bluuebunny/crossref_metadata_2025 huggingface dataset:
Diversity of lithophytic moss species in karst regions in response to elevation gradients
Authors: Jin Yalin , Wang Xiurong
Published: June 2023

The distribution pattern of species diversity along various elevation gradients reflects the biological and ecological characteristics of species, distribution status and adaptability to the environment. Altitude, a comprehensive ecological factor, affects the spatial distribution of species diversity in plant communities by causing integrated changes in light, temperature, water and soil factors. In Guiyang City, we studied the species diversity of lithophytic mosses and the relationships between species and environmental factors. The results showed that: (1) There were 52 species of bryophytes in 26 genera and 13 families within the study area. The dominant families were Brachytheciaceae, Hypnaceae and Thuidiaceae. The dominant genera were Brachythecium, Hypnum, Eurhynchium, Thuidium, Anomodon and Plagiomnium; The dominant species were Eurohypnum leptothallum, Brachythecium salebrosum, Brachythecium pendulum etc. The number of family species and dominant family genera increased first and then decreased with the increase of altitude, and their distribution in elevation gradient III (1334-1515m) was the largest, with 8 families, 13 genera and 21 species. The elevation gradient I (970-1151m) was the least species distributed, with 5 families, 10 genera and 14 species. The dominant species with the largest number in each elevational gradient were Eurohypnum leptothallum, Brachythecium pendulum, Brachythecium salebrosum and Entodon prorepens; (2) There were five kinds of life forms in different elevation gradients, including Wefts, Turfs, Mat, Pendants and Tail. Among them, wefts and turfs appeared in all elevations, while a small amount of Pendants appeared in the area of elevational gradient I (970-1151m), and the most abundant life form was found in the range of elevational gradient III (1334-1515m); (3) Patrick richness index and Shannon-Wiener diversity index were highly significantly (p<0.01) positively correlated, both of which increased and then decreased with elevation, reaching a maximum at elevation gradient III (1334-1515m); The Simpson dominance index had a highly significant (p<0.01) negative correlation with the Patrick richness index and the Shannon-Wiener diversity index, which showed a decreasing and then increasing trend with increasing altitude; Pielou evenness index showed no discernible trend; (4) β diversity study revealed that while the similarity coefficient tended to decrease with increasing altitude, the species composition of bryophytes increased. The elevation gradient II (1151-1332m) and elevation gradient I (970-1151m) shared the most similarities, whereas elevation gradient III (1515-1694m) and elevation gradient I shared the least similarities (970-1151m). The findings can enrich the theory of the distribution pattern of lithophytic moss species diversity at distinct elevation gradients in karst regions, and serve a scientific and reasonable reference for restoring rocky desertification and protecting biodiversity there.
I can see (myself) clearly now: Exploring the mediating role of self-concept clarity in the association between self-compassion and indicators of well-being
Authors: Coutts Jacob J. , Al-Kire Rosemary L. , Weidler Daniel J.
Published: June 2023

Is there a connection between loving oneself, knowing oneself, and mental well-being? Self-compassion—a construct that consists of self-kindness, acknowledgment of common humanity, and mindfulness—is associated with numerous positive outcomes including indicators of mental well-being. However, little research exists exploring the mechanism(s) by which self-compassion operates to influence these outcomes. It is possible that self-concept clarity, or the extent to which one’s self-beliefs are clearly defined and stable, acts as such a mechanism. In the current study, we explored the mediating role of self-concept clarity in the associations between self-compassion and three indicators of mental well-being: perceived stress, depressive symptomatology, and life satisfaction. Self-compassion was significantly associated with each of the three indicators of well-being. Additionally, self-concept clarity statistically mediated the relationships between self-compassion and depressive symptomatology, perceived stress, and satisfaction with life. The results of this study suggest a potential mechanism by which self-compassion is associated with greater well-being.
Anatomical variations of the equine femur and tibia using statistical shape modeling
Authors: He Hongjia , Banks Scott A. , Biedrzycki Adam H.
Published: June 2023

The objective of this study was to provide an overarching description of the inter-subject variability of the equine femur and tibia morphology using statistical shape modeling. Fifteen femora and fourteen tibiae were used for building the femur and tibia statistical shape models, respectively. Geometric variations in each mode were explained by biometrics measured on ±3 standard deviation instances generated by the shape models. Approximately 95% of shape variations within the population were described by 6 and 3 modes in the femur and tibia shape models, respectively. In the femur shape model, the first mode of variation was scaling, followed by notable variation in the femoral mechanical-anatomical angle and femoral neck angle in mode 2. Orientation of the femoral trochlear tubercle and femoral version angle were described in mode 3 and mode 4, respectively. In the tibia shape model, the main mode of variation was also scaling. In mode 2 and mode 3, the angles of the coronal tibial plateau and the medial and lateral caudal tibial slope were described, showing the lateral caudal tibial slope angle being significantly larger than the medial. The presented femur and tibia shape models with quantified biometrics, such as femoral version angle and posterior tibial slope, could serve as a baseline for future investigations on correlation between the equine stifle morphology and joint disorders due to altered biomechanics, as well as facilitate the development of novel surgical treatment and implant design. By generating instances matching patient-specific femorotibial joint anatomy with radiographs, the shape model could assist virtual surgical planning and provide clinicians with opportunities to practice on 3D printed models.
Online recommenders’ anthropomorphism improves user response to hedonic and benefit-based product appeals through the recommenders’ perceived ability to learn
Authors: Trzebiński Wojciech , Marciniak Beata , Kulczycka Eliza
Published: June 2023

