bluuebunny/crossref_metadata_2025 huggingface dataset:
THE RESEARCH OF THE EFFECTIVENESS OF SMALL TACTICAL GROUPS IN THE SERVICE AND COMBAT ACTIVITIES OF LAW ENFORCEMENT
Authors:   Kharkiv National University of Internal Affairs, Vlasenko I. , Shevchenko T. ,   Kharkiv National University of Internal Affairs, Sidelnikov B. ,   Kharkiv National University of Internal Affairs, Panchenko V. ,   The National academy of the National Guard of Ukraine
Published: December 2022

The research of the effectiveness of small tactical groups in the service and combat activities of law enforcement. The work considers increasing the efficiency of small tactical groups due to the criterion approach. The choice of battle formation, the optimal number of personnel, the qualitative composition of a small tactical group depends on the conditions of the battle (location, terrain, vegetation, time of day, time of year, the number and types of enemy weapons, the tasks of the small tactical group, etc.). One of the main criteria for the effectiveness of the actions of a small tactical group is the degree of protection of the group, the absence of losses among the personnel of the group in the conditions of conducting search operations, possible fire contact and combat. Personal security measures depend on the group's tactics and vary them. Improving the tactics of actions of small tactical groups based on personal safety measures is a promising addition to research. The cited results of studies of one of the tactical criteria, such as the reduction of the probability of losses. To study this issue, a mathematical method was used using trigonometric functions. Depending on the direction of fire of one enemy, the angle of the firing sector was determined. The boundary condition is the requirement, that the larger the shooter's firing sector, the greater the probability of hitting the entire group. The next condition for reducing losses is the maximum number of group fighters who are on the same line. The fewer group members are on the same line, the less likely the group will be defeated. The type of combat formation and the way it moves during fire contact can reduce possible losses. As a result of the analysis of the criterion, the recommendations are given to improve the efficiency of small tactical groups.As a result of the conducted analysis, it was established that the degree of protection is influenced by the methods and pace of movement, camouflage, communication in a stable group, which is the direction of our further research. The conducted experiments confirmed the theoretical and empirical studies.
ORGANIZATIONAL AND TACTICAL PRINCIPLES OF JOINT EXECUTION	BY THE SECURITY FORCES, JUDICIAL AND LAW ENFORCEMENT BODIES	OF UKRAINE OF SERVICE AND COMBAT TASKS TO ANTI-SMUGGLING
Authors:   Dnipropetrovsk State University of Internal Affairs, Krylovetskiy A.
Published: December 2022

The issue of the interaction of the security forces, judicial and law enforcement agencies of Ukraine during the performance of official and combat tasks to combat smuggling has been updated. An analysis of modern scientific intelligence was carried out regarding the substantiation of the concepts and features of the organizational and tactical principles of the joint execution of official and combat tasks in the fight against smuggling by the security forces, judicial and law enforcement agencies of Ukraine. It has been established that the existing scientific works reveal the regulatory, legal and organizational aspects of the service and combat activities of the law enforcement forces, however, the issue of substantiating the concepts, principles and features of the organizational and tactical principles of joint implementation by the security forces, judicial and law enforcement agencies of Ukraine on an official basis is still not sufficiently developed ‒ combat missions to combat smuggling. It was determined that the analysis of the regulatory and legal framework of Ukraine and the research of the scientific community shows that there is currently insufficient regulatory definition of categorical concepts, such as «type», «form» and «method» of service and combat activity of security forces, judicial and law enforcement agencies of Ukraine. The development of the organizational and tactical forces of the security, judicial and law enforcement agencies of Ukraine during the performance of official and combat tasks to combat smuggling consists in the further development of such a type of official and combat combat activity as special actions, of such a form as a special operation based on the improvement of compatible methods of official ‒ combat activity during the organization of search-and-strike, isolation-restriction, and defense-security operations. It has been proven that in the future it is appropriate to carry out new research on the improvement of existing types of service-combat activity, as well as forms and methods of performance of service-combat tasks in the field of combating smuggling.
THE CONDITION FOR ASSESSING THE ADEQUACY OF MODELS FOR PROTECTING STATE INFRASTRUCTURE OBJECTS FROM AIR BLOWS DURING HOSTILITIES
Authors:   The National academy of hte National Guard of Ukraine, Gorodnov V. , Ovcharenko V. ,   Kyiv Institute of the National Guard of Ukraine, Kovalev I. ,   The National academy of hte National Guard of Ukraine
Published: December 2022

To control the adequacy of the mathematical models for planning and managing the defense against air blows on the covered state infrastructure objects by the most effective means ‒ groupings of surface-to-air missile systems during military operations, an analytical description of the internal law of air defence battles was found. The presence of the noted law in the developed mathematical models can be a criterion for their adequacy to real processes of combat operations and a necessary condition for the models applicability in practice
NORMATIVE, LEGAL AND ORGANIZATIONAL PRINCIPLES OF DEOCCUPATION OF THE AUTONOMOUS REPUBLIC OF CRIMEA
Authors:   Lesya Ukrainka Volyn National University, Batiuk O.
Published: December 2022

