bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of The Covid-19 Pandemic on Financial Performance of Logistics and Delivery Companies Listed on ISSI
Authors: Kurnia Muhamad Rizal , Syihabudin Syihabudin , Najmudin Najmudin
Published: May 2022

The limited activities outside the home due to the Covid-19 pandemic have made people spend more online shopping. The rapid development of e-commerce and online shopping has become a huge opportunity in the logistics and delivery (courier) sector because it is one of the essential industries that is allowed to continue operating and a sector that plays a vital role in supporting the community's economy during the Covid-19 pandemic. This study aims to determine the impact of the Covid-19 pandemic on the financial performance of logistics and shipping companies listed on the Indonesian Sharia Stock Index (ISSI). This research method uses descriptive quantitative using financial ratio calculations to describe the company's financial performance which is used is ROA, NPM, and DER. The data source is secondary data for the 2019-2021 quarterly financial statements at PT Satria Antaran Prima Tbk and PT Trimuda Nuansa Citra Tbk. obtained from the idx.co.id website page. The results of this study indicate that before the 2019 Covid-19 pandemic, the company's financial performance on ROA and NPM increased and DER tended to decrease. During the Covid-19 pandemic in 2020-2021 ROA and NPM decreased and DER increased. Company's financial performance logistics and delivery shows that before Covid-19 was better than during the Covid-19 pandemic
Digitalisasi Pembiayaan: Atensi UMKM Dalam Memanfaatkan Pembiayaan Peer To Peer Lending
Authors: Saputri Novitasari Agus , Haryanti Agustin Dwi , Nur Thoufan
Published: May 2022

This study aims to analyze the attention and motivation of Micro, Small and Medium Enterprises (MSMEs) towards online funding that utilizes technology. Indonesia has issued a regulation through the Financial Services Authority (OJK) Number 77/POJK.01/2016 concerning Information Technology-Based Lending and Borrowing Services. This service is the provision of financial services to bring together lenders and loan recipients through an electronic system using the internet network. OJK regulations have given birth to several of these service providers. OJK recorded 164 (one hundred and sixty four) legal financial technology (fintech) companies developing in Indonesia. The fintech company managed to record 18,569,123 (eighteen million five hundred sixty-nine thousand one hundred twenty-three) borrower accounts. This service is able to channel funding of Rp. 81,497,051,000,000,- (eighty one trillion four hundred ninety seven billion fifty one million rupiah). Data and information are recorded on the OJK website, namely www.ojk.go.id. The results of this study have an R2 value of 15.3% which shows that the influence of risk variables, understanding of finance and the ease of using fintech on interest in using fintech in terms of financing, namely Peer To Peer Landing. This value is very small when compared to other influential variables. The value of 84.7% is most likely influenced by other variables
Pengaruh Motivasi, Persepsi Return, dan Kemajuan Teknologi Informasi terhadap Pertimbangan Investasi Syariah dengan Perilaku Keuangan sebagai Variabel Moderasi
Authors: Kusuma Riana Adhistyaning , Hakim Luqman
Published: May 2022

The growth in the number of Islamic investors has doubled compared to the end of 2020. However, there are still many students who have not allocated their funds to invest, students only save funds in the form of savings. This research aims to determine the effect of motivation, return perception, and advances in information technology in considering investing in the Islamic capital market with financial behavior as a supporter of each variable. The research method in this research uses quantitative research with data collection techniques through the distribution of online questionnaires. This study used a sample of 144 respondents, and analyzed using the Structural Equation Modeling (SEM) technique which is a derivative of the WarpPLS 7.0 application. The results of the analysis in this research state that motivation, perceived returns and advances in information technology have a direct and significant effect. In addition, financial behavior cannot moderate the motivation and perception of return on sharia investment considerations. Financial behavior can moderate the perception of return on investment considerations for state university LPTK students in Indonesia
Pengaruh Faktor Harga, Keamanan, Kemudahan, dan Kepercayaan Terhadap Perilaku Belanja Online Dimasa Pandemi Covid-19
Authors: Rahayu Listia Puji , Susanti Ari
Published: May 2022

Shopping on online sites is one of the shopping systems of choice for many consumers today because the transaction process is easy and fast, as well as safer and does not cause bad effects that worry others, especially in the current conditions with the Covid-19 Pandemic. The purpose of this research is to analyze online shopping behavior in Indonesia, especially during the Covid-19 pandemic, by proving whether there is an influence of trust, convenience, security, and price factors on online shopping behavior or not. The research method uses quantitative methods. In this research, the size of the population is unknown or unlimited because of the large number of consumers who shop online. The size of the sample in this study amounted to 170 respondents, and identified using the Hair formula. The sampling technique used in this research is purposive sampling method which is limited by several criteria. The results obtained in this study are, Trust, and Price affect online shopping behavior in the future, while Ease and Security have no effect on online shopping behavior during the Covid-19 Pandemic
Pengaruh Pemahaman Sistem Akuntansi, Pengelolaan Keuangan, Kapasitas Sumber Daya Manusia Terhadap Kualitas Laporan Keuangan
Authors: Setyobudi Setyobudi
Published: May 2022

