bluuebunny/crossref_metadata_2025 huggingface dataset:
Education about the importance of infant’s basic immunizations for pregnant and lactating mothers
Authors: Hasan Wahyuni , Aulia Farikha , Fuad Mohammad , Siampa Imanuelle Tamara Audrey , Rustam Sitti Nailah , Saputri Eka Ernalifia , Suarso Muhammad Aksin , Radiah Radiah , Nildawati Nildawati , Ikhsan Muhammad , Rachmat Muhammad
Published: July 2022

One of the causes of neonatal and infant deaths in Indonesia is vaccine-preventable diseases (PD3I). Since the COVID-19 pandemic, the number of people visiting posyandu (integrated healthcare center) in Bontokassi Village has been reduced. It is probably due to a fear of contracted Covid-19 emerged among the community when coming to posyandu. In addition to low vaccine availability for infants, lack of maternal knowledge is one of the causes of the low vaccination rates among infants in this village. This education was aimed to increase maternal knowledge about the importance of basic immunization for infants to prevent diseases. The result showed increased maternal understanding of the importance of basic immunization after the education program was given.
ACTIVITY TEST OF A LIQUID HAND SANITIZER WITH LIME EXTRACT (CITRUS AURANTIFOLIA) AND ALOE VERA (ALOE VERA) AGAINST ESCHERICHIA COLI BACTERIA
Authors: Jayadi Lukky , Kesuma Sandry
Published: July 2022

One of the ways to prevent the spread of disease is to clean your hands using a hand sanitizer. Hand sanitizers are currently sterile hand sanitizers, usually as an alternative to washing the skin surface with a cleanser and air. Washing hands and skin with hand sanitizer is an action to maintain hand and skin hygiene to avoid infection that causes microbes, for example Escherichia coli microorganisms. The purpose behind this examination is make liquid hand sanitizer preparations with lime (Citrus aurantifolia) and aloe vera (Aloe vera) extracts that can kill Escherichia coli bacteria. In this study, the pH of the preparation was measured, the pH was 5 and for determining the specific gravity, the specific gravity was 0.9736 g/ml. The test is carried out using the percentage kill method at two contact times, namely 30 and 60 seconds. The percentage kill results for liquid hand sanitizer with lime (Citrus aurantifolia) and aloe vera (Aloe vera) extracts at the two contact times, with a percentage kill value of 99.9%. There is an impact using hand sanitizer with alcohol as an active ingredient with active alcohol ingredients with the addition of lime extract (Citrus aurantifolia) and aloe vera (Aloe vera) on pH, specific gravity and germicidal power.
THE EFFECT OF HPMC AS A GEL BASE AND TWEEN 80 SPAN 80 COMBINATIONS AS EMULGATORS IN ACETOSAL TRANSDERMAL EMULGEL PREPARATIONS
Authors: Rusli Nirwati , Setiawan Muhammad Azdar , Hikmawati Nur
Published: July 2022

Acetosal or acetyl salicylic acid is a drug that has efficacy as ananalgesic,antipireic, and antiplatelet. Aacetosal undegoes cross-first metabolisism (first passeffect) causing low drug bioavailability. The smal lsolubility of acetosal will affectthe rate of absorption which later affect the intensity of treatment, so transdermaldelivery in emulgel dosage forms can be one of. In this study an experimentalmethod was used by formulating an acetosal transdermal emulgel preparation, asa gel base HPMC was used at a concentration of 4%, 4.5%, 5% also variation oftween 80 concentration 6%, 5%, 4% and variation of Span 80 concentration 4%,5%, 6% as an emulgator. Then a physical evaluation of the preparation wascarried out which included organoleptic tests, pH tests, homogeneity tests,emulsion type tests, viscosity tests, spreadability tests and irritation tests. Theresults of the study showed that the formula 1 emulgel was bone white whileformulas 2 and 3 were white, the pH of the preparation ranged from 4.83-5.57,the preparation was homogeneous with an O/A emulsion type, the viscosity valueof the preparation ranged from 126.67-290 cPa. s, the dispersion value rangedfrom 5.20-6.30 and the preparation was not irritating.
CYTOTOXIC ACTIVITY OF KASUMBA FLOWER ETHANOL EXTRACT TURATE (Carthamus tinctorius Linn.) AGAINST THE LINE OF CANCER CELLS T47D BREASTS
Authors: Malik Fadhliyah , Malaka Muhammad Hajrul , Fristiohady Adryan , Wahyuni Wahyuni , Hamsid Rini , Sahidin Sahidin , Gani Annisa Fatinah
Published: July 2022

Breast cancer is a type of cancer with a high prevalence in the world and causes death in women. Chemotherapy is one type of treatment that is widely used. However, the problems of chemotherapy drugs such as side effects, drug resistance and inadequate efficacy. So, to overcome these problems, many natural ingredients have been explored to find anticancer agents that are expected to have good efficacy with minor side effects. Kasumba turate flowers (Carthamus tinctorius Linn.) is a plant from the Asteraceae tribe which is known to contain secondary metabolites with pharmacological activity as anticancer. This study aims to determine the types of secondary metabolites and the cytotoxic activity of the ethanolic extract of Kasumba turate flower against the T47D breast cancer cell line using the MTT assay method. Kasumba turate flower extract was obtained by maceration using 96% ethanol solvent, so that a concentrated extract with a weight of 107.8 grams was obtained with a yield value of 10.81%. The extract obtained was then subjected to a phytochemical screening test using the tube method and the results are alkaloids, flavonoids, tannins, and terpenoids. In the cytotoxic activity test, the test samples were varied into 7 concentration series, namely 10, 50, 100, 200, 400, 800 and 1000 ppm. The positive control used was 5-Fu. Cytotoxic parameter (IC50 value) was determined using GraphPad Prism and obtained IC50 5-Fu value of 65.88 ppm with active category while IC50 of the test sample was 157.3 with moderately active category as anticancer breast.
IN VITRO CYTOTOXICITY ASSAY OF Petrosia sp. ETHANOL EXTRACT BY USING MTT METHOD OF T47D BREAST CANCER CELL LINE
Authors: Pascayantri Asniar , Ningsih Mini Bekti , Sadarun Baru , Malaka Muhammad Hajrul , Fristiohady Adryan , Malik Fadhliyah , Sahidin I
Published: July 2022