The provisions of the normative legal acts defining the principles of deoccupation and reintegration of the temporarily occupied territory of the Autonomous Republic of Crimea and the city of Sevastopol are outlined. It is emphasized that a background for international recognition that Ukraine is consistent in its actions to restore territorial integrity that was violated as a result of neglect by the Russian Federation of its international obligations, is a number of legal acts that have been adopted in 2014 and that define the organizational, normative and legal principles of de-occupation and reintegration of the temporarily occupied territory of the Autonomous Republic of Crimea and the city of Sevastopol. Legal relations that are the subject of regulation of deoccupation and reintegration of the temporarily occupied territory of the Autonomous Republic of Crimea and the city of Sevastopol are regulated by the Constitution of Ukraine, laws of Ukraine, in particular "On Ensuring the Citizen's Rights and Freedoms and the Legal Regime on the Temporarily Occupied Territory of Ukraine", "On The Administration Of Justice And Criminal Proceedings In Connection With The Conduct Of The Anti-terrorist Operation", "On Temporary Measures for the Anti-Terrorist Operation Period", "On Ensuring Rights And Freedoms Of Internally Displaced Persons", "On Military-Civilian Administrations", "On The Peculiarities Of State Policy To Ensure The State Sovereignty Of Ukraine On The Temporarily Occupied Territories In The Donetsk And Luhansk Regions", etc., by international treaties, the consent of which was given by the Verkhovna Rada of Ukraine to be binding. It was concluded that the activity of the occupying forces and occupation administrations of Russia directly contradicts the norms of international law, is illegal, and any act issued in connection with such activity is invalid and does not create any legal consequences. Normative and legal acts of the aggressor state that are related to temporary occupation, normative and legal acts of the occupying forces and occupation administrations of Russia are null and void and do not create any legal consequences. The nullity of these acts is not subject to appeal and cannot be annulled.
AN IMPROVEMENT OF NORMATIVELY-LEGAL ADJUSTING OF SPHERE OF SAFETY AND DEFENSIVE IS IN THE CONDITIONS OF THE MILITARY AGGRESSION
Authors:   Kyiv Institute of the National Guard of Ukraine, Tkachenko O. , Yevtushenko I. ,   Institute for training legal personnel for the Security Service of Ukraine of Yaroslav the Wise National University of Law
Published: December 2022

The proposed article reviews the regulatory and legal support of the spheres of national (state) security of the country, the content of individual planning documents in the spheres of national security to improve the legislation of the spheres of national (state) security. The analysis of the bills adopted by the Verkhovna Rada of Ukraine after the introduction of martial law in Ukraine, which are aimed at improving the security and defense spheres, is carried out. Attention is drawn to the fact that the state's counteraction to threats of various levels through legal mechanisms is the task of the system of national (state) security of the state and should be carried out in coordination and interaction of the legislative body with all subjects of the security and defense sector, therefore, the legislation of Ukraine on national security should regulate the solution of many specific legal problems. The proposals on the directions of improvement of the system of legislation in the sphere of security and defense, national (state) security in order to ensure a holistic and comprehensive state policy of present and future security of Ukraine and the creation of the necessary mechanisms for all subjects of public relations that can be involved in the implementation of tasks in the interests of state security are provided.
SUBSTANTIATION OF THE METHODOLOGY FOR CALCULATING THE CONSUMPTION DEMAND FOR PUBLIC UTILITIES IN A MILITARY UNIT
Authors:   The National academy of hte National Guard of Ukraine, Derevianko M. , Kaplun S. ,   The National academy of hte National Guard of Ukraine, Putro O. ,   The National academy of hte National Guard of Ukraine
Published: December 2022

The paper substantiates the relevance of using the algorithm for calculating the annual consumption demand for public utilities in a military unit, which is the basis of the Plan for providing a military unit with public utilities. In modern conditions, the uninterrupted provision of public utilities plays a significant role in increasing the combat readiness of the troops, allows catering for the cultural and daily living needs of military personnel, and it is of great importance for protecting their health and maintaining a high moral and psychological condition. Reliable and qualitative provision of public utilities for the needs of personnel and maintenance of military units in appropriate condition is the primary task of the housing maintenance service of a unit. In order to enable the authorities of the housing maintenance services to make a well-founded and justified claim for the necessary funds to be included in the budget with the objective to ensure uninterrupted, complete, reliable and qualitative provision of public utilities for the needs of personnel and maintenance of military units in appropriate condition, it is necessary to have a scientific and methodological apparatus that will allow to make the correct and well grounded decision, confirmed by calculations and economic justifications. The final result of the calculation of the annual demand of a particular public utility is influenced by a large number of various factors that must be taken into account when conducting appropriate calculations of the consumption demand, planning and providing with public utilities. With the help of the proposed expressions, reasonable calculations of the annual consumption demand for public utilities in a military unit (subdivision) can be carried out.
MATHEMATICAL MODEL OF STORAGE OF AVIATION WEAPONS USING DIFFUSION-NONMONOTONIC DISTRIBUTION OF THEIR FAILURES
Authors:   Ivan Chernyakhovsky National University of Defense of Ukraine, Piavchuk O. , Yablonskyi P. ,   Ivan Chernyakhovsky National University of Defense of Ukraine, Openko P. ,   Ivan Chernyakhovsky National University of Defense of Ukraine, Dyptan V. ,   Ivan Chernyakhovsky National University of Defense of Ukraine
Published: December 2022