Previous studies reveal the limited effectiveness of benefit-based and hedonic-based product recommendations provided by online recommenders, and recommender anthropomorphism is considered a remedy. This paper aims to investigate the positive effect of anthropomorphism by involving the online recommender’s perceived ability to learn as a mediator. Based on schema congruity theory, perceived benefit/hedonic appeals appropriateness is considered a dependent variable. In Study 1, subtle anthropomorphic cues within an online recommender had a positive effect on perceived benefit-appeals appropriateness through the perceived ability to learn. Study 2 demonstrated the positive relationship between perceived anthropomorphism and perceived hedonic-appeal appropriateness, with the mediating role of the perceived ability to learn. The results advance the knowledge about consumer response to online recommenders from the perspective of anthropomorphism and schema congruity theory. Marketers and consumer organizations are advised on how to deal with online recommender systems providing benefit and hedonic appeals.
Treatment of high-grade glioma patients during the COVID-19 pandemic: Impact on overall survival, tumor size and delay of treatment
Authors: Mischkulnig Mario , Hopp Benjamin , Wadiura Lisa I. , Khalaveh Farjad , Kiesel Barbara , Rössler Karl , Widhalm Georg , Dorfer Christian
Published: June 2023

Background

Throughout the last years, the coronavirus disease 2019 (COVID-19) pandemic posed a major challenge to the optimal and timely treatment of neurooncological patients around the world. While the importance of prompt surgical treatment in high-grade gliomas is widely accepted, there is sparse data on the impact of the pandemic on patients suffering from this malignant disease.

Methods

We performed a retrospective analysis of patients undergoing surgical high-grade glioma treatment at the Medical University of Vienna between March 2020 and February 2021, as well as a control cohort of patients who received treatment between January and December 2019. Time lag between referral for surgical treatment to actual surgery, preoperative tumor volume and overall patient survival were compared between groups.

Results

A total of 118 patients, including 62 cases treated during the first year of the COVID-19 pandemic, as well as 56 control patients, were investigated in this study. Median interval to surgery was significantly shorter in patients treated during COVID-19 compared with the control group (4.00 versus 7.00 days; p = 0.0005). In contrast, patients treated during COVID-19 exhibited marginally larger preoperative tumor volumes, while overall patient survival was comparable between groups.

Conclusions

The COVID-19 pandemic did not negatively affect the overall survival of patients undergoing surgical high-grade glioma treatment at our institution. The significantly shorter treatment delay in patients treated during the pandemic likely reflects increased resource allocation for this critical patient population.
Impact of timing and severity of COVID-19 infection in pregnancy on intrauterine fetal growth- a registry-based study from Qatar
Authors: Farrell Thomas , Minisha Fathima , Abu Yaqoub Salwa , Rahim Abubaker Abdel , Omar Mai , Ahmed Huda , Lindow Stephen , Abraham Merlin Rajam , Gassim Mahmoud , Al-Dewik Nader , Ahmed Shamsa , Al-Rifai Hilal ,   Q-precious group
Published: June 2023

Background

The novel coronavirus disease (COVID-19) pandemic has impacted pregnant women, increasing maternal and neonatal morbidity. The placenta is a potential target for the pathophysiological processes due to the increased thrombotic inflammatory activation and inadequate uteroplacental perfusion and oxygenation, potentially causing intrauterine growth restriction. This study investigates the impact of gestational age at diagnosis of COVID-19 and the presence of symptoms on intrauterine fetal growth in pregnant women.

Methods

A retrospective review of COVID-19 positive pregnant women in Qatar from March 2020 to March 2021 was conducted. They were divided based on trimester of pregnancy in which they were infected. The outcomes included birthweight, customised fetal birthweight centiles, small for gestational age (SGA) baby and daily growth increments, compared between the trimesters and between symptomatic and asymptomatic women.

Results

In our cohort, 218 women (20.5%) were infected in the first trimester, 399 (37.5%) in the second and 446 (42%) in the third. Women in the second trimester were significantly younger and symptomatic. Women infected in the first trimester were least likely to have diabetes. The mean birthweight, risk of SGA (11.5% vs 10% vs 14.6%, p = 0.302), and median customized growth centiles (47.6% vs 45.9% vs 46.1%)were similar between the groups. Symptomatic women had significantly lower mean birthweight (3147 gms vs 3222 gms) and median birthweight centiles (43.9% vs 54.0%)compared to the asymptomatic (p<0.05 for both). In women infected within 20 weeks of gestation, a delay in daily fetal growth increments was noted with symptomatic disease, although not statistically significant.

Conclusion

This study shows that women with symptomatic disease had lower birth centiles and birth weights. This was regardless of the gestational age at which they were infected. Early symptomatic disease seems to have an impact on fetal growth velocity; however, larger studies are needed to corroborate these findings.
Systematic review and theoretical comparison of children’s outcomes in post-separation living arrangements
Authors: Vowels Laura M. , Comolli Chiara L. , Bernardi Laura , Chacón-Mendoza Daniela , Darwiche Joëlle
Published: June 2023

