bluuebunny/crossref_metadata_2025 huggingface dataset:
Gapped phases with non-invertible symmetries: (1+1)d
Authors: Bhardwaj Lakshya , Bottini Lea E. , Pajer Daniel , Schäfer-Nameki Sakura
Published: January 2025

We propose a general framework to characterize gapped infra-red (IR) phases of theories with non-invertible (or categorical) symmetries. In this paper we focus on (1+1)d gapped phases with fusion category symmetries. The approach that we propose uses the Symmetry Topological Field Theory (SymTFT) as a key input: associated to a field theory in dd spacetime dimensions, the SymTFT lives in one dimension higher and admits a gapped boundary, which realizes the categorical symmetries. It also admits a second, physical, boundary, which is generically not gapped. Upon interval compactification of the SymTFT by colliding the gapped and physical boundaries, we regain the original theory. In this paper, we realize gapped symmetric phases by choosing the physical boundary to be a gapped boundary condition as well. This set-up provides computational power to determine the number of vacua, the symmetry breaking pattern, and the action of the symmetry on the vacua. The SymTFT also manifestly encodes the order parameters for these gapped phases, thus providing a generalized, categorical Landau paradigm for (1+1)d gapped phases. We find that for non-invertible symmetries the order parameters involve multiplets containing both untwisted and twisted sector local operators, and hence can be interpreted as mixtures of conventional and string order parameters. We also observe that spontaneous breaking of non-invertible symmetries can lead to vacua that are physically distinguishable: unlike the standard symmetries described by groups, non-invertible symmetries can have different actions on different vacua of an irreducible gapped phase. This leads to the presence of relative Euler terms between physically distinct vacua. Along with the physical description of symmetric gapped phases, we also provide a mathematical one as pivotal 2-functors whose source 2-category is the delooping of the fusion category characterizing the symmetry and the target 2-category is the Euler completion of 2-vector spaces.
Universality of the close packing properties and markers of isotropic-to-tetratic crossover in quasi-one-dimensional superdisk fluid
Authors: Mizani Sakineh , Oettel Martin , Gurin Péter , Varga Szabolcs
Published: January 2025

We study equilibrium states and ordering regimes of a quasi-one-dimensional system of hard superdisks (anisotropic particles interpolating between disks and squares) where the centers of the particles are constrained to move on a line. A continuous change from a quasi-isotropic to a tetratic regime is found upon increasing the density. Somewhat unexpected, for isobaric states, systems with larger and more anisotropic particles in the tetratic regime are denser than systems with smaller and less anisotropic particles in a quasi-isotropic regime. Close packing behaviour is characterised by exponents describing the behaviour of the pressure, the angular fluctuations and the angular correlation length. We obtain two universal, shape-independent relations between them.
Neurofeedback-driven Emotional Regulation Training in a virtual reality environment: a machine learning approach using OpenBCI
Authors: Camelo Roa Sandra Milena , Rodríguez Belman Jahir
Published: January 2025

This paper addresses the design and development of an advanced neurofeedback system for training in emotional regulation skills and competencies; the system integrates a Virtual Reality (VR) platform with a 16-channel OpenBCI device for real-time capture of electroencephalographic (EEG) signals. The main objective of the research lies in the application of machine learning algorithms, specifically Random Forest and K-Nearest Neighbors (KNN), for the classification of emotional states in terms of valence and arousal. These algorithms achieve an accuracy of up to 83% for arousal classification and 90% for valence. EEG signals are processed and classified in real time and the results are integrated into a virtual reality environment created in Unity. This adaptive environment changes according to the detected emotional states, allowing for more precise regulation. In addition, a diaphragmatic breathing protocol has been developed within the virtual reality environment as an intervention strategy for emotional regulation. The system is in its final stage of piloting to establish the efficacy of the system.
Afetividade, reconhecimento e menosprezo na cotidianidade de pessoas acompanhadas por um serviço de saúde mental em Brasil
Authors: Lima da Silva Isis , Patiño Orozco Rafael Andrés
Published: January 2025

A Modernidade inaugurou uma nova forma de conceber a loucura como doença, confinando as pessoas diagnosticadas com transtornos mentais em hospícios e manicômios. Fruto de questionamentos a essas práticas de institucionalização, novas estratégicas de cuidado em saúde mental surgiram na segunda metade do século XX. Apesar dos avanços, as pessoas diagnosticadas com transtornos mentais ainda são submetidas a práticas de menosprezo e exclusão social na cotidianidade. Neste trabalho discutimos experiências de reconhecimento e menosprezo, entre usuários de um CAPS II na Bahia, usando o método da foto-provocação. Entre os resultados, destacamos que as experiências de menosprezo ferem a autoestima, enquanto o reconhecimento afetivo contribui para o fortalecimento da autoimagem positiva e a possibilidade de exercício da cidadania. Assim, vínculos fundamentados na dedicação amorosa fortalecem a autonomia e facilitam laços sociais baseados na confiança e no respeito, que contribuem nos processos de cuidado em saúde mental.
INVESTIGATION OF THE IMPACT OF NATURAL ANTIOXIDANTS FOUND IN COFFEE LEAVES, YERBA MATE, AND JAMBOLAN PULP ON THE INDUCTION PERIOD AND RATE CONSTANT OF BIODIESEL OXIDATION REACTION IN THE PRESENCE OF METALLIC IONS
Authors: G. Branco Isadora , W. Campos Julia , G. de Sousa Eduardo , F. Silva Nathan , Gonçales Filho José , Pauli Elis , S. Romagnoli Érica , G. Mantovani Ana C. , Borsato Dionisio
Published: January 2025

