bluuebunny/crossref_metadata_2025 huggingface dataset:
A compact and high-performance setup of capillary electrophoresis with capacitively coupled contactless conductivity detection (CE-C4D)
Authors: Li Lin , Song Yun-Peng , Ren Dou-Dou , Li Tang-Xiu , Gao Ming-Hui , Zhou Lei , Zeng Zhi-Cong , Pu Qi-aosheng
Published: April 2024

A compact CE-C4D instrument with trace analysis sensitivity  (e.g. 1 ppb or 20 nM level for common inorganic ions) without the need for preconcentration methods has been successfully developed.
A LAMP-based hydrogen ion selective electrochemical sensor for highly sensitive detection of Mycoplasma pneumoniae
Authors: Wang Huiqing , Li Yang , Tian Lin , Li Xinyi , Gao Qian , Liu Yaru , Ma Cuiping , Wang Qing , Shi Chao
Published: April 2024

Simple, rapid, and accurate detection of M. pneumonia was achieved using a portable handheld POCT platform, with the entire testing process being completed within 30 minutes.
Ionic liquid-functionalized metal organic frameworks and their composite membranes for enhanced proton transport
Authors: Song Jeong Hwa , Koo Seyoung , Kang Dong Won
Published: April 2024

Post-synthetic modification with ionic liquids is gaining prominence as a highly effective strategy for enhancing proton conductivity in metal–organic frameworks without significant structural changes.
Noble-metal-free bimetallic nitride decorated CdS nanorods for photocatalytic hydrogen generation
Authors: Chen Lu , Xia Yuzhou , Shi Jiale , Huang Xiaohui , Liu Xiyao , Yan Guiyang , Huang Renkun
Published: April 2024

The Ni3FeN/CdS photocatalyst exhibits a remarkable photocatalytic hydrogen production rate of 4.6 mmol g−1 h−1, which is 23.8 times higher than that of pristine CdS. Its apparent quantum efficiency is 13.5% at 420 nm.
Enhanced Zn ion storage performance of a polypyrrole-coated Mn3O4 composite electrode
Authors: Li Shilong , Zhao Ming , Zhang Wei-chao , Wu Xiang
Published: April 2024

The Mn3O4@PPy cathode material is prepared by a simple hydrothermal method. The assembled Zn//Mn3O4@PPy cells deliver a discharge capacity of 491.5 mA h g−1 at 0.1 A g−1. They maintain 96% of the original capacity at 2 A g−1 after 1200 cycles.
Photolytic splitting of homodimeric quinone-derived oxetanes studied by ultrafast transient absorption spectroscopy and quantum chemistry
Authors: Blasco-Brusola Alejandro , Tamarit Lorena , Navarrete-Miguel Miriam , Roca-Sanjuán Daniel , Miranda Miguel A. , Vayá Ignacio
Published: April 2024

The photocleavage of homodimeric quinone oxetanes evolves through a non-adiabatic process, the opposite of what has been observed with heterodimeric oxetanes. This is explained by ultrafast transient absorption spectroscopy and quantum chemistry.
Atomic insights into the interaction of N2, CO2, NH3, NO, and NO2 gas molecules with Zn2(V, Nb, Ta)N3 ternary nitride monolayers
Authors: Kistanov Andrey A.
Published: April 2024

The search for promising carrier blocking layer materials with high stability, including resistance to surface inhibition by environmental molecules that cause a drop in carrier mobility, is critical for the production of tandem solar cells.
La doping greatly enhances electrochemical alkaline seawater oxidation over Ni(OH)2 nanosheet
Authors: Tang Wenjing , Zou Jie , Li Zixiao , Zhang Xuefeng , Xie Ting , Li Jun , He Xun , Tang Xiaolan , Liu Xuwei , Chu Wei , Farouk Asmaa , Hamdy Mohamed S. , Yang Yingchun , (Walter) Hu Wenchuang , Sun Xuping
Published: April 2024

An La–Ni(OH)2/NF catalyst exhibits superior performance for alkaline seawater oxidation, requiring a low overpotential of 434 mV to achieve a current density of 500 mA cm−2.
X-ray absorption and emission spectroscopy of N2S2 Cu(ii)/(iii) complexes
Authors: Geoghegan Blaise L. , Bilyj Jessica K. , Bernhardt Paul V. , DeBeer Serena , Cutsail George E.
Published: April 2024

The competing influences of both oxidation state and ligand protonation state in Cu(ii) and Cu(iii) Schiff base complexes are explored through copper K-edge X-ray absorption and valence-to-core emission spectroscopies along with DFT calculations.
α-Zirconium hydrogenophosphate as a nano-container of 2-aminobenzimidazole for the corrosion protection of zinc in NaCl medium
Authors: Bouali I. , Rocca E. , Veys-Renaux D. , Rhouta B. , Khalil A.
Published: April 2024

α-Zirconium hydrogenophosphate constitutes an efficient nanocontainer which releases the corrosion inhibitor 2-aminobenzimidazole upon contact with Na+ and buffers the local pH.
Mapping inorganic crystal chemical space
Authors: Park Hyunsoo , Onwuli Anthony , Butler Keith T. , Walsh Aron
Published: April 2024

We enumerate binary, ternary, and quaternary element and species combinations and present a two-dimensional representation of inorganic crystal chemical space, labelled according to whether the combinations pass standard chemical filters and if they appear in known databases.
Aqueous Zn–CO2 batteries: a route towards sustainable energy storage
Authors: Liu Yanxiu , Chen Junjie , Li Weichen , Zhang Yu , Fu Xianwei , Li Erling , Jin Shangbin , Yang Li-Ming , Tian Zhihong , Antonietti Markus , Liu Tianxi
Published: April 2024

This review systematically summarizes the working principles and devices, and the different types of catalytic cathodes used for Zn–CO2 batteries. The challenges and prospects in this field are also particularly discussed.
A heterostructure nanofiber film with an enhanced internal electrical field and surface plasmon resonance for efficient microbial removal
Authors: Li Wanting , Yang Jing , Gao Xin , Fu Yiqian , He Huiyu , Wang Pu , Hou Yudong , Zhu Mankang , Wang Xiu-Hong
Published: April 2024

