bluuebunny/crossref_metadata_2025 huggingface dataset:
Metalloprotease inhibitor profiles of human ADAM8 in vitro and in cell-based assays
Authors: Schlomann Uwe , Dorzweiler Kristina , Nuti Elisa , Tuccinardi Tiziano , Rossello Armando , Bartsch Jörg W.
Published: February 2019

ADAM8 as a membrane-anchored metalloproteinase-disintegrin is upregulated under pathological conditions such as inflammation and cancer. As active sheddase, ADAM8 can cleave several membrane proteins, among them the low-affinity receptor FcεRII CD23. Hydroxamate-based inhibitors are routinely used to define relevant proteinases involved in ectodomain shedding of membrane proteins. However, for ADAM proteinases, common hydroxamates have variable profiles in their inhibition properties, commonly known for ADAM proteinases 9, 10 and 17. Here, we determined the inhibitor profile of human ADAM8 for eight ADAM/MMP inhibitors by in vitro assays using recombinant ADAM8 as well as the in vivo inhibition in cell-based assays using HEK293 cells to monitor the release of soluble CD23 by ADAM8. ADAM8 activity is inhibited by BB94 (Batimastat), GW280264, FC387 and FC143 (two ADAM17 inhibitors), made weaker by GM6001, TAPI2 and BB2516 (Marimastat), while no inhibition was observed for GI254023, an ADAM10 specific inhibitor. Modeling of inhibitor FC143 bound to the catalytic sites of ADAM8 and ADAM17 reveals similar geometries in the pharmacophoric regions of both proteinases, which is different in ADAM10 due to replacement in the S1 position of T300 (ADAM8) and T347 (ADAM17) by V327 (ADAM10). We conclude that ADAM8 inhibitors require maximum selectivity over ADAM17 to achieve specific ADAM8 inhibition.
LncRNA HOTAIR targets miR-126-5p to promote the progression of Parkinson’s disease through RAB3IP
Authors: Lin Qiuyu , Hou Sen , Dai Yuyin , Jiang Nan , Lin Yingjie
Published: February 2019

Parkinson’s disease (PD) is a common neurological disorder characterized by dopaminergic (DA) neuron degeneration and death in the midbrain, and the long noncoding RNA HOTAIR has been shown to affect disease progression in PD. In this study, we aimed to further illustrate the molecular mechanism of HOTAIR in PD. Bioinformatics analysis was utilized to determine the potential downstream targets of HOTAIR in PD. Luciferase assay and the RNA Binding Protein Immunoprecipitation (RIP) assay were used to validate the existence of binding sites between competing endogenous RNAs (ceRNAs). Real-time quantitative polymerase chain reaction (qRT-PCR) and Western blotting indicated that HOTAIR and RAB3IP increased while miR-126-5p decreased in PD cells and PD mice. Additionally, the CCK-8 assay and flow cytometric analysis indicated that the knockdown of HOTAIR and RAB3IP and the overexpression of miR-126-5p significantly increased cell proliferation and reduced apoptosis in PD cells. Furthermore, the results of in vivo experiments suggested that knockdown of HOTAIR expression increased the number of TH-positive cells and the number of α-synuclein-positive cells decreased while reducing the apoptosis rate among DA neurons. Our study confirmed that HOTAIR promotes PD progression by regulating miR-126-5p and RAB3IP in a ceRNA-dependent manner and further clarified how HOTAIR works in PD.
Deconstructing the Opacity of Pari Passu Clause as a Pathway to Interpretative Clarity: Guidepost to Optimal Adjudicatory Outcomes
Authors: Ajibo Collins C.
Published: February 2019

The opacity that underlines the substantive content and interpretation of pari passu clause in financial contracting requires more clarity to ensure predictability for the contracting parties relying on it to access fund in the financial markets. The re-awakening of the contextual and textual controversy that underpins the clause by the NML case has once again re-enacted the divergent positions, namely: the broad or payment interpretation and narrow or equal ranking obligation. Consequently, there is a need for more clarity on the substantive content of the pari passu clause so that contracting parties will not be prejudiced in the event of dispute. Effectively, parties can achieve this by clarifying ex ante the applicable meaning of the clause. The contracting parties may state in the financial contractual agreement that the applicable meaning of the clause is a broad or payment interpretation. Alternatively, the contracting parties may adopt narrow interpretation; or entirely exclude the application of the pari passu clause. Also, parties may need to incorporate collective action clause (CAC) to ensure that the collective decisions of the majority of lenders prevail over undue proclivity for holdouts of the minority. This will dispel the possibility of controversy ex post over rateable payment, while ensuring orderly debt restructuring.
Persistence Conditions and Identity
Authors: Biro John
Published: February 2019

Pluralists believe that there are cases of distinct but spatio-temporally coinciding things. The statue goes, the piece of clay remains: differing persistence conditions, different things. Yet while both are with us, they are obviously in the same place. The argument rests on two assumptions: that statues have their shape essentially and that pieces of clay do not. Only if we make both does the conclusion follow. Here I suggest that while both assumptions are plausible on their face, each may be questioned. Given this, we are not forced to accept their conjunction and can thus avoid the counter-intuitive conclusion it entails.
Performance of microaerobic granular sludge system for pentachlorophenol (PCP) degradation responding to PCP loading shock
Authors: Lan Hui-xia , Zhang Hao , Yang Da , Qi Shixin , Zhang Heng , Liang Chen
Published: February 2019

