bluuebunny/crossref_metadata_2025 huggingface dataset:
Hydrogen atom transfer in the radical cations of tryptophan-containing peptides AW and WA studied by mass spectrometry, infrared multiple-photon dissociation spectroscopy, and theoretical calculations
Authors: Piatkivskyi Andrii , Lau Justin Kai-Chi , Berden Giel , Oomens Jos , Hopkinson Alan C , Siu KW Michael , Ryzhov Victor
Published: October 2018

Two types of radical cations of tryptophan—the π-radical cation and the protonated tryptophan-N radical—have been studied in dipeptides AW and WA. The π-radical cation produced by removal of an electron during collision-induced dissociation of a ternary Cu(II) complex was only observed for the AW peptide. In the case of WA, only the ion corresponding to the loss of ammonia, [WA–NH3] •+, was observed from the copper complex. Both protonated tryptophan-N radicals were produced by N-nitrosylation of the neutral peptides followed by transfer to the gas phase via electrospray ionization and subsequent collision-induced dissociation. The regiospecifically formed N• species were characterized by infrared multiple-photon dissociation spectroscopy which revealed that the WA tryptophan-N• radical remains the nitrogen radical, while the AW nitrogen radical rearranges into the π-radical cation. These findings are supported by the density functional theory calculations that suggest a relatively high barrier for the radical rearrangement (N• to π) in WA (156.3 kJ mol−1) and a very low barrier in AW (6.1 kJ mol−1). The facile hydrogen atom migration in the AW system is also supported by the collision-induced dissociation of the tryptophan-N radical species that produces fragments characteristic of the tryptophan π-radical cation. Gas-phase ion–molecule reactions with n-propyl thiol have also been used to differentiate between the π-radical cations (react by hydrogen abstraction) and the tryptophan-N• species (unreactive) of AW.
Structure–property relationship and controlled drug release from multiphasic electrospun carvacrol-embedded polylactic acid/polyethylene glycol and polylactic acid/polyethylene oxide nanofiber mats
Authors: Scaffaro Roberto , Gulino Fortunato Emmanuel , Lopresti Francesco
Published: October 2018

Electrospinning technologies gained considerable interest over the last decade. In this study, it is proposed a systematic study of polylactic acid/polyethylene glycol (PLA/PEG) and polylactic acid/polyethylene oxide (PLA/PEO) electrospun blends at different concentrations. The effect of blend composition and PEG molecular weight on the morphological and mechanical properties of the mats was evaluated. Furthermore, the kinetic release of carvacrol as model drug in phosphate buffer saline at 37℃ was studied and the data were then fitted using an exponential model. The scanning electron microscopy revealed that the morphology of the mats was strongly dependent on the relative ratio PLA:PEG, PLA:PEO and in the presence of carvacrol. Furthermore, the mechanical properties of the mats as well as their carvacrol release rate were successfully tuned by changing the relative ratio of the blend components.
Effects of a fatiguing run in popliteal vein flow using sports compression socks
Authors: Oficial-Casado FJ , Aparicio I , Julian-Rochina I , Blanes M , Perez-Soriano P
Published: October 2018

Introduction

Although the use of sports compression socks is becoming more popular, there is still a lack of knowledge regarding the helpfulness of these garments for physical movement or sports use. One of the main effects attributed to the use of compression sock is the facilitation of venous blood flow return which is thought to improve performance and recovery.

Methodology

In this study, 10 trained runners performed 2 treadmill running tests for 30 min to 75% of their maximum aerobic speed, without sports socks (control) and with different sports compression socks. We measured popliteal vein flow volume before and after each test using magnetic resonance imaging.

Results and discussion

No differences were observed between the conditions before the test ( p > 0.05), but there were differences between the high compression socks condition and the control after the test ( p < 0.05). Exercise increased the venous flow in both legs in the control ( p < 0.001) as well as in the right leg with the high compression sock type ( p < 0.01) but there were no differences in the behaviour of the different sock compression levels ( p > 0.05).

Conclusion

The use of sports compression socks with different levels of compression does not increase the volume of venous blood return via the popliteal vein in trained athletes after running for 30 min.
Intervention-Induced Motor Cortex Plasticity in Hemiparetic Children With Perinatal Stroke
Authors: Kuo Hsing-Ching , Zewdie Ephrem , Ciechanski Patrick , Damji Omar , Kirton Adam
Published: October 2018

Background. Clinical trials are suggesting efficacy of intensive therapy combined with brain stimulation to improve hand function in hemiparetic children with perinatal stroke. However, individual variability exists and the underlying neuroplasticity mechanisms are unknown. Exploring primary motor cortex (M1) neurophysiology, and how it changes with such interventions, may provide valuable biomarkers for advancing personalized neurorehabilitation. Methods. Forty-five children (age 6-19 years) with hemiparesis participated in PLASTIC CHAMPS, a blinded, sham-controlled, factorial clinical trial. All received 80 hours of goal-directed intensive upper extremity therapy. They were randomized into 4 groups: repetitive transcranial magnetic stimulation (rTMS) of contralesional M1, constraint therapy, both, or neither. Stimulus recruitment curves (SRC), short-interval intracortical inhibition (SICI), and intracortical facilitation (ICF) for lesioned and contralesional M1 were investigated using TMS. Clinical assessments including the Assisting Hand Assessment (AHA) and Canadian Occupational Performance Measure (COPM) were conducted pre- and postintervention. Results. All children completed the intervention and both function (AHA) and goal performance (COPM) improved with additive effects of rTMS and constraint ( P < .01). After intervention, motor-evoked potential (MEP) amplitudes from the contralesional M1 to the less-affected hand increased (n = 16, P < .02). SRC from the contralesional M1 to the less-affected hand increased (n = 25, P < .01). SICI of the contralesional M1 to the less-affected hand decreased (n = 30, P < .04). No changes were observed for ICF in either hemisphere ( P > .12). Conclusion. TMS applied before/after intensive neuromodulation therapies can explore M1 neurophysiology and plasticity in children with cerebral palsy. Increased MEP sizes and decreased SICI may reflect mechanisms of interventional plasticity and be potential biomarkers of individualized medicine.
Automobile active tilt control based on active suspension
Authors: Yao Jialing , Li Zhihong , Wang Meng , Yao Feifan , Tang Zheng
Published: October 2018

