bluuebunny/crossref_metadata_2025 huggingface dataset:
Hydraulic Pressure-Flow Rate Control of a Pallet Handling Robot for an Autonomous Freight Delivery Vehicle
Authors: Masood Khayyam , Dauptain Xavier , Zoppi Matteo , Molfino Rezia
Published: August 2020

The current paper presents an upgrade of a pre-installed hydraulic system for the operation of a pallet handling robot for a freight delivery vehicle known as FURBOT (freight urban robotic vehicle). The automated forklift installed on FURBOT for loading/unloading of cargo is powered with the help of hydraulics. The previous hydraulic system worked via a classical approach with a fixed displacement pump and a bypass valve, making it work on full power when in use. An alternative design was proposed, simulated and installed on FURBOT; it uses a fixed displacement pump and changes the rotation speed in real time using a pressure sensor. Novelty was attained with the use of gear pumps for said scenario. A control algorithm is implemented in the processing unit for controlling the speed of the motor driving the pump. The main advantage of this approach is better use of energy for the vehicle’s battery. The aim of this research is to control both the speed and maximum force exerted by the actuators with the help of a single sensor and an inexpensive pump.
Fifth-Generation District Heating and Cooling Substations: Demand Response with Artificial Neural Network-Based Model Predictive Control
Authors: Buffa Simone , Soppelsa Anton , Pipiciello Mauro , Henze Gregor , Fedrizzi Roberto
Published: August 2020

District heating and cooling (DHC) is considered one of the most sustainable technologies to meet the heating and cooling demands of buildings in urban areas. The fifth-generation district heating and cooling (5GDHC) concept, often referred to as ambient loops, is a novel solution emerging in Europe and has become a widely discussed topic in current energy system research. 5GDHC systems operate at a temperature close to the ground and include electrically driven heat pumps and associated thermal energy storage in a building-sited energy transfer station (ETS) to satisfy user comfort. This work presents new strategies for improving the operation of these energy transfer stations by means of a model predictive control (MPC) method based on recurrent artificial neural networks. The results show that, under simple time-of-use utility rates, the advanced controller outperforms a rule-based controller for smart charging of the domestic hot water (DHW) thermal energy storage under specific boundary conditions. By exploiting the available thermal energy storage capacity, the MPC controller is capable of shifting up to 14% of the electricity consumption of the ETS from on-peak to off-peak hours. Therefore, the advanced control implemented in 5GDHC networks promotes coupling between the thermal and the electric sector, producing flexibility on the electric grid.
Identifying Problems in Watering Ponds with Different Purposes
Authors: Pulido Manuel , Alfonso-Torreño Alberto , Barrena-González Jesús , Robina-Ramírez Rafael , Abdennour Mohamed Amine
Published: August 2020

The main goal of this study was to identify the problems that are putting the viability of watering ponds at risk. For doing that, we have analyzed five different study cases: (I) livestock consumption, Mediterranean climate (rangelands of SW Spain), (II) multifunctional ponds (Arroyo de la Luz, Spain), (III) ecotourism (Valdepajares de Tajo, Spain), (IV) crop irrigation and fish farming, semi-arid climate (the wilaya of Ouargla, Algeria), and (V) livestock consumption, humid subtropical climate (Prudentópolis, Brazil). The identification of problems was made through surveys, personal interviews, local knowledge and literature review as well as through the analysis of water quality parameters such as the concentration of phosphates and fecal coliforms in some ponds. We have identified problems of water shortage (ca. 50% of rangeland farmers), pollution induced by agriculture (maximum values of phosphates = 1.33 mg L−1) and livestock farming (maximum value of fecal coliforms ≈ 7000 cfu mL−1), low potability for human consumption (score: 2.8/7.0), invasive species such as Azolla filiculoides (10 out of 17 watering ponds), high water temperature for aquaculture in summer (Algeria) and the increase of turbidity in nearby water courses due to the actions of free-fattening pigs (Brazil), among many other problems. We conclude an extra effort by stakeholders is still needed in order to agree mitigation strategies.
Treatment of Polycyclic Aromatic Hydrocarbons in Oil Sands Process-Affected Water with a Surface Flow Treatment Wetland
Authors: Cancelli Alexander M. , Gobas Frank A. P. C.
Published: August 2020

This study applied a passive sampling approach using low-density polyethylene passive samplers to determine the treatment efficiency of the Kearl surface flow treatment wetland for polycyclic aromatic hydrocarbons (PAHs) in Oil Sands Process-affected Waters (OSPW). Treatment efficiency was measured as concentration-reduction and mass-removal from the OSPW. The results show that the wetland’s ability to remove individual PAHs from the influent varied substantially among the PAHs investigated. Treatment efficiencies of individual PAHs ranged between essentially 0% for certain methylated PAHs (e.g., 2,6-dimethylnaphthalene) to 95% for fluoranthene. Treatment in the Kearl wetland reduced the combined total mass of all detected PAHs by 54 to 83%. This corresponded to a reduction in the concentration of total PAHs in OSPW of 56 to 82% with inflow concentrations of total PAHs ranging from 7.5 to 19.4 ng/L. The concentration of pyrene in water fell below water quality targets in the Muskeg River Interim Management Framework as a result of wetland treatment. The application of the passive samplers for toxicity assessment showed that in this study PAHs in both the influent and effluent were not expected to cause acute toxicity. Passive sampling appeared to be a useful and cost-effective method for monitoring contaminants and for determining the treatment efficiency of contaminants in the treatment wetland.
Impacts of Forest Thinning on Wildland Fire Behavior
Authors: Banerjee Tirtha
Published: August 2020