Breast cancer is increasing as the constraints of side effects, drug-resistant, and high medical costs. Indonesia has a variety of marine biotas that can be explored. The sponge is one of the marines biotas that had potential candidates for anticancer compounds. The secondary metabolites of sponge such as steroids, alkaloids, polyketides, terpenoids, and polyacetylenes have pharmacology effects as anti-inflammation, antineoplastic and cytotoxic activity. The study is aimed to determine the secondary metabolite of Petrosian sp. ethanol extract and the cytotoxic activity at the T47D cell line of breast cancer. The ethanol extract of Petrosian sp. is obtained by maceration using 96% ethanol as a solvent. Extract weight is obtained 274.7 grams with a 2.94% yield of values. Cytotoxicity assay was using MTT methods with IC50 parameters by using software GraphPad prism version 5. Secondary metabolites of Petrosian sp. ethanol extract showing alkaloids, flavonoids, steroids, tannins, and saponins. The possible compound that showed anticancer activity is spinasterol. Cytotoxicity activities of Petrosian sp. ethanol extracts showing IC50 values at 78.13 ppm and IC50 values at 65.88 ppm on positive control. These results proved cytotoxicity activities had moderate cytotoxicity.
Studies on Nearctic species of Leucopis (Diptera: Chamaemyiidae). II. New species
Authors: Tanasijtshuk V.N.
Published: July 2022

Fifteen new Nearctic species of Leucopis (Diptera, Chamaemyiidae) are described: L. canthogena sp. n., L. rotundogena sp. n., L. ankophalla sp. n., L. saliceti sp. n., L. schlingeri sp. n., L. velutinifrons sp. n., L. dislineata sp. n., L. philoisos sp. n., L. aglaia sp. n., L. charactophalla sp. n., L. askophalla sp. n., L. lotophila sp. n., L. shannoni sp. n., L. chillcotti sp. n., and L. hermanni sp. n.
Evaluation of Open Science for co-creation of Social Innovations: A conceptual framework
Authors:   Kaunas University of Technology, Maciuliene Monika
Published: July 2022

Open Science is a rapidly expanding and diversifying field of social innovation with significant implications for and potential benefits to society, policy and various academic research areas. However, much is still unknown about the co-creation processes in Open Science and an overall conceptual framework which aids such understanding is missing. The article aims to address these limitations and identify the key dimensions of an ecosystem allowing co-creation in Open Science to unfold its social and economic impact. The research presented integrates the literature analysis on co-creation in multi-stakeholder ecosystems and suggest that three important dimensions have to be considered in evaluation of Open Science ecosystems: framework conditions, system conditions and outcomes. The proposed model was applied in qualitative analysis of thirty-three Open Science case studies. Based on the results of evaluation, it can be concluded that Open Science landscape is highly heterogenous, fragmented and not fully coordinated. The fragmentation appeared in all dimensions of evaluation. The outcomes of the research provide a first exploratory step in proposing innovative measures to determine the elements of co-creation practices within Open Science context.
Analysis and Countermeasures of Wormhole and Sinkhole Attacks in WBAN
Authors:   QUEST Nawabshah, Pakistan, Kanwal Aisha , Kumar Pardeep , Kumar Pardeep ,   QUEST Nawabshah, Pakistan, Asif Raheela ,   NED University of Engineering and Technology Karachi, Pakistan
Published: July 2022

Wireless Body Area Network (WBAN) is a promising technology that is having a significant number of applications in healthcare. Despite having several benefits, WBAN is susceptible to several security attacks, particularly related to the node misbehavior attacks such as sinkhole, wormhole, blackhole, and grayhole attacks. In this research work, the performance of the AODV protocol against wormhole and sinkhole attacks has been analyzed. This comparison-based study has been achieved for the PDR (Packet Delivery Ratio), NRL (Normalized Routing Load), residual energy, packet loss, average throughput, and average end-to-end delay metrics for WBAN with 20 and 50 nodes respectively. The results show that in 20 nodes network the PDR and average throughput of the sinkhole is 32% and 53% more than the wormhole attack, respectively. However, NRL is 36% and the average e2e delay is 63% less than the wormhole attack. In 50 nodes network, the PDR of a sinkhole attack is 26% and the average throughput is 10.7% more than the wormhole attack. Though, NRL and average e2e delays are 41.7% and 78.5% less than the wormhole attack, respectively. Hence, the wormhole attack in either network is more destructive than the sinkhole attack. Based on the simulation results, some solutions against the mentioned attacks have been recommended.
Self-Sustainable Non-Toxic Locust Control Using Electric Field & Real-Time Remote Monitoring Using Android Application
Authors:   Bahria University Karachi Pakistan, Ali Basit , Khalid Hadid ,   Anchor Development and Construction Company Bin Qasim Town Karachi, Pakistan, Rao Mushahid ,   nchor Development and Construction Company Bin Qasim Town Karachi, Pakistan
Published: July 2022

