bluuebunny/crossref_metadata_2025 huggingface dataset:
Mental Fatigue, But Not other Fatigue Characteristics, as a Candidate Feature of Obsessive Compulsive Personality Disorder in Patients with Anxiety and Mood Disorders—An Exploratory Study
Authors: Gecaite-Stonciene Julija , Fineberg Naomi A. , Podlipskyte Aurelija , Neverauskas Julius , Juskiene Alicja , Mickuviene Narseta , Burkauskas Julius
Published: November 2020

Background: Obsessive compulsive personality disorder (OCPD) is commonly associated with anxiety and mood disorders (AMDs), in which fatigue and executive dysfunction represent key symptoms. Executive dysfunction has also been demonstrated in subjects with OCPD, and is additionally found to be a cardinal feature of fatigue. This study aimed to investigate the associations between fatigue, executive dysfunction, and OCPD in patients with AMDs. Methods: In this cross-sectional study, 85 AMD patients (78% females, mean age 39 ± 11 years) were evaluated for OCPD traits by using the observer-rated Compulsive Personality Assessment Scale. The Multidimensional Fatigue Inventory-20 was used to measure different aspects of fatigue, and the Trail Making Test was employed to assess executive functioning. The Hamilton rating scales were used to evaluate anxiety and depression symptoms. Results: Controlling for potential confounders, there was a significant link between OCPD and mental fatigue (OR, 1.27; 95% CI, 1.02 to 1.58; p = 0.033). No associations were found between the presence of OCPD and other relevant fatigue characteristics, including general fatigue, physical fatigue, reduced activity, and reduced motivation, as well as executive functions. Conclusions: To the best of our knowledge, this study is the first to report associations between OCPD and mental fatigue in patients with AMDs, suggesting mental fatigue as a clinically important symptom when considering particular personality pathologies.
Prevalence of Eating Disorder Risk and Body Image Dissatisfaction among ROTC Cadets
Authors: Smith Allison , Emerson Dawn , Winkelmann Zachary , Potter Devin , Torres-McGehee Toni
Published: November 2020

Injury risk is multifactorial including non-modifiable and modifiable factors such as nutrition and mental health. The purpose of this study was to estimate eating disorder risk and body image (BI) dissatisfaction among Reserve Officers Training Corps (ROTC) cadets. A total of 102 (male: n = 75, female: n = 27; age: 20 ± 2 years) ROTC cadets self-reported height, current and ideal weight, and completed the Eating Attitudes Test-26 (EAT-26) and self-perceived BI current and perceived sex-specific figural stimuli. The overall eating disorder risk for ROTC cadets was 32.4%. No significant differences were found when comparing sex, ethnicity, or military branch. Overall risk of pathogenic behaviors included 11.8% who reported binge eating; 8.8% who used laxatives, diuretics, or diet pills; 8.8% who exercised for >60 min to control their weight; and 8.8% who lost 9.1 kg or more within the last 6 months. We identified significant interactions (p ≤ 0.01) between sex of the solider, overall perceptions of male and female soldiers, and BI self-perceptions. The ROTC cadets in this study displayed eating disorder risk and BI dissatisfaction, which is concerning for tactical readiness, long-term behavioral health issues, and injury from pathogenic behaviors. Education and quality healthcare are necessary to mitigate the increased risk of eating and BI dissatisfaction within this population.
Developing a National Research Agenda to Support Healthy Food Retail
Authors: Hecht Amelie A. , Lott Megan M. , Arm Kirsten , Story Mary T. , Snyder Emily , Wootan Margo G. , Moran Alyssa J.
Published: November 2020

The food retail environment is an important driver of dietary choices. This article presents a national agenda for research in food retail, with the goal of identifying policies and corporate practices that effectively promote healthy food and beverage purchases and decrease unhealthy purchases. The research agenda was developed through a multi-step process that included (1) convening a scientific advisory committee; (2) commissioned research; (3) in-person expert convening; (4) thematic analysis of meeting notes and refining research questions; (5) follow-up survey of convening participants; and (6) refining the final research agenda. Public health researchers, advocates, food and beverage retailers, and funders participated in the agenda setting process. A total of 37 research questions grouped into ten priority areas emerged. Five priority areas focus on understanding the current food retail environment and consumer behavior and five focus on assessing implementation and effectiveness of interventions and policies to attain healthier retail. Priority topics include how frequency, duration, and impact of retailer promotion practices differ by community characteristics and how to leverage federal nutrition assistance programs to support healthy eating. To improve feasibility, researchers should explore partnerships with retailers and advocacy groups, identify novel data sources, and use a variety of study designs. This agenda can serve as a guide for researchers, food retailers, funders, government agencies, and advocacy organizations.
Myth Acceptance Regarding Male-To-Female Intimate Partner Violence amongst Spanish Adolescents and Emerging Adults
Authors: Del Moral Gonzalo , Franco Cosette , Cenizo Manuel , Canestrari Carla , Suárez-Relinque Cristian , Muzi Morena , Fermani Alessandra
Published: November 2020

