bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGARUH GAYA KEPEMIMPINAN DAN BUDAYA ORGANISASI TERHADAP KINERJA KARYAWAN DI PATRA SEMARANG HOTEL & CONVENTION
Authors: Mudrik Mudrik  , Andhi supriyadi  , Dyah Palupiningtyas  , Heru Yulianto  , Krisna Tri Argo
Published: December 2021

This research was conducted at Patra Semarang Hotel & Convention which aims to analyze and explain the influence of leadership style and organizational culture on employee performance, and to find out which variables are most influential on tourist satisfaction.This research uses quantitative methods with 55 respondents. The validity and reliability test techniques, multiple regression analysis, hypothesis testing through the f test, t test, coefficient of determination and beta coefficient.The results showed that the level of testing was significant and positively influenced by the regression equation, Y = -0.005 X1 + 0.971 X2 and it was proven that the organizational culture variable had the most dominant influence on employee performance with a regression coefficient of 0.971. The conclusion from this study that of the two independent variables, organizational culture is a variable that has a positive effect on employee performance at Patra Semarang Hotel & Convention.
Clinical and parasitological assessment in mice treated with highly diluted Atropa belladonna
Authors: Sandri Patricia Flora , Portocarrero Angela Rigo , Ciupa Larissa , Da Veiga Franciele karina , Falkowski Gislaine  Falkowski Sanchez , Benvenutti Mateus Joacir , Rodrigues Willian Nascimento de Souza , Aleixo Denise Lessa , AraÃºjo Silvana Marques
Published: December 2021

Introduction: The infection by Trypanosoma cruzi is a public health problem and there is no effective treatment currently. Immunomodulatory effects of Atropa belladonna may offer benefits1 Objective: To evaluate the effect of A. belladonna in murine infection by T. cruzi. Methodology: The experiment was blind, controlled and randomized by draw. Eighty five Swiss male mice, at 8 weeks of age, were infected with 1400 blood trypomastigotes of T. cruzi Y strain (via IP) and divided into the following groups: without treatment (CI), treated with the mother tincture of A. belladonna (GTM-HN Cristiano), treated with A. belladonna 5cH (G5cH), treated with A. belladonna 6cH (G6cH), treated with A. belladonna 30cH (G30cH). Cereal alcohol 70 Â° GL was used for dilutions as well as water in final preparations (Sigma-SP-Brazil). Oral treatment, diluted with water (1mL/100mL water), offered ad libitum 48 hours before infection, available during 16h. After infection, treatment of 56/56h for 16h, until the 9th day of infection2. Parasitological parameters: Curve of parasitemia, total parasitemia (PT), Maximum Peak of Parasites (PMP), Pre-Patent Period (PPP), Patent Period (PP), and Survival. Clinical parameters: water, food, excreta, weight and temperature. Results: G6cH and G30cH groups displayed better survival rates (1.54 and 1.42 times versus IC), and higher curve of parasitemia - G6cH (p = 0.00), G30cH (p = 0.02) â€“ when compared to CI. PMP was lower in GTM (P = 0.01) and G5cH (p = 0.04) groups; PT was lower in GTM (p = 0.01), G5cH (p = 0.05) and G6cH (p = 0.05) groups when compared to CI. There was no difference in PPP and PP parameters in all groups, with a tendency of a higher PPP in G5cH and G6cH groups and lower PPP in G30cHgroup.The mice weight was higher in GTM (
Highland amphibians and extremely diluted thyroxine: pre-experiment storage at low temperature
Authors: Endler Peter Christian , Harrer Bernhard
Published: December 2021

Introduction: In the course of more than two decades of experimental work on a model with amphibians and extremely diluted thyroxine, one experiment in particular, investigating the effect of an ultra-high dilution of thyroxine (T30x) v analogously prepared water (W30x) in amphibians from highland biotopes, was found to be reproducible. A total of 22 experimental runs were performed between 1990 and 2011, 15 by the initial researchers and 7 by altogether 5 independent researchers (1-5). In most of these (the sole exception being two performed and reported by the initial team) a trend was found of T30x-animals developing more slowly than W30x-animals. Pooled T30x values obtained by the initial team were 10.1% lower than W30x values (100%) (p < 0.01), and pooled T30x values from the 5 independent researchers were 12.4% lower (p < 0.01). The purpose of this study was to test the hypothesis that storing the animals at 4Â°C prior to the experiment does not influence (i.e. inhibit) the effect of T30x. Cooling here seemed to be a promising means of facilitating the transport of the highland larvae to laboratories and of synchronizing experiments. Methods: The original protocol was followed, but animals were stored at 4Â°C for several days prior to the experiment. Results: In contrast to the majority of previous experiments, no clear trend was found of T30x values being different from W30x values, i.e. of animals developing more slowly under the influence of T30x (p > 0.05). Conclusion: This experiment failed to reproduce the previously observed inhibiting effect of ultra-high diluted thyroxine on highland amphibians. The hypothesis that storage of the animals at 4Â°C does not influence the effect of T30x could not be proven; in contrast, it may be that this intermediate cooling down of the larvae is responsible for the failure of the replication.
Two mega sand and dust storm events over northern China in March 2021: transport processes, historical ranking and meteorological drivers
Authors: Gui Ke , Yao Wenrui , Che Huizheng , An Linchang , Zheng Yu , Li Lei , Zhao Hujia , Zhang Lei , Zhong Junting , Wang Yaqiang , Zhang Xiaoye
Published: December 2021

