bluuebunny/crossref_metadata_2025 huggingface dataset:
Neuropsychological and neuroanatomical phenotype in 17 patients with cystinosis
Authors: Curie Aurore , Touil Nathalie , Gaillard Ségolène , Galanaud Damien , Leboucq Nicolas , Deschênes Georges , Morin Denis , Abad Fanny , Luauté Jacques , Bodenan Eurielle , Roche Laurent , Acquaviva Cécile , Vianey-Saban Christine , Cochat Pierre , Cotton François , Bertholet-Thomas Aurélia
Published: February 2020

Background

Cystinosis is a rare autosomal recessive disorder caused by intracellular cystine accumulation. Proximal tubulopathy (Fanconi syndrome) is one of the first signs, leading to end-stage renal disease between the age of 12 and 16. Other symptoms occur later and encompass endocrinopathies, distal myopathy and deterioration of the central nervous system. Treatment with cysteamine if started early can delay the progression of the disease. Little is known about the neurological impairment which occurs later. The goal of the present study was to find a possible neuroanatomical dysmorphic pattern that could help to explain the cognitive profile of cystinosis patients. We also performed a detailed review of the literature on neurocognitive complications associated with cystinosis.

Methods

17 patients (mean age = 17.6 years, [5.4–33.3]) with cystinosis were included in the study. Neuropsychological assessment was performed including intelligence (Intelligence Quotient (IQ) with Wechsler’s scale), memory (Children Memory Scale and Wechsler Memory Scale), visuo-spatial (Rey’s figure test) and visuo-perceptual skills assessments. Structural brain MRI (3 T) was also performed in 16 out of 17 patients, with high resolution 3D T1-weighted, 3D FLAIR and spectroscopy sequences.

Results

Intellectual efficiency was normal in patients with cystinosis (mean Total IQ = 93). However the Perceptual Reasoning Index (mean = 87, [63–109]) was significantly lower than the Verbal Comprehension Index (mean = 100, [59–138],p = 0.003). Memory assessment showed no difference between visual and verbal memory. But the working memory was significantly impaired in comparison with the general memory skills (p = 0.003). Visuospatial skills assessment revealed copy and reproduction scores below the 50th percentile rank in more than 70% of the patients. Brain MRI showed cortical and sub-cortical cerebral atrophy, especially in the parieto-occipital region and FLAIR hypersignals in parietal, occipital and brain stem/cerebellum. Patients with atrophic brain had lower Total IQ scores compared to non-atrophic cystinosis patients.

Conclusions

Patients with cystinosis have a specific neuropsychological and neuroanatomical profile. We suggest performing a systematic neuropsychological assessment in such children aiming at considering adequate management.
The Current Status of Radiological Clinical Audit and Feedback on the ESR Guide to Clinical Audit in Radiology and the ESR Clinical Audit Tool (Esperanto) – an ESR Survey of European Radiology Departments
Authors:   European Society of Radiology (ESR)
Published: February 2020

Clinical audit “according to national procedures” is a legal requirement as defined within the recently implemented European Council Basic Safety Standards Directive (BSSD), 2013/59/Euratom. A survey was undertaken in 2019 to assess the current status of clinical audit in European radiology departments and for feedback on the recently published “ESR Guide to Clinical Audit in Radiology” and the “ESR Clinical Audit Tool (Esperanto)”. The survey was distributed within the European Society of Radiology (ESR) EuroSafe Imaging Star network and also to European national radiological societies which are institutional members of the ESR.

A total of 47/116 (41%) EuroSafe Imaging Star departments responded, and responses were received from 43 radiology departments from 16/48 national radiological societies.

Survey findings demonstrated a low awareness of recent key ESR audit-related publications (Esperanto), a lack of clinical audit infrastructure for BSSD compliance and by inference a poorly developed local/national communication and audit infrastructure in many cases.

Key stakeholders, including the ESR and the European national radiological societies, will need to continue to work with other bodies to further promote, integrate and to encourage resourcing of clinical audit at all levels, facilitating BSSD compliance and improving patient care.
Haematological changes in transhumant Baruwal sheep (Ovis aries) grazing in the western Himalayan mountains in Nepal
Authors: Barsila Shanker Raj , Bhatt Keshav , Devkota Badrika , Devkota Naba Raj
Published: February 2020

