bluuebunny/crossref_metadata_2025 huggingface dataset:
From Offshore Operation to Onshore Simulator: Using Visualized Ethnographic Outcomes to Work with Systems Developers
Authors: Pan Yushan , Finken Sisse
Published: February 2018

This paper focuses on the process of translating insights from a Computer Supported Cooperative Work (CSCW)-based study, conducted on a vessel at sea, into a model that can assist systems developers working with simulators, which are used by vessel operators for training purposes on land. That is, the empirical study at sea brought about rich insights into cooperation, which is important for systems developers to know about and consider in their designs. In the paper, we establish a model that primarily consists of a ‘computational artifact’. The model is designed to support researchers working with systems developers. Drawing on marine examples, we focus on the translation process and investigate how the model serves to visualize work activities; how it addresses relations between technical and computational artifacts, as well as between functions in technical systems and functionalities in cooperative systems. In turn, we link design back to fieldwork studies.
Intrinsic Properties of tRNA Molecules as Deciphered via Bayesian Network and Distribution Divergence Analysis
Authors: Branciamore Sergio , Gogoshin Grigoriy , Di Giulio Massimo , Rodin Andrei
Published: February 2018

The identity/recognition of tRNAs, in the context of aminoacyl tRNA synthetases (and other molecules), is a complex phenomenon that has major implications ranging from the origins and evolution of translation machinery and genetic code to the evolution and speciation of tRNAs themselves to human mitochondrial diseases to artificial genetic code engineering. Deciphering it via laboratory experiments, however, is difficult and necessarily time- and resource-consuming. In this study, we propose a mathematically rigorous two-pronged in silico approach to identifying and classifying tRNA positions important for tRNA identity/recognition, rooted in machine learning and information-theoretic methodology. We apply Bayesian Network modeling to elucidate the structure of intra-tRNA-molecule relationships, and distribution divergence analysis to identify meaningful inter-molecule differences between various tRNA subclasses. We illustrate the complementary application of these two approaches using tRNA examples across the three domains of life, and identify and discuss important (informative) positions therein. In summary, we deliver to the tRNA research community a novel, comprehensive methodology for identifying the specific elements of interest in various tRNA molecules, which can be followed up by the corresponding experimental work and/or high-resolution position-specific statistical analyses.
Application of Polymerization Activator in the Course of Synthesis of N-Isopropylacrylamide Derivatives for Thermally Triggered Release of Naproxen Sodium
Authors: Gasztych Monika , Kotowska Anna , Musiał Witold
Published: February 2018

Poly-N-isopropylacrylamide (polyNIPA) is an extensively studied polymer in the field of controlled drug delivery. PolyNIPA contains carbonyl and amide groups along a hydrophobic chain. In an aqueous environment, crosslinked polyNIPA forms a gel characterized by a reversible volume phase transition temperature (VPTT), in response to changes in the external environment excited by the temperature factor. NIPA-based polymers were synthesized by a surfactant-free precipitation polymerization (SFPP) method at a temperature of 70 °C using the free radical initiator potassium persulfate (KPS) and at 35 °C using redox initiator system KPS with N,N,N’,N’-tetramethylethylenediamine (TEMED). The synthesized products were evaluated via dynamic light scattering (DLS), nuclear magnetic resonance (NMR) and Fourier-transform infrared spectroscopy (FTIR). The chemical structure, molecular mass, and hydrodynamic diameter of obtained particles, as well as the effects of synthesized polymers on the release of the active substance, naproxen sodium (NS), from hydroxypropyl methyl cellulose (HPMC)-based hydrogels were assessed. The use of the TEMED activator affected the particle size, as well as the release kinetics of NS. The insertion of TEMED into reactant mixtures may be applied to modify the release kinetics of NS from hydrogel preparations.
Effect of C and N Addition on Thermoelectric Properties of TiNiSn Half-Heusler Compounds
Authors: Dow Hwan , Kim Woo , Shin Weon
Published: February 2018

We investigated the thermoelectric properties of the ternary half-Heusler compound, TiNiSn, when introducing C and N. The addition of C or N to TiNiSn leads to an enhanced power factor and a decreasing lattice thermal conductivity by point defect phonon scattering. The thermoelectric performances of TiNiSn alloys are significantly improved by adding 1 at. % TiN, TiC, and figure of merit (ZT) values of 0.43 and 0.34, respectively, can be obtained at 723 K. This increase in thermoelectric performance is very helpful in the commercialization of thermoelectric power generation in the mid-temperature range.
The Influence of the Interlayer Distance on the Performance of Thermally Reduced Graphene Oxide Supercapacitors
Authors: Lin Jun-Hong
Published: February 2018

In this paper, cationic surfactant cetyltrimethylammonium bromide (CTAB) was employed to prevent the restack of the thermally reduce graphene oxide (TRG) sheets. A facile approach was demonstrated to effectively enlarge the interlayer distance of the TRG sheets through the ionic interaction between the intercalated CTAB and ionic liquids (ILs). The morphology of the composites and the interaction between the intercalated ionic species were systematically characterized by SEM, SAXS, XRD, TGA, and FTIR. In addition, the performance of the EDLC cells based on these TRG composites was evaluated. It was found that due to the increased interlayer distance (0.41 nm to 2.51 nm) that enlarges the accessible surface area for the IL electrolyte, the energy density of the cell can be significantly improved (23.1 Wh/kg to 62.5 Wh/kg).
Facile Preparation of Nano-Bi2MoO6/Diatomite Composite for Enhancing Photocatalytic Performance under Visible Light Irradiation
Authors: Cai Lu , Gong Jiuyan , Liu Jianshe , Zhang Hailong , Song Wendong , Ji Lili
Published: February 2018

