bluuebunny/crossref_metadata_2025 huggingface dataset:
SCENARIOS FOR THE DEVELOPMENT OF POLITICAL POWER IN YEMEN IN THE CONTEXT OF THE ONGOING CONFLICT
Authors:   Tambov State Technical University, Tambov, Russian Federation, PENKOV V.F. , ALDAKHERI A.A.A. , ALARUSI Z.M.M. ,   Ural Humanitarian Institute of the Ural Federal University named after the First President of Russia B.N. Yeltsin, Yekaterinburg, Russian Federation
Published: October 2023

The article discusses issues related to the forecasts of the development of political power in Yemen, taking into account the impact of the ongoing conflict on the territory of the state. In current events, Yemen is a country characterized by high uncertainty about the further development of events in the field of political structure and ensuring the legitimacy of the government. The above-mentioned aspects determine a wide range of approaches and opinions related to the further political structure of Yemen. This article presents an attempt to generalize existing approaches and highlight key scenarios for the development of political power in Yemen.
ELEKTRONİK PAZARYERİ İŞLETMECİLERİNİN SATICILAR BAKIMINDAN YAPMIŞ OLDUĞU ARACILIK FAALİYETİNİN HUKUKÎ NİTELİĞİ
Authors: BİNGÖL Muhammet Emin
Published: October 2023

Bu çalışmada, elektronik pazaryerinde ürünlerini sergileyerek “satış” yapan kişiler için söz konusu pazaryerini elektronik ortamda sağlayan pazaryeri işletmecisinin yapmış olduğu faaliyetin hukukî niteliği ile elektronik pazaryeri işletmecisinin niteliği çerçevesinde ilgili sözleşme tipi için kanunda öngörülen hükümlerin bazılarının taraflar arasındaki ilişkiye uygunluğu değerlendirilmiştir. Bu anlamda pazaryeri işletmecisinin pazaryeri sözleşmesi ile üstlendiği faaliyetin en temelde aracılık; pazaryeri işletmecisinin kendisinin de aracı olduğu kanaatine varılmıştır. Yine kural olarak sürekli olarak bir ticari işletme için aracılık yapan pazaryeri işletmecisinin yapmış olduğu aracılık faaliyetinin acentelik olarak nitelendirilmesi gerektiği sonucuna ulaşılmıştır. Pazaryeri sözleşmesinde pazaryeri işletmecisinin birtakım asli başka edimleri üstlenmiş olması sebebiyle pazaryeri sözleşmesinin farklı şekillerde nitelendirildiği hâllerde pazaryeri sözleşmesinin karakteristik ediminin aracılık faaliyeti olması TTK’da düzenlenen acentelik hükümlerinin uygulama alanı bulabileceği mütalaa edilmiştir.
HINÇ, ADALET VE HINÇ ADALETİ: ELEŞTİREL BİR DEĞERLENDİRME
Authors: TÜRK Rıdvan
Published: October 2023

Rabia Sağlam’ın Hınç Adaleti ve Affetme başlıklı kitabında geliştirdiği hınç adaleti kuramı, hukuk düzeninin yozlaştığı ve adaleti gerçekleştirme işlevini kaybettiği bir toplumda, hınçlı mağdurların faillerden haklarını kendi elleriyle alabileceklerini öngörmektedir. Yazara göre hınç öznesinin intikamının meşruiyeti, mağdurun sosyoekonomik eşitsizliğin dezavantajlı tarafında bulunmasına ve adaletin güçlü failler tarafından yolundan saptırılması şartına bağlıdır. Sosyoekonomik açıdan avantajlı faillerin işlediği suçlar veya verdiği zararlar, şayet hukuk failleri koruyor ya da bu failler güçleri sayesinde hukukun yargısından kaçabiliyorsa, hınç adaletinin konusunu oluşturur. Sağlam’a göre, bu koşullar gerçekleştiğinde, hakkı verilmeyen hınçlı mağdurların haklarını kendilerinin alması hem ahlâken hem hukuken meşru kabul edilmelidir. Bu çalışmada kurama yönelik iki eleştiri sunuluyor. İlk eleştiride, hınç adaletinin hınç psikolojisinden bir adalet düşüncesine ulaşırken ortaya çıkabilecek felsefi zorlukları yeterince irdelemediği iddia ediliyor. Bu çerçevede hınçla dolu mağdurun her türlü intikam ediminin meşru olup olmadığı, hınç adaletinin şiddetinin bir sınırının bulunup bulunmadığı gibi sorular gündeme getiriliyor. İkinci eleştiride ise, sosyoekonomik eşitsizlik ve hukuki yozlaşma koşullarının hukuk dışı tekil bir şiddet ediminin ahlâki ve hukuki meşruiyeti için yeterli veya uygun olmadığı; gölgede kalan bazı hususlarının aydınlatılması ve tartışmanın bu doğrultuda genişletilmesi gerektiği öne sürülüyor.
HUKUK VE DEĞİŞKEN DOĞRULUK: TOULMIN İZİNDE BİR İNCELEME
Authors: KARACA Meriç Seyhan
Published: October 2023

