bluuebunny/crossref_metadata_2025 huggingface dataset:
A Case Study in Tablet-Based Augmented Reality Vocabulary Acquisition
Authors: Dabrowski Adam
Published: April 2023

Augmented Reality (AR) is a novel technology capable of embedding digital objects a user's experience of reality via a smartphone, tablet, or head-mounted display. AR offers interesting pedagogical applications and research possibilities in the field of SLA, particularly in the deliberate study of vocabulary. Such applications also offer implications for distance learning. This case study examined a 25-year-old Japanese language teacher in her deliberate acquisition of three sets of 15 vocabulary items selected from the first 1,000 most frequent words of Basque. A word card study method was compared with two AR vocabulary study methods. One AR study method involved the study of physical objects and their signifying Basque vocabulary items within a context-independent scene which was unknown to the participant. The second AR study method similarly involved the study of physical objects and their signifying Basque vocabulary items within a context-dependent scene which was known to the learner. In terms of vocabulary retention as measured with meaning recognition, form recognition, and form recall tests, both AR methods of study appeared to be as effective if not more so than word cards. The study of vocabulary items represented by physical objects in a contextualized environment with the use of a tablet-based AR application was beneficial in leveraging the recall of meaning and form of those items. During reflective interviews regarding the use of AR the participant indicated that she found the novel method of vocabulary study to be engaging and motivating. The findings of this study also indicate that mobile AR applications have potential pedagogical uses relevant to distance education practices.
Perception of the UMak Academic Community in Utilizing the TBL Hub
Authors: Leaño April
Published: April 2023

The conduct of online classes has tremendously increased in the year 2020 because of the COVID-19 pandemic. In this regard, the education sector worldwide decided to conduct classes online which brought the birth of learning management systems (LMS) that allows a one-stop shop of essential online class tools for both teachers and students. The University of Makati introduced the Technology Based Learning Hub (TBL Hub) to its academe in the second semester of the school year 2020-2021. This study aims to analyze the perceived behavior of the UMak Academic community in utilizing the said LMS. The respondents of this paper are selected via purposive-total enumeration of the university’s College of Education. The quantitative-qualitative research analyzed the perception and evaluation of its respondents through a researcher-made questionnaire adapted from Alshorman and Bawaneh (2018) and Cunningham & Bradley (n.d.) based on the Technology Acceptance Model (TAM) authored by Fred Davis (2018). The results of the study revealed that the respondents' perceived usefulness in terms of course management and faculty-student and peer interaction and their evaluation of the ease of use in terms of the hub's implementation of the process has already achieved positive faculty acceptance. However, to analyze the more specific behavior of the end-users, the researcher recommends further research on faculty members' use of the LMS in their teaching based on their age, a device used, internet access, and experience in the use of other LMSs.
How Much do Investors Care about Social Responsibility?
Authors: Hirst Scott , Kastiel Kobi , Kricheli-Katz Tamar
Published: April 2023

Perhaps the most important corporate law debate over the last several years concerns whether directors and executives should manage the corporation to maximize value for investors or also take into account the interests of other stakeholders and society. But, do investors themselves wish to maximize returns, or are they willing to forgo returns for social purposes? And more broadly, do market participants, such as investors and consumers, differ from donors in the ways in which they prioritize monetary gains and the promotion of social goals? This project attempts to answer these questions with evidence from an experiment conducted with 279 participants that involved real monetary gains for participants. Our empirical analysis provides four main results: First, investors are generally willing to forgo some monetary gains to promote social interests. Second, individuals are willing to forgo greater amounts when consuming and making donations than when investing. Third, whereas most investors are willing to forgo gains to promote social interests, a significant percentage of investors (thirty-two percent in our study) have a strong preference for maximizing monetary gains and are unwilling to forgo even very small amounts to advance any social goals. Fourth, there is significant heterogeneity in individuals’ willingness to forgo in each of the three channels (investment, consumption, and donation), which is related to their political affiliation, gender, and income. Our evidence suggests that Democrats, women, and higher-income participants tend to forgo more frequently and in greater amounts compared to Republicans, men, and lower-income participants, though these relationships vary with the cause in question. These findings have important implications for the current debate regarding corporate social responsibility and for the actions of corporate executives and investment managers.
Epidemiological Workforce for Current and Future Pandemic Control
Authors: Chongsuvivatwong Virasakdi
Published: April 2023

Epidemiology is the frontline combatant discipline against COVID-19. Human's knowledge and technology evolve in parallel with the emergence of this and other coming pandemics. Modern epidemiologists must have a glimpse at various relevant scientific fields and employ them to tackle the problems. In order to shape up such competence for the new generation epidemiologists, the educational institutes must critically review the training curricula.
Investigation of a Methemoglobinemia Outbreak Caused by Eating Sausages with High Concentrations of Nitrates and Nitrites in Trang Province, Thailand, January 2022
Authors: Sangsawang Choopong , Chuaydamrong Nalinee , Luankaew Thawatchai , Thepparat Thidapon , Leesahud Nutjamee
Published: April 2023

