bluuebunny/crossref_metadata_2025 huggingface dataset:
IMPLEMENTATION OF ACADEMIC SUPERVISION OF ISLAMIC RELIGIOUS EDUCATION DURING THE COVID-19 PANDEMIC
Authors: Suhairi Suhairi , Badrudin Badrudin
Published: December 2021

This study aims to analyze the implementation of academic supervision of Islamic Religious Education supervisors during the covid-19 pandemic at the Ogan Komering Ulu Selatan District Public Middle School. The approach used is descriptive qualitative—data collection through observation, interview, and documentation techniques. The data analysis technique is carried out circularly, starting from data reduction, data display, and conclusion drawing is a data analysis technique carried out. The results showed that the implementation of the academic supervision of the Islamic Religious Education supervisor during the Covid-19 pandemic at the Ogan Komering Ulu Selatan District Public Middle School was carried out online and offline with individual and group techniques. The implementation of academic supervision carried out are activities for fostering Islamic Religious Education (GPAI) teachers, monitoring National Education Standards (SNP), evaluating PAI teacher performance, and carrying out professional guidance and training for PAI teachers. It's just that these activities have not run optimally.
Effects of magnetic stimulation compared to electrical stimulation on muscle contraction in quadriceps femoris muscle of healthy subjects: A pilot study
Authors:   Department of Rehabilitation Science, Kobe University Graduate School of Health Sciences, Kobe, Japan., Nakanishi Ryosuke , Tanaka Minoru ,   Department of Rehabilitation Science, Osaka Health Science University, Osaka, Japan., Maeshige Noriaki ,   Department of Rehabilitation Science, Kobe University Graduate School of Health Sciences, Kobe, Japan., Fujino Hidemi ,   Department of Rehabilitation Science, Kobe University Graduate School of Health Sciences, Kobe, Japan.
Published: December 2021

Background/Aims: This study investigated whether pulsed magnetic stimulation contracts superficial and/or deep muscles compared with those induced by electrical stimulations, i.e., low- and kilohertzfrequency currents. Methods: Eight healthy subjects were recruited and measured the quadriceps femoris muscle thickness using ultrasound imaging, and Visual Analog Scale (VAS) for stimulation-induced pain during the same stimulation intensity. Results: Pulsed magnetic stimulation increased the thickness of rectus femoris muscle similar to other electrical stimulations, but not the vastus intermedius muscle. Meanwhile, the pain score of VAS caused by pulsed magnetic stimulation was lower than that by those electrical stimulations. Conclusions: These results suggest that pulsed magnetic stimulation is effective for the contraction of superficial layer muscles without stimulation-induced pain but not for contraction of deep layer muscles. Keywords: pulsed magnetic stimulation; electrical stimulation; stimulation-induced pain; muscle contraction.
Incarcerated intrapericardial diaphragmatic hernia after laparoscopic pericardial window for malignant pericardial effusion
Authors:   Department of Thoraco-Abdominal Surgery, AZ Sint-Blasius, Dendermonde, Belgium., Bardisi Ekhlas S , Redmer Luning ,   Department of Thoraco-Abdominal Surgery, AZ Sint-Blasius, Dendermonde, Belgium., Verlaeckt Luk ,   Department of Thoraco-Abdominal Surgery, AZ Sint-Blasius, Dendermonde, Belgium., Vanrykel Filip ,   Department of Thoraco-Abdominal Surgery, AZ Sint-Blasius, Dendermonde, Belgium.
Published: December 2021

Laparoscopic Pericardial Window (LPW) is a safe, minimally invasive surgical technique for treating pericardial effusion/tamponade. This technique allows adequate decompression and avoids single-lung ventilation and the need for thoracic drainage in severely ill patients; it also provides anatomopathological and microbiological diagnosis leading to treatment measures. An intrapericardial diaphragmatic hernia is among the rarest complications of this procedure. A 85-year-old man, who underwent LPW for pericardial tamponade, presented to the emergency department 12 days post-operative with bowel obstruction; CT scan showed an incarcerated hernia into the pericardial sac. Laparoscopic reduction and hernia repair were performed using a large-pore Mesh to allow further drainage of histologically proven malignant pericardial effusion. Keywords: pericardial tamponade; pericardial window; surgical drainage of pericardial effusion; intra-pericardial diaphragmatic hernia.
Breaks, bends and holes
Authors:   Department of Pediatrics, Yenepoya medical College, University Road, Deralakatte, Mangalore 575018, India., Suhara Safeena Ansari , KS Sahana ,   Department of Pediatrics, Yenepoya medical College, University Road, Deralakatte, Mangalore 575018, India., Keshav Sushma ,   Department of Pediatrics, Yenepoya medical College, University Road, Deralakatte, Mangalore 575018, India., Saldanha Prakash ,   Department of Pediatrics, Yenepoya medical College, University Road, Deralakatte, Mangalore 575018, India., Shirodkar Diksha ,   Department of Pediatrics, Yenepoya medical College, University Road, Deralakatte, Mangalore 575018, India.
Published: December 2021

A 14 year old boy presented with lower limb deformities and bone pain since 8 months. He was severely wasted, stunted with tachypnea, pallor, genu-valgum, widened wrists and rachitic rosary. Workup revealed end-stage-renal-disease with metabolic acidosis, anaemia, hypocalcemia and secondary hyperparathyroidism. Scannogram of both lower limbs showed evidence of rickets, fractures and a lytic lesion in the lower end of the right femur suggestive of osteitis-fibrosa-cystica (OFC). The case depicts how one should evaluate a lytic bony lesion taking into consideration the complete clinical and biochemical picture and that OFC is not uncommon in adolescence in the presence of unchecked hyperparathyroidism. The child was treated with iron therapy, oral bicarbonate, oral vitamin D, erythropoietin and advised renal replacement therapy.
Sturge-weber syndrome: Characteristics of facial port wine stain with neurological and ophthalmological deficits
Authors:   Department of Dermatology and Venereology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada/ Dr. Sardjito Hospital, Yogyakarta, Indonesia., Putra Prasta Bayu , Danarti Retno ,   Department of Dermatology and Venereology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada/ Dr. Sardjito Hospital, Yogyakarta, Indonesia.
Published: December 2021