The modern stage of the functioning of the Armed Forces of Ukraine, like many other countries of the world, is characterized by the presence of a significant number of aviation means of attack in their armament and military equipment, the resource indicators of which have been exhausted or are at the stage of completion. At the same time, the vast majority of them were developed and manufactured in the Soviet Union, after the collapse of which their developers and manufacturers were abroad, mainly in the Russian Federation. As a result, copyright supervision on the territory of Ukraine ceased to be carried out at the end of 1991, and the system of ensuring serviceability actually ceased to exist. This led to the fact that aviation means of destruction gradually exhausted not only the warranty, but also the designated resource indicators (service terms, storage terms), as a result of which their further operation should be stopped, first of all, for safety reasons. At the same time, after the large-scale aggression of the Russian Federation, Ukraine received military and technical assistance from foreign partner countries, including aviation weapons, which must be stored, maintained and restored in case of malfunction. Thus, the current situation requires a well-founded decision to provide the Armed Forces of Ukraine with serviceable aviation means of attack. At the same time, the issue of maintaining the serviceability of aviation means of destruction and their restoration comes to the fore. The article describes a mathematical model of the process of operation (storage) of aviation weapons containing an electromechanical basis, with the application of the diffusion-nonmonotonic law of distribution at the "use" and "maintenance" stages of the life cycle. At the same time, to describe the processes taking place in the mathematical model, a semi-Markov random process is used, and the coefficient of technical use is chosen as a criterion for the efficiency of the technical operation of aviation weapons. The dependence of the coefficient of technical use on the scale and form of the diffusion-nonmonotonic distribution law, the periodicity of technical maintenance, the reliability of control, and the duration of the restoration of the failed product was established.
PROBLEMS OF INFORMATIZATION OF THE MANAGEMENT PROCESSES OF THE SYSTEM OF MAINTENANCE AND REPAIR OF ARMORED TANK VEHICLES
Authors:   The National academy of hte National Guard of Ukraine, Yemanov V. , Sporyshev K. ,   The National academy of hte National Guard of Ukraine, Shapovalov O. ,   The National academy of hte National Guard of Ukraine
Published: December 2022

An analysis of existing problematic issues in the system of maintenance and repair of armored vehicles of the National Guard of Ukraine was carried out. Management of the system of maintenance and repair of weapons and military equipment of military formations is an integral part of management of technical support. It consists in the purposeful activity of the system management body in maintaining the weapons park and military equipment in good condition and ensuring the constant combat readiness and combat capability of military formations both in peacetime and during the preparation and during the conduct of special operations (combat operations). Analysis of the content of management of the system of maintenance and repair of weapons and military equipment allows to outline the general order of management and to determine the main functions of management: ‒ continuous collection, analysis and summarization of data on changes in combat capability and combat readiness of weapons and military equipment; ‒ development of proposals for the organization of restoring the working condition of faulty equipment based on the tasks set and taking into account the conditions of the situation; ‒ continuous collection, analysis and summarization of data on the state of its forces and means of repair of weapons and military equipment, production capabilities of repair enterprises (organizations, institutions) at the point of permanent deployment or in the area of service-combat assignment of military formations; ‒ planning and organization of restoration of combat capability and combat readiness of weapons and military equipment; ‒ organizing and monitoring the performance of assigned tasks and providing assistance to management bodies at all levels of the maintenance and repair system. This requires determining directions for increasing the efficiency of the management of the system of maintenance and repair of weapons and military equipment. One of these directions is the informatization of the management processes of the maintenance and repair system of weapons and military equipment. Considered possible ways to reduce the influence of negative factors on the efficiency of the operation of systems of operation and restoration of armored vehicles.
IMPROVEMENT OF THE METHODOLOGY OF ASSESSING THE IMPACT OF THE ACTIVITIES OF THE CIVIL-MILITARY COOPERATION UNITS ON THE PERFORMANCE OF THE ASSIGNED TASKS OF THE NATIONAL GUARD OF UKRAINE DURING THE ARMED CONFLICT SETTLEMENT
Authors:   The National academy of hte National Guard of Ukraine, Mynko О. , Bielai S. ,   The National academy of hte National Guard of Ukraine, Turchinov A. ,   The National academy of hte National Guard of Ukraine
Published: December 2022

Three basic components , which directly affect the achievement of goals and the effective performance of the tasks of the civil-military cooperation are considered. A brief analysis of the existing practices of evaluating the activities of civil-military cooperation structural units and the evaluation methodology used by civil-military cooperation specialists of the Armed Forces of Ukraine was carried out. The existing indicators of the effectiveness of the results of civil-military cooperation activities were analyzed. Presented an improved list of criteria for the effectiveness of civil-military cooperation activities, taking into account the specifics of the tasks assigned to the National Guard of Ukraine and a list of possible indicators of positive dynamics (positive changes in the situation) as a result of the operation of the system of civil-military cooperation of the military formation of the National Guard of Ukraine while the performance of assigned tasks, during the settlement of the armed conflict. An improved methodology for assessing the impact of the activities of civil-military cooperation units on the performance of assigned tasks by the formations of the National Guard of Ukraine during the settlement of the armed conflict is proposed.
Consumption of ultra-processed foods and metabolic syndrome in adolescents: a systematic review protocol
Authors: Lima Luiz Eduardo Rodrigues , Leonel Camila Ferreira , Mori Bruno , Lima Regismeire Viana , Souza Celsa Moura , Camargo Érika Barbosa , Rossato Mateus
Published: December 2022

Objective: This protocol will describe the methods of a systematic review that examined studies on the relationship between consumption of ultra-processed foods and metabolic syndrome in adolescents. Methods: The searches will be carried out in the MEDLINE (via PubMed), EMBASE (via ScienceDirect), LILACS (via VHL), and Cochrane databases until March 2022. Observational (cohort, case-control and cross-sectional) and experimental (clinical trials) studies will be included, two researchers’ independents will use the Rayyan QCRI software for retrieval of the articles, in addition, the Mendeley software Reference Manager will be used for reference management. After reading them in ­full, the articles will be selected according to the eligibility criteria. Results: The synthesis of evidence data will be approached from the relationship of consumption of ultra-processed foods and metabolic syndrome in adolescents. Conclusion: Therefore, the importance of this review protocol is highlighted to compose the current evidence on the relationship between consumption of ultra-processed foods and the metabolic syndrome.
Desenvolvimento e avaliação da eficácia clínica de um dermocosmético com princípio ativo nanotecnológico contendo probiótico tópico para tratamento da pele acneica
Authors: Gusmão Flávia Amaral , Badaró Sabrina Lima , Virgens Alane Pereira das
Published: December 2022