In late January 2022, a cluster of methemoglobinemia cases across five provinces of Thailand was notified to the regional public health authorities. A joint investigation was conducted aiming to describe characteristics of the outbreak in one of the provinces, traceback the suspected food, and recommend prevention and control measures. We conducted a cross-sectional descriptive study, interviewing the cases, reviewing their medical records, and interviewing their parents and treating physicians. An active case finding was conducted. A probable case was defined as a person who presented with acute central cyanosis with oxygen saturation less than 92% by pulse oximetry. Suspected food samples were collected for nitrates and nitrites testing. Three cases (2 males, 1 female) were identified and there was no death. Their ages ranged from 8–12 years. The sausages came from the same source and were found to have high concentrations of nitrates (1,270.8–1,690.0 mg/kg) and nitrites (3,554.5–3,776.2 mg/kg). The sausages were identified as a likely cause of the outbreak. Government regulation, product liability laws, and food safety concerns among food retailers and customers are important to reduce the impact of consuming unsafe foods.
The Grammar of Science: How do We Count Time?
Authors: Kaewkungwal Jaranit
Published: April 2023

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Interplay between autophagy and coronavirus: autophagy mechanism
Authors: Elez-Burnjaković Nikolina , Smajlović Ajla , Dubravac Tanasković Milena
Published: April 2023

 

Regardless of the fascinating progress of humanity, biotechnology and medicine, the outbreak of the global pandemic of the SARS-CoV-2 virus has shown us that we are just as vulnerable as in previous eras when communicable diseases decimated the world’s population. But the discoveries made so far at the molecular level allow us to connect knowledge interdisciplinary and find solutions and therapeutic strategies where there seems to be no link. It was the previous coronavirus infections that served as a homologous model for finding the connection between the SARS-CoV-2 virus and autophagy. Autophagy, a conserved universal process of all eukaryotic cells responsible for cell survival under stressful circumstances, has been shown to play a significant role in viral invasions. It contributes to both direct and indirect antiviral responses such the elimination of viruses, the presentation of their antigens, and the reduction of inflammatory responses. The autophagy machinery of host cells can, however, be suppressed, evaded, or used by viruses to their benefit. Therefore, autophagy has an ambiguous role in coronavirus-related infections, especially in COVID-19.

 
Influence de la Télévision sur la Délinquance Juvénile à Kinshasa (RD Congo) et Thérapie Sociale: Etude Menée dans le Quartier Kingasani
Authors: Massikini Elie Mary-Joe
Published: April 2023

La présente étude avait pour but d’analyser l’influence de la télévision sur la délinquance juvénile communément appelée Kuluna à Kinshasa. En vue de trouver une solution durable à ce malaise social, une enquête selon la technique d’échantillonnage aléatoire simple a été réalisée auprès de 1700 sujets, pour la plupart jeunes, dont l’âge variait entre 13 ans à 26 ans, dans lequel il y a 844 individus de sexe masculin et 836 individus de sexe féminin, tiré de la population du quartier Kingasani dont la taille s’élève à 17 000 habitants. Les résultats de cette étude indiquent que la télévision joue un rôle socialement pervers. La violence dans la strate sociale de jeunes et le média, principalement la télévision à travers ses chaines, contribuent à la production sociale de la délinquance juvénile en milieu pauvre Kinois. La famille joue ainsi un rôle important dans la mise en place d’une communication intrafamiliale susceptible de protéger les enfants contre l’influence des chaines télé-visualisées sur l’éthologie et la violence chez les jeunes. Mots clés: Communication intrafamiliale, Phénomène Kuluna, déterminants sociaux, loi dialectique, démission parentale
Organización Económica y Desarrollo Regional del Estado de Hidalgo: Pasado y presente
Authors: Roldán Cruz Edgar Iván
Published: April 2023

El presente trabajo tiene como objetivo prioritario determinar el origen de la causalidad y la actualidad de la organización espacial de la economía hidalguense. El análisis pondera la comparación con la estructura productiva de la economía mexiquense y del Distrito Federal. Se identifica, bajo el modelo agrario exportador y modelo de industrialización por sustitución de importaciones, las tendencias a largo plazo de la economía hidalguense que permitan, al llegar al modelo que impera en la actualidad, determinar quiebres y
continuidades. Posteriormente se analiza la causalidad actual que manifiesta la economía hidalguense y la organización espacial del estado, en confrontación con la dinámica que presenta la región centro del país.
Elektronik Kayıt Sistemlerinin Hemşirelik Uygulamalarında Kullanımı ve Önemi
Authors: GÜRKAN Nurdan , ENÇ Nuray , TÜREN Sevda
Published: April 2023

Modern sağlık sistemleri, sağlık hizmeti sağlayıcılarının nitelik ve niceliğini artırmak için bilgi ve iletişim teknolojilerinin birçok avantajından yararlanır. Teknoloji ile birlikte gelişen ve değişen sağlık sistemlerinde bilgi ve iletişim teknolojilerinin kullanımı hızla artmaktadır. Sağlık bilişimi, bilgi ve iletişim teknolojilerinin sağlık hizmeti sunucularına kaliteli bakım sağlamak, iş yüklerini azaltmak, güvenli kayıt tutmayı sağlamak, kişisel ve mesleki gelişimlerini kolaylaştırmak için kullanılması nedeniyle önemlidir. Sağlık bakımı ortamlarında klinik bilgiyi kullanan en büyük grubu hemşireler oluşturmaktadır. Hemşirelik uygulamalarında bilgi geliştirmek ve bakım standartlarını artırmak için yeni teknolojilerin ve elektronik kayıtların kullanılması önemlidir. Bu derlemede hemşirelik bilişiminin ve elektronik kayıt sistemlerinin klinik ortam içinde hemşirelik uygulamalarında kullanımının önemi açıklanmıştır. İncelenen çalışmalar kapsamında hemşirelerin, hemşirelik uygulamalarında teknoloji kullanımına adapte olduğunu ancak elektronik sağlık kayıtlarının kendi alanlarındaki uzman kişiler tarafından geliştirildiğinde çok daha etkili ve verimli olacağını, dolayısıyla Bilişim Hemşirelerine çok daha fazla ihtiyaç olduğu ve bu sayede verilen sağlık hizmetinin kalitesinin daha da artacağını öngörmekteyiz.
Sosyal Medya Fenomeni Hemşireler Tarafından Üretilen İçeriklerin e-Profesyonelliğe Etkisi Üzerine Bir Derleme
Authors: NAZİK Gamze , ŞAHİNER Esra , BOZ İlkay
Published: April 2023

