bluuebunny/crossref_metadata_2025 huggingface dataset:
An innovative approach to managing the interest margin: economic and statistical analysis of the resource base of a commercial bank
Authors: Andros Svitlana , Andros Svitlana , CHANG Shichao
Published: April 2021

The dynamics of interest income, that is, the difference between the average rates on active and passive operations of the bank, has been analyzed. It was found that the increase in the share of term deposits in the total amount of the bank's mobilized resources is positive, despite a temporary decrease in net income from bank interest. It has been substantiated that the deposits of legal entities are a stable part of the attracted resources. Long-term deposits allow lending for long periods and at high interest rates. The purpose of the article is to improve an innovative approach to managing the interest margin based on the economic and statistical analysis of the bank's resource base. Literature processing shows that banks pay insufficient attention to the methodology for assessing interest income. The relevance of the article is determined by the value of interest income as one of the main factors that determine the profitability of the bank's lending operations. The methods of comparison, grouping, detailing of final indicators, calculation of relative and average values are used. The scheme of the bank interest margin management process is proposed. Calculated the average size of credit investments, the total amount of assets. The average price of credit resources was calculated based on the price of a particular type of resource and its share in the total amount of funds mobilized by the bank. The average level of interest on active and passive operations of the bank was determined based on the received interest income. The size of interest income, trends and factors of its change have been determined. The indicator of the minimum interest income was calculated on the basis of which the bank covers expenses, but does not ensure profit. The level of profitability of bank loan operations has been determined. It has been established that a change in interest income can be caused by an increase or decrease in rates on active operations of the bank, interest on attracted resources and the share of the latter in the total volume of credit investments. The average real price of demand deposits and time deposits attracted by the bank was determined on the basis of the market price of these resources and adjustments for the rate of the required reserve deposited with the NBU. A mechanism for the formation of bank interest income is proposed. The expected size of the minimum profit margin and the level of profitability of the bank's lending operations are presented. The approximate minimum price of credit investments was determined based on the level of costs and the pledged amount of profitability of the bank's lending operations for the coming period. The possibility of reducing the spread of rates of attraction and rates of placement of resources in the bank through the use of the proposed funding mechanism has been scientifically substantiated.
Adapting Russian Accounting to the International Standards: Models, Algorithms, and Amendments
Authors: Troitskiy Aleksandr , Blizkiy Roman , Rakhmeeva Irina
Published: April 2021

The article deals with the impact of the Covid19 pandemic on accounting and financial reporting in terms of the presentation of certain items in the income statement, the assessment of accounting judgments, key sources of uncertainty, and business continuity assumptions. The research focuses on the features of amendments, algorithms, and principles for implementing the provisions of IFRS in 2020: IAS (1) The authors proposed an algorithm for transforming (adapting) financial statements from RAS to IFRS. The article, systematized the approaches representing the key areas in the adaptation of the relationships that create the accounting environment for the successful implementation of the objectives of the transition to IFRS. An integrated approach to the adaptation stages takes into account the external and internal environment of the elements of the transformation of financial statements.  The stages interact and are set up for the result of a successful transition to the formation of financial statements in accordance with IFRS. The authors note that the factors affecting the efficiency, reliability and high operational effect of the stage depend on many variables.  The authors have developed a model of procedures for accounting and control assessment of elements compatibility for the adapting, and unifying stage of transition from RAS to IFRS.
Subarcsecond Mid-infrared View of Local Active Galactic Nuclei. IV. The L- and M-band Imaging Atlas*
Authors: Isbell Jacob W. , Burtscher Leonard , Asmus Daniel , Pott Jörg-Uwe , Couzy Paul , Stalevski Marko , Gámez Rosas Violeta , Meisenheimer Klaus
Published: April 2021

We present the largest currently existing subarcsecond 3–5 μm atlas of 119 local (z < 0.3) active galactic nuclei (AGNs). This atlas includes AGNs of five subtypes: 22 are Seyfert 1; five are intermediate Seyferts; 46 are Seyfert 2; 26 are low-ionization nuclear emission regions; and 20 are composites/starbursts. Each active galactic nucleus was observed with the Very Large Telescope Infrared Spectrometer and Array Camera (ISAAC) in the L and/or M bands between 2000 and 2013. We detected at 3σ confidence 92 sources in the L band and 83 sources in the M band. We separated the flux into unresolved nuclear flux and resolved the flux through two-Gaussian fitting. We report the nuclear flux, extended flux, apparent size, and position angle of each source, giving 3σ upper limits for sources that are undetected. Using Wide-field Infrared Survey Explorer (WISE) W1- and W2-band photometry we derived relations predicting the nuclear L and M fluxes for Sy1 and Sy2 AGNs based on their W1–W2 color and WISE fluxes. Lastly, we compare the measured mid-infrared colors to those predicted by dusty torus models SKIRTOR, CLUMPY, CAT3D, and CAT3D-WIND, finding the best agreement with the latter. We find that models including polar winds best reproduce the 3–5 μm colors, indicating that it is an important component of dusty torus models. We found that several AGNs are bluer than models predict. We discuss several explanations for this and find that it is most plausibly stellar light contamination within the ISAAC L-band nuclear fluxes.
An Implicit Finite Volume Scheme to Solve the Time-dependent Radiation Transport Equation Based on Discrete Ordinates
Authors: Jiang 姜 Yan-Fei 燕飞
Published: April 2021

