bluuebunny/crossref_metadata_2025 huggingface dataset:
The Obesity-associated Risk in Open and Endovascular Repair of Abdominal Aortic Aneurysm
Authors: Radak Djordje , Tanaskovic Slobodan , Neskovic Mihailo
Published: July 2019

:

The rising pandemic of obesity in modern society should direct attention to a more comprehensive approach to abdominal aortic aneurysm (AAA) treatment in the affected population. Although overweight patients are considered prone to increased surgical risk, studies on the subject did not confirm or specify the risks well enough.

:

Associated comorbidities inevitably lead to a selection bias leaning towards endovascular abdominal aortic repair (EVAR), as a less invasive treatment option, which makes it hard to single out obesity as an independent risk factor. The increased technical difficulty often results in prolonged procedure times and increased blood loss. Several smaller studies and two analyses of national registries, including 7935 patients, highlighted the advantages of EVAR over open repair (OR) of abdominal aortic aneurysm, especially in morbidly obese population (relative risk reduction up to 47%). On the other hand, two other studies with 1374 patients combined, concluded that EVAR might not have an advantage over OR in obese patients (P = 0.52). Obesity is an established risk factor for wound infection after both EVAR and OR, which is associated with longer length of stay, subsequent major operations, and a higher rate of graft failure. Percutaneous EVAR technique could present a promising solution to reducing this complication.

:

EVAR seems like a more feasible treatment option than OR for obese patients with AAA, due to lower overall morbidity and mortality rates, as well as reduced wound-related complication rates. However, there is a clear lack of high-quality evidence on the subject, thus future prospective trials are needed to confirm this advantage.
Rhizoma Coptidis for Alzheimer’s Disease and Vascular Dementia: A Literature Review
Authors: Wang Zhiyong , Yang Yang , Liu Meixia , Wei Yun , Liu Jiangang , Pei Hui , Li Hao
Published: July 2019

Background:

Alzheimer’s disease (AD) and vascular dementia (VaD) are major types of
dementia, both of which cause heavy economic burdens for families and society. However, no currently
available medicines can control dementia progression. Rhizoma coptidis, a Chinese herbal medicine, has
been used for >2000 years and is now gaining attention as a potential treatment for AD and VaD.

Methods:

We reviewed the mechanisms of the active ingredients of Rhizoma coptidis and Rhizoma
coptidis-containing Chinese herbal compounds in the treatment of AD and VaD. We focused on studies
on ameliorating the risk factors and the pathological changes of these diseases.

Results:

The Rhizoma coptidis active ingredients include berberine, palmatine, coptisine, epiberberine,
jatrorrhizine and protopine. The most widely studied ingredient is berberine, which has extensive therapeutic
effects on the risk factors and pathogenesis of dementia. It can control blood glucose and lipid
levels, regulate blood pressure, ameliorate atherosclerosis, inhibit cholinesterase activity, Aβ generation,
and tau hyperphosphorylation, decrease neuroinflammation and oxidative stress and alleviate cognitive
impairment. Other ingredients (such as jatrorrhizine, coptisine, epiberberine and palmatine) also regulate
blood lipids and blood pressure; however, there are relatively few studies on them. Rhizoma
coptidis-containing Chinese herbal compounds like Huanglian-Jie-Du-Tang, Huanglian Wendan Decoction,
Banxia Xiexin Decoction and Huannao Yicong Formula have anti-inflammatory and antioxidant
stress activities, regulate insulin signaling, inhibit γ-secretase activity, neuronal apoptosis, tau hyperphosphorylation,
and Aβ deposition, and promote neural stem cell differentiation, thereby improving
cognitive function.

Conclusion:

The “One-Molecule, One-Target” paradigm has suffered heavy setbacks, but a “multitarget-
directed ligands” strategy may be viable. Rhizoma coptidis active ingredients and Rhizoma coptidiscontaining
Chinese herbal compounds have multi-aspect therapeutic effects on AD and VaD.
Synthesis of Spiro[cycloalkane-pyridazinones] with High Fsp3 Character
Authors: Für Csilla Sepsey , Riszter Gergő , Gerencsér János , Szigetvári Áron , Dékány Miklós , Hazai László , Keglevich György , Bölcskei Hedvig
Published: July 2019

Background:

owadays, in course of the drug design and discovery much attention is
paid to the physicochemical parameters of a drug candidate, in addition to their biological activity.
Disadvantageous physicochemical parameters can hinder the success of a drug candidate.

Objective:

Lovering et al. introduced the Fsp3 character as a measure of carbon bond saturation,
which is related to the physicochemical paramethers of the drug. The pharmaceutical research focuses
on the synthesis of compounds with high Fsp3 character.

Methods:

To improve the physicochemical properties (clogP, solubility, more advantageous ADME
profile, etc.) of drug-candidate molecules one possibility is the replacement of all-carbon aromatic
systems with bioisoster heteroaromatic moieties, e.g. with one or two nitrogen atom containing systems,
such as pyridines and pyridazines, etc. The other option is to increase the Fsp3 character of the
drug candidates. Both of these aspects were considered in the design the new spiro[cycloalkanepyridazinones],
the synthesis of which is described in the present study.

Results:

Starting from 2-oxaspiro[4.5]decane-1,3-dione or 2-oxaspiro[4.4]nonane-1,3-dione, the
corresponding ketocarboxylic acids were obtained by Friedel-Crafts reaction with anisole or veratrole.
The ketocarboxylic acids were treated by hydrazine, methylhydrazine or phenylhydrazine to form
the pyridazinone ring. N-Alkylation reaction of the pyridazinones resulted in the formation of further
derivatives with high Fsp3 character.

