bluuebunny/crossref_metadata_2025 huggingface dataset:
Application of Serious Games in Health Care: Scoping Review and Bibliometric Analysis
Authors: Wang Yue , Wang Zhao , Liu Guoqing , Wang Zhangyi , Wang Qinglong , Yan Yishan , Wang Jing , Zhu Yue , Gao Weijie , Kan Xiangling , Zhang Zhiguo , Jia Lixia , Pang Xiaoli
Published: June 2022

Background

Serious games (SGs) as one kind of intervention that can improve the level of knowledge and change behavior to affect health outcomes has been increasingly applied in health care.

Objective

Analyze hotspots and trends of the application of SGs in health care and provide reference and direction for further research in the future.

Methods

The Web of Science (WoS) Core Collection database was used for extracting the literature on SGs in health care for the period from the database established to 11 October, 2021. Scoping review and bibliometric analysis were used to deeply analyze and visualize countries, categories of studies, annual study output, cited authors, cited journals, cited articles, and keywords of healthcare field.

Results

A total of 1,322 articles were retrieved, then every articles' title and abstract were read one by one, and 795 articles were included after screening with an exponential increase in publication volume. The United States of America made the greatest contribution to global publications regarding SGs in health care. From the total, 20.8% of articles fall under the category of health care sciences services. The target groups were mainly concentrated in children (18.0%), youth (13.8%), the elderly (10.9%), adolescents (9.1%), and adults (3.4%). Baranowski T (n = 103 citations) is the most influential author, followed by Kato PM (n = 73 citations) and Desmet A (n = 58 citations). The top three cited journals were “Plos One” (n = 268 citations), “Games for Health Journal” (n = 209 citations), and “Journal of Medical Internet Research” (n = 197 citations), and the top three cited articles were “A meta-analysis of serious digital games for healthy lifestyle promotion,” “A Systematic Review of Serious Games in Training Health Care Professionals,” and “Video game training enhances cognitive control in older adults.” More and more studies focus on specific age groups, such as children, adolescents, and the elderly. The research hotspots and trends included “rehabilitation,” “medical education,” and “design.”

Conclusions

The application of SGs in health care remains important areas for future research. “Rehabilitation,” “medical education,” and “design” reflected the latest research hotpots and future trends.
Pesticide Residues in Commonly Consumed Vegetables in Henan Province of China in 2020
Authors: Ma Cuicui , Wei Dandan , Liu Pengling , Fan Keliang , Nie Luting , Song Yu , Wang Mian , Wang Lulu , Xu Qingqing , Wang Juan , Shi Jiayu , Geng Jintian , Zhao Mengzhen , Jia Zexin , Huan Changsheng , Huo Wenqian , Wang Chongjian , Mao Zhenxing , Huang Shan , Zeng Xin
Published: June 2022

Background

Pesticides are widely used in agricultural production to control insect pests and regulate plant growth in China, which may result in the presence of some pesticide residues in the vegetables. However, few studies of monitoring pesticides have been conducted in Henan Province. The aim of this study was to evaluate the level of pesticide residues in commonly consumed vegetables in the regions of Henan Province.

Methods

In this study, we collected 5,576 samples of 15 different vegetables in 17 areas from Henan Province during 2020. Eight kinds of pesticides were analyzed by gas chromatography-mass spectrometry (GC-MS), including procymidone, lambda-cyhalothrin, cypermethrin, pendimethalin, isocarbophos, isazophos, fenthion and deltamethrin. The chi-square test was used to compare the detection rates of pesticide residues in different regions.

Results

Of all the pesticides above, procymidone, lambda-cyhalothrin, cypermethrin, pendimethalin and isocarbophos were detected in vegetables, the detection rates were 27.0%, 16.2%, 11.4%, 3.5%, and 1.9%, respectively. However, isazophos, fenthion, and deltamethrin were not detected. In addition, procymidone, lambda-cyhalothrin, and cypermethrin were detected in urban areas, while pendimethalin was detected in rural areas. The detection rates of cypermethrin and pendimethalin in rural were 19.8% and 5.4%, respectively, which in urban were at relatively lower levels (13.7% and 1.9%, respectively) (P < 0.05). Compared the differences of pesticide detection rates among five areas of Henan province, we found that there were statistical differences in the detection rates of procymidone, cypermethrin and lambda-cyhalothrin in different regions (all P < 0.05).

Conclusion

The results have revealed that the pesticide residues are present. Higher detection rates and more types of pesticides were found in rural areas than urban areas. In addition, there were higher detection rates in Eastern Henan. The findings provided valuable information on the current pesticide residues status, which can be a reference of pesticide supervision and management.
The Effect of Flywheel Inertia on Peak Power and Its Inter-session Reliability During Two Unilateral Hamstring Exercises: Leg Curl and Hip Extension
Authors: de Keijzer Kevin L. , McErlain-Naylor Stuart A. , Beato Marco
Published: June 2022

