bluuebunny/crossref_metadata_2025 huggingface dataset:
Alpha synuclein by RT-QuIC in dementia with Lewy Bodies: a systematic review and meta-analysis
Authors: PEÑA-BAUTISTA Carmen , KUMAR Rakesh , BAQUERO Miguel , CHÁFER-PERICÁS Consuelo , ABELEIN Axel , FERREIRA Daniel
Published: January 2023

Dementia with Lewy Bodies (DLB) is the second most common cause of neurodegenerative dementia but the field is still lacking a specific biomarker for its core pathology: alpha-synuclein. Real-time quaking induced conversion (RT-QuIC) has recently emerged as a strong candidate of alpha-synuclein biomarker. However, the variability in the technique parameters and the heterogeneity of DLB patients makes complex the reproducibility of the results. We provide an overview of the state-of-the-art research with regard to RT-QuIC in DLB focused on: (1) the capacity of RT-QuIC to discriminate DLB from controls, Parkinson’s disease (PD) and Alzheimer’s disease (AD); (2) the capacity of RT-QuIC to identify prodromal stages of DLB; (3) and the influence of co-pathologies on the RT-QuIC’s performance. We also assessed the influence of different factors on the RT-QuIC’s performance, such as technical conditions (e.g. temperature, pH, shaking-rest cycles), sample type, and clinical diagnosis versus autopsy confirmation. Our meta-analysis shows that RT-QuIC reaches very high diagnostic performance in discriminating DLB from both controls (pooled sensitivity and specificity of 0.94 and 0.96, respectively) and AD (pooled sensitivity and specificity of 0.95 and 0.88), and is promising for prodromal phases of DLB). However, the RT-QuIC’s performance to discriminate DLB from PD is currently low due to low specificity (pooled sensitivity and specificity of 0.94 and 0.11). Further, our analyses showed that the RT-QuIC’s performance is not substantialy influenced by sample type or clinical diagnosis versus autopsy confirmation. Co-pathologies did not seem to influence the RT-QuIC’s performance, but the number of studies is currently limited. We observed technical variability across studies but, for the published articles, we could not find that this variability has a clear effect on the reported results. We conclude that there is currently enough evidence to test alpha-synuclein by RT-QuIC for clinical use. We anticipate that harmonization of protocols across centres and advances in standardization will facilitate the clinical establishment and generalization of alpha-synuclein by RT-QuIC.
Super-forecasting the ‘technological singularity’ risks from artificial intelligence
Authors: Radanliev Petar , De Roure David , Maple Carsten , Ani Uchenna
Published: January 2023

This article investigates cybersecurity (and risk) in the context of ‘technological singularity’ from artificial intelligence. The investigation constructs multiple risk forecasts that are synthesised in a new framework for counteracting risks from AI itself. In other words, the research concern in this article is not just with securing a system, but to analyse how the system responds when (internally and externally caused) failure and compromise occur. This is an important methodological principle because not all systems can be secured, and we need to construct algorithms that will enable systems to continue operating even when parts of the system have been compromised. Furthermore, the article forecasts emerging cyber-risks from the integration of artificial intelligence in cybersecurity. Based on the forecasts, the article is concentrated on creating synergies between the existing literature, the data sources identified in the survey and forecasts. The forecasts are used to increase the feasibility of the overall research and enable the development of novel methodology that uses AI to defend from cyber risk. The methodology is focused on addressing the risk of AI attack, as well as to forecast the value of AI in defence and in the prevention of AI rogue devices acting independently.
HEGEMONI KEKUASAAN ANTONIO GRAMSCI DALAM CERPEN “SHARAHKH AL-QUBUR” KARYA KAHLIL GIBRAN
Authors: Junaidi Muhammad Mahbub
Published: January 2023

Cerpen Sharahkh al-Qubur dalam antologi  Al-arwah Al-mutamarridhah mengandung suatu hegemoni yang dilakukan oleh suatu pihak elit politis, terhadap beberapa kelompok yang didominasi. Hegemoni tersebut lebih dipengaruhi oleh ideologi-ideologi kaum penguasa di tengah-tengah masyarakat saat itu, sehingga cerpen ini membutuhkan pisau analisis hegemoni kekuasaan Antonio Gramsci untuk membedah isi dan kandungan yang menonjolkan sisi-sisi hegemoni yang ada. Penelitian ini bertujuan untuk mengungkapkan bentuk ideologi-ideologi tersebut beserta penjelasan terkait pengaruhnya pada kehidupan sosial masyarakat yang secara tidak sadar dikurung dalam hegemoni yang dibuat oleh kelompok penguasa. Penelitian ini merupakan sebuah penelitian literatur atau penelitian kepustakaan dengan objek cerpen Sharahkh al-Qubur dalam antologi  Al-arwah Al-mutamarridhah. Sementara itu dalam menganalisis data, penulis menggunakan teknis analisis isi model aliran Miles dan Hubermen dengan beberapa langkah, diantaranya tahap reduksi data, tahap penyajian data, dan tahap penarikan kesimpulan. Hasil dari penelitian ini menunjukkan bahwa cerpen tersebut mengandung hegemoni integral atau menyeluruh berupa masyarakat yang terbawa ideologi penguasa membuat masyarakat masuk dalam politik dan dengan sendirinya akan memihak kepada keputusan sang raja, selain juga rajanya dikenal dengan tegas dan adil menegakkan supremasi aturan. Kedua, hegemoni decadent atau merosot berupa masyarakat seakan telah mengalami potensi disintegrasi dan  masih mempertanyakan kemungkinan yang benar terjadi atau tidaknya terhadap kejadian seorang lelaki tua mencuri tepung hidangan suci yang terjadi saat keluarganya dalam keadaan kelaparan. Kesimpulan dari penelitian ini adalah hegemoni yang mendominasi dari ketiga hegemoni Gramsci yaitu hegemoni integral.
REVEALING EXPRESSIONS OF HAPPINESS AND SADNESS IN STUDENTS’S ESSAYS BY GRADE 3rd AND 5th ELEMENTARY SCHOOL STUDENTS
Authors: Khoirunnisa Krismonika
Published: January 2023