This paper presents a solution to overcome the locust attack issue on crops. Locusts and grasshoppers are among the most hazardous farming nuisances. Pesticides can harm non-target species and dirty the climate. Locusts are known to reproduce quickly and are capable of eating food of their own body weight on a daily basis. These hungry insects can eat the same amount of food that 35,000 human beings would be capable of eating. This setup will control the locust swarm by having a nontoxic solution. The setup consists of high voltage capacitor-based fencing that is used to spread an electric field that kills the locust sufficiently, ultraviolet light is also attached to attract the locust on a single point, and controlling and checking framework has been done using an android application. Different sensors are installed to measure the real-time data from the field location. The setup is solar-powered completely which makes it standalone and self-sustainable. An android application is also developed to operate and monitor the setup remotely.
Concordance of functional MRI memory task and resting-state functional MRI connectivity used in surgical planning for pediatric temporal lobe epilepsy
Authors: Tran Diem Kieu , Poliakov Andrew V. , Friedman Seth D. , Goldstein Hannah E. , Shurtleff Hillary A. , Bowen Katherine , Patrick Kristina E. , Warner Molly , Novotny Edward J. , Ojemann Jeffrey G. , Hauptman Jason S.
Published: July 2022

OBJECTIVE

Assessing memory is often critical in surgical evaluation, although difficult to assess in young children and in patients with variable task abilities. While obtaining interpretable data from task-based functional MRI (fMRI) measures is common in compliant and awake patients, it is not known whether functional connectivity MRI (fcMRI) data show equivalent results. If this were the case, it would have substantial clinical and research generalizability. To evaluate this possibility, the authors evaluated the concordance between fMRI and fcMRI data collected in a presurgical epilepsy cohort.

METHODS

Task-based fMRI data for autobiographical memory tasks and resting-state fcMRI data were collected in patients with epilepsy evaluated at Seattle Children’s Hospital between 2010 and 2017. To assess memory-related activation and laterality, signal change in task-based measures was computed as a percentage of the average blood oxygen level–dependent signal over the defined regions of interest. An fcMRI data analysis was performed using 1000 Functional Connectomes Project scripts based on Analysis of Functional NeuroImages and FSL (Functional Magnetic Resonance Imaging of the Brain Software Library) software packages. Lateralization indices (LIs) were estimated for activation and connectivity measures. The concordance between these two measures was evaluated using correlation and regression analysis.

RESULTS

In this epilepsy cohort studied, the authors observed concordance between fMRI activation and fcMRI connectivity, with an LI regression coefficient of 0.470 (R2 = 0.221, p = 0.00076).

CONCLUSIONS

Previously published studies have demonstrated fMRI and fcMRI overlap between measures of vision, attention, and language. In the authors’ clinical sample, task-based measures of memory and analogous resting-state mapping were similarly linked in pattern and strength. These results support the use of fcMRI methods as a proxy for task-based memory performance in presurgical patients, perhaps including those who are more limited in their behavioral compliance. Future investigations to extend these results will be helpful to explore how the magnitudes of effect are associated with neuropsychological performance and postsurgical behavioral changes.
Endoscopic third ventriculostomy in previously shunt-treated patients
Authors: Rocque Brandon G. , Jensen Hailey , Reeder Ron W. , Kulkarni Abhaya V. , Pollack Ian F. , Wellons John C. , Naftel Robert P. , Jackson Eric M. , Whitehead William E. , Pindrik Jonathan A. , Limbrick David D. , McDonald Patrick J. , Tamber Mandeep S. , Hankinson Todd C. , Hauptman Jason S. , Krieger Mark D. , Chu Jason , Simon Tamara D. , Riva-Cambrin Jay , Kestle John R. W. , Rozzelle Curtis J. , _ _
Published: July 2022

OBJECTIVE

Endoscopic third ventriculostomy (ETV) is an option for treatment of hydrocephalus, including for patients who have a history of previous treatment with CSF shunt insertion. The purpose of this study was to report the success of postshunt ETV by using data from a multicenter prospective registry.

METHODS

Prospectively collected data in the Hydrocephalus Clinical Research Network (HCRN) Core Data Project (i.e., HCRN Registry) were reviewed. Children who underwent ETV between 2008 and 2019 and had a history of previous treatment with a CSF shunt were included. A Kaplan-Meier survival curve was created for the primary outcome: time from postshunt ETV to subsequent CSF shunt placement or revision. Univariable Cox proportional hazards models were created to evaluate for an association between clinical and demographic variables and subsequent shunt surgery. Postshunt ETV complications were also identified and categorized.

RESULTS

A total of 203 children were included: 57% male and 43% female; 74% White, 23% Black, and 4% other race. The most common hydrocephalus etiologies were postintraventricular hemorrhage secondary to prematurity (56, 28%) and aqueductal stenosis (42, 21%). The ETV Success Score ranged from 10 to 80. The median patient age was 4.1 years. The overall success of postshunt ETV at 6 months was 41%. Only the surgeon’s report of a clear view of the basilar artery was associated with a lower likelihood of postshunt ETV failure (HR 0.43, 95% CI 0.23–0.82, p = 0.009). None of the following variables were associated with postshunt ETV success: age at the time of postshunt ETV, etiology of hydrocephalus, sex, race, ventricle size, number of previous shunt operations, ETV performed at time of shunt infection, and use of external ventricular drainage. Overall, complications were reported in 22% of patients, with CSF leak (8.6%) being the most common complication.

