bluuebunny/crossref_metadata_2025 huggingface dataset:
Is Green Profitable? A Look at Carbon Efficiency and Returns in Brazil’s Stock Market (B3)
Authors: Senna Asafe , Moxoto Ana Claudia de Araujo
Published: January 2025

This study explores the correlation between carbon emissions and financial performance in 73 companies in the Brazilian stock market(B3) and B3's Efficient Carbon Index (ICO2) in 2021. Linear regression models were used to analyze the impact of carbon emissions (EMC) on Profit per share (LPA), return on assets (ROA), and return on equity (ROE) while taking into account debt (END). We employed descriptive statistical methods to carry out this study and used ordinary least squares (OLS) and generalized least squares (GLS) estimation models. The econometric analysis software Gretl was used for linear regression analysis. The study found that, on average, companies with higher CO2 emissions had better financial performance in terms of EPS and ROE. However, the relationship between carbon emissions and financial performance is complicated, and the results should be interpreted cautiously, considering the study's limitations. This study aims to explore the correlation between carbon emissions and financial performance in 73 companies listed in B3's Efficient Carbon Index (ICO2) in 2021. Linear regression models were used to analyze the impact of carbon emissions (EMC) on Profit per share (LPA), return on assets (ROA), and return on equity (ROE) while taking into account debt (END). We employed descriptive statistical methods to carry out this study and used ordinary least squares (OLS) and generalized least squares (GLS) estimation models. The econometric analysis software Gretl was used for linear regression analysis. The study found that, on average, companies with higher CO2 emissions had better financial performance in terms of EPS and ROE. However, the relationship between carbon emissions and financial performance is complicated, and the results should be interpreted cautiously, considering the study's limitations.
Predicting Quality of Life in Patients with Heart Failure with Preserved Ejection Fraction by Analyzing the H2FPEF Score
Authors: Ciobanu-Teașă Alina , Guberna Suzana-Maria , Jercălău Cosmina Elena , Ceban Octavian , Andrei Cătălina Liliana , Sinescu Crina Julieta
Published: January 2025

Background/Objectives: This study aims to find a way to predict the quality-of-life factors in patients with heart failure with preserved ejection fraction based on H2FPEF score; Methods: We performed a prospective observational analysis on 158 hospitalized patients diagnosed with HFPEF who were followed for 12 months after discharge. During hospitalization, we calculated the H2FPEF score for each patient. The follow-up after discharge aimed to monitor the limitation of the usual physical activity, the recently installed fatigue, the presence of leg edema, the ability to exercise regularly and the sadness. We thus obtained data about the quality of life of these patients, the physical and mental limitations, the number of readmissions and the percentage of mortality. To estimate the relationship between the H2FPEF score and each variable we used logistic regression models, providing probabilities for each sign or symptom of the disease mentioned by the patient; Results: All observed variables show statistical significance. The strongest relationship with the H2FPEF score is observed in marked limitations of physical activity, followed by edema and regular exercise; Conclusions: Our research shows a way to predict the quality of life of HFPEF patients using the H2FPEF score. We have demonstrated that the H2FPEF score does not only play a role in the diagnosis of the disease but is also a tool for assessing the quality of life in these patients. By quickly calculating the H2FPEF score we can predict which patients are at high risk and require more medical resources.
Three-Layer Framework Integrating Optimal Placement of SCADA Measurements with Clustering-Based Electric Substations Selection for State Estimation of Medium-Voltage Distribution Networks
Authors: Dandea Vasilica , Galbau Stefania , Baciu Mihai-Alexandru , Grigoras Gheorghe
Published: January 2025

The continuous monitoring of modern electric distribution networks (EDNs) is essential for accurate situational awareness and state estimation. This paper proposed a robust and resilient three-layer methodology for state estimate of the EDNs based on an optimal placement algorithm of the remote terminal units integrated into the supervisory, control, and acquisition system (SCADA) at the level of the electric distribution substations (EDSs) to perform on-site measurements. The first layer allows the determination of the classes of the EDSs with similar features of the load profiles identified through a correlation matrix using the K-means clustering algorithm. The second layer identifies the “candidate” classes and decides the pilot EDSs with on-site SCADA measurements. The optimal placement corresponds to the minimization of the load estimation errors obtained using the multiple linear regression models between the EDSs from the classes not included in the set of the “candidate” classes and the pilot EDSs. The third layer allows the state estimation of the EDN based on the load values measured in the pilot EDEs and the other EDSs obtained through the regression models. The base testing and validating of the proposed framework was a real urban medium voltage electric distribution network. The results obtained highlighted that the accuracy had been ensured for on-site measurements in 12 of 39 EDSs (representing 30% approximately of EDSs integrated into the SCADA system), leading to a mean average percentage error of 2.6% for the load estimation and below 1% for the state variables at the level of the EDN.
Innovations and Mechanisms in Liposomal Drug Delivery: A Comprehensive Introduction
Authors: Sengar Ashutosh
Published: January 2025

