bluuebunny/crossref_metadata_2025 huggingface dataset:
Reassortment and genomic analysis of a G9P[8]-E2 rotavirus isolated in China
Authors: Peng Rui , Li Dandi , Wang Jindong , Xiong Guangping , Wang Mengxuan , Liu Dan , Wei Yuhang , Pang Lili , Sun Xiaoman , Li Huiying , Kong Xiangyu , Shahar Saleha , Duan Zhaojun
Published: June 2023

Objective

To isolate a prevalent G9P[8] group A rotavirus (RVA) (N4006) in China and investigate its genomic and evolutionary characteristics, with the goal of facilitating the development of a new rotavirus vaccine.

Methods

The RVA G9P[8] genotype from a diarrhea sample was passaged in MA104 cells. The virus was evaluated by TEM, polyacrylamide gel electrophoresis, and indirect immunofluorescence assay. The complete genome of virus was obtained by RT-PCR and sequencing. The genomic and evolutionary characteristics of the virus were evaluated by nucleic acid sequence analysis with MEGA ver. 5.0.5 and DNASTAR software. The neutralizing epitopes of VP7 and VP4 (VP5* and VP8*) were analyzed using BioEdit ver. 7.0.9.0 and PyMOL ver. 2.5.2.

Results

The RVA N4006 (G9P[8] genotype) was adapted in MA104 cells with a high titer (105.5 PFU/mL). Whole-genome sequence analysis showed N4006 to be a reassortant rotavirus of Wa-like G9P[8] RVA and the NSP4 gene of DS-1-like G2P[4] RVA, with the genotype constellation G9-P[8]-I1-R1-C1-M1-A1-N1-T1-E2-H1 (G9P[8]-E2). Phylogenetic analysis indicated that N4006 had a common ancestor with Japanese G9P[8]-E2 rotavirus. Neutralizing epitope analysis showed that VP7, VP5*, and VP8* of N4006 had low homology with vaccine viruses of the same genotype and marked differences with vaccine viruses of other genotypes.

Conclusion

The RVA G9P[8] genotype with the G9-P[8]-I1-R1-C1-M1-A1-N1-T1-E2-H1 (G9P[8]-E2) constellation predominates in China and may originate from reassortment between Japanese G9P[8] with Japanese DS-1-like G2P[4] rotaviruses. The antigenic variation of N4006 with the vaccine virus necessitates an evaluation of the effect of the rotavirus vaccine on G9P[8]-E2 genotype rotavirus.
Development of a reverse transcription recombinase polymerase amplification combined with lateral flow assay for equipment-free on-site field detection of tomato chlorotic spot virus
Authors: Yilmaz Salih , Batuman Ozgur
Published: June 2023

Background

Tomato chlorotic spot virus (TCSV) is an economically important, thrips-transmitted, emerging member of the Orthotospovirus genus that causes significant yield loss mainly in tomatoes, but also in other vegetable and ornamental crops. Disease management of this pathogen is often challenging due to the limited availability of natural host resistance genes, the broad host range of TCSV, and the wide distribution of its thrips vector. Point-of-care detection of TCSV with a rapid, equipment-free, portable, sensitive, and species-specific diagnostic technique can provide prompt response outside the laboratory, which is critical for preventing disease progression and further spread of the pathogen. Current diagnostic techniques require either laboratory-dependent or portable electronic equipment and are relatively time-consuming and costly.

Results

In this study, we developed a novel technique for reverse-transcription recombinase polymerase amplification combined with lateral flow assay (RT-RPA-LFA) to achieve a faster and equipment-free point-of-care detection of TCSV. The RPA reaction tubes containing crude RNA are incubated in the hand palm to obtain sufficient heat (∼36 °C) for the amplification without the need for equipment. Body-heat mediated RT-RPA-LFA is highly TCSV-specific with a detection limit as low as ∼6 pg/μl of total RNA from TCSV-infected tomato plants. The assay can be performed in 15 min in the field.

Conclusion

To the best of our knowledge, this is the first equipment-free, body-heat-mediated RT-RPA-LFA technique developed to detect TCSV. Our new system offers a time-saving advantage for the sensitive and specific diagnostic of TCSV that local growers and small nurseries in low-resource settings can use without skilled personnel.
Does robot-assisted surgery reduce leg length discrepancy in total hip replacement? Robot-assisted posterior approach versus direct anterior approach and manual posterior approach: a propensity score-matching study
Authors: Ma Mingyang , Song Ping , Zhang Shuai , Kong Xiangpeng , Chai Wei
Published: June 2023

Background

Advocates of robot-assisted technique argue that robots could improve leg length restoration in total hip replacement. However, there were few studies to compare the robot-assisted posterior approach (RPA) with conventional posterior approach (PA) THA and direct anterior approach (DAA) THA in LLD. This study aimed to determine whether robot-assisted techniques could significantly reduce LLD compared to manual DAA and manual PA.

Methods

We retrospectively reviewed the cohort of consecutive ONFH patients who underwent THA robot-assisted posterior, manual posterior, and manual DAA from January 2018 to December 2020 in one institution. One experienced surgeon performed all procedures. We calculated the propensity score to match similar patients in different groups by multivariate logistic regression analysis for each patient. We included confounders consisting of age at the time of surgery, sex, body mass index (BMI), and preoperative LLD. Postoperative LLD and Harris hip scores (HHS) at two years after surgery of different cohorts were compared.