The present study describes the antioxidant potential of ethanolic extracts of yerba mate (Ilex paraguariensis), coffee leaves (Coffea arabica) and jambolan pulp (Syzygium cumini Lamarck) when added to biodiesel, with and without chromium (Cr3+), manganese (Mn2+) and cobalt (Co2+) metal ions, measuring the induction period (IP) and the rate constant (k) of the oxidation reaction at 110 °C. Antioxidant activity was observed in all extracts, as they reduced k and increased the IP compared to the control sample. The coffee leaves extract had the most pronounced positive effect, increasing the IP to 12.42 h and reducing k by 5.9 times. However, biodiesel containing metallic ions of chromium, manganese and cobalt, both with and without natural extracts, reduced the IP in all assays conducted in this study. The natural yerba mate extract was the most affected by the manganese ion (Mn2+), reducing the IP by 41.61%. The chromium ion (Cr3+) had the least impact on the biodiesel oxidation process in the presence of coffee leaves extract, increasing the rate constant by 3.55%. Furthermore, the alcoholic jambolan pulp extract was the one that presented the best antioxidant properties in the presence of metal ions.
Symbolic capital: Interpretations and types
Authors: Demidova Marina V.
Published: January 2025

The modern intellectualization of labour has led to the emergence of a symbolic form of capital, the interpretations of which differ in meaning, which creates a problem of understanding both this phenomenon and social interaction. Therefore, the purpose of this work is to analyze and identify the most relevant definition of the concept of “symbolic capital”. The methodological basis of the study was made up of comparative and dialectical approaches implemented by analyzing the form and content of the concept under study, as well as in the dialectic of the development and existence of types of symbolic capital. The development of the hypothesis about the conditionality of various interpretations of the concept of “symbolic capital” by the authors’ research position is achieved by identifying various contexts of social interaction: economic (Zh. Baudrillard), general professional (informational) (E. Toffler) and social (P. Bourdieu). The article substantiates the position that the definition of the concept of “symbolic capital”, presented by P. Bourdieu in a social way, is the most accurate, general and relevant, since economics and professional activity are derived from social activity. Symbolic capital in the social interpretation made by P. Bourdieu reflects the empirical law of the functioning of society as a whole, since it establishes a regular process that characterizes social interaction in ontological aspects: mainly in the processes of structuring social interaction as a social exchange, recursive in nature. For the first time, six types of symbolic capital were identified: diffuse and objectified (P. Bourdieu), progressive and regressive, reflexive and nonreflexive (author’s), expressed in new concepts, which are defined. These types of symbolic capital as concepts have great methodological potential in determining the features and patterns of the functioning of the “symbolic capital” strategy. The results of the research can be applied in social theory and practice, social philosophy.
Speech Component in the Profession of Engineer (Based on a Survey of Technical University Students)
Authors:   Saint Petersburg Mining University, Stepushina Olga V.
Published: January 2025

The article deals with the speech science component in the engineering profession. The purpose of the article is to draw attention to the demand for speech science knowledge in the engineering profession; to study the ideas of students about the importance of the speech component in engineering education. The material for the article was the results of a survey that was conducted among 1st-2nd year students of Empress Catherine II Saint Petersburg Mining University. The survey participants expressed their position and argued their point of view, explaining why a good knowledge of the Russian language is / is not important in their profession. The article identifies four groups of reasons why future engineers consider a good knowledge of the Russian language to be in demand among engineering specialists. They are is an improvement in the quality of speech, the use of the Russian language for professional activities, taking into account the status characteristics of the language and the influence of the language on the level of communication skills. The article concludes that speech science knowledge is in demand in the training of engineers. The article notes that respondents demonstrate a pragmatic view of the role of the Russian language in the engineering profession (emphasis on literacy and business communication), pay attention to the status characteristics of the Russian language, associate good command of the Russian language with the level of education, note the importance of good speech training for the implementation of interpersonal communications. The survey results can be used in developing work programs in speech science disciplines and justifying the relevance of studying speech science disciplines at a technical university. The study of speech difficulties faced by technical university students when communicating in an educational and professional environment is identified as a promising direction for further scientific work on the topic.
Interpretation of Artistic Work in the Works by N. A. Rudyakov
Authors:   V. I. Vernadsky Crimean Federal University, Dorofeev Yuri V.
Published: January 2025

The article considers the main theoretical provisions of the theory of text as a tool for social interaction. The prospects for using the interpretation technique to solve a number of problems related to the study of the text, in particular for the formation of reading literacy skills, are outlined. The perception of the text, its understanding and interpretation are key skills for a modern person, so the development of a technique that ensures their formation is one of the priority tasks in domestic linguistics. The goal is to determine the features of the modern theory of text, using the original methodology for interpreting works of art in the works of N. A. Rudyakov, on the basis of which it is possible to build a methodology for the formation of reading literacy. The theory of text analyzed in the study takes into account the basic principles of text analysis developed in linguistics and ensures the development of a strict and typical method of text interpretation. This method has evidence based on the idea of the text as a functional system that is created and exists for a specific purpose. The methodology of N. A. Rudyakov is based on the thesis about the role in the text of the contradiction between the due and the given, which acts as a system-forming factor and is manifested in the correlation of linguistic means characteristic of a given work. Accordingly, the content of the text is considered from the position of its influence on the reader. The object of the study is the theoretical provisions of N. A. Rudyakov and the key characteristics of the text, identified by him within the framework of the proposed concept. The main idea of this article is the need to introduce into educational practice a methodology within which work with texts is oriented towards effective social interaction and the formation of reading literacy skills.
“Our Everything”: Pushkin and Not Only Him
Authors:   V. V. Vinogradov Russian Language Institute of the Russian Academy of Sciences, Severskaya Olga I.
Published: January 2025