The microaerobic granular sludge for pentachlorophenol (PCP) degradation was obtained in our laboratory which had excellent effect and physical-chemical properties at PCP loading of 3.0×10−2 kg·m−3·d−1. In this paper, the effects of PCP loading shock on the operation of microaerobic granular sludge system, dechlorination intermediate product, fermentation climax community and flocculation performance of sludge were studied with the PCP loading of 5.0×10−2 kg·m−3·d−1 and 8.0×10−2 kg·m−3·d−1. The results showed that the activity of microaerobic granular sludge decreased due to the shock of PCP loading, leading to the reduction of COD and PCP removal efficiency, the accumulation of dechlorination intermediate and short chain fatty acids, and the decrease of sludge flocculation performance. Acidogenic fermentation climax community changed from acetic acid type to acid fermentation and the activity of microaerobic granular sludge could be recovered just for 2 days under the PCP loading of 5.0×10−2 kg·m−3·d−1, whereas the climax community converted to mixed fermentation of propionic acid and butyric acid and the activity of microaerobic granular sludge struggled to recover the previous level after 8 days under the PCP loading of 8.0×10−2 kg·m−3·d−1.
Structural Changes of Farm Size and Labor’s Occupation in Bangladesh- A Markov Chain Analysis
Authors: Salam Shakila , Bauer Siegfried
Published: February 2019

Over the last few decades, Bangladesh has experienced significant structural changes within the agricultural sector. This research estimates the current and forecasts the future changes of farm size and labor occupational mobility over time and across the region. A panel dataset, which is used in this study, was collected in the three different years (1988, 2000 and 2008) from 62 villages across 57 districts. Stationary Markov chain approach was used in this analysis to estimate structural change. The results of this study imply that the agricultural sector is dominated by small farms in past, present and also in the future. The forecasting predicts that the numbers of marginal, medium and large farms are going to decrease in future. Moreover, it indicates that the average farm size of small landholders will slightly increase as the numbers of marginal and large landowners reduces. The analyses of the transition probabilities of labor occupational change show that rural households are gradually shifting to non-farm activities and mostly part-time farming from other income generating activities over time. In general, the forecast also suggests narrowing of agricultural activities and expansion of part-time farming and non-farm activities in future.
How to influence the trajectory of organic agriculture’s development when you are not in the driver’s seat? The case of the French National Federation of Organic Farming
Authors: Chance Quentin , Le Velly Ronan , Goulet Frédéric
Published: February 2019

This article describes the actions taken by the National Federation of Organic Farming (FNAB) to try to influence the course of organic agriculture's development in France. This federation wields the strength that accrues from its network of regional associations, but has no direct control over the economic actions of farmers and enterprises in the organic sector. It is trying to influence these actions in three different ways. First, it is drawing up a normative framework, a stabilised discourse about the risks that are linked to the current strong growth of the market and about the economic model and values that it wants to defend in this context. Second, the FNAB tries to affect the ways that the food supply chains are organised by promoting certain production and trade organisation schemes. Third, the FNAB produces information and references to help farmers and economic operators get their market bearings.
Assessing the linkage between dairy productivity growth and climatic variability: The case of New York State
Authors: Ranjan Alok , Mukherjee Deep
Published: February 2019

Despite the importance of maintaining a high productivity level for the future viability of the dairy sector in the face of changing climate, very few studies have investigated how climatic conditions impact total factor productivity (TFP) growth in dairy farming. In order to bridge this gap in literature, we conducted a TFP decomposition exercise using dairy farm summary records from the New York state which is one of the historically major milk producing regions of the United States. Stochastic frontier models with air temperature, incorporated as an environmental input in an otherwise conventional dairy production function, are estimated using an unbalanced panel of constructed ‘average’ dairy farms of various size-classes covering a sufficiently long time-period. Change in TFP is then decomposed into various components namely technological change, technical efficiency change, and scale efficiency change. Further analysis also establishes that the introduction of average air temperature in the stochastic production frontier soaks what otherwise could be attributed to inefficiency and/or model residual.
Perceptions of Turkish Entrepreneurs and Employees About Hungarian Business Environment and Attitudes
Authors: Onalan Mehmet Sercan , Magda Robert
Published: February 2019

Since the enrolment of Turkey in the Customs Union, Turkish exporters start to explore the Hungarian market and day by day increased the volume of trade between those two nations. In this case, the location of Hungary had a significant role, not just for the internal market but also potential to have trade with neighbour countries. Today, partially, the opportunities in Hungary are starting to become noticed by Turkish entrepreneurs. In the last decade, the main characteristic of the Turkish in Hungary is that they went to this country as entrepreneurs. The main characteristic that distinguishes the Turks living in Hungary from other European countries is that they are entrepreneurs, not workers. The aim of this research is to reveal the differences between the perceptions of Turkish entrepreneurs and employees of Hungarian business environment and attitudes towards Turkish entrepreneurship. This study was carried out on a total of 102 participants who were divided into two equal groups in terms of the number of participants. In results, it has been found out that employees and entrepreneurs has been differed by educational level, duration time in Hungary and sector which they operate. In short, the motivation of employees to be an entrepreneur is low.
Prenatal Microcephaly and Hydrocephalus and Normal Heart Anatomy, Postnatal Diagnosis of Nijmegen Syndrome - Case Report
Authors: Wójtowicz-Marzec Monika , Respondek-Liberska Maria
Published: February 2019

Nijmengen breakage syndrome is a rare autosomal condition mainly characterized by microcephaly. Patients are predisposed to malignancies due to combined immunodeficiency. The presented patient had prenatally diagnosed microcephaly with atypical ventriculomegaly of occipital horns. Fetal echocardiography showed a normal fetal heart anatomy. Diagnosis of Nijmengen syndrome was confirmed postnatally. The differential diagnosis of fetal microcephaly should take into account intrauterine infections, perinatal brain injury, congenital malformations or biological variants.
Remember they were emotional - Effects of emotional qualifiers during sentence processing
Authors: Child Scarlett , Garnham Alan , Oakhill Jane
Published: February 2019

We investigated whether emotional information facilitates retrieval and whether it makes representations more salient during sentence processing. Participants were presented with sentences including entities (nouns) that were either bare, with no additional information or that were emotionally or neutrally qualified by means of adjectives. Reading times in different word regions, specifically at the region following the verb where retrieval processes are measurable, were analysed. Qualified representations needed longer time to be build up than bare representations. Also, it was found that the amount of information and the type of information affect sentences processing and more specifically retrieval. In particular, retrieval for emotionally specified representations was faster than that for bare representations.
Occurrence and significance of folic acid
Authors: Cieślik Ewa , Cieślik Iwona
Published: February 2019

