bluuebunny/crossref_metadata_2025 huggingface dataset:
How can social needs impact on meaningful sports consumption?
Authors: Zhigang Wang , Kai Guo , Chao Wang , Hongyan Duan , Lei Zhang , Zhao Xue
Published: November 2022

The main goal of this study is to explore the drivers of meaningful sport consumption and its influence mechanism. In sports consumption, consumers not only seek hedonic value but also pursue to experience greater purpose and meaning in life, which is regarded as meaningful sports consumption. This study extends existing sports management literature by examining how social needs impact meaningful sports behavior with team affiliation, self-improvement, and self-esteem as mediators. Based on the questionnaire data collected from China, the empirical analysis results show that social needs have a significant positive impact on meaningful sports consumption behavior through the mediating effect of team affiliation and self-esteem motivation. However, self-improvement motivation does not have a mediating effect on the relationship between social needs and meaningful sports consumption. This study enriches the research content of sports consumption, adds research object of social needs, and expands the research scope of meaningful consumption by introducing meaningful sports consumption into the above domain.
Gender and contextual variations in self-perceived cognitive competence
Authors: Kuzyk Olivia , Gendron Alice , Lopez Luz Stella , Bukowski William M.
Published: November 2022

School performance and cognitive competence can be conceptualized as social and relational constructs. Thus, we expect their association to vary as a function of other socially-embedded variables which have proven meaningful in the academic domain. The present study takes a critical theory approach to assess gender-related and contextual variability in the association between peer-assessed school performance and self-perceived cognitive competence. The sample consisted of 719 preadolescents (M age = 9.5 years, range = 9 to 12.5 years) living in lower- and upper-middle-class neighborhoods in Montreal, Canada and Barranquilla, Columbia. Multigroup comparisons revealed that (a) peer-assessed school competence was more strongly associated with self-perceived cognitive competence for upper-middle-class than lower-middle-class participants from Barranquilla, whereas the opposite pattern was observed with Montreal participants, and (b) that the association between communal orientation and self-perceived cognitive competence was stronger for girls than for boys across the sample, especially in the upper-middle-class school in Montreal. These findings highlight the nuanced degree of gender differences in preadolescents’ perceived academic competence and emphasize the role of SES in shaping self-perceptions.
Effect of landscape design on depth perception in classical Chinese gardens: A quantitative analysis using virtual reality simulation
Authors: Zhu Haipeng , Gu Zongchao , Ohno Ryuzo , Kong Yuhang
Published: November 2022

It is common for visitors to have rich and varied experiences in the limited space of a classical Chinese garden. This leads to the sense that the garden’s scale is much larger than it really is. A main reason for this perceptual bias is the gardener’s manipulation of visual information. Most studies have discussed this phenomenon in terms of qualitative description with fragmented perspectives taken from static points, without considering ambient visual information or continuously changing observation points. A general question arises, then, on why depth perception can vary from one observation point to another along a garden path. To better understand the spatial experience in classical Chinese gardens, this study focused on variations in perceived depth among different observation points and aimed to identify influential visual information through psychophysical experimentation. As stimuli for the experiment, panoramic photos of Liu garden were taken from three positions at Lvyin Pavilion. Considering the effects of pictorial visual cues on depth perception, the photos were processed to create 18 kinds of stimuli (six image treatments * three positions). Two tasks were presented to the participants. In Task 1, 71 participants were asked to rate the depth value of the garden using the magnitude estimation method in a cave automatic virtual environment (CAVE). Statistical analysis of Task 1 revealed that depth values differed significantly among different viewpoints. In Task 2, participants were asked to compare 18 stimuli and 3D images presented on three connected monitors and to judge the depth of the garden using the adjustment method. The results of Task 2 again showed that depth values differed significantly among different viewpoints. In both tasks, ambient information (i.e., the perspective of interior space) significantly influenced depth perception.
Sense of country: General and specific factors covary with social identification and predict emigration plans
Authors: Kolesovs Aleksandrs
Published: November 2022

Theoretical analyses of person–environment interaction describe complex models, addressing different levels of social systems, while models of the sense of community provide a base for transferring views of this interaction to the national level. This paper presents two studies that explored the structure of the sense of country and its relation to emigration plans and social identification. Study 1 involved 1,005 adults from Latvia. The Sense of Country Inventory (SOCI) included influence, perceived opportunities, belonging, and spatiotemporal commitment as the components of this sense. The bifactor model demonstrated the best fit and confirmed the general factor, integrating components of the sense of country, and specific factors, emphasizing its complexity. The validation demonstrated that the general sense of country is the main negative predictor of emigration plans. Study 2 included 247 participants who completed the SOCI and Identification With All Humanity Scale (IWAH). Correlating with national identification, the sense of country negatively predicted emigration plans that reflected the social identity continuity pathway. In turn, a negative relationship between the sense of country and global identification, which positively predicted emigration plans, revealed a social identity gain pathway. Together, the studies present the integrative nature of the sense of country and its links to emigration plans and national and global social identification.
Stress exposure status and associated factors among Chinese People's Armed Police personnel: A cross-sectional study
Authors: Li Nan , Zhang Yongzhong , Hou Shike
Published: November 2022

Background

MG (Mass gathering) deployment is one of the primary duties of Chinese People's Armed Police (PAP) personnel. Due to prolonged and repeated deployments in difficult conditions and harsh climates, military personnel are exposed to multiple stressors.