The article examines the semantics of the idiom nashe vsyo (‘our everything’), which entered the Russian cultural and linguistic consciousness and speech as a reflex of the Apollon A. Grigoriev’s statement: “Pushkin is our everything”. The study, conducted on the basis of the Russian National Corpus (taking into account the data of the Main, Newspaper and the Social networks Corpuses) by the corpus method using the techniques of socio-cultural, linguacultural and contextual-semantic analysis, allowed the author to identify the range of meanings of the idiom and determine the models of its structural transformation. Having studied the texts of the 18th‑19th centuries, the author discovers stable combinations nashe vsyo, nash ves,, nashe vsyo X in the syntactic function of defining the subject of speech and suggests that they could serve as a prototype of the idiom in its predicative meaning, which was first recorded in the Grigoriev’s aphorism. The history of the study of the semantics of the idiom is highlighted, attention is drawn to its lexicographic fixation. The article analyzes the reflexes of the idiom in different types of modern discourse (fiction, journalism, social networks, memes and demotivators, Internet folklore). The author comes to the conclusion that all these reflexes are somehow connected with the Pushkin myth and the concepts of “Russia”, “people”, “soul”, “literature”, “language”, “speech”, “genius”, “pride”, “necessity” emphasized by Grigoriev as a first narrator. Contextual-semantic analysis allowed to identify the meanings of “Pushkin”, “genius”, “outstanding talent”, “something important, significant, essential for the speaker”, which are connected with the idiom nashe vsyo ‘our everything’ today. The author also analyzes the structural and semantic transformations of the idiom, the most common of which are “Pushkin is our X” and “X is our everything”.
On Definition of Concepts “Fairy Tale” and “Magic Fairy Tale”
Authors:   Irkutsk State University, Kaplunenko Alexandra Y. , Brikova Ekaterina V. ,   Irkutsk State University, Kaverzina Anastasiya V. ,   RUDN University
Published: January 2025

The article addresses the definitions of “fairy tale” and “magic fairy tale” within the context of Vladimir Propp’s morphology of the magic folktale. It delves into the observations made by numerous scholars regarding the structural similarities in fairy tale narratives, such as Carl Gustav Jung’s attribution of fairy tales to the collective unconscious and Alexander Veselovsky’s attempts to identify narrative structures. Critiques of existing classifications, which permitted the categorization of a single fairy tale into multiple categories simultaneously, provided the groundwork for Vladimir Propp to derive a sequence of events-functions through the analysis of a corpus of fairy tales. This sequence of 31 event-functions subsequently formed a distinct class of magic tales, defined by the adherence to established order. However, Propp himself acknowledges the potential inclusion of other works, such as myths, legends, and chivalric novels, within this category. Within the scope of this article, efforts are made to define the features of the genre “fairy tale” and to contemplate an alternative name for one of its classes, namely “magic fairy tale.” The necessity for a different name for the class of “magic fairy tales” arises from Propp’s observation that the term “magic” may not fully align with the content, considering the existence of fairy tales devoid of magical elements. Through the analysis of classical fairy tales from various cultural backgrounds, the main objectives of fairy tale narratives are identified: entertainment, education, preservation and transmission of cultural values, teaching of native languages, and cultivation of aesthetic sense. Additionally, characteristic features are revealed that aid in distinguishing prototypical fairy tales from other genres within Vladimir Propp’s morphology.
Assessment of naturally occurring radionuclides in the coastal sediment with statistical analysis of radiological risk parameters
Authors: Pandion Kumar , Arunachalam Kantha Deivi , Gaafar Abdel-Rhman Z. , Almunqedhi Bandar M. , Kuppusamy Sowmya , Singh Rajeev Pratap , Chandrasekaran Murugesan , Dowlath Mohammed Junaid Hussain , Chang Soon Woong , Balasubramani Ravindran
Published: January 2025

This study reports on the spatial distributions of naturally occurring 238U, 232Th, 40K, 222Rn, and 220Rn from sediments across the coastal zone of the Bay of Bengal (BoB). The mean values of 238U, 232Th, and 40K activity are 23.42, 80.95, and 292.49 Bq kg−1, and the 220Rn surface mass exhalation rate value of 1,225.33 was calculated by 2.54 mBq kg−1h−1. The radionuclide concentration range in all the samples estimated in the coastal region was 220Rn > 40K > 232Th > 238U and the radiological risk parameters (Raeq, DR, AEDE, AGDE, Iɤr, AUI, Hex, Hin, and ELCR) were higher in the Kanyakumari region and lower in the Puducherry region of the BoB. The radionuclide levels of 232Th, 238U, and 220Rn displayed a strong step of positive association with all parameters of radiological hazards through constants of r > 0.75. This showed that radiation risks were correlated with, and regulated by, 238U and 232Th concentrations. Therefore, coastline sediments do not pose any serious hazard, and the statistics obtained from this analysis will serve as the reference data for the activity of natural radionuclides in sediments across the coastal zone of the BoB.
Simulation and prediction of hydraulic jump characteristics over expanding rough beds using FLOW-3D and soft computing techniques
Authors: Ziari Morteza , Karami Hojat , Ostadi Ali , Ghazvinian Hamidreza
Published: January 2025

