bluuebunny/crossref_metadata_2025 huggingface dataset:
Potential barriers towards optimal medication adherence in out-patients with stable coronary artery disease
Authors: Fitilev S. B. , Vozzhaev A. V. , Shkrebniova I. I. , Kliuev D. A. , Ovaeva A. O.
Published: July 2023

Introduction. The results from foreign and local studies demonstrate that more than a half of patients with cardiovascular diseases do not take medication in compliance with doctors’ recommendations. The search for signiﬁcant barriers to optimal medication adherence might improve the development of adherence control measures in patients with stable coronary artery disease (SCAD) in routine clinical practice of primary care.

Aim. To study the nature and incidence of potential barriers to optimal medication adherence and their association with social and demographic parameters in patients with SCAD.

Methods. This publication describes the fragment of the study “PHARMCARE” in which 123 coronary patients were included. Data on demography, social status, medical history and pharmacotherapy were registered. The barriers to medication adherence were identiﬁed by means of validated scale (questionnaire) SEAMS (Self-Eﬃcacy for Appropriate Medication Use Scale). Data analysis was conducted by descriptive statistics and regression modeling.

Results. The analysis of incidence of barriers to medication adherence allowed to identify the list of most signiﬁcant ones: “fear of side eﬀects”, “intake of several diﬀerent medicines each day”, “intake of medicines more than once a day”, “medicines look diﬀerent than usual”, “normal routine gets messed up”, “busy day planned”, “no one reminds to take medicines” and “staying away from home”. More than a third of all the respondents reported at least one of barriers (37%), that was in major cases “fear of side eﬀects” (22%). Linear one-factor modeling revealed association of number of signiﬁcant barriers in patients with level of their education (р=0,009) and presence of partner or caregiver (р=0,001), that was also conﬁrmed by the multivariate model. Less barriers were identiﬁed in coronary patients that had partner or caregiver (р=0,009) and higher education (р=0,045).

Conclusion. The study results revealed that the signiﬁcant barriers to optimal medication adherence in out-patients with SCAD were related either to patients’ behavior or to pharmacotherapy proﬁle. Uncertainty in overcoming barriers was most typical for single patients without higher education. The obtained results should be taken into consideration when develop strategies for improvement of medication adherence in patients with SCAD in primary care practice.
Risks of clinical trial protocol amendments according to duration of the trial
Authors: Eleskina A. A. , Pyatigorskaya N. V. , Filippova O. V.
Published: July 2023

Background. No clinical trial could be initiated and conducted without appropriate clinical trial protocol. Any change in information relating to patients’ safety and health during the trial must be recorded and approved by a form of amendment to the clinical trial protocol, which is a time-consuming and ﬁnancially expensive process for the Sponsors of these studies.

Goal. To analyze the probability of releasing of clinical trials protocols amendments and to determine the most "pregnable" period for their occurrence in the course of the trials.

Materials and Methods. The results of clinical trial protocols analysis are presented, which were approved by Russian Health Authorities between three years from 2017 to 2019 inclusive. In total, 20 protocols and 39 amendments were analyzed. Results. In the ﬁrst year of the study, 21 amendments were issued, representing slightly more than half (54%) of the total number of amendments. During the second year, 12 amendments were issued, (31%). For the third year of the trial, only 3 amendments (7%) were made and for the fourth — 4, which is 8% of the total.

Conclusion. The largest number of protocol amendments came out at ﬁrst two years of clinical trial. Thus, they are the most "dangerous" years in the life of a clinical study in connection with the examination of developed protocol in real life. These ﬁrst two years show how carefully the protocol was designed, how it meets the requirements of regulatory authorities, criteria and recommendations of professional associations, how feasible and eﬀective the various criteria and procedures are.
Quality assessment of pharmaceutical care to patients with headaches using the simulated patient method: interaction practice
Authors: Reshetko O. V. , Grishin A. I.
Published: July 2023

Relevance. WHO assesses headaches as a global world problem. Russia occupies a leading position in the prevalence of primary headaches. Headaches are one of the most common reasons for visiting a pharmacy for self-medication. The interaction of the pharmacist and the visitor with the headache problem in general determines the quality of pharmaceutical care.

Aim. To assess the practice of the interaction between a patient with a headache and a pharmacist using the simulated patient method.

Materials and methods. Trained simulated patients (women aged 20, 40 and 58 years) visited a total of 101 pharmacies. The dialogue was recorded on a voice recorder, all the features of the interaction were additionally recorded aﬅer the visit. Special forms were ﬁlled out based on the information received. The data was processed using Microsoﬅ Excel 2010 and STATISTIKA 10.0.

Results. The average interaction time was 98.2±3.8 seconds. There was a high frequency of spontaneous recommendations without preliminary questions (66.3%), a small number of questions asked (0.84±0.1). These indicators practically did not depend on various factors (type of pharmacy organization, age of the pharmacist, age of the simulated patient, the presence of a queue, and others).

Conclusion. The results of the study demonstrate a low level of interaction between pharmacists and visitors with a headache, as well as a practical absence of involvement in the process of providing pharmaceutical care, which negatively aﬀects its quality: frequent spontaneous recommendations, short consultations and rare questions. The approach to the interaction of pharmacists with visitors with headaches is formal and requires standardization.
Pharmacoeconomical analysis of the use of upadacitinib, baricitinib and dupilumab for systemic therapy of patients with moderate and severe atopic dermatitis
Authors: Zyryanov S. K. , Dyakov I. N. , Ilina N. I.
Published: July 2023

Objective. Comparative pharmacoeconomic evaluation of upadacitinib, baricitinib and dupilumab for the treatment of moderate to severe atopic dermatitis.

