bluuebunny/crossref_metadata_2025 huggingface dataset:
Harnessing the human microbiome: Probiotic and prebiotic interventions to reduce hospital-acquired infections and enhance immunity
Authors: Aliu Olalekan Olatunji  , Janet Aderonke Olaboye  , Chukwudi Cosmos Maha  , Tolulope Olagoke Kolawole  , Samira Abdul
Published: July 2024

Hospital-acquired infections (HAIs) represent a significant burden on healthcare systems, leading to increased morbidity, mortality, and healthcare costs. Recent advancements in microbiome research have highlighted the potential of probiotic and prebiotic interventions to mitigate HAIs and bolster immunity. This review explores the role of the human microbiome in health and disease, focusing on the promising strategies of utilizing probiotics and prebiotics to reduce HAIs. Probiotics, comprising live beneficial bacteria, can restore and maintain a balanced gut microbiota, potentially outcompeting pathogenic organisms and enhancing host immune responses. Prebiotics, however, are non-digestible food ingredients that selectively stimulate the growth and activity of beneficial bacteria in the gut. The synergistic effects of probiotics and prebiotics, known as symbiotic, offer an even greater potential for clinical application. Numerous studies have demonstrated the efficacy of specific probiotic strains, such as Lactobacillus and Bifidobacterium, in preventing infections and modulating immune functions. Furthermore, prebiotics like fructo-oligosaccharides (FOS) and galacto-oligosaccharides (GOS) have shown to enhance the growth of probiotic bacteria, thus providing a twofold protective mechanism. The integration of these interventions into clinical practice could revolutionize the prevention and management of HAIs, reducing the reliance on antibiotics and mitigating the risk of antimicrobial resistance. However, challenges such as strain-specific effects, dosage optimization, and individual variability need to be addressed through rigorous clinical trials. This review underscores the need for further research and clinical validation to harness the full potential of the human microbiome in combating HAIs and enhancing patient outcomes through probiotic and prebiotic interventions.
Keywords:  Human Microbiome, HAIs, Immunity.
Ledare
Authors: Svenungsson Jayne
Published: July 2024

N/A
Teresia Derlén & Frida Mannerfelt (red.), Som spridda sädeskornen: Perspektiv på nattvardens levda teologi
Authors: Lazić Pedersen Sofija
Published: July 2024

N/A
TECNOLOGIA CAR-T NO MANEJO DA LEUCEMIA LINFOBLÁSTICA AGUDA DE CÉLULAS T: DESAFIOS E PERSPECTIVAS CLÍNICAS
Authors: Casagrande Lucas Zuccolotto , Yenikomshian Fernanda Paiva , Medeiros Gustavo Angelo , Ribeiro Neta Julia Dias , Grespan Leonardo Costa , Hilgert Leonardo Reinert
Published: July 2024

A leucemia linfoblástica aguda de células T (LLA-T) é um tipo de neoplasia maligna que afeta a linhagem linfocítica T, e é um dos mais comuns na pediatria oncológica. Consiste na proliferação descontrolada de células progenitoras hematopoiéticas e pode se tornar um tumor bastante agressivo em alguns casos. Entretanto, a utilização da técnica de células CAR-T pode frear a enfermidade e levar à remissão pacientes que não reagiram aos tratamentos convencionais - como quimioterapia e transplante de medula. O presente trabalho busca apresentar a utilização da técnica CAR-T no tratamento da LLA-T em pacientes refratários aos métodos convencionais. Para isso, realizou-se uma revisão da literatura com artigos internacionais datados de 1995 a 2022 encontrados nas plataformas PubMed, MedLine e Scielo. A busca nessas plataformas utilizou-se dos termos “LLA-T”, “LLA-B”, “CAR-T”, “remissão”, “CRISPR” e “edição de genes”, em português ou inglês. Dentre os principais resultados, foi possível observar que a LLA é uma enfermidade que acomete majoritariamente crianças, caracteriza-se por uma abundância de células linfóides imaturas na medula óssea e no sangue, as quais são geradas por uma disfunção genética que desencadeia uma proliferação celular desenfreada e dificulta a produção fisiológica de leucócitos, eritrócitos e plaquetas. O tratamento levou à remissão da LLA-T em uma adolescente no Reino Unido. Foram utilizados linfócitos T de um doador saudável, os quais foram modificados geneticamente para combater a leucemia. Com isso, as células T modificadas combateram os linfócitos tumorais e a paciente atingiu a remissão. Dessa maneira, conclui-se que, uma vez que a utilização da técnica de edição de bases levou a remissão completa da leucemia na paciente, fica claro que essa demonstra ser uma tecnologia com implicações positivas diversas; nesse aspecto, estimula-se o desenvolvimento de mais pesquisas na área que visem aperfeiçoar e possivelmente expandir o uso da tecnologia utilizada para outros tipos de leucemia.
PERSPECTIVAS SOBRE O AVANÇO DA EDUCAÇÃO A DISTÂNCIA DURANTE A PANDEMIA
Authors: Costa Veronice Oliveira da , Pinho Alexandra Moreno
Published: July 2024

