bluuebunny/crossref_metadata_2025 huggingface dataset:
Индикаторы образования: 2022
Authors: Бондаренко Наталья , Гохберг Леонид , Зорина Ольга , Кузнецова Вера , Кузьмичева Любовь , Озерова Ольга , Саутина Елена , Сутырина Татьяна , Шкалева Елена , Шугаль Николай , Бикбаева Алина , Бородина Наталья , Глотко Ольга , Краснова Виктория , Львова Елена , Спорыхина Наталья , Шевцов Евгений , Элефтерова Марина
Published: January 2022

В настоящем сборнике, подготовленном Институтом статистических исследований и экономики знаний Национального исследовательского университета «Высшая школа экономики», представлены данные, отражающие уровень и динамику основных индикаторов образования в Российской Федерации. Сборник содержит сведения об организациях, осуществляющих образовательную деятельность. Отдельные разделы посвящены движению обучающихся в системе образования, участию населения в непрерывном образовании, связи образования с рынком труда, цифровизации образования, финансированию образования, составу обучающихся, персоналу, условиям обучения, образованию лиц с ограниченными возможностями здоровья; представлены международные сопоставления. В публикации использованы данные Федеральной службы государственной статистики, Министерства науки и высшего образования Российской Федерации, Министерства просвещения Российской Федерации, Федерального казначейства, Организации экономического сотрудничества и развития, Международной ассоциации по оценке учебных достижений (IEA), а также собственные методологические и аналитические разработки Института статистических исследований и экономики знаний НИУ ВШЭ. В ряде случаев данные по отдельным показателям уточняют ранее опубликованные.
La nuova morte Una malattia curabile. Riflessioni sul fine vita
Authors: Loner Arnaldo
Published: January 2022

Come un uragano la pandemia da SARS Covid 19 ha investito il pianeta sconvolgendo le consuete abitudini di vita, l’approccio alla malattia e, talora, alla morte di quanti ne sono stati colpiti e dei loro familiari forzatamente allontanati dai propri cari. In questo contesto ancora di più il ruolo del medico, gli aspetti relazionali, e deontologici tra sanitario e paziente sono diventati rilevanti. Da anni l’avvocato Arnaldo Loner, già Presidente dell’Ordine degli Avvocati di Bolzano e del Triveneto e, a suo tempo, accusa nel processo contro il guardiano del lager nazi-fascista della città, si occupa di deontologia medica, di aspetti medico-legali e di problematiche legate al fine vita. Numerose le sue pubblicazioni e le onorificenze ufficiali acquisite anche a livello internazionale. Nel recente convegno regionale dell’ARCA del Trentino Alto Adige svoltosi a Trento l’avvocato Loner ha tenuto una lettura dal titolo: “Riflessioni tra norma e deontologia in sanità”. Il tema della vita e della morte sono stati trattati da ampiamente e con pari dignità sempre tenendo ben presente che “Il tempo di relazione è tempo di cura” ed il medico nell’uno e nell’altro caso è un accompagnatore. Sarà pur vero, come sostiene Erich Fromm, che “gli uomini sono piccole nuvole che si formano e passano senza alterare minimamente le condizioni atmosferiche” ma il loro passaggio sulla terra non può essere ciò che succede mentre noi ci occupiamo d’altro.
Rischio cardio-metabolico e aterotrombosi nella donna in menopausa
Authors: Carcagnì Addolorata , Presbitero Patrizia
Published: January 2022

Le alterazioni ormonali e metaboliche della donna in menopausa sono alla base della comparsa dei principali fattori di rischio cardiovascolari (FRC), della formazione delle placche ateromasiche e di un aumento degli eventi cardiovascolari maggiori ad essa associate. L’insulino-resistenza correlata all’obesità centrale potenzia lo stato infiammatorio e di ipercoagulabilità, già presenti per la variazione del quadro ormonale. Il processo aterosclerotico nei vasi compare nella donna soprattutto dopo la menopausa e si associa ad un aumento di eventi ischemici cardiovascolari, anche acuti dovuti ad aterotrombosi. La formazione della placca nella donna, protetta fino ad allora dagli estrogeni, sembra subire una accelerazione in questa fase, eguagliando in pochi anni gli eventi cardiovascolari degli uomini, e diventando la principale causa di mortalità dopo i 75 anni. Questa rassegna mostra in che modo le alterazioni ormonali e l’insulino-resistenza portano all’insorgenza dei maggiori FRC come il diabete, l’ipertensione e la dislipidemia. Inoltre, evidenzia come l’aumento dello stato infiammatorio in menopausa associato ai FRC determina non solo la formazione della placca ateromasica, ma anche i fenomeni aterotrombotici e gli eventi cardiovascolari maggiori. La comparsa della placca ateromasica e la sua destabilizzazione legata allo stato infiammatorio diventano, quindi, la principale causa di morbilità e mortalità nella donna in menopausa. Pertanto, è importante limitare lo stato infiammatorio controllando l’insorgenza dell’obesità centrale e dell’insulino-resistenza principalmente con la dieta e l’esercizio fisico. Inoltre, è necessario istruire le donne in menopausa a riconoscere i sintomi associati ad eventi cardiovascolari. L’aumento della mortalità, soprattutto per cardiopatia ischemica (CPI) nella donna dipende spesso da un ritardo del trattamento anche per eventi acuti; pertanto, è necessario ricorrere più velocemente al trattamento per migliorare la prognosi.
Impatto del Long COVID sulla medicina di genere
Authors: Chiuini Emilia , Savino Ketty
Published: January 2022