Sosyal medyanın hayatımızın her alanında hızla yayıldığı ve bu platformlardaki gönderilerin oldukça geniş kitlelere ulaşabildiği bilinmektedir. Bu geniş kitleler arasında yer alan hemşirelerin çoğu aktif olarak sosyal medyayı kullanmaktadır. Hemşirelerin sosyal medya platformlarında ürettiği içeriklerin daha çok eğlence ve eğitim amaçlı olduğu anlaşılmaktadır. Bu platformlarda hemşirelerin içerik paylaşımları ve bunlara yapılan yorumların toplumda hızla yayılmasının meslek imajını etkileyebileceği, bazı durumlarda da bu imaja zarar verme olasılığı göz önüne alınmalıdır. Sosyal medya fenomeni hemşirelerin paylaştıkları içeriklerin, hemşireliğin e-profesyonelliği üzerine etkileri bilinmelidir. Sosyal medya paylaşımlarının olumsuz etkisinin azaltılması ve olumlu paylaşımların artması için neler yapılması gerektiği üzerinde düşünmemiz gereken konulardandır. Ülkemizde sosyal medyada içerik üreten influencer/fenomen hemşirelerin toplumun, hemşirelerin ve öğrenci hemşirelerin hemşirelik mesleğine bakış açısının ve hemşirelik imajına etkisinin incelenmesi ile ilgili bilgimiz dahilinde bir çalışmaya ulaşılamamıştır. Bu derlemenin amacı sosyal medya fenomeni hemşirelerin ürettikleri içeriklerin e-profesyonelliğe etkisini incelemek ve bu alanda farkındalık oluşturmaktır. Ülkemizde sosyal medya fenomeni hemşirelerin paylaşımlarının e-profesyonelliğe etkileri üzerine çalışmalar yapılması ve hemşireler için sosyal medya kullanım rehberlerinin geliştirilmesi önerilmektedir.
Yenidoğan Döneminde Paternal Bağlanmanın Önemi ve Baba Dostu Hemşirelik Uygulamalarının Sürece Etkisi: Geleneksel Derleme
Authors: SAĞLAM Duygu , İŞLER DALGIÇ Ayşegül
Published: April 2023

Paternal bağlanma (baba-bebek bağlanması), doğum sonrası ikinci-üçüncü günde başlayıp bir aylık süreç sonucunda gerçekleşen baba ve bebek arasındaki karşılıklı ilişkidir. Sağlıklı bir baba-bebek bağlanmasının oluşabilmesi için babanın ilk bir yıllık süreçte bebek bakımına doğrudan katılması gerekmektedir. Baba-bebek bağlanması ilk günlerden itibaren oluşan bebeklerde; duygusal, bilişsel ve sosyal becerilerinin daha iyi olduğu belirlenmiştir. Paternal bağlanmanın doğum sonrası gelişmeye başlaması nedeniyle özellikle yenidoğan yoğun bakım ünitelerinde yatan bebekler ve babaları bu süreçten olumsuz etkilenmektedirler. Bebeği yenidoğan yoğun bakım ünitesine yatırılan baba yoğun bakım ünitesine geldiğinde genellikle duyduğu ilk sözler “Babası bebeğiniz hayırlı olsun, sizden ıslak mendil ve bez istiyoruz” cümlesi olmuştur. Ancak babalık rolü maddesel olarak metalaştırılan, ekonomik kaynak olarak görüldüğü bu profilden çok daha fazlasıdır. Yenidoğan hemşireleri baba-dostu hemşirelik uygulamaları ile paternal bağlanma sürecinin gelişimini destekleyebilirler. Bu derleme makalede yenidoğan sağlığı açısından anne-bebek-baba sağlık ekseninde paternal bağlanmanın öneminin vurgulanması ve hemşireler tarafından uygulanabilecek baba dostu girişimler hakkında bilgi verilmesi amaçlanmıştır.
Danmark – landet med de store virksomheder
Authors: Iversen Martin Jes
Published: April 2023

I takt med globaliseringen efter 1990 er den danske erhvervsstruktur gradvist blevet præget af en lille skare, meget store virksomheder. Denne udvikling står i skærende kontrast til den traditionelle opfattelse af Danmark som et land præget af små og mellemstore virksomheder i modsætning til nabolandene Sverige og Tyskland. Med fokus på Novo Nordisk konkluderes det, at selv enkelte virksomheder har kritisk betydning for landets økonomi, blandt andet i forhold til skattebetaling, formueafkast og afledt beskæftigelse. Hvor hidtidige magtudredninger har haft fokus på de mere strukturelle forhold, så bør koncentrationstendenserne i dansk erhvervsliv føre til et supplerende fokus på de enkelte storkoncerners betydning for den danske økonomi samt følgende magtposition i det danske samfund. Det er værd at bemærke, at de største danske virksomheder repræsenterer flere forskellige sektorer inden for blandt andet transport, service samt medicinal- og fødevarebrancherne.
Magt og den danske aftalemodel
Authors: Høgedahl Laust , Ibsen Christian Lyhne
Published: April 2023

