bluuebunny/crossref_metadata_2025 huggingface dataset:
A DNA tetrahedron-based molecular computation device for the logic sensing of dual microRNAs in living cells
Authors: Lin Qing , Wang Anmin , Liu Shiyuan , Li Jing , Wang Jiaoli , Quan Ke , Yang Xiaohai , Huang Jin , Wang Kemin
Published: March 2020

Endogenous miRNA expression patterns are specific to cell type and thus offer high prediction accuracy with regard to different cell identities compared to single miRNA analysis.
Synthesis of functionalized tetrahydropyrans via cascade cycloaddition involving silyloxyallyl cation intermediates
Authors: Badmus Fatimat O. , Malone Joshua A. , Fronczek Frank R. , Kartika Rendy
Published: March 2020

An expedient synthesis of highly substituted tetrahydrobenzofuran via an unsymmetrical silyloxyallyl cation is reported.
Highly porous aluminophosphates with unique three dimensional open framework structures from mild hydrothermal syntheses
Authors: Hao Yucheng , Pan Yang , Lin Yuan , He Linbo , Ge Guangjie , Ruan Yu , Zhou Haida , Xue Yang , Koirala Kisan
Published: March 2020

Three novel highly porous aluminophosphates were synthesized through mild hydrothermal methods. Interestingly, among them, α-NaAlPO4(OH) is polar and exhibits moderate nonlinear optical properties with a short cutoff edge.
Time-resolved formation of excited atomic and molecular states in XUV-induced nanoplasmas in ammonia clusters
Authors: Michiels Rupert , LaForge Aaron C. , Bohlen Matthias , Callegari Carlo , Clark Andrew , von Conta Aaron , Coreno Marcello , Di Fraia Michele , Drabbels Marcel , Finetti Paola , Huppert Martin , Oliver Veronica , Plekan Oksana , Prince Kevin C. , Stranges Stefano , Svoboda Vít , Wörner Hans Jakob , Stienkemeier Frank
Published: March 2020

The formation of excited hydrogen in XUV-induced ammonia plasmas was studied in a time-resolved way using an XUV-UV pump–probe scheme.
Photochemistry of HNSO2 in cryogenic matrices: spectroscopic identification of the intermediates and mechanism
Authors: Chen Changyun , Wang Lina , Zhao Xiaofang , Wu Zhuang , Bernhardt Bastian , Eckhardt André K. , Schreiner Peter R. , Zeng Xiaoqing
Published: March 2020

Photolysis of the matrix-isolated N-sulfonylamine HNSO2 yields fragments HONO, HO˙, ˙NO, ˙NO2, and S2 and also novel isomers HONSO, HOSNO, HOS(O)N, HS(O)NO, HN(O)SO, HSONO, and a caged radical pair HOS˙⋯˙NO.
Simulations of valence excited states in coordination complexes reached through hard X-ray scattering
Authors: Källman Erik , Guo Meiyuan , Delcey Mickaël G. , Meyer Drew A. , Gaffney Kelly J. , Lindh Roland , Lundberg Marcus
Published: March 2020

Theoretical guide to the valence electronic structure information that can be extracted from hard X-ray scattering experiments.
Domino lignin depolymerization and reconnection to complex molecules mediated by boryl radicals
Authors: Hong Longcheng , Spielmeyer Astrid , Pfeiffer Janin , Wegner Hermann A.
Published: March 2020

Lignin has been demonstrated as a source of complex molecules via a boryl-mediated domino degradation/reconnection process.
Dehydra-decyclization of 2-methyltetrahydrofuran to pentadienes on boron-containing zeolites
Authors: Kumar Gaurav , Liu Dongxia , Xu Dandan , Ren Limin , Tsapatsis Michael , Dauenhauer Paul J.
Published: March 2020

1,3-Pentadiene (piperylene) is an important monomer in the manufacturing of adhesives, plastics, and resins. This study utilizes fundamental insights gained from the dehydra-decyclization of biomass-derived 2-methyltetrahydrofuran to achieve high piperylene yields.
Facile preparation of porous palladium nanocubes via a one-pot process induced by 1-hexadecyl-3-methyl imidazolium bromide for methanol electro-oxidation
Authors: Cui Zelin , Bai Xuefeng , Liu Teng
Published: March 2020

Pd porous nanocubes were synthesized by a one-pot method assisted by HMIB and exhibited higher activity than solid nanocubes and Pd/C.
Organically templated zinc selenite compounds: synthesis, structural chemistry and DFT calculations
Authors: Lunardi Andressa , Nunes Cechin Camila , Lang Ernesto Schulz , Cargnelutti Roberta , Ramirez Pineda Nahum , Piquini Paulo Cesar , Burrow Robert Alan , Santos dos Santos Sailer , Bortolotto Tanize , Tirloni Bárbara
Published: March 2020

The first examples of organically templated zinc selenite compounds containing closed-frameworks have been synthesized via solvothermal processes and characterized by spectroscopy, crystallographic methods and DFT calculations.
1,3,4-Oxadiazole based thermostable energetic materials: synthesis and structure–property relationship
Authors: Yan Tingou , Cheng Guangbin , Yang Hongwei
Published: March 2020

A combination of 1,3,4-oxadiazole and pyrazole produces a series of new compounds with satisfactory energetic properties.
A natural cyanobacterial protein C-phycoerythrin as an Hg2+ selective fluorescent probe in aqueous systems
Authors: Ghosh Tonmoy , Chatterjee Sobhan , Bhayani Khushbu , Mishra Sandhya
Published: March 2020

