bluuebunny/crossref_metadata_2025 huggingface dataset:
Influence of altitude on matching characteristic of electronic-controlled pneumatic two-stage turbocharging system with diesel engine
Authors: Liu Ruilin , Zhang Zhongjie , Yang Chunhao , Jiao Yufei , Zhou Guangmeng , Ma Jiaming
Published: January 2020

Two-stage turbocharging technology is a solution to reduce turbo lag and improve the performance of engine and matching characteristics at high altitudes. In the present study, an engine testing system was established to study combustion performance and matching characteristics of a regulated two-stage turbocharging system (R2S) at different simulated altitudes. An equivalent turbocharger concept was put forward aiming to simplify the R2S with three bypass valves, and the total equivalent turbine flow area and equivalent efficiency of the R2S were obtained based on a theoretical study. Intake characteristics, combustion process, torque, power and fuel economy of the diesel engine matched with R2S were analyzed at different altitudes. The results showed that compared with 0 m, intake pressure, maximum combustion pressure, cumulative heat release, heat release rate decreased by 36.5%, 33.6%, 33.5%, 21.6%, −8.9% at 4000 r/min, and decreased by 12.3%, 2.9%, 16.4%, 8.8%, −5.4% at the speed of 2000 r/min at the altitude of 5000 m. The torque, fuel consumption and fuel consumption rate decreased by 10.1%, 5.1% and 5.4% at engine speed of 2000 r/min and by 35.7%, 27.6% and 8.9% at engine speed of 4000 r/min at 5000 m.
Determination of the viability of retinispora (Hinoki cypress) seeds using shortwave infrared hyperspectral imaging spectroscopy
Authors: Mukasa Perez , Wakholi Collins , Mohammad Akbar Faqeerzada , Park Eunsoo , Lee Jayoung , Suh Hyun Kwon , Mo Changyeun , Lee Hoonsoo , Baek Insuck , Kim Moon S , Cho Byoung-Kwan
Published: January 2020

The combination of hyperspectral imaging with multivariate data analysis methods has recently been applied to develop a nondestructive technique, required to determine the seed viability of artificially aged vegetable and cereal seeds. In this study, the potential of shortwave infrared hyperspectral imaging to determine the viability of naturally aged seeds was investigated and thereafter a model for online seed sorting system was developed. The hyperspectral images of 400 Hinoki cypress tree seeds were acquired, and germination tests were conducted for viability confirmation, which indicated 31.5% of the viable seeds. Partial least square discriminant analysis models with 179 variables in the wavelength region of 1000–1800 nm were developed with a maximum model accuracy of 98.4% and 93.8% in both the calibration and validation sets, respectively. The partial least square discriminant analysis beta coefficient revealed the key wavelengths to differentiate viable from nonviable seeds, determined based on the differences in the chemical compositions of the seeds, including their lipid and fatty acid contents, which may control the germination ability of the seeds. The most effective wavelengths were selected using two model-based variable selection methods (i.e., the variable importance of projection (15 variables) and the successive projections algorithm (8 variables)) to develop the model. The successive projections algorithm wavelength selection method was considered to develop a viability model, and its application to the raw data resulted in a prediction accuracy of 94.7% in the calibration set and 92.2% in the validation set. These results demonstrate the potential of shortwave infrared hyperspectral imaging spectroscopy as a powerful nondestructive method to determine the viability of Hinoki cypress seeds. This method could be applied to develop an online seed sorting system for seed companies and nurseries.
Transitional justice for women: Acknowledge the past, fix the present, prevent repetitions in the future
Authors: Bello y Villarino José-Miguel
Published: January 2020

Ramona Vijeyarasa recently published in this journal an article advocating for the law in general, and legislation in particular, to be gender responsive. She argued that to redress gender inequality, the law must address the different needs and position of women. Here I propose a bigger scope for the intervention needed to redress legally-originated gender inequality. I contend that a system of transitional justice for women is necessary. This intervention, based on the equity principle of fairness and a need to repair a damage caused by the law, is proposed as a temporary measure until adequate redress is provided.
When Can Families Fill Voids? Firms’ Reliance on Formal and Informal Institutions in R&D Decisions
Authors: Brinkerink Jasper , Rondi Emanuela
Published: January 2020

Firms are more prone to allocate their resources to research and development (R&D) when they are confident about their ability to appropriate the value created through these activities. In this regard, policymakers introduce formal intellectual property rights (IPR) institutions to create an innovation-friendly environment. Less formalized shared values and norms are however likely to affect the extent to which organizations depend on the strength of formal institutions in determining their R&D strategy. Embracing an institution-based perspective on firm-level strategic decision-making, we examine whether the degree to which a firm relies on strong formal IPR institutions in R&D decisions depends on the configuration of informal institutions in its environment, including family and societal culture. We test our hypotheses on a representative sample of privately-held European manufacturing firms and find that the family institution can play an “institutional void filling” role through involvement in ownership and management. This is particularly the case when the firm is embedded in a collectivist culture coherent with the family’s values and norms imbued in the business. Our study offers contributions to the institution-based view, innovation, and family business literatures.
Equity Crowdfunding: High-Quality or Low-Quality Entrepreneurs?
Authors: Blaseg Daniel , Cumming Douglas , Koetter Michael
Published: January 2020

