bluuebunny/crossref_metadata_2025 huggingface dataset:
The Role of Leadership in Managing Organisational Culture Change in the Context of Information Technology Implementation
Authors: Zen Agustian , Yanti Selfi , Hutomo Mahargi Rizki , Kraugusteeliana Kraugusteeliana , Arisutama Herman Yosef
Published: August 2023

The rapid development of information technology has affected many organisations in various sectors. The implementation of information technology often involves changes in work processes, organisational structure and overall organisational culture. The background of this study aims to investigate the role of leadership in managing organisational culture change in the context of information technology implementation. The current research type is qualitative. Data collection techniques include listening and recording important information to conduct data analysis through data reduction, data display, and conclusion drawing. The study arrived at a statement that in the context of information technology implementation in organisations, organisational culture change becomes a critical factor affecting the success and sustainability of the use of such technology. Leadership plays an important role in managing such organisational culture change. Through effective communication, appropriate education and training, active participation and involvement of organisational members, strong team building, recognition and rewards, gradual change management, and continuous evaluation and adjustment, leadership can create an enabling environment for the adaptation and utilisation of information technology.
Rancang Bangun Aplikasi GIS Pusat Oleh-Oleh Toraja Berbasis Web
Authors: M. Sabir Fitriana , Asrul Asrul , Nurul Puteri Annisa , Amiruddin Amran , Mashud Mashud , Patalangi Sidik Sakti
Published: August 2023

Oleh-oleh sering disinonimkan dengan souvenir, buah tangan atau cinderamata adalah sesuatu yang dibawa oleh seseorang ke rumahnya untuk mengenang daerah yang telah dikunjungi, terutama para wisatawan. Pendatang atau wisatawan yang ingin membeli oleh-oleh khas Tana Toraja biasanya hanya mengandalkan informasi yang terbatas dari orang per orang sehingga hasil pencariannya pun tidak efektif dan efisien. Tujuan dari penelitian ini adalah untuk merancang suatu sistem informasi geografis pusat oleh-oleh khas Toraja berbasis web. Analisis yang digunakan pada penelitian ini adalah analisis PIECES yang mengatur Performance, Information, Economy, Control, Eficiency Dan Services. Perancangan proses menggunakan UML, bahasa pemrograman PHP sebagai pengkodean yang digunakan, untuk pengujian dengan menggunakan pengujian aplikasi menggunakan UAT dan MySQL sebagai database[1]. Berdasarkan hasil pengujian yang diperoleh dari kuesioner sebesar 89,4% yang menunjukkan bahwa sistem yang dirancang berjalan baik dan sesuai dengan fungsinya. Pada penelitian ini menghasilkan sistem informasi geografis pusat oleh-oleh khas Toraja berbasis web.
The Role of Management Information Systems in Human Resource Competency Development
Authors: Fitria Namira , Wijayanti Isa , Santoso Ade Budi , Romadon Saiful , Kraugusteeliana Kraugusteeliana
Published: August 2023

In the era of globalisation and advances in information technology, companies or organisations are faced with increasingly fierce competition. Human Resources (HR) is one of the key factors that determine the success of a company in achieving its strategic goals. The competence of strong and qualified human resources is an important capital in increasing the competitiveness of the company. This research aims to identify and analyse how Management Information Systems (MIS) can effectively support the development of HR competencies, as well as identify factors that influence the application of MIS in the context of HR development. The current research type is qualitative. Data collection techniques include listening and recording important information to conduct data analysis through data reduction, data display, and conclusion drawing. The study results arrive at the expression that management information system plays a very important role in the development of HR competencies in various organisations and companies. It serves as a strategic tool to collect, store, manage and analyse HR-related data. With management information systems, companies can conduct efficient planning related to employee competency development, identify training needs, and monitor and evaluate the impact of competency development programmes.
The Importance of Innovative Leadership in Improving Organisational Readiness for Technology Disruption
Authors: Sunarmo Sunarmo , Rini Puspa , Nurdiana Diah , Albart Nicko , Hasanah Siti
Published: August 2023

The rapid development of technology has led to disruption in various industries and sectors. Technological disruption refers to a fundamental change in the way businesses and organisations operate due to the adoption of new technologies that change traditional business models. This research aims to illustrate the importance of innovative leadership in improving organisational readiness in the face of technological disruption. The current research type is qualitative. Data collection techniques include listening and recording important information to conduct data analysis through data reduction, data display, and conclusion drawing. The study results show that innovative leadership plays a very important role in improving organisational readiness to face technological disruption. Technological disruption has fundamentally changed the business landscape, and organisations need to adopt innovative approaches to remain relevant, competitive and sustainable in this dynamic environment. Innovative leadership helps organisations understand the impact of technology, deal with the changing business environment, and improve competitiveness by creating competitive advantage through innovation.
Sistem Pendukung Keputusan Berbasis Web Logika Fuzzy Metode Tsukamoto Dalam Penentuan Pilihan Kejuruan SMK Negeri 1 Waingapu
Authors: Ina Theresia Satri , Hariadi Fajar , Malo Raynesta Miakela Indri
Published: August 2023

