bluuebunny/crossref_metadata_2025 huggingface dataset:
Demographic Differences in Compliance with COVID-19 Vaccination Timing and Completion Guidelines in the United States
Authors: Zhu Peiyao , Zhang Victoria , Wagner Abram L.
Published: February 2023

Background: The development of vaccines has been a significant factor in eliminating the pandemic caused by the novel coronavirus (SARS-CoV-2). However, the primary series vaccination rate still falls short of our expectations, with an even lower rate of uptake for booster shots. This study examined demographic patterns of COVID-19 vaccination compliance by assessing patterns in the timing of the vaccine series start and vaccination completion and characterizing people by compliance with vaccination recommendations. Methods: A cross-sectional survey was conducted online in August 2022. Participants answered questions about the COVID-19 vaccine and questions related to their personal backgrounds. We assessed the impact of demographic factors on COVID-19 vaccination using multivariable regression modeling. Results: Among 700 eligible participants, 61% (389) were highly adherent (i.e., started by late 2020 and received a booster dose), 22% (184) were moderately adherent (i.e., started later than June 2021, and/or did not receive the booster dose), and 17% (127) were unvaccinated. Compliance was relatively low among non-Hispanic Black Americans, those with no religious affiliation, and among Independents and Republicans. Conclusion: Vaccination compliance varies across demographic groups. Race/ethnicity, religion, and political affiliation are highly associated with vaccination compliance. To promote vaccination compliance and decrease vaccine hesitancy, the government and healthcare institutions should establish a positive image to obtain public trust and adopt effective vaccine education and intervention.
COVID-19 Vaccination in Romania and the Benefits of the National Electronic Registry of Vaccinations
Authors: Enciu Bianca Georgiana , Pițigoi Daniela , Zaharia Alina , Popescu Rodica , Niculcea Andreea , Crăciun Maria-Dorina , Pistol Adriana
Published: February 2023

Background: Recording real-time data of vaccinations performed, vaccine stocks, and adverse events following immunization is a particularly useful activity in the effective development of any vaccination campaign or vaccination program, guiding the decisions of public health authorities. The aim of this paper is to present the benefits of the National Electronic Registry of Vaccinations in providing useful information for the optimization of healthcare vaccination policies, specifically related to COVID-19 vaccination. Methods: We performed a descriptive study using data available in the reports generated from the National Electronic Registry of Vaccinations regarding COVID-19 vaccinations performed between 27 December 2020 and 31 December 2021. Results: A total of 27,980,270 doses of the COVID-19 vaccine were distributed. Of these, 15,757,638 (56%) were administered in 4545 vaccination centers: 7,882,458 as the 1st dose (50%), 5,878,698 as the 2nd dose (37%), and 1,996,482 as the 3rd dose (13%). More than 25% of the total doses were administered to people over 65 years of age. A total of 41% of the population received at least one dose of the COVID-19 vaccine. A total of 4083 adverse events following immunization were reported. Conclusions: The existence of a National Electronic Registry of Vaccinations containing accurate information on vaccinations performed in Romania offers the opportunity to obtain a clear picture of vaccination status that will significantly contribute to the optimization of vaccination strategies and programs.
A Competitive Panning Method Reveals an Anti-SARS-CoV-2 Nanobody Specific for an RBD-ACE2 Binding Site
Authors: He Siqi , Wang Jiali , Chen Hanyi , Qian Zhaohui , Hu Keping , Shi Bingjie , Wang Jianxun
Published: February 2023

Most neutralizing antibodies neutralize the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by directly blocking the interactions between the spike glycoprotein receptor-binding domain (RBD) and its receptor, human angiotensin-converting enzyme 2 (ACE2). Here, we report a novel nanobody (Nb) identified by an RBD-ACE2 competitive panning method that could specifically bind to the RBD of SARS-CoV-2 with a high affinity (EC50 = 0.03 nM) and successfully block the binding between the RBD and ACE2 recombinant protein. A structural simulation of the RBD-VHH complex also supports a mechanism of the Nb to block the interaction between the RBD and ACE2. A pseudovirus assay of the Nb showed it could neutralize the WT pseudovirus with high potency (IC50 = 0.026 μg/mL). Furthermore, we measured its binding to phages displaying RBDs of different SARS-CoV-2 variants and found that it could bind to recombinant phages displaying the RBD of beta and delta variants. This study also provides a method of phage library competitive panning, which could be useful for directly screening high-affinity antibodies targeting important functional regions.
Detection of Porcine Deltacoronavirus RNA in the Upper and Lower Respiratory Tract and Biliary Fluid and the Effect of Infection on Serum Cholesterol Levels and Blood T Cell Population Frequencies in Gnotobiotic Piglets
Authors: Bedsted Amalie Ehlers , Jung Kwonil , Saif Linda J.
Published: February 2023