Key message: We have explored the impacts of forest thinning on wildland fire behavior using a process based model. Simulating different degrees of thinning, we found out that forest thinning should be conducted cautiously as there could be a wide range of outcomes depending upon the post-thinning states of fuel availability, fuel connectivity, fuel moisture and micrometeorological features such as wind speed. Context: There are conflicting reports in the literature regarding the effectiveness of forest thinning. Some studies have found that thinning reduces fire severity, while some studies have found that thinning might lead to enhanced fire severity. Aims: Our goal was to evaluate if both of these outcomes are possible post thinning operations and what are the limiting conditions for post thinning fire behavior. Methods: We used a process based model to simulate different degrees of thinning systematically, under two different conditions, where the canopy fuel moisture was unchanged and when the canopy fuel moisture was also depleted post thinning. Both of these scenarios are reported in the literature. Results: We found out that a low degree of thinning can indeed increase fire intensity, especially if the canopy fuel moisture is low. A high degree of thinning was effective in reducing fire intensity. However, thinning also increased rate of spread under some conditions. Interestingly, both intensity and rate of spread were dependent on the competing effects of increased wind speed, fuel loading and canopy fuel moisture. Conclusion: We were able to find the limits of fire behavior post thinning and actual fire behavior is likely to be somewhere in the middle of the theoretical extremes explored in this work. The actual fire behavior post thinning should depend on the site specific conditions which would determine the outcome of the interplay among the aforementioned conditions. The work also highlights that policymakers should be careful about fine scale canopy architectural attributes and micrometeorological aspects when planning fuel treatment operations.
The Strength of the Nutrient Solution Modulates the Functional Profile of Hydroponically Grown Lettuce in a Genotype-Dependent Manner
Authors: Senizza Biancamaria , Zhang Leilei , Miras-Moreno Begoña , Righetti Laura , Zengin Gokhan , Ak Gunes , Bruni Renato , Lucini Luigi , Sifola Maria Isabella , El-Nakhel Christophe , Corrado Giandomenico , Rouphael Youssef
Published: August 2020

Considering that functional components of plant foods are mainly secondary-metabolism products, we investigated the shaping of health-promoting compounds in hydroponically grown butterhead lettuce (Lactuca sativa L. var. capitata) as a function of the strength of the nutrient solution utilized. To this aim, untargeted metabolomics profiling, in vitro antioxidant capacity (total phenolics, 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS), cupric reducing antioxidant capacity (CUPRAC), and ferric reducing antioxidant power (FRAP) assays), and the inhibition of selected enzyme activities were investigated in two butterhead lettuce cultivars with different pigmentation, i.e., green and red Salanova. Full-strength nutrition, together with half- and quarter-strength solutions of macronutrients, was tested. Our results indicate that by reducing the nutrients strength, we could elicit a distinctive shaping of the phenolic profile of lettuce. It is noteworthy that only specific classes of phenolics (namely, lignans and phenolic acids, followed by flavones and anthocyanins) were modulated by the induction of nutritional eustress (fold-change values in the range between −5 and +11). This indicates that specific responses, rather than a generalized induction of phenolic compounds, could be observed. Nonetheless, a genotype-dependent response could be observed, with the red cultivar being much more responsive to nutritional deprivation than the green Salanova lettuce. Indeed, analysis of variance (ANOVA) confirmed a genotype x nutrition interaction in red Salanova (p < 0.001). As a consequence of the changes in phenolic composition, also the antioxidant capacity (p < 0.001) and amylase inhibition (p < 0.001) properties were affected by the growing conditions. However, the effect on cholinesterase and tyrosinase inhibition was poorly affected by the nutritional strength. Provided that yields are not compromised, the application of a controlled nutritional eustress in hydroponically cultivated lettuce may represent a valuable strategy to produce food with tailored functional features in a sustainable manner.
Antioxidant, Antibacterial Activities and Mineral Content of Buffalo Yoghurt Fortified with Fenugreek and Moringa oleifera Seed Flours
Authors: Dhawi Faten , El-Beltagi Hossam S. , Aly Esmat , Hamed Ahmed M.
Published: August 2020

