bluuebunny/crossref_metadata_2025 huggingface dataset:
POTENSI KOMBINASI AMIDO-BRIDGED NUCLEIC ACID MODIFIED ANTISENSE OLIGONUCLEOTIDES DENGAN POLYAMIDOAMINE DENDRIMER GENERASI 4 TERTARGET Α-SYNUCLEIN SEBAGAI TERAPI PARKINSON
Authors: Aristadewi Putu Aprilyanti , Gorintha Adrian Wiryanata , Ivena Andrea
Published: March 2021

Parkinson adalah penyakit neurodegeneratif yang meningkat lebih cepat daripada gangguan neurologis lainnya. Saat ini pengobatan Parkinson menggunakan dopamine agonist dan levodopa, namun pengobatan ini memiliki efek samping seperti menurunkan nafsu makan dan tidak berfokus pada pencegahan kematian neuron. Salah satu protein yang berperan dalam patogenesis dari Parkinson adalah protein α-synuclein, di mana agregasi dan misfolding dari protein ini bersifat toksik pada neuron sehingga mendukung progresi Parkinson. Antisense oligonucleotide (ASO) yang dikombinasikan dengan amido-bridge nucleic acid (AmNA) diketahui memiliki efek untuk menekan ekspresi mRNA α-synuclein namun hanya sebagian kecil dosis yang terdistribusi ke jaringan target sehingga diperlukan karier yang stabil. Polyamidoamine (PAMAM) Dendrimer menjadi pilihan dengan kemampuan menembus Blood Brain Barrier dan menarget organ secara spesifik. Secara khusus, PAMAM Dendrimer Generasi 4 (PAMAM G4) dapat menghambat agregasi protein α-synuclein. Oleh karena itu, mengombinasikan potensi yang dimiliki oleh AmNA-ASO dengan PAMAM Dendrimer Generasi 4 menggunakan larutan HEPES buffer diharapkan mampu menjadi terapi Parkinson yang menjanjikan.
Eating behaviours of normal and overweight female undergraduate students in positive and negative emotions
Authors: Sidek S. , Mat Hassan N.A.A. , Hamirudin A.H. , Mohd. Abu Bakar W.A. , Irfan Unal T.
Published: March 2021

Emotional well-being affects eating behaviour, whether making an individual eat less or
more than they normally do. This paper aimed to compare eating behaviour between
normal and overweight female undergraduate students in response to positive and negative
emotions. This cross-sectional study was conducted among 166 female university
students. Data collection involved the assessments of participants’ anthropometric
measurements to obtain body mass index (BMI) and two self-administered questionnaires
to measure of eating behaviour in positive and negative emotions; Emotional Appetite
Questionnaire (EMAQ) and Eating Junk Food Questionnaire (EJFQ). Data from the two
groups were compared to obtain differences in eating behaviour between normal and
overweight female undergraduate students in response to positive and negative emotions.
Both normal (Mean = 5.96±1.05) and overweight (Mean = 5.60±0.81) participants
reported no changes in the levels of eating under positive emotions. The results also
showed that both BMI categories “ate less” when they experienced negative emotions. For
EJFQ, there was no significant difference in eating junk food between normal and
overweight participants in response to positive emotions. However, the results revealed
that the overweight group has more tendency to choose pizza (X
2
(1) = 6.879), p = 0.009)
and cake (X
2
(1) = 7.458, p = 0.006) than the normal group under negative emotions. These
results offer an insight that both BMI groups have almost similar eating-related concerns
and thus intervention programs can be constructed on distressing eating-related thoughts
and emotions among female undergraduate students
العولمة والعنف دراسة سوسيو انثروبولوجية في ظل العولمة
Authors: Saeed H. Ahmed Mohammad , Haso Zebari Tahir
Published: March 2021

يتلخص هذه الدراسة حول العلاقة بين العولمة والعنف من منظور مفكري علم الإجتماع والأنثروبولوجيا. حيث أن ظاهرة العولمة تعتبر ظاهرة سوسيولوجية عالمية ومحلية، ولم تتأخر أثارها الايجابية منها والسلبية في البروز سريعاً والتي تطرح تحديات جديدة تقف أمام المجتمع الإنساني. ولقد ركزت هذه الدراسة على الكشف عن ماهية العولمة وعلاقتها بالأشكال الجديدة (المستحدثة) للعنف وإعادة تصديرها لدول العالم عموماً ودول الجنوب (النامية) على وجه التحديد بصورة مطابقة لنشاطاتها وأهدافها و قيمها وطابعها الممارس مما أدى إلى ظهور ملامح وضع دولي معقد ومتأزم تسوده الصراعات والنزاعات على جميع الأصعدة. ولقد كانت ظاهرة العنف من ابرز المشكلات الاجتماعية التي تساهم العولمة في إنتاجها في صور وأشكال جديدة، مثل العنف الإقتصادي، العنف السياسي، العنف الثقافي. وإزاء هذه التحولات العالمية الكبرى التي ترتبت على ظاهرة العولمة حاول بعض علماء الأنثروبولوجيا المعاصرين دراسة العنف من هذا المنظور. خلاصة عامة: العولمة تساهم بشكل كبير في ظهور وترسيخ أشكال جديدة للعنف في المجتمعات المعاصرة "فالعنف هو الوجه الآخر للعولمة".
Fighting words in the antipodes
Authors: Lacey C , Kelly MP , Jutel Annemarie
Published: March 2021

