bluuebunny/crossref_metadata_2025 huggingface dataset:
Application of Nondestructive Testing Technologies in Preserving Historic Trees and Ancient Timber Structures in China
Authors: Xu Pengfei , Guan Cheng , Zhang Houjiang , Li Guanghui , Zhao Dong , Ross Robert J. , Shen Yinlan
Published: March 2021

In China, preserving historic trees and ancient timber structures has attracted more attention from researchers and institutions. Nondestructive testing (NDT) technology has gained momentum in the application and research in recent years. This paper presents some examples of the application of NDT techniques in the protection of historic trees and ancient timber structures in China. A total of nine NDT techniques were applied, including five techniques of visual inspection, sounding, Resistograph, stress wave transmission velocity, stress wave tomography for both historic trees and ancient timber structures, two techniques of the pulling-test and ground-penetrating radar (GPR) for historic trees alone, and two techniques of acoustic emission (AE) and digital imaging for ancient timber structures. Based on field testing, there is a very good detecting effect for visual inspection and Resistograph, but sounding works unsatisfactorily. The stress wave transmission velocity is found to be excellent in screening for the internal defects of historic tree trunks, but performs badly in screening for the internal defects within the wood members of ancient timber structures. AE is less successful but digital imaging performs well in long-term monitoring and damage warning of wood structures. The stress wave tomography successfully obtains images of internal defects inside tree trunks. The anchorage of some historic trees cannot be quantitatively evaluated with the pulling test if the tree is too large. GPR’s resolution and accuracy are very low, which limit its application. Theoretical research on NDT and promotion of NDT technology are still an essential part of the work in the future.
How Large-Scale Anthropogenic Activities Influence Vegetation Cover Change in China? A Review
Authors: Feng Dingrao , Fu Meichen , Sun Yiyu , Bao Wenkai , Zhang Min , Zhang Yafu , Wu Jinjin
Published: March 2021

Vegetation cover plays a key role in terrestrial ecosystem; therefore, it is important for researchers to investigate the variation and influencing factors of vegetation cover. China has experienced a large-scale vegetation cover change in recent years. We summarized the literature of vegetation cover change and revealed how large-scale anthropogenic activities influence vegetation cover change in China. Afforestation and intensification of cropland played a key role in large-scale greening. Urbanization showed a “U” shape to influence vegetation cover change. Mining and reclamation, land abandonment and land consolidation, and regional natural protection all had a unique influence on the change of vegetation cover. Indeed, the large-scale vegetation cover change was caused by interaction of anthropogenic factors and part human-driven climate change. Anthropogenic factors influenced climate change to indirectly alter the condition of plant growth. Interaction between climate change and human activities influence on vegetation cover still needs to be further investigated in the future.
Problems and Management of Acacia-Dominated Urban Forests on Man-Made Slopes in a Subtropical, High-Density City
Authors: Lee Cody H. Y. , Tang Alvin M. C. , Lai Derrick Y. F. , Tai Amos P. K. , Leung Alan S. L. , Tao Donald K. C. , Leung Felix , Leung Simon S. M. , Wu Charis , Tong Sandy C. S. , Ng Kathy T. K.
Published: March 2021

Acacia spp. are exotic tree species that have been widely planted on man-made slopes in Hong Kong since the 1960s. However, as they become mature and senescent, they may become a concern and cause various problems, including soil constraints for plant growth, decreasing provision of intended ecosystem services, declining syndromes, arrested succession, and high risk of failure. In this perspective paper, we present and discuss these problems using practical examples of Acacia-dominated urban forests on man-made roadside slopes in Hong Kong, based on a cross-disciplinary survey and a literature review. To conclude, we suggest that selective cutting, specific silvicultural operations of Acacia plantations, and the management of plantation edge and soils can be exercised, along with the planting of native species, to potentially alleviate these problems associated with mature Acacia plantations, by promoting the establishment of native forests, enhancing biodiversity, expediting succession, and providing better ecosystem services.
Investigating and Modeling of Cooperative Vehicle-to-Vehicle Safety Stopping Distance
Authors: Knowles Flanagan Steven , Tang Zuoyin , He Jianhua , Yusoff Irfan
Published: March 2021

Dedicated Short-Range Communication (DSRC) or IEEE 802.11p/OCB (Out of the Context of a Base-station) is widely considered to be a primary technology for Vehicle-to-Vehicle (V2V) communication, and it is aimed toward increasing the safety of users on the road by sharing information between one another. The requirements of DSRC are to maintain real-time communication with low latency and high reliability. In this paper, we investigate how communication can be used to improve stopping distance performance based on fieldwork results. In addition, we assess the impacts of reduced reliability, in terms of distance independent, distance dependent and density-based consecutive packet losses. A model is developed based on empirical measurements results depending on distance, data rate, and traveling speed. With this model, it is shown that cooperative V2V communications can effectively reduce reaction time and increase safety stop distance, and highlight the importance of high reliability. The obtained results can be further used for the design of cooperative V2V-based driving and safety applications.
Risk Assessment of Lead and Cadmium in Some Food Supplements Available on the Romanian Market
Authors: Mustatea Gabriel , Ungureanu Elena L. , Iorga Sorin C. , Ciotea Denisa , Popa Mona E.
Published: March 2021