The rolling control of a car that focuses on reducing the roll angle passively has limited performance of increasing handling stability, passing speed, ride comfort, and rollover prevention while turning. This project presents a method for controlling an automobile to tilt toward the turning direction using active suspension. A 6-degree-of-freedom vehicle model with a 2-degree-of-freedom steering model and a 4-degree-of-freedom tilting model is established. The active tilt sliding mode controller, which causes zero steady-state tilt angle error, is established after the desired tilt angle is determined by dynamic analysis. Simulation results confirm the effectiveness of the control method. The proposed controller reduces the perceived lateral acceleration and the lateral load transfer rate, thereby effectively improving handling stability, ride comfort, and vehicle speed, meanwhile decreasing the possibility of rollover while turning.
The research of object tracking filter fault diagnosis method based on reconstruction of feature vector in fractional Fourier transform domain
Authors: Chen Qing-Tang , Huang Yi-Jian , Song Yi-Ran
Published: October 2018

To carry out state identification and fault diagnosis of mechanical equipment, a new method is proposed for fault diagnosis of mechanical equipment based on the reconstruction of feature vector in the fractional Fourier transform domain. First, the time series of vibration signals are performed by fractional Fourier transform in different orders, according to statistical characteristic in the fractional Fourier transform domain. The kurtosis coefficients are then used for searching the optimal order. Next, taking the normal signal as the tracking target, the difference between the detection signal and the normal signal in fractional Fourier transform domain is calculated in the optimal order, so the normal signal is filtered and the state vector is extracted. The characteristic parameters of the correlation dimension, the zero-order moment, and the kurtosis coefficient are then restructured as a feature vector, and finally, the states are recognized using the k-nearest neighbor cross-validation estimation method. The effect of feature extraction is analyzed by correlation coefficient and diagnostic effect is evaluated using the correct rate of diagnosis. Experiment and analysis illustrates that this proposed target tracking filter fault diagnosis method based on reconstruction of feature vector in fractional Fourier transform domain is simple and intuitive. This method has a favorable feature extraction effect, high accuracy rate of diagnosis, high state recognition efficiency, and good recognition stability, making it a viable option for quantitative real-time state recognition and fault diagnosis of mechanical vibration equipment.
Endovascular treatment of proximal para-anastomotic aneurysms after previous surgical repair of infrarenal aortic aneurysms by the chimney technique
Authors: Karaolanis Georgios I , Pipitone Marco Damiano , Torsello Giovanni , Austermann Martin , Donas Konstantinos P
Published: October 2018

Objectives

To evaluate the use of chimney grafts in the treatment of para-anastomotic aneurysms after previous abdominal aortic aneurysms open repair with short neck.

Methods

A retrospective analysis of prospectively collected data of consecutive patients who underwent endovascular repair for proximal aortic para-anastomotic aneurysms following previous open repair for infrarenal abdominal aortic aneurysms was performed. All included patients had a short infrarenal aortic neck (<10 mm) excluding standard endovascular aortic repair. Five patients were symptomatic at the admission needed urgent treatment.

Results

Twelve patients with para-anastomotic aneurysms underwent placement of chimney grafts. The median time between the original operations to redo endovascular procedure was 11 years (interquartile range, 9.5 years). The mean infrarenal length was 4.3 mm (1–9 mm). A total of 28 chimneys grafts were deployed for the 12 patients. The technical success rate was 91.7%. At a median radiologic follow-up of 16 months (2.0–29.4, 95% confidence interval), one patient died, while two late endoleaks and two reinterventions at one and three years for type Ia endoleak were performed by proximal extension and triple chimney graft placement.

Conclusion

The results of the present study show that ch-endovascular aortic repair is a safe technique for patients who suffered from proximal para-anastomotic aneurysms and having short neck unsuitable for standard endovascular repair. Longer follow up warranted to evaluate the durability of ch-endovascular aortic repair for this specific indication.
Prognostic value of pretreatment prognostic nutritional index in non-small cell lung cancer: A systematic review and meta-analysis
Authors: Hu Yuanyuan , Shen Jie , Liu RuiKe , Feng ZhiMei , Zhang ChangNing , Ling Li , Chen LiBo
Published: October 2018

Background:

The pretreatment prognostic nutritional index has been considered a potential prognostic biomarker in patients with non-small cell lung cancer (NSCLC), but this remains controversial. Therefore, we performed a meta-analysis to systematically assess the prognostic value of the prognostic nutritional index in patients with NSCLC.

