bluuebunny/crossref_metadata_2025 huggingface dataset:
Cognitive linguistics in foreign language teaching: problems and prospects (by the example of teaching English at a language university)
Authors: Motov Sergei V.
Published: October 2022

The features, problems and prospects of using cognitive linguistics in teaching a foreign language in general and English in particular in a language university are considered. The main features and postulates of cognitive linguistics that are significant in the context of foreign language learning are given. The main promising areas of application of linguocognitive science for teaching such aspects of the English language as its vocabulary and grammar are considered. The features of teaching some linguistic phenomena of the English language, in particular, English prepositions, as well as relevant cognitive mechanisms, such as conceptual metaphor and conceptual metonymy, are described in detail. The functions of these mechanisms and possible examples of their productive use in teaching a foreign language are given. Based on the analysis of a wide range of scientific papers on the research problem, a classification of various formats of the use of cognitive linguistics in teaching a foreign language is proposed. Each of the proposed formats is described in detail, the corresponding strengths and weaknesses are given. The possibility of developing the concept of a linguocognitive approach to teaching English in a language university is explained. The main features of this approach, its strengths, as well as promising directions for the development of the concept of a linguocognitive approach to teaching English in a language university are given.
The use of famous paintings as means of cognitive visualization in teaching language
Authors: Zueva Victoria V.
Published: October 2022

The relevance of the research topic is due to close attention of scientific and pedagogical public to the issues of cognitive education. Over the past years there has been sustainable interest to various methods of cognitive visualization and a search for new forms of work for the formation of cognitive interest and development of reflective mental activity. Purpose: to substantiate the effectiveness of the use of famous paintings as cognitive visual material to enhance students’ learning and cognitive activity at English classes and to present the types of tasks with them. Research methods: research methods are based on an analytical review of scientific sources on issues of cognitive education, the use of visual aids in the educational process and generalization of personal pedagogical experience of using the proposed tasks at English classes in the 1st year of the Faculty of Linguistics and Intercultural Communication of the Odintsovo branch of the Moscow State Institute of International Relations (University) of Ministry of Foreign Affairs of Russian Federation. Results: the article presents examples of tasks which generate interest, stimulate cognitive activity and contribute to the development of all components of communicative competence. It is concluded that within the framework of the communicative and cognitive approach, the use of paintings as visual visualization has great potential in the field of motivation, creation of a positive attitude towards learning and contributes to the effective solution of several educational and pedagogical tasks.
Psychological and pedagogical conditions for organizing the process of teaching students of linguistic specialties a foreign written speech statement based on the method of mutual assessment
Authors: Kretov Denis V.
Published: October 2022

The method of mutual assessment is one of the methods of problem teaching of a foreign language. It consists in the mutual study of each other’s written works by students with the aim of commenting and evaluating them for further refinement. The implementation of this method in conditions of blended learning, when some of the stages of project activities are carried out by students in the classroom, and some – individually or collectively outside the classroom on the platform of one of the Internet services, seems quite promising from the standpoint of linguodidactics. At the same time, the successful implementation of this method in practice requires taking into account a number of psychological and pedagogical conditions. Among them, the we include the following: a) the motivation of students to participate in the mutual assessment of written works based on the implementation of a blended learning form through information and communication technologies; b) the use of cooperative learning technology; c) teaching students the format of writing reviews on the written work of classmates; d) the presence of a phased learning technology, which will define a clear sequence of learning stages and spell out the functions of a student – the author of a written work, classmates – reviewers and a teacher; e) monitoring of project work of students by a teacher with constant feedback. We describe in detail and justify each of the conditions.
Pertanggungjawaban Pidana Pelaku Peredaran Alat Rapid Test Sebagai Alat Kesehatan Tanpa Izin Edar
Authors: Nabilah Khansa Aribah Milansari
Published: October 2022

AbstractIn the health sector, pharmaceutical preparations and medical devices that will be circulated to the public as well as the authorities in the use of these devices must be guaranteed safety in order to ensure that the pharmaceutical preparations and medical devices do not endanger the users. However, in practice legal problems arise where there is a circulation of rapid test equipment that does not have a distribution permit. The purpose of this study was to find out whether the act of distributing rapid test equipment without a distribution permit is a criminal act and what form of criminal responsibility for the perpetrators of the circulation of rapid test equipment without a distribution permit is formed. From the conceptual approach and the statutory approach taken, it was concluded that the act of distributing rapid test equipment without a distribution permit violates Article 60 of Law Number 11 of 2020 concerning Job Creation. Then for the accountability of the perpetrators of the circulation of rapid test equipment without a distribution permit, sanctions can be imposed in accordance with Article 197 of the Health Law and Article 62 of the Consumer Protection Act.Keywords: Criminal Liability; Rapid Test Tool; Circulation Permit.
AbstrakDalam bidang kesehatan sediaan farmasi dan alat kesehatan yang akan diedarkan kepada masyarakat maupun pihak yang berwenang dalam penggunaan alat tersebut harus terjamin keamanannya guna memastikan bahwa sediaan farmasi maupun alat kesehatan tersebut tidak membahayakan penggunanya. Namun dalam praktiknya timbul permasalahan hukum dimana terdapat peredaran alat rapid test yang tidak memiliki izin edar. Tujuan penelitian ini adalah untuk mengetahui apakah perbuatan mengedarkan alat rapid test tanpa izin edar merupakan suatu tindak pidana dan bagaimana bentuk pertanggungjawaban piadna pelaku peredaran alat rapid test yang tidak memiliki izin edar tersebut. Dari pendekatan konseptual dan pendekatan perundang-undangan yang dilakukan, ditarik kesimpulan bahwa perbuatan mengedarkan alat rapid test tanpa izin edar melanggar Pasal 60 Undang-Undang Nomor 11 Tahun 2020 tentang Cipta Kerja. Kemudian untuk pertanggungjawaban pelaku peredaran alat rapid test tanpa izin edar tersebut dapat dikenakan sanksi sesuai pada pasal 197 Undang-Undang Kesehatan serta Pasal 62 Undang-Undang Perlindungan Konsumen.Kata Kunci: Pertanggungjawaban Pidana; Alat Rapid Test; Izin Edar.
Perlindungan Komunitas Lesbian, Gay, Biseksual dan Transgender (LGBT) di Kampus: Hukum HAM dan Kebebasan Akademik
Authors: Rohman Hidayad
Published: October 2022

