bluuebunny/crossref_metadata_2025 huggingface dataset:
Interação entre fatores sintáticos e fonológicos nos usos de vírgula em esquema duplo em textos do EFII
Authors: Paiva Nayra Cristina
Published: August 2023

O objetivo deste artigo é descrever e analisar os usos convencionais e não convencionais da vírgula em esquema duplo caracterizados por haver o emprego da vírgula tanto na fronteira direita quanto na fronteira esquerda da estrutura sintática mobilizada. A partir disso, identificar tendências e regularidades relacionadas a esses usos de vírgula e, também, caracterizar a quais fronteiras sintáticas e prosódicas do enunciado a vírgula em esquema duplo está relacionada. Para a realização deste trabalho, selecionamos uma amostra total de 205 excertos retirados do Banco de Dados de Escrita do Ensino Fundamental II. Os aspectos teóricos relacionam-se à multidimensionalidade da pontuação (CHACON, 1998) e ao modelo relation-based da Fonologia Prosódica (NESPOR; VOGEL, 1986).
Funcionalismo e mudança linguística em perspectiva construcional: a formação de marcadores discursivos em português
Authors: Oliveira Mariangela Rios de
Published: August 2023

Fundamentados na Linguística Funcional Centrada no Uso, nos termos de Rosário e Oliveira (2016), Furtado da Cunha, Bispo e Silva (2013) e Martelotta (2011), investigamos neste artigo as mudanças pré e pós-construcionais envolvidas na convencionalização de marcadores discursivos do português, mais especificamente os formados por subparte verbal e subparte pronominal locativa, codificados como [VLoc]MD. Tais mudanças são abordadas na perspectiva de cline contextual (DIEWALD; SMIRNOVA, 2012), que conduz à inserção dos referidos constituintes no paradigma dos MD, tomado este como uma hiperconstrução, nos termos de Diewald (2020). Em abordagem histórica, com base nos resultados obtidos por Teixeira (2015), Rosa (2019) e Sambrana (2021), demonstramos que a construcionalização [VLoc]MD é detectada inicialmente na língua no século XVI, mas sua consolidação como esquema formador de MD se generaliza a partir do século XIX, via analogização (BYBEE, 2010) e pressões contextuais, envolvendo metaforização, metonimização e expansão de intersubjetividade (TANTUCCI, 2018).
Deu tudo certo: uma análise diacrônica das microconstruções do subesquema [dar AA] no português brasileiro
Authors: Cumán Raissa Romeiro , Marques Priscilla Mouta
Published: August 2023

Este trabalho tem como principal objetivo realizar uma análise diacrônica das microconstruções do subesquema [dar AA], a saber: [dar certo], [dar errado], [dar ruim] e [dar bom], que se encontram construcionalizadas no português brasileiro atual, buscando identificar, através da análise de dados em corpus histórico, contextos que possam ter licenciado o surgimento destas construções. Fundamentamo-nos no aporte teórico metodológico da Linguística Funcional Centrada no Uso e no entendimento de que a língua é formada por uma rede de construções, sendo estas pareamentos de forma/sentido. Também visamos depreender os possíveis links entre essas tais microconstruções e a rede dos adjetivos adverbiais e dos verbos leves. Durante o desenvolvimento desta pesquisa, analisamos dados do século XIII ao século XXI que nos permitiram identificar construções como [dar por certo] e [dar como certo] que podem ter proporcionado o surgimento dessas construções. Acreditamos que esse trabalho seja de grande contribuição para o entendimento dessas microconstruções tão produtivas no português brasileiro atual, além de oferecer contribuições para o mapeamento da rede dos adjetivos adverbiais e a rede dos verbos leves.
A Qualitative Study on the Competency Model of Anti-Abuse Police Officers to improve professionalism in Response to Abuse Cases
Authors:   Korean Association of Public Safety and Criminal Justice, Kim Yun Hee , Shin Jae Woo , Cho Young Il
Published: August 2023

This study was conducted to develop a competency model for anti-abuse police officers to understand how the professionalism required for anti-abuse police officers is composed, and to make specific standards for education curriculum and selection process for anti-abuse police officer As a result of conducting interviews with anit-abuse police officers using BEI techniques, Lucia & Lepsinger (1999)'s three-step competencies analysis method, the anti-abuse police officer's competencies were derived into a total of five competencies: 'knowledge of victim psychology', 'knowledge of supporting victim system', 'legal knowledge', 'communication skills', and 'resilience'.
Factors Influencing Discrimination Experiences Towards Single-Parents
Authors:   Korean Association of Public Safety and Criminal Justice, Lee Ena , Lee Chang Bae
Published: August 2023

Single-Parent families in South Korea have been exposed to discrimination due to social prejudice and conservative views. Considering the rapid changes on family structure and the growing number of one-parent families, risk factors and protective factors on the experience of discrimination among single-parent families are needed to be identified. To identify the impact factors on the experience of discrimination among single-parent families, this study used data from 1,646 single-parent family household owners who raise underage children alone which had been conducted in 2021. Results suggest that gender, age, education, and depression had significant influences on the experience of discrimination. Our results also suggest that the comprehensive approach including psychological support is needed to prevent victimization among one-parent families. Policy suggestions and contents that need additional analysis were discussed.
Analysis of the relationship between cyber problem gambling level and entry motivation factors of juvenile delinquents: Focusing on group comparison according to the level of parental intervention
Authors:   Korean Association of Public Safety and Criminal Justice, Lee Jooyoung , Boo Minseo , Cho Younoh
Published: August 2023