We describe a new algorithm to implicitly solve the time-dependent, frequency-integrated radiation transport (RT) equation, which is coupled to an explicit solver for equations of magnetohydrodynamics (MHD) using Athena++. The radiation field is represented by specific intensities along discrete rays, which are evolved using a conservative finite volume approach for both Cartesian and curvilinear coordinate systems. All terms for spatial transport of photons and interactions between gas and radiation are calculated implicitly together. An efficient Jacobi-like iteration scheme is used to solve the implicit equations. This removes any time-step constraint due to the speed of light in RT. We evolve the specific intensities in the lab frame to simplify the transport step. The lab frame specific intensities are transformed to the comoving frame via Lorentz transformation when the source term is calculated. Therefore, the scheme does not need any expansion in terms of v/c. The radiation energy and momentum source terms for the gas are calculated via direct quadrature in the angular space. The time step for the whole scheme is determined by the normal Courant–Friedrichs–Lewy condition in the MHD module. We provide a variety of test problems for this algorithm, including both optically thick and thin regimes, and for both gas and radiation pressure-dominated flows to demonstrate its accuracy and efficiency.
Liverwort flora of Ayan – a gained link between subarctic and hemiboreal floras in West Okhotiya (Pacific Russia)
Authors: Bakalin Vadim , Klimova Ksenia , Bakalin Daniil , Choi Seung Se
Published: April 2021

The liverwort flora of Ayan was first investigated one hundred and fifty years after the first exploration of vascular plants. A number of factors has determined the relatively high taxonomic diversity of liverworts in this hemiarctic flora of small-sized area: 118 species and one subspecies were revealed. These data are new not only for the studied area, but also for the huge land adjacent to the western coast of the Sea of Okhotsk. The liverwort flora possesses the domination of taxa common in the hemiarctic, although with a lot of taxa more common in boreal as well as arctic-alpine environments. The presence of Mega-Beringian and calciphilous taxa is the peculiar trait of the studied liverwort flora. Based on detrended correspondence analysis (DCA), Ayan liverwort flora shows relationships to the continental mainland floras situated both in North-East Asian hemiarctic and hemiboreal East Asia and is, therefore, the link between both. The flora of Ayan surroundings is one of the newly-filled ‘blank spots’ in the possible floral exchange way between Arctic Northeast Asia and mountainous floras of temperate East Asia.
Pharmacotherapy of patients with atrial fibrillation and restored sinus rhythm – is the medication with spironolactone beneficial in this case?
Authors: Kisheva Antoniya , Yotov Yoto , Grigorov Evgeni
Published: April 2021

Objective: Atrial fibrillation is progressive disease with important health consequences, in which fibrosis is a key player. The aim of our study is to assess the effect of mineralcorticoid blockade on top of standard treatment in patients with atrial fibrillation after sinus rhythm restoration on the recurrence of the arrhythmia, hospitalizations and on the changes in levels of Galectin-3 as a marker of fibrosis.

Methods: We prospectively studied 101 consecutive patients (56 females) at mean age 68.2 ± 7 with atrial fibrillation and sinus rhythm restoration, who were randomized on treatment with spironolactone on top of standard treatment or “usual care”. They were followed up for recurrences, hospitalization and death. The effect of spironolactone on safety was evaluated.

Results: Recurrences of AF were detected in 64% of non-spironolactone group vs 57% in spironolactone group (p = 0.44). Spironolactone reduced the hospitalizations for AF, but it was not significant (p = 0.14). A Cox regression model showed only protective effect of spironolactone on AF hospitalizations, HR = 0.48, 95%CI = 0.2–1.15, р = 0.098. The same survival model for all-cause hospitalizations reached significance, with reduction of the events in the spironolactone group, HR- 0.44, 95% CI 0.2–0.94, р = 0.035. There was no difference regarding the composite endpoint (recurrences, all cause hospitalizations and death). Treatment with spironolactone did not influence the Gal-3 levels. Treatment with spironolactone has not influenced significantly the levels of serum potassium and creatinine.

Conclusion: Treatment with spironolactone has protective effect regarding hospitalization for atrial fibrillation and significantly reduces all cause hospitalizations. It does not influence the biomarker of fibrosis Gal-3 after one-year treatment. The use of spironolactone in patients with AF is safe, but regular follow up is needed and recommended. Further studies are necessary, to clarify the potential of spironolactone to improve the AF prognosis.
Assessment the effects of insulin on adiponectin, nitric oxide, myeloperoxidase and lipid profile in type 1 diabetic patients
Authors: Mohammad Jehan A. , Fathi Zainab H. , Allwash Thikra Ali
Published: April 2021

Type 1 diabetes (T1DM) is well recognized risk factor cardiovascular disease (CVD). Insulin therapy is recommended for all patients with type 1 diabetes. Previous findings showed that diabetes impairs endothelial function and increased glucose level reduces nitric oxide (NO) output and increases myeloperoxidase (MPO) activity. However, adiponectin (APN) decreases serum glucose levels. The current study evaluated effects of insulin therapy on circulating levels of oxidative stress and CVD biomarkers like NO, APN, MPO, AIP and lipid profile in type 1 diabetic patients. Fifty patients with T1DM and 18 healthy people were enrolled in this study. The recruited people with T1DM were classified into two groups: 22 newly diagnosed (untreated) type 1 diabetic patients and 28 insulin treated patients. In all groups, circulating NO, APN, MPO, AIP and lipids levels were measured. Compared to control, untreated diabetes revealed a significant increase in the serum levels of APN, MPO, TG, VLDL, TC, LDL and AIP, with a marked reduction in NO and HDL levels. However, insulin therapy significantly lowered MPO, TC and LDL, with no significant changes in the other biochemical parameters. As expected, oxidative stress and CVD-associated markers were significantly increased in untreated diabetes. Insulin therapy exhibited a relatively positive effect on oxidative stress and CVD biomarkers. Accordingly, insulin plus antioxidant supplementation required to normalize these parameters.
Littérature et philosophie : intersection et frontières
Authors: Vidmar Jovanović Iris , Py Jean-Luc
Published: April 2021