© 2020 by Johns Hopkins University Press. In this commentary, written in two bursts—the first completed in April 2020, and the second at the end of July—we explore how media metaphors of COVID-19 constitute the pandemic in Australia and New Zealand. We argue that the media’s rhetorical strategies play an important role not only in describing the illness, but in influencing and shaping individual and collective responses to the pandemic, with significant consequences for mental health and well-being in the context of crisis. We align this commentary with the tenets of the sociology of diagnosis, which argue that even though there are material realities of disease, their social form and conse-quence cannot be separated from the tangible nature of illness and its management. We also lean on Derrida’s approach to metaphor, which underlines how even observable viral entities such as COVID-19 are simultaneously material, abstract, and in flux. We describe the metaphors used by local media to describe the pandemic—including combat, bush fires, earthquakes, and other natural disasters—and we explore how and why these metaphors construct the pandemic locally and farther afield.
Face masks for the public during covid-19: The more things change
Authors: Jutel Annemarie
Published: March 2021

No description supplied
Wisdom on elusive diagnoses
Authors: Jutel Annemarie
Published: March 2021

No description supplied
Seismic observations of crevasse growth following rain-induced glacier acceleration, Haupapa/Tasman Glacier, New Zealand
Authors: Taylor-Offord S , Horgan Huw , Townend John , Winberry JP
Published: March 2021

Copyright © The Author(s) 2019 This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.. Changing rates of water input can affect both the flow of glaciers and ice sheets and their propensity to crevasse. Here we examine geodetic and seismic observations during two substantial (10-18-times background velocity) rain-induced glacier accelerations at Haupapa/Tasman Glacier, New Zealand. Changes in rain rate result in glacier acceleration and associated uplift, which propagate down-glacier. This pattern of acceleration results in a change to the strain rate field, which correlates with an order of magnitude increase in the apparent seismicity rate and an overall down-glacier migration in located seismicity. After each acceleration event the apparent seismicity rate decreases to below the pre-acceleration rate for 3 days. This suggests that seismic events associated with surface crevasse growth occur early during phases of glacier acceleration due to elevated extensional stresses, and then do not occur again until stresses recover.
Perspectivas de las intervenciones de la fisioterapia respiratoria en cuidado intensivo frente al COVID-19
Authors: Torres José Ignacio Torres , Reyes Mabel Margoth , Moreno Collazos Jorge Enrique , Pinzón Iván Darío , Rodríguez Lizeth Catherine
Published: March 2021

La infección por COVID-19 ha afectado a la población mundial y a los sistemas de salud que le han hecho frente. No obstante, los efectos respiratorios abordados desde fisioterapia aún son inciertos. Por lo tanto, esta revisión de literatura tiene como objetivo establecer las perspectivas de las intervenciones desde la fisioterapia respiratoria en los sujetos infectados con COVID-19 donde se seleccionaron las bases de datos Pubmed, Medline, PEDro y Scielo en la búsqueda de artículos científicos y guías de manejo en idioma de inglés, portugués y español acerca de las bases moleculares y los efectos funcionales del COVID-19 sobre el sistema respiratorio. Se pudo concluir que la fisioterapia respiratoria implica un razonamiento clínico terapéutico acerca de los cambios celulares y morfológicos de los músculos respiratorios que se suscitan desde la patokinesis, intervenciones neumáticas, posicionamiento ventilatorio los cuales determinan efectos positivos en la disminución de complicaciones físicas, estancia hospitalaria y mejoría del desempeño físico y funcional.
A ESCRITA DE SINAIS COMO INSTRUMENTO DE DESENVOLVIMENTO LINGUÍSTICO E IDENTITÁRIO PARA O SURDO
Authors: Fernandes Francyllayans Karla da Silva , Alves Edneia de Oliveira , Stumpf Marianne Rossi
Published: March 2021

Sendo a língua de sinais uma manifestação cultural e identitário do surdo e possuindo ela a modalidade sinalizada e escrita, essa última modalidade no sistema signwriting. A escrita é um importante instrumento de empoderamento e desenvolvimento cognitivo e linguístico do surdo. Assim, defendemos que sua alfabetização deva ser realizada em sua escrita de sinais por ser sua primeira língua, assegurando-lhe a aquisição linguística como um período significativo, sem rupturas ou adaptações de uma língua (visualespacial) para outra (oral), com a qual ele não possui identificação. O objetivo geral desse trabalho foi verificar a aprendizagem da escrita de sinais pelo surdo. A pesquisa de natureza qualitativa, de caráter exploratório e delineamento de estudo de caso. O campo de pesquisa foi uma escola pública estadual e os participantes foram 6 sujeitos surdos. Analisou-se os dados por meio da técnica da migrogenética. Os dados indicaram que o surdo aprende com facilidade a escrita de sinais e que esses sujeitos se identificam com essa escrita por ser visoespacial.
DE LA TEXTURE DES DIÉGÈSES DES ÉCRIVAINES DE LA POSTCOLONIE À LA CONTEXTURE D’UNE MONDIALISATION ALTERNATIVE
Authors: Onana Pierre Suzanne Eyenga
Published: March 2021

Le choix porté sur le roman d’Anne-Marie Adiaffi, d’Angéline Solange Bonono et celui d’Edwidge Danticat pour conduire notre argumentation n’est pas fortuit. Il permet de mieux visualiser les relations intertextuelles qui lient une écrivaine ivoirienne et une romancière camerounaise et une auteure haïtienne dont les œuvres, pourtant, sont distantes de vingt-trois ans. L’une comme l’autre aborde la question des mariages pré-arrangés ou de la violence dans une perspective constructionniste qui remet au jour les affres de la société patriarcale qui caractérise à ce jour une partie de l’Afrique et maintient la femme dans la posture de « sexe faible ». Selon une double perspective critique se réclamant de l’approche genre et du comparatisme, il s’agit de scruter les modes de déclinaison de la mondialisation culturelle entre la Côte d’Ivoire, le Cameroun, Haïti et le monde, par-delà le socle linguistique et géographique qui oppose ces pays. Au regard des passerelles sémantiques que dégage finalement l’herméneutique desdites écrivaines, l’étude s’achève par la monstration des stratégies de restitution de la place de l’écrivaine comme actrice du vivre ensemble et militante féministe de la non-marginalisation de la femme dans la littérature mondiale.
DIFUSIÓN DE LA OBRA DE ESCRITORAS EN EL NUEVO TEATRO CRÍTICO DE EMILIA PARDO BAZÁN
Authors: Gámez Rocío Charques
Published: March 2021