Hukukî akıl yürütme hukukun her aşamasında içkindir ve her akıl yürütme gibi doğru değerlendirmeyi amaçlar. Hukukta doğruluk meşruluk, hukuka uygunluk veya haklılık olarak karşımıza çıkabilir. Meşruluk da hukuka uygunluk da haklılık da gerekçelerle gösterilir. Argümantasyon, fiilî veya potansiyel fikir çatışmaları ile yürüyen, fiilî veya potansiyel muhatabı gerekçelerle ikna etmeyi amaçlayan bir süreçtir. Dolayısıyla hukukun özel bir tür argümantasyon faaliyeti olduğu söylenebilir. Sağlam argümantasyonun koşul ve gerekleri bulunduğumuz konuma göre değişecektir. Bu çalışmada Stephen E. Toulmin’in argümantasyon teorisi, felsefî arka planı ile birlikte ortaya konmaya çalışılacaktır. Yazar pratik akıl yürütmelerin değerlendirilmesinde şeklî mantığın yetersiz olduğunu düşünür ve argümantasyonu “informel/şeklî olmayan” mantık olarak görür. Ona göre bir argümanın gücü hem geçerli hem de sağlam olmasından gelir. Toulmin’in düşüncesi, argümantasyonun ve hukukî argümanların değerlendirilmesi için kullanışlı bir çerçeve sağlar. Çalışmanın amacı bu çerçevede hukuk kavramını ve hukukî akıl yürütmeyi yeniden değerlendirmek ve argümantasyon ile hukuk, argümantasyon teorisi ile hukuk teorisi arasındaki değiş-tokuşa işaret etmektir.
Where the truth lies: a paraconsistent approach to Bayesian epistemology
Authors: Carnielli Walter , Bueno-SOler Juliana
Published: October 2023

Bayesian epistemology has close connections to inductive reasoning, accepting the view that inductive inferences should be analyzed in terms of epistemic probabilities. An important precept of Bayesian epistemology is the dynamics of belief change, with change in belief resulting from updating procedures based on new evidence. The inductive relations between evidence E and hypotheses or theories H are essential, particularly the notions of plausibility, confirmation, and acceptability, which are critical but subject to several difficulties. As a non-deductive process, Bayesian reasoning cannot itself be subjected to strict deductive logic, but it can take advantage of an enabling logical environment. The present paper proposes that paraconsistent and paracomplete logics can be helpful for some questions of Bayesian epistemology, even to the point of being relevant in developing a legitimate paraconsistent Bayesian epistemology. By developing a novel probability theory based on the Logic of Evidence and Truth (LETF ), a logic that deals with evidence for or against a judgment, including contradictory or missing evidence, we allow for the possibility of quantifying the degree of evidence attributed to a proposition through novel probability measures. We illustrate, through examples, some ways to address challenging problems in the area by using paraconsistent and paracomplete paradigms. This topic is of significant interest not only in the philosophy of science but also in Artificial Intelligence and other emerging trends such as probabilistic networks and related models.
Unveiling the Mask: Navigating the Depths of Black Men’s Mental Health
Authors: Robinson Tay D.
Published: October 2023

The objective of this article is to address the existing informational gap about the mental health of Black males. This article examines the phenomenon of intergenerational trauma among Black males, explores the historical events that have contributed to the emergence of hurdles faced by this demographic, and sheds light on the prevailing mental health diagnoses widespread within the Black male population. By consistently restating the established facts presented in this article and providing potential solutions, it is anticipated that this will attract the interest of mental health experts, educators in the field of social work, and policymakers. By fostering collaboration among academics, practitioners, and educators, a collective effort may be made to enhance our understanding of the mental health of Black males and identify strategies to effectively address their specific needs.
An Investigation of Some Difficulties in Idioms Encountered by Saudi Learners of English
Authors: Noor Hashim
Published: October 2023

The present study investigated the ability of Saudi English major female students to recognize and comprehend English idioms in certain contexts. Subjects were 60 senior Saudi female learners of English, Taibah University. Their recognition and comprehension of English pure idioms were tested with translation and multiple-choice tests. The results demonstrate that context plays an essential role in facilitating the processes of recognizing and comprehending English idioms effectively. Idioms that were more easily recognized and comprehended were those which were frequently used, transparent and which had simple vocabulary and structure..
Book Review of Abdullah Dabbagh's Literary Orientalism, Postcolonialism, and Universalism
Authors: Khalil Hamdi Tahrir
Published: October 2023

Book Review of Abdullah Dabbagh's Literary Orientalism, Postcolonialism, and Universalism.
Islam’s Narrative in American Literature
Authors: J. McDonald John
Published: October 2023

This paper examines representations of Islam and the Near East in works of American writers from the 17th- 21st centuries. It argues that American cultural views of Islam and “the East,” are constructed upon fear of the “other,” a desire to dominate, and popular yet uninformed ideas about Islam and Muslim peoples.

Tobias Wolff’s (2008) short story titled “White Bible” centers on Maureen Casey, who teaches at a Catholic high school in upstate NY. Maureen does not derive any satisfaction from her work as a teacher, and after drinking at a bar one evening after work she is abducted in the parking lot by the father of her student Hassan. Thinking she is the victim of a car-jacking, Maureen offers her abductor money. He refuses.

“Please,” she said. “What do you want?” (292).

