bluuebunny/crossref_metadata_2025 huggingface dataset:
Risk of Benign and Malignant Thyroid Disorders in Subjects Treated for Paediatric/Adolescent Neoplasia: Role of Morphological and Functional Screening
Authors: Sapuppo Giulia , Tavarelli Martina , Cannata Emanuela , La Spina Milena , Russo Marco , Scollo Claudia , Spadaro Angela , Masucci Romilda , Lo Nigro Luca , Russo Giovanna , Di Cataldo Andrea , Pellegriti Gabriella
Published: September 2021

Background: Patients treated for paediatric/adolescent (P/A) neoplasia have a high incidence of both benign and malignant thyroid diseases. Given the high incidence of sequelae, literature data show a clinical benefit of morpho-functional thyroid screening in paediatric/adolescent cancer survivors and a careful lifetime follow-up. Patients and methods: The incidence of thyroid alterations was evaluated in a consecutive series of 343 patients treated with chemotherapy (CHE) and radiotherapy (RTE) or only with CHE for P/A tumours between 1976 and 2018 (mean age at time of primary paediatric malignancy 7.8 ± 4.7 years). All patients underwent thyroidal morpho-functional evaluation between 2000 and 2019. Results: 178 patients (51.9%) were treated only with CHE and 165 (48.1%) with CHE+RTE. A functional and/or structural thyroid disease was diagnosed in 147 (42.5%; 24.2% in CHE and 62.4% in CHE+RTE group; p = 0.0001). Of note, 71 (20.7%) patients with no evidence of disease at first evaluation developed a thyroid alteration during the follow-up. Primitive hypothyroidism was diagnosed in 54 patients (15.7%; 11.2% in CHE vs. 20.6% in CHE+RTE group; p = 0.01) and hyperthyroidism in 4. Sixty-three patients developed thyroid nodules (18.4%; 4.0% in CHE and 14.1% in CHE+RTE group; p < 0.001); thyroid cancer was diagnosed in 30 patients (8.7%; 4.5% in CHE and 12.4% in CHE + RTE group; p = 0.007). Conclusions: In patients treated with CHE+RTE, the prevalence of hypothyroidism and nodular pathology, both malignant and benign, were significantly greater than in patients treated with CHE. However, also in the CHE group, the frequency of thyroid disease is not negligible and the pathogenetic mechanisms remain to be clarified. Our data suggest the clinical benefit of morpho-functional thyroid screening in P/A cancer survivors.
Maternal Age, the Disparity across Regions and Their Correlation to Sudden Infant Death Syndrome in Taiwan: A Nationwide Cohort Study
Authors: Huang Lin-Yi , Chen Wan-Ju , Yang Yung-Ning , Wu Chien-Yi , Wu Pei-Ling , Tey Shu-Leei , Yang San-Nan , Liu Hsien-Kuan
Published: September 2021

Sudden infant death syndrome (SIDS) has always been a regrettable issue for families. After sleeping in the supine position was proposed, the incidence of SIDS declined dramatically worldwide. However, SIDS still accounts for the top 10 causes of infant deaths in Taiwan. Recognizing the risk factors and attempting to minimize these cases are imperative. We obtained information on cases with SIDS from the National Health Insurance Research Database in Taiwan and interconnected it with the Taiwan Maternal and Child Health Database to acquire infant–maternal basal characteristics between 2004 and 2017. The SIDS subjects were matched 1:10 considering gestational age to normal infants. After case selection, a total of 953 SIDS cases were included. Compared with healthy infants, SIDS infants had younger parents, lower birth weight, and lower Apgar scores. After adjusting for potential confounders, infants with mothers aged <20 years had 2.81 times higher risk of SIDS. Moreover, infants in the non-eastern region had a significantly lower risk of SIDS than those in the eastern region. We concluded that infants of young mothers (especially maternal age <20 years) and infants in the eastern region of Taiwan had a higher risk of SIDS than their counterparts.
The Potential of Sky Fruit as an Anti-Aging and Wound Healing Cosmeceutical Agent
Authors: Mahendra Camille Keisha , Tan Loh Teng Hern , Mahendra Cayvern Kishen , Ser Hooi-Leng , Pusparajah Priyia , Htar Thet Thet , Chuah Lay-Hong , Yap Wei Hsum , Tang Siah Ying , Ming Long Chiau , Yow Yoon-Yen , Goh Bey Hing
Published: September 2021

There are many extrinsic factors that can contribute to the premature aging of the skin. In recent years, the demand for natural cosmetic from the general population has noticeable grow. Therefore, this research aimed to investigate the bioproperties of sky fruit (Swietenia macrophylla) seed extract that could help to inhibit premature skin aging. Firstly, the extract and its fractions were tested on HaCaT cells for their wound healing properties. The presence of sky fruit’s extract and its fractions on scratch wound significantly improved cellular proliferation, migration, and closure of the wound. These effects were distinctly observed following the treatment with S. macrophylla hexane fraction (SMHF) and S. macrophylla water fraction (SMWF). Our continuous research study revealed that SMWF had antioxidant properties, which might be one of the factors contributing to its emerging wound healing properties because antioxidants are known to act as suppressors of the inflammatory pathway and aid the transition towards cell proliferation. In addition, all samples had critical wavelengths that indicated that they were able to absorb the whole UVB range and some parts of the UVA wavelength. This suggested that S. macrophylla might contain potential photoprotective bioactive compounds, which could be developed into anti-UVB photoprotective sunscreens. Thus, this warrants further studies focusing on isolation and identifications of the bioactive compounds responsible for both its photoprotective and wound healing properties. A deeper study on mechanisms of the pathways that were affected by these compounds should be conducted as well to better understand this natural product and develop it into a potential cosmeceutical ingredient.
Stabilization of Haloalkane Dehalogenase Structure by Interfacial Interaction with Ionic Liquids
Authors: Shaposhnikova Anastasiia , Kuty Michal , Chaloupkova Radka , Damborsky Jiri , Kuta Smatanova Ivana , Minofar Babak , Prudnikova Tatyana
Published: September 2021