En uno de los periodos de mayor acción feminista por parte de EmiliaPardo Bazán, cuyo nombre es reconocido a nivel internacional, la escritoracoruñesa lleva a cabo una empresa de gran ambición: su revista Nuevo TeatroCrítico (1891-1893). Ella financia, dirige y redacta cada número, donde aparecentrabajos de temática tan diversa como la crítica literaria, la reseña de eventosculturales o crónicas de viajes, entre otros. No todos los escritores a los quededica un artículo reciben gustosamente sus comentarios. La nómina deescritores es mayoritariamente masculina. En este trabajo nos detendremos enaquellos textos dedicados a las escritoras contemporáneas.
La filosofía de Bergson
Authors: Ibérico Rodríguez Mariano
Published: March 2021

Cuando apareció la filosofía bergsoniana en el cuadro intelectual de Europa, puede decirse que el pensamiento filosófico, tomado en conjunto y prescindiendo de algunos pensadores aislados de escasa difusión, o bien se mantenía en la pura abstención sistemática del positivismo o bien, cuando trascendía a la metafísica, erigía en absolutos determinados principios o hipótesis de las ciencias físicas. De ambas actitudes derivaba, como resultado final, la convicción a la vez científica y filosófica de que la totalidad del mundo puede ser interpretada como una composición mecánica de fuerzas.
Clear rings and clear elements
Authors: Zabavsky B. V. , Domsha O. V. , Romaniv O. M.
Published: March 2021

An element of a ring $R$ is called clear if it is a sum of a unit-regular element and a unit. An associative ring is clear if each of its elements is clear.In this paper we defined clear rings and extended many results to a wider class. Finally, we proved that a commutative Bezout domain is an elementary divisor ring if and only if every full $2\times 2$ matrix over it is nontrivially clear.
Finitary approximations of coarse structures
Authors: Protasov I. V.
Published: March 2021

A coarse structure $ \mathcal{E}$ on a set $X$ is called finitary if, for each entourage $E\in \mathcal{E}$, there exists a natural number $n$ such that $ E[x]< n $ for each $x\in X$. By a finitary approximation of a coarse structure $ \mathcal{E}^\prime$, we mean any finitary coarse structure $ \mathcal{E}$ such that $ \mathcal{E}\subseteq \mathcal{E}^\prime$.If $\mathcal{E}^\prime$ has a countable base and $E[x]$ is finite for each $x\in X$ then $ \mathcal{E}^\prime$has a cellular finitary approximation $ \mathcal{E}$ such that the relations of linkness on subsets of $( X,\mathcal{E}^\prime)$ and $( X, \mathcal{E})$ coincide.This answers Question 6 from [8]: the class of cellular coarse spaces is not stable under linkness. We define and apply the strongest finitary approximation of a coarse structure.
IMPROVING THE ENTERPRISE PERFORMANCE ON THE BASIS OF APPLYING DECISION TREE METHOD
Authors: Feofanov Aleksandr , Egorov Mikhail
Published: March 2021

The article is devoted to considering the use of the decision tree method, defects at a machine-building enterprise, the reasons for having defects in the product and proposals for amending the normative and technical documentation. At the moment, non-destructive diagnostics methods have become widespread, which make it possible to determine the places of fault localization and predict the object state without the need for research which requires making object inoperative or its dismantling. The construction of the diagnostic models is implemented using the methods and tools of regression analysis, the theory of artificial neural networks, etc. However, they do not have a high level of generalization, and neural networks are difficult to interpret, which complicates their application in practice.
eBook Informação Ciência e Tecnologia Lectures Notes Simposio TOI 2020
Authors: PALETTA FRANCISCO CARLOS , da Silva Armando Malheiro
Published: March 2021

◼O I Simpósio Informação, Ciência, Tecnologia e Inovação --“Contribuições para a Ciência da Informação”, um dos eixos temáticos do VI Congresso Internacional Tecnologia e Organização da Informação, apresenta como proposta, debater temas relacionados aos desafios associados à gestão e organização da informação e do conhecimento na era digital frente as demandas tecnológicas e por inovação. O crescimento do Universo Digital induzido pelo fenômeno do Big Data possibilitou avanços significativos na área de Ciência de Dados, Humanidades Digitais e Inteligência Artificial, induzindo inovações nas atividades de ensino, pesquisa e extensão, ao mesmo tempo que amplia o campo de atuação de profissionais das áreas da Ciência da Informação no uso das tecnologias da informação e comunicação◼ Uma característica distintiva da Ciência da Informação é o cultivo de uma relação bidirecional entre as a gestão e organização da informação e do conhecimento e o digital o campo emprega tecnologias na pesquisa e no estudo de temas relevantes para a Biblioteconomia, Arquivologia e Museologia fazendo uso de soluções inovadoras à serviço das Ciências Sociais◼ Tem como foco profissionais da área da Ciência da Informação, bibliotecários, arquivistas, museólogos, profissionais da informação, pesquisadores, estudantes, empresas, startups, gestores, analistas, especialistas e consultores que atuam na área de gestão e organização da informação na Era Digital◼ Este evento faz parte do VI Congresso Internacional em Tecnologia e Organização da Informação, iniciativa do Departamento de Informação e Cultura da ECA USP e do Observatório do Mercado de Trabalho em Informação e Documentação OMTID_CNPq em colaboração com o CITCEM da Universidade do Porto e Lti UFPB
Bahasa Indonesia 672020215
Authors: Aldio Muhamad
Published: March 2021

