bluuebunny/crossref_metadata_2025 huggingface dataset:
Meaning in Life Mediates Between Emotional Deregulation and Eating Disorders Psychopathology: A Research From the Meaning-Making Model of Eating Disorders
Authors: Marco Jose H. , Cañabate Montserrat , Martinez Cristina , Baños Rosa M. , Guillen Verónica , Perez Sandra
Published: March 2021

Emotional dysregulation, age, gender, and obesity are transdiagnostic risk factors for the development and maintenance of eating disorders (EDs). Previous studies found that patients with ED had less meaning in life than the non-clinical population, and that meaning in life acted as a buffer in the course of ED; however, to the data, there are no studies about the mediator role of meaning in life in association between the emotional dysregulation and the ED psychopathology.

Objective: To analyze the mediating role of meaning in life in the relationship between emotional dysregulation and the ED psychopathology in three samples with diverse risk factors for ED.

Method: Sample 1, n = 153 undergraduate young women; sample 2, n = 122 participants with obesity; and sample 3, n = 292 participants with ED. Multiple mediation analysis was performed.

Results: Sample 1: meaning in life showed a mediation effect between emotional dysregulation and the ED psychopathology (direct effect β = 0.390, p < 0.05) (indirect effect β = 0.227, p < 0.05), body satisfaction (direct effect β = −0.017, p < 0.05) (indirect effect β = −0.013, p < 0.01), and depression symptoms (direct effect β = 1.112, p < 0.001) (indirect effect β = 0.414, p < 0.001); sample 2: meaning in life showed a mediation effect between emotional dysregulation and binge eating and purging behaviors (direct effect β = 0.194, p < 0.01) (indirect effect β = 0.054, p < 0.05) and depression symptoms (direct effect β = 0.357, p < 0.001) (indirect effect β = 0.063, p < 0.05); sample 3: meaning in life showed a mediation effect between emotional dysregulation and the ED psychopathology (direct effect β = 0.884, p < 0.001) (indirect effect β = 0.252, p < 0.007), body satisfaction (direct effect β = −0.033, p < 0.05) (indirect effect β = −0.021, p < 0.001), borderline symptoms (direct effect β = 0.040, p < 0.001) (indirect effect β = 0.025, p < 0.001), and hopelessness (direct effect β = 0.211, p < 0.001) (indirect effect β = 0.087, p < 0.001).

Conclusions: These studies suggest the importance of considering meaning in life as a variable in the onset and maintenance of ED.
Prevalence of Shift Work Disorder: A Systematic Review and Meta-Analysis
Authors: Pallesen Ståle , Bjorvatn Bjørn , Waage Siri , Harris Anette , Sagoe Dominic
Published: March 2021

Objectives: No systematic review or meta-analysis concerning the prevalence of shift work disorder (SWD) has been conducted so far. The aim was thus to review prevalence studies of SWD, to calculate an overall prevalence by a random effects meta-analysis approach and investigate correlates of SWD prevalence using a random-effects meta-regression.

Methods: Systematic searches were conducted in ISI Web of Science, PsycNET, PubMed, and Google Scholar using the search terms “shift work disorder” and “shift work sleep disorder.” No restrictions in terms of time frame were used. Included studies had to present original data on the prevalence of SWD in an occupational sample published in English. A total of 349 unique hits were made. In all, 29 studies were finally included from which two authors independently extracted data using predefined data fields. The meta-regression included four predictors (diagnostic criteria, study country, type of workers, and sample size).

Results: The overall prevalence of SWD was 26.5% (95% confidence interval = 21.0–32.8). Cochran Q was 1,845.4 (df = 28, p < 0.001), and the I2 was 98.5%, indicating very high heterogeneity across the observed prevalence estimates. Diagnostic criteria (International Classification of Sleep Disorders-2 = 0, International Classification of Sleep Disorders-3 = 1) and sample size were inversely related to SWD prevalence.

Conclusions: The prevalence of SWD was high across the included studies. The between-study disparity was large and was partly explained by diagnostic criteria and sample size. In order to facilitate comparative research on SWD, there is a need for validation and standardization of assessment methodology as well as agreement in terms of sample restrictions.
Associations Between Fear of COVID-19, Affective Symptoms and Risk Perception Among Community-Dwelling Older Adults During a COVID-19 Lockdown
Authors: Han Madeline F. Y. , Mahendran Rathi , Yu Junhong
Published: March 2021

Fear is a common and potentially distressful psychological response to the current COVID-19 pandemic. The factors associated with such fear remains relatively unstudied among older adults. We investigated if fear of COVID-19 could be associated with a combination of psychological factors such as anxiety and depressive symptoms, and risk perception of COVID-19, and demographic factors in a community sample of older adults. Older adults (N= 413,Mage= 69.09 years,SD= 5.45) completed measures of fear of COVID-19, anxiety and depressive symptoms, and risk perception of COVID-19, during a COVID-19 lockdown. These variables, together with demographics, were fitted to a structural equation model. Anxiety and depressive symptoms were highly correlated with each other and were combined into the higher order latent variable of affective symptoms for analyses. The final model revealed that fear of COVID-19 was positively associated with psychological factors of affective symptoms and risk perception. Older age was associated with greater fear of COVID-19. Our findings showed that fear of COVID-19 can be a projection of pre-existing affective symptoms and inflated risk perceptions and highlighted the need to address the incorrect risk perceptions of COVID-19 and socio-affective issues among older adults in the community.
Tutor of Resilience: A Model for Psychosocial Care Following Experiences of Adversity
Authors: Giordano Francesca , Cipolla Alessandra , Ungar Michael
Published: March 2021