C-phycoerythrin (CPE) as a natural protein-based fluorescence ‘turn off’ probe for Hg2+ in aqueous systems.
The role of dipole moment in two fused-ring electron acceptor and one polymer donor based ternary organic solar cells
Authors: Liao Xunfan , Cui Yongjie , Shi Xueliang , Yao Zhaoyang , Zhao Heng , An Yongkang , Zhu Peipei , Guo Yaxiao , Fei Xiang , Zuo Lijian , Gao Ke , Lin Francis , Xie Qian , Chen Lie , Ma Wei , Chen Yiwang , Jen Alex K.-Y.
Published: March 2020

The dipole moment of FREAs’ terminals has been unveiled as an important factor and its working mechanism has been thoroughly investigated. Our results demonstrate that the dipole moment should also be taken into account in designing ternary OSCs.
Proving the robustness of a PEDOT:PSS-based thermistorviafunctionalized graphene oxide–poly(vinylidene fluoride) composite encapsulation for food logistics
Authors: Maskey Bijendra Bishow , Shrestha Kiran , Sun Junfeng , Park Hyejin , Park Jinhwa , Parajuli Sajjan , Shrestha Sagar , Jung Younsu , Ramasundaram Subramaniyan , Koirala Gyan Raj , Cho Gyoujin
Published: March 2020

We introduced a FGO–PVDF composite as an encapsulation layer to prove the reliability of PEDOT:PSS thermistors under high-humidity conditions to realize an NFC-enabled smart label for monitoring time-temperature history of a food item along the cold chain.
Bifunctional phase-transfer catalysts for synthesis of 2-oxazolidinones from isocyanates and epoxides
Authors: Cui Dong-Xiao , Li Yue-Dan , Huang Ping , Tian Zhuang , Jia Yan-Yan , Wang Ping-An
Published: March 2020

A series of bifunctional phase-transfer catalysts were synthesized to catalyze the [3 + 2] coupling reaction of isocyanates and epoxides to afford 2-oxazolidinones in good to high yields (up to 92% yield) using PhCl as a solvent at 100 °C within 12 h.
Ultra-fine platinum species supported on niobium pentoxide for CO oxidation
Authors: Wang Miao-Miao , Yu Jing , Wang Dao-Lei , Si Rui
Published: March 2020

Ultrafine-clustered metallic Pt species are considered to be more active than oxidized Pt single ions for CO oxidation reaction.
Structural transition and magnetic properties of Mn doped Bi0.88Sm0.12FeO3 ceramics
Authors: Hien N. T. , Vinh N. D. , Dang N. V. , Trang T. T. , Van H. T. , Thao T. T. , Hue L. T. , Tho P. T.
Published: March 2020

We investigated the effects of Mn doping on the crystal structure, phonon vibration, and magnetic properties of Bi0.88Sm0.12FeO3 ceramics.
Bipolar-interface fuel cells – an underestimated membrane electrode assembly concept for PGM-free ORR catalysts
Authors: Seeberger Dominik , McLaughlin David , Hauenstein Pascal , Thiele Simon
Published: March 2020

We present the first combination of a bipolar interface fuel cell with a commercial Fe–N/C catalyst as an alkaline cathode and a PGM-based, acidic anode, both separated by a proton exchange membrane (PEM).
Surface buckling delamination patterns of film on soft spherical substrates
Authors: Emori Kanako , Saito Yusaku , Yonezu Akio , Zhu Liangliang , Liao Xiangbiao , Chen Xi
Published: March 2020

The morphological transition of film buckling-delamination in an elastomeric bilayer spherical shell system was studied experimentally and numerically. It was changed by the film thickness, Young's modulus, and interfacial adhesion condition, etc.
An intrinsically stretchable and ultrasensitive nanofiber-based resistive pressure sensor for wearable electronics
Authors: Liang Fang-Cheng , Ku Hau-Jen , Cho Chia-Jung , Chen Wei-Cheng , Lee Wen-Ya , Chen Wen-Chang , Rwei Syang-Peng , Borsali Redouane , Kuo Chi-Ching
Published: March 2020

Nanofiber-based electronics with unique fibrous interlocked microstructures are capable of differentiating various mechanical stimuli, such as normal pressure, lateral strain, and bending. Skin-inspired electronics with an ultrahigh sensitivity of 71.07 kPa−1 under a small applied pressure (<0.06 kPa), a rapid response time (<2 ms), and highly reproducible stability (>5000 cycles) are reported, thereby demonstrating their potential applications in versatile human–machine interfaces.
A novel efficient single-phase dual-emission phosphor with high resemblance to the photosynthetic spectrum of chlorophyll A and B
Authors: Fang Shuangqiang , Lang Tianchun , Han Tao , Cai Mingsheng , Cao Shixiu , Peng Lingling , Liu Bitao , Zhong Yang , Yakovlev Alexey N. , Korepanov Vladimir I.
Published: March 2020

Light is a fuel for photosynthesis and plays an irreplaceable role in seed germination, stem elongation, leaf expansion, flowering induction, and accumulation of nutrients.
Urban cold-chain logistics demand predicting model based on improved neural network model
Authors: Chen Ying , Wu Qiuming , Shao Lijin
Published: March 2020

With the popularity of the Internet and mobile terminals, the development of e-commerce has become hotter. Therefore, e-commerce research starts to focus on the statistics and prediction of the cargo volume of logistics. This study briefly introduced the back-propagation (BP) neural network model and principal component analysis (PCA) method and combined them to obtain an improved PCA-BP neural network model. Then the traditional BP neural network model and the improved PCA-BP neural network model were used to perform the empirical analysis of the cold chain logistics demand of fruits and vegetables in city A from 2010 to 2018. The results showed that the main factors that affected the local cold chain logistics demand were the growth rate of GDP, the added value of primary industry, the planting area of fruits and vegetables, and the consumption price index of fruits and vegetables; both kinds of neural networks model could effectively predict the cold chain logistics demand, but the predicted value of the PCA-BP neural network model was more fitted with the actual value. The prediction error of the BP neural network model was larger, and the fluctuation was obvious within the prediction interval. Moreover, the time required for the prediction by the PCA-BP neural network model was less than that by the BP neural network model. In summary, the improved PCA-BP neural network model is faster and more accurate than the traditional BP model in predicting the cold chain logistics demand.
How suitable are man-made water bodies as habitats for Odonata?
Authors: Vilenica Marina , Pozojević Ivana , Vučković Natalija , Mihaljević Zlatko
Published: March 2020

