bluuebunny/crossref_metadata_2025 huggingface dataset:
A survey of the current situation in Japan with regard to the recruitment of care workers and a study of measures to secure care workers
Authors: Mitsu Hitomi , Amitani Marie , Ibusuki Rie , Mizuma Kimiko , Owaki Tetsuhiro
Published: August 2022

BackgroundJapan has one of the world's lowest birthrates and an ageing population. As the number of elderly people increases, the number of care workers required in all prefectures across Japan is expected to rise until 2040. There are serious shortages, particularly in urban areas. This study investigated and analyzed the policies of prefectures across Japan towards securing nursing care staff, and it sought to clarify the issues related to nursing care in a society with low birthrates and an aging population.MethodsSurvey period: September-October 2020. The Ministry of Health, Labour and Welfare (MHLW), which oversees all aspects of healthcare in Japan, conducted a web-based search to determine the items deemed necessary, referring to its "Measures to Secure Human Resources for Welfare and Nursing Care". The websites of 47 prefectures were accessed, and each of these items was searched on the Internet using the phrase "securing nursing care workers" to see if any of the survey items were among the top 20 search results.ResultsThe percentage of prefectures that use the "nursing care facility certification evaluation system" in the field of the working environment was the lowest. The prefectures that have adopted the nursing care facility certification evaluation system are concentrated in the Kanto and Chubu regions, where the population is concentrated. The number of establishments undergoing "third-party evaluation of welfare services" was high in Tokyo, Kanagawa, and Aichi, which are major cities in Japan.ConclusionThe shortage of nursing care workers is particularly acute in urban areas, making it difficult to secure staff. There is a need for a multi-pronged approach, including better pay for care workers, improved working conditions, and technological innovation.
AVE 0991 suppresses neuroinflammation of Alzheimer's disease by enhancing autophagy in astrocytes
Authors: Deng Yang , Wang Siyu , Wang Qingguang , Xu Zhaohan , Peng Qiang , Chen Shuaiyu , Zhu Lin , Zhang Yingdong , Duan Rui
Published: August 2022

In our previous study, we have shown that AVE 0991, a nonpeptide analogue of Ang-(1–7), ameliorates cognitive decline and inhibits NLRP3 inflammasome of astrocytes in Alzheimer's disease model mice. Additionally, several studies have suggested that activation of autophagy appears to effectively inhibit the progression of neuroinflammation. However, it is unclear whether AVE 0991 can modulate astrocyte autophagy to suppress neuroinflammation in Alzheimer's disease. In our study, we showed that 30 days of intraperitoneal administration of AVE 0991 improved cognitive deficits and neuronal death in APP/PS1 Alzheimer's disease model mice. Moreover, AVE 0991 treatment greatly suppressed astrocyte-mediated inflammation and up-regulated the expression of autophagy. Furthermore, the inhibitory effect of AVE 0991 on the expression of inflammatory factors was reversed by 3-MA, an autophagy inhibitor. These findings suggest that regulation of autophagy is critical for inhibiting astrocyte neuroinflammatory responses and demonstrate a potential neuroprotective mechanism by which AVE 0991 could suppress neuroinflammatory responses by enhancing autophagy.
Evaluation of water quality index, Levels and Human Health Risk of Metals in Packaged Groundwater from Abeokuta and Sagamu, Ogun State Nigeria
Authors: Taiwo Adewale M. , Ogunsola Deborah O. , Babawale Mutiat K. , Isichei Onyinyechukwu T. , Olayinka Sukurat O. , Adeoye Ifeoluwa A. , Adekoya Ganiyat A. , Tayo Olamide E.
Published: August 2022

Groundwater is an important drinking water source in many developing countries of the world. Contamination of this important resource could lead to serious and irreparable health implications for the consumers. This study, therefore, assessed the water quality index (WQI), levels and human health risk of metals in packaged/sachet groundwater collected from Abeokuta and Sagamu, Ogun state Nigeria. One hundred and forty bags of packaged groundwater from different sampling sites were analysed for metals using inductively coupled plasma - optical emission spectrophotometry (ICP-OES). Packaged groundwater data were analysed for simple descriptive and inferential statistics. Human health risk assessment of metals through consumption of packaged groundwater was evaluated for hazard index (HI), hazard quotient (HQ), and cancer risk (CR). Most of the packaged groundwater parameters were within the permissible limits of the World Health Organization except Mn (1118 ± 1719–1727 ± 2218 µg/L) and Fe (491.8 ± 559.1 µg/L) in selected samples. The WQI data (< 100) indicated suitability for drinking purposes, but when regressed against the health risk indicators showed a weak non-significant positive association. The health risk evaluation of metals revealed high HQs > 1.0 for Ca, Mn, Mo, and Cu through consumption packaged groundwater by adults and children at some sampling sites. The CRs for Co and Ni at most monitoring sites indicated values greater than the acceptable limit of 1 x 10− 4, indicating possible cancer development by the consumers.
LncRNA scaRNA2 bridges DNA end-resection to homologous recombination repair mediated chemoradioresistance
Authors: Yang Yanyong , Chen Yuanyuan , Shen Hui , liu tingting , Cao Kun , Wan Zhijie , Du Zhipeng , Wang Hang , Yu Yue , Ma Shengzhe , Li Bailong , Zhang Wei , Cai Jianming , Gao Fu
Published: August 2022