Across the world, there has been an increase in the consumption of food supplements. This may be due to the perception that these dietary supplements cannot negatively affect the health of consumers in any way. However, dietary supplements may not have the expected effect. In addition, it has been shown that supplements can sometimes be chemically, physically or microbiologically contaminated, if the hygiene conditions and Hazard Analysis Critical Control Points (HACCP) plan are not fully complied with. The aim of this study was to determine the lead and cadmium content of 41 food supplements available on the Romanian market and to assess the risk to consumer health. The graphite furnace atomic absorption spectrometry (GFAAS) technique was used for sample analysis after wet mineralization of the samples. The risk assessment was determined based on Estimated Daily Intake (EDI), Target Hazard Quotient (THQ), and Carcinogenic Risk (CR) calculations. Values obtained for both lead and cadmium fall within the limits imposed by the legislation in force. Small risks associated with the consumption of these food supplements was shown, with a main recommendation being to decrease the recommended daily dose in the case of food supplements.
HSP70/DNAJ Family of Genes in the Brown Planthopper, Nilaparvata lugens: Diversity and Function
Authors: Chen Xuan , Li Ze-Dong , Li Dan-Ting , Jiang Ming-Xing , Zhang Chuan-Xi
Published: March 2021

Heat shock 70kDa proteins (HSP70s) and their cochaperones DNAJs are ubiquitous molecular chaperones, which function as the “HSP70/DNAJ machinery” in a myriad of biological processes. At present, a number of HSP70s have been classified in many species, but studies on DNAJs, especially in insects, are lacking. Here, we first systematically identified and characterized the HSP70 and DNAJ family members in the brown planthopper (BPH), Nilaparvata lugens, a destructive rice pest in Asia. A total of nine HSP70 and 31 DNAJ genes were identified in the BPH genome. Sequence and phylogenetic analyses revealed the high diversity of the NlDNAJ family. Additionally, spatio-temporal expression analysis showed that most NlHSP70 and NlDNAJ genes were highly expressed in the adult stage and gonads. Furthermore, RNA interference (RNAi) revealed that seven NlHSP70s and 10 NlDNAJs play indispensable roles in the nymphal development, oogenesis, and female fertility of N. lugens under physiological growth conditions; in addition, one HSP70 (NlHSP68) was found to be important in the thermal tolerance of eggs. Together, our results in this study shed more light on the biological roles of HSP70/DNAJ in regulating life cycle, coping with environmental stresses, and mediating the interactions within, or between, the two gene families in insects.
Basement Structure and Styles of Active Tectonic Deformation in Central Interior Alaska
Authors: Dixit Nilesh C. , Hanks Catherine
Published: March 2021

Central Interior Alaska is one of the most seismically active regions in North America, exhibiting a high concentration of intraplate earthquakes approximately 700 km away from the southern Alaska subduction zone. Seismological evidence suggests that intraplate seismicity in the region is not uniformly distributed, but concentrated in several discrete seismic zones, including the Nenana basin and the adjacent Tanana basin. Although the location and magnitude of the seismic activity in both basins are well defined by a network of seismic stations in the region, the tectonic controls on these intraplate earthquakes and the heterogeneous nature of Alaska’s continental interior remain poorly understood. We investigated the crustal structure of the Nenana and Tanana basins using available seismic reflection, aeromagnetic and gravity anomaly data, supplemented by geophysical well logs and outcrop data. We developed nine new two-dimensional forward models to delineate internal geometries and the crustal structure of Alaska’s interior. The results of our study demonstrates a strong crustal heterogeneity beneath both basins. The Tanana basin is a relatively shallow (up to 2 km) asymmetrical foreland basin with its southern, deeper side controlled by the northern foothills of the Central Alaska Range. Northeast-trending left lateral strike-slip faults within the Tanana basin are interpreted as a zone of clockwise crustal block rotation. The Nenana basin has a fundamentally different geometry. It is a deep (up to 8 km), narrow transtensional pull-apart basin that is deforming along the left-lateral Minto Fault. This study identifies two distinct modes of current tectonic deformation in Central Interior Alaska and provides a basis for modeling the interplay between intraplate stress fields and major structural features that potentially influence the generation of intraplate earthquakes in the region.
Climate Variability Indices—A Guided Tour
Authors: Norel Mateusz , Kałczyński Michał , Pińskwar Iwona , Krawiec Krzysztof , Kundzewicz Zbigniew W.
Published: March 2021