In this work, a new nano-Bi2MoO6/diatomite composite photocatalyst was successfully synthesized by a facile solvothermal method. Scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and UV-vis diffuse reflection spectroscopy (DRS) were employed to investigate the morphology, crystal structure, and optical properties. It was shown that nanometer-scaled Bi2MoO6 crystals were well-deposited on the surface of Bi2MoO6/diatomite. The photocatalytic activity of the obtained samples was evaluated by the degradation of rhodamine B (RhB) under the visible light (λ > 420 nm) irradiation. Moreover, trapping experiments were performed to investigate the possible photocatalytic reaction mechanism. The results showed that the nano-Bi2MoO6/diatomite composite with the mass ratio of Bi2MoO6 to diatomaceous earth of 70% exhibited the highest activity, and the RhB degradation efficiency reached 97.6% within 60 min. The main active species were revealed to be h+ and•O2−. As a photocatalytic reactor, its recycling performance showed a good stability and reusability. This new composite photocatalyst material holds great promise in the engineering field for the environmental remediation.
Fully Solution-Processable Fabrication of Multi-Layered Circuits on a Flexible Substrate Using Laser Processing
Authors: Ji Seok , Choi Wonsuk , Kim Hoon-Young , Jeon Jin-Woo , Cho Sung-Hak , Chang Won
Published: February 2018

The development of printing technologies has enabled the realization of electric circuit fabrication on a flexible substrate. However, the current technique remains restricted to single-layer patterning. In this paper, we demonstrate a fully solution-processable patterning approach for multi-layer circuits using a combined method of laser sintering and ablation. Selective laser sintering of silver (Ag) nanoparticle-based ink is applied to make conductive patterns on a heat-sensitive substrate and insulating layer. The laser beam path and irradiation fluence are controlled to create circuit patterns for flexible electronics. Microvia drilling using femtosecond laser through the polyvinylphenol-film insulating layer by laser ablation, as well as sequential coating of Ag ink and laser sintering, achieves an interlayer interconnection between multi-layer circuits. The dimension of microvia is determined by a sophisticated adjustment of the laser focal position and intensity. Based on these methods, a flexible electronic circuit with chip-size-package light-emitting diodes was successfully fabricated and demonstrated to have functional operations.
Nanoparticle-Based Strategies to Treat Neuro-Inflammation
Authors: Poupot Rémy , Bergozza Dylan , Fruchon Séverine
Published: February 2018

Neuro-inflammation is a pivotal physio-pathological feature of brain disorders, including neurodegenerative diseases. As such, it is a relevant therapeutic target against which drugs have to be proposed. Targeting neuro-inflammation implies crossing the Blood-Brain Barrier (BBB) to reach the Central Nervous System (CNS). Engineered nanoparticles (ENPs) are promising candidates to carry and deliver drugs to the CNS by crossing the BBB. There are several strategies to design ENPs intended for crossing through the BBB. Herein, we first put nanotechnologies back in their historical context and introduce neuro-inflammation and its consequences in terms of public health. In a second part, we explain how ENPs can get access to the brain and review this area by highlighting recent papers in the field. Finally, after pointing out potential guidelines for preclinical studies involving ENPs, we conclude by opening the debate on the questions of nanosafety and toxicity of these ENPs and in particular on ecotoxicity related to regulatory issues and public concerns.
Free Vibration Analysis of Moderately Thick Orthotropic Functionally Graded Plates with General Boundary Restraints
Authors: Fu Yu , Yao Jianjun , Wan Zhenshuai , Zhao Gang
Published: February 2018

In this paper, a modified Fourier series method is presented for the free vibration of moderately thick orthotropic functionally graded plates with general boundary restraints based on the first-order shear deformation theory. Regardless of boundary restraints, displacements and rotations of each plate are described as an improved form of double Fourier cosine series and several closed-form auxiliary functions to eliminate all the boundary discontinuities and jumps. Exact solutions are obtained by the energy functions of the plates based on Rayleigh-Ritz method. The convergence and reliability of the current method and the corresponding theoretical formulations are verified by comparing the present results with those available in the literature, and numerous new results for orthotropic functionally graded (OFG) plates with general boundary restraints are presented. In addition, the effects of gradient index, volume fraction and geometric parameters on frequencies with general boundary restraints are illustrated.
Dichloroisocoumarins with Potential Anti-Inflammatory Activity from the Mangrove Endophytic Fungus Ascomycota sp. CYSK-4
Authors: Chen Yan , Liu Zhaoming , Liu Hongju , Pan Yahong , Li Jing , Liu Lan , She Zhigang
Published: February 2018