Transhumance pastoralism is a traditional sheep management strategy adopted by the herders in the Himalayas to address environmental stress. The changes in haematological parameters in the transhumant sheep may well give insights of changes in physiological changes at pasture sites of various elevations in the transhumance cycle. For that purpose, 32 healthy Baruwal sheep were selected and divided into four groups: male (8) below 1 year, male (8) greater than 1 year, female (8) below 1 year, and female (8) greater than 1 year; the animals were selected based on similarity on body weight within the groups. The herd was clinically inspected for the presence of any infection. Adaptation period was set for 3 weeks at each pasture site. The blood samples were taken from designated groups at both grazing sites, i.e. from low (2431 m.a.s.l) to high stopover (3885 m.a.s.l) at the seventh day of the experimental period. Climatic data were recorded at both altitudes over the period of measurements from manually installed weather stations. Later, the herbage species were collected based on the visual sign of grazing at both sites and subjected to chemical composition analysis. The research results revealed that RBC (red blood cell), Hb (Haemoglobin), and PCV (packed cell volume) were significantly increased (p < 0.05) at high altitude, while MCH (mean corpuscular haemoglobin) and MCHC (Mean corpuscular haemoglobin concentration) were higher at low altitude. Sex and age had a similar effect (p > 0.05) on haematologic parameters, except for PCV and MCH. The altitude had a big impact on leucocyte (p < 0.05), being greater at low altitude than high, which could be an indicator of the increased immunologic response at low altitude irrespective of age and sex. The research result revealed the changing haematological responses of Baruwal sheep to changing pasture sites at different altitudes in the transhumance movement. The results further gave a hint of the nutritional stress at low altitude when the herd arrives in the winter season. It is rather difficult to draw an immediate conclusion that pasture quality might be the contributory issue for a decline in the nutritional status of grazing sheep when the herbage species vary by altitude. The measurement of blood metabolic stressors could further facilitate description of the nutritional stress alongside the transhumance when the grazing species and quality are different. Strategic feed supplementation for a much better performance of Baruwal sheep is needed at low altitude to deal with the declined herbaceous quality during winter.
Identification of differentially expressed miRNAs in differentiating benign from malignant pleural effusion
Authors: Bao Quanlei , Xu Yaping , Ding Ming , Chen Ping
Published: February 2020

Background

Tuberculosis pleural effusion (TPE) and malignant pleural effusion (MPE) are very common clinical complications. Considering the totally different prognosis and clinical treatment of TPE and MPE, the accurate and non-invasive diagnosis are very critical for patients with pleural effusion to initiate efficient management and treatment. However, effective clinical biomarkers were rarely explored to distinguish benign from MPE. The purpose of this study is to identify potential miRNAs which can probably be used to differentiate malignant pleural effusion from TPE.

Results

A total of 23 significantly differentially expressed miRNAs were identified in MPE, with 18 up-expressed and 5 down-expressed. And the target genes of the miRNAs mainly involved in the biology process of nervous system, cancer, immune system and metabolic process etc. Three high confident target genes, AGO4, FGF9 and LEF1 can be regulated by miR-195-5p, miR-182-5p and miR-34a-5p respectively. And these genes participate in the canonical pathway of regulation of the Epithelial-Mesenchymal and the biological functions of apoptosis, growth of tumor and cell proliferation of tumor cell lines. Further, RT-PCR validation results based on 64 collected individuals showed that the expression levels of the three miRNAs were 2–5 times higher in MPE samples, which were consistent with the microarray results. In addition, ROC curve analysis demonstrated that the combination of the three miRNAs can achieve higher AUC of 0.93 (p-value< 0.0001) to differentiate MPE from TPE.

Conclusions

The identified miR-195-5p, miR-182-5p and miR-34a-5p can become potential diagnostic biomarkers for MPE with further evidences.
Aligning implementation and user-centered design strategies to enhance the impact of health services: results from a concept mapping study
Authors: Dopp Alex R. , Parisi Kathryn E. , Munson Sean A. , Lyon Aaron R.
Published: February 2020

Background

Innovative approaches are needed to maximize fit between the characteristics of evidence-based practices (EBPs), implementation strategies that support EBP use, and contexts in which EBPs are implemented. Standard approaches to implementation offer few ways to address such issues of fit. We characterized the potential for collaboration with experts from a relevant complementary approach, user-centered design (UCD), to increase successful implementation.

Method

Using purposive and snowball sampling, we recruited 56 experts in implementation (n = 34) or UCD (n = 22). Participants had 5+ years of professional experience (M = 10.31), worked across many settings (e.g., healthcare, education, human services), and were mostly female (59%) and white (73%). Each participant completed a web-based concept mapping structured conceptualization task. They sorted strategies from established compilations for implementation (36 strategies) and UCD (30 strategies) into distinct clusters, then rated the importance and feasibility of each strategy.

Results

We used multidimensional scaling techniques to examine patterns in the sorting of strategies. Based on conceptual clarity and fit with established implementation frameworks, we selected a final set of 10 clusters (i.e., groups of strategies), with five implementation-only clusters, two UCD-only clusters, and three trans-discipline clusters. The highest-priority activities (i.e., above-average importance and feasibility) were the trans-discipline clusters plus facilitate change and monitor change. Implementation and UCD experts sorted strategies into similar clusters, but each gave higher importance and feasibility ratings to strategies/clusters from their own discipline.

