bluuebunny/crossref_metadata_2025 huggingface dataset:
Differences in the Characteristics of Ischemic and Haemorrhage Stroke Patients with Mechanical Phlebitis
Authors: Siswanti Yeni , Widyawati Ika Yuni , Asmoro Candra Panji
Published: December 2021

Introduction: One of the complications of stroke patients receiving intravenous therapy is mechanical phlebitis. The purpose of this study was to analyze the differences characteristic of stroke patients who experienced mechanical phlebitisMethods: This study was used a comparative descriptive method with a documentation study design. The subjects of this study were stroke patients who experienced mechanical phlebitis from January 2018 until September 2020. The sampling method used total sampling with 92 samples. Data analysis using Chi-squared test.Results: Gender (p = 0.020) had a significant difference with the incidence of mechanical phlebitis in stroke patients. Characteristics of age (p=0.511), history of hypertension (p=0.058), diabetes mellitus (p=0.503), pneumonia (p=0.164), and stroke (p= 0.160) did not have a significant difference with the incidence of mechanical phlebitis in stroke patients.Conclusion: There are differences in gender characteristics in stroke patients who experience mechanical phlebitis.
The Impact of Interactivity, Perceived Effectiveness, Trust, and Experiential Marketing on Online Transportation Customer Loyalty
Authors: Hussein Ananda Sabil , Hapsari Raditha
Published: December 2021

The purpose of this study is to examine the effect of interactivity, perceived effectiveness, trust, and experiential marketing on online transportation customers' loyalty in Indonesia. This study surveyed 264 online transportation customers. Purposive sampling was used to recruit respondents. Partial Least Squares analysis was used to analyze the data in three steps, including inner model analysis, outer model analysis, and hypothesis testing. The hypothesis testing supported seven of the nine hypotheses proposed. The findings of this study indicate that interaction is a significant predictor of online transportation consumer loyalty. The report also discusses the implications of the results and the direction for further research.
A SEMIOTIC ANALYSIS OF SUMPAH POCONG AMONG MADURANESE PEOPLE: A CASE STUDY OF POLAGAN DISTRICT, SAMPANG-MADURA
Authors: Mukarromah Mukarromah
Published: December 2021

Abstract: Sumpah pocong is a tradition that is still performed by the Madurese community, especially in the Polagan Village, Madegan, Sampang. This study aims to seek the meaning contained in sumpah pocong based on the signs in sumpah pocong also the concept of signifier and signified by Ferdinand de Saussure. The method used in this research is descriptive qualitative by utilizing field studies through interviews and direct documentation in Polagan Village. The results of this study indicate that the community has different opinions and views in interpreting sumpah pocong.
THE REPRESENTATION OF SISTERHOOD IN SUSAN GLASPELL'S TRIFLE: PROXEMIC AND KINESIC ANALYSES
Authors: Suwastini Ni Komang Arie , Wahyudiputra Alexei
Published: December 2021

Abstract: Susan Glaspell’s plays have been recognized for its feminist ideologies. The present study traces the representations of the notion of sisterhood in Glaspell’s scrip entitled Trifles by employing Barthes’ semiotics and Fischer-Lichte’s concept of kinesics. Focusing on the gestural and the proxemic signs of the kinesics included in the script, the present study reveals that the notion of sisterhood grows among the female characters in the play through the increasing realization of their similar positions as women in patriarchal society. This development of solidarity among the female characters implies a strong feminist ideology about how women should stand together in facing oppression in male-dominated structures.
THE ROLE OF RENEWABLE ENERGY SOURCES IN REGIONAL TOURISM DEVELOPMENT
Authors: Blazevic Branko
Published: December 2021

In this paper, the author focuses on the fundamental hypothesis that the adoption of a concept of regional sustainable development and the use of renewable energy sources are preconditions to organising an acceptable regional tourism offering based on an eco-philosophy The renewable development of tourism regions is the basic framework for research regarding opportunities for introducing renewable energy sources such as hydro energy, wind power, solar energy, geothermal energy, and biomass energy. The purpose of this paper is to indicate the real opportunities that exist for substituting conventional energy sources with renewable ones and the role of renewables in regional development from economic, environmental and sociological viewpoints. It should also be noted that renewable energy sources have a strong regional importance and can contribute significantly to local employment.
INTERNAL MARKETING FACTORS AND THE PERFORMANCE OF TRAVEL AGENCIES∗
Authors: Avelini Holjevac Ivanka , Bašan Lorena
Published: December 2021

As participants in creating a tourism offering and as initiators of tourist demand, travel agencies represent a key segment of the tourist market. Hence, the business results of these tourism companies will have a direct impact on realising tourism traffic in destinations. This makes it essential to analyse the business results achieved and the performance of travel agencies. The outcome of the analysis of business results and performance, together with the weaknesses and strengths identified in the operations of travel agencies based on an analysis of internal marketing factors, represent a basis for managers in making business decisions, as well as in carrying out analysis and research aimed at achieving enhanced business results and greater performance of travel agencies.
SPECIFIC KNOWLEDGE FOR MANAGING ECOTOURISM DESTINATIONS
Authors: Smolćić Jurdana Dora
Published: December 2021