Nei mesi successivi alla diffusione della pandemia da SARS-COV-2 molti pazienti hanno cominciato a riferire persistenza di sintomi dopo la guarigione dalla fase acuta, in prevalenza affaticamento, affanno, disturbi neurologici e psicologici. L’attenzione della comunità scientifica e delle strutture sanitarie si è dovuta quindi rivolgere a questa larga popolazione di individui con prolungamento della sintomatologia per analizzare l’impatto e le conseguenze del fenomeno, denominato “Long COVID”. I risultati delle raccolte dati a livello internazionale hanno mostrato una prevalenza netta del genere femminile in questa popolazione con sintomi persistenti. Il presente articolo passa in rassegna le caratteristiche del Long COVID, analizzando la sua incidenza sulla popolazione generale, la sua probabile eziologia, le differenze di genere e le conseguenze della pandemia in campo non solo sanitario ma anche socio-economico.
Rosuvastatin and atorvastatin in patients with acute coronary syndromes: head-to-head comparison of lipid-lowering and anti-inflammatory effects
Authors: Caravelli Paolo , Orsini Enrico , Pedrinelli Roberto , Bertini Lorenzo , Calogero Enrico , Marzilli Mario
Published: January 2022

Background. Hypercholesterolemia and inflammation both contribute to the pathogenesis of atherosclerosis and its clinical manifestations. Statins, possessing both lipid-lowering and anti-inflammatory properties, are currently recommended in all ischemic syndromes. Purpose. To compare the effects of atorvastatin and rosuvastatin on lipid and inflammatory markers in patients with acute coronary syndromes (ACS). Methods. Two hundred thirty-nine consecutive patients with ACS, without familial hypercholesterolaemia and no statin treatment in the preceding 4 weeks, were randomly assigned within 24 hours after hospital admission to either atorvastatin 80 mg (119 patients) or rosuvastatin 20 mg (120 patients). Lipid and inflammatory markers were assessed before randomization and after 4 and 12 weeks of treatment. Results. Both statins similarly reduced total cholesterol and LDL-cholesterol at 4 weeks, with substantial stability at 12 weeks. At 4 weeks, LDL-cholesterol decreased from 129 mg/dL to 71 mg/dL in atorvastatin group and from 126 mg/dL to 71 mg/dL in rosuvastatin group. Apolipoprotein B significantly decreased in both groups. Otherwise, apolipoprotein A1 increased in rosuvastatin group only. As a consequence, ApoB/ApoA1 ratio decreased more in rosuvastatin group. No significant differences were seen in triglycerides, HDL-cholesterol and Lipoprotein (a) levels. Among inflammatory markers, hs-CRP, interleukin-6, interleukin 1-RA, TGF-β1, and MMP-9 significantly and similarly decreased at 4 and 12 weeks in both groups. Interleukin-10 levels decreased only in patients randomized to atorvastatin. Conclusions. A moderate dose of rosuvastatin provided similar effects, as compared to a high dose of atorvastatin, on a large series of lipid and inflammatory markers. Rosuvastatin was more effective than atorvastatin in reducing ApoB/ApoA1. Considering these findings, rosuvastatin 20 mg daily may be an alternative to atorvastatin 80 mg in acute coronary syndromes.
Tachicardia a complessi stretti con bigeminismo ventricolare e alternanza elettrica
Authors: Carbone Vincenzo , Olivieri Ferdinando , Carbone Giovanni
Published: January 2022

Viene qui discusso un ECG registrato a un maschio di 17 anni giunto in Pronto Soccorso per palpitazioni. Il tracciato mostra una tachicardia sopraventricolare “regolarmente irregolare”, caratterizzata da un costante raggruppamento bigemino dei complessi QRS, che mostrano, altresì, un’alternanza elettrica. Tale presentazione elettrocardiografica rende l’aritmia oltremodo insidiosa, anche perché l’identificazione dell’attività atriale risulta non agevole. Tuttavia, un’analisi accurata dell’ECG consente di giungere alla diagnosi di flutter atriale tipico comune condotto con meccanismo di Wenckebach 3:2.
10X Genomics Single-Nucleus Multiome (RNA + ATAC) Assay for Profiling Adult Human Tissues v1
Authors: Conklin Kimberly , Zhang Bo , Knoten Amanda , Diep Dinh , Lake Blue , Jain Sanjay , Zhang Kun
Published: February 2022

