bluuebunny/crossref_metadata_2025 huggingface dataset:
MRSA COLONITATION DETECTION IN OBJECT NEAR PATIENTS IN BURN UNIT RSUD DR. SOETOMO - INDONESIA
Authors: Wahyunitisari Manik Retno , Mustikasari Melisa Indah , Hariani Lynda
Published: August 2021

Background: Burn unit is a unit where patients with a burn wound in which the patient’s skin is not intact are taken care of. Methicillin-resistant Staphylococcus aureus (MRSA) as the prototype of a nosocomial pathogen is usually transmitted through contact from the surfaces of the object to the non-intact skin. Therefore, the possibility of MRSA infection increase in the burn unit. Purpose: The purpose of this research is to find out whether there is any colonization of MRSA on the objects around burn unit patients that can contribute to the spreading of MRSA in the RSUD Dr.Soetomo Indonesia. Method: The sampling period was started from October 2019 until March 2020. Samples were taken randomly from 28 patients in the Burn unit RSUD Dr.Soetomo -ndonesia and then tested for identification in the microbiology laboratory of the medical faculty, Universitas Airlangga. Result: Nineteen bacterial growths were obtained from twenty-eight samples taken, nine of them were confirmed as Stahylococcus aureus and one from nine of them was confirmed as MRSA. Conclusion: MRSA contamination was found on an object around the patient burn unit Dr. Soetomo-Indonesia which comes from the stethoscope membrane.
BLOOD SMEAR PROFILE OF PATIENTS WITH DENGUE HEMORRHAGIC FEVER IN BALI ROYAL HOSPITAL
Authors: Adnyana I Made Dwi Mertha , Sudaryati Ni Luh Gede , Suardana A.A Komang
Published: August 2021

Background: Each year, dengue hemorrhagic fever has grown. Clinical hematological examinations and blood preparations are used to confirm the diagnosis. Purpose: To detect, assess and characterize dengue hemorrhagic fever blood smear at Bali Royal Hospital. Method: Cross-sectional descriptive observational study-was conducted in April at Bali Royal Hospital on 37 patients with dengue hemorrhagic fever, clinical hematological tests and the manufacture of blood preparations identified using inclusion and exclusion criteria. Platelet counts, hemoglobin levels, hematocrit values, leukocyte counts, clinic degrees, gender and age, and blue plasma lymphocytes, are all used in hematological analyzed by univariate, ANOVA and BNT tests to analyze data. Result: Patients with dengue hemorrhagic fever are mostly toddlers and children (35.13%), women (54.0%), and dengue fever degree I (64.86%) with positive blue plasma lymphocytes (51.36%). Platelet counts, hemoglobin levels, hematocrit values, and leukocyte counts are significantly changed on days 3, 6, and 9, with probability values (p=0.000) less than p=0.01. The findings of the BNT test indicate that the number of platelets and haemoglobin on various days is significantly different (p<0.01), but the hematocrit value and leukocyte calculation are not significantly different (p>0.01). Conclusion: Clinical hematological tests and blood preparations reveal a blood component anomaly in Dengue Haemorragic Fever (DHF) patients at Bali Royal Hospital on days 3, 6, and 9.
Stop African swine fever (ASF): Public and private partnering for success. Report of the online event, 14–28 June 2021
Authors:   World Animal Health Organisation (OIE),   Food and Agriculture Organization of the United Nations (FAO)
Published: August 2021

The objectives of the ‘Stop ASF: Public and private partnering for success’ virtual event were to: • understand the impact of ASF on the public and private sectors; • identify the needs and common ground of all stakeholders regarding the effective control of ASF; • showcase how PPPs can help prevent and/or control ASF with proven efficiency and impact; • identify partnership opportunities, and current and future win–win scenarios; • promote the engagement of stakeholders and facilitate PPPs in the implementation of the ASF Global Initiative.
The Influence of Fiscal Decentralization, Economic Growth, and Economic Openness on the Inter-Provincial Development Disparity in Java During 2001-2017
Authors: Artaningtyas Wahyu Dwi , Winarti Asih Sri
Published: August 2021

In general, economic growth is defined as a process which leads to the increase of per capita income of a population in a long term. Inter-region disparity in terms of economic development is a common phenomenon in a region’s economic activities. This study aims to determine the effect of economic growth, economic openness, and the degree of fiscal decentralization on development disparities between provinces in Java within 2001-2017. Panel data regression was used together with the Random Effect Model as a data analysis technique. The data used was panel data consisting of time series data from 2001-2017 and cross-sectional data covering Special Capital Region of Jakarta, West Java, East Java, Special Region of Yogyakarta, Central Java, and Banten. The results show that economic growth and fiscal decentralization significantly influence development disparity between provinces in Java while economic openness does not affect the development inequality.
Effect of Macroeconomic Factors on The Small-Medium Enterprises Loans
Authors: Khariza Adhisty Mohammad , Arintoko Arintoko , Suprapto Suprapto
Published: August 2021