An electrospun Ag@BTO/PVDF fiber film with high β phase content and enhanced built-in electrical field for highly efficient photo-piezocatalytic removal of water pollutants and microorganisms.
A molecular-design approach for selective sulfate separation from competitive acidic and alkaline aqueous media
Authors: Basu Arghya , Dey Sandeep Kumar
Published: April 2024

The review encompasses an in-depth understanding of the choice of suitable anion receptors for recognition-guided selective sulfate separation from acidic and alkaline aqueous solutions containing several other competing ions.
Polycatechols inhibit ferroptosis and modulate tau liquid–liquid phase separation to mitigate Alzheimer's disease
Authors: Moorthy Hariharan , Ramesh Madhu , Padhi Dikshaa , Baruah Prayasee , Govindaraju Thimmaiah
Published: April 2024

Polycatechols modulate amyloid-associated toxicities, arrest labile iron, inhibit lipid peroxidation, and regulate tau liquid–liquid phase separation (LLPS) to mitigate the pathological nexus between ferroptosis and AD.
PerSEveML: a web-based tool to identify persistent biomarker structure for rare events using an integrative machine learning approach
Authors: Dutta Sreejata , Mudaranthakam Dinesh Pal , Li Yanming , Sardiu Mihaela E.
Published: April 2024

Detecting rare event signatures in omics data can pose computational challenges. PerSEveML employs an integrative machine learning approach to address these obstacles and identify a persistent feature structure.
Mechanochemistry enabled highly efficient solvent-free deoxygenation of phosphine oxides in air
Authors: Kubota Koji , Hisazumi Reon , Seo Tamae , Ito Hajime
Published: April 2024

We demonstrate that a mechanochemical protocol enables the highly efficient solvent-free deoxygenation of phosphine oxides with hydrosilanes in the presence of a phosphoric acid additive.
Layer-dependent ultrafast carrier dynamics of PdSe2 investigated by photoemission electron microscopy
Authors: Lyu Xiaying , Li Yaolong , Li Xiaofang , Liu Xiulan , Xiao Jingying , Xu Weiting , Jiang Pengzuo , Yang Hong , Wu Chengyin , Hu Xiaoyong , Peng Liang-You , Gong Qihuang , Yang Shengxue , Gao Yunan
Published: April 2024

This study utilized time- and energy-resolved photoemission electron microscopy with ultrahigh spatial resolution and wide-field real-time detection advantages to reveal the layer-dependent ultrafast dynamics of excited-state electrons in PdSe2.
Phosphorus-rich CoP4@N–C nanoarrays for efficient nitrate-to-ammonia electroreduction
Authors: Lu Xinyu , Leng Yanqiu , Su Lei , Zhang Baojian , Zhao Jinxiu , Ren Xiang , Wei Qin
Published: April 2024

The electrochemical nitrate reduction reaction (NO3−RR) is a novel green method for ammonia synthesis.
Design, synthesis, and biological application of A–D–A-type boranil fluorescent dyes
Authors: Luo Wei , Li Yiling , Wang Liang , Qin Yanhua , Cheng Qiao , Hu Guochang , Yao Chaoyi , Song Xiangzhi
Published: April 2024

Acceptor–donor–acceptor boranil fluorescent dyes, CSU-BF-R (R = H, CH3, and OCH3), were developed with strong red fluorescence and large Stokes shifts. CSU-BF-OCH3 could selectively sense intracellular hypochlorous acid in living cells and zebrafish.
Recent developments in the enzymatic modifications of steroid scaffolds
Authors: Wang Huibin , Abe Ikuro
Published: April 2024

This review highlights the recent advancements in the enzymatic modifications of steroid scaffolds, emphasizing enzymatic hydroxylation, ketoreduction, dehydrogenation, enzymatic cascade reactions, and other modifications.
Synthesis of poly(methylsilsesquioxane-co-dimethylsiloxane) liquids and deep-ultraviolet transparent elastic resins through co-solvent-free water-rich hydrolytic polycondensation of organoalkoxysilanes
Authors: Yoshida Takuma , Ishijima Masanao , Yoshida Satoshi , Koike Akio , Kajihara Koichi
Published: April 2024

A co-solvent-free hydrolytic polycondensation of mono- and dimethylmethoxysilanes at high H2O/Si ratios (≳10) gave methylsilsesquioxane-rich (80 mol%) liquids heat-curable to stiff, tough, and deep-UV transparent resins showing full elastic recovery.
Crystallization-driven self-assembly of poly(3-hexylthiophene)-b-poly(2,5-bis(2-ethylhexyloxy)p-phenylene), a π-conjugated diblock copolymer with a rigid rod corona-forming block
Authors: Vespa Marcus , MacFarlane Liam R. , Hudson Zachary M. , Manners Ian
Published: April 2024

Crystallization-driven self-assembly is used to form nanofibers several microns in length using diblock copolymers with rigid polythiophene and polyphenylene blocks.
Solar heating catalytic formic acid dehydrogenation by graphene-porous foam-supported tungsten nitride nanoparticles
Authors: Chang Jiarong , Hao Tianhua , Lv Cuncai , Xu Maoyu , Zhang Deyi , Gao Linjie , Ning Shangbo , Li Yaguang , Ye Jinhua
Published: April 2024

WN/Gr PF exhibits significant solar heating catalytic formic acid dehydrogenation and the rate exceeds those of other reported photocatalysts.
Visible-light-induced [1,3]-brook rearrangements of α-ketoacylsilanes and their subsequent trapping in a tandem annulation with 1,3,5-triazinanes and azomethine imines
Authors: Zhang Zhong , Wu Sirui , Zhou Yuqiao , Li Bao-Lin , Xiao Siyue , Zhao Xiaohu , Yu Zhipeng
Published: April 2024

An unusual visible-light-induced [1,3]-brook rearrangement of α-ketoacylsilanes for cascade cyclization with 1,3,5-triazinanes and C,N-cyclic azomethine imines has been realized to assemble various β-lactams and pyrazolidinone scaffolds.
Diverting the Mannich reaction to access 2,2-disubstituted indolin-3-ones by merging 1,2-aryl migration and copper-catalyzed aerobic oxidation
Authors: Xiang Jia-Chen , Wang Yu-Die , Yuan Peng , Zhu Hui-Min , Lei Tong , Wu An-Xin , Liao Zhixin
Published: April 2024