A pele e o intestino estão diretamente interligados, quando a microbiota está em desequilíbrio, o organismo fica suscetível à disfunções estéticas, como a acne. Neste contexto este estudo tem como objetivo abordar o uso de probióticos no tratamento da acne através do desenvolvimento de um dermocosmético com princípio ativo nanotecnológico contendo probiótico SynBiotics Bifidum® (Bifidobacterium Lisado). A pesquisa é de carácter experimental e qualitativo, no qual foi realizada a manipulação de um dermocosmético. Para avaliação do controle de qualidade desse estudo foi analisado a estabilidade da formulação, que fornece indicações sobre o comportamento do produto, onde o dermocosmético foi colocado em quarentena por 7 e 30 dias, frente às condições ambientais. Para estabilidade desse produto foi considerada as características organolépticas, físico-química e microbiológica, a fim de garantir uma formulação confiável, segura e eficaz aos pacientes. Foram selecionados 5 estudantes universitários saudáveis com grau de acnes I e II, sendo 4 participantes do sexo feminino e 1 do sexo masculino, ​​entre 20 a 28 anos, no qual foi aplicado um questionário e feito uma consulta individualizada com cada participante. Na análise dos estudos, foi possível observar que a utilização de probióticos nos participantes mostrou efeitos benéficos na saúde da pele, como a melhora da acne, da hidratação e, leve clareamento. A utilização de probióticos para a promoção do bem-estar, prevenção e tratamento de doenças se mostrou relevante, porém a quantidade de estudos sobre esse tema ainda é limitada quando comparada a outros probióticos Bifidobacterium Lisado para tratamento da pele acneica.
Manifestações maxilofaciais da Doença de Crohn: considerações clínicas e odontológicas
Authors: Afonso Áquila de Oliveira , Dallepiane Felipe Gomes , Carneiro Grace Kelly Martins , Gonçalves Heuber de Sales , Braga Marcos Dyllan de Souza , Oliveira Raira Santos de , Pereira Alexandra de Lima , Sena César Vinícius Gato , Lima Marcos Paulo Maia de , Nogueira Brenda Graziella Coêlho
Published: December 2022

A doença de Crohn (DC) é uma doença inflamatória intestinal crônica (DII) do trato gastrointestinal de causa desconhecida. Entretanto, sabe-se que fatores ambientais, epigenética , microbiota intestinal e fatores genéticos são conhecidos pode exercer um papel significativo na etiologia da doença. Assim, esse estudo objetivou revisar a literatura acerca das manifestações orais decorrentes da Doença de Crohn, bem como o manejo adequado para as lesões orais. Como procedimentos metodológicos, adota-se revisão bibliográfica utilizando as bases de dados SciVerse Scopus, Scientific Eletronic Library Online (Scielo), U.S. National Library of Medicine (PUBMED) e ScienceDirect, com auxílio do gerenciador de referências Mendeley. Os resultados indicam que as lesões orais decorrentes da Doença de Crohn incluem o edema labial, edema nodular granulomatoso, ulcerações lineares profundas, mucogengivite, ulceração aftosa, queilite angular e piosestomatite vegetante. O médico dentista deve dar ao paciente a ajuda necessária proporcionando informação sobre as técnicas de higiene e sugerindo o aumento do número de consultas para o controlo das manifestações. Deve realizar interconsultas com o médico gastroenterologista para ajustar o controlo da terapia farmacológica, tudo isto com o fim de proporcionar a melhor alternativa para o paciente e melhorar a sua qualidade de vida.
FORMULATION AND EVALUATION OF PARENTERAL IN-SITU FORMING BIODEGRADABLE IMPLANT FOR CONTROLLED RELEASE OF LEVOTHYROXINE SODIUM
Authors: GOYANİ Manish , SURYAWANSHİ Meghraj
Published: December 2022

Objective: The objective of present research work is formulation and evaluation of parenteral in-situ forming biodegradable implant for controlled release of levothyroxine sodium.
Material and Method: The present study used N-Methyl pyrrolidone (NMP) and triacetin as solvents and PLGA as a biodegradable polymer to manufacture two biodegradable polymeric drug delivery systems, in-situ forming implant (ISFI) and in-situ micro particles (ISM). Other evaluation tests, such as sterility, percent drug entrapment capacity, and so on, were also carried out. ISFI and ISM were tested for up to one month at three different temperatures (4ºC, 25ºC, and 40ºC).
Result and Discussions: The drug release from both systems was compared. The polymer content, type of solvent (hydrophilic or hydrophobic), and implant morphology all contributed to increased burst release in the ISFI formulation. Burst release was decreased using a combination of hydrophilic and hydrophobic solvents (NMP and Triacetin). When compared to other formulations, ISM had the lowest burst release. Both the ISFI and ISM formulations might deliver medications for up to 30 days. Long-acting Levothyroxine sodium formulations (ISFI & ISM) may be a superior option for hypothyroidism treatment.
Keyword: In-situ Implant, Biodegradable polymers, PLGA, Long term release, Solvent exchange technique, ISFI, ISM.
SİPROFLOKSASİN TAYİNİ İÇİN NANOPARTİKÜL TEMELLİ DUYARLI SPEKTROFOTOMETRİK YÖNTEM GELİŞTİRİLMESİ
Authors: BALCI Hakan , ERDOĞAN Zehra Özden , ÖZDEMİR Alperen
Published: December 2022