Small-medium enterprises (SMEs) are the main pillar of the Indonesian economy. Based on 2016’s Economic Census, most businesses in Indonesia are SMEs, while SMEs absorb the majority of the workforce. The empowerment of SMEs is one way to improve the economy. To empower the SMEs sector, the Indonesian government launched the Kredit Usaha Rakyat (KUR) since 2007. The lasts policy is the provision of the mild interest rate for KUR since 2016. The hope is that with a mild interest rate, SMEs can get affordable financing access so they can be the driving force of the economy. However, credit demand is not only influenced by interest rate but other macroeconomic factors such as Gross Domestic Product and inflation. Also, this study will look at how development disparities between the West Indonesia Region and East Indonesia Region affect credit demand. This research is intended to see the effect of macroeconomic factors on Small-medium enterprises loans. Source of data is taken from Indonesia Badan Pusat Statistik. Panel data use 2011-2018 time-series data and 33 provinces cross-section data are used to investigate the relationship of SMEs’ Loans with these macroeconomic factors. The result show that Interest Rate, GRDP, and Inflation, effect on SMEs Loans in a respectively different manner. However, the development disparities between West Indonesia Region and East Indonesia Region has no significant effect on SMEs’ loans. The study concludes that macroeconomic activities are important indicators not only the interest rate. So, the government should not only focus on interest rate policy but also other macroeconomic factors. Keyword: Macroeconomic Factors, SMEs’ Loan, Kredit Usaha Rakyat (KUR), Panel Data
Politeness Speech on Solidarity Scale-Based Manado Malay Speakers
Authors: Wengkang Thelma I. M. , Senduk Thomas M.
Published: August 2021

This study aims to describe the form and meaning of politeness speech on solidarity scale-based Manado Malay speakers. This study conducted in Manado city and used qualitative as a method. Observation and interviews were used as a technique of the study. The observation was used to observe the speakers of Manado Malay in using polite speech in daily social activities, whereas an interview was used by the researcher to questioning the informant about the use of polite speech in social interaction. This technique is complemented with listening, proficient, and note-taking techniques. The researcher plays a role as a key instrument who collects and analyzes the data. The source of data is the native speakers of Manado Malay who do interact in various places. Three informants who master Manado Malay were chosen. Techniques of analyzing data consist of 1) data reduction, simplified data collection, 2) data presentation, simplified data presented, categorized based on form and meaning, 3) verification, the data that has been presented were checked once more to ensure the accuracy according to the expected data, 4) conclusions, answering the predetermined problem formulations. The results showed that the social dimension, especially the solidarity scale, is a consideration for Manado Malay speakers in realizing polite speech, as well as when to use informal variants and when to use formal ones. The relationship among speakers has made them create the appropriate language choices, but language ethics that embody politeness remain a consideration. In various social interactions, occupations, religious meetings, associations, and family interactions, it turns out that Manado Malay people realize the politeness of speaking by changing command sentences into declarative sentences and asking along with the use of a flat intonation when speaking. The consideration of solidarity is the reason they speak politely, in addition to the status and formality scale.
Using Character Education Forms and Values of Folklores in Brebes Regency as the Old Literature Learning Materials
Authors: Setiani Umi Ana , Sukirno Sukirno , Riyanton M. , Kariadi Mustasyfa Thabib
Published: August 2021

This research aimed at analyzing the character education forms and values contained in the folklores of Brebes Regency including their relevance for the old literature learning materials at higher education institutions. This research used a qualitative method with an ethnographic approach. The data were collected using an observational study, in-depth interview, note-taking, and documentation. The results show that the folklores in Brebes Regency are in the form of legends and myths. Besides, the folklores of Brebes Regency also contain 13 educational character values consisting of religiousness, hard-working, nationalism and patriotism, appreciating achievements, friendly/communicative, environmental awareness, responsibility, curiosity, discipline, democracy, honesty, tolerance, and social awareness value. Thus, the folklores of Brebes Regency are considered relevant to use as the old literature learning materials at higher education institutions since they are not only appropriate and functional in providing adequate experiences for the students but also containing noble values to follow.
IMPLEMENTASI MODEL REGRESI LOGISTIK MULTINOMIAL PADA PENGELOMPOKAN PENYAKIT TUBERKULOSIS
Authors: Apriyani Mella , Jajang Jajang , Sb. Agustini Tripena Br.
Published: August 2021

There are three types of  Tuberculosis (TB) patients at Banyumas Region Hospital, namely negative  pulmonary TB, positive pulmonary TB, and extra pulmonary TB. Types of TB generally caused by age, cae of history, gender, level of education, and domicile. One of the methods that used to find a correlation between types of TB with the affect is regression analysis. This study used multinomial logistic regession analysis because types of TB is categorical and the data is 156 TB’s patients recorded at 2018/2019. The result showed that the level of education be a dominant factor to affect TB. Here, we noted that patients with basic education level have a 5,843 time odds for getting positive pulmonary TB and 2,224 times for getting extra pulmonary TB. The multinomial logistic regression model is then given as probability for getting positive pulmonary TB with factor level of education is greather than negative pulmonary TB and extra pulmonary TB.
PEMODELAN KEBUTUHAN GIZI PADA BALITA DENGAN ARTIFICIAL NEURAL NETWORK
Authors: Jajang Jajang , Meilani Sylvia
Published: August 2021