Materials and methods. Study design — retrospective. Pharmacoeconomic analysis method — cost-eﬀectiveness analysis, budget impact analysis. Data sources. On the eﬀectiveness of compared alternatives — meta-analysis of randomized clinical trials for the compared drugs, clinical recommendations; on the cost of drugs — the state register of maximum selling prices.

Results. Lowest cost-eﬀectiveness (CER) values for both EASI-75 and EASI-90 responses were for upadacitinib. For upadacitinib 15 mg/day, the cost of achieving EASI-75 and EASI-90 responses was reduced by 63.9 and 70.3%, respectively compared to dupilumab and by 44.2 and 46.8% compared to baricitinib. For upadacitinib 30 mg/day, the reduction in the cost of achieving the eﬀect compared to dupilumab will be, respectively, 40.8 and 56.2%, and compared with baricitinib — 8,5 and 21.4%. The budget impact analysis (BIA) showed that the increase in the share of upadacitinib from 15 to 35%, and the proportion of baricitinib — from 5 to 10% due to a decrease in the proportion of patients, receiving dupilumab will reduce the budget impact in the treatment of patients with severe atopic dermatitis on the scale of the Russian Federation by a total of 11.6% (RUB 1.25 billion) with a single-step change from the ﬁrst year and by 7.9% (RUB 0.86 billion) with a gradual change over 3 years. An analysis of missed opportunities showed that if the share of upadacitinib changes to 35% 741 patients can be additionally provided with therapy in the ﬁrst year, 629 patients in the second year and 567 patients in the third (with a target population size of 4929 patients).

Conclusion. Increasing the share of upadacitinib will not only signiﬁcantly reduce the burden on the budget of the healthcare system by refusing to use more expensive dupilumab in some patients, but also increase the proportion of patients achieving the goals of therapy in terms of EASI-75 and EASI-90.
Interdepartmental Collaborative Lesson Research (CLR) in a Japanese University
Authors: Black Miriam , Underwood Paul , Kolodziej Magdalena , Kohno Takeshi
Published: July 2023

Lesson study (jugyō kenkyū) has unique benefits for both students and teachers, and it is one means of addressing what McKinley (2022) described as the teaching-research nexus. In this article, we provide details of our ongoing lesson study project in a Japanese university to demonstrate this. First, we review the theoretical background of lesson study and explain Collaborative Lesson Research (CLR), a particular form of lesson study which guided our project. Then, we explain how and why our group was formed. For our project, the research theme has been the implementation of active learning approaches to lead EFL students to develop a clearer and more critical understanding of course material in English. Then, we explain the process of our project, discuss key teacher learning, and present preliminary evidence of student learning. In doing so, we highlight the strengths and benefits of CLR and suggest additional key elements of effective projects.

授業研究は、学生のみならず教員にとっても有意義な経験をもたらし、それはMcKinley (2022)が提唱する教育と研究の関連性を扱うひとつの方法でもある。本論では、本学で現在進行中の授業研究プロジェクトを紹介することを通じこの関連性を提示する。まず、授業研究の理論的背景を概観し、授業研究における特定の形態である共同的授業研究（CLR）を説明する。さらにこのプロジェクトを実施することになったグループ形成に至る経緯を説明する。我々のCLRプロジェクトのテーマは、アクティブ・ラーニングのアプローチを通じ、英語の課題を明確かつ批判的にEFLの学生が理解できるように促すことである。次に、我々のCLRプロジェクトの過程、それに参加した教員の学び、そして学生の学びの初期段階の証拠を提示する。この試みを通じ、CLRアプローチの強みと有益性を強調しつつ、効果あるプロジェクトの鍵となる追加的要素を提案する。
Philosophy Study in the Development of Reading Teaching Materials Based on Cultural Wisdom of Betawi Fairy Tales
Authors: Pudjiati Danti , Mawarni Venti
Published: July 2023

The purpose of this study was to examine the philosophical study contained in the development of reading teaching materials based on cultural wisdom of Betawi fairy tales for grade X science students at SMAN 107 Jakarta. This research was  qualitative research with a descriptive method. Data collection techniques were carried out through library research on references related to the topics discussed namely teaching materials, readings, and Betawi fairy tales. The results of this research regarding the development of reading teaching materials based on cultural wisdom of Betawi fairy tales then were analyzed using three philosophical studies namely Ontology, Epistemology and Axiology. The Ontology study was employed to examine the development of reading teaching materials with cultural wisdom of Betawi tales. Next, Epistemology was formulated to design and make prototypes of the development of teaching materials so that they can be evaluated and get feedback from the parties involved. Subsequently, the axiology which focused on value of educational technology was intended to intrigue and promote a sense of humanity among students through the depiction of the characters told in the fairy tale.
Impact of Flipped Classroom on Elementary Students' Creative Thinking in the Merdeka Curriculum
Authors: Kartika Regita Pramesty , Wahyuni Akhtim
Published: July 2023

Creative thinking ability is the ability to create an idea to solve a problem. SDN Glagaharum is one of the elementary schools that has a relatively low creative thinking ability, this can be seen from the ability of students to understand the material in the Merdeka curriculum. To address this, researchers explored the use of the flipped classroom learning model. This study was conducted with the aim of knowing how the flipped classroom model affects the basic creative thinking skills of school students in implementing the Merdeka curriculum. Employing a quantitative experiment, the Posttest Only Control Group Design was employed with a population of 40 fourth-grade students from SDN Glagaharum. Two samples, IV-A (experiment class with 20 students) and IV-B (control class with 20 students), were utilized. Data analysis included normality and homogeneity tests, along with paired sample t-test conducted in SPSS 26. The findings revealed that the flipped classroom learning model had a significant effect on the creative thinking ability of fourth-grade students at SDN Glagaharum within the context of the Merdeka curriculum.
Kimya Eğitiminde Sorgulamaya Dayalı Öğrenmenin Bibliyometrik Analizi
Authors: Ayna Sezgi , Şen Şenol
Published: July 2023

