bluuebunny/crossref_metadata_2025 huggingface dataset:
Endocrine-disrupting substances: I. Relative risks of PFAS in drinking water
Authors: Tomei Torres Francisco Alberto , Masten Susan J.
Published: March 2023

Concentrations of per and polyfluorinated alkyl substances (PFAS) in drinking water are significantly lower than in vivo levels of the native target hormone. These concentrations are orders of magnitude lower than the hormone in question, particularly when corrected for transactivation. A pregnant woman can excrete about 7,000 μg/day of total estrogens. A low-dose oral contraceptive pill contains 20 μg estradiol. Soy-based baby formula contains phytoestrogens equivalent to a low-dose oral contraceptive pill. A woman on a low-dose oral hormone replacement therapy consumes about 0.5–2 mg/day of one or more estrogens. The levels of endocrine-disrupting substances (EDSs) exposure by oral, respiratory, or dermal routes have the potential to make removing PFAS from drinking water due to its estrogenic activity divert valuable resources. These levels become even less of a threat when their estrogenic potencies are compared with those of the target hormones present as contaminants in water and even more so when compared with levels commonly present in human tissues. The fact that PFAS constitute a tiny fraction compared to exposure to phytoestrogens makes the effort even more insignificant. If PFAS are to be removed from drinking water, it is not due to their estrogenic activity.
Cancer Proteomics for Cellular Dysfunction: Insights and Trends
Authors: Rani Anjna , Devi Singh Veena , Mazumder Rupa , Dua Kamal
Published: March 2023

Background:

Cancer is an ailment with having a very low survival rate globally. Poor cancer prognosis
is primarily caused by the fact that people are found to have the disease when it is already well advanced.
The goal of this study is to compile information on new avenues of investigation into biomarkers that may facilitate
the routine detection of cancer. Proteomic analysis has recently developed into a crucial technique for cancer
biology research, working in tandem with genomic analysis. Mass spectrometry techniques are one of several
proteome analysis techniques that allow for the highly precise quantitative and qualitative recognition of hundreds
of proteins in small quantities from various biological materials. These findings might soon serve as the
foundation for better cancer diagnostic techniques.

Methods:

An exhaustive literature survey has been conducted using electronic databases such as Google Scholar,
Science Direct, and PubMed with keywords of proteomics, applications of proteomics, the technology of
proteomics, biomarkers, and patents related to biomarkers.

Result:

Studies reported till 2021 focusing on cancer proteomics and the related patents have been included in
the present review to obtain concrete findings, highlighting the applications of proteomics in cancer.

Conclusion:

The present review aims to present the overview and insights into cancer proteomics, recent breakthroughs
in proteomics techniques, and applications of proteomics with technological advancements, ranging
from searching biomarkers to the characterization of molecular pathways, though the entire process is still in its
infancy.
Obese Mouse Fat Cell-derived Extracellular Vesicles Transport
miR-99a-5p to Mitigate the Proliferation and Migration of Non-small Cell
Lung Cancer Cells
Authors: Zhai Shengping , Li Xiaoping , Lin Tiantian
Published: March 2023

Objective:

Fat cells-derived extracellular vesicles (FC-EVs) play a role in regulating the
tumor microenvironment in cancers by transporting RNAs. MicroRNAs (miRNAs) are vital regulators
of cancer development. This study was conducted to explore the role of FC-EVs in the proliferation
and migration of non-small cell lung cancer (NSCLC) cells, providing targets for NSCLC
treatment.

Methods:

The obese mouse model was established via high‐fat diet (HFD), followed by separation
and characterization of FC-EVs (HFD-EVs). The levels of miR-99a-5p, precursor-miR-99a-5p,
and heparan sulfate-glucosamine 3-sulfotransferase 3B1 (HS3ST3B1) were measured by RT-qPCR
or Western blot assay. Cell proliferation and migration were evaluated by 3-(4, 5-dimethylthiazol-
2-yl)-2, 5-diphenyltetrazolium bromide and wound healing assays. The expression of Cy3-labeled
miR-99a-5p in A549 cells (one NSCLC cell line) was observed via confocal microscopy. The
binding of miR-99a-5p to HS3ST3B1 was analyzed by the dual luciferase assay. Rescue experiments
were performed to confirm the role of HS3ST3B1 in NSCLC cells.

Results:

miR-99a-5p was upregulated in adipose tissues, FCs, and HFD-EVs. HFD-EVs mitigated
the proliferation and migration of NSCLC cells. HFD-EVs transported miR-99a-5p into A549
cells, which upregulated miR-99a-5p expression and inhibited HS3ST3B1 expression in A549
cells. HS3ST3B1 overexpression reversed the inhibition of HFD-EVs on the proliferation and migration
of NSCLC cells.

Conclusion:

HFD-EVs transported miR-99a-5p into NSCLC cells and inhibited HS3ST3B1,
thereby inhibiting proliferation and migration of NSCLC cells.
Pan-cancer Analysis Confirms the Prognostic and Immunological Effects
of Prostate Tumor Overexpressed-1 in Human Cancers
Authors: Liu Fashun , Wan Songlin , Li Yue , Ye Zhenxiong , Li Daojiang , Li Zhen
Published: March 2023

Background:

Prostate tumor overexpressed-1 (PTOV1) is a conserved oncogenic adaptor
protein associated with cancer progression and may be an independent prognostic marker for several
malignancies. Consequently, using pan-cancer research to explore the significance of PTOV1 is valuable,
and may reveal novel targets for cancer treatment.