CONCLUSIONS

Postshunt ETV was successful in treating hydrocephalus, without subsequent need for a CSF shunt, in 41% of patients, with a clear view of the basilar artery being the only variable significantly associated with success. Complications occurred in 22% of patients. ETV is an option for treatment of hydrocephalus in children who have previously undergone shunt placement, but with a lower than expected likelihood of success.
ЕКСПЕРИМЕНТАЛЬНІ ДОСЛІДЖЕННЯ НАПРУЖЕНО-ДЕФОРМОВАНОГО СТАНУ ЗАЛІЗОБЕТОННИХ АРОК З ВИСОКОМІЦНОГО БЕТОНУ
Authors: Караван Богдан
Published: July 2022

Наразі при зведені будівель і споруд розширюється використання залізобетонних арок, зокрема для споруд фортифікаційного призначення та для будівель цивільного захисту. Особливо привертають увагу арки, які виготовляються з високоміцного бетону, що сприяє зменшенню ваги конструкцій та навантажень на інші конструктивні елементи будівель, фундаменти та основи. Але дослідження особливостей роботи таких арок під навантаженням на сьогодні практично відсутні. В статті наводяться результати експериментальних досліджень моделей арок, виготовлених з високоміцного бетону.
ПРОСТОРОВІ РІВНЯННЯ СТІЙКОСТІ АНІЗОТРОПНИХ ТОВСТИХ ЦИЛІНДРИЧНИХ ОБОЛОНОК ПІД ДІЄЮ ОСЬОВОГО ТИСКУ
Authors: Трач Володимир , Подворний Андрій
Published: July 2022

Спираючись на модифікований варіаційний принцип Ху-Васідзу, в роботі, отримана лінеаризована тривимірна система звичайних однорідних диференціальних рівнянь стійкості в частинних похідних теорії пружності анізотропного пустотілого тіла в циліндричній системі координат. На її основі приведений підхід для знаходження величин критичних напружень анізотропної товстостінної композитної циліндричної оболонки, що знаходиться під дією осьового тиску
НЕТРАДИЦІЙНЕ АРМУВАННЯ В ОДНОРІДНИХ ПРОЛІТНИХ ЕЛЕМЕНТАХ З НІЗДРЮВАТИХ БЕТОНІВ
Authors: Фамуляк Юрій , Демчина Богдан
Published: July 2022

Ніздрюваті бетони належать до крихких матеріалів, які без додаткового армування неможливо використовувати як пролітні конструкції. Наявні дослідження та розробки стосуються переважно традиційного армування сталевою стрижневою арматурою, яка за рахунок своєї високої міцності використовується лише на 10-20%. Використання нетрадиційного армування дозволяє більш повно використати запас міцності матеріалу такого армування.
ПОРІВНЯЛЬНИЙ АНАЛІЗ ДОСЛІДЖЕНЬ ЗЧЕПЛЕННЯ АРМАТУРИ З БЕТОНОМ РІЗНИМИ МЕТОДАМИ ВИПРОБУВАННЯ
Authors: Філіпчук Сергій , Поляновська О.Є.
Published: July 2022

Проведений аналіз досліджень зчеплення арматури з бетоном як звичайної міцності так і високоміцних бетонів дає змогу говорити про достовірність як математичного моделювання так і отриманих експериментальних даних. Міцність бетону суттєво впливає на метод визначення напружень зчеплення і збільшується зі збільшенням класу бетону.
ОСОБЛИВОСТІ РОБОТИ БУРОІН’ЄКЦІЙНИХ ПАЛЬ В НЕСТІЙКОМУ ВОДОНАСИЧЕНОМУ ҐРУНТІ
Authors: Алексієвець Валентин , Алексієвець Іван , Іванюк Андрій
Published: July 2022

Наведено результати розрахунку, проектування та застосування буроін’єкційних паль в нестійких водонасичених ґрунтах на прикладі об’єкту проектування та реконструкції стадіону «Авангард» в м. Рівне. Виконані статичні випробування буроін’єкційних паль та підтверджено збільшення значень фактичної несучої здатності паль відносно розрахункової.
ДО ПРОБЛЕМИ ОЦІНКИ ЗАЛИШКОВОГО РЕСУРСУ ЗАЛІЗОБЕТОННИХ КОНСТРУКЦІЙ, ЩО ЗНАХОДЯТЬСЯ В ЕКСПЛУАТАЦІЇ
Authors: Титаренко Роман , Хміль Роман
Published: July 2022

У розрізі аналізу сучасних досліджень розглянуто актуальну проблему оцінки довговічності (залишкового ресурсу) залізобетонних конструкцій, що знаходяться в експлуатації. Сформульовані проблеми розрахунково-нормативної бази, переваги і недоліки існуючих моделей такої оцінки, а також рекомендації щодо майбутніх досліджень.
The turnover intention among IT professionals: A person-organisation fit, person-job fit, and HRM perspective
Authors: Kakar Abdul Samad , Muhammad Khan Nida , Haider Aftab
Published: July 2022

OBJECTIVE: Turnover of IT professionals has become a pressing problem for the management of Banks. To date, limited research has examined the role of human resource management practices (HRMP), person-organisation fit (POF), and person-job fit (PJF) in retaining IT professionals. This study provides an empirical analysis of the direct and indirect effect of HRMP on IT professionals’ turnover intention through POF and PJF. METHODS: The quantitative data collected from 292 IT professionals were analysed through PLS-SEM. RESULTS: The findings revealed a negative and significant relationship between HRMP and employees’ turnover intention. It was further revealed that HRMP relates positively to POF fit and PJF, whereas POF and PJF relate negatively to employees’ turnover intention. Moreover, the findings revealed that POF and PJF explain the intervening mechanism (mediation) between HRMP and turnover intention. CONCLUSIONS: This study shows that IT professionals’ turnover intention is affected by their perceptions of HRMP, POF, and PJF. The study has further extended our understanding of the mediating mechanism involved between HRMP and turnover intention. This study suggests that organisations need to implement HRMP that not only enhances IT professionals’ knowledge, skills, and abilities but also strengthens their congruence with the values and goals of the organisations.
Antihypertensive Medication Class and the Risk of Dementia and Cognitive Decline in Older Adults: A Secondary Analysis of the Prospective HELIAD Cohort
Authors: Liampas Ioannis , Hatzimanolis Alex , Siokas Vasileios , Yannakoulia Mary , Kosmidis Mary H. , Sakka Paraskevi , Hadjigeorgiou Georgios M. , Scarmeas Nikolaos , Dardiotis Efthimios
Published: July 2022