The objective of this study is to provide a comprehensive review and characterization of selected climate variability indices. While we discuss many major climate variability mechanisms, we focus on four principal modes of climate variability related to the dynamics of Earth’s oceans and their interactions with the atmosphere: the El Niño–Southern Oscillation (ENSO), North Atlantic Oscillation (NAO), Pacific Decadal Oscillation (PDO), and Atlantic Multi-decadal Oscillation (AMO). All these oscillation modes are of broad interest and considerable relevance, also in climate impact studies related to teleconnections, i.e., relationships between climate variations at distant locations. We try to decipher temporal patterns present in time series of different oscillation modes in the ocean–atmosphere system using exploratory analysis of the raw data, their structure, and properties, as well as illustrating the quasi-periodic behavior via wavelet analysis. With this contribution, we hope to help researchers in identifying and selecting data sources and climate variability indices that match their needs.
Mental Strength and Challenges among Thai Medical Students in Their Clinical Years—Study Protocol
Authors: Hiranwong Tanrin , Sitthiprawiat Patipan , Siritikul Sirinut , Jiwtrakul Jiraphat , Klaychaiya Sirilux , Chaipinchana Pookit , Kuntawong Pimolpun , Wongpakaran Tinakon , Wongpakaran Nahathai , Deesomchok Athavudh , Wedding Danny
Published: March 2021

(1) Background: Mental well-being and mental health problems are both important, especially among medical students who will be future doctors. The proposed study aimed to explore both positive and negative mental health experiences, especially mistreatment, occurring among medical students in their clinical years. (2) Methods/design: The study will conduct a cross-sectional survey between January 2021 and December 2021, among medical students studying in their clinical years across 23 medical schools throughout Thailand. Measurements regarding character strengths related to medical professionalism as well as other positive mental health strengths and negative mental health problems, e.g., anxiety, depression and experience of mistreatment will be completed. Both medical students and faculty members will be invited to participate in the study. (3) Discussion: this survey will provide an overall picture of medical students’ mental well-being, positive and negative aspects of mental health and the magnitude of mistreatment and perspectives they experience. The limitations of the survey will be discussed.
Changes in Physical Activity among United Kingdom University Students Following the Implementation of Coronavirus Lockdown Measures
Authors: Wickersham Alice , Carr Ewan , Hunt Ryan , Davis Jordan P. , Hotopf Matthew , Fear Nicola T. , Downs Johnny , Leightley Daniel
Published: March 2021

Coronavirus disease (COVID-19) and resulting restrictions have significantly impacted physical activity levels. However, objectively measured changes in physical activity levels among UK university students during lockdown are understudied. Using data collected via remote measurement technology from a mobile physical activity tracker, this study aimed to describe the longitudinal trajectories of physical activity following the start of lockdown among students at a large UK university, and to investigate whether these trajectories varied according to age, gender, and ethnicity. Continuous physical activity data for steps walked per week (n = 730) and miles run per week (n = 264) were analysed over the first period of lockdown and subsequent restriction easing using negative binomial mixed models for repeated measures. Throughout the observation period, more steps were walked by males compared to females, and by White groups compared to all other ethnic groups combined. However, there was a gradual increase in the number of steps walked per week following the commencement of lockdown, irrespective of sociodemographic characteristics. For females only, there was a decrease in the number of miles run per week following lockdown. The long-term impact of the pandemic on physical health is unknown, but our results highlight changes in physical activity which could have implications for physical health.
Chloride Removal of Calcium Aluminate-Layered Double Hydroxide Phases: A Review
Authors: Kim Gwangmok , Park Sangwon
Published: March 2021

Chlorine is a critical element with respect to the use of fossil fuel, recycling of industrial wastes, and water purification. Chlorine could form toxic chemical compounds, corrode pipe systems and boilers, and contaminate surface and ground waters. Calcium aluminate-layered double hydroxides are one of the most promising materials to remove chlorides due to the chemisorption mechanism, since the phases have positively charged interlayers. Many studies on the synthesis and the characterization of calcium aluminate-layered double hydroxides have been extensively conducted, whereas few studies have been conducted on the chloride removal characteristics of the phases. The state-of-the-art studies on the synthesis methods and the structural characteristics of CaAl-LDH phases, the underlying mechanism on the removal of chlorides, and the potential removal rate and the capacity in the present study were thoroughly reviewed.
A Data Envelopment Analysis of the Impact of European Funds on Environmental Indicators
Authors: Ferasso Marcos , Blanco Miguel , Bares Lydia
Published: March 2021

The European Union (EU) has launched two regional investment programs of European Funds (FE) in the last decade. One covers the period of 2007 to 2013, and the second from 2014 to 2020. Among the goals contained in FE regulations is that of achieving sustainable growth through the conversion of fossil energy production systems to renewable energy. This research has had a goal to determine whether the countries of the Eurozone maintain homogeneous levels of efficiency in the use of these resources to improve the levels of environmental quality related to the use of this type of energy. The adopted research method for efficiency analyses was Data Envelopment Analysis (DEA). Findings revealed that the efficiency in the use of renewable energies is very uneven among the analyzed countries and that these differences are maintained throughout the analyzed period. These results suggest that the criteria for the distribution of the funds should be modified. The current distribution is mainly based on the per capita income of the countries and/or regions. In this way, compliance with the European Green Pact approved in September 2020 would be guaranteed.
Effects of Lifestyle Changes on the Mental Health of Healthcare Workers with Different Sense of Coherence Levels in the Era of COVID-19 Pandemic
Authors: Tanaka Kento , Tahara Masatoshi , Mashizume Yuki , Takahashi Kayoko
Published: March 2021