(1) Background: General beliefs and attitudes toward Male-to-Female Intimate Partner Violence (MFIPV) play a fundamental, critical role in the expression of violent behaviors in relationships during both adolescence and adulthood. The objective of the present study was to contrast the degree of myth acceptance regarding MFIPV, based on the sex and age of Spanish teenagers and emerging adults. (2) Methods: A sample of 1580 participants aged between 15 and 24 took part in the study. The subjects were enrolled in 34 secondary schools and two university centers spread across Seville (Spain). A multivariate analysis of variance (MANOVA) was carried out for the data analysis. (3) Results: Overall, males had a higher level of myth acceptance than females in all the dimensions considered in the study. In the case of significantly high levels of myth acceptance, males quintupled females. The research dimension that revealed the greatest differences was romantic love. Regarding age, a degree of stability was observed in the age period of 15–17 years and 18–20 years, but this subsequently decreased for the age range of 21–24 years. (4) Conclusions: Efforts should be focused on promoting actions to challenge male mandates and narratives concerning romantic or true love.
A Health Guidance App to Improve Motivation, Adherence to Lifestyle Changes and Indicators of Metabolic Disturbances among Japanese Civil Servants
Authors: Takeyama Naoko , Moriyama Michiko , Kazawa Kana , Steenkamp Malinda , Rahman Md Moshiur
Published: November 2020

We investigated whether an Information and Communication Technology (ICT) application (app) motivated to increase adherence to lifestyle changes, and to improve indicators of metabolic disturbances among Japanese civil servants. A non-randomized, open-label, parallel-group study was conducted with 102 participants aged 20–65 years undergoing a health check during 2016–2017, having overweight and/or elevated glucose concentration. Among them, 63 participants chose Specific Health Guidance (SHG) and ongoing support incorporating the use of an app (ICT group) and 39 individuals chose only SHG (control group). Fifty from the ICT group and 38 from the control group completed the study. After completing the 6-month program, the control group showed a significant decrease in body mass index (p = 0.008), male waist circumference (p < 0.001), systolic blood pressure (BP) (p = 0.005), diastolic BP (p < 0.001), and glycated hemoglobin (HbA1c) (p < 0.001), and increase in high-density lipoprotein (HDL) cholesterol (p = 0.008). However, the ICT group showed a significant decrease in male waist circumference (p < 0.001), diastolic BP (p = 0.003), and HbA1c (p < 0.001), and increase in HDL cholesterol (p = 0.032). The magnitude of change for most indicators tended to be highest for ICT participants (used the app ≥5 times/month). Both groups reported raised awareness on BP and weight. The app use program did not have a major impact after the observation period. Proper action requires frequent use of the app to enhance best results.
Developing and Testing a Scale Designed to Measure Perceived Phubbing
Authors: David Meredith E. , Roberts James A.
Published: November 2020

Phubbing (phone snubbing) has become a commonplace behavior. The more we are phubbed the more likely we are to phub others. The extraordinary attention-grabbing ability of the smartphone would only be an interesting story if not for its impact on social media use and, ultimately, stress and depression. In Study 1 (n = 258, Mage = 20), we develop a parsimonious and valid measure of phubbing. Extant “phubbing” measures all lack important qualities needed to be able to assess phubbing with a brief and valid scale that can be replicated and used in a variety of research settings. In Study 2 (n = 157, Mage = 39), we test and extend the David and Roberts (2017) phubbing model, while further validating our perceived phubbing measure. We use Social Exchange Theory and Kardefelt-Winther’s (2014) model of compensatory internet use as theoretical support for our expected findings. Results find that phubbed individuals experience a sense of social exclusion that, paradoxically, is associated with an increased use of social media. This increased use of social media is associated with higher reported levels of anxiety and depression. Future research directions and study limitations are discussed.
Availability, Promotion, and Signs of Alcohol Consumption: A Mixed Methods Study of Perceived Exposure and Objective Measures
Authors: Pastor Andrea , de la Fuente Irene Molina , Sandín Vázquez María , Conde Paloma , Bosque-Prous Marina , Franco Manuel , Shortt Niamh , Sureda Xisca
Published: November 2020

This study describes the alcohol environment comparing residents’ perceptions and objective measures in two different income-level districts. Measures were gathered between 2017 and 2018 in two districts with different income levels in Madrid, Spain. We obtained perceived measures using Photovoice. We procured objective measures through social systematic observation. Data were integrated using triangulation. Perceived and objective measures of the alcohol environment were characterized and compared in terms of alcohol availability, alcohol promotion, and signs of alcohol consumption. The integration was classified as agreement, partial agreement, or dissonance. The results related to alcohol availability and signs of its consumption showed high agreement. Availability was high in both areas, which was recognized by residents. Residents of the high-income district (HID) discussed fewer signs of alcohol consumption, whilst those in the low-income district (LID) reported extensive signs of consumption. Such observations agreed with the objective measures. There were dissonances between the approaches for alcohol promotion. Although the alcohol promotion was higher in HID according to the objective measures, it was deeply discussed by LID residents. Both methodologies helped us deepen the understanding of the alcohol environment. These results may help design more effective interventions to prevent hazardous drinking.
COVID-19 Pandemic: Epidemiology, Etiology, Conventional and Non-Conventional Therapies
Authors: Rauf Abdur , Abu-Izneid Tareq , Olatunde Ahmed , Ahmed Khalil Anees , Alhumaydhi Fahad A. , Tufail Tabussam , Shariati Mohammad Ali , Rebezov Maksim , Almarhoon Zainab M. , Mabkhot Yahia N. , Alsayari Abdulrhman , Rengasamy Kannan R. R.
Published: November 2020