Three new isocoumarins—dichlorodiaportintone (1), desmethyldichlorodiaportintone (2) and desmethyldichlorodiaportinol (3)—as well as six known analogues (4–9) were isolated from the culture of the mangrove endophytic fungus Ascomycota sp. CYSK-4 from Pluchea indica. Their structures were elucidated by analysis of spectroscopic data. The absolute configuration of compounds 1 and 2 were determined by the modified Mosher’s method. Compound 2 showed significant anti-inflammatory activity by inhibiting the production of NO in LPS-induced RAW 264.7 cells with IC50 value of 15.8 μM, while compounds 1, 5, and 6 exhibited weak activities with IC50 values of 41.5, 33.6, and 67.2 μM, respectively. In addition, compounds 1, 5, and 6 showed antibacterial effects against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Klebsiella pneumoniae, and Acinetobacter calcoaceticus with the MIC values in the range of 25–50 μg·mL−1.
Exploring Interventions for Sleep Disorders in Adolescent Cannabis Users
Authors: Furer Tzvi , Nayak Komal , Shatkin Jess
Published: February 2018

This review summarizes the available literature on the intersection of adolescent cannabis use and sleep disturbances, along with interventions for adolescent cannabis users who suffer sleep impairments. Adolescents are susceptible to various sleep disorders, which are often exacerbated by the use of substances such as cannabis. The relationship between cannabis and sleep is bidirectional. Interventions to improve sleep impairments among adolescent cannabis users to date have demonstrated limited efficacy, although few studies indicating the benefits of behavioral interventions—such as Cognitive Behavior Therapy for Insomnia or Mindfulness Based Stress Reduction—appear promising in the treatment of sleep disorders, which are present for users of cannabis. Further research is necessary to elucidate the precise mechanisms by which cannabis use coexists with sleep impairments, along with effective interventions for those users who suffer sleep difficulties.
23rd International Symposium on Infections in the Critically Ill Patient
Authors: Artigas Antonio , Carlet Jean , Martin-Loeches Ignacio , Niederman Michael , Torres Antoni
Published: February 2018

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Assessment of Ductile, Brittle, and Fatigue Fractures of Metals Using Optical Coherence Tomography
Authors: Hutiu Gheorghe , Duma Virgil-Florin , Demian Dorin , Bradu Adrian , Podoleanu Adrian
Published: February 2018

Some forensic in situ investigations, such as those needed in transportation (for aviation, maritime, road, or rail accidents) or for parts working under harsh conditions (e.g., pipes or turbines) would benefit from a method/technique that distinguishes ductile from brittle fractures of metals—as material defects are one of the potential causes of incidents. Nowadays, the gold standard in material studies is represented by scanning electron microscopy (SEM). However, SEM instruments are large, expensive, time-consuming, and lab-based; hence, in situ measurements are impossible. To tackle these issues, we propose as an alternative, lower-cost, sufficiently high-resolution technique, Optical Coherence Tomography (OCT) to perform fracture analysis by obtaining the topography of metallic surfaces. Several metals have been considered in this study: low soft carbon steels, lamellar graphite cast iron, an antifriction alloy, high-quality rolled steel, stainless steel, and ductile cast iron. An in-house developed Swept Source (SS) OCT system, Master-Slave (MS) enhanced is used, and height profiles of the samples’ surfaces were generated. Two configurations were used: one where the dimension of the voxel was 1000 μm3 and a second one of 160 μm3—with a 10 μm and a 4 μm transversal resolution, respectively. These height profiles allowed for concluding that the carbon steel samples were subject to ductile fracture, while the cast iron and antifriction alloy samples were subjected to brittle fracture. The validation of OCT images has been made with SEM images obtained with a 4 nm resolution. Although the OCT images are of a much lower resolution than the SEM ones, we demonstrate that they are sufficiently good to obtain clear images of the grains of the metallic materials and thus to distinguish between ductile and brittle fractures—especially with the higher resolution MS/SS-OCT system. The investigation is finally extended to the most useful case of fatigue fracture of metals, and we demonstrate that OCT is able to replace SEM for such investigations as well.
Evaluation of Sulfonate-Based Collectors with Different Hydrophobic Tails for Flotation of Fluorite
Authors: Zheng Renji , Ren Zijie , Gao Huimin , Qian Yupeng
Published: February 2018

This investigation aims to demonstrate the effects of hydrophobic tails on the affinity and relevant flotation response of sulfonate-based collectors for fluorite. For this purpose, a series of alkyl sulfonates with different hydrophobic tails, namely sodium decanesulfonate (C10), sodium dodecylsulfate (C12), sodium hexadecanesulfonate (C16), and sodium dodecylbenzenesulfonate (C12B) were applied. The flotation tests showed that C12 and C12B had a better collecting performance than C10 and C16 at pH < 10, and the flotation recovery of fluorite was higher when adopting C12B as a collector compared with C12 with a strong base. The adsorption behaviors of collectors on the fluorite surface were studied through zeta potential, Fourier transform infrared (FTIR), and X-ray photoelectron spectroscopy (XPS) analyses. It was found that the affinity of alkyl sulfonates for fluorite was enhanced with the increase of the alkyl chain length from C10 to C16. The existence of phenyl in the hydrophobic tail of sulfonates could improve its activity for fluorite by reducing its surface tension. The abnormal phenomenon C16 with a high affinity for fluorite had a low collecting performance for fluorite mainly due to its overlong alkyl chain, resulting in low solubility in pulp, which restrained its interaction with fluorite. We concluded that C12B was the most applicable collector for fluorite among these reagents due to its high activity, high solubility, and low cost, which was further substantiated by calculating their molecular frontier orbital energy.
Bauerenol Acetate, the Pentacyclic Triterpenoid from Tabernaemontana longipes, is an Antitrypanosomal Agent
Authors: Carothers Simira , Nyamwihura Rogers , Collins Jasmine , Zhang Huaisheng , Park HaJeung , Setzer William , Ogungbe Ifedayo
Published: February 2018