This study aims to understand the financial accounting system and financial management, the capacity of human resources partially or simultaneously influences the quality of information on the financial statements of the local government of Pati Regency. The sampling technique used was purposive sampling. Respondents sampled in this study, namely employees who work at the Pati Regency SKPD environmental service in the 2021 financial report, bear the WTP predicate six times from the BPK. In this study, certain criteria were used, namely employees of the finance department, having a minimum education level of high school/equivalent and having worked for at least 1 year. The types of data used in this study are primary and secondary data. The primary data in this study were the respondents' answers to the questionnaires distributed. Secondary data in this study is the organizational structure, and an explanation or general description of the organization as well as data on the number of employees in the finance department in each department. Testing the data is done by testing the validity and reliability test, multicollinearity test, and heteroscedasticity test, while hypothesis testing with multiple regression analysis using the SMART PLS program.3. The results showed that both partially and simultaneously Understanding of Regional Financial Accounting Systems, Regional Financial Management, and Human Resource Capacity had a positive and significant effect on the Quality of Information on Local Government Financial Reports
Analisis Pengaruh Iklim Kerja dan Komitmen Organisasi terhadap Kinerja Pegawai
Authors: Rahman Al Hakim Yusuf
Published: May 2022

Employees are the greather crucial elemental of quality human resources of an educational institution in achieving national education goals. This achievement requires high employee performance in every training and learning process all education. Employees with high performance are thought to be influenced by the work climate and organizational commitment in an effort to achieve the achievement and quality of teaching as well as the expected quality of learning. The purpose of this study was to examine this relationship at a university in Surabaya as the object of research. The sample was obtained as many as 63 respondents through simple random sampling method and then the data was analyzed in several stages. The results obtained are the results of this study concluded that the formation of employee performance in the field of education has a significant role from the work climate and organizational commitment partially and simultaneously
Pengaruh Persepsi Guru dan Motivasi Guru Terhadap Kinerja Guru di UPT Pendidikan Kec. Arjasa
Authors: Dewi Nuning Nurna
Published: May 2022

This study was to determine the effect of teachers' perceptions of principal supervision on teacher performance at UPT Pendidikan Kec. Arjasa who implements the Semester Credit System in Sumenep Regency. to determine the effect of teacher motivation on teacher performance at UPT Pendidikan Kec. Arjasa who implements the Semester Credit System in Sumenep Regency. to determine the effect of teachers' perceptions of principal supervision and teacher motivation simultaneously on teacher performance at UPT Pendidikan Kec. Arjasa who implements the Semester Credit System in Sumenep Regency. To take a predetermined sample from the population, a sampling technique is used, which in this case will be applied based on a percentage of 50% of the population, namely 50/100 x 106 = 53 teachers with proportional sampling technique based on the number of fields of study in the institution concerned. with the data collection method used in this study is the instrument formed a questionnaire (questionnaire) and observation Teachers who have a good perception of the principal's supervision will teach well, because supervision means coaching teachers towards improvements in teaching. On the other hand, if the advice from the supervisor is ignored by the teacher, it can have an impact on teaching activities that are not good. This is related to the encouragement/motivation by the principal to improve teacher performance. the influence of teachers' perceptions of principal supervision and teacher motivation on teacher performance at UPT Pendidikan Kec. Arjasa who implements the Semester Credit System in Sumenep Regency. The principal plays a very important role in creating the spirit and motivation of teachers in carrying out their duties. Successful principals must have the ability to encourage the emergence of a strong will and confidence in teachers and staff in carrying out their respective duties for the progress of the school in achieving its goals
Customer Satisfaction on Yamaha Motorcycles: A Study of Product Differentiation and Brand Reputation
Authors: Harjadi Dikdik , Arraniri Iqbal , Sagita Diki
Published: May 2022

This study aims at analyzing the effect of product differentiation and brand reputation on customer satisfaction of Yamaha motorcycle products. To collect data, questionnaires were distributed to 100 respondents selected through accidental sampling method. Meanwhile, descriptive and verification testing methods were used to analyze the collected data. Besides, multiple linear regression was also used to construct the variables, namely product differentiation (X1), brand reputation (X2), and customer satisfaction (Y). As results, this study found that product differentiation and brand reputation have a significant effect on costumer satisfaction
Determination of the Effects on Meat Quality and Fatty Acids of Different Boron Sources in Akkaraman Lambs
Authors: SARIÇİÇEK Zehra , YILDIRIM Birgül
Published: May 2022

In this study, the effects of boron sources such as colemanite, ulexite and etibor-48 supplementation on meat quality and fatty acid composition of Akkaraman lambs weaned at 2.5 months of age were investigated. In the study, 50 single Akkaraman male lambs weaned at the age of 2.5 months were used as animal material. Concentrated containing (17.56% CP and 2600 Kcal/kg ME) and forage (meadow hay) were used as feed material. Colemanite (50.8% B2O2, Ca2B6O11.5H2O), ulexite (43% B2O3, NaCaB5O9.8H2O) and etibor-48 (48%, Na2(OH)2.8H2O) as boron sources were used. The highest protein content of Akkaraman lamb meat was obtained from C and S groups, and the lowest in L group (P
Perubahan Output dan Kinerja Sektor Pariwisata di Bali Dalam Masa Pandemi Covid 19
Authors: Octaviani Silmi Nur , Arif Muhammad
Published: May 2022