Ionic liquids attracted interest as green alternatives to replace conventional organic solvents in protein stability studies. They can play an important role in the stabilization of enzymes such as haloalkane dehalogenases that are used for biodegradation of warfare agents and halogenated environmental pollutants. Three-dimensional crystals of haloalkane dehalogenase variant DhaA80 (T148L+G171Q+A172V+C176F) from Rhodococcus rhodochrous NCIMB 13064 were grown and soaked with the solutions of 2-hydroxyethylammonium acetate and 1-butyl-3-methylimidazolium methyl sulfate. The objective was to study the structural basis of the interactions between the ionic liquids and the protein. The diffraction data were collected for the 1.25 Å resolution for 2-hydroxyethylammonium acetate and 1.75 Å resolution for 1-butyl-3-methylimidazolium methyl sulfate. The structures were used for molecular dynamics simulations to study the interactions of DhaA80 with the ionic liquids. The findings provide coherent evidence that ionic liquids strengthen both the secondary and tertiary protein structure due to extensive hydrogen bond interactions.
Artificial Intelligence in Dermatopathology: New Insights and Perspectives
Authors: Cazzato Gerardo , Colagrande Anna , Cimmino Antonietta , Arezzo Francesca , Loizzi Vera , Caporusso Concetta , Marangio Marco , Foti Caterina , Romita Paolo , Lospalluti Lucia , Mazzotta Francesco , Cicco Sebastiano , Cormio Gennaro , Lettini Teresa , Resta Leonardo , Vacca Angelo , Ingravallo Giuseppe
Published: September 2021

In recent years, an increasing enthusiasm has been observed towards artificial intelligence and machine learning, involving different areas of medicine. Among these, although still in the embryonic stage, the dermatopathological field has also been partially involved, with the attempt to develop and train algorithms that could assist the pathologist in the differential diagnosis of complex melanocytic lesions. In this article, we face this new challenge of the modern era, carry out a review of the literature regarding the state of the art and try to determine promising future perspectives.
Skin Adverse Reactions to Novel Messenger RNA Coronavirus Vaccination: A Case Series
Authors: Peigottu Maria Francesca , Ferreli Caterina , Atzori Maria Giovanna , Atzori Laura
Published: September 2021

Vaccines are actually the most effective strategy to control the COVID-19 spread and reduce mortality, but adverse reactions can occur. Skin involvement with novel messenger RNA coronavirus vaccines seems frequent but is not completely characterized. A real-world experience in the recent vaccination campaign among health care workers in Sardinia (Italy) is reported. In over a total of 1577 persons vaccinated, 9 cases of skin adverse reactions were observed (0.5%). All reactions have been reported to the Italian Pharmacovigilance Authority. Eight occurred in women (mean age 46 years), and five were physicians and four nurses. All patients had a significant allergology history but not for the known vaccine excipients. After dose one, no injection site reactions were observed, but widespread pruritus (n = 3), mild facial erythema (n = 1), and maculopapular rash (n = 3) occurred in the following 24–48 h in three patients. These three patients were excluded from the second dose. Of the remaining six patients, one developed mild anaphylaxis within the observation period at the vaccination hub and five delayed facial erythematous edema and maculopapular lesions, requiring antihistamines and short-course corticosteroid treatment. Spontaneous reporting is paramount to adjourning vaccination guidance and preventive measures in order to contribute to the development of a safe vaccine strategy. Dermatologist’ expertise might provide better characterization, treatment, and screening of individuals at high risk of skin adverse reactions.
Prais–Winsten Algorithm for Regression with Second or Higher Order Autoregressive Errors
Authors: Vougas Dimitrios V.
Published: September 2021

There is no available Prais–Winsten algorithm for regression with AR(2) or higher order errors, and the one with AR(1) errors is not fully justified or is implemented incorrectly (thus being inefficient). This paper addresses both issues, providing an accurate, computationally fast, and inexpensive generic zig-zag algorithm.
Entrepreneurial Economies
Authors: Holcombe Randall G.
Published: September 2021

The study of entrepreneurship often focuses on the activities of the entrepreneur. While entrepreneurship is undertaken by individuals, the degree to which individuals are entrepreneurial, and the directions in which their entrepreneurial actions take, are the result of the institutional environment. Some economies are more entrepreneurial than others. After discussing the institutional factors that encourage entrepreneurship, the ways in which economic models depict the economy are discussed, pointing toward the different policy conclusions regarding entrepreneurship that emanate from different assumptions in economic conditions.
In Vitro Screening of Plant Materials to Reduce Ruminal Protozoal Population and Mitigate Ammonia and Methane Emissions
Authors: Khejornsart Pichad , Cherdthong Anusorn , Wanapat Metha
Published: September 2021