Management of ecotourism destinations is very demanding because of the specific and interdisciplinary knowledge that is necessary. Great knowledge, which consists of knowledge from human and natural sciences at the same time, emphasizes the need for permanent education, formal and informal of ecotourism destination managers. In should be generally stated that countries which have a great areas and resources for ecotourism development should create a specific program for education about the relevant and specific issues. Besides the availability of natural resources, knowledge is for sure the most important and basic element of ecotourism destination competitiveness improvement. In general these statements are applicable to all destinations which attractiveness arises from the quality and uniqueness of natural resources.
STRATEGIC NETWORKS OF SMALL HOTELS – EVIDENCE FROM CROATIA
Authors: Pivčević Smiljana
Published: December 2021

Most tourism theoreticians and practitioners agree that small hotels present one of the most vital segments of accommodation facilities arguing that they are able to react more promptly and effectively to market changes and capable of offering high-quality, differentiated and personalized services. They also agree that they are facing specific problems arising from their size which can concisely be summed in difficult access to all business resources. Thus, it is believed that their survival and long-term success depend upon their ability to strengthen their market position while preserving their core strengths - independency and flexibility. The main idea of this paper is that networking, especially in horizontal direction, is the solution. To support the idea, an empirical research was conducted with the goal of determining the extent of implementation and the features of networking i.e. cooperation in the small hotel sector in Croatia.
THE FEATURES OF THE NATURIST CAMPING MARKET
Authors: Smolčić Jurdana Dora , Milohnić Ines , Cvelić-Bonifaćić Josipa
Published: December 2021

This report examines the characteristics, the current situation and the perspectives of the European naturist camping market with the aim of defining future strategies and tactics for further development in this field. The first part engages with the definition of naturism, its historical evolution and the system of European demand for naturism by looking at the main European naturist associations, clubs and largest specialised tour operators and tour agencies. Additionally, this thesis examines the direction of the naturist offer over the past 10 years in Europe and Croatia. By means of a comparative analysis of the characteristics of the Croatian demand for camping and Croatian demand for naturist camping, trends, similarities and differences between the two were established. On the basis of this research, the CARE method was used, which provides guidance on how to Create, Amplify, Reduce and Eliminate certain aspects of the supply of naturism in order to define future strategies and tactics for achieving competitiveness on the naturist market.
TRENDS ON THE TOURISM LABOUR MARKET
Authors: Bečić Emira , Črnjar Kristina
Published: December 2021

Tourism is an important sector in the Croatian economy. To retain its unique position in global markets, Croatian tourism has to compete with other world destinations and to attract travellers worldwide. This will not be possible without efficient human resource development policies and practices. The main problems in tourism are very similar across countries: low pay, very high demand for staff flexibility and mobility, high staff turnover, high share of informal employment arrangements and persistent skill shortages.
BASICS FOR APPLYING A CONTEMPORARY CONCEPT FOR HUMAN RESOURCE MANAGEMENT∗
Authors: Ćamilović Slobodan
Published: December 2021

In the process of organizational adaptation to environmental demands, primarily through the anticipated outputs, human resources play a key role. The procuring of necessary human resources, their working commitment and development, are the basic assignments of the management of human resources. The appliance of a contemporary concept of management of human resources, based on theoretical and practical cognizance of successful organizations, contributes to a successful execution of these and other assignments. In order to develop such a concept it is necessary to provide, in addition to the relevant basics, a whole chain of professional and managerial activities.
Median TiMESH colporrhaphy with transobturator ligature fixation of the vaginal cuff as a method of surgical treatment for post-hysterectomy pelvic hernia
Authors:   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Ishchenko A.I. , Ishchenko A.A. ,   National Medical Research Center “Treatment and Rehabilitation Center”, Moscow, Russian Federation, Khokhlova I.D. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Dzhibladze T.A. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Gorbenko O.Yu. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Asambaeva A. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Lanchinskiy V.I. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
Published: December 2021

The analysis of clinical observation of 4 patients aged 68–78 years with post-hysterectomy pelvic hernia who were operated with the use of titanium implants and transobturator ligature fixation of the vaginal cuff according to the original technique is presented. Dynamic follow-up for 3–12 months after surgery showed the absence of pelvic organ prolapse during gynecological examination, Valsalva maneuver, and transperineal ultrasound. The questionnaire survey of patients showed their satisfaction with the results of surgery and improvement of their quality of life. Conclusion. Median TiMESH colporrhaphy with transobturator ligature fixation of the vaginal cuff in patients of elderly and senile age with post-hysterectomy pelvic hernia when slightly prolonging the operation duration contributes to strengthening and firm consolidation of the vaginal walls, elevation of the vaginal cuff and adjacent organs, improving the condition of the surgical scar and, therefore, improving patients’ quality of life and preventing disease recurrence. Key words: post-hysterectomy pelvic hernia, median TiMESH colporrhaphy, transobturator ligature fixation of the vaginal cluff
Gaspar Núñez Delgado y el VII duque de Medina sidonia
Authors: Cruz Isidoro Fernando
Published: December 2021

Analizamos la talla de un Cristo con la cruz a cuestas, de bulto redondo, que el escultor protobarroco Gaspar Núñez Delgado (ca. 1555-1606) realizó en 1575 para el VII duque de Medina Sidonia, y que resulta su primera obra documentada. Al parecer, se dispuso en la capilla de su palacio en Sevilla, junto a otras dos esculturas que el noble le encargó, determinando una novedosa iconografía en la ciudad. Se realiza una propuesta de identificación
Genomic Responses Associated with Drought Stress in Walnut as Revealed Transcriptome Sequencing
Authors: Sadat-Hosseini Mohammad , Bakhtiarizade Mohammad Reza , Boroumand Naser , Tohidfar Masoud , Aliniaeifard Sasan , Vahdati Kourosh
Published: December 2021