This study investigated the effect of flywheel moment of inertia (0.029, 0.061, and 0.089 kg·m2) on concentric and eccentric peak power and eccentric:concentric peak power ratio during unilateral flywheel leg curl and hip extension exercises. Moreover, the inter-session reliability of peak power was analyzed during both exercises. Twenty amateur male soccer athletes attended five visits—performing three sets of eight repetitions of either unilateral leg curl or hip extension (all three moments of inertias) during each visit. For the unilateral leg curl, there were no differences in any measure between moments of inertia (p = 0.479) but a higher eccentric than concentric peak power for all moments of inertia (p < 0.001). For the unilateral hip extension, differences between moments of inertia were reported for all measures (p < 0.05). Specifically, the lowest moment of inertia elicited the greatest concentric peak power (p = 0.022), there were no differences with the medium inertia (p = 0.391), and the greatest moment of inertia obtained the greatest eccentric peak power (p = 0.036). Peak power measures obtained acceptable to excellent reliability while the eccentric:concentric ratio reported unacceptable to good reliability for both exercises. A variety of moments of inertia can elicit high eccentric knee flexor demands during unilateral leg curls, whereas higher moments of inertia are needed to achieve an eccentric-overload in peak power during hip extensions. Different exercises may have different inertia-power relationships. Concentric and eccentric peak power measures should continue to inform training, while the eccentric:concentric ratio should not be used.
Treatment With Cytarabine at Initiation of Therapy With Cyclosporine and Glucocorticoids for Dogs With Meningoencephalomyelitis of Unknown Origin Is Not Associated With Improved Outcomes
Authors: Barber Renee , Downey Koos Lauren
Published: June 2022

Meningoencephalomyelitis of unknown origin (MUO) is a common disorder of dogs that results in significant morbidity and mortality. The ideal treatment regimen is not known but a second immunosuppressive agent is often utilized in combination with glucocorticoids to increase efficacy and reduce side effects. Recently, a benefit to using a cytosine arabinoside (CA) constant rate infusion (CRI) at the time of diagnosis has been demonstrated. Here, a retrospective study was performed to determine if administration of CA at the time of diagnosis would alter prognosis in dogs receiving cyclosporine and prednisone for treatment of MUO. Medical records of 51 client-owned dogs diagnosed with MUO at one institution were reviewed (2009-2019). All dogs were treated with cyclosporine and a tapering course of prednisone. Twenty-one dogs received a single initial 200 mg/m2 treatment with CA either as a CRI or subcutaneously. Significantly more patients in the CA treatment group were obtunded on presentation but all other baseline parameters were similar between groups. No differences in success (defined as sustained improvement on neurological exam with owner perceived good quality of life), relapse, or death were identified at 1-, 3-, 6-, 9-, 12-, 18-, or 36-month time points. These results do not support treatment with CA (either as a CRI or subcutaneously) at the time of diagnosis in dogs treated with cyclosporine and prednisone.
Constraint Preserving Mixers for the Quantum Approximate Optimization Algorithm
Authors: Fuchs Franz Georg , Lye Kjetil Olsen , Møll Nilsen Halvor , Stasik Alexander Johannes , Sartor Giorgio
Published: June 2022

The quantum approximate optimization algorithm/quantum alternating operator ansatz (QAOA) is a heuristic to find approximate solutions of combinatorial optimization problems. Most of the literature is limited to quadratic problems without constraints. However, many practically relevant optimization problems do have (hard) constraints that need to be fulfilled. In this article, we present a framework for constructing mixing operators that restrict the evolution to a subspace of the full Hilbert space given by these constraints. We generalize the “XY”-mixer designed to preserve the subspace of “one-hot” states to the general case of subspaces given by a number of computational basis states. We expose the underlying mathematical structure which reveals more of how mixers work and how one can minimize their cost in terms of the number of CX gates, particularly when Trotterization is taken into account. Our analysis also leads to valid Trotterizations for an “XY”-mixer with fewer CX gates than is known to date. In view of practical implementations, we also describe algorithms for efficient decomposition into basis gates. Several examples of more general cases are presented and analyzed.
A Review on Thomson Coil Actuators in Fast Mechanical Switching
Authors: Al-Dweikat Mohmmad , Cui Jian , Sun Shuai , Yang Mingming , Zhang Guogang , Geng Yingsan
Published: June 2022

With the rapid development of DC power systems and the increasing demand for DC circuit breakers, electromagnetic repulsive drives-based Thomson coil actuators (TCA) are widely investigated to provide the high-speed actuating required for ultra-fast mechanical switches, especially those used in hybrid DC circuit breakers. The actuating mechanism is required to be fast, reliable, and economic. This article summarizes the development of Thomson coil actuators in circuit breakers in recent years, further illustrating the basic principles and the actuator topology. In addition, it discusses the various structural components of TCA and describes the utilized modeling and simulation methods. The main objective was to provide a comprehensive overview of the TCA field.
Analyzing Rice Grain Collision Behavior and Monitoring Mathematical Model Development for Grain Loss Sensors
Authors: Li Depeng , Wang Zhiming , Liang Zhenwei , Zhu Fangyu , Xu Tingbo , Cui Xinyang , Zhao Peigen
Published: June 2022

Grain loss in the harvesting process of combine harvesters not only causes economic losses to farmers but also affects the soil environment because of the lost grain covering the soil, influencing crop growth in the next season. Grain sieve loss-monitoring sensors represent an important accessory in combine harvesters, as they can not only provide current grain loss levels for the operator to adopt a rational action in time but also serve as an important performance signal for the control system. To reflect the rice grain sieve loss level of combine harvesters in real time, an indirect grain sieve loss-monitoring system is proposed in this paper. First, the grain collision rise time was obtained by the finite element method (FEM), and the parameters of the grain loss sensor signal processing circuit were determined accordingly to upgrade the monitoring accuracy. Then, grain loss distribution behind the cleaning shoe was analyzed in detail under different working parameters. Grain loss distribution functions at the end of the sieve and a monitoring mathematical model with relevant variables were established based on the laboratory experiment results. Finally, calibration experiments were carried out to verify the measurement accuracy of the sensor on a cleaning test bench, with an obtained relative monitoring error ≤6.41 % under different working conditions.
The Method of Calculating Ploughshares Durability in Agricultural Machines Verified on Plasma-Hardened Parts
Authors: Gulyarenko Alexandr , Bembenek Michał
Published: June 2022