Cet article s’inspire du manuscrit de l’ouvrage de Philip Kitcher, Deaths in Venice: The Cases of Gustav von Aschenbach 3 dans lequel il livre une lecture, d’inspiration philosophique, du roman de Thomas Mann. Mon point de départ est une des thèses soutenues par Kitcher : la philosophie se fait aussi au sein de certaines formes artistiques comme la littérature et la musique. En tant que cognitiviste littéraire, il livre des arguments solides en faveur de la valeur cognitive de la littérature. Dans cet article, mon objectif est double : premièrement, analyser la relation entre philosophie et littérature pour montrer que, malgré un certain chevauchement, on doit les maintenir séparées ; deuxièmement, explorer quelles ramifications en résultent pour le cognitivisme littéraire.
The relationship between the phageome and human health: are bacteriophages beneficial or harmful microbes?
Authors: Fernández L. , Duarte A.C. , Rodríguez A. , García P.
Published: April 2021

In the context of the global antibiotic resistance crisis, bacteriophages are increasingly becoming promising antimicrobial agents against multi-resistant bacteria. Indeed, a huge effort is being made to bring phage-derived products to the market, a process that will also require revising the current regulations in order to facilitate their approval. However, despite the evidence supporting the safety of phages for humans, the general public would still be reluctant to use ‘viruses’ for therapeutic purposes. In this scenario, we consider that it is important to discuss the role of these microorganisms in the equilibrium of the microbiota and how this relates to human health. To do that, this review starts by examining the role of phages as key players in bacterial communities (including those that naturally inhabit the human body), modulating the species composition and contributing to maintain a ‘healthy’ status quo. Additionally, in specific situations, e.g. an infectious disease, bacteriophages can be used as target-specific antimicrobials against pathogenic bacteria (phage therapy), while being harmless to the desirable microbiota. Apart from that, incipient research shows the potential application of these viruses to treat diseases caused by bacterial dysbiosis. This latter application would be comparable to the use of probiotics or prebiotics, since bacteriophages can indirectly improve the growth of beneficial bacteria in the gastrointestinal tract by removing undesirable competitors. On the other hand, possible adverse effects do not appear to be an impediment to promote phage therapy. Nonetheless, it is important to remember their potentially negative impact, mainly concerning their immunogenicity or their potential spread of virulence and antibiotic resistance genes, especially by temperate phages. Overall, we believe that phages should be largely considered beneficial microbes, although it is paramount not to overlook their potential risks.
Stable isotope ratio analysis for the characterisation of edible insects
Authors: Pianezze S. , Perini M. , Bontempo L. , Piasentier E. , Poma G. , Covaci A. , Camin F.
Published: April 2021

Entomophagy, or the act of eating insects, has been practiced since ancient times, but it started to gain more popularity, especially in Western countries, only recently. As sustainability is one of the current emerging themes, the inclusion of insects in our diet is a valid alternative that might help reduce the amount of water and land used for livestock and the associated emissions of greenhouse gasses. Moreover, insects are a source of protein, fibres, vitamins, minerals and fats. Edible insects are considered a novel food, for which no isotopic reference values are yet available. In the present work, samples of farmed edible insects (n=40) belonging to different orders (namely, Coleoptera, Hemiptera, Hymenoptera, Lepidoptera, Odonata and Orthoptera) and insect-based food items (n=4) for human consumption were analysed. The following isotopes, δ13C, δ15N, δ34S, δ18O and δ2H of the defatted samples, together with the δ13C of the fat, were investigated. The aim of the work was to provide the first reference isotopic ratios that can be used for future investigations in the food quality field. The variability of these parameters was dependent on the life stage and diet of insects, their geographical origin, and the addition of ingredients as seasoning.
Le jeu et son nom : qu’est-ce qu’un auteur de jeu vidéo ?
Authors: Aarseth Espen
Published: April 2021

On s’interroge ici sur la possibilité d’élaborer une notion « d’auteur » adéquate au champ du jeu vidéo. L’enquête commence par une réflexion sur quelques grands noms du domaine reconnus par une instance légitime du secteur. Il s’avère que ces créateurs sont peut-être moins des auteurs que des créateurs géniaux d’outils numériques, des architectes ou des raconteurs d’histoires – sans atteindre au statut d’auteur complet. Pour cela, il leur faudrait non seulement avoir réalisé plusieurs jeux marquants auxquels leurs noms seraient associés, mais avoir en outre ambitionné la transmission d’un certain message (politique). L’auteur complet serait alors celui qui réussirait à imposer sa vision singulière à une industrie surpuissante affamée de productions calibrées. Leur heure est peut-être encore à venir.Vingt ans plus tard, un regard rétrospectif permet de confirmer l’intuition. Le secteur a mûri, s’est énormément développé et a donc libéré de la place pour des créations en marge : jeux d’auteur, retrogaming, art game et jeux indépendants.
Théâtre immersif et jeu vidéo
Authors: Levet Olivia
Published: April 2021