Abu Hassan answers,

“This is not about sex…That is what you are thinking, of course. That is the American answer to everything” (ibid.). .
ANALISIS KONFLIK RELOKASI KAMPUNG BUKIT DURI MENGGUNAKAN PENAHAPAN KONFLIK DAN BAWANG BOMBAY
Authors: Setiyani Wiji
Published: October 2023

Relokasi Kampung Bukit Duri menimbulkan konflik karena masyarakat keberatan dengan perintah penggusuran. Penggusuran terjadi pada 28 September 2016 atas perintah Pemerintah Provinsi DKI Jakarta. Proses relokasi diwarnai dengan bentrokan karena perlawanan masyarakat yang kuat dan penggunaan otoritas dalam proses relokasi, serta Pemerintah menggunakan kekuasaannya untuk melakukan penggusuran tanpa mempedulikan masyarakat Kampung Bukit Duri. Relokasi Kampung Bukit Duri menjadi salah satu polemik utama dari berbagai relokasi yang terjadi selama 2015-2016. Tujuan dari penelitian ini mengetahui analisis konflik dengan menggunakan alat penahapan konflik dan analogi bawang bombay, serta mengetahui strategi mengelola konflik multitingkat dan roda. Penelitian ini menggunakan studi literatur untuk melihat analisis konflik Kampung Bukit Duri. Hasil penelitian diperoleh konflik terjadi karena program dari pemerintah memiliki maksud tujuan yang baik untuk menata ulang kota tetapi dalam implementasikan tidak memperhatikan terkait hak-hak yang seharusnya didapatkan oleh masyarakat, walaupun pada tahun 2021 Pemerintah Provinsi DKI Jakarta telah meresmikan Kampung Susun Produktif Tumbuh Cakung, tetapi dikhawatirkan akan menimbulkan pra konflik karena masyarakat yang tidak dapat membayar harga sewa. Rekomendasi penelitian ini diharapkan akan memudahkan masyarakat memahami konflik yang terjadi di Kampung Bukit Duri dengan adanya kebijakan yang dikeluarkan oleh pemerintah terkait relokasi dan memahami strategi dalam mengelola konflik yang terjadi di Kampung Bukit Duri.
Diplomasi publik Jepang terhadap Indonesia menggunakan budaya populer
Authors: Vania Calista Farahdiba Rizki , Anggoro Catur Wisnu
Published: October 2023

Di era globalisasi yang serba mudah, diplomasi tradisional yang hanya mengandalkan perwakilan nasional untuk diplomasi tidak terlalu efektif, terutama dalam hal country branding dan diseminasi budaya, yang merupakan aset penting dalam membangun kekuatan nasional. Setelah Perang Dunia II, Jepang menggunakan diplomasi publik dalam menjalankan hubungan luar negerinya. Diplomasi publik secara umum dapat didefinisikan sebagai cara suatu negara mempengaruhi negara lain melalui aktor selain negara. Hal ini dilakukan untuk mendapatkan pandangan yang lebih baik dari suatu negara. Inilah yang dilakukan Jepang kepada Indonesia dalam menyebarkan diplomasi publiknya dengan menggunakan budaya populer Jepang. Upaya melaksanakan diplomasi publik dapat dilihat melalui penyebaran budaya masyarakat tokusatsu series, anime, manga, majalah, dan produk lainnya serta franchise yang ada terkenal di berbagai negara. Diplomasi budaya merupakan upaya yang dilakukan oleh suatu negara untuk menyebarkan pengaruhnya melalui kebudayaannya sumber dan situs yang dikenal luas oleh masyarakat internasional, keunikan budaya suatu negara nantinya akan digunakan oleh negara tersebut sebagai alat untuk mempengaruhi atau menyebarkan pengaruhnya kepada negara-negara lain.
Indonesia-China Cooperation For The Development And Improvement of Digital Technology 4.0 in The Field of Security And Economy
Authors: Arianto Adirio , Maarif Dairatul , Muhadjir M , Argaditya Raynor
Published: October 2023

Kerjasama industri 4.0 antara Indonesia-China di sektor keamanan dan ekonomi digital merupakan suatu hal yang penting bagi kedua negara. China memiliki jumlah pengguna internet terbesar di dunia, dilanjutkan dengan Indonesia yang berada di peringkat kelima. Bagi Indonesia, kerjasama ini dipandang mampu mengakselerasi pembangunan infrastruktur digital disektor keamanan dan ekonomi. Sedangkan bagi China, kerjasama ini dipandang mampu membuka peluang sekaligus memperluas pasar ekonomi teknologi digitalnya di luar negeri. Penelitian ini berusaha untuk mengelaborasi kerjasama antara Indonesia-China dalam upaya pengembangan industri teknologi digital 4.0 di sektor keamanan dan ekonomi digital. Adapun metode yang penulis gunakan adalah metode kualitatif dengan kerangka teori kerjasama bilateral. Penelitian ini menemukan hasil bahwasannya kerjasama yang dilakukan kedua belah pihak telah memberikan dampak positif terutama dalam upaya pengembangan dan peningkatan industri 4.0 baik di sektor keamanan maupun ekonomi digital.Katakunci: Industri 4.0, Ekonomi digital, Keamanan, Kerjasama bilateral
China’s Investment in the East Coast Railway Line (ECRL) Project in Malaysia as a Strategisation of Space
Authors: Saraswati Dini Putri , Nasrum Arnaldi
Published: October 2023

The rise of China’s power has led the country to fulfil more energy supply to sustain its industrial development. However, the Straits of Malacca challenges disturbed China’s interest to transport oil from the Middle East. Hence, China chooses the BRI project to maintain the problem. This paper will try to examine China’s strategy of constructing an ECRL project in Malaysia as one of the BRI projects to be an alternative to fulfil its energy supply. This qualitative research will employ the concept of power and connectivity. The use of the ECRL Project to Strategise Chinese Interest in energy supply will also be explained to answer the research questions.
Audiovisual
Authors: Amorim Humberto , Dias Ricardo , De Almeida Ribeiro Felipe , Poletto Fabio Guilherme
Published: October 2023

