bluuebunny/crossref_metadata_2025 huggingface dataset:
The Power of Makerspaces: Heterotopia and Innovation
Authors: Wu Yingqiu , Ma Zhonghong
Published: December 2022

“We all are makers” as a slogan of maker movement seemed to be a utopian imagination. Although spirits such as openness and sharing in the slogan successfully directed the attention of the government, the capital, and the general public to individual innovation, they might be unilaterally presented. Drawing upon Michel Foucault’s conceptualization of heterotopias, this article explores the features of makerspaces in Shenzhen, China, arguing that the heterogeneous culture generated by makerspaces played an essential role in stimulating innovation and expanding the impact of maker movement. This article presents four types of heterogeneous culture, the cultures of tolerance, liminality, compensation, and confrontation, which enriched the research on makerspaces and enhanced the status of makerspaces in innovation studies. Through the critical lens, this article shows the social and cultural meanings of makerspaces to makers, makerspace operators, and governments, calling for their rethinking in sustainable development of makerspaces.
Finding a New Home: Rerouting of Ferry Ships from Merak–Bakauheni to East Indonesian Trajectories
Authors: Kurniawan Abdy , Hutapea Gunung , Hardianto Sri , Suhartana I Ketut , Yuliani Apri , Putra Teguh Pairunan , Siahaan Wilmar Jonris , Hidayat Kamarul , Humang Windra Priatna , Paotonan Chairul , Paroka Daeng
Published: December 2022

As an archipelagic country, Indonesia needs ferry transportation to connect and support the economic activities between areas bounded by the sea. The famous crossing route is the Merak–Bakauheni one, which connects the Java and Sumatra economic corridors. Many ships operate on this route, but limited port facilities significantly affect the efficiencies of the services provided, hence, they have to be moved. Therefore, this research analyzed the suitability of ships to operate on the eastern crossing. The analysis method used the financial aspect (revenue) feasibility, the suitability of the port infrastructure, and the oceanographic conditions. The financial analysis used the ships’ operating cost method to determine the crossing passage rates based on their specifications. It simulated the ships with various load factors to identify potential gains or losses. Furthermore, the infrastructure suitability analysis used the under keel clearance and comparative methods to compare the suitability of the ship dimensions and tonnage with the port infrastructure capacity. The oceanographic analysis used the Weibull method to simulate the redefinition of the distribution of significant wave heights, which was compared with the ratio of the ship dimensions and wave slope to determine its heel angle using the IMO Weather Criterion method (IS Code 2008). The results showed that the relocation of ships from the Merak–Bakauheni route directly to Eastern Indonesia through the existing crossing routes is feasible from the aspect of shipping safety, but it is not feasible financially or in terms of infrastructure. The Benoa–Labuan Bajo route is a potential new route recommendation, with regulatory support for the operation of ships in the form of tariffs and operational costs, and it permits the use of subsidized fuel. On the other hand, ship owners must consider modifying the ramp door to suit the port wharf structure.
Machine Learning-Based Predictive Modeling of Sustainable Lightweight Aggregate Concrete
Authors: Hussain Fazal , Ali Khan Shayan , Khushnood Rao Arsalan , Hamza Ameer , Rehman Fazal
Published: December 2022

Nowadays, lightweight aggregate concrete is becoming more popular due to its versatile properties. It mainly helps to reduce the dead loads of the structure, which ultimately reduces design load requirements. The main challenge associated with lightweight aggregate concrete is finding an optimized mix per requirements. However, the conventional material design of this composite is quite costly, time-consuming, and iterative. This research proposes a simplified methodology for the mix designing of structural and non-structural lightweight aggregate concrete by incorporating machine learning. For this purpose, five distinct machine learning algorithms, support vector machine (SVM), artificial neural network (ANN), decision tree (DT), Gaussian process of regression (GPR), and extreme gradient boosting tree (XGBoost) algorithms, were investigated. For the training, testing, and validation process, a total of 420 data points were collected from 43 published journal articles. The performance of models was evaluated based on statistical performance indicators. Overall, 11 input parameters, including ingredients of the concrete mix and aggregate properties were entertained; the only output parameter was the compressive strength of lightweight concrete. The results revealed that the GPR model outperformed the remaining four machine learning models by attaining an R2 value of 0.99, RMSE of 1.34, MSE of 1.79, and MAE of 0.69. In a nutshell, these simplified modern techniques can be employed to make the design of lightweight aggregate concrete easy without extensive experimentation.
Analysis of COVID-19 Lockdown Effects on Urban Air Quality: A Case Study of Monterrey, Mexico
Authors: Schiavo Benedetto , Morton-Bermea Ofelia , Arredondo-Palacios Thania Elizabeth , Meza-Figueroa Diana , Robles-Morua Agustin , García-Martínez Rocío , Valera-Fernández Daisy , Inguaggiato Claudio , Gonzalez-Grijalva Belem
Published: December 2022

The COVID-19 pandemic has caused several millions of deaths and forced the world population to a new normality. This study aims to analyze the air quality variation of several gaseous pollutants (CO, NO2, SO2, O3, PM10, and PM2.5) during the pre-lockdown, lockdown, and unlock period in the city of Monterrey using ground-based measurements. In this research, we proposed to use a control period of previous years to identify parameter variation due to local climate. The results showed a drastic decrease in measured contaminants during the lockdown period as follows: SO2 (−41.9%) > PM10 (−30.5%) > PM2.5 (−25.6%) > NO2 (−14.9%) > CO (−9.8%) compared to the control period (2017–2019). The O3 was the only air pollutant that showed an opposite trend, increasing during lockdown (+15%) and unlock (+2.2%), whereas CO (−16.6%) and NO2 (−30.6%) were further decreased. Moreover, using OMI/AURA satellite data, we detected a NO2 tropospheric column reduction by −1.9% during lockdown concerning the same period in the control interval. Moreover, we found a significant improvement in the Air Quality Index (AQI) due to the lockdown. Our findings indicate an association between air pollutants and economic activity and can be used in future strategies to improve urban air quality.
Scientometrics-Based Research Status and Hot Topics Analysis of Chinese Private Colleges under Policy Guidance
Authors: Kuang Zhongqin , Jia Yan , Yang Jun
Published: December 2022

