bluuebunny/crossref_metadata_2025 huggingface dataset:
Otomasi ULFJ Margonda Raya Sebagaimana Diatur Melalui Permen PUPR Tentang ULFJ dengan Menggunakan Algoritma Aplikasi Ms. Excel
Authors: Sumabrata Jachrizal , Parlambang Satria Adipradana , Adwitiya R Ivan
Published: October 2023

One of the leading causes of death on earth is traffic accidents. Traffic accidents occur for many reasons. One reason is the condition of the road itself. Depok is a sub-urban area of Greater Jakarta that has the Margonda Highway as one of its main roads. That highway has become strategic as a "backbone" in supporting the wheel of economics and societies in Depok’s civilization. Road Function Compliance Evaluation (RFCE) is a process of evaluating the compliance of a road component to the standards that have been made by authorities for safety reasons to avoid traffic accidents. Therefore, a road’s compliance should be evaluated periodically to minimize the possibility of traffic accidents. Up to this moment, RFCE is still executed by filling out a form manually. In this technological era, it seems that RFCE should be implemented into an automation application using an algorithm.

ABSTRAK

Penyebab utama kematian dunia salah satunya adalah disebabkan oleh kecelakaan lalu lintas. Faktor lingkungan seperti kondisi ruas jalan dapat menjadi pengaruh terjadinya kecelakaan lalu lintas. Sebagai salah satu daerah penyangga DKI Jakarta, Kota Depok memiliki salah satu akses jalan utama yaitu Jalan Margonda. Jalan tersebut merupakan salah satu tulang punggung dari kehidupan bermasyarakat serta menjadi penunjang bagi roda sosial dan perekonomian warga Kota Depok. Uji Laik Fungsi Jalan (ULFJ) merupakan pengujian atas syarat-syarat terkait suatu ruas jalan untuk memastikan bahwa jalan tersebut sudah layak untuk digunakan oleh pengendara dengan mementingkan aspek keselamatan. Oleh karena itu suatu jalan perlu untuk diuji tingkat kelayakannya secara berkala demi memastikan keamanan berkendara dan meminimalisir terjadinya kecelakaan. Evaluasi ULFJ sampai saat ini masih menggunakan pengisian formulir secara manual. Pada zaman dimana teknologi telah berkembang pesat, tentu dirasakan bahwa perlu adanya aplikasi otomasi untuk melakukan evaluasi ULFJ menggunakan algoritma.
Penilaian Kriteria Green Building Pada Gedung Pusat Layanan Haji dan Umrah Terpadu (PLHUT) Kota Langsa Berdasarkan Penilaian Greenship
Authors: Haikal M. , Sari Firda , Mutia Eka
Published: October 2023

Global warming is one of the things that causes environmental damage. Factors causing environmental damage include development that is not environmentally friendly, such as wasting energy, reducing green land, and others. The Green Building concept is one of the solutions to reduce global warming related to Civil Engineering buildings. The City of Langsa has recently rehabilitated the Integrated Hajj and Umrah Service Center (IHUSC) office, from a simple building to a 2-storey building, therefore the building has become the object of the author's research to assess how much the building has implemented the Green Building concept. The purpose of this study is to provide information regarding the value of the Green Building concept obtained by the Langsa City IHUSC building and provide advice regarding the suitability of implementing the Green Building concept in the IHUSC building so that it can be implemented as well as possible. The research steps use interview techniques and field observations and adapted to the Greenship assessment tool. Based on the results of the green building assessment, that have been carried out, the Langsa City Hajj and Umrah Service Center building received 43 points out of 117 maximum points. The Langsa City Integrated Hajj and Umrah Service Center building succeeded in obtaining a Bronze rating.

ABSTRAK

Pemanasan global adalah salah satu hal yang menyebabkan kerusakan lingkungan. Faktor-faktor penyebab kerusakan lingkungan tersebut diantaranya pembangunan yang tidak ramah pada lingkungan, seperti pemborosan energi, berkurangnya lahan hijau, dan lainnya. Konsep Green Building adalah salah satu solusi untuk mereduksi pemanasan global terkait bangunan Teknik Sipil. Kota Langsa baru saja merehabilitasi kantor Pusat Layanan Haji dan Umrah Terpadu (PLHUT), dari yang sebelumnya bangunan sederhana menjadi sebuah gedung yang memiliki 2 lantai, maka dari itu gedung tersebut menjadi objek penelitian penulis untuk menilai seberapa besar gedung tersebut sudah menerapkan konsep Green Building. Tujuan dari penelitian ini adalah memberikan informasi terkait nilai dari konsep Green Building yang diperoleh gedung PLHUT Kota Langsa dan memberikan saran terkait kesesuaian implementasi konsep Green Building pada gedung PLHUT agar dapat diterapkan sebaik-baiknya. Tahapan penelitian ini menggunakan suatu metode dengan teknik wawancara dan pengamatan di lapangan dan disesuaikan dengan perangkat penilaian Greenship. Berdasarkan dari hasil penilaian grren building, gedung PLHUT Kota Langsa memperoleh poin sebesar 43 dari 117 poin maksimal. Dengan demikian gedung PLHUT Kota Langsa berhasil memperoleh peringkat Perunggu.
Indonesian Purchasing Decisions Through E-Impulse Buying
Authors: Rediyono
Published: October 2023