In this study, hydraulic jumps over expanding beds with artificial roughness were simulated using FLOW-3D across Froude numbers ranging from 4.34 to 9.37. The simulations were conducted on both smooth and rough beds, with roughness in the form of half-spheres of 3, 4, and 5 cm in diameter, and divergence angles of 7°, 14°, and 90°. The results showed that for maximum discharge in a sudden divergent channel, a rough bed with 5-cm diameter elements reduced flow depth by 19.77% compared to a smooth bed. Additionally, in all scenarios, the ratio of y2/y1 increased as the Froude number increased. In the second phase, soft computing models – such as Linear Regression, Support Vector Regression, Decision Tree, Random Forest, Bagging, Gradient Boosting, MLP, and Stacking – were employed to model the relationships between input parameters (Fr1, θ, D/b1, and Kb) and outputs (y2/y1 and Lj/y1). The R2 coefficient value in the training stage of the Stacking model for the parameter (y2/y1) was 0.978 and in the testing stage it was 0.988, and for the parameter (Lj/y1) in the training and testing stages this coefficient was estimated to be 0.971 and 0.987, respectively.
Variação na densidade da madeira produzida na região semiárida submetida a diferentes regimes de irrigação
Authors:   , Santos Márcia Ellen Chagas dos
Published: January 2025

O presente trabalho teve como objetivo avaliar a qualidade da madeira de quatorze materiais genéticos (nove espécies, entre nativas e exóticas; e cinco clones de Eucalyptus), cultivados sob dois regimes de irrigação pós plantio no Semiárido brasileiro. Para cada genótipo foram selecionadas seis árvores, submetidos a dois regimes de irrigação inicial (até 12 meses; até 36 meses), ambos após o plantio com idade de aproximadamente 11 anos. Para a análise, foram retirados discos de diferentes alturas do fuste: 0% (base), altura do peito (DAP), 20%, 40%, 60%, 80% e 100%. Subamostras do disco nas posições radiais próximo à medula, intermediária e próximo à casca também foram coletadas e saturadas em água para realizar a determinação da densidade, estabelecida pelo método de deslocamento da água. Os sistemas de irrigação provocaram alterações no padrão de variação radial e longitudinal nos clones quanto a proporção de material lenhoso no fuste. Entre as espécies nativas, destacou-se o Angico com alta densidade e pouca madeira juvenil, e o Pau d’arco, com baixa densidade e alta taxa de madeira juvenil. Nas espécies exóticas, o Nim apresentou alta densidade e baixa taxa de madeira juvenil e o Chichá apresentou alta taxa de madeira juvenil e baixa densidade. Nos híbridos de Eucalyptus, se destacou o VE38 com densidade elevada e maior teor de material lenhoso. Ocorreu influência dos manejos de irrigação, observada com maior intensidade nas espécies exóticas para o Mogno e a Acácia, e para os clones de Eucalyptus VE41 e AEC1528. Os valores das densidades básicas nas árvores variaram no intervalo de 0,35 a 0,85 g.cm-3. Houve boa adaptação das espécies nativas, exóticas e dos clones à área de plantio na região Semiárida.
Ononin’s Antagonistic Activity towards TRPV1: Insights from Molecular Dynamics and Capsaicin-Evoked Calcium Response in DRG Neurons
Authors: Saqallah Fadi G. , Abbas Manal A. , AL-Najjar Belal O. , Al-Kabariti Aya Y. , Yusuf Muhammad , Abdulwahed Omar A. , Barakat Noor A. , Alsalem Mohammad
Published: January 2025

Background:

The search for effective painkillers has led to intensive research,
with a particular focus on the transient receptor potential vanilloid-1 (TRPV1)
channel as a possible target.

Methods:

One promising candidate is ononin, which is investigated for its binding with
TRPV1 through a 200-ns molecular dynamic simulation and analysed via root-meansquare
deviation (RMSD), root-mean-square fluctuation (RMSF), hydrogen-bond interactions,
radius of gyration (RadGyr), and MM-PBSA energy calculations. The results
were further validated experimentally via calcium imaging studies.

Results:

Molecular dynamics revealed that the ononin-TRPV1 complex achieved stable
binding within a remarkably short time of approximately 38 ns while maintaining the degree
of compactness of the receptor throughout a 200 ns simulation period. In contrast,
the capsazepine-TRPV1 complex displayed more significant structural deviations during
the whole simulation. Moreover, MM-PBSA energy calculations showed a relatively
strong binding affinity between ononin and TRPV1, mainly attributed to favourable hydrophobic
interactions. Pre-incubation of dorsal root ganglia (DRG) neurons with
ononin (1 and 10 μM) or capsazepine (10 μM) for 4 min prior to stimulation with capsaicin
significantly reduced capsaicin-evoked calcium responses. No significant difference
between capsazepine and ononin was found at a concentration of 10 μM.