Many studies have reported a negative impact of freshwater habitat modification on biota. Nevertheless, some man-made water bodies have proven to be valuable for biodiversity conservation as they can harbour many species. We investigated 36 man-made water bodies to determine their suitability as habitats for Odonata. Larvae were sampled in littoral, during the summer months of 2016 and 2017. At each sampling site, ten samples were collected using a benthos hand net. A total of 21 Odonata species was recorded. Odonata assemblages mainly consisted of common widespread species. Yet, at Vlačine Reservoir, located in the Dinaric Western Balkan ecoregion, we also recorded a rare and endangered Mediterranean species,Lindenia tetraphylla(Vander Linden, 1825). Aquatic and riparian vegetation, water level fluctuations and dissolved oxygen concentration had the highest influence on Odonata, showing that man-made water bodies with a well-developed riparian zone and aquatic vegetation, and with low daily and seasonal water level fluctuations, can provide suitable habitats for diverse Odonata species. Odonata are among the sensitive freshwater insects widely used as ecological indicators and umbrella species, therefore these results about their assemblages in heavily modified and man-made habitats could contribute to future conservation activities of freshwater biota and habitats.
Enseignement de la communication aux internes de médecine générale de la faculté de médecine, Paris Sud
Authors: Mercier Catherine , Arnould Pascale , Rainieri François
Published: March 2020

Contexte : L’enseignement de la communication aux étudiants en médecine a longtemps été négligé, bien que figurant dans les compétences visées par le cursus de formation universitaire. Le département de médecine générale de la faculté Paris Sud a mis en place, en 2014, un enseignement obligatoire se déroulant sur les trois années du cursus des internes du diplôme d’études spécialisées (DES). Cet enseignement progressif se déroule en deux modules. Le premier intègre des apports théoriques, en alternance avec des ateliers de mise en application, le second consiste en des ateliers filmés suivis de comptes rendus critiques. Objectif : Évaluer, chez les internes de première année, l’impact du premier module de formation de communication en termes de connaissances et de mise en application des outils ainsi que leur appréciation sur la formation reçue. Méthodes : Étude quantitative réalisée trois mois après la première session de formation. Les internes étaient invités à répondre à un questionnaire anonyme visant à évaluer leurs connaissances en matière de communication, leur capacité à les mettre en application en pratique hospitalière et leur évaluation du dispositif de formation. Résultats : Parmi 78 étudiants formés, 77 ont répondu à ce questionnaire. Plus de 75 % des étudiants se sont sentis en confort dans les exercices de simulation, ont observé des changements dans leur comportement communicationnel et pensent pouvoir intégrer ces outils dans leurs pratiques. Conclusion : À l’issue de cet enseignement, les internes sont demandeurs de ce type de formation dont ils disent observer les effets dans leur pratique.
Translating children’s literature of Ukrainian Diaspora as an implementation of the educational ideal of Ukrainian abroad
Authors: Vardanian Maryna
Published: March 2020

This essay examines the implementation of the educational ideal of Ukrainian Abroad in the Ukrainian Diasporic translation of children’s literature by such authors as Dhan Gopal Mukerji, Louis Henri Boussenard, Oscar Wilde, Daniel Defoe, Rudyard Kipling, etc. I claim that this ideal was formed in the 20th century in different cultural centers, united by Ukrainian World Congress. The Second Ukrainian World Congress approved main principles of the educational ideal in 1973, summarizing previous achievements. It is based on such human values as love, respect, and tolerance. All of these values got a Ukrainian sense. My focus in this article is on how these principles of the educational ideal are fulfilled in the translation of children’s literature of Ukrainian Diaspora.
Mathematical education at Kryvyi Rih State Pedagogical University: history, analysis of achievements and prospects of development
Authors: Kramarenko Tetiana , Korolskyi Volodymyr , Bobyliev Dmytro
Published: March 2020

The research deals with development of mathematical education at Kryvyi Rih State Pedagogical University (KSPU). The goal and objectives of the research include distinguishing and characterizing basic stages of formation and development of KSPU’s mathematical education, informing about the state of teaching, methodological, scientific and research activity, and defining prospects for developing the Department of Mathematics and Methods of its Teaching in future. By stages of developing mathematical education at KSPU, the authors mean periods of its 90-year development noted for certain peculiarities of organization and methods of training Mathematics teachers. Teaching, research and life dedicated to people are criteria that form the basis for determining basic stages in the Department of Mathematics’ development. A special edition Mathematical Education in Kryvyi Rih Pedagogical University: Personality Dimension was issued to honour the 90th anniversary of the Department of Mathematics after analyzing information from the University archive, museum and accessible personal data of Mathematics teachers “ University teachers, graduates and researchers. The data also concern their publications in ORCID and Google Scholar databases, the University repository, etc. There are characterized basic stages of developing mathematical education in the educational institution and its research trends.
Entrepreneurship education as a factor of society’s modernization
Authors: Korzhov Hennadii , Pasko Yaroslav
Published: March 2020