Sekolah menengah kejuruan (SMK) Negeri 1 Waingapu berusaha meningkatkan mutu pendidikan dan pengajaran dengan pemilihan jurusan yang tepat bagi para siswa-siswinya. Hal ini dicapai dengan menentukan jurusan berdasarkan pertimbangan Nilai Matematika, Nilai Bahasa Indonesia, Nilai Bahasa Inggris, Nilai Ilmu Pengetahuan Alam dalam menentukan jurusan siswa-siswi. Namun dengan cara manual dengan melihat dan memutuskan data nilai satu per satu membutuhkan waktu yang cukup lama. Oleh karena itu dibuatlah metode penentuan jurusan siswa-siswi dengan menggunakan fuzzy tsukamoto. Kriteria fuzzy yang digunakan terdiri dari 7 kriteria dan 128 aturan fuzzy. Hasil yang didapatkan berdasarkan pengujian akurasi menggunakan data siswa yang diterima pada tahun sebelumnya sebanyak 232 Orang memiliki tingkat akurasi 60%. Berdasarkan hasil ini dapat disimpulkan bahwa hasil fuzzy yang didapat sudah cukup akurat untuk digunakan dalam penentuan jurusan bagi siswa-siswa di SMKN 1 Waingapu. Berdasarkan hasil pengujian blackbox Sistem Pendukung Keputusan penentuan jurusan menggunakan fuzzy tsukamoto telah berjalan dan berfungsi dengan baik. Tingkat akurasi yang dihasilkan dari perbandingan antara hasil seleksi oleh sekolah dan sistem pendukung keputusan memiliki tingkat kesamaan 60%. Hal ini dapat dijadikan pertimbangan oleh pihak SMK Negeri 1 Waingapu dalam memutuskan tata cara mana yang akan digunakan oleh sekolah ke depannya.
Pemodelan Sistem Penerimaan Anggota Baru dengan Unified Modeling Language (UML) (Studi Kasus: Programmer Association of Battuta)
Authors: Wayahdi M. Rhifky , Ruziq Fahmi
Published: August 2023

Sistem yang baik adalah sistem yang dirancang dengan proses analisis mendalam serta terdokumentasi dengan standar yang ditetapkan, serta memperhatikan siklus hidup pengembangan sistem. UML dapat membantu dalam proses pemodelan pengembangan sistem atau perangkat lunak. Dalam penelitian ini, pemodelan dengan UML dilakukan pada sistem penerimaan anggota baru di Programmer Association of Battuta yang bertujuan untuk memudahkan dalam pengembangan aplikasi dikemudian hari. Pemodelan sistem penerimaan anggota baru dimulai dengan tahap pendaftaran, ujian tahap 1, ujian tahap 2, sampai laporan akhir diterima atau tidaknya menjadi anggota baru. Penelitian ini hanya membahas alur penerimaan anggota baru dan tidak membahas alur sistem yang lainnya. Pengumpulan data yang digunakan dalam penelitian ini adalah dengan teknik observasi dan studi literatur. Penelitian ini menggunakan pemodelan sistem dengan UML yang mencakup diagram-diagram tertentu, yaitu use case diagram digunakan untuk memodelkan hubungan/interaksi antara pengguna sistem, activity diagram memperlihatkan alur atau aktivitas sistem, sequence diagram menjelaskan sistem secara lebih detail, dan class diagram menggambarkan hubungan antar class dari sistem yang dirancang. Setiap diagram dalam UML memiliki tugas dan fungsi masing-masing. Pemodelan sistem dengan UML memberikan beberapa keunggulan, baik dari segi perancangan dan pengembangan, ataupun pada tahap pemahaman dan komunikasi antara developer dan client. UML akan memungkinkan developer untuk melakukan analisis yang lebih mendalam dan perancangan yang lebih baik dan maksimal sebelum memulai merancang aplikasi.
THE ROLE OF THE US ARMED FORCES IN DETERRING ILLEGAL IMMIGRATION DURING THE TRUMP PRESIDENCY (2017–2021)
Authors: MAZURIN Oleksii
Published: August 2023

The article reveals the specifics of the involvement of the US National Guard and the US AF performing the tasks of the US southern border security during the presidency of Donald Trump. The author analyzes the reasons for the involvement of military units, the scope of their tasks, and describes the specific tasks performed by military personnel in cooperation with the US Customs and Border Protection. Changes in the nature of the use of army units during the operations «Guardian Support» and «Faithfull Patriot» in 2018 and after the declaration of a state of emergency on the border with Mexico in 2019 are revealed. The main problems encountered by the U.S. Department of Defense in its operations at the border, in the context of fierce domestic political opposition to Donald Trump’s immigration policy, were separately examined. It is argued that the involvement of the US AF in solving migration problems on the U.S. southern border had both potential benefits and risks. On the one hand, support in the areas of intelligence, transportation, and logistics has become an important element in curbing illegal immigration and drug trafficking. The deployment of military units was a foreign policy signal that the USA was taking border security seriously. On the other hand, the risks concerned the possibility of using the armed forces to perform police functions, which is prohibited by the Posse Comitatus Act. In addition, there were questions about the politicization of the army’s role, inefficient use of military resources, and the separation of units from the process of combat training.
Keywords
US AF, internal function of the AF, migration, US-Mexico border, border security, Operation «Guardian Support», Operation «Faithfull Patriot».
Programa de aquisição de alimentos da agricultura familiar (PAA) – modalidade leite: concepção, instrumentos e arranjo institucional intersetorial
Authors: Silva Rita de Cássia de Andrade , Matos Marta Maria Souza , Pereira Neto Manoel , Neves Josemir Araújo , Novaes Luciano Patto , Urbano Stela Antas , Araújo Emmanuella de Oliveira Moura , Rangel Adriano Henrique do Nascimento
Published: August 2023