Abstract. Although a remarkable reduction in the frequency of sand and dust storms (SDSs) in the past several decades has been reported over northern China (NC), two unexpected mega SDSs occurred on March 15–20, 2021 and March 27–29, 2021 (abbreviated as the “3.15” and “3.27” SDS events), which has reawakened widespread concern. This study characterizes the origins, transport processes, magnitudes of impact, and meteorological causes of these two SDS events using a long-term (2000–2021) dust optical depth (DOD) dataset retrieved from MODIS measurements and a comprehensive set of multiple satellite and ground-based observations combined with atmospheric reanalysis data. During the 3.15/3.27 event, the invasion of dust plumes greatly degraded the air quality over large areas of NC, reaching extremely hazardous levels, with the maximum daily mean PM10 concentration of 7058 µg m−3 (2670 µg m−3) recorded on March 15 (28). CALIOP observations show that during the 3.15 event the dust plume was lifted to an altitude of 4–8 km, and its range of impact extended from the dust source to the eastern coast of China. In contrast, the lifting height of the dust plume during the 3.27 event was lower than that during 3.15 event, which was also confirmed by ground-based Lidar observations. The MODIS-retrieved DOD data registered these two massive SDS events as the most intense episode in the same period in history over the past two decades. These two extreme SDS events were associated with both atmospheric circulation extremes and local meteorological anomalies that favored enhanced dust emissions in the Gobi Desert (GD) across southern Mongolia and NC. Meteorological analysis revealed that both SDS events were triggered by an exceptionally strong Mongolian cyclone generated at nearly the same location (along the central and eastern plateau of Inner Mongolia) in conjunction with a surface-level cold high-pressure system at the rear, albeit with differences in magnitude and spatial extent of impact. In the GD, the early melting of spring snow caused by near-surface temperature anomalies over dust source regions, together with negative soil moisture anomalies induced by decreased precipitation, formed drier and barer soil surfaces, which allowed for increased emissions of dust into the atmosphere by strongly enhanced surface winds generated by the Mongolian cyclone.
MULTICHARME: A modified Chernin-type multi-pass cell designed for IR and THz long-path absorption measurements in the CHARME atmospheric simulation chamber
Authors: Decker Jean , Fertein Éric , Bruckhuisen Jonas , Houzel Nicolas , Kulinski Pierre , Fang Bo , Zhao Weixiong , Hindle Francis , Dhont Guillaume , Bocquet Robin , Mouret Gaël , Coeur Cécile , Cuisset Arnaud
Published: December 2021

Abstract. We have developed MULTICHARME, a modified Chernin-type multi-pass cell especially designed for IR and THz long-path absorption measurements in the CHamber for Atmospheric Reactivity and Metrology of the Environment (CHARME). By measuring the output power using a near-IR diode-laser and a THz amplified multiplication chain, we have established that the effective reflectivity of MULTICHARME is better than 94 % over approximately three decades of frequency. Absorption measurements of N2O have been performed by probing highly excited rovibrational transitions in the near-IR and ground state rotational transitions at submillimetre wavelengths. In each case the linearity of the absorbance with the pathlengths was verified. Finally, we demonstrate that THz spectroscopy is able to study the isotopic composition of greenhouse polar gases such as N2O and to absolutely quantify stable (N2O) and reactive (O3) species at trace levels. Moreover, a THz monitoring at low pressure of the ozone decay in the chamber has been performed. The deduced ozone lifetime of 3.4 ± 0.1 h is shorter compared with previous measurements performed in CHARME at atmospheric pressure. For the first time, the ability of THz rotational spectroscopy to monitor, with a very high degree of selectivity, stable and reactive polar compounds at trace level in an atmospheric simulation chamber is demonstrated. However, the sensitivity of the THz monitoring needs to be improved to reach the atmospheric trace levels. For this purpose, it is necessary to figure out the baseline variations as well as possible induced by the multiple standing waves present in MULTICHARME.
Spatiotemporal responses in crop water footprint and benchmark under different irrigation techniques to climate change scenarios in China
Authors: Yue Zhiwei , Ji Xiangxiang , Zhuo La , Wang Wei , Li Zhibin , Wu Pute
Published: December 2021

Abstract. Adaptation to future climate change with limited water resources is a major global challenge to sustainable and sufficient crop production. However, the large-scale responses of crop water footprint and its associated benchmarks under various irrigation techniques to future climate change scenarios remain unclear. The present study quantified the responses of maize and wheat water footprint per unit yield (WFP, m3 t−1) and corresponding WFP benchmarks under two representative concentration pathways (RCPs) in the 2030s, 2050s, and 2080s at a 5-arc minute grid level in the case for China. The differences among rain-fed and furrow-, micro-, and sprinkler-irrigated wheat and maize were identified. Compared with the baseline year (2013), maize WFP will increase under both RCP2.6 and RCP8.5, by 17 % and 13 %, respectively, until the 2080s. Wheat WFP will increase under RCP2.6 (by 12 % until the 2080s), while decrease by 12 % under RCP8.5 until the 2080s. WFP will increase the most for rain-fed crops. Relative to rain-fed crops, micro irrigation and sprinkler irrigation result in the smallest increases in WFP for maize and wheat, respectively. These water-saving managements will more effectively mitigate the negative impact of climate change. Furthermore, the spatial distributions of WFP benchmarks will not change as dramatically as those of WFP. The present study demonstrated that the visible different responses to climate change in terms of crop water consumption, water use efficiency, and WFP benchmarks under different irrigation techniques must be addressed and monitored. It also lays the foundation for future investigations into the influences of irrigation methods, RCPs, and crop types on WFP and its benchmarks in response to climate change in all agricultural regions worldwide.
Pertumbuhan dan Hasil Tanaman Selada (Lactuca sativa L.) pada Tanah Ultisol dengan Pemberian Bokashi Pelepah Kelapa Sawit
Authors: Rizali Akhmad , Nurlaila  , Septiani Maya
Published: December 2021

