bluuebunny/crossref_metadata_2025 huggingface dataset:
DEFINITION OF VASICULAR AGE AS A RISK FACTOR FOR CARDIOVASCULAR COMPLICATIONS
Authors: КАПСУЛТАНОВА Д.А. , ЗКРИНА А.М. , САБЫР Н.М. , БАЙМОЛДА А.Е. , КАДЫРЖАНОВ М.Н. , ЕСЖАН Н.Т.
Published: August 2021

По данным ВОЗ с каждым годом частота сердечнососудистых осложнении (ССО) увеличивается. На это воздействуют множество факторов, немаловажным среди которых является недооцененный риск ССО пациентами. Так как разное понимание степени риска приводит к различной приверженности к лечению. Для интерпретации риска в более понятную как для врача, так и для пациента форму, составили различные методы оценки риска. Одним из методов является определение сосудистого возраста. Данная статья изучает сосудистый возраст, 5летний риск развития сердечнососудистых осложнений (ССО), коэффициент атерогенности и скорость клубочковой фильтрации (СКФ) у пациентов, страдающих артериальной гипертензией (АГ), с наличием и отсутствием нефропатии.

According to the WHO, the frequency of cardiovascular complications (CVD) increases every year. This is influenced by many factors, not least of which is the underestimated risk of CVD by patients. Since different understanding of the degree of risk leads to different adherence to treatment. To interpret the risk in a more understandable form for both the doctor and the patient, various methods of risk assessment were developed. One of the methods is to determine the vascular age. This article examines vascular age, 5-year risk of cardiovascular complications (CVD), atherogenicity coeficient, and glomerular filtration rate (GFR) in patients with arterial hypertension (AH), with and without nephropathy
REHABILITATION AFTER CORONAVIRUS INFECTION
Authors: Даурбай Ж.Н. , Абдулла Р. А. , Мырзахмет Б. Е. , Абдыкалы Е. К.
Published: August 2021

Миллионы людей по всему миру заболели коронави русом нового типа. Согласно многочисленным исследованиям, осложнения Сovid-19 вызывают легочный фиброз. В начале эпидемии, например, было неясно, обратимы ли эти изменения или нет. Во всем мире, в нашей стране, во всех санаториях внедрены новые реабилитационные программы для пациентов, инфицированных коронавирусом. Дыхательные упражнения, терренкуры, плавание, специальные диеты, соляные пещеры все это помогает восстановить дыхание.

Millions of people around the world have contracted a new form of the disease, coronavirus. According to numerous studies, complications of covid-19 cause pulmonary fibrosis. At the beginning of the epidemic, for example, it was unclear whether these changes were reversible or not. All over the world, in our country, all sanatoriums have introduced new rehabilitation programs for patients infected with coronavirus. After all, it is very important to fight this virus, as well as to recover after getting sick with this virus. Breathing exercises, terrenkurs, swimming, special diets, salt caves all this helps to restore the respiratory system.
IMPACT OF COVID-19 ON THE PSYCHO-EMOTIONAL STATE OF THE POPULATION OF KAZAKHSTAN
Authors: ДУИСЕМБАЕВА Б.С. , ТУРСЫНАЛИ М.Б. , ДУЙСЕМБАЕВА А.Т.
Published: August 2021

Проведен анализ данных онлайн анкетирования во время ЧС положения в Казахстане. Выявлено, что проведенное нами анкетирование среди населения Казахстана находящихся во время ЧП дома (общая группа 152 человека) позволило сделать заключение о том, что режим ЧП в Казахстане повлиял на психоэмоциональное состояния населения. Больше подвержены к стрессу были женщины, чем мужчины. Это говорит, нам статистика опрошенных. Это связано тем, что дома оставались в большинстве случаях женщины. Молодежь остро реагируют на стресс, это можно объяснить тем, что у них мало жизненного опыта. Изменения привычного образа жизни, повлиял на все слои населения

The analysis of the data of online questioning during the state of emergency in Kazakhstan was carried out. It was revealed that our questioning among the population of Kazakhstan who were at home during the state of emergency (total group of 152 people) allowed us to conclude that the state of emergency in Kazakhstan has affected the psycho-emotional state of the population. Women were more susceptible to stress than men. This is what the statistics of those interviewed tell us. This is due to the fact that in most cases women stayed at home. Young people react acutely to stress, it can be explained by the fact that they have little life experience. Changes in the habitual way of life, affected all segments of the population.
IS IT NECESSARY TO DEVELOP THE PHYTO-MARKET IN KAZAKHSTAN?
Authors: НУРАЛИЕВ Г. Б. , БАБАЕВА А. А.
Published: August 2021

Растения имеют долгую историю использования в качестве традиционных средств для лечения ряда заболеваний, и различные химические вещества, которые они производят, на сегодняшний день послужили большим вдохновением для разработки новых лекарств. Многие растения еще предстоит исследовать на наличие биологически активных продуктов. Мы подчеркиваем важность создания и развития фиторынка в Казахстане.