Three typical substrates for the Mannich reaction, p-anisidine, aldehyde, and a nucleophile, did not afford the predictable linear Mannich base under an aerobic copper oxidation condition, but rendering a 2,2-disubstituted indolin-3-one product.
Sustained free chlorine-releasing polydimethylsiloxane/Ca(ClO)2 materials with long-lasting disinfection efficacy
Authors: Su Xiaofan , Lin Yaqi , Hu Xingyu , Tan Xinzhi , Mai Yao , Jiang Minyan , Zhang Ruitao , Huo Fangjun , Liu Lei , Tian Weidong , Xie Li
Published: April 2024

The article introduces a new PDMS/Ca(ClO)2 material that releases chlorine over two weeks, effectively combating bacterial growth, and suggesting versatile applications in biomedical and industrial disinfection.
A prediction model for CO2/CO adsorption performance on binary alloys based on machine learning
Authors: Cao Xiaofeng , Luo Wenjia , Liu Huimin
Published: April 2024

Machine-learning models were constructed to accurately predict CO2 and CO adsorption affinity on a wide range of binary alloying.
Aluminum and polyanion-doping to improve structural and moisture stability of Ni-rich layered oxides for lithium-ion batteries
Authors: Mo Yan , Wu Yingke , Yuan Guohui , Li ZiKun , Zhang Meng
Published: April 2024

The substitution of Al3+ and PO34− in LiNi0.8Co0.1Mn0.1O2 material is favorable for stabilizing the layered structure against the undesired phase transition of H2 to H3 as well as the contamination of ambient air.
Synergistic effects of the bimetallic Ni–Fe systems and their application in the reductive amination of polyether polyols
Authors: He Ruiying , Zhu Zhongpeng , Zheng Weiping , Jia Dandan , Fu Zhaolin , Wu Mingqing , Zhao Jie , Wang Sheng , Tao Zhiping
Published: April 2024

We report the synthesis of xNi–yFe/γ-Al2O3 catalysts which were applied to the reductive amination of polypropylene glycol (PPG) for the preparation of polyether amine (PEA).
Amorphous conversion in pyrolytic symmetric trinuclear nickel clusters trigger trifunctional electrocatalysts
Authors: Li Li , Zhao Hui-Feng , Gan Mei-Xing , Zhang Tao , Li Jia-Ning , Tao Shi , Peng Jing , Yu Hai-Bin , Peng Xu
Published: April 2024

This work elucidates the structural transformation of trinuclear nickel molecular clusters from crystalline to amorphous phases during pyrolysis, Specifically, Ni2, Ni1, and Ni1′ sites demonstrate selectively enhanced electrocatalytic activity.
Fluorescence coding techniques for RNA detection
Authors: Wang Junren , Xiang Qin , Dong Haifeng , Zhang Xueji
Published: April 2024

Schematic illustration of fluorescence coding techniques in RNA detection.
Flexible hydrogels connecting adhesion and wetting
Authors: Kim A-Reum , Mitra Surjyasish , Shyam Sudip , Zhao Boxin , Mitra Sushanta K.
Published: April 2024

Soft, flexible hydrogels enable researchers to connect two discrete regimes: liquid wetting to contact adhesion in solids.
Facile synthesis of polycarbonates from biomass-based eugenol: catalyst optimization for selective copolymerization of CO2 and eugenol to achieve polycarbonates
Authors: Sengoden Mani , Bhat Gulzar A. , Roland Tristan , Hsieh Chia-Min , Darensbourg Donald J.
Published: April 2024

A series of Co(iii) and Cr(iii)(salen) complexes in the presence of onium salts have been examined for the coupling of CO2 and biomass based eugenol epoxide for the selective production of polycarbonates in a partially sustainable process.
Deciphering the role of 2D graphene oxide nanofillers in polymer membranes for vanadium redox flow batteries
Authors: Thangarasu Sadhasivam , Shalu  , Palanisamy Gowthami , Sadhasivam Subramani , Selvakumar Karuppaiah , Eswar Neerugatti Krishna Rao , Oh Tae Hwan
Published: April 2024

This comprehensive review article explains the influence of various GO and GO-polymer membrane modifications for VRFB, which range from cation and anion exchange to amphoteric and zwitterionic membranes.
Symmetry-induced modulation of proton conductivity in Y-doped Ba(Zr,Ce)O3: insights from Raman spectroscopy
Authors: Yang Yiming , Lu Jiachen , Zhang Xinyu , Shi Yanuo , Du Peng , Ling Xiao , Yang Nan , Chen Qianli
Published: April 2024

Quantitative comparison of crystal symmetry and lattice volume effects on the proton conductivity of Y-doped Ba(Zr,Ce)O3 epitaxial films to polycrystalline bulk materials reveals that lower crystal symmetry correlates with higher activation energy.
Design of interfacial dual Schottky junctions to modulate charge transfer for enhanced piezo-assisted photocatalytic degradation RhB performances
Authors: Jiang Xiaoqi , Sun Shengdong , Wang Yuqiao , Zhao Lebing , Huang Fangzhi , Li Shikuo
Published: April 2024

Construction of piezo-assisted interfacial dual Schottky junction to regulate charge transfer and surface reaction rate for the photocatalytic degradation of RhB.
In situ analysis of the oxygen evolution reaction on the CuO film in alkaline solution by surface interrogation scanning electrochemical microscopy: investigating active sites (CuIII) and kinetics
Authors: Han Seokjun , Yoo Jinoh , Choi Won Tae
Published: April 2024

Surface interrogation scanning electrochemical microscopy was employed to assess the electrocatalytic activity of CuO films for the oxygen evolution reaction in an alkaline solution.
Photothermal conversion-enabled temperature modulation for the growth of complex polymorphic architectures of calcium carbonate
Authors: Shi Boning , Zhang Lifu , Yang Zeda , Deng Jiangnan , An Shun , Fu Benwei , Song Chengyi , Tao Peng , Deng Tao , Shang Wen
Published: April 2024

Stepwise temperature modulation was realized by the photothermal conversion process, which enabled the growth of complex architectures of CaCO3 that are composed of multiple polymorphic phases.
Structure/interface synergy stabilizes high-nickel cathodes for lithium-ion batteries
Authors: Mao Guihong , Zeng Liming , Yang Jieyu , Yao Tengyu , Xiao Fangming , Tang Renheng , Shu Xin , Wang Ying , Shen Laifa
Published: April 2024