Bu çalışmada kimya eğitiminde sorgulamaya dayalı öğrenme yönteminin kullanımına ilişkin bibliyometrik analiz yöntemi kullanılarak araştırma alanının yapısını ve gelişimini ortaya çıkarmak amaçlanmıştır. Bu amaç kapsamında Web of Science (WoS) veri tabanında 15 Kasım 2022 tarihine kadar kimya eğitiminde sorgulamaya dayalı öğrenme yönteminin kullanımı ile ilgili yayınlanmış 875 makale, performans analizi ve bilim haritalama kullanılarak analiz edilmiştir. Betimsel analiz sonucunda; en çok çalışma yapan yazarın Ellen J Yezierski olduğu ortaya çıkarılmıştır. Bilim haritalama bulgularına göre; en etkili dokümanın Abd-El-Khalick vd. (2004), en etkili kaynağın ‘Journal of Chemical Education’ ve en etkili ülkenin ABD olduğu belirlenmiştir. En etkili ilk üç yazarın Joseph S. Krajcik, Ronald W. Marx ve Fouad Abd-El-Khalick olduğu tespit edilmiştir. Birlikte en fazla atıf alan yazarlar; National Research Council (NRC), Avi Hofstein ve Barbara A. Crawford iken; birlikte en fazla atıf alan referanslar ise NRC (1996), Hofstein ve Lunetta (2004) ve NRC (2000) şeklindedir. Ayrıca en fazla kullanılan anahtar kelimenin; ‘inquiry based/discovery learning’ olduğu belirlenmiştir. Bu çalışmanın hem literatüre katkı sağlanması hem de bu alanda yeni olan araştırmacılara yol gösterici olması beklenmektedir.
El desarrollo socio afectivo y su relación con el aprendizaje cooperativo de los niños
Authors: Urbina Aguirre María Belén , Guayta Sailema María Cecilia , Toasa Yugcha Rosa Jeanette , Jara Silva Mery Verónica , Solís Chinche Rubén Rodrigo
Published: July 2023

El presente trabajo se refiere al desarrollo del nivel socio – afectivo del niño; el objetivo general es la determinación del grado de relación del desarrollo socio afectivo en el Aprendizaje Cooperativo en los niños, la metodología se basa en un enfoque cuantitativo porque analiza y busca comprender el desarrollo afectivo y el aprendizaje cooperativo; también es cuantitativo por los datos numéricos que fueron tabulados. De los resultados hay conclusiones que beneficia a los niños apoyándose en recomendaciones. Finalmente, en este trabajo se propone la creación de un Club de Role – Playing con el uso de una guía didáctica para su aplicación en los niños que son la parte esencial de toda esta investigación.
NIC 41, tratamiento financiero del proyecto acuícola de la prefectura de Santa Elena, 2022
Authors: Pita González Carlos Danilo , Suárez Mena Karla Estefanía
Published: July 2023

Este artículo científico tiene como propósito analizar el tratamiento financiero y contable del proyecto acuícola de la prefectura de Santa Elena, en particular el registro contable de las ostras según la NIC 41. El objetivo es mejorar la precisión y eficacia de los estados financieros al comprender y aplicar adecuadamente los principios contables relacionados con los activos biológicos y productos agrícolas. Se busca identificar áreas de mejora en la contabilidad, analizar el proceso de registro y valoración de las ostras, diseñar un tratamiento contable adecuado para los productos agrícolas derivados y evaluar la implementación de la NIC 41. La metodología utilizada es cuanti-cualitativa descriptiva, empleando investigación documental, entrevistas y observación. Los resultados y discusiones se centran en destacar deficiencias contables que necesitan mejoras. En resumen, este artículo busca mejorar el registro contable de los activos biológicos y productos agrícolas en el proyecto acuícola de la prefectura de Santa Elena, siguiendo la norma NIC 41, con el propósito de proporcionar información relevante para la toma de decisiones y políticas internacionales.
Fenotipificación de dos sistemas de producción de ovinos pelibuey (ovis aries) en la Amazonia ecuatoriana
Authors: Guerra Campaña Ricardo Sebastián , Quinteros Pozo Orlando Roberto , Masaquiza Aragón Joffre Javier , Moyano Tapia Juan Carlos
Published: July 2023

La raza de ovinos Pelibuey es de suma importancia en la obtención de carne en Ecuador, específicamente en la Amazonía. Se ha convertido en una de las alternativas del productor de la zona para convivir sin afectar el bosque nativo realizando un pastoreo inteligente. El Módulo Ovino Amazónico Sustentable, MOAS, se idea en el año 2016, y se implementa en el año 2018, este modelo nace de una necesidad de complementar los sistemas de producción tradicional en la Amazonía Ecuatoriana, convirtiéndose en un sistema de producción alternativo de baja inversión y alta rentabilidad. El objetivo del presente estudio fue el de caracterizar mediante la fenotipificación dos sistemas de producción en ovinos Pelibuey en la Amazonia ecuatoriana. Se manejaron 20 ovejas de pelo, de raza Pelibuey, 10 ovejas de cada sistema de producción en estudio (G1, Vencedores, Puyo, Pastaza, G2, Talag, Tena, Napo), de 24 a 32 meses de edad. Al inicio del ensayo todas las hembras presentarán estado clínico normal en lo que respecta a funcionalidad del aparato digestivo, respiratorio y circulatorio, temperatura corporal, comportamiento alimentario y social. Los dos sistemas de producción evaluados difieren estadísticamente en las variables, peso vivo (PV), altura a la cruz (ALC), ancho anterior de la grupa (AAG), diámetro de caña (DC), diámetro torácico (DT) y largo de la canal (LC).  Mostrándose por encima de los valores reportados para esta raza. Los resultados del perfil metabólico, obtenidos en suero sanguíneo de ovejas Pelibuey, de los G1 y G2, los mismos que mostraron diferencia significativa (p˂0,05), entre si en las variables Mg, Urea y Creatinina y no mostraron diferencias significativas entre si (p˂0,05), en las variables proteínas totales, Ca y P, esto estaría indicando que con estas variables no podríamos diferenciar ambos sistemas de producción fenotípicamente. Se logró caracterizar a través de su fenotipo y análisis sanguíneo a los dos sistemas de producción utilizados para el ensayo. Existe una marcada diferencia entre el sistema de producción VENCEDORES y el sistema de producción MOAS, en cuanto a la mayoría de las variables analizadas.
Diseño de escenarios clínicos complejos mediante simulación clínica para estudiantes de posgrado de la especialidad de Pediatría del Hospital Universitario de Puebla, México.
Authors: Silva Campos Irlanda Mariel , Yaneth Martínez Tovilla  , Guevara Navarrete César Martín , López Santos Héctor Alfonso , Márquez Toledo Aquilino , Morales Morales Flor Lucía , Navarro Tovar Fernando
Published: July 2023