Private colleges play an important role in the cause of education, explore the research landscape and trends in development, and provide theoretical support and management practices for high-quality, healthy, and sustainable development. Based on a bibliometric analysis, and employing techniques such as scientometrics, social network analysis, a two-dimensional matrix, and textual analysis, this study analyzed the research literature on private colleges in the CSSCI database from 1998 to 2021, along with relevant policies from the legal literature database. This analysis addressed the dimensions of spatial and temporal distribution, author cooperation, primary journals, and research topics. The results showed a significant increase in the number of research papers published by private colleges, although with an uneven regional distribution of research development and differing influence and attention. The primary research forces of private colleges were mainly concentrated in the Jiangsu and Zhejiang regions. For scientific research cooperation, several core research groups were formed. According to the content analysis of relevant policies, the research of private universities has gone through three evolutionary stages: the lead period, the development period, and the adjustment period. Scholars in the lead period focused on learning about the advanced systems and concepts of foreign private colleges, while conducting research from a macro perspective. During the development period, the focus was on researching the management modes of Chinese private colleges from the medium point of view, while exploring different operating modes. During the adjustment period, private colleges research has returned to the macro level, exploring the classified management and governance of private colleges and re-examining China’s private colleges.
Citrinin Exposure in Germany: Urine Biomarker Analysis in Children and Adults
Authors: Degen Gisela H. , Reinders Jörg , Kraft Martin , Völkel Wolfgang , Gerull Felicia , Burghardt Rafael , Sievering Silvia , Engelmann Jennifer , Chovolou Yvonni , Hengstler Jan G. , Fromme Hermann
Published: December 2022

Citrinin (CIT), a mycotoxin known to exert nephrotoxicity, is a contaminant in food and feed. Since CIT contamination is not regularly analyzed, data on its occurrence and especially levels in food commodities are insufficient for conducting a conventional exposure assessment. Yet, human biomonitoring, i.e., an analysis of CIT and its metabolite dihydrocitrinone (DH-CIT) in urine samples allows to estimate exposure. This study investigated CIT exposure in young (2–14 years) and adult (24–61 years) residents of three federal states in Germany. A total of 179 urine samples from children and 142 from adults were collected and analyzed by a targeted LC-MS/MS based method for presence of CIT and DH-CIT. At least one of the biomarkers was detected and quantified in all urines, which indicated a widespread dietary exposure to the mycotoxin in Germany. Interestingly, the biomarker concentrations of CITtotal (sum of CIT and DH-CIT) were higher in children’s urine (range 0.05–7.62 ng/mL; median of 0.54 ng/mL) than in urines from adults (range 0.04–3.5 ng/mL; median 0.3 ng/mL). The biomarker levels (CITtotal) of individual urines served to calculate the probable daily CIT intake, for comparison to a value of 0.2 µg/kg bw/day defined as ‘level of no concern for nephrotoxicity’ by the European Food Safety Authority. The median exposure of German adults was 0.013 µg/kg b.w., with only one urine donor exceeding this provisional tolerable daily intake (pTDI) for CIT. The median exposure of children was 0.05 µg/kg bw per day (i.e., 25% of the pTDI); however, CIT exposure in 12 individuals (6.3% of our study group) exceeded the limit value, with a maximum intake of 0.46 µg/kg b.w. per day. In conclusion, these results show evidence for non-negligible exposure to CIT in some individuals in Germany, mainly in children. Therefore, further biomonitoring studies and investigations aimed to identify the major sources of CIT exposure in food commodities are required.
Reply to Henriksen, S.; Rinaldo, C.H. Should SVGp12 Be Used for JC Polyomavirus Studies? Comment on “Prezioso et al. COS-7 and SVGp12 Cellular Models to Study JCPyV Replication and MicroRNA Expression after Infection with Archetypal and Rearranged-NCCR Viral Strains. Viruses 2022, 14, 2070”
Authors: Prezioso Carla , Moens Ugo , Pietropaolo Valeria
Published: December 2022

In relation to the comment by Henriksen and Rinaldo, the authors intend to emphasize that before every experiment with SVGp12 cells they routinely test the cells for the absence of BKPyV contamination. The scientists can state that the SVGp12 cells used in their laboratory were not infected by BKPyV and that their results were also validated on the COS-7 cell line, which is permissive for JCPyV infection. Therefore, the overall findings of the study and its conclusions remain authentic. The authors recommend the necessity of carefully testing SVGp12 cells for BKPyV infection before use or, alternatively, in case of a first purchase; moreover, it is possible to choose different cell lines to avoid running into this unpleasant situation.
The Cold-Adapted, Temperature-Sensitive SARS-CoV-2 Strain TS11 Is Attenuated in Syrian Hamsters and a Candidate Attenuated Vaccine
Authors: Xu Jiayu , Liu Mingde , Niu Xiaoyu , Hanson Juliette , Jung Kwonil , Ru Peng , Tu Huolin , Jones Daniel M. , Vlasova Anastasia N. , Saif Linda J. , Wang Qiuhong
Published: December 2022