Result

We analyzed 267 ONFH patients treated with RPA, DAA, or PA (73 RPA patients, 99 DAA patients, and 95 PA patients). After propensity score matching, we generated cohorts of 40 patients in DAA and RPA groups. And we found no significant difference in postoperative LLD between RPA and DAA cohorts (4.10 ± 3.50 mm vs 4.60 ± 4.14 mm, p = 0.577) in this study. The HHS at 2 years postoperatively were 87.04 ± 7.06 vs 85.33 ± 8.34 p = 0.202. After propensity score matching, we generated cohorts of 58 patients in manual PA and RPA groups. And there were significant differences in postoperative LLD between the RPA and PA cohorts. (3.98 ± 3.27 mm vs 5.38 ± 3.68 mm, p = 0.031). The HHS at 2 years postoperatively were 89.38 ± 6.81 vs 85.33 ± 8.81 p = 0.019. After propensity score matching, we generated cohorts of 75 patients in manual DAA and PA groups. And there were significant differences in postoperative LLD between the DAA and PA cohorts. (4.03 ± 3.93 mm vs 5.39 ± 3.83 mm, p = 0.031) The HHS at 2 years postoperatively were 89.71 ± 6.18 vs 86.91 ± 7.20 p = 0.012.

Conclusion

This study found no significant difference in postoperative LLD between RPA and DAA, but we found a significant difference between RPA and manual PA, DAA and manual PA in ONFH patients. We found a significant advantage in leg length restoration in primary total hip arthroplasty with robot-assisted surgery.
Deconstruction of a multi-strain Bacillus-based probiotic used for poultry: an in vitro assessment of its individual components against C. perfringens
Authors: Buiatte Vinicius , Schultheis Maria , Lorenzoni Alberto Gino
Published: June 2023

Objective

Probiotics have been used in poultry production to improve the performance and health of chickens raised without antibiotics. The combination of different probiotic strains has been used with the hope of conferring multiple benefits to the host. However, the inclusion of several strains does not necessarily boost benefits. There is a lack of studies that compare the efficacy of multi-strain probiotics to their individual components. In this study, the effects of a Bacillus-based probiotic product mix containing B. coagulans, B. licheniformis, B. pumilus, and B. subtilis against Clostridium perfringens were tested in vitro using a co-culture method. The individual strains and different combinations of the strains used in the product were also tested against C. perfringens.

Results

The probiotic product mix tested in this study did not show effects against C. perfringens (P = 0.499). When tested individually, the strain of B. subtilis was the most efficient strain to decrease C. perfringens concentrations (P ≤ 0.01), and the addition of other Bacillus species strains significantly decreased its efficacy against C. perfringens. We concluded that the probiotic mix of Bacillus strains used in this study (B. coagulans, B. licheniformis, B. pumilus and B subtilis) was not effective in decreasing C. perfringens concentrations in vitro. However, when deconstructing the probiotic, the strain of B. subtilis alone or combined with the strain of B. licheniformis were effective against C. perfringens. This suggests that the anticlostridial properties of the particular strains of Bacillus used in this study were negatively affected when combined with other Bacillus spp. strains.
Preferred cataract surgery practices in Malaysia: a survey based study
Authors: Wai Yong Zheng , Chong Yong Yuin , Lim Lik Thai , Chan Jan Bond , Chandrasekaran Sudhashini
Published: June 2023

Background

To describe the preferred cataract surgery practices among Malaysian ophthalmologists and medical officers in comparison with the recommended practices.

Methods

An online questionnaire was sent out in April 2021, to Malaysian Ophthalmologists and medical officers who perform cataract surgeries. The questions were focused on the preferred cataract surgery practices of the participants. All data obtained were collected, tabulated and analysed.

Results

A total of 173 participants responded to the online questionnaire. 55% of the participants were within 31–40 years of age. 56.1% preferred peristaltic pump over venturi system. 91.3% of participants practised povidone iodine instillation to the conjunctival sac. With regards to the main wound incision, more than half of the surgeons (50.3%) preferred fixed superior incision and 72.3% of them preferred 2.75 mm microkeratome blade. Most of the participants (63%) were inclined towards C-Loop clear intraocular lens (IOL) with a single-handed push preloaded system. 78.6% of the surgeons routinely use carbachol in their cataract surgery.

Conclusions

This survey provides some insight into the current practices among Malaysian ophthalmologists. Most of the practices are in line with international guidelines for preventing postoperative endophthalmitis. This article could help trainees and ophthalmologists benchmark and observe the common cataract surgery practices among their seniors and peers in Malaysia.
Chromatographic isolation of potentially novel antibiotic compounds produced by Yimella sp. RIT 621
Authors: Freezman Ian M. , Parthasarathy Anutthaman , Miranda Renata Rezende , Watts Lizabeth M. , Hudson André O.
Published: June 2023

Objective

Antibiotic resistant infections have become a global health crisis causing 1.2 million deaths worldwide in 2019 [1]. In a previous study, we identified a bacterium from a rare genus, Yimella, and found in an initial antibiotic screening that they produce broad-spectrum bactericidal compounds [2]. Herein, we focus on the characterization of these potential novel antimicrobial compounds produced by Yimella sp. RIT 621.

