bluuebunny/crossref_metadata_2025 huggingface dataset:
MECHANISMS IN ENDOCRINOLOGY: SGLT2 inhibitors: clinical benefits by restoration of normal diurnal metabolism?
Authors: Esterline Russell L , Vaag Allan , Oscarsson Jan , Vora Jiten
Published: January 2018

Type 2 diabetes (T2D) is associated with inhibition of autophagic and lysosomal housekeeping processes that detrimentally affect key organ functioning; a process likely to be exacerbated by conventional insulin-driven anabolic therapies. We propose that the cardio-renal benefits demonstrated with sodium–glucose cotransporter-2 inhibitor (SGLT2i) treatment in T2D partly may be explained by their ability to drive consistent, overnight periods of increased catabolism brought about by constant glucosuria. Key steps driving this catabolic mechanism include: a raised glucagon/insulin ratio initially depleting glycogen in the liver and ultimately activating gluconeogenesis utilizing circulating amino acids (AAs); a general fuel switch from glucose to free fatty acids (accompanied by a change in mitochondrial morphology from a fission to a sustained fusion state driven by a decrease in AA levels); a decrease in circulating AAs and insulin driving inhibition of mammalian target of rapamycin complex 1 (mTORC1), which enhances autophagy/lysosomal degradation of dysfunctional organelles, eventually causing a change in mitochondrial morphology from a fission to a sustained fusion state. Resumption of eating in the morning restores anabolic biogenesis of new and fully functional organelles and proteins. Restoration of diurnal metabolic rhythms and flexibility by SGLT2is may have therapeutic implications beyond those already demonstrated for the cardio-renal axis and may therefore affect other non-diabetes disease states.
HAPT2D: high accuracy of prediction of T2D with a model combining basic and advanced data depending on availability
Authors: Di Camillo Barbara , Hakaste Liisa , Sambo Francesco , Gabriel Rafael , Kravic Jasmina , Isomaa Bo , Tuomilehto Jaakko , Alonso Margarita , Longato Enrico , Facchinetti Andrea , Groop Leif C , Cobelli Claudio , Tuomi Tiinamaija
Published: January 2018

Objective

Type 2 diabetes arises from the interaction of physiological and lifestyle risk factors. Our objective was to develop a model for predicting the risk of T2D, which could use various amounts of background information.

Research design and methods

We trained a survival analysis model on 8483 people from three large Finnish and Spanish data sets, to predict the time until incident T2D. All studies included anthropometric data, fasting laboratory values, an oral glucose tolerance test (OGTT) and information on co-morbidities and lifestyle habits. The variables were grouped into three sets reflecting different degrees of information availability. Scenario 1 included background and anthropometric information; Scenario 2 added routine laboratory tests; Scenario 3 also added results from an OGTT. Predictive performance of these models was compared with FINDRISC and Framingham risk scores.

Results

The three models predicted T2D risk with an average integrated area under the ROC curve equal to 0.83, 0.87 and 0.90, respectively, compared with 0.80 and 0.75 obtained using the FINDRISC and Framingham risk scores. The results were validated on two independent cohorts. Glucose values and particularly 2-h glucose during OGTT (2h-PG) had highest predictive value. Smoking, marital and professional status, waist circumference, blood pressure, age and gender were also predictive.

Conclusions

Our models provide an estimation of patient’s risk over time and outweigh FINDRISC and Framingham traditional scores for prediction of T2D risk. Of note, the models developed in Scenarios 1 and 2, only exploited variables easily available at general patient visits.
Increasing frequency of combination medical therapy in the treatment of acromegaly with the GH receptor antagonist pegvisomant
Authors: Strasburger Christian J , Mattsson Anders , Wilton Patrick , Aydin Ferah , Hey-Hadavi Judith , Biller Beverly M K
Published: January 2018

Pegvisomant monotherapy is effective and safe in treatment of acromegaly. However, some clinicians combine pegvisomant with somatostatin analogues (SSA) or dopamine agonist (DA). In this analysis of ACROSTUDY, a long-term non-interventional study, the use of combination regimens was evaluated. Based on their baseline treatment, 2043 patients were retrospectively categorized as: long-acting SSA combined with pegvisomant, ‘Combo SSA’ 768 patients (38%); DA combined with pegvisomant, ‘Combo DA’ 123 (6%); pegvisomant monotherapy, ‘Peg mono’ 1128 (55%). Treatment patterns changed over the 10-year period, with recent patients more likely to receive any combination (20% in 2003 vs 54% in 2012). Combo SSA use varied widely among countries from 22% to 78%. Exposure periods of the three treatment modalities were defined from pegvisomant start until the last visit in ACROSTUDY; patients could switch treatment categories. At year 4, IGF-I was normal in 62% of Combo SSA, 63% of Combo DA and 65% of Peg mono groups. Pegvisomant was initiated as daily injections in 94% of patients in the Peg mono group, 66% of Combo SSA and 91% of Combo DA patients. During 6169 years of treatment exposure, 3424 adverse events (AEs) were reported in 946 (51%) patients, of which 617 (18%) were serious and 401 (12%) were considered treatment related. The reported incidence of serious AEs and treatment-related non-serious AEs were similar among the three treatment modalities. This analysis describes real-world clinical care and shows favorable efficacy and safety for Peg mono and combinations. Novel findings include an increased use of combination therapy over time and variability in treatment modalities between countries.
Systematic Functional Characterization of Human 21st Chromosome Orthologs inCaenorhabditis elegans
Authors: Nordquist Sarah K , Smith Sofia R , Pierce Jonathan T
Published: January 2018