An information on the data is not easily obtained if the data is not presented well. The nutritional needs of toddlers are important to be studied to get an information about growth of these toddlers. This research studied the nutritional needs and its factors by using Artificial neural networks (ANN) model.  These factors are toddler's age, gender, weight, height, activity.  Nutrition data for children under five years old was obtained from interviews at 47 Posyandu locations.  The results showed that the resulting ANN model gave quite good results where the error value generated was 0.024
Identification and activity of active compound of bamboo leaves (Bambusa vulgaris Schrad ex.J.C) ethanolic extract against diabetic ulcers gram-negative bacteria from diabetic ulcer’s patient
Authors:   Departement of Pharmacy Faculty of Medicine Tanjungpura University, Apridamayanti Pratiwi
Published: July 2021

Background: Bamboo leaves (Bambusa vulgaris Schrad ex.J.C) are plants that are known to have pharmacological activity, one of which is to have antibacterial activity. Diabetic Foot Ulcers (DFU) is one chronic complication of diabetes mellitus. DFU is open sores on the surface of the skin that can be accompanied by local tissue death. Infection that is not appropriately treated in patients can cause amputation. Improper use of antibiotics can cause resistance events. A resistance that occurs in Proteus mirabilis, Pseudomonas aeruginosa, and Escherichia coli in isolates from DFU patients encourages researchers to look for alternative antibiotics from natural resources. Objective: Determine the profile of secondary metabolites by thin-layer chromatography, foam index, total phenols, total flavonoids and the antibacterial activity of bamboo (B. vulgaris) through the antibacterial with clear zone value of bamboo leaf ethanol extract against bacteria E. coli, P. aeruginosa, and P. mirabilis. Method: Phenol, flavonoid, and triterpenoid test using TLC method. Saponin tests were carried out using foam index, fish index, and hemolytic index test methods. Total flavonoid testing using Chang method and total phenol method using the Follin Ciocalteau reagent then proceed using a spectrophotometer. Test the antibacterial activity using the agar diffusion method. Results: Chromatographic profile, phenol, flavonoid, and triterpenoid compounds were obtained; saponin index obtained foam index of 333; fish index of 200; and the hemolytic index of 1,111. The total phenol test was 16.052 ± 3.12 % and the total flavonoid was 2.42 ± 0.44 %. Antibacterial activity test obtained MIC values of 60 mg/ml for E. coli bacteria; 100 mg/ml for the bacterium P. aeruginosa; and 30 mg/ml of P. mirabilis. Conclusion: The content of secondary metabolites found in the ethanol extract of bamboo leaves were flavonoid, phenol, saponin and triterpenoids. Ethanol extract of bamboo leaves has a the potential to produce antibacterial activity against gram-negative pathogenic bacteria isolated from diabetic wound patients Keywords: Bambusa vulgaris Schrad ex.J.C, total phenol, total flavonoid, MIC
Evaluasi penyimpanan obat di Puskesmas "X" Kabupaten Sleman
Authors:   Department of Pharmacy, Universitas Islam Indonesia, Rugiarti Novi Dwi , Hidayati Atika Nurul , Medisa Dian , Nugraheni Diesty Anita ,   Department of Pharmacy, Universitas Islam Indonesia
Published: July 2021

Background: Evaluation of drug storage in a primary health care is an important process in drug management. Evaluation use with indicators. Some of indicators are Percentage of expired date drugs, percentage of stockout and Turn Over Ratio (TOR). Objective: This study aimed to know the efficiency of drug storage in Mlati II primary health care Methods: This observation research use retrospective data. Results: Percentage of expired date drugs was 2.45% and percentage stockout was 2.45% and Turn Over Ratio was 5.2 times Conclusion: Drug storage has not efficient yet. Keywords: Evaluation, drug storage, primary health care
An Evaluation of SVM in Hand Gesture Detection Using IMU-Based Smartwatches for Smart Lighting Control
Authors: Ameliasari Maya , Putrada Aji Gautama , Pahlevi Rizka Reza
Published: August 2021

Hand gesture detection with a smartwatch can be used as a smart lighting control on the internet of things (IoT) environment using machine learning techniques such as support vector machine (SVM). However, several parameters affect the SVM model's performance and need to be evaluated. This study evaluates the parameters in building an SVM model for hand gesture detection in intelligent lighting control. In this study, eight gestures were defined to turn on and off four different lights, and then the data were collected through a smartwatch with an Inertial Measurement Unit (IMU) sensor. Feature selection using Pearson Correlation is then carried out on 36 features extracted from each gesture data. Finally, two sets of gestures were compared to evaluate the effect of gesture selection on model performance. The first set of gestures show that the accuracy of 10 features compared to the accuracy of 36 features is 94% compared to 71%, respectively. Furthermore, the second set of gestures has an accuracy lower than the first set of gestures, which is 64%. Results show that the lower the number of features, the better the accuracy. Then, the set of gestures that are not too distinctive show lower accuracy than the highly distinctive gesture sets. The conclusion is, in implementing gesture detection with SVM, low data dimensions need to be maintained through feature selection methods, and a distinctive set of gesture selection is required for a model with good performance.
Production of a Potentially Probiotic Product for Animal Feed and Evaluation of Some of Its Probiotic Properties
Authors: Agregán-Pérez Rubén , Alonso-González Elisa , Mejuto Juan Carlos , Pérez-Guerra Nelson
Published: August 2021