Recently, there is an increasing demand for functional yoghurts by consumer, especially those produced through the incorporation of food of plant origin or its bioactive components. The current research was devoted to formulating functional buffalo yoghurt through the addition of 0.1 and 0.2% of fenugreek (Trigonella foenum-graecum) seed flour (F1 and F2) and Moringa oleifera seed flour (M1 and M2). The effects of fortification were evaluated on physicochemical, total phenolic content (TPC), antioxidant activity (AOA), the viability of yoghurt starter, and sensory acceptability of yoghurts during cold storage. Moringa oleifera seed flour had higher contents of TPC (140.12 mg GAE/g) and AOA (31.30%) as compared to fenugreek seed flour (47.4 mg GAE/g and 19.1%, respectively). Values of TPC and AOA significantly increased in fortified yoghurts, and M2 treatment had the highest values of TPC (31.61, 27.29, and 25.69 mg GAE/g) and AOA (89.32, 83.5, and 80.35%) at 1, 7, and 14 days of storage, respectively. M2 showed significantly higher antibacterial activity against E. coli, S. aureus, L. monocytogenes, and Salmonella spp. and the zones of inhibition were 12.65, 13.14, 17.23 and 14.49 mm, respectively. On the other hand, control yoghurt showed the lowest antibacterial activity and the zones of inhibition were (4.12, 5.21, 8.55, and 8.39 mm against E. coli, S. aureus, L. monocytogenes, and Salmonella spp., respectively). Incorporation of 0.1% and 0.2% of moringa seed flour (M1 and M2) led to a higher content of Ca, P, K, and Fe and lower content of Mg and Zn as compared to F1 and F2, respectively. Thus, it could be concluded that fenugreek and Moringa oleifera seed flour can be exploited in the preparation of functional novel yoghurt.
Rapid HPLC Method for Determination of Isomaltulose in the Presence of Glucose, Sucrose, and Maltodextrins in Dietary Supplements
Authors: Crha Tomáš , Pazourek Jiří
Published: August 2020

This paper presents a rapid HPLC method for the separation of isomaltulose (also known as Palatinose) from other common edible carbohydrates such as sucrose, glucose, and maltodextrins, which are commonly present in food and dietary supplements. This method was applied to determine isomaltulose in selected food supplements for special diets and athletic performance. Due to the selectivity of the separation system, this method can also be used for rapid profiling analysis of mono-, di-, and oligosaccharides in food.
The Genetic Effect on Muscular Changes in an Older Population: A Follow-Up Study after One-Year Cessation of Structured Training
Authors: He Lingxiao , Van Roie Evelien , Bogaerts An , Verschueren Sabine , Delecluse Christophe , Morse Christopher I. , Thomis Martine
Published: August 2020

Older adults lose muscle mass and strength at different speeds after the cessation of physical exercise, which might be genotype related. This study aimed to explore the genetic association with changes in muscle mass and strength one year after the cessation of structured training in an older population. Participants (n = 113, aged between 61 and 81 years) who performed one-year of combined fitness (n = 44) or whole-body vibration (n = 69) training were assessed one year after the cessation of the training. Whole-body skeletal muscle mass and knee strength were measured. Data-driven genetic predisposition scores (GPSs) were calculated and analysed in a general linear model with sex, age, body mass index and post-training values of skeletal muscle mass or muscle strength as covariates. Forty-six single nucleotide polymorphisms (SNPs) from an initial 170 muscle-related SNPs were identified as being significantly linked to muscular changes after cessation. Data-driven GPSs and over time muscular changes were significantly related (p < 0.01). Participants with higher GPSs had less muscular declines during the cessation period while data-driven GPSs accounted for 26–37% of the phenotypic variances. Our findings indicate that the loss of training benefits in older adults is partially genotype related.
A Preliminary Study on the Characteristics of microRNAs in Ovarian Stroma and Follicles of Chuanzhong Black Goat during Estrus
Authors: Lu Tingting , Zou Xian , Liu Guangbin , Deng Ming , Sun Baoli , Guo Yongqing , Liu Dewu , Li Yaokun
Published: August 2020

microRNAs (miRNAs) play a significant role in ovarian follicular maturity, but miRNA expression patterns in ovarian stroma (OS), large follicles (LF), and small follicles (SF) have been rarely explored. We herein aimed to identify miRNAs, their target genes and signaling pathways, as well as their interaction networks in OS, LF, and SF of Chuanzhong black goats at the estrus phase using small RNA-sequencing. We found that the miRNA expression profiles of LF and SF were more similar than those of OS—32, 16, and 29 differentially expressed miRNAs were identified in OS vs. LF, OS vs. SF, and LF vs. SF, respectively. Analyses of functional enrichment and the miRNA-targeted gene interaction network suggested that miR-182 (SMC3), miR-122 (SGO1), and miR-206 (AURKA) were involved in ovarian organogenesis and hormone secretion by oocyte meiosis. Furthermore, miR-202-5p (EREG) and miR-485-3p (FLT3) were involved in follicular maturation through the MAPK signaling pathway, and miR-2404 (BMP7 and CDKN1C) played a key role in follicular development through the TGF-β signaling pathway and cell cycle; nevertheless, further research is warranted. To our knowledge, this is the first study to investigate miRNA expression patterns in OS, LF, and SF of Chuanzhong black goats during estrus. Our findings provide a theoretical basis to elucidate the role of miRNAs in follicular maturation. These key miRNAs might provide candidate biomarkers for the diagnosis of follicular maturation and will assist in developing new therapeutic targets for female goat infertility.
Specific Resistance of Barley to Powdery Mildew, Its Use and Beyond: A Concise Critical Review
Authors: Dreiseitl Antonín
Published: August 2020