Alternative feed sources can be utilized to reduce enteric methane (CH4) emissions, a major greenhouse gas that contributes to global warming. This study aimed to evaluate the potential use of tropical plants to improve digestibility, reduce protozoal populations, improve rumen fermentation, and minimize methane emissions from ruminants. The plants considered herein grow in tropical climates, are easily accessible in large quantities, and are directly related to human food production. Nine plants that grow naturally in tropical climates were assessed. Plant supplementation substantially enhanced accumulative gas production at 24 h (p < 0.05). The apparent organic matter digestibility (AOMDvt) of the diet was not affected by five of the nine plants. With the addition of the plant material, ammonia nitrogen concentrations were reduced by up to 47% and methane concentrations were reduced by 54%. Five of the nine plant materials reduced methane production in terms of CH4/dry matter and CH4/digestibility of the organic matter by 15–35% and 8–24%, respectively. In conclusion, supplementation with plants with high tannin contents was shown to be a viable strategy for improving rumen fermentation, reducing protozoal populations, and limiting methane emissions. In this regard, the leaves of Piper sarmentosum, Acmella oleracea, Careya arborea, and Anacardium occidentale were especially promising.
Development of an Araucaria araucana Beer-like Beverage: Process and Product
Authors: Durán Angélica , Reyes-De-Corcuera José , Garay Gustavo , Valencia Pedro , Urtubia Alejandra
Published: September 2021

The seed from the Araucaria araucana (in Spanish, piñon) tree, native to Chile and Argentina, is sold mainly as raw seed. Engineering a process to add value to piñon has the potential to positively impact local indigenous communities with very little ecological impact because it is routinely harvested in the wild. This study evaluated the feasibility of using 100% piñon, or as a blend with barley malt, to produce a beer-like beverage, while also evaluating consumer acceptance of the beverage’s piñon characteristics. Prototypes generated based on 93% piñon and 7% oat (enzymatic treatment of α-amylase, glucoamylase, protease and β-glucanase), as well as 50% piñon and 50% barley (no external enzymatic treatment), were evaluated. Overall acceptability by a consumer acceptance panel (21 consumers) rated the 100% piñon and the piñon–barley malt blend 5/9 and 7/9, respectively. The piñon–barley malt blend prototype stood out for its low level of carbohydrates, high potassium content and banana and clove aromas.
Two-Stage Anaerobic Codigestion of Crude Glycerol and Micro-Algal Biomass for Biohydrogen and Methane Production by Anaerobic Sludge Consortium
Authors: Sittijunda Sureewan , Sitthikitpanya Napapat , Plangklang Pensri , Reungsang Alissara
Published: September 2021

Optimization of factors affecting biohydrogen production from the codigestion of crude glycerol and microalgal biomass by anaerobic sludge consortium was conducted. The experiments were designed by a response surface methodology with central composite design. The factors affecting the production of hydrogen were the concentrations of crude glycerol, microalgal biomass, and inoculum. The maximum hydrogen production (655.1 mL-H2/L) was achieved with 13.83 g/L crude glycerol, 23.1 g-VS/L microalgal biomass, and 10.3% (v/v) inoculum. The hydrogenic effluents obtained under low, high, and optimal conditions were further used as substrates for methane production. Methane production rates and methane yield of 868.7 mL-CH4/L and 2.95 mL-CH4/L-h were attained with the effluent produced under optimum conditions. The use of crude glycerol and microalgal biomass as cosubstrates had an antagonistic effect on biohydrogen production and a synergistic effect on methane fermentation. The two-stage process provided a more attractive solution, with a total energy of 1.27 kJ/g-VSadded, than the one-stage process.
Network Theory and Switching Behaviors: A User Guide for Analyzing Electronic Records Databases
Authors: Gronchi Giorgio , Raglianti Marco , Giovannelli Fabio
Published: September 2021

As part of studies that employ health electronic records databases, this paper advocates the employment of graph theory for investigating drug-switching behaviors. Unlike the shared approach in this field (comparing groups that have switched with control groups), network theory can provide information about actual switching behavior patterns. After a brief and simple introduction to fundamental concepts of network theory, here we present (i) a Python script to obtain an adjacency matrix from a records database and (ii) an illustrative example of the application of network theory basic concepts to investigate drug-switching behaviors. Further potentialities of network theory (weighted matrices and the use of clustering algorithms), along with the generalization of these methods to other kinds of switching behaviors beyond drug switching, are discussed.
2D Hydrodynamics of a Plate: From Creeping Flow to Transient Vortex Regimes
Authors: Chashechkin Yuli D. , Zagumennyi Iaroslav V.
Published: September 2021

Based on the numerical and experimental visualization methods, the flow patterns around a uniformly moving plate located at an arbitrary angle of attack are studied. The study is based on the fundamental equations of continuity, momentum and stratifying substance transport for the cases of strong and weak stratified fluids, as well as potential and actually homogeneous ones. The visualization technique and computation codes were compiled bearing in mind conditions of internal waves, vortices, upstream, and downstream wakes registration, as well as the resolution of ligaments in the form of thin interfaces in schlieren flow images. The analysis was carried out in a unified mathematical formulation for a wide range of plate motion parameters, including slow diffusion-induced flows and fast transient vortex flows. The patterns of formation and subsequent evolution of the basic structural components, such as upstream disturbances, downstream wake, internal waves, vortices, and ligaments, are described both at start of motion and subsequent uniform movement of the plate. Calculations of forces acting on the obstacle in the flow were carried out to study effects of variations in fluid properties, flow conditions and plate parameters on the dynamic characteristics of the obstacle. The numerical and experimental results on the flow patterns around a plate are in a good agreement with each other for different flow regimes.
Modeling and Forecasting Daily Hotel Demand: A Comparison Based on SARIMAX, Neural Networks, and GARCH Models
Authors: Ampountolas Apostolos
Published: September 2021