AbstractIndonesia is a state of law and a country that upholds human rights. Although in the constitution there are no rules that specifically regulate the LGBT group. This thesis discusses the protection of the LGBT community on campus in terms of the legal system, human rights and the principles of academic freedom and how the state is responsible for fulfilling the rights of citizens, especially for LGBT groups on campus. The type of research used is the type of legal research with a conceptual approach and legislation in the perspective of human rights. This study shows that cases that occur in LGBT groups in Indonesia, especially in the campus environment, still receive less attention from the government. Cases that occur should make learning so that it does not happen again. In comparison to getting justice for LGBT people whose rights have been violated and discriminated against, there are several legal remedies by LGBT groups in the United States and Malaysia.Keywords: LGBT Groups; LGBT Groups on Campus; Legal Efforts for LGBT Groups.
AbstrakIndonesia merupakan negara hukum dan negara yang menjunjung tinggi hak asasi manusia. Meskipun dalam konstitusi tidak ada aturan yang secara spesifik mengatur mengenai kelompok LGBT. skripsi ini membahas mengenai perlindungan komunitas LGBT di kampus di tinjau dari sistem hukum, HAM dan prinsip-prinsip kebebasan akademik serta bagaimana tanggungjawab negara dalam hal pemenuhan hak warga negara khususnya bagi kelompok LGBT di kampus. Tipe penelitian yang digunakan adalah tipe penelitian hukum dengan pendekatan konseptual dan dan perundang-undangan dalam sudut pandang hak asasi manusia. Penelitian ini menunjukkan bahwa kasus yang terjadi pada kelompok LGBT di Indonesia khususnya dalam lingkungan kampus masih kurang mendapatkan perhatian dari pemerintah. Kasus yang terjadi seharusnya menjadikan pembelajaran agar tidak tejadi lagi. Sebagai perbandingan untuk mendapatkan keadilan bagi kelompok LGBT yang haknya dilanggar dan mendapatkan diskriminasi, terdapat beberapa upaya hukum yang dilakukan kelompok LGBT di Amerika Serikat dan Malaysia.Kata Kunci: Kelompok LGBT; Kelompok LGBT di Kampus; Upaya Hukum Kelompok LGBT.
Nearshore Wave Energy Resource Assessment for Off-grid Islands: A Case Study in Cuyo Island, Palawan, Philippines
Authors: Pacaldo Jonathan Cabiguen , Abundo Michael Lochinvar Sim
Published: October 2022

Electrifying off-grid and isolated islands in the Philippines remains one of the challenges that hinders community development. One of the solutions seen to ensure energy security, expand energy access and promote a low carbon future in this isolated islands is the use of renewable energy sources. This study wishes to determine the nearshore wave energy resource during monsoon seasons in Cuyo Island using a 40-year wave hindcast and 9-year on-site wind speed data to develop high resolution wave energy model using SWAN wave model, and assessed its annual energy production through matching with wave energy devices. Results shows that average significant wave height (Hs), peak period (Tp) and wave power density (Pd) during northeast monsoon are Hs = 1.35 m, Tp = 4.79 s and Pd = 4.05 kW/m respectively, while southwest monsoon which is sheltered by the mainland resulted to a lesser outcome, Hs = 0.52 m, Tp = 3.37 s and Pd = 0.34 kW/m. While the simulated model was observed to overestimate the wave energy resource (Bias = 0.398, RMSE = 0.54 and SI = 1.34), it has a strong relationship with the observed values (average r = 0.9). Its annual energy production is highest at Station 5, with AEPWaveBouy = 43.761 MWh, AEP-Pelamis = 216.786 MWh and AEPWave Dragon = 2462.66 MWh. At present, the minimum requirement for a wave energy development to be feasible is 5 kW/m, which in this case, Cuyo Island falls short, but with the continuous evolution of wave energy converters, applications on milder re-sources will soon materialized.
ANALYSIS OF INTEGRATED VILLAGE PLANNING TOWARDS INDEPENDENT VILLAGE IN KECAMATAN CILELES, LEBAK BANTEN DISTRICT
Authors: Aziz Alfida , Marzuki Faisal , Sumardjo Mahendro
Published: October 2022

This research was conducted in order to participate in advancing the Cileles Lebak Banten District, the purpose of this study was to identify the problems faced by the Cileles Banten District in order to become an Independent Village so that a concrete picture would be obtained about the extent of the obstacles to being able to get to an independent village, Members of the population. from the research were the Village Heads in Cileles Lebak Banten District. This research uses qualitative analysis methods. Three villages that have been able to make plans to become independent villages, the research sample is 12 villages in the Cileles sub-district using surveys and questionnaires using Google Form.
MEDIATOR KOMPETENSI INSTRUKTUR : DIGITAL SKILL DAN INDUSTRI 4.0 SKILLS-SETS TERHADAP KESIAPAN TENAGA KERJA INDONESIA DALAM MENGHADAPI DUNIA KERJA MASA DEPAN
Authors: Rizki Gusfa Winda  , Yulihasri  , Hendra Lukito
Published: October 2022