This article describes a model for training service providers to provide interventions that build resilience among individuals who have experienced adversity. The Tutor of Resilience model emphasizes two distinct dimensions to training: (1) transforming service providers' perceptions of intervention beneficiaries by highlighting their strengths and capacity for healing; and (2) flexibly building contextually and culturally specific interventions through a five-phase model of program development and implementation. Tutor of Resilience has been employed successfully with child and youth populations under stress in humanitarian settings where mental health and psychosocial support professionals are required to design and deliver interventions that enhance resilience among vulnerable children.
Individual and Combined Effects of Planting Date, Seeding Rate, Relative Maturity, and Row Spacing on Soybean Yield
Authors: Schmitz Peder K. , Kandel Hans J.
Published: March 2021

Planting date (PD), seeding rate (SR), relative maturity (RM) of cultivars, and row spacing (RS) are primary management factors affecting soybean (Glycine max (L.) Merr.) yield. The individual and synergistic effects of PD, SR, RM, and RS on seed yield and agronomic characteristics in North Dakota were herein investigated. Early and late PD, early and late RM cultivars, two SR (408,000 and 457,000 seed ha−1), and two RS (30.5 and 61 cm) were evaluated in four total environments in 2019 and 2020. Maximizing green canopy cover prior to the beginning of flowering improved seed yield. Individual factors of early PD and narrow RS resulted in yield increase of 311 and 266 kg ha−1, respectively. The combined factors of early PD, late RM, high SR, and narrow RS improved yield by 26% and provided a $350 ha−1 partial profit over conventional practices. Canopy cover and yield had relatively weak relationships with r2 of 0.36, 0.23, 0.14, and 0.21 at the two trifoliolate, four trifoliolate, beginning of flowering, and beginning of pod formation soybean growth stages, respectively. Producers in the most northern soybean region of the USA should combine early planting, optimum RM cultivars, 457,000 seed ha−1 SR, and 31 cm RS to improve yield and profit compared to current management practices.
Characterizing Sounds of Different Sources in a Commercial Broiler House
Authors: Yang Xiao , Zhao Yang , Qi Hairong , Tabler George T.
Published: March 2021

Audio data collected in commercial broiler houses are mixed sounds of different sources that contain useful information regarding bird health condition, bird behavior, and equipment operation. However, characterizations of the sounds of different sources in commercial broiler houses have not been well established. The objective of this study was, therefore, to determine the frequency ranges of six common sounds, including bird vocalization, fan, feed system, heater, wing flapping, and dustbathing, at bird ages of week 1 to 8 in a commercial Ross 708 broiler house. In addition, the frequencies of flapping (in wing flapping events, flaps/s) and scratching (during dustbathing, scratches/s) behaviors were examined through sound analysis. A microphone was installed in the middle of broiler house at the height of 40 cm above the back of birds to record audio data at a sampling frequency of 44,100 Hz. A top-view camera was installed to continuously monitor bird activities. Total of 85 min audio data were manually labeled and fed to MATLAB for analysis. The audio data were decomposed using Maximum Overlap Discrete Wavelet Transform (MODWT). Decompositions of the six concerned sound sources were then transformed with the Fast Fourier Transform (FFT) method to generate the single-sided amplitude spectrums. By fitting the amplitude spectrum of each sound source into a Gaussian regression model, its frequency range was determined as the span of the three standard deviations (99% CI) away from the mean. The behavioral frequencies were determined by examining the spectrograms of wing flapping and dustbathing sounds. They were calculated by dividing the number of movements by the time duration of complete behavioral events. The frequency ranges of bird vocalization changed from 2481 ± 191–4409 ± 136 Hz to 1058 ± 123–2501 ± 88 Hz as birds grew. For the sound of fan, the frequency range increased from 129 ± 36–1141 ± 50 Hz to 454 ± 86–1449 ± 75 Hz over the flock. The sound frequencies of feed system, heater, wing flapping and dustbathing varied from 0 Hz to over 18,000 Hz. The behavioral frequencies of wing flapping were continuously decreased from week 3 (17 ± 4 flaps/s) to week 8 (10 ± 1 flaps/s). For dustbathing, the behavioral frequencies decreased from 16 ± 2 scratches/s in week 3 to 11 ± 1 scratches/s in week 6. In conclusion, characterizing sounds of different sound sources in commercial broiler houses provides useful information for further advanced acoustic analysis that may assist farm management in continuous monitoring of animal health and behavior. It should be noted that this study was conducted with one flock in a commercial house. The generalization of the results remains to be explored.
The Effect of Removable Orthodontic Appliances on Oral Microbiota: A Systematic Review
Authors: Lucchese Alessandra , Bonini Chiara , Noviello Maddalena , Lupo Stanghellini Maria Teresa , Greco Raffaella , Peccatori Jacopo , Biella Antonella , Tassi Elena , Beretta Valeria , Ciceri Fabio , Marcolina Marta , Gherlone Enrico , Manuelli Maurizio
Published: March 2021

