bluuebunny/crossref_metadata_2025 huggingface dataset:
PERUBAHAN FONETIS BAHASA JAWA STANDAR DIALEK JEMBER
Authors: Fitriah Siti
Published: April 2024

Bahasa Jemberan atau bahasa Jawa dialek Jember merupakan bahasa Jawa yang memiliki kekhasan di antara dialek bahasa Jawa. Hal itu terjadi karena Jember merupakan salah satu tempat bertemunya dua etnis besar yang ada di Indonesia, yaitu suku Jawa dan suku Madura yang menghasilkan budaya baru yang dikenal dengan budaya pendalungan. Interaksi antaretnis memungkinkan terjadinya perubahan fonetis pada kosakata bahasa Jawa pada tuturan masyarakat Jember. Tujuan penelitian ini adalah untuk mendeskripsikan bentuk perubahan fonetis bahasa Jawa standar dialek Jember dan  penyebab perubahan tersebut terjadi. Metode yang digunakan adalah metode komparatif deskriptif yakni dengan mendeskripsikan perbandingan unsur fonetis yang ada di dalam bahasa Jawa standar dengan bahasa Jawa dialek Jember. Data dikumpulkan dengan menggunakan teknik refleksif-introspektif. Hasil analisis data menunjukkan bahwa terdapat lima fonem di dalam bahasa Jawa standar yang mengalami perubahan bunyi ketika dilafalkan  pada kosakata tertentu, yaitu fonem /o/, /i/, /u/, /w/, dan /p/. Penyebab perubahan fonetis tersebut diakibatkan oleh asimilasi fonemis, asimilasi bukan fonemis, dan kontraksi.
ANALISIS WACANA KRITIS MODEL TEUN A. VAN DIJK PADA NASKAH FILM PULAU PLASTIK
Authors: Astari Delima , Widayati Dwi , Siregar Asrul
Published: April 2024

Tujuan penelitian ini adalah untuk mengkaji unsur teks, kognisi sosial, dan konteks sosial pada naskah film Pulau Plastik. Penelitian ini dilakukan dengan  pendekatan analisis wacana kritis model van Dijk. Yang menjadi sumber data adalah nasakah film Pulau Plastik. Pengumpulan data yang dilakukan dengan teknik simak dan catat. Untuk menganalisis data digunakan metode agih berupa teknik dasar dan teknik lanjutan. Hasil penelitian ini sebagai berikut. Pertama, dari analisis struktur teks ditemukan tiga aspek, yaitu (1) pada struktur makro, tema film adalah bahaya penggunaan sampah plastik sekali pakai; (2) pada unsur superstruktur ditemukan  judul dan lead menampilkan situasi dan komentar yang saling berkaitan; (3) pada struktur mikro, dalam film terkandung elemen latar, detail, maksud, pranggapan, bentuk kalimat, kata ganti, preposisi, konjungsi, leksikon, gaya bahasa. Kedua, kognisi sosial yang dipresentasikan dalam film Pulau Plastik adalah keadaan pribadi para tokoh mengenai darurat sampah, penilaian orang terhadap peristiwa tersebut, serta bagaimana tokoh memahami peristiwa di sekitarnya. Ketiga, pada konteks sosial ditemukan bahwa praktik kekuasaan yang dilakukan pemerintah hanya memberi dukungan tanpa memberi solusi yang baik terhadap darurat sampah. Hasil penelitian ini dapat membuka mata terhadap peristiwa darurat sampah di Indonesia yang selama ini diacuhkan begitu saja.
IMPLEMENTASI MODEL PEMBELAJARAN BERBASIS PROYEK PADA PEMBELAJARAN TEKS PROSEDUR: STUDI KASUS DI KELAS VII SMP NEGERI 8 SURAKARTA
Authors: Sukmawati Nanda , Setiawan Budhi , Ulya Chafit
Published: April 2024

Penelitian ini bertujuan untuk memaparkan implementasi model pembelajaran berbasis proyek pada pembelajaran teks prosedur di kelas VII SMP Negeri 8 Surakarta. Penelitian ini menggunakan pendekatan deskriptif kualitatif. Sumber data yang digunakan adalah proses pembelajaran, informan guru mata pelajaran Bahasa Indonesia dan peserta didik kelas VII di SMP Negeri 8 Surakarta, dokumen terkait model pembelajaran berbasis proyek, serta catatan lapangan proses model pembelajaran berbasis proyek. Teknik pengambilan sampel yang digunakan adalah purposive sampling. Teknik pengumpulan data berupa observasi, wawancara, dan analisis dokumen. Hasil penelitian ini menunjukkan bahwa implementasi model pembelajaran berbasis proyek secara garis besar sudah sesuai dengan sintak model pembelajaran berbasis proyek yakni dilakukan melalui tahap perencanaan, pelaksanaan, dan pelaporan.
NILAI SOSIAL DAN FUNGSI SAGE KISAH SITI FATIMAH BINTI MAIMUN DI GRESIK DALAM KEHIDUPAN BERMASYARAKAT: TEORI FUNGSI BASCOM
Authors: Gita Tiara Ayu Berliana Ana
Published: April 2024