Objectives

This study aims to understand the stress exposure status of armed police personnel during MG deployment and to explore its influencing factors.

Methods

A cross-sectional study was conducted among PAP in 2021. We used a cluster random sampling to select 960 PAP personnel. Binary logistic regression was used to examine whether the stress exposure status was associated with factors such as demographics, health service utilization, and MG deployment.

Results

Among 960 PAP personnel,83% of PAP personnel participated in MG in the past month, and 23.1% of PAP personnel suffered stress. The chi-square test showed that there were significant differences in MG'cycle time (p < 0.05). The binary logistic regression results showed that satisfaction with medical skills (p = 0.008), satisfaction with health environment (p = 0.031), satisfaction with medicine (OR = 0.640, 95%CI:0.436,0.938), and seeking health services (OR = 5.36, 95%CI:2.316,12.402) were associated with stress exposure status. However, age, and length of military service did not have any association with the stress exposure status of PAP personnel in this study.

Conclusion

This study demonstrated that stress exposure status among PAP personnel was associated with MG deployment, and health service utilization. These findings can help policy-makers and clinicians to relieve the stress of the armed police personnel, as well as provide a basis for developing military health service security plans.
Identification of key long non-coding RNA-associated competing endogenous RNA axes in Brodmann Area 10 brain region of schizophrenia patients
Authors: Sabaie Hani , Gholipour Mahdi , Asadi Mohammad Reza , Abed Samin , Sharifi-Bonab Mirmohsen , Taheri Mohammad , Hussen Bashdar Mahmud , Brand Serge , Neishabouri Seyedeh Morvarid , Rezazadeh Maryam
Published: November 2022

Schizophrenia (SCZ) is a serious mental condition with an unknown cause. According to the reports, Brodmann Area 10 (BA10) is linked to the pathology and cortical dysfunction of SCZ, which demonstrates a number of replicated findings related to research on SCZ and the dysfunction in tasks requiring cognitive control in particular. Genetics' role in the pathophysiology of SCZ is still unclear. Therefore, it may be helpful to understand the effects of these changes on the onset and progression of SCZ to find novel mechanisms involved in the regulation of gene transcription. In order to determine the molecular regulatory mechanisms affecting the SCZ, the long non-coding RNA (lncRNA)-associated competing endogenous RNAs (ceRNAs) axes in the BA10 area were determined using a bioinformatics approach in the present work. A microarray dataset (GSE17612) consisted of brain post-mortem tissues of the BA10 area from SCZ patients and matched healthy subjects was downloaded from the Gene Expression Omnibus (GEO) database. This dataset included probes for both lncRNAs and mRNAs. Using the R software's limma package, the differentially expressed lncRNAs (DElncRNAs) and mRNAs (DEmRNAs) were found. The RNA interactions were also discovered using the DIANA-LncBase and miRTarBase databases. In the ceRNA network, positive correlations between DEmRNAs and DElncRNAs were evaluated using the Pearson correlation coefficient. Finally, lncRNA-associated ceRNA axes were built by using the co-expression and DElncRNA-miRNA-DEmRNA connections. We identified the DElncRNA-miRNA-DEmRNA axes, which included two key lncRNAs (PEG3-AS1, MIR570HG), seven key miRNAs (hsa-miR-124-3p, hsa-miR-17-5p, hsa-miR-181a-5p, hsa-miR-191-5p, hsa-miR-26a-5p, hsa-miR-29a-3p, hsa-miR-29b-3p), and eight key mRNAs (EGR1, ETV1, DUSP6, PLOD2, CD93, SERPINB9, ANGPTL4, TGFB2). Furthermore, DEmRNAs were found to be enriched in the “AGE-RAGE signaling pathway in diabetic complications”, “Amoebiasis”, “Transcriptional misregulation in cancer”, “Human T-cell leukemia virus 1 infection”, and “MAPK signaling pathway”. This study offers research targets for examining significant molecular pathways connected to the pathogenesis of SCZ, even though the function of these ceRNA axes still needs to be investigated.
Revision and psychometric properties of the negative cognitive processing bias scale
Authors: Miao Kuan , Liu Xuerong , Zhang Xiaoling , Li Yuanyuan , Liao Xingya , Zhang Rui , Feng Zhengzhi , Chen Zhiyi
Published: November 2022