Coronavirus disease 2019 (COVID-19), which reported in an outbreak in 2019 in Wuhan, Hubei province, China, is caused by the SARS-CoV-2 virus. The virus belongs to the beta-coronavirus class, along with the Middle East Respiratory Syndrome coronavirus and Severe Acute Respiratory Syndrome coronavirus. Interestingly, the virus binds with angiotensin-converting enzyme-2 found in host cells, through the spike (S) protein that exists on its surface. This binding causes the entry of the virus into cells of the host organism. The actual mechanism used by the COVID-19 virus to induce disease is still speculative. A total of 44,322,504 cases, a 1,173,189 death toll and 32,486,703 recovery cases have been reported in 217 countries globally as of 28 October 2020. Symptoms from the infection of the virus include chest pain, fever, fatigue, nausea, and others. Acute respiratory stress syndrome, arrhythmia, and shock are some of the chronic manifestations recorded in severe COVID-19. Transmission is majorly by individual-to-individual through coughing, sneezing, etc. The lack of knowledge regarding the mechanism of and immune response to the virus has posed a challenge in the development of a novel drug and vaccine. Currently, treatment of the disease involves the use of anti-viral medications such as lopinavir, remdesivir, and other drugs. These drugs show some efficacy in the management of COVID-19. Studies are still on-going for the development of an ideal and novel drug for treatment. In terms of natural product intervention, Traditional Chinese Medicines (TCM) have been employed to alleviate the clinical manifestation and severity of the disease and have shown some efficacy. This review presents an updated detailed overview of COVID-19 and the virus, concerning its structure, epidemiology, symptoms and transmission, immune responses, and current interventions, and highlights the potential of TCM. It is anticipated that this review will further add to the understanding of COVID-19 and the virus, hence opening new research perspectives.
Tumour-Infiltrating Inflammatory Cells in Early Breast Cancer: An Underrated Prognostic and Predictive Factor?
Authors: Schnellhardt Sören , Erber Ramona , Büttner-Herold Maike , Rosahl Marie-Charlotte , Ott Oliver J. , Strnad Vratislav , Beckmann Matthias W. , King Lillian , Hartmann Arndt , Fietkau Rainer , Distel Luitpold
Published: November 2020

The role of tumour-infiltrating inflammatory cells (TIICs) in the disease progression of hormone-receptor-positive breast cancer (HR+ BC) is largely unclear since it is generally regarded as the least immunogenic BC subtype. This study investigated the prognostic significance of CD1a+ dendritic cells, CD20+ B cells, CD45RO+ memory T cells and CD4+ T-helper cells in HR+ BC. One hundred and forty-six patients were treated for early stage, distant-metastases-free HR+ BC in an accelerated partial breast irradiation (APBI) phase II trial. Immunohistochemistry was used to double-stain two adjoining sets of tissue microarrays from pre-RT (radiotherapy) tumour resection samples for CD1a/CD20 and CD45RO/CD4. Cell densities of CD1a+, CD20+, CD45RO+ and CD4+ TIICs in the stromal and intraepithelial compartment were registered semiautomatically. High densities of CD20+ and CD4+ TIICs were strongly associated with reduced disease-free survival (DFS), while high stromal CD45RO+ TIIC densities were indicators of subsequent successful treatment. An immunoscore based on CD20+ and CD45RO+ TIIC densities identified three different risk groups (p < 0.001). Thus, contrary to current assumptions, intratumoural immune cell composition might be an important prognostic indicator and a possible contributing factor in the outcome of HR+ BC and should be the subject of further research. Specifically, B-cell infiltration entailed an increased relapse rate and could play an important role in disease progression.
Peritubular Capillary Rarefaction: An Underappreciated Regulator of CKD Progression
Authors: Kida Yujiro
Published: November 2020

Peritubular capillary (PTC) rarefaction is commonly detected in chronic kidney disease (CKD) such as hypertensive nephrosclerosis and diabetic nephropathy. Moreover, PTC rarefaction prominently correlates with impaired kidney function and predicts the future development of end-stage renal disease in patients with CKD. However, it is still underappreciated that PTC rarefaction is a pivotal regulator of CKD progression, primarily because the molecular mechanisms of PTC rarefaction have not been well-elucidated. In addition to the established mechanisms (reduced proangiogenic factors and increased anti-angiogenic factors), recent studies discovered significant contribution of the following elements to PTC loss: (1) prompt susceptibility of PTC to injury, (2) impaired proliferation of PTC, (3) apoptosis/senescence of PTC, and (4) pericyte detachment from PTC. Mainly based on the recent and novel findings in basic research and clinical study, this review describes the roles of the above-mentioned elements in PTC loss and focuses on the major factors regulating PTC angiogenesis, the assessment of PTC rarefaction and its surrogate markers, and an overview of the possible therapeutic agents to mitigate PTC rarefaction during CKD progression. PTC rarefaction is not only a prominent histological characteristic of CKD but also a central driving force of CKD progression.
Effects of Transient Receptor Potential Cation 5 (TRPC5) Inhibitor, NU6027, on Hippocampal Neuronal Death after Traumatic Brain Injury
Authors: Park Min Kyu , Choi Bo Young , Kho A Ra , Lee Song Hee , Hong Dae Ki , Jeong Jeong Hyun , Kang Dong Hyeon , Kang Beom Seok , Suh Sang Won
Published: November 2020

