bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparative Transcriptome Analysis of Leaf, Stem, and Root Tissues of Semiliquidambar Cathayensis Hung T. Chang Reveals Candidate Genes Involved in Terpenoid Biosynthesis
Authors: tian xiaoming , Yan Lihong , Jiang Liyuan , Xiang Guangfeng , Li Gaofei , Wu Jia
Published: January 2022

Background

The roots, branches, leaves, bark, and nectar of Semiliquidambar cathayensis Hung T. Chang can treat rheumatoid arthritis, lumbar muscle strain, and other diseases. However, limited knowledge of the S. cathayensis Chang genome hampers further research on elucidating the pathways underlying active ingredient synthesis and regulation of its accumulation. In this study, we aimed to generate data to elucidate biosynthetic pathway of the active ingredient synthesis and related molecular mechanisms.
Methods

We conducted transcriptome sequencing of S. cathayensis Chang leaves, stem epidermis, stem xylem, root epidermis, and root xylem.
Results

We identified 88,582 unigenes, among which, 36,144 unigenes were annotated to the nr protein database, 21,981 to the Gene Ontology database, 11,565 to the Clusters of Orthologous Groups database, 24,209 to the Pfam database, 21,685 to the SWISS-PROT database, and 12,753 to the Kyoto Encyclopedia of Genes and Genomes (KEGG), with 5,072 unigenes common to all six databases. Of those annotated using the KEGG database, 187 unigenes were related to the terpenoid metabolism pathway, and expression analysis of the related genes indicated that the mevalonate and methylerythritol 4-phosphate pathways play different roles in terpenoid biosynthesis in different tissues of S. cathayensis Chang.
Conclusions

These findings greatly expand the gene resources of S. cathayensis Chang and provide basic data for the study of the biosynthetic pathways and molecular mechanisms of terpenoids.
Growing Season Harvests of Shrub Willow Have Higher Nutrient Removals and Lower Yields Compared to Dormant Season Harvests
Authors: de Souza Daniel PL , Eisenbies Mark , Volk Timothy
Published: January 2022

The commercial establishment of shrub willow biomass crops with three- or four-year harvest cycles raises concerns about nutrient removals. Furthermore, commercial harvesters in the northeast United States have begun to open the harvest season in late summer to early fall in order to ensure access on poorly drained, marginal sites because the ground no longer reliably freezes in winter. The potential impact that increased leaf-on harvesting has on nutrient export and its implications for crop management are not well known. This study examined the effects of six harvest dates over 10 months on the nutrient removal and second rotation biomass production of four shrub willow cultivars on a site in central New York State. First rotation harvests yielded between 77 and 85 Mg ha-1 during the growing season, and was between 93 and 104 Mg ha-1 after dormancy. There was a significant effect of harvest timing on the removal of N, K, Ca, Mg, and S. Willow harvested in October removed comparatively higher amounts of N (77.1 kg ha-1 y-1), P (11.2 kg ha-1 y-1), Ca (163.7 kg ha-1 y-1), Mg (9.9 kg ha-1 y-1), and S (8.9 kg ha-1 y-1) than in other harvests. Potassium removal was greater for plants harvested in June and August (51.2 and 52.5 kg ha-1 y-1 respectively). Significant interactions between harvest timing and cultivars suggest that targeted cultivar selection and deployment could maintain yields and limit excess nutrient losses.
Cytotoxic Effect of Samarium(III)-Based Complexes: Synthesis, Characterization and Photoluminescence Properties
Authors: SARIOGLU AHMET ORAL , kahraman demet taşdemir , köse Aysegül , sönmez mehmet
Published: January 2022

Three new homoleptic six-coordinate Sm(III) complexes have been synthesized from diketone ligand with different substituent groups. The structural properties of these compounds have been investigated using elemental analysis, UV-Vis, and FT-IR approaches. Then, their photoluminescence properties of the synthesized Sm complexes have been examined.Also, the cytotoxic activities of the complexes have been studied against to human epidermoid carcinoma cell (HTB-54) and normal bronchus epithelial cell (BEAS-2B). According to result, the [Sm(MPBP-1,3PPon)3]·H2O) (IC50: 11.05 μM) complex was more active than [Sm(BMP-1,3PPon)3]·2H2O (IC50:58.64 μM) and [Sm(BCP-1,3PPon)3]·H2O (IC50: >500 μM) complexes. Otherwise it was no effect on normal cell (BEAS-2B). This result shows that complex [Sm(MPBP-1,3PPon)3]·H2O) has the potential to be the ideal chemotherapeutic drug.
Economic Burden of Rheumatoid Arthritis in Iran: A Societal Perspective Economic Burden of R.A.
Authors: Rezaee Mehdi , Lotfi Farhad , Gholami Ahmad , Azizpoor Jassem , Aflaki Elham , Vazin Afsaneh , Keshavarz Khosro
Published: January 2022