As a potent target for cancer therapy, ATR mainly regulates homologous recombination (HR)-mediated DNA damage repair. Our previous study first identified that ATR binding long noncoding RNA (lncRNA) is necessary for ATR function and promotes cancer resistance. However, most important lncRNAs, as critical factors for ATR activation, are largely unknown. In the present study, scaRNA2, the most enriched ATR-binding lncRNA, was identified and well characterized. ScaRNA2 was found to be essential for HR-mediated DNA damage repair. Furthermore, scaRNA2 knockdown abrogated the mobilization of ATR and its substrates in response to DNA damage. Mechanistically, scaRNA2 was observed to be necessary for Exo1-mediated DNA end resection and bridged the MRN complex to ATR activation. Using cancer cells and a cell-derived xenograft model, we demonstrated that lentivirus-based knockdown of scaRNA2 effectively increases sensitivity to multiple kinds of chemoradiotherapy. Preclinically, knockdown of scaRNA2 improved the therapeutic effects of radiotherapy on patient-derived organoids and xenograft models. Finally, upregulation of scaRNA2 colocalized with ATR was also found in clinical patients who are resistant to radiotherapy based on tumor regression grades. In conclusion, we identified scaRNA2 as the most abundant lncRNA bound to ATR and uncovered its mechanism in bridging DNA end resection to ATR activation, which could be applied as a potent target for combined cancer treatments with chemoradiotherapy.
Predictive model for persistent hypertension after surgical intervention of primary aldosteronism
Authors: Li Zhuoying , He Yunfeng , Zhang Yao , Chen Gang , Zheng Yongbo , Guo Yuan , Quan Zhen , Wu Xiaohou
Published: August 2022

Background: Primary aldosteronism (PA) is one of the most common causes of secondary hypertension and is potentially curable. However, a large number of patients still undergo persistent hypertension (PHT) after unilateral adrenal surgery. This research retrospectively studied the factors associated with this clinical difficulty and established a prediction model for the postoperative PHT; Methods: 353 patients from 2014 to 2021 with PA undergoing unilateral adrenal surgery were enrolled in this study. Clinical and biochemical characteristics were reviewed and the associating factors were examined using univariate and multivariate analysis. A nomogram-based prediction model was established correspondingly; results: 46.2% (163/190) of patients had post-surgical PHT. Multivariate analysis suggested that BMI≥25, diabetes, duration of hypertension, male gender, and ARR were independent predictors of PHT after surgery. The prediction model based on the nomogram showed good discrimination ability (the C index of the training group and the validation group were 0.783 and 0.769, respectively), and the calibration curves were good as well. Clinical usefulness was quantified using the decision curve analysis (DCA); Conclusion: This nomogram is an integration of the clinical and biochemical data of patients before surgery, and is a reliable tool with high accuracy for predicting the postoperative PHT in patients with PA.
Repeatability assessment of anterior segment biometric measurements in myopic patients using a new anterior segment OCT with Placido corneal topography and agreement with a swept-source OCT
Authors: Wang Hao , Zhu Li-Shuang , Pang Chen-Jiu , Fan Qi
Published: August 2022

The precision of anterior segment biometric measurements in eyes has become increasingly important in refractive surgery. The purpose of this study is to assess the repeatability of the automatic measurements provided by a new spectral-domain optical coherence tomograph (SD-OCT)/Placido topographer (MS-39, CSO) and its agreement with a swept-source OCT (SS-OCT) biometer (CASIA SS-1000, Tomey) in patients with myopia. The right eye of 235 subjects was scanned 3 times with both devices. The evaluated parameters included central corneal radius of the steep meridian, central corneal radius of the flat meridian, mean central corneal radius, thinnest corneal thickness, central corneal thickness, anterior chamber depth, corneal volume and diameter. The repeatability of the MS-39 measurements was calculated using intraclass correlation coefficient (ICC), within subject standard deviation, coefficient of repeatability, coefficient of variation and repeated-measures analysis of variance. The agreement between the two devices was evaluated by 95% limits of agreement. The majority of the parameters showed high repeatability. The repeatability of corneal diameter was slightly lower than the other measurements, although the ICC remained high. Agreement with the SS-OCT was good for all parameters assessed. The high repeatability of automatic measurements by the new device supports its clinical application in myopic eyes with myopia, and the good agreement between the two devices indicates they could be used interchangeably for the parameters evaluated.
Evidence of triplinerved cinnamon from the Siwalik (middle Miocene) sediments of Darjeeling foothill and its biogeographic implication: Asian perspective
Authors: Mahato Sumana , Hazra Taposhi , Khan Mahasin Ali
Published: August 2022

Cinnamomum Schaeffer (avocado family Lauraceae), commonly known as a cinnamon tree, is a highly diverse, economically important evergreen element of tropical and sub-tropical regions of the world. In the present work, we have recovered six compressed leaf remains similar to modern leaves of Cinnamomum from the lower part of the Siwalik strata (middle Miocene) of Darjeeling foothills, eastern Himalaya. The recovered fossil specimens are characterized by an elliptic to the ovate lamina, acute to short acuminate apex, round to acute base, and basal as well as suprabasal acrodromous type of primary venation. Based on preserved architectural features, Siwalik fossil leaves are confidently placed under the genus Cinnamomum. However, the recovered Siwalik specimens cannot be traced up to the species level due to a lack of satisfactory macromorphological features (especially tertiary veins) and epidermal anatomy and are designated here as morphotypes. The evidence of current Siwalik specimens and earlier-reported fossil species similar to thermophilic Cinnamomum in appreciable number from other Siwalik localities (Darjeeling, Uttarakhand, and Nepal) suggests that Cinnamomum was a common Siwalik element and the existence of tropical, warm and humid climatic conditions during the Siwalik sedimentation. This finding also represents an important source of data for understanding the evolution, diversification, and paleobiogeographic history of Cinnamomum from an Asian perspective in deep time.
Efficacy and Safety of the Juan Bi Pill Combined with Methotrexate for Treating Active Rheumatoid Arthritis
Authors: Jia Qingyun , Wang Yiru , Sun Dawei , Li Qiang , Mao Jianchun , Xue Luan , Gu Xiaohua , Yu Xiang , Piao Xuemei , Lu Sheng , Shi Qi , Wang Yongjun , Xu Hao , Liang Qianqian
Published: August 2022