Nos últimos anos, o violão vem progressivamente ganhando espaço qualitativo e quantitativo em pesquisas e publicações científicas da área musical. No Brasil, de modo especial, este crescimento tem encontrado ressonância em uma plêiade de pesquisadores(as) que pautam o instrumento em suas mais diversas abordagens. Coadunando-se a este movimento, a Revista Vórtex lança o Dossiê “Homenagem a Sérgio Abreu: violão, contextos, práticas e personagens”, encorajando a submissão de trabalhos que estejam relacionados direta ou indiretamente às atuações do homenageado como músico, transcritor ou luthier, tanto no que tange às suas relações com personagens, práticas e/ou contextos socioculturais mais amplos quanto na abordagem analítica de seus trabalhos solo, camerísticos, estilísticos, criativos e/ou de construção. Editores: Humberto Amorim, Ricardo Dias (convidados), Felipe de Almeida Ribeiro, Fabio Poletto (editores-chefes).
Regenerative potential of mesenchymal stromal cells in wound healing: unveiling the influence of normoxic and hypoxic environments
Authors: Mahjoor Mohamad , Fakouri Arshia , Farokhi Simin , Nazari Hojjatollah , Afkhami Hamed , Heidari Fatemeh
Published: October 2023

The innate and adaptive immune systems rely on the skin for various purposes, serving as the primary defense against harmful environmental elements. However, skin lesions may lead to undesirable consequences such as scarring, accelerated skin aging, functional impairment, and psychological effects over time. The rising popularity of mesenchymal stromal cells (MSCs) for skin wound treatment is due to their potential as a promising therapeutic option. MSCs offer advantages in terms of differentiation capacity, accessibility, low immunogenicity, and their central role in natural wound-healing processes. To accelerate the healing process, MSCs promote cell migration, angiogenesis, epithelialization, and granulation tissue development. Oxygen plays a critical role in the formation and expansion of mammalian cells. The term “normoxia” refers to the usual oxygen levels, defined at 20.21 percent oxygen (160 mm of mercury), while “hypoxia” denotes oxygen levels of 2.91 percent or less. Notably, the ambient O2 content (20%) in the lab significantly differs from the 2%–9% O2 concentration in their natural habitat. Oxygen regulation of hypoxia-inducible factor-1 (HIF-1) mediated expression of multiple genes plays a crucial role in sustaining stem cell destiny concerning proliferation and differentiation. This study aims to elucidate the impact of normoxia and hypoxia on MSC biology and draw comparisons between the two. The findings suggest that expanding MSC-based regenerative treatments in a hypoxic environment can enhance their growth kinetics, genetic stability, and expression of chemokine receptors, ultimately increasing their effectiveness.
Case report: Amplatzer septal occluder device migration into the descending thoracic aortic isthmus: percutaneous retrieval and redeployment
Authors: Xiang Kun , Ai Qi , He Lin , Fan Chengming
Published: October 2023

Percutaneous closure has emerged as the standard treatment for secundum-type atrial septal defects (ASDs). However, there is a rare but serious complication of occluder device migration and embolization to the heart chambers or distal vasculature during or shortly after implantation. Although this occurrence is extremely rare, it can have disastrous consequences. Fortunately, advancements in equipment and technology have facilitated the transition from surgical procedures to percutaneous techniques for removing embolized occluder devices. In this report, we present a case in which an Amplatzer septal occluder (ASO) device embolized to the descending thoracic aortic isthmus two days after implantation. The device was successfully retrieved using a percutaneous technique, and another ASO device was subsequently redeployed to the ASD. Regrettably, the patient experienced an intraoperative cardiac arrest. Despite prompt rescue efforts and recovery of vital signs, the patient still suffered postoperative sequelae. The main reason for occluder device migration in this case may have been the undersizing of the ASO device due to the operator's lack of caution.
How has teaching effectiveness been conceptualized? Questioning the consistency between definition and measure
Authors: Taylor Samantha , Thion Stéphane
Published: October 2023

Teaching effectiveness (TE) research impacts educators and their careers, learners and the quality of education they receive, and administrators and the organizations they safeguard. However, there is a lack of consistency in how TE has been conceptualized: many papers used inaccurate or implied definitions of TE, or despite discussing and often measuring TE, did not define TE—other papers defined TE without proposed measures or provided measures of the concept without defining it. We found two dimensions of TE, student-focused (outcome) and educator-focused (input), and an existing TE definition evaluated as the strongest for both dimensions. Further, TE measurements may be summarized in five categories: student evaluation of teaching effectiveness (SETE), objective measures, peer review, administrative evaluation, and self-reflection. To conceptualize TE, our findings suggest pairing the TE student-focused construct with SETE and objective measures, while the educator-focused dimensions of TE should be measured with peer review, self-assessment, and administrator evaluation. By consistently conceptualizing TE, researchers may contribute to rigorous research and work together to consistently add to the body of knowledge, thus furthering the quality of TE research.
Identification of optimal feature genes in patients with thyroid associated ophthalmopathy and their relationship with immune infiltration: a bioinformatics analysis
Authors: Xiong Chao , Wang Yaohua , Li Yue , Yu Jinhai , Wu Sha , Wu Lili , Zhang Boyuan , Chen Yunxiu , Gan Puying , Liao Hongfei
Published: October 2023

Background

Thyroid associated ophthalmopathy (TAO) is an organ-specific autoimmune disease that has a significant impact on individuals and society. The etiology of TAO is complicated and poorly understood. Thus, the goal of this study was to use bioinformatics to look into the pathogenesis of TAO and to identify the optimum feature genes (OFGs) and immune infiltration patterns of TAO.