Selada (Lactuca sativa L.) merupakan tanaman yang memiliki nilai ekonomis yang baik. Permintaan selada terus meningkat dalam beberapa tahun terakhir. Data Base Gizi Nasional USDA (2018) menyebutkan bahwa selain sebagai bahan pelengkap nabati, dalam 100 gram selada mengandung 0,15 gram lemak, 1,36 gram protein, 2,87 gram karbohidrat, dan energi 15 kalori. Penelitian ini bertujuan untuk mengetahui pengaruh dosis bokashi terbaik terhadap pertumbuhan dan hasil tanaman selada. Penelitian ini dilakukan di Rumah Kaca Agroekoteknologi selama 3 bulan, mulai bulan Juni hingga Agustus. Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) dari faktor tunggal dan diulang sebanyak 5 kali. Perlakuan penelitian adalah pemberian bokashi dengan dosis berbeda pada media tanah dengan 5 taraf perlakuan yang terdiri dari B0 (lapisan tanah atas tanpa bokashi), B1 (lapisan tanah dengan 10 ton / ha bokashi), B2 (lapisan tanah bawah dengan 20 ton bokashi. / ha), B3 (subsoil dengan 30 ton / ha bokashi), B4 (subsoil dengan 40 ton / ha bokashi). Sehingga terdapat 5 perlakuan dalam penelitian, masing-masing perlakuan diulang sebanyak 5 kali. Jadi, dalam penelitian ini terdapat 25 unit eksperimen.
PENGETAHUAN PANEN DAN PRODUKTIVITAS TENAGA KERJA PEMANENAN KELAPA SAWIT (Elaesis guineensis Jacq) DI PT. SENTOSA KALIMANTAN JAYA
Authors: Isma Isti , Winarni Budi , Alex Taman
Published: December 2021

Penelitian ini dilatarbelakangi oleh keberhasilan panen yang didukung oleh pengetahuan pemanenan sangat diperlukan untuk dapat menyelesaikan tugas-tugas pekerjaan agar hasil kerja menjadi maksimal. Tujuan dilakukannya penelitian ini adalah untuk mengetahui katagori pengetahuan pemanenan dan menghitung seberapa besar produktivitas tenaga kerja kerja pemanen kelapa sawit di PT. Sentosa Kalimantan Jaya (SKJ). Metode penelitian yang digunakan adalah metode survai. Teknik pengolahan data penelitian menggunakan metode analisis deskriptif dengan membuat katagorisasi (lima katagori) untuk mengetahui pengetahuan tenaga kerja pemanenan melalui program Microsoft Exel. Dari hasil tabulasi pengetahuan tenaga kerja pemanenan termasuk dalam katagori baik dengan nilai 380. Jadi dapat disimpulkan bahwa pengetahuan tenaga kerja pemanenan di PT. Sentosa Kalimantan Jaya (SKJ) termasuk dalam pengetahuan yang baik dan hasil rata-rata produktivitas adalah 222 janjang/HK dengan basis 181 janjang/HK.
Potensi Kandungan Metabolit Primer Pada 10 Jenis Buah-Buahan Hutan
Authors: Salusu Heriad Daud , Nurmarini Eva , Beze Husmul , Hamka  , Yulianto
Published: December 2021

Tujuan dari penelitian ini adalah untuk mengetahui manfaat buah hutan yang dapat dimakan yang tediri dari 10 jenis buah yaitu rambai (Baccaurea motleyana), limpasu (Baccaurea lanceolatai), kapul (Baccaurea macrocarpa), manau rotan (Calamus manan Miq), sega rotan (Calamus caesius Bl.), selekop (Lepisanthes amoenea), matoa (Pometia pinnata), ramania (Bouea macrophylla Griffith), kalangkala (Litsea angulata), dan lanciqn (Ficus obscura), sebagai sumber nutrisi melalui analisis metabolit primer yang terdiri dari karbohidrat, lemak , protein, kadar udara, kadar abu,

Sampel buah untuk pengujian metabolit primer adalah buah segar dimana bahagian buah yang diuji adalah daging buahnya. Analisis kadar air menggunakan metode oven, kadar protein menggunakan metode Kjeldahl, kadar lemak dengan metode ekstraksi soxhlet dan kadar karbohidrat menggunakan metode by difference.

Hasil penelitian menunjukkan  buah pada kelompok jenis rotan atau family arecaceae (rotan manau dan rotan sega) memiliki kandungan protein lebih tinggi dari buah lainnya, sedangkan jenis buah dari family baccaurea (rambai, limpasu dan kapul) rendah pada kandungan protein dan lemak. Buah kalangkala mengandung lemak paling tinggi, diikuti buah selekop dan buah dari kelompok rotan.
An Interview with the Authors: Log-Lightning Computation, and Some Instructive Mathematical Errors
Authors: Cuyt Annie
Published: December 2021

An interview with the authors of  "Log-lightning computation of capacity and Green's function", Maple Trans. 1, 1, Article 14124 (July 2021), and the author of  "Some Instructive Mathematical Errors" Maple Trans. 1, 1, Article 14069 (July 2021). This interview was conducted by Annie Cuyt, with authors Peter Baddoo & Nick Trefethen and with Richard Brent, on Wednesday Sep 22, 2021 7am – 8am (EDT) via Zoom.
Nudo borromeo y teoría del discurso. Contribuciones para el análisis de identidades, fenómenos y procesos políticos y sociales
Authors: Fair Hernán
Published: December 2021