Background: Sturge-Weber Syndrome (SWS) is a neurocutaneous defect involving facial Port Wine Stain (PWS) with vascular deficits in the brain and ipsilateral eyes. Facial PWS can be the initial marker and help predict the severity of SWS. Aims and objectives: To study the association of facial PWS characteristics, neurological and ophthalmological deficits in SWS with the degree of severity. Materials and Methods: A retrospective descriptive study of patients with SWS was conducted at Dr. Sardjito Hospital between January 2010 - December 2020. Facial PWS characteristics were assessed from photographs. Assessments of neurological and ophthalmological deficits used physical and supportive examinations, including Electroencephalogram (EEG), Magnetic Resonance Imaging (MRI), and Intelligent-Quotient (IQ). Results: From 19 female patients aged 1 month to 26 years with facial PWS, seven fulfilled the inclusion criteria. “High risk” facial PWS V1 and P1 b distribution patterns were found in all patients. Most patients had neurological deficits of rare focal seizures (83%). Fine motor disorders (50%) were the most severe motoric deficits found. All patients experienced glaucoma with decreased visuality to blindness and hemianopsia. EEG epileptiform patterns, MRI showing angiomatosis and brain atrophy, and low IQ scores were recorded. Conclusions: Pathogenesis and degree of severity in SWS were related to facial PWS, neurological and ophthalmological deficits. Keywords: Sturge-weber syndrome; facial port-wine stain; neurological deficit; ophthalmological deficit; neurocutaneous disorder.
Pleomorphic adenoma of the palate
Authors:   Department of Otorhinolaryngology, Head and Neck Surgery at “Fattouma Bourguiba” Hospital, Monastir, Tunisia., Kolsi Naourez , Bergaoui Emna ,   Department of Otorhinolaryngology, Head and Neck Surgery at “Fattouma Bourguiba” Hospital, Monastir, Tunisia., Bouatay Rachida ,   Department of Otorhinolaryngology, Head and Neck Surgery at “Fattouma Bourguiba” Hospital, Monastir, Tunisia., Koubaa Jamel ,   Department of Otorhinolaryngology, Head and Neck Surgery at “Fattouma Bourguiba” Hospital, Monastir, Tunisia.
Published: December 2021

A woman 43 years, presented with 9 years history of a painless swelling in the palatal region, slow-growing. Her medical history was not significant. On intraoral examination, a median ovoid mass measuring 4 cm diameter was found at the junction of hard and soft palate. The mass was firm, with smooth surface. No radiographic evidence of bone involvement was seen on the CT scan (Figure A). Surgical excision under general anesthesia: excision of the mass was carried out, the overlying mucosa was healthy, so conserved (Figure B,C&D). Histopathologic report confirmed the lesion to be “pleomorphic adenoma”. The lesion has not recurred after four years follow-up.
Inflammatory bowel disease and COVID-19: A review
Authors:   Department of Gastroenterology, Tribhuvan University Teaching Hospital, Kathmandu, Nepal., Hamal Rabin , Pathak Rahul ,   Department of Gastroenterology, Tribhuvan University Teaching Hospital, Kathmandu, Nepal., Kafle Bhandari Brindeswari ,   Department of Gastroenterology, Tribhuvan University Teaching Hospital, Kathmandu, Nepal., Jha Anurag ,   Department of Gastroenterology, Tribhuvan University Teaching Hospital, Kathmandu, Nepal., Gnawali Arun ,   Department of Gastroenterology, Tribhuvan University Teaching Hospital, Kathmandu, Nepal., Koirala Dinesh ,   Department of Gastroenterology, Tribhuvan University Teaching Hospital, Kathmandu, Nepal., Bhusal Mohan ,   Department of Gastroenterology, Tribhuvan University Teaching Hospital, Kathmandu, Nepal., Sharma Sashi ,   Department of Gastroenterology, Tribhuvan University Teaching Hospital, Kathmandu, Nepal.
Published: December 2021

The World Health Organization officially declared infection with severe acute respiratory syndrome coronavirus 2 (SARSCoV-2), leading to coronavirus disease 2019 (COVID-19) as a Public Health Emergency of International Concern (PHEIC) on 30 January 2020 and then as a pandemic on March 11, 2020 with reports of infection from most of the countries of the world [1]. COVID-19 has severely disrupted prevention and treatment for noncommunicable diseases. Severe illness can occur in otherwise healthy individuals of any age, but it predominantly occurs in adults with advanced age or certain underlying medical comorbidities [2]. Since the beginning of the health emergency, particular attention has been paid to the management of patients with chronic Inflammatory Bowel Diseases (IBDs) because they frequently are treated with immunosuppressive drugs and therefore potentially are exposed to a greater infectious risk than the general population [3].
Remarks on patients with traumatic brain injury due to traffic accident related to alcohol comsumption treated in Vietduc hospital after implementing the decree 100
Authors:   Viet Duc University Hospital, Vietnam., Chinh Nguyen Duc
Published: December 2021