Le jeu vidéo et les interfaces numériques, durant leur développement, se sont nourris du théâtre et des arts vivants, afin d’intégrer la prise en compte de l’utilisateur et de l’humain dans leur conception. Aujourd’hui l’apparition d’un « théâtre immersif » confirme ce rapprochement. À travers l’analyse sociocritique du processus créatif de deux œuvres théâtrales, Greenhive Green de Punchdrunk Enrichment et The Lost Generation de Madame Lupin, cet article analyse de manière croisée la résidence en théâtre et la mise en place de playtests et de versions anticipées dans le domaine du jeu vidéo. Possédant un vocabulaire, des procédés et des ambitions communs, le théâtre immersif et le jeu vidéo semblent constituer un miroir à une idéologie dominante instaurant une ère du participatif, où l’individu entrepreneur, autonome et indépendant est valorisé au détriment des autres, comme le suggère l’analyse d’Adam Alston du travail de la compagnie Punchdrunk. Pourtant, à l’image d’un théâtre participatif politique – le Théâtre de l’opprimé d’Augusto Boal –, certains artistes se réapproprient ces outils afin de construire une œuvre de manière collaborative, critique et à contre-courant, où la rencontre avec un public permet de coconstruire une expérience esthétique tournée vers l’émancipation.
Peut-on parler de partenariat apprenant en éducation à l’environnement ?
Authors: Bruxelle Yannick
Published: April 2021

Cette recherche-action s’appuie sur des formations de formateurs co-organisées par deux institutions relevant de l’Éducation nationale, un réseau associatif et un institut français. Elle explore les pratiques afin de mieux comprendre le fonctionnement et l’efficacité du système partenarial dans son ensemble. L’article présente l’ensemble de la démarche de recherche montrant que le partenariat est «  apprenant  » dans la mesure où il permet la création de connaissances et l’accès à des compétences nouvelles et inattendues, aussi bien au niveau des personnes que des organisations. Il explore des indicateurs de qualité du partenariat et montre la cohérence entre ces pratiques et celles de l’éducation relative à l’environnement (ERE) tout en cherchant à cerner les atouts et limites de cette notion nouvelle de partenariat apprenant.
Quel partenariat avec l’expert ? Réflexions sur l’aide, l’approche participative et l’éducation à l’environnement dans le Tiers Monde
Authors: Bidou Jean-Étienne
Published: April 2021

Dans les pays en voie de développement, les projets d’éducation à l’environnement s’inscrivent généralement dans le contexte de l’aide internationale. Ils émanent rarement d’une demande locale et suscitent difficilement l’adhésion de la population. Pour être véritables, les partenariats qui se nouent entre l’aide extérieure et les communautés locales doivent créer les conditions d’une réelle participation : laisser exprimer leurs besoins, leur assurer un contrôle de l’opération, leur permettre une évaluation régulière du projet. Ces nouvelles conditions transforment le rôle de l’expert, et d’une façon plus générale, celle de toute recherche.
La sensibilisation du personnel dans le cadre de la mise en place d’un système de management environnemental : une porte d’entrée pour l’éducation relative à l’environnement dans l’entreprise ?
Authors: Domasik-Bilocq Marie-Claire , Semal Nathalie , von Frenckell Marianne
Published: April 2021

L’accroissement des besoins en formation relative à l’environnement en entreprises, suite à l’essor des systèmes de management environnemental en Belgique, fait apparaître de nouveaux besoins de recherche en éducation relative à l’environnement (ErE). D’une démarche réflexive sur leur propre pratique, les auteures montrent qu’une convergence entre les attentes des entreprises et les objectifs de l’ErE est possible. Cette étude met en évidence l’efficience de la sensibilisation du personnel comme moyen pour faire évoluer les comportements d’adultes, tant dans le cadre professionnel que dans le contexte de la vie privée. Cette efficience est basée sur la construction collaborative de l’action de formation, le partage des responsabilités et la réciprocité des apprentissages. Les limites de l’intervention en ErE dans ce cadre sont liées aux spécificités de la culture organisationnelle et aux capacités d’évolution de cette culture.
Adventures on the Golden Road
Authors: Crawford Caroline M. , Andrews White Sharon
Published: April 2021

Two mid-career university professors with quite diverse areas of specialization and expertise come together to discuss their own professional journeys that they describe as the winding golden road. Embedding their own experiences and mentoring opportunities towards sharing information and hard-learned lessons with others offers a natural pay it forward progression. The two authors take a historical look over their careers that have already spanned almost 50 years together, offers the opportunity to reflect on opportunities and ruminating over lessons learned. Professional options and opportunities that directly impacted career choices will also be discussed. With a sometimes tongue-in-cheek recognition of “do as I say and not necessarily as I do” is how these two colleagues have attempted to guide and influence talented colleagues. An analysis of the professional landscape is a priority, considering the impact of a professional career upon one's work-life balance as well as sense of wellness.
Waqf Crowdfunding for Financing the MSMEs
Authors: Yunia Fauzia Ika , Musari Khairunnisa
Published: April 2021

