bluuebunny/crossref_metadata_2025 huggingface dataset:
The Subtlety of Hegemonic Masculinity in Nepali Films through Digital Platforms: A Critique of the Film Saino
Authors: Sherma Amar Bahadur
Published: February 2025

In the paper, I argue that Nepali films are still promoting the ideology of hegemonic masculinity and patriarchy implicitly through reels in the name of upholding cultural norms. Since the internet is becoming more accessible and cheaper than before, more Nepali people of all ages tend to see Nepali films conveniently on different digital platforms. For the past decade, Nepali films have been incorporating ethnic cultural contents into their productions to both promote it and serve their audiences a new flavor. However, the effect some cultural values can have on audiences cannot be overlooked. To delve into the impact of Nepali films on audiences, I undertook a case study of the Nepali film Saino and analyzed the film’s content, and other relevant sources, applying Connell’s theory of hegemonic masculinity and other feminist ideologies. The study demonstrated that Nepali films are more concentrated on their commercial gains rather than its social and psychological impact on audiences, especially young ones.  Therefore, I urge censor boards, scriptwriters, directors, producers, and audiences to critically analyze the messaging of entertainment media and engage actively in a process of deepening understanding of invisible gender dynamics so that a fairer, more inclusive and healthier society can be fostered. Overall, this paper contributes to the people’s understanding of how hegemonic masculinity and cultural values are being simultaneously perpetuated in the absence of consistent censorship.
Efektivitas Pelayanan APM pada Pelayanan Rawat Jalan RSUD Gambiran Kota Kediri
Authors: Cahyani Alicya Mei , Purnamasari Ayu Tyas , Sunindya Bernadus Rudy
Published: February 2025

Rumah sakit adalah institusi pelayanan kesehatan yang menyelenggarakan pelayanan kesehatan perorangan secara paripurna yang menyediakan pelayanan rawat inap, rawat jalan dan rawat darurat. Salah satu teknologi yang berkembang saat ini dilingkungan Kesehatan dalam mempermudah proses layanan pendaftaran pasien yaitu Anjungan Pendaftaran Mandiri (APM). Penelitian ini bertujuan untuk mengetahui efektivitas pelayanan Anjungan Pendaftaran Mandiri (APM) pada pelayanan rawat jalan RSUD Gambiran Kota Kediri. Jenis penelitian ini menggunakan metode penelitian deskriptif dengan pendekatan kuantitatif. Sampel dalam penelitian ini adalah pasien rawat jalan yang menggunakan layanan APM (Anjungan Pendaftaran Mandiri) dan TPPRJ (Tempat Pendaftaran Pasien Rawat Jalan) di RSUD Gambiran Kota Kediri. Pengumpulan data menggunakan metode observasi dengan instrument penelitian berupa table hasil observasi. Hasil penelitian dari 30 responden pada masing – masing layanan rumah sakit berdasarkan rata – rata pada perbedaan lama waktu pasien saat menggunakan layanan APM yaitu 00.04 menit, sedangkan pada layanan TPPRJ yaitu 00.37 menit. Dapat disimpulkan bahwa layanan Anjungan Pendaftaran Mandiri lebih efisiensi dibandingkan dengan layanan TPPRJ (Tempat Pendaftaran Pasien Rawat Jalan). Kesimpulannya diharapkan pegawai rumah sakit melakukan sosialisasi berupa arahan prosedur atau alaur kepada pasien untuk menggunakan layanan mesin APM (Anjungan Pendaftaran Mandiri).
Hubungan Indeks Massa Tubuh Dengan Kejadian Dismenore Pada Remaja Putri Di Pondok Pesantren Nurul Islam Jember
Authors: Karomah Ilmiyatul , Maryanti Syiska Atik , Bachri Syaiful
Published: February 2025

Background: BMI associated with the presence of fat can increase prostaglandins which cause dysmenorrhea. Dysmenorrhea is a problem that can arise due to high fat which can  increase prostaglandins, causing pain. Dysmenorrhea  can  interfere  with  daily  activities,  especially  decreased  learning  productivity  which  results  in
decreased achievement. Dysmenorrhea is included in the risk group  so reducing dysmenorrhea is considered important. Purpose: Analyzing the relationship between Body Mass Index and the incidence of dysmenorrhea in young women at the Nurul Islam Islamic Boarding School, Jember. Methods: This study used an observational method with a cross sectional approach. The population of all class X teenage girls is in the Nurul Islam Jember Islamic Boarding School. The sample size was 74 young women who were taken by simple random sampling, by distributing questionnaires and then measuring height and weight. Results: This study shows that most of the young women at the Jember Nurul Islam Islamic Boarding School have an abnormal BMI of 66.21% and 54.1% of them experience  dysmenorrhea.  Statistical  test  results  show  a  relationship  between  BMI  and  the  incidence  of dysmenorrhea in young women at the Nurul Islam Jember Islamic Boarding School. Conclusion: In this study, if the BMI was underweight, overweight and obese, the dysmenorrhea score would be high, conversely if the BMI was normal, the dysmenorrhea score would decrease. It is hoped that for health services, it is hoped that it can improve the performance of UKS staff in preventive promotive efforts regarding the incidence of dysmenorrhea in young women such as providing information in the health unit which contains nutrition intake.
Hubungan Lama Penggunaan Kontrasepsi Pil Kombinasi Dengan Kejadian Hipertensi Di Wilayah Puskesmas Sumbersari Kabupaten Jember
Authors: Elvina Hilda Yuni , Kiswati Kiswati , Restanty Dian Aby
Published: February 2025