Liposomal drug delivery systems are one of the most promising innovations to revolutionize this pharmaceutical industry. It incorporates drugs with hydrophilic as well as hydrophobic properties into a biocompatible lipid bilayer. In this review, general properties of liposomes will be discussed, including composition and mechanisms involved in the augmentation of drug solubility, stability, and targeted delivery. It referred to the development of liposomal formulations and important milestones, such as the FDA approval of Doxil, as the turning points in the clinical application of liposomes. It has been used in the therapeutic field of oncology where the systemic toxicity reduces simultaneously while making the therapy more effective. Also emphasized in this paper are the advantages of liposomal systems, sustained release profiles, and combination therapies that can help against the problem of drug resistance. A further review of the current clinical applications of liposomes is advanced in order to show successful products which have, indeed, impacted the treatment of a patient. There's a good scope for the integration of liposomal technology with novel therapeutic strategies and it's in this direction that the mandate of treating more effectively and personalizing treatment may be considered. The review focuses on the critical role of liposomal drug delivery systems in modern medicine, underlining their potential to revolutionize therapeutic approaches and patient outcomes.
Comparative Assessment of Cochrane’s ROB and ROB2 in Dentistry Trials: A Meta-Research Study
Authors: Viana Joao , Machado Vanessa , Proença Luis , Chambrone Leandro , Botelho João
Published: January 2025

This meta-research study aimed to compare the assessment of Cochrane's Risk of Bias (RoB) and RoB2 tools in dentistry trials. A sample 150 in vivo randomized clinical trials published between 2020 and 2022 was randomly selected from PubMed/Medline, Sco-pus, and EMBASE databases (50 per year). For each study, the impact factor, journal quartile, adherence to CONSORT guidelines, date information availability, and study model were recorded. The results showed that 33.3% of the studies were categorized as low risk of bias by both RoB and RoB2. However, 29.6% of the studies classified as low risk by RoB were downgraded to some concerns in RoB2, and 37% were downgraded to high risk. In the some concerns category, 25.9% were upgraded to low risk, 37% re-mained constant, and 37% were downgraded to high risk in RoB2. Among the high risk studies, 14.6% were upgraded to low risk, 26% to some concerns, and 59.4% remained constant in RoB2. The level of agreement between RoB and RoB2 was found to be low for dental studies. These findings highlight the differences between the two tools and the potential impact on the synthesis of evidence and decision-making processes in dental research.
Assessing the Efficacy of Biochar in Remediation of Polymetallic Highly Contaminated Soils with Different Levels of Humus Content
Authors: Gorlenko Mikhail , Kozlova Irina , Kulachkova Svetlana , Terekhova Vera
Published: January 2025

The effects of biochar on heavy polymetallic contamination in Albic Glossic Retisols with varying humus content is evaluated using ecotoxicological and microbiological parameters. Soils were contaminated with elevated levels of Cu, Zn, and Pb at concentrations five and ten times higher than Russia's Approximate Allowable Concentrations (AAC). Biochar application significantly reduced ecotoxicity in low humus soil, or S2 (1.30% Corg), at 5 AAC, leading to a 25% increase in plant root length and a 54% rise in root biomass. However, at 10 AAC, heavy metals completely inhibited these test responses. In highly humified soil, or S1 (3.86% Corg), biochar did not significantly improve ecotoxicological or microbiological parameters regardless of contamination levels. A significant positive impact on microbial functional activity was observed only in the low humus soil (S2), with a 38% increase in microbial biomass carbon (Cmic), a 15% rise in basal respiration, and a 25% decrease in qCO2 under elevated heavy metal concentrations. Microbiome's functional diversity indicator, such as substrate utilization spectra, showed a 36% increase in S1 and a 54% increase in S2 due to biochar. The results suggest that the sensitivity of these indicators to biochar amendments depends on both soil contamination levels and humus content.
Study the Intensification of Atmospheric Gravity Waves (AGW) During Tropical Cyclones
Authors: Nanda Kousik , Sasmal Sudipta , Hazra Raka , Datta Abhirup , Panchadhyayee Pradipta , Potirakis Stelios M.
Published: January 2025

This study explores how the variation of atmospheric gravity waves (AGWs) get modified and intensified during tropical cyclones using high-resolution ERA5 reanalysis data. AGWs play a vital role in understanding tropical cyclone dynamics due to their connection with energy and momentum transfer in the atmosphere. Different issues related to six tropical cyclones in the Bay of Bengal from 2019 to 2022, spanning different intensities and seasonal conditions, have been analyzed. Using temperature and pressure data across 37 vertical levels, several variables like perturbation temperature and potential energy Ep profiles associated with AGWs are computed. Spatial temperature distributions and Ep exhibit spiral formations resembling cyclone structures with significant altitude-dependent variations. Temperature signatures are observed at altitudes between 1.5 km and 5.5 km, varying by season and intensity, while Ep signatures were prominent between 14.55 km and 19.31 km, peaking at 15.79 km for most cyclones except Cyclone Fani, which peaked at 17.66 km. Ep values ranged from 10 to 25 J/kg, reflecting strong AGW-cyclone interactions. These findings highlight the influence of cyclone intensity, seasonality, and atmospheric dynamics on AGW behaviour, enhancing the understanding of energy transfer processes in the upper troposphere and lower stratosphere.
Inflammatory Pathways in Coronary Artery Disease: Which Ones to Target for Secondary Prevention?
Authors: Cheng Wan Hei , Wang Ying
Published: January 2025