Tourism is one of the sector that greatly affect the country’s income. The tourism sector is the second largest foreign exchange contribution for Indonesia. Bali is one of the provinces that are often visited by local and foreign people. The existence of coronavirus or covid 19 pandemic, makes all matters related to tourism in Bali temporarily stopped. This resulted in the tourism sector experiencing a decline due to covid 19 pandemic. The purpose of this study is to analyze the performance of the tourism sector during the covid 19 pandemic in 2020-2021. This study uses input-output analysis method. The type of data used in this study is secondary data. The results showed that tourism sector during the pandemic experienced turmoil that resulted in a decrease in demand for final output of the economy and Bali’s economic growth is declining during the covid 19 pandemic.
Optimalisasi Zakat Produktif Pada Peningkatan Usaha Mikro Mustahik (Studi Kasus Pada Program Purbalingga Sejahtera BAZNAS Kabupaten Purbalingga)
Authors: Ningsih Oktia , Hadi Ramini
Published: May 2022

The problem of poverty that still exists today cannot be separated from the low economic income of the community. One of the causes of poverty in Indonesia is that the poor have difficulty raising capital. Zakat can be relied upon as a mechanism to overcome this problem, of course changing the distribution system which is generally consumptive in nature to be productive or in other words zakat is not only used once but has other impacts for development. The purpose of this study was to determine the optimization of productive zakat on increasing mustahik micro businesses in the Purbalingga Sejahtera Program at BAZNAS Purbalingga Regency. The type of research used is field research or direct research conducted in the field or on informants. This research was conducted using a qualitative method with a descriptive approach. After conducting research and analysis, it can be concluded that the optimization of productive zakat in increasing mustahik micro businesses in the Purbalingga Sejahtera Program implemented by BAZNAS Purbalingga Regency is not optimal. This is because, every indicator to assess the optimization of a program is correct and correct. Furthermore, to further optimize the Purbalingga Sejahtera Program, namely productive zakat funds in achieving program goals, BAZNAS Purbalingga Regency is to be able to improve again in terms of assistance to mustahik as a whole. The limited number of amil, it is recommended to open volunteers from students of zakat and waqf management study programs.
Association of Adiponectin Levels with Polycystic Ovarian Syndrome
Authors:   Nishter Hospital, Multan, Iqbal Muhammad Noman
Published: May 2022

Objective: To measure the levels of adiponectin in women with PCOS having high body mass index. Methodology: A cross-sectional study including 96 study participants was conducted in Services Hospital, Lahore in December 2020 out of 96 study participants 48 were enrolled as cases having polycystic ovarian syndrome compared with 48 healthy women as controls. Detailed information about age, duration of menstrual cycle, body mass index (BMI), and clinical features like obesity, infertility, acne and hairs on face were noted. A total 5ml venous blood was collected by using aseptic techniques and then centrifuged immediately; serum was separated and stored at -20 °C after proper labeling. Samples were analyzed for estimation of serum adiponectin by using enzyme linked immunosorbent assay. Statistical analysis was carried out by statistical package for social sciences (SPSS) 21. The p-value < 0.05 was considered to be statistically significant. Results: In this study level of adiponectin was decreased in PCOS women as compared to healthy women. Mean ± SD of adiponectin in PCOS women was 2.08±0.70µg/ml which was lower than in control group 9.71±5.35µg/ml. Median/Inter Quaitel Range of PCOS women was 2.00/0.78 which is lower in comparison with the Median/IQR of adiponectin in healthy women 8.60/9.63, p-value of adiponectin was significant (p = 0.00). Conclusion: Adiponectin is important variable present in circulation. Its levels are changed in response to disease process as occurs in PCOS.
Factors Influencing the Whistleblowing System in the Government of Jakarta Capital Special Region, Indonesia
Authors:   Faculty of Economics and Business, Universitas Jenderal Soedirman, Indonesia, Mustafa Rasyid Mei
Published: May 2022

This study aims to examine factors influencing the whistleblowing system in the governmental institution (i.e., attitude-behavior, norm values, and employee solidarity) which is represented by the government of Jakarta Capital Special Region (Daerah Khusus Ibukota/DKI). A quantitative approach is used to collect the data by giving questionnaires to the respondents in all institutions of regional apparatus of the work unit (satuan kerja perangkat daerah/SKPD) in Jakarta with the total sample selected being 42. Respondents were selected using a puIDRosive sampling method where one SKPD was given one questionnaire. The findings show that all of the independent variables (i.e., attitude-behavior, norm values, and employee solidarity) do not have an influence on the occurrence of whistleblowing in SKPD of Jakarta Capital Special Region. The implication of this research is the need to install knowledge in employees about the meaning of the whistleblowing system, increase the role of norms that regulate employee mindsets, and increase the awareness of fellow employees about creating an anti-fraud culture. It is important to consider the aspect of culture in future studies.
Ergonomics in Remote work TV
Authors:   Specialist, Santa Úrsula University in Rio de Janeiro-RJ, Brazil, Bogossian Tricia
Published: May 2022

The study presented seeks to report ergonomics with remote work, highlighting some of the main characteristics related to the use of ergonomics with work routines. The same has the general objective to characterize and analyze the occupational activity from the ergonomic point of view of the worker. The specific objectives are: to identify and describe the importance and procedures that must be adopted in ergonomics; analyze and identify adverse conditions and good practices at work from the perspective of health and safety at work and describe how ergonomics can be inserted together with remote work. For greater stability of the contents presented, a literature review was carried out, based on works published over the last 20 years, in order to consolidate how ergonomics can be something fundamental within the work environment.
ANALISIS KOMPARATIF INCOME STATEMENT APPROACH DAN VALUE ADDED APPROACH PADA KINERJA KEUANGAN PERBANKAN SYARIAH (STUDI PADA BANK MUAMALAT CABANG MAKASSAR)
Authors: Jumardi Jumardi , Nurhayani Nurhayani , Suhartono Suhartono
Published: May 2022