This study aims at examining the association between gambling motivation factors and cyber problem gambling level toward juvenile delinquents. With the recent development of IT devices, teenagers engage in cyber gambling through various motives such as advertising, friends, and monetary purposes. Accordingly, hierarchical regression analysis was used for juvenile delinquents under probation to analyze entry motivation factors that affect the level of cyber problem gambling. As a result of the analysis, the level of cyber problem gambling increased as juvenile delinquents had a stronger motivation to enter for financial purposes. In addition, through the setting of control variables, it was derived that the more parents tried to intervene strongly in the gambling behavior of juvenile delinquents, the higher the level of cyber problem gambling. Based on this, the motivation for entry affecting the level of cyber problem gambling was analyzed by dividing the group with high and low levels of intervention in parents' child gambling behavior. As a result, the higher the level of parental gambling intervention, the stronger the “friend experience” factor, and the stronger the “monetary purpose” factor in the group with low parental intervention, the higher the level of problem gambling. Besides, cyber problem gambling of juvenile delinquents requires an appropriate resolution of financial problems. It was also confirmed that support and response policies need to be classified by the level of gambling intervention according to the difference in parenting attitudes of parents. Further policy implications will be discussed.
A Study on the Revitalization of the Family Entrustment System for the Protection of Children in Crisis
Authors:   Korean Association of Public Safety and Criminal Justice, Kim Bong-Soo , Kim Do-Woo , Lee Eun-Joo
Published: August 2023

The home consignment system provides protection for children exposed to crisis for a certain period of time, and is a necessary system for children subject to crisis protection to live in foster homes for a certain period of time. The Ministry of Health and Welfare said that from June 22, 2022, children subject to protection can be extended to 25 years old (to 24 years old) at their will, allowing them to enter society after fully preparing for self-reliance. Until now, children living in child care facilities had difficulty living alone at an early age, regardless of the degree of self-reliance preparation, except in some exceptional cases (schools below university, vocational education and training), and at the age of 18. With this revision, if the self-reliance ability is insufficient during the extension of the protection period, it is possible to determine whether to terminate the protection measures by comprehensively determining one's intention and level of self-reliance preparation. However, consignment families still lack childcare support funds, supply and demand costs far from reality, and supply and demand management systems. It is not easily accessible to general families, such as strict management of related agencies, notification of the return of supervisory agencies to the original course, qualification of foster families, screening, and management issues. It has been almost 20 years since the home consignment system was established, but it is still a big homework for us. The United States goes through complex procedures and screening to become a foster family, but because there is no social consensus on the importance of family consignment, it provides various social services to foster families such as housekeeper dispatch services, day care, and psychological counseling. The number of protected children is increasing rapidly due to repeated child abuse, and the difficulties of children already living in facilities have long been discussed. It is urgent to protect children in crisis by revitalizing the foster family system suitable for our reality.
Analysis of Terrorism Big Data Using Machine Learning
Authors:   Korean Association of Public Safety and Criminal Justice, Hong Seung Pyo
Published: August 2023

The purpose of this study is to analyze terrorism-related structured and unstructured big data using machine learning techniques for big data analysis to confirm the predictability of terrorism and derive implications. To this end, big data on terrorism was obtained from research institutes specializing in terrorism, articles and documents posted on various portals and SNS were collected, put into machine learning, and analyzed and learned, and the results were confirmed. The analysis results are as follows. First, as a result of conducting K-Means Clustering, a representative unsupervised learning among machine learning techniques, eight regional clusters of terrorism occurred around the world in 2021 (near Afghanistan, Democratic Republic of the Congo, India, Iraq, Myanmar, Nigeria, Pakistan, and Somalia). Next, as a result of clustering by type of terrorism, assassination using weapons excluding explosives, kidnapping or kidnapping targeting key facilities were identified. In addition, as a result of clustering around the means used in terrorism, it was confirmed that there were many explosives ahead, but there were differences according to the cluster. Finally, clusters of military, police, government personnel, civilians, and private property were identified as a result of clustering centered on targets of terrorism. Second, as a result of sentiment analysis by setting unstructured texts on terrorism events as research subjects, it was confirmed that there were differences in views on terrorism between terrorism researchers and the general public. Based on these research results, policy suggestions were made on ways to prevent terrorism.
Illusory ownership of one's younger face facilitates access to childhood episodic autobiographical memories
Authors: Gupta Utkarsh , Bright Peter , Clarke Alex , Zafar Waheeb , Recarte-Perez Pilar , Aspell Jane E.
Published: August 2023

