bluuebunny/crossref_metadata_2025 huggingface dataset:
Standardized CT Value: A Promising Diagnostic Parameter to Differentiate Lipid and Fibrous Coronary Plaques
Authors: Gao Yaqi , Pan Yao , Jia Chongfu , Wu Wei , Wang Zhaoqian , Zhang Yuepeng , Wang Hao , Hui Hui
Published: January 2023

Purpose
To evaluate the accuracy of the standardized CT value in differentiating between lipid-rich and fibrous coronary plaques and to examine the stability of its cutoff preliminarily.
Methods
Patients who underwent both coronary computed tomographic angiography (CCTA) and intravascular ultrasound (IVUS) were included. The CT values of the plaque assessed from all, four, and two short-axis slices were acquired. We defined the standardized CT value as the Hounsfield unit (HU) ratio of the plaque to the ascending aorta. The nature of the plaques was determined by IVUS. The receiver operating characteristic curve was applied to determine the diagnostic performance of the standardized and traditional CT values.
Results
A total of 60 patients with 74 plaques were included. 35 lipid-rich plaques and 39 fibrous plaques were diagnosed by IVUS. The CT value of the aorta showed a strong correlation with plaques (r = 0.420, P < 0.01). The threshold CT values differentiating the plaque types on all-slice, four-slice, and two-slice were 55 HU, 48 HU, and 52 HU, and the threshold of the standardized CT value was consistently 0.149. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of the four-slice CT values differentiating lipid and fibrous plaques were 69%, 87%, 83%, 76% and the corresponding standardized CT values were 91%, 82%, 82% and 91%.
Conclusions
Compared with traditional CT values, standardized CT values can significantly improve the sensitivity and NPV for differentiating between lipid-rich and fibrous coronary plaques while achieving moderate to high specificity and PPV. Furthermore, the cutoff is stable.
Effective clearance of rituximab-resistant tumor cells by breaking the mirror-symmetry of Immunoglobulin G and simultaneous binding to CD55 and CD20
Authors: Lee Sang Min , Min Sung-Won , Kwon Hyeong Sun , Bae Gong-Deuk , Jung Ji Hae , Park Hye In , Lee Seung Hyeon , Lim Chung Su , Ko Byoung Joon , Lee Ji Chul , Jung Sang Taek
Published: January 2023

Complement dependent cytotoxicity (CDC), which removes aberrant target cells through the assembly and complex formation of serum complement molecules, is the main effector function of anticancer therapeutic antibodies. In this study, we found that the CDC activity of anti-CD20 antibody increased remarkably when the symmetry of natural Immunoglobulin G (IgG) antibodies was broken. In addition, the expression of CD55 (a checkpoint inhibitor in the CDC cascade) was significantly increased in an in-house constructed rituximab-resistant cell line, suggesting that CD55 overexpression might be a mechanism by which cancer cells acquire rituximab resistance. Based on these findings, we developed an asymmetric bispecific antibody (SBU-CD55×CD20) that targets both CD55 and CD20 simultaneously to effectively remove rituximab-resistant cancer cells. In various cancer cell lines, including rituximab-resistant lymphoma cells, the SBU-CD55×CD20 antibody exhibited significantly higher CDC activity than either anti-CD20 IgG antibody alone or a combination of anti-CD20 IgG antibody and anti-CD55 IgG antibody. Furthermore, compared with other bispecific antibodies with symmetric features, the asymmetric bispecific antibody (SBU-CD55×CD20) exhibited significantly higher CDC activity against rituximab-resistant cancer cells. These results demonstrate that improving CDC using an asymmetric CD55-binding bispecific antibody could be a new strategy for designing therapeutics to treat patients with relapsed or refractory cancers.
Klinische und neuropsychologische Vorteile der Resektion von Tumoren im Corpus callosum
Authors:   , Forster Marie-Therese Johanna
Published: January 2023

Hintergrund. Patienten mit Gliomen, die das Corpus callosum miteinbeziehen, befinden sich häufig in einem schlechten neurologischen Zustand und werden aufgrund der Antizipation postoperativer neurologischer und neurokognitiver Defizite nur selten einer Tumorresektion unterzogen. Ziel der Arbeit. Zielsetzung dieser Arbeit war die Untersuchung eines möglichen Vorteils der Resektion von Gliomen im Corpus callosum, unter der Annahme, dass neurokognitive Defizite vor allem durch den Tumor selbst verursacht werden. Material & Methoden. In diese prospektive Studie wurden zwischen 01/2017 und 01/2020 21 Patienten eingeschlossen, die eine Gliomresektion im Corpus callosum erfuhren. Klinische Routinedaten als auch die neurokognitiven Funktionen der Patienten wurden prä- und postoperative sowie nach 6 Monaten erhoben. Ergebnisse. In 15 Patienten konnte eine Komplettresektion, in 6 Patienten eine subtotale Resektion mit einem Resektionsausmaß von 97,7% erzielt werden. Während der medianen Beobachtungszeit von 12,6 (2,0 – 30,9) Monaten starben 8 Patienten mit einem Glioblastom ZNS WHO Grad 4 und 1 Patient mit einem Astrozytom ZNS WHO Grad 4 nach im Median von 17 (3,8 – 20,6) Monaten, während 12 Patienten nach im Median 9,4 (2,0 – 30,9) Monaten noch am Leben waren. Präoperativ wiesen bis zu zwei Drittel aller Patienten Beeinträchtigungen in allen kognitiven Domänen auf, trotz eines medianen Karnofsky Performance Scores von 100% (Spanne 60-100%). Postoperativ wurde in allen neurokognitiven Domänen ein zunehmender Anteil an Patienten mit Einschränkungen beobachtet. Nach 6 Monaten zeigte sich jedoch, dass signifikant weniger Patienten Beeinträchtigungen in den Domänen Aufmerksamkeit, Exekutivfunktionen, Gedächtnis und Depression aufwiesen – Funktionen, die für den Alltag der Patienten von höchster Bedeutung sind. Fazit. Die Resultate dieser Studie unterstützen unsere Hypothese, dass für Patienten mit Gliomen, die das Corpus callosum miteinbeziehen, der Vorteil einer Tumorresektion das Risiko neuer Defizite überwiegt.
COVID-19 MANIFESTATION IN A CHILD WITH LUNG METASTASES OF OSTEOSARCOMA: A CASE REPORT
Authors: Saputra Yulwhinar Cego
Published: January 2023