Este artigo se propõe a discutir a concessão, os instrumentos e o arranjo institucional intersetorial do Programa de Aquisição de Alimentos da Agricultura Familiar (PAA) – Modalidade Leite, criado em 2003 e vinculado às ações estruturantes do Programa Fome Zero. O PAA-Leite é uma estratégia de governo cujo objetivo, entre outros, é fomentar a produção da agricultura familiar e prestar assistência alimentar às populações em situações de risco. A perspectiva teórica adotada articula-se à compreensão do PAA-Leite como parte de um sistema de proteção social que prioriza e defende o direito de todas as pessoas à alimentação saudável e à soberania alimentar. Recorre-se às análises documentais de leis, decretos, resoluções, planos e outros documentos para apresentar, situar e problematizar o PAA-Leite no campo das políticas públicas de combate à fome e afirmação da segurança alimentar e nutricional. Conclui-se que o PAA-Leite, a despeito das contradições e limites de sua execução por municípios e estados, tem um desenho institucional ousado, inovador, relevante socialmente, além de potencial para garantir o acesso a alimentos com alto valor nutricional para pessoas em situação de vulnerabilidade social, criar condições de prosperidade e autonomia econômica para as famílias fornecedoras de leite e ampliar oportunidades de permanência no campo, em especial para a juventude.
THE INFLUENCE OF LEVEL CROSSINGS ON ECONOMIC GROWTH AND SOCIAL DYNAMICS IN CIREBON CITY
Authors: Novriani Shinta , Hariani Mira Lestira , Rohman Fathur
Published: August 2023

Cirebon City is one of the metropolitan areas stipulated in PP No. 26 of 2008 namely RTRWN as a National Activity Center (PKN) in developing metropolitan areas, especially in Ciayumajakuning area. The Cirebon City has become the center of economic growth, resulting in an increase in the flow of urbanization and in line with social dynamics that must be considered due to urban city activities. One of the impacts of urban cities is the increase in traffic density, causing a decrease in traffic performance. The purpose of this study is to determine the existing conditions of railroad level crossings in Cirebon City and see their impact on traffic performance, social dynamics and economic growth in Cirebon City.  The research method used is a survey method, including traffic volume surveys, train frequency surveys, and calculating queue lengths and calculating delays.  Based on the result of a survey on 8 roads in the Cirebon City with an average capacity of 3191 smp/hour, the degree of saturation is 0.5, the Level of Service value is C, which means the flow is stable, the speed can be controlled by traffic. However, if it is review based on an economic analysis related to the loss of community income due to level crossings if it is assumed that the average income of the people of Cirebon City is IDR 2.304.943.51 each individual experiences losses ranging from IDR 0 – IDR 768.314 for one month depending on the how long the individual experiences waiting time at a level crossing. If analyzed based on fuel consumption, each individual experiences a loss of IDR 0 – IDR 30.294 per month depending on the waiting time and the type of fuel used and if it is associated with the economic growth of Cirebon City, it is expected to increase the contribution of GRDP for each sector and respondents feel that level crossing are very important affect their travel interest.
ANALYSIS OF MAPPING OF THE LEVEL OF FLOOD PRONECTION IN BOJONEGORO REGENCY BASED ON GEOGRAPHIC INFORMATION SYSTEM
Authors: Mushthofa Mushthofa , Qomaruddin Mochammad
Published: August 2023

Floods are natural disasters that often occur in various parts of the world, especially in flood-prone areas. Floods occur when water from rivers, lakes or seas overflows beyond its holding capacity. Floods can cause great damage to infrastructure, plants, animals and people. To overcome floods that occur frequently every year, it is necessary to map areas prone to flooding accurately and quickly using GIS which can be used to accurately monitor the location and area of ​​the area that is experiencing flooding. This study aims to analyze flood-prone areas and compile maps of flood-prone areas and describe the conditions of flood-prone areas in Bojonegoro Regency based on Geographic Information Systems (GIS). Data processed using GIS include: RBI Map of Bojonegoro Regency, River Map, Soil Type Map, Rainfall Data, Landsat Imagery Data, Flood incident data in Bojonegoro Regency. From the results of data processing, the results of the analysis are as follows: The level of flood-prone areas in Bojonegoro Regency is divided into 3 classes, namely: very vulnerable class of 49,963.671 Ha or around 21.66% of the sub-districts in Bojonegoro including the District: Margomulyo , Ngraho, Padangan, Kasiman, Malo, Purwosari, Trucuk, Kalitidu, Ngasem, Bojonegoro, Kapas, Dander, Balen, Kanor, Baureno, Sumberrejo, Kepohbaru and Gondang. The vulnerable class of 173,162.171 Ha or around 75.05% is in sub-districts including: Margomulyo, Ngraho, Tambakrejo, Kedewan District, Malo, Trucuk, Sekar, Ngambon, Ngasem, Gondang, Bubulan, Dander, Temayang, Sugihwaras and Kedungadem. The non-prone class is 7,580.157 ha or 3.29% in the sub-districts including: Margomulyo, Ngraho, Tambakrejo, Kedewan, Malo, Trucuk, Sekar, Ngambon, Gondang, Temayang, Sugihwaras and Kedungadem. Areas that have a high level of vulnerability are around the Bengawan Solo River which crosses Bojonegoro Regency. This can be caused because the area around the Bengawan Solo River has a height of <25 m and frequent flooding from the upstream and tributaries of the Bengawan Solo River.
ANALYSIS AND DESIGN REINFORCED CONCRETE CONSTRUCTION STRUCTURE OF 4 FLOOR HOTEL IN KUNINGAN
Authors: Roesdiana Tira , Perdana Renaldi Indra
Published: August 2023