Autobiographical memories are memories of previous experiences of one’s self, therefore it seems likely that autobiographical memories and self-representations interact in the brain. To test this in relation to the bodily self, we investigated whether the retrieval of childhood autobiographical memories would be facilitated by an illusion of ownership for a ‘child version’ of the participant’s own face. 50 neurologically healthy adults were tested in an online enfacement illusion study. Feelings of ownership and agency for the face were greater during conditions with visuo-motor synchrony than conditions with asynchrony. Critically, participants who viewed their child-like face recollected more childhood episodic memory details than those who viewed their adult face. No effects on autobiographical semantic memory recall were found. This finding indicates that there is an interaction between the bodily self and autobiographical memory. Our experimental paradigm could in future be adapted for its potential clinical application in memory disorders.
Diabetes Data Classification using Deep Learning Approach and Feature Selection based on Genetic
Authors: Abdollahi Jafar , NouriMoghaddam Babak , MIRZAEI ABBAS
Published: August 2023

The area of deep learning research (DL) has seen significant growth in recent years and has shown incredible promise for AI in medical applications. In this approach, we have proposed a deep neural network framework for the categorization of feature-based diabetes data. The dataset is classified using the SoftMax layer after features are collected from it using the wrapper approach. Additionally, the network is adjusted through supervised grid research with the training dataset. However, due to the risk of misdiagnosis in a medical context, we evaluated our model using measures such as precision, recall, specificity, and F1 score and obtained superior results. The proposed architecture has been tested using Diabetes 130-US hospital data, which consists of 100,000 patient files with an average of 55 attributes. As well, five machine learning algorithms—Nave Bayes, Random Forests, Decision Trees, Support vector machines, and Ensemble learning—are used to compare results from experiments. The classification accuracy of the ML algorithm was 86%. This research suggests a Deep Learning system based on feature selection for classifying diabetes data. This method has been tested on UCI machine learning data and has outperformed several other classification techniques, reaching 85.61% accuracy in this study.
Transcutaneous vagus nerve stimulation (tVNS) to acutely reduce emotional vulnerability and improve emotional regulation in borderline personality disorder (tVNS-BPD): study protocol for a randomized, single-blind, sham-controlled trial
Authors: Guerriero Giuseppe , Liljedahl Sophie , Carlsen Hanne , Muñoz Marta Lopez , Daros Alexander R. , Ruocco Anthony C. , Steingrimsson Steinn
Published: August 2023

Background: Borderline personality disorder (BPD) is considered a disorder of emotion regulation resulting from the expression of a biologically determined emotional vulnerability (that is, heightened sensitivity to emotion, increased emotional intensity/reactivity and a slow return to emotional baseline) combined with exposure to invalidating environments. Vagal tone has been associated with activity in cortical regions involved in emotion regulation and a lower resting state of vagal tone has been observed in BPD patients relative to healthy controls. Non-invasive transcutaneous vagus nerve stimulation (tVNS) has shown to reduce temper outbursts in adults with Prader-Willi Syndrome, to enhance recognition of emotions in healthy students and to improve depressive and anxiety symptoms. Furthermore, a single session of tVNS has been shown to acutely alter the recognition of facial expressions of negative valence in adolescents with MDD and increase emotion recognition in controls. However, the effect of tVNS on emotional vulnerability and regulation in individuals diagnosed with BPD has not been investigated. Our aims are to determine if tVNS is effective in acutely reducing emotional vulnerability and improve emotional regulation in BPD patients.
Methods: 42 patients will be randomized to a single session of tVNS or sham-tVNS while going through an affect induction procedure. It will consist of the presentation of one neutral and three negative affect-evoking 4-minutes-long videos in sequence, each of which is followed by a 4-minutes post-induction period during which participants will rate the quality and intensity of their current self-reported emotions (post-induction ratings) and the perceived effectiveness in managing their emotions during the video presentation. The rating of the current self-reported emotions will be repeated after every post-induction period (recovery ratings). Mixed models with individuals as random effect will be used to investigate the ratings at each stage of the study, taking into account the repeated measures of same individuals at baseline, pre-induction, post-induction and recovery).
Discussion: The study has potential to yield new insights into the role of vagal tone in emotion dysregulation in BPD and offer preliminary data on the effectiveness of tVNS as a possible non-invasive brain stimulation to treat a core symptom of BPD
Trial registration: ClinicalTrials.gov NCT05892900. Retrospectively registered on Jun 07, 2023. https://clinicaltrials.gov/show/NCT05892900.
Floral trait similarity and pollinator sharing between native and alien plants mediate heterospecific pollen transfer with consequences for pollination success
Authors: Parra-Tabla Victor , Albor Cristopher , Arceo-Gómez Gerardo
Published: August 2023