Penelitian ini bertujuan untuk menganalisis perbedaan kinerja keuangan bank syariah dengan menggunakan income Statement Approach dan Value Added Aproach berdasarkan rasio keuangan. Rasio keuangan yang digunakan terdiri dari ROA, ROE, rasio perbandingan antara total laba bersih dengan total aktiva produktif, NPM, dan BOPO. Objek yang digunakan dalam penelitian ini adalah PT. Bank Muamalat Indonesia Cabang Makassaer. Jenis Penelitian ini adalah penelitian dokumenter dimana sulmber data adalah laporan keuangan PT. BMI Cabang Makassar, dalam hal ini laporan keuangan tahun 2007-2011 untuk masing-masing pendekatan yaitu Income Statement Approach dan Value Added Approach. Alat analisis yang digunakan untuk membuktikan hipotesis penelitian ini adalah statistik deskriptif kuantitatif dan analisis uji beda t-test. Hasil penelitian menunjukkan bahwa rata-rata rasio keuangan (ROA, ROE, perbandingan laba bersih dengan aktiva produktif, dan NPM) terdapat perbedaan yang signifikan antara Income Statement Approach dan Value Added Approach, sedangkan pada rasio BOPO antara Income Statement Approach dan Value Added Approach tidak terdapat perbedaan. Akan tetapi bila dilihat secara keseluruhan tingkat profitabilitas menunjukkan adanya perbedaan yang signifikan antara Income Statement Approach dan Value Added Approach.
PENGARUH MODAL ANGGOTA KOPERASI DAN JUMLAH ANGGOTA TERHADAP SISA HASIL USAHA PADA KOPERASI UNIT DESA LAMATTI RIATTANG KECAMATAN BULUPODDO KABUPATEN SINJAI
Authors: Subhan Subhan , Nabir Abd Muhaemin , Riana Ira
Published: May 2022

Penelitian ini berjudul  pengaruh modal anggota koperasi dan jumlah anggota terhadap sisa hasil usaha pada koperasi unit desa lamatti riattang kecamatan bulupoddo kabupaten sinjai. Berfokus pada pengeruh modal anggota koperasi dan jumlah anggota terhadap sisa hasil usaha pada koperasi unit desa lamatti riattang kecamatan bulupoddo kabupaten sinjai, penelitian ini adalah penelitian survey dengan menggunakan  pendekatan kuantitatif. Dengan sumber data primer dan data sekunder. Metode yang digunakan  yaitu observasi, angket, dan dokumentasi. Sedangkan tehnik  analisis data uji stastistik deskripsi, uji asumsi klasik dan uji hipotasis.hasil penelitian menyatakan bahwa modal dan jumlah anggota koperasi berpengaruh positif dan signifikan terhadap sisa hasil usaha koperasi. Hal ini dapat diperkuat atau dibuktikan dan didukung oleh nilai sig. Lebih kecil dari nilai alpha yaitu 0,000 < 0,05 artinya nilai signifikan variabel dependen (x) berpangaruh positif dan signifikan terhadap variabel independen (y).  Tabel yaitu 5,506 > 0,004 artinya h0 ditolak dan ha diterima. Dari hasil olahan data nilai r square tersebut diperoleh nilai koefisien determinasi 0,520. Artinya besarnya variabel dependen (x) terhadap sisa hasil usaha koperasi (y) adalah 52,0%. Sehingga ini menunjukkan bahwa modal dan jumlah anggota koperasi memiliki pengaruh positif dan signifikan terhadap sisa hasil usaha pada koperasi unit desa lamatti riattang kecamatan bulupoddo kebupaten sinjai.
Bir Karış Fazla Şimendifer: Osmanlı’dan Cumhuriyet’e Demiryolu Politikasının Değişimi
Authors: AKCAKAYA Umut
Published: May 2022

Osmanlı yöneticileri, XIX. yüzyıl ortasında gelişen demiryolu teknolojisinin önemini anlamakta geç kalmamış ve bu teknolojiyi ülkeye getirmekte istekli olmuştur. Bu tercihte, demiryolları sayesinde üretim ve ticaret hacminin artacağı düşüncesi belirleyici olmuştur. Bu sayede devletin çok ihtiyaç duyduğu gelir artışının sağlanabilecektir. Ayrıca modernleşme hareketinin gereği olarak merkezi denetimin kuvvetlendirilmesi de mümkün olacaktır. Ancak teknolojik ve ekonomik yetersizlikler ile siyasi bağımlılık, Osmanlı Devleti’nin bağımsız bir demiryolu politikası izlemesine imkân vermemiştir. Yabancı sermaye tarafından inşa edilen demiryolu hatları, ihracata yönelik tarımsal ürünler üreten bölgeleri liman kentlerine bağlama amacını gütmüştür. Buna karşın ülkenin iç ekonomik ve sosyal bütünleşmesi ile siyasi ve askeri gereklilikler göz ardı edilmiştir.