Planning for a 4-storey hotel in Kuningan is projected to support supporting facilities for the tourism sector in Kuningan Regency, supporting facilities like this are really needed by Kuningan Regency which has great potential in the tourism sector and is proven by the continuing increase in the number of tourists every year, with the development of Kuningan Regency and the increasingly widespread the construction of multi-storey buildings is needed planning in order to make efficient use of land. To support the availability of tourism support facilities, this research will examine the planning of hotel building structures based on SNI 2847-2019, SNI 1727-2020 and SNI 1726-2019 and calculate the budget plan for the structural work. Referring to these rules, the dimensions of the structural elements and the need for structural reinforcement can be produced that meet the rules and can also support the work force and loads received on a building including earthquake loads, wind loads and rain loads. The cost of building a 4-storey hotel building in this study is Rp. 26,712,400,000.00 (Twenty Six Billion Seven Hundred Twelve Million Four Hundred Thousand Rupiah), and the cost of building a one square meter building is Rp. 4,345,716.00 (Four million three hundred forty-five million seven hundred and sixteen thousand rupiah).
Çatışma Çözümünde AGİT'in Avantajları ve Sınırlılıkları
Authors: TANRIVERDİ ŞEYŞANE Görkem
Published: August 2023

Bu makale, Avrupa Güvenlik ve İşbirliği Örgütü (AGİT) örneğine odaklanarak bölgesel örgütlerin çatışma çözümündeki konumlarını anlamaya çalışmaktadır. Mevcut literatür, bölgesel örgütlerin çatışma çözümündeki konumlarını çoğunlukla avantajları ve sınırlılıkları açısından küresel örgütlerle karşılaştırmaktadır. Makale, özellikle Soğuk Savaşın sona ermesinden sonra bölgesel örgütlerin çatışma çözümündeki konumlarını analiz edebilmek için kurumsallaşma kapasitesi, ortak tarih ve/veya ortak değerlere sahip olma, coğrafi yakınlık, homojenlik, çatışmaya aşinalık, demokratik üyelere sahip olma ve sahip olunan kaynaklar şeklinde yedi spesifik kriter belirlemektedir. Détente döneminde konferanslar serisi olarak ortaya çıkan AGİT, bu yedi kriteri incelemek için güçlü bir bölgesel örgüt örneği sunmaktadır. Makale, üç bölüme ayrılmıştır. Birinci bölüm, uluslararası belgeleri inceleyerek bölgesel örgütlerin çatışma çözümündeki rolüne işaret eder ve çatışma çözümündeki pozisyonlarını analiz etmek için yedi kriter belirler. İkinci bölüm, AGİT’in çatışma çözümü yaklaşımının gelişimini tartışır. Üçüncü bölüm ise belirlenen kriterler çerçevesinde AGİT’in
çatışma çözümündeki avantajlarını ve sınırlarını analiz etmektedir. Makale, çatışma çözümünde bölgesel örgütler için avantaj olarak tanımlanan kriterlerin AGİT'in çatışma çözümü eylemlerinde belirleyici bir avantaj oluşturmadığı sonucuna varmaktadır.
Student Engagement in Online Learning Among Undergraduate Nursing Students
Authors: Sugiharto Firman , Hara Permana Ryan , Hermayanti Yanti
Published: August 2023

Aims: Student engagement (SE) is a significant factor for success in online learning. The low of SE will impact students' academic achievement.
Purpose: This study aimed to describe SE in online learning at the Faculty of Nursing, Universitas Padjadjaran. 
Methods: This study was quantitative descriptive research. The population was undergraduate nursing students (N=862). The sample criteria were that respondents were active students of the Faculty of Nursing, Universitas Padjadjaran for the 2020/2021 period from the Jatinangor and Pangandaran campuses. The sampling technique was total sampling with a response rate of 64,3% (n=554). Data were collected using the Online Community and Student Engagement Scale. Data were analyzed using descriptive statistics and presented in frequency distribution tables. 
Results: The results showed that more than half of students (52.7%) had a low category of SE, and nearly half (47.3%) have shown a high category of SE in online learning. Students had low levels of Community Building with the Instructor, Community Building with Classmates, and Engagement with Learning (57.4%; 58.3%; and 51.8%, respectively). The SE level that the respondent currently has has the potential to be increased along with the ongoing process during the lecture period.
Conclusion: More than half of students had a low category of SE in online learning this could have a negative impact on student achievement and educational completion rates. Therefore, intense interactions through discussions between students and lecturers, constructive feedback, and motivational support are highly recommended to be provided by the faculty and peers for improving the SE.
Neorealist Analysis of Security Dilemma in Cyberspace; A Quantitative Study
Authors: Arslan Ahmet Selçuk
Published: August 2023

Two crucial factors have urged IR academia to account for state behavior in cyberspace: the increasing volume of cyber attacks and the rising scale of damage induced by these attacks. This has led to a series of initiatives appealing to the grand theories of IR in order to scrutinize state behavior in depth. Following a similar pattern, this work intends to contribute to IR academia by presenting a neorealist analysis of state behavior in cyberspace by relying on quantitative methods. Two regression analyses, one using a linear and the other using a negative binomial algorithm, were conducted using a dataset consisting of 4,099 samples. The analyses indicate that as states build more cyber security capacity, they tend to execute more disruptive actions against other states in cyberspace. Both regression models were subsequently trained using artificial neural networks (ANNs) and showed improvements in their metrics compared to their traditional regression counterparts.
Optimization of slice configuration of steel coils.
Authors: Birgin E. G. , Ertel Paula C. R. , Kolossoski O. , Lopes M. Moreira , Marcondes D. S. , Toledo Franklina M. B.
Published: August 2023