Coronary artery disease (CAD), the build-up of atherosclerotic plaques on the wall of blood vessels, causes adverse cardiovascular events, such as heart attack. In most cases, plaques are already established when patients are diagnosed with atherosclerotic disease. Therefore, therapeutic development aims to prevent the progression of existing plaques (secondary prevention). Recent studies have shown that inflammation is an independent risk factor that drives disease progression and targeting inflammation could be an effective therapeutic strategy to prevent adverse cardiovascular events in patients diagnosed with CAD. In the past 15 years, numerous pre-clinical studies and clinical trials have tested drug candidates that target specific inflammatory pathways or have broad anti-inflammatory effects, but only colchicine was approved for clinical use in patients with CAD. This is primarily due to a limited understanding of how inflammatory pathways drive disease progression from an established plaque to adverse cardiovascular events. In this review, we summarized inflammatory pathways found in pre-clinical models of atherosclerosis and treatment outcomes of clinical trials that target inflammation. We discussed the challenges of using commonly used models to identify potential therapeutic targets for secondary prevention. We aim to provide a comprehensive overview of how different inflammatory pathways may contribute to the progression of established plaques and what should be taken into consideration when selecting them as targets for secondary prevention.
The Influence of the Relationship Between Landmark symbol Types, Annotations, and Colors on Search Performance in Mobile Maps Based on Eye-Tracking
Authors: Fang Hao , Guo Hongyun , Song Zhangtong , Yang Nai , Wang Rui , Guo Fen
Published: January 2025

Mobile map landmark symbols are pivotal in conveying spatial semantics and enhancing users' perception of digital maps. This study employs a three-factor hybrid experimental design to investigate the effects of different landmark symbol types and their color associations with annotations on search performance using eye-tracking methods. Utilizing the Tobii X2-60 eye tracker, 40 participants engaged in a visual search task across three symbol types (icons, indexes, and symbols) and two color conditions (consistent and inconsistent). The study also examines the impact of gender on search performance. Results indicate that INDEX symbols, emphasizing landmarks' functions and key features, most effectively improve search accuracy and efficiency while demanding the least cognitive effort. In contrast, SYMBOL type characters, with clear semantics and minimal information, require less visual attention, facilitating faster preliminary processing. Additionally, cognitive style differences between genders affect these symbols' effectiveness in visual search. Careful selection of symbol types and color combinations can significantly enhance user interaction with mobile maps.
Host’s Factors and the Relative Abundance of Candida Species of Oral Squamous Cell Carcinoma Tissues in a Group of Sri Lankan Male Patients
Authors: Perera Manosha , Perera Irosha
Published: January 2025

The aim of this study was to discover the host factors and the relative abundance of Candida species associated with oral squamous-cell carcinoma (OSCC). DNA was extracted from 52 tissue biopsies (cases: 25 OSCC; controls and sequenced for the fungal internal transcribed spacer 2 region using Illumina™ 2 x300bp chemistry. Merged reads were classified to species level using a BLASTN-algorithm with UNITE’s named species sequences as reference. Candida albicans was flourished in OSCC tissues, followed by Candida tropicalis, Candida parapsilosis, Candida doubliniensis, Candida etchellsii, Candida metapsilosis, Candida santamariae and Candida albicans_nov_92.15%. The older age, low socio-economic status, poor oral hygiene status, periodontal disease status, oral risk habits, nutritional deficiencies, and OSCC status appeared as host factors that accounted for elevated C. albicans occurrence (61.2% of average relative abundance) in all OSCC tissues (100%) of a group of male patients. Powered matched case-control studies, controlling confounders to apply multivariate logistic regression are much recommended to find out the reliability of results of the present study.
Pichia kudriavzevii and Saccharomyces cerevisiae Strategies for Ciders Elaboration from Acidic Apples
Authors: Mazzucco Maria Belen , Jovanovich Milena , Rodríguez María Eugenia , Oteiza Juan Martín , Lopes Christian Ariel
Published: January 2025

Background: The cider industry is becoming an increasingly important segment of the apple fruit sector in Argentina. This study evaluated different inoculation strategies using two Patagonian strains to produce ciders with reduced malic acid and enhanced quality from acidic apple musts.

Methods: Fermentations were performed using Pichia kudriavzevii NPCC1651 (isolated from cider) and Saccharomyces cerevisiae ÑIF8 (isolated from wine) in pure, simultaneous, and sequential inoculations. Viable cell counts, glucose and fructose consumption kinetics, and malic acid depletion were measured during fermentation, while physicochemical and aromatic profiles of the ciders were also analyzed in the final products.

Results: P. kudriavzevii was capable to coexist with S. cerevisiae until the final stages of fermentation, independently from the inoculation strategy employed. The simultaneous inoculation at a 1:1 ratio and the sequential inoculation initiated with S. cerevisiae showed the best performance. Both strategies produced ciders with high fermentative efficiency, elevated levels of lactic and succinic acids, isoamyl alcohol, 2-phenylethanol, isoamyl acetate and 2-phenylethyl acetate, while reducing acetic acid and ethyl acetate levels. These fermentations also achieved higher malic acid consumption compared to pure cultures.

Conclusion: The simultaneous inoculation at a 1:1 ratio is proposed for further pilot-scale testing in natural acidic musts due to its operational practicality and its potential to produce ciders with reduced malic acid and improved sensory quality.
The Governance and Economy Impact of Forest Certification: A Comparative Analysis Between Malaysia and Sweden
Authors: Mohd Nor Shah Badri , Mohamed Ahmad Fariz , Khamis Shamsul
Published: January 2025

