bluuebunny/crossref_metadata_2025 huggingface dataset:
Yield and Fruit Properties of Husk Tomato (Physalis phyladelphica) Cultivars Grown in the Open Field in the South of West Siberia
Authors: Naumova Natalia , Nechaeva Taisia , Savenkov Oleg , Fotev Yury
Published: February 2019

Husk tomato (Physalis philadelphica Lam.) a source of functional food and medicinal compounds, has attracted renewed interest for production in temperate zones. Field-grown husk tomato yield and fruit properties and their relationship with soil chemistry and temperature were studied in the south of West Siberia, Russia, at five experimental sites. At each site, a microplot experiment with two cultivars was conducted. Basic soil chemical properties and fruit pH and dry matter, total carbon, nitrogen, and ascorbic acid content were determined. Both cultivars grew and yielded very well, producing on average 70 fruits, or 1.46 kg, per plant, with 14 mg ascorbic acid per 100 g fresh weight, 9.0% dry matter, and juice pH of 4.1. Variation in environmental conditions among sites was the major factor determining production and fruit property variation, with cultivar biology accounting for 10%. The cultivars responded differently to some soil properties, but generally their yield and fruit quality depended on soil pH and labile phosphorous and potassium. Thus, husk tomato has remarkable capacity for vigorous yields in unprotected conditions in West Siberia, despite air and soil temperatures that are much lower than in its region of origin. Detailed studies are needed to elucidate its response to varying solar radiation and atmospheric precipitation.
Implementation of the Healthy Workplace Participatory Program in a Retail Setting: A Feasibility Study and Framework for Evaluation
Authors: Strickland Jaime R. , Kinghorn Anna M. , Evanoff Bradley A. , Dale Ann Marie
Published: February 2019

Participatory methods used in Total Worker Health® programs have not been well studied, and little is known about what is needed to successfully implement these programs. We conducted a participatory health promotion program with grocery store workers using the Healthy Workplace Participatory Program (HWPP) from the Center for the Promotion of Health in the New England Workplace. We recruited a design team made up of six line-level workers and a steering committee with management and union representatives; a research team member facilitated the program. Using a formal evaluation framework, we measured program implementation including workplace context, fidelity to HWPP materials, design team and steering committee engagement, program outputs, and perceptions of the program. The HWPP was moderately successful in this setting, but required a substantial amount of worker and facilitator time. Design team members did not have the skills needed to move through the process and the steering committee did not offer adequate support to compensate for the team’s shortfall. The evaluation framework provided a simple and practical method for identifying barriers to program delivery. Future studies should address these barriers to delivery and explore translation of this program to other settings.
Association between Availability of Neighborhood Fast Food Outlets and Overweight Among 5–18 Year-Old Children in Peninsular Malaysia: A Cross-Sectional Study
Authors: Chee Cheong Kee , Yoon Ling Cheong , Kuang Hock Lim , Mohd Ghazali Sumarni , Chien Huey Teh , Che Ibrahim Mohd , Baharudin Azli , Siew Man Cheong , Yong Kang Cheah , Ahmad Noor , Yusoff Ahmad
Published: February 2019

A growing number of fast-food outlets in close proximity to residential areas raises a question as to its impact on childhood overweight and obesity. This study aimed at determining the relationship between the availability of fast-food outlets that were in close proximity to residential areas and overweight among Malaysian children aged 5 to 18 years. Measurement data on the weight and height of 5544 children (2797 boys, 2747 girls) were obtained from the National Health and Morbidity Survey 2011. Overweight (including obesity) is defined as BMI-for-age z-score > +1 SD based on the WHO growth reference. Geographic information system geospatial analysis was performed to determine the number of fast-food outlets within 1000 m radius from the children’s residential address. Multiple logistic regression was conducted to examine the association between the availability of fast-food outlets (none or more than one outlet) and overweight with adjustment for age, sex, ethnicity, monthly household income, parental educational level, residential area and supermarket density. Our results showed that the prevalence of overweight was 25.0% and there was a statistically significant association between the density of fast-food outlets and overweight (odds ratio: 1.23, 95% confidence interval: 1.03, 1.47). Our study suggested that the availability of fast-food outlets with close proximity in residential areas was significantly associated with being overweight among children. Limiting the number of fast-food outlets in residential areas could have a significant effect in reducing the prevalence of overweight among Malaysian children.
The Effect of Mechanically-Generated Vibrations on the Efficacy of Hemodialysis; Assessment of Patients’ Safety: Preliminary Reports
Authors: Hornik Beata , Duława Jan , Marcisz Czesław , Korchut Wojciech , Durmała Jacek
Published: February 2019