Porcine deltacoronavirus (PDCoV) was first identified approximately a decade ago, but much is still obscure in terms of its pathogenesis. We aimed to further characterize PDCoV infection by investigating the presence of virus in respiratory and biliary tissues or fluids; T cell population frequencies in blood; and altered serum cholesterol levels. Twelve, 6-day-old, gnotobiotic piglets were inoculated oronasally with PDCoV OH-FD22 (2.6 × 107 FFU/pig). Six control piglets were not inoculated. Rectal swab (RS), nasal swab (NS), nasal wash (NW), bronchoalveolar lavage (BAL), and biliary fluid (BF) samples were collected at 2, 4, and 7 days post-inoculation (DPI) and tested for PDCoV RNA by RT-qPCR. Blood T cell populations and serum cholesterol levels were determined by flow cytometry and a colorimetric assay, respectively. Moderate to high, and low to moderate titers of PDCoV RNA were detected in RS and in NS, NW, BAL, and BF samples, respectively, of inoculated piglets. There were trends toward decreased CD4+CD8−, CD4−CD8+, and CD4+CD8+ blood T cell frequencies in inoculated piglets. Furthermore, serum cholesterol levels were increased in inoculated piglets. Overall, we found that PDCoV infection does not exclusively involve the intestine, since the respiratory and biliary systems and cholesterol metabolism also can be affected.
Antibacterial, Antifungal, and Anticancer Effects of Camel Milk Exosomes: An In Vitro Study
Authors: Shaban Amira M. , Raslan Mai , Sharawi Zeina Walid , Abdelhameed Mohamed Sayed , Hammouda Ola , El-Masry Hossam M. , Elsayed Khaled N. M. , El-Magd Mohammed A.
Published: February 2023

Camel milk (CM) has potent antibacterial and antifungal effects and camel milk exosomes (CM-EXO) have been shown to inhibit the proliferation of a large variety of cancer cells including HepaRG, MCF7, Hl60, and PANC1. However, little is known regarding the effects of CM-EXO on bacteria, fungi, HepG2, CaCo2, and Vero cells. Therefore, this study aimed to evaluate the antibacterial, antifungal, and anticancer effects of CM-EXO. EXOs were isolated from CM by ultracentrifugation and characterized by transmission electron microscope and flow cytometry. Unlike CM, CM-EXO (6 mg/mL) had no bactericidal effects on Gram-positive bacteria (Staphylococcus aureus, Micrococcus luteus, and Enterococcus feacalis) but they had bacteriostatic effects, especially against Gram-negative strains (Escherichia coli, Pseudomonas aeruginosa, and Proteus mirabilis), and fungistatic effects on Candida albicans. HepG2, CaCo2, and Vero cells were respectively treated with CM-EXOs at low (6.17, 3.60, 75.35 μg/mL), moderate (12.34, 7.20, 150.70 μg/mL), and high (24.68, 14.40, 301.40 μg/mL) doses and the results revealed that CM-EXOs triggered apoptosis in HepG2 and CaCo2 cells, but not in normal Vero cells, as revealed by high Bax expression and caspase 3 activities and lower expression of Bcl2. Interestingly, CM-EXOs also induced the elevation of intracellular reactive oxygen species and downregulated the expression of antioxidant-related genes (NrF2 and HO-1) in cancer cells but not in normal cells. CM-EXOs have antibacterial and antifungal effects as well as a selective anticancer effect against HepG2 and CaCo2 cells with a higher safety margin on normal cells.
Effect of Rotational Speed on Pressure Pulsation Characteristics of Variable-Speed Pump Turbine Unit in Turbine Mode
Authors: Shang Linmin , Cao Jingwei , Jia Xin , Yang Shengrui , Li Sainan , Wang Lei , Wang Zhengwei , Liu Xiaobing
Published: February 2023

The pumped storage power station plays a vital role in modern power systems, where the key component is the pump turbine. Variable-speed operation can improve the operating efficiency of the pump turbine and increase the operating efficiency under turbine operating conditions and the automatic frequency regulation capability under pump operating conditions, thus obtaining higher efficiency and better stability. However, its operation characteristics are different from many conventional pumped storage units, which makes the study of variable-speed pump turbines more difficult. Therefore, in this paper, 10 representative pressure monitoring points are selected in the model to compare and study the flow characteristics and pressure pulsation characteristics of a variable-speed pump turbine at three speeds (N1-398.57 m/s, N2-412.16 m/s, and N3-428.6 m/s). According to our results, it is shown that the maximum pressure and pressure pulsation are small at low rotational speeds, which means that the unit will maintain better stability during the reduction in rotational speed and reducing the speed will not affect the safety and stability of the equipment. The purpose of this paper is to provide guidance for the safe operation of the unit and to improve the effect of speed in terms of dynamic behavior of variable-speed water pump turbine units. Meanwhile, this study will lay the groundwork for the optimal design of variable-speed pump turbines.
Why Don’t Young People Seek Help for Mental Illness? A Cross-Sectional Study in Greece
Authors: Koutra Katerina , Pantelaiou Varvara , Mavroeides Georgios
Published: February 2023

