bluuebunny/crossref_metadata_2025 huggingface dataset:
The hidden city of immigrants in Helsinki's urban leftovers – the homogenization of the city and the lost diversity
Authors: Hewidy Hossam
Published: December 2022

Cities acknowledge the diversity of their population and consider the multicultural component a richness of their socio-cultural assets. Immigrants contribute to the reshaping of urban space in many European cities through their amenities. Such amenities, be they secular or spiritual, are a clear spatialization of multiculturalism. Ethnic retail is an emerging phenomenon in Helsinki, and it has increasingly replaced declining independent mainstream retail. Often, clusters of immigrant amenities are formed around Muslim prayer rooms activating a mosque-bazaar alliance that enjoys a dynamic footfall. Such a setting takes place spontaneously and typically at abandoned spaces, called in this dissertation urban leftovers. The leftovers are located in, or nearby, the neighbourhoods with a relative overrepresentation of immigrant population. However, these neighbourhoods are exposed to urban renewal steered by anti-segregation policy, thus facing the threat of erasure.
This dissertation examines the capacity of urban planning to plan for diversity. It further studies the characteristics that ethnic retail requires to survive and emerge. The paradigm of The Right to the City is deployed to interpret the response of urban planning to multiculturalism. The findings are numerous. First, immigrant amenities prove their capability to play a role in place making and act as catalysts for public life recovery. Second, in doing so the created places not only fulfil the socio-cultural needs of immigrants, but they also attract mainstream clientele. Third, spontaneity, improvisation and authenticity are the main characteristics empowering the emergence of ethnic retail. However, the findings also show a failure of urban planning to reflect multiculturalism in the growth of the city. Often, the retail premises used by immigrants are demolished. Furthermore, conventional planning as well as alternative planning methods, such as scenario planning and urban planning competitions, have failed to reflect immigrants in the development.
The main constraint preventing planning from being multicultural is the absence of a political interest and, accordingly, a clear vision to deal with the spatialization of multiculturalism. On the contrary, the clear vision of the city is its anti-segregation policy, which is by nature a homogenizing mechanism. Thus, the dissertation concludes that immigrants' Right to the City has been ignored.
Perceived Stress as an Indicator of Work–Family Conflict and Burnout Among Secondary School Athletic Trainers
Authors: Cairns Alexandrya H. , Singe Stephanie M. , Eason Christianne M.
Published: December 2022

Burnout and work–family conflict (WFC) are stressors faced by secondary school athletic trainers, however, the concept of perceived stress and its relationship to burnout or WFC is not well understood. The purpose of this study was to investigate perceived stress’ relationship with burnout and WFC. Participants reported a WFC score of 40.36 (±15.63), low burnout (40.1 ± 16.28), and moderate stress (15.99 ± 7.02). Perceived stress predicted WFC, but not burnout (b = 1.13, t572 = 14.132, p ≤ .001). One’s level of perceived stress impacts WFC, which indicates higher stress will equal greater work–family conflict.
Effects of Plyometric Training Direction on Physical Performance in Basketball Players
Authors: Aztarain-Cardiel Kike , López-Laval Isaac , Marco-Contreras Luis A. , Sánchez-Sabaté Jorge , Garatachea Nuria , Pareja-Blanco Fernando
Published: December 2022

Purpose: The aim of this study was to analyze the effects of plyometric training direction on jumping, sprinting, and change-of-direction ability in basketball players. Methods: Forty male basketball players (21.8 [3.8] y), from 4 teams that competed in regional and national championships, were randomly assigned to 1 of 4 groups: (1) vertical jump group, (2) horizontal jump group, (3) vertical and horizontal jump group, and (4) control group. The subjects followed a plyometric training program twice a week for 6 weeks, differing in the execution direction of the jumps. All groups performed the same total training volume of acyclic and cyclic jumps controlled through the number of contacts per session. Pretraining and posttraining measurements included (1) rocket jump, (2) Abalakov jump, (3) horizontal jump, (4) 20-m linear sprint, and (5) V-Cut change-of-direction test. Results: The vertical and horizontal jump group showed significant increases in all performance variables examined, except for linear sprint performance, in which no group improved. The vertical jump group showed significant improvements in rocket jump and Abalakov jump (P < .01), but worsened significantly in terms of sprint performance (P < .05). The horizontal jump group showed significant increases in rocket jump and horizontal jump (P < .001–.01). Furthermore, all experimental groups showed improved V-Cut change-of-direction test performance. Conclusions: These results indicate that combining vertical and horizontal jumps induces improvements in more capabilities than does training only vertical or horizontal jumps with the same training volume. Training only vertical or horizontal jumps will improve performance mainly in vertically or horizontally oriented tasks, respectively.
Exogenous Caffeine Ingestion Does Not Increase Plantarflexor Torque in Older or Younger Men
Authors: Ugliara Lucas , Bottaro Martim , Alex Sávio , Tufano James J. , Blazevich Anthony J. , Junior Valdinar , Vieira Amilton
Published: December 2022