The forest certification is a voluntary program to ensure that the timber harvested from forests is conducted in a sustainable manner by following specific standards. Program for the Endorsement of Forest Certification (PEFC) introduced in 1999 using the bottom-up approach and gives a country flexibility to set-up their own PEFC standard based on current practice on Sustainable Forest Management (SFM), regulation, and governance. This practice has led to the development of various PEFC standards for each country; thus, the impact of PEFC certification found differs from each country. In accordance with that, this study aims to evaluate the PEFC standard application in developed and developing countries, namely Sweden and Malaysia. The study also analyzed the impact of forest certification on governance and economic aspects within Asia Pacific and Europe. The outcome of this study indicates that the PEFC standard developed by these countries shows similarities, for example, both countries focusing on social requirements and environmental requirements. While the difference is shown in criteria, term used, and focus area. The impact analysis shows that countries are facing a similar issue, especially market access and premium prices. This study show that the standard developed by each country differ depending on current practices, forest diversification and regulation.
Novel Vaccines Targeting the Highly Conserved SARS-CoV-2 ORF3a Ectodomain Elicit Immunogenicity in Mouse Models
Authors: Meza Jacob , Glass Elizabeth , Sandhu Avinaash K , Li Yangchen , Karanika Styliani , Fessler Kaitlyn , Hui Yinan , Schill Courtney , Wang Tianyin , Zhang Jiaqi , Bates Rowan E , Taylor Alannah D , Kapoor Aakanksha R , Ayeh Samuel K , Karakousis Petros C , Markham Richard B , Gordy James T
Published: January 2025

Background: The majority of antigen-based SARS-CoV-2 (SCV2) vaccines utilized in the clinic have had the Spike protein or domains thereof as the immunogen. While the Spike protein is highly immunogenic, it is also subject to genetic drift over time that has led to a series of variants of concern that continue to evolve, requiring yearly updates to the vaccine formulations. In this study, we investigate the potential of the N-terminal ectodomain of the ORF3a protein encoded by the orf3a gene of SCV2 to be an evolution-resistant vaccine antigen. This domain is highly conserved over time, and, unlike many other SCV2 conserved proteins, it is present on the exterior of the virion, making it accessible to antibodies. ORF3a is also important for eliciting robust anti-SARS-CoV-2 T-cell responses. Methods: We designed a DNA vaccine fusing the N-terminal ectodomain of orf3a to macrophage-inflammatory protein 3α (MIP3α), which is a chemokine utilized in our laboratory that enhances vaccine immunogenicity by targeting antigen to its receptor CCR6 present on im-mature dendritic cells. The DNA vaccine was tested in mouse immunogenicity studies, vaccinating by intramuscular (IM) electroporation and by intranasal (IN) with CpG adjuvant administrations. We also tested a peptide vaccine fusing amino acids 15-28 of the ectodomain to immunogenic carrier protein KLH, adjuvanted with Addavax. Results: The DNA IM route was able to induce 3a-specific splenic T-cell responses, showing proof of principle that the region can be immunogenic. The DNA IN route further showed that we could induce ORF3a-specific T-cell responses in the lung, critical for potential disease mitigation. The peptide vaccine elicited a robust anti-ORF3a antibody response systemically as well as in the mucosa of the lungs and sinus cavity. Conclusions: These studies collectively show that this evolutionarily stable region can be targeted by vaccination strategies, and future work will test if these vaccines alone or in combination can result in reduced disease burden in animal challenge models.
Medical Mistrust: A Concept Analysis
Authors: Shukla Meghna , Solberg Marvin Allan , Gibson-Scipio Wanda
Published: January 2025

Background The term “medical mistrust” has increased in literary usage within the last ten years, but the term has not yet been given a full conceptualization. This article analyzes usage of the term “medical mistrust” in extant literature in order to articulate its antecedents, attributes, and consequences. The aim of this article is to provide a preliminary conceptual definition and conceptual figure for medical mistrust. Methods Walker & Avant’s (2019) conceptual analysis method was used. PUBMED, CINAHL, SCOPUS, PSYCinfo, and Google search engines were used. Results Medical mistrust is a social determinant of health fueled by a fear of harm and exploitation, and is experienced at both the interpersonal and institutional level, reinforced by structural racism and systemic inequalities. Medical mistrust is predicated by historical trauma, socioeconomic disparities, medical gaslighting, medical traumatic experiences, maladaptive health beliefs and behaviors, individual minority identity, and is transmitted intergenerationally and culturally. Consequences of medical mistrust include underutilization of health services, delays in diagnosis and care, poor treatment adherence, poor health outcomes, negative psychological effects, and an increase in the uptake of medical misinformation and maladaptive health behaviors. Conclusion The findings of this concept analysis have important implications for healthcare providers, healthcare systems, researchers, as well as healthcare policy makers.
Fatigue Effects on Electromyography Signals on Resting Muscle
Authors: Vital-Ochoa Omar , Acosta-Elias Jesus , Mendez-Moreno Santiago , Espinosa Laura , Espinosa-Tanguma Ricardo
Published: January 2025

It is widely accepted that a resting muscle does not present detectable electromyographic signals at the skin surface (sEMG). For this reason, studies on resting muscle tone often focus on measuring mechanical properties, such as stiffness, tension, and elasticity, either through palpation or specific devices. In this study, the superficial flexor muscle of the fingers was analyzed. First, the Power Spectral Density (PSD) was obtained in a resting state (PSD_pre). Subsequently, the muscle was subjected to a fatigue protocol, and immediately, after returning to the resting state, the PSD was measured once again (PSD_pos). The results suggest that the muscle at rest presents detectable electromyographic signals. Furthermore, the Wilcoxon signed rank test indicates a statistically significant decrease in PSD_pre compared to PSD_pos, with a 95% confidence level (p-value = 0.00443). In other words, the resting muscle, after experiencing fatigue, shows a greater accumulation of power in its sEMG signal compared to the pre-fatigue state.
Flavonoids-Rich Extracts from Chuju (Asteraceae Chrysanthemum L.) Alleviate Disturbance of Glycolipid Metabolism on Type 2 Diabetic Mice via Modulating the Gut Microbiota
Authors: Yin Yu , Nie Wen , Tang Zheng-Quan , Zhu Shuang-Jie
Published: January 2025