Seperti daerah lainnya, Gresik memiliki tradisi lisan yang hampir punah karena belum didokumentasikan sehingga tidak diketahui keberadaannya oleh masyarakat setempat, terutama generasi muda. Tujuan penelitian ini adalah untuk mempresentasikan nilai, fungsi, dan implementasi sage Siti Fatimah binti Maimun di Gresik yang masih bersifat tradisi lisan. Penelitian ini dilakukan dengan metode deskriptif kualitatif yang menganalisis cerita berupa sage Siti Fatiman dengan teoti fungsi Bascom. Yang informan kuncinya adalah warga lokal di Desa Leran yang memahami kisah Siti Fatimah dan pemilihannya dilakukan dengan purposive sampling dan snow ball sampling. Data dikumpulkan melalui wawancara mendalam yang validitasnya diuji melalui triangulasi metode dan triangulasi sumber. Analisis yang dilakukan berupa identifikasi data, klasifikasi data, tafsiran data, serta kesimpulan data. Hasil penelitian ini menunjukkan nilai sosial dalam sage Siti Fatimah binti Maimun terletak pada karakter positif yang dimiliki Nyai siti serta implementasi sikap dari Nyai Siti wajib diteladani oleh masyarakat karena mengandung banyak nilai moral, sosial, dan agama. Adapun fungsi sage Siti Fatimah adalah (1) sebagai alat hiburan karena kisahnya dapat dijadikan sebagai penarik perhatian bagi pendengar, (2) sebagai alat pengesahan pranata dan lembaga kebudayaan dalam rangka menjaga sikap sosial masyarakat, (3) sebagai alat pendidikan, digunakan untuk mengoreksi diri setiap harinya, dan (4) sebagai alat pemaksa dan pengawas digunakan sebagai penetapan tanggal peringatan haul di masyarakat Gresik dan sekitarnya.
SAFE ENVIRONMENTAL POLICY IN CONTEXT IMPLEMENTATION OF SUSTAINABLE DEVELOPMENT GOALS
Authors: Dziundziuk Viacheslav , Dziundziuk Boris
Published: April 2024

The article examines the current state of the formation of the state regulatory system and the problematic issues of ensuring a safe environmental policy in the context of the implementation of the goals of sustainable development in Ukraine in new conditions. The theoretical and methodological provisions were substantiated and the conceptual principles of improving the state regulation of the nature protection system were developed. Environmental safety policy is an important component of state policy in the field of national security. In the context of the implementation of the goals of sustainable development in Ukraine, it is necessary to improve the system of state regulation of the nature protection system. Environmental problems can lead to destabilization of society, disruption of the normal functioning of the economy and deterioration of the quality of life of the population. Therefore, it is important to develop and implement effective measures to ensure environmental safety. The measures proposed by the authors of the article are relevant and can contribute to the improvement of the system of state regulation of the nature protection system in Ukraine.
STATE POLICY IN THE ENVIRONMENTAL SPHERE: A SAFE COMPONENT
Authors: Mykhailovska Olena
Published: April 2024

The article examines the relationship between state policy, the environmental sphere, and security. It was determined that the main problem is the development and effective implementation of the state environmental policy, which would ensure sustainable development and environmental safety, taking into account modern environmental challenges. It is emphasized that environmental policy can be integrated into various spheres of social life (economy, social policy, education and health). It has been confirmed that issues of state policy in the environmental sphere require the development of an integrated approach, which will include legislative regulation, scientific and research activities, education and public involvement. The connections between the state policy in the environmental sphere and security (connection with the health and well-being of the population; risks of environmental pollution of air, water and soil; the impact of environmental policy on energy security) have been studied as an important factor that contributes to social stability, strengthens trust to the authorities and raises public awareness of environmental issues, the active participation of the public in the formation and implementation of environmental policy is recognized. The legislative field regarding environmental policy is characterized and the root causes of environmental problems in Ukraine are listed. Environmental risks associated with the conduct of military operations are described. Data from the official resource of the Ministry of Environmental Protection and Natural Resources of Ukraine "EkoZagroza" regarding and impact on the environment are given. The role of public involvement work and educational campaigns aimed at raising citizens' awareness of environmental problems and the need to solve them has been defined. The importance of global environmental challenges and their impact on human health, the economy and the stability of society is revealed. The need to form an integrated approach to environmentally caused diseases in the context of safety is emphasized. The need to involve a wide range of stakeholders, including government institutions, the scientific community, the business sector and civil society, is emphasized. Directions for increasing the effectiveness of state policy in the environmental sphere are presented and their characteristics are given.
INITIATIVE RECONSTRUCTION OF NEGLECTED BUILDINGS AS A WAY OF FORMING HOUSING FUNDS FOR INTERNALLY DISPLACED PERSONS
Authors: Hren Larysa , Sosipatrov Artem
Published: April 2024

The article provides examples of the leadership of representatives of civil society institutions, volunteers who proactively and participatoryly reconstruct buildings, help resettle internally displaced persons who suffered as a result of hostilities caused by Russian aggression. It has been proven that the reconstruction of existing buildings is an effective and quick way to provide internally displaced persons with housing.
Examples of the implementation of projects of the Ukrainian Social Investment Fund (UFSI) are given. Donors of the project in different years were the governments of Germany (KfW), Japan (JSDF), Sweden (SIDA), Great Britain (DFID), the World Bank, the European Union, the Charles Stewart Mott Foundation, the Canadian International Development Agency, the International Renaissance Foundation , the UN Development Program for the reconstruction of existing residential and non-residential buildings with the aim of arranging housing for internally displaced persons, which creates conditions for fruitful cooperation with foreign donors, productive and transparent involvement of financial resources.
ORGANIZATION OF WORK IN EDUCATIONAL INSTITUTIONS FOR CHILDREN WITH SEN WITH DISTANCE EDUCATION (FROM WORK EXPERIENCE)
Authors: Kostina Larysa , Liabakh Natalia
Published: April 2024