Innovatively adopting a dual thermally stabilized synergistic strategy, a stable Al-doped and heat-resistant MoO3-coated cathode, LiNi0.928Co0.072O2, was fabricated.
Ca@Cu-CD nanoprobe for dual detection of glycine and ex vivo glycine imaging
Authors: Behera Lingaraj , Mishra Lopamudra , Mishra Monalisa , Mohapatra Sasmita
Published: April 2024

Hydrothermally prepared copper-doped carbon dots (Cu-CDs) were modified with Ca2+, which serve as an excellent platform for the recognition of glycine.
Interaction of Au(iii) with amino acids: a vade mecum for medicinal chemistry and nanotechnology
Authors: Mattioli Edoardo Jun , Cipriani Beatrice , Zerbetto Francesco , Marforio Tainah Dorina , Calvaresi Matteo
Published: April 2024

A systematic computational analysis is performed to determine the broad principles that govern the binding between amino acids and Au(iii).
Detecting labile heme and ferroptosis through ‘turn-on’ fluorescence and lipid droplet localization post Fe2+ sensing
Authors: Dubey Yogesh , Mansuri Shabnam , Kanvah Sriram
Published: April 2024

Development of fluorescent probes enables the sensitive detection of Fe2+ at nanomolar levels with guided lipid droplet imaging is discussed.
Biological applications of lipoic acid-based polymers: an old material with new promise
Authors: Yu Qing , Fang Zhiyue , Luan Shifang , Wang Lei , Shi Hengchong
Published: April 2024

This review highlights the ring-opening polymerization strategies of LA molecules and recent biomedical applications of PLA while discussing the challenges they face and future perspectives.
A facile solution processible self-rectifying and sub-1 V operating memristor via oxygen vacancy gradient within a TiO2 single layer
Authors: Park Min Ho , Jeong Jun Hyung , Kim Wonsik , Park Soohyung , Lim Byeong Min , Lee Hong-Sub , Kang Seong Jun
Published: April 2024

A sub-1 V operating memristor via oxygen vacancy gradient within a TiO2 single layer.
Tuning defects in Cu2O nanostructures via room temperature mechanical pressing: impacts on defect-dependent optical and photoelectrochemical sensing performances
Authors: Cai Yun , Zhou Wenyao , Wang Hongli , Bi Jiajie , Yu Fengjiao , Fang Jun , Yang Yang
Published: April 2024

Room temperature mechanical pressing is applied to specifically remediate oxygen vacancies in a defective Cu2O nanostructure, which provides information on the sensing performances of Cu2O through various defect-dependent mechanisms.
Efficient thermally activated delayed fluorophores featuring multi-donor arms and a π-extended acceptor core
Authors: Liu Bo , Chen Si-Wei , Chen Wen-Cheng , Xing Longjiang , Tan Ji-Hua , Wu Wei-Le , Liu Xiao-Long , Chen Jia-Xiong , Zhang Hao-Li , Huo Yanping
Published: April 2024

This study introduces a new molecular design for long-wavelength TADF emitters featuring multi-donor arms and a π-extended acceptor core, which can simultaneously mitigate solid-state emission quenching and promote reverse intersystem crossing.
Cross-cutting research and future directions under the GAPS networks
Authors: Harner Tom , Saini Amandeep , Shahpoury Pourya , Eng Anita , Schuster Jasmin K. , Kalisa Egide , Mastin Jacob
Published: April 2024

The GAPs networks are engaging in cross-cutting studies across fields of science and policy to address future challenges.
Gesture's Role in the Communication of Adults With Different Types of Aphasia
Authors: Ozturk Sumeyra , Özçalışkan Şeyda
Published: April 2024

Purpose:

Adults with aphasia gesture more than adults without aphasia. However, less is known about the role of gesture in different discourse contexts for individuals with different types of aphasia. In this study, we asked whether patterns of speech and gesture production of individuals with aphasia vary by aphasia and discourse type and also differ from the speech and gestures produced by adults without aphasia.

Method:

We compared the amount, diversity, and complexity of speech and gesture production in adults with anomic or Broca's aphasia and adults with no aphasia (
n
= 20/group) in their first- versus third-person narratives.

Results:

Adults with Broca's aphasia showed the lowest performance in their amount, diversity, and complexity of speech production, followed by adults with anomic aphasia and adults without aphasia. This pattern was reversed for gesture production. Speech and gesture production also varied by discourse context. Adults with either type of aphasia used a lower amount of and less diverse speech in third-person than in first-person narratives; this pattern was also reversed for gesture production.

Conclusions:

Overall, our results provide evidence for a compensatory role of gesture in aphasia communication. Adults with Broca's aphasia, who showed the greatest speech production difficulties, also relied most on gesture, and this pattern was particularly pronounced in the third-person narrative context.
Self-Rated Confidence in Vocal Emotion Recognition Ability: The Role of Gender
Authors: Sinvani Rachel-Tzofia , Fogel-Grinvald Haya , Sapir Shimon
Published: April 2024

Purpose:

We studied the role of gender in metacognition of voice emotion recognition ability (ERA), reflected by self-rated confidence (SRC). To this end, we guided our study in two approaches: first, by examining the role of gender in voice ERA and SRC independently and second, by looking for gender effects on the ERA association with SRC.

Method:

We asked 100 participants (50 men, 50 women) to interpret a set of vocal expressions portrayed by 30 actors (16 men, 14 women) as defined by their emotional meaning. Targets were 180 repetitive lexical sentences articulated in congruent emotional voices (anger, sadness, surprise, happiness, fear) and neutral expressions. Trial by trial, the participants were assigned retrospective SRC based on their emotional recognition performance.

Results:

A binomial generalized linear mixed model (GLMM) estimating ERA accuracy revealed a significant gender effect, with women encoders (speakers) yielding higher accuracy levels than men. There was no significant effect of the decoder's (listener's) gender. A second GLMM estimating SRC found a significant effect of encoder and decoder genders, with women outperforming men. Gamma correlations were significantly greater than zero for women and men decoders.

