bluuebunny/crossref_metadata_2025 huggingface dataset:
Rituximab/bendamustine/cytarabine for transplant‐eligible patients with mantle cell lymphoma: A retrospective study
Authors: Shimizu Yuki , Kaji Daisuke , Watanabe Otoya , Yamaguchi Kyosuke , Kageyama Kosei , Taya Yuki , Nishida Aya , Ishiwata Kazuya , Takagi Shinsuke , Yamamoto Hisashi , Mori Yuki‐Asano , Wake Atsushi , Uchida Naoyuki , Taniguchi Shuichi , Yamamoto Go
Published: May 2023

Background

Mantle cell lymphoma is considered an aggressive B‐cell lymphoma. The optimal induction regimen remains controversial as no randomized controlled trial has compared the efficacy of different induction therapies.

Method

Herein, we performed a retrospective analysis of the clinical characteristics of 10 patients who received induction treatment consisting of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R‐CHOP) and rituximab, bendamustine, and cytarabine (R‐BAC) at Toranomon Hospital between November 2016 and February 2022.

Result

Although one patient discontinued R‐BAC therapy due to a rash, the other nine completed the scheduled chemotherapy. All patients achieved complete response, underwent high‐dose chemotherapy and autologous stem cell transplantation, and maintained complete remission with a median follow‐up of 15 months. Hematological adverse events (AEs) occurred in all patients; however, none developed documented infection. There were also no fatal non‐hematological AEs specific to R‐BAC.

Conclusion

R‐CHOP/R‐BAC may be a good induction therapy for transplant‐eligible patients with mantle cell lymphoma.
Foldamer Nanotubes Mediated Label‐Free Detection of Protein‐Small Molecule Interactions
Authors: Puneeth Kumar DRGKoppalu R. , Manzoor Bhat Zahid , Dey Sanjit , Roy Souvik , Panda Mahapatra Souvik , Pahan Saikat , Thotiyl Musthafa Ottakam , Gopi Hosahudya N.
Published: May 2023

Development of miniaturized lab‐on‐chip devices for the detection of rapid and specific small molecule‐protein binding interactions at very low concentrations holds significant importance in drug discovery and biomedical applications. Here, the label‐free detection of small molecule‐protein interactions is reported on the surface functionalizable nanotubes of α,γ‐hybrid peptide helical foldamers using nanoscale capacitance and impedance spectroscopy. The 12‐helix conformation of the α,γ‐hybrid peptide observed in the single crystals, self‐assembled into nanotubes in an aqueous environment with exposed cysteine thiols for small molecule conjugation. The binding of streptavidin to the covalently linked biotin on the surface of nanotubes was detected at the picomolar concentrations. No change in the capacitance and impedance were observed in the absence of either immobilized biotin or protein streptavidin. The functionalizable hybrid peptide nanotubes reported here pave the way for the label‐free detection of various small molecule protein interactions at very low concentrations.
Helical Self‐Assembly and Fe3+ Detection of V‐Shaped AIE‐Active Chiral Tetraphenylbutadiene‐Based Polyamides**
Authors: Zhao Zixuan , Zhang Lulu , Zhao Ying , Li Yanji , Shi Jianbing , Zhi Junge , Dong Yuping
Published: May 2023

Chiral aggregation‐induced emission (AIE) molecules have drawn attention for their helical self‐assembly and special optical properties. The helical self‐assembly of AIE‐active chiral non‐linear main‐chain polymers can produce some desired optical features. In this work, a series of V‐shaped chiral AIE‐active polyamides P1‐C3, P1‐C6, P1‐C12 and linear P2‐C3, P2‐C6, bearing n‐propyl/hexyl/dodecyl side‐chains, based on tetraphenylbutadiene (TPB), were prepared. All target main‐chain polymers exhibit distinct AIE characteristics. The polymer P1‐C6 with moderate length alkyl chains shows better AIE properties. The V‐shaped main‐chains and the chiral induction of (1R,2R)‐(+)‐1,2‐cyclohexanediamine in each repeating unit promote the polymer chains display helical conformation, and multiple helical polymer chains induce nano‐fibers helicity when the polymer chains aggregate and self‐assemble in THF/H2O mixtures. Simultaneously, the helical conformation polymer chains and helical nano‐fibers cause P1‐C6 produce strong circular dichroism (CD) signals with positive Cotton effect. Moreover, P1‐C6 could also occur fluorescence quenching response to Fe3+ selectively with a low detection limit of 3.48 μmol/L.
Sugar‐Bridged Fullerene Dumbbells and Their Interaction with the [10]Cycloparaphenylene Nanoring
Authors: Jakšić Jovana , Solymosi Iris , Hirsch Andreas , Pérez‐Ojeda M. Eugenia , Mitrović Aleksandra , Maslak Veselin
Published: May 2023