Amaç: Siprofloksasin, pek çok bakteriyel enfeksiyon ile savaşta kullanılan bir florokinolon grubu antibiyotiktir. Bu çalışmanın amacı, siprofloksasinin spektrofotometrik tayini için nanopartikül temelli hızlı ve duyarlı bir yöntem geliştirmektir.Gereç ve Yöntem: Yöntem geliştirilmesinde metal nanopartikül olarak AgNP kullanıldı. Siprofloksasinin spektrofotometrik tayininde, AgNP’nin 395.5 nm’deki lokalize yüzey plazmon rezonans (LSPR) absorbsiyon bantı kullanıldı. Deneysel çalışmalarda kullanılan fosfat tampon çözeltisinin optimum pH değerini belirlemek için, farklı pH değerlerindeki siprofloksasin-AgNP’nin absorbans değerindeki değişiklikler incelendi. Dinamik Işın Spektrometresi (DLS) ölçümleri ile AgNP boyutundaki değişiklikler tespit edildi.Sonuç ve Tartışma: Çalışmamızda siprofloksasinin farmasötik preparatlarda tayini için AgNP’ye dayalı yeni bir spektrofotometrik yöntem geliştirildi. Geliştirilen yöntem için doğrusal çalışma aralığı, pH 6.0 fosfat tamponunda 0.003-3.313 mg/L ve pH 8.0 fosfat tamponunda 0.025-2.50 mg/L olarak belirlendi. Oftalmik solüsyondaki siprofloksasin miktarının belirlenmesi için yapılan geri kazanım çalışmasında geri kazanım değeri %87±3.3 olarak bulundu. Bu veriler ışığında, siprofloksasin tayini için geliştirilen AgNP bazlı yöntemin klinik analizlerde etkili bir analiz yöntemi olarak kullanılabileceği düşünülmektedir.
Evaluation of Character Education Program in SD IT Nurul Madani Bandar Setia
Authors: Batubara Ropida , Lubis Audy Andini , Pratami Wanda Zuhro Syam , Silitonga Nurhasanah
Published: December 2022

Abstrak

Pendidikan karakter mutlak diperlukan, karena pendidikan pada hakekatnya tidak dapat dipisahkan dari karakter. Tujuan penelitian ini adalah untuk mengevaluasi ketercapaian program pendidikan karakter di SDIT Nurul Madani Bandar Setia. Jenis penelitian adalah evaluasi program (evaluasi formatif) dengan pendekatan kualitatif. Pengumpulan data dilakukan melalui observasi, wawancara dan penelitian kepustakaan. Hasil penelitian menunjukkan bahwa proyek pendidikan karakter termasuk dalam kategori baik. Data dianalisis dengan menggunakan analisis data Milles & Huberman meliputi: reduksi data, penyajian data, dan verifikasi data. Kesimpulan dari penelitian ini adalah: (1) kesiapan sekolah SDIT Nurul Madani untuk mengimplementasikan pendidikan karakter baik, dinilai dari kurikulum yang telah terintegrasi pendidikan karakter, namun masih kurang dalam hal pengelolaan sarana prasarana pendukung dan banyak guru memerlukan lebih banyak pengetahuan dan keterampilan tentang pendidikan karakter; (2) implementasi pendidikan karakter belum tampak pada kegiatan pembelajaran; (3) dukungan dari pemerintah dalam sosialisasi atau pelatihan dirasa masih kurang oleh sekolah; (4) monitoring dan evaluasi pendidikan karakter masih terbatas pada kurikulum dan dilakukan melalui pembinaan pengawas di setiap sekolah; dan (5) kendala yang umum dihadapi sekolah adalah penilaian sikap siswa yang belum terdokumentasi, kurangnya pemahaman guru untuk mengimplementasikan pendidikan karakter, dan tidak adanya sinergi antara pendidikan di sekolah dengan pendidikan di rumah.
Teacher Private Teacher Learning Management Application in SMP IT Nurul Ilmi
Authors: Wati Neli , Khafifah Nanda Putri , Yanti Rina , Riski Alpiq , Ritonga Gunawan
Published: December 2022

Learning management is a very important thing that must be done by every teacher in every educational institution with the aim that a learning process can be structured so that the implementation process can run according to a predetermined plan. The research method used in this study is a qualitative research method where researchers get information from the interview process and documentation as well as observations at SMP IT Nurul Ilmi. The results of a research process carried out at SMP IT Nurul Ilmi got the results that teachers, especially craft teachers at SMP IT Nurul Ilmi carried out the learning process in accordance with predetermined procedures by carrying out a planning and organizing process so that with the existence of a planning and organizing process that carried out by teachers at SMP IT Nurul Ilmi can achieve a predetermined process. The conclusion is that SMP IT Nurul Ilmi has carried out its duties in learning management properly and correctly.
Islamic values planting Model based on Tara, Turu, Toro the Winulu Wakatobi community
Authors: Hamiruddin S. Muh. , Romelah Romelah
Published: December 2022