Hormonal disruptions brought on by long-term usage of combined pill contraceptives can have an effect on blood pressure. Serious consequences can arise from untreated hypertension, also known as high blood pressure. According to the 2018 Riskesdas, hypertension affected 51.17 percent of women and 48.83 percent of males. With 3,934 participants, the Sumbersari Health Center had the greatest number of people who accepted combination tablet contraceptives in a preliminary trial. In the Sumbersari Health Center region of Jember Regency, researchers set out to find out how often hypertension is and how long people have been taking combination pill contraceptives. A cross-sectional design was employed in this investigation. Out of a total population of 271 women, 55 were selected using the Simple Random Sampling approach. Questionnaires, KB cards, and a Taff Omicron B869/BW3205 Digital Tensimeter with Chi-Square Test analysis were the research measuring instruments. Hypertension is not experienced by the majority of users of new category combination pill contraceptives (<2 years) (29%), and only a tiny percentage of users (16.3%) do experience hypertension. The majority of people who have used old-category combination pill contraceptives for at least two years (54.6% of the total) have hypertension, while a tiny percentage of those people (11%) do not. The correlation between the duration of using combination pill contraceptives and the occurrence of hypertension was confirmed by the chi-square test, which yielded a p-value of 0.002 <? 0.05. Most users of old category combination pill contraceptives (?2 years) experienced hypertension (54.6%). So that acceptors of combination pills are expected to replace other contraceptives if they have used combination pills for ?2 years and experience symptoms of hypertension.
Analisis Pemberian ASI Eksklusif Terhadap Kejadian Stunting Pada Balita Usia 6-24 Bulan di Desa Besuk Kecamatan Klabang Bondowoso
Authors: Nafisa Wildatin , Yulifah Rita , Susilawati Susilawati
Published: February 2025

Background: Stunting occurs when a child's length or height is far below average due to growth and development conditions caused by chronic hunger and frequent illnesses. Until 2022, the percentage of toddlers with stunted growth was 21.6% nationally, 19.2% in East Java Province, and 32.0% in Bondowoso Regency. The purpose of this study was to examine the correlation between stunting rates and the availability of exclusive breastfeeding. Method: A cross-sectional technique based on observational analytics was used in this study design. Mothers with toddlers aged 6-24 months became the study population; 40 mothers were selected using a simple random sampling procedure. Information was collected through a survey. Chi-Square test data analysis. Results: 70% of respondents did not provide exclusive breastfeeding to toddlers and the proportion of stunting incidents was 52.5%. In this study, the significance level ?-value = 0.003 <? 0.05, which means there is a relationship between exclusive breastfeeding in toddlers and the incidence of stunting. Conclusion: The correlation between exclusive breastfeeding and the prevalence of stunting is likely caused by the high calcium content in exclusive breastfeeding which is effectively absorbed by the body so that growth, especially height, can run optimally and reduce the risk of stunting.
Czy monady można badać naukowo?
Authors: Kościuszko Krzysztof
Published: February 2025

Artykuł nawiązuje do tekstu O nowym typie monadologii, opublikowanego w „Studiach z Historii Filozofii” (2018, t. 9, nr 4). Zamierzeniem autora jest kontynuowanie pewnych motywów, ale zarazem opisanie relacji nierozciagłościowego aspektu monad do ich rozciągłościowych ekspresji, jakościowości monad oraz ich powiązania z pojęciami współczesnej nauki. Ogólnie rzecz ujmując, chodzi o próbę wypracowania bardziej współczesnego modelu monadologii.
THE MEANING OF THE CONCEPT OF LOVE ACCORDING TO SHREE RAJNEESH (OSHO)
Authors: Hrehorowicz Artur
Published: February 2025

Artykuł składa się z dwóch części. Pierwsza część koncentruje się na krytyce powszechnych, lecz według Osho fałszywych pojęć miłości, które prowadzą do jej błędnego postrzegania i stanowią przeszkody w duchowym rozwoju. Druga część zgłębia istotę prawdziwej miłości w ujęciu Osho, podkreślając jej głębokie, „źródłowe” aspekty oraz znaczenie w procesie duchowego rozwoju jednostki. Poprzez tę analizę artykuł dąży do uzupełnienia luki w badaniach nad myślą Osho, oferując nową perspektywę jego nauczania o miłości
WKŁAD ŚREDNIOWIECZA W ROZWÓJ ZDROWIA PUBLICZNEGO
Authors: Nowacka Maria
Published: February 2025

Skuteczność działań zdrowia publicznego zależy w pierwszym rzędzie od poziomu medycyny i dynamiki jej rozwoju. Jednak z uwagi na odniesienie działań do zbiorowości konieczne jest, aby działania te miały charakter społeczny, rangę działań państwowych, a także posiadały duży stopień akceptacji społecznej, wyrażający się w gotowości do prowadzenia przez członków danej społeczności właściwego, tj. prozdrowotnego trybu życia. Jeśli spojrzymy na zagadnienie z punktu widzenia historii zdrowia publicznego,to zauważymy, iż warunkami koniecznymi do powstania i rozwoju tej dziedziny są: (1) utrwalenie się w skali społecznej pragnienia życia nie tylko w jak najlepszym zdrowiu, lecz także w jak najdłuższym czasie, (2) zinstytucjonalizowanie zawodu lekarskiego, (3) zinstytucjonalizowanie organizacji działań prozdrowotnych.Dopóki te trzy warunki nie zostały spełnione, medycyna odnosiła się wyłącznie do jednostek, a nie do zbiorowości.
WPŁYW CZARÓW NA CHOROBY ZWIERZĄT GOSPODARCZYCH W ŚWIETLE XVII-WIECZNEGO SKŁADU ALBO SKARBCA… JAKUBA KAZIMIERZA HAURA
Authors: Kowalczyk-Wesołowska Sabina
Published: February 2025