Heterospecific pollen transfer (HPT) is ubiquitous in co-flowering communities with strong implications for pollination success. Heterospecific pollen transfer may be especially relevant in invaded plant communities. The mechanisms mediating HPT in invaded communities however remain poorly understood even though it could help better understand the outcome of plant invasions. In this study, we use structural equation modeling to evaluate the role of floral trait similarity and pollinator sharing in HPT and pollination success of native plants in invaded coastal communities. Our results show that increased pollinator sharing between native and alien plants reduces total pollen loads on floral stigmas. In turn, an increase in total pollen load reduced proportion of heterospecific pollen (HP) but increased heterospecific pollen richness and the proportion of alien pollen (HPR and AHP respectively). The model showed that pollination success (i.e., proportion of pollen tubes) decreased with an increase in AHP but increased with increasing total HP. Unexpectedly, our results showed that floral trait similarity did not explain the degree of pollinator sharing. However, the proposed model suggested that increases in floral trait similarity and pollinator sharing negatively affect native pollination success. Our results also showed that increased pollinator sharing between native and alien plants increases pollination success, suggesting a facilitative effect of alien on native plants. Overall, our results highlight the importance of considering floral trait similarity and pollinator sharing in mediating the complex dynamic of HP transfer between native and alien plants and its consequences on native pollination success with implications for plant invasion success.
Morphologic and gene expression changes in Korean thyroid cancer cell lines under simulated ground-based microgravity
Authors: Yi Jin Wook , Ahn Jong-hyuk , yeon Park sung , Hwang young mi , Choi Yun Suk
Published: August 2023

Microgravity in space impacts human health. In particular, thyroid cancer, which has a high incidence rate, has been the subject of numerous studies with respect to microgravity. However, most studies have focused on European follicular thyroid cancer cell lines, while data regarding the effects of microgravity on Asian cell lines are lacking. Therefore, we aimed to investigate the effect of simulated ground-based microgravity on two Korean thyroid cancer cell lines, namely SNU-790 and SNU-80. We found that both cell lines formed multicellular spheroids under simulated microgravity. Gene expression analysis revealed that in SNU-790 cells, histone-related genes were upregulated and microRNA-related genes were downregulated. Meanwhile, in SNU-80 cells, genes related to the cellular response to hypoxia were downregulated. These findings contribute to a better understanding of the effects of microgravity on thyroid cancer cells. Further validation studies and clinical significance analyses are needed to fully understand the implications of these findings.
Evaluate the value of prolonging the duration of tiopronin for injection administration in preventing hepatotoxicity
Authors: yang Hongye , Lin Mingzhu , Liu Mengxing , Gu Huawei , Li Dan , Shi Yu , Hou Xidong
Published: August 2023

purpose：As part of supportive therapy, prophylaxis with tiopronin for injection (TI) against common hepatotoxicity complications has often been used. However, methods to prevent hepatotoxicity have not been established. Therefore, we analyzed the relationship between the periods of TI prophylaxis and its efficacy in preventing hepatotoxicity,evaluate the value of prolonging the duration of TI administration in preventing hepatotoxicity in gynecological cancer patients.
Methods This is a retrospective study. During 2022.1–2023.3, 452 patients with gynecological cancer patients were included in this study，the patient had normal liver function tests before treatment. The influencing factors of liver toxicity after treatment were analyzed, and different subgroups were divided according to the influencing factors. In total sample and different subgroups, we evaluated the prophylactic efficacy of TI by comparing the number of days of TI use. and the difference of the number of days of TI use on the prognosis of patients was compared in the total samples.
Results In total samples, there was no significant difference the effectiveness of TI with different prevention days for hepatotoxicity (P>0.05), and there was no significant difference in prognosis of tumor (P>0.05). The influencing factors of hepatotoxicity were the combinations of chemotherapeutic drugs,duration of chemotherapy drug use and the previous hepatotoxicity of patients. In different subgroups, there was no significant difference the effectiveness of TI with different prevention days for hepatotoxicity (P>0.05).
Conclusion TI is used as prophylactic drug in gynecological cancers, and prolonging periods of administration has no clinical value in preventing hepatotoxicity.
A novel application method of dung in restoring a degraded meadow steppe of Northern China
Authors: Hou Longyu , Bai Wenming , Sun Hailian , Liu Yahong , Luo Yingluo , Ma Xianxin , Tian Guiyun , Yu Hongxin , Liu Dewei , Li Aimin , Zhang Wen-Hao
Published: August 2023

The rapid increase in amount of dung by intensive livestock feeding has caused serious environmental problems. Natural grasslands are limited by nutrients’ availability while the dung contains nutrients that cannot be directly used by plants. The lack of effective way to release the plant available nutrients from dung greatly limits the use of dung in an environmentally friendly way. We developed a novel methodology to effectively use dung in restoration of degraded grasslands by applying dung with urea and decomposition inducer in a field experiment. We further explored the mechanisms underlying the positive effect of the combined application of dung, urea and the inducer on a degraded grassland by monitoring changes in soil, plant and community characteristics for three consecutive years under combined application of urea and dung (UD), urea, dung and decomposition inducer (UDI), and no application as control (CK) in a degraded meadow steppe in Northern China. Application of UD and UDI significantly increased soil moisture, soil total nutrients, available macronutrients, and vegetation indexes. Soil nutrients and vegetation indexes were significantly higher by application of UDI than that of UD. Soil moisture was found to be a main driving factor in aboveground biomass for each treatment. In contrast, aboveground biomass was positively related to both soil moisture and soil nutrients in each experimental year, regardless of treatments. When all data were pooled as a whole, structural equation modeling analysis indicated that the UDI-induced increase in aboveground biomass was achieved by both increasing soil moisture, and soil total nutrients and available nutrients. The inducer can accelerate dung decomposition and enhance release of nutrients from dung to soil, thus contributing to restoration of degraded grasslands. Our results demonstrate a novel way to directly use dung by combining application of urea, dung and decomposition inducer in restoration of degraded meadow steppe.
Maxillofacial trauma of equestrian origin: A retrospective study
Authors: Boiron Adeline , Barazer Camille , Clément Camille , Sahli-Vivicorsi Sonia , Bellamy Lorenn , Toux Guy Le , Boisramé Sylvie
Published: August 2023