Reliability consists of four components: failure-less operation, maintainability, durability, and preservation ability. For different machines and different conditions of operation, different combinations of these properties, and differences in how they are balanced and proportioned are essential. For tractors, the most important aspect of reliability is maintainability, while for agricultural machines, durability is most important. Using the example of a ploughshare, the issue of increasing the durability has been studied; a method for calculating the durability of a ploughshare for various types of soils has been described. The use of plasma hardening of the surface of a 65G-steel ploughshare has been proposed; the effectiveness of plasma hardening of soil-cutting parts and its economic feasibility have been proved. Due to hardening to a depth of 1–1.8 mm, the service life of parts increases by 2–3 times; moreover the downtime of expensive machine-tractor units for replacing worn-out parts is reduced.
Growth, Leaf Morphological and Physiological Adaptability of Leaf Beet (Beta vulgaris var. cicla) to Salt Stress: A Soil Culture Experiment
Authors: He Hua , Zhou Weiwei , Lü Haofeng , Liang Bin
Published: June 2022

Soil salinization is a worldwide problem affecting agriculture and the environment. Utilizing saline land by screening and cultivating salt-tolerant crops is an economical and ecological solution. Leaf beet (Beta vulgaris var. cicla) is an important vegetable resource and has certain salt tolerance, but what concentration it can tolerate still remains to be verified. Hence, this work explored the adaptability of leaf beet to salt stress. A soil culture experiment was conducted. By adding NaCl to the soil, the concentrations of 0% (S0), 0.3% (S3), 0.5% (S5) and 0.7% (S7) NaCl salinity were set to analyze the changes of leaf beet growth (plant height, leaf number and biomass); leaf morphology (leaf area, shape, leaf mass per area (LMA) and tissue density); and leaf physiology (chlorophyll content, leaf relative water content (LRWC), water content at saturation (WCS), water saturation deficit (WSD) and succulence). The results showed that 0.3% NaCl salinity increased LMA and decreased biomass, while the rest were almost the same as the control (S0). Under 0.5% and 0.7% NaCl salinity, LRWC decreased significantly, while WCS and WSD increased significantly. Under such salt stress, the leaf beet adapted by reducing plant height, delaying the engendering of new leaves, decreasing leaf area, changing leaf shape, maintaining high chlorophyll content, and increasing LMA, tissue density and succulence. With these strategies, the leaf beets survived under salt stress up to 0.7% NaCl salinity with a certain biomass, providing a meaningful exploration for the multi-purpose planting and application of leaf beets on saline soils.
Humate Combined with Film-Mulched Ridge-Furrow Tillage Improved Carbon Sequestration in Arid Fluvo-Aquic Soil
Authors: Yang Fengke , He Baolin , Zhang Guoping
Published: June 2022

Commercial humic fertilizers (humates) can be used to improve carbon sequestration. In this study, a 3-year field trial (2016–2018) employed four treatments to investigate the mechanism by which humate increases carbon sequestration in fluvo-aquic soils: (1) blank: bare soil with no agricultural treatment; (2) control: standard film mulch (FM) ridge-furrow tillage (which acts as CK); (3) humate: FM tillage plus humate; and (4) straw: FM tillage plus straw. The three treatments strongly affected the soil carbon sequestration, with the humate and straw treatments more significant than the blank treatment. Moreover, the ≥2.0-mm macroaggregate fraction, >1-mm soil aggregate-associated carbon, weight mean diameter (MWD) and geometric mean diameter (GMD), and microbial biomass nitrogen (MBN) values for the straw and humate treatments were all significantly increased (p < 0.05), increasing the carbon sequestration by 1.9 and 0.9 Mg C ha−1y−1 compared to the control, respectively. Carbon sequestration was significantly associated with >1.0-mm aggregate-associated C, MWD, GMD, MBN, and organic C input. Humate and straw synergistically regulate the soil and microbial processes and greatly increase the straw C return to soil while efficiently increasing the macroaggregate fraction and stability, macroaggregate-associated carbon, and physical protection of aggregates, thereby increasing the carbon sequestration. Therefore, humate may be a novel economical alternative to straw to efficiently increase the carbon sequestration in dry fluvo-aquic soils.
Numerical Simulation of Airborne Disease Spread in Cage-Free Hen Housing with Multiple Ventilation Options
Authors: Chen Long , Fabian-Wheeler Eileen E. , Cimbala John M. , Hofstetter Daniel , Patterson Paul
Published: June 2022

