bluuebunny/crossref_metadata_2025 huggingface dataset:
High-Density Lipoprotein Subfractions Remodeling: A Critical Process for the Treatment of Atherosclerotic Cardiovascular Diseases
Authors: Zhang Yaling , Luo Shiyu , Gao Yi , Tong Wenjuan , Sun Shaowei
Published: February 2023

Numerous studies have shown that a low level of high-density lipoprotein cholesterol (HDL-C) is an independent biomarker of cardiovascular disease. High-density lipoprotein (HDL) is considered to be a protective factor for atherosclerosis (AS). Therefore, raising HDL-C has been widely recognized as a promising strategy to treat atherosclerotic cardiovascular diseases (ASCVD). However, several studies have found that increasing HDL-C levels does not necessarily reduce the risk of ASCVD. HDL particles are highly heterogeneous in structure, composition, and biological function. Moreover, HDL particles from atherosclerotic patients exhibit impaired anti-atherogenic functions and these dysfunctional HDL particles might even promote ASCVD. This makes it uncertain that HDL-raising therapy will prevent and treat ASCVD. It is necessary to comprehensively analyze the structure and function of HDL subfractions. We review current advances related to HDL subfractions remodeling and highlight how current lipid-modifying drugs such as niacin, statins, fibrates, and cholesteryl ester transfer protein inhibitors regulate cholesterol concentration of HDL and specific HDL subfractions.
Tobacco Smoke Exposure and Gastrointestinal Problems Among US Children
Authors: Merianos Ashley L. , Mahabee-Gittens E. Melinda
Published: February 2023

This study examined the association between home tobacco smoke exposure (TSE) status and gastrointestinal problems in the past 12 months among US children. We conducted a secondary analysis of the 2018-2019 National Survey of Children’s Health cross-sectional data including 20 149 children aged 4 to 10 years. Weighted logistic regression models unadjusted and adjusted for child and family covariates were fitted. Overall, 12.3% of children had home thirdhand smoke (THS) exposure only and 1.8% had home secondhand smoke (SHS) and THS exposure. Unadjusted (odds ratio [OR] = 1.70, 95% confidence interval [CI] = 1.32-2.20) and adjusted (adjusted odds ratio [AOR] = 1.51, 95% CI = 1.14-1.99) logistic regression results indicated that relative to children with no home TSE, children with home THS exposure only were at increased odds of having frequent or chronic difficulty with gastrointestinal problems over the past 12 months. Interventions are critically needed to promote smoking cessation among household members who live with children in order to reduce levels of SHS and THS in their homes.
Use of Intravenous Anakinra for Management of Pediatric Cytokine Storm Syndromes at an Academic Medical Center
Authors: Yang Lirong , Lowry Sandra , Heath Travis
Published: February 2023

Background: Off-label intravenous (IV) route of anakinra is increasingly recognized to enable higher and faster maximal plasma concentrations than subcutaneous route for treatment of cytokine storm syndromes. Objective: To describe off-label indications of IV anakinra, corresponding dosing and safety profiles, particularly during the coronavirus disease 19 (COVID-19) pandemic. Methods: A retrospective, single-cohort study was conducted at an academic medical center to evaluate use of IV anakinra in hospitalized pediatric patients (age ≤21 years). Institutional Review Board review was considered exempt. The primary endpoint was the primary indication(s) for IV anakinra. The key secondary endpoints were dosing of IV anakinra, previous immunomodulatory therapies, and adverse events. Results: Of 14 pediatric patients, 8 (57.1%) received IV anakinra for treatment of multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19, whereas 3 and 2 were treated for hemophagocytic lymphohistiocytosis (HLH) and flares of systemic onset juvenile idiopathic arthritis (SoJIA), respectively. The initial dosing regimen of IV anakinra for MIS-C associated with COVID-19 was a median dose of 2.25 mg/kg/dose with a median dosing interval of 12 hours for a median initial treatment duration of 3.5 days. Eleven (78.6%) patients received previous immunomodulatory therapies (IV immune globulin [n = 10; 71.4%] and steroids [n = 9; 64.3%]). No adverse drug events were documented. Conclusion: IV anakinra was used off-label for treatment of MIS-C associated with COVID-19, HLH and SoJIA flares in critically ill patients with no adverse drug events documented. This study helped ascertain the off-label indications of IV anakinra and corresponding patient characteristics.
Materiovigilance in Intensive Care Units: An Active Surveillance
Authors: Attri Lakshay Kumar , Subhash Chandra Ballaekere Jayaram , Ramesh Madhan , Chalasani Sri Harsha , Syed Jehath , Pal Nikita
Published: February 2023