Methods

Firstly, the GSE58331 microarray data set was utilized to find 366 differentially expressed genes (DEGs). To find important modular genes, the dataset was evaluated using weighted gene coexpression network analysis (WGCNA). Then, the overlap genes of major module genes and DEGs were further assessed by applying three machine learning techniques to find the OFGs. The CIBERSORT approach was utilized to examine immune cell infiltration in normal and TAO samples, as well as the link between optimum characteristic genes and immune cells. Finally, the related pathways of the OFGs were predicted using single gene set enrichment analysis (ssGSEA).

Results

KLB, TBC1D2B, LINC01140, SGCG, TMEM37, and LINC01697 were the six best feature genes that were employed to create a nomogram with high predictive performance. The immune cell infiltration investigation revealed that the development of TAO may include memory B cells, T cell follicular helper cells, resting NK cells, macrophages of type M0, macrophages of type M1, resting dendritic cells, active mast cells, and neutrophils. In addition, ssGSEA results found that these characteristic genes were closely associated with lipid metabolism pathways.

Conclusion

In this research, we found that KLB, TBC1D2B, LINC01140, SGCG, TMEM37, and LINC01697 are intimately associated with the development and progression of TAO, as well as with lipid metabolism pathways.
Research on carbon emission prediction and economic policy based on TCN-LSTM combined with attention mechanism
Authors: Wei Xiaoyan , Xu Ying
Published: October 2023

Introduction

In the face of increasingly severe global climate change and environmental challenges, reducing carbon emissions has become a key global priority. Deep learning, as a powerful artificial intelligence technology, has demonstrated significant capabilities in time series analysis and pattern recognition, opening up new avenues for carbon emission prediction and policy development.

Methods

In this study, we carefully collected and pre-processed four datasets to ensure the reliability and consistency of the data. Our proposed TCN-LSTM combination architecture effectively leverages the parallel computing capabilities of TCN and the memory capacity of LSTM, more efficiently capturing long-term dependencies in time series data. Furthermore, the introduction of an attention mechanism allows us to weigh important factors in historical data, thereby improving the accuracy and robustness of predictions.

Results

Our research findings provide novel insights and methods for advancing carbon emission prediction. Additionally, our discoveries offer valuable references for decision-makers and government agencies in formulating scientifically effective carbon reduction policies. As the urgency of addressing climate change continues to grow, the progress made in this paper can contribute to a more sustainable and environmentally conscious future.

Discussion

In this paper, we emphasize the potential of deep learning techniques in carbon emission prediction and demonstrate the effectiveness of the TCN-LSTM combination architecture. The significant contribution of this research lies in providing a new approach to address the carbon emission prediction problem in time series data. Moreover, our study underscores the importance of data reliability and consistency for the successful application of models. We encourage further research and application of this method to facilitate the achievement of global carbon reduction goals.
Identification of MARK2, CCDC71, GATA2, and KLRC3 as candidate diagnostic genes and potential therapeutic targets for repeated implantation failure with antiphospholipid syndrome by integrated bioinformatics analysis and machine learning
Authors: Zhang Manli , Ge Ting , Zhang Yunian , La Xiaolin
Published: October 2023

Background

Antiphospholipid syndrome (APS) is a group of clinical syndromes of thrombosis or adverse pregnancy outcomes caused by antiphospholipid antibodies, which increase the incidence of in vitro fertilization failure in patients with infertility. However, the common mechanism of repeated implantation failure (RIF) with APS is unclear. This study aimed to search for potential diagnostic genes and potential therapeutic targets for RIF with APS.

Methods

To obtain differentially expressed genes (DEGs), we downloaded the APS and RIF datasets separately from the public Gene Expression Omnibus database and performed differential expression analysis. We then identified the common DEGs of APS and RIF. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses were performed, and we then generated protein-protein interaction. Furthermore, immune infiltration was investigated by using the CIBERSORT algorithm on the APS and RIF datasets. LASSO regression analysis was used to screen for candidate diagnostic genes. To evaluate the diagnostic value, we developed a nomogram and validated it with receiver operating characteristic curves, then analyzed these genes in the Comparative Toxicogenomics Database. Finally, the Drug Gene Interaction Database was searched for potential therapeutic drugs, and the interactions between drugs, genes, and immune cells were depicted with a Sankey diagram.

Results

There were 11 common DEGs identified: four downregulated and seven upregulated. The common DEG analysis suggested that an imbalance of immune system-related cells and molecules may be a common feature in the pathophysiology of APS and RIF. Following validation, MARK2, CCDC71, GATA2, and KLRC3 were identified as candidate diagnostic genes. Finally, Acetaminophen and Fasudil were predicted as two candidate drugs.

Conclusion

Four immune-associated candidate diagnostic genes (MARK2, CCDC71, GATA2, and KLRC3) were identified, and a nomogram for RIF with APS diagnosis was developed. Our findings may aid in the investigation of potential biological mechanisms linking APS and RIF, as well as potential targets for diagnosis and treatment.
Bacterial and fungal characterization of pancreatic adenocarcinoma from Endoscopic Ultrasound-guided biopsies
Authors: Wright Robin D. , Bartelli Thais F. , Baydogan Seyda , White James Robert , Kim Michael P. , Bhutani Manoop S. , McAllister Florencia
Published: October 2023

Introduction

The tumor microbiome (TM) has been linked to pancreatic cancer prognosis. Specific microbes can confer tumor resistance to therapies. Early knowledge of the TM at time of diagnosis would be clinically relevant for precision therapy based on microbial composition. However, it is difficult to define the TM prior to surgical resection.