The current ventilation designs of poultry barns have been present deficiencies with respect to the capacity to protect against disease exposure, especially during epidemic events. An evolution of ventilation options is needed in the egg industry to keep pace with the advancing transition to cage-free production. In this study, we analyzed the performances of four ventilation schemes for constraining airborne disease spread in a commercial cage-free hen house using computational fluid dynamics (CFD) modeling. In total, four three-dimensional models were developed to compare a standard ventilation configuration (top-wall inlet sidewall exhaust, TISE) with three alternative designs, all with mid-wall inlet and a central vertical exhaust. A one-eighth scale commercial floor-raised hen house with 2365 hens served as the model. Each ventilation configuration simulated airflow and surrogate airborne virus particle spread, assuming the initial virus was introduced from upwind inlets. Simulation outputs predicted the MICE and MIAE models maintained a reduced average bird level at 47% and 24%, respectively, of the standard TISE model, although the MIRE model predicted comparable virus mass fraction levels with TISE. These numerical differences unveiled the critical role of centrally located vertical exhaust in removing contaminated, virus-laden air from the birds housing environment. Moreover, the auxiliary attic space in the MIAE model was beneficial for keeping virus particles above the bird-occupied floor area.
An Extract of Artemisia argyi Leaves Rich in Organic Acids and Flavonoids Promotes Growth in BALB/c Mice by Regulating Intestinal Flora
Authors: Ma Qianbo , Tan Dejin , Gong Xiaoxiao , Ji Huiming , Wang Kexin , Lei Qian , Zhao Guoqi
Published: June 2022

In the context of global restrictions on the use of antibiotics, there has been increased research on natural plant-based ingredients as additives. It has been proved that many natural active ingredients contained in plants have positive effects on animal growth regulation. Artemisia argyi (A. argyi) is a traditional Chinese herbal medicine, and its extracts have been reported to have a variety of biological activities. Therefore, in order to explore the potential of the active extract of Artemisia argyi leaves (ALE) as a plant source additive, mice were fed with ALE at different concentrations for 60 days. Finally, the effects of ALE were evaluated by the growth indexes, blood indexes, and intestinal microflora changes of the mice. It was found that a medium concentration of ALE (150 mg/kg) could promote growth, and especially improved the feed efficiency of the mice. However, high concentrations of ALE (300 mg/kg) had some negative effects on the growth of mice, especially liver damage, which significantly increased AST and ALT levels in the blood. Therefore, the 150 mg/kg ALE treatment group was selected for 16S rDNA analysis. It was found that ALE could play a positive role by regulating the proportion of Bacteroidetes and Firmicutes in the intestinal tract. In particular, it can significantly up-regulate the quantities of Akkermansia and Bifidobacterium. These results suggest that ALE at appropriate concentrations can positively regulate animal growth.
Quality Assessment of Day-Old Chickens on the Broiler Farms of Hong Kong
Authors: Nekouei Omid , Yau Denis , MacKinnon Brett , Magouras Ioannis , Conan Anne , Elsohaby Ibrahim , Paudel Surya , Pfeiffer Dirk U.
Published: June 2022

The present study aimed to investigate the quality of newly hatched broiler chicks delivered to Hong Kong (imported or local), and to develop tailored recommendations to improve their management. During 2019–2021, 70 batches (34 imported from mainland China and 36 local) of one/three day old chicks on 11 broiler farms were studied. From each batch, 23 or 24 chicks (1647 in total) were assessed for abnormalities in appearance, navel, crop filling, dehydration, body weight, and length uniformity. Chicks were sacrificed, and yolk sac residues in three day old chicks were measured. Maternally derived antibody levels against Newcastle disease virus (NDV), infectious bursal disease virus (IBDV), and avian reovirus (ARV) were measured in all chicks using an enzyme-linked immunosorbent assay (ELISA). The proportion of abnormal navel in most batches is high (median: 59%), ranging between 0 and 100%. The average length of chicks within batches ranges between 16.3 and 20.7 cm, and their average weights are 31–38.5 g upon delivery to the farms. On average, imported batches have a higher body weight and length than their local counterparts. The average yolk-free weight varies between 45 and 55 g, which is significantly lower in local batches (33–43 g). The mean antibody titers against NDV and ARV are higher in imported batches than in the local ones. In contrast, the mean antibody titer against IBDV is significantly lower in the imported batches. Concerning the overall lower quality of local chicks compared to the imported batches, establishing a well-managed broiler breeder farm and a hatchery in Hong Kong is highly recommended to enhance the health and productivity of the local broiler chicken industry.
Non-Volatile and Volatile Bioactives of Salvia officinalis L., Thymus serpyllum L. and Laurus nobilis L. Extracts with Potential Use in the Development of Functional Beverages
Authors: Maleš Ivanka , Dragović-Uzelac Verica , Jerković Igor , Zorić Zoran , Pedisić Sandra , Repajić Maja , Garofulić Ivona Elez , Dobrinčić Ana
Published: June 2022