Conclusions

In this concept mapping study, experts in implementation and UCD had perspectives that both converged (e.g., trans-discipline clusters, which were all rated as high-priority) and diverged (e.g., in importance/feasibility ratings). The results provide a shared understanding of the alignment between implementation science and UCD, which can increase the impact and sustainability of EBP implementation efforts. Implications for improved collaboration among implementation and UCD experts are discussed.
Predictors of primary patency after percutaneous balloon angioplasty for stenosis of Brescia-Cimino hemodialysis arteriovenous fistula
Authors: Zhu Zheng-Rong , Zou Lan , Xing Yue , Tan Yu-Can , Xu Guo-Jian , He Zhi-Jian , Cao Jian-Qiang , Wu Jia-Yu , Liang Xiao-Xia , Zhang Hui-Ping , Tan Yan-Hong , Luo Can-Hua
Published: February 2020

Objective:

Percutaneous transluminal balloon angioplasty (PTA) is recommended as the first choice to treat stenosis of Brescia-Cimino arteriovenous fistulas (B-C AVFs). The ability to predict which B-C AVFs are at risk for recurrent stenosis post-PTA would allow closer monitoring of patients, and possibly result in surgical intervention rather than repeat PTA. The purpose of this study was to identify predictive factors of primary patency after PTA in B-C AVFs.

Methods:

Patients diagnosed with B-C AVF primary stenosis and treated by PTA between November 2013 and March 2018 were included in the study. Patient and stenotic lesion characteristics and PTA procedure factors were included in the analysis. The Kaplan–Meier method was used to analyze the primary patency rate. Cox proportional hazard regression analysis was used to identify factors predictive of decreased primary patency.

Results:

74 patients (35 males, 39 females) with a mean age of 61.68 ± 11.44 years (range, 36–84 years) were included in the study. The mean B-C AVF age was 16.34 ± 12.93 months (range, 2–84 months), and the median primary patency time was 7.79 ± 0.48 months. Cox proportional hazard regression analysis revealed stenosis location at the inflow artery [hazard ratio (HR)=3.83, 95% confidence interval (CI): 1.46–10.09] or anastomosis (HR = 1.90, 95% CI: 1.09–3.32), dilation >2 times during PTA (HR = 2.30, 95% CI: 1.22–4.34), and residual stenosis >30% (HR = 2.42, 95% CI: 1.26–4.63) were significantly associated with decreased patency.

Conclusion:

In conclusion, the primary patency rate of PTA for B-C AVF dysfunction is reduced by dilation >2 times, residual stenosis >30%, and stenosis located at the inflow artery or anastomosis. These results may help in tailoring surveillance programs, multiple PTA, or a proximal re-anastomosis surgery in patients with AVF dysfunction.

Advances in knowledge:

A number of studies have been conducted to examine the predictors of primary patency after PTA, however, no definitive conclusions have been reached. Our study revealed that stenosis location at the inflow artery or anastomosis, dilation >2 times during PTA, and residual stenosis >30% were the predictors of primary patency after PTA, which may help in tailoring surveillance programs, multiple PTA, or a proximal re-anastomosis surgery in patients with arteriovenous fistulas dysfunction.
The essentials of developmental apoptosis
Authors: Voss Anne K. , Strasser Andreas
Published: February 2020

Apoptotic cells are commonly observed in a broad range of tissues during mammalian embryonic and fetal development. Specific requirements and functions of programmed cell death were inferred from early observations. These inferences did not hold up to functional proof for a requirement of apoptosis for normal tissue development in all cases. In this review, we summarize how the appraisal of the importance of developmental apoptosis has changed over the years, in particular with detailed functional assessment, such as by using gene-targeted mice lacking essential initiators or mediators of apoptosis. In recent years, the essentials of developmental apoptosis have emerged. We hypothesize that apoptosis is predominantly required to balance cell proliferation. The two interdependent processes—cell proliferation and apoptosis—together more powerfully regulate tissue growth than does each process alone. We proposed that this ensures that tissues and cell populations attain the appropriate size that allows fusion in the body midline and retain the size of cavities once formed. In addition, a limited number of tissues, albeit not all previously proposed, rely on apoptosis for remodeling, chiefly aortic arch remodeling, elimination of supernumerary neurons, removal of vaginal septa, and removal of interdigital webs in the formation of hands and feet.
Influence of ultra-small particles (10-20 nm) in the atmospheric air of Chernivtsi during intrauterine development on the course of sepsis in newborns
Authors: Vlasova Olena Vasylivna , Hrytsiuk Mariana Ivanivna , Marusyk Uliana Ivanivna
Published: February 2020

Unfavorable environmental factors that affect parents cause impaired programmed development, the fetus, especially in its sensitive period. Even environmental factors of low intensity due to the bioaccumulation of xenobiotics in maternal tissues and their release to the bloodstream during pregnancy can have a pathogenic effect on the fetus, especially during sensitive periods of its development. To analyze the influence of the content of ultra-small particles (10-20 nm) in the atmospheric air during prenatal development on the course of sepsis in newborns. Based on the results of the analysis of content in the atmospheric air, two clinical observation subgroups were formed. The first subgroup included 17 patients with neonatal sepsis in whom the UFPs content in the air exceeded1.0 inone of the periods. The second subgroup consisted of 35 newborns with sepsis in whom the content of UFPs 10-20 nm in the atmospheric air was less than1.0 inone of these periods. The content in the atmospheric air of ultra-small particles (10-20 nm) during the sensitive period of pre-natal development did not significantly affect the gestational age of newborns, the content in their blood in the presence of sepsis of interleukins-6, -8, -10, pressepsin, procalcitonin, C-RP and immunoglobulins of classes A, G, M, as well as the duration of intensive care and inpatient care.
Current problems of professional training of service specialists
Authors: Hevko Ihor Vasilievich
Published: February 2020

