bluuebunny/crossref_metadata_2025 huggingface dataset:
A major locus confers triclabendazole resistance in Fasciola hepatica and shows dominant inheritance
Authors: Beesley Nicola J. , Cwiklinski Krystyna , Allen Katherine , Hoyle Rebecca C. , Spithill Terry W. , La Course E. James , Williams Diana J. L. , Paterson Steve , Hodgkinson Jane E.
Published: January 2023

Fasciola hepaticainfection is responsible for substantial economic losses in livestock worldwide and poses a threat to human health in endemic areas. The mainstay of control in livestock and the only drug licenced for use in humans is triclabendazole (TCBZ). TCBZ resistance has been reported on every continent and threatens effective control of fasciolosis in many parts of the world. To date, understanding the genetic mechanisms underlying TCBZ resistance has been limited to studies of candidate genes, based on assumptions of their role in drug action. Taking an alternative approach, we combined a genetic cross with whole-genome sequencing to localise a ~3.2Mbp locus within the 1.2GbpF.hepaticagenome that confers TCBZ resistance. We validated this locus independently using bulk segregant analysis ofF.hepaticapopulations and showed that it is the target of drug selection in the field. We genotyped individual parasites and tracked segregation and reassortment of SNPs to show that TCBZ resistance exhibits Mendelian inheritance and is conferred by a dominant allele. We defined gene content within this locus to pinpoint genes involved in membrane transport, (e.g. ATP-binding cassette family B, ABCB1), transmembrane signalling and signal transduction (e.g. GTP-Ras-adenylyl cyclase and EGF-like protein), DNA/RNA binding and transcriptional regulation (e.g. SANT/Myb-like DNA-binding domain protein) and drug storage and sequestration (e.g. fatty acid binding protein, FABP) as prime candidates for conferring TCBZ resistance. This study constitutes the first experimental cross and genome-wide approach for any heritable trait inF.hepaticaand is key to understanding the evolution of drug resistance inFasciolaspp. to inform deployment of efficacious anthelmintic treatments in the field.
Targeting RNA G-quadruplex with repurposed drugs blocks SARS-CoV-2 entry
Authors: Tong Qiyu , Liu Geng , Sang Xiongbo , Zhu Xinyue , Fu Xiaoli , Dou Chao , Jian Yue , Zhang Jiani , Zou Sailan , Zhang Guixiang , Du Xiao , Liu Dan , Qi Shiqian , Cheng Wei , Tian Yan , Fu Xianghui
Published: January 2023

The rapid emergence of SARS-CoV-2 variants of concern, the complexity of infection, and the functional redundancy of host factors, underscore an urgent need for broad-spectrum antivirals against the continuous COVID-19 pandemic, with drug repurposing as a viable therapeutic strategy. Here we report the potential of RNA G-quadruplex (RG4)-targeting therapeutic strategy for SARS-CoV-2 entry. Combining bioinformatics, biochemical and biophysical approaches, we characterize the existence of RG4s in several SARS-CoV-2 host factors.In silicoscreening followed by experimental validation identify Topotecan (TPT) and Berbamine (BBM), two clinical approved drugs, as RG4-stabilizing agents with repurposing potential for COVID-19. Both TPT and BBM can reduce the protein level of RG4-containing host factors, including ACE2, AXL, FURIN, and TMPRSS2. Intriguingly, TPT and BBM block SARS-CoV-2 pseudovirus entry into target cellsin vitroand murine tissuesin vivo. These findings emphasize the significance of RG4 in SARS-CoV-2 pathogenesis and provide a potential broad-spectrum antiviral strategy for COVID-19 prevention and treatment.
“Smart Beaches”: análisis del concepto de gestión inteligente aplicado a las playas
Authors: García Márquez Carlos , Caballero Acedo José David , Cantero Prados Francisco José , Guevara Plaza Antonio Jesús
Published: January 2023

El presente trabajo analiza las estrategias de gestión turística implantadas en las denominadas Playas Inteligentes existentes en España. Esta revisión toma como referencia los conceptos de Ciudad y Destino Inteligente, para proponer una metodología dividida en dos fases: la primera de ellas conceptual, considerando los criterios de gestión en las normas de gestión de playas más empleadas en el país; y en segundo lugar calibradora, extrayendo las mejores prácticas. Así, se presenta una serie de requisitos, con sus respectivas definiciones y experiencias nacionales, que constatan el importante papel de España en el contexto de la inteligencia turística internacional.
Wine tourism in Spain: The economic impact derived from visits to wineries and museums on wine routes
Authors: Martínez-Falcó Javier , Marco-Lajara Bartolomé , Zaragoza-Sáez Patrocinio , Sánchez-García Eduardo
Published: January 2023

Wine and tourism represent a perfect symbiosis, as they offer a different experience to tourists and also promote the economic, social, and environmental development of wine regions. In Spain, wine tourism is an increasingly important research field and several studies have been conducted on the role of wine routes in boosting the competitiveness of a territory, increasing wine production, improving the quality of life of citizens, and respecting the environment. However, to the best of our knowledge, the economic impact generated by these routes in Spain has not been addressed in the academic literature. To overcome this research gap, this paper aims to analyze the supply and demand of tourism activities by examining the evolution of the institutions involved in the Spanish wine routes, on the one hand, and the economic impact of these routes, on the other. The results show a sharp drop in the supply of institutions and the demand for tourist routes in 2020 as a result of COVID-19, with a decrease of 2.58% in the total number of institutions adhered to the wine routes, a decrease of 73.53% in the total number of visitors to the different Wine Routes of Spain and a decrease of 74.7% in the economic impact compared to the previous year. Likewise, the research shows the existence of differences between the Wine Routes of Spain in terms of the number of visitors and their economic impact, which could serve as a guide for managers to make investments through acquisitions and/or their own investments in wineries located on the routes with the greatest economic impact..
Turismo internacional y pandemia. Análisis comparativo de Cancún y Mallorca
Authors: Somoza Medina Xosé
Published: January 2023

