bluuebunny/crossref_metadata_2025 huggingface dataset:
Panorama del manejo de malezas en cultivos de banano en el departamento del Magdalena, Colombia
Authors: Quintero-Pértuz Irma , Carbonó-DelaHoz Eduino
Published: February 2016

En cultivos de banano del departamento del Magdalena el manejo de malezas se realiza, principalmente, mediante la aplicación de herbicidas, cuyo uso intensivo y continuo ha generado la contaminación de fuentes hídricas, sedimentos y ecosistemas marinos, afectando la biodiversidad y la salud humana. Ante la creciente aparición de malezas resistentes a herbicidas y la presión pública por reducir el uso de plaguicidas, es necesario ajustar las técnicas y métodos de control para incrementar la producción, mejorar la calidad de los productos y el bienestar de los agricultores, en armonía con el medio ambiente. Un nuevo enfoque que conciba al cultivo como un agroecosistema y a las malezas como integrantes del mismo, precisa conocer su biología y ecofisiología, así como, la interferencia y pérdidas que ocasionen. En este artículo se describe la situación actual del manejo de las malezas en plantaciones de banano y se discute la necesidad de promover el desarrollo de programas de investigación en malherbología que fundamenten la adopción de técnicas de manejo eficaces y ambientalmente aceptables. 
CYP21A2 gene mutationsin the women with recurrent miscarriage
Authors: Osinovskaya Natalya Sergeevna , Sultanov Iskender Yuryevich , Ivaschenko Tatyana Eduardovna , Baranov Vladislav Sergeevich
Published: February 2016

Miscarriage is one of the major problems of modern reproduction. Total frequency of micarrieges is estimated as 15–27 % of total pregnancies. Recurrent Miscarriage (RM) (three or more spontaneous abortions) is responsible for almost 20 % of total miscarrieges. The population frequency of RM fluctuates from 2 % to 5 %. One of the important causes of abortion in the first trimester are hormonal disturbances in the mother, including adrenal hyperandrogenism, which results in congenital adrenal hyperplasia (CAH). In 95 % of cases, this pathology is caused by mutations in the 21-hydroxylase gene (CYP21A2), encoding for 21-hydroxylase. A non-classical form of CAH is the leading factor in 30 % of RM in women with hyperandrogenia. The aim of this study was to investigate the role of the most common mutations in the CYP21A2 gene in women with RM for more accurate diagnosis of this pathology. The level of 17-OH-progesterone was measured in women with RM and with mutations in the gene CYP21A2. The frequency of mutations in the CYP21A2 gene in RM women was significantly higher than in the group of women who don’t have these mutations (14.4 ± 3.3 % and 2 ± 1.4 %, respectively, p <0,05 df = 1). According to the odds ratio the risk of RM in CYP21A2 mutations carriers is 8 times higher than in the women without these mutations (OR = 8.4 (1.9–37.6)). The level of 17-OH-progesterone is not associated with mutations in CYP21A2 gene in the women with RM
Peculiarity of mitotic activity of chorionic villi cytotrofoblast on the first trimester of pregnancy
Authors: Trofimova Irina Leonidovna , Evdokimenko Eva Valer’evna , Kuznetzova Tatyana Vladimirovna
Published: February 2016

Mitotic activity of chorionic villi cytotrophoblast of the 1st trimester at normal and missed pregnancy was studied. Proliferative activity of cytotrophoblast from missed abortions was somewhat increased in vitro. Application of a semidirect method of chromosomal preparation from chorionic villi is more efficient and provides better resolution for cytogenetic diagnostics of missed abortion. Unusual peculiarity in organization and replication of pericentric heterochromatin regions of chromosomes 1, 9 and 16 was detected
Morphological, biochemical and physiological selection of spermatozoa for ICSI
Authors: Fedorova Irina Dmitrievna , Shilnikova Evgeniya Michailovna , Gzgzyan Alexander Mkrtichevich
Published: February 2016

Principles of individual sperm selection for fertilization were described, literary dates of correlation between morphological, functional and biochemical parameters of human spermatozoa and structural and functional peculiarities of its genome organization were presented
The endometrial implant’s reaction after the experimental mechanical tissue damage
Authors: Aylamazyan Edvard Karpovich , Gzgzyan Alexander Mkrtichevich , Savinov Pavel Alexandrovich , Niauri Dariko Alexandrovna , Dzhemlikhanova Lyailya Kharryasovna , Usoltceva Elena Olegovna , Rad’kova Julia Valer’evna , Savel’ev Artem Vladimirovich
Published: February 2016

Number of experiments for creation of chronic inflammatory response in the implant of autologous endometrium was performing. It turns out, that results, which were morphologically closest to chronic endometritis were obtained after mechanical tissue damage. Endometrial implants with such morphological restructuring might be using for pathogenesis study and for searching of new ways for a treatment of chronic endometritis
Ovaries colony-stimulating factors secretionin patients with infertility in IVF cycles
Authors: Kogan Igor Yu , Motovilova Natalia O , Totolian Areg A
Published: February 2016

This article arrange the data about G-CSF and GМ-CSF content in oocytes follicular liquid infertility patients in IVF and these factors influence for IVF performance
Experience of application of fluorescence methods for diagnostics of cervical intraepithelial neoplasias of different degrees
Authors: Shuliko Larisa Anatolyevna , Dyachuk Alexandr Vladimirovich , Drygin Alexey Nikanorovich
Published: February 2016