Dotychczasowe badania Składu albo skarbca znakomitych sekretów oekonomijej ziemiańskiej...(pierwsze wyd. 1689) Jakuba Kazimierza Haura skupione były raczej na przesądach i wierzeniach wiązanych bezpośrednio z ludźmi lub zwierzętami łownymi. W niniejszym artykule tekst Haura badany jest pod kątem opisów chorób zesłanych na zwierzęta gospodarcze przez wiedźmy.W omawianiu chorób oraz podawaniu remediów na nie przejawia się XVII-wieczna skłonność do łączenia chrześcijańskiej religijności z myśleniem magicznym. Na podstawie analizowanego dzieła odtworzone zostaną także poglądy samego Haura na temat magii, przedstawione na tle tekstów (utworów literackich, kazań czy zielników) innych autorów tego okresu.
FAUNA – FLORA – BAUDELAIRE. LIRYCZNY WYKŁAD WINCENTEGO KORAB-BRZOZOWSKIEGO O NATURZE
Authors: Borek Bartłomiej
Published: February 2025

Artykuł poświęcony faunie i florze w literackiej spuściźnie Wincentego Korab-Brzozowskiego. Szkic stanowi próbę odkodowania sensów zawartych w symbolicznych reprezentantach świata roślinnego i zwierzęcego w poezji młodopolskiego twórcy, czyniącego naturę asumptem do rozważań na tematy uniwersalne, jak życie, śmierć, grzech, cierpienie etc. Kontekstem do rozważań uczyniono myśl Charles’a Baudelaire’a.
PSYCHOLOGICZNY MECHANIZM WYPARCIA NA PRZYKŁADZIE POSTAW NAZISTOWSKICH ZBRODNIARZY WOJENNYCH
Authors: Sołga Przemysław
Published: February 2025

Psychologiczny mechanizm wyparcia był jednym z zasadniczych elementów, który indukował postawę obronną nazistowskich zbrodniarzy wojennych. Wypierali oni ze świadomości zbrodniczy charakter czynów popełnianych w czasie wojny, przyjmując także pseudoargumentację dla potwierdzenia zasadności podstawowych zrębów nazistowskiej ideologii, zwłaszcza rasizmu.Wspomniany mechanizm towarzyszył także ich zeznaniom składanym po wojnie, którymi starali się usprawiedliwić swoje postępowanie, bądź udowodnić swoją niewinność. Był on ważną komponentą psychologii nazizmu, aktywną w sposóbszczególny zwłaszcza w okresie wojny totalnej.
A REUSABLE PHTHALIMIDE-N-SULPHONIC ACID (PISA) CATALYZED SYNTHESIS OF 2,3-DIHYDROQUINAZOLINONE DERIVATIVES: AN ECO-FRIENDLY PROTOCOL
Authors: J. R. Deshmukh  , U. N. Chaudhar  , N.D. Sakhare  , A. M. Patil  , S. G. Sonkamble
Published: February 2025

We have developed a convenient and efficient strategy for the preparation of 2,3-dihydroquinazolin- 4(1H)- one derivative (DHQ) from condensation of 2-aminobenzamide and various aldehydes using phthalimide-N-sulfonic acid (PISA) as a catalyst is described. The present method has some important features such as mild reaction conditions, short reaction times, less catalyst dosage, and high yields with the green aspects by avoiding toxic catalysts and solvents.
Composition-Sensitive Analysis of the Human Genome for Regulatory	Signals
Authors: Kel-Margoulis Olga V. , Tchekmenev Dmitri , Kel Alexander E. , Goessling Ellen , Hornischer Klaus , Lewicki-Potapov Birgit , Wingender Edgar
Published: February 2025

Known transcription regulatory signals which generally act as transcription factor binding sites (TFs) differ significantly in their base composition. Therefore, their occurrence in a genome largely depends on the local base composition. In an attempt to initiate an all human genome analysis for the occurrence of potential TFs, we systematically analyzed the GC-content of distinct functional regions (e.g., upstream and downstream gene regions, exons, long and short introns, repetitive elements) and correlated the frequencies of potential binding sites of a representative set of TFs in these regions. For these analyses, we used the pattern collection of the TRANSFAC® database on transcriptional regulation, the information about functionally relevant combinations of them from the database TRANSCompel®, and our new resource, TRANSGenome™, which provides an overall annotation of the human genome with emphasis on its regulatory characteristics. We show that the occurrence of sequence patterns with regulatory potential may be supported by, but cannot be fully explained by either the GC content of a whole chromosome or its putative promoter regions, nor by the information content of the patterns. Several patterns, HNF-3, NFAT, and GC box, show a clear overrepresentation in all promoter groups as well as in all chromosomes. Other patterns, like E2F and CRE-BP1, are underrepresented in all promoter groups as well as in all chromosomes in comparison with random sequences. Simultaneously, both patterns are over-represented in promoters in comparison with repetitive elements. We define several structural characteristics of the proximal promoters that differentiate them from other functional genomic regions. Two well-known promoter elements, GC- and TATA-boxes, are statistically enriched in promoters in comparison with random sequences, repetitive elements and exons.

Altogether, our findings provide insights into the macroheterogeneity amongst the individual chromosomes, into the microheterogeneity among different functional regions of individual chromosomes, contribute to further understanding of structural organization of gene regulatory regions, and give first hints on the development of regulatory features during evolution.
The Channel in Transporters is Formed by Residues That Are Rare in	Transmembrane Helices
Authors: Kalinina Olga V. , Makeev Vsevolod J. , Sutormin Roman A. , Gelfand Mikhail S. , Rakhmaninova Aleksandra B.
Published: February 2025

Transmembrane transport is an essential component of the cell life. Many genes encoding known or putative transport proteins are found in bacterial genomes. In most cases their substrate specificity is not experimentally determined and only approximately predicted by comparative genomic analysis. Even less is known about the 3D structure of transporters. Nevertheless, the published experimental data demonstrate that channel-forming residues determine the substrate specificity of secondary transporters and analysis of these residues would provide better understanding of the transport mechanism.