Overnight forecasting is a crucial challenge for revenue managers because of the uncertainty associated between demand and supply. However, there is limited research that focuses on predicting daily hotel demand. Hence, this paper evaluates various models’ of traditional time series forecasting performances for daily demand at multiple horizons. The models include the seasonal naïve, Holt–Winters (HW) triple exponential smoothing, an autoregressive integrated moving average (ARIMA), a seasonal autoregressive integrated moving average (SARIMAX) with exogenous variables, multilayer perceptron (MLP) artificial neural networks model (ANNs), an sGARCH, and GJR-GARCH models. The dataset of this study contains daily demand observations from a hotel in a US metropolitan city from 2015 to 2019 and a set of exogenous social and environmental features such as temperature, holidays, and hotel competitive set ranking. Experimental results indicated that under the MAPE accuracy measure: (i) the SARIMAX model with external regressors outperformed the ANN-MLP model with similar external regressors and the other models, in every one horizon except one out of seven forecast horizons; (ii) the sGARCH(4, 2) and GJR-GARCH(4, 2) shows a superior predictive accuracy at all horizons. The results performance is evaluated by conducting pairwise comparisons between the different model’s distribution of forecasts using Diebold–Mariano and Harvey–Leybourne–Newbold tests. The results are significant for revenue managers because they provide valuable insights into the exogenous variables that impact accurate daily demand forecasting.
Dissolved Organic Matter in the Global Ocean: A Primer
Authors: Hansell Dennis A. , Orellana Mónica V.
Published: September 2021

Marine dissolved organic matter (DOM) holds ~660 billion metric tons of carbon, making it one of Earth’s major carbon reservoirs that is exchangeable with the atmosphere on annual to millennial time scales. The global ocean scale dynamics of the pool have become better illuminated over the past few decades, and those are very briefly described here. What is still far from understood is the dynamical control on this pool at the molecular level; in the case of this Special Issue, the role of microgels is poorly known. This manuscript provides the global context of a large pool of marine DOM upon which those missing insights can be built.
Molecular Simulation and Theoretical Analysis of Slide-Ring Gels under Biaxial Deformation
Authors: Tanahashi Kotaro , Koga Tsuyoshi
Published: September 2021

Slide-ring (SR) gels, a new type of gels that have cross-links moving along the chains, are known to have unique mechanical characteristics. In the case of biaxial deformations, it has been experimentally shown that the stress–strain (S–S) relationships of SR gels can be well described by the neo-Hookean (NH) model. This behavior is quite different from that of conventional chemical gels, where the S–S curves deviate from the NH model. To understand the molecular mechanism of such peculiar elastic properties of SR gels, we studied the effects of movable cross-links by using molecular simulations and theoretical analysis. We calculate the S–S relationships in biaxial deformation for two types of models: slip model, where the cross-links can slide along chains representing SR gels, and non-slip model, which corresponds to conventional chemical gels. In the theoretical analysis, we calculate the S–S relationships by using the models with the Gaussian and the Langevin chains to investigate the nonlinear stretching effect of the chain in the slip and non-slip models. As a result, we found that the peculiar elastic behaviors of SR gels in biaxial deformations are well explained by the effect of movable cross-links suppressing the nonlinear stretching of the chain.
Gel-Based Materials for Ophthalmic Drug Delivery
Authors: Cassano Roberta , Di Gioia Maria Luisa , Trombino Sonia
Published: September 2021

The most common route of administration of ophthalmic drugs is the topical route because it is convenient, non-invasive, and accessible to all patients. Unfortunately, drugs administered topically are not able to reach effective concentrations. Moreover, their bioavailability must be improved to decrease the frequency of administrations and their side effects, and to increase their therapeutic efficiency. For this purpose, in recent decades, particular attention has been given to the possibility of developing prolonged-release forms that are able to increase the precorneal residence time and decrease the loss of the drug due to tearing. Among these forms, gel-based materials have been studied as an ideal delivery system because they are an extremely versatile class with numerous prospective applications in ophthalmology. These materials are used in gel eye drops, in situ gelling formulations, intravitreal injections, and therapeutic contact lenses. This review is intended to describe gel-based materials and their main applications in ophthalmology.
Parochial Linguistic Education: Patterns of an Enduring Friction within a Divided Catalonia
Authors: Oller Josep Maria , Satorra Albert , Tobeña Adolf
Published: September 2021

Amid the tensions created by the secession push in Catalonia (Spain), an important conflicting issue has been the “immersion linguistic educational system”, in which the Catalan language has precedence throughout all of the primary and secondary school curricula. Here, we present an analysis of a survey (n = 1002) addressing features of linguistic and political opinion profiles with reference to the mother language and feelings of national identity. The results show that the mother language is a factor that differentiated the participants in terms of common linguistic uses and opinions about the “immersion educational system”. These results were confirmed when segmenting respondents via their feelings of national self-identification. The most distinctive political opinions consisted of either asserting or denying the damage to social harmony produced by the secession campaign. Overall, the findings show that a major fraction of the Catalonian citizenry is subjected to an education system that does not meet their linguistic preferences. We discuss these findings, connecting them to an ethnolinguistic divide based mainly on mother language (Catalan vs. Spanish) and family origin—a complex frontier that has become the main factor determining alignment during the ongoing political conflict.
Settler Colonial Structures of Domestication: British Home Children in Canada
Authors: Johnson Morgan Brie
Published: September 2021