Young adults are less likely to seek professional help even though they are most likely to experience mental health problems. The aim of the present study was to investigate young adults’ attitudes towards mental illness and self-stigma of help-seeking, identify possible determinants of attitudes and self-stigma, and examine the association between attitudes towards mental illness and self-stigma of help-seeking. The sample consisted of 485 Greek young adults (24.5% men, 75.5% women) aged 18–25 years (M = 19.54, SD = 1.83) who completed the Attitudes towards Severe Mental Illness (ASMI) and the Self-Stigma of Seeking Help Scale (SSOSH). The results indicated that Greek young adults hold mostly positive attitudes towards severe mental illness and help-seeking, while their unfavorable attitudes are mainly related to difficulties with viewing people with a severe mental disorder as similar to other people, and fear that by seeking professional help a person’s worth will be diminished. Gender, age, familiarity with mental health difficulties, education, and relationship status were found to be associated with young adults’ attitudes towards severe mental illness and self-stigma of help-seeking. Finally, stereotyping, pessimistic beliefs, and negative beliefs about coping with mental illness were identified as key determinants of self-stigma of help-seeking. These findings suggest a need for age- and gender-sensitive psychoeducational interventions specifically designed to promote young adults’ mental health literacy and to ameliorate unfavorable attitudes towards mental illness in order to increase help-seeking behavior.
POINDUSTRINIS MIESTO KŪRIMAS: KULTŪRINIAI IR SOCIALINIAI DEINDUSTRIALIZACIJOS PROCESAI ALYTAUS, MARIJAMPOLĖS IR PLUNGĖS MIESTUOSE
Authors:   , Teleišė Aušra
Published: February 2023

Aim of the Research: To analyze the cultural and social processes and factors that transformed the Soviet industrial city in the wake of post-Soviet deindustrialization in Lithuania. Objectives: 1. To discuss the anthropological concepts of the city, place and landscape and the post-industrial era, and to define a theoretical approaches that conceptualize the post-industrial city-making, and the methodology of the research. 2. To describe the historical and urban characteristics of Alytus, Marijampolė and Plungė as the context of their contemporary state of being. 3. To investigate the ways in which industrial enterprises, their employees and the city residents experienced the post-Soviet deindustrialization and to reveal the changes in the concept of ’labor’, to examine the establishment of new work activities, their occupational and structural diversity, and the factors that make influence on the formation of the post-industrial urban landscape. 4. To examine the change of attitudes towards industry in the city, the encounter between industry and nature in the wake of the unexpected environmental accident, the emergence of new aspects of the relationship between industry and nature in the post-industrial era, and the green spaces that have been emphasized by the city residents. 5. Assessing the aspect of shrinking of the city under the post-Soviet de-industrialization, to disclose the main characteristics of this social situation and to discuss the opinions and experiences of city residents; and to examine the changing concept of the city. The Object of the Research: Post-Soviet and post-industrial urban processes in Lithuania, and their cultural and social characteristics and factors.
Evaluation of the influence of learning conditions at a military university of the humanitarian type on the physical development of students
Authors:   Federal State Budgetary Educational Institution of Higher Education ", Rakhmanov R.S. ,   Privolzhsky Research Medical University",   of the Ministry of Health of the Russian Federation, Nizhny Novgorod, Russia, Bogomolova E.S. ,   Federal State Budgetary Educational Institution of Higher Education "Privolzhsky Research Medical University" of the Ministry of Health of the Russian Federation, Nizhny Novgorod, Russia, Razgulin S.A. ,   Federal State Budgetary Educational Institution of Higher Education "Privolzhsky Research Medical University" of the Ministry of Health of the Russian Federation, Nizhny Novgorod, Russia, Piskarev Yu.G. ,   Federal State Budgetary Educational Institution of Higher Education "Privolzhsky Research Medical University" of the Ministry of Health of the Russian Federation, Nizhny Novgorod, Russia, Tsaryapkin E.V. ,   Federal State Budgetary Educational Institution of Higher Education "Privolzhsky Research Medical University" of the Ministry of Health of the Russian Federation, Nizhny Novgorod, Russia
Published: February 2023

A comparative assessment of the physical development of students of two groups of 30 people (the first at the beginning of training, the second - after 2 years) was carried out at a military university. Anthropometric (body length and weight, chest circumference at rest, on inhalation and exhalation) and physimetric (hand strength, lung capacity (VC), heart rate (HR), systolic and diastolic pressure (SBP, DBP)) parameters were assessed . Calculated body mass index, index of functional changes. Daily energy expenditure was 3117.7±34.0 kcal, the energy value of the diet was 3081.1±75.1 kcal/day. Body weight at the beginning of training was lower by 2.7 kg (p=0.001), chest excursion by 4.9 cm (p=0.001), VC by 90.0 ml (p=0.01), heart rate less by 4, 6 beats/min (p=0.02), SBP over 4.8 per mm Hg. (p=0.01). According to individual data, more than one third of the persons of group No. 1 had hand strength in the range of 40-49 kg, in the main share - in the range from 50 to 55 kg, in a tenth part - in the range of more than 56-60 kg. In group 2, the proportion of persons with minimal hand strength differed by almost two times, and with the maximum - by 2.3 times. In group No. 1, in 16.6% of overweight individuals, BMI fluctuated in the range of 25.5÷27.7 units; in group No. 2 in 13.3% in the range of 25.02÷25.8 units. Growth and dynamics of body weight, muscle strength indicated an increase in active body weight and a decrease in the fat component. Organized life, nutrition, daily routine and the involvement of students in sports sections contribute to the development of physical qualities, increasing the adaptive capabilities of the body (the proportion of people with satisfactory adaptation is 4 times higher, functional stress is 1.6 times lower).
Current problems of rural population mortality in the Russian Federation
Authors:   The Federal State Budget Scientific Institution «The N. A. Semashko National Research Institute of Public Health», Moscow, Russia, Shchepin V. O. , Karpova O. B. ,   The Federal State Budget Scientific Institution «The N. A. Semashko National Research Institute of Public Health», Moscow, Russia, Zagoruychenko A. A. ,   The Federal State Budget Scientific Institution «The N. A. Semashko National Research Institute of Public Health», Moscow, Russia
Published: February 2023