Negative cognitive processing bias (NCPB) is a cognitive trait that makes individuals more inclined to prioritize negative external stimuli (cues) when processing information. Cognitive biases have long been observed in mood and anxiety disorders, improving validation of tools to measure this phenomenon will aid us to determine whether there is a robust relationship between NCPB and major depressive disorder, anxiety disorders and other clinical disorders. Despite the development of an initial measure of this trait, that is, the negative cognitive processing bias questionnaire (NCPBQ), the lack of psychometric examinations and applications in large-scale samples hinders the determination of its reliability and validity and further limits our understanding of how to measure the NCPB traits of individuals accurately. To address these issues, the current study evaluated the psychometric properties of the NCPBQ in a large-scale sample (n = 6,069), which was divided into two subsamples (Subsample 1, n = 3,035, serving as the exploratory subsample, and Subsample 2, n = 3,034, serving as the validation subsample), and further revised it into a standardized scale, that is the negative cognitive processing bias scale (NCPBS), based on psychometric constructs. The results show that NCPBS possesses good construct reliability, internally consistent reliability, and test-retest reliability. Furthermore, by removing two original items from NCPBQ, NCPBS was found to have good criterion-related validity. In conclusion, the present study provides a reliable and valid scale for assessing negative cognitive processing bias of individuals.
Investigating the molecular genetic, genomic, brain structural, and brain functional correlates of latent transdiagnostic dimensions of psychopathology across the lifespan: Protocol for a systematic review and meta-analysis of cross-sectional and longitudinal studies in the general population
Authors: Hoy Nicholas , Lynch Samantha , Waszczuk Monika , Reppermund Simone , Mewton Louise
Published: November 2022

Background

Research using latent variable modelling has identified a superordinate general dimension of psychopathology, as well as several specific/lower-order transdiagnostic dimensions (e.g., internalising and externalising) within the meta-structure of psychiatric symptoms. These models can facilitate discovery in genetic and neuroscientific research by providing empirically derived psychiatric phenotypes, offering greater validity and reliability than traditional diagnostic categories. The prospective review outlined in this protocol aims to integrate and assess evidence from research investigating the biological correlates of general psychopathology and specific/lower-order transdiagnostic symptom dimensions. Cross-sectional and longitudinal studies investigating general population samples of any age group or developmental period will be included to capture evidence from across the lifespan.

Methods and analysis

MEDLINE, Embase, and PsycINFO databases will be systematically searched for relevant literature. The review will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Eligibility criteria were designed to capture psychiatric genetic (i.e., molecular genetic and genomic) and neuroimaging (i.e., brain structural and brain functional) studies investigating latent transdiagnostic dimension(s) or structural model(s) of psychopathology across any age group. Studies which include or exclude participants based on clinical symptoms, disorders, or relevant risk factors (e.g., history of abuse, neglect, and trauma) will be excluded. Biometric genetic research (e.g., twin and family studies), candidate gene studies, neurophysiology studies, and other non-imaging based neuroscientific studies (e.g., post-mortem studies) will be excluded. Study quality and risk of bias will be assessed using the Joanna Briggs Checklist for Analytical Cross-Sectional Studies, the Joanna Briggs Checklist for Cohort Studies, and the Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) system. Meta-analysis will be conducted if sufficient data is available.

Discussion

This protocol outlines the first systematic review to examine evidence from studies investigating the latent structure and underlying biology of psychopathology and to characterise these relationships developmentally across the lifespan. The prospective review will cover a broad range of statistical techniques and models used to investigate latent transdiagnostic dimensions of psychopathology, as well as a numerous genetic and neuroscientific methods.

Systematic review registration

[https://www.crd.york.ac.uk/prospero/], identifier[CRD42021262717].
Financial technologies (FinTech) for mental health: The potential of objective financial data to better understand the relationships between financial behavior and mental health
Authors: Blair Johnna , Brozena Jeff , Matthews Mark , Richardson Thomas , Abdullah Saeed
Published: November 2022

Financial stability is a key challenge for individuals with mental illnesses. Symptomatic periods often manifest in poor financial decision-making including compulsive spending and risky behaviors. This article explores research opportunities and challenges in developing financial technologies (FinTech) to support individuals with mental health. Specifically, we focus on how objective financial data might lead to novel mental health assessment and intervention methods. We have used data from one individual with bipolar disorder (BD) (i.e., anN= 1 case study) to illustrate feasibility of collecting and analyzing objective financial data alongside mental health factors. While we have not found statistically significant trends nor our findings are generalizable beyond this case, our approach provides an insight into the potential of using objective financial data to identify early warning signs and thereby, enable preemptive care for individuals with serious mental illnesses. We have also identified challenges of accessing objective financial data. The paper outlines what data is currently available, what can be done with it, and what factors to consider when working with financial data. We have also explored future directions for developing interventions to support financial well-being and stability. Furthermore, we have described the technical, ethical, and equity challenges for financial data-driven assessments and intervention methods, as well as provided a broad research agenda to address these challenges.
Blood-derived deoxyribonucleic acid methylation clusters associate with adverse social exposures and endophenotypes of stress-related psychiatric illness in a trauma-exposed cohort of women
Authors: Pfeiffer John R. , van Rooij Sanne J. H. , Mekawi Yara , Fani Negar , Jovanovic Tanja , Michopoulos Vasiliki , Smith Alicia K. , Stevens Jennifer S. , Uddin Monica
Published: November 2022