Plants have a long history of use as traditional treatments for a range of diseases, and the various chemicals they produce have served as great inspiration to the development of new drugs to date. Many plants have yet to be tested for bioactive products. We emphasize the importance of creating and developing the phyto market in Kazakhstan.
OPTIMIZING DEMOGRAPHIC DIVIDEND IN PERSPECTIVE OF RETURN ON EDUCATION IN EAST JAVA: TO SCHOOL, TO WORK, OR TO ENTREPRENEUR?
Authors: Herlambang R. Dimas Bagas
Published: August 2021

Human capital highly affects economics productivity. Thus, education plays an important factor in every demographic dividend. This study will estimate the return on education to paid-employment and self-employment in East Java using SAKERNAS 2012. Using Mincerian specification and Sohn model, this study analyzed the baseline model and to analyse further in self-employment. This study will also compare result in East Java with National and other Java province. Results from estimation found that return on education in East Java is generally higher than national, but lower than West Java. As for self-employment, return on education in East Java is lower than paid-employment, but in the lowest magnitude if compared with National and other Java region. Labor market flexibility that analyzed in this study also shows that East Java relatively more flexible. As a matter of opportunity cost, the low return rate of education in East Java demand some adjustment in education and labor market policy to optimize the economic outcome.
FORMATION OF COMPOSITE GLOBAL COMMODITY PRICES AS AN INFLATION INDICATOR FOR EAST JAVA
Authors: Cahyaningrum Anisha Wirasti
Published: August 2021

With the average contribution of imports to Gross Regional Domestic Product (GRDP) in the last five years reaching 19.1%, the dynamics of global commodity prices also influence the economic performance of East Java, including the movement of inflation. A composite indicator of global commodity prices is needed to find out the impact of changes in various global commodity prices on inflation in East Java. By adopting the Bank Indonesia methodology in forming a composite global price known as the Imported Inflation Price Index (IHIM) which has considered the method of forming a global composite price created by the IMF (IMF Commodity Price Index), the compilation of East Java global price composites also examines the accuracy of commodity selection and aspects of data availability. The selected global price composite for East Java is a composite of seven global commodities which include food (wheat, soybeans, corn and CPO) and non-food (iron, gold and oil). These are two aspects determining the relative weight, namely (I) the import portion of the total input based on the Input-Output table and (ii) the commodity weight of derivatives in the East Java Consumer Price Index (IHK) basket. Furthermore, with OLS regression, the composite of East Java global commodity prices affects the core-traded inflation movement in East Java. Thus, the composite of global commodity prices in East Java can be used as an indicator of East Java inflation projections, especially core-traded inflation. This study, in general, will also examine the effect of the exchange rate impact on the movement of core inflation, especially traded groups in East Java. Based on the regression results it is known that the impact of the exchange rate movement on core traded inflation in East Java is more significant than the effect of world commodity price movements.
Rage furieuse de l'enfant transmise par un chat errant : à propos d'un cas et revue de la littérature
Authors: Savadogo Mamoudou , Boushab Mohamed , Fall-Malick Fatima Zara , Sondo Apoline , Kyélèm N
Published: August 2021

La rage est une zoonose grave qui sévit dans la plupart des pays en développement. Elle est transmise généralement par le chien enragé mais exceptionnellement le chat peut être source de contamination de la maladie. Nous rapportons un cas de rage furieuse transmise par un chat errant, survenu chez un enfant. Le tableau clinique s'est installé 45 jours après une morsure et griffure par un chat errant alors que l'enfant était parti tôt le matin pour ses besoins derrière une concession abandonnée. La symptomatologie se résumait à une agitation psychomotrice, des hallucinations, un délire, une photophobie, une hydrophobie, une hyperesthésie cutanée, une détresse respiratoire et une déshydratation modérée, le tout évoluant dans un contexte fébrile.  Sous traitement symptomatique, il décéda 48 heures après son admission.

Il ressort la nécessité de sensibiliser les populations et le personnel de santé sur le risque rabique après une exposition à une morsure ou à une griffure par un chat
2D Resistivity Tomography Survey for Leachate Plume from Isundunrin Poultry Disposal Pits
Authors: Alani Fakunle Mutiu , Olalekan Alabi Olusegun , Ismaila Olatona Gbadebo , Felix Oladejo Oubusayo , Toyin Adeleke Joshua
Published: August 2021

Management of dead birds in poultry farms has been a major problem in Nigeria. This study aimed at using 2D resistivity tomography to outline leachate plume from disposal pits in a poultry farm. 2D electrical resistivity tomography were conducted along three profiles, two of which were 3.0 m and 25.0 m respectively to the two available mortality pits (Pit1 and Pit 2) while the third was 300.0 m away from the mortality Pit 1. Profile length of 100.0 m each and interspaced 5.0 m oriented in the North-East (Profile 1), South-East (Profile 2) and North-East (Profile 3) directions respectively was covered. 2D resistivity data inversions were performed on the obtained converted apparent resistivity using DIPROWIN software. Five water samples collected from five different hand dug wells available within the poultry farm were analysed for hydro chemical parameters. 2D results showed conductive paths occurrence in transverse one at the depth of 5.0 m, a horizontal distance of 45.0 m to 55.0 m, and had migrated down to the depth of 10.0 m. The second traverse showed varying resistivity values ranged 7.0 Î© m to 31.0 Î© m up to a depth of 15.0 m, an indication of the presence of clay soil. Low resistivity values ranged 14.0 Î© m to 49.0 Î© m were recorded in traverse 3. The extent of the contaminant is prominent at the topmost part of the soil and to almost 10.0 m depth. This was attributable to the contaminant from the deposit site of faeces of the poultry. Hydro chemical analysis indicated high values of Conductivity and Total Dissolved Solids (TDS). This confirms the migration of leachate from the disposal pits to the surrounding soils and groundwater and the 2D results obtained from disposal Pit 1. Other alternative methods of disposing dead birds are hereby recommended.
Differentiated Instruction in Education
Authors: Dr. D. Sumathi Desinguraj  , Mrs. J. Shyla Gnanam Ebenezer
Published: August 2021

Differentiated instruction is a way of planning and giving learning experiences according to the individual differences of the learners. Learners differ in their prior educational experiences, knowledge, interests, learning styles, personal experiences, readiness levels, motivation levels, and in their aptitudes. Traditional teaching methods do not address the student diversity in the classroom. So educators differentiate instructions in such a way that students of different grade levels grasp the concepts and exhibit mastery in the learned concepts.  Students are provided with multiple opportunities and options for taking in and making sense of the information they receive. In this article some of the advantages or merits of differentiated instructions are discussed.
COVID -19 and its effect on Marketing of Solar Water Heater
Authors: V. Vardhini  , Dr. P. Raja
Published: August 2021