The purpose of the systematic review was to synthesize the literature on children’s outcomes across different living arrangements (nuclear families, shared physical custody [SPC], lone physical custody [LPC]) by extracting and structuring relevant theoretical hypotheses (selection, instability, fewer resources, and stressful mobility) and comparing the empirical findings against these hypotheses. Following the PRISMA guidelines, the review included 39 studies conducted between January 2010-December 2022 and compared the living arrangements across five domains of children’s outcomes: emotional, behavioral, relational, physical, and educational. The results showed that children’s outcomes were the best in nuclear families but in 75% of the studies children in SPC arrangements had equal outcomes. Children in LPC tended to report the worst outcomes. When compared with the different theoretical hypotheses, the results were the most consistent with fewer resources hypothesis which suggests that children especially in LPC families have fewer relational and economic resources whereas children in SPC families are better able to maintain resources from both parents.
High-throughput super-resolution analysis of influenza virus pleomorphism reveals insights into viral spatial organization
Authors: McMahon Andrew , Andrews Rebecca , Groves Danielle , Ghani Sohail V. , Cordes Thorben , Kapanidis Achillefs N. , Robb Nicole C.
Published: June 2023

Many viruses form highly pleomorphic particles. In influenza, virion structure is of interest not only in the context of virus assembly, but also because pleomorphic variations may correlate with infectivity and pathogenicity. We have used fluorescence super-resolution microscopy combined with a rapid automated analysis pipeline, a method well-suited to the study of large numbers of pleomorphic structures, to image many thousands of individual influenza virions; gaining information on their size, morphology and the distribution of membrane-embedded and internal proteins. We observed broad phenotypic variability in filament size, and Fourier transform analysis of super-resolution images demonstrated no generalized common spatial frequency patterning of HA or NA on the virion surface, suggesting a model of virus particle assembly where the release of progeny filaments from cells occurs in a stochastic way. We also showed that viral RNP complexes are located preferentially within Archetti bodies when these were observed at filament ends, suggesting that these structures may play a role in virus transmission. Our approach therefore offers exciting new insights into influenza virus morphology and represents a powerful technique that is easily extendable to the study of pleomorphism in other pathogenic viruses.
Some reflections on Mitchell’s pragmatist variant of scientific realism
Authors: Bertolaso Marta , Sterpetti Fabio
Published: June 2023

This article aims at discussing an interesting variant of scientific realism recently proposed and defended by Sandra Mitchell (forthcoming), namely an affordances-based and pragmatist variant of scientific realism. We firstly place Mitchell’s proposal in the context of the current state of the debate over scientific realism. Secondly, we summarize the salient features of Mitchell’s proposal. Thirdly, we point out some aspects of that proposal that might require some further refinement and clarification in order to make it less prone to criticisms by both realists and antirealists. More precisely, in this paper we address the following issues: 1) whether Mitchell’s proposal can be classified as a genuine form of scientific realism; 2) whether the fact that in Mitchell’s proposal figure some variants of the no miracle argument is in tension with some other of its features.
Perioperative Clinical Features and Long-term Prognosis After Oblique Lateral Interbody Fusion (OLIF), OLIF With Anterolateral Screw Fixation, or OLIF With Percutaneous Pedicle Fixation: A Comprehensive Treatment Strategy for Patients With Lumbar Degenerative Disease
Authors: Zhang Xiangyu , Wang Yutian , Zhang Weikang , Liu Shaocheng , Liu Zhenlei , Wang Kai , Wu Hao
Published: June 2023

Objective: To compare the efficacy of oblique lateral interbody fusion (OLIF), OLIF combined with anterolateral screw fixation (OLIF-AF), and OLIF combined with percutaneous pedicle screw fixation (OLIF-PF) in the treatment of single-level or 2-level degenerative lumbar disease.Methods: Between January 2017 and 2021, 71 patients were treated with OLIF and combined OLIF. The demographic data, clinical outcomes, radiographic outcomes, and complications were compared among the 3 groups.Results: The operative time and intraoperative blood loss in the OLIF (p<0.05) and OLIF-AF (p<0.05) groups were lower than in the OLIF-PF group. Posterior disk height improvement in the OLIF-PF group was better than in the OLIF (p<0.05) and OLIF-AF (p<0.05) groups. In terms of foraminal height (FH), the OLIF-PF group was significantly better than the OLIF group (p<0.05), but there was no significant difference between the OLIF-PF and OLIF-AF groups (p>0.05) or between the OLIF and OLIF-AF groups (p>0.05). There were no significant differences in fusion rates, the incidence of complications, lumbar lordosis, anterior disc height, and cross-sectional area among the 3 groups (p>0.05). The OLIF-PF group had significantly lower rates of subsidence than the OLIF group (p<0.05).Conclusion: OLIF remains a viable option with similar patient-reported outcomes and fusion rates compared with surgeries that include lateral and posterior internal fixation while greatly reducing the financial burden, intraoperative time, and intraoperative blood loss. OLIF has a higher subsidence rate than lateral and posterior internal fixation, but most subsidence is mild and has no adverse effect on clinical and radiographic outcomes.
Cervical Spondylotic Myelopathy: From the World Federation of Neurosurgical Societies (WFNS) to the Italian Neurosurgical Society (SINch) Recommendations
Authors: Costa Francesco , Anania Carla Daniela , Agrillo Umberto , Roberto Assietti , Claudio Bernucci , Simona Bistazzoni , Daniele Bongetta , Carlo Brembilla , Barbara Cappelletto , Ardico Cocciaro , Battista Costella Giovanni , Raffaele De Falco , Andrea De Rosa , Carlo Del Vecchio , Mauro Dobran , Vito Fiorenza , Diego Garbossa , Giancarlo Guizzardi , Corrado Iaccarino , Claudio Irace , Michele Incerti , Innocenzi Gualtiero , Alessandro Landi , Giancarlo Lastrucci , Giuseppe Maida , Ciro Mastrantuoni , Rosario Maugeri , Vincenzo Meglio , Nicola Montemurro , Pierpaolo Nina , Andrea Parlangeli , Giovanni Pinna , Federico Pretti Pier , Armando Rapanà , Alessandro Ricci , Rossella Rispoli , Stefano Romoli , Sbaffi Per Filippo , Teresa Somma , Enrico Tessitore , Matteo Vitali , Zerbi Alberto , Gianluigi Zona , Barbanera Andrea
Published: June 2023