The article proves the necessity of ensuring quality education and its accessibility for all segments of the population, for children with special educational needs, in particular. Attention is focused on the organization of psychological assistance, increasing the level of social and psychological support, solving problems that may become obstacles in further adult life, and finding new methods for people with special educational needs during distance education. Examples of the organization of work with students with special educational needs in the Communal Institution "Pokotyliv Lyceum No. 2" of the Kharkiv region are given. The cooperative work of this educational institution with the Information and Resource Center "Without Barriers" of the Scientific and Technical Library of the National Technical University "Kharkiv Polytechnic Institute" was noted. It is emphasized that persons with special educational needs receive high-quality general and professional education is one of the main and integral conditions for their effective socialization, ensuring full participation in society, successful self-realization in various types of professional and social activities.
Clinical Characteristics of Sciatica in Patients with Piriformis Syndrome Improved by Decompression Surgery
Authors: Lee Dong-kwan , Son Byung-chul
Published: April 2024

Objective: To clearly identify the symptoms of sciatica in patients with piriformis syndrome, we retrospectively reviewed patients whose symptoms significantly improved over long-term postoperative follow-up. Methods: Among patients who underwent sciatic nerve decompression for piriformis syndrome over the past 3 years, the preoperative sciatic pain symptoms of 32 patients whose symptoms were confirmed to have improved by more than 50% during more than 1 year of follow-up were analyzed. To identify the characteristics of sciatic pain in piriformis syndrome, we investigated pain when sitting, pain when resting, pain when standing or walking, and pain when resting at night. In addition, the distribution of sciatic pain in the lower back, buttocks, lower extremities, and feet was investigated. Results: The most common symptom was pain when sitting, which was present in 25 patients (81%). Pain characteristically occurred even at rest, occurring in 62.5% of patients while lying down at night and in 53.1% of patients during daytime rest. Sciatic pain from piriformis syndrome was most commonly distributed in the buttock (90.6%) and also present in the lower back (37.5%). Pain was present in the posterior thigh in 23 patients (71.9%), in the calf in 68.8% of patients, and in the foot in 50% of patients. Conclusion: Buttock pain exacerbated by sitting was the most common pattern of pain in patients with piriformis syndrome. However, the sciatic pain of this disease was also found to be characterized by pain that persisted even at rest.
Median Nerve Anatomy and Entrapment Syndromes
Authors: Park Se-Hyuck
Published: April 2024

Peripheral neuropathies, including entrapment or injury, are quite common and are encountered frequently. To ensure accurate diagnosis and effective treatment for these conditions, it is essential to have a comprehensive understanding of peripheral nerve anatomy and assessment techniques. This may involve the use of methods like ultrasonography, as well as requiring clinical proficiency. The median nerve, which is one of the main nerves in the upper extremity, primarily controls motor function in the flexor muscles of the forearm and hand. It is responsible for actions such as wrist flexion and the movement of the first three fingers. The purpose of this article is to enhance understanding and improve the diagnosis of peripheral nerve disorders, with a particular focus on neuropathies associated with the median nerve.
Flowback Rates for Pump-In/Flowback Test
Authors: Wang Rui , Dahi Taleghani Arash , Cai Yuzhe
Published: April 2024

The pump-in/flowback test (PIFT), often referred to as the diagnostic fracture injection test (DFIT) with flowback, offers notable advantages in terms of time efficiency and accuracy, particularly in the context of low-permeability formations. The key to the success of this test lies in the careful selection of an optimal flowback rate to yield meaningful results. The fundamental assumption underlying the pressure analysis of these tests is the uniform closure of fractures during the flowback phase, which is considered the default fracture closure mode in current analyses. In this study, we present evidence that challenges the validity of this assumption, highlighting instances where unsuitable flowback rates can lead to nonuniform fracture closure and result in abnormal pressure data. To address this challenge, we identify different closure modes through the signature of fracture closure in the excessive bottomhole pressure decline curve. Subsequently, we propose an optimal range of flowback rates using a scaling analysis approach to obtain a uniform closure mode in an extended openhole section of a vertical well. Our method has been rigorously validated through 3D numerical simulations and field studies, enhancing its reliability and applicability. This approach helps operators to conduct effective tests in complex situations, overcoming a barrier to widespread test application.
Experimental Study on Low-Temperature-Oxidation Parameters and Simulations of Exothermic Process during Air Injection in Light Oil Reservoirs
Authors: He Wangrong , He Houfeng , Zheng Haoran , Liu Pengcheng
Published: April 2024

The thermal development process for light oil reservoirs using air injection technology is to release heat through low-temperature oxidation (LTO) between the injected air and crude oil and gradually increase the reaction zone’s temperature to displace crude oil. However, existing LTO experimental methods for air injection do not adequately capture the characteristics of LTO and struggle to directly obtain LTO kinetic parameters at low temperatures. In this paper, we used light oil samples from the Huabei Oilfield, China, as the studied objects and proposed innovative methods for obtaining and calculating LTO kinetic parameters. Further, we validated the feasibility of the proposed methods through experimental and numerical simulations. The results indicate that the lower limit temperature at which oxidation parameters can be directly measured through the accelerating rate calorimeter (ARC) experiments is 124°C. We matched the calculations from the ARC experiment curve-extension method for kinetic parameters with the results from both the high-pressure thermogravimetric analyzers (HP-TGA) experiment and the ramped thermal oxidizer (RTO) experiment. The fit between these results indicates that three methods are suitable for obtaining LTO parameters and can be used to derive chemical equations for LTO reactions in numerical simulation models. The simulation results from the reservoir scale indicate that, following air injection into the light oil reservoir, the peak temperature at the leading edge of the high-temperature zone reaches 370.9°C. The interaction between crude oil and air remains in the LTO phase, facilitating a sustained thermal accumulation within the reservoir. This study can provide a reference for reservoir development under similar conditions.
Mentorship Matters”: A Comprehensive Exploration of Student Perspectives in Medical and Dental Training
Authors: Ali Sara , Ganji Kiran Kumar , Shabbir Muhammad , Bandy Altaf , Darraj Ali Qassim , Khattak Osama , Iqbal Azhar , memon Muhammad Rizwan , Sultan Sherif El Sayed
Published: April 2024

