bluuebunny/crossref_metadata_2025 huggingface dataset:
Children's Oncology Group's 2023 blueprint for research: Pharmacy
Authors: Ostrenga Andrew R. , Thackray Jennifer , McLearan Ha‐Mill H. , Mulieri Kevin M. , Bisaccia Elizabeth , Militano Olga , Dupuis L. Lee , Bernhardt M. Brooke ,   the COG Pharmacy Discipline Steering Committee
Published: July 2023

Children's Oncology Group (COG) pharmacists and pharmacy technicians from more than 200 COG‐member institutions comprise the COG Pharmacy Discipline. Discipline members serve an essential role in the design and execution of COG clinical trials. Core activities include study drug management, study drug access, clinical trial operations, protocol harmonization, and direct patient care. Discipline members are also actively involved in continuing education, membership engagement, and research across other COG committees/domains. Future areas of committed growth for the discipline include pharmacogenomics, pharmacokinetics, pharmacoeconomics, pharmaceutics, and implementation science.
Thermal and morphological characterization of biowaste date palm fiber‐reinforced polybenzoxazine and epoxy composites
Authors: Abdelkawy Mahmoud A. , Itsuno Shinichi , El‐Badawi Mahmoud A. , Aly El‐Saied A.
Published: July 2023

Waste date palm fiber (DPF) has recently emerged as a promising natural fiber due to its abundance, renewability, and low cost. The study discussed the use of DPF as reinforcement in composites, particularly in polybenzoxazine (PBz), epoxy resin (EP), and their copolymer (EP‐co‐PBz) composites. The waste DPF underwent an alkaline treatment process, resulting in a high‐performance material that exhibits exceptional interaction with the matrix. The composite samples were fabricated using 5–20 wt% of alkali treated DPFs with polybenzoxazines and epoxy resins. The study examined the thermal and morphological properties of the resulting composites and found that they exhibited remarkable enhancements in various properties. For instance, the PNaphz‐COOH reinforced 5 wt% DPFs composite showed a significant increase in Td5% and Td10%, while the EP‐co‐PBz reinforced DPFs composites exhibited a remarkable increase in char yield (Yc). The SEM analysis of the composite surface further validated these findings, highlighting the remarkable interfacial bonding between the DPFs and the matrix. The remarkable enhancements in thermal properties demonstrated in this study open up new possibilities for utilizing waste DPF in various applications.

Highlights

Waste date palm fiber enhances thermosetting polymer reinforcement for high‐performance composites.

Alkaline treatment improves interfacial bonding between waste DPF and matrix.

Composites reinforced with waste DPF exhibit outstanding thermal and morphological properties.
How research on persuasion can inform dual-process models of judgment
Authors: Petty Richard E. , Wegener Duane T. , Briñol Pablo
Published: July 2023

De Neys makes some useful points regarding dual-process models, but his critique ignores highly relevant theories of judgment from the persuasion literature. These persuasion models predate and often circumvent many of the criticisms he makes of the dual-process approaches he covers. Furthermore, the persuasion models anticipated some of the correctives to dual-process models that he proposes.
Toward dual-process theory 3.0
Authors: Frankish Keith
Published: July 2023

This commentary is sympathetic to De Neys's revision of dual-process theory but argues for a modification to his position on exclusivity and proposes a bold further revision, envisaging a dual-process theory 3.0, in which system 1 not only initiates system 2 thinking but generates and sustains it as well.
Ethnomusicology, entrepreneurialism and the Western classical music student
Authors: Avis Rupert
Published: July 2023

This article explores the potential use of ethnomusicology in the development of entrepreneurialism amongst Western classical music students studying at UK music colleges. It is argued that both ‘doing’ and ‘reading’ ethnomusicology can encourage students to explore the diverse uses and meanings attached to Western classical music in varied social and geographic contexts. The knowledge garnered through ethnomusicology can then be applied in creative, informed and situational ways by students in the development of entrepreneurial strategies. As a by-product, it is suggested that ethnomusicology can be used to reframe entrepreneurialism as a musical, relational and interactive process.
Advantages of GSMaP Data for Multi‐Timescale Precipitation Estimation in Luzon
Authors: Lee Cheng‐An , Huang Wan‐Ru
Published: July 2023

The Global Precipitation Measurement Mission (GPM) provides two different sources of post‐real‐time satellite‐based rainfall estimates, including the Integrated Multi‐satellitE Retrievals for GPM Final Run (herein IMERG‐F) and Global Satellite Mapping of Precipitation‐Gauge (herein GSMaP‐G). However, relative to IMERG‐F, GSMaP‐G has been less thoroughly evaluated in the context of studying rainfall variations over Luzon, Philippines. Using rain‐gauge observations over Luzon as a reference base, this study aimed to clarify if GSMaP‐G v07 is more capable than IMERG‐F v06 in regard to representing rainfall variations over Luzon at multiple timescales (including intraseasonal, annual, and interannual). The results revealed that both IMERG‐F and GSMaP‐G performed better in regard to depicting the temporal phase evolution for the wet season rainfall than they did for the dry season rainfall for Luzon. However, relative to IMERG‐F, GSMaP‐G exhibited better performance in most examined features, including (a) the detection of temporal variations (both phase and amplitude) of rainfall on the intraseasonal, annual, and interannual timescales; (b) the representation of spatial differences with more rainfall occurring from April to September for western Luzon and from October to March for eastern Luzon; (c) the detection of occurrence of rainfall events at various intensities. The analysis also demonstrates that the difference between the performance of IMERG‐F and GSMaP‐G in regard to quantitative rainfall estimation is larger during the wet season than it is during the dry season. The possible cause for their performance differences over Luzon is the differences in the gauge‐adjustment method and the biases in its pre‐non‐gauge‐adjusted product.
Ride comfort and segmental vibration transmissibility analysis of an automobile passenger model under whole body vibration
Authors: Guruguntla Veeresalingam , Lal Mohit , Ghantasala G. S. Pradeep , Vidyullatha P. , Alqahtani Malak S. , Alsubaie Najah , Abbas Mohamed , Soufiene Ben Othman
Published: July 2023