Methods:

We systematically searched PubMed, EMBASE, Web of Science, and CNKI. The hazard ratios (HRs) with their corresponding 95% confidence intervals (CIs) were used to evaluate the link between the prognostic nutritional index and the oncological outcomes of patients with NSCLC, including overall survival, disease-free survival/recurrence-free survival, and progression-free survival.

Results:

Fifteen studies were included in this meta-analysis. Twelve of these studies explored the association between the prognostic nutritional index and the overall survival of patients with NSCLC. Our pooled analysis indicated that a low prognostic nutritional index was significantly related to adverse overall survival (HR 1.61; 95% CI 1.44, 1.81; P < 0.001). Our results also showed that the prognostic nutritional index was a negative predictor for disease-free survival/recurrence-free survival, and progression-free survival in patients with NSCLC.

Conclusion:

Our meta-analysis demonstrated that there was a close association between the prognostic nutritional index value and prognosis in NSCLC patients and that the prognostic nutritional index may act as a useful prognostic biomarker in NSCLC patients.
The ability to recognise emotions predicts the time-course of sarcasm processing: Evidence from eye movements
Authors: Olkoniemi Henri , Strömberg Viivi , Kaakinen Johanna K
Published: October 2018

A core feature of sarcasm is that there is a discrepancy between the literal meaning of the utterance and the context in which it is presented. This means that a sarcastic statement embedded in a story introduces a break in local coherence. Previous studies have shown that sarcastic statements in written stories often elicit longer processing times than their literal counterparts, possibly reflecting the difficulty of integrating the statement into the story’s context. In the present study, we examined how sarcastic statements are processed when the location of the local coherence break is manipulated by presenting the sarcastic dialogues either before or after contextual information. In total, 60 participants read short text paragraphs containing sarcastic or literal target statements, while their eye movements were recorded. Individual differences in ability to recognise emotions and working memory capacity were measured. The results suggest that longer reading times with sarcastic statements not only reflect local inconsistency but also attempt to resolve the meaning of the sarcastic statement. The ability to recognise emotions was reflected in eye-movement patterns, suggesting that readers who are poor at recognising emotions are slower at categorising the statement as sarcastic. Thus, they need more processing effort to resolve the sarcastic meaning.
Synchronous microsurgical anastomosis in complex replantation surgery
Authors: Wang Szu-Han , Hsu Chung-Chen , Tzou Chieh-Han John , Hu Ching-Hsuan
Published: October 2018

We conducted a retrospective case control study of digital replantations in 16 patients from September 2015 to January 2017. Half of the patients were treated by a synchronous microsurgical technique and the other half underwent conventional micro-anastomoses. The total time for anastomoses, total operation time and survival of digits were the major endpoints in this study. The number of digits replanted and the anastomosis method had significant effects on total anastomosis time. The mean anastomosis time for each digit was 46 min and 70 min in the synchronous and conventional groups, respectively, a 34% reduction in anastomosis time in the synchronous group when compared with the conventional group. Patency rates were 87% (13/15) of all the digits replanted in each group.

Level of evidence: IV
Policing the school: In between dialogues and crime reports
Authors: Lunneblad Johannes , Johansson Thomas
Published: October 2018

The actions and behaviour among students in Swedish schools previously described as teasing, fighting and ‘school trouble’ have gradually come to be positioned and understood within a legal discourse. Self-assessment surveys conducted with students in grade nine, from 1995 onwards, do not, however, reveal any marked increase in violence among young people over time. Consequently, it is possible to identify signification spirals, where certain issues of concern are identified, certain groups of people are targeted, and the issues are gradually multiplied and linked together, leading to an escalation of the threat and a call for firm steps of action. The purpose of the present study was to investigate how different professional groups – school health teams and police officers – related to and understood various measures taken to handle school violence. The authors focused in particular on the increasing tendency to report crimes in schools and the consequences of this trend. The results indicated, on the one hand, an ambivalent attitude towards filing police reports on the part of school health teams. On the other hand, the police officers were highly critical of the reluctance among school health teams to report ‘crimes’ to the police.
Engineering the hard–soft tissue interface with random-to-aligned nanofiber scaffolds
Authors: Nowlin John , Bismi Mehzubh A , Delpech Baptiste , Dumas Patrick , Zhou Yingge , Tan George Z
Published: October 2018

Tendon injuries can be difficult to heal and have high rates of relapse due to stress concentrations caused by scar formation and the sutures used in surgical repair. Regeneration of the tendon/ligament-to-bone interface is critical to provide functional graft integration after injury. The objective of this study is to recreate the tendon-to-bone interface using a gradient scaffold which is fabricated by a one-station electrospinning process. Two cell phenotypes were grown on a poly- ε-caprolactone nanofiber scaffold which possesses a gradual transition from random to aligned nanofiber patterns. We assessed the effects of the polymer concentration, tip-to-collector distance, and electrospinning time on the microfiber diameter and density. Osteosarcoma and fibroblast cells were seeded on the random and aligned sections of scaffolds, respectively. A random-to-aligned cocultured tissue interface which mimicked the native transition in composition of enthesis was created after 96 h culturing. The results showed that the microstructure gradient influenced the cell morphology, tissue topology, and promoted enthesis formation. This study demonstrates a heterogeneous nanofiber scaffold strategy for interfacial tissue regeneration. It provides a potential solution for mimicking transitional interface between distinct tissues, and can be further developed as a heterogeneous cellular composition platform to facilitate the formation of multi-tissue complex systems.
Variable response of post-Mohs surgery telangiectasias to KTP laser: A case report
Authors: Villeneuve-Tang Catherine , Nantel-Battista Mélissa , Richer Vincent
Published: October 2018