Aging is associated with neurodegeneration and a loss of muscle function, especially in lower-limb muscles. While caffeine may augment muscle force generation through multiple effects on the central nervous system, no studies have yet compared the effects of caffeine on force-generating capacity between younger and older men, who might respond differently due to age-related changes in the structures on which caffeine acts. In a double-blind, controlled trial, 22 younger (25 ± 5 years) and 21 older (68 ± 6 years) men were tested for isometric plantarflexor torque on two separate days (2–7 days apart) before and 60 min after ingesting 3 mg/kg (∼2 cups of coffee) of caffeine or placebo. No effects of caffeine ingestion on peak torque or rate of torque development were detected in either older or younger men. Therefore, 3 mg/kg of caffeine may not acutely counteract age-related decreases in force capacity of the functionally important plantarflexor muscles.
Perceptions of COVID-19 among communities of Conakry (Guinea): a qualitative study exploring the context of the ANRS COV33 Coverage-Africa therapeutic trial
Authors: Doucet Marie-Hélène , Songbono Christine Timbo , Plazy Mélanie , Martin Caroline , Fritzell Camille , Sow Mamadou Saliou , Traoré Fodé Amara , Jaspard Marie , Poda Armel , Malvy Denis , Marcy Olivier , Delamou Alexandre , Orne-Gliemann Joanna
Published: December 2022

Objectives

To explore communities’ perceptions about COVID-19 in the context of the ANRS COV33 Coverage-Africa clinical trial evaluating the efficacy of treatments in preventing clinical worsening of COVID-19.

Design

Descriptive qualitative study using semistructured in-depth individual interviews conducted by telephone in French and Soussou between May and September 2021. Data were transcribed, translated in French when applicable and analysed with the thematic analysis method.

Setting

The eight neighbourhoods most affected by COVID-19 in Conakry’s urban context, capital of Guinea.

Participants

4 community leaders acting as key informants—providing insights regarding population’s opinions—and six community members, who were exposed to an information session conducted as part of Coverage-Africa.

Results

According to participants, community members have heterogeneous viewpoints about COVID-19: it exists and is dangerous; it is benign (‘bad cold’); or it is fictitious (eg, government conspiracy). The fear of stigmatisation and social isolation of those sick or cured of COVID-19 was largely reported by participants, with illustrations of distressing situations for the victims. To avoid stigma, many patients seem to adopt strategies of discretion (eg, lying/hiding about the disease). Although community attitudes were reported to have evolved since the beginning of the epidemic, stigma remained a pervasive concern for many people.

Conclusions

Community perceptions about COVID-19 in Conakry may be partly explained by the Guinean context of Ebola history and of sociopolitical tensions. Stigmatisation of COVID+ people seems to be aimed at protecting others against contamination. However, social avoidance can greatly affect the morale of stigmatised people, especially in collectivist cultures like Guinea. Further investigating stigma, including its role on seeking COVID-19 screening and treatment services, and its consequences on mental health among affected/exposed people, would contribute to identifying improved prevention and care interventions in preparation for future health threats, and to promoting participation in health research.

Trial registration number

NCT04920838(Pre-results stage).
Removal of mango-flavoured Juul pods created opportunity for adulterated mango Juul-compatible pods with altered chemical constituents
Authors: Dell Liam G , Page Michelle K , Leigh Noel J , Goniewicz Maciej Lukasz
Published: December 2022

Introduction

Juul is a leading electronic cigarette (e-cigarette) brand in the USA. By November 2019, Juul pre-emptively limited online and in-store sales of non-tobacco or menthol-flavoured pods ahead of impending flavour bans. Since this removal, sale of mango-flavoured Juul-compatible pods was introduced to the market by smaller companies. The aim of this study was to compare chemical constituents of original Juul mango pods with mango-flavoured Juul-compatible pods.

Methods

Juul and 16 brands of Juul-compatible mango-flavoured pods were purchased online in May 2018 (original Juul) and November 2019 (Juul-compatible), after Juul voluntarily removed their flavoured pods from the market. Liquid was extracted from pods and analysed using chromatography and mass spectrometry methods for nicotine concentration, solvent ratios, nicotine salt identification, as well as flavouring identification and quantitation.

Results

Juul-compatible pods had a significantly lower average nicotine concentration compared with original Juul pod (42.8±8.9 vs 57.2±0.9 mg/mL, p<0.0001). Nicotine benzoate was used in original Juul pod and all Juul-compatible pods. The propylene glycol to vegetable glycerin volumetric ratio of Juul-compatible pods averaged 55:45, while the original Juul pod was 35:65 (p<0.0001). Total number of flavouring chemicals detected was significantly higher in Juul-compatible pods as compared with Juul (p<0.0001). In Juul-compatible pods, average concentrations of benzyl alcohol (fruity flavouring) were 0.8±1.3 mg/mL, approximately 27 times higher than in original Juul pod (p<0.0001).

Conclusions

Adulterated Juul-compatible products may expose e-cigarette consumers to more chemical constituents at higher concentrations than previously found in the original product, despite similarity in product design.
Associations between living in localities with e-cigarette sales restrictions and e-cigarette use change among young adults in Los Angeles County
Authors: Chen-Sankey Julia , Cruz-Cano Raul , Pakdaman Sheila , Wong Nicholas , Unger Jennifer B , Barrington-Trimis Jessica , Pentz Mary Ann
Published: December 2022

Introduction

Local e-cigarette sales restrictions (ESRs) may impact e-cigarette use. This study examined the associations between living in localities with various ESR policies and changes in e-cigarette use among young adults in Los Angeles (LA) County, California, USA.