Cervical spondylotic myelopathy (CSM) is a progressively growing pathology to afford by a spinal surgeon due to the aging of the population, associated with better treatment management and the best diagnosis and treatment solutions are greatly discussed. Nowadays that scientific literature is progressively increasing to identify the gold standard in diagnosis and treatment can be very challenging. This is particularly evident in spinal surgery with many different indications not only in different countries but also in the same local reality. In this scenario, many neurosurgical societies works to identify some guideline or recommendations to help spinal surgeons in daily practice. Furthermore, in an era in which legal issues are increasingly present in clinical practice to have some indications globally accepted can be very useful. World Federation of Neurosurgical Societies (WFNS) few years ago starts this process creating a list of recommendations originating from a worldwide steering committee to respect all the local reality. The spinal section of Italian Neurosurgical Society decides to adopt the WFNS recommendations with some revision basing on Italian scenario. The steering committee of the Spinal Section of Italian Neurosurgical Society identify 7 groups to review the literature of the last 10 years about different topics on CSM and to analyses the WFNS recommendations to adapt it to the Italian daily practice. The statements were discussed and voted in 2 sessions to obtain the final version. A list of recommendations on natural course and clinical presentation; diagnostic tests; conservative and surgical treatment; anterior, posterior and combined surgical treatment; role of neurophysiological monitoring and follow-up and outcome was created with only few new or revised statements respect the ones of WFNS. The Spine Section of Italian Neurosurgical Society create a list of recommendations that represent the more contemporary treatment concepts for CSM as presented in the highest quality clinical literature and best clinical practices available on this subject.
Assessment of Cervical Myelopathy Risk in Ossification of the Posterior Longitudinal Ligament Patients With Spinal Cord Compression Based on Segmental Dynamic Versus Static Factors
Authors: He Zhongyuan , Tung Nguyen Tran Canh , Makino Hiroto , Yasuda Taketoshi , Seki Shoji , Suzuki Kayo , Watanabe Kenta , Futakawa Hayato , Kamei Katsuhiko , Kawaguchi Yoshiharu
Published: June 2023

Objective: Using segmental dynamic and static factors, we aimed to elucidate the pathogenesis and relationship between ossification of the posterior longitudinal ligament (OPLL) and the severity of cervical myelopathy.Methods: Retrospective analysis of 163 OPLL patients' 815 segments. Imaging was used to evaluate each segmental space available for the spinal cord (SAC), OPLL diameter, type, bone space, K-line, the C2–7 Cobb angle, each segmental range of motion (ROM), and total ROM. Magnetic resonance imaging was used to evaluate spinal cord signal intensity. Patients were divided into the myelopathy group (M group) and the without myelopathy group (WM group).Results: Minimal SAC (p = 0.043), (C2–7) Cobb angle (p = 0.004), total ROM (p = 0.013), and local ROM (p = 0.022) were evaluated as an independent predictor of myelopathy in OPLL. Different from the previous report, the M group had a straighter whole cervical spine (p < 0.001) and poorer cervical mobility (p < 0.001) compared to the WM group. Total ROM was not always a risk factor for myelopathy, as its impact depended on SAC, when SAC > 5 mm, the incidence rate of myelopathy decreased with the increase of total ROM. Lower cervical spine (C5–6, C6–7) showing increased “Bridge-Formation,” along with spinal canal stenosis and segmental instability (C2–3, C3–4) in the upper cervical spine, could cause myelopathy in M group (p < 0.05).Conclusion: Cervical myelopathy is linked to the OPLL’s narrowest segment and its segmental motion. The hypermobility of the C2–3 and C3–4, contributes significantly to the development of myelopathy in OPLL.
METTL3 Affects Spinal Cord Neuronal Apoptosis by Regulating Bcl-2 m6A Modifications After Spinal Cord Injury
Authors: Guo Shengyu , Lin Taotao , Chen Gang , Shangguan Zhitao , Zhou Linquan , Chen Zhi , Shi Tengbin , Chen Dehui , Wang Zhenyu , Liu Wenge
Published: June 2023

Objective: Spinal cord injury (SCI) is a severe type of neurological trauma. N6-methyladenosine (m6A) modification is one of the most common internal modifications of RNA. The role of METTL3, the predominant methylation enzyme of m6A modification, in SCI remains unclear. This study aimed to investigate the role of methyltransferase METTL3 in SCI.Methods: After establishing the oxygen-glucose deprivation (OGD) model of PC12 cells and rat spinal cord hemisection model, we found that the expression of METTL3 and the overall m6A modification level were significantly increased in neurons. The m6A modification was identified on B-cell lymphoma 2 (Bcl-2) messenger RNA (mRNA) by bioinformatics analysis, and m6A-RNA immunoprecipitation and RNA immunoprecipitation. In addition, METTL3 was blocked by the specific inhibitor STM2457 and gene knockdown, and then apoptosis levels were measured.Results: In different models, we found that the expression of METTL3 and the overall m6A modification level were significantly increased in neurons. After inducing OGD, inhibition of METTL3 activity or expression increased the mRNA and protein levels of Bcl-2, inhibited neuronal apoptosis, and improved neuronal viability in the spinal cord.Conclusion: Inhibition of METTL3 activity or expression can inhibit the apoptosis of spinal cord neurons after SCI through the m6A/Bcl-2 signaling pathway.
Efficacy of Transforaminal Endoscopic Lumbar Discectomy in Elderly Patients Over 65 Years of Age Compared to Young Adults
Authors: Son Seong , Yoo Byung Rhae , Kim Hee Jeong , Song Sung Kyu , Ahn Yong
Published: June 2023