Science, Technology, Inventions, innovations – these are some words which defines the progress and the development of human race. Energy sources like oil, coal and natural gas which humans are using for past many decades are economically feasible but their direct and indirect environmental consequences cannot be unseen. A new thing has emerged 2019 – 20 that we are not able to understand and not able to find the 100% cure is COVID -19. The whole world is in lockdown mode for last one year. Even though the activities have started post lockdown period, the installation and maintenance activities are not back to the track mainly because of the high dependency on exports from China for solar cells and solar modules. The ban on export activities have impacted the world. Researchers are predicting that SARS-CoV-2 can spread by water and aerosols also after taking reference from Amoy Garden case during SARS-CoV in 2003 and some of them have found the water samples positive for COVID-19 tests. As it is evident from the literature that some viruses are susceptible to high temperature, the same behavior was observed for corona virus so the Integrated Collector Storage (ICS) present in solar water heater system can be used for water heating. It is significant that by increasing the water temperature could reduce the disinfection time.
On Security, Minorities, and Opportunistic Narcissism
Authors: Pipyrou Stavroula
Published: August 2021

At a global level, the last two decades have consistently witnessed the encroachment of right-wing rhetoric and anti-minority logos, with several states clearly promoting a discourse of fear of minorities. Seeing minorities either as the ‘enemy within’ or a political necessity that must be endured, states are sceptical in how they recognise or incorporate minority identities that threaten ideologies of national homogeneity. Adopting an anthropological perspective and having engaged in long-term research on minorities in Greece and Italy, I argue that the state selectively recognises minority traits that are deemed ‘secure’ enough to be incorporated into the national body of policies and governance in what I term opportunistic narcissism; the process of highlighting minority differences, territorialising them, and finally claiming them for the national corpus.
MÚSICA COMO INSTRUMENTO NA APRENDIZAGEM
Authors: VELHO COTRIM FERNANDES SIMONE
Published: August 2021

A escola tem como objetivo entender como o aluno aprende, por isso destaca uma aprendizagem significativa, ou seja, que tenha significado para o aprendiz, que suas vivências sejam levadas em consideração para eficácia de um novo conhecimento. Nesse sentido, a aprendizagem musical tem muito a contribuir com o desenvolvimento do sujeito, trazendo benefícios cognitivos, motores e afetivos, proporcionando melhora, por exemplo, em características como atenção, disciplina, criatividade e motricidade fina. O intuito dessa pesquisa é apresentar ao leitor os caminhos do desenvolvimento e aprendizagem da criança na educação básica e a influência da música nesse caminho, além de levar a reflexão sobre novas possibilidades para o atual cenário da educação no Brasil.
O PAPEL DA ÉTICA NA DOCÊNCIA
Authors: OLIVEIRA DA SILVA TATIANA
Published: August 2021

A educação tem o propósito de proporcionar um ensino de qualidade, mas para tanto, é necessário investir na formação do professor. O professor deve ter conhecimento sobre responsabilidade, liberdade, moralidade, bondade, afeto, compromisso e colocar isso em prática nas suas relações éticas no desenvolvimento do caráter do aluno, pois a escola forma, além de um profissional, um ser humano, que vive em sociedade. Neste sentido, o objetivo aqui é fazer uma análise da importância da Ética na docência. A ética na docência se coloca como um princípio norteador que promove a transformação de comportamentos e desenvolve a habilidade do professor em refletir sobre a sua função, a fim de que a sua atuação seja mais eficaz na escola e na sociedade. Assim, conclui-se que a ética é extremamente importante na formação do professor. A construção de um país começa na educação. Por isso, é de extrema importância que esta educação fique a cargo de quem consegue transmitir aos futuros cidadãos comportamentos eticamente aceitos, dentro e fora da sala de aula. Para que isso aconteça, precisamos de professores competentes e conscientes que a sua missão não é apenas dotar o aluno de conhecimentos científicos, mas também de ensiná-los a serem seres sociais, que mais tarde assumirão o comando da sociedade.
A DEFICIÊNCIA INTELECTUAL E O SEU DESENVOLVIMENTO NO ENSINO INTEGRAL
Authors: INGRID MARQUES CUSTÓDIO DE OLIVEIRA TATIANE
Published: August 2021

Este artigo tem como objetivo trazer o tema deficiência intelectual e a sua inclusão de pessoas com alguma deficiência acontece, pelo prisma da educação transformadora e inclusiva, quando a qualidade acadêmica proposta poderá derrubar certas barreiras tradicionais que presenciamos dentro das escolas brasileiras. Para que isto aconteça, os educadores necessitam de contribuir para que o aluno com deficiência possa ter garantido o seu direito à educação e assim se integrar socialmente. Ressaltando que a população, de modo geral, precisa ter a consciência e o respeito, pois o mesmo é parte integrante de nossa sociedade, sendo capaz de se relacionar com outras pessoas, tendo a capacidade de realizar atividades que estejam ao seu alcance. Podendo assim frequentar uma escola como qualquer outra criança.
A PRÁTICA DA GESTÃO DEMOCRÁTICA NAS ESCOLAS
Authors: LIZI VIVIANE
Published: August 2021