There has been a surge of research on Home Children in the past several decades, as the phenomenon previously unknown to many came into the spotlight. However, much of the historical research has focused on either the psychological and physical impacts on the children at the hands of their new “families” (there were many reports of child abuse and neglect) or the ways they were saved from their poverty in Britain by being sent to the colonies. This article will put this existing historical research into conversation with theories of settler colonialism, considering Home Children as a tool of domestication for the social reproduction of Canadian white settler society, which was paired with the forced removal of Indigenous peoples from their lands. This analysis stems from and is intertwined with personal reflections on my own family history as a white settler woman descending from a Home Child to explore the gendered labour of social reproduction as a crucial pillar in creating and maintaining settler colonial Canada. Following Lorenzo Veracini’s argument that settler colonialism is a distinct structure that uses domestication as one of its key tenets and relies on its “regenerative capacity”, this paper will explore how British Home Children were a key component of settler colonialism in Canada and how this history has manifested in the current gendered, racialized, and classed politics of “settling”.
Unraveling the Modulation of Controlled Salinity Stress on Morphometric Traits, Mineral Profile, and Bioactive Metabolome Equilibrium in Hydroponic Basil
Authors: Corrado Giandomenico , Vitaglione Paola , Chiaiese Pasquale , Rouphael Youssef
Published: September 2021

Salinity is a major concern in several ecosystems and has a significant impact on global agriculture. To increase the sustainability of horticultural food systems, better management and usage of saline water and soils need to be supported by knowledge of the crop-specific responses to tolerable levels of salinity. The aim of this work was to study the effects of mild salinity on morphological growth and development, leaf color, mineral composition, antioxidant activities, and phenolic profile of sweet basil (Ocimum basilicum L.). Plants grew in hydroponics and were exposed to three nutrient solutions (NSs) differing in the NaCl concentration (either 0, 20, or 40 mM). Inhibitory effects on leaf area, fresh yield, and shoot biomass were evident starting from the lowest NaCl concentration, and they became more severe and wide-ranging at 40 mM, also affecting height and root-to-shoot ratio. Salinity increased the nutritional quality in terms of antioxidant activity and polyphenols in leaves, with a reduction in macroelements at 40 mM NaCl. Moreover, the two mild NaCl concentrations specifically modified the concentration of various phenolic acids in leaves. Overall, the use of a slightly saline (20 mM) NS could be tolerated by basil in hydroponics, strongly ameliorating the nutritional profile in the face of relative yield loss. Considering the significantly higher accumulation of bioactive compounds, our work implies that the use of low-salinity water can sustainably increase the nutritional value and the health-promoting features of basil leaves.
Fatty Acid Profile, Tocopherol Content of Seed Oil, and Nutritional Analysis of Seed Cake of Wood Apple (Limonia acidissima L.), an Underutilized Fruit-Yielding Tree Species
Authors: Lamani Shrinivas , Anu-Appaiah Konerira Aiyappa , Murthy Hosakatte Niranjana , Dewir Yaser Hassan , Rihan Hail Z.
Published: September 2021

The present study was aimed at analyzing the fatty acid composition, tocopherols, and physico-chemical characterization of wood apple (Limonia acidissima L.) seed oil and the nutritional profile of seed cake. The fatty acids in seed oil were analyzed by gas chromatography–mass spectrometry (GC-MS), and the total seed oil was 32.02 ± 0.08%, comprising oleic (21.56 ± 0.57%), alpha-linolenic (16.28 ± 0.29%), and linoleic acid (10.02 ± 0.43%), whereas saturated fatty acid content was 33.38 ± 0.60% including palmitic (17.68 ± 0.65%) and stearic acid (14.15 ± 0.27%). A greater amount of unsaturated fatty acids (52.37%) were noticed compared to saturated fatty acids (33.38%); hence the seed is highly suitable for nutritional and industrial applications. Gamma-tocopherol was present in a higher quantity (39.27 ± 0.07 mg/100 g) as compared to alpha (12.64 ± 0.01 mg/100 g) and delta (3.77 ± 0.00 mg/100 g) tocopherols, which are considered as natural antioxidants. The spectrophotometric technique was used for quantitative analysis of total phenolic content, and it revealed 135.42 ± 1.47 mg gallic acid equivalent /100 g DW in seed cake. All the results of the studied seed oil and cake showed a good source of natural functional ingredients for several health benefits.
Variables Associated with Coronavirus Disease 2019 Vaccine Hesitancy Amongst Patients with Neurological Disorders
Authors: Ghaffari-Rafi Arash , Teehera Kimberly , Higashihara Tate , Morden Frances , Goo Connor , Pang Michelle , Sutton Cori , Kim Kyung , Lew Rachel , Luu Kayti , Yamashita Shaina , Mitchell Catherine , Carrazana Enrique , Viereck Jason , Liow Kore
Published: September 2021