Methods:

comprehensive bioinformatics analysis of PTOV1 was performed. The qRT-PCR was
utilized to confirm the aberrant PTOV1 expression in several cancer cell lines.

Results:

We observed that PTOV1 mRNA expression was high in 18 cancer tissues and was thereafter
associated with poor survival prognosis in a range of malignancies. The immune subtypes of 14 malignancies
and the molecular subtypes of six malignancies were related to PTOV1. A substantial association
between PTOV1 and immune checkpoint (ICP) genes was also observed. Tumor mutational
burden (TMB), microsatellite instability (MSI), and DNA methylation analyses indicated that PTOV1
acts as a cancer-promoting agent in a series of tumors. In addition, an enrichment study of PTOV1 and
related genes revealed that RNA splicing may be responsible for the involvement of PTOV1 in cancers.
Lastly, we also verified that PTOV1 expression was elevated in bladder cancer, breast cancer,
CESC, LIHC cell lines via qRT-PCR.

Conclusion:

Our bioinformatics research indicated that PTOV1 may be involved in tumor immunity.
Furthermore, differentially expressed PTOV1 was found to be related to poor prognosis in cancers,
and RNA splicing may be the specific mechanism for this effect. Therefore, PTOV1 mRNA and the
corresponding protein may function as potential prognostic indicators and therapeutic targets in various
cancers.
The Effectiveness, Changes in Body Weight, and Menstrual Cycle
Between 2 Rods and 1 Rod Contraceptive Implants after 12 Months of
Insertion
Authors: Santoso Budi , Susanto Lunardhi , Tunjungseto Arif , Widjayanti Yhenti , Fernandus Euvanggelia Dwilda , Devianti  Putri Berliana
Published: March 2023

Background:

Implant as long-acting reversible contraception (LARC) is ideal for Indonesian
women. Two-rod implant (2x75mg levonorgestrel) is the most common implant used in Indonesia.
Another alternative method is a one-rod implant (1x150mg levonorgestrel).

Objective:

This study evaluated the effectiveness, changes in body weight (BW), and menstrual cycle between the one-rod and two-rod implant acceptors.

Methods:

This study was an RCT design with phase II clinical trials; 179 subjects were recruited.
Subjects were met with inclusion and exclusion criteria and divided into one-rod and two-rod groups.
The variables were evaluated within 12 months.

Results:

This study involved 70 subjects in the one-rod implant group and 66 subjects in the two-rod implant
group. At 12 months, there were no differences between the effectiveness of the two types of contraception,
and pregnancy was reported in 1.26% vs 1.31%. The concentration of levonorgestrel in the
one-rod group was 0.31 ng/dL as the median (IQR: 0.33 ng/dL) and 0.34 ng/dL as the median (IQR: 0.33
ng/dL) in the two-rod group (p = 0.438). The BW in the two-rod group increased significantly in month
six (p = 0.035) and twelve (p = 0.017) but not in the one-rod group. Menstrual cycle changes occurred in
51.4% of subjects and 57.6% of subjects in the one- and two-rod groups (p = 0.584), respectively.

Conclusion:

At 12 months, one-rod and two-rod implants had similar effectiveness and concentration of levonorgestrel. Significant weight gain happened in the two-rod group, and the weight gain increased in months six and twelve. Menstrual cycle changes have occurred in both.
Graph Convolutional Neural Network with Multi-Layer Attention Mechanism for Predicting Potential Microbe-Disease Associations
Authors: Wang Lei , Yang Xiaoyu , Kuang Linai , Zhang Zhen , Zeng Bin , Chen Zhiping
Published: March 2023

Background:

Human microbial communities play an important role in some physiological process of human beings. Nevertheless, the identification of microbe-disease associations through biological experiments is costly and time-consuming. Hence, the development of calculation models is meaningful to infer latent associations between microbes and diseases.

Aims:

In this manuscript, we aim to design a computational model based on the Graph Convolutional Neural Network with Multi-layer Attention mechanism, called GCNMA, to infer latent microbe-disease associations.

Objective:

This study aims to propose a novel computational model based on the Graph Convolutional Neural Network with Multi-layer Attention mechanism, called GCNMA, to detect potential microbedisease associations.

Methods:

In GCNMA, the known microbe-disease association network was first integrated with the microbe- microbe similarity network and the disease-disease similarity network into a heterogeneous network first. Subsequently, the graph convolutional neural network was implemented to extract embedding features of each layer for microbes and diseases respectively. Thereafter, these embedding features of each layer were fused together by adopting the multi-layer attention mechanism derived from the graph convolutional neural network, based on which, a bilinear decoder would be further utilized to infer possible associations between microbes and diseases.

Results:

Finally, to evaluate the predictive ability of GCNMA, intensive experiments were done and compared results with eight state-of-the-art methods which demonstrated that under the frameworks of both 2-fold cross-validations and 5-fold cross-validations, GCNMA can achieve satisfactory prediction performance based on different databases including HMDAD and Disbiome simultaneously. Moreover, case studies on three kinds of common diseases such as asthma, type 2 diabetes, and inflammatory bowel disease verified the effectiveness of GCNMA as well.