Sense of coherence (SOC) is a psychological factor that contributes to mental health maintenance under stressful environment. Likewise, level of SOC might affect mental health among healthcare workers during the COVID-19 pandemic differently. In this study, we investigated the relationships between lifestyle changes and mental health (General Health Questionnaire-12: GHQ-12) among different level of SOC (weak, moderate, or strong by SOC-13). The data of 898 healthcare workers from cross-sectional survey dataset were extracted and analyzed. As results, based on GHQ-12 score, 86.1% of 244 participants with weak SOC, 60.1% of 606 participants with moderate SOC, and 31.3% of 48 participants with strong SOC had poor mental health. Both SOC levels and lifestyle changes (except alcohol consumption) had significant main effects on the GHQ-12 score. Analysis on the association between lifestyle changes and mental health status stratified by SOC level reveled that among participants with weak SOC, those who increased their leisure and activity time had reduced odds of poor mental health than those who made no changes (OR: 0.08, CI: 0.01 to 0.64). Healthcare workers with weak SOC were at risk of poor mental health during the COVID-19 pandemic, and lifestyle changes may improve their mental health.
Greenspace Interventions, Stress and Cortisol: A Scoping Review
Authors: Jones Reo , Tarter Robin , Ross Amy Miner
Published: March 2021

Background: Engaging with nature can profoundly impact psychological and physiological health of persons across the lifespan. Greenspace interventions (GSI) encompass a broad range of strategic, nature-based activities for overall health and wellbeing. Within the past 20 years there has been a growing interest in the access to and management of greenspace to mediate the deleterious impact of acute and chronic stress, particularly, physiologic biomarkers of stress such as cortisol. Objective: This review aims to describe the impact of greenspace interventions on cortisol, to present the current state of the science on GSIs as they impact cortisol, and to uncover any limitations of current research strategies to best inform future research. Methods: A scoping methodology was conducted to systematically study this emerging field and inform future research by mapping the literature based on the GSI category, interventional design, cortisol metrics, and subsequent analysis of cortisol. Conclusion: Considerable heterogeneity in research design, aim(s), interventional strategy, and cortisol metrics were identified from a total of 18 studies on GSIs and cortisol outcomes. While studies demonstrated a potential for the positive association between GSIs and stress relief, more rigorous research is needed to represent GSIs as an intervention to mitigate risks of stress.
Benefits of a Low-Cost Walking Device in Children with Cerebral Palsy: A Qualitative Study
Authors: Rodríguez-Costa Isabel , De la Cruz-López Irene , Fernández-Zárate Ignacio , Maldonado-Bascón Saturnino , Lafuente-Arroyo Sergio , Nunez-Nagy Susana
Published: March 2021

Children with Cerebral Palsy (CP) participate less regularly in physical and social activities. Support walkers allow mobility for infants who need aid. The aim of this study is to explore the benefits of a low-cost walking device in children with CP. A qualitative study using semi-structured, face-to-face interviews was conducted. Eight participants (two parents, two educational professionals, and four physical therapists) who live or work with children with CP that use a low-cost walking device were questioned to examine the benefits of the practice. Thematic analysis denoted three key factors about the benefits: emotional welfare, physical wellbeing, and social enjoyment. To conclude, the use of a support walker in children with CP makes them feel happier, improves their self-confidence and autonomy, and promotes participation.
Comment on Alley, S.J., et al. As the Pandemic Progresses, How Does Willingness to Vaccinate against COVID-19 Evolve? Int. J. Environ. Res. Public Health 2021, 18, 797
Authors: Weitzer Jakob , Laubichler Manfred D. , Birmann Brenda M. , Bertau Martin , Zenk Lukas , Caniglia Guido , Jäger Carlo C. , Steiner Gerald , Schernhammer Eva
Published: March 2021

We would like to extend on the article by Alley et al [...]
Effects of Virtual Reality-Based Therapy on Quality of Life of Patients with Subacute Stroke: A Three-Month Follow-Up Randomized Controlled Trial
Authors: Rodríguez-Hernández Marta , Criado-Álvarez Juan-José , Corregidor-Sánchez Ana-Isabel , Martín-Conty José L. , Mohedano-Moriano Alicia , Polonio-López Begoña
Published: March 2021

Objective: To evaluate the influence of conventional rehabilitation combined with virtual reality on improving quality of life related to post-stroke health. Design: Randomized controlled trial. Setting: Rehabilitation and neurology departments of a general hospital (Talavera de la Reina, Spain). Subjects: A total of 43 participants with subacute stroke. Intervention: Participants were randomized into experimental group (conventional treatment + virtual reality) and control (conventional treatment). Main measures: Health-related quality of life as measured by the EuroQoL-5 dimensions instrument (EQ-5D-5L) and EuroQoL visual analog scale (EQ-VAS). Results: A total of 23 patients in the experimental group (62.6 ± 13.5 years) and 20 in the control (63.6 ± 12.2 years) completed the study. In the experimental group, EQ-VAS score was 29.1 ± 12.8 at baseline, 86.5 ± 7.1 post-intervention, and 78.3 ± 10.3 at the three-month follow-up. The control group obtained scores of 25.5 ± 5.1, 57.0 ± 4.7, and 58.5 ± 5.9, respectively. We identified significant differences at the post-intervention and follow-up timepoints (p = 0.000) and a partial η2 of 0.647. In EQ-5D-5L, the severity of issues decreased after intervention in the experimental group, while pain and anxiety dimensions increased between post-intervention and follow-up. Conclusions: The conventional rehabilitative approach combined with virtual reality appears to be more effective for improving the perceived health-related quality of life in stroke survivors.
Highlights of Current Dietary Guidelines in Five Continents
Authors: Fernandez Maria Luz , Raheem Dele , Ramos Fernando , Carrascosa Conrado , Saraiva Ariana , Raposo António
Published: March 2021