Equity crowdfunding (ECF) has potential benefits that might be attractive to high-quality entrepreneurs, including fast access to a large pool of investors and obtaining feedback from the market. However, there are potential costs associated with ECF due to early public disclosure of entrepreneurial activities, communication costs with large pools of investors, and equity dilution that could discourage future equity investors; these costs suggest that ECF attracts low-quality entrepreneurs. In this paper, we hypothesize that entrepreneurs tied to more risky banks are more likely to be low-quality entrepreneurs and thus are more likely to use ECF. A large sample of ECF campaigns in Germany shows strong evidence that connections to distressed banks push entrepreneurs to use ECF. We find some evidence, albeit less robust, that entrepreneurs who can access other forms of equity are less likely to use ECF. Finally, the data indicate that entrepreneurs who access ECF are more likely to fail.
A Person-Centered Perspective on the Combined Effects of Global and Specific Levels of Job Engagement
Authors: Gillet Nicolas , Morin Alexandre J. S. , Jeoffrion Christine , Fouquereau Evelyne
Published: January 2020

This study examines how the different dimensions of job engagement combine within different profiles of workers ( n = 264). This research also documents the relations between the identified job engagement profiles, demographic characteristics (gender, age, education, working time, and organizational tenure), job characteristics (work autonomy, task variety, task significance, task identity, and feedback), attitudes (affective and normative commitment), and psychological health (emotional exhaustion and ill-being). Latent profile analysis revealed four profiles of employees defined based on their global and specific (physical, emotional, and cognitive) job engagement levels: Globally Disengaged, Globally Engaged, Globally but not Emotionally Engaged, and Moderately Engaged. Employees’ perceptions of task variety and feedback shared statistically significant relations with their likelihood of membership into all latent profiles. Profiles were finally showed to be meaningfully related to employees’ levels of affective commitment, normative commitment, emotional exhaustion, and ill-being.
Discontinuous to continuous therapy for persistent diabetic macular edema leads to reduction in treatment frequency
Authors: Adams Olufemi E , Schechet Sidney A , Hariprasad Seenu M
Published: January 2020

Objective:

To evaluate, in the setting of persistent diabetic macular edema, the impact that continuous fluocinolone acetonide delivery has on treatment burden, visual acuity, central retinal thickness, and intraocular pressure.

Materials and methods:

A single-center, retrospective, cohort study of patients with persistent diabetic macular edema, previously treated with anti–vascular endothelial growth factor injections, dexamethasone implants, or focal laser, who were subsequently treated with fluocinolone acetonide was conducted. All retinal visits were analyzed prior to fluocinolone acetonide, until the most recent follow-up visit. Primary outcomes were pre– and post–fluocinolone acetonide changes in the best-corrected visual acuity and number of treatments required for diabetic macular edema. Secondary outcomes included changes in the central retinal thickness and intraocular pressure.

Results:

A total of 19 eyes with persistent diabetic macular edema were included and followed for a mean (SD) of 399.3 (222.9) days. Post–fluocinolone acetonide, the mean best-corrected visual acuity improved by 0.4 ETDRS letters for all eyes ( p = 0.895) and the central retinal thickness decreased by 34.2 µm ( p = 0.077). After fluocinolone acetonide, the number of treatments decreased from an average of one treatment every 2.7 months to one every 6 months ( p = 0.009). Furthermore, post–fluocinolone acetonide, 10/19 eyes (52.6%) did not require additional treatment due to a dry macula, and those who did experienced a non-statistically significant reduction of treatments, from one every 2.6 months pre–fluocinolone acetonide, to one every 2.8 months post–fluocinolone acetonide ( p = 0.622).

Conclusions:

In the setting of persistent diabetic macular edema, fluocinolone acetonide significantly reduces the therapeutic burden, while maintaining best-corrected visual acuity and improving the central retinal thickness. In patient-centered discussions, judiciously employing fluocinolone acetonide should be performed to mitigate this therapeutic burden for patients.
Effects of topical antiglaucomatous medications on central corneal epithelial thickness by anterior segment optical coherence tomography
Authors: Doğan Emine , Çakır Burçin Köklü , Aksoy Nilgün Özkan , Celik Erkan , Erkorkmaz Ünal
Published: January 2020

Purpose:

To evaluate the effect of topical antiglaucomatous medications on central corneal epithelial thickness measured by anterior segment optical coherence tomography.

Materials and methods:

A total of 153 eyes of 153 patients using topical antiglaucomatous medications and 110 eyes of 110 control subjects were enrolled. Glaucoma type, duration of therapy, the number of drugs, and drops/day were noted in the patient group. Patients and control subjects underwent ocular examinations including Schirmer test, slit lamp examination for tear film break-up time, and anterior segment optical coherence tomography for central corneal thickness and central corneal epithelial thickness. Central corneal epithelial thickness and other data were evaluated separately with regard to glaucoma type, duration of therapy, the number of drops, and drugs in the patient group.

