bluuebunny/crossref_metadata_2025 huggingface dataset:
Onconephrology: Acute kidney injury in cancer patients
Authors: Kolesnyk M.
Published: September 2023

Acute kidney injury (AKI) is a common complication of cancer, occurring in up to 50% of neoplastic patients during the natural course of their disease. Furthermore, it has a significant impact on key outcomes, such as overall prognosis, length of hospitalization, and costs. AKI in cancer patients has various causes, including patient-related, tumor-related, or treatment-related factors.

Patient-related risk factors for AKI are similar to those in the general population. Tumor-related risk factors can involve compression, obstruction, direct kidney infiltration by the tumor, as well as precipitation, aggregation, crystallization, or misfolding of paraproteins in conditions like multiple myeloma. Treatment-related risk factors are the most commonly observed in clinical practice and can present as features of tumor lysis syndrome or, for example, immune checkpoint inhibitor-related AKI.

In the absence of validated biomarkers for AKI, a multidisciplinary clinical approach involving oncologists, intensivists, nephrologists, or onconephrologists is essential. This approach incorporates thorough assessment, the use of appropriate preventive measures, and early intervention to reduce the incidence of AKI in cancer patients. Understanding the essence of preventive measures, timely initiation of treatment, and knowing when to terminate treatment will reduce the frequency of this life-threatening condition and improve the effectiveness of cancer treatment and the quality of life and life expectancy of cancer patients.

This work aims to improve physicians' awareness of the latest data on the prevention, diagnosis, and treatment of AKI specifically related to oncopathology, tumor lysis syndrome, and acute kidney injury induced by cancer immunotherapy drugs.
STUDI ANALISIS IMPLEMENTASI KURIKULUM MERDEKA PADA MATA PELAJARAN SEJARAH DI SMA BAITUL ARQOM BALUNG KABUPATEN JEMBER
Authors: Hamdani M. Iqbal Ibrahim
Published: September 2023

Penelitian ini mempunyai tujuan memperoleh gambaran mengenai kesiapan sekolah dan guru sejarah dalam IKM, bagaimana implementasi Kurikulum Merdeka di SMA Baitul Arqom pada mata pelajaran sejarah di kelas X, serta bagaimana perangkat pembelajaran  yang digunakan oleh guru sejarah di kelas X dalam mengimplementasikan Kuriklum Merdeka. Penelitian ini menggunakan pendekatan kualitatif deskriptif dengan metode pengumpulan data melalui observasi, wawancara, dokumentasi serta studi literatur. Hasil penelitian diperoleh bahwa penerapan Kurikulum Merdeka di SMA Baitul Arqom telah berjalan dengan baik dengan memfasilitasi guru untuk mengikuti serangkaian pelatihan dan sosialisasi baik secara langsung masupun secara daring. Demikian juga dengan mewajibkan para guru, khususnya guru sejarah untuk mengikuti pelatihan mandiri melalui aplikasi Platform Merdeka Mengajar (PMM). Sementara itu perangkat pembelajaran juga mengalami perubahan dari kurikulum sebelumnya, yaitu digunakannya istilah-istilah baru misalnya Alur Tujuan Pembelajaran (ATP), Capaian Pembelajaran (CP), Tujuan Pembelajaran dan beberapa istilah yang lain. Meskipun pada tahapan implementasinya, guru masih berusaha beradaptasi dengan penggunaan istilah-istilah tersebut. Selain itu, yang menjadi penekanan dalam implementasi Kurikulum Merdeka ini yaitu adanya Profil Pelajar Pancasila.
Penerapan Discovery learning Untuk Meningkatkan Historical explanation dan Hasil Belajar Peserta didik Kelas XII IPS di SMA K.H. Agus Salim Tahun Ajaran 2021/2022
Authors: Wati Sindhy Trixiana , Hamdani M. Iqbal Ibrahim , Arifin Ilfiana Firzaq
Published: September 2023

Pembelajaran sejarah menurut kurikulum 2013 mempunyai tujuan yaitu salah satunya mengembangkan kemampuan historis (historical explanation) yang menjadi dasar untuk kemampuan berpikir logis, kreatif, inspiratif dan inovatif. Tapi kenyataan di sekolah masih banyak mata pelajaran sejarah yang diajarkan secara konvensional tanpa melihat tujuan pembelajaran yang dicapai sehingga tujuan penelitian ini adalah penerapan model Discovery learning untuk meningkatkan historical explanation dan hasil belajar peserta didik. Lokasi penelitian di sekolah KH. Agus Salim pada kelas XII IPS di tahun ajaran 2021/2022. Penelitian ini menggunakan desain penelitian PTK. Penelitian dilakukan selama 2 siklus yaitu siklus 1 dan siklus 2. Analisis data yang digunakan adalah kuantatif dan kualitatif. Hasil penelitian menunjukkan bahwa indikator historical explanation mengalami peningkatan pada siklus 1 dan siklus 2. Hasil belajar peserta didik juga mengalami peningkatan pada siklus 1 dan siklus 2 diatas kriteria ketuntasan minimal 70.
”E-POSTER SEBAGAI MEDIA PEMBELAJARAN SEJARAH UNTUK MENUMBUHKAN KESADARAN SEJARAH PADA SISWA KELAS X IPS 1 DI SMAN 1 KENCONG”
Authors: Astutik Wiji , Arifin Ilfiana  Firzaq , Hamdani M. Iqbal  Ibrahim
Published: September 2023

