bluuebunny/crossref_metadata_2025 huggingface dataset:
MUSEOS E IDENTIDADES VISUALES DINÁMICAS. MECANISMOS DE LAS MARCAS GRÁFICAS COMO VEHÍCULO DE TRANSMISIÓN CULTURAL
Authors: BERTOLA GARBELLINI ANDREA , Martín-Ramallal, Pablo
Published: May 2022

Las identidades visuales evolucionan para adaptarse a nuevos formatos y soportes tecnológicos. Sus formas de comunicar han evolucionado, abandonando las estructuras estables e invariables del segundo milenio para convertirse en herramientas versátiles y expresivas. Las marcas se hacen dinámicas y flexibles, vectoriales y adaptativas. Los logos se convierten en manifestación de los cambios de patrones y de los medios comunicativos, respondiendo a las exigencias de expresar diversidad. Las instituciones culturales  encuentran en esta tendencia la respuesta a sus requisitos de comunicar sus variados contenidos a través de dispositivos móviles y de proponer de forma virtual su identidad visual de marca sin perder atractivo. Los espacios museísticos son proclives a esta tipología de la identidad visual corporativa (IVC), capaz de abarcar los cambios de estructura y de temas que estos ofrecen por naturaleza. Desde hace décadas los museos han ido adoptando masivamente logos líquidos, marcas visuales flexibles y adaptativas. Las crecientes exigencias de expresividad y de comunicación multiplataforma se conjugan, gracias a estas estructuras metamórficas, con sus propias ambiciones de juego y diversión visual.

El estudio se justifica debido al creciente auge de las identidades visuales dinámicas (IVCD), vinculadas a la evolución tecnológica y a la consecuente transformación de los hábitos de consumo de productos culturales; pretende además generar un mayor conocimiento de los principios en los que se rige su funcionamiento. Se comportan según reglas que les permite mantener sus inapelables características de visibilidad y originalidad que les garantizan pregnancia y consenso. Sus connotaciones acercan los públicos a procesos lúdicos propensos a la didáctica y a su involucración en las imperantes estrategias enfocadas a las narrativas transmedia. Analizamos cómo las identidades visuales de espacios museísticos actúan ejemplarmente en connotaciones artísticas. Se escoge entre una muestra de marcas gráficas de museos internacionales para ofrecer una taxonomía de su funcionamiento contemporáneo.
“El Mejunje”: artes, diversidad e inclusión en Santa Clara (Cuba).
Authors: Massó-Guijarro Belén
Published: May 2022

Ramón Silverio (1948, Santa Clara) es un dramaturgo, actor y director teatral cubano distinguido con las condecoraciones más importantes de su país (Distinción por la Cultura Nacional, Premio Ser Fiel, Diploma Nicolás Guillén de la Uneac, Premio Nacional de Cultura Comunitaria). Desde 1984  dirige el centro cultural “El Mejunje”, ubicado en Santa Clara, una experiencia única y pionera en el país de inclusión de comunidades marginadas (principalmente, LGTBI) a través de las artes. El centro cuenta con una programación semanal que incluye cine, teatro, trova cubana, rock y salsa, y desde sus inicios viene realizando una vital contribución a la habitabilidad de Santa Clara (García, 2020). También cuenta con un grupo de teatro con repertorio propio dirigido por Silverio, y organiza la Brigada “Los Colines”, en la que diversos artistas se desplazan para acercar el arte a la población de zonas rurales con dificultades de acceso a la cultura. Celebramos esta entrevista el 25 de noviembre de 2021 en el patio de “El Mejunje”, como parte del trabajo de campo que realicé en Cuba durante mi estancia de investigación en la Facultad de Ciencias Sociales (FLASCO-Cuba), tras la asistencia a un espectáculo de “Zona Rosa”, el proyecto de transformismo impulsado desde El Mejunje en una zona rural cercana a Santa Clara.
Liderança humanizada
Authors: Andrade Ana Paula Cavalcante Luna , Torres Maria de Fatima Nóbrega
Published: May 2022

O conceito de líder organizacional vem sofrendo mudanças nas últimas décadas exigindo dessa categoria esforço para entender os novos anseios das pessoas a ele subordinadas. Antes valorizados pelas suas competências técnicas, os líderes de hoje são chamados a apresentar um comportamento mais voltado para o cuidado com as pessoas e menos com o produto. A Universidade Católica possui uma missão humanística que pode motivar os alunos que vão exercer cargos de liderança para o desenvolvimento de um modo de agir, sustentado em princípios e valores, capaz de transformar as pessoas e as organizações. Diante desse cenário, esse estudo tem como objetivo analisar como essa instituição, através da sua missão, pode se fazer presente na formação dessas formas de liderança. Trata-se de mostrar uma nova perspectiva sobre a missão da Universidade Católica apresentando-a como possível formadora de líderes humanizados e refletindo sobre as consequências para as organizações de se praticar uma liderança dessa natureza atualmente.
A palavra de Deus aos cativos
Authors: Cavalcante Ronaldo de Paula
Published: May 2022

O genial teólogo Karl Barth, que com seu comentário à Carta aos Romanos, significou uma “guinada” na história da teologia, respondendo, com rigor intelectual e acadêmico ao pensamento liberal protestante, já incrédulo de elementos fundamentais da fé cristã, possuía igualmente a sua face pastoral que nunca foi abandonada. Após duas experiências paroquiais no início do século, na Suíça; nas décadas de 1950 e 1960, em 28 oportunidades, esteve na Instituição penal de Basel, pregando aos que ali estavam presos. Assim, no presente texto apresentamos uma síntese de sua trajetória acadêmica e pastoral e recuperamos alguns desses sermões, praticamente desconhecidos do público brasileiro. O engajamento pastoral de Barth tanto nas questões sociais e políticas, em especial no período da ascensão nazista, quanto sua presença no presídio, sinalizam uma pontual dimensão pública de seu ministério.
W L-shell X-ray emission induced by C6+ ions with several hundred MeV/u
Authors: Zhou Xian-Ming , Wei Jing , Cheng Rui , Mei Ce-Xiang , Zeng Li-Xia , Wang Xing , Liang Chang-Hui , Zhao Yong-Tao , Zhang Xiao-An ,   Ion beam and Optical Physics Laboratory, Xianyang Normal University, Xianyang 712000, China,   Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China,   School of Science, Xi’an Jiaotong University, Xi’an 710049, China
Published: May 2022