We developed a simple computational method for identification of channel-forming residues in transporter sequences. It is based on the analysis of amino acids frequencies in bacterial secondary transporters. We applied this method to a variety of transmembrane proteins with resolved 3D structure. The predictions are in sufficiently good agreement with the real protein structure.
iUDB: An Object-Oriented System for Modelling, Integration and	Analysis of Gene Controlled Metabolic Networks
Authors: Freier Andreas , Hofestädt Ralf , Lange Matthias
Published: February 2025

The long-term objective of our work is the computational construction of complex cellular systems. Therefore, input data must be prepared systematically first. In the field of biological data information is spread out over hundreds of molecular databases. Different approaches of data integration have been already applied in the past to provide a homogeneous access to these databases. Actually, a system is required to store integrated data of different type locally and to search for networks found in the integrated dataset. Finally, the analysis of these networks can answer different questions, e.g. the role of biochemical substances in regulatory systems or the reasoning of metabolic diseases.

In this article a novel object-oriented modelling approach in the field of biochemical networks is presented. Molecular objects are modelled conceptually using object classes, internally based on the object model OMG IDL. Specific object services are implemented automatically for each model and object instances are built using data integration. In combination with that, a specific view concept based on access paths has been implemented to model biochemical reaction rules automatically. Together with the application of graphical methods, pathways and cliques are computed by the system. They provide the topology of cellular process networks. The system has been implemented using Java and CORBA.
Restoration of vision II: Residual functions and training-induced	visual field enlargement in brain-damaged patients
Authors: Kasten Erich , Poggel Dorothe A. , Müller-Oehring Eva , Gothe Janna , Schulte Tilman , Sabel Bernard A.
Published: February 2025

Purpose: Brain damage is often accompanied by visual field defects which have been considered to be non-treatable. In recent years, however, new diagnostice methods have revealed hitherto unknown residual vision, which was found, for instance, in transition zones near the blind visual field sectors and in spared islands of vision within the blind regions ("blindsight"). Furthermore, animal studies revealed a high degree of plasticity in the visual system suggesting the possibility that recovery of vision may be induced by systematic visual training. Methods: Here we summarize a series of studies with patients suffering from visual field defects after brain lesion using some most recently developed computer-based programs for the diagnosis and treatment of visual field defects. Specifically, high-resolution perimetry (HRP) was applied to first diagnose residual function in or near the "blind" sector of the visual field. Thereafter, visual restitution training (VRT, see Kasten et al., Nature med. 4, 1998, p. 1083) was used daily for 6 months to provide systematic stimulation of these areas of residual vision. Results: In a number of studies, we have observed not only residual visual functions within or near the field defect, but we were also able to follow the course of spontaneous recovery of visual functions within weeks or months after visual system damage. Furthermore, even long after spontancous recovery is complete, computer-based visual restitution training (VRT) in or near the areas of residual vision results in a significant enlargement of intact areas, both after optic nerve damage and postchiasmatic lesions. Using VRT, we found a border shift of about 5 degrees of visual angle which cannot be explained by eye movements or eccentric fixation. We observed a transfer of this training effects to other tasks such as form and color detection, as well as to tests of visual exploration which were not specifically trained. Moreover, 72 % of the patients reported subjective improvements of vision. Training-induced visual field enlargement persisted for at least one year, even in the absence of training beyond 6 months of treatment. Conclusions: The visual system possesses a remarkable plasticity which becomes apparent in visual field enlargement during spontaneous recovery and specifie visual training. Animal studies indicate that a minimum number of residual neurons surviving the lesion, in the order of 10%, provides a sufficient substrate for recovery of vision. Though the precise mechanisms of training-induced visual field enlargement need to be further explored, VRT can be introduced for routine clinical treatment of patients with visual field defects.
ON THE FEASIBILITY OF USING MODULAR SAFETY ISLANDS AS A TRAFFIC SAFETY TOOL
Authors: Osypov Valentyn
Published: February 2025

The issue of using safety islands as an additional tool for influencing the level of accidents involving pedestrians has studied. A new type of modern security island - a modular island - is proposed, and the calculation of the maximum strength of the anchor fasteners of the arrangement is proposed. The proven fact is the effectiveness of the use of so-called "safety islands" on roads - an engineering device that allows pedestrians to safely cross the too wide carriageway of roads and technically narrow the traffic lane. Ensuring a high degree of protection of pedestrians stopped at the safety island from being by a vehicle remains an urgent issue. The search for a mathematical expression of the dependence of the holding capacity of the elements of the safety island on the strength factor of the material and the dimensions of the parts used is of interest from both a theoretical and a practical point of view. The presence of such a dependence would make it quite simple to determine the effect of changes in the cross-section of the fastening elements on the value of the energy intensity of the structures. Ensuring a high degree of protection of pedestrians stopped at the safety island from hit by vehicles remains an urgent issue. The search for a mathematical expression of the dependence of the holding capacity of the elements of the safety island on the strength factor of the material and the dimensions of the parts used is of interest from both a theoretical and a practical point of view. The main task in the search for mathematical dependencies was the modernization of already known structures and the determination of their maximum capabilities without changing the kinematics of the structure when interacting with road transport. In order to determine the possibility of increasing the holding capacity of the safety island fastening elements based on, it is necessary to consider different stages of the construction when cars hit them. The method of calculation proved that modular safety islands have a number of advantages compared to traditional ones, which will be fair if the necessary deterrent ability and strength factor of the material of the fastening elements ensured.
NATURAL TECHNOLOGIES OF PROVISION AND IMPROVEMENT INDOOR MICROCLIMATE PARAMETERS HEALTH CARE INSTITUTIONS
Authors: Predun Kostiantyn , Moisin Anatolii
Published: February 2025