Background (1): Removable orthodontic appliances may favor plaque accumulation and oral microbe colonization. This might be associated with intraoral adverse effects on enamel or periodontal tissues. The proposed systematic review was carried out to evaluate qualitatively and quantitatively the microbiological changes occurring during orthodontic therapy with removable orthodontic appliances. Methods (2): PubMed, Cochrane Library, Embase, Web of Science, Scopus, Ovid Medline, and Dentistry and Oral Sciences Source were searched. The research included every article published up to January 2020. The Preferred Reporting Items for Reporting Systematic reviews and Meta Analyses (PRISMA) protocol and the “Swedish Council on Technology Assessment in Health Care Criteria for Grading Assessed Studies” (SBU) method were adopted to conduct this systematic review. Results (3): The current study has a moderate evidence, demonstrating that removable appliances do influence the oral microbiota. Significant alterations occur just 15 days after the beginning of therapy, independently from the type of appliance. Furthermore, the levels of oral pathogens decrease significantly or even returned to pre-treatment levels several months later the therapy end. Conclusions (4): This review suggests that orthodontic treatment with removable appliances induces changes to oral microflora, but these alterations might not be permanent.
Three-Dimensional Radiological Assessment of Ablative Margins in Hepatocellular Carcinoma: Pilot Study of Overlay Fused CT/MRI Imaging with Automatic Registration
Authors: Minami Yasunori , Minami Tomohiro , Ueshima Kazuomi , Yagyu Yukinobu , Tsurusaki Masakatsu , Okada Takuya , Hori Masatoshi , Kudo Masatoshi , Murakami Takamichi
Published: March 2021

Background: We investigate the feasibility of image fusion application for ablative margin assessment in radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) and possible causes for a wrong initial evaluation of technical success through a side-by-side comparison. Methods: A total of 467 patients with 1100 HCCs who underwent RFA were reviewed retrospectively. Seventeen patients developed local tumor progressions (LTPs) (median size, 1.0 cm) despite initial judgments of successful ablation referring to contrast-enhanced images obtained in the 24 h after ablation. The ablative margins were reevaluated radiologically by overlaying fused images pre- and post-ablation. Results: The initial categorizations of the 17 LTPs had been grade A (absolutely curative) (n = 5) and grade B (relatively curative) (n = 12); however, the reevaluation altered the response categories to eight grade C (margin-zero ablation) and nine grade D (existence of residual HCC). LTP occurred in eight patients re-graded as C within 4 to 30.3 months (median, 14.3) and in nine patients re-graded as D within 2.4 to 6.7 months (median, 4.2) (p = 0.006). Periablational hyperemia enhancements concealed all nine HCCs reevaluated as grade D. Conclusion: Side-by-side comparisons carry a risk of misleading diagnoses for LTP of HCC. Overlay fused imaging technology can be used to evaluate HCC ablative margin with high accuracy.
The Epithelial–Mesenchymal Transcription Factor SNAI1 Represses Transcription of the Tumor Suppressor miRNA let-7 in Cancer
Authors: Wang Hanmin , Chirshev Evgeny , Hojo Nozomi , Suzuki Tise , Bertucci Antonella , Pierce Michael , Perry Christopher , Wang Ruining , Zink Jeffrey , Glackin Carlotta A. , Ioffe Yevgeniya J. , Unternaehrer Juli J.
Published: March 2021

We aimed to determine the mechanism of epithelial–mesenchymal transition (EMT)-induced stemness in cancer cells. Cancer relapse and metastasis are caused by rare stem-like cells within tumors. Studies of stem cell reprogramming have linked let-7 repression and acquisition of stemness with the EMT factor, SNAI1. The mechanisms for the loss of let-7 in cancer cells are incompletely understood. In four carcinoma cell lines from breast cancer, pancreatic cancer, and ovarian cancer and in ovarian cancer patient-derived cells, we analyzed stem cell phenotype and tumor growth via mRNA, miRNA, and protein expression, spheroid formation, and growth in patient-derived xenografts. We show that treatment with EMT-promoting growth factors or SNAI1 overexpression increased stemness and reduced let-7 expression, while SNAI1 knockdown reduced stemness and restored let-7 expression. Rescue experiments demonstrate that the pro-stemness effects of SNAI1 are mediated via let-7. In vivo, nanoparticle-delivered siRNA successfully knocked down SNAI1 in orthotopic patient-derived xenografts, accompanied by reduced stemness and increased let-7 expression, and reduced tumor burden. Chromatin immunoprecipitation demonstrated that SNAI1 binds the promoters of various let-7 family members, and luciferase assays revealed that SNAI1 represses let-7 transcription. In conclusion, the SNAI1/let-7 axis is an important component of stemness pathways in cancer cells, and this study provides a rationale for future work examining this axis as a potential target for cancer stem cell-specific therapies.
Immunotherapy for ALK-Rearranged Non-Small Cell Lung Cancer: Challenges Inform Promising Approaches
Authors: Sankar Kamya , Nagrath Sunitha , Ramnath Nithya
Published: March 2021

Rearrangements in the Anaplastic Lymphoma Kinase (ALK) gene have been implicated in 5–6% of all non-small cell lung cancers. ALK-rearranged non-small cell lung cancers are sensitive to ALK-directed tyrosine kinase inhibitors, but generally resistant to single-agent immune checkpoint inhibitors. Here, we aim to describe the mechanisms of ALK aberrations in non-small cell lung cancer by which an immunosuppressed tumor microenvironment is created, leading to host immune evasion. We report pre-clinical and clinical studies evaluating novel immunotherapeutic approaches and describe the promises and challenges of incorporating immune-based treatments for ALK-rearranged non-small cell lung cancer.
Abundance of Microvascular Endothelial Cells Is Associated with Response to Chemotherapy and Prognosis in Colorectal Cancer
Authors: Oshi Masanori , Huyser Michelle R. , Le Lan , Tokumaru Yoshihisa , Yan Li , Matsuyama Ryusei , Endo Itaru , Takabe Kazuaki
Published: March 2021