Menjelaskan tentang bagaimana kemiskinan di Indonesia
Protocol: Overviews of Reviews of the comorbidities, symptoms and perinatal clinical characteristics of patients with coronavirus 2019 (COVID-19)
Authors: Vasco-Morales Santiago , Vasco-Toapanta Cristhian , Toapanta-Pinta Paola
Published: March 2021

What is the incidence in pregnant women of: preterm labor, C-section operation, pneumonia, cough, fever, radiological alterations in the chest, alterations in the blood count, liver function, C-reactive protein, procalcitonin, high D-dimer, thrombocytopenia, globular sedimentation rate.What is the incidence in the neonate of: low birth weight, fetal well-being commitment, low Apgar score, radiological alterations in chest, alterations in the blood count, liver function, C-reactive protein, procalcitonin, high D-dimer, thrombocytopenia, and what is the globular sedimentation rate, the vertical transmission of COVID-19 symptoms, and what are the clinical characteristics?
Ritual Mistis di Dunia Politik: Studi pada Ritual Ngalab Berkah di Gunung Kemukus
Authors: pradana galih bintang
Published: March 2021

Secara faktual, ritual mistis masih diyakini dan dilakukan oleh masyarakat di era modern. Di era politik, ritual mistis dilakukan oleh para kontestasi politik. Gunung Kemukus salah satu tempat yang didatangi untuk ritual. Dalam hal ini agama Jawa yang menjadi pemandu dalam melakukan ritual tersebut. Ritual mistis tersebut dipercaya dapat efektif sebagai jalan untuk memenangi kontestasi di dunia politik.
KLRC4 is differentially expressed in lymph node metastasis in human breast cancer.
Authors: Mamoor Shahan
Published: March 2021

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). Between the breast and the brain reside the secondary lymphoid organ, the lymph nodes. We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with metastasis to the lymph nodes in humans with metastatic breast cancer. We found that killer cell lectin like receptor C4, KLRC4, was among the genes whose expression was most different in the lymph node metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. Analysis of a separate microarray dataset revealed that KLRC4 was also differentially expressed in brain metastatic tissues. KLRC4 mRNA was present at increased quantities in lymph node metastases as compared to primary tumors of the breast. Importantly, expression of KLRC4 in primary tumors of the breast was correlated with patient recurrence-free survival, in lymph node negative patients but not in lymph node positive patients. Modulation of KLRC4 expression may be relevant to the biology by which tumor cells metastasize from the breast to the lymph nodes and the brain in humans with metastatic breast cancer.
MANFAAT AKAR GINSENG JAWA PADA MASALAH INFERTILITAS
Authors: DARI TANTY WULAN
Published: March 2021

Masalah infertilitas pria menunjukkan peningkatan, karena menurut observasi di beberapa negara menunjukkan gejala penurunan jumlah, kualitas dan kuantitas sperma yang cukup menyolok di antara pria dewasa muda (Pusdiknakes, 2000). Hal tersebut diakibatkan oleh berbagai faktor, misalnya gangguan hormon, pengaruh obat, radiasi, keracunan pestisida, infeksi, dan rokok. Untuk mencegah masalah infertilitas pasangan suami istri, maka ginseng Jawa yang merupakan salah satu tumbuhan afrodisiak, mengandung senyawa-senyawa turunan saponin, tanin dan senyawa lainnya yang secara fisiologis dapat melancarkan sirkulasi pada sistem syaraf pusat dan meningkatkan aktivitas hormonal yaitu hormon androgenik. Sehingga dapat mempertahankan jumlah sel spermatogenik, morfologi, dan motilitas spermatozoa dalam kuantitas dan kualitas spermatozoa.
Effect of Rhynchospora corymbosa and Olax subscorpioïdea two plants used in the management of Korhogo sickle cell disease
Authors: Soro M'béfèhê , Akakpo-Akue Joël , Ackah Jacques Auguste Alfred Bognan , Sibri Jean-François , Yapi Yayé Guillaume , Kple Tatiana Kangah Mireille
Published: March 2021

Sickle cell disease is the first genetic disease in the world. Rhynchospora corymbosa and Olax subscorpioïdea are two plant species used in traditional management of sickle cell disease in the department of Korhogo. After a chemical study of the decocted and the aqueous extract of these two plants, their effect on the in vitro reversal of sickling of HbSS genotype erythrocytes, has been evaluated according to Emmel method. An abundance of alkaloids, tannins, saponins, polyterpenes and sterols was found in the decocted and aqueous extract of Rhynchospora corymbosa (DRC and MRC). As for the decocted and aqueous extract of Olax subscorpioïdea (DOSA and MOSA), polyphenols, leucoanthocyanins and flavonoids were found in addition to the chemical compounds identified in Rhynchospora corymbosa. At the concentration of 0.312 mg/mL DRC, MRC DOSA and MOSA have obtained the reversal rate of 75, 50, 80 and 80% respectively. All four extracts demonstrated activity on in vitro reversal of sickle cells. This activity could be caused by the presence of chemical groups that would be used in the treatment of several diseases because of their anti-oxidant and anti-inflammatory properties. Rhynchospora corymbosa and Olax subscorpioïdea are both an effect on the in vitro sickling reversal. Their use in the management of sickle cell disease in northern Côte d'Ivoire might be justified.
In vitro antioxidant and anti-arthritic effect of the aqueous and ethanolic leaf and root bark extract of Alafia barteri
Authors: Kolawole Ikeoluwapo Olanike , Ebuehi Osareti Albert Taiwo , Awoyera Esther Ayomide
Published: March 2021