Waqf financing through crowdfunding becomes an attractive instrument in Islamic social finance today. Crowdfunding offers a solution to the capital problem in developing waqf assets by using the concept of raising funds through social media and internet users. This chapter will describe how waqf crowdfunding also can be a tool for financing the micro small medium enterprises (MSMEs). In the digital era, the impact of waqf on people in need could be greater with crowdfunding, where waqif is not limited by geographical barriers. Waqf crowdfunding becomes a marketplace platform to increase financial inclusion through collaboration between Islamic social finance and technology. There are some platforms of waqf crowdfunding in the Association of Southeast Asian Nations (ASEAN) that will be described in this chapter (i.e., Indonesia, Malaysia, and Singapore).
Indonesian Higher Education Student Perception on Procurement Manager Skills and Competencies
Authors: Masudin Ilyas , Safitri Nika Tampi , Agata Revon Awalia Wahyu , Prawita Rizky Purnama Putri Hadi , Restuputri Dian Palupi
Published: April 2021

This chapter discusses the differences in the perceptions of industrial engineering students at Indonesian higher degree institution about the skills and competencies required for procurement managers. This study uses descriptive statistical analytical with the number of 100 respondents. There are 3 dimensions of skills and competencies investigated in this study such as the dimension of resources managerial skills and competencies, self-competencies and skills, and the company's internal and external managerial skills and competencies. The expected result of this chapter is to indicate tha the most important skill that required based on the student's perception for procurement managers.The dimensions such as leadership, analytical skill, internal and external managerial skills, and decision-making skill are tested to figure out the most prioritized skills of being procurement managers.
Towards Divine Values' Strategic Application
Authors: Huda Miftachul , Safori Amjad Omar , Rofiq Abdullah , Hashim Azmil , Che Noh Mohd Aderi , Ibrahim Mohd Hairy , Mohamed Ahmad Kilani , Rosman Arieff Salleh
Published: April 2021

The technological progression is widely being transformed into many sectors, such as education, business, and social interaction and communication. Such expansion has its unique basis since it provides the service enhancement through real-time-based interrelation towards the certain object in the smart platform. However, the problematic challenges have been emerged for instance cyber-bullying, moral challenges in online, cyber-crime, which all required the particular attention on the spiritual enhancement as the foundation in the personality development. This chapter attempts to propose the theoretical framework in responding the challenging issues in online basis. The critical assessment is conducted through books, conferences, and articles related to the divine-strategic principles to give insights into the management of change. The outcome reveals that the particular element of mashlahah (appropriate goodness) played a significant role in underlying the critical elements on driving pathway of management of change.
Continuing metamorphosis of evidence-based medicine; the past, present and the future
Authors: Gunaratne Asoka , Jayarajah Umesh , Abeygunasekera Anuruddha M.
Published: April 2021

No abstract available
Acute septic arthritis of the hip joint with abscess formation; a rare presentation of melioidosis
Authors: De Silva C. M. , Fonseka C. L. , Singhapura S. D. A. L. , Hewawithana J. S. , Piyasiri D. L. B. , Lekamwasam S.
Published: April 2021

No abstract available
Astragalus Ⅳ ameliorates the dry eye injury in rabbit model via MUC1-ErbB1 pathway
Authors: Chu Li , Ma Suhong , Chen Zhiwei , Cao Wenfu
Published: April 2021

The therapeutic effects and potential mechanisms of astragaloside IV on a rabbits dry eye model induced by benzalkonium chloride (BAC) was examined. In our study, a BAC-induced dry eye rabbit model was treated with eye drops containing astragaloside IV (5, 10 μM) or solvent four times a day. The clinical evaluations, such as tear break-up time (BUT) and Schirmer tear test (STT), were performed on days 0, 7, 14, 21, and 28. On day 28, the cornea and bulbar conjunctiva tissues (left eye and right eye) were collected with histology, and immunofluorescent staining conducted. The levels of MUC1 and ErbB1in the corneas were determined by real-time quantitative PCR (qRT-PCR) and the proteins levels of MUC1 and ErbB1 were detected by Western blot. It was demonstrated that both astragaloside IV (5, 10 μM) treatments resulted in an increased STT and BUT on days 7, 14, 21 and 28. Additionally, the astragaloside IV (5, 10 μM)-treated group showed increasing PAS-positive goblet cells than model group (0 μM). Moreover, the MUC1 in model group (0 μM) was decreased, while the expression of MUC1 in astragaloside IV (5, 10 μM) group was increased. Furthermore, astragaloside IV had a protective effect on BAC-induced rabbits’ dry eye and demonstrated clinical improvements, which indicated that astragaloside IV served as a potential protective agent in the clinical treatment of dry eye.
Indirect comparison between ferric carboxymaltose and oral iron replacement in heart failure with reduced ejection fraction: a network meta-analysis
Authors: Sciatti Edoardo , Nesti Ugo , Di Lenarda Andrea
Published: April 2021

Treatment of iron deficiency (ID) in patients with heart failure (HF) has improved symptoms, quality of life, exercise capacity and has reduced hospitalizations in randomized controlled trials (RCTs) and meta-analyses. Intravenous ferric carboxymaltose (FCM) provided convincing results in this field, while oral iron supplementation failed. However, FCM and oral iron were compared to placebo, and a comparison between the two strategies is still lacking. We aimed to fill this gap of knowledge with an indirect comparison between them by means of a network meta-analysis of RCTs. Five studies measuring exercise capacity (i.e. 6-minute walking test) and quality of life (i.e. Kansas City Cardiomyopathy Questionnaire) were eligible to be included in our review. Given the limitations of a network meta-analysis, our findings support the better efficacy of FCM than oral iron as regards exercise capacity, with a trend towards an improvement in quality of life, suggesting that FCM seems to be strategy of choice to correct ID in HF patients.
The initial experience of COVID-19 vaccination from a tertiary care centre of India
Authors: Srivastava RK , Ish Pranav , COVID-19 Vaccination group *Safdarjung
Published: April 2021