Powdery mildew caused by the airborne ascomycete fungus Blumeria graminis f. sp. hordei (Bgh) is one of most common diseases of barley (Hordeum vulgare). This, as with many other plant pathogens, can be efficiently controlled by inexpensive and environmentally-friendly genetic resistance. General requirements for resistance to the pathogens are effectiveness and durability. Resistance of barley to Bgh has been studied intensively, and this review describes recent research and summarizes the specific resistance genes found in barley varieties since the last conspectus. Bgh is extraordinarily adaptable, and some commonly recommended strategies for using genetic resistance, including pyramiding of specific genes, may not be effective because they can only contribute to a limited extent to obtain sufficient resistance durability of widely-grown cultivars. In spring barley, breeding the nonspecific mlo gene is a valuable source of durable resistance. Pyramiding of nonspecific quantitative resistance genes or using introgressions derived from bulbous barley (Hordeum bulbosum) are promising ways for breeding future winter barley cultivars. The utilization of a wide spectrum of nonhost resistances can also be adopted once practical methods have been developed.
Screening of Virulence-Related Transcriptional Regulators in Streptococcus suis
Authors: Liu Liang , Zhang Qiang , Xu Zhongmin , Chen Bo , Zhang Anding , Sun Xiaomei , Jin Meilin
Published: August 2020

Streptococcus suis (S.suis) is an important zoonotic pathogen that causes many severe diseases in pigs and humans. Virulence-related transcriptional regulators have been widely reported in pathogenic microorganisms, but only a few have been identified in S.suis. Our aim was to screen virulence-related transcriptional regulators in S.suis. A total of 89 such genes were predicted in the S.suis genome, of which 22 were up-regulated and 18 were down-regulated during S.suis infection in mice. To evaluate the roles of these differentially expressed factors in S.suis virulence, deletion mutants were constructed, and 10 mutants were successfully obtained. Among these genes, the deletion of comR, sitR, or sxvR caused significantly decreased virulence in mice, compared to that with the wild-type strain. Moreover, the survival of ΔcomR, ΔsitR, and ΔsxvR mutant strains in blood was significantly reduced both in vitro and in vivo. Furthermore, their pro-inflammatory abilities were also obviously decreased in vivo. The regulatory mechanisms of comR, sitR, and sxvR were then analyzed by whole transcriptome RNA sequencing (RNA-Seq). Results indicated that the absence of comR induced the down-regulation of 17 virulence factors or virulence-related factors, including genes involved in the synthesis of capsules, oxidative stress tolerance, immune evasion, and cell division. Furthermore, three and two virulence factors or virulence-related factors were down-regulated upon deletion of sitR and sxvR, respectively. Thus, this study reports the discovery of three virulence-associated transcriptional regulatory factors in S.suis. These factors could ultimately be targeted to control infection caused by these bacteria.
Consequences of 22q11.2 Microdeletion on the Genome, Individual and Population Levels
Authors: Karbarz Małgorzata
Published: August 2020

Chromosomal 22q11.2 deletion syndrome (22q11.2DS) (ORPHA: 567) caused by microdeletion in chromosome 22 is the most common chromosomal microdeletion disorder in humans. Despite the same change on the genome level, like in the case of monozygotic twins, phenotypes are expressed differently in 22q11.2 deletion individuals. The rest of the genome, as well as epigenome and environmental factors, are not without influence on the variability of phenotypes. The penetrance seems to be more genotype specific than deleted locus specific. The transcript levels of deleted genes are not usually reduced by 50% as assumed due to haploinsufficiency. 22q11.2DS is often an undiagnosed condition, as each patient may have a different set out of 180 possible clinical manifestations. Diverse dysmorphic traits are present in patients from different ethnicities, which makes diagnosis even more difficult. 22q11.2 deletion syndrome serves as an example of a genetic syndrome that is not easy to manage at all stages: diagnosis, consulting and dealing with.
Novel Mutations in CLPP, LARS2, CDH23, and COL4A5 Identified in Familial Cases of Prelingual Hearing Loss
Authors: Zafar Saba , Shahzad Mohsin , Ishaq Rafaqat , Yousaf Ayesha , Shaikh Rehan S. , Akram Javed , Ahmed Zubair M. , Riazuddin Saima
Published: August 2020

We report the underlying genetic causes of prelingual hearing loss (HL) segregating in eight large consanguineous families, ascertained from the Punjab province of Pakistan. Exome sequencing followed by segregation analysis revealed seven potentially pathogenic variants, including four novel alleles c.257G>A, c.6083A>C, c.89A>G, and c.1249A>G of CLPP, CDH23, COL4A5, and LARS2, respectively. We also identified three previously reported HL-causing variants (c.4528C>T, c.35delG, and c.1219T>C) of MYO15A, GJB2, and TMPRSS3 segregating in four families. All identified variants were either absent or had very low frequencies in the control databases. Our in silico analyses and 3-dimensional (3D) molecular modeling support the deleterious impact of these variants on the encoded proteins. Variants identified in MYO15A, GJB2, TMPRSS3, and CDH23 were classified as “pathogenic” or “likely pathogenic”, while the variants in CLPP and LARS2 fall in the category of “uncertain significance” based on the American College of Medical Genetics and Genomics/Association for Molecular Pathology (ACMG/AMP) variant pathogenicity guidelines. This paper highlights the genetic diversity of hearing disorders in the Pakistani population and reports the identification of four novel mutations in four HL families.
Urban Engineered Slope Collapsed in Rome on February 14th, 2018: Results from Remote Sensing Monitoring
Authors: Bozzano Francesca , Esposito Carlo , Mazzanti Paolo , Innocca Federico , Romeo Saverio
Published: August 2020