Adverse social exposures (ASEs) such as low income, low educational attainment, and childhood/adult trauma exposure are associated with variability in brain region measurements of gray matter volume (GMV), surface area (SA), and cortical thickness (CT). These CNS morphometries are associated with stress-related psychiatric illnesses and represent endophenotypes of stress-related psychiatric illness development. Epigenetic mechanisms, such as 5-methyl-cytosine (5mC), may contribute to the biological embedding of the environment but are understudied and not well understood. How 5mC relates to CNS endophenotypes of psychiatric illness is also unclear. In 97 female, African American, trauma-exposed participants from the Grady Trauma Project, we examined the associations of childhood trauma burden (CTQ), adult trauma burden, low income, and low education with blood-derived 5mC clusters and variability in brain region measurements in the amygdala, hippocampus, and frontal cortex subregions. To elucidate whether peripheral 5mC indexes central nervous system (CNS) endophenotypes of psychiatric illness, we tested whether 73 brain/blood correlated 5mC clusters, defined by networks of correlated 5mC probes measured on Illumina’s HumanMethylation Epic Beadchip, mediated the relationship between ASEs and brain measurements. CTQ was negatively associated with rostral middle frontal gyrus (RMFG) SA (β =−0.231, p = 0.041). Low income and low education were also associated with SA or CT in a number of brain regions. Seven 5mC clusters were associated with CTQ (pmin = 0.002), two with low education (pmin = 0.010), and three with low income (pmin = 0.007). Two clusters fully mediated the relation between CTQ and RMFG SA, accounting for 47 and 35% of variability, respectively. These clusters were enriched for probes falling in DNA regulatory regions, as well as signal transduction and immune signaling gene ontology functions. Methylome-network analyses showed enrichment of macrophage migration (p = 9 × 10–8), T cell receptor complex (p = 6 × 10–6), and chemokine-mediated signaling (p = 7 × 10–4) pathway enrichment in association with CTQ. Our results support prior work highlighting brain region variability associated with ASEs, while informing a peripheral inflammation-based epigenetic mechanism of biological embedding of such exposures. These findings could also serve to potentiate increased investigation of understudied populations at elevated risk for stress-related psychiatric illness development.
Geographic accessibility to public and private health facilities in Kenya in 2021: An updated geocoded inventory and spatial analysis
Authors: Moturi Angela K. , Suiyanka Laurissa , Mumo Eda , Snow Robert W. , Okiro Emelda A. , Macharia Peter M.
Published: November 2022

Objectives

To achieve universal health coverage, adequate geographic access to quality healthcare services is vital and should be characterized periodically to support planning. However, in Kenya, previous assessments of geographic accessibility have relied on public health facility lists only, assembled several years ago. Here, for the first time we assemble a geocoded list of public and private health facilities in 2021 and make use of this updated list to interrogate geographical accessibility to all health providers.

Methods

Existing health provider lists in Kenya were accessed, merged, cleaned, harmonized, and assigned a unique geospatial location. The resultant master list was combined with road network, land use, topography, travel barriers and healthcare-seeking behavior within a geospatial framework to estimate travel time to the nearest (i) private, (ii) public, and (iii) both (public and private-PP) health facilities through a travel scenario involving walking, bicycling and motorized transport. The proportion of the population within 1 h and outside 2-h was computed at 300 × 300 spatial resolution and aggregated at subnational units used for decision-making. Areas with a high disease prevalence for common infections that were outside 1-h catchment (dual burden) were also identified to guide prioritization.

Results

The combined database contained 13,579 health facilities, both in the public (55.5%) and private-for-profit sector (44.5%) in 2021. The private health facilities' distribution was skewed toward the urban counties. Nationally, average travel time to the nearest health facility was 130, 254, and 128 min while the population within 1-h was 89.4, 80.5, and 89.6% for the public, private and PP health facility, respectively. The population outside 2-h were 6% for public and PP and 11% for the private sector. Mean travel time across counties was heterogeneous, while the population within 1-h ranged between 38 and 100% in both the public sector and PP. Counties in northwest and southeast Kenya had a dual burden.

Conclusion

Continuous updating and geocoding of health facilities will facilitate an improved understanding of healthcare gaps for planning. Heterogeneities in geographical access continue to persist, with some areas having a dual burden and should be prioritized toward reducing health inequities and attaining universal health coverage.
Correlates, motivating factors, and barriers of engaging in regular self-reflection among public health students in higher education—A mixed methods approach
Authors: Lim Raymond Boon Tar , Tan Claire Gek Ling , Hoe Kenneth Wee Beng , Teng Cecilia Woon Chien , Müller Andre Matthias , Azfar Julian , Narayanasamy Suganthi , Liow Chee Hsiang
Published: November 2022