Cumhuriyet kadrolarının demiryolundan beklentileri, temelde Osmanlı yönetimininkinden farklı olmamıştır. Ancak Milli Mücadele’den bağımsız bir devlet olarak çıkan Türkiye Cumhuriyeti, Osmanlı Devleti’nin aksine, bağımsız bir demiryolu politikası belirleyecek güce sahip olmuştur. Demiryolu politikası, dış baskılarla değil ülkenin kalkınması ve savunulması gibi milli ihtiyaçlara göre tespit edilmiştir. Demiryolu inşasında üretim merkezlerini tüketim merkezlerine bağlayarak iktisadi bir denge kurmak, bunun yanında demiryollarının geçtiği bölgelerde iktisadi hayatta olduğu kadar sosyal hayat üzerinde de bir gelişmenin sağlanması amaçlanmıştır.
Tanzimat Dönemi’nde Golos Kazası’nda İmar Faaliyetleri
Authors: YÖRÜKOĞULLARI Merve
Published: May 2022

19. yüzyılda meydana gelen Sanayi Devrimi’nin ardından dünya genelinde büyük bir değişim ve dönüşüm yaşanmıştır. Bu dönemde yaşanan değişimlerin en somut örneği kentlerin alt ve üst yapılarında meydana gelen gelişmelerdir. Avrupa’da meydana gelen bu gelişmeler Osmanlı’ya yansımakta gecikmemiştir. Nitekim, Tanzimat’ın ilanıyla uygulanan reform çalışmaları çerçevesinde başlayan imar faaliyetleri liman kentlerinde daha belirgin bir şekilde ortaya çıkmıştır.

Tesalya Bölgesi’nin önemli limanlarından biri olan Golos Kazası’nda bu dönemde önemli imar faaliyetleri gerçekleşmiştir. Şehir, Yunanistan’ın Doğusu’nda Ege Denizi kıyısında bulunmaktadır. Tırhala Sancağı’na bağlı küçük bir yerleşim birimi olan şehir, Tanzimat ile birlikte hızlı bir şekilde modernleşme sürecine girmiştir. Bu denli hızlı gelişme ve modernleşme şehrin coğrafi yapısından kaynaklanmaktadır. Kaza’nın bulunduğu Tesalya toprakları oldukça verimli olup, başta tarım olmak üzere elde edilen ürünlerin ihraç edilmesinde Golos Limanı önemli bir işlev görmüştür. Ticari faaliyetlerin gelişmesiyle birlikte şehrin fiziki yapısı değişmiştir. Karayolları modernize edilmiş ve demir yollarının yapımı ile iç bölgelerdeki ürünlerin kıyı kentlerine taşınması sağlanmıştır. Telgrafın gelmesiyle birlikte farklı bölgeler arasında ticari faaliyetler artmıştır. Aynı zamanda savunma açısından da önemli bir konumda bulunmasından dolayı şehirde askeri amaçlı yerler tamir ve inşa edilmiştir. Gerçekleştirilen imar faaliyetleri sonucu kısa bir zamanda büyük bir gelişme göstererek modern bir liman kenti haline gelmiştir.
Review. The story of melanocyte: long way from bench to bedside
Authors: Shahbazi Atefeh , Zargar Seyed Jalal , Motamed Nasrin , Aghdami Nasser , Shafieyan Saeed
Published: May 2022

Skin is composed of major layers, a superficial epidermis and a deeper dermis. The color of skin is influenced by a number of pigments, including melanin. Melanin is produced by cells called melanocytes. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal. A couple of the more noticeable disorders, namely albinism and vitiligo, affect the appearance of the skin and its accessory organs. Vitiligo is associated with significant psychosocial morbidity and profound effect on quality of life.
 Topical steroids, calcineurin inhibitors, phototherapy and surgery are most common treatments. However, there are many patients who do not respond to any of these modalities. The transplantation of cultured or non-cultured melanocyte is the most important treatment for hypopigmentory disorders. In this study, we are going to assess the history of melanocyte cultivation and evaluate the effectiveness of transplantation cultured cells.
We examined the beginning process of isolation, characterization, and transplantation of epidermal cells. This review, summarize our current understanding of the cutaneous pigmentary system from the start of synthesis in the pigment cells, along with the response of repigmentation. During the production of melanin, melanosomes are transferred to neighboring keratinocyte in order to form perinuclear melanin caps. The objective of this review is to analyze the melanocytes transplantation in the last century up to now, and how epidermal cells can increase pigmentation in hypo-pigmented areas in skin disorders. Also, we focus on the story of the melanocyte back to 1950. 
In addition, prior systemic therapy was associated with a significant increase significant increase based on combined additional therapy, achieving desired results and improved outcomes. Despite the short study of a long way of melanocyte assessment and follow up patient's treatment, results of the all reports were confirmed the efficacy of the used method in the treatment of stable vitiligo who did not respond to the common algorithms of non-invasive treatments.
The use of double-acting cylinders in electro-hydraulic circuit
Authors: Duțu I.C , Axinte T , Maican E , Nuțu C , Diaconu M
Published: May 2022

The paper presents aspects related use of double-acting cylinder. Besides, in the article are presented three hydraulic schemes that double acting cylinder. Meaning, two hydraulic circuits and one electro-hydraulic circuits. First hydraulic schemes has the following devices: fixed displacement pump, air filter, 4/3 way hand lever valve, tanks reservoir, filter and double acting cylinder (Cyli 1-1). However, second hydraulic scheme has the following devices: fixed displacement pump, 4/3 way hand lever valve, check valves, valve office and two double acting cylinders (Cyli 2-1 and Cyli 2-2). Forward, the electro-hydraulic circuit has the following devices: tanks, throttle check valves, 5/2 way hand lever valve, fixed displacement pump, lamp, relays, relay with switch-on delay, valve solenoid and double acting cylinder (Cyli 3-1). The design and simulation of the all three circuits from this article is done FluidSim software from Festo.
The Effects of Vitamin B6, Vitamin D and Antioxidants on Hyperpigmentation
Authors: Prabha.G Dr Ramya Bala , Rao.T Rama , Lakshmi Palle Sree , Shareef Mohd Qhader , kumari.C Jeevana
Published: May 2022