La pandemia de COVID-19 ha generado una importante crisis en el turismo internacional. Las restricciones impuestas tras la declaración de la OMS han dado paso a una apertura selectiva de las fronteras, con la intención de recuperar la economía y los viajes turísticos. El objetivo de este trabajo es realizar un estudio comparativo entre Cancún (Quintana Roo, México) y Mallorca (Islas Baleares, España), a través del análisis de sus datos turísticos y de las restricciones dictaminadas por sus respectivos gobiernos. Este estudio de casos permite comprobar como la recuperación está impulsada por los intereses de la industria, que intenta volver a toda prisa a la vieja normalidad, desoyendo los consejos del mundo académico que alientan un cambio estructural basado en la sostenibilidad y la resiliencia. Las periferias del placer del modelo de Turner continúan marcando las principales corrientes del turismo internacional, a pesar de la pandemia.
The Relationship Between Competency Framework and Research Performance: An Empirical Study in The Public Research Institutes in Vietnam
Authors: Huy Tran Quang , Minh Hoang , Giang Tu Thao Huong
Published: January 2023

Competency framework has been studied widely for human resource development in organizations, but there are a few publications about researcher competency-based development in public research institutes. Therefore, the purpose of this paper is to investigate the relationship between competency framework and research performance in public research institutes to promote research career development in Vietnam. Data collected from 600 researchers in public research institutes used for analyses. Confirmatory factor analysis technique (CFA) and hierarchical multiple regression were applied to test the relationship between competency framework and research performance. The results provide supports for the view that competency framework positively affects research performance and task frequency positively moderates the relationship between competency framework and research performance in public research institutes. This paper explores the concept of competency framework for researchers in the public research institute context and clarifies its affect to the development of science, technology and innnovation in Vietnam.

 
Keywords: Competency framework, public research institute, technical competency, research performance, Vietnam.
Dynamics of Capability Upgrading in Indonesian Herbal Medicine Firms
Authors: Aminullah Erman
Published: January 2023

This article examined the dnamics of capability upgrading in Indonesian herbal medicine firms for empirical and future trends analysis. The dynamics of capability upgrading was analysed by using system dynamics modelling.  New knowledge was revealed from system  dynamics analysis of capability upgrading in Indonesian herbal medicine firms, the core ideas are: capability upgrading in Indonesian herbal medicine firms   can be realized by two routes: i. the linier moving up of  technological capability ladders from traditional herbal  to standardized herbal and phytopharmaceutical medicine, and, ii.  the non-linier dynamic of technological capability upgrading by directly producing standardized herbal by using R&D and then move-up to create phytopharmaceutical medicine.  The enabler factors of company’s success in capability upgrading were innovation collaboration and management coordination led by top management. The process of  capability upgrading can be accelareted by  incporporating: advanced knowledge base (such as biotechnology), the entrepreneurial activities of leading firms, and institutional/regulatory support from the government..

 
Keywords: capability upgrading, herbal medicine, system dynamics, future trends, enabler factors.
Digital Transformation in The Agriculture Sector: Exploring The Shifting Role of Extension Workers
Authors: Sugihono Chris , Juniarti Hafni Amalia , Nugroho Novendra Cahyo
Published: January 2023

Dunia akan terus berkembang secara digital. Meningkatnya penggunaan teknologi digital secara eksponensial telah mendorong disrupsi, termasuk di sektor pertanian. Kehadiran teknologi digital telah mengubah cara orang berkomunikasi, belajar, dan berinteraksi. Kondisi ini juga menjadi tantangan baru bagi penyuluh pertanian bagaimana menyikapi perubahan masyarakat. Tulisan ini bertujuan (1) untuk menganalisis wawasan tentang bagaimana teknologi digital mentransformasi sektor pertanian Indonesia dan (2) untuk mengeksplorasi pergeseran peran penyuluh pertanian di era digital. Metode pendekatan yang digunakan adalah kualitatif. Kami menggunakan data kualitatif (pengamatan online) yang dikumpulkan di World Wide Web dengan observasi yang tidak mengganggu dan data dari tinjauan pustaka. Hasil penelitian menunjukkan teknologi digital mengubah sektor pertanian dalam dua hal, sistem pangan, dan sistem pengetahuan dan inovasi pertanian. Tulisan ini mencoba menunjukkan bahwa digitalisasi telah mengubah peran penyuluh pertanian. Peran Penyuluh diperbaharui untuk menyesuaikan diri dengan ekosistem digital, seperti informan, konsultan, penasehat, fasilitator, mediator, dan promotor. Serta perluasan peran penyuluh di bidang baru yaitu penyuluh sebagai content creator dan influencer, gatekeeper, translator, sense makers, expert user, big data analyst, artificial intelligence dan digital twin data scientist, pengambil keputusan , pengembang perangkat lunak, dan pembuat gamify. Sementara itu, untuk menjawab dua tantangan besar tersebut,
A börtönoktatás hatékonyságának vizsgálata női fogvatartottak körében
Authors: Di Blasio Barbara , Ács-Bíró Adrienn
Published: January 2023