Background: It is unclear whether the main antihypertensive medication classes (diuretics, calcium channel blockers, beta-blockers, angiotensin converting enzyme inhibitors, and angiotensin receptor blockers (ARBs)) are associated with different risks of cognitive decline. Published evidence is conflicting and stems mainly from observational studies. Objective: To investigate the differential effects of antihypertensives on the risks of developing dementia and cognitive decline, with a specific focus on the vascular component of the mechanisms underlying these interactions. Methods: Older adults with a history of hypertension and without dementia were drawn from the population-based HELIAD cohort. Age-, gender-, education-, and antihypertensive medication- (five dichotomous exposures) adjusted Cox proportional-hazards models and generalized estimating equations were performed to appraise the associations of baseline antihypertensive therapy with dementia incidence and cognitive decline (quantified using a comprehensive neuropsychological battery). Analyses were subsequently adjusted for clinical vascular risk (dyslipidemia, diabetes mellitus, smoking, cardiovascular, and cerebrovascular history) and genetic susceptibility to stroke (using polygenic risk scores generated according to the MEGASTROKE consortium GWAS findings). Results: A total of 776 predominantly female participants (73.61±4.94 years) with hypertension and a mean follow-up of 3.02±0.82 years were analyzed. Baseline treatment was not associated with the risk of incident dementia. ARB users experienced a slower yearly global cognitive [2.5% of a SD, 95% CI = (0.1, 4.9)] and language [4.4% of a SD, 95% CI = (1.4, 7.4)] decline compared to non-users. The fully adjusted model reproduced similar associations for both global cognitive [β= 0.027, 95% CI =  (–0.003, 0.057)], and language decline [β= 0.063, 95% CI = (0.023, 0.104)]. Conclusion: ARBs may be superior to other antihypertensive agents in the preservation of cognition, an association probably mediated by vascular-independent mechanisms.
Disparities in Clinical Care and Research in Renal Cell Carcinoma
Authors: Pain Debanjan , Takvorian Samuel U. , Narayan Vivek
Published: July 2022

Disparities in cancer screening, prevention, therapy, clinical outcomes, and research are increasingly recognized and pervade all malignancies. In response, several cancer research and clinical care organizations have issued policy statements to acknowledge and address barriers to achieving health equity in cancer care. The increasingly specialized nature of oncology warrants a disease-focused appraisal of existing disparities and potential solutions. Although clear improvements in clinical outcomes have been recently observed for patients with renal cell carcinoma (RCC), these improvements have not been equally shared across diverse populations. This review describes existing RCC cancer disparities and their potential contributing factors and discusses opportunities to improve health equity in clinical research for all patients with RCC.
Use of unmanned aerial vehicles to monitor the performance of work on scattered construction sites and ways to further implement them in construction in Ukraine
Authors: Zeltser R. , Kolot M. , Panasyuk I.
Published: July 2022

The article covers the improvement of organizational and technological solutions of construction production through the use of unmanned aerial vehicles and special software for remote control of construction of scattered facilities (for example, the construction of cottages in Kyiv region), the experience of using UAVs.

Innovative approaches to the control of the life cycle of construction projects at the stages of engineering surveys and design works, zero cycle, construction of the above-ground part and further operation using drones and special software give the Ukraine construction sector companies a unique chance to realize their potential during the digital revolution and take their rightful place among world leaders.

Due to the lack of operational, accurate data and indicators that describe the state of the construction site, companies face such problems as management’s lack of up-to-date information on the project implementation progress, late detection of actual of the progress of work performed from design documentation, uncontrolled human factor in the process of checking volumes and quality of works performed by contractors, insufficient communication between project participants. Subsequently, these factors lead to budget overruns and non-compliance with the estimated project deadlines.

The experience of using UAVs in addressing such issues as the management’s lack of relevant information on state of affairs at construction site, late identification of actual deviations from the project documentation, uncontrolled influence of human factor in the process of checking the volume and quality of work performed by contractors, and insufficient communication between project participants.

Based on the practical experience gained in the use of drones, it was concluded that drones are an effective tool with a wide range of applications for monitoring zero-cycle work and erection of the above-ground part of buildings.
Pengaruh Pasar Online Terhadap Pendapatan Usaha Mikro Pada Masa Pandemi Covid-19 Di Jombang
Authors: Nurwidyanti Mike , Mohamad Sofwan
Published: July 2022

Dewasa ini peran teknologi komunikasi dalam hal ini internet bukan hanya berfungsi sebagai sarana mencari informasi tapi juga sebagai media untuk memasarkan produk dan melakukan perdagangan. Bagi usaha mikro media online seperti facebook, instagram, twitter, whatsapp dan lainnya sangat membantu dalam memperkenalkan produk, memasarkan sekaligus berinteraksi dengan konsumen. Selain itu dengan melakukan transaksi secara online, banyak sekali biaya operasional yang bisa dihemat. Metode penelitian yang dilakukan adalah deskriptif dengan melakukan kajian literature dan mencatat fakta yang terjadi di lapangan. Dalam situasi pandemic Covid-19 seperti saat ini, banyak sekali kegiatan kehidupan yang harus dibatasi demi mencegah penularan virus yang semakin meluas. Termasuk kegiatan jual beli atau perdagangan. Banyak agenda bazar offline produk usaha mikro terpaksa ditiadakan dengan adanya wabah ini. Sehingga ini berpengaruh terhadap pendapatan  usaha mikro. Pasar online adalah salah satu solusi yang bisa dilakukan untuk tetap mendapatkan penghasilan meski terbatas ruang dan gerak. Berdasarkan data survey responden, diketahui bahwa selam mengikuti pasar online terjadi peningkatan pendapatan sebesar 32%. Sistem pre order yang diberlakukan pada pasar online juga membantu usaha mikro untuk mengurangi resiko barang tidak laku. Karena banyak usaha mikro yang masih terbatas permodalan, sehingga penyediaan produk di pasar online sesuai dengan order yang sudah dicatat oleh koordinator.pasar online terbukti efektif menmberikan peluang pendapatan dan promosi bagi banyak pengusaha mikro di Jombang.
PENDAMPINGAN BELAJAR SISWA SD DI KELURAHAN MEKARJAYA, KECAMATAN RANCASARI, KOTA BANDUNG SELAMA PANDEMI COVID-19 SEBAGAI BENTUK PENGABDIAN MAHASISWA
Authors: Purwanto Putri Alifia Ayu , Dadiono Muh. Sulaiman
Published: July 2022