Currently, the problem of mortality of the population is particularly relevant in Russia, especially in rural areas, as one of the reasons for which is the low level of availability of medical care. The purpose of the study is to analyze the causes of high mortality of the rural population of the Russian Federation and develop a set of measures aimed at reducing this indicator. The main materials were official statistics, modern sources of literature, regulatory documents. The methods of the conducted research included: informational-analytical, statistical, bibliographic. Statistical processing was carried out using software packages SPSS, Excel-2007. The analysis in 2017–2020 revealed an increase in the mortality rate of the Russian population in both urban and rural areas. Among the causes of deaths of rural residents in 2020, compared with 2019, there was an increase in almost all classes of diseases, except for deaths due to injuries and poisoning. At the same time, the probable reasons for the growth of these indicators in rural areas may be: low availability of medical care, lack of resource provision, the composition of the age structure of the rural population and demographic aging of the population in rural areas, migration processes. The results obtained reflect the particular importance of the problem of mortality of the rural population and can be used in the development of regional programs for demographic development of territories and subjects of the Russian Federation.
Osteogenic differentiation of canine adipose derived mesenchymal stem cells on B‐TCP and B‐TCP/Collagen biomaterials
Authors: Özgenç Özge , Özen Asuman
Published: February 2023

Mesenchymal stem cells are adult stem cells that can differentiate into osteogenic, chondrogenic, adipogenic and myogenic lineages. In orthopedics and traumatology, mesenchymal stem cells, combined with biomaterials, are used mainly for treating bone fractures and diseases in humans and animals. This study aims to promote the growth, proliferation, and osteogenic differentiation of mesenchymal stem cells isolated from the adipose tissue of canines on B‐TCP (Beta‐tricalcium phosphate) and B‐TCP/Collagen biomaterials. MTT analysis was performed to test the cell adhesion and proliferation on B‐TCP and B‐TCP/Collagen biomaterials used to mimic the extracellular matrix of three‐dimensional bone tissue. Scanning electron microscope analysis was performed to show general surface characters of BTCP and B‐TCP /Collagen biomaterials. The osteoinductive capacities of the BTCP and B‐TCP/Collagen biomaterials were determined by alkaline phosphatase and Von Kossa stainings, and RT‐PCR analysis. The ALP activity of the B‐TCP/Col containing material was significantly higher than the B‐TCP in the early days. In terms of gene expression, there were no significant differences except 14thday SPARC gene expression. The results of Von Kossa staining indicated that BTCP/ Col has above the desired level degradation capacity. As a result of this
research, although it is advantageous in terms of alkaline phosphatase activity and osteogenic gene expression compared to B‐TCP material, it is thought that B‐TCP/Collagen biomaterial should be developed for use in bone tissue engineering due to its high degradation property.
On four types of poets and four types of scholars: from pulavar to kavi in the changing intellectual landscape of Tamil Nadu
Authors: Chevillard Jean-Luc
Published: February 2023

Cet article examine le vocabulaire qui a été utilisé pour désigner les «professionnels du langage » au cours de l’histoire du tamoul, à l’intérieur de sa littérature ancienne, et tout spécialement dans les traités «grammaticaux » qui constituent le corpus shastrique Tamoul, et dans les thesauri (kōśa s), qui sont le corpus lexicographique. L’attention se porte principalement sur deux termes, pulavaṉ «savant, grammairien, poète » et kavi «poète » . Le premier,

pulavaṉ, est utilisé 80 fois dans le Tolkāppiyam, à l’époque du Sangam (Caṅkam), pour désigner ceux qui sont à l’origine de la codification (et de la grammatisation) de la langue tamoule poétique ancienne, mais il est aussi utilisé dans d’autres oeuvres pour désigner les poètes, créateurs de la litérature (qui peuvent être également interprètes). Le second, kavi, apparaît à une époque plus tardive, et les traités médiévaux le subdivisent en quatre sous-catégories, «poète rapide » , «poète doux » , «poète extrême » et «poète vaste » , dont les caractéristiques sont énumérées par les traités «grammaticaux » du genre pāṭṭiyal, ainsi que par les thesauri. Cette évolution à lieu devant un arrière-plan religieux, qui semble avoir joué un rôle important dans le maintien et l’évolution progressive d’une communauté de lettrés dont les compétences en matière de langage étaient la raison d’être aux yeux de la société tamoule.
Effect of working capital efficiency on profitability in companies in the cigarette industry sector on the Indonesian stock exchange in the 2003-2007 period
Authors: Supriyadi Rachmat Anggara
Published: February 2023