Arbejdsmarkedet er en helt central arena for magt og magtudøvelse, hvor lønmodtagere og virksomhederne kæmper om den værdi, der skabes. I Danmark findes imidlertid en række aftaler, normer og institutioner – populært kaldet ”Den danske model” – der sætter afgørende rammer for magtanvendelse på arbejdsmarkedet. I denne artikel fokuserer vi på, hvordan magt anvendes og udøves på det danske arbejdsmarked med et fokus på forskelle mellem den offentlige og den private sektor. Motivationen for denne sammenligning stammer især fra udviklingen i konfliktniveauet (målt på tabte arbejdsdage), hvor den offentlige sektor de sidste to årtier tegner sig for hovedparten af konflikter på arbejdsmarkedet. Den offentlig sektor er særlig (teoretisk) interessant i et magtperspektiv, da sektoren netop er politisk styret, modsat den private sektor, hvor det er markedskræfterne, der sætter den afgørende rammebetingelse.
Sjællands kvaler
Authors: Lotz Peter
Published: April 2023

København er i rivende udvikling, mens der er stagnation på den anden side af Sjælland. Fødselstallet i Vest- og Sydsjælland er lavere nu end for 20 år siden. I København er det fordoblet. Antallet af arbejdspladser udvikler sig tilsvarende forskelligt. Det er en overraskende udvikling. For København var for 30 år siden både befolkningsmæssigt og erhvervsmæssigt i krise. Dette essay trækker trådene tilbage til den industrielle revolution i anden halvdel af 1800-tallet for at finde baggrunden for denne udvikling og påpeger, hvordan byens fysiske rammer, befolkningens uddannelse og markante ændringer i produktionsvilkårene har dannet rammerne for en selvforstærkende, positiv udvikling i København. Parallelt hermed ses Vestog Sydsjælland som et område uden en tilsvarende dynamik, hvis fremtid er knyttet op på Københavns fortsatte udvikling.
Une approche transdisciplinaire de la problématique de la mobilité scolaire à Mons (Belgique)
Authors: Durieux Marianne , Pouleur Jean-Alexandre , Scoubeau Chantal
Published: April 2023

À partir d’un cas d’étude d’urbanisme complexe actuel, celui des problèmes d’accessibilité des implantations scolaires d’une ville moyenne belge (Mons), une proposition d’analyse transdisciplinaire des déplacements entre le domicile et l’école est présentée. Ce phénomène observé émerge de différentes données de terrain, dont les retours des citoyens lors d’un processus participatif. Pour appréhender ce phénomène, la méthodologie utilisée est inductive-abductive : en s’appuyant sur le terrain, des abductions sont élaborées et ensuite confrontées à des concepts théoriques existants. La question de recherche est donc celle-ci : comment la transdisciplinarité aide-t-elle à théoriser l’accessibilité des établissements scolaires à Mons? En premier lieu, l’article présente le phénomène observé et le cadre théorique. Ensuite, le processus de recherche cyclique entre les données de terrain, les abductions et les concepts théoriques empruntés à différentes disciplines (l’architecture, la géographie et la sociologie urbaine) est détaillé. Enfin, l’intérêt de l’approche systémique et transdisciplinaire est montré pour le phénomène observé.
Anomalously light geological complex on the watershed plain of the Yano-Indigir lowland
Authors: Petrov Aleksandr Nikolaevich
Published: April 2023

The research method is a purposeful petrophysical interpretation of the gravitational field. The object under study appeared during prospecting geological and geophysical work as a hindrance to the solution of the main geological problem. Its density is 1 g/cm3, the height of the sole is 35 m, the area is 1420 km2, the volume is 20 km3. The object is defined as an abnormally light Ice Complex (ALIC). The revealed density is explained by peat-ice performance. In ALIC, a near-surface lenticular-layered formation ice has been uncovered, the structure of which indicates the generation of the mass of the complex ahead of sedimentation. The gravimetric data, the landscape and the details of the ALIC structure are interconnected and make up the first — the most complete view of the complex at the moment. The main elements of the presentation are the three phases of the development of the complex. The first is classical, generally accepted for polygonal—vein structures, the second differs from the classical one by the absence of frost-breaking cracking, the third is the growth of formation ice. The qualitative difference of the thermophysical components of the cryolithozone of the territory is given, which made it possible to introduce several concepts concerning the generation of peat-ice mass ALIC. Such as: heat dissipation capacity of the middle layer, stabilization of the zero isotherm at the petrophysical boundary; conditions for the beginning of the growth of lenticular-layered ice; accelerated lateral segregation growth of powerful ice veins; constancy of the thermal resistance of the cryolithozone. On the basis of these concepts, models of the development of the second and third phases of ALIC are compiled, and a view on the theory of the formation of cover glaciers is formed, which follows from the model of the third phase. The novelty of the research consists: in identifying a unique petrophysical object, in defining this object as ALIC, in identifying an ice massif on the territory of ALIC, in presenting the development of the complex as a sequence of three phases, in compiling models of the second and third phases of ALIC and in an original approach to the formation of cover glaciers.
Kazrin promotes dynein/dynactin-dependent traffic from early to recycling endosomes
Authors: Hernandez-Perez Ines , Rubio Javier , Baumann Adrian , Girao Henrique , Ferrando Miriam , Rebollo Elena , Aragay Anna M , Geli María Isabel
Published: April 2023