A growing body of evidence reveals that a healthy, well-balanced diet substantially impacts skin ageing. The compounds that maintain and restore the epidermal barrier, which lowers TEWL, ensures an optimal skin moisture level, and protects against external causes and inflammation-induced damage, deserve special attention (e.g., omega-3 and omega-6 fatty acids). Antioxidants and other phytonutrients that scavenge ROS and reduce oxidative skin damage, as well as compounds that protect the skin from the harmful effects of U.V. radiation, play an essential role in the prevention and care of ageing skin (including vitamins A, C and E; selenium; zinc; copper; silicon; polyphenols; and carotenoids). Antioxidants taken orally can supplement chemical and physical UV-filtering agents, reducing DNA damage that causes skin ageing and cancer. Incorporating these nutrients into one's everyday diet could be an excellent way to combat the effects of ageing. Finally, encouraging healthy eating habits can improve skin look, slow down the ageing process, and lower the risk of skin cancer.
Ectopic Pregnancy: A Major Occurring Problem
Authors: Pallavi B. , Harshitha V. Sai , Rao S. Shanmukha , Balaprabha G. Ramya , Rao Rama
Published: May 2022

Ectopic pregnancy occurs when the fetus implants outside the uterus or to an abnormal portion of the uterus. It is the result of flaw in the reproductive physiology that allows the fetus to implant outside the endometrial cavity. This leads to the death of the fetus. Ectopic pregnancy is the main cause of maternal death in early pregnancy. Nearly 0.25-2.0% of pregnancies are ectopic.0.91% of pregnant women were reported with ectopic pregnancy in a study done at tertiary care hospital in South India. Medication: If the fallopian tube has not ruptured medication alone can help the situation. Methotrexate, a folic acid antagonist which inhibits DNA synthesis and cell replication is used. The mechanism of action is to kill cytotrophoblast cell that dividing rapidly at the fallopian tube which then the body spontaneously reabsorbs. Laparoscopy is done for pregnant women with extensive bleeding, or poor visualization of the pelvis. Women with the history of ectopic pregnancy should have an early diagnosis. Women with any infections or pelvic inflammatory diseases should get regular checkups. Laparoscopy is the gold standard surgical treatment for ectopic pregnancy in those women with ruptured fallopian tube.
Young Onset Type 2 Diabetes Mellitus: A Review
Authors: Bollam Akhila , Patlolla Priyanka , Balaprabha Ramya , Rao Rama
Published: May 2022

Diabetes is an increasing global problem. Youth onset type2 diabetes mellitus is increasing in many countries. Early onset type 2 diabetes is increasingly prevalent with significant impact on individual or healthcare service. The individuals with history of type 2 diabetes, obese and leading sedentary life style, black or minority or ethnic group has higher risk of type 2 diabetes mellitus. Individuals with type 2 diabetes have higher risk of complications. Specific symptoms in young people include growth impairment, unexplained loss of weight and wetting of bed. Obesity, particularly abdominal obesity, PCOS, pubertal age group and intrauterine exposure to hyperglycemia are among the risk factors for development of T2DM in children and adolescents. Symptoms of diabetes and random plasma glucose concentration, or glycated haemoglobin or fasting plasma glucose or 2 h plasma glucose during oral glucose tolerance test may be used for diagnosing diabetes. Initial treatment of youth-beginning sort 2 diabetes should incorporate metformin as well as insulin alone or in combination, in view of the metabolic status of the patient. Initial treatment of youthbeginning sort 2 diabetes should incorporate metformin as well as insulin alone or in combination, in view of the metabolic status of the patient. Early onset type 2 diabetes is more aggressive and has higher complications and comorbidities. Youth onset type 2 diabetes creates large personal and societal burden so adequate educational and psychological support should be given. This review on young onset diabetes mellitus provides knowledge on emerging epidemic.
Personal Formulary for Otitis Media Developed by Residents of Pharmacology
Authors: Mohan Lalit , Hameed Saajid , Kumar Manish , Kumar Arun , Dikshit Harihar
Published: May 2022