Methods

Data were from a cohort of LA County young adults (18–21 years; n=2100) who completed two waves of surveys (Fall 2018–Summer 2019 and Summer–Fall 2020). Local flavoured (n=9) and comprehensive (n=2) ESRs in LA County implemented between June 2019 and May 2020 were identified, coded and merged with the baseline data. Multivariable logistic regressions were used to examine the associations between living in ESR localities and e-cigarette use at follow-up, controlling for covariates and stratified by cigarette smoking at baseline.

Results

Overall, 20.9% and 14.3% of participants lived in localities with flavoured and comprehensive ESRs, respectively. Participants who were non-Hispanic, had higher socioeconomic statuses and were currently using e-cigarettes were generally more likely to live in ESR localities than their counterparts. The associations between living in ESR localities and e-cigarette use at follow-up were not found among baseline non-e-cigarette users regardless of their cigarette smoking status; a positive relationship was found among baseline e-cigarette users who also smoked cigarettes but not among non-smokers.

Discussion

Participants who lived in localities with various ESR policies were different in their baseline e-cigarette use and socioeconomic backgrounds. Future research examining the potential impact of ESRs on e-cigarette use change should consider the localities’ overall sociodemographic and tobacco-using characteristics and individuals’ cigarette smoking histories.
Ethyl maltol, vanillin, corylone and other conventional confectionery-related flavour chemicals dominate in some e-cigarette liquids labelled ‘tobacco’ flavoured
Authors: Omaiye Esther E , Luo Wentai , McWhirter Kevin J , Pankow James F , Talbot Prue
Published: December 2022

Background

The increased popularity of electronic cigarettes (e-cigarettes) has been linked to the abundance of flavoured products that are attractive to adolescents and young adults. In the last decade, e-cigarette designs have evolved through four generations that include modifications in battery power, e-cigarette liquid (e-liquid) reservoirs and atomiser units. E-liquids have likewise evolved in terms of solvent use/ratios, concentration and number of flavour chemicals, use of nicotine salts and acids, the recent increased use of synthetic cooling agents and the introduction of synthetic nicotine. Our current objective was to evaluate and compare the evolving composition of tobacco-flavoured e-liquids over the last 10 years.

Methods

Our extensive database of flavour chemicals in e-liquids was used to identify trends and changes in flavour chemical composition and concentrations.

Results

Tobacco-flavoured products purchased in 2010 and 2011 generally had very few flavour chemicals, and their concentrations were generally very low. In tobacco-flavoured refill fluids purchased in 2019 and Puff Bar Tobacco e-cigarettes, the total number and concentration of flavour chemicals were higher than expected. Products with total flavour chemicals >10 mg/mL contained one to five dominant flavour chemicals (>1 mg/mL). The most frequently used flavour chemicals in tobacco e-liquids were fruity and caramellic.

Conclusions

There is a need for continuous surveillance of e-liquids, which are evolving in often subtle and harmful ways. Chemical constituents of tobacco flavours should be monitored as they clearly can be doctored by manufacturers to have a taste that would appeal to young users.
Polarized images of synchrotron radiations in curved spacetime
Authors: Hu Zezhou , Hou Yehui , Yan Haopeng , Guo Minyong , Chen Bin
Published: December 2022

In this work, we derive two formulas encoding the polarization direction and luminosity of synchrotron radiations from the moving electrons in curved spacetime under the geometric optics approximation. As an application, we further study the polarized images of synchrotron radiations from electron sources in Schwarzschild black hole spacetime with a vertical and uniform magnetic field. In particular, by focusing on the circular orbits of electrons on the equatorial plane, we show the polarized images of the synchrotron radiations from these orbits for different observational angles and discuss the variations of the polarization directions concerning the angles.
Directed Tree Connectivity of Symmetric Digraphs and Complete Bipartite Digraphs
Authors: Yu Junran
Published: December 2022

Sun and Yeo introduced the concept of directed tree connectivity, including the generalized [Formula: see text]-vertex-strong connectivity, [Formula: see text] and generalized [Formula: see text]-arc-strong connectivity, [Formula: see text] [Formula: see text], which could be seen as a generalization of classical connectivity of digraphs and a natural extension of the well-established undirected tree connectivity. In this paper, we study the directed tree connectivity of symmetric digraphs and complete bipartite digraphs. We give lower bounds for the two parameters [Formula: see text] and [Formula: see text] on symmetric digraphs. We also determine the precise values of [Formula: see text] for every [Formula: see text] and [Formula: see text] for [Formula: see text], where [Formula: see text] is a complete bipartite digraph of order [Formula: see text].
Reliability and validity of the Hindi version of international physical activity questionnaire-long-form (IPAQ-LF)
Authors: Prabhu Sukhada S. , Thakur Anuprita M.
Published: December 2022

Background: IPAQ-LF is a widely used tool for subjective assessment of physical activity. It has been translated, cross-culturally adapted into many languages and tested in many countries around the world. However, no Hindi version of the long-form of this questionnaire exists till date.

Objective: To cross-culturally adapt the IPAQ-LF from English to Hindi language and to evaluate its reliability and validity.

Methods: The guidelines by IPAQ Committee were followed for cross-cultural adaptation process. The Test–retest reliability was assessed on 60 participants by administering Hindi IPAQ-LF twice within two-week time frame. The construct validity was assessed by comparing with seven-day pedometer recording.