Conclusions:

In spite of varying interpretations of gender in each independent rating (ERA and SRC), our results suggest that both men and women decoders were accurate in their metacognition regarding voice emotion recognition. Further research is needed to study how individuals of both genders use metacognitive knowledge in their emotional recognition and whether and how such knowledge contributes to effective social communication.
Spelling Facilitates Reading: A Tutorial on the Spell-to-Read Approach
Authors: Ramsdell Heather L. , Bowers Lisa
Published: April 2024

Purpose:

According to the American Speech-Language-Hearing Association (ASHA), prevention, identification, assessment, and intervention of children who are learning to read and write are within the scope of practice for school-based speech-language pathologists (SLPs). Furthermore, for SLPs who work in the school setting, it is not uncommon to have struggling readers and poor spellers on their caseloads. Importantly, for students who have difficulty in spelling, their spelling errors are among the early indicators of dyslexia and can provide a means for identifying readers who may benefit from early intervention. SLPs can both assess spelling skills and implement evidence-based spelling and literacy diagnosis and instruction. Spelling instruction in kindergarten through the high school grades that is heavily grounded in metalinguistic activities can provide access to mental representations of word spellings, pronunciations, and meanings; links between whole-word and phonics approaches to reading instruction; and a foundation for reading fluency and comprehension.

Conclusions:

Learning to spell is essential for learning to read. Accordingly, this tutorial aims to elucidate how to (a) assess and identify phases of spelling development and (b) teach spelling to facilitate reading through a listening-first approach.
Matching area selection for arctic gravity matching navigation based on adaptive all‐field extended extremum algorithm
Authors: Xi Menghan , Wu Lin , Li Qianqian , Mao Guocheng , Wu Pengfei , Ji Bing , Bao Lifeng , Wang Yong
Published: April 2024

Suitable and effective matching area selection is crucial for gravity matching‐aided navigation. In this paper, an all‐field extended extremum algorithm based on an adaptive threshold (AT‐AEE) is proposed for matching area selection in the Arctic Sea. The gradient data is obtained by using the convolution of gravity reference graph data and all‐field extended extremum parameters. Then, the adaptive threshold method was employed to determine the optimal gradient threshold based on gravity anomaly data across various test areas. Data points with gradients exceeding the specified threshold are identified as local candidate points for matching areas. The test areas containing a certain proportion of local candidate points are designated as the suitable matching areas. Nine test areas in the Arctic Sea with different gravity change characteristics were chosen for simulation experiments to verify the performance of the proposed algorithm. Simulation experiments showed that superior navigation positioning results could be obtained in the matching areas selected by the AT‐AEE algorithm. Compared to traditional algorithm, the matching areas derived from the AT‐AEE algorithm performed with a better consistency in the gravity matching navigation results. In suitable matching areas with the proportion of local candidate points reaching 70%, the average positioning errors could be reduced to less than 1.5 n miles.
SuperCAM CO(3–2) APEX survey at a 6 pc resolution in the Small Magellanic Clouds
Authors: Saldaño H. P. , Rubio M. , Bolatto A. D. , Sandstrom K. , Swift B. J. , Verdugo C. , Jameson K. , Walker C. K. , Kulesa C. , Spilker J. , Bergman P. , Salazar G. A.
Published: April 2024

Context. The Small Magellanic Cloud (SMC) is an ideal laboratory for studying the properties of star-forming regions thanks to its low metallicity, which has an impact on the molecular gas abundance. However, a small number of molecular gas surveys of the entire galaxy have been carried out in the last few years, limiting the measurements of interstellar medium (ISM) properties in a homogeneous manner.

Aims. We present the CO(3-2) APEX survey at a 6 pc resolution of the bar of the SMC, observed with the SuperCAM receiver attached to the APEX telescope. This high-resolution survey has allowed us to study certain properties of the ISM and to identify CO clouds in the innermost parts of the H2 envelopes.

Methods. We adopted the CO analysis in the SMC bar comparing the CO(3–2) survey with that of the CO(2–1) of a similar resolution. We studied the CO(3–2)-to-CO(2–1) ratio (R32), which is very sensitive to the environment properties (e.g., star-forming regions). We analyzed the correlation of this ratio with observational quantities that trace the star formation such as the local CO emission, the Spitzer color [70/160], and the total IR surface brightness measured from the Spitzer and Herschel bands. For the identification of the CO(3–2) clouds, we used the CPROPS algorithm, which allowed us to measure the physical properties of the clouds. We analyzed the scaling relationships of such physical properties.

Results. We obtained R32 = 0.65 ± 0.02 for the SW bar and a slightly higher ratio, R32 = 0.7 ± 0.1, for N66 in the SMC. We found that R32 varies from region to region, depending on the star formation activity. In regions dominated by HII and photo-dissociated regions (e.g., N22, N66) R32 tends to be higher than the median values. Meanwhile, lower values were found toward quiescent clouds. We also found that R32 is correlated with the IR color [70/160] and the total IR surface brightness. This finding indicates that R32 increases with environmental properties, such as the dust temperature, total gas density, and radiation field. We identified 225 molecular clouds with sizes of R > 1.5 pc and signal-to-noise ratios (S/N) of >3, of which only 17 are well resolved CO(3–2) clouds with S/N ≳ 5. These 17 clouds follow consistent scaling relationships to the inner Milky Way clouds but with some departures. For instance, CO(3–2) tends to be less turbulent and less luminous than the inner Milky Way clouds of similar sizes. Finally, we estimated a median virial-based CO(3–2)-to-H2 conversion factor of 12.6−7+10 M⊙ (K km s−1 pc2)−1 for the total sample.
The impact of overshoot on thei-process in AGB stars
Authors: Remple B. A. , Battich T. , Weiss A.
Published: April 2024

Context.The production of neutron-rich elements at neutron densities intermediate to those of thes- andr-processes, the so-calledi-process, has been identified as possibly being responsible for the observed abundance pattern found in certain carbon-enhanced metal-poor (CEMP) stars. The production site may be low-metallicity stars on the asymptotic giant branch (AGB) where the physical processes during the thermal pulses are not well known.

Aims.We investigate the impact of overshoot from various convective boundaries during the AGB phase on proton ingestion events (PIEs) and the neutron densities as a necessary precondition for thei-process as well as on the structure and continued evolution of the models.