Background & Objective: Mentoring, a time-honoured practice dating back to ancient Greece, has gained renewed significance in educational settings. This study explores the perceptions of medical and dental students in mentoring programs, emphasizing the importance of mentoring for academic growth, career development, and personal improvement.
Materials & Methods: A comparative cross-sectional study was conducted in a medical and dental colleges of Pakistan & Egypt, utilizing a questionnaire-based survey with Likert Scale responses. Participants included 306 students, with data collected through convenience sampling. Demographic data and mentoring program perceptions were assessed. Two themes: Mentorship Satisfaction and Support and Impact of Mentoring on Professional and Personal Development were linked to the questionnaire to assess their impact on student perception. Data was analysed using
Results: Analysis revealed a diverse participant distribution across gender, program type, and academic levels. Ordinal logistic regression identified significant factors influencing mentorship satisfaction and support. Fourth-year students exhibited higher satisfaction odds, while negative impacts on professional and personal development decreased satisfaction odds. Positive perceptions of navigating the mentorship compass significantly increased satisfaction odds. Ordinal logistic regression analysis was performed to asses the impact student perception with mentorship.
Conclusion: Tailored mentorship programs, acknowledges the nuanced impact on students' satisfaction, professional development, and personal growth. As a two-way process, effective mentorship fosters a collaborative environment, positively influencing both mentors and mentees. Understanding these dynamics is crucial for optimizing mentoring relationships and promoting successful academic and professional journeys.
A cavotricuspid isthmus dependent flutter with an unexpected left atrial activation sequence: A case report
Authors: Tabbah Randa , Abi-Saleh Bernard
Published: April 2024

Introduction: The isthmus-dependent right atrial flutter is a known arrhythmia, but few studies described the sequence activation of the left atrium. It is well established that the interatrial connection occurs through different pathways: the coronary sinus (CS), the Bachmann's bundle and the fossa ovalis. We describe a case of a cavotricuspid isthmus-dependent right atrial flutter with an unexpected left atrial activation sequence. Case presentation: A 47-year-old female with scleroderma and a history of isolated right ventricular cardiomyopathy had recurrent atrial flutter episodes despite medical therapy. The patient was still symptomatic despite full medical therapy. She presented to the electrophysiology (EP) laboratory for mapping and ablation of atrial flutter with 2:1 and 3:1 conduction. A decapolar deflectable CS catheter placed in the coronary sinus showed a distal to proximal CS activation with a flutter cycle length of 240 msec. Then, the Cavo Tricuspid Isthmus (CTI) demonstrated a concealed entrainment with a post-pacing interval (PPI) almost equal to the total cycle length (TCL) confirming the diagnosis of an isthmus-dependent flutter. The CS activation in sinus rhythm also showed a distal to proximal activation. This confirmed that the CS and the left atrium (LA) are being activated most probably through the Bachman bundle anteriorly and superiorly. CTI line was performed under intracardiac echo (ICE) guidance. Clinical improvement was noticed. A distal to proximal CS activation doesn’t exclude a right atrial arrhythmia. Conclusion: A systemic entrainment mapping of both the right and left atrium is crucial to prevent unneeded transseptal puncture.
Exploration of the Immune-related Gene Set Score (IRGS) in the Prognosis and Immunotherapy of Lung Adenocarcinoma (LUAD)
Authors: Li Dongfang , Xie Yuancai , Yan Jun , Wu Mengxi , Zhang Jianhua , Liu Jixian
Published: April 2024

Background: With the rapid development of immunotherapy for solid tumors, the exploration of immune characteristics becomes more and more important. Due to the high morbidity and mortality of LUAD in Chinese population, it is of great significance to explore its immune characteristics.
Methods: Eight GEO cohorts were used to screen for immune and prognostically relevant genes. An IRGS predictive model was constructed using the ssGSEA algorithm and internally validated. The performance of the model was further verified in five external validation cohorts. To evaluate immune cell infiltration, TIMER, XCELL, and CIBERSORT were applied to quantify the relative proportions of infiltrating immune cells.
Results: Patients with high IRGS exhibited significantly better overall survival (OS) compared to those with low IRGS (HR = 0.56, 95% CI 0.46-0.68, P <0.001) in the training set. The same results were obtained in the validation set (HR = 0.45, 95% CI 0.33-0.6, P <0.001). Further validation in five external cohorts yielded consistent results (GSE31210: P <0.001; GSE68465: P =0.039; Chen_2019: P =0.031; TCGA_LUAD: P =0.002; CPTAC_LUAD: P =0.036). In the tumor microenvironment (TME) analysis, patients with high IRGS had higher levels of T cells, B cells, DC cells, and neutrophils. Immunotherapy cohort analysis in a public cohort showed that patients with high IRGS had better progression-free survival (PFS) after immunotherapy (P=0.013).
Conclusions: Patients with high IRGS demonstrated better prognosis and improved immune efficacy. The IRGS model may possess better predictive performance compared to existing immune and genomic instability markers, indicating its potential value for clinical applications.
Predictors of Spontaneous Abortion Among Women Attending Referral and Specialized Public Hospitals of East Ethiopia, A Case-Control Study
Authors: Amsalu Sewmehon , Kasahun Manaye , Hailu Mickiale , Melkamu Netsanet , Yigezu Muluken , Sintayehu Yitagesu , Tekle Yared
Published: April 2024