Nowadays, probiotics has been proposed for substituting antibiotics in animal feed, since the European Union (EU) banned the latter compounds in 2006 to avoid their serious side effects on human health. Therefore, this work aimed to produce a probiotic product by fed-fermentation of whey with kefir grains for use in animal feed. The whey was fermented with a combination of kefir grains AGK1 and the free biomass present in whole milk fermented milk used to activate these kefir grains. The probiotic culture obtained was characterized with high levels of biomass, total viability and antibacterial activity. Some probiotic properties of the probiotic culture were investigated in vitro, including its survival at low pH values, under simulated gastrointestinal conditions, after freezing in skim milk at − 20 ºC, and in the commercial feed during storage at room temperature. The viable cells of lactic and acetic acid bacteria and yeasts exhibited higher tolerance to acidic pH and simulated gastrointestinal conditions when the cells were protected with skim milk and piglet feed, compared with washed cells. The results indicated the feasibility of producing a probiotic product at a low cost with a potential application in animal feed.
Are mHealth a Useful Tool for Self-Assessment and Rehabilitation of People With Multiple Sclerosis? A Review
Authors: Bonnechère Bruno , Rintala Aki , Spooren Annemie , Lamers Ilse , Feys Peter
Published: August 2021

The development of mobile technology and internet mobile offers new possibilities in both rehabilitation and for patients’ assessment in a longitudinal and MS management perspective. However, because the mobile health applications (mHealth) have only been developed recently, the level of evidence supporting the use of mHealth in patients with multiple sclerosis (pwMS) is currently unclear. Therefore, this study aims to list and describe the different mHealth available for rehabilitation and self-assessment of pwMS and to define the level of evidence supporting these interventions for functioning problems categorized within the International Classification of Functioning, Disability and Health (ICF). 36 studies, performed with 22 different mHealth, were included in this review, 30 about rehabilitation and 6 for self-assessment, representing 3,091 patients. For rehabilitation, most of the studies were focusing on cognitive function and fatigue. Concerning the efficacy we found a small but significant effect of the use of mHealth for cognitive training (SMD = 0.28 [0.12 ; 0.45]) and moderate effect for fatigue (SMD = 0.61 [0.47 ; 0.76]). mHealth is a promising tool in pwMS but more studies are needed to validate these solutions in the others ICF categories. More replications studies are also needed as most of the mHealth have only been assessed in one single study.
Effect of Total Starch and Resistant Starch in Commercial Extruded Dog Foods on Gastric Emptying in Non-Racing Sled Dogs
Authors: Richards Taylor L. , Rankovic Alexandra , Cant John P. , Shoveller Anna K. , Adolphe Jennifer L. , Ramdath Dan , Verbrugghe Adronie
Published: August 2021

Gastric emptying rate (GER) may impact diabetes and obesity in humans and could provide a method to reduce canine weight gain. Starch, the most common source of carbohydrates (CHOs) in pet food, is classified as rapidly or slowly digestible, or resistant to digestion. This study investigated starch source effects in commercial extruded dog foods on the GER of 11 healthy adult Siberian Huskies (5.63±0.72 years; mean±SEM). Test diets were classified as traditional, grain-free, whole-grain, and vegan. Dogs received each diet once, a glucose control twice, and acetaminophen (Ac) as a marker for GER in a randomized, partially-replicated, 6x6 Latin square design. Pre- and post-prandial blood samples were collected at 16 timepoints from -15 to 480 minutes. Serum Ac concentrations were assessed via standard spectrophotometric assays and fitted with a mathematical model to estimate parameters of GER. Data was analyzed using a repeated measures ANOVA, followed by a Tukey-Kramer post-hoc test when significant (p<0.05). More total emptying (p= 0.0430) occurred at faster rate (p=0.0668) in dogs fed the grain-free diet, which contained the lowest total starch (34.03 ± 0.23%) and highest resistant starch (0.52 ± 0.007%). This research may benefit future diet formulations to reduce the prevalence of canine weight gain.
Olfactory Learning Supports an Adaptive Sugar-Aversion Gustatory Phenotype in the German Cockroach
Authors: Wada-Katsumata Ayako , Schal Coby
Published: August 2021

An association of food sources with odors prominently guides foraging behavior in animals. To understand the interaction of olfactory memory and food preferences, we used glucose-averse (GA) German cockroaches. Multiple populations of cockroaches evolved a gustatory polymorphism where glucose is perceived as a deterrent and enables GA cockroaches to avoid eating glucose-containing toxic baits. Comparative behavioral analysis using an operant conditioning paradigm revealed that learning and memory guide foraging decisions. Cockroaches learned to associate specific food odors with fructose (phagostimulant, reward) within only a 1 hr conditioning session, and with caffeine (deterrent, punishment) after only three 1 hr conditioning sessions. Glucose acted as reward in wild type (WT) cockroaches, but GA cockroaches learned to avoid an innately attractive odor that was associated with glucose. Olfactory memory was retained for at least 3 days after three 1 hr conditioning sessions. Our results reveal that specific tastants can serve as potent reward or punishment in olfactory associative learning, which reinforces gustatory food preferences. Olfactory learning therefore reinforces behavioral resistance of GA cockroaches to sugar-containing toxic baits. Cockroaches may also generalize their olfactory learning to baits that contain the same or similar attractive odors even if they do not contain glucose.
Telemonitoring of Real-World Health Data in Cardiology: A Systematic Review
Authors: Kinast Benjamin , Lutz Matthias , Schreiweis Björn
Published: August 2021

