bluuebunny/crossref_metadata_2025 huggingface dataset:
Two Cases of Cerebrospinal Fluid Rhinorrhea Repair Surgery Using TachoComb
Authors: Bae Ah Young , Kim Sun Hong , Hwang Se Hwan
Published: April 2024

Cerebrospinal fluid (CSF) rhinorrhea is a rare condition characterized by the leakage of CSF through the nose. The diagnosis is established through comprehensive history taking, brain imaging, and nasal endoscopy. Surgical intervention is considered a secondary option for CSF leakage when conservative treatments, including behavioral therapy, pharmacotherapy, or lumbar puncture, fail to elicit a response. In recent years, endoscopic intranasal surgery has been favored over craniotomy for such surgical treatment. When repairing CSF leakage defects via endoscopic intranasal surgery, autologous fat and muscle flaps are commonly employed. However, these grafts may lead to complications, including donor site infection, edema, and wound dehiscence. Therefore, in this article, we would like to introduce two cases of CSF rhinorrhea repair surgery using TachoComb. While previous studies have employed TachoComb as a supplementary material for the repair of CSF leak defects, in the cases we describe, the primary reconstruction of the defect area was achieved using TachoComb, supported by free grafts such as septal bone or turbinate mucosal flap, which were smaller than the size of the CSF leakage defects.
Kesadaran Hukum Lembaga Keuangan Syariah Atas Kewenangan Absolut Pengadilan Agama Dalam Menyelesaikan Sengketa Ekonomi Syariah
Authors: Rosyidi A. Afwan
Published: April 2024

Berdasarkan data dari Pengadilan Agama Malang, kasus ekonomi syariah pada tahun 2012-2021 hanya 17 kasus. Rendahnya kesadaran hukum terhadap kewenangan absolut Pengadilan Agama dapat berpotensi menimbulkan permasalahan seperti kasus yang sama akan terulang kembali atau salah satu pihak tidak menjalankan kewajiban karena tidak memiliki kekuatan hukum (inkrah). Penelitian ini bertujuan untuk menganalisis tingkat kesadaran hukum lembaga ekonomi syariah (BUS, BPRS, IKNB Syariah) atas kewenangan absolut Pengadilan Agama dalam menyelesaikan sengketa ekonomi syariah di Kota Malang. Penelitian ini menggunakan metode penelitian empiris dengan pendekatan yuridis sosiologis. Hasil artikel ini menunjukan beberapa lembaga memiliki pengetahuan dan pemahaman hukum yang baik terhadap kewenangan absolut Pengadilan Agama, sementara yang lain masih perlu peningkatan. Secara umum, lembaga-lembaga tersebut mendukung penyelesaian sengketa ekonomi syariah di Pengadilan Agama. Namun, ada sebagian lembaga yang memilih Basyarnas sebagai alternatif penyelesaian sengketa, alasannya cukup variatif mulai dari nominal sengketa relatif kecil, penyelesaian sengketa lebih sederhana, dan juga waktu penyelesaiannya lebih singkat. Prosedur penyelesaian sengketa ekonomi syariah di semua lembaga hampir sama, dimulai dengan musyawarah, pemberian surat peringatan, sita jaminan atau lelang, dan jika masih terjadi perselisihan, sengketa diajukan ke Pengadilan Agama atau Basyarnas.
Organic carbon distribution between structural and process pools in the gray forest soil of different land use
Authors: Lebedeva T. N. , Sokolov D. A. , Semenov M. V. , Zinyakova N. B. , Udal’tsov S. N. , Semenov V. M.
Published: April 2024

The summarized data on the content of organic carbon (Corg) in the subtypes of gray forest soils occurring on the territory of Russia was presented. It was shown that the humus horizons of virgin light-gray, typical-gray, and dark-gray forest soils contain, on average, 2.16 ± 0.67, 2.42 ± 0.61, and 3.58 ± 0.95% Сorg, respectively, while the plowing layers of arable soils contain 1.36 ± 0.40, 1.71 ± 0.40, and 2.84 ± 0.86%, respectively. Structural (particulate organic matter 0.05–2 mm in size, CPOM, and mineral-associated organic matter <0.05 mm in size, CMAOM) and process (potentially mineralizable organic matter, C0, and microbial biomass, Cmic) pools were isolated in the organic matter of samples from different horizons of gray forest soils (Luvic Retic Greyzemic Phaeozems (Loamic)) under small-leaved forest and barley crop. The CPOM/CMAOM ratio in the upper soil horizons under forest and arable land was 0.60 and 0.26, respectively, and this ratio decreased with depth to 0.05 under both land uses. The sizes of the CMAOM, CPOM, C0, and Cmic pools correlated with each other and depended on the depth of the soil horizon, while the effect of land use on the pool ratios was found only for the surface horizons. The contribution of CPOM and CMAOM to the potentially mineralizable pool of organic matter in gray forest soil was 20–41 and 71–87%, respectively. According to the obtained data, the size of the C0 pool was almost equal to the annual amount of the heterotrophic CO2 emission from the soil. It was emphasized that determining of the sizes and ratios of structural and process soil organic matter pools should be important in the programs of carbon monitoring and recarbonization of agroecosystems.
Halkla İlişkiler Uygulaması Olarak Medya ile İlişkiler: Konya Basını Örneği
Authors: Büyükeken İbrahim , Tarhan Ahmet
Published: April 2024