O presente artigo tem como objetivo compreender como a Educação a Distância (EaD) se expandiu significativamente no período pós pandemico, consolidando-se como uma modalidade que atende, em massa, estudantes de nível superior. A partir de uma revisão bibliográfica, foi possível identificar alguns fatores que contribuem para os questionamentos levantados em torno das vantagens e desvantagens do EaD. Outro fator observado, foram as situações contextuais que dificultam a participação ativa dos estudantes, impedindo-lhes de obterem êxito nas avaliações. Constata-se, também, um aumento na evasão e na inadimplência destes alunos. A fiscalização em torno dos pólos de educação a distância diminuiu desde 2017, o que favorece a redução dos níveis de qualidade do ensino. Questões como  condições sociais do estudante, qualificação dos profissionais e materias pedagógicos disponibilizados são fatores que ainda comprometem a qualidade destes cursos no país.
Critical contribution of chemically diverse carbonyl molecules to the oxidative potential of atmospheric aerosols
Authors: Li Feifei , Tang Shanshan , Lv Jitao , Yu Shiyang , Sun Xu , Cao Dong , Wang Yawei , Jiang Guibin
Published: July 2024

Abstract. Carbonyls have an important effect on atmospheric chemistry and human health because of their high electrophilicity. Here, high-throughput screening of carbonyl molecules in complex aerosol samples was achieved by combining targeted derivatization with non-targeted analysis using Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS). Results showed that water-soluble organic matter (WSOM) in PM2.5 contains a large variety of carbonyls (5147 in total), accounting for 17.6 % of all identified organic molecules. Compared with non-carbonyl molecules, carbonyl molecules are more abundant in winter than in summer and have unique molecular composition and chemical parameters. For the first time, a significant positive correlation was found between the abundance of carbonyl molecules and the dithiothreitol (DTT) activities of WSOM, and the elimination of the carbonyl group remarkably reduced the DTT activities, highlighting the pivotal role of carbonyls in determining the oxidative potential (OP) of organic aerosol. Among various molecules, oxidized aromatic compounds containing the carbonyl group produced in winter contributed more to the enhancement of DTT activity, which could be used as potential markers of atmospheric oxidative stress. This study improves our understanding of the chemical diversity and environmental health effects of atmospheric carbonyls, emphasizing the need for targeted strategies to mitigate the health risks associated with carbonyl-rich aerosols.
Large contributions of soil emissions to the atmospheric nitrogen budget and their impacts on air quality and temperature rise in North China
Authors: Sha Tong , Yang Siyu , Chen Qingcai , Li Liangqing , Ma Xiaoyan , Zhang Yan-Lin , Feng Zhaozhong , Boersma K. Folkert , Wang Jun
Published: July 2024

Abstract. Soil emissions of nitrogen compounds, including NO and HONO, play a significant role in the atmospheric nitrogen budget. However, HONO has been overlooked in previous research on soil reactive nitrogen (Nr) emissions and their impacts on air quality in China. This study estimates soil NOx and soil HONO emissions (SNOx and SHONO) in North China during July 2018 using an updated soil Nr emissions scheme in a chemical transport model, Unified Inputs (initial and boundary conditions) for Weather Research and Forecasting coupled with Chemistry (UI-WRF-Chem). The effects of soil Nr emissions on O3 pollution, air quality and temperature rise are also studied, with a focus on two key regions, Beijing–Tianjin–Hebei (BTH) and the Fenwei Plain (FWP), known for high soil Nr and anthropogenic emissions. We find that the flux of SNOx is nearly double that of SHONO. The monthly contributions of SNOx and SHONO account, respectively, for 37.3 % and 13.5 % of anthropogenic NOx emissions in BTH and for 29.2 % and 19.2 % in the FWP during July 2018. Soil Nr emissions have a significant impact on surface O3 and nitrate, exceeding SNOx or SHONO effects alone. On average, soil Nr emissions increase maximum daily 8 h (MDA8) O3 by 16.9 % and nitrate concentrations by 42.4 % in BTH, and they increase MDA8 O3 by 17.2 % and nitrate concentrations by 42.7 % in the FWP. Reducing anthropogenic NOx emissions leads to a more substantial suppressive effect of soil Nr emissions on O3 mitigation, particularly in BTH. Soil Nr emissions, through their role as precursors for secondary inorganic aerosols, can result in a slower increase rate of surface air temperature in future emissions reduction scenarios. This study suggests that mitigating O3 pollution and addressing climate change in China should consider the role of soil Nr emissions and their regional differences.
Distributions of in situ parameters, dissolved (in)organic carbon, and nutrients in the water column and pore waters of Arctic fjords (western Spitsbergen) during a melting season
Authors: Saghravani Seyed Reza , Böttcher Michael Ernst , Hong Wei-Li , Kuliński Karol , Lepland Aivo , Sen Arunima , Szymczycha Beata
Published: July 2024

Abstract. A nutrient distribution, such as that of phosphate (PO43-), ammonium (NH4+), nitrate (NO3-), dissolved silica (Si), total dissolved nitrogen (TN), and dissolved organic nitrogen (DON), together with dissolved organic carbon (DOC) and inorganic carbon (DIC), was investigated during a high-melting season in 2021 in the western Spitsbergen fjords (Hornsund, Isfjorden, Kongsfjorden, and Krossfjorden). Both the water column and the pore water were investigated for nutrients and dissolved carbon distribution and gradients. The water column concentrations of most measured parameters, such as PO43-, NH4+, NO3-, Si, and DIC, showed significant changes among fjords and water masses. In addition, pore water gradients of PO43-, NH4+, NO3-, Si, DIC, and DOC revealed significant variability between fjords and are likely substantial sources of the investigated elements for the water column. The reported dataset reflects differences in hydrography and biogeochemical ecosystem functions of the investigated western Spitsbergen fjords and may form the base for further modeling of physical oceanographic and biogeochemical processes within these fjords. All data discussed in this communication are stored in the Zenodo online repository at https://doi.org/10.5281/zenodo.11237340 (Szymczycha et al., 2024).
ZJU-AERO V0.5: an Accurate and Efficient Radar Operator designed for CMA-GFS/MESO with the capability to simulate non-spherical hydrometeors
Authors: Xie Hejun , Bi Lei , Han Wei
Published: July 2024