Muscle activity during a hemodialysis procedure improves its efficacy. We have formulated a hypothesis that vibrations generated by a specially-designed dialysis chair can, the same as physical exercise, affect the filtering of various fluids between fluid spaces during the hemodialysis procedure. This prospective and interventional study included 21 dialyzed patients. During a single dialysis session, each patient used a prototype device with the working name “vibrating chair”. The chair’s drive used a low-power cage induction motor, which, along with the worm gear motor, was a part of the low-frequency (3.14 Hz) vibration-generating assembly with an amplitude of 4 mm. Tests and measurements were performed before and after the vibration dialysis. After a single hemodialysis session including five 3-min cycles of vibrations, an increase in K t / V in relation to non-vibration K t / V ( 1.53 ± 0.26 vs. 1.62 ± 0.23 ) was seen. Urea reduction ratio increased significantly ( 0.73 ± 0.03 vs. 0.75 ± 0.03 ). A significant increase in systolic blood pressure was observed between the first and the third measurement ( 146 ± 18 vs. 156 ± 24 ). The use of a chair generating low-frequency vibrations increased dialysis adequacy; furthermore, it seems an acceptable and safe alternative to intradialytic exercise.
A Phenomenological Account of HIV Disclosure Experiences of Children and Adolescents from Northern and Southern Ghana
Authors: Appiah Seth Christopher Yaw , Kroidl Inge , Hoelscher Michael , Ivanova Olena , Dapaah Jonathan Mensah
Published: February 2019

Disclosure of HIV status to infected children, though challenged by caregiver dilemma, remains central in achieving the United Nations Programme on HIV and AIDS (UNAIDS) global goal of 90/90/90. This study explores children’s HIV disclosure experiences across Northern and Southern Ghana. A qualitative interpretative phenomenological design facilitated the recruitment of 30 HIV positive disclosed children and adolescents aged 9–19 years in 12 antiretroviral treatment (ART) centers in Northern and Southern Ghana between January 2017 and June 2018. Data was collected via in-depth interviews. We used phenomenological analysis applying concepts and categories identification, patterns and interconnections searching, mapping, theme building and constant comparative technique to draw conclusions. Disclosure of HIV status to children occurred with little or no preparation. Caregivers intentionally or out of dilemma often prolonged or postponed disclosure to when children aged older. Illness severity and disease progression principally defined the need for disclosure. Children preference for early status disclosure averaged at age 10 was demonstrated despite the initial disclosure experience of shock and disappointment. There was improved medication adherence despite the challenge of limited knowledge about HIV transmission, financial difficulty and food insecurity. Context and culturally adapted pre- and post- disclosure guideline laced with social protection package is needed to support HIV positive children.
Investigating Roundabout Properties and Bicycle Accident Occurrence at Swiss Roundabouts: A Logistic Regression Approach
Authors: Hollenstein Daria , Hess Martin , Jordan Denis , Bleisch Susanne
Published: February 2019

The positive effects of active mobility on mental and physical health as well as on air quality are widely acknowledged. Increasing the share of active travel is therefore an aim in many countries. Providing bicycle-safe infrastructure is one way to promote cycling. Roundabouts are a common traffic infrastructure and are supposed to facilitate safe and smooth traffic flow. However, data on road traffic accidents indicate an over-proportional involvement of cyclists in accidents at roundabouts. In the present study, the influence of roundabout geometry and traffic flow on bicycle accident occurrence was investigated using a logistic regression approach on twelve parameters of N = 294 mostly small- and mini-sized single-lane roundabouts in the Canton of Berne, Switzerland. Average weekday motorized traffic was identified as a major factor in explaining bicycle accident occurrence at roundabouts. Further, the radius of the central island, the location of the roundabout (in town vs. out of town) and the number of legs were significantly related to bicycle accident occurrence. While these results are in general agreement with findings from similar studies, the findings regarding the central island’s radius and the number of legs underpin the need for roundabout type-specific studies: Some parameters may not prove relevant in intermediate- to large-sized roundabouts, but become critical in small or mini roundabouts, which are common in Switzerland and numerous in the present sample.
Principles and Applications of the Global Human Settlement Layer as Baseline for the Land Use Efficiency Indicator—SDG 11.3.1
Authors: Melchiorri Michele , Pesaresi Martino , Florczyk Aneta J. , Corbane Christina , Kemper Thomas
Published: February 2019

The Global Human Settlement Layer (GHSL) produces new global spatial information, evidence-based analytics describing the human presence on the planet that is based mainly on two quantitative factors: (i) the spatial distribution (density) of built-up structures and (ii) the spatial distribution (density) of resident people. Both of the factors are observed in the long-term temporal domain and per unit area, in order to support the analysis of the trends and indicators for monitoring the implementation of the 2030 Development Agenda and the related thematic agreements. The GHSL uses various input data, including global, multi-temporal archives of high-resolution satellite imagery, census data, and volunteered geographic information. In this paper, we present a global estimate for the Land Use Efficiency (LUE) indicator—SDG 11.3.1, for circa 10,000 urban centers, calculating the ratio of land consumption rate to population growth rate between 1990 and 2015. In addition, we analyze the characteristics of the GHSL information to demonstrate how the original frameworks of data (gridded GHSL data) and tools (GHSL tools suite), developed from Earth Observation and integrated with census information, could support Sustainable Development Goals monitoring. In particular, we demonstrate the potential of gridded, open and free, local yet globally consistent, multi-temporal data in filling the data gap for Sustainable Development Goal 11. The results of our research demonstrate that there is potential to raise SDG 11.3.1 from a Tier II classification (manifesting unavailability of data) to a Tier I, as GHSL provides a global baseline for the essential variables called by the SDG 11.3.1 metadata.
Useful Flies
Authors: Suter Beat
Published: February 2019