Methods

In this pilot feasibility study, patients underwent Endoscopic Ultrasound-Fine Needle Aspiration (EUS-FNA) biopsy of pancreatic adenocarcinoma. These samples were analyzed using 16S rRNA and internal transcribed spacer (ITS) sequencing for characterization of the tumor bacteria and fungi.

Result

After in silico decontamination and comparison to non-matched tumor, we were able to characterize the TM in biopsies, which was comparable to the TM from surgical specimens.

Discussion

EUS-FNA biopsy may represent a feasible modality to characterize the pancreatic TM prior to surgical resection with proper decontamination strategies and improvements in matched controls.
Transcriptional responses of liver and spleen in Lota lota to polyriboinosinic polyribocytidylic acid
Authors: Lou Fangrui , Zhang Yuan , Xu Anle , Gao Tianxiang
Published: October 2023

Introduction

The cultured Lota lota can meet the market demand in the context of the decline of wild resources, but the disease in the high-density culture process also deserves attention. Therefore, understanding the immune regulation mechanisms of L. lota will be the basis for obtaining high benefits in artificial culture.

Methods

To explore the viral response mechanism of L. lota, RNA-seq was applied to identify the transcriptomic changes of the liver and spleen in L. lota by poly (I:C) stress.

Results

The DEGs (liver: 2186 to 3123; spleen 1542 to 2622) and up-regulated genes (liver: 1231 to 1776; spleen 769 to 1502) in the liver and spleen increased with the prolongation (12h to 48h) of poly (I:C)-stimulation time. This means L. lota needs to mobilize more functional genes in response to longer periods of poly (I:C)-stimulation. Despite the responses of L. lota to poly (I:C) showed tissue-specificity, we hypothesized that both liver and spleen of L. lota can respond to poly (I:C) challenge may be through promoting apoptosis of DNA-damaged cells, increasing the activity of immune-enhancing enzymes, and increasing energy supply based on DEGs annotation information.

Conclusions

Our results demonstrate the transcriptional responses of L. lota to poly (I:C)-stimulation, and these data provide the first resource on the genetic regulation mechanisms of L. lota against viruses. Furthermore, the present study can provide basic information for the prevention of viral diseases in L. lota artificial culture process.
Relapsed refractory multiple myeloma with CNS involvement successfully treated with Elranatamab: first reported case
Authors: Mutlu Yasa Gul , Yıgıt Kaya Sureyya , Maral Senem , Melek Elif , Baslar Zafer , Kaynar Leylagul , Sevindik Omur Gokmen
Published: October 2023

Central nervous system (CNS) involvement in multiple myeloma (MM) is a rare and challenging complication associated with poor prognosis and limited treatment options. Emerging T-cell directing therapies, such as bispecific antibodies (bsAbs) and chimeric antigen receptor T cells (CAR-T), have shown remarkable success in treating MM, but their efficacy in CNS involvement remains unclear. Elranatamab, a humanized bispecific antibody targeting B-cell maturation antigen (BCMA) and CD3-expressing T cells, has demonstrated promising results in relapsed refractory MM. However, its efficacy in treating CNS-MM has not been reported. We present a case of a 37-year-old male MM patient with CNS involvement who has been successfully treated with Elranatamab.
Environmental drivers and the distribution of cold-water corals in the global ocean
Authors: Tong Ruiju , Davies Andrew J. , Yesson Chris , Yu Jinsongdi , Luo Yuan , Zhang Ling , Burgos Julian M.
Published: October 2023

Species distribution models (SDMs) are useful tools for describing and predicting the distribution of marine species in data-limited environments. Outputs from SDMs have been used to identify areas for spatial management, analyzing trawl closures, quantitatively measuring the risk of bottom trawling, and evaluating protected areas for improving conservation and management. Cold-water corals are globally distributed habitat-forming organisms that are vulnerable to anthropogenic impacts and climate change, but data deficiency remains an ongoing issue for the effective spatial management of these important ecosystem engineers. In this study, we constructed 11 environmental seabed variables at 500 m resolution based on the latest multi-depth global datasets and high-resolution bathymetry. An ensemble species distribution modeling method was used to predict the global habitat suitability for 10 widespread cold-water coral species, namely, 6 Scleractinian framework-forming species and 4 large gorgonian species. Temperature, depth, salinity, terrain ruggedness index, carbonate saturation state, and chlorophyll were the most important factors in determining the global distributions of these species. The Scleractinian Madrepora oculata showed the widest niche breadth, while most other species demonstrated somewhat limited niche breadth. The shallowest study species, Oculina varicosa, had the most distinctive niche of the group. The model outputs from this study represent the highest-resolution global predictions for these species to date and are valuable in aiding the management, conservation, and continued research into cold-water coral species.
Symbiotic Wolbachia in mosquitoes and its role in reducing the transmission of mosquito-borne diseases: updates and prospects
Authors: Minwuyelet Awoke , Petronio Giulio Petronio , Yewhalaw Delenasaw , Sciarretta Andrea , Magnifico Irene , Nicolosi Daria , Di Marco Roberto , Atenafu Getnet
Published: October 2023

