bluuebunny/crossref_metadata_2025 huggingface dataset:
Sensing and monitoring in tunnels testing and monitoring methods for the assessment of tunnels
Authors: Strauss Alfred , Bien Jan , Neuner Hans , Harmening Corinna , Seywald Christian , Österreicher Michael , Voit Klaus , Pistone Elisabetta , Spyridis Panagiotis , Bergmeister Konrad
Published: March 2020

The paper presents a review of testing methods and a classification of strategies and tools in terms of technologies and techniques applied to the monitoring of tunnels. In particular, the topic is contextualized through a brief introduction in Chapter 1, followed by defect taxonomy and degradation mechanisms in Chapters 2 and 3, respectively. Chapters 4 and 5 are related to monitoring strategies and technologies. The former consists of purpose‐based categorization of monitoring policies, while the latter consists of classification of monitoring methods including nondestructive and semidestructive techniques as well as of classification of various types of sensors also based on the physical or chemical quantity measured. General rules of implementation and operation of tunnel monitoring systems are presented taking into account international expert knowledge as well as contemporary practical experience in Austria. Considered issues are related to the fib Model Code 2020 (MC2020) focused on evaluation of structural performance assisted by monitoring and testing. Chapter 6 presents challenges related to the monitoring implementation and operation. Chapter 7 discusses about monitoring characteristics in new tunnel, including data acquisition‐transmission and specific monitoring techniques. Chapter 8 instead treats a particular topic related to considerations related to monitoring characteristics of existing tunnel under investigation. Concluding remarks and references finally close the paper.
A fresh look at the gravitational-wave signal from cosmological phase transitions
Authors: Alanne Tommi , Hugle Thomas , Platscher Moritz , Schmitz Kai
Published: March 2020

Abstract

Many models of physics beyond the Standard Model predict a strong first-order phase transition (SFOPT) in the early Universe that leads to observable gravitational waves (GWs). In this paper, we propose a novel method for presenting and comparing the GW signals that are predicted by different models. Our approach is based on the observation that the GW signal has an approximately model-independent spectral shape. This allows us to represent it solely in terms of a finite number of observables, that is, a set of peak amplitudes and peak frequencies. As an example, we consider the GW signal in the real-scalar-singlet extension of the Standard Model (xSM). We construct the signal region of the xSM in the space of observables and show how it will be probed by future space-borne interferometers. Our analysis results in sensitivity plots that are reminiscent of similar plots that are typically shown for dark-matter direct-detection experiments, but which are novel in the context of GWs from a SFOPT. These plots set the stage for a systematic model comparison, the exploration of underlying model-parameter dependencies, and the construction of distribution functions in the space of observables. In our plots, the experimental sensitivities of future searches for a stochastic GW signal are indicated by peak-integrated sensitivity curves. A detailed discussion of these curves, including fit functions, is contained in a companion paper [1].
High scale validity of the DFSZ axion model with precision
Authors: Oda Satsuki , Shoji Yutaro , Takahashi Dai-suke
Published: March 2020

Abstract

With the assumption of classical scale invariance at the Planck scale, the DFSZ axion model can generate the Higgs mass terms of the appropriate size through technically natural parameters and may be valid up to the Planck scale. We discuss the high scale validity of the Higgs sector, namely the absence of Landau poles and the vacuum stability. The Higgs sector is identical to that of the type-II two Higgs doublet model with a limited number of the Higgs quartic couplings. We utilize the state-of-the-art method to calculate vacuum decay rates and find that they are enhanced at most by 1010 compared with the tree level evaluation. We also discuss the constraints from flavor observables, perturbative unitarity, oblique parameters and collider searches. We find that the high scale validity tightly constrains the parameter region, but there is still a chance to observe at most about 10% deviation of the 125 GeV Higgs couplings to the fermions.
In Europe
Authors: van Dongen Jeroen
Published: March 2020

As the History of Science Society, which is based in America, holds its annual meeting in Utrecht, one of the key academic centers on the European continent, one may surmise that the field has returned home. Yet, this hardly reflects how today’s world of scholarship is constituted: in the historiography of science, “provincializing Europe” has become an important theme, while the field itself, as is the case across the world of academia, is centered around a predominantly American literature. At the same time, ever since historians of science emancipated themselves from the sciences a long time ago, they often have appeared, in the public eye, to question rather than to seek to bolster the authority of the sciences. How has this situation come about, and what does it tell us about the world we live in today? What insight is sought and what public benefit is gained by the historical study of science? As we try to answer these questions, we will follow a number of key mid-twentieth-century historians—Eduard Dijksterhuis, Thomas Kuhn, and Martin Klein—in their Atlantic crossings. Their answers to debates on the constitution of the early modern scientific revolution or the novelty of the work of Max Planck will illustrate how notions of “center” and “periphery” have shifted—and what that may tell us about being “in Europe” today.
HIV-Präexpositionsprophylaxe-Versorgung in intersektoraler Zusammenarbeit
Authors: Ahaus Patrick , Potthoff Anja , Kayser Arne , Wach Janet , Brockmeyer Norbert H. , Skaletz-Rorowski Adriane
Published: March 2020

Hintergrund

Zur HIV(„human immunodeficiency virus“)-Präexpositionsprophylaxe (PrEP) wird am WIR – Walk In Ruhr – Zentrum für Sexuelle Gesundheit und Medizin ein innovatives Modellprojekt zur intersektoralen PrEP-Versorgung durchgeführt.