Live attenuated vaccines (LAVs) replicate in the respiratory/oral mucosa, mimic natural infection, and can induce mucosal and systemic immune responses to the full repertoire of SARS-CoV-2 structural/nonstructural proteins. Generally, LAVs produce broader and more durable protection than current COVID-19 vaccines. We generated a temperature-sensitive (TS) SARS-CoV-2 mutant TS11 via cold-adaptation of the WA1 strain in Vero E6 cells. TS11 replicated at >4 Log10-higher titers at 32 °C than at 39 °C. TS11 has multiple mutations, including those in nsp3, a 12-amino acid-deletion spanning the furin cleavage site of the S protein and a 371-nucleotide-deletion spanning the ORF7b-ORF8 genes. We tested the pathogenicity and protective efficacy of TS11 against challenge with a heterologous virulent SARS-CoV-2 D614G strain 14B in Syrian hamsters. Hamsters were randomly assigned to mock immunization-challenge (Mock-C) and TS11 immunization-challenge (TS11-C) groups. Like the mock group, TS11-vaccinated hamsters did not show any clinical signs and continuously gained body weight. TS11 replicated well in the nasal cavity but poorly in the lungs and caused only mild lesions in the lungs. After challenge, hamsters in the Mock-C group lost weight. In contrast, the animals in the TS11-C group continued gaining weight. The virus titers in the nasal turbinates and lungs of the TS11-C group were significantly lower than those in the Mock-C group, confirming the protective effects of TS11 immunization of hamsters. Histopathological examination demonstrated that animals in the Mock-C group had severe pulmonary lesions and large amounts of viral antigens in the lungs post-challenge; however, the TS11-C group had minimal pathological changes and few viral antigen-positive cells. In summary, the TS11 mutant was attenuated and induced protection against disease after a heterologous SARS-CoV-2 challenge in Syrian hamsters.
The 22nd Annual Meeting of the Rocky Mountain Virology Association
Authors: Ratnayake Oshani C. , Gendler Paul , Swartzwelter Benjamin , Keene Alexandra , Brehm Ali L. , Quackenbush Sandra L. , Rovnak Joel , Perera Rushika
Published: December 2022

Following the cause established twenty-two years ago, the 22nd Annual Rocky Mountain Virology Association meeting was held amidst the resplendent Rocky Mountains within the Arapahoe and Roosevelt National Forests. 116 intellectuals including both regional and international scientists as well as trainees gathered at the Colorado State University Mountain Campus for this three-day forum. Current trends in virology and prion disease research were discussed both in talks and poster presentations. This year’s keynote address emphasized innate immune modulation by arboviruses while other invited speakers shared updates on noroviruses, retroviruses, coronaviruses and prion diversity. Additionally, the need for and importance of better approaches for sharing science with non-science communities via science communication was discussed. Trainees and junior investigators presented 19 talks and 31 posters. This report encapsulates selected studies presented at the 22nd Rocky Mountain National Virology Association meeting held on 30 September–2 October 2022.
RNA Interference Approach Is a Good Strategy against SARS-CoV-2
Authors: Lee Ying-Ray , Tsai Huey-Pin , Yeh Chun-Sheng , Fang Chiung-Yao , Chan Michael W. Y. , Wu Tzu-Yun , Shen Cheng-Huang
Published: December 2022

COVID-19, caused by SARS-CoV-2, created a devastating outbreak worldwide and consequently became a global health concern. However, no verifiable, specifically targeted treatment has been devised for COVID-19. Several emerging vaccines have been used, but protection has not been satisfactory. The complex genetic composition and high mutation frequency of SARS-CoV-2 have caused an uncertain vaccine response. Small interfering RNA (siRNA)-based therapy is an efficient strategy to control various infectious diseases employing post-transcriptional gene silencing through the silencing of target complementary mRNA. Here, we designed two highly effective shRNAs targeting the conserved region of RNA-dependent RNA polymerase (RdRP) and spike proteins capable of significant SARS-CoV-2 replication suppression. The efficacy of this approach suggested that the rapid development of an shRNA-based therapeutic strategy might prove to be highly effective in treating COVID-19. However, it needs further clinical trials.
A Counterintuitive Neutrophil-Mediated Pattern in COVID-19 Patients Revealed through Transcriptomics Analysis
Authors: Özbek Melih , Toy Halil Ibrahim , Takan Işil , Asfa Seyedehsadaf , Arshinchi Bonab Reza , Karakülah Gökhan , Kontou Panagiota I. , Geronikolou Styliani A. , Pavlopoulou Athanasia
Published: December 2022

The COVID-19 pandemic has persisted for almost three years. However, the mechanisms linked to the SARS-CoV-2 effect on tissues and disease severity have not been fully elucidated. Since the onset of the pandemic, a plethora of high-throughput data related to the host transcriptional response to SARS-CoV-2 infections has been generated. To this end, the aim of this study was to assess the effect of SARS-CoV-2 infections on circulating and organ tissue immune responses. We profited from the publicly accessible gene expression data of the blood and soft tissues by employing an integrated computational methodology, including bioinformatics, machine learning, and natural language processing in the relevant transcriptomics data. COVID-19 pathophysiology and severity have mainly been associated with macrophage-elicited responses and a characteristic “cytokine storm”. Our counterintuitive findings suggested that the COVID-19 pathogenesis could also be mediated through neutrophil abundance and an exacerbated suppression of the immune system, leading eventually to uncontrolled viral dissemination and host cytotoxicity. The findings of this study elucidated new physiological functions of neutrophils, as well as tentative pathways to be explored in asymptomatic-, ethnicity- and locality-, or staging-associated studies.
Effects of Ammonium and COD on Fe and Mn Release from RBF Sediment Based on Column Experiment
Authors: Xia Xuelian , Teng Yanguo , Zhai Yuanzheng
Published: December 2022