Background: Rheumatoid arthritis (RA) is a progressive, chronic systemic inflammatory disease and impose a significant economic burden on patients and societies if not controlled. This study aimed to determine the economic burden of RA in southern Iran in 2019. Methods: This economic burden study was carried out as cross-sectional research in 2019 in southern Iran, in which 765 patients were included. The prevalence-based and bottom-up approaches were also used to prepare the cost information and calculate the costs, respectively. The human capital approach was used to calculate the indirect costs as well. Results: The results showed that the economic burden of RA in Iran was $ 3,744,967,993 PPP in 2019. In addition, the mean annual costs of RA per patient in remission, low, and moderate-to severe states and the total cost were $ 11,925.98, $ 11,887.49, $ 12,803.45, and $ 12,155.08 PPP, respectively in 2019.Conclusions: RA imposed a significant economic burden on the community and patients, and DMC, especially the cost of drugs, were the most important component. It is suggested to provide necessary facilities to produce RA drugs in the country and expand home care services in order to reduce the economic burden.
Metachronous Polycythemia Vera and Multiple Myeloma in an Ethiopian patient
Authors: Anbessie Zablon Mesfin , GebreEgziabher Amha Gebremedhin
Published: January 2022

Introduction- Dual hematologic malignancies whether synchronous or metachronous are a rare finding in the hematologic literature. A retrospective review has estimated 1.5% of patients with a single hematologic malignancy will go on to develop a second hematologic malignancy. The occurrence of polycythemia vera with multiple myeloma is an even rarer finding with only 18 cases being described over the past 75 years.Case- A 52 years old male patient who was a known Jak-2 positive polycythemia vera patient on hydroxyurea and with reasonable hematologic profiles, insidiously developed severe anemia requiring transfusion, despite discontinuation of hydroxyurea. Along with the anemia the patient progressively developed fatigue, leg swelling, back pain, decreased urine output, and his creatinine increased from a baseline of 1.4mg/dl to 9mg/dl. His examination was significant for massive hepatosplenomegaly. His labs showed lytic skull bone lesions, an IgG Lambda monoclonal spike, serum calcium of 13.3mg/dl, and a 24-hour urine protein of 7g.Discussion and conclusion-We were able to demonstrate that our patient had a similar sociodemographic resemblance with prior reported cases but differed in that he had more aggressive myeloma. We advocate clinicians to have a high index of suspicion as well as an open mind for the consideration of dual hematologic malignancies during their practice.
A long-term anti-inflammation markedly alleviated high-fat diet induced obesity by repeated administrations of overexpressing IL-10 human umbilical cord-derived mesenchymal stromal cells
Authors: Wang Liudi , Gao Tianyun , Li Yu , Xie Yuanyuan , Zeng Sheng , Tai Chenxu , Feng Yirui , Shen Pingping , Wang Bin
Published: January 2022

Objectives

Obesity is a chronic process and could activate various inflammatory responses, which in turn aggravates obesity and related metabolic syndrome. Here we explored whether long-term inhibition of inflammation could successfully alleviate high-fat diet (HFD) induced obesity.
Methods

We constructed stable overexpressing interleukin 10 (IL10) human umbilical cord-derived mesenchymal stromal cells (HUCMSCs) which repeatedly were applied to obesity mice with HFD feeding to obtain a long-term anti-inflammation based on the prominent anti-inflammation effects of IL10 and immunomodulatery effects of HUCMSCs. Then we monitored the features of obesity including body weight, serum ALT, AST, and lipids. In addition, glucose homeostasis was determined by glucose tolerance and insulin sensitivity tests. The infiltrated macrophages in adipose tissues and hepatic lipid accumulation were detected and the expressions of adipogenesis and inflammatory genes in adipose tissues were examined by real time (RT)-PCR and western blot analysis.
Results

Compared with HUCMSCs, IL10-HUCMSCs treatment had much better anti-obesity effects including body weight reduction, less hepatic lipids accumulation, lower amount and size of adipocyte, greater glucose tolerance, less systemic insulin resistance, and less adipose tissue inflammation in HFD feeding mice. Finally, IL10-HUCMSCs could decrease the activation of MAPK JNK of adipose tissue induced by HFD. The inhibition of MAPK JNK signal pathway by a small chemical molecule SP600125 in 3T3-L1 cells, a preadipocyte line, reduced the differentiation of adipocytes and lipid droplet accumulation.
Conclusion

a lasting anti-inflammation based on gene modified stem cell therapy is an effective strategy in preventing diet-induced obesity and obesity-related metabolic syndrome.
Investigating the influence of the new ride-hailing policy on air quality using regression discontinuity design
Authors: Li Mengna , Pan Xiongfeng
Published: January 2022