La simulación clínica como estrategia docente promueve la integración de conocimientos , habilidades clínicas complejas así como actitudinales, aumentado el grado de retención de lo aprendido cuando se compara con los métodos docentes tradicionales. Los escenarios de simulación clínica deben ser relevantes para el grado académico en que se encuentra el participante.  Para construir un escenario de simulación clínica debe tomarse en cuenta: 1- La población a la que va dirigida. 2-Definir la complejidad del caso 3-Establecer los objetivos de aprendizaje. 4-Revisión de la bibliografía. Se debe realizar una revisión bibliográfica que documente las bases sobre las cuales se desarrollará el escenario, en conjución con guías de práctica clínica y normas oficiales mexicanas, así como revisiones de casos publicados o  de casos clínicos reales. En Pediatría se crean escenarios clínicos muy parecidos a la realidad en centros u hospitales que cuentan con áreas de simulación en diversas situaciones clínicas según las diferentes etapas fisiológicas del desarrollo del niño, lo cual permite al estudiante de posgrado abordar las intervenciones específicas, desarrollar habilidades procedimentales con un mínimo de estrés, integrarse en el trabajo en equipo para el  desarrollo de competencias actitudinales con la finalidad de mejorar un futuro desempeño durante la práctica clínica real.
Weighted discrete Hardy's inequalities
Authors: Lefèvre Pascal
Published: July 2023

UDC 517.5
We give a short proof of a weighted version of the discrete Hardy inequality. This includes the known case of classical monomial weights with optimal constant. The proof is based on the ideas of the short direct proof given recently in [P. Lefèvre, Arch. Math. (Basel), 114, № 2, 195–198 (2020)].
Comportamento da temperatura do fluido injetado no reservatório em operações de acidificação de matriz
Authors: MEDEIROS JUNIOR F. , Trevisan Osvair Vidal
Published: July 2023

As operações de Acidificação de Matriz são usadas com freqüência para remoção do dano à formação causado por partículas sólidas de minerais que obstruem parcialmente o espaço poroso nas proximidades do poço. A cinética da reação química entre o ácido e os minerais da rocha é bastante sensível à temperatura na qual a reação se desenvolve. A temperatura do ácido na zona injetora depende dos fenômenos de transferência de calor que ocorrem no interior da coluna de injeção e no reservatório submetido à injeção do ácido. Normalmente utiliza-se pequenos volumes de ácidos bombeados com vazões médias e altas tendo como conseqüência pequenos períodos de injeção. O modelo proposto para o cálculo da temperatura na coluna considera os termos de acumulação de calor no interior da coluna e no anular, além da hipótese de poço com raio finito, importantes para soluções de curto tempo. No reservatório são consideradas as perdas para a formação vizinha e analisada a influência do calor gerado pela reação química no comportamento da temperatura do ácido. As hipóteses de condução de calor desprezível na direção do fluxo de fluido, equilíbrio térmico instantâneo, gradiente geotérmico linear e condução de calor unidimensional na formação também são utilizadas. A solução para temperatura do ácido na zona injetora é apresentada no espaço de Laplace considerando o acoplamento da solução para temperatura na coluna à solução para a temperatura no reservatório através do teorema da convolução. A inversão numérica das funções no espaço de Laplace e feita com o algoritmo de Stehfest. Os resultados obtidos indicam que a temperatura do ácido na zona inietora é bastante sensivel à vazão do ácido injetado e aos volumes deslocados a frente do tratamento, podendo atingir valores significativamente inferiores à temperatura do reservatório no decorrer da operação.
Implementasi Web Service Restful Dengan Autentikasi JSon Web Token Berbasis Web dan Android
Authors: Pudoli Ahmad , Yulianawati Yulianawati , Suwandi Iqbal
Published: July 2023