Individuals with Down syndrome have neurological and muscle impairments due to an additional copy of the human 21st chromosome (HSA21). Only a few of ∼200 HSA21 genes encoding proteins have been linked to specific Down syndrome phenotypes, while the remainder are understudied. To identify poorly characterized HSA21 genes required for nervous system function, we studied behavioral phenotypes caused by loss-of-function mutations in conserved HSA21 orthologs in the nematode Caenorhabditis elegans. We identified 10 HSA21 orthologs that are required for neuromuscular behaviors: cle-1 (COL18A1), cysl-2 (CBS), dnsn-1 (DONSON), eva-1 (EVA1C), mtq-2 (N6ATM1), ncam-1 (NCAM2), pad-2 (POFUT2), pdxk-1 (PDXK), rnt-1 (RUNX1), and unc-26 (SYNJ1). We also found that three of these genes are required for normal release of the neurotransmitter acetylcholine. This includes a known synaptic gene unc-26 (SYNJ1), as well as uncharacterized genes pdxk-1 (PDXK) and mtq-2 (N6ATM1). As the first systematic functional analysis of HSA21 orthologs, this study may serve as a platform to understand genes that underlie phenotypes associated with Down syndrome.
Identification of Environmental Cues and Decision-Making Strategies of Residential Burglars
Authors: So-Yeon Park  , Kyung-Hoon Lee
Published: January 2018

In this study, as a preliminary study for a development of a residential burglars' target selection model, previous studies on residential burglars' target selection were reviewed and analyzed in terms of methods and purposes of research, and the implications for future research were suggested by integrating the results of the review. Firstly, it seems that the experimental research method has many advantages for developing the target selection model at the house level compared to using crime data and conducting interviews or questionnaires. Secondly, virtual reality can be used as an effective tool in the experiment, since it allows researchers to construct the experimental environment without any constraint and enables participants to be completely immersed. Thirdly, although researchers in the field of architecture tend to mainly focus on deriving environmental cues that influence the decision of the burglar, decision-making strategies used by burglars when selecting targets should also be identified to develop a comprehensive model of burglars' target selection. Finally, considering the cognitive process of residential burglar, several research questions can be derived (i.e. ‘What environmental cues do burglars consider when evaluating each environmental attribute?’, ‘What decision-making strategy do burglars use to evaluate each environmental attribute?’, and ‘What decision-making strategy do burglars use to make a decision on whether or not to commit burglary?’).
Formation of oil and gas reservoirs in deep water areas of the South Caspian Depression
Authors: Ogly Gahramanov Gahraman Nariman
Published: January 2018

The aim of the article is the identification and characterization of complex factors acting simultaneously on forming a large-sized reservoirs in the deep South Caspian Basin, as well as the formation of a model based on a combination of causing the formation of hydrocarbon deposits synchronously occurring natural processes. The article comments on reasons for high layer pressures existing in the fields located in the South Caspian Depression (SCD), studies impacting factors and develops a methodical estimation on this basis. The tectonic factor and density-barometric model can become the main criterion for selection of priority projects for exploration, site selection for drilling and to accommodate exploration and production wells. Obtained results allow conducting effective studies of the exploration and development of oil and gas condensate fields in the SCD area.
Direct Shear Test of Unsaturated Soil
Authors: He Peng , Sun Liuying , Wang Zhen
Published: January 2018

The present study focuses on some tentative laboratory tests using a newly-constructed modified direct shear test apparatus. The single-stage and multistage direct shear tests were performed to determine the shear rate and test scheme of unsaturated shear test. Shear strength parameters of unsaturated soil in different conditions are obtained and the tests indicate good agreement with typical theories of unsaturated soil, the nonlinear matric suction failure envelope is determined. Some shear strength equations are also fitted through the experimental results.
Paisajes en el cine irlandés. El ejemplo de La Hija de Ryan
Authors: Domínguez Belloso Abraham
Published: January 2018

El artículo reflexiona sobre el paisaje en el cine que tiene como escenario natural Irlanda y su geografía física y humana, mostrando la carga simbólica y emocional que posee y que determina su propio lenguaje. Se aborda la experiencia paisajística en la película La hija de Ryan (Ryan´s Daughter, David Lean, 1970), en la cual, el paisaje capaz de la trasformación humana y de los designios de los protagonistas en un sentimiento propio del movimiento romántico donde la naturaleza y el hombre son parte de un mismo cosmos que se va espiritualizando. Será, además, un paisaje en constante movimiento que se explicará mediante los símbolos y las metáforas visuales que tanto le gustaban a su director David Lean, planteando la oscuridad del hombre frente a la luz del entorno y huyendo de lo épico, dejando paso a lo dramático y permitiendo que el espectador pueda descubrir por sí mismo lo que aparece ante sus ojos.
Antecedentes de los Estudios Visuales y la Historia del Arte: los aportes a la Teoría Visual
Authors: Montero Rodríguez Daniel
Published: January 2018