To the Editor
Drugs Controller General of India (DCGI) has approved the Bharat biotech vaccine against COVID-19, which is a locally manufactured inactivated vaccine named ''COVAXIN'' in collaboration with the Indian council of medical research (ICMR) on 3rd  January 2021 for emergency use along with the "Covishield" Oxford-AstraZeneca vaccine manufactured locally by the Serum Institute of India...
*The Safdarjung COVID-19 Vaccination group:
KR Meena (Professor, Paediatrics), U Venkatesh (Assistant Professor, Community Medicine), Pushpa Kumari (Associate Professor, Medicine), Sonal Burman (Specialist, Medicine), Neeraj Kumar Gupta (Professor and Head, Pulmonary Medicine), Nitesh Gupta (Assistant Professor, Pulmonary Medicine), Rohit Kumar (Assistant Professor, Pulmonary Medicine), Swetabh Purohit (Senior resident, Pulmonary Medicine), Arjun Ramaswamy (Senior resident, Pulmonary Medicine)
Table of Contents Vol 12, No 1 (2020)
Authors: Office Editorial
Published: April 2021

Not applicable
Clinical and Genetic Characteristics of Coronary Artery Disease in Chinese Young Adults: Rationale and Design of the Prospective G enetic characteristics of co R onary A rtery disease in Chi N ese young a D ults (GRAND) Study
Authors: Shalaimaiti Shali , Dai Yu-Xiang , Wu Hong-Yi , Qian Ju-Ying , Zheng Yan , Yao Kang , Ge Jun-Bo
Published: April 2021

Abstract

Background:

Emerging evidence indicates that the worldwide incidence of early-onset coronary artery disease (EOCAD) is increasing. The genetic background has been assumed to harbor pathogenic risk, although the existing findings are mainly restricted to Caucasians. Little is known regarding the clinical profiles of patients with EOCAD and the extent to which genetic factors are related to disease susceptibility and outcomes in Asian people, especially ethnic Chinese.

Methods and Results:

The Genetic characteristics of coRonary Artery disease (CAD) in ChiNese young aDults (GRAND) study is a multicenter, hospital-based observational clinical study, combined of case-control design and longitudinal prospective cohort. Six thousand nationally representative patients who underwent coronary angiography at 38 centers have been enrolled since May 2017. Clinical data of patients with EOCAD (aged ≤45 years) are collected at the baseline to delineate conventional risk factors, clinical profiles, and therapeutic options of EOCAD and compared with data for patients with late-onset CAD (aged ≥65 years) and age-matched controls without CAD. The patients are followed for 3 years to trace major adverse cardiovascular (CV) events: cardiac death, nonfatal myocardial infarction, and ischemia-driven revascularization. Functional variants contributing to EOCAD risk are identified by high-depth whole-exome sequencing. The genetic profiles are further linked to disease severity and prognosis. A multi-dimensional risk score is established to predict prevalent EOCAD and incident CV events among young Chinese adults.

Conclusions:

The GRAND study will generate a thorough understanding of the clinical characteristics and genetic basis of EOCAD and may pave the way for genetic screening, early prevention, and future drug discovery for CAD in young Chinese generations.
Increased Risk of Diabetes after Definitive Radiotherapy in Patients with Indolent Gastroduodenal Lymphoma
Authors: Baek Jong Yun , Lim Do Hoon , Oh Dongryul , Nam Heerim , Kim Jae J , Lee Jun Haeng , Min Byung-Hoon , Lee Hyuk
Published: April 2021

Purpose This study aimed to evaluate the effect of radiotherapy (RT) on the risk of diabetes by assessing hemoglobin A1c (HbA1c) levels in patients with gastroduodenal indolent lymphoma.Materials and Methods This retrospective study included patients with stage I extranodal marginal zone lymphoma of the mucosa-associated lymphoid tissue or follicular lymphoma of the gastroduodenal region who were treated with Helicobacter pylori eradication and/or RT between 2000 and 2019 in our institution. Of total 79 patients with HbA1c test, 17 patients received RT (RT group), while 62 patients did not receive RT (control group). A diabetes-associated event (DAE) was defined as a ≥ 0.5% increase in HbA1c levels from baseline, and diabetes event (DE) were defined as HbA1c level of ≥ 6.5%.Results During the median follow-up of 49 months, no local failure occurred after RT and no patients died of lymphoma. The RT group had significantly higher risk for DAEs on univariable analysis (hazard ratio [HR], 4.18; 95% confidence interval [CI], 1.64 to 10.66; p < 0.01) and multivariable analysis (HR, 3.68; 95% CI, 1.42 to 9.56; p=0.01). Further, the DE risk was significantly higher in the RT group than in the control group (HR, 4.32; 95% CI, 1.08 to 17.30; p=0.04) and in patients with increased baseline HbA1c levels (HR, 35.83; 95% CI, 2.80 to 459.19; p=0.01). On multivariable analysis, RT significantly increased the risk of DEs (HR, 4.55; 95% CI, 1.08 to 19.19; p=0.04), even after adjusting baseline HbA1c level (HR, 40.97; 95% CI, 3.06 to 548.01; p=0.01).Conclusion Patients who received RT for gastroduodenal indolent lymphoma had an increased risk of diabetes compared to those who did not.
„Sztuka parkowania” – wykorzystanie parkingów Kampusu 600-lecia Odnowienia Uniwersytetu Jagiellońskiego w kontekście polityki zrównoważonej mobilności
Authors: Bubak Grzegorz , Jabłoński Adam , Biesaga Jakub
Published: April 2021