Penelitian yang dilakukan bertujuan untuk melakukan pengujian mediator kompetensi instruktur: digital sikll dan industry 4.0 skills-sets terhadap kesiapan tenaga kerja Indonesia dalam menghadapi dunia krja masa depan pada balai latihan kerja padang, sehingga nantinya akan dapat membantu balai latihan kerja padang untuk mengatasi masalah kesiapan tenaga kerja Indonesia dalam menghadapi dunia kerja masa depan. penelitian ini memamakai metode pendekatan kuantitatif dengan menggunakan teknik totak sampling sehingga didapatkan sampel sebanyak 160 responden yang merupakan calon tenaga kerja. Analisis data yang digunakan yaitu Smart PLS yang berguna mencari adanya pengaruh antar variabel dengan mediatornya. Hasil penelitian ini adalah adanya semakin tinggi keterampilan digital peserta pelatihan BLK Padang maka semakin tinggi kesiapan kerja perserta pelatihan dalam memasuki dunia kerja masa depan, semakin tinggi industri 4.0 digital skill-set peserta pelatihan BLK Padang maka semakin tinggi kesiapan kerja perserta pelatihan dalam memasuki dunia kerja masa depan, semakin tinggi kompetensi instruktur BLK Padang maka semakin tinggi kesiapan kerja perserta pelatihan dalam memasuki dunia kerja masa depan, semakin tinggi kompetensi intruktur pelatihan maka hubungan keterampilan digital peserta pelatihan BLKI Padang dengan kesiapan kerja perserta pelatihan dalam memasuki dunia kerja masa depan akan semakin kuat, semakin tinggi kompetensi intruktur pelatihan maka hubungan industri 4.0 skill-set peserta pelatihan BLKI Padang dengan kesiapan kerja perserta pelatihan dalam memasuki dunia kerja masa depan akan semakin kuat
PERAN CORE COMPETENCY BERBASIS MODEL TIROCA DALAM MENINGKATKAN KEUNGGULAN BERSAING PADA UMKM MAKANAN RINGAN DI KOTA CIMAHIPERAN CORE COMPETENCY BERBASIS MODEL TIROCA DALAM MENINGKATKAN KEUNGGULAN BERSAING PADA UMKM MAKANAN RINGAN DI KOTA CIMAHI
Authors: Gristira Nadia , Martha Fani Cahyandito  , Supiansyah
Published: October 2022

Penelitian ini bertujuan untuk mengetahui: (1) bagaimana core competency berbasis TIROCA dan keunggulan bersaing, (2) kontribusi core competency berbasis TIROCA dalam meningkatkan keunggulan bersaing pada UMKM industri makanan ringan di kota Cimahi. Sampel penelitian ini adalah para pelaku UMKM industri makanan ringan di kota Cimahi yang tergabung dalam Program Bala Beli dengan menggunakan metode sensus. Pengumpulan data dilakukan dengan kuesioner disebarkan langsung ke 62 pelaku UMKM industri makanan ringan di kota Cimahi. Metod menggunakan PLS. Hasil penelitian ini menunjukkan bahwa: (1) core competency berbasis TIROCA yang dimiliki UMKM industri makanan ringan di kota Cimahi dalam kategori unik dan keunggulan bersaing dinilai dalam kategori superior, (2) competency berbasis model TIROCA berpengaruh secara signifikan terhadap keunggulan bersaing, semakin unik core competency berbasis TIROCA maka semakin superior pula keunggulan bersaing yang dimiliki oleh para pelaku UMKM industri makanan ringan di kota Cimahi. Variabel core competency berbasis TIROCA dengan indikator organizational capabilities merupakan variabel dan indikator paling kuat sehingga aspek tersebut harus dibenahi dan diprioritaskan agar memiliki keunggulan bersaing dengan para kompetitornya.
PENGARUH KETERLIBATAN PEKERJAAN DAN KEPUASAN KERJA TERHADAP PERILAKU KEWARGANEGARAAN ORGANISASI (OCB) YANG DIMEDIASI OLEH KOMITMEN ORGANISASI DI PT TOP KARIR INDONESIA
Authors: Sholikhah  , Wiradendi Wolor Christian
Published: October 2022

Perilaku Kewarganegaraan Organisasi (OCB) diperlukan dalam suatu organisasi terlepas dari orientasinya, baik mencari keuntungan atau di bidang sosial, karena memungkinkan perusahaan untuk tumbuh lebih cepat dan melampaui pesaingnya. OCB menunjukkan kesediaan karyawan untuk bekerja di luar tanggung jawab mereka. Jika hal ini ada dan berkembang, maka perusahaan akan mampu meningkatkan kinerjanya sehingga tujuan tersebut akan tercapai. Penelitian ini bertujuan untuk mengetahui: Pertama, untuk mengkaji tentang keterlibatan pekerjaan, kepuasan kerja, komitmen organisasi, dan perilaku kewarganegaraan organisasi. Kedua, mengetahui pengaruh langsung dan tidak langsung antara keterlibatan pekerjaan dan kepuasan kerja terhadap OCB yang dimediasi oleh komitmen organisasi. Item kuesioner didistribusikan secara online melalui formulir Microsoft dengan pertanyaan terstruktur. Jumlah responden yang dikumpulkan sebanyak 77 orang. Data tersebut diolah menggunakan software SPSS 24, dan hasilnya menunjukkan bahwa keterlibatan pekerjaan, kepuasan kerja, dan komitmen organisasi berdampak positif terhadap OCB. Selain itu, komitmen organisasi memiliki peran mediasi antara keterlibatan pekerjaan dan kepuasan kerja di OCB.
BIOFILTER MANUFACTURE OF AZADIRACHTA INDICA LEAF POWDER AND ITS EFFECTIVENESS IN CAPTURING FREE RADICALS OF CIGARETTE SMOKE
Authors: Mulyono Agus
Published: October 2022