Entrepreneurship education (EE) is often regarded as one of the most important elements of the policy of stimulating small business and self-employment, creating start-ups and innovative business projects. The implementation of EE in the system of professional training at a new stage in the development of society could significantly increase the potential of using universities in the process of economic growth. The article sheds light on the nature and features of EE, analyzes the prospects and difficulties of its integration with other areas of training. The study demonstrates great prospects for the implementation of EE into the program of higher education training. EE has to be concentrated around several important characteristics of entrepreneurship and entrepreneurs themselves. The implementation of EE at the curriculum and extra-curriculum activities at the institutions of higher education of Ukraine, the combination of theoretical, problem- and project-oriented learning with the immersion into practical activities concerned with business planning, creating and running, training of students in groups together with nascent and experienced entrepreneurs would be extremely useful and productive in terms of motivating more and more young people to take an entrepreneurial path and achieve prosperity and selfactualization. The practical realization of EE will contribute to the formation of more resilient and competitive local communities as well as a more inclusive, just, equal, and happy society.
The theoretical foundations of the regional training program for teachers’ professional development “Education in conflict”
Authors: Trubavina Iryna , Tsybulko Liudmyla , Mohyliova Natalia , Ivanchuk Volodymyr
Published: March 2020

The article is devoted to the issue of developing professional skills of teachers working in a situation of a conflict. The purpose of the research is to substantiate the theoretical foundations of the course and to develop the content of a new training program for Ukrainian teachers’ professional development. The scientific novelty of the research lies in the content of the teachers’ professional development training program, which is grounded on a set of scientific approaches of different levels: philosophic, general scientific, specifically scientific, pedagogical approaches. The importance of children’s security assurance and warranty of their right to education in conflict is under our special consideration. The content of the program includes the following modules: 1) “Children’s problems caused by the armed conflict”; 2) “Education in conflict: the essence, standards (on the UNISEF and UNESCO information)”; 3) “Ways of implementation education in conflict in Ukraine”. The practical significance of the research lies in the multidisciplinary character of the regional training program “Education in conflict” and the recommendations to the methods of teaching it.
Systematicity of students’ independent work in the course of operating systems
Authors: Kolgatin Oleksandr , Holubnychyi Dmytro , Kolgatina Larysa
Published: March 2020

The paper is devoted to the study of systematicity of students’ learning activity as a parameter of student’s model, and influence of systematicity at learning results in the course “Operating Systems”. The necessity to equip the student himself as the subject of the educational process with the skills and appropriate pedagogical forecasting tools for independent choice of the appropriate variant of educational activity is shown as theoretical framework. Parameters of models in such pedagogical diagnostics system are suggested and discussed. Empirical work has been realised on the base of learning management system Moodle and give possibility to analyse correlation between timeliness of completing the learning tasks by students and their educational achievements as well as to analyse the structure of students’ time planning at homework. Recommendations to improve the educational process have been suggested
How to achieve students’ self-management in educational activity?
Authors: Bilousova Liudmyla , Kolgatina Larysa , Kolgatin Oleksandr
Published: March 2020

The paper is devoted to the study of types of managing the student’s educational activity. The educational discipline “Practicum of problem solving in informatics” for students of third year study, future teachers of informatics have been chosen for realising pedagogical conditions of computer-oriented management of students’ educational activity. Progressive turn from direct management through comanagement, subsidiary management to self-management was the main idea of designing the courseware. The information and communication educational environment has been based on the platform of learning management system Moodle. The Workshop elements of Moodle played the central role in management of students’ educational activity. The results of our pedagogical observation and assessment showed the efficiency of suggested approach. Additionally, there were shown the lack of students’ competency in time planning and introspection on the base of the experimental data.
Interactive methods of training for enhancing communication of IT-professionals
Authors: Symonenko Svitlana , Zaitseva Nataliia , Osadchyi Viacheslav , Vynogradova Margaryta
Published: March 2020

The paper deals with the issue of enhancing communication of IT-professionals using interactive training methods. It is emphasized that this problem is urgent for IT-education, which has the quickest rate of the content change, formation of new knowledge fields, shift in types and volumes of communication and interaction. Regulations, guides and qualifications frameworks of European countries and Ukraine in terms of requirements to communication of specialists in different fields have been analysed. The concepts of interactive teaching, interactive teaching methods and activities, and their advantages have been studied. It has been noted that interactive methods can be successfully used in teaching general and special subjects for future IT-professionals. Main peculiarities of certain interactive teaching methods have been described. Some practical ideas of the project method, brainstorming, the gamification method, the debate use in the educational process with the focus on the English language at higher educational institutions for enhancing better communication of IT-professionals have been presented. It is emphasized that the meticulous combination of interactive methods and preparation fosters comprehension at the sufficient level both in use of language aspects and in live communication.
The course “Development of virtual and AR software” for STEM teachers
Authors: Mintii Mykhailo
Published: March 2020

The article looks into the experience of development and using of learning resources for design of virtual reality (VR) and augmented reality (AR) systems for future STEM teachers. Unity environment for visual design, Visual Studio as a programming environment, platform of VR (Google VR) and AR (Vuforia) were chosen for development of teaching materials. The article describes the content of the created course. The research analyzes the impressions of the course participants. The research data were collected using interviews as the method of qualitative data collection. To conclude, the created course promotes the development of digital competence in the design and use of innovative learning tools.
Reduction of programs execution time for tasks related to sequences or matrices
Authors: Mitsa Oleksandr , Horoshko Yurii , Vapnichnyi Serhii
Published: March 2020

The article discusses three approaches to reducing runtime of the programs, which are solutions of Olympiad tasks on computer science, related to sequences or matrices. The first approach is based on the representation of some sequences in matrix form and then the program of calculating the members of the sequence will have asymptotics equal to the time complexity of the exponentiation algorithm and will be O(log (n)). The second approach is to upgrade the known code to obtain significant reduction of the program runtime. This approach is very important to know for scientists who write code for scientific researches and are faced with matrix multiplication operations. The third approach is based on reducing time complexity by search for regularities; the author's task is presented and this approach is used to solve it.
Einflussfaktoren auf die Haftfestigkeiten neuer und unterschiedlich recycelter Brackets
Authors: Wendl Brigitte , Muchitsch Peter , Jakse Norbert
Published: March 2020