Horse riding is a dangerous popular sport, it can causes facial traumas due to unpredictable reactions from the horse or falls. This study is a retrospective study about 20 patients. The aim of the study is analyze maxillofacial traumas with equine origin and discuss about prevention of those traumas. The admission period was from 2004 at 2021 and it takes place in emergency department of our university hospital in France. Inclusion criteria were patients who had suffered a maxillofacial trauma, admitted to the emergency department, and then to ENT and/or dentistry following an accident involving a horse. There were selected on the Health Data warehouse of our University Hospital. Thirty five medical files could be saved but 15 were not included because of the inclusion criteria. There were several studied parameters about patients: age, gender, date of injury, circumstances of injury, type of injury, management, helmet use, operative follow-up and possible sequelae. Patients were more women than men (16 versus 4), and there were young (half under 27 years old). There were more traumas in summer (80%). They concern most of the time ridder on foot (60%). 70% of the patients had at least one facial fracture. Only one case mentions helmet use. To conclude, horse riding can cause a various type of traumas. Treatments are various but sometimes surgery is necessary (only 7 of the 20 patients required just sutures). To avoid those traumas, the solution could be protective helmets, even when the ridder is on foot because in literature many of the traumas were due to lack of protective helmets.
Feedback Temperature Controller Design to a Semi-batch Hydrogenation Industrial Reactor - Part A: Modeling, Experimental Validation and Current Control System Evaluation
Authors: de Lima Fabrício Feijó , Batista Fabio Rodolfo Miguel , Guimarães Daniela Helena Pelegrine
Published: August 2023

Hydrogenation reaction normally is carried out in reactors that operate in batch or semi-batch, offering a high challenge for the implementation of efficient control systems for these processes. Therefore, the main aim of this paper was to model, simulate, validate and evaluate a real PI feedback controller applied to the control of temperature of a semi-batch industrial hydrogenation reactor. The mathematical model was considered very satisfactory since the average deviation between simulated reactor temperature and pressure and its real values were very low (0.173% and 3.74% for reactor temperature and pressure, respectively). The inlet pressures of the refrigerant and hydrogen were the main disturbs that affected the process, and the current PI controller was not able to control all the disturbances that occurred in these variables. Therefore, the development of a new control system is necessary, and will be modeled, simulated and discussed in part B of this paper.
Numerical model for calculation of Hydraulic Transients with two-phase flow and Fluid-Structure Interaction
Authors: Rocha Pedro Henrique do Nascimento , de Campos Josie Aguila Alves , Camargo Micelli Rodrigues , Rohca Marcelo da Silva
Published: August 2023

This paper presents a model for the solution of hydraulic transients with two-phase flow and fluid-structure interaction. Mathematical and numerical solutions are proposed and analyzed for the proper capture of the physical phenomena associated with the fluid compressibility and fluid celerity, which are variable in two-phase fluids, together with the disturbances generated by the fluid-structure interaction. The proposed solution for the model considers the simultaneous action of these phenomena. The developed numerical model is based on the solution of the mathematical model formed by a system of four partial differential equations, in which the necessary adaptations are integrated in fluid-structural equations and in the non-linear mathematical coefficients for the solution of the compressible and two-phase flow in question. Classical formulation is selected for the implementation of friction between fluid and pipe in the model. For the solution it is applied the method of characteristics and finite difference, with subsequent numerical integration. The validation of the results is carried out based on comparisons with experimental and analytical data.
Pre-Hospital Pulse Glucocorticoid Therapy in Patients with ST-Segment Elevation Myocardial Infarction Transferred for Primary Percutaneous Coronary Intervention: A Randomized Controlled Trial (PULSE-MI)
Authors: Madsen Jasmine Melissa , Obling Laust Emil Roelsgaard , Rytoft Laura , Folke Fredrik , Hassager Christian , Andersen Lars Bredevang , Vejlstrup Niels , Bang Lia Evi , Engstrøm Thomas , Lønborg Jacob Thomsen
Published: August 2023