Psycholinguistics study is a study that focuses on language acquisition, both normal language acquisition (children in general), and language acquisition for children with special needs. Each person's language acquisition goes through a different process. The acquisition of the language is obtained from several factors that support the individual. This is evidenced by several other supporting factors such as environmental factors, age, intelligence, education, talent, demand, and others. This study will try to focus on the study of language acquisition taken from the essays of 3rd and 5th grade elementary school students. By using the theme “My Hope”, the researcher took two samples of student essays by partitioning two essays from 3rd grade elementary school students and two essays from 5th grade students as a form of comparison. The four essays obtained will later be compared how they express their expressions of happiness and sadness in their essays. The results of this study indicate that not all students who experience homeschooling do not have skills in processing written language. Likewise with they levels. A high level does not necessarily indicate that the student is able to process written language well. This research is a type of qualitative descriptive research. This research consists of three stages, namely the stage of data collection, data analysis, and exposure of the results of data analysis. The data collection technique carried out in this study consisted of one stage, namely the analysis of students' thinking processes through tests. The data analysis technique in this study used the analysis of morphological and syntactic elements that were adjusted to age and level (class). This analysis is used to determine the emergence of an element that is a reflection of the child's competence or is a new competence that they get.
Tipologi Arsitektur Vernakular Melayu Uma Kabuong Limo di Kampung Pulau Belimbing, Kabupaten Kampar
Authors: Husaini Muhammad Arief Al , Hidayat Wahyu , Mashuri Mashuri , Kuswoyo Indra
Published: January 2023

Title: Typology of Malay Vernacular Architecture Uma Kabuong Limo in Pulau Belimbing Village, Kampar District
 
One form of residential culture can be seen in the architecture as a residence for the people of Belimbing Island Village, Kampar regency. The house as a residential function always develops according to the needs and image of the owner, so changes in the Uma Kabuong Limo building are found. Uma Kabuong Limo can be categorized as vernacular architecture because Uma Kabuong Limo is a product and name that has existed for several generations with a development process that adapts the socio-cultural and cultural of the Malay community. The nature of this simplicity is not only a residential building but also becomes the identity of the community. Through the study of the architectural typology of Uma Kabuong Limo was studied through the approach of the computational model of heritage building information modeling (HBIM). This modeling is expected to get an in-depth and precise analysis to describe the typology process more accurately. This assessment process begins with field data observation, modeling, and discussion of building typologies. The Uma Kabuong Limo buildings observed are six buildings representing the distribution of facilities in The Belimbing Island Village. The findings were the existence of a slightly different basic shape equation in the kitchen. One of the buildings changed the shape of the roof, called the paranginan roof, a multi-storey roof. The more engravings and tidiness of home making depict, the higher the level of the social status of the building owner.
Songs in the Teaching of Listening for Elementary School Students
Authors: Hadijah Sitti
Published: January 2023

Lack of motivation among students may cause teachers to be less successful in teaching a foreign language. To help the students to be motivated in listening, the teacher should find an appropriate technique to apply in teaching listening. Generally, the children like listening to song because they like something cheerful. If they feel happy, they will do it over and over again. If the students enjoy listen to the songs, they will enjoy learning listening by using the song, too. Promoting the students to love learning English will motivate to study. Songs are authentic materials and can make the students fun. Songs as media are very useful to help students improve their motivation. By enhancing the students’ motivation, the English teachers have a chance to enhance the students’ listening achievement by using the songs in the classroom learning.
AVIAN AND PLANT DIVERSITY AND THEIR INTER-RELATIONSHIP FROM TULJARAM CHATURCHAND COLLEGE CAMPUS, BARAMATI, DISTRICT PUNE (M.S.) INDIA
Authors:   Assistant Professor, Post Graduate, Department of Zoology, Tuljaram Chaturch and College of Arts, Science and Commerce, Baramati, Pune, Maharashtra., B. Nale Vitthal
Published: January 2023

The Plant and bird diversity composition of Tuljaram Chaturchand College Campus was investigated to ascertain the ecological status. The study identified 740 plants. The plant species composition was dominated by major trees having 545 plants, followed by 178 shrubs, 12 herbs and 05 other grasses with parasitic plants. In relation with different plant species, the campus was found to attract 24 bird species. Asian Koel, Crows, Sparrows, Rock Pigeon, Red vented bulbul, Spotted owlet, Green bee eater, Sun birds, Drongo, etc. they were dominantly found throughout the year. The college campus is very beautiful because of attraction of various birds and plants.
SOFT TISSUE CALCIFICATIONS : ASERIES OF FOUR CASES
Authors: Pagare Jaishri , N.S Anza
Published: January 2023

Heterotrophic calcificationsare pathologic calcifications of the soft tissue regiondue to any chronic inflammatory cause(dystrophic calcification) or by hypercalcemic states in the body(metastatic calcification) or due to any idiopathic cause. It is usually detected as an incidental finding and rarely appears symptomatic. Here we are presenting fewcase reports of patients with soft tissue calcifications that reported to the department of Oral Medicine andRadiology.
A STUDY TO ASSESS THE OCCURRENCE OF ASTHMA AND ITS RISK FACTORS AMONG CHILDREN WITH RESPIRATORY SYMPTOMS IN A SELECTED DISTRICT HOSPITAL OF WEST BENGAL
Authors: Maji Tannistha , Adhikary Smt. Mitali
Published: January 2023