Conclusion:

Overall, this research demonstrates the potential of ononin as a potential antagonist
for developing analgesics targeting TRPV1. Hence, and to our best knowledge,
this study represents the first report of ononin’s antagonistic activity towards TRPV1.
Exploring the Mechanism of Shi-San-Wei-He-Zhong-Wan in the Treatment of Functional Dyspepsia Based on Network Pharmacology and Experimental Validation
Authors: Li Xiao Min , Zhu Jing Wei , Li Kui Wu , Han Xiao Yu , Ruan Jing Ru , Chu Hao Ran
Published: January 2025

Purpose:

The incidence of Functional Dyspepsia (FD) is gradually increasing, yet
there are currently no effective treatment methods available. This study explored the effective
components, potential targets, and pathways of Shi-San-Wei-He-Zhong-Wan (SSWHZW) in the
treatment of FD, aiming to provide new insights into its treatment.

Methods:

First, the Chinese Medicine System Pharmacology Database and Analysis Platform
(TCMSP) and GeneCards databases were utilized to identify the major active components of
SSWHZW and potential therapeutic targets of FD. Subsequently, functional enrichment analyses
were performed to elucidate the mechanisms of SSWHZW on FD. Molecular docking simulations
were then conducted to assess the binding affinity of key targets and major active components.
Next, an FD animal model was established, and the therapeutic effects of SSWHZW were
validated using Hematoxylin and Eosin (HE) staining and Enzyme-linked Immunosorbent Assay
(ELISA). Finally, Western blot analysis was performed to validate the involvement of key signaling
pathways.

Results:

A total of 229 active ingredients and 283 putative targets were identified from
SSWHZW, of which 173 overlapped with the targets of FD and were considered potential therapeutic
targets. Key ingredients, such as quercetin, kaempferol, wogonin, and baicalein, were
identified as pivotal components of SSWHZW, potentially acting on the 173 overlapping targets
and influencing FD through related signaling pathways. Functional enrichment analysis revealed
that the PI3K-Akt signaling pathway, VEGF signaling pathway, and NF-kappa B signaling
pathway may be involved in the mechanism of SSWHZW in treating FD. Molecular docking
predicted that all five ingredients could firmly bind with the top-ranked target TP53 in the Protein-
protein Interaction (PPI) network. Further experiments demonstrated that SSWHZW protected
the intestinal tissues of FD rats from inflammatory damage by inhibiting the PI3K/AKT
signaling pathway.

Conclusion:

Based on network pharmacology, this study explored the multi-component, multitarget,
and multi-pathway characteristics of SSWHZW in treating FD. The findings suggest that
SSWHZW exerts its anti-FD effects by inhibiting the expression of the PI3K/AKT signaling
pathway, providing new insights and methods for further research on the mechanism of
SSWHZW in treating FD.
Artificial Intelligence Revolution in Pharmaceutical Sciences: Advancements, Clinical Impacts, and Applications
Authors: Halagali Praveen , Nayak Devika , Seenivasan Raagul , Manikkath Jyothsna , Rathnanand Mahalaxmi , Tippavajhala Vamshi Krishna
Published: January 2025

Artificial intelligence (AI) is a rapidly transforming drug discovery and development
process, significantly impacting the pharmaceutical industry and enhancing human
health. This review article examines the tremendous role of AI in analyzing complex biological
data, optimizing research processes, and reducing costs of production. Implementation of
AI in the pharmaceutical sector can store a vast dataset of manufacturing processes, identify
potential disease targets, simulate physiological conditions, and predict drug interactions. The
review article also discusses the AI concepts and their applications, particularly in developing
solid dosage forms. Advanced algorithms optimize formulation processes, predict pharmacokinetics
profiles, and assess drug toxicity profiles, facilitating a more efficient pathway from
pilot study to market. Additionally, this review highlights the advancements in 3D printing
technologies of dosage forms that have the ability to provide personalized treatment to different
individuals. Furthermore, the article explores the opportunities and challenges of AI in
healthcare, focusing on applications such as disease diagnosis, digital therapy, and epidemic
forecasting. Prominent AI technologies like deep learning and neural networks are examined
for their roles in predicting outbreaks of diseases like influenza and COVID-19. As the pharmaceutical
landscape evolves, AI is poised to redefine traditional methods. This paves the way
for more efficient healthcare solutions. By harnessing the interplay of technology and science,
AI not only increases productivity; but it also promotes a new era of precision medicine tailored
to the needs of each patient.
Introducing the Concept of Hypertensive Heart Disease to Improve
Hypertensive Left Ventricular Hypertrophy
Authors: Koracevic Goran , Stojanovic Milovan , Zdravkovic Marija , Simic Dragan , Lovic Dragan , Djordjevic Dragan , Otasevic Suzana , Tomasevic Miloje , Sakac Dejan
Published: January 2025

Background:

Among the organ damage mediated by hypertension, cardiac lesions hold
significant importance. Numerous authors focus on hypertensive heart disease (HHD) rather than
exclusively on left ventricular hypertrophy (LVH).

Objective:

This narrative review aims to assess the incorporation of the concept of 'hypertensive heart disease' (HHD) in hypertension (HTN) guidelines. Furthermore, if HHD is not addressed, the review will evaluate the potential benefits of including this concept in future studies

Methods:

The following databases were searched: Scopus, Medline, Springer, Science Direct, Wiley,
SAGE, Cambridge, Oxford Journals, and Google Scholar. Attention was given to the guidelines related to hypertension(HTN); the search items were “guidelines” and “hypertension.” Within these
guidelines, we specifically sought references to ‘hypertensive heart disease.’

Results:

The concept of “HHD” is clearly advantageous compared to “HTN LVH,” as it not only
addresses LVH but also considers other structures of the heart that may be severely affected, which
can significantly influence treatment. The concept of “hypertensive heart disease” is mentioned in
only 8 out of 36 guidelines on HTN. The therapeutic implications and recommendations are absent in
the guidelines.