“The art of parking” – using the car parks of the Campus of the 600th Anniversary of the Jagiellonian University Revival in the context of sustainable mobility policy

Sustainable mobility is one of the most current challenges of contemporary spatial planning, which focuses also on parking policy. Keeping balance between the demand and supply of parking space as well as using those in public space is under debate in many cities. The goal of the research was to evaluate the efficiency of parking policy on the 3rd Jagiellonian University Campus in Krakow. For five days, at three fixed times, the occupancy level of parking spaces was measured, and the obtained results were analyzed, which helped Authors to propose a number of spatial and organizational solutions. For a better understanding of the source of the problems, photographical documentation was made and unstructured interviewing was conducted. The Authors came to a conclusion that the parking space resources are used ineffectively despite the fact that the number of parking spots exceeds the demand of users. The obtain ed results were discussed in relation to the experiences of other universities in the country and in the world. The main idea of the article is to look at the university as an institution with special social responsibility in the implementation of solutions ensuring sustainable mobility.

Zarys treści: Zrównoważona mobilność jest aktualnym wyzwaniem współczesnego gospodarowania przestrzenią, którego jednym z elementów jest polityka parkingowa. W wielu miastach prowadzone są debaty na temat zachowania równowagi między popytem na miejsca postojowe a ich podażą oraz udziałem tych miejsc w przestrzeni publicznej. Celem badania była ocena efektywności polityki parkingowej na obszarze III Kampusu Uniwersytetu Jagiellońskiego w Krakowie. Przez pięć dni, o trzech stałych porach, dokonano pomiaru zapełnienia miejsc parkingowych, a otrzymane wyniki poddano analizie, co umożliwiło zaproponowanie szeregu rozwiązań przestrzennych i organizacyjnych. Ponadto, przeprowadzono w terenie dokumentację fotograficzną i kilka nieustrukturyzowanych wywiadów, dzięki czemu możliwe było lepsze zrozumienie przyczyn problemów. Najważniejszym wnioskiem badań jest nieefektywne wykorzystanie zaplecza parkingowego, pomimo posiadania zasobów znacznie przekraczających zapotrzebowanie użytkowników. Otrzymane rezultaty omawiane są w odniesieniu do doświadczeń innych szkół wyższych w kraju i na świecie. Myślą przewodnią artykułu jest spojrzenie na uczelnię jako instytucję o szczególnej odpowiedzialności społecznej w zakresie wprowadzania rozwiązań zapewniających zrównoważoną mobilność.
Laboratorium GeoDesignu – koncepcja przestrzeni do pracy kreatywnej na Kampusie 600-lecia Odnowienia Uniwersytetu Jagiellońskiego
Authors: Luc Małgorzata , Pietrzak Małgorzata , Rotter-Jarzębińska Katarzyna
Published: April 2021

GeoDesign Laboratory – a concept of a space for creative work on the Campus of the 600th Anniversary of the Jagiellonian University Revival

GeoDesign is a set of techniques and technologies allowing to combine geographic analysis with the design process. It has an interdisciplinary character and is used to create projects of both natural and socio-cultural nature, on the basis of which it is possible to make the most rational decisions. As part of creating a sustainable Campus of the 600th Anniversary of the Jagiellonian University Revival, and at the same time in response to the prevailing trends in planning space for education and communicating the values of higher education, a concept of creating a geodesign laboratory will be presented. It is designed for the community of the Institute of Geography and Spatial Management of the Jagiellonian University in Kraków, and, more broadly, for the Faculty of Geography and Geology of our University. Scientific research confirms the effectiveness of space organized so as to stimulate creativity, encourage teamwork, and give an opportunity to apply methods in the field of geodesign, design thinking and learning by doing. Creating space for design activities is a noticeable trend at modern universities. The publication presents several examples of spaces with a similar function from Poland and abroad. The last part of the article presents a proposal of the appearance and functioning of the designed space for creative work.

Zarys treści: GeoDesign to zestaw technik i technologii, które pozwalają na połączenie analiz geograficznych z procesem projektowania. Ma on charakter interdyscyplinarny i służy do tworzenia projektów zarówno o charakterze przyrodniczym, jak i społeczno-kulturowym, na bazie których możliwe jest podejmowanie jak najbardziej racjonalnych decyzji. W ramach tworzenia zrównoważonego kampusu, a jednocześnie w odpowiedzi na panujące trendy w planowaniu przestrzeni do edukacji i komunikowania wartości szkolnictwa wyższego, zostanie zaprezentowana koncepcja utworzenia laboratorium geodesignu. Jest ono projektowane na potrzeby społeczności Instytutu Geografii i Gospodarki Przestrzennej Uniwersytetu Jagiellońskiego i szerzej – Wydziału Geografii i Geologii naszej Uczelni. Badania naukowe potwierdzają efektywność przestrzeni zorganizowanej tak, aby pobudzała kreatywność, zachęcała do pracy zespołowej, dawała możliwość zastosowania metod z zakresu geodesign, design thinking i learning by doing. Tworzenie przestrzeni do działań projektowych jest zauważalnym trendem na współczesnych uniwersytetach. W publikacji zaprezentowano kilka przykładów przestrzeni o podobnej funkcji z Polski i z zagranicy. W ostatniej części artykułu przedstawiono propozycję wyglądu i sposobu funkcjonowania projektowanej przestrzeni do pracy kreatywnej.
Características argumentativas de la interpretación de tablas de frecuencia en estudiantes chilenos de segundo año medioe Segundo Año Medio
Authors: González Venegas Carmen Paz , Muñoz Guajardo Rosa , Muñoz Pardo Joel
Published: April 2021