Son yıllarda kuruluşlar basında daha fazla yer alabilmek gerek yerel ve gerekse de ulusal basında yer bulabilmek için halkla ilişkiler alanından yararlanmaktadır. Kurum ve kuruluşlar için basın bültenleri medya ile ilişkilerde çok önemli rol oynamaktadır. Bu çalışmanın ana teması halkla ilişkiler ve yerel basın ilişkilerini ele almak ve halkla ilişkiler ajansları ve kurum içi halkla ilişkiler birimleri tarafından gönderilen basın bültenlerinin haber olarak değerlendirilme oranını ölçmektir. İçerik analizi ve derinlemesine mülakatın birlikte kullanıldığı bu çalışmada karma yöntem kullanılmıştır. Konya’da yayın yapan yerel gazetelerin yazı işleri müdürleri ile basın bültenleri konusuna derinlemesine mülakat gerçekleştirilmiştir. Bu çerçevede Konya’da yayın yapan Merhaba Gazetesi’ne halkla ilişkiler ajansları, basın danışmanları ve halkla ilişkiler birimleri tarafından basın kuruluşlarına bültenleri ve bunların yayınlanma oranları içerik analizi yöntemi ile incelenmiştir. Basın bültenlerinin gönderilme oranı, günlere göre yayınlanma oranı, yazım formatı, yayınlanmama gerekçeleri gibi konular ele alınmıştır. 14 gün boyunca gönderilen 527 bültenin % 19,7’si haber olarak kullanılırken, % 80,3 ise sayfalarda haber olarak yayınlanmamıştır. Bültenlerin yayınlanmama gerekçeleri arasında gönderilen bültenlerin haber değeri taşımaması, reklam içermesi, geç saatlerde gönderilmesi, yazım hataları, görsel unsurların eksikliği gibi nedenler bulgulanmıştır.
Akışkan Modernitede Anlamı Yakalamak: Post-Truth Üzerine Bir İnceleme
Authors: Aydın Hasan
Published: April 2024

Zygmunt Bauman’ın “akışkan modernite” olarak nitelendirdiği dönem içerisinde, amaçların yokluğu, belirsizlik ve değişimin durmaksızın devam etme ilkesi neticesinde klasik modernitenin katı yapıları işlevsiz kalmıştır; toplumun sürekli değişimi, bireyin anlam verme, düşünme ve eylemlerinde izleyeceği referans noktalarını ortadan kaldırmıştır. Modern yaşamın bu yönde karmaşıklaşması ve yabancılaşmanın artması, geleneksel yaşamın kısıtlı ilişki ve anlamlandırma yapılarını değiştirmiştir. Özellikle yeni medya teknolojileri iletişimin küreselleşmesini sağlayarak farklı kültür ve deneyim alanlarından gelen enformasyon akışını, bireyin algılama kapasitesinin üstüne çıkarmıştır. İletişimin böylesine hızlandığı bir dönemde hakikat, olguların karmaşıklığından kopartılarak içeriğinden arındırılmış ve imaj düzeyinde biçimsel bir olguya dönüştürülmüştür. Bu doğrultuda çalışmanın önemi, post-truth döneminde hakikatin imaj düzeyinde duygu ve inançlara göre dizayn edilmesinin, bireyin sadece medya ve popülist liderler tarafından manipüle edildiğini değil, aynı zamanda bu sürecin etkin bir katılımcısı olduğunu tartışmaya açmaktır. Bu bağlamda çalışmanın amacı, bireyin anlam arayışı çerçevesinde, yaşamı anlamlandıran kesin ve sabit kimlikleri güvende tutmak amacıyla post-truth sürecine nasıl katıldığını incelemektir. Çalışmada teorik olarak bireyin post-truth sürecine etkin katılımı incelenmiş; bireyin kimliğini güvende tutan fakat olguların gerçekliğiyle bağdaşmayan hakikatleri, psikolojik olarak güven sağlamak amacıyla kabul ettiği sonucuna varılmıştır.
Gambaran Tingkat Pengetahuan tentang Kesehatan Reproduksi pada Remaja SMA di Kabupaten Kubu Raya
Authors: Nupus Restu Hayatun , Ligita Mita Titan
Published: April 2024

Indonesian adolescent reproductive health mentions one of the actions of adolescents that often becomes a problem for their reproductive health is that adolescents have friends who have had sexual relations at the age of 15-19 years. Females accounted for 34.7%, and adolescent boys 30.9%. This condition shows that adolescents very highly carry out premarital sex behavior, and this sexual activity puts adolescents at risk of various reproductive health problems. This study aimed to determine the level of knowledge about reproductive health in high school adolescents in Kubu Raya Regency. The method in this study was carried out using a quantitative descriptive research design with a cross-sectional research approach. The sampling using a stratified random sampling technique. The results obtained were the categories of knowledge found in respondents, namely, knowledge level of knowledge amounted to 160 people (74.4%), medium amounted to 45 people (20.9%), and less amounted to 10 people (4.7%). Based on the research results, it was found that women found the level of knowledge by gender to be better than that of men.
Issues of diagnosis of visual gnosis in children with special needs
Authors:   Derzhavin Tambov State University, Markova Olga N. , Yemelyanova Nadezhda V. , Novoselova Victoria A. ,   Derzhavin Tambov State University
Published: April 2024