With the increase of the number of ride-hailing, the traffic congestion and environmentalpollution has exacerbated. A new ride-hailing policy was formed as a means of administrative control to improve the negative externality. However, the improvement of air quality caused by the new ride-hailing policy has not been effectively verified. This study employed regression discontinuity design (RDD) to explore the causal relationship between the air quality in Beijing and the new ride-hailing policy to reduce the endogeneity problems. The main results show that the implementation of the new policy reduces air quality index (AQI), particulate matter 10(PM10), and ozone(O3) by 14%, 12%, and 16%, respectively in the OLS regression analysis. After applying the RDD, this study found that the implementation of the new policy reduced AQI, PM10, and O3 by 43%, 30%, and 42%. The regression value of regression discontinuity was higher than that of OLS. Additionally, the robustness test reveals that RDD is reasonable. The findings suggest that the implementation of the new ride-hailing policy exerts an improvement effect on air quality. Policy implications to further promote the new ride-hailing policy are hence discussed.
Modified Analytical Result of Catharanthus Roseus by Using PIXE Through Complementary Techniques
Authors: Satyanarayana Avupati Venkata Surya , Guru Tharividi Venkata Siva Parvathi Veera Satya
Published: January 2022

Catharanthus roseus is a medicinal and herbal plant that has been studied extensively for its biological effects on the metabolic and immunological systems, as well as human health. Using various analytical techniques, the concentrations of the elements in Catharanthus roseus vary. Proton-induced x-ray emission with a 2-3 MeV energy apparatus with a Si (Li) detector was used to identify the important major, minor, and traces for the study, which had good sensitivity, selectivity, and reduced detection limits with correct results. The C. Roses plant includes an abundance of vital components and minerals, according to the results of the analysis. Cl, K, Ca, Ti, V, Mn, Fe, Cu, Zn, Br, and Sr were all investigated in substantial amounts. However, when compared to other complementary analytical techniques, elements with low Z, such as Na, Mg, Al, P, and S, and with a medium Z, such as Sc, Se, Cr, and Co, as well as high Z, such as Cd, Rb, Ba, Pb, and U were not identified through improper and overlaps analysis of the PIXE spectrum. As a result, the reasons for the analysis of the non-detected elements should be evaluated, and the results should be finalized using other C. roseus complementary analytical procedures.
Respiratory Viral Infections in Cancer Patients: Epidemiological, Clinical and Cost-Effective Study from a Developing Country
Authors: Bansal Nitin , Sachdeva Neelam , Bhurani Dinesh , Kapoor Gauri , Yadav Pinky , Goyal Sumit , Talwar Vineet , Batra Ullas
Published: January 2022

Background: Diagnosis of respiratory viral pathogens can lead to therapeutic changes, improvement in infection control practices and reduction in use of antibiotics. Methods: This is a retrospective study which looked into the case records of patients (June 2020-Dec 2021) who were diagnosed with a respiratory viral infection. Demographic, clinical and antibiotic prescription patterns of these patients were studied. Inter-group analysis was done between antibiotic de-escalation cohort and non-descalation cohort. Results: Total of 57 patients were identified with median age of 40 years (range: 3-68), out of which 38 (66.6%) were males. Hematological malignancies were present in 45 (78.9%) of patients, whereas 14 (24.5%) patients were stem cell transplant recipients. Severe neutropenia was seen in 32 (56.1%) patients with median duration of neutropenia of 7 (range 5-20) days. RSV (36.8%) was the most common virus detected followed by rhinovirus (19.3%) and influenza (19.3%). Antibiotic de-escalation was done in 33 (57.8%) of patients and in 13 (22.8%) bacterial co-infection was diagnosed. More than 3/4th patients were shifted to isolation and nearly 9000 INR per patient were saved by de-escalation of antibiotics. Death occurred in 4 (7.0%) patients. On inter-group analysis, non-de-escalation cohort had longer length of stay (10 vs 3 days; p =0.005), no antibiotic cost reduction (0 vs 9620; p=0.0003), higher mortality (16.6% vs 0%; p =0.01) & higher rhinovirus detection rates (41.6% vs 3%; p=0.0002).Conclusion: Diagnosis of respiratory viral infection helped in improving antibiotic stewardship and infection control practices.
Discovery of Polar Semiconducting Scandium Nitride as an Infrared Plasmon and Phonon-Polaritonic Material
Authors: Maurya Krishna , Rao Dheemahi , Acharya Shashidhara , Rao Pavithra Rao , Pillai Ashalatha , Selvaraja Shankar , Garbrecht Magnus , Saha Bivas
Published: January 2022

Interaction of light with collective charge oscillations termed as plasmon-polariton and with polar lattice vibrations termed phonon-polariton is a new frontier in nano-photonics. Traditionally doped-semiconductors and conducting metal oxides (CMO) are used to achieve plasmon-polaritons in the near-to-mid infrared (IR), while polar dielectrics are utilized for realizing phonon-polaritons in the long-wavelength IR (LWIR) spectral regions. However, demonstrating plasmon- and phonon-polariton in one host material with low-loss is challenging due to the mutually conflicting physical property requirements. In this article, we demonstrate high-quality tunable short-wavelength IR (SWIR) plasmon-polariton and LWIR phonon-polariton in complementary metal-oxide-semiconductor (CMOS) compatible group III-V polar semiconducting scandium nitride (ScN) thin films. We achieve both resonances by utilizing n-type (oxygen) and p-type (magnesium) doping in ScN that allows modulation of carrier concentration from 5 × 1018 to 1.6 × 1021 cm-3. Our work enables infrared nano-photonics with an epitaxial group-III semiconducting nitride, opening the possibility for practical applications.
Checkerboard solid of dipolar excitons in a two-dimensional lattice
Authors: Dubin Francois , Lagoin Camille , Bhattacharya Utso , Grass Tobias , Chhajlany Ravi , Salomon Tymek , Baldwin Kirk , Pfeiffer Loren , Lewenstein Maciej , Holzmann Markus
Published: January 2022