Background: Medical devices are the vital part of healthcare system. The use of medical devices is higher in the intensive care units leading to increased exposure rendering the exponential rise in incidence of medical device associated adverse events (MDAEs). Timely detection and reporting of MDAEs can help reduce the disease and associated liabilities. Objective: To determine the rate, patterns, and predictors of MDAEs. Methods: An active surveillance was carried out in the intensive care units (ICUs) of a tertiary care teaching hospital located in southern India. The patients were monitored for MDAEs which were reported based on MvPI guidance document 1.2. The predictors were calculated using an odds ratio at 95% confidence interval. Results: A total of 185 MDAEs were reported amongst 116 patients, of which the majority [74 (63.7%)] were males. Most of the MDAEs were attributed to urethral-catheters [42 (22.7%)] among which a high majority of 34 were associated with urinary tract infections (UTI), followed by ventilators [35 (18.9%)] with all events causing pneumonia. Urethral catheters and ventilators are both classified as categories B and C respectively based on device risk classification provided by the Indian Pharmacopoeia Commission (IPC). Over 58% of MDAEs were reported among the elderly. The causality assessment was possible for 90 (48.6%) MDAEs whereas 86 (46.4%) were probable. The majority of the MDAEs reported were serious [165 (89.2%)] and only [20 (10.8%)] were found to be non-serious on the severity scale. Most [104 (56.2%)] of the devices attributed to MDAEs were single-use devices, of which [103 (55.6%)] were destroyed and only [81 (43.7%)] were retained in healthcare facilities. Conclusions: Despite the best possible care in the intensive care units (ICUs), MDAEs are inevitable, adding to the burden of patients in terms of suffering, disease, extended hospital stay, and increased costs. MDAEs require rigorous monitoring of patients, especially in the elderly population and patients with increased exposure to multiple devices.
Structural Inequity and Socioeconomic Status Link to Osteoporosis Diagnosis in a Population-Based Cohort of Middle-Older-Age Americans
Authors: Gough Courtney Margaret , Roberts Josephine , Godde Kanya
Published: February 2023

Socioeconomic status (SES) is an important social determinant of health inequities that has been linked to chronic conditions, including osteoporosis, but research tends to focus on socioeconomic disadvantage rather than how socioeconomic advantage may facilitate these inequities. This study accounts for structural inequities and assesses the relationship between early-life and later-life SES, and risk of osteoporosis diagnosis. Data come from the nationally representative, population-based cohort Health and Retirement Study and include individuals ages 50 to 90. The outcome variable is osteoporosis diagnosis. Logistic regression models of the relationship between SES and osteoporosis diagnosis are estimated, accounting for demographic, health, and childhood variables. Higher levels of childhood and adult SES link to lower odds of osteoporosis diagnosis. Structural inequities in income and underdiagnosis of osteoporosis among persons identifying as Black/African American were detected. Accounting for bone density scan access, inequities in osteoporosis diagnosis appear to stem from barriers to accessing health care due to financial constraints. The important role of SES and evidence of structural inequities leading to underdiagnosis suggest the critical importance of clinicians receiving Diversity, Equity, and Inclusion training to reduce health inequities.
Studies on thermoset blend of bismaleimide having multiple swivel groups and biscyanate ester
Authors: J Dhanalakshmi , S Siva Kaylasa Sundari , S Sivaprakash , Vijayakumar CT
Published: February 2023

The materials 2,2-bis [4-(4-maleimidophenoxy phenyl)] propane (BMIX) and bisphenol-A based cyanate ester (BCY) were synthesized. The monomers BMIX and BCY were physically blended (BMCY) in 1:1 mol ratio. The materials BMIX, BCY and BMCY were thermally polymerized and the structural characterisation of the materials was done using Fourier transform infrared spectrophotometer (FTIR). The curing characteristics of BMIX, BCY and its blend (BMCY) were investigated using differential scanning calorimeter (DSC). The blend BMCY shows considerable differences in the thermal curing behaviour as evidenced by the DSC studies. Blending BCY with BMIX drastically reduces the melting temperature, curing onset temperature and the amount of heat liberated during thermal curing. The thermal stabilities of the crosslinked network polymers (PBMIX, PBCY and PBMCY) were investigated using thermogravimetric analyser (TGA). Detailed TGA studies indicated that the PBMCY shows better thermal stability than the PBMIX and PBCY. The DSC and TG curves indirectly hint about the possible reaction between BMIX and BCY during thermal curing. Woven glass fibre reinforced laminates were prepared using BMIX, BCY and BMCY by solution impregnation followed by drying and compression moulding. The glass laminate having BMCY as the matrix resin showed much better mechanical property (tensile strength) compared to the laminate made using BMIX as the matrix resin.
Over a third of palliative medicine physicians meet burnout criteria: Results from a survey study during the COVID-19 pandemic
Authors: Boland Jason W , Kabir Monisha , Spilg Edward G , Webber Colleen , Bush Shirley H , Murtagh Fliss , Lawlor Peter G
Published: February 2023

Background:

Palliative medicine physicians may be at higher risk of burnout due to increased stressors and compromised resilience during the COVID-19 pandemic. Burnout prevalence and factors influencing this among UK and Irish palliative medicine physicians is unknown.

Aim:

To determine the prevalence of burnout and the degree of resilience among UK and Irish palliative medicine physicians during the COVID-19 pandemic, and associated factors.

Design:

Online survey using validated assessment scales assessed burnout and resilience: The Maslach Burnout Inventory Human Services Survey for Medical Personnel [MBI-HSS (MP)] and the Connor-Davidson Resilience Scale (CD-RISC). Additional tools assessed depressive symptoms, alcohol use, and quality of life.

Setting/participants:

Association of Palliative Medicine of UK and Ireland members actively practising in hospital, hospice or community settings.