The examination of seated occupants’ ride comfort under whole-body vibration is a complex topic that involves multiple factors. Whole-body vibration refers to the mechanical vibration that is transmitted to the entire body through a supporting surface, such as a vehicle seat, when traveling on rough or uneven surfaces. There are several methods to assess ride comfort under whole-body vibration, such as subjective assessments, objective measurements, and mathematical models. Subjective assessments involve asking participants to rate their perceived level of discomfort or satisfaction during the vibration exposure, typically using a numerical scale or questionnaire. Objective measurements include accelerometers or vibration meters that record the actual physical vibrations transmitted to the body during the exposure. Mathematical models use various physiological and biomechanical parameters to predict the level of discomfort based on the vibration data. The examination of seated occupants ride comfort under whole-body vibration has been of great interest for many years. In this paper, a multi-body biomechanical model of a seated occupant with a backrest is proposed to perform ride comfort analysis. The novelty of the present model is that it represents complete passenger by including thighs, legs, and foot which were neglected in the past research. A multi-objective firefly algorithm is developed to evaluate the biomechanical parameters (mass, stiffness and damping) of the proposed model. Based on the optimized parameters, segmental transmissibilities are calculated and compared with experimental readings. The proposed model is then combined with a 7-dofs commercial car model to perform a ride comfort study. The ISO 2631-1:1997 ride comfort standards are used to compare the simulated segmental accelerations. Additionally, the influence of biomechanical parameters on most critical organs is analyzed to improve ride comfort. The outcomes of the analysis reveal that seated occupants perceive maximum vibration in the 3–6 Hz frequency range. To improve seated occupants' ride comfort, automotive designers must concentrate on the pelvis region. The adopted methodology and outcomes are helpful to evaluate protective measures in automobile industries. Furthermore, these procedures may be used to reduce the musculoskeletal disorders in seated occupants.
Nevus Spilus With Dermatoheliosis: A Histologic Mimicker of Melanoma in Situ at Melanoma Excision Margins
Authors: Sheridan Connor , O'Connor Megan C. , Sitton Beau , Bass Jonathan , Shahwan Kathryn T. , Carr David R.
Published: July 2023

Nevus spilus, or speckled lentiginous nevus, is a relatively common lesion that presents at birth or in early childhood. It consists of a background tan patch, which appears similar to a café au lait macule or lentigo simplex on histology, studded with various types of nevi. Rarely, these nevi can undergo malignant transformation to melanoma. When melanoma develops within a heavily photodamaged nevus spilus, evaluating excision margins may be challenging because the combined histologic features of nevus spilus and severe dermatoheliosis can mimic melanoma in situ. We report a case of an elderly man with extensive sun damage who developed malignant melanoma within an occult nevus spilus, resulting in multiple excisions with false-positive margins.
BILATERAL RETINAL HEMORRHAGES AFTER SEQUENTIAL ENDOVASCULAR TREATMENT OF BILATERAL UNRUPTURED CEREBRAL ANEURYSMS
Authors: Liu Tianyu , Tsui Jonathan C. , Choudhri Omar A. , Kim Benjamin J. , Brucker Alexander J.
Published: July 2023

Purpose:

To report a case of bilateral retinal hemorrhages in a patient undergoing two separate endovascular interventions for bilateral cerebral aneurysms.

Methods:

A comprehensive ophthalmic examination was performed after the patient underwent each of two separate endovascular interventions for bilateral cerebral aneurysms. Multimodal imaging including widefield pseudocolor fundus photography, optical coherence tomography, and widefield fluorescein angiography was obtained. A systemic workup including genetic testing and hypercoagulability studies was performed.

Results:

Dilated fundus examination revealed new visually significant ipsilateral retinal hemorrhages after each endovascular procedure. Fluorescein angiography showed evidence of a peripheral retinal microangiopathy present in both eyes before the patient underwent her second endovascular procedure. Systemic workup revealed persistently elevated serum anticardiolipin IgM antibody levels at >99th percentile.

Conclusion:

Retinal complications after endovascular intracranial interventions are uncommon. This patient who developed bilateral retinal complications was found to have persistently elevated anticardiolipin antibody levels, a risk factor for thrombosis. Patients who develop retinal complications after endovascular intracranial intervention may benefit from systemic workup for hypercoagulable conditions.
FUNGAL ENDOPHTHALMITIS MASQUERADING AS SYMPATHETIC OPHTHALMIA
Authors: Hang Abraham , Ruiz Jonathan , Park Susanna S. , Homer Natalie A. , Kim Esther , Moussa Kareem
Published: July 2023

Purpose:

To describe the ocular pathology of a patient with fungal endophthalmitis with features mimicking sympathetic ophthalmia.

Methods:

Review of medical records and histopathology of a single patient.