Conclusion:

A small compound library was obtained incorporating compounds with high Fsp3 characters,
which predicts advantageous physico-chemical parameters (LogP, ClogP and TPSA) for potential
applications in medicinal chemistry.
Microwave-assisted Synthesis and Docking Studies of Phenylureas as Candidates for the Drug Design Against the Biological Warfare Agent Yersinia Pestis
Authors: França Tanos Celmar Costa , Bastos Leonardo da Costa , Cuya Teobaldo , Sirouspour Mehdi , Chacón-Huete Franklin , Bendahan David , Forgione Pat
Published: July 2019

Background:

Bubonic plague is amongst the diseases with the highest potential for being
used in biological warfare attacks today. This disease, caused by the bacterium Yersina pestis, is
highly infectious and can achieve 100% of fatal victims when in its most dangerous form. Besides,
there is no effective vaccine, and the chemotherapy available today against plague is ineffective if
not administered at the beginning of the infection.

Objective:

Willing to contribute for changing this reality we propose here new phenylureas as candidates
for the drug design against plague meant to target the enzyme dihydrofolate reductase from
Y. pestis (YpDHFR).

Methods:

Seven phenylureas, four of them new, were synthesized, following synthetic routes
adapted from procedures available in the literature, and using microwave irradiation. After, they
were submitted to docking studies inside YpDHFR and human DHFR (HssDHFR) in order to check
their potential as selective inhibitors.

Results:

Our results revealed four new phenylureas and a new synthetic route for this kind of molecule
using microwave irradiation. Also, our docking studies showed that these compounds are capable
of binding to both HssDHFR and YpDHFR, with U1 - U4 and U23 showing more selectivity for
HssDHFR and U7, U8 being more selective towards YpDHFR.

Conclusion:

We reported the synthesis with good yields of seven phenylureas, following a simple
and clean alternative synthetic route using microwave irradiation. Further molecular docking studies
of our compounds suggested that two are capable of binding more selectivity to YpDHFR, qualifying
as potential candidates for the drug design of new drugs against plague.
Synthesis, In Silico and In Vivo Evaluation of Novel 1, 3, 4-Thiadiazole Analogues as Novel Anticancer Agents
Authors: Krishna Swathi , Gowramma Byran , Mohammed Manal , Kalirajan Rajagopal , Kaviarasan Lakshman , Praveen Thaggikuppe Krishnamurthy
Published: July 2019

Background:

1,3,4-thiadiazole is a lead molécule which is versatile for a wide variety of
biological activities and in continuation of our interest in establishing some novel heterocyclic compounds
for antitumor activity.

Objective:

The objective of the study was to synthesize series of 5-(1,3-benzodioxol-5-yl)-1,3,4-
thiadiazol-2-amine derivative and evaluated for their possible in vitro and in vivo anticancer activity.

Methods:

The synthesis of 2-aminonaphthoxy-1,3,4-thiadiazole and 5-(1,3-benzodioxol-5-yl)-1,3,4-
thiadiazol-2-amine as intermediates were carried out by cyclization method. A mixture of thiosemicarbazide
and naphthoxyacetic acid/piperonylic acid and phosphoryl chloride were subjected to cyclization
with phosphorous oxychloride to obtain compound 3. Further compounds 1 and 3 were
reacted with different aromatic aldehydes in methanol to form compounds 2a-e and 4a-e. The compounds
2a-e and 4a-e were characterized for the melting points, IR, Proton NMR and Mass spectra.
The compounds were further evaluated for their anticancer activity. The docking study was performed
using Discovery studio 4.1 (Accelrys) software against DNA-binding domain of STAT3.
The compounds were analyzed for the ligand-protein binding interaction(s) by molecular docking
into the active site of STAT3β using the CDOCKER protocol of Discovery studio (v4.1).

Results:

The title compounds were screened for in vitro anticancer on human breastadenocarcinoma
cells (MCF-7 and Vero). Compounds 4c, 4d and 2d against MCF 7 and 4d against Vero cell lines
were found to be the most active dérivatives with IC50 values of 1.03, 2.81 and 3.45 µg/ml against
MCF 7 and 31.81 µg/ml against Vero cell lines, respectively.

Conclusion:

From the in vivo anticancer studies, it was concluded that the synthesized compounds
4c and 4d displayed anticancer activity comparable to the standard drug, while the rest of the compounds
demonstrated mild potency for anticancer studies.
Diabetes and Parkinson’s Disease: Debating the Link Through Ca2+/cAMP Signalling
Authors: Bergantin Leandro B.
Published: July 2019

Background:

A link between diabetes and Parkinson´s disease (PD) has been established by several reports. Consistent data report that people diagnosed with diabetes have demonstrated an enhanced risk of manifesting PD in their lifetime. The working principles involved in this link have been extensively discussed. Over the last decade, diabetes has been reported to be correlated with an increased risk of dementia, suggesting a potential role of diabetes, or insulin signalling dysregulations, in neurodegeneration. In addition, it is nowadays highly debated that dysregulations related to Ca2+ signalling may be an upstream issue which could also link diabetes and PD. Ca2+ and cAMP signalling pathways (Ca2+/cAMP signalling) control both the neurotransmitters/hormones release and neuronal death.

Conclusion:

Considering our previous reports about Ca2+/cAMP signalling, the putative contribution of Ca2+/cAMP signalling in this link (between diabetes and PD) is discussed in this paper.
Kisspeptin and the “Special Relationship” Between Reproduction and Metabolism: A Computational Approach
Authors: Lambrou George I. , Bacopoulou Flora
Published: July 2019

Background:

Kisspeptin is one of the most potent stimulators of GnRH secretion and
consequent gonadotropin release from the anterior pituitary. Kisspeptin is considered critical in
regulating reproductive function in relation to metabolic cues. Reproductive function is gated by
the energy reserves of the individual. Conditions of energy insufficiency, such as Anorexia Nervosa,
often disturb reproductive function and fertility.