This research aims to see to how far extent the user interface and user experience an impact on consumer have purchasing decisions through E-Impulse Buying. The correspondents of this study were IKIP PGRI Samarinda students who were active in online purchases through the Shopee application with a usage time of 0-6 years and between 18-24 years of age. The total sample is 131 respondents using purposive sampling method. Research data comes from questionnaires distributed using Google Forms or Manually. The data analysis technique uses path analysis through the SPSS 22 program. The results found show that the user interface and user experience have an impact on purchasing decisions directly, the user interface has an impact on purchasing decisions through E-Impulse Buying, and User Experience has no Impact on decisions purchase through E-Impulse Buying.
Pharmacological activities of parasitic plants of Loranthaceae – A review
Authors: Soundarya Venkatachalam , Karmegam Natchimuthu
Published: October 2023

Medicinal plants are the part of human Society to combat many disorders. The plant derived drugs and other herbal therapeutics are widely used against several malfunctions. Other than medicinal herbs, mistletoe–hemi parasitic plants are also used to treat many diseases. Usually, mistletoe family is recognized based on their host plants. Loranthaceae, the largest family in the order Santalales with 76 genera and more than 1,100 species. Most of the Loranthaceae family members are aerial parasites. Family comprises of 10 genera and 60 species which are found in India. It has been scientifically established that every part of these plants has medicinal properties (flower, stem, leaf, fruits, seed and whole plants). Only a few species are having potential traditional medicinal values and extensively used in several medicinal systems. Dendrophthoe falcata holds the major part in this taxon. This species shows traditional medicinal values in Indian Ayurvedic system of medicine and other systems of natural medicine widely. There are many biologically active components present in the parasitic plants, flavonoid, quercetin, kaempferol, rutin, tannins, β- sitosterol, stigmasterol, β- amyrin and oleanolic acid. Dendrophthoe falcata was rich in flavonoids and quercetin and the major components are reportedly present in the leaves. Quercitrin (quercetin 3-0-α- rhamnoside) has been separately isolated as a major component from the ethanolic extract of Dendrophthoe falcata leaves and this quercitrin phytochemical is highly responsible for antioxidative potency. Nanoparticles phytosynthesized from these plants are also studied for their pharmacological activities. It has been revealed that the medicinal properties of mistletoes based on host plants are scanty.
PERMAINAN KARTU SILA SEBAGAI ALTERNATIF MEDIA PEMBELAJARAN MATA PELAJARAN PKN KELAS IV DI SDIT ASSALAMAH UNGARAN
Authors: Wulandari Ristiana Suci , Suryani Riri Irma , Fauziah Emmareta
Published: October 2023

Tingkat keberhasilan pembelajaran salah satunya bergantung pada media pembelajaran yang digunakan. Diperlukan pemilihan media pembelajaran yang baik, efektif, dan tepat guna menghasilkan kualitas pembelajaran yang baik. Pada umunya, salah satu media pembelajaran yang paling efektif dan disukai oleh peserta didik yaitu kartu bergambar. Berdasarkan hasil wawancara dan observasi pada studi kasus di SDIT Assalamah Ungaran menunjukkan bahwa penggunaan media pembelajaran yang digunakan pada pembelajaran PKn Kelas IV belum maksimal dan efektif. Peserta didik sangat menantikan kehadiran media pembelajaran yang menghadirkan kebersamaan dengan teman-temannya dalam proses belajar. Dari permasalahan upaya meningkatkan keefektifan dan mengoptimalkan media pembelajaran pada Mata Pelajaran PKn, dirancang sebuah kartu media pembelajaran bertemakan nilai-nilai Pancasila sebagai media pembelajaran peserta didik. Metode yang digunakan adalah metode penelitian kualitatif yang bertujuan untuk menjelaskan dan mengetahui suatu masalah secara terperinci. Pendekatan yang digunakan dalam penelitian ini berupa deksriptif yang bertujuan agar peneliti bisa mendeskripsikan keadaan yang akan diamati di lapangan secara spesifik dan mendalam. Teknik pengumpulan data yang dilakukan untuk mendapatkan data penelitian menggunakan teknik observasi, wawancara, dan dokumentasi. Metode analisis data dalam penelitian ini menggunakan analisis SWOT. Kemudian konsep perancangan ini menggunakan teori Jesse Schell yang menjelaskan tentang mekanik, story, estetika, dan teknologi. Hasil dari perancangan ini adalah permainan kartu sebagai media utama yang dilengkapi dengan ilustrasi gambar penerapan nilai-nilai Pancasila dalam kehidupan sehari-hari sesuai dengan bunyi sila 1 sampai dengan sila 5. Kartu ini didukung dengan media pendukung berupa kemasan poster, topi, stand, dan sebagainya.
ASKARA: Jurnal Seni dan Desain
Authors: Seni dan Desain ASKARA Jurnal
Published: October 2023

Jurnal ASKARA merupakan media publikasi hasil penelitian ilmiah dalam bidang keilmuan seni visual, komunikasi visual dan desain yang lebih luas. Askara berupaya merepresentasikan dan berperan aktif dalam perkembangan wacana interdisiplin keilmuan, penelitian, dan publikasi keilmuan Desain Komunikasi Visual, Desain Produk dan Seni Visual secara umum, baik di lingkup akademis maupun praktisi.
Equations of state of the molten and crystalline phases of aluminum with deep entry into metastable regions
Authors: Mazhukin Vladimir Ivanovich , Demin Mikhail Mikhailovich , Shapranov Aleksandr Viktorovich , Koroleva Olga Nikolaevna , Mazhukin Alexander Vladimirovich
Published: October 2023