Alafia barteri (Apocynaceae) is a climbing shrub having white or pink flowers. Traditionally, it has been used to treat diseases like malaria, sickle cell anemia, and eye infections. This research is focused on investigating the antioxidant and anti-arthritic activities of the aqueous and ethanol leaf and root extract of Alafia barteri plant in vitro. In-vitro antioxidant methods used were 2, 2 -diphenyl-1-picrylhydrazyl assay, reducing power activity and hydrogen peroxide scavenging assay while the anti-arthritic activity was studied using the assay method of protein denaturation. Results revealed that aqueous and ethanol root extracts scavenge free radicals, thus inhibiting damage caused by oxidative stress in arthritis while the ethanol extracts of both the leaf and roots had good anti-arthritic activities as seen in its ability to decrease protein denaturation.
PSYCHOLOGICAL APPROACHES OF IMPROVEMENT OF THE EFFICIENCY OF COMMUNICATION IN THE CONDITIONS OF ANTI-CRISIS MANAGEMENT
Authors: Vovk N. P.  , Diachkova O. M.  , Mokhnar L. I.
Published: March 2021

The psychological approaches for improvement of efficiency of organization and communication in anti-crisis management, based on the explication of the concepts “crisis situation”, “anti-crisis management”, “social communication”, “communication in a crisis”, as well as based on the analysis of the application of theories and models of communication in management in emergencies are defined in the article.
MOLECULAR AND GENETIC MECHANISMS OF DEVELOPMENT OF CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA AND THEIR CORRECTION ALLIC BFM 2009 BY CYTOSTATIC THERAPY
Authors: Vynnytska O. A.
Published: March 2021

The aim of this study was to evaluate the prognostic value of the relationship between genetic abnormalities and clinical and laboratory parameters of peripheral blood and bone marrow in children with acute lymphoblastic leukemia (ALL).Material and methods. 105 children diagnosed with ALL were examined (average age 6 years). To detect chromosomal translocations AF4/MLL t(4; 11) (q23; p23), BCR/ABL t (9; 22) (q34; q11), E2A/PBX1 t (1; 19) (q23; p13) and TEL/AML t(12; 21) (q13; q22) the method of polymerase chain reaction with reverse transcription (RT-PCR) was applicated. PCR was performed with specific primers for the appropriate chromosomal aberrations. Detection of PCR products was performed by electrophoresis in 2% agarose gel. Determination of minimal residual disease (MRD) was performed by multiparameter flow cytofluorimetry using monoclonal antibodies.Results. Among patients, the incidence of ALL is most pronounced in children aged 3 to 6 years - 37 people (35.2%) and aged 6 to 9 years - 26 people (24.8%). The highest accidence was found among patients with chromosomal translocation TEL / AML - 22 (21%) of patients with a median age 5 years. In second place, the frequency of mutations is the translocation of E2A / PBX1. BCR / ABL translocation was less common - 1.9% of patients, but the expression of this gene indicates a bad course of the disease, as patients after cytostatic therapy under the ALLIC BFM 2009 program had a recurrence. Recurrence has also been observed in patients with TEL/AML chromosomal translocation.Determination of MRD showed its increased level in patients with chromosomal aberrations BCR / ABL and TEL/AML throughout the treatment phase. In addition, patients in these groups were diagnosed with initial leukocytosis followed by leukopenia after a course of chemotherapy. Patients of all groups showed a decrease in hemoglobin.Conclusion. The biggest changes in clinical and laboratory parameters were found between patients with chromosomal translocations BCR/ABL and TEL/AML, as evidenced by the development of relapses in patients of these groups. The low level of association between karyotype disorders, with the formation of AF4/MLL and E2A/PBX1, and clinical and laboratory parameters in patients with GLL may indicate that the isolated clonal disorders are independent prognostic factors for the course of the disease.
ДОСЛІДЖЕННЯ РІВНЯ ЯКОСТІ ТРАНСПОРТНИХ ПОСЛУГ НА ПРИМІСЬКИХ АВТОБУСНИХ МАРШРУТАХ
Authors: Прокудін Г. С.  , Коп’як Н.В.  , Кузьмич В.П.
Published: March 2021

The article addresses the problems of the evaluation methodology improvement of the transport service efficiency and quality provided to passengers on suburban bus routes in accordance with the modern management system requirements. The purpose of the study is to provide practical recommendations to motor transport enterprises following which they can improve the level of service provided to suburban bus route passengers, as well as to provide a structured approach that will allow transport organizations to respond objectively and reasonably to requests resulting from new passenger transportation needs. For a comprehensive assessment of quantitative and qualitative transport service indicators, the evaluation method of the transport service efficiency is proposed. This approach makes it possible to reflect the transport service level both through the prism of enterprises` operation efficiency and the quality of transport service provision. The results of the study are of practical importance in the application of such methods in motor transport enterprises` activity providing the necessary information for management in modern business conditions.
МЕТОД ЭКСПЛУАТАЦИОННОГО УПРАВЛЕНИЯ ТРАНСПОРТНОЙ ЭНЕРГОЭФФЕКТИВНОСТЬЮ АВТОМОБИЛЯ МАЛОЙ ГРУЗОПОДЪЕМНОСТИ
Authors: Галёна И. И.  , Пицык М. Г.
Published: March 2021