Objective: Asthma is the most common chronic childhood disease being increasingly diagnosed in recent years. The objective of study was to determine the occurrence and risk factors of asthma and their association. Methods: The conceptual model adopted was based on epidemiological triad. Consecutive sampling technique was done to select 203 children of age group 6to 12 years attending OPD in Diamond Harbour District Hospital. The measuring tool used were record analysis, structured and semi structured interview schedule and physical assessment recording proforma. Validity of tool was done by seven experts. Reliability was established by inter rater method. Results: The occurrence of asthma was 21.2%. On analysis among risk factors exposure to tobacco smoking during pregnancy (OR 3.76), needed NICU admission(OR 3.1) low birth weight (OR 3.58),first born child(OR 2.5), hospitalization before 2 yrs of age due to RTI(OR 9.76), family H/O different allergic symptoms (OR 6.31), family H/O of asthma (OR 14.29), residence near busy road (OR 2.25) and industrial area (OR 5.02), overcrowding (OR 2.22), damp in bedroom (OR 2.02) presence of domestic animal (OR 2.72) had significant association. Smoke producing and mixed type cooking fuel (OR 7.46), overweight (OR 12.8), seasonal variation (OR 12.1) and different triggering factors (OR 17.59) were significantly associated. Conclusions: The occurrence of asthma was 21.2% which was much higher than previously reported. Age group 6-9 yrs was commonly affected. In this study males (26%) had higher asthma occurrence than the females (13.8%) and it was statistically significant (p=0.037).). The male: female ratio is 1.26: 1. Family history of asthma or allergy, previous hospitalization due to RTI, exposure to smoke and smoking were found to be significant risk factors for development of asthma.
AN ASSESSMENT OF SOUTH ASIAS ENVIRONMENTAL POLITICS
Authors: a Deepika
Published: January 2023

Environmental politics is a relatively new and evolving trend in world politics, yet it has far-reaching significance and consequences. It emerged in the 1970s, and it has completely revolutionized the global political scenario. South Asia today is much more prone to climate change and global warming than ever. Reports alarmingly suggest that cities such as Karachi, Mumbai, and Maldives are under the immediate threat of being drowned by 2050, if the sea level keeps rising due to the melting of glaciers. Environmental challenges in South Asia range from air pollution, water scarcity, land degradation, deforestation, flood, drought, cyclones, marine ecology to a comprehensive loss of biodiversity. Unfortunately, however, it seems that environmental issues are not one of the primary concerns in South Asia, for the region is still struggling to ensure the basic necessities of life and a humane society â€“ the necessities such as food, shelter, employment, health, education, and so on.This paper assesses South Asias environmental politics. The papers findings advocate that there is a pressing need to develop and implement environmentally oriented political programs before it is too late in the region.
MISE AU POINT SUR LA PRISE EN CHARGE DE LHEMORRAGIE DE POST-PARTUM
Authors:   Gynecology and Obstetrics Department at Mohammed VI University Hospital of Oujda., Stimou Sanae , Taheri Hafsa ,   Gynecology and Obstetrics Department at Mohammed VI University Hospital of Oujda., Saadi Hanane ,   Gynecology and Obstetrics Department at Mohammed VI University Hospital of Oujda., Mimouni Ahmed ,   Gynecology and Obstetrics Department at Mohammed VI University Hospital of Oujda.
Published: January 2023

Lhemorragie du post-partum, definie par un saignement de plus de 500 ml dans les 24 heures qui suivent laccouchement, est une complicationgrave engageant rapidement le pronostic vital de la femme. Sa prise en charge doit etre multidisciplinaire. Elle repose sur des protocoles de soins chronometres partages au sein des reseaux de soins. Sont realises en parallele les gestes obstetricaux (delivrance artificielle, revision uterine et de filiere), ladministration duterotoniques (ocytocine et prostaglandines), le remplissage vasculaire et la transfusion ainsi que le traitement des anomalies de lhemostase. Lhemostase mecanique fait appel a la ligature ou a lembolisation des arteres uterines et a lhysterectomie dhemostase en dernier recours. Les conditions du transfert dune patiente vers un centre de radiologie interventionnelle ou un service de reanimation doivent etre pesees en fonction des conditions hemodynamiques de la patiente.
INSTITUTES CONTRIBUTION TO THE MEDICINE OF HIPPOCRATES, GALEN, AND IBN SINA
Authors:   Ibn Sina Institute of Tibb, Johannesburg, South Africa., Bhikha Rashid
Published: January 2023

The training of doctors in this system of medicine in South Africa, was introduced by the Ibn Sina Institute of Tibb under the name of Tibb (Arabic word for Medicine), after obtaining academic support from universities in India and Pakistan, where this system is trained and practiced under the name of Unani Medicine. The Institute identified concerns with respect to the terminology of humours, the limited information on identifying temperament with respect to predisposition to illness conditions as well as the lack of relationship between the principles of physis, temperament, humours, and lifestyle factors. This paper highlights the contribution of the Institute, based on various research projects conducted between 2003 and 2020. The results of the research projects contributed positively to the humoral and temperamental theories as well as the relationship between an individual and the environment within the context of Lifestyle Factors. More significantly the relationship between the principles of physis, humours, temperament, and lifestyle factors within the context of aetiology, pathology, diagnosis, and treatment have also been clarified. The Institutes contribution to this system of medicine has facilitated the development of the training material at both a 5-year Undergraduate Degree and a 1-year Postgraduate Diploma (for diagnostic healthcare professionals) to be trained as doctors of the Medicine of Hippocrates, Galen, and Ibn Sina Ã¢Â€Â“ also known as Tibb.
“RİNDİN DİNİ” Rint-Zahit Çatışmasının Dinî Yönü
Authors: GÜMÜŞ Mustafa Yunus
Published: January 2023