Functional beverages based on herbal extracts are highly demanded products due to the presence of bioactives with promising health benefits and interesting and characteristic sensory properties. Mediterranean medicinal and aromatic herbs contain a wide range of bioactives (non-volatile polyphenols, volatile terpenes) that are important constituents of herbal extracts and essential oils. The antioxidant capacity and potential health benefits of these bioactives could be associated with their synergistic effects. Therefore, this study aimed to characterize the non-volatile and volatile bioactives of sage (Salvia officinalis L.), wild thyme (Thymus serpyllum L.) and laurel (Laurus nobilis L.) aqueous extracts and their two- and three-component mixtures as well as their antioxidant capacity. The content of total phenols, flavonoids, hydroxycinnamic acids and flavonols was determined spectrophotometrically. Individual polyphenols were analyzed by LC-MS/MS, the volatiles were analyzed by HS-SPME/GC-MS, and the antioxidant capacity was analyzed by ORAC and DPPH assays. The results showed that aqueous extracts of all examined herbs and their mixtures contained a high content of phenolic compounds ranging from 0.97 to 2.79 g L−1 of the sample, among which the most common were flavonols. At the same time, mono- and sesquiterpenes were the main volatiles. All extracts showed high antioxidant capacity, especially L. nobilis (781.62 ± 5.19 μmol TE mL−1 of the sample in the DPPH assay; 1896.10 ± 8.77 μmol TE mL−1 of the sample in the ORAC assay) and the two-component mixture of L. nobilis and T. serpyllum (679.12 ± 5.19 μmol TE mL−1 in the DPPH assay; 1913.38 ± 8.77 μmol TE mL−1 in the ORAC assay). Mixtures of herbal extracts have been shown to possess additive or synergistic effects, consequently contributing to higher antioxidant capacity. Therefore, two-component mixtures of herbal extracts showed promising potential for the production of functional beverages.
Adipocyte-Specific Expression of PGC1α Promotes Adipocyte Browning and Alleviates Obesity-Induced Metabolic Dysfunction in an HO-1-Dependent Fashion
Authors: Shen Shin-Hsueh , Singh Shailendra P. , Raffaele Marco , Waldman Maayan , Hochhauser Edith , Ospino Juancarlos , Arad Michael , Peterson Stephen J.
Published: June 2022

Recent studies suggest that PGC1-α plays a crucial role in mitochondrial and vascular function, yet the physiological significance of PGC1α and HO expression in adipose tissues in the context of obesity-linked vascular dysfunction remains unclear. We studied three groups of six-week-old C57BL/6J male mice: (1) mice fed a normal chow diet; (2) mice fed a high-fat diet (H.F.D.) for 28 weeks, and (3) mice fed a high-fat diet (H.F.D.) for 28 weeks, treated with adipose-specific overexpression of PGC-1α (transgenic-adipocyte-PGC-1α) at week 20, and continued on H.F.D. for weeks 20–28. R.N.A. arrays examined 88 genes involved in adipocyte proliferation and maturation. Blood pressure, tissue fibrosis, fasting glucose, and oxygen consumption were measured, as well as liver steatosis, and the expression levels of metabolic and mitochondrial markers. Obese mice exhibited a marked reduction of PGC1α and developed adipocyte hypertrophy, fibrosis, hepatic steatosis, and decreased mitochondrial respiration. Mice with adipose-specific overexpression of PGC1-α exhibited improvement in HO-1, mitochondrial biogenesis and respiration, with a decrease in fasting glucose, reduced blood pressure and fibrosis, and increased oxygen consumption. PGC-1α led to the upregulated expression of processes associated with the browning of fat tissue, including UCP1, FGF21, and pAMPK signaling, with a reduction in inflammatory adipokines, NOV/CCN3 expression, and TGFβ. These changes required HO-1 expression. The R.N.A. array analysis identified subgroups of genes positively correlated with contributions to the browning of adipose tissue, all dependent on HO-1. Our observations reveal a positive impact of adipose-PGC1-α on distal organ systems, with beneficial effects on HO-1 levels, reversing obesity-linked cardiometabolic disturbances.
3β-Hydroxy-5β-hydroxy-B-norcholestane-6β-carboxaldehyde (SEC-B) Induces Proinflammatory Activation of Human Endothelial Cells Associated with Nitric Oxide Production and Endothelial Nitric Oxide Synthase/Caveolin-1 Dysregulation
Authors: Nasoni Maria Gemma , Benedetti Serena , Crinelli Rita , Palma Francesco , Canonico Barbara , Monittola Francesca , Zerbinati Chiara , Iuliano Luigi , Luchetti Francesca
Published: June 2022

Oxysterols are a family of 27-carbon cholesterol oxidation derivatives found in low-density lipoproteins (LDLs) and atherosclerotic plaques where they trigger several biological responses involved in the initiation and progression of atherosclerosis. Several pieces of evidence suggest that oxysterols contribute to endothelial dysfunction (ED) due to their ability to alter membrane fluidity and cell permeability leading to inflammation, oxidative stress and apoptosis. The present study aimed to investigate the molecular events occurring in human microvascular endothelial cells (HMEC-1) in response to autoxidation-generated 3β-hydroxy-5β-hydroxy-B-norcholestane-6β-carboxaldehyde (SEC-B) exposure. Our results highlight that SEC-B rapidly activates HMEC-1 by inducing oxidative stress, nitric oxide (NO) production and pro-inflammatory cytokine release. Exposure to SEC-B up to 24 h results in persistent accumulation of the vasodilator NO paralleled by an upregulation of the endothelial nitric oxide synthase (eNOS) enzyme and downregulation of Caveolin-1 (Cav-1) protein levels. Moreover, reduced expression and extracellular release of the vasoconstrictor factor endothelin-1 (ET-1) are observed. Furthermore, SEC-B stimulates the expression of the cytokines interleukin-6 (IL-6) and tumor necrosis factor-like weak inducer of apoptosis (TWEAK). This proinflammatory state leads to increased monocyte recruitment on activated HMEC-1 cells. Our findings add new knowledge on the role of SEC-B in ED and further support its potential implication in atherosclerosis.
Study on the Bending Stiffness of Joints Connecting Porcelain Bushings and Flanges in Ultra-High Voltage Electrical Equipment
Authors: Zhu Quanjun , Zhang Xingui , Gao Zhengguo
Published: June 2022