The purpose of this research is to know how efficiency of working capital (net working capital turnover) can give the influence the probability (return on assets) in cigarette company which listed in the INDONESIA Stock Exchange. This research is implemented to 4 cigarette company which listed in the INDONESIA Stock Exchange from 2003-2006. The companies are PT. H.M.Sampoerna, Tbk., PT Bentoel International Investama, Tbk., PT British American Tobacco Indonesia, Tbk.,PT. Gudang Garam, Tbk. Data financial is using as the object for this research is 4 years financial statements from 2003-2006. The data of this research which have been used are secondary data with population method, analysis method like simple regression analysis method. The result of this research is to confirm that efficiency of working capital (net working capital turnover) give the influence which is significant to effect profitability (return on assets).
Clinical characteristics of the dental status of patients with red lichen planus of the mucous membrane of the oral cavity
Authors: Bozhyk S.S.
Published: February 2023

The development of lichen planus (RLP) is associated with the action of various toxins, allergens, infectious agents, and disorders of the immune system. The aim of the work was to study the dental status of patients with RLP, its role in the development and course of the disease, and the impact on treatment outcomes. A clinical dental examination was carried out in 37 patients, including 31 women (83.78% of those examined) aged 33–65 years; 6 men 16.22%, aged 23 to 52 years. By the time of the initial visit, indicators of the intensity and prevalence of caries, the presence of non-carious lesions, dentoalveolar anomalies and deformities, hygienic and periodontal indicators were recorded. Dental deformities and anomalies of the soft tissues of the oral cavity were diagnosed in 59.46% of all examined patients of both sexes, wedge-shaped defects – in 24.32% of all examined patients of both sexes, pathological wear – in 18.92% of all examined patients. The intensity of caries was 7.89±0.46. The Green-Vermillion hygiene index was (2.13±0.05) points. The prevalence of inflammatory and dystrophic-inflammatory changes in periodontal tissues at the time of the initial examination at the dentist was (83.78±6.39) %, which allows us to state a high degree of compromise of periodontal tissues. The papillary-marginal-alveolar index (PMA) was (26.95±2.70) %, which corresponds to moderate gingivitis, and the Muhlemann-Saxer papillary bleeding index (PBI) was (1.40±0.14) points. The results obtained regarding the age and sex distribution of patients with RLP agree with the developments of foreign scientists of recent years, indicating a high activity of the manifestation of this disease in women of perimenopausal age, in particular, endocrine changes in women, especially in the production of sex steroids. The presence of aggravated dental status is a local risk factor and serves as a mechanism that activates etiological factors and intensifies already existing changes. The results obtained indicate the need to develop a complex of professional and individual oral hygiene in patients with RLP, as well as the relationship between their dental status and changes in the oral mucosa.

Keywords: red lichen planus, dermatosis, precancer.
Exponential-Trigonometry Intuitionistic Fuzzy Divergence Measure
Authors:   Department of Mathematics, Deenbandhu Chhotu Ram University of Science and Technology, Murthal (Haryana), India, Boora Rozy , Tomar Dr. Vijay Prakash ,   Associate Professor, Department of Mathematics, Deenbandhu Chhotu Ram University of Science and Technology, Murthal (Haryana), India
Published: February 2023

Based on the exponential and trigonometry functions, a new divergence measure is introduced under the intuitionistic fuzzy environment. The Intuitionistic Fuzzy Divergence Measure is an indispensable instrument to calculate the variance between two intuitionistic fuzzy sets. Many attractive properties are displayed to enhance the value of introduced intuitionistic fuzzy divergence measure. Many existing divergence measures are reviewed with their counter-intuitive examples. Finally, the invented divergence measure is applicative in the field of medical deliverance to differentiate between diseases with nearby same symptoms, pattern recognition to categorize the unknown into one of the known pattern.
Complications of Loop Electrosurgical Excision Procedure Following Treatment of Cervical Intra-Epithelial Neoplasia 2 & 3
Authors: Satter Dr. Mst Rokeya , Hoque Dr. Md. Tozammel , Hoque Dr. Md. Mozammel , Rahman Dr. Md. Saidur
Published: February 2023

Background: The loop electrosurgical excision procedure (LEEP) is currently one of the most commonly used approaches to treat high grade cervical squamus intraepithelial lesion confirmed on colposcopic guided biopsy examination. Complications of electrosurgical excision procedure (LEEP) are rare. But in Bangladesh, we have very limited research-based information regarding this issue. Aim of the Study: The aim of the study was to assess the complications of loop electrosurgical excision procedure following treatment of cervical intra-epithelial neoplasia (CIN) 2 and 3. Methods: This descriptive cross-sectional study was conducted in OPD, Gynaecology and Obstetrics Department, Rangpur Medical College Hospital, Rangpur, Bangladesh during the period of July 2011 to June 2012. In total, 75 patients with CIN 2 and/or 3 were enrolled in this study as study subjects. The study was approved by the ethical committee of the mentioned hospital. Proper informed written consents were taken from all the participants before data collection. The criteria for inclusion were colposcopic guided biopsy revealing CIN 2 or 3 whose lesion remains confined to ectocervix. The least amount of power that will effectively perform the electrosurgery should be used, so as to minimize the risk to the patient’s normal tissues and ensure that the excised specimen is inacceptable condition for pathological assessment. Data analysis was done by using statistical package for social science (SPSS) 16 versions. Results: In analyzing the post procedure complications of the participants, we observed that, 64% participants were from vaginal discharge. Besides this 21%, 9%, 4% and 1% cases were found with pain, bleeding, fever and cervical stenosis consequently. Distributing persistence of vaginal discharge, 44% participants taken 5-10 days which was noticeable. Only 5.33% participants had vaginal discharge in between 21-25 days. In distributing persistence of pain, we observed that, 8% participants had taken 30 days to be cured which was the highest number of patients. Within one week, all the patients become free from fever. Cervical Stenosis occurred as a delayed complication during follow up at 9-12 months after LEEP in only 1(1.3%) case and occurred at 270th day. Conclusion: As per the findings of this study we can mention vaginal discharge as the most common complication for the cervical intra-epithelial neoplasia patients by treating loop electrosurgical excision procedure. Besides these, physicians should be aware about the sufferings of patients from pain and bleeding. Finally, we can conclude that, LEEP as an easy safe and acceptable treatment for high grade CIN with high cure rate.
Association of Recurrent Apthous Ulcer (RAU) with Stress among Individuals in Northern Part of Nigeria
Authors: Mohammed Dr. Najat Ibrahim , Hassan Mrs. Saadatu Dada , Harsha Dr. Alice
Published: February 2023