Methods.We therefore analyzed models of a 1.2 M⊙,Z = 5 × 10−5star. A fiducial model without overshoot on the AGB (overshoot was applied during the pre-AGB evolution) serves as a reference. The same model was then run with various overshoot values and the resulting models were compared to one another. Light element nucleosynthesis is also discussed. Additionally, we introduce a new timescale argument to predict PIE occurrence to discriminate between a physical and a numerical reason for a nonoccurrence. A comparison to observations as well as previous studies was conducted before finally presenting the most promising choice of overshoot parameters for the occurrence of thei-process in low-mass, low-metallicity models.

Results.The fiducial model reveals high neutron densities and a persistent split of the pulse-driven convection zone (PDCZ). Overshoot from the PDCZ results in either temporary or permanent remerging of the split PDCZ, influencing the star’s structure and evolution. While both overshoot and non-overshoot models exhibit PIEs generating neutron densities suitable for thei-process, they lead to varied C/O and N/O ratios and notable Li enhancements. Comparison with previous studies and observations of CEMP-r/s stars suggests that while surface enhancements in our models may be exaggerated, abundance ratios align well. Though, for high values of overshoot from the PDCZ the agreement becomes worse.
Nonlinear asymptotic mean value characterizations of holomorphic functions
Authors: Durastanti Riccardo , Magnanini Rolando
Published: April 2024

Starting from a characterization of holomorphic functions in terms of a suitable mean value property, we build some nonlinear asymptotic characterizations for complex-valued solutions of certain nonlinear systems, which have to do with the classical Cauchy-Riemann equations. From these asymptotic characterizations, we derive suitable asymptotic mean value properties, which are used to construct appropriate vectorial dynamical programming principles. The aim is to construct approximation schemes for the so-called contact solutions, recently introduced by N. Katzourakis, of the nonlinear systems here considered.
CAR-T-Zell-Therapie bei autoimmunen Erkrankungen
Authors: Pecher Ann-Christin , Henes Jörg
Published: April 2024

Chimeric-Antigen-Receptor(CAR)-T-Zellen haben das Feld der Hämato-Onkologie revolutioniert und kommen seit 2021 auch im Bereich der Autoimmunerkrankungen zur Anwendung. Patienteneigene T-Zellen werden mit einem künstlich hergestellten T-Zell-Rezeptor („CAR“) transfiziert, woraufhin diese den B-Zell-Marker CD19 (oder auch andere Oberflächenmarker) erkennen. Nach Rückgabe der modifizierten T-Zellen nach erfolgter lymphodepletierender Chemotherapie kommt es zu einer raschen Expansion der CAR-T-Zellen. Diese ist mit potenziellen typischen Komplikationen wie dem Cytokine-Release-Syndrome und Immune-Effector-Cell-Associated-Neurotoxicity-Syndrome assoziiert. Die Wirkweise der CAR-T-Zell-Therapie ist noch nicht endgültig erklärt. Das verbesserte Ansprechen von Patienten wird aufgrund des weitverbreiteten Markers CD19 sowie des zellulären Elements der CAR-T-Zellen erklärt. Bislang existieren nur Fallberichte/-serien. Die Erfolge müssen sich nun in klinischen Studien – welche weltweit anlaufen – bestätigen.
Neue Ansätze in der immunologischen Therapie der Riesenzellarteriitis und Polymyalgia rheumatica
Authors: Petzinna Simon M. , Schäfer Valentin S.
Published: April 2024

Die Riesenzellarteriitis (RZA) ist eine Autoimmunerkrankung der großen und mittelgroßen Arterien. Sie ist die häufigste primäre systemische Vaskulitis in der westlichen Welt. Eine verzögerte Diagnose kann schwerwiegende Komplikationen wie permanenten Sehverlust zur Folge haben. Der vaskuläre Ultraschall hat sich als schnelle und zuverlässige Methode in der Diagnostik der RZA etabliert. Pathophysiologisch zeigt sich ein Zusammenspiel des angeborenen und adaptiven Immunsystems. Eine häufige Assoziation besteht mit der Polymyalgia rheumatica (PMR). Bei Verdacht auf RZA ist eine sofortige Glukokortikoid-Stoßtherapie, gefolgt von einem Tapering zumeist über 6 Monate, indiziert. Tocilizumab, ein Inhibitor des IL-6-Rezeptors, hat sich als therapeutischer Goldstandard zur Reduktion der kumulativen Steroid-Dosis und Rezidivrate der RZA etabliert. Bei der Behandlung der PMR werden primär Glukokortikoide eingesetzt, wobei ein Tapering über mindestens 1 Jahr empfohlen wird. Bei hohem Risiko für ein Rezidiv kann zusätzlich die Gabe von Methotrexat oder Tocilizumab in Betracht gezogen werden. Derzeit befinden sich zahlreiche Therapieansätze zur Behandlung von RZA und PMR in klinischen Studien.
Editorial
Authors: Meyer Nora , Schacher Ben , Abend Annika , Maegele Marc
Published: April 2024

Liebe Lesende,

in unserem Arbeitsalltag begegnen uns eine Vielzahl verschiedener Patient*innen. Was
diese verbindet, sind ihre Einschränkungen der oberen Extremität, auf die wir als
medizinische und therapeutische Expert*innen spezialisiert sind. Trotzdem sollten
die physischen Verletzungen selten isoliert betrachtet werden, da die Hand keine
Maschine ist, die allein durch eine rein funktionelle Behandlung „repariert“ und
wieder zum Einsatz gebracht werden kann. Der Mensch, der hinter einer Diagnose
steht, wirkt mit allem, was ihn ausmacht, bei seinem Heilungsprozess mit. Mit dieser
Ausgabe wollen wir Ihnen ein wichtiges Thema näherbringen, das zur täglichen
handtherapeutischen Praxis gehört: psychologische Aspekte bei der Arbeit mit
Patient*innen.
Schmerz lass nach: Eine Einführung in die moderne
Schmerztherapie
Authors: Jansen Jan-Peter
Published: April 2024

Schmerz ist eine unangenehme emotionale Empfindung assoziiert mit einer
tatsächlichen oder potentiellen Gewebeschädigung. Dabei handelt es sich immer um
eine individuelle Erfahrung, die körperliche, psychologische und soziale
Faktoren umfasst. Das Phänomen Schmerz ist nicht identisch mit der bloßen
Aktivierung von Nervenzellen durch potentiell schädigende Einflüsse wie
beispielsweise Hitze, chemische Stoffe, Verletzung, oder Sauerstoffmangel,
sondern wird während des Lebens durch Erfahrungen erlernt.
Temporary disability pension recipients: Contextual stress factors
and their effect on return-to-work-intention
Authors: Savvoulidou Dimitra , Kröger Christoph , Kobelt-Pönicke Axel
Published: April 2024

Background and purpose In the last decades, Germany has experienced a vast
increase in the number of individuals applying for or receiving disability
benefit. Only a small proportion of them intends to return to work. The present
study aims to identify and describe the percentage of temporary disability
pensioners, who have the intention to return to working life.