Walnut production is challenged by abiotic stresses. We investigated the leaf transcriptome responses of walnut under control and drought stress in 9 and 18 days. We identified 921, 1035 differentially expressed genes (DEGs) between control and drought stress groups in 9 and 18-day, respectively. In control and drought stress conditions DEGs were significantly enriched into the abscisic acid biosynthesis, regulation of stomata closure, leaf morphogenesis, carbohydrate metabolism, oxidative stress, cell wall macromolecule catabolism, and secondary metabolite biosynthesis pathways. We confirmed our RNA-Seq data using quantitative real-time PCR (qPCR) of six candidate genes. Our results indicated that more complicated transcript regulation of drought responses following prolong exposure to drought stress. In general, walnut activated more tolerance mechanisms 18 days after drought stress. Findings of this research would be useful for future studies on breeding for drought tolerance of Persian walnut and related species.
Bilingual experiences induce dynamic structural changes to basal ganglia and the thalamus
Authors: Korenar Michal , Treffers-Daller Jeanine , Pliatsikas Christos
Published: December 2021

Bilingualism has been linked to structural adaptations of subcortical brain regions that are important nodes in controlling of multiple languages. However, research on the location and extent of these adaptations has yielded variable patterns. Existing literature on bilingualism-induced brain adaptations has so far largely overseen evidence from other domains that experience-based structural neuroplasticity often triggers non-linear adaptations which follow expansion-renormalisation trajectories. Here we use generalised additive mixed models (GAMMs) to investigate the non-linear effects of quantified bilingual experiences on the basal ganglia and thalamus in a sample of bilinguals with wide range of bilingual experiences. Our results revealed that volumes of bilateral caudate nuclei and accumbens were positively related to bilingual experiences in a non-linear pattern, with increases followed by decreases, in the most experienced bilinguals, suggesting a return to baseline volume at higher levels of bilingual experience. Moreover, volumes of putamen and thalamus were positively linearly predicted by bilingual experiences. The results offer the first direct evidence that bilingualism, similarly to other cognitively demanding skills, leads to dynamic subcortical structural adaptations which can be nonlinear, in line with expansion-renormalisation models of experience-dependent neuroplasticity.
Discovery of a conserved rule behind the assembly of β-barrel membrane proteins
Authors: Shiota Takuya , Germany Edward , Ding Yue , Imai Kenichiro , Bamert Rebecca , Dunstan Rhys , Nakajima Yukari , Lai Xiangfeng , Webb Chaille , Stubenrauch Christopher , Hidaka Kentaro , Thewasano Nakajohn , Tan Khershing , Shen Hsin-Hui , Lithgow Trevor
Published: December 2021

Gram-negative bacteria, mitochondria and chloroplasts contain β-barrel outer membrane proteins (OMPs). Most OMPs have a “β-signal” imprinted in the final β-strand. In Gram-negative bacteria, the β-barrel assembly machinery (BAM) complex recognize the β-signal for the folding and membrane insertion of the OMP. Here, we identified the “-5 signal”, a novel signal existing in the fifth β-strand from the C-terminus (-5 strand) responsible for the insertion step of the assembly process. We further identified the receptor for the -5 signal as BamD. BamD can recognize both β-signal and -5 signal, marshalling the OMP for assembly. There is sequence similarity in of both signals observed also in mitochondrial OMPs. Therefore, we propose the “-5 rule” repeating a similar sequence in the -5 and last strand, as a conserved feature of the OMP assembly process in bacteria and eukaryotes.
New Modification of Vertical Muscle Transposition to Enhance Abducting Force in Sixth Nerve Palsy
Authors: Heede Santa , Kovalevskaya Irina , Astle William , Valeina Sandra , Griebenow Uwe
Published: December 2021

Purpose:Since 1907, multiple transposition procedures have been established for the treatment of abducens paralysis. In this study, we try to determine where the transposed muscle should be reattached in order to increase the tangential force necessary to improve abduction.Methods:Retrospective case review of 12 consecutive patients with abducens paralysis. All patients underwent the transposition procedure between 2016 and 2019.Vertical rectus muscles are transposed to the insertion of lateral rectus muscle: The temporal parts are joined and sutured to the sclera on top of the lateral rectus muscle in the middle of the insertion. The nasal parts are sutured to the sclera following the spiral of Tillaux. The muscle junction suture is placed 8 mm from the insertion: The temporal parts of the vertical muscles bellies are joined and sutured to the lateral rectus muscle. A full tendon transposition was performed on 11 patients, a half tendon transposition procedure on one patient. The minimum follow-up was 3 months.Results:The mean preoperative deviation was ET of 37° (range: ET 24° to ET 51°). The mean preoperative abduction limitation was 5 mm from midline (range: -7 to -1mm). The postoperative mean deviation was ET of 2° PD (range: 0 to ET 5°). The postoperative mean abduction improvement was 5mm past midline (range: +2 to +6mm). There were no complications, or signs of anterior segment ischemia. Conclusions:To achieve the maximal abductive force from the transposed muscles, we suggest that the vertical muscles be reattached as close as possible to the middle of the lateral rectus insertion.
Cellulose/Exosome Nanocarrier for Improved Prolonged Release of 5-Fluorouracil: Preparation, Characterization, Drug Release Behavior and Cytotoxicity
Authors: Saeidifar Maryam , Seyedahmadi Mobina , Javadpour Jafar , Rezaei Hamid Reza
Published: December 2021