Results

We used solid-phase extraction and C18 reverse-phase chromatography to isolate the antibiotic-active compounds found in organic extracts from liquid cultures of Yimella sp. RIT 621. We tracked the antimicrobial activity by testing the extracts in disc diffusion inhibitory assays and observed its increase after each purification stage.
Could the use of a new novel bipolar radiofrequency device (Aerin) improve nasal valve collapse? A systematic review and meta-analysis
Authors: Casale Manuele , Moffa Antonio , Giorgi Lucrezia , Pierri Michelangelo , Lugo Rodolfo , Jacobowitz Ofer , Baptista Peter
Published: June 2023

Background

Surgical treatment for nasal obstruction caused by nasal valve collapse requires a significant recovery period and risks of complications, while nasal dilators are uncomfortable. Recently, radiofrequency treatment of lateral walls has been used under local anesthesia as an office base surgery. This work aims to assess the efficacy of a new radiofrequency device, the Vivaer™ System (Aerin Medical, Sunnyvale, CA), to treat nasal obstruction through a systematic review and meta-analysis.

Methods

Two researchers independently reviewed the literature up to December 2021. Studies on patients seeking treatment for nasal obstruction due to nasal valve collapse were included in the analysis.

Results

Four studies (218 patients) met the inclusion criteria and treated the nasal valve regions bilaterally with the Aerin Medical Vivaer™ System. After the treatment, the NOSE score was reduced at three months postoperatively. Minor adverse events were reported in the included studies, and two showed no complications. None of the studies reported changes in the external appearance of the nose.

Conclusion

The radiofrequency treatment using the Vivaer device can be useful for treating nasal valve collapse, improving significantly subjective breathing symptom scores. Further studies on a large scale are needed to confirm these results.
A case of chronic total occlusion in popliteal artery recanalized by double snare piercing technique
Authors: Miyashita Hirokazu , Tobita Kazuki , Uchida Syuhei , Koyama Eiji , Tamaki Yusuke , Yamashita Takayoshi , Saito Shigeru
Published: June 2023

Background

Although majority of cases with chronic total occlusion (CTO) in femoro-popliteal lesion were treated with antegrade approach only, some lesions require alternative approach due to its complexity. Bi-directional approach is useful on endovascular therapy (EVT) for CTO; however guidewire passage through the lesion is impossible in some challenging cases. The present case shows a successful re-entry technique utilizing two snare catheters from an antegrade and retrograde access site (double snare piecing technique).

Case presentation

A 79-year-old woman with right leg intermittent claudication (Rutherford category IV), who had undergone unsuccessful EVT for popliteal CTO, required another EVT for the worsening symptom. Following the failed conventional crossing technique (wire knuckle technique, intravascular-ultrasound-guided wiring, and controlled antegrade and retrograde subintimal tracking technique), two snare catheters were placed and the snare loops were pierced by a puncture needle percutaneously. After an 0.014 wire was inserted into the needle, the needle was withdrawn. The wire was pulled from the retrograde side and was externalized. Then, the antegrade snare catheter was pulled and externalized, to make the wire across the lesion. After that, a microcatheter was advanced along the externalized wire from the retrograde side and cross the lesion. The wire was replaced with a new wire, which completely created pull-through system. After the hemostasis by balloon inflation and lesion preparation, this procedure was completed with an endoluminal-covered stent and two inter-woven stents. The re-entry site was covered by the inter-woven stent. Her symptoms improved after the procedure, and the lesion has not developed restenosis at 2-years follow-up.

Conclusions

This re-entry technique of puncturing two snare loops (double snare piercing technique) might be effective for achieving successful passage through challenging femoropopliteal CTO cases.
Impact of 18F FDG PET/CT on management of incidental gallbladder carcinoma
Authors: Singh Man Mohan , Verma Shashwat , Kakkar Lavish , Thakur Priyamedha Bose , Deswal Satyawati
Published: June 2023

Background

Incidental gallbladder carcinoma (IGBC) is identified after cholecystectomy being performed for a presumed to be benign disease, and histopathology turns out as malignant disease. For optimal management planning, it is crucial to know the actual disease status. 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) provides local, regional as well as distant disease, i.e., restaging and identifying true burden of disease for optimal treatment planning. The aim of this study was to restage the IGBC patients on 18F FDG PET/CT and find out any change in treatment plan.

Methods

This retrospective descriptive study was performed between November 2021 and February 2023. All PET/CT scans were analyzed which came for restaging in IGBC.

Results

PET/CT was performed at a median time of 9 weeks (range 6–12 weeks) from the date of surgery. This study included 17 patients (6 males and 11 females), with a median age of 55 years (range 38–76 years). From total of 17 PET/CT scans, 10 (58.8%) patients were positive and 7 (41.1%) patients were negative on PET/CT. Among the PET/CT positive patients, disease pattern was seen in the form of local/residual disease/liver infiltration, regional lymph nodes and distant metastases. Among the 17 patients, treatment plan in 5 patients (having PET/CT negative) was changed from surgical intervention to no treatment, and in 2 patients (having PET/CT positive), treatment plan was changed to chemotherapy, i.e., total 7 (5 + 2, 41% of total 17 patients) patients’ treatment plans were changed. By reducing the number of patients undergoing re-resection, we can say that it reduces the burden on already overburdened health infrastructure, especially in developing countries like India where incident is high.