O presente artigo traz uma discussão a respeito da atual situação da gestão escolar no ensino público brasileiro e seus desafios quanto a uma gestão democratizada que influi diretamente na construção de um espaço escolar mais eficaz e participativo a fim inovar transformando o ambiente educacional em tempo de redefinição do papel do Estado que necessita de mudanças e aprimoramento para enfrentar os novos desafios que cercam a educação nos dias atuais. A escola tem seu papel fundamentado dentro da sociedade e sua participação ativa que influencia diretamente o futuro de uma nação, portanto, o tema que será abordado neste artigo muito tem haver com a atual situação do país, em que os conflitos de ideias e ideais se fundem, a necessidade de participação ativa da sociedade nas tomadas de decisões que direta ou indiretamente se relacionam com a construção de uma sociedade civil mais democrática nas quais todos tem consciência da importância de decidir coletivamente o que é melhor para todos.
ECONOMIA URBANA E FINANÇAS: UMA ABORDAGEM SOBRE SÃO MIGUEL PAULISTA
Authors: ANDRADE DA SILVA MARIA FERNANDA
Published: August 2021

Nossa preocupação neste artigo é buscar compreender as relações socioeconômicas que se estabelecem no espaço urbano no bairro de São Miguel Paulista, o que envolve bancos e agentes financeiros. Esta análise inclui as formas de atuação que perpassam entre circuitos, o superior e o inferior, da economia urbana. A presença de ambos manifesta formas de materialidades distintas, tornando-as visíveis no espaço urbano. Os agentes hegemônicos do circuito superior detêm tecnologia moderna no campo da informação, da produção e contam com um volume maior capital. Essas variáveis permitem ao circuito superior o controle da economia, levando o circuito inferior a manter-se de forma subordinada. Entretanto, esses nexos complementam-se, relacionam-se e dividem o mesmo espaço da economia urbana.
Figuras pós-humanas e inteligência artificial: uma reflexão a partir de Black Mirror
Authors: Silva Bruna Coutinho , Veliq Fabiano
Published: August 2021

O presente trabalho tem como objetivo discutir sobre as figuras pós-humanas que emergem no cenário atual da realidade social e da ficção científica. Para tanto, iniciamos apresentando o declínio do projeto humanista da modernidade, para, desse modo, estabelecer o contexto da emergência do pós-humanismo. Posteriormente, tratamos da conceituação sobre tais figuras pós-humanas, especificamente, os androides e os ciborgues, seguida da explanação sobre a Inteligência Artificial (IA). Após a discussão teórica, e em conexão com a mesma, empreendemos a análise do episódio “Be right back”, de Black Mirror. A relevância da temática nos tempos atuais reside em as reflexões científicas acompanharem as produções tecnológicas que vêm colocando em questão o entendimento sobre o que é ou não humano e “borrando” cada vez mais essas fronteiras.
Sobre vírus, bactérias e animais: o bestiário simbólico de filmes sobre pandemias
Authors: Fantinel Danilo
Published: August 2021

A pandemia de COVID-19 reativou medos ancestrais decorrentes de doenças e da morte. Porém, elaboramos conteúdos do imaginário que atenuam essas angústias. Esses elementos imaginados instigam formas de pensar e de agir, estimulando também obras culturais, artísticas e midiáticas. Neste artigo, estudamos dez filmes para evidenciar o bestiário inspirador de títulos sobre surtos, epidemias e pandemias. Observamos também a imagem simbólica do inimigo invisível ligada a agentes patogênicos infecciosos e mortíferos. Para isso, recorremos aos Estudos do Imaginário, sobretudo a noções oferecidas por Gilbert Durand.
Konsep Kampus Merdeka Belajar di Era Revolusi Industri 4.0
Authors: Siregar Nurhayani , Sahirah Rafidatun , Harahap Arsikal Amsal
Published: August 2021

Lately, there has been a lot of discussion in the world of education, with the concept of freedom of learning being coined by the minister of education and culture, Nadiem Makarim. in terms of including the concept of a free campus of learning. the concept becomes an effort in dealing with the changing times. then how is the concept of an independent campus learning in the face of the industrial revolution era 4.0. and how the concept of an independent campus that had been sparked by the Minister of Education and Culture namely Mr. Nadiem Makarim as well as what is the problem of students at this time so that it requires a change in the concept of higher education for the better. considering that in this case, the era of the industrial revolution 4.0 is an era in which technology is increasingly high, so that in this case students from each tertiary institution are expected to be ready to face challenges in the industrial revolution era 4.0, with the concept of an independent campus they are directed to be more ready to work , working together, creative and can be useful for themselves and other communities.
Peran Kepemimpinan Kepala Madrasah dalam Meningkatkan Budaya Disiplin Siswa di MAS Patra Mandiri Plaju Palembang
Authors: Surya Sandy , Zainuri Ahmad , Habiburrahman Sayid
Published: August 2021

Discipline culture is a reflection of the quality of educational institutions. The low level of discipline is the main problem of every educational institution. The role of leadership is very much needed in overcoming this problem. This paper aims to describe the leadership role of madrasah principals in improving the disciplinary culture of students at MAS Patra Mandiri Plaju Palembang. This research uses a qualitative approach with a descriptive analytic study method. Data were collected using interview techniques, observation and documentation study. The results of this study indicate that the headmaster of MAS Patra Mandiri Plaju Palembang has played its role and function in improving the disciplinary culture of students in a fairly good category. This is supported by 2 factors, namely (1) the role models of madrasah principals in complying with school regulations; and (2) socialization of school discipline rules and sanctions for violations. The obstacles faced by madrasah principals are (1) there are still some teachers who do not exemplify student attitudes; and (2) there are still students who are not "deterred" to be given disciplinary violations.
Pesantren dan Pengembangan Studi Islam Berwawasa Gender
Authors: Fauzi Rahmat , Zebua Ali Marzuki
Published: August 2021