Background: COVID-19 (Corona virus disease-19) is an infectious disease caused by a new type of corona virus which in the same group of the virus that causes Severe Acute Respiratory Syndrome (SARS), where the incubation period for infection is 1-14 days or up to 24 days, accompanied by symptoms of a respiratory tract infection and other organ systems. The number of recent cases in November 2020 was 59.8 million worldwide. Elderly patients and people with comorbid diseases are at high risk of developing severe manifestations of this viral infection. Osteosarcoma is a deadly bone cancer that often causes patients to die from metastases to the lungs Purpose: The purpose of this study is to report cases of COVID-19 in a 9-year old child patient with a history of osteosarcoma at Bethesda Hospital Yogyakarta. Case Description: A 9-year old female patient came to the emergency room complaining of fever, cough, severe chest pain, and shortness of breath since 3 weeks before being admitted to the hospital. The patient had a past medical history of osteosarcoma since 1.5 years before being admitted to the hospital and an amputation procedure on the right arm was carried out, no specific illness in the family history was found. The general condition of the patient appears to be moderate with delirium consciousness (E4V6M1). Vital sign examination showed a pulse rate of 130 beats per minute, an oxygen saturation of 85% and a breath rate of 30 beats per minute. CT scan without contrast shows a massive left pleural effusion, malignancy/metastatic mass of the left lung, with pneumonic opacity in the right lung. Conclusion: COVID-19 is an infectious disease caused by SARS-CoV-2 and causes severe manifestations in patients with comorbid diseases including pulmonary metastases. CT-Scan modalities are used as a basis for diagnosis other than RT-PCR. Management of COVID-19 is in the form of supportive therapy based on the degree of disease severity.
ABCC8 EXON 16-3 C>T POLYMORPHISM IS ASSOCIATED WITH INSULIN SECRETION IN PATIENTS WITH TYPE 2 DIABETES IN YOGYAKARTA
Authors: Dwi Pratiwi Johana puspasari
Published: January 2023

Background ABCC8 is a gene encoding the SUR1 subunit of the KATP Channel which plays a central role in insulin secretion from the beta cell, hence its potential as the candidate risk gene in the development of type 2 Diabetes Mellitus (DM type 2). the polmorphism of ABCC8 exon 16 -3 C>T has been investigated in various populations with inconsistent result. Therefore, this study aimed to explore the association of the polymorphism with DM type 2 in Yogyakarta population. Method a number of 40 patients with DM type 2 and 44 patients without DM type 2 were recruited as case and control subjects, respectively. the polymorphism was genotyped using PCR-RFLP. The association between insulin secretion and the polymorphism was analyzed with ANOVA and Post Hoc Test. Chi-square and odds ratio were employed to determine whether the polymorphism was a risk of DM type 2. Results There was a significant difference between CC and CT genotypes among subjects with DM type 2 (p=0,005). Fasting insulin concentration exhibited a significant difference between CC and TT genotypes among DM type 2 subjects (p=0,013). Allele T frequency was found to be 0,45 among DM type 2 subjects and 0,48 among non DM subjects, there was no significant difference of allele T frequency between DM type 2 and non DM subjects (p=0,723, OR=0,90, CI: 0,49-1,65). Conclusion ABCC8 exon 16 -3 C>T polymorphism was not associated with DM type 2 prevalency in Yogyakarta population, however the impact of the polymorphism on diabetes pathogenesis in DM type 2 can not be excluded because of the association with insulin secretion in DM type 2 subjects.
Case Report Tuberculous Spondylitis in Elderly with Polyneuropathy
Authors: Laraswati Isabella Diah Ayu , Hansen Lie Adityo
Published: January 2023