Mosquito-borne diseases such as malaria, dengue fever, West Nile virus, chikungunya, Zika fever, and filariasis have the greatest health and economic impact. These mosquito-borne diseases are a major cause of morbidity and mortality in tropical and sub-tropical areas. Due to the lack of effective vector containment strategies, the prevalence and severity of these diseases are increasing in endemic regions. Nowadays, mosquito infection by the endosymbioticWolbachiarepresents a promising new bio-control strategy. Wild-infected mosquitoes had been developing cytoplasmic incompatibility (CI), phenotypic alterations, and nutrition competition with pathogens. These reduce adult vector lifespan, interfere with reproduction, inhibit other pathogen growth in the vector, and increase insecticide susceptibility of the vector. Wild, uninfected mosquitoes can also establish stable infections through trans-infection and have the advantage of adaptability through pathogen defense, thereby selectively infecting uninfected mosquitoes and spreading to the entire population. This review aimed to evaluate the role of theWolbachiasymbiont with the mosquitoes (Aedes, Anopheles,andCulex) in reducing mosquito-borne diseases. Global databases such as PubMed, Web of Sciences, Scopus, and pro-Quest were accessed to search for potentially relevant articles. We used keywords:Wolbachia,Anopheles,Aedes,Culex, and mosquito were used alone or in combination during the literature search. Data were extracted from 56 articles’ texts, figures, and tables of the included article.
Emerging quantum hybrid systems for non-Abelian-state manipulation
Authors: Muralidharan Bhaskaran , Kumar Manohar , Li Chuan
Published: October 2023

The non-Abelian state has garnered considerable interest in the field of fundamental physics and future applications in quantum computing. In this review, we introduce the basic ideas of constructing the non-Abelian states in various systems from 1D to 3D and discuss the possible approaches to detect these states, including the Majorana bound states in a hybrid device and the v = 5/2 state in a fractional quantum Hall system.
The increasing instance of negative emotion reduce the performance of emotion recognition
Authors: Wang Xiaomin , Zhao Shaokai , Pei Yu , Luo Zhiguo , Xie Liang , Yan Ye , Yin Erwei
Published: October 2023

Introduction

Emotion recognition plays a crucial role in affective computing. Recent studies have demonstrated that the fuzzy boundaries among negative emotions make recognition difficult. However, to the best of our knowledge, no formal study has been conducted thus far to explore the effects of increased negative emotion categories on emotion recognition.

Methods

A dataset of three sessions containing consistent non-negative emotions and increased types of negative emotions was designed and built which consisted the electroencephalogram (EEG) and the electrocardiogram (ECG) recording of 45 participants.

Results

The results revealed that as negative emotion categories increased, the recognition rates decreased by more than 9%. Further analysis depicted that the discriminative features gradually reduced with an increase in the negative emotion types, particularly in the θ, α, and β frequency bands.

Discussion

This study provided new insight into the balance of emotion-inducing stimuli materials.
Towards a hybrid approach to unveil the Chimaira of neurosciences: philosophy, aperiodic activity and the neural correlates of consciousness
Authors: Ladas Aristea I. , Gravalas Triantafyllos , Stoneham Tom , Frantzidis Christos A.
Published: October 2023

Contemporary theories of consciousness, although very efficient in postulating testable hypotheses, seem to either neglect its relational aspect or to have a profound difficulty in operationalizing this aspect in a measurable manner. We further argue that the analysis of periodic brain activity is inadequate to reveal consciousness’s subjective facet. This creates an important epistemic gap in the quest for the neural correlates of consciousness. We suggest a possible solution to bridge this gap, by analysing aperiodic brain activity. We further argue for the imperative need to inform neuroscientific theories of consciousness with relevant philosophical endeavours, in an effort to define, and therefore operationalise, consciousness thoroughly.
Determining classes of food items for health requirements and nutrition guidelines using Gaussian mixture models
Authors: Balakrishna Yusentha , Manda Samuel , Mwambi Henry , van Graan Averalda
Published: October 2023

Introduction

The identification of classes of nutritionally similar food items is important for creating food exchange lists to meet health requirements and for informing nutrition guidelines and campaigns. Cluster analysis methods can assign food items into classes based on the similarity in their nutrient contents. Finite mixture models use probabilistic classification with the advantage of taking into account the uncertainty of class thresholds.

Methods

This paper uses univariate Gaussian mixture models to determine the probabilistic classification of food items in the South African Food Composition Database (SAFCDB) based on nutrient content.

Results

Classifying food items by animal protein, fatty acid, available carbohydrate, total fibre, sodium, iron, vitamin A, thiamin and riboflavin contents produced data-driven classes with differing means and estimates of variability and could be clearly ranked on a low to high nutrient contents scale. Classifying food items by their sodium content resulted in five classes with the class means ranging from 1.57 to 706.27 mg per 100 g. Four classes were identified based on available carbohydrate content with the highest carbohydrate class having a mean content of 59.15 g per 100 g. Food items clustered into two classes when examining their fatty acid content. Foods with a high iron content had a mean of 1.46 mg per 100 g and was one of three classes identified for iron. Classes containing nutrient-rich food items that exhibited extreme nutrient values were also identified for several vitamins and minerals.

Discussion

The overlap between classes was evident and supports the use of probabilistic classification methods. Food items in each of the identified classes were comparable to allowed food lists developed for therapeutic diets. This data-driven ranking of nutritionally similar classes could be considered for diet planning for medical conditions and individuals with dietary restrictions.
Factors influencing adherence to non-communicable disease medication in India: secondary analysis of cross-sectional data from WHO - SAGE2
Authors: Tolley Abraham , Grewal Kirpal , Weiler Alessa , Papameletiou Anna Maria , Hassan Refaat , Basu Saurav
Published: October 2023

Background: Non-communicable diseases (NCDs) are a leading cause of death globally and disproportionately affect those in low- and middle-income countries lower-middle-income countries. Poor medication adherence among patients with NCDs is prevalent in India due to lack of initiation, missed dosing or cessation of treatment, and represents a growing healthcare and financial burden.