Forschungsziele

Die vorliegende Studie beschreibt, wer mit der PrEP versorgt wurde und wie sich im Verlauf der PrEP-Einnahme das sexuelle Risikoverhalten änderte sowie welche sexuell übertragbaren Infektionen (STI) und unerwünschte Arzneimittelwirkungen auftraten.

Methoden

In die Studie wurden bisher N = 139 Probanden eingeschlossen, die zwischen 10/2017 und 12/2018 mit einer PrEP begonnen haben. Alle PrEP-Nutzer erhielten Fragebögen, zudem wurden Nebenwirkungen, HIV und andere STI mittels klinischer Laborwerte über einen Zeitraum von 13 Monaten erfasst.

Ergebnisse

Die PrEP-Nutzer hatten ein durchschnittliches Alter von 38 Jahren, waren zu 98,6 % Männer, die Sex mit Männern (MSM) hatten, und zeichneten sich durch einen hohen Bildungsstatus und geringe Arbeitslosigkeit aus. Die durchschnittliche Partneranzahl pro Proband innerhalb der letzten 6 Monate stieg im Verlauf signifikant an, während die Kondomnutzung signifikant zurückging. Innerhalb der ersten 4 Monate nach PrEP-Beginn traten 44 STI bei 34 Patienten auf. Es wurde keine HIV-Infektion festgestellt. In den ersten 4 Wochen nach PrEP-Beginn zeigten sich bei 38,8 % der Probanden unerwünschte Arzneimittelwirkungen, hauptsächlich Symptome des Magen-Darm-Trakts.

Schlussfolgerung

Die PrEP-Nutzer hatten einen guten Bildungsstatus und einen festen Arbeitsplatz bzw. eine Ausbildungsstelle. Das sexuelle Risikoverhalten nahm im Verlauf zu, verbunden mit einem gehäuften Auftreten von STI. Unerwünschte Arzneimittelwirkungen zeigten sich insbesondere zu Anfang der PrEP-Einnahme.
Chromite chemistry of a massive chromitite seam in the northern limb of the Bushveld Igneous Complex, South Africa: correlation with the UG-2 in the eastern and western limbs and evidence of variable assimilation of footwall rocks
Authors: Langa Malose M. , Jugo Pedro J. , Leybourne Matthew I. , Grobler Danie F. , Adetunji Jacob , Skogby Henrik
Published: March 2020

The Bushveld Igneous Complex (BIC) is known for its laterally extensive platinum group element–bearing layers, the most famous being the Merensky Reef and the UG-2 chromitite in the eastern and western limbs of the complex. In the northern limb, the Platreef mineralization and a thick chromitite seam below it (referred to as the “UG-2 equivalent” or UG-2E) have been proposed to be the stratigraphic equivalents of the Merensky Reef and the UG-2, respectively. In this study, we compare a suite of UG-2E samples from the Turfspruit project with a UG-2 reference suite from the western limb using petrography, electron probe microanalysis, laser ablation-inductively coupled plasma-mass spectrometry, and Mössbauer spectroscopy. The results show that (a) in Mg# vs. Cr# diagrams, UG-2E chromites have a distinct compositional field; however, when samples of similar chromite modal abundance (≥ 80%) are used, the UG-2E chromites overlap the field that characterizes UG-2 chromites; (b) the UG-2E is more variable in chromite modal abundance than the UG-2; and (c) variations in Mg# and Fe3+/ΣFe in the UG-2E indicate contamination of the magma by metasedimentary rocks of the Duitschland Formation (Transvaal Supergroup) during emplacement, followed by partial re-equilibration of chromite grains with a trapped melt. Thus, we conclude that for chromite modes higher than 80%, the chromite composition retains enough information to allow correlation and that the UG-2E in the northern limb is very likely the UG-2 chromitite.
A multiple reaction monitoring method for determining peanut (Arachis hypogea) allergens in serum using quadrupole and time-of-flight mass spectrometry
Authors: Hands Charlotte M. , Sayers Rebekah L. , Nitride Chiara , Gethings Lee A. , Mills E. N. Clare
Published: March 2020

Peanut is a major cause of severe IgE-mediated food allergic reactions, which can be exacerbated by factors, such as exercise, that may increase allergen uptake into the circulation. Enzyme-linked immunosorbent assays (ELISAs) have been used to determine allergen uptake into serum, but there are concerns over their specificity and a confirmatory method is required. Mass spectrometry (MS) methods have the potential to provide rigorous alternatives for allergen determination. A suite of peptide targets representing the major clinically relevant peanut allergens previously applied in food analysis were used to develop a targeted multiple reaction monitoring (MRM) method for determination of peanut in serum. Depletion of serum using affinity chromatography was found to be essential to allow detection of the peptide targets. A comparison of triple quadrupole and Q-TOF methods showed that one Ara h 2 peptide was only detected by the Q-TOF, the other peptide targets giving similar assay sensitivities with both MS platforms, although transitions for all the peptides were detected more consistently with the Q-TOF. The Q-TOF MRM assay detected peanut from spiked serum more effectively than the triple quadrupole assay, with Ara h 3 being detected down to 3 mg total peanut protein/L of serum, comparable with an Ara h 3–specific ELISA. The poor recoveries observed for both methods are likely due to loss of peanut immune complexes during the serum depletion process. Nevertheless, the Q-TOF MRM method has much promise to confirm the uptake of peanut proteins in serum samples providing immune complexes can be disrupted effectively prior to depletion.
Extracellular phosphoesterases of invertebrate origin: underrated actors in phosphorus recycling?
Authors: Böök Imke Maiken , Saborowski Reinhard
Published: March 2020