The Latin American plant Tabernaemontana longipes was studied in this work as a potential source of antiparasitic agents. The chloroform extract of T. longipes leaves was separated into several fractions, and tested for antitrypanosomal activity. One of the fractions displayed significant growth inhibitory activity against Trypanosoma brucei. The active principle in the fraction was isolated, purified, and characterized by NMR and mass spectrometry. The antitrypanosomal agent in the CHCl3 extract of T. longipes leaves is the pentacyclic triterpenoid bauerenol acetate. A metabolite profiling assay suggest that the triterpenoid influences cholesterol metabolism. The molecular target(s) of bauerenol and its acetate, like many other antiparasitic pentacyclic triterpenoids is/are unknown, but they present privileged structural scaffolds that can be explored for structure-based activity optimization studies using phenotypic assays.
Structure–Activity Relationship of Xanthones as Inhibitors of Xanthine Oxidase
Authors: Zhou Ling-Yun , Peng Jia-Le , Wang Jun-Ming , Geng Yuan-Yuan , Zuo Zhi-Li , Hua Yan
Published: February 2018

Polygala plants contain a large number of xanthones with good physiological activities. In our previous work, 18 xanthones were isolated from Polygala crotalarioides. Extented study of the chemical composition of the other species Polygala sibirica led to the separation of two new xanthones—3-hydroxy-1,2,6,7,8-pentamethoxy xanthone (A) and 6-O-β-d-glucopyranosyl-1,7-dimethoxy xanthone (C)—together with 14 known xanthones. Among them, some xanthones have a certain xanthine oxidase (XO) inhibitory activity. Furthemore, 14 xanthones as XO inhibitors were selected to develop three-dimensional quantitative structure–activity relationship (3D-QSAR) using comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) models. The CoMFA model predicted a q2 value of 0.613 and an r2 value of 0.997. The best CoMSIA model predicted a q2 value of 0.608 and an r2 value of 0.997 based on a combination of steric, electrostatic, and hydrophobic effects. The analysis of the contour maps from each model provided insight into the structural requirements for the development of more active XO inhibitors.
Contribution of Polyphenol Oxidation, Chlorophyll and Vitamin C Degradation to the Blackening of Piper nigrum L.
Authors: Gu Fenglin , Huang Feifei , Wu Guiping , Zhu Hongying
Published: February 2018

Black pepper (Piper nigrum L.) is the most widely used spice in the world. Blackening is considered to be beneficial and important in the processing of black pepper because it contributes to its color and flavor. The purpose of this paper is to investigate polyphenol oxidation as well as the chlorophyll and vitamin C (VC) degradation in the blackening of Piper nigrum L. Black pepper was produced by four methods, and changes in polyphenols, chlorophyll and VC were studied by high performance liquid chromatography (HPLC) and ultraviolet-visible and visible (UV-Vis) spectrophotometry. The results show that polyphenol oxidase activity significantly decreased during the preparation of black pepper, and the concentrations of phenolic compounds, VC, and chlorophyll a and b also significantly decreased. Polyphenol oxidation and chlorophyll and VC degradation contribute to the blackening. A crude extract of phenolic compounds from black pepper was prepared by the system solvent method. The greater the polarity of the extraction solvent, the higher the extraction rates of the phenolic compounds and the total phenol content. Pepper phenolic compounds were analyzed by HPLC analysis.
Synthesis and Magnetic Properties of Stable Radical Derivatives Carrying a Phenylacetylene Unit
Authors: Miyashiro Shogo , Ishii Tomoaki , Miura Youhei , Yoshioka Naoki
Published: February 2018

A nitronyl nitroxide derivative, 2-phenylethynyl-4,4,5,5-tetramethyl-4,5-dihydro-1H-imidazol-1-oxyl-3-oxide (1), and two verdazyl derivatives carrying a phenylacetylene unit, 1,5-diphenyl-3-phenylethynyl-6-oxo-1,2,4,5-tetrazin-2-yl (2) and 1,5-diisopropyl-3-phenylethynyl-6-oxo-1,2,4,5-tetrazin-2-yl (3), were synthesized and their packing structures were studied by X-ray crystallographic analysis and magnetically characterized in the solid state. While 1 and 3 had an isolated doublet spin state, 2 formed an antiferromagnetically coupled pair (2J/kB = −118 K). Density functional theory (DFT) calculations reveal that the spin density polarized in the phenyl group decreases as the dihedral angle between the phenyl ring and radical plane increases.
Dietary Cholesterol Intake and Risk of Lung Cancer: A Meta-Analysis
Authors: Lin Xiaojing , Liu Lingli , Fu Youyun , Gao Jing , He Yunyun , Wu Yang , Lian Xuemei
Published: February 2018