Conclusion:

GCNMA outperformed 8 state-of-the-art competitive methods based on the benchmarks of both HMDAD and Disbiome.
Exploring the Hepatotoxicity of Drugs through Machine Learning and
Network Toxicological Methods
Authors: Tang Tiantian , Gan Xiaofeng , Zhou Li , Pu Kexue , Wang Hong , Dai Weina , Zhou Bo , Mo Lingyun , Zhang Yonghong
Published: March 2023

Background:

The prediction of the drug-induced liver injury (DILI) of chemicals is still a
key issue of the adverse drug reactions (ADRs) that needs to be solved urgently in drug development.
The development of a novel method with good predictive capability and strong mechanism interpretation
is still a focus topic in exploring the DILI.

Objective:

With the help of systems biology and network analysis techniques, a class of descriptors that
can reflect the influence of drug targets in the pathogenesis of DILI is established. Then a machine
learning model with good predictive capability and strong mechanism interpretation is developed between
these descriptors and the toxicity of DILI.

Methods:

After overlapping the DILI disease module and the drug-target network, we developed novel
descriptors according to the number of drug genes with different network overlapped distance parameters.
The hepatotoxicity of drugs is predicted based on these novel descriptors and the classical molecular
descriptors. Then the DILI mechanism interpretations of drugs are carried out with important network
topological descriptors in the prediction model.

Results:

First, we collected targets of drugs and DILI-related genes and developed 5 NT parameters (S,
Nds=0, Nds=1, Nds=2, and Nds>2) based on their relationship with a DILI disease module. Then hepatotoxicity
predicting models were established between the above NT parameters combined with molecular descriptors
and drugs through the machine learning algorithms. We found that the NT parameters had a
significant contribution in the model (ACCtraining set=0.71, AUCtraining set=0.76; ACCexternal set=0.79,
AUCexternal set=0.83) developed by these descriptors within the applicability domain, especially for Nds=2,
and Nds>2. Then, the DILI mechanism of acetaminophen (APAP) and gefitinib are explored based on
their risk genes related to ds=2. There are 26 DILI risk genes in the regulation of cell death regulated
with two steps by 5 APAP targets, and gefitinib regulated risk gene of CLDN1, EIF2B4, and AMIGO1
with two steps led to DILI which fell in the biological process of response to oxygen-containing compound,
indicating that different drugs possibly induced liver injury through regulating different biological
functions.

Conclusion:

A novel method based on network strategies and machine learning algorithms successfully
explored the DILI of drugs. The NT parameters had shown advantages in illustrating the DILI mechanism
of chemicals according to the relationships between the drug targets and the DILI risk genes in the
human interactome. It can provide a novel candidate of molecular descriptors for the predictions of other
ADRs or even of the predictions of ADME/T activity.
New Approaches for the Synthesis N-alkylated Benzo[b]thiophene Derivatives together
with their Antiproliferative and Molecular Docking Studies
Authors: El-Sharkawy Karam A. , Mohamed Abeer A. , Al Farouk Fatma O. , Mohareb Rafat M.
Published: March 2023

Background:

2-Amino thiophene derivatives are important compounds not only for their uses in many
heterocyclic reactions but also due to their wide range of pharmaceutical and biological activities.

Objective:

The aim of this work was to explore a number of new heterocyclic derivatives, studying their inhibitions
toward cancer cell lines and studying their structure activity relation ship.

Methods:

Alkylation of 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile was achieved through its reaction
with chloroacetone and 2-bromo-1-(4-aryl)ethanone derivatives to give compounds 3 and 11a-c. The produced compoumds
were subjected to further heterocylization reactions and cytotoxic evaluation against the three cancer cell lines
MCF-7, NCI-H460 and SF-268, together with the normal cell line WI 38. Further evaluations were obtained through
studying their inhibitions against cancer cell lines classified according to the disease. Anticancer screening against
hepatocellular carcinoma HepG2 and cervical carcinoma HeLa cell lines for all compounds together with the molecular
docking of 12c, 12d, 12e and 12f were studied.

Results:

Anti-proliferative evaluations and inhibitions for all of the synthesized compounds showed that many compounds
exhibited high inhibitions.

Conclusion:

Toward the three cancer cell lines, compounds 3, 5a, 7a, 9a, 9b, 11b, 12b, 12d, 12e, 12f, 14c, 14e, 14f,
15e, 15f, 16e, 16f, 17c, 18b, 22a and 22c were the most cytotoxic compounds. The high activities of some compounds
were attributed to the presence of the electronegative CN and or Cl groups within the molecule. Most of the tested
compounds exhibited inhibitions higher than the reference doxorubicin toward hepatocellular carcinoma HepG2 and
cervical carcinoma HeLa cell lines. The score of binding energy of compounds 12c, 12d, 12e and 12f was close to the
reference Foretinib which appeared through the molecular docking results of such compounds.
Comparison of Five Escherichia coli Strains to Achieve the
Maximum Yield of a Recombinant Immunotoxin Consisting of an
Antibody against VEGF Conjugated with MAP30 Toxin in a
Benchtop Bioreactor
Authors: Zarei Mina , Morowvat Mohammad Hossein
Published: March 2023

Background:

Cancer is among the leading causes of death worldwide, imposing
high costs on the health systems of all societies. Extensive biological studies are required
to discover appropriate therapies. Escherichia coli has long been regarded as one of the
main biotechnological bio-factories to produce recombinant protein-based therapeutics. In
the present study, five strains of E. coli were compared to achieve the maximum production
of a previously designed recombinant immunotoxin-carrying MAP30 toxin against
VEGF-overexpressed cancer cells in a benchtop bioreactor.