Extracellular enzymes contribute substantially to the remineralisation of organic matter in aquatic systems. Marine invertebrates release endogenous enzymes through activities such as sloppy feeding or egestion, but the significance of such processes is widely unexplored. We compared functional key properties such as activity, stability, and apparent molecular masses of extracellular phosphatases from faeces of the marine crustaceansIdotea balthica,Palaemon varians, andHomarus gammaruswith those of their digestive organs. A fluorescent substrate was used to examine enzyme activity qualitatively on agarose plates and quantitatively in microplate assays. Apparent molecular masses and enzyme stability were examined by native substrate gel electrophoresis (NSGE). Active extracellular phosphatase were present in the faeces of all tested species. NSGE activity band patterns were similar in digestive tissue extracts and faeces extracts. The initial enzyme activity retained for about 2 days, but thereafter rapidly decreased. Activity band patterns of digestive organs and faeces ofI. balthicaremained consistent for up to 72 h. Antibiotic treatment did not reduce phosphatase activity in the faeces ofI. balthicaandH. gammarusbut in the faecesP. varians. Because of the comparatively high activities in the faeces, the electrophoretic similarity between faeces and digestive organs, and the limited durability of the enzymes in faeces extracts, we conclude that the studied crustaceans release predominantly endogenous, rather than bacterial phosphatases through faeces. These can substantially contribute to the pool of active extracellular phosphatases and the recycling of phosphorus in aquatic systems. The wider physiological and ecological context is discussed.
Angiotensin-converting enzyme inhibitor treatment early after myocardial infarction attenuates acute cardiac and neuroinflammation without effect on chronic neuroinflammation
Authors: Borchert Tobias , Hess Annika , Lukačević Mario , Ross Tobias L. , Bengel Frank M. , Thackeray James T.
Published: March 2020

Purpose

Myocardial infarction (MI) triggers a local inflammatory response which orchestrates cardiac repair and contributes to concurrent neuroinflammation. Angiotensin-converting enzyme (ACE) inhibitor therapy not only attenuates cardiac remodeling by interfering with the neurohumoral system, but also influences acute leukocyte mobilization from hematopoietic reservoirs. Here, we seek to dissect the anti-inflammatory and anti-remodeling contributions of ACE inhibitors to the benefit of heart and brain outcomes after MI.

Methods

C57BL/6 mice underwent permanent coronary artery ligation (n = 41) or sham surgery (n = 9). Subgroups received ACE inhibitor enalapril (20 mg/kg, oral) either early (anti-inflammatory strategy; 10 days treatment beginning 3 days prior to surgery; n = 9) or delayed (anti-remodeling; continuous from 7 days post-MI; n = 16), or no therapy (n = 16). Cardiac and neuroinflammation were serially investigated using whole-body macrophage- and microglia-targeted translocator protein (TSPO) PET at 3 days, 7 days, and 8 weeks. In vivo PET signal was validated by autoradiography and histopathology.

Results

Myocardial infarction evoked higher TSPO signal in the infarct region at 3 days and 7 days compared with sham (p < 0.001), with concurrent elevation in brain TSPO signal (+ 18%, p = 0.005). At 8 weeks after MI, remote myocardium TSPO signal was increased, consistent with mitochondrial stress, and corresponding to recurrent neuroinflammation. Early enalapril treatment lowered the acute TSPO signal in the heart and brain by 55% (p < 0.001) and 14% (p = 0.045), respectively. The acute infarct signal predicted late functional outcome (r = 0.418, p = 0.038). Delayed enalapril treatment reduced chronic myocardial TSPO signal, consistent with alleviated mitochondrial stress. Early enalapril therapy tended to lower TSPO signal in the failing myocardium at 8 weeks after MI (p = 0.090) without an effect on chronic neuroinflammation.

Conclusions

Whole-body TSPO PET identifies myocardial macrophage infiltration and neuroinflammation after MI, and altered cardiomyocyte mitochondrial density in chronic heart failure. Improved chronic cardiac outcome by enalapril treatment derives partially from acute anti-inflammatory activity with complementary benefits in later stages. Whereas early ACE inhibitor therapy lowers acute neuroinflammation, chronic alleviation is not achieved by early or delayed ACE inhibitor therapy, suggesting a more complex mechanism underlying recurrent neuroinflammation in ischemic heart failure.
Evaluation of improved attenuation correction in whole-body PET/MR on patients with bone metastasis using various radiotracers
Authors: Grafe Hong , Lindemann Maike E. , Ruhlmann Verena , Oehmigen Mark , Hirmas Nader , Umutlu Lale , Herrmann Ken , Quick Harald H.
Published: March 2020

Purpose

This study evaluates the quantitative effect of improved MR-based attenuation correction (AC), including bone segmentation and the HUGE method for truncation correction in PET/MR whole-body hybrid imaging specifically of oncologic patients with bone metastasis and using various radiotracers.