Abstract. In this study, we present a new forward polarimetric radar operator called the Accurate and Efficient Radar Operator designed by ZheJiang University (ZJU-AERO). This operator was designed to interface with the numerical weather prediction (NWP) model of the global forecast system/regional mesoscale model of the China Meteorological Administration (CMA-GFS/MESO). The main objective of developing this observation operator was to assimilate observations from the precipitation measurement radar (PMR). It is also capable of simulating the ground-based radar's polarimetric radar variables, excluding the Doppler variables such as radial velocity and spectrum width. To calculate the hydrometeor optical properties of ZJU-AERO, we utilize the invariant-imbedding T-matrix (IITM) method, which can handle non-spherical and inhomogeneous hydrometeor particles in the atmosphere. The optical database of ZJU-AERO was designed with a multi-layered architecture to ensure the flexibility in hydrometeor morphology and orientation specifications while maintaining operational efficiency. Specifically, three levels of databases are created that store the single-scattering properties for different shapes at discrete sizes for various fixed orientations, integrated single-scattering properties over shapes and orientations, and bulk-scattering properties incorporating the size average, respectively. In this work, we elaborate on the design concepts, physical basis, and hydrometeor specifications of ZJU-AERO. Additionally, we present a case study demonstrating the application of ZJU-AERO in simulating the radar observations of Typhoon Haishen.
Flood drivers and trends: a case study of the Geul River catchment (the Netherlands) over the past half century
Authors: Tsiokanos Athanasios , Rutten Martine , van der Ent Ruud J. , Uijlenhoet Remko
Published: July 2024

Abstract. In July 2021, extreme precipitation caused devastating flooding in Germany, Belgium and the Netherlands, particularly in the Geul River catchment. Such precipitation extremes had not been previously recorded and were not expected to occur in summer. This contributed to poor flood forecasting and, hence, extensive damage. Climate change was mentioned as a potential explanation for these unprecedented events. However, before such a statement can be made, we need a better understanding of the drivers of floods in the Geul and their long-term variability, which are poorly understood and have not been recently examined. In this paper, we use an event-based approach to identify the dominant flood drivers in the Geul. We also employ (1) a multi-temporal trend analysis to investigate their temporal variability and (2) a novel methodology to detect the dominant direction of any trend. Results suggest that extreme 24 h precipitation alone is typically insufficient to cause floods. The joint probability of extreme and prolonged rainfall combined with wet initial conditions (compound event) determines the chances of flooding. Flood-producing precipitation shows a consistent increase in the winter half-year, a period in which more than 70 % of extremely high flows have historically occurred. While no consistent trend patterns are evident in the majority of precipitation and extreme flow trends in the summer half-year, an increasing direction is visible in the recent past.
The effect of reward value on the performance of long-tailed macaques (Macaca fascicularis) in a delay-of-gratification exchange task
Authors: Stolla Judit J. , Keupp Stefanie
Published: July 2024

Abstract. In the context of a global research initiative called ManyPrimates, scientists from around the world collaborated to collect data aimed at comparing the ability of various primate species to delay gratification. Our contribution to this project involved collecting data from long-tailed macaques (Macaca fascicularis). Our findings indicated that these macaques rarely opted to exchange a given food item for a larger food reward at a later time. However, we suspected that the experimental protocol might not accurately capture the macaques' actual capacity to delay gratification. Specifically, possessing a highly desirable food item might discourage the monkeys' participation in food exchange and delay-of-gratification tasks. To explore whether this potential mental distraction was affecting their performance, we conducted experiments on six long-tailed macaques under two different conditions. In these conditions, we examined how the value of the exchange item influenced the frequency of exchanges. In one condition, subjects received a high-value food item, while in the other, they received a low-value food item, both of which could be exchanged for three high-value food items. When we reduced the value of the exchange item, the long-tailed macaques displayed significantly improved abilities to delay gratification within the exchange task. These findings strongly suggest that the possession of a high-value item significantly contributed to the low performance of these monkeys in the original delay-of-gratification exchange protocol and raise the question of which performance reflects the monkeys' underlying delay-of-gratification competence more adequately.
Abundance, detection and conservation of the threatened Julia Creek dunnart (Sminthopsis douglasi) in Bladensburg National Park (Queensland, Australia)
Authors:   , Bakker Alice
Published: July 2024

The threatened Julia Creek dunnart is a small carnivorous marsupial found in the Mitchell Grasslands of central western Queensland. There is very little research on this species. The objective of the present study was to better understand the status of Julia Creek dunnarts at Bladensburg National Park, and also to assess best-practice detection techniques. Several detection techniques were assessed, including live-capture traps, camera traps and a trial of thermal binoculars. Results to date suggest live-trapping is the most successful detection method of those trialled for surveying Julia Creek dunnarts and that the population at Bladensburg is presently stable.
ANALISIS PRODUKSI DAN PENDAPATAN USAHATANI PADI SAWAH DI KELURAHAN SISIPAN KECAMATAN BATUI KABUPATEN BANGGAI
Authors: Bolong Moh. Wahyudi J. ,   Program Studi Agribisnis Fakultas Pertanian Universitas Tompotika Luwuk, Puspapratiwi Dian , Tatu Irsan Z , Enteding Trianto ,   Program Studi Agribisnis Fakultas Pertanian Universitas Tompotika Luwuk,   Program Studi Agribisnis Fakultas Pertanian Universitas Tompotika Luwuk,   Program Studi Agribisnis Fakultas Pertanian Universitas Tompotika Luwuk
Published: July 2024