Results:

There were 544 respondents from the 815 eligible participants (66.8%), 462 provided complete MBI-HSS (MP) data and were analysed. Of those 181/462 (39.2%) met burnout criteria, based on high emotional exhaustion or depersonalisation subscales of the MBI-HSS (MP). A reduced odds of burnout was observed among physicians who worked ⩽20 h/week (vs 31–40 h/week, adjusted odds ratio (aOR) 0.03, 95% confidence interval (CI) 0.002–0.56) and who had a greater perceived level of clinical support (aOR 0.70, 95% CI 0.62–0.80). Physicians with higher levels of depressive symptoms had higher odds of burnout (aOR 18.32, 95% CI 6.75–49.73). Resilience, mean (SD) CD-RISC score, was lower in physicians who met burnout criteria compared to those who did not (62.6 (11.1) vs 70.0 (11.3); p < 0.001).

Conclusions:

Over one-third of palliative medicine physicians meet burnout criteria. The provision of enhanced organisational and colleague support is paramount in both the current and future pandemics.
Channeling the capital of others: How Luxembourg came to be asset managers’ “plumber” of choice
Authors: Weeks Samuel
Published: February 2023

This article analyzes the development and growth of the administrative practices and structures necessary for leading asset management companies and other firms to create and sell their “product” of choice: investment funds. To investigate this problematic, I turn to the Grand Duchy of Luxembourg, which currently serves as the domicile for over $5 trillion in fund assets. Since the 1980s, Luxembourg's “offshore” financial center has become a leader in providing the “plumbing,” to quote an interviewee of mine, for worldwide asset manager capitalism. On offer in Luxembourg to asset managers are the routine-but-essential tasks such as domiciliation, compliance, calculation of net-asset values, and distributions. After a brief history of the rise of asset manager capitalism and Luxembourg's role in it, I detail the strategies by which the Grand Duchy's financial-center professionals collaborate to devise ways to service the ever-increasing varieties of investment funds for sale today. Having used the Luxembourg financial center as a case study, I conclude the article by arguing that, in order to understand contemporary asset manager capitalism, researchers should pay as much attention to its “collaborating administrators” in locales like Luxembourg as they currently do to its “competing titans of industry” on Wall Street or in the City of London.
The Associations Between Quadriceps Tendon Graft Thickness and Isokinetic Performance
Authors: Letter Michael I. , Parrino Rosalia L. , Adams Will , Ripic Zachary , Baraga Michael G. , Kaplan Lee D. , Harrah Tanner , Tremblay Julien , Luxenburg Dylan , Conti Joseph , Signorile Joseph F.
Published: February 2023

Background:

Anterior cruciate ligament reconstruction (ACLR) using the quadriceps tendon is an increasingly popular technique. Both partial-thickness quadriceps tendon (PT-Q) and full-thickness quadriceps tendon (FT-Q) graft depths are employed.

Hypothesis/Purpose:

This study was designed to assess isokinetic peak torque, average power, and total work during knee extension in patients with FT-Q or PT-Q grafts for ACLR. We hypothesized that both groups would show lower isokinetic values for the operated side, with greater deficits in the FT-Q group than in the PT-Q group.

Study Design:

Cohort study; Level of evidence, 3.

Methods:

A total of 26 patients who underwent ACLR with either an FT-Q or PT-Q graft were recruited between June 2021 and November 2021. Patients underwent isokinetic knee extension testing at > 1 year after surgery. Mixed repeated-measures analysis of covariance with least square difference post hoc testing was used to determine significant differences or interactions for all variables.

Results:

Peak torque was significantly lower for the operated limb than the nonoperated limb in the FT-Q group (mean difference [MD] ± standard error [SE], −38.6 ± 8.3 Nċm [95% CI, −55.7 to −21.5 Nċm]; P < .001; d = 0.90) but not in the PT-Q group (MD ± SE, −7.3 ± 7.7 Nċm [95% CI, −23.2 to 8.5 Nċm]; P = .348; d = 0.20). Similarly, average power for the operated limb was lower than that for the nonoperated limb in the FT-Q group (MD ± SE, −53.6 ± 13.4 W [95% CI, −81.3 to −26.9 W]; P < .001; d = 0.88) but not in the PT-Q group (MD ± SE, –4.1 ± 12.4 W [95% CI, −29.8 to 21.5 W]; P = .742; d = 0.07), and total work was lower for the operated limb compared with the nonoperated limb in the FT-Q group (MD ± SE, −118.2 ± 27.1 J [95% CI, −174.3 to −62.2 J]; P < .001; d = 0.96) but not in the PT-Q group (MD ± SE, −18.3 ± 25.1 J [95% CI, −70.2 to 33.6 J]; P = .472; d = 0.15).

Conclusion:

The FT-Q group showed significant deficits in the operated limb compared with the nonoperated limb for all isokinetic variables. In contrast, no significant differences were found between the nonoperated and operated limbs for the PT-Q group.
Diagnostic Accuracy of Conventional Ankle CT Scan With External Rotation and Dorsiflexion in Patients With Acute Isolated Syndesmotic Instability
Authors: Rodrigues João Carlos , do Amaral e Castro Adham , Rosemberg Laercio Alberto , de Cesar Netto Cesar , Godoy-Santos Alexandre Leme
Published: February 2023

Background:

Syndesmotic injury in an athletic population is associated with a prolonged ankle disability after an ankle sprain and often requires a longer recovery than a lateral collateral ligament injury. Although several imaging tests are available, diagnosing syndesmotic instability remains challenging.