One of the main goals of the concept of sustainable development is to ensure a healthy lifestyle and well-being for everyone at any age. As a result of the implementation of the set tasks, the number of deaths and illnesses as a result of exposure to hazardous chemicals, pollution and poisoning of the environment should be significantly reduced by 2030. Engineering support systems create and maintain standardized values of air environment parameters in the premises of buildings and structures of various purposes. At present, in Ukraine, state standards are adapted to European requirements for indoor microclimate and technological solutions for its organization and provision. Currently, the most effective way of bacterial disinfection of indoor air is the use of ultraviolet light. The main disadvantage of this method of air purification from pathogenic microorganisms and viruses is the harmful effect on human health of possible excess radiation, excessive concentrations of ozone and mercury vapor - ingredients of the first class of danger, which are released during the processing. In addition, disinfection occurs exclusively in those places and areas where direct ultraviolet rays enter, and exclusively in the absence of people. To eliminate these shortcomings, an innovative technology of air purification in closed rooms is proposed, which is based on natural processes of disinfection of pathogenic microflora. The method is harmless to humans and pets. Design solutions of haloaerators - devices for air disinfection in closed rooms and the technology itself - have been developed and successfully tested. According to the results of the tests, their effectiveness was confirmed - the level of bacterial air pollution in a closed room decreased from the initial value of 1500 in 40 minutes of operation of the device to 10 CFU/m3.
APPLICATION OF SATELLITE TECHNOLOGIES IN CADASTRAL WORK: INCREASING ACCURACY AND EFFICIENCY
Authors: Braslavska Oksana , Rozhi Inna , Grytsyk Oleg
Published: February 2025

Satellite technologies have great potential in cadastral works, significantly increasing the efficiency and accuracy of processes. The article examines the existing aspects of satellite monitoring for cadastral works and analyzes the issue of monitoring in the cadastre automation system related to the processing of information on cadastre objects. The basics of modern GIS technologies in conducting GPS satellite monitoring in the cadastre are described. Innovative programs for conducting satellite monitoring by other countries are considered. Which is especially relevant at the moment during military operations with the Russian Federation. Rapid monitoring using satellite technology will help increase the accuracy of reconnaissance and, accordingly, the effectiveness of artillery. The article analyzes the development of geodetic support during the performance of cadastral works, describes the use of the latest geodetic technologies - three-dimensional satellite scanning. The analysis of literary sources showed that there is a significant number of scientific works using satellite technologies for obtaining cadastral data and creating a three-dimensional cadastre. In which are described the methods of cadastral surveying, criteria for choosing measuring instruments, methods for assessing the accuracy of coordinates, algorithms for processing scanning data. However, the issue of further use of satellite technologies for cadastral documentation requires more detailed research.
ANALYSIS OF THE DEVELOPMENT OF LIDAR TECHNOLOGIES AND THE PROSPECTS OF THEIR USE DURING THE PERFORMANCE OF THE TASKS OF GEOSPATIAL SUPPORT OF ARMIES (FORCES) IN COMBAT CONDITIONS
Authors: Bulhakov Andrii , Bondar Svitlana , Demyanenko Roman , Medvedskyi Yurii , Kuzmych Oleksandr
Published: February 2025

The results of the analysis of the implementation of geospatial support of troops (forces) by military units in the performance of assigned tasks in the course of repelling the large-scale aggression of the Russian Federation against Ukraine revealed serious gaps in the provision of geospatial data to troops (forces) [1]. In particular, given the unsatisfactory state of cartographic materials, remote methods of collecting, creating (updating) geospatial data are used. The use of Earth remote sensing materials with high resolution has become a priority. LiDAR systems (3D laser scanning) are one of the varieties of Earth remote sensing technology. However, in the Armed Forces of Ukraine, this technology in the field of geospatial support of troops (forces), especially in the conditions of hostilities, is rarely used. Therefore, the use of LiDAR systems in this field is relevant and requires a thorough analysis of the current state, prospects for development and application of this technology in the mentioned direction. In this regard, this article is aimed at identifying the prospects of using LiDAR systems to increase the efficiency of the tasks of creating and updating geospatial data in combat conditions. The article presents the results of the analysis of the use of LiDAR systems, reveals the advantages and disadvantages of this technology, discovers the prospects for its development and implementation in the Armed Forces of Ukraine, substantiated practical recommendations for its use in combat conditions. The materials of the article are of practical value for officials of military administrations engaged in planning and implementation of tasks of geospatial support of the Armed Forces of Ukraine during operations, developers and users of geospatial technologies in military affairs, as well as scientists investigating the issue of task transformation in the field of geospatial support of troops (forces).
THEMATIC GEOSPATIAL DATA SETS FOR GIS MONITORING OF URBAN LAND ENGINEERING AND CONSTRUCTION CONDITIONS
Authors: Kozar Valentyn , Michno Pavlo , Galchenko Nadiya , Klyuka Olena
Published: February 2025