The article is devoted to the current problem of professional training of future specialists in the field of services. The article describes the main features of the organization of professional training of specialists in the service sector, which form a complex of professionally important skills. The possibility of theoretical and pedagogical training of future specialists in the field of services is described. The article emphasizes that professional skills of service professionals have a complex structure and are formed in the process of learning and further professional activity. The high level of professional skills of service professionals will contribute to the development of a highly qualified specialist in the labor market, while respecting all the pedagogical conditions of professional skills formation.
An international focus on cardiac surgery nursing: an introduction
Authors: Sanders Julie , Wynne Rochelle , Martorella Geraldine , Fredericks Suzanne
Published: February 2020

In the ‘International Year of the Nurse and Midwife’, the focus is on celebrating the role of the nurse and highlighting the global burden of disease, as well as how nursing can be influential in strengthening universal health coverage. As cardiac surgery is considered the ‘unborn child of global surgery’, the aim of this six-paper series is to draw together these two important themes: to celebrate the role of nursing in advancing care in cardiac surgery and to provide an international perspective of cardiac surgery nursing.
Enhancing physical assessment skills in the preregistration nursing curriculum
Authors: Richardson Andy
Published: February 2020

This month's issue of BANCC looks at the expansion of physical assessment skills for registered nurses.
Combined Nd:YAG and Er:YAG lasers for real-time closed-loop tissue-specific laser osteotomy
Authors: Abbasi Hamed , Beltrán Bernal Lina M. , Hamidi Arsham , Droneau Antoine , Canbaz Ferda , Guzman Raphael , Jacques Steven L. , Cattin Philippe C. , Zam Azhar
Published: February 2020

A novel real-time and non-destructive method for differentiating soft
from hard tissue in laser osteotomy has been introduced and tested in
a closed-loop fashion. Two laser beams were combined: a low energy
frequency-doubled nanosecond Nd:YAG for detecting the type of tissue,
and a high energy microsecond Er:YAG for ablating bone. The working
principle is based on adjusting the energy of the Nd:YAG laser until
it is low enough to create a microplasma in the hard tissue only
(different energies are required to create plasma in different tissue
types). Analyzing the light emitted from the generated microplasma
enables real-time feedback to a shutter that prevents the Er:YAG laser
from ablating the soft tissue.
Hypertelescope with multiplexed fields of view
Authors: Xie Zongliang , Lepine Thierry , Houllier Thomas , Ma Haotong , Mourard Denis , Labeyrie Antoine
Published: February 2020

Hypertelescope interferometers having many highly diluted sub-apertures are capable of directly imaging, within a narrow field of view, celestial objects at a high resolution thanks to pupil densification. This Letter verifies with OpticStudio modeling the possibility of simultaneously imaging multiple such fields. A strategy of multi-field sampling uses a microlens array to generate multiplexed field channels, where independent active corrections of the tip-tilt and piston are applied for compensating for the off-axis aberrations. Adopting this strategy, we have designed a model of a multi-field hypertelescope with OpticStudio. The reported design expands the observing performance of hypertelescopes for directly imaging multiple sources with very high angular resolution.
Magnetization reversal more rapidly by using an ultrashort square-wave laser
Authors: Zhang Xiaoqiang , Xu Yong , Lian Mingtao , Zhang Fan , Du Yinchang , Lin Xiaoyang , Wang Anting , Ming Hai , Zhao Weishneg
Published: February 2020

With the feature of low-power and ultrashort time magnetization manipulation, all optical magnetic switching (AOMS) has been propelled to the forefront in investigations. To further speed up the magnetization reversal, in this paper, based on the combination of heating and Inverse Faraday Effect (IFE), an ultrashort square-wave laser (USWL) pulse is explored to excite the reversal of magnetization in a Co/Pt system, and all the parameters necessary for our simulation are well within the current theoretical estimates. Simulation results show that the switching time of magnetization is 3 times faster than the using of a traditional ultrashort Gaussian wave laser (UGWL) under the same laser fluence F = 4 mJ/cm2 and pulse duration t0 = 35 fs, and the threshold of AOMS for the ferromagnet is 0.67 mJ/cm2. We furthermore demonstrate that the heat accumulating effect of a laser-pulse is an important factor that influences the switching time, and a USWL has a larger effect of heat accumulating than a UGWL. At present, the debate on the origin of helicity dependent AOMS is still going on, and the model we propose provide a guideline for achieving helicity dependent AOMS more rapidly. We believe that the results could potentially be used to the field of storage technology especially for the using of AOMS.
Pure Small Cell Carcinoma of Prostate in a Patient Presenting with Acute Urinary Retention: A Rare Case Report
Authors: Okçelik Sezgin , Özgün Elmas , Eser Şakir , Polat Mehmet , Temel Muhammed Cihan , Ozcelik Fatih
Published: February 2020