Riverbank filtration (RBF) is an important part of the surface water–groundwater cycle, and it intercepts and retains many pollutants in rivers. However, RBF affects the biogeochemical process which enables aquifer sediments to release iron (Fe) and manganese (Mn). In this study, column experiments were performed to investigate the effects of ammonium ions and organic matter on Fe and Mn release from anaerobic RBF sediments. In addition, high-throughput sequencing technology was used to characterize the microbial community. The results showed that the ammonium ions (NH4+) and organic matter (COD) in groundwater promote the release of Fe and Mn from aquifer sediments. The trends of Fe and Mn release were similar during the leaching process. The maximum concentrations of Fe and Mn were 0.32 and 40 μg/L, respectively. The structural diversity and abundance of the microbial communities in the groundwater were closely related to the Fe/Mn content. Actinobacteriota, Proteobacteria, Acidobacteriota, Bacteroidota, and Chloroflexi were the dominant phyla, while Rhodococcus, Ochrobactrum, and Pseudarthrobacter were the dominant genera. These functional microbes are actively involved in the biogeochemical cycling of Fe, Mn, and N. In summary, contaminants and the microbial-community structure have dual effects on the release of Fe and Mn from RBF aquifers.
Assessment of Surface Water Quality Using the Water Quality Index (IWQ), Multivariate Statistical Analysis (MSA) and Geographic Information System (GIS) in Oued Laou Mediterranean Watershed, Morocco
Authors: Azhari Hamza El , Cherif El Khalil , Sarti Otmane , Azzirgue El Mustapha , Dakak Houria , Yachou Hasna , Esteves da Silva Joaquim C. G. , Salmoun Farida
Published: December 2022

Surface water is used for a variety of purposes, including agriculture, drinking water, and other services. Therefore, its quality is crucial for irrigation, human welfare, and health. Thus, the main objective is to improve surface water quality assessment and geochemical analysis to evaluate anthropogenic activities’ impact on surface water quality in the Oued Laou watershed, Northern Morocco. Thirteen surface water samples were characterized for 26 physicochemical and biological parameters. In this aspect, emerging techniques such as multivariate statistical approaches (MSA), water quality indices (WQI), irrigation water quality (IWQI), and Geographic Information System (GIS) were employed to identify the sources of surface water pollution, their suitability for consumption, and the distribution of surface water quality. The results showed that the major ion concentrations were reported in the following order: Ca2+, Na+, Mg2+, and K+; and HCO3− > CO32− > Cl− > SO42− > NO3− > F− > PO43− > NO2−. It was also demonstrated that almost all parameters had concentrations lower than World Health Organization (WHO) limits, except for bicarbonate ions (HCO3−) and the biochemical oxygen demand for five days (BOD5), which exceeded the WHO limits at 120 mg/L and 3 mg/L, respectively. Furthermore, the types of Ca2+-HCO3− (Calcium-Bicarbonate) and Ca2+-Mg2+-HCO3− (Calcium-Magnesium-Bicarbonate) predominated in surface water. The Principal Component Analysis (PCA) indicates that the Oued Laou river was exposed to two forms of contamination, the first being attributed to anthropogenic activities such as agriculture, while the second reflects the water-sediment interaction. The Hierarchical Cluster Analysis (HCA), reflecting the mineralization in the study area, has classified the samples into four clusters. The Inverse Distance Weighting (IDW) of the WQI indicates that 7.69% and 38.46% of the surface water represent, respectively, excellent and good quality for drinking. At the same time, the IWQI revealed that 92.30% of the water surface is good for irrigation. As a result, the combination of WQIs, PCA, IWQI, and GIS techniques is effective in providing clear information for assessing the suitability of surface water for drinking and its controlling factors and can also support decision-making in susceptible locations such as the Oued Laou river in northern Morocco.
Thyroid-Disrupting Effects of Cadmium and Mercury in Zebrafish Embryos/Larvae
Authors: Zhong Liqiao , Zhang He , Wu Luyin , Ru Huijun , Wei Nian , Yao Fan , Ni Zhaohui , Duan Xinbin , Li Yunfeng
Published: December 2022

Cadmium (Cd2+) and mercury (Hg2+) are two kinds of non-essential heavy metals. Cd2+ and Hg2+ can cause thyroid disruption, but very few researchers have investigated the thyroid-disrupting effects of these metals on fish, specifically during their early developmental transition stage from embryos to larvae. In this study, wild-type zebrafish embryos were exposed to varying concentrations (contents) of Cd2+ (0, 10, 100, and 1000 μg/L) and Hg2+ (0, 0.1, 1, and 10 μg/L) for 120 h. Thereafter, the thyroid hormone contents and transcriptional changes in the genes, including thyroid stimulating hormone-β (tshβ), thyroglobulin (tg), sodium-iodide symporter (nis), thyroid peroxidase (tpo), transthyretin (ttr), thyroid hormone receptor-α and -β (thrα, thrβ), types I and II iodothyronine deiodinase (dio1, dio2), and uridine diphosphate glucuronosyltransferase 1 family a, b (ugt1ab) associated with the hypothalamic-pituitary-thyroid (HPT) axis were measured. Results showed that zebrafish embryos/larvae malformation rates were significantly higher in the Cd2+ and Hg2+ groups. A significant increase in the thyroxine (T4) concentration and a decrease in the triiodothyronine (T3) concentration were observed in the Cd2+-exposed zebrafish embryos/larvae. On the other hand, the T4 and T3 concentrations were observed to be significantly increased after Hg2+ exposure. Additionally, changes were noted in the expression patterns of the HPT axis-linked genes after Cd2+ and Hg2+ exposure. Based on the results of the principal component analysis (PCA), it was concluded that Cd2+ exposure significantly affected the thyroid endocrine system at a concentration of 100 μg/L, whereas Hg2+ exposure led to a thyroid disruption at a low concentration of 0.1 μg/L. Thus, this study demonstrated that exposure to Cd2+ and Hg2+ metal ions induced developmental toxicity and led to thyroid disruption in zebrafish embryos/larvae.
Territórios jornalísticos: interseções, contraposições, complementações e similitudes nas definições conceituais
Authors: Souza José Jullian Gomes de , Lima Maria Érica de Oliveira
Published: December 2022