Ziel der Arbeit war die Messung der Haftfestigkeiten neuer und unterschiedlich recycelter Brackets unter Verwendung verschiedener Kleber auf intakter Schmelzoberfläche und bei Wiederholungsklebung sowie die elektronenmikroskopische Beurteilung der Bracketbasen.
Klasse III interzeptive Behandlung: Ist die Gesichtsmaske das Mittel der Wahl? Ein Fallbericht
Authors: Kokkinos Petros P. , Feldner Josef A.
Published: March 2020

Der vorliegende Fallbericht zeigt ein alternatives Behandlungskonzept zur Therapie der Klasse III im Sinne einer interzeptiven Behandlung. Die 8 Jahre alte Patientin wies eine dentale und skelettale Klasse III auf. Die Behandlung erfolgte mittels laborgefertigten Overlays, die auf die Milchmolaren 75 und 85 gebondet wurden. Sie erfolgte basierend auf dem „Cybernetic Theory of Craniofacial Growth“ von Prof. Alexander Petrovic. Dadurch kommt es zu einer Vertikalisierung und Autorotation des Unterkiefers, durch welche sich ein dynamisches Verhältnis zwischen Ober-, Unterkiefer und den kranialen Schädelknochen einstellt. Zusätzlich zur Therapie der Klasse III wurde entschieden, schon eine leichte Lückenöffnung Regio 12 und 22 durchzuführen, um den Durchbruch der lateralen Schneidezähne zu gewährleisten.
Pilotstudie: Vergleich der Artefakte von Brackets mittels Dual-Energy-CT
Authors: Kasslatter Manuel , Glodny Bernhard , Grams Astrid , Crismani Adriano , Schieffer Lisa
Published: March 2020

Untersuchungen zur Anwendung der monochromen (MC) Bildgebung nach Implantation metallischer Materialien an den Extremitäten oder der Wirbelsäule haben gezeigt, dass dadurch verursachte Artefakte deutlich reduziert werden können. Aufgrund der hohen Ordnungszahlen und der hohen Dichte der in der Kieferorthopädie, Kieferchirurgie und Zahnerhaltung verwendeten Materialien stellen Aufhärtungsartefakte ein großes Problem bei der Computertomografie-Bildgebung (CT) der Zähne und des Kiefers dar. Die verursachten Einschränkungen der Bildqualität bei der Darstellung der Kiefer und denkbare Verbesserungsmöglichkeiten sind bisher unzureichend untersucht. Das Ziel dieser Arbeit war, die oben genannten Artefakte zu untersuchen und diese durch Erzeugung von Monochromen im Zahn- und Kieferbereich zu reduzieren. Dual-Energy-Computertomografien (DECTs) wurden an 10 Leichenköpfen mit und ohne kieferorthopädische Apparatur durchgeführt. Anschließend wurden MC von 80 bis 160 kV generiert. Die Artefakte wurden mit etablierten Methoden qualitativ und quantitativ beurteilt. An anatomischen Strukturen wie dem Mundboden und dem weichen Gaumen, die sich nicht in der gleichen axialen Ebene mit stark artefaktproduzierenden Objekten mit hoher Ordnungszahl befinden, konnte mit zunehmender kV-Zahl der MC eine Zunahme der Hounsfieldeinheiten (HE) beobachtet werden. An Strukturen in der gleichen Ebene mit artefaktproduzierenden Objekten konnte mit zunehmender kV-Zahl der MC eine Abnahme der HE beobachtet werden. Diese Studie zeigt, dass es auch im Kieferbereich möglich ist mittels MC Artefaktreduktion zu betreiben. In allen Untersuchungen konnten keine signifikant erhöhten Artefakte im Setting mit KFO-Apparatur im Vergleich zum Setting ohne KFO-Apparatur festgestellt werden.
Klasse-III-Behandlung mittels Multiloop Edgewise Archwire – ein Fallbericht
Authors: Kokkinos Petros P. , Feldner Josef A.
Published: March 2020

Der vorliegende Fallbericht zeigt die Therapie und das Behandlungskonzept eines Adoleszenten mit einer Klasse-III-Malokklusion. Der zum Start der Behandlung 17 Jahre alte Patient wies eine skelettale und dentale Klasse III auf. Es bestand ein Kreuzbiss bei den Zähnen 15 und 12–23, ein Kantbiss an den Zähnen 16, 14 und 13; der Zahn 13 war zusätzlich bukkal ausgeblockt. Die Therapie erfolgte mittels der von H. Kim in den frühen 1970er Jahren erstmals beschriebenen Multiloop Edgewise Archwire Technik.
Pre-Ablation rhTSH-Stimulated F-18 FDG PET/CT Changes Patient
Management in Increased-Risk Thyroid Cancer
Authors: Rendl Gundula , Rettenbacher Lukas , Schweighofer-Zwink Gregor , Hehenwarter Lukas , Pirich Christian
Published: March 2020