Background Tuberculous (TB) spondylitis or Pottâ€™s Disease is a manifestation of extrapulmonary tuberculosis infection caused by the hematogenous and lymphomatous spread of Mycobacterium Tuberculosis, causing infection in the vertebral bones. Approximately 10% of extrapulmonary TB cases are TB spondylitis. Pulmonary and extrapulmonary tuberculosis cases are considerable cases in developing countries. Indonesia is a country with the third-highest prevalence of TB in the world after China and India.Objective The aim of this study was to report a case of TB spondylitis in a 66 years old woman with polyneuropathy at Bethesda Hospital Yogyakarta.Case description A 66 years old female patient presented with complaints of pain and difficulty in moving the left lower limb 3 months ago. The patient had a history of hypertension 5 years ago, while the family history was not specific. The patient was generally in pain with full awareness and cooperation. Vital sign examination showed blood pressure 140/80 mmHg, pulse 82 beats per minute, and respiratory rate of 22 breaths per minute. The lumbosacral-MRI examination was performed without contrast material and L2-L5 TB Spondylitis, with L2-L3 Disc protrusion, was found.Conclusion Tuberculous spondylitis (TB) may cause paradiscal inflammation, edema, and progressive bone destruction due to lysis of anterior bone tissue and secondary ischemia which will lead to collapse. Pain, difficulty moving, and local swelling are the most common complaints. Abnormalities in the curvature, misalignment of the vertebrae, deformity and bone destruction might be found in MRI radiological imaging. Treatment of TB spondylitis prioritizes administering of anti-TB drugs combined with immobilization using a girdle. The prognosis for TB spondylitis varies depending on the clinical manifestations.
The Relationship of Various Risk Factors with LBW in South Tangerang City General Hospital for the Period March-October 2021
Authors: Levita Sharon , Langi Louisa
Published: January 2023

Background Low birth weight (LBW) is a serious child health problem that requires global attention, especially in developing countries or with low economic status. Indonesia itself is in the ninth position of the country with the highest prevalence of LBW in the world. Therefore, it is important to examine various factors that can increase the risk of LBW, and it is hoped that it can prevent the occurrence of LBW, considering the complications that LBW can experience in both the short and long term.Objectives This study aims to determine the relationship between various risk factors and LBW in South Tangerang City General Hospital for the period March-October 2021.Methods This study is an analytical observational study using the cross-sectional method. Sources of data were obtained from medical records and books on Maternal and Child Health (KIA) of respondents, with the criteria of respondents being mothers with a history of giving birth to low birth weight (<2500 g), having an active cell phone number and recorded in the NICU registration at South Tangerang City General Hospital, and still having Maternal and Child Health (KIA) book.Results There was a significant relationship between risk factors for gestational age (p=0.046) and frequency of ANC visits (p=0.035) with low birth weight, but there was no significant relationship between risk factors for maternal age (p=0.193), maternal education (p=0.087), maternal occupation (p = 0.618), and family income (p = 0.320) with low birth weight in South Tangerang City General Hospital for the period March-October 2021.Conclusion Gestational age and frequency of ANC visits are statistically significant risk factors for LBW incidence in South Tangerang City. Maternal age, maternal education, mother's occupation, and family income are not statistically associated with low birth weight in South Tangerang City General Hospital
NONCOMMUNICABLE DISEASES PREVALENCE AND HEALTH-POST ATTENDANCE ASSOCIATED FACTORS IN AN URBAN SLUM AND A MIDDLE-INCOME COMMUNITY
Authors: Astiarani Yunisa , Kristian Kevin , Fitriah Nur
Published: January 2023

Background Non-communicable Diseases (NCDs) become the leading cause of death, particularly in low-income settings. However, the health post for NCDs called Pos Pembinaan Terpadu (Posbindu) aimed to be the screening post in the community loses its function due to residentsâ€™ low visitation.Objective This study aimed to investigate NCDâ€™s prevalence in low-middle income communities and analyzed health-post attendance associated factors in two areas with different socioeconomic backgrounds.Methods A community survey was conducted on a slum and a middle-income hamlet in Pejagalan village. A total of 470 residents aged 15 and above responded to the demographic and NCDs risk factors questionnaire. Logistic regression was performed separately in the two areas.Results The prevalence of NCDs and its multimorbidity are presiding in the slum, while the health-post attendance in the area associated with women visitors (odds ratio [OR]=4.2; 95% confidence interval [CI]=1.9-9.1), the 30-59 age group (OR=5.0; 95%CI=2-10), having no education (OR=4.7; 95%CI=1.9-5.5), unemployed (OR=2.5; 95%CI=1.3-5.7), and practicing a less-fat diet (OR=3.2; 95%CI=1.7-6.0). The elderly were less likely to visit the posts (OR=0.3; 95%CI=0.1-0.9). Meanwhile, increasing age (OR=1.03; 95%CI=1.01-1,05), residents who practice regular physical activity (OR= 2.3; 95% CI=1.3-4.1), and not smoking (OR=2.9; 95%CI=1.4-6.0) were associated with community health-post attendance in middle-income hamlet.Conclusion The results indicated that NCDs prevalence in the slum needs proper attention, particularly in elderly and male residents, due to low visits to the health post. Enhancing the specific target of NCDs screening respective to the areas would be the best effort to prevent further NCDs prevalence.
Metode Penanaman Karakter Santri dan Santriwati TK dan TPA Al-Futuhiyyah Banjarmasin
Authors: Rasyidi Ahyar , Dwina Dwina
Published: January 2023