Objective:Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by swelling and pain in the joints, which eventually lead to joint destruction. The Juan Bi pill is a Chinese medicine that has been widely used to treat RA in China for hundreds of years. This study demonstrated the effect of the Juan Bi pill on the management of active RA.Methods:Participants received a dose (4 g, twice a day p.o.) of the Juan Bi pill or placebo (tid p.o.) for 12 weeks. Participants were required to take the Juan Bi pill for 3 months with follow-up visits at 6 and 12 months, attending seven assessment visits. Participants will undergo disease activity and safety assessments seven times (at baseline and at 1, 2, 3, 6, and 12 months). The primary endpoint was the 28-joint Disease Activity Score (DAS28-ESR and DAS28-CRP). The secondary endpoints included blood sampling for erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), Health Assessment Questionnaire Disability Index, clinical disease activity index (CDAI), visual analog scale, Short Form-36 score, and morning stiffness.Results:Altogether, 213 participants were screened, and 115 participants were randomized into two groups (Juan Bi pill group, n = 57; placebo group, n = 58); four dropped out. After 12 weeks of treatment, the DAS28-ESR and DAS28-CRP scores of the two groups were significantly reduced. The Juan Bi pill group had significantly reduced DAS28-ESR and DAS28-CRP scores and a significantly higher standard rate of the European League Against Rheumatism score than the placebo group (P < 0.05). After treatment, the number of tenderness/swelling joints, CDAI score, and serum ESR and CRP levels in the two groups demonstrated a decreasing trend, which were all reduced compared with those before treatment. In the electrocardiogram, routine blood tests, liver and kidney functions, and other indices before and after treatment, the adverse reaction rate of the two groups did not increase.Conclusions:TheJuan Bi pill combined with methotrexate can effectively reduce disease activity in participants with RA in the active stage, reduce the symptoms of arthritis, and improve the quality of life, while ensuring safety, reliability, and fewer adverse effects.Trial registration: ClinicalTrials.gov, NCT02885597. Registered on 30 August 2016.
Extraction of Partial Discharge Signal in Predominantly VHF Frequency Range in the Presence of Strong Noise in Power Transformer
Authors: Dukanac Djordje
Published: August 2022

This paper provides a detailed analysis of the online detected partial discharge (PD) in the predominantly VHF range in the power transformer during normal operation in the thermal power plant. A standard UHF drain valve sensor is used with the ability to also capture VHF frequencies of received signals. If PD detection is performed during off-line testing, there are excessive costs proportional to the time during which the power transformers are disconnected from the network. For this economic reason, online PD detection techniques are more convenient. The UHF technique has a higher signal-to-noise ratio compared to IEC 60270 and the acoustic method. To accurately determine the strength and waveform of the PD signal, especially if the source position is far from the UHF sensor or if the signal is weak, it is necessary to properly separate the useful part of the recorded signal from the background noise. The criterion for this is that there are no time shifts of the first peaks of the most prominent PD. For that reason, the beginning and the approximate end of PD signal has to be determined. The results show some obvious similarities of PDs in the recorded signals, such as frequency range, duration, repetition rate and the same dominant frequency, which sufficiently indicates that it is the same type of PD.
Open surgery with a lateral neck approach in cases of foreign body impaction that penetrating the neck through the oesophagus: single- center experience
Authors: Xu Feng , Shen Na , Danzheng Liu
Published: August 2022

Background
Because the cases of foreign body impaction penetrating the neck through the oesophagus are quite scare and doctors have not enough therapeutic experience, we aimed to review cases of foreign body impaction penetrating the neck through the oesophagus to analyze the characteristics of these cases. The open surgery skills of the surgeon, the treatment procedure and the surgeons’ experience in the rare diseases were analyzed.
Methods
We collected and analyzed all cases from 2015–2020 in our hospital treated with open surgery through a lateral neck approach for foreign body impaction in the neck penetrating through the cervical esophagus. The surgical area included the neck, super-mediastinum, left subclavian artery. The clinical characteristic of the cases, surgical skill and procedures for fasting and anti-infection treatment after surgery was studied retrospectively. Following up was with telephone communication.
Results
Our series included fifteen cases of neck and mediastinum abscesses, mediastinitis and artery aneurysmal haematoma due to cervical oesophagus foreign bodies. Tenderness in the pre-cervical site was a physical sign for screening, especially the site above the upper suprasternal fossa. All patients underwent neck, superior-mediastinum, or vessel surgeries. Thirteen cases underwent a lateral neck open surgery with the incision including the left side of neck and only two cases were incised from the right side of the neck. Pus was found 3 days after the impaction in one case, the shortest time observed in our series. the oesophageal laceration was only sutured primarily in 5 cases (33.33%) in all fifteen casas. After sufficient drainage (more than 9 days), antibiotic treatment and fasting (normally 2–3 weeks), the patients gradually began changing to solid foods from fluids after complete blood count and oesophageal radiography result confirmations. Through the following up with telephone, we learned that no severe complications occurred, and all the patients have no swallowing dis-function and recovered well.
Conclusion
Cervical oesophagus perforation due to impaction of a foreign body might be liable to occur in the left side of the patient’s neck. Pus and abscess cavity will begin to form after the impaction history of 3 days, so the surgery should be performed as soon as possible after foreign body impaction and penetrating the neck through oesophagus. It had better in 3 days after impaction. The lateral neck approach surgery and the therapeutic procedure introduced in this article are safe and effective treatments for cases of mis-swallowed foreign bodies penetrating the neck through esophagus.
Structure and properties of active biodegradable films based on starch acetate, low-molecular chitosan and polyvinyl alcohol mixtures
Authors: Kochkina Nataliya E. , Butikova Olga A.
Published: August 2022