(1) Background: New sensor technologies in wearables and other consumer health devices open up promising opportunities to collect real-world data. As cardiovascular diseases remain reason number one for disease and mortality worldwide, cardiology offers potent monitoring use-cases with patients in their out-of-hospital daily routine. Therefore, the aim of this systematic review is to investigate the status quo of studies monitoring patients with cardiovascular risks and patients suffering from cardiovascular diseases in a telemedical setting using not only a smartphone-based app, but also consumer health devices such as wearables and other sensor-based devices. (2) Methods: A literature search was conducted across five databases and the results were examined according to the study protocols, technical approaches and qualitative and quantitative parameters measured. (3) Results: Out of 166 articles, 8 studies were included in this systematic review. These cover interventional and observational monitoring approaches in the area of cardiovascular diseases, heart failure and atrial fibrillation using various app, wearable and health device combination. (4) Conclusions: Depending on the researcher’s motivation a fusion of apps, patient reported outcome measures and non-invasive sensors can be orchestrated in a meaningful way adding major contributions to monitoring concepts for both, individual patients and larger cohorts.
Middle Ear Packing and External Ear Packing with Fibrin Glue Enhances the Success of Fat Myringoplasty without Hyaluronic Acid Disc
Authors: Kim Jongmin , Jang Chul Ho
Published: August 2021

Background: To date, FM using middle ear packing has rarely reported. In this study, we hypothesized that middle ear packing with dexamethasone soaked gelfoam and fibrin glue over the fat graft could promote the success rate of TMP closure regardless of perforation size. Methods: Between January 2005 and July 2020, a total of 209 patients who underwent fat myringoplasty due to chronic TMP at tertiary referral center were encountered and analyzed. The success rate and audiologic outcome was analyzed. Results: The mean successful TM closure rate was 88.0 %. The success rate by different age generation was not significant difference. The size of the perforation grade showed no significant difference. The perforation site by anterior or posterior was not significant. The preoperative mean threshold of AC, BC and ABG were 55.71, 12.98 and 42.73 dB respectively. The postoperative mean threshold of AC, BC and ABG were 23.67, 12.98 and 10.69 dB. The change of preoperative and postoperative hearing showed statistically significant. Conclusion: From our results, the simple trimming of the perforation edge and middle ear packing with external ear canal packing using fibrin glue induced the stable adhesion between the remnant TM and the fat graft.
Anticancer Activity and Structure Activity Relationship of Non-Symmetrical Choline Kinase Inhibitors
Authors: Schiaffino-Ortega Santiago , Mariotto Elena , Luque-Navarro Pilar María , Kimatrai-Salvador María , Hurtado-Guerrero Ramon , Rios-Marco Pablo , Marco Carmen , Carrasco-Jimenez María Paz , Viola Giampietro , López-Cara Luisa Carlota
Published: August 2021

Choline kinase inhibitors are an important class of cytotoxic compounds useful for the treatment of different forms of cancer since aberrant choline metabolism is a feature of neoplastic cells. Here we present the characterization and the structure activity relationship of a series of non-symmetrical choline kinase inhibitors characterized by a 3-aminophenol moiety, bound to 4-(dimethylamino)- or 4-(pyrrolidin-1-yl)pyridinium cationic heads through several linkers. These derivatives were evaluated both for their inhibitory activity on the enzyme and for their antiproliferative activity in a panel of six human tumor cell lines. The compounds with the best inhibitory results were those connected to the linker by the N-atom (4a-h) and these results are supported by docking studies. The compounds with the best antiproliferative results were those connected to the linker by the O-atom (3a-h). On the other hand, as was predictable in both families, the inhibitory effect on the enzyme is greater the shorter the length of the linker, while in tumor cells, lipophilicity and choline uptake inhibition could play a decisive role. Interestingly compounds 3c and 4f, selected for both their ability to inhibit the enzyme and good antiproliferative activity, are endowed with a low toxicity in non-tumoral cells (e.g human peripheral lymphocytes) respect to cancer cells. These compounds were also able to induce to induce apoptosis in Jurkat leukemic cells without causing significative variations of cell cycle. It is worth to mention that these derivatives, beside their inhibitory effect on choline kinase, displayed a modest ability to inhibit choline uptake thus suggesting that this mechanism may also contribute to the observed cytotoxicity.
Fluorescent Analysis Reveals that Insulin Diminishes Superoxide Increase in Neurons Induced with Toxic Glutamate Treatment
Authors: Pinelis Vsevolod G. , Krasil'nikova Irina , Bakaeva Zanda , Surin Alexander M. , Fisenko Andrey P. , Boyarkin Dmitry , Krasilnikova Olga A. , Pomytkin Igor A.
Published: August 2021