10X Genomics Single Cell 3' (v3) RNA sequencing is a microdroplet-based method that permits the effective capture and sequencing of the mRNA and pre-mRNA molecules from single nuclei [1]. RNA molecules are transcribed and processed within the nucleus before exporting to ER for translation into proteins. As such, nuclear RNA is a mixture of nascent transcripts, partially or fully processed mRNA, and various non-coding RNA molecules. The total RNA content within the nucleus is roughly 10% of the RNA content in a whole cell, but has been found to accurately represent whole cell expression values in adult human tissues [2,3] including the kidney [4]. 10x Genomics Single Cell ATAC sequencing is a microdroplet-based method that allows for the effective capture, sequencing and profiling of accessible chromatin in single nuclei. Chromatin accessibility is a major determinant of gene regulation, defining the transcriptional regulatory networks that determine cellular identity and function as well as additional biological processes (e.g., differentiation, proliferation, development and responses to the extracellular environment). The 10X Multiome ATAC + Gene Expression assay permits capture of both RNA expression and epigenomic profiles from the same nuclei for a deeper understanding of cell type or state gene regulation. Here we present a modified version of the published 10X protocol [5] that we have adapted for the processing of nuclei isolated from adult human organs or tissues (e.g. kidney). Nuclei can be readily isolated from frozen tissues with a combination of chemical and physical treatments that can effectively circumvent the non-uniform or incomplete dissociation of solid tissues into single cells, as well as RNA degradation or artefacts (such as stress response) during dissociation. This 10X Multiome ATAC + Gene Expression protocol permits the generation of a molecular atlas of a human organ or tissue with comprehensive cell types and minimal processing artifacts. References 1. Chromium Single Cell 3' Reagent Kits v3 User Guide (Rev A) CG000183, support.10xgenomics.com. 2. Lake et al. (2016). Science, doi:10.1126/science.aaf1204. 3. Lake et al. (2018). Nature Biotechnology, doi:10.1038/nbt.4038. 4. Lake et al. (2019). Nature Communications, doi:10.1038/s41467-019-10861-2. 5. Chromium Next GEM Single Cell Multiome ATAC + Gene Expression (CG000338 Rev D).
Isolation of Symbiodiniaceae from scleractinian coral hosts suitable for cryopreservation and laser-warming v1
Authors: Bouwmeester Jessica , Daly Jonathan , Quinn Mariko , Mary Hagedorn and
Published: February 2022

This protocol is used to obtain a clean isolate of Symbiodiniaceae extracted from their coral hosts. The freshly isolated symbionts can then be cryopreserved or used for other experiments. This protocol is targeted towards Symbiodiniaceae that we are currently not able to maintain in culture conditions (e.g., most Cladocopium species), but can be used to extract culturable Symbiodiniaceae, as well.
[RETRACTED] Oprah Winfrey CBD Gummies | ⚠️IS IT SAFE TO USE?⚠️ | ITS SCAM OR WORTH THE MONEY | READ THE REAL FACT BEFORE BUY ? v1
Authors: Winfrey CBD Gummies Oprah
Published: January 2022

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Oprah Winfrey CBD Gummies- You plan to recuperate just as truly feel over and above anyone's expectations previously! However when you are encountering steady medical conditions, it tends to be hard to feel your ideal. This is the reason you require theOprah Winfrey CBD Gummies. to assist you with recuperating quickly and regularly with the top promoting hemp oil confine! This uncommon color utilizes 100% regular dynamic fixings just as NO THC to ensure that you get your preeminent recuperating notwithstanding the thing issues are happening in your life to impact your wellbeing.
[RETRACTED] Gro-X Brain Nootropic v1
Authors: not provided groxnootropic
Published: February 2022

[RETRACTED]

It also triggers brain cells that are dead to ensure that the communication between them is quicker and more efficient. This is an excellent product that can aid in enhancing our brain's ability to complete tasks at the same time, and without lagging between.
Health Behavior of People Over 60 and Their Dependence on Socio-Economic Factors
Authors: Kuska Michalina , Nowak Maria Alicja , Żukowska Hanna , Pasek Marcin , Szark-Eckardt Mirosława
Published: January 2022

Health behaviour are human actions which directly or indirectly influence our health. The elderly are a group of people who should especially take care of their health. Taking up this issue is justified by the rising life expectancy of the society and the related increasing costs of social care. Considering the current situation, it seems required to provide the older generation with education in the field of health promotion and health behaviour. The study involved 689 individuals over 60 years of age from Poland. A diagnostic survey was applied in the research. A survey technique was used including the Health Behaviour Inventory (HBI) and own questionnaire. Elderly people have more health behaviour associated with prophylactic measures and a positive mental attitude, but least related to eating habits. Women, people over 75 years of age and better educated people with good financial standing adopt significantly more health behaviour. The subject concerning health behaviour of elderly people needs to be further explored and completed. This study may contribute to better quality of life in elderly population.
How the Responsibility of Digital Support for Older People is Allocated? The Swedish Welfare System at the Crossroads
Authors: Alexopoulou Sofia , Åström Joachim
Published: January 2022

A great welfare challenge today is to promote opportunities of digitalization while limiting social inequalities from digital divides, especially for older people. While the digital divide is a dynamic problem, shifting from physical access to skills and usage, public policies to close the divide do not necessary follow. This study explores who is providing digital support in Sweden by looking at three institutions: (1) the municipal eldercare system, (2) popular education institutions, and (3) the family. The results show that the Swedish policy rely heavily on popular education and family arrangements, leaving many young-old Swedes in need of digital support without public support, while the opposite occurs for very old Swedes who are mostly consumers of welfare technologies. Issues of dependency/independency arise. Given this, the role to the Swedish welfare state needs to be re-evaluated, especially in light of rapid demographic change.
Aging, Marital Status, and Loneliness: Multilevel Analyses of 30 Countries
Authors: Kislev Elyakim
Published: January 2022

Using the European Social Survey and the UN databases, this paper investigates the differences in feelings of loneliness among different marital status groups in old age. Findings presented in this paper suggest that married elders are the least lonely group, while never-married elders come thereafter, better than widowed, divorced, and separated elders. Overall, while married individuals are the happiest and the least lonely of all groups, marriage, on average, ends up with less benign results in late stages of life. The discussion part in this paper suggests that these findings might fit with the “greedy marriage” argument that long-term never-married people develop social skills and circles over time, which allows them to be more immune to loneliness and depression than widowed, divorced, and separated elders.
Азербайджанская анимация в творчестве Фирангиз Гурбановой, её символические приёмы в студии «Бирлик»
Authors:   Институт Архитектуры и Искусства Национальной Академии Наук Азербайджана, Мир-Багирзаде Ф.
Published: January 2022