Objective: Spine surgery rates are increasing in the elderly population due to social aging, and it is known that prognoses related to surgery are worse for the elderly compared to younger individuals. However, minimally invasive surgery, such as full endoscopic surgery, is considered safe with low complication rates due to minimal damage to surrounding tissues. In this study, we compared outcomes of transforaminal endoscopic lumbar discectomy (TELD) in elderly and younger patients with disc herniation in the lumbosacral region.Methods: We retrospectively analyzed the data of 249 patients who underwent TELD at a single center between January 2016 to December 2019, with a minimum follow-up of 3 years. Patients were allocated to 2 groups: a young group aged ≤ 65 years (n = 202) or an elderly group aged > 65 years (n = 47). We evaluated baseline characteristics, clinical outcomes, surgery-related outcomes, radiological outcomes, perioperative complications, and adverse events during the 3-year follow-up period.Results: Baseline characteristics, including age, general condition based on American Society of Anesthesiologist physical status classification grade, age-Charlson Comorbidity Index, and disc degeneration, were worse in elderly group (p < 0.001). However, except for leg pain at 4 weeks after surgery, overall outcomes, including pain improvement, radiological change, operation time, blood loss, and hospital stay, were not different between the 2 groups. Furthermore, the rates of perioperative complications (9 patients [4.46%] in the young group and 3 patients [6.38%] in the elderly group, p = 0.578) and adverse events over the 3-year follow-up period (32 patients [15.84%] in the young group and 9 patients [19.15%] in the elderly group, p = 0.582) were comparable in the 2 groups.Conclusion: Our findings suggest that TELD produces similar outcomes in both elderly and younger patients with a herniated disc in the lumbosacral region. TELD can be considered a safe option for appropriately selected elderly patients.
Three-Dimensional-Printed Titanium Versus Polyetheretherketone Cages for Lumbar Interbody Fusion: A Systematic Review of Comparative In Vitro, Animal, and Human Studies
Authors: Patel Neal A. , O’Bryant Sinead , Rogers Christopher D. , Boyett Candler K. , Chakravarti Sachiv , Gendreau Julian , Brown Nolan J. , Pennington Zach A. , Hatcher Neill B. , Kuo Cathleen , Diaz-Aguilar Luis Daniel , Pham Martin H.
Published: June 2023

Interbody fusion is a workhorse technique in lumbar spine surgery that facilities indirect decompression, sagittal plane realignment, and successful bony fusion. The 2 most commonly employed cage materials are titanium (Ti) alloy and polyetheretherketone (PEEK). While Ti alloy implants have superior osteoinductive properties they more poorly match the biomechanical properties of cancellous bones. Newly developed 3-dimensional (3D)-printed porous titanium (3D-pTi) address this disadvantage and are proposed as a new standard for lumbar interbody fusion (LIF) devices. In the present study, the literature directly comparing 3D-pTi and PEEK interbody devices is systematically reviewed with a focus on fusion outcomes and subsidence rates reported in the in vitro, animal, and human literature. A systematic review directly comparing outcomes of PEEK and 3D-pTi interbody spinal cages was performed. PubMed, Embase, and Cochrane Library databases were searched according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) guidelines. Mean Newcastle-Ottawa Scale score for cohort studies was 6.4. A total of 7 eligible studies were included, comprising a combination of clinical series, ovine animal data, and in vitro biomechanical studies. There was a total population of 299 human and 59 ovine subjects, with 134 human (44.8%) and 38 (64.4%) ovine models implanted with 3D-pTi cages. Of the 7 studies, 6 reported overall outcomes in favor of 3D-pTi compared to PEEK, including subsidence and osseointegration, while 1 study reported neutral outcomes for device related revision and reoperation rate. Though limited data are available, the current literature supports 3D-pTi interbodies as offering superior fusion outcomes relative to PEEK interbodies for LIF without increasing subsidence or reoperation risk. Histologic evidence suggests 3D-Ti to have superior osteoinductive properties that may underlie these superior outcomes, but additional clinical investigation is merited.
Vertebral Body Sliding Osteotomy as a Surgical Strategy for the Treatment of Cervical Myelopathy: Complications and Pitfalls
Authors: Lee Dong-Ho , Cho Sung Tan , Park Sehan , Hwang Chang Ju , Cho Jae Hwan , Kim Jin Hwan
Published: June 2023