Methods:

The recombinant immunotoxin coding gene sequence was extracted from the
NCBI database. The host used to produce the recombinant immunotoxin were five E. coli
strains of BL21 (DE3), DH5α, SHuffle®T7, XL1-Blue, and Rosetta-gamiTM (DE3). CaCl2
method was used for bacterial transformation. Bacterial growth measurements were performed
using optical density measurements at 600 nm. The immunotoxin production was
measured using SDS-PAGE analysis. The best-producing strain was cultivated in a 10-L
benchtop stirred tank bioreactor. Recent patents on this field were also studied.

Results:

The results demonstrated that the BL21 (DE3) strain had the highest expression of
recombinant protein in comparison to other strains. Moreover, the cell growth of E. coli
BL21 (DE3) and SHuffle®T7 strains before transformation in the LB medium, were significantly
higher in comparison to other strains. Additionally, the transformation of Rosettagami
was associated with decreased cell proliferation. The transformation of the XL1-Blue
strain did not effect cell growth. Analysis of the growth kinetics demonstrated appropriate
proliferation of the transformed BL21 (DE3) cells in the laboratory benchtop bioreactor.

Conclusions:

Based on the results of this study, the BL21 (DE3) strain could be used as a
suitable host for the production of the recombinant immunotoxin against VEGF in stirred
tank bioreactor, which can be employed for the treatment of tumors. Yet, its precise mechanism
must be explored in extensive studies.
Effects of Anti-Sclerostin Antibody Release from Porous Microparticles on
Bone Resorption Inhibition of Osteoblasts
Authors: Watanabe Hajime , Nakagawa Yasuhiro , Ikoma Toshiyuki , Hattori Shinya , Minowa Takashi , Hanagata Nobutaka
Published: March 2023

Background:

Anti-sclerostin antibodies are among the most efficient drugs for the treatment of osteoporosis, and have been also expected for the treatment of local bone disorders. We have previously developed porous microparticles of hydroxyapatite and chondroitin sulfate loading anti-sclerostin antibodies formulated with zinc cations. However, the biological behavior and con-centration dependence of anti-sclerostin antibodies in vitro released from the microparticles remain unclear.

Objective:

Bolus administration and the subsequent release of anti-sclerostin antibodies from the microparticles formulated with or without zinc cations were investigated; bone-resorptive inhibitory effects on mouse MC3T3-E1 osteoblast function were revealed by cell culture using a cell culture insert plate.

Methods:

Differentiation induction culture of osteoblasts was performed after maintaining the concentrations of anti-sclerostin antibodies and sclerostin at previously reported concentrations of 5.0 and 1.0 µg/mL for the first 3 days. Subsequently, the medium was replaced with fresh medium that did not contain anti-sclerostin antibodies but microparticles loading anti-sclerostin antibodies (20 or 80 µg/mg) with or without zinc cations in the cell culture insert. After 11 days of incubation, the bioactivity of the osteoblasts was evaluated using the polymerase chain reaction method.

Results:

The formulation using zinc cations showed an increase of anti-sclerostin antibodies re-leased from the microparticles, which increased the expression of receptor activator of the nuclear factor kappa-B ligand in the osteoblasts on day 14. This result indicates the inhibition of sclerostin-mediated bone resorption. However, the increase of loading amounts of anti-sclerostin antibodies extremely enhanced the subsequent release of anti-sclerostin antibodies, which decreased the inhibition of bone resorption contrary to expectations.

Conclusion:

The moderately sustained release of anti-sclerostin antibodies from the microparticles can promote the inhibition of bone resorption in osteoblasts, supporting the potential of this formulation for the treatment of localized bone disorders.
WITHDRAWN: Neuroprotective Activity of Blepharis maderaspatensis against Colchicine Induced Alzheimer’s Disease Rat Model
Authors: Anawal Lingaraj , V M Chandrashekhar , Shalavadi Mallappa , Teli Shubham
Published: March 2023

Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, therefore, the article has been
withdrawn from the journal The Natural Products Journal.

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham editorial policy on article withdrawal can be found at https://benthamscience.com/pages/editorialpolicies-main

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Application of Face Centered Central Composite Design in Evolution of
Optimized Drug Delivery System of Golden Nutraceutical with Frame
Independent Variables
Authors: Sharma Vijay , Singh Pawan , Singh Lalit , Verma Navneet
Published: March 2023

Background:

Poor solubility of curcumin results in poor rate of absorption, rapid biotransformation
as well as rapid rate of elimination. Due to this curcumin does not show better therapeutic effect
through oral administration, to avoid poor rate of absorption, rapid biotransformation and topical drug delivery
system plays a vital role.