Dinî kurallar, toplumun sosyokültürel unsurlarıyla sentez oluşturarak bireylerin hayatlarını kontrol eder ve en az sosyal normlar kadar etkili olup yaptırım gücüne sahiptir. Bu normları sosyal normlardan ayıran en önemli unsur, dinî normların kaynağının ilahi olması ve yerine getirmeyenlerin suç işlemekle birlikte ilahi emirlere aykırı davrandığı için günahkâr olarak değerlendirilmesidir. Divan şairleri tarafından idealize edilmiş rint ile şairlerin sevmediği, aşağıladığı zahit tipi arasında büyük bir mücadele vardır. Onlar arasındaki çatışmasının birçok yönü bulunmakla birlikte dine bakışlarındaki farklılık, aralarındaki çatışmanın önemli nedenlerindendir. Bir yanda kurallara mesafeli duran rint, diğer yanda emir ve yasaklara körü körüne bağlı olan zahit bulunmaktadır. Divan şiirinin birbirinden ayrılmaz iki tipi arasındaki bu kargaşa, birçok divan şairinin şiirlerinde yerini almıştır. Çalışmamızda rint ve zahit arasındaki çatışmanın dinî nedenleri örnek beyitler ile açıklanacaktır.
International Cooperation During the Covid-19 Pandemic Crisis: A Realist Analysis
Authors: ÇATAKLI Ahmet Onur , KAYA Emirhan
Published: January 2023

Although COVID-19 has brought about a global health crisis that does not recognize national borders and requires a strong international cooperation, contrary to expectations, the world actors could not achieve international cooperation. States have acted in a selfish way by ignoring the needs and concerns of other countries and tried to foster their role and power in the international system. Consequently, this situation has made this study to use the assumptions of realist theory of International Relations regarding anarchy, self-interest, distribution of powers and so on. In this article, it is concluded that the conditions and motives expressed by these concepts have made the states tend to protect themselves and increase their power instead of focusing on cooperation during the health crisis. Additionally, the current situation in distribution of power, which refers to the bipolarity between the US and China has remained in effect.
Restoran İşletmecilerinin Hayalet Mutfak Girişimine Yönelik Bakış Açılarının Belirlenmesi: Gaziantep İlinde Nitel Bir Uygulama
Authors: BALTACI Furkan , YILDIZ Ali
Published: January 2023

Bu çalışma yeni bir fenomen olarak yükselişini sürdüren hayalet mutfak girişimini restoran işletmesi sahipleri ve yöneticilerinin bakış açısıyla değerlendirmeyi amaçlamaktadır. Bu kapsamda 2015 yılında UNESCO tarafından yaratıcı şehirler ağına dâhil edilen Gaziantep ili araştırmanın evreni olarak belirlenmiştir. Destinasyonda faaliyet gösteren turizm işletme belgeli 23 restoran işletmesinden çalışmaya katılmayı kabul eden 18’i araştırmanın örneklemini oluşturmuştur. İşletme sahibi ve yöneticileri ile 6 açık uçlu soru üzerinden derinlemesine mülakatlar yapılmıştır. Çalışmada elde edilen sonuçlar, hayalet mutfağın fiziki alandan bağımsız olmasının otantiklik ve üretici-tüketici iletişimi açısından önemli zayıflıklar içerdiğini göstermiştir. Bir diğer zayıflık ise tüm sürece ilişkin kalite algısının zamanında ve eksiksiz teslimat üzerinde şekillenmesidir. Tüketiciye ulaşım, reklam, kurumsallaşma motivasyonu ve fiziki yatırım maliyeti avantajı ise sistemin güçlü yanları olarak değerlendirilmiştir.
CDS Primleri ile Yabancı Pay Senetleri Yatırımları Arasındaki İlişki: Türkiye Örneği
Authors: ŞENOL Zekai , GÜLCEMAL Tuba , KOÇ Selahattin
Published: January 2023

Finansal varlıklar içinde pay senetleri riskli varlıklardır ve yabancı pay senedi yatırımcıları yatırımla ilgili risk değerlemesi yaparak yatırım kararı vermektedirler. Kredi risk primleri finansal araç, firma ve ülke risklerinin göstergesi olarak finansal piyasalarda yaygın olarak kullanılmaktadır. Bu çalışmada, kredi risk prim göstergesi olan kredi temerrüt takasları (CDS) ile yabancı pay senetleri yatırımları arasındaki ilişki araştırılmıştır. Çalışmada, 11 Eylül 2020 – 24 Haziran 2022 döneminde, Türkiye’ye ait 5 yıllık CDS primleriyle yabancı pay senetleri yatırımları verileri kullanılarak Fourier Granger nedensellik analizi gerçekleştirilmiştir. Çalışmada CDS’ler ile yabancı pay senetleri yatırımları arasında tek yönlü yani CDS primlerinden yabancı pay senetleri yatırımlarına doğru bir nedensellik tespit edilmiştir. Elde edilen sonuçlar, yatırımcılar, işletmeler, ekonomik ve finansal karar alıcıları açısından kullanılabilirlik taşımaktadır.
Assessment of change in forests land, carbon stock and carbon emissions of KPK, Pakistan for past three decades using geospatial techniques
Authors: Goheer Muhammad Arif , Fatima Laraib , Farah Humera , Hassan Sher Shah , Abbas Nazir
Published: January 2023