Abstrak

Keterlibatan perempuan menjadi biasa dan bukan masalah hanya demi untuk terpenuhinya kebutuhan hidup sehari-hari. Perempuan ikut terlibat dalam perdagangan hasil tangkap ikan. Perempuan berbondong di tepian dermaga untuk mengambil ikan hasil tangkapan para nelayan laki laki yang umumnya adalah suami-suami nelayan perempuan. Dengan berbekal  timbangan kecil para perempuan berkerumun di TPI pada dini hari, umumnya masyarakat pesisir menyebutnya Reng Timbengan. Aktifitas perdagangan pada dini hari terlihat sudah umum dalam masrakat di kalangan perempuan nelayan Pesisir Besuki. Mereka terlibat aktif untuk mempertahankan perekonomian keluarga dengan bentuk kerja sama yang sangat hebat. Tidak ada istilah tabu dalam peran ini, sebab meraka memahami bagaimana dapat bekerja dengan memperoleh hasil maksimal untuk kelangsungan hidup rumah tanggan nelayan tradisional. Kajian ini menarik menurut penulis sebab tidak semua wilayah pesisir memiliki keunikan dalam peran perempuan yang ikut terlibat dalam perdagangan ikan meski hanya dalam kapasitas yang kecil. Peran ekonomi rumah tangga nelayan yang sudah disepakati dengan tujuan untuk keberlangsungan ekonomi rumah tangga nelayan sederhana.
Contributions of Procedural Memory to Emergent Reading in Older Children
Authors: Hannon Joelle , Zinszer Benjamin D. , Kouadio Aya Élise , Tanoh Fabrice , Earle F. Sayako , Jasińska Kaja Kinga
Published: September 2023

Research on emergent reading has focused almost exclusively on children who begin learning to read by age 5-6, despite the fact that many children around the world begin learning to read later in childhood. Little is known about how older children learn to read for the first time. Importantly, procedural learning supports children’s ability to acquire new skills implicitly and apply those skills with automaticity. Procedural learning is therefore thought to support early reading and reading-related skills, such as phonological awareness. However, as children age they may become less reliant on procedural learning. Older children learn new language skills through largely explicit memorization as opposed to implicit procedural learning, and the same is potentially true for language adjacent skills such as reading. Older children may rely less on procedurally supported phonological awareness when reading for the first time and instead rely on explicit skills such as vocabulary. We examined the role of procedural learning in emergent reading across different ages (9-15 years), focusing on low-literacy communities in rural Côte d’Ivoire, where many children remain in emergent stages of reading even at the end of primary school and age for grade is highly variable. We find that the relation between phonological awareness and reading, and vocabulary and reading among older emergent readers depends on procedural learning.
Social Media Data in the Big Data Environment
Authors: OSAULENKO O. , HOROBETS O.
Published: September 2023

The article contains results of a study of social media data (SMD) which, being distinct from conventional data by their origin, require special methods for collection, processing and analysis. As shown by a literature review, in spite of great many research publications devoted to social media research and big data analysis, the SMD potential as a big data component still remains inadequately explored.     

Two approaches to research and analysis of SMD were highlighted in course of the study, in which SMD are addressed as an object of Internet statistics and an object of big data. When SMD are explored as an object of Internet statistics, collection of anonymized data is performed using the services that have network protocols for collection and analysis of data on social media customers using statistical methods. When SMD are explored as an object of big data, the collection is performed mostly by artificial intellect, whereas the storage and processing is operated by databases designed for large scopes of data and software with statistical data processing applications.          

The social media most popular with users in 2020 were identified in the study. Statistical indicators for assessment of users’ feedback, available now for statistical assessments of social media communities, are given. The study revealed several problems which solutions would require, apart from a multifaceted and complex approach to collection and processing, highly competent teams of specialists in various subject fields, including experts in computations, experts in machine learning and statisticians.
Effective Communication Management: A Factor for Development of International Companies in Our Day
Authors: HRYNCHAK N. , BULAKH Т. , IVASHCHENKO О.
Published: September 2023

The purpose of communication management at company level is to create and exploit all the categories of company assets by building up the communication space in a way to achieve the company competitiveness. Therefore, the quality of communication management in companies has become an indicator of their ability to create an internal and external environment that will help them gain the necessary market advantages.  

The article contains results of an analysis of the phenomenon of communication management and causes of disruptions of effective communications in international companies. A review of previous research shows that international companies operating in multicultural environments face communication barriers affecting the performance of international partners. But once built in a right manner, communication management enables to overcome such cross-cultural barriers. When the peculiarities of cross-cultural communications are accounted for, it will allow to predict the behavior of foreign partners and avoid mistakes in management of international organizations and projects. Two aspects have critical importance for the prevention or quick settlement of conflicts: (i) a cautious and balanced strategic policy of company management, the readiness to grasp the causes of conflicts and change policy schemes to achieve a reasonable compromise, flexibility and adaptability of an organizational structure; (ii) deep awareness of the cultural environments in which an organization operates, and of the cultural origins of its staff.         