Multiple epidemiologic studies have evaluated the relationship between dietary cholesterol and lung cancer risk, but the association is controversial and inconclusive. A meta-analysis of case-control studies and cohort studies was conducted to evaluate the relationship between dietary cholesterol intake and lung cancer risk in this study. A relevant literature search up to October 2017 was performed in Web of Science, PubMed, China National Knowledge Infrastructure, Sinomed, and VIP Journal Integration Platform. Ten case-control studies and six cohort studies were included in the meta-analysis, and the risk estimates were pooled using either fixed or random effects models. The case-control studies with a total of 6894 lung cancer cases and 29,736 controls showed that dietary cholesterol intake was positively associated with lung cancer risk (Odds Ratio = 1.70, 95% Confidence Interval: 1.43–2.03). However, there was no evidence of an association between dietary cholesterol intake and risk of lung cancer among the 241,920 participants and 1769 lung cancer cases in the cohort studies (Relative Risk = 1.08, 95% Confidence Interval: 0.94–1.25). Due to inconsistent results from case-control and cohort studies, it is difficult to draw any conclusion regarding the effects of dietary cholesterol intake on lung cancer risk. Carefully designed and well-conducted cohort studies are needed to identify the association between dietary cholesterol and lung cancer risk.
A Plant-Based Dietary Intervention Improves Beta-Cell Function and Insulin Resistance in Overweight Adults: A 16-Week Randomized Clinical Trial
Authors: Kahleova Hana , Tura Andrea , Hill Martin , Holubkov Richard , Barnard Neal
Published: February 2018

The aim of this study was to test the effect of a plant-based dietary intervention on beta-cell function in overweight adults with no history of diabetes. Participants (n = 75) were randomized to follow a low-fat plant-based diet (n = 38) or to make no diet changes (n = 37) for 16 weeks. At baseline and 16 weeks, beta-cell function was quantified with a mathematical model. Using a standard meal test, insulin secretory rate was calculated by C-peptide deconvolution. The Homeostasis Model Assessment (HOMA-IR) index was used to assess insulin resistance while fasting. A marked increase in meal-stimulated insulin secretion was observed in the intervention group compared with controls (interaction between group and time, Gxt, p < 0.001). HOMA-IR index fell significantly (p < 0.001) in the intervention group (treatment effect −1.0 (95% CI, −1.2 to −0.8); Gxt, p = 0.004). Changes in HOMA-IR correlated positively with changes in body mass index (BMI) and visceral fat volume (r = 0.34; p = 0.009 and r = 0.42; p = 0.001, respectively). The latter remained significant after adjustment for changes in BMI (r = 0.41; p = 0.002). Changes in glucose-induced insulin secretion correlated negatively with BMI changes (r = −0.25; p = 0.04), but not with changes in visceral fat. Beta-cell function and insulin sensitivity were significantly improved through a low-fat plant-based diet in overweight adults.
Preparation of 2-Aminothiazole-Functionalized Poly(glycidyl methacrylate) Microspheres and Their Excellent Gold Ion Adsorption Properties
Authors: Xiong Chao , Wang Shixing , Zhang Libo , Li Ying , Zhou Yang , Peng Jinhui
Published: February 2018

A new adsorbent(A-PGMA) has been synthesized via functionalizing poly(glycidyl methacrylate) microsphere with 2-aminothiazole and used to adsorb gold ions from aqueous solutions. The adsorbent was characterized by X-ray photoelectron spectroscopy (XPS), Brunauer–Emmett–Teller (BET), Zeta potential, scanning electron microscope (SEM) and Fourier transform infrared spectroscopy (FT-IR). The influence factors such as the pH value of the solution, the initial gold ion concentration and the contact time were examined. Simultaneously, the adsorption process of the gold ion on A-PGMA fitted well with the Langmuir and pseudo-second-order models, respectively. The results showed that the maximum adsorption capacity was 440.54 mg/g and the equilibrium time of adsorption was about 3 h under pH 4. Moreover, the adsorbent has a high reusability after five cycles and good selectivity from coexisting ions, including Zn(II), Mg(II), Cu(II), Ge(IV) and B(III). The adsorption mechanisms of gold ions were ion exchange and chelation between the sulfur and nitrogen groups on the surface of A-PGMA and AuCl4−. Therefore, the adsorbent has a great potential for adsorption of gold ions from aqueous solutions.
Production and Characterization of a Clotrimazole Liposphere Gel for Candidiasis Treatment
Authors: Esposito Elisabetta , Sguizzato Maddalena , Bories Christian , Nastruzzi Claudio , Cortesi Rita
Published: February 2018

This study describes the design and characterization of a liposphere gel containing clotrimazole for the treatment of Candida albicans. Lipospheres were produced by the melt-dispersion technique, using a lipid phase constituted of stearic triglyceride in a mixture with caprylic/capric triglyceride or an alkyl lactate derivative. The latter component was added to improve the action of clotrimazole against candida. The liposphere morphology and dimensional distribution were evaluated by scanning electron microscopy. Clotrimazole release kinetics was investigated by an in vitro dialysis method. An anticandidal activity study was conducted on the lipospheres. To obtain formulations with suitable viscosity for vaginal application, the lipospheres were added to a xanthan gum gel. The rheological properties, spreadability, leakage, and adhesion of the liposphere gel were investigated. Clotrimazole encapsulation was always over 85% w/w. The anticandidal study demonstrated that the encapsulation of clotrimazole in lipospheres increased its activity against Candida albicans, especially in the presence of the alkyl lactate derivative in the liposphere matrix. A dialysis method demonstrated that clotrimazole was slowly released from the liposphere gel and that the alkyl lactate derivative further controlled clotrimazole release. Adhesion and leakage tests indicated a prolonged adhesion of the liposphere gel, suggesting its suitability for vaginal application.
Time-Resolving Study of Stress-Induced Transformations of Isotactic Polypropylene through Wide Angle X-ray Scattering Measurements
Authors: Auriemma Finizia , De Rosa Claudio , Di Girolamo Rocco , Malafronte Anna , Scoti Miriam , Mitchell Geoffrey , Esposito Simona
Published: February 2018