The generation of pathologic, immature, and dysfunctional vessels by angiogenesis is a mechanism of metastasis that has been a therapeutic target for colorectal cancer (CRC). In this study, we investigated the clinical relevance of intra-tumoral microvascular endothelial (mvE) cells in CRC using the xCell algorithm on transcriptome. A total of 1244 CRC patients in discovery and validation cohorts were analyzed. We found that an abundance of mvE cells did not mirror angiogenesis but reflected mature blood vessels because it was significantly associated with a high expression of vascular stability-related genes, including sphingosine-1-phosphate receptor genes and pericytes. Epithelial–mesenchymal transition and myogenesis gene sets were enriched in mvE cell abundant CRC, while mvE cell-less CRC enriched cell proliferation, oxidative phosphorylation, and protein secretion gene sets. mvE cell abundant CRC was associated with infiltration of M2 macrophages, dendritic cells, and less gamma-delta T cells (all p < 0.001), but not with the interferon-γ response. mvE cell abundant CRC was significantly associated with worse patient survival in CRC. Interestingly, mvE cell abundant CRC was significantly associated with a high response rate to chemotherapy (p = 0.012) and worse patient survival for those that did not receive chemotherapy. However, there was no survival difference in patients who underwent chemotherapy. In conclusion, we estimated the abundance of mvE cells using the xCell algorithm on tumor transcriptome finding its association with the number of mature blood vessels in a tumor microenvironment and its ability to predict response to chemotherapy, thereby patient survival in CRC.
The TCGA Molecular Classification of Endometrial Cancer and Its Possible Impact on Adjuvant Treatment Decisions
Authors: Alexa Matthias , Hasenburg Annette , Battista Marco Johannes
Published: March 2021

Adjuvant treatment decisions for endometrial cancer (EC) are based on stage, the histological grade of differentiation, histological subtype, and few histopathological markers. The Proactive Molecular Risk Classifier for Endometrial Cancer (ProMisE) identified four risk groups of EC patients using a combination of immunohistochemistry and mutation analysis: Polymerase Epsilon exonuclease domain mutated (POLE EDM), mismatch repair deficient (MMRd), p53 wild-type/copy-number-low (p53 wt), and p53-mutated/copy-number-high (p53 abn). Patients allocated to the POLE or abnormal p53 expression subtype are faced with a significantly altered outcome possibly requiring a modified adjuvant treatment decision. Within this review, we summarize the development of ProMisE, characterize the four molecular subtypes, and finally discuss its value in terms of a patient-tailored therapy in order to prevent significant under or overtreatment.
miRNA Expression Characterizes Histological Subtypes and Metastasis in Penile Squamous Cell Carcinoma
Authors: Ayoubian Hiresh , Heinzelmann Joana , Hölters Sebastian , Khalmurzaev Oybek , Pryalukhin Alexey , Loertzer Philine , Heinzelbecker Julia , Lohse Stefan , Geppert Carol , Loertzer Hagen , Wunderlich Heiko , Bohle Rainer M. , Stöckle Michael , Matveev Vsevolod Borisovich , Hartmann Arndt , Junker Kerstin
Published: March 2021

Although microRNAs are described as promising biomarkers in many tumor types, little is known about their role in PSCC. Thus, we attempted to identify miRNAs involved in tumor development and metastasis in distinct histological subtypes considering the impact of HPV infection. In a first step, microarray analyses were performed on RNA from formalin-fixed, paraffin-embedded tumor (22), and normal (8) tissue samples. Microarray data were validated for selected miRNAs by qRT-PCR on an enlarged cohort, including 27 tumor and 18 normal tissues. We found 876 significantly differentially expressed miRNAs (p ≤ 0.01) between HPV-positive and HPV-negative tumor samples by microarray analysis. Although no significant differences were detected between normal and tumor tissue in the whole cohort, specific expression patterns occurred in distinct histological subtypes, such as HPV-negative usual PSCC (95 differentially expressed miRNAs, p ≤ 0.05) and HPV-positive basaloid/warty subtypes (247 differentially expressed miRNAs, p ≤ 0.05). Selected miRNAs were confirmed by qRT-PCR. Furthermore, microarray data revealed 118 miRNAs (p ≤ 0.01) that were significantly differentially expressed in metastatic versus non-metastatic usual PSCC. The lower expression levels for miR-137 and miR-328-3p in metastatic usual PSCC were validated by qRT-PCR. The results of this study confirmed that specific miRNAs could serve as potential diagnostic and prognostic markers in single PSCC subtypes and are associated with HPV-dependent pathways.
Arming Immune Cells for Battle: A Brief Journey through the Advancements of T and NK Cell Immunotherapy
Authors: Wendel Philipp , Reindl Lisa Marie , Bexte Tobias , Künnemeyer Leander , Särchen Vinzenz , Albinger Nawid , Mackensen Andreas , Rettinger Eva , Bopp Tobias , Ullrich Evelyn
Published: March 2021