Reducing emissions from deforestation and forest degradation is a mechanism to cut down GHG emissions and protect the threatened forest ecosystems. Pakistan is suffering from high forest degradation and deforestation rates, but recent plantations under BTTAP have created a significant impact. This study was designed to identify the LULC changes, forest sequestration and emissions from forest degradation in the forest hub districts (Malakand, Mardan, Lower Dir and Upper Dir) of KPK, Pakistan using Landsat imageries. LULC changes were analyzed from 1990 to 2020. In addition, the amount of carbon sequestration and emissions from forest degradation were also calculated. Results of the analysis showed forest area reduction from 1990 to 2009, followed by a sharp increase in the next decade (2010–2020) by 56%. Around 836 km2 of land was found to be covered with forests during BTTAP. The net change was a 32% increase in forest land over three decades. The study offers important information which environment managers and decision-makers can utilize to encourage the plantation of trees and save existing forests in the country to combat climate change.
Estado do conhecimento
Authors: Alves Vasconcelos Clenya Ruth , Ximenes-Rocha Solange Helena
Published: January 2023

Neste trabalho de natureza bibliográfica, do tipo “estado do conhecimento” nos propomos a analisar o que revela o mapeamento das produções acadêmicas sobre comunidades colaborativas de aprendizagem docente na formação de professores no período de 2016 a 2021. A investigação elegeu 25 pesquisas (16 dissertações e 9 teses). Usamos como fonte de pesquisa os descritores “Desenvolvimento Profissional Docente em Grupos Colaborativos” e “Desenvolvimento Profissional Docente em Comunidades Colaborativas” no banco de dados da Capes e da Biblioteca Brasileira de Teses e Dissertações. Como resultado, observa-se que as comunidades colaborativas qualificam a formação docente. Emerge como um novo problema a ser investigado, a dimensão da formação inicial dos cursos de formação de professores no interior dessas comunidades. A maioria dos estudos na área foca-se no âmbito continuado da formação docente. O principal desafio enfrentado por muitos pesquisadores da área é instituir uma postura investigativa nas comunidades de colaboração de aprendizagem docente.
QUALIDADE ESPACIAL A PARTIR DA PERCEPÇÃO DO OBSERVADOR EM MOVIMENTO
Authors: Grub Julian , Souza Silva André , Colusso Izabele , Neckel Alcindo , Liell William
Published: January 2023

A avaliação da qualidade do ambiente construído se justifica, nesse estudo, através do entendimento da forma de apropriação dos espaços pelos indivíduos. Através da experiência do espaço, a pesquisa busca entender durante o percurso do observador, a realidade vivenciada do projeto. Esses registros, realizados durante o processo de observação das arquiteturas de conexão, possibilitam o entendimento das alterações do uso e apropriação espacial não planejados. O objetivo geral deste manuscrito é refletir sobre os usos arquitetônicos predefinidos, ligados à infraestrutura, como pontes, passarelas e viadutos, tendo como estudo a Estação Metroviária Niterói, localizada na cidade de Canoas/RS - Brasil. O método utilizado teve como base a elaboração de diagramas de percursos e registro realizados em linhas de deslocamentos, por meio da percepção do observador em movimento. Os resultados demonstraram que as arquiteturas de conexão, como obras de infraestrutura, mesmo ligadas as questões utilitárias e de eficiência urbana, podem permitir maior interação e maior grau de comodidade e acolhimento, incorporando novos usos e atividades não previstos inicialmente no projeto.
Can Brain-derived Neurotrophic Factor (BDNF) Mimetics be a Way Out for
Neurodegenerative Diseases?
Authors: Korkmaz Orhan Tansel
Published: January 2023

Neurodegenerative diseases are chronic and progressive disease groups characterized by the decline
of neural transmission because of the loss of structure and function of neurons. Although there is currently no
effective treatment for neurodegenerative diseases, new treatment strategies need to be developed urgently.
Among neurotrophins, BDNF has been extensively investigated, and it has emerged as an important regulator
of synaptic plasticity, neuronal survival, and differentiation. Changes in BDNF levels and signaling pathways
have been identified in several neurodegenerative diseases. Moreover, promising results have been obtained for
BDNF in many experimental studies on animal models. In addition, BDNF serves as a crucial molecular target
for developing drugs to treat neurological diseases. However, several pharmacokinetic difficulties have limited
its use in clinical practice, such as its inability to cross the blood-brain barrier, short half-life, and potential adverse
effects. To avoid these difficulties, several approaches have been explored, but they have led to disappointing
results. One way to overcome the limitations of BDNF may be with mimetic molecules that can effectively
stimulate the receptors it has an affinity with and thus activates BDNF pathways. In this perspective article,
an evaluation of the efficacy of different BDNF mimetics against neurodegenerative diseases was made.
Artificial Intelligence in Breast Cancer: A Systematic Review on PET
Imaging Clinical Applications
Authors: Alongi Pierpaolo , Rovera Guido , Stracuzzi Federica , Popescu Cristina Elena , Minutoli Fabio , Arnone Gaspare , Baldari Sergio , Deandreis Désirée , Caobelli Federico
Published: January 2023

Background:

18F-FDG PET/CT imaging represents the most important functional imaging
method in oncology. European Society of Medical Oncology and the National Comprehensive Cancer
Network guidelines defined a crucial role of 18F-FDG PET/CT imaging for local/locally advanced
breast cancer. The application of artificial intelligence on PET images might potentially contributes in
the field of precision medicine.