Small cell carcinoma of the prostate is a rare and highly aggressive subtype of prostate cancers. In this case report, we evaluated a patient applied our outpatient clinic with acute urinary retention, whose pathology reported as pure small cell carcinoma of the prostate. A 73-year-old male patient was admitted to our outpatient clinic with acute urinary retention. Digital rectal examination was normal. The PSA value was 1.81 ng/dl. Prostate size was 101 cc. Open prostatectomy was performed. The pathology of the patient was reported as pure small cell prostate carcinoma. Four cycles of etoposide and cisplatin chemotherapy were administered to the patient. The patient died 13 months later after the first diagnosis. We evaluated the pathological and clinical findings of small cell carcinoma of the prostate.
Wybrane regulacje Kodeksu spółek handlowych w świetle konstytucyjnego modelu ochrony własności
Authors: Ochmann Paweł
Published: February 2020

The article confronts specific solutions adopted in the Code of Commercial Compa-nies and Partnerships with the patterns of the constitutional control of law resulting from the Constitution of the Republic of Poland in the form of the right of ownership. Its aim is to answer the question whether the constitutionality of commercial law institutions should be assessed autonomously, taking into account the specificity of commercial companies law. The author puts forward a thesis that just as there is a principle of autonomy of commercial law within the principle of unity of civil law, within the framework of constitutional law, the regulations of law and commerce also have autonomy which influences the process of assessing the conformity of particular subjects of control with the models defined in the Constitution of the Republic of Poland. As one of the specific elements of commercial law in relationto the Constitution, the necessity of weighing the opposing interests of the same good, i.e. the right to ownership is pointed out. The paper discusses in detail the institution of forced buyout (squeeze-out) in the context of the judgment of the Con-stitutional Tribunal (Case No. P 25/02). The issue of legitimacy to appeal against the resolution of the General Shareholders Meeting of a company from the point of view of the right of ownership is also discussed. In the author’s opinion, the right to appeal against the resolution, which prima facie at the constitutional law level could be associated with the constitutional right to a court, takes the form of a corporate right of a shareholder resulting from a constitutional right of ownership, of which a share is one of the forms. Therefore, it has a derivative character. The considerations contained in the text lead to the recognition of the admissibility of an autonomous interpretation of company law regulations when assessing their compliance with the Constitution. When assessing constitutionality, the legal char-acter and specificity of the subject of control should be taken into account.
When Do Start-ups Patent Their Inventions? Evidence from a Broad Approach
Authors: Barrales-Molina Vanesa , Riquelme-Medina Marta , Llorens-Montes Francisco Javier
Published: February 2020

Patents are no longer merely protective; other factors are becoming prominent in explaining when start-ups patent their inventions. This study uses data from 220 start-ups from different industries to evaluate the role of size, location, collaboration partners and financial means in patenting activity. Our results show a quadratic effect of size on patenting likelihood for start-ups, and patenting level reaches a tipping point for medium-sized start-ups. The findings also show that patenting likelihood is higher, regardless of the industry, when: (i) start-ups are located in international clusters or near other start-ups; (ii) start-ups collaborate with specialized research institutes; and (iii) start-ups are financed through crowdfunding campaigns. Location in co-working spaces seems, however, to be associated with lower patenting likelihood. These results help to illustrate the context in which start-ups value patents as protection instruments vs. as strategic resources to achieve other goals, such as reputation, or access to networks or financial capital. Analysing the reasons why start-ups patent is crucial due to the growing relevance these companies gain when they introduce innovations in the current economy.
Reading, seeing and understanding Latin
Authors: Hulstaert Kristien
Published: February 2020

Reading Latin. Easy as it sounds, Latin teachers know it is not. Students are able to analyze words or recognize constructions, yet this knowledge does not enable them toreadand let the Latin words form images in their minds. In order to develop a reading method focusing on the visualization of the story following the Latin word order, an applied research project was set up. The research approach was that of educational design research. Based upon knowledge of word order and colometry, a reading method was developed focusing on the way the story is directed by the Roman author.
Besteuern, wo Werte geschaffen werden – Aufstieg und Niedergang eines Prinzips
Authors: Becker Johannes
Published: February 2020

Wie aus dem Nichts taucht 2013 der Begriff der Wertschöpfung als steuerlicher Anknüpfungspunkt in der Debatte um die Reform der internationalen Unternehmensbesteuerung auf. Der Begriff irritiert die Vertreter der Wissenschaft, inspiriert Politiker und Aktivisten – und ebnet den Weg für eine Reform, die 2020 das internationale Steuersystem grundlegend verändern könnte. Johannes Becker zeichnet die eigentümliche Karriere dieses Begriffs nach, erörtert dessen konzeptionelle Fundierung sowie die steuerpolitischen Konsequenzen und skizziert den aktuellen Reformstand.
La imprescriptibilidad de los crímenes internacionales: contornos, lagunas y perspectivas
Authors: Dondé Matute Francisco Javier
Published: February 2020

En el presente texto se analizan y sistematizan las diferentes variables que existen en la imprescriptibilidad de los crímenes internacionales. Derivado del estudio se concluye que la imprescriptibilidad de estos crímenes no es una regla absoluta porque si bien esta figura se aplica sin reservas en los delitos establecidos en el Estatuto de Roma, en el caso de la desaparición forzada y la tortura existen menos argumentos para sustentar la imprescriptibilidad de estos tipos penales.
Los usos y costumbres en Tlaxcala: un ir y venir histórico
Authors: Mateos Gómez Gabriela Georgina
Published: February 2020