Background
Spontaneous abortion is one of the most common complications of early pregnancy, occurring in 15–20% of pregnant women. Every year, an estimated 23 million miscarriages occur worldwide, resulting in 44 pregnancy losses every minute. Consistent findings show that spontaneous abortion has a negative impact on current and consecutive pregnancies. It also has an enormous economic impact. When all of these factors are combined with the idiopathic nature of the problem, identifying predictors of spontaneous abortion will have a significant impact on preventing the problem. However, no studies have been conducted in Ethiopia on this topic. Therefore, this study aims to assess the predictors of spontaneous abortion among women attending referral and specialized public hospitals in Eastern Ethiopia.
Methods
An institutional-based unmatched case-control study design was used. Three hundred seventy-one (371) cases and three hundred seventy-one (371) controls were studied. The data were collected by using an interviewer-administered structured questionnaire. The collected data were entered into Epi data version 4.6 and then exported to SPSS window version 25 for analysis. Bivariate and multivariate analyses were used to determine the associations between each independent variable and the outcome variable. All the variables with a P value ≤ 0.25 in the bivariate analysis were included in the final model of multivariable analysis to control for possible confounders. A P value < 0.05 was considered to indicate a statistically significant association.
Result
The following predictors were significantly associated with spontaneous abortion, intended pregnancy [AOR = 0.443, 95% CI: (0.279, 0.703)], folate intake during the current pregnancy [AOR = 0.067, 95% CI: (0.042, 0.106)], coffee consumption [AOR = 3.699, 95% CI: (2.341, 5.846)], stressful life events [AOR = 7.55, 95% CI: (3.932, 14.496)], and history of spontaneous abortion [AOR = 8.86, 95% CI: (3.197, 24.604)].
Conclusion
This study provides evidence that several predictors are independently associated with spontaneous abortion. Importantly, many of these factors can be modified or prevented through appropriate awareness and education among reproductive-age women. By addressing these risk factors, the incidence of spontaneous abortion can be reduced.
Nicotinamide N-methyltransferase enhances paclitaxel resistance in ovarian clear cell carcinoma
Authors: Kikuchi-Koike Ryoko , Sakamoto Masaru , Sasajima Yuko , Miyagawa Yuko , Uozaki Hiroshi , Umayahara Kenji , Hashimoto Kei , Takahashi Yuko , Takasaki Kazuki , Kihira Chikara , Nishida Haruka , Ichinose Takayuki , Hirano Mana , Hiraike Haruko , Nagasaka Kazunori
Published: April 2024

Background. Growing evidence suggests that nicotinamide N-methyltransferase (NNMT), an S-adenosyl-L-methionine (SAM)-dependent cytosolic enzyme, plays an essential role in cancer progression. Recently, it was reported that NNMT is involved in methylation metabolism and tumorigenesis and is associated with poor prognosis in a number of cancers. It has also been reported that NNMT is overexpressed in the stroma of advanced high-grade serous carcinomas and may contribute to poor survival. The aim of this study was to identify novel biomarkers that predict resistance in paclitaxel-resistant advanced or recurrent ovarian clear cell carcinoma (OCCA) and to evaluate their clinicopathologic significance.
Methods. Four OCCA cell lines (ES-2, KK, OVMANA, and OVTOKO) were divided into paclitaxel high and low sensitivity groups by WST-8 assay and fluorescence-labeled two-dimensional electrophoresis (2D-DIGE) was performed. Protein spots with different expression intensities in each drug-sensitive group were analyzed by mass spectrometry to identify the proteins.
Results. NNMT was detected as a protein molecule upregulated in the paclitaxel-resistant group, and knockdown by NNMT siRNA increased paclitaxel sensitivity in the NNMT-expressing ovarian clear cell carcinoma cell lines OVTOKO and RMG1. Furthermore, in analysis of clinical tissue samples, no deaths were observed in 7 patients with low NNMT expression in the cytoplasm of cancer cells.
Conclusions. High NNMT expression in the cytoplasm of cancer cells is associated with low sensitivity to paclitaxel in OCCA and may have prognostic implications; knockdown of NNMT expression also reduced paclitaxel efficacy. Therefore, targeted therapies that reduce cytoplasmic NNMT expression levels may increase the sensitivity of OCCA to paclitaxel.
Is a vibration isolation system required for Gateway? Mitigation of force and vibration transmission by the HIFIm jump sled during repeated jumping in microgravity
Authors: Cleather Daniel J , Kennett John E
Published: April 2024