Free radicals from cigarette smoke are a dangerous part that must be found to counteract. This research aims to make a composite biofilter made from Azadirachta Indica to ward off/capture free radicals from cigarette smoke. This biofilter is made with Azadirachta Indica leaf powder added to polyethylene glycol as the matrix. The biofilter was then seen for its physical characteristics; the density and porosity were tested using SEM. Furthermore, a biofilter membrane is used to filter cigarette smoke. Cigarette smoke that passes through the biofilter is then analyzed using ESR for its free radical content. The results showed that the biofilter made from Azadirachta Indica leaves could absorb several types of suspected free radicals in cigarette smoke. Biofilters using PEG as a matrix with a mass of 0.9 and 1gr were the most effective in absorbing the suspected types of free radicals. SEM test showed an average pore size of 2-3 µm for a mass of 1gr with PEG as the matrix.
SMART SEAL BASE ON WIFI USING WEB SERVICE PHP
Authors: Syahwir Irawati Dewi , Suprijanto Suprijanto , Tentri Gayuh , Pratama Rayhan Putra
Published: October 2022

Technological developments, especially in the IoT (Internet of Things), play a significant role in various fields. In addition to achieving a modern and efficient work environment, IoT can also play a role in the security sector, which has now become a significant need. One of the roles of IoT in the security sector is that it can be applied to calibrated TMWE (Measuring, Dosing, Weighing, and Equipment). So that it can guarantee the correctness of the measurement results from the TMWE, continuous monitoring can be carried out so that fraud does not occur. One of the innovations in this regard is the smart seal. The use of smart seals is prioritized for fixed TMWE, which is vulnerable to theft and breaches. This system is designed based on IoT, which is integrated with cloud services and GPS systems that allow the use of web-based applications for online monitoring of seal conditions by users. Data from the seal will be sent to the server via wifi network and stored in a database, to be displayed in web service with a user, admin, and signer access. In addition to providing information to users about the seal’s location, the use of the GPS also aims to make it easier for admins to detect the seal’s location in the event of a violation.
IMPLEMENTATION OF TRS-398 PROTOCOL IN ROUTINE CALIBRATION OF LINAC BY DETERMINATION OF SLAB PHANTOM ON WATER PHANTOM CORRECTION FACTOR
Authors: Fauzi Azizallah , Aliyah Fitrotun , Darmawati Darmawati
Published: October 2022

The water phantom is used for LINAC calibration to measure absorbed dose radiation. Practically, it requires a long preparation time and is considered less efficient. To increase efficiency, the medical physics team in a hospital uses slab phantom as the calibration tool. Consequently, the correction factor is crucial to define the equivalence of the absorbed doses resulted from slab phantom. The absorbed dose measurement was performed according to the IAEA TRS-398 dosimetry protocol with a cylindrical ionization chamber detector for 6 MV photon beam and electron beams from Elekta Synergy Platform 154029 LINAC with 6 MeV, 8 MeV, 10 MeV, and 12 MeV energy variations. The field size for slab and water phantom is 30 cm x 30 cm x 30 cm. Based on the TRS-398 protocol, the correction factor of the slab phantom calculated based on absolute dosimetry for 6 MV photons beam, the electron beam of 6 MeV, 8 MeV, 10 MeV, and 12 MeV are 1.0018; 0.9995; 0.9979; 1.0041 and 1.0068, respectively. As a result, the absorbed dose radiation measured by the calibrated slab phantom using the resulted correction factor has an equivalent amount to the water phantom.
Novel Strategies to Increase COVID-19 Testing Among Underserved and Vulnerable Populations in West Virginia
Authors: Whanger Stacey , Davis Sherri K. , Kemper Emily , Heath-Granger Jada , Hodder Sally L.
Published: October 2022

This project addressed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing barriers in rural West Virginia by providing testing enhancements that included (1) a flexible testing staff, (2) mobile testing, (3) essential supplies, and (4) specialized testing in communities of color. A total of 142 775 polymerase chain reaction tests were performed from December 2021 through February 2022; positivity rates were 21% and 17% in clinics and mobile testing venues, respectively. The project results showed that, within a statewide network of health care clinics, administrators quickly identified and distributed enhancements and thus reduced testing barriers. (Am J Public Health. 2022;112(S9):S892–S895. https://doi.org/10.2105/AJPH.2022.307004 )
Development of an At-Home COVID-19 Test Results–Reporting System for a School District Primarily Serving Underrepresented Minority Groups, San Diego, CA, 2021–2022
Authors: McDaniels-Davidson Corinne , Arechiga-Romero Marisela , Snyder Tom , Chris Nicole , Sturgis Kanako , Moore Vernon , Bravo Rebecca , Famania-Martinez Lynnette , Oren Eyal , Kiene Susan M.
Published: October 2022