The promising development of adoptive immunotherapy over the last four decades has revealed numerous therapeutic approaches in which dedicated immune cells are modified and administered to eliminate malignant cells. Starting in the early 1980s, lymphokine activated killer (LAK) cells were the first ex vivo generated NK cell-enriched products utilized for adoptive immunotherapy. Over the past decades, various immunotherapies have been developed, including cytokine-induced killer (CIK) cells, as a peripheral blood mononuclear cells (PBMCs)-based therapeutic product, the adoptive transfer of specific T and NK cell products, and the NK cell line NK-92. In addition to allogeneic NK cells, NK-92 cell products represent a possible “off-the-shelf” therapeutic concept. Recent approaches have successfully enhanced the specificity and cytotoxicity of T, NK, CIK or NK-92 cells towards tumor-specific or associated target antigens generated by genetic engineering of the immune cells, e.g., to express a chimeric antigen receptor (CAR). Here, we will look into the history and recent developments of T and NK cell-based immunotherapy.
A Profound Basic Characterization of eIFs in Gliomas: Identifying eIF3I and 4H as Potential Novel Target Candidates in Glioma Therapy
Authors: Krassnig Stefanie , Wohlrab Christina , Golob-Schwarzl Nicole , Raicht Andrea , Schatz Christoph , Birkl-Toeglhofer Anna Maria , Skofler Christina , Gantenbein Nadine , Leoni Marlene , Asslaber Martin , Leber Stefan L. , Mahdy-Ali Kariem , von Campe Gord , Mayer Marlene , Borenich Andrea , Weis Serge , Benesch Martin , Haybaeck Johannes
Published: March 2021

Glioblastoma (GBM) is an utterly devastating cerebral neoplasm and current therapies only marginally improve patients’ overall survival (OS). The PI3K/AKT/mTOR pathway participates in gliomagenesis through regulation of cell growth and proliferation. Since it is an upstream regulator of the rate-limiting translation initiation step of protein synthesis, controlled by eukaryotic initiation factors (eIFs), we aimed for a profound basic characterization of 17 eIFs to identify potential novel therapeutic targets for gliomas. Therefore, we retrospectively analyzed expressions of mTOR-related proteins and eIFs in human astrocytoma samples (WHO grades I–IV) and compared them to non-neoplastic cortical control brain tissue (CCBT) using immunoblot analyses and immunohistochemistry. We examined mRNA expression using qRT-PCR and additionally performed in silico analyses to observe the influence of eIFs on patients’ survival. Protein and mRNA expressions of eIF3B, eIF3I, eIF4A1, eIF4H, eIF5 and eIF6 were significantly increased in high grade gliomas compared to CCBT and partially in low grade gliomas. However, short OS was only associated with high eIF3I gene expression in low grade gliomas, but not in GBM. In GBM, high eIF4H gene expression significantly correlated with shorter patient survival. In conclusion, we identified eIF3I and eIF4H as the most promising targets for future therapy for glioma patients.
Effects of Different Post-Treatments on Arc Erosion Resistance of Cold-Sprayed AgC Composite Electric Contact
Authors: Li Jingyu , Zhou Xin , Liu Yan , Chen Yanming , Zhang Jun , Huang Renzhong , Tan Jun , Li Zhenggang , Yang Bing
Published: March 2021

Graphite-silver (AgC) composite materials are widely used in outdoor high-voltage electrical switchgear due to their combining properties of excellent conductivity and outstanding arc-suppressing performance. However, the methods for fabricating AgC composite materials still have some limitations. In this study, the cold spray technique was adopted to deposit AgC composite coatings with the optimized parameters on the copper substrate. Then, AgC coatings were annealed in the furnace and treated by laser scanning, respectively, to further improve the arc erosion resistance performance of the coatings. The results show that the phase structure and electrical resistance of AgC coatings were not influenced by the post-treatment process. Furthermore, excellent hydrophobic performance was obtained after surface laser scanning treatment. The laser scanning treatment exhibited favorable advantages in enhancing the arc erosion resistance of AgC coatings, which indicated the lowest arc erosion rate compared with the cold-sprayed and annealed coatings.
Two-Step Deposition of Silicon Oxide Films Using the Gas Phase Generation of Nanoparticles in the Chemical Vapor Deposition Process
Authors: Suk Jae-Ho , Hong Sung-Chun , Jang Gil-Su , Hwang Nong-Moon
Published: March 2021

Non-classical crystallization, in which charged nanoparticles (NPs) are the building blocks of film growth, has been extensively studied in chemical vapor deposition (CVD). Here, the deposition behavior of silicon oxide films by the two-step growth process, where NPs are generated in the gas phase at high temperature and deposited as films at low temperature, was studied in the CVD process. Although we supplied SiH4, H2, and N2, the deposited film turned out to be silicon oxide, which is attributed to relatively poor vacuum. Also, silicon oxide NPs were captured on transmission electron microscopy (TEM) carbon membranes of a copper grid for 10 s under various conditions. When the quartz tube with a conical nozzle was used, the size of nanoparticles increased drastically with increasing processing time (or delay time) and porous films with a rough surface were deposited. When the quartz tube without a nozzle was used, however, the size did not increase much with increasing processing time and dense films with a smooth surface were deposited. These results suggest that the size of nanoparticles is an important parameter for the deposition of dense films for two-step growth at low temperatures.
Formation of Interstitial Dislocation Loops by Irradiation in Alpha-Iron under Strain: A Molecular Dynamics Study
Authors: Bany Salman Mohammad , Emin Kilic Mehmet , Jaser Banisalman Mosab
Published: March 2021