Este trabajo explora algunos usos innovadores de la figura del nudo borromeo de la teoría lacaniana con el objetivo de complejizar y fortalecer la investigación social desde el Análisis Político del Discurso. En la primera parte: (a) se distinguen tres modalidades discursivas de anudamiento borromeico que entrelazan lo Real, lo Simbólico y lo Imaginario a nivel espacial y temporal; (b) se distingue entre los tipos de anudamientos, su extensión, su intensidad y su tiempo de estructuración y sedimentación social; (c) se analiza la dinámica discursiva de (des)anudamiento borromeico entre Real, Simbólico e Imaginario, a través de los modos de identificación imaginarios en las fantasías ideológicas, los acontecimientos fuertemente dislocadores y los síntomas que simbolizan lo Real mediante el orden significante. En la segunda parte, se proponen algunas estrategias analíticas útiles para el estudio de identidades, fenómenos y procesos políticos y sociales y se ilustra con algunos ejemplos. En la última parte, se examinan las implicancias epistemológicas y axiológicas del uso de esta herramienta lacaniana para fortalecer la investigación social crítica desde la Teoría Política del Discurso.
Investigation of the effect of N-Acetylcysteine on colistin mic values in Acinetobacter Baumannii strains isolated from clinical samples
Authors: EKŞİ Fahriye , ERİNMEZ Mehmet
Published: December 2021

Acinetobacter baumannii is an opportunistic pathogen which colonize inpatients and cause severe infections, septic shock and death. With emergence of multi-drug resistant gramnegative species and being effective in A. baumannii infections, colistin becomes a treatment option again. N-acetylcysteine (NAC), is a mucolitic agent which used commonly in lower respiratory tract infections especially patients who have cronic respiratory disorders like Chronic obstructive pulmonary disease, cystic fibrosis and bronchiectasis. In this study we aim to investigate the effect of NAC, which commonly added in lower respiratory tract infections tratment regime, on MIC values colistin used in A. baumanni tratment. Fifty A.baumannii isolates were included in the study. The isolates were identified by automated identification system. With broth microdilution method, we investigated and compared the MIC (minimum inhibitory concentration) values of colistin and NAC+Colistin combination. Colistin MIC50 value is 0.25 μg/mL and MİK90 value is 1 μg/mL, NAC+Colistin combination MIC50 value is 0.25 μg/mL and MİK90 value is 1 μg/mL. The screening for the effectiveness of clinical drugs may provide clinical strategy to improve treatment outcomes of A. baumannii and reduce hospitalization days.
Comparing rLH with hMG in embryo transfers at the stage of blastocyst and pregnancy outcomes in poor responders
Authors: DOKUZEYLÜL GÜNGÖR Nur , YURCİ Arzu , GÜRBÜZ Tuğba , GÜNGÖR Kağan
Published: December 2021

Despite showing the beneficial effects of adding LH activity to FSH, based on the pregnancy rate (PR) in patients in the previous studies, no studies have been done to compare two different gonadotrophin preparations with activity of LH in the same group of poor responders. The present study was a single-center retrospective one conducted in January 2015 - December 2019 among 30 women under 39 years old who had reduced ovarian reserve and underwent ICSI cycles. The same patient group received rFSH combined with hMG or rLH. The ovarian stimulation cycle began on the second day of the menstrual cycle, and the initial doses of gonadotrophin were 225 IU/day rFSH in addition to 75 IU/day hMG or 75 IU/day rLH. In all cycles, a flexible antagonist protocol was used. Adding rLH significantly increased the mean number of MII oocytes and cumulus oophorus complex (COC) (p < 0.001). There was no significant difference between poor responders treated with rLH or with hMG in terms of blastocyst transfer, implantation rates and clinical pregnancy rates (p>0.05). There should be further studies to confirm the better effect of rLH addition to rFSH than hMG in young poor responders. Interventions for poor responders obviously need large, randomized studies which were designed properly, due to the lack of evidence-based treatment to date for this particular patient group.
Investigation of in vitro activity of colistin and tygecyclin against Stenotrophomonas maltophilia isolates
Authors: TANRIVERDİ ÇAYCI Yeliz , BIYIK İlknur , YILMAZ Gonca , BİLGİN Kemal , BİRİNCİ Asuman
Published: December 2021

Stenotrophomonas maltophilia has emerged as an important opportunistic pathogen, causing infections whose management is often problematic due to its inherent resistance to many antibiotics. In this study, we aimed to investigate the antimicrobial susceptibility of colistin and tygecyclin as an alternative treatment options for S. maltophilia infections. A total of 122 S. maltophilia isolates were tested. Minimum inhibitory concentration (MIC) values of colistin and tygecycline were determined by broth microdilution method. Susceptibility of TMP/SMX and levofloxacin (LVX) were determined by disc diffusion method and MIC value of ceftazidime (CAZ) was determined by using E-test. Out of 122 S. maltophilia isolates, 5 (4%) of them were resistant to TMP-SXM. MIC range was 0.125- >512 μg/ml and MIC50 64 μg/ml, MIC90 512 μg/ml for colistin. MIC range for tygecyclin was detected as 0.5- >8, MIC50 2 μg/ml and MIC90 8 μg/ml. Tygecyclin resistance was detected as 66.4% according to the EUCAST guideline and 13.1% according to the USA-FDA breakpoints. And colistin resistance was determined as 86.9% according to both guidelines.
Laboratory risk indicator for necrotising fasciitis [LRINEC] score as a tool for differentiating necrotising fasciitis from other soft tissue infections
Authors: REDDY Raghunatha , RANGASWAMY Purushothaman , RAJ Preetham , KESARI Chandrakant , SAGAR Ganesh
Published: December 2021