Results: Excellent reliability was observed between total physical activity scores on repeated Hindi IPAQ-LF administrations, with interclass correlation coefficient of 0.963 at 95% confidence interval. The ICC for job, transport, Housework and Leisure domain was calculated to be 0.923, 0.839, 0.862 and 0.939, respectively, suggesting excellent reliability. The Cronbach’s alpha computed (0.82) suggests good internal consistency. The Hindi Version of IPAQ-LF also demonstrated good construct validity with Spearman correlation coefficient of 0.783. Bland–Altman analyses were performed to evaluate the level of agreement between two constructs.

Conclusion: The study demonstrates that Hindi version of IPAQ-LF is a reliable and valid tool for assessing physical activity levels for Hindi speaking population.
Backward bifurcation, basic reinfection number and robustness of an SEIRE epidemic model with reinfection
Authors: Wang Shaoli , Wang Tengfei , Qi Ya-Nen , Xu Fei
Published: December 2022

Recent evidences show that individuals who recovered from COVID-19 can be reinfected. However, this phenomenon has rarely been studied using mathematical models. In this paper, we propose an SEIRE epidemic model to describe the spread of the epidemic with reinfection. We obtain the important thresholds [Formula: see text] (the basic reproduction number) and [Formula: see text] (a threshold less than one). Our investigations show that when [Formula: see text], the system has an endemic equilibrium, which is globally asymptotically stable. When [Formula: see text], the epidemic system exhibits bistable dynamics. That is, the system has backward bifurcation and the disease cannot be eradicated. In order to eradicate the disease, we must ensure that the basic reproduction number [Formula: see text] is less than [Formula: see text]. The basic reinfection number is obtained to measure the reinfection force, which turns out to be a new tipping point for disease dynamics. We also give definition of robustness, a new concept to measure the difficulty of completely eliminating the disease for a bistable epidemic system. Numerical simulations are carried out to verify the conclusions.
Research on Used Transformer Oil (UTO) and Nanoparticles Application
Authors: Hariharan D. , Jaya N.
Published: December 2022

Transformer oil with a petroleum basis has long been used in transformers as insulation and cooling. Spent oils used as the insulating fluid in transformers are disposed after extensive use. Non-biodegradable composition of the transformer oil can pose a serious threat to the environment. A Nano Particle based Used Transformer Oil Processing Method (NP-UTOPM) is suggested in this research to reuse the used transformer oil in the battery. This work examines the effects of activated bentonite and carbon absorbents in recovering the qualities of used transformer oilby investigating the re-usage features of used transformer oil samples after reclamation treatment. 50 ml of used transformer oil is utilized for the reclaiming process, along with separate mixtures of 1%, 3%, and 5% Nano Particles (NP) and blended combinations of two absorbents. According to international regulations, oil sample characteristics such as breakdown voltage, viscosity, dielectric dissipation factor, electrical conductivity, density, specific resistance, surface tension, and temperature properties are tested before and after restoration. The sample of recycled oil is used again as a liquid insulator in batteries.
Impact of handgrip exercise and ischemic preconditioning on local and remote protection against endothelial reperfusion injury in young men
Authors: Bannell Daniel J. , Montrezol Fabio T. , Maxwell Joseph D. , Somani Yasina B. , Low David A. , Thijssen Dick H. J. , Jones Helen
Published: December 2022

Ischemic preconditioning (IPC), cyclical bouts of nonlethal ischemia, provides immediate protection against ischemic injury, which is evident both locally and remotely. Given the similarities in protective effects of exercise with ischemic preconditioning, we examined whether handgrip exercise also offers protection against endothelial ischemia-reperfusion (IR) injury and whether this protection is equally present in the local (exercised) and remote (contralateral, nonexercised) arm. Fifteen healthy males (age, 24 ± 3 yr; body mass index, 25 ± 2 kg/m2) attended the laboratory on three occasions. Bilateral brachial artery flow-mediated dilation (FMD) was examined at rest and after a temporary IR injury in the upper arm. Before the IR injury, in the dominant (local) arm, participants performed (randomized, counterbalanced): 1) 4 × 5 min unilateral handgrip exercise (50% maximal voluntary contraction), 2) 4 × 5 min unilateral IPC (220 mmHg), or 3) 4 × 5 min rest (control). Data were analyzed using repeated-measures general linear models. Allometrically scaled FMD declined after IR in the control condition (4.6 ± 1.3% to 2.2 ± 1.7%, P < 0.001), as well as following handgrip exercise (4.6 ± 1.6% to 3.4 ± 1.9%, P = 0.01), however, was significantly attenuated with IPC (4.5 ± 1.4% to 3.8 ± 3.5%, P = 0.14). There were no differences between the local and remote arm. Our findings reinforce the established protective effects of IPC in young, healthy males and also highlight a novel strategy to protect against IR injury with handgrip exercise, which warrants further study.
Sodium oxamate reduces lactate production to improve the glucose homeostasis of Micropterus salmoides fed high-carbohydrate diets
Authors: Shen Hui-Chao , Chen Zhi-Qiang , Liu Xiao-Cheng , Guan Jun-Feng , Xie Di-Zhi , Li Yuan-You , Xu Chao
Published: December 2022