The synthesis and characterization of four dumbbell‐shaped fullerene molecules connected by isosorbide and isomannide moieties is presented. Additionally, their electrochemical behavior and their ability to form complexes with [10]cycloparaphenylene ([10]CPP) were investigated. The cyclic voltammetry (CV) results of the fullerene dumbbells demonstrate a high electron affinity, indicating their strong interaction with electron‐donating counterparts such as carbon nanorings, which possess complementary charge and shape properties. To study the thermodynamic and kinetic parameters of complexation, isothermal titration calorimetry (ITC) was employed. NMR titration experiments provided further insights into the binding stoichiometries. Two distinct approaches were utilized to create bridged structures: one based on cyclopropane and the other based on furan. Regardless of the type of linker used, all derivatives formed conventional 2 : 1 complexes denoted as [10]CPP2⊃C60derivative. However, the methano‐dumbbell molecules exhibited distinct binding behavior, resulting in the formation of mono‐ and bis‐pseudorotaxanes, as well as oligomers (polymers). The formation of linear polymers holds significant potential for applications in solar energy conversion processes.
Long‐Lived Charge Separated States in Anthraquinone‐Phenothiazine Dyads: Synthesis and Study of the Photophysical Property by Using Transient Optical and Magnetic Resonance Spectroscopies
Authors: Wang Haiqing , Sukhanov Andrey A. , Iagatti Alessandro , Bussotti Laura , Zhao Xiaoyu , Zhao Jianzhang , Voronkova Violeta K. , Di Donato Mariangela
Published: May 2023

In order to obtain long‐lived charge separated (CS) states in electron donor‐acceptor dyads, herein we prepared a series of anthraquinone (AQ)‐phenothiazine (PTZ) dyads, with adamantane as the linker. UV–vis absorption spectra show negligible electronic interaction between the AQ and PTZ units at ground state, yet charge transfer (CT) emission bands were observed. Nanosecond transient absorption shows that the 3AQ state is populated upon photoexcitation for AQ‐PTZ in cyclohexane (CHX), but in acetonitrile (ACN) a 3CS state is formed. Similar results were observed for AQ‐PTZ‐M. The 3CS state lifetimes were determined as 0.52 μs and 0.49 μs, respectively. Upon oxidation of the PTZ unit, the 3AQ state was observed in both polar and non‐polar solvents. For AQ‐PTZ, femtosecond transient absorption spectra show fast formation of the 3AQ state in all solvents, with no charge separation in CHX, while formation of the 3CS state takes 106 ps in ACN. For AQ‐PTZ‐M, a 3CS state is formed in CHX within 241 ps. Time‐resolved electron paramagnetic resonance (TREPR) spectra show that a radical ion pair with electron exchange energy of |2 J|≥5.68 mT was observed for AQ‐PTZ and AQ‐PTZ‐M, whereas in the dyads with the PTZ unit oxidized, only the 3AQ state was observed.
Capture and Removal of Iodine by a Fluorinated Leaning Pillar[6]arene with Host–Guest Interactions
Authors: Shi Bingbing , Li Weichun , Qin Peng , Wei Tai‐Bao , Qu Wen‐Juan , Liu Yuezhou , Lin Qi
Published: May 2023

Volatile radioactive pollutants are posing great challenges to global environment. Volatile radioactive iodine, which is one of the primary environmental pollutants from nuclear power plants, spreads rapidly in water and air and increases risk to human health. Therefore, the research for appropriate adsorbents to capture iodine with long‐term storage is crucial. In this study, we report that easily obtained fluorinated leaning pillar[6]areneFP6is a new adsorbent for iodine capture with robust moisture and thermal stability. Crystalline solidFP6solid can capture not only volatile iodine in the air but also iodine dissolved in aqueous solutions with fast adsorption speed and high up‐take capacity. Host–guest interactions betweenFP6and iodine indicates that iodine molecule is threaded into the cavity of the cyclic hostFP6to form a host‐guest complex driven by C−F ⋅⋅⋅ I halogen bonding interactions. Moreover, the regeneration ofFP6is simple and efficient, and it can be regenerated at least five times by simply heating under vacuum at 120 °C for 3 hours without losing iodine capture capacity. The excellent iodine pollutant removal ability demonstrates the promise ofFP6for pollutant treatment.
BiVO4 Heterojunctions as Efficient Photoanodes for Photoelectrochemical Water Oxidation
Authors: He Dongqing , Wang Qi , Zhang Weijun , Liu Xiaodong , Cui Xianghong
Published: May 2023

Photoelectrochemical (PEC) water splitting has attracted strong interest as sustainable technology by converting solar energy into hydrogen. The semiconductor photoelectrodes play an important role to increase the solar‐to‐hydrogen conversion efficiency. Bismuth vanadate (BiVO4) is an excellent candidate as a photoanode material for PEC water oxidation because of its visible light absorption, suitable band edge location, high stability and low cost. However, BiVO4 alone may undergo short carrier diffusion length, rapid recombination of photo‐induced charge carriers and photocorrosion. The heterojunction strategy established by combining two or more materials has provided an outstanding technique to address these issues. This Review focuses on recent important works with respect to BiVO4 heterojunction photoanodes for PEC water oxidation reactions, including interface junction and surface functional junction formation. Additionally, challenges faced and prospects for future research on BiVO4 heterojunction photoanodes in the field of solar‐to‐hydrogen conversion are proposed.
Insights into the Response Differences of Ultrasonic Rolled A3 Carbon Steels and 316L Stainless Steels to Scale and Wax Precipitation Behavior
Authors: Xue Juanqin , Ren Kang , Tao Guanyu , Tang Changbin , Guo Yinyin , Yu Yongqi
Published: May 2023