This article discusses efforts and strategies for developing Islamic studies in Islamic boarding schools that have gender insight. Previous studies on gender and Islamic boarding schools focused more on the socio-cultural dimensions of gender, power relations, women's empowerment, the image of women in the yellow book, figures and agencies. However, there are several studies that have tried to examine efforts to develop gender-based pesantren education at the formal institutional level. Very few have analyzed efforts to develop gender-based Islamic studies in the world of pesantren. This is more due to the difficulty in accepting some pesantren caregivers of the concept of gender equality, which according to them does not come from an Islamic scientific body. Using the integration-interconnection approach developed by Amin Abdullah and Jasser Auda, this paper explains that the development of Islamic studies in pesantren is urgently carried out by utilizing relevant concepts from other sciences such as cultural, social, economic, psychological and so on. Through the so-called scientific interconnections, new Islamic gender insights can be developed and understood more holistically and contextually in the academic environment of the pesantren.
Data analysis reveals that extreme events have increased the flood inundations in the Taquari River´s Valley, southern Brazil
Authors: Tognoli Francisco Manoel Wohnrath , Bruski Sabrina Deconti , Araujo Thiago Peixoto de
Published: August 2021

Flood inundations represent more than 62% of the deaths caused by natural disasters in Brazil. The dataset comprises the records of the Encantado´s pluviometric station, a municipality located beside the margin of the Taquari River in southern Brazil, which comprises the rainfall time series (n = 36,466) over 78 years, from April 1943 to December 2020. Complementary datasets also include the annual volume of precipitation per year and the level reached by the Taquari River during 44 flood inundations since 1941. The number of events is subsampled because only 32 years have the complete record of the river level. Three of the five major flood inundations at Encantado occurred after 2001, and the more severe flood recorded the maximum level of the Taquari River (20,27 meters) on July 8th, 2020. Thirty-four percent of all flood inundations in the city were recorded between 2011 and 2020. The months of July to October record 70% of all the events, but there is no record of floods in February and December throughout the data series. The human occupation of the floodplain has been fast in the last decades, and most of the urban area has a potential risk of being affected by flood inundations. Moreover, extreme rainfall events and flood events have been more frequent in the last 30 years. This database can contribute as a starting point for developing predictive models and verifying a possible correlation of floods with extreme events and global climatic changes.
CALCITE U-Pb DATING UNRAVELS THE AGE AND HYDROTHERMAL HISTORY OF THE GIANT SHUIYINDONG CARLIN-TYPE GOLD DEPOSIT IN THE GOLDEN TRIANGLE, SOUTH CHINA
Authors: Jin Xiao-Ye , Zhao Jian-Xin , Feng Yue-Xing , Hofstra Albert H. , Deng Xiao-Dong , Zhao Xin-Fu , Li Jian-Wei
Published: August 2021

The ages of Carlin-type gold deposits in the Golden Triangle of South China have long been questioned due to the general lack of minerals unequivocally linked to gold deposition that can be precisely dated using conventional radiogenic isotope techniques. Recent advances in U-Pb methods show that calcite can be used to constrain the ages of hydrothermal processes, but few studies have been applied to ore deposits. Herein, we show that this approach can be used to constrain the timing of hydrothermal activity that generated and overprinted the giant Shuiyindong Carlin-type gold deposit in the Golden Triangle. Three stages of calcite (Cal-1, Cal-2, and Cal-3) have been recognized in this deposit based on crosscutting relationships, cathodoluminescence colors, and chemical (U, Pb, and rare earth element [REE]) and isotope (C, O, Sr) compositions. Cal-1 is texturally associated with ore-stage jasperoid and disseminated Au-bearing arsenian pyrite in hydrothermally altered carbonate rocks, which suggests it is synmineralization. Cal-2 fills open spaces and has a distinct orange cathodoluminescence, suggesting that it precipitated during a second fluid pulse. Cal-1 and Cal-2 have similar carbonate rock-buffered chemical and isotopic compositions. Cal-3 occurs in veins that often contain realgar and/or orpiment and are chemically (low U, Pb, and REE) and isotopically (higher δ13C, lower δ18O and Sri values) distinct from Cal-1 and Cal-2, suggesting that it formed from a third fluid. U-Pb isotope analyses, by laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) for U-rich Cal-1 and Cal-2 and by LA-multicollector (MC)-ICP-MS for U-poor Cal-3, yield well-defined age constraints of 204.3 to 202.6, 191.9, and 139.3 to 137.1 Ma for Cal-1, Cal-2, and Cal-3, respectively. These new ages suggest that the Shuiyindong gold deposit formed in the late Triassic and was overprinted by hydrothermal events in the early Jurassic and early Cretaceous. Given the association of Cal-3 with orpiment and realgar, and previous geochronologic studies of several other major gold deposits in the Golden Triangle, we infer that the latest stage of calcite may be associated with an early Cretaceous regional gold metallogenic event. Combined with existing isotopic ages in the region, these new ages lead us to propose that Carlin-type gold deposits in the Golden Triangle formed during two metallogenic episodes in extensional settings, associated with the late Triassic Indochina orogeny and early Cretaceous paleo-Pacific plate subduction. This study shows that the calcite U-Pb method can be used to constrain the timing of Carlin-type gold deposits and successive hydrothermal events.
Memprediksi Jumlah Siswa Baru Menggunakan Metode Backpropagation (STUDI KASUS: SMK HARAPAN BANGSA KUALA)
Authors: Jayanti Kris , Katen Lumbanbatu  , Suci Ramadani
Published: August 2021

Artificial Neural Network (ANN) and time series data can be used for forecasting methods well. Artificial Neural Network is a method whose working principle is adapted from a mathematical model in humans or biological nerves. Neural networks are characterized by; (1) the pattern of connections between neurons (called architecture), (2) determining the weight of the connection (called training or learning), and (3) the activation function. The research objective was to obtain the best artificial neural network architecture, comparing the two methods of Backpropogation Neural Networks with the Radial Base Function Artificial Neural Network (RBF) method. This research is a research using real data (true experimental). This research was conducted at SMK Harapan Bangsa Kuala, which was obtained from 2015 to 2019. The results showed that for one iteration using the backpropagation method the result was 0,378197657 with a squared error 0.143033468, then the results achieved were not in accordance with the target.
Folistatina, resistencia a la insulina y composición corporal en adultos colombianos
Authors: Toloza F. J.K. , Ricardo-Silgado M. L. , Mantilla-Rivas J. O. , Morales-Álvarez M. C. , Pérez-Matos M. C. , Pinzón-Cortés J. A. , Pérez-Mayorga M. , Mendivil C. O.
Published: August 2021