Background: The choice of antibiotics is not always carefully made as it is often based on previous experience or promotional campaigns by pharmaceutical companies. To bring order to the crisis and reduce the availability of hospital-based drugs to those who are most needed and effective in their field, P-Drug development is needed. The purpose of personal design is to promote safe, effective, and economical decision-making. Aim: To develop personal formulary for otitis media. Materials and Method: Residents were taught about how to analyze and give score (α) to drugs used for otitis media available in market. Four parameters according to P-drug concept of Joshi and Jayawick Ramarajah, efficacy (0.4), safety (0.3), cost (0.2) and convenience (0.1) was taken into consideration for each group and their drugs. Scores was given to each four parameters from 1 to 10 for each drug. Each parameter was given a fractional numerical rating (β) according to the importance i.e. 0.4 for efficacy, 0.3 for safety, 0.2 for cost and 0.1 for convenience. Results: Taking all of above factors in consideration, penicillin group has got highest total score and was chosen the most suitable group for making personal formulary of otitis media. Two drugs (ampicillin & amoxicillin) are commonly prescribed for otitis media. Among ampicillin and amoxicillin, amoxicillin has good oral absorption and less G.I side effects, so amoxicillin got higher efficacy and safety points. Adding clavulanate to amoxicillin increases the efficacy of amoxicillin and also augments its action against penicillinase producing bacteria without adding any additional adverse effects. So, amoxicillin + clavulanate has highest efficacy points with same safety point of amoxicillin. Conclusion: We have noticed significant improvement in attitude and skills of residents after this project. The whole exercise will be helpful in promoting rational use of medicines by students in their future career as doctors.
Formulation and Evaluation of Imiquimod Emulgel for Treatment of Common Warts
Authors: Prajapat Arti , Tikariya Komal , Mukherjee Dr. Jayanti
Published: May 2022

The objective of the present work is to develop and optimize emulgel system for epidermal and dermal delivery of drug which delivers the drug in local sites more efficiently than cream and other gel preparations. The drug imiquimod is locally acting antifungal drug with wide spectrum of anti fungal activity. Imiquimod given only topically. Well absorbed through skin. Half life: 20 hrs (topical) 2 hrs (subcutaneous). The gel were prepared by dispersing Carbopol 934 in purified water with constant stirring and Carbopol 940 in purified water with constant stirring then the pH was adjusted to 5.5 using Tri Ethanol Amine (TEA). The preparation of emulgel is based on the use of different types of gelling agent, liquid paraffin concentration and emulsifying agent concentration. It has demonstrated that the formulation possess better drug content and drug release in comparison to marketed product for local treatment of fungal diseases. The spread ability of formulations ranges from 12.10±0.95g.cm/sec to 16.57±1.17 g.cm/sec. The drug content in emulgel is 73.5 ± 1.82 % to 83.31 ± 1.20 %. The higher drug content determination in emulgel F5 and F3 are 83.31 ± 1.20 % and 80.2 ± 2.50 % respectively. The prepared formulation (emulgel) shows better release profile than marketed preparation. Emulgel will act as depot of drug which releases drug in sustained manner. Emulgel formation was confirmed by Transmission electron microscopy. The size of emulgel particle found within the range of 1μm by TEM. It concludes that the Emulgel formulation show sustained release of drug as compared to the marketed product. No irritation was found by the skin irritation test of the emulgel on the rabbit skin. The skin penetration potential of developed emulgel was further confirmed by the fluorescence microscopy for topical drug delivery. The formulations found to be stable for period of 3 months; it can be observed that the emulgel formulation showed no major alteration in relation to the pH, microbiological study, consistency, skin irritation test and in vitro release study.
JUSTIFICATION OF THE CHOICE OF TECHNOLOGICAL EQUIPMENT FOR SOD PEAT EXTRACTION FOR ACTIVATED CHARCOALS PRODUCTION
Authors: Kuntsevich V. B. , Makarenko T. I. , Ageichik I. V. , Gaidukevich O. M. , Kalilets L. P.
Published: May 2022

The results of the use of technological equipment for the extraction of sod peat as a raw material for the production of activated charcoals are presented. It is shown that more acceptable variant, from "price–quality" point of view, is the option with the use of equipment manufactured by RUE "Mogilevenergo". The modernization of the spinneret of KTD-1 machine has been substantiated, which makes it possible to obtain activated carbon of the required quality from the extracted products. The main technical and economic indicators of its application have been determined: productivity, fuel consumption and labor costs for the extraction of 1 ton of peat of standard moisture content, utilization rates of cycle and working time. It was found that replacing of standard mouthpieces with a diameter of 75 mm by mouthpieces with a diameter of 40 mm reduces the field loading density and cycle charges. At the same time, the extraction of sod peat of a smaller diameter (within the limits of the investigated ones) increases the seasonal harvest, in our experiments – by

1.4 times. Optimal schemes for the movement of machines on working aisles have been developed, which ensure highquality

performance of all operations provided for by the technological regulations. The main reasons that reduce the productivity of the KTD-1 machine when extracting sod peat with a diameter of 40 mm are established, and methods for their elimination are proposed. It is shown that for the stable operation of KTD-1 mining machine, the timber content of peat deposit should not exceed 1.5 %.
ABOUT THE INFLUENCE OF WEATHER AND CLIMATIC FACTORS ON THE GRAIN CROPS YIELD OF MINSK AND MOGILEV PROVINCES IN LATE 19th – EARLY 20th CENTURIES
Authors: Kalyada V. V.
Published: May 2022

A quantitative assessment of the influence of weather and climatic factors (average air temperature and the amount of precipitation by months of the growing season) on major agricultural crops yield was carried out using ‘weather – harvest’ regression models and available statistical and meteorological data for Minsk and Mogilev provinces in late 19th – early 20th centuries. On the basis of the established dependencies, the vulnerability of the main grain crops to the climatic conditions of the period under consideration is shown, and specific factors are identified that determine the climatic variability of their yield. Using the weather index on the example of Minsk province, the favorable weather conditions for the main grain crops growth (winter rye and oats) in the considered years were assessed. It is shown that fluctuations in yield of winter rye were determined by moisture storage on eve of sowing and the conditions of its conduction, the sizes of sowings death because of temperature and precipitation sums ratio, heat supply of a period of vegetation resumption, weather conditions of spring and summer vegetation, ripening and harvesting. The fluctuations in oat yield were conditioned by spring moisture storage, weather conditions of sowing and harvesting but mainly by temperature background of during a period of summer vegetation and crop ripening.
TRENDS AND PRIORITIES IN WATER USE IN THE REPUBLIC OF BELARUS
Authors: Shershnyov O. V.
Published: May 2022