Conclusions

PET/CT provides the actual stage of IGBC. It changes treatment plan and reduces the number of patients undergoing re-resection. It also decreases burden on overburdened health infrastructure.
Modifying Summer Undergraduate Research Programs during COVID-19 Increased Graduate School Intentions but Exacerbated Anxieties
Authors: Grineski Sara E. , Morales Danielle X. , Collins Timothy W.
Published: June 2023

Data collected from U.S. undergraduate researchers in STEM during Summer 2020 is used to examine how summer undergraduate research experience (SURE) 2020 program cancellations affected student well-being in specific domains. Students whose SUREs were canceled had reduced anxiety but greater concerns about graduate school matriculation than those in modified SUREs.
Status of Government-Funded Radiotherapy Services in Nigeria
Authors: Aruah Simeon C. , Chidebe Runcie C.W. , Orjiakor Tochukwu C. , Uba Fatima , Shagaya Uchechukwu N. , Ugwanyi Charles , Umar Aisha A. , Ige Taofeeq , Asogwa Obinna C. , Ahmadu Oiza T. , Ali-Gombe Musa , Adewumi Alabi , Okwor Vitalis C. , Mutiu Jimoh A. , Bello Basheer , Eriba Lucy O. , Ahmed Yusuf A. , Bisalla Awwal , Itanyi Ukamaka , Balogun Ramatallah A. , Alabi Suleiman , Pistenmaa David , Coleman C. Norman , Manjit Dosanjh
Published: June 2023

PURPOSE

Access to radiotherapy (RT) is now one of the stark examples of global cancer inequities. More than 800,000 new cancer cases require potentially curative or palliative RT services in Africa, arguably <15% of these patients currently have access to this important service. For a population of more than 206 million, Nigeria requires a minimum of 280 RT machines for the increasing number of cancer cases. Painfully, the country has only eight Government-funded RT machines. This study aimed to evaluate the status of the eight Government-funded RT services in Nigeria and their ability to deliver effective RT to their patients.

METHODS

A survey addressing 10 critical areas was used to assess the eight Government-funded RT services in Nigeria.

RESULTS

Unfortunately, six of the eight centers (75%) surveyed have not treated patients with RT because they do not have functioning teletherapy machines in 2021. Only two RT centers have the capability of treating patients using advanced RT techniques. There is no positron emission tomography-computed tomography scan in any of the Government-funded RT centers. The workforce capacity and infrastructure across the eight centers are limited. All of the centers lack residency training programs for medical physicists and radiation therapy technologists resulting in very few well-trained staff.

CONCLUSION

As the Nigerian Government plans for the new National Cancer Control Plan, there is an urgent need to scale up access to RT by upgrading the RT equipment, workforce, and infrastructure to meet the current needs of Nigerian patients with cancer. Although the shortfall is apparent from a variety of RT-capacity databases, this detailed analysis provides essential information for an implementation plan involving solutions from within Nigeria and with global partners.
Curating with Counterpowers
Authors: Grindon Gavin
Published: June 2023

This article examines the turn in Anglophone protest cultures since 2007 toward curating, museums, and heritage: a rise in the toppling of statues, demonstrations inside museums, and the creation of exhibitions, displays, and archives within the ephemeral spaces of protest camps and other mobilizations. The author argues for the historical causes of this curatorial turn in movement cultures, examines the structural power dynamics of this extrainstitutional curating vis-à-vis the practices and policies of cultural institutions, and puts these developments in critical dialogue with recent debates on “activist curating” and “institutional liberation.” Lastly, drawing on this analysis and firsthand experiences on both sides of this dynamic (as a core member of the collective Liberate Tate and as cocurator of the V&A exhibition Disobedient Objects), the author assesses this trajectory's potentials and limits as a cultural strategy for social change.
Life outside the Labor Process
Authors: McCallum Jamie K.
Published: June 2023

This memorial essay is a personal and sociological reflection on what it was like to learn from Stanley Aronowitz, both as his student and as his friend. Close attention is paid to what many consider his best book, False Promises, and its major insight: that class consciousness forms outside the labor process — through games, play, sex, and community organizing — as much as from within it.
Two feedback mechanisms involved in the control of leaf fragment size in leaf-cutting ants
Authors: Römer Daniela , Exl Rebecca , Roces Flavio
Published: June 2023

Polymorphic leaf-cutting ants harvest leaf fragments that correlate in size with the workers' body size. When cutting, workers anchor their hind legs on the leaf edge and rotate, removing approximately semicircular fragments. Workers show behavioural plasticity and modify their leg extension while holding onto the leaf edge depending on, for instance, leaf toughness, cutting smaller fragments out of tough leaves. What sensory information workers use to control the cutting trajectory remains unknown. We investigated whether sensory information from both the leg contact with the leaf edge and from head movements underlies fragment size determination. In the laboratory, we recorded Atta sexdens workers cutting standardised ®Parafilm pseudoleaves of different thickness, and quantified cutting behaviour and body reach, i.e. the distance between the mandible and the anchored hind leg tarsus. Experimentally preventing contact with the leaf edge resulted in smaller fragments, evincing that workers control the cutting trajectory using information from the contact of the hind legs with the leaf edge. However, ants were able to cut fragments even when contact of all six legs with the edge was prevented, indicating the use of additional sensory information. Ablation of mechanosensory hairs at the neck joint alone did not influence fragment size determination, yet simultaneously preventing sensory feedback from both mechanosensory hairs and edge contact led to a loss of control over the cutting trajectory. Leaf-cutting ants, therefore, control their cutting trajectory using sensory information from both the leg contact with the leaf edge and the lateral bending of the head.
The COVID-19 third wave in Myanmar following the military coup
Authors:   Spring Research Team
Published: June 2023

Background: COVID-19 has disrupted health system of many countries, particularly worse in those resource limited settings including Myanmar. First and second waves in Myanmar during 2020 were effectively managed by the government. However, the momentum was disrupted due to the military coup in early 2021. This study aimed to analyse the situation of COVID-19 occurrence and death proportions during its third wave in Myanmar.