 It is concluded that due consideration for the cultural diversity can strengthen mutual understanding between the partners in communication. It is shown that communication management has impact on the organizational communication climate, whereas the latter have implications for future performance of international companies. The organizational communication climate is a proxy of the relationship between communication management and prevention of conflicts.
An approach to forecasting promising areas of development of the robotics industry based on statistical reports of the International Federation of Robotics (IFR) in conditions of economic uncertainty
Authors:   Russian State Scientific Center for Robotics and Technical Cybernetics, Nikolaev Alexander
Published: September 2023

A simple method of forming a forecast rating of the most promising directions of robotics development at the mo-ment is proposed, depending on the current market situation affected by unstable economic factors. The ad-vantage of the considered methodology is that, firstly, a relevant-processed array of data regularly published in the annual statistical collections of IFR - World Robotics is used as the basis of the analysis, secondly, the availability of varying preferences of factors affecting the economic situation, and, thirdly– simplicity. The results obtained can be used by interested organizations both for the development of conceptual documents on the development of robot-ics, and for the development of proposals for the initiation of commercial projects.
Approach to the study of AUV control algorithms in the event of faults in its equipment
Authors:   JSC Concern Central Research Institute Elektropribor, Martynova Lyubov , Pashkevich Ivan ,   JSC Concern Central Research Institute Elektropribor, Podshivalov Georgy ,   JSC Concern Central Research Institute Elektropribor, Konyukhov Gennady ,   JSC Concern Central Research Institute Elektropribor, Gorbachev Nikolai ,   JSC Concern Central Research Institute Elektropribor, Grinenkova Tatyana ,   JSC Concern Central Research Institute Elektropribor, Starikov Alexander ,   JSC Concern Central Research Institute Elektropribor
Published: September 2023

The stand for modeling the functioning of subsystems of an autonomous underwater vehicle and its control system is considered, the possibility of testing algorithms in the event of malfunctions in the equipment is analyzed - with-out interfering with the regular operation of algorithms placed in the form of programs on the standard hardware. An approach is proposed for conducting research related to the occurrence of malfunctions in the equipment of the subsystems of the apparatus and aimed at testing the operation of the algorithms for the functioning of the subsys-tems of the apparatus and its control system. The approach is based on the formation of a database of possible faults for each subsystem of the device and the device as a whole, the development of an algorithm for the ran-dom occurrence of faults of one of the types from the database of faults. An operator's workstation has been de-veloped with an interface for the fault setting program, which provides for the fault setting both by the operator and by the probabilistic program at random times. The interface allows you to visually display service information about the current consumption, energy consumption and heat generation of each of the subsystems, transfer this data to the software simulator of the power generation and distribution subsystem to assess the load of the power supply system and power sources. Protocols for setting simulation modes have been developed that do not affect the ex-change of information using standard protocols for information and technical interaction. The behavior of the ap-paratus in the event of malfunctions has been studied. The results of testing the developed fault simulation algo-rithms and protocols for setting simulation modes showed the correctness of the proposed approach; the results were implemented in the existing stand for modeling the functioning of the apparatus. The developed algorithms and protocols for setting simulation modes, their implementation in the form of software made it possible to carry out large-scale numerical experiments on the bench for simulating the operation of the apparatus to develop algo-rithms and programs not only in normal modes of their operation, but also in the event of malfunctions.
The Role of Anti- Cathapsin G among Patients with Rheumatiod Arthritis
Authors: Al-Rubaye Mahmood R. , Abdul-Qader Sajid N. , Abdul–majeed Nahla G. , Kamil Leen K. M.
Published: September 2023

Background: Perinuclear Antineutrophil Cytoplasmic Autoantibodies (pANCA) have been found in patients with rheumatiod arthritis. Cathepsin G was the major target antigen.The present study was to investigate the unknown target antigen of ANCA (Cathapsin G ) in patients with rheumatiod arthritis Objective: This study is to investigate the prevalence of anti-Cathapsin G and rheumatoid factor in Iraqi patients with rheumatiod arthritis.Patienties&Methods: From1st January until 30 June of 2011 fourty five rheumatiod arthritis patients referred to the immunological department in the teaching laboratory of medical city and twenty five apparently healthy individual used as a control group were investeged to rheumatic factor IgG, IgM ,IgA isotypes and anti-Cathapsin G were measured by using enzyme immunoassay technique.Result: This study showed that the age of patients with rheumatiod arthritis ranged between eigthen years and sixty six years with mean age of (36.08) , while the mean level for RF screen, RF IgG, RF IgM, RF IgA isotypes and anti-Cathapsin G were (160.71, 91.7, 136.64, 95.03 and > 9.2 ) respectively. There were 17(37.8%) males and 28(62.2%) females of RA patients. Immunologically, this study revealed that the serum RF screen was found more than 25 U/ml in all rheumatiod arthritis patients (100%, P: 0.0001 HS). On the other hand RF isotypes IgG ,RF IgM and IgA level were elevated more than 20 U/ml and it was detected in 31 (68.9%, P: 0.0001 HS), 31 (68.9%, P : 0.0001 HS) ,and 32 (71.1%, P: 0.0001 HS) patients respectively, while the rheumatiod factors (IgG,IgM, and IgA)were normal in healthy control group . Statistically RF screen has a highly significant association with RF IgG, IgM, and IgA (P= 0.0001). Anti-Cathapsin G was found in 12(26.7%, P value: 0.019) of patients with rheumatic arthritis patients. This study showed a association between the positive result of anti-Cathapsin G with RF IgG and RF IgM (35.5%, P: 0.047) the results were the same for both, while no association found with RF IgA (25%, P: 0.692).Conclusion: A significant correlation was found between anti-Cathapsin G and patients with rheumatiod arthritis and has a significant association with RF IgG and RF IgM while RF IgA had no relation with anti-Cathapsin G.
The levels of IFN- , IL-12 And Testosterone Hormone in Persons with Asymptomatic Toxoplasmosis
Authors: Abdul-Lateef Huda I. , AL-Najar Sabah A. , Abul Majeed Nahla G.
Published: September 2023