Objective:

The aim of this research was to investigate similar or comparable hormonal patterns in
kisspeptin mechanics using computational methodology tools.

Methods:

Twenty-two females with typical or atypical anorexia nervosa and fifteen control females,
were recruited from the Center for Adolescent Medicine of the University of Athens. Serum
levels of Prolactin (PRL), 17-Hydroxy-Progesterone (17OHPR), Free Triiodothyronine (FT3), Triiodothyronine
(T3), Free Thyroxine (FT4), Thyroid Stimulating Hormone (TSH), Luteinizing
Hormone (LH), Follicle Stimulating Hormone (FSH) and Estradiol (E2) were measured in patients
and controls. Data were modelled computationally in order to find similar or comparable patterns
between control and anorexic participants, with respect to kisspeptin.

Results:

Kisspeptin manifested symmetrical regression plots between controls and anorexics with
respect to 17OHPR, LH and FSH, as well as a threshold pattern among controls, typical and atypical
anorexics.

Conclusions:

Kisspeptin seems to participate in the anorexic hormonal milieu through threshold or
symmetrical mechanisms.
Structure and Characteristics of Electrospun ZnO Nanofibers for Gas Sensing
Authors: Lai Tang-Yu , Fang Te-Hua , Hsiao Yu-Jen , Kuo En-Yu
Published: July 2019

Background::

A sensing material of zinc oxide (ZnO) was investigated for its use in the
electrospun nanofibers for gas sensing. The metal oxide semiconductor gas sensor response is caused
by the oxygen that undergoes a chemical reaction on the surface of an oxide, resulting in a change in
the measured resistance.

Objective::

One-dimensional nanofibers gas sensor have high sensitivity and diverse selectivity.

Methods::

One-dimensional nanofiber by an electrospinning method was collected and a sensing
membrane was formed. In addition, the gas sensing mechanism was discussed and verified by X-ray
photoelectron spectroscopy (XPS).

Results::

The ZnO nanofiber membrane had an optimum crystalline phase with a lattice spacing of
0.245 nm and a non-woven fabric structure at a calcination temperature of 500°C, whereas the nanofiber
diameter and membrane thickness were about 100 nm and 8 μm, respectively. At an operating
temperature of 200°C, the sensing material exhibited good recovery and reproducibility in response
to Carbon monoxide (CO), and the concentration was also highly discernible. In addition, the reduction
in the peak of OIII at 531.5 to 532.5 eV according to the analysis of XPS was consistent with the
description of the sensing mechanism.

Conclusion::

The gas sensor of ZnO nanofiber membranes has high sensitivity and diverse selectivity,
which can be widely applied in potential applications in various sensors and devices.
High Flow Through Nasal Cannula in Stable and Exacerbated Chronic Obstructive Pulmonary Disease Patients
Authors: Bruni Andrea , Garofalo Eugenio , Cammarota Gianmaria , Murabito Paolo , Astuto Marinella , Navalesi Paolo , Luzza Francesco , Abenavoli Ludovico , Longhini Federico
Published: July 2019

Background:

High-Flow through Nasal Cannula (HFNC) is a system delivering heated humidified air-oxygen mixture at a flow up to 60 L/min. Despite increasing evidence in hypoxemic acute respiratory failure, a few is currently known in chronic obstructive pulmonary disease (COPD) patients.

Objective:

To describe the rationale and physiologic advantages of HFNC in COPD patients, and to systematically review the literature on the use of HFNC in stable and exacerbated COPD patients, separately.

Methods:

A search strategy was launched on MEDLINE. Two authors separately screened all potential references. All (randomized, non-randomized and quasi-randomized) trials dealing with the use of HFNC in both stable and exacerbated COPD patients in MEDLINE have been included in the review.

Results:

Twenty-six studies have been included. HFNC: 1) provides heated and humidified airoxygen admixture; 2) washes out the anatomical dead space of the upper airway; 3) generates a small positive end-expiratory pressure; 4) guarantees a more stable inspired oxygen fraction, as compared to conventional oxygen therapy (COT); and 5) is more comfortable as compared to both COT and non-invasive ventilation (NIV).

:

In stable COPD patients, HFNC improves gas exchange, the quality of life and dyspnea with a reduced cost of muscle energy expenditure, compared to COT. In exacerbated COPD patients, HFNC may be an alternative to NIV (in case of intolerance) and to COT at extubation or NIV withdrawal.

Conclusion:

Though evidence of superiority still lacks and further studies are necessary, HFNC might play a role in the treatment of both stable and exacerbated COPD patients.
The Protective Mechanism of Cannabidiol in Cardiac Injury: A Systematic Review of Non-Clinical Studies
Authors: Shayesteh Mohammad R.H. , Haghi-Aminjan Hamed , Mousavi Mohammad J. , Momtaz Saeideh , Abdollahi Mohammad
Published: July 2019

Background:

Cardiac disease is accounted as the leading cause of worldwide morbidity and mortality.
The disease is characterized by the overproduction of reactive oxygen and/or nitrogen species (ROS/RNS), and
induction of oxidative stress. Cannabidiol (CBD) is a non-psychoactive ingredient of marijuana that has been
reported to be safe and well tolerated in patients. Due to its pleiotropic effect, CBD has been shown to exert cytoprotective
effects. This study intended to clarify the mechanisms and the potential role of CBD regarding cardiac
injuries treatment.