Considering the issue of recurrent apthous ulcers affecting individuals worldwide, knowledge of the significant associating triggering factor is an essential tool, which can be used to figure out the most challenging factor behind that can be further controlled or avoided in an effort to reduce the chance of re occurrence by taking proper precautions. This paper evaluates the association of recurrent apthous ulcers with stress and other possible triggering factors such as Allergy and diet, among individuals in the northern part of Nigeria, represented by 4 states which include, Kano, Zamfara, Maiduguri and Katsina states respectively. Age, occupation, gender, history of re occurrence, site of occurrence in the oral cavity, number, duration of ulcers and nature of healing were highly considered in the study. 75 structured questionnaires were distributed among individuals of both genders, out of which 71 were retrieved and 4 left unanswered. The research methodology uses both correlation and descriptive statistical analysis. Following data analysis, using correlation table, there is weak correlation between Apthous ulcer and stress with .012 covariance. The results were analyzed using SPSS 25.0 VERSION and displayed in the form of Graph and tables. In conclusion, necessary preventive measures were outlined and further research recommendation is suggested in light of creating more awareness about the effects and importance of prevention to be considered by the society.
Logics of Adoption of Perennial Crops in the Ivorian Forest Zone: The Case of Heveaculture in the Sub-Prefecture of Bonoua
Authors: Arnaud Gbocho Maxime
Published: February 2023

The aim of this study is to define the logics that favoured the adoption of rubber cultivation to the detriment of pineapple cultivation in the sub-prefecture of Bonoua. In a mixed study, we collected information from actors who, by virtue of their function and social position, are in a position to inform us of the realities on the ground. To this end, we conducted the study with local authorities, administrative bodies, people working with or related to rubber, and the youth of Bonoua. We also interviewed representatives of the Burkinabe communities of Bonoua and Tchantchevé. With regard to data collection techniques, we used documentary research, observation and semi-directive interviews. These data were collected using an interview guide and a questionnaire. Based on the empirical study, we traced the history of the shift from pineapple to rubber and defined the logics of adoption of rubber farming on the basis of the theory of social change. This research is part of the sociology of rural development.
In vitro Cytotoxic Activities of Catha edulis (Vahl) Forssk. Ex Endl. (Khat) Varieties from Kenya on Select Cancer Cell Lines
Authors: Ngeny Lilian C. , Keter Lucia K. , Irungu Beatrice N. , Kuria James M. , Mwikwabe Nicholas M. , Ondicho Joyce M. , Korir Richard K. , Mwitari Peter G. , Tolo Festus M. , Orwa Jennifer A.
Published: February 2023

Khat (Catha edulis (Vahl) Forssk.) is a herb from the Celastraceae family (also known as qat, gaad, or miraa). The leaves and stems are used medicinally and for recreational purposes. The communities that grow khat have identified different varieties based on perceived appearance and quality. This study aimed to evaluate the cytotoxicity of khat varieties grown in the Meru and Embu Counties of Kenya. Field studies were undertaken in the markets and farms in Meru and Embu Counties of Kenya to document and purchase local khat varieties. Dried khat was extracted with a 1:1 v/v MeOH: CH2Cl2 solvent and water. Cytotoxicity of extracts was determined in vitro by MTT assay against four normal and cancer cells namely; HeLa ATCC® CCL-2™, HCC1395 ATCC® CRL-2324™, Hep2 ATCC® CCL-23™, and Vero E6 ATCC® CRL-1586™. The khat varieties identified were Muti Mutiiri, Mugwanthingi, Gicheru, Karimi ka Nthiya, Muguka, Black colombo asili, Black mbaine, and white. The aqueous extracts of black colombo asili and black mbaine displayed the highest cytotoxic activity against HeLa cell lines having IC50 37.15 ± 1.75 µg/ml and 38.31 ± 2.05 µg/ml, respectively. Muguka and Muti Mutiiri varieties were not cytotoxic to the Vero E6 cell line with CC50 > 100 µg/ml. 75% (12/16) of extracts were cytotoxic to the Vero E6 cell line with CC50 ˂ 100 µg/ml. This study demonstrated that there is variability in activities between the identified khat varieties. Toxicity was observed in vitro due to observed cytotoxicity to the Vero E6 cell line.
Marketing Srategy of Tempe Crypics to Increase Income for MSME Group in Mulyasari Village, Losari District
Authors: Setiawan Dedy
Published: February 2023