The aim of the study was to evaluate the clinical impact of pre-ablation
rhTSH-stimulated fluorine-18 fluorodeoxyglucose (F-18 FDG) PET/CT in
addition to post-therapeutic whole body radioiodine scanning in patients
with intermediate to high risk differentiated thyroid carcinoma (DTC). This
was a retrospective single center study including 73 patients with thyroid
cancer (44 females, mean age 43.2±16.2 years, 62% papillary,
31% follicular, 7% poorly differentiated). All patients
underwent ablative radioiodine treatment (mean activity: 3661±673
MBq I-131) using rhTSH after thyroidectomy and lymph node (LN) dissection
(01/2013–10/2016) and TSH-stimulated F-18 FDG
PET/CT (4 MBq/kg body weight, low dose CT). Post-treatment
I-131 whole body scan (I-131 WBS) was obtained 9 days afterwards in planar
technique and in case of equivocal or abnormal findings using
SPECT/CT. Thirty-one patients (42%) showed F-18 FDG avid
lesions, 14 patients showed more FDG than iodine positive lesions and 5
patients more iodine positive lesions in I-131 WBS, respectively.
Fifty-three patients showed identical F-18 FDG PET/CT and I-131 WBS.
The initial treatment plan was changed from follow-up to therapy (surgery,
systemic therapy using tyrosine-kinase inhibition) in 11 patients
(15%) on the basis of F-18 FDG PET/CT imaging. Six of these
11 patients had papillary thyroid cancer. Three patients with histologically
proven LN metastases had stimulated
thyroglobulin-levels<2.0 ng/ml. Our study
demonstrated a clinical benefit of pre-ablation rhTSH-stimulated F-18 FDG
PET/CT imaging in about 20% of patients with intermediate to
high risk DTC, leading to change in patient management in 15%.
Effect of Intravenous 25OHD Supplementation on Bone Turnover and
Inflammation in Prolonged Critically Ill Patients
Authors: Ingels Catherine , Vanhorebeek Ilse , Van Cromphaut Sophie , Wouters Pieter J. , Derese Inge , Dehouwer Alexander , Møller Holger Jon , Hansen Troels K. , Billen Jaak , Mathieu Chantal , Bouillon Roger , Van den Berghe Greet
Published: March 2020

Critically ill patients have low circulating 25-hydroxyvitamin D (25OHD),
vitamin D binding protein (DBP), and 1,25-dihydroxyvitamin D
[1,25(OH)2D]. Low 25OHD is associated with poor outcomes,
possibly explained by its effect on bone and immunity. In this prospective,
randomized double-blind, placebo-controlled study, we investigated the
feasibility of normalizing 25OHD in prolonged (>10 days) critically
ill patients and the effects thereof on 1,25(OH)2D, bone
metabolism, and innate immunity. Twenty-four patients were included and
compared with 24 matched healthy subjects. Patients were randomized to
either intravenous bolus of 200 μg 25OHD followed by daily
infusion of 15 μg 25OHD for 10 days, or to placebo.
Parameters of vitamin D, bone and mineral metabolism, and innate immune
function were measured. As safety endpoints, ICU length of stay and
mortality were registered. Infusion of 25OHD resulted in a sustained
increase of serum 25OHD (from median baseline
9.2 –16.1 ng/ml at day 10), which,
however, remained below normal levels. There was no increase in serum
1,25(OH)2D but a slight increase in serum
24,25(OH)2D. Mineral homeostasis, innate immunity and
clinical safety endpoints were unaffected. Thus, intravenous 25OHD
administration during critical illness increased serum 25OHD concentrations,
though less than expected from data in healthy subjects, which suggests
illness-induced alterations in 25OHD metabolism and/or increased
25OHD distribution volume. The increased serum 25OHD concentrations were not
followed by a rise in 1,25(OH)2D nor were bone metabolism or
innate immunity affected, which suggests that low 25OHD and 1,25OHD levels
are part of the adaptive response to critical illness.
Diabetes, Sport und Bewegung
Authors: Esefeld Katrin , Heinicke Verena , Kress Stephan , Behrens Meinolf , Zimmer Peter , Stumvoll Michael , Brinkmann Christian , Halle Martin
Published: March 2020

Bewegung ist für alle Formen des Diabetes mellitus eine der wichtigsten Maßnahmen, die Gesundheit zu erhalten. Durch Sport und Bewegung werden Anpassungs- und Reparaturmechanismen in verschiedenen Organsystemen und Zellen wie der Muskulatur, den Nerven, Gefäßen, im Immunsystem oder Gehirn ausgelöst, die helfen können, Krankheiten abzuwehren 1, 2, 3, 4.
Imaging of otosclerosis
Authors: Kösling Sabrina , Plontke Stefan K , Bartel Sylva
Published: March 2020

Background Otosclerosis is an important cause of hearing loss and a widespread pathology in ENT medicine. Although a high diagnostic value of CT with impact on therapy is emphasized in the literature, the disease is seldom seen in the radiological routine diagnostics due to ENT findings often being diagnostic. Radiologists detect it rather more often in cases of unclear hearing loss or cochlear implant candidates. The findings may be very subtle. They require a target search and an optimal imaging technique.

Methods This review article is based on a selective search of the literature in PubMed without any time frame restrictions as well as on the long clinical experience of the authors.

Results The paper focuses on imaging aspects of otosclerosis: current role, advice for imaging technique, characteristic imaging signs, radiological differential diagnoses and findings after stapedoplasty. Pathology, clinical signs and therapeutic options are summarized briefly.

Conclusions With an optimal technique and sufficient radiological experience otosclerosis can be correctly diagnosed by imaging in a high percentage of cases. Radiology plays the key role in the diagnosis of retrofenestral otosclerosis. It can provide valuable information for the management of complications after stapedotomy.