The study was performed to evaluate the effects of the reduced lactate production by sodium oxamate (SO) on growth performance, lactate and glucose and lipid metabolism, and glucose tolerance of Micropterus salmoides fed high-carbohydrate (CHO) diets. In in vitro study, primary hepatocytes were incubated for 48 h in a control medium (5.5 mM glucose), a high-glucose medium (25 mM glucose, HG), or a SO-containing high-glucose medium (25 mM glucose + 50 mM SO, HG-SO). Results indicated lactate and triglyceride (TG) levels, and lactate dehydrogenase a (LDH-a) expression in the HG-SO group were remarkably lower than those of the HG group. In in vivo study, M. salmoides (5.23 ± 0.03 g) were fed four diets containing a control diet (10% CHO, C) and three SO contents [0 (HC), 100 (HC-SO1), and 200 (HC-SO2) mg·kg−1, respectively] of high-CHO diets (20% CHO) for 11 wk. High-CHO diets significantly reduced weight gain rate (WGR), specific growth rate (SGR), p-AMPK-to-t-AMPK ratio, and expression of insulin receptor substrate 1 (IRS1), insulin-like growth factor I (IGF-I), insulin-like growth factor I receptor (IGF-IR), fructose-1,6-biphosphatase (FBPase), peroxisome proliferator-activated receptor α (PPARα), and carnitine palmitoyl transferase 1α (CPT1α) compared with the C group, whereas the opposite was true for plasma levels of glucose, TG, lactate, tissue glycogen, and lipid contents, and expression of LDH-a, monocarboxylate transporter 1 and 4 (MCT1 and MCT4), insulin, glucokinase (GK), pyruvate dehydrogenase E1 subunit (PDH), sterol-regulatory element-binding protein 1 (SREBP1), fatty acid synthase (FAS). The HC-SO2 diets remarkably increased WGR, SGR, p-AMPK-to-t-AMPK ratio, and expression of IRS1, IGF-I, IGF-IR, GK, PDHα, PDHβ, FAS, acetyl-CoA carboxylase 1 (ACC1), PPARα, and CPT1α compared with the HC group. Besides, HC-SO2 diets also enhanced glucose tolerance of fish after a glucose loading. Overall, the reduced lactate production by SO benefits growth performance and glucose homeostasis of high-CHO-fed M. salmoides through the enhancement of glycolysis, lipogenesis, and fatty acid β-oxidation coupled with the suppression of glycogenesis and gluconeogenesis.
Hsa_circ_0006988 Promotes Sorafenib Resistance of Hepatocellular Carcinoma by Modulating IGF1 Using miR-15a-5p
Authors: Qiu Rui , Zeng Zhifeng
Published: December 2022

Background. Hepatocellular carcinoma (HCC) is the most frequently occurring cancer and contributes to the largest number of cancer-associated deaths worldwide. Recent evidence suggests that circular RNAs (circRNAs), which are critical for HCC etiology and metastasis, are distinctly modulated in HCC. Nevertheless, the underlying mechanism of circRNA-mediated sorafenib resistance (SOR) in HCC is yet to be determined. Methods. The hsa_circ_0006988, IGF1, and miR-15a-5p contents were quantified via ELISA and quantitative real-time polymerase chain reaction (qRT-PCR), respectively. Cell Counting Kit-8 (CCK-8) was used for the IC50 evaluation. Lastly, associations among hsa_circ_0006988, IGF1, and miR-15a-5p were validated through dual-luciferase reporter (DLR) and RNA immunoprecipitation (RIP) assays. Results. Herein, a new circRNA, hsa_circ_0006988, was identified, and its levels were markedly enhanced in SOR-resistant (SOR-R) HCC tissues. Functionally, hsa_circ_0006988 strongly suppressed SOR toxicity in vitro. Our examination of the signaling pathway revealed that hsa_circ_0006988 sequestered miR-15a-5p, a negative modulator of IGF1, thus suggesting that hsa_circ_0006988 deficiency diminished SOR resistance of HCC, and this action utilized the release of excess miR-15a-5p, which suppressed IGF1 levels. Moreover, miR-15a-5p overexpression reversed the hsa_circ_0006988-mediated SOR-R and enhanced IGF1 levels in HCC cells. Conclusion. Hsa_circ_0006988 partly promoted the SOR-R of HCC cells through miR-15a-5p sequestering and upregulation of IGF1 levels.
Extended Statement of the Optimal Control Problem and Machine Learning Approach to Its Solution
Authors: Shmalko Elizaveta , Diveev Askhat
Published: December 2022

Engineers strive to realize the goal of control in the best possible way based on a given quality criterion when developing control system. The well-known optimal control problem requires finding a solution as a function of time. Such a function cannot be directly used to control a real object because its application corresponds to an open-loop control system and engineers usually complete it with a feedback stabilization system. Hence, there is an obvious need to reformulate the optimal control problem so that its solution can be directly applied to real objects. The paper presents a new extended statement of the optimal control problem. An additional requirement for the control function is introduced to give the system describing the control object properties that will ensure the stability of solutions. The desired control function must provide for the optimal trajectory given the properties of the attractor in the neighbourhood. The solution to the extended optimal control problem can be directly used to control a real object. The paper presents a computational machine learning approach to solving the extended problem of optimal control based on the application of a synthesized optimal control technique. Examples of the practical solution to the stated problem are given to illustrate the efficiency of the approach, where the solution to the conventional optimal control problem is compared with the proposed extended one in the presence of perturbations in models and initial conditions.
Path to Increasing p-B11 Reactivity via ps and ns Lasers
Authors: Mehlhorn Thomas A. , Labun Lance , Hegelich Bjorn Manuel , Margarone Daniele , Gu Ming Feng , Batani Dimitri , Campbell E. Michael , Hu S. X. , Ramakrishna Bhuvanesh
Published: December 2022