Purpose:

To determine the diagnostic accuracy of conventional ankle computed tomography (CT) scans with the joint in external rotation and dorsiflexion and compare it with that of conventional ankle CT scans in a neutral position.

Study Design:

Cohort study (Diagnosis); Level of evidence, 2.

Methods:

Between September 2018 and April 2021, this prospective study consecutively included adults visiting the foot and ankle outpatient clinic with a positive orthopaedic examination for acute syndesmotic injury. Participants underwent 3 CT scan tests. First, ankles were scanned in a neutral position. Second, ankles were scanned with 45° of external rotation, dorsiflexion, and extended knees. Third, ankles were scanned with 45° of external rotation, dorsiflexion, and flexed knees. Three measurements, comprising rotation (measurement a), lateral translation (measurement c), and anteroposterior translation (measurement f) of the fibula concerning the tibia, were used to diagnose syndesmotic instability in the 3 CT scans. Magnetic resonance imaging was used as a reference standard. The area under the curve (AUC) was used to compare the diagnostic accuracy, and Youden’s J index was calculated to determine the ideal cutoff point.

Results:

Images obtained in 68 participants (mean age, 36.5 years; range, 18-69 years) were analyzed, comprising 36 syndesmotic injuries and 32 lateral collateral ligament injuries. The best diagnostic accuracy occurred with the rotational measurement a, in which the second and third CT scans with stress maneuvers presented greater AUCs (0.97 and 0.99) than did the first CT scan in a neutral position (0.62). The ideal cutoff point for the stress maneuvers was 1.0 mm in the rotational measurement a and reached a sensitivity and specificity of 83% and 97% for the second CT scan with extended knees and 86% and 100% for the third CT scan with flexed knees, respectively. The ideal cutoff point for the first CT scan with a neutral position was 0.7 mm in the rotational measurement a, with a sensitivity of 25% and specificity of 97%.

Conclusion:

Conventional ankle CT with stress maneuvers has excellent performance for diagnosing subtle syndesmotic rotational instability, as it shows a greater AUC and enhanced sensitivity at the ideal cutoff point compared with ankle CT in the neutral position.
Disentangling Social Class–based Inequality: How Social Position Affects Evaluations of Economic and Cultural Markers of Social Class
Authors: Nichols Bethany J.
Published: February 2023

How do the economic and cultural components of social class separately contribute to social class–based inequality? I argue that one approach to disentangle the effects of economic and cultural markers is to consider how decision-makers’ own social positions influence their evaluations of others in micro-level processes. I posit that decision-makers’ social positions influence their understandings and evaluations of the economic and cultural components of social class, giving rise to bias and inequality. In a series of original survey experiments, I manipulate the economic and cultural markers of a fictitious college applicant on subjects with elite and nonelite university degrees. The results show that the markers of social class affect individuals with elite degrees and individuals without elite degrees differently. I find that it is the cultural markers of social class, not the economic markers, that affect the judgments of evaluators with elite degrees. Applicants’ perceived competence and status help to explain the positive effect of cultural markers on evaluators with elite degrees. These results show the importance of social position and micro-level evaluation processes to help explain social class–based inequality.
“No Free Homeland Without Free Women:” Tal’at's Indigenous Feminist Movement
Authors: Saba Jessica
Published: February 2023

On September 3, 2019, Israa Ghrayeb, a 21-year-old woman was murdered by her family. Soon after, on September 26, 2019, thousands of protestors took to the streets throughout 12 cities including Jerusalem, Ramallah, Rafah, and Haifa. The protests were organized by the Indigenous Palestinian feminist movement, Tal’at. Tal’at is translated literally from Arabic as “stepping out” and is semantically translated as “rising up.” It's slogan “No Free Homeland without Free Women” encapsulates the movement's assertion that national liberation and feminist liberation must be fought together. The femicide of Israa Ghrayeb mobilized Palestinian feminists to call for an end to gender-based violence, for legal accountability, and collective liberation. Palestinian women are faced with the intersecting oppression of both Palestinian patriarchal norms as well the Zionist military occupation and apartheid system. This paper examines the emergence and influence of Tal’at and its concurrent resistance to patriarchy and Zionist settler colonialism. It is ultimately a call to action for feminist social workers to act in solidarity with Tal’at's struggle for feminist, queer, and national justice and liberation.
Intergenerational Transmission of Child Abuse Among Married Women in South Korea: A Multigroup Analysis of Empathetic Communication (TSL: Thanks, Sorry, and Love)
Authors: Choi Sunah , Kim Jae Yop , Kim Eunkyung , Oh Sehun
Published: February 2023