Conclusion:

The concept of HHD is reasonable and evidence-based, and there is no reason to focus
only on LVH when considering HTN-induced damage to the heart. It is time to update our recommendations for heart treatment by using the phrase "Treatment of hypertensive heart disease" instead
of "Treatment of hypertensive LVH." This update can enhance our awareness of the need to improve
not only HTN LVH but the other parts of the heart as well.
A Review of the Antiviral Activity of Berberine
Authors: Forouzanfar Fatemeh , Meshkat Zahra
Published: January 2025

Berberine is an isoquinoline alkaloid with strong pharmacological activity such as analgesic,
antioxidant, neuroprotective, antivirus, anti-inflammatory, anti-seizure, anti-obesity, and hypolipidemic
effects. Accumulated evidence indicates berberine plays an inhibitory role against infection
of numerous viruses, including human immunodeficiency virus, respiratory syncytial virus, hepatitis
C virus, human papillomavirus, human cytomegalovirus, and influenza virus. Berberine’s antiviral
action has shown promise, making it a viable option for synergistically enhancing the inhibitory effect
of current antiviral medicines. This review provides an overview of prior berberine antiviral studies
to prepare for its potential use as a natural antiviral agent in future research.
Synthesis and Anticancer Activity Evaluation of N-(3,4,5-
Trimethoxycinnamoyl)anthranilic Acid Derivatives
Authors: Duc Nguyen Tri-Thuc , Cam Phan Linh , Nguyen Dao Nhat-Linh , Phan Phuong-Thuy T. , Huynh Phan Da-Huong , Pham Tuan-Anh N.
Published: January 2025

There is an urgent need to search for more efficient, better-tolerated anticancer drugs. Tranilast, a synthetic analog of tryptophan metabolite, has been shown to inhibit the growth of various
cancer cells. In our previous study, the tranilast analog TRA01 [N-(3,4,5-
trimethoxycinnamoyl)anthranilic acid] was identified as a promising agent against the proliferation of
MCF-7 and HepG2 cell lines along with good binding affinity on the transforming growth factor beta
1 (TGFβ1) target. To further explore the structure-activity relationship, a series of N-(3,4,5-
trimethoxycinnamoyl)anthranilic acid derivatives (5a–i) were successfully synthesized via a two-step
synthetic procedure based on N-acylation and Knoevenagel-Doebner reactions and their structures
were determined using 1
H-NMR, 13C-NMR, and MS spectra. The derivatives (5a–i) were evaluated
for in vitro activity using MTT assay and in silico docking on TGFβ1 target by AutoDockTools–1.5.6
software. The bioactivity results of 5a–i showed 12.30–27.04% and 19.13–46.23% inhibition on proliferation of MCF-7 and HepG2 cell lines at 100 µM concentration, respectively, with the fluorinated
derivatives (5a and 5e) possessing the strongest inhibitory activities. The molecular docking also
found the best binding affinity of 5a (-8.70 Kcal/mol) and 5e (-8.71 Kcal/mol) on the TGFβ1 target.
The SAR result revealed that substituents on the benzene ring of anthranilic acid were not favored for
anticancer activity. Although these derivatives exhibited weak anticancer properties, the good binding
affinity to the TGFβ1 target suggested certain potential of this scaffold for further study on this target.
Diosmin as Antidiabetic Agent: A Comprehensive Mechanistic Approach
Authors: Jyoti Uma , Devi Sushma
Published: January 2025

Diabetes mellitus is a chronic metabolic disorder which occurs due to deficiency of
insulin or resistance to insulin receptor. There are naturally occurring compounds found in various
plants, foods, and herbs that have potent anti-diabetic properties. They help to control blood
sugar levels by increasing insulin sensitivity and stimulating glucose absorption in cells. Diosmin,
a flavonoid glycoside found primarily in citrus fruits, has shown outstanding potential as a therapeutic
agent due to its significant anti-diabetic, anti-inflammatory, antioxidant, and vascularprotective
properties. Here, we review the diosmin molecular mechanism and its ability to regulate
oxidative stress, reduce inflammatory cytokines, improve endothelial function, and explore
its pathway for anti-diabetic properties. In addition, preclinical and clinical data that supports diosmin
efficacy in decreasing blood glucose, enhancing insulin sensitivity, and delaying the development
of diabetic squeal was considered. Furthermore, diosmin has shown great potential in a
variety of therapeutic domains when associated with other drugs in combinational studies, and
many diosmin-based drug delivery studies have been reported. This review also investigates the
molecular processes and clinical uses of diosmin, emphasizing its therapeutic potential as an additional
drug in diabetes control through a comprehensive review of current studies.
Assessing the Removal of Ciprofloxacin from Aqueous Solutions by Basil Seed
Authors: Gul Taj , Jan Laiq , Shah Muhammad Tariq , Khan Jehangir , Khan Kiramat , . Awais , Khan Shahab , Ullah Sami , Fouad Dalia , Ataya Farid S.
Published: January 2025

Introduction:

This study introduces basil seeds as a novel, low-cost, and environmentally
friendly adsorbent for the removal of ciprofloxacin from aqueous solutions. The primary innovation
of this work lies in the use of readily available basil seeds, which have not been widely explored for
this purpose, to achieve high adsorption capacity and efficiency.