The main activities and main sources of income of the community, especially people in rural areas, are still dependent on the agricultural sector. An agricultural commodity that is expected to move positively in terms of increasing production and income is rice. The purpose of this study is to find out what factors affect the production of paddy rice farming in Sisipan Village, Batui District. Knowing how much production and income of paddy rice farming is in Sisipan Village, Batui District. The results obtained from this study are the Use of Production Inputs and Production Factors studied, 5 variables affect paddy rice production, namely land area (X1), seed use (X2), fertilizer use (X3), pesticide use (X4), and labor use (X5). Based on the income analysis, the average respondent farmer revenue rate was Rp. 24,022,857.14 with costs incurred by respondent farmers for the production process of paddy rice farming business on average Rp. 4,004,452.38, so that the average income of paddy rice farming by respondent farmers was Rp. 20,018,404.76.
PENGARUH MULSA DAN PUPUK KANDANG AYAM TERHADAP PERTUMBUHAN DAN HASIL TANAMAN MENTIMUN
Authors: loilainge nurhalizah ,   Program Studi Agroteknologi Fakultas Pertanian Universitas Tompotika Luwuk, Yatim Hertasning , Setiawan Wawan ,   Program Studi Agroteknologi Fakultas Pertanian Universitas Tompotika Luwuk,   Program Studi Agroteknologi Fakultas Pertanian Universitas Tompotika Luwuk
Published: July 2024

Cucumber is one of the horticultural crops that is widely cultivated by farmers in our country, Indonesia. The purpose of this study was to determine the growth and yield of cucumber plants by applying plastic mulch and applying chicken manure. This research was carried out from June to September 2021 in Sisipan Village, Batui District, Banggai Regency. This study used a factorial randomized block design (RBD) consisting of 2 factors. Parameters observed in this study included plant height (7, 14, 21, and 28 DAP), number of leaves (7, 14, 21 and 28 DAP), fruit length (first and second harvests), fruit diameter (first and second harvests) and fruit weight (first and second harvest). The research data were analyzed using the F test of variance analysis and continued with the Honest Significant Difference Test (BNJ) at the 5% level. The results of the study had a significant effect on the plastic mulch treatment on plant height at 7 HST, 14 HST and 21 HST. Number of leaves at the age of 7 HST, 14 HST, 21 HST and 28 HST. The length of the first harvest fruit. The diameter of the fruit of the first harvest and the second harvest. The weight of the first harvest fruit. The application of chicken manure had a significant effect on the length of the first harvest fruit and the weight of the first harvest fruit on cucumber plants.
PENGARUH KOMPOS DAUN GAMAL TERHADAP PERTUMBUHAN DAN HASIL BEBERAPA VARIETAS PADI SAWAH
Authors: Ardiasa I Komang ,   Program Studi Agroteknologi Fakultas Pertanian Universitas Tompotika Luwuk, Djamaluddin Ismail , Mambuhu Nurmasyitah ,   Program Studi Agribisnis Fakultas Pertanian Universitas Tompotika Luwuk,   Dinas Ketahanan Pangan Kabupaten Banggai
Published: July 2024

Gamal leaf compost is the result of the process of decomposing organic matter that is decomposed by microorganisms that can produce nutrients needed by plants. The use of compost can also reduce and compensate for the continuous use of chemical fertilizers by farmers. The selection of high-yielding varieties is also the most important thing in increasing rice yields. This study aims to determine the effect of gamal leaf compost on the growth and yield of several rice varieties. The research was conducted on rice fields in Karya Makmur Village, West Toili District, Banggai from July to November 2021. This study used a randomized group design consisting of 2 treatment factors. The first factor in giving gamal leaf compost consists of 4 levels, namely P0 = 0 kg / plot as the ruler, P1 = 0.8 kg / plot, P2 = 1.6 kg / plot, P3 = 2.4 kg / plot. The second factor of using varieties consists of 3 levels, namely V1 = Ciherang, V2 = Cisantana, V3 = Sintanur. The results of fingerprint analysis showed that gamal leaf compost treatment had a real and very real effect on the growth and yield of rice fields, while the use of varieties had a real and very real effect on growth and had no effect on rice field yields. The interaction between the two treatments had a significant effect on plant height of 3-4 MST. The best dose for plant height parameters, number of productive tillers, panicle length, grain weight per plot with a dose of gamal leaf compost with a dose of 2.4 kg / plot, while in P2 treatment with a dose of 1.6 kg / plot gamal leaf compost is the best dose on the parameters of the number of tillers.
PENGARUH FAKTOR SOSIAL EKONOMI TERHADAP PENDAPATAN KOMODITI PALA DI DESA MAMPING KECAMATAN BALANTAK KABUPATEN BANGGAI
Authors: Enteding Trianto ,   Program Studi Agribisnis Fakultas Pertanian Universitas Tompotika Luwuk, Marowa Anita Purnama , Rustiawati Yuni ,   Program Studi Agribisnis Fakultas Pertanian Universitas Tompotika Luwuk,   Program Studi Agribisnis Fakultas Pertanian Universitas Tompotika Luwuk
Published: July 2024