A common but under-recognized complication of Mohs micrographic surgery is the development of surgical site telangiectasias after repair. Treatment with pulsed dye laser has shown good results in treating periscar telangiectasias, while treatment with KTP laser has never been studied for this complication. We report the findings in six patients with persistent telangiectasias post-Mohs micrographic surgery and their response to treatment with KTP laser. After one treatment with KTP laser, the severity of telangiectasias, scar erythema, and patient and physician-rated improvement were recorded. Response to KTP laser was variable. However, this case series suggests that KTP laser may have the potential to improve the appearance of periscar telangiectasia after Mohs micrographic surgery.
Acute Kidney Injury Due to Inferior Vena Cava Stenosis After Liver Transplantation: A Case Report About the Importance of Hepatic Vein Doppler Ultrasound and Clinical Assessment
Authors: Beaubien-Souligny William , Pépin Marie-Noëlle , Legault Louis , Cailhier Jean-François , Éthier Jean , Bouchard Louis , Willems Bernard , Denault André Y.
Published: October 2018

Rationale:

Acute kidney injury (AKI) is a frequent complication after liver transplantation. In some patients, prompt intervention targeted at a specific etiology is of paramount importance.

Presenting concerns of the patients:

A 25 years old man with advanced liver cirrhosis caused by sclerosing cholangitis and autoimmune hepatitis underwent orthotopic liver transplantation. One month after surgery, severe AKI developed in conjunction with recurrent ascites and lower extremity edema. Notable clinical findings included a persistently low urinary sodium excretion, a bland urinary sediment, and an abnormally monophasic hepatic vein waveform on Doppler ultrasound.

Diagnoses:

Inferior vena cava stenosis.

Interventions:

Angioplasty with stent installation.

Outcomes:

Rapid improvement of renal function after stent installation.

Lessons learned:

The following case illustrates the importance of integrating clinical cues, ultrasound features, and laboratory findings. The combination of AKI associated with lower extremity edema, abnormal monophasic hepatic vein flow on Doppler ultrasound, and a low urinary sodium excretion after liver transplantation should evoke the possibility of inferior vena cava stenosis as the etiologic factor.
140 Characters of Intoxication: Exploring the Prevalence of Alcohol-Related Tweets and Predicting Their Virality
Authors: Alhabash Saleem , VanDam Courtland , Tan Pang-Ning , Smith Sandi W. , Viken Gregory , Kanver Duygu , Tian Liang , Figueira Luiz
Published: October 2018

Past research has suggested an associative relationship between social media use and alcohol consumption, especially among the younger generations. The current study takes a generalizable approach to examining the prevalence of posting about alcohol on a popular social media platform, Twitter, as well as examining the predictors of a tweet’s virality. We content-analyzed more than 47.5 million tweets that were posted in March 2015 to explore the prevalence of alcohol-related references, and how alcohol-related references, tweet features (e.g., inclusion of hashtags, pictures, etc.), and user characteristics (e.g., number of followers) contribute to the tweet’s virality. Our findings showed that during March 2015, about two of every 100 tweets in the United States were alcohol-related; whereas the majority of those referenced intoxication. In addition to tweet features and user characteristics, the prevalence of alcohol-related references in a tweet positively predicted the number of likes it received, yet negatively predicted the number of retweets. Given prior evidence supporting the association between social media use and alcohol consumption, the prevalence of alcohol references in tweets and how that contributes to their virality offers insights into the widespread phenomenon of glorifying alcohol use and excessive drinking via social media, pointing to potential negative health consequences.
Humanized GPIbα–von Willebrand factor interaction in the mouse
Authors: Kanaji Sachiko , Orje Jennifer N. , Kanaji Taisuke , Kamikubo Yuichi , Morodomi Yosuke , Chen Yunfeng , Zarpellon Alessandro , Eberhardt Jerome , Forli Stefano , Fahs Scot A. , Sood Rashmi , Haberichter Sandra L. , Montgomery Robert R. , Ruggeri Zaverio M.
Published: October 2018

The interaction of platelet glycoprotein Ibα (GPIbα) with von Willebrand factor (VWF) initiates hemostasis after vascular injury and also contributes to pathological thrombosis. GPIbα binding to the VWF A1 domain (VWFA1) is a target for antithrombotic intervention, but attempts to develop pharmacologic inhibitors have been hindered by the lack of animal models because of the species specificity of the interaction. To address this problem, we generated a knockin mouse with Vwf exon 28–encoding domains A1 and A2 replaced by the human homolog (VWFh28). VWFh28 mice (M1HA) were crossbred with a transgenic mouse strain expressing human GPIbα on platelets (mGPIbαnull;hGPIbαTg; H1MA) to generate a new strain (H1HA) with humanized GPIbα-VWFA1 binding. Plasma VWF levels in the latter 3 strains were similar to those of wild-type mice (M1MA). Compared with the strains that had homospecific GPIbα-VWF pairing (M1MA and H1HA), M1HA mice of those with heterospecific pairing had a markedly greater prolongation of tail bleeding time and attenuation of thrombogenesis after injury to the carotid artery than H1MA mice. Measurements of GPIbα-VWFA1 binding affinity by surface plasmon resonance agreed with the extent of observed functional defects. Ristocetin-induced platelet aggregation was similar in H1HA mouse and human platelet-rich plasma, and it was comparably inhibited by monoclonal antibody NMC-4, which is known to block human GPIbα-VWFA1 binding, which also inhibited FeCl3-induced mouse carotid artery thrombosis. Thus, the H1HA mouse strain is a fully humanized model of platelet GPIbα-VWFA1 binding that provides mechanistic and pharmacologic information relevant to human hemostatic and thrombotic disorders.
Comparison of Comorbidity and Frailty Indices in Patients With Head and Neck Cancer Using an Online Tool
Authors: Vitzthum Lucas K. , Feng Christine H. , Noticewala Sonal , Hines Paul J. , Nguyen Cammie , Zakeri Kaveh , Sojourner Elena J. , Shen Hanjie , Mell Loren K.
Published: October 2018

Purpose

Comorbidity is an independent predictor of mortality and treatment tolerance in head and neck cancer and should be considered with regard to treatment intensification. Multiple previously validated models can be used to evaluate comorbidity and propensity to benefit from intensive treatment, but they have not been directly compared.

Materials and Methods

An online tool was developed and used to calculate the Charlson Comorbidity Index (CCI), Adult Comorbidity Evaluation-27 (ACE-27), Cumulative Illness Rating Scale for Geriatrics (CIRS-G), Geriatric 8 (G8), Cancer and Aging Research Group (CARG), and Generalized Competing Event (GCE) scores. To assess interrater variability, five evaluators independently calculated scores on a retrospective cohort of 20 patients. Correlation between models as well as age and performance status were calculated from a cohort of 40 patients.

Results

The GCE and G8 models had an excellent (intraclass correlation coefficient and Fleiss’ kappa ≥ 0.75) degree of interrater agreement. The CCI, ACE-27, CIRS-G, and CARG had a good (intraclass correlation coefficient and Fleiss’ kappa 0.6-0.74) degree of interrater agreement. There was statistically significant correlation between models, especially with the CCI, ACE-27, and CIRS-G indices. Increased age was correlated with an increased CCI score and having moderate to severe comorbidity was correlated with the ACE-27 model. Except for the G8 model, the comorbidity indices were not associated with Eastern Cooperative Oncology Group performance status.

Conclusion

We developed an online tool to calculate indices of comorbidity in patients with head and neck cancer with a high degree of reproducibility. Comorbidity is not strongly correlated with performance status and should be independently evaluated in patients.
Chemotherapy-Free Initial Treatment of Advanced Indolent Lymphoma Has Durable Effect With Low Toxicity: Results From Two Nordic Lymphoma Group Trials With More Than 10 Years of Follow-Up
Authors: Lockmer Sandra , Østenstad Bjørn , Hagberg Hans , Holte Harald , Johansson Ann-Sofie , Wahlin Björn Engelbrekt , Wader Karin Fahl , Steen Chloé Beate , Meyer Peter , Maisenhølder Martin , Smedby Karin Ekström , Brown Peter , Kimby Eva
Published: October 2018

Purpose

For indolent lymphoma, the optimal timing, sequence, and choice of therapeutic regimens remain a matter of debate. In two Nordic Lymphoma Group randomized trials, symptomatic or clearly progressing patients were treated first line with a rituximab-containing regimen without chemotherapy. The purpose of this study was to assess long-term survival, risk of transformation, and need of new therapies.

Methods

Data were collected at cross-sectional follow-up for 321 patients with indolent lymphoma (84% with follicular lymphomas [FL]) included in one of two Nordic Lymphoma Group trials (accrual 1998 to 1999 and 2002 to 2008). All patients received first-line therapy with one or two cycles of four weekly infusions of rituximab 375 mg/m2, and 148 were randomly allocated to the addition of interferon alfa-2a. Follow-up data were retrieved from initial trial databases and medical records on repeated clinical evaluations.

Results

At the end of follow-up, 73% of patients were alive, with a median follow-up after random assignment of 10.6 years. Among all, 36% (38% with FL) had never needed chemotherapy. For patients with FL who required new therapy within 24 months because of early disease progression, the 10-year survival rate was 59% versus 81% for those with longer remission. Interferon was not shown to improve long-term outcome. Transformation was diagnosed in 20% of all patients (2.4% per person-year) and in 18% with FL. An additional malignancy was found in 12%.

Conclusion

Approximately one third of patients with symptomatic indolent lymphoma (30% with FL, 23% without FL) did not need new therapy in the long term after first-line rituximab without chemotherapy. In the entire cohort, 10-year survival was excellent with no major safety issues, which suggests that chemotherapy can be delayed safely in the majority of patients.
Rare variants of the FMN riboswitch class in Clostridium difficile and other bacteria exhibit altered ligand specificity
Authors: Atilho Ruben M. , Perkins Kevin R. , Breaker Ronald R.
Published: October 2018

Many bacteria use flavin mononucleotide (FMN) riboswitches to control the expression of genes responsible for the biosynthesis and transport of this enzyme cofactor or its precursor, riboflavin. Rare variants of FMN riboswitches found in strains of Clostridium difficile and some other bacteria typically control the expression of proteins annotated as transporters, including multidrug efflux pumps. These RNAs no longer recognize FMN, and differ from the original riboswitch consensus sequence at nucleotide positions normally involved in binding of the ribityl and phosphate moieties of the cofactor. Representatives of one of the two variant subtypes were found to bind the FMN precursor riboflavin and the FMN degradation products lumiflavin and lumichrome. Although the biologically relevant ligand sensed by these variant FMN riboswitches remains uncertain, our findings suggest that many strains of C. difficile might use rare riboswitches to sense flavin degradation products and activate transporters for their detoxification.
Species delimitation at a global scale reveals high species richness with complex biogeography and patterns of symbiont association in Peltigera section Peltigera (lichenized Ascomycota: Lecanoromycetes)
Authors: Magain Nicolas , Tniong Camille , Goward Trevor , Niu Dongling , Goffinet Bernard , Sérusiaux Emmanuel , Vitikainen Orvo , Lutzoni François , Miadlikowska Jolanta
Published: October 2018

This comprehensive phylogenetic revision of sections Peltigera and Retifoveatae of the cyanolichen genus Peltigera is based on DNA sequences from more than 500 specimens from five continents. We amplified five loci (nrITS, β‐tubulin and three intergenic spacers part of colinear orthologous regions [COR]) for the mycobiont, and the rbcLX locus for the cyanobacterial partner Nostoc. Phylogenetic inferences (RAxML, BEAST) and species delimitation methods (bGMYC, bPTP, bPP) suggest the presence of 88 species in section Peltigera, including 50 species new to science, hence uncovering a surprisingly high proportion of previously unnoticed biodiversity. The hypervariable region in ITS1 (ITS1‐HR) is a powerful marker to identify species within sections Peltigera and Retifoveatae. Most newly delimited species are restricted to a single biogeographic region, however, up to ten species have a nearly cosmopolitan distribution. The specificity of mycobionts in their association with Nostoc cyanobionts ranges from strict specialists (associate with only one Nostoc phylogroup) to broad generalists (up to eight Nostoc phylogroups uncovered), with widespread species recruiting a broader selection of Nostoc phylogroups than species with limited distributions. In contrast, species from the P. didactyla clade characterized by small thalli and asexual vegetative propagules (soredia) associate with fewer Nostoc phylogroups (i.e., are more specialized) despite their broad distributions, and show significantly higher rates of nucleotide substitutions.
A ANALOGIA NOS PROCESSOS DE MUDANÇA DE VERBOS COGNITIVOS NO PORTUGUÊS BRASILEIRO
Authors: Barbosa Letícia De Almeida , Fortilli Solange De Carvalho
Published: October 2018

Considerando que a analogia é um dos processos cognitivos mais básicos, que consiste na adoção de um modelo para domínios diversos, objetiva-se apresentar uma investigação sobre o papel desempenhado por ela no processo de parentetização dos verbos cognitivos no português. Os verbos cognitivos são os que expressam estados ou atividades que dão origem a percepções, conhecimentos, ideias, crenças ou julgamentos, os quais revelam processos mentais com diferentes nuances de significado. São verbos como pensar, imaginar, supor, deduzir, calcular e outros que, quando parentetizados, revelam a subjetividade do falante funcionando como modalizadores epistêmicos. Neste sentido, a pesquisa toma por base estudos como os de Hopper; Traugott (1993), Martelotta (2010), Tavares (2003) e Fortilli (2013). Para o levantamento e análise de dados, foram selecionados casos encontrados entre os séculos XIX e XX e XXI no Corpus do Português, bem como dados de escrita do século XXI, coletados no jornal Folha.com.
Effects of 8 Weeks of Proprioceptive Training with and Without Taping on Recurrence of Lateral Ankle Sprain in Judokas
Authors: Najafipour Farzad , Babakhani Farideh , Balochi Ramin
Published: October 2018

Taping and proprioceptive training are widely reported beneficial in for treatment of nkle sprains. Several studies reported that the proprioceptive sense training is a potential therapy for improving impaired neuromuscular function.The intention of this article was to evaluate Taping followed by proprioceptive training versus proprioceptive training without taping for Ankle Sprain ecurrence rate. All sprained judokas with acute ankle sprain were advised for standard procedure (ice, rest, elevation, and compression with a compressive bandage). Initially 30 sprained judokas were categorized randomly into two groups and then underwent studies for 8 weeks: one group was treated with tape and proprioceptive training and the other only with proprioceptive training. Both groups were followed up for duration of six month. The study indicated that there is not significant difference between taping and without taping groups. Recurrence rate of acute ankle sprain shows no significant linkage between employment of taping or its absence. Further studies with greater number of participants are suggested.
Biosorptive Removal of Lead (II), Cadmium (II) and Arsenic (III) from Aqua Media on Vigna Unguiculata Leaf Powders
Authors: Akpomie K.G. , Ezeofor C.C. , Eze S.I. , Okey C.N. , Ebiem-Kenechukwu P.I.
Published: October 2018