La enseñanza de la estadística y probabilidad inicia en los primeros años de educación básica pues ambas ramas son necesarias para comprender e implementar el ciclo de investigación estadística desde la recolección de datos, su procesamiento, análisis y elaboración de conclusiones a partir de estos. Esta investigación cualitativa y descriptiva se centró en recoger información sobre las características argumentativas de la interpretación de tablas de frecuencia para datos agrupados, en estudiantes de segundo medio (15-16 años), lo cual es relevante pues la interpretación de este tipo de tablas conlleva a errores y problemas dentro del ciclo investigativo estadístico. Desde distintos análisis de interpretaciones de elementos estadísticos para los gráficos y adaptados a las tablas de frecuencia atingentes a esta investigación, se propusieron tres categorías para estas interpretaciones: racional, intuitivo y literal, de las cuales predominó el tipo racional consistente en utilizar conceptos y explicaciones matemáticas pertinentes, con la seguridad de que son los mecanismos adecuados para resolver problemas, generando argumentos con fundamentos matemáticos.
Pengaruh Pengetahuan Non Formal, Pendapatan, dan Pengalaman terhadap Minat Pengembangan Bisnis Ternak
Authors: Khairi Ardhi
Published: April 2021

Jumlah sapi potong di Indonesia merupakan isu yang tidak pernah bisa diselesaikan hingga saat ini. Bagi pemerintah, mendorong peternak yang sudah ada untuk mengembangkan bisnis ternak sapi potong menjadi cara yang paling mungkin untuk diusahakan. Fokus penelitian ini adalah mencari pengaruh pengetahuan nonformal, pendapatan, dan pengalaman terhadap minat pengembangan bisnis ternak sapi potong dari peternak yang ada di Kecamatan Ngombol. Data yang telah dikumpulkan sebanyak 50 responden dari total 451 peternak dengan menggunakan kuesioner. Dengan menggunakan regresi liner berganda, penelitian ini mengungkapkan sejauh mana pengaruh pengetahuan nonformal, pendapatan, dan pengalaman terhadap minat pengembangan bisnis ternak sapi potong.
Kadar Kolesterol, Asam Urat dan Glukosa Darah Ayam Petelur yang Diberi Jus Daun Sirih (Piper betle Linn) pada Level yang Berbeda
Authors: Badaruddin Rusli , Aka Rahim , Ollong Abdul Rahman , Tiya Ning Ayu Dwi
Published: April 2021

ABSTRACT         

This study aims to assess cholesterol, uric acid and blood glucose levels in laying hens which are fed with the addition of betel leaf juice (Piper Bettle Linn). There were 16 chickens used in layer phase hens. The cage used is an individual cage equipped with a place for feeding and drinking water. The treatments in this study consisted of: (P0) commercial feed + 0 ml of betel leaf juice, (P1) commercial feed + 5 ml of betel leaf juice, (P2) commercial feed + 10 ml of betel leaf juice, and (P3) commercial feed + 15 ml of betel leaf juice. The variables observed were cholesterol, uric acid and blood glucose levels. The data obtained from the research results were analyzed using variance and continued with Duncan's multiple range test. The results showed that the administration of betel leaf juice had no significant effect (p <0.05) on cholesterol, uric acid and blood glucose levels in layer phase hens. Based on the results of the study, it can be concluded that the administration of betel leaf juice does not affect the amount of cholesterol, uric acid, and glucose levels in layer phase hens, but these conditions are still in normal physiological conditions.

Keywords: uric acid, layer hens, glucose, cholesterol

ABSTRAK

Penelitian ini bertujuan untuk mengkaji tentang kadar kolesterol, asam urat dan glukosa darah ayam petelur yang diberi penambahan jus daun sirih (Piper betle Linn) pada level yang berbeda. Ayam yang digunakan sebanyak 16 ekor induk ayam petelur betina fase layer. Kandang yang digunakan yaitu kandang individu yang dilengkapi dengan tempat pakan dan air minum. Perlakuan pada penelitian ini terdiri atas: (P0) pakan basal + 0 ml jus daun sirih,  (P1) pakan basal + 5 ml jus daun sirih,  (P2) pakan basal + 10 ml jus daun sirih, dan (P3) pakan basal + 15 ml jus daun sirih. Variabel yang diamati adalah kadar kolesterol, asam urat, dan glukosa darah. Data yang diperoleh dari hasil penelitian dianalisis menggunakan sidik ragam dan dilanjutkan dengan uji jarak berganda Duncan. Hasil penelitian menunjukkan bahwa pemberian jus daun sirih tidak memberikan pengaruh yang nyata (p<0.05) terhdadap kadar kolesterol, asam urat dan glukosa darah ayam petelur fase layer. Berdasarkan hasil penelitian dapat disimpulkan bahwa pemberian jus daun sirih tidak mempengaruhi jumlah kadar kolestero, asam urat, dan glukosa ayam petelur fase layer, namun kondisi tersebut masih dalam kondisi fisiologis normal.

Kata Kunci : asam urat, ayam petelur, glukosa, kolesterol
National Research Conference 2020 - Special Issue
Authors: Secretary Organising
Published: April 2021

.