Plantation crop commodities are quite strategic trade crops in Banggai Regency, so this study aims to determine the influence and relationship of socioeconomic factors on the income of nutmeg farmers in Mamping Village, Balantak District, Banggai Regency. This research has been carried out in Mamping Village, Balantak District, Banggai Regency, from June to August 2022, using quantitative analysis methods, namely income and regression approaches. The results showed the use of land area (X1=0.838) and age (X2=0.047) factors that had a positive influence on income (Y) while the rest (X3= -0.088, X4= -0.049, X5= -0.089) is negative. that is, those that are between the values of regression coefficients 1 and 0. This explains that every addition of X1 and X2 variables by 1% will increase the income of nutmeg farmers by 0.838 and 0.047 respectivelyProduction and Production Factors studied there are 4 variables that affect nutmeg production, namely education (X1), age (X2), family dependents (X3), farming experience (X4). Based on the results of the study, the relationship between socioeconomic factors (land area, age, education level, farming experience, family dependents) on the income of nutmeg farmers in Mamping Village, Balantak District, Banggai Regency correlated obtained the results of nutmeg farming research in Mamping Village of 0.87 showed that variable X has a very strong relationship with nutmeg farming income.
Computation of Nash Equilibria of Two-Person m x n Games
Authors: Wang Albert
Published: July 2024

In this paper, the author discusses the computation of Nash equilibria of two-person m x n games with Maple, where m and n are positive integers greater than 1. The powerful Maple NLPSolve package is used to solve a nonlinear programming problem which leads to Nash equilibria of the game.
L^infinity-norm computation for linear time-invariant systems depending on parameters
Authors: Quadrat Alban , Rouillier Fabrice , Younes Grace
Published: July 2024

This paper focuses on representing the L∞-norm of finite-dimensional linear time-invariant systems with parameter-dependent coefficients. Previous studies tackled the problem in a non-parametric scenario by simplifying it to finding the maximum y-projection of real solutions (x, y) of a system of the form Sigma = {P=0,  dP/dx=0}, where P is in Z[x, y]. To solve this problem, standard computer algebra methods were employed and analyzed.
In this paper, we extend our approach to address the parametric case. We aim to represent the ````"maximal" y-projection of real solutions of Sigma as a function of the given parameters.To accomplish this, we utilize cylindrical algebraic decomposition. This method allows us to determine the desired value as a function of the parameters within specific regions of parameter space.
The Lagrangian formalism Application
Authors: Si Lakhal Bahia
Published: July 2024

The Frahm damper, also called a tuned mass damper (TMD), is a device used to attenuate the vibrations of a mechanical system. It consists of an oscillating damped mass which forms the auxilliary system that is attached to a particular location of a structure (the main system) to minimise its mechanical vibrations . The TMD's are very useful in engineering applications as they can prevent damage or outright structural failure. They are included, for instance, in floor systems, balconies, monumental staircases and pedestrian bridges. They are also frequently used in power transmission and cars. When designing a TMD, the key factor is the tuning of some of parameters to achieve the desired performance. We aim to study the optimization of the TMDs. For that purpose, the Lagrangian approach to deriving the equations of motion is used. We define the dynamical amplification factor that will be used to study the optimization of the TMD. Some commands of Maple software are used to achieve this goal.
Overview of Aggressiveness in Early Adolescents Who Play Online Games
Authors: Koanda Naftalen , Rahayu Puji , Zainuddin Nurul Inayah
Published: July 2024

The purpose of this study is to present a clear picture of aggressiveness among early adolescent online gamers. The research method used is qualitative research with a descriptive approach. The data for this study came from interviews, observations, and literature review. The findings show that violent online games can increase aggression in early adolescents. Physical aggression, verbal aggression, and behavior that damages other people's property are examples of aggressive behavior.
A Scoping Review on the Impacts of Electronic Health Record Systems on Healthcare Delivery
Authors: Razzano Anthony Vincent
Published: July 2024

Background: Electronic health record (EHR) systems have evolved significantly since their introduction in the early 1960s, replacing traditional paper-based medical records with computerized storage of patient health information. The adoption of EHR systems has expanded across various healthcare settings due to advancements in technology, necessitating systems that offer diverse functionalities and seamless integration capabilities. As healthcare technology continues to progress, EHR systems must adapt by incorporating additional features such as predictive algorithms and clinical decision support. However, the widespread use of EHR systems has also led to challenges in interoperability, prompting the development of standards.
Methodology: This scoping review uses the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews checklist to systematically search and select relevant literature from PubMed. A research inquiry included full-text studies published in 2023, utilizing keywords "electronic health record system," "quality care," "patient safety," "clinical outcomes," and "hospital." Initial screening involved reviewing abstracts and titles, followed by a full-text review of 5 selected articles. Three articles that met eligibility criteria were synthesized to explore the impact of EHR systems on healthcare delivery.
Conclusion: This study draws conclusions based on the evidence synthesized, which highlights the critical role of standardized EHR systems in improving hospital patient outcomes through enhanced safety, care coordination, and data quality. The integration of advanced functionalities like clinical decision support systems, SNOMED CT, and closed-loop electronic medication management systems has demonstrated significant benefits in reducing errors, streamlining workflows, and supporting informed decision-making. Despite these advancements, challenges such as scalability, alert fatigue, and implementation costs persist, requiring ongoing collaboration among stakeholders and continuous research efforts. Future research on harnessing the capabilities of artificial intelligence and machine learning to further enhance EHR systems and address remaining barriers can ultimately optimize patient care and safety in hospital setting.