Considering the relevance of the scientific and technical problem of the light-duty vehicles’ energy efficiency operational control and transportation processes in a market economy, it is necessary to create methods for its solution at different stages of this cycle. The methods of the general use vehicles energy-resource efficiency theory are used to eliminate the paradoxical fragmentation of knowledge about the life cycle stages.Mathematical models of the transport energy efficiency indicators have been developed to meet the operational and technological challenges of the energy-saving reproduction of the road transport services at all stages of the light-duty vehicle life cycle.Based on the models developed, a method is proposed. This method will make it possible to choose a light-duty vehicle with the characteristics corresponding the development of the technical basis of the transport system according to the concept of operational and technological energy saving, and strategies to improve the technical and technological competitiveness of the future transport proposals.
ПОБУДОВА ТРЕНУВАЛЬНОГО ПРОЦЕСУ У СПОРТСМЕНІВ З МІЖНАРОДНОГО ВІЙСЬКОВО-АВІАЦІЙНОГО П’ЯТИБОРСТВА ДЛЯ УЧАСТІ У СПОРТИВНОМУ КОНКУРСІ (ПОДОЛАННЯ СМУГИ ПЕРЕШКОД І СПОРТИВНЕ ОРІЄНТУВАННЯ)
Authors: Andrii Poltavets  , Andriy Kyyko  , Viacheslav Mulyk
Published: March 2021

Objective: to increase the efficiency of the training process of athletes in military aviation pentathlon through the additional introduction of crossfit exercises and cognitive training. Material and methods of research: analysis of literature sources, questionnaires, testing, statistical analysis. The study involved 48 first-year cadets of the Ivan Kozhedub Kharkiv National University of the Air Force (men), aged 17-18, including 38 candidates for masters of sports and 10 masters of sports. The obtained results: a combination in a single algorithm of training first-year cadets - candidates for the national team with VAP exercises for the development of motor coordination skills, develop the maximum number of competencies (motor abilities). Using crossfit exercises with maximum agility, accuracy, balance, flexibility, mobility in the joints, jumping, accuracy, rhythm and plasticity allow cadets to develop maximum physical performance and endurance. Conclusions: Exercises for the development of cognitive abilities allow you to understand in more detail and then perform new exercises, to concentrate as much as possible on the ultimate goal of the exercises. Pilates largely avoids high impact, high power output, and heavy muscular and skeletal loading. Pilates largely avoids high impact, high power output, and heavy muscular and skeletal loading.
Laparocenteza as a Method for Diagnosing Injuries of the Abdominal Cavity Organs
Authors: Ivanovich Shaposhnikov
Published: March 2021

The author recommends recourse to the laparocenteza in the diagnosis of closed abdominal injuries. Its use allows for a few minutes to recognize a catastrophe in the abdominal cavity. However, the traditional method of laparocenteza carries a certain danger. In this he became convinced during his work in various hospitals in Russia.
Clomiphene-Metformin in Comparison with Letrozole-Metformin in Overweight Infertile Women with PCOS
Authors: EL-Gharib Mohamed
Published: March 2021

Background: polycystic ovarian syndrome (PCOS) is a common cause of infertility and is associated with chronic anovulation and hyperandrogenemia. Clomiphene citrate (CC) is still the first-line therapy for ovulation induction in these patients. Metformin, a biguanide, has been used to treat insulin resistance in women with PCOS. Furthermore, many reports confirmed that the addition of metformin to CC in the CC-resistant PCOS was highly effective in achieving ovulation. Letrozole, an aromatase inhibitor, has attracted attention for a long time to induce ovulation. Aim of the work: In the current study, we aimed to compare the effect of administration of combined metformin–Clomiphene Citrate to that of combined metformin–letrozole in the induction of ovulation in infertile overweight women with PCOS. 40 infertile overweight cases with PCO were included. Methods: Sixty participants had received metformin in aggregate with both CC (100 mg) or and similar number received letrozole (5 mg) plus metformin for 5 days starting from 3rd day of their menstrual cycle. Results: The cumulative pregnancy rate CC-metformin was 21.66% and letrozole-metformin was 25%, the difference is insignificant. Conclusion: CC and letrozole are similarly viable in the treatment of overweight women with PCOS, when joined with metformin treatment.
Prevalence and factors associated with anemia in pregnancy among women receiving antenatal care at the West Gonja District Hospital of Northern Ghana.
Authors: Malick Martin
Published: March 2021

Background: Anemia in pregnancy is a major public health problem especially in Low and Middle-income countries (LMIC) including Ghana and is defined by the World Health Organization (WHO) as being present when the hemoglobin concentration in the peripheral blood is 11g/dl or less. In most African countries anemia in pregnancy occurs if the hemoglobin concentration falls below 10g/dl. Pregnant women are at a higher risk of developing anemia due to several factors such as hemodilution, nutritional factors, multiple gestation, socio-economic status and malaria infestation. Anemia in pregnancy is an important cause of maternal mortality and affects half of pregnant women worldwide; with 56% of West African pregnant women being anemic. The objective of this study is to assess the prevalence and identify the risk factors associated with anemia among pregnant women receiving antenatal care at the West Gonja Hospital (WGH) Methods: A cross-sectional was conducted with 136 pregnant women receiving antenatal care at the WGH between January 2017 to February 2018. Random sampling was used to select participants and data was collected using a structured questionnaire. Data was analyzed using the SPSS Version 24.0. Results: A total 71(52.2%) of the study population were anemic, while 65 (47.8%) were not anemic. 20(74.1%) of the 27 pregnant housewives were anemic, while 11(64.7%) of the pregnant farmers were anemic. 27 (96.4%) of the 28 pregnant women who took their iron/folate supplement only some few days were anemic. 12 (100%) of the 12 participants who took their iron/folate supplement a few times a week were anemic. 4 (80%) of the 5 participants who never took their iron/folate supplement were anemic. 21 (70%) of those who did not sleep under ITN were anemic. 33 (84.6%) of the 39 patients who were diagnosed with malaria were also anemic. 28 (87.5%) of the 32 participants who took only 2 meals a day were anemic. 27 (79.4%) of the 34 patients who took liver, beef, chicken and fish only twice weekly were anemic. 15 (88.2%) of the 17 patients who drank tea some days in a week were anemic. Conclusion: Although most of the pregnant women were adequately educated on the most relevant aspects of anemia in pregnancy, more than half of them were still anemic. Anemia was more prevalent among pregnant uneducated housewives with poor nutritional habits. All the pregnant sickle cell disease patients as well as those diagnosed with malaria were also anemic.
A case report of cancer patient
Authors: Thero Ven
Published: March 2021