Exercise countermeasures are a ubiquitous part of space habitation due to the need to mitigate the deconditioning effect of microgravity. However, exercise in space creates forces that need to be isolated from the habitat, and these so-called Vibration Isolation Systems (VIS) are typically large and heavy. High Frequency Impulse for Microgravity (HIFIm) is an exercise countermeasure that is designed to minimize force and vibration transmission to the spacecraft without the need for an additional VIS. The purpose of this study was to evaluate the effectiveness of HIFIm in mitigating force transmission in microgravity during parabolic flight. Force between HIFIm and the aircraft was measured using a custom-made arrangement of load cells during repeated jumping by two participants. Mean peak force transmission to the aircraft was 4.79 ± 0.68 N.kg-1. In addition, the frequency spectra for the upper and lower fixations to the aircraft were within the envelope of what is permissible for an exercise countermeasure on Gateway. These data support the design concept of HIFIm and suggest that HIFIm could be installed in a space habitat with no, or minimal, additional VIS. Measuring the force and vibration transmission of exercise countermeasures in microgravity during parabolic flight is highly challenging due to the safety constraints of the experimental platform and the extreme changes in acceleration (from 0-1.8g). The fact that this performance can be directly measured for HIFIm is a key advantage. The results presented here add to the mounting evidence that HIFIm is the future of exercise countermeasures.
Evaluating the Feasibility of AI-Predicted mpMRI Image Features for Predicting Prostate Cancer Aggressiveness: a Multicenter Study
Authors: Wang Kexin , Luo Ning , Sun Zhaonan , Zhao Xiangpeng , She Lilan , Xing Zhangli , Chen Yuntian , He Chunlei , Wu Pengsheng , Wang Xiangpeng , Kong ZiXuan
Published: April 2024

Objective
To evaluate the feasibility of utilizing artificial intelligence (AI)-predicted multiparametric MRI (mpMRI) image features for predicting the aggressiveness of prostate cancer (PCa).
Materials and methods
A total of 878 PCa patients from 4 hospitals were retrospectively collected, all of whom had pathological results after radical prostatectomy(RP).A pre-trained AI algorithm was used to select suspected PCa lesions and extract lesion features for model development. The study evaluated five prediction methods, including 1) A clinical model of clinical features and image features of suspected PCa lesions selected by AI algorithm, 2)the PIRADS category, 3)a conventional radiomics model, 4) a radiomics model based on deep learning, 5)biopsy pathology.
Results
In the externally validated dataset, the deep learn-based radiomics model showed the highest area under the curve (AUC 0.700 to 0.791).It exceeded clinical model (AUC 0.597 to 0.718), traditional radiomic model (AUC 0.566 to 0.632), PIRADS score (AUC 0.554 to 0.613) and biopsy pathology (AUC 0.537 to 0.578). And the AUC predicted by the model did not show statistically significant difference among the three externally verified hospitals (P > 0.05).
Conclusion
Deep-radiomics models utilizing AI-extracted image features from mpMRI images can potentially be used to predict PCa aggressiveness, demonstrating a generalized ability for external validation.
Comparison of Outcomes in Discectomy with or without Annulus Fibrsous Repair for the Treatment of Lumbar Herniated Discs: A Systematic Review and Meta-Analysis
Authors: Zhao Yize , Huang Yong , Wang Zhe , Feng Ganjun , Qian Cheng , Liu Limin , Song Yueming
Published: April 2024

Objective
The aim of the study is to evaluate whether discectomy combined with annulus fibrosus repair to treat lumbar disc herniations is effective and investigate the implications of each annulus fibrosus repair method for clinical practice.
Methods
PRISMAP guidelines were followed in this review. PubMed, Embase, Cochrane, Web of Science databases and the reference list grey literature were searched for randomized controlled trials (RCTs), screened the studies according to inclusion criteria, and extracted the data and analyzed by Review Manage (version 5.4).
Results
10 RCTs with 2197 patients were included in this study. The results showed that the risk of post-operative reherniations (RR: 0.42, 95%CI [0.30, 0.58], P < 0.00001) and the risk of reherniation-related reoperations (RR: 0.63, 95%CI [0.46, 0.87], P = 0.005) were markedly lower in the discectomy with annulus fibrsous repair (DAFR) group compared with discectomy alone (DA) group. The two groups had no significant difference in ODI, VAS-back pain, VAS-leg pain, and SF-scale. The DAFR group had a longer operative time and a higher postoperative disc height than the control group. It was obtained by the subgroup analysis that the Barricaid repair method was more effective in reducing the risk of reherniations and the risk of reherniation-related reoperations compared with other repair methods relatively.
Conclusion
Discectomy with annulus fibrosus repair reduced the risk of reherniations and the risks of reherniation-related reoperations but could not reduce postoperative pain and improve overall health status better than discectomy alone. Discectomy with annulus fibrosus repair had a better ability to maintain disc height but had a longer operative time.
Sex-Specific Cardiovascular Adaptations to Simulated Microgravity in Sprague-Dawley Rats
Authors: Yamaleyeva Liliya , Elsangeedy Ebrahim , Yamaleyeva Dina , Edenhoffer Nicholas , Deak Allyson , Soloshenko Anna , Ray Jonathan , Sun Xuming , Shaltout Omar , Diaz Nildris Cruz , Westwood Brian , Kim-Shapiro Daniel , Diz Debra , Soker Shay , Pulgar Victor , Ronca April , Willey Jeffrey
Published: April 2024

Men and women have different cardiovascular responses to spaceflight; however, few studies have focused on direct comparisons between sexes. We investigated the mechanisms of aortic stiffness in socially and sexually mature 20-week-old male and female Sprague Dawley (SD) rats exposed to hindlimb unloading (HLU) for 14 days. Pulse wave velocity (PWV) was greater in the aortic arch of females after HLU versus control females. HLU had no effect on aortic PWV in males. Aortic α smooth muscle actin, myosin, collagen, elastin, and collagen-to-elastin ratio were not different in rats of either sex following HLU. The levels of G protein-coupled estrogen receptor (GPER) were lower in the aorta of SD females exposed to HLU compared with female controls but were not altered in males. These changes in HLU females were associated with lower aortic PPARγ and increased oxidative stress markers in association with diastolic dysfunction. GPER agonist G1 prevented the increase in PWV and 8-hydroxy-2'-deoxyguanosine without altering PPARγ or p47phox in HLU females. This study highlights sex-specific vascular adaptations to the state of simulated microgravity.
The Impact of REM Sleep Loss on Human Brain Connectivity
Authors: Shi Jie , Di Tianqi , Zhang Libo , Meng Shi-Qiu , Liu Wangyue , Guo Yang , Zheng Enyu , Xie Chao , Xiang Shitong , Jia Tianye , Lu Lin , Sun Yan
Published: April 2024