Background: The primary goal of this study is to perceive the immunological differences in mean level of IFN- and IL-12 in persons who have positive results for anti-toxoplasma gondii antibodies compared to persons who gave negative results for these antibodies. The secondary goal is to inspect the endocrineimmune interaction in thesepersons by detecting the effect of testosterone hormone level on cellular immune response namely, IL-12& IFN- . This study also detect the effect of Toxoplasma gondii on the level of testosterone hormone in those persons compared with healthy control.Objective: Investigate the relationship between T. gondii and serum IL-12,IFN- and testosterone hormone levels in asymptomatic persons with positive anti-toxoplasma antibodies compared with healthy control and Study the endocrine _immune interaction in these persons .Patients and methods: Seventy seven asymptomatic persons who have positive anti-toxoplasma antibodies and 30 persons who have negative anti-toxoplasma antibodies were included in this study and subjected to estimating the levels of IL-12, IFN- and testosterone hormone by ELISA technique.Results: The levels of both IL-12 and IFN- were statistically higher in persons with positive antitoxoplasma antibodies than in control. The levels of testosterone hormone were higher in both males and females with positive toxoplasmosis than control. There was a positive association between increased level of testosterone and IL-12 level while there was no effectiveness of testosterone on IFN- level in persons with positive anti-toxoplasma antibodies.Conclusion: Toxoplasma gondii elicits cellular immune response detected by statistically important increased in IL-12 and IFN- level compared with control. Not only host hormone can affect responses to infection, but parasites can both enhance production and alter hormone concentration in their hosts.
Profesor Profesorów. Laudacja wygłoszona dla ks. Profesora Józefa Krukowskiego z okazji wręczenia Nagrody imienia Księdza Idziego Radziszewskiego. Lublin, KUL, 16 maja 2012 r.
Authors: Sitarz Mirosław
Published: September 2023

Zarząd Towarzystwa Naukowego Katolickiego Uniwersytetu Lubelskiego Jana Pawła II najwybitniejszym osobistościom ze świata nauki w dowód uznania „za całokształt dorobku naukowego w duchu humanizmu chrześcijańskiego” przyznaje NAGRODĘ IMIENIA KSIĘDZA IDZIEGO RADZISZEWSKIEGO.
Prawo Unii Europejskiej a wartości chrześcijańskie
Authors: Krukowski Józef
Published: September 2023

The Author explained the term of the law and the term of the values, especially Christian values. In the article, the Author distinguished two categories of the Christian values: 1) peculiar Christian values based on the theological grounds singling out religion and Christian ethic. The Church regulates the means of the achievement of these values with the assistance of the canon law; 2) universal ethical principles, which are basic human values, such as respect for the hierarchy of values, recognition that human being is in the first place in that hierarchy and recognition that the natural human dignity is a source of the fundamental rights and freedoms. The law of the European Union refers to the values. Politicians of the European Union have made the project of building the community called “European civil society”. Christians as the citizens of the European Union, should not be just passive observers while basic universal Christian values are disregarded. They should demand from politicians to respect the principle of the common good.
Od “tradit et acceptat ius in corpus” do “sese mutuo tradunt et accipiunt”. Ewolucja w ujęciu istotnego przedmiotu zgody małżeńskiej
Authors: Góralski Wojciech
Published: September 2023

In the article, the Author showed the evolution – from the Code of Canon Law of 1917 to the Code of Canon Law of 1983 – of the essential subject of the matrimonial consent. In the Code of Canon Law of 1917 there was biology conception of the marriage. According to the can. 1081 § 2, an essential subject of this consent are acceptance and transmission “ius in corpus”. Therefore, the material subject was the undying and the sole right to the body of the spouse, while the formal subject was sexual intercourse. According to the teaching of the Vatican Council II, marriage is a community of life and love conjugal. What is more, marriage is not only for the procreation and education of offspring, but also for the good of the spouses. Consequently, the phrase “ius in corpus” has been removed from the Cod e o f Canon Law of 1983.
Sprawozdanie z XIV Międzynarodowego Kongresu Prawa Kanonicznego Administracja w prawie kanonicznym. Warszawa, 14-18 września 2011 r.
Authors: Słowikowska Anna
Published: September 2023