In this work, the antiscaling and antiwaxing properties are evaluated by surface roughness testing, water contact angle measurements, scale and wax deposition testing, and potentiodynamic polarization analysis, respectively. The morphologies and microstructures of the samples before and after ultrasonic surface rolling process (USRP) are analyzed by scanning electron microscopy and optical microscopy, respectively. The results show that for 316L stainless steel after USRP, its surface roughness and surface energy decrease by 97% and 27%, respectively, and the average scale amount is decreased by 73% and antiwaxing rate is up to 63%. In contrast, for the A3 steel after USRP, the average amount of scale and wax deposition increases due to the enhanced atomic activity of the surface layer and surface energy although its reduced surface roughness. It is found that the lower surface energy is the primary factor for improving the antiscaling and antiwaxing performance. A second factor may be related to the smooth surface and superior corrosion resistance.
Corporate social responsibility and technological perspectives in healthcare: An exploratory analysis of the evolution of the anti‐corruption system through multiple case studies
Authors: Campra Maura , Esposito Paolo , Brescia Valerio
Published: May 2023

Corruption is one of the main variables to be considered in corporate social responsibility (CSR) to guarantee the well‐being of society in the long term. Information technology (IT) is able to reduce this phenomenon of corruption. However, no practical studies highlight the real effect on health organisations. This study ascertains the impact of a pilot project to prevent corruption and the introduction of new dedicated technologies in the healthcare organisation. It uses the association of institutional theory, information and communications technology (ICT), and new technologies to cover the gap and highlight the effect of an anti‐corruption pilot project of International Transparency Italia in the healthcare sector. A longitudinal approach‐based interventionist approach, coding of semi‐structured open interviews and corporate anti‐corruption plans using AltasIT from the 13 Health Organisations that joined the pilot project over a long term reveals that a positive effect spreads by mimetic approach within organisations. The study has detected open‐access databases, changes in personnel and procurement management approach, information dissemination, citizen involvement and whistleblowing support change through technologies. More specifically, it examines the evolution of the anti‐corruption system and the stakeholders' perceptions in healthcare organisations as a new form of social responsibility. To the best of our knowledge, this study is the only one that applies this perspective to the analysis of the anti‐corruption process through CSR currently underway in healthcare institutions worldwide.
Environmental backgrounds of CEOs and corporate environmental management information disclosure: The mediating effects of financing constraints and media attention
Authors: Zhu Changchun , Li Na , Ma Jing
Published: May 2023

In the context of the global economy's green and low‐carbon development, companies are paying increasing attention to environmental management. This study compiles statistics on Chinese listed firms from 2010 to 2020 and examines the influence of CEOs' environmental background on corporate environmental management information disclosure based on imprinting theory. It found that CEOs with environmental backgrounds are more willing to disclose corporate environmental management information, and the level of disclosure is high. By attracting media attention and reducing the company's financing constraints, CEOs with an environmental background can enhance the level of corporate environmental management information disclosure, according to the analysis of the impact mechanism. Further research revealed that CEO environmental background promoted corporate environmental management information disclosure more significantly in state‐owned and heavily polluting enterprises.
Epstein–Barr virus and multiple sclerosis: moving from questions of association to questions of mechanism
Authors: Thomas Olivia G , Rickinson Alan , Palendira Umaimainthan
Published: May 2023

The link between Epstein–Barr virus (EBV) and multiple sclerosis (MS) has puzzled researchers since it was first discovered over 40 years ago. Until that point, EBV was primarily viewed as a cancer‐causing agent, but the culmination of evidence now shows that EBV has a pivotal role in development of MS. Early MS disease is characterised by episodic neuroinflammation and focal lesions in the central nervous system (CNS) that over time develop into progressive neurodegeneration and disability. Risk of MS is vanishingly low in EBV seronegative individuals, history of infectious mononucleosis (acute symptomatic primary infection with EBV) significantly increases risk and elevated antibody titres directed against EBV antigens are well‐characterised in patients. However, the underlying mechanism – or mechanisms – responsible for this interplay remains to be fully elucidated; how does EBV‐induced immune dysregulation either trigger or drive MS in susceptible individuals? Furthermore, deep understanding of virological and immunological events during primary infection and long‐term persistence in B cells will help to answer the many questions that remain regarding MS pathogenesis. This review discusses the current evidence and mechanisms surrounding EBV and MS, which have important implications for the future of MS therapies and prevention.
Pre‐discharge and early post‐discharge management of patients hospitalized for acute heart failure: A scientific statement by the Heart Failure Association of the ESC
Authors: Metra Marco , Adamo Marianna , Tomasoni Daniela , Mebazaa Alexandre , Bayes‐Genis Antoni , Abdelhamid Magdy , Adamopoulos Stamatis , Anker Stefan D. , Bauersachs Johann , Belenkov Yuri , Böhm Michael , Gal Tuvia Ben , Butler Javed , Cohen‐Solal Alain , Filippatos Gerasimos , Gustafsson Finn , Hill Loreena , Jaarsma Tiny , Jankowska Ewa A. , Lainscak Mitja , Lopatin Yuri , Lund Lars H. , McDonagh Theresa , Milicic Davor , Moura Brenda , Mullens Wilfried , Piepoli Massimo , Polovina Marija , Ponikowski Piotr , Rakisheva Amina , Ristic Arsen , Savarese Gianluigi , Seferovic Petar , Sharma Rajan , Thum Thomas , Tocchetti Carlo G. , Van Linthout Sophie , Vitale Cristiana , Von Haehling Stephan , Volterrani Maurizio , Coats Andrew J.S. , Chioncel Ovidiu , Rosano Giuseppe
Published: May 2023