Objective:

The objective of the present work was the successful implementation of face-centered central
composite design (FCCCD) to study various independent variables to develop an optimized formulation.

Methods:

Carbopol 934 P and menthol were considered as independent variables and their impact was determined
on dependent responses like drug content, viscosity, and percent drug release by developing topical
gels using 32 central composite design. Thirteen curcumin loaded topical gels were prepared employing 32
CCD. Characterization of these formulations was done by drug content, viscosity, and percent drug release.

Results:

The effect of independent variable, i.e., the concentration of Carbopol 934P and menthol was determined
over the dependent variables by developing a response surface methodology. Optimized batch was
investigated employing design expert software by overlay plot developed by statistical software with drug
content, viscosity, and percent drug release 99.34%, 82.10 cps, and 65.576% respectively. Optimized data
was evaluated by formulating four validation check batches. Promising results were observed by comparing
the predicted values with experimental values, which proves the validity of the optimized data.

Conclusion:

Therefore, it can be concluded that the application of face-centered central composite design is
a useful statistical tool to get the optimized formulation with the least manpower, material, and money.
Essential Oils as Alternative Antimicrobials: Current Status
Authors: Sahu Ashish , Parai Debaprasad , Choudhary Hari Ram , Singh Desh Deepak
Published: March 2023

It is becoming increasingly difficult to treat bacterial infections with conventional antibiotics as resistance increases with time. Common antibiotics have been irrationally used in the general community, which has resulted in the selection of antibiotic-resistant genes. Despite various modifications that have been done to restore the antimicrobial activities of conventional antibiotics against an array of multi-drug resistant (MDR) strains, it has been unattainable to overcome this hurdle for a long time. Parallelly, the search for a new and alternative drug has become a high priority in every part of the world.

:

In the last two decades, immense interest has grown in natural products as alternative therapeutics due to their lower toxicity, chemical group diversity and biochemical specificity, which are the upper hand compared to antibiotics. Essential oils are naturally found phytochemicals obtained from approximately 60 families of plants. These are composed of 20 to 60 different bioactive components at different concentrations and have already been reported for their antibacterial, antifungal, antiviral, anti-parasitic, insecticidal activities, antioxidant and antiseptic properties. This review focuses on antimicrobial activities, detailed mode of action and the latest progress in the research on the essential oil.
Interesterification Process of Palm Oil Into Biodiesel with Co-solvent Methyl Esters
Authors:   Jurusan Teknik Kimia, Fakultas Teknologi Industri, Institut Teknologi Nasional Malang, Dwi daryono Elvianto
Published: March 2023

One alternative energy that is currently being developed is fatty acid methyl ester (FAME), commonly known as biodiesel. The process of making biodiesel which has so far been carried out is a process of transesterification with alcohol where the byproduct produced is glycerol. Glycerol must be completely separated from biodiesel since it will interfere with engine performance. The method used to produce biodiesel in this study was interesterification. In the interesterification reaction, vegetable oil is reacted with methyl acetate instead of methyl alcohol, which results in triacetin byproduct. Separation of the remaining triacetin from biodiesel is not necessary since it is useful as an additive to biodiesel. To increase the solubility of the reactants, a co-solvent methyl ester is a good choice since it is a reaction product itself. Hence, it does not need a separation process. The operating conditions of the study were reaction temperature 60⁰C, molar ratio of palm oil:methyl acetate = 1:6, reaction time 1 hour, co-solvent mass of 15% oil mass, KOH catalyst mass (0; 0.25; 0.5; 0.75 1% mass of oil) and stirring speed (600,800,1000 rpm). The results demonstrated that the optimum concentration of biodiesel was 4.80%, obtained at a catalyst mass of 0.5% at a stirring speed of 600 rpm. The optimum yield of 5.56% was obtained at a catalyst mass of 0.5% and a stirring speed of 600 rpm. It can be concluded that the optimum condition of the research were: the catalyst mass 0.5%, stirring speed 600 rpm, reaction temperature 60⁰C, reaction time 1 hour, and molar ratio of oil:methyl acetate were 1:6, respectively.
Impact of Social Isolation, Physician-Patient Communication, and Self-perception on the Mental Health of Patients With Cancer and Cancer Survivors: National Survey Analysis (Preprint)
Authors: Choudhury Avishek
Published: March 2023

BACKGROUND

Cancer is perceived as a life-threatening, fear-inducing, and stigmatized disease. Most patients with cancer and cancer survivors commonly experience social isolation, negative self-perception, and psychological distress. The heavy toll that cancer takes on patients continues even after treatment. It is common for many patients with cancer to feel uncertain about their future. Some undergo anxiety, loneliness, and fear of getting cancer again.

OBJECTIVE

This study examined the impact of social isolation, self-perception, and physician-patient communication on the mental health of patients with cancer and cancer survivors. The study also explored the impact of social isolation and physician-patient communication on self-perception.