The lands of cities have specific features caused by the diversity of their intended use. The specifics of urban lands lead to the need to assess their condition from various aspects: socio-legal, urban planning, engineering and construction, environmental, and sanitary-hygienic. An analysis of publications devoted to the monitoring of urban lands indicates the relevance of forming datasets to evaluate the condition of the land based on these aspects, particularly from an engineering and construction perspective. Ukrainian regulations stipulate that the primary factors in the engineering and construction assessment of land are the engineering-geological conditions and the extent and development of hazardous geological processes and phenomena. Experience in urban planning shows that engineering and construction conditions can be defined as the properties and processes of the environment that influence decision-making regarding the construction and operation of structures. A generalization of approaches to the engineering and construction assessment of areas leads to the conclusion that the main criteria for this assessment are tectonic, geomorphological, engineering-geological, hydrogeological, hydrological, meteorological, and geodynamic indicators. Based on the analysis of the subject area, a class diagram of a thematic set of geospatial data for monitoring systems of the engineering and construction condition of urban lands has been proposed. The dataset includes information characterizing the suitability of the area for development. Fourteen classes were identified, reflecting the specific characteristics of the area regarding the placement of structures, their types and constructions, construction methods, and operation methods. The proposed diagram can be used in the creation of settlement monitoring systems to improve the justification of management decisions in planning area development.
Glaucocalyxin Attenuates Thyroid Cancer Cell Proliferation and Aggression Through Circ_0030018/miR-145
Authors: Sun Mingxiu , Li Jiarui , Xue Zhirui , Du Likun
Published: February 2025

Aim To disclose the effects of glaucocalyxin A (GLA) on the growth and motivity of human thyroid cancer cells and its regulation on circ_0030018/miR-145. Methods TPC1 cells were challenged with diverse doses of GLA. MTT method, colony-formation test, scratch study and Transwell test were respectively used to exploit TPC1 cell behaviors. qRT-PCR method was adopted for the detection of of circ_0030018 and miR-145 expression. Dual-luciferase reporter experiment was adopted to verify the binding between circ_0030018 and miR-145. Western blotting was applied for the detection of MMP-2 and MMP-9 expression. Results After GLA treatment, the cell proliferative inhibition rate was considerably reinforced, while the amount of cell clone formation, the number of invasive cells, the cell scratch healing rate and the expressions of MMP-2 and MMP-9 were considerably lessened. GLA treatment weakened circ_0030018 expression but strengthened miR-145 expression. Circ_0030018 could target and regulate the expression of miR-145. The si-circ_0030018 transfection repressed TPC1 cell proliferation, reduced the number of cell clone formation and the number of invaded cells, and weakened the scar healing rate and the abundance of MMP-2 and MMP-9. Circ_0030018 upregulation could overturn the effects of GLA on TPC1 cell behaviors. Conclusion GLA could inhibit thyroid cancer cell proliferative and aggressive behaviors by regulating circ_0030018/miR-145.
Anti-Inflammatory and Antiarthritic Activity of Procaine-1,3,5-Triazine Derivative for Possible Benefit in Rheumatoid Arthritis: An In Vivo Study
Authors: Tang Guangying , Wu Weiqiang , Du Pushan , Tang Zhiyu , Wang Guanlin
Published: February 2025

The present study aimed to evaluate the pharmacological effects of a procaine-1,3,5-triazine (PT) derivative on Complete Freund’s Adjuvant (CFA)-induced arthritis in rats. The PT compound was synthesized with excellent yield and purity using a straightforward nucleophillic synthetic approach via reacting procaine with di-substituted 1,3,5-triazine derivative. Arthritis was induced using CFA, and the PT derivative was administered at varying doses (5, 10, and 15 mg/kg.body weight). Throughout the study, multiple physical and biochemical parameters were assessed to determine the therapeutic impact. PT treatment significantly reduced paw swelling and improved body weight in a dose-dependent manner. Biochemical analysis revealed a marked decrease in pro-inflammatory cytokines (TNF-α, IL-6, IL-1β, IL-17) along with an upregulation of anti-inflammatory cytokines (IL-10, IL-4), indicating a potent anti-inflammatory response. Additionally, PT restored oxidative stress markers—such as malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH)—to levels close to those in healthy controls. In summary, these findings demonstrate that the procaine-1,3,5-triazine derivative offers significant pharmacological benefits by alleviating CFA-induced rheumatoid arthritis through anti-inflammatory, and antioxidant actions.
Anticancer Activity of Melatonin and Metformin Alone and in Combination Against Melanoma and Breast Cancer Cells
Authors: Wawszczyk Joanna , Wolan Radosław , Kapral Małgorzata , Orchel Arkadiusz
Published: February 2025

In recent years, drug repositioning has received increasing attention, also in the context of cancer treatment. Among the drugs screened for new biological activities that could be used in therapeutic applications are metformin and melatonin. The aim of the study was to perform the predictive in silico study of potential outcomes of melatonin and metformin co-treatment and to evaluate the impact of melatonin and metformin individually and in combination on the growth of melanoma and breast cancer cells. Computer-based analysis identified diseases, proteins, and pathways that are susceptible to modulation by these two drugs simultaneously. Among proteins with the highest probability of interaction with both drugs are molecules relates to intracellular signaling pathways and apoptosis such as AKT kinase, MAPK8 kinase, mTOR, FOXO3, p53, and caspases. The results obtained revealed that the simultaneous use of melatonin and metformin exerted an additive or synergistic inhibitory impact on the growth of breast cancer cells, although this effect was not observed against melanoma cells. The synergistic effect of both compounds used together is caused by reducing cell proliferation and/or increasing apoptosis of breast cancer cell. In conclusion, the results presented indicate that the combination of melatonin and metformin may have a potential anticancer effect on breast cancer cells. However, additional studies are needed to evaluate the mechanism of action of the combined treatment of melatonin and metformin on cancer cells.
Golem V2 Biorelevant Dissolution Device: Tapping the Potential in Prolonged Release Matrix Tablets
Authors: Bílik Tomáš , Elbl Jan , Kubová Kateřina , Muselík Jan , Koutná Gabriela , Čulen Martin , Vysloužil Jakub
Published: February 2025