The marketing strategy of the tempe chips MSMEin the village of Mulyasari does not yet have modern marketing skills. This has greatly affected business development, because if rely solely on sales by leaving it in small shops, it is feared that the sustainability of business will be threatened. The purpose of this research is to develop social media such as youtube, instagram, facebook, twitter and whatsaap to increase the income of MSME tempe chips in Mulyasari village. The research method used in this activity is Participatory Action Research. Researchers did social media design, implemented social media, and analyzed MSME tempe chips using existing social media. The results of the study found that the income of these tempe chips MSME obtained an increase of 36.05% from the previous profit. Initially, the monthly income of tempe chips MSME earned around Rp. 1,803,000. However, after using a modern marketing strategy using social media so that the tempe chips MSME business can earn a monthly profit of around Rp. 2. 453,000, then the income of this tempe chips MSME will increase by Rp. 650,000
Middle Class Community Religious Moderation in Buntet Village, Astanajapura District, Cirebon Regency
Authors: Rahman Hakim Arif
Published: February 2023

This study focuses on religious
moderation and the religious views of the middle
class community in Buntet Village, Astanajapura
District, Cirebon Regency. The purpose of this
research is to find out how the community's religious
condition and how religious views are, as well as their
relation to nationality. The methodology used in this
study used a qualitative descriptive analysis using in-depth interview techniques, document review,
observation, and holding focus group discussions.
The results found in this study indicate that religious
moderation for the Muslim middle class in Buntet
Village, Astanajapura District, Cirebon Regency is
quite good. In this village, there are no members of
the community who are anti-NKRI, anti-Pancasila,
and anti-UUD 1945. As well as the diversity of the
Muslim community in the Buntet area is classified as
moderate, because of their religious understanding
as developed by NU and Muhammadiyah
The Importance Of Involvement: Examining The Impact Of Somethinc’s Instagram Page On Future Purchase Intention
Authors: Hidayat Anas , Windria Khoirunnisaa Ulfah
Published: February 2023

Effective online marketing today is through social media, because the users are many and wide, therefore this research examines the marketing done on Instagram. The purpose of this study is to examine the effect of Brand Familiarity, Involvement on Brand’s Social Media, Attitude Towards Brand’s Social Media, and Future Purchase Intention towards Somethinc’s Instagram Page. This research uses purposive random sampling method. The data collection was done by distributing online questionnaires via google form with a total sample size of 250 people. AMOS 22.0 software was used to analyze the data. The result show that 1) Involvement on brand’s social media positively influences attitude towards the brand’s social media, 2) Involvement on a brand’s social media positively influences future purchase intention, 3) Attitude towards a brand’s social media positively influences future purchase intention, 4) Brand familiarity positively influences consumer involvement on brand’s social media.
The Influence of Social Media Influencer’s Trustworthiness on Engagement, Expected Value and Purchase Intention
Authors: Puteri Lefina Ziyan , Hidayat Anas
Published: February 2023

In this digital age, it is indisputable that the internet has become an essential part of human existence and has had a great impact on society. By having this condition, businesses may consider allocating budgets to use influencer marketing as a marketing strategy. This study aimed to examine whether followers' perception of a social media influencer's trustworthiness can lead to responses to the influencers' recommended brands, specifically brand engagement in self-concept, expected brand value, and intention to purchase recommended brands. This study used non-probability sampling with the criteria of Indonesians who follow an influencer. The data was gathered by distributing an online questionnaires via Google Form to a total of 264 respondents. The data analysis technique utilized is SEM, which was conducted using the AMOS 22 application. The results showed that perceived influencer trustworthiness positively influence brand engagement in self-concept, brand expected value and intention to purchase recommended brand. While, brand engagement in self-concept positively influence brand expected value and intention to purchase recommended brand. Also, brand expected value positively influence intention to purchase recommended brand. This research will assist in understanding how social media influencers' recommendations influence customers' perceptions and behavior patterns.
Social Deixis in the Novel “Gadis Pesisir” By Nunuk Y. Kusmiana Pragmatic Review
Authors: Ulina Beru Ginting Sri , Hayati Maulidiah Rina , Nisa Khairun
Published: February 2023

This study aims to describe the form of social deixis in the novel Gadis Pesisir by Nunuk Y. Kusmiana with a pragmatic review. The research approach used in this study uses a qualitative approach with descriptive analysis techniques. This research is a qualitative research with a descriptive method that examines social deixis in an Indonesian novel with a pragmatic review. The data collection technique used is literature study. The data sources in this study are primary data and secondary data, the primary data used researchers in research are sentences or paragraphs that have social deixis in the novel "Girl Pesisir " by Nunuk Y. Kusmiana, secondary data for compiling this research is in the form of several theory books. The results show that there are three hundred and eighty-five social deixis in the form of words and phrases. The results show that social deixis in the form of words is one hundred and forty-two while the social deixis in the form of phrases is two hundred and forty-three. Besides the researchers also found  two hundred and seventy-four in the form of maintaining language manners, sixty-seven differentiators of social identity, thirty-five differentiators of social level, and eleven making sentences effective.
Relationship Between Employee Satisfaction and Perceived Organization Support on Individul Performance: Job Involvement As a Mediating Variable at Sharia Commercial Bank In Makassar City
Authors: Musafir Musafir
Published: February 2023