Purpose: Traumatic Brain Injury (TBI) is still considered as a leading cause of morbidity and mortality of victims by traffic accident. Despite a fact that many measurements and preventions have been applied, the rate of TBI is remained high. Aim of this study was to investigate treatment process of TBI caused by road traffic accident at Viet Duc Hospital after the Decree 100 which has been issued in Vietnam in early 2020. Materials and method: A retrospective and prospective study has been conducted in Viet Duc Hospital from Dec, 2020 to March, 2021. All the patients with TBI by road traffic accident were enrolled. Severity of TBI was identified by Glasgow Scale (GCS) and BAC (Blood Alcohol Concentration) test taken on arrival. The data was collected from medical record as well as autopsy report and analysed by SPSS.20.0 Results: A total of 150 patients with TBI by road traffic accidents were enrolled, age group from 21 to 60 years old accounted for 64%, male accounted for 86.7%. Associated injuries were maxillofacial lesions 48%, extremities 24.7%, chest accounted for 20%. Severity of TBI with GCS 6 - 8 was the highest rate 52%, from 3 - 5 GCS accounted for 30%. 40% were operated on emergency; BAC was positive 46.7%, of which over from 50 mg/L accounted for 32.6%. The patients with GCS from 6 to 8 were BAC positive accounted for a higher rate than groups with GCS above 9 or below 5. The most common TBI lesions were subarachnoid hemorrhage, subdural hematoma and cerebral edema accounted for 67.3%, 60% and 58% respectively. Overall mortality was 26% including in-hospital death and discharged to die. Conclusions and recommendations: Data from the study has shown that many young men with severe TBI by road traffic accident were BAC positive which can results in the high risk of death and disability. Thus, we highly recommend counterparts should constantly strengthen the propaganda and enforcement measures in order to reduce traffic accidents and TBI patients. Keywords: traffic accidents; injury; brain trauma severity.
Suspected Down Syndrome in one of non-identical twins in Ile-Ife: A case report
Authors:   Department of Obstetrics, Gynaecology, and Perinatology, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Osun state, Nigeria., Eseme Ubom Akaninyene
Published: December 2021

Nigerian women of southwest extraction have the highest rate of dizygotic twinning worldwide, with a reported incidence as high as 49 per 1000 deliveries. Among the risk factors for dizygotic twinning is advanced maternal age, which is also an independent risk factor for Down syndrome (trisomy 21). Down syndrome is the most common chromosomal disorder affecting live born neonates. It occurs very rarely in twins, seen in 14-15 per million non-identical twins. Down syndrome in one of non-identical twins was first reported in Nigeria by Otaigbe in Port Harcourt, in 2007. Herein, we report another case of suspected Down syndrome in one of non-identical twins born to a 41-year-old grand multiparous woman at the Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Osun state, Nigeria. Keywords: Down Syndrome; dizygotic; fraternal; dichorionic; diamniotic.
Primary Herpes Simplex viral infection of bilateral nipples and areolae with reactive arthritis: An uncommon presentation of a common disease
Authors:   Acting Consultant Dermatologist, Teaching Hospital, Batticaloa, Sri Lanka., B Thanushah , N Thamilvannan ,   Consultant Dermatologist, Teaching Hospital, Batticaloa, Sri Lanka., M Ahilen ,   Consultant Physician, Teaching Hospital, Batticaloa, Sri Lanka., S Ahilan ,   Consultant Histopathologist, Teaching Hospital, Batticaloa, Sri Lanka., SH Chandrarathna ,   Registrar in Dermatology, Teaching Hospital, Batticaloa.
Published: December 2021

Herpes Simplex Viruses (HSV) are members of the Herpesvirales, subfamily Alphaherpesvirinae. They are linear double standard DNA viruses. Skin manifestations caused by HSV is one of the commonest cutaneous infectious diseases encountered during dermatology practice. It affects most people on one or more occasions during their lives. Cutaneous presentations are characterized by painful localized grouped vesicles. Type 1 HSV is mainly associated with orofacial involvement. Type 2 HSV is mainly associated with anorectal involvement. However, HSV infection can occur almost any area of skin or mucous membrane.
Deteriorating cardiac function in patients with chronic total occlusion after successful percutaneous coronary intervention: A case series
Authors:   Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China, 100029., Yang Xueyao , Tian Jinfan ,   Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China, 100029., Popal Mohammad Sharif ,   Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China, 100029., Zhang Lijun ,   Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China, 100029., He Yi ,   Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China, 100050., Song Xiantao ,   Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China, 100029.
Published: December 2021

Background: Current trials show conflicting results about the effect of successful Percutaneous Coronary Intervention (PCI) on cardiac function in patients with chronic total occlusion (CTO). Various factors contribute to a lack of functional changes after CTO revascularization. Case summary: Here, we present three patients who underwent PCI to treat CTO of the single main branch, all of whom demonstrated a decline in cardiac function detected by Cardiovascular Magnetic Resonance (CMR). Case 1 is a patient with a history of smoking, and transmural myocardial necrosis in the territory of the CTO at baseline. Case 2 exhibites hyperglycemia and persistent ischemia in a non-CTO-supplied territory. Case 3 has a long history of alcohol abuse, likely causing adverse ventricle remodeling after PCI. Discussion: The deterioration observed in these cases does not appear to be associated with the PCI itself. It should be considered that postoperative risk factors attenuate the true benefits of CTO revascularization. This case series also highlights the prudent selection of patients eligible for revascularization by comprehensive assessments and recommends continuous strict management during follow-up to improve the long-term prognosis of patients and the application value of CTO revascularization. Keywords: chronic total occlusion; percutaneous coronary intervention; cardiac function; adverse ventricle remodeling; cardiovascular magnetic resonance imaging
Cysticercotic fourth ventricle ependymitis
Authors:   Department of Neurodegenerative Disorders, Instituto Nacional de Ciencias Neurológicas, Peru., Cosentino Carlos , Vélez Miriam ,   Department of Neurodegenerative Disorders, Instituto Nacional de Ciencias Neurológicas, Peru., Torres Luis ,   Department of Neurodegenerative Disorders, Instituto Nacional de Ciencias Neurológicas, Peru.
Published: December 2021