Pengabdian mahasiswa bertujuan untuk membantu menyelesaikan permasalahan warga yang terdampak Covid-19 di lingkungan KKN Kelurahan Mekarjaya, Kecamatan Rancasari, Kota Bandung khususnya bidang Pendidikan dengan melakukan pendampingan belajar siswa Sekolah Dasar. Metode yang digunakan adalah dengan metode survey, wawancara dan pendampingan langsung. Metode survey dilakukan untuk mengamati situasi dan keadaan masyarakat dalam hal ini mengamati keadaan siswa SD yang sedang melaksanaan pembelajaran. Metode wawancara ditekankan untuk mengambil informasi dan data secara langsung. Metode pendampingan langsung digunakan untuk menyelesaikan permasalahan masyarakat di bidang pendidikan akibat pandemi Covid-19. Hasil dari kegiatan pendampingan belajar siswa SD oleh mahasiswa terbukti dapat meningkatkan semangat belajar siswa SD di Kelurahan Mekarjaya, Kecamatan Rancasari, Kota Bandung dilihat dari respon yang baik dari siswa SD yang terbantu dalam belajar dan mengerjakan tugas sekolah selama pandemi Covid-19.

 
World Agro-Food Markets and the Participation of Ukraine in Them
Authors:   Central Ukrainian National Technical University, Reshytko Tetyana
Published: July 2022

The article examines the development trends on the world markets of agro-food products. It is pointed out that the world food market is developing according to the trends of international economic relations, so it mainly reflects their characteristic patterns in a certain period of time. The intensification of globalization and international integration has led to changes in the economies of certain countries and the whole world, as well as it has changed the consumer preferences and tastes of people around the world, so the development of agro-food markets is extremely important. The countries that form the main demand for agro-food products and comprise the main driving force of world trade in world markets are named. Regularities between the economic development of the country and consumer preferences are revealed. Forecasts on the expected state of the world food market are given and the place of Ukraine in these processes is determined. It is investigated that in the future the presence of our state on world grain markets will be maintained. It is indicated on the segment of Ukraine in the world trade of agricultural goods. It is emphasized that Ukraine is currently only at the initial stage of entering the world agro-food markets, and domestic food exports are dominated by raw materials or products with low added value (grain, vegetable oil, sugar, etc.), and exports of final food products have not reached significant volumes. The supply of ready-made domestic food products to the world market should become one of the important landmarks of the country's foreign economic policy.
Problems of Development of Innovative Business Processes at the Enterprises of the Hotel Industry
Authors:   Mykhailo Ostrohradskyi National University, Trunina Iryna , Bilyk Maryna ,   Mykhailo Ostrohradskyi National University, Chorna Maria ,   Mykhailo Ostrohradskyi National University
Published: July 2022

It is substantiated that the problems of development of innovative business processes at the enterprises of the hotel industry are due to the lack of qualified personnel. The COVID-19 pandemic has led to a crisis in the entire tourism industry and the hotel industry in particular. Under these conditions, mass layoffs and layoffs of specialists involved in innovative business processes of hotel enterprises began, which had a significant impact on the performance of many organizations. In crisis conditions, outsourcing is the solution to these problems. In today's economy, only those hotel companies that conduct their business as efficiently as possible function and achieve success. One of the most successful models for achieving maximum efficiency is outsourcing. Outsourcing is the transfer of non-core functions of the enterprise and all related assets to the management of a professional contractor. Outsourcing companies are constantly investing in innovative technologies and working to improve the methodology of a particular production process. Due to their narrow specialization and a large number of clients of the enterprise, outsourcers have extensive knowledge and vast experience in solving various kinds of problems and provide quality services. The article defines the features of outsourcing at the enterprises of the hotel industry, considers the main advantages and disadvantages of using the services of outsourcing companies. The main problems of using the services of outsourcing companies by hotel enterprises are identified. It is substantiated that for the hotel business of Ukraine, which is characterized by problematic situations due to the COVID-19 pandemic (complete or partial closure of hotels and other accommodation facilities, reduction of staff, etc.), it is important to implement innovative business processes that will bring hotel companies to pre-crisis level of functioning. Personnel outsourcing is a promising area of innovation processes, so the study of its features in the hotel business (seasonality, use in major business processes), research of advantages and disadvantages, highlighting the main problems of use in Ukraine (small number of regional outsourcing companies, absence of the methodological framework for determining the effect of the use of this type of service, psychological barriers of managers and hotel staff) will allow to use the most effective methods of hotel business management in overcoming the crisis. Prospects for further research based on the study of international experience are to assess the economic effect of the introduction of outsourcing companies in the hotel business.
Creative and Intellectual Component – A Driver of the Restaurant Business
Authors:   Kyiv National University of Technologies and Design, Yavorska Oksana
Published: July 2022