Como os conceitos acerca da relação entre jornalismo e território são abordados nas pesquisas em Comunicação e Jornalismo nos cursos de pós-graduação (mestrado e doutorado) no Brasil? Tendo essa pergunta como ponto de partida, nosso objetivo geral é analisar as interseções, contraposições, complementações e similitudes identificadas nas definições conceituais aplicadas nas pesquisas em comunicação e jornalismo, tendo como recorte analítico o uso dos conceitos de comunitário, local, regional, proximidade, interior e hiperlocal, que perpassam a relação com os territórios. Como objetivos específicos, propomos: (a) mapear a produção científica sobre jornalismo e território em programas de pós-graduação no Brasil; (b) analisar o conteúdo desses conceitos, como forma de observar como eles foram construídos e (c) observar as interseções e contraposições entre autores(as) e seus respectivos estudos. O quadro metodológico é composto por uma abordagem quanti-qualitativa, revisão bibliográfica e análise de conteúdo dos conceitos coletados, com recorte temporal entre 2005 e 2020. Constatamos com este estudo um número ainda reduzido de pesquisas que versam sobre os territórios jornalísticos na pós-graduação em Comunicação e Jornalismo no Brasil nos últimos quinze anos. Este artigo sinaliza também para as dificuldades de uma conceituação mais objetiva e os limites entre esses territórios de forma clara, não somente espacial, mas utilizando outros parâmetros (sociais, históricos, culturais, identitários etc.).
Reflexões sobre a importância do pânico sexual para a ascensão do bolsonarismo ao poder
Authors: Santos Allan
Published: December 2022

Com a finalidade de problematizar narrativas acríticas que creditam a ascensão do bolsonarismo ao poder como um efeito de discursos espontâneos e estrategicamente desarticulados, refletimos sobre a importância da mobilização afetiva pela manutenção das hierarquias de gênero e sexualidade para o fortalecimento desse movimento político. Nesse contexto, o trabalho examina alguns dos processos comunicacionais por meio dos quais políticas sexuais endossadas pelos governos petistas (2003-2016) foram estigmatizadas como ameaças ideológicas orquestradas por anormalidades perversas e degeneradas. O objetivo é investigar a publicação, feita por Jair Bolsonaro, de conteúdos digitais que normatizam a heterossexualidade como uma dimensão natural e constitutiva da existência humana para a midiatização do pânico sexual na cultura brasileira contemporânea. Por meio da análise histórico-processual de 12 postagens compartilhadas na página do então deputado federal no Facebook, foi observado que as formas de subjetivação que alimentam o fenômeno aqui investigado são estabelecidas por meio de três eixos discursivos: 1) os interesses perversos petistas na desconstrução da heteronormatividade; 2) os perigos da inclusão da ideologia de gênero nas escolas públicas do ensino básico; 3) a iminente ameaça pedófila encarnada pelo monstro moral contemporâneo.
A Preliminary Study for the Development of Guidelines In-Nursing School Clinical Practice Education for A National Disaster
Authors:   Korean Society of Nursing Research, Choi Gui Yun , Choi Eun Jin , Boo Yun Jeong , Sung Mi Ra , Jung Hee Young
Published: December 2022

Purpose : The purpose of this study is to examine and understand the basic data for developing in-school clinical practice education guidelines that can replace the nursing department’s field practice education in the event of national disasters such as COVID-19. Method : As a content analysis study using the focus group interviews, a total of 3 interviews were conducted with 13 nursing professors who were serving at the nursing colleges in 9 areas and who have had experiences in operating the in-school clinical practice. Results : In the area of practical education operation, the components of practice type, practice hours, the number of appropriately placement of students per practice unit, practice instructor, learning outcomes and practice goal setting, and the evaluation and management of academic achievement were derived. In terms of the practical education contents area, the composition of education content, practice method, and evaluation were derived. In terms of the practice education environment and system area, the components of contactless and face-to-face practice environment, regulations and operating system were derived. Conclusion : In the event of a disaster such as COVID-19, in order to maintain the quality of practice like field practice education and equip the nursing students with the nursing competency, while at the same time reducing the burdens of clinical practice operation in nursing colleges and avoiding confusion, standardized in-school practice education related operational guidelines need to be developed, and towards this end, the in-depth discussions between various clinical settings, academia and government ought to be held.
Mucormicose: aspectos epidemiológicos, métodos diagnósticos e condutas terapêuticas
Authors: Junqueira Júlia Teixeira de Souza , Costa Bruna Diuly Santos , Almeida Camila Lamounier Lellis de , Damasceno Sarah dos Santos , Porto Vitória Sturzeneker , Tozzi Ana Carolina Esteves , Paranhos João Carlos Junió Damasceno , Arão Ana Elisa Choucair Hosken , Esteves Reynaldo Afonso
Published: December 2022

A mucormicose, previamente denominada como zigomicose, consiste em uma infecção fúngica causada por fungos da ordem Mucorales, a qual pode ser classificada em seis grupos diferentes, a depender da localização acometida, podendo ser caracterizada como rinocerebral (mais comum), pulmonar, cutânea, gastrointestinal, diversa ou disseminada. Fisiopatologicamente, a mucormicose decorre da invasão tecidual e rápida disseminação do patógeno em tecidos profundos, dando origem a um processo inflamatório intenso, associado à necrose tecidual, especialmente em pacientes imunossuprimidos. A epidemiologia da mucormicose é bastante variada, a depender do país avaliado, sendo que sua incidência depende de diversos fatores e possui baixa prevalência global. Contudo, vale ressaltar que tal infecção ganhou maior relevância no contexto da pandemia do Covid-19 e, apesar de rara, tem sido relatados surtos, em especial na Índia. Em relação às manifestações clínicas e ao prognóstico, eles são diferentes a depender de cada caso, apesar do alto índice de morbimortalidade. No que tange ao diagnóstico, esse é, comumente, tardio e é realizado através da alta suspeição clínica, adquirida na anamnese e exame físico, associado a exames complementares, em especial, imagiológicos e laboratoriais, como histopatologia e culturas. O diagnóstico diferencial é imprescindível, uma vez que outras patologias com apresentações semelhantes devem ser descartadas, no intuito de se estabelecer o tratamento correto e eficaz. O manejo terapêutico é feito farmacologicamente com antifúngicos, como a Anfotericina B lipossomal e a ressecção de tecidos necrosados é o principal objetivo do manejo cirúrgico para tratamento de mucormicoses.
Perspectivas terapêuticas das doenças inflamatórias intestinais
Authors: Alvarenga Helen Laurrane Rinaldi de Freitas , Vargas Ana Elisa Assad Teixeira , Magalhães Ana Paula Gomes de Oliveira , Bessas Carolina Duarte Coelho , Rachid Clara de Moura , Gomes Daryelle Niesse , Kraychete Ian Garrido , Neto João José de Assis , Vieira Tiago Gonçalves de Araújo
Published: December 2022