Many molecular and cellular mechanisms that drive the physiological functions of cells or control the development of an animal are well conserved between vertebrates and insects [...]
Chemical Constituents with Leishmanicidal Activity from a Pink-Yellow Cultivar of Lantana camara var. aculeata (L.) Collected in Central Mexico
Authors: Delgado-Altamirano Ronna , López-Palma Rosa Isela , Monzote Lianet , Delgado-Domínguez José , Becker Ingeborg , Rivero-Cruz José Fausto , Esturau-Escofet Nuria , Vázquez-Landaverde Pedro A. , Rojas-Molina Alejandra
Published: February 2019

Lantana camara (L.) is employed by several ethnical groups to treat numerous diseases. Although there are no ethnomedical reports on its use against leishmaniasis, organic extracts prepared from L. camara were shown to display leishmanicidal activity. In the present study, we carried out a bioassay-guided fractionation of the dichloromethane extract from Mexican L. camara in order to identify the compounds responsible for the leishmanicidal activity. Eighteen chromatographic fractions (FI–FXVIII) were evaluated in vitro against Leishmania mexicana and L. amazonensis. FII, FX, FXI, FXV, and FXVI showed significant activity against both Leishmania strains, the most potent of which was FXV. Eicosane (1), squalene (2), β-ionone (3), caryophyllene oxide (4), β-caryophyllene (5), hexanoic acid (6), tiglic acid (7), a mixture of lantanilic (8) and camaric (9) acids, and lantadene B (10) were identified and obtained from the active fractions and evaluated for their leishmanicidal activity. The mixture of lantanilic (8) and camaric (9) acids (79%/21%) was the most potent one (half maximal inhibitory concentration (IC50) = 12.02 ± 0.36 μM). This study indicates that this cultivar of L. camara has high potential for the development of phytomedicines or as a source of natural products, which might represent lead compounds for the design of new drugs against leishmaniasis.
Adipose Tissue-Derived Mesenchymal Stem Cell Modulates the Immune Response of Allergic Rhinitis in a Rat Model
Authors: Ebrahim Nesrine , Mandour Yasser Mohammad Hassan , Farid Ayman Samir , Nafie Ebtesam , Mohamed Amira Zaky , Safwat Miriam , Taha Radwa , Sabry Dina , Sorour Safwa M. , Refae Ahmed
Published: February 2019

This study was designed to investigate the potential effects and underlying mechanism of adipose tissue-derived mesenchymal stem cells (MSCs) on allergic inflammation compared to Montelukast as an antileukotriene drug in a rat model of allergic rhinitis (AR). The effect of MSCs was evaluated in albino rats that were randomly divided into four (control, AR, AR + Montelukast, and AR + MSCs) groups. Rats of AR group were sensitized by ovalbumin (OVA) and then challenged with daily nasal drops of OVA diluted in sterile physiological saline (50 μL/nostril, 100 mg/mL, 10% OVA) from day 15 to day 21 of treatment with/without Montelukast (1 h before each challenge) or MSCs I/P injection (1 × 106 MCSs; weekly for three constitutive weeks). Both Montelukast and MSCs treatment started from day 15 of the experiment. At the end of the 5th week, blood samples were collected from all rats for immunological assays, histological, and molecular biology examinations. Both oral Montelukast and intraperitoneal injection of MSCs significantly reduced allergic symptoms and OVA-specific immunoglobulin E (IgE), IgG1, IgG2a and histamine as well as increasing prostaglandin E2 (PGE2). Further analysis revealed that induction of nasal innate cytokines, such as interleukin (IL)-4 and TNF-α; and chemokines, such as CCL11 and vascular cell adhesion molecule-1 (VCAM-1), were suppressed; and transforming growth factor-β (TGF-β) was up-regulated in Montelukast and MSCs-treated groups with superior effect to MSCs, which explained their underlying mechanism. In addition, the adipose tissue-derived MSCs-treated group had more restoring effects on nasal mucosa structure demonstrated by electron microscopical examination.
Insulin Resistance and Oxidative Stress in the Brain: What’s New?
Authors: Maciejczyk Mateusz , Żebrowska Ewa , Chabowski Adrian
Published: February 2019

The latest studies have indicated a strong relationship between systemic insulin resistance (IR) and higher incidence of neurodegeneration, dementia, and mild cognitive impairment. Although some of these abnormalities could be explained by chronic hyperglycaemia, hyperinsulinemia, dyslipidaemia, and/or prolonged whole-body inflammation, the key role is attributed to the neuronal redox imbalance and oxidative damage. In this mini review, we provide a schematic overview of intracellular oxidative stress and mitochondrial abnormalities in the IR brain. We highlight important correlations found so far between brain oxidative stress, ceramide generation, β-amyloid accumulation, as well as neuronal apoptosis in the IR conditions.
Involvement of Actin Cytoskeletal Components in Breast Cancer Cell Fusion with Human Mesenchymal Stroma/Stem-Like Cells
Authors: Melzer Catharina , von der Ohe Juliane , Hass Ralf
Published: February 2019