The aim of this work was to propose new inexpensive compositions based on a mixture of starch acetate (AcSt), low molecular weight chitosan (LwCh), and polyvinyl alcohol (PVA) for preparation of active biodegradable films for various applications. To this end, the influence of biopolymer concentrations in the mixtures on the formed film structures was studied by the X-ray and SEM methods. The water-related, mechanical and UV-protective properties of the films were also evaluated. It was shown that among the studied samples, the films including 18-20 wt% PVA and 20-25 wt% LwCh had the most homogeneous structure and the best tensile strength and elongation at break. An increase in the LwCh concentration to 30 wt% resulted in films with solubility values close to those of edible systems. All the films were found to possess UV-protective properties. A seed germination test showed that the AcSt/LwCh/PVA systems promoted plant growth. Depending on the ratio of polymer components, such films can be recommended for use as food packaging, mulch coatings or pharmaceutical film materials.
TRPA1 deficiency attenuates cardiac fibrosis via regulating GRK5/NFAT signaling in diabetic rats
Authors: Zhao Mengmeng , Zheng Zihui , Xu Yao , Zhang Jishou , Pan Wei , Yin Zheng , Liu Jianfang , Xu Shuwan , Wei Cheng , Wan Jun , Wang Menglong
Published: August 2022

Diabetic cardiac fibrosis increases ventricular stiffness and promotes diastolic dysfunction. The transient receptor potential ankyrin 1 (TRPA1) has been reported to be associated with the occurrence and development of various cardiovascular diseases. However, the role of sperm TRPA1 in diabetic cardiomyopathy (DCM) remains unclear. Here, we investigated the cardioprotective effects of TRPA1 deficiency on DCM in streptozotocin (STZ)-induced diabetic rats and in neonatal rat cardiac fibroblasts (CFs) incubated with high glucose (HG). The results showed that the expression of TRPA1 was increased in the cardiac tissue of diabetic rats and in CFs treated with HG. TRPA1 deficiency significantly ameliorated cardiac dysfunction in diabetic rats, characterized by improved echocardiography and reduced cardiac hypertrophy and fibrosis. In vitro, TRPA1 deficiency suppressed HG-induced activation and transdifferentiation of CFs. Mechanistically, the cardioprotective effect of TRPA1 deficiency inhibited cardiac fibrosis by regulating GRK5/NFAT signaling. Furthermore, inhibition of GRK5/NFAT signaling abolished TRPA1 activation-induced transdifferentiation of CFs. For further clinical translation, we utilized 1,8-cineole (CIN), a natural inhibitor of TRPA1, to treat DCM. Inhibition of TRPA1 activation by CIN attenuated cardiac dysfunction and remodeling in diabetic rats by regulating GRK5/NFAT signaling. Taken together, these results suggest that TRPA1 deletion protects against DCM in vivo and in vitro by regulating GRK5/NFAT signaling. TRPA1 inhibitor CIN may serve as novel therapeutic agents for the treatment of DCM.
A novel MDM2-p53 antagonist APG115 exerts synergistic effect with ibrutinib via targeting MCL-1 in chronic lymphocytic leukemia
Authors: Han Yang , Hu Xinting , Wang Hua , Tian Zheng , Zhang Xin , Hu Shunfeng , Zhang Ya , Wang Xin
Published: August 2022

APG115 is a highly selective small-molecule inhibitor of MDM2-p53 interaction with oral activity, which restores p53 activation in patients with solid tumors in clinical trials. The Bruton tyrosine kinase inhibitor (BTKi) ibrutinib exhibits significant efficacy in chronic lymphocytic leukemia (CLL) patients including high-risk patients. However, the chemoresistance of ibrutinib still needs to be addressed urgently. Herein, we first demonstrated that the APG115 exerted apoptogenic and antiproliferative effects, and induced G0/G1 cell cycle arrest in CLL. As an agent used either alone or in combination with ibrutinib together, APG115 provided remarkable antitumor activity and overall survival extension in vivo. Mechanistically, the activation of p53 positively regulates the p53/p21 pathway, prompting MCL-1 degradation via inducing its ubiquitination. On basis of the upregulation of MCL-1 in CLL cells with ibrutinib resistance, these evidences explain how APG115 reduces the resistance of ibrutinib in CLL. This study offers promising prospects to constitute effective regimens of APG115 combined with ibrutinib for the CLL treatment.
Investigating the intensity of the X-ray beam reflected from a single crystal of ammonium dihydrogen phosphate (ADP) due to X-ray transfer from the transmission to reflection direction under a temperature gradient
Authors: DEZFOULI MEHDI GHANAD , TROUNI KARAPET
Published: August 2022