Sistem pembelajaran saat ini mendapatkan pengaruh sangat besar oleh perkembangan teknologi, dalam melakukan pemanfaatan pembelajaran ini memudahkan antara murid dan guru untuk tidak harus bertemu secara langsung. Pada sistem pembelajaran ini adalah untuk memberikan kemudahan kepada pengguna. Pada pembuatan aplikasi sistem pembelajaran ini membutuhkan bagian CMS (Content Management System) yang berguna untuk mengelola dibagian belakang dari user interface agar mudah di kelola dan sangat user friendly. Oleh karena itu perlu dibuat suatu aplikasi sistem pembelajaran untuk meningkatkan proses kinerja pada yang semula manual menjadi terkomputerisasi. Pada pembuatan program aplikasi ini dikembangkan dengan bahasa JavaScript. Sementara untuk integrasi dengan sistem yang sudah ada diperlukan web service sebagai backend system sehingga sistem pembelajaran dapat diakses oleh berbagai platform. Arsitektur yang digunakan pada web service menggunakan REST API, namun masih ada beberapa masalah pada REST API yaitu mengenai keamanan pada proses otentikasi. Pada arsitektur REST API diperlukan metode otentikasi, salah satunya dapat menggunakan JSON Web Token. Hasil penelitian ini menunjukan bahwa penggunaan JSON Web Token Authentication pada web service aplikasi CMS (Content Management System) dapat membentuk sistem yang sangat skalabilitas, mampu berinteraksi multiplatform. Setelah tahap penelitian pengembangan sustem dibuat, dan dilakukan proses pengujian dengan blackbox serta usability semua pengujian yang berhubungan dengan fungsionalitas aplikasi di android dan web dapat diterima serta dapat dijalankan sesuai yang diharapkan. Dari hasil pengujian usability, diperoleh tingkat keberhasilan dalam sistem dalam menyimpan data di flatform android sebesar 97% , keberhasilan dalam menyimpan di website 98%, jika data yang diinput terdapat kesalahan pada jenis tipe data maupun panjang karakternya oleh karena itu aplikasi ini dapat dinyatakan memiliki kualifikasi sangat baik dan berhasil.
Sistem Pelayanan Nasabah Berbasis Web pada Bank Mandiri KCP Tangerang Sepatan
Authors: Iqbal Muchamad , Mariana Arni Retno , Gurning Nurhaida
Published: July 2023

Pelayanan yang terdapat pada Bank mandiri KCP Tangerang Sepatan saat ini masih belum memenuhi kebutuhan nasabah secara fungsionalitas. Penelitian ini bertujuan untuk menghasilkan suatu perancangan sistem informasi pelayanan berbasis web yang dapat digunakan untuk pelayanan nasabah, dan mampu mendukung peningkatan mutu kinerja dan kualitas pelayanan pada Bank mandiri KCP Tangerang Sepatan.Dalam penelitian ini dimulai dari tahap menganalisa sistem yang ada saat ini yang diperoleh dari wawancara langsung dengan pihak terkait dan observasi. Perancangan sistem yang diusulkan ini dibuat dengan menggunakan metode SDLC (System Development Life Cycle) dengan model proses waterfall. Sedangkan untuk pembuatan perangkat lunaknya dibuat dengan menggunakan aplikasi atau tools Adobe Dreamweaver CS6 yang dipadukan dengan bahasa pemrograman PHP, Framework W3 dan basis data MySQL.
The Effect of The Number of Preovulatory Follicles Developed by Ovulation Induction with GND and Clomiphene Citrate for IUI Treatment in Unexplained Infertility on Pregnancy Rates
Authors: HALİLZADE Mohammad İbrahim , KAHYAOĞLU Serkan , HALİLZADE İnci , FİLİZ Ahmet Arif , KURU PEKCAN Meryem , ÖZAKŞİT Gülnur
Published: July 2023

Aim: The aim of this study is to investigate whether the number of dominant follicles formed in IUI with ovarian stimulation (OS) affects pregnancy outcomes in couples with unexplained infertility.

Material and Method: 217 couples aged 24-39 years with unexplained infertility and treated with IUI by way of OS participated in our study. The patients were divided into 2 groups of which the first included the clinically pregnant and the second did not, and were compared in terms of age, monofollicle and bifollicle development, infertility duration, treatment initiation day, hcg day, leading follicle diameter, endometrial thickness, number of dominant follicles and treatment type.

Results: Of the 217 patients who underwent IUI for unexplained infertility, no significant difference was found between the groups with and without clinical pregnancy in terms of the number of dominant follicles (p=0.73). There was a positive but low correlation between endometrial thickness and treatment success (Spearman's correlation coefficient value = 0.14, p=0.03). The receiver operating characteristic curve analysis revealed that the optimal cut-off value for endometrial thickness to predict pregnancy success was 9.5 mm (55.0% sensitivity, 65.0% specificity).

Conclusions: As a result, we suggest that gonadotropins are not superior to oral agents in terms of clinical pregnancy rates in unexplained infertility, therefore treatment should commence with less invasive and less costly oral agents. Furthermore, we think that the number of dominant follicles (monofollicles or bifollicles) created by ovarian stimulation does not affect clinical pregnancy success, but endometrial thickness is closely related to pregnancy rates and deserves attention.
Investigating The Effect Of Marketing Mix Through Motivation On Purchase Intention In Perumnas Griya Jetis Permai Mojokerto
Authors: PUSPITO Atras Radifan , SHIRATINA Aldina
Published: July 2023

This research aims to examine the direct and indirect effects of Product, Price, Promotion, Place, and Motivation on Purchase Intention at Perumahan Griya Jetis Permai Mojokerto. The research sample consists of 255 respondents who are buyers that have gone through the marketing and sales process. Non-Probability Sampling method was used for data collection, employing a Likert scale questionnaire. The data analysis method used in this study is Partial Least Square-Structural Equation Modelling (PLS-SEM) through Outer Model, Inner Model, and Resampling Bootstrap. The results of the study show that Product, Price, Promotion, and Place have a positive and significant influence on Motivation. Motivation also has a positive and significant effect on Purchase Intention. Additionally, Product and Promotion have a positive and significant impact on Purchase Intention. However, Price and Place do not have a positive and significant effect on Purchase Intention. Overall, the research results indicate that Motivation plays a mediating role as an intervening variable between Product, Price, Promotion, and Place on Purchase Intention at Perumahan Griya Jetis Permai Mojokerto. The findings of this study can be used as a guide for Perumahan Griya Jetis Permai Mojokerto in designing effective marketing strategies to enhance Purchase Intention.
Geographic Information Systems Assessment Implementation in the Further Education and Training Phase in Schools
Authors: Mkhize Thulasizwe Fredrick , Zondi Thabile Aretha , Mngomezulu Halalisani
Published: July 2023