Glutamate excitotoxicity is implicated in the pathogenesis of many disorders, including stroke, traumatic brain injury, and Alzheimer’s disease, for which central insulin resistance is a comorbid condition. Massive glutamate release primarily through ionotropic N-methyl-D-aspartate receptors (NMDARs) causes a sustained rise in [Ca2+]i, followed by mitochondrial depolarization and an increase in intracellular O2• (superoxide) production. Recently, we found that insulin protected neurons against excitotoxicity by diminishing the delayed calcium deregulation (DCD), However, a role of insulin in superoxide production in excitotoxicity still needs to be clarified. The present study is aimed to investigate the effects of insulin on glutamate-evoked superoxide generation and DCD using the fluorescent indicators dihydroethidium, MitoSOX Red, and Fura-FF in rats cultured cortical neurons. We found that insulin significantly diminished both the intracellular and mitochondrial superoxide production in neurons exposed to glutamate and there was a strong linear correlation between [Ca2+]i and intracellular superoxide. MK 801, an inhibitor of NMDAR-gated Ca2+ influx, completely abrogated the glutamate effects in both the presence and absence of insulin. In experiments on sister cultures, insulin diminishes neuronal death. Thus, collectively, data obtained suggest that insulin diminishes glutamate-induced superoxide production in neurons via fall of [Ca2+]i increased and thereby improves viability of neurons
Analysis of empathetic tendencies and conflict management strategies of teachers working abroad
Authors: Mafratoğlu Perihan , Yalçinkaya Münevver
Published: July 2021

In this research, empathetic tendencies and conflict management strategies of teachers that were appointed by the Ministerial Common Culture Commission to work in the Northern Cyprus Turkish Republic (TRNC) while still working in schools governed by the Republic of Turkey Ministry of National Education within the scope of overseas assignments were investigated according to various different variables. The universe of this research consists of 189 teachers working in different levels and types of schools in the TRNC. In the study, no sample selection was made, but rather it was aimed to reach the entire universe. This research is a descriptive quantitative study that has been studied with the relational scanning model. “Empathetic Tendency Scale” and “Conflict Management Strategies Scale” were used as data collection tools in the study. The research data were analyzed with SPSS Statistics 24 program, t test; One Way Analysis of Variance, Tukey HSD and Pearson Correlation were applied. In the analysis of the data, the significance level was determined as .05. As a result of the research, it was determined that there is a significant difference in favor of women in terms of the gender variable in the empathetic tendency levels of the teachers working abroad. It was found that there is a significant difference in favor of teachers aged 41 and over in the compliance strategy among the conflict management strategies used by teachers. In addition, it was found that the teachers who participated in the research used the strategy of integration the most and the avoidance strategy the least; it was found that there was a significant relationship between teachers' empathetic tendencies and strategies of integration, compromise, compliance, and domination.
DECONSTRUCTING HOLLYWOOD WAR CINEMA: THE CONSTRUCTION OF THE ENEMY IN INGLORIOUS BASTERDS AS POSTMODERN ENEMY
Authors: Sauci Kholifatul
Published: July 2021

This research examines the construction of the enemy in Quentin Tarantino's Inglourious Basterds (2009) as postmodern enemy through the portrayal of the Nazi. Applying Derrida's deconstruction theory to see how Hollywood cinematic convention is being deconstructed, the analysis shows that the Nazi are being deconstructed through the following construction: 1) wearing distinctive outfit, 2) being dehumanized as evil, 3) having different purpose from the hero, 4)being on the losing side, and 5) being racially different. The Nazi shows some qualities of not being stereotypical enemy: they are depicted to show patriotism, loyalty, and compassion. The blurry characteristics between hero and enemy shows postmodernity.
THE DEPICTION OF HEGEMONY CREATED AND DEVELOPED BY THE GROUP OF THE PIGS IN ORWELL’S ANIMAL FARM
Authors: Arifriarni Kenanga Fajar
Published: July 2021

Power is one of the most wanted things in this world. Many people compete with each other for power. Sometimes, some of them use their cunning to accomplish their desire for power. When they succeed to get it, they will do everything to maintain their positions. This research explores those kinds of issues portrayed in George Orwell’s novel entitled Animal Farm (1945). Furthermore, the research focuses on the process of how hegemony takes place in Animal Farm. Antonio Gramsci’s theory about hegemony is used to analyze the data. The research finds out that from the beginning to the end of the story, Orwell’s Animal Farm shows the system of hegemony created and developed by the pigs’ group. Old Major’s speech made the animals realized their real condition and triggered the animals to rebel against their master, Mr. Jones. Even though their rebellion succeeded to expel Mr. Jones and his men from the farm, it emerged the new supremacy of the pigs. Snowball only used consent to rule the animals. On the other hand, Napoleon used the combination of consent and coercion to rule the animals.
The INFLUENCE OF COUNTRY-OF-ORIGIN AND BRAND IMAGE ON PURCHASE INTENTION OF OPPO SMARTPHONE WITH PERCEIVED QUALITY AS INTERVENING VARIABLES
Authors: Setyo Aji Wibowo  , Mohamad Rizan  , Ika Febrilia
Published: July 2021

The purpose of this study was to examine the effect of country-of-origin and brand image on purchase intention through perceived quality as a variable intervening. The approach used in this research is a quantitative approach and data collection methods using survey method. Respondents in this study were students of the State University of Jakarta who had or are currently using Oppo smartphone. Where, in this study, 216 respondents were obtained from various faculties at the State University of Jakarta. The processed data is then used to test seven hypotheses using Structural Equation Modeling (SEM). The results of this study are: first, country-of-origin has a positive and significant effect on perceived quality; second, brand image has a positive and significant effect on perceived quality; third, country-of-origin has no significant effect on purchase intention; the fourth, brand image has no significant effect on purchase intention; fifth, perceived quality has a positive and significant effect on purchase intention; sixth, perceived quality can be a mediating variable on the relationship between country-of-origin and purchase intention; seventh, perception quality can be a mediator variable on the relationship between brand image and purchase intention.