Acute heart failure is a major cause of urgent hospitalizations. These are followed by marked increases in death and rehospitalization rates, which then decline exponentially though they remain higher than in patients without a recent hospitalization. Therefore, optimal management of patients with acute heart failure before discharge and in the early post‐discharge phase is critical. First, it may prevent rehospitalizations through the early detection and effective treatment of residual or recurrent congestion, the main manifestation of decompensation. Second, initiation at pre‐discharge and titration to target doses in the early post‐discharge period, of guideline‐directed medical therapy may improve both short‐ and long‐term outcomes. Third, in chronic heart failure, medical treatment is often left unchanged, so the acute heart failure hospitalization presents an opportunity for implementation of therapy. The aim of this scientific statement by the Heart Failure Association of the European Society of Cardiology is to summarize recent findings that have implications for clinical management both in the pre‐discharge and the early post‐discharge phase after a hospitalization for acute heart failure.
A theoretical evaluation of the impact of the type of reaction on heat production and material losses in biomass piles
Authors: Dahlbom Sixten , Anerud Erik , Lönnermark Anders , Pushp Mohit
Published: May 2023

Self‐heating during storage of biomass in piles causes material losses, leads to emissions to air, and poses a risk of fire. There are different techniques to assess a biomass material's propensity for self‐heating, some of these are briefly reviewed. One of these techniques is isothermal calorimetry, which measures thermal power from materials and produces time‐resolved curves. A recently developed and published test standard, ISO 20049‐1:2020, describes how the self‐heating of pelletized biofuels can be determined by means of isothermal calorimetry and how thermal power and the total heat produced during the test should be measured by isothermal calorimetry. This paper supports interpretation of the result obtained by isothermal calorimetry; the mentioned standard provides examples of peak thermal power and total heat but does not provide any assistance on how the result from isothermal measurements should be interpreted or how the result from measurements on different samples could be compared. This paper addresses the impact of different types of reactions, peak thermal power, total heat released (heat of reaction), activation energy, heat conductivity, and pile size on the temperature development in a generic pile of biomass. This paper addresses important parameters when the result from isothermal calorimetry is evaluated. The most important parameter, with respect to temperature development in large piles, was found to be the total heat released. It was also proposed that safe storage times, that is, the time until a run‐away of the temperature in the pile, could be ranked based on the time to the peak thermal power.
Optimizing the effect of plant protease on different properties of analog cheese containing functional corn leachate
Authors: Araghi Farideh Eslambeig , Nodushan Rezvan Mousavi , Jafarpour Afshin , Moslehishad Maryam
Published: May 2023

Cheese is produced in different flavors, textures, and forms by coagulating the milk protein casein. This study investigated the possibility of producing analog cheese by using corn steep liquor with Withania coagulans extract (WCE) and adding Eryngium planum extract (EPE) and Origanum majorana extract (OME) as functional ingredients. Different physicochemical, microbial, texture, and sensory properties of the samples were evaluated. The results obtained for moisture factor, fat, ash, water content, L*, b*, firmness, overall form, Lactobacillus and overall acceptance of the effect of all three process variables, pH, and acidity show that only the effect of WCE and OME is significant. Also, the protein of the samples was significant only on WCE and EPE (p < .001). The results showed that an increase in the levels of independent variables resulted in an increase in the amount of moisture, ash, protein, Lactobacillus, and b* and a decrease in fat, syneresis, texture properties, coliform, and lightness. Evaluation of the overall acceptance showed that consumer acceptance increased with the increase in WCE, but it initially increased and then decreased with the increase in EPE and OME levels. Finally, the samples containing 1.5% WCE, 1% EPE, and 0.5% OME were chosen as the optimized ones.
Carbon assets and Bitcoin: Hedging roles in global stock markets during the tranquil and turbulent periods?
Authors: Jiang Wei , Zhang Yanyu
Published: May 2023

This paper studies time‐frequency connectedness among carbon assets, Bitcoin, and global stock markets by using the Diebold and Yilmaz method and the Baruník and Křehlík method, to investigate the hedging ability of carbon assets and Bitcoin in global stock markets. Our study finds that both carbon assets and Bitcoin play hedging roles in global stock markets. However, their strength of hedging is negatively correlated with the degree of economic uncertainty and tends to change in different frequency domains. We also show that carbon assets and Bitcoin can act as each other's hedging assets in a great majority of cases. Our results provide useful knowledge for investors to reduce risks and for regulators to regulate carbon assets and cryptocurrency speculation.
Audit of Ireland's first manual vacuum aspiration service
Authors: Corcoran A. , Hayes‐Ryan D. , O'Dwyer V. , Cooley S. , Ramphul M.
Published: May 2023

Introduction

Manual vacuum aspiration (MVA) is a safe and effective alternative option for the management of first‐trimester miscarriage, termination of pregnancy, or retained pregnancy tissue. Ireland's first MVA clinic was set up in the Rotunda Hospital in April 2020.

Objective

To identify the number of women who have undergone MVA since establishing our service, to assess the efficacy and safety of MVA in that service, and to develop local Irish studies that further support the safety of MVA, adding to the international body of evidence.

Methods

With the approval and assistance of the Clinical Audit Committee, we obtained a log of all patients who underwent MVA in the first 18 months of the service. We performed a retrospective electronic chart review using Maternal and Newborn Clinical Management System. We collected the data and preformed a descriptive analysis.