This paper investigates the phenomenon of X-ray radiation transfer from the direction of transmission to the reflection direction in Laue geometry from the atomic planes of a single crystal of ammonium dihydrogen phosphate (ADP) under the influence of a temperature gradient. The experiment results demonstrated that as the temperature gradient increases, the reflection intensity increases uniformly by more than 11 times. This phenomenon has been described using an asymptotic solution based on the dynamical X-ray diffraction in crystals with weak deformation. At low-temperature gradients, theoretical and experimental results were in good agreement.
The protective properties of resveratrol on lactate dehydrogenase activity in toluene exposed rats
Authors: Dere Egemen , Tuna Gonca , Arfaoui Aboush El
Published: August 2022

Toluene is an aromatic hydrocarbon found in nature mainly in crude oil. Since it is a good solvent and has less toxic effects, it is preferred to be used instead of benzene in the industry. Toluene causes damage to the lungs and nervous system by contaminating chronically or acutely, especially through the respiratory tract. Resveratrol (RES) which is found in many fruits, especially grapes, provides antioxidant support to the body and shows protective properties against harmful substances. The aim of this study is to examine the negative effects of toluene on lactate dehydrogenase (LDH) activity in blood, liver and muscle tissue and to investigate the protective effects of RES against toluene. In the study, rats were divided into two groups as control and experimental groups. The first experimental group was injected with toluene at a dose of 900mg/kg intraperitoneally for 6 days. While the 2nd experimental group was given the same dose of toluene and 5mg/kg RES, the 3rd experimental group was given the same dose of toluene with 10mg/kg RES, the 4th experimental group was given the same dose of toluene and 20mg/kg RES. In the study two control groups, serum physiological and ethanol control groups, were used. After 6 days, all rats were killed by cervical dislocation. Blood, liver and muscle tissues were rapidly extracted from rats. LDH activities were determined. As a result, it was seen that toluene increased LDH activity and RES played a regulatory role in LDH activity.
Policy Linkage of Governments in Air Pollution Control: An Empirical Analysis Based on China's Policy Texts
Authors: Zhang Peide , Lin Zhongguo , Peng Binbin , Du Huibin
Published: August 2022

Understanding the multisectoral and multiregional cooperation which coordinates the relationship between different government actors and integrates their policies is essential to effectively address increasing regional air pollution. Although the literature on effects of polices is rapidly expanding, little is known about the actual extent of policy linkage of multisector and multiregion, resulting in policy conflicts and duplications. Using 13486 policy documents in China from 2000 to 2018, we combine machine learning methods with social network analysis to investigate the policy content and linkage in central departments and local departments. We find that, firstly, the coordination of central departments is constantly improving, mainly focusing on the Comprehensive Control and the Publicity Guide, with little attention to market-oriented measures. Secondly, since local governments have similar policy foundations in Emergency Management, Total Amount Control, Dust Control, and Moving Pollution Control, they are able to cooperate in these aspects, even when there are differences in local regulations. This paper provides suggestions for the further coordination of the central government, as well as the direction of policy integration for local governments.
Differential response of growth and C:N:P stoichiometry to Si supply between bamboo and other tree seedlings
Authors: Liu Xiaoyu , Tang Xinghao , Compson Zacchaeus G. , Huang Dongmei , Zou Guiwu , Luan Fenggang , Song Qingni , Fang Xiong , Yang Qingpei , Liu Jun
Published: August 2022

AimsSilicon (Si), while not an essential element for plant growth, can be important for high Si-accumulating Poaceae, such as Moso bamboo. However, other trees do not actively take up dissolved silicic acid [Si(OH)4] from the soil, likely because they have fewer or no specific Si transporters in their roots. It is unclear what causes the different growth and nutrient status between bamboo and other trees under varying Si supply. To explore the influences of Si availability on the growth, photosynthesis, nutrient status and C:N:P stoichiometry of bamboo and other trees.MethodsWe used one-year seedlings of P. pubescens, P. bournei, S. superba and C. lanceolata in a pot experiment where three widely differing levels of silicon were supplied, and measured growth traits, photosynthetic gas exchange properties and C:N:P stoichiometry of seedling responses to three levels Si supply and analyzed the impacts of Si supply on growth and nutrient status of bamboo and tree saplings.ResultsWe found that Si increased the biomass production of P. pubescens seedlings with the higher concentration of Si supply, likely by improving its photosynthesis and nutrient status net photosynthetic rate, which contrasted to the seedlings of P. bournei and S. superba. In addition, we found that C concentrations of aboveground tissues in P. pubescens declined with increasing Si supply, likely due to a partial substitution of organic C compounds by Si. We also found that Si treatments increased the foliar C:N stoichiometry in the seedlings of P. bournei and S. superba through altering their concentration of C and N, but did not affect the C:N or N:P stoichiometry of C. lanceolata and P. pubescens.ConclusionsSi elicited either a positive or negative effect on plants, such as improve or weaken photosynthetic capacity, increase or decrease the concentration of C and N in plants, depending much on plant species and the ambient supply level of Si in the environment. These results have implications for assessing the growth and nutrient status between bamboo and other trees (i.e, high Si-accumulating plants compared to other plants) when Si availability is altered in ecosystems, such as when Si availability in ecosystems is altered by bamboo expansion.
Systematic Mapping of Monolithic Applications to Microservices Architecture
Authors: Seedat Momil , Abbas Qaisar , Ahmad Nadeem
Published: August 2022