Eksistensi kearifan lokal, tradisi dan budaya leluhur mulai tergeser oleh budaya modern. Penanaman dan pemahaman nilai-nilai Islam berbasis kearifan lokal menjadi suatu yang penting dan harus diperhatikan oleh berbagai pihak. Penelitian ini bertujuan untuk menggambarkan penanaman nilai-nilai Islam berbasis Tara, Turu, Toro di Komunitas Winulu Wakatobi Sulawesi Tenggara serta mengetahui model penanaman nilai-nilai Islam berbasis Tara, Turu, Toro di Komunitas Winulu Wakatobi Sulawesi Tenggara. Metode penelitian menggunkanan pendekatan kualitatif. Data dihimpun melalui wawancara, observasi dan dokumentasi. Hasil penelitian memperoleh bahwa Penanaman nilai budaya Tara, Turu, Toro dalam pembentukan akhlak dan karakter Komunitas Winulu Wakatobi dimulai melalui 3 cara. Tara, Turu, Toro adalah kesucian, berdiri di jalan yang lurus, dan berpegang pada kebenaran yang tercermin pada 3 perilaku utama yaitu Ma’eka (merasa takut), Mo’ini (merasa malu) dan Rela (merasa ikhlas).
Effectiveness of Economic Token Techniques to Reduce Aggressive Behaviour in ADHD Children in SLBN Merangin
Authors: Epilia Witri , Marlina Marlina
Published: December 2022

ADHD students are developmental disorders, attention disorders and concentration disorders, and cause excessive child behavior. Based on the problem above, students are very prominent in hitting, pushing, and pinching their friends. To reduce aggressive behavior the author uses the token economy technique so that students can reduce the aggressive behavior. This study aims to prove the effectiveness of the use of token economy techniques in reducing the physical aggressive behavior of ADHD children at SLBN Merangin. This type of research uses an experimental method using the Single Subject Research (SSR) research method, the design used is the Multiple-Baseline Across-Behaviors Design. Data collection techniques using observation and video recording. The data analysis technique uses analysis in conditions and analysis between conditions. In the form of graphic analysis, the results of economic research are effective in reducing aggressive behavior in ADHD children at SLBN Merangin.
Learning Interconnection IPS In Elementary School With Modern Century Character Education
Authors: Yusnaldi Eka , Sitanggang Raysyah Putri , Ikhtiati Ikhtiati Ikhtiati
Published: December 2022

Education is primarily a conscious effort to develop the potential of learners optimally. character education, namely; child's personal forms, to become good human beings, citizens, and good citizens, so as to anticipate the symptoms of moral crisis and was instrumental in the framework of fostering the younger generations. Social science Education is a subject that examines the social life of the material is based on the study of history, geography, economics, sociology, anthropology and statecraft. Through learning in the social science can enter the values of character education materials into the handle links in the IPS study
Analysis of Students' Cognitive, Affective and Psychomotor Aspects of Accounting Materials as an Information System Subject of Service Company Accounting Cycle
Authors: Zebua Dedi Irawan
Published: December 2022

This study aims to find out how the level of cognitive, affective and psychomotor abilities of students in learning accounting material as an information system by class XI students of Christian Private Vocational Schools BNKP Gunungsitoli. This type of research is research. The type of data used is a type of quantitative data and the data is obtained by carrying out learning achievement tests on students. The sample in this study were 21 students of class XI at Christian Private Vocational School BNKP Gunungsitoli. To determine the level of affective and psychomotor abilities used observation tables. From the results of the research conducted, it was found that overall students' cognitive abilities in accounting material as an information system were classified as Good material mastery category (71.83%) with a low level of difficulty (28.17%). The level of students' affective abilities is categorized as Good with a score of (74) while the level of students' psychomotor abilities is categorized as skilled with an acquisition of a score (72).
Groundwater Contamination by Wastewater–A Threat for Human–Heath in Punjab Pakistan
Authors:   School of Agricultural, Environmental, and Veterinary Sciences, Charles Sturt University, Albury, NSW, 2640, Australia., Zakir–Hassan Ghulam , Raza Hassan Faiz ,   Irrigation Research Institute (IRI), Irrigation Department, Govt. of the Punjab, Lahore 54500, Pakistan., F Punthakey Jehangir ,   Gulbali Institute, Charles Sturt University, Albury, NSW, 2640, Australia., Shabir Ghulam ,   Irrigation Research Institute (IRI), Irrigation Department, Govt. of the Punjab, Lahore 54500, Pakistan., Ali Hassan Khan Muhammad ,   Ecoseal Pty Ltd, Roseville, NSW, Australia.
Published: December 2022

Increasing population and rapid industrialization are causing continuous increase in wastewater generation. Excessive use of pesticides and fertilizers is also a major threat for land and water pollution. In Punjab province of Pakistan, domestic, industrial, and agricultural effluents are big challenges for many developing countries.
Early Modern Diets against Cancer: The Case of Poultry
Authors:   Faculty of Letters, Translation and Communication Campus du Solbosch–CP 175. Avenue F.D. Roosevelt, 50 1050 Brussels, Belgium., Droixhe Daniel
Published: December 2022

Galenic anti–cancerous dietetics prescribes ‘all types of birds, except those living in marshes’. A general dietary pattern is proposed by Pieter van Foreest and Amatus Lusitanus.
Night Eating: The Light Killer?
Authors:   Chief Highly Distinguished Professor and Scientist, National Elites Foundation, Tehran, Iran, Nikkhah Akbar , Alimirzaei Masoud ,   Behroozi Dairy Complex, Tehran, Iran
Published: December 2022

This perspective article aimed to develop a question if night eating interferes with normal circadian nutrient metabolism in humans. The modern man has tremendously changed his circadian eating time, sequence, and frequency.
Regular Intense Aerobic Exercise May Prevent Obesity, Cancer, and Nervous System Diseases via Novel Gut–Brained Mechanisms
Authors:   Chief Highly Distinguished Professor and Nutritional Scientist, National Elites Foundation, Tehran, Iran, Nikkhah Akbar
Published: December 2022