METHODS

This retrospective study used restricted data from the 2021 Health Information National Trends Survey (HINTS), which collected data from January 11, 2021, to August 20, 2021. We used the partial least squares structural equation modeling (PLS-SEM) method for data analysis. We checked for quadratic effects among all the paths connecting social isolation, poor physician-patient communication, mental health (measured using the 4-item Patient Health Questionnaire [PHQ-4]), and negative self-perception. The model was controlled for confounding factors such as respondents’ annual income, education level, and age. Bias-corrected and accelerated (BCA) bootstrap methods were used to estimate nonparametric CIs. Statistical significance was tested at 95% CI (2-tailed). We also conducted a multigroup analysis in which we created 2 groups. Group A consisted of newly diagnosed patients with cancer who were undergoing cancer treatment during the survey or had received cancer treatment within the last 12 months (receipt of cancer treatment during the COVID-19 pandemic). Group B consisted of respondents who had received cancer treatment between 5 and 10 years previously (receipt of cancer treatment before the COVID-19 pandemic).

RESULTS

The analysis indicated that social isolation had a quadratic effect on mental health, with higher levels of social isolation associated with worse mental health outcomes up to a certain point. Self-perception positively affected mental health, with higher self-perception associated with better mental health outcomes. In addition, physician-patient communication significantly indirectly affected mental health via self-perception.

CONCLUSIONS

The findings of this study provide important insights into the factors that affect the mental health of patients with cancer. Our results suggest that social isolation, negative self-perception, and communication with care providers are significantly related to mental health in patients with cancer.
LARYNGOTRACHEAL TRAUMA MANAGEMENT AND ASSOCIATED MORBIDITY AND MORTALITY: 4-YEAR EXPERIENCE AT A TERTIARY CARE CENTER
Authors: PARMAR SONU , AHUJA PARIDHI , GUPTA RASHMI , GOYAL DIVYA
Published: March 2023

Objective: Cut throat injuries pose a great therapeutic challenge due to the multiple vital structures that are vulnerable to injuries in a small, confined unprotected area. In this study, we describe the site and depth of the injury, etiology, management, and prognosis. Methods: This was a retrospective study of 18 laryngotracheal trauma patients treated at the department of ENT in MDM hospital between April 2017 and January 2020. Results: Out of 176 cases of penetrating neck injury, 18 patients presented with a breach in the laryngotracheal framework. Male: female ratio was 17:1. The peak age of incidence is in the 2nd and 4th decade of life. Accidental cut throat injury was the most common mode of injury (83%), followed by homicidal (11%) and then suicidal (5%). Endotracheal intubation (where possible) or emergency tracheostomy was done to secure the airway in all the cases, followed by surgical debridement and laryngeal/hypopharynx repair. Post-operative endoscopy is useful to identify complications. Wound dehiscence was the most common complication. Conclusion: Cut throat injuries are one of the common ENT surgical emergency. Timely intervention is paramount, because it may otherwise cause death of the patient. Securing the airway, control of hemorrhage, and fluid and blood replacement is the mainstay to prevent complications such as shock, sepsis, laryngeal stenosis, or fistula formation.
COMPARATIVE STUDY ON THE EFFICACY OF TOPICAL METRONIDAZOLE, TOPICAL NITROGLYCERINE, AND TOPICAL DILTIAZEM IN THE MANAGEMENT OF CHRONIC ANAL FISSURE
Authors: GUPTA PURSHOTAM DASS , TAUHEED FAHAD , SARASWAT ANURAG , P Karthik
Published: March 2023

Background and Aims: Chronic anal fissure (CAF) is usually managed with surgical modalities but it imposes huge cost with recurrence rates. Hence, topical therapies are preferred is such cases which has a good patient acceptability rate. The present study aims to compare the topical metronidazole (MTZ), diltiazem (DTZ), and glyceryl trinitrate (GTN) in terms of healing rate and pain reduction in CAF patients. Methods: This was a randomized and prospective study conducted on 90 patients with CAF. The patients were grouped as follows (n=30), Group 1; 1% MTZ gel, Group 2; 0.2% Nitroglycerin ointment, and Group 3 (n=30): 2% DTZ ointment. The patients were evaluated at 2, 4, and 6 weeks for pain using visual analogue score (VAS) and healing rate. The results were compared and p<0.05 was considered as significant. Results: The VAS scores between the groups was found to be non-significant (p>0.05), however the VAS scores where markedly reduced within the group at 6 weeks. The healing rate was higher in MTZ group (90%) as compared to GTN (83.3%) and DTZ group (83.3%) but it was not significant. Regarding side effect, burning sensation was observed in MTZ and GTN, DTZ groups were devoid of side effects. Conclusion: The MTZ was more effective with good healing rate but with few side effects. Regarding the pain reduction, all the groups displayed equivocal effects. Thus topical MTZ is a suitable agent for the faster healing of CAF and thus avoids the requirement of surgical options.
ИССЛЕДОВАНИЕ АЛГОРИТМА ФУНКЦИОНИРОВАНИЯ СИСТЕМЫ ЦЕНТРИРОВАНИЯ КРУГЛОМЕРА
Authors: Епифанцев К.
Published: March 2023

Проведен анализ корреляционных связей в системе компенсации кругломера (корреляционный анализ Спирмена), построены корреляционные графы, отражающие зависимости в программном модуле кругломера значения центрирования, компенсационных коэффициентов от массы пригрузов.
CHIPS ACT И НЕКОТОРЫЕ АСПЕКТЫ СОВЕРШЕНСТВОВАНИЯ ЭКОСИСТЕМЫ НИОКР В США
Authors: Авдонин Б. , Макушин М.
Published: March 2023