„Administracja w prawie kanonicznym” – pod takim hasłem odbywał się w dniach 14-18 września 2011 r. XIV Międzynarodowy Kongres Prawa Kanonicznego zorganizowany przez Wydział Prawa Kanonicznego Uniwersytetu Kardynała Stefana Wyszyńskiego w Warszawie pod przewodnictwem prof. J. Wroceńskiego – Dziekana WPK przy współudziale Międzynarodowego Stowarzyszenia Prawa Kanonicznego (Consociatio lnternationalis Studio luris Canonici Promovendo, Rzym) na czele z prof. P. Valdrinim – Przewodniczącym Consociatio.
Study on Laser Cladding Remanufacturing of 30Cr Drive Shaft for Electric Machine
Authors: Chen Zhiquan , Chu Xuyang , Ji Dongshen , Shen Zheng , Lin Jinming
Published: September 2023

In response to the crack failure of a drive shaft of a type of motor subjected to high torque after a long period of overload operation, a remanufacturing study was conducted using laser cladding technology. In this paper, the remanufactured material was designed from the material composition of the motor drive shaft and the processing parameters were optimized. The results show that the Ni-Cr alloy powder was selected as the cladding material, and a cladding layer with good bonding properties, Excellent macroscopic morphology and mechanical properties were fabricated on the 30Cr alloy substrate via laser cladding technology under the parameters of laser power 2400 W, sweep speed 16 mm/s and powder feed rate 16 g/min., which can effectively extend the life of this motor drive shaft. The life of the motor drive shaft was effectively extended. The remanufacturing of the motor drive shaft not only saves resources but also improves the operation and maintenance efficiency of the motor.
Digital Twin Modeling of a Five-Axis Linkage Crossbeam Mobile Gantry Milling Machine
Authors: Wu Changjun , Tao Tao , Wang Qiaohua , Wang Liangwen , Zhao Piaoyang , Zhang Yiling
Published: September 2023

In the innovative design stage of machine tool (MT), in order to understand the motion status of the MT under different conditions, shorten the development cycle, and improve machining accuracy, this paper proposes a digital twin modeling method for large crossbeam mobile gantry milling machines. By combining digital twin technology, the selection of MT motion components and the design of various motion mechanisms were completed, as well as the machining scheme design of the MT bed. Modeling and simulation were conducted to complete the workpiece machining function, By using digital twin technology to virtually simulate CNC MT and verify their properties in physical prototypes, new ideas are provided for the application of digital twin technology in the design process of CNC MT.
Kinematics Analysis of Main Transmission Mechanism of Double Servo Drive Press Based on Rigid-Flexible Coupling
Authors: Yang Zhenguo , Song Yanli , Lu Jue , Fang Zhiling , Yan Jianwen
Published: September 2023

In this paper, the main transmission mechanism of the double servo drive symmetrical toggle press was taken as the object of study. The theoretical derivation of its motion characteristics was carried out. A parametric model was established to analyze its rigid body kinematics. The kinematic performance was improved by rigid-flexible coupling. The research results could provide an important reference for the development of large-tonnage wide-table double servo drive press.
Research on the Manufacturing Technology of the Main Steel Frame of Sanming Shaxian Airport Terminal
Authors: Feng Zhengwei , Lin Longbin , Shen Yaohui
Published: September 2023

This paper is based on the main steel structural engineering project of Sanming Shaxian Airport Terminal. The lobby of the terminal building is mainly composed of box shaped components and BH shaped steel beams. Purlins and supports are made of H-shaped steel or circular pipes and other components. There are 13 steel roof trusses located directly on reinforced concrete columns in the corridor, and each roof truss is connected by box type roof joists. This article mainly introduces the manufacturing process, assembly, and welding process of box shaped steel frame components for the main steel frame of the terminal building. It analyzes the processing and welding methods of box columns, and proposes corresponding quality control points for assembly accuracy and welding quality. It solves difficult problems such as welding and deformation control of I-shaped members, ensures the smooth progress of the project, and provides reference and reference for the manufacturing of steel box beams in similar projects.
A Most Unfavorable Active Earth Pressure Method Considering Stability Tests for Retaining Wall
Authors: Liang Yao , Chen Wensheng
Published: September 2023

Earth pressure is a critical foundation for retaining wall design and verification, but in the earth pressure calculation, the geometrical parameters of the retaining wall itself are not taken into account in the tests of the stability of the retaining wall. In order to obtain a more complete method for calculating retaining walls, this paper analyses the forces between the soil behind the wall and the retaining wall and shows that when calculating the Coulomb earth pressure, the earth pressure behind the wall only needs to stay within the limit state. The direction of the earth pressure can therefore only vary within a defined range of angles and there exists a direction of earth pressure which is the most unfavourable for the retaining wall out of many. this paper proposes a mechanical model for the most unfavourable active earth pressure in retaining wall design and derives a calculation formula; the calculation example proves that the calculation results are significantly different from Coulomb’s theory and the resulting earth pressure makes the retaining wall less stable during the verification.
Study on the Influence of Circumferential Slit Charge on Blasting Fragmentation
Authors: Zhang Qingbin , Wan Shen , Huang Yinhong , Yan Tiancheng , Liu Baoxu , Liu Gongjian
Published: September 2023