Introducción: La folistatina es una proteína capaz de neutralizar varias hormonas de la familia del TGF-?, tales como la activina, las proteínas morfogénicas del hueso y la miostatina. Al inactivar la activina y la folistatina reduce la secreción de FSH. La folistatina se produce además de en el ovario en muchos otros tejidos, por ello se sospecha que tiene otros efectos. En ratones, la deleción genética de la folistatina se acompaña de resistencia a la insulina (RI). Sin embargo, la asociación entre la folistatina plasmática y RI medida directamente no ha sido evaluada en humanos.Métodos: En 81 participantes entre 30 y 69 años (56% mujeres, 54% con sobrepeso, 13% con obesidad), determinamos antropometría, composición corporal, factores de riesgo cardiovascular y múltiples índices de RI: Área incremental bajo la curva de insulina, índice de sensibilidad a la insulina según Gutt, Homeostatic Model Assessment – Insulin Resistance (HOMA-IR) e insulinemia en ayuno. Un subgrupo de 21 participantes se sometió además a un clamp hiperinsulinémico-euglucémico. La folistatina y la miostatina se midieron en plasma de ayuno, empleando técnicas inmunométricas.Resultados: La concentración promedio de folistatina fue 2.517±830 pg/mL, sin diferencia entre sexos (p=0,55). La folistatina tuvo una tendencia a correlación positiva con el porcentaje de masa magra (r=0,19, p=0,088) y negativa con el porcentaje de grasa corporal (r= -0,19, p=0,097). La folistatina no se correlacionó con índices de RI derivados de la PTOG pero sí con la captación corporal de glucosa en el clamp (r=0,42, p=0,031). No se halló asociación entre las concentraciones de folistatina y miostatina plasmáticas.Conclusión: Los niveles de folistatina mostraron una tendencia hacia una correlación positiva con la masa muscular y negativa con adiposidad corporal. Esto concuerda con el efecto inhibitorio de la folistatina sobre la miostatina. Aunque la folistatina no correlacionó con índices indirectos de RI, sí lo hizo con la determinación directa de sensibilidad a la insulina en el clamp hiperinsulinémico-euglucémico.
Asociación entre el gen de caveolina 1 (cav1) y el riesgo cardiovascular en adultos
Authors: Mora García Gustavo , Ruiz Díaz María Stephany , Alario Bello Ángelo , Gómez Camargo Doris , Gómez Alegría Claudio
Published: August 2021

La caveolina 1 es una proteína estructural que interviene en diversos procesos metabólicos. En estudios de asociación genética, el gen que la codifica CAV1 (7q31.2) se ha asociado a resistencia a la insulina, hipertensión, hipertrigliceridemia y c-HDL bajo. Sin embargo, se desconoce si variantes en CAV1 se asocian a obesidad e incremento en el riesgo cardiovascular (RCV).

Objetivo: Analizar la posible asociación entre variantes en CAV1 con el RCV en población del caribe colombiano.Metodología: Se realizó un estudio de asociación genética con 595 adultos de Cartagena de Indias. Se hizo la genotipificación de los polimorfismos de nucleótido simple (SNPs): rs3779512, rs926198, rs10207569, rs11773845, rs7804372, rs1049337. El RCV fue definido mediante el puntaje derivado del estudio de Framingham. Para estimar la asociación entre las variables de estudio se realizó un análisis de varianza ajustado y fueron construidos árboles de regresión. Se aplicó el ajuste de Bonferroni para pruebas múltiples, donde fuera necesario.Resultados: La variante rs1049337 se encontró asociada con el incremento del RCV (p=0,0001). Los sujetos con el genotipo TT en este locus tuvieron un mayor puntaje de RCV, +4,1 IC95% [0,8-8,0] en comparación con CC (p=0,03) y +4,3 IC95% [0,3-8,4] con CT (p=0,03). El árbol mostró que en el grupo TT (rs1049337) presentaba un mayor puntaje si los sujetos además contaban con el genotipo TT para rs3779512.Conclusiones: Las variantes rs1049337 y rs3779512 se encuentran asociadas a incremento en el puntaje de RCV.
Sarcopenia, una patología nueva que impacta a la vejez
Authors: Gutiérrez Cortés William Arbey , Martínez Fernández Fhara Estefanía , Olaya Sanmiguel Laura Camila
Published: August 2021

La sarcopenia es un síndrome frecuente en los ancianos, caracterizado por una pérdida gradual, marcada y generalizada de masa muscular esquelética, relacionada con el envejecimiento, que se evidencia en la disminución de fuerza y agilidad, la cual puede generar discapacidad física que a su vez aumenta el grado de dependencia del paciente, disminuyendo así su calidad de vida y aumentando su mortalidad. El Grupo Europeo de Trabajo sobre la Sarcopenia en Personas de Edad Avanzada (EWGSOP, por sus iniciales en inglés) emplea para el diagnóstico de sarcopenia la presencia de los siguientes criterios: masa muscular disminuida y una función muscular deficiente que es determinada por la fuerza o rendimiento del paciente, este diagnóstico se confirma con los criterios que son: 1. Masa muscular baja, 2. Menor fuerza muscular, 3. Menor rendimiento físico. El manejo actual de la sarcopenia emplea un tratamiento no farmacológico que se centra en el cambio de los estilos de vida como son aumentar la actividad física y mejorar la nutrición y, en el tratamiento farmacológico que tiene como objetivo recuperar la funcionalidad, la movilidad y la masa muscular de los pacientes.
Misceláneos
Authors: Diabetes y Metabolismo Asociación Colombiana de Endocrinología
Published: August 2021