School-sponsored at-home COVID-19 testing benefits users, school administrators, and surveillance efforts, although reporting results remains challenging. Users require simple systems with tailored posttest guidance, and administrators need timely positive test information. We built a system to serve these needs and to collect data for our Rapid Acceleration of Diagnostics-Underserved Populations Return to School Program study in San Diego County, California, from October 2021 through January 2022. We describe this system and our participant outreach strategies and outline a replicable model for at-home results reporting. (Am J Public Health. 2022;112(S9):S883–S886. https://doi.org/10.2105/AJPH.2022.307073 )
Peran self-efficacy dalam meningkatkan minat berwirausaha women entrepreneur yang dimediasi oleh pengetahuan kewirausahaan
Authors: Hartini Hartini , Wardhana Aditya , Normiyati Normiyati , Sulaiman Syarifuddin
Published: October 2022

This study was conducted to analyze the effect of entrepreneurial knowledge on self-efficacy; the effect of entrepreneurial knowledge on entrepreneurial intention; the effect of self-efficacy on entrepreneurial intention; the effect of entrepreneurial knowledge on entrepreneurial intention through self-efficacy. Using a quantitative research with an explanatory research survey method. Data analysis using path analysis through modeling of the Structural Equation Modeling (SEM) with AMOS. The data were collected through questionnaires to 120 women of fashion entrepreneurs in Makassar City, South Sulawesi. The results showed that entrepreneurial knowledge has a positive and significant effect on self-efficacy; entrepreneurial knowledge has a positive and significant effect on entrepreneurial intention; self-efficacy has a positive and significant effect on entrepreneurial intention; self-efficacy does not mediate the effect of entrepreneurial knowledge on entrepreneurial intention. The results of this study become a reference for women in conducting entrepreneurial activities and recognizing the influential aspects of entrepreneurship.
Analysis of the factors of intention to use QRIS for MSMEs in Semarang City’s traditional market
Authors: Nurhapsari Risma , Sholihah Erlinda
Published: October 2022

Quick Response Indonesian Standard (QRIS) is the standardization of QR codes as a technology for payment systems established by Bank Indonesia on January 1, 2020. This standardization was formed to provide an easier and more efficient cashless payment system, especially for MSMEs. This study targets to analyze factors, namely product knowledge, perceived usefulness, perceived ease of use, and perceived risk of the intention of using QRIS in Traditional Market MSMEs in Semarang City. The model in this study was developed from the Technology Acceptance Model (TAM) framework and adapted to the context of MSMEs in Indonesia. This research uses an associative quantitative approach. The population in this study was traders in seven traditional markets in the Semarang City area. As empirical data was collected through a questionnaire involving 105 respondents from traders in the traditional market of Semarang City, then analyzed with SEM-PLS analysis techniques with SmartPLS software. The results showed that product knowledge, perceived usefulness, and perceived ease of use positively and significantly affected the intention of using QRIS. Then, perceived risk negatively and significantly affects the intention of using QRIS
Accrual-based vs cash-based accounting in affecting underpricing phenomenon: Evidence from emerging country
Authors: Soesetio Yuli , Siswanto Ely , Istanti Lulu Nurul , Subagyo Subagyo
Published: October 2022

Until now, more than 80 percent of shares are underpriced at every IPO event around the world, making it a phenomenon and a big unsolved puzzle, so it is still interesting and relevant to research, especially in emerging countries. This study aims to reveal the impact of profitability information based on accrual and cash on the phenomenon of underpricing on the Indonesia Stock Exchange (IDX). The sample used was firms that conducted IPOs on the IDX from 1994-2020 that had met the sample criteria of 475 firms using the purposive sampling method. Furthermore, the collected cross-section data were analyzed using ordinary least square (OLS) regression. The study concluded that only accrual-based profitability information consistently affects underpricing. These results also support the argument that the use of the accrual-based is better than the cash-based to predict underpricing. This study implies that IPO firms to pay more attention to, strengthen, and maintain their 'earnings' so that investors are more confident regarding the firm's future business continuity. In addition, investors are more detailed in using information from the prospectuses of large firms.
Effectiveness of structural equation modeling to measure hotel customer satisfaction
Authors: Normi Siti , Panjaitan Mangasa
Published: October 2022

Although some studies on gauging hotel guests' levels of satisfaction have been published in several research findings, structural equation modeling's efficacy in Indonesia is still rarely investigated. The study's objective is to assess hotel patron satisfaction utilizing an electronic system for guest reviews that is centered on online and Internet technology. The research's data came from 500 hotel guests staying at two five-star full-service hotels in Medan, North Sumatra. To accomplish this goal, the study used structural equation modeling to uncover the inherent link between consumer assessments of hotel services and amenities on one side and perceived usefulness, contentment, and their intention to return and refer customers on the other side. The findings demonstrate the clear correlations between value, contentment, desire to return and suggest as well as customer ratings of employee quality of service, guest bedroom quality, safety, and service disruption. Additionally, it should be highlighted that major mediating influences had an impact on how well-liked the hotel's amenities and employees provided service to guests. Through the use of web-based technologies, the research offered several recommendations for improving guest satisfaction with hotel operations. The results of this study could contribute to hotel management concentrating on the elements of the experiences of their guests that are the most important factors for boosting the level of satisfaction.
STRONTIUM ISOTOPE STRATIGRAPHY REVEALS 100 KY-SCALE CONDENSATION, BEVELING, AND INTERNAL SHINGLING OF TRANSGRESSIVE SHELL BEDS IN THE MARYLAND MIOCENE
Authors: ZIMMT JOSHUA B. , KIDWELL SUSAN M. , LOCKWOOD ROWAN , THIRLWALL MATTHEW
Published: October 2022