Азербайджанская анимация начала своё творческое развитие с 1936 года и продолжает её и в наше современное время. Одной из ярких личностей, внёсшей большую и яркую страницу в этом поприще стала Фирангиз Гурбанова. Среди её основных работ с 1988 по 2014 годы считаются: «Сотвори мечту» (1979), «Джинния Маймуна» (1991), «Аквариум» (1983), «Однажды вечером» (1985), «Мама на дереве» (1986), 4 фильма «Композиция на тему…» (1989 – 1992); её сына – Джавида Ахадова «Вкус доброты» (2007), «Добрый ёж» (2009), «Зловредная муха» (2011), «Рисунок в небе» (2012), «Старые часы» (2014). Она в своих анимационных фильмах одна из первой в азербайджанском кино смогла соединить анимацию с игровым кино. В её мультфильмах впервые использовались приёмы подвижной графикой и подсветки изображений цветовыми фильтрами. Фирангиз Гурбанова – заслуженный деятель искусств Азербайджана, является доцентом кафедры рисунка в Азербайджанской Государственной Академии Художеств, член жюри в международных кинофестивалях («Тофузи», 2009), а также руководит киностудией «Бирлик». Её профессиональные фильмы разные по сюжеты, тематике, выполнению композиции и приёмам анимации. Начиная с 2007 года, в своих фильмах, Фирангиз Гурбанова развивает лучшие методы компьютерной графики в этом жанре в своей киностудии «Бирлик», что делает её работы более успешными и интересными.
Использование методов фотограмметрии для создания фотореалистичной модели
Authors:   Университет ИТМО, Смолин А.А. , Малышев К.В. ,   Университет ИТМО, Шевченко Д.В. ,   Университет ИТМО
Published: January 2022

В данной статье рассматривается алгоритм создания фотореалистичных трехмерных моделей для AR-приложений. Помимо представленного пошагового технологического процесса анализируются различные методы оптимизации моделей и демонстрируется то, что данные методы необходимо применять в зависимости от специфики создания конкретного проекта.
Prognostic significance of CD163- and CD68-expressing macrophages in nodular sclerosis Hodgkin lymphoma
Authors: Perfilova E. A. , Minaev M. S. , Diakonov D. A. , Rosin V. A. , Paramonov I. V.
Published: January 2022

The objective of the study was to determine the clinical and morphological criteria and prognostic significance of CD163- and CD68-expressing macrophages in formalin-fixed paraffin-embedded (FFPE) lymph node samples of nodular sclerosis Hodgkin lymphoma.

Materials and methods. We have studied clinical and laboratory characteristics and treatment results of 52 patients with newly diagnosed nodular sclerosis Hodgkin lymphoma. The treatment efficacy was assessed after 2–4 courses of chemotherapy by positron emission tomography combined with computed tomography scan (PET-CT) according to the Deauville scale.

Results. In FFPE lymph node samples, differences in the localization and relative number of CD163-positive macrophages in patients of both study groups were determined. Morphometric counting of CD68-positive cells did not reveal statistically significant intergroup differences. The threshold of CD163-positive cells has been established. The relationship between the CD68 expression level and the response to frontline therapy was not revealed. The ratio of tumorassociated macrophages in each patient was assessed by the CD163/CD68 index. The threshold of the index was determined, which allows predicting the course of nodular sclerosis Hodgkin lymphoma.

Conclusion. The following parameters could be used as additional morphological criteria for predicting the response to frontline therapy in patients with nodular sclerosis Hodgkin lymphoma: tissue distribution pattern and quantitative calculation of macrophage-histiocytic microenvironment subpopulation composition. The results could be used to risk group stratification of patients with nodular sclerosis Hodgkin lymphoma in order to predict the response to initial phase of therapy, as well as to determine personalized treatment approaches.
Immune system changes in the pathogenesis of neurofibromatosis type 1
Authors: Mustafin R. N.
Published: January 2022

Neurofibromatosis type 1 (NF1) is a hereditary tumor syndrome occurring with a frequency of 1: 3000 of the population. NF1 is caused by germline heterozygous mutations in the NF1 gene, which encodes the oncosuppressor neurofibromin. The disease has a specific progressive course with multiple neurofibromas, in the initiation and growth of which NF1+/ – mast cells, macrophages and lymphocytes play an important role. Accordingly, the deficiency of neurofibromin impairs the differentiation and correct functioning of immune system cells. This is evidenced by the increased risk of leukemia in patients with NF1 and the role of NF1 mutations in the development of sporadic hematological malignancies. The development of neurofibromas is associated with the fact that NF1–/ – Schwann cells stimulate the migration of mast cells into the tumor microenvironment, which actively degranulate. The released cytokines promote neoangiogenesis, inflammation, fibroblast proliferation and the production of excess collagen. Therefore, in the treatment of NF1, the use of ketotifen and a kit/ fms kinase inhibitor is recommended. Macrophages and T-lymphocytes in neurofibromas do not provide an antitumor response, but promote inflammation and tumor growth. They produce STAT3 (signal transducer and activator of transcription 3), TGF-β, EGFR, IL-6, IL-4, and PD-1. Therefore, a promising direction is NF1 therapy with STAT3 inhibitors and immune checkpoint inhibitors that block programmed cell death ligand 1 (PD-L1). Activation of MEK signaling pathways in NF1 leads to PD-L1 stimulation; therefore, MEK inhibitors, which also suppress the RAS/RAF/MEK/ERK system, turned out to be effective in the treatment of NF1. For the treatment of sporadic malignant neoplasms, in the development of which NF1 mutations play a role, the developed methods of NF1 therapy can be used.
Rare variants of histiocytic tumors: peculiarities of diagnosis and choice of treatment (literature review)
Authors: Valiev T. T. , Gurieva O. D. , Pavlovskaya A. I.
Published: January 2022