The Lawson criterion for proton-boron (p-11B)
thermonuclear fusion is substantially higher than that for deuterium-tritium
(DT) because the fusion cross section is lower and peaks at higher ion
energies. The Maxwellian averaged p-11B reactivity
peaks at several hundred keV, where bremsstrahlung radiation emission may
dominate over fusion reactions if electrons and ions are in thermal
equilibrium and the losses are unrestricted. Nonequilibrium burn has often
been suggested to realize the benefits of this aneutronic reaction, but the
predominance of elastic scattering over fusion reactivity makes this
difficult to achieve. The development of ultrashort pulse lasers (USPL) has
opened new possibilities for initiating nonequilibrium thermonuclear burns
and significant numbers of p-11B alpha particles have
been reported from several experiments. We present an analysis that shows
that these significant alpha yields are the result of beam fusion reactions
that do not scale to net energy gain. We further find that the yields can be
explained by experimental parameters and recently updated cross sections
such that a postulated avalanche mechanism is not required. We use this
analysis to understand the underlying physics of USPL-driven nonequilibrium
fusion reactions and whether they can be used to initiate fusion burns. We
conclude by outlining a path to increasing the p-11B
reactivity towards the goal of achieving ignition and describing the design
principles that we will use to develop a computational point
design.
Prevalence and Associated Risk Factors of Soil-Transmitted Helminth Infections among Schoolchildren around Lake Tana, Northwest Ethiopia
Authors: Getaneh Melsew , Hailegebriel Tamirat , Munshea Abaineh , Nibret Endalkachew
Published: December 2022

Background. Soil-transmitted helminths (STHs) are among the most common neglected tropical diseases widely distributed in tropical countries with poor socioeconomic development. Ascaris lumbricoides, Trichuris trichiura, and hookworm are the three major STHs. This study aimed to determine the prevalence of STHs and associated risk factors among schoolchildren in selected primary schools around Lake Tana, Northwestern Ethiopia. Methods. A school-based cross-sectional study was conducted from February to May 2021 involving 337 study participants. A systematic random sampling method was utilized to select the study participants from the selected schools. Data related to sociodemographic characteristics of the study participants and risk factors for STH infections were collected using a pretested questionnaire. Stool samples were collected in sterile plastic containers from each participant and processed using Kato–Katz thick fecal smear and Ritchie’s concentration techniques. The data were analyzed using the Statistical Package for Social Sciences software tool version 23, and factors with a

p
<
0.05

were considered as statistically significant. Results. The overall prevalence of STH infection was 38.3% (95% CI: 33.1–43.7). Hookworm infection was the predominant STH infection, which was detected in 26.1% schoolchildren followed by A. lumbricoides (14.8%) and T. trichiura (1.5%). Most of the study subjects (34.1%) had single infections, whereas only 4.2% study subjects had multiple helminthic infections. Among the risk factors considered in the study, lack of shoe wearing habit (adjusted odds ratio [AOR]=29.5; 95% confidence interval [CI]=6.59–132.55;

p
<
0.001

), lack of knowledge on the prevention and control methods (

AOR
=
5.41

; 95% CI = 2.44–11.98;

p
<
0.001

), engagement in irrigation activities (

AOR
=
2.14

; 95% CI = 1.02–4.57,

 
p
=
0.049

), lack of toilet (

AOR
=
3.06

; 95% CI = 1.31–7.16;

 
p
=
0.01

), children grades of 5–8 (

AOR
=
2.62

; 95% CI = 1.26–5.43;

p
=
0.01

), playing on soils (

AOR
=
5.90

; 95% CI = 2.79–12.49;

p
<
0.001

), lack of fingernail trimming habit (

AOR
=
3.21

; 95% CI = 1.57–6.55;

p
=
0.001

), and male gender (

AOR
=
2.28

; 95% CI: 1.19–4.39;

 
p
=
0.013

) were significant explanatory factors for STH infection among schoolchildren in the study area. Conclusions. The present study showed that STHs were common among schoolchildren around Lake Tana. Therefore, education on personal and environmental hygiene should be taken into account to reduce the prevalence of STH infection in the study area.
Evaluation of Breakthrough Technological Innovation Capability of Petroleum Equipment Manufacturing Enterprises Based on the CFPR‐TIFNs Model
Authors: Luo Hongyun , Lin Xiangyi
Published: December 2022

“Internet + innovation” is a new emerging paradigm for breakthrough technological innovation, which is more complex than traditional scenarios because “Internet +” has completely overturned the acquisition of creativity and knowledge. This article aims to evaluate the breakthrough technological innovation capability (BTIC) of petroleum equipment manufacturing enterprises under the new paradigm of “Internet + innovation.” This article constructs an index system that can reflect the characteristics of “breakthrough” and “Internet +” in five dimensions. Due to the difficulties of conducting quantitative measurements for the novel index system, a hybrid evaluation model based on a consistent fuzzy preference relationship (CFPR) and triangular intuitionistic fuzzy numbers (TIFNs) is put forward for the evaluation of BTIC. The main contribution of this article is to propose an index system and model for the evaluation of BTIC under the “Internet + innovation” paradigm, which is conducive to improving the quality of breakthrough technological innovation activities under more complex scenarios. The CFPR‐TIFNs model can not only effectively calculate the BTIC of petroleum equipment manufacturing enterprises but also deeply analyze the influencing factors for their relatively weak technological innovation capability. This article provides a new methodology to solve problems in a more complex technological innovation system.
Extraction, Profiling, and Characterization of Phytosterols and Triterpenoids from Pili (Canarium ovatum Engl.) Pulp Oil Exhibiting Antioxidant and Antibacterial Properties
Authors: Dumandan Nico G. , Kagaoan Annie Cita T. , Acda Ranelle D. P. , Tumambing Caren R. , Pham Laura J.
Published: December 2022