Dynamic biorelevant dissolution devices are becoming an important part of pharmaceutical research and development. Golem v2 represents such instrument. The aim of the study was to examine its potential for standard hydrophilic, lipophilic and dual matrices evaluation. The effect of agitation rate was observed. The obtained profiles were assessed by difference and similarity factors, compared to USP II profiles. Selected kinetic and release mechanism models were employed. Hydrophilic matrices differed in modified release excipient hydroxypropylmethylcellulose (10 to 30%) and apart the lowest 10% concentration the profiles were found similar to standard dissolution. Lipophilic matrices differed in tablet hardness, which was shown a major factor resulting in different profiles. Their Golem v2 profiles were also not similar with corresponding USP II dissolution profiles, hinting at possible discriminatory differences and intriguing options in erosion-based dosage forms. Similar behaviour was observed in dual matrix tablets. The different agitation rates yielded similar profiles. In addition, pressure and force values were measured using elements of own construction. Depending on the volume and agitation rate, the difference pressure ranged from 0.29 ± 0.04 kPa to 1.66 ± 0.03 kPa, suggesting values similar to pressure baseline in vivo.
Pengaruh Pendidikan dan Keterampilan Karyawan Dalam Penggunaan Teknologi Informasi Terhadap Kinerja Karyawan di Eran 4.0 pada PTPN IV Kebun Balimbingan
Authors: Sianturi Irma , Sagala Edison
Published: February 2025

Tujuan. Penelitian ini bertujuan untuk mengetahui dan menjelaskan pengaruh Pendidikan dan Keterampilan Karyawan dalam penggunaan Teknologi Informasi Terhadap Kinerja Karyawan di Era 4.0 Pada PT. Perkebunan Nusantara IV Kebun Balimbingan.
Metode. Populasi dalam penelitian ini berjumlah 210 karyawan, dengan jumlah sampel 68 responden. Yang menjadi responden merupakan karyawan PT. Perkebunan Nusantara IV Kebun Balimbingan yang bekerja menggunakan teknologi informasi.Teknik pengumpulan data yang digunakan adalah melalui observasi, studi pustaka, wawancara dan angket (Kuesioner) yang pengukurannya menggunakan skala Likert. Data diolah dengan program SmartPLS 4.0 for windows dengan menggunakan metode Model Pengukuran dan Model Struktural.
Hasil. Hasil penelitian menunjukkan bahwa Pendidikan berpengaruh positif dan signifikan terhadap Penggunaan Teknologi Informasi, Pendidikan memiliki pengaruh tidak signifikan terhadap Kinerja Karyawan, Keterampilan Karyawan berpengaruh positif dan signifikan terhadap Penggunaan Teknologi Informasi, Keterampilan Karyawan berpengaruh positif dan signifikan terhadap Kinerja Karyawan, Pendidikan dalam Penggunaan Teknologi Informasi memiliki pengaruh tidak signifikan terhadap Kinerja Karyawan, dan Keterampilan Karyawan dalam Penggunaan Teknologi Informasi memiliki pengaruh tidak signifikan terhadap Kinerja Karyawan.
Implikasi. Keberhasilan dalam mencapai tujuan perusahaan sangat dipengaruhi oleh kinerja individu karyawan. Perusahaan diharapkan selalu berupaya meningkatkan kinerja karyawan dengan harapan tercapainya tujuan perusahaan. Yang mana, perusahaan harus memperhatikan pendidikan dan keterampilan karyawan terhusus dalam menggunakan teknologi informasi. Selain itu dalam memperoleh karyawan yang handal diperlukan pelatihan atau pendidikan yang mendukung keterampilan dan motivasi kinerja karyawan.
Pengaruh Work Life Balance dan Beban Kerja terhadap Kinerja Pegawai Badan Kepegawaian dan Pengembangan Sumber Daya Manusia (BKPSDM) Kabupaten Karawang
Authors: Maulani Dinda Sopha , Marliani Sari , Yuliawati July
Published: February 2025

Tujuan. Penelitian ini bertujuan untuk mengetahui pengaruh Work Life Balance dan Beban Kerja terhadap Kinerja Pegawai Badan Kepegawaian dan Pengembangan Sumber Daya Manusia (BKPSDM) Kabupaten Karawang.
Metode. Penelitian ini menggunakan metode kuantitatif deskriptif dan verifikatif. Pengambilan sampel menggunakan sampel jenuh, yaitu seluruh populasi sebanyak 53 pegawai dijadikan sampel. Pengumpulan data dilakukan melalui kuesioner.  Analisis data menggunakan regresi linier bergandan dengan software SPSS.
Hasil. Hasil dari penelitian adalah work-life balance pegawai sangat baik, beban kerja pegawai tinggi, kinerja pegawai sangat baik, work-life balance berpengaruh positif secara parsial terhadap kinerja pegawai, beban kerja berpengaruh negatif secara parsial terhadap kinerja pegawai, dan work-life balance dan beban kerja berpengaruh positif secara simultan terhadap kinerja pegawai.
Implikasi. Pada penelitian selanjutnya dapat mengambil variabel lain yang dapat meningkatkan kinerja pegawai, antara lain motivasi kerja, budaya organisasi, disiplin kerja dan lain-lain, serta jumlah populasi dan sampel dalam penelitian perlu diperluas untuk memperoleh hasil yang lebih memuaskan.
Pengaruh Fitur Layanan, Privasi Keamanan dan Kepercayaan Terhadap Kepuasan Pengguna Aplikasi Dana Sebagai Alat Pembayaran (Studi Pada Mahasiswa Prodi Manajemen Unimed)
Authors: Saragih Sindy Aliffiyah , Siregar Zulkarnain
Published: February 2025