Condensed transgressive shell beds, rich in paleobiological information, are common in the Phanerozoic stratigraphic record, but their interpretation is complicated by the uncertain amount of time that each deposit represents. Miocene strata exposed in the Calvert Cliffs (Maryland, USA) are known for a series of regionally extensive, densely packed, meters-thick shell beds that serve as global exemplars of shallow-water condensation during marine transgression and onlap. Applying Sr isotope stratigraphy to calcitic scallops from the base and top of the oldest of these beds (Shattuck Zone 10), we demonstrate that its most densely fossiliferous part accumulated over the interval of 16.60–15.95 Ma, reflecting approximately 0.65 ±0.20 Myr of skeletal accumulation within the Miocene Climatic Optimum, with a likely 0.15 Myr-scale of time averaging per each firmground-bounded subunit. Both of these estimates are an order of magnitude longer than previous best estimates based on radiocarbon-dated Holocene analogs. Sr isotopes confirm subtle low-angle erosional beveling of the main body of Zone 10, truncating 0.3-Myr of record in updip sections, and demonstrate that a down-dip wedge of less shelly sand is an entirely younger (by ∼ 0.5 Myr) interleaved body. This condensation, beveling, and inter-shingling within Zone 10 quantified here sets a precedent for the magnitude of lateral and vertical temporal variability within condensed transgressive deposits, relevant to paleobiologic and other geohistorical analysis, and justifies the interpretation of comparably complex temporal fabrics based upon similar physical stratigraphic features found elsewhere in this and other very thin stratigraphic records.
Primary Extracranial Meningioma Mimicking Musculoskeletal Malignancy: A Case Report
Authors: Han Seungju , Lee Won Hee
Published: October 2022

Primary extracranial meningioma (PEM) is a very rare disease that arises outside the dural covering of the brain or spinal cord. It is essentially an extracranial tumor and can mimic musculoskeletal malignancies. A 74-year-old woman presented with a mass on the right frontotemporal scalp that had been present for 2 years. Magnetic resonance imaging revealed osteolysis in the right frontal, temporal, and sphenoid bone and involvement of the right temporalis muscle, mimicking a musculoskeletal malignancy. The mass was resected, and the confirmed histological diagnosis was primary extracranial meningothelial meningioma (World Health Organization grade I). The patient was discharged without complications, and no evidence of tumor recurrence was apparent 48 months after surgery. This case supports complete surgical excision without adjuvant therapy as the modality of choice for PEM since meningioma is radioresistant and recurrence is very rare after adequate surgical resection.
Structural elucidation of polydopamine facilitated by ionic liquid solvation
Authors: Singh Abhishek , Mason Thomas , Lu Zhenzhen , Hill A. , Pas Steven , Teo Boon Mian , Freeman Benny , Pas Ekaterina
Published: October 2022

Minimal understanding of the formation mechanism and structure of polydopamine (pDA) and its natural analogues, eumelanin impedes the practical application of these versatile polymers and limits our knowledge of the origin of melanoma.1–8 The lack of conclusive structural evidence stems from the insolubility of these materials, which has spawned significantly diverse suggestions of pDA’s structure in the literature.9,10 We discovered that pDA is soluble in certain ionic liquids. Using these ionic liquids (ILs) as solvents, we present an experimental methodology to solvate pDA, enabling us to identify pDA’s chemical structure. The resolved pDA structure consists of self-assembled supramolecular aggregates that contribute to the increasing complexity of the polymer. The underlying molecular energetics of pDA solvation and a macroscopic picture of the disruption of the aggregates using IL solvents have been investigated, along with studies of the aggregation mechanism in water.
Upregulation of CHAC1 promotes bladder inflammation and predicts adverse prognosis in Bladder Urothelial Carcinoma
Authors: Yu Xudong , Liu Ruijia , Wang Xuyun , Zhang Yaosheng
Published: October 2022

Background
CHAC1 is a newly identified endoplasmic reticulum-inducible gene that is aberrantly expressed in a variety of cancers, but its function and mechanism are unclear. The aim of this study was to investigate the role of CHAC1 in Bladder Urothelial Carcinoma (BLCA).
Methods
All original data of CHAC1 was collected from the public databases including The Cancer Genome Atlas, Human Protein Atlas, and further analyzed by R (version 3.6.3). The correlations between CHAC1 and tumor immune characteristics were analyzed via the TIMER and TISIDB databases.
Results
The CHAC1 mRNA and protein expression levels were both higher in BLCA tissues compared with normal bladder tissues in the public databases CHAC1 expression was upregulated in BLCA, which had a clinical diagnostic value and was in correlation with poor prognosis. CHAC1 mRNA expression was negatively correlated with CHAC1 methylation levels. With enrichment analysis, we found that CHAC1 could affect the development of BLCA by regulating the glutathione metabolic and biosynthetic process, cellular modified amino acid biosynthetic process and Ferroptosis signaling pathways. Further analysis showed that CHAC1 expression was positively associated with macrophages, T-related cells, B cells, dendritic cells, and NK cells. In addition, CHAC1 expression was also closely related to immunomodulators and methylation immunomodulators in BLCA.
Conclusion
The study demonstrated CHAC1 can accurately predict survival, reflect the immune microenvironment, and predict the effectiveness of immunotherapy among BLCA patients. The study suggested that CHAC1 could be a potential biomarker and therapeutic target to assess the prognosis and regulate the immune cells infiltration level of BLCA.
Diversity deconstrains component limitations in sensorimotor control
Authors: Nakahira Yorie , Liu Quanying , Sejnowski Terrence , Doyle John
Published: October 2022