Tanulmányunkban bemutatjuk, hogy a nemzetközi kutatások milyen
empirikus adatokkal igazolják a börtönben zajló oktatás eredményességét,
hasznosulását. Ehhez kapcsolódik kutatásunk célja, a női fogvatartottak
nevelési és képzési szempontú profiljának felállítása, amely nemzetközi
szinten is elhanyagolt terület. Vizsgálatunkban a börtönoktatás rendszerébe
egyszerűen beépíthető és alkalmazható mérőeszközt használtunk. A Kognitív
Profil Teszttel három fő területen mértünk: kognitív képességek,
információfeldolgozás, iskolai készségek. Arra a kérdésre kerestük a
választ, hogy a jelenlegi reintegrációt támogató iskolai felkészítés
mennyiben járul hozzá szabadulást követően a nők társadalmi
visszailleszkedéséhez. Eredményeink alapján a vizsgálati csoport jelentős
eltérést mutat a viszonyítási csoportként szolgáló felnőtt populáció
jellemzőihez képest. A reintegrációt támogató életvezetési stratégia
kialakításához szükséges kognitív területek hiányosságai jelentősek.
Alátámasztást nyert, hogy az oktatásban a nők erőssége (figyelem,
holisztikus gondolkodás), illetve előnyös képességszintje nem kiaknázott.
Gyengeségeikre (iskolai készségek, absztrakció, szekvenciális gondolkodás)
nincs célzott segítség, így a fejlesztések hatása esetleges. Kutatásunk
megerősítette, hogy a többségi iskola mintáján szerveződő börtönoktatás
módszertana kevéssé hatékony az összetett problémahálóval küzdő női
elítéltek számára.
Survival predictors in patients with ectopic acth syndrome
Authors: Golounina O. O. , Belaya Zh. E. , Rozhinskaya L. Ya. , Pikunov M. Yu. , Markovich A. A. , Dzeranova L. K. , Marova E. I. , Kuznetsov N. S. , Fadeev V. V. , Melnichenko G. A. , Dedov I. I.
Published: January 2023

AIM: To determine significant factors affecting the survival of patients with ectopic ACTH syndrome (EAS).MATERIALS AND METHODS: A multi-center, observational study with a retrospective analysis of patients with EAS. The end point of the study was the fatal outcome of patients from various causes. In order to identify predictors of survival or mortality, univariate and multifactorial Cox regression analyses were carried out. ROC-analysis was used to determine the prognostic threshold values of individual predictors. The survival analysis was carried out using the Kaplan-Mayer method. Statistical data processing was carried out by using IBM SPSS Statistics 23.RESULTS: The age of patients at the time of diagnosis ranged from 12 to 76 years (Me 40 years [28;54]). The age of the studied population was 55 years [38; 64] for women and 42 years [32; 54] for men. The median period of observation was 50 months [13;91], with a maximum follow-up of 382 months. 92 patients (60,9%) had bronchopulmonary NET, 17 (11,3%) — thymic carcinoid, 8 — pancreatic NET, 5 –pheochromocytoma, 1– cecum NET, 1– appendix carcinoid tumor, 1 — medullary thyroid cancer and 26 (17,2%) patients had an occult NET. The primary tumor was removed in 101 patients (66,9%). Bilateral adrenalectomy was performed in 42 (27,8%) cases. Metastases were revealed in 23,2% (n=35) of patients. Relapse of the disease was observed in 24,4%, long-term remission was preserved in 64 patients (74,4%). Death occurred in 42 patients (28%). The average age of survivors was 47,0±15,2 versus 53,5±15,6 years for the deceased (p=0,022). The average survival time from diagnosis for the deceased was 32 months, Me 16,5 months [7;54]. Multivariate analysis revealed that the following factors have a direct impact on survival: age of diagnosis ≥51 years (OR 4,493; 95% CI 2,056–9,818, p<0,001), bronchopulmonary neuroendocrine tumor (NET) (OR 0,281; 95% CI 0,119–0,665, p=0,004), the presence of distant metastases (OR 2,489; 95% CI 1,141–5,427, p=0,022), late-night salivary cortisol (LNSC) ≥122,2 nmol/L (OR 2,493; 95% CI 1,014–6,128, p=0,047).CONCLUSION: The prognosis of patients with EAS is influenced by the age of diagnosis, NET localization, distant metastases and level of LNSC. The most common cause of ectopic ACTH syndrome was bronchopulmonary NET which was associated with the best survival rate.
Case of clinically “aggressive” course of primary hyperparathyroidism, algorithm of differential diagnosis
Authors: Matyushkina A. S. , Gorbacheva A. M. , Tkachuk A. V. , Eremkina A. K. , Mokrysheva N. G.
Published: January 2023