Pili (Canarium ovatum Engl.), an indigenous tree found in the Philippines, is highly regarded for its fruit due to its high economic value. During processing, the pulp is often discarded as waste but contains considerable amounts of oil and bioactive minor lipid components. The present study explored the antioxidant and antibacterial properties of saponified diethyl ether extract of pili pulp oil and related this activity to the nature of compounds present in the extract through GCMS. The extract indicated the elution of 18 major compounds which are mostly cyclic triterpenic (α-and β-amyrin, lupenone, and β-amyrone) and phytosterol (β-sitosterol, brassicasterol, and stigmasterol) class of compounds. Characterization of the bioactivity of the extract showed high antioxidant activities measured by DPPH radical scavenging (EC50: 74.45 ± 1.29 μg/mL) and lipid peroxidation inhibition (EC50: 3.02 ± 0.06 μg/mL) activities that were comparable with that of α-tocopherol. Moreover, an observed bactericidal activity was demonstrated by the extract against E. coli and S. typhi with MIC values of 40 and 35 μg/mL, respectively. The observed bioactivity of the pili pulp oil extract can be attributed to these compounds which may provide desirable health benefits.
Design and Investigation of an Asymmetric Logarithmic Spiral Gear Drive
Authors: He Zenghuang , Gong Xu , Fu Shengping , Luo Shanming , Mo Jingyu
Published: December 2022

Sliding on gear teeth working surfaces has negative effects on the performances of gears, such as tooth surface wear, pitting, etc. In order to reduce the gear sliding during high speed and heavy load, a new type of pure rolling gear, named as an asymmetric logarithmic spiral gear, is designed referring to the characteristics of the Issus planthopper gear. To explore the meshing principle of this kind of gear, the equations of the teeth surfaces, their working lines, and contact lines are all derived. Then, the tooth profile parameters and slip rate are calculated. To ensure accurate gear engagement, the gear interferences are analyzed to build the gear models. Subsequently, the gear is performed to simulate its working condition by the finite element method. Furthermore, the results are compared with that of the pure rolling single arc gear. As a result, the asymmetric logarithmic spiral gear behaviors less contact and bending stresses than the pure rolling single arc gear under the same work condition.
Correlation Analysis of Gene and Radiomic Features in Colorectal Cancer Liver Metastases
Authors: Wang Xuehu , Li Nie , Guo Haifeng , Yin Xiaoping , Zheng Yongchang
Published: December 2022

Colorectal cancer liver metastasis (CRLM) was one of the cancers with high mortality. Clinically, the target point was determined by invasive detection, which increased the suffering of patients and the cost of treatment. If the target point was found through the relationship between early radiomic information and genetic information, it was expected to assist doctors in diagnosing disease, formulating treatment plans, and reducing the pain and burden of patients. In this study, gene coexpression analysis and hub gene mining were first performed on the gene data; secondly, quantitative radiomic features were extracted from CT-enhanced radiomic data to obtain features highly correlated with CRLM; and finally, we analyzed the relationship between gene features and radiomic feature correlations by establishing a link between early radiomic features and gene sequencing and finding highly correlated expressions. This experiment demonstrated that radiomic features could be used to mine gene attributes. Based on the four previously identified genes (NRAS, KRAS, BRAF, and PIK3CA), we identified two novel genes, MAPK1 and STAT1, highly associated with CRLM. There were specific correlations between these 6 genes and radiomic features (shape_elongation, glcm, glszm, firstorder_10percentile, gradient, exponent_firstorder_Range, and gradient_glszm_SmallAreaLowGrayLevel). Therefore, this paper established the correlation between radiomic features and genes, and through radiomic features, we could find the genes associated with them, which was expected to achieve noninvasive prediction of liver metastasis.
Bioinformatic Analysis of Genetic Factors from Human Blood Samples and Postmortem Brains in Parkinson’s Disease
Authors: Yao Longping , Lin Kai , Zheng Zijian , Koc Sumeyye , Zhang Shizhong , Lu Guohui , Skutella Thomas
Published: December 2022

Parkinson’s disease (PD) is one of the most prevalent neurodegenerative disorders characterized by motor and nonmotor symptoms due to the selective loss of midbrain dopaminergic neurons. Pharmacological and surgical interventions have not been possible to cure PD; however, the cause of neurodegeneration remains unclear. Here, we performed and tested a multitiered bioinformatic analysis using the GEO and Proteinexchange database to investigate the gene expression involved in the pathogenesis of PD. Then we further validated individual differences in gene expression in whole blood samples that we collected in the clinic. We also made an interaction analysis and prediction for these genetic factors. There were in all 1045 genes expressing differently in PD compared with the healthy control group. Protein-protein interaction (PPI) networks showed 10 top hub genes: ACO2, MDH2, SDHA, ATP5A1, UQCRC2, PDHB, SUCLG1, NDUFS3, UQCRC1, and ATP5C1. We validated the ten hub gene expression in clinical PD patients and showed the expression of MDH2 was significantly different compared with healthy control. Besides, we also identified the expression of G6PD, GRID2, RIPK2, CUL4B, BCL6, MRPS31, GPI, and MAP 2 K1 were all significantly increased, and levels of MAPK, ELAVL1, RAB14, KLF9, ARF1, ARFGAP1, ATG7, ABCA7, SFT2D2, E2F2, MAPK7, and UHRF1 were all significantly decreased in PD. Among them, to our knowledge, we presently have the most recent and conclusive evidence that GRID2, RIPK2, CUL4B, E2F2, and ABCA7 are possible PD indicators. We confirmed several genetic factors which may be involved in the pathogenesis of PD. They could be promising markers for discriminating the PD and potential factors that may affect PD development.
LINC01857 Exacerbates the Malignant Behaviors of Endometrial Carcinoma Cells by Sponging miR-19b-3p and Recruiting ELAVL1 to Upregulate MYCN
Authors: Cao Rong , Zhao Jiao , Zhang Jingru
Published: December 2022