Results:

The mean ages of the patients and controls were 60.1 ± 10.8 and 58.7 ± 11.2 years, respectively. The groups were similar with regard to mean age and gender (p = 0.058, p = 0.734, respectively). The median (interquartile range) central corneal thickness was 536 (54) µm in patients and 552 (53) µm in controls (p = 0.011). The median (interquartile range) central corneal epithelial thickness of patients and controls were 56 (4) µm and 60 (8) µm, respectively (p < 0.001). The median (interquartile range) tear film break-up time and Schirmer were 12 (6) s and 10 (8) mm in patients and 16 (2) s and 18 (4) mm in controls, respectively (p < 0.001, p < 0.001). In patient group, there was no significant difference in the median central corneal thickness, central corneal epithelial thickness, and tear film break-up time in terms of glaucoma type, duration of therapy, the number of drugs, and the number of daily drops. Only the median Schirmer test was found to be statistically lower in terms of number of daily eye drops (p = 0.039).

Conclusion:

Using topical antiglaucomatous medications seems to affect the central corneal epithelial thickness in glaucoma patients. Central corneal epithelial thickness was thinner in glaucoma patients than controls. Anterior segment optical coherence tomography might be helpful to evaluate the effect of antiglaucomatous medications on central corneal epithelial thickness during treatment.
microRNA and exosome profiling in multiple sclerosis
Authors: Mycko Marcin P , Baranzini Sergio E
Published: January 2020

New DNA sequencing technologies have uncovered non-coding RNA (ncRNA) as a major player in regulating cellular processes and can no longer be dismissed as “junk” or “dark” RNA. Among the ncRNA, microRNA (miRNA) is arguably the most extensively characterized category and a number of studies have implicated them in regulating critical functions that can influence autoimmune demyelination. Of specific interest to multiple sclerosis (MS), miRNA have been implicated in both regulating immune responses and myelination, thus making them an attractive candidate for both pharmacological intervention and as disease biomarkers. In addition, exosomes, small vesicles secreted by most cell types and present in all body fluids, have been also shown to play roles in immune signaling, inflammation and angiogenesis. Therefore, exosomes are also being explored as tools for therapeutic delivery and as biomarkers. This article reviews the recent advances in miRNA and exosome profiling in MS and experimental models.
Race and ethnicity on MS presentation and disease course
Authors: Amezcua Lilyana , McCauley Jacob L
Published: January 2020

Multiple sclerosis (MS) has a strong racial and ethnic component and disproportionately affects whites of European background. Recent incidence reports suggest an increasing rate of MS among African Americans compared with whites. Despite this recent increase in MS in African Americans, Hispanics and Asians are significantly less likely to develop MS than whites of European ancestry. MS-specific mortality trends demonstrate distinctive disparities by race/ethnicity and age, suggesting that there is an unequal burden of disease. Inequalities in health along with differences in clinical characteristics that may be genetic, environmental, and social in origin may be contributing to disease variability and be suggestive of endophenotypes. The overarching goal of this review was to summarize the current understanding on the variability of disease that we observe in selected racial and ethnic populations: Hispanics and African Americans. Future challenges will be to unravel the genetic, environmental, and social determinants of the observed racial/ethnic disparities.
Lifestylisation of the social: The government of diabetes care in Denmark
Authors: Knudsen Sine Grønborg , Triantafillou Peter
Published: January 2020

Since the 1970s, the public authorities of many OECD countries have emphasised the need for preventing lifestyle diseases and promoting the vigour of their populations. Based on the Foucauldian analytics of dispositive, we critically address some of the normative implications of the preventive interventions in the area of type 2 diabetes care. Through an analysis of public health documents from 1981 to 2016, it is shown that the government of lifestyle was extended and institutionalised by a reform of the Danish public sector in 2007. Following the reform, rationalities of public health policies sought to prevent unhealthy lifestyles not only through individual behaviour but also through the social surroundings of citizens. In contrast to the claim that we are seeing a retraction of state responsibility and interventions in the area of public health, it is suggested that we are witnessing an expansion in state ambitions expressed through a lifestyle dispositive. These ambitions are less about transferring the responsibility to the individual and more about governing and mobilising the social relations and environments of type 2 diabetes patients and citizens in general to make the everyday choice of a healthy lifestyle easier.
Dealing With Randomness in Match Outcomes: How to Rethink Performance Evaluation in European Club Football Using Expected Goals
Authors: Brechot Marc , Flepp Raphael
Published: January 2020

In European club football, decision makers often rely on recent match outcomes when evaluating team performance, even though short-term results are heavily influenced by randomness. This can lead to systematic misjudgments. In this article, we propose a complementary approach for performance evaluation. We build upon the concept of expected goals based on quantified scoring chances and develop a chart that visualizes situations in which a team’s true performance likely deviates from the performance indicated by match outcomes. This should prevent clubs from making flawed decisions when match outcomes are misleading due to the influence of random forces.
Epilepsy Benchmarks Area I: Understanding the Causes of the Epilepsies and Epilepsy-Related Neurologic, Psychiatric, and Somatic Conditions
Authors: Chang Bernard S. , Krishnan Vaishnav , Dulla Chris G. , Jette Nathalie , Marsh Eric D. , Dacks Penny A. , Whittemore Vicky , Poduri Annapurna ,   for the NINDS/AES Epilepsy Research Benchmark Stewards Committee
Published: January 2020