Methods:

A systematic literature search was conducted, according to the Preferred Reporting Items for Systematic
Reviews and Meta-Analyses (PRISMA) guidelines, in the electronic databases including PubMed, Web of
Science, Scopus, and Embase up to June 2019 using predefined search terms in the titles and abstracts. Accordingly,
a set of pre-specified inclusion and exclusion criteria were considered and 8 articles were ultimately included
in this study.

Results:

Our findings demonstrate that CBD has multi-functional protective assets to improve cardiac injuries;
preliminary through scavenging of free radicals, and reduction of oxidative stress, apoptosis, and inflammation.

Conclusion:

CBD can protect against cardiac injuries, mainly through its antioxidative and antiapoptotic effects
on the basis of non-clinical studies. The cardioprotective effects of the CBD need to be further studied in welldesigned
clinical trials.
Augmenting the Operations on Cloud Virtual Forensic Data by Employing Probabilistic Data Structures
Authors: Pandi Gayatri S. , Shah Saurabh , Wandra K.H.
Published: July 2019

Background:

Gathering and scrutinizing the different types of logs are the vital steps in
the forensic domain. Logs are commonly gathered by the cloud service providers or by some third
party layers which are governed by the cloud service providers. Security of the logs is a crucial
issue as the logs can be tampered accidentally or intentionally by an employee in the cloud service
provider’s organization or by the forensic investigator.

Objective:

The algorithm designed assists in verifying the tampering of the virtual instance logs
which can be accidental or intentional. Verification process confirms that the confidentiality and
integrity of the logs remains intact. Verification of the potential evidence for past logs is normally
carried out by the forensic investigator and the auditor.

Methods:

The uniqueness of the research conducted in this paper is a technique which employs
the cuckoo filter, which is supportive in proving the integrity of the potential evidences for past
logs at a faster pace. The probabilistic data structures cuckoo filter and the bloom filter also support
the concealment of logs.

Results:

The implemented system and the results observed in it, are very promising in the cloud
forensic domain. The performance of the algorithm is better than the earlier system implemented
with the log chain and the database.

Conclusion:

The secure framework designed in this research paper aids in proving the integrity of
the virtual instance logs. The evidence verification process supports concealment of data also.
Spectrum Sensing of FH Signals Using Canonical Correlation Analysis Based Eigen Value Interpolation Over Nakagami-m Fading Channel
Authors: Sharma Sandeep , Verma Himani
Published: July 2019

Aims:

In the context of modern times where most of the network infrastructure is technology
dependent, it becomes imperative to cumulate the perceptive regarding the contrivance of the concept of
correlational analysis in communication domain as well. Hence, a Canonical Corelational Analysis (CCA)
based Signal-to-Noise Ratio (SNR) estimation scheme for Frequency Hopped (FH) signals amidst a sumof-
sinusoids based Nakagami- m fading channel is proposed.

Objective:

Spectrum Sensing (SS) is enunciated using maximum eigenvalue of the received signal’s covariance
matrix obtained by the proposed CCA approach.

Methods:

The SNR of the sensed FH signals is evaluated using a conventional moment-based M2M4
technique.

Results:

Consequently, on contemplating the outcomes in terms of Normalized Mean Square Error
(NMSE), it can be substantiated that the application of CCA approach is pertinent enough for reliable low
range SNR estimation up to -5dB.

Conclusion:

Meanwhile, due to efficient multivariate analysis, CCA fosters statistical efficiency in terms
of modulation identification that reduces the complexity of computation.
Hybrid Deep Neural Model for Duplicate Question Detection in Trans-Literated Bi-Lingual Data
Authors: Rani Seema , Kumar Avadhesh , Kumar Naresh
Published: July 2019

Background:

Duplicate content often corrupts the filtering mechanism in online question answering. Moreover, as users are usually more comfortable conversing in their native language questions, transliteration adds to the challenges in detecting duplicate questions. This compromises with the response time and increases the answer overload. Thus, it has now become crucial to build clever, intelligent and semantic filters which semantically match linguistically disparate questions.

Objective:

Most of the research on duplicate question detection has been done on mono-lingual, majorly English Q&A platforms. The aim is to build a model which extends the cognitive capabilities of machines to interpret, comprehend and learn features for semantic matching in transliterated bi-lingual Hinglish (Hindi + English) data acquired from different Q&A platforms.

Method:

In the proposed DQDHinglish (Duplicate Question Detection) Model, firstly language transformation
(transliteration & translation) is done to convert the bi-lingual transliterated question into a monolingual
English only text. Next, a hybrid of Siamese neural network containing two identical Long-Term-
Short-Memory (LSTM) models and Multi-layer perceptron network is proposed to detect semantically
similar question pairs. Manhattan distance function is used as the similarity measure.

Result:

A dataset was prepared by scrapping 100 question pairs from various social media platforms,
such as Quora and TripAdvisor. The performance of the proposed model on the basis of accuracy and Fscore.
The proposed DQDHinglish achieves a validation accuracy of 82.40%.