The study includes 132 patients with precancerous cervical disease. Along with a standard practice check-up, all the women have undergone photodynamic diagnostic procedure using photosensitizer Photoditazin. The method allows to increase the visibility of the transformation zone of cervical tissue. The results and advantages of the fluorescent cervicoscopy are compared to the traditional methods, with minimal complications and side effects. Diagnoctic effect of the Photoditazin does not depend on the route of administration
Noninvasive prenatal diagnostic. Problems, approaches and perspectives
Authors: Malysheva Olga V , Baranov Vladislav S
Published: February 2016

In the review possibilities of noninvasive prenatal diagnostics on DNA of a fetus circulating in peripheral blood of pregnant woman are discussed. Characteristics cell-free (cf) DNA of plasma and fetus cfDNA (cffNA), circulating in a parent blood-groove are resulted. Methodical approaches to extraction and analysis cffDNA are considered. Possibilities and restrictions of application of a method for fetal sexing and fetal Rhesus factor detection, and also prospect of noninvasive diagnostics of the most frequent aneuploidies are discussed
THE ROLE OF BIOCHEMICAL MATERNAL SERUM MARKERS IN PROGNOSIS OF OBSTETRICAL COMPLICATIONS
Authors: Nikolaeva Yuliya A , Kascheeva Tatyana K , Baranov Vladislav S
Published: February 2016

The article represents the combined results of 1-st and 2-nd trimester maternal serum biochemical markers investigation. Associations of biochemical screening results and the main obstetric complications are studied. Authors critically analyzed the using of biochemical markers of the fetal chromosomal abnormalities as indicators for formation of high risk groups of obstetric complications
Change of indicators of a hemostasis at females with experimental gestosis under the influence of gaba derivatives
Authors: Tyurenkov Ivan N , Ivanova Ludmila B , Karamysheva Victorija I , Lebedeva Svetlana A
Published: February 2016

It is shown that in the conditions of experimental gestosis, induced by replacing drinking water of 1.8% sodium chloride at rats from the first day of gestation until birth, observes disturbances of coagulative properties and augmentation of thrombogenic potential of a blood to what shorting APTT, prothrombin and thrombin time, rising of level of a fibrinogen, hyperaggregation of thrombocytes testifies. GABA-derivative compounds WPC-147, WPC-189 and comparator drug sulodexide show anticoagulant and antiplatelet activity in the conditions of experimental gestosis, extending APTT, thrombin and a prothrombin time, reducing fibrinogen level, reducing platelet aggregation
THE EXPERIENCE OF A STANDARDIZED TECHNIQUE OF LAPAROSCOPIC MYOMECTOMY
Authors: Bezhenar Vitaliy Fedorovich , Tsypurdeeva Anna Alekseevna , Dolinskiy Andrey Kirillovich , Polenov Nikolay Igorevich , Bailuk Evgeniy Nikolaevich , Kakhiani Maka Invirievna , Rusina Elena Ivanovna
Published: February 2016

The aim of this research was to analyze the results of the experience of 85 laparoscopic myomectomy, performed by standardized surgical technique in the Department of Operative Gynecology of Ott Institute of Obstetrics and Gynecology. Developed and describes the main stages of the operation. Analysis of intra- and postoperative complications, duration of hospitalization demonstrated effectiveness and safety of this surgical technique. The most important task of this technique — the formation of a wealthy uterine scar
Sporadic ovarian cancer: the probable model of pathogenesis
Authors: Ashrafyan Leo A
Published: February 2016

This article in question dwells on a possible pathogenetic model ovarian cancer, it’s histogenesis speciality, the role of ovulation, chronic inflammation and stem cells. The scheme of two variant of avarian cancer progress and possible ways of prevention it are represented as well
The AmniSure® ROM test in obstetric management: clinical aspects and economic analysis
Authors: Bolotsky Vyacheslav Mihailovich , Zakharova Vera Yur'evna , Kuzminykh Tat'yana Ul'yanovna
Published: February 2016

The detection of placental alpha-microglobulin-1 in cervicovaginal fluid, as a method to diagnose premature rupture of the fetal membranes, shows high sensitivity and specificity, has economic benefit and can be used in outpatient departments
Impact of the obtained embryos’ quality on the cryopreservation programs outcome in comparison slow freezing method with vitrification in IVF cycles
Authors: Kalugina Alla Stanislavovna , Kravchuk Yana Nikolaevna , Shlykova Svetlana Aleksandrovna , Bystrova Olga Vladimirovna , Kamenetskaya Julia Kazimirovna , Zubova Julia Gennad’evna
Published: February 2016

The objective of this study was to investigate the impact of protocols with agonists and antagonists of gonadotropin-releasing hormone (GnRH) on the quality of obtained embryos and also to compare the efficacy of different methods of embryo cryopreservation — vitrification and slow freezing method. The results revealed, that vitrification method provides better embryo survival rate, higher clinical pregnancy rate. No significant differences between both protocols of controlled ovarian hyperstimulation (COH) were found in the number of embryos of top and good quality
The importance of automized antenatal cardiotocography for assessment of the functional state of fetuses with retarded development
Authors: Kurmangali Zhanar Kuanishbaykizi , Bapaeyva Gauri Billahanovna , Ukibassova Talshyn Muhadesovna , Aimagambetova Gulzhanat Nuratdinovna
Published: February 2016