The dietary guidelines as well as the organizations that establish the recommendations are not homogeneous across regions of the world. Each country utilizes specific icons to better describe to the public easy ways to follow specific recommendations, including the use of pyramids, plates, and other forms of presenting key information. All dietary guidelines are updated within certain periods to ensure that new findings or specific changes are communicated to the public. The purpose of this commentary is to describe the most updated information as well as some history on how these symbols are utilized in different countries or areas of the world. The updated Mediterranean pyramid as well as MyPlate and the Pyramids utilized in South Africa, Japan, and Argentina are discussed in this commentary.
Association between Viral Infections and Risk of Autistic Disorder: An Overview
Authors: Shuid Ahmad Naqib , Jayusman Putri Ayu , Shuid Nazrun , Ismail Juriza , Kamal Nor Norazlin , Mohamed Isa Naina
Published: March 2021

Autism spectrum disorder (ASD) is a neurodevelopmental condition of the central nervous system (CNS) that presents with severe communication problems, impairment of social interactions, and stereotypic behaviours. Emerging studies indicate possible associations between viral infections and neurodegenerative and neurobehavioural conditions including autism. Viral infection during critical periods of early in utero neurodevelopment may lead to increased risk of autism in the offspring. This review is aimed at highlighting the association between viral infections, including viruses similar to COVID-19, and the aetiology of autism. A literature search was conducted using Pubmed, Ovid/Medline, and Google Scholar database. Relevant search terms included “rubella and autism”, “cytomegalovirus and autism”, “influenza virus and autism”, “Zika virus and autism”, “COVID-19 and autism”. Based on the search terms, a total of 141 articles were obtained and studies on infants or children with congenital or perinatal viral infection and autistic behaviour were evaluated. The possible mechanisms by which viral infections could lead to autism include direct teratogenic effects and indirect effects of inflammation or maternal immune activation on the developing brain. Brain imaging studies have shown that the ensuing immune response from these viral infections could lead to disruption of the development of brain regions and structures. Hence, long-term follow up is necessary for infants whose mothers report an inflammatory event due to viral infection at any time during pregnancy to monitor for signs of autism. Research into the role of viral infection in the development of ASD may be one avenue of improving ASD outcomes in the future. Early screening and diagnosis to detect, and maybe even prevent ASD are essential to reduce the burden of this condition.
Rural–Urban Differences in the Factors Affecting Depressive Symptoms among Older Adults of Two Regions in Myanmar
Authors: Sasaki Yuri , Shobugawa Yugo , Nozaki Ikuma , Takagi Daisuke , Nagamine Yuiko , Funato Masafumi , Chihara Yuki , Shirakura Yuki , Lwin Kay Thi , Zin Poe Ei , Bo Thae Zarchi , Sone Tomofumi , Win Hla Hla
Published: March 2021

The aim of the study was to investigate rural–urban differences in depressive symptoms in terms of the risk factors among older adults of two regions in Myanmar to provide appropriate intervention for depression depending on local characteristics. This cross-sectional study, conducted between September and December, 2018, used a multistage sampling method to recruit participants from the two regions, for face-to-face interviews. Depressive symptoms were assessed using the 15-item version of the Geriatric Depression Scale (GDS). Depressive symptoms were positively associated with living in rural areas (B = 0.42; 95% confidence interval (CI): 0.12,0.72), female (B = 0.55; 95% CI: 0.31,0.79), illness during the preceding year (B = 0.68; 95% CI: 0.45,0.91) and non-Buddhist religion (B = 0.57; 95% CI: 0.001,1.15) and protectively associated with education to middle school level or higher (B = −0.61; 95% CI: −0.94, −0.28) and the frequency of visits to religious facilities (B = −0.20; 95% CI: −0.30, −0.10). In women in urban areas, depressive symptoms were positively associated with illness during the preceding year (B = 0.78; 95% CI: 0.36, 1.20) and protectively associated with education to middle school level or higher (B = −0.67; 95% CI: −1.23, −0.11), middle or high wealth index (B = −0.92; 95% CI: −1.59, −0.25) and the frequency of visits to religious facilities (B = −0.20; 95% CI: −0.38, −0.03). In men in rural areas, illness during the preceding year was positively associated with depressive symptoms (B = 0.87; 95% CI: 0.33, 1.42). In women in rural areas, depressive symptoms were positively associated with illness during the preceding year (B = 0.83; 95% CI: 0.36, 1.30) and protectively associated with primary education (B = −0.62; 95% CI: −1.12, −0.12) and the frequency of visits to religious facilities (B = −0.44; 95% CI: −0.68, −0.21). Religion and wealth could have different levels of association with depression between older adults in the urban and rural areas and men and women. Interventions for depression in older adults should consider regional and gender differences in the roles of religion and wealth in Myanmar.
Reduction of Human Mobility Matters during Early COVID-19 Outbreaks: Evidence from India, Japan and China
Authors: Ren Zhehao , Li Ruiyun , Zhang Tao , Chen Bin , Wang Che , Li Miao , Song Shuang , Xiao Yixiong , Xu Bo , Liu Zhaoyang , Shen Chong , Guan Dabo , Hou Lin , Deng Ke , Bai Yuqi , Gong Peng , Xu Bing
Published: March 2021