Designing of nanoparticle drug delivery systems and improving the efficacy of anticancer drugs are a great deal of effort in the recent years. In this study, a novel biocompatible nanocarrier based on bacterial cellulose (BC) in presence of exosome (Exo) was prepared to controlled release of 5-fluorouracil (5-FU), (5-FU.Exo@BC). The physicochemical properties of 5-FU.Exo@BC was characterized using field emission scanning electron microscopy (FESEM), Differential Scanning Calorimetry (DSC), Fourier-transform infrared spectroscopy (FTIR), and X-ray Diffraction (XRD) techniques that confirmed the successful preparation of 5-FU.Exo@BC. The release behavior of 5-FU.Exo@BC compared to 5-FU and 5-FU@BC demonstrated a significant sustained release during 162 h. The release mechanism of the above three systems followed Korsmeyer-peppas with non-Fickian diffusion for 5-FU@BC and 5-FU.Exo@BC. In addition, the viability of HT-29 cells (human colon cancer cell line), towards BC, 5-FU@BC and 5-FU.Exo@BC indicated the promising efficacy of 5-FU into 5-FU.Exo@BC. Subsequently, the prepared bio-nanocomposite could be proposed as a potential drug delivery system with effective controlled-release function.
Superabsorbent Polymer With Excellent Water/Salt Absorbency And Water Retention, And Fast Swelling Properties For Preventing Soil Water Evaporation
Authors: Tian Haizhou , Cheng Sha , Zhen Jianghong , Lei Ziqiang
Published: December 2021

Superabsorbent polymers have important applications in many fields, but insufficiency of water/salt absorbency, water retention, and swelling rate limit its application development. Herein, we fabricated HEC-g-P (AA-co-AMPS)/laterite by aqueous solution polymerization, the structure and morphology of the superabsorbent polymer were characterized by FTIR, SEM and TG/DTG. The optimal water absorbency of the superabsorbent polymer were 1294 g/g, 177 g/g, and 119 g/g in distilled water, tap water, and 0.9 wt% NaCl solution, respectively. The superabsorbent polymer had good water retention and re-swelling properties at different temperatures, and fast water absorption rate, and reached swelling equilibrium at 5 min. The swelling mechanism of the superabsorbent polymer was explained by the pseudo-second-order swelling kinetics model and Ritger-Peppas model. The effect of the amount of hydrogel on the water evaporation rate in soil was studied, and it had a good effect.
Whether Gastrorenal Shunt Embolization Would Benefit the Outcomes of Post Transjugular Intrahepatic Portosystemic Shunt
Authors: Zhao Dongmei , Wang Mingquan , Chen Guosheng , Zhang Guobing , Zhang Chaoxue , Li Jiabin
Published: December 2021

Background & Aim: Whether the spontaneous portosystemic shunts in cirrhosis who require embolization during transjugular intrahepatic portosystemic shunt (TIPS) remains a therapeutic controversial. This study was retrospectively conducted to evaluate the effectiveness of the gastrorenal shunts (GRS) embolization in cirrhosis post-TIPS。Methods: 70 cirrhotic patients who underwent TIPS in a tertiary-care center were included, of which 43 patients had no GRS and 27 had GRS with embolization during TIPS placement. Then, to assess the outcomes of embolization of GRS on post-TIPS hepatic encephalopathy (HE), clinical relapse, mortality and shunt dysfunction.Results: During a median follow-up period of 497.01 days, 25 patients (35.7%) experienced HE, of 14 patients in GRS group and 11 in another (p = 0.026). Within 50 days after TIPS, 12 patients performed initial HE in GRS group while 6 in the reference group (p < 0.001). After TIPS of 150th to 200th, one in the former group and five in another experienced HE (p < 0.001). However, there was no significant difference in the 1-year cumulative risk of HE (p = 0.287). Meanwhile, during the 2-year follow-up, the patients performed lower incidence of ascites after GRS embolization with TIPS (p < 0.002). And there was no difference in rebleeding, mortality and shunt dysfunction. Conclusions: TIPS with GRS embolization appeared to be a safe and efficacious procedure in the treatment of portal hypertension with concomitant GRS. Furthermore, the procedure seemed to reduce the recurrences of ascites for a long term observation.
Systematic Investigation of the Clinical Significance and Prognostic Value of the CBXs in Esophageal Cancer
Authors: Hou Jun , Yang Yinfeng , Gao Honglei , Liu Qiwei , Ding Ran , Chen Lijun , Kan Hongxing
Published: December 2021