Conclusion:

A deep neural model was introduced to find semantic match between English question and a Hinglish (Hindi + English) question such that similar intent questions can be combined to enable fast and efficient information processing and delivery. A dataset was created and the proposed model was evaluated on the basis of performance accuracy. To the best of our knowledge, this work is the first reported study on transliterated Hinglish semantic question matching.
ALGORITHM OF MANAGEMENT OF WATER-PROTECTIVE ACTIVITY OF JSC «SEGEZHA PPM» ON BASIS OF MATHEMATICAL MODELING
Authors: Epifanov A. V. , Epifanova M. A.
Published: July 2019

Modern environmental legislation of the Russian Federation requires the introduction of automated systems for the control of waste and natural waters for large water users, which include JSC «Segezha PPM». The article proposes an algorithm for integrating the current automated process control system of JSC «Segezha PPM» into a unified system of water safety management. The proposed automated control system contains sensors for monitoring the parameters of the production process, the parameters of biological sewage treatment plants, wastewater and Lake Vygozer in the background section. The process of managing water protection activities is based on the use of neural networks, an event tree, and models of convective-diffusive transfer and transformation of substances in water bodies. The implementation of the system will ensure the environmental quality standards of the water body, optimally redistribute the load between water outlets, optimize the parameters of the production process, and form model forecasts of the state of Lake Vygozero.
DEVELOPMENT OF BASIC STRUCTURE FOR QUALITY MANAGEMENT SYSTEM OF TREND POTENTIAL OF COMPLEX TECHNICAL SYSTEM OF UNMANNED AERIAL VEHICLES
Authors: Balashov V. M. , Nazarevich S. A. , Urentsev A. V.
Published: July 2019

In conditions when the volume of government orders for defense products may significantly decline, enterprises of the radioelectronic industry are faced with the need to move to civilian product markets, which will stabilize the order portfolio and reduce macroeconomic and technological risks. The article presents the main approaches to the analysis of the trend potential of complex technical systems on the example of unmanned aerial vehicles. Methods for assessing the quality of complex technical systems at different stages of the development of the potential of complex technical systems in the structure of the life cycle are proposed. A hypothetical fragment of a chronological analysis of the potential state of complex technical systems with a planning horizon of five to ten years is presented. The proposed approaches and mathematical models make it possible to predict the potential and to optimize the consumer characteristics of complex technical systems, based on the requirements of customers, the development of their needs, as well as on the implementation of advanced standardization.
PHYSICAL NATURE OF OCCURRENCE OF LOCAL DEFECTS OF PRODUCTS AND THEIR INFLUENCE ON QUALITY OF FUNCTIONING OF MECHANICAL COMPONENTS
Authors: Ershov D. Yu. , Lukyanenko I. N. , Smirnov A. O.
Published: July 2019

The paper is devoted to the consideration of the main reasons for the failure of various kinds of electromechanical instrument assemblies, caused by the occurrence of local defects in the material of the critical parts. The physical nature of the appearance of such defects, which is caused by discrete inclusions in the materials of parts, is disclosed. The origin of local defects largely affects the appearance of external vibration effects and dynamic processes in the nodes of the mechanisms of the devices and their further functioning and quality of work. A mathematical form of accounting for local defects when creating a mathematical model for describing a node of a mechanical system using Fourier analysis is given. The possible directions of development of local defects in the nodes of the system and the consequences of them are shown, and attention is also focused on the proposed methods for eliminating these defects in the manufacture of parts.
Fortifikasi puree wortel (daucus carotal) sebagai sumber vitamin pada kue celilong
Authors: Wadhani Luh Putu Prema
Published: July 2019

Vitamin A menjadi salah satu zat gizi mikro yang berperan penting dalam proses pertumbuhan dan perkembangan anak. Wortel merupakan salah satu sumber bahan makanan yang mengandung tinggi vitamin A. Masih kurangnya inovasi maupun fortifikasi pada kue tradisional sehingga dibutuhkan fortifikasi atau inovasi terbaru pada kue tradisional. Penelitian ini bertujuan untuk mengetahui mutu sensoris dan kandungan gizi vitamin A pada produk kue tradisional celilong dengan penambahan purre wortel. Penelitian ini merupakan jenis penelitian dan pengembangan (Research and Development) yang menggunakan model 4D yang terdiri dari define, design, development, dan disseminate. Analisis data dalam penelitian ini menggunakan analisis kualitatif dan kuantitatif. Hasil penelitian produk terbaik terdapat pada penambahan puree wortel sebanyak 50%. Kandungan vitamin A dalam 1 porsi produk ini memberikan sumbangan > 100% pada semua kalangan usia yaitu balita, anak, remaja, dewasa dan lansia. Dari hasil uji mutu sensoris pada produk ini telah sesuai dan dapat diterima sesuai dengan kriteria produk yang diinginkan, sehingga penambahan puree wortel dapat diterima dan dapat menjadi sumber vitamin A pada kue tradisional Celilong. AbstractVitamin A is one of the micronutrients that plays an important role in the process of growth and development of children. Carrots are one of the sources of food that contains high vitamin A. There is still a lack of innovation and fortification in traditional cakes so fortification or the latest innovations in traditional cakes are needed. This study aims to determine the sensory quality and nutritional content of vitamin A in traditional celilong cake products with the addition of carrots purre. This research is a type of research and development (Research and Development) that uses a 4D model consisting of define, design, development, and disseminate. Data analysis in this study used qualitative and quantitative analysis. The results of the best product study were found in the addition of 50% carrot puree. The contain of vitamin A in 1 portion of this product contributes > 100% to all ages, namely toddlers, children, adolescents, adults and the elderly. From the results of sensory quality tests on this product it is appropriate and acceptable according to the desired product criteria, so that the addition of carrot puree is acceptable and can be a source of vitamin A in Celilong traditional cakes.
MANFAAT ACCELEROMETER DALAM PENGUKURAN AKTIVITAS FISIK
Authors: Anggunadi Angelica , Sutarina Nora
Published: July 2019