The issues of diagnosing visual gnosis connected with the ability to recognize and interpret visual stimuli, which is an essential component of general cognitive function, especially sensitive for children with special needs. The purpose of this research is to contribute to the improvement of diagnostic methods for visual gnosis and, as a result, to provide targeted intervention for children with developmental delays experiencing problems with visual perception. In this work, the following methods were used: a specially designed questionnaire for specialists, sheets from a diagnostic album with images of real objects, unfinished images of objects and noisy images; Poppelreiter's test, “Conflicting images”; “Undersized images” (A.F. Anufriev and S.N. Kostromina), as well as the Bourdon–Wiersma test. The study sample consists of 10 specialists (6 psychologists and 4 speech pathologists) and 30 preschool children (5–7 years old) with normotypic development and with special needs. The results of visual gnosis assessment with classical stimulus materials among normotypic children and children with special needs show that a number of stimulus materials are mistakenly interpreted by children and create the illusion of agnosia. To overcome these difficulties, an updated diagnostic stimulus material has been developed, the use of which has shown high effectiveness in assessing visual gnosis in preschool children. The use of updated stimulus material allows the specialist to quickly and accurately diagnose various types of object agnosia, in particular, the agnosia of letters and shapes, optical-spatial, simultaneous and color. As a result with updated stimulus material the specialist has improved accuracy and quality of diagnostic results; the possibility of earlier detection and correction of visual gnosis issues; increased convenience and accessibility of the technique for specialists.
Formation of stage culture among choreography students in professional training at the university
Authors:   Derzhavin Tambov State University, Yurieva Marina N.
Published: April 2024

The transformation trends in the higher education system in modern Russian society are manifested first of all in new targets, criteria and indicators of the quality of education aimed at the formation of general cultural and professional competencies of the future specialist. The process of professional training of choreography students at universities of culture and arts covers a number of pedagogical factors and issues, the most important of which is the formation of a stage culture of creative specialists, which acts as an element not only of personal and professional development, but also as a pedagogical resource, a creative component of educational and social and cultural activities at the university. The concepts of “culture”, “concert and stage activity”, “scenography”, “stage culture” are differentiated. The revealed structural and functional components of the formation of the stage culture of choreography students at universities of culture and arts are educational and organizational, project-oriented, correctional and reflective, which activate and ensure the implementation of this phenomenon in the concert and performing activities of students. We consider the theoretical prerequisites for updating the content of the main educational programs in the bachelor's degree 52.03.01 “Choreographic art”, the development of interaction between structural units of the educational system of the university in order to increase the effectiveness of training young specialists, solving complex and multifaceted artistic and educational tasks.
Dual training in professional teacher education: implementation experience and prospects
Authors:   Kurgan State University, Hazanov Ilya Ya.
Published: April 2024

Abstract. We consider issue of methodological support for dual training in teaching academic disciplines of the professional cycle while training future teachers. We define dual training in teacher education as an organizational and content system of professional and social and cultural interaction of educational institutions, creating conditions for the practice-oriented formation of the personality and professional competencies of future teachers, is given. The experience of introducing dual training in a pedagogical college is analyzed within the framework of professional training in specialties 44.02.02 “Teaching in primary grades” and 44.02.05 “Correctional pedagogy in primary education”. Students' ideas about the role of dual education in professional training have been studied, the most effective forms of interaction between students and practicing teachers have been identified, as well as the main difficulties in the implementation of dual education. The study shows a high level of motivation for future teachers to implement dual education and its promise as a form of organizing the educational process. Using the example of the interdisciplinary course “Theoretical and Methodological Foundations of the Class Teacher’s Activities”, we determine the principles for the development and implementation of dual learning mechanisms, show specific methodological methods for implementing dual learning through a system of practical classes, classroom teaching practice, independent study work, and final certification of students, and the main forms of interaction with school teachers in the educational process.
Evaluative function of emotional and aesthetic component of student's personality
Authors:   Tambov State Musical Pedagogical Institute named after S.V. Rachmaninov, Klimenko Alexandr V.
Published: April 2024

We consider modern approaches to determining the evaluative side of the emotional and aesthetic component in a modern personality. The interrelation of the emotional and aesthetic parts as dynamic and meaningful components is revealed. The defined structure of the emotional and aesthetic component of personality is multilevel, multifaceted and multifunctional. Based on the many components of the emotional and aesthetic component of the personality, a system of criteria for evaluating the attitude of a person to people and business is eventually formed. Emotional and aesthetic development, providing a conscious, sensual perception of the surrounding reality by a person, forms the moral basis of views and beliefs, provides the opportunity for full-fledged productive interaction, cooperation, communication in collective creativity and various life situations. The level of emotional and aesthetic development of a personality is determined by objective socio-pedagogical and subjective psychological and physiological factors. To unite the team and coordinate the dance group, it is desirable to align it to a socially approved one. In most cases, the level of emotional and aesthetic development of a person is subject to correction, which is possible in the process of collective forms of education that contribute to changing the attitude of a person to creativity, the educational process, self-development and professional formation. The highlighted main components of the evaluation function of the emotional and aesthetic component of the personality can be formed during the educational process of students of the choreographic department and contribute to its effectiveness. As the most effective we consider an open discussion, implemented through the use of communicative skills in accordance with the emotional and aesthetic requirements of the culture of communication, as well as collective versatile creativity with the distribution of role functionality.
DOES REVERSE CAUSALITY EXPLAIN THE RELATIONSHIP BETWEEN DIET AND DEPRESSION？—POSSIBLY RELATED TO DIET'S SUBJECTIVE BEHAVIOR
Authors:   School of Public Health, Southeast University, Nanjing, China, Jin Xingyi
Published: April 2024