The article considers the current state and role of the creative and intellectual component of the restaurant industry in overcoming the crisis of the service sector in a pandemic and the spread of Covid-19 and the specifics of the restaurant industry in Ukraine in the pandemic and opportunities in accordance with existing corporate assets. The aim of the study was to conduct an analytical review of the state and prospects of the restaurant industry in the country and develop recommendations for the use of internal corporate resources and assets of the restaurant sector in the Covid-19 pandemic. We have used a set of general and special methods in this article (they are historical and logical method, method of analysis and synthesis, diagram method, scientific abstraction). We reviewed the literature and used some staffing interpretations. The carried-out analysis of creative and intellectual capital of the enterprises of the restaurant industry taking into account specifics of the have been used to support existing managerial policies for better retention practices and management of resources, for better management practices of the enterprises. It is established that after the deep crisis of 2020, there is a gradual increase in the volume of services provided to the population by catering establishments. It is proposed at the initial stage of recovery of the restaurant industry to emphasize the importance of increasing intra-corporate resources of food establishments. The results of our study prove the fact that in the period of reformatting the business strategies of restaurants and increasing the adaptability of food establishments during the pandemic, as well as in the future, human resources and intellectual assets will form the dominant entrepreneurial success and the creative space of restaurants. It is determined that the creative and intellectual assets of the restaurant industry are activators of the development of this sector of services, as well as the space for the formation of innovative forms of organization of food establishments.
PENGARUH EARNING PER SHARE DAN PRICE EARNING RATIO TERHADAP RETURN SAHAM
Authors: Borolla Johanis Darwin , Pelmelay Krisaldya Ester
Published: July 2022

This study aims to find out the effect of Earnings Per Share (EPS) and Price Earnings Ratio (PER) toward company stock returns in cosmetic and household needs sub-sector that registered at Indonesia Stock Exchange. The study period is from 2015 to 2019. Six samples were obtained through the purposive sampling technique during the research period from 2015 to 2019. The data of this study were analyzed by using multiple linear regression with the SPSS program. The results of this study indicates that EPS has a positive and significant effect on stock returns meanwhile PER does not have any significant effect on stock returns.
The Use of Epistemic Modality Markers as Hedges in Scientific Research Texts
Authors: KORKMAZ Hüsem
Published: July 2022

Bilgisel kiplik bir ifadede sunulan bilgiye ilişkin yazarın özgüven düzeyini yansıtır. Yazarın sözcük seçimlerinin bilginin artarımında önemli rol oynadığı bilimsel araştırmalar, pekiştirici veya önermenin kesinliğini azaltan ifadeler olarak kiplik belirticilerinin dikkatle seçimini gerektirir. Bu bağlamda, mevcut çalışma Türk araştırmacıların doktora tezleri, yüksek lisans tezleri ve araştırma makaleleri gibi akademik metinlerde bilgisel kiplik belirticilerini önermenin kesinliğini azaltan ifadeler olarak kullanımını incelemeyi amaçlamaktadır. Bu bütünce çalışmasında, İngiliz Dilbilimi, İngilizce Öğretmenliği ve İngiliz Dili ve Edebiyatı alanlarında yayınlanmış olan 30 akademik yayının (10 doktora tezi, 10 yüksek lisans tezi ve 10 araştırma makalesi) giriş ve sonuç kısımlarından oluşan iki bütünce araştırma sorularını cevaplamak amacıyla veri olarak kullanılmıştır.Verilerin bütünce analizi, "may" ve "can" kiplik fiillerinin yayınların giriş kısımlarında sıklıkla kullanıldığını ortaya koymuştur ki bu da yazarların yayınların sonuç kısımlarında daha az tereddütlü iken giriş bölümlerinde daha fazla tereddüt taşıdıklarını göstermektedir. Bunun yanında, Türk araştırmacıların kiplik fiilerini diğer bilgisel kiplik belirticilerine kıyasla daha sık kullandıkları sonucuna varılmıştır.
Meta-Thematic Analysis of the Studies on the Remedial Education Program in Primary Schools
Authors: Kinay İsmail , Hamidi Necmeddin Berk
Published: July 2022

The purpose of this research is to analyze the studies on the Remedial Education Program in Primary Schools using meta-thematic analysis. In this research, qualitative research papers containing the opinions of participants about the Remedial Education Program in Primary Schools (REPPS) were examined by reviewing using Google Scholar and TR Dizin databases. In our research, research papers were determined by making a search using the keywords “Remedial Education Program in Primary Schools” and “REPPS.” As a result of the review, 12 articles published as full text, using the qualitative research model and containing participant views, were included in the research. Five themes were developed as a result of this research.
Morti infantili, morti fetali e cause necrologi condivise: implicazioni e una nuova prospettiva analitica sulla mortalità infantile
Authors: Ramalho Junior Alvaro
Published: July 2022