ABSTRAK Berbagai penelitian menunjukkan bahwa terjadinya penyakit kronik di usia lanjut sangat dipengaruhi oleh  gaya hidup tidak aktif atau sedentary yang dijalani oleh individu tersebut pada usia muda. Selain itu aktivitas fisik diketahui sangat bermanfaat mendukung pertumbuhan dan perkembangan yang optimal pada anak dan remaja. Olahraga dan akitivitas fisik adalah hal yang perlu diperhatikan dalam menjaga kesehatan dan mencegah berbagai macam penyakit.Banyak penelitian epidemiologis telah memastikan bahwa aktivitas fisik dapat menurunkan risiko berbagai morbiditas yang berkaitan dengan usia atau penuaan serta risiko mortalitas akibat sebab apapun. Berbagai jenis aktivitas fisik dapat dilakukan namun untuk mendapatkan manfaatnya, beberapa variabel seperti intensitas dan durasi aktivitas fisik yang dilakukan, harus diperhatikan.Aktivitas fisik dengan intensitas yang cukup tinggi (vigorous) dapat menurunkan risiko kematian akibat penyakit jantung koroner sebanyak 30%, atau penurunan risiko kematian akibat stroke atau osteoporosis sebesar 25%. Penelitian tersebut menunjukkan bahwa kita perlu mengetahui apakah intensitas aktivitas aktivitas fisik yang dilakukan sudah mencukupi untuk mendapat kemanfaatan yang optimal.Berbagai metode dan alat yang telah dikembangkan dalam pengukuran intensitas aktivitas fisik. Salah satu metode penilaian aktivitas fisik yang dianggap akurat dan cukup banyak digunakan adalah akselerometer. Artikel ini bertujuan untuk membahas tentang accelerometer dan manfaatnya dalam menilai aktivitas fisik. Kata kunci: accelerometer, aktivitas fisik.
EFEK METODE LATIHAN DRILL TERHADAP KETEPATAN SMASH ATLET BULU TANGKIS BERUSIA MUDA DI YOGYAKARTA
Authors: Wiratama Sukmara Aldo , Karyono Trihadi
Published: July 2019

Penelitian ini bertujuan untuk mengetahui pengaruh metode latihan drill terhadap ketepatan smash atlet bulutangkis putra usia 10-12 tahun di Yogyakarta.            Penelitian ini menggunakan desain eksperimental (pre-post test) dengan sampel sebanyak 9 orang. Instrumen penelitian yang digunakan adalah tes ketepatan smash dari PBSI dan analisis data menggunakan uji-t berpasangan. Intervensi berupa latihan drill dilakukan sebanyak 16 kali dengan frekuensi latihan 6 kali dalam seminggu.            Hasil penelitian menunjukkan terdapat peningkatan yang bermakna secara statistik (p < 0,05) sebesar 61,02 % antara sebelum dan sesudah intervensi. Penelitian ini menunjukkan bahwa metode drill mampu memberikan peningkatan terhadap ketepatan smash pemain bulutangkis diusia muda. Kata kunci : bulu tangis, usia muda, drill, ketepatan smash
PENGARUH PEMBERIAN VITAMIN E TERHADAP KADAR MDA PLASMA DARAH PASCA LATIHAN FISIK SUBMAKSIMAL
Authors: Mulyono Mulyono , Susiloningsih Wahyu
Published: July 2019

In physical activity, in addition to forming free radical compounds, the body will form antibodies in the form of endogenous antioxidants. In the event of an imbalance in the formation of free radicals with antioxidants (oxidative stress) exogenous antioxidant administration will help to restore the balance of free radicals with - antioxidants. Provision of vitamins and massage manipulation immediately after physical exercise is expected to help in decreasing levels of MDA Plasma as one indicator of the degree of free radical in the blood and helps speed up the recovery of the body.It is an experimental research with post-test control group design with sample of 20 college students of Unipa Surabaya. Which is divided into 2 groups with each group amounted to 10 college students. The group is Control group and Vitamin E group. The all group performed 2.4 km run, the treatment was given after the sample did the physical activity. After 1 hour of treatment each group was taken by radially to see blood MDA plasma levels.After processed data got average of plasma MDA level of each group that is control group with mean 8,0870 nmol/ml, vitamin E group with average 2,9020 nmol/ml. From the statistical t test obtained of P value 0.05. Thus, there was significant difference of MDA Plasma level between control group and vitamin E after physical exercise.ABSTRAK Dalam aktivitas fisik, selain membentuk senyawa radikal bebas, tubuh akan membentuk antibodi dalam bentuk antioksidan endogen. Jika terjadi ketidakseimbangan dalam pembentukan radikal bebas dengan antioksidan (oksidatif stres) maka pemberian antioksidan eksogen akan membantu mengembalikan keseimbangan radikal bebas dengan - antioksidan. Penyediaan vitamin dan manipulasi pijat segera setelah latihan fisik diharapkan bisa membantu dalam menurunkan kadar MDA Plasma sebagai salah satu indikator tingkat radikal bebas dalam darah dan membantu mempercepat pemulihan tubuh.Penelitian ini merupakan penelitian eksperimental dengan desain kelompok kontrol post-test dengan sampel 20 mahasiswa Unipa Surabaya. Yang terbagi menjadi 2 kelompok dengan masing-masing kelompok berjumlah 10 mahasiswa. Kelompok ini adalah Kelompok kontrol dan kelompok Vitamin E. Semua kelompok melakukan lari 2,4 km, perlakuan diberikan setelah sampel melakukan aktivitas fisik. Setelah 1 jam pengobatan, masing-masing kelompok diambil secara radial untuk melihat tingkat plasma darah MDA.Setelah data yang diolah didapatkan rata-rata kadar MDA plasma masing-masing kelompok yaitu kelompok kontrol dengan rata-rata 8,0870 nmol/ml, kelompok vitamin E dengan rata-rata 2.9020 nmol/ml. Dari uji statistik diperoleh nilai P 0,05. Dengan demikian ada perbedaan tingkat MDA Plasma yang signifikan antara kelompok kontrol dan vitamin E setelah latihan fisik.Penelitian ini menunjukan bahwa dengan pemberian vitamin E setelah latihan fisik dapat membantu menurunkan kadar MDA Plasma yang merupakan indicator tingkat radikal bebas.
KONTRIBUSI POWER TUNGKAI DAN KECEPATAN REAKSI TERHADAP TENDANGAN MAE GERI PADA ATLET KARATE PUTRI
Authors: Wanda Dian Fitra , Nurseto Frans , Husin Sudirman
Published: July 2019