Objective:

This review aims to summarize the clinical indications and limitations of PET imaging for
comprehensive artificial intelligence in relation to breast cancer subtype, hormone receptor status, proliferation
rate, and lymphonodal (LN)/distant metastatic spread, based on recent literature.

Methods:

A literature search of the Pubmed/Scopus/Google Scholar/Cochrane/EMBASE databases
was carried out, searching for articles on the use of artificial intelligence and PET in breast tumors. The
search was updated from January 2010 to October 2021 and was limited to original articles published
in English and about humans. A combination of the search terms "artificial intelligence", “breast cancer”,
“breast tumor”, “PET”, “Positron emission tomography”, “PET/CT”, “PET/MRI”, “radiomic”,"
texture analysis", “machine learning”, “deep learning” was used.

Results:

Twenty-three articles were selected following the PRISMA criteria from 139 records obtained
from the Pubmed/Scopus/Google Scholar/Cochrane/EMBASE databases according to our research
strategy. The QUADAS of 30 full-text articles assessed reported seven articles that were excluded for
not being relevant to population and outcomes and/or for lower level of evidence. The majority of papers
were at low risk of bias and applicability. The articles were divided per topic, such as the value of
PET in the staging and re-staging of breast cancer patients, including new radiopharmaceuticals and
simultaneous PET/MRI.

Conclusion:

Despite the current role of AI in this field remains still undefined, several applications for
PET/CT imaging are under development, with some preliminary interesting results particularly focused
on the staging phase that might be clinically translated after further validation studies.
The Comparative Genomics and Network Analysis of eNOS by Using
Different Bioinformatics Approaches
Authors: Banerjee Arpita , Singh Randeep , Arora Nymphaea , Arora Tania , Prashar Vikash , Godara Priya , Sharma Arti , Changotra Harish , Parkash Jyoti
Published: January 2023

Background:

Nitric oxide synthase (NOS) is an enzyme that catalyzes the synthesis of
nitric oxide (NO) from L-arginine. It has three isoforms- (i) neuronal NOS (nNOS or NOS1), which
participates in neural transmission; (ii) inducible NOS (iNOS or NOS2), which produces NO in
macrophages; and (iii) endothelial NOS (eNOS or NOS3) that regulates blood pressure. The eNOS is
mainly expressed in blood vessels and is a crucial regulator of endothelial homeostasis.

Objective:

The present study aimed to unravel the role of eNOS in different signaling pathways and its
involvement as a therapeutic target in various neurodegenerative disorders.

Methods:

This study used various in silico methods for comprehensive genomic analysis of eNOS in
16 organisms from 7 different phyla. Prediction of conserved domains and evolutionary relationship
for eNOS among 16 organisms was made. Various physical and chemical parameters, signal peptides,
and transmembrane regions that helped understand its functional relevance were also studied.

Results:

Three transcription factor binding sites (TFBS), i.e., CP2, AR, and LDSPOLYA, were
identified in human eNOS, while ATF1, T3R, and STAT1 were predicted in mouse eNOS.
Transcription factors were identified for each regulatory region in human as well as mouse eNOS.
eNOS protein was predicted to harbor 14 different post-translational modification (PTM) sites, most
of which have phosphorylation (serine followed by threonine and tyrosine phosphorylation) followed
by sumoylation and palmitoylation among all the organisms used in the current study. However,
human eNOS has a relatively lower number of PTM sites for tyrosine phosphorylation.

Conclusion:

Structures of eNOS isoform, consistent with available biochemical and structural data,
provide substantial insight into the NOS conformational changes, which give in-depth knowledge of
the mechanism of eNOS, and will be helpful for better understanding the role of eNOS in
pathophysiology.
Tumour DNA Sequencing
Authors: Islam Farhadul
Published: January 2023

Cancer pathogenesis is a multistep process involving the accumulation of
complex genetic and epigenetic alterations. The disease can be sporadic or familial in
nature. The genes associated with much familial cancer or inherited cancer susceptible
syndrome have already been identified. Thus, genetic testing for pathogenic variants of
these genes could predict whether an individual has a high risk of developing cancer in
their lifetime. Also, tumour DNA sequencing in patients with cancer can be used for
therapy selection and to predict treatment outcomes. The recent development of high
throughput sequencing enables the exploration of whole genome profiling, including
mutations, structural variations, transcriptomes, splicing events, etc., in patients with
cancer, thereby providing guidelines for personalized precision medicine in clinical
practice. However, the translation of cancer genome sequencing information into the
clinical treatment plan is highly complicated, needs multidisciplinary expert panels and
is not cost-effective for mass application. Further development in sequencing analysis
and data interpretation are imperative for point-of-care settings applications. This
chapter outlines the clinical significance of tumour DNA testing and genomic
sequencing in various cancers.
Circulating Tumour Cells in Solid Cancer
Authors: Aktar Sharmin , Cheng Tracie T. , Gamage Sujani M. K. , Gopalan Vinod , Islam Farhadul
Published: January 2023