The present work reports the formation of an interstitial dislocation loop with a lower primary knock-on atom (PKA) energy in alpha-iron under strain conditions by the use of molecular dynamics simulation. The study was conducted using a PKA energy of 1~10 keV and hydro-static strain from −1.4 to 1.6%. The application of 1.6% hydrostatic strain results in the formation of ½<111> dislocation loop with a low PKA of 3 keV. This result was associated with a threshold displacement energy decrement when moving from compression to tension strain, which resulted in more Frenkel pairs initiated at peak time. Furthermore, many of the initiated defects were energetically favorable by 2 eV in the form of the interstitial dislocation loop rather than a mono defect.
Body Composition as a Predictor of Toxicity and Prognosis in Patients with Diffuse Large B-Cell Lymphoma Receiving R-CHOP Immunochemotherapy
Authors: Guo Jiaxun , Cai Panpan , Li Pengfei , Cao Cong , Zhou Jing , Dong Lina , Yang Yan , Xuan Qijia , Wang Jingxuan , Zhang Qingyuan
Published: March 2021

Background: Our study measured the body composition of Diffuse large B-cell lymphoma (DLBCL) patients receiving rituximab with cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP) regimen by computed tomographic (CT) and assessed their correlation with treatment-related toxicity and other adverse outcomes. Methods: We retrospectively analyzed 201 DLBCL patients who underwent pre-treatment abdominal CT examination. CT images were used to assess body composition metrics at the third lumbar vertebrae including fat tissues and muscle. Based on the skeletal muscle area (SMA) and density (SMD), skeletal muscle index (SMI), skeletal muscle gauge (SMG = SMI × SMD) and lean body mass (LBM) were calculated. Also analyzed were the toxicity, adverse events and survival. Results: We found that SMG, SMD, SMI and LBM were correlated with any grade 3–4 toxicity, dose reduction, hospitalization or termination of the treatment due to immunochemotherapy and worse survival. However, multivariate analysis demonstrated SMG [progression-free survival (PFS): hazard ratio (HR), 2.889; 95% CI, 1.401–5.959; p = 0.004; overall survival (OS): HR, 2.655; 95% CI, 1.218–5.787; p = 0.014] was the best predictor of poor prognosis. Conclusions: SMG, SMD, SMI and LBM were identified as predictors of adverse reactions and poor survival. SMG was an innovative and valuable indicator of immunochemotherapy toxicity and other adverse outcomes. Additionally, it can be used to individualize antineoplastic drug dosing.
Assessment of High-Electrification UK Scenarios with Varying Levels of Nuclear Power and Associated Post-Fault Behaviour
Authors: Hadri Mohamed , Trovato Vincenzo , Bialecki Agnes , Merk Bruno , Peakman Aiden
Published: March 2021

Renewable integration into the electricity system of Great Britain (GB) is causing considerable demand for additional flexibility from plants. In particular, a considerable share of this flexibility may be dispatched to secure post-fault transient frequency dynamics. Pursuant to the unprecedented changes to the traditional portfolio of generation sources, this work presents a detailed analysis of the potential system-level value of unlocking flexibility from nuclear electricity production. A rigorous enhanced mixed integer linear programming (MILP) unit commitment formulation is adopted to simulate several generation-demand scenarios where different layers of flexibility are associated to the operation of nuclear power plants. Moreover, the proposed optimisation model is able to assess the benefit of the large contribution to the system inertial response provided by nuclear power plants. This is made possible by considering a set of linearised inertia-dependent and multi-speed constraints on post fault frequency dynamics. Several case studies are introduced considering 2050 GB low-carbon scenarios. The value of operating the nuclear fleet under more flexible paradigms is assessed, including environmental considerations quantified in terms of system-level CO2 emissions’ reduction.
Price-Response Matrices Design Methodology for Electrical Energy Management Systems Based on DC Bus Signalling
Authors: Bellinaso Lucas V. , Carvalho Edivan L. , Cardoso Rafael , Michels Leandro
Published: March 2021

Prosumers’ electrical installations (PEIs), as nanogrids and low-voltage microgrids, have gained importance in recent years following the development of standards such as the IEC 60364-8 series. In these systems, all distributed energy resources (DERs) are usually integrated using dc bus coupling. The IEC 60364-8-3 predicts an electrical energy management system (EEMS) for power-sharing. The overall research framework of this paper is the nanogrid power management, where complex algorithms are required, as well as the conventional state machines and hierarchical controls. However, the addition of new DERs in such systems is not straightforward due to the complicated parameter settings for energy usage optimization. A different control strategy, named price-based power management, has been conceived to make the EEMS scalable to include new sources and simplify parameterization. Since it is analogous to economic markets, most users understand the concepts and feel comfortable tuning parameters according to their own cost/benefits goals. This paper proposes a price-based power management algorithm for EEMS to automatically design the price-response matrices (PRMs). The PRMs are a way to organize power management, considering new DERs and variable price of energy. The main contribution is the methodology to design the PRMs. Experimental results are carried out to demonstrate the effectiveness of the proposed strategy. The results were obtained with a 1.5 kW prototype composed of a PV generator, battery energy storage, loads, and grid connection.
An Intelligent Task Scheduling Mechanism for Autonomous Vehicles via Deep Learning
Authors: Balasekaran Gomatheeshwari , Jayakumar Selvakumar , Pérez de Prado Rocío
Published: March 2021