Results

In total, 86 women underwent MVA, 85 (98.8%) of which were successfully completed. There were no immediate procedural complications, inter‐hospital transfers, or emergency electric vacuum aspiration (EVA) required. We obtained an incomplete evacuation rate of 4.7% (n = 4).

Conclusion

We have demonstrated that the MVA service in the Rotunda Hospital is a safe, effective management option with advantages for both the patient and the healthcare system. We recommend consideration for provision of funding and resources to enable expansion of this service nationally in order to give women greater autonomy of choice in the management of early pregnancy complications and termination of pregnancy.
Disentangling unique and consensual group norm perceptions: A study with ethnic majority students
Authors: Thijs Jochem , Wiemers Samira
Published: May 2023

The influence of group norms is often tested via people's norm perceptions. Yet, people's group norm perceptions can be inaccurate, which raises the question to what extent effects of perceived norms indicate real group influence. The present study sought to obtain a better understanding of the value of group norm perceptions in social influence research. We used (longitudinal) data collected in 51 primary school classrooms in the Netherlands (Grades 3–6) and examined how majority of children's (N = 779; aged 7–13 years) perceptions of the anti‐prejudice norm of their classroom peer group affected their ethnic outgroup attitudes both concurrently and over time. We divided these perceptions into a consensual and a unique part and investigated the moderating role of ingroup identification. Results showed concurrent effects of the consensual and unique norm perceptions, but a longitudinal effect of the consensual perceptions only. Classroom identification increased the concurrent effect of unique norm perceptions but decreased their longitudinal effect. Our findings indicate that norm perceptions can be important sources of actual group influence as long these perceptions are consensually shared, and that especially high identifiers rely less on their unique norm perceptions over time.
Dynamically crosslinked thermoresponsive granular hydrogels
Authors: Lee Hung‐Pang , Cai Kathy Xiao , Wang Ting‐Ching , Davis Ryan , Deo Kaivalya , Singh Kanwar Abhay , Lele Tanmay P. , Gaharwar Akhilesh K.
Published: May 2023

Granular hydrogels are a promising biomaterial for a wide range of biomedical applications, including tissue regeneration, drug/cell delivery, and 3D printing. These granular hydrogels are created by assembling microgels through the jamming process. However, current methods for interconnecting the microgels often limit their use due to the reliance on postprocessing for crosslinking through photoinitiated reactions or enzymatic catalysis. To address this limitation, we incorporated a thiol‐functionalized thermo‐responsive polymer into oxidized hyaluronic acid microgel assemblies. The rapid exchange rate of thiol‐aldehyde dynamic covalent bonds allows the microgel assembly to be shear‐thinning and self‐healing, with the phase transition behavior of the thermo‐responsive polymer serving as secondary crosslinking to stabilize the granular hydrogels network at body temperature. This two‐stage crosslinking system provides excellent injectability and shape stability, while maintaining mechanical integrity. In addition, the aldehyde groups of the microgels act as covalent binding sites for sustained drug release. These granular hydrogels can be used as scaffolds for cell delivery and encapsulation, and can be 3D printed without the need for post‐printing processing to maintain mechanical stability. Overall, our work introduces thermo‐responsive granular hydrogels with promising potential for various biomedical applications.
The differential impact of COVID‐19 across health service psychology students of color: An embedded mixed‐methods study
Authors: Szkody Erica , Aggarwal Pankhuri , Daniel Katharine E. , Boland Jennifer K. , Sumida Catherine , Washburn Jason J. , Selby Edward A. , Peterman Amy
Published: May 2023

Objectives

Communities of color in the United States systematically experience inequities in physical and mental health care compared to individuals who identify as non‐Hispanic White. The coronavirus disease 2019 (COVID‐19) pandemic exacerbated these structural drivers of inequity to disproportionate and devastating effects for persons of color. In addition to managing the direct effects of COVID‐19 risk, persons of color were also navigating increased racial prejudice and discrimination. For mental health professionals and trainees of color, the effects of COVID‐19 racial health disparities and the increase in acts of racism may have been compounded by their work responsibilities. The current study used an embedded mixed‐methods approach to examine the differential impact of COVID‐19 on health service psychology (HSP) students of color as compared to their non‐Hispanic White peers.

Method

Using quantitative and qualitative data from the Epidemic‐Pandemic Impacts Inventory, measures of perceived support and of discrimination, and open‐ended questions about students' experiences with racism and microaggressions, we examined the extent to which different racial/ethnic HSP student groups experienced COVID‐19‐related discrimination, the impacts of COVID‐19 felt by students of color, and how these experiences differed from those of their non‐Hispanic White peers.

Results

HSP students of color endorsed greater impacts of the pandemic on both self and others in the home, perceived themselves as less supported by others, and reported more experiences of racial discrimination than non‐Hispanic White HSP students.