Traumatic brain injury (TBI) can cause physical, cognitive, social, and behavioral changes that can lead to permanent disability or death. After primary brain injury, translocated free zinc can accumulate in neurons and lead to secondary events such as oxidative stress, inflammation, edema, swelling, and cognitive impairment. Under pathological conditions, such as ischemia and TBI, excessive zinc release, and accumulation occurs in neurons. Based on previous research, it hypothesized that calcium as well as zinc would be influx into the TRPC5 channel. Therefore, we hypothesized that the suppression of TRPC5 would prevent neuronal cell death by reducing the influx of zinc and calcium. To test our hypothesis, we used a TBI animal model. After the TBI, we immediately injected NU6027 (1 mg/kg, intraperitoneal), TRPC5 inhibitor, and then sacrificed animals 24 h later. We conducted Fluoro-Jade B (FJB) staining to confirm the presence of degenerating neurons in the hippocampal cornus ammonis 3 (CA3). After the TBI, the degenerating neuronal cell count was decreased in the NU6027-treated group compared with the vehicle-treated group. Our findings suggest that the suppression of TRPC5 can open a new therapeutic window for a reduction of the neuronal death that may occur after TBI.
Galectin-3 Modulates Macrophage Activation and Contributes Smooth Muscle Cells Apoptosis in Abdominal Aortic Aneurysm Pathogenesis
Authors: Lu Hsin-Ying , Shih Chun-Ming , Huang Chun-Yang , Wu Alexander T. H. , Cheng Tsai-Mu , Mi Fwu-Long , Shih Chun-Che
Published: November 2020

Galectin-3 (Gal-3) is a 26-kDa lectin that regulates many aspects of inflammatory cell behavior. We assessed the hypothesis that increased levels of Gal-3 contribute to abdominal aortic aneurysm (AAA) progression by enhancing monocyte chemoattraction through macrophage activation. We analyzed the plasma levels of Gal-3 in 76 patients with AAA (AAA group) and 97 controls (CTL group) as well as in angiotensin II (Ang-II)-infused ApoE knockout mice. Additionally, conditioned media (CM) were used to polarize THP-1 monocyte to M1 macrophages with or without Gal-3 inhibition through small interfering RNA targeted deletion to investigate whether Gal-3 inhibition could attenuate macrophage-induced inflammation and smooth muscle cell (SMC) apoptosis. Our results showed a markedly increased expression of Gal-3 in the plasma and aorta in the AAA patients and experimental mice compared with the CTL group. An in vitro study demonstrated that the M1 cells exhibited increased Gal-3 expression. Gal-3 inhibition markedly decreased the quantity of macrophage-induced inflammatory regulators, including IL-8, TNF-α, and IL-1β, as well as messenger RNA expression and MMP-9 activity. Moreover, Gal-3-deficient CM weakened SMC apoptosis through Fas activation. These findings prove that Gal-3 may contribute to AAA progression by the activation of inflammatory macrophages, thereby promoting SMC apoptosis.
Genome-Wide Identification and Functional Characterization of the Cation Proton Antiporter (CPA) Family Related to Salt Stress Response in Radish (Raphanus sativus L.)
Authors: Wang Yan , Ying Jiali , Zhang Yang , Xu Liang , Zhang Wanting , Ni Meng , Zhu Yuelin , Liu Liwang
Published: November 2020

The CPA (cation proton antiporter) family plays an essential role during plant stress tolerance by regulating ionic and pH homeostasis of the cell. Radish fleshy roots are susceptible to abiotic stress during growth and development, especially salt stress. To date, CPA family genes have not yet been identified in radish and the biological functions remain unclear. In this study, 60 CPA candidate genes in radish were identified on the whole genome level, which were divided into three subfamilies including the Na+/H+ exchanger (NHX), K+ efflux antiporter (KEA), and cation/H+ exchanger (CHX) families. In total, 58 of the 60 RsCPA genes were localized to the nine chromosomes. RNA-seq. data showed that 60 RsCPA genes had various expression levels in the leaves, roots, cortex, cambium, and xylem at different development stages, as well as under different abiotic stresses. RT–qPCR analysis indicated that all nine RsNHXs genes showed up regulated trends after 250 mM NaCl exposure at 3, 6, 12, and 24h. The RsCPA31 (RsNHX1) gene, which might be the most important members of the RsNHX subfamily, exhibited obvious increased expression levels during 24h salt stress treatment. Heterologous over-and inhibited-expression of RsNHX1 in Arabidopsis showed that RsNHX1 had a positive function in salt tolerance. Furthermore, a turnip yellow mosaic virus (TYMV)-induced gene silence (VIGS) system was firstly used to functionally characterize the candidate gene in radish, which showed that plant with the silence of endogenous RsNHX1 was more susceptible to the salt stress. According to our results we provide insights into the complexity of the RsCPA gene family and a valuable resource to explore the potential functions of RsCPA genes in radish.
The Cervicovaginal Mucus Barrier
Authors: Lacroix Guillaume , Gouyer Valérie , Gottrand Frédéric , Desseyn Jean-Luc
Published: November 2020

Preterm births are a global health priority that affects 15 million babies every year worldwide. There are no effective prognostic and therapeutic strategies relating to preterm delivery, but uterine infections appear to be a major cause. The vaginal epithelium is covered by the cervicovaginal mucus, which is essential to health because of its direct involvement in reproduction and functions as a selective barrier by sheltering the beneficial lactobacilli while helping to clear pathogens. During pregnancy, the cervical canal is sealed with a cervical mucus plug that prevents the vaginal flora from ascending toward the uterine compartment, which protects the fetus from pathogens. Abnormalities of the cervical mucus plug and bacterial vaginosis are associated with a higher risk of preterm delivery. This review addresses the current understanding of the cervicovaginal mucus and the cervical mucus plug and their interactions with the microbial communities in both the physiological state and bacterial vaginosis, with a focus on gel-forming mucins. We also review the current state of knowledge of gel-forming mucins contained in mouse cervicovaginal mucus and the mouse models used to study bacterial vaginosis.
Microbiological, Physicochemical, and Immunological Analysis of a Commercial Cashew Nut-Based Yogurt
Authors: Mattison Christopher P. , Aryana Kayanush J. , Clermont Kristen , Prestenburg Eric , Lloyd Steven W. , Grimm Casey C. , Wasserman Richard L.
Published: November 2020