This study seeks to reveal the method of cultivating the character of Santri and Santriwati Kindergarten/TPA Al-Futuhiyyah Banjarmasin City and its supporting and inhibiting factors. This study also aims to describe the Santri and Santriwati Character Cultivating Methods for Kindergarten/TPA Al-Futuhiyyah Banjarmasin City and find the supportive and inhibiting factors. This research method is classified as field research. At the same time, the approach used is descriptive-qualitative, namely by explaining events directly based on direct observation at the location and object of research. The subjects of this research were teaching staff. This study was the Method of Instilling the Character of Santri and Santriwati Kindergarten/TPA Al-Futuhiyyah Banjarmasin City. This study uses the method of observation, interviews, and documentation. From the results of this study, several findings were obtained that the method used by the teacher in cultivating the character of students and female students was effective through integrating knowledge and charity in daily activities. The factors that support the cultivation of character are the educational background of teachers who incidentally come from Islamic boarding schools and are pursuing an undergraduate degree at PTKIN/PTKIS in Banjarmasin, as well as a conducive family environment. Meanwhile, the inhibiting factor in cultivating character is part of the students' family environment, especially parents who are less proactive in paying attention to changes in children's attitudes, as well as the influence of association with peers, which then has a negative effect on the formation of their character.
Pengaruh Fasilitas Belajar Terhadap Motivasi Belajar Siswa Kelas V di MI Al-Mujahidin Samarinda
Authors: Asriani Nur , Mujahidah Mujahidah , Saugi Wildan
Published: January 2023

Ketersediaan dan kelengkapan fasilitas belajar akan memudahkan siswa untuk belajar sehingga siswa akan terdorong dan semangat untuk belajar. Penelitian ini bertujuan 1) untuk mengetahui apakah ada pengaruh fasilitas belajar terhadap motivasi belajar siswa kelas V di MI Al-Mujahidin Samarinda; 2) untuk mengetahui seberapa besar pengaruh fasilitas belajar terhadap motivasi belajar siswa kelas V di MI Al-Mujahidin Samarinda. Jenis penelitian ini adalah penelitian kuantitatif. Populasi penelitian ini adalah seluruh siswa kelas V yang berjumlah 42 peserta didik yang terdiri dari kelas Va dan Vb di MI Al-Mujahidin Samarinda, maka keseluruhan populasi di ambil sebagai sampel penelitian. Teknik pengumpulan data yang digunakan yaitu angket dan dokumentasi. Teknik uji coba instrumen terdiri dari dua bagian yaitu uji validitas dan uji reliabitas. Untuk teknik analisis data peneliti menggunakan uji prasyarat yang didalamnya terdapat uji normalitas dan uji linieritas, uji korelasi product moment, uji koefisien determinasi dan uji hipotesis. Berdasarkan hasil analisis data diketahui bahwa ada pengaruh positif antara fasilitas belajar terhadap motivasi belajar siswa kelas V di MI Al-Mujahidin Samarinda sebesar 0,764, bila dikonsultasikan dengan tabel interpretasi r berada di antara 0,70-0,90 berarti berada pada kategori kuat. Sedangkan hasil koefisien determinasi sebesar 0,584 atau 58,4% dan sisanya 41,6% ditentukan variabel lain yang tidak diketahui dan pembuktian hipotesis dengan menguji signifikansi menggunakan rumus uji t, diperoleh hasil t-hitung > t-tabel (7,492 > 1,683) artinya hipotesis yang dikemukakan terdapat pengaruh signifikan antara fasilitas belajar terhadap motivasi belajar siswa kelas V di MI Al-Mujahidin Samarinda, sehingga Ha diterima dan Ho ditolak.
Gen-Z Muslims’ purchase intention of halal food: Evidence from Indonesia
Authors: Rizqi Febriandika Nur , Wijaya Vamel , Hakim Lukmanul
Published: January 2023

Halal food production is a crucial sector for Muslims, especially Generation Z, who spend time eating in stalls and restaurants instead of eating homemade food. This tendency is higher than in the previous generation. Thus, this study aims to estimate the factors influencing the purchase intention of halal food for Generation Z Muslims in Indonesia. This quantitative study uses a questionnaire distributed randomly online to 352 respondents. Data analysis and hypotheses were examined using the structural equation model (SEM) approach. The results show that religious belief, exposure, and health reasons are essential in increasing halal awareness. Meanwhile, halal awareness and knowledge positively contributed to increasing interest in buying halal food. On the other hand, Islamic brands do not affect the buying interest of Generation Z Muslims in halal products. This shows that Islamic brands in the food sector have no impact on Generation Z Muslims in a Muslim-majority country like Indonesia. This also confirms previous studies conducted in Muslim-majority countries such as Saudi Arabia that Islamic brands do not increase interest in buying halal food. This is because they are used to buying food without seeing the Islamic brand as long as it is halal. However, this result may be different if Muslims live in a non-Islamic country since Islamic branding can provide a comfortable feeling for Muslims in a non-Islamic country.
Historical information in the modern Russian press: Languages of representation
Authors:   St. Petersburg State University, Voskresenskaya Marina A.
Published: January 2023