The Hubbard model constitutes one of the most celebrated theoretical frameworks of condensed-matter physics. It describes strongly correlated phases of interacting quantum particles confined in a lattice potential. For bosons, in the last two decades the Hubbard Hamiltonian has been deeply scrutinised in the regime of short-range on-site interactions. On the other hand, extensions to longer-range off-site couplings between neighbouring lattice sites have remained mostly elusive experimentally. Entering this regime constitutes a well identified research frontier where quantum matter phases can spontaneously break the lattice symmetry. Here we unveil one of such phases, precisely the long-sought-after checkerboard solid. It is accessed by confining semiconductors dipolar excitons in a two-dimensional square lattice. The exciton checkerboard is signalled by a strongly minimised compressibility at half-filling of the lattice sites, in quantitative agreement with theoretical expectations. Our observations thus highlight that dipolar excitons enable controlled implementations of extended Bose-Hubbard Hamiltonians.
Diagnostic Pharmacokinetics: how brain-derived biomarkers distribute through the human body, and how this affects their diagnostic significance - the case of S100B
Authors: Murcko Robert , Marchi Nicola , Bailey Damian , Janigro Damir
Published: January 2022

Blood biomarkers of neurological diseases are often employed to rule out or confirm the presence of significant intracranial or cerebrovascular pathology or for the differential diagnosis of conditions with similar presentations (e.g., hemorrhagic vs. embolic stroke). More widespread utilization of biomarkers related to brain health is hampered by our incomplete understanding of the kinetic properties, release patterns, and excretion of molecules derived from the brain. This is, in particular, true for S100B, an astrocyte-derived protein released across the blood-brain barrier (BBB). We developed an open-source pharmacokinetic computer model that allows investigations of a biomarker’s movement across the body, the sources of a biomarker’s release, and its elimination. This model was derived from a general in silico model of drug pharmacokinetics adapted for protein biomarkers. We improved the model's predictive value by adding realistic blood flow values, organ levels of S100B, lymphatic and glymphatic circulation, and glomerular filtration for excretion in urine. Three key variables control biomarker levels in blood or saliva: blood-brain barrier permeability, the S100B partition into peripheral organs, and the cellular levels of S100B in astrocytes. A small contribution to steady-state levels of glymphatic drainage was also observed; this mechanism contributed to the uptake of organs of circulating S100B. Additionally, this open-source model can also mimic the kinetic behavior of other markers, such as GFAP or NF-L. Our results show that S100B, after uptake by various organs from the systemic circulation, can be released back into systemic fluids at levels that do not significantly affect the clinical significance of venous blood or salivary levels after an episode of BBB disruption.
Impact of Risk Perception on Trust in Government and Self-Efficiency During COVID-19 pandemic: Does Social Media Content Help Users Adopt Preventative Measures?
Authors: Hassan Mohammed Salah , Halbusi Hussam Al , Najem Ali , Razali Asbah , Williams Kent A.
Published: January 2022

The public’s actions will likely have a significant effect on the course of the novel coronavirus (COVID-19) pandemic. Human behavior is conditioned and shaped by information and people’s perceptions. This study investigated the impact of risk perception on trust in government and self-efficacy. It examined whether the use of social media helped people adopt preventive actions during the pandemic. To test this hypothesis, the researchers gathered data from 512 individuals (students and academics) based in Malaysia during the COVID-19 pandemic. Our results suggested that risk perception had a significant effect on trust in government and self-efficacy. Moreover, these correlations were stronger when social media was used as a source for gathering information on COVID-19. In some cases, it even helped users avoid exposure to the virus. This study assessed the relationship between risk perception and the awareness gained from using social media during the pandemic and highlighted how social media usage influences trust in government and self-efficacy.
Socio-political activity of religious associations: clericalization and secularization
Authors:   Academy of Management of the Ministry of Internal Affairs of Russia, Denisova L. , Morozov А. ,   Omsk Academy of the Ministry of Internal Affairs of Russia
Published: January 2022