Depression can result in changes in eating behavior and decrease the quality of eating. It has been shown that maternal depression during pregnancy can result in malnutrition, which can have adverse effects on the pregnancy and the offspring. There is currently no clear association between depression and diet; (2) Methods: Five hundred and forty-nine pregnant women recruited from Danyang Maternal and Child Health Hospital in Jiangsu Province participated in this study and were administered the Intuitive Eating Scale-2(IES-2), Edinburgh Post-natal Depression Scale (EPDS), Pregnancy Stress Scale (PPS), Self-rating Anxiety Scale (SAS), and Dietary Guidelines Adherence Index for Pregnant Women during Pregnancy (CDGCI-PW). The nutritional software collected dietary records for three consecutive days in mid-pregnancy to calculate dietary intake and nutrients that support energy production. The mediation analyses were conducted using SPSS 24.0 macro PROCESS; (3) Results: The relationship between depressive symptoms during pregnancy and diet quality was moderated primarily by two aspects of eating behavior, “Reliance on Hunger and Satiety Cues” (RHS) and “Body-Food Choice Congruence” (BFC). Depressive symptoms (EPDS scores) showed a negative correlation with RHS, BFC, and RHS, and BFC showed a positive correlation with diet quality, yielding a significant specific indirect effect. the multiple mediation model explained 14.7% of the variance in the diet quality; (4) Conclusions: Individual awareness of depression may influence the causal association between nutrition and depression. This study highlights the important role of eating behaviors during pregnancy in the relationship between depressive symptoms (EPDS scores) and diet quality and provides preliminary evidence for feasible ways pregnant women with depressive symptoms can improve diet quality, promote maternal and child health, and reduce depression.
WOMEN AND NATURE: ECOPSYCOCHOLOGICAL FILM READING
Authors:   Arts, Humanities and Social Sciences, University of Limerick, Limerick, Ireland, Derdous Rym
Published: April 2024

Nature-based studies yielded significant results concerning the psychological benefits of nature exposure. As such, ecopsychology is concerned with the relation human beings have with the surrounding environment. Using a multimodal approach comprising textual film analysis and ecopsychology, this work examines natural elements in the films Papicha (2019) and Clair Obscur (2016) and the psychological effects ensuing a nature experience. Papicha (2019) directed by Mounia Meddour tells the story of Nejdma who struggles to achieve her dream as a fashion designer in a demanding society. Likewise, Chenaz and Elmas in Clair Obscur (2016) defy society in their way to regain their independent autonomous selves. Although from two different cinematic traditions, the former Algerian and the latter Turkish, the films provide an audio-visual experience that traces the main characters’ state of mind before and post nature exposure and their journeys towards self-discovery and empowerment. The emphasis on solely female protagonists, in addition to nature, promotes feminist ecopsychological thinking. It provides an opportunity to explore feminist perspectives by highlighting the connection between women and nature portrayed through these female protagonists' experiences. The Emphasis on Female Protagonists in Both Films not only Aligns with Ecopsychology but also Promotes Ecofeminist Thinking.
WHY STAY? SAUDI WOMEN’S ADAPTIONS TO VIOLENCE
Authors:   Professor of Sociology, King Abdulaziz University, Jeddah, Saudi Arabia, Alazab Seham , Almosaed Norah ,   Professor of Sociology, King Abdulaziz University, Jeddah, Saudi Arabia
Published: April 2024

The study investigates the reasons why women continue to live with an abusive husband and examines the relationship between their reasons and a number of variables that support one’s ability to cope with spousal violence. These variables include employment status, educational level, number of children, marriage duration, the social status of the wife's family and the number of violent incidents. A demographic survey and a spousal violence adaption scale were administered to a sample of 114 abused wives. The results revealed that all of the variables and several of the dimensions represented by the violence adaption scale affected the women’s decisions. The impact of these variables was more obvious among nonworking wives and the lesser educated, women with a greater number of children, those who had been married longer, those who senatal families had a low social status, and those who were subjected to violence more frequently. Keywords: adaptation to violence, marital violence, Saudi Arabia, spousal violence, violence against women in Saudi Arabia, why women stay in violent relationships.
THE MANAGEMENT OF COMMERCIAL APARTMENT IN THE PERSPECTIVE OF UNIT OWNERS’ PROSPERITY IN INDONESIA (Case Study in Apartemen Pondok Indah Villa III Jakarta and Apartemen Sejahtera Yogyakarta, Indonesia)
Authors:   Faculty of Law, Universitas Atma Jaya Yogyakarta, Hutapea Maria
Published: April 2024

The purpose of the research is to find out the managemenrt of commercial apartment relating to the prosperity of the unit owners. It uses empirical legal research by examining the operation of management of the apartment by case study at Apartemen Pondok Klub Villa III Jakarta and Apartemen Sejahtera Yogyakarta, in the perpective of the prosperity of the unit owners. The result shows that both apartment management embody the prosperity of the unit owners eventhough with different management and result. In the cases, the Apartemen Pondok Klub Villa III Jakarta is managed by association body of owners, while Apartemen Sejahtera Yogyakarta is managed by a company established by th¬e committee of association body of owners. These different management results different benefit to the unit owners of the apartement.
Vasospasmo Mamilar: Uma Causa Tratável de Mastalgia na Amamentação
Authors: Dias da Mota Vanessa , D’Oliveira Andreia , Marques Gomes Luísa , Alberto Silva Manuel , Oliveira Ana Rita
Published: April 2024