On February 14th, 2018, in the North-Western sector of the Municipality of Rome (Central Italy), in the framework of an excavation for building construction, a portion of a piling wall piling wall collapsed in an already densely urbanized area. Soil behind the collapsed piling wall slipped inside the excavation site dragging seven cars parked on one side of the road running parallel to the piling wall and affecting some residential buildings located on the opposite side of the road. Fortunately, no injuries were counted but the 22 families living in the buildings next to the damaged wall were evacuated. Following the piling wall collapse, the Civil Protection of Rome, thanks to the technical support of the Research Centre on Geological Risks (CERI) of the Sapienza University of Rome, started a continuous monitoring of the affected area through remote sensing techniques. In the first hours following the collapse, a Terrestrial Synthetic Aperture Radar Interferometer (TInSAR) and a terrestrial laser scanner (TLS) were installed with the aim to control the evolution of the process, to support the local authority to manage the associated residual risk, and to ensure the safety of workers during emergency operations. In this paper we discuss some of the results obtained by the monitoring of the involved area. Thanks to the comparisons between different surveys and the reconstruction of the pre-event geometries, the total volume involved in the failure was estimated around 850 m3. In addition, through the analysis of data acquired by the 18 multi-temporal TLS scans and the three and a half months of continuous TInSAR monitoring, the movement involving a portion of the filling material used for stabilization works was observed and described. Such movement, reaching a total displacement of about 270–300 mm, was monitored and reported in real time.
Surface Geomorphological Features of Deep-Seated Gravitational Slope Deformations: A Look to the Role of Lithostructure (N Apennines, Italy)
Authors: Mariani Guido S. , Zerboni Andrea
Published: August 2020

The attention to deep-seated gravitational slope deformations (DSGSDs) has steadily increased in the last few decades, because such features are ubiquitous in mountain areas. Their geomorphological surface expression, especially when related to the effects of lithostructural control in sedimentary stratified bedrocks, is well characterized in theory, but sometimes not as well documented in field cases. In this contribution the investigation of several DSGSDs in the area of the Northern Apennines of Italy is reported. A survey of the area was conducted using fast and low-cost satellite imaging techniques, in order to describe the surface features of selected DSGSDs and verify how their occurrence is linked to the effect of lithostructural constrains such as bedding and folding. Surface features developed in parallel to the strike of the slope are mostly related to the main gravitative strain acting on the deformation. Features along slope dip are instead formed by the release of tension caused by compressive forces at the landslide foot or by the presence of pre-existing weak lines. One example of a DSGSD, formed on the hinge of a vertical fold, shows a corrugated appearance due to the release of vertical fractures that mask most other features usually associated with DSGSDs. This potentially impairs the detection of these landforms during field and remote surveys.
Intestinal Immune Homeostasis and Inflammatory Bowel Disease: A Perspective on Intracellular Response Mechanisms
Authors: Ranjan Kishu
Published: August 2020

The pathogenesis of inflammatory bowel disease (IBD) involves perturbation of intestinal immune homeostasis in genetically susceptible individuals. A mutual interplay between intestinal epithelial cells (IECs) and gut resident microbes maintains a homeostatic environment across the gut. An idiopathic gastrointestinal (GI) complication triggers aberrant physiological stress in the epithelium and peripheral myeloid cells, leading to a chronic inflammatory condition. Indeed, events in the endoplasmic reticulum (ER) and mitochondria contribute to orchestrating intracellular mechanisms such as the unfolded protein response (UPR) and oxidative stress, respectively, to resolve aberrant cellular stress. This review highlights the signaling cascades encrypted within ER and mitochondria in IECs and/or myeloid cells to dissipate chronic stress in maintaining intestinal homeostasis.
The Whale in the Cape Verde Islands: Seascapes as a Cultural Construction from the Viewpoint of History, Literature, Local Art and Heritage
Authors: Vieira Nina , Brito Cristina , Garcia Ana Catarina , Luz Hilarino da , Noronha Hermano , Pereira Dúnia
Published: August 2020

Cultural constructions of landscapes, space and environments, and of people’s relationship with nature, have in the Cape Verde Islands a perspective of their own and might have been mediated by the whale. To address perceptions about these marine mammals, historical sources, literature, art, memory and heritage were considered. Whaling influenced history and diaspora and is reflected in literary productions. Remains of whales are found in museums and used as decorative pieces and local art. We found the Cape Verdean seascapes as being culturally and naturally constructed and the whale occupies a true ‘place’ of convergence.
Developing Sustainable Classification of Diseases via Deep Learning and Semi-Supervised Learning
Authors: Yin Chunwu , Chen Zhanbo
Published: August 2020