The article examines the languages of media representation of history, which are understood as approaches to the presentation of historical information found in the modern Russian periodical press. An original classification of such approaches is proposed, including scientific, quasi-scientific, extra-scientific, pseudoscientific languages of representation. Each of them, as a set of means of expressing thought and its design in the media text, is subjected to a comprehensive analysis using linguistic, typological, intentional, comparative, contextual components in order to assess the degree of their reliance on a scientific and historical basis. The need for such an analysis is caused by the fact that the media discourse of history is not limited to the popularization of scientific historical knowledge, but the criterion for the reliability of historical information transmitted through the media is its scientific validity, regardless of the external form of representation. The objectives of the study were not to clarify the ideological positions or historiographical versions presented in the analyzed texts. The work focuses on the media presentation of historical information, primarily on the author’s intentions, style of presentation and the nature of argumentation in the comprehension and explanation of data. The material for the study was selected publications on the topic of history from the current Russian periodical press (February — April 2022). The dependence of the characteristics of the language of representation on the type of publication, the professional status of the author of the publication, the motives of his appeal to history and a number of other factors is shown. It is concluded that in practice a single approach in its full-scale format is rarely used. As a rule, in the media text it is possible to identify elements of various languages of the representation of history in various combinations with the dominance of the general journalistic style of presentation.
The media language as an object of journalism science: To the history of the formation of St Petersburg media linguistics scientific school
Authors:   St. Petersburg State University, Khubetcova Zalina F.
Published: January 2023

The article is devoted to the history of Soviet journalism science and the isolation of the mass media language research industry in it. The purpose of the study is to identify the national and cultural specificity of the Russian science of journalism and to popularize its achievements. Based on a comparative analysis of the European, American and Soviet models of the journalism science, it was proved that the important factors in the development of global science was the exchange of research practices both between scientists from different countries and between generations of researchers within the same state. The importance of the personal factor in determining the professional ideology of the science of journalism and its disciplinary structure was established. When addressing of the disciplinary affiliation of media linguistics as a theoretical and methodological basis for speech phenomena of mass communication studying, it was noted that the attribution of media language research to the subject field of journalism theory can be considered the specifics of the national model of science on journalism. Using the example of the history of the development of the Leningrad Scientific and Educational School of Journalism, it was shown that the reproduction of research personnel of narrow media linguistic specialization took place at Leningrad University with specialists with classical philological education. Unique practices of studying media texts in Department of Stylistics and Editing of the Faculty of Journalism of Leningrad State University have developed, as a result of the implementation of an experiment at the university to develop methods for teaching and studying the language of the specialty.
Communicative behavior of a professional language personality of a doctor in a media discourse (based on the material of television programs about health)
Authors:   Tomsk Polytechnic University, Volkova Evgeniya V.
Published: January 2023

The paper is devoted to the study of the specifics of the communicative behavior of a doctor’s professional linguistic personality in the media discourse. The relevance of the work is determined by the need for a systematic linguistic study of professional communication in new media-discursive conditions, as well as insufficient knowledge of the implementation of the professional linguistic personality of a doctor in the aspect of mediatization of medical discourse. The object of the study is the professional communication of a doctor in the media discourse. The subject of the study is the contexts of a medical TV program, representing the communicative behavior of a doctor’s PNL. The purpose of the study is to identify the discursive specifics of the communicative behavior of the professional language personality of a doctor in a television program about health. The research methodology was discourse analysis, on the basis of which the parameters for describing the doctor’s communicative behavior in the media discourse were determined. The features of doctor’s media communication in telediscourse are revealed taking into account the goals of professional activity and within the framework of the status-role culture of the profession, the processes of transformation of strategic planning of doctor’s communication are analyzed, the hierarchy of the communicative goals of a medical worker in television programs about health is determined. The discursive specificity of the doctor’s communicative behavior in television discourse is characterized. It has been established that the professional linguistic personality of a doctor in the media discourse is a special type of professional linguistic personality that functions in the media environment and is formed by a complex of social and communicative roles of a representative of the medical community and status in the media space.
Geography of Russia's exports in the new sanctions realities
Authors: Sycheva K. G.
Published: January 2023

The article examines the current trends in the development of Russia's foreign trade relations, namely the formation of new vectors of cooperation on the international market against the background of anti-Russian sanctions policy, as well as under the influence of the COVID-19 pandemic and the processes of digital transformation of the world economy and trade. The author concludes that at the present stage, the Russian economy is in a state of uncertainty associated with strong geopolitical tensions, the coronavirus pandemic, disruptions in global supply chains and other negative external and internal factors. The purpose of the study is to develop proposals to support Russian producers in the interests of expanding the geography of exports to friendly countries, as well as protecting the national economy from the impact of risks. As the analysis showed, in the conditions of actual transformation processes among Russia's trading partners, interaction with countries such as China and Turkey has the greatest potential, given their interest in cooperation and refusal to impose anti-Russian sanctions. In addition, Turkey is an important transit hub for Russian imports. The article concludes that the prospects for promoting and increasing the volume of Russian exports are largely associated with China and Turkey. Within the framework of this study, a set of measures to support domestic producers to expand the geography of Russian exports towards other countries has been formulated.
International practice of developing the marketing of territories
Authors: Shishkin A. V. , Mileshina A. A. , Azaryan E. M. , Voziyanov D. E.
Published: January 2023

The article analyzes international examples of the development of the image of territories and the creation of a city brand, gives marketing recommendations for the development of large and small settlements. Territories need marketing in order for management entities to achieve their goals at various levels. To do this, it is necessary to form a conceptual approach to the marketing of territories. Currently, modern countries, regions and cities need not only to offer a product demanded by the consumer (in our case, territories), but also to attract the attention of their target audience. It is difficult to overestimate the role of territory marketing in today's rapidly changing world. Territorial branding contributes to success in all areas of activity, both large and small settlements. These tools help them develop and give impetus to social change. These tools help to find development opportunities and even give them.
The influence of sanctions on the transformation of trade cooperation of countries within the world economy
Authors: Novikova E. S.
Published: January 2023