N/a.
Reerupción espontánea de diente primario con traumatismo de tipo luxación intrusiva: seguimiento de un caso
Authors: Serrano Cabana Rina Alexandra , Rivera Canales Rosa Luz , Vega Ganoza Elva Patricia , Perona Miguel de Priego Guido Alberto
Published: April 2024

Los traumatismos en la dentición primaria a menudo requieren un manejo diferente al que se hace en la dentición permanente. Se presenta el caso de una paciente mujer de 18 meses de edad, en aparente buen estado general, sin antecedentes médicos, que acude al servicio de Odontopediatría del Centro Dental Docente de la Universidad Peruana Cayetano Heredia a razón de que «se le ha incrustado un diente al caerse». Luego del examen extraoral, se observa un edema en el labio inferior; e intraoralmente se muestra un desplazamiento apical de la pieza 61. Radiográficamente, se observa que la pieza 61 se encuentra giroversada con desplazamiento apical. Diagnóstico: Luxación intrusiva de la pieza 61 y contusión del labio inferior. Tratamiento: Se realiza lavado con suero fisiológico; se le indica dieta blanda y que use cepillo de cerdas suaves; se mantiene en observación. Controles: Se realizó seguimiento durante siete meses, tiempo en el que se observó la reerupción espontánea del diente afectado. Por tanto, la reerupción espontánea es una opción de tratamiento en dientes primarios intruidos después de un traumatismo.
Business Model for Small-Scale Artisan Tea Family Business
Authors: Budiyoko Budiyoko , Prayoga Adistiar , Rusdah Rusdah , Mehmet Sıtkı İlkay  , Abdulhakim Madiyoh  , Satriana Eka Dewi , Afrianto Whisnu Febry
Published: April 2024

Background: Tea stands as one of Indonesia's primary plantation commodities. The demand for tea in the domestic market is currently experiencing positive growth, reflecting shifts in consumer lifestyles and an increased interest in health products. Among the varieties of processed tea available, artisan tea stands out for its superior quality and distinctive characteristics. CV BMB, a family-owned small-scale enterprise, specializes in the development of various artisan tea products. This startup has received support from the startup incubation program provided by the Start Up-Business Development and Incubation Agency of Universitas Airlangga and the Ministry of Cooperatives and Small and Medium Enterprises of the Republic of Indonesia. Given its niche market and unique business management approach based on familial relationships, this company presents an intriguing case for analyzing its business model.
Objective: This research aims to analyze the business model and competitive strategies of CV BMB, to enable it to compete effectively and sustain growth in a competitive market.
Method: This research was conducted using a phenomenological approach. The analysis of CV BMB's artisan tea business model was carried out using the business model canvas. Subsequently, Porter's Five Forces analysis was conducted to obtain suitable competitive strategies for small-scale family businesses producing artisan tea.
Results: Porter's Five Forces analysis successfully identified competitive elements within the artisan tea market. Additionally, nine elements in the business canvas model have been identified, contributing to the competitive strategy and development of CV BMB as a small-scale family business producing artisan tea. Three alternative strategies for BMB's business development have been outlined: market expansion, product innovation and development, and management enhancement.
Conclusion: The uniqueness of BMB's artisanal tea products, and the market niche that is still open, is an opportunity for future development. As a family business company, the strategy implementation of business model analysis is expected to drive BMB's positive growth.
Keywords: artisan tea; family business; business model canvas.
Research advances in immunotherapy combined with DNA damage response inhibitors for liver cancer therapy
Authors: Yang Chen , Tao Tao , Wu Yijie , Wang Weijie , Liu Song-Bai
Published: April 2024

Cancer immunotherapy utilizes checkpoint inhibitors to amplify the antitumor immune response. The DNA damage repair system plays a crucial role in preserving genome stability, offering therapeutic avenues for tumor treatment by impeding the DNA damage repair pathway. In cancer immunotherapy, checkpoint inhibitors are used to enhance the antitumor immune response. The DNA damage response (DDR) and immune response are inseparably intertwined and have the potential for synergy. Various recent studies have demonstrated that DDR inhibitors (DDRis) can substantially enhance the clinical efficacy of immunotherapy for hepatocellular carcinoma (HCC) by enhancing the immune response of cancer cells. This article primarily describes the immunotherapy of HCC and compiles the research findings and advancements in clinical applications of combined immunotherapy with DDRis. This study provides insight into the application of the DDR pathway in immunotherapy and provides invaluable insights for the clinical advancement of precise and efficacious treatment strategies.
Pengaruh Ukuran Butiran Kapur Pertanian yang Diberikan Berdasarkan Sulfat Larut terhadap Peningkatan pH Tanah Sulfat Masam
Authors: Afiat Ramzy Nurul , Mahbub Muhammad , Mariana Zuraida Titin
Published: April 2024