Background: Esophageal cancer (ESCA), one of the most aggressive malignant tumors, has been announced to be the ninth most common cancer and the sixth leading cause of cancer-related death in the world. Chromobox family members (CBXs) are important epigenetic regulators which are related with the transcription of target genes. The role of CBXs in carcinomas has been reported in many studies. However, the function and prognostic value of different CBXs in Esophageal cancer are still largely unknown.Methods: In this article, we first performed differential expression analysis through several methods including Oncomine and Gene Expression Profiling Interactive Analysis. The results led us to determine the differential expression of CBXs in pan-cancer, especially ESCA. Then we evaluated the prognostic value of different CBX mRNA expression in patients with ESCA through the Kaplan-Meier plotter and the Human Protein Atlas database. In addition, we used cBioPortal to explore all genetic alterations and mutations in the CBXs in ESCA. Simultaneously, the correlation between its expression and the level of immune infiltration of ESCA was visualized by TIMER. Finally, the biological function of CBXs in ESCA is obtained through Biological Enrichment Analysis including GO and KEGG.Results: The expression levels of CBX3/4/5 and CBX8 in ESCA tissues increased significantly and the expression level of CBX7 decreased through differential expression analysis. Additionally, CBX1 is significantly related to the clinical cancer stage and disease-free survival (DFS) of ESCA patients. The high mRNA expression of CBX4 is related to the short overall survival (OS) of patients with esophageal squamous cell carcinoma, and the high mRNA expression of CBX3/7/8 is related to the short OS of patients with esophageal adenocarcinoma, indicating that CBX1/3/4/7/8 may be a potential prognostic biomarker for the survival of ESCA patients. Besides, the expression of CBXs is significantly related to the infiltration of a variety of immune cells, including six types of CD4+ T cells, macrophages, neutrophils, B cells, CD8+ T cells and dendritic cells in esophageal cancer. Moreover, we found that CBXs are mainly associated with the inhibition of cell cycle and apoptosis pathway. Further, enrichment analysis indicated that CBXs and correlated genes were enriched in mismatch repair, DNA replication, cancer pathways, and spliceosomes.Conclusions: Our research may provide new insights into the choice of prognosis biomarkers of the CBXs in esophageal cancer.
Curcumin for Attention Deficit Hyperactivity Disorder: a Behavioral Preliminary Investigation
Authors: Macedo Lélia Lilianna Borges de Sousa , Antunes Flavia Tasmin Techera , Alvarenga Willyane de Andrade , Batista Mara Cristina Carvalho , de Moura Mayara Storel Beserra , Farias Mariane Nunes Lima , Caminski Emanuelle Sistherenn , Dallegrave Eliane , Grivicich Ivana , de Souza Alessandra Hubner
Published: December 2021

Background: Curcumin has protective actions in neuropsychiatric disorders. Its mechanism of action is associated with the restoration of catecholaminergic balance, reduction of oxidative/nitrosative stress, protection against inflammation, and neuroprotection. Objective: In a first approach, the study presents an empty review of the potential effect of curcumin on cognitive performance in attention deficit hyperactivity disorder (ADHD).Methods: On a second moment, seeing the scarcity of studies and knowing that ADHD is related to hyperactive and anxious behavior, 20 spontaneously hypertensive Wistar rats (SHR) were divided into groups that received water (1 mg/kg/day), curcumin (50 mg/kg/day), or methylphenidate (1 mg/kg/day) for 42 days. Behavioral tests to assess activity (Open Field test), anxiety and impulsivity (Elevated Plus Maze, and Social Interaction), and memory (Y Maze and Object Recognition Test) were performed. Results: Animals treated with curcumin showed less anxious and hyperactive behavior. Related to the memory, the results can be related to hyperactivity. Conclusion: Thus, the data suggest that the treatments used here can beneficially modulate the anxious and hyperactive behavior of SHR.
Contralateral Eye Study On The Characteristics of Corneal Aberration In Patients With Bilateral Keratoconus And Unilateral Corneal Vogt’s Striae
Authors: Li Jing , Zhang Yaohua , Li Yong , Cai Yan , Du Jing , Liu Jianguo , Wei Shengsheng
Published: December 2021

Purpose: To assess the corneal high-order aberration(HOA) and its correlation with corneal morphological parameters in patients with bilateral keratoconus (KCN) and unilateral Vogt’s striae.Methods: A total of 168 eyes of 84 patients with KCN, whose corneas had definite signs of unilateral Vogt’s striae were enrolled. Corneal HOA and morphological parameters were measured using Pentacam HR.Results: The corneal morphological parameters between KCN eyes with and without Vogt’s striae were evidently different (P < 0.001). The 3rd coma 90°, 4th spherical aberration, 5th coma 90°, RMS (total), and RMS (HOA) in the front, back surfaces and total cornea in KCN eyes with Vogt’s striae were significantly higher than those in KCN eyes without Vogt’s striae (P < 0.001). In KCN eyes with Vogt’s striae, the 3rd coma 90° and 4th spherical aberration in the front surface and total cornea were negatively correlated with K1, K2, Km, Kmax, ACE, and PCE (P < 0.05). The 3rd coma 90° , 4th spherical aberration in back surface and RMS (total), RMS (HOA) in the front, back surfaces, total cornea were positively correlated with K1, K2, Km, Kmax, ACE, and PCE (P < 0.05).Conclusions: Corneal HOA especially vertical coma and spherical aberration may increase when Vogt’s striae appeared in KCN eyes. The scale of increase was significantly related with changes in corneal shapes.
Waste Treatment Innovation For Infusion Bottle Using Soil Solution
Authors: Marsum Marsum , Sunarto Sunarto , Widodo Widodo , khayan khayan , Wardoyo Slamet
Published: December 2021