Methods

Twenty-three patients that underwent altogether 28 whole-body PET/MR examinations with findings of bone metastasis were included in this study. Different radiotracers (18F-FDG, 68Ga-PSMA, 68Ga-DOTATOC, 124I–MIBG) were injected according to appropriate clinical indications. Each of the 28 whole-body PET datasets was reconstructed three times using AC with (1) standard four-compartment μ-maps (background air, lung, muscle, and soft tissue), (2) five-compartment μ-maps (adding bone), and (3) six-compartment μ-maps (adding bone and HUGE truncation correction). The SUVmax of each detected bone lesion was measured in each reconstruction to evaluate the quantitative impact of improved MR-based AC. Relative difference images between four- and six-compartment μ-maps were calculated. MR-based HUGE truncation correction was compared with the PET-based MLAA truncation correction method in all patients.

Results

Overall, 69 bone lesions were detected and evaluated. The mean increase in relative difference over all 69 lesions in SUVmax was 5.4 ± 6.4% when comparing the improved six-compartment AC with the standard four-compartment AC. Maximal relative difference of 28.4% was measured in one lesion. Truncation correction with HUGE worked robust and resulted in realistic body contouring in all 28 exams and for all 4 different radiotracers. Truncation correction with MLAA revealed overestimations of arm tissue volume in all PET/MR exams with 18F-FDG radiotracer and failed in all other exams with radiotracers 68Ga-PSMA, 68Ga-DOTATOC, and 124I- MIBG due to limitations in body contour detection.

Conclusion

Improved MR-based AC, including bone segmentation and HUGE truncation correction in whole-body PET/MR on patients with bone lesions and using various radiotracers, is important to ensure best possible diagnostic image quality and accurate PET quantification. The HUGE method for truncation correction based on MR worked robust and results in realistic body contouring, independent of the radiotracers used.
Malignant Insulinoma: A Rare Form of Neuroendocrine Tumor
Authors: Sada Alaa , Glasgow Amy E. , Vella Adrian , Thompson Geoffrey B. , McKenzie Travis J. , Habermann Elizabeth B.
Published: March 2020

Introduction

Due to the rarity of malignant insulinoma, a lack of the literature describing factors affecting outcomes exists. Our aim was to review malignant insulinoma incidence, characteristics and survival trends.

Methods

We identified all patients with malignant insulinoma in the SEER registries from 1973 to 2015. Incidence, neoplasm characteristics and factors affecting cancer‐specific survival (CSS) were described.

Results

A total of 121 patients were identified. The crude annual overall incidence was low (range 0.0–0.27 cases per million person years). The largest proportion had localized disease (40%), while 16% had regional disease, 39% distant metastatic disease, and stage was unreported in 5%. Most neoplasms were in the body/tail of the pancreas, followed by the head of the pancreas. Grade was reported in 40% of patients; only a single patient reported as having grade IV with the remainder all grades I/II. Surgical resection was performed in 64% of patients. Within surgical patients, the median primary neoplasm size was 1.8 cm. Regional lymph nodes were examined in 57.1% of surgical patients, while 34% of examined nodes were positive. The median CSS was 183 months. On multivariable analysis, surgical resection, male sex and absence of metastatic disease were associated with superior survival.

Conclusion

While the greatest proportion of patients with malignant insulinoma present with localized disease, regional lymph node involvement was found in 34% of whose nodes were tested. Further studies are needed to assess the role of lymph node dissection in improving survival and preventing recurrence given the observed frequency of lymph node involvement.
Predictive performance of the mHAP-II score in a real-life western cohort with hepatocellular carcinoma following trans-arterial chemoembolisation with drug-eluting beads (DEB-TACE)
Authors: Peisen Felix , Maurer Michael , Grosse Ulrich , Nikolaou Konstantin , Syha Roland , Ketelsen Dominik , Artzner Christoph , Bitzer Michael , Horger Marius , Grözinger Gerd
Published: March 2020

Objectives

To evaluate the predictive performance of the modified hepatoma arterial embolisation prognostic II (mHAP-II) score in a real-life western hepatocellular carcinoma (HCC) cohort treated with drug-eluting bead-TACE and compare the mHAP-II with other scores in this cohort.

Methods

One hundred seventy-nine HCC patients (mean age 77 (± 9) years, 87% male) with one or more drug-eluting bead (DEB)-TACE sessions using 100–300 μm microspheres were retrospectively analysed. Performance analysis of the mHAP-II score was based on Mann-WhitneyUtests, the Kaplan-Meier method, log-rank tests, receiver operating characteristics, Akaike’s information criterion and Cox regression models.

Results

In this population, HCC risk factors were mainly alcohol abuse (31%) and hepatitis C (28%). The median survival of the entire cohort was 29.4 months. mHAP-II classification of the cohort was mHAP-II B (30%), C (41%) and D (23%) respectively. Survival of all subgroups differed significantly from each other (eachp < 0.05). Area under the curve for receiver operating characteristic was 0.60 and Akaike’s information criterion was 21.8 (p = 0.03), indicating a superior performance of mHAP-II score compared with HAP score and BCLC. Tumour number ≥ two (HR 1.54), alpha-fetoprotein > 400 μg/l (HR 1.14), serum albumin < 3.6 g/dl (HR 1.63) and total bilirubin > 0.9 mg/dl (HR 1.58) contributed significantly in Cox proportional hazards regression (eachp < 0.05).

Conclusion

The mHAP-II score can predict survival outcomes of western HCC patients undergoing DEB-TACE and further subdivide this heterogeneous group; however, certain limitations concerning the predictive power of mHAP-II score must be taken into account.

Key Points

• This retrospective study evaluated the predictive performance of the modified hepatoma arterial embolisation prognostic II (mHAP-II) score in a real-life western HCC cohort treated with drug-eluting bead-TACE.