A colite ulcerativa (CU) e a doença de Crohn (DC) representam as doenças inflamatórias intestinais (DII), um grupo de condições que possuem sintomas semelhantes e levam à inflamação do trato digestivo. A CU se caracteriza por uma inflamação limitada ao intestino grosso, de caráter crônico, alternando entre períodos de remissões e recidivas. Já na DC, a inflamação pode acometer todo o trato gastrointestinal, se apresentando de forma crônica, progressiva e remitente. A patogênese de ambas as doenças não é bem definida, entretanto, existe uma associação entre a predisposição genética e a exposição a fatores ambientais. A sintomatologia das DII são semelhantes e incluem dor abdominal, náuseas e vômitos, cólicas, fezes moles ou diarreia sanguinolenta, fadiga, anemia e perda de peso. Diante da presença destes sintomas e outras informações coletadas na anamnese, é necessário a solicitação de exames específicos para a confirmação da doença, como a radiografia do trato gastrointestinal superior, endoscopia, colonoscopia e amostragens do trato gastrointestinal. Embora as DII não tenham cura, há uma variedade de tratamentos disponíveis, que possuem como objetivo a remissão da doença. O manejo medicamentoso usual, consiste no uso de aminosalicilatos, corticosteróides, imunomoduladores, biológicos ou pequenas moléculas, que podem ser utilizadas em monoterapia ou associação. Entretanto, grande parte dos pacientes necessitarão de cirurgia, que possui como objetivo a conservação máxima do intestino possível, alívio das complicações e melhora da qualidade de vida. Além disso, nos últimos anos, novas terapias para as DII se desenvolveram, como terapia de aférese, microecologia intestinal melhorada, transplante de células-tronco e terapia de exossomos. Entretanto, seu uso é limitado, visto que ainda estão em protocolo de investigação.
Análise nos programas de treinamento de musculação publicados em revistas especializadas
Authors: Sousa Thiago Batista Campos de
Published: December 2022

O objetivo deste trabalho é destacar as inúmeras alternativas de prescrição de treinamento encontradas na literatura consultada, bem como as possibilidades de que o planejamento alcance um maior controle objetivo. Metodologia: Trata-se de uma revisão de literatura, o que possibilitou estudar o tema em fontes confiáveis como matérias em revistas especializadas, publicações em livros e em periódicos, tendo como autores atletas, treinadores e cientistas consagrados, ou opiniões dos mesmos em recursos que possibilitaram a sua preservação. Resultados: Durante o levantamento foi identificada certa resistência, para com treinamentos pré-estabelecidos, da parte de atletas e treinadores, porém os registros literários evidenciam as possibilidades de um planejamento menos subjetivo e mais numérico, objetivo. Conclusão: Concluímos que a literatura evidencia programas e estratégias que, feitos necessários ajustes, possibilitam um planejamento de treinamento menos subjetivo.
El worker como tema de la seguridad social en México
Authors: Violante Crisóforo Álvarez , Escobar Silvia Cartujano , Tarango Roque López , Lázaro Paula Ponce , Ramírez Selene Viridiana Pérez , Castellanos Ana Cristina Albores
Published: December 2022

La seguridad social nace con la finalidad de salvaguardar la integridad física de las personas, y con ello contrarrestar la desigualdad que había existido desde siglos atrás, desde su origen tuvo por objetivo garantizar principalmente el derecho a la atención médica, en la actualidad en México y en el mundo se ha garantizado este derecho y se han sumado otros derechos como son el acceso a pensiones, derecho a vivienda, derecho a una vida mejor.
Síndrome de Guillain Barre, uma complicação da Covid-19?
Authors: Manicardi Rafaela Pádua , Silva Ana Flávia Borges Carvalho e , Ribeiro Gabrielle Freitas , Ferreira Gabriel Silva , Tanures Leonardo Benevenuto Camargos Sena , Queirós Ana Clara Pinto Orlandi , Nascimento Sâmya Silveira , Almeida Marina Eduarda , Queiroz Isabella Bernanos Guimarães Rivelli de , Faria Camila Belfort Piantino
Published: December 2022