In view of the problems that the tunnel constructed by drilling and blasting method is prone to large blocks, the low utilization rate of explosive energy, and large peak value of structural vibration during blasting, the model tests of circumferential slit charge and conventional blasting are carried out using standard concrete test blocks of 40 MPa, 50 MPa, and 60 MPa. The test result shows that with the same amount of explosives, the average block size and block rate obtained from circumferential slit blasting is lower, compared to conventional blasting, the average block size of circumferential slit blasting can be reduced by 3 mm to 15 mm, and the block rate can be reduced by 5.21% to 27.44%, with a more optimal distribution of explosive energy. In terms of blast pressure distribution, the circumferential slit package has an obvious phenomenon of energy concentration after detonation, while the blast pressure around the hole wall is more evenly distributed during conventional blasting, and the blast pressure at the slit is 0.62 GPa greater than that of conventional blasting. Circumferential slit charge blasting technology offers new way for improving blasting fragmentation in tunnel engineering.
Research on Prediction Model of Ground Settlement for Ultra-Large Diameter Double-Line Shield Tunnel
Authors: Liu Baoxu , Zhang Qingbin , Huang Yinhong , Wang Sheng , Xue Yongwang
Published: September 2023

The construction of double-line parallel tunnels causes significantly more surface settlement than single-track tunnels. To accurately forecast the surface settlement brought forth by the building of extremely large diameter double-track parallel shield tunnels, by introducing the correction coefficient M(x) of the formation loss rate, a model of prediction for the surface settling of super-large diameter double-line parallel tunnels is created in accordance with the Peck formula. And validate the prediction method based on a mega-diameter shield Project in Changsha. The results indicate that the double disturbance effect will cause obvious additional settlement. When considering its influence, the location of the maximum surface settlement of soil on the backward tunnel side is shifted by 2.28 m towards the advance tunnel, causing the settling curve on the backward tunnel and the overall surface settling curve to be distributed asymmetrically; Soils on the advance tunnel side are more sensitive to secondary disturbance effects; The prediction model applies to the surface settlement prediction of the super-large diameter double-line shield project in Changsha area, and the study’s findings can serve as suggestions for undertakings of a similar nature.
Application of Anchor-Grouted Static Pressure Pile and Soil Excavation Correction in House Correction
Authors: Chen Wei , Xiao Ping , Tan Qizhou
Published: September 2023

The combination of anchor-pile static-pressure pile and soil excavation correction has been widely used in modern building settlement correction projects due to its significant effect and good economy. Its working principle is to use the anchor-pile static-pressure pile method to effectively reinforce the building foundation. After the pile pressing is completed, a pressure-locked temporary pile is placed on the side with larger settlement to achieve rapid settlement prevention. Then, the soil excavation correction is carried out on the side with smaller settlement of the building by reducing the contact area between the original friction pile at the bottom of the foundation and the soil, reducing the bearing capacity of the foundation, and accelerating the settlement of the side with smaller settlement, thus achieving the correction effect. This paper introduces the case of settlement correction and reinforcement of residential buildings in a certain community in Yangzhou City, Jiangsu Province. By sorting out the settlement and tilt observation data provided by third-party testing units, the original geological survey report and supplementary survey report, and the original building structural drawings and other materials, the reasons for the building’s settlement exceeding the standard limit and uneven settlement are analyzed. The selection of the correction and reinforcement scheme, specific parameter values, construction sequence, dynamic monitoring during the correction process, the actual layout of the anchor-pile static-pressure pile, the arrangement of soil excavation holes, the settlement rate and tilt of the building after settlement correction, can provide some reference and engineering experience for similar projects.
Total quality management and sustainable policy making strategies in biochemical industries: A critical review of prior research
Authors: Rakte Jijabai B. , Nanda Satyajeet , Dateer Ramesh B.
Published: September 2023

BACKGROUND: The history of Total Quality Management (TQM) presents a broad overview of the processes used to make things perfect in this imperfect world. The concept of TQM strategy in biochemical industries highlightsnumerous ways to use “quality” as a tool for improvement in the real work environment during the actual execution of work. A sustainable and effective quality management policy with specific missions and objectives mightlead to the achievement of a productive outcome in biochemical industry. OBJECTIVE: This study focused to examine the variation in understanding of TQM in the biochemical Industry and its correlation with other aspects of organizational improvement. To study the impact of TQM on a sustainability aspects of biochemical organizations by framing an appropriate synthetic model. METHODS: The strategic to setup a ‘hard’ and ‘soft’ TQM principles was used for effective TQM implementation. In addition, individually developed methods of TQM quality award models were implemented in a wide range of industries. RESULTS: This study reveals that, a significant number of biochemical industries recognize that sustainable business strategies and successful implementation of TQM practices lead to new opportunities and improves results in the economical and sustainable development. CONCLUSION: Appropriate policy-making strategies and TQM are critically important ingredient for organizational growth. The implementation of TQM in biochemical industries is important for the overall growth of the organization and employees.
Advanced Alzheimer’s Disease Patients Show Safe, Significant, and Persistent Benefit in 6-Month Bryostatin Trial
Authors: Alkon Daniel L. , Sun Miao-Kun , Tuchman Alan J. , Thompson Richard E.
Published: September 2023