Objective: This retrospective cohort study has been aimed at evaluating the incidence of complications after vertebral body sliding osteotomy (VBSO) and analyzing some cases. Furthermore, the complications of VBSO were compared with those of anterior cervical corpectomy and fusion (ACCF).Methods: This study included 154 patients who underwent VBSO (n = 109) or ACCF (n = 45) for cervical myelopathy and were followed up for > 2 years. Surgical complications, clinical and radiological outcomes were analyzed.Results: The most common surgical complications after VBSO were dysphagia (n = 8, 7.3%) and significant subsidence (n = 6, 5.5%). There were 5 cases of C5 palsy (4.6%), followed by dysphonia (n = 4, 3.7%), implant failure (n = 3, 2.8%), pseudoarthrosis (n = 3, 2.8%), dural tears (n = 2, 1.8%), and reoperation (n = 2, 1.8%). C5 palsy and dysphagia did not require additional treatment and spontaneously resolved. The rates of reoperation (VBSO, 1.8%; ACCF, 11.1%; p = 0.02) and subsidence (VBSO, 5.5%; ACCF, 40%; p < 0.01) were significantly lower in VBSO than in ACCF. VBSO restored more C2–7 lordosis (VBSO, 13.9° ± 7.5°; ACCF, 10.1° ± 8.0°; p = 0.02) and segmental lordosis (VBSO, 15.7° ± 7.1°; ACCF, 6.6° ± 10.2°; p < 0.01) than ACCF. The clinical outcomes did not significantly differ between both groups.Conclusion: VBSO has advantages over ACCF in terms of low rate of surgical complications related to reoperation and significant subsidence. However, dural tears may still occur despite the lessened need for ossified posterior longitudinal ligament lesion manipulation in VBSO; hence, caution is warranted.
Proteomic Comparison of Paraspinal Muscle Imbalance Between Idiopathic Scoliosis and Congenital Scoliosis
Authors: Wang Zhen , Huang Xu’an , Tan Haining , Liang Jinqian , Li Zheng , Shen Jianxiong
Published: June 2023

Objective: This study aims to compare the proteomic profiles of paraspinal muscle imbalance between idiopathic scoliosis (IS) and congenital scoliosis (CS).Methods: Bilateral paraspinal muscles of 5 pairs of matched IS and CS patients were collected. Proteome patterns of paraspinal muscles were established. Differentially expressed proteins (DEPs) in paraspinal muscles between the convexity and the concavity were screened out. DEPs shared by both IS and CS and IS-specific DEPs were identified. Bioinformatic analyses of DEPs were performed.Results: Among 105 DEPs identified in IS, 30 displayed predominant expression on the convexity, whereas other 75 exhibited predominant expression on the concavity. DEPs in IS were mainly enriched in calcium ion binding and DNA binding in gene ontology (GO) term and glycolysis/gluconeogenesis and purine metabolism in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway. Among 48 DEPs identified in CS, 25 were predominantly expressed on the convexity and 23 on the concavity. DEPs in CS were mainly enriched in receptor activity and immune response in GO term and glycolysis/gluconeogenesis and cellular senescence in KEGG pathway. Comparison of DEPs between IS and CS identified only 8 proteins shared by both types of scoliosis. Among the 97 IS-specific DEPs, 28 were predominantly expressed on the convexity and 69 on the concavity. IS-specific genes were enriched in calcium ion binding and protein glycosylation in GO term and glycolysis/gluconeogenesis and hypertrophic cardiomyopathy in KEGG pathway.Conclusion: IS and CS exhibit proteomic imbalance in bilateral paraspinal muscles but share few similarities. Paraspinal muscle imbalance in IS might not be the consequence of spinal deformities.
From the Spinopelvic Parameters to Global Alignment and Proportion Scores in Adult Spinal Deformity
Authors: Cho Yongjae , Jo Dae Jean , Hyun Seung-Jae , Park Jin Hoon , Yang Na Rae
Published: June 2023

In the last 20 years, sagittal alignment and balance of the spine have become one of the most important issues in the field of spine surgery. Recent studies emphasize that sagittal balance and alignment are more important for health-related quality of life. The understanding of normal and abnormal sagittal alignment of the spine is necessary for the diagnosis and appropriate treatment of adult spinal deformity (ASD), and we will discuss the currently used classification of ASD, the parameters of sagittal alignment that are essential for the diagnosis of spinal deformity, compensatory actions to maintain sagittal balance, and the relationship between sagittal alignment and clinical symptoms. Furthermore, we will also discuss the recently introduced Global Alignment and Proportion scores. The Korean Spinal Deformity Society is publishing a series of review articles on spinal deformities to help spine surgeons better understand spinal deformities.
A conversação dos usuários da marca Nubank no Twitter a partir da Hashtag #VEMPRONUBANKPADRE
Authors: Sanchotene Carlos Renan Samuel , Faria Lucas Vilela de
Published: June 2023

O presente artigo busca compreender como é formada a rede de conversação entre os usuários da marca Nubank no Twitter. Entre os objetivos busca-se estudar o compartilhamento de hashtags da marca identificando as métricas de engajamento que se baseiam nas seguintes categorias: voz dominante, preocupação, comprometimento, posicionamento e alinhamento. A metodologia foi elaborada a partir da Análise Crítica (ROGERS, 2018) do engajamento nas redes sociais digitais. Para tanto, foi analisada a hashtag #VemProNubankPadre criada no dia 22 de maio de 2019. Conclui-se que a empresa Nubank cria situações em que seus seguidores podem interagir de forma descontraída preocupando-se em manter um atendimento humanizado e íntimo com o consumidor.
Diagnostic imaging findings of subcutaneous mast cell tumor in a dog
Authors: Kwon Sojeong , Jang Min , Lee Sang-Kwon , Lee Kija
Published: June 2023