Method:

The adsorption process was systematically optimized by adjusting parameters such as time,
temperature, pH, and ciprofloxacin concentration, with results showing maximum adsorption at 40
minutes, 70°C, and pH 7. Additionally, the study investigates the influence of interfering factors like
competing ions and organic matter in water, providing a more realistic assessment of the material’s
effectiveness.

Result:

The findings demonstrate that basil seeds offer a promising alternative to conventional adsorbents,
presenting both environmental and economic advantages for water treatment applications.

Conclusion:

This work significantly advances current knowledge by proposing a sustainable solution
for pharmaceutical pollutant removal from contaminated water.

other:

.
Cyclic Lipopeptides as Selective Anticancer Agents: In vitro Efficacy on B16F10 Mouse Melanoma Cells
Authors: Hmedat Ali N. , Morejon Micjel C. , Rivera Daniel G. , Pantelic Nebojsa Đ. , Wessjohann Ludger A. , Kaluderovic Goran N.
Published: January 2025

Objective:

In this study, 25 synthetic cyclic lipopeptides (CLPs) were investigated for their anticancer
potential against mouse melanoma (B16F10) cells, human prostate cancer (PC-3), human colorectal adenocarcinoma
(HT-29) and mouse embryonic fibroblast (NIH3T3) cells.

Methods:

The cytotoxic activity of investigated compounds was evaluated using MTT and CV assays. In order to
examine the mechanism of action of the most potent compound cell cycle analysis, apoptosis assay, caspase activity,
CFSE and DHR staining, DAF-FM, autophagy and immunocytochemistry caspase-3 assays were performed.

Results:

During the fast screening, compound 9, was identified as prospective active CLP against B16F10 cell
line at 10 μM concentration. MTT and CV assays exhibited at least four times higher cytotoxic potential of 9
(IC50 = 8.4±1.3 μM, MTT; 10.6±1.1 μM, CV) in comparison to control drug natural occurring CLP surfactin
(IC50 = 50.3±0.6 μM, MTT; 40.4±0.3 μM, CV). The use of flow cytometry analysis confirmed that apoptosis
was involved in the death of B16F10 cells after treatment with 9, as demonstrated also by DAPI staining. Caspase
activity could be detected during cell death (ApoStat assay, immunocytochemistry caspase-3 assay). Compound 9
provokes enhancement of nitric oxide (NO) production in B16F10 cells but does not trigger ROS/RNS generation
or autophagy.

Conclusion:

The study highlights synthetic compound 9 superior tumor-specificity and potential as an anticancer
agent compared to surfactin and cisplatin. These findings could guide the development of more selective and less
harmful macrocyclic lipopeptides for cancer therapy.
Potentials of N-Acyl hydrazones Against Colorectal Cancer: A Mini Review
Authors: Mounika Darna , Pulla Sai Satya Sri , Sule Swapnil Anil , Alli Vidya Jyothi , Jadav Surender Singh
Published: January 2025

Colorectal cancer (CRC) is a malignant gastrointestinal tract disorder with high occurrence and mortality index and showing an upsurge. Standard therapies for treating CRC are surgery and chemotherapy. Despite
great effort in developing effective treatments, the progress is limited due to its relapse and recurrence. Prognosis
of metastatic CRC is always complicated. This condition can be evaded by a novel approach i.e., targeted therapy
which increases the survival rate in CRC patients by blocking important pathways and acting on immune checkpoints. Drugs with N-acyl hydrazones (NAH) are currently being employed treatment of infectious diseases and
disorders. NAH in combination with diverse heterocycles, natural product isolates are identified as interesting
CRC inhibitors under-explored. This review provides an overview of the existing CRC targeted compounds having acyl hydrazones, hydrazine, hydrazides moieties, and their underlying mechanisms towards different CRC
cell lines, together with a discussion of their limitations and future trends.
Fabrication with Characterization of Single-Walled Carbon Nanotube Thin Film Transistor (CNT-TFT) by Spin Coating Method for Flat Panel Display
Authors: Moorthy Vijai Meyyappan , Venkatesan R. , Srivastava Viranjay M.
Published: January 2025

Background:

Thin Film Transistors (TFTs) are increasingly prevalent electrical components
in display products, ranging from smartphones to diagonal flat panel TVs. The limitations in
existing TFT technologies, such as high-temperature processing, carrier mobility, lower ON/OFF
ratio, device mobility, and thermal stability, result in the search for new semiconductor materials
with superior properties.

Objective:

The main objective of this present work is to fabrícate the efficient Single-Walled Carbon
Nanotube Thin Film Transistor (TFT) for flat panel display.

Methods:

Carbon Nano-Tubes (CNTs) are a promising semiconductor material for TFT devices due
to their one-dimensional structure and exceptional characteristics. In this research work, the CNTTFTs
have been fabricated using nano-fabrication techniques with a spin process. The fabricated devices
have been characterized for structural, morphological, and electrical characteristics.

Results:

The 20 μm channel length and 30 μm channel width fabricated device produces about 1.3
nA, which lies in the practical range of operating TFTs reported previously. Compared to reported
patents and published works, this demonstrates a significant improvement.