The 2014 NINDS Benchmarks for Epilepsy Research included area I: Understand the causes of the epilepsies and epilepsy-related neurologic, psychiatric, and somatic conditions. In preparation for the 2020 Curing Epilepsies Conference, where the Benchmarks will be revised, this review will cover scientific progress toward that Benchmark, with emphasize on studies since 2016.
Vagus Nerve Stimulation Paired With Rehabilitative Training Enhances Motor Recovery After Bilateral Spinal Cord Injury to Cervical Forelimb Motor Pools
Authors: Darrow Michael J. , Torres Miranda , Sosa Maria J. , Danaphongse Tanya T. , Haider Zainab , Rennaker Robert L. , Kilgard Michael P. , Hays Seth A.
Published: January 2020

Closed-loop vagus nerve stimulation (VNS) paired with rehabilitative training has emerged as a strategy to enhance recovery after neurological injury. Previous studies demonstrate that brief bursts of closed-loop VNS paired with rehabilitative training substantially improve recovery of forelimb motor function in models of unilateral and bilateral contusive spinal cord injury (SCI) at spinal level C5/6. While these findings provide initial evidence of the utility of VNS for SCI, the injury model used in these studies spares the majority of alpha motor neurons originating in C7-T1 that innervate distal forelimb muscles. Because the clinical manifestation of SCI in many patients involves damage at these levels, it is important to define whether damage to the distal forelimb motor neuron pools limits VNS-dependent recovery. In this study, we assessed recovery of forelimb function in rats that received a bilateral incomplete contusive SCI at C7/8 and underwent extensive rehabilitative training with or without paired VNS. The study design, including planned sample size, assessments, and statistical comparisons, was preregistered prior to beginning data collection ( https://osf.io/ysvgf/ ). VNS paired with rehabilitative training significantly improved recovery of volitional forelimb strength compared to equivalent rehabilitative training without VNS. Additionally, VNS-dependent enhancement of recovery generalized to 2 similar, but untrained, forelimb tasks. These findings indicate that damage to alpha motor neurons does not prevent VNS-dependent enhancement of recovery and provides additional evidence to support the evaluation of closed-loop VNS paired with rehabilitation in patients with incomplete cervical SCI.
The Coexistence of Carpal Tunnel Syndrome in Workers With Trigger Digit
Authors: Fitch Michael S. , Thiese Matthew S. , Wood Eric M. , Kapellusch Jay M. , Hegmann Kurt T.
Published: January 2020

Background: The objective of this study was to investigate the prevalence of carpal tunnel syndrome (CTS) in workers with trigger digit. There are few cross-sectional studies that assess this relationship. Methods: A baseline examination of 1216 workers from 17 diverse manufacturing facilities was conducted. Worker demographics, medical history, and symptoms of trigger digit were assessed. Age, sex, and body mass index were obtained. Biomechanical factors were individually measured using the Strain Index (SI). Prevalence was assessed with univariate and multivariate logistic regression. Results: Unadjusted prevalence of trigger digit was 12.0%, and among those workers, there was an unadjusted CTS prevalence of 26.7%. The adjusted multivariate model found an odds ratio (OR) of CTS of 1.56 (95% confidence interval [CI], 1.03-2.36) among the workers with trigger digit. The ORs of CTS for SI (OR = 1.53 [95% CI, 1.04-2.23]), age (OR = 1.03 [95% CI, 1.01-1.04]), and current smoking (OR = 1.76 [95% CI, 1.12-2.75]) were also significant. Sex and diabetes were not statistically significant covariates. Conclusion: The prevalence of CTS is higher among workers with trigger digit.
Radical Resection of a Recurrent Giant Cell Tumor of the Distal Ulna and Immediate Reconstruction With a Distal Radio-Ulnar Joint Implant Arthroplasty
Authors: Jones Neil F. , Graham David J.
Published: January 2020

Background: Giant cell tumors (GCTs) of the distal ulna are rare. Despite being benign, they can be locally aggressive and may recur following conventional treatment by curettage and bone grafting. Salvage reconstructive options after failed conventional treatment include Darrach resection, Suave-Kapandji procedure, hemi-arthroplasty, or total joint arthroplasty. Methods: We discuss reconstruction options for the distal radio-ulnar joint following tumor resection, and present the outcomes of a constrained distal radio-ulnar prosthesis in a 29-year-old male following resection of a distal ulna GCT. Results: Reconstruction of the distal radio-ulnar joint by a constrained prothesis yielded excellent functional outcomes following resection of a GCT of the distal ulna. Conclusions: This case demonstrates that successful oncologic and functional outcomes can be achieved by radical resection of a recurrent GCT of the distal ulna and reconstruction with a constrained total joint arthroplasty.
Hand It to Dr Google: The Quality of Online Information on Ganglion Cysts
Authors: Ji Tianshu Angela , Wells Neil , Ingledew Paris-Ann
Published: January 2020