Conclusion

Throughout the graduate experience, HSP students of color and their experiences of discrimination need to be addressed. We provided recommendations to HSP training program directors and students both during and after the COVID‐19 pandemic.
Photocatalytic H2O2 Production by Thiophene‐Coupled Benzotriazole and Anthraquinone‐Based D−A‐Type Polymer Nanoparticles
Authors: Ghosh Nani Gopal , Sarkar Ayan , Sanke Devendra Mayurdhwaj , Karmakar Himadri Shekhar , Zade Sanjio S.
Published: May 2023

Herein, the photocatalytic generation of an important solar fuel—H2O2—by a thiophene‐coupled anthraquinone (AQ) and benzotriazole‐based donor (D)–acceptor (A) polymer (PAQBTz) nanoparticles is systematically reported. The visible‐light active and redox‐active D–A type polymer is synthesized employing the Stille coupling polycondensation, and the nanoparticles are obtained by dispersing the PAQBTz polymer and polyvinylpyrrolidone solution, prepared in tetrahydrofuran to water. The polymer nanoparticles (PNPs) produce 1.61 and 1.36 mM mg−1 hydrogen peroxide (H2O2) in the acidic and neutral media, respectively, under AM1.5G simulated sunlight irradiation (λ > 420 nm) with ≈2% modified Solar to Chemical Conversion (SCC) efficiency after 1 h of visible light illumination in acidic condition. The results of the various experiments lay bare the different aspects governing H2O2 production and indicate the H2O2 synthesis through the superoxide anion‐mediated and anthraquinone‐mediated routes.
A cross‐sectional study on factors affecting the intention to quit smoking among female call centre employees
Authors: Oh Hyunjin , Boo Sunjoo
Published: May 2023

Aim

This study aims to describe smoking related characteristics among female call centre employees in South Korea and identify the factors influencing intention to quit smoking in the next 6 months.

Design

This is a cross‐sectional study.

Methods

An anonymous online survey was conducted at three call centres of credit card companies in South Korea. Female employees with at least 6 months of experience (n = 115) who were currently smoking were included in this study.

Results

Overall, 20% of participants intended to quit within 6 months. Female call centre employees find it most difficult to resist the urge to smoke in negative mood situations. Factors affecting the quit intention were higher educational status, previous quit attempts lower perceived risk of craving and higher social support.

Public Contribution

Measuring and monitoring craving as perceived risk and providing social support can be useful for designing smoking cessation interventions in this population.
A linear adaptive second‐order backward differentiation formulation scheme for the phase field crystal equation
Authors: Hou Dianming , Qiao Zhonghua
Published: May 2023

In this article, we present and analyze a linear fully discrete second order scheme with variable time steps for the phase field crystal equation. More precisely, we construct a linear adaptive time stepping scheme based on the second order backward differentiation formulation (BDF2) and use the Fourier spectral method for the spatial discretization. The scalar auxiliary variable approach is employed to deal with the nonlinear term, in which we only adopt a first order method to approximate the auxiliary variable. This treatment is extremely important in the derivation of the unconditional energy stability of the proposed adaptive BDF2 scheme. However, we find for the first time that this strategy will not affect the second order accuracy of the unknown phase function by setting the positive constant large enough such that
The energy stability of the adaptive BDF2 scheme is established with a mild constraint on the adjacent time step radio . Furthermore, a rigorous error estimate of the second order accuracy of is derived for the proposed scheme on the nonuniform mesh by using the uniform bound of the numerical solutions. Finally, some numerical experiments are carried out to validate the theoretical results and the efficiency of the proposed scheme combined with the time adaptive strategy.
Impact of diagnostic and end‐of‐induction Curie scores with tandem high‐dose chemotherapy and autologous transplants for metastatic high‐risk neuroblastoma: A report from the Children's Oncology Group
Authors: Streby Keri A. , Parisi Marguerite T. , Shulkin Barry L. , LaBarre Brian , Bagatell Rochelle , Diller Lisa , Grupp Stephan A. , Matthay Katherine K. , Voss Stephan D. , Yu Alice L. , London Wendy B. , Park Julie R. , Yanik Gregory A. , Naranjo Arlene
Published: May 2023

Background

Diagnostic mIBG (meta‐iodobenzylguanidine) scans are an integral component of response assessment in children with high‐risk neuroblastoma. The role of end‐of‐induction (EOI) Curie scores (CS) was previously described in patients undergoing a single course of high‐dose chemotherapy (HDC) and autologous hematopoietic cell transplant (AHCT) as consolidation therapy.

Objective

We now examine the prognostic significance of CS in patients randomized to tandem HDC and AHCT on the Children's Oncology Group (COG) trial ANBL0532.

Study design

A retrospective analysis of mIBG scans obtained from patients enrolled in COG ANBL0532 was performed. Evaluable patients had mIBG‐avid, International Neuroblastoma Staging System (INSS) stage 4 disease, did not progress during induction therapy, consented to consolidation randomization, and received either single or tandem HDC (n = 80). Optimal CS cut points maximized the outcome difference (≤CS vs. >CS cut‐off) according to the Youden index.

Results

For recipients of tandem HDC, the optimal cut point at diagnosis was CS = 12, with superior event‐free survival (EFS) from study enrollment for patients with CS ≤ 12 (3‐year EFS 74.2% ± 7.9%) versus CS > 12 (59.2% ± 7.1%) (p = .002). At EOI, the optimal cut point was CS = 0, with superior EOI EFS for patients with CS = 0 (72.9% ± 6.4%) versus CS > 0 (46.5% ± 9.1%) (p = .002).