Kazrin is a protein widely expressed in vertebrates whose depletion causes a myriad of developmental defects, in part derived from altered cell adhesion and migration, as well as failure to undergo epidermal to mesenchymal transition. However, the primary molecular role of kazrin, which might contribute to all these functions, has not been elucidated yet. We previously identified one of its isoforms, kazrin C, as a protein that potently inhibits clathrin-mediated endocytosis when overexpressed. We now generated kazrin knock-out mouse embryonic fibroblasts to investigate its endocytic function. We found that kazrin depletion delays juxtanuclear enrichment of internalized material, indicating a role in endocytic traffic from early to recycling endosomes. Consistently, we found that the C-terminal domain of kazrin C, predicted to be an intrinsically disordered region, directly interacts with several early endosome (EE) components, and that kazrin depletion impairs retrograde motility of these organelles. Further, we noticed that the N-terminus of kazrin C shares homology with dynein/dynactin adaptors and that it directly interacts with the dynactin complex and the dynein light intermediate chain 1. Altogether, the data indicate that one of the primary kazrin functions is to facilitate endocytic recycling by promoting dynein/dynactin-dependent transport of EEs or EE-derived transport intermediates to the recycling endosomes.
CHD-associated enhancers shape human cardiomyocyte lineage commitment
Authors: Armendariz Daniel A , Goetsch Sean C , Sundarrajan Anjana , Sivakumar Sushama , Wang Yihan , Xie Shiqi , Munshi Nikhil V , Hon Gary C
Published: April 2023

Enhancers orchestrate gene expression programs that drive multicellular development and lineage commitment. Thus, genetic variants at enhancers are thought to contribute to developmental diseases by altering cell fate commitment. However, while many variant-containing enhancers have been identified, studies to endogenously test the impact of these enhancers on lineage commitment have been lacking. We perform a single-cell CRISPRi screen to assess the endogenous roles of 25 enhancers and putative cardiac target genes implicated in genetic studies of congenital heart defects (CHDs). We identify 16 enhancers whose repression leads to deficient differentiation of human cardiomyocytes (CMs). A focused CRISPRi validation screen shows that repression of TBX5 enhancers delays the transcriptional switch from mid- to late-stage CM states. Endogenous genetic deletions of two TBX5 enhancers phenocopy epigenetic perturbations. Together, these results identify critical enhancers of cardiac development and suggest that misregulation of these enhancers could contribute to cardiac defects in human patients.
Transcriptomic profiling of tissue environments critical for post-embryonic patterning and morphogenesis of zebrafish skin
Authors: Aman Andrew J. , Saunders Lauren M. , Carr August A. , Srivatsan Sanjay R. , Eberhard Colten D. , Carrington Blake , Watkins-Chow Dawn , Pavan William J. , Trapnell Cole , Parichy David M.
Published: April 2023

Pigment patterns and skin appendages are prominent features of vertebrate skin. In zebrafish, regularly patterned pigment stripes and an array of calcified scales form simultaneously in the skin during post-embryonic development. Understanding mechanisms that regulate stripe patterning and scale morphogenesis may lead to discovery of fundamental mechanisms that govern development of animal form. To learn about cell types and signaling interactions that govern skin patterning and morphogenesis we generated and analyzed single cell transcriptomes of skin from wild-type fish as well as fish having genetic or transgenically induced defects in squamation or pigmentation. These data reveal a previously undescribed population of epidermal cells that express transcripts encoding enamel matrix proteins, suggest hormonal control of epithelial-mesenchymal signaling, clarify the signaling network that governs scale papillae development, and identify a critical role for the hypodermis in supporting pigment cell development. Additionally, these comprehensive single-cell transcriptomic data representing skin phenotypes of biomedical relevance should provide a useful resource for accelerating discovery of mechanisms that govern skin development and homeostasis.
Extracts from Acta Literaria et Scientiarum Sveciæ, Volumen Tertium (1730–1734)
Authors: Hallman Johan Göstaf , Celsius Anders , Spöring Herman , Hof Sven
Published: April 2023

The file is a facsimile of extracts from the third volume of the Acta Literaria et Scientiarum Sveciae, comprising all articles on the aurora borealis in issues of the journal covering the years 1730 to 1734. For a detailed summary of contents, see the introduction by Per Pippin Aspaas.
A systematic review of Homoeopathic Treatment for insomnia
Authors: Bhat Ketaki , Jadhav Arun
Published: April 2023

Insomnia is one of the most frequently countered condition, yet it is the most neglected condition as well. The review of articles published and various studies done on treatment of insomnia with homoeopathy is essential to know the utility and effectiveness of Homoeopathic treatment. The other methods of treatment for insomnia are responsible for drug dependence and many adverse effects. Numerous articles were studied from electronic databases like Medline, PubMed, SCOPUS etc. The detailed study of various types of articles were done based on Homoeopathy and insomnia to know the effectiveness of the homoeopathic drugs. Total 6123 articles were studied and depending on criterion for inclusion and exclusion a total of 36 publications were chosen for the investigation. The study concludes that Homoeopathic treatments are effective and long term beneficial though more research is necessary.
Treatment of hyperkeratotic lesions, primarily focusing on corns with the aid of various techniques, mainly emphasizing on homeopathy- an overview.
Authors: Amreen Sumiyya R  , Rajendra Eknath Shinde
Published: April 2023