Necrotizing fasciitis (NF) is often fatal, characterized by extensive necrosis of the subcutaneous tissues and fascia. The present study was aimed to validate the Laboratory Risk Indicator for Necrotising Fasciitis (LRINEC) score as a tool to predict/diagnose NF and to differentiate it from other soft tissue infections depending on the score. A Prospective Observational study was conducted in ESICMC PGI MSR, Medical College Hospital, Rajajinagar, Bengaluru, from Jan 2019 to June 2020. Patients ≥18 years of age with severe soft tissue infections were included in the study. Based on the LRINEC score, the patients were categorised as low (≤5), moderate (6-7) and high risk (≥8) for the prediction of onset or diagnosis of NF. Data analysis was performed using SPSS version 21.0. A total of 55 patients were included in the study. A significant 3 association was observed Dweitpharatgmee(npt=o0f.0X4X2)X, ,LURnINivEerCsitsycorfeX(pX=X0,.0X0X01X),TCraRineiancgtiavnedPRroetseianrc(hCRHPo;spi=ta0l.,0C00it1y),,Choauenmtroyglobin (p=0.008), serum 4 sodium levels (p=0.004), serum creatinine (0.D00e1p)a,ratmndenatmopfuXtaXtiXon, F(pac=u0l.t0y0o4f).XAXmXp,uCtaityio,nCwouanstdryone in 5 cases. Only 1 mortality was observed in LRINEC high risk group with NSSTI. To conclude, LRINEC scoring system showed a better positive predictive value in identifying the onset of NF and risk strategizing of the patients with severe soft tissue infections.
A rare case: pulmonary thromboembolism and pneumothorax coexistence secondary to Covid-19 infection
Authors: ERTAN Özlem , AKKURT Esma Sevil , ŞAHİN ÖZDEMİREL Tuğçe , DEMİRÖZ Mustafa Şevki , AKINCI ÖZYÜREK Berna
Published: December 2021

Acute respiratory disease caused by a novel coronavirus (Serious Acute Respiratory Syndrome-Coronavirus-2) type that was first detected in Wuhan, Hubei Province of China, has turned into a pandemic. The disease commonly presents with fever, cough, and malaise, and typically bilateral peripheral ground-glass areas are seen in thorax computed tomography. While it may present as mild upper respiratory tract infection or pneumonia, patients may also develop pulmonary thromboembolism and pneumothorax. In our case, in a young male patient who was followed up for severe pneumonia due to COVİD-19 infection, pulmonary thromboembolism, parenchymal cysts, and pneumothorax were detected. Although pulmonary thromboembolism is a common complication, cyst formation and pneumothorax are rare. We aimed to present this case because of the coexistence of multiple pulmonary complications despite the young age of the patient.
Can we prevent falls in older individuals?
Authors: SEZİK Savaş
Published: December 2021

Falls are a major public health problem globally. Each year, 2.8 million elderly people (defined as those aged ≥65) are treated in emergency departments for fall injuries. A questionnaire containing 15 questions, prepared by researchers, was provided to patients who visited the emergency department due to falls and were aged ≥65. Patients who had fallen on the ground were included in the study group and were categorized using the following criteria: age, gender, education, socioeconomic status, life spots, falling location, chronic illnesses, previous falling episodes, cause of falls, medications used, hospital procedures undergone and the outcome of those procedures. A questionnaire was given to 159 patients that visited our emergency department as a result off all. When those patients that did not respond to the questionnaires, those who had high falls, and those who did not remember their traumas were excluded, there were 119 remaining. There were 83 female participants (69.7%) and 79.87 (SD, 7.98) were participants in the study. In our study, 21 (17.6%) patients were identified as having had previous falls. Age, gender, education status, living environment, number of drugs used, diseases and p values were compared according to old operative emoticons: 0.434, 0.855, 0.607, 0.502, 0.778, 0.324and 0.384, and there are no significant statistical differences between them. Despite the challenges mentioned above, educating people about the benefits of healthy ageing, and taking preventive measures will likely help to reduce negative outcomes in the future.
Pengaruh Penambahan Plastik LDPE Pada Campuran Aspal Beton Lapis AC-BC
Authors: Hidayati Hilda Nur , Rifqi Mirza Ghulam , Amin M. Shofi’ul
Published: December 2021

Pertumbuhan volume lalu lintas yang meningkat memberikan dampak terhadap permintaan akan pembangunan struktur perkerasan jalan dan penggunaan material yang digunakan. Oleh karena itu, diperlukan suatu material yang dapat membantu melapisi bahan agregat selain aspal agar dapat mengurangi pengaruh tersebut, contohnya bahan polimer atau plastik. Salah satu upaya yang dapat dilakukan yaitu dengan dilakukan modifikasi pengaruh penambahan plastik Low Density Poly Ethylene (LDPE) sebagai bahan tambahan dalam campuran lapis aspal beton AC-BC (Asphalt Concrete-Binder Course). Tujuan dari penelitian ini adalah untuk mengetahui bagaimana pengaruh penambahan plastik jenis Low Density Poly Ethylene (LDPE) sebagai bahan tambah campuran beraspal panas AC-BC terhadap karakteristik Marshall. Pengujian yang dilakukan antara lain pengujian agregat, pengujian aspal, pengujian plastik, dan pengujian Marshall. Perancangan campuran dilakukan dengan cara kering (dry process) menggunakan variasi kadar plastik sebesar 0%, 2%, 3%, dan 4% dengan masing-masing kadar aspal yaitu 4,5%, 5%, 5,5%, 6,0%, dan 6,5%, jumlah benda uji yang dibuat yaitu 75 benda uji. Dari hasil uji Marshall diperoleh nilai KAO sebesar 6,5% dengan variasi kadar plastik LDPE 3%. Dengan nilai stabilitas sebesar 1878,40 kg, nilai flow sebesar 3,81 mm, nilai MQ sebesar 472,5 kg/mm, nilai VFB/VFA sebesar 72,55 %, nilai VIM sebesar 4,29 %, dan nilai VMA sebesar 17,74%.
Legal Aspect of Use of Underground Space for Public Transportation
(Legal Study of Jakarta Mass Rapid Transit Project)
Authors: Syahyu Yulianto
Published: December 2021