In India 25.8 per 10,000 women are suffering from Breast cancer as per the Ministry of Health & Welfare, India. It is estimated by 2020 around 1.7 million women will be suffering from breast cancer. Awareness and early detection can curb the growing burden of Breast Cancer and are the first step in the battle against Breast Cancer. The aim of this qualitative study was to explore the awareness and perceived barriers concerning the early detection of Breast Cancer. According to the National Cancer Registry Programme of the India Council of Medical Research (ICMR), more than 1300 Indians die every day due to cancer. Breast cancer is now the most common cancer among women in India, accounting for 27% of all cancers among women. The WHO data says India will have 1.16 million new cancer cases this year i.e. 2020 and more than 50 per cent of these will be diagnosed in women.
Clinical and In-Silico study of COVID?19 patients using Thymus capitatus extract as adjuvant Therapy
Authors: Gbaj Abdul
Published: March 2021

Thymus capitatus extract has been considered a promise as antiviral agent against COVID‑19 viruses. We hypothesized that Thymus capitatus components may interact with key protein targets of COVID‑19 (coronavirus 2 (SARS-CoV-2) causing severe acute respiratory syndromes. Molecular docking analysis was carried out using 31 components of Thymus capitatus with SARS-CoV-2 protease enzyme (6LU7) and spike glycoprotein (6VSB). The compounds with the best normalized docking scores to protease enzyme were allo-Aromadendrene (-6.3 kcal/mole), spathulenol (-6.6 kcal/mole) and ledene (-6.8 kcal/mole). The best docking ligands for spike glycoprotein were allo-Aromadendrene (-6.6 kcal/mole), spathulenol (-6.6 kcal/mole) and ledene (-7.3 kcal/mole). All Thymus capitatus components may act synergistically to produce the therapeutic action. Thymus capitatus components may potentiate the effect of prednisolone, azithromycin and other medicines used to treat COVID-19 patients.
To the question of the paradigm shift of psychiatry
Authors: SV Rosman
Published: March 2021

The main problem of psychiatry is that, having gained huge empirical experience in observing psychopathology, it has not become a full-fledged science. Perhaps this happened because Western medicine followed a path different from Eastern medicine - the path of deep study of private pro-phenomena of diseases and the search for their natural causes. However, huge problems lie along this path - the multifactorial impact of the external environment and the limited knowledge of man. As a result, a paradoxical state of affairs was created in psychiatrics and psychology: not a single objective method of research was created that allows you to diagnose mental illness due to the fact that there is still no one's idea of ​ ​ how the brain performs its main function - to think. That is, the reasons for psychiatry's failures lie in the deep crisis of neurophysiology.
Re-Print-A Comparison between Conventional Throat Packs and Pharyngeal Placement of Tampons in Rhinology Surgeries.
Authors: Alansari Hasan
Published: March 2021

Objective: the aim is to evaluate the incidence of postoperative throat pain, nausea and vomiting in patients that have been packed with either conventional gauze or pharyngeal tampons. Methods: We included adult patients who were booked for a rhinology surgery that needed throat packs. They were allocated into two groups, pharyngeal tampons, and conventional ribbon gauze. They were then assessed using visual analog scales and Post-operative nausea and vomiting impact scale respectively in the 1st, 4th, and 24th hour. Data was analyzed using SPSS software version 25. Results: There is evidence to suggest that using pharyngeal tampons reduces the mean VAS score at 4 hours compared to using Gauze. [t87=3.294, p=0.001), the is no statistical evidence that show a difference in the other Visual analogue scores or post-operative nausea and vomiting scores. Conclusion: The study shows that the use of pharyngeal tampons is associated with decreased pain scores, however, it also shows that there no difference in postoperative nausea and vomiting.
How can Head & Neck disorders be a liability to Indian population: Hindrance & Nuisance or Hesitance & Negligence???
Authors: Basavannaiah Sphoorthi
Published: March 2021

Introduction: Head & Neck disorders still remains a “global burden” in the world map till date. With the increasing trend of cancer in the present day scenario and raising parameters of aetiology with varied clinical occurrence, there has been a major plunge at the way things are perceived by a common man in day to day life. Aims & Objectives: To find out the various causes for Head & Neck disorder at our set up. Also to put together and touch upon aspects like risk factors, symptomatology associated with nature of the disease process in this belt of Malnad region. Methodology: 352 patients with Head & Neck disorders were considered for the study over a period of 1 year who were evaluated clinically and radiologically. After initial evaluation, most of them were referred to higher centre for further management. Results: Nearly 75% of patients presented with malignancy with 5 times predominance in males and around 97% patients belonging to the region from oral cavity up to larynx as they have a common epithelial origin. Conclusion: Head & Neck disorders are never to be neglected as it the “runway” to the crux of the body system. Any sort of limitation or hesitation can cost life and well-being.
Research on the Impact of Christianity on Roman Law in the Interwar Poland: Franciszek Bossowski’s Views
Authors: Nancka Grzegorz
Published: March 2021