Cell fusion as a rare event was observed following the co-culture of human MDA-MB-231cherry breast cancer cells or benign neoplastic MCF10Acherry breast epithelial cells together with different mesenchymal stroma/stem-like cells (MSCGFP) cultures, respectively, resulting in the generation of double-fluorescing hybrid cells. Analysis of potential molecular mechanisms for the formation of cancer hybrid cells revealed cytoskeletal components, including F-actin. Thus, a sub-lethal concentration of cytochalasin D, which blocks elongation of actin filaments, was able to significantly reduce cancer hybrid cell formation. Simultaneously, cell cycle progression of the different co-cultures remained unaffected following treatment with cytochalasin D, indicating continued proliferation. Moreover, exposure to 50 nM cytochalasin D revealed little if any effect on the expression of various integrins and cell adhesion molecules in the different co-cultures. However, LC-MS proteome analysis of the different control co-cultures compared to corresponding cytochalasin-treated co-cultures demonstrated predominant differences in the expression of actin-associated cytoskeletal proteins. In addition, the requirement of structured actin to provide an appropriate cytoskeletal network for enabling subsequent fusion processes was also substantiated by the actin filament disrupting latrunculin B, which inhibits the fusion process between the breast cancer populations and mesenchymal stroma/stem-like cells (MSC). Together, these findings suggest an important role of distinct actin structures and associated cytoskeletal components during cell fusion and the formation of breast cancer hybrid cells.
From Ecology to Biotechnology, Study of the Defense Strategies of Algae and Halophytes (from Trapani Saltworks, NW Sicily) with a Focus on Antioxidants and Antimicrobial Properties
Authors: Messina Concetta Maria , Renda Giuseppe , Laudicella Vincenzo Alessandro , Trepos Rozenn , Fauchon Marilyne , Hellio Claire , Santulli Andrea
Published: February 2019

This study aimed at the characterization of the antioxidant power of polyphenol extracts (PE) obtained from the algae Cystoseira foeniculacea (CYS) (Phaeophyta) and from the halophyte Halocnemum strobilaceum (HAL), growing in the solar saltworks of western Sicily (Italy), and at the evaluation of their anti-microfouling properties, in order to correlate these activities to defense strategies in extreme environmental conditions. The antioxidant properties were assessed in the PE based on the total antioxidant activity test and the reducing power test; the anti-microfouling properties of the two PE were evaluated by measuring the growth inhibition of marine fish and shellfish pathogen bacteria as well as marine surface fouling bacteria and microalgae exposed to the fractions. Similar polyphenol content (CYS 5.88 ± 0.75 and HAL 6.03 ± 0.25 mg gallic acid equivalents (GAE) g−1 dried weight, DW) and similar reducing power percentage (93.91 ± 4.34 and 90.03 ± 6.19) were recorded for both species, even if they exhibited a different total antioxidant power (measured by the percentage of inhibition of the radical 2,2 diphenyl-1-picrylhydrazyl DPPH), with CYS (79.30) more active than HAL (59.90). Both PE showed anti-microfouling properties, being inhibitors of adhesion and growth of marine fish and shellfish pathogen bacteria (V. aestuarianus, V. carchariae, V. harveyi, P. elyakovii, H. aquamarina) and fouling bacteria (V. natriegens, V. proteolyticus, P. iirgensii, R. litoralis) with minimum inhibitory concentrations comparable to the commercial antifouling products used as a positive control (SEA-NINE™ 211N). Only CYS was a significant inhibitor of the microalgae strains tested, being able to reduce E. gayraliae and C. closterium growth (MIC 10 µg·mL−1) and the adhesion of all three strains tested (E. gayraliae, C. closterium and P. purpureum), suggesting its promise for use as an antifouling (AF) product.
Toxicological Evaluation of SiO2 Nanoparticles by Zebrafish Embryo Toxicity Test
Authors: Vranic Sandra , Shimada Yasuhito , Ichihara Sahoko , Kimata Masayuki , Wu Wenting , Tanaka Toshio , Boland Sonja , Tran Lang , Ichihara Gaku
Published: February 2019

As the use of nanoparticles (NPs) is increasing, the potential toxicity and behavior of NPs in living systems need to be better understood. Our goal was to evaluate the developmental toxicity and bio-distribution of two different sizes of fluorescently-labeled SiO2 NPs, 25 and 115 nm, with neutral surface charge or with different surface functionalization, rendering them positively or negatively charged, in order to predict the effect of NPs in humans. We performed a zebrafish embryo toxicity test (ZFET) by exposing the embryos to SiO2 NPs starting from six hours post fertilization (hpf). Survival rate, hatching time, and gross morphological changes were assessed at 12, 24, 36, 48, 60, and 72 hpf. We evaluated the effect of NPs on angiogenesis by counting the number of sub-intestinal vessels between the second and seventh intersegmental vessels and gene expression analysis of vascular endothelial growth factor (VEGF) and VEGF receptors at 72 hpf. SiO2 NPs did not show any adverse effects on survival rate, hatching time, gross morphology, or physiological angiogenesis. We found that SiO2 NPs were trapped by the chorion up until to the hatching stage. After chemical removal of the chorion (dechorionation), positively surface-charged SiO2 NPs (25 nm) significantly reduced the survival rate of the fish compared to the control group. These results indicate that zebrafish chorion acts as a physical barrier against SiO2 NPs, and removing the chorions in ZFET might be necessary for evaluation of toxicity of NPs.
Translational Control using an Expanded Genetic Code
Authors: Kato Yusuke
Published: February 2019