Tlaxcala, previo al México colonial, estaba estructurada en cuatro señoríos que gozaban de autoridad en sus comunas y que se reunían para discutir lo relativo a todos ellos. Con la alianza que se hizo con España, Cortés les ofreció participar en la dominación de Tenochtitlán, respetar su autonomía, formas de gobierno y adoptar la religión católica. Por ello, en Tlaxcala la organización municipal se conforma en un sistema jurídico que contiene dos sistemas electorales: uno constitucional y otro consuetudinario —Usos y Costumbres—, legitimado 1995.
Apuntes sobre la procedencia del juicio de garantías contra actos del notario actuando como particular en funciones de autoridad
Authors: Hernández Hernández Fabián
Published: February 2020

En este artículo me propongo estudiar la función del notario público como manifestación del ejercicio de un poder que en ciertas condiciones puede crear, modificar o extinguir situaciones jurídicas concretas de trascendencia para los particulares, por lo cual, en esos casos, los actos derivados del ejercicio de la función notarial podrán ser objeto del juicio de amparo. En ese sentido, propongo una teoría excepcional positiva de la procedencia del amparo, siempre que se considere al notario como un particular en ejercicio de las funciones de la autoridad, lo cual supone reconocer una cierta concepción de los derechos humanos y del Estado constitucional.
Grave human rights violations and crimes against humanity under public international law: The case of Mexico
Authors: Estrada-Tanck Dorothy
Published: February 2020

The UN international legal framework on grave human rights violations and crimes against humanity has developed in recent years, to the degree of an initiative for an autonomous treaty on crimes against humanity. Mexico has undergone several Constitutional and legal reforms accepting the priority and legal supremacy of international human rights instruments but confronting one of the worst humanitarian crises of its history. This article reviews the relationship between international law in this area and the specific factual, legal and methodological problems and efforts undergone by different actors in Mexico and proposes ways to step closer to fulfilling victims’ internationally recognized rights to truth, justice and reparations.
La justicia transicional como mecanismo de reconciliación en el Estado colombiano
Authors: Hernández Ramírez Mildre Yurani
Published: February 2020

El presente artículo tiene por objeto analizar la implementación de la justicia transicional como mecanismo de reconciliación, a través de procesos judiciales y extra­judiciales, establecidos en el acuerdo final para la terminación del conflicto y la cons­trucción de una paz estable y duradera, pactado entre el Gobierno Nacional Colombiano y el grupo armado FARC-EP (fuerzas armadas revolucionarias de Colombia – ejército del pueblo), con la finalidad de reemplazar un estado de guerra civil, por un orden social pacífico de mediación. Particularmente, el diseño de cada Estado, refiriéndonos al co­lombiano, en donde se concilia el deber supremo de la memoria histórica, la reconstruc­ción de la ciudadanía, la nación y el mercado con la justicia.
Avances en el reconocimiento del derecho humano a la identidad de género auto-percibida en México
Authors: Ortiz Miguel Angel León
Published: February 2020

El presente trabajo tiene como objetivo primordial identificar varios aspectosinteresantes sobre el origen del fenómeno transexual en la historia contemporánea; de notoria influencia en la labor jurisdiccional nacional e internacional a través de la resolución de ciertos casos que han impactado la regulación de varios países. Desde el 2012, Argentina se convirtió en el primer país en el mundo en adoptar el criterio no patológico de las vivencias trans (que se registró por primera vez en los principios de Yogyakarta de 2006) con la publicación de la Ley No. 26743 de Identidad de Género, marcando una tendencia vanguardista en la garantización de los derechos de las diversidades de género en otros países del mundo que han elaborado disposiciones similares, incluyendo a México.
Non classic presentations of a genetic mutation typically associated with transient neonatal diabetes
Authors: Devaraja Janani , Elder Charlotte , Scott Adrian
Published: February 2020

This case report describes a family pedigree of a mother and her children with an E227K mutation in the KCNJ11 gene. People with this particular gene mutation typically present with transient neonatal diabetes; with more than half the cohort relapsing into permanent diabetes in adolescence or early adulthood. However, the mother developed diabetes as an adolescent and thus was initially diagnosed as having Type 1 Diabetes. All her children have inherited the same genetic mutation but with differing presentations. Her second, third and fourth child presented with transient neonatal diabetes which remitted at varying times. Her first child is 16 years old but had not developed diabetes at the time of writing. The KCNJ11 gene codes for the KIR6.2 subunit of the KATP channels of the pancreatic beta cells. Mutations in this gene limit insulin release from beta cells despite high blood glucose concentrations. Most people with diabetes caused by this genetic mutation can be successfully managed with glibenclamide. Learning of the genetic mutation changed the therapeutic approach to the mother’s diabetes and enabled rapid diagnosis for her children. Through this family, we identified that an identical genetic mutation does not necessarily lead to the same diabetic phenotype. We recommend clinicians to consider screening for this gene in their patients whom MODY is suspected; especially in those presenting before the age of 25 who remain C-peptide positive.