Key words: electronic health record, information system, information technology management
Determinants of Earning Response Coefficients (ERC) in Listed Deposit Money Banks in Nigeria
Authors: M. O. Oladejo , E. A. Alagbe , H. Y. Nasiru
Published: July 2024

This paper is set to examine the determinants of earnings response coefficients in Nigerian deposit money banks. Specifically, it examined how a bank’s level of non-performing loans, beta as a measure of market risk, earnings persistence, banks’ growth, and size influence shareholders, investors, and other market participants' investment decisions. An ex-post facto research design was adopted for the study, with secondary data collected from ten deposit money listed on the Nigerian Exchange Group from 2010-2022. Panel Least Square, Breusch Pagan, and LM and Pesaran Cross-Sectional Dependence tests were conducted to enhance the robustness of the analysis. Findings from the analysis revealed that market beta, non-performing loans, banks’ growth, and size were the major determinants of the earning response coefficient in selected listed deposit money banks in Nigeria. Consequently, the study recommends that the management of banks should focus on actively managing market risk, optimising bank size, and addressing non-performing loans to enhance market confidence and positively influence earnings response. Additionally, attention should be given to strategies promoting sustainable growth that can contribute to favourable market perceptions of earnings declared by banks.
New Entrants in the Pandemic Era: An Empirical Study on Factors Affecting Start-Up Businesses in The Cities of the Philippines
Authors: Jamer Mary Matthew N. , Purisima Aicille , Olvido John Robert M. , Broqueza Mara R. , Reyes Joseph C.
Published: July 2024

The study’s purpose was to assess the factors influencing the establishment of startup businesses in Philippine Cities during the pandemic. To achieve this, a quantitative method employing a causal explanatory research design was utilized. The study relied on data from the cities and municipalities competitive index (CMCI), which were then analyzed using the Pearson Correlation Coefficient and Multiple linear regression. The findings of the study revealed a positive and significant relationship between newly approved businesses and four variables: the number of banks, the presence of a business-one-stop-shop (boss) operating throughout the year, the availability of broadband services, and the presence of transportation options. These factors were shown to have a significant impact on the establishment of startup businesses in Philippine cities. Regression analysis identified local inflation rate, number of banks, and transportation options as significant predictors of startup businesses in Philippine cities. A 1% increase in the inflation rate resulted in a 69.286 decrease in startups. Based on these factors, the study concluded that launching a business during the pandemic was found to be exceedingly challenging, with existing startups facing greater vulnerability to COVID-19 shocks compared to established businesses. This study highlighted the challenges faced by startups during the pandemic and emphasized the importance of factors like financial access, streamlined registration processes, reliable internet, transportation infrastructure, and inflation rates. Understanding these factors is vital for policymakers and entrepreneurs striving to foster startup establishment and growth in Philippine cities during challenging times.
As aprendizagens significativas integradas às tecnologias digitais para o Ensino de Inglês: uma Revisão Sistemática da Literatura
Authors: Martins Antonia Andressa Ramos , Moreira Sara Cavalcante , Barros Filho Edgar Marçal de , Lima Luciana de
Published: July 2024

Aprendizagem significativa é um conceito da teoria de aprendizagem de David Ausubel. Valoriza aquilo que faz sentido para o aluno e o quanto a informação deve interagir com os conceitos de sua estrutura cognitiva. O artigo apresenta uma Revisão Sistemática da Literatura sobre a mediação dessa aprendizagem com uso das tecnologias digitais nas aulas de Inglês na Educação Básica. Realizou-se uma análise bibliográfica nas publicações do Google Acadêmico cujos resultados consideraram publicações de 2015 a 2021, em português e inglês. Identificaram-se muitos benefícios das tecnologias digitais para a mediação das aprendizagens significativas no Ensino de Inglês em sala de aula, seja ela física ou virtual, como: maior engajamento dos alunos com a ludicidade das atividades mediadas pelas tecnologias digitais; estudantes mais motivados e estimulados a dialogar; maior autonomia e participação ativa no processo de ensino-aprendizagem; metodologias ativas que colocam o aluno no centro do processo de construção dos seus conhecimentos e o desenvolvimento cognitivo a partir da mediação da aprendizagem significativa. Quanto aos fatores e às motivações para a mediação de uma aprendizagem significativa no Ensino da Língua Inglesa com o uso das tecnologias digitais, constatou-se a valorização dos conhecimentos prévios e facilitação para introduzir novos conteúdos assim como possibilidades aos educandos para contato com projeções de sua realidade e a concretização da aprendizagem através de participação e cooperação dos alunos com maior confiança para integrar tecnologias digitais na mediação de aprendizagens mais contextualizadas e personalizadas em conformidade ao nível e ritmo do educando. Apesar de todos os benefícios, verificou-se um quantitativo pequeno de pesquisas sobre aplicabilidade de ferramentas digitais como mediadoras de aprendizagens significativas no Ensino de Inglês.
Bacterial contamination of intensive care units, Sana’a City, 2019, Yemen
Authors: Abdullah Al Amad Mohammed ,   Yemen Field Epidemiology Training Program, Ministry of Public Health and Population, Yemen.
Published: July 2024