The human gut is being recognized as a second brain, serving the body for optimal physical and mental health. Obesity and its associated complexities are major health concerns in the modern era.
Implications of Novel Corona Virus–2019 and Perspective of Diet Therapy as an Immune Booster: A Review
Authors:   School of Food and Biological Engineering, Jiangsu University, Zhenjiang, China., Waheed Iqbal Muhammad , Riaz Tahreem ,   School of Food and Biological Engineering, Jiangsu University, Zhenjiang, China., Leghari Ali Ahmad ,   State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122, China., Amin Sabahat ,   National Institute of Food Science & Technology, University of Agriculture, Faisalabad, Pakistan., Shahid Sana ,   National Institute of Food Science & Technology, University of Agriculture, Faisalabad, Pakistan., Mahmood Khan Imran ,   State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122, China., Mahmood Shahid ,   School of Food and Biological Engineering, Jiangsu University, Zhenjiang, China., Yasmin Iqra ,   Center of Excellence for Olive Research and Training, Barani Agricultural Research Institute Chakwal, Pakistan.
Published: December 2022

The unusual rates of morbidity and escalating degrees of mortality in nCV–2019 have compelled the WHO to declare public health emergency of international concern.
Eat Slowly to Beat Bowling
Authors:   Chief Highly Distinguished Professor and Scientist, National Elites Foundation, Tehran, Iran., Nikkhah Akbar
Published: December 2022

This mini–review article highlights the importance of ‘slow eating’ for human protection against metabolic disorders, namely diabetes, obesity, and associated complexities in today’s stressful times. Recent findings suggest that fast eating increases insulin resistance, metabolic syndrome, and weight gain.
Stability Preservation with Simple Suture Technique without Instrumentation in Spinal Tumors: Preliminary Study
Authors:   Department of Neurosurgery, Kahramanmaraş Sütçü İmam University Faculty of Medicine, Kahramanmaraş, Turkey., Altun Idiris
Published: December 2022

Purpose: We aimed to present our experience within similar to laminoplasty with a simple method technique that allows stabilization of the spinal cord without instrumentation during tumor surgery.
Raga Therapy for Autism
Authors:   Department of Pediatrics, University of Illinois, at Chicago, VA Healthcare System, Chicago, IL, USA. Email: nchauhan51@gmail.com, Chauhan Neelima , Kale Mahesh ,   Indian Classical Music and Arts Foundation, Mahesh Kale School of Music, San Francisco, CA, USA. Email: mahesh@maheshkale.com., Naik Neeta ,   EN1 Neuro Services Pvt. Ltd. Mumbai, India. Email: neeta.naik2@gmail.com.
Published: December 2022

Autism spectrum disorder (ASD) is a global health crisis. There is an increasing prevalence of ASD not only in US but throughout the world mainly affecting children and adolescents. ASD exhibits compromised quality of life characterized by persistent deficits in two core areas of functioning including social communication and interaction, and restricted/repetitive patterns of motor activities.
A Brief Notes on Gene Therapy, Cell Therapy and Cell-Based Gene Therapy for Alzheimer’s Disease
Authors:   AllExcel, Inc., 1 Controls Drive, Shelton 06484, CT, USA., Chakraborty Ashok , Diwan Anil ,   AllExcel, Inc., 1 Controls Drive, Shelton 06484, CT, USA.
Published: December 2022

Alzheimer’s disease (AD) is known as an age-related neurodegenerative disease where progressive loss of memory associated with cognition defects has been noticed. Molecular analysis of AD revealed the formation of aggregated amyloid-β protein and hyper phosphorylated tau tangles at the synaptic circuit, which causes the loss of neuronal communication.
EGFR-Mutant Non-small Cell Lung Cancer: State-of-the-Art and Future Perspectives
Authors: Rossi Antonio , Mari Ettore
Published: December 2022

EGFR mutations are the first identified targetable driver alterations in advanced non-small cell lung cancer (NSCLC), for which specific epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKI) have been developed. These small molecules, administered orally, changed the natural history of patients with EGFR-mutated NSCLC, reporting impressive response and survival data.

Osimertinib, a third-generation EGFR-TKI, can be considered the standard first-line therapy for the ‘common’ EGFR mutations, which include the exon 19 deletion and Leu858Arg point mutation in exon 21, accounting for 90% of cases. The ‘uncommon’ EGFR mutations, highly heterogeneous and with a low frequency, seem to be more sensitive to afatinib and osimertinib, a second-generation EGFR-TKI, excluding the EGFR exon 20 insertions mutations, for which a platinum-based regimen should be recommended while waiting for specific targeted inhibitors to reach the market.

However, after an initial activity to first-line EGFR-TKI treatment, a disease progression is reported due to the presence of an intrinsic resistance or the onset of an acquired resistance. The latter can be broadly grouped into EGFR-dependent or EGFR-independent mechanisms of resistance, for which several new drugs and strategic approaches are under investigation.