The L-shell X-ray emission of tungsten is investigated under the bombardment of C6+ ions in a high energy range of 154—424 MeV/u. Compared with the atomic data, the energy of the X-ray is enlarged, and the relative intensity ratio of Lι, Lβ1,3,4 and Lβ2,15 to Lα1,2 X-rays are enhanced. The L-subshell and the total X-ray production cross section are calculated from a well corrected thick target formula and compared with the theoretical estimation of binary encounter approximation (BEA), plane-wave Born approximation (PWBA) and ECPSSR (PWBA theory modified with Energy-loss, Coulomb-repulsion, Perturbed-Stationary-State and Relativistic corrections). On the whole, the experimental cross sections are all smaller than the prediction of PWBA and ECPSSR, but in rough agreement with that of BEA. It is indicated that the inner-shell ionization of W can be considered as a binary process between the high energy C6+ ions acting as a point charge and the independent target electrons. With the L-shell ionization, the outer-shells are multiply ionized. The multi-ionization degree is approximately regard as a constant in the present work. This leads the X-ray energy to be blueshifted and the relative intensity ratios of Lι and Lβ to Lα X-ray to be enhanced. Using the atomic parameters corrected by multi-ionization, the X-ray production cross section can be estimated by the BEA model.
Memristive brain-like computing
Authors: Wen Xin-Yu , Wang Ya-Sai , He Yu-Hui , Miao Xiang-Shui ,   Institute of Information Storage Materials and Devices, School of Integrated Circuits, Huazhong University of Science and Technology, Wuhan 430074, China,   Hubei Yangtze Memory Laboratories, Wuhan 430205, China
Published: May 2022

With the rapid development of deep learning, the current rapid update and iteration of intelligent algorithms put forward high requirements for hardware computing power. Limited by the exhaustion of Moore’s law and the von Neumann bottleneck, the traditional CMOS integration cannot meet the urgent needs of hardware computing power improvement. The utilization of new device memristors to construct a neuromorphic computing system can realize the integration of storage and computing, and has the characteristics of extremely high parallelism and ultra-low power consumption. In this work, the device structure and physical mechanism of mainstream memristors are reviewed in bottom-to-top order firstly, and their performance characteristics are compared and analyzed. Then, the recent research progress of memristors to realize artificial neurons and artificial synapses is introduced, including the simulation of specific circuit forms and neuromorphic functions. Secondly, in this work, the structural forms of passive and active memristive arrays and their applications in neuromorphic computing, including neural network-based handwritten digits and face recognition, are reviewed. Lastly, the current challenges of memristive brain-like computing from the bottom to the top, are summarized and the future development of this field is also prospected.
МЕТОДЫ ПОЗНАНИЯ: ОТ ПЕЧАТИ К СИГИЛЛОГРАФИИ, "Средние века"
Authors: Бедос-Резак Б. , Михальчук А.А. , Филиппов И.С.
Published: May 2022

В центре внимания автора вопрос о том, как на протяжении XVII в. у антикваров и историков-эрудитов сформировался интерес к печатям как к историческому источнику. В статье показано, как средневековые печати, долгое время привлекавшие внимание в основном специалистов по генеалогии и геральдики, в XVII в. постепенно стали самостоятельным предметом исследования, во всяком случае в Англии, Фландрии и Италии. Во Франции интерес к печатям возник несколько позднее и был связан с выходом в свет в 1681 г. трактата «De Re Diplomatica» Жана Мабильона. Центральное место в нем занимала проблема определения подлинности исторических документов. Эту проблему Мабильон предложил решать, опираясь на разные источники, в том числе и на данные печатей. Тем самым французский историк применил новый подход к изучению печатей, отодвинув на второй план их культурное и символическое значение и подчинив сигиллографию нуждам дипломатики. Автор полагает, что, несмотря на значение труда Мабильона для развития исторической науки и его интерес к печати как к источнику сведений о времени и обстоятельствах создания документа, его метод не стал основой разностороннего изучения печати как исторического источника. Истоки сигиллографии как комплексной дисциплины следует искать скорее в исследованиях, проводившихся в XVII в. в Англии, Фландрии и Италии.
АНТИКРИЗИСНАЯ ВАКЦИНА: ЗАЧЕМ МЕДИЕВИСТЫ ПЕРЕВОДЯТ И ПУБЛИКУЮТ СВОИ ИСТОЧНИКИ (ЗАМЕТКИ НА ПОЛЯХ ЧИТАТЕЛЬСКОЙ КОНФЕРЕНЦИИ ЖУРНАЛА «СРЕДНИЕ ВЕКА»), "Средние века"
Authors: Сидоров А.И.
Published: May 2022

В статье рассматривается проблема изменения статуса перевода средневековых источников и отношения к переводческой деятельности в отечественной медиевистике за последние двести лет. На протяжении XIX и большей части ХХ столетия российские историки, за редким исключением, не рассматривали подготовку комментированного перевода и его последующую публикацию в качестве самостоятельного и самоценного вида научной деятельности, отдавая эту сферу на откуп филологам и лингвистам. Ситуация резко изменилась на рубеже XX и XXI вв., что, очевидно, следует связать с резкой трансформацией самой исторической науки. В условиях разрушения научных методологий, усиливающейся фрагментации исторического знания и быстрой девальвации исследовательских наработок работа над переводом объективно оказалась для историков наиболее комфортной формой академической активности. С другой стороны, именно такой научный продукт сегодня востребован в полной мере у массовой аудитории.
ГЕКСАМИЛИОН И ПРОБЛЕМА ЗАЩИТЫ ПЕЛОПОННЕСА ОТ ТУРОК В ВИЗАНТИЙСКОЙ ПОЛИТИКЕ КОНЦА XIV – ПЕРВОЙ ПОЛОВИНЫ XV ВЕКА, "Средние века"
Authors: Рязанов П.А.
Published: May 2022