El presente trabajo consiste en un acercamiento general al campo de la Teoría Visual, a partir del análisis de las nuevas metodologías propuestas por los Estudios Visuales, en la cultura visual de las sociedades contemporáneas. En primer lugar, se abordan las coincidencias y las divergencias entre la Historia del Arte y los Estudios Visuales, como propuestas epistemológicas para el estudio de la imagen-documento. Por otra parte, se analiza el debate que estas posiciones teóricas generan, así como la relación de ambas dentro del campo de la Teoría Visual.
The Globe of the Salvator Mundi between Cosmography and Theology
Authors: Rappenglück Barbara
Published: January 2018

This paper focuses on the globe in depictions of the Salvator Mundi (Redeemer of the World), in which Christ is shown blessing with His right hand and holding the globe of the world in His left hand. From the end of the fifteenth to the start of the seventeenth century these globes show a remarkable diversity which is not observed either earlier or later, and the current paper relates this to the vibrant cosmological, astronomical and also geographical discussions and discoveries of the period. Also discussed is the influence that the theological topic of salvation may have had on the artistic appropriation of cosmographical ideas and their adaption in depictions of the Salvator Mundi’s globe.
Comparison of open and closed book test for admission in medical school
Authors: Cade Charline , Riou Jérémie , Richard Isabelle , Passirani Catherine , Letertre Elisabeth , Fayolle Anne-Victoire
Published: January 2018

This article was migrated. The article was marked as recommended. Introduction: Students' learning methods are highly influenced by the type of evaluation. Consequently, evaluation is a deciding step in the learning process. Multiple Choice Format Tests (MCQs) are almost exclusive in the admission to Health studies. PluriPASS suggests an educational reform of Health studies. This research aims at analyzing docimological features of Open-book Multiple Choice Format tests (OBT) compared to other usual tests used during the first year in Health studies curriculum (CC). Methods: This educational research took place during PluriPASS year in Health studies curriculum at Angers University, during the academic period 2015-2016. The optional course « Disability and Health » (DH) was partly assessed by open-book tests with complex wording, requiring careful thought from students. Results: Out of the 1161 students enrolled in first year curriculum, 190 have chosen the DH. For the students who followed the DH, the CC and OBT distributions are respectively a Skewness score at -0.11 and -0.12 and a Kurtosis score at -0.9 and -0.22. Bland Altman test or Deming method demonstrate a concordance between both method. Conclusion: Distribution characteristics of OBT are satisfactory and allow to consider introducing this method with the objective of promoting reflection and depth learning.
Prospective Evaluation of the Impact of the 21-Gene Recurrence Score Assay on Adjuvant Treatment Decisions for Women with Node-Positive Breast Cancer in Ontario, Canada
Authors: Torres Sofia , Trudeau Maureen , Gandhi Sonal , Warner Ellen , Verma Sunil , Pritchard Kathleen I. , Petrella Teresa , Hew-Shue Mark , Chao Calvin , Eisen Andrea
Published: January 2018

Background

The 21-gene Recurrence Score (RS) assay is only reimbursed in Ontario for node-negative and micrometastatic node-positive (N+) early-stage breast cancer (EBC). We carried out a prospective study to evaluate the impact of the assay on treatment decisions for women with N+ EBC.

Subjects, Materials, and Methods

Women with estrogen receptor-positive, human epidermal growth receptor 2-negative EBC and one to three positive axillary lymph nodes, who were candidates for adjuvant chemotherapy in addition to hormonal treatment, but in whom the benefit of chemotherapy was uncertain, were eligible. The primary objective was to characterize how the results of the RS assay affected physicians’ recommendations for adjuvant chemotherapy. Secondary objectives were to characterize changes in the physicians’ and patients’ level of confidence in treatment recommendations, to determine whether the results of the RS assay affected patients’ treatment preferences, and to determine the final treatment administered.

Results

Seventy-two patients were recruited; the mean age was 61. RS was <18 in 55%, between 18 and 30 in 36%, and ≥31 in 9% of patients. Treatment recommendations changed in 36% of all evaluable patients. The most significant change was in the group with a low RS. Physicians’ and patients’ confidence in treatment recommendations increased in 49% and 54% of cases, respectively. Upfront chemotherapy was recommended to 79% of patients before the assay; 42% ultimately received chemotherapy.

Conclusion

The RS assay resulted in a substantial decrease in the number of patients who received chemotherapy and in an increase in physicians’ and patients’ confidence in the adjuvant treatment recommendations.

Implications for Practice

This is the first decision impact study to include exclusively women with ER-positive, HER2-negative, early-stage breast cancer with 1–3 positive lymph nodes, a population typically treated with adjuvant chemotherapy. This study provides evidence that, in these patients, the Oncotype Dx Recurrence Score assay influences systemic treatment decisions. Most of the changes in treatment recommendation resulted in withdrawal of chemotherapy or change in recommendation from a chemotherapy regimen with anthracyclines to a taxane-only regimen. If prospective studies confirm that these decisions result in good outcomes, a reduction in the use of chemotherapy might result in pharmacoeconomic savings.
Do Androids Dream of Asylum? The Blade Runner Films (1982, 2017) and Fear of the 'Other'
Authors: Kathrani Paresh
Published: January 2018