Objective: This study aimed to identify factors influencing medication adherence in adults with NCDs in India.

Methods: We performed a cross-sectional study, conducting secondary data analysis on the second wave of the World Health Organisation’s ‘Study on global AGEing and adult health (SAGE)’, a survey that collected data from predominantly older adults across India. Bivariate analysis and multivariate logistic regression modelling were conducted to specifically interrogate the reasons for lack of initiation and cessation of treatment. Reporting of this study was informed by the STROBE guidelines.

Results: The average medication adherence rate was 51% across 2,840 patients with one or more NCDs, reflecting non-initiation and lack of persistence of treatment. The strongest factor significantly predicting non-adherence to medication across these components was multimorbidity (odds ratio 0.47, 95% CI 0.40–0.56). Tobacco use (OR = 0.76, CI 0.59–0.98) and never having attended school (OR = 0.75, CI 0.62–0.92) were significantly associated with poor medication adherence (p < 0.05) while rural living (OR = 0.70, CI 0.48–1.02), feelings of anxiety (OR = 0.84, CI 0.66–1.08) and feelings of depression (OR = 0.90, CI 0.70–1.16) were factors lacking statistically significant association with medication adherence on multivariate analysis. Older age (OR = 2.02, CI 1.51–2.71) was significantly associated with improved medication adherence whilst there was a weak association between increased wealth and improved medication use.

Limitations: The SAGE2 survey did not capture whether patients were taking their medication doses according to prescribed instructions—as a result our findings may under-estimate the true prevalence of medication non-adherence.

Conclusion: Our analysis provides evidence that poor medication adherence in India is multifactorial, with distinct socioeconomic and health-system factors interacting to influence patient decision making. Future large-scale surveys interrogating adherence should assess all components of adherence specifically, whilst public health interventions to improve medication adherence should focus on barriers that may exist due to multimorbidity, comorbid depression and anxiety, and low educational status.
Case report: Remarkable response to sintilimab, lenvatinib, and nab-paclitaxel in postoperative metastatic chemotherapy-resistant combined hepatocellular-cholangiocarcinoma
Authors: Zhou Nan , Lei Chuan-Fen , Tan Si-Rui , Huang Qi-Yue , Zhang Shun-Yu , Liang Zheng-Xin , Gou Hong-Feng
Published: October 2023

Background: Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) is a highly aggressive malignancy with a poor prognosis. However, there are no consensus treatment guidelines, and decisions are usually extrapolated from intrahepatic cholangiocarcinoma (ICC) or hepatocellular carcinoma (HCC). Given that cHCC-CCA owns the unequivocal presence of both hepatocytic and cholangiocytic differentiation, a combination regimen of anti-PD1 antibody, multikinase inhibitor, and chemotherapy targeting against both components might be an optimal choice.

Case presentation: We present the case of a patient with postoperative metastatic chemotherapy-resistant cHCC-CCA who exhibited a durable response and reasonable tolerability to a combination therapy consisting of the anti-PD1 antibody sintilimab, multikinase inhibitor lenvatinib, and nab-paclitaxel, despite having a low tumor mutational burden (TMB-L), microsatellite stability (MSS), and negative programmed cell death 1 ligand 1 (PD-L1).

Conclusion: The combination regimen of immune checkpoint inhibitor sintilimab, multikinase inhibitor lenvatinib, and chemotherapy with nab-paclitaxel, which targets both the HCC and ICC components, may represent a promising treatment option for patients with cHCC-CCA. Further research is warranted to validate these findings in larger patient cohorts.
Muscle synergies in joystick manipulation
Authors: Cai Liming , Yan Shuhao , Ouyang Chuanyun , Zhang Tianxiang , Zhu Jun , Chen Li , Ma Xin , Liu Hui
Published: October 2023

Extracting muscle synergies from surface electromyographic signals (sEMGs) during exercises has been widely applied to evaluate motor control strategies. This study explores the relationship between upper-limb muscle synergies and the performance of joystick manipulation tasks. Seventy-seven subjects, divided into three classes according to their maneuvering experience, were recruited to perform the left and right reciprocation of the joystick. Based on the motion encoder data, their manipulation performance was evaluated by the mean error, standard deviation, and extreme range of position of the joystick. Meanwhile, sEMG and acceleration signals from the upper limbs corresponding to the entire trial were collected. Muscle synergies were extracted from each subject’s sEMG data by non-negative matrix factorization (NMF), based on which the synergy coordination index (SCI), which indicates the size of the synergy space and the variability of the center of activity (CoA), evaluated the temporal activation variability. The synergy pattern space and CoA of all participants were calculated within each class to analyze the correlation between the variability of muscle synergies and the manipulation performance metrics. The correlation level of each class was further compared. The experimental results evidenced a positive correlation between manipulation performance and maneuvering experience. Similar muscle synergy patterns were reflected between the three classes and the structure of the muscle synergies showed stability. In the class of rich maneuvering experience, the correlation between manipulation performance metrics and muscle synergy is more significant than in the classes of trainees and newbies, suggesting that long-term training and practicing can improve manipulation performance, stability of synergy compositions, and temporal activation variability but not alter the structure of muscle synergies determined by a specific task. Our approaches and findings could be applied to 1) reduce manipulation errors, 2) assist maneuvering training and evaluation to enhance transportation safety, and 3) design technical support for sports.