Nut-based milks and yogurts are gaining popularity, but may not offer the same benefits as dairy yogurts to consumers. Cashew nuts often cause severe allergic reactions, and cashew nut allergens are stable to several types of processing. To compare its characteristics to dairy yogurt and characterize the effects of fermentation on the Ana o 1–3 cashew nut allergens, a commercial yogurt made from cashew nuts (Cashewgurt) was evaluated for microbiological, physiochemical, and immunological properties. Average counts for lactobacilli and Streptococcus thermophilus were greater than 10 million colony forming units per milliliter, indicating the capacity to provide a health benefit. Cashewgurt pH and viscosity values were comparable to cow milk yogurts, and it was off white in color. SDS-PAGE analysis indicated a clear reduction in Ana o 1 and 2, and immuno-assay with polyclonal anti-cashew IgG antibody and cashew-allergic IgE indicated an overall reduction in allergen content. In contrast, SDS-PAGE, mass spectrometry, immunoblot, and ELISA all revealed that Ana o 3 was relatively unaffected by the fermentation process. In conclusion, Ana o 1 and Ana o 2 are sensitive to degradation, while Ana o 3 survives lactic acid bacterial fermentation during yogurt production. The analysis presented here indicates that cashew nut yogurt is not suitable for those with cashew nut allergy.
Social Capital on Social Media—Concepts, Measurement Techniques and Trends in Operationalization
Authors: Poecze Flora , Strauss Christine
Published: November 2020

The introduction of the Web 2.0 era and the associated emergence of social media platforms opened an interdisciplinary research domain, wherein a growing number of studies are focusing on the interrelationship of social media usage and perceived individual social capital. The primary aim of the present study is to introduce the existing measurement techniques of social capital in this domain, explore trends, and offer promising directions and implications for future research. Applying the method of a scoping review, a set of 80 systematically identified scientific publications were analyzed, categorized, grouped and discussed. Focus was placed on the employed viewpoints and measurement techniques necessary to tap into the possible consistencies and/or heterogeneity in this domain in terms of operationalization. The results reveal that multiple views and measurement techniques are present in this research area, which might raise a challenge in future synthesis approaches, especially in the case of future meta-analytical contributions.
Anti-Termitic Activity of Three Plant Extracts, Chlorpyrifos, and a Bioagent Compound (Protecto) against Termite Microcerotermes eugnathus Silvestri (Blattodea: Termitidae) in Egypt
Authors: Salem Mohamed Z. M. , Ali Mona F. , Mansour Maisa M. A. , Ali Hayssam M. , Abdel Moneim Esraa M. , Abdel-Megeed Ahmed
Published: November 2020

A trend towards environmentally friendly chemicals for use in termite management has been occurring globally. This study examined three naturally occurring plant extracts from Lavandula latifolia (Spike lavender), Origanum vulgare (Marjorum), and Syzygium aromaticum (Clove) against the termite Microcerotermes eugnathus. Plant extract results were compared to two commercially used termite pesticides, the bio-insecticide, Bacillus thuringiensis var. kurstaki (Protecto 9.4% WP) and Dursban (Chlorpyrifos 48%). Gas chromatography–mass spectrometry (GC-MS) analysis was used to identify the main compounds in the three plant extracts. The main compounds in Lavandula Latifolia were linalool (21.49%), lavandulol (12.77%), β-terpinyl acetate (10.49%), and camphor (9.30%). Origanum vulgare extract contained thymol (14.64%), m-cymene (10.63%), linalool (6.75%), and terpinen-4-ol (6.92%) as main compounds. Syzygium aromaticum contained eugenol (99.16%) as the most abundant identified compound. The extract of O. vulgare caused the highest termite death rate, with an LC50 of 770.67 mg/L. Exposure to lavender extract showed a high death rate with an LC50 of 1086.39 mg/L. Clove extract did not show significant insecticidal activity with an LC50 > 2000 mg/L. Significant termiticide effects were found, with LC50 values of 84.09 and 269.98 mg/L for soldiers and workers under the application of Dursban and Protecto, respectively. The LC50 values reported for nymphs were <120, <164.5, and 627.87 mg/L after exposure to Dursban, Protecto, and O. vulgare extract, respectively. The results of the study show that some of the extracts have low toxicity compared to the bioagent and Dursban, and may show promise as natural termiticides, particularly as extracts from O. vulgare.
A Proposed Low-Cost Viticulture Stress Framework for Table Grape Varieties
Authors: Kontogiannis Sotirios , Asiminidis Christodoulos
Published: November 2020