National Senior Certificate (NSC) diagnostic reports for matric results indicate that learners perform poorly in Geographic Information Systems (GIS). While GIS education has made significant strides in recent years, there is a need for research that explores Geography teachers’ perceptions of GIS assessment. This paper explored the perceptions of Geography teachers in implementing GIS assessment in the Further Education and Training (FET) phase in South African schools. This research is underpinned by the constructivism theory by Piaget, which argues that learners actively construct knowledge and understanding of the world through their interactions with their environment. This paper focused on the classroom environment because that is where Geography learners are taught GIS. Learners must be exposed to different teaching and learning methods that assist them in utilising their existing knowledge to construct an understanding of the world around them. Particularly, Geography learners must be taught GIS thoroughly to apply the knowledge and skills they have learnt in real situations and be better prepared for assessment. The qualitative research design and a case study methodology were used to frame this research. Six teachers from three schools were chosen to participate in this study. Semi-structured interviews were used to generate data. The findings of this study indicated that Geography teachers teach GIS for assessment. The teachers stated that teaching learners using past year papers is ineffective because the Department of Basic Education (DBE) often changes the GIS content and skills they test. Hence, it is difficult to predict what they will assess; the DBE does not provide proper guidelines on how GIS content and skills would be tested. It is recommended that there must be a collaboration between the DBE and higher education institutions to offer Geography teachers guidance and training on GIS content, skills, and assessment.

Keywords: Geography, Geographic Information Systems (GIS), Assessment, Secondary school education.
The Great Dimming of the Hypergiant Star RW Cephei: CHARA Array Images and Spectral Analysis
Authors: Anugu Narsireddy , Baron Fabien , Gies Douglas R. , Lanthermann Cyprien , Schaefer Gail H. , Shepard Katherine A. , Brummelaar Theo ten , Monnier John D. , Kraus Stefan , Le Bouquin Jean-Baptiste , Davies Claire L. , Ennis Jacob , Gardner Tyler , Labdon Aaron , Roettenbacher Rachael M. , Setterholm Benjamin R. , Vollmann Wolfgang , Sigismondi Costantino
Published: July 2023

The cool hypergiant star RW Cephei is currently in a deep photometric minimum that began several years ago. This event bears a strong similarity to the Great Dimming of the red supergiant Betelgeuse that occurred in 2019–2020. We present the first resolved images of RW Cephei that we obtained with the CHARA Array interferometer. The angular diameter and Gaia distance estimates indicate a stellar radius of 900–1760 R
⊙, which makes RW Cephei one of the largest stars known in the Milky Way. The reconstructed, near-infrared images show a striking asymmetry in the disk illumination with a bright patch offset from the center and a darker zone to the west. The imaging results depend on assumptions made about the extended flux, and we present two cases with and without allowing extended emission. We also present a recent near-infrared spectrum of RW Cep that demonstrates that the fading is much larger at visual wavelengths compared to that at near-infrared wavelengths as expected for extinction by dust. We suggest that the star’s dimming is the result of a recent surface mass ejection event that created a dust cloud that now partially blocks the stellar photosphere.
The Impact of Cosmic Variance on Inferences of Global Neutral Fraction Derived from Lyα Luminosity Functions during Reionization
Authors: Bruton Sean , Scarlata Claudia , Haardt Francesco , Hayes Matthew J. , Mason Charlotte , Morales Alexa M. , Mesinger Andrei
Published: July 2023

We investigate the impact of field-to-field variation, deriving from cosmic variance, in measured Lyα emitter (LAE) luminosity functions (LFs) and this variation’s impact on inferences of the neutral fraction of the intergalactic medium (IGM) during reionization. We post-process a z = 7 IGM simulation to populate the dark matter halos with LAEs. These LAEs have realistic UV magnitudes, Lyα fluxes, and Lyα line profiles. We calculate the attenuation of Lyα emission in universes with varying IGM neutral fraction,

x

¯

H

I

. In a

x

¯

H

I

= 0.3 simulation, we perform 100 realizations of a mock 2 deg2 survey with a redshift window Δz = 0.5 and flux limit f
Lyα
> 1 × 10−17 erg s−1 cm−2; such a survey is typical in depth and volume of the largest LAE surveys conducted today. For each realization, we compute the LAE LF and use it to recover the input

x

¯

H

I

. Comparing the inferred values of

x

¯

H

I

across the ensemble of the surveys, we find that cosmic variance, deriving from large-scale structure and variation in the neutral gas along the sightline, imposes a floor in the uncertainty of

Δ

x

¯

H

I

∼
0.2

when

x

¯

H

I

= 0.3. We explore mitigation strategies to decrease this uncertainty, such as increasing the volume, decreasing the flux limit, or probing the volume with many independent fields. Increasing the area and/or depth of the survey does not mitigate the uncertainty, but composing a survey with many independent fields is effective. This finding highlights the best strategy for LAE surveys aiming at constraining the

x

¯

H

I

of the universe during reionization.
Properties of the Turbulence and Topology in a Turbulent Magnetic Reconnection
Authors: Zhang W. Z. , Fu H. S. , Cao J. B. , Wang Z. , Liu Y. Y.
Published: July 2023