Despite the wide implementation of self-reflection in higher education, the body of literature has predominantly focused on students from the clinical health sciences rather than public health. The objective of this study was to evaluate the correlates as well as to explore the motivating factors and barriers of engaging in regular self-reflection among public health students in higher education. We used a mixed methods approach (explanatory sequential design), comprising a cross-sectional survey (quantitative phase) followed by in-depth interviews (qualitative phase). We evaluated the association between reflection frequency as well as the perceptions and facilitators in reflection using the modified Breslow-Cox proportional hazards regression model. Prevalence ratio (PR) was generated. Thematic data analysis was carried out to analyse the qualitative data. Quantitative findings revealed being a regular reflector was positively associated with being more motivated to learn when one applied self-reflection (adjusted PR 1.60, 95% CI 1.17–2.20), the perception of being more prepared for a public health career in the future (adjusted PR 1.28, 95% CI 1.02–1.60), as well as being given enough opportunities to carry out self-reflection in the public health modules (adjusted PR 1.24, 95% CI 1.05–1.45). Qualitative findings revealed most students started their self-reflection mainly due to extrinsic factors such as institutional support, social support, teacher influence and environmental influence. Of these, the most prominent was teacher influence, indicating that they are key agents in promoting self-reflection. Students expressed that it would be important to cultivate intrinsic motivation to sustain their practice of self-reflection along the learning journey such as for the development of career-related professional skills. Other than intrinsic motivation, environmental influences were also important to promote continual reflection among students such as the availability of ample opportunities. Prominent barriers to address included external student factors such as the imbalanced power relationship between teacher and student, and internal student factors such as the perception that self-reflection was too cumbersome and time consuming.
Visual quality analysis using the Chinese Catquest-9SF scale following different spherical aberration IOL implantation
Authors: Wei Du , Wei Lou , Yanjun Hua , Zequan Xu , Lei Jin , Qiang Wu
Published: November 2022

Purpose

Based on the Chinese version of the Catquest-9SF scale, the contrast sensitivity meter and wavefront aberrometer were used to evaluate the visual quality of cataract patients implanted with different spherical aberrations IOL.

Design

Retrospective Observational Study.

Methods

Patients who had the lens implantation in our department from January 2020 to December 2021 were enrolled. All patients underwent uncorrected visual acuity, best corrected visual acuity and slit lamp microscope, high-order aberrations and contrast sensitivity test. The KR-1W wavefront analyzer (Topcon Medical System, Tokyo, Japan) was used to measure wavefront aberrations post-operation. The Chinese Catquest-9SF scale was used to score the postoperative visual satisfaction of the patients.

Results

145 patients were screened according to the exclusion criteria, including 51 patients in the zero aspherical IOL (SOFTEC HD) group, 42 patients in the negative aspherical IOL (ZCB00) group, and a total of 52 patients in the spherical IOL (HQ-201HEP) group. The score was the highest in the zero spherical aberration group, followed by the negative spherical aberration group with the lowest scores in the spherical IOL group. Higher-order aberrations are relatively low in eyes implanted with the zero spherical aberration group. Contrast sensitivity with spherical lenses under glare-free and glare conditions was lower than those with aspheric lenses, and at higher frequencies the zero-aberration aspheric lens performed the best.

Conclusion

The Chinese Catquest-9SF scale provides an indication of visual quality after aspheric IOL implantation.
Impact of COVID-19 on HIV services and anticipated benefits of vaccination in restoring HIV services in Ethiopia: A qualitative assessment
Authors: Amhare Abebe Feyissa , Zhao Min , Seeley Janet , Zhang Wei Hong , Goyomsa Girma Garedew , Geleta Tinsae Abeya , Zhao Rui , Zhang Lei
Published: November 2022

Background

HIV services were inevitably disrupted and affected due to COVID-19. There are many challenges in implementing appropriate HIV services, particularly in the provision of health care and the link between people living with HIV/AIDS and retention in care. The study investigated the impact of COVID-19 on HIV services and the anticipated benefit of the COVID-19 vaccination on HIV service restoration in North Shewa, Oromia, Ethiopia.

Methods

A qualitative descriptive study approach was used to explore how healthcare delivery evolved during the outbreak of COVID-19 in Ethiopia. Sixteen antiretroviral therapy (ART) clinics were selected from 13 districts and one administrative town in Ethiopia. From them, 32 ART providers were purposively selected based on their experience in ART provision. Data were collected from June to July 2021 using in-depth interviews. A thematic analysis approach was used to analyze the data, based on themes and subthemes emerging from the data. ATLAS.ti software was used for coding.

Results

Healthcare for people living with HIV was interrupted due to the COVID-19 pandemic. Medical appointments, HIV testing and counseling services, opportunistic infection treatment, medicine supply, and routine viral load and CD4 T-cell count tests were interrupted. Due to a shortage of healthcare staff, outreach testing services and home index testing were discontinued and HIV testing was limited only to hospitals and health centers. This has substantially affected accessibility to HIV testing and reduced the quality of HIV service delivery. Telehealth and less frequent visits to health facilities were used as alternative ways of delivering HIV services. The COVID-19 vaccination campaign is expected to restore healthcare services. Vaccination may also increase the confidence of healthcare providers by changing their attitudes toward COVID-19.