Methods: An online survey was conducted using a Google form. People with the symptoms of COVID-19 and those who died from COVID-19 between June-August 2021 were eligible to participate. The Google form was extracted into an Excel datasheet and analysed using Stata v16.1.

Results: Among the 29,171 participants, 76.7% were over 30 years old and 56.4% were female. A majority of participants were from highly populated regions: Yangon (17,220; 59%) (Business capital), Mandalay (3,740; 12.8%) and Sagaing (1,546; 5.3%). Participants sought health care from telegram/other online services (34%), home care by health care providers (22%), private clinics (13%) and public hospitals run under the military junta (5%). Overall, 15% of participants died, of which, 72% occurred at home and 17% at public hospitals. Significantly higher proportions of deaths were seen among participants over 60 years than other age groups and males (p<0.001). Death proportions at different weeks from June to August 2021 ranged from 12.4% to 17.3%, much higher than the military junta’s reports. Overall, 25% of participants received oxygen therapy.

Conclusions: Death proportions in different weeks were consistently high with limited access to public hospital care during the third wave.  The data suggests that COVID-19 third wave severely hit Myanmar, with adverse outcome fueled by the military coup. However, the online Telehealth clinics operated by Ministry of Health, Myanmar National Unity Government, offered the alternative accessible solution for the certain population within the country.
Statistical shape analysis of Corpus Callosum in vaginismus
Authors: Baykara Sema , Baykara Murat , Atmaca Murad
Published: June 2023

Aim of the study

Vaginismus is the presence spasm of the muscles in the vagina in the absence of any disease. Neurological diseases can cause degenerative changes in brain structures such as the corpus callosum (CC).
The aim of this study is to evaluate the corpus callosum of patients with vaginismus with statistical shape analysis (SSA) using magnetic resonance imaging (MRI) images and compare it with healthy controls.

Subject or material and methods

Ten female patients with vaginismus and healthy individuals who met the study criteria, were equal in number and age were selected as the control. Mid-sagittal T1-weighted MRI images of each individual were obtained, and the corpus callosum was marked with software on each image using anatomical landmarks, and data were collected. The mean of 'Procrustes' landmarks was calculated and shape deformations were evaluated using thin plate spline (TPS) analysis.

Results

A significant slightly difference was found in terms of corpus callosum areas in the mid-sagittal images of patients with vaginismus and controls. Maximum CC deformation was observed in almost all regions markings in those with vaginismus. In the evaluation of allometry, multivariate regression test was used for the relationship between size and shape and a statistically significant model was obtained for CC.

Discussion

CC analysis with SSA using MRI images revealed significant differences between patients and healthy subjects.

Conclusions

The study findings highlighted the abnormal distribution of white matter in the corpus callosum and the variable subregional nature of CC in vaginismus patients. This study may help future studies in terms of vaginismus etiology, diagnosis and treatment options.
El carácter y función del personaje de María Josefa en La casa de Bernarda Alba, o la locura como recurso dramático
Authors: Aszyk Urszula
Published: June 2023

En el presente artículo se estudia la función dramática de María Josefa dentro de la estructura de La Casa de Bernarda Alba. Al concederle el papel de “loca”, el autor la convierte en personaje que, a pesar de su avanzada edad, se rebela contra la tiranía de su hija Bernarda. Así estructurado el personaje se asemeja a las figuras de locos y locas presentes en el teatro español áureo y el teatro inglés isabelino.
Valores y usos de la interjección guau en la lengua española
Authors: Komorowska Agata
Published: June 2023

En el artículo se analizan los distintos usos de la interjección guau, que es, a la vez, un préstamo de la lengua inglesa. El análisis se fundamenta principalmente en los enunciados recogidos en el Corpus del Español del Siglo XXI (CORPES). Se examinan las funciones discursivas y los valores pragmáticos de guau en español.
Latent Agents in Networks: Estimation and Targeting
Authors: Ata Baris , Belloni Alexandre , Candogan Ozan
Published: June 2023

Latent Agents in Networks: Estimation and Targeting

In “Latent Agents in Networks: Estimation and Targeting,” Baris Ata, Alexandre Belloni, and Ozan Candogan address the problem of estimating network effects in a setting in which data only on a subset of agents is available. In this setting, the observable agents influence each other’s outcomes both directly and indirectly through their influence on the latent agents. Even in sparse networks, the combination of direct and indirect network effects yields a nonsparse influence structure that makes estimation challenging. The authors overcome this challenge and provide an estimation algorithm that performs well in high-dimensional settings. They also establish convergence rates for their proposed estimator and show that their performance guarantees are valid for a large class of networks. Finally, the authors demonstrate the application of their algorithm to a targeted advertising problem, in which it can be used to obtain asymptotically optimal advertising decisions despite the presence of latent agents.
An Automation Script Generation Technique for the Smart Home
Authors: Kuang Jiayi , Xue Gang , Yan Zeming , Liu Jing
Published: June 2023