In this study, the equivalent bending stiffness of cement-bonded joints connecting the porcelain bushing and flange in ultra-high voltage (UHV) electrical equipment was investigated. A mechanical bending model of the joint was developed based on its structural features, and a new equation for the equivalent bending stiffness of the joint was proposed. Based on experimental data for nine UHV porcelain bushings, a dimensionless elasticity coefficient for the equivalent bending stiffness equation was determined. Finally, considering two 1000 kV arresters as examples, the bending stiffness was calculated using the equation proposed in this paper and that which is used in China’s seismic code. A comparison of the results shows that the equation proposed in this study is in better agreement with the experimental data. Compared with the code equation, the equation in this paper adopts the expression for the dimensionless coefficient, which can more reasonably reveal the bending mechanism of the joint.
The Effect of UV-C Irradiation on the Mechanical and Physiological Properties of Potato Tuber and Different Products
Authors: Lemessa Addis , Popardowski Ernest , Hebda Tomasz , Jakubowski Tomasz
Published: June 2022

Amongst the surface treatment technologies to emerge in the last few decades, UV-C radiation surface treatment is widely used in food process industries for the purpose of shelf life elongation, bacterial inactivation, and stimulation. However, the short wave application is highly dose-dependent and induces different properties of the product during exposure. Mechanical properties of the agricultural products and their derivatives represent the key indicator of acceptability by the end-user. This paper surveys the recent findings of the influence of UV-C on the stress response and physiological change concerning the mechanical and textural properties of miscellaneous agricultural products with a specific focus on a potato tuber. This paper also reviewed the hormetic effect of UV-C triggered at a different classification of doses studied so far on the amount of phenolic content, antioxidants, and other chemicals responsible for the stimulation process. The combined technologies with UV-C for product quality improvement are also highlighted. The review work draws the current challenges as well as future perspectives. Moreover, a way forward in the key areas of improvement of UV-C treatment technologies is suggested that can induce a favorable stress, enabling the product to achieve self-defense mechanisms against wound, impact, and mechanical damage.
Source Model and Seismogenic Environment of the Ms 6.4 Yangbi Earthquake in Yunnan, China—Based on InSAR Observation
Authors: Li Wei , Huang Yutong , Wang Xiaohang , Jiang Xin , Li Xiaotong , Xie Xukang , Wang Qianwen , Yan Haowen
Published: June 2022

On 21 May 2021, an Ms 6.4 earthquake struck Yangbi County, Dali Prefecture, Yunnan Province, China, which is the largest earthquake to hit this area since 1976. In this paper, we obtained the coseismic deformation of the Yangbi earthquake in Yunnan Province based on the interferometric synthetic aperture radar (InSAR) observation. After that, we obtained the fault geometry and slip distribution model of this earthquake via the two-step inversion method. The maximum deformation in the ascending orbit along the line of sight (LOS) direction was 7.3 cm, and the maximum deformation in the descending orbit along the LOS direction was 8.9 cm; the slip distribution model showed that the slip distribution of this earthquake was concentrated at a depth of 1–14 km, and the maximum slip was 0.6 m at a depth of 5 km. Based on the modeling result, it was inferred that the seismogenic fault of this earthquake was a dextral strike-slip fault on the west side of the Weixi-Qiaohou–Weishan fault. Combining the existing geological data and the changes in Coulomb stress caused by this earthquake, the seismic hazard and seismogenic structure in the area near the epicenter were analyzed and discussed, and the results showed that, in the northwest of the Weixi-Qiaohou fault zone, there will be an increased hazard of a future earthquake in the NW trend; thus, we should pay attention to this area.
Numerical Investigation on the Droplet Dispersion inside a Bus and the Infection Risk Prediction
Authors: Yang Yafeng , Wang Yiping , Su Chuqi , Liu Xun , Yuan Xiaohong , Chen Zhixin
Published: June 2022

COVID-19 can be easily transmitted to passengers by inhaling exhaled droplets from the infected person in a bus. Therefore, studying droplet dispersion would provide further insight into the mechanism of virus transmission and predict the risk of infection among passengers on a bus. In this research, a bus equipped with air-conditioning was employed as the research object. To determine the dispersion path, concentration distribution, and escape time of the droplets, computational fluid dynamic (CFD) was applied to simulate the flow field and the droplets’ dispersion. The effect of the air supply rate, the location of vents, and the location of infected persons on the dispersion were discussed. Based on the distribution of droplets in the cabin calculated by CFD, a superposition method was used to determine the number of virus particles inhaled by every individual passenger over a four-hour journey. Then, infection risk was assessed by the Wells-Riley equation for all the passengers in the cabin after the whole journey. The results show that the distribution of droplets in the cabin is greatly influenced by the location of the infected person, and the airflow pattern is highly associated with the air supply rate and the location of vents. The infection risk of passengers located at the droplet dispersion path and the distance from the infected persons less than 2.2 m is over 10%. The increase in the air supply rate could speed up the spread of the droplets but at the same time, it could reduce the infection risk.
Electronic Band Structures of the Possible Topological Insulator Pb2BiBrO6 and Pb2SeTeO6 Double Perovskite: An Ab Initio Study
Authors: Tung Jen-Chuan , Lee Chi-Hsuan , Liu Po-Liang , Wang Yin-Kuo
Published: June 2022