The development activities are things that every country to realize the fulfillment of the needs and welfare of the community. Limited land area is still one of the big problems in carrying out development. The land area that does not increase, followed by the need for land that continues to increase is the cause. The type of research used is the method normative and empirical juridical research which was finally analyzed using qualitative analysis methods. Regulation of the Governor of DKI Jakarta No. 167 of 2012 about underground space and the Regulation of the Minister of Public Works No. 02/PRT/M/2014 on Guidelines for Use of Space Inside the Earth, that exists today is sufficient and accommodate the implementation of the use of space underground for the construction of the Jakarta Mass Rapid Transit (MRT). However, as a step in the future use of underground space, required regulations on the use of space underground in the form of legislation that accommodates all the needs that have not been included in the current rules.

Keywords: Underground Space Utilization, MRT Jakarta, Legal Certainty.
Strategic Formulation Analysis of Semi-Permanent Building Provider from Containers, "I-Cont."
Authors: Jones Michelle Eulalia , Wulandari Alfianida , . Ubaidillah
Published: December 2021

PT. Karya Inti Abadi Kontainer, trademark ‘I-CONT,’ is a container modification company creating business stalls with modern, practical and economical containers. We are the solution for MSME business players, which is focusing on the food and beverage industry. Aside from that, we also provide services in membership from consultation, modification containers, delivery, maintenance, service until reselling and remodification. The strategy method uses the Value Proposition Canvas, IFE, EFE, VRIO, CPM, SWOT, IE, QSPM, Porter's Generic Strategy and Lean Business Canvas Model. The results of this analysis can help to determine a suitable business model for PT. Karya Inti Abadi.

Keywords: Value Proposition Canvas, Porter's Generic Strategy, Lean Business Model Canvas, containers.
Utilization of Tax Incentives, Tax Services and Existence of Tax Sanctions on Tax Compliance in Submitting SPT and Micro Business Sustainability at Kediri City during COVID-19 Pandemic
Authors: Tohari Amin , Kurniawan Andy , Muslih Basthoumi
Published: December 2021

This study aimed to analyze the utilization of tax incentives, tax sanctions, and tax services on tax compliance in submitting SPT and analyze them on micro business sustainability in Kediri City during Covid-19 pandemic. This study was a causality research design, using quantitative approach to examined the effects between exogenous and endogenous variables. The population were all micro business entrepreneurs in Kediri City with the sample size were 130 entrepreneurs. The analysis was used Structural Equation Modeling (SEM) analysis of SmartPLS program. The results showed that uutilization of tax incentives, tax service and the existence of tax sanctions had a positive and significant effect on tax compliance. Besides, tax service had a positive and significant effect on the business sustainability, but only tax incentives and tax sanctions had a positive and negligible effect on business sustainability. Kediri City needed to continue the existence of tax incentives, supervise on tax sanctions, improve tax services and motivate micro business entrepreneurs to submitting their SPT. So that, tax revenue of local government grows as expected. Meanwhile, to maintain micro business sustainability, local government with KPP Pratama Kediri has to guide and develop micro business entrepreneurs’ knowledge about tax effects for their own benefits.

Keywords: business sustainability, tax compliance, tax incentive, tax sanctions, tax service.
L’industrie Textile-Habillement de la région Fès-Meknès face à la crise : état des lieux et réflexions managériales
Authors: SLIMANI Hamid , JOUAHRI Abdou , BENJELLOUN Sanae
Published: December 2021

L’industrie Textile-Habillement au Maroc, a été impactée par la survenue de la crise Covid-19 qui a révélé des faiblesses peu visibles en période de stabilité et qui a remis en question le management actuel des entreprises. L’objectif de cet article, est de mener une étude qualitative auprès des industriels et professionnels du Textile-Habillement de la région Fès-Meknès afin de comprendre les contraintes qui s’imposent et de réfléchir aux nouvelles règles managériales, organisationnelles et institutionnelles que ces entreprises sont en mesure de faire valoir localement et mondialement.
Mechanical ventilation regulated the differentiation and proliferation of diaphragm satellite cells
Authors: Ding Junying , Li Qian , Liang Feng , Bhattarai Salyan , Liu Qingquan
Published: December 2021

Aim: This study aimed to determine the effect of mechanical ventilation (MV) on the differentiation and proliferation of diaphragm satellite cells. Methods: Diaphragm satellite cells were isolated from C57 mice receiving 6 h of MV with optimized magnetic-activated cell sorting (MACS) approach. The cells were stained with BrdU or antibody for differentiation marker MYH3. The expression of MyoD and myogenin was detected by real-time PCR. Results: Diaphragm satellite cells were successfully isolated from mice by using MACS with a set of optimized parameters. About 1.5 × 105 cells could be harvested from a diaphragm. Upon MV, the proliferation rate of diaphragm satellite cells was decreased from 88.74% to 81.92%, while the differentiation rate was increased from 17.94% to 27.58%, compared to controls. Moreover, the expression of MyoD and myogenin were significantly upregulated upon MV. Conclusions: We established a practical method to purify diaphragm satellite cells, and demonstrated that MV regulated the differentiation and proliferation of diaphragm satellite cells.
Seed amplification assays for diagnosing synucleinopathies: the issue of influencing factors
Authors: Bellomo Giovanni , Paciotti Silvia , Gatticchi Leonardo , Rizzo Domenico , Paoletti Federico Paolini , Fragai Marco , Parnetti Lucilla
Published: December 2021