Corns are also known as localized plantar hyperkeratosis of skin, is one of the most common diseases in young adults and old people throughout the world. It falls under the category of superficial disorders occurring in the foot. It is caused by the hyperactivity of keratinocytes, that is to say, the hyperkeratotic activity of stratum corneum or rapid proliferation of keratinocytes, resulting in the formation of thickened layers of skin. The major mechanical cause for the development of corn is faulty footwear, congenital deformities in the foot viz... A mallet toe, hammertoe and claw toes. A broad forefoot that has been forcefully constricted in the toe box could be one of the most common causes for the development of Corn. The common symptoms associated with corn are pain, impaired mobility and limited functional activities. Common site of the appearance of Corn is palm, soles of feet, knees, balls of the heel. On assessment, it is observed that 14 -48 % of people experience the sufferings of Corn. 33-78% of older age group people over 75 years of age experience these hyperkeratotic lesions.  Here we are going to discuss the existing literature describing various methods that are used while treating hyperkeratotic lesions, especially of Corn. The following literature concisely provides different procedures opted to excavate the Corn, either conservatively or operatively, using Homoeopathy or modern medicine respectively. In this review of the literature, we are going to exhibit the effectiveness of homoeopathic medicine over other conventional methods of treatment. This article will review a few of the literature work done under the condition of hyperkeratotic lesions mainly emphasizing the treatment of Corns by using various techniques in various systems of medicine.
Treatment of essential hypertension with homoeopathy- an overview
Authors: Srivani Duvvuri Valli , Patil Anita S.
Published: April 2023

Arterial pressure is essential for sustaining life, at the same time, an elevated blood pressure can be most inimical to life, if persisting over a period of time. In more than 95% of cases, a specific underlying cause of hypertension cannot be found. Their condition is referred to as essential hypertension. Now a days, in the name of modernization, present day generation has brought about a lot of changes in life style and environment. These external forces interact with mental and emotional state of a person to produce certain degree of stress which has made “TENSION” become one’s friend in day to day modern life. People are pushing themselves harder at the price of their health with target-oriented jobs and competitiveness making life more sophisticated. Lifestyles have become sedentary and people are developing unhealthy habits like smoking and drinking from an early age. This is making individuals more vulnerable to illness. Hypertension is common, asymptomatic and leads to lethal complications if left untreated. So early the hypertension detected, more the chances to prevent organ damage. Here we are going to discuss the existing literature and work done in the Essential Hypertension condition and also the effectiveness ofHomoeopathic treatment.
Focal Nodular Hyperplasia of the Liver without a Central Scar: A Rare Case Report
Authors: Singh Gyanendra , Singh Anurag , Jain Manoj , Kalonia Tushar
Published: April 2023

Focal Nodular Hyperplasia (FNH) is most frequent benign tumour of liver just after the haemangioma, which makes about 3%-5% of all primary hepatic tumours. It occurs frequently in females during their middle age group. This is case report of 48-year-old female patient having complains of upper abdominal pain since last one year. Using abdominal ultrasonography and a CT scan, it was discovered that segment four of the liver contained a tumour measuring 11 cm in maximum diameter without a central scar, which made preoperative imaging scans for FNH difficult to diagnose. Lobectomy of left lobe was done. The gross specimen on cut section revealed a lesion with nodular appearance and absence of any central stellate scar. On the basis of histopathological finding the diagnosis of FNH without central stellet scar was made. To ensure adequate therapy, it is essential to differentiate between FNH and other hyper vascular liver lesions and metastases. Therefore, it is difficult to diagnose FNH before surgery if there are no typical radiological findings. This case report focused on FNH without the usual radiological findings and emphasised its importance to distinguish it from other malignant hyper vascular liver entities.
Correlation Between Serum Ferritin Levels and Echocardiographic Changes in Children with Beta-thalassaemia MajorA Cross-sectional Analytical Study
Authors: Das Eshita , Karar Neha , Halder Dipanjan , Biswas Prativa , Naskar Arghya Roy
Published: April 2023

Introduction: Heart failure secondary to iron overload is the leading cause of mortality in patients with beta-thalassaemia major. Prevention of myocardial siderosis is a key step to reducing the rate of mortality in thalassaemia children. Aim: To study the correlation between serum ferritin levels and echocardiography parameters in children with beta-thalassaemia major. Materials and Methods: This cross-sectional analytical study was conducted in the Department of Paediatrics, RG Kar Medical College and Hospital, Kolkata, India from March, 2020 to July, 2021. A total of 85 beta-thalassaemia major children aged between 2-12 years without having any active infections or congenital heart diseases, were included in this study. Blood samples were obtained from these children for serum ferritin level assessment and echocardiography was performed to evaluate their cardiac function. Data were statistically analysed using the Chi-square test. Results: The mean age of patients was 7.24±2.76 years and the age range was 1-12 years. Mean serum ferritin levels in the study was 1938.67±992.57 and more than three-fourth of our population had serum ferritin levels more than 1000 ng/ mL. A 30% of present study population had abnormal echo findings. A significant correlation was noted between serum ferritin levels and echo parameters like Fractional Shortening (FS), Deceleration Time (DT), Early and Late Ratio (E/A ), Left Ventricular Mass (LV Mass). But negative correlation was found between serum ferritin levels and Ejection Fraction (EF). Conclusion: The present study concluded that due to the significant correlation between serum ferritin levels and echocardiographic parameters, it is beneficial to conduct echocardiography in all patients of beta thalassaemia major in their first decade to gain a better understanding of cardiac function.
Водяной орех в Манжерокском озере, "Природа"
Authors: Ситникова В.А. , Любимов Р.В. , Савенко К.С. , Кивацкая А.В.
Published: April 2023

В статье представлены новые данные об ареале произрастания водяного ореха плавающего (Trapa natans) в акватории Манжерокского озера. Приведена краткая ретроспектива изученности структуры озерных растительных сообществ. Оценено современное состояние группировки ореха плавающего и водной растительности водоема. Приведены рекомендации по восстановлению ареала водяного ореха.
Устойчивость к антидепрессантам: почему возникает и что с этим делать?, "Природа"
Authors: Цыбко А.С.
Published: April 2023