Climate change significantly affects viticulture by reducing the production yield and the quality characteristics of its final products. In some observed cases, the consequences of climate outages such as droughts, hail and floods are absolutely devastating for the farmers and the sustained local economies. Hence, it is essential to develop new in implementation monitoring solutions that offer remote real-time surveillance, alert triggering, minimum maintenance and automated generation of incident alerts with precision responses. This paper presents a new framework and a system for vine stress monitoring called Vity-stress. The Vity-stress framework combines field measurements with precise viticulture suggestions and stress avoidance planning. The key points of the proposed framework’s system are that it is easy to develop, easy to maintain and cheap to implement applicability. Focusing on the Mediterranean cultivated table grape varieties that are strongly affected by climate change, we propose a new stress conditions monitoring system to support our framework. The proposition includes distributed field located sensors and a novel camera module implementing deep neural network algorithms to detect stress indicators. Additionally, a new wireless sensor network supported by the iBeacon protocol has been developed. The results of the sensory measurements’ data logging and imposed image detection process’s evaluation shows that the proposed system can successfully detect different stress levels in vineyards, which in turn can allow producers to identify specific areas for irrigation, thereby saving water, energy and time.
New Target Therapies in Advanced Non-Small Cell Lung Cancer: A Review of the Literature and Future Perspectives
Authors: de Mello Ramon Andrade , Neves Nathália Moisés , Tadokoro Hakaru , Amaral Giovanna Araújo , Castelo-Branco Pedro , Zia Victor André de Almeida
Published: November 2020

Introduction: Lung cancer (LC) is the most common neoplasm worldwide, and 85% of these tumors are classified as non-small cell lung cancer (NSCLC). LC treatment was initially restricted to cytotoxic chemotherapy—platinum compounds associated with 3rd generation cytotoxic agents (paclitaxel, gemcitabine, pemetrexed) and, more recently, with monoclonal antibodies (bevacizumab, ramucirumab). Advancements in treatment are correlated with prolonged overall survival (OS). Current advances are focused on target therapies. Target agents: Anti-epidermal growth factor receptor (EGFR) therapy consists of 1st and 2nd generation tyrosine kinase inhibitors (TKIs such as erlotinib, afatinib). In 60% of cases, resistance to these TKIs occurs due to T790M mutation in EGFR, which is overcome 3rd generation drugs (osimertinib). Anaplastic lymphoma kinase (ALK) is the target for drugs such as crizotinib, alectinib, ceritinib. Programmed death 1 (PD-1) and its ligand serve as targets for immunotherapy agents such as pembrolizumab, nivolumab, atezolizumab. Discussion: Challenges in NSCLC treatment include resistance to 3rd generation TKIs, the high cost of ALK inhibitors, and the need for further research on new drugs.
Persistent Ependymal Tumor Arising from an Immature Ovarian Teratoma: A Rare Case
Authors: Afzal Anoshia , Lu Rufei , Asadbeigi Sepideh N. , Fung Kar-Ming , Peterson Jo Elle G.
Published: November 2020

Primary ovarian ependymoma is a rare neuroectodermal neoplasm that can arise from immature ovarian teratoma. Due to the paucity of this entity, a complete molecular analysis of these tumors has not been done, thus creating a challenge for finding an effective and safe therapeutic treatment. In the limited literature, patients with primary ovarian ependymoma showed various responses to an array of individualized therapies, ranging from surgeries to chemotherapies. Here, we present a 38-year-old female with persistent ovarian ependymoma, with a molecular profile similar to traditional central nervous system ependymoma that is irresponsive to multiple cytoreduction and clinical experimental therapies. Therefore, a prompt recognition and reporting of this entity can greatly aid in expanding the understanding and standardization of therapies for this neoplasm.
Soluble Immune Checkpoints, Gut Metabolites and Performance Status as Parameters of Response to Nivolumab Treatment in NSCLC Patients
Authors: Zizzari Ilaria , Di Filippo Alessandra , Scirocchi Fabio , Di Pietro Francesca , Rahimi Hassan , Ugolini Alessio , Scagnoli Simone , Vernocchi Pamela , Del Chierico Federica , Putignani Lorenza , Rughetti Aurelia , Marchetti Paolo , Nuti Marianna , Botticelli Andrea , Napoletano Chiara
Published: November 2020

Patients with non-small cell lung cancer (NSCLC) have been shown to benefit from the introduction of anti-PD1 treatment. However, not all patients experience tumor regression and durable response. The identification of a string of markers that are direct or indirect indicators of the immune system fitness is needed to choose optimal therapeutic schedules in the management of NSCLC patients. We analyzed 34 immuno-related molecules (14 soluble immune checkpoints, 17 cytokines/chemokines, 3 adhesion molecules) released in the serum of 22 NSCLC patients under Nivolumab treatment and the gut metabolomic profile at baseline. These parameters were correlated with performance status (PS) and/or response to treatment. Nivolumab affected the release of soluble immune checkpoints (sICs). Patients with a better clinical outcome and with an optimal PS (PS = 0) showed a decreased level of PD1 and maintained low levels of several sICs at first clinical evaluation. Low levels of PDL1, PDL2, Tim3, CD137 and BTLA4 were also correlated with a long response to treatment. Moreover, responding patients showed a high proportion of eubiosis-associated gut metabolites. In this exploratory study, we propose a combination of immunological and clinical parameters (sICs, PS and gut metabolites) for the identification of patients more suitable for Nivolumab treatment. This string of parameters validated in a network analysis on a larger cohort of patients could help oncologists to improve their decision-making in an NSCLC setting.
Climatic Impact Toward Regional Water Allocation and Transfer Strategies from Economic, Social and Environmental Perspectives
Authors: Xu Zhongwen , Yao Liming , Long Yin
Published: November 2020