Application in obstetric practice of automated antenatal cardiotography method allows to eliminate subjectivity and to raise reliability of fetus condition estimation in group of pregnant woman of high obstetric and perinatal risk. It is established that in group of pregnant women with high risk of fetus condition infringement at cardiotocography dynamic supervision reveal already in II trimester. Herewith the earliest and authentic indicators of fetus condition infringement are: decrease variability basal rhythm fetal heart rate, absence of high variability or prevalence episodes of low variability over high, value of STV-short variability indicators less than 4.0. The obtained data allows to recommend application automated antenatal cardiotocography method in group of pregnant women with high perinatal risk for early diagnostics of fetus functional condition infringement. Possibility to estimate severity level of fetus metabolic acidosis will allow to solve in time issues of optimal obstetric tactics in pregnancy conducting, term and a method of delivery at this category of pregnant women
The influence of diffuse toxic goiter on the course and outcome of pregnancy
Authors: Lovkova Yulia Sergeevna , Potin Vladimir Vsevolodovich , Tkachenko Natalya Nikolaevna , Shelayeva Elisaveta Valeryevna , Musaeva Tachira Timurovna
Published: February 2016

We have studied peculiarities of pregnancy, delivery and neonatal thyroid status in 58 women with diffuse toxic goiter. During pregnancy patients received thyreostatic therapy (imidazole and thiouracil derivates). Examination consisted of assessment of levels of free thyroxin, TSH, autoantibodies to TSH-receptors and autoantibodies to thyroperoxidasis in the blood of pregnant women and in umbilical cord blood. The group of comparison consisted of 58 women without thyroid pathology and 111 women with autoimmune thyroiditis. In women with diffuse toxic goiter preeclampsia, chronic placental insufficiency, preterm rupture of membranes, fetal hypotrophy and hypoxia were observed more frequently. 17 % of newborns of mothers with diffuse toxic goiter had subclinical hyperthyroidism and 54% of newborns — subclinical hypothyroidism, depending of transplacental pass of thyreostatic medications
Antiadhesion bariers application in infertil patients with pelvic adhesions
Authors: Popov Alexander Anatolievich , Manannikova Tatiana Nikolaevna , Kolesnik Natalia Alexandrovna , Ramazanov Murad Ramazanovich , Fedorov Anton Andreevich , Barto Ruslan Alexandrovich , Zemskov Urij Vasilievich
Published: February 2016

In article presented results of antiadhesion barrier INTERCOAT™ application after reconstructive surgery in patients with pelvic adhesions related infertility and reproductive outcome
THE PLACE FOR LAPAROSCOPICALLY SURGERY IN THE TREATMENT OF ENDOMETRIAL CANCER (survey)
Authors: Nekrasova Ekaterina Aleksandrovna , Berlev Igor Viktorovich , Urmancheyeva Adel Fedorovna
Published: February 2016

In the treatment of endometrial cancer, which is been the most frequently met oncogynecological disease, basic method remains surgical. Putting into gynecological practice of highly technological operations contributed to the active application of laparoscopy in the treatment of the malignant new formations of endometrium
Atopic dermatitis and pregnancy
Authors: Dombrovskaya Darya Konstantinovna , Kravchenko Elina Vladimirovna
Published: February 2016

The article describes the features of the course of atopic dermatitis during pregnancy. The results of our investigation devoted to the state of the skin barrier in pregnant women with atopic dermatitis and healthy pregnant women are represented. We elucidate the advanced ideas of the feasibility of treatment atopic dermatitis during gestation
Home birth as a way of protection by woman itself and of her child
Authors: Brekhman Grigori Iosifovich
Published: February 2016

The growing obstetrical aggression as aspiration of the doctors actively to operate by labor in a combination with formal attitudes between the woman and accompanying man in labor have given a pulse to occurrence and increase in the world of alternative movement for home birth. From a position of perinatal psychology it could be considered as a display of a woman self-defence and her protection of the unborn child. The author discusses the significance of the mental factor in labor, and also in a choice of a place of delivery. He comes to the conclusion about an opportunity of parallel functioning of two forms of support of the women in labor: in maternity branch of hospital and home under condition of the legislatively authorized Rules about their interaction
The method of stem cells obtaining from menstrual blood
Authors: Aylamazyan Eduard Karpovich , Niauri Dariko Aleksandrovna , Gzgzyan Aleksandr Mkrtichevich , Dzhemlikhanova Lyailya Kharryasovna , Usoltseva Yelena Olegovna
Published: February 2016

The article describes a technique of stem cells isolation from menstrual blood. The characteristics of the obtained stem cells line also present
The usual Comment to clinical Protocol “Hypertension during pregnancy, preeclampsia, eclampsia”
Authors: Aylamazyan Edvard Karpovich , Repina Margarita A
Published: February 2016

The article discusses the principles of classification and therapy of gestosis and hypertension during pregnancy, and contains comments regarding the clinical Protocol published in 2012
Prognostic and predisposing risk factors for perinatal pathology in women with various forms of hyperhomocysteinemia
Authors: Bezhenar Vitaliy Fedorovich , Rusina Elena Ivanovna , Tsuladze Liliya Karlovna , Tsypurdeyeva Anna Alekseyevna , Pavlova Natalya Grigoryevna , Guseva Evgenia Sergeyevna , Maryeva Galina Georgiyevna , Kira Kseniya Evgenyevna
Published: February 2016