The article is devoted to the problem of constructing equations of state with deep entry into metastable regions (overheating/undercooling) of the molten and crystalline phases of aluminum. For mathematical modeling of hydrodynamic processes, the knowledge of the equations of state is the source of the most important information about the dependence of the thermodynamic properties of a substance on the microscopic internal structure. Moreover, for modeling, the equations of state are required in the form of smooth analytical dependencies with the characteristics of metastable states. Molecular dynamics simulation was used as the main tool for obtaining the equations of state. Based on the results of molecular dynamics calculations, the work obtained mutually consistent single-phase equations of state for molten and crystalline aluminum in tabular form. For tabular values, the approximating analytical dependences of low degrees were obtained. The results are presented in the form of tables and graphs. The thermodynamic consistency of the resulting equations is investigated. The simulation results of this work are compared with the equations of state for aluminum obtained by other authors.
THE DIFFICULTIES FACED AND THE STRATEGIES USED BY ENGLISH DEPARTMENT STUDENTS IN LEARNING ENGLISH AS A FOREIGN LANGUAGE
Authors: Muammalah Muammalah , Misnadin Misnadin
Published: October 2023

The study aims to identify the difficulties faced and the strategies used by English Department students at Universitas Trunojoyo Madura in learning English. The study used a mixed-method approach, which is a combination of quantitative and qualitative approaches. The source of data was one class in the second semester that consisted of thirty-seven students. The data were the difficulties faced by the students in learning English and the strategies they used to deal with them. The research instrument used was questionnaires containing both close-ended and open-ended questions. The data that was obtained from closed-ended questions were analysed quantitatively while those that were derived from open-ended questions were analysed qualitatively. The results showed that the difficulties faced by English Department students in learning English include pronunciation, grammar, and vocabulary and they exercised different strategies to solve them. Specifically, the strategies to solve the difficulty in learning pronunciation were listening to English songs, singing English songs, watching English movies or films, imitating using Google Translate, and practising the pronunciation by themselves. The strategies to tackle the difficulty in learning grammar were watching YouTube, reading English books, learning from the internet, learning through Instagram, and learning by themselves. Furthermore, there were several ways that they used to deal with the difficulty in learning vocabulary, for example, they used English dictionaries, watched English movies, read English books, used English songs, and memorized new vocabulary.
A systematic review of blunt abdominal aortic injury and analysis of predictors for death
Authors: Li Mingxuan , Wang Chaonan , Tu Haixia , Zhu Haitao , Guo Zhen , Guo Lianrui
Published: October 2023

At present, there are few studies on blunt abdominal aortic injury (BAAI), and most of them are case reports. Little is known about this disease. So, a systematic review was conducted through extensive search of major databases. All literature that provided individual (non-identifiable) data for BAAI patients could be included without being limited by study design. Additionally, regression analyses of predictors for death after BAAI were conducted. The search resulted in 2,099 hits, and 102 case reports and 1 conference abstract included in the review then. After assessment using the Joanna Briggs Institute checklist, no low-quality studies were found. A total of 133 patients were included, with a median age of 34 and 73.7% being males. Their most common clinical manifestation was pain (65.6%). The most common severity of aortic lesion was grade A (intimal tear or intramural hematoma, 46.9%), and the most common location of aortic lesion was zone III (infrarenal aorta, 88.3%). The overall mortality after BAAI was 15.3%. The following are the predictors for death after BAAI identified through multivariate regression analyses: lower limb ischemia [relative risk (RR), 7.137; 95% conﬁdence interval (CI), 1.154-44.161], cardiopulmonary arrest (RR, 10.250; 95% CI, 1.452-72.344), and injuries to other parts (other than abdomen and lumbar spine) of body (RR, 2.593; 95% CI, 1.189-5.655). In conclusion, this study provides a detailed quantitative summary of the characteristics of the clinical manifestations, diagnosis, treatment, and prognosis of BAAI, a deadly traumatic disease, and indicates that the three variables above are risk factors for death.
Pregnancy and neonatal outcomes in 25 pregnant women diagnosed with new-onset acute myeloid leukemia during pregnancy
Authors: Ding Jing , Xiao Yihan , Fu Jie , Liu Guoli , Huang Shanyamei , Mo Xiaodong
Published: October 2023