Neurocysticercosis is endemic in many regions of the world. Extra parenchymal forms of neurocysticercosis are infrequent but may be associated with hydrocephalus. We report the case and show a typical MRI of fourth ventricle ependymitis caused by cysticercosis. Keywords: ependymitis; cysticercosis.
Type A aortic dissection in a young 37 weeks pregnant lady successfully treated by Bentall procedure: A case report
Authors:   Punjab Institute of Cardiology, Lahore, Pakistan., Shahid Rehan , Izhar Adnan ,   Punjab Institute of Cardiology, Lahore, Pakistan., Husnain Ali ,   King Edward Medical University, Lahore, Pakistan., Sohail Anum ,   King Edward Medical University, Lahore, Pakistan., Umar Hassan Muhammad ,   King Edward Medical University, Lahore, Pakistan., Mushtaq Maham ,   King Edward Medical University, Lahore, Pakistan., Liaqat Ch Faizan ,   Ameer ud din Medical College, Lahore, Pakistan.
Published: December 2021

Aortic dissection is intimal tear in aorta and collection of blood in between the layers of aortic wall. The incidence of acute type A aortic dissection is between 2.1 and 16.3 per 100,000 persons [1]. Aortic dissection is an infrequent but potentially life threatening complication of pregnancy with most of the cases occurring in third trimester and post-partum period [2]. The most important predisposing factors to aortic dissection are Marfan, Ehlers-Danlos, Turner and Loeys-Dietz syndromes [3]. However, the non sporadic cases can also occur in pregnancy [4].
Disparitas Harga Pangan Strategis Sebelum dan Saat Pandemi COVID-19
Authors: Firdaus Muhammad
Published: December 2021

This study aims to compare the variability and convergence of strategic food prices before and during the COVID-19 pandemic in Indonesia. The weekly prices data of 9 food commodities in 34 provinces during 2019 and 2020 was used. The price variability and convergence are analyzed using the coefficient of variation and dynamic data panel, respectively. The result showed that the rice, beef, red chilies, chicken meat, and chicken eggs experienced a decrease in price variability while sugar, shallots, garlic, and cayenne pepper exhibited the opposite. Prices movement among regions tends to show increasing price variability, with the exception of chicken eggs. Some efforts such as supply management through structuring production over time, efficiency of distribution between regions is imperative to stabilize food prices. Besides, efforts such as a market contract system, warehouse receipt systems and strengthening Local Government-Owned Enterprise for food supply management are crucial.Keywords: horticulture; convergence; dynamic panel data; variability

AbstrakPenelitian ini bertujuan untuk membandingkan variabilitas dan konvergensi harga pangan strategis sebelum dan selama pandemi COVID-19 di Indonesia. Data yang digunakan adalah harga mingguan 9 komoditas pangan di 34 provinsi selama 2019 dan 2020. Variabilitas dan konvergensi harga dianalisis menggunakan koefisien variasi dan data panel dinamis. Hasil penelitian menunjukkan bahwa beras, daging sapi, cabai merah, daging ayam, dan telur ayam mengalami penurunan variabilitas harga, sedangkan gula, bawang merah,bawang putih, dan cabai rawit mengalami sebaliknya. Pergerakan harga antar wilayah menunjukkan variabilitas harga yang cenderung meningkat, kecuali harga telur ayam. Beberapa hal yang dapat dilakukan untuk menstabilkan harga pangan adalah manajemen pasokan melalui penataan produksi antar waktu dan efisiensi distribusi antar daerah. Selain itu, sistem kontrak pemasaran, sistem resi gudang, dan penguatan Badan Usaha Milik Daerah untuk pengelolaan pasokan makanan sangatlah penting.
Hz. Peygamber’in (s.a.v.) Üslubu ve Anlatım Tarzı
Authors: ASLAN Recep
Published: December 2021

Edebî yönden eşsiz olan Kur’an-ı Kerîm’in mesajını insanlığa bildiren Hz. Peygamber (s.a.v.), Arap dilinin anlatım olanaklarından faydalanmış ve edebî bir üslup kullanmıştır. İfadelerinde fazlasıyla edebî tabirler bulunan Hz. Peygamber’in (s.a.v.) evrensel davetini doğru kavramak için, o ifadelerdeki dil ve üslup özelliklerini bilmek gerekir. Bu duyarlılıkla hadislere yaklaşılırsa Hz. Peygamber'in (s.a.v.) üslubu daha net ve doğru kavranmış olur. Hz. Peygamber, İslam’ın cihanşümul mesajını iletirken açık ve yalın cümlelerle dolaysız anlatım biçimine müracaat ettiği gibi; teşbih, mecaz, istiare, kinaye gibi birçok edebî anlatım tarzını da kullanmıştır. Bu çalışmada Hz. Peygamber’in (s.a.v.) üslubu ve anlatım tarzı incelenecektir.Bu çerçevede bu makalede, Hz. Peygamber’in (s.a.v.) anlatım üslubunun kısa bir betimlemesi yapıldıktan sonra din dilinden kısaca söz edilip, rivayetlerde geçen dolaylı anlatım örneklerinden seçkilerle değerlendirme yapılacaktır.
COMPARATIVE ASSESSMENT OF SURGICAL TREATMENT ACUTE INTRACRANIAL HEMATOMAS ACCORDING TO THE HOSPITAL
Authors: Дюсембеков Е.К. , Халимов А.Р. , Курмаев И.Т. , Тян В.К. , Мирзабеков А.Ш. , Николаева А.В. , Жайлаубаева А.С. , Романчик А.А. , Тубелбаев Е.К. , Досым Н. , Балгабек А.
Published: December 2021