In the represented article there has been analyzed the 7-year experience suburethral synthetic slings use in medical treatment of 424 women with incontinence. There has been worked out the diagnostic algorithm of investigation with the aim of making it more exact and choosing the optional method of medical treatment. The estimation of intra- and post- operational complications and the general index of successful sling operations has been revealed. The recommendations have been given for treating patients in case of neuromuscular dysfunctions of the urinary bladder
Prognostic and predisposing risk factors for perinatal pathology in women with various forms of hyperhomocysteinemia
Authors: Guryeva Valentina Andreyevna , Kostkina Yana Mikhaylovna
Published: February 2016

This article shows that folate therapy being carried out since the dispensary registration of women does not prevent the formation of neural tube defects. The determinationof prognostic significance and significance of predisposing risk factors allows predicting the type of hyperhomocysteinemia and its risks. It has been revealed that in case of the congenital form of hyperhomocysteinemia there is a combination with such forms of thrombophilia as the G1691A mutation of the factor V gene (factor V Leiden), the G20210A mutation of the prothrombin gene, PAI-1 gene mutation (5G > 4G). Thus, if congenital hyperhomocysteinemia is diagnosed or may be prognosed, the markers of genetic thrombophiliae should bedetected and the hemostatic system should be investigated. Considering the early formation of defects, the correction, must begin since a pregravid stage, taking into account the detected combinations with changes in the hemostatic system
Influence of herpes virus infection upon the system of hemostasis of pregnant women that have syndrome of usual loss of fetus
Authors: Dolgikh Tatyana Ivanovna , Barinov Sergey Vladimirovich , Kadtsyna Tatyana Vladimirovna
Published: February 2016

There were studied 122 cases of changes at the system of hemostasis of pregnant women that have mixed form of thrombophilia. The research shows the role of active herpes virus infection at the manifestation of the signs of chronic intravascular coagulation within mixed thrombophilia. The results reflect the fact that the complex therapy of mixed thrombophilia starting before the pregnancy provides credible reduction of complications during the pregnancy
Psychological characteristics of pregnant women attending courses of preparation for childbirth
Authors: Bloch Mariya Evgenievna , Shapovalova Elena Andreyevna , Kiselev Andrey Gennadyevich
Published: February 2016

The study of psychological peculiarities of pregnant women attending courses психопрофилактической childbirth preparation, will provide the target correctional work in the process of planning and carrying out the training, thereby optimizing the status of women, both during pregnancy and after childbirth.
Surgical sanitation in complex therapy of acute inflammatory diseases of appendages of uterus in young women: the analysis of typical clinical practice
Authors: Kokhreidze Nadezhda Anatolyevna , Kameneva Natalya Pavlovna , Kutusheva Galiya Fettyakhovna
Published: February 2016

Among recommendations of leading Russian experts on conducting patients with acute inflammatory diseases of appendages of a uterus (AIDAU) the indication to laparoscopic sanitations at young women occurs at availability of suspicion on purulent character of inflammation. Objective: to study of typical clinical practice among gynecologists in definition of readings to surgical sanitation at AIDAU in young women. Methods: the retrospective analysis of 62 cases of repeated hospitalization of 29 patients in the age of from 19 till 37 years. The automated technology of examination of quality of medical aid (QMA) is used. The group of defects QMA «it’s not applied, but it’s shown» in cases of refusal from lapariscopic sanitations are carried out. Results: operative treatment is undertaken at 24.1 % of patients at primary hospitalization and 9,1 % at repeated. In all cases surgical sanitations were undertaken at availability of complications AIDAU. It is established, that at repeated hospitalization the risk organremoving operations reliably increases (р = 0.033). QMA «it’s not applied, but it’s shown» it is revealed in 10,1 % of cases of primary hospitalization and 3,3 % at repeated. Conclusions: Contrary to existing recommendations gynecologists do not undertake a laparoscopy in noncomplicated purulent AIDAU in young not given birth women. Refusal of a surgical component of treatment at 10,1 % of patients with clinical signs of purulent adexitis can be the factor of insufficient efficiency of treatment at primary hospitalization and the reason of recurrent disease in the further
THE MANAGEMENT OF WOMEN WITH THROMBOPHILIA IN PREPARATION FOR IN VITRO FERTILIZATION
Authors: Mirashvili Marina Ivanovna , Zaynulina Marina Sabirovna , Kogan Igor Yuryevich , Gzgzyan Aleksandr Mkrtychiyevich , Rzayeva Roza Nuraddinovna
Published: February 2016

The aim was to study changes in the hemostatic system in women with hereditary and acquired thrombophilia in IVF cycle, the possibility of their drugs correction, as well as the effect of this therapy on the outcome of IVF. We examined 119 women with congenital or acquired thrombophilia during preparation or during IVF cycle. In the presence of abnormalities in laboratory data, combination of weight adjusted dose of the low molecular weight heparin, low dose aspirin and folic acid administered to the severity of coagulation disorders and homocystein level. In the group of patients with a history 3 or more IVF failures APS was diagnosed in 36.6 % of women. In this group the frequency of mutations in genes: PAI-1, PLAT, fibrinogen was significantly higher than in control group (83.3 % and 58.33 %, 40 % and 19.44 %, 50 % and 25 % respectively, p < 0.05), as well as mutations in genes PAI-1 and PLAT combination rate (31.03 % and 13.89 % respectively, p < 0,05) and the frequency of combinations of 3 or more mutations (65.51 % and 19.44 %, p < 0.001). In the group of women with thrombophilia (n = 97) treated with this therapy 52.57 % IVF cycles was successful. At 36.08 % pregnancies ended with childbirth. In the subgroup of women with 3 or more IVF failures (n = 26) the pregnancy rate was 38.46 %.
The functional activity of red blood cells obtained from the healthy infants born through the planned caesarean section operation
Authors: Yakushenko Natalya Sergeyevna , Yevsyukova Inna Ivanovna
Published: February 2016