A doença ocasionada pelo vírus da COVID-19, a qual se consuma em estado pandêmico desde 2020, trouxe consigo sintomas respiratórios característicos. Além desses quadros já conhecidos, foi observado que tal patógeno pode gerar também manifestações extrapulmonares, como as de cunho neurológico. Uma intercorrência neurológica relatada foi a Síndrome de Guillain-Barré (SGB), que possivelmente se associa com a infecção por COVID-19, devido à capacidade do vírus em induzir autoanticorpos. Estudo descritivo de revisão de literatura do tipo integrativa foi realizado mediante análise nas bases de dados da Biblioteca Virtual em Saúde (BVS), U. S. National Library of Medicine (Pubmed) e Scientific Electronic Library Online (SciELO) sobre essa temática e, aplicou-se critérios de inclusão e exclusão e obteve-se 150 artigos, dentre os quais foram selecionados 05 estudos, que passaram por um processo de leitura minucioso. Na pesquisa foi observado que, dentre as síndromes autoimunes relacionadas a pós-infecção por sars-cov-2, a SGB foi a principal. Ademais, a ocorrência de SGB é preponderante em pacientes COVID positivo em comparação com as pessoas que testaram negativo para o vírus. Em relação a sintomatologia, observou-se que o padrão sensório-motor clássico foi o mais frequente da SGB. Além disso, considerando-se a variável idade evidenciou-se maior ocorrência da SBG em pacientes infectados por COVID-19 naqueles com idade superior a 63 anos. Há muitas evidências clínicas que correlacionam a infecção por COVID-19 com sequelas neurológicas e, a SBG é relevante nesse contexto. Contudo, há poucos estudos que investigam essa doença como complicação da COVID-19, o que denota ser necessária mais pesquisas que busquem relacionar tais doenças.
Effect of different led spectrum regimens on growth and development of Betula pubescens Ehrh. and Rubus idaeus L. in culture in vitro
Authors: Evlakov Petr , Grodeckaya Tatyana , Fedorova Olga , Shestakov Roman , Baranov Oleg
Published: December 2022

Light-emitting diodes (LEDs) have shown high efficiency in growing plants both in vivo in greenhouses and in vitro, including clonal micropropagation. The purpose of this study was to analyze the effect of the spectral composition of LED irradiators with different proportions of red (RL) and blue (BL) light on the morphogenesis of microplants of the remontant form of common raspberry (Rubus idaeus L.) cv. Hercules and the selection valuable cultivar of downy birch (Betula pubescens Ehrh.), which is the object of a unified genetic breeding complex (UGBC), previously selected on the basis of drought resistance. In the variant 1, the RL/BL ratio was 80/20%, in the variant 2 it was 70/30%, in the control it was 50/50%. The LED in variant 1 contributed to the greatest increase in morphometric and anatomical characteristics in raspberry microplants, increasing the height of shoots, the number of leaves, stomata density, the height of the leaf epidermis and mesophyll. At the same time, an increase in the proportion of RL/BL led to an increase in the leaf area, leaf surface, and stomatal density in birch microclones; however, the anatomical characteristics of the leaf indicate a decrease in the height of epidermal cells and the size of mesophyll cells. Thus, the LED of option 1 can be recommended for use in clonal micropropagation of raspberries in greenhouses, to optimize growth processes and obtain healthy, normally formed plants, while birch requires additional selection of optimal spectral illumination conditions.
Knowledge Evaluation of Accredited Social Health Activists (ASHAs) on Maternal and Child Health, in a Rural Area of Gomati District, Tripura
Authors: Mitra Dr. Sampa
Published: December 2022

Background: National Rural Health Mission (NRHM) provides a trained female community health worker i.e., Accredited Social Health Activist (ASHA), to every Indian village. An ASHA acts as a bridge between the rural people and the health service outlets.
Objective: The objective is to understand the knowledge levels of ASHAs regarding various aspects of maternal and child health.
Method: This cross-sectional study, conducted between April 2017 and July 2017, attempts to assess the knowledge levels of 232 ASHAs, working in Ompi CHC (Community Health Centre), Killa PHC (Primary Health Centre) and Atharabula PHC. These centres are located in Ompi RD (Rural Development) Block and Killa RD Block of Gomati District of Tripura. Knowledge level is assessed by performing binomial test at 5% level of significance.
Hastanelerde Yangınla Mücadelede Acil Durum Yönetimine İlişkin Kritik Başarı Faktörlerinin Belirlenmesi
Authors: TOSUN Samet , YILMAZ İbrahim
Published: December 2022

Günümüzde sağlıkta uygulanan politikalar ve insani gerekler sonucu olarak normal hastanelerin yanı sıra birçok entegre sağlık kampüsleri ve şehir hastaneleri inşa edilmeye başlanmıştır. Gerek nicelik, gerekse nitelik bakımından büyüyüp gelişen bu sağlık kompleksleri beraberinde yangın riskini ve çıkabilecek yangınla mücadelede acil durum yönetimi üzerine mevcut düzenleme ve planlamaların yeterli olup olmadığı sorusunu da gündeme getirmiştir. Sağlık tesisleri ve hastanelerin tasarımları, bünyesinde yer alan hassas ve karışık üniteler ve hareket kabiliyeti kısıtlı olan kullanıcıların profili sebebiyle, mümkün oldukça en güvenli ve en verimli biçimde yapılmalıdır. Yapılan araştırmada hastanelerde yangın özelinde kapsamlı bir acil durum yönetimi çalışmasına rastlanmamıştır. Literatürdeki bu boşluğu doldurmak amacıyla hastanelerin ve sağlık kurumlarının yangınla mücadelede acil durum yönetimine ilişkin kritik başarı faktörlerinin literatür araştırması yapılarak tespit edilmesi ve AHP yöntemiyle ağırlıklandırılması amaçlanmıştır. Çalışma sonucunda hastaneler için ayrı, özel bir yönetmelik gerektiği farkındalığının sağlanması, hastanelerde yangından korunmak için yapılacak bütçe çalışmalarında kritik başarı faktörlerinin (KBF) ağırlıklarına göre planlama yapılması tavsiye edilmiştir. AHP yöntemi sonucunda elde edilen KBF ağırlıkları incelendiğinde en önemli iki faktörün yönetmeliklerdeki eksiklikler ve mimari tasarım olduğu görülmüştür.
Tedarikçi Seçiminde Dematel ve Aksiyomatik Tasarım Tekniği Uygulaması
Authors: EMMİ Şule , GÜLER Ezgi , AVCI Selen , ALADAĞ Zerrin
Published: December 2022