A 5-year-old Labrador Retriever presented with a subcutaneous mass on the right scapular region with localized calor. On magnetic resonance imaging (MRI), a heterogeneously hypointense mass was seen on T1-weighted images (WI) and hyperintense on T2WI and fat-suppressed T2WI with marginal contrast enhancement on postcontrast T1WI and invasion into the surrounding tissue. Histopathological examination of the mass confirmed subcutaneous mast cell tumor (MCT) infiltrating to the adjacent subcutaneous fat. This is the first report to describe the MRI findings of subcutaneous MCT in veterinary medicine. This study suggests that MRI may help evaluate the extent of invasion of subcutaneous MCT.
Effect of resynchronization programs according to the ovarian status on pregnancy outcomes in dairy cows
Authors: Jeong Jaekwan , Kim Uihyung , Kim Illhwa
Published: June 2023

This study evaluated the effect of resynchronization programs on pregnancies in dairy cows. Of 1,342 cows confirmed not pregnant after their first artificial insemination (AI), those with a corpus luteum (CL) were resynchronized using Ovsynch or PG-GnRH-Ovsynch and those without a CL were resynchronized using GnRH-Ovsynch or modified Double-Ovsynch. There were no differences (p > 0.05) in the pregnancies per AI either between the Ovsynch (31.3%) and PG-GnRH-Ovsynch (34.0%) or between the GnRH-Ovsynch (38.7%) and modified Double-Ovsynch (39.5%). In conclusion, Ovsynch and GnRH-Ovsynch programs could be preferred to resynchronize cows with and without a CL, respectively, from the perspective of reducing costs and labor.
Small intestinal epiploic foramen entrapment in a seven-month pregnant Thoroughbred mare: a case report
Authors: Hwang Hyebin , Lee Seyoung , Park Kyung-won , Lee Eun-bee , Kang Taeyoung , Seo Jong-pil , Jeong Hyohoon
Published: June 2023

A seven-month pregnant four-year-old Thoroughbred mare with colic weighing 600 kg was referred to the Jeju National University Equine Hospital. A physical examination and ultrasound suggested epiploic foramen entrapment. The patient underwent ileum resection and end-to-side jejunocecostomy. After surgery, the horse showed a consistent pain when introduced to feeding. A repeat laparotomy was performed to enlarge the stoma size with side-to-side jejunocecostomy. The repeat laparotomy was successful, and the mare gave birth uneventfully. This report describes a case of small intestinal epiploic foramen entrapment and the clinical outcomes of the 2 consecutive laparotomies a Thoroughbred mare in late gestation.
Treatment of descemetocele with deep keratotomy combined with a nictitating membrane flap in a dog
Authors: Jeong Manbok
Published: June 2023

A 10-year-old, spayed female, Maltese dog presented with a 2-day history of severe left eye squint. Slit-lamp biomicroscopy showed a deep corneal defect stained into a doughnut shape together with hypopyon in the anterior chamber. Based on these results, a diagnosis of descemetocele and uveitis in the left eye was made. Deep keratotomy combined with a nictitating membrane flap effectively resolved the descemetocele without complications. The surgical procedures performed on this patient were easy and effective, and could be used as an alternative to graft surgery for descemetocele treatment.
Experimental infection of a porcine kidney cell line with hepatitis A virus
Authors: Kim Dong-Hwi , Kim Da-Yoon , Kim Jae-Hyeong , Lim Kyu-Beom , Lee Joong-Bok , Park Seung-Yong , Song Chang-Seon , Lee Sang-Won , Choi In-Soo
Published: June 2023

The hepatitis A virus (HAV) induces severe acute liver injury and is adapted to human and monkey cell lines but not other cells. In this study, the HAV was inoculated into porcine kidney (PK-15) cells to determine its infectivity in porcine cells. The growth pattern of the HAV in PK-15 cells was compared with its growth pattern in fetal rhesus kidney (FRhK-4) cells. The growth of HAV was less efficient in PK-15 cells. In conclusion, HAV replication was verified in PK-15 cells for the first time. Further investigations will be needed to identify the HAV-restrictive mechanisms in PK-15 cells.
KEHIDUPAN MEMBIARA DAN JEBAKAN TAKDIR: SUBJEKTIVITAS ROMO YB MANGUNWIJAYA DALAM PERSPEKTIF SLAVOJ ŽIŽEK
Authors: Taum Yoseph Yapi
Published: June 2023

The monastic life for celibate individuals is not a problem-free life choice. As human beings, individuals who choose the monastic life face various biological, sociological, and psychological upheavals that are not easily overcome. These upheavals can lead to a crisis of faith. This study aims to uncover the issues faced by celibate individuals as depicted in the novel "Romo Rahardi" by YB Mangunwijaya. The study will employ Slavoj Žižek's symbolic discursive theory to unravel the symbolic entanglements that constrain the subjects and reveal the characters' positions in confronting their lives as celibate individuals. This research is a qualitative descriptive study that utilizes a discursive approach. The findings of this research reveal fractures and disorientation in the subjective realm. When Rahadi reaches the age of puberty, he becomes aware of the extraordinary sexual attraction towards the opposite sex, and he views this phenomenon as something good, natural, and positive. However, this awareness becomes a tremendous black hole as Rahadi enters the symbolic order. The celibate lifestyle confines him without the opportunity to explore alternative paths. In the real realm, when Rahadi reflects on the reality of his life as a spiritual person, he discovers a fragmented and incomplete subjective condition that is far from ideal—a primordial and absurd alienation. There exists a homology between Romo Rahadi and Romo YB Mangunwijaya.
The Minority and the State: Chinese Muslims in the Modern History of Indonesia
Authors: Ubaedillah Achmad
Published: June 2023