A bio-orthogonal and unnatural substance, such as an unnatural amino acid (Uaa), is an ideal regulator to control target gene expression in a synthetic gene circuit. Genetic code expansion technology has achieved Uaa incorporation into ribosomal synthesized proteins in vivo at specific sites designated by UAG stop codons. This site-specific Uaa incorporation can be used as a controller of target gene expression at the translational level by conditional read-through of internal UAG stop codons. Recent advances in optimization of site-specific Uaa incorporation for translational regulation have enabled more precise control over a wide range of novel important applications, such as Uaa-auxotrophy-based biological containment, live-attenuated vaccine, and high-yield zero-leakage expression systems, in which Uaa translational control is exclusively used as an essential genetic element. This review summarizes the history and recent advance of the translational control by conditional stop codon read-through, especially focusing on the methods using the site-specific Uaa incorporation.
Blind Robust 3D Mesh Watermarking Based on Mesh Saliency and Wavelet Transform for Copyright Protection
Authors: Hamidi Mohamed , Chetouani Aladine , El Haziti Mohamed , El Hassouni Mohammed , Cherifi Hocine
Published: February 2019

Three-dimensional models have been extensively used in several applications including computer-aided design (CAD), video games, medical imaging due to the processing capability improvement of computers, and the development of network bandwidth. Therefore, the necessity of implementing 3D mesh watermarking schemes aiming to protect copyright has increased considerably. In this paper, a blind robust 3D mesh watermarking method based on mesh saliency and wavelet transform for copyright protection is proposed. The watermark is inserted by quantifying the wavelet coefficients using quantization index modulation (QIM) according to the mesh saliency of the 3D semiregular mesh. The synchronizing primitive is the distance between the mesh center and salient points in the descending order. The experimental results show the high imperceptibility of the proposed scheme while ensuring a good robustness against a wide range of attacks including smoothing, additive noise, element reordering, similarity transformations, etc.
Foreword to the Special Issue: “Semantics for Big Data Integration”
Authors: Beneventano Domenico , Vincini Maurizio
Published: February 2019

In recent years, a great deal of interest has been shown toward big data. Much of the work on big data has focused on volume and velocity in order to consider dataset size. Indeed, the problems of variety, velocity, and veracity are equally important in dealing with the heterogeneity, diversity, and complexity of data, where semantic technologies can be explored to deal with these issues. This Special Issue aims at discussing emerging approaches from academic and industrial stakeholders for disseminating innovative solutions that explore how big data can leverage semantics, for example, by examining the challenges and opportunities arising from adapting and transferring semantic technologies to the big data context.
Evaluating Awareness and Perception of Botnet Activity within Consumer Internet-of-Things (IoT) Networks
Authors: McDermott Christopher D. , Isaacs John P. , Petrovski Andrei V.
Published: February 2019

The growth of the Internet of Things (IoT), and demand for low-cost, easy-to-deploy devices, has led to the production of swathes of insecure Internet-connected devices. Many can be exploited and leveraged to perform large-scale attacks on the Internet, such as those seen by the Mirai botnet. This paper presents a cross-sectional study of how users value and perceive security and privacy in smart devices found within the IoT. It analyzes user requirements from IoT devices, and the importance placed upon security and privacy. An experimental setup was used to assess user ability to detect threats, in the context of technical knowledge and experience. It clearly demonstrated that without any clear signs when an IoT device was infected, it was very difficult for consumers to detect and be situationally aware of threats exploiting home networks. It also demonstrated that without adequate presentation of data to users, there is no clear correlation between level of technical knowledge and ability to detect infected devices.
Pyriproxyfen-Treated Polypropylene Sheets and Resting Boxes for Controlling Mosquitoes in Livestock Operations
Authors: Khemrattrakool Pattarapon , Yanola Jintana , Lumjuan Nongkran , Somboon Pradya
Published: February 2019

Many insect vector species of medical and veterinary importance are found abundantly in areas where animals are held. In these areas, they often rest for a period of time on objects around the animals both before and after blood feeding. However, the use of neurotoxic insecticides for vector control is not advised for use in such shelters as these chemicals can pose hazards to animals. The present study evaluated the efficacy of pyriproxyfen (PPF), an insect growth regulator, applied to polypropylene sheets and resting boxes on the reproductivity of mosquitoes found in animal shelters in Chiang Mai, Thailand. The sheets sprayed with 666 mg PPF/m2 were set on the inner wall of a cowshed and kept in place for 3 h (6.00 to 9.00 pm). During this time, fully blood-fed female mosquitoes that landed and remained continuously on the sheets for 5, 10, and 20 min were collected. The results, involving Anopheles subpictus, An. vagus, Culex gelidus, Cx. tritaeniorhynchus, and Cx. vishnui, revealed significant reductions in oviposition rates, egg hatchability, pupation, and adult emergence in the PPF-treated groups compared to the control groups. Adult emergence rates were reduced to 85.6–94.9% and 95.5–100% in those exposed for 10 and 20 min, respectively. The sheets retained their effectiveness for three months. The PPF-treated (666 mg/m2) resting boxes (35 × 35 × 55 cm) were placed overnight at a chicken farm where Cx. quinquefasciatus predominated. Blood-fed mosquitoes were collected in the morning and reared in the laboratory. Oviposition rates were reduced by 71.7% and adult emergence was reduced by 97.8% compared to the controls. PPF residual spray on surface materials in animal sheds is a potential method for controlling mosquitoes. Further studies are needed to evaluate the impact of PPF-treated materials on wild populations.
The Emerging Role of Robotic Surgery among Minimally Invasive Surgical Approaches in the Treatment of Hypopharyngeal Carcinoma: Systematic Review and Meta-Analysis
Authors: De Virgilio Armando , Iocca Oreste , Malvezzi Luca , Di Maio Pasquale , Pellini Raul , Ferreli Fabio , Cugini Giovanni , Colombo Giovanni , Spriano Giuseppe
Published: February 2019