Purpose
The aim was to analyze the pregnancy and neonatal outcomes of pregnant women with new- onset acute myeloid leukemia (AML) diagnosed during pregnancy.
Methods
In this retrospective study 25 pregnant women who were diagnosed with new-onset AML during pregnancy from January 2010 to January 2021 were enrolled.
Results
A total of 4, 13 and 8 pregnant women with new-onset AML were diagnosed during the first, second, and third trimesters, respectively. Twelve of the 25 pregnant women underwent therapeutic abortion and 13 gave birth (9 preterm and 4 full-term newborns). The gestational age at initial clinical manifestations (13.4 ± 3.7 vs. 27.7 ± 5.6 weeks, P < 0.01) and diagnosis (16.9 ± 4.4 vs. 29.7 ± 5.5 weeks, P < 0.01) was lower in the pregnant women who underwent therapeutic abortion than in those who gave birth. Eighty-four percent (21/25) of the pregnant women with new-onset AML during pregnancy survived and were in remission and all the newborns were born alive. Three of the 13 newborns were exposed to chemotherapy, but no congenital malformations were observed. Eight newborns were admitted to the neonatal intensive care unit (NICU), and then all recovered. The complete blood counts and biochemical examinations of the 8 newborns were normal.
Conclusions
New-onset AML during an earlier stage of pregnancy may increase the risk of poor pregnancy outcomes. The neonatal outcomes of pregnant women with new-onset AML during pregnancy are good with proper treatment.
Solids Mixing Intensification in Tapered Fluidized Beds with an Inlet Jet: Experimental Validation and CFD Simulation
Authors: Jabbari Esmaeil , Mardanloo Peyman , Sarafan Kiana , Dehkordi Asghar Molaei
Published: October 2023

This article investigates the intensification of solids mixing in tapered fluidized beds with an inlet jet and varying apex angles (2.86, 5.71, and 8.53 degrees). The investigation applied a particle segregation number (PSN) and a multi-fluid modeling (MFM) approach. The solid mixtures considered comprise particles with a density of 2500 kg/m³ and diameters of 240 and 510 µm. To validate simulation results, a comparison was made with experimental data from a small-sized tapered bed without an inlet jet. In addition, the simulation outcomes were validated against experimental findings reported by Huilin et al. (2003), incorporating an inlet jet. These validations establish a satisfactory agreement between simulation results and experimental observations. The study reveals that the solids mixing process in a columnar fluidized bed closely resembles that in a tapered fluidized bed with an apex angle of 2.86 degrees. As the apex angle increases, the equilibrium mixing value also rises. Furthermore, the study delves into the effects of inlet jet velocity and nozzle diameter on the solids mixing process. The obtained results clearly indicate that higher inlet jet velocities and larger nozzle diameters lead to increased equilibrium mixing index values. Notably, inlet jet velocities of 0.7 and 0.8 m/s manifest a solids mixing process characterized by three stages: rapid mixing, slow mixing, and equilibrium mixing. In contrast, larger inlet jet velocities only involve rapid and equilibrium mixing stages. Moreover, it was examined how the initial arrangement of solid particles influences the mixing index, prompting appropriate adjustments. In sum, this research sheds light on the factors impacting solids mixing in tapered fluidized beds, offering valuable insights into the solids mixing process in tapered fluidized beds.
Design and Development of an Interactive Mobile-based Job Portal for Blue-collar and Migrant Workers in Thailand: A Design Thinking Approach
Authors: Pyae Aung , Saetoen Suparuek , Vanichayangkuranont Supatach
Published: October 2023

This report details the creation and usability of a web-based job portal designed exclusively for blue-collar and migrant workers in Thailand, potentially serving as a model for global application. Amidst an existing void of efficient job-seeking platforms in Thailand, these workers face hardships in securing suitable employment, often leading to mistreatment. Employing design thinking methodology, we discerned user needs, crafting a solution emphasizing user-friendliness and usability for those with limited technical proficiency. The platform presents clear job information, facilitating efficient searches. Comprising two interconnected web applications—one for job seekers and another for recruiters—this system underwent iterative design enhancements, receiving positive feedback from usability testing. Highlighting the essentiality of a user-centric design, this report underscores the platform’s potential to significantly improve employment prospects for these workers in Thailand. Moreover, the findings offer invaluable insights for similar global initiatives, aiming to mitigate employment challenges faced by blue-collar and migrant workers across various geographical and socio-economic contexts. The system’s model promotes the replication or adaptation of such user-centric job portals worldwide, aspiring to contribute towards more inclusive and equitable global labour market ecosystems. Through global adaptability, this project exemplifies a replicable blueprint in advancing job accessibility for blue-collar and migrant workers worldwide, thus advocating for broader systemic changes in the global labour market dynamics.
A Call for Increased Inclusivity and Global Representation in Pharmacogenetic Testing
Authors: Cohn Iris , Kennedy April , Ma Gabriel , Manshaei Roozbeh , Jobling Rebekah , Kim Raymond , Lewis Tamorah
Published: October 2023

Commercial pharmacogenetic testing panels capture a fraction of the genetic variation underlying medication metabolism and predisposition to adverse reactions. In this study we compared variation in five pharmacogenes detected by whole genome sequencing (WGS) to a targeted commercial panel in a cohort of 308 individuals with family history of pediatric heart disease. In 1% of the cohort, WGS identified rare variants that altered the interpretation of metabolizer status and would thus prevent potential errors in gene-based dosing.
A Comparison Between SAR Tomography and the Phase Histogram Technique for Remote Sensing of Forested Areas
Authors: Wu Chuanjun , Tebaldini Stefano , Yu Yanghai , Manzoni Marco , Liao Mingsheng
Published: October 2023