Primary hyperparathyroidism (PHPT) is a significant endocrine disease caused by increased production of parathyroid hormone (PTH) by altered parathyroid glands and violation of the mechanisms of regulation of serum calcium concentrations. These changes can lead to nephrolithiasis, osteoporosis, erosive and ulcerative lesions of the gastrointestinal tract, a number of less specific symptoms (nausea, vomiting, weakness, fatigue, etc.). Etiologically, in more than 85% of cases, PHPT is a consequence of sporadic solitary adenoma or hyperplasia parathyroid glands, however, in 1–3% of cases, the cause is carcinoma of parathyroid glands , including as part of various genetic syndromes. The importance of timely examination for PHPT of patients with characteristic clinical manifestations of this disease and — with an aggressive course — alertness towards carcinomas of parathyroid glands was noted. At the same time, the severity of the clinical picture and even the presence of suspicious signs characteristic of hereditary forms of carcinomas of parathyroid glands are not always a consequence of the malignant process. We present a description of a young patient with a severe course of PHPT, multiple fractures and a voluminous tumor of the upper jaw, developed as a result of a typical adenoma of parathyroid glands. Additionally, the algorithm of pre- and postoperative differential diagnosis for such patients is highlighted.
Morphological predictors of the efficacy of mitotane therapy in adrenocortical cancer
Authors: Tkachuk A. V. , Beltsevich D. G. , Porubayeva E. E. , Urusova L. S.
Published: January 2023

BACKGROUND: Adrenocortical cancer (ACC) is an orphan malignant tumor of the adrenal cortex with a predominantly poor prognosis and an aggressive clinical course. Nowadays, mitotane is a non-alternative drug in the treatment of ACC. The search for prognostic parameters that determine the sensitivity of ACC to ongoing treatment is currently an urgent task. Expression levels of the large subunit of ribonucleotide reductase M1 (RRM1), cytochrome P450 2W1 (CYP2W1), and sterol- O-acyltransferase-1 (SOAT1) are considered as potential predictors of response to mitotane therapy.AIM: To assess the immunohistochemical expression of RRM1, CYP2W1 and SOAT1 in ACC as markers of clinical outcomes and response to the therapy with mitotane.MATERIALS AND METHODS: The study included 62 patients older than 17 years of age with a diagnosis of ACC confirmed histologically and immunohistochemically. Mitotane therapy was initiated in 29 patients in the postoperative period, 33 patients were under dynamic observation without concomitant drug treatment. Antibodies to RRM1, CYP2W1, SOAT1 were used diluted in accordance with recommendations of firms-manufacturers for immunohistochemical detection. RESULTS: In the group of patients with low and moderate RRM1, CYP2W1 and SOAT1 immunoreactivity in the tumor and no antitumor therapy, a better DFS was noted (p=0.037, p=0.020 and p=0.001, respectively) compared to the group of patients receiving mitotane therapy at this level of marker expression. With high immunoreactivity of the markers, no statistically significant differences in DFS were found.CONCLUSION: Consistent with the findings in our study, low expression of RRM1, CYP2W1 and SOAT1 was associated with worse DFS with antitumor therapy. The results of the work indicate the need to assess the levels of immunoreactivity of these markers in patients with ACC before starting treatment with mitotane in order to predict the efficiency of therapy.
The role of estriol in the treatment of atrophy of the mucous membrane of the lower genitourinary tract in postmenopausal women
Authors: Andreeva E. N. , Sheremetyeva E. V.
Published: January 2023

Studies of recent decades show a steady increase in the average life expectancy of a person, and women in particular. The World Health Organization predicts a four-fold increase in the number of women over 70 by 2030, and many of them over the age of 45 may face menopausal problems. Menopause is a physiological state in a woman’s life, during which, against the background of age-related changes, there is a gradual decrease and shutdown of ovarian function and the cessation of estrogen production. Genitourinary syndrome occurs in every third woman in this period. Estriol is the main estrogen that specifically addresses problems associated with estrogen deficiency: dyspareunia, dryness and itching in the vagina and lower genitourinary tract, urinary incontinence, moderate urinary incontinence, and recurrent vulvovaginitis and cystitis. Vulvovaginal dystrophy in women of the older age group is a multidisciplinary problem at the intersection of gynecology, urology and dermatology, which can and should be solved to prevent more severe gynecological and urological pathologies.
Ética de la palabra
Authors: Espinel-Bernal Oscar
Published: January 2023

¿Qué es leer? ¿Qué es escribir? ¿Qué ocurre cuando se lee o cuando se escribe? ¿Qué tipo de relación se entreteje entre el texto y quien lo lee o escribe? ¿Qué tipo de efectos se derivan de allí? El acento de este tipo de preguntas pretende poner el foco de inquietud en el sujeto que lee y escribe. Con este propósito se emplean las nociones foucaultianas de ética, experiencia y cuidado de sí (epimeleia heaotou) para interrogar desde allí tanto el leer como el escribir. Pensar la lectura y la escritura desde la perspectiva metodológica de la producción de sí, deriva en una ética de la palabra y en el ejercicio de la escritura de sí, las cuales permiten, a su vez, aportar ángulos de interpelación, tanto a las prácticas de enseñanza, como a la formación y la investigación. 
Palabras clave: cuidado de sí, leer, escribir, ética de la palabra, experiencia
 
Ética da palavra. Leitura, escrita e produção de si.
Resumo: O que é ler? O que é escrever? O que ocorre quando se lê ou quando se escreve? Que tipo de relação se entretece entre o texto e quem o lê ou o escreve? Que tipos de efeitos são daí derivados? O tom dessas perguntas pretende ressaltar a inquietude no sujeito, o sujeito que lê e o sujeito que escreve. Com tal propósito, empregam-se noções foucaultianas de ética, experiência e cuidado de si (epiméleia heautoû) para interrogar, a partir daí, leitura e escritura, considerando a perspectiva metodológica da produção de si derivada de uma ética da palavra e de um exercício da escritura de si aos quais, por sua vez, permitem suscitar ângulos de interpelação tanto das práticas de ensino quanto da formação e da pesquisa.
Palavras-chave: cuidado de si; ler; escrever; ética da palavra; experiência
 
Ethics of the word. Reading, writing and production of the self
Abstract: What is reading? What is writing? What happens when reading or writing? What kind of relationship is weave between the text and the one who reads or writes it? What kind of effects derive from it? The accent of this type of questions intends to put the focus of concern on the subject, who reads and writes. To this end, the foucauldian notions of ethics, experience and care of the self (epimeleia heaotou) are used to interrogate reading and writing. Thinking about reading and writing from the methodological perspective of the production of the self, derives in an ethics of the word and in the exercise of the writing of the self, that allow us to contribute angles of interpellation to teaching practices, as well as to the formation and research.
Key words: The care of the Self, reading, writing, ethics of theWord, Experience.
 