Learning points:

KATP channel closure in pancreatic beta cells is a critical step in stimulating insulin release. Mutations in the KIR6.2 subunit can result in the KATP channels remaining open, limiting insulin release.

People with KCNJ11 mutations may not present with neonatal diabetes as the age of presentation of diabetes can be highly variable.

Most affected individuals can be treated successfully with glibenclamide, which closes the KATP channels via an independent mechanism.

All first degree relatives of the index case should be offered genetic testing, including asymptomatic individuals. Offspring of affected individuals should be monitored for neonatal diabetes from birth.

Affected individuals will require long-term follow-up as there is a high risk of recurrence in later life.
Security Measures In Ukraine’ Criminal And Criminal Procedure Law
Authors: Shpiliarevych V.V.
Published: February 2020

The article is dedicated to the study of security measures in criminal and criminal procedural law of Ukraine. Determined by the influence of integration and globalization processes, there is a tendency of convergence of various branches of law, including criminal and criminal procedural law. Therefore, the implementation of a modern effective policy in the field of crime prevention in Ukraine requires an improvement of existing preventive measures and development of new ones, both at the international and national levels. That is why, criminal and criminal procedure measures, namely security measures, play an important role in ensuring the protection of a person's interests against internal and external threats.

In particular, criminal-law security measures should be understood as a variety of measures of criminal nature, provided by the Criminal Code of Ukraine, which appliedn to a person, which is in «dangerous state», on behalf of the state on by reasonable court decision, in order to prevent the re-committing of a socially dangerous act, which predicted by the Special Part of the Criminal Code of Ukraine.

From a criminal procedural point of view, security measures (measures to ensure the safety of participants in criminal proceedings) - is the implementation of legal, organizational, technical and other measures aimed to protect life, health, housing, property, honor and dignity of a person against unlawful attacks, in order to create the necessary conditions for the proper administration of justice.

As a conclusion, the author states that the security measures existing in the criminal law of Ukraine differ from the security measures of criminal procedural character, by its nature, system, subjects to which such measures are applied, the purposes and aims of its application.
Retrospective Bankruptcy Legislation In The Practice Of The European Court Of Human Rights And Constitutional Court Of Ukraine
Authors: Sabodash R.B.
Published: February 2020

The paper focuses on the debtor’s contract awarded into a suspicious bankruptcy period. Special attention is paid to retrospective bankruptcy legislation according to which the debtor’s contracts may be declared invalid.

The article deals with the practice of the Supreme Court, the Constitutional Court of Ukraine, the European Court of Human Rights. The European Court of Human Rights in the case «James and Others v. The United Kingdom» stated that the fairness of a system of law governing the contractual or property rights of private parties is a matter of public concern and therefore legislative measures intended to bring about such fairness are capable of being «in the public interest», even if they involve the compulsory transfer of property from one individual to another.

Special attention is paid to cases “Melnyk v. Ukraine” in which the European Court of Human Rights requires retrospective civil legislation is not expressly prohibited by the provisions of the Convention and in certain circumstances may be justified. Therefore, the Court considers that the issue of an effective remedy is concerned, the remedy in question must already exist with a sufficient degree of certainty. The retroactive application of civil procedural law would undermine the principle of legal certainty and would be contrary to the rule of law when it deprives a person of access to a remedy which is deemed to be effective for the purposes of Article 35 § 1 of the Convention.

The issue of this paper is to show that the aim of the legislation could not have been achieved without retrospection and the author is accordingly satisfied that a reasonable degree of proportionality exists between the means employed and the aim sought to be achieved because each party has access to effective remedies.
The Institute Decision Of Land Disputes In The System Of The Land Law
Authors: Yaremak Z.V.
Published: February 2020

The article deals with the theoretical and legal research of the Institute of Land Disputes as a separate type of land legal relations. The modern scientific concepts of understanding the legal nature of the settlement of land disputes in the science of land and environmental law are analyzed. It is concluded that the legislative consolidation of the settlement of land disputes as a guarantee of land rights determines the peculiarities of determining the content of this legal category as a type of land legal relations, regulated by the rules of land legislation.

On the one hand, as a guarantee for the protection of human rights, the resolution of a land dispute is viewed through the prism of its effectiveness, which is ensured (implemented) with the help of public authorities within the powers defined by law to make a decision that will restore the violated, unrecognized or contested right. On the other hand, the settlement of land disputes is seen as a kind of land management relations of procedural content.

On the basis of a systematic analysis of the provisions of the Land Code of Ukraine, it is concluded that Section V of the Land Code of Ukraine contains only legal guarantees for the protection of land rights, not guarantees for land rights, and leaves out the guarantees of realization and protection of land rights, which are defined outside this section.