Acid sulfate soils contain pyrite and when pyrite is oxidized it causes the soil pH to decrease. Application of agricultural lime CaCO3 is needed to raise soil pH. The grain size of lime greatly affects the fast, slow, and persistent increase in soil pH. This research method used a completely randomized design (CRD) with a single factor, namely the grain size of agricultural lime (18-35 mesh, 18-70 mesh, <18 mesh, 35-70 mesh, <35 mesh, <70 mesh). The treatment was repeated 4 times. The dose of lime given is based on the value of the bulk density of the soil and the sulfur of the soil solution. Observation of soil pH was carried out after an incubation period of 4 weeks using glass electrodes with various ratios of soil and water (1:2.5; 1:5; 1:7.5; 1:10). The results showed that the grain size of lime affects the increase in pH of acid sulfate soil in the soil-water ratio measurement method of 1:5 and 1:10, except for the measurement method 1:2.5 and 1:7.5. The smaller the lime size, the greater the increase in pH of acid sulfate soil. The largest increase in soil pH in the soil-water ratio measurement method was 1:10, for each grain size from the largest to the smallest: 18 - 35 mesh, 18 - 70 mesh, <18 mesh, 35 - 70 mesh, <35 mesh and <70 mesh, resulting in soil pH successively: pH 4.52; pH 4.58; pH 4.53; pH 4.60 ; pH 4.63 and pH 4.70.
Populasi Bakteri Penambat N2 Atmosfer pada Tanah Sawah yang Diberikan Herbisida dengan Berbagai Kandungan Bahan Aktif
Authors: Setiawan Hendra , Hadi Abdul , Razie Fakhrur
Published: April 2024

Supporting the increase in agricultural production today cannot be separated from the use of herbicides in land preparation activities. Most of the herbicides applied to plants will eventually fall to the ground, then undergo changes and in a certain time will be absorbed by the clay fraction and organic matter in the soil, which is generally known as herbicide residue. Toxic herbicide residues in the soil can kill soil microbes, which are not actually the target (non-target microorganisms) so that they interfere with the activity of soil microorganisms which in turn can affect the nutrient cycle in the soil.This research was conducted with the aim of knowing the effect of giving herbicides with various types of active ingredients in paddy fields on the viability of N-fixing bacteria and their relationship to soil chemical properties.The research and analysis was carried out from November 2021 to January 2022. The method used in this study was the Completely Randomized Design (CRD) environmental design method with a single factor treatment design, namely the type of herbicide active ingredient. Based on the results of research that has been carried out, it is known that the herbicide Glyphosate can increase the population of atmospheric N2-fixing bacteria in the soil, while the herbicide Paraquat and Methyl Metsulfuron can suppress the population growth of atmospheric N2-fixing bacteria
Analisis Kandungan Hara N, P, dan K pada Perbedaan Lahan yang Ditanami Karet dan Kelapa Sawit
Authors: Hidayanti Nur , Mahbub Muhammad , Haris Abdul
Published: April 2024

The general obstacles in cultivating rubber and oil palm are soil acidity and limited availability of nutrients, especially N, P, and K. These nutrients play an important role in the growth of rubber and oil palm plants. Knowing the nutrient content is necessary to be able to determine the management that needs to be carried out. The objective of this study is to determine differences in the nutrient content of N, P, and K on various lands planted with rubber and oil palm plants. Soil sample analysis was conducted in the laboratory for available N, available P, and available K. To determine differences in land use for the elements N, P and K, data were analyzed using an unpaired two sample t test. The results showed differences in available K and available P levels between the two land types, while no differences were observed in N availability between the two land types. This variation may be caused by differences in land management practices.
THE COLOR CHANGE EFFECT OF THERMOPLASTIC NYLON AFTER IMMERSION IN 30% KELAKAI (Stenochlaena palustris) LEAF EXTRACT
Authors: Putri Vony Oktamillenia , Arifin Rahmad , Dewi Renie Kumala
Published: April 2024

Background: The most commonly used denture cleanser is alkaline peroxide, but this type of denture cleanser can cause color changes of the denture base and is relatively expensive, so alternative denture cleansers from natural ingredients are needed. Kelakai leaves have an antifungal property that can be used as a natural-based denture cleanser. Purpose: To determine the color change effect of the thermoplastic nylon after immersion in 30% kelakai leaves extract. Methods: This study used a true experimental method with pre-test and post-test and control group design. The research used 24 round-shaped samples with 20 mm diameters and 3 mm thickness. There were 3 groups of immersion, including 30% kelakai leaf extract, alkaline peroxide, and distilled water. Results: The results showed the mean of color changes score for kelakai leaf extract (3,71), alkaline peroxide (2,59), and sterile distilled water (2,29). Data were analyzed using One Way ANOVA and Post Hoc Bonferroni. Conclusion: It can be concluded that there is an effect on color change of thermoplastic nylon immersed in 30% kelakai leaf extract, alkaline peroxide, and sterile distilled water. The highest to the lowest mean of color changes score was 30% kelakai leaf extract, alkaline peroxide, and distilled water. Keywords: Color changes, kelakai leaf extract 30%, thermoplastic nylon
ANTIBACTERIAL EFFECTIVENESS TEST OF KECAPI LEAVES EXTRACTS (Sandoricum koetjape) AGAINST THE GROWTH OF Porphyromonas gingivalis
Authors: Fitria Novita Nanda , Oktiani Beta Widya , Azizah Aulia
Published: April 2024