The aim of this systematic review with meta-analysis was to investigate the available literature on transoral approaches in the treatment of hypopharyngeal squamous cell carcinoma, with a special focus on transoral robotic surgery (TORS). A systematic review was conducted according to the PRISMA (preferred reporting items for systematic reviews and meta-analyses) check-list, and 15 studies were included. Five of the included studies evaluated TORS, while ten studies focused on transoral laser microsurgery (TLM) for the treatment of early or advanced stage hypopharyngeal cancer. Overall, survival rates of TLM and TORS studies, analyzed together in the cumulative meta-analysis, were 66.4% (95% confidence interval (CI) 54.3%–76.7%) at 36+ months of follow up. The TORS subgroup showed a higher cumulative survival rate (85.5%, 95% CI 55.8%–96.5%) compared to TLM (58.5%, 95% CI 46.6%–69.6%). Cumulative data showed that 29.3% (95% CI 24.0%–35.3%) of deaths were attributable to cancer. The results were similar between TLM and TORS studies. The larynx function preservation cumulative rate was 94.3% (95% CI 91.8%–96.1%). The results were similar among the two subgroups. The present review supports the use of transoral approaches in the treatment of hypopharyngeal cancer. TORS is oncologically sound and provides excellent functional results with low complication rates.
Non-Isothermal Crystallization Kinetic of Polyethylene/Carbon Nanotubes Nanocomposites Using an Isoconversional Method
Authors: Menezes Beatriz Rossi Canuto de , Campos Tiago Moreira Bastos , Montanheiro Thais Larissa do Amaral , Ribas Renata Guimarães , Cividanes Luciana de Simone , Thim Gilmar Patrocínio
Published: February 2019

Behavior studies of thermoplastic polymers during non-isothermal crystallization are extremely important since most of their properties are influenced by degree of crystallinity and the crystallization process. In general, an approach based on a model-fitting method is used to perform crystallization kinetic studies. Due to their inability to uniquely determine the reaction mode, many studies have used the isoconversional method, where it is not necessary to assume a crystallization model to obtain the kinetic parameters. Therefore, in this work, the influence of acid and octadecylamine functionalized carbon nanotubes (CNTs) in the crystallization kinetic of polyethylene (PE) was studied using an isoconversional method with differential scanning calorimetry (DSC) and polarized optical microscopy (POM). The kinetic parameters and the crystallization model were determined. The incorporation of functionalized and non-functionalized CNTs into PE did not change the Johnson-Mehl-Avrami crystallization model. However, the CNTs increased the crystallization temperature and reduced the activation energy for crystallization. In addition, the Avrami coefficient values were lower for the nanocomposites when compared to pure PE. The incorporation of CNTs accelerated the crystallization of PE, reducing the crystallite sizes and modifying their morphology.
Modeling and Simulation of Planing-Hull Watercraft Outfitted with an Electric Motor Drive and a Surface-Piercing Propeller
Authors: Xiros Nikolaos I. , Tzelepis Vasileios , Loghis Eleftherios K.
Published: February 2019

A simulation model for a prismatic hard-chine planing hull watercraft (V-shaped keel with constant deadrise) with propulsion based on a 3-phase induction motor connected directly to surface-piercing propeller (SPP) and outfitted with a motor rotational speed controller was investigated, tested, and tuned. The modularity of the model developed enables straightforward substitution of diverse and more refined modules, or even attachment of additional ones to obtain greater level of detail or simulate more complicated processes. Industry trends do suggest an increasing interest in all-electric ship development as well as the use of surface-piercing propellers for small or medium-size craft. All-electric drive plants offer distinct advantages due to their flexibility in arrangements, ability to eliminate reduction gears in many cases, low maintenance requirements and wide range of available sizes as well superb load acceptance and dynamic matching to changing operational conditions. Employing electric drives onboard small craft with planing-hulls that achieve significantly higher velocities where arrangements and maneuverability are of critical design issues is a theme that has received increased attention by designers in recent years. Refined speed regulation and tracking compounded by the feature to produce fairly constant torque across a broad speed (rpm) range enables using of unconventional thrusters such as surface-piercing propellers to small craft. By investigating towing tank test data series for a surface-piercing propeller, development of a numerical simulation tool for unconventional thrusters was demonstrated. The surface-piercing propeller simulation model, as an artificial neural network (ANN), was coupled with a 3-phase induction motor as prime mover as well as dynamic propulsion shaft model and proportional-integral-differential (PID) controller. The various sub-models were finally integrated with a sub-model implementing Savitsky’s propulsion resistance method and calculation of equilibrium trim for planing hull modeling. Simulations were conducted using full-scale real-world conditions for a high-speed small craft developed for leisure and sporting activities, rapid close-range transit, reconnaissance and surveying etc. The planing-hull watercraft considered is amenable to minor hull modifications in order to house a 50 kW electric motor and a four bladed surface-piercing propeller. Simulations performed allowed a full assessment of model functionality as well as level of detail.
A Mechanism for Securing IoT-enabled Applications at the Fog Layer
Authors: Abbas Nadeem , Asim Muhammad , Tariq Noshina , Baker Thar , Abbas Sohail
Published: February 2019