Data de registro: 22/07/2022
Data de aceite: 13/12/2022
Realidades adaptadas
Authors: Juliano Ulisses
Published: January 2023

A inteligência artificial (IA) possui um poder único, de ablaquear o potencial humano de melhoria de resultados que as ferramentas tradicionais não são capazes de fazer. A pandemia serviu para evidenciar que a implementação de tecnologias disruptivas nas relações de trabalho é um caminho irreversível, sobre o qual se faz necessário uma reflexão madura e complexa sobre a relação do homem e essa tecnologia que está transformando cada vez mais as relações de trabalho, incentivando as capacidades humanas e proporcionando a construção de novas realidades. Atualmente a inteligência artificial promove uma diversidade de tecnologias convencionais que estão tendo um impacto substancial na vida cotidiana, neste contexto, é preciso voltar a atenção a observância dos direitos humanos nas relações de trabalho, que estão sendo impactadas pela IA. Com uma rápida visão histórica, é possível diagnosticarmos que a humanidade é uma constante dialética semiótica, numa busca esperançosa de um futuro melhor. Nesse cenário, novas formas de trabalho foram criadas enquanto que outras foram extintas, reformuladas ou adaptadas, em especial durante o período da pandemia.
Moderação de Conteúdo Online e as Batalhas entre o bem e o mal
Authors: Meneguetti Pereira Luciano
Published: January 2023

O presente artigo tem como objetivo analisar um dos temas mais problemáticos da sociedade digital contemporânea que é a moderação dos conteúdos produzidos na Internet, notadamente nas mídias sociais. A pesquisa justifica-se em razão das dificuldades que vêm sendo enfrentadas tanto em âmbito nacional como internacional no enfrentamento das complexas questões que a temática tem levantado. De um lado, práticas nefastas como a violência extremada, o discurso de ódio, o racismo, a intolerância (em suas mais diversas facetas), o engano viral online, teorias da conspiração e o cancelamento de pessoas promovido pelos “tribunais” da Internet têm promovido incontáveis violações de vários direitos no ambiente digital; de outro, a necessidade de uma efetiva proteção dos direitos violados por aquelas desprezíveis práticas e a tutela dos interesses das empresas proprietárias das plataformas digitais têm se mostrado cada vez mais importantes. Pela presente pesquisa conclui-se pela necessidade da moderação de conteúdo pela via estatal que observe os standards e parâmetros internacionais de proteção dos direitos humanos. Na pesquisa foi empregado o método dedutivo, utilizando-se como metodologia a pesquisa básica, qualitativa, exploratória e bibliográfica, lançando-se mão de doutrina autorizada de índole nacional e internacional.
Desanonimizando os doadores de esperma no Canadá
Authors: Cameron Angela , Gruben Vanessa , Kelly Fiona
Published: January 2023

Este artigo discute se o anonimato dos doadores de esperma deve permanecer no Canadá e quais efeitos existem pela abolição do anonimato, particularmente para grupos marginalizados como mães homossexuais. A primeira parte do artigo descreve o contexto legislativo e histórico em torno do debate sobre anonimato de doadores no Canadá. A segunda parte aborda os interesses dos diversos atores sociais e legais, incluindo os filhos concebidos pelos doadores, os pais socioafetivos e biológicos desses filhos e os doadores de esperma. Ao final discute a reforma dupla da lei. Primeiramente, propõe-se que o Canadá abole prospectivamente o anonimato dos doadores, em um esforço para as necessidades de saúde e psicológicas das crianças concebidas por doadores. Em segundo lugar, recomenda-se que as leis de parentalidade sejam simultaneamente alteradas para que sejam removidas as vulnerabilidades legais que as famílias lideradas por mulheres atualmente experienciam e que seriam exacerbadas pela desanonimização de doadores.
uso de dados pessoais pelo Twitter
Authors: Damasceno Gabriel Pedro Moreira , Guedes Rodrigues Thalissa , de Azevedo Rabelo Gustavo
Published: January 2023

Este trabalho tem como objetivo compreender a formação de bolhas sociais, o colonialismo de dados e o capitalismo de vigilância no que tange à atuação das big techs, no contexto da rede social Twitter, através da análise de seus termos de serviço, bem como as consequências jurídicas e sociais das bolhas sociais. Para isso, foram estudadas as políticas de privacidade, comportamento abusivo e mídia sensível do Twitter, além de pesquisa bibliográfica e documental, pelo exame de textos de autores que trataram dos temas relacionados ao trabalho. Ao fim do estudo, constatou-se que a personalização do conteúdo apresentado aos usuários da rede, através do tratamento dado aos seus dados pessoais, ocasiona a formação das bolhas sociais.
I Seminário Internacional de Direito Internacional Crítico
Authors: Cardoso Squeff Tatiana , Moreira Damasceno Gabriel Pedro
Published: January 2023