Listado

Presentación Oral Evaluación de la eficacia de dos inhibidores de la fosfodiesterasa 5 combinados con ginkgo biloba, en el manejo de la disfunción eréctil en una muestra de hombres con enfermedades crónicas.  Seudónimo: Negroncho

Presentación Oral  Características inmunohistoquímicas y sociodemográficas de pacientes con tumores neuroendocrinos en un hospital de tercer nivel, 2012-2017.  Seudónimo: CAED

Presentación Oral Beneficios del brócoli sobre la construcción muscular en deportistas que practican entrenamiento específico de hipertrofia (HST). Seudónimo: Nutrifit
Misceláneos
Authors: Diabetes y Metabolismo Asociación Colombiana de Endocrinología
Published: August 2021

Listado

Póster El Estado República de Colombia cuenta con precedente constitucional jurisprudencial T-622 de 2014, sentencia que reafirma la importancia del diagnóstico certero de los pacientes INTERSEXUALES y actualiza cómo mira el Estado a estos pacientes.  S. Chahin, F. Mejía

Póster Caso emblemático “XXXX” estado intersexual demanda efectiva prevalencia “regla jurisprudencial constitucional pro infancia” por ausencia de asertivo reconocimiento gonadal civil, “REGOCI”. S. Chahin, F. Mejia.

Póster Utilidad de la plasmaféresis en pancreatitis aguda por hipertrigliceridemia: a propósito de un caso.  Concha Mejía Alejandro, Montaño Padilla Gina Sofía, Rincón Reinaldo, Rodríguez Ruiz Karen

Póster Correlation between androgen receptor / estrogen receptor ratio and A 5-Genes proliferation signature in estrogen receptorpositive breast cancer patients.  Rangel N, Rondon-Lagos M, Annaratone L, Cassoni P, Sapino A, Castellano I.

Póster Hipogonadismo obesogénico y respuesta a la terapia de remplazo hormonal: presentación de una serie de casos.  Palacio JI, Jaramillo A, Rosero RJ.

Póster Terapia con lutecio en pacientes con tumores neuroendocrinos bien diferenciados en progresión. Clínica las américas 2012-2018, Medellín, Colombia. Reporte de casos.  Vásquez M., Aristizábal N., Torres JL., Quintero FM.

Póster Cirugía mínimamente invasiva video-asistida para corazón carcinoide.  Velásquez-Uribe OA, Muñoz E, Morales S, Gandara J, Román-González A .

Póster Histopatología testicular de ratas BIOU: Wistar expuestas a malatión.  Serrano RA, Hernández GA, Hung S, Lozano R, Paoli M, Gómez Pérez R.

Póster Posible efecto de la altitud en la aparición de paragangliomas.  Oscar Arcos, Viviana Fuentes, María Fernanda Zambrano, Jackeline Munier, Alex Valenzuela, Miguel Omehara, Fernando Lizcano.

Póster Infecciones asociadas a la atención en salud en pacientes endocrinológicos en unidades de cuidados intensivos, Cartagena de Indias, Colombia. Ochoa Díaz MM, Gómez Camargo D.
Endocrinología Pediátrica
Authors: Diabetes y Metabolismo Asociación Colombiana de Endocrinología
Published: August 2021

Listado:

Disforias de género impuestas u obligadas: crónica (fábula y moraleja): entre la salud mental y el funcionamiento orgánico biogenético.   Silvia Cristina Chahín Ferreyra

Transición en la diabetes mellitus tipo 1 (DM1).    Juan José Ramírez Jiménez

Hiperplasia congénita de suprarrenales.    Mauricio Coll Barrios

Manejo del paciente con Klinefelter y Turner.    Martín Toro R.
Hipófisis y Suprarrenales
Authors: Diabetes y Metabolismo Asociación Colombiana de Endocrinología
Published: August 2021

Listado:

Elección de la primera línea de tratamiento en tumores neuroendócrinos (TNE) enteropancreáticos de bajo grado en estado avanzado.   Gloria Garavito

Enfoque terapéutico de adenomas no funcionantes (ANF).    Karina Danilowicz

Hiperaldosteronismo primario.    Carlos Alfonso Builes Barrera

Hipopituitarismo: causas y suplencia.    Alejandro Pinzón Tovar

Insuficiencia adrenal primaria (IAP), diagnóstico y tratamiento.    Doly Nubia Pantoja Guerrero

Metas en el manejo del paciente con acromegalia.    Karina Danilowicz
Orbitopatía tiroidea: protocolo de manejo basado en revisión de la evidencia
Authors: Gómez C. , Imitola A. , Taboada L. B. , Henao D. C. , Marín L. F. , Camargo J. , Kattath L. , Fonseca C. , Colón C. , Ascnher P.
Published: August 2021