Conclusion

In the setting of tandem transplantation for children with high‐risk neuroblastoma, CS at diagnosis and EOI may identify a more favorable patient group. Patients treated with tandem HDC who exhibited a CS ≤ 12 at diagnosis or CS = 0 at EOI had superior EFS compared to those with CS above these cut points.
Research on improved gas‐assisted extrusion of plastic sheets based on time–temperature equivalence principle
Authors: Jiang Shiyu , Liu Hesheng , Yu Zhong , Ren Zhong , Jiang Qingsong , Li Zhibiao , Huang XueMei
Published: May 2023

Based on the time–temperature equivalence principle, the relationship between the melt relaxation time (MRT) and melt heating temperature (MHT) in an improved gas‐assisted extrusion (GAE) of a polypropylene (PP) sheet was investigated by numerical simulations. In the simulations, the MRT was varied and the inherent properties of the MHT were controlled using experimental methods. With an increase in MRT, the velocity in all directions, pressure drop, and shear rate of the melt increased; however, increasing the MRT does not always yield a positive effect on the GAE process of the melt. For instance, the melt velocity increased vertically at the die exit with MRT, resulting in an outward extrudate swell. In addition, the extruded product was intact when the melt was heated to 220°C, which verified the principle of time–temperature equivalence.
The relationship between patient enablement and help‐seeking in the context of blood cancer symptoms
Authors: Whitaker Katriina L. , Boswell Laura , Russell Jessica , Black Georgia B. , Harris Jenny
Published: May 2023

Objective

Approaches to improve earlier diagnosis of cancer often focus on symptom awareness as a key driver of help‐seeking behaviour and other psychological influences are less well understood. This is the first study to explore the role of patient enablement on help‐seeking for people experiencing potential blood cancer symptoms.

Methods

A cross‐sectional, nationally representative survey was completed by 434 respondents (>18 years). Questions asked about symptom experiences, medical help‐seeking and re‐consultation. Existing patient enablement items were included in the newly developed Blood Cancer Awareness Measure. We collected data on patient socio‐demographic characteristics.

Results

Of those responding to the survey 224/434 (51.6%) reported experiencing at least one potential blood cancer symptom. Half of those experiencing symptoms (112/224) had sought medical help. Results from logistic regression analysis showed that higher scores on patient enablement were associated with being less likely to seek help (Odds Ratio [OR] 0.89, Confidence Interval [CI] 0.81–0.98) after controlling for socio‐demographics. Separate analyses showed that higher enablement was associated with being more comfortable to re‐consult if symptoms didn't go away or got worse (OR 1.31, CI 1.16–1.48); after a test result suggested there was nothing to worry about, but symptoms persisted (OR 1.23, CI 1.12–1.34) or to request further tests, scans or investigations (OR 1.31, CI 1.19–1.44).

Conclusions

Contrary to our hypotheses, patient enablement was associated with lower likelihood of help‐seeking for potential blood cancer symptoms. Yet enablement appears to play an important role in likelihood of re‐consulting when symptoms persist, get worse or need further investigation.
Solute carrier family 35 member D3 promotes colorectal cancer progression through AMPK signaling pathway
Authors: Wang Xinyue , Lu Ya , Zhang Yuan , Wu Jianzhong , Ma Rong , Feng Jifeng
Published: May 2023

This article is aim to investigate the functional role and potential regulatory mechanisms of solute carrier family 35 member D3 (SLC35D3) in colorectal cancer. Beyond analyzing databases, western blot was used to detect and verify the expression of SLC35D3. Cell proliferation and invasion or migration ability were detected by CCK‐8, EdU, and Transwell assays. Animal experiments were conducted to verify if the biological function of SLC35D3 in vivo is consistent with that in vitro. Beyond SLC family pathway enrichment analysis, the relationship between SLC35D3 and metabolic pathway AMPK was explored using co‐immunoprecipitation and western blot. SLC35D3 is highly expressed in colorectal cancer (CRC) tissue. The overexpression or down regulation of SLC35D3 has been shown to promote or inhibit the biological functions of colorectal cancer, and similar experimental results can be verified in vivo experiments. Based on the high correlation between the SLC family and metabolic pathways, we chose the metabolic‐related AMPK pathway as the subject of our research. Co‐immunoprecipitation and protein analysis demonstrated that SLC35D3 may bind to AMPK molecules and regulate the AMPK pathway of colorectal cancer cells. Based on the above facts, SLC35D3 promotes colorectal cancer progression through regulating AMPK signaling pathway.
Antidepressant use during pregnancy and risk of stillbirth: A systematic review and meta‐analysis
Authors: Martin Florence Z. , Smith Sophie , Rai Dheeraj , Forbes Harriet
Published: May 2023

Introduction

To evaluate the current evidence estimating the association between antidepressant use during pregnancy and stillbirth.

Search Strategy

MEDLINE, EMBASE, and PsychINFO for studies investigating antidepressant use during pregnancy and risk of stillbirth, from inception until 21 January 2022.

Selection Criteria

Studies including pregnant women exposed to antidepressants during pregnancy investigating stillbirth were eligible, compared with either unexposed, indicated pregnant women or unexposed women in the general obstetric population.

Data Collection and Analysis

Data extraction and quality assessment were performed by two authors independently. Meta‐analysis was used to generate pooled‐effect estimates, and the ROBINS‐I tool was used to assess risk of bias for individual studies.

Main Results

Seventeen studies were eligible. Although estimates from meta‐analysis models suggest a small increased risk of stillbirth, summary effect estimate 1.19 (95% confidence interval [CI] 1.06, 1.34) between those individuals taking antidepressants during pregnancy and all other pregnant women, confounding control is likely inadequate. The risk of bias assessment showed most studies were low quality, with no studies scoring low risk; in a meta‐analysis of studies with moderate risk of bias (n = 2), no association was noted, summary effect estimate 1.17 (95% CI 0.97, 1.41). Only six studies adjusted for confounding by indication, the findings of which were summarised narratively.