Trata-se da publicação dos resumos selecionados via double blind review, os quais foram selecionados para apresentação no evento intitulado ‘I Seminário Internacional de Direito Internacional Crítico’, realizado pelo Grupo de Estudos e Pesquisa Direito Internacional Crítico – DiCri/CNPq, vinculado à Universidade Federal de Uberlândia, entre os dias 13 e 15 de dezembro de 2021, na modalidade virtual, com o apoio da Revista.
New Jersey Fan Club: Artists and Writers Celebrate the Garden State
Authors: Sisler Lisa
Published: January 2023

Lisa Sisler reviewing New Jersey Fan Club: Artists and Writers Celebrate the Garden State, edited by Kerri Sullivan.
El sentido de comunidad y su medición
Authors: Ayala-Rodríguez Nelly , Camargo-Escobar Itala Marina , Cañas-Guzmán Julián Camilo , Ortiz-López Beatriz
Published: January 2023

El “Sentido de Comunidad” (SC) apareció en el mundo académico en 1974, expresado por Sarason. Flores (20l4) plantea que el sentimiento de comunidad es el producto del encuentro de diversas variables, y que tiene la función de ser catalizador para favorecer la participación comunitaria y el cambio social. El tema ha despertado interés en el ámbito de la Psicología Comunitaria (Bottom et al., 2013); son numerosas las investigaciones que determinan la relación del sentido de comunidad con procesos como el apoyo social o la competencia social y escolar (Arce et al., 2011; Castro, 2014; Chipuer & Pretty, 1999; Schweitzer et al., 2002), o con el bienestar y la calidad de vida (Hombrados-Mendieta & López-Espigares, 2014; Marco et al., 2015).
On Einstein-type almost Kenmotsu manifolds
Authors: Kumara Huchchappa Aruna , Praveena Mundalamane Manjappa , Naik Devaraja Mallesha
Published: January 2023

First, we consider a non-trivial Einstein-type equation on a Kenmotsu manifold M and show that either M is Einstein or the potential function is pointwise collinear with ξ on an open set

𝒰

{\mathcal{U}}

of M. Finally, we study an Einstein-type equation on an almost Kenmotsu

(
κ
,
μ
)

′

{(\kappa,\mu)^{\prime}}

-manifold.
The Macroeconomic Impact of Social Unrest
Authors: Hadzi-Vaskov Metodij , Pienknagura Samuel , Ricci Luca Antonio
Published: January 2023

This paper explores the macroeconomic impact of social unrest, using a novel index based on news reports. It shows that unrest has an adverse effect on economic activity, with GDP remaining on average 0.2 percent below the pre-unrest baseline six quarters after a one-standard deviation increase in the unrest index. Moreover, results are robust to instrumenting via regional unrest to address potential endogeneity concerns. Unrest “events”, captured by a large change in the unrest index, result in a more pronounced decline in GDP—a 1 percent reduction six quarters after the event—but impacts differ by type of event. The adverse impact of unrest on activity is mainly associated with sharp contractions in manufacturing and services, and consumption. However, it can be mitigated by strong institutions and by a country’s policy space (such as fiscal space and exchange rate flexibility).
Ab initio study of fundamental properties of XInO3 (X = K, Rb, Cs) perovskites
Authors: Bayhan Ülkü
Published: January 2023

The structural, elastic, anisotropic, and lattice dynamical properties of cubic perovskite compounds XInO3 (X = K, Rb, and Cs) are investigated using first-principles calculations. Electronic band structures and state densities revealed that the electronic nature of the studied materials exhibited half-metallicity properties. The existence of O p–d states close to the Fermi level contributes to the half-metallic properties. Moreover, polycrystalline properties, such as bulk, Young, and shear moduli and Pugh and Poisson ratios, have been determined. As a result of these characteristics, the compounds under consideration exhibited ductility behavior. As far as is known, since this is the first study of XInO3 (X = K, Rb, and Cs) compounds, this work sheds light on future works.
Macroscopic analysis of chemical looping combustion with ilmenite versus conventional oxides as oxygen carriers
Authors: Pérez-Méndez Mario Alberto , Fraga-Cruz Guadalupe Selene , Jiménez-García Gladys , Huirache-Acuña Rafael , Nápoles-Rivera Fabricio , Maya-Yescas Rafael
Published: January 2023

Over 40% of global energy-related CO2emissions are due to the combustion of fossil fuels for electric energy generation. Albeit CO2capture and storage have been identified as promissory actions to mitigate its emissions, the problem separating N2and CO2remains. A very effective solution for the former problem is to obtain the combustion CO2as a pure molecule, which is possible using the Chemical Looping Combustion (CLC) technology, which uses a solid oxygen carrier to transport the oxygen from an oxidating media (regeneration reactor) to a reducing media (combustion reactor). One of the key issues to apply CLC is to find or develop some material, suitable from the kinetic and thermodynamic points of view, for the reduction-oxidation cycles taking place inside combustion and regenerator reactors. The evaluation of “oxygen carrier” candidates for CLC is based on reactivity (rates and conversions), resistance to carbon accumulation, and “regenerability”, which means the ability of the material for cyclic reduction and oxidation. Another challenging issue to use CLC processes is the loss of oxygen carrier; this problem involves the use of supported metals on materials, such as zirconia, Al2O3, etc. Preparation of this kind of supported carriers requires time, money, and equipment. Meanwhile, the natural mineral ore named ilmenite, which consists of a mixture of iron and titanium oxides, and do not need to be supported, has been seen as promising to increase CLC efficiency as oxygen carrier. In this work, the performance of ilmenite is compared with some other oxygen carriers used in CLC.
Advances in electrochromic device technology through the exploitation of nanophotonic and nanoplasmonic effects
Authors: Hopmann Eric , Zhang Wu , Li Haizeng , Elezzabi Abdulhakem Y.
Published: January 2023