The level of employee confidence in organizational support will be influenced by the evaluation of their experiences and observations about the way the organization treats its employees in general. This research and to analyze the effects of the satisfaction and perception of the employees on the organizational support on the job involvement and the performance of the employees. The research population comprised all the 463 employees in six Syariah Public Banks in Makassar City, and the total of 203 samples of each bank. The data collection was done by using questionnaires and then analyzed using the analysis of the Structural Equation Model (SEM) through the software of Amos version 22. The research results indicated that (1) the satisfaction of the employees had a positive and significant effect of the job involvement and the performance of the employees; (2) that the perception organizational support had an insignificant effect on the job involvement and performance of the employees; and (3) the Job involvement each had a positive and significant effect on the performance of the employees.
A Patient with Expanded Dengue Syndrom
Authors: Wulandari Kirnia Tri , Tikto Tikto
Published: February 2023

EDS is an atypical manifestation of dengue infection that affects a variety of organ systems including gastrointestinal, hepatic, neurological, cardiac, pulmonary, and renal. It is one of the leading causes of hospitalization and death in children. A number of hypotheses have been proposed, but multifactorial pathogenesis. Severe cases can be expressed with petechiae, epistaxis, gastrointestinal hemorrhage, ascites, pleural effuse, heart attack, hypotension, tachycardia, changes in consciousness, fulminant hepatitis, and myocarditis. EDS-shaped organ dysfunction may require multidisciplinary management support for aggressive and effective action. The baby girl, An.P, 10 months old, came to the ER with a high fever since 4 days before KRS. High fever accompanied by vomiting and diarrhea. From a physical examination, the general condition of mentis compost, pulse, and breathing within normal limits. There are no epistaxis. The laboratory showed platelets of 100,000 μ/L, hematocrit 35.5%, hemoglobin (Hb) 12.3g/dL. Patients are diagnosed with dengue fever. in the same case that occurs in Mexico this is a case where patients with fever and headache. Patients exhibit neurological damage in which cranial Computerized Axial Tomography (CAT) reveals severe cerebral edema. Platelets 143,000 μ /L, Hb 10.6 g / dL, reported serologic NS1 positive. Patients die five days after hospital admission.Low incidence of EDS due to asymptomatic and easily missed diagnosis. This case has multi-organ failure. neurological manifestations such as seizures and decreased consciousness, gastrointestinal manifestations such as ascites and gastrointestinal bleeding, lung manifestations such as dyspnea. Conditions worsen in a fast time.
Analysis of the Impact of the Covid-19 Pandemic on Indonesian Economic Growth
Authors: Harianja Dekha Dwi
Published: February 2023

The Covid-19 pandemic has had a significant impact on every line of life, especially in the economic sector. This study aims to analyze the impact of the Covid-19 pandemic on economic growth in Indonesia. The research method used in this research is descriptive qualitative method. The type of data used in this study is qualitative data, which is categorized into two types, namely primary data and secondary data. Sources of data obtained through library research techniques (library studies) which refers to sources available both online and offline such as: scientific journals, books and news sourced from trusted sources. These sources are collected based on discussion and linked from one information to another. Data collection techniques used in this study were observation, interviews and documentation. This data is analyzed and then drawn conclusions. Based on the analysis of the description above, it can be concluded that Covid-19 has greatly affected and had a bad impact on various economic sectors, resulting in a decline in economic growth in Indonesia. Indonesia's economic growth decreased by 2.41% as a result of the coronavirus outbreak. This will result in an increase in the level of the state budget deficit. APBN 2020 experienced an increase in the deficit figure by 6.27% of gross domestic product.
Analysis of the Influence of Dynamic Capabilities on Company Performance Mediated By Competitive Advantage
Authors: Yohanes Yohanes , Margaretha Farah , Sudibyo Yvonne Augustine
Published: February 2023

This research has a purpose to find out how the influence of Dynamic Capabilities, either directly or indirectly on Company Performance through Competitive advantage as a mediating variable. Design / methodology / approach – data collection in the form of distributing questionnaires to collect a sample of 309 manufacturing companies in Indonesia. In any case, to analyze the data, the analytical method used is the Structural Equation Model (SEM) to assign the phenomenon and the tool used is AMOS 22. The result of this research is that Dynamic Capabilities, affect the upgrade in Competitive Advantage significantly and positively. Dynamic Capabilities, affect the positive and significant upgrade in Company Performance. Competitive Advantage affects the Company's performance improvement positively and significantly. The mediating influence of Competitive advantage upgrades the influence of Dynamic Capabilities, on improving Company Performance. Practical implications – this research has shown that Dynamic Capabilities have affected Company Performance through the practice of Competitive Advantage. In any case, This research describes that the company's performance is influenced by different competitive priorities as well as internal capabilities and external capabilities. Originality / value - This research analyzes sustainable innovation predicated on dynamic capabilities in manufacturing companies in Indonesia, by collecting managers' perceptions of modification in the external environment that affect the adaptation and alignment of the company's maneuver, which has an impact on the applied business model.