Background: The prion-like misfolding and aggregation of α-synuclein (α-syn) is involved in the pathophysiology of Parkinson’s disease and other synucleinopathies. Seed amplification assays (SAAs) are biophysical tools that take advantage on the peculiar properties of prion proteins by amplifying small amounts of aggregates in biological fluids at the expense of recombinant monomeric protein added in solution. SAAs have emerged as the most promising tools for the diagnosis of synucleinopathies in vivo. However, the diagnostic outcome of SAAs depends on the aggregation kinetics of α-syn, which in turn is influenced by several experimental variables. Methods: In our work, we analysed the impact on SAAs of some of the most critical experimental factors by considering models that describe the aggregation kinetics of α-syn. Results: We started our analysis by making simulations to understand which kinetic models could explain the aggregation kinetics of α-syn during incubation/shaking cycles. Subsequently, under shaking/incubation cycles similar to the ones commonly used in SAAs, we tested the influence of some analytical variables such as monomer concentration, presence/absence of glass beads, pH, addition of human cerebrospinal fluid, and use of detergents on α-syn aggregation. Conclusions: Our investigation highlighted how optimization and standardization of experimental procedures for α-syn SAAs is of utmost relevance for the ultimate goal of applying these assays in clinical routine. Although these aspects have been evaluated with specific SAA protocols, most of the experimental variables considered influenced very general aggregation mechanisms of α-syn, thus making most of the results obtained from our analyses extendable to other protocols.
Genome-wide comparative analysis of transposable elements in Palmae genomes
Authors: Ibrahim Mohanad A. , Al-Shomrani Badr M. , Alharbi Sultan N. , Elliott Tyler A. , Alsuabeyl Mohammed S. , Alqahtani Fahad H. , Manee Manee M.
Published: December 2021

Background: Transposable elements (TEs) are the largest component of the genetic material of most eukaryotes and can play roles in shaping genome architecture and regulating phenotypic variation; thus, understanding genome evolution is only possible if we comprehend the contributions of TEs. However, the quantitative and qualitative contributions of TEs can vary, even between closely related lineages. For palm species, in particular, the dynamics of the process through which TEs have differently shaped their genomes remains poorly understood because of a lack of comparative studies. Materials and methods: We conducted a genome-wide comparative analysis of palm TEs, focusing on identifying and classifying TEs using the draft assemblies of four palm species: Phoenix dactylifera, Cocos nucifera, Calamus simplicifolius, and Elaeis oleifera. Our TE library was generated using both de novo structure-based and homology-based methodologies. Results: The generated libraries revealed the TE component of each assembly, which varied from 41–81%. Class I retrotransposons covered 36–75% of these species’ draft genome sequences and primarily consisted of LTR retroelements, while non-LTR elements covered about 0.56–2.31% of each assembly, mainly as LINEs. The least represented were Class DNA transposons, comprising 1.87–3.37%. Conclusion: The current study contributes to a detailed identification and characterization of transposable elements in Palmae draft genome assemblies.
Short and long-term effects of high-intensity interval training applied alone or with whole-body cryostimulation on glucose homeostasis and myokine levels in overweight to obese subjects
Authors: Kozłowska-Flis Marta , Rodziewicz-Flis Ewa , Micielska Katarzyna , Kortas Jakub , Jaworska Joanna , Borkowska Andżelika , Sansoni Veronica , Perego Silvia , Lombardi Giovanni , Ziemann Ewa
Published: December 2021

Background: COVID-19 pandemic has exacerbated the problem of physical inactivity and weight gain. Consequently, new strategies to counteract weight gain are being sought. Because of their accessibility, interval training and cold therapy are the most popular such strategies. We here aimed to examine the effect of 6 units of high-intensity interval training (HIIT), applied alone or in combination with 10 sessions of whole-body cryotherapy (WBC; 3 min at –110 ∘C per session) on incretins, myokines, and adipokines levels. Materials and methods: The study involved 65 subjects (body mass index of approximately 30 kg⋅m-2). The subjects were randomly divided into training group (TR; n = 27) and training supported by WBC group (TR-WBC; n = 38). Blood samples were collected before, immediately following, and 4 weeks after the intervention. Results: Fibroblast growth factor 21 (FGF21) levels significantly increased (p = 0.03) and adiponectin levels increased in the TR group (p = 0.05) compared with those recorded in TR-WBC group 24 h after the end of experimental protocol. Beneficial changes in the lipid profile (p = 0.07), a significant drop in visfatin levels (p < 0.05), and the improvement in β-cell function (HOMA-B; p = 0.02) were also observed in the TR group in the same time point of study. While TR-WBC did not induce similar changes, it ameliorated blood glucose levels (p = 0.03). Changes induced by both interventions were only sustained for 4 weeks after treatment. Conclusion: Collectively, HIIT, alone and in combination with WBC, positively affects metabolic indicators, albeit, most likely, different mechanisms drive the beneficial effects of different treatments.
Identification of candidate biomarker EMP3 and its prognostic potential in clear cell renal cell carcinoma
Authors: Lv Qingyang , Xiao Wen , Xiong Zhiyong , Shi Jian , Miao Daojia , Meng Xiangui , Yuan Hongwei , Yang Hongmei , Zhang Xiaoping
Published: December 2021