Introduction: Given that the success of vaccines against coronavirus disease 2019 (COVID-19) relies on herd immunity, identifying patients at risk for vaccine hesitancy is imperative—particularly for those at high risk for severe COVID-19 (i.e., minorities and patients with neurological disorders). Methods: Among patients from a large neuroscience institute in Hawaii, vaccine hesitancy was investigated in relation to over 30 sociodemographic variables and medical comorbidities, via a telephone quality improvement survey conducted between 23 January 2021 and 13 February 2021. Results: Vaccine willingness (n = 363) was 81.3%. Univariate analysis identified that the odds of vaccine acceptance reduced for patients who do not regard COVID-19 as a severe illness, are of younger age, have a lower Charlson Comorbidity Index, use illicit drugs, or carry Medicaid insurance. Multivariable logistic regression identified the best predictors of vaccine hesitancy to be: social media use to obtain COVID-19 information, concerns regarding vaccine safety, self-perception of a preexisting medical condition contraindicated with vaccination, not having received the annual influenza vaccine, having some high school education only, being a current smoker, and not having a prior cerebrovascular accident. Unique amongst males, a conservative political view strongly predicted vaccine hesitancy. Specifically for Asians, a higher body mass index, while for Native Hawaiians and other Pacific Islanders (NHPI), a positive depression screen, both reduced the odds of vaccine acceptance. Conclusion: Upon identifying the variables associated with vaccine hesitancy amongst patients with neurological disorders, our clinic is now able to efficiently provide ancillary COVID-19 education to sub-populations at risk for vaccine hesitancy. While our results may be limited to the sub-population of patients with neurological disorders, the findings nonetheless provide valuable insight to understanding vaccine hesitancy.
Uncertainty in Building Inspection and Diagnosis: A Probabilistic Model Quantification
Authors: Pereira Clara , Silva Ana , Ferreira Cláudia , de Brito Jorge , Flores-Colen Inês , Silvestre José D.
Published: September 2021

In the field of building inspection and diagnosis, uncertainty is common and surveyors are aware of it, although it is not easily measured. This research proposes a model to quantify uncertainty based on the inspection of rendered façades. A Bayesian network is developed, considering three levels of variables: characteristics of the building, façade and exposure conditions; causes of defects; and defects. To compute conditional probabilities, the results of an inspection campaign from the literature are used. Then, the proposed model is validated and verified using inspection results from another sample, the combination of a strength-of-influence diagram and sensitivity analysis and the application of the model to a case study. Results show that the probabilities computed by the model are a reasonable representation of the hesitancy in decision making during the diagnosis process based only on visual observation. For instance, design and execution errors show lower probabilities due to not being verifiable a posteriori without detailed documentation. The proposed model may be extended and replicated for other building materials in the future, as it may be a useful tool to improve the perception of uncertainty in a key stage of building maintenance or rehabilitation.
Can the Addition of NT-proBNP and Glucose Measurements Improve the Prognostication of High-Sensitivity Cardiac Troponin Measurements for Patients with Suspected Acute Coronary Syndrome?
Authors: Kavsak Peter A. , Mondoux Shawn E. , Hewitt Mark K. , Ainsworth Craig , Hill Stephen , Worster Andrew
Published: September 2021

Guidelines published in 2021 have supported natriuretic peptide (NP) testing for the prognostication in patients with acute coronary syndrome (ACS) and for the diagnosis of chronic and acute heart failure (HF). Our objective was to determine if the addition of N-terminal pro B-type NP (NT-proBNP) and glucose to high-sensitivity cardiac troponin (hs-cTn) could better identify emergency department (ED) patients with potential ACS at low- and high-risk for a serious cardiovascular outcome over the next 72 h. The presentation sample in two different ED cohorts which enrolled patients with symptoms suggestive of ACS within six hours of pain onset (Cohort-1, n = 126 and Cohort-2, n = 143) that had Abbott hs-cTnI, Roche hs-cTnT, NT-proBNP and glucose were evaluated for NT-proBNP alone and combined with hs-cTn and glucose for the primary outcome (composite which included death, myocardial infarction, HF, serious arrhythmia and refractory angina) via receiver-operating characteristic (ROC) curve analyses with area under the curve (AUC) and diagnostic estimates derived. The AUC for NT-proBNP for the primary outcome was 0.68 (95% confidence interval (CI): 0.59–0.76) and 0.75 (95%CI: 0.67–0.82) in Cohort-1 and 2, respectively, with the 125 ng/L cutoff yielding a higher sensitivity (≥75%) as compared to the 300 ng/L cutoff (≥58%). Using the 125 ng/L cutoff for NT-proBNP with the published glucose and hs-cTn cutoffs for risk-stratification produced a new score (GuIDER score for Glucose, Injury and Dysfunction in the Emergency-setting for cardiovascular-Risk) and yielded higher AUCs as compared to NT-proBNP (p < 0.05). GuIDER scores of 0 and 5 using either hs-cTnI/T yielded sensitivity estimates of 100% and specificity estimates > 92% for the primary outcome. A secondary analysis assessing MI alone in the overall population (combined Cohorts 1 and 2) also achieved 100% sensitivity for MI with a GuIDER cutoff ≥ 2, ruling-out 48% (Roche) and 38% (Abbott) of the population at presentation for MI. Additional studies are needed for the GuIDER score in both the acute and ambulatory setting to further refine the utility, however, the preliminary findings reported here may present a pathway forward for inclusion of NP testing for ruling-out serious cardiac events and MI in the emergency setting.
Green Ceramic Machining: Determination of the Recommended Feed Rate for Y-TZP Milling
Authors: Demarbaix Anthonin , Mulliez Marylou , Rivière-Lorphèvre Edouard , Spitaels Laurent , Duterte Charles , Preux Nicolas , Petit Fabrice , Ducobu François
Published: September 2021