The article analyzes the positions of the world's leading economies in global value chains since the 60s of the XX century. The features of the formation of modern key centers of production chains, including China, the USA and Germany, are reflected. The analysis of the share of participation of ten leading economies of the world and Russia in global value chains, including in such sectors of the economy as agro-industrial, industrial, construction, services and mining, was carried out. It was revealed that in all the sectors of the economy considered, China managed to reach the first positions, with the exception of the mining sector, where the leading positions remain for the United States, followed by Russia. It is established that the decline in the share of developed economies in global value chains has led to the introduction of sanctions against those countries whose economic opportunities and prospects have served as a threat to the sustainable development of the former, primarily against China and Russia. The analysis of the transformation of Russia's trade relations with key partners has been carried out since 2013, when the dependence of the Russian economy on imports was maximum and at the same time the Western bloc of countries imposed the first sanctions against our country. Possible prospects for further development of both the Russian economy and other countries playing a key role in the future formation of the entire world economy are presented.
Effects of international nuclear power plants construction projects on sustainable economic development of emerging economies
Authors: Mazurova E. K. , Guseva E. S.
Published: January 2023

The solution to the problem of the global energy transition requires re-consideration of the role of nuclear energy in the energy mix of the future. The importance of nuclear energy in the global energy complex seems to increase across the world, especially due to the rising prices for fossil energy resources. A number of developing countries around the world are considering programs for the construction of nuclear power plants of large or small capacity, offered by foreign partners. This trend emphasizes the relevance of analyzing the economic effects of the development of nuclear energy in developing countries that are already successfully using nuclear energy technologies to assess the prospects for international trade in nuclear energy technologies. The article discusses the contribution of nuclear energy to the economic growth of developing countries based on the analysis of the direct and indirect economic effects of the development of nuclear energy in developing countries. The article identifies the areas of this impact and determines the main problems and features of the introduction of nuclear energy into the energy complex of a developing country. The paper concludes on the significant impact of nuclear energy on the socio-economic development of the country and the important role of developing countries in determining the positions of nuclear energy in the energy complex of the green world economy.
Rubtsovo-Semey cluster of Russian-Kazakh economic cooperation in China's strategic initiative "One Belt One Road"
Authors: Krasnoyarova B. A. , Krotov A. V. , Tabakaeva E. M.
Published: January 2023

The article is devoted to the search for opportunities for reindustrialization of depressed border ultracontinental territories in the context of the implementation of China's strategic initiative "One Belt One Road". The purpose of the study is to find ways to restore and develop economic ties between two border regions – the Altai Territory in the Russian Federation and East Kazakhstan, as the hypothesis of the study is the possibility of increasing the effectiveness of their joint activities. The object of research in the article is the cross-border area between Rubtsovsk and Semey and their adjacent territories. On the basis of a system-dialectical approach, the possibilities of creating a Rubtsovo-Semey industrial and innovative hub within the Altai Territory and the East Kazakhstan region are analyzed. The authors conclude that such cooperation can open up new opportunities for industries producing resource-intensive consumer goods, given the traditional ties and proximity of cultures of the population living here. The article defines the specialization of territories and the existing level of interaction between regions. The authors substantiate the sectors of the economy that are promising for development in the cluster. The role of Turksib for the reindustrialization of depressed cross-border territories is shown. A concept for the development of a future cross-border industrial cluster is proposed, which is one of the scientific results of the study.
Labelling Matrix Metalloproteinases
Authors: Zhang Run-Fu , Zhang Bing , Chang-Jiang Wang , Jin Jing-Yi
Published: January 2023

Matrix metalloproteinases (MMPs) are a family of zinc-containing proteases
that participate in many physiological and pathological processes in vivo. Recently, the
MMP network has been established according to a deeper understanding of its functions.
Some MMPs have been also regarded as biomarkers of various diseases, including inflammation,
nerve diseases, and cancers. MMP labelling has been thus paid more attention
in recent decades. Accordingly, both reagents and technologies for MMP labelling
have been rapidly developed. Here we summarize the recent development of some MMP
labelling methods. This review was identified through keyword (MMPs; labelling; etc.)
searches in the ScienceDirect database, Scifinder, Web of Science, and PubMed for
which typical cases were used for an inductive overview. In spite of the advances in
MMP labelling, selective labelling of a specific MMP is still an open issue. We hope that
this article can be helpful in developing specific MMP labelling methods in future.
Age-Related Alterations in Mesenchymal Stem Cell Function: Understanding
Mechanisms and Seeking Opportunities to Bypass the Cellular Aging
Authors: Rasouli Mehdi , Naeimzadeh Yasaman , Hashemi Nader , Hosseinzadeh Simzar
Published: January 2023