Based on the water management statistics of the state water cadaster, the results of a study of the water use for the period 2000–2019 are presented. Research level covered the country as a whole, regions and administrative districts. The study is based on statistical methods for analyzing time-series and relative indicators of the dynamics of water use. The tendencies and priorities in water use in the administrative-territorial units of the Republic of Belarus are revealed on the basis of a comparative analysis presented in relative terms of indicators: total water abstraction, volume of groundwater extraction and withdrawal of surface water, the amount of water for water use purposes. For the period 2000–2019 downward trends in total water abstraction and water use have been established. The reduction in water abstraction was 28 %, and the use of water for domestic and drinking and industrial purposes decreased by more than 30 %. The largest decrease in water abstraction (from 30 to 40 %) occurred in the Gomel, Mogilev and Vitebsk regions. In the structure of water use among the regions, with the exception of the Brest region, domestic and drinking purposes prevail, which account for up to 33–54 % of water from the total volume of use. A comparative assessment at the level of administrative districts revealed that in most of them (in 102 out of 118 districts), groundwater is the main natural source of water supply. Groundwater abstraction exceeds surface water abstraction. In 36 districts, water supply is provided entirely from groundwater. The administrative districts were grouped according to the priority purposes of water use. It has been established that in 78 districts the priority is simultaneously two purposes of water use, as a rule, domestic and drinking and agricultural purposes, provided by groundwater. Differentiation of water intake volumes and water use priorities at the district level is determined by the population, the degree of development of the production industries, and their purposes of water. A unified record of displaying water use indicators at the level of administrative districts is proposed.
SOLVING THE BINARY CLASSIFICATION TASK FOR THE ASSESSING OF BELOVEZHSKAYA PUSHCHA GROUNDWATERS’ SENSITIVITY TO MODERN CLIMATIC VARIATIONS
Authors: Savich-Shemet O. G.
Published: May 2022

The scientific ideas about the impact of climate changes in recent and coming decades on groundwater accumulated to the present date indicate the absence of a coordinated experts opinion on the sensitivity of groundwater to modern climate changes. The article proposes a method for the determining of the sensitivity of groundwater on the example of the protected area of Belovezhskaya Pushcha to modern climatic variations, justifies the sufficiency of successful verification and validation of the obtained results on its basis.

Based on actual meteorological, hydrological and hydrogeological data characterizing changes in air temperature, precipitation, water and thermal regime on the territory of Belovezhskaya Pushcha, atmospheric cycling, modeling of the sensitivity of groundwater to modern climatic variations was carried out, the task of binary classification of the level regime of groundwater of the Glubonetsky and Kamenyuksky hydrogeological posts was solved.

Objective and subjective uncertainties of estimates of the impact of long-term variations of climatic characteristics on groundwater are considered, the need to continue comprehensive interdisciplinary studies of the relationship between climate change and fresh groundwater is noted.
DEPENDENCE OF STRENGTH CHARACTERISTICS OF MUDSTONE-LIKE CLAYS FROM THE AMOUNT OF UNFROZEN WATER
Authors: Brovka A. G. , Dedyulya I. V. , Murashko A. A.
Published: May 2022

The article presents a methodology for studying of the strength properties of frozen soils using a modernized automated testing complex (AIC "ASIS") produced by NPP "Geotek" LLC (Penza, Russia) and determining the dependence of the amount of unfrozen water in the soil on the temperature using an adiabatic calorimeter. On the samples of mudstone-like clay, it was found that the conditionally instantaneous strength of frozen soils depends non-linearly on the temperature and salt presence in pore solution. The dependences of the conditional instantaneous strength of mudstone – like clay samples on the amount of unfrozen water in these samples are studied. It is established that the strength properties of clay soils at negative temperatures are mainly determined by the total amount of unfrozen water. The genesis of unfrozen water (temperature or the combined effect of temperature and salt concentration in the pore solution) does not matter.
The Hotel Management Students’ Needs on English Online Learning at Politeknik Internasional Bali
Authors: Damayanti Luh Sri
Published: May 2022

During pandemic Covid-19 which was started at the beginning of 2020, the learning process in all levels of education in Indonesia has been shifting to online learning. Politeknik Internasional Bali as one of the vocational higher education institutions has also implemented online learning for all the subjects. English is one of them. Since then, the needs of students in learning are also changed depending on the learning situation. This research was quantitative research aiming at finding out and examining the hotel management students' needs for English online learning at Politeknik Internasional Bali. There were 20 students involved as participants in the research. The researcher used questionnaires to collect the data. The data gained were analyzed using descriptive statistics to find out the percentage of the needs. Based on the analysis, it was found that the students needed online learning that meet these criteria. The hotel management students need online learning that is (1) fun, (2) contains various activities, (3) provides clear instructions, (4) provides team works, (5) provides learning modules, (6) easily accessed, (7) providing interactive learning, and (8) containing various features. The results of this research can be a source for the development of online learning media, in the forms of modules, learning activities, and others that can meet and are suitable for students' needs.