Key points: 

Citation Format
Mn(III)-Mediated Facile Access to Polysubstituted α-Naphthols from β-Keto Ester Derivatives and Terminal Alkynes
Authors: Yang Yuzhu , Pan Weidong , He Lisheng , Li Fei , Liu Xiaolan
Published: March 2020

A novel manganese-mediated reaction for the synthesis of polysubstituted α-naphthols has been developed from β-keto esters and terminal alkynes. This system holds the advantages of readily available starting materials and mild conditions. Mechanistic investigations revealed that this reaction proceeds via a tandem radical cyclization process.
Genomics and Interventional Oncology in Primary Liver Cancer
Authors: Slovak Ryan , Dendy Case Meaghan , Kim Hyun S.
Published: March 2020

Personalized medicine is revolutionizing oncologic care. Molecular and imaging “fingerprinting” of cancer through genomics, radiomics, and radiogenomics has allowed for the meticulous characterization of many forms of malignancy, including primary liver cancers. With this data, treatments are being developed that precisely target and exploit key variations in individual tumors. As these methods continue to evolve, interventional oncologists are well positioned to capitalize on the advances being made. This article will provide a concise overview of the genomic, radiomic, and radiogenomic research on hepatocellular carcinoma and intrahepatic cholangiocarcinoma, in addition to discussions on how precision medicine would relate to interventional oncology.
KIS MARKT IM UMBRUCH: Medico geht an die CompuGroup
Authors: Heeser Alexandra
Published: March 2020

Bereits seit einam halben Jahr wird über den Verkauf des Krankenhausinformationssystems (KIS) Medico spekuliert. Jetzt ist es amtlich: Die CompuGroup Medical SE übernimmt Teile des IT-Healthcare Portfolios von Cerner in Deutschland und Spanien und zahlt dafür 225 Millionen Euro.
kma ENTSCHEIDER BLOG: Die neue Rolle der Chefärzte
Authors: Heurich Manuel
Published: March 2020

Zunehmende Qualitätsmessung, wirtschaftlicher Druck, mündige Patienten und nicht zuletzt Mitarbeiter, die eine gute Work-Life-Balance fordern: Faktoren, die den Job des Chefarztes nicht gerade einfacher machen. Die neue Rolle der Chefärzte ist herausfordernd aber auch äußerst attraktiv und spannend.
KLINIK UNTERNEHMEN: AUF-/ABSTEIGER DES MONATS
Authors: Schmidt Hartmut
Published: March 2020

Borsenexperte Hartmut Schmidt analysiert fur kma die Jahresabschlusse ausgewahlter Kliniken
DMEA 2020: „Wir sind auf dem Weg nach oben“
Authors: Doelfs Guntram
Published: March 2020

Europas größtes Event für digitale Gesundheit will nach dem erfolgreichen Neustart 2019 weiter wachsen. Sebastian Zilch, Geschäftsführer des DMEA-Veranstalters BVITG, spricht in kma über die Highlights und Neuerungen der diesjährigen DMEA – und warum ein heißer Stuhl die DMEA bereichert.
RECRUITING 2.0: Geschwindigkeit ist Trumpf
Authors: Holldorf Lars
Published: March 2020

Fachkräftemangel ist für die meisten Krankenhäuser nichts Neues. Entsprechend steigen die Aufwände für die Personalgewinnung weiter. Ein Blick auf die Karriere-Webseiten vieler Krankenhäuser und deren interne Prozesse zur Personalgewinnung zeigt allerdings auch noch erheblichen Nachholbedarf und „Modernisierungsstau“.
CHIEF INFORMATION SECURITY OFFICER: Steuermann durch den IT-Sicherheitsprozess
Authors: Schütz Thorsten
Published: March 2020

Ohne funktionierende IT steht ein Krankenhaus weitgehend still, das belegen zahlreiche Beispiele von Hackerangriffen. Damit ein solcher Fall nicht eintritt, brauchen Krankenhäuser redundante IT-Systeme, ein fehlerfreies Zusammenspiel der eingesetzten Anwendungssysteme sowie einen wirksamen Schutz gegen Cyberattacken. Und: einen CISO.
KLINIK-EINKAUFSGEMEINSCHAFTEN: Gemeinsam einkaufen – gemeinsam sparen
Authors: Kempe Lisa
Published: March 2020

Der Markt der Klinik-Einkaufsgemeinschaften ist in Bewegung. Die Gesellschaften, ihre Mitglieder und Kunden ebenso wie ihre Lieferanten müssen sich jetzt der Digitalisierung auf allen Ebenen stellen. Der Trend geht dabei von der reinen Einkaufs- zur Dienstleistungsgemeinschaft.
PATIENTENENTERTAINMENT: Kinofilm statt Vollnarkose
Authors: Kucera Martin
Published: March 2020

Um Patienten von ihren Ängsten zu befreien, greifen Kliniken vor MRT-Untersuchungen oder anstehenden Operationen gern zur Vollnarkose. Einige Krankenhäuser zeigen mittlerweile, dass es auch anders geht. Das spart nicht nur Beruhigungsmittel, sondern ist auch ein Wettbewerbsfaktor.
KLINIK-SMARTPHONES: Schnelle Hilfe dank moderner Kommunikation
Authors: Jendrysiak Udo
Published: March 2020

Wenn Patienten oder Angehörige in der Notaufnahme randalieren, wenn ein Patientenmonitor einen Herzstillstand meldet oder ein Rauchmelder einen Entstehungsbrand, ist schnelles Handeln angesagt. Smartphones können auch im Klinikbereich dazu beitragen, dass Alarme schnell die Richtigen erreichen und keine Zeit vergeudet wird.
Insecurity, Dispossession, Depletion: Women’s Experiences of Post-War Development in Myanmar
Authors: Hedström Jenny , Olivius Elisabeth
Published: March 2020