Intergenerational transmission of child abuse (hereinafter referred to as ITCA) has been continuously reported. Supportive relations with others have also been discussed as a protective factor to prevent this cycle. However, research has mainly investigated supportive adult and peer relationships formed in childhood, with little discussion of the impact of supportive partner relationships formed after becoming an adult. This study examined whether empathetic communication (hereinafter referred to as TSL: “Thanks, Sorry, and Love”) attenuates the transmission of married women’s child abuse experiences to subsequent generations mediated by intimate partner violence (hereinafter referred to as IPV). TSL is a communication strategy that promotes positive communication between intimate partners. We expected TSL to promote positive communication between couples through a process of self-transformation. Data from 1,122 married women were obtained from a nation-wide survey conducted in South Korea. All the survey respondents lived with partners and their own children simultaneously. For this study, structural equation model multigroup analysis was conducted to determine whether the pathways would be attenuated by TSL levels, showing that a high level of TSL communication attenuated the ITCA mediated by IPV. However, this process was maintained in the low-level TSL group. TSL is thus a protective factor against the ITCA. The findings suggest that healing processes can occur not only through childhood relationships but also through those formed after adulthood. Ultimately, to help victims recover, it is necessary to expand communication programs such as TSL that help victims learn how to express their feelings through healthy relationships with their partners.
“I Know Myself Again, Which Makes Me Motivated for Life”: Feasibility and Acceptability of Using Experience Sampling Methods With Trauma-Exposed Sexual Minority Women
Authors: Scheer Jillian R. , Cascalheira Cory J. , Helminen Emily C. , Shaw Thomas J. , Schwarz Aubriana A. , Jaipuriar Virinca , Brisbin Cal D. , Batchelder Abigail W. , Sullivan Tami P. , Jackson Skyler D.
Published: February 2023

Intensive longitudinal designs (e.g., experience sampling methods [ESMs]) hold promise for examining the dynamic interplay between daily adversity, coping strategies, and behavioral and mental health issues among marginalized populations. However, few studies have used intensive longitudinal designs with sexual minority women (SMW), an understudied and at-risk population. We assessed feasibility and acceptability of using once-daily, interval-contingent ESM with 161 trauma-exposed SMW ( Mage = 29.1, SD = 7.57); 20.5% nonbinary; 32.3% queer; 52.2% people of color; 14.3% with annual incomes ≤$9,999; and 30.4% in Southern United States (U.S.). SMW completed one comprehensive online baseline assessment and once-daily brief online assessments for 14 days. Daily surveys assessed past-24-hour stressors, stress responses, and behavioral and mental health symptoms. At the end of the 14-day ESM period, SMW answered three open-ended questions about participating in this study and about research with SMW. Regarding feasibility, 151 participants (94.0%) initiated the post-baseline ESM study portion and 72 (45.0%) completed all 14 daily surveys. An average of 11.70 (median = 13, SD = 3.31) daily surveys (83.5%) were completed by those who initiated the ESM. ESM completion level varied by race/ethnicity and U.S. region. Qualitative acceptability data revealed several themes, namely that SMW (1) enjoyed participating and felt positively about the ESM experience, (2) felt supported to reflect on impacts of early and ongoing stressors, (3) appreciated the chance to self-reflect and challenge existing thought patterns and coping behaviors, (4) recognized their capacity to tolerate trauma-related distress, (5) recommended that researchers focus on SMW’s diverse stressors and daily experiences, (6) wanted a rationale for providing sensitive information and more space to narrate their experiences, and (7) recognized the need for affirmative treatment and policies. Findings could inform modifications to ESM protocols to improve their feasibility and acceptability among trauma-exposed SMW and promote ongoing utility of this valuable method.
Understanding Economic Development Organization Efforts to Advance Inclusive Economic Recovery in Virginia
Authors: Cowell Margaret , Haskins Conaway , Sayed Shaheera
Published: February 2023

This research incorporates preliminary findings from a survey and case studies of economic development organizations (EDOs) in Virginia as these entities initiate their economic recovery planning processes in the post-COVID-19 pandemic era. The research seeks to understand the extent to which EDOs understand—and engage in conversations about—racial and economic inclusion in the context of economic recovery and to learn more about the strategies being deployed to promote inclusive recovery in the post-COVID era. Though some common characteristics were identified, the results demonstrate significant variation in both the extent to which inclusivity is prioritized and how it is conceived of in recovery planning efforts. The findings suggest that while many economic development organizations are signaling a commitment to inclusivity, albeit, in assorted ways, there remains a need for further dialogue about how inclusivity is defined and how it can best translate into actionable strategies.
Influence of construction method of submicron polybutadiene particles on transparent methacrylate-acrylonitrile-butadiene-styrene resin properties
Authors: Xu Lu , Tang Qianyi , Hu Yiwei , Liu Baijun , Zhang Mingyao
Published: February 2023

Submicron polybutadiene particles were prepared using four different methods: one-step batch emulsion polymerization, pressure agglomeration, acid agglomeration, and polymer latex agglomeration. Core-shell elastomers were synthesized by grafting styrene and methyl methacrylate on polybutadiene particles. Transparent methacrylate-acrylonitrile-butadiene-styrene resin was prepared by blending the elastomers with methacrylate-styrene-acrylonitrile matrix resin synthesized by bulk polymerization. The effects of the construction method of submicron rubber particles on core-shell elastomer structure and composite properties were investigated. Additionally, the relationship between the rubber phase structure and composite properties was studied. The obtained results showed that the construction method significantly affected the size distribution and morphology of the submicron rubber particles. The rubber particles prepared by one-step batch emulsion polymerization were grafted easily, with 90.2% grafting efficiency of the corresponding core-shell elastomer. The grafting efficiency of the rubber particles prepared by acid agglomeration was only 69.4%. The former was most suitable as the toughening core of transparent Acrylonitrile-butadiene-styrene resin, and the transmittance and haze values of the composite were 90% and 2.4, respectively. Impact and tensile strengths were 185.6 J/m and 39 MPa, respectively. The acid agglomeration method generated submicron rubber particles more quickly, and the transmittance and haze of composite were 90% and 2.9, respectively. However, the impact and tensile strengths were reduced to 170.4 J/m and 31 MPa, respectively.
Linking Career Adaptability and Psychological Well-Being: A Test of Moderated Mediation Model Among Indian Employees
Authors: Nakra Neelam , Kashyap Vaneet
Published: February 2023