Представлены результаты хирургического лечения пациентов с острыми внутричерепными гематомами в различные периоды времени: 522 пострадавших были оперированы в период с 2011 по 2015 гг.; 498 пациентов были оперированы с 2016 по 2020 гг. В последний период экстренных нейрохирургических больных стали принимать дополнительно в трех стационарах, согласно районированию. Отмечено снижение числа пациентов, поступивших в фазе клинической декомпенсации, что можно объяснить сроками доставки в стационар с ближайших районов. Уменьшилась послеоперационная летальность до 17,3% (22,4% в первой группе). Среди умерших пациентов преобладают лица пенсионного возраста (46,5%). 59,3% погибших пациентов прожили менее трех суток.

There is outcome surgical treatment of patients with acute intracranial hematomas at different times: 522 surgeries performed from 2011 to 2015; 498 ones underwent operation during 2016-2020. Recently, emergency neurosurgical procedures have been taking additionally in three hospitals in accordance with neighborhood. We can see decrease of patients with acute management of decompensation traumatic brain injury. This can be explained by their delivery to the nearest hospital. Postoperative mortality reduced to 17.3% (22.4% in the first group). Retirement patients predominate among the dead (46,5%). 59.3% of the mortality defined as less than three days.
MODERN CONCEPT OF CONSERVATIVE TREATMENT OF PREMATURE EJACULATION
Authors: Нисанбаев А.Д. , Нисанбаева А.А. , Сенгирбаев Д.И. , Суранчиев А.Ж. , Ипосунова Г.А.
Published: December 2021

В данной статье представлен обзор методов консервативного лечения преждевременная эякуляция. Отмечено низкая обращаемость пациентов с данной интимной проблемой, и малая информированность об успешном лечении вышеуказанной нозологии. Эффективным методом выбора является применение селективных ингибиторов захвата серотонина, а именно дапоксетина, который обладает высоким уровнем доказательности и удобен как препарат по требованию. Учеными выявлено эффективное применение дапоксетина и ингибиторов 5 альфа-редуктазы в лечении преждевременной эякуляции.

This article provides an overview of the methods of conservative treatment of premature ejaculation. Patients with this intimate problem were noted to have low circulation and low awareness of the successful treatment of the above nosology. An effective method of choice is the use of selective serotonin uptake inhibitors, namely dapoxetine, which has a high level of evidence and is convenient as a drug on demand. Scientists have identified the effective use of dapoxetine and 5 alpha-reductase inhibitors in the treatment of premature ejaculation
ENDOVASCULAR AND OPEN SURGICAL OPERATIONS OF CRITICAL ISCHEMIA OF THE LOWER EXTREMITIES
Authors: Поцелуев Д.Д. , Турсынбаев С.Е. , Сапарбаев Р.А. , Асылбеков Е.А. , Илиев С.А. , Серикбаева М.Е. , Мемишев Т.З.
Published: December 2021

В отделении сосудистой хирургии на протяжении 40 лет (с 1972 по 2012 гг.) было выполнено 9800 открытых операций у больных с КИНК II-IIIст, клинические результаты которых представлены в соответствующем разделе статьи для сравнительного анализа. В основном разделе работы рассматриваются результаты эндоваскулярных хирургических и открытых операций, выполненных у 1088 больных с критической ишемией нижних конечностей II-IIIст (КИНК) и сахарным диабетом (СД). Проведен сравнительный анализ показателей частоты ампутаций при открытых и эндоваскулярных хирургических вмешательствах (ЭХВ). Установлено преимущество ЭХВ в сравнении с открытыми операциями на основании снижения числа ампутаций после выполненных ЭХВ соотвественно с 52,3% до 3,5%.

In the department of vascular surgery, for 40 years (from 1972 to 2012), 9800 open operations were performed in patients with CLI II-IIIst, the clinical results of which are presented in the corresponding section of the article for comparative analysis. The main section of the work examines the results of endovascular surgical and open operations performed in 1088 patients with critical ischemia of the lower extremities II-IIIst (CLI) and diabetes mellitus (DM). A comparative analysis of indicators of the frequency of amputations during open and endovascular surgical interventions (ECS) was carried out. The advantage of ECV in comparison with open operations was established on the basis of a decrease in the number of amputations after ECV performed, from 52.3% to 3.5%, respectively.
CLINICAL ASPECTS OF RENAL TRANSPLANTATION
Authors: Султанова Б.Г. , Мансурова И.Б. , Бодесова С.Б. , Джуманов Н.С. , Сарсенова Ш.А. , Жумагулова Н.А. , Муканова М.К. , Гаражаева Л.Ш.
Published: December 2021

В статье приведен литературный обзор, посвященный современным проблемам в трансплантологии почек. Нерешенными проблемами остаются оценка донора, низкая приверженность пациентов иммуносупрессивной терапии и развитие дисфункции трансплантата. Развивающиеся осложнения после трансплантации и иммуносупрессивной терапии требуют междисциплинарного подхода в лечении и наблюдении реципиентов донорской почки. Также необходимо широкое развитие трупного донорства для снижения числа потенциальных пациентов с хронической болезнью почек.