Methods The final sample consisted of 496 insured individuals who were
receiving temporary disability pension from the Regional German Pension
Insurance (DRV) at that time. Participation was voluntary and anonymous. The
following self-report instruments were administered: a. Evaluation of Contextual
Factors; b. German Symptom Validation Test (BEVA); c. German Patient Health
Questionnaire (PHQ-9); d. Readiness for Return-to-Work German Scale (RRTW).

Results The results revealed that approximately 6% of participants were at
the stage of “preparation”, 31.9% at the stage of “contemplation”, and more than
half of the participants were at the stage of “pre-contemplation” according to
the RRTW. Comparing the groups of “pre-contemplation” (Group 1) and
“contemplation+preparation” (Group 2+3), no statistically significant
differences were found, except for age.

Conclusions In conclusion, further research is required to identify
possible factors which could predict the stage of RRTW. New interventions are
needed that can raise the motivation for and success in the return to work of
disability pensioners.
Abgrenzung und Stressabbau in der therapeutischen
Praxis
Authors: Negi Tatjana
Published: April 2024

Ergo- und Physiotherapeut*innen sowie medizinisches Fachpersonal sind täglich mit
vielen Menschen im Kontakt. Dazu gehören auch Patient*innen und Mitarbeitende,
die sie als herausfordernd oder stressig empfinden. Wie Sie damit umgehen, liegt
aber nicht nur am Verhalten der anderen Person. Um gelassen auf anstrengende
Situationen reagieren zu können, brauchen Sie eine bewusste Stressregulation. Im
Folgenden werden Übungen für therapeutisches Fachpersonal vorgestellt, die Ihnen
dabei helfen.
Liebe Leserinnen, liebe Leser,
Authors: Buschmann-Steinhage Rolf
Published: April 2024

wenn Sie diese Ausgabe unserer Zeitschrift in Händen halten, entsteht ein Aktionsplan
für ein diverses, inklusives und barrierefreies Gesundheitswesen. Der
Koalitionsvertrag „Mehr Fortschritt wagen“ der aktuellen Bundesregierung sah die
Erarbeitung dieses Aktionsplans bis Ende 2022 vor. Aber erst am 18. Oktober 2023
begann das Bundesgesundheitsministerium (BMG) mit einer Auftaktveranstaltung einen
schriftlichen Beteiligungsprozess. Bis zum 15. Dezember 2023 konnten sich alle
relevanten Akteure mit Vorschlägen für Maßnahmen an das BMG wenden. Obwohl der
Beteiligungsprozess nicht barrierefrei war, kam es so zu rund 3.000 Vorschlägen, die
vom BMG zu rund 1.300 Vorschlägen zusammengefasst wurden. Das Arbeitsdokument dazu
hat 483 Seiten. Seit Ende Februar finden nun zu sieben Themenfeldern je zwei
Fachgespräche statt und schon im Sommer soll der Aktionsplan vorliegen. Spannend
wird sein, welche Vorschläge es letztlich in den Aktionsplan schaffen und vor allem,
welche dann auch umgesetzt werden.
Ultraschalluntersuchungen in der Kinderrheumatologie
Authors: Roth Johannes , Windschall Daniel
Published: April 2024

Das kindliche Handgelenk und die Fingergelenke zeigen eine hohe anatomische Komplexität mit der Möglichkeit einer Pathologie im Bereich zahlreicher synovialer Rezessus, aber auch der verschiedenen Sehnenscheiden, des Paratenons und vieler verschiedener Enthesen, insbesondere im Bereich der Finger. Die Sicherheit und Genauigkeit bei der Diagnosestellung einer rheumatischen Entzündung profitiert deshalb wesentlich vom Ultraschall in Ergänzung zum klinischen Befund. Mehrere Studien der letzten Jahre konnten für diese Region die Überlegenheit des Ultraschalls versus klinischer Untersuchung nachweisen. Mit zunehmendem Einsatz des Gelenkultraschalls verbessern sich die diagnostischen Möglichkeiten bei der Diagnosestellung, Abgrenzung und im Verlaufsmonitoring kindlich rheumatischer Erkrankungen. Wichtige Differenzialdiagnosen können sonografisch ausgeschlossen oder bestätigt werden. Zunehmende Standards helfen bei der praktischen Durchführung, Beurteilung und Quantifizierung des pathologischen Befundes.
Herausforderungen einer bedarfsorientierten Reha-Steuerung nach
Oberschenkelamputation
Authors: Egen Christoph , Schiller Jörg , Ernst Jennifer , Sturm Christian , Eckhardt Isabelle
Published: April 2024

Im internationalen Kontext wird unter Rehabilitation eine Gesundheitsstrategie
verstanden 1, die durch verschiedene Maßnahmen
auf verbesserte Funktionsfähigkeit zielt, um Teilhabeeinschränkungen zu reduzieren,
die Menschen mit gesundheitlichen Beeinträchtigungen in der gesellschaftlichen
Interaktion erfahren 2. Die aktuelle Resolution
der Weltgesundheitsversammlung „Strengthening rehabilitation in health systems”
3 fordert in Übereinstimmung mit der
UN-Behindertenkonvention 4, dass für die
medizinischen Belange von Menschen mit Beeinträchtigungen adäquate
Rehabilitationsdienste und Rehabilitationsprogramme zur Verfügung stehen müssen.
Dies entspricht dem Prinzip einer bedarfsorientierten Leistungserbringung ohne
Limitierung durch den Grad der Beeinträchtigung einer Person. Darüber hinaus
sollen in allen Phasen der Gesundheitsversorgung diese Rehabilitationsdienste
verfügbar sein, also vom Akutkrankenhaus bis zur Langzeitversorgung.
Enterovirus Infection in Preterm Quadruplets with Clinical
Presentation of Neonatal Late-Onset Sepsis: a Case Report
Authors: Seifert Viktor , Böck Lena , Wirbelauer Johannes
Published: April 2024