Tedarik zinciri yönetiminin en önemli adımlarından biri olan doğru tedarikçi seçimi, rekabetçi koşullarda işletmenin belirlemiş olduğu hedeflere ulaşmasında büyük önem taşımaktadır. Bu çalışmada, lojistik sektöründe faaliyet gösteren bir firmada tedarikçi seçim problemi ele alınmıştır. Öncelikle, tedarikçi seçiminin yapılacağı ürün grubunun belirlenmesi amacıyla FSN (Fast-Slow-NonMoving) analizi ile kritik yedek parça seçilmiştir. Ardından, problemin çözümü için Çok Kriterli Karar Verme (ÇKKV) tekniklerinden Aksiyomatik Tasarım ve Dematel (The Decision Making Trial and Evaluation Laboratory) yöntemleri önerilmiştir. Tedarikçi seçimine etki eden kriterler arasındaki ilişki Dematel ile yorumlanmış ve kriterler “etkileyen” ve “etkilenen” olarak iki gruba ayrılmıştır. Tedarikçiler arasında seçim ve sıralama ise Aksiyomatik Tasarım ile gerçekleştirilmiştir. Ayrıca kriterlerin eşit ağırlığa sahip olmadığı durum da gözönüne alınarak kriterler Analitik Hiyerarşi Prosesi (AHP) yöntemiyle ağırlıklandırılmış ve alternatifler Ağırlıklı Aksiyomatik Tasarım ile yeniden sıralanmıştır. Son olarak, Dematel yönteminde “etkilenen” olarak belirlenen kriterler analizden çıkarılarak metodoloji tekrarlanmıştır. Böylece kriterler arasındaki neden-sonuç ilişkisinin belirlenmesinin sonuçlara etkisi yorumlanmıştır.
Sürdürülebilir Beslenme Kapsamında Yenilebilir Böcekler
Authors: SEYHAN Selen , NAKİLCİOĞLU Emine
Published: December 2022

İlerleyen yıllarda dünya nüfusunun 9 milyarı geçeceği öngörülmektedir. Artan nüfus, şehirleşme oranının büyümesi, ekonomik nedenler ve bazı çevresel faktörler nedeniyle, insanların yeterli miktarda hayvansal ürün kaynaklarına ulaşmada büyük sorunlar yaşayacağı düşünülmektedir. Bu sebeple geleneksel protein kaynakları yetersiz kalacak olup, yenilebilir böceklerin alternatif protein kaynakları olarak hesaba katılması gerekecektir. Günümüzde karıncalar, çekirgeler, arılar, eşek arısı, cırcır böcekleri ve daha nicesinin dahil olduğu birçok böcek türü yenilebilmektedir. Dünyada yaklaşık olarak 1.900’den fazla böcek türünün yenilebilir olduğu, bu böcek türlerinin insan gıdası olarak kullanıldığı ve dünya çapında yaklaşık 2 milyar insanın böcek tükettiği bilinmektedir. Bitkisel ve hayvansal proteinler ile böcek proteinleri karşılaştırıldığında esansiyel aminoasit profili, toplam protein seviyesi ve diğer besin değerleri bakımından yenilebilir böcekler değerli kaynaklardır. Ayrıca elde edilen biyoaktif maddeler sağlığın geliştirilmesi ve hastalıkların önlenmesinde kullanılabilmektedir. Literatürde gıda alanında yenilebilir böcekler ile ilgili çalışmalar mevcuttur ve her geçen gün artmaktadır. Bu derleme çalışmasında, yenilebilir böceklerden olan kriket böceği (Acheta domesticus), un kurdu (Tenebrio molitor), siyah asker sineği (Hermetia illucens), çekirge (Locusta migratoria) ve ipek böceği (Bombyx mori) ile ilgili bilgi verilmesi ve gıda alanında kullanımı hakkında bilgi aktarımının sağlanması amaçlanmıştır.
Analysis of physical conditions and basic skills of table tennis players in malang city
Authors: Nurrochmah Siti , Furrochman Rachmad Fariz , Firmansyah Guntur
Published: December 2022

The purpose of this study was to determine and examine the description of the physical condition that has components which are strength, agility and reaction speed as well as basic service and drive technical skills possessed by table tennis athletes in Table Tennis Federation of Malang City. This research is a quantitative descriptive type and uses an observational test approach. The population was 55 people and the sampling used a purposive proportionate random sampling technique with a portion of 90% of 55 people, a total sample of 50 people. Data collection uses measurement techniques in the form of physical condition tests and sports skills tests. The results obtained in the components of agility, arm muscle strength, reaction speed, as well as basic drive technical skill were in the "enough" category, the dominant arm muscle strength component is "sufficient", the dominant reaction speed component is "enough", the basic dominant technique skills are "insufficient", and the basic dominant drive technique skills are "enough". The conclusion of the research results indicated that each component of physical condition obtained a “satisfactory” category whereas the basic technical skills mostlyobtained a “satisfactory” category. Keywords: Physical condition, strength, agility, reaction speed, serve, drive.
Klotho Protein and Type 2 Diabetes Mellitus
Authors: DOKUMACIOĞLU Eda , ISKENDER Hatice
Published: December 2022

Diabetes mellitus (DM) is considered an epidemic disease by many countries and shown as one of the leading causes of death in western societies. In the development of the disease, the underlying pathophysiological mechanisms are complex and multifactorial. The frequency of DM increases with age, and the severity of events such as oxidative stress and inflammation increases in patients diagnosed with DM. The Klotho (KL) protein, defined as a new anti-aging protein as a result of the studies on aging mechanisms and it has an important functions on glucose homeostasis and insulin secretion. In this review study, the relationship between KL protein and DM is explained by compiling the information in the articles published in PubMed indexed journals between 2002-2020. In conclusion, a decrease in KL levels plays a role in type 2 DM and the development of nephropathy and vascular diseases caused by type 2 DM.