Manufacturing of advanced ceramic parts exhibiting complex geometries is laborious and expensive. Traditionally, the machining is carried out on a so-called ‘green ceramic’: a compact composed of ceramic powder held with the help of a binder. This difficulty is due not only to the composition of the material, but also to the lack of methods that determine optimal machining parameters. The goal of this paper is to apply the method based on ductile material behavior to determine a feed rate working range to ensure a machining quality. Indeed, a previous study demonstrated the limits of this method in determining cutting speed. In this case, two material removal mechanisms are observed: a mechanism dominated by pulling of the material and a proper machining mechanism. This demonstrates that the specific cutting energy is a reliable indicator for machining quality assessment. In the studied case, the recommended machining parameters to ensure quality machining of Y-TZP green ceramic with a 3 mm diameter cylindrical tool are: a cutting speed of 250 m/min, a feed per tooth of 0.037 mm/tooth, an axial depth of cut of 0.7 mm, and a radial depth of cut of 3 mm.
Stretching for Recovery from Groin Pain or Injury in Athletes: A Critical and Systematic Review
Authors: Afonso José , Claudino João Gustavo , Fonseca Hélder , Moreira-Gonçalves Daniel , Ferreira Victor , Almeida José Marques , Clemente Filipe Manuel , Ramirez-Campillo Rodrigo
Published: September 2021

Stretching is usually used as part of rehabilitation protocols for groin pain or injury, but its specific contribution to and within multimodal recovery protocols is unclear. Our goal was to systematically review the effects of stretching for the recovery from groin pain or injury. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed, with eligibility criteria defined according to PICOS: (Participants) athletes with groin pain or injuries; (Interventions) interventions with stretching as the differentiating factor; (Comparators) comparators not applying stretching; (Outcomes) symptom remission or improvement and/or time to return to sport and/or return to play; (Study design) randomized controlled trials. Searches were performed on 26 March 2021, in CINAHL, Cochrane Library, EBSCO, EMBASE, PEDro, PubMed, Scielo, Scopus, SPORTDiscus, and Web of Science, with no limitations regarding language or date, and no filters. Of 117 retrieved results, 65 were duplicates and 49 were excluded at the screening stage. The three articles eligible for full-text analysis failed to comply with one or more inclusion criteria (participants, intervention and/or comparators). We then went beyond the protocol and searched for non-randomized trials and case series, but no intervention was found where stretching was the differentiating factor. We found no trials specifically assessing the effects of stretching on recovery or improvement of groin pain or injury in athletes. Currently, the efficacy of these interventions is unknown, and more research is warranted.
Micro-CT for Biological and Biomedical Studies: A Comparison of Imaging Techniques
Authors: Keklikoglou Kleoniki , Arvanitidis Christos , Chatzigeorgiou Georgios , Chatzinikolaou Eva , Karagiannidis Efstratios , Koletsa Triantafyllia , Magoulas Antonios , Makris Konstantinos , Mavrothalassitis George , Papanagnou Eleni-Dimitra , Papazoglou Andreas S. , Pavloudi Christina , Trougakos Ioannis P. , Vasileiadou Katerina , Vogiatzi Angeliki
Published: September 2021

Several imaging techniques are used in biological and biomedical studies. Micro-computed tomography (micro-CT) is a non-destructive imaging technique that allows the rapid digitisation of internal and external structures of a sample in three dimensions and with great resolution. In this review, the strengths and weaknesses of some common imaging techniques applied in biological and biomedical fields, such as optical microscopy, confocal laser scanning microscopy, and scanning electron microscopy, are presented and compared with the micro-CT technique through five use cases. Finally, the ability of micro-CT to create non-destructively 3D anatomical and morphological data in sub-micron resolution and the necessity to develop complementary methods with other imaging techniques, in order to overcome limitations caused by each technique, is emphasised.
Optimizing the Simplicial-Map Neural Network Architecture
Authors: Paluzo-Hidalgo Eduardo , Gonzalez-Diaz Rocio , Gutiérrez-Naranjo Miguel A. , Heras Jónathan
Published: September 2021

Simplicial-map neural networks are a recent neural network architecture induced by simplicial maps defined between simplicial complexes. It has been proved that simplicial-map neural networks are universal approximators and that they can be refined to be robust to adversarial attacks. In this paper, the refinement toward robustness is optimized by reducing the number of simplices (i.e., nodes) needed. We have shown experimentally that such a refined neural network is equivalent to the original network as a classification tool but requires much less storage.
Predicting Food-Safety Risk and Determining Cost-Effective Risk-Reduction Strategies
Authors: Nganje William , Burbidge Linda , Denkyirah Elisha , Ndembe Elvis
Published: September 2021