C конца XIV в. угроза турецкого завоевания нависла над Пелопоннесом. Правительство Морейского деспотата первым осознало необходимость возрождения Гексамилиона, позднеантичной стены, построенной поперек Истмийского перешейка для защиты от варваров. С этого времени византийская дипломатия включает вопрос восстановления истмийских укреплений в повестку дня. Ограниченные ресурсы деспотата поначалу не позволяли реализовать этот замысел собственными силами, поэтому Феодор I Палеолог был вынужден искать союза с Венецианской республикой и орденом госпитальеров. Только после масштабных восстановительных работ на перешейке, проведенных сначала Мануилом II Палеологом, а затем его сыном Константином XI, истмийские укрепления приобрели серьезный военно-оборонительный потенциал. Изучение проблемы защиты Истма в византийской политике конца XIV — первой половины XV в. и составляет цель данного исследования.
Effect of Aqueous Extract of Moringa oleifera Leaves on Some Serum Enzymes of Wistar Rats with Carbon Tetrachloride-Induced Liver Damage
Authors: Omeodu S. I. , Eruotor H. O. , Akpan M. U.
Published: May 2022

Introduction: The study was aimed at evaluating the hepatoprotective effect of Moringa oleifera leaf extract against liver damage induced by carbon tetrachloride (CCl4).

Methods: 25 Wistar rats were used. They were administered orally with CCl4 in a ratio of 1:1 at a dose of 1500mg/kg and allowed for five days before treated with Moringa oleifera leaf extract at concentrations of 50mg/kg, 100mg/kg, and 150mg/kg daily for one week. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma glutamyl transferase (GGT), and total protein (TP) in the blood cells were determined. The study lasted for 18 days. The liver enzyme, ALT, and TP were increased after injection with CCl4.

Results: Treatment with Moringa oleifera leave at various dose reveals a significant reduction (p<0.05). AST was increased after treatment with CCl4. Treatment with Moringa oleifera leaf reveals a dose-dependent significant reduction (p≤ 0.05). No significant reduction occurred for ALP in comparison to only CCl4 -treated group, but in comparison with the normal control.

Conclusions: The result of this study showed that aqueous Moringa oleifera leaf extract may have hepatoprotective action against CCl4-induced liver damage in rats.
Effect of Organic Manures and Boron on Growth and Yield of Chickpea (Cicer arietinum L.)
Authors: Reddy G. Amarnath , Umesha C.
Published: May 2022

A field experiment was conducted during Rabi 2021 at Crop Research Farm, Department of Agronomy, SHUATS, Prayagraj (U.P). The soil of experimental plot was sandy loam in texture, nearly neutral in soil reaction (pH 7.1), low in organic carbon (0.36%), available N (171.48 kg/ha), available P (15.2 kg/ha) and available K (232.5 kg/ha). The experiment was laid out in Randomized Block Design with nine treatments each replicated thrice on the basis of one year experimentation. The treatments which are T1: Vermicompost 3 t/ha + Boron @ 1 kg/ha, T2: Vermicompost 3 t/ha + Boron @ 1.5 kg/ha, T3: Vermicompost 3 t/ha + Boron @ 2 kg/ha, T4: Poultry manure 4 t/ha + Boron @ 1 kg/ha, T5: Poultry manure 4 t/ha + Boron @ 1.5 kg/ha, T6: Poultry manure 4 t/ha + Boron @ 2 kg/ha, T7: Farmyard Manure 5 t/ha + Boron @ 1 kg/ha, T8: Farmyard Manure 5 t/ha + Boron @ 1.5 kg/ha, T9: Farmyard Manure 5 t/ha + Boron @ 2 kg/ha are used. The results showed that application of Poultry manure 4 t/ha + Boron @ 2 kg/ha was recorded significantly higher Plant height (42.45 cm), No. of Nodules/plant (19.74) and Plant dry weight (8.63 g/plant). Significantly highest Pods/plant (30.06), Seeds/Pod (1.80), Test weight (223.07 g), Seed yield (1811.28 kg/ha), Stover yield (3217.59 kg/ha) was obtained in the treatment of Poultry manure 4 t/ha + Boron @ 2 kg/ha as compared to other treatments.
Learner Engagement in Optional Discussion Forums: A Reflection on An Online Statistics Course
Authors:   Grand Canyon University, Zhang Ulyshen Tianyi
Published: May 2022

When teaching pre-loaded and ready-to-use online courses, online instructors can integrate some optional discussion forums to tailor their instructions and to redirect teaching to meet instructional objectives. My teaching experiences, however, have revealed a lack of learner engagement in such optional discussion forums. Keeping this problem in mind, I explored possible ways to design and incorporate optional discussion forums in a pre-loaded online statistics course. Learners in this course were non-traditional doctoral learners, and they demonstrated satisfying engagement in these optional discussion forums. Therefore, in this reflection paper, I describe the process to design these optional discussion topics, evaluate learner engagement in optional discussion forums through three dimensions, and share major instructional strategies I used during this course to cultivate student engagement to work on these optional discussion topics. Keywords: Cognitive engagement, behavioral engagement, emotional engagement, deep learning, expectancy-value motivation theory, classroom assessment techniques
Terrorismo na América do Sul
Authors: Henriques Lima Priscila
Published: May 2022