The article presents a literature review of contemporary problems in kidney transplantation. Donor evaluation, low adherence of patients to immunosuppressive therapy and the development of graft dysfunction remain as unresolved problems. Developing complications after transplantation and immunosuppressive therapy require an interdisciplinary approach in the treatment and monitoring of recipients of donor kidney. It is also indispensable to the development of cadaveric donation to reduce the number of potential patients with chronic kidney disease.
PULMONARY EMBOLISM AFTER SURGICAL RESECTION OF A MENINGIOMA
Authors: Дюсембеков Е.К. , Алгазиев Е.Б. , Жанисбаев А.К. , Анартаев С.М. , Канлов И.А. , Аргумбаев М.Б.
Published: December 2021

В статье представлен клинический случай успешного лечения острой массивной тромбоэмболии лёгочной артерии у пациента после удаления менингиомы. Известно, что частота тромбозов глубоких вен нижних конечностей (ТГВ) в нейрохирургической практике достаточно высока, и может достигать 25-34%. ТГВ является основной причиной более грозной тромбоэмболии легочной артерии (ТЭЛА), частота которой составляет от 1,5% до 3%. На сегодняшний день медицина располагает несколькими эффективными инструментами лечения пациентов с ТЭЛА: от антикоагулянтной терапии до хирургических методов реперфузии. Благодаря слаженной работе в современных многопрофильных клиниках интервенционных кардиохирургов, реаниматологов и нейрохирургов, обеспечивающих своевременную и высокоспециализированную помощь, становится возможным спасение жизней пациентов даже с такой тяжелой и жизнеугрожающей патологией как острая массивная тромбоэмболия легочных артерий.

The article presents a clinical case of successful treatment of acute massive pulmonary embolism in a patient after resection of a meningioma. The incidence of Deep vein thrombosis (DVT) in neurosurgical practice is astonishingly high as it might reach 25-34% in some reports, and represents the first cause for pulmonary embolism (PE), which incidence is thought to be between 1,5% and 3%. Nowadays there are several options for treating patients with pulmonary embolism: from anticoagulant therapy to surgical methods of reperfusion. Effective multidisciplinary teams and coordinated team in our clinics can save the lives of people with pulmonary embolism.
THE NEW APPLIANCE IS USED FOR CIRCUMCISION
Authors: Сахипов М.М. , Еликбаев Г.М.
Published: December 2021

Нами получен патент на полезную модель Республики Казахстан №5782 от 22.01.2021, который с большой эффективностью используется для обрезания крайней плоти. Для отсечения листков крайней плоти применяется устройство для пирографии Stayer, снабженный трансформатором, генерирующий напряжение от 0 до 5 В., с частотой тока 50Гц, мощностью 40Вт., с твердым рабочим наконечником, регулируемым температурой от 450ºС до 750ºС. Применение устройства для пирографии Stayer для обрезания крайней плоти позволяет сократить время оперативного вмешательства, уменьшить травматичность воздействия и улучшить косметический эффект. За 2018-2020 годы было выполнено 500 операций с применением устройства для пирографии Stayer. При этом, среднее время операции составляло 10 минут. У всех детей достигнут хороший непосредственный и отдаленный клинический результат.

We have obtained a patent for a utility model of the Republic of Kazakhstan №5782, 22.01.2021., which is used with great efficiency in circumcision of the foreskin. To cut off the foreskin sheets, a Stayer pyrography device is used, equipped with a transformer that generates a voltage from 0 to 5 V., with a current frequency of 50 Hz, a power of 40 W., with a solid working tip, adjustable temperature from 450 ° C to 750 ° C. The use of the Stayer pyrography device for circumcision of the foreskin allows you to reduce the time of surgical intervention, reduce the traumatic impact and improve the cosmetic effect. In 2018-2020, 500 operations were performed using the Stayer pyrography device. The average operation time was 10 minutes. All children achieved a good immediate and long-term clinical outcome.
Bartonellosi e D-dimero
Authors: Licitra Michela , Acucella Gabriela , Barbaglia Michelangelo , Mazzocchi Paolo , Bottari Gaetano , Guala Andrea
Published: December 2021

The paper reports the case of a 17-year-old immunocompetent boy with persistent fever and elevated D-dimer. The family referred contact with kitten and ingestion of homemade deer salami. Abdominal ultrasound scan and CT showed multiple hepatic and splenic abscesses. High levels of antibody title for Bartonella henselae confirmed the diagnosis of hepatosplenic bartonellosis.
“Klingon baby”: quando il sole fa male alla testa
Authors: Imperatore Agostino , Brienza Carmine , Porto Annamaria , Nunziata Felice
Published: December 2021

The paper describes the case of a 4-year-old boy who presented with sudden head swelling. Clinical findings sustained the diagnosis of “sunburn of the scalp with subsequent oedema of the cutis adjoining the galeal aponeurosis”. Pathogenesis, differential diagnosis and disease management are also discussed.
Myelopathy in sickle cell disease: a case-oriented review
Authors: Brum Igor Vilela , Silva Guilherme Diogo , Sodre Diego Sant'Ana , Nogueira Felipe Melo , Pereira Samira Luisa dos Apostolos , Castro Luiz Henrique Martins
Published: December 2021

Background: Although neurological complications are well recognized in sickle cell disease (SCD), myelopathy has been rarely described. We present the first case report of longitudinally extensive myelitis (LETM) in SCD and review the differential diagnosis of myelopathy in these patients. Design and setting: case-oriented review. Methods: We report the case of a 29-year-old African-Brazilian man with SCD, who experienced a subacute flaccid paraparesis, with T2 sensory level and urinary retention. CSF analysis showed a lymphocytic pleocytosis and increased protein levels. MRI disclosed a longitudinally extensive spinal cord lesion, with a high T2/STIR signal extending from C2 to T12. Serum anti-aquaporin-4 antibody was negative. We searched Medline/ PubMed, Embase, Scopus, and Google Scholar databases for myelopathy in SCD patients. Results: Spinal cord compression by vertebral fractures, extramedullary hematopoietic tissue, and Salmonella epidural abscess have been reported in SCD. We found only three case reports of spinal cord infarction, which is unexpectedly infrequent compared to the prevalence of cerebral infarction in SCD. We found only one case report of varicella-zoster myelitis and no previous report of LETM in SCD patients. Conclusion: Specific and time-sensitive causes of myelopathy should be considered in SCD patients. In addition to compression and ischemia, LETM should be considered as a possible mechanism of spinal cord involvement in SCD.
Impact of meningitis vaccination on mortality and notified cases of the disease in Brazil by region between 2009 and 2019
Authors: Alves Lucca Ribeiro , Neves Rodrigo Bartolomeu Sobral , Oliveira Leonardo Santana Ramos
Published: December 2021