Folic acid is a naturally occurring pteridine, which was originally isolated from plants. Folic acid (pteroyl-glutamic acid) is composed of pteridine (6-methylptero), p-aminobenzoic acid (PABA) and glutamic acid. Folic acid (folacin) is a compound of major importance for the proper functioning of the human body. Its adequate supply is essential for the proper course of many biochemical processes in the body, including the process of neural tube closure in the fetus, DNA and amino acid synthesis, growth of red blood cells, and the function of the nervous system. Folic acid is a compound of a high sensitivity to physical and chemical factors, and its bioavailability is limited by interactions with multiple food components. Therefore, folate deficiency is one of the most common deficiencies. This paper presents the structure and characteristics of folic acid as a pteridine, it also discusses dietary sources of folate and the effects of its deficiency.
Could the inhibitor of DNA binding 2 and 4 play a role in white matter injury?
Authors: Gou Xiaoyun , Tang Ying , Qu Yi , Xiao Dongqiong , Ying Junjie , Mu Dezhi
Published: February 2019

White matter injury (WMI) prevents the normal development of myelination, leading to central nervous system myelination disorders and the production of chronic sequelae associated with WMI, such as chronic dyskinesia, cognitive impairment and cerebral palsy. This results in a large emotional and socioeconomic burden. Decreased myelination in preterm infant WMI is associated with the delayed development or destruction of oligodendrocyte (OL) lineage cells, particularly oligodendrocyte precursor cells (OPCs). The development of cells from the OL lineage involves the migration, proliferation and different stages of OL differentiation, finally leading to myelination. A series of complex intrinsic, extrinsic and epigenetic factors regulate the OPC cell cycle withdrawal, OL lineage progression and myelination. We focus on the inhibitor of DNA binding 2 (ID2), because it is widely involved in the different stages of OL differentiation and genesis. ID2 is a key transcription factor for the normal development of OL lineage cells, and the pathogenesis of WMI is closely linked with OL developmental disorders. ID4, another family member of the IDs protein, also plays a similar role in OL differentiation and genesis. ID2 and ID4 belong to the helix-loop-helix family; they lack the DNA-binding sequences and inhibit oligodendrogenesis and OPC differentiation. In this review, we mainly discuss the roles of ID2 in OL development, especially during OPC differentiation, and summarize the ID2-mediated intracellular and extracellular signaling pathways that regulate these processes. We also discuss ID4 in relation to bone morphogenetic protein signaling and oligodendrogenesis. It is likely that these developmental mechanisms are also involved in the myelin repair or remyelination in human neurological diseases.
Investigation of Influence of Drill Geometry and Thrust Force During Drilling of Aluminium 2014 Alloy on Burr Formation Through Design of Experiments and Nueral Network
Authors: Sreenivasulu Reddy , Rao Chalamalasetti Srinivasa
Published: February 2019

Drilling is a hole making process on machine components at the time of assembly work, which were identify everywhere. In precise applications quality and accuracy play wide role. Now a day’s industries are suffered by cost incurred during deburring, especially in precise assemblies such as aerospace/aircraft body structures, marine works and automobile industries. Burrs produced during drilling causes dimensional errors, jamming of parts and misalignment. Therefore, deburring operation after drilling is often required. Now, reducing burr size is a burning topic. In this study experiments are conducted by choosing various input parameters selected from previous researchers. Effect of alteration of drill geometry on thrust force and burr size of drilled hole investigated as per taguchi design of experiments and found optimum combination of most significant input parameters from ANOVA to get optimum reduction in burr size by design expert software. Drill thrust influences more on burr size, clearance angle of drill bit causes variation in thrust, burr height observed in this study. Compare these output results with neural network software @easy NN plus. Finally, concluded that increasing the number of nodes increases the computational cost and decreases the error in nueral network. Good agreement was shown between the predictive model results and the experimental responses.
Integration of Management Systems, Synergy of Quality, Knowledge and Risks in Business Management
Authors: Litvaj Ivan , Makarovič Juraj , Bůžek Miloslav
Published: February 2019

This article focuses on modern management systems. It describes the systems in the defined space dealing with the possibility of their integration into one management system. Therefore, the focus is specifically on quality management, risk management, knowledge management. The quality management means customer orientation and fulfillment of requirements, the risk management means risk-based thinking and knowledge management in the business (knowledge management).
On Magnetohydrodynamic Unsteady Flows with Induced Field Over A Stretching Surface
Authors: Ferdows M. , Bangalee M.Z.I , Liu Don
Published: February 2019

The problem of unsteady, incompressible, laminar electrically conducting flow part a continuously stretching surface is investigated based on a time depended length scale. Similarity conditions for the stretching surface flow velocity and induced magnetic field functions are denied. The governing partial differential equations are first transformed to ordinary ones using similarity transformation. The governing system of equation includes the continuity equation, magnetic continuity equation, Maxwell’s equation, momentum equation and magnetic equations. The resulting similarity equation is then obtained through the use of Maple software. Effects of the unsteadiness parameter A, magnetic force parameter β and the reciprocal of the magnetic prandtl number ë on the velocity and magnetic induction functions are displayed graphically.
Review on The Performance of Softened Two-Bit Hard Combination Scheme for Cooperative Spectrum Sensing
Authors: Abdulhamid Mohanad
Published: February 2019

This paper measures the performance of cooperative spectrum sensing, over Rayleigh fading channel and additive white Gaussian noise, based on softened two-bit hard combination scheme. Two measures based on energy detection are considered including effect of false alarm probability, and effect of number of users. Simulation results show that the detection probability increases with the increase of false alarm probability, number of users, and signal-to-noise-ratio.
Kinetics and Kinematics of the Squat and Step-up in Well-Trained Rugby Players
Authors: Appleby Brendyn B. , Newton Robert U. , Cormack Stuart J.
Published: February 2019