Undoubtedly, mesenchymal stem cells (MSCs) are the most common cell therapy candidates in
clinical research and therapy. They not only exert considerable therapeutic effects to alleviate inflammation
and promote regeneration, but also show low-immunogenicity properties, which ensure their safety
following allogeneic transplantation. Thanks to the necessity of providing a sufficient number of MSCs to
achieve clinically efficient outcomes, prolonged in vitro cultivation is indisputable. However, either following
long-term in vitro expansion or aging in elderly individuals, MSCs face cellular senescence. Senescent
MSCs undergo an impairment in their function and therapeutic capacities and secrete degenerative
factors which negatively affect young MSCs. To this end, designing novel investigations to further
elucidate cellular senescence and to pave the way toward finding new strategies to reverse senescence is
highly demanded. In this review, we will concisely discuss current progress on the detailed mechanisms
of MSC senescence and various inflicted changes following aging in MSC. We will also shed light on the
examined strategies underlying monitoring and reversing senescence in MSCs to bypass the comprised
therapeutic efficacy of the senescent MSCs.
The Impact of COVID-19 Lockdown on Patients with Type 2 Diabetes
Mellitus: A Brief Report
Authors: Vozza Alfredo , Porfido Erasmo , Delvino Alessandra , Custodero Carlo , Lisco Giuseppe , Triggiani Vincenzo , Tortorella Cosimo , Piazzolla Giuseppina
Published: January 2023

Background:

The Italian population’s habits changed dramatically during the “COVID-
19 lockdown” due to physical distancing and self-isolation. Moreover, medical consultations of
patients with chronic diseases, such as type 2 diabetes (T2D), were suspended or postponed, unless
urgent or semi-urgent, for several consecutive months. Thus, it is expected that the lockdown could
have affected glucometabolic control in T2D.

Purpose:

The aim of the study was to assess changes in glucometabolic control in a cohort of T2D
patients before (T1) and after (T2) the COVID-19 lockdown (March-May 2020).

Methods:

The study was approved by the Ethics Committee of the University of Bari, and all patients
provided informed written consent to participate. Medical history, complete physical examination,
and laboratory assessment were conducted as real-life clinical practice. Changes in clinical
and laboratory variables between T1 and T2 were calculated.

Results:

In detail, 13 patients were on metformin as monotherapy, 36 on GLP-1RA, 12 on sodiumglucose
transporter 2 inhibitors (SGLT-2i), and 2 on dipeptidyl-peptidase 4 inhibitors (DPP4i). The
mean age was 65.3 years (43-83). Study participants were mainly men (73%). The body weight
(BW) ranged from 56 to 145 kg, and the waist circumference ranged from 88 to 146 cm. The mean
HbA1c was 51.0 mmol/mol. At T2, no statistically significant changes were observed from baseline
except for BW [-1.6 (-2.60 to -0.62)] and HbA1c [-2.90 (-4.69; -1.12)].

Conclusion:

We evaluated the effects of the COVID-19 lockdown on glucometabolic control in
patients with background well-controlled T2D. We found that the lockdown had no adverse effects
on metabolic profile regardless of background clinical characteristics and antihyperglycemic management.
Despite limitations due to the nature of this study (sample size, retrospective observation,
lack of data on lifestyle changes in our patients' everyday lives), T2D patients managed in our
Diabetes Centers faced the lockdown-related restrictions without any detrimental consequence.
Assessing the Structure of Tear Ferning in a Group of Healthy Young Subjects: A Pilot Study
Authors: Almutleb Essam Saad
Published: January 2023

Purpose:

The purpose of the current pilot study is to investigate the structure of tear ferning in female and male subjects of different ages.

Methods:

A total of six normal subjects participated in the current pilot cross-sectional study. The female subjects were 11, 28, and 42 years old, whereas the male subjects were 28, 32, and 34 years old. Five tear samples were collected from each subject using capillary tubes. A small drop (1 μl) of tears was dried on a glass slide and observed under a light microscope (Olympus BX1). Rolando (four grades) and Masmali (five grades) scales were used to classify the tear ferning patterns.

Results:

The tear film pattern of all the subjects was surrounded by three thick and homogenous peripheral layers. The layers surrounding the ferning were better distinguished in the 11-year-old female compared to the layers around the ferning in other subjects. The tear ferning of the 11-year-old female was very fine without any spacing and considered as a Grade 0 (Masmali), Type 1 (Roland), whereas the 28-year-old female had Grade 3 (Masmali), Type 4 (Rolando). The 28-year-old male had Grade 1 (Masmali), Type 2 (Rolando), whereas the 34-year-old male and 42-year-old male had ferning of Grade 3 (Masmali), Type 4 (Rolando).

Conclusion:

The current pilot study showed that irrespective of gender, ferning patterning and grading degenerated and increased, respectively, as the age of the participants increased. Furthermore, the grading of ferning was better in male participants compared to female participants.
Phytochemical Investigation of Hypericum heterophyllum Flowers:
LC-ESI-MS/MS Analysis, Total Phenolic and Flavonoid Contents,
Antioxidant Activity
Authors: Erenler Ramazan , Yaman Cennet , Demirtas lbrahim , Hakki Alma Mehmet
Published: January 2023

Background:

Hypericum heterophyllum has been used as a traditional medicine and includes
significant bioactive compounds.

Objective:

To quantitatively determine the phenolic and flavonoid contents of Hypericum heterophyllum
flowers and evaluate the antioxidant activity. Also, to present the activity-compound relationship.

Methods:

Flowers of H. heterophyllum Vent., endemic species for Turkey were collected from
Yozgat-Turkey. H. heterophyllum flowers were extracted with methanol, ethanol, acetone, and chloroform
individually. LC-ESI-MS/MS analysis for phytochemicals was carried out for each extract.
Total phenolic and flavonoid content were carried out for each extract. The antioxidant activity was
performed using DPPH•, ABTS•+, hydroxyl radical, and superoxide radical scavenging assays.