Research regarding electrochromic (EC) materials, such materials that change their color upon application of an electrochemical stimulus, has been conducted for centuries. However, most recently, increasing efforts have been put into developing novel solutions to utilize these on-off switching materials in advanced nanoplasmonic and nanophotonic devices. Due to the significant change in dielectric properties of oxides such as WO3, NiO, Mn2O3and conducting polymers like PEDOT:PSS and PANI, EC materials have transcended beyond simple smart window applications and are now found in plasmonic devices for full-color displays and enhanced modulation transmission and photonic devices with ultra-high on-off ratios and sensing abilities. Advancements in nanophotonic ECDs have further decreased EC switching speed by several orders of magnitude, allowing integration in real-time measurement and lab-on-chip applications. The EC nature of such nanoscale devices promises low energy consumption with low operating voltages paired with bistability and long lifetimes. We summarize these novel approaches to EC device design, lay out the current short comings and draw a path forward for future utilization.
Changes in water-vapor-adsorption isotherms of pulp fibers and sheets during paper recycling, including drying of wet webs, and disintegration and sonication of dried sheets in water
Authors: Kimura Minoru , Takeuchi Miyuki , Isogai Akira
Published: January 2023

A never-dried (ND) fines-free softwood bleached kraft pulp was converted to air-dried and thermally dried handsheets, which were then disintegrated or sonicated in water under various conditions. These disintegrated or sonicated pulps were converted to handsheets and used to obtain fundamental data on paper recycling. The water-vapor-adsorption isotherms of the pulp and sheet samples after super-critical-point drying showed clear differences between the water volumes adsorbed by the ND pulp, once-dried pulp, and dried sheets at the same relative humidities above 50%. These differences are caused by hornification of the pulp and sheet samples during drying and recycling. Air and thermal drying of wet webs decreased the adsorbed-water-vapor volume by 7%–9% and 14%–18%, respectively, relative to that adsorbed by the original ND pulp. We hypothesize that the decrease in water-vapor-adsorption volume from that of the original ND pulp at relative humidities >50% reflects the degree of irreversible formation of hydroxyl groups in the originally hydrophilic hemicelluloses and crystalline cellulose microfibril surfaces in the pulp and sheet samples during drying and paper recycling. The water-vapor-adsorption isotherms of pulp and sheet samples can be used to quantify the degree of hornification or the amount of irreversible hydrogen bonds formed during paper recycling.
Developing Affective Brands: Paratextualization in the Entertainment Industry
Authors: de Souza-Leão André Luiz Maranhão , Moura Bruno Melo , Lopes Mariana Almeida de Souza , Batista Marília Abigail Meneses , Melo Maria Eduarda da Mota , Santos Juliana Francisca Dutra dos
Published: January 2023

Fans’ relationship with media product franchises is strongly based on the symbolic value and sense of belonging that nurtures their consumer practices, a fact that indicates the love relationship with these brands. Entertainment brands increasingly resort to paratexts in order to expand their relationship with fans. Thus, the aim of the current research is to investigate how the paratextualization of franchise productions by the entertainment industry is used to trigger love towards their brands. In order to do so, it applied the Foucauldian Discourse Analysis to news reports and information published on websites of three of the most successful brands in the entertainment industry, namely: Star Wars, Wizarding World and Game of Thrones. Based on the results, these brands promote both the value and the continuity of the aforementioned sagas as means to develop an affective brand for their fans.
Representing the Stirling polynomials σ

n
(x) in dependence of n and an application to polynomial zero identities
Authors: Kovačec Alexander , de Tovar Sá Pedro Barata
Published: January 2023

Denote by

σ

n

{\sigma }_{n}

the n-th Stirling polynomial in the sense of the well-known book Concrete Mathematics by Graham, Knuth and Patashnik. We show that there exist developments

x

σ

n

(

x

)

=

∑

j
=
0

n

(

2

j

j
!

)

−
1

q

n
−
j

(

j

)

x

j

x{\sigma }_{n}\left(x)={\sum }_{j=0}^{n}{\left({2}^{j}j\!)}^{-1}{q}_{n-j}\left(j){x}^{j}

with polynomials

q

j

{q}_{j}

of degree

j
.

j.

We deduce from this the polynomial identities

∑

a
+
b
+
c
+
d
=
n

(

−
1

)

d

(

x
−
2
a
−
2
b

)

3
n
−
s
−
a
−
c

a
!
b
!
c
!
d
!

(

3
n
−
s
−
a
−
c

)

!