The authors investigate the content and results of the socio-political activity of religious associations in modern Russia. The appeal to this topic remains relevant due to the ambiguity of assessments of initiatives and activities of religious communities given in the humanities and social sciences. Quite naturally, the article mainly examines the socio-political activity of the Russian Orthodox Church of the Moscow Patriarchate (hereinafter - the ROC), as well as the positions of Islamic organizations, which is justified by the dominant position of Orthodoxy and Islam. The object of the study is the socio-political activity of religious associations in modern Russia. The subject of the study is the socio-political effects of the activities and public initiatives of religious associations in modern Russian conditions. The purpose of the article is to determine the nature of the influence of socio-political activity of religious associations on political processes in modern Russia. The objectives of the study are to: – determine the validity of statements about the clericalization of socio-political life in modern Russia; – identify the trends in the socio-political life of Russia determined by public initiatives and the activities of religious associations; – establish the significance of the socio-political activity of religious associations for the socio-political life of modern Russia. Methodology and methods of research. The work was carried out on the basis of general scientific principles of objectivity, historicism using methods of analysis, synthesis, modeling. Formal logical procedures, methods of systematic and comparative legal analysis were also used. The degree of scientific development of the research topic. The socially significant activities of religious associations, especially the ROC, attract the attention of a wide range of authors. The significance of this activity is assessed in different contexts: political, socio-economic, cultural. Different authors come to conflicting conclusions, which creates the need to continue research. The authors of the article not only analyze the existing approaches to the consideration of the socio-political activity of religious associations, but also turn to the facts that create an empirical basis for their own conclusions. They establish that two multidirectional trends in the development of society - clericalization and secularization - to one degree or another can simultaneously be present in complex modern socio-political processes. However, they create a kind of variant of the relations of religion, state and politics
WAYS TO IMPROVE THE MANAGEMENT AND MONITORING SYSTEM OF HAZARDOUS CONSTRUCTION WASTE MANAGEMENT
Authors:   Vladimir State University, Batalov S.
Published: January 2022

Responsible waste management is an important aspect of sustainable construction. In this context, waste management means eliminating waste wherever possible; minimizing waste where possible; and reusing materials that might otherwise become waste. Solid waste management practices have shown that the reduction, recycling and reuse of waste is important for sustainable resource management. In this scientific work, the development of an organizational, technical and economic mechanism for managing the waste generated during construction is considered. The results of waste management and monitoring of hazardous waste management and objects of their formation are presented. The ways of solving the complex problem of optimizing and improving the efficiency of handling construction waste of destroyed buildings are proposed. The object of the research is hazardous construction waste. The subject of the study is the system of management and monitoring of hazardous waste management in construction. The purpose of the study is to scientifically substantiate possible options for improving the management and monitoring system for the management of hazardous construction waste. Research objectives: to analyze the most dangerous sources of environmental pollution by waste in the construction process, to develop recommendations for improving the management and monitoring system for the management of hazardous construction waste. Methodology and methods of the research. The methodological basis of the research is a set of scientific approaches and methods, including the analysis of scientific sources. The author concludes that in order to improve the management and monitoring system for the management of hazardous construction waste, it is recommended to develop a comprehensive program for the safe management of hazardous construction waste
Spatial development of Eastern Siberia: to the problem of construction of new cities
Authors:   East-Siberian State University of Technology and Management, Belomestnov V. , Belomestnov I. ,   FGKU Rosgranstroy
Published: January 2022

The article reveals the main approaches to the socio-economic and spatial development of regions and proves the need to combine them into an integrated approach to spatial socio-economic development. It is shown that both traditional economic resources and the use of innovations, social, environmental and other resources can act as a development base. The article considers the innovative-informational and natural-resource directions of economic development. The historically established approaches to the development of economic space are highlighted from the standpoint of realizing the advantages of territorial location and development, as well as from the standpoint of realizing the benefits of innovative entrepreneurial activity. Entrepreneurial (economic) activity was chosen as the main driving factor of development. The theory of the economic space development based on the use of economic, social and environmental potential in the general economic field of the region has been substantiated. The author’s concept of isopot is used as a tool for the formation of integration ties in the territory, which determines the transfer of financial, information, resource and other flows within the framework of the implementation of development strategy projects and provides spatial socio-economic planning. The typification of development has been carried out depending on the orientation towards the resource-raw material, industrial-innovative, agrarian-innovative, social-service and communication-logistic components of the potential. The resource-raw material, transport-communication, ecosystem, socio-cultural, innovation-cluster and political-economic (military-political) approaches to the spatial socio-economic development of regions have been determined. The axial, network and cluster placement models for spatial development are considered. The initiative of building new cities of scientific and industrial type in Eastern Siberia is considered. The analysis of this project’s goals, the prerequisites for its appearance is given. The historical trends of changes in the incentives for the construction of new cities are analyzed. The features of the technological specialization of new cities, transport, personnel and financial support are revealed. The main problems of the project are shown. The alternatives to the construction of new cities are considered. The necessary stages of transformation of the state vision of economic development from the economy of slogans and appeals, through an irrational economy to a rational economy, have been investigated
DEVELOPMENT OF A BUSINESS PROCESS MODEL FOR AUTOMATED MONITORING OF FINANCIAL OPERATIONS BY THE BANK TO COUNTER LEGALIZATION OF CRIMINAL INCOME
Authors: Lyeonov S. , Kuzmenko O. , Koibichuk V. , Kushnerov O.
Published: January 2022