В рамках борьбы за сохранение мирового доминирования США уделяют большое внимание стимулированию развития полупроводниковой промышленности (и, прежде всего, микроэлектроники) – как основы развития отраслей радиоэлектронного комплекса и модернизации экономики в целом – на новом технологическом уровне. Важным аспектом этой борьбы является совершенствование экосистемы НИОКР микроэлектроники.
Mercadeo de guajolote (Meleagris gallopavo gallopavo) en Los mercados de Oaxaca.
Authors: Ángel Hernández Arturo , Villegas Aparicio Yuri , Lozano Trejo Salvador , García Munguía Alberto Margarito , GARCIA MUNGUIA CARLOS ALBERTO , García Munguía Otilio
Published: March 2023

La importancia económica, cultural y social del guajolote se evidencia por su amplio uso en la cocina mexicana, celebraciones sociales y religiosas. Los excedentes producidos por la meleagricultura de traspatio son comercializados en los mercados locales, lo que posibilita captar ingresos que permiten complementar la dieta de los productores. El estudio se realizó en el año 2014 en los mercados distritales de la región de los Valles Centrales de Oaxaca, México donde se aplicaron 744 encuestas en un muestreo estratificado de manera dirigida. Posteriormente, con los datos recabados se realizó un análisis estadístico de independencia (X2) (p<0.05). Se obtuvo como resultado que los participantes de la comercialización fueron en su mayoría mujeres (66%) con un rango de edad de 31-59 años, dedicadas a las labores del hogar y del campo. A los productores fue indiferente el sexo y el color de los guajolotes y prefirieron pavipollos para reproducción y a los maduros para consumo en mole. En los mercados se logró observar una mayor comercialización de las hembras (64%), con un peso aproximado 3.1 a 6.1 kg y un precio que oscila entre $231 y 375 por individuo, mientras que los machos pesaron de 5.5 a 7 kg y costaron entre $300 y 450 para machos por animal.
Quantum Contextuality
Authors: Pavicic Mladen
Published: March 2023

Quantum contextual sets have been recognized as resources for universal quantum computation, quantum steering and quantum communication. Therefore, we focus on engineering the sets that support those resources and on determining their structures and properties. Such engineering and subsequent implementation rely on discrimination between statistics of measurement data of quantum states and those of their classical counterparts. The discriminators considered are inequalities defined for hypergraphs whose structure and generation are determined by their basic properties. The generation is inherently random but with the predetermined quantum probabilities of obtainable data. Two kinds of statistics of the data are defined for the hypergraphs and six kinds of inequalities. One kind of statistics, often applied in the literature, turn out to be inappropriate and two kinds of inequalities turn out not to be noncontextuality inequalities. Results are obtained by making use of universal automated algorithms which generate hypergraphs with both odd and even numbers of hyperedges in any odd and even dimensional space – in this paper, from the smallest contextual set with just three hyperedges and three vertices to arbitrarily many contextual sets in up to 8-dimensional spaces. Higher dimensions are computationally demanding although feasible.
Хос хатуу-бөмбөлөг системд интеграл тэгшитгэлийг хэрэглэх нь
Authors: Tsednee Banzragch , Цогбаяр  , Цоохүү
Published: March 2023

Хос хатуу-бөмбөлөг потенциалт системийн хувьд интеграл тэгшитгэлийн онолыг Перкус-Иевикын ойролцоололд хэрэглэв. Системийн эзэлхүүн нягт 0.49 байхад xос бөмбөлгүүдийн диаметрийн харьцааны 0.3, 0.5, 0.6 болон 0.9 утгуудад төлөвийн тэгшитгэлийг бодов. Улмаар компонент тус бүрийн хувьд илүүдэл химийн потенциал болон идэвхийн коэффициентын логарифмыг тооцоолов. Тооцоолсон үр дүнгээ нарийвчлал сайтай Монте-Карло аргаар бодсон үр дүнтэй харьцуулахад сайн тохирч байна.
Agri-food trade resilience among food-deficit countries during the COVID-19 pandemic
Authors: Ahn Soojung , Steinbach Sandro
Published: March 2023

This paper examines the trade resilience of low-income and food-deficit countries (LIFDCs) during the COVID-19 pandemic. Since the pandemic declaration, LIFDCs have faced unique challenges due to their heavy reliance on food imports. This paper identifies the differential trade effects of COVID-19 lockdowns on agri-food exports to LIFDCs using a dynamic treatment effects model and monthly product-level agri-food trade data. The baseline results show a sharp decrease in agri-food exports to LIFDCs in the first three months after the pandemic declaration and a gradual recovery afterward. Additional analyses at the product and country levels show that LIFDCs focused on securing cereal products from foreign sources and that imports of other agri-food products contracted considerably relative to the counterfactual. The foreign supply chains of LIFDCs were less resilient in the first quarter after the treatment than those of other low-income countries, but their recovery was also faster than in those other countries. The paper provides the empirical underpinning for concerns raised by international organizations regarding the resilience of agri-food supply chains and COVID-19 containment measures, revealing the differential impact that lockdowns had on agri-food trade resilience in the developing world.
Corporate governance practices and firm performance: The moderating effect of female directors
Authors: Dike Victor Onuorah , Tuffour Joseph Kwadwo
Published: March 2023