Resenha do livro SILVA, Francisco Carlos Teixeira da; CHAVES, Daniel Santiago (0rgs). Terrorismo na América do Sul: uma ótica brasileira. Rio de Janeiro: Editora Multifoco, 2010, 310p
Mulher, sindicalismo rural e relações de poder
Authors: Oliveira Amorim Érika , Louise de Carvalho Fiúza Ana
Published: May 2022

: A expansão dos estudos sobre a mulher está relacionada à luta pela inserção no mercado de trabalho, aos movimentos feministas e também a novos paradigmas associados às dinâmicas das relações entre os sexos. A visibilidade da mulher rural noespaço público representa rupturas com o nosso passado patriarcal e a estrutura androcêntrica que persiste há tempos e pode contribuir para a construção de novas identidades femininas no campo. O presente trabalho pretende analisar a construção dasrelações de poder no âmbito da participação da mulher rural em instituições de representação coletiva, partindo do pressuposto de que a atuação política representa fator gerador de novas perspectivas de poder para trabalhadoras rurais nos âmbitospúblico e privado. Visa contribuir para debates acerca da inserção das mulheres nos espaços públicos e as implicações no espaço doméstico.
Práticas amorosas e afetivas na Paraíba (séculos XIX e XX): o papel da Família, da Igreja e do Estado nas tentativas de regularização social
Authors: Olimpio de Santana Rosemere
Published: May 2022

Ao problematizar os discursos produzidos em torno dos lugares institucionais, ou seja, a família, a Igreja e o Estado, articulamos a esse tema a prática do rapto consentido, posto que tal prática quebrava muitos acordos entre as famílias, desmontavaregras morais e apontava para novas configurações - as relações amorosas. Assim, analisaremos o rapto como lugar de tensões que transcendem o simples fato de resistência a uma ordem patriarcal, mas que também institui uma alternativa para aspráticas amorosas. E, ainda, o lugar que ocupavam as mulheres, que se mostraram, ao longo da pesquisa, não apenas como vítimas ou seduzidas, mas também sujeitos de suas ações e desejos.
“Um sujeito bêbado como um inglês”: a visão japonesa dos ocidentais no relato de Isabella Bird(1885)
Authors: Henrich Reichert Emannuel
Published: May 2022

Este artigo analisa a visão que os japoneses tinham dos ocidentais no final do século 19, baseando-se nas atitudes descritas no relato de viagem intitulado Unbeaten Tracks in Japan, escrito pela viajante inglesa Isabella Bird, em 1885. Conclui-se que asconcepções japonesas sobre o assunto ainda estavam em gestação, pois a população do interior sentia grande curiosidade por estrangeiros, sem, no entanto, saber muito sobre eles. Os habitantes de portos abertos ao comércio internacional, por sua vez, tinham maior familiaridade com os estrangeiros e uma visão dos ocidentais como rudes e ignorantes das regras de boa conduta.
O triunfo das aparências: poder e moda no Segundo Império francês
Authors: Debom Paulo
Published: May 2022

Esse artigo – parte de minha pesquisa de Doutorado em andamento – tem por objetivo refletir sobre o processo de construção da imagem pública de Napoleão III. Partindo da análise de sua trajetória, de seus discursos e da moda durante seu governo,esse texto analisa as estratégias do soberano para forjar seu poder.
Populismos, relações de poder e cultura política na história do tempo presente: América Latina dos anos 30 aos dias de hoje.
Authors: Henrique Campello Torres Pedro
Published: May 2022

O presente artigo aborda o polêmico termo Populismo. Apesar de suas ramificações internacionais, o tema central são as apropriações, os usos e abusos em relação à história recente da América Latina: de 1930 aos dias de hoje. O assunto,mesmo tendo sido muito trabalhado, ainda não ganhou um estudo criterioso e definitivo. A palavra, que por ora se torna conceito, continua sendo empregado de maneiras distintas em diferentes partes do mundo e com semânticas completamente variáveis, desde seu aparecimento registrado na Rússia do final do século XIX. Entretanto, não acredito que devemos banalizar o uso do termo, reduzindo sua interpretação a uma ausência de teor explicativo. Pelo contrário, devemos atestar relevância a um conceito que detenha tamanho impacto sobre os agentes sociais durante uma temporalidade longa. Entendê-lo e explicá-lo é difícil, mas esse será o desafio.
Endomembrane‐mediated storage protein trafficking in plants: Golgi‐dependent or Golgi‐independent?
Authors: Ren Yulong , Wang Yongfei , Zhang Yu , Pan Tian , Duan Erchao , Bao Xiuhao , Zhu Jianping , Teng Xuan , Zhang Pengcheng , Gu Chuanwei , Dong Hui , Wang Fan , Wang Yunlong , Bao Yiqun , Wang Yihua , Wan Jianmin
Published: May 2022

Seed storage proteins (SSPs) accumulated within plant seeds constitute the major protein nutrition sources for human and livestock. SSPs are synthesized on the endoplasmic reticulum and are then deposited in plant‐specific protein bodies, including endoplasmic reticulum‐derived protein bodies and protein storage vacuoles. Plant seeds have evolved a distinct endomembrane system to accomplish SSP transport. There are two distinct types of trafficking pathways contributing to SSP delivery to protein storage vacuoles: one is Golgi‐dependent and the other is Golgi‐independent. In recent years, molecular, genetic, and biochemical studies have shed light on the complex network controlling SSP trafficking, to which both evolutionarily conserved molecular machineries and plant‐unique regulators contribute. In this review, we discuss current knowledge of protein body biogenesis and endomembrane‐mediated SSP transport, focusing on endoplasmic reticulum export and post‐Golgi traffic. This knowledge supports a dominant role for the Golgi‐dependent pathways in SSP transport in Arabidopsis and rice. In addition, we describe cutting‐edge strategies for dissecting the endomembrane trafficking system in plant seeds to advance the field.
Technical note: Institutional solution of clinical cine MRI for tumor motion evaluation in radiotherapy
Authors: Kim Taeho , Wu Yu , Ji Zhen , Gach H. Michael , Knutson Nels , Mackey Stacie , Schmidt Matthew
Published: May 2022

Purpose

Since 4D‐MRI is inadequate to capture dynamic respiratory variations, real‐time cinematographic (cine) MRI is actively used in MR‐guided radiotherapy (MRgRT) for tumor motion evaluation, delineation, and tracking. However, most radiotherapy imaging platforms do not support the format of cine MRI from clinical MRI systems. This study developed an institutional solution of clinical cine MRI for tumor motion evaluation in radiotherapy applications.