A home automation system means monitoring and controlling various kinds of devices in the home remotely using the Internet of things (IoT). Technologies such as natural language processing techniques, user-friendly visual programming, and machine intelligence programming are already available for home automation. For such systems, the increase in the number of devices often makes users focused on the system’s ability to perform complex or composing tasks. However, some existing natural language processing systems can only perform simple tasks and cannot meet users’ needs. Thus, it is difficult for users to develop the home automation systems they need using visual programming systems because of the large amount of programming knowledge required. Meanwhile, automatic programming without user action can only write a few lines of code and implement little functionality. There are relatively few tools available for generating home automation scripting languages. To address this problem, we propose a practical method for generating executable home automation scripts using Chinese texts. Our method includes the following steps: it extracts critical information from the command sentences in Chinese; it uses first-order logic to check the validity of the extracted information; based on the validation, the correct sentences are mapped into the intermediate language scripts, which can interface with different home platforms. We conducted experiments on Home Assistant, converted intermediate scripts to Home Assistant, and collected 600 scenario descriptions. The experimental results show that the method can automatically generate executable scripts for the Home Assistant platform, and the correct rate was 93.66%.
Performances rituales afro-católicas, hermandades y naciones africanas en Buenos Aires a finales del siglo XVIII
Authors: Geler Lea
Published: June 2023

En este artículo se propone realizar un acercamiento a las performances rituales afrocatólicas en la Ciudad de Buenos Aires de finales del siglo xviii. Recurriendo a multiplicidad de fuentes locales se reconstruye una situación general y ponerla en diálogo con el resto de las Indias, con el objetivo de mostrar similitudes y algunas diferencias con lo que sucedía en el sur de Brasil. El artículo avanza asimismo en el estudio de las naciones africanas, proponiendo que una de sus características más importantes era la elusividad. Esta permitía conservar espacios de negritud donde las performances afrocatólicas eran protagonistas.
Fluorescent imaging of synaptic glutamate transients in defined neuronal circuits
Authors: Liang Ruqiang , Sun Junqing , Natan Ryan Gregory , Lyu Boyu , Yu Guoqiang , Jin Yihan , Cheng Hwai-Jong , Zito Karen , Ji Na , Tian Lin
Published: June 2023

A splittable genetically encoded intensimetric fluorescent sensor for glutamate is engineered. It can reconstitute across synaptic clefts and report glutamate transients when the nonfluorescent halves are targeted to pre- and post-synaptic neurons in a circuit.
In Vivo Metabolic Imaging Reveals Mitochondrial Membrane Potential Reprogramming During Residual Disease Following Chemotherapy
Authors: Sunassee Enakshi D. , Crouch Brian , Madonna Megan , Palmer Gregory , Ramanujam Nirmala
Published: June 2023

We performed intravital fluorescent microscopy in preclinical models of disease regression in Triple Negative Breast Cancer to compare dynamic, long-term in vivo changes across three major metabolic axes in chemotherapy-resistant and chemotherapy-sensitive tumors.
The economic value of personal protective equipment for healthcare workers
Authors: Bolas Theodore , Werner Kalin , Alkenbrack Sarah , Uribe Manuela Villar , Wang Mengxiao , Risko Nicholas
Published: June 2023

In this paper, we examine the cost effectiveness of investment in personal protective equipment (PPE) for protecting health care workers (HCWs) against two infectious diseases: Ebola virus and methicillin-resistant Staphylococcus aureus (MRSA). This builds on similar work published for COVID-19 in 2020. We developed two separate decision-analytic models using a payer perspective to compare the costs and effects of multiple PPE use scenarios for protection of HCW against Ebola and MRSA. Bayesian multivariate sensitivity analyses were used to consider the uncertainty surrounding all key parameters for both diseases. We estimate the cost to provide adequate PPE for a HCW encounter with an Ebola patient is $13.04, which is associated with a 97% risk reduction in infections. The mean incremental cost-effectiveness ratio (ICER) is $3.98 per disability-adjusted life year (DALY) averted. Because of lowered infection and disability rates, this investment is estimated to save $132.27 in averted health systems costs, a financial ROI of 1,014%. For MRSA, the cost of adequate PPE for one HCW encounter is $0.88, which is associated with a 53% risk reduction in infections. The mean ICER is $362.14 per DALY averted. This investment is estimated to save $20.18 in averted health systems costs, a financial ROI of 2,294%. In terms of total health savings per death averted, investing in adequate PPE is the dominant strategy for Ebola and MRSA, suggesting that it is both more costly and less clinically optimal to not fully invest in PPE for these diseases. There are many compelling reasons to invest in PPE to protect HCWs. This analysis examines the economic case, building on previous evidence that protecting HCWs with PPE is cost-effective for COVD-19. Ebola and MRSA scenarios were selected to allow assessment of both endemic and epidemic infectious diseases. While PPE is cost-effective for both conditions, compared to our analysis for COVID-19, PPE is relatively more cost-effective for Ebola and relatively less so for MRSA. Further research is needed to assess shortfalls in the PPE supply chain identified during the COVID-19 pandemic to ensure an efficient and resilient supply in the face of future pandemics.
Divergent RNA viruses infecting sea lice, major ectoparasites of fish
Authors: Chang Tianyi , Hunt Brian P. V. , Hirai Junya , Suttle Curtis A.
Published: June 2023