The erythrogram profiles of the newborn infants delivered both naturally and through the planned caesarean section operation have been studied. Only 40 % of red blood cells have a good functional activity in the premature infants, while in the mature ones, this parameter increases up to 60–70 %. Lower parameters are normally observed with the infants born through the caesarean section operation. The data obtained allows ranking these newborn as a group with high risk of microcirculatory disorders and respiratory distress syndrome, which more endanger the premature infants
Optimization of a cytologic and bacteriological assessment of a pathological secret at chronic duktoforit at women with a mastopatiya
Authors: Guryeva Valentina Andreyevna , Varnakova Ekaterina Suleymanovna
Published: February 2016

The given paper describes high efficiency of detecting chronic inflammation of the mammary ducts (96.2 %) in women with mastopathy by enlargement of cellular composition by means of optimization for the technique of intraductal secretion sampling with the help of mammary duct lavage in comparison with exfoliative method (touch smear) (24.8 %, p < 0.001). The technique of sampling with the help of mammary duct lavage increases detectability of pathogenic flora (82.7 %, p < 0.001) by 2.6 times in comparison with exfoliative method (31.6 %, p < 0.001). It has been established that preliminary sanitation of secerning ducts of a mammary gland prior to ductography increases by 10 times information value for detecting distorting inflammation of the mammary ducts (24.7 %) in comparison with contrast mammography without preliminary ductal lavage (2.5 %, p < 0.001).
THE PECULIARITIES OF CHANGES IN THE STRUCTURE OF PSYCHOEMOTIONAL SPHERE IN WOMEN DURING THE GESTATION FLAVORS OF PREGNANCY
Authors: Znamenskaya Svetlana Ivanovna , Kiselev Andrey Gennadyevich , Shapovalova Elena Andreyevna , Maksimova Irina Mikhaylovna
Published: February 2016

We examined the structure of psychoemotional sphere of 153 pregnant patients in different terms of pregnancy and 48 non-pregnant women. Our data demonstrated that first-term pregnancy is accompanied by a significant emotional stress. In second-term pregnancy those changes are more positive, at third-term pregnancy the level of the patients feels is significantly increased and the psychoemotional sphere is stabilized. Thereby the specific features of nervous system are influence the status of the pregnant women. Evidently pregnant patients with the high level of anxiety, introversion, psychotic and nevrotic characteristics are in need of the increased attention of the obstetric-gynecologic specialists, anaesthesiologists and psychologists to make correction of the psychoemotional sphere when preventive preparation of birth and the choice of anesthesia delivery.
The Immunomorphological condition placentae of the women connected with tobacco smoking
Authors: Zubzhitskaya Lyudmila Borisovna , Semenova Tatyana Valeryevna , Arzhanova Olga Nikolayevna
Published: February 2016

Immunomorphological, histologic research with application of semi-thin cuts bioptats placentae of the women connected with tobacco smoking to pregnancy, during all pregnancy and in the I trimester of pregnancy is carried out. Immunomorphological researches of placentae of studied groups showed that the greatest percent of the revealed fixed pathogenic immune complexes (PEAK) including existence fibrinogen, C3 fraction of a compliment, antibodies and pro-inflammatory citokins, were observed in group of women which smoked all pregnancy. The smallest percent of identification PEAK was in a placenta of the women, stopped to smoke to pregnancy. By parallel kliniko-laboratory comparison it is established that the greatest frequency of complications of pregnancy is observed at women who smoked all pregnancy. At histologic research of placentae of women of studied groups in the field of adjournment the PEAK is observed tsirkulyatorno-dystrophic and necrotic processes. The most widespread changes of a placenta are found at the smokers which pregnancy became complicated the gestozy. In the field of adjournment the PEAK leads damages of membrane structures of a placentary barrier to destructive changes of a placenta, to development of immunopathological process with violation of an immune homeostasis and to development of placentary insufficiency that is adversely reflected in an outcome of pregnancy and childbirth, and also on a fruit and newborn condition.
EVALUATION OF COMBINED NEFOPAM HYDROCHLORIDE AND KETOPROFEN IN THE TREATMENT OF POSTOPERATIVE PAIN IN PATIENTS WITH ENDOMETRIOSIS
Authors: Polushin Yuriy Sergeyevich , Vartanova Irina Vladimirovna , Bezhenar Vitaliy Fedorovich , Korostelev Yuriy Mikhaylovich , Golub Irina Viktorovna
Published: February 2016