In recent years, microservices architecture has emerged as a new architectural style in the software development industry. As legacy monolithic software becomes too large to manage, many large corporations are considering converting their traditional monolithic systems into small-scale, self-contained microservices. However, migrating from monolithic to microservices architecture is a difficult and challenging task. Finding clear instructions on refactoring monolithic applications can be difficult for software architects. In this paper, we compared the two architectural styles and talked about the difficulties that led to the companies' decision to switch over microservices architectures. Furthermore, a case study of a financial application is presented, in which we discussed our technique for identifying microservices on monolithic systems using domain driven concepts, as well as various communication protocols for service interaction. The study's findings showed that this proposed technique helped to establish clear models and enhanced work performance, but it may not be useful for systems with lower levels of complexity.
Warren Shunt- Positive Outcomes for Cavernous Portal Vein Transformation in a Young Patient
Authors: Adrian Boicean , Ciprian Tanasescu , Sabrina Birsan , Horatiu Dura , Cosmin Mohor , Calin Mohor , Dan Bratu , Radu Fleaca
Published: August 2022

In this paper we want to highlight the importance importance of Warren Shunt- (anastomosis of the splenic vein and the left renal vein) was performed in order to lower the PHT, and prevent the risk of gastrointestinal bleeding. Children with CTPV often manifest with gastroesphageal variceal bleeding which can be a life-threatening condition for young patients. Studies show that CTPV in cases of children may occur because of inherited or acquired prothrombotic disorders, abdominal infections. Our research team presents the case of a 22 years old, male patient, N. S. who had cavernous transformation of the portal vein at 2 years old and our case presentation presents the benefits of a surgical Warren Shunt- (anastomosis of the splenic vein and the left renal vein) in order to lower the PHT, and prevent the risk of gastrointestinal bleeding. In the case we present this type of surgical intervention was life saving and improved the quality of life of our patient.
Fourteen Traitors’ Portraits: on the Role of Visual Images in the English Cheap Print of the Late 16th Century
Authors: Карначук Н.В.
Published: August 2022

В статье рассматривается комплекс бродсайдов, посвященных разоблачению заговора Энтони Бабингтона в 1586 г. Анализируется их авторство, текстовое и визуальное содержание, делается вывод о том, что они появились как пропагандистская попытка власти сформировать благоприятное общественное мнение. Особое внимание уделяется визуальным образам и особенностям их распространения, копирования и восприятия в массовом сознании англичан конца XVI века.

The article deals with a set of broadsides dedicated to exposing the conspiracy of Anthony Babington in 1586. Their authorship, textual and visual content is analyzed and it is concluded that they appeared as a propaganda attempt by the authorities to form a favorable public opinion. Particular attention is paid to visual images and the peculiarities of their distribution, copying and perception in the mass consciousness in late 16th century England.
“The Book of Tasty and Healthy Food” in the System of Ideological Myths Characteristic of the Transition from the Khrushchev Thaw to the Brezhnevian Stagnation
Authors: Попова О.Д.
Published: August 2022

В статье анализируется место «Книги о вкусной и здоровой пище» 1960-х гг. в системе идеологической пропаганды. Автором показано, что текст книги отражал трансформации, которые происходили в повседневной жизни советских граждан под влиянием крушения «большого сталинского стиля». На основе выявленных обращений граждан в органы власти и к лидерам государства автор показывает трудности советского быта середины 1960-х: дефицит продуктов, проблемы получения качественного жилья и др. В итоге автор приходит к выводу о двойственности декларируемых в «Книге о вкусной и здоровой пище» принципов социалистического быта и реальных бытовых практик. Данное издание выполняло уже другую функцию, чем прежние: оно пыталось сгладить недостатки социалистического строя. Однако книга все больше превращалась в миф о благополучии советской системы, рассказывая о товарах, которые нельзя было найти на прилавках.

The article analyzes a fourth edition of the Book of Healthy and Tasty Food, which was published in the 1960s, against the backdrop of ideological propaganda characteristic of the period. The author maintains that the text of this edition reflected various transformations of Soviet citizens’ everyday life initiated by the Khrushchev thaw. The author analyzes Soviet citizens’ letters and appeals to government bodies and political leaders to highlight the difficulties experienced by Soviet citizens’ in their everyday life in the mid-1960s: food deficit, housing shortage, problems associated with female labour. The author concludes that there was a huge gap between the communist way of life advertised in the Book of Healthy and Tasty Food and the reality. The author underlines that the edition issued in the 1960s was hoped to mitigate the aforementioned problems. But it turned out to serve an image of what the Soviet state aspired to be, it became a myth of abundance which was hopelessly unattainable for a common Soviet person.
Political Authorities in Ancient India: Religious and Ideological Consideration and Forms of Implementation
Authors: Емельянова Н.Н.
Published: August 2022

Статья посвящена социокультурным факторам обоснования и реализации политической власти в Древней Индии. Рассмотрены политические аспекты брахманизма: идея о политическом доминировании брахманов над кшатриями, идея о божественной природе царской власти, идея о насильственной природе власти. Отмечен новаторский характер этих идей для периода их возникновения и развития. Отдельное внимание уделено проблеме соотношения дхармы (следования долгу) и артхи (следования практической пользе) в гармоничном обществе. Рассмотрено решение этой проблемы политической мыслью Древней Индии, в том числе в политическом трактате «Артхашастра». Кроме того, в статье раскрыты монархические и республиканские традиции древнеиндийской государственности. Отмечается некорректность сведения традиции ранней индийской государственности исключительно к одной из модификаций восточного деспотизма.