The present study attempts to investigate how career adaptability predicts psychological well-being (PWB) among employees based on career construction theory (CCT). Precisely, the study examined the role of career sustainability as a mediator and sustainable career climate (SCC) as a moderator establishing the relationship between career adaptability and psychological well-being. Data collected from 550 Indian employees in the Indian banking and IT organizations indicate that career adaptability has a significant effect on career sustainability that eventually predicts PWB. In addition, the findings on the interaction effect of career adaptability and SCC on PWB via career sustainability highlighted the significance of unison between individual and contextual factors in realizing important employee outcomes. The results revealed that the indirect effect of career adaptability on PWB through career sustainability is stronger among employees who perceived their organizational career climate to be sustainable.
A resource-based analysis of strategic alliances between knowledge intermediaries in regional innovation support systems
Authors: Bäumle Philipp , Bizer Kilian
Published: February 2023

Notwithstanding a recent upsurge in interest in knowledge intermediaries and their roles in innovation support systems, we know little about the interplay between the activities of academia-driven intermediaries and their publicly financed counterparts. Building on a combination of principles derived from the resource-based theory and entrepreneurial ecosystems literature, this paper investigates the potentials of cooperation between different knowledge intermediaries. Therefore, the authors analyze the alignment of financial, knowledge, market and network resources in politically funded regional alliances between university-internal and university-external intermediaries by means of a qualitative approach. They find that, while knowledge intermediaries can benefit from access to additional ecosystem-specific resources, the urge to improve their own position within the ecosystem hampers the will to cooperate and can lead to non-performing resource alignments. The paper contributes to current scholarly discussions by suggesting and testing a theoretical foundation for analyzing the cooperative behavior of knowledge intermediaries in innovation support systems.
Sensitivity analysis of a double-parallelogram based RCM mechanism used for MIS robots
Authors: Singh Amanpreet , Khatait Jitendra P
Published: February 2023

Parallelogram-based remote center-of-motion (RCM) mechanisms are extensively used to design robots for minimally invasive surgery (MIS). For their kinematic modeling, classically, it is assumed that link parameters of the opposite sides of constituting parallelograms are equal which made the RCM an invariant point and simplified the prescribed modeling process. However, link parameter equality does not exist in actual practice due to the inevitable constraints of manufacturing, assembly and testing/measurement, etc. Consequently, the RCM and surgical end-effector deviate from their theoretically designed positions. This paper introduces a novel approach to model the kinematics of parallelogram-based mechanisms by accounting for the error in manufactured link parameters. Additionally, it works out the types, possible ways, order, and nature of the said deviation. Further, a double-parallelogram-based RCM mechanism is adopted to demonstrate the proposed concept, and a prototype of the same is manufactured using laser micromachining and rapid prototyping techniques. Thereafter, the developed kinematic models are validated both analytically and physically. In contrast to the results given by the conventional kinematic modeling approach, the results obtained through the proposed approach and performed experiment showed better agreement with each other. The sensitivity of RCM and surgical end-effector to the inequalities, involved in the manufactured prototype, is revealed through several plots in the Matlab environment. A significant improvement in positional accuracy of the RCM and surgical end-effector have been achieved. It proves the efficacy of the presented method and it is believed that it applies to other parallelogram-based mechanisms as well.
Design considerations and simulation of a rolling-contact gearless automotive differential
Authors: Provatidis Christopher G. , Kalligeros Christos , Spitas Vasilios
Published: February 2023

This paper presents the design considerations, the kinematical simulation and the FE analysis of a differential mechanism which involves the rolling contact of two cam-track disks with four equally-spaced spherical rollers sliding in a cage much resembling a rolling bearing. The obvious benefit of this concept in the field of power transmissions is the potential replacement of gears in planetary reducers and differentials by cams. The side gears of a conventional open differential are replaced by two identical cam-track disks, while the spider gears are replaced by rolling elements that is, balls, cylinders or tapered cylinders. Practically, the well-known rolling bearing concept is generalized, where the circular tracks are replaced by wavy curves. In order to assess the performance of the mechanism, the shape of the tracks is considered for two distinct cases and a rigorous mathematical modeling follows regarding the kinematics of the mechanism. The results were validated through kinematical simulations and FE analysis was carried out coupled with fatigue life computation for a typical passenger vehicle differential, indicating that service life in the order of 200,000 km is feasible.
Nonlinear static and dynamic (deflection/stress) responses of porous functionally graded shell panel and experimental validation
Authors: Ramteke Prashik Malhari , Panda Subrata Kumar
Published: February 2023