Sea lice, the major ectoparasites of fish, have significant economic impacts on wild and farmed finfish, and have been implicated in the decline of wild salmon populations. As blood-feeding arthropods, sea lice may also be reservoirs for viruses infecting fish. However, except for two groups of negative-strand RNA viruses within the order Mononegavirales, nothing is known about viruses of sea lice. Here, we used transcriptomic data from three key species of sea lice (Lepeophtheirus salmonis, Caligus clemensi, and Caligus rogercresseyi) to identify 32 previously unknown RNA viruses. The viruses encompassed all the existing phyla of RNA viruses, with many placed in deeply branching lineages that likely represent new families and genera. Importantly, the presence of canonical virus-derived small interfering RNAs (viRNAs) indicates that most of these viruses infect sea lice, even though in some cases their closest classified relatives are only known to infect plants or fungi. We also identified both viRNAs and PIWI-interacting RNAs (piRNAs) from sequences of a bunya-like and two qin-like viruses in C. rogercresseyi. Our analyses showed that most of the viruses found in C. rogercresseyi occurred in multiple life stages, spanning from planktonic to parasitic stages. Phylogenetic analysis revealed that many of the viruses infecting sea lice were closely related to those that infect a wide array of eukaryotes with which arthropods associate, including fungi and parasitic tapeworms, implying that over evolutionary time there has been cross-phylum and cross-kingdom switching of viruses between arthropods and other eukaryotes. Overall, this study greatly expands our view of virus diversity in crustaceans, identifies viruses that infect and replicate in sea lice, and provides evidence that over evolutionary time, viruses have switched between arthropods and eukaryotic hosts in other phyla and kingdoms.
The occurrence and pathogenicity of fungi associated with Orthotomicus erosus on Pinus brutia in the Southern Marmara, Türkiye
Authors: Acer Sabiha , Arslangündoğdu Zeynel , Lehtijärvi Asko
Published: June 2023

Fungal pathogens associated with bark beetles constitute one of the most significant problems to forest health. The Turkish pine (Pinus brutia Ten.) is a native species in the forests of Türkiye and occurs in the Mediterranean-type climate. The Southern Marmara is a natural occurrence area of Turkish pine in the Marmara Region. In the present study, trap logs were set up in pure Pinus brutia forests to investigate fungi associated with Orthotomicus erosus (Wollaston) (Mediterranean pine beetle) throughout Southern Marmara. Orthotomicus erosus adults, larvae, and their galleries were sampled and individually cultured on a 1% CSMA (cycloheximide–streptomycin malt agar) medium. Three ophiostomatoid fungi were identified using morphological characteristics and molecular genetic analyses: Ceratocystis (syn. Ophiostoma) ips (Rumbold) C. Moreau, Graphilbum sp. H.P. Upadhyay & W.B. Kendr., and Leptographium wingfieldii M. Morelet. All three species were new in records of the fungal flora of Türkiye. The most dominant of these species, Ceratocystis ips was isolated 69%. Unexpectedly, L. wingfieldii had a high-frequency association with O. erosus (27%). The pathogenicity tests showed that all three species could cause lesions on branches of Turkish pine but were non-pathogenic or weak pathogenic.
Intelligent manufacturing with machine learning: A perspective of European home goods industry
Authors: Liu Ngoc Min-hau , Ngo Phaoun Phom
Published: June 2023

With all the enhancement of Internet of Things, and cloud computing solutions, the volume of info from manufacturing techniques is growing fast. With sizable production specifics, achievements beyond expectations are made towards the product design, manufacturing, and also prevent process. Big data analytics were a main know-how to motivate smart manufacturing methods. To have the ability to totally report BDA for intelligent manufacturing systems, this specific paper offers a considerable review of associated topics, like for example the thought of big data, product driven and info driven methodologies. The framework, development, key technologies, along with programs of BDA for intelligent manufacturing methods, are discussed. The challenges and opportunities for potential investigation are highlighted. By way of this particular work, it is hoped to ignite brand new ideas in the power to observe the BDA for wise manufacturing techniques.
Analytics and innovation management: Does big data play any role?
Authors: Christenson Arthur Paul
Published: June 2023

This particular analysis explores the connection between ﬁrms' application of data analytics (specifically it's attributes) together with the revolutionary functionality of company. The other goal is assessing whether big amount of information is always better to get business innovation. The study collected information via questionnaire survey from control staffs of 250 businesses in both developed and developing economies. Statistical tools like Multiple regression methods and t-test were used to analyse the information. The study found suggestive evidence demonstrating that data analytics is a relevant determinant of a ﬁrm getting innovator and bring innovative services and products on the industry. The study even discovered that big volume of information isn't always better info to drive innovation. The results imply that firms are required to use big data analytics to remain imaginative and also have a competitive advantage. Unlike previous studies which approached large details as whole, this particular study addresses different ingredients of big data like variety, velocity, volume, and the individual impacts of theirs on innovation of organizations across the evolved economies.
How business value can be increased with analytics in the financial services industry
Authors: Singarimbum Buana Lintang
Published: June 2023