With the rapid development of the Internet of Things (IoT) and artificial intelligence, autonomous vehicles have received much attention in recent years. Safe driving is one of the essential concerns of self-driving cars. The main problem in providing better safe driving requires an efficient inference system for real-time task management and autonomous control. Due to limited battery life and computing power, reducing execution time and resource consumption can be a daunting process. This paper addressed these challenges and developed an intelligent task management system for IoT-based autonomous vehicles. For each task processing, a supervised resource predictor is invoked for optimal hardware cluster selection. Tasks are executed based on the earliest hyper period first (EHF) scheduler to achieve optimal task error rate and schedule length performance. The single-layer feedforward neural network (SLFN) and lightweight learning approaches are designed to distribute each task to the appropriate processor based on their emergency and CPU utilization. We developed this intelligent task management module in python and experimentally tested it on multicore SoCs (Odroid Xu4 and NVIDIA Jetson embedded platforms). Connected Autonomous Vehicles (CAV) and Internet of Medical Things (IoMT) benchmarks are used for training and testing purposes. The proposed modules are validated by observing the task miss rate, resource utilization, and energy consumption metrics compared with state-of-art heuristics. SLFN-EHF task scheduler achieved better results in an average of 98% accuracy, and in an average of 20–27% reduced in execution time and 32–45% in task miss rate metric than conventional methods.
Appropriate Reference Genes for RT-qPCR Normalization in Various Organs of Anemone flaccida Fr. Schmidt at Different Growing Stages
Authors: Zhao Zeying , Zhou Hanwen , Nie Zhongnan , Wang Xuekui , Luo Biaobiao , Yi Zhijie , Li Xinghua , Hu Xuebo , Yang Tewu
Published: March 2021

Anemone flaccida Fr. Schmidt is a traditional medicinal herb in southwestern China and has multiple pharmacological effects on bruise injuries and rheumatoid arthritis (RA). A new drug with a good curative effect on RA has recently been developed from the extract of A. flaccida rhizomes, of which the main medicinal ingredients are triterpenoid saponins. Due to excessive exploitation, the wild population has been scarce and endangered in a few of its natural habitats and research on the cultivation of the plant commenced. Studies on the gene expressions related to the biosynthesis of triterpenoid saponins are not only helpful for understanding the effects of environmental factors on the medicinal ingredient accumulations but also necessary for monitoring the herb quality of the cultivated plants. Reverse transcription quantitative polymerase chain reaction (RT-qPCR) as a sensitive and powerful technique has been widely used to detect gene expression across tissues in plants at different stages; however, its accuracy and reliability depend largely on the reference gene selection. In this study, the expressions of 10 candidate reference genes were evaluated in various organs of the wild and cultivated plants at different stages, using the algorithms of geNorm, NormFinder and BestKeeper, respectively. The purpose of this study was to identify the suitable reference genes for RT-qPCR detection in A. flaccida. The results showed that two reference genes were sufficient for RT-qPCR data normalization in A. flaccida. PUBQ and ETIF1a can be used as suitable reference genes in most organs at various stages because of their expression stabilitywhereas the PUBQ and EF1Α genes were desirable in the rhizomes of the plant at the vegetative stage.
Maternal Lineages from 10–11th Century Commoner Cemeteries of the Carpathian Basin
Authors: Maár Kitti , Varga Gergely I. B. , Kovács Bence , Schütz Oszkár , Maróti Zoltán , Kalmár Tibor , Nyerki Emil , Nagy István , Latinovics Dóra , Tihanyi Balázs , Marcsik Antónia , Pálfi György , Bernert Zsolt , Gallina Zsolt , Varga Sándor , Költő László , Raskó István , Török Tibor , Neparáczki Endre
Published: March 2021

Nomadic groups of conquering Hungarians played a predominant role in Hungarian prehistory, but genetic data are available only from the immigrant elite strata. Most of the 10–11th century remains in the Carpathian Basin belong to common people, whose origin and relation to the immigrant elite have been widely debated. Mitogenome sequences were obtained from 202 individuals with next generation sequencing combined with hybridization capture. Median joining networks were used for phylogenetic analysis. The commoner population was compared to 87 ancient Eurasian populations with sequence-based (Fst) and haplogroup-based population genetic methods. The haplogroup composition of the commoner population markedly differs from that of the elite, and, in contrast to the elite, commoners cluster with European populations. Alongside this, detectable sub-haplogroup sharing indicates admixture between the elite and the commoners. The majority of the 10–11th century commoners most likely represent local populations of the Carpathian Basin, which admixed with the eastern immigrant groups (which included conquering Hungarians).
Sleep Problems among Disaster Victims: A Long-Term Survey on the Life Changes of Disaster Victims in Korea
Authors: Kim Yujeong , Lee Haeyoung
Published: March 2021