The Internet of Things (IoT) is an emerging paradigm branded by heterogeneous technologies composed of smart ubiquitous objects that are seamlessly connected to the Internet. These objects are deployed as Low power and Lossy Networks (LLN) to provide innovative services in various application domains such as smart cities, smart health, and smart communities. The LLN is a form of a network where the interconnected devices are highly resource-constrained (i.e., power, memory, and processing) and characterized by high loss rates, low data rates, and instability in the communication links. Additionally, IoT devices produce a massive amount of confidential and security-sensitive data. Various cryptographic-based techniques exist that can effectively cope with security attacks but are not suitable for IoT as they incur high consumption of resources (i.e., memory, storage and processing). One way to address this problem is by offloading the additional security-related operations to a more resourceful entity such as a fog-based node. Generally, fog computing enables security and analysis of latency-sensitive data directly at the network’s edge. This paper proposes a novel Fog Security Service (FSS) to provide end-to-end security at the fog layer for IoT devices using two well-established cryptographic schemes, identity-based encryption, and identity-based signature. The FSS provides security services such as authentication, confidentiality, and non-repudiation. The proposed architecture would be implemented and evaluated in an OPNET simulator using a single network topology with different traffic loads. The FSS performed better when compared with the APaaS and the legacy method.
Immersive Virtual Reality as an Effective Tool for Second Language Vocabulary Learning
Authors: Legault Jennifer , Zhao Jiayan , Chi Ying-An , Chen Weitao , Klippel Alexander , Li Ping
Published: February 2019

Learning a second language (L2) presents a significant challenge to many people in adulthood. Platforms for effective L2 instruction have been developed in both academia and the industry. While real-life (RL) immersion is often lauded as a particularly effective L2 learning platform, little is known about the features of immersive contexts that contribute to the L2 learning process. Immersive virtual reality (iVR) offers a flexible platform to simulate an RL immersive learning situation, while allowing the researcher to have tight experimental control for stimulus delivery and learner interaction with the environment. Using a mixed counterbalanced design, the current study examines individual differences in L2 performance during learning of 60 Mandarin Chinese words across two learning sessions, with each participant learning 30 words in iVR and 30 words via word–word (WW) paired association. Behavioral performance was collected immediately after L2 learning via an alternative forced-choice recognition task. Our results indicate a main effect of L2 learning context, such that accuracy on trials learned via iVR was significantly higher as compared to trials learned in the WW condition. These effects are reflected especially in the differential effects of learning contexts, in that less successful learners show a significant benefit of iVR instruction as compared to WW, whereas successful learners do not show a significant benefit of either learning condition. Our findings have broad implications for L2 education, particularly for those who struggle in learning an L2.
Nonlinear Acoustic Modeling and Measurements during the Fatigue Process in Metals
Authors: Lyu Wenhan , Wu Xianmei , Xu Weijiang
Published: February 2019

The nonlinear spring model combined with dislocation dipole theory was applied to describe the acoustic nonlinearity during the fatigue process in metals. The spring stiffness changes with fatigue degree. For the early stage, spring stiffness approaches infinity, and the heavier nonlinearity mainly results from the increase of dislocation density. Further fatigue leads to the occurrence of micro-cracks, during which spring stiffness begins to decrease. Abundant micro-crack sprouting accelerates the crack’s expansion, and spring stiffness drops quickly, which causes the obvious decline in the transmitted harmonic amplitudes. Solutions obtained from the nonlinear wave equation with dislocation terms were added into the spring model. Varying spring stiffness was chosen for simulating the fatigue process. Then, nonlinear harmonic variation during this process was observed, which was classified into three stages: (I) the early dislocation fatigue stage; (II) the micro-crack sprouting stage; (III) the crack expansion stage. Nonlinear acoustic measurements were carried out on an aluminum alloy specimen during its fatigue process until cracks could be seen clearly. Harmonic variations in experiments can also be classified into the same three stages as the numerical results, which provides a theoretical and experimental reference for fatigue evaluation in metals using the nonlinear acoustic method.
Thermal, Mechanical, and Microstructural Study of PBO Fiber during Carbonization
Authors: Hao Weizhe , Zhang Xuejun , Tian Yanhong
Published: February 2019