The urgent issue remains the effectiveness of resolving land disputes and strengthening its importance as a guarantee for the protection of land rights. This raises practical problems of differentiation of competence, efficiency of procedures of consideration of cases and execution of decisions in land disputes. The lack of quality legal regulation causes the settlement of land disputes as a guarantee for the protection of land rights not receiving proper practical implementation and to some extent being declarative.
Lęk przed Bogiem, śmiercią i Szatanem w dawnej Rzeczpospolitej (XV – XVIII w.)
Authors: Leszczyński Seweryn
Published: February 2020

brak
Kolonizacja i chrystianizacja a teatr – spojrzenie z perspektywy XX i XXI wieku
Authors: Delimata Maria
Published: February 2020

brak
Uczelnie wyższe a idea ustawiczności kształcenia
Authors: Marcinkiewicz Aleksandra
Published: February 2020

brak
Teatr tańca – dzieje pojęcia
Authors: Iwańska Alicja
Published: February 2020

brak
Krytyka sarmackiego ucztowania oparta na fragmentach tekstów literackich i piśmienniczych autorów dawnych
Authors: Orman Eliza
Published: February 2020

brak
Inny hellenizm. Obrazy Bizancjum w literaturze młodopolskiej
Authors: Szmid Kamil
Published: February 2020

brak
Debata nad związkiem poezji i polityki w Pamięci W. B. Yeatsa W. H. Audena i Elegii przed wojną A. Ostriker
Authors: Marecki Mateusz
Published: February 2020

brak
Ciało, duch i płeć w poezji Marii Komornickiej
Authors: Lisowska Katarzyna
Published: February 2020

brak
Sztuka, postsztuka, autosztuka i ...
Authors: Wnuk Kamil
Published: February 2020

brak
RESEARCH ON THE PHYSICOCHEMICAL COMPOSITION OF BLACK BLUEBERRY AND BLACK CURRANT USED AS THE SOURCES OF BIOLOGICALLY ACTIVE SUBSTANCES IN MAKING FUNCTIONAL BEVERAGES
Authors: Stefanova Radostina , Georgieva Antoaneta , Krastev Krasimir
Published: February 2020

The physicochemical composition of the dried fruits Vaccinium myrtillus L. and Ribes nigrum L. was investigated in order to use them as a raw material for the production of functional drinks.
In the course of the work it has been found that berries are a valuable raw material for the production of plant extracts for the production of functional drinks.
They are the source of many biologically active substances such as vitamins, polyphenolic compounds and pigments.
SPECIFIC LEGAL CHARACTERISTICS OF THE CARDS FOR RESTORED PROPERTY OF AGRICULTURAL AND FORESTRY TERRITORIES
Authors: Velkovski Valeri
Published: February 2020

The maintenance of the map of the restored property as specified in the text of Article 15, paragraph 1 of Ordinance No 49 for the maintenance of the card of the restored property [www.ciela.net] [2] shall be carried out by the Municipalities of Agriculture by land.
An essential point reflected in the text of Article 30 of Ordinance No 49 [2] is the legal requirements for the numbering of the properties subject to a map of the restored property.
Each landed property is designated with a specific number.
The characteristic of this number is that it cannot be repeated with another property number on the territory of the country.
The estate number is also the number of newly formed property under a project for consideration or consolidation of a land property.
The sketch of the project for partitioning, splitting or merging of properties is made by the contractor of the technical activities for maintaining a map of the restored property, determined by the order of the Public Procurement Act [www.ciela.net] [7].
The sketch should contain ten items, nine technical and one administrative.
CHARACTERIZATION OF RUBBER-LIKE MATERIAL OBTAINED FROM WASTE BIODIESEL
Authors: Georgieva Krasimira , Denev Yordan
Published: February 2020

A new polymeric material as result from long term polymerization of waste biodiesel was synthesized. The rubber-like material was produced for six years storage in open container at normal conditions and air presence. The block synthesis of rubber materials may be very useful comparing with the expensive emulsion and solution processes used in the rubber industry. The nature of the new material, called by authors Nanifam, can be described definitely as polyacrylate rubber in oligomeric state and density of 0.95 kg/m3. Polyacrylate rubbers have significant usage in the polymer industry. They have very strong resistance to oils and solvents as well as good behaviour at high temperatures (up to 150 - 200 oC). The most popular application of this rubber is as insulations and protective coatings. The identification of invented by spontaneous polymerization reaction rubber was carried out using standard chemical techniques, color analytical reactions and FT-IR spectroscopy as a primary structural instrumental method. The peaks in registered spectra of new polyacrylate rubber have typical shape and wave numbers described polymer with hydrocarbon chain (-CH2-CH-), carbonyl groups (-C=O) and typical functional acrylate groups. The results from reaction of Liebermann-Morawski definitely show behaviour similar as poly(chloroprene) rubber and poly(isoprene) rubber. The aim of present work is study on the full spectroscopic characterization of a new rubber material with polyacrylate nature and proving of the possibility for producing in block from waste biodiesel of this new polymer.
The vicarage farm incident – a precautionary tale
Authors: Harding Neil
Published: February 2020

The Vicarage Farm Reservoir incident involved an emergency draw-down of the reservoir, but also involved some serious personal safety issues for the supervising engineer. The paper describes how the structural integrity of the dam was compromised and the actions taken to mitigate the potential consequences, illustrating the roles of the different people and organisations involved. The paper concludes with an overview of some of the issues that can influence or affect safety, primarily of a personal nature but also some environmental topics. It suggests that increased awareness or formal training should be considered for panel engineers to broaden and develop their abilities.