The static and dynamic characteristics of functionally graded (FG) structures have been investigated in this article, considering full geometrical nonlinearity. The finite element (FE) solutions are obtained for the graded panel by modelling through higher-order kinematics (HSDT) and Green-Lagrange strain-displacement relations (GLNST). The desired graded panel properties are obtained through Voigt’s micromechanical approach, considering different grading patterns (exponential, EPL; sigmoid, SGM and power law, POL). Additionally, to maintain the generality of the graded structure, different porosity distribution types (even and uneven, EVP and UEP) are incorporated into the proposed mathematical model. Further, the numerical solutions are obtained using Newmark’s method’s direct iterative technique and constant integration steps. The solution sensitivities are verified for the developed algorithm via adequate convergence and comparison tests. In addition, the experimental validation is performed using the layerwise fabricated luffa-fibre reinforced FG plates to validate the proposed theoretical model’s accuracy. Lastly, the responses are computed using the newly derived model for the variable design-dependent parameters associated with the FG structural geometry and properties. The final deliverables, that is the nonlinear deflection responses (NDFR)/stress values, are discussed under mechanical loadings (static and dynamic).
Dynamic relationship between resource endowment, financial agglomeration, innovation-driven, and green total factor productivity
Authors: Li Xiangxue , Li Xingwei , Zhu Xiaowen , Huang Yicheng , Liu Xiang , Deng Wendan
Published: February 2023

As conflicts between emissions reductions and economic growth intensify, an increasing number of countries and regions are focusing on green total factor productivity (GTFP). Financial agglomeration (QWS), resource endowment (SE), and innovation-driven (ID) are the main factors that cause regional differences in GTFP. However, few scholars have comprehensively considered the impact of the interaction between SE, ID, and QWS on GTFP. This article uses the Global Malmquist-Luenberger (GML) index to calculate the GTFP of 30 Chinese provinces from 2003 to 2020 and constructs a dynamic panel model to present the first comprehensive study of the interactions between SE, ID, and QWS and their relationship with GTFP. The conclusions are as follows. (1) SE is positively correlated with GTFP, which is different from the “resource curse” theory proposed by existing research. (2) There is a crowding-out effect between SE and ID, and their interaction will restrain the growth of GTFP. (3) QWS promotes ID, and the interaction between the two promotes the growth of GTFP. (4) There is a restraining effect between QWS and SE, and their interaction will hinder the growth of GTFP. (5) The key policy directions to improve China's GTFP are to undertake strategic planning from a comprehensive perspective, including encouraging innovation, guiding financial development reasonably, and avoiding excessive consumption of resources.
State and unknown input set-valued estimation for uncertain linear discrete-time systems
Authors: Meslem Nacim , Hably Ahmad , Raïssi Tarek
Published: February 2023

Set-valued algorithms are designed in this work to compute rigorous bounds of the unknown inputs of uncertain discrete-time linear systems. First, based on the classical full-order and reduced-order unknown input observers, non-conservative numerical schemes are proposed to characterize the reachable set of the estimation error. Then, by using these results, set-membership estimators of the unknown inputs are presented. Moreover, the results of these estimators can be merged together via set-intersection operators to obtain more accurate estimates.
Reducing weekly working hours: Temporal strategies and changes in the organization and experiences of work-Results from a qualitative study of a 30-hour workweek experiment
Authors: Mullens Francisca , Glorieux Ignace
Published: February 2023

In 2019, Femma Wereldvrouwen, a Belgian women’s organization experimented with a 30-hour workweek on organizational level. All full-time employees reduced their weekly working hours from 36, 34, or 32 (depending on their age) to 30. The experiment lasted one calendar year. By integrating a sociological temporal lens and considering the different levels in the organization, this study investigates how the organization has adapted their work to a shorter workweek based on 20 in-depth interviews and 4 focus-group interviews with employees. We find that Femma Wereldvrouwen combined structural changes on organizational and team level in a formalized way, with room for individual employees to find their own new temporal strategies in a shorter workweek. These strategies relate to focused work and consciousness of time. Although this combined responsibility of making a shorter workweek work was fairly successful, Femma Wereldvrouwen also faced some challenges, such as the lack of “fun” interaction through breaks, and time for “white space” in work.
Logistic regression with correlated measurement error and misclassification in covariates
Authors: Cao Zhiqiang , Wong Man Yu , Cheng Garvin HL
Published: February 2023

Many areas of research, such as nutritional epidemiology, may encounter measurement errors of continuous covariates and misclassification of categorical variables when modeling. It is well known that ignoring measurement errors or misclassification can lead to biased results. But most research has focused on solving these two problems separately. Addressing both measurement error and misclassification simultaneously in a single analysis is less actively studied. In this article, we propose a new correction method for a logistic regression to handle correlated error variables involved in multivariate continuous covariates and misclassification in a categorical variable simultaneously. It is not computationally intensive since a closed-form of the approximate likelihood function conditional on observed covariates is derived. The asymptotic normality of this proposed estimator is established under regularity conditions and its finite-sample performance is empirically examined by simulation studies. We apply this new estimation method to handle measurement error in some nutrients of interest and misclassification of a categorical variable named physical activity in the European Prospective Investigation into Cancer and Nutrition-InterAct Study data. Analyses show that fruit is negatively associated with type 2 diabetes for a group of women doing active physical activity, protein has positive association with type 2 diabetes for the group of less active physical activity, and actual physical activity has a greater effect on reducing the risk of type 2 diabetes than observed physical activity.
Effect of acupuncture on brain functional networks in patients with mild cognitive impairment: an activation likelihood estimation meta-analysis
Authors: Xia Rui , Ren Jinxin , Wang Mengyang , Wan Yiwen , Dai Yalan , Li Xingjie , Wu Zhuguo , Chen Shangjie
Published: February 2023