Disposal of medical or clinical waste into the environment can cause nosocomial and other environmental pollution. Treatment of medical or clinical waste requires modern technology and very high processing costs. Medical waste treatment requires innovation in processing medical waste to be easy to apply in health care facilities. For this reason, it is necessary to innovate antibacterial methods to clean bacteria. This study used an experimental design using a completely randomized design. The treatment was carried out by rinsing with sterile distilled water seven times, using 45% soil with a contact time of 2 minutes. Experiments in the study were carried out twice. The effect of treatment on decreasing the number of bacteria used a mathematical model of Multiple Linear Regression. The results show that the disinfection of infusion bottles is contaminated with bacteria. When using water only requires rinsing up to 6 times, it is sufficient to rinse only once if using a soil solution. Disinfection of infusion bottles contaminated with bacteria using soil solution was able to reduce the number of bacteria by 98%.
Long-Term Outcome of Idiopathic and Acquired Dystonia After Pallidal Deep Brain Stimulation: A Case Series
Authors: Tai Chun-Hwei , Chou Sheng-Che , Lin Chin-Hsien , Lee Wang-Tso , Wu Ruey-Meei , Tseng Sheng-Hong
Published: December 2021

BACKGROUND

Among dystonia patients receiving globus pallidus internus (GPi) deep brain stimulation (DBS), long-term outcomes remain to be established.
OBJECTIVE

To report the long-term outcome of GPi DBS in a patient cohort with idiopathic and acquired dystonia.
METHODS

In this long-term follow-up cohort, there were 4 patients with idiopathic dystonia and 2 patients with acquired dystonia. The Burk-Fahn-Marsden Dystonia Rating Scale (BFMDRS) was used to evaluate 6 consecutive patients preoperatively and at 6 months, 12 months, and the last follow-up. The relationship between etiology and clinical improvement was analyzed. Stimulation parameters were evaluated for similarities and differences among these patients.
RESULTS

The mean follow-up of our cohort was 65.3 months (median 40.5 months). The average improvement in BFMDRS (mean ± SEM) was 56% ± 7.6, 67% ± 6.8 and 66% ± 9.7 at 6 months, 12 months, and last follow-up, respectively. There was greater improvement during long-term follow-up in the 4 patients with idiopathic dystonia than in the 2 patients with acquired dystonia. The 2 most ventral electrodes (contact 0 and 1) were activated in all 11 leads in this cohort. The average stimulation intensity, pulse width and frequency were 2.0 ± 0.24 mA, 252 ± 43 µs, and 99 ± 6.0 Hz, respectively.
CONCLUSION

Isolated dystonia, either monogenetic or idiopathic, usually responds better to GPi DBS than does acquired dystonia. Selection of patients by dystonia etiology, accurate placement of DBS leads in GPi targets, and proper stimulation programming are crucial to achieve better long-term outcomes.
Diospyros Kaki Leaves Decoction Phytochemical Characterization and Bioactivities Evaluation: LC-MS-Qtof Identification, Antioxidant Activity, Enzyme Inhibition and Cytotoxicity Toward HepG2 and Mcf-7 Cell Lines
Authors: Ressaissi Asma , Mannai Amna , Ben-Attia Mossadok , Serralheiro Maria Luísa , El-Bok Safia
Published: December 2021

Diospyros kaki known as Persimmon has played an important role in Chinese medicine, and its leaves are used in pharmaceuticals, cosmetics, and beverages due to their biological properties. The aim of this study was to evaluate chemical composition, antioxidant activity, enzyme inhibition. The main compounds of Diospyros kaki leaves decoctions were identified using high-resolution liquid chromatography – high-resolution tandem mass spectrometry (LC-HRMS-MS) interfaced with a Quadrupole Time-of-Flight (Q-tof). The obtained results showed that the aqueous extract had a high content of total phenolsand flavonoids and showed strong antioxidant activity (EC50 between 3.79±0.19 and 12.05±0.11µg/mL). In addition, these extracts were able to inhibit3-hydroxy-3-methylglutaril-CoA (HMG-CoA) reductase and acetylcholinesterase (IC50 ranging from 58.35±0.69 to 210.21±28.9 µg/mL). The cytotoxicity against human liver cells HepG2 and breast MCF7 cell lines was also evaluated. No cytotoxicity to HepG2 and MCF7 cells was detected. These results indicate that Diospyros kaki leaves could be considered as attractive source of health-promoting ingredients and a promising plant for the development of new functional foods and pharmaceutical products.
Cubesat Constellations Provide Enhanced Crop Phenology And Digital Agricultural Insights Using Daily Leaf Area Index Retrievals.
Authors: Johansen Kasper , Ziliani Matteo G. , Houborg Rasmus , Franz Trenton E. , McCabe Matthew F.
Published: December 2021