Methods

Cine MRI manipulation software (called Cine Viewer) was developed within a commercial Treatment Planning System (TPS). It consists of (1) single/orthogonal viewers, (2) display controllers, (3) measurement grids/markers, and (4) manual contouring tools.

Results

The institutional solution of clinical cine MRI incorporated with radiotherapy application was assessed through case presentations (liver cancer). Cine Viewer loaded cine MRIs from 1.5T Philips Ingenia MRI, handling MRI DICOM format. The measurement grids and markers were used to quantify the displacement of anatomical structures in addition to the tumor. The contouring tool was utilized to localize the tumor and surrogates on the designated frame. The stacks of the contours were exhibited to present the ranges of tumor and surrogate motions. For example, the stacks of the tumor contours from case‐1 were used to determine the ranges of tumor motions (∼8.17 mm on the x‐direction [AP‐direction] and ∼14 mm on the y‐direction [SI‐direction]). In addition, the patterns of the displacement of the contours over frames were analyzed and reported using in‐house software. In the case‐1 review, the tumor was displaced from +146.0 mm on the x‐direction and +125.0 mm on the y‐direction from the ROI of the abdominal surface.

Conclusion

We demonstrated the institutional solution of clinical cine MRI in radiotherapy. The proposed tools can streamline the utilization of cine MRI for tumor motion evaluation using Eclipse for treatment planning.
Thermodynamic Evaluation of the system Ta–O and Preliminary Assessment of the Systems Al–Nb–O and Al–Ta–O
Authors: Gebauer Julian , Franke Peter , Seifert Hans Jürgen
Published: May 2022

The binary tantalum–oxygen system is assessed using the CALculation of PHase Diagrams (CALPHAD) method with experimental data from the literature. The oxygen solubility in the Ta solid‐solution phase is discussed and modeled. The low‐ and high‐temperature modifications of Ta2O5 are described as stoichiometric compounds. This dataset is extended into the ternary Al–Ta–O system by complementing it with binary datasets for Al–O and Al–Ta from the literature and adding mixed‐oxide AlTaO4. The dataset for the ternary system Al–Nb–O is created by combining the three corresponding binary datasets from the literature and by assessing the quasibinary section Al2O3–Nb2O5. The ternary aluminum niobates are described as stoichiometric compounds. Phase equilibria between refractory metals and alumina at high temperature are discussed.
A New Approach for Sintering Simulation of Irregularly Shaped Powder Particles—Part II: Statistical Powder Modeling
Authors: Weiner Max , Zienert Tilo , Schmidtchen Matthias , Hubálková Jana , Aneziris Christos G. , Prahl Ulrich
Published: May 2022

Current simulations of sintering processes work often with heavily idealized powder geometries. As sintering is mainly driven by gradients of chemical potential due to surface curvatures, a realistic description of the particle geometry is essential for achieving precise simulation results. In previous work, a model able to simulate sintering behavior of irregularly shaped particles was shown. Herein, a statistical approach for description of particles’ morphology in a powder mixture is developed by fitting a simplified particle shape model on image data. The obtained data are analyzed and conditioned for input into sintering simulation. Instead of building an equivalent volume cell of particles, as common, a Monte Carlo approach is applied to describe the sintering behavior of the powder. The resulting distributions of sintering time curves are analyzed regarding the influence of the morphology description in comparison to circular particles. Using thumb rules of Cohen's effect size, a small effect on shrinkage and a medium effect on neck radii is observed.
Effect of Heat Treatment on the Microstructure and Mechanical Properties of Al–9Si–0.4Mg–0.1Cu Alloy
Authors: Guo Binxu , Chang Liang , Dai Jiahang , Ding Yuming , Li Ri , Ding Jian , Li Chong , Tang Ying , Xia Xingchuan , Chen Xueguang , Song Kaihong , Liu Yongchang
Published: May 2022

Herein, effect of heat treatment on the microstructure and mechanical properties of a newly developed Al–9Si–0.4Mg–0.1Cu alloy treated by Al–6Sr–7La is investigated, and optimal T6 heat treatment process parameters are determined through optical microscopy (OM), scanning electron microscopy (SEM), transmission electron microscopy (TEM) analysis, and quantitative statistics. The results show that the distribution of α‐Al is more uniform after T6 heat treatment (solution treated at 540 °C for 5 h and aged at 170 °C for 6 h) with eutectic silicon possessing fine grain and high roundness. Meanwhile, Al–6Sr–7La increases peak aging hardness and reduces peak aging time. During the under‐aging process, a large amount of Guinier Preston zone and a small amount of Mg5Si6 phase precipitate, which have strengthening effect on the alloy. At peak aging state, the coherent precipitated Mg5Si6 phase in α‐Al leads to the highest microhardness. Continuing to prolong aging time, the coherent relationship between metastable phase Mg5Si6 and the matrix is weakened, resulting in the decrease in microhardness. In addition, after T6 heat treatment, both tensile strength and elongation of the alloy are significantly improved and the reasons are discussed.
Multiscale Polymeric Materials for Advanced Lithium Battery Applications
Authors: Kang Jieun , Han Dong‐Yeob , Kim Sungho , Ryu Jaegeon , Park Soojin
Published: May 2022