Background: The internet is becoming a common source of health information for hand surgery patients. This study evaluates the quality of web-based resources on ganglion cysts of the hand. Methods: We completed a search for “ganglion cyst” on 3 search engines (Google, Dogpile, and Yippy). The quality of the top-100 patient education websites was assessed using a validated internet rating tool. Websites were evaluated based on affiliation, accountability, currency, interactivity, website organization, readability, coverage, and accuracy. Results: Of the 100 websites, the majority (74%) had commercial affiliations. Only 34% of websites identified an author, and even fewer identified the authors’ credentials (27%) or affiliations (26%). A third of the websites cited references, and less than half provided an update date. The average readability based on Flesch-Kincaid grade level was 9.2, and only 3% could be read at or below 6th grade reading level. Prevention was the most poorly covered topic at 13% due to omission. In all, 66% of the websites were completely accurate in terms of global accuracy. Websites were most likely to present inaccurate information on treatment, often failing to mention conservative treatment (watch-and-wait approach) or promoting the use of natural health products. We also found 5% of websites presented closed rupture of the ganglion cyst as a legitimate home remedy. Conclusions: The overall quality of online information on ganglion cysts is highly variable and may occasionally be harmful for patients. It is increasingly important for physicians to prompt patients about their internet use.
The Cutaneous Branch of the Deep Palmar Artery and Blood Supply to the Proximal Hypothenar Skin: An Anatomic Research Oriented to Flap Design
Authors: Postan Daniel , Poitevin Luciano Augusto
Published: January 2020

Background: The distal half of the hypothenar eminence (HE) skin vascularization has been extensively investigated. Different flaps have been described based on these arteries. Similarly, the vascularization of the proximal half of HE has also been investigated, although to a lesser extent. The aim of this paper is to determine, in a cadaver sample, the anatomy of the hypothenar cutaneous branches in their proximal half. Methods: In all, 20 adult, red-colored-latex-injected hands were studied. Dissections were performed with a 4X to 10X magnification. Cutaneous branches in the proximal half of the HE were found. Their variants were studied, and they were classified into different types according to their relationships. Results: A cutaneous branch of the deep palmar artery (CBDPA) was identified. It was located in the subcutaneous cellular tissue thickness in the proximal half of the HE. Moreover, it presented 3 anatomical variants, classified according to its relationships with the superficial ulnar nerve branch (SUN). Type 1 variant: the CBDPA and the PDA ran in front of the SUN (60% of cases). Type 2: the CBDPA and the DPA ran behind the SUN (30% of cases). Type 3: the CBDPA ran in front of the SUN while the DPA ran behind it (10% of cases). Conclusion: There is a CBDPA which is the HE proximal half main cutaneous branch. Although it presented several variants, its existence is constant, making it possible to use it as pedicle for proximal hypothenar flaps.
Applying Intersectionality With Constructive Grounded Theory as an Innovative Research Approach for Studying Complex Populations: Demonstrating Congruency
Authors: Kassam Shahin , Marcellus Lenora , Clark Nancy , O’Mahony Joyce
Published: January 2020

One goal of qualitative health research is to fully capture and understand stories of people who experience inequities shaped by complex interlocking structural and social determinants. With this social justice–oriented goal in mind, it is critical to use a methodological approach that appreciates prevailing inequities and oppression. In this article, we propose an innovative approach that joins qualitative health research methodology with critical inquiry. Specifically, we propose advancing constructive grounded theory (CGT) through applying intersectionality as an emergent critical social theory and an analytical tool. With our proposed approach being novel, minimal attempts to conceptualize and operationalize CGT with intersectionality exist. This article focuses on initiating theoretical conceptualization through focusing on demonstrating congruency. We are guided by this focus to seek connectedness and fit through analyzing historical and philosophical assumptions of CGT and intersectionality. In our article, we demonstrate congruency within four units of analysis: reflexivity, complexity, variability, and social justice. Through these units, we offer implications to applying intersectionality within CGT methodology. These include a foundation that guides researchers toward further conceptualizing and operationalizing this novel research approach. Implications also include innovatively exploring complex population groups who face structural inequities that shape their lived vulnerabilities. Our proposed research approach supports critical reflection on the research process to consider what shapes the researcher–participant relationship. This includes reflecting on analysis of power dynamics, underlying ideologies, and intermingling social locations. Thus, our conceptual paper addresses the call for evolving social justice methodologies toward inquiring into complex populations and generating knowledge that challenges and resists inequity.
Concordance and prevalence of subclinical atherosclerosis in different vascular territories
Authors: Moreyra Eduardo , Moreyra Camila , Tibaldi Miguel A , Crespo Florencia , Arias Viviana , Lepori Augusto J , Moreyra Eduardo A
Published: January 2020

Background

Subclinical atherosclerosis (SA) in the carotid, femoral, and coronary territories is a powerful predictor of cardiovascular (CV) events. Whether it is sufficient to assess SA in a single vascular territory in early-stage disease is uncertain. We aimed to determine the prevalence and concordance of SA in these vascular beds in asymptomatic patients without known CV disease.