Satellite remote sensing has great potential to deliver on the promise of a data-driven agricultural revolution, with emerging space-based platforms providing spatiotemporal insights into precision-level attributes such as crop water use, vegetation health and condition and crop response to management practices. Using a harmonized collection of high-resolution Planet CubeSat, Sentinel-2, Landsat-8 and additional coarser resolution imagery from MODIS and VIIRS, we exploit a multi-satellite data fusion and machine learning approach to deliver a radiometrically calibrated and gap-filled time-series of daily leaf area index (LAI) at an unprecedented spatial resolution of 3 m. The insights available from such high-resolution CubeSat-based LAI data are demonstrated through tracking the growth cycle of a maize crop and identifying observable within-field spatial and temporal variations across key phenological stages. Daily LAI retrievals peaked at the tasseling stage, demonstrating their value for fertilizer and irrigation scheduling. An evaluation of satellite-based retrievals against field-measured LAI data collected from both rain-fed and irrigated fields shows high correlation and captures the spatiotemporal development of intra- and inter-field variations. Novel agricultural insights related to individual vegetative and reproductive growth stages were obtained, showcasing the capacity for new high-resolution CubeSat platforms to deliver actionable intelligence for precision agricultural and related applications.
Placebo Analgesia Changes on Self-Pain and Empathy for Pain: Influences of Event-Related EEG Oscillations, Heart Rate Variability, and Personality
Authors: De Pascalis Vilfredo , Vecchio Arianna
Published: December 2021

We induced placebo analgesia (PA), a phenomenon explicitly attenuating the self-pain feeling, to assess whether this resulted in reduced empathy pain when witnessing a confederate undergoing such pain experience. We recorded EEG and electrocardiogram during a painful control and PA treatment in healthy adults who rated their experienced pain and empathy for pain. We derived HRV changes and, using wavelet analysis of non-phase-locked event-related EEG oscillations, EEG spectral power differences for self-pain and other-pain conditions. First-hand PA produced a reduction of self-pain and self-unpleasantness, whereas we observed only a slight decrease of other unpleasantness. We derived linear combinations of HRV and EEG band power changes significantly associated with self-pain and empathy for pain changes using PCAs. We found that relative HR-slowing together with decreased midline ϑ-band (4-8 Hz) power directly influenced self-pain reduction and, indirectly, through chained mediating effects of the Behavioral Inhibition System and Fight-Flight-Freezing System traits. In the other-pain condition, we detected a direct influence of the midline β2-band (22-30 Hz) power reduction on the other-pain decline with a positive mediating role of Total Empathic Ability. These findings suggest that PA modulation of first-hand versus other pain relies on functionally different physiological processes involving different personality traits.
The effect of chemotherapy on the complication rates of implant and free flap breast reconstruction: A Systematic Review
Authors: Seth Ishith , Bulloch Gabriella , Gibson Damien , Seth Nimish , Hunter-Smith David J , Rozen Warren M
Published: December 2021

Purpose

This study investigated the impact of chemotherapy on complication rates of implant and free flap breast reconstruction. The effect of timing and dosage of chemotherapy in minimizing the breast reconstruction surgery (BRS) complications were also investigated.
Methods

PRISMA guidelines were used to search relevant studies published from January 2009 to September 2021. Quality of selected studies were assessed using GRADE assessment and risk of bias was performed using Cochrane Collaboration’s tool and ROBINS-I. Rates of major and minor complications of neoadjuvant systemic therapy (NST) and adjuvant systemic therapy (AST) were compared by t-test using GraphPad Prism v.9.3.0 and P value <0.05 was considered statistically significant.
Results

A total of 19 studies comprising 49,217 patients were included. The GRADE assessment showed low risk of bias and good quality across studies. Three-hundred and twenty patients had implant reconstruction, 3,172 had flap reconstruction and 46,062 had both flap and implant reconstruction surgery. There was no significant difference in complication rates of patients between flap reconstruction surgery and implants. (P=0.4) In all studies, total complication rates for post-chemotherapy BRS patients was 46.03% compared to 32.49% without chemotherapy (P=0.09). Overall major complications rate was 14.5% (P=0.61) with NST and 21.1% (P=0.69) with AST. Minor complications rate was 28.8% (P=0.97) with NST and 39.5% (P=0.59) with AST. Complication rate of NST was lower than AST, but not statistically significant (P=0.64). No significant correlation was found between timing/duration of chemotherapy and rates of BRS complications (P=0.76).
Conclusion

No significant difference in BRS complications with and without chemotherapy was established. Despite these results suggesting little difference between NST and AST or chemotherapy in BRS complications, prospective control studies are currently limited, and more are necessary to better inform surgeons and their patients.
Molecular Mechanism of Interaction Between Fatty Acid Delta 6 Desaturase and Acyl-CoA by Computational Prediction
Authors: Cui Jie , Chen Haiqin , Tang Xin , Zhang Hao , Chen YongQ , Chen Wei
Published: December 2021

Enzyme catalyzed desaturation of intracellular fatty acids plays an important role in various physiological and pathological processes related to lipids. Limited to the multiple transmembrane domains, it is difficult to obtain their three-dimensional structure of fatty acid desaturases. So how they interact with their substrates is unclear. Here, we predicted the complex of Micromonas pusilla delta 6 desaturase (MpFADS6) with the substrate linoleinyl-CoA (ALA-CoA) by trRosetta software and docking poses by Dock 6 software. The potential enzyme-substrate binding sites were anchored by analysis of the complex. Then, site-directed mutagenesis and activity verification clarified that W290, W224, and F352 were critical residues of the substrate tunnel and directly bonded to ALA-CoA. H94 and H69 were indispensable for transporting electrons with heme. H452, N445, and H358 significantly influenced the recognition and attraction of MpFADS6 to the substrate. These findings provide new insights and methods to determine the structure, mechanisms and directed transformation of membrane-bound desaturases.
Mechanical Properties of Tibetan Rubble Stone Masonry Under Uniaxial Compression
Authors: Wang Yu , Zhou Tiejun , Wang Ruheng , Wang Yuan
Published: December 2021