Background
Inflammation in ST-segment elevation myocardial infarction (STEMI) is an important contributor to both acute myocardial ischemia and reperfusion injury after primary percutaneous coronary intervention (PCI). Methylprednisolone is a glucocorticoid with potent anti-inflammatory properties with an acute effect and is used as an effective and safe treatment of a wide range of acute diseases. The trial aims to investigate the cardioprotective effects of pulse-dose methylprednisolone administered in the pre-hospital setting in patients with STEMI transferred for primary PCI.
Methods
This trial is a randomized, blinded, placebo-controlled prospective clinical phase II trial. Inclusion will continue until 378 patients with STEMI have been evaluated for the primary endpoint. Patients will be randomized 1:1 to a bolus of 250 mg methylprednisolone intravenous or matching placebo over a period of 5 minutes in the pre-hospital setting. All patients with STEMI transferred for primary PCI at Rigshospitalet, Copenhagen University Hospital, Denmark will be screened for eligibility. The main eligibility criteria are age ≥ 18 years, acute onset of chest pain with < 12 hours duration, STEMI on electrocardiogram, no known allergy to glucocorticoids or no previous coronary artery bypass grafting, previous acute myocardial infarction in assumed culprit, or a history with previous maniac/psychotic episodes. Primary outcome is final infarct size measured by late gadolinium enhancement on cardiac magnetic resonance (CMR) three months after STEMI. Secondary outcomes compromise key CMR efficacy parameters, clinical endpoints at three months, the peak of cardiac biomarkers, and safety.
Discussion
We hypothesize that pulse-dose methylprednisolone administrated in the pre-hospital setting decreases inflammation, and thus reduces final infarct size in patients with STEMI treated with primary PCI.
Trial registration
EU-CT number: 2022-500762-10-00; Submitted May 5, 2022. ClinicalTrials.gov Identifier: NCT05462730; Submitted July 7, 2022, first posted July 18, 2022
Gamma-Aminobutyric Acid Type A Receptor Encephalitis Primarily Manifesting as Cognitive Dysfunction and Subclinical Epilepsy: A Case Report and Literature Review
Authors: Li Jin Yao , Yang Xin , Huang Zhi Qiang , Tu Min , Wang Peng Li , Xiong Cheng , Liu Quan Sheng
Published: August 2023

Background: Anti-γ-aminobutyric acid type A receptor (anti-GABAA R) encephalitis is a neurological disorder that primarily manifests as cognitive dysfunction and seizures. Affected patients rarely present with subclinical epilepsy; thus, they are prone to misdiagnosis and underdiagnosis due to a lack of available tests during early disease stages.
Case presentation: An 83-year-old male presented with a 20-day history of progressively worsening hypomnesis. On admission, cognitive dysfunction was indicated based on a Simple Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) scores of 8 and 4, respectively. Electroencephalography (EEG) showed paroxysmal spike-slow complex wave bursts in all regions, and cerebrospinal fluid was positive for anti-GABAA R β3 antibodies (titer 1:3.2). The patient was diagnosed with anti-GABAA acid A encephalitis and treated with methylprednisolone sodium succinate, gamma globulin, and mycophenolate mofetil capsules. After treatment, hypomnesis gradually improved, and EEG findings transitioned from paroxysmal spike-slow complex wave bursts in various regions to clusters of predominantly theta and delta waves. Thereafter, the patient was discharged from the hospital. After discharge, the patient continued taking oral methylprednisolone and mycophenolate mofetil capsules, but self-discontinued methylprednisolone after one month. At the five-month follow-up, the hypomnesis was significantly improved, and MMSE and MoCA scores were 18 and 14, respectively, revealing moderate cognitive impairment.
Conclusions: Anti-GABAA R encephalitis manifesting clinically as cognitive dysfunction and subclinical epilepsy is rare. Therefore, early, comprehensive, and meticulous ancillary examinations with timely and effective treatment planning are crucial for improving the duration of recovery and prognosis of the disease.
Comparative Analysis of Three Types of Whey as Substrate for Fermentation by Kluyveromyces marxianus and its Influence on Isoamyl Acetate Synthesis
Authors: Hernández-Cruz Miguel Ángel , Cadena-Ramírez Arturo , Castro-Rosas Javier , Páez-Lerma Jesús Bernardo , Ramírez-Vargas María del Rocío , Rangel-Vargas Esmeralda , Romo-Gómez Claudia , Lara-Gómez Ariadna Bárbara , Conde-Báez Laura , Gomez-Aldapa Carlos Alberto
Published: August 2023

Whey, the main byproduct in cheese manufacturing, has a high organic content, predominantly due to its lactose amount (45-60 g/L). There are three types of residues coming from cheese production: sweet whey (SW), acid whey (AW), and ricotta whey (RW). Each one presents physicochemical particularities that pose challenges when handled by small and medium enterprises, due to their costly treatment. An alternative to address this issue is the fermentation of such substrates to obtain value-added products. The goal of this research was to evaluate the fermentation with Kluyveromyces marxianus in the three types of raw whey for the production of isoamyl acetate, a compound responsible for the banana aroma. Several factors were analyzed: cellular growth, pH variations, reduction in lactose content, ethanol production, and isoamyl acetate generation. Cellular growth showed no significant differences between the three types of whey. Regarding pH, a decrease was recorded during the first 48 hours down to an approximate value of 4.3, then it increased to reach values close to 7. In acid whey, 50.95 g/L of ethanol was obtained at 120 hours. On the other hand, the maximum observed production of isoamyl acetate was 160 mg/L. Finally, the maximum lactose consumption was observed in sweet whey, with an approximate percentage of 76% at 24 hours, higher than that of acid and ricotta whey, which ranged between 56 and 58%.
Association and Path Analyses amongMorpho-agronomic Traits, Fatty Acids Contents and Oil Yield in Linseed (Linumussitatisimum L.) Genotypes in Ethiopia
Authors: Ghiday Tadesse , Mohamed Wassu , Tsehaye Yemane , Wakjira Adugna , Daba Chemeda , Dissasa Tesfaye
Published: August 2023