Brain function is vulnerable to the consequences of inadequate sleep. The REM sleep phase has been implicated in coordinating various brain structures and is hypothesized to have potential links to brain variability. However, traditional imaging research have encountered challenges in attributing specific brain region activity to REM sleep, remained understudied at the whole-brain connectivity level. Through the spilt-night paradigm, distinct patterns of REM sleep phases were observed among the full-night sleep group (n = 36), the early-night deprivation group (n = 41), and the late-night deprivation group (n = 36). We employed connectome-based predictive modeling (CPM) to delineate the effects of REM sleep deprivation on the functional connectivity of the brain (REM connectome) during its resting state. The REM connectome was characterized by stronger connectivity within the default mode network (DMN) and between the DMN and visual networks, while fewer predictive edges were observed. Notably, connections such as those between the cingulo-opercular network (CON) and the auditory network, as well as between the subcortex and visual networks, with the edges of the thalamus contribute also made significant contributions. These findings elucidate the neural signatures of REM sleep loss and reveal common connectivity patterns across individuals, validated at the group level.
A Phase I Study of sequences of the CDK4/6 Inhibitor, Ribociclib Combined with Gemcitabine in Patients with Advanced Solid Tumors
Authors: Seetharam Mahesh , Norman Aurora , Allred Jacob , Kong Jianping , Opyrchal Mateusz , Ma Wen Wee , Lou Yanyan , Dy Grace K , Mahipal Amit , Weroha John , Wahner-Hendrickson Andrea , Reid Joel M. , Adjei Alex A.
Published: April 2024

Background:
Based on preclinical data showing addition of CDK4/6 inhibitors to gemcitabine is synergistic, ribociclib was evaluated in combination with gemcitabine to determine the maximum tolerated dose (MTD) and dose limiting toxicities (DLT).
Methods:
In this single arm multicohort phase I trial, we evaluated the safety and efficacy of Ribociclib plus Gemcitabine in patients with advanced solid tumors. Patients received Gemcitabine intravenously on days 1 and 8 followed by Ribociclib days 8–14, with treatment repeated every 3 weeks.
Results:
The study enrolled 43 patients between October 2017 and September 2019. The escalation phase (19 patients) determined the MTD and recommended phase II dose (RP2D) to be ribociclib 800mg daily and gemcitabine 1000mg/m2 for the expansion phase (24 patients). One patient experienced Grade 4 thrombocytopenia. Eleven patients experienced Grade 3 adverse events (AE), the most common being neutropenia, thrombocytopenia, and anemia. No partial or complete responses were observed. 15/22 (68%) of efficacy evaluable patients who received the MTD achieved best response of stable disease.
Conclusions:
The addition of Ribociclib to Gemcitabine was tolerated well and yielded stability of tumors in both cohorts. Ribociclib and gemcitabine could have synergistic activity in certain tumor types, and our data provides support for the combination.
Clinical Trial Registration: NCT03237390
The causal relationship between insomnia and atopic dermatitis: Mendelian Randomization Analysis
Authors: Li fawen
Published: April 2024

Objective. This two-sample Mendelian randomization study aimed to delve into the effects of genetically The Impact of Insomnia on Atopic Dermatitis.
Methods. Exposure data were extracted from genome-wide association study (GWAS) data of 462,341 European individuals with insomnia, while outcome data were extracted from GWAS data of 796,661 European individuals with atopic dermatitis for initial analysis. Subseguently, Mendelian randomization analyses were conducted with inversevariance weighted (lvw, weighted median and Mendelian randomization-Egger regression). Furthermore, sensitivityanalyses were then conducted to assess the robustness of our results.
Results. The positive causality between genetically predicted leptin level and risk of total OA was indicated byIv fodds ratio (OR): 1.51, 95% Cl: 1.04-2.20] and weighted median (0R: 1.31, 95% Cl: 0.71-2.18). In this analysis, evidence indicates that insomnia is detrimental to atopic dermatitis，The findingsof this study were verified by the results from sensitivity analysis.
Conclusions.The association between insomnia and the risk of atopic dermatitis has been established.
Case report: Coexistence of rectal signet ring cell carcinoma with neuroendocrine components
Authors: Xu Ling , He Zhefeng , Fu Chao , Wu Yiyang , Wu Anwei , Tian Guojiang , Huang Jianfei , Liu Xibo , Wang Qi
Published: April 2024

Background: Signet ring cell carcinoma is a rare histological type among the various forms of colorectal cancers. Even rare is when it coexisted with neuroendocrine components in one tumor. To date, there is little literature reported case of colorectal cancer diagnosed as signet ring cell carcinoma with neuroendocrine components.
Case presentation:This report presents a unique case manifested as obstructed defecation for more than one month but with negative endoscopic biopsies. Laparoscopic abdominoperineal resection was performed. Based on the postoperative pathology, the patient was finally diagnosed as signet ring cell carcinoma with neuroendocrine differentiation.
Discussion and conclusions: We highlight the rare coexistence of signet ring cell carcinoma and neuroendocrine differentiation in this case. We also aim to pose the pitfalls and share lessons during our diagnosis and treatment process.
The seven-day cumulative post-esophagectomy inflammatory response predicts cancer recurrence
Authors: Fujiwara Yoshinori , Endo Shunji , Higashida Masaharu , Kubota Hisako , Yoshimatsu Kazuhiko , Ueno Tomio
Published: April 2024