Mobility restrictions have been a heated topic during the global pandemic of coronavirus disease 2019 (COVID-19). However, multiple recent findings have verified its importance in blocking virus spread. Evidence on the association between mobility, cases imported from abroad and local medical resource supplies is limited. To reveal the association, this study quantified the importance of inter- and intra-country mobility in containing virus spread and avoiding hospitalizations during early stages of COVID-19 outbreaks in India, Japan, and China. We calculated the time-varying reproductive number (Rt) and duration from illness onset to diagnosis confirmation (Doc), to represent conditions of virus spread and hospital bed shortages, respectively. Results showed that inter-country mobility fluctuation could explain 80%, 35%, and 12% of the variance in imported cases and could prevent 20 million, 5 million, and 40 million imported cases in India, Japan and China, respectively. The critical time for screening and monitoring of imported cases is 2 weeks at minimum and 4 weeks at maximum, according to the time when the Pearson’s Rs between Rt and imported cases reaches a peak (>0.8). We also found that if local transmission is initiated, a 1% increase in intra-country mobility would result in 1430 (±501), 109 (±181), and 10 (±1) additional bed shortages, as estimated using the Doc in India, Japan, and China, respectively. Our findings provide vital reference for governments to tailor their pre-vaccination policies regarding mobility, especially during future epidemic waves of COVID-19 or similar severe epidemic outbreaks.
Challenges to Evidence Synthesis and Identification of Data Gaps in Human Biomonitoring
Authors: Virgolino Ana , Santos Osvaldo , Costa Joana , Fialho Mónica , Iavicoli Ivo , Santonen Tiina , Tolonen Hanna , Samoli Evangelia , Katsouyanni Klea , Baltatzis Georgios , Ruggieri Flavia , Abballe Annalisa , Petrovičová Ida , Kolena Branislav , Šidlovská Miroslava , Ancona Carla , Eržen Ivan , Sepai Ovnair , Castaño Argelia , Kolossa-Gehring Marike , Fiddicke Ulrike
Published: March 2021

The increasing number of human biomonitoring (HBM) studies undertaken in recent decades has brought to light the need to harmonise procedures along all phases of the study, including sampling, data collection and analytical methods to allow data comparability. The first steps towards harmonisation are the identification and collation of HBM methodological information of existing studies and data gaps. Systematic literature reviews and meta-analyses have been traditionally put at the top of the hierarchy of evidence, being increasingly applied to map available evidence on health risks linked to exposure to chemicals. However, these methods mainly capture peer-reviewed articles, failing to comprehensively identify other important, unpublished sources of information that are pivotal to gather a complete map of the produced evidence in the area of HBM. Within the framework of the European Human Biomonitoring Initiative (HBM4EU) initiative—a project that joins 30 countries, 29 from Europe plus Israel, the European Environment Agency and the European Commission—a comprehensive work of data triangulation has been made to identify existing HBM studies and data gaps across countries within the consortium. The use of documentary analysis together with an up-to-date platform to fulfil this need and its implications for research and practice are discussed.
The Impact of COVID-19 on Crime: A Spatial Temporal Analysis in Chicago
Authors: Yang Mengjie , Chen Zhe , Zhou Mengjie , Liang Xiaojin , Bai Ziyue
Published: March 2021

The coronavirus disease 2019 (COVID-19) pandemic has had tremendous and extensive impacts on the people’s daily activities. In Chicago, the numbers of crime fell considerably. This work aims to investigate the impacts that COVID-19 has had on the spatial and temporal patterns of crime in Chicago through spatial and temporal crime analyses approaches. The Seasonal-Trend decomposition procedure based on Loess (STL) was used to identify the temporal trends of different crimes, detect the outliers of crime events, and examine the periodic variations of crime distributions. The results showed a certain phase pattern in the trend components of assault, battery, fraud, and theft. The largest outlier occurred on 31 May 2020 in the remainder components of burglary, criminal damage, and robbery. The spatial point pattern test (SPPT) was used to detect the similarity between the spatial distribution patterns of crime in 2020 and those in 2019, 2018, 2017, and 2016, and to analyze the local changes in crime on a micro scale. It was found that the distributions of crime significantly changed in 2020 and local changes in theft, battery, burglary, and fraud displayed an aggregative cluster downtown. The results all claim that spatial and temporal patterns of crime changed significantly affected by COVID-19 in Chicago, and they offer constructive suggestions for local police departments or authorities to allocate their available resources in response to crime.
Development after Displacement: Evaluating the Utility of OpenStreetMap Data for Monitoring Sustainable Development Goal Progress in Refugee Settlements
Authors: Van Den Hoek Jamon , Friedrich Hannah K. , Ballasiotes Anna , Peters Laura E. R. , Wrathall David
Published: March 2021