The improvement for a trait of interest can be achieved by both direct and indirect selection of characters that are more heritable and easy to select. The aim of this study was to determine the degree and nature of associations among morphoagronomic taits, fatty acid contents and oil yield. One hundred twenty six (120 accessions and six improved varieties) linseed (Linum usitatissimum L.) genotypes were evaluated for their morphoagronomic taits, fatty acid contents and oil yield using a Alpha lattice Design with two replications at farm fields of Holeta agricultural research center (HARC) and Kulumsa agricultural research center (KARC) during 2019/2020 cropping season in Ethiopia. At genotypic and phenotypic levels seed yield per plant had highly significant positive correlations with plant height, number of primary braches per plant, number of secondary braches per plant, number of capsules per plant, number of seeds per capsule, thousand seed weight, biological yield per plant and oil yield per plant, indicating that selection based on these parameters would considerably enhance seed yield per plant. Oil yield per plant had positive and highly significant phenotypic and genotypic correlation coefficients with plant height, number of primary branches, number of secondary branches, number of capsules per plant, number of seeds per capsule, thousand seed weight, biological yield per plant, linolenic fatty acid andseed yield per plant, indicating that selection based on these parameters would considerably enhance oil yield per plant. Biological yield per plant and seed yield per plant revealed positive and the highest direct effect on seed yield per plant and oil yield per plant, respectively. Selection to improve seed yield and oil yield per plant will be effective through biological yield per plant and seed yield per plant, respectively.
Urgent Needs for Second Life Using and Recycling Design of Wasted E-car Lithium-ion Battery: A Scientometric Analysis
Authors: Zahoor Aqib , Kun Róbert , Mao Guozhu , Farkas Ferenc , Sápi András , Kónya Zoltán
Published: August 2023

By 2030, 12–13 million tons of used electric vehicle batteries (EVBs) will reach the end of their service life, after 1st life cycle of these batteries still 60–70% of their energy storage capacity and can be first is reused for “2nd life” purpose (SLB) up to 5 to 10 years as stationary instruments before sending to recycling and extracting of valuable contents in the end-life processes (ELB). This research used bibliometrics analysis, combine with social and S-curve analysis to quantitatively analyze 4,810 SCI and SSCI databases articles from 2001 to 2021 related to SLBs and ELBs of used EVBs. Results reveal that: (1) In last 20 years publications on SLBs and recycling have been continually increasing. (2) China had highest 645 publications, secondly Germany with 635 publications, and U.S.A at thirdly with 634 publications. Several countries are providing facilities and finding ways to commercialize SLBs after 1st used. Our assessment on application of SLBs in stationary purposes the storage of solar and wind energy are promising systems, (3) keywords and S-Curve analysis for ELB articles illustrate that hydrometallurgy and biometallurgical were the top recycling technologies and attached with great potential soon. According to the EU commission and release battery directive, hydrometallurgical is the powerful and best recycling method. Finally, we provide comprehensive assessment of both SLBs and ELBs such as economic and environmental benefits, commercial and domestic applications, recycling steps, and low GHGs (i.e., greenhouse gas) emission. Our analyses and information will benefit for decision makers and researchers for present and future opportunities in this field.
Hyperuricemia and the risk of stroke incidence and mortality: a systematic review and meta-analysis
Authors: Jiang Haiyan , Su Yunyi , Liu Ruixue , Lin Yapeng , Yi Si , Zhai Xi , Huang Chunmei , Yang Jie
Published: August 2023

Background.
The relationship between hyperuricemia (HUA) and stroke remains controversial. The aim of this systematic re-view was to assess the association between hyperuricemia and stroke.
Methods.
PubMed, Embase, Web of Science and Cochrane Library were searched from their earliest records to June 5th, 2023, additional papers were identified through a manual search. Prospective studies that provided a multivariate-adjusted estimate of the association between hyperuricemia and risk of stroke incidence and mortality, represented as relative risks (RRs) with 95% confidence intervals (CIs), were eligible.
Results.
A total of 22 studies including 770532 adults were eligible and included. Hyperuricemia was associated with a significantly increasing risk of both stroke incidence (combined RR, 1.42; 95%CI, 1.31–1.53) and stroke mortality (combined RR, 1.53; 95%CI, 1.18–1.99) in our meta-analyses. Relative risk of stroke incidence: females (combined RR, 1.67 ; 95%CI, 1.44–1.92) and males (combined RR, 1.13; 95%CI, 1.02–1.25). Relative risk of mortality: female (combined RR, 1.41 ; 95%CI, 1.31–1.52) and males (combined RR, 1.27; 95%CI, 1.20–1.34). The association between hyperuricemia and ischemic stroke (IS) (combined RR, 1.39; 95%CI, 1.31–1.47) was more significant than that of hemorrhagic stroke (HS) (combined RR, 1.13; 95%CI, 1.02–1.26).
Conclusion.
Our study verified an association between hyperuricemia and risk of stroke, which was more pronounced in females.
Comparison of ultrasound Guided saline enema (USGSE) and X-ray guided air enema in the treatment of Intussusception reduction in Children
Authors: Lian Dan-Dan , Sun Chen
Published: August 2023