Circulating tumour cells (CTCs), as 'liquid biopsy”, has a major benefit over traditional tissue biopsy and has the potential to become a less invasive and more costeffective cancer biomarker. The presence of CTCs in the circulation indicates the presence of a tumour and the possibility of metastatic spread. Hence, the characterisation of CTCs is expected to provide crucial insights into the mechanisms of metastasis. It can also provide useful information about the future use of CTCs as a surrogate endpoint biomarker in diagnosis, prognosis, and treatment response prediction by minimizing the limitations of tissue biopsies. Also, it provides a new horizon for the development of novel targeted therapies. However, the lack of specific and effective methods is the key limitation in CTC detection and isolation in patients with cancer. Therefore, more responsive methods and approaches may be needed to improve the accuracy of CTC measurements. Herein, this book chapter will provide a current picture of CTCs as surrogate biomarkers for disease diagnosis, prognosis and predicting therapy response, along with the risk of relapse in cancers.
Electrochemical Biosensor for Cancer Biomarkers Detection
Authors: Arifuzzaman Md , Kamal Masud Mostafa , Ahmed Asif , Morsaline Billah Md , Nazmul Islam Md
Published: January 2023

Biosensors are common analytical devices, capable of sensing a myriad of
biological analytes, including cancer biomarkers. Although biosensors have different
transducer types, electrochemical biosensors provide fast analysis time, high
sensitivity, and the ability to perform complex measurements such as multiplexed
analysis or screening tests for early diagnosis and prognosis of cancer. This chapter
describes the background and theory of electrochemical sensors and introduces the
main readout techniques. Innovative electrochemical biosensing strategies for analysis
and quantification of important early cancer biomarkers, which include circulating
nucleic acids (e.g., circulating tumour DNA, gene mutations, and microRNA) proteins,
circulating tumour cells, and extracellular vesicles are discussed with the recent
developments to provide an overview of the possible academic and clinical approaches
Imagens da língua e cultura portuguesas de falantes de português língua de herança nos Estados Unidos e e Canadá
Authors: Oliveira Beatriz
Published: January 2023

The images that individuals create of languages, people and cultures tend to refl ect their own communication and educational behaviours. These images can originate stereotypes, i.e., static, decontextualized, simplifi ed, and abbreviated images, present in common memory and accepted by particular groups (Castellotti & Moore 2002). Therefore, the diagnosis of images and perceptions that heritage language speakers associate with language and culture can enhance educational activity, particularly the comprehension of their directions and motivations, the adaptation of the teacher’s speech in classroom, as well as the creation and selection of didactic materials that aim to contribute to the (re)perspectivation of negative images or stereotype deconstruction. The main purpose of the present study is to diagnose and analyse quantitatively and qualitatively the images that heritage speakers of Portuguese language in North America possess of the Portuguese language and culture. To collect data, we created an anonymous online questionnaire composed of 19 questions signifi cantly related to the respondents’ contact with the language and Portuguese communities, as well as their perceptions of Portuguese population, language and culture. The questionnaire was taken by 10 heritage speakers (belonging to the second and third generation of Portuguese emigrants) who reside in the United States and Canada, countries with a signifi cant presence of Portuguese communities. The data reveals a collective thought of the respondents, composed of homogenous, crystallized, and stereotyped images regarding the Portuguese language and its utility, as well as its people and culture
Ensino para surdos no Brasil no século XX contribuições de educadores para a área
Authors: Anachoreta Vanessa Gomes Teixeira
Published: January 2023

The development of the education of the Deaf begins in the 15th century, when the fi rst educators – preceptors, religious and doctors - sought to teach the oral and/or written language so that the Deaf of the nobility could be recognized by the law and inherit titles. In the brazilian context, the presenceof educators since the foundation of the Instituto Imperial dos Surdos-Mudos de Ambos os Sexos in 1857 was also fundamental for the formulation and development of the fi eld. In order to deepen this dynamic, the current work aims to present a global view of how education for the deaf was organized in Brazil in the 20th century and how educators infl uenced this scenario. The research was guided by the theoretical perspective of Linguistic Historiography and, in dialogue with the ideas of Swiggers (1990), its analysis was guided by the sociological model, as it seeks to understand the social context of the period studied and the relations between the social groups that acted, in diff erent ways, in pedagogical practices aimed at the Deaf in Brazil throughout the 20th century. It is observed that, in addition to deepening questions about the area with their investigations, educators were also important agents in the consolidation of pedagogical practices - either to reinforce the method defended by the intellectual ideas of the period, or to propose measures of resistance and others methodologies
A compreensão da leitura na escola uso e consciência no uso de guessing game
Authors: Borges Caroline Bernardes , Baretta Danielle , Pereira Vera Wannmacher
Published: January 2023

e article has as its theme the understanding of reading poems at school, considering its teaching, focusing on the use and awareness of the use of the guessing game by students at the end of Elementary School I. It is the purpose of the authors, given their history of actions associating universities and schools, collaborate for children to learn to read, providing theoretical knowledge from Psycholinguistics in interfaces and proposals for application in school teaching. In order to do so, the article fi rst off ers an exposition on the context of learning to read, evidencing the diffi culties of children in this context and the relationship with teaching. In the following, theoretical foundations on the psycholinguistic topics of reading mentioned above are exposed, so that professionals and students in professional preparation can analyze and deepen them considering their reading tasks. Subsequently, proposals for teaching reading at school are presented, applying these fundamentals in practical activities of guessing game in the reading of poems by authors with recognition in the history of literature for children. At the end of the article, fi nal comments are presented on the article, its organization and its contribution to the fi eld of studies and to the teaching of reading at school. Thus confi gured, the article in its foundations and its pedagogical application contributes to the advancement of the psycholinguistic fi eld in interfaces and to the teaching of reading at school insofar as it provides a theoretical-methodological path of scientifi c-pedagogical basis of use and awareness in use from the guessing game to be better known and more experienced
THE RELATIONSHIP BETWEEN PARENTS SUPPORT AND LEARNING MOTIVATION IN ADOLESCENTS DURING THE PANDEMIC PERIOD AT SMPN 2 PULE TRENGGALEK
Authors:   Universitas Brawijaya, Rohmahwati Hidah , Hayati Yati , Kristianingrum Niko
Published: January 2023