Methods

We enrolled patients aged 35 to 75 years who were asymptomatic, without known CV disease, and had undergone carotid and femoral Doppler ultrasonography and calcium scoring. Those receiving statins were excluded. SA was defined as the presence of plaques in the carotid and/or femoral arteries or the presence of calcium in the coronary arteries (Agatston score >0).

Results

A total of 212 patients were identified with a mean age of 53 ± 7 years, of which 60% (128 patients) were men. The prevalence of SA was 62%. The distribution of SA between the three territories was similar, involving the carotid territory in 38% of cases, the femoral in 31%, and the coronaries in 37%. The concordance between the different vascular territories was weak, with a k index of 0.21 between the coronary and carotid territories, 0.27 between the coronary and femoral territories, and 0.34 between the carotid and femoral territories.

Conclusions

The prevalence of SA in asymptomatic patients without known CV disease is high. The concordance in the presence of SA between the three vascular territories is weak. Therefore, all three vascular beds need to be investigated.
Anxiolytic effects of polydatin through the blockade of neuroinflammation in a chronic pain mouse model
Authors: Guan Shao-Yu , Zhang Kun , Wang Xin-Shang , Yang Le , Feng Bin , Tian Dan-Dan , Gao Mei-Rong , Liu Shui-Bing , Liu An , Zhao Ming-Gao
Published: January 2020

Background

Chronic pain is frequently comorbid with anxiety disorder, thereby complicating its treatment. Polydatin, a component from the root of Polygonum cuspidatum, has shown neuroprotection in the central nervous system. However, its effects on pain and anxiety processing have been rarely investigated. In this study, mice were injected with complete Freund’s adjuvant (CFA) at the hindpaw to induce pain- and anxiety-like behaviors.

Results

Treatment with polydatin (25 mg/kg) alleviated the anxiety-like behaviors but not pain perception in these mice. Polydatin treatment reversed the upregulation of N-methyl-D-aspartic acid receptors and GluA1-containing α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptors in the amygdala of CFA-injected mice. Additionally, this treatment reduced the levels of proinflammatory cytokines, namely, tumor necrosis factor-alpha and interleukin-1β, in the amygdala. Furthermore, activated nuclear factor kappa-B signaling was blocked in the amygdala from CFA-injected mice. By using docking technology, we found potential structural binding between polydatin and IκB kinase beta.

Conclusion

This study indicates the anxiolytic effects of polydatin by suppressing inflammatory cytokines in the amygdala.
Internationalization in the context of academic capitalism
Authors: Appe Susan
Published: January 2020

This article is written from the perspective of a faculty member in a professional graduate degree program who is committed to internationalization, but also notes its challenges given the context in which higher education finds itself. First, the article outlines the ways in which higher education is thinking about internationalization, in particular with a focus on faculty-led short-term study abroad programs. Second, the article juxtaposes internationalization with the current conversation and debates about academic capitalism. Finally, it ends with overarching topics that deserve further exploration and include: (a) that internationalization is often tailored to faculty interests but that this might make systemic assessment challenging; (b) that there are shifting relations among the university central offices related to internationalization processes and academic departments; and (c) given the academic capitalism debates, the article asks whether we can implement and assess our internationalization processes while still adhering to academic quality and credibility.
Acute compartment syndrome of the forearm associated with transradial coronary intervention
Authors: Lee Young-Keun , Lee Se-Hwan , Kwon Tae-Young
Published: January 2020

This study documents our experience with acute forearm compartment syndrome after percutaneous transradial coronary artery intervention and suggests several strategies to achieve good results. A retrospective review identified the medical records of four patients with acute forearm compartment syndrome after transradial intervention who were treated by urgent fasciotomy. The mean time from the onset of symptoms to operation was 5.7 hours. In three cases bleeding was from radial artery rupture at the puncture site, and one case was caused by brachial artery rupture at the level of the distal humerus and radial artery rupture at the level of proximal forearm. We obtained satisfactory results without any complications. If acute forearm compartment syndrome after transradial intervention is diagnosed, the site of bleeding should be identified preoperatively. Early surgical decompression produced satisfactory results even in elderly patients.

Level of evidence: IV
Success story of a case of arthrogryposis multiplex congenita with restrictive lung disease who underwent pulmonary rehabilitation using a robotic patient-guided suspension system
Authors: Tay San San , Visperas Christine Alejandro , Zaw Ei Mon , Abideen Abbas Zainul , Mohd Noor Imran
Published: January 2020

We present a case report of a 31-year-old female with arthrogryposis multiplex congenita who suffered from restrictive lung disease and who underwent pulmonary rehabilitation successfully with a robotic device. This device falls into the category of a patient-guided suspension system. The patient was admitted to the intensive care unit after an episode of pneumonia. In the general ward, she could not be weaned off oxygen and was not able to ambulate more than 3 m with assistance. During the first session of training with the robotic device, she ambulated 162 m. After six sessions of robotic therapy, she was weaned off oxygen and could walk independently. The use of patient-guided suspension systems should be explored in pulmonary rehabilitation.
Limiting mutual trust on fundamental rights grounds under the European arrest warrant and lessons learned from transfers under Dublin III
Authors: Billing Fenella M. W.
Published: January 2020