Background: In pre-clinical studies, Bryostatin, MW (molecular weight) 904, has demonstrated synaptogenic, anti-apoptotic, anti-amyloid, and anti-tau tangle efficacies. Objective: To identify AD patients who show significant cognitive benefit versus placebo when treated in a trial with chronic Bryostatin dosing. Methods: In this 6-month 122 AD patient Bryostatin trial, there were two cohorts: the Moderate Cohort (MMSE, Mini-Mental Status Exam: 15-18) and the Moderately Severe Cohort (MMSE 10-14) as pre-specified secondary endpoints. Patient randomization was stratified by baseline SIB to insure balance in baseline cognitive ability between treatment arms. Results: With no safety events noted by the data safety and monitoring board, the Moderately Severe (MMSE 10-14) Bryostatin-treated patients were significantly improved above the placebo patients for Weeks #13 through Week #42. After two cycles of 7 x i.v. Bryostatin doses over a 26-week period, the 10-14 Cohort Severe Impairment Battery (SIB), measured every 2 weeks, showed significant benefit using a Mixed Model Repeated Measures model (MMRM, 2-tailed, p < 0.05) for Weeks #13 through #42, even 16 weeks after dosing completion by Week #26. Placebo 10-14 patients showed no benefit, declining to negative 12.8 points by Week #42. Trend analyses confirmed the MMRM data for this Cohort, with a significant downward slope (equivalent to Cognitive Decline) for the placebo group, p < 0.001, 2-tailed, but no significant decline for the Bryostatin-treated group (p = 0.409, NS), treatment versus placebo p < 0.007. The Moderate Cohort patients showed no significant benefit. Conclusions: The Bryostatin-treated MMSE 10-14 patients showed no significant cognitive decline throughout the 10-month trial, versus placebo patients’ decline of -12.8 SIB points.
Examine the association of nutrients, lifestyle, and related factors with the risk of depression in a well-nourished over-55-years old community
Authors: Shadmand Foumani Moghadam Mohammad Reza , Etemadi Sharif , Amushahi Mohammad , Araste Asie , Rashidipour Mina , Bakhshipour Reyhane , Jandari Sajedeh , Pezeshki Parnian , Rezvani Reza , Hosseini Zohreh
Published: September 2023

BACKGROUND:

The older adult population is increasing, and depression is commonly observed within this community.

OBJECTIVE:

Examine the association of nutrients and lifestyle with depression in a well-nourished over-55-years old community.

METHOD:

The risk of depression was evaluated by the Beck Depression Inventory. Lifestyle, health-related quality of life, and physical activity were assessed. Dietary nutrient intake was recorded and adjusted to body weight.

RESULT:

58% of the population had mild to severe depression. The differences between depression groups for age, gender, quality of life, and nearly all social-economic factors were significant. The impact of age, physical activity, sports, economic level, and smoking on depression was independent of all other factors. Most adjusted nutrients and energy intake were inversely associated with depression (protein ( p = 0.043), fiber ( p = 0.037), iron ( p = 0.041), vitamin B6 ( p = 0.011), and caffeine ( p = 0.009) was independent of the energy intake). The predictor decision tree model for depression showed working in males and having sport, economics, and living with someone in females were the main depression predictors.

CONCLUSION:

Working for males and sports in females along with a high-quality lifestyle with a diet rich in protein, fibre, iron, vitamin B6, and caffeine were associated with a lower risk of depression in this population.
Features of the numerical modeling of the hydrogeological conditions of the soil massive during the excavation of the pit in the Plaxis software complex
Authors: Khoronzhevskyi Maksym , Miatko Maksym
Published: September 2023

The construction of multi-storey civilian buildings, especially in the central districts of cities, is often accompanied by a developed underground part, which requires deep pits. The construction of such pits often leads to a change in the hydrogeological condition at and near the construction site.

This paper presents a comparison of the stress-strain state of the " base - pit enclosure" system, depending on the method of modeling hydrogeological conditions.

The study is divided into two stages: determination of the main features of the Plaxis software complex toolkit for modeling and determining pore water pressures; creating of numerical models and performing calculations. . The first part of the study describes the basic principle of determining stresses in saturated soils, pore pressure calculation types, hydraulic boundary conditions, and types of soil drainage.

In the second part of the study, the numerical models were developed in Plaxis 2D, based on the real object and hydrogeological conditions at the construction site. The two most popular methods for modeling hydrogeological conditions during dry excavation in the pit are described. A step-by-step calculation is performed taking into account the stages of excavation in the pit and dewatering and the construction of retaining structures according to the scheme provided by the design solutions.

The results of the calculations demonstrate the difference in the obtained values of forces and horizontal displacements of the retaining wall for models created using different methods of setting the hydrogeological conditions of the base.