The prevention of type 2 diabetes mellitus (T2DM) and its associated complications is an urgent public health issue that affects hundreds of millions of people globally. Chuju has been proved to possess antihyperglycemic activity. However, the bioactive ingredients in chuju that contribute to antihyperglycemic activity as well as the relation between its antihyperglycemic activity and gut microbiota remain unclear. To understand the potential effect it has on T2DM, the glycolipid metabolism and gut microbiota regulation of flavonoids-rich extracts from chuju (CJE) were investigated. The results showed that CJE remarkably mitigated hyperglycemia and glycolipid metabolism by regulating the gut microbiota in T2DM mice. Furthermore, the macro-genome sequencing results showed that CJE intervention regulated the composition of gut microbiota in T2DM mice, characterized by downregulating the abundance of Faecalibaculum, Coriobacteriaceae, Romboutsia and up-regulating the abundance of Alistipes. In addition, CJE could promote glycogen synthesis, gluconeogenesis, glucose transport and inhibite glycolysis by regulating the expression of insulin-mediated IRS1-PI3K-Akt-FoxO1/GSK 3β pathway and non-insulin-mediated AMPK-GLUT4 pathway. Taken together, the results provided new evidence that CJE alleviate disturbance of glycolipid metabolism via regulating gut microbiota and mediating IRS1-PI3K-Akt-FoxO1/GSK 3β, AMPK-GLUT4 pathway.
Rank-Based Psychological Characteristics of Brazilian Jiu-Jitsu Athletes: Mental Strength, Resilience, Grit, Self-Efficacy, Self-Control, Aggression, Life Satisfaction, and Mental Health
Authors: Lorenco-Lima Leandro , Gaines Stacey A. , Waterbury Elisabeth M.
Published: January 2025

Brazilian jiu-jitsu engagement has been found to positively impact psychological variables in children, adolescents, and adult athletes. Psychological variabilities have been previously shown among belt ranks in Brazilian jiu-jitsu athletes. Background/Objectives: This study aimed to explore the differences in mental strength, resilience, grit, self-efficacy, self-control, aggression, life satisfaction, and mental health disorders among the Brazilian jiu-jitsu belt ranks. Methods: A sample of 420 Brazilian jiu-jitsu athletes (78.8% male), including 121 white belts, 118 blue belts, 78 purple belts, 46 brown belts, and 57 black belts, between 18 and 60 years of age, completed the Mental Strength Scale, Brief Resilience Scale, Grit Scale, General Self-Efficacy Scale, Brief Self-Control Scale, Brief Aggression Questionnaire, Satisfaction with Life Scale, and Mental Health Disorders Screening Instrument for Athletes. Results: Results showed that Brazilian jiu-jitsu black belts presented significantly higher mental strength, resilience, self-efficacy, self-control, life satisfaction, and lower mental health disorders than white belts. No significant differences were found between white and black belts in aggression (total, physical aggression, anger, verbal aggression, and hostility). Brazilian jiu-jitsu training experience positively correlated (small effect) with mental strength, resilience, grit, self-efficacy, self-control, physical and verbal aggression, and life satisfaction. Conclusions: In conclusion, the results suggest that Brazilian jiu-jitsu black belts are generally more likely to present higher mental strength, resilience, grit, self-efficacy, self-control, life satisfaction, and better mental health than white belts, with no differences in aggression. More experienced Brazilian jiu-jitsu athletes were more likely to present higher mental strength, resilience, grit, self-efficacy, self-control, physical and verbal aggression, and life satisfaction than less experience athletes. Future studies are encouraged to explore whether these characteristics are prerequisites for continued Brazilian jiu-jitsu training or whether a causal relationship exists.
Therapeutic Potential of Mineralocorticoid Receptors in Skeletal Muscle Aging
Authors: Nucci Ricardo Aparecido Baptista , Nóbrega Otávio Toledo , Jacob-Filho Wilson
Published: January 2025

Skeletal muscle aging, or sarcopenia, involves progressive muscle mass and function loss, which limits mobility and independence in the aged populations. This decline is driven by chronic inflammation, oxidative stress, and insulin resistance, all of which impair muscle regeneration and accelerate protein breakdown. Mineralocorticoid receptors (MRs), known for roles in electrolyte balance, have emerged as key regulators of these processes in skeletal muscle. MR activation promotes inflammatory signaling, increases oxidative stress, and worsens insulin resistance, accelerating sarcopenia progression. This review examines the impact of MRs on muscle health and highlights the therapeutic potential of targeting these receptors to counteract age-related muscle loss. MR antagonists, such as spironolactone, show promise in reducing inflammation and oxidative damage, potentially slowing sarcopenia. Physical exercise, an established intervention for muscle health, may enhance MR antagonism effects by improving insulin sensitivity and reducing inflammation. However, more research is needed to determine the efficacy and safety of combined MR antagonists and exercise protocols for preventing sarcopenia in older adults.
‘A Phenix whose ashes yeldes another bryde’: Anne Boleyn’s Memory in the Reign of Elizabeth I
Authors: Beesley Jack
Published: January 2025