Appleby, BB, Newton, RU, and Cormack, SJ. Kinetics and kinematics of the squat and step-up in well-trained rugby players. J Strength Cond Res 33(7S): S36–S44, 2019—The purpose of this study was to compare and contrast the kinetics and kinematics of squat and step-up performance in well-trained athletes. Triaxial ground reaction force (GRF) and 3D kinematic data were collected in 4 maximal effort repetitions each at 70, 80, and 90% of 1 repetition maximum (1RM) of squat and step-up. The difference in concentric phase kinetics and kinematics between the squat and step-up was compared using effect sizes (ES ± 90% confidence limits [CLs]) classified as: less than 0.2 as trivial; 0.2–0.6 as small; 0.6–1.2 as moderate; and 1.2–2.0 as large. Where the 90% CL crossed negative and positive 0.2 values, the effect was considered “unclear.n Ground reaction force was higher for the step-up than squat at all relative intensities per leg (peak GRF ES: 2.56 ± 0.19 to 2.70 ± 0.37; average GRF ES: 1.45 ± 0.27 to 1.48 ± 0.29). Per leg, the difference in concentric impulse favored the step-up compared with squat at 70% 1RM (ES = 0.71 ± 0.40) and 80% 1RM (ES = 0.30 ± 0.41) but was unclear at 90% 1RM (ES = −0.25 ± 0.47). The squat peak velocity was greater compared with step-up at all intensities (ES = −1.74 ± 0.48 to −1.33 ± 0.48). Despite a lower external load and a single base of support, per leg, the step-up produced comparable GRF because the squat suggesting overload provided by the step-up is sufficient for maximal strength development. Future research may investigate the efficacy of the step-up in a training intervention for the development of lower-body strength.
Jumping Asymmetries Are Associated With Speed, Change of Direction Speed, and Jump Performance in Elite Academy Soccer Players
Authors: Bishop Chris , Brashill Calum , Abbott Will , Read Paul , Lake Jason , Turner Anthony
Published: February 2019

Bishop, C, Brashill, C, Abbott, W, Read, P, Lake, J, and Turner, A. Jumping asymmetries are associated with speed, change of direction speed, and jump performance in elite academy soccer players. J Strength Cond Res 35(7): 1841–1847, 2021—The aim of this study was to establish interlimb asymmetries across different age groups in elite academy male soccer players and to examine any relationships between asymmetry and measures of physical performance. Fifty-one players from an English Premier League soccer academy were split into under-23 (n = 21), under-18 (n = 14), and under-16 (n = 16) groups and performed bilateral and unilateral countermovement jumps, 5-, 10-, and 20-m sprints, and a 505 change of direction speed tests. All tests showed low variability (coefficient of variation ≤ 2.5%) and good to excellent reliability (intraclass correlation coefficient = 0.80–0.99). A 1-way analysis of variance showed that the under-23 group was significantly faster than the under-16 group during the 20-m sprint (2.90 vs. 2.98 s; p = 0.02; effect size = 0.94). No other significant differences were present between groups. Interlimb asymmetry was quantified from the single-leg countermovement jump, and no significant differences in the magnitude of asymmetry were present between groups. However, multiple significant correlations were present in each age group between asymmetry and physical performance tests, all of which were indicative of reduced athletic performance. Results from this study show that although interlimb asymmetry scores are comparable across age groups in elite academy soccer players, differences as low as 5% are associated with reduced physical performance during jumping, sprinting, and change of direction speed tasks. This study suggests the importance of monitoring jump height asymmetries in elite academy soccer players.
Acute Effect of a Single Session of Pilates on Blood Pressure and Cardiac Autonomic Control in Middle-Aged Adults With Hypertension
Authors: Rocha Jeferson , Cunha Felipe A. , Cordeiro Ricardo , Monteiro Walace , Pescatello Linda S. , Farinatti Paulo
Published: February 2019

Rocha, J, Cunha, FA, Cordeiro, R, Monteiro, W, Pescatello, LS, and Farinatti, P. Acute effect of a single session of Pilates on blood pressure and cardiac autonomic control in middle-aged adults with hypertension. J Strength Cond Res 34(1): 114–123, 2020—We investigated the blood pressure (BP) and heart rate variability (HRV) responses to a single session of Pilates among adults with hypertension. Thirteen participants (7 women), aged 44–66 years, underwent Pilates and nonexercise control sessions separated by 48–72 hours in a randomized counterbalanced order. Blood pressure and HRV indices were simultaneously assessed 10 minutes before and 60 minutes after all sessions in the supine position: root mean square of successive differences (rMSSD), percentage of successive normal sinus RR intervals >50 ms (pNN50), SD of all normal sinus RR intervals over 24 hours (SDNN), and low-frequency (LF) and high-frequency (HF) bands. After an acute session of Pilates, the mean values for area under the curve for systolic BP (p = 0.004, corresponding to −7.4 ± 8.2 mm Hg) and mean arterial pressure (p = 0.023, corresponding to −5.3 ± 5.4 mm Hg) were significantly lower compared to the control session. No significant difference was detected for diastolic BP (−4.2 ± 4.7 mm Hg, p = 0.106). Concomitant to BP reduction, significant lowering of parasympathetic HRV indices occurred: RR intervals (−64.1 ± 69.9 ms·min−1, p = 0.043), rMSSD (−8.3 ± 15.4 ms·min−1, p = 0.013), pNN50 (−3.6 ± 13%·min−1, p = 0.028), and total power (−3,089.4 ± 5,938 m2·min−1, p = 0.037). No difference was found for sympathetic markers: SDNN (−17.7 ± 34.6 ms·min−1, p = 0.100), LF (−5.2 ± 21,6 n.u.·min−1, p = 0.417), and LF:HF ratio (−0.3 ± 5.2 ratio·min−1, p = 0.422). In conclusion, a single session of Pilates reduced BP by ∼5–8 mm Hg in adults with hypertension during the first 60 minutes of post-exercise recovery. Acute BP reduction was concomitant to lowered cardiac parasympathetic activity. Our findings are promising for the use of Pilates as an alternative exercise modality to lower BP.
Assessment of a Novel Algorithm to Determine Change-of-Direction Angles While Running Using Inertial Sensors
Authors: Balloch Aaron S. , Meghji Mahir , Newton Robert U. , Hart Nicolas H. , Weber Jason A. , Ahmad Iftekhar , Habibi Daryoush
Published: February 2019