Background:

Prior research has shown that acupuncture, a traditional Chinese medical therapy, may have a certain therapeutic effect in patients with mild cognitive impairment (MCI). Furthermore, some studies have explored the effects of acupuncture on the brain functional networks of MCI patients to investigate the mechanism of action. Different studies have analysed the brain regions involved in acupuncture-induced changes, but (to our knowledge) these have not been summarized by a systematic review.

Methods:

We searched PubMed, EMBASE, Cochrane Library, SinoMed, CNKI and other databases in Chinese and English to identify neuroimaging studies of acupuncture interventions in MCI patients. After two stages of literature screening, bias risk assessment and data extraction, brain regions with significant differences were input into GingerALE software. Based on the activation likelihood estimation algorithm, coordinate-based meta-analyses were conducted.

Results:

The changes in functional activation of 95 different areas in 8 trials, including 212 MCI patients, were analysed. The three most commonly used traditional acupuncture point locations in acupuncture interventions for MCI were KI3 ( Taixi), LR3 ( Taichong) and LI4 ( Hegu). The results of the ALE data analysis showed that, after acupuncture intervention, the degree of activation in the anterior cingulate, inferior frontal gyrus, medial frontal gyrus and cerebellar tonsil of MCI patients increased significantly.

Conclusions:

Acupuncture intervention for MCI appears to change the plasticity of brain function and improve the cognitive function of patients. Due to the small number and low quality of the included studies, the conclusion of this meta-analysis should be treated with caution.

Registration:

PROSPERO reference CRD42022301056 ( http://www.crd.york.ac.uk/PROSPERO ).
Camouflage: A dominant reaction to worsening conditions
Authors: Frey Bruno S
Published: February 2023

Individuals choose camouflage as a dominant response when a state’s political conditions worsen, particularly when a democracy turns authoritarian. Individuals hide their private preferences to survive under oppressive regimes. This paper argues that in many circumstances camouflage is the most rational, cost-minimizing reaction to oppression. The paper identifies five kinds of costs that induce individuals to resort to four different ideal types of camouflage: (1) avoidance of contact, (2) minimal participation, (3) restricted cooperation, and (4) full engagement with the oppressive regime. Camouflage is particularly advantageous as the costs of exit or voice are often high. Therefore, a large majority of citizens disagreeing with the ideology and policies of a regime are likely to camouflage.
Exploring Five Wishes and End-of-Life Care Planning in Young Adults
Authors: Stone Arianna , Perre Taylor , Young Yuchi
Published: February 2023

Introduction

Our study aims to (1) examine the perspectives of young adults toward Five Wishes, and (2) measure their preferences related to personal, emotional, spiritual, and medical choices in end-of-life care planning.

Methods

Data were collected using a structured survey questionnaire and Five Wishes. Participants include graduate students (n = 30) attending a university in New York State. Bivariate summary statistics were performed to address the study aims.

Results

The average age of the participants was 24 years old; 60% were female, 60% White, and 27% Black. In the case of permanent and severe brain damage without the expectation to wake up or recover, 63% of the participants do not want life-support treatment. In the event of a coma without expectation to wake up or recover, 53% do not want life-support treatment. When close to death, 80% want to have religious or spiritual readings and well-loved - poems read aloud.

Conclusion

Young adults are capable of making their own decisions about appointing a health care proxy and making choices for their personal, emotional, spiritual, and medical care for the future. The present findings intend to make contributions to the research pertaining to end-of-life care that promotes population-based healthcare decision-making, education, and awareness among young adults.
Experiences of Facilitators and Inhibitors to Treatment Adherence in Patients with Heart Failure
Authors: Gheiasi Seyede Fatemeh , Cheraghi Mohammad Ali , Dastjerdi Mahdieh , Navid Hossein , Khoshavi Meysam , Peyrovi Hamid , Khachian Alice , Seylani Khatereh , Esmaeili Maryam , Navab Elham
Published: February 2023

Treatment adherence is a fundamental aspect of heart failure (HF) management. This study aimed to explore the experiences of facilitators and inhibitors of treatment adherence in patients with HF. This descriptive qualitative study was conducted from May 2020 to June 2021. Participants including people with HF, their family caregivers and physicians, and nurses were selected purposefully, with the aim of obtaining sufficient information power. Semi-structured interviews were used to collect data. Data were analyzed using thematic analysis. Two main themes “the driving forces behind treatment adherence” and “the deterrent forces behind treatment adherence” emerged from the analysis. The first theme contained the following subthemes: “supportive family,” “positive personality characteristics,” and “having health literacy.” The second theme consisted of “negligence,” “psychological problems,” “cultural, social, and economic problems,” “physical limitations,” and “lack of self-care management knowledge.” Nurses can consider facilitators and inhibitors of treatment adherence in designing educational and care programs for patients with HF.