The Covid-19 pandemic has an impact on all aspects of life, including the implementation of learning activities that are changed from face-to-face to distance learning. Distance learning requires student independence which needs to be encouraged by a high motivation to achieve learning success. Parents as a substitute for teachers at home are expected to provide optimal support so that adolescents have high motivation to learn while participating in learning activities. This study aims to determine the relationship between parental support and learning motivation in adolescents during the pandemic period at SMPN 2 Pule Trenggalek. This was an observational study using a cross-sectional design. Respondents in this study are students of SMPN 2 Pule Trenggalek Class VIII and IX, totaling 142 students, who are selected based on simple random sampling techniques. This study uses an online questionnaire about parental support and student motivation during the pandemic as a means of collecting data. The results showed the majority of parental support was in the high category (95.8 %), and the respondents learned motivation was in the medium category (54.2%). The results of data analysis using the Spearman rank obtained a correlation value of 0.361 with a p-value of 0.000 so that Ho was rejected (<0.05). The study concludes that there is a relationship between parental support and learning motivation in adolescents during distance learning in the pandemic period at SMPN 2 Pule Trenggalek. Further research can be carried out related to parental support provided to adolescents during the pandemic with parents as respondents so that the data obtained will be comprehensive.
ANALYSIS OF THE USE OF MENSTRUAL PAD, TAMPONS, AND MENSTRUAL CUP DURING MENARCHE
Authors:   Universitas Brawijaya, Warashinta Dewi , Astari Asti , Merdikawati Ayut
Published: January 2023

Various kinds of alternative product innovations have beenÂ to substitute disposable sanitary napkins for reducing the increasing waste of disposable sanitary napkins and reduce environmental pollution. The products in question include, among others, menstrual cups, tampons. Tampons and menstrual cups are still rarely used by Indonesian women because there is little knowledge about menstrual hygiene and how to use them are still considered taboo. The objective of the study is to compare the analysis of the use of sanitary napkins, tampons, and menstrual cups during menarche. The method used in this study is a literature study from the journal published in 2015-2020. The database was from Ebsco, ProQuest, and Science Direct database, and 231 articles were obtained and filtered so that the final result were 12 articles that matched. The results of the comparison of the use of sanitary napkins, tampons, and menstrual cups in terms of hygiene and safety, environmental impact, and effectiveness showed that menstrual cups were superior to the other two products. In conclusion, the alternatives menstrual sanitation tools besides sanitary napkins are tampons and menstrual cups.Â Â This paper can be the basis for further research using different research designs to obtain more complete data.
Recomendaciones para el manejo de la nutrición en banano y plátano
Authors: Bolaños Benavides Martha Marina , Yacomelo Hernández Marlon José , Leon Pacheco Rommel Igor
Published: January 2023

El video presenta recomendaciones sobre el manejo de la nutrición de banano y plátano, las estrategias de diagnóstico para el manejo de la fertilidad del suelo: 1) identificación de síntomas de deficiencia y toxicidad ocasionados por los nutrientes, 2) Análisis de suelos y foliares: muestreo, calibración e interpretación y 3) extracción de nutrientes por la fruta.
Requerimientos hídricos del cultivo de banano y plátano
Authors: Bolaños Benavides Martha Marina , Yacomelo-Hernandez Marlon José , Leon Pacheco Rommel Igor
Published: January 2023

El video presenta recomendaciones sobre diferentes estrategias de manejo eficiente del agua, entre ellas la cuantificación de las necesidades hídricas en función de 1) estado hídrico del suelo, 2) balance hídrico suelo – planta - atmósfera.
Información agroclimática para la toma de decisiones sobre el manejo agronómico del cultivo
Authors: Bolaños Benavides Martha Marina , Yacomelo Hernández Marlon José , Leon Pacheco Rommel Igor
Published: January 2023

El video presenta la influencia de las variables climáticas sobre las variables asociadas a la productividad y las recomendaciones para el manejo del cultivo en función de las condiciones climáticas predisponentes.
Uso de aplicación AHoRa
Authors: Bolaños Benavides Martha Marina , Yacomelo Hernández Marlon José , León Pacheco Rommel Igor
Published: January 2023

Descripción del video: el video presenta recomendaciones para el uso de una aplicación móvil que permite mejorar la planificación y toma de decisiones de prácticas agronómicas en plantaciones de musáceas (plátano y banano) frente a la variabilidad climática, con especial referencia en la agricultura familiar de Colombia, Perú y República Dominicana.
Diversificación de productos: agroindustrialización del sabajón de guayaba
Authors: Prada Forero Luz Esperanza , López González Ximena
Published: January 2023

Agrosavia ofrece a productores y agroindustriales e inversionistas el sabajón de guayaba. El proceso cuenta con tecnología asequible de baja inversión del que se obtiene una bebida alcohólica con una aceptación del 92% formulada y estandarizada por la NTC 2972.
Composición funcional de té herbal de guayabo (Psidium guajava L.)
Authors: Prada Forero Luz Esperanza , Deantonio Florido Leidy Yibeth , Plazas Ordoñez Mónica Idali
Published: January 2023

El estudio de la composición funcional del té herbal de guayabo busca mejorar el proceso y la calidad de esta reciente opción de agroindustria del cultivo. A través de esta opción se ofrece un producto que facilita la tradición de usar las hojas de guayaba en infusión o tisana para aliviar una gran variedad de dolencias.