Despite their long existence in Nusantara, the Chinese ethnic groups remain less represented or even misrepresented in the history of Indonesia, resulting in negative stereotypes and attitudes towards the community. Sejarah Nasional Indonesia (SNI) and history textbooks for schools and universities, for instance, do not provide adequate narratives about Chinese contributions to Indonesian politics and economy during the pre- and post-independence era. This study aims to critically analyse the representation of Chinese ethnicities in the modern history of Indonesia, more specifically, the SNI and history textbooks for Islamic schools and universities. The findings of the study suggest that there was an unwritten history of Chinese and Chinese Muslims, especially during the Sukarno and Suharto regimes, which then Abdurrahman Wahid began to include. The study recommends new narratives of Chinese Muslims in modern Indonesian history by proposing some notable scholars who extensively worked on the History of Islam in Java, to which Chinese Muslims had contributed. [Kendati sudah berada di Indonesia berabad-abad lamanya, etnis Tionghoa tidak banyak tercatat dalam narasi sejarah Indonesia. Misrepresentasi etnis Tionghoa di Nusantara bahkan menyebabkan adanya stereotip dan sikap negatif terhadap etnis tersebut. Sejarah Nasional Indonesia (SNI) dan buku teks sejarah di sekolah dan universitas, misalnya, tidak banyak menyebutkan kontribusi etnis Tionghoa secara politik maupun ekonomi selama masa pra dan pasca kemerdekaan. Studi ini merupakan analisis kritis terhadap representasi etnis Tionghoa dalam sejarah modern Indonesia, khususnya dalam Sejarah Nasional Indonesia (SNI) dan buku teks sejarah di sekolah dan kampus Islam. Temuan kajian menunjukkan adanya sejarah yang tidak tercatat tentang peran Muslim Tionghoa selama rezim Sukarno dan Suharto, yang kemudian mulai diubah oleh rezim Gus Dur. Studi ini merekomendasikan adanya penulisan ulang sejarah Muslim Tionghoa di Indonesia dengan mengintegrasikan temuan studi beberapa sarjana ternama yang banyak meneliti mengenai Islam di Jawa dan peran etnis Tionghoa di dalamnya.]
Análisis de la postura de profesionales de la salud frente a la Ley Moral Natural
Authors: Cantú-Quintanilla Guillermo , Farías-Yapur Anneke , Aguiñaga Chiñas Nuria
Published: June 2023

La formación ética de los profesionales de la salud es esencial, especialmente en la cultura posmoderna en la que se descuida la dignidad humana. Según Kant, la dignidad se basa en la autonomía como capacidad de legislar para garantizar la autodeterminación. El enfoque secular de la dignidad permite establecer pautas normativas, complementándose con la Ley Natural. Algunos profesionales consideran que la Ley Moral Natural ofrece un marco sólido para la bioética. El estudio buscó investigar la prevalencia de profesionales que se adhieren a la Ley Moral Natural y desarrollar una escala para medir el nivel de acuerdo con ella. Se realizó un estudio transversal con profesionales de la salud. Se realizó un análisis de frecuencias de 65 cuestionarios. Los resultados mostraron que la mayoría de los participantes se ubicaron en una postura moderada, sin aceptar completamente el relativismo moral. En general, los participantes reconocieron la importancia de la ética en su comportamiento y toma de decisiones. Se encontró que la Ley Moral Natural permite matizar la práctica clínica, guiándola hacia el respeto de la dignidad humana y permitiendo posturas intermedias hacia el relativismo moral. Se confirmó la existencia de absolutos morales y el deseo de justicia y respeto mutuo. Además, se destacó la importancia de la reflexión ética en la ciencia para evitar el deterioro humano..
Economic Situation in the Far Eastern Federal District in 2022
Authors:   Economic Research Institute FEB RAS, Prokapalo Olga , Bardal Anna ,   Economic Research Institute FEB RAS, Isaev Artyom ,   Economic Research Institute FEB RAS, Mazitova Marina ,   Economic Research Institute FEB RAS
Published: June 2023

The socio-economic situation in the Far Eastern Federal District in 2022 is analyzed by main types of economic activity and territorial administrative regions on the basis of operative statistical, analytical and expert information. The paper considers the problems of functioning of the real sector of the economy, social sphere, foreign economic activity in conditions of aggravation of the geopolitical situation and imposition of sanctions. The positive dynamics of investment activity was noted, but its growth rate was lower than the level of 2021. The main volume of investment resources is still accumulated in the Republic of Sakha (Yakutia) and the Amur Oblast, where the implementation of major investment projects in the field of mining, transport, gas chemistry and energy continue. The decline in industrial output in the Far Eastern Federal District was caused by a drop in mining, especially in the Sakhalin Oblast, and a decline in the manufacturing sector. The construction sector of the Far Eastern Federal District demonstrated positive dynamics, connected, among other things, with the expansion of housing construction. But high rates of housing construction in the regions of the Far Eastern Federal District cannot yet compensate for the chronic lag in housing commissioning per capita compared with the average Russian parameters. The transport complex of the Far Eastern Federal District has faced an increase in demand for transportation of foreign trade goods. This aggravated competition for access to the export-import infrastructure (railroads, seaports) with limited carrying capacity, increased shippers’ costs and uncertainty of transportation conditions. The negative impact of various restrictive measures did not affect the structure of Far Eastern Federal District foreign trade. A decrease in the physical volume of exports of fuel and energy products was leveled out by high world prices for energy resources. A decrease in economic activity was substantially influenced by a contraction of the domestic demand against the background of a decline in the population’s real income. The decline in the population, both due to natural decrease and migration outflow, remains an acute problem