Histiocytic tumors are a highly heterogeneous group of diseases, with Langerhans cell histiocytosis occupying the main place among it. Despite the rare frequency of occurrence, long-term analysis of clinical, morpho-immunological and molecular-biological features has allowed the development of effective treatment protocols (especially in the pediatric cohort of patients). In addition to Langerhans cell histiocytosis, the histiocytic tumors group includes rare and casuistic variants, which include histiocytic sarcoma, Langerhans cell sarcoma, indeterminate dendritic cell tumor, interdigitating dendritic cell sarcoma, follicular dendritic cell sarcoma, and fibroblastic reticular cell tumor. The incidence of certain nosological variants is several cases per hundreds of millions of the population. Not surprisingly, the diagnostic criteria for this group of tumors need to be clarified, as do the therapeutic approaches. This review presents current data on rare histiocytic tumors, clinical features as well as morphological and immunobiological characteristics of the tumor substrate. The results of modern surgical and therapeutic treatment approaches are presented.
Molecular genetic features of cutaneous T-cell lymphomas development on example of mycosis fungoides and Sezary syndrome
Authors: Khadzhieva M. B. , Zakharova E. S. , Kalinina E. V. , Abramov D. S. , Rumyantsev A. G. , Larin S. S.
Published: January 2022

Cutaneous T-cell lymphomas are a heterogeneous group of T-cell lymphoproliferative diseases affecting the skin. Mycosis fungoides and Sezary syndrome are the most studied variants of them. The literature review includes the latest published data on the pathological processes development in mycosis fungoides and Sezary syndrome and the diagnosis of these diseases. The genomic instability features in cutaneous T-cell lymphomas are described, the existing hypotheses of the origin of these diseases are considered based on the results of T-cell receptor repertoire studying.
Laboratory diagnostics stages of myelodysplastic syndrome transformation into acute erythroid leukemia (clinical case report)
Authors: Volgina I. E.
Published: January 2022

This article describes the laboratory diagnostics stages of acute erythroid leukemia clinical case. The following research results allow observing the process of disease formation in development.
Informative value of whole-body magnetic resonance imaging with diffusion-weighted images for the detection of bone marrow infiltration in patients with multiple myeloma (literature review)
Authors: Lutsik N. S. , Mendeleeva L. P. , Yatsik G. A.
Published: January 2022

Magnetic resonance imaging (MRI) is increasingly being used to diagnose bone marrow lesions in patients with multiple myeloma (MM). Since 2014, the results of MRI have been included in the updated criteria of the International Myeloma Working Group. The presence of >1 bone marrow lesion larger than or equal to 5 mm on MRI is considered sufficient for the diagnosis of symptomatic MM, requiring initiation of treatment. MRI assessment of bone marrow is also possible with functional sequences such as diffusion-weighted imaging (DWI), which provide additional information about the bone marrow. This article provides an overview of the possibilities of MRI with anatomical sequences and with DWI for diagnosing, monitoring and evaluating the response to treatment in patients with MM. In patients with monoclonal gammopathy of undetermined significance and smoldering myeloma, in some cases, pathological changes in the bone marrow can be detected by MRI. The presence of >1 bone marrow lesion on MRI is a cut-off value as a prognostic factor for the progression of monoclonal gammopathy of undetermined significance or smoldering myeloma to symptomatic MM. In symptomatic MM, there are four patterns of bone marrow infiltration on MRI – focal, diffuse, “salt-and-pepper” infiltration, and combined diffuse and focal pattern, which have prognostic significance. Patients with diffuse pattern of infiltration on MRI had a 3-year overall survival of 35 % versus 92 % in patients with normal MRI bone marrow. During treatment of MM patients, residual bone marrow lesions are often identified on MRI. MRI residual bone marrow lesions increase the risk of MM relapse. In the group of patients who had residual bone marrow lesions on MRI on the 100th day after autologous hematopoietic stem cell transplant, 2-year progression-free survival was 50 % versus 89 % in patients without bone marrow lesions at the same time. The addition of DWI to the scan protocol helps to differentiate persistent focal bone marrow lesions that can lead to MM relapse after the treatment phase. Apparent diffusion coefficient is a quantitative indicator of DWI. MRI can serve as a valuable tool for assessing the treatment response in patients with MM.
Problem of noise of roof boilers and ways of its solution
Authors: Orlov Oleg G. , Tretyakov Nikolai V.
Published: February 2022

A typical example of the problem of noise impact of the equipment of a roof-top boiler room on the living quarters of apartments on the 18th floor of an apartment building, located under the roof-top boiler room and under the technical floor, is considered. The reasons for the occurrence of the increased noise level have been determined. Violations of the rules for the installation of equipment, affecting the increase in the noise level, the structural features of the building are revealed, ways of eliminating the increased noise level are proposed. The effectiveness of the implementation of the proposed measures to reduce the noise level is assessed.
Conceptual change induced by analogical reasoning sparks "Aha!" moments
Authors:   , Chesebrough Christine B. , Kounios John
Published: February 2022