• Survival of all mHAP-II subgroups differed significantly, area under the curve for mHAP-II was 0.60 and Akaike’s information criterion was 21.8.

• The mHAP-II score can predict survival outcomes of western HCC patients undergoing DEB-TACE and further subdivide this heterogeneous group. However, because the study is underpowered, true survival prediction may be more difficult to infer.
The effect of atmospheric pressure on oxygen saturation and dyspnea: the Tromsø study
Authors: Dohmen Lisa M. E. , Spigt Mark , Melbye Hasse
Published: March 2020

A drop in atmospheric pressure, as observed at high altitudes, leads to decreased oxygen saturation. The effect of regular changes in barometric pressure at sea level has never been studied in a general population. A cohort of adults aged 40 years were examined with pulse oximetry at two separate visits, and the local barometric pressure was available from the local weather station. The study aimed at determining the effect of atmospheric pressure on oxygen saturation also called SpO2, as well as on shortness of breath. Based on spirometry, the participants were divided into two groups, with normal and decreased lung function. Decreased lung function was defined as forced expiratory volume in 1 s (FEV1) below lower limit or normal (LLN) or FEV1/FVC (FVC, forced vital capacity) below LLN, with GLI 2012 reference values. The statistical analysis included uni/multivariable linear and logistic regression. A total of 7439 participants of the Tromsø 7 cohort study were included. There was a significant association between barometric pressure and SpO2 < 96%, and we found that a reduction of 166.67 hPa was needed to get a 1% reduction in SpO2. The change in atmospheric pressure was not significantly associated with shortness of breath, also not in subjects with reduced lung function.
Clinical and radiation dose-volume factors related to pneumonitis after treatment with radiation and durvalumab in locally advanced non-small cell lung cancer
Authors: Inoue Hiroto , Ono Akira , Kawabata Takanori , Mamesaya Nobuaki , Kawamura Takahisa , Kobayashi Haruki , Omori Shota , Wakuda Kazushige , Kenmotsu Hirotsugu , Naito Tateaki , Murakami Haruyasu , Yasui Kazuaki , Ogawa Hirofumi , Onoe Tsuyoshi , Endo Masahiro , Harada Hideyuki , Takahashi Toshiaki
Published: March 2020

Introduction Durvalumab has been shown to confer a survival benefit after definitive chemoradiotherapy in the patients with locally advanced non-small cell lung cancer, but no studies have attempted to identify risk factors for pneumonitis after durvalumab therapy. The purpose of this study was to investigate associations between clinical and radiation dose-volume factors, and the severity of pneumonitis. Methods We retrospectively assessed the cases of 30 patients who had been started on durvalumab therapy between July 2018 and February 2019. In this study we evaluated the percentage of lung volume receiving radiation dose in excess of 20 Gy (V20) as radiation dose-volume factor. We compared V20 and some baseline factors between a grade 0 or 1 (Gr 0/1) pneumonitis group and a grade 2 or more (≥Gr 2) pneumonitis group, and we performed a logistic regression analysis to establish the associations between variables and ≥ Gr 2 pneumonitis. Results Pneumonitis had developed in 22 patients (73.3%): Gr 1/2/3–5 in 8 (26.7%)/14 (46.7%) /0 (0%), respectively. The difference in V20 between the Gr 0/1 group and Gr 2 group (median: 20.5% vs. 23.5%, p = 0.505) was not statistically significant, and thus V20 was not a risk factor for Gr 2 pneumonitis (odds ratio: 1.047, p = 0.303). None of the clinical factors, including sex, age, smoking history, presence of baseline pneumonitis, type of radiation therapy, location of lesion and facility, were risk factors. Conclusions Our study suggest that the severity of pneumonitis after durvalumab is unrelated to V20 or any of the clinical factors assessed in this study.
Influence of the hyperfine structure on plutonium in resonant laser-SNMS
Authors: Bosco Hauke , Weiss Martin , Raiwa Manuel , Walther Clemens , Kneip Nina , Wendt Klaus
Published: March 2020

Resonance ionization mass spectrometry is an ultra-sensitive and highly element selective tool for spectroscopy, ionization and detection of atoms and thus enables rare isotope determination. In combination with spatially resolved sputtering of neutrals by an initial ion beam, e.g. within a commercial secondary ion mass spectrometer, an isotope and isobar selective analysis technique with resolution on the micrometer scale for particles and surfaces is realized. Detection of minuscule amounts of specific actinides, e.g. of plutonium, in environmental and technical samples by this ultra-trace analysis technique requires detailed knowledge about the atomic physics of the element. Identification and characterization of the specific resonance ionization scheme applied within the particular geometry of the apparatus in use is needed. An analysis of the dependence of the specifications, specifically regarding the influence of the relative laser beam polarizations is presented here as an aspect, that could have a severe impact on isotope ratio precision and overall efficiency in the resulting ion signal.
Correction to: EGFR signaling augments TLR4 cell surface expression and function in macrophages via regulation of Rab5a activation
Authors: Tang Jing , Zhou Bowei , Scott Melanie J. , Chen Linsong , Lai Dengming , Fan Erica K. , Li Yuehua , Wu Qiang , Billiar Timothy R. , Wilson Mark A. , Wang Ping , Fan Jie
Published: March 2020