This is the unusual case of concurrent late-onset sepsis caused by enteroviruses
in preterm quadruplets in a neonatal ward. While viral infections are an
important differential diagnosis of bacterial sepsis in the outpatient setting,
the occurrence in a neonatal ward with strict prophylactic hygiene measures is
unusual. In this case, transmission of enteroviruses via breast milk appears
possible.
Auswirkungsanalyse einer neuen, sektorenübergreifenden Erbringung bisher stationärer endoskopischer gastroenterologischer Leistungen entsprechend §115f SGB
V (Hybrid-DRG): Zuordnungsmatrix und Kostenanalyse
Authors: Rathmayer Markus , Belle Sebastian , Heinlein Wolfgang , Dollhopf Markus , Braun Martin , Albert Jörg G.
Published: April 2024

Hintergrund Mit Einführung des §115f SGB V ist die Voraussetzung für eine „spezielle sektorengleiche Vergütung“ (‚Hybrid-DRG‘) geschaffen. In einer Auswirkungsanalyse haben wir bisher stationäre Gastroenterologisch-endoskopische (GAEN)-Fälle in einer Matrix der zukünftigen Hybrid-DRG vs. dem ambulanten Operieren (AOP) oder einer stationären Behandlung zugeordnet.

Methoden In ausgewählten DRGs (G47B, G67A, G67B, G67C, G71Z, H41D, H41E) wurde eine Zuordnungsmatrix von GAEN-Fällen medizinisch begründet erstellt. Leistungsgruppen des DGVS-Leistungskatalogs wurden hierfür durch eine Expertengruppe anhand des Positionspapiers der DGVS den Gruppen Hybrid-DRG, AOP und Stationär zugeordnet. Kostendaten aus dem DGVS-DRG-Projekt des Datenjahres 2022 aus 36 InEK-Kalkulationskrankenhäusern mit insgesamt 232.476 GAEN-Fällen wurden ausgewertet.

Ergebnisse 26 Leistungsgruppen des DGVS-Leistungskatalogs wurden der Gruppe „Hybrid-DRG“, 24 der Gruppe „stationär“, 12 der Gruppe „AOP“ zugeordnet. 7 Leistungsgruppen wurden „abhängig vom OPS-Kode“ gesplittet und auf dieser Ebene eingestuft. Fälle mit Zusatzentgelten wurden von einer Hybrid-DRG ausgeschlossen, da diese dort nicht vereinbart werden können.

Die Kostenanalyse zeigt, dass Leistungen, die bereits im AOP sind, ein ähnliches Kostenniveau haben, wie Leistungen, die als „Hybrid-DRG“ eingestuft wurden. Mit der Kostenkalkulation konnte für die gebildeten Hybrid-DRG ein Kostenniveau dargestellt werden.

Schlussfolgerung Auf Basis von klar definierten strukturellen, prozeduralen und personellen Voraussetzungen können Leistungen aus geeigneten DRGs in eine Hybrid-DRG überführt werden. Eine Zuordnung von Leistungen ohne die Einbeziehung von Fachexperten erscheint dabei äußerst schwierig. Die Fallzuordnung anhand willkürlicher Kontextfaktoren erhöht die Komplexität, ohne die Qualität der Zuordnung nachweislich zu erhöhen und müssen weiterentwickelt werden. Eine Kostenanalyse kann aus den bekannten stationären Kosten abgeleitet werden und muss als Grundlage für den Hybrid-DRG-Katalog 2025 dienen.
Clinical Pathways and Outcomes of Andexanet Alfa Administration for the Reversal of Critical Bleeding in Patients on Oral Direct Factor Xa Inhibitors
Authors: Goldin Mark , Smith Kolton , Koulas Ioannis , Leung Tungming , Ravi Mayuri , Parhar Sanjit , Shah Sejal , Floyd Kayla , Ohanesian Lori , Bain Rachel , Defonte Daniella , Ochani Kanta , Lin Amanda , Patel Bhumi , Tsaftaridis Nikolaos , Jnani Jack , Spyropoulos Alex C.
Published: April 2024

Background Andexanet is U.S. Food and Drug Administration (FDA) approved for the reversal of critical bleeding from factor Xa inhibitors and off-label for surgical reversal. Data are lacking on andexanet administration processes.

Methods We retrospectively studied patients at a 23-hospital system who received andexanet from November 2019 to March 2023. Abstractors coded demographics, comorbidities, anticoagulant use, andexanet indication, and process times. The primary outcome was presentation-to-andexanet time; diagnosis, ordering, and administration times were calculated. Secondary outcomes included in-hospital postandexanet major thromboembolism/bleeding and mortality.

Results In total, 141 patients were analyzed. Andexanet indications were predominantly neurologic bleeding (85.8%). Twenty-four patients (17.0%) were transferred from nontertiary/academic centers to tertiary/academic centers. The median presentation-to-administration time was 192.5 minutes (interquartile range [IQR]: 108.0–337.0 minutes). Components were as follows: 72.5 minutes (IQR: 39.0–137.5 minutes) for bleeding diagnosis; 35.5 minutes (IQR: 0–96.5 minutes) for andexanet ordering; and 53.0 minutes (IQR: 38.5–78.5 minutes) for administration, which was longer at tertiary/academic hospitals (ratio 1.5, 95% confidence interval [CI]: 1.2–2.0, p = 0.002). Gastrointestinal or other critical bleeding (ratio 2.59, 95% CI: 1.67–4.02, p < 0.001), and tertiary/academic center treatment (ratio 1.58, 95% CI: 1.15–2.18, p = 0.005), were associated with increased time. Major thromboembolism, bleeding, and mortality occurred in 10.6, 12.0, and 22.9% of patients, respectively.

Conclusions In our cohort, the median presentation-to-administration time was over 3 hours. Cumulative times were longer at tertiary/academic hospitals and for gastrointestinal/other bleeding. Postandexanet major thromboembolism/bleeding occurred more at tertiary/academic hospitals, possibly related to transfers. Prospective studies may elucidate clinical decision-making bottlenecks.