Prior to the manufacturing of hermetic compressor lids, the industrial partner requires the production of quasi-circular pieces of steel, sliced from a coil. The coil consists in a wide plate of steel that is rolled for logistical reasons. On the other hand, these quasi-circular shapes are defined as regular circular disks, but allowing deformities under some restrictions, which gives margin for some optimisations. The slicing process of such pattern produces a considerable amount of scrap, that besides being recycled, causes cost for the partner. This work aims to find a slicing pattern for those coils in order to maximise the number of quasi-circles produced, consequently minimising the production of scrap. In addiction, the slicing pattern should also be compatible with the limitations of the machinery of the industrial partner and their safety policies for workers.
PENGARUH BRAND TRUST DAN KUALITAS PRODUK TERHADAP KEPUTUSAN PEMBELIAN HIJAB PADA TOKO TREND HIJAB MALANG
Authors: Anggraeni Hayu , Rachmi Asminah
Published: August 2023

Riset ini bertujuan untuk menganalisis pengaruh kepercayaan merek serta mutu produk terhadap keputusan pembelian hijab di Toko Trend Hijab Malang. Riset ini merupakan riset kuantitatif dengan menggunakan tehnik akumulasi fakta kuesioner. Sampel penelitian ini berjumlah 100 jiwa yang dipilih dengan teknik purposeful sampling dan konsumen Toko Trend Hijab. Hasil analisis menunjukkan bahwa variabel kepercayaan merek berpengaruh positif parsial terhadap variabel keputusan pembelian serta variabel mutu produk berpengaruh positif parsial terhadap variabel keputusan pembelian. Hasil uji F menunjukkan bahwa kepercayaan merek serta mutu produk berpengaruh positif terhadap keputusan pembelian. Koefisien determinasi dari hasil tersebut yakni 65,5%.
Development and validation of a rapid visual technique for left ventricular hypertrophy detection from the electrocardiogram
Authors: Somani Sulaiman , Hughes J. Weston , Ashley Euan A. , Witteles Ronald M. , Perez Marco V.
Published: August 2023

Introduction

Left ventricular hypertrophy (LVH) detection techniques on by electrocardiogram (ECG) are cumbersome to remember with modest performance. This study validated a rapid technique for LVH detection and measured its performance against other techniques.

Methods

This was a retrospective cohort study of patients at Stanford Health Care who received ECGs and resting transthoracic echocardiograms (TTE) from 2006 through 2018. The novel technique, Witteles-Somani (WS), assesses for S- and R-wave overlap on adjacent precordial leads. The WS, Sokolow-Lyon, Cornell, and Peguero-Lo Presti techniques were algorithmically implemented on ECGs. Classification metrics, receiver-operator curves, and Pearson correlations measured performance. Age- and sex-adjusted Cox proportional hazard models evaluated associations between incident cardiovascular outcomes and each technique.

Results

A total of 53,333 ECG-TTE pairs from 18,873 patients were identified. Of all ECG-TTE pairs, 21,638 (40.6%) had TTE-diagnosed LVH. The WS technique had a sensitivity of 0.46, specificity of 0.66, and AUROC of 0.56, compared to Sokolow-Lyon (AUROC 0.55), Cornell (AUROC 0.63), and Peguero-Lo Presti (AUROC 0.63). Patients meeting LVH by WS technique had a higher risk of cardiovascular mortality [HR 1.18, 95% CI (1.12, 1.24), P < 0.001] and a higher risk of developing any cardiovascular disease [HR 1.29, 95% CI (1.22, 1.36), P < 0.001], myocardial infarction [HR 1.60, 95% CI (1.44, 1.78), P < 0.005], and heart failure [HR 1.24, 95% CI (1.17, 1.32), P < 0.001].

Conclusions

The WS criteria is a rapid visual technique for LVH detection with performance like other LVH detection techniques and is associated with incident cardiovascular outcomes.
Universal skepticism of ChatGPT: a review of early literature on chat generative pre-trained transformer
Authors: Watters Casey , Lemanski Michal K.
Published: August 2023

ChatGPT, a new language model developed by OpenAI, has garnered significant attention in various fields since its release. This literature review provides an overview of early ChatGPT literature across multiple disciplines, exploring its applications, limitations, and ethical considerations. The review encompasses Scopus-indexed publications from November 2022 to April 2023 and includes 156 articles related to ChatGPT. The findings reveal a predominance of negative sentiment across disciplines, though subject-specific attitudes must be considered. The review highlights the implications of ChatGPT in many fields including healthcare, raising concerns about employment opportunities and ethical considerations. While ChatGPT holds promise for improved communication, further research is needed to address its capabilities and limitations. This literature review provides insights into early research on ChatGPT, informing future investigations and practical applications of chatbot technology, as well as development and usage of generative AI.
An automatic preselection strategy for magnetotelluric single-site data processing based on linearity and polarization direction
Authors: Chen Hao , Zhang Lili , Ren ZhengYong , Cao Hui , Wang Gang
Published: August 2023

The magnetotelluric response function can be severely disturbed by cultural electromagnetic noise. The preselection strategy is one of the effective ways to remove the influence of noise when calculating the response function. This study proposed three new parameters (the amplitude ratio predicted amplitude ratio and linear coherence (PLcoh) between the predicted and observed electric fields and the dispersion degree of the magnetic polarization direction (DDpol)) to detect noisy data, making the preselection strategy automatic. The first two were used to evaluate the linearity of binary linear regression to constrain incoherent noise, while the last was used to evaluate the magnetic polarization direction to constrain coherent noise. Finally, the technique is illustrated by applying it to two field datasets and comparing it with the previous studies. The results showed that these parameters can be used to effectively identify contaminated data, and a reliable response function can be obtained by using these parameters to extract high-quality data when intermittent noise contaminates field data.
The sizzle and fizzle of teacher evaluation in the United States and the selective use of research evidence
Authors: Gitomer Drew H. , Marshall Brittany L.
Published: August 2023