Results:

A 72-year-old man who sustained penetrating injury to the left eye with an agave plant presented to our clinic 16 months after the initial injury. Before presentation, the patient had developed endophthalmitis and had undergone anterior chamber washout, vitrectomy, and intravitreal steroids, antibiotics, antifungals, and anti–vascular endothelial growth factor therapy. At presentation, the patient had a blind, painful eye and subsequently underwent enucleation. Histopathology demonstrated granulomatous inflammation with multinucleated giant cells in the iris and Dalen–Fuchs nodules with CD68-positive epithelioid histiocytes associated with the retinal pigment epithelium sparing the choriocapillaris. These findings were initially attributed to sympathetic ophthalmia. The fellow eye did not have any signs of inflammation, and Grocott methenamine silver stain was positive for filamentous fungal elements, leading to a diagnosis of fungal endophthalmitis.

Conclusions:

Fungal endophthalmitis may develop histopathologic features that are similar to those observed in sympathetic ophthalmia. Recognition of the overlap between the histopathologic features of these diseases may reduce the possibility of misdiagnosis and unnecessary treatment of the fellow eye.
The influence of sex on the treatment of postural tachycardia syndrome in children
Authors: Peng Yali , Wang Shuo , Zou Runmei , Cai Hong , Zhang Juan , Wang Yuwen , Wang Cheng
Published: July 2023

There are differences in postural tachycardia syndrome (POTS) incidence and manifestations in children between the sexes. However, there is limited evidence on how the gender affects the prognosis of POTS in children. This study is aimed at exploring the differences between the sexes regarding the prognosis of children with POTS. A retrospective study was conducted on children (n = 53; aged 6–14 years) who were diagnosed with POTS. All the POTS patients were given health education and autonomic function training, their water and salt intake was increased (oral rehydration salt III, 250 mL, Bid), and they were administered oral metoprolol (1 mg/kg per day) for 3 months. The prognosis was defined by the head-up tilt test results after treatment. It was observed that male and female children exhibited different trends in POTS prognosis. Further, the sex showed a stable independent effect on prognostic in children with POTS. To elaborate, females had a 503% increased risk of poor prognosis compared to males. We hence hypothesize that there is an association between the sex and the POTS prognosis in children. Female patients have a significantly higher risk of poor prognosis compared to males. A slight increase in the dose of oral rehydration salt could help lower the risk of poor prognosis in children with POTS. A higher absorption of total metoprolol, lower local concentrations, and slower metabolic excretion are documented in research in female POTS patients during treatment. It is recommended that the optimal dose of metoprolol should be lowered in female children undergoing treatment, to limit the risk of poor prognosis.
Inter‐habitat community variation of butterflies in an Afrotropical region
Authors: Onyenweaku Levi N. , Nwankwo Emmanuel C. , Ezealor Augustine U.
Published: July 2023

The impact of habitat disturbance on butterfly species assemblage in the Afrotropical region was studied by investigating inter‐habitat community variation of butterflies. Distinct butterfly species assemblages were found across surveyed habitat types, with 1554 adult butterflies of 126 species from five families recorded. The Primary forests had the highest species diversity and a higher dissimilarity between the Secondary and Plantation Forests. Of the 126 species recorded, 80 species were unique to one habitat. We provide new insights into butterfly ecology in the region, which can inform the development of conservation strategies to protect these ecosystems.
Sin, shame, and the subject
Authors: Jorgenson Allen G.
Published: July 2023

In this chapter I revisit construals of sin and shame, beginning with a moment of auto‐investigation. I then set this data in conversation with historical, theological, and philosophical configurations of shame to reconceive sin and shame. I describe sin as curvatus ex carne (turning from the flesh) to signal sin as a refusal of both our embodied existence and a commodification of the land on which it lives. I then use a carnal hermeneutic to argue for a positive understanding of discerning shame as a resource for an ethical life that contrasts with shame of disgrace.
Habitat suitability and centrality—not peripherality—predict demographic performance in a Neotropical lizard
Authors: Nappo Humberto Coelho , Campelo Pedro Henrique , Machado Laís Pio Caetano , Cavalcante Vitor Hugo Gomes Lacerda , Colli Guarino Rinaldi
Published: July 2023

Aim

The centre–periphery hypothesis (CPH) sustains that peripheral populations are subjected to harsher environmental conditions, which reduces demographic performance manifested, among others, by lower abundance, higher inbreeding and higher developmental instability. However, range centrality/peripherality is not necessarily a good proxy for environmental suitability since geographical distributions are often irregular in shape, barriers may limit dispersal towards suitable areas, and ancestral range shifts may have occurred unevenly in each direction. We evaluated predictions of the CPH for populations of the Neotropical lizard Notomabuya frenata by modelling the effects of environmental suitability and geographical centrality/peripherality upon demographic performance.

Location

Brazilian Cerrado.

Taxon

Notomabuya frenata (Squamata, Scincidae).

Methods

We used populational values of body size, body mass, body condition, tail autotomy and fluctuating asymmetry (FA; a proxy of developmental instability) to estimate demographic performance. Then, we built correlative models to estimate environmental suitability for each sampled population. Finally, we used hierarchical Bayesian models based on a combination of stochastic partial differential equations and integrated nested Laplace approximations to model the relationships between demographic performance and predictor variables (geographical centrality/peripherality and environmental suitability) and make predictions across the geographical distribution of N. frenata.

Results

Generalized boosting produced the best environmental suitability models. The total suitability area spanned more than 4 million km2 in cis‐Andean South America. All scalation counts presented some degree of asymmetry. Only three response variables—all related to FA—responded significantly to predictor changes. Contrary to the predictions of the CPH, one scalation count presented higher asymmetry closer to the range center and another in more suitable environments. Peripherality did not significantly influence any of the response variables.