Conducted a study to assess the effectiveness of a new centrally acting analgesic nefopam hydrochloride (Acupan). Included 45 patients who underwent laparoscopic surgical treatment of endometriosis of varying severity. Found that pre-emptive analgesia with nefopam and ketoprofen is more effective in patients with endometriosis, I–II severity. In patients with endometriosis stage III application ketoprofen and nefopam significantly improved the quality of postoperative analgesia and reduced the need for narcotic analgesics. In patients with severe endometriosis (IV stage), this scheme was inadequate.
Mesh prostheses in pelvic floor reconstructive surgery in gynecological patients
Authors: Tarabanova Olga Viktorovna , Grigorova Antonina Nikolayevna , Kravtsova Natalya Anatolyevna
Published: February 2016

The results of surgical treatment of 315 patients with genitals prolapse are presented in the paper. Reasonability of utilization of synthetic materials from polypropylene for genitals prolapse correction depending on the operative intervention access and implantable material amount is displayed. Efficiency of urethropexies of trans-vaginal tapings is confirmed by concomitant urinary incontinence of stress genesis.
Particularity of genetic counseling in case of a family carriers of structural aberration of chromosome 6
Authors: Volkov Aleksey Nikolayevich , Olennikova Rimma Vitalievna , Ritenkova Oksana Ivanovna
Published: February 2016

We discuss the case of a family carriers of structural chromosomal aberration del(6)(q24) in two generations. For the first time revealed in 2 year old girl, the aberration has become a reason for family medical and genetic examination, including prenatal cytogenetic diagnosis. The results of clinical and genetic testing of the proband were compared with published data.
Evaluation of violations of vaginal biocenosis in terms of diagnosis and treatment of preinvasive cervical neoplasia
Authors: Berlev Igor Viktorovich , Bakhidze Elena Villevna , Arkhangel’skaja Polina Anatolievna
Published: February 2016

The article analyzes the role of risk factors from the point of view of modern ideas on the viral etiology of precancer and cancer of the cervix. Particular attention is paid to the role of vaginal biocenosis, as a cofactor in the development of preinvasive cervical neoplasia. The results of own studies showing that violation of the biocenosis of the vagina can cause cytological changes similar to the signs of mild dysplasia. It was studied the influence of treatment of vaginal biocenosis on the regression of early neoplastic changes of the cervix.
Hyperhomocysteinemia in miscarriage: biochemical and genetic aspects
Authors: Bespalova Olesya Nikolaevna
Published: February 2016

Elevated levels of homocysteine in the blood is an important marker of the occurrence of various obstetric pathology. As a result of hyperhomocysteinemia impairs processes of microcirculation in the placenta. This in turn can lead to defects of implantation resulting in miscarriage. One of the factors contributing to the increase in the level of homocysteine in the blood is a hereditary predisposition. The purpose of this study is to analyze the influence of gender, age, number of spontaneous miscarriages, the genotype of MTHFR and MTRR genes with folate cycle homocysteine in the blood, the couple with miscarriages.
Status of placental barrier of women at the influence of exogenous and endogenous factors
Authors: Zubzhitskaya Lyudmila Borisovna , Shapovalova Elena Andreevna , Arzhanova Ol’ga Nikolaevna , Dymarskaya Yuliya Romanovna , Lavrova Olga Voldemarovna , Semenova Tatiana Valerievna , Stolpner Elina Georgievna
Published: February 2016

The aim was to study the peculiarities of the placental status of women under the influence of exogenous and endogenous factors. We performed immunohistochemical, histological and immunomorphological study of 384 samples of placenta of women with the most common conditions (asthma, smoking, metabolic syndrome and obesity). We studied the expression of immunohistochemical markers, that indicate the presence of immune inflammation in placenta - CD31, CD35, CD57, CD83, alpha-amylase (α-Amyl) and melatonin receptor 1B (Rc-M-1B), identified C3 complement fraction, fibrinogen, IL-4, IL-6, IL-10, IgA, IgM, IgG. The largest number of immune deposits, fixed in the placenta that damage the the placental barrier (endothelium of vessels of chorionic villi and basal membrane of syncytiotrophoblast) were found in cases of moderate and severe asthma, in cases of who smoked throughout the pregnancy and was more common in cases with metabolic syndrome, while compared with obesity group. We had shown that various antigenic factors influencing on the pregnant woman revealed a similar pathogenetic impact of the pathogenic immune complex (PIC) on the membrane structures of the placenta. Destruction of the membrane structures of placental barrier at the areas of PIC leads to dystrophic and necrotic lesions of the placenta and impaired immune homeostasis, development of immunopathological process and placental insufficiency, which correlates with pregnancy and labour complications, and may be predictors of the possible development of allergic diseases in childhood.
Enterococci and their role in perinatal pathology
Authors: Oganyan Kristina Albertovna , Arzhanova Ol’ga Nikolaevna , Zatsiorskaya Svetlana L’vovna , Savicheva Alevtina Mikhailovna
Published: February 2016

Enterococcus are opportunistic bacteria and are members of the normal microflora of the gastrointestinal tract of humans and animals. The prevalence of enterococcal infections in pregnant women is approximately 28 %. Enterococcus, colonizing the urogenital tract pregnant women mostly do not show pathogenic effect, however, it is known that they can lead to the development of such complications of pregnancy as threatened preterm labor, placental insufficiency, hypotrophy of the fetus. Of complications in childbirth most common in premature labor, untimely discharge of amniotic fluid, fetal hypoxia. According to the literature cause of neonatal bacteremia and sepsis in 10 % of cases are enterococcus. Thus, for the prevention of complications of pregnancy, delivery and perinatal outcomes in the allocation of Enterococcus urogenital tract to undergo antibacterial therapy, given the sensitivity to antibiotics.
Features of oxidative modification of proteins and erythrocyte functional state in pregnancy complicated by placental insufficiency
Authors: Shevelkova Anna Aleksandrovna , Aylamazyan Eduard Karpovich , Evsyukova Inna Ivanovna
Published: February 2016