Conclusions

The COVID-19 pandemic has substantially impacted HIV services and reduced the quality of HIV care in Ethiopia. Health facilities could not provide routine HIV services as they prioritize the fight against COVID-19, leading to an increase in service discontinuation and poor adherence.
Trend of minimally processed and ultra-processed beverages purchased in Brazilian households: Less milk and much soft drink (2002–2003 to 2017–2018)
Authors: Oliveira Natália , Canella Daniela Silva
Published: November 2022

The consumption of ultra-processed beverages, including sugar-sweetened and artificially sweetened ones, is associated with several health problems, which is different considering minimally processed beverages. The objective of this study was to assess the trends in the volume of minimally and ultra-processed beverages purchased for consumption in Brazilian households and their relationship with the proportion of dietary energy derived from ultra-processed foods and beverages. Drawing on data from the nationwide 2002–03, 2008–09, and 2017–18 Household Budget Surveys, the daily volume of beverages purchased per capita (milligrams) was investigated. The minimally processed beverages purchased declined over the period [2002–2003: x̄ 156.5 ml (95%CI: 148.3–164.8); 2017–2018: x̄ 101.6 ml (95%CI: 98.1–105.1)] and ultra-processed beverages were stable [2002–03: x̄ 117.9 ml (95%CI: 108.1–127.7); 2017–18: x̄ 122.8 (95%CI: 111.2–134.4)]. The most purchased beverage in 2002–2003 was milk [x̄: 154.7 ml (95%CI: 146.4–162.9)], while in 2017–2018 regular soft drinks were the most purchased [x̄: 110.7 ml (95%CI: 99.2–122.2)]. There was a decrease in the purchase of whole and skimmed milk and an increase in the purchase of other ultra-processed beverages between the periods. With the increase in the proportion of ultra-processed foods and beverages in the diet, the volume of ultra-processed beverage purchases rose and minimally processed beverages declined. The monitoring of beverage consumption and the implementation of public policies, such as taxation on ultra-processed beverages, are essential to promote improvements in health and curbing non-communicable diseases.
Hand washing practice among public primary school children and associated factors in Harar town, eastern Ethiopia: An institution-based cross-sectional study
Authors: Berhanu Ashenafi , Mengistu Dechasa Adare , Temesgen Liku Muche , Mulat Salie , Dirirsa Gebisa , Alemu Fekade Ketema , Mangasha Adane Ermias , Gobena Tesfaye , Geremew Abraham
Published: November 2022

Background

Hand washing with soap and water reduces the risk of diarrheal episode by 28–48% and acute respiratory infection by 20–50%. However, there is limited evidence on hand washing practices among students in Eastern Ethiopia, particularly in Harari town. Therefore, this study aimed to determine hand washing practice among primary school students and associated factors in Harar town, Eastern Ethiopia.

Methods

An institution-based cross-sectional study was applied among 670 students in Harar town from June 1 to 30, 2021. A multi-stage sampling was employed; 6 out of 20 schools were selected through simple random sampling, while eligible children from each school was selected by probability proportional to size sampling method. Data were collected using a pre-tested questionnaire with a face-to-face interview technique and via observation. The data were analyzed using SPSS software version 23. Binary and mult-variable analysis were used to determine the association between factors and outcome variable. Finally, a p-value of < 0.05 was considered to declare a statistically significant association.

Results

A total of 670 participants were included in the study, of which 248 (37.0%) had washed their hands [95% CI: 33.3–40.06]. Being in grade 8 Adjusted Odd Ratio[AOR = 4.9; 95% Confidence Interval (CI): 2.28–10.52], living in an urban area [AOR = 3.49; 95% CI: 1.29–9.40], having role models (parents [AOR = 4.41; 95% CI: 1.79–10.86], teachers [AOR = 3.69; 95% CI: 1.39–8.81], and health professionals [AOR = 3.17, 95% CI: 1.17–8.63]), availability of hand washing facility [AOR = 3.62; 95% CI: 1.57–8.34], access to soap and water [AOR = 2.89; 95% CI: 1.39–5.98] and being membership of water sanitation and hygiene (WASH) club [AOR = 2.39; 95% CI: 1.41–4.03] were found to be significantly associated with hand washing practice.

Conclusions

The current study found that nearly a third of students practiced proper hand washing. Hand washing practice was influenced by students' grade level, residence, referents (role models for hand washing), presence of a hand washing facility, access to water and soap, and membership of WASH club. Therefore, the finding revealed that there is a need to improve hand-washing practices in schools by concerned agencies.
Geographic heterogeneity in Black-white infant mortality disparities
Authors: Côté-Gendreau Marielle , Donnelly Moran Katie
Published: November 2022

Despite recent decreases in Black infant mortality, racial disparities persist, motivating continued research into factors related to these inequalities. While the inverse association between education and infant mortality has been documented across races, less is known about its geographic heterogeneity. Using vital statistics from the National Center for Health Statistics, this study considers Black-white disparities in infant mortality for births occurring between 2011 and 2015 across regions and metropolitan status of maternal residence. With logistic regressions, we investigate heterogeneity in maternal educational gradients of infant mortality by geographic residence both within and between races. Beyond confirming the well-known relationship between education and infant mortality, our findings document a slight metropolitan advantage for infants born to white mothers as well as lower returns to education for infants born to Black mothers residing in nonmetropolitan counties. We observe a metropolitan advantage for infants born to Black mothers with at least a bachelor's degree, but a metropolitan disadvantage for infants born to Black mothers with less than a high school degree. The South is driving this divergence, pointing to particular mechanisms limiting returns to education for Southern Black mothers in nonmetropolitan areas. This paper's geographic perspective emphasizes that racial infant health disparities are not uniform across the country and cannot be fully understood through individual and household characteristics.
Factors associated with inadequate prenatal care service utilization in Ethiopia according to the WHO recommended standard guidelines
Authors: Woldeamanuel Berhanu Teshome
Published: November 2022

Background

Adequate maternal health care could prevent 54% of maternal deaths in low- and middle-income countries. In Ethiopia, the maternal mortality rate was reduced from 817 to 412 deaths per 100,000 live births between 2000 and 2016. Thus, the current study focuses on the adequacy of prenatal care (PNC) services rather than the mere prenatal contacts available to assess compliance with the WHO recommended standard guidelines.