In 2009, the United States funded the largest federal educational reform effort in the nation’s history. Referred to as Race to the Top (RTTT), a cornerstone of this effort was the high-stakes evaluation of all teachers, with a significant emphasis on the use of highly researched statistical methods that ascribed changes in student test scores to a teacher’s quality. The widespread endorsement of these policies across a broad range of the political spectrum was based on a theory of action that faced technical, organizational, and political challenges. Enthusiasm for these evaluation efforts was substantially muted in a mere 5 years. Among a number of factors, we argue that the framing of the problem together with privileging particular lines of research and voices, as well as the lack of consideration of other frames and attention to other research and voices, resulted in an evidence base that was wholly insufficient to justify the large-scale policy changes that were enacted.
Gene–diet interaction analysis using novel weighted food scores discovers the adipocytokine signaling pathway associated with the development of type 2 diabetes
Authors: Apio Catherine , Chung Wonil , Moon Min Kyong , Kwon Oran , Park Taesung
Published: August 2023

Introduction

The influence of dietary patterns measured using Recommended Food Score (RFS) with foods with high amounts of antioxidant nutrients for Type 2 diabetes (T2D) was analyzed. Our analysis aims to find associations between dietary patterns and T2D and conduct a gene-diet interaction analysis related to T2D.

Methods

Data analyzed in the current study were obtained from the Korean Genome and Epidemiology Study Cohort. The dietary patterns of 46 food items were assessed using a validated food frequency questionnaire. To maximize the predictive power of the RFS, we propose two weighted food scores, namely HisCoM-RFS calculated using the novel Hierarchical Structural Component model (HisCoM) and PLSDA-RFS calculated using Partial Least Squares-Discriminant Analysis (PLS-DA) method.

Results

Both RFS (OR: 1.11; 95% CI: 1.03- 1.20; P = 0.009) and PLSDA-RFS (OR: 1.10; 95% CI: 1.02-1.19, P = 0.011) were positively associated with T2D. Mapping of SNPs (P < 0.05) from the interaction analysis between SNPs and the food scores to genes and pathways yielded some 12 genes (CACNA2D3, RELN, DOCK2, SLIT3, CTNNA2, etc.) and pathways associated with T2D. The strongest association was observed with the adipocytokine signalling pathway, highlighting 32 genes (STAT3, MAPK10, MAPK8, IRS1, AKT1-3, ADIPOR2, etc.) most likely associated with T2D. Finally, the group of the subjects in low, intermediate and high using both the food scores and a polygenic risk score found an association between diet quality groups with issues at high genetic risk of T2D.

Conclusion

A dietary pattern of poor amounts of antioxidant nutrients is associated with the risk of T2D, and diet affects pathway mechanisms involved in developing T2D.
Latest advances in the regulatory genes of adipocyte thermogenesis
Authors: Nie Tao , Lu Jinli , Zhang Hua , Mao Liufeng
Published: August 2023

An energy imbalance cause obesity: more energy intake or less energy expenditure, or both. Obesity could be the origin of many metabolic disorders, such as type 2 diabetes and cardiovascular disease. UCP1 (uncoupling protein1), which is highly and exclusively expressed in the thermogenic adipocytes, including beige and brown adipocytes, can dissipate proton motive force into heat without producing ATP to increase energy expenditure. It is an attractive strategy to combat obesity and its related metabolic disorders by increasing non-shivering adipocyte thermogenesis. Adipocyte thermogenesis has recently been reported to be regulated by several new genes. This work provided novel and potential targets to activate adipocyte thermogenesis and resist obesity, such as secreted proteins ADISSP and EMC10, enzyme SSU72, etc. In this review, we have summarized the latest research on adipocyte thermogenesis regulation to shed more light on this topic.
Risk assessment of the Xigou debris flow in the Three Gorges Reservoir Area
Authors: Zhang Anle , Dai Zhenwei , Qin Weibing , Fu Xiaolin , Gao Jingxuan , Guo Lianjun , Liu Liang , Jiang Xiannian , Wang Heng
Published: August 2023

On June 18, 2018, under the influence of heavy rainfall, a debris flow disaster broke out in Xigou village of the Three Gorges Reservoir Area in Chongqing, causing some residential houses to be buried along with great economic losses. The on-site investigation found many loose solid material sources in the debris flow gully. Under the conditions of heavy rainfall, debris flows are prone to occur again, which would seriously threaten the lives and property of nearby residents. In this paper, taking the Xigou debris flow as a research case, numerical simulation by rapid mass movements simulation (RAMMS) is used to invert the movement process of the 2018 debris flow event; the dynamic calculation parameters of the Xigou debris flow event are obtained; a quantitative hazard prediction of debris flows with different recurrence intervals (30, 50, and 100 years) is carried out in the study area; and risk assessment is conducted based on the vulnerability characteristics of the disaster-bearing bodies in the study area. The results show that the maximum accumulation thickness of debris flow in the 30-year, 50-year, and 100-year recurrence intervals is 6.54 m, 10.18 m, and 10.00 m, respectively, and the debris flow in the 100-year recurrence interval has the widest influence range and greatest hazard. The low-, medium-, and high-risk areas account for 75%, 23%, and 2%, respectively. The high-risk area mainly includes some buildings near the #1 and #2 gullies. This study provides support for the prevention and control of potential debris flow disasters in Xigou village and a scientific basis for disaster prevention and mitigation in the Three Gorges Reservoir area.
Lessons from clinical implementation of a preemptive pharmacogenetic panel as part of a testing pilot program with an employer-sponsored medical plan
Authors: Norris Madeline , Dalton Rachel , Alam Benish , Eddy Elizabeth , Nguyen Khoa A. , Cavallari Larisa H. , Sumfest Jill , Wiisanen Kristin , Cicali Emily J.
Published: August 2023