Queen Elizabeth I (1533 – 1603) occupied the English throne for 45 years in what has become known as England’s ‘Golden Age’. Her reign is one of the most studied and deliberated of any English monarch, and yet, there is one aspect of Elizabeth’s life which remains an enigma, namely her feelings towards her mother, Anne Boleyn (c.1501 – 1536). Anne was infamously executed on the orders of Elizabeth’s father, Henry VIII (1491 – 1547), in 1536 on false charges of adultery, incest and treason when Elizabeth was two years and eight months old. Elizabeth rarely spoke of her mother, therefore, there is much ambiguity surrounding her feelings towards Anne. This has allowed for a range of theories to develop. Some historians believe that Anne’s death was simply of no consequence to Elizabeth. David Starkey remarked that she “airbrushed her mother from her memory.” In contrast, other scholars have used psychoanalytic theory to suggest that Elizabeth suffered from the oedipal complex as a result of Anne’s fall. These hypotheses are a misleading representation of not only Elizabeth’s sentiments for her mother, but also the intricate impact that Anne’s memory had on her reign. Through the analysis of literary sources, portraiture and material objects, this article will work to challenge these theories. Instead, it will suggest that Elizabeth subtly contributed to the rehabilitation of Anne’s memory, adhering to a figurative and symbolic understanding of their relationship as expressed in the works of Protestant authors. This will reveal Anne’s multifaceted legacy to Elizabethan England, in which her memory was used to both legitimise and destabilise Elizabeth’s monarchy.
Gene Expression Alteration by Non-thermal Plasma-Activated Media Treatment in Radioresistant Head and Neck Squamous Cell Carcinoma
Authors: Zheng Sicong , Piao Yudan , Jung Seung-Nam , Oh Chan , Lim Mi Ae , Nguyen QuocKhanh , Shen Shan , Park Se-Hee , Cui Shengzhe , Piao Shuyu , Kim Young Il , Kim Ji Won , Won Ho-Ryun , Chang Jae Won , Shan Yujuan , Liu Lihua , Koo Bon Seok
Published: January 2025

Objectives. Head and neck squamous cell carcinoma (HNSCC) exhibits high recurrence rates, particularly in cases of radioresistant HNSCC (RR-HNSCC). Non-thermal plasma (NTP) therapy effectively suppresses the progression of HNSCC. However, the therapeutic mechanisms of NTP therapy in treating RR-HNSCC are not well understood. In this study, we explored the regulatory role of NTP in the RR-HNSCC signaling pathway and identified its signature genes.Methods. After constructing two RR-HNSCC cell lines, we prepared cell lysates from cells treated or not treated with NTP-activated media (NTPAM) and performed RNA sequencing to determine their mRNA expression profiles. Based on the RNA sequencing results, we identified differentially expressed genes (DEGs), followed by a bioinformatics analysis to identify candidate molecules potentially associated with NTPAM therapy for RR-HNSCC.Results. NTPAM reduced RR-HNSCC cell viability in vitro. RNA sequencing results indicated that NTPAM treatment activated the reactive oxygen species (ROS) pathway and induced ferroptosis in RR-HNSCC cell lines. Among the 1,924 genes correlated with radiation treatment, eight showed statistical significance in both the cell lines and The Cancer Genome Atlas (TCGA) cohort. Only five genes—ABCC3, DUSP16, PDGFB, RAF1, and THBS1—showed consistent results between the NTPAM data sequencing and TCGA data. LASSO regression analysis revealed that five genes were associated with cancer prognosis, with a hazard ratio of 2.26. In RR-HNSCC cells, NTPAM affected DUSP16, PDGFB, and THBS1 as activated markers within 6 hours, and this effect persisted for 12 hours. Furthermore, enrichment analysis indicated that these three DEGs were associated with the extracellular matrix, transforming growth factor-beta, phosphoinositide 3-kinase/protein kinase B, and mesenchymal-epithelial transition factor pathways.Conclusion. NTPAM therapy exerts cytotoxic effects in RR-HNSCC cell lines by inducing specific ROS-mediated ferroptosis. DUSP16, PDGFB, and THBS1 were identified as crucial targets for reversing the radiation resistance induced by NTPAM therapy, providing insights into the mechanisms and clinical applications of NTPAM treatment in RR-HNSCC.
Peran Administrasi Bisnis Dalam Implementasi Komunikasi Organisasi Jaringan Franchise Warung Tegal Jabodetabek
Authors: Tursanurohmad Noviana , Made Wilantara Made Wilantara , Misnan Misnan , Pranawukir Iswahyu
Published: January 2025

This study aims to analyze the role of business administration in implementing organizational communication within the Warung Tegal (Warteg) franchise network in the Jabodetabek area. The research employs a qualitative descriptive method, focusing on analyzing the realities faced by the Warteg franchise network regarding business administration and organizational communication. The findings reveal that although the Jabodetabek Warteg franchise has adopted the franchise model, its impact on elevating the status of traditional Warteg establishments remains insignificant. Several positive factors were identified, including (1) profitability due to the provision of staple foods, (2) an automated operational system that does not require startup or specific marketing strategies, (3) a well-established brand, (4) a clear operational system, (5) a modern 3S (Neat, Clean, Compact) building concept, and (6) an effective application of the GFC (Good, Fast, Cheap)principle. However, there are still some limitations, such as (1) a lack of strong positioning, both functionally (addressing hunger) and emotionally (appealing to a specific consumer segment), (2) the product’s brand character has not achieved top-of-mind awareness among consumers, (3) a lack of differentiation in terms of taste or customer experience, (4) suboptimal location strategy due to limited parking space, and (5) challenges in meeting online order demands. Additionally, the study uncovers opportunities for further development, such as flexible partnership packages that offer a quick return on investment, well-established managerial SOPs, franchisers assisting with location selection, and a cooperative leadership role. A key finding is that, among seven Warteg franchises, the “New Bahari” (WNB) network has successfully implemented digital technology through an ERP (Enterprise Resource Planning) system with real-time control applications, YouTap POS and YouTap BOS.
Strategies of Virtual Influencers Crafting Viral Content in Indonesia
Authors: Zenobia Zhafira , Christin Maylanny
Published: January 2025