The article is devoted to the socio-cultural factors of justification and implementation of political authority in Ancient India. The political aspects of Brahmanism are considered: the idea of the political dominance of Brahmins over Kshatriyas, the idea of the divine nature of royal authority, the idea of the violent nature of authority. The innovative nature of these ideas for the period of their origin and development is noted. Special attention is paid to the issue of the correlation of dharma (following duty) and artha (following practical benefits) in a harmonious society. The solution of this problem is considered by the political thought of Ancient India, including in the political treatise "Arthashastra". In addition, the article reveals the monarchical and republican traditions of Ancient Indian statehood. It is noted that it is not correct to reduce the tradition of early Indian statehood exclusively to one of the modifications of Eastern despotism.
Propaganda and Formation of Ideas about Civil Identity in the FBI (1930–1940’s)
Authors: Левин Я.А.
Published: August 2022

Период 1930-х – 40-х гг. стал временем бурного развития такой структуры как Федеральное Бюро расследований. Пройдя через комплекс реформ Джона Эдгара Гувера, ведомство и его кадровый состав претерпели серьёзные изменения. Одним из важнейших вопросов, поднимаемых директором в ходе его преобразований, стал морально-нравственный облик агентов, правила поведения и идея гражданской идентичности в рядах ФБР. Выработанные в то время идеалы и модели поведения станут основной пропаганды этого ведомства на долгие годы.

The period of the 1930s - 40s became a time of rapid development of such a structure as the Federal Bureau of Investigation. Having gone through the reform complex of John Edgar Hoover, the department and its personnel have undergone serious changes. One of the most important issues raised by the director during his transformations was the moral appearance of agents, the rules of conduct and the idea of ​ ​ civic identity in the ranks of the FBI. The ideals and behaviors developed at that time will become the main propaganda of this department for many years.
Interview with Professor Malyn Newitt
Authors: Соколов А.Б.
Published: August 2022

В интервью М. Ньюитт рассказал об обучении в Винчестере и в Оксфордском университете, о становлении своей профессиональной карьеры. Он делится воспоминаниями о преподавании в Родезии, рассказывает о формировании его исследовательских интересов в области истории Африки. В интервью затрагиваются не только направления научной работы историка, не только его общественная деятельность, но и черты развития профессии историка в целом, более, чем за полвека. М. Ньюитт изложил свои взгляды на основные тенденции в эволюции британской историографии, подчеркнул ее методологические особенности. Он обратил внимание на вклад отдельных ученых и достижения современной историографии.

In the interview the period of study of the future historian in Winchester and Oxford is considered, as well as formation of his professional carrier. Newitt shares his memoires about teaching in Rhodesia, tells us about the formation of his research interests in the field of history of Africa. In the interview not only his research and public activities are considered but the development of the profession of historian, in general, for longer than half a century. Professor Newitt explains his views on the main tendencies in evolution of British historiography, and stresses on its’ methodological particularities. He attracts attention to the contributions of some historians and the achievements of contemporary historiography.
Portrait in the manner of sfumato: Metaphor and intellectual biography
Authors: Селунская Н.А.
Published: August 2022

Автор анализирует вышедшую в свет в 2021 г. книгу Т.Н. Поповой – исследование биографии оригинального мыслителя, историка, филолога, литературного критика П.М. Бицилли, а также те специфические историко-теоретические проблемы создания интеллектуальной биографии и изучения истории в персональном измерении, которые интерпретируются в монографии.

The author analyzes the recent monograph of T.N Popova, published in 2021 and devoted to biography of P. Bicilii, original thinker, historian. The book of Popova also deals with the problems of historiography, intellectual history, Russian emigration culture, personal history and intellectual biography.
Mythology of Time and Rhythms of Eternity: the Transformation of the Historical Culture of the Youth Movement in Germany (1900-1933)
Authors: Линченко А.А.
Published: August 2022

Статья представляет собой рецензию на монографию Р.-Я. Адриаансена “The Rhythm of Eternity. The German Youth Movement and the Experience of the Past, 1900-1933”, где представлен анализ трансформации исторической культуры молодежного движения в Германии 1900–1933 гг., как в аспекте теоретических представлений о времени и истории, так и в аспекте коммеморативных практик молодежи. На основе идей Гумбрехта автор показывает, что активно формировавшаяся в начале ХХ в. историческая культура молодежного движения в Германии может быть рассмотрена как случай культуры присутствия, ориентированной на экзистенциальный опыт, космологические ритмы и пространственное восприятие событий прошлого. Вместе с тем эволюция оригинальной мифологии времени, выработанной в молодежной исторической культуре, была актуализирована политической и социально-экономической ситуацией, а молодежные движения, являясь частью «консервативной революции», стремились не столько противостоять модернистскому историческому сознанию, сколько трансформировать вектор его дальнейшего развития. На примере молодежного движения автор показывает, что историческая культура Веймарской Германии была своего рода «лабораторией экспериментов» с различными видами темпоральностей.