One of the predominant themes of both Blade Runner movies from 1982 and 2017 is the fear of the ‘other’. At the same time as the replicants represent the most obvious other, both films’ enduring genius lie in how they use features like their soundtracks, images and storylines to make the other resonate. Asylum seekers and refugees too are often perceived as others and this film review uses international refugee law as a framework to explore some of the critical themes that arise in both the movies. It argues that there are common issues that underpin the treatment of persecuted people and replicants, especially stemming from otherness, and international refugee law is a good framework to explore these issues.
Comportamento diário ao longo do período de alimentação do primeiro estágio do sistema francês de wetland vertical, em termos de remoção de matéria orgânica e amônia
Authors: Trein Camila Maria , Zumalacarregui Jorge Alejandro García , Sperling Marcos Von
Published: January 2018

O objetivo desse trabalho foi avaliar o comportamento do potencial de nitrificação e remoção de matéria orgânica no primeiro estágio de um wetland construído vertical - sistema francês (WCV-SF), operando com dois leitos em paralelo, cada um com 7 dias de alimentação e 7 dias de repouso, sob condições climáticas brasileiras. A estação de tratamento avaliada está localizada no Centro de Pesquisa e Treinamento em Saneamento (CePTS) da Universidade Federal de Minas Gerais e Companhia de Saneamento de Minas Gerais, UFMG/COPASA, na cidade de Belo Horizonte, Brasil. Complementando o monitoramento rotineiro praticado há anos neste sistema, efetuou-se um monitoramento intensivo da qualidade do afluente e do efluente do WCV-SF durante uma semana, por meio de análises físico-químicas, através de coletas simples diárias nos tempos de 5, 10, 15, 20, 30, 40 e 50 minutos depois do início de uma batelada. Durante o período de monitoramento foi possível observar a eficiência dessa etapa associada à decomposição da matéria orgânica, permanecendo satisfatória mesmo em períodos de sobrecarga. Com concentrações positivas de oxigênio no efluente, o desempenho do sistema ao longo dos 7 dias de alimentação apresentou eficiência média de remoção e 69% para DQO. Em termos de nitrogênio, a eficiência de remoção de N-NH4+ foi de 58% e a produção de N-NO3- diminuiu com o avanço dos dias de alimentação, reportando 20 mg L-1 no 2º dia e 11 mg L-1 no último. De uma forma geral, apesar de ter apenas duas unidades em paralelo, o sistema mostrou boa capacidade de receber esgoto bruto por um período de tempo maior de alimentação, reforçando os resultados obtidos no monitoramento rotineiro.
Sistema integrado de tratamento de efluentes sanitários com reatores anaeróbios sequenciais em batelada e wetlands construídos de fluxos alternados
Authors: Colares Gustavo Stolzenberg , Da Silva Fagner Pereira , Celente Gleison De Souza , Radtke Julia Fernanda , Machado Ênio Leandro
Published: January 2018

A concepção de um sistema integrado de wetlands construídos (WCs), de diferentes configurações, foi desenvolvida neste trabalho visando melhorias para remoção de nitrogênio e fósforo de efluentes de águas negras e amarelas, bem como da não utilização de suporte fixo para plantio das mudas de Hymenachne grumosa em parte do sistema. Canos de PVC foram utilizados em parte para montagem do sistema nas unidades de wetlands construídos flutuantes de fluxo horizontal + flutuantes de fluxo alternado + de fluxo vertical. No último estágio foram aplicadas britas de números 1 e 2 para o sistema suporte. Os estudos foram feitos no campus da Universidade de Santa Cruz do Sul - UNISC, RS. As taxas de aplicação de Carbono Orgânico Total (COT), nitrogênio amoniacal e fósforo solúvel foram controladas para não ultrapassar respectivamente os limites de 26, 1,2 e 0,2 g m-1 dia-1 nos três sistemas integrados, considerando tempo de detenção de 7 dias para cada compartimento. As disposições das macrófitas foram de 24 até 32 mudas m-2, sendo que lentilhas (Lemna sp.) e alfaces d’água (Pistia stratiotes) foram utilizadas para controle de espaços em aberto na superfície do líquido nas configurações flutuante de fluxo horizontal (WCFFH) e flutuante de fluxo horizontal alternado (WCFFA). Os resultados revelaram faixas de reduções da carga poluente após os WCs de 50-72% para o COT; de 77,7-93,7% para N-NH3 e de 88,8-94,7% para fósforo solúvel. O desenvolvimento do sistema radicular das macrófitas dos sistemas flutuantes ainda não atingiu a potencial plenitude de até 40 cm, sendo, portanto, possíveis melhores resultados com o decorrer dos estudos.
The Right to Just Administrative Action in the Context of Suspending the Payment of Disputed Tax
Authors: De Lange Silke , Van Wyk Danielle
Published: January 2018