This study aimed to assess sleep problems and their underlying factors in victims of disasters such as typhoons, heavy rains, fires, and earthquakes. Data from the long-term survey on life changes among disaster victims in 2019 obtained by the National Disaster Management Research Institute were used. The study included 1358 victims of natural and social disasters in Korea between 2012 and 2018. Sleep problems were assessed using a survey on subjective sleep quality and the use of sleeping medication. The data were analyzed using the chi-square test, t-test, and binominal logistic regression. The results showed that the factors affecting subjective sleep quality included disaster type, time elapsed after disaster, subjective health status, depression, and posttraumatic stress disorder. The factors affecting sleep medication use included age, time elapsed after disaster, and posttraumatic stress disorder. Therefore, interventions and support systems should be provided to prevent the prolongation of sleep problems.
Determinants of Population-Based Cancer Screening Performance at Primary Healthcare Institutions in China
Authors: Zheng Senshuang , Zhang Xiaorui , Greuter Marcel J. W. , de Bock Geertruida H. , Lu Wenli
Published: March 2021

Background: For a decade, most population-based cancer screenings in China are performed by primary healthcare institutions. To assess the determinants of performance of primary healthcare institutions in population-based breast, cervical, and colorectal cancer screening in China. Methods: A total of 262 primary healthcare institutions in Tianjin participated in a survey on cancer screening. The survey consisted of questions on screening tests, the number of staff members and training, the introduction of the screening programs to residents, the invitation of residents, and the number of performed screenings per year. Logistic regression models were used to analyze the determinants of performance of an institution to fulfil the target number of screenings. Results: In 58% and 61% of the institutions between three and nine staff members were dedicated to breast and cervical cancer screening, respectively, whereas in 71% of the institutions ≥10 staff members were dedicated to colorectal cancer screening. On average 60% of institutions fulfilled the target number of breast and cervical cancer screenings, whereas 93% fulfilled the target number for colorectal cancer screening. The determinants of performance were rural districts for breast (OR = 5.16 (95%CI: 2.51–10.63)) and cervical (OR = 4.17 (95%CI: 2.14–8.11)) cancer screenings, and ≥3 staff members dedicated to cervical cancer screening (OR = 2.34 (95%CI: 1.09–5.01)). Conclusions: Primary healthcare institutions in China perform better in colorectal than in breast and cervical cancer screening, and institutions in rural districts perform better than institutions in urban districts. Increasing the number of staff members on breast and cervical cancer screening could improve the performance of population-based cancer screening.
The Impact of Multiple Sclerosis Disease Status and Subtype on Hematological Profile
Authors: Miller Jacob M. , Beales Jeremy T. , Montierth Matthew D. , Briggs Farren B. , Frodsham Scott F. , Davis Mary Feller
Published: March 2021

Multiple sclerosis (MS) is an immune-mediated, demyelinating disease of the central nervous system. In this study, an MS cohort and healthy controls were stratified into Caucasian and African American groups. Patient hematological profiles—composed of complete blood count (CBC) and complete metabolic panel (CMP) test values—were analyzed to identify differences between MS cases and controls and between patients with different MS subtypes. Additionally, random forest models were used to determine the aggregate utility of common hematological tests in determining MS disease status and subtype. The most significant and relevant results were increased bilirubin and creatinine in MS cases. The random forest models achieved some success in differentiating between MS cases and controls (AUC values: 0.725 and 0.710, respectively) but were not successful in differentiating between subtypes. However, larger samples that adjust for possible confounding variables, such as treatment status, may reveal the value of these tests in differentiating between MS subtypes.
NLRP3 Inflammasome: Potential Role in Obesity Related Low-Grade Inflammation and Insulin Resistance in Skeletal Muscle
Authors: Jorquera Gonzalo , Russell Javier , Monsalves-Álvarez Matías , Cruz Gonzalo , Valladares-Ide Denisse , Basualto-Alarcón Carla , Barrientos Genaro , Estrada Manuel , Llanos Paola
Published: March 2021

Among multiple mechanisms, low-grade inflammation is critical for the development of insulin resistance as a feature of type 2 diabetes. The nucleotide-binding oligomerization domain-like receptor family (NOD-like) pyrin domain containing 3 (NLRP3) inflammasome has been linked to the development of insulin resistance in various tissues; however, its role in the development of insulin resistance in the skeletal muscle has not been explored in depth. Currently, there is limited evidence that supports the pathological role of NLRP3 inflammasome activation in glucose handling in the skeletal muscle of obese individuals. Here, we have centered our focus on insulin signaling in skeletal muscle, which is the main site of postprandial glucose disposal in humans. We discuss the current evidence showing that the NLRP3 inflammasome disturbs glucose homeostasis. We also review how NLRP3-associated interleukin and its gasdermin D-mediated efflux could affect insulin-dependent intracellular pathways. Finally, we address pharmacological NLRP3 inhibitors that may have a therapeutical use in obesity-related metabolic alterations.
Maintenance of Cell Wall Integrity under High Salinity
Authors: Liu Jianwei , Zhang Wei , Long Shujie , Zhao Chunzhao
Published: March 2021

Cell wall biosynthesis is a complex biological process in plants. In the rapidly growing cells or in the plants that encounter a variety of environmental stresses, the compositions and the structure of cell wall can be dynamically changed. To constantly monitor cell wall status, plants have evolved cell wall integrity (CWI) maintenance system, which allows rapid cell growth and improved adaptation of plants to adverse environmental conditions without the perturbation of cell wall organization. Salt stress is one of the abiotic stresses that can severely disrupt CWI, and studies have shown that the ability of plants to sense and maintain CWI is important for salt tolerance. In this review, we highlight the roles of CWI in salt tolerance and the mechanisms underlying the maintenance of CWI under salt stress. The unsolved questions regarding the association between the CWI and salt tolerance are discussed.