Introduction: This manuscript reports on a pilot program focused on implementing pharmacogenetic testing within the framework of an employer-sponsored medical plan at University of Florida (UF) Health. The aim was to understand the challenges associated with program implementation and to gather insights into patient attitudes towards PGx testing.

Methods: The pilot program adopted a partially preemptive approach, targeting patients on current prescriptions for medications with relevant gene-drug associations. Patients were contacted via phone or through the MyChart system and offered pharmacogenetic testing with no additional direct costs.

Results: Of 244 eligible patients, 110 agreed to participate. However, only 61 returned the mailed DNA collection kits. Among these, 89% had at least one potentially actionable genotype-based phenotype. Post-test follow-up revealed that while the majority viewed the process positively, 71% preferred a consultation with a pharmacogenetic specialist for better understanding of their results. Barriers to implementation ranged from fatigue with the healthcare system to a lack of understanding of the pharmacogenetic testing and concerns about privacy and potential misuse of genetic data.

Conclusion: The findings underscore the need for clearer patient education on pharmacogenetic results and suggest the importance of the role of pharmacogenetic-trained pharmacists in delivering this education. They also highlight issues with relying on incomplete or inaccurate medication lists in patients’ electronic health record. The implementation revealed less obvious challenges, the understanding of which could be beneficial for the success of future preemptive pharmacogenetic implementation programs. The insights from the pilot program served to bridge the information gap between patients, providers, and pharmacogenetic -specialists, with the ultimate goal of improving patient care.
Development of a bivalent protein-based vaccine candidate against invasive pneumococcal diseases based on novel pneumococcal surface protein A in combination with pneumococcal histidine triad protein D
Authors: Afshari Elnaz , Ahangari Cohan Reza , Shams Nosrati Mohammad Sadegh , Mousavi Seyed Fazlollah
Published: August 2023

Extensive efforts have been made toward improving effective strategies for pneumococcal vaccination, focusing on evaluating the potential of multivalent protein-based vaccines and overcoming the limitations of pneumococcal polysaccharide-based vaccines. In this study, we investigated the protective potential of mice co-immunization with the pneumococcal PhtD and novel rPspA proteins against pneumococcal sepsis infection. The formulations of each antigen alone or in combination were administered intraperitoneally with alum adjuvant into BALB/c mice three times at 14-day intervals. The production of antigen-specific IgG, IgG1 and IgG2a subclasses, and IL-4 and IFN-γ cytokines, were analyzed. Two in vitro complement- and opsonophagocytic-mediated killing activities of raised antibodies on day 42 were also assessed. Finally, the protection against an intraperitoneal challenge with 106 CFU/mouse of multi-drug resistance of Streptococcus pneumoniae ATCC49619 was investigated. Our findings showed a significant increase in the anti-PhtD and anti-rPspA sera IgG levels in the immunized group with the PhtD+rPspA formulation compared to each alone. Moreover, the results demonstrated a synergistic effect with a 6.7- and 1.3- fold increase in anti-PhtD and anti-rPspA IgG1, as well as a 5.59- and 1.08- fold increase in anti-PhtD and anti-rPspA IgG2a, respectively. Co-administration of rPspA+PhtD elicited a mixture of Th-2 and Th-1 immune responses, more towards Th-2. In addition, the highest complement-mediated killing activity was observed in the sera of the immunized group with PhtD+rPspA at 1/16 dilution, and the opsonophagocytic activity was increased from 74% to 86.3%. Finally, the survival rates showed that mice receiving the rPspA+PhtD formulation survived significantly longer (100%) than those receiving protein alone or PBS and exhibited the strongest clearance with a 2 log10 decrease in bacterial load in the blood 24h after challenge compared to the control group. In conclusion, the rPspA+PhtD formulation can be considered a promising bivalent serotype-independent vaccine candidate for protection against invasive pneumococcal infection in the future.
Case Report: Missing zinc finger domains: hemophagocytic lymphohistiocytosis in a GATA2 deficiency patient triggered by non-tuberculous mycobacteriosis
Authors: Huang Xin , Wu Bingxuan , Wu Di , Huang Xiaoming , Shen Min
Published: August 2023

Haploinsufficiency of GATA2, also known as GATA2 deficiency, leads to a wide spectrum of clinical manifestations. Here we described another 28-year-old man with a GATA2 variant who also suffered from hemophagocytic lymphohistiocytosis(HLH), who was finally diagnosed with HLH triggered by Mycobacterium avium bloodstream infection due to primary immunodeficiency. We reviewed GATA2 deficiency patients with HLH and found that GATA2 variants causing loss of zinc finger domains were associated with HLH, and erythema nodosa might be an accompanying symptom.
Neutrophil extracellular traps mediate deep vein thrombosis: from mechanism to therapy
Authors: Yao Mengting , Ma Jiacheng , Wu Dongwen , Fang Chucun , Wang Zilong , Guo Tianting , Mo Jianwen
Published: August 2023