Magnetic reconnection is a crucial process responsible for energy conversion and particle acceleration in space, astrophysical, and laboratory plasmas. Turbulence and magnetic reconnection can be mutually driven, but the underlying nature of energy dissipation, intrinsic turbulence waves, and magnetic field topologies in turbulent magnetic reconnection is still poorly understood. Here, using advanced multi-spacecraft mission and innovative methods, we provide a few new perspectives to investigate the properties of the turbulence and topology in a turbulent magnetic reconnection in the magnetotail. Our results reveal that in turbulent magnetic reconnection: (1) cyclotron resonance, an important mechanism of energy dissipation, is more effective in the core region of the reconnection than in the outflow regions; (2) energy is deposited in the form of kinetic Alfvén waves (KAWs) and fast/slow waves, with KAWs corresponding to low-frequency (ion cyclotron scale) and fast/slow waves corresponding to high-frequency (low-hybrid scale); and (3) the number of spiral nulls (O-lines) were about 3.6 times more than radial ones (X-lines), and three-dimensional structures were about 8 times more prevalent than two-dimensional ones. These findings should help us better unravel the dynamics of turbulent magnetic reconnection.
The Fate of the Interstellar Medium in Early-type Galaxies. II. Observational Evidence for Morphological Quenching*
Authors: Leśniewska Aleksandra , Michałowski M. J. , Gall C. , Hjorth J. , Nadolny J. , Ryzhov O. , Solar M.
Published: July 2023

The mechanism by which galaxies stop forming stars and get rid of their interstellar medium (ISM) remains elusive. Here, we study a sample of more than 2000 elliptical galaxies in which dust emission has been detected. This is the largest sample of such galaxies ever analyzed. We infer the timescale for removal of dust in these galaxies and investigate its dependence on physical and environmental properties. We obtain a dust-removal timescale in elliptical galaxies of τ = 2.26 ± 0.18 Gyr, corresponding to a half-life time of 1.57 ± 0.12 Gyr. This timescale does not depend on environment, stellar mass, or redshift. We observe a departure of dusty elliptical galaxies from the relation between star formation rate and dust mass. This is caused by the star formation rates declining faster than the dust masses and indicates that there exists an internal mechanism that affects star formation but leaves the ISM intact. Morphological quenching together with ionization or outflows caused by older stellar populations (Type Ia supernovae or planetary nebulae) is consistent with these observations.
Real-time Likelihood Methods for Improved γ-Ray Transient Detection and Localization
Authors: Kerr M. , Duvall W. , Johnson W. N. , Woolf R. S. , Grove J. E. , Kim H.
Published: July 2023

We present a maximum-likelihood (ML) algorithm that is fast enough to detect γ-ray transients in real time on low-performance processors often used for space applications. We validate the routine with simulations and find that, relative to algorithms based on excess counts, the ML method is nearly twice as sensitive, allowing detection of 240%–280% more short γ-ray bursts. We characterize a reference implementation of the code, estimating its computational complexity and benchmarking it on a range of processors. We exercise the reference implementation on archival data from the Fermi Gamma-ray Burst Monitor (GBM), verifying the sensitivity improvements. In particular, we show that the ML algorithm would have detected GRB 170817A even if it had been nearly 4 times fainter. We present an ad hoc but effective scheme for discriminating transients associated with background variations. We show that the onboard localizations generated by ML are accurate, but that refined off-line localizations require a detector response matrix with about 10 times finer resolution than is the current practice. Increasing the resolution of the GBM response matrix could substantially reduce the few-degree systematic uncertainty observed in the localizations of bright bursts.
AT 2023clx: The Faintest and Closest Optical Tidal Disruption Event Discovered in Nearby Star-forming Galaxy NGC 3799
Authors: Zhu Jiazheng , Jiang Ning , Wang Tinggui , Huang Shifeng , Lin Zheyu , Wang Yibo , Wang Jian-Guo
Published: July 2023

We report the discovery of a faint optical tidal disruption event (TDE) in the nearby star-forming galaxy NGC 3799. Identification of the TDE is based on its position at the galaxy nucleus, a light curve declining as t
−5/3, a blue continuum with an almost constant blackbody temperature of ∼12,000 K, broad (≈15,000 km s−1) Balmer lines, and characteristic He ii 4686 Å emission. The light curve of AT 2023clx peaked at an absolute magnitude of −17.16 mag in the g band and a maximum blackbody bolometric luminosity of 4.56 × 1042 erg s−1, making it the faintest TDE discovered to date. With a redshift of 0.01107 and a corresponding luminosity distance of 47.8 Mpc, it is also the closest optical TDE ever discovered to the best of our knowledge. Furthermore, our analysis of Swift/XRT observations of AT 2023clx yields a very tight 3σ upper limit of 9.53 × 1039 erg s−1 in the range 0.3–10 keV. AT 2023clx, together with very few other faint TDEs such as AT 2020wey, prove that there are probably a large number of faint TDEs yet to be discovered at higher redshifts, which is consistent with the prediction of luminosity functions (LFs). The upcoming deeper optical time-domain surveys, such as the Legacy Survey of Space and Time and the Wide Field Survey Telescope, will discover more TDEs at even lower luminosities, allowing for a more precise constraint of the low end of the LF.
Collapsar Black Holes Are Likely Born Slowly Spinning
Authors: Gottlieb Ore , Jacquemin-Ide Jonatan , Lowell Beverly , Tchekhovskoy Alexander , Ramirez-Ruiz Enrico
Published: July 2023