=
0
,

for

s
∈

Z

≥
1

,

\sum _{a+b+c+d=n}{\left(-1)}^{d}\frac{{\left(x-2a-2b)}^{3n-s-a-c}}{a\!b\!c\!d\!\left(3n-s-a-c)\!}=0,\hspace{1.0em}\hspace{0.1em}\text{for}\hspace{0.1em}\hspace{0.33em}s\in {{\mathbb{Z}}}_{\ge 1},

found in an attempt to find a simpler formula for the density function in a five-dimensional random flight problem. We point out a probable connection to Riordan arrays.
Challenges for Democratic State Budget Organization
Authors:   Universität Potsdam, Germany, Gutbrod Max
Published: January 2023

This thought piece is to, at a high level, address modern challenges to the manner budgets are organized in democratic states. To my mind, those challenges are manyfold and interlinked. Therefore, addressing them is dependent on an understanding of all of them. Clearly, each of the mentioned challenges in itself is intricate and deserves detailed attention. In order for the mentioned interlinks and the need for a succinct reduction of complex issues to succinct metrics become plausible I have chosen to here address the mentioned challenges from a high level and risking to not give justice to detail relevant to every of them. I find this appropriate in particular because of the tendency of intricate issues to be detailed and thereby even more difficult to understand. The discussion below shall start with taking positions of two key moments in history which, I think, are characteristic for the formation of budget rules. This historical review is followed by a discussion on how to ensure the most fundamental of relevant metrics, namely the money value that is the most obvious fundament for a population to usefully budget issues given that a majority of which will not consist of specialists that can quickly detect what is relevant about issues, and discussions around the Euro will be reviewed. Further, the consequences of state commitments to combat n against climate change having added a new type of obligations to be dealt with by state will be discussed. Finally, the consequences of states having taken substantial commitments to support investments, be it in renewable energy, be it in innovation at large, and the need having emerged to address flexible of targets will be discussed, and a summary drawn.
Information Support for the Analysis and Control of the Procurement of Goods, Works and Services of a Medical Organization
Authors:   Voronezh State University, Russian Federation, Korobeinikova Larisa , Krivosheyev Artem ,   Voronezh State University, Russian Federation
Published: January 2023

In the public sector, the optimization of procurement is the most important lever to increase efficiency. The purchase of goods and services make up the bulk of government spending, that is, the optimization of procurement can signifi cantly reduce budget expenditures. The effect of optimizing purchases is not limited to saving money. This tool is able to provide public institutions with a number of intangible advantages, one of which is transparency. Having accurate information about where and how much money is spent, as well as using simple standardized procedures for managing budget expenditures, managers can make more rational decisions. With balanced regulation of purchased goods through government orders, it can have a positive impact on pricing for certain types of products, giving it a certain flexibility. These circumstances determine the relevance of the study of the role of public procurement in the development of economic regulation of the economic system, the problems of forming theoretical, methodological and practical foundations of relevant qualitative changes in the field of public contracts
Фактическое Право на Доход в Налоговом Праве России: Основные Этапы Развития
Authors:   Moscow State Law University, Russian Federation, Matchekhin Victor
Published: January 2023

The concept of the beneficial ownership on income has been contained in Russian international tax treaties for more than 30 years. During this time, the tax authorities of Russia have formed practical approaches to the implementation of this concept, issuing instructions, recommendations and clarifications of the provisions of international tax treaties. The concept has experienced the first serious test in relation to the taxation of interest income paid on commercial Eurobonds of Russian issuers. But the active practice of applying this concept began in 2015, when the Tax Code of the Russian Federation included special provisions on the actual right to income and on the procedure for applying this concept. Judicial practice in Russia has shown numerous significant disagreements between the positions of tax authorities, taxpayers and tax agents. The legislative consolidation of the concept of the actual right to income and numerous legal disputes regarding the application of this concept in specific circumstances stimulated to its serious doctrinal understanding in Russia.
Kazakhstan’s Investment Legislation: Past, Present and Future
Authors:   Caspian University, Republic of Kazakhstan, Moroz Svetlana
Published: January 2023

This article is devoted to the study of the formation and development of investment legislation in the Republic of Kazakhstan. The author identifies five stages of the formation of Kazakhstan’s investment legislation from 1990 to the present. The author describes each stage of the development of investment legislation, analyzes all the enacted legislative acts and reforms that have been implemented to attract investors to the country’s economy. It is noted that the Republic of Kazakhstan since its independence has taken serious steps to create a favorable investment climate, and certain results in this direction have been achieved, but there are also problems. It is emphasized that cardinal changes in the country’s investment policy, constant reforms in the public administration system, the creation of various state bodies to regulate investors’ activities have a negative impact on Kazakhstan’s investment attractiveness. In this regard, the author concludes that it is necessary to change the investment policy in the field of granting tax preferences, improve the investment and tax legislation of Kazakhstan to ensure proper protection of investors’ rights.
Astana International Financial Center: Features of the Tax Regime and Legal Regulation of Cryptocurrency Turnover
Authors:   Research Institute of Financial and Tax Law, Republic of Kazakhstan, Proskurina Kristina
Published: January 2023

In its desire to encourage some individuals the State should not infringe the rights and legitimate interests of others. The investment policy of the State should not be discriminatory and should always, first of all, take into account the national (public) interests. However, the State is not always consistent, reasonable and fair in its investment policy in relation to the entire society. The state through public authorities and public officials is the spokesman of the public interests. In this case, the State must take these public interests into account when carrying out activities, in particular, when establishing preferential tax regimes, when attracting foreign investment by establishing a special investment tax residence for foreigners, when limiting the turnover of certain objects of legal relationship. In addition, the private interests of a certain circle of persons should not replace the public interests. The policy pursued by any State (tax, legal, social, economic) should be aimed at improving the standard of living of the entire society within a State. But not at the expense of the established constitutional and sectoral principles and values, as well as the rules of the international cooperation established in international agreements. The article discusses the problems of establishing a special preferential tax regimes on a territorial basis within a unitary State and the problems of legal regulation of cryptocurrency turnover in the territory of the Republic of Kazakhstan.