This paper compares two approaches for estimating forest height and vertical structure using synthetic aperture radar (SAR) data, namely the well-known SAR tomography (TomoSAR) technique and the recently introduced phase histogram (PH) technique. By jointly exploiting multiple SAR images, TomoSAR allows for direct imaging of the three-dimensional structure of the vegetation, from which biophysical parameters such as forest height and terrain topography can be extracted. The PH technique assigns each pixel in a SAR interferogram to a specific height bin based on the value of the corresponding interferometric phase, thus allowing for the estimation of the forest vertical structure by accumulating pixels magnitudes within a given spatial window. The two techniques are here compared on an experimental basis using L-Band tomographic data from the ESA campaign TomoSense, flown in 2020 at the Eifel Park in North West Germany. The analysis we present considers a characterization of forest scattering by 3D imaging and forest height retrieval. Experimental results indicate that the PH technique can only loosely approximate the vertical structure produced by SAR tomography. Still, it can produce a reasonably good estimate of forest height. In particular, TomoSAR and the PH technique are observed to have an average root mean square error (RMSE) with respect to Lidar estimate of 2.63 m and 4.35 m in North-West heading data, and 1.84 m and 5.46 m in South-East heading data, respectively. The observed results are interpreted in light of a simple physical model to characterize phase histograms depending on the number of scatterers within the SAR resolution cell, on which basis we derive analytical expressions to predict height dispersion in phase histograms. The conclusion from both experimental and theoretical results is that phase histograms cannot correctly reproduce forest structure, unless the distribution of scatterers within the SAR resolution cell is characterized by a single dominant scatterer. Consistently, we conclude that the PH technique is inherently best suited for the analysis of high- or very-high resolution data, which suggests its use in the context of higher frequency SAR Missions.
Свободно циркулирующая ДНК в плазме у пациентов с диффузной В-крупноклеточной лимфомой и В-клеточной лимфомой высокой степени злокачественности (‘double hit’/’triple hit’)
Authors: Смирнова Светлана Юрьевна , Никулина Е. Е. , Габеева Н. Г. , Королева Д. А. , Татарникова С. А. , Смольянинова А. К. , Гемджян Э. Г. , Звонков Е. Е. , Судариков А. Б.
Published: October 2023

Aim. To study plasma cell-free DNA (pcfDNA) concentration and B-cell clonality in patients with diffuse large B-cell (DLBCL) and B-cell high-grade lymphomas prior to and at different stages of chemotherapy as well as the correlation between the data obtained and clinical and laboratory parameters.

Materials & Methods. The study enrolled 23 DLBCL patients and 7 healthy donors (HD). Plasma was prepared from whole blood by centrifugation, pcfDNA was isolated with the commercial kit Qiagen (Germany). The concentration of pcfDNA was determined using fluorometer Qubit (USA). В-cell clonality was estimated by immunoglobulin gene analysis (BIOMED-2 protocol) in the tumor tissue and bone marrow core biopsy specimens obtained on diagnosis date as well as in the pcfDNA at 5 end points: prior to chemotherapy and after cycles 1, 2, 3, and 4.

Results. Prior to therapy, all DLBCL patients showed significantly higher pcfDNA concentration than HD. Immunochemotherapy cycle 1 resulted in considerable increase in pcfDNA concentration. After cycle 2 and subsequent cycles, pcfDNA concentration gradually decreased. After cycle 4, the mean pcfDNA concentration was comparable with that of HD. In 95 % of patients В-cell clonality in pcfDNA corresponded to that identified in the tumor specimen. After immunochemotherapy cycle 1, В-cell clonality was detected in 50 % of patients, after cycle 2 it was shown by 15 %. Only 1 female patient retained В-cell clonality after therapy cycles 3 and 4. In HD, no В-cell clonality in pcfDNA was identified. Prior to therapy, the analysis revealed no correlation of either pcfDNA concentration or В-cell clonality in pcfDNA with age, sex, tumor spread, presence or absence of extranodal lesions, proliferation index Ki-67, and lactate dehydrogenase concentration.

Conclusion. In patients with malignant hematological tumors, pcfDNA seems to be an interesting, easily accessible biological material deserving further investigation. Any studies of pcfDNA require long-term dynamical analysis and standardized methods of collection, storage and processing of the data obtained. In the long run, with more and more information, pcfDNA can become an important diagnostic marker of tumor heterogeneity and a reliable relapse predictor.
Fluorescent Coumarin-based Probe for Detection of Biological Thiols
Authors: Szwaczko Katarzyna
Published: October 2023

Nature-derived thiols such as cysteine, homocysteine, and reduced glutathione play
diverse and important roles in both plant and animal cells. In plants, they maintain redox homeostasis
and affect photosynthesis and signal transduction processes. In animals, changes in the levels
of biothiols have been linked to cardiovascular disease, Alzheimer's disease, neuropsychiatric
disorders, or stroke. The detection of biothiols in biological samples is, therefore, very important.
For this purpose, rapid, sensitive, and non-invasive methods for their sensing in living cells are
highly desirable.