Aiming to store water in wet seasons and outflow water in dry seasons, and improve reservoirs’ performance, are of great importance. Given the developmental disparities across regions and uneven precipitation within one year, water transfer could be an efficient solution. Here, we formulated a three-stage decision-making framework to simulate possible hydrological, meteorological, economic, and demographic parameters in future scenarios and proposed a market-based dynamic multi-objective optimization model, which optimized the adjusted water allocation and water transfers strategies among regions. A case study was conducted in the Yiluo river basin to evaluate the optimal proportion of local water use and water transfers to verify the application and its effects. Results indicated that water use stress and environmental stress could be relieved from four simulated future scenarios, which further accelerated region- and basin-scale sustainability. The results also gave valuable insights into optimal water use options and transferred to maximize the economic, social, and environmental benefits and climate mitigation.
Assessment of Changes in a Viewshed in the Western Carpathians Landscape as a Result of Reforestation
Authors: Sobala Michał , Myga-Piątek Urszula , Szypuła Bartłomiej
Published: November 2020

A viewshed analysis is of great importance in mountainous areas characterized by high landscape values. The aim of this research was to determine the impact of reforestation occurring on former pasturelands on changes in the viewshed, and to quantify changes in the surface of glades. We combine a horizontal and a vertical approach to landscape analysis. The changes in non-forest areas and the viewshed from viewpoints located in glades were calculated using historical cartographic materials and a more recent Digital Elevation Model and Digital Surface Model. An analysis was conducted using a Visibility tool in ArcGIS. The non-forest areas decreased in the period 1848–2015. The viewshed in the majority of viewpoints also decreased in the period 1848–2015. In the majority of cases, the maximal viewsheds were calculated in 1879/1885 and 1933 (43.8% of the analyzed cases), whereas the minimal ones were calculated in 2015 (almost 57.5% of analyzed cases). Changes in the viewshed range from 0.2 to 23.5 km2 with half the cases analyzed being no more than 1.4 km2. The results indicate that forest succession on abandoned glades does not always cause a decline in the viewshed. Deforestation in neighboring areas may be another factor that has an influence on the decline.
Biocompatible Nanocomposite Enhanced Osteogenic and Cementogenic Differentiation of Periodontal Ligament Stem Cells In Vitro for Periodontal Regeneration
Authors: Liu Jin , Dai Quan , Weir Michael D. , Schneider Abraham , Zhang Charles , Hack Gary D. , Oates Thomas W. , Zhang Ke , Li Ang , Xu Hockin H. K.
Published: November 2020

Decays in the roots of teeth is prevalent in seniors as people live longer and retain more of their teeth to an old age, especially in patients with periodontal disease and gingival recession. The objectives of this study were to develop a biocompatible nanocomposite with nano-sized calcium fluoride particles (Nano-CaF2), and to investigate for the first time the effects on osteogenic and cementogenic induction of periodontal ligament stem cells (hPDLSCs) from human donors.Nano-CaF2 particles with a mean particle size of 53 nm were produced via a spray-drying machine.Nano-CaF2 was mingled into the composite at 0%, 10%, 15% and 20% by mass. Flexural strength (160 ± 10) MPa, elastic modulus (11.0 ± 0.5) GPa, and hardness (0.58 ± 0.03) GPa for Nano-CaF2 composite exceeded those of a commercial dental composite (p < 0.05). Calcium (Ca) and fluoride (F) ions were released steadily from the composite. Osteogenic genes were elevated for hPDLSCs growing on 20% Nano-CaF2. Alkaline phosphatase (ALP) peaked at 14 days. Collagen type 1 (COL1), runt-related transcription factor 2 (RUNX2) and osteopontin (OPN) peaked at 21 days. Cementogenic genes were also enhanced on 20% Nano-CaF2 composite, promoting cementum adherence protein (CAP), cementum protein 1 (CEMP1) and bone sialoprotein (BSP) expressions (p < 0.05). At 7, 14 and 21 days, the ALP activity of hPDLSCs on 20% Nano-CaF2 composite was 57-fold, 78-fold, and 55-fold greater than those of control, respectively (p < 0.05). Bone mineral secretion by hPDLSCs on 20% Nano-CaF2 composite was 2-fold that of control (p < 0.05). In conclusion, the novel Nano-CaF2 composite was biocompatible and supported hPDLSCs. Nano-CaF2 composite is promising to fill tooth root cavities and release Ca and F ions to enhance osteogenic and cementogenic induction of hPDLSCs and promote periodontium regeneration.
The Sticking Out Mechanism and Growth of TiB Whiskers from TiBw/Ti-6Al-4V Composites during Sintering
Authors: Cui Guorong , Yang Bo , Hou Jiabin , Chen Wenzhen , Zhang Wencong
Published: November 2020