Virtual influencers are becoming increasingly popular on social media, with many major brands targeting young consumers preferring virtual influencers as they are easier to manage compared to human influencers. This study aims to analyze the digital storytelling strategies and representations of virtual influencers from various countries, specifically Indonesia, the United States, and Brazil, on social media platforms like TikTok. Using a qualitative method with narrative analysis, this study found that virtual influencers reflect significant cultural and market differences based on their promotional focus and content style. For instance, Indonesian virtual influencer Arbie Seo promotes products from the brand Nabati, and Lentari Pagi focuses on promoting sports events like e-football. Meanwhile, American virtual influencer Lil Miquela collaborates with major brands like Dior, and Lu do Magalu from Brazil promotes household products. Digital storytelling is compelling as it unconsciously draws audiences into following storylines by integrating multimedia elements presented by virtual influencer content. This strategy not only enhances audience engagement but also increases the potential for content to go viral. This study provides insights into how virtual influencers build audience connections through storytelling and appealing representations.
Estrés académico y síntomas gastrointestinales autoreportados en los estudiantes de Medicina Humana de la Universidad Científica del Sur durante la temporada de exámenes
Authors:   , Caceres Henostroza Ximena Alexandra , Zamalloa Ramos Fiorella Jesus
Published: January 2025

Objetivo. Determinar la relación entre el nivel de estrés académico y la severidad de síntomas gastrointestinales autoreportados en los estudiantes de Medicina Humana de la Universidad Científica del Sur durante la temporada de exámenes. Materiales y métodos. Estudio observacional de tipo analítico transversal, se incluyeron a 119 estudiantes mediante un muestreo no probabilístico por cuotas. Para evaluar las variables de estudio se aplicaron; la escala DASS-21 (Escala de Depresión, Ansiedad y Estrés) y escala GSRS (Escala de calificación de síntomas gastrointestinales). Para el análisis de datos se empleó la correlación de Spearman. Resultados. Se evidenció que, el dolor o malestar en la parte alta del abdomen o en la boca del estómago (P=0.001; rho=370), ardor de estómago (P=0.002; rho=0.279), reflujo ácido (P=0.001; rho=0.299), sensación de hambre (P=0.001; rho=0.415), hinchazón de estómago (P=0.001; rho=0.326), estreñimiento (P=0.025; rho=0.206), diarrea (P=0.047; rho=0.183), necesidad urgente de hacer deposiciones (P=0.022; rho=0.209) y sensación de no haber terminado de defecar (P=0.023; rho=0.209) se asociaron de manera significativa al nivel de estrés durante la evaluación de exámenes. Conclusiones. Se encontró una relación significativa entre el nivel de estrés y la severidad de síntomas gastrointestinales (dolor o malestar en la parte alta del abdomen o en la boca del estómago, ardor de estómago, reflujo ácido, sensación de hambre, hinchazón de estómago, estreñimiento, diarrea, necesidad urgente de hacer deposiciones, sensación de no haber terminado de defecar).
Impacto de la pandemia por covid-19 en los indicadores nutricionales en pacientes desde los 6 meses hasta los 59 meses de edad de zonas rurales
Authors:   , Campos Rojas Valery Alexandra , Acuña Davila Marycielo del Milagro
Published: January 2025

Objetivos: Demostrar el impacto de la pandemia por el COVID-19 en los indicadores nutricionales en pacientes entre los 6 meses hasta los 59 meses de edad de poblaciones rurales del Perú en el periodo 2019-2020. Materiales y métodos: Se realizó un análisis secundario de la base de datos del “Sistema de información del Estado Nutricional de niños y gestantes Perú - INS/CENAN 2019 – 2020” de los departamentos de Cajamarca, Huancavelica y Loreto. Se definieron dos grupos de intervención. El primer grupo de estudio que estuvo conformado por niños atendidos antes del periodo prepandémico y el segundo grupo conformado por niños atendidos en periodo pandémico. Todos los cálculos estadísticos se realizaron en el programa Stata 13. Resultados: Nuestro estudio muestra que de 145,192 niños entre los 6 a 59 meses con algún tipo de malnutrición, la prevalencia de desnutrición aguda aumentó un 0,45% y la prevalencia de desnutrición crónica disminuyó un 2,1%. Además, se evidenció una disminución en la incidencia de tres tipos de anemia, liderado por anemia leve la más común con un 1,01%, continuada por la anemia moderada con un 4,16% y la anemia grave con un 0,13%. Conclusiones: El COVID-19 tuvo mayor impacto en las zonas rurales con población en situación de pobreza modificando los indicadores nutricionales y, posteriormente, aumentando la prevalencia de enfermedades crónicas como anemia y desnutrición entre los niños.
Diseño de un humedal artificial en la ribera del río Tulumayo para remediación de aguas afectadas por cromo y cadmio provenientes de actividades mineras, Chanchamayo, Junín
Authors:   , Carpio Segovia Alejandra Isabel , Toro Ruiz Vanessa Scarleth
Published: January 2025