Disease classification based on machine learning has become a crucial research topic in the fields of genetics and molecular biology. Generally, disease classification involves a supervised learning style; i.e., it requires a large number of labelled samples to achieve good classification performance. However, in the majority of the cases, labelled samples are hard to obtain, so the amount of training data are limited. However, many unclassified (unlabelled) sequences have been deposited in public databases, which may help the training procedure. This method is called semi-supervised learning and is very useful in many applications. Self-training can be implemented using high- to low-confidence samples to prevent noisy samples from affecting the robustness of semi-supervised learning in the training process. The deep forest method with the hyperparameter settings used in this paper can achieve excellent performance. Therefore, in this work, we propose a novel combined deep learning model and semi-supervised learning with self-training approach to improve the performance in disease classification, which utilizes unlabelled samples to update a mechanism designed to increase the number of high-confidence pseudo-labelled samples. The experimental results show that our proposed model can achieve good performance in disease classification and disease-causing gene identification.
Scabies and Pediculosis in Penitentiary Institutions in Poland—A Study of Ectoparasitoses in Confinement Conditions
Authors: Bartosik Katarzyna , Tytuła Andrzej , Zając Zbigniew , Buczek Weronika , Jasztal-Kniażuk Anita , Błaszkiewicz Paweł Szczepan , Borzęcki Adam
Published: August 2020

Background: Scabies (caused by Sarcoptes scabiei var. hominis) and pediculosis (caused by Pediculus humanus) are infectious diseases common in educational institutions and long-term care centres. The aim of the study was to assess the scale of the phenomenon in confinement conditions favouring the spread of these parasitoses. Methods: Data on the prevalence of scabies (2001–2015) and pediculosis (2008–2015) in Polish prisoners were provided by the Central Board of Prison Service. The information for the period between 2010 and 2015 in the Lublin Province was obtained from the District Inspectorate of the Prison Service in Lublin. Correlations between the prevalence of scabies and pediculosis and the number of prisoners were analysed, as well as correlations between the number of passes granted to prisoners and the prevalence of scabies and pediculosis in incarcerated individuals. Results: The prevalence of scabies and pediculosis in Polish prisoners has been estimated at 2.3% and 1.9%, respectively. Conclusions: Pediculosis and scabies are still current issues in Polish prisons. Convicts returning from passes and new prisoners should be carefully examined and monitored for the presence of S. scabiei var. hominis and P. humanus invasion. Education of prisoners could be a promising tool in prevention of scabies and pediculosis in correctional settings.
The Cost-Effectiveness of Hepatitis C Virus Screening Strategies among Recently Arrived Migrants in the Netherlands
Authors: Al Khayat Mohamed N.M.T. , Eijsink Job F.H. , Postma Maarten J. , Wilschut Jan C. , van Hulst Marinus
Published: August 2020

Objective: We aimed to assess the cost-effectiveness of hepatitis C virus (HCV) screening strategies among recently arrived migrants in the Netherlands. Methods: A Markov model was used to estimate the health effects and costs of HCV screening from the healthcare perspective. A cohort of 50,000 recently arrived migrants was used. In this cohort, three HCV screening strategies were evaluated: (i) no screening, (ii) screening of migrants from HCV-endemic countries and (iii) screening of all migrants. Results: Strategy (ii) screening of migrants from HCV-endemic countries compared to strategy (i) no screening, yielded an incremental cost-effectiveness ratio (ICER) of €971 per quality-adjusted life-years (QALYs) gained. Strategy (iii) screening of all migrants compared with strategy (ii) screening of migrants from HCV-endemic countries yielded an ICER of €1005 per QALY gained. The budget impact of strategy (ii) screening of migrants from HCV-endemic countries and strategy (iii) screening of all migrants was €13,752,039 and €20,786,683, respectively. Conclusion: HCV screening is cost-effective. However, the budget impact may have a strong influence on decision making.
Perceived Value Influencing the Household Waste Sorting Behaviors in Rural China
Authors: Ma Ying , Koondhar Mansoor Ahmed , Liu Shengke , Wang Huiling , Kong Rong
Published: August 2020

Waste sorting is the cardinal measurement to solve the problem of low efficiency of rural environmental governance and to alleviate environmental pollution by reduction, recycling, and harmlessness in rural areas. However, non-excludable and non-rival features of public goods easily cause a wide free-rider problem, which results in a low frequency of participation in the waste sorting of rural people. Based on the theory of the utility maximization of the rational economic man, this paper investigates survey data of 688 farm households in three cities and three counties of Shaanxi Province to explore the effect of the perceived value on the household waste classification behavior based on cost-benefit analysis. The results show that perceived benefit and perceived cost are important perceived value factors affecting farmers’ participation in waste sorting. Specifically, the spiritual benefit of the perceived benefit has a significantly positive impact on classification behavior, while the time cost, physical cost, and material cost of the perceived cost have a negative impact on waste classification behavior. Further study of the heterogeneity of income impact shows that time cost only has a significant impact on the high-income group of farmers’ classification behavior, while spiritual benefit and learning cost only affect the low-income group of farmers’ waste classification behavior. Material cost has different influence directions on high- and low-income groups. In view of the aforementioned findings, this study highlights corresponding policy implications from the perspective of perceived benefit and perceived cost.
Empirical Relationships between Problematic Alcohol Use and a Problematic Use of Video Games, Social Media and the Internet and Their Associations to Mental Health in Adolescence
Authors: Wartberg Lutz , Kammerl Rudolf
Published: August 2020