Protein oxidation intensity and reduced thiols level were studied in comparison with erythrocyte functional state in pregnancy complicated by placental insufficiency. 31 women with placental insufficiency, 41 healthy pregnant and 37 healthy nonpregnant women were included. Induced protein oxidation intensity and reduced thiols level were shown to be decreased in pregnancy complicated by placental insufficiency. Erythrocyte functional state was also worsened. It correlated with protein oxidation intensity and reduced thiols level. So protein oxidation intensity, reduced thiols level and erythrocyte functional state were shown to be indicators of placental insufficiency and can be used to identify this pathology and to evaluate the effectiveness of treatment.
Antiphospholipid syndrome in miscarriage
Authors: Shlyakhtenko Tat’yana Nikolaevna , Alyab’yeva Ekaterina Anatol’yevna , Arzhanova Ol’ga Nikolaevna , Sel’kov Sergey Alekseevich , Pluzhnicova Tamara Aleksandrovna , Chepanov Sergey Vladimirovich
Published: February 2016

Purpose: the frequency of antiphospholipid in patients with reproductive failures was defined. The algorithm of the treatment of these patients was presented. Materials and methods: the study included 2150 patients: 1650 with a history of the repeated pregnancy losses; 450 with sterility and 50 healphy women. Results: the high levels of AFA were founded in 24 % of patients with spontaneous abortions and in 20 % of patients with sterility. Conclusion: Pregravid preparation and permanent monitoring the state of patients reduce frequency of unfavorable ends of pregnancy effectively.
Instrumental methods of diagnosis of ectopic pregnancy
Authors: Ishutina Tatiana Mikhaylovna
Published: February 2016

The article presents a literary review of the capabilities of modern methods of instrumental diagnostics (x-ray, ultrasound, magnetic resonance research) with the assessment of their significance in the diagnosis of ectopic pregnancy with a brief historical digression.
The role of obesity and overweight as a factor of gestational diabetes mellitus: a systematic review
Authors: Kapustin Roman Victorovich , Arzhanova Ol’ga Nikolaevna , Bespalova Olesya Nikolaevna , Pakin Vladimir Stepanovich , Kiselev Andrey Gennadievich
Published: February 2016

Objective: on the basis of a systematic review, clarify the role of overweight and obesity as a predictor of gestational diabetes mellitus (GDM). Materials and methods: an analysis of the literature data of the leading bibliographic sources - MEDLINE, Cochrane col., EMBASE. To evaluate the body mass index and standards of weight gain during pregnancy used the WHO guidelines and criteria of the Institute of Medicine (2009). The frequency and the odds ratio (OR) of developing GDM was estimated separately for each of the three groups in BMI. Results: A systematic review included 23 different design studies involving 740 510 women. It was found that the odds ratio of the risk of GDM in a group of pregnant women with excess weight is doubled - 2.22 (95 % CI 1.72 - 3.64), and almost four in obesity - 3.88 (95 % CI 2.97 - 5.32). The incidence of GDM in a group of pregnant women with normal body mass index - 3.77 % in the group with excess body weight - 6.59 %, in the group with obesity - 9.88 %. Conclusions: The obtained strong evidence of a direct connection between the linear increase in maternal BMI and the risk of developing gestational diabetes. Pregnant women with excess weight and obesity are at high risk for carbohydrate disorders during pregnancy.
The role of active vitamin B12 (holotranscobalamin) in the development of anemia of pregnancy
Authors: Kerkeshko Gleb Olegovich , Dorofeykov Vladimir Vladimirovich , Patrukhina Nataliya Aleksandrovna , Mozgovaya Elena Vital’evna
Published: February 2016

Modern data on the role of vitamin B12, and its biologically active form holotranscobalamin in particular, in the development of anemia of pregnancy are presented. Information on the vitamin B12 metabolism and its coupling with the folic acid and homocysteine metabolism is supplied. The new automated immunochemiluminescent method for the active vitamin B12 determination is described. Reference intervals for the holotranscobalamin and related indices that can be used for the differential diagnosis of anemia of pregnancy are specified.
Neuropsychological and psychometric analysis of the defect at children and adolescents with endogenous mental pathology
Authors: Sergienko Aleksey Anatol'yevich , Strogova Svetlana Evgen'yevna , Zvereva Natalia Vladimirovna
Published: February 2016

This article presents a compound neuropsychological/psychometric analysis of manifestations of defects in children and adolescents with endogenous pathologies. The research was organized among children with diagnosed schizophrenia spectrum disorders: child type schizophrenia, schizotypal personality disorder and other forms of schizophrenia. All patients were on the stationary treatment and had verified diagnosis, defect in cognitive sphere was close to oligofrenic like defect. The experimental group (EG) - 74 children (52 boys), average age - 11,0 ± 2,9 years. Control group (CG) - children and adolescents (64 children, among them 38 boys) from Moscow schools, average age - 11,1 ± 3,0 years. The neuropsychological research was taken on 20 children from EG and on 15 children from CG. Qualitative and quantitative analyses of data included the formulation of criteria of marks of the psychometric and neuropsychological results. Based on our research data we distinguish specific compounds of manifestations of certain cerebrum structure dysfunctions and cognitive dysfunctions that are common in children with schizophrenia spectrum disorders. We also illustrate the differences in localization (in interhemispheric cooperation, cortical structures, subcortical structures) of primary dysfunctions in patients diagnosed with various schizophrenia spectrum disorders. Neuropsychological and psychometric analysis had shown that patients by their functional status are heterogeneous group. The defection of intellectual activity is not total but partial with gradual involvement of different aspects.
Main improvement organizations of federal specialized (oncologic) institute as a unit of health system
Authors: Karitsky Andrey Petrovich
Published: February 2016