La minería es una de las principales causantes de la contaminación y alteración de ecosistemas fluviales en Perú, afectando la salud de organismos acuáticos y terrestres por la concentracón acumulada de agentes contaminantes como cadmio (Cd) y cromo (Cr). La presente investigación busca identificar zonas impactadas por la minería metálica en la selva peruana durante los años 2018, 2019 y 2020, enfocándose en los departamentos de Loreto, Amazonas, San Martín, Ucayali, Madre de Dios, Junín y Huánuco, a través de un mapa base y un análisis geoespacial de las áreas con presencia de actividad minera metálica informal, pasivos ambientales mineros (PAM) y denuncias ambientales. Asimismo, busca calcular las dimensiones de un humedal artificial de flujo subsuperficial usando la especie nativa Tessaria integrifolia Ruiz & Pav. con el fin de remover cadmio (Cd) y cromo (Cr) de aguas provenientes del río Tulumayo ubicado en Chanchamayo, Junín. Para ello, se consideró la población de la ciudad de San Ramón, el caudal poblacional, el caudal agrícola y los modelos de fósforo y nitrógeno. Los resultados señalan que las zonas críticas afectadas por la minería metálica en la selva peruana se ubican en los departamentos de Madre de Dios, Huánuco, Junín y Amazonas. Por otro lado, las dimensiones del humedal artificial fueron: 19,42 m de ancho, 38,96 m de largo y un área transversal de 15,98 m2, con una profundidad de 0,8 m. Esta estructura ocupa un área aproximada de 758,92 m2, con una capacidad de diseño de 779,19 m3. día-1 para obtener una efectividad del 50% de remoción de cromo y cadmio con una población de 200 personas y un caudal poblacional de 30 m3.d-1. En la presente investigación, la implementación de un humedal artificial de flujo subsuperficial horizontal representa una opción integrada y sostenible para la remoción de cadmio y cromo...
Premedicación con corticoides en el éxito del bloqueo del nervio alveolar inferior en pacientes con pulpitis irreversible sintomática: una revisión sistemática
Authors:   , Siles Garcia Adriana Abigail
Published: January 2025

El objetivo de esta revisión sistemática fue sintetizar la evidencia para determinar la efectividad de la premedicación con corticoides para incrementar la eficacia de los anestésicos locales en el bloqueo del nervio dentario inferior (BNDI) en pacientes con pulpitis irreversible sintomática. Cuatro bases de datos (PubMed, Central, Scopus, Google Scholar) fueron utilizadas para la realización de la búsqueda desde enero 2000 hasta febrero del 2023. La búsqueda manualmente se complementó en las principales revistas especializadas en odontología y endodoncia: International Endodontic Journal, Journal of Endodontics, Journal of Dental Research, Journal of the American Dental Association y Australian Endodontic Journal. La búsqueda inicial recopiló un total de 566 artículos, de los cuales 77 artículos se eliminaron como duplicados. De los 462 artículos restantes, 7 artículos fueron incluidos para la evaluación de la síntesis cualitativa de la evidencia. Para cada uno de los artículos seleccionados se presentaron 57,1% de artículos con bajo riesgo de sesgo (n=4/7), 14,2% con riesgo poco claro (n=1/7) y 28,5% con alto riesgo de sesgo y (n=2/7). Se concluyó que el éxito del BNDI es mayor con el uso de corticoides como premedicación vía oral o intraligamentaria para pacientes con pulpitis irreversible sintomática en molares mandibulares siendo la dexametasona de 4 mg administrada vía oral 1 hora antes del procedimiento eficaz en el BNDI al igual que el uso de prednisolona de 20 mg a 40 mg vía oral. Sin embargo, se recomienda indagar los efectos de otros corticoides como metilprednisolona como premedicación ya que no se hallaron estudios para comparar.
Information technologies for solid mineral extraction in the Arctic
Authors:   Empress Catherine II Saint Petersburg Mining University, Makhovikov Alexei , Filyasova Yulia ,   Herzen State Pedagogical University of Russia
Published: January 2025

Introduction. The research of the industrial information technologies (IT) is relevant for an active implementation of innovations into solid mineral extraction. The low human adaptation level to the hostile Arctic environmental conditions explains the high relevance of the IT in terms of breadth of their functional application. The aim of this research was to study the international and domestic experience of the IT deployment and the attempt to identify their role. Research methods and materials. Results of geophysical, physical, and environmental research as well as production mining and operations made by Russian and foreign scientists served as the material for analysis. The research was fulfilled with the use of the following methods: the analysis of scientific and technical findings, the study of core business activities, the classification and comparison of digital data. Research results. The main trend is the intention of a complete automation of the mining process, which has led to the emergence of multiple achievements in the technological process automation. The second trend is the elimination of workers’ participation on extraction sites. The third trend is the environmental maintenance in the mining area. Conclusions. It was found that the development of algorithmized systems for complete automation of the solid mineral extraction process is a highly relevant task. Nowadays, the IT are predominantly used at the stage of solids mineral exploration, the prediction of mineral deposit size, and the economic evaluation of mining operations. In the process of solid mineral extraction IT are used to a lower extent, due to high risks of cyber security and robotized integration of all technological objects and processes. At the completion stage of mineral excavation, IT have a significant value for landscape modeling and environmental parameter measuring.