Introduction: Meningitis is a disease with an important history of epidemics during the 20th century. In Brazil, the National Immunization Program (PNI) reduced the general incidence rate of meningitis. However, meningococcal, bacterial,viral and unspecified meningitis are still a challenge in controlling the disease. Objective: Describe data related to vaccination coverage of meningitis, number of deaths and reported cases, between 2009 and 2019, by brazilian region. Design and Setting: Observational study of time series. Methodology: Used secondary data published in DATASUS for the period 2009-2019.The following data were used:Mortality considers deaths from meningitis and meningococcal infection, according to CID- BR-10. Cases were considered by the year of the first symptom and vaccines were evaluated:Meningococcus A/C(MnAC),Meningococcus B/C(MnBC), Meningococcal Conjugate-C (MncC),Meningococcal ACYW1325, Meningococcal B.Proportions were calculated to analyze the trend. Results: 204,211 notifications and 14,562 deaths between 2009 and 2019 were analyzed.The reported cases and deaths from meningitis were decreased by 29% and 34%,respectively.Northeast and Southeast regions stood out with the largest proportional reductions in deaths, with 45% and 37% respectively.For notifications,the Northeast had 54% and the Midwest had a 41% reduction. For Vaccination, all regions had an increase in the period described, with emphasis on the North with an increase of 18,006%,and the Northeast with 30,839%.In addition,the South region increased its applied doses by 499%,with a 4% reduction in deaths,and 10% in notifications. Conclusion:Despite it’s limitations, the analysis suggests the expansion of vaccine coverage contributes positively to the incidence and deaths from meningitis in the Brazilian population.
Prevalence of methylphenidate use without medical prescription among university students: a review of the current reality
Authors: Calixto Nicole Melo , Leal Juliana Ferreira , Nascimento Julyanna Lucas , Colacite Jean
Published: December 2021

Introduction: Methylphenidate is a neuropsychotropic agent, indicated for the treatment of Attention Deficit / Hyperactivity Disorder (ADHD) and narcolepsy, and is commonly prescribed for school and university age patients. The growing prescription of the drug and the misuse of methylphenidate by academics without a diagnosis of ADHD and / or narcolepsy have raised concerns on the part of medical societies of psychiatry. The over-the-counter use of this substance causes potential dependence and adverse effects such as hallucinations, anxiety, dry mouth and visual disturbances. Unfortunately, there is a precarious amount of epidemiological data on the use of methylphenidate without prescription by university students. In view of this reality. Objectives: The present study proposed to review the assessment of the prevalence of methylphenidate consumption without medical prescription in university environments worldwide, with sources published between 2016-2021. Methods: To perform this research, the PubMed (https://pubmed.ncbi. nlm.nih.gov/) and Scielo (https://www.scielo.org/) databases were used as a search tool, using the Key words “non-medical”, “methylphenidate” and “university students”. Results: So far, 10 articles related to the study (carried out in China, Australia, Brazil, South Africa, Iran, Israel, Pakistan and the United States) have been identified, with 8 articles obtained from PubMed and 2 articles acquired from Scielo. The selected articles show that in 6 of these articles the groups of academics studied were undergraduate and graduate students in general areas, and 4 articles in medical students. The studies present cases of students who confirmed the use of methylphenidate without a prescription, with the justification that it improves academic performance even in healthy students. Conclusion: Therefore, further studies on epidemiology and effects on academic performance with the improper consumption of this drug are recommended.
The use of Botulinum toxin type A for the treatment of refractory chronic migraine
Authors: Lemos Gabrielle Torres Oliveira , Benevenuto Gabriel das Chagas , Duarte Gabriela Guy , Pinto Bruno Alves , Viana Ivan Magalhães
Published: December 2021

Background: Chronic migraine is a neurological disorder described as refractory to preventive treatments. Based on the PREEMPT study, the National Institute for Health and Clinical Excellence (NICE) and the FDA approved, in 2010, the use of Botulinum Toxin type A (BoNT/A) to treat refractory chronic migraine. Objectives: To review the effectiveness of the use of BoNT/A in the treatment of refractory migraine. Methods: Bibliographic review based on PubMed database, using the descriptors “migraine” and “botulinum toxin”. Clinical trials, meta-analyzes and randomized controlled tests, from the last five years, were defined as inclusion criteria. Results: Sanz et al., (2016) infiltrated BoNT/A in 69 patients - mean age 43 years old, 88.4% women, mean infiltration rate was 2,0. The reduction of headache days and pain intensity was 48.5% and 20.5%, respectively, both statistically significant (p <0.006). Ion et al., (2018) intervened 61 patients - mean age 50 years old, 87% women, mean infiltration of 3.5. 73% showed a reduction greater than 50% for the frequency of migraine episodes, 48% for headache days and 48% for drug use. Dodick et al., (2019) applied BoNT/A in 688 patients - 696 received placebo. The severity and frequency of pain showed a statistically significant reduction (p < 0.001) after the first week of treatment in relation to the control group. Conclusions: The use of BoNT/A to treat refractory chronic migraine proves to be effective, although there is need for studies with larger samples to ensure its effectiveness.
Regression of Tumor in the Pineal Gland after Exclusive Radiotherapy: Case Report
Authors: Menezes João Lucas Pordeus de , Ramos João Victor Bezerra , Morais Louyse Jerônimo de , Holanda Maurus Marques de Almeida
Published: December 2021