Tujuan. Penelitian ini bertujuan untuk mengetahui apakah terdapat pengaruh dari fitur layanan, privasi keamanan dan kepercayaan terhadap kepuasan pengguna  aplikasi DANA sebagai alat pembayaran studi pada mahasiswa prodi manajemen UNIMED.
Metode. Penelitian ini menggunakan pendekatan kuantitatif. Teknik pengambilan sampel dalam penelitian ini menggunakan teknik pendekatan porposive sampling dengan jumlah sampel sebanyak 100 responden menggunakan metode analisis data partial last square yang didukung oleh SmartPLS vers 4.0 bersama dengan pendekatan Model Structural Equation (SEM).
Hasil. Hasil dari penelitian ini menyatakan bahwa: 1) fitur layanan tidak berpengaruh secara signifikan terhadap kepuasan pengguna, 2) privasi keamanan tidak berpengaruh secara signifikan terhadap kepuasan pengguna, 3) kepercayaan berpengaruh secara signifikan terhadap kepuasan pengguna, 4) kepercayaan mampu memediasi fitur layanan terhadap kepuasan secara signifikan, 5) kepercayaan mampu memediasi privasi kepercayaan terhadap kepuasan pengguna.
Implikasi. Perusahaan aplikasi perlu meningkatkan fitur layanan dan privasi keamanan untuk memastikan kepuasan dan keamanan pengguna. Selain itu, penting untuk tetap mempertahankan dan meningkatkan kepercayaan pengguna dengan terus memenuhi harapan mereka, sehingga reputasi baik perusahaan terjaga.
Analisis Rasio Keuangan Perusahaan Asuransi Studi Kasus PT Asuransi Tugu Pratamaindonesia Tbk Periode 2019-2023
Authors: Kertonegoro Sudrajat , Rumpoko Rumpoko , Nugrahani Annisa Dewita
Published: February 2025

Tujuan. Penelitian ini bertujuan untuk mengetahui kinerja keuangan perusahaan pada PT Asuransi Tugu Pratama Indonesia Tbk Periode 2019-2023. Dengan menggunakan metode analisis rasio keuangan, Solvency and Profitability Ratio, Liquid Ratio, Premium Stability Ratio, dan Technical Ratio.
Metode. Metode yang digunakan berdasarkan Pernyataan Standar Akuntansi Keuangan (PSAK) No. 28 tentang Akuntansi Asuransi Kerugian. Jenis penelitian ini termasuk dalam penelitian deskriptif dengan menggunakan pendekatan kuantitatif.
Hasil. Hasil analisis rasio keuangan dan rasio Solvency and Profitability ratio terhadap kinerja keuangan yang terdiri dari 6 (enam) rasio yang diuji hanya 2 (dua) rasio yang menunjukkan indikasi kurang baik yaitu pada underwriting ratio dan investment yield ratio. Pada Liquid Ratio menunjukan hasil yang cukup baik. Pada Premium Stability Ratio cenderung menunjukan hasil yang kurang baik, sedangkan pada Technical Ratio menunjukkan berada di kategori baik.
Implikasi. Hasil analisis dapat membantu manajemen dalam pengambilan keputusan strategis, serta memberikan panduan bagi investor dan regulator dalam menilai stabilitas dan efisiensi perusahaan di industri asuransi.
Pengaruh Sensory Marketing Terhadap Repurchase Intention Melalui Brand Experience Sebagai Variabel Intervening (Studi Pada KKV Indonesia)
Authors: Permana Rachman Indera , Kristi Avenita Regita
Published: February 2025

Tujuan. Penelitian ini bertujuan untuk mengetahui pengaruh sensory marketing terhadap repurchase intention melalui brand experience sebagai variabel intervening pada brand KKV Indonesia
Metode. Penelitian ini menggunakan metode kuantitatif dengan pengumpulan data primer melalui kuesioner yang diperoleh dari responden. Responden dalam penelitian ini adalahh konsumen yang pernah membeli produk KKV Indonesia. Analisis data akan dilakukan menggunakan Structural Equation Modelling - Partial Least Square (SEM-PLS).
Hasil. Hasil dari penelitian ini adalah terdapat pengaruh antara sensory marketing, brand experience, dan repurchase intention
Implikasi. Implikasi praktis dari penelitian ini akan membantu perusahaan dalam merancang strategi pemasaran yang lebih efektif untuk meningkatkan loyalitas konsumen dan keberhasilan merek
Copper promoted, direct sulfenylation of n-aryl pyrazoles
Authors:   Faculty of Chemical Engineering, Ho Chi Minh City University of Technology (HCMUT), VNU-HCM, Ho Chi Minh City, Nguyen Tung Thanh ,   VNU-HCM Key Laboratory for Functional Organic Materials, Pham Anh Quoc ,   Faculty of Chemical Engineering, Ho Chi Minh City University of Technology (HCMUT), VNU-HCM, Ho Chi Minh City; VNU-HCM Key Laboratory for Functional Organic Materials, Pham Hai Hoang ,   Faculty of Chemical Engineering, Ho Chi Minh City University of Technology (HCMUT), VNU-HCM, Ho Chi Minh City; VNU-HCM Key Laboratory for Functional Organic Materials, Le Ha Vu ,   Faculty of Chemical Engineering, Ho Chi Minh City University of Technology (HCMUT), VNU-HCM, Ho Chi Minh City; VNU-HCM Key Laboratory for Functional Organic Materials
Published: February 2025

Direct functionalization of N-heterocycles often attracts substantial attention, as the targeted compounds find ubiquitous uses in many applications. Among common N-heterocycles, substituted pyrazoles are still challenging compounds for functionalization, though commonly useful in bio- and material-related studies. Herein, we report a general method for direct sulfenylation at the C4-H bonds of pyrazoles with diaryl disulfides. This transformation produces unsymmetrical thioethers, which often require the use of pre-functionalized starting materials and partners with unpleasant smells. Our reaction conditions involve the use of a CuCl2 catalyst, K2S2O8 oxidant, and CH3COOH as the solvent. A wide range of functionalities, including bromo, chloro, and nitro groups, were well-compatible. A possible mechanism, including electrophilic sulfenylation, was proposed.