Keywords: Country-of-Origin, Brand Image, Perceived Quality, Purchase Intention, Oppo Smartphone
THE INFLUENCE OF EMPLOYEE ENGAGEMENT AND JOB SATISFACTION ON ORGANIZATIONAL CITIZENSHIP BEHAVIOR AT PT. RIZKI ASA BUANA
Authors: Azzam Imaduddin al azzam , Widya Parimita  , Christian Wiradendi Wolor
Published: July 2021

The objectives of this study are: 1) To find out the description of work engagement, job satisfaction and Organizational Citizenship Behavior (OCB) for employees of PT. Rizki Asa Buana on Jl. Manggul jaya no.9 (base 4) cikiwul, bantar gebang. Bekasi 17152. 2) To determine the effect of Work Engagement on Organizational Citizenship Behavior (OCB) on employees of PT. Rizki Asa Buana on Jl. Manggul jaya no.9 (base 4) cikiwul, bantar gebang. Bekasi 17152. 3) To determine the effect of Job Satisfaction on Organizational Citizenship Behavior (OCB) on employees of PT. Rizki Asa Buana on Jl. Manggul jaya no.9 (base 4) cikiwul, bantar gebang. Bekasi 17152. 4) To find out how much the contribution of Job Engagement and Job Satisfaction to Organizational Citizenship Behavior (OCB) for employees of PT. Rizki Asa Buana on Jl. Manggul jaya no.9 (base 4) cikiwul, bantar gebang. Bekasi 17152. This research was conducted on 135 employees of PT. Rizki Asa Buana on Jl. Manggul jaya no.9 (base 4) cikiwul, bantar gebang. Bekasi 17152. The data collection technique used survey and interview methods, namely by interviewing employees one by one and distributing questionnaires which were then processed using the SPSS program. This research uses descriptive and explanatory analysis. The results obtained from the regression show that there is a positive and significant influence between Work Engagement on Organizational Citizenship Behavior and a positive and significant influence between Job Satisfaction on Organizational Citizenship Behavior and the research model of Job Engagement and Job Satisfaction can predict Organizational Citizenship Behavior in Pt. Rizki Asa Buana which is on Jl. Manggul jaya no.9 (base 4) cikiwul, bantar gebang. Bekasi 17152 with a value of Fcount> Ftable (62.091> 2.70) and significance (0.000 <0.05).

Keyword: Employee Engagement, Job Satisfaction, Organizational Citizenship Behavior (OCB).
THE EFFECT OF E-SERVICE QUALITY AND PERCEIVED PRICE FAIRNESS ON CUSTOMER LOYALTY WHICH CUSTOMER SATISFACTION AS INTERVENING STUDY ON ONLINE SHOPPING SITE IN INDONESIA
Authors: Olivia Citra Octaviani  , Mohamad Rizan  , Agung Kresnamurti Rivai P
Published: July 2021

This study examines the effect of e-service quality and perceived price fairness on customer loyalty with the intervening role of customers’ satisfaction in the online shopping site in Indonesia. The research method uses a quantitative research design with a survey model. The sample used in this study is Lazada consumers which consists of five large cities in Indonesia (Jakarta, Bogor, Depok, Tanggerang, and Bekasi City) and have done online shopping site at Lazada at least once in the last six months. The object of this research were the 200 customer respondents who had made purchases on the largest online shopping site platform of Indonesia, Lazada. Data analysis was done by using SPSS and Structural Equation Modeling (SEM). The results show that: first, the e-service quality and perceived price fairness affect customer satisfaction positively. Second, there is a mediating effect of customer satisfaction on the relationship between e-service quality and perceived price fairness on customer loyalty. Third, e-service quality and perceived price fairness directly affect customer loyalty positively but insignificantly. The result implies that the role of customer satisfaction is significant in creating loyalty. In the online shopping site a  good quality and perception about price could positively influence customers but not necessarily form loyalty.
Prevention Practices and Legal Rules for Handling Pandemics in The Prophetic Sirah
Authors: Hafidi Hakima , Mauhub Fauzi
Published: August 2021

This study focuses on highlighting the devotional and social preventive applications related to the epidemics, by shedding the lights on some stations from the biography and the sunnah of the Prophet peace be upon him, this will contribute to the prevention of epidemics, especially Coronavirus, by following the teaching of Sharia and the approach of the Prophet, peace be upon him, in dealing with such types of epidemics that appeared in his era. To achieve the goal of this study, we followed two approaches: inductive and analytical. We start by presenting the Hadiths that dealt with the topic of prevention in the Sunnah and biography, then we analyze the most prominent methods and applications followed by the Prophet in the prevention of epidemics. The research reached the following results, most of them, the precedence of Sunnah through what was illustrated in the Prophet’s biography in demonstrating the means of devotional and medical prevention against epidemics and their effectiveness in people’s lives. Finally, worshipping by obeying orders and avoiding prohibitions is a reason to prevent the epidemic.
Implementasi Akad Istishna (PSAK Syariah 104) dalam Transaksi Jual Beli Online
Authors: Pekerti Retno Dyah , Faridah Eva , Hikmatyar Missi , Rudiana Irfan Faris
Published: August 2021