Section 164(3) of the Tax Administration Act 28 of 2011 (hereafter TAA) provides a senior South African Revenue Service official (hereafter, respectively, SARS and senior SARS official) with discretionary powers to suspend the payment of disputed tax or a portion thereof, having regard to relevant factors, if the taxpayer intends to dispute the liability to pay such tax. Exercising a discretion in terms of section 164(3) of the TAA constitutes administrative action. Section 33(1) of the Constitution of the Republic of South Africa, 1996 (hereafter Constitution) grants everyone the right to just administrative action that is lawful, reasonable and procedurally fair and the Promotion of Administrative Action Act 3 of 2000 (hereafter PAJA) was promulgated to give effect to this right. The objective of this article is to apply the right to just administrative action to the manner in which the discretion in terms of section 164(3) of the TAA is exercised. This is achieved by adopting an explanatory research approach and performing a literature review of the discretion process in terms of section 164(3) of the TAA and the constitutional obligations in terms of section 33 of the Constitution as given effect to in PAJA. As the discretion exercised by the senior SARS official is influenced directly by the right to just administrative action, it should be exercised in a lawful, reasonable and procedurally fair manner to ensure compliance with the Constitution and the PAJA. For the discretion to be exercised in a lawful manner, the senior SARS official must at least be authorised to exercise the discretion in terms of the TAA and comply with the procedures and conditions stated in section 164(3) of the TAA. For the decision to be considered reasonable, the decision must be, at the minimum, rational and proportional, and to ensure that the discretion is exercised in a procedurally fair manner, SARS should comply with at least the relevant compulsory elements in terms of section 3(2)(b) of PAJA. A decision in terms of section 164(3) of the TAA which fails to meet the requirements of lawfulness, reasonableness and/or procedural fairness will be subject to review on several grounds listed in section 6(2) of PAJA.
A Critical Analysis of the New Equal Pay Provisions Relating to Atypical Employees in Sections 198A-198D of the LRA: Important Lessons from the United Kingdom
Authors: Ebrahim Shamier
Published: January 2018

The Employment Equity Act 55 of 1998 (EEA) is the main piece of legislation which seeks to achieve equity in the workplace by redressing unfair discrimination. Unequal pay for equal work and work of equal value are specific forms of discrimination which are dealt with in the EEA. The EEA provisions dealing with pay discrimination applies to all employees in the workplace which includes atypical employees. An employee experiencing pay discrimination in the workplace would thus use the EEA to institute an equal pay claim. This, however, has changed since the introduction of sections 198A-198D of the Labour Relations Act 66 of 1995 (LRA) which provides equal pay protection for atypical employees earning below the threshold of R205 433.30 and subject to certain other conditions. Sections 198A-198D of the LRA only deals with equal pay for the same or similar work. The sections do not deal with equal pay for work of equal value. This equal pay protection in the LRA is unique as the redress of unfair discrimination is not one of the purposes of the LRA.

The purpose of this article is to analyse the equal pay provisions as set out in sections 198A-198D of the LRA in order to ascertain the ambit of the protection offered by the sections, the limitations thereof and the dispute resolution procedure which should be followed. A brief comparative study with the law regulating equal pay for atypical employees in the United Kingdom will be undertaken in order to learn lessons for the equal pay legal framework in the LRA. International labour law will also be referred to.
Grafikus felület készítése épületek energiafogyasztásának szimulációs vizsgálatához
Authors: Tyukodi Zsolt , Sarvajcz-Bánóczy Emese , Husi Géza
Published: January 2018

Ezen kutatás keretein belül egy lakóépület energetikai szimulációja történt EnergyPlus programmal. Az épületre több változat is készíthető egy SciLab alkalmazással, mellyel az EPISCOPE program keretein belül készített Lakóépület tipológia Magyarországon kiadványban javasolt felújítási módosítások szerint változtathatjuk az épületszerkezetet. Ezen kívül további alkalmazások készültek a szimulációs eredmények megjelenítésére és energetikai tanúsítványhoz szükséges adatok számítására.
Pneumatikus megfogóval szerelt többtengelyes manipulátor irányítása PLC -vel
Authors: Nagy Ádám , Tóth János , Husi Géza
Published: January 2018

Projekt feladat során a többtengelyes manipulátor működése lett megvizsgálva. A feladat megoldása Bosch PLC (Programmable Logic Control) HMI (Human Machine Interface) felhasználásával, ST (Structured Text) programozási nyelv segítségével. A manipulátor egy gyártási folyamatban történő alkatrész mozgást valósít meg.
Valeological Potential of Home Attachment in Adults
Authors: Reznichenko S.I.
Published: January 2018

The article focuses on the role of subject-environment interactions, namely, human relationship with home environment, in maintaining mental health of a person. As a key construct that reflects personal preferences and love toward home it is proposed to consider the phenomenon of home attachment. Until now, the relationship between home attachment and psychological health and, moreover, the analysis of these relationships in the context of life course has been the subject of theoretical constructions, that prove the benefit of their empirical research. Home attachment was measured with the author’s same name questionnaire (Reznichenko et al., 2016). There were also measured mental health and its components: psychological well-being (using the Warwick-Edinburgh Mental Wellbeing Scale of R. Tennant and colleagues), a sense of connectedness (Sense of Coherence scale developed by A. Antonovsky) and authenticity (the Authenticity Scale by A. Wood, et al.). Adult respondents (N=203; age range 18-60 years; Mage=33.7; SDage=7.2) were participated in the study; the sample was divided into three age groups: youth age, early adulthood and middle adulthood. The obtained results allowed concluding that home attachment is a resource of mental health, especially in maintaining a sense of coherence and psychological well-being. It was found that the relationship between home attachment and psychological health is age-specific: the strongest correlations are observed in youth, they become insignificant in early adulthood, and in middle adulthood they become significant again. The results are discussed in the context of life and age-related problems of personality development.
The Role of Conscious Self-Regulation in Realization of Cognitive and Personal Resources in a Child with Developmental Delay
Authors: Babkina N.V.
Published: January 2018