Methods

A nationally representative cross-sectional dataset from the Ethiopian Mini Demographic and Health Survey 2019 was analyzed. Risk factors for prenatal care adequacy were assessed using a multilevel ordinal logistic regression model.

Results

About 43% of women met the old WHO recommendation of at least four prenatal contacts, while only 3.5% of women met the new WHO recommended minimum of eight prenatal contacts. The overall adequacy of prenatal care based on the four prenatal care utilization indicators was 52.1% no PNC, 37.4% received inadequate PNC and 10.5% received adequate PNC. Being a rural resident [AOR = 0.694 (95% CI: 0.557, 0.865)] and wanting no more children [AOR = 0.687 (95% CI: 0.544, 0.868)] are associated with inadequate prenatal care. Higher educational attainment of women and spouses, exposure to the media, upper wealth quintile, and a perceived shorter distance to a health facility were significantly associated with adequate prenatal care.

Conclusion

The prevalence of adequate prenatal care was lower. Multi-sectoral efforts are needed to improve maternal health targets by reducing maternal mortality through improved health care services.
Prohibitins in neurodegeneration and mitochondrial homeostasis
Authors: Fernandez-Abascal Jesus , Artal-Sanz Marta
Published: November 2022

The incidence of age-related neurodegenerative disorders has risen with the increase of life expectancy. Unfortunately, the diagnosis of such disorders is in most cases only possible when the neurodegeneration status is already advanced, and symptoms are evident. Although age-related neurodegeneration is a common phenomenon in living animals, the cellular and molecular mechanisms behind remain poorly understood. Pathways leading to neurodegeneration usually diverge from a common starting point, mitochondrial stress, which can serve as a potential target for early diagnosis and treatments. Interestingly, the evolutionarily conserved mitochondrial prohibitin (PHB) complex is a key regulator of ageing and metabolism that has been associated with neurodegenerative diseases. However, its role in neurodegeneration is still not well characterized. The PHB complex shows protective or toxic effects in different genetic and physiological contexts, while mitochondrial and cellular stress promote both up and downregulation of PHB expression. With this review we aim to shed light into the complex world of PHB’s function in neurodegeneration by putting together the latest advances in neurodegeneration and mitochondrial homeostasis associated with PHB. A better understanding of the role of PHB in neurodegeneration will add knowledge to neuron deterioration during ageing and help to identify early molecular markers of mitochondrial stress. This review will deepen our understanding of age-related neurodegeneration and provide questions to be addressed, relevant to human health and to improve the life quality of the elderly.
Recombinant factor VIII Fc fusion protein engages monocytes via Fc and FVIII domains to reduce monocyte differentiation into osteoclasts
Authors: Duan Susu , Dang Yifan , Rajani Gaurav Manohar , Kis-Toth Katalin , Salas Joe
Published: November 2022

Efmoroctocog alfa, a recombinant factor VIII Fc fusion protein referred to herein as rFVIIIFc, is an extended half-life factor replacement therapy approved for use in patients with hemophilia A. Previous studies have shown that rFVIIIFc has an immunoregulatory effect on monocyte-derived macrophages. This study provides novel findings and an understanding of how rFVIIIFc modulates monocyte differentiation into osteoclasts. rFVIIIFc was found to engage with Fc-gamma receptors (FcγR) on the monocyte surface, leading to increased inhibitory FcγR signaling in cells. Monocyte differentiation into osteoclastsin vitrowas inhibited in a concentration-dependent manner following rFVIIIFc treatment, with the interaction between the Fc domain of rFVIIIFc and FcγRII on monocytes playing a role in this effect. The C1 and C2 domains of rFVIIIFc were also found to play a role in inhibiting osteoclast formation. rFVIIIFc treatment of monocytes skewed their differentiation from osteoclasts into a group of less differentiated monocytes with unique myeloid cell phenotypes. The results of this study suggest that rFVIIIFc has a unique immune-regulatory effect on monocyte differentiation, inhibiting osteoclast formation. We propose a “double touchpoint” model for rFVIIIFc interaction with monocytes, with both the Fc domain and domains of FVIII binding to the monocyte surface. Further study is needed to determine if this immune-regulatory effect has any potential benefit on the bone and joint health of patients with hemophilia A receiving rFVIIIFc.
Do the Expert Recommendations for Implementing Change (ERIC) strategies adequately address sustainment?
Authors: Nathan Nicole , Powell Byron J. , Shelton Rachel C. , Laur Celia V. , Wolfenden Luke , Hailemariam Maji , Yoong Sze Lin , Sutherland Rachel , Kingsland Melanie , Waltz Thomas J. , Hall Alix
Published: November 2022

Background

Sustainability science is an emerging area within implementation science. There is limited evidence regarding strategies to best support the continued delivery and sustained impact of evidence-based interventions (EBIs). To build such evidence, clear definitions, and ways to operationalize strategies specific and/or relevant to sustainment are required. Taxonomies and compilations such as the Expert Recommendations for Implementing Change (ERIC) were developed to describe and organize implementation strategies. This study aimed to adapt, refine, and extend the ERIC compilation to incorporate an explicit focus on sustainment. We also sought to classify the specific phase(s) of implementation when the ERIC strategies could be considered and applied.