Main Conclusions

Populations may respond differently to geographical centrality/peripherality and environmental suitability, as these characteristics do not necessarily coincide. Studies testing the CPH should ideally incorporate these different predictors of demographic performance.
When Kids Are a Burden: Understanding the Normative Sources of Negative Perceptions of Parenthood
Authors: Han Sinn Won
Published: July 2023

How individuals perceive raising children varies across countries. Researchers seeking to explain this have tended to focus on variation in family policies across countries, arguing that having children is perceived more negatively in terms of cost and disturbance to parents’ freedom and careers in countries where less policy support for families is provided. In this study, I add to the literature on attitudes toward child‐raising by focusing on a key feature of the cultural context: societal gender‐role norms. I posit that greater normative expectations in favor of women's “dual” responsibilities of being wage earners and devoted mothers are associated with more negative perceptions of parenthood. Using internationally comparative data drawn from 27 OECD countries, I find that in countries where the dual role expectation is established as a dominant cultural norm for women, people are more likely to perceive children as a burden. This pattern is particularly pronounced among women, who must contend with the dual expectations of contributing to family income while assuming the responsibility of primary caregiver. Furthermore, I find that between‐country differences in the normative context play a larger role than the policy context in explaining variation in the perceived costs/disruptiveness of children across countries.
Investigation of Steel I-Beams Strengthened Using CFRP and BFRP Sheets under Torsion
Authors: Aydin Emine
Published: July 2023

Torsional demand acting on beams can significantly effect structural behavior and cause high-local stresses. The torsional resistance of beams can be potentially increased by using fiber-reinforced polymer (FRP) sheets. In this study, basalt (BFRP) and carbon (CFRP) fabrics with different layouts are used to strength the steel I-beams, and the enhancement in the torsional strength is investigated experimentally and numerically. First, 12 specimens are reinforced using BFRP and CFRP fabrics bonded to the web of steel I-beams in three different layouts to carry out the experimental study. In total, 14 specimens are tested under torsion including two reference beams. Second, a numerical model is developed to capture the torsional behavior of web-reinforced steel beams. After the numerical model is verified satisfactorily, a parametric study is conducted to evaluate the effect of FRP strengthening on steel beams for flange-only and full reinforcement alternatives. In the experiments, fully web-bonded FRP strengthening configuration achieved 18% and 14% increase in torsional capacities for BFRP and CFRP sheets compared to reference, respectively. In last, it is discovered by the parametric study that the full reinforcement using FRP on the web and flanges can achieve up to 43% increase.
Supplementary Table S5 from Phase I trial of Ganitumab plus Dasatinib to Cotarget the Insulin-Like Growth Factor 1 Receptor and Src Family Kinase YES in Rhabdomyosarcoma
Authors: Akshintala Srivandana , Sundby R. Taylor , Bernstein Donna , Glod John W. , Kaplan Rosandra N. , Yohe Marielle E. , Gross Andrea M. , Derdak Joanne , Lei Haiyan , Pan Alexander , Dombi Eva , Palacio-Yance Isabel , Herrera Kailey R. , Miettinen Markku M. , Chen Helen X. , Steinberg Seth M. , Helman Lee J. , Mascarenhas Leo , Widemann Brigitte C. , Navid Fariba , Shern Jack F. , Heske Christine M.
Published: July 2023

Summary statistics for nucleosome footprints at YES1 and IGF1R regulatory motifs
Supplementary Table S2 from Phase I trial of Ganitumab plus Dasatinib to Cotarget the Insulin-Like Growth Factor 1 Receptor and Src Family Kinase YES in Rhabdomyosarcoma
Authors: Akshintala Srivandana , Sundby R. Taylor , Bernstein Donna , Glod John W. , Kaplan Rosandra N. , Yohe Marielle E. , Gross Andrea M. , Derdak Joanne , Lei Haiyan , Pan Alexander , Dombi Eva , Palacio-Yance Isabel , Herrera Kailey R. , Miettinen Markku M. , Chen Helen X. , Steinberg Seth M. , Helman Lee J. , Mascarenhas Leo , Widemann Brigitte C. , Navid Fariba , Shern Jack F. , Heske Christine M.
Published: July 2023

Adverse events possibly, probably, or definitely related to ganitumab across all 28 cycles (maximum grade per patient)
Supplementary Table S1 from Dissecting the Mechanisms Underlying the Cytokine Release Syndrome (CRS) Mediated by T-Cell Bispecific Antibodies
Authors: Leclercq-Cohen Gabrielle , Steinhoff Nathalie , Albertí Servera Llucia , Nassiri Sina , Danilin Sabrina , Piccione Emily , Yángüez Emilio , Hüsser Tamara , Herter Sylvia , Schmeing Stephan , Gerber Petra , Schwalie Petra , Sam Johannes , Briner Stefanie , Jenni Sylvia , Bianchi Roberta , Biehl Marlene , Cremasco Floriana , Apostolopoulou Katerina , Haegel Hélène , Klein Christian , Umaña Pablo , Bacac Marina
Published: July 2023

Supplementary Table S1. Specification of reagents for flow cytometry (Whole Blood Assay)
Supplementary Figure S9 from Dissecting the Mechanisms Underlying the Cytokine Release Syndrome (CRS) Mediated by T-Cell Bispecific Antibodies
Authors: Leclercq-Cohen Gabrielle , Steinhoff Nathalie , Albertí Servera Llucia , Nassiri Sina , Danilin Sabrina , Piccione Emily , Yángüez Emilio , Hüsser Tamara , Herter Sylvia , Schmeing Stephan , Gerber Petra , Schwalie Petra , Sam Johannes , Briner Stefanie , Jenni Sylvia , Bianchi Roberta , Biehl Marlene , Cremasco Floriana , Apostolopoulou Katerina , Haegel Hélène , Klein Christian , Umaña Pablo , Bacac Marina
Published: July 2023