This article explores the gendered dynamics of Myanmar’s post-war economic reforms through an analysis of women’s experiences of development in Kayah (Karenni) state. In Myanmar, ceasefires and a reduction of armed violence combined with state-driven economic liberalization reforms are conditioned by, but also contribute to remake, gendered relations of power, privilege and marginalization. While new land legislation and development projects have contributed to loss of land and livelihoods among rural populations in general, our study demonstrates that women living in conflict-affected border areas are disproportionally affected. Drawing on interviews and participant observation, we show how this is directly related to an overarching gendered political economy defined by legacies of conflict, discrimination and uneven processes of development, which positions women as particularly vulnerable to new forms of insecurity, dispossession and depletion generated by post-war economic transformations. We argue that the political and economic legacies of war in the state has produced a gendered division of labor that positions women as responsible for unpaid and underpaid informal and social reproductive labor, weakens women’s access to land, and results in physical, material, and emotional depletion. Through this focus, our study adds to research on development and economic restructuring in post-war contexts in general, and to emergent scholarship on Myanmar’s economic reforms in particular.
Approximate equation-of-motion coupled-cluster methods for electron affinities of closed-shell molecules
Authors: Ma Fengjiao , Wang Zhifan , Guo Minggang , Wang Fan
Published: March 2020

We investigate performance of the equation-of-motion coupled-cluster method at the single and doubles level (EOM-CCSD) and a series of approximate methods based on EOM-CCSD on electron affinities (EA) of closed-shell cations and neutral molecules with positive and negative EAs in this work. Our results confirm that P-EOM-MBPT2 can provide reasonable EAs when molecules with significant multireference character are not considered and its mean absolute error on EAs of these molecules is around or less than 0.2 eV. Its accuracy is comparable to that of the more expensive EOM-CCSD(2) method. Results of EOM-CCSD(2), P-EOM-MBPT2, and CIS(D∞) indicate that the [[H, ac+], T2] term in the 1h2p–1h block is more important on EAs than the term neglected in the 1h2p–1h2p block in P-EOM-MBPT2. We proposed an economical method where EAs from CIS(D∞) are corrected by treating this [[H, ac+], T2] term in the 1h2p–1h block perturbatively [corr-CIS(D∞)]. EAs with corr-CIS(D∞) agree very well with those of P-EOM-MBPT2 with a difference of less than 0.02 eV. Computational scaling of this method is N4 for the iterative part and N5 for some non-iterative steps. Its storage requirement is only of OV3. Corr-CIS(D∞) is an economical and reliable method on EAs, and it can be applied to EAs of large molecules.
Ellipsoidal mirror offers an alternative method to focus soft x-ray
Authors: Mandel Savannah
Published: March 2020

Using an ellipsoidal mirror to focus soft x-rays is efficient, avoids chromatic aberration and can be used for many different types of microscopy.
Gariwerd
Authors: Wilkie Benjamin
Published: March 2020

People have been visiting and living in the Victorian Grampians, also known as Gariwerd, for thousands of generations. They have both witnessed and caused vast environmental transformations in and around the ranges. Gariwerd: An Environmental History of the Grampians explores the geological and ecological significance of the mountains and combines research from across disciplines to tell the story of how humans and the environment have interacted, and how the ways people have thought about the environments of the ranges have changed through time.
In this new account, historian Benjamin Wilkie examines how Djab wurrung and Jardwadjali people and their ancestors lived in and around the mountains, how they managed the land and natural resources, and what kinds of archaeological evidence they have left behind over the past 20 000 years. He explores the history of European colonisation in the area from the middle of the 19th century and considers the effects of this on both the first people of Gariwerd and the environments of the ranges and their surrounding plains in western Victoria. The book covers the rise of science, industry and tourism in the mountains, and traces the eventual declaration of the Grampians National Park in 1984. Finally, it examines more recent debates about the past, present and future of the park, including over its significant Indigenous history and heritage.
Future of the Fringe
Authors: Buxton Michael , Butt Andrew
Published: March 2020

Peri-urban landscapes are some of the world’s most vulnerable areas. Although they are often thought of simply as land awaiting development, these landscapes retain important natural resources and make valuable contributions to agriculture, water use, biodiversity conservation, landscape preservation and human well-being. Billions of people use them and enjoy their natural values. Their continuing loss threatens to alter our relationships with nature and have a negative impact on the environment.
The Future of the Fringe first explores the history of peri-urban areas, international peri-urban policy and practice, and related concepts. It analyses internationally relevant issues such as green belts and urban growth boundaries, regional policy, land supply and price, and the concepts of liveability, attractiveness, well-being and rural amenity. It then examines a range of Australian peri-urban issues, as an extended case study. The book argues for a precautionary approach so that we retain the greatest number of options to adapt during rapid and unprecedented change.
Ectopic expression of a R2R3 MYB transcription factor of dove tree (Davidia involucrata) aggravates seed abortion in Arabidopsis thaliana
Authors: Li Jian , Chen Tian , Huang Fengzhen , Dai Penghui , Cao Fuxiang , Li Meng
Published: March 2020

Serious seed abortion of dove tree (Davidia involucrate Baill.) is one of the critical factors leading to the low fecundity of this species. Seed abortion is a complicated process and various factors have been verified to synergistically determine the fate of seeds. To reveal the mechanism of seed abortion in D. involucrata, we performed transcriptome analysis in normal and abortive seeds of D. involucrata. According to the transcriptome data, we noticed that most of the genes encoding a MYB transcription factor were predominantly expressed in abortive seeds. Among these, a gene named DiMYB1 was selected and its function was validated in this study. Overexpression of DiMYB1 resulted in obviously reduced viability of transgenic seeds and seedlings, and caused a significantly higher seed abortion rate. The vegetative growth of transgenic plants was hindered, resulting in an earlier flowering time. In addition, colour changes occurred in transgenic plants. Some transgenic sprouts, stems and pods appeared purple instead of green in colour. Our finding demonstrated that DiMYB1 participates in multiple plant developmental processes, especially in seed development in Arabidopsis thaliana (L.) Heynh., which indicated the similar role of this gene in D. involucrata.