In 2015, 193 countries declared their commitment to “leave no one behind” in pursuit of 17 Sustainable Development Goals (SDGs). However, the world’s refugees have been routinely excluded from national censuses and representative surveys, and, as a result, have broadly been overlooked in SDG evaluations. In this study, we examine the potential of OpenStreetMap (OSM) data for monitoring SDG progress in refugee settlements. We collected all available OSM data in 28 refugee and 26 nearby non-refugee settlements in the major refugee-hosting country of Uganda. We created a novel SDG-OSM data model, measured the spatial and temporal coverages of SDG-relevant OSM data across refugee settlements, and compared these results to non-refugee settlements. We found 11 different SDGs represented across 92% (21,950) of OSM data in refugee settlements, compared to 78% (1919 nodes) in non-refugee settlements. However, most data were created three years after refugee arrival, and 81% of OSM data in refugee settlements were never edited, both of which limit the potential for long-term monitoring of SDG progress. In light of our findings, we offer suggestions for improving OSM-driven SDG monitoring in refugee settlements that have relevance for development and humanitarian practitioners and research communities alike.
Understanding Users’ Satisfaction towards Public Transit System in India: A Case-Study of Mumbai
Authors: Das Rahul Deb
Published: March 2021

In this work, we present a novel approach to understand the quality of public transit system in resource constrained regions using user-generated contents. With growing urban population, it is getting difficult to manage travel demand in an effective way. This problem is more prevalent in developing cities due to lack of budget and proper surveillance system. Due to resource constraints, developing cities have limited infrastructure to monitor transport services. To improve the quality and patronage of public transit system, authorities often use manual travel surveys. But manual surveys often suffer from quality issues. For example, respondents may not provide all the detailed travel information in a manual travel survey. The survey may have sampling bias. Due to close-ended design (specific questions in the questionnaire), lots of relevant information may not be captured in a manual survey process. To address these issues, we investigated if user-generated contents, for example, Twitter data, can be used to understand service quality in Greater Mumbai in India, which can complement existing manual survey process. To do this, we assumed that, if a tweet is relevant to public transport system and contains negative sentiment, then that tweet expresses user’s dissatisfaction towards the public transport service. Since most of the tweets do not have any explicit geolocation, we also presented a model that does not only extract users’ dissatisfaction towards public transit system but also retrieves the spatial context of dissatisfaction and the potential causes that affect the service quality. It is observed that a Random Forest-based model outperforms other machine learning models, while yielding 0.97 precision and 0.88 F1-score.
Evolution as a Guide to Designing xeno Amino Acid Alphabets
Authors: Mayer-Bacon Christopher , Agboha Neyiasuo , Muscalli Mickey , Freeland Stephen
Published: March 2021

Here, we summarize a line of remarkably simple, theoretical research to better understand the chemical logic by which life’s standard alphabet of 20 genetically encoded amino acids evolved. The connection to the theme of this Special Issue, “Protein Structure Analysis and Prediction with Statistical Scoring Functions”, emerges from the ways in which current bioinformatics currently lacks empirical science when it comes to xenoproteins composed largely or entirely of amino acids from beyond the standard genetic code. Our intent is to present new perspectives on existing data from two different frontiers in order to suggest fresh ways in which their findings complement one another. These frontiers are origins/astrobiology research into the emergence of the standard amino acid alphabet, and empirical xenoprotein synthesis.
Therapeutic Advances in Diabetes, Autoimmune, and Neurological Diseases
Authors: Liu Jinsha , Ting Joey Paolo , Al-Azzam Shams , Ding Yun , Afshar Sepideh
Published: March 2021

Since 2015, 170 small molecules, 60 antibody-based entities, 12 peptides, and 15 gene- or cell-therapies have been approved by FDA for diverse disease indications. Recent advancement in medicine is facilitated by identification of new targets and mechanisms of actions, advancement in discovery and development platforms, and the emergence of novel technologies. Early disease detection, precision intervention, and personalized treatments have revolutionized patient care in the last decade. In this review, we provide a comprehensive overview of current and emerging therapeutic modalities developed in the recent years. We focus on nine diseases in three major therapeutics areas, diabetes, autoimmune, and neurological disorders. The pathogenesis of each disease at physiological and molecular levels is discussed and recently approved drugs as well as drugs in the clinic are presented.
Bridging Ride and Play Comfort
Authors: Zhang Zeliang , Xiaohan Kang , Khalid Mohd Nor Akmal , Iida Hiroyuki
Published: March 2021