Collapsing stars constitute the main black hole (BH) formation channel, and are occasionally associated with the launch of relativistic jets that power γ-ray bursts (GRBs). Thus, collapsars offer an opportunity to infer the natal (before spin-up/down by accretion) BH spin directly from observations. We show that once the BH saturates with a large-scale magnetic flux, the jet power is dictated by the BH spin and mass accretion rate. Core-collapse simulations by Halevi et al. and GRB observations favor stellar density profiles that yield an accretion rate of

m

̇

≈

10

−
2

M

⊙

s

−
1

, weakly dependent on time. This leaves the spin as the main factor that governs the jet power. By comparing the jet power to characteristic GRB luminosities, we find that the majority of BHs associated with jets are likely born slowly spinning with a dimensionless spin of a ≃ 0.2, or a ≃ 0.5 for wobbling jets, with the main uncertainty originating in the unknown γ-ray radiative efficiency. This result could be applied to the entire core-collapse BH population, unless an anticorrelation between the stellar magnetic field and angular momentum is present. In a companion paper, Jacquemin-Ide et al., we show that regardless of the natal spin, the extraction of BH rotational energy leads to spin-down to a ≲ 0.2, consistent with gravitational-wave observations. We verify our results by performing the first 3D general-relativistic magnetohydrodynamic simulations of collapsar jets with characteristic GRB energies, powered by slowly spinning BHs. We find that jets of typical GRB power struggle to escape from the star, providing the first numerical indication that many jets fail to generate a GRB.
The Timeline of Early Lunar Bombardment Constrained by the Evolving Distributions of Differently Aged Melt
Authors: Liu Tiantian , Michael Greg , Wünnemann Kai
Published: July 2023

The timeline of the early lunar bombardment remains unclear. The bombardment rate as a function of time is commonly modeled by three types of shapes: tail-end, sawtooth, and terminal cataclysm. Differently aged melt records the occurrence time of impact events and thus is crucial for constraining the timeline of the early lunar bombardment. Based on a spatially resolved numerical model, we simulate the evolving distribution of differently aged melt with a long-term impact mixing, where different shapes of impact rate function are considered. We compare the outcome of melt age distribution from different scenarios with the actual data from the lunar meteorites and the returned samples. The results suggest that, if the present data are representative of the melt age distribution on the Moon, the shape of the impact rate function is more likely comparable to the tail-end over the sawtooth and the terminal cataclysm, with the terminal cataclysm being least likely. In addition, using state-of-the-art U–Pb dating techniques, more abundant ancient basin melt is likely to be found in returned samples.
Picking pearls from the Silk Road: Insights into the spider (Arthropoda, Araneae) diversity in Georgia from the CaBOL project. Part I
Authors: Seropian Armen , Otto Stefan , Bulbulashvili Natalia
Published: July 2023

Spiders collected during field trips and by spontaneous hand-collecting throughout Georgia between the years 2006 and 2022 were determined to species level and partly characterized by genetic barcoding of the COI gene. Among the resulting 51 species, two are recorded for the first time from the entire Caucasus Ecoregion: Pireneitega armeniaca (Brignoli, 1978) (Agelenidae) and Leviellus caspicus (Simon, 1889) (Araneidae). Five species are reported for the first time from Georgia: Lycosoides coarctata (Dufour, 1831) (Agelenidae), and from the Araneidae: Aculepeira talishia (Zawadsky, 1902), Gibbaranea gibbosa (Walckenaer, 1802), G. omoeda (Thorell, 1870), Leviellus stroemi (Thorell, 1870) and Singa semiatra L. Koch, 1867. Additionally, Lycosoides lehtineni Marusik & Guseinov, 2003 syn. nov. is synonymized with Lycosoides coarctata (Dufour, 1831). Diagnostic drawings and photographs are provided.
Itineraries of the Working Group for Vegetation Science of the Italian Botanical Society – 1 (2022): Excursion to the Egadi Islands, Mount San Giuliano and Mount Cofano (Trapani, western Sicily, Italy)
Authors: Gianguzzi Lorenzo , Guarino Riccardo , Bazan Giuseppe , Di Pietro Romeo , Acosta Alicia Teresa Rosario , Bajona Enrico , Bolliger Peter , Bonomi Costantino , Camuffo Adriano , Console Carlo , Fascetti Simonetta , Fortini Paola , Frattaroli Annarita , Mei Giacomo , Mondello Fabio , Olivari Silvia , Rizzieri Masin , Rosati Leonardo , Sarmati Simona , Scuderi Leonardo , Simonazzi Marco , Spampinato Giovanni , Viegi Lucia , Stinca Adriano
Published: July 2023

The results of the annual excursion of the Working Group for Vegetation Science of the Italian Botanical Society, held in the Egadi Islands, Mount San Giuliano and Mount Cofano (W Sicily) on April 23–27 2022, are presented. This paper includes: (1) general information on the visited sites; (2) geology and geomorphology; (3) climatology and bioclimatology with tables of climatic data; (4) description of the following five geobotanical itineraries – accompanied by 29 original vegetation relevés and 11 synthetic relevés, proceeding from different bibliographic references: (a) Mount San Giuliano; (b) Marettimo Island: coastal and sub-coastal stretch of the southern part, between Punta Bassana and Contrada Chiappera; (c) Marettimo Island: Case Romane, Mount Pizzo Falcone and the north-western coastal stretch; (d) Island of Levanzo; (e) Mount Cofano – with catenal pictograms of the vegetation, surveys and description of the plant communities and related syntaxonomic scheme; (5) list of the surveyed plant taxa, collected specimens and herbaria in which they are deposited. A new syntaxon is also described (Catapodio pauciflori-Moraeetum sisyrinchii ass. nova), referring to an ephemeral dry grassland located along the north-western coastal stretch of Marettimo. The new association is framed in the Plantagini-Catapodion balearici, alliance of the Stipo-Bupleuretalia semicompositi order of the class Stipo-Trachynietea distachyae (order Stipo-Bupleuretalia semicompositi, alliance Plantagini-Catapodion balearici). An original synoptic table, regarding 17 different plant communities with high frequency of Moraea sisyrinchium, provides a comparative framework of the new association with allied vegetation units so far described throughout the Mediterranean region. Syntaxonomical and nomenclatural remarks regarding the Mediterranean vegetation occurring in this territory are also given throughout the text. Some floristic updates for the study sites are also reported, including the discovery for the first time in Sicily of Lysimachia loeflingii.