Improved corporate governance practices of banks are viewed as a key mechanism for better performance of banks. Despite the numerous diversification efforts of the Nigerian bank regulators, bank performance remains poor. The study determines the moderating effects of female boards of directors on the relationship between board characteristics and the performance of banks in Nigeria. The quantitative explanatory design utilised a cross-sectional survey sample of 121 respondents from 24 state- and privately-owned banks. Regression analyses were used to examine the effects among the variables. The results showed that board size and board committees (audit, remuneration, and nomination) are positively and significantly related to bank performance. On the contrary, board independence is negatively and significantly related to bank performance. The result revealed that female representation does not have a moderating effect on the relationship between each board size, board independence, and bank performance. Female representation negatively and significantly moderated the relationship between each audit and remuneration committee and bank performance. However, female representation positively and significantly moderated the relationship between nomination committees and bank performance. Our findings shed light on the role of the mandatory policy of including women on banks’ boards and the female board members’ moderating role between the nomination, audit and remuneration committees on one hand and the bank performance on the other
Security Price Analysis using Sentiment Analysis, Polynomial Regression, Markov Chains, and CART Trees
Authors: Mohanty Siddharth
Published: March 2023

Many quantitative funds rely on data collection from buying user trades
from brokerages while other funds attempt to make money off of small
differences in price over minuscule amounts of time. This paper attempts
to architect a python[1] system by which we analyze signals from
Markov Chains[2], Polynomial Regression, and Sentiment Analysis
latter passed into Decision Trees[3] for a holistic evaluation based
solely on publicly available information.
Quantifying Stability in Inverter-based Weak Grids in the Presence of Synchronous Condensers
Authors: Hadavi Sajjad , Mehrizi-Sani Ali , Bahrani Behrooz
Published: March 2023

The high penetration of renewable energy resources integrated via power
electronic inverters in weak and low-inertia grids is introducing new
challenges to power systems. Inverter-based resources (IBRs) do not have
native inertia similar to fossil-fuel-based generators and can cause
sustained oscillations and instability. Synchronous Condensers (SynCons)
are considered as a reborn technology to provide a solution for system
strengthening and inertia supporting in IBR-dominant power systems.
Although SynCons are a well-known technology, additional assessment for
analyzing the stability of a weak grid with a high penetration of
renewable resources in the presence of SynCons is required. This paper
proposes a quantitative index for the stability analysis of a system,
which includes black-boxed IBRs and SynCon. The proposed index is
stemmed from impedance-based stability analysis. In this paper, the
impact of a SynCon on the proposed stability index is evaluated in a
single-machine infinite-bus system, and its accuracy is also verified in
an IEEE 39-bus system. Additionally, the findings are verified using
time-domain simulation tests in PSCAD/EMTDC software.
The German journal on philosophy in Serbia: The first occurrence of the expression "Serbian philosophy"
Authors: Kucinar Zdravko
Published: March 2023

The paper refers to the beginnings of the academic philosophy in Serbia and
to the circumstance that reports about its development. These were the part
of the program of the respectable philosophical Hegelian journal Der
Gedanke, 1861-1863. It refers to the contributions of Dimitrije Matic and
the cooperation of this prominent Serbian philosopher, jurist and politician
with the editor of the journal Karl Ludwig Michelet, who was the first to
use the expression ?Serbian philosophy?. The author reminds us that never
later, when the academic philosophy in Serbia realized remarkable progress,
a foreign publication followed with such attention and according to plan the
philosophical life in Serbia.
Abuse and negligence of children with disabilities in the city of Zrenjanin
Authors: Stepanovic Sasa , Nenadic Violeta
Published: March 2023

The subject of this empirical research is to see the extent to which violence
against children with disabilities is present in our society, in which
families with children with disabilities abuse and/or neglect occurs,
specifically in the city of Zrenjanin. The aim of the research was to
determine whether and to what extent there are certain (and which) forms of
abuse and / or neglect of children and youth with disabilities and which are
the dominant factors for the development and maintenance of this situation,
as well as to determine whether the degree of abuse and / or neglect of
children and youth with disa?bilities in the city of Zrenjanin depends on
certain socio-demographic factors of the family. The task, more precisely,
was to determine the family context in which the abuse and / or neglect of
children with disabilities occurs. Through a questionaire with closed-ended
questions 80 respondents, primary and secondary school students of ?9. May?
in Zrenjanin were interviewed. Students aged 10-21 were selected as the
target group. It was determined that there is a factor that contributes to
the vulnerability and marginalization of this group of children and youth in
relation to children and youth of normal development. The analysis of the
results showed that, out of the total number of respondents, 25% of them
estimated that their living conditions were poor, while (on the total
sample) 16.2% of them answered that (sometimes) they did not have enough
food. Ten percent of them estimated that there are no satisfactory hygienic
conditions (bathroom and hot water). By analyzing the answers to a certain
group of questions, significant data were obtained that support the research
questions that children with disabilities, who come from socially deprived
families with many members and live in suburbs are more exposed to the
possibility of suffering, abuse and / or neglect.