Background: Chronic periodontitis is a disease of the oral cavity that is influenced by the presence of plaque bacteria caused by Porphyromonas gingivalis which can cause chronic infection of the periodontal tissue. Kecapi leaf (Sandoricum koetjape) extract contains active compounds in the form of flavonoids, saponins, alkaloids, steroids, phenolics, and triterpenoids which function as antibacterial against the growth of Porphyromonas gingivalis. Kecapi leaf extract is used as an alternative to using herbal gluconate to prevent infection caused of Porphyromonas gingivalis. Purpose: To determine the antibacterial effectiveness of kecapi leaf extract against bacterial growth of Porphyromonas gingivalis. Methods: This study used a pure experimental research (true experimental) with post-test only with control design, consists of 7 treatment groups, including: concentrated kecapi leaf extract 5%, 10%, 15%, 25%, 50%, chlorhexidine gluconate 0.2% as positive control, and distilled water as negative control. It was repeated 7 times, the antibacterial effectiveness was assessed from Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) on BHIB and NA media by dilution method. Results: MIC on kecapi leaf extract at a concentration of 5% showed the smallest result of -0.147 and the MBC value at a concentration of 50% did not show the growth of bacterial colonies. Conclusion: Kecapi leaf extract with concentrations of 5%, 10%, 15%, 25%, 50%, and positive control was effective in inhibiting and killing bacterial growth of Porphyromonas gingivalis. Keywords: Antibacterial, Kecapi leaf extract, Porphyromonas gingivalis
TOXICITY TESTING OF CHITOSAN OF PAPUYU FISH SCALE (Anabas testudineus) TOWARD BHK-21 FIBROBLAST CELLS
Authors: Rohmah Siti , Ichrom Nahzi Muhammad Yanuar , Tri Putri Deby Kania
Published: April 2024

Background: Pulp capping is a treatment that aims to maintain the viability of the pulp tissue. Calcium hydroxide (Ca(OH)2 is a material that is often used for pulp capping procedures. However, this material does not provide a good adaptation to dentin. Therefore, an alternative material that is more biocompatible is needed, one of which is by using papuyu fish scale chitosan. papuyu fish as an alternative material must be proven to have no toxic effects. Purpose: to analyze whether the chitosan of papuyu fish scales (Anabas testudineus) is toxic to BHK-21 fibroblast cells using the MTT assay method. Methods: This study was a pure experimental study with a post-test-only design with a control group design consisting of 12 groups. The group given the chitosan treatment of papuyu fish scales consisted of 10 groups with concentrations of 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90% and 100% with 2 control groups namely control cells. and media control. Results: The results showed that the chitosan of papuyu fish scales did not have a toxic effect on BHK-21 fibroblast cells because the percentage value of cell viability of the entire treatment group was > 60% and the IC50 value was > 0.1%, which was 5.405 %. Conclusion: There was no toxic effect after administration of papuyu fish scales chitosan (Anabas testudineus) with concentrations of 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, and 100% on cells BHK-21 fibroblasts. Keywords: BHK-21 fibroblast cells, Papuyu fish scale chitosan, Toxicity test
COMPARISON OF THE ACCURACY OF MANUAL CEPHALOMETRY RADIOGRAPHIC MEASUREMENTS AND WEB-BASED DIGITAL SOFTWARE
Authors: Puspitasari Yustisia , Oemar Mattalitti Sitti Fadhilah , Novawaty Eva , Roeswahjuni Neny
Published: April 2024

Background: Determining anatomical landmarks - in the cranium, maxilla and mandible - as well as measuring skeletal and dental angles on cephalometric radiographs are supporting examinations that determine important diagnoses in orthodontic treatment. Traditionally, cephalometric analysis has been performed by tracing radiographic landmarks on acetate overlays and measuring linear and angular variables using protractor. However, despite its widespread use in orthodontics, the technique is time consuming and has several drawbacks, including a high risk of error in tracing, landmark identification, and measurement. Objective: to evaluate the difference of cephalometric measurements using manual and digital technique. Method: pre-treatment cephalometric digital radiographs of 40 patients were traced manually and digitally using WebCeph Ver. 1.0.0 computer software program by the same investigator. A total of 8 anatomical landmarks were located and five angular measurements based on Steiner Analysis were measured. Independent t-tests and Mann-Whitney tests were used to compare the difference of manual and digital measurements. Result: the p-values for SNA, SNB, ANB, I-NA, I-NB were greater than 0.05 (p>0.05). Conclusion: There were no significant difference between manual and digital tracing cephalometric technique using WebCeph for SNA, SNB, ANB, I-NA and I-NB Keywords: Cephalometric measurement, Digital cephalometric analysis, Steiner Analysis, Tracing cephalometry, WebCeph
THE CORRELATION OF OROMOTOR DYSFUNCTION TO ORAL HEALTH-RELATED QUALITY OF LIFE IN CHILDREN WITH DOWN SYNDROME
Authors: Dewi Nurdiana , Kelana Adhytya Suryo , Utami Juliyatin Putri
Published: April 2024

Background: The genetic condition known as Down syndrome (DS) is brought on by chromosome 21 trisomy. Children with DS frequently have oromotor dysfunctiont. Oromotor dysfunction in children with Down syndrome can lead to oral health issues and lower the oral health-related quality of life. Studies on the relationship between oromotor dysfunction and quality of life related to dental health in children with Down syndrome are still lacking, nevertheless. Objective: To analyze the correlation between oromotor dysfunction and oral health-related quality of life in children with DS. Methods: Total respondents used in this research was 30 children with DS and the parents in Banjarmasin Special Schools. Oromotor dysfunction was determined using the Oral Motor Assessment Scale (OMAS) and oral health-related quality of life was determined using the Modified Parent-Caregiver Perception Questionnaire (P-CPQ). The Spearman correlation test was used to analyze the correlation between oromotor dysfunction and oral health related quality of life in Down syndrome children.  Results: The Spearman correlation test showed that there was a significant correlation between oromotor dysfunction and oral health-related quality of life in children with DS with a significance value of 0.000 (p <0.05) with the correlation coefficient of 0.637. Conclusion: There was a positive and strong correlation between oromotor dysfunction and oral health-related quality of life in children with DS. The weaker the oromotor function in children with Down syndrome is, the worse the oral health-related quality of life will be.Keywords: Down syndrome, oral health-related quality of life, oromotor dysfunction.
ANTIBACTERIAL ACTIVITY TEST OF CUCUMBER PEEL EXTRACT (Cucumis sativus L.) AGAINST Streptococcus mutans BACTERIA
Authors: Dewi Rahmalia , Masyhudi Masyhudi , Alhawaris Alhawaris , Yani Sinar , Yadi Yadi
Published: April 2024