Riding on the rapid growth in electric vehicles and the stationary energy storage market, high‐energy‐density lithium‐ion batteries and next‐generation rechargeable batteries (i.e., advanced batteries) have been long‐accepted as essential building blocks for future technology reaching the specific energy density of 400 Wh kg−1 at the cell‐level. Such progress, mainly driven by the emerging electrode materials or electrolytes, necessitates the development of polymeric materials with advanced functionalities in the battery to address new challenges. Therefore, it is urgently required to understand the basic chemistry and essential research directions in polymeric materials and establish a library for the polymeric materials that enables the development of advanced batteries. Herein, based on indispensable polymeric materials in advanced high‐energy‐density lithium‐ion, lithium–sulfur, lithium‐metal, and dual‐ion battery chemistry, the key research directions of polymeric materials for achieving high‐energy‐density and safety are summarized and design strategies for further improving performance are examined. Furthermore, the challenges of polymeric materials for advanced battery technologies are discussed.
Bending‐Insensitive Flexible SERS Sensor for Stable and Sensitive Detection on Curved Surfaces
Authors: Lee Taeksu , Kim Woochang , Kwon Soongeun , Park Jinsung , Park Jong‐Oh , Bang Doyeon
Published: May 2022

Surface‐enhanced Raman scattering (SERS) based flexible sensing technology has been considered an essential candidate for future diagnostics in diverse fields. To obtain a reliable signal from the flexible SERS sensor, signal reproducibility even when the substrates are bent is highly desirable because there are various curvatures in the practical applications. However, this remains challenging because the “hot‐spots” were created between the individual nanostructures on the surface of the previous flexible SERS sensor. The distance between each nanostructure varied through the bending of the sensor, leading to an adverse effect on the unform intensity of the Raman signal. Herein, a bending‐insensitive flexible SERS substrate is reported for reliable and sensitive sensing on curved surfaces. It is based on silver nanodendrites on the surface of graphene‐modified PI film via electrodeposition. Numerous hot spots are created between the trunk‐branch and branch‐branch junctions inside individual silver dendrites. The inherent hot‐spots of silver nanodendrites exhibit a uniform and extremely enhanced Raman signal under the bending of the substrate, because the morphology of silver nanodendrites is insensitive to diverse degrees of bending. Thus, the flexible SERS sensor can detect 10−12 m (in buffer solution) and 10−8 m (serum‐containing condition) of 6‐thioguanine on arbitrary curved surfaces.
Electrocatalytic Selenium Redox Reaction for High‐Mass‐Loading Zinc‐Selenium Batteries with Improved Kinetics and Selenium Utilization
Authors: Ma Longtao , Ying Yiran , Chen Shengmei , Chen Ze , Li Hongfei , Huang Haitao , Zhao Lingzhi , Zhi Chunyi
Published: May 2022

Batteries usually deliver mass loading‐dependent electrochemical performance. Taking the selenium cathode as an example, the Se reaction kinetics, utilization, and cycling lifespan seriously deteriorate with increased Se mass loading. Here, an electrocatalytic Se reduction/oxidation reaction strategy to realize high‐Se‐loading Zn||Se batteries with fast kinetics and high Se utilization is proposed. Specifically, the synergetic effects of Cu and Co transition‐metal species inside the channel structure of the host can effectively immobilize and catalytically convert Sen during cycling, which thus facilitates Se utilization and 6‐electron (Se4+ ↔ Se2–) conversion kinetics. In particular, the Cu[Co(CN)6] host exhibits a remarkably low energy barrier (1.63 kJ mol–1) and low Tafel slope (95.23 mV dec–1) for the Se reduction, and the highest current response for Se oxidation. Accordingly, the Zn battery employing a Se‐in‐Cu[Co(CN)6] cathode delivers a capacity of 664.7 mAh g–1 at 0.2 A g–1, an excellent rate capability with 430.6 mAh g–1 achieved even at 10 A g–1, and long‐cyclic life over 6000 cycles with 90.6% capacity retention. Furthermore, an A‐h‐level (≈1350 mAh) Zn||Se pouch‐type battery with high Se loading (≈12.3 mg(Se) cm–2) shows a high Se utilization of 83.3% and outstanding cyclic stability with 89.4% initial capacity retained after 400 cycles at exceeding 98% Coulombic efficiency.
Treosulfan compared with reduced‐intensity busulfan improves allogeneic hematopoietic cell transplantation outcomes of older acute myeloid leukemia and myelodysplastic syndrome patients: Final analysis of a prospective randomized trial
Authors: Beelen Dietrich W. , Stelljes Matthias , Reményi Péter , Wagner‐Drouet Eva‐Maria , Dreger Peter , Bethge Wolfgang , Ciceri Fabio , Stölzel Friedrich , Junghanß Christian , Labussiere‐Wallet Hélène , Schaefer‐Eckart Kerstin , Grigoleit Goetz U. , Scheid Christof , Patriarca Francesca , Rambaldi Alessandro , Niederwieser Dietger , Hilgendorf Inken , Russo Domenico , Socié Gérard , Holler Ernst , Glass Bertram , Casper Jochen , Wulf Gerald , Basara Nadezda , Bieniaszewska Maria , Stuhler Gernot , Verbeek Mareike , La Rocca Ursula , Finke Jürgen , Benedetti Fabio , Pichlmeier Uwe , Klein Anja , Baumgart Joachim , Markiewicz Miroslaw
Published: May 2022