Supplementary Figure S9. Single cell RNA-sequencing of whole blood treated with 0.2 μg/mL CD20-TCB was performed using the BD Rhapsody platform
Supplementary Figure S6 from Dissecting the Mechanisms Underlying the Cytokine Release Syndrome (CRS) Mediated by T-Cell Bispecific Antibodies
Authors: Leclercq-Cohen Gabrielle , Steinhoff Nathalie , Albertí Servera Llucia , Nassiri Sina , Danilin Sabrina , Piccione Emily , Yángüez Emilio , Hüsser Tamara , Herter Sylvia , Schmeing Stephan , Gerber Petra , Schwalie Petra , Sam Johannes , Briner Stefanie , Jenni Sylvia , Bianchi Roberta , Biehl Marlene , Cremasco Floriana , Apostolopoulou Katerina , Haegel Hélène , Klein Christian , Umaña Pablo , Bacac Marina
Published: July 2023

Supplementary Figure S6. A. Bulk-rna-sequencing of neutrophils purified from whole blood 4 hrs and 20 hrs following treatment with 0.2 μg/mL CD20-TCB or 0.2 μg/mL DP47-TCB for N=4 donors. B. Heat map showing the enriched hallmark pathways in neutrophils, 4 hrs and 20 hrs following treatment with CD20-TCB or DP47-TCB. C. Heat map showing the expression of TNF-α (TNF), IL-1β (IL1B), IL-6 (IL6), MCP-1 (CCL2), MIP-1α (CCL3), MIP-1β (CCL4) and IP-10 (CXCL10) genes in neutrophils, 4 hrs and 20 hrs following treatment with CD20-TCB or DP47-TCB (untargeted TCB). Volcano plots depicting the cytokine genes in neutrophils D. 4 hrs and E. 20 hrs after treatment with CD20-TCB. Each dot represents one gene. The x axis shows the logarithmic fold change and the y axis shows the negative log of the p value for each gene by comparing samples treated with CD20-TCB to samples treated with DP47-TCB (untargeted TCB).
Supplementary Figure S3 from Dissecting the Mechanisms Underlying the Cytokine Release Syndrome (CRS) Mediated by T-Cell Bispecific Antibodies
Authors: Leclercq-Cohen Gabrielle , Steinhoff Nathalie , Albertí Servera Llucia , Nassiri Sina , Danilin Sabrina , Piccione Emily , Yángüez Emilio , Hüsser Tamara , Herter Sylvia , Schmeing Stephan , Gerber Petra , Schwalie Petra , Sam Johannes , Briner Stefanie , Jenni Sylvia , Bianchi Roberta , Biehl Marlene , Cremasco Floriana , Apostolopoulou Katerina , Haegel Hélène , Klein Christian , Umaña Pablo , Bacac Marina
Published: July 2023

Supplementary Figure S3. Identification of an interacting B and T cells cluster by scRNA-sequencing of human whole blood treated with 0.2 μg/mL CD20-TCB using the BD Rhapsody platform.
Supplementary Figure S13 from Dissecting the Mechanisms Underlying the Cytokine Release Syndrome (CRS) Mediated by T-Cell Bispecific Antibodies
Authors: Leclercq-Cohen Gabrielle , Steinhoff Nathalie , Albertí Servera Llucia , Nassiri Sina , Danilin Sabrina , Piccione Emily , Yángüez Emilio , Hüsser Tamara , Herter Sylvia , Schmeing Stephan , Gerber Petra , Schwalie Petra , Sam Johannes , Briner Stefanie , Jenni Sylvia , Bianchi Roberta , Biehl Marlene , Cremasco Floriana , Apostolopoulou Katerina , Haegel Hélène , Klein Christian , Umaña Pablo , Bacac Marina
Published: July 2023

Supplementary Figure S13. A. 3D in vitro experimental setup. Human PBMCs and SU-DHL-8 tumor cells were co-cultured in a ratio of 5:1 and treated with 0.01 nM CD20-TCB in the presence or absence of 5 μg/mL adalimumab for 24 hrs. Supernatant from the co-cultures was transferred to the bottom channel of the Mimetas OrganoPlate®. PBMCs derived from the same donor as in the co-cultures, are fluorescently labeled and seeded in the upper channel of the Mimetas OrganoPlate®, where endothelial tubules have been previously formed. Mimetas OrganoPlate® are then imaged with the Operetta System to quantify fluorescent cell transmigration at 24 hrs. B. Shown is the cell migration towards cytokine-rich supernatants in the Mimetas OrganoPlate®. TNF-α pretreatment of the endothelial tubule is a positive control. Means of technical replicates from 2 independent experiment +/- SD with ****p<0.0001, **p<0.001 by 2 way ANOVA.
Supplementary Figure S12 from Dissecting the Mechanisms Underlying the Cytokine Release Syndrome (CRS) Mediated by T-Cell Bispecific Antibodies
Authors: Leclercq-Cohen Gabrielle , Steinhoff Nathalie , Albertí Servera Llucia , Nassiri Sina , Danilin Sabrina , Piccione Emily , Yángüez Emilio , Hüsser Tamara , Herter Sylvia , Schmeing Stephan , Gerber Petra , Schwalie Petra , Sam Johannes , Briner Stefanie , Jenni Sylvia , Bianchi Roberta , Biehl Marlene , Cremasco Floriana , Apostolopoulou Katerina , Haegel Hélène , Klein Christian , Umaña Pablo , Bacac Marina
Published: July 2023