Results:

Chlorogenic acid was found as a major compound in all extracts. Among the extracts,
methanol extract included the most phenolic compound. The methanol extract and acetone extract
consisted of the most flavonoids. Acetone and ethanol extracts revealed the most DPPH and ABTS
activity respectively. Acetone extract exhibited the highest hydroxyl radical and superoxide radical
scavenging effect

Conclusion:

Flowers of H. heterophyllum contain bioactive compounds and they revealed good
antioxidant activity. Hence, H. heterophyllum flowers could be a promising agent for the pharmaceutical
and food industries.
Перколяционный транспорт заряда по электризованной поверхности политетрафторэтилена
Authors: Кузьмин Ю.И.
Published: January 2023

Изучен транспорт заряда по поверхности электризованных пленок политетрафторэтилена при адсорбции электропроводящей фазы. Обнаружено затухание скорости перемещения перепада потенциала по поверхности пленки, ограничивающее область его распространения. Сделана оценка критического показателя корреляционной длины перколяционного кластера, образующегося на электризованной поверхности политетрафторэтилена при повышенной влажности. Экспериментально установлено, что разряд электризованной поверхности обусловлен перколяционными процессами. Ключевые слова: перколяция, порог протекания, адсорбция, электризация.
Влияние температуры роста на физико-химические свойства слоев низкотемпературного GaAs, созданных методом импульсного лазерного напыления
Authors: Крюков Р.Н. , Данилов Ю.А. , Лесников В.П. , Вихрова О.В. , Зубков С.Ю.
Published: January 2023

Low-temperature device-quality GaAs layers with high resistivity were obtained by pulsed laser deposition. The properties of GaAs layers are sensitive to the process temperature. At a growth temperature of less than 300°C, the layers have low electron mobility and a shift of the GaAs stoichiometry towards the region of arsenic enrichment at a level of 1–2 at.%. At a growth temperature of more than 300° C., the layers show an improved crystalline quality. The dependence of the relative intensity of the As 3d photoelectron line on the growth temperature confirms this trend with a change in the growth temperature.
Гибридный концентраторно-планарный фотоэлектрический модуль с гетероструктурными солнечными элементами
Authors: Шварц М.З. , Андреева А.В. , Андроников Д.А. , Емцев К.В. , Ларионов В.Р. , Нахимович М.В. , Покровский П.В. , Садчиков Н.А. , Яковлев С.А. , Малевский Д.А.
Published: January 2023

The paper presents a promising solution for photovoltaic modules that provides overcoming the main conceptual limitation for the concentrator concept in photovoltaics - the impossibility to convert diffused (scattered) solar radiation coming to the panel of sunlight concentrators. The design of a hybrid concentrator-planar photovoltaic module based on heterostructure solar cells: A3B5 triple-junction and Si-HJT is presented. The results of initial outdoor studies of the module output characteristics are discussed and estimates of its energy efficiency are given.
Особенности проводимости композитов нановолокон ZnO и NiO
Authors: Мартышов М.Н. , Смирнова В.В. , Ильин А.С. , Платонов В.Б. , Форш П.А. , Кашкаров П.К.
Published: January 2023

In this work, composites of ZnO and NiO nanofibers with n- and p-type conductivity, respectively, were studied. It is shown that the conductivity of the studied composites strongly depends on the arrangement of ZnO and NiO nanofibers. In the case of a mixture of ZnO and NiO nanofibers (with their random arrangement relative to each other and electrical contacts), conduction can occur only along ZnO fibers, which have a higher conductivity compared to NiO. However, the presence of the ZnO/NiO p-n heterojunction leads to the formation of depleted regions in ZnO, as a result, the conductivity of the mixture becomes several orders of magnitude lower than the conductivity of ZnO nanofibers. In the case of a two-layer composite, in which one layer consists of NiO nanofibers and the other layer consists of ZnO nanofibers, charge carriers move through the p-n NiO/ZnO heterojunction, which leads to a rectifying current-voltage characteristic and opens up broad prospects for the use of such systems in electronic devices.
Necesidades Operativas de Fondos: Diagnóstico de las terminales portuarias ecuatorianas
Authors: Vélez Bermello Luisa María , Flores Sánchez Gustavo Geovanni
Published: January 2023

El propósito de esta investigación consiste en diagnosticar la situación financiera operativa de las terminales portuarias del Ecuador durante el período 2015 – 2019, mediante el análisis de sus Necesidades Operativas de Fondos frente a la relación que muestran con el Fondo de Maniobra, rentabilidad y endeudamiento; establecidas como variables independientes. Se aplicó una metodología descriptiva correlacional para datos cuantitativos, constituidos por seis terminales portuarias pertenecientes a la Asociación de Terminales Portuarios Privados del Ecuador y a la Cámara Marítima del Ecuador. El presente estudio devela promedios de Necesidades Operativas de Fondos y Fondo de Maniobra negativos; situación que produce una financiación espontánea debido a una situación de iliquidez y preponderancia del financiamiento con proveedores, pero que demuestra una relación positiva con los niveles de rentabilidad. Sin embargo, al existir financiación espontánea suficiente, se evidencia un elevado porcentaje de endeudamiento en el largo plazo. Dichos resultados se traducen en oportunidades de fortalecimiento en las inversiones del sector portuario ecuatoriano.