Online buying and selling transactions are growing rapidly, from an Islamic perspective, they fall into the jurisprudence muamalah category of business or commerce. In Islam, there are rules governing buying and selling transactions that must be carried out by the seller and the buyer. This research is to explore the pillars and requirements for online buying and selling transactions and the implementation of the Istishna contract which refers to the Islamic PSAK 104 in online transactions. A qualitative method with case study research conducted in Tasikmalaya was chosen as the method in this research. The informants in the research are business people, consumers, academics, and ustadz. The results show that business people generally know about the pillars and requirements for online buying and selling transactions from an Islamic perspective. The Istishna contract has been carried out by business people with the term pre-order, business people do not know and apply the Sharia PSAK 104. The research can be a reference for business people, academics, and input for regulators and the public.
Identification of Zakat Impact Measurement Tools
Authors: Bahri Efri Syamsul , Sulistiawati Sulistiawati
Published: August 2021

Zakat management aims to alleviate poverty and improve the welfare of mustahiq. Various instruments for measuring the impact of zakat on mustahiq are needed to measure the achievement of the goals of zakat management. This study aimed to identify and analyze several instruments to measure the impact of zakat. The analysis was conducted by conducting a literature study on various reference sources. The analysis used a descriptive analysis approach and a content analysis approach. The results of this study found four instruments for measuring the impact of zakat: Social Return on Investment (SROI), Center of Islamic Business and Economic Studies (CIBEST), Sustainable Livelihood Impact Assessment (SLIA), and BAZNAS Index for Sustainable Water and Sanitation (BI- WAS). Overall, all instruments can measure the impact of zakat on mustahiq for zakat disbursements to mustahiq
Peran Lembaga Alternatif Penyelesaian Sengketa Perbankan Indonesia (LAPSPI) dalam Penyelesaian Sengketa Pembiayaan di Bank Syariah
Authors: Ramadhani Tengku Rahmah , Brawijaya Andri , Aziz Imam Abdul
Published: August 2021

The purpose of this study was to determine the Role of the Indonesian Banking Dispute Resolution Alternative Institution (LAPSPI) in Financing Dispute Resolution at Islamic Banks and the dispute settlement process at LAPSPI. The method used is a qualitative descriptive method using content analysis. The data sources used are primary data and secondary data. Based on the results of research related to the role of the Indonesian Banking Dispute Resolution Alternative Institution (LAPSPI), it cannot be used as the main choice in assisting the settlement of problematic financing disputes because it does not have executive power and the decision is a peace agreement. The settlement process at LAPSPI is divided into 3 (three), namely mediation, adjudication and arbitration
Keabsahan Akad Jual Beli Online Muslim Kelas Menengah Kota Yogyakarta Pasca Pandemi Covid-19
Authors: Muzalifah Muzalifah
Published: August 2021

This study aims to determine the validity of the online buying and selling contract after the Covid-19 pandemic. Online buying and selling transactions are increasingly prevalent and have become superior after the Covid-19 pandemic. One of the factors is the government ban on crowds and encouragement to always maintain a safe distance to avoid Covid-19. This study uses a quantitative approach. The data collection technique used a questionnaire distributed to 45 respondents who carried out buying and selling online after the Covid-19 pandemic. Meanwhile, the data analysis used percentages. The results of the study found that only 8.9% of 45 respondents stated that they were buying and selling online to avoid the spread of Covid-19, 22.2% of them stated that online buying and selling was profitable, and 26.7% for easier marketing. While the rest said that buying and selling online was done to save business capital and as a side job. According to Islamic law, there is no prohibition on buying and selling activities after the Covid-19 pandemic as long as it does not conflict with Islamic teachings. The contract in the sale and purchase is valid if it meets the requirements and is in harmony according to Islamic law. The application of khiyar rights in online buying and selling after the Covid-19 pandemic is important to implement. This is done to avoid a loss to one of the parties after the transaction process has taken place.
Hepatitis C Virus and its Relation to Hepatocellular Carcinoma
Authors:   Student, Department of Biotechnology, Uttaranchal College of Science and Technology, Dehradun, Uttarakhand 248001, India., Gururani Mohit , ... Tejpal ,   Junior scientis, DNA Labs - A Centre for Applied sciences , Dehradun, Uttarakhand 248001, India., Sharma Narotam ,   Senior Scientist, DNA Labs - A Centre for Applied sciences , Dehradun, Uttarakhand 248001, India.
Published: July 2021

Hepatocellular carcinoma is the world’s sixth leading cause of death due to its quick progression. It has a poor prognosis and a low survival rate. Though there are several factors leading to malignancy, some of them are not yet fully understood. For example HCV. Hepatitis C virus is known to cause hepatocellular carcinoma and clearing the viral load of HCV from the body using DAAs has helped in improved prognosis and prevention of HCC but there is no concrete evidence to prove the direct carcinogenic effects of HCV in causing HCC. The argument is that HCV does not directly causes HCC but its chronic effects in the liver eventually lead up to HCC.