Balloch, AS, Meghji, M, Newton, RU, Hart, NH, Weber, JA, Ahmad, I, and Habibi, D. Assessment of a novel algorithm to determine change-of-direction angles while running using inertial sensors. J Strength Cond Res 34(1): 134–144, 2020—The ability to detect and quantify change-of-direction (COD) movement may offer a unique approach to load-monitoring practice. Validity and reliability of a novel algorithm to calculate COD angles for predetermined COD movements ranging from 45 to 180° in left and right directions was assessed. Five recreationally active men (age: 29.0 ± 0.5 years; height: 181.0 ± 5.6 cm; and body mass: 79.4 ± 5.3 kg) ran 5 consecutive predetermined COD trials each, at 4 different angles (45, 90, 135, and 180°), in each direction. Participants were fitted with a commercially available microtechnology unit where inertial sensor data were extracted and processed using a novel algorithm designed to calculate precise COD angles for direct comparison with a high-speed video (remotely piloted, position-locked aircraft) criterion measure. Validity was assessed using Bland-Altman 95% limits of agreement and mean bias. Reliability was assessed using typical error (expressed as a coefficient of variation [CV]). Concurrent validity was present for most angles. Left: (45° = 43.8 ± 2.0°; 90° = 88.1 ± 2.0°; 135° = 136.3 ± 2.1°; and 180° = 181.8 ± 2.5°) and Right: (45° = 46.3 ± 1.6°; 90° = 91.9 ± 2.2°; 135° = 133.4 ± 2.0°; 180° = 179.2 ± 5.9°). All angles displayed excellent reliability (CV < 5%) while greater mean bias (3.6 ± 5.1°, p < 0.001), weaker limits of agreement, and reduced precision were evident for 180° trials when compared with all other angles. High-level accuracy and reliability when detecting COD angles further advocates the use of inertial sensors to quantify sports-specific movement patterns.
Analysis of Genetic Diversity and Population Structure in Three Forest Musk Deer Captive Populations with Different Origins
Authors: Fan Jiamin , Zheng Xueli , Wang Hongyong , Qi Hong , Jiang Benmo , Qiao Meiping , Zhou Jianwen , Bu Shuhai
Published: February 2019

Musk deer (Moschidae), whose secretion is an expensive and irreplaceable component of traditional medicine, have become endangered in the wild due to habitat fragmentation and over-exploitation. In recent years, China has had success in the artificial breeding of forest musk deer, thus relieving the pressure on wild populations. However, many farmed populations are experiencing degradation, and little genetic information is available for conservation management. In this study, we selected 274 individuals from three typical captive populations (originated from the Ta-pa Mountains (Tp), the midrange of the Qinling Mountains (Ql) and the Western Sichuan Plateau (WS), respectively) to evaluate the genetic variations. A total of more than 3.15 billion high-quality clean reads and 4.37 million high-quality SNPs were generated by RAD sequencing. Based on the analysis, we found that captive forest musk deer populations exhibit a relatively low level of genetic diversity. Ql displayed a higher level of genetic diversity than the Tp and WS populations. Tp and WS had experienced population bottlenecks in the past as inferred from the values of Tajima’s D. There were high levels of heterozygote deficiency caused by inbreeding within the three populations. Population structure analysis suggested that the three populations have evolved independently, and a moderate amount of genetic differentiation has developed, although there was a low level of gene flow between the Ql and Tp populations. Furthermore, the average quantities of musk secreted by musk deer in the Tp and WS populations were significantly higher than that in the Ql population. The present genetic information should be considered in management plans for the conservation and utilization of musk deer from captive breeding.
NILAI EKONOMI EKOSISTEM TERUMBU KARANG DI TAMAN WISATA PERAIRAN KAPOPOSANG, SULAWESI SELATAN
Authors: Muliawan Irwan , Firdaus Maulana
Published: February 2019