Nel biennio 2018/2019, è stato riscontrato che circa il 64% dei decessi infantili nello Stato di Espírito Santo, in Brasile, deriva da cause necrologi comuni alle morti fetali, qualificando come eventi tipici che si escludono a vicenda, in cui il verificarsi di uno dei esse esclude sintomaticamente il verificarsi dell’altro per la stessa causa necrologi, stabilendo così un rapporto inesorabile di esclusione dell’interdipendenza, associando inversamente le occorrenze tra di loro. Sollevare la domanda sulle implicazioni di tale rapporto nella prospettiva analitica del fenomeno della mortalità infantile, questione che è diventata il filo conduttore nello svolgimento di questo lavoro. Da cui ha formulato l’obiettivo di analizzare questo rapporto al fine di svelare la complessità del fenomeno della mortalità infantile, portando alla luce nuovi elementi fino ad allora sconosciuti. In questo senso, come base metodologica per l’analisi empirica, incentrata sullo Stato dell’Espírito Santo, ha formulato un modello teorico/concettuale che consente l’analisi simultanea dei due eventi, considerandoli concettualmente differenziati, tuttavia correlati, dimostrando empiricamente l’esistenza di una dinamica ciclica intrinseca al fenomeno, sostenuta da forze endogene originate dalla relazione di interdipendenza escludente, risultanti dalla condivisione di cause necrologi tra morte neonatale e fetale. Pertanto, in risposta alla domanda guida, si è concluso che fosse urgente ripensare l’analisi della mortalità infantile, rompendo la tradizione ristretta alla sola morte dei bambini di età compresa tra 0 e 1 anno, a rischio di errori grossolani nella interpretazione della realtà. Secondo l’obiettivo delineato, ha analizzato l’interazione tra questa dinamica endogena e le forze esogene provenienti da fattori strutturali restrittivi (povertà, servizi igienico-sanitari, ecc.), rivelando nuovi elementi inerenti alla complessità del fenomeno, come, ad esempio, sull’azione ibrida di fattori esogeni ed endogeni nel determinare i tassi di mortalità infantile, tra gli altri. Infine, legando insieme i vari punti discussi, questo lavoro dimostra la validità della tesi che individua nell’interazione tra morti fetali e morti infantili per cause comuni necrologi, l’origine di forze endogene autonome, a supporto di una dinamica ciclica endogena, attraverso la quale si irradia i suoi effetti nocivi in ​​tutto l’universo della mortalità infantile, alterando sistematicamente gli scenari della realtà.
Décès infantiles, morts fœtales et causes nécrologiques partagées : implications et nouvelle perspective analytique sur la mortalité infantile
Authors: Ramalho Junior Alvaro
Published: July 2022

Au cours de l’exercice biennal 2018/2019, il a été constaté qu’environ 64 % des décès de nourrissons dans l’État d’Espírito Santo, au Brésil, résultant de causes nécrologiques communes aux décès fœtaux, les qualifiant d’événements typiques mutuellement exclusifs, dans lesquels la survenue de l’un des exclut symptomatiquement l’occurrence de l’autre pour la même cause nécrologique, établissant ainsi une relation inexorable d’interdépendance excluante, associant inversement les occurrences entre elles. Se pose la question des implications de cette relation dans la perspective analytique du phénomène de la mortalité infantile, question qui est devenue le fil conducteur dans la conduite de ce travail. D’où il a formulé l’objectif d’analyser cette relation en vue de révéler la complexité du phénomène de la mortalité infantile, mettant en lumière de nouveaux éléments jusqu’alors inconnus. En ce sens, comme base méthodologique pour l’analyse empirique, centrée sur l’État d’Espírito Santo, il a formulé un modèle théorique/conceptuel permettant l’analyse simultanée des deux événements, les considérant conceptuellement différenciés, mais interdépendants, démontrant empiriquement l’existence d’une dynamique cyclique, intrinsèque au phénomène, entretenue par des forces endogènes issues de la relation d’interdépendance excluante, résultant du partage des causes nécrologiques entre décès infantile et fœtal. Ainsi, en réponse à la question directrice, il a été conclu qu’il était urgent de repenser l’analyse de la mortalité infantile, rompant avec la tradition restreinte aux seuls décès d’enfants âgés de 0 à 1 an, au risque d’erreurs grossières dans Interprétation de la réalité. Selon l’objectif défini, elle a analysé l’interaction entre cette dynamique endogène et les forces exogènes émanant de facteurs structurels contraignants (pauvreté, assainissement, etc.), faisant apparaître de nouveaux éléments inhérents à la complexité du phénomène, comme, par exemple, sur l’ action hybride de facteurs exogènes et endogènes dans la détermination des taux de mortalité infantile, entre autres. Enfin, en nouant les différents points abordés, ce travail démontre le bien-fondé de la thèse qui identifie dans l’interaction entre les morts fœtales et les morts infantiles de causes mortuaires communes, l’origine de forces endogènes autonomes, soutenant une dynamique cyclique endogène, à travers laquelle elle rayonne ses effets néfastes dans tout l’univers de la mortalité infantile, modifiant systématiquement les scénarios de la réalité.
Contribuição de jogos virtuais como estratégia na reabilitação de pacientes com Parkinson: uma revisão bibliográfica
Authors: Trindade Geneily Negreiros , Oliveira Rozania Cruz de , Lopes Alessandra Dourado da Costa , Kitzinger Karoline Pinheiro , Silva Vanessa Christina Costa da , Oliveira Ginarajadaça Ferreira dos Santos
Published: July 2022

A Doença de Parkinson (DP) é uma doença neurodegenerativa, crônica e progressiva, caracterizada pelos sinais cardinais de tremor em repouso, bradicinesia, rigidez e instabilidade postural, além de outras características. A fisioterapia por meio de jogos virtuais tem beneficiado pacientes neurológicos, e contribuído na reabilitação do controle motor e cognitivo de indivíduos com DP. Assim, a presente pesquisa norteia-se pela problemática: quais foram as contribuições dos jogos virtuais nos últimos 5 anos como estratégia de reabilitação em pacientes com Doença de Parkinson? Com base neste questionamento, o objetivo deste estudo foi investigar a contribuição de jogos virtuais na reabilitação de parkinsonianos e apresentar os benefícios dessa tecnologia como estratégia terapêutica. Para isso, foi realizada uma revisão bibliográfica, com pesquisas nos bancos de dados Scielo, Medline, PubMed, Biblioteca Virtual em Saúde e Periódicos. Foram incluídos artigos publicados a partir do ano de 2018 a abril de 2022, em língua portuguesa e inglesa. Foram utilizadas as seguintes palavras-chave: Parkinson, Realidade Virtual e Gameterapia. Após análise dos 24 artigos selecionados conforme os critérios de inclusão, pôde-se observar que a intervenção com realidade virtual contribuiu positivamente nas habilidades motoras, cognitivas, na motivação e qualidade de vida em pacientes com Doença de Parkinson.