The general architecture of the automated information system of financial monitoring consisting of 4 levels is developed in the article: internal financial monitoring of economic agents (level 1), bank financial monitoring (Client-bank - level 2), state financial monitoring ( level 3), law enforcement and intelligence organs (level 4). The model was developed using the Bizagi Studio software product and modern BPMN 2.0 notation for automated monitoring of the business process of financial transactions through the "Client-Bank" system, which reveals the purpose and subject of the study. Relevant criteria for verifying the content of financial transactions are 10 factors unified for different economic agents and 13 verification criteria implemented directly at the second level of verification in the system "Client-Bank." The paper confirms that to implement an effective and efficient system of response to any alarming or suspicious actions related to financial transactions, it is necessary to use automated financial monitoring systems, conducting internal audits of economic agents' financial transactions to achieve quality monitoring in the "Client-Bank" system. This allows making the identification of potential threats with a high degree of probability. If there is a noncompliance with any of the verification criteria, the automated system of verification of financial transactions generates messages to the services of state financial monitoring, law enforcement, and intelligence agencies. The results of the developed business process models of the automatic system for internal monitoring of economic agents and the automatic business process monitoring of financial transactions by the bank can be implemented in the work of primary financial monitoring entities, directly, into the banks, credit unions, pawnshops, insurance companies, other financial institutions, and payment institutions and organizations.
ARTISTIC VERSIONS OF THE PROBLEM OF NATIONAL IDENTITY IN THE WORKS OF ASKOLD MELNYCHUK
Authors: Bokshan Halyna
Published: January 2022

literary interpretation of the problem of national identity in A. Melnychuk’s novels “What is told” and “Ambassador of the Dead” and identify correlation of the models of ethnic self-determination with the characters of these works. The paper mainly focuses on the features of the writer’s literary embodiment of the models of national identity, substantiated by V. Aheieva, one of which is based on the idea of its immutability, the other one implies the possibility of an individual choice. It examines the challenges for national identity under conditions of emigration, outlined by the author in the novels “What is told” and “Ambassador of the Dead”. The study establishes that the character creation in A. Melnychuk’s works reflects unchangeable national and cultural self-determination of some heroes and evolution of its components through other personages, that illustrates V. Aheieva’s statement with respect to the modern ideas about this problem. It emphasizes the correlation of the motifs of national identity and historical memory, manifesting itself in both novels with regard to particular characters and the collective figure of the Ukrainian community in the USA. The research finds out that in both A. Melnychuk’s novels there are two polar models of national self-determination: some characters represent those who persistently cherish and maintain inherited identity (Zenon Zabobon and his daughter Slava; Adriana Kruk), whereas other heroes demonstrate flexibility, and willingness to assimilate in a new environment, defending their right to make an individual choice (Arkadii Voroh and Natalka Zabobon; the poet Anton, Alex Kruk and the narrator Nick Blud).
Human Capital Quality Assurance under the Conditions of Digital Business Transformation and COVID-19 Impact
Authors: Antonyuk Nataliya , Plikus Iryna , Jammal Mohammad
Published: January 2022

This article addresses human capital quality and development analysis under the digital transformation and economic changes effected by the COVID-19 pandemic. The primary goal of this study is to justify the theoretical and methodological provisions for developing an environment of innovation, assuring the digitalization of society through innovation activity of economic entities and human capital development by ensuring its quality under the COVID-19. The theoretical and methodological basis of the study involved the systematic approach, comparative method, statistical analysis. The foresight principles were applied for quantitative and qualitative monitoring of innovation and human capital policy measures through preventive work with information and official documents concerning the digital transformation, development of innovative economy, and human capital. In the study frameworks, the authors analyzed the scientific sources addressing the investigated topic. The search for relevant publications was conducted in the scientometric databases Google Scholar, Web of Science, EBSCO, and others. For comparing the frequency of search requests under the determined research keywords, this study involved the instruments of the online search engine Google Ngram Viewer. The sources of information are the European Union website and the State Statistics Service of Ukraine, analytical reviews, reports, and forecasts by leading consulting companies. Based on the treatment of the world forecasts and analytical reviews, the study determined the development directions of an innovative economy and human capital considering an educational and scientific policy. The main study results stated the necessity to improve the human mental capacity due to keeping the work and rest arrangements. Therefore, it needs pharmacological recommendations and other measures to improve mental capacity as key criteria for human capital quality. The study results were validated within the framework of expert discussions at scientific and practical conferences and round tables with representatives of leading enterprises and universities. The authors developed several proposals to deal with identified problems and challenges.
Necessary Transformation of Administration for Family Physicians Practice
Authors: Pokhylko Svitlana , Nikitin Yurii
Published: January 2022