Although analogical reasoning has been assumed to involve insight and its associated "aha!" experience, the relationship between these phenomena has never been directly probed empirically. In this study we investigated the relationship between representational change and the "aha!" experience during analogical reasoning. A novel set of verbal analogy stimuli were developed for use as an insight task. On each trial, participants were prompted to describe the concept represented by a verbal analogy in A:B::C:D form both before and after the addition of an additional analogical word pair (E:F). On half of the trials, the additional word pair was conceptually close to the first two (consistent trials), whereas on the other half the additional pair was more abstractly related to the first two (expansive trials). We hypothesized that on expansive trials the third pair would force participants to expand their initial representation of the first two pairs to accommodate it, thereby triggering an aha moment. Across two experiments, participants reported significantly stronger aha moments and showed greater evidence of representational change on expansive relative to consistent analogy trials. Further, the strength of reported aha moments was correlated with the degree to which participants' descriptions of the analogies changed over the course of a trial, providing direct evidence towards the theory that aha experiences accompany changes in mental representation. These findings provide empirical support for the hypothesis that analogical reasoning can involve feelings of insight and suggest that measuring subjective aha strength during analogical reasoning may elucidate previously overlooked patterns of representational change during learning and problem solving.
Survei Kondisi Fisik Peserta Kegiatan Ekstrakurikuler Bolabasket
Authors: Valentino Andreano Febrio , Nurrochmah Siti
Published: January 2022

Abstract: The purpose of this study was to determine the ability of the physical condition of the male and female groups participating in basketball extracurricular activities at the Santo Albertus High School, Malang City. The research design used a survey design. The results of the research on the chest pass medicine ball test and the vertical jump test for the male group were in the moderate category, the 20-meter running test, the Illinois test, and the vertical jump test for the female group were in the moderate and poor category. Conclusion from the research results there are still tests that have below good criteria.

Abstrak: Tujuan penelitian ini yaitu untuk mengetahui kemampuan kondisi fisik kelompok putra dan putri peserta kegiatan ekstrakurikuler bolabasket di SMAK Santo Albertus Kota Malang. Rancangan penelitian menggunakan rancangan survei. Hasil penelitian pada tes chest pass bola medicine dan tes vertical jump untuk kelompok putra termasuk dalam kategori cukup, pada jenis tes lari 20 meter, tes illinois, dan tes vertical jump untuk kelompok putri termasuk dalam kategori cukup dan kurang baik. Simpulan dari hasil penelitian masih ada tes yang mempunyai kriteria dibawah baik.
Survei Daya Tahan Kardiovaskular dan Keterampilan Dasar Futsal Peserta Ekstrakurikuler
Authors: Santoso Wahyu Aji , Hariyoko Hariyoko
Published: January 2022

Abstract: The purpose of this study was to determine the level of cardiovascular endurance and basic futsal skills of the MAN 1 extracurricular activities in Kediri. The research design used was survey research with qualitative and quantitative research types. The research subjects were 38 people, the instruments used were multistage fitness test and futsal skills test. The data analysis technique used multistage fitness test norms and futsal skills test norms. From the results of data analysis, 2 conclusions were obtained: (1) the average cardiovascular endurance test (vo2max) was in the moderate category, (2) the basic futsal skills test obtained an average of being in the moderate category.

Abstrak: Tujuan penelitian ini untuk mengetahui tingkat daya tahan kardiovaskular dan keterampilan dasar futsal peserta ekstrakurikuler MAN 1 Kota Kediri. Rancangan penelitian yang digunakan berupa penelitian survei dengan jenis penelitian kualitatif dan kuantitatif. Subjek penelitian sebanyak 38 orang, instrumen yang digunakan berupa multistage fitness test dan tes keterampilan futsal. Teknik analisis data menggunakan norma multistage fitness test dan norma tes keterampilan futsal. Dari hasil analisis data, diperoleh 2 kesimpulan: (1) tes daya tahan kadiovaskular (vo2max ) rata-rata tergolong dalam kategori sedang, (2) tes keterampilan dasar futsal diperoleh rata-rata tergolong dalam kategori cukup.
Pengembangan Model Pembelajaran Kebugaran Jasmani Dengan Modifikasi Permainan Pada Siswa Kelas VIII
Authors: Prayoga Gagah Andika Nanda , Heynoek Febrita Paulina , Yudasmara Dona Sandy
Published: January 2022

Abstract: The purpose of this study is to develop a physical fitness learning model using game modifications for the eighth grade students of SMP Negeri 3 Panarukan which is expected to be used as a means of supporting teachers in providing physical fitness subjects. This research uses the type of research & development (R&D) development with qualitative and quantitative data analysis techniques with percentages. The result of this research is physical fitness learning model using game modification for VIII grade students of SMP Negeri 3 Panarukan.

Abstrak: Tujuan penelitian ini untuk mengembangkan model pembelajaran kebugaran jasmani dengan menggunakan modifikasi permainan pada siswa kelas VIII SMP Negeri 3 Panarukan diharapkan dapat dijadikan sebagai sarana pendukung guru dalam memberikan mata pelajaran kebugaran jasmani. Penelitian menggunakan jenis pengembangan research & development (R&D) dengan teknik analisis data kualitatif dan kuantitatif dengan persentase. Hasil penelitian ini yaitu model pembelajaran kebugaran jasmani dengan menggunakan modifikasi permainan pada siswa kelas VIII SMP Negeri 3 Panarukan.
Pengaruh Metode Pembelajaran Drill Dan Bermain Terhadap Service Bawah Bolavoli Gandu Pada Siswa Sekolah Menengah Pertama
Authors: Agasy Agung Rully Andre , Asim Asim
Published: January 2022

Abstract: The effect of the drill method and the playing method on the ability of service under the volleyball game of Gandu in class VIII students at SMP Kartika IV-9 Malang. The purpose of this study was to describe the difference in the effect of the drill learning method and the playing method on the service ability under level II volleyball game. The type of research used in this study is an experimental method with a Two Group Pretest-Posttest Design. Data analysis used one way analysis technique (one way ANOVA) with a significant level α equal 0.05. The results showed that the Drill method was more influential on the service skills of Gandu volleyball level II for students than the Play method with an average posttest score for the Drill learning method of 6.13 and an average posttest score for the Playing learning method of 5.13.