Supplementary Figure S12. Individual tumor growth curves for each treatment group. OCI-Ly18 (DLBCL)-bearing humanized NSG mice were pre-treated with 30 mg/kg Gazyva (Gpt, grey arrow) and treated weekly with escalating doses of CD20-TCB (0.5 mg/kg, 1 mg/kg, 2 mg/kg, red arrows). Adalimumab (25 mg/kg, orange arrow, TNF-α blockade) and tocilizumab (10 mg/kg, green arrow, IL-6R blockade) were given 1 day and 1 hour before the first CD20-TCB infusion. Dexamethasone (1 mg/kg, blue arrow) was given 1 hour prior each therapy. Anakinra (10 mg/kg, purple arrow, IL-1R blockade) and the NLRP3 inhibitor (20 mg/kg, light blue arrow) were administered 1 hour before, 4 hrs and 24 hrs after the first CD20-TCB infusion as well as 1 hr before and 4 hrs after the second CD20-TCB treatment. Individual tumor growth curves for each treatment group.
The Recurrent Atypical e8a2 BCR::ABL1 Transcript with Insertion of an Inverted 55 Base Pair ABL1 Intron 1b Sequence: A Detailed Molecular Analysis
Authors: Burmeister Thomas , Bullinger Lars , le Coutre Philipp
Published: July 2023

Atypical BCR::ABL1 transcripts are found in approximately 2% of cases of chronic myeloid leukemia. It is important to detect them since affected patients also benefit from tyrosine kinase inhibitor therapy. In the rare e8a2 atypical BCR::ABL1 transcript, two out-of-frame exons are fused, thus, interposed nucleotides are usually found at the fusion site to restore the reading frame. In approximately half of previously reported e8a2 BCR::ABL1 cases, an inserted 55 bp sequence homologous to an inverted sequence from ABL1 intron 1b was detected. The generation of this recurrent transcript variant is not obvious. This work describes the molecular analysis of such an e8a2 BCR::ABL1 translocation from a CML patient. The genomic chromosomal breakpoint is identified, and the formation of this transcript is theoretically explained. The clinical course of the patient is reported, and recommendations are provided for the molecular analysis of future e8a2 BCR::ABL1 cases.
Fukuzawa, Liberalism, and the Imperial Temptation
Authors: Hiruta Kei
Published: July 2023

This review essay juxtaposes Fukuzawa Yukichi’s Bourgeois Liberalism by Minhyuk Hwang with Progress, Pluralism, and Politics by David Williams, both published in 2020. Although the two books are motivated by different concerns and are likely to attract different audiences, I show that they can be read together to throw light on the complicated relationship between liberalism and empire from a comparative angle. On the one hand, I draw on Williams’s book and other recent works in the history of political thought to criticize some aspects of Hwang’s discussion of Fukuzawa. On the other hand, I draw on Hwang’s book and other studies on Fukuzawa to tease out the implications of Williams’s book for an important issue that has been marginalized in the recent Anglophone scholarship on liberalism and empire: the imperial temptation for non-Western liberals.
Parental drinking, mental health and educational level, and offspring’s subsequent prescription drugs treatment for sleep problems. A longitudinal HUNT survey and registry study
Authors: Lund Ingunn Olea , Andersen Njål , Ask Helga , Andreas Jasmina Burdzovic
Published: July 2023

Background

Parental drinking, mental health and family socioeconomic status are all associated with offspring sleep problems, but there is a paucity of research that considers the effect of risk factors, as they co-occur within and across families. Also, sleep problems are closely linked with mental health problems. Disentangling the effects on one or the other are important. We examined whether parental risk constellations are differently associated with offspring’s subsequent prescription drug use for sleep problems during nine years with or without prescription drug use for anxiety and/or depression.

Methods

The sample included 8773 adolescent offspring of 6696 two-parent families who participated in the Nord-Trøndelag Health Study in Norway. The exposures were five parental risk constellations, previously identified via Latent Profile Analysis, characterized by drinking frequencies and quantities, mental health, and years of education. The outcomes were dispensed prescription drugs in offspring during 2008–2016 for (a) only sleep problems (b) sleep problems and anxiety/depression or (c) only anxiety/depression. We used multinomial logistic regression to model the odds of the outcomes.

Results

Compared to the overall low-risk parental constellation, none of the risky constellations were significantly associated with increased risk of being dispensed prescription drugs only for sleep problems. Offspring from two different risk profiles were at increased risk for being dispensed both sleep and anxiety/depression prescription drugs. These were parental profiles marked by (1) low education, symptoms of mental health problems and weekly binge drinking in both parents (OR 1.90, CI = 1.06;3.42); and (2) frequent heavy drinking in both parents and symptoms of mental health problems in fathers (OR 3.32, CI = 1.49;7.39). Offspring from the risk profile with lowest parental education had increased risk of only anxiety/depression prescription drugs (OR 1.25, CI = 1.05;1.49).

Conclusion

Our findings suggest that parental risk constellations are not associated with increased risk of offspring receiving sleep medications without also receiving anxiety/depression medications, as two risk constellations were associated with increased risk of dispensation of both sleep and anxiety/depression prescription drugs. Receiving both may be an indication of severity. The findings underscore the importance of including measures of mental health problems when investigating sleep problems to avoid misattribution of effects.
Weaning – Research into mothers' experiences of the first four weeks
Authors: Hewison Ruth
Published: July 2023

In the first article in this series, Ruth Hewison, Early Childhood Studies graduate, writes about her undergraduate research project into mothers' experiences of the first four weeks of weaning. It concentrates on investigating and evaluating the academic literature about weaning to create a base of knowledge and gives a brief introduction into her research methodology.
A classification of the prime graphs of pseudo-solvable groups
Authors: Huang Ziyu , Keller Thomas Michael , Kissinger Shane , Plotnick Wen , Roma Maya , Yang Yong
Published: July 2023