Background: Clear cell renal cell carcinoma (ccRCC) is considered the second most common urogenital tract carcinoma, plaguing patients worldwide due to its high incidence and resistance to treatment. Thus, it is urgent to screen new biomarkers and decipher their molecular mechanisms to support early clinical diagnosis and targeted therapy of ccRCC. It is reported that epithelial membrane protein 3 (EMP3) acts as a tumor-promoting or suppressing factor in a variety of malignant tumors, but its relationship with ccRCC remains to be explored. Methods: The Cancer Genome Atlas (TCGA) and Oncomine database were utilized to screen the differentially expressed genes in ccRCC. Western blot and qPCR were used to verify the expression of our subject of interest, EMP3 in ccRCC tissues and cell lines. Next, a series of functional experiments were conducted to explore the biological functions of EMP3 in tumor cells, including cell counting kit-8, transwell, wound healing assays, Oil red O staining and triglyceride determination. Western blotting was used to explore the potential mechanism of EMP3 induced ccRCC deterioration. Finally, the TIMER2.0 database was used to explore the effect of EMP3 on tumor immune infiltration and its relationship with multiple immune checkpoints. Results: In this study, we uncovered that EMP3 was more prominently expressed in ccRCC and its expression level had a significant positive correlation with the clinical stage and histopathological grade of tumor patients. Based on the TCGA database, the Receiver operating characteristic (ROC) curves showed that EMP3 could be potentially utilized as a specific biomarker in diagnosing ccRCC patients. Meanwhile, six independent prognostic factors were determined and integrated into our nomogram, with an OS concordance index (C-index) of 0.760 (95% CI: 0.689–0.831). Furthermore, in vitro depletion of EMP3 could alleviate the proliferation, migration, invasion, and lipid storage in ccRCC cells. Mechanistically, EMP3 was shown to enhance the malignant potential of tumor cells by promoting epithelial-mesenchymal transition (EMT) and lipid accumulation. In addition, the expression of EMP3 was closely related to the infiltration of a variety of immune cells, and was positively related to PD-L1, suggesting that it may be a tight connection with tumor immune escape. Conclusions: Our results revealed that EMP3 might be a candidate biomarker and independent prognostic indicator, and related to EMT process, lipid accumulation, as well as immune infiltration in ccRCC. Targeted EMP3 therapy might be a promising and effective treatment strategy for ccRCC patients.
The potentials of short fragments of human anti-microbial peptide LL-37 as a novel therapeutic modality for diseases
Authors: Chen Keqiang , Gong Wanghua , Huang Jiaqiang , Yoshimura Teizo , Wang Ji Ming
Published: December 2021

Human cathelicidin antimicrobial peptide LL-37 (LL-37) is an antimicrobial peptide derived from its precursor protein hCAP18, which is an only cathelicidin in human. LL-37 not only serves as a mediator of innate immune defense against invading microorganisms, but it also plays an essential role in tissue homeostasis, regenerative processes, regulation of proinflammatory responses, and inhibition of cancer progression. Therefore, LL-37 has been considered as a drug lead for diseases. However, high levels of LL-37 may reduce cell viability and promote apoptosis of osteoblasts, vascular smooth muscle cells, periodontal ligament cells, neutrophils, airway epithelial cells and T cells. Recent evidence reveals that LL-37-derived short peptides possess similar biological activities as the whole LL-37 with reduced cytotoxicity. Thus, such small molecules constitute a pool of potential therapeutic agents for diseases.
The Effect of Hairdresser’ Loneliness on Work Immersion and Depression
Authors: An Eun-Su , Jin Yong-Mi
Published: December 2021

Research on the stress and loneliness felt by Hairdresser, their work immersion, and their effects on depression is as important as research on customer management and is essential for the efficient management of the beauty industry. Therefore, frequency analysis, factor analysis, reliability analysis, and regression analysis were conducted to find out the relationship between work immersion and depression of beauty workers, and a total of 295 copies were used.The results of the study are as follows.First, as loneliness increases, work immersion decreases. Second, as loneliness increases, depression increases. In order to reduce loneliness, personal time should be secured through free communication and troubleshooting through Sns and beauty communities, rest time, holidays and monthly leave guarantees, and if these improve, work immersion will increase and depression will decrease.It is expected that subsequent research will continue with various variables through age diversification and segmentation of majors in the future.
ACCOUNTING FOR NATURAL CAPITAL AS AN IMPERATIVE OF THE SOCIO-ECONOMIC PARADIGM OF FINANCIAL STATEMENTS: THE CURENT STATE AND PROSPECTS OF THE REPUBLIC OF MOLDOVA
Authors: Golochalova I.
Published: December 2021

In the context of the implementation of the concept of sustainable development, the business unit activities are interpreted as a three-component system, including the economic, social, environmental segments of the economy. This trend led to the transition to the socio-economic paradigm of financial statements, which predetermines its deep transformations, one of which is to find ways to recognize natural capital and disclosure of information on its influence on the value of the business as a whole.During the study, the author nominated hypotheses: H1 - recognition and accounting of natural capital is imperative in the context of the implementation of the socio-economic development model; N2 - current in the Republic of Moldova (PM) there is no effective methodology for the financial accounting of natural capital, as a factor in the development of the environmental subsystem of the business unit, and their rationale is given according to the scheme: the imperativeness of the institutional platform of the mechanism of business interaction and natural capital is argued when moving to social -Economic development model; The state of the designated institutional platform in the PM is analyzed; A model of recognition of natural capital on the basis of IFRS is proposed; The overall assessment of the RM financial statement system in the context of its compliance of the concept of sustainable development is given.