ABSTRAK Penilaian terhadap ekosistem pada kawasan konservasi menjadi sangat penting sebagai dasar pertimbangan bagi pengelolaan kawasan konservasi perairan. Kajian ini bertujuan untuk menghitung nilai ekonomi ekosistem terumbu karang di Taman Wisata Perairan (TWP) Kapoposang, Provinsi Sulawesi Selatan. Data primer dikumpulkan melalui wawancara terhadap pemanfaat sumber daya; sedangkan data sekunder berupa jumlah populasi pemanfaat (nelayan) di sekitar kawasan, jumlah wisatawan dan luas kawasan dikumpulkan melalui penelusuran literatur dan laporan-laporan yang tersedia.  Analisis data dilakukan menggunakan teknik valuasi ekonomi sumber daya, yaitu teknik Effect on Production dan Zonal Travel Cost Method.  Hasil kajian menunjukkan bahwa nilai manfaat ekonomi ekosistem terumbu karang di TWP Kapoposang adalah sebesar Rp1.698.945.542,-/ha/tahun; sedangkan nilai ekonomi wisata di TWP Kapoposang adalah sebesar Rp467.753.989,-/ha/tahun. Nilai ekonomi manfaat wisata terlihat kontradiksi jika dibandingkan dengan total nilai kesediaan membayar (U) yang dibayarkan oleh pengunjung sebesar Rp2.012,-/pengunjung/tahun, yang mengindikasikan penghargaan pengunjung terhadap sumber daya terumbu karang relatif rendah. Pengembangan pariwisata pada kawasan konservasi khususnya di TWP Kapoposang sangat penting dilakukan agar memberikan dampak atau manfaat ekonomi yang tinggi, sehingga pemanfaatan yang bersifat ekstraksi sumber daya  pada kawasan konservasi dapat berkurang. Title: Economic Value Of Coral Reef Ecosystem In The Kapoposang Marine Park Conservation, South SulawesiABSTRACT Assessment of economic value of ecosystems in the conservation areas is very important as a basis for consideration of management marine conservation areas. This study aims to estimate the economic value of coral reef ecosystems in Kapoposang Aquatic Tourism Park, South Sulawesi Province. Primary data was collected through interviews with resource users and secondary data in the form of number of users (fishers) around the area, size of the area itself and number of tourists were collected through literature studies and compiled the available report. Data were analysedusing economic valuation techniques, namely Effect on Production and Zonal Travel Cost Method techniques. Results of the study show that the value of the economic benefits of the coral reef ecosystem in the Kapoposang TWP was IDR 1,698,945,542/ha/year whereas for the tourism in Kapoposang TWP was IDR 467,753,989/ha/year. This values were contradicted with the current amount of money paid by tourist visitors of IDR 2.012/visitor/year of which considered their willingness to pay (U) to the resource. The development of tourism in conservation areas, especially in the Kapoposang TWP, is very important to be carried out in order to provide high economic impact or benefits so that the extraction resources utilization in the conservation areas can be reduced.
PENOLAKAN ITHBAT NIKAH SIRI BAGI ‎SUAMI YANG SUDAH BERISTRI ‎
Authors: Roqib Muhammad
Published: February 2019

Abstract: This study reviews the judge’s legal consideration basis in rejecting the confirmation of unregistered marriage (isbat nikah) for a husband who had married in the Religion Court’s decision of Nganjuk No: 1339/Pdt.G/2013/PA.Ngj and how the analysis of Islamic law against the denial of the confirmation of unregistered marriage for a husband who had married in the Religious Court’s decision of Nganjuk. The data of the research are obtained through documentation and interview. The data are then analyzed by descriptive-deductive mindset. This study concludes that the consideration and the legal basis used by the judge in the case of the confirmation of unregistered marriage is Article 4, paragraph 1 of Law No. 1 of 1974 About Marriage jo. Article 52 paragraph 1 Islamic Law Compilation. In Article 5, paragraph 1 (a) of Law No. 1 of 1974 jo. Article 58, paragraph 1 (a) Islamic Law Compilation states that one of the requirements of conducting polygamy is the condition must be approved by wife. The judge rejected the request of the confirmation of unregistered marriage because in this case, according to the judge, is classified as polygamy. Judge just looks at the judicial aspect without considering the principles of maqasid al-shari’ah. In this case, the very important to note is the civil right and welfare of children which is one of the main constituents of hifzd al-nasl (protection of children) that should be maintained. In consideration of hifzd al-nasl, the petition of the confirmation of unregistered marriage should have been granted.Abstrak: Penelitian ini mengkaji tentang dasar pertimbangan hukum hakim dalam menolak ithbat nikah siri bagi suami yang sudah beristri dalam putusan Pengadilan Agama Nganjuk nomor: 1339/Pdt.G/2013/ PA.Ngj dan bagaimana analisis hukum Islam terhadap penolakan ithbat nikah siri bagi suami yang sudah beristri dalam putusan Pengadilan Agama Nganjuk tersebut. Data penelitian ini diperoleh melalui dokumentasi dan wawancara yang selanjutnya dianalisis dengan metode deskriptif menggunakan pola pikir deduktif. Penelitian ini berkesimpulan bahwa, pertimbangan dan dasar hukum yang digunakan hakim dalam menetapkan perkara ithbat nikah adalah pasal 4 ayat 1 Undang-Undang No 1 Tahun 1974 Tentang Perkawinan jo. Pasal 52 ayat 1 Kompilasi Hukum Islam. Dalam pasal 5 ayat 1 (a) Undang-Undang No 1 Tahun 1974 jo. Pasal 58 ayat 1 (a) Kompilasi Hukum Islam bahwa salah satu syarat berpoligami harus ada persetujuan dari istri. Hakim menolak permohonan ithbat nikah karena pada kasus ini menurut majelis hakim tergolong perkara poligami. Hakim hanya melihat dari aspek yuridis tanpa mempertimbangkan maqasid al-shari’ah.  Dalam kasus ini yang sangat penting untuk diperhatikan adalah  hak-hak keperdataan dan kesejahteraan anak yang merupakan salah satu unsur pokok hifzu al-nasli yang harus terpelihara. Dengan pertimbangan tersebut permohonan ithbat nikah ini seharusnya dikabulkan.Kata Kunci: ithbat nikah dan nikah sirri
FENOMENA POLIGAMI ANTARA SOLUSI SOSIAL DAN WISATA SEKSUAL DALAM ANALISIS HUKUM ISLAM, UU NO. 1 TAHUN 1974, DAN KHI
Authors: Rohman Moh. Faizur , Solikhudin Muhammad
Published: February 2019

Abstract: Polygamy is one of the problem in the marriage of the most discussed widely and controversial. One side of polygamy is rejected with a variety of arguments between normative, psychological, even always associated with gender injustice-as revealed by gender activists or activists of women. In fact, Western writers often claim that polygamy is evidence that the teaching of Islam in the areas of marriage is very discriminatory against women. On the other side, polygamy campaigned as it is considered as one alternative to resolve the phenomenon of cheating and prostitution. Whatever the reasons said, clearly polygamy is a religion shari'ah presence clearly in the Qur'an, regardless of how this verse applied. The issue is under what conditions and by whom this polygamy shari'ah can be implemented. This paper attempts to examines polygamy on one side of the impact on social solution, on the other side can be regarded as sexual tourism which is conducted the husband, and could also both reasons join simultaneously. Furthermore, the authors discuss polygamy with analysis knife of Islamic Law, Law No. 1 of 1974, and KHI (Positive Law). Not only that, the authors also attempt to align polygamy study it with a knife of  analysis the theory of phenomenology in sociology.