The article is devoted to a problem of cognitive and personal development of children with developmental delay. Investigation aimed on exploration of self-regulation in first-grade children with developmental delay in comparison with normally developing peers is presented. Disorders in conscious regulation of cognitive activity, which hamper their assimilation of learning materials and adaptation to school, where identified. A complex curriculum on forming regulatory sphere, which includes psychological support and special organization of the educational environment, has been developed and tested. Efficiency of the described curriculum is confirmed by fixed improvements of data on randomness in children of experimental group and their forthcoming towards normally developing peers. The results of the experimental data found their reflection in Federal state educational standard for children with disabilities where work on developing random regulation of activity and behavior has been included into contents of teaching for the first time as obligatory approach.
The Specificity of the Cognitive Representations of Time in Elderly
Authors: Melehin A. , Kireeva Z.A.
Published: January 2018

The article is devoted to research features of verbal and nonverbal cognitive representations of time as a component of the cognitive model of time perception in elderly and senile age. The basis of the relationship to time is a cognitive model of time perception, consisting of the cognitive representation of time. Cognitive model of time involved in the process of shaping a person's entire picture of the world and understanding their place in it. The results of the study allow us to describe the specifics of the knowing and experiencing of time. Representation of time in elderly and senile are characterized by the description of the time through the prism of the life, units of measuring time, as well as metaphorical images describing the properties and rate of flow of time. Time, in later ages represented as a finite resource that is accompanied by a feeling of scarcity, time pressure and accelerated subjective time.
Methodological and Methodical Issues in Clinical Studies Concerning Values
Authors: Leontyeva E.M.
Published: January 2018

The article presents the purchase to studying value systems in various sciences; psychology, philosophy. The paper describes methodological difficulties in clinical studies of values. The first difficulty; an unspoken conviction held by clinicians that psychologically ill patients are not in possession of values whatsoever, or that there is a difference expressed in the production of certain value clusters. The second difficulty is a lack of normative values and the influence of postmodern world views on psychological practice. The article considers a need for reflections on internal value systems. Thereby the contemporary clinical study of value systems, should lead to solutions to the aforementioned problems. For a holistic study of value systems it is necessary to create special experimental conditions to a reflection and understanding of One's Own value systems by the subjects of the study. The article proposes a set of adequate and necessary requirements for patho-psychological experiments in the field of value thought processes of patients with a diagnosis of schizophrenia. As an example of such a study the author shows a detailed interview following a modelled value based dialogue and the authors methodology of ‘value classification’. Presented is the interview structure, a set of used values, instructions given to participants, and supplementary questions.
What the Pokemon Go have study adolescents for?
Authors: Khlomov K.D. , Davydov D.
Published: January 2018

The paper reports the results of the research on the adolescents – Pokemon Go players. The hypotheses towards the role of the games with virtual and augmented reality within the modern society presented in the scientific literature are discussed. The aim of this research was to check the link between personal characteristics, the social situation factors (e.g. family context), young men images about him or herself, and meaning and personal value of the game. The results of the structured interviews with 44 adolescents playing Pokemon Go on the street are given; the players’ representations towards themselves, their social environment, and the game are discovered. The conclusions about the meaning of the virtual, geographic, and social realities integration and social and family environment influence on the game involvement are made. The psychological mechanisms of the involvement into the game and the role of the social and family environment are discussed. In this article was made the conclusions about the role of virtual, geographic, social reality integration, social and family role, and psychological mechanism to be involved in the game. Subjective space transformation and the changes in everyday city landscape meanings conditioned by the game are discussed. The game allows the adolescents and youth to see the reality out of the everyday routine.
The Spiritual Space of Modern Education: Problems, Theory, Practice. The Interregional Conference in Memory of A. D. Chervyakov
Authors: Serova O.E. , Guseva E.P.
Published: January 2018

The authors provided information on the first interregional conference of scientific and pedagogical community of the Yaroslavl region dedicated to the memory of the Psychological Institute employee A.D.Chervyakov - scholar, historian of psychology, methodology and organizer of work on the formation of spiritual and moral content of training courses for children and teenagers. In the plenary session speakers invited to discuss a wide range of General methodological issues: the moral lessons of the creative heritage of Russian ascetics, scholars and teachers; the importance of the Orthodox culture in historical educational research context; the practice of the study of old Russian literature as a factor in the spiritual development of students; studying in school and University language of the icon as the basis of spiritually-moral education of a person; moral criteria for the development of the individual student in the modern education; the spiritual foundations of psychological perspectives; ethical and moral standards in the work of the teacher. Discussion at the round table "Youth subculture: tradition and deviation, moral and psychological-pedagogical problems" turned on: a subculture as a tool of socialization and moral formation adolescents; antisocial practices in subcultural spaces; the moral and psychological degradation as a consequence of aggressive subcultural associations; the way to build a dialogue of generations in the modern educational space; the family as an important resource for the confrontation of anti-social effects of youth subcultures; the spiritual and moral traditions of the Yaroslavl region as a means to counter the influence of destructive youth subcultures.
INTENSITAS PERDAGANGAN INTRA-REGIONAL DALAM ASEAN-3 (Indonesia, Malaysia, dan Thailand)
Authors: Adi Lumadya
Published: January 2018