La orbitopatía tiroidea es una patología potencialmente grave que amenaza la visión. Es la manifestación extratiroidea más frecuente de la enfermedad de Graves y, aunque la prevalencia no está evaluada en Colombia, puede producir pérdida de la visión, con consecuencias catastróficas. Teniendo en cuenta lo anterior, se realizó este trabajo con el objetivo de describir su enfoque diagnóstico y terapéutico basado en la mejor evidencia disponible. Se elaboró un protocolo de manejo aplicable a nuestro medio y se realizó una evaluación y adaptación de la guía European Group on Graves’ Orbitopathy (EUGOGO) del 2016 (1). Para la evaluación se usó la herramienta AGREE IIy se utilizó la metodología GRADE para la graduación de la calidad de la evidencia y formulación de las recomendaciones (2). Adicionalmente, se hizo una revisión sistemática de la literatura con el objetivo de evaluar la eficacia de la terapia biológica en el manejo de la orbitopatía de Graves. Se presentan las recomendaciones para el diagnóstico, tratamiento y seguimiento. Se recalca la importancia de contar con un equipo multidisciplinario con experiencia en el manejo de la orbitopatía tiroidea (endocrinología, oftalmología, cirugía de órbita, radioterapia y reumatología), idealmente en un centro de tercer nivel de atención. Es esencial la clasificación adecuada para determinar qué pacientes se benefician del tratamiento inmunosupresor. Si se maneja de forma oportuna, se puede lograr una disminución de la aparición de secuelas irreversibles
Hipoglucemia en pacientes con diabetes mellitus en los servicios de urgencias de dos hospitales de Bogotá, 2015-2017
Authors: Chaves W. , Martínez L. , Díaz D. , Hernández D. , Sanabria M.
Published: August 2021

Introducción: desde el punto de vista geno y fenotípico, la población diabética es heterogénea, lo que hace que algunos grupos especiales sean más susceptibles a complicaciones durante el tratamiento. Dentro de estas complicaciones, la hipoglucemia, es un motivo frecuente de consulta; sin embargo, la información acerca de episodios de esta alteración es limitada. Objetivo: determinar las características sociodemográficas y clínicas de los pacientes diabéticos con hipoglucemia en los servicios de urgencias del Hospital de San José y el Hospital Infantil Universitario de San José. Metodología: evaluación a una cohorte retrospectiva de pacientes diabéticos con hipoglucemia en los servicios de urgencias, durante enero de 2015 a diciembre de 2017. Se hizo un análisis descriptivo de los factores demográficos, clínicos y terapéuticos de esta población. Los datos fueron recolectados de las historias clínicas y las características fueron analizadas mediante estadística descriptiva. Resultados: dentro de los datos encontrados, 201 pacientes presentaron hipoglucemia al ingreso (12,5 %). Con una mediana de 70 años, el 85,5 % eran diabéticos tipo 2; de estos, 99 % tenían manejo con insulina; con mayor frecuencia usaron insulina glargina (58,1 %) e insulina glulisina (36,3 %). El 36,6 % usó medicamentos orales, principalmente biguanidas; y la combinación más frecuente fue insulina basal más insulina de corta acción, en el 56,7 %. La mediana de glucosa fue de 40,5 mg/dL y la prueba de hemoglobina glicosilada (HbA1c) fue de 6,7 %. La mortalidad hallada en esta población fue del 7,5 %. Conclusiones: la prevalencia de hipoglucemia en este estudio fue baja. Los resultados podrían sugerir la falta de individualización al momento de escoger los tratamientos y los objetivos terapéuticos, lo que refleja un aumento de los episodios de hipoglucemia grave. Por lo tanto, se debe realizar un tratamiento centrado en el paciente, considerando la presencia de episodios previos, los antecedentes de enfermedad cardiovascular, las enfermedades concomitantes asociadas, el peso, el costo de los medicamentos y la edad.
Quemerina, omentina-1 y miR-103p y su relación con la diabetes mellitus gestacional
Authors: Sosa García B. C. , Mendieta Zerón H. , Hinojosa Suárez A. C. , García M. C.
Published: August 2021

Diversos genes pueden desencadenar la diabetes mellitus gestacional (DMG), considerada como un problema de salud pública de etiología compleja y multifactorial. Objetivo: presentar una revisión de tema de la evidencia científica disponible sobre el impacto de la expresión de los genes omentina-1, quemerina y miR-1013p, implicados en el desarrollo de la DMG. Materiales y métodos: se realizó una búsqueda de estudios electrónicos transversales a través de la base de datos registrados en MEDLINE y PUBMED, publicados durante 2010-2019, que valoraran mediciones de los tres genes en mujeres con DMG. Resultados: ocho artículos cumplieron con los criterios de inclusión, cuatro artículos midieron los niveles de quemerina, tres de omentina-1 y uno de miR-103p. Entre los niveles de quemerina se mostró que la circulación de quemerina y miR103p se correlacionó positivamente con las variables metabólicas durante el primer y tercer trimestre del embarazo. Se demostró que la liberación de omentina-1 fue mayor en el tejido adiposo vs. placenta cuando se presenta obesidad. Conclusión: la expresión de genes y la presencia de obesidad están relacionados con el desarrollo de la diabetes mellitus gestacional.
Manejo exitoso de macroadenoma hipofisario no funcionante con cabergolina
Authors: Sarmiento J. G. , Pérez Urrea L. V. , López Pinzón ¨P. A. , Galván Salas W. L.
Published: August 2021

Los adenomas hipofisarios no funcionantes (AHNF) son aquellos que no se acompañan de ninguna manifestación de hipersecreción hormonal. Sus síntomas se deben al efecto compresivo por crecimiento tumoral, y la cirugía transesfenoidal es el tratamiento de elección como terapia inicial, mientras que en aquellos en los cuales no se presente sintomatología se sugiere el manejo expectante. No existe en el momento un tratamiento farmacológico estandarizado para el manejo de los AHNF. Sin embargo, se ha postulado el uso de agonistas dopaminérgicos en la reducción del tamaño de los AHNF. Se presenta el caso de una paciente con un hallazgo incidental de AHNF en contacto con el quiasma óptico, sin manifestaciones clínicas, quien rechazó la intervención quirúrgica, por lo cual se realizó una prueba terapéutica con cabergolina. Después de 6 meses de tratamiento, se realizó una resonancia magnética en la que se evidenció la reducción del volumen tumoral del 73 % sin contacto con el quiasma