This paper considers the internationally leading models in administration work of family physicians, such as traditional care in outpatient clinics, disease control programs, and human-centered primary health care. The authors noted that the Ukrainian model of «human-oriented health care» is being confidently formed under the health care modernization and EU integration process. The authors found the reducing number of hospitalizations of the catchment population; decreasing mortality at home with cardiovascular disease, tuberculosis, diabetes; reducing the congenital malformations of children undetected during their mothers’ pregnancy. In addition, the study detected the growth of the visit number of the catchment population to the healthcare facilities for preventive purposes; an expanding the nursing of the number of one-year-old children; no cases of child deaths at home, etc. The findings showed that the process of administrative control and evaluation of the effectiveness of family physicians should be based on clearly defined criteria. Each head of the health care facility could set their own requirements for the effectiveness of primary care physicians. The specification of certain indicators for assessing the effectiveness of the family physicians covers the number, density, age, and sex of the population, morbidity, geographical and other characteristics. However, the lack of uniform requirements for administrative control and evaluation of the work of family physicians complicates the process of administering the work of primary care physicians, which needs to be further addressed. The article aims to analyze the effectiveness of the administration of family physicians in the Municipal non-profit enterprise of Konotop City Council «Konotop Municipal Hospital». The main problems and directions of improving the efficiency of administration of family physicians were highlighted. It was established that the most significant shortcomings were the absence of a website; insufficient number of practicing family physicians; dissatisfaction with wages; insufficient level of logistics; insufficient level of practical training of young specialists, etc. Family physicians also noted difficulties in the transition from working with paper documents to digital ones and weak Internet and poor performance of relevant servers. In turn, that affects the entire process of family physicians from the moment of registration (via the Internet or by phone) to the issuance of electronic prescriptions for medicines or sick leaves. Based on the study results, several recommendations were made to family physicians and hospital administration to increase their work efficiency.
Vaccination Management Process and Challenges: Case of Bangladesh
Authors: Md Fahim Ahmed Kazi
Published: January 2022

The world is fighting an unexpected event of a pandemic. All over the world, people are living in fear of health of their own or family or the society World Health Origination says vaccination is the only solution to get rid of this COVID-19 pandemic. Vaccination needs effective and efficient management. Bangladesh, a developing South Asia with around 170 million population, is at high risk. On 8 March 2020, the first case of COVID-19 officially declared 1,580,559 confirmed cases and 28,041 deaths till now. This study aims to investigate and review the management and associated challenges of COVID19 vaccination in Bangladesh. The study will review various existing literature including research articles, newspapers, government statements. The article will criticize the management efforts in different stages of the process. The scientific papers and renowned national and international newspaper articles are considered for examining the literature. The scope of the research kept limited to the extent management and challenges of COVID-19 vaccination of Bangladesh are relevant. This will be a basis to conduct further researches to know in-depth. This study also criticizes the fact that the government was not much in favor of taking suggestions from external bodies like UK Research and Innovation (UKRI) and the Centre for Disease Control and Prevention (CDC), which could improve and handle the situation in a much efficient way. The study dissects the whole COVID-19 vaccination of Bangladesh into significant e segments. It tries to appreciate the good initiatives while denouncing the poor actions. It contributes by anatomizing, cherishing, and criticizing the management actions to bring attention to these points and develop the vaccine management process. It will help identify the flaws in the strategic implication of procuring the vaccine, which will further hint for the authority to consider arranging such initiatives. It will portray the lack of organizing and control, which is creating a chaotic situation in the vaccination campaign. Relevant authorities can consider the study to do further research to smooth the management process. As a result, the resources will the effectively used and efficiency will be ensured as the process will speed up.
Age discursive practices in electronic media news
Authors: Balandina Nadiya , Pankevych Olena
Published: January 2022

The purpose of the investigation is to identify discriminatory gerontophobic practices in the news of electronic media and to illustrate the multi-vector discursive field of ageism. The content analysis allowed to establish the specifics of gerontological ageism, in particular its institutional nature, the presence of open and latent forms, which contributes to the spread of gerontophobia. This occurs as a result of age exclusion – the process of alienation from social and economic life, reduction of social roles through the use of such discriminatory practices as biomedicalization, marginalization, invisibilization, infantilization, dehumanization, trivialization, patronage. Among these practices are traditional, deep into antiquity, and operational, adjusted to modern realities. The media disseminate what is in society, and hence, determine what attitude to old age is cultivated in the mass consciousness.
Linking ecohydraulic simulation and optimization system for mitigating economic and environmental losses of reservoirs
Authors: Sedighkia Mahdi , Datta Bithin , Fathi Zeynab
Published: January 2022