The prime graph

Γ
⁢

(
G
)

\Gamma(G)

of a finite group 𝐺 (also known as the Gruenberg–Kegel graph) has as its vertices the prime divisors of

|
G
|

\lvert G\rvert

, and

p
⁢
-
⁢
q

p\textup{-}q

is an edge in

Γ
⁢

(
G
)

\Gamma(G)

if and only if 𝐺 has an element of order

p
⁢
q

pq

.
Since their inception in the 1970s, these graphs have been studied extensively; however, completely classifying the possible prime graphs for larger families of groups remains a difficult problem.
For solvable groups, such a classification was found in 2015.
In this paper, we go beyond solvable groups for the first time and characterize the prime graphs of a more general class of groups we call pseudo-solvable.
These are groups whose composition factors are either cyclic or isomorphic to

A
5

A_{5}

.
The classification is based on two conditions: the vertices

{
2
,
3
,
5
}

\{2,3,5\}

form a triangle in

Γ
̄

⁢

(
G
)

\overline{\Gamma}(G)

or

{
p
,
3
,
5
}

\{p,3,5\}

form a triangle for some prime

p
≠
2

p\neq 2

.
The ideas developed in this paper also lay the groundwork for future work on classifying and analyzing prime graphs of more general classes of finite groups.
Estudios de caso de la política exterior española hacia el Mundo Árabe y Musulmán: Líbano
Authors: Sánchez Mateos Elvira
Published: July 2023

Este texto analiza la política exterior española hacia Líbano a partir de los datos que aporta la “Base de Datos sobre Política Exterior” (BDPEX), un nuevo instrumento que arroja nueva luz sobre el estudio de las relaciones exteriores españolas. De los datos se desprende que Líbano es un país secundario para los intereses españoles, y que su importancia, en los últimos años, deriva del interés español en el proceso de paz de Oriente Medio y de la participación española, a partir de 2006, en la Fuerza Provisional de las Naciones Unidas en Líbano (FPNUL).  Así lo demuestra el análisis de los datos sobre intercambio de visitas de alto nivel, debate parlamentario, aportación española a la cooperación en Líbano e intercambios económicos.AbstractThis paper analyzes the Spanish foreign policy towards Lebanon from the data provided by the "Database on Foreign Policy" (BDPEX), a new instrument which shed new light on the study of Spanish foreign relations. The data show that Lebanon is a secondary country for Spanish interests, and that its importance in recent years derives from the Spanish interest in the Middle East Peace Process and Spanish participation, from 2006 on, in the United Nations Interim Force in Lebanon (UNIFIL). This is demonstrated by the analysis of data on exchange of high level visits, parliamentary debates, Spanish contribution to cooperation in Lebanon and economic exchanges.
La cooperación al desarrollo de España en Marruecos
Authors: Mañé Estrada Aurelia , Fernández Molina Irene
Published: July 2023

La cooperación al desarrollo de España en Marruecos constituye una herramienta fundamental en la construcción de la interdependencia entre estos dos países.
Theoretical method for prediction of the cutting edge recession during milling wood and secondary wood products
Authors: Porankiewicz Bolesław
Published: July 2023

A theoretical method for prediction of cutting edge recession during milling wood and wood-based products, due to the presence of hard mineral contamination, High Temperature Tribochemical Reactions (HTTR), and frictional wearing, based on 3D random distribution of contaminant particles is presented and positively verified based on the example of three experiments from the literature, showing good correlation between the predicted and observed cutting edge recession.
“And he wept over Jerusalem”: On possible sources of Francysk Skaryna’s engraving of prophet Jeremiah in Bivlia Ruska
Authors: Shutova Olga
Published: July 2023

The article discusses the possibilities of understanding the woodcuts of Francysk Skaryna’s Bivlia ruska from the perspective of the intellectual ‘cosmos’ in the Renaissance Europe. We shall focus on the engraving “Jeremiah the prophet of the Lord weeps while looking at Jerusalem” (árámia púrr¼k7 g³dán6 pla+át6 glád3 na árusali, Скорина Ф. Книжка рекомая плачь Еремиинъ, hereinafter: The Book of Lamentations) putting it in the context of the iconography of this biblical character in the Renaissance. The article warns against ‘inscribing’ Skaryna’s image of Jeremiah in already-prepared schemes. Leaving open the solution of the possible visual sources of Skaryna’s engravings, we would like to avoid its traditional reading, based mainly on classifications, too often subjective and artificial. Our reading of Jeremiah is based on the study of his visual representations widespread in the Renaissance Europe in the late 15th and the early 16th centuries (Albrecht Dürer’s woodcut St. Anthony Reading from 1519; Hartmann Schedel’s Liber Chronicarum, 1493; Biblia vulgare istoriata, 1490, translated by N. Malermi; Biblij Czěská, w Benatkach tisstěná, 1506; Bernard von Breydenbach’s Sanctae peregrinationes, 1486; Werner Rolewinck’s Fasciculus temporum omnes antiquorum cronicas complectens, 1473/74 and its Venetian reprints by E. Ratdolf in the 1480s, etc.). The article emphasizes the importance to frame this iconography in the philosophical and aesthetical contexts of Francysk Skaryna’s epoch (by appealing to such sources as Dürer’s diaries, the works of Marsilio Ficino, quotations of F. Skaryna himself, etc.). We shall examine the plot, the characteristic features of Jerusalem landscape, architecture, religious symbols, and clothes represented at Jeremiah’s engraving in Bivlia ruska to seek the possible sources and inspirations of this engraving, while emphasizing its original character.
KILAS BALIK EKONOMI ISLAM DI INDONESIA
Authors: Musfiqoh Siti
Published: July 2023