The development of a highly oriented fiber morphology by effect of tensile deformation of stereodefective isotactic polypropylene (iPP) samples, starting from the unoriented γ form, is studied by following the transformation in real time during stretching through wide angle X-ray scattering (WAXS) measurements. In the stretching process, after yielding, the initial γ form transforms into the mesomorphic form of iPP through mechanical melting and re-crystallization. The analysis of the scattering invariant measured in the WAXS region highlights that the size of the mesomorphic domains included in the well oriented fiber morphology obtained at high deformations increases through a process which involves the coalescence of the small fragments formed by effect of tensile stress during lamellar destruction with the domain of higher dimensions.
Effect of WS2 Inorganic Nanotubes on Isothermal Crystallization Behavior and Kinetics of Poly(3-Hydroxybutyrate-co-3-hydroxyvalerate)
Authors: Silverman Tyler , Naffakh Mohammed , Marco Carlos , Ellis Gary
Published: February 2018

Nanocomposites of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and tungsten disulfide inorganic nanotubes (INT-WS2) were prepared by blending in solution, and the effects of INT-WS2 on the isothermal crystallization behavior and kinetics of PHBV were investigated for the first time. The isothermal crystallization process was studied in detail using various techniques, with emphasis on the role of INT-WS2 concentration. Differential scanning calorimetry (DSC) and polarized optical microscopy (POM) showed that, in the nucleation-controlled regime, crystallization rates of PHBV in the nanocomposites are influenced by the INT-WS2 loading. Our results demonstrated that low loadings of INT-WS2 (0.1–1.0 wt %) increased the crystallization rates of PHBV, reducing the fold surface free energy by up to 24%. This is ascribed to the high nucleation efficiency of INT-WS2 on the crystallization of PHBV. These observations facilitate a deeper understanding of the structure-property relationships in PHBV biopolymer nanocomposites and are useful for their practical applications.
Poly(butylene 2,5-thiophenedicarboxylate): An Added Value to the Class of High Gas Barrier Biopolyesters
Authors: Guidotti Giulia , Gigli Matteo , Soccio Michelina , Lotti Nadia , Gazzano Massimo , Siracusa Valentina , Munari Andrea
Published: February 2018

Many efforts are currently devoted to the design and development of high performance bioplastics to replace traditional fossil-based polymers. In response, this contribution presents a new biobased aromatic polyester, i.e., poly(butylene 2,5-thiophenedicarboxylate) (PBTF). Here, PBTF is characterized from the molecular, thermo-mechanical and structural point of view. Gas permeability is evaluated at different temperatures, in the range below and above glass transition, providing a full insight into the performances of this material under different operating conditions, and demonstrating the superior gas barrier behavior of PBTF with respect to other polyesters, such as PEF and PET. The combination of calorimetric and diffractometric studies allows for a deep understanding of the structure of PBTF, revealing the presence of a not-induced 2D-ordered phase (meso-phase), responsible for its outstanding gas permeability behavior. The simple synthetic strategy adopted, the exceptional barrier properties, combined with the interesting mechanical characteristics of PBTF open up new scenarios in the world of green and sustainable packaging materials.
Truebounded, Overbounded, or Underbounded? Scientists’ Personal Publication Lists versus Lists Generated through Bibliographic Information Services
Authors: Dorsch Isabelle , Askeridis Johanna , Stock Wolfgang
Published: February 2018

A truebounded publication list of a scientific author consists of exactly all publications that meet two criteria: (1) they are formally published (e.g., journal article or proceeding paper); (2) they have scientific, scholarly, or academic content. A publication list is overbounded if it includes documents which do not meet the two criteria (such as novels); a publication list is underbounded if it is incomplete. Are authors’ personal publication lists, found on their personal sites on the Internet or in institutional repositories, truebounded, overbounded, or underbounded? And are the respective publication lists generated through bibliographic information services truebounded, overbounded, or underbounded? As case studies, publications of nine International Society of Scientometrics and Informetrics (ISSI) Committee members (published between 2007 and 2016) were collected to create preferably complete personal publication lists according to the two criteria. We connect the “relative visibility of an author” with the concepts of truebounded, overbounded, and underbounded publication lists. The authors’ relative visibility values were determined for the information services Web of Science (WoS), Scopus, and Google Scholar and compared to the relative visibility of the authors’ personal publication lists. All results of the bibliographic information services are underbounded. Relative visibility is highest in Google Scholar, followed by Scopus and WoS.
Who Benefits from Consociationalism? Religious Disparities in Lebanon’s Political System
Authors: Vaughan Kenneth
Published: February 2018

This study examines the extent to which confessional identities in Lebanon are responsible for shaping individual views toward their government. Specifically, I investigate disparities between religious groups in their perceptions of democracy and democratic principles as applied in Lebanon. Using nationally representative data from the Arab Barometer’s survey of Lebanon, I find that when compared to Maronite Catholics, Druze, and Sunni Muslims, Shia Muslims consistently give higher evaluations of the democratic condition of Lebanon. When compared to members of other religious groups, Shia Muslims are also more trusting of government institutions and perceive Lebanon to be freer. I find little evidence that the application of consociational theory equally and proportionally represents the political needs of the religious groups intended to be served. Rather, my findings reveal religious disparities in evaluations of democracy and political institutions in Lebanon, supporting critics of consociationalism who argue that consociationalism essentializes group-identity to political disputes.
Impossible Subjects: LGBTIQ Experiences in Australian Pentecostal-Charismatic Churches
Authors: Jennings Mark
Published: February 2018