Background: Contamination of intensive care unit (ICU) is one of nosocomial infection risks that increase the costs of care and predispose ICU patients to higher mortality rates. The aims are to identify bacterial contamination and determine the pathogen isolates from the ICUs of Sana’a city hospitals.
A case report of hyperammonemic encephalopathy induced by high-dose continuous infusion of 5-fluorouracil in a patient with rectal cancer
Authors: Jin Song ,   Department of Oncology, Wenzhou TCM Hospital of Zhejiang Chinese Medical University, Wenzhou, Zhejiang 325000, China., Dai Chaoming , Cai Wenpin , Bai Wei , Zhang Jizhou ,   Department of Infectious Diseases, Wenzhou TCM Hospital of Zhejiang Chinese Medical University, Wenzhou, Zhejiang 325000, China.,   Department of Laboratory Medicine, Wenzhou TCM Hospital of Zhejiang Chinese Medical University, Wenzhou, Zhejiang 325000, China.,   Department of Laboratory Medicine, Wenzhou TCM Hospital of Zhejiang Chinese Medical University, Wenzhou, Zhejiang 325000, China.,   Department of Oncology, Wenzhou TCM Hospital of Zhejiang Chinese Medical University, Wenzhou, Zhejiang 325000, China.
Published: July 2024

Background: Hyperammonemia caused by high-dose infusion of 5-fluorouracil (5-Fu) is a rare adverse reaction in patients with rectal cancer. There are very few reports of hyperammonemia caused by 5-Fu in domestic and foreign literatures, however, deficiency of DihydroPyrimidine Dehydrogenase (DPD) and the influence of 5-Fu metabolites may be the pathogenic mechanisms of encephalopathy. Muscle loss, renal insufficiency and infection also has played an important role in the occurrence.
Role of the lncRNA HOX antisense intergenic RNA myeloid 1 in Cancer: A Review
Authors: Jing Yipei ,   Department of Clinical Laboratory, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China., Wang Shasha , Guo Ye , Qin Xuzhen , Li Yongzhe ,   Department of Clinical Laboratory, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.,   Department of Clinical Laboratory, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.,   Department of Clinical Laboratory, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.,   Department of Clinical Laboratory, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Published: July 2024

Long noncoding RNAs (lncRNAs) have emerged as a new family of master regulators of cancer. The HOXA transcript antisense RNA myeloid-specific 1 (HOTAIRM1) located in the HOXA gene cluster was first discovered in acute promyelocytic leukemia. Increasing evidence have showed that HOTAIRM1 is involved in diverse cancer. It regulates tumor proliferation, invasion, and migration via various mechanisms and is related to the clinicopathological characteristics of tumor patients. This article reviews its expression, function, and molecular mechanism in various malignant tumors and future challenges for the diagnosis and treatment of cancers through HOTAIRM1.
Cataract and Fahr syndrome: A case report
Authors: K Amine ,   University Mohammed V Rabat, Morocco., S Hassina , N Tebbay , L Robbana , Y Akannour , L Serghini , E Abdellah ,   University Mohammed V Rabat, Morocco.,   University Mohammed V Rabat, Morocco.,   University Mohammed V Rabat, Morocco.,   University Mohammed V Rabat, Morocco.,   University Mohammed V Rabat, Morocco.,   University Mohammed V Rabat, Morocco.
Published: July 2024

Introduction: Fahr syndrome is a rare neurological disorder associated with abnormal calcium deposits in the brain. Cataract is a rare but potentially disabling complication of Fahr syndrome. Case report: We report a case of bilateral posterior subcapsular cataract in a patient with Fahr syndrome secondary to primary hyperparathyroidism. The patient underwent phacoemulsification with implantation of an artificial lens, which improved his visual acuity and quality of life. Discussion: Management of this association requires a multidisciplinary approach involving ophthalmologists, neurologists, endocrinologists and biologists. Further studies are needed to better understand the mechanisms, frequency, risk factors, screening, diagnosis and treatment of cataract in patients with Fahr syndrome. Conclusion: Cataract is a rare complication of Fahr’s syndrome, requiring multidisciplinary management and further study. Phacoemulsification improves vision and quality of life in patients with this association.
Acral ulcerations: An unusual presentation of carpal tunnel syndrome
Authors: Escolà Helena ,   Department of Dermatology, Hospital del Mar-Sea Institute of Medical Research, Barcelona, Spain,   Department of Medicine, Autonomous University of Barcelona (UAB), Barcelona, Spain.
Published: July 2024

A 92 year-old woman with history of carpal tunnel release ten years ago, consulted for 1-year history of painless subungual ulcers on the second and third fingers of the right hand (Figure 1). Physical examination also showed a short distant phalanx on the second right finger. No sclerodactyly, telangiectasias or calcifications were present. Capillaroscopy and blood test showed no abnormalities. A biopsy disclosed epidermal ulceration with mild chronic inflammation without signs of vasculitis or thrombosis. Hand X-rays revealed bone resorption in the distal phalanx of the right index finger (Figure 2). An electroneuromyography disclosed severe median nerve damage. A diagnosis of an ulcerative variant of Carpal Tunnel Syndrome was made and the patient was referred to the traumatologist for a newly surgical decompression of the median nerve.
Performance Evaluation of SAPFs Using Space Vector-Based HCC Under Various Loading Conditions
Authors: Rachana J. Patel
Published: July 2024