Background
Therelationship between postoperative cumulative systemic inflammation and cancer survival needs to be investigated. We developed an approach for the prognostication of postoperative esophageal cancer by establishing low and high cut-off values for the C-reactive protein (CRP) area under the curve (AUC) at 7 and 14 days after esophagectomy.
Methods
This study included 125 consecutive patients with biopsy-proven invasive esophageal squamous cell carcinoma (SCC) who underwent esophagectomies. Postoperative CRP levels were analyzed for the first 14 days after surgery. The AUC on days 7 and 14 were calculated and compared with clinicopathological features and survival.
Results
The cut-off values for CRP at 7 days (CRP 7 d) and 14 days (CRP 14 d) were 599 mg/L and 1153 mg/L, respectively. The patients in the low CRP 7 d group had significantly better recurrence-free survival (RFS) and overall survival (OS) than those in the low CRP 14 d group(P=0.0117,0.0087, respectively). No difference in survival was observed between the low and high CRP 14d group. The OS rates in the high CRP group at post-operative days (PODs) 1, 3, 10, and 14 were significantly lower than those in the low CRP group. Postoperative complications were more common in the high CRP group on PODs 3, 10, and 14. Univariate analyses revealed that pTNM stage, depth of tumor invasion, tumor location, lymph node involvement, and CRP 7 d were significant prognostic factors for both OS and RFS. The Cox proportional hazards model identified pTNM, tumor location, and CRP 7 d as independent prognostic factors for RFS and OS.
Conclusions
Early prediction of patients with postoperative complications and adequate management will suppress the elevation of CRP 7 d and further suppress the CRP value in the late postoperative period, which may improve the prognosis of esophageal cancer patients after esophagectomy.
Association Between Abdominal Aortic Calcification and adjacent vertebral fracture after percutaneous kyphoplasty: a case control study.
Authors: Yu Weijie , Chen Minghang , Xu Guoting , Yue Xianlong , Zhang Yihan , Jia Mengxian , Teng Honglin , Chen Bi
Published: April 2024

Purpose
To demonstrate the potential impact of abdominal aortic calcification (AAC) as a risk factor for the occurrence of adjacent vertebral compression fracture (AVCF) after percutaneous kyphoplasty surgery.
Methods
A review of imaging and demographic data of patients treated with percutaneous kyphoplasty (PKP) for osteoporotic vertebral compression fractures (OVCF) was conducted. The patients were divided into two groups: groups with and without AVCF. The severity of AAC was assessed from the lateral spine images using the AAC24 score. Data on patients with and without AVCF were compared and independent risk factors were identified using regression analysis.
Results
32 patients (12.6%) developed AVCF postoperatively. AVCF after PKP was associated with BMD, cardio/cerebrovascular diseases, history of vertebral fractures, Vitamin D, AAC, postoperative kyphotic angle, postoperative vertebral body’s collapse rate, collapse height restoration rate, and bone cement distribution according to a univariate analysis (P < 0.05). The results of multifactorial logistic regression analysis indicate that BMD, AAC, bone cement distribution (impact), and cardio/cerebrovascular diseases are independent predictors of AVCF after PKP (P < 0.05). As shown by the ROC curve, the AAC had an area under the curve of 79.3%, a sensitivity and specificity of 84.4% and 62.9%, respectively, and a cut-off value of 5.0 points of the AAC24 score.
Conclusions
BMD, AAC, bone cement distribution (impact), and cardio/cerebrovascular diseases are independent risk factors for AVCF after PKP. In cases where the AAC24 score exceeded 5.0 points, the incidence of AVCF increased significantly.
Clinical audit on the root cause analysis of waiting time for surgical patients who undergo emergency surgery in Debre Markos Comprehensive Specialized Hospital, Ethiopia, 2023
Authors: Guadie Yitayal , Godie Yohannes , Tadele Melese
Published: April 2024

Background
Emergency surgery is characterized as a life-saving procedure performed right away, along with resuscitation and surgical care. The study aims to improve the root causes of waiting time for patients who undergo emergency surgical patients.
Methodology
: All consecutive emergency surgical patients who undergo emergency surgery are included in the study period. The data were checked, coded, entered, and cleaned by using SPSS version 20. Descriptive analysis was performed using SPSS version 20. Results will be expressed in graphs, frequencies, and percentages. All the data were collected based on NSW emergency surgery guidelines and based on literature review data collection formats and directly changed into open-ended question forms.
Result
A total of 50 surgical emergency patients were operated in a major operation theater at Debre Markos Comprehensive Specialized Hospital during the study period. Thirty-nine (78%) of surgical emergency patients had prolonged wait times with a mean of 8 hours with a standard deviation of 4.44. Of those the cause of waiting time was around 22% due to preoccupation with the operation theater, 18% due to lack of OR supplies like Gown/drip, and water, 16% due to financial constraints and logistics of the patients, 12%patients delayed giving consent, 12%patient delayed due to procedures need special intervention.
Conclusion and Recommendation
The mean waiting time of emergency surgical patients who undergo emergency surgery in the Debre Markos Compressive and Specialized Hospital was 8 hrs. with a standard deviation of 4.44. A total of 78% of emergency surgical patients experience prolonged waiting times because of their preoccupation with the operation theater. Prioritization of emergency cases following emergency surgery guidelines is required in the Debre Markos compressive and specialized hospital to replace the current system.