Penelitian ini bertujuan Untuk mengetahui kontribusi antara power tungkai terhadap hasil tendangan mae geri pada atlet putri bintang jaya mandiri tanjung bintang. Jenis penelitian yang digunakan adalah deskriptif korelasional dengan sampel sebanyak 30 atlet putri. teknik pengumpulan data menggunakan tes dan pengukuran. Hasil penelitian dan analisis menunjukkan rata-rata hasil pengukuran power tungkai atlet putri adalah 2,19, kecepatan reaksi 59,73, kemampuan tendangan mae geri 0,267. Hasil penelitian dapat disimpulkan bahwa power tungkai memberikan kontribusi terhadap tendangan mae geri sebesar 14,60% pada atlet karate putri bintang jaya mandiri Tanjung Bintang. Kecepatan Reaksi memberikan komtribusi terhadap tendangan mae geri sebesar 18,7% pada atlet karate putri bintang jaya mandiri Tanjung Bintang.ABSTRACTThis study aims to find out the contribution between power limbs to the results of the mae geri kick on the independent jaya star athlete Tanjung Bintang. The type of research used is descriptive correlational with a sample of 30 female athletes. data collection techniques using tests and measurements. The results of the study and analysis showed that the average results of the measurement of female athlete's limb strength were 2.19, reaction speed of 59.73, the ability to shoot the mae geri 0.267. The results of the study concluded that the limb power contributed to the mae geri kick of 14.60% in female karate athletes in the independent Jaya star Tanjung Bintang. Reaction Speed gives contribution to mae geri kicks in the amount of 18.7% in female karate athletes independent jaya star Tanjung Bintang.Keywords: karate, contribution of leg power, speed of reaction, mae geri kicks
O CONTROLE DE CONVENCIONALIDADE COMO MECANISMO DE PROTEÇÃO DE DIREITOS HUMANOS DE ÍNDOLE POLÍTICA
CONVENTIONALITY CONTROL AS A POLITICAL HUMAN RIGHTS’S PROTECTION MECHANISM
Authors: Alvim Frederico Franco , Mariano Filho Jair José
Published: July 2019

A doutrina brasileira destaca especificamente a existência de duas técnicas processuais idôneas à proteção e à aplicação de normas de direitos humanos estabelecidas em documentos jurídicos internacionais, classificando-as em instrumentos internos e externos. O presente artigo tem como escopo apresentar um instrumento interno específico de proteção dos direitos humanos oriundos de tratados internacional: o denominado de controle de convencionalidade. Os direitos políticos consistem em elementos indissociáveis da visão moderna de democracia, uma vez que o Estado constitucional não se perfaz sem a outorga indiscriminada de prerrogativas necessárias ao exercício do talante participativo. A rigor, a categoria em análise compõe o próprio cerne do edifício democrático, na medida em que esse é pavimentado com a legitimidade dos que governam e com o controle dos que são governados. Por essas razões, os direitos políticos recebem especial proteção jurídica tanto no plano interno como na ordem supraestatal. Sendo, assim, reconhecidas como integrantes do importante leque que envolve os direitos fundamentais e humanos, as prerrogativas políticas, acaso violadas, ensejam em tese a invocação de instrumentos processuais próprios da normativa afeta ao Direito Internacional, em especial a técnica do controle de convencionalidade.
Approximation Algorithms for Complex-Valued Ising Models on Bounded Degree Graphs
Authors: Mann Ryan L. , Bremner Michael J.
Published: July 2019

We study the problem of approximating the Ising model partition function with complex parameters on bounded degree graphs. We establish a deterministic polynomial-time approximation scheme for the partition function when the interactions and external fields are absolutely bounded close to zero. Furthermore, we prove that for this class of Ising models the partition function does not vanish. Our algorithm is based on an approach due to Barvinok for approximating evaluations of a polynomial based on the location of the complex zeros and a technique due to Patel and Regts for efficiently computing the leading coefficients of graph polynomials on bounded degree graphs. Finally, we show how our algorithm can be extended to approximate certain output probability amplitudes of quantum circuits.
Electronic Signature Under the eIDAS Regulation in Domestic and Cross-Border Communication: Estonian Example
Authors: Kull Irene , Kask Laura
Published: July 2019

The aim of the article is to analyse issue of cross-border recognition and harmonized rules of electronic signatures under the eIDAS Regulation, which is intended to enable cross border electronic transactions. The authors reveal whether the legal order of the Estonia reflects the changes that have occurred in the field of electronic signatures since eIDAS Regulation. This article examines the legal consequences of a new distinction between the levels of electronic signature in the legal order of a Member State in private transactions and administrative procedures and the conditions under which cross-border recognition of electronic signatures in the European Union takes place.
Enfermedad de Ménétrier, reporte de caso (con video)
Authors: Gómez Zuleta Martín Alonso , Ruíz Morales Oscar Fernando , Riveros Javier
Published: July 2019