:

This perspective reviews the past five years of advances in coumarin fluorescent probes for biothiol
detection. The design of the probes, the mechanisms of thiol detection, and the applications in live cell
imaging are presented. The classification of probes based on the coumarin backbone was made on the basis of
the mode of their interactions with the analyte.
Copper Oxide Supported on Silica (CuO/SiO2): A Highly Efficient Heterogeneous
Catalyst for the Synthesis of 1,2-Dihydroquinazolines at Room Temperature
Authors: Suri Mrinaly , Saikia Ujwal Pratim , Saikia Trishna , Namdeo Ashutosh , Pahari Pallab
Published: October 2023

A copper oxide supported on silica (CuO/SiO2) catalyst has been prepared which
catalyzes a three-component reaction between 2-aminobenzopenone, benzaldehyde, and ammonium
hydroxide leading to a convenient synthesis of 1,2-dihydroquinazoline. The main advantages
of the process over the previous reports are room temperature reaction, selective
formation of 1,2-dihydroquinazoline as a sole product, and recyclability of the catalyst. Seventeen
derivatives with various substituents are prepared. The catalyst (fresh and recovered) has
been fully characterized using HR-TEM, BET Surface area, XPS, FTIR, and XRD. The enhanced
activity and selectivity of the catalyst (towards 1,2-dihydroquinazoline) is attributed to
the formation of Cu-O-Si type surface structure which is also explained by the help of different
analytical techniques. Further, the reaction was performed without a catalyst, with CuO and SiO2 separately.
Based on catalyst characterization and experimental results a possible mechanism has been proposed
and discussed thoroughly. Recovery and reusability of the catalyst have also been studied.
A New Flavonoid Derivative and Inhibitory Effects on Xanthine Oxidase and
α-glucosidase from
Glinus oppositifolius
Authors: Hien Nguyen Thi Thu , Dung Huynh Tran Quoc , Minh Bui Hoang , Chen Tran Van , Tuan Nguyen Trong , Dung Le Tien
Published: October 2023

In previous studies on bioactivities, some extracts from Glinus oppositifolius possessed
antimicrobial, antifungal, antiplasmodial, anti-inflammatory, anti-diarrhoeic, antihyperlipidemic,
and hepatoprotective. However, information on the xanthine oxidase inhibitors’
properties of G. oppositifolius is still limited. For the purpose of discovering new leads with potential
α-glucosidase inhibition, the less explored plant G. oppositifolius has been investigated. A
new apigenin flavone glucoside, named apigenin-5-O-β-D-glucopyranosyl-8-C-β-Dglucopyranoside
(7), together with seven known compounds (spergulacin (1), glinoside C (2),
spergulacin A (3), spergulin B (4), spergulin A (5), vitexin (6), vicenin 2 (8)) were identified
from Glinus oppositifolius (L.) Aug. DC. aerial parts. The identification of their structures involved
a comprehensive analysis utilizing extensive 1D and 2D NMR techniques, mass spectrometry, and in
comparison with those from references. Compound 7 (IC50 =257.90 ± 1.00 μM) showed better inhibition of α-
glucosidase than acarbose (IC50 = 1021.47 ± 10.79 μM). Compound 8 (IC50 = 56.82 ± 1.95 μM) indicated a
good XO inhibitory effect.
Investigation of Antioxidant and Anti-inflammatory Properties of Berberine
Nanomicelles: In vitro and In vivo Studies
Authors: Heidarzadeh Marjan , Amininasab Mehriar , Rezayat Seyed Mahdi , Mousavi Seyyedeh Elaheh
Published: October 2023

Introduction:

In the present study, neuroprotective effects of berberine (BBR) and berberine
nanomicelle (BBR-NM) against lipopolysaccharides (LPS)-induced stress oxidative were investigated,
and compared by evaluating their antioxidant and anti-inflammatory activities in PC12 cells,
and rat brains. A fast, green, and simple synthesis method was used to prepare BBR-NMs.

Method:

The prepared BBR-NMs were then characterized using dynamic light scattering (DLS),
transmission electron microscopy (TEM), and scanning electron microscopy (SEM). In vitro experiments
were carried out on the LPS-treated PC12 cell lines to investigate the anti-cytotoxic and antioxidant
properties of BBR-NM and BBR. The results showed that BBR-NMs with a diameter of
~100 nm had higher protective effects against ROS production and cytotoxicity induced by LPS in
PC12 cells in comparison with free BBR.

Results:

Moreover, in vivo experiments indicated that the activity levels of antioxidant enzymes, such as
superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), increased in the brain
of LPS-treated rats administrated with BBR-NM at the optimum dose of 100 mg.kg-1. BBR-NM administration
also resulted in decreased concentration of lipid peroxidation (MDA) and pro-inflammatory
cytokines, such as Serum interleukin-1 beta (IL-1β) and tumor necrosis factor-alpha (TNF-α).

Conclusion:

Overall, BBR-NM demonstrated higher neuroprotective effects than free BBR, making
it a promising treatment for improving many diseases caused by oxidative stress and inflammation.
Phosphodiesterase Inhibitors of Natural Origin
Authors: Han Rui , Gaurav Anand , Mai Chun-Wai , Gautam Vertika , Gabriel Akyirem Akowuah
Published: October 2023

Phosphodiesterases (PDEs) function to hydrolyze intracellular cyclic adenosine monophosphate
(cAMP) and cyclic guanosine monophosphate (cGMP), regulating a variety of intracellular
signal transduction and physiological activities. PDEs can be divided into 11 families
(PDE1~11) and the diversity and complex expression of PDE family genes suggest that different
subtypes may have different mechanisms. PDEs are involved in various disease pathologies such
as inflammation, asthma, depression, and erectile dysfunction and are thus targets of interest for
several drug discovery campaigns. Natural products have always been an important source of bioactive
compounds for drug discovery, over the years several natural compounds have shown potential
as inhibitors of PDEs. In this article, phosphodiesterase inhibitors of natural origin have been
reviewed with emphasis on their chemistry and biological activities.
Effects of Cannabidiol in Adolescent and Young Adult Depressive
and Anxiety Disorders: A Systematic Review of Clinical and
Preclinical Research
Authors: Denson Rebecca K. , Brooks Julia , Pinna Graziano , Crane Natania A.
Published: October 2023

Background:

Adolescents and young adults may use cannabidiol (CBD)
products in an attempt to reduce depression and anxiety symptoms, despite little
research examining this use. This systematic review evaluated preclinical and clinical
research on the effects of CBD on depressive and anxiety disorders in adolescence and
young adulthood. To provide context, we discuss CBD’s mechanism of action and
neurodevelopmental effects.