In the original publication the bands in Fig. 1J and Fig. 2B were not visible. The correct versions of Fig. 1J and Fig. 2B are provided in this correction.
The Flesh and the Devil: Belief in Religious Evil and Views of Sexual Morality
Authors: Baker Joseph O. , Molle Andrea , Bader Christopher D.
Published: March 2020

We examine an understudied connection between religion and sexuality: beliefs about the reality of supernatural evil (Satan, hell, and demons). After controlling for multiple other aspects of religiosity, beliefs about religious evil remain a strong and consistent predictor of attitudes about issues involving sexuality, including abortion, homosexuality, premarital sex, extramarital sex, and pornography use. Further, the effects of religious service attendance on attitudes about sexuality are contingent upon beliefs about religious evil. Moral condemnation of non-traditional sexuality is significantly higher among regular religious participants who believe strongly in religious evil compared to actively religious people who disbelieve in religious evil, as well as compared to people who do not attend religious services. Beliefs about religious evil are therefore central to understanding the empirical connections between religion and support for conservative, traditional views of sexual morality.
Teaching next-generation sequencing to medical students with a portable sequencing device
Authors: Cervantes Jorge , Perry Cynthia , Wang Min Chih
Published: March 2020

Background There continues to be a disjoint between the emergence of new diagnostic technologies and venues to train new physicians on how to apply them. Next-generation sequencing (NGS) has become a very important tool for a wide range of clinical applications. Technical complexity and cost have been the major obstacles in incorporating these technologies into the classroom.

Goal for innovation We opted to use the MinION, which is a new portable DNA sequencer that can produce data in real-time at a relatively low cost, for a NGS hands-on workshop with medical students.

Steps taken We conducted a pilot NGS hands-on practical module in order to expose an interested group of medical students to this new portable sequencer device. A pre- and post-survey, using a Likert-type scale survey items and open-ended questions, evaluated participant resistance to new diagnostic tools, familiarity with NGS, and likelihood to use a portable sequencer in clinical practice.

Outcomes Prior to participating in our learning workshop, students did not understand how to incorporate NGS into clinical practice, and expressed that cost and prior training/knowledge were among the limiting factors in their likelihood to use NGS as a diagnostic tool. After participating in the module, students’ responses demonstrated a shift in their understanding of the scientific principles and applications of NGS (pre- and post-survey scores p < 0.05).

Reflection The hands-on experience not only helped students become closer to and more comfortable with NGS, but also served as a venue to discuss the science and application
A novel thermo-mechanical coupling approach for thermal fracturing of rocks in the three-dimensional FDEM
Authors: Joulin Clément , Xiang Jiansheng , Latham John-Paul
Published: March 2020

This paper presents a new three-dimensional thermo-mechanical (TM) coupling approach for thermal fracturing of rocks in the finite–discrete element method (FDEM). The linear thermal expansion formula is implemented in the context of FDEM according to the concept of the multiplicative split of the deformation gradient. The presented TM formulation is derived in the geo-mechanical solver, enabling thermal expansion and thermally induced fracturing. This TM approach is validated against analytical solutions of the Cauchy stress, thermal expansion and stress distribution. Additionally, the thermal load on the previously validated configurations is increased and the resulting fracture initiation and propagation are observed. Finally, simulation results of the cracking of a reinforced concrete structure under thermal stress are compared to experimental results. Results are in excellent agreement.
Constraining Design: Applying the Insights of Cognitive Work Analysis to the Design of Novel In-Car Interfaces to Support Eco-Driving
Authors: Allison Craig K. , Stanton Neville A.
Published: March 2020

The design with intent (DwI) toolkit assists designers in creating novel designs and interfaces. DwI, however, is not constrained to any degree, making it impossible to know whether the produced designs adequately account for users’ needs. In contrast, cognitive work analysis (CWA) is a human factors research tool that seeks to map a system and account for users’ needs, yet does not provide clear guidelines for progressing such analysis into workable designs with which users can interact. This paper seeks to present a proof-of-concept investigation to demonstrate that DwI can be suitably constrained and validated by insights gained from CWA. CWA, in turn, benefits by having a suitable toolkit for progressing insights. Two teams of individuals without design backgrounds were able to develop mock-up in-vehicle interfaces aimed at reducing fuel use. The teams were able to use DwI toolkit to articulate the genesis of their ideas, which in turn could be directly linked to system needs identified within CWA.
Mental health research capacity building in sub-Saharan Africa: the African Mental Health Research Initiative
Authors: Chibanda Dixon , Abas Melanie , Musesengwa Rosemary , Merritt Chris , Sorsdahl Katherine , Mangezi Walter , Bandawe Chiwoza , Cowan Frances , Araya Ricardo , Gomo Exnevia , Gibson Lorna , Weiss Helen , Hanlon Charlotte , Lund Crick
Published: March 2020

Mental, neurological and substance use (MNS) disorders are a leading, but neglected, cause of morbidity and mortality in sub-Saharan Africa. The treatment gap for MNS is vast with only 10% of people with MNS disorders in low-income countries accessing evidence-based treatments. Reasons for this include low awareness of the burden of MNS disorders and limited evidence to support development, adaptation and implementation of effective and feasible treatments. The overall goal of the African Mental Health Research Initiative (AMARI) is to build an African-led network of MNS researchers in Ethiopia, Malawi, South Africa and Zimbabwe, who are equipped to lead high quality mental health research programs that meet the needs of their countries, and to establish a sustainable career pipeline for these researchers with an emphasis on integrating MNS research into existing programs such as HIV/AIDS. This paper describes the process leading to the development of AMARI's objectives through a theory of change workshop, successes and challenges that have been faced by the consortium in the last 4 years, and the future role that AMARI could play in further building MNS research capacity by brining on board more institutions from low- and middle-income countries with an emphasis on developing an evidence-based training curriculum and a research-driven care service.
Identification of COVID-19 can be quicker through artificial intelligence framework using a mobile phone–based survey when cities and towns are under quarantine
Authors: Srinivasa Rao Arni S. R. , Vazquez Jose A.
Published: March 2020

