bluuebunny/crossref_metadata_2025 huggingface dataset:
Нічна полісомнографія у хворих у гострому періоді закритої черепно-мозкової травми, обумовленої вибуховою хвилею
Authors: Bovt Yu.V. , Zabrodina L.P. , Kas Yu.V. , Korshnyak V.O. , Sukhorukov V.I.
Published: October 2018

Вивчено порушення структури нічного сну у хворих у гострому періоді закритої черепно-мозкової травми, обумовленої вибуховою хвилею. Виявлено, що порушення сну відмічається в 100 % хворих у гострому періоді черепно-мозкової травми, обумовленої вибуховою хвилею. Порушення сну в даних пацієнтів характеризується скороченістю циклів та стадій глибокого нічного сну, що може бути одним із критеріїв подальшого прогнозу клінічної картини перебігу захