bluuebunny/crossref_metadata_2025 huggingface dataset:
Пересечение броуновским движением границы порядка квадратного корня
Authors: Denisov Denis Eduardovich , Hinrichs Gunter , Sakhanenko Aleksandr Ivanovich , Wachtel Vitalii
Published: April 2022

Рассматриваются времена первого прохождения стандартным броуновским движением границ порядка $c\sqrt {t}$. Основной результат работы определяет хвостовую составляющую распределений таких времен первого прохождения. Он обобщает известные результаты Новикова и Учиямы.
Условная $L^1$-сходимость для мартингала критического ветвящегося процесса в случайной среде
Authors: Hong Wenming , Liang Shengli , Zhang Xiaoyue
Published: April 2022

Рассматривается критический ветвящийся процесс $(Z_n)$ в случайной среде $(\xi _n)$. Найдено достаточное условие, при котором соответствующий мартингал ${Z_n}/{e^{S_n}}$ сходится в $L^1$ или вырождается по мере $\mathbb P^+$, для которой сопровождающее случайное блуждание остается неотрицательным.
Структура популяции частиц для ветвящегося случайного блуждания в однородной среде
Authors: Balashova Dar'ya Mikhailovna , Yarovaya Elena Borisovna
Published: April 2022

Рассматривается симметричное ветвящееся случайное блуждание по многомерной решетке с непрерывным временем и марковским ветвящимся процессом в каждой точке решетки. Предполагается, что в начальный момент времени в точках решетки находится по одной частице и в процессе ветвления частица может произвести произвольное число потомков. Для критического ветвящегося процесса в случае невозвратного случайного блуждания по решетке доказана сходимость распределения поля частиц к предельному стационарному распределению. Показано отсутствие перемежаемости в зоне $|x-y|=O(\sqrt {t})$, где $x$, $y$ - пространственные координаты, а $t$ - время, в предположении суперэкспоненциально легких хвостов случайного блуждания и надкритичности ветвящегося процесса в точках решетки.
Cost-effectiveness of a Dengue Vector Control Intervention in Colombia
Authors: Taborda Alejandra , Chamorro Cindy , Quintero Juliana , Carrasquilla Gabriel , Londoño Darío
Published: April 2022

Dengue is a public health problem in Colombia and in the municipality of Girardot, an area of high risk for dengue transmission. We present the results of an economic evaluation from the societal perspective and 1-year time horizon comparing the regular control program for dengue prevention versus an intervention that comprised an environmental management strategy by covering the most Aedes aegypti productive breeding sites with insecticide covers, community actions, and educational activities. The effectiveness of the intervention was measured as the reduction in probability of dengue infection obtained from a community trial. Resource use was estimated from clinical records that were validated by clinical experts; unit costs were taken from national tariffs. Patient costs were obtained from a household survey. We found that the intervention generated an additional cost of USD20.9 per household and an incremental effectiveness of 0.00173 (reduction in the probability of reported dengue cases). Overall, both alternatives generate similar effectiveness, but the new intervention was associated with increasing costs. We conclude the new intervention is a potentially cost-effective option in areas where high prevalence of dengue exists.
Gene polymorphism of IL6, DHCR7, VDR, CYP2R1, GC in polycystic ovary syndrome and autoimmune thyroiditis
Authors: Valikova O. V. , Zdor V. V. , Sarychev Vladimir Aleksandrovich
Published: April 2022

Polycystic ovary syndrome is a common pathology in women of reproductive age, leading to hyperandrogenism, dyslipidemia, diabetes mellitus, ovulation disorder and infertility. Etiopathogenesis of the disease is actively studied, but many of its mechanisms are unclear. The aim was to study the frequency of IL6 and vitamin D receptor gene polymorphisms, blood contents of vitamin D in polycystic ovary syndrome combined with autoimmune thyroiditis.A total of 192 women were examined, the average age of the patients was 25.5±3.1 years; of these, 130 women had polycystic ovary syndrome. The patients were divided into 2 groups: with polycystic ovary syndrome combined with autoimmune thyroiditis (1st group) and olycystic ovary syndrome without autoimmune thyroid pathology (2nd group); 62 healthy women made up the control sample. The ELISA method was used to determine thyroid stimulating hormone, thyroid hormones, antibodies to thyroid peroxidase, vitamin D, testosterone, estradiol, progesterone, 17-hydroxyprogesterone, luteotropic hormone, follicle-stimulating hormone. Material for genetic studies was isolated from buccal cells. The typing was performed by PCR, and the following polymorphisms were tested: IL6 (rs1800795 SNP), vitamin D receptor (VDR) gene (rs1544410), DHCR7 (rs12785878), GC (rs2282679), CYP2R1 (rs10741657). The results were as follows: polymorphism of IL6, VDR, DHCR7, GC, CYP2R1 genes was revealed in the patients with polycystic ovary syndrome in combination and without concomitant autoimmune thyroiditis. The lowest levels of 25-hydroxyvitamin D in serum were found in the patients with polycystic ovary syndrome and autoimmune thyroiditis.Polymorphism of IL6 genes, vitamin D receptor, DHCR7, GC, CYP2R1 genes may aggravate the course of polycystic ovary syndrome and requires a more comprehensive study. When polycystic ovary syndrome was combined with autoimmune thyroiditis, the studied gene polymorphisms did not differ significantly from those in patients with polycystic ovary syndrome without autoimmune thyroiditis, thus suggesting greater significance of these genetic factors in pathogenesis of polycystic ovary syndrome. However, more than a half of women with combined endocrine disorders had both homozygous and heterozygous variants of pathological IL6 gene carriage along with lowest vitamin D levels, which may significantly affect immune response and, hence, determine the development of both endocrine disorders.
Serum macrophage colony-stimulating factor levels in patients with essential hypertension after vaccination against SARS-CoV-2
Authors: Radaeva O. A. , Simbirtsev A. S. , Kostina Yu. A. , Iskandyarova M. S. , Mashnina S. V. , Negodnova E. V. , Besheynov D. D.
Published: April 2022

The formation of immunity in the population to various variants of the COVID-19 pathogen is one of the most important problems for the world community. The aim of the study was to compare the dynamics of M-CSF and VEGF-A, IL-34 in the blood serum of patients with essential hypertension (EH) stage II, depending on the type of immunity formed (post-infectious, post-vaccination, “hybrid”) to analyze changes of M-CSF-mediated mechanisms of hypertension development. During the work, 2 groups of patients were formed: group 1-patients with stage II EH and SARS CoV-2 infection without pneumonia in the anamnesis, vaccination 6 months after laboratory recovery, group 2 – patients with stage II EH without COVID-19 in the anamnesis, vaccination during the follow-up period. Determination of M-CSF, IL-34, VEGF-A, IgG level to SARS-CoV-2 was determined using an enzyme-linked immunosorbent assay. The formation of post-infectious immunity in patients with stage II EH, despite the mild course of COVID-19, is accompanied by a long-term (up to 6 months) pathophysiologically significant increase in the serum level of M-CSF (p 0.001) with a decrease in IL-34 (p 0.001). Analysis of the dynamics of changes in M-CSF, IL-34, VEGF-A in the postvaccination period in the blood serum of patients with stage II EH with COVID-19 in the anamnesis (“hybrid” immunity), determined the absence (p 0.05) of changes in the levels of M-CSF, VEGF-A after the first component of “SPUTNIK V” against the background of an increase of the level of IgG to SARS-CoV-2. 21 days after the second component of the vaccine, an increase of M-CSF was detected when compared with both pre-vaccination indicators and data 21 days after the introduction of the first component of the vaccine (p 0.001). Comparing the dynamics of the of M-CSF, IL-34 and VEGF-A in patients with stage II EH without COVID-19 in the post-vaccination period with the data on the formation of “hybrid” immunity, an increase in M-CSF was recorded 21 days after the introduction of the first and second components against the background of a decrease in IL-34, but with the restoration of pre-vaccination concentrations in 100% of patients by day 180 with comparable immunogenicity after 180 days. In patients with EH II, the pathogenetic “summation” of the pre-infectious imbalance of cytokine regulation and postcovid changes is important, which in a number of patients may be the reason for the prolongation of the stabilization of the balance of the M-CSF-IL-34-VEGF-A system in the post-vaccination period during the formation of “hybrid” immunity.
Local changes in the type 3 interferons in women with human papillomavirus infection before and after treatment with Inosine pranobex
Authors: Nevezhkina T. A. , Kostyushko A. V. , Krasnikov V. E. , Matyushkina L. S. , Bovdui M. A.
Published: April 2022

Papillomavirus infection remains one of the main causes of pathological conditions of the female reproductive tract. Innate immunity is one of the first protective mechanisms against this infection, with interferon system being one of its elements. Due to ability of HPV for immune evasion, and lack of uniform clinical recommendations and protocols for management and treatment of women with papillomavirus infection, further studies on probable usage of immunomodulatory drugs are an urgent issue for both fundamental and clinical medicine. Currently, a lot of antiviral and immunomodulatory drugs is used in the treatment of virusassociated diseases of urogenital tract associated with a Th1/Th2 type imbalance. However, the drugs with Inosine pranobex as active substance seem to be the most effective and safe drugs for PVI. The aim of our study was to determine type 3 interferons in the cervical mucus of the women before and after Inosine pranobex therapy.We have examined 42 patients with papillomavirus infection treated with drugs with the active substance Inosine pranobex. The average age of women was 31±4.1 years. The levels of IL-29 (IFNλ1) and IL-28 (IFNλ3)in cervical mucosa were determined using specific reagents from RD Diagnostics Inc. (USA). The levels of IL-29 (IFNλ1) were increased in all the groups compared to controls. After treatment, these indexes weresignificantly higher, compared with the group before treatment. IL-28 (IFNλ3) had opposite results to IL-29 (IFNλ1). Thus, in the groups of samples taken before and after therapy, the indexes increased in comparison with the group before treatment, demonstrating the course of recovery towards reference values. The dynamics of studied indexes may be associated with early evaluation period, due to longer duration of immunological changes leading to induction of promoter gene expression, as well as due to insufficient stimulation of these genes. Usage of Inosine pranobex was associated with significantly increased levels of IL-29 (IFNλ1) as soon as a month after therapy. Taking into account genetic homology of type 3 interferons, we may assume that the use of Inosine pranobex drugs in the patients with papillomavirus infection is substantiated, and it may positively affect prognosis of the disease, due to induction of the non-specific immune response.
Can Deep Sea Water be Processed into Potable Water and Distributed into the Middle East?
Authors: Weinert Diane Roessler
Published: April 2022

The study will conclude with a way to develop institutional structures implementing Solow’s conceptualization of inter-generalization that can collaborate peace and increase funds for quality water throughout the Middle East. The study integrates quantitative statistical data and defends the argument that every individual has the right to fresh quality drinking water. The study formulates a hypothesis to gain control, offers visibility into the water industry in the Middle East, and delivers reliable information. Identify what the commonalities between different sectors were and where synergies lay in terms of governance paths (Tiller et al., 2021. P.1). The study is a quantitative, qualitative, and mixed methods approach that includes an e-mail chain, service partners, auditing, and project scope. Synergy and value are targeted with partnerships. Communication of science is implemented to include theory, details, methods, and imperial results. The plan is to gain a comprehensive insight into indicators of water levels and quality with artificial intelligence and synthetic intelligence. Artificial Intelligence can rebuild itself (Capitol Technology, 2022. P.1). Artificial Intelligence that can be transcended containment (Capitol Technology, 2022. P.1). Machine learning is exploding as an application of narrow AI (Artificial Intelligence), used to comb through vast amounts of data to better develop and market products (Capitol Technology, 2022. P.1). Cultural transparency will be investigated along with how the government manages reluctance and how they build strong relationships. A focus is on building a network of founder's challenges facing our world today to demonstrate how interconnected we are and how the fates of all people are bound up together (President Biden, 2021). The outbreak of a virus overseas can cause profound grief and suffer at home (President Biden, 2021). Energy data will be reported to show key metrics and will be compared to countries in the Middle East and measured in amounts of water consumption and renewable energy. “Questions such as these will be answered by world data,” “how water is produced by renewable energy”? Conflict a continent away can create endangers our security (President Biden, 2021). Economic downturns abroad can mean lost jobs and shuttered businesses in towns across the globe (President Biden, 2021). Global climate change worsens hurricanes in the Gulf, floods in the heartland, and wildfires in the West (President Biden, 2021). Because of global warming areas in the world are becoming scarce of potable water for a variety of reasons. Yet what is sure in the oceans is an infinite source of water that is not dependent on rainfall be used to provide potable water for all these drought-stricken regions.
Everyday Europe
Authors: Recchi Ettore , Favell Adrian , Apaydin Fulya , Barbulescu Roxana , Braun Michael , Ciornei Irina , Cunningham Niall , Medrano Juan Diez , Duru Deniz N. , Hanquinet Laurie , Pötzschke Steffen , Reimer David , Salamonska Justyna , Savage Mike , Jensen Janne Solgaard , Varela Albert
Published: April 2022

This book offers an empirically-based view on Europeans’ interconnections in everyday life. It looks at the ways in which EU residents have been getting closer across national frontiers. The book considers how people reconcile their increasing cross-border interconnections and a politically separating Europe of nation states and national interests.
Description of Occupational Disorders in Ayurved and their Management
Authors: Rajendra Kumar  , Guru Sharan Pal  , Vijay Shankar Pandey
Published: April 2022

Everyone needs to do an occupation in the life and every occupation has its own hazards. Many occupational disorders and their preventive and curative management have been described in Ayurved. Due to industrialization, many occupational disorders have been emerged which can be treated by Ayurvedic medicines. Many occupational disorders can be prevented by using advance technology. We should try to prevent the occupational disorders than to treat them. Lifestyles mentioned in Ayurved should be followed to prevent various occupational disorders. We should follow the rules of Dincharya, Ritucharya, Adharniya and Dharniya Vegas, Ahar-vihar to prevent occupational disorders. Yoga is also beneficial to maintain occupational health. Chapters regarding occupational health can be added in the syllabus of UG and PG courses of Ayurveda. Post Graduate Diploma in Occupational Health (PGDOH) course can be started by the government. Such doctors can take care of employees in maintaining the occupational health. It is better to prevent occupational disorders than to treat them. Acharya Charak also emphasizes on prevention of diseases by explaining Swasthasya Swasthyarakshnam at first.
Establishing the Correct Identity of Jalakumbhi in Ayurveda: A Critical Analysis Based on Various Literatures
Authors: Sameeksha Rauthan  , Dhruv Mishra  , Rajesh Mishra
Published: April 2022

Jalakumbhi is an effective Ayurvedic medicinal plant in the indigenous system of medicine which is found abundantly as a spread of a velvety carpet in mushy water bodies. This drug is known to Ayurveda practitioners since the Nighantu Kala. Jalakumbhi mentioned in Ayurvedic classics can be compared to Pistia stratiotes var. cuneata. but it is usually confused with Eichhornia crassipes also known as Pontederia crassipes thus making it controversial. This could be due to various reasons such as documentation defects in the manuscripts, same synonyms, habitat or morphology. All parts of the plant can be utilized for preparation of medicine for various diseases. The plant shows anti-thyroid, diuretic, antipyretic, anti-hemorrhoid, bronchodilator properties as well as can be used in various bleeding disorders in addition to in individuals suffering from emaciation, Sagrahani, Karnapaka, prickly heats etc. Here, an attempt is made to review the various therapeutic properties of Jalakumbhi along with its etymology, morphology and pharmacological aspects. We will also work to review and differentiate the plant which is confused as Jalakumbhi and rule out the reason behind such controversies. Various Ayurvedic and modern texts along with the latest researches have been analyzed and the concept concluded. The study shows both ayurvedic and modern explanation of this aquatic plant thus, giving correlation on the scientific basis of Ayurvedic drug Jalakumbhi and the use of it in various diseases. It will also set strong background for the drug which is mentioned as Jalakumbhi in our sacred compendiums
Ayurveda in Management of Iron Deficiency Anemia: A Case Report
Authors: Shreya Joshi  , Abhishek Bhushan Sharma
Published: April 2022

Nutritional iron deficiency anemia is the most common cause of anemia and a global public health problem among young children and pregnant women. Blood loss, malabsorption is the common cause of iron deficiency anemia. Pandu roga is a clinical entity with great resemblance to iron deficiency anemia. Pandu roga is Pitta pradhan vyadhi. In Pandu roga tissue metabolism gets affected due to vitiated Doshas which in turn into Dhatu- shyathilya in all Dhatu. There is a predominance of paleness all over the body. Rasavaha and Raktavahasrotasas are chiefly involved in the pathogenesis of Pandu. So, here is a case report of 21 years old female patient with iron deficiency anemia who was given Ayurvedic formulations in the line of treatment of Pandu roga along with dietary supplements rich in iron for a period of one month and marked improvement in symptoms (i.e., swelling was reduced, pallor absent, she was feeling energetic, hair fall (10 strands/day), palpitation had also decreased) with increase in hemoglobin level (i.e., from 8.6g/dl to 12.7g/dl) in a very short duration of time. The formulations help in breaking the Samprapti of Pandu roga. This shows the efficacy of Ayurvedic medicine in the treatment of iron deficiency anemia (Pandu).
The influence of Plato and Aristotle on Leo Strauss
Authors:   Classical Philologist, MSc, Doctoral Researcher - PhD Candidate at National Technical University of Athens, Karakoulas Dimitrios
Published: April 2022

The article deals with the influence of Plato and Aristotle on the philosophical work and thought of Leo Strauss. Significant issues are approached, which are directly related to the Platonic and Aristotelian views of politics, always in connection with the direct crisis of nihilism brought about by the age of modernity. The interpretations given should be taken as a result of Strauss's own research into the history of philosophy in an attempt to deal with political problems philosophically. Given that Strauss's approach to Platonic and Aristotelian texts is unorthodox, the philosopher attempts to address complex political issues through the scope of their reinterpretation in a selectively synthetic way.
Leadership as a Factor of School Quality in International Schools
Authors:   Faculty of Business, Economics and Social Development, Universiti Malaysia Terengganu, Terengganu, Malaysia, Alhebshi Sukainah Hasan Saleh
Published: April 2022

The success of an international school is affected by a multiple of factors, most of which contribute to the quality of learning. One of these factors is related to the role of a principal whose leadership quality impacts learning processes. School principals are in charge of developing staff, setting directions, and redesigning the institution. The current paper aims at revealing these qualities and responsibilities that may contribute directly to enhance learning processes. It also attempts to evaluate principals’ roles in allowing teaching staff and admins to share responsibility and be engaged in building trust and strengthening relationships and roles. The results of the paper indicate that the roles of effective principals rely on positive impact on the school staff.
Frecuencia de mortalidad en pacientes con artritis reumatoidea en un centro de reumatología de Argentina
Authors: Saint Martin María Emilia , Correa María de los Ángeles , Schneeberger Emilce Edith , Valerio María del Carmen , Buschiazzo Emilio , Dal Para Fernando , Marengo María Florencia , Citera Gustavo
Published: April 2022

La Artritis Reumatoidea (AR) es una enfermedad inflamatoria crónica que se asocia a disminución de la capacidad funcional, de la calidad de vida y aumento de la mortalidad. El objetivo de este estudio fue evaluar la mortalidad en una cohorte de pacientes con AR, y la influencia de factores sociodemográficos, clínicos y de laboratorio.Pacientes y métodos: Se analizó una cohorte de pacientes con diagnóstico de AR, (criterios ACR’ 87), evaluados entre los años 2004 y 2010. Se recolectaron datos sociodemográficos, características de la enfermedad, clínicas, analíticas, tratamientos recibidos y comorbilidades. Radiografías de manos y pies fueron leídas por medio del índice de Sharp van der Heijde por 3 observadores independientes ciegos (CCI ≥0,8). En caso de discontinuación del seguimiento, se realizó contacto telefónico. Se identificaron los pacientes fallecidos durante el período estudiado y se determinó la causa de muerte. Análisis estadístico: Estadística descriptiva, para la comparación de datos categóricos se utilizó test de Chi2 o test exacto de Fisher y para las variables continuas test t de Student o Mann Whitney según la distribución de la muestra. Los factores asociados a mortalidad se analizaron por regresión logística múltiple. Se consideró significativa una p <0,05.Resultados: Se evaluaron 307 pacientes, de los cuales 45 perdieron seguimiento y 262 pudieron ser reevaluados a los 5 años de seguimiento. De los 262 pacientes, 86,3% eran de sexo femenino, la edad mediana fue de 58 años (RIC 50-67), la edad mediana al inicio de la AR fue de 40 años (RIC 31-50) con un tiempo mediano de evolución de 15 años (RIC 10-21). 17 pacientes (6,5%) fallecieron.En el análisis univariado, mayor edad, menor escolaridad, presencia de comorbilidades gastrointestinales y uso de tratamiento biológico, estuvieron significativamente asociados con mayor mortalidad.En el análisis de regresión logística múltiple, peor nivel educativo y uso de tratamiento biológico estuvieron significativamente asociados con mortalidad.Conclusión: La mortalidad de pacientes con AR en un centro de Argentina, en un período de 5 años fue de 6,5%. Peor nivel educativo se asoció con mortalidad. Al no ser un estudio longitudinal, la asociación con tratamiento biológico podría estar relacionada a un sesgo por indicación en pacientes con enfermedad más severa.
De médicos y literatura
Authors: Paira Sergio
Published: April 2022

Con motivo del Certamen Literario de la Sociedad Argentina de Reumatología 2014, de cuyos ganadores se publican los cuentos y poesías en este número de la revista, el Dr. Sergio Paira, que fue el ideólogo y promotor del mismo, ha escrito el siguiente artículo editorial
Ultrasonografía en artritis reumatoidea
Authors: Cazenave Tomás
Published: April 2022

La ultrasonografía (US) es ampliamente utilizada en la evaluación y el seguimiento de las enfermedades reumáticas, siendo una herramienta válida, reproducible y capaz de demostrar sensibilidad al cambio.

La evaluación de los pacientes con Artritis Reumatoidea (AR) combina la escala de grises (EG) con la técnica Doppler de poder (DP). Las imágenes en EG sirven para describir las estructuras anatómicas, y la técnica DP permite visualizar el flujo sanguíneo de pequeños vasos y detectar el aumento anormal de la vascularización debido al compromiso inflamatorio. Su indicación en la práctica habitual incluye la evaluación de estructuras intra y periarticulares, permitiendo visualizar con gran resolución los tejidos blandos y los cambios de la cortical ósea en todas las etapas de la enfermedad. La US es particularmente útil para describir los procesos inflamatorios de la AR (sinovitis, tenosinovitis y bursitis) y los cambios estructurales (erosiones óseas, daño del cartílago y lesiones tendinosas). Por otro lado, la US ha demostrado propiedades diagnósticas similares a la resonancia magnética (RM) en la detección de sinovitis y tenosinovitis, y permite visualizar erosiones óseas en etapas más precoces que la radiología convencional.
Ustekinumab en psoriasis cutánea y artritis psoriásica
Authors: Rosa Javier E. , Soriano Enrique R.
Published: April 2022

La artritis psoriásica (APs) es una enfermedad articular inflamatoria crónica, que se ha clasificado dentro del grupo de las espondiloartritis. La psoriasis cutánea afecta alrededor del 2 al 4% de la población general mundial, y entre el 6% y el 42% de los pacientes con psoriasis desarrollarán APs según estudios en distintos lugares del mundo, y el 17% en Argentina, según un estudio desarrollado por Maldonado Ficco y cols3. En nuestro país en la población general, la APs tiene una prevalencia de 74 (IC 95%: 57, 94) casos por 100 000 personas, una incidencia de 6,26; (IC 95: 4,2, 8,3 casos) por 100 000 personas/años. Los datos de prevalencia de APs en pacientes con psoriasis son variables en la literatura, y esto es debido, en parte, a la heterogeneidad de la enfermedad y a los diferentes criterios para definirla. La APs afecta por igual a hombres y mujeres y su incidencia es mayor en adultos entre los 30 y 50 años. El compromiso cutáneo aparece antes del compromiso articular en el 75% de los pacientes con APs, después de la artritis en el 15% y en un 10% de los pacientes, ambas aparecen en forma simultánea.
Estudio multicéntrico no intervencional en pacientes con artritis reumatoidea tratados con tocilizumab
Authors: Montoya F.
Published: April 2022

Introducción: Tocilizumab es un anticuerpo monoclonal humanizado anti-receptor de IL-6 que ha demostrado eficacia y seguridad en artritis reumatoidea (AR).Métodos y objetivos: Estudio observacional de cohorte en pacientes con AR moderada a severa tratados con tocilizumab con 6 meses de seguimiento. El objetivo primario fue establecer la adherencia al tratamiento y secundariamente estudiar la efectividad y seguridad.Resultados: Cincuenta pacientes fueron tratados con tocilizumab (86% asociados a DMAR y 14% a monoterapia). La adherencia fue 42/50 (84%; IC 95%: 71-93%) y el porcentaje de respuesta luego de 6 meses según criterios de la ACR20/50/70/90 fueron 68,2%, 40,9%, 13,6% y 9,1% respectivamente. El recuento de 28 articulaciones dolorosas (TJC28) e inflamadas (SJC28) se redujo significativamente de 12 y 8 en el momento basal a 5 y 2 a los 6 meses respectivamente (p <0,001). Se observó una reducción significativa en los parámetros de evaluación de actividad del médico y en las evaluaciones reportadas por el paciente. No se registraron eventos adversos de intensidad severa ni eventos adversos serios relacionados con la medicación.
Adaptación de la versión para pacientes de las recomendaciones para el tratamiento hacia un objetivo (T2T) en artritis reumatoidea para su uso en Argentina
Authors: Velasco Zamora José Luis
Published: April 2022

En el año 2008 fueron publicadas las recomendaciones para el tratamiento hacia el objetivo en artritis reumatoidea (treat to target: T2T). Originalmente diseñadas como recomendaciones para guiar a reumatólogos en el tratamiento de la AR, en el año 2011 se public la primera versión para pacientes de estas recomendaciones en inglés.Objetivo: validar la versión para pacientes de las recomendaciones T2T para su uso en Argentina a través de la adaptación transcultural de la versión original.Método: Se realizó un proceso de adaptación transcultural a partir de la versión original. De este proceso de traducción y retraducción y del análisis por parte de un comité de expertos, se obtuvo una versión prefinal. Esta versión fue sometida a una prueba de campo mediante una entrevista a pacientes alfabetos consecutivos con diagnóstico de AR en diferentes centros de Buenos Aires, Ciudad de Buenos Aires y Santa Fe. En esta entrevista se evaluó validez de forma, equivalencia conceptual, interpretabilidad y aceptabilidad. El resultado obtenido de estas entrevistas fue discutido con el comité designado de investigadores para desarrollar una versión final de la pieza validada.
Análisis de la actitud del alumnado y el profesorado ante el contenido de Expresión Corporal y los estereotipos de género: Resultados de la experiencia tras la realización de una Unidad Didáctica (Analysis of improvements in the attitudes of students and
Authors: Bonet Montserrat , Menescardi Cristina
Published: April 2022

El objetivo de esta investigación es conocer la opinión del alumnado sobre la Expresión Corporal y la percepción que tiene el profesorado de este contenido, así como analizar si existen estereotipos sobre este contenido por parte de los participantes. Un total de 66 alumnos y su profesora han participado en este estudio. Para cumplir con los objetivos del trabajo, se suministró a los participantes el cuestionario de actitudes hacia la expresión corporal antes y después de la realización de una Unidad Didáctica. Los resultados mostraron que diferencias significativas en la valoración, agrado y consideración del profesorado tras la realización de la Unidad Didáctica. Se concluye que la opinión del alumnado tras esta experiencia concreta ha mejorado puesto que en un primer momento gran parte del alumnado no practicó Expresión Corporal, asimismo se destaca que la opinión entre alumnado y profesorado es similar y que prácticamente no existen estereotipos alrededor de la Expresión Corporal. 
Abstract. The aim of this study was to analyse students’ opinions about body expression and their teacher’s perception of the contents of a corresponding unit of work, as well as to investigate the existence of stereotypes about body expression. In total, 66 students and their teacher participated in this study. Participants completed the questionnaire on attitudes towards body expression before and after studying the teaching unit. The results showed significant differences in the degree of satisfaction, enjoyment, and teachers’ consideration expressed by the students after completing the unit of work. It was concluded that the students’ opinions improved after studying the unit focused on body expression, especially since a large proportion of the students had not studied a unit of this nature before. Our results also highlighted the similarity between the opinions expressed by students and their teacher, and at the end of the unit, almost no indications of stereotypical beliefs associated with notions of body expression were evident among the participants.
Propiedades psicométricas de la escala WP-FootballTeams sobre motivos de uso de páginas web (Psychometric properties of the WP-FootballTeams scale on websites use reasons)
Authors: Fernández-Martínez Antonio , Falcón Miguel David , Pérez-Ordás Raquel , Nuviala Nuviala Román , Nuviala Nuviala Alberto
Published: April 2022

Las organizaciones deportivas pueden tener una relación más cercana con sus seguidores y aprender de ellos a través de sus interacciones sociales en comunidades virtuales. El objetivo fue constatar la validez, fiabilidad y estructura factorial de la escala de motivos de uso de páginas web de equipos de fútbol. Tras los análisis factoriales confirmatorios se obtuvo un cuestionario reducido compuesto por siete dimensiones, con 21 ítems, con una gran proporción de varianza explicada y fiabilidad alta. Estos resultados constataron que se trataba de un instrumento fiable y válido, acreditándolo como útil para la gestión y la investigación, con una fácil puesta en práctica, pudiendo ser utilizado de forma periódica por los responsables de las organizaciones deportivas, permitiendo la comparación entre éstas. Los resultados han permitido presentar una herramienta capaz de conocer los motivos por los que las personas aficionadas al fútbol utilizaban las páginas web de los equipos.
Abstract. Sports organizations may have a closer relationship with their fans and learn from them through their social interactions in virtual communities. The aim was to test the validity, reliability and factor structure of the scale of reasons for using football team websites. The confirmatory factor analyses resulted in a reduced questionnaire composed of seven dimensions, with 21 items, a high proportion of explained variance and high reliability. These results showed that it was a reliable and valid instrument, accrediting it as useful for management and research, easy to implement, and can be used periodically by those in charge of sports organizations, allowing for comparison between them. The results have made it possible to present a tool capable of finding out the reasons why football fans use the teams' websites.
Impacto emocional de la actividad física: emociones asociadas a la actividad física competitiva y no competitiva en educación primaria (Emotional impact of physical activity: emotions associated with competitive and non-competitive physical activity in p
Authors: Álvarez-Ibáñez David , Fernández-Hawrylak María
Published: April 2022

La práctica de actividad física puede generar emociones positivas y negativas, en función del tipo de actividad física que se realice. Se presenta un estudio cuasiexperimental con pre-test y post-test, cuyo objetivo es comparar el impacto emocional que produce la práctica de actividad física competitiva y no competitiva en Educación Física. Se utilizó el cuestionario POMS (Profile of Mood States) (Gómez, 2015), analizando los factores de depresión, vigor, cólera, tensión y fatiga en una muestra de 43 estudiantes con una edad comprendida entre 11 y 12 años (M = 11.3, DT = 1.2) en un centro concertado de la ciudad de Burgos, España. Los factores depresión y cólera fueron estadísticamente significativos cuando se comparó su puntuación diferencial entre la práctica de actividad física competitiva y no competitiva, siendo mayores estos factores, asociado a emociones negativas, durante la práctica de actividad física competitiva. Se concluye que la actividad física competitiva podría generar emociones negativas en el alumnado. 
Abstract. The practice of physical activity can generate positive and negative emotions, depending on the type of physical activity that is carried out. We present a quasi-experimental study with pre-test and post-test, whose aim is to compare the emotional impact that the practice of competitive and non-competitive physical activity in Physical Education produce. The POMS questionnaire (Profile of Mood States) (Gómez, 2015) was applied to analyze the depression, vigor, anger, tension and fatigue factors in a sample of 43 students, aged between 11 and 12 years (M = 11.3, SD = 1.2) in a 'concertada' school (private school with public funding) in the city of Burgos, Spain. The depression and anger factors were statistically significant when their differential score was compared between the practice of competitive and non-competitive physical activity, being these factors, associated with negative emotions, greater during the practice of competitive physical activity. We conclude that competitive physical activity could generate negative emotions in students.
Overview of the Skills Required for Marine Protection and Ocean Governance
Authors: Vrancken Patrick
Published: April 2022

This paper provides an overview of the skills required for marine protection and ocean governance by focusing on five aspects on a regional basis, namely maritime knowledge, maritime awareness, maritime safety, maritime security and maritime integrity. It is concluded that a focus on the development and retention of the skills required in these regards is necessary for the state to optimally govern the South African maritime domain in the interests of all South Africans, to ensure that South Africa protects its lawful interests on the high seas and to enable South Africa to make its full contribution to the integrated governance of the African maritime domain.
Human Sciences Research Council’s Labour Market Intelligence Partnership Study and Lessons for the Maritime Sector – A Labour Market Theoretical Perspective
Authors: Mapadimeng Mokong S
Published: April 2022

To best understand the changing nature of labour markets and how they function, it is necessary to base our analysis on both the empirical evidence and appropriate theoretical frameworks. This is particularly so as theory is about real-life situations and enhances our understanding of how the world around us works and changes. Theory also guides inquiry into social questions for a better understanding of how they can be resolved. With this in mind, this paper examines the findings of the Human Sciences Research Council’s (HSRC) Labour Market Intelligence Partnership (LMIP) studies, and specifically the 2016 report on Skills Supply and Demand in South Africa. This it does through the deployment of the contemporary labour market theories. In doing so, lessons for the maritime sector, which is presently seeking to implement its skills planning and employment creation plans, are discussed. The paper finds that while the LMIP lays foundation for future skills planning, its analysis is, however, not explicitly and adequately anchored into contemporary labour market theories. This is a major shortcoming as these theories alert us to issues that LMIP is not adequately giving attention to, i.e., the socially structured and segmented nature of the labour markets under the competitive pressures of globalisation and technological changes.
A Proposed Education-Industry Partnership for Skills Development in the Marine Manufacturing Sector
Authors: Davidson Vanessa
Published: April 2022

The marine manufacturing sector is a diverse and multi-faceted industry with a wide range of different skills sets that often overlap with other sectors. A few specialist qualifications have been developed but a disjuncture exists between industry and education who have difficulty in finding a common language to talk about skills partnerships. Four studies between 2016 and 2018 focused on marine manufacturing and skills provision are reviewed and their key findings elucidated. The paper forefronts different conceptual frameworks underpinning skills planning, it questions who is responsible for the development of qualifications and curricula and lastly raises the divergent views of industry and education with respect to skills responsiveness and changing production contexts and innovations. The paper concludes there is a need to narrow the gap between training provision and industrial work contexts. It is proposed that this could be achieved through strong leadership and well-resourced training provision that is responsive and flexible. The need for a mutual understanding needs to underpin any interventions such as group training models and relevant partnerships between industry associations and training providers.
Applying Systems Thinking Approach to Enterprise Development
Authors: Zulu Vincent Bukelani , Ndlozi Malibongwe
Published: April 2022

In an increasingly complex, turbulent and rapidly changing environment, enterprise development actors have their hands full in designing and delivering effective enterprise development programmes. While enterprise development is a complex system, it also interacts with the education system and labour market systems, among other systems, thereby increasing the number of actors/agents within these systems, their interrelationships and their connectedness. To address this increased complexity, this paper argues for a systems thinking approach to enterprise development. The authors will discuss systems thinking concepts, the structure of enterprise development and their related systems. Three causal loop diagrams and systems thinking archetypes are used to discuss enterprise development.
What Skills and Capacity Building Interventions are Required to Grow the South African Aquaculture Sector?
Authors: Halley Keagan , Bernatzeder Andrea
Published: April 2022

Aquaculture is a knowledge- and technology-driven sector that requires a diversity of skills. Such skills are often demonstrated by professionals, including those of veterinarians, biologists, oceanographers, chemists, economists, managers, engineers, artisans, environmentalists and researchers. Since the sector is still fairly small in South Africa, a limited number of institutions provide aquaculture training and their primary focus is on tertiary education. Extension support is also limited in terms of state extension officers, veterinarians and researchers (government does not have the capacity to service the entire sector) and there is little awareness of aquaculture farming as a career and education option. In 2017, a thorough skills inventory and needs analysis of the sector was conducted, led by the South African International Maritime Institute (SAIMI) and the current Department of Forestry, Fisheries and the Environment (DFFE).1 These research efforts were aimed at identifying the shortfalls and future needs in terms of skills and education and training, as well as determining the current age representation and race participation in the industry. Data collection was conducted using interviews and focus groups. The study identified scarce skills and existing gaps, such as supervisory and management skills for middle and senior managers in the sector. Increased awareness of learnerships and funding opportunities through the Sector Education Training Authority (SETA) was flagged.
Quality Assurance for Achievement of the Objectives of Basic Education in Kwara and Kogi State of Nigeria
Authors:   Assistance Chief Education Officer, Ibrahim Yusuf Laro ,   National Teachers’ Institute, Kaduna Kogi State Office, Lokoja, Fasasi Yunus A ,   Prof. H.O.D Department of Educational Management, Faculty of Education, University of Ilorin, Ilorin, Modibbo Ahmed Tahir ,   Senior Education Officer; National Teachers’ Institute, Kaduna, Sulaiman Isiaka Salman ,   Senior Education Officer; National Teachers’ Institute, Kaduna Kwara State Office, Lokoja
Published: April 2022

Basic education is vital to the national development. The government of the federal republic of Nigeria invested financial, human and material resources in it so that its objectives could be achieved. However, two decades after its implementation, the nation is yet to overcome most of economic and socio-political challenges it was meant to address. This could be due to poor quality graduates turned out from basic education institutions in particular and all level of education in general. Thus, there is need to investigate the quality management process in education system. Basic education provides the foundation for other levels of education and its quality would determine, to a large extent, the quality of education at higher levels. This paper therefore examines the quality assurance adopted in the implementation of basic education Programme and the extent of achievement of basic education objectives in Kwara and Kogi State of Nigeria with a view to suggesting possible ways of improvement
Dimensionamento estrutural do sistema de balance bar e pedal de um veículo Baja SAE
Authors: Silva Ayslan Augusto de Almeida , Franceschine Rafael Jayme , Reis Flávia de Oliveira , Tolomei Rafael de Souza , Freitas Maria Carolina dos Santos
Published: April 2022

O protótipo Baja SAE é um veículo off-road projetado por estudantes com o objetivo de participar de competições que testam sua confiabilidade e eficiência. Perante o exposto este artigo tem como objetivo o dimensionamento estrutural do sistema balance bar e pedal, desta forma, a análise estrutural dos componentes visa garantir a resistência e uma baixa massa do protótipo, sendo assim no subsistema de freio a balance bar e pedal devem ser analisados estruturalmente, garantindo um dimensionamento seguro. A análise do sistema de balance bar deve se utilizar de condições de contornos reais, cálculos concretos e por software, assim o processo de dimensionamento busca ajudar a definir a melhor geometria que suporte os carregamentos impostos ao veículo baja SAE. Sendo assim é necessário saber analisar os componentes e as condições de contorno, desta forma, chegando em peças resistentes e seguras.
Fenômenos químicos e físicos: uma prática experimental com o 4º ano do Ensino Fundamental
Authors: Rodrigues Matheus Felipe dos Reis , Amaral Sylvia Stella , Ramos Anderson Rodrigues , Bajur Anne Paulino , Costa Fernanda de Jesus
Published: April 2022

A presente pesquisa objetiva analisar as contribuições de uma prática experimental sobre os fenômenos químicos e físicos, realizada com estudantes do 4º ano do Ensino Fundamental I em uma escola pública localizada no Município de Ibirité (MG). Este estudo é caracterizado por uma abordagem quali-quantitativa, sendo que os dados obtidos resultam da observação e de um questionário respondido pelos estudantes participantes. A análise dos dados demonstra que cerca de 70% dos discentes conseguiram identificar de maneira correta os experimentos realizados como sendo fenômenos de ordem química ou física.  Porém, quando solicitamos que classificassem os experimentos conforme seu caráter (químico ou físico), a porcentagem de acertos caiu para aproximadamente 50%. Esse resultado demonstra, possivelmente, uma dificuldade na compreensão de parte do instrumento avaliativo usado. Entretanto, a participação dos discentes e as discussões realizadas com a turma indicam que a metodologia usada pode ser considerada uma ferramenta eficiente para o ensino do conteúdo de fenômenos químicos e físico.
Prospecção científica sobre o uso da cinza da cana-de-açúcar em tijolos
Authors: De Almeida Silva Humberto Denys , Bezerra da Silva Hitalo de Jesus , Dos Santos Valdeci Bosco , Elias de Matos José Milton
Published: April 2022

O tijolo é um dos elementos mais importantes na indústria da construção civil. Com o intuito de minimizar os impactos negativos de seu processo produtivo e melhorar suas propriedades físicas e mecânicas, diversos estudos têm buscado por matérias-primas alternativas. Nesse sentindo, o presente trabalho procurou avaliar o potencial tecnológico do uso de cinza de cana-de-açúcar na produção de tijolos através de uma prospecção científica em bases de artigos, no período de 2003 a 2021. Um maior número de publicações relacionadas às cinzas de cana-de-açúcar adicionadas a tijolos foi observado para o ano de 2018. Embora seja possível perceber estudos promissores e uma tecnologia em estado de aperfeiçoamento, pode-se concluir que o interesse pelo tema proposto é ainda muito incipiente. Dessa forma, necessita-se de mais investimentos dos agentes responsáveis para consolidação do desenvolvimento científico e tecnológico.