Recently economic analysis of health care is demanded and actual due to becoming more and more urgent need for restructuring and a choice of priorities for this boundary section of medicine. In the article are considered strong and weaknesses of health system models, including in option of a so-called transitional economy on the example of federal N. N. Petrov Research Institute of Oncology. Now the N. N. Petrov Research Institute of Oncology can call establishment of national health system with state regulation of programs of general obligatory medical insurance. In this model of health care the state obliges employers and citizens to deduct part of the income on the health insurance, and producers of medical services to provide the population with medical care, including with mediation of insurance companies within obligatory medical insurance. Introduction of this model allowed to provide citizens with full medical care at the expressed reduction of expenses (to 8-12 % of gross domestic product). In the majority of medical institutions medical care is “free”, therefore, to maintain market balance at increase in demand for service, "waiting lists" are entered, patients with “priority” diseases are exposed to treatment, often there are complaints to the unfriendly attitude towards patients. The ideal health system has to provide medical services in unlimited volume without insurance premiums, deductions or individual share at a full freedom of choice of the doctor. Common problem for all systems, mentioning in no small measure functioning of oncologic establishments, is uncertainty of a state role and involvement of each of participants (the state, insurance companies, suppliers of medical services) in realization of various potential functions and problems of health care.
The medical informative systems in pediatric practice - problems and prospects
Authors: Bogdanova Alevtina Viktorovna , Zandakov Cyrendorzhi Valer`evich , Tishkov Artem Valer'evich , Zhelenina Ludmila Alekszndrovna , Sergeev Timofei Vladimirovich , Kuropatenko Mariya Valentinovna
Published: February 2016

Data on the use of modern medical information systems (MIS) in Russian medicine, including in pediatrics are presented. Advances and problems in creating a single unified MIS, diagnostic information systems are highlighted. Information about existing questionnaires in the area of life quality assessment of healthy and patients suffering from pulmonological profile are provided. The problems of diagnostics of chronic diseases of small bronchial tubes at children are observed. It is important to determine the probability of the diseases formation for the usage of financially-based and informative methods of research, aimed at timely identification of the disease are considered. Data of the studies of the prevalence of chronic diseases of the small bronchi of children with the help of specialized questionnaires which were hold in two regions of the Russian Federation are included. The results confirmed the high sensitivity of the methods used and showed a significant excess of the actual prevalence of bronchopulmonary diseases in children compared with statistical data on the uptake. These methods of diagnostics screening have no analogues in pediatrics. MIS with analysis possibility and decision support diagnostic decisions are rather rare, and absent in pulmonary practice. Thus, there is a need for the establishment of unified information systems for diagnostic use in medicine. In particular, in the field of pediatric pulmonology the introduction of an MIS developed on the basis of a proven questionnaire will help to solve the problem of timely detection of chronic allergic and non-allergic respiratory diseases in children in primary care.
Clinical and laboratory criteria of gravity and the principles of treatment of acute infectious mononucleosis, Epstein-Barr virus etiology of the children
Authors: Timchenko Vladimir Nikolaevich , Bannova Svetlana Leonidovna , Fedorova Anna Vladimirovna , Nazarova Anna Nikolaevna
Published: February 2016

The lecture presents the results of many years own research and analysis of the literature on the clinical presentation and therapy of acute infectious mononucleosis, Epstein-Barr viral nature of children. The detailed characterization of the leading clinical syndromes such as fever, intoxication, lymphoproliferative, gepatolienalny syndrome, exanthema. The clinical and laboratory criteria for evaluating the severity of the disease. Principles of drug therapy are presented in accordance with clinical guidelines (treatment protocol) and standards of care for children with infectious mononucleosis. In the treatment leading place etiotropic and immunotropye funds. In pediatric practice, the most widely used and combined antiviral drug viferon immunotropic who appoint 150 000 IU - children up to 7 years, 500 000 IU - children 7-12 years and 1 000 000 IU - children over 12 and adults 2 times per day every 12 hours within 10 days. After a course of therapy with interferon will be a significant reduction in terms of the febrile period and intoxication, difficulty breathing and nasal lymphoproliferative syndrome, a significant reduction in the duration of hospital stay. Viferon also has a positive effect on the speed of the normalization of the hemogram and hemostasis indicators, such as prothrombin time and activated partial (partial) thromboplastin time. Synthesis of endogenous interferon inducers (anaferon children, tsikloferon, derinat) cause prolonging circulars in the blood of its own interferon. Antibiotic therapy is conducted at parenchymatous tonsillitis, taking into account the sensitivity of selected microorganisms. Symptomatic therapy includes the use of fever-reducing, vasoconstrictors, antihistamines. With the development of toxic-allergic rash viferon-apply ointment, gel viferon, allergoferon.