Food safety is a major risk for agribusiness firms. According to the Centers for Disease Control and Prevention (CDC), approximately 5000 people die annually, and 36,000 people are hospitalized as a result of foodborne outbreaks in the United States. Globally, the death estimate is about 42,000 people per year. A single outbreak could cost a particular segment of the food industry hundreds of millions of dollars due to recalls and liability; these instances might amount to billions of dollars annually. Despite U.S. advancements and regulations, such as pathogen reduction/hazard analysis critical control points (PR/HACCP) in 1996 and the Food Modernization Act in 2010, to reduce food-safety risk, retail meat facilities continue to experience recalls and major outbreaks. We developed a stochastic-optimization framework and used stochastic-dominance methods to evaluate the effectiveness for three strategies that are used by retail meat facilities. Copula value-at-risk (CVaR) was utilized to predict the magnitude of the risk exposure associated with alternative, cost-effective risk-reduction strategies. The results showed that optimal retail-intervention strategies vary by meat and pathogen types, and that having a single Salmonella performance standard for PR/HACCP could be inefficient for reducing other pathogens and food-safety risks.
Towards a Dialect History of the Baggara Belt
Authors: Manfredi Stefano , Roset Caroline
Published: September 2021

The Baggara Belt constitutes the southernmost periphery of the Arabic-speaking world. It stretches over 2500 km from Nigeria to Sudan and it is largely inhabited by Arab semi-nomadic cattle herders. Despite its common sociohistorical background, the ethnography of Baggara nomads is complex, being the result of a long series of longitudinal migrations and contacts with different ethnolinguistic groups. Thanks to a number of comparative works, there is broad agreement on the inclusion of Baggara dialects within West Sudanic Arabic. However, little or nothing is known of the internal classification of Baggara Arabic. This paper seeks to provide a comparative overview of Baggara Arabic and to explain dialect convergences and divergences within the Baggara Belt in light of both internally and externally motivated changes. By providing a qualitative analysis of selected phonological, morphosyntactic, and lexical features, this study demonstrates that there is no overlapping between the ethnic and dialect borders of the Baggara Belt. Furthermore, it is argued that contact phenomena affecting Baggara Arabic cannot be reduced to a single substrate language, as these are rather induced by areal diffusion and language attrition. These elements support the hypothesis of a gradual process of Baggarization rather than a sudden ethnolinguistic hybridization between Arab and Fulani agropastoralist groups. Over and above, the paper aims at contributing to the debate on the internal classification of Sudanic Arabic by refining the isoglosses commonly adopted for the identification of a West Sudanic dialect subtype.
The Effects of Fiber Inclusion on the Evolution of Desiccation Cracking in Soil-Cement
Authors: Xu Yaxing , Yao Xin , Zhuang Yan , Duan Wei , Zhang Xidong , Hu Shunlei , Dong Xiaoqiang
Published: September 2021

Desiccation cracking frequently occurs in mud, clay, and pavement. Understanding the evolution of desiccation cracking may facilitate the development of techniques to mitigate cracking and even prevent it from developing altogether. In this study, experimental investigations were performed focusing on the effects of fibers on the evolution of desiccation cracking in soil-cement. Varied types of fibers (i.e., jute fiber and polyvinyl alcohol fiber (PVA)) and fiber contents (i.e., 0%, 0.25%, 0.5%, and 1%) were involved. The digital image correlation (DIC) method was employed to capture the evolution and propagation of cracks in the soil-cement specimens when subjected to desiccation. The results show that the presence of fibers imposes significant effects on the crack propagation pattern as well as the area and length of the cracks in the soil-cement during shrinkage. The addition of fibers, however, insignificantly affects the evaporation rate of the specimens. The crack area and crack length of the specimens decreased significantly when more fibers were included. There were no macroscopic cracks observed in the specimens where the fiber content was 1%. The DIC method effectively helped to determine the evolution of displacement and strain field on the specimens’ surface during the drying process. The DIC method is therefore useful for crack monitoring.
A Cop and Drunken Robber Game on n-Dimensional Infinite-Grid Graphs
Authors: Songsuwan Nuttanon , Jiarasuksakun Thiradet , Tangthanawatsakul Anuwat , Kaemawichanurat Pawaton
Published: September 2021

A Cop and Drunken Robber (CDR) game is one variation of a famous combinatorial game, called Cops and Robbers, which has been extensively studied and applied in the area of theoretical and computer science as demonstrated by several conferences and publications. In this paper, for a natural number n, we present two strategies for a single cop to chase a drunken robber on n-dimensional infinite-grid graphs. Both strategies show that if the initial distance between the cop and the drunken robber is s, then the expected capture time is s+o(s).
The Design of a Wideband Antenna with Notching Characteristics for Small Devices Using a Genetic Algorithm
Authors: Awan Wahaj Abbas , Zaidi Abir , Hussain Musa , Hussain Niamat , Syed Ikram
Published: September 2021

This paper presents the design and realization of a compact printed ultra-wideband (UWB) antenna with notching characteristics for compact devices using a genetic algorithm. The antenna is capable of mitigating an adjacent sub-band ranging from 3.75 to 4.875 GHz, mainly used by many applications and standards such as WiMAX, WLAN and sub-6-GHz. The notch band functionality is achieved by etching out two symmetrical slots from the pentagonal radiating element. The simulation and measured results demonstrate that the proposed antenna overperformed compared with state-of-the-art antennas in terms of compactness with an overall size of 20 mm×15 mm×0.508 mm. Moreover, the proposed design shows a large bandwidth in the UWB region with a fractional bandwidth of 180% with respect to the center frequency of 5.25 GHz. The antenna also presents omnidirectional radiations all over the operation band and a good return loss performance.