In order to improve the accuracy of calculations and determine the impact of soil permeability, the impact of the stratigraphy of the base was excluded by solving theoretical problems with a homogeneous soil massif composed of clay or sandy soil with groundwater filtration rates in a wide range (kx=ky=0.001...6m/day). Based on the results obtained, it was found that both methods correlate with each other in the case of the presence of poorly filtering soils with a filtration coefficient of k=0.001...0.05 m/day, the calculations demonstrated similarity in the displacements and forces of the retaining wall in such schemes up to 97.9-99.9%. Instead, in the case of soils with high water permeability (k=0.4...6 m/day), the difference in results is up to 56.5%.
The practice of arranging a pit deeper than the level of the soles of the foundations of the surrounding buildings
Authors: Vynnykov Yuriy , Akopian Mkrtich
Published: September 2023

A rational constructive-technological decision to arrange a fence of a deeper pit for a new building than the depth of laying strip foundations of the surrounding buildings has been substantiated and tested in practice. The decision to arrange the fence was tested based on the results of complex experimental and theoretical studies under the conditions of a wet loess massif. At same time, regulatory restrictions on additional subsidence  of these buildings foundations are provided. It has been proven that the additional subsidence of existing objects did not exceed the permissible values according to the norms. This happened due to the arrangement of the pit fence, the phasing of soil extraction in the initial stages under of the soil berm protection. The technology provided for the construction of a pit fence with sheet piling (I-beam No. 30) with a step of 1 m, with timber lagging between them. Then they installed the capping beam, struts, rakers and gradually raised the floor and outer wall of the parking lot of the new building.

The results of long-term geodetic observations  of the foundations deformations of buildings located in the zone of the pit  influence of the new building at various construction stages  of its enclosure are described.

Sufficient convergence of the simulation results in the plane condition using the FEM and field studies was determined (the relative error did not exceed 20%). An elastic-plastic soil model of the "basement - foundations of an existing building - pit enclosure" system was used for modeling.

The article describes examples of the results of FEM modeling of soil massif  deformations  at various stages of pit fence construction.

It was determined that during construction the largest horizontal movements of the pit fence vary from 8 to 23 mm in the area of existing buildings.The maximum vertical movements of the bases foundations  of these buildings amounted to 10 mm, which does not exceed the permissible values according to the norms.

Prospects for further research on assessing the level of reliability of the pit enclosure by determining the variability parameters of the components of the system "foundation - foundation of the existing building - pit enclosure" have been determined.
Evaluation of the influence of the pile cap’s spatial rigidity on the stress-strain state of pile foundations of the building
Authors: Zhuk Veronika , Aloshkina Oleksandra , Piatkov Oleksandr
Published: September 2023

Providing citizens with housing is one of the urgent problems in Ukraine. The limited number of floors allows the use of such an architectural and planning solution for open-type city blocks (internal areas with such planning remain more open and transparent, create a feeling of free space). In order to solve this problem, first of all, it is necessary to make structurally correct and economically reasonable solutions at the stage of building design, because 60...70% of the building price is the cost of structures and materials.

The main task of the designer is to develop structures for the safe and efficient operation of the building. These factors depend on the correctness of the development of the structural scheme of the building and the correctness of the calculation. The development of modern technologies and the availability of various calculation software complexes make it possible to perform such calculations. They make it possible to take into account the interaction of the elements of the "soil base – foundation - above-ground structures" system, which is mandatory for a modern level of design.

Computer modeling with the use of various software complexes allows us to monitor the formation of the stress-strain state in the load-bearing structures of the building depending on the deformation properties of the soil base on the construction site, also depending on the change in the parameters of the structures of the building itself. A comprehensive analysis of the initial data, a detailed study and analysis of the engineering and geological conditions of the construction site, taking into account the planning and construction scheme of the building, as well as performing a complex numerical study of the stress-strain state of the building elements allows to monitor the influence of changes in the parameters of the foundations on the redistribution of deformations and stresses in all structural elements of the building. Therefore, performing computer simulation makes it possible to choose a rational type of foundations that will have not only reliability requirements, but will also be cost-effective at the same time.

This article presents the results of a comparison of the options of a raft pile cap and a strip pile cap of the foundations on the stress-strain state of the foundation structures. The conducted research confirms that the transition from the strip pile cap option to the raft pile cap option causes a change in the subsidence character of the building. It is shown that the use of variable design of foundations makes it possible to design a reliable and at the same time cost-effective option of foundations. Based on the results of the study, the choice of a rational option of foundations was substantiated.
Феномен декаплінгу як важлива умова організації сталого розвитку національної системи освіти
Authors: Пушкарьова Тамара
Published: September 2023

У представленій до обговорення науковцями та практиками статті надано тлумачення феномену декаплінгу. Наведено узагальнене визначення означеного явища та специфічні особливості його проявів у структурній розбудові сучасної української школи. Обговорено методологічну відповідність залучення поняття «декаплінг» до категоріального апарату педагогічноїнауки та охарактеризовано коло організаційних і методичних питань, які є дотичними до проявівдекаплінг ефекту під час провадження освітньої діяльності. Проаналізовано результативні ознаки, що супроводжують прояви декаплінгу в умовах реформування системи національної освіти,в аспекті узгодження, з одного боку, якісного рівня послуг, а з іншого боку, кількісного заощадження ресурсів, які задіяні у функціонально-організаційнійконструкції освітньої галузі.