We propose the use of a machine learning algorithm to improve possible COVID-19 case identification more quickly using a mobile phone–based web survey. This method could reduce the spread of the virus in susceptible populations under quarantine.
SOCIAL NETWORKS AS A POLITICAL RESOURCE: REVISITING THE KOREAN DEMOCRATIC TRANSITION
Authors: Choi Joon Nak , Hong Ji Yeon
Published: March 2020

In this paper, we study how political parties react to democratic transitions. We find that the structure of legislators’ social networks plays a critical role in shaping their political interactions during the transition period, and consequently, the post-transition party systems that emerge. We focus on the Korean case, where the incumbent authoritarian party merged with one of its pro-democracy opponents to create a powerful and enduring conservative party under democratic rule. Using a novel individual-level dataset on all legislative members during the transition, we find that the merger was facilitated by dense social networks linking members of the merged parties, which increased trust across the parties and reduced the difficulty of a merger. Conversely, we find that the paucity of ties linking pro-democracy parties hindered their long-term cooperation, despite their shared ideologies and policy goals. The study complements existing theories by providing a network-based explanation for the weakly institutionalized political party system that has characterized Korean politics since democratization.
Honey consumption is inversely associated with prediabetes among Chinese adults: results from the Tianjin Chronic Low-Grade Systemic Inflammation and Health (TCLSIH) Cohort Study
Authors: Zhang Shunming , Kumari Shubham , Gu Yeqing , Li Xiaoyue , Meng Ge , Zhang Qing , Liu Li , Wu Hongmei , Wang Yawen , Zhang Tingjing , Wang Xuena , Cao Xingqi , Li Huiping , Liu Yunyun , Wang Xiaohe , Sun Shaomei , Wang Xing , Zhou Ming , Jia Qiyu , Song Kun , Sun Zhong , Niu Kaijun
Published: March 2020

Evidence has suggested that honey intake has a beneficial impact on glycaemic control in patients with type 2 diabetes. Whether these findings apply to adults with prediabetes is yet unclear. The aim of the present study was to examine whether honey intake is associated with a lower prevalence of prediabetes. A cross-sectional study was performed in 18 281 participants (mean age 39·6 (sd 11·1) years; men, 51·5 %). Dietary intake was assessed through a validated 100-item FFQ. Prediabetes was defined according to the American Diabetes Association criteria: impaired fasting glucose, impaired glucose tolerance or raised glycosylated Hb. Multivariable logistic regression models were used to estimate the association between honey consumption and prediabetes. As compared with those who almost never consumed honey, the multivariable OR of prediabetes were 0·94 (95 % CI 0·86, 1·02) for ≤3 times/week, 0·77 (95 % CI 0·63, 0·94) for 4–6 times/week and 0·85 (95 % CI 0·73, 0·99) for ≥1 time/d (Pfor trend < 0·01). These associations did not differ substantially in sensitivity analysis. Higher honey consumption was associated with a decreased prevalence of prediabetes. More large prospective cohort studies are needed to investigate this association.
Application of N-carbamylglutamate in Rex rabbits to reduce body fat deposition and its possible mechanism
Authors: Wang Youming , Xu Qianqian , Shao Qiang , Lang Xinrui , Liu Wenqiang , Zou Xiaoting , Dong Xinyang
Published: March 2020

N-Carbamylglutamate (NCG) has been shown to enhance arginine synthesis and improve growth performance in animals. However, the effect of NCG on body fat deposition remains unknown. This study examined the effects of NCG on body fat deposition and evaluated the potential mechanisms involved. Rex rabbits (3 months old) were assigned to one of four dietary groups and supplemented with NCG at the following different concentrations in a feeding trial that lasted 67 d: 0 (control), 0·04, 0·08, and 0·12 %. NCG supplementation increased serum concentrations of arginine and proline by activating intestinal carbamoylphosphate synthase-І at the posttranscriptional level. Final body weights and growth performance were not affected by dietary NCG levels. However, NCG-treated rabbits had lower perirenal and subcutaneous fat percentages, serum TAG content, and hepatic fatty acid synthase (FAS) activity and increased NO synthase activity and serum levels of NO, growth hormone (GH), and insulin-like growth factor 1 (IGF-1). There were significant positive correlations between TAG content and perirenal fat percentage, as well as FAS activity and perirenal fat percentage, but significant negative correlations between TAG and NO levels, and FAS activity and IGF-1 level in rabbits after NCG treatment. NCG supplementation did not affect hepatic health indicators, except for serum ammonia concentrations, which were decreased in NCG-treated rabbits. Our results suggest that NCG can serve as a dietary supplement to reduce unfavourable fat deposition through inhibiting hepatic lipogenesis in animals since it appears to have no negative effects on growth performance or hepatic health.
Current metabolic perspective on malnutrition in obesity: towards more subgroup-based nutritional approaches?
Authors: Blaak Ellen E.
Published: March 2020