Abstrak: Pengaruh metode drill dan metode bermain terhadap kemampuan service bawah permainan bolavoli gandu pada siswa kelas VIII di SMP Kartika IV-9 Malang. Tujuan dari penelitian ini adalah mendeskripsikan perbedaan pengaruh metode pembelajaran drill dan metode bermain terhadap kemampuan service bawah permainan bolavoli gandu level II. Jenis penelitian yang digunakan dalam penelitian ini yaitu metode eksperimental dengan rancangan Two Group Pretest-Posttest Design. Analisis data menggunakan teknik analisis variasi satu jalur (one way anova) dengan taraf signifikan α sama dengan 0,05. Hasil penelitian menunjukkan bahwa metode Drill lebih berpengaruh terhadap keterampilan service bawah bolavoli gandu level II pada peserta didik dari pada metode Bermain dengan rata-rata skor posttest metode pembelajaran Drill sebesar 6,13 dan  rata- rata posttest metode pembelajaran Bermain sebesar 5,13.
Hubungan Antara Kekuatan Otot Lengan, Kekuatan Otot Tungkai dan Motivasi Berprestasi Dengan Prestasi Renang Gaya Bebas 50 Meter
Authors: Kurniawan Indra , Winarno Mashuri Eko
Published: January 2022

Abstract: The purpose of this study was to determine the relationship between arm muscle strength, leg muscle strength, and achievement motivation with the 50 meter freestyle swimming achievement. This study uses a correlational design. The subjects of this study were 21 athletes of the Artseidon Swimming Club. Data analysis included: normality test, homogeneity test, linearity test, hypothesis testing using product moment correlation, multiple correlation and multiple regression. The results of data analysis showed that there was a significant relationship between: (1) arm muscle strength and swimming performance, (2) leg muscle strength with swimming performance, (3) achievement motivation and swimming achievement, and (4) arm muscle strength, leg muscle strength. , and achievement motivation with swimming achievement.

 

Abstrak: Tujuan penelitian ini untuk mengetahui hubungan antara kekuatan otot lengan, kekuatan otot tungkai, dan motivasi berprestasi dengan prestasi renang gaya bebas 50 meter. Penelitian ini menggunakan rancangan korelasional. Subjek penelitian ini adalah 21 atlet Klub Artseidon Swimming. Analisis data diantaranya: uji normalitas, uji homogenitas, uji linieritas, uji hipotesis menggunakan korelasi product moment, korelasi berganda dan regresi berganda. Hasil analisis data menunjukkan ada hubungan yang signifikan antara: (1) kekuatan otot lengan dengan prestasi renang, (2) kekuatan otot tungkai dengan prestasi renang, (3) motivasi berprestasi dengan prestasi renang, dan (4) kekuatan otot lengan, kekuatan otot tungkai, dan motivasi berprestasi dengan prestasi renang.
Pengembangan Media Kebugaran Jasmani Unsur Kekuatan Berbasis Multimedia Interaktif
Authors: Mukhlis Novan Arzani , Kurniawan Ari Wibowo , Kurniawan Rama
Published: January 2022

Abstract: Physical Education is an educational process using the learning experience of physical activity, sports, and games. Physical fitness is very important for health, each person's own physical fitness will be different because it is influenced by several factors such as the type of work and lifestyle of each. Strength is a movement or force produced by a muscle or a group of muscles that works optimally and is trained repeatedly. This research and development aims to develop a new teaching material for teachers. At SMP Negeri 4 Malang, PJOK learning still uses books. By using interactive multimedia, it is also hoped that it will make it easier for students to understand the material presented by the teacher.

Abstrak: Pendidikan Jasmani merupakan suatu proses mendidik menggunakan pengalaman belajar aktivitas fisik, olahraga, dan permainan. Kebugaran jasmani itu sangat penting untuk kesehatan, kebugaran jasmani sendiri setiap orang akan berbeda karena dipengaruhi oleh beberapa faktor seperti jenis pekerjaan dan pola hidup masing-masing. Kekuatan merupakan suatu gerakan atau gaya yang dihasilkan oleh otot atau sekumpulan otot yang bekerja maksimal dan dilatih secara berulang-ulang. Penelitian dan Pengembangan ini bertujuan untuk mengembangkan suatu bahan ajar baru untuk guru. Di SMP Negeri 4 Malang dalam pembelajaran PJOK masih menggunakan buku. Dengan menggunakan multimedia interaktif, diharapkan juga agar mempermudah siswa untuk memahami materi yang disampaikan oleh guru.
Survei Keterampilan Gerak Dasar Lokomotor, Nonlokomotor dan Manipulatif pada Siswa Kelas VII Sekolah Menengah Pertama
Authors: Pratama Dony Navia , Nurrochmah Siti
Published: January 2022

Abstract: The results of preliminary observations of the basketball zigzag dribble test, as many as 60% of participants could not do it correctly and accurately. The purpose of this study was to examine the effect of basketball dribble zigzag training using poles and cardboard on improving basketball dribble skills in basketball extracurricular activities at SMA Nasional Malang. The experimental research design, a sample of 40 participants was taken using a purposive proportional systematic random sampling technique from a total of 40 male participants. Fcount 76.22 is more than Ftable α equal to 0.05 4.17. While the results of the advanced test of the LSD technique of dribbling zigzag basketball practice using T count -6.283 and T table 1.685, the results of the advanced test of the LSD technique of dribble zigzag basketball training using cardboard T count 11.364 and T table 1.685, there is an effect of dribble training. zigzag basketball using poles and cardboard to improve basketball dribble skills. A basketball zigzag dribble using a pole is better than a basketball zigzag dribble exercise using cardboard.