The article is intended to present the views of Franciszek Bossowski on the impact of Christianity on Roman law and thus draws attention to the existing output of the Polish science of Roman law in this area. This Vilnius-based Roman law scholar was one of the few researchers in Poland who studied this issue in the interwar Poland. For this reason, the article encompasses an analysis of those of his works in which he touches upon the issue of the impact of Christianity on Roman law. Attention is drawn to the key theses formulated therein as well as his polemics with other scholars. Last but not least, the research postulates formulated by Bossowski are discussed.
Culture, Education and Truth. The Perspectives on Help Offered to Contemporary Youth
Authors: Królikowski Janusz
Published: March 2021

This paper focuses on three fundamental notions-realities which describe human life and constitute at the same time its foundation and the space of participation in it. The triad culture – education – truth describes the most essential human experiences, simultaneously, defining the direction of their deepening and creative developing. Certainly, in the times like these when everything is questioned notions-experiences that belong to this triad are not problem-free. What is more, they are deemed to be superfluous, especially in ultra-left-wing ideologies in which suicidal tendencies are easily discernible. Taking this into consideration, it is hardly possible to avoid polemic attitude towards numerous questions even those most essential since in their semantic field the greatest confusion may be detected. That is why there are numerous attempts to answer the question how, in the face of such a dynamic spiritual condition of the world, those fundamental issues can be dealt with within the frames of anthropology, and how they can be justified from the anthropological point of view. This reflection is rather philosophical in character, however, it is also inspired by the fundamental Christian truth which says about the incarnation of the Son of God and about the salvation of man made by Him.
Sacralità della vita umana nell’enciclica di Giovanni Paolo II "Evangelium vitae" – 25 anni dalla promulgazione
Authors: Kopiec Maksym Adam
Published: March 2021

Il presente testo riprende sinteticamente il messaggio dell’enciclica di san Giovanni Paolo II nel 25° anniversario della sua promulgazione, il 25 marzo 1995. Il fine di esporre e di ricordare i temi principali non è solo legato a questa ricorrenza, ma il fatto che proprio oggi il documento dimostra la sua straordinaria attualità, forse più che nei tempi quando era scritta. Questo permette di percepire il carisma profetico – teologicamente intesa – del santo papa, Giovanni Paolo II. Egli infatti, osservando certi fenomeni socio-culturali nel mondo e le idee che stavano alle loro base, ha deciso di ricordare l’annuncio della Chiesa che riguarda il mistero dell’uomo. Questo mistero risplende alla luce della Divina Rivelazione, cioè nel Vangelo che è la persona stessa di Cristo. Nei nostri tempi il Vangelo della vita suona con un particolare timbro e richiede di essere annunciato ad alta voce, davanti al mondo intero.
Prawda a ekumenizm – Benedykt XVI wobec anglikanów
Authors: Beyga Paweł
Published: March 2021

Ekumeniczna działalność jest niezwykle ważnym aspektem życia Kościoła katolickiego. Autor artykułu spojrzał na aktywność ekumeniczną w perspektywie nauczania Josepha Ratzingera – Benedykta XVI. Według papieża emerytaw Kościele katolickim po Vaticanum II najbardziej niebezpieczny dla ekumenizmu jest relatywizm. Specjalny dokument promulgowany przez papieża Benedykta XVI, zatytułowany Anglicanorum coetibus, był wspaniałym przykładem ekumenicznej działalności w katolickim i soborowym duchu. Artykuł ukazuje także ekumenizm w perspektywie soborowego Dekretu o ekumenizmie i liturgicznej wizji jedności Kościoła.
Communional Aspects of the Doctrine of the Holy Spirit According to John D. Zizioulas
Authors: Jagodziński Marek
Published: March 2021

What deserves emphasizing in the significant theological thought of John D. Zizioulas is his ecumenical openness and deep theology saturated with communion thought, which also produces the communion perspective of the reality of the Holy Spirit. Pneumatology has its origins in the Trinitarian-ecclesial reflection, which developed the fundamental concept of the Communion of the Holy Trinity. Zizioulas completely agrees with the Orthodox Trinitarian-pneumatological vision, which critically refers to the Trinitarian contribution of the thought of St. Augustine and he presents also a communional view on the contentious issue of Filioque – emphasizing the ecumenical perspectives of this topic and of ongoing dialogues which are still trying to bring the consensus of the Churches of East and West.
Man in the “Splendour of Divinity.” The Hagiological Interpretation of “spousal love” in line with John Paul II’s Theology of the Body
Authors: Parzych-Blakiewicz Katarzyna
Published: March 2021

The article presents the theological interpretation of the phenomenon of spousal love in terms of examining its correlations with the call to holiness. This study belongs to the field of hagiological research aiming at developing a new concept that defines arguments in the Church’s strategy concerning the defence of every human life. The analysis concerns the statements and philosophical writings of Karol Wojtyła and then John Paul II on spousal love and the dependence of the person and his actions on the Truth and Good. The Christological-soteriological aspect of spousal love as conditioning the sanctification of the person has been indicated. The axiological conditions related to the Christological assumption have been termed as “the Splendour of Divinity,” identifying it with the space of the salvific influence on a person, sanctified by Christ’s spousal love and called to develop an ethos based on this love.