The phase III study was designed to compare event‐free survival (EFS) after treosulfan‐based conditioning with a widely applied reduced‐intensity conditioning (RIC) busulfan regimen in older or comorbid patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) undergoing allogeneic hematopoietic cell transplantation (HCT). A previously reported confirmatory interim analysis of the randomized clinical study including 476 patients demonstrated statistically significant noninferiority for treosulfan with clinically meaningful improvement in EFS. Here, the final study results and pre‐specified subgroup analyses of all 570 randomized patients with completed longer‐term follow‐up are presented. Patients presenting HCT‐specific comorbidity index >2 or aged ≥50 years were randomly assigned (1:1) to intravenous (IV) fludarabine with either treosulfan (30 g/m2 IV) or busulfan (6.4 mg/kg IV) after stratification by disease risk group, donor type, and participating institution. The primary endpoint was EFS with disease recurrence, graft failure, or death from any cause as events. EFS of patients (median age 60 years) was superior after treosulfan compared to RIC busulfan: 36‐months‐EFS rate 59.5% (95% CI, 52.2–66.1) vs. 49.7% (95% CI, 43.3–55.7) with a hazard ratio (HR) of 0.64 (95% CI, 0.49–0.84), p = 0.0006. Likewise, overall survival (OS) with treosulfan was superior compared to busulfan: 36‐month‐OS rate 66.8% vs. 56.3%; HR 0.64 (95% CI, 0.48–0.87), p = 0.0037. Post hoc analyses revealed that these differences were consistent with the confirmatory interim analysis, and thereby the treosulfan regimen appears particularly suitable for older AML and MDS patients.
Photo‐Driven Radical Addition/Cyclization of Biaryl Vinyl Ketones with CF3SO2Na and ArCF2CO2K without an External Photocatalyst
Authors: Yang Xingyu , Liu Jie , Gao Yanhui , Wang Lei , Zhang Yicheng , Li Pinhua
Published: May 2022

A new strategy for the preparation of 10,10‐disubsituedphenanthren‐9(10H)‐ones via a photo‐driven radical addition/cyclization of biaryl vinyl ketones with CF3SO2Na and ArCF2CO2K has been developed. The reactions can proceed smoothly in air at room temperature under 380–385 nm LED irradiation without any external photocatalyst, and the corresponding products were obtained in 55–89% yields.
Gast‐modulierte Zirkular Polarisierte Lumineszenz via Ligand‐zu‐Ligand Chiralitätstransfer in Heteroleptischen PdII Käfigen
Authors: Wu Kai , Tessarolo Jacopo , Baksi Ananya , Clever Guido H.
Published: May 2022

Die Mehrkomponenten‐Assemblierung metallo‐supramolekularer Komplexe erlaubt die gezielte Kombination verschiedener Bausteine. Definierte multifunktionale Wirte mit einer zugänglichen Kavität können so auf nicht‐statistische Weise dargestellt werden. Wir nutzen unsere Methode der formkomplementären Assemblierung (shape complementary assembly, SCA), um erstmalig die integrative Selbstsortierung heteroleptischer PdII‐Käfige zu erzielen, welche eine durch den Gast modulierte zirkular polarisierte Lumineszenz (circularly polarized luminescence, CPL) zeigen. Ein enantiomerenreiner Ligand auf Basis von Helicen (M‐ oder P‐Konfiguration) wird dabei mit einem nicht‐chiralen, emittierenden Liganden auf Basis von Fluorenon (A oder B) kombiniert, um eine Reihe von Pd2L2L′2 Käfigen zu bilden. Die modulare Strategie ermöglicht es, die chirale Information des Helicens auf das gesamte supramolekulare System zu übertragen, was zu CPL‐Emission aus der nicht‐chiralen Komponente führt. Die Bindung eines Gastes führt zu einer 4‐fachen Erhöhung der CPL‐Intensität. Das hier vorgestellte System bietet das Potential, Bibliotheken multifunktionaler Materialien herzustellen, welche in der molekularen Erkennung, der enantioselektiven Photo‐Redox‐Katalyse und der Informationsverarbeitung eingesetzt werden können.
Green‐Light‐Driven Reductive Elimination of Chlorine from a Carbene‐Xanthylium Gold(III) Complex
Authors: Park Gyeongjin , Karimi Mohammadjavad , Liu Wei‐Chun , Gabbaï François P.
Published: May 2022

With the discovery of late transition metal platforms that support clean photoreductive halogen eliminations, we now describe an indazol‐3‐ylidene gold trichloride complex ([7]+) decorated at the 4‐position by a xanthylium unit. This orange complex features a low energy band in the visible part of the spectrum, assigned to the charge transfer excitation of the indazol‐3‐ylidene/xanthylium donor/acceptor dyad. Green‐light irradiation of this complex in the presence of a chlorine trap elicits the clean photoelimination of chlorine radicals, producing the corresponding gold(I) complex. This visible‐light‐induced photoreduction is very efficient, reaching quantum yields close to 10 %. A neutral analog of [7]+ featuring an anthryl group rather than a xanthylium unit proved to be perfectly photostable, supporting the importance of the xanthylium‐based photoredox unit present in [7]+.
Reflections on Implementing the POTT Program in a Master's Clinical Program
Authors: Pennant Anthony , Shamoon Zain
Published: May 2022

The person of the therapist (POTT) framework is a model of therapist training that can enhance clinicians' attunement and further clinical efficacy. In this autoethnography, two graduate school professors of colour detail their experience of implementing the POTT framework overlaid to academic work. This article presents specific arguments for the use of this model as it furthers therapist accountability and responsiveness. The model's advantages in clinical graduate training are also reviewed.
Magnetic properties of the mononuclear iron (III) complexes with biphenyl‐disubstituted Schiff base ligand: EPR and SQUID study
Authors: Vorobeva Valerya , Starichenko Denis , Gruzdev Matvey , Chervonova Ulyana , Zaripov Ruslan , Korolev Aleksander
Published: May 2022