Background: Brain tumors are the most common solid neoplasia and the main cause of death from malignancy in children. Germ cell tumors (GCT) of the central nervous system (CNS) are rare. In pediatrics, the main location is close to the pineal gland and germinomas are the most common intracranial GCTs. Objectives and Methods: To describe the case of a patient with a possible germinoma treated exclusively with radiotherapy. The case was studied and came from a referral hospital – João Pesssoa, PB. Results: Reports “impaired failure”, disorientation and headache. Computed tomography: Hydrocephalus and strong tumor suspicion in the pineal region. Alpha-fetoprotein (AFP) and beta-gonadotropin (betaHCG) measurements: Normal. Treatment can be based on radiotherapy or chemotherapy followed by radiotherapy. In this case, radiotherapy was performed at a dosage of 10 Gy, with control, after one month, by means of magnetic resonance imaging that revealed regression of the lesion. The treatment corroborated the hypothesis of a germinoma, which is extremely radiosensitive. However, the regression made it impossible to perform the anatomopathological exam for diagnostic conclusion. Conclusions: It can be seen, then, that primary CNG GCTs are part of a heterogeneous group of extremely rare lesions, with germinoma therapy still controversial. The case shows regression of a possible germinoma only with the use of radiotherapy.
The use of cannabidiol in the treatment of epilepsy in neuropediatric: a review of the new contributions
Authors: Leal Juliana Ferreira , Calixto Nicole Melo , Girelli Diego Guilherme , Colacite Jean
Published: December 2021

Background: Therapeutic cannabinoids are derived from marijuana, a plant of the cannabis genus. Cannabis sativa and Cannabis indica are the two main species. Cannabis plants contain more than 100 cannabinoids, but the biologically active and therapeutically researched ones are 9 tetrahydrocannabinol (THC) and cannabinol (CBD). Cannabinoids have been advocated for a number of neurological and psychiatric disorders, including multiple sclerosis, mood disorders, schizophrenia, Parkinson’s disease, dystonia, neuropathic pain, nausea, anorexia and epilepsy. Epilepsy is a chronic disease characterized by recurrent unprovoked seizures, affecting more than 50 million people worldwide, in the pediatric age group, with childhood epilepsy being one of the most serious and developing epileptic encephalopathies. Objective: In view of the above, the present study proposed to review the use of cannabidiol in the treatment of epilepsy in neuropediatric, with sources published between 2016-2020. Methods: To perform this research, PubMed (https://pubmeed.ncbi.nlm.nih. gov/) and Scielo (https://www.scielo.org/) databases were used as a search tool, using the Key words “Cannabidiol”, “Epilepsy”, “Cannabis” and “Children”. Results: So far, 11 articles related to the study have been identified, the vast majority being reviewed, with 9 articles obtained from PubMed and 2 acquired from Scielo. Selected articles show that CBD is an effective anticonvulsant in many acute animal models, but its antiepileptic mechanisms are not yet fully recognized. In studies with children in Canada and the United States, they suggest an improvement in the frequency of seizures and an improvement in quality of life, but the numbers are still small. Studies report that CBD is well tolerated, however, it causes sedation, diarrhea and decreased appetite. Conclusions: It is necessary to investigate the safety, pharmacokinetics and interaction between drugs already used by patients and CBD, also conducting more double-blind placebo-controlled trials to obtain conclusive data on their efficacy and safety in the most frequent epilepsies in children.
The use of Amantadine in Cognitive and Behavioral Recovery After Severe Cranioencephalic Trauma: A Systematic Review
Authors: Virgínio Maria Eduarda Cunha , Gonzalez Lara Hessmann , Santos Rafael Rodrigues Pinheiro dos , Rampazzo Ana Carla Mondek , Marin Gabrielli Algazal , Nascimento Mariana Ramos do , Caetano Igor Ruan de Araújo , Nogueira Maria Letícia , Guarnieri José Ângelo Favoreto , Zicarelli Carlos Alexandre Martins
Published: December 2021

Background: Traumatic brain injury (TBI) is the main cause of death among individuals between 1 and 44 years of age, and severe TBI is associated with a mortality rate between 30% and 70%. In this context, randomized clinical trials have studied medications to reduce morbidity in severe TBI, one of which is Amantadine. This drug acts on the increase of extracellular dopamine and as an NMDA antagonist. Objectives: Developing a systematic review of systematic reviews to evaluate the efficacy of Amantadine in reducing morbidity in patients with severe TBI. Methodology: The search was conducted in the PubMed, Embase, Cochrane Library, and Portal Regional BVS databases. Results: Eleven systematic reviews were included. The literature review of 7 articles demonstrated the efficacy of treatment with Amantadine in the following clinical aspects after TBI: aggression, irritability, agitation, mood, and attention deficit. On the other hand, one article did not consider the use of Amantadine significantly beneficial, due to increased agitation in critically ill patients, suggesting that there is worsening of the condition in individuals with cognitive, executive, memory, and attention symptoms. Therefore, three studies reported that there was not enough evidence for the use of this drug in patients with severe TBI. Conclusions: The results are heterogeneous. However, this study found good efficacy of Amantadine for cases of agitation/aggression in severe TBI and in cases of diffuse axonal lesion that compromises the glutamate pathways.