Adolescents frequently show risky behavior, and these problematic behavior patterns often do not occur in isolation, but together. Problematic alcohol use is widespread among youth, as is problematic use of the Internet and of specific online applications (video games or social media). However, there is still a lack of findings for minors regarding the relations between these behavioral patterns (particularly between problematic alcohol use and problematic gaming or problematic social media use). Standardized instruments were used to survey problematic alcohol use, problematic gaming, problematic social media use, problematic Internet use and mental health among 633 adolescents (mean age: 15.79 years). Bivariate correlation and multivariable linear regression analyses were conducted. The correlation analyses showed statistically significant positive bivariate relationships between all four behavioral patterns each. Antisocial behavior was related to all problematic behavioral patterns. Whereas, emotional distress, self-esteem problems and hyperactivity/inattention were associated with substance-unrelated problematic behavior patterns only. Anger control problems were related to problematic alcohol use and problematic gaming. In adolescence, the findings revealed small effect sizes between substance-related and substance-unrelated problematic behavior patterns, but moderate to large effect sizes within substance-unrelated behavioral patterns. Similarities and differences were found in the relations between the behavioral patterns and mental health.
Adherence to the Mediterranean Diet and Environmental Impact of the Diet on Primary School Children Living in Parma (Italy)
Authors: Rosi Alice , Biasini Beatrice , Donati Michele , Ricci Cristian , Scazzina Francesca
Published: August 2020

The key role of diet in both human health and environmental sustainability is well known. However, there is a lack of studies investigating the environmental impact of children’s dietary behavior. The aim of this observational study was to investigate the dietary environmental impact in a sample of primary school children living in Parma (Italy, n = 172, 8–10 years), in relation to their adherence to the Mediterranean diet (MD). Children completed a 3-day food record in both winter and spring. Dietary records were processed to obtain: (i) adherence to the MD and (ii) mean daily carbon and ecological footprints. Adherence to the MD was similar in winter and spring, with almost half of the participants showing a medium MD score. Carbon and ecological footprints were higher during winter, and the main dietary contributors were red and processed meat for both indexes. A small positive correlation was observed between adherence to the MD and total carbon and ecological footprints. This study provided the first analysis of the relationship between adherence to the MD and environmental impact of primary school children. Further research is needed to better investigate the environmental impact of primary school children’s diet and the possible relationship between the MD and environmental sustainability.
Rapid Review of SARS-CoV-1 and SARS-CoV-2 Viability, Susceptibility to Treatment, and the Disinfection and Reuse of PPE, Particularly Filtering Facepiece Respirators
Authors: Derraik José G. B. , Anderson William A. , Connelly Elizabeth A. , Anderson Yvonne C.
Published: August 2020

In the COVID-19 pandemic caused by SARS-CoV-2, hospitals are often stretched beyond capacity. There are widespread reports of dwindling supplies of personal protective equipment (PPE), particularly N95-type filtering facepiece respirators (FFRs), which are paramount to protect frontline medical/nursing staff, and to minimize further spread of the virus. We carried out a rapid review to summarize the existing literature on the viability of SARS-CoV-2, the efficacy of key potential disinfection procedures against the virus (specifically ultraviolet light and heat), and the impact of these procedures on FFR performance, material integrity, and/or fit. In light of the recent discovery of SARS-CoV-2 and limited associated research, our review also focused on the closely related SARS-CoV-1. We propose a possible whole-of-PPE disinfection solution for potential reuse that could be rapidly instituted in many health care settings, without significant investments in equipment.
Case Study in a Working Environment Highlighting the Divergence between Sound Level and Workers’ Perception towards Noise
Authors: Hon Chun-Yip , Tchernikov Illia , Fairclough Craig , Behar Alberto
Published: August 2020

Excessive noise levels are a prevalent issue in food processing operations and, although there have been numerous studies on occupational noise, no single study has used a concurrent mixed-methods approach. Employing this study design allows for an understanding of the level of convergence (similarity) between measured noise levels and workers’ attitudes and perceptions towards noise. This, in turn, allows for the identification of potential challenges with respect to the implementation of hearing conservation efforts. In this study, spot noise measurements were collected using a sound level meter. One-on-one interviews were conducted with workers to determine attitudes and perceptions towards noise in their workplaces. Subsequently, the results of the noise measurements (quantitative data) were integrated with the survey responses (qualitative data) to identify convergence. The majority of the noise measurements were found to exceed 85 dBA—the criterion mandated by the local occupational health and safety legislation. Although all study participants felt that it was noisy in the workplace, a large proportion of respondents indicated that the noise was not bothersome. With workers’ perception being contradictory to the measured noise levels, it is a challenge to implement hearing conservation measures unless changes are made to raise the awareness of the risks associated with excessive noise exposure.
Impact of the Built Environment and the Neighborhood in Promoting the Physical Activity and the Healthy Aging in Older People: An Umbrella Review
Authors: Bonaccorsi Guglielmo , Manzi Federico , Del Riccio Marco , Setola Nicoletta , Naldi Eletta , Milani Chiara , Giorgetti Duccio , Dellisanti Claudia , Lorini Chiara
Published: August 2020