Using the frameworks of density functional theory, we found a new class of three-dimensional (3D) topological insulators (TIs) in Pb2BiBrO6 and Pb2SeTeO6 double perovskites. Our ab initio theoretical calculations show that Pb2BiBrO6 and Pb2SeTeO6 are Z2 nontrivial, and their bandgaps are 0.390 eV and 0.181 eV, respectively. The topology comes from two mechanisms. Firstly, the band inversion occurs at Γ point in the absence of spin-orbit interactions and secondly, the bandgap is induced by the SOC. This results in a larger bandgap for this new class of topological insulators than conventional TI. In Pb2BiBrO6 double perovskites, our slab calculations confirm that the topology-protected surface metallic bands come from the BiBrO4 surface which means that one can build a transport device using Pb2BiBrO6 double perovskites with a PbO layer as an outmost protection layer. The mechanical stabilities such as bulk, shear, Young’s moduli, Poisson’s and Pugh’s ratio, longitudinal, transverse, and average sound velocity, together with Debye temperature are also studied. Our results show that these Pb2AA’O6 (A = Sb and Bi; A’ = Br and I) and Pb2SeTeO6 are mechanically stable.
An Evolutionary Computation Approach for Twitter Bot Detection
Authors: Rovito Luigi , Bonin Lorenzo , Manzoni Luca , De Lorenzo Andrea
Published: June 2022

Bot accounts are automated software programs that act as legitimate human profiles on social networks. Identifying these kinds of accounts is a challenging problem due to the high variety and heterogeneity that bot accounts exhibit. In this work, we use genetic algorithms and genetic programming to discover interpretable classification models for Twitter bot detection with competitive qualitative performance, high scalability, and good generalization capabilities. Specifically, we use a genetic programming method with a set of primitives that involves simple mathematical operators. This enables us to discover a human-readable detection algorithm that exhibits a detection accuracy close to the top state-of-the-art methods on the TwiBot-20 dataset while providing predictions that can be interpreted, and whose uncertainty can be easily measured. To the best of our knowledge, this work is the first attempt at adopting evolutionary computation techniques for detecting bot profiles on social media platforms.
Study on the Microwave Ablation Effect of Inflated Porcine Lung
Authors: Hu Hao , Nan Qun , Tian Zhen , Gao Xiang
Published: June 2022

(1) Background: Microwave ablation (MWA) has an efficient killing effect on primary and metastatic lung cancer. However, the treatment effect will be affected by the air in the lung, which makes it very difficult to accurately predict and control the ablation area; (2) Methods: In this paper, in vitro experiments combined with simulations are used to study the microwave ablation area of inflated porcine lung. The in vitro experiment is divided into inflated group and deflated group, combined with different ablation power (40 W, 50 W, 60 W) and ablation time (100 s, 200 s, 300 s) for experiment, each power and time combination are repeated five times. A total of 90 ablation experiments were performed. The simulation experiment uses COMSOL Multiphysics software to simulate the microwave ablation area of the inflated lung; (3) Results and Conclusions: When the ablation power is 40 W, 50 W, and 60 W, the average long diameter of the deflated group are 20.8–30.9%, 7.6–22.6%, 10.4–19.8% larger than those of the inflated group, respectively; the average short diameter of the deflated group is 24.5–41.4%, 31.6–45.7%, 27.3–42.9% larger than that of the inflated group. The results show that the ablation area of inflated lung is smaller than deflated lung, which is mainly due to the smaller ablation short diameter.
Virtual Synchronous Machine Control of RES Plants in Isolated Power Systems
Authors: Sa’ed Jaser A. , Favuzza Salvatore , Navarro Navia Milagros Amparo , Zizzo Gaetano
Published: June 2022

Because of the increase in renewable energy sources (RESs) share, new control strategies of isolated power systems have been developed to improve the frequency and voltage stability of inverter-interfaced RESs. A voltage source converter (VSC) with a virtual synchronous machine (VSM) is among the most promising control schemes. This paper demonstrates how VSM control of inverter-interfaced RES can be efficiently used to improve the dynamic stability in small isolated power systems. In the proposed analysis, the RESs of a Mediterranean island are assumed interfaced to the grid by VSCs with a swing controller and a vector-current controller (VCC) with two different options for the reference current (RC) to regulate the voltage at the point of common coupling (PCC) and the real power output. The system is modelled in a PSCAD environment, and the behavior of the control is tested in the case of a phase-to-phase fault. The results of the simulations for different scenarios and values for the control parameters show the effectiveness of the control in small isolated grids. Finally, the level of grid power quality is verified via harmonic analysis of the PCC voltage.
Identifying a Correlation among Qualitative Non-Numeric Parameters in Natural Fish Microbe Dataset Using Machine Learning
Authors: Shima Hideaki , Sato Yuho , Sakata Kenji , Asakura Taiga , Kikuchi Jun
Published: June 2022

Recent technical innovations and developments in computer-based technology have enabled bioscience researchers to acquire comprehensive datasets and identify unique parameters within experimental datasets. However, field researchers may face the challenge that datasets exhibit few associations among any measurement results (e.g., from analytical instruments, phenotype observations as well as field environmental data), and may contain non-numerical, qualitative parameters, which make statistical analyses difficult. Here, we propose an advanced analysis scheme that combines two machine learning steps to mine association rules between non-numerical parameters. The aim of this analysis is to identify relationships between variables and enable the visualization of association rules from data of samples collected in the field, which have less correlations between genetic, physical, and non-numerical qualitative parameters. The analysis scheme presented here may increase the potential to identify important characteristics of big datasets.
Wavelet Time-Frequency Analysis on Bridge Resonance in Train-Track-Bridge Interactive System
Authors: Wu Zhaozhi , Zhang Nan , Yao Jinbao , Poliakov Vladimir
Published: June 2022