Methods

We used a two-phase iterative approach to adapt the ERIC. This involved: (1) adapting through consensus (ERIC strategies were mapped against barriers to sustainment as identified via the literature to identify if existing implementation strategies were sufficient to address sustainment, needed wording changes, or if new strategies were required) and; (2) preliminary application of this sustainment-explicit ERIC glossary (strategies described in published sustainment interventions were coded against the glossary to identify if any further amendments were needed). All team members independently reviewed changes and provided feedback for subsequent iterations until consensus was reached. Following this, and utilizing the same consensus process, the Exploration, Preparation, Implementation and Sustainment (EPIS) Framework was applied to identify when each strategy may be best employed across phases.

Results

Surface level changes were made to the definitions of 41 of the 73 ERIC strategies to explicitly address sustainment. Four additional strategies received deeper changes in their definitions. One new strategy was identified: Communicate with stakeholders the continued impact of the evidence-based practice. Application of the EPIS identified that at least three-quarters of strategies should be considered during preparation and implementation phases as they are likely to impact sustainment.

Conclusion

A sustainment-explicit ERIC glossary is provided to help researchers and practitioners develop, test, or apply strategies to improve the sustainment of EBIs in real-world settings. Whilst most ERIC strategies only needed minor changes, their impact on sustainment needs to be tested empirically which may require significant refinement or additions in the future.
How Does Lifestyle Affect Colorectal Cancer Risk?
Authors: Malcomson Fiona C. , Willis Naomi D. , Mathers John C.
Published: November 2022

Lifestyle—what we eat, how much exercise we do, and how much we weigh, can change our chances of getting diseases like cancer in the large intestine (colorectal cancer). The World Cancer Research Fund has come up with eight lifestyle recommendations to lower our chances of getting cancer. For example, we are recommended to eat at least five servings of fruits and vegetables every day. It is also important that we understand how our lifestyles, and following these recommendations, affects our chances of getting cancer. How does a healthier diet, doing more exercise, and maintaining a healthy weight affect the biological processes that lead to cancer? In our study, we wanted to find out how sticking to these Cancer Prevention Recommendations could keep us protected from cancers in the large intestine.
Efficient Spatiotemporal Graph Search for Local Trajectory Planning on Oval Race Tracks
Authors: Rowold Matthias , Ögretmen Levent , Kerbl Tobias , Lohmann Boris
Published: November 2022

Autonomous racing has increasingly become a research subject as it provides insights into dynamic, high-speed situations. One crucial aspect of handling these situations, especially in the presence of dynamic obstacles, is the generation of a collision-free trajectory that represents a safe behavior and is also competitive in the case of racing. We propose a local planning approach that generates such trajectories for a racing car on an oval race track by searching a spatiotemporal graph. A considerable challenge of search-based methods in a spatiotemporal domain is the curse of dimensionality. Therefore, we propose how a previously presented graph structure that is based on intervals instead of discrete values can be searched more efficiently without losing optimality by using a uniform-cost search strategy. We extend the search method to make it anytime-capable so that it can provide a suboptimal trajectory even if the search has to be terminated early. The graph-based planning approach allows us to apply a flexible cost function so that our approach can operate fully autonomously on an oval race track, including the pit lane. We present a cost function for oval racing and explain how the terms contribute to the desired behaviors. This is supported by results with a full-scale prototype.
Design and Experimental Study of a Turbojet VTOL Aircraft with One-Dimensional Thrust Vectoring Nozzles
Authors: Liu Benshan , Gao Yongsheng , Gao Liang , Zhang Junming , Zhu Yanhe , Zang Xizhe , Zhao Jie
Published: November 2022

Turbojet engines have a slow response and require mechanical assistance to perform vertical take-offs and landings. In this paper, we propose a vertical take-off and landing (VTOL) aircraft that contains one-dimensional thrust vectoring nozzle modules to solve the problem of dependence on the response of the turbojet. The turbojet engine is placed horizontally in the module, the rotational speeds are fixed, and the force along the turbojet axis remains constant as the nozzle rotates from the horizontal to the vertical position. The aircraft is composed of four modules, whose position and attitude control are realized by using the thrust difference caused by the different angles of the four vector nozzles. The modules no longer rely on the response speed of the turbojet engine, and controlling the angles of four nozzles makes it easier to operate the aircraft. The horizontal placement of the turbojet can reduce the thickness of the aircraft fuselage and decrease air resistance. The process of moving the nozzle from a horizontal to a vertical position prevents the engine from blowing directly on the ground and, thus, reduces the ground effect.