Deep venous thrombosis (DVT) is a part of venous thromboembolism (VTE) that clinically manifests as swelling and pain in the lower limbs. The most serious clinical complication of DVT is pulmonary embolism (PE), which has a high mortality rate. To date, its underlying mechanisms are not fully understood, and patients usually present with clinical symptoms only after the formation of the thrombus. Thus, it is essential to understand the underlying mechanisms of deep vein thrombosis for an early diagnosis and treatment of DVT. In recent years, many studies have concluded that Neutrophil Extracellular Traps (NETs) are closely associated with DVT. These are released by neutrophils and, in addition to trapping pathogens, can mediate the formation of deep vein thrombi, thereby blocking blood vessels and leading to the development of disease. Therefore, this paper describes the occurrence and development of NETs and discusses the mechanism of action of NETs on deep vein thrombosis. It aims to provide a direction for improved diagnosis and treatment of deep vein thrombosis in the near future.
Based on disulfidptosis-related glycolytic genes to construct a signature for predicting prognosis and immune infiltration analysis of hepatocellular carcinoma
Authors: Wang Zhijian , Chen Xuenuo , Zhang Jia , Chen Xuanxin , Peng Jiayi , Huang Wenxiang
Published: August 2023

Background

Hepatocellular carcinoma (HCC) comprises several distinct molecular subtypes with varying prognostic implications. However, a comprehensive analysis of a prognostic signature for HCC based on molecular subtypes related to disulfidptosis and glycolysis, as well as associated metabolomics and the immune microenvironment, is yet to be fully explored.

Methods

Based on the differences in the expression of disulfide-related glycolytic genes (DRGGs), patients with HCC were divided into different subtypes by consensus clustering. Establish and verify a risk prognosis signature. Finally, the expression level of the key gene SLCO1B1 in the signature was evaluated using immunohistochemistry (IHC) and quantitative real-time PCR (qRT-PCR) in HCC. The association between this gene and immune cells was explored using multiplex immunofluorescence. The biological functions of the cell counting kit-8, wound healing, and colony formation assays were studied.

Results

Different subtypes of patients have specific clinicopathological features, prognosis and immune microenvironment. We identified seven valuable genes and constructed a risk-prognosis signature. Analysis of the risk score revealed that compared to the high-risk group, the low-risk group had a better prognosis, higher immune scores, and more abundant immune-related pathways, consistent with the tumor subtypes. Furthermore, IHC and qRT-PCR analyses showed decreased expression of SLCO1B1 in HCC tissues. Functional experiments revealed that SLCO1B1 overexpression inhibited the proliferation, migration, and invasion of HCC cells.

Conclusion

We developed a prognostic signature that can assist clinicians in predicting the overall survival of patients with HCC and provides a reference value for targeted therapy.
Factors impacting the benefits and pathogenicity of Th17 cells in the tumor microenvironment
Authors: Xing Jie , Man Changfeng , Liu Yingzhao , Zhang Zhengdong , Peng Huiyong
Published: August 2023

Tumor development is closely associated with a complex tumor microenvironment, which is composed of tumor cells, blood vessels, tumor stromal cells, infiltrating immune cells, and associated effector molecules. T helper type 17 (Th17) cells, which are a subset of CD4+ T cells and are renowned for their ability to combat bacterial and fungal infections and mediate inflammatory responses, exhibit context-dependent effector functions. Within the tumor microenvironment, different molecular signals regulate the proliferation, differentiation, metabolic reprogramming, and phenotypic conversion of Th17 cells. Consequently, Th17 cells exert dual effects on tumor progression and can promote or inhibit tumor growth. This review aimed to investigate the impact of various alterations in the tumor microenvironment on the antitumor and protumor effects of Th17 cells to provide valuable clues for the exploration of additional tumor immunotherapy strategies.
Integrated signaling and transcriptome analysis reveals Src family kinase individualities and novel pathways controlled by their constitutive activity
Authors: Koutras Nikolaos , Morfos Vasileios , Konnaris Kyriakos , Kouvela Adamantia , Shaukat Athanasios-Nasir , Stathopoulos Constantinos , Stamatopoulou Vassiliki , Nika Konstantina
Published: August 2023

The Src family kinases (SFKs) Lck and Lyn are crucial for lymphocyte development and function. Albeit tissue-restricted expression patterns the two kinases share common functions; the most pronounced one being the phosphorylation of ITAM motifs in the cytoplasmic tails of antigenic receptors. Lck is predominantly expressed in T lymphocytes; however, it can be ectopically found in B-1 cell subsets and numerous pathologies including acute and chronic B-cell leukemias. The exact impact of Lck on the B-cell signaling apparatus remains enigmatic and is followed by the long-lasting question of mechanisms granting selectivity among SFK members. In this work we sought to investigate the mechanistic basis of ectopic Lck function in B-cells and compare it to events elicited by the predominant B-cell SFK, Lyn. Our results reveal substrate promiscuity displayed by the two SFKs, which however, is buffered by their differential susceptibility toward regulatory mechanisms, revealing a so far unappreciated aspect of SFK member-specific fine-tuning. Furthermore, we show that Lck- and Lyn-generated signals suffice to induce transcriptome alterations, reminiscent of B-cell activation, in the absence of receptor/co-receptor engagement. Finally, our analyses revealed a yet unrecognized role of SFKs in tipping the balance of cellular stress responses, by promoting the onset of ER-phagy, an as yet completely uncharacterized process in B lymphocytes.