With the continuous improvement in the operation speed of trains, the impact of train–induced vibration through the track on the bridge is increasingly prominent. In particular, when the loading frequency is the same as or close to the natural frequency of the bridge, the resonant response of the bridge will be activated, which will probably endanger the safety of the operation and the bridge structure. Normally, the traditional method to indicate the appearance of resonant response is to analyze the frequency spectrum of the response through the Fourier transform from its time history. However, it can simply reflect the contribution of different frequency components within a stationary window. Therefore, continuous wavelet transform is adopted on a 2D train–track–bridge interactive system in this article. It illustrates the evolutionary characteristics of different frequencies from the input excitation to the output response during the bridge resonance in the time–frequency domain, compared with the cases when the bridge is nonresonant. Finally, the article demonstrates the feasibility of the method. It concludes that the resonance and quasi–resonance–triggering band accounts for the highly intensified bridge response, while the staggering domination between the steady-state and the transient response is the main phenomenon for the nonresonant bridge. Additionally, within the low–frequency band, the resonant bridge will have a more significant impact on the track subsystem than the train subsystem.
Structural Optimization of Combine Harvester Plate–Shell Undergoing Multi-Source Excitation
Authors: Gu Xinyang , Zhang Ben , Tang Zhong , Zhang Hao , Wang Haoyang
Published: June 2022

As a multi-source vibration machine, the complex vibration of the combine harvester has caused many effects on various components. In this paper, the dynamic response of the plate and shell on the combine harvester is studied, and the influence of various factors on the vibration of the plate and shell is determined. The structure of the plate and shell is optimized, and the scheme of structural optimization that replaces the finite element model with the surrogate model is developed. The structure is designed with Latin hypercube design (LHD), the model of response surface is generated based on the Kriging model, and then the parameters are optimized by a multi-objective genetic algorithm (MOGA). It is realized that the first-order natural frequency of the plate is increased by 14.6% under the same mass, avoiding the resonance range of the main excitation of the machine. At the same time, its dynamic response under the multi-point force is also greatly decreased by 62.4%.
An Automatic Partition Time-Varying Markov Model for Reliability Evaluation
Authors: Kou Linlin , Chu Baiqing , Chen Yan , Qin Yong
Published: June 2022

As the service time of mechanical devices is getting longer and longer, the safe and reliability evaluation during operation is highlighted. Moreover, real-time reliability evaluation with consideration of multi-state performance degradation becomes increasingly important nowadays, since the consequences of sudden failures are more unacceptable than ever before. The Markov process is a commonly used model in multi-state reliability evaluation. However, little research of the Markov model can deal with multi-source monitoring data and time-varying properties of device performance degradation, as well as the scientific state number determination. In this article, a real-time reliability evaluation model based on automatic partition and the time-varying Markov chain is proposed to solve the problems of the scientific state number selection and time-varying properties description with the state transition matrix of the Markov process, together with taking advantage of multi-source information. The effectiveness of the proposed algorithm is demonstrated on the bearing with life-long vibration and temperature data. It shows that the proposed automatic partition time-varying Markov model can decide the state number automatically according to the trend of life-long data, and evaluate real-time reliability based on equipment operating hours and operating status. The result of predicted remaining useful life obtained by the proposed model is more accurate, and it also shows great superiority in conformity with reality.
Performance of Apple Pomace for Gluten-Free Bread Manufacture: Effect on Physicochemical Characteristics and Nutritional Value
Authors: Cantero Leire , Salmerón Jesús , Miranda Jonatan , Larretxi Idoia , Fernández-Gil María del Pilar , Bustamante María Ángeles , Matias Silvia , Navarro Virginia , Simón Edurne , Martínez Olaia
Published: June 2022

Apple pomace has been proposed as a quality enhancer for gluten-free bread, but its composition and physicochemical features differ significantly depending on the apple cultivar. The objective of this article was to characterize apple pomace powder (APP) from certain varieties from the Basque Country and to study the feasibility of adding it to gluten-free bread, focusing on physicochemical and nutritional aspects. APP was obtained by washing, drying and grinding, and it was added at 0, 5, 6 and 8%, together with other ingredients, such as gluten-free flours, corn starch and whey protein. APP had a reddish-grey coloration (L* 56.49 ± 1.39, a* 11.07 ± 0.47, b* 27.69 ± 1.76), pH 4.19 ± 0.15 and Aw 0.235 ± 0.084. Pomace powder was used successfully in higher amounts than experiences reported before. Key physicochemical parameters such as specific volume (≥2.5 cm3/g) and cohesiveness or resilience values (0.538 and 0.378, respectively) suggested good acceptability for gluten-free breads with 8% APP. Additionally, breads were a source of antioxidant potential (437.66 ± 38.95 µM DPPHeq/g APP), fiber (80.13 ± 6.07 g/100 g) and micronutrients such as Cu, Mg, Mn and Fe. In conclusion, local apple varieties are a good source of raw material for gluten-free bread manufacture, which offers a solution for environmental pollution and may contribute to boosting the circular economy.