Basic mechanical properties of Tibetan rubble stone masonry, a unique architectural structure in western China, may affect the bearing capacity of architectural structures. In this study, a compression test was carried out on a Tibetan rubble prism to investigate its failure mechanism and stress-strain characteristics under uniaxial compression. Based on the experimental results, we obtained two simple compression constitutive models for Tibetan rubble stone masonry, established equations applicable to predicting the compressive strength of Tibetan rubble stone masonry, and obtained a relationship between compressive strength and the elasticity modulus through a regression analysis.
Influence of Wear Volume on Surface Quality in Grinding Process Based on Wear Prediction Model
Authors: Cao Wei , Han Zhao , Chen Ziqi , Jin Zili , Wu Jiajun , Qu Jinxiu , Wang Dong
Published: December 2021

In the grinding process, the workpiece would not only be cut by abrasive grains, but also have adhesive wear caused by high temperature and heavy load, which makes the surface quality of the workpiece worse. In this paper, a wear test method considering speed, force, wear coefficient, temperature and hardness was proposed. A new wear prediction physical model was established based on finite element method and numerical simulation technology. The wear test was carried out on a grinding machine. The comprehensive research on the relationship between force, temperature, surface morphology and wear volume of grinding process was studied. The relationship between workpiece speed, grinding depth, cooling lubrication conditions and wear volume of grinding process was studied. The results show that the wear model can achieve numerical prediction and trend prediction of grinding temperature, surface profile and wear volume, the relative errors between the theoretical and actual values of wear and grinding temperature are 9.84% and 2.07% respectively. This study provides a support for wear prediction and surface quality control of grinding process from the perspective of temperature and micro material removal form.
Usefulness of the modified hemophagocytic syndrome diagnostic score as a prognostic factor in lung transplantation patients
Authors: Choi Ji Yeon , Kim Song Yee , Lee Sang Hoon , Woo A La , Young Seung Hyun , Leem Ah Young , Kim Eun Young , Chung Kyung Soo , Jung Ji Ye , Kang Young Ae , Kim Young Sam , Lee Jin Gu , Paik Hyo Chae , Park Moo Suk
Published: December 2021

Background: Lung transplantation (LTX) is an established treatment for end-stage lung disease; however, the post-LTX mortality rate remains high. This study aimed to evaluate the prognostic value of the modified reactive hemophagocytic syndrome diagnostic score (mHScore) and its individual components on mortality after LTX.Methods: We retrospectively analyzed 294 patients who underwent LTX at Severance Hospital, Yonsei University, Korea, from January 2012 and December 2020, and classified them into high (n=114, mHScore > 104.0) and low mHScore (n=180, mHScore ≤ 104.0) groups. Triglyceride, ferritin, serum glutamic oxaloacetic transaminase, fibrinogen, and cytopenia were used to calculate the mHScore. We compared baseline characteristics and mortality rates as LTX prognostic factors.Results: The high mHScore group had significantly more cytopenia and higher ferritin, triglyceride, lactate dehydrogenase, and C-reactive protein levels than the low mHScore group. The mortality rate was significantly higher in the high than in the low mHScore group (hazard ratio, 4.429, p < 0.001). Multivariate regression analysis revealed that a high mHScore was significantly associated with postoperative mortality, even after adjusting for other confounding factors. A high mHScore was also associated with postoperative complications.Conclusions: The mHScore can be used to estimate post-LTX prognosis and predict postoperative mortality.
Depression And HIV/TB In Southern Africa: A Mixed Method Evaluation of An Integrated Primary Care Mental Health Programme In Eswatini
Authors: Putnis Nina , Riches Nick , Nyamayaro Archibald , Boucher Darah , King Rebecca , Walker Ian , Burger Alett , Southworth Paul , Mwanjali Violet , Walley John
Published: December 2021

Background: Depression and comorbidity with chronic illnesses is common in Southern Africa, yet there are major treatment gaps. This study evaluates the intervention ‘Healthy Activity Program’ to bridge this gap, which involves training non-specialist nurses in depression: including identification, counselling based on behavioural activation theory and structured referral. This intervention aims to be integrated into routine primary healthcare services for HIV/TB. The patient cohort were people living with HIV and/or tuberculosis (TB) (PLHIV/TB) in rural Eswatini. Aims: To assess the feasibility and acceptability of this intervention and concepts of depression in this setting.Methods: This is a pragmatic mixed methods evaluation of a pilot integrated service.Results: 324 PLHIV/TB were screened for depression, with 19% (62/324) screening positive. Attendance to counselling declined over time, with 16/62 attending the minimum 5 sessions. Qualitative results indicated acceptability, yet concerns around feasibility. Conclusions: The ‘Healthy Activity Program’ represents a promising option to manage the treatment gap for depression in PLHIV/TB. However, task-shifting onto non-specialist healthcare professionals with the aim to integrate care for these conditions in primary care, without increasing staff capacity, is a barrier to implementation. Realistic and pragmatic assessments of capacity and workforce are essential.