Balancing the benefits and environmental degradations of the reservoirs is a challenging issue in the reservoir management. The present study proposes and evaluates an integrated framework to optimize reservoir operation in which hydropower loss and economic loss of irrigation supply are minimized while ecological degradations at downstream river are alleviated. The ecohydraulic simulation was utilized in the structure of the reservoir operation optimization. Reservoir operation losses and environmental degradations were minimized in three hydrological conditions including dry years, normal years and wet years. Moreover, the cropping pattern optimization was applied to mitigate the economic loss of irrigation supply as the main responsibility of the reservoir in the study area. Particle swarm optimization was applied in the reservoir operation optimization. Based on the results in the case study, reliability indices of hydropower production and farmers’ revenue are 15–25 and 30–60%, respectively. Moreover, the physical habitat loss is considerably reduced in all hydrologic conditions by proposing optimal environmental flow. The proposed method is able to provide a fair balance between downstream environmental degradations and economic benefits of the reservoir including farmers’ revenue and hydropower production. Low computational complexities are the most important strength point for the developed model.
The effect of three types of aquatic plants on water purification and removal of cadmium under different salinity conditions in northwestern Iran
Authors: Sufian Jafar , Golchin Ahmad , Avanes Armen , Moradi Salahedin
Published: January 2022

Phytoremediation is a high-performance and cost-effective approach to clean up contaminated water. This study aimed to investigate the rate of cadmium (Cd) uptake and changes in absorption of other elements using different plants at different cadmium concentrations under salinity conditions. This study was performed as a factorial experiment in a completely randomized design with three replications at Zanjan University located in northwestern Iran. For this purpose, three aquatic plants, Azolla Caroliniana, Watercress, and Duckweed, were used. In these experiments, different levels of Cd (0, 5, 10, 20, 40, and 80 mg L−1) in the nutrient solution as well as different NaCl concentrations (0, 10, 20, 40 and 80 mM L−1) were employed. After producing nutrient solutions with salinity and different Cd concentrations, three plants were grown in them for 30 days. The absorption of different elements such as Cd, Fe, Mn, Zn, Cu, N, P, K, Ca, Mg, and Na was measured in the plants. The results showed that the studied plants absorbed high concentrations of Cd. It was also concluded that the salinity of nutrient solution directly relates to Cd concentration in the plant tissues. The highest concentration of Cd in Azolla Caroliniana in 40 mg Cd and 80 mM NaCl was obtained with an average of 3,470.8 mg kg−1. In general, the results showed that the use of all three plants is suitable for purifying Cd-contaminated water.
Modeling and optimization of process parametric interaction during high-rate anaerobic digestion of recycled paper mill wastewater using the response surface methodology
Authors: Zwain Haider M. , Barghash Hind , Vakili Mohammadtaghi , Sh. Majdi Hasan , Dahlan Irvan
Published: January 2022

This study carried out the anaerobic digestion of recycled paper mill wastewater (RPMW) in a high-rate novel anaerobic baffled reactor. The parametric interaction between influent chemical oxygen demand (CODin) and hydraulic retention time (HRT) was modeled, and process responses were optimized by the response surface methodology (RSM) using a three-level factorial design. The results showed that the optimal condition was determined at CODin of 4,000 mg/L and HRT of 2 days and predicted values for COD removal, biochemical oxygen demand (BOD) removal, lignin removal, CH4 content, and CH4 production were found to be 94%, 98%, 68%, 85%, and 20.8 L CH4/d, respectively. According to the statistical analysis of the RSM, all models were significant with very low probability values (from 0.0045 to <0.0001). The parametric interaction showed that increasing the CODin positively influenced the COD, BOD, and lignin removal efficiencies, effluent alkalinity, and methane content and production but was unfavorable for pH and effluent volatile fatty acid (VFA). Shortening the HRT negatively affected the COD, BOD, and lignin removal efficiencies, pH level, alkalinity, and methane content and production, and increased the VFA effluent concentration. The optimal conditions were established at 4,000 mg/L COD and HRT of 2 days, corresponding to the predicted COD, BOD, and lignin removal efficiencies of 91, 98, and 71%, respectively, whereas 28 mg/L of VFA and 0.125 L of CH4/g CODremoved were generated.
An evolution of statistical pipe failure models for drinking water networks: a targeted review
Authors: Barton N. A. , Hallett S. H. , Jude S. R. , Tran T. H.
Published: January 2022

The use of statistical models to predict pipe failures has become an important tool for proactive management of drinking water networks. This targeted review provides an overview of the evolution of existing statistical models, grouped into three categories: deterministic, probabilistic and machine learning. The main advantage of deterministic models is simplicity and relatively minimal data requirements. Deterministic models predicting failure rates for the network or large groups of pipes perform well. These models are also useful for shorter prediction intervals that describe the influences of seasonality. Probabilistic models can accommodate randomness and are useful for predicting time-to-failure, interarrival times and the probability of failure. Probability models are useful for individual pipe models. Generally, machine learning approaches describe large complex data more accurately and can improve predictions for individual pipe failure models yet is complex and requires expert knowledge. Non-parametric models are better suited to the non-linear relationships between pipe failure variables. Census data and socio-economic data require further research. Choosing the most appropriate statistical model requires careful consideration of the type of variables, prediction interval, spatial level, response type and level of inference required.