Устойчивость к антидепрессантам — один из самых больших вызовов для современной нейрофармакологии. В статье предлагается взглянуть на проблему с точки зрения серотониновой системы. Каковы ее особенности и как они могут обуславливать терапевтическую резистентность Кроме того, отдельное внимание уделено рецепторам серотонина, удивительная биология которых не только проливает свет на механизмы депрессивных расстройств, но и обещает дать ключ к их эффективной терапии.
Записки о дальневосточном лесном коте, "Природа"
Authors: Ткаченко К.Н.
Published: April 2023

В статье приведены новые данные об отдельных сторонах экологии дальневосточного лесного кота (способы охоты, использование поселений азиатского барсука, взаимоотношения с хищными птицами и млекопитающими и др.), собранные преимущественно на сельскохозяйственных землях приустьевой части р.Уссури в междуречье ее правых притоков Кии и Чирки и в восточной части Приханкайской низменности. Выявлено, что за последние 23 года в южном Приамурье (возможно, по всему ареалу на юге Дальнего Востока России) его численность несколько возросла. Он успешно приспособился к жизни в сельскохозяйственном ландшафте. Также уточнены особенности окраски больших подошвенных подушечек передних и задних лап кота. Установлено, что у некоторых особей, добытых в приустьевой части р.Уссури в междуречье Кия—Чирки, в промежутке между подушечками пальцев и большой подошвенной подушечкой имеются пятна белой шерсти. Ранее подобного признака в окраске кота не отмечали.
Разрез четвертичных отложений «Альбатрос», "Природа"
Authors: Комаров В.Н. , Вайтиева Ю.А. , Горячев И.А. , Думнова А.А.
Published: April 2023

Приведены данные изучения обнажения четвертичных отложений, расположенного на побережье Казантипского залива, в окрестностях поселка Новоотрадное, в 300 м к юго-юго-востоку от гостевого дома «Альбатрос». Исследованные континентальные породы, скорее всего, имеют элювиальное происхождение. Тем не менее, наличие в них значительного количества песка может указывать на участие в их формировании делювиального процесса — размыва временными потоками коренных пород на расположенных южнее возвышенностях, а кроме того — на активную эоловую деятельность, следы которой проявляются в виде пылеватых высококарбонатных лессовидных суглинков. Формирование отложений, по всей видимости, происходило во время среднесуббореального потепления (4800–3400 лет назад) и совпало с периодом возрастающей аридизации климата.
ЛАБОРАТОРИЯ Н.И. ТИХОМИРОВА, "Земля и Вселенная"
Authors: Судаков В.С.
Published: April 2023

1 марта 2021 г. исполнилось 100 лет со дня открытия первой в России научно-исследовательской и опытно-конструкторской организации по разработке снарядов на бездымном порохе – Лаборатории по разработке изобретений Николая Ивановича Тихомирова.
РЫНОЧНОЕ ПРАВО В МАНОРЕ, "Средние века"
Authors: Винокурова М.В.
Published: April 2023

В статье – преимущественно на основе изучения протоколов манориальной курии Рамсейского аббатства за 1275 г., опубликованных Ф.У. Мейтлендом – исследуется вопрос о специфике становления поселения Сент-Айвз, со времен Книги Страшного суда являвшегося манором, получившим в XIII в. от Генриха I королевскую франшизу на проведение в нем ярмарки. Проведение ярмарки было связано с формированием местного рыночного права, которое вытекало из непосредственных купеческих тяжб и судебных процессов по поводу различных казусов, призванных удовлетворить конкретные повседневные нужды сторон, представленных в спорах торгового люда. Специфическое правовое развитие Сент-Айвз выражалось в дуализме правовых компетенций местной курии. Это поселение, несмотря на, казалось бы, проявление в его социальной «жизнедеятельности» черт, связанных с активностью купечества и чертами городского развития, все же с административно-правовой точки зрения (самое наличие курии и специфика ее деятельности) в изучаемый период было организовано по манориальному принципу. В то же время деятельность местного суда здесь имела важную особенность: в курии, наряду с типичными тяжбами простого люда, более всего рассматривались дела, связанные с рыночным правом, то есть казусы, относящиеся к разбирательствам, которые порождались «рыночной действительностью» Сент-Айвз. Особенностью изученных документов явилось также то обстоятельство, что в них зафиксировано достаточно редкое для правовой сферы манориальной жизни XIII в. явление – участие в тяжбах как поверенных (адвокатов), так и целых групп свидетелей и представителей разного рода «партий», выступающих на стороне истца или ответчика.
РАЗВИТИЕ И ПРИМЕНЕНИЕ КОНЦЕПЦИИ ОЦЕНКИ ЖИЗНЕННОГО ЦИКЛА, "Энергия: экономика, техника, экология"
Authors: Авраменко А.А. , Денисова С.Д.
Published: April 2023

Вызовы в экологической сфере, стоящие перед человечеством, требуют новых, более эффективных и дальновидных управленческих решений, основанных на научных данных. Без учёта факторов изменения климата, исчерпания природных ресурсов, загрязнения окружающей среды, в том числе отходами производства и потребления, невозможно выбрать сценарий устойчивого развития территории или организации. При этом анализ экологических аспектов должен быть целостным и системным, охватывать все стадии так называемого жизненного цикла продукта.
Correlation between Fetal Kidney Length and Gestational Age among Pregnant Women Attending Image Diagnostic Centre, Port-Harcourt, Nigeria
Authors: Bob-Manuel Ibinabo Fubara , Adheke Oghenefego Michael , Ekeanyanwu Lovelyn Onyinyechi
Published: April 2023

Background: The obstetric management of a pregnancy depends on the knowledge of an accurate gestational age particularly in unregistered case.