Keywords: polygamy, Islamic Law, Positive Law, Phenomenology.
DINAMIKA DALIL HUKUM HAKIM DALAM PENETAPAN PERMOHONAN DISPENSASI NIKAH DI PENGADILAN AGAMA NGANJUK TAHUN 2015
Authors: Siswanto Dwi
Published: February 2019

Penelitian yang berjudul “Dinamika Dalil Hukum Hakim dalam Penetapan Permohonan Dispensasi Nikah di Pengadilan Agama Nganjuk Tahun 2015” merupakan hasil penelitian hukum normative yang bertujuan menjawab pertanyaan tentang dalil hukum hakim, perbedaan penggunaan dalil hukum Hakim dan tinjauan hukum Islam terhadap penetapan permohonan dispensasi nikah di Pengadilan Agama Nganuk Tahun 2015.

Penelitian ini menggunakan metode penelitian hukum doctrinal, dengan data primer berasal dari salinan penetapan permohonan dispensasi nikah di  Pengadilan Agama Nganjuk Tahun 2015, selain salinan penetapan penelitian ini juga menggunakan data sekunder yang berasal dari buku – buku hukum dengan tujuan menunjang penjelasan data primer, dengan menggunakan analisis induktif kemudian ditarik pada yang umum. Mengenai dalil hukum hakim.

Proses penelitian yang dilakukan menemukan bahwa  pertimbangan hukum hakim tidak hanya berpedoman pada ketentuan yang berlaku, melainkan majelis hakim menggunakan pendekatan metodologi pengkajian hukum Islam maslahah mursalah, terhadap wanita hamil di luar nikah. mengenai terjadinya perbedaan penggunaan dalil hukum hakim hanya sebagai dasar hukum hakim dalam penetapannya dikarenakan pada permohonan tersebut menggunakan penasehat hukum dan ketentuan mengenai permohonan yang digugurkan dan dicabut. Dalil hukum hakim sudah sesuai dengan Islam.

Kesimpulan yang diperoleh dalam penelitian hukum normative yang menggunakan penelitian metode penelitian doctrinal, menyatakan bahwa pertimbangan hukum hakim tidak hanya berpedoman pada ketentuan yang berlaku, melainkan majelis hakim, menggunakan pendekatan metodologi pengkajian hukum Islam maslahah mursalah. dan pertimbangan terhadap perlindungan dan kepastian hukum terhadap keberadaan anak, terhadap wanita hamil diluar nikah, mengenai terjadinya perbedaan penggunaan dalil hukum hakim hanya sebagai dasar hukum penetapan dikarenakan pada permohonan tersebut menggunakan penasehat hukum dan ketentuan mengenai permohonan yang digugurkan dan dicabut, dalil hukum hakim sudah sesuai dengan Islam, maka permohonan Pemohon patut diterima.

Saran dalam penelitian ini ditujakan kepada 2 (dua) pihak , pertama orang tua, agar lebih mempertimbangkan lagi untuk menikahkan anaknya karena pernikahan dibawah ketentuan sangat bahaya misalnya hamil diusia muda, kedua hakim di lingkungan Peradilan Agama agar hendaknya berhati – hati dalam memberikan izin dispensasi nikah agar tidak dijadikan celah bagi masyarakat dengan mudah mendapatkan izin dispensasi nikah.

Keywords: Dalil Hukum dan Dispensasi Nikah
Analisis maslahah al-mursalah terhadap akad nikah via teleconference
Authors: Yasrony Mohammad Aniq
Published: February 2019

Abstract: penelitian yang berjudul “Analisis Maslahah al-Mursalah Terhadap Akad Nikah via Teleconference”  ini merupakan hasil penelitian pustaka untuk menjawab pertanyaan: Bagaimana pelaksanaan akad nikah dengan menggunakan teleconference?, Bagaimana analisis Maslahah al-Mursalah terhadap fenomena akad nikah via teleconference?.

Data penelitian dihimpun dengan menggunakan pendekatan kualitatif melalui pengumpulan data dengan teknik studi dokumen. Selanjutnya data yang telah dihimpun diatur dan disesuaikan dengan akar permasalahannya kemudian dianalisis menggunakan teori Maslahah al-Mursalah. Adapun metodenya adalah deskriptif analisis dan menggunakan pola pikir deduktif yakni memaparkan teori  Maslahah al-Mursalah sebagai teori ushul fiqh  untuk menganalisis problematika akad nikah via teleconference secara lebih mendalam.

Berdasarkan penelitian ini diperoleh hasil bahwa pelaksanaan akad nikah via teleconference awal mulanya dilaksanakan di Negara Timur Tengah yaitu Negara Mesir. Pernikahan dengan model akad nikah antara calon mempelai laki-laki dan calon mempelai perempuan tidak berada dalam satu tempat, dianggap tidak sah karena proses akad nikah tersebut tidak dilaksanakan dalam satu majelis.

Hasil penelitian menyimpulkan bahwa proses akad nikah menggunakan teknologi teleconference ini didasarkan atas keinginan dari pihak pengantin atau karena kondisi yang tidak memungkinkan untuk bertemu secara langsung. Proses akad nikah yang dilakukan tidak melalui pertemuan langsung. Praktik yang terjadi ialah ketika calon mempelai laki-laki dengan calon mempelai perempuan tidak duduk bersama-sama dalam satu majelis, namun komunikasi atau ijab kabul di antara mereka tetap terjalin dengan menggunakan video conference. Penggunaan yang lebih modern lagi bisa melalui aplikasi skype sehingga komunikasi tercipta layaknya pertemuan secara langsung.