Conclusion:

Further guidelines and limitations of this fabrication method are also discussed for future
efficient device fabrication.
Medicinal Benefits of Frankincense: Future Approach to Effective Drug
Design
Authors: Lawati Abdullah Al , Waladwadi Tahlil , Alhabsi Ayman , Rawahi Nouf Al , Breiki Fatema Al , Lawati Meetham Al , Das Srijit
Published: January 2025

Frankincense is obtained from the tree, which belongs to the Bowellia family. Frankincense is found in China, India, Middle-East Asia, the Arabian Peninsula, and different parts of Africa. Incisions are given on the tree trunk to obtain the gum, which hardens to form frankincense. It
has been used as a traditional medicine to treat diarrhea, infection, tuberculosis, asthma, arthritis,
cancer, wounds, gingivitis, psoriasis, and other inflammatory conditions. Frankincense gum is used
for its aromatic properties and fragrance. Frankincense contains essential oils, gum resins, alcohol,
and water-soluble resins. The chemical compounds present in the natural product and their yield
depend on various factors such as geographical location, the surface area of the wood, climatic conditions in which it is grown, the age of the tree, and the methods of collection. Among the active
compounds, unique pentacyclic triterpene acids such as boswellic acid (BA) are present. The phytochemicals include β-boswellic acid, acetyl-β-boswellic acid (ABA), 11-keto-β-boswellic acid
(KBA), and 3-acetyl-11-keto-β-boswellic acid (AKBA) form the major components. BA possesses
anti-inflammatory action due to its control of cytokine production. The active compounds in frankincense act on 5-lipooxygenase and cyclooxygenase, thereby producing an anti-inflammatory effect.
We discuss the role of frankincense on the integumentary, nervous, cardiovascular, respiratory, digestive, endocrine, musculoskeletal, and immune systems with special emphasis on the molecular
basis of action and signaling pathways. Recent approaches in therapeutics by designing new
nanoformulations of frankincense may be beneficial for better drug delivery to the desired site, help
in controlled release, increase solubility and bioavailability, and reduce toxicity.
Real-Time Analysis of Sensitive Data Security in Manuscript Transition
Authors: Firoz Farhat , Srivastava Jyoti , Al-Abbasi Fahad A. , Anwar Firoz
Published: January 2025

Background:

Cybersecurity requirements for ensuring data security during research
manuscript transit on the journal website require continuous improvement and adherence to
best practices. Research data loss can have significant negative consequences across multiple
dimensions including time and financial loss. The present research investigates security vulnerabilities during the real-time transit of manuscripts on a journal website.

Material and Methods:

Website Access: The journal website was accessed, and
manuscript components (main manuscript, figures, tables, graphical abstract, funding sources,
suggested reviewer, and cover letter) were uploaded.

Operating system:

Kali Linux, designed for penetration testing and security auditing was used.

Tools and software:

Nmap (Version 7.95-2) for network discovery and security auditing. Nikto
(2.5.0) for web server vulnerability scanning, and Tor (13.0.13) to anonymize web activities.
Firefox (127.0.2) as the web browser, and VMware Workstation with Kali Rolling (2023.2 in
a virtual environment.

Testing phase:

Initial upload of the manuscript and supplementary materials. Upload of figures,
tables, and graphical abstract. Inclusion of funding sources, suggested reviewers, and cover letter.

Data Collection and Analysis:

Initial upload of the manuscript and supplementary materials. Upload of figures,
tables, and graphical abstract. Inclusion of funding sources, suggested reviewers, and cover letter.
Data Collection and Analysis: Network traffic and potential vulnerabilities were monitored on
Nmap, Nikto, and Tor.
Activities were conducted in the virtual environment of VMware Workstation for controlled
and replicable setup.
Output measures: Identified and documented potential security gap or vulnerabilities leading to
data theft during manuscript transit.

Results:

An Nmap scan of XXXXXXXX.com (IP: yyyyyyyyyyy) revealed six open ports: 80
(HTTP Apache), 443 (SSL/SMTP Exim), 587 (SMTP Exim), 993 (IMAPS), and 995 (POP3S).
each server showed potential vulnerabilities. The scan took 86.15 seconds.

Conclusion:

The results demonstrate a high risk of exposing sensitive information due to open
ports, the presence of potentially outdated services, and the possibility of incomplete detection
due to filtered ports pose a high risk of sensitive data during manuscript transit on the website
of the journal
Method for determining the bed load discharge by the parameter of the average depth of the layer of moving materia
Authors: Zavarzin R. V. , Katolikov V. M.
Published: January 2025

The object of the study in this paper is the dunes form of transport of bed load in the channels of lowland navigable rivers. An accurate assessment of the bed load discharge is important when considering river morphology, conducting dredging and river regulation works to ensure navigational conditions, as well as when designing various engineering structures. This paper analyzes modern methods for measuring bed load discharge based on dune parameters. Considering the identified shortcomings and limitations of existing measurement methods, a new method for measuring bed load discharge is proposed. A distinguishing feature of the proposed method is the use of the average depth of the layer of moving material when determining bed load discharge. This parameter is defined as the ratio of the area of the moving material to the length of the moving material layer. Essentially, the moving material consists of dunes identified after filtering out minor bottom protrusions. The advantage of this method lies in using of the average depth of the moving material layer, which allows for all the dunes identified in the longitudinal profile to be accounted for when calculating the bed load discharge. The use of areal dune characteristics also enables the determination of bed load discharge in rivers where the bottom relief consists of deficit dunes.To confirm the effectiveness of this method, a series of experiments were conducted in the Channel Laboratory of the State Hydrological Institute in hydraulic flumes with a movable sand bed. The channel bedforms consisted of three-dimensional dunes. The flow regime in the flume was adjusted to replicate conditions typical of lowland navigable rivers. The experiments confirmed that even with the complex three-dimensional structure of the channel bedforms, the proposed method is highly accurate compared to existing methods.