Aim: The aim of the study is determine how accurately fetal kidney length (FKL) could estimate gestational age (GA) using ultrasonography.

Materials and Methods: The study involved 200 participants with 20 to 40 weeks pregnancies, referred to the Radiology Department of Image Diagnostic Center, Rumuola Port Harcourt for obstetric ultrasound scan, within a three-month period. The left and right fetal kidney lengths were measured and data obtained were analyzed using SPSS version 23.0. Linear regression equations were deduced.

Results: There was no statistically significant difference between the measurements of the right and left kidneys. There was a strong positive correlation between gestational age (GA) and right kidney length (RKL) (r = .998, p < 0.01) and left kidney length (LKL) (r = .998, p < 0.01). Regression formulae used for predicting GA using right and left FKL was 9.9494(RKL) + 0.3058, and 9.9404(LKL) + 0.3468, respectively.

Conclusion: FKL proved to be a reliable predictor of gestational age of pregnancies in the second and third trimesters.
Global Policy and Practice for Intrauterine Fetal Resuscitation During Fetal Surgery for Open Spina Bifida Repair
Authors: Gallagher Katie , Crombag Neeltje , Prashar Kavita , Deprest Jan , Ourselin Sebastien , David Anna L. , Marlow Neil
Published: April 2023

Importance

Globally accepted recommendations suggest that a woman should be between 19 weeks and 25 weeks plus 6 days of pregnancy to be considered eligible for fetal closure of open spina bifida. A fetus requiring emergency delivery during surgery is therefore potentially considered viable and thus eligible for resuscitation. There is little evidence, however, to support how this scenario is addressed in clinical practice.

Objective

To explore current policy and practice for fetal resuscitation during fetal surgery for open spina bifida in centers undertaking fetal surgery.

Design, Setting, and Participants

An online survey was designed to identify current policies and practices in place to support fetal surgery for open spina bifida, exploring experiences and management of emergency fetal delivery and fetal death during surgery. The survey was emailed to 47 fetal surgery centers in 11 countries where fetal spina bifida repair is currently performed. These centers were identified through the literature, the International Society for Prenatal Diagnosis center repository, and an internet search. Centers were contacted between January 15 and May 31, 2021. Individuals volunteered participation through choosing to complete the survey.

Main Outcomes and Measures

The survey comprised 33 questions of mixed multiple choice, option selection, and open-ended formats. Questions explored policy and practice supporting fetal and neonatal resuscitation during fetal surgery for open spina bifida.

Results

Responses were obtained from 28 of 47 centers (60%) in 11 countries. Twenty cases of fetal resuscitation during fetal surgery during the last 5 years were reported across 10 centers. Four cases of emergency delivery during fetal surgery after maternal and/or fetal complications during the last 5 years were reported across 3 centers. Fewer than half the 28 centers (n = 12 [43%]) had policies in place to support practice in the event of either imminent fetal death (during or after fetal surgery) or the need for emergency fetal delivery during fetal surgery. Twenty of 24 centers (83%) reported preoperative parental counseling on the potential need for fetal resuscitation prior to fetal surgery. The gestational age at which centers would attempt neonatal resuscitation after emergency delivery varied from 22 weeks and 0 days to more than 28 weeks.

Conclusions

In this global survey study of 28 fetal surgical centers, there was no standard practice about how fetal resuscitation or subsequent neonatal resuscitation was managed during open spina bifida repair. Further collaboration between professionals and parents is required to ensure sharing of information to support knowledge development in this area.
The International Map of Axial Spondyloarthritis Survey: A US Patient Perspective on Diagnosis and Burden of Disease
Authors: Magrey Marina , Walsh Jessica A. , Flierl Sandra , Howard Richard A. , Calheiros Renato C. , Wei David , Khan Muhammad A.
Published: April 2023

Objective

Axial spondyloarthritis (axSpA) is a chronic inflammatory disease that causes inflammation in the axial skeleton, resulting in structural damage and disability. We aimed to understand the effect of axSpA on work activity, day‐to‐day function, mental health, relationships, and quality of life and to examine barriers to early diagnosis.

Methods

A 30‐minute quantitative US version of the International Map of Axial Spondyloarthritis survey was administered online to US patients aged 18 years and older with a diagnosis of axSpA who were under the care of a health care provider from July 22 to November 10, 2021. This analysis describes demographics, clinical characteristics, journey to axSpA diagnosis, and disease burden.

Results

We surveyed 228 US patients with axSpA. Patients had a mean diagnostic delay of 8.8 years, with a greater delay in women versus men (11.2 vs. 5.2 years), and 64.5% reported being misdiagnosed before receiving an axSpA diagnosis. Most patients (78.9%) had active disease (Bath Ankylosing Spondylitis Disease Activity Index score ≥4), reported psychological distress (57.0%; General Health Questionnaire 12 score ≥3), and experienced a high degree of impairment (81.6%; Assessment of Spondyloarthritis International Society Health Index score ≥6). Overall, 47% of patients had a medium or high limitation in activities of daily living, and 46% were not employed at survey completion.

Conclusion

The majority of US patients with axSpA had active disease, reported psychological distress, and reported impaired function. US patients experienced a substantial delay in time to diagnosis of axSpA that was twice as long in women versus men.