Poly(p-phenylene benzobisoxazole) (PBO) fiber shows fascinating properties including excellent mechanical performance, high crystallinity, and fairly good heat resistance as a kind of polymer fiber. Its properties make it a possible candidate as a precursor of carbon fiber. This paper mainly investigates the possibility of yielding carbon fiber from PBO by direct carbonization using a continuous process and multiple properties of yielded fiber treated under different heat treatment temperature (HTT). The results show that PBO fiber was able to sustain an HTT as high as 1400 °C under the inert atmosphere and that the shape of fiber was still preserved without failure. Using thermal gravimetric analysis (TGA) and TGA coupled with mass spectroscopy (TGA-MS), it was found that a significant mass loss procedure happened around 723.3 °C, along with the emission of various small molecules. The mechanical performance first suffered a decrease due to the rupture of the PBO structure and then slightly increased because of the generating of graphite crystallite based on the broken structure of PBO. It was observed that PBO’s microstructure transformed gradually to that of carbonaceous material, which could be the reason why the change of mechanical performance happened.
Johnson Cook Material and Failure Model Parameters Estimation of AISI-1045 Medium Carbon Steel for Metal Forming Applications
Authors: Murugesan Mohanraj , Jung Dong
Published: February 2019

Consistent and reasonable characterization of the material behavior under the coupled effects of strain, strain rate and temperature on the material flow stress is remarkably crucial in order to design as well as optimize the process parameters in the metal forming industrial practice. The objective of this work was to formulate an appropriate flow stress model to characterize the flow behavior of AISI-1045 medium carbon steel over a practical range of deformation temperatures (650–950 ∘ C) and strain rates (0.05–1.0 s − 1 ). Subsequently, the Johnson-Cook flow stress model was adopted for modeling and predicting the material flow behavior at elevated temperatures. Furthermore, surrogate models were developed based on the constitutive relations, and the model constants were estimated using the experimental results. As a result, the constitutive flow stress model was formed and the constructed model was examined systematically against experimental data by both numerical and graphical validations. In addition, to predict the material damage behavior, the failure model proposed by Johnson and Cook was used, and to determine the model parameters, seven different specimens, including flat, smooth round bars and pre-notched specimens, were tested at room temperature under quasi strain rate conditions. From the results, it can be seen that the developed model over predicts the material behavior at a low temperature for all strain rates. However, overall, the developed model can produce a fairly accurate and precise estimation of flow behavior with good correlation to the experimental data under high temperature conditions. Furthermore, the damage model parameters estimated in this research can be used to model the metal forming simulations, and valuable prediction results for the work material can be achieved.
Efficient Fabrication of Polycaprolactone Scaffolds for Printing Hybrid Tissue-Engineered Constructs
Authors: Sodupe Ortega Enrique , Sanz-Garcia Andres , Pernia-Espinoza Alpha , Escobedo-Lucea Carmen
Published: February 2019

Hybrid constructs represent substantial progress in tissue engineering (TE) towards producing implants of a clinically relevant size that recapitulate the structure and multicellular complexity of the native tissue. They are created by interlacing printed scaffolds, sacrificial materials, and cell-laden hydrogels. A suitable biomaterial is a polycaprolactone (PCL); however, due to the higher viscosity of this biopolymer, three-dimensional (3D) printing of PCL is slow, so reducing PCL print times remains a challenge. We investigated parameters, such as nozzle shape and size, carriage speed, and print temperature, to find a tradeoff that speeds up the creation of hybrid constructs of controlled porosity. We performed experiments with conical, cylindrical, and cylindrical shortened nozzles and numerical simulations to infer a more comprehensive understanding of PCL flow rate. We found that conical nozzles are advised as they exhibited the highest shear rate, which increased the flow rate. When working at a low carriage speed, conical nozzles of a small diameter tended to form-flatten filaments and became highly inefficient. However, raising the carriage speed revealed shortcomings because passing specific values created filaments with a heterogeneous diameter. Small nozzles produced scaffolds with thin strands but at long building times. Using large nozzles and a high carriage speed is recommended. Overall, we demonstrated that hybrid constructs with a clinically relevant size could be much more feasible to print when reaching a tradeoff between temperature, nozzle diameter, and speed.
Some Common Fixed Point Theorems in Ordered Partial Metric Spaces via ℱ-Generalized Contractive Type Mappings
Authors: Dhawan Pooja , Kaur Jatinderdeep
Published: February 2019

In the present work, the concept of F -generalized contractive type mappings by using C -class functions is introduced, and some common fixed point results for weakly isotone increasing set-valued mappings in the setting of ordered partial metric spaces are studied. These results improve and generalize various results existing in the literature. The effectiveness of the obtained results is verified with the help of some comparative examples.
First Hydrogenation Enhancement in TiFe Alloys for Hydrogen Storage Doped with Yttrium
Authors: Gosselin Catherine , Huot Jacques
Published: February 2019

The aim of this investigation was to improve the first hydrogenation of TiFe by adding yttrium. The compositions studied were TiFe + x wt.% Y with x = 4, 6, and 8. From electron microscopy it was found that all alloys were multiphase with a matrix of TiFe phase containing less than 0.4 at.% of Y and a secondary phase rich in yttrium. When x increased, the chemical compositions of the matrix changed and the secondary phase changed. The sample with 8% of yttrium had the fastest kinetics. The hydrogen capacity increased with the amount of Y.