This review focuses on the state-of-the-art EGFR-TKIs in the treatment of metastatic NSCLC harbouring EGFR mutations, and also discusses potential future perspectives.
Mycophenolate Mofetil-Induced Colitis with Graft Versus Host Disease-Like Features in a Renal Transplant Recipient: Case Report and Literature Review
Authors: Gameiro Joana , Rodrigues Natacha , Melo Maria João , Gonçalves João , Santana Alice , Guerra José
Published: December 2022

Diarrhoea is a common complication after renal transplant and has a significant impact on quality of life, graft function, and mortality. The main causes of post-transplant diarrhoea are infectious and pharmacological. Mycophenolate mofetil (MMF) is an immunosuppressive medication widely used in kidney transplantation patients. Gastrointestinal side effects of MMF, such as nausea, vomiting, diarrhoea, and abdominal pain, mostly occur during the first months of treatment; however, late-onset diarrhoea does not exclude the diagnosis of MMF-induced colitis. MMF-induced colitis is associated with a wide histological spectrum, including inflammatory bowel disease-like, graft versus host disease-like, and ischaemia-like changes, which may lead to misdiagnosis. The complexity and severity of histological features might explain the variation in treatment response. Given the differences in the therapeutic management and prognosis of these histological changes, it is crucial to consider the diagnosis of MMF-induced colitis. The aim of this paper is to report a rare case of late-onset MMF-induced colitis with graft versus host disease-like features in a renal transplant patient who did not respond to MMF therapy withdrawal, and provide a review of data on this rare complication of immunosuppression.
Induction Therapy in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis with Renal Involvement: The Nephrologist’s Point of View
Authors: Salvadori Maurizio , Tsalouchos Aris
Published: December 2022

Renal involvement with rapidly progressive glomerulonephritis is a common manifestation of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides characterised by end-stage renal disease and high mortality rates in untreated and late referral patients. Long-term renal survival has improved dramatically since the addition of cyclophosphamide and, more recently, rituximab in association with corticosteroids to remission induction therapeutic regimens. However, renal prognosis remains unfavourable for many patients and mortality is still significantly higher than in the general population. In this review, the open challenges to be addressed to optimise remission induction therapy, especially in patients with advanced kidney failure, are analysed. This concerns the first-line therapy (cyclophosphamide or rituximab) based on different parameters (estimated glomerular filtration rate at baseline, new or relapsed disease, ANCA specificity, tissue injury, and safety) and the role of plasma exchange. Furthermore, the paper discusses future perspectives on induction remission therapy by reporting recent advances in new targeted therapies, with particular reference to avacopan, an orally administered selective C5a receptor inhibitor.
Prolonged Intravenous Colistin Use Associated with Acquired Bartter-Like Syndrome in an Adult Patient: A Case Report
Authors: Choksi Tatvam , Shah Syed
Published: December 2022

Colistin-induced nephrotoxicity has widely been identified through the elevation of serum creatinine level or a reduction of glomerular filtration rate, but tubulopathy associated with colistin use is poorly understood. Herein, the authors describe a unique case of a 32-year-old quadriplegic male who developed persistent hypomagnesaemia, hypokalaemia, and metabolic alkalosis >4 weeks into therapy with intravenous colistimethate sodium for the treatment of decubitus sacral osteomyelitis by extensively drug-resistant Klebsiella pneumoniae. This required daily aggressive intravenous repletion of electrolytes and fluids while on the treatment, but it was only after 6 days of finishing the treatment with the antibiotic that metabolic changes resembling acquired Bartter-like syndrome started resolving.
Güçlü ve Zayıf Yönlerimi Nasıl Fark Ederim Öğretmen Adaylarının Yansıtıcı Günlüklerden Faydalanarak Girişimci STEM Ders Planları Geliştirmesi
Authors: BOZAN Serhan , KAYA-CAPOCCI Sıla
Published: December 2022

Ekonominin, sosyal standartların artmasının ve bilimsel gelişmenin temeli olarak görülmesinden dolayı, girişimcilik ve FeTeMM yaşamın bir parçası haline getirilmesi önem kazanmaktadır. Bunun için, okullarda ve üniversitelerde açıklayıcı, pratik ve yenilikçi öğretim pratikleri kullanılarak verilecek olan girişimci FeTeMM eğitimine ihtiyaç duyulmaktadır. Bu bağlamda, yansıtıcı düşünme uygulamalarından faydalanılarak öğrenme süreçleri, ön bilgiler, beklentiler ve tecrübeler analiz edilip daha etkili ders planları geliştirilerek girişimci FeTeMM eğitimi desteklenebilir. Üst düzey düşünme becerilerinden birisi olan yansıtıcı düşünme, öğrenme sürecinin değerlendirilmesinde kullanılmaktadır. Bu çalışma, öğretmen adaylarının yansıtıcı düşünme seviyelerini artırmalarına, farklı pedagojik bakış açılarına sahip olmalarına ve ders planlarını geliştirmelerine yardımcı olmayı amaçlamaktadır. Bu nitel araştırma çalışması, Türkiye'de bir devlet üniversitesinde okumakta olan üç tane dördüncü sınıf fen bilgisi öğretmen adayı ile yürütülmüştür. Veriler, yansıtıcı düşünme günlükleri yazılarak ve ön ve son görüşmeler yürütülerek 2021-2022 akademik yılı güz döneminde toplanmıştır. Verilerin analizinde yansıtıcı düşünmenin evreleri olan (a) süreci düşünme, (b) var olan sorunları/problemleri belirleme, (c) bu sorunlara çözüm bulma ve (d) süreci tekrar planlama kullanılmıştır. Verilerin analizi rubrik ve içerik analizi ile gerçekleştirilmiş ve sonuçlar alanyazın göz önünde bulundurularak tartışılmıştır. Bu çalışma yansıtıcı düşünmenin daha etkili ders planı geliştirilme sürecindeki yerine vurgu yaparak ve öğretmen adaylarının daha donanımlı öğretmenler olabilmelerine yardımcı olan tecrübe, mesleki ve alan bilgisi gibi konularda güçlü ve zayıf yönlerinin farkına nasıl varabileceklerine dair önerilerde bulunarak alana katkı sağlamaktadır.