Background/ Objectives: Big Data is a tremendously large data set that has been analyzed, managed, managed and validated through a regular info management application. Banks are of all financial services industries, that handle overwhelming quantities of transaction info managed, scrutinized, in addition to employed for the gain of banks and definitely the customers. Thus, this specific analysis paper examined how BDA is handled in Malay/Indian/Indonesian manufacturing banks. The elements which have a larger impact on banks in handling large data were analyzed, in addition to how analytics generates worth for the business. Method/Statistical Analysis: Secondary data was collected from several sources, such as articles, journals and websites. The elements including great data management, consumer segmentation, risk management, fraud detection, in addition to business value of banking industries are studied. A conceptual framework was produced to spotlight the components that have a much better impact on big data management in the banking business. Findings: From the analysis, it's examined that big data analytics has pushed a noticeable change in the business worth of banks, as well as the components that influence the organization. Application/Improvements: Banks must revamp their software architecture for dealing with key information, and stick to the brand new technologies which boost the internet business worth of the company.
Physical Internet towards sustainable supply chain: The significance of digital interoperability
Authors: Ha Hien Minh , Tran Thi Phuong Thuy
Published: June 2023

The purpose of this study is to discover physical internet attributes for satisfying economic, social, and environmental benefits, and frame the hierarchical interrelationships of these attributes. The fuzzy Delphi method is used to define necessary criteria; fuzzy Decision-Making Trial and Evaluation Laboratory is adopted to identify the cause-and-effect relationships based on the experts’ viewpoints. Finding - The result also presents the most important criteria having causal effects on others including privacy preservation approaches, system of logistics network interconnectivity, distributed data storage, real-time locating system, and distributed multi-segment intermodal transport, from which recommend practical implications for the decision-making process. This study suggests both theoretical and managerial implications for improving the physical internet towards sustainable supply chain as physical internet has been perceived as a novel logistics model towards sustainability and a key solution for the current paradigms to overcome sustainable issues. This study contributes to the literature by pointing out the causal aspects for physical internet implementation, which are digital interoperability of supply chain, and shared warehouse and transportation networks.
Consumer retail industry and profitability: The role of analytics
Authors: Rogermann Kristina Candance , Shahtelab Abdel Al
Published: June 2023

As the retail industry gets extensively competitive, the ability to optimize business processes while gratifying customer expectations has never been more essential. Consequently, managing and channelizing info to work to client delight & generate whole revenue is crucial to survive prosperously. In the circumstance of big show players globally and in America, info or perhaps rather big data analytics is now used for every phase of the show progression, tracking emerging items which are common, forecasting potential sales and demand through predictive simulation, optimizing product placements and offers by customer heat mapping, and several others. Alongside this specific, determining the customers are extremely prone to be sharp on certain merchandise sorts based on their prior actions, working out the easiest technique to target them through certain marketing initiatives, and finally working out what to advertise them following will be the point that forms the middle of data analytics. This particular statement will be the product of a descriptive exploration of yesteryear, present and future of the retail industry, and the application of business analytics in shaping suitable marketing methods.
Bücher als bestenfalls widerwillige Verbündete
Authors: Suzuki Nicole
Published: June 2023

Nicole Suzuki geht in diesem Beitrag auf die Verstrickungen der Geschichte des Buches als Medium, wie wir es heute kennen, mit Herrschafts- und Machtstrukturen sowie die traditionell eurozentrische Ausrichtung des literarischen Kanons ein. Ihr Beitrag ist von postkolonialen Denker*innen inspiriert, die betonen, dass wir Machtverhältnisse und Wissensformen aktiv hinterfragen müssen, da diese in unsere Gewohnheiten und unser Handeln eingeschrieben sind. Dementsprechend stellt sie einige Ansätze aus ihrer künstlerischen Forschung vor, die auf ein Verlernen von Büchern gerichtet sind sowie darauf, sich des Double Bind auch im Bereich der literarischen Bildung bewusst zu werden und sich in ihm bewegen zu lernen.
Räumlichkeit und interreligiöse Begegnung
Authors: Kalender Mehmet T.
Published: June 2023

Interreligiöse Begegnungen sind nicht nur durch die beteiligten Personen und Traditionen geprägt, sondern auch durch den spezifischen Raum, in dem sie stattfinden. In Form dichter Beschreibungen untersucht Mehmet T. Kalender in vier interreligiösen Veranstaltungsreihen die Auswirkungen der jeweiligen Austragungsorte auf das Geschehen. Daraus entwickelt er eine vierstufige Systematik zur Beschreibung und Analyse der »Räumlichkeit«, d.h. der Wechselwirkung von Raum und Handeln in interreligiösen Veranstaltungen, die auch jenseits des religiösen Gegenstands anschlussfähig ist.
Nichts anderes als Selbstoptimierung?
Authors: Fiedel Lotta
Published: June 2023

Nur wer sein eigenes Leben in die Hand nimmt, kann erfolgreich und glücklich sein - so das neoliberale Versprechen, das sich in therapeutischen Subjektentwürfen widerspiegelt. Zugleich setzt Psychotherapie an, wo dieses Versprechen brüchig wird. Wie werden die Brüche des neoliberalen Subjektentwurfs in der Psychotherapie bearbeitet? Und was bedeutet das für die gesellschaftliche Rolle von Psychotherapie? Auf der Basis ethnografischer Beobachtungen geht Lotta Fiedel der Ambivalenz von Psychotherapie auf den Grund. Dabei erschließt sie Psychotherapie aus praxeologisch-poststrukturalistischer Perspektive und eröffnet einen überraschenden Blick auf die Materialität therapeutischer Praxis.