The Court of Justice of the European Union (CJEU) has examined the limitation of the principle of mutual trust in European arrest warrant (EAW) cases in a number of recent decisions. The court has found that when the executing judicial authority possesses information demonstrating that the requested person is at a real risk of violation of the right to be free from inhuman or degrading treatment guaranteed in art 4 of the Charter of Fundamental Rights of the European Union, then the individual should not be automatically surrendered. Instead, the proceedings should be postponed to obtain supplementary information or discontinued if the risk cannot be discounted. The ‘real risk’ test has also been extended to non-absolute rights, such as the right to a fair trial. However, the CJEU’s reasoning about the limitation of mutual trust is not yet fully formed in relation to certain aspects concerning the nature of fundamental rights and the EAW procedure. This article explores these gaps of understanding about the scope of the limitation on mutual trust in surrender cases and, in doing so, assesses the consistency of similar developments in the area of transfers of asylum seekers under the Dublin Regulation III.
Who am ‘I’: Reauthoring self, stories and subjectivity in research with children
Authors: Thomas Donna M
Published: January 2020

The ‘new’ sociology of childhood sees an emergence of interdisciplinary approaches to understanding self, experience and subjectivity of children. As debates frame research with children, concerned with ‘ethics’ and ‘agency’, what is meant by the ‘subject’ of experience is given little attention. In this article, I ask whether narratives are a true representation of ‘self’; who is the ‘experiencer’ that stories refer to and what are the implications for claiming subjectivity through narrative structures? I suggest that ‘experience’ is an irreducible quality of reality that transcends personal self, and that a core subjectivity serves as the dative of experience, ‘ as natures sole ontological primitive. Understanding self, experience and subjectivity in line with an “Analytical Idealism”’, offers fresh insight into current sociological debates in Childhood Studies.
Therapeutic Response of Extracorporeal Shock Wave Therapy for Insertional Achilles Tendinopathy Between Sports-Active and Nonsports-Active Patients With 5-Year Follow-up
Authors: Zhang Shurong , Li Hong , Yao Wei , Hua Yinghui , Li Yunxia
Published: January 2020

Background:

Insertional Achilles tendinopathy (IAT) is a common cause of posterior heel pain. Extracorporeal shock wave therapy (ESWT) has proven to be an effective treatment, but the relationship between therapeutic responses and sports activity levels has not been studied.

Purpose:

To compare the clinical outcomes of ESWT used to treat IATs between sports-active and nonsports-active patients over 5 years.

Study Design:

Cohort study; Level of evidence, 3.

Methods:

A retrospective study was conducted on 33 patients with IAT who received ESWT from October 2012 to September 2013. Patients were classified into 2 groups according to their preinjury Tegner activity level: a sports-active group, defined as patients who self-reported to be regular joggers (SA group; Tegner activity level >3; n = 16), and a nonsports-active group (control group; Tegner activity level ≤3; n = 17). The mean age was 31 ± 7 years for the SA group and 37 ± 10 years for the control group. The Victorian Institute of Sports Assessment–Achilles (VISA-A) questionnaire scores and visual analog scale (VAS) pain scores were used to evaluate the clinical outcomes before treatment, immediately after treatment, and 5 years after treatment. Ultrasonography was also used to assess the insertional Achilles tendon quality.

Results:

Before treatment, there were no significant differences between the groups with regard to VAS scores, while the VISA-A score in the SA group was higher than that in the control group. After ESWT, both groups had increased VISA-A scores and decreased VAS scores, indicating improvement. At 5-year follow-up, the SA group had a significantly lower mean VAS score (0.3 ± 0.8 vs 1.6 ± 1.3; P = .001) and a significantly higher mean VISA-A score (90 ± 4 vs 78 ± 7; P < .001) compared with the control group. There was no significant difference between the groups regarding the calcification and neovascularization of the Achilles tendon based on ultrasonography.

Conclusion:

ESWT can improve the symptoms of Achilles tendinopathy, and patients with IAT who had greater sports activity levels had better therapeutic responses than nonsports-active patients after 5-year follow-up.
Commuting Distance and Work-to-Family Conflict: The Moderating Role of Residential Attributes
Authors: Montazer Shirin , Young Marisa
Published: January 2020

Commuting is a boundary-spanning demand that can limit employees’ availability to fulfill family-related roles and routines, leading to work-to-family conflict (WFC). We argue that in cities with challenging housing markets, implications of commuting for WFC may vary by residential attributes, and that the moderating effects of residential attributes may vary by gender due to differences in the work-family interface. Analyses of survey data from individuals in the Greater Toronto Area suggest that (1) the positive association between commuting and WFC is stronger among those who are dissatisfied with their place of residence and live in more disordered neighborhoods, irrespective of gender; (2) homeownership protects against the negative impact of commuting distance on WFC—but only among men; and (3) alternatively, the positive association between commuting and WFC becomes stronger as neighborhood quality increases—but only among women. Our study underscores the importance of “compensation” by positive residential qualities in the relationship between commuting and WFC.
Living With Obesity: Expressions of Longing
Authors: Ueland Venke , Dysvik Elin , Furnes Bodil
Published: January 2020