This paper is the product of in-depth interviews with 20 Lesbian, Gay, Bisexual, Transgender, Intersex, and Queer (LGBTIQ) people who identify, or formerly identified, as members of Pentecostal-Charismatic Christian (PCC) churches. Interviewees typically found themselves confronted with a number of choices (not necessarily mutually exclusive): remain closeted, come out but commit to remaining celibate, undergo “SOCE” (Sexual Orientation Conversion Efforts) therapy, or leave. Most left their churches, often after agonising attempts to reconcile their faith and their sexuality. Several of the practices adopted by Australian PCC churches exclude LGBTIQ people from full participation in their own congregations, rendering them “impossible subjects.” Australian Pentecostalism’s surprisingly egalitarian history, wherein the spiritually authorised ministry of women was both recognised and celebrated, suggests another, more inclusive way forward in regard to this vexed issue.
The Influence of Sub-Block Position on Performing Integrated Sensor Orientation Using In Situ Camera Calibration and Lidar Control Points
Authors: Costa Felipe , Mitishita Edson , Martins Marlo
Published: February 2018

The accuracy of photogrammetric and Lidar dataset integration is dependent on the quality of a group of parameters that models accurately the conditions of the system at the moment of the survey. In this sense, this paper aims to study the effect of the sub-block position in the entire image block to estimate the interior orientation parameters (IOP) in flight conditions to be used in integrated sensor orientation (ISO). For this purpose, five sub-blocks were extracted in different regions of the entire block. Then, in situ camera calibrations were performed using sub-blocks and sets of Lidar control points (LCPs), computed by a three planes’ intersection extracted from the Lidar point cloud on building roofs. The ISO experiments were performed using IOPs from in situ calibrations, the entire image block, and the exterior orientation parameters (EOP) from the direct sensor orientation (DSO). Analysis of the results obtained from the ISO experiments performed show that the IOP from the sub-block positioned at the center of the entire image block can be recommended.
Explaining Leaf Nitrogen Distribution in a Semi-Arid Environment Predicted on Sentinel-2 Imagery Using a Field Spectroscopy Derived Model
Authors: Ramoelo Abel , Cho Moses
Published: February 2018

Leaf nitrogen concentration (leaf N, %) is an essential component for understanding biogeochemical cycling. Leaf N is a good indicator of grass or forage quality, which is important for understanding the movements and feeding patterns of herbivores. Leaf N can be used as input for rangeland carrying capacity and stocking rate models. The estimation of leaf N has been successful using hyperspectral and commercial high spatial resolution satellite data such as WorldView-2 and RapidEye. Empirical methods have been used successfully to estimate leaf N, on the basis that it correlates with leaf chlorophyll. As such, leaf N was estimated using red edge based indices. The new Sentinel-2 sensor has two red edge bands, is freely available, and could further improve the estimation of leaf N at a regional scale. The objective of this study is to develop red edge based Sentinel-2 models derived from an analytical spectral device (ASD) spectrometer to map and monitor leaf N using Sentinel-2 images. Field work for leaf N and ASD data were collected in 2014 (December) in and around Kruger National Park, South Africa. ASD data were resampled to the Sentinel-2 spectral configuration using the spectral response function. The Sentinel-2 data for various dates were acquired from the European Space Agency (ESA) portal. The Sentinel-2 atmospheric correction (Sen2Cor) process was implemented. Simple empirical regression was used to estimate leaf N. High leaf N prediction accuracy was achieved at the ASD level and the best model was inverted on Sentinel-2 images to explain leaf N distribution at a regional scale over time. The spatial distribution of leaf N is influenced by the underlying geological substrate, fire frequency and other environmental variables. This study is a demonstration of how ASD data can be used to calibrate Sentinel-2 for leaf N estimation and mapping.
Optical Fiber Sensors Based on Fiber Ring Laser Demodulation Technology
Authors: Xie Wen-Ge , Zhang Ya-Nan , Wang Peng-Zhao , Wang Jian-Zhang
Published: February 2018

A review for optical fiber sensors based on fiber ring laser (FRL) demodulation technology is presented. The review focuses on the principles, main structures, and the sensing performances of different kinds of optical fiber sensors based on FRLs. First of all, the theory background of the sensors has been discussed. Secondly, four different types of sensors are described and compared, which includes Mach–Zehnder interferometer (MZI) typed sensors, Fabry–Perot interferometer (FPI) typed sensors, Sagnac typed sensors, and fiber Bragg grating (FBG) typed sensors. Typical studies and main properties of each type of sensors are presented. Thirdly, a comparison of different types of sensors are made. Finally, the existing problems and future research directions are pointed out and analyzed.
A Dynamic Approach to Rebalancing Bike-Sharing Systems
Authors: Chiariotti Federico , Pielli Chiara , Zanella Andrea , Zorzi Michele
Published: February 2018