La enfermedad de Ménétrier, también conocida como gastritis hipertrófica gigante o gastropatía hipertrófica hipoproteinémica, es una entidad poco frecuente, caracterizada por una gastroenteropatía perdedora de proteínas, hipoclorhidria y engrosamiento de los pliegues mucosos del fondo y el cuerpo gástrico; es causante de un grupo clásico de síntomas que incluyen náuseas, vómitos, dolor abdominal y edema periférico; se asocia con un mayor riesgo de cáncer gástrico, sin embargo, su fisiopatología aún no está del todo esclarecida y su diagnóstico, clínico y endoscópico, puede llegar a ser difícil de establecer, por lo que se describe un caso clínico y se presenta una revisión sucinta de la literatura.
Tweetez-Vous Francais?
Authors: Bell Caragh , Cahill Kevin
Published: July 2019

We are living in the information age; our teaching and learning must adapt to this shift (Rosen, 2010). There are over 100 million active users posting over 500 million tweets a day which validates Twitter as an authentic and worthwhile place for literacy development. Twitter offers an educator the opportunity to connect a class to the outside world; it connects the students themselves to a diverse community outside the microcosm of the classroom. This study looks at students’ thoughts on the use of social media – namely Twitter – to enhance the learning of a second language in a post-primary French classroom in Ireland. A controlled group of fifth years students took part in the study. They submitted reflective diaries via email and interviews were conducted and recorded. The results of this study suggests that the use of Twitter in language teaching has a future, but has to be implemented properly and gradually.
Study of fattening and slaughter traits of cattle under the influence of flax seed based nutrition
Authors: Petricevic Maja , Zivkovic Dusan , Andric Ostojic , Niksic Dragan , Petricevic Veselin , Gogic Marija , Mandic Violeta
Published: July 2019

The trial was designed in order to examine the impact of flax seed in the
nutrition of young cattle/bulls, in the final stage of the fattening. In the
trial, 30 bulls of Simmental breed of uniform initial weight were selected,
divided into 2 groups (control and experimental). The control animal group
did not consume flax seed as a food supplement. Cattle of the experimental
group consumed flax seed in an amount of 3.75% (300 g per day) of
concentrated meal in the last 90 days of fattening, i.e. 300 g per day. The
study included the examination of the fattening performance, slaughter
traits and the composition of the bovine carcass. After slaughtering, warm
carcass sides, with and without kidneys, were measured individually.
Subsequent to period of cooling, the left carcass side it was cut into the
main carcass parts according to the Rulebook. The results of the study
showed that the addition of flax seed in the diet did not have a
statistically significant effect on the body weight of bulls at the end of
the trial. It was found that the addition of flax seed in the feed during
the final stage of fattening did not have an impact on the differences in
the average overall gain of bulls and the feed conversion ratio. Based on
the data obtained by cutting of carcass sides to main parts, it was
established that feeding with flax seeds had no significant effect on the
share of carcass parts.
Damage trends in selected forest regions and a future period forecast
Authors: Rankovic Nenad , Stanisic Mirjana , Nedeljkovic Jelena , Nonic Dragan
Published: July 2019

The research carried out in Serbia so far revealed an increase in forest
damages from natural hazards, as well as increased share in total forest
damages with their territorial inequality. This research aims to determine
the trend in the number and area of damages, the area of damages per one
harmful event, and the prognosis of damages caused by the harmful effects of
water, wind and fire in selected forest regions of Serbia. A modelling method
was used as a basic scientific method, with an application of trend
regression and correlation analysis and other specific methods. The results of
the research indicate that there are differences in the trends per harmful
factor. An increasing trend is visible with the damages caused by the effects
of water and wind but also in the extent of damages caused by all three
detrimental factors. A decreasing trend is noticeable only for the damages
caused by fire.
Diabetes Increases Risk of Gastric Cancer After Helicobacter pylori Eradication: A Territory-Wide Study With Propensity Score Analysis
Authors: Cheung Ka Shing , Chan Esther W. , Chen Lijia , Seto Wai Kay , Wong Ian C.K. , Leung Wai K.
Published: July 2019

OBJECTIVE

Whether diabetes mellitus (DM) increases risk of gastric cancer (GC) remains controversial because of inadequate adjustments for important risk factors, including Helicobacter pylori (HP) infection status, concomitant medication use, and cancer site. We investigated whether type 2 DM increased risk of GC in patients after they received treatment for HP infection.

RESEARCH DESIGN AND METHODS

This was a territory-wide cohort study of patients aged ≥45 years who had received clarithromycin-based triple therapy for HP infection between 2003 and 2012 in Hong Kong. Data were retrieved from a public electronic health database. Observation started from receipt of therapy for HP infection to GC diagnosis, death, or the end of the study (December 2015). Exclusion criteria included type 1 DM, GC diagnosed within the 1st year of HP therapy, prior GC or gastrectomy, and retreatment for HP infection. The adjusted hazard ratio (aHR) of GC with type 2 DM was calculated by using a Cox model that adjusted for 20 covariates (age, sex, comorbidities, and medications) through propensity score regression.

RESULTS

During a median follow-up of 7.1 years (interquartile range 4.8–9.3 years), 153 of 46,460 patients (0.33%) developed GC at a median age of 72.4 years. Type 2 DM was associated with an increased risk of GC (aHR 1.73 [95% CI 1.08–2.79]). Stratified analysis showed an increase in risk for cardia cancer only (aHR 3.40 [95% CI 1.45–7.97]) and in those with suboptimal DM control (time-weighted mean HbA1c ≥6.0% [42 mmol/mol]; aHR 1.68 [95% CI 1.07–2.63]).

CONCLUSIONS

Type 2 DM is associated with an increased risk of GC among patients in whom HP was eradicated, in particular gastric cardia cancer and in those with suboptimal DM control.