The biosorption of Cd (II), As (III) and Pb (II) ions from solution utilizing Vigna unguiculata leaf powders (VULP) as a low cost biosorbent was studied. The influence of temperature, metal ion concentration, biosorbent dose, contact time and pH on the sequestration process was examined by batch procedure. Increase in the biosorption of the three metal ions with increased pH and biosorbent dosage was obtained in this study.Equilibrium contact time of 20, 40 and 50min was achieved for Cd(II), As (III) and Pb(II) ions and biosorption was in the order As(III)> Cd(II) >Pb(II). Isotherm analysis was performed by the application of Langmuir, Freundlich, Flory-Huggins and Scatchard models. The Langmuir model gave the best fit with maximum monolayer biosorption capacity of 109.1, 105 and 119.3 mg/g for Cd (II), Pb (II) and As (III) respectively. Scatchard model confirmed a homogenous surface of VULP and monolayer biosorption of metal ions. Pseudo second order model showed the best fit compared to pseudo first order, Elovich and Banghams kinetic models according to kinetic analysis. Thermodynamics study revealed a feasibly, spontaneous exothermic biosorption process. The result showed good potentials of VULP as suitable cheap biosorbent for attenuation of Cd (II), Pb(II) and As (III) ions from polluted wastewaters.
Influence of Linoleic Acid on Quorum Sensing in Proteus mirabilis and Serratia marcescens
Authors: Marathe Kirti , Bundale Sunita , Nashikkar Nandita , Upadhyay Avinash
Published: October 2018

Quorum sensing (QS) is a bacterial cell density dependent mode of communication involved in regulation of virulence in pathogens including biofilm formation. Accordingly, curbing QS might prove to be an anti-virulence approach of controlling nosocomial infections caused by multi drug resistant bacteria. The report presented here documents the QS inhibitory properties of linoleic acid against Proteus mirabilis and Serratia marcescens known to cause nosocomial infections. Urease assay, prodigiosin assay, protease assay, biofilm formation assay and growth curve analysis were performed to investigate the effectiveness of linoleic acid in controlling virulence of P. mirabilis and S. marcescens. 2.5mM linoleic acid reduced the urease activity and biofilm formation to 42.11% and 11.11% respectively in P. mirabilis; and prodigiosin synthesis, protease activity and biofilm formation to 0%, 65.91% and 33.33% correspondingly in S. marcescens. Therefore, analysis of QS inhibitory behaviour of linoleic acid substantiates its use as a plausible drug for anti-virulence therapy without subjecting the bacteria to discerning force of antibiotics.
Genetic Variability, Heritability And Correlation Analysis In Quantitative Traits Of Irrigated Rice (Oryza Sativa L.)
Authors: Acharya Shiva , Shrestha Abhisek , Acharya Narayan , Poudel Ankur , Acharya Suvarna
Published: October 2018

A study was carried out to assess the genetic variability among the genotypes, correlation among traits and heritability of the traits to next generation. Eight rice genotypes were evaluated in Randomized Complete Block Design (RCBD) with three replications during Kharif (June-October) 2017 in experimental field of Lamjung Campus, Sundarbazaar, Lamjung, Western Nepal. The analysis of variance revealed statistically significant differences for all the traits under studied, which showed the presence of genetic variability among the genotypes except ineffective tiller per m2. The higher value of GCV and PCV was recorded for grain per panicle, filled grain per panicle, harvest index and grain yield. The PCV value was observed higher than the GCV value which indicated the influence of environment on the expression of the traits. High heritability along with high genetic advance as percent of mean was observed for grain per panicle, panicle length, harvest index and grain yield. However, high heritability along with moderate genetic advance as percent of mean was observed for days to 50% flowering, 1000 grain weight and plant height. The effective tiller per m2, harvest index,grain per panicle and filled grain per panicle exhibited significant and positive correlation with grain yield. Plant height and ineffective tiller perm2 exhibited negative correlation with grain yield. Grain per panicle, harvest index and grain yield could be suitable traits for selection of the rice genotypes.
Removal of Radium from Uranium Effluent by Manganese Oxide Coated Modified Bentonite (Mn-NaB)
Authors: Abdou Abdou A , Nagar Mohamed S , Ghazala Reda A
Published: October 2018

The results of radiometric analysis show the presence of high level concentration of 226Ra (50 to 125 Bq/L) in the uranium effluent solutions waste of Gattar uranium pilot plant Eastern Desert of Egypt. These levels are higher than the maximum permissible level of 226Ra (1.1Bq/L) which needs treatment. Normally treatment consists of lime addition to increase the pH to 8 which precipitates most contaminants except 226Ra. Adsorption process provides an alternative treatment in comparison with other removal techniques. The sorption of radium (226Ra) on different adsorbent, modified bentonite (Na-B) and a mixture of modified bentonite coated by Manganese oxide (Mn-NaB) was studied. The present study focuses at the option to improve the sorption properties of bentonite via its modification and presents the possibility to remove radium cations from the uranium effluent solutions by the usage of non-homogenous bentonite coated by manganese oxides. Experimental conditions (pH, clay materials quantity to manganese oxide, contact time and associated elements) were changed in order to determine the optimal state for adsorption of 226Ra. Column sorption of radium from uranium effluent solutions from Gattar pilot plant using (Mn-NaB) were conducted. The results showed that good adsorption capacity for radium removal in uranium influent. The capacity at breakthrough point 1.1 Bq/1 is 94.28Bq/g (Mn-NaB).
Clinical Evaluation of Significance of 25(Oh)D Levels in Patients with Organophosphorus Poisoning
Authors: Gupta Bal Kishan , Ranva Anil Kumar , Lal Meena Shyam , Sonkaria Rakesh Kumar , Jigyasa Gupta
Published: October 2018