Bike-sharing services are flourishing in Smart Cities worldwide. They provide a low-cost and environment-friendly transportation alternative and help reduce traffic congestion. However, these new services are still under development, and several challenges need to be solved. A major problem is the management of rebalancing trucks in order to ensure that bikes and stalls in the docking stations are always available when needed, despite the fluctuations in the service demand. In this work, we propose a dynamic rebalancing strategy that exploits historical data to predict the network conditions and promptly act in case of necessity. We use Birth-Death Processes to model the stations’ occupancy and decide when to redistribute bikes, and graph theory to select the rebalancing path and the stations involved. We validate the proposed framework on the data provided by New York City’s bike-sharing system. The numerical simulations show that a dynamic strategy able to adapt to the fluctuating nature of the network outperforms rebalancing schemes based on a static schedule.
Nuclear Radiation Degradation Study on HD Camera Based on CMOS Image Sensor at Different Dose Rates
Authors: Wang Congzheng , Hu Song , Gao Chunming , Feng Chang
Published: February 2018

In this work, we irradiated a high-definition (HD) industrial camera based on a commercial-off-the-shelf (COTS) CMOS image sensor (CIS) with Cobalt-60 gamma-rays. All components of the camera under test were fabricated without radiation hardening, except for the lens. The irradiation experiments of the HD camera under biased conditions were carried out at 1.0, 10.0, 20.0, 50.0 and 100.0 Gy/h. During the experiment, we found that the tested camera showed a remarkable degradation after irradiation and differed in the dose rates. With the increase of dose rate, the same target images become brighter. Under the same dose rate, the radiation effect in bright area is lower than that in dark area. Under different dose rates, the higher the dose rate is, the worse the radiation effect will be in both bright and dark areas. And the standard deviations of bright and dark areas become greater. Furthermore, through the progressive degradation analysis of the captured image, experimental results demonstrate that the attenuation of signal to noise ratio (SNR) versus radiation time is not obvious at the same dose rate, and the degradation is more and more serious with increasing dose rate. Additionally, the decrease rate of SNR at 20.0, 50.0 and 100.0 Gy/h is far greater than that at 1.0 and 10.0 Gy/h. Even so, we confirm that the HD industrial camera is still working at 10.0 Gy/h during the 8 h of measurements, with a moderate decrease of the SNR (5 dB). The work is valuable and can provide suggestion for camera users in the radiation field.
Mutual-Information-Based Incremental Relaying Communications for Wireless Biomedical Implant Systems
Authors: Liao Yangzhe , Leeson Mark , Cai Qing , Ai Qingsong , Liu Quan
Published: February 2018

Network lifetime maximization of wireless biomedical implant systems is one of the major research challenges of wireless body area networks (WBANs). In this paper, a mutual information (MI)-based incremental relaying communication protocol is presented where several on-body relay nodes and one coordinator are attached to the clothes of a patient. Firstly, a comprehensive analysis of a system model is investigated in terms of channel path loss, energy consumption, and the outage probability from the network perspective. Secondly, only when the MI value becomes smaller than the predetermined threshold is data transmission allowed. The communication path selection can be either from the implanted sensor to the on-body relay then forwards to the coordinator or from the implanted sensor to the coordinator directly, depending on the communication distance. Moreover, mathematical models of quality of service (QoS) metrics are derived along with the related subjective functions. The results show that the MI-based incremental relaying technique achieves better performance in comparison to our previous proposed protocol techniques regarding several selected performance metrics. The outcome of this paper can be applied to intra-body continuous physiological signal monitoring, artificial biofeedback-oriented WBANs, and telemedicine system design.
Tuning the Stiffness Balance Using Characteristic Frequencies as a Criterion for a Superconducting Gravity Gradiometer
Authors: Liu Xikai , Ma Dong , Chen Liang , Liu Xiangdong
Published: February 2018

Tuning the stiffness balance is crucial to full-band common-mode rejection for a superconducting gravity gradiometer (SGG). A reliable method to do so has been proposed and experimentally tested. In the tuning scheme, the frequency response functions of the displacement of individual test mass upon common-mode accelerations were measured and thus determined a characteristic frequency for each test mass. A reduced difference in characteristic frequencies between the two test masses was utilized as the criterion for an effective tuning. Since the measurement of the characteristic frequencies does not depend on the scale factors of displacement detection, stiffness tuning can be done independently. We have tested this new method on a single-component SGG and obtained a reduction of two orders of magnitude in stiffness mismatch.
Fast Focal Point Correction in Prism-Coupled Total Internal Reflection Scanning Imager Using an Electronically Tunable Lens
Authors: Zhu Chenggang , Ge Bilin , Chen Ru , Zhu Xiangdong , Mi Lan , Ma Jiong , Wang Xu , Zheng Fengyun , Fei Yiyan
Published: February 2018

Total internal reflection (TIR) is useful for interrogating physical and chemical processes that occur at the interface between two transparent media. Yet prism-coupled TIR imaging microscopes suffer from limited sensing areas due to the fact that the interface (the object plane) is not perpendicular to the optical axis of the microscope. In this paper, we show that an electrically tunable lens can be used to rapidly and reproducibly correct the focal length of an oblique-incidence scanning microscope (OI-RD) in a prism-coupled TIR geometry. We demonstrate the performance of such a correction by acquiring an image of a protein microarray over a scan area of 4 cm2 with an effective resolution of less than 20 microns. The electronic focal length tuning eliminates the mechanical movement of the illumination lens in the scanning microscope and in turn the noise and background drift associated with the motion.