Hasil analisis menggunakan teori ushul fiqh Maslahah al-Mursalah memberikan jawaban bahwa akad nikah via teleconference dihukumi boleh dan sah manakala dilakukan sesuai aturan hukum Islam, dan terpenuhi semua rukun-rukunnya. Pelaksanaan akad nikah model ini tidak bertentangan dengan rumusan ilmu fiqh yang menjadi cikal bakal terbentuknya hukum Islam.

Akad nikah yang menjadi sunnah Rasulullah Saw seharusnya tidak dipahami secara statis dalam pelaksanaannya. Sejalan dengan perkembangan waktu, era modernisasi dan globalisasi menuntut adanya pengembangan dalam ilmu pengetahuan dan teknologi. Pada hakikatnya suatu hukum harus merelevansikan dengan kebutuhan dan situasi zaman. Sehingga semua lapisan masyarakat menjadi paham akan pentingnya ilmu pengetahuan, teknologi disandingkan dengan ilmu fiqh.

Keywords: maslahah mursalah dan teleconference
Tradisi Pernikahan Dengan Kesetaraan Keturunan Dalam Keluarga Para Mas Sidosermo Kecamatan Wonocolo Surabaya Dan Berbek Kecamatan Waru Sidoarjo
Authors: Hidayatulloh Rohmat
Published: February 2019

Abstract: Dalam penulisan artikel ini penulis mengambil judul “TINJAUAN HUKUM ISLAM TERHADAP TRADISI PERNIKAHAN DENGAN KESETARAAN KETURUNAN (Studi Kasus Pernikahan di Keluarga Para Mas Sidosermo Kecamatan Wonocolo Surabaya dan Berbek Kecamatan Waru Sidoarjo)”. Penelitian ini bertujuan untuk mengetahui 1) Bagaimana pernikahan kesetaraan keturunan di keluarga para Mas Sidosermo Kecamatan Wonocolo Surabaya dan Berbek Kecamatan Waru Sidoarjo. 2) Bagaimana tinjauan hukum Islam terhadap pernikahan dengan kesetaraan keturunan dikeluarga para Mas Sidosermo Kecamatan Wonocolo Surabaya dan Berbek Kecamatan Waru Sidoarjo.

Jenis penelitian ini menggunakan jenis penelitian Field Research. Teknik pengumpulan data diambil menggunakan teknik observasi, wawancara dan dokumentasi. Selanjutnya data yang telah dihimpun, dianalisis menggunakan metode deskriptif kualitatif Pola pikir yang dipakai dalam penelitian ini adalah dengan menggunakan pola pikir deduktif.

Berdasarkan hasil wawancara yang diperoleh, dapat dinyatakan bahwa sebagian besar keluarga Mas di kelurahan Sidosermo Kecamatan Wonocolo Surabaya sangat mempertimbangkan kekufuan calon suami dan calon istri dalam hal nasab dan agama. Menjadikan nasab dan agama sebagai kriteria kafaah bagi keluarga para Mas merupakan hal yang sangat pokok yang harus dipenuhi. Sebagian besar keluarga Mas di Kelurahan Sidosermo masih menganggap nasab dan agama sebagai ukuran kafaah yang paling pokok dalam perkawinan. Hal ini disebabkan karena mereka merupakan keturunan Rasulullah saw. Berbeda dengan di Berbek, tradisi pernikahan para Mas di Berbek saat ini tidak memperhitungkan nasab dari calon suami atau istri. Yang paling terpenting adalah ada kecocokan diantaranya, ilmu agama dan akhlaknya. Pada generasi saat ini  kriteria kafaah di Berbek adalah agama. Keluarga Mas di Berbek hanya mengutamakan kualitas agamanya karena orang yang mempunyai agama yang bagus, otomatis dia sholeh, dan berakhlak mulia dan tidak ada kekhususan dalam segi nasab karena itu merupakan prinsip zaman dahulu yang telah berubah di zaman sekarang.

Sejalan dengan kesimpulan diatas, disarankan pada zaman modern ini banyak dilakukan pemahaman yang mampu mempengaruhi prinsip kafaah masyarakat khususnya para Mas terlebih pada pergaulan anak muda di zaman sekarang yang bebas memilih. Oleh karenanya konsep kafaah tersebut harus di ajarkan kepada anak keturunannya supaya mereka mengerti dan faham serta mampu melaksanakan kafaah yang telah di ajarkan oleh orang tua mereka sehingga menjadi keluarga yang saki@nah mawaddah waroh{mah.

Keywords: Hukum Islam, Kafaah.
Pengasuhan Anak Menurut Hukum Islam
Authors: Junaidy Abdul Basith
Published: February 2019

Perceraian yang terjadi antara suami isteri mengakibatkan konsekwensi terhadap pihak ketiga, yaitu anak-anak. Kewajiban orang tua terhadap anak tidak terbatas pada saat perkawinan masih utuh, akan tetapi kewajiban itu terus berlangsung meski perkawinan mereka telah putus. Persoalan yang muncul adalah mengenai siapa di antara kedua orang tua itu yang paling layak untuk melakukan pengasuhan. Secara prinsip, Islam memberikan ketentuan bahwa ibu lebih layak untuk mengasuh karena alasan biasanya ibu lebih memiliki kasih sayang dibanding ayah. Namun, Islam, sebagai ajaran yang memiliki misi Rahmatan lil Alamin, menetapkan prinsip universal dalam hal ini, yaitu syarat utama pengasuh anak adalah memiliki sikap amanah dan memiliki kecakapan. Syarat amanah meliputi  sikap moral yang baik dan tidak merusak agama anak. Pengasuh non muslim diperkenankan asalkan tidak dikhawatirkan merusak agama anak. Syarat kecakapan menuntut  kesediaan pengasuh untuk meluangkan waktu untuk anak.  Atas dasar itu, posisi ibu, misalnya,  sebagai pengasuh bisa saja digantikan ayah jika ia tidak amanah. Dan penentuan amanah atau tidaknya seorang pengasuh ditetapkan oleh Pengadilan Agama.