Human sensorimotor control is remarkably fast and accurate at the system level despite severe speed-accuracy trade-offs (SATs) at the component level. The discrepancy between the contrasting SATs at these two levels is a paradox. Here we describe reaching experiments in which sensorimotor delays and quantization errors were manipulated to test their effects on reaching speed and accuracy as a surrogate for manipulating the biophysical properties. A mechanistic model was developed for how component SATs constrain sensorimotor control that is consistent with the experimental results and with Fitts' Law for reaching. The model and experiments suggest that diversity among components deconstrains their individual limitations in sensorimotor control. Such "diversity-enabled sweet spots" (DESSs) are ubiquitous in both engineering and biology, explaining why large heterogeneities exist in the components of artificial and biological systems and how both engineers and natural selection routinely evolve into systems with fast and accurate responses using imperfect components.
Hepatitis B Vaccine Uptake and Associated Factors among Adults in Northern Uganda: A community-based cross-sectional study
Authors: Aber Janet Okello , Bongomin Felix , Opio Stephen Lawoko , Ochola Emmanuel
Published: October 2022

Background Hepatitis B virus (HBV) infection is a global public health problem against which vaccination is recommended for all high-risk adults. HBV is highly endemic in Northern Uganda, however, there is a paucity of literature regarding HBV vaccine uptake and associated factors within the community in the region. In this study, we aimed to determine the level of HBV vaccine uptake and associated factors among adults in Gulu city, Uganda. Methods We conducted a community-based, cross-sectional study in Gulu city among eligible adults between March and May 2022. Data on HBV vaccination status and sociodemographic characteristics were collected using an interviewer-administered questionnaire. Full uptake of HBV vaccine was defined as receipt of all 3 recommended doses, and partial uptake for 1 or 2 doses. Multivariable logistic regression analysis was performed using STATA 16.0 to determine factors independently associated with HBV vaccine uptake. P < 0.05 was considered statistically significant. Results In total 360 participants were enrolled, of whom 212 (58.9%) were female, 183 (50.8%) were aged 30 years or younger, and 143 (39.7%) had attained tertiary education. Overall, 96 (26.7%) participants had full uptake of HBV vaccine and 73 (20.3%) had partial uptake. Factors that were statistically significantly associated with full uptake of HBV vaccine were; Good knowledge regarding HBV transmission (adjusted odds ratio (aOR) = 1.9, 95% Confidence Interval (CI) = 1.03 — 3.46, p = 0.040) and receiving health education on HBV vaccination (aOR = 4.4, 95% CI = 2.3 — 8.4, p < 0.001). Conclusions There is a low uptake of HBV vaccine in Gulu city. The Uganda Ministry of Health should correct misconceptions, create awareness of the severity of HBV infection through health education regarding HBV infection within the community in Gulu City; and set mechanisms to follow-up clients due for next HBV vaccination.
Natural and pathological aging distinctively impact the pheromone detection system and social behavior
Authors: Montes Adrian Portales , Chamero Pablo , Jurado Sandra
Published: October 2022

Background: Normal aging and many age-related disorders such as Alzheimer´s disease cause deficits in olfaction, however it is currently unknown how natural and pathological aging impact the detection of social odors which might contribute to the impoverishment of social behavior at old age further worsening overall health. Here, we investigated the effect of aging in the recognition of social cues and the display of social behavior.
Methods: Social and non-social scents were employed to discern the specific impact of aging and neurodegeneration in social odor perception. Odor-evoked sniffing tests were employed to estimate the exploration time in response to social and non-social odors in naturally aged animals (up to 2-year-old senescent mice) and an animal model of Alzheimer´s disease (APP/PS1). Social habituation-dishabituation tests were adapted to determine short- and long-term social discrimination, the effect of previous experience in social recognition and potential disruptions of self-awareness. Sociability and social novelty were analyzed by a three chamber test. Mature (OMP) and proliferating (Sox2, PCNA) neurons in the vomeronasal organ were analyzed by immunostaining and stereology during healthy and pathological aging.
Results: Our findings indicate that aging distinctively disrupts the processing of social olfactory cues decreasing social odor exploration, discrimination and habituation in both wild type senescent (2-year-old) mice and in 1-year-old double mutant model of Alzheimer´s disease (APP/PS1). Furthermore, social novelty was diminished in 1-year-old APP/PS1 mice, indicating that alterations in the processing of social cues are accelerated during pathological aging. Analysis of the vomeronasal organ, the main gateway to pheromone-encoded information, indicated that natural and pathological aging distinctively affect the neurogenic ability of the vomeronasal sensory epithelium. Whereas cell proliferation remained majorly preserved in 1-year-old APP/PS1 mice, naturally aged animals exhibited significant deficiencies in the number of mature, proliferative and progenitor cells.
Conclusions: This study reveals fundamental differences in the cellular processes by which natural and pathological aging disrupt the exploration of social information and social behavior.
Effects of grazing on the ecosystems multifunctionality of montane meadow-grassland, the northern slope of Tianshan Mountains, China
Authors: Jiang Kangwei , Zhang Qingqing , Wang Yafei , Li Hong , Yang Yongqiang , Reyimu Tursunnay
Published: October 2022