Background: Dental caries is a  process of tooth demineralization caused by acids produced from food metabolism in bacteria. One of the main etiological factors of dental caries is the microorganisms known as Streptococcus mutans bacteria. S. mutans is one of the components of human dental plaque that is associated with sucrose diet and high caries activity. Cucumber peel extract (Cucumis sativus L.) is known to have an antibacterial activity due to the presence of secondary metabolites such as flavonoids, steroids, alkaloids, saponins and phenols found in cucumber peel. Purpose: This study aimed to determine the antibacterial activity at the lowest concentration of cucumber peel extract (Cucumis sativus L.) against Streptococcus mutans bacteria. Method: This study employed the disc diffusion method with a post-test only control group design. Streptococcus mutans bacteria were cultured on Mueller Hinton Agar media, and cucumber peel extract (Cucumis sativus L.) was applied as the antibacterial agent at concentrations of 0.01 g/ml, 0.05 g/ml, 0.1 g/ml, 0.2 g/ml, 0.4 g/ml and 0.5 g/ml with seven repetitions. Results: The results of the study showed that cucumber peel extract (Cucumis sativus L.) formed inhibition zones around the paper discs against the growth of Streptococcus mutans bacteria at concentrations of 0.4 g/ml and 0.5 g/ml. Conclusion: The concentrations of 0,4 g/ml and 0,5 g/ml are the lowest concentrations of cucumber peel extract (Cucumis sativus L.) that can inhibit the growth of Streptococcus mutans bacteria. Keywords : Antibacterial, Cucumber peel, Dental Caries, Streptococcus mutans
Pergeseran Budaya Bersantai Masyarakat Kota Banjarmasin (Komparasi Pasar Lama dan Kota Lama)
Authors: Setiawan Allif Agust , Hakim Arif Rahman
Published: April 2024

There is a change in the leisure culture in the life of the Banjarmasin City people today, for example, the Mawarung culture in today's life has changed to Nongkrong culture filled with young Banjarmasin people. The point of study compares two places that are the same places to leisure in Banjarmasin, namely Pasar Lama and Kota Lama. This study uses cultural theory and leisure class theory. This type of research is included in qualitative research with a comparative study approach. Data collection techniques by means of observation, interviews and documentation. The research took place from November 2022 to January 2023. The results of this study show several different of the two places to leisure from clothing, places, visitors, menus, facilities, to topics of conversation. There are three main elements that make a cultural shift occur in the two places to leisure, namely the different ideas between the two places, visitor activities, and artifacts or characteristics of places to leisure. The conclusion of this study shows that there is a change in the leisure culture of the Banjarmasin City people from three cultures namely ideas, activities and buildings. Ideas of the past at Pasar Lama and ideas of the present at Kota Lama. Visitor activities at the Pasar Lama are purely leisure and visitor activities at the Kota Lama are leisure while showing off their social status. Most Pasar Lama building represents a simple place and most Kota Lama building represents an aesthetic place. The nongkrong culture as conspicuous leisure in the Pasar Lama was replaced by the culture of nongkrong as conspicuous consumption in the Kota Lama.
Mengikis Ketergantungan: Dampak Program Pemberdayaan Terhadap Kehidupan Sosial Ekonomi Masyarakat Desa Sungai Pasir Kabupaten Sukamara
Authors: Rifanny Muhammad Rizky , Hamid Ismar
Published: April 2024

The life of the fishing community in Sungai Pasir Village depends on the Fisherman Boss (Juragan Kampung), which makes the fishing community unable to live independently, until an empowerment programme through Vaname Shrimp farming for fishing communities in Sungai Pasir Village emerged. This research aims to analyse the community empowerment approach applied and the impact of the empowerment programme through vaname shrimp farming on the socio-economic life of the Sungai Pasir Village community. The theory used in this research is the theory of community empowerment (Jim lfe). The research approach used is qualitative, with a case study research type. Data collection used participant observation, in-depth interviews and documentation. Data was analysed using data reduction, data presentation and conclusion drawing. The results show that the vaname shrimp empowerment programme in Sungai Pasir Village has an impact on the socio-economic life of the community. The impacts are: the opening of employment opportunities for the community; a change in the profession of the community from fishermen to pond farmers; the emergence of community independence; increased community awareness to save; and, the birth of small micro businesses. The community conducts vaname shrimp farming activities in groups of 25 members. The group is called "Mina Barokah" and is responsible for the cultivation of vaname shrimp from seedling stocking to harvesting. By providing resources, opportunities and knowledge to the community, the local government has empowered the community through vaname shrimp farming, increasing their income and independence.