ABSTRACT The purpose of this paper is to test the intra-regional trade in the ASEAN-3 includes: Indonesia, Malaysia and Thailand. Analysis tool is: Intensity of intra-regional trade. The advantage of this analysis tool is a country is known to include density of intra-export or density of intra-import: if positive then the country belong to the density of intra-export; and if negative, including the density of intra-import. Study in period 2000-2014. Based on the intensity of intra-regional trade: Indonesia, Malaysia, and Thailand has a coefficient equally negative meaning because all three are density of intra-import; The third country that has no comparative advantage. Indonesia, Malaysia, and Thailand have the same density intra-import commodity that must strive harder to improve efficiency.
PENGARUH RELIGITAS, KUALITAS LAYANAN DAN TRUST TERHADAP LOYALITAS NASABAH BANK SYARIAH DI KOTA BOGOR
Authors: Wahyoedi Soegeng , Winoto Hery
Published: January 2018

ABSTRACT The role of Islamic banking in the national economy becomes more strategic as the government is facing fiscal limitation in funding the development. The growth of Islamic banking, a bank managed by implementing the principles of Islamic law, has not been satisfactory. This can be examined by referring to the role of Islamic banking in national banking which is  till in the rate of less than 5 percent. This research aims to observe the influences of religiosity and service quality on trust and customer loyalty, as well as to observe the influence of trust on customer loyaltyof Islamic Bank in Bogor. By collecting 76 samples of Islamic bank customers in Bogor and utilizing structural equation modeling partial least square (SEM-PLS) as the technique of analysis, it is revealed that the aspects of religiosity and service quality are influential on loyalty if it is supported by trust. Meanwhile, the trust itself has a positive influence on loyalty. The finding implies that to increase the loyalty of Islamic bank customers, customer trust should be built.
Family presence during resuscitation: patient and family members’ preferences and attitudes
Authors: Pratiwi Indah D.
Published: January 2018

Background: This literature review presents a review of the available studies into family presence during resuscitation (FPDR) in the context of emergency department and critical care unit from the point of view of patients and family members. This literature review provides the background for understanding the debate about FPDR. The paper examines the state of current research on the topic and points out gaps in existing literature.Methods: A comprehensive search of OVID Nursing, Web of Science (Web of Knowledge), Elsevier, ProQuest and Google Scholar electronic search engine. Thematic analysis was used to extract themes from the 25 studies reviewed (quantitative, qualitative and mixed-methods studies), resulted in five major themes and five minor themes.Results: Five major themes from this literature review were: (1) patient and family members’ preferences; (2) perceived benefits of family presence during resuscitation; (3) perceiving family presence as a right; (4) the importance of a family facilitator; and (5) the involvement of decision making.Conclusions: This literature review has established the potentials of family presence during resuscitation to improve patient and family-centred care by helping and providing family members to manage and to adjust during traumatic circumstances.
De Vega annuloplasty versus ring annuloplasty for repair of functional tricuspid regurgitation
Authors: Alnawaiseh Khaled , Albkhoor Bashar , Alnaser Yanal , Aladwan Hayel , Ghanma Issa
Published: January 2018

Background: Tricuspid insufficiency (TI) is a functional insufficiency in most of the cases and associated with the dilatation of the annulus and remolding. Pulmonary hypertension and right ventricular volume overload due to chronic aortic or / and mitral valve disease in most of the time causes the functional tricuspid insufficiency. Despite the different techniques used to repair the tricuspid valve, the recurrent TR is still occurring in 20- 30 % of the patients and the development of late TR is an important complication of left heart surgery. Our study aims to compare the long-term outcome of ring annuloplasty with De Vega annnuloplasty in patients with secondary tricuspid regurgitation (TR).Methods: A retrospective study of 320 patients who underwent tricuspid valve repair surgery for secondary tricuspid regurgitation from January 2002 to December 2010 at Queen Alia Heart Institute (QAHI). Patients were divided into two groups, in group (1) (n=180) patients had an annuloplasty ring. Group (2) (n=140) patients had De Vega procedure (no ring). The procedures were performed in association with mitral valve surgery in 78% of patients, aortic valve surgery in 15% and combined aortic and mitral valve surgery in 7% of patients. TR grade, NYHA functional class and Pulmonary artery pressure were nearly similar and no significant preoperative difference between the two groups.Results: Echocardiographic and clinical follow up were done for all patients. The duration of procedure for both De Vega and ring annuloplasty were nearly similar. The overall survival in ring group at 5year was 83.9% versus 77.9% in De Vega group. Freedom from residual and recurrent TR, event free survival and long-term survival were significantly better in the ring group and also the tricuspid valve reoperation were less in the ring group.Conclusions: The implantation of annuloplasty ring results in lower incidence of residual or recurrent of tricuspid regurgitation, improved the event-free survival and long-term survival when compared with the sewing techniques such as De Vega.
Histopathological spectrum of neoplastic lesions of female reproductive system-a two-year experience in Eastern Nepal
Authors: Singh Mrinalini , Jha Krishna Kumar , Poudyal Prija , Kafle Santosh Upadhyay
Published: January 2018