The process of TiB whiskers (TiBw) squeezed out and the growth of sticking out TiBw were investigated in TiBw/Ti-6Al-4V composites via adding 5 vol% TiB2 powders. TiB2 distributed along the surface of Ti-6Al-4V powders by low energy milling, resulted in the enrichment region of B and Ti elements. During sintering, TiBw nucleated and grew along the [010] direction with the diffusion of B and Ti atoms in the enrichment region. Due to larger thermal expansion ratio of TiBw, the TiBw were squeezed out from the Ti matrix, and the sticking out TiBw grew gradually with the diffusion of B and Ti atoms from the enrichment region. Because of the high interfacial strength between TiBw and Ti matrix, the matrix adhered to TiBw, and hindered the squeezing out of TiBw. Eventually, the cone TiBw stuck out the Ti matrix, and the other end of TiBw pinned in Ti matrix. Moreover, the diameter of TiBw near surface between TiB2 and Ti matrix was larger than other areas, resulting from the high concentration of B and Ti atoms. The solubilized B atoms near TiBw were absorbed by TiBw, which was considered as the other B source of TiBw.
OXYFINES Technique for Upgrading Zinc Containing Blast Furnace Sludge—Part 1: Pilot Trials
Authors: Lundkvist Katarina , Rosendahl Sara , Nyman Fredrik , Bölke Kristofer , Gustavsson Lennart , Söderström Daniel , Wedholm Anita
Published: November 2020

In the Swedish steel industry, much work is put on further increasing the recycling and use of residual materials. However, blast furnace sludge is one residual which currently, despite its valuable contents of iron and carbon, is put on landfill or long-term storage due to its zinc content. Linde has developed the OXYFINES technique which is suitable for upgrading of fine particulate and zinc containing materials. The material is fed to the OXYFINES burner whereby its zinc content is vaporised to a generated dust phase whereas other non-gasifiable contents, such as iron, forms an oxidic sinter phase in the bottom of the reactor. The technique has proven a high degree of zinc separation, is relatively flexible and straightforward, and does not require sludge pre-treatment such as drying. Pilot set-up and trials, using the OXYFINES technique, were performed at Swerim’s research facility. In the trials, the effects from altering different process parameters were tested aiming to develop an optimal concept for upgrading the blast furnace sludge. The pilot trials’ results showed the required process settings to attain a high degree of zinc separation from the sludge, and to generate an iron oxide product, suitable for straightforward charging to the steelmaking process.
Vacuum Brazing of 55 vol.% SiCp/ZL102 Composites Using Micro-Nano Brazing Filler Metal Fabricated by Melt-Spinning
Authors: Qiu Dechao , Gao Zeng , Ba Xianli , Wang Zhenjiang , Niu Jitai
Published: November 2020

The joining methods of Aluminum matrix composites reinforced with SiC particles (SiCp/Al MMCs) are a challenge during the manufacturing process due to the significant differences between SiC particles and base aluminum in terms of both physical and chemical properties. Micro-nano brazing filler metal Al-17.0Cu-8.0Mg fabricated by melt-spinning technology was employed to deal with the joining problem of 55 vol.% SiCp/ZL102 composites in this work. The result indicated that the foil-like brazing filler metal contained uniformed cellular nano grains, with a size less than 200 nm. The solidus and liquidus temperatures of the foil-like brazing filler metal decreased by 4 °C and 7 °C in comparison with the values of the as-cast brazing filler metal due to the nanometer size effect. The maximum joint shear strength of 98.17 MPa achieved with a brazing temperature of 580 °C and holding time of 30 min was applied in vacuum brazing process. The width of the brazing seam became narrower and narrower with increasing brazing temperature owning to the strong interaction between the micro-nano brazing filler metal and 55 vol.% SiCp/ZL102 composites. The fracture morphology of the joint made at a brazing temperature of 580 °C was characterized by quasi-cleavage fracture. After brazing, the chemical concentration gradient between the brazing filler metal and base material disappeared.
OXYFINES Technique for Upgrading Zinc Containing Blast Furnace Sludge—Part 2: System Analysis
Authors: Lundkvist Katarina , Rosendahl Sara , Nyman Fredrik , Bölke Kristofer , Gustavsson Lennart , Söderström Daniel , Wedholm Anita
Published: November 2020

Integrating novel technology in production systems for the upgrading and further use of residual materials is a potential way of improving the resource efficiency. Assessing technology integration prospects, by performing system analysis, assists in the forecasting of effects and opportunities for different concepts. Based on pilot trials results, using Linde’s OXYFINES technique for upgrading zinc containing blast furnace sludge, a system analysis was performed on the prospects of integrating an OXYFINES concept in an iron and steel production route. The calculations were made based on one option for a full-scale OXYFINES concept for indicating the effects on the blast furnace zinc load, raw material consumption, energy use and carbon dioxide emissions from using the OXYFINES sinter product as a raw material in blast furnace ironmaking or in the basic oxygen furnace steelmaking. The summarised system analysis results showed that the most advantageous metallurgical, environmental, and economic potential was realised in the calculations of using the sinter in the basic oxygen furnace. However, the sinter was found as well suitable for use in the blast furnace when considering mainly the metallurgical and the economic effects.
Recent Advances in the Laser Forming Process: A Review
Authors: Safari Mehdi , Alves de Sousa Ricardo , Joudaki Jalal
Published: November 2020

Laser forming is an emerging manufacturing process capable of producing either uncomplicated and complicated shapes by employing a concentrated heating source. The heat source movement creates local softening, and a plastic strain will be induced during the rise of temperature and the subsequent cooling. This contactless forming process may be used for the simple bending of sheets and tubes or fabrication of doubly-curved parts. Different studies have been carried out over recent years to understand the mechanism of forming and predicting the bending angle. The analysis of process parameters and search for optimized manufacturing conditions are among the most discussed topics. This review describes the main recent findings in the laser forming of single and multilayer sheets, composite and fiber-metal laminate plates, force assisted laser bending, tube bending by laser beam, the optimization technique implemented for process parameters selection and control, doubly-curved parts, and the analytical solutions in laser bending. The main focus is set to the researches published since 2015.