Methods:

PubMed was searched for articles published through June 2022. Preclinical
or clinical CBD administration studies with N > 1 that examined depressive and/or
anxiety disorders were eligible.

Results:

Initially, 224 publications were identified. After excluding duplicates and
applying eligibility criteria, 6 preclinical (depression: n≈133; anxiety: n≈161) and 4
clinical (anxiety: n=113) articles remained. Due to the low number of studies, results
were synthesized qualitatively. The Oxford Centre for Evidence-Based Medicine 2011
Levels of Evidence were used to rate each study’s evidence. The preclinical effects of
CBD on depression-like behavior appear to differ by sex, early life stress, and duration
of use. Despite no evidence that CBD exerts anxiolytic effects in preclinical adolescent
models, CBD may reduce anxiety symptoms in human adolescents and young adults
with anxiety disorders.

Conclusion:

The existing evidence suggests that CBD may reduce symptoms of anxiety
in adolescents and young adults. However, the evidence is sparse and limited by
variations in samples and CBD dosing duration. Further research is needed to understand
the potential benefits and/or harms of CBD for depression and anxiety disorders in this
population. Implications for clinical practice and research are discussed.
Wearable Devices to Diagnose and Monitor the Progression of COVID-19 Through Heart Rate Variability Measurement: Systematic Review and Meta-Analysis
Authors: Sanches Carlos Alberto , Silva Graziella Alves , Librantz Andre Felipe Henriques , Sampaio Luciana Maria Malosa , Belan Peterson Adriano
Published: October 2023

Background

Recent studies have linked low heart rate variability (HRV) with COVID-19, indicating that this parameter can be a marker of the onset of the disease and its severity and a predictor of mortality in infected people. Given the large number of wearable devices that capture physiological signals of the human body easily and noninvasively, several studies have used this equipment to measure the HRV of individuals and related these measures to COVID-19.

Objective

The objective of this study was to assess the utility of HRV measurements obtained from wearable devices as predictive indicators of COVID-19, as well as the onset and worsening of symptoms in affected individuals.

Methods

A systematic review was conducted searching the following databases up to the end of January 2023: Embase, PubMed, Web of Science, Scopus, and IEEE Xplore. Studies had to include (1) measures of HRV in patients with COVID-19 and (2) measurements involving the use of wearable devices. We also conducted a meta-analysis of these measures to reduce possible biases and increase the statistical power of the primary research.

Results

The main finding was the association between low HRV and the onset and worsening of COVID-19 symptoms. In some cases, it was possible to predict the onset of COVID-19 before a positive clinical test. The meta-analysis of studies reported that a reduction in HRV parameters is associated with COVID-19. Individuals with COVID-19 presented a reduction in the SD of the normal-to-normal interbeat intervals and root mean square of the successive differences compared with healthy individuals. The decrease in the SD of the normal-to-normal interbeat intervals was 3.25 ms (95% CI −5.34 to −1.16 ms), and the decrease in the root mean square of the successive differences was 1.24 ms (95% CI −3.71 to 1.23 ms).

Conclusions

Wearable devices that measure changes in HRV, such as smartwatches, rings, and bracelets, provide information that allows for the identification of COVID-19 during the presymptomatic period as well as its worsening through an indirect and noninvasive self-diagnosis.
Immune-Boosting Effect of the COVID-19 Vaccine: Real-World Bidirectional Cohort Study (Preprint)
Authors: Liu Ming , Zhao Tianshuo , Mu Qiuyue , Zhang Ruizhi , Liu Chunting , Xu Fei , Liang Luxiang , Zhao Linglu , Zhao Suye , Cai Xianming , Wang Mingting , Huang Ninghua , Feng Tian , Lei Shiguang , Yang Guanghong , Cui Fuqiang
Published: October 2023

BACKGROUND

As the SARS-CoV-2 attenuates and antibodies from the COVID-19 vaccine decline, long-term attention should be paid to the durability of primary booster administration and the preventive effect of the second or multiple booster doses of the COVID-19 vaccine.

OBJECTIVE

This study aimed to explore the durability of primary booster administration and the preventive effect of second or multiple booster doses of the COVID-19 vaccine.

METHODS

We established a bidirectional cohort in Guizhou Province, China. Eligible participants who had received the primary booster dose were enrolled for blood sample collection and administration of the second booster dose. A retrospective cohort for the time of administration was constructed to evaluate antibody attenuation 6-12 months after the primary booster dose, while a prospective cohort on the vaccine effect of the second booster dose was constructed for 4 months after the second administration.