The historical development of Islamic system economic  in Indonesia reflects the dynamics of the aspirations and wishes of the Indonesian people themselves, to have an alternative fair economic system, in the real sector. as an alternative search process in the monetary system which is characterized by the principles of transparency, fairness, balance and ethics in creating a prosperous society materially and spiritually. The initial of  this alternative search system, initiated by scientific studies about Islamic economic and financial. The result of those studies is the publication of islamic banking laws. The initial of Islamic economic system of banking began in the early 1980's, when the government issued a policy package on Banking liberalization.The scholars' at that time established an interest-free rate, bank Muamalat (Islamic banks) at the end of 1991 and operational in early 1992, but none of the legal device that can be used as a reference.This condition lasted until the year 1997, in which Indonesia was hit by the economic and moneter crisis.At that time, when conventional banks had been liquidated, , Islamic banks showed their existence and do not experience economic shocks.
Aspiration of Indonesian people had been growing to have an Islamic financial institutions, non bank financial institutions and the banking through the application of system for a favorable outcome for the customer and the bank. Furthermore, the trial conducted by the public along with academics and practitioners to realize and practice the idea of monetary systems ranging from small-scale enterprises both bank and non bank financing are trying to apply the concept of revenue sharing.
At this stage, the establishment of Islamic banks are seen as an indicator of economic progress is happening in Islamic economic, so almost society equate Islamic Economic with Islamic banks, or non-bank sharia financial institutions other.
Though the scope of Islamic economics is much broader than just a Sharia finance. It covers macroeconomic concepts, micro-economic, fiscal, monetary, and also the much concept of economic development policies and instruments with all the variables.
PASAR MODAL SYARIAH DI INDONESIA
Authors: Fauzia Ika Yunia
Published: July 2023

The Birth of shariah capital market in Indonesia is a breakthrough, in order to open a new niche on the trading floor. With distinct segmentation, it is expected that local Moslem investors and Middle Eastern investors will be colouring investment growth in it. The existance of sharia capital markets, will also participate in enhancing the development and the growth of national economic because it can strengthen industries and companies financial position. In which industries and companies engaged in efforts dealing with shariah,  which can provide a positive contribution to peopleâ€™s live.  However modern economy will rely heavily on strong capital markets, global competitivenes and also good system. And it is expected that sharia capital market in Indonesia could have strong competitivenes so that can develop, deliver profit and benefit for the community of investors, industry sectors and society in general.
KEBIJAKAN FISKAL DAN IMPLIKASINYA TERHADAP PEMBANGUNAN EKONOMI
Authors: Mansur Ahmad
Published: July 2023

Fiscal policy beside monetary policy is usually used by the government to overcome the macro economic problems regarding stabilization in the short-run such as control of inflation to make it low inflation, alleviating poverty, achieving full employment and control of balance of payment to make it in balance or even surplus and in the long-run achieving economic growth, prosperity and sustainable economic development. This research tries to investigate the role of fiscal policy and its implication on economic development in an Islamic perspective conceptually and theoretically. It found that the instrument of fiscal policy in an Islamic perspective not only using tax and government expenditure but also zakah which could be utilized to counter cyclical fiscal policy.
Zakah as one of the instrument of fiscal policy could also be utilized to achieve equitable distribution of income and wealth as the basic characteristic of zakah is redistribution of wealth taken from the rich and given to the poor ones. In the time of stagflation, zakah instrument could become powerful tool to overcome that problem through demand side and thus stimulate production. Although this mechanism is not as simple as we perceived, zakah does help overcome the macroeconomic problems on conditions that we also adopt and implement Islamic values and Islamic norms in our economy.
PENGELOMPOKAN KABUPATEN/KOTA DI JAWA TIMUR BERDASARKAN VARIABEL-VARIABEL INDEKS PEMBANGUNAN MANUSIA
Authors: Wulansari Andita Desy
Published: July 2023

Human Development Index (HDI) is a composite indicator (combined), which is linked to several variables. This indicator can be beneficial if done properly use the comparison across time and across regions, so that the relative position of a region to another region can be determined as well as the progress and achievement comparison with other areas may also be covered. In general, indicators are useful as an advocacy tool for formulators and decision makers in each region, particularly with regard to public policy is selected and set. Utilization HDI indicators can be used more widely, especially in the context of regional autonomy emphasis on districts / cities, where most of the powers, functions and duties have been transferred to local government autonomy. Thus monitoring the development of self-government performance can be evaluated. East Java is a province with a number of districts / cities most in Java, consists of 29 counties and 9 cities. Respective districts / cities in East Java has the characteristics of the population, condition of the area and can not be equated wisdom for all areas depending on their individual requirements. Can also informed that, based on the 2008 national HDI ranking of East Java Province was ranked 18 out of 33 provinces in Indonesia. When compared to the HDI provinces in Java, East Java Province just better than Banten province who is ranked 23. In order to help resolve issues relating to equitable development in the health sector, education and the economy, it is necessary information about the grouping of districts / cities in East Java Province. In this study, the grouping of districts / cities in East Java is done by principal component analysis and cluster analysis to the non hierarchical / K-Means. With a non-hierarchical grouping the regions that have similar properties to form a single group. Grouping districts / cities in East Java based IPM variables divided into 2 groups: the high-potential areas in group 1 and low potential areas in group 2. Based on the analysis of data obtained in the regions of the incoming group 1 there were 24 districts/cities and 13 districts/cities rest went in groups of 2.