Lifestyle intervention may be effective in reducing type 2 diabetes mellitus incidence and cardiometabolic risk. A more personalised nutritional approach based on an individual or subgroup-based metabolic profile may optimise intervention outcome. Whole body insulin resistance (IR) reflects defective insulin action in tissues such as muscle, liver, adipose tissue, gut and brain, which may precede the development of cardiometabolic diseases. IR may develop in different organs but the severity may vary between organs. Individuals with more pronounced hepatic IR have a distinct plasma metabolome and lipidome profile as compared with individuals with more pronounced muscle IR. Additionally, genes related to extracellular modelling were upregulated in abdominal subcutaneous adipose tissue in individuals with more pronounced hepatic IR, whilst genes related to inflammation as well as systemic low-grade inflammation were upregulated in individuals with primarily muscle IR. There are indications that these distinct IR phenotypes may also respond differentially to dietary macronutrient composition. Besides metabolic phenotype, microbial phenotype may be of importance in personalising the response to diet. In particular fibres or fibre mixtures, leading to a high distal acetate and SCFA production may have more pronounced effects on metabolic health. Notably, individuals with prediabetes may have a reduced response to diet-induced microbiota modulation with respect to host insulin sensitivity and metabolic health outcomes. Overall, we need more research to relate metabolic subphenotypes to intervention outcomes to define more optimal diets for individuals with or predisposed to chronic metabolic diseases.
Social disadvantage, linguistic distance, ethnic minority status and first-episode psychosis: results from the EU-GEI case–control study
Authors: Jongsma Hannah E. , Gayer-Anderson Charlotte , Tarricone Ilaria , Velthorst Eva , van der Ven Els , Quattrone Diego , di Forti Marta ,   EU-GEI WP2 Group, Menezes Paulo Rossi , Del-Ben Christina Marta , Arango Celso , Lasalvia Antonio , Berardi Domenico , La Cascia Caterina , Bobes Julio , Bernardo Miguel , Sanjuán Julio , Santos Jose Luis , Arrojo Manuel , de Haan Lieuwe , Tortelli Andrea , Szöke Andrei , Murray Robin M. , Rutten Bart P. , van Os Jim , Morgan Craig , Jones Peter B. , Kirkbride James B.
Published: March 2020

Background

Ethnic minority groups in Western countries face an increased risk of psychotic disorders. Causes of this long-standing public health inequality remain poorly understood. We investigated whether social disadvantage, linguistic distance and discrimination contributed to these patterns.

Methods

We used case–control data from the EUropean network of national schizophrenia networks studying Gene-Environment Interactions (EU-GEI) study, carried out in 16 centres in six countries. We recruited 1130 cases and 1497 population-based controls. Our main outcome measure was first-episode ICD-10 psychotic disorder (F20–F33), and exposures were ethnicity (white majority, black, mixed, Asian, North-African, white minority and other), generational status, social disadvantage, linguistic distance and discrimination. Age, sex, paternal age, cannabis use, childhood trauma and parental history of psychosis were included as a priori confounders. Exposures and confounders were added sequentially to multivariable logistic models, following multiple imputation for missing data.

Results

Participants from any ethnic minority background had crude excess odds of psychosis [odds ratio (OR) 2.03, 95% confidence interval (CI) 1.69–2.43], which remained after adjustment for confounders (OR 1.61, 95% CI 1.31–1.98). This was progressively attenuated following further adjustment for social disadvantage (OR 1.52, 95% CI 1.22–1.89) and linguistic distance (OR 1.22, 95% CI 0.95–1.57), a pattern mirrored in several specific ethnic groups. Linguistic distance and social disadvantage had stronger effects for first- and later-generation groups, respectively.

Conclusion

Social disadvantage and linguistic distance, two potential markers of sociocultural exclusion, were associated with increased odds of psychotic disorder, and adjusting for these led to equivocal risk between several ethnic minority groups and the white majority.
White matter microstructure predicts foreign language learning in army interpreters
Authors: Mårtensson Johan , Eriksson Johan , Bodammer Nils Christian , Lindgren Magnus , Johansson Mikael , Nyberg Lars , Lövdén Martin
Published: March 2020

Adult foreign language acquisition is challenging, and the degree of success varies among individuals. Anatomical differences in brain structure prior to training can partly explain why some learn more than others. We followed a sample of conscript interpreters undergoing intense language training to study learning-related changes in white-matter microstructure (FA, MD, RD and AD) and associations between differences in brain structure prior to training with acquired language proficiency. No evidence for changes in white matter microstructure relative to a control group was found. Starting values of RD, AD and MD were positively related to final test scores of language proficiency, corroborating earlier findings in the field and highlighting the need for further study of how initial brain structure influences and interacts with learning outcomes.
The role of magnetic field in the formation and evolution of filamentary molecular clouds
Authors: Inutsuka Shu-ichiro
Published: March 2020

Recent observations have emphasized the importance of the formation and evolution of magnetized filamentary molecular clouds in the process of star formation. Theoretical and observational investigations have provided convincing evidence for the formation of molecular cloud cores by the gravitational fragmentation of filamentary molecular clouds. In this review we summarize our current understanding of various processes that are required in describing the filamentary molecular clouds. Especially we can explain a robust formation mechanism of filamentary molecular clouds in a shock compressed layer, which is in analogy to the making of “Sushi.” We also discuss the origin of the mass function of cores.