Background: Neoplastic lesions of female reproductive system (FRS) consist majority of surgical cases. The aim of this study is to find out the frequency distribution of tumors occurring in FRS.Methods: This is a retrospective study carried out in Birat Medical College, situated in eastern Nepal. All formalin fixed surgical specimen of FRS from August 2015 to September 2017 were subjected for histopathology and examined under light microscopy. All neoplastic lesions were included, and non-neoplastic lesions were excluded from the study.Results: A total number of ninety (90) histopathological tissues representating various types of neoplastic lesion of FRS were studied. Out of which 6 (6.6%) tumors were from uterine cervix, (including 1 cervical leiomyoma and 5 squamous cell carcinoma cervix) 45(50%) tumors were from uterine body, (all leiomyoma) 20 (22.2%) tumors were from ovary (including 9 mature teratoma, 1 immature teratoma, 6 mucinous cystadenoma and 4 cases of serous cystadenoma) and 19 (21.2%) tumors were from breast (including 16 fibroadenoma, 1 lactational adenoma, 2 infiltrating ductal carcinoma and 1 comedo carcinoma). Majority 81(90%) were benign and 9 (10%) were malignant. Most common benign tumor was leiomyoma of uterine body and most common malignant tumor was squamous cell carcinoma of uterine cervix both commonly occurring in the age group of 41-50 years.Conclusions: Benign tumor, leiomyoma is the common tumor occurring in FRS. Carcinoma of the cervix is the common malignant tumor.
Patch testing in hand eczema: a cross-sectional study from a teaching hospital of North India
Authors: Qayoom Seema , Rather Suhail R. , Khan Kafeel
Published: January 2018

Background: Hand eczema is a common dermatological disorder in different occupational groups with multifactorial etiology. Patch Testing serves as an important tool for identifying responsible allergens.Methods: The study was conducted in the Department of Dermatology, SKIMS-MCH, Srinagar for duration of one year from June 2016 to June 2017. Patients of either gender with hand eczema, aged 18 years and above, presenting to outpatient department were enrolled in the study. After taking informed written consent from patients, a detailed history was taken, and clinical examination was performed on first visit. Patch testing with Indian Standard Series was performed a fortnight after complete resolution of signs and symptoms of eczema and after complete withdrawal of the drugs.Results: Out of 116 patients 60 (51.7%) were males and 56 (48.3%) were females. Male to female ratio was 1.07:1. Mean age of presentation of females was 35.42±12.52years and of males was 49.2±10.01years. The commonest allergen was Nickel sulphate (23.2%) followed by Potassium dichromate (15.1%). Nickel sulphate was most common allergen in females while Cobalt sulphate and Paraphenylene diamine were most common allergens in males. House wives (36.2%) and farmers (11.2%) were occupations with high frequency of hand eczema.Conclusions: Patch testing in clinically diagnosed cases of hand eczema can play a vital role in not just the confirmation of the label but can also reduce the socio-economic burden on such patients.
To study the association of high sensitivity C-reactive protein with metabolic syndrome
Authors: Saini Vinod , Gupta Abhishek , Arora Mayank , Virmani S. K.
Published: January 2018

Background: Metabolic Syndrome is a constellation of dyslipidemia (elevated triglycerides, low high-density lipoproteins (HDL)), elevation of arterial blood pressure (BP), dysregulated glucose homeostasis, and increased abdominal obesity.Methods: We studied the association of high sensitivity C-reactive protein with metabolic syndrome by case-control method in our tertiary care hospital in West U.P.Results: The mean age of cases and controls was 52.6 ± 7.7 and 51.4±7.0 years, respectively. There were 25 (50%) male and 25 (50%) female in case groups, and 27 (54%) males and 23 (46%) females in control group. Our analysis revelaed that there was a significant association between hs-CRP and the central obesity when compared in case-control group (3.57 vs 0.96 mg/L) (p value <0.001). There was no significant association between hs-CRP and high triglycerides, hypertension, diabetes, and reduced high density lipoprotein cholesterol.Conclusions: Raised hsCRP level can be considered as a surrogate marker of chronic inflammation in patients with metabolic syndrome.
Is yoga an effective modality of stress reduction within medical population; a qualitative study within MBBS students of BRD medical college, Gorakhpur
Authors: Tiwari Vikash K. , Singh Vinay , Kumar Devesh , Mittal Mahim , Asthana A. B.
Published: January 2018

Background: Stress is very common in medical professionals. Stress begins in the first year of medical school and increases with subsequent years of medical life. Stress decreases overall performance and had a multitude of health-related adverse effect. Yoga has been tried as a stress reduction technique in different populations. In present study yoga was performed in the 1st year MBBS students and impact on stress reduction was studied using PSS-10 stress scale.Methods: Study groups, yoga and control contained 26 and 27 subjects respectively. The yoga group practiced selected yogic asana, pranayama, and yoga nidra 1hour daily 6days a week for 3months. Control group kept in touch and allowed their usual activity as before. The PSS-10 scale used to measure the level of stress in both groups pre and post study.Results: There was a highly significant reduction in the PSS-10 Score (stress level) in the yoga group (P Value <0.0001) but there was no significant change in the PSS-10 Score of control group (P Value = 0.2930).Conclusions: Yoga is an effective modality of stress reduction technique in 1st year medical students. Therefore, yoga should be introduced as a part of the curricula in the first year of medical school. This may be taken as the 1st step in implantation of healthy lifestyle in future health care providers.