Objectives: Long intergenic nonprotein coding RNA 1857 (LINC01857) has been identified to play an oncogenic role in different cancers. Nevertheless, its expression and biological role in endometrial carcinoma (EC) are not clear. Design: This study was a basic research on cell biology. Materials, Setting, Methods: EC cell lines were used in this study. RNA expressions in EC cells were examined through RT-qPCR. The impacts of LINC01857 silence on EC cell proliferation, apoptosis, migration, and invasion were evaluated through functional assays, and the underlying regulatory mechanism at a molecular level was analyzed via mechanism assays. Results: LINC01857 expression was aberrantly high in EC cells. LINC01857 silence inhibited EC cell proliferation, migration, and invasion and promoted EC cell apoptosis. Mechanically, LINC01857 acted as a sponge of miR-19b-3p. Upregulation of miR-19b-3p hampered EC cell malignant behaviors. MYCN proto-oncogene, bHLH transcription factor (MYCN) was the target gene of miR-19b-3p, and MYCN depletion repressed the malignant behaviors of EC cells. Further, LINC01857 was verified to recruit ELAV-like RNA-binding protein 1 (ELAVL1) to stabilize MYCN mRNA. Limitations: The function of LINC01857 in EC remains to be further investigated with clinical samples and more cell lines involved. Conclusions: LINC01857 exacerbated EC cell malignant behaviors via the miR-19b-3p/ELAVL1/MYCN axis.
Evaluation of the Implementation and Diagnostic Accuracy of the Paris Classification for Reporting Urinary Cytology in Voided Urine Specimens: A Cyto-Histological Correlation Study in a Cancer Center
Authors: Lobo João , Lobo Cláudia , Leça Luís , Rodrigues Ângelo , Henrique Rui , Monteiro Paula
Published: December 2022

Introduction: The Paris classification highlights the need to focus on accurately identifying high-grade urothelial carcinoma (HGUC). Herein, we aimed to assess the overall implementation and diagnostic performance of the Paris classification for reporting urinary cytology in a cancer center. Methods: All urinary cytology reports from July 2018 to December 2019 were collected (n = 1,240). Only voided urine samples were included (n = 1,180). Risk of high-grade malignancy (ROHM) was calculated for each Paris category. The diagnostic performance of urinary cytology was assessed, including sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy. Results: The distribution of categories was: 0.3% unsatisfactory, 90.5% negative for HGUC, 5.6% atypical urothelial cells (AUC), 1.6% suspicious for HGUC, 1.9% HGUC, and 0.1% other malignancies. No diagnosis of low-grade urothelial neoplasia was given. The ROHM was 21.4% for negative for HGUC, 66.7% for AUC, 91.7% for suspicious for HGUC, and 100% for HGUC. When using suspicious for HGUC as a cutoff, the diagnostic performance of urinary cytology in identifying HGUC histology was 46% sensitivity, 98% specificity, 96% PPV, 68% NPV, and 74% accuracy. Conclusion: Specificity of urinary cytology was very high (with only 1 false-positive result), which is important since this will trigger a clinical intervention. The ROHM for each category was in accordance with literature, except for AUC where ROHM was slightly higher (66.7%). This may be explained by the study population characteristics (cancer center; many patients treated with intravesical therapies; lack of clinical annotation for patients referred from outside institutions).
Serum CCL22 Increased in Advanced Melanoma Patients with Liver Metastases: Report of 5 Cases
Authors: Ohuchi Kentaro , Amagai Ryo , Kambayashi Yumi , Asano Yoshihide , Fujimura Taku
Published: December 2022

Advanced melanoma patients with liver metastases show a limited response to immunotherapy by the induction of regulatory T cells and depletion of effector cells, which leads to a poor prognosis. Tumor-associated macrophages (TAMs) induce apoptosis of activated antigen-specific CD8+ T cells in melanomas, leading to induction of tolerance to immune checkpoint inhibitors. In addition, TAMs produce various chemokines, and several serum pro-inflammatory chemokines measured at baseline are useful for the prediction of the efficacy of immunomodulatory drugs. In this study, serum levels of CCL22, CXCL5, and CXCL10 were evaluated by ELISA at baseline in 10 melanoma patients, 5 with liver metastases and 5 with lung metastases, treated with anti-PD1 Abs. Serum levels of CCL22, but not CXCL5 and CXCL10, were increased in patients with liver metastases compared to those with lung metastases or historical controls. The present data suggest that elevated serum CCL22 levels might be a biomarker for liver metastases in melanoma patients.