In this research paper, we present a novel space vector-based hysteresis current control (HCC) scheme for standard two-level voltage source inverter (VSI) shunt active power filters (SAPFs). The performance of the SAPF is evaluated under three loading scenarios: steady-state, transient, and unbalanced conditions. These evaluations focus on the SAPF's effectiveness in reducing the total harmonic distortion (THD) in the source current. The simulations are conducted using PSIM software, which includes a special dynamic link library (DLL) block. A fast Fourier transform (FFT) algorithm is utilized to generate the harmonic current components as a reference signal. The compensating current injected by the SAPF is controlled by gate pulses applied to the switching devices of each leg, determined by the logic behind the novel space vector-based HCC scheme.
The angiogenic growth of cities
Authors: Manoli Gabriele
Published: July 2024

Describing the space–time evolution of urban population is a fundamental challenge in the science of cities, yet a complete theoretical treatment of the underlying dynamics is still missing. Here, we first reconstruct the evolution of London (UK) over 180 years and show that urban growth consists of an initial phase of diffusion-limited growth, followed by the development of the railway transport network and a consequential shift from central to suburban living. Such dynamics—which are analogous to angiogenesis in biological systems—can be described by a minimalist reaction–diffusion model coupled with economic constraints and an adaptive transport network. We then test the generality of our approach by reproducing the evolution of Sydney, Australia, from 1851 to 2011. We show that the rail system coevolves with urban population, displaying hierarchical characteristics that remain constant over time unless large-scale interventions are put in place to alter the modes of transport. These results demonstrate that transport schemes are first-order controls of long-term urbanization patterns and efforts aimed at creating more sustainable and healthier cities require careful consideration of population–transport feedbacks.

Photo credit: [NASA](https://commons.wikimedia.org/wiki/File:Bucharest_night_from_the_International_Space_Station.jpg)
İNFAZ VE KORUMA MEMURLARININ HİZMET SINIFI SORUNUNA YÖNELİK BİR ARAŞTIRMA
Authors: Sarsu Abdulkadir , Tahtalıoğlu Hava
Published: July 2024

Sınıflandırma kamu personelinin istihdamından emekliliğine kadar olan tüm süreci etkileyen, temel ilkelerinden biridir. Bu ilke personel sistemlerinin türüne göre farklı şekillerde düzenlense de diğer ilkeleri etkilediğinden dolayı önemli bir yere sahiptir. Türk kamu personel sistemi açısından da önemli olan sınıflandırma ilkesi oluşturulma şekli, yapısı ve ihtivası dolayısıyla zaman zaman sert eleştirilere konu olmaktadır. Hali hazırda 12 hizmet sınıfı bulunan sistemde özellikle Genel İdare Hizmetleri Sınıfı, diğer hizmet sınıfları içerisine dâhil olamayan, birbirinden farklı özelliklere sahip meslek gruplarını içerisinde barındırmasından dolayı en çok eleştirilen sınıftır. Bu çalışmada, Türkiye’de bulunan ceza infaz kurumlarının iç güvenliği ile denetim ve gözetiminden sorumlu infaz ve koruma memurlarının hizmet sınıfı sorununa ilişkin algılarının ölçülmesi amaçlanmaktadır. Alan araştırması kapsamında Mersin/Tarsus, Adana ve Niğde İlinde bulunan Ceza İnfaz Kurumları örneklem olarak seçilmiştir. Bu kurumlarda çalışan 480 infaz ve koruma memurundan veriler toplanmıştır. Katılımcıların demografik özelliklerine göre elde edilen verilerin farklılaşıp farklılaşmadığını tespit etmek amacıyla T-testi ve tek yönlü varyans analizi uygulanmış, anlamlı farklılık bulunan ifadeler irdelenmiş ve yorumlanmıştır. Sonuç olarak infaz ve koruma memurlarının istihdam edildikleri sınıf ile hizmet gereklerinin bağdaşmadığı yönünde algılarının yüksek olduğu ve yeni bir hizmet sınıfının oluşturulması gerektiği kanaatinde oldukları görülmüştür.
Using modified Delphi method to explore the key success factors of enterprise service volunteer groups: A case study of SME Honorary Instructors Association
Authors: Chieh-Shuo Chen Chieh-Shuo Chen , Chieh-Shuo Chen Sheue-Yu Hung , Sheue-Yu Hung Ling-Hsuan Cheng
Published: July 2024

With the advancement of society, voluntary service has become a prevalent phenomenon in the participation of citizens in many modern nations. In Taiwan, there exists a distinctive enterprise service volunteer groups known as the Small and Medium Enterprise Honorary Instructors Association (SMEHIA). This association is comprised of entrepreneurs, experts, and scholars who have been vetted and trained by the Small and Medium Enterprise Administration of the Ministry of Economic Affairs. These individuals possess extensive professional knowledge or technical expertise and are willing to voluntarily serve Small and Medium Enterprises (SMEs) without compensation. The primary function of SMEHIA is to provide services to domestic SMEs and to serve as a crucial communication bridge between the government and SMEs. The purpose of this study is to focus on this volunteer organization and employs modified Delphi method expert questionnaires to explore and identify the key success factors of this enterprise service volunteer groups encompass government policy, organizational culture, professional training, budgeting, volunteer self-identity dimensions, totaling 42 key factors. The implications of this study can serve as references for the future development of enterprise service volunteer organizations and for the formulation of policies by supervisory authorities.

 