Conclusions

Although the overall meta‐analysis found a small association between antidepressant use during pregnancy and stillbirth, this result was likely due to the overall low quality of studies included and by confounding in the underlying studies. Future studies must adequately address potential confounding by indication.
Data‐driven control of dynamic event‐triggered systems with delays
Authors: Wang Xin , Sun Jian , Berberich Julian , Wang Gang , Allgöwer Frank , Chen Jie
Published: May 2023

This article studies data‐driven control of unknown sampled‐data linear systems with communication delays under an event‐triggering transmission mechanism. While event‐triggered control has received much attention in the existing literature, its design and implementation typically require detailed model knowledge. Due to the difficulties in finding accurate models and the abundance of data in many practical applications, we propose a novel data‐driven event‐triggered control scheme for unknown, delayed systems with theoretical guarantees. To this end, as a first step, a model‐based stability condition for the resulting event‐triggered time‐delay system is established using a novel looped‐functional approach. Combining this model‐based condition with the data‐driven representation of linear systems, a data‐based stability condition is derived. Further, methods for co‐designing the controller gain and the event‐triggering matrix are subsequently provided without using any prior knowledge of the system matrices. Finally, numerical examples are presented to corroborate the merits of the proposed data‐driven event‐triggered control schemes relative to existing results.
Toward MBenes Battery Electrode Materials: Layered Molybdenum Borides for Li‐Ion Batteries
Authors: Majed Ahmad , Torkamanzadeh Mohammad , Nwaokorie Chukwudi F. , Eisawi Karamullah , Dun Chaochao , Buck Audrey , Urban Jeffrey J. , Montemore Matthew M. , Presser Volker , Naguib Michael
Published: May 2023

Lithium‐ion and sodium‐ion batteries (LIBs and SIBs) are crucial in our shift toward sustainable technologies. In this work, the potential of layered boride materials (MoAlB and Mo2AlB2) as novel, high‐performance electrode materials for LIBs and SIBs, is explored. It is discovered that Mo2AlB2 shows a higher specific capacity than MoAlB when used as an electrode material for LIBs, with a specific capacity of 593 mAh g−1 achieved after 500 cycles at 200 mA g−1. It is also found that surface redox reactions are responsible for Li storage in Mo2AlB2, instead of intercalation or conversion. Moreover, the sodium hydroxide treatment of MoAlB leads to a porous morphology and higher specific capacities exceeding that of pristine MoAlB. When tested in SIBs, Mo2AlB2 exhibits a specific capacity of 150 mAh g−1 at 20 mA g−1. These findings suggest that layered borides have potential as electrode materials for both LIBs and SIBs, and highlight the importance of surface redox reactions in Li storage mechanisms.
Mapping of the Electrostatic Potentials in a Fully Processed Led Device with nm‐Scale Resolution by In Situ off‐Axis Electron Holography
Authors: Cooper David , Licitra Christophe , Boussadi Younes , Ben‐Bakir Badhise , Masenelli Bruno
Published: May 2023

The optoelectronic properties of a fully processed red emitting AlGaInP micro‐diode device is measured using standard I‐V and luminescence measurements. A thin specimen is then prepared for in situ transmission electron microscopy analysis by focused ion beam milling, then the changes of electrostatic potential as a function of applied forward bias voltage are mapped by off‐axis electron holography. We demonstrate that the quantum wells in the diode sit on a potential gradient until the threshold forward bias voltage for light emission is reached; at which point the quantum wells are aligned at the same potential. From simulations, a similar effect for the band structure can be demonstrated, where the quantum wells are aligned at the same energy level, and contain electrons and holes that are available for radiative recombination at this threshold voltage. We demonstrate that off‐axis electron holography can be used to directly measure the potential distribution in optoelectronic devices, and is a powerful tool to help better understand their performance and to improve simulations.
HiRAM: A hierarchical risk assessment model and its implementation for an industrial Internet of Things in the cloud
Authors: Sun Wen‐Lin , Tang Ying‐Han , Huang Yu‐Lun
Published: May 2023

The trend towards intelligent control processes has introduced the Internet of Things (IoT) and cloud computing technologies to factories. IoT devices can sense data and send it to a cloud for further analysis in a factory. Consequently, the quantity of such valuable data flowing in an industrial cyber‐physical system has gradually increased. Tailoring a risk assessment system for Industrial IoT (IIoT) is essential, particularly for a cloud platform that handles the IIoT data flow. In this study, we leverage analytic hierarchy processes (AHPs) and propose Hierarchical Risk Assessment Model (HiRAM) for an IIoT cloud platform. The proposed model allows the platform to self‐evaluate its security status. Furthermore, a modular and responsive Risk Assessment System based on HiRAM, called HiRAM‐RAS, is realized and evaluated in a real‐world IIoT cloud platform. We deploy HiRAM‐RAS to a sample application and introduce the practical deployment procedures. We then estimate the practicality of the HiRAM‐RAS by injecting different degrees of errors and launching Distributed denial‐of‐service (DDoS) attacks. The results demonstrate the changes in integrity and availability scores evaluated by HiRAM.