The magnetic features of the mononuclear iron (III) complexes [Fe(L)2]+X−with tridentate Schiff base ligands [where L is 4‐(4‐diphenylcarboxy)‐2′‐oxysalicylidene‐N′‐ethylene‐N‐ethylene‐2′‐amine‐(carboxy‐4‐diphenyl) and X− = Cl−(1), PF6−(2) and NO3−(3) counter‐ions] have been studied by electron paramagnetic resonance (EPR) spectroscopy, SQUID (superconducting quantum interference device) magnetometry (solid), and Evans1H nuclear magnetic resonance  method (solution). EPR established that compounds (1) and (2) consist of two types high‐spin (HS, S = 5/2) centers with weak distorted and strong low‐symmetry octahedral crystal fields. The signals from low‐spin centers (LS, S = 1/2) of Fe (III) are observed in the spectra of compounds2and3. SQUID revealed permanent HS behavior in (1) and mixed LS + HS in (2), (3) in wide temperature range, while solution method—only HS. Magnetic measurements allowed to estimate part of HS and LS fractions and detected antiferromagnetic exchange interactions between the neighboring Fe (III) ions in complexes.“
Active Shooter Preparedness: Is Your OR Ready?
Authors: Scott‐Herring Mary
Published: May 2022

Active shooter events, including those in health care facilities, are expected to increase in incidence. Perioperative personnel may be underprepared for such an event. Understanding how to make the best decision regarding whether to escape, hide, or fight, and being aware of the communication channels during these types of events are crucial to adequate preparation. Health care facilities and critical areas such as the OR should be prepared for an active shooter event. This article briefly describes a firsthand shooting event experience at Johns Hopkins Hospital and includes a review of the literature on active shooter events in health care settings to determine the most practical application of event preparedness for staff members working in the OR. It also discusses the highly relevant concept of patient abandonment.
Poly(3,4‐ethylenedioxythiophene):Poly(styrene sulfonate) in antibacterial, tissue engineering and biosensors applications: Progress, challenges and perspectives
Authors: Gupta Sonal , Datt Ram , Mishra Anamika , Tsoi Wing Chung , Patra Asit , Bober Patrycja
Published: May 2022

With the advancement of applications in biomedicines and bioelectronics, conducting polymers have attained huge significant attention. For such applications, poly(3,4‐ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) is considered a potential conducting polymer because of its low cost, considerable stability, high conductivity and mechanical strength. Most importantly, its easy aqueous solution processability makes it more attractive. Over the last few years, PEDOT:PSS has been predominantly explored and investigated for different optoelectronic flexible devices, and recently it has been studied for biomedical applications. PEDOT:PSS based materials have made progress in biomedicines due to their properties such as biocompatibility, cell proliferation, antibacterial, nontoxicity and so forth. To adjust the desirable properties, special attention is required for altering the structure of PEDOT:PSS material. PEDOT:PSS offers excellent antibacterial properties against both gram‐positive and gram‐negative bacteria. Moreover, PEDOT:PSS demonstrates an important role in sensing human body humidity, pressure control, glucose detection, as well as employed in human sweat sensors. Besides these, PEDOT:PSS has been studied as a scaffold for endothelial cell preservation. There are several issues which need to be resolved in the future, such as improved biocompatibility and stability to explore the PEDOT:PSS based composite materials in biomedical applications. However, a related review article is lacking, directed on the PEDOT:PSS biomedical applications, namely, antibacterial, tissue engineering, and biosensing. Therefore, the current article summarizes importance of PEDOT:PSS for biomedical applications, and main emphasis is given to its recent advances, challenges and perspectives.
TMEDA‐Catalyzed Regioselective Decarboalkoxy C−N Bond Formation: A Unified Direct Access to Indolo[2,1‐a]isoquinoline and Dibenzopyrrocoline Alkaloids
Authors: Yadav Lalit , Kumar Shyamlal Bharti Rajesh , Tiwari Mohit K. , Rahaman T. A Abdul , Sen Janmejaya , Chaudhary Sandeep
Published: May 2022

An unprecedented TMEDA‐catalyzed, regioselective, decarboethoxy direct C−N coupling protocol towards the synthesis of dibenzopyrrocolines 17 a–i and 5,6‐dihydroindolo[2,1‐a]isoquinoline 15 a–f/18 a–c alkaloids via the identification of N,N,N′,N′‐tetramethylethylenediamine (TMEDA) as a homogeneous catalyst is reported. The transition‐metal‐free, TMEDA‐catalytic novel protocol is operationally simple and showed a wide range of functional group tolerance and substrate compatibility. The gram‐scale application and synthesis of naturally occurring Cryptaustoline (dibenzopyrrocoline) alkaloid, further highlights the importance and versatile nature of the developed protocol. This finding also offers a TMEDA‐catalyzed direct synthesis of dibenzopyrrocolines and substituted 5,6‐dihydroindolo[2,1‐a]isoquinoline compounds in a one‐pot. The probable reaction pathway involves the free‐radical sequential approach via a single electron transfer (SET) mechanism.
Chemoenzymatic Synthesis of Globo‐series Glycosphingolipids and Evaluation of Their Immunosuppressive Activities
Authors: Chiang Pei‐Yun , Adak Avijit K. , Liang Wei‐Lun , Tsai Chen‐Yen , Tseng Hsin‐Kai , Cheng Jing‐Yan , Hwu Jih Ru , Yu Alice L. , Hung Jung‐Tung , Lin Chun‐Cheng
Published: May 2022

Glycosphingolipids (GSLs) play essential roles in many important biological processes, making them attractive synthetic targets. In this paper, a viable chemoenzymatic method is described for the synthesis of globo‐series GSLs, namely, Gb4, Gb5, SSEA‐4, and Globo H. The strategy uses a chemically synthesized lactoside acceptor equipped with a partial ceramide structure that is uniquely extended by glycosyltransferases in a highly efficient one‐pot multiple enzyme (OPME) procedure. A direct and quantitative conversion of Gb4 sphingosine to Globo H sphingosine is achieved by performing two‐sequential OPME glycosylations. A reduction andN‐acylation protocol allows facile incorporation of various fatty acids into the lipid portions of the GSLs. The chemically well‐defined lipid‐modified Globo H‐GSLs displayed some differences in their immunosuppressive activities, which may benefit the structural modifications of Globo H ceramides in finding new types of immunosuppressive agents. The strategy outlined in this work should be applicable to the rapid access to other complex GSLs.