Ecosystem multifunctionality (EMF) plays an irreplaceable role in maintaining ecological balance and ensuring human survival and development. However, few studies have focused on the effects of different grazing intensities on EMF, and little is known about the changes in the function of multiple ecosystems at different grazing intensities. The paper uses research methods such as plant community survey and high-throughput sequencing technology to study the grassland EMF on the northern slope of Tianshan Mountains in China. We use the mean value method to calculate the EMF and explore the effects of no grazing (CK), light grazing (LG) and heavy grazing (HG) on grassland EMF. Results showed that HG significantly improved moisture regulation (MR) function (p < 0.05), and decreased soil fertility (SF) (p > 0.05), soil carbon storage (SCS) (p > 0.05), nutrient conversion and cycling (NC) (p > 0.05), grassland productivity (GP) function (p < 0.05) and EMF (p < 0.05). The EMF index of the grassland ecosystem under grazing conditions ranges from 0.3328–0.6018. GP, SCS and NC functions have the highest contribution to EMF under CK, LG and HG conditions, respectively. Under grazing conditions, EMF showed a cooperative relationship with SF, SCS and GP, and the correlation coefficient (r) value was between 0.62–0.76 (P < 0.05). At the same time, EMF and grassland water MR showed a trade-offs relationship (r = 0.68, P < 0.05). The results of structural equation models showed that grazing have a significant effect on EMF directly, and indirectly through soil fungal diversity. Therefore, reasonable reduction of grazing intensity is the most effective management approach to maintain ecosystem function. At the same time, grazing plays a key role in maintaining EMF by regulating both above- and below-ground ecosystem functions, primarily through soil fungal diversity. This study sheds light on the EMF response to grazing intensity in montane grasslands, and provides a theoretical basis for restoring degraded grasslands and sustainable ecosystem development.
Single-Cell RNA sequencing reveals altered microenvironment and pro-tumoral effects of TLE4 within invasive somatotroph adenoma
Authors: LOU meiqing , xu houshi , zhang anke , fang chaoyou , liu yibo , wang xiaoyu , shao anwen , chen sheng , wang kaikai , hong yuan , zhang jianmin
Published: October 2022

Background: Invasive somatotroph adenoma, a dominant subtype of pituitary adenoma (PA), is considered a clinical challenge with limited treatments other than surgery. Single-cell transcriptome analysis provides the opportunity to characterize the cellular composition of the tumor microenvironment (TME) and elucidate the potential origin of PA cells and the mechanisms of tumor progression.
Methods: We performed high-resolution single-cell RNA sequencing of 7,291 single cells obtained from invasive and noninvasive somatotroph adenomas. The alteration of the TME and the evolution of invasive PA cells were investigated in depth and verified in vivo and in vitro.
Results: We constructed a single-cell transcriptional atlas and explored cell-cell interactions in the TME. The evolution and progression of invasive somatotroph adenoma were depicted from a single-cell perspective, and the key gene TLE4 was selected as the study focus. It was demonstrated by both in vivo and in vitro studies that upregulation of TLE4 in PA cells significantly enhanced tumor growth and invasive features.
Additionally, according to analysis of human PA samples, high TLE4 expression was associated with larger tumor size and greater invasion.
Conclusion: We described the alterations and intracellular interactions in the TME of PAs for the first time. Moreover, we revealed that TLE4 expression in PA cells is associated with PA invasion and may serve as a potential diagnostic marker or therapeutic target for PA.
Effectiveness of Coronavac and ChAdOx1 COVID-19 vaccines against severe illness in Thailand: A retrospective cohort study
Authors: Promlek Thanyarat , Hansirisathit Tonsan , Kunno Jadsada , Thanunchai Maytawan
Published: October 2022

Background
Two primary vaccines for coronavirus disease 2019 (COVID-19) have been rolled out in the mass vaccination campaign that started simultaneously with the spread of the delta variant. This study aimed to explore vaccines’ effect on reducing infectiousness and disease severity.
Methods
This retrospective cohort study was conducted in Thai patients aged ≥ 18 years who received one and two doses of either CoronaVac or ChAdOx1 nCoV-19 and a booster vaccine and confirmed COVID-19 positive by reverse-transcriptase polymerase chain reaction. To determine the effect of vaccines on infectiousness and occurrence of severe COVID-19-related outcomes, the Ct values and number of severe cases were compared between vaccinated and unvaccinated people, among vaccine regimens.
Results
No difference in Ct values was found between the vaccinated and unvaccinated groups. To reduce the occurrence of severe illness, the vaccine effectiveness (VE) of a vaccine booster and two-dose CoranaVac provided 100% protection, followed by two-dose ChAdOx1 nCoV-19 (84.7%, 95% CI 18.2–98.0), whereas one-dose regimen of either CoronaVac or ChAdOx1 nCoV-19 had VE of < 71.6%.
Conclusion
Vaccinations with two primary vaccines could not reduce viral load in patients with COVID-19, but could prevent severe illness.
The inhibition mechanism of Lactobacillus fermented whey protein and blueberry juice mixture system against Escherichia coli during storage
Authors: Qian Yu , Gui-bing Lu , Wen-qiong Wang , Cong-cong Tang
Published: October 2022

This study aimed to identify the antimicrobial effect and mechanism of whey protein and blueberry juice mixture system using lactobacillus fermentation against Escherichia coli during storage. The whey protein and blueberry juice mixture systems using Lactobacillus casei M54, Lactobacillus plantarum 67, Streptococcus thermophiles 99 or Lactobacillus bulgaricus 134 had different antibacterial activity against E. coli during storage. The antimicrobial activity of whey protein and blueberry juice mixture fermentation systems was the highest with inhibition zone diameter of about 230 mm compared with the whey protein or blueberry juice fermentation alone. There was no viable E. coli cells after 7 h with the treatment of whey protein and blueberry juice mixture systems by survival curve analysis. The inhibitory mechanism analysis showed that the release of alkaline phosphatase (AKP), electrical conductivity, protein content, aspartic acid transaminase (AST), alanine aminotransferase (ALT) and pyruvic acid content on E. coli had increased. These results demonstrated that these mixture fermentation systems especially containing blueberry could inhibit the growth of E. coli and even cause cells death by destroying the cell the membrane and cell wall.