Those who are obese experience complex moral distress. The norm in Western societies is to be slim, and people living with obesity experience challenges under the gaze of society. They feel great vulnerability and the available treatments seldom meet individual needs. New concepts of embodiment need to be developed to include phenomenological investigations. There is limited knowledge about longing among those suffering from obesity. A deeper understanding of longing from an individual perspective is required to improve treatment. The aim of this study was to gain an in-depth understanding of the experiences of longing by those suffering from obesity. The research was approved by the Norwegian Regional Committees for Medical and Health Research Ethics. An explorative phenomenological–hermeneutical design was used. Qualitative interviews were conducted with 18 participants, all with body mass indexes in the range of 30 to 45, which were then analyzed using a phenomenological–hermeneutical approach. Three main dimensions of longing were revealed: longing for normality, longing for what was lost, and longing for simplicity in life. The health service needs to understand better the longings of obese individuals to help them live their lives in greater freedom, based on their own longings and self-care. Focusing on longing may reveal a person’s true desires, and the longing may be a form of resistance to the disciplination of society.
Therapeutic molecular targets of SSc-ILD
Authors: Zhang Yun , Distler Jörg HW
Published: January 2020

Systemic sclerosis is a fibrosing chronic connective tissue disease of unknown etiology. A major hallmark of systemic sclerosis is the uncontrolled and persistent activation of fibroblasts, which release excessive amounts of extracellular matrix, lead to organ dysfunction, and cause high mobility and motility of patients. Systemic sclerosis–associated interstitial lung disease is one of the most common fibrotic organ manifestations in systemic sclerosis and a major cause of death. Treatment options for systemic sclerosis–associated interstitial lung disease and other fibrotic manifestations, however, remain very limited. Thus, there is a huge medical need for effective therapies that target tissue fibrosis, vascular alterations, inflammation, and autoimmune disease in systemic sclerosis–associated interstitial lung disease. In this review, we discuss data suggesting therapeutic ways to target different genes in distinct tissues/organs that contribute to the development of SSc.
Obtaining Unbiased Results in Meta-Analysis: The Importance of Correcting for Statistical Artifacts
Authors: Wiernik Brenton M. , Dahlke Jeffrey A.
Published: January 2020

Most published meta-analyses address only artifactual variance due to sampling error and ignore the role of other statistical and psychometric artifacts, such as measurement error variance (due to factors including unreliability of measurements, group misclassification, and variable treatment strength) and selection effects (including range restriction or enhancement and collider biases). These artifacts can have severe biasing effects on the results of individual studies and meta-analyses. Failing to account for these artifacts can lead to inaccurate conclusions about the mean effect size and between-studies effect-size heterogeneity, and can influence the results of meta-regression, publication-bias, and sensitivity analyses. In this article, we provide a brief introduction to the biasing effects of measurement error variance and selection effects and their relevance to a variety of research designs. We describe how to estimate the effects of these artifacts in different research designs and correct for their impacts in primary studies and meta-analyses. We consider meta-analyses of correlations, observational group differences, and experimental effects. We provide R code to implement the corrections described.
Immune profiles in acute myeloid leukemia bone marrow associate with patient age, T-cell receptor clonality, and survival
Authors: Brück Oscar , Dufva Olli , Hohtari Helena , Blom Sami , Turkki Riku , Ilander Mette , Kovanen Panu , Pallaud Celine , Ramos Pedro Marques , Lähteenmäki Hanna , Välimäki Katja , El Missiry Mohamed , Ribeiro Antonio , Kallioniemi Olli , Porkka Kimmo , Pellinen Teijo , Mustjoki Satu
Published: January 2020

The immunologic microenvironment in various solid tumors is aberrant and correlates with clinical survival. Here, we present a comprehensive analysis of the immune environment of acute myeloid leukemia (AML) bone marrow (BM) at diagnosis. We compared the immunologic landscape of formalin-fixed paraffin-embedded BM trephine samples from AML (n = 69), chronic myeloid leukemia (CML; n = 56), and B-cell acute lymphoblastic leukemia (B-ALL) patients (n = 52) at diagnosis to controls (n = 12) with 30 immunophenotype markers using multiplex immunohistochemistry and computerized image analysis. We identified distinct immunologic profiles specific for leukemia subtypes and controls enabling accurate classification of AML (area under the curve [AUC] = 1.0), CML (AUC = 0.99), B-ALL (AUC = 0.96), and control subjects (AUC = 1.0). Interestingly, 2 major immunologic AML clusters differing in age, T-cell receptor clonality, and survival were discovered. A low proportion of regulatory T cells and pSTAT1+cMAF− monocytes were identified as novel biomarkers of superior event-free survival in intensively treated AML patients. Moreover, we demonstrated that AML BM and peripheral blood samples are dissimilar in terms of immune cell phenotypes. To conclude, our study shows that the immunologic landscape considerably varies by leukemia subtype suggesting disease-specific immunoregulation. Furthermore, the association of the AML immune microenvironment with clinical parameters suggests a rationale for including immunologic parameters to improve disease classification or even patient risk stratification.