The article is a review of the monograph by R.-J. Adriaansen (R.-J. Adriaansen. The Rhythm of Eternity. The German Youth Movement and the Experience of the Past, 1900-1933. London / New York: Berghahn Books, 2015.227 p.). The monograph analyzes the features of the transformation of the historical culture of the youth movement in Germany in the period 1900-1933, both in the aspect of theoretical ideas about time and history, and in the aspect of commemorative practices of youth. Based on the ideas of H.U. Gumbrecht's, author shows that the historical culture of the youth movement in Germany, which was actively formed at the beginning of the last century, can be considered as a case of a presence culture focused on existential experience, cosmological rhythms and spatial perception of past events. At the same time, the book shows that the evolution of the original mythology of time, developed in the youth historical culture, was updated by the current political and socio-economic situation. The book substantiates the idea that the German youth movements of 1900-1933, being part of the “conservative revolution” of German society, did not so much strive to oppose the modernist historical consciousness as to transform the vector of its further development. Using the example of the German youth movement, the author shows that the historical culture of Weimar Germany was a kind of laboratory for experimenting with various types of temporalities.
Respon Tanaman Alfalfa (Medicago sativa L.) terhadap Pemberian Pupuk Organik Cair dengan Sistem Hidroponik Rakit Apung
Authors: Ridwan Muhamad , Laili Saimul , Tito Sama’ Iradat
Published: August 2022

Kesadaran masyarakat akan pentingnya kesehatan dan pemenuhun gizi menyebabkan permintaan akan sayur-mayur semakin meningkat. Tanaman alfalfa sebagai salah satu tanaman sayur dengan kandungan nutrisi yang lengkap, akan tetapi tanaman ini belum banyak dikenal oleh masyarakat Indonesia . Penelitian ini bertujuan untuk mempelajari respon pertumbuhan tanaman alfalfa (Medicago sativa L.) terhadap pemberian pupuk organik cair (POC) NASA dan NUPOC dengan sistem hidroponik rakit apung menggunakan cahaya lampu LED cool daylight. Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) yang terdiri atas 2 faktor. Faktor pertama yaitu jenis pupuk organik cair (X) dan faktor kedua yaitu konsentrasi pupuk organik cair (Y). Setiap perlakuan diulang sebanyak 5 kali sehingga terdapat 45 satuan percobaan dan setiap satuan percobaan terdapat 2 tanaman, sehingga jumlah keseluruhan tanaman yaitu 90 tanaman. Hasil penelitian menunjukkan pemberian POC NASA mendukung pertambahan panjang, luas daun, dan panjang akar tanaman yang lebih baik dibandingkan NUPOC. Sebaliknya, pemberian NUPOC memberikan respon pertumbuhan jumlah daun, jumlah akar, bobot kering dan bobot basah tanaman yang lebih baik dibandingkan POC NASA. Konsentrasi pekat dari setiap POC NASA dan NUPOC pada konsentrasi 6% dan 8% memberikan respon pertumbuhan tanaman alfalfa yang lebih baik untuk semua parameter pengamatan.
Kadar Logam Berat Timbal (Pb) pada Lipstik yang diperjualbelikan di Pasar Demangan Yogyakarta
Authors: Marola Finolia Silvia Magdalena , Prihatmo Guruh , Sutanto Haryati B.
Published: August 2022

Timbal (Pb) merupakan logam berat yang bersifat toksik bagi manusia. Cemaran timbal banyak dijumpai pada makanan, minuman dan kosmetik seperti lipstik. Dari beragam merk lipstik yang beredar di pasaran, terdapat beberapa merk yang tidak memiliki izin edar yang dikeluarkan oleh BPOM. Lipstik ilegal seperti ini banyak mengandung cemaran timbal. Penelitian ini bertujuan untuk mempelajari kandungan timbal dalam lipstik yang dijual di Pasar Demangan Yogyakarta. Pengambilan sampel lipstik berasal dari pedagang di dalam dan luar area Pasar Demangan. Sampel lipstik yang dianalisis dalam penelitian ini berasal dari 5 merk berbeda dengan pilihan warna lipstik adalah merah dan merah muda untuk masing-masing merk. Analisis sampel lipstik untuk setiap merk dan warna menggunakan 5 ulangan. Deteksi timbal dilakukan dengan metode Atomic Absorption Spectroscopy (AAS). Hasil uji AAS menunjukkan bahwa lipstik yang paling banyak mengandung Pb terdapat pada kode sampel LEP dengan kadar 3,37 mg/L, sedangkan lipstik yang sedikit mengandung Pb terdapat pada kode sampel LAP dengan kadar 2,24 mg/L. Lipstik yang di jual di Pasar Demangan layak untuk di gunakan oleh konsumen karena kadar timbal yang ada pada lipstik belum melebihi standar BPOM.
Sound Absorbent And Damping Rate of The Natural Composites Design
Authors: Kunthi Sekarani Andari , Hawa Baiq Siti , Auliya Firda
Published: August 2022

This research was conducted to determine the sound attenuation level of  composite. The composite used in this study iscompound Kalimantan sawdust and pineapple leaf fiber. The research objective was to determine the damping rate of composites (fine Kalimantan sawdust and compound of coarse Kalimantan sawdust with pineapple leaf fiber), so it can be used as an alternative sound absorbent material. The composite testing process uses a Sounds Level Meter by adjusting the frequency of the sound source. The space partition is a composite, measured the value of sound intensity at a certain distance, then given a partition, the sound intensity is again measured with the same distance. The results of the absorption coefficient of pineapple leaf fiber composite and red meranti wood sawdust can be used as an alternative sound absorbing material besides glass wool so that it can minimize side effects for public health. ©2018 JNSMR UIN Walisongo. All rights reserved.