The notion of comfort with respect to rides, such as roller coasters, is typically addressed from the perspective of a physical ride, where the convenience of transportation is redefined to minimize risk and maximize thrill. As a popular form of entertainment, roller coasters sit at the nexus of rides and games, providing a suitable environment to measure both mental and physical experiences of rider comfort. In this paper, the way risk and comfort affect such experiences is investigated, and the connection between play comfort and ride comfort is explored. A roller coaster ride simulation is adopted as the target environment for this research, which combines the feeling of being thrill and comfort simultaneously. At the same time, this paper also expands research on roller coaster rides while bridging the rides and games via the analogy of the law of physics, a concept currently known as motion in mind. This study’s contribution involves a roller coaster ride model, which provides an extended understanding of the relationship between physical performance and the mental experience relative to the concept of motion in mind while establishing critical criteria for a comfortable experience of both the ride and play.
Peeling the Layers of Caddisfly Diversity on a Longitudinal Gradient in Karst Freshwater Habitats Reveals Community Dynamics and Stability
Authors: Pozojević Ivana , Ivković Marija , Cetinić Katarina Ana , Previšić Ana
Published: March 2021

Freshwater biodiversity is facing a severe crisis due to many human impacts, yet the diversity dynamics of freshwater communities and possibilities of assessing these are vastly unexplored. We aimed at emphasizing different aspects of portraying diversity of a species-rich, aquatic insect group (caddisflies; Trichoptera) across four different habitats in an anthropogenically unimpacted, connected karst barrage lake/riverine system. To define diversity, we used common indices with pre-set sensitivity to species abundance/dominance; i.e., sensitivity parameter (species richness, Shannon, Simpson, Berger-Parker) and diversity profiles based on continuous gradients of this sensitivity parameter: the naïve and non-naïve diversity profiles developed by Leinster and Cobbold. The non-naïve diversity profiles show diversity profiles with regard to the similarity among species in terms of ecological traits and preferences, whereas the naïve diversity profile is called mathematically “naïve” as it assumes absolute dissimilarity between species that is almost never true. The commonly used indices and the naïve diversity profile both ranked the springs as least diverse and tufa barriers as most diverse. The non-naïve diversity profiles based on similarity matrices (using feeding behavior and stream zonation preferences of species), showed even greater differences between these habitats, while ranking stream habitats close together, regardless of their longitudinal position. We constructed the Climate Score index (CSI) in order to assess how diversity and species’ vulnerability project the community’s resistance and/or resilience to climate change. The CSI ranked the springs as most vulnerable, followed by all habitats longitudinally placed below them. We highlight the importance of integrating ecological information into biodiversity and vulnerability assessment of freshwater communities.
Effects of Hyperbaric Oxygen Therapy in Children with Severe Atopic Dermatitis
Authors: Mews Judyta , Tomaszewska Agata , Siewiera Jacek , Lewicki Sławomir , Kuczborska Karolina , Lipińska-Opałka Agnieszka , Kalicki Bolesław
Published: March 2021

In the course of atopic dermatitis (AD), the overactivity of the immune system, associated with predominant Th2 lymphocyte responses, is observed, which leads to an increased inflammatory reaction. Cases of a severe course of atopic dermatitis lead to the search for new therapeutic options. The aim of this study was to assess the effects of hyperbaric oxygen therapy (HBOT) treatment for severe cases of AD in children. A total of 15 children with severe AD underwent therapy. The influence of HBOT on the clinical course of AD and immunomodulatory effect of the therapy was analyzed by the SCORAD and objective SCORAD (oSCORAD) scales and by determining the serum concentration of immunological parameters (blood: nTreg lymphocytes, CD4+CD25highCD127-FOXP3+, NKT lymphocytes CD3+, CD16/56+, and serum: total IgE, cytokines IL-4, IL-6, and IL-10, before and after the 30-day treatment cycle). The study showed a significant effect of the therapy on the improvement of the skin condition. In all children, a reduction in the extent and intensity of skin lesions, reduction of redness, swelling, oozing/crusting, scratch marks and skin lichenification after HBOT was observed. Patients also reported a reduction in the intensity of pruritus and an improvement in sleep quality after therapy. In all children, a statistically significant decrease in the serum level of IgE was observed. However, no statistically significant changes in the blood levels of IL-4, IL-6 and IL-10, as well as the percentage of CD4+CD25highCD127−FOXP3+ Treg and NKT lymphocytes, were found. In conclusion, the use of hyperbaric therapy has a positive impact on treatment results in children with a severe course of atopic dermatitis.
Characteristics and Detection Rate of SARS-CoV-2 in Alternative Sites and Specimens Pertaining to Dental Practice: An Evidence Summary
Authors: Shirazi Sajjad , Stanford Clark M. , Cooper Lyndon F.
Published: March 2021

Knowledge about the detection potential and detection rates of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in various body fluids and sites is important for dentists since they, directly or indirectly, deal with many of these fluids/sites in their daily practices. In this study, we attempt to review the latest evidence and meta-analysis studies regarding the detection rate of SARS-CoV-2 in different body specimens and sites as well as the characteristics of these sample. The presence/detection of SARS-CoV-2 viral biomolecules (nucleic acid, antigens, antibody) in different clinical specimens depends greatly on the specimen type and timing of collection. These specimens/sites include nasopharynx, oropharynx, nose, saliva, sputum, bronchoalveolar lavage, stool, urine, ocular fluid, serum, plasma and whole blood. The relative detection rate of SARS-CoV-2 viral biomolecules in each of these specimens/sites is reviewed in detail within the text. The infectious potential of these specimens depends mainly on the time of specimen collection and the presence of live replicating viral particles.