Introduction: Organophosphate (OP) pesticide poisoning is a major challenging public-health problem in developing countries. Vitamin D deficiency is pandemic, yet it is the most under-diagnosed and under-treated nutritional deficiency in the world and it has been reported to be clinically correlated with psychiatric illness and manifestation of severe systemic inflammatory response syndrome like ARDS. Thus vitamin D deficiency may affect clinical course and outcome in cases of OPP. Aim: To evaluate status of 25 hydroxyvitamin D (25(OH)D) level in OP poisoning and its correlation with outcome of such patients. Materials and Methods: Serum 25(OH)D levels were measured at the time of hospitalization by electro-chemiluminescent Assay in 96 patients (76 male and 20 female) suffering from OP poisoning. Diagnosis of OP poisoning was made by history of poisoning including container of the poison brought by patient’s relative, clinical examination and measurement of serum butyrylcholinesterase activity. All patients were evaluated as per Performa and follow up till discharge. Results: Mean level of 25(OH)D in our cases was 24.57±9.91ng/ml and 66.7% had low levels of 25(OH)D. Our study shows linear relationship between 25(OH)D level and duration of hospital stay. All cases of OP poisoning who developed severe manifestations like ARDS, Intermediate syndrome (IMS) were having significant 25(OH)D deficiency. Our study also shows lower levels of 25(OH)D were associated with poor outcome (11.27±3.21vs 27.02±8.54, p<0.001). Conclusion: Vitamin D deficiency in OP poisoning is associated with longer hospital stay, more requirement of ventilator support and high prevalence of complication (ARDS and IMS) and poor outcome. Awareness of 25(OH)D level in patients with OP poisoning may be important to improve outcome.
The effect of communication training on mother-child communication applied by "from child to mother approach" in mobile kindergarten
Authors: Basit Osman , Ömeroğlu Esra
Published: October 2018

This research was carried out with the aim of examining the impact of communication training based on ‘from the child to mother approach’ on the communication of the mothers with their children attending mobile preschools. The sample comprised 80 children attending mobile preschool and mothers of those children. Two of the five neighborhoods served by the mobile preschool were designated randomly as experiment groups and the remaining as control groups. There were 33 children and mothers in the experimental group and 47 in the control group. The data was collected by General Information Form and Parent-Child Communication Evaluation Tool. During the course of the research, the Communication Training Program prepared by the researcher and based on the Child to Mother Approach was applied to the experimental group for two days in a week during eight weeks. In order to examine the impact of Communication Training Program on mother-child communication, t-test was conducted for both the independent group and the dependent group. Statistical significance was set at .05. As a result of the analyses, it has been determined that the Communication Training Program has a positive effect on communication between mothers and children and this effect is permanent. In line with the results of the research, suggestions for preschool education teachers, parents and researchers are presented.
PEMASARAN POLITIK CALEG PENDATANG BARU DALAM PEMILU (STUDI KASUS WARDI NINGSIH CALEG PAN DAPIL 1 KABUPATEN LAMANDAU)
Authors: Sanjaya Ronny
Published: October 2018

Entering the era of democracy in Indonesia since 1998, impact on the progress of Elections Elections in Indonesia made progress since then, parliamentary elections will directly make the participants prepare a strategy to deal with it. Similarly, participants from District Lamandau. Researchers are searching for a legislative candidate from the district Lamandau newcomers to the dimensions of political marketing. Candidates studied were Wardi Ningsih candidates from the party PAN. This research uses descriptive research. The results of this study are Wardi Ningsih use pull marketing, push marketing, and marketing pass. candidates prepare and deliver a political product with a political marketing approach to deliver its programs to voters.Keywords: Political marketing, Elections, Legislative candidate
PERAN YPKP SEBAGAI KELOMPOK KEPENTINGAN (INTEREST GROUP) DALAM MEMERJUANGKAN HAK HAK KORBAN PERISTIWA G30S (Studi Kasus Aktivitas YPKP di Kabupaten Pati)
Authors: Wisnu Wardhani Adipta
Published: October 2018

Indonesia is one of the countries that embraced democracy in system administration. Indonesia has proved it by holding presidential and vice presidential election directly. Besides the Indonesian people freely organizing meetings and talking freely to express opinions, criticism, or even overseeing the governance system. Freedom of religion is a manifestation of the democratic state.The dynamics of the Non-Governmental Organization (NGO) was born along with the birth of a new order of the early 1970s. The birth of this order to the economic development paradigm and focusing on economic growth, had an impact on short-term plans, medium and long-national development, which is implemented in the five year plan. NGO as a partner of government to accelerate the process of national development in all fields.This research will be directed to find out how YPKP activity as well as how the interaction / relationship dynamics YPKP with the Government. Murder Victims Research Foundation 1965/1966 (YPKP 65) is the organization's first victim in Indonesia fighting for the enforcement of human rights on Human Tragedy 1965/1966. YPKP 65 judging cases of crimes against humanity 1965/1966 has not been seriously considered in law and politics of the country. During the 12 years of reform, none of the political elite, both in Parliament and in the executive, even in the judiciary investigate cases in 1965.After analysis, it appears that YPKP 65 Pati Regency consolidate internally and externally by holding regular meetings so that the communication that exists among members of intertwined smoothly, as did the communications against similar organizations lainnya.YPKP 65 Pati regency using communication media / communication channels that are electronically for obtain information related to the organization's objectives. There was also the dynamics between YPKP with another NGO. Keywords: Role, Interest Groups, Dynamics.