 

Abstrak: Hasil observasi awal tes dribble zig-zag bola basket, sebanyak 60% peserta tidak bisa melakukan secara tepat dan akurat. Tujuan penelitian ini adalah untuk mengkajipengaruh latihan dribble zig-zag bola basket menggunakan tiang dan kardus terhadap peningkatan keterampilan dribble bola basket pada peserta kegiatan ekstrakurikuler bola basket SMA Nasional Malang. Rancanagan penelitian eksperimen, sampel 40 peserta diambil menggunakan teknik purposive proporsional systematic random sampling dari jumlah 40 peserta laki-laki. Fhitung 76,22 lebih dari Ftabel α sama dengan 0,05 4,17. Sedangkan hasil uji lanjut teknik LSD latihan dribble zig-zag bola basket menggunakan tiang T hitung -6,283 dan T tabel 1,685, hasil uji lanjut teknik LSD latihan dribble zig-zag bola basket menggunakan kardus T hitung11,364 dan T tabel 1,685, ada pengaruhlatihan dribble zig-zag bola basket menggunakan tiang dan kardus terhadap peningkatan keterampilan dribble bola basket. Latihan dribble zig-zag bola basket menggunakan tiang lebih baik dari pada latihan dribble zig-zag bola basket menggunakan kardus.
Survei Tingkat Keterampilan Teknik Dasar Sepakbola Pemain Akademi Kelompok Usia 17 Tahun
Authors: Putra Nur Samsudin Jaya Ilhami , Hariyanto Eko
Published: January 2022

Abstract: This study aims to determine the level of basic technical skills of football players at the Arema Ngunut Tulungagung Academy. This study used a quantitative descriptive survey method with tests and measurements. Data analysis using percentage descriptive analysis. The results showed that the basic technical skills of football players at the Arema Ngunut Tulungagung Academy U17 were in a moderate category. So it can be concluded that the basic technical skills of football on the Arema Ngunut Tulungagung Academy players have an average ability in the medium category.

Abstrak: Penelitian ini bertujuan untuk mengetahui tingkat keterampilan teknik dasar sepakbola pemain Akademi Arema Ngunut Tulungagung. penelitian ini menggunakan metode survei deskriptif kuantitatif dengan tes dan pengukuran. Analisis data yang menggunakan analisis deskriptif persentase. Hasil penelitian menunjukkan keterampilan teknik dasar sepakbola pemain Akademi Arema Ngunut Tulungagung U17 tahun memiliki kategori sedang. Sehingga dapat disimpulkan bahwa kemampuan teknik dasar sepakbola pada pemain Akademi Arema Ngunut Tulungagung rata-rata memiliki kemampuan pada kategori sedang.
Efektifitas Waktu Pelaksanaan Pembelajaran Pendidikan Jasmani, Olahraga dan Kesehatan di UPT Sekolah Dasar
Authors: Lestari Windah Tri , Winarno Mashuri Eko
Published: January 2022

Abstract: The purpose of this study was to determine the effectiveness of physical education learning time for sports and health at the SD Negeri Sukosewu, Gandusari District, Blitar Regency. This study shows that the effectiveness of the PJOK learning time has not been effective, it can be seen that the average time used is 99 (71%). However, the systematic learning effectiveness was still not effective, the average result of the preliminary activities was 16 (11%), the core activities were 70 (50%) while the closing activities were 13 (9%). According to the criteria for teacher performance appraisal, the time effectiveness in core activities and closing activities is still too little time that has been determined. To overcome this problem, it is necessary to start learning with the right time, use of time and modify the learning model in preliminary activities so that learning is more effective, and improve teacher performance.

Abstrak:Tujuan dari penelitian ini adalah untuk mengetahui efektifitas waktu pembelajaran pendidikan jasmani olahraga dan kesehatan yang bertempat di UPT SD Negeri Sukosewu Kecamatan Gandusari Kabupaten Blitar. Penelitian ini menunjukkan bahwa efektifitas waktu pembelajaran PJOK belum efektif, hal tersebut dapat dilihat dengan rata-rata waktu yang digunakan sebesar 99 (71%) rata-rata tersebut menunjukkan dalam kategori baik sekali. Namun sistematika efektifitas pembelajaran masih belum efektif, hasil rata-rata pada kegiatan pendahuluan dengan total 16 (11%), kegiatan inti sebesar 70 (50%) sedangkan kegiatan penutup sebesar 13 (9%). Menurut kriteria penilaian kinerja guru efektifitas waktu pada kegiatan inti dan kegiatan penutup masih terlalu sedikit waktu yang telah ditentukan. Untuk mengatasi permasalahan tersebut perlu memulai pembelajaran dengan waktu yang tepat, penggunaan waktu dan modifikasi model pembelajaran pada kegiatan pendahuluan agar pembelajaran lebih efektif, serta meningkatkan kinerja guru.