(1) Background: The aim of this study is to establish which specific elements of the built environment can contribute to improving the physical activity of self-sufficient, noninstitutionalized and living in the city adults > 65 years. (2) Methods: An extensive literature search was conducted in several database. Umbrella review methodology was used to include the reviews that presented a sufficient methodological quality. (3) Results: Eleven reviews were included. The elements positively associated with physical activity in older adults were: walkability; residential density/urbanization; street connectivity; land-use mix-destination diversity; overall access to facilities, destinations and services; pedestrian-friendly infrastructures; greenery and aesthetically pleasing scenery; high environmental quality; street lighting; crime-related safety; traffic-related safety. The elements that were negatively associated with physical activity were: poor pedestrian access to shopping centers; poor pedestrian-friendly infrastructure and footpath quality; barriers to walking/cycling; lack of aesthetically pleasing scenery; crime-related unsafety; unattended dogs; inadequate street lighting and upkeep; traffic; littering, vandalism, decay; pollution; noise. (4) Conclusions: Evidence shows that specific elements of the built environment can contribute to promoting older people’s physical activity. The city restructuring plans should take into consideration these factors.
Unplanned Absenteeism: The Role of Workplace and Non-Workplace Stressors
Authors: Mat Saruan Nur Adibah , Mohd Yusoff Hanizah , Mohd Fauzi Mohd Fadhli , Wan Puteh Sharifa Ezat , Muhamad Robat Rosnawati
Published: August 2020

Unplanned absenteeism (UA), which includes medically certified leave (MC) or emergency leave (EL), among nurses may disturb the work performance of their team and disrupt the quality of patient care. Currently, there is limited study in Malaysia that examines the role of stressors in determining absenteeism among nurses. Therefore, apart from estimating the prevalence and the reasons of UA among nurses in Malaysia, this study aims to determine its stressor-related determinants. A cross-sectional study was conducted among 697 randomly sampled nurses working in Selangor, Malaysia. Most of them were female (97.3%), married (83.4%), and working in shifts (64.4%) in hospital settings (64.3%). In the past year, the prevalence of ever taking MC and EL were 49.1% and 48.4%, respectively. The mean frequency of MC and EL were 1.80 (SD = 1.593) and 1.92 (SD = 1.272) times, respectively. Meanwhile, the mean duration of MC and EL were 4.24 (SD = 10.355) and 2.39 (SD = 1.966) days, respectively. The most common reason for MC and EL was unspecified fever (39.2%) and child sickness (51.9%), respectively. The stressor-related determinants of durations of MC were inadequate preparation at the workplace (Adj.b = −1.065) and conflict with doctors (adjusted regression coefficient (Adj.b) = 0.491). On the other hand, the stressor-related determinants of durations of EL were conflict with spouse (Adj.b = 0.536), sexual conflict (Adj.b = −0.435), no babysitter (Adj.b = 0.440), inadequate preparation at workplace (Adj.b = 0.257), lack of staff support (Adj.b = −0.190) and conflict with doctors (Adj.b = −0.112). The stressor-related determinants of the frequency of MC were conflicts over household tasks (Adj.b = −0.261), no time with family (Adj.b = 0.257), dangerous surroundings (Adj.b = 0.734), conflict with close friends (Adj.b = −0.467), and death and dying (Adj.b = 0.051). In contrast, the stressor-related determinants of frequency of EL were not enough money (Adj.b = −0.334), conflicts with spouse (Adj.b = 0.383), pressure from relatives (Adj.b = 0.207), and inadequate preparation (Adj.b = 0.090). In conclusion, apart from the considerably high prevalence of unplanned absenteeism and its varying frequency, duration and reasons, there is no clear distinction in the role between workplace and non-workplace stressors in determining MC or EL among nurses in Malaysia; thus, preventive measures that target both type of stressors are warranted. Future studies should consider longitudinal design and mixed-method approaches using a comprehensive model of absenteeism.
Acute Myocardial Infarction among Young Adult Men in a Region with Warm Climate: Clinical Characteristics and Seasonal Distribution
Authors: Shih Chiao-Yu , Chu Min-Liang , Hsieh Tsung-Cheng , Chen Han-Lin , Lee Chih-Wei
Published: August 2020

The aim of this cross sectional study was to investigate the influence of the seasons on acute myocardial infarction (AMI) among young adult among young adults aged <45 years compared to old adults aged ≥45 years. The seasonal distribution of AMI hospital admissions among young adult men in eastern Taiwan was assessed. Data were extracted from 1413 male AMI patients from January 1994 to December 2015, including onset date, the average temperature (Tave) on the date of AMI hospitalization (AMI-Tave), and conventional risk factors, notably smoking, diabetes, hypertension, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, and body mass index (BMI). The 1413 cases were divided into two groups: the young group (n = 138, <45 y/o) and the older group (n = 1275, ≥45 y/o). The differences between groups were examined. Logistic regression analyses were used to evaluate the associations between the seasons and the AMI hospitalization among the young group. The young group showed significantly higher percentage of smokers, BMI, total cholesterol levels, and triglycerides levels but lower percentage of diabetes and hypertension than the older group (p < 0.05). AMI hospitalization in winter was significantly greater compared to the other seasons among the young group (p < 0.05). Winter hospitalization was significantly associated with the young group relative to the older group (adjusted OR 1.750; 95% CI 1.151 to 2.259), while winter AMI-Tave in the young group was similar to that in the older group. Young adult men diagnosed with AMI are more likely than older adult men to be smokers, obese, and show an onset dependent on winter but not low-temperature in a region with a warm climate.