RESULTS

Between September 21, 2022, and January 30, 2023, a total of 327 participants were included in the final statistical analysis plan. The retrospective cohort revealed that approximately 6-12 months after receiving the primary booster, immunoglobulin G (IgG) slowly declined with time, while immunoglobulin A (IgA) remained almost constant. The prospective cohort showed that 28 days after receiving the second booster, the antibody levels were significantly improved. Higher levels of IgG and IgA were associated with better protection against COVID-19 infection for vaccine recipients. Regarding the protection of antibody levels against post–COVID-19 symptoms, the increase of the IgG had a protective effect on brain fog and sleep quality, while IgA had a protective effect on shortness of breath, brain fog, impaired coordination, and physical pain.

CONCLUSIONS

The IgG and IgA produced by the second booster dose of COVID-19 vaccines can protect against SARS-CoV-2 infection and may alleviate some post–COVID-19 symptoms. Further data and studies on secondary booster administration are required to confirm these conclusions.
Factors Associated With Perception of Stigma Among Parents of Children With Cleft Lip and Palate: Cross-Sectional Study (Preprint)
Authors: Zhang Yanan , Zhang Xinwen , Jiang Jinzhuo , Xie Wanhua , Xiang Daoman
Published: October 2023

BACKGROUND

Parents of children with cleft lip with or without cleft palate (CL/P) often face stigmatization, which has a significant impact on their quality of life and mental health. However, to date, there is a lack of comprehensive, multicenter empirical research on parents of children with CL/P in China, particularly those with large-scale samples.

OBJECTIVE

This study aimed to identify major factors that contribute to the perception of stigma experienced by parents of children with CL/P.

METHODS

A cross-sectional survey was conducted. A total of 104 parents of children diagnosed with CL/P in 2 hospitals were selected by convenience sampling. Demographics and disease information, the Chinese Perception of Stigma Questionnaire, the Center for Epidemiological Studies Depression Scale, and the Social Anxiety Scale were used in this study. Descriptive statistics, t tests, and one-way ANOVA were used to compare the differences between participants’ demographic information and perception of stigma. Multivariable linear regression was performed to assess associations between demographic factors, social anxiety, depression, and perception of stigma.

RESULTS

The mean scores for the dimensions of perception of stigma, depression, and social anxiety were 22.97 (SD 9.21), 38.34 (SD 8.25), and 22.86 (SD 6.69), respectively. Depression and social anxiety were positively associated with discrimination, while surgery status was a negatively associated variable. Parents with a college education or higher had significantly lower levels of perceived stigma compared to parents with a junior high school education (all P values <.05). These 4 factors explained 40.4% of the total model variance (F8=9.726; P<.001; R2=0.450; adjusted R2=0.404).

CONCLUSIONS

Our findings highlight a concerning trend of diminished quality of life among parents of children with CL/P. Factors such as parents’ education level, surgery status, depression, and social anxiety are shown to influence the level of stigma experienced. Implementing comprehensive nursing care and providing presurgical support are effective strategies for alleviating parents’ social anxiety, reducing perceived stigma, and preventing depression.
Effects of Lifestyle Interventions on Cardiovascular Disease Risk and Risk Factors Among Individuals at High Risk for Type 2 Diabetes: Protocol for a Systematic Review and Meta-Analysis of Randomized Controlled Trials (Preprint)
Authors: Demissie Getu Debalkie , Birungi Josephine , Haregu Tilahun , Thirunavukkarasu Sathish , Oldenburg Brian
Published: October 2023

BACKGROUND

Individuals at high risk for type 2 diabetes are also at an increased risk for developing cardiovascular disease (CVD). Although there are separate trials examining the effects of lifestyle interventions on absolute CVD risk among people at high risk for type 2 diabetes, a comprehensive evidence synthesis of these trials is lacking.

OBJECTIVE

We will systematically synthesize the evidence on the effects of lifestyle interventions in reducing absolute CVD risk and CVD risk factors among people at high risk for type 2 diabetes.

METHODS

We adhered to the PRISMA-P (Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols) statement in reporting the details of this protocol. Randomized controlled trials of diabetes prevention that examined the effects of lifestyle interventions for at least 6 months on absolute CVD risk and CVD risk factors among individuals at high risk for type 2 diabetes will be eligible. We will systematically search the MEDLINE, Embase, PsycINFO, CENTRAL, and Scopus databases and ClinicalTrials.gov using a mix of Medical Subject Headings and text words. Two authors will independently screen the abstract and title of the articles retrieved from the search, followed by full-text reviews using the inclusion and exclusion criteria and data extraction from the eligible studies. Article screening and data extraction will be performed in the Covidence software. The primary outcome will be the changes in absolute 10-year CVD risk, as estimated by risk prediction models. The secondary outcomes are the changes in CVD risk factors, including behavioral, clinical, biochemical, and psychosocial risk factors, and incidence of type 2 diabetes.

RESULTS

An initial database search was conducted in July 2023. After screening 1935 articles identified through the database search, 42 articles were considered eligible for inclusion. It is anticipated that the study findings will be submitted for publication in a peer-reviewed journal by the end of 2024.

CONCLUSIONS

This study will provide up-to-date, systematically synthesized evidence on the effects of lifestyle interventions on absolute CVD risk and CVD risk factors among individuals at high risk for type 2 diabetes.

CLINICALTRIAL

PROSPERO CRD42023429869; https://tinyurl.com/59ajy7rw

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/53517