To compare the effect of ultrasound guided saline enema (USGSE) and X-ray fluoroscopic air enema in the reduction of intussusception in children. Eighty children with intussusception were randomly divided into ultrasonic-guided saline enema reduction in 40 cases (USGSE group) and X-ray air enema reduction in 40 cases (air enema group). The enema pressure, success rate, average time and cost of the two methods were compared. The average operation time of the USGSE group was lower than that of the air group [(5.35±1.79) min vs. (6.03±2.41) min, P=0.159], the average pressure of the air group was higher than that of the air group [(10.95±1.54) kPa vs. (9.6±1.26) kPa, P < 0.001], the success rate of resetting was higher than that of the air group (87.5% vs. 85.0%, P=0.745), and the cost of resetting was lower than that of the air group [(339.23±10.73) yuan vs. (378.23±18.20) yuan, P < 0.001]. Subgroup analysis showed that the success rate of enema treatment in children with onset time < 48 h was significantly higher than that in children with onset time ≥48 h (98.30% vs. 54.50%, continuous correction χ２=22.16, P < 0.001). The success rate and operation time of USGSE in pediatric intussusception reduction are similar to that of air enema, and the advantages of low cost and no radiation are worthy of popularization. For children with onset time ≥48 h, enema reduction is safe and effective, but the conversion rate to open is high. It is necessary to carefully identify the symptoms of intestinal perforation and necrosis on the basis of strictly following the indications to avoid delayed treatment.
Health and Wellness Characteristics of Employees Enrolled in a Workplace Wellness Study in the United Arab Emirates: A Descriptive Analysis
Authors: Mohammad Alshafi , Paulo Marília Silva , Hosani Salama Al , Jabri Omar Al , Yafei Zain Al , Datta Sonali , Koornneef Erik
Published: August 2023

Introduction: Modifiable health behaviors have the power to increase (or decrease) the risk of chronic diseases, impacting a population’s health and life span. Health and wellness programs can potentially play a major role in initiating and supporting positive changes in health behaviors, which may lead to improving an individual’s health span and reducing the risk of premature mortality. A better understanding of the health and well-being status of the population is crucial to the design of proper and effective interventions. This study aimed to describe the health and well-being status of a cohort of 123 employees in the United Arab Emirates.
Methods and analysis: This study reports the demographic characteristics, body composition, cardiovascular fitness, functional fitness, biological age, and well-being of 123 employees from a large health sector company enrolled in a workplace wellness study in the United Arab Emirates. Employees were invited to participate in an intervention that was designed to validate the efficacy of weekly health and wellness challenges. Descriptive statistics were used to describe the employees' distribution.
Results: The mean age of participants was 39.2 years old, 80% of them were non-Emirati, and the majority were from Middle-Eastern and South Asian ethnicities. The prevalence of overweight, obesity, hypercholesterolemia, hyperlipidemia, prediabetes, diabetes was 35%, 29%, 34%, 79%, 30%, 7%, respectively. Almost half of the participants (47%) were prehypertensive for systolic blood pressure, 80% had fitness category of poor-very poor, and majority (60%) reported exercising <150 minutes/week. The mean functional fitness score was 12.2 points, which indicated an increased risk of injury with physical activity.
Conclusions: The findings of this study suggest that despite the advancements in healthcare in the UAE, several key preventable risk factors are still prevalent in its population. The introduction of health and wellness programs can support healthier lifestyles to achieve improvements in quality of life and health expectancy among the UAE population.
Study on Complex Attention Between Yoga and Non-yoga Female Group
Authors: Ghosh Kaberi , Gayen Arup , Mondal Samiran
Published: August 2023

Background
Complex attention reflects the ability to control, shift, and divide attention focus, allowing for the manipulation of information and execution of multiple steps to accomplish a goal. Regular yoga practice may influence complex attention.
Aim of the study:
The present study was aimed to compare the complex attention between yoga and non-yoga group of female subjects.
Methods
A total 33 voluntary female subjects were selected for this study. To achieve the aim of the study, 12 subjects were taken from yoga group (n = 12) and 21 subjects from non-yoga group (n = 21). The age range of the subjects was 16–18 years. Yoga group underwent yoga practices regularly whereas non-yoga group follow their normal life. To collect the data paper pencil test was taken. Complex attention was measured by the following assessment namely six letter cancellation test, digit letter substitution test, digit symbol substitution test, digit span forward test, digit span backward test, trail making test part –A and B.
Results
The present study showed that yoga group was significantly better than non-yoga group of female subjects on six letter cancellation test, digit letter substitution test, digit symbol substitution test, digit span forward test, digit span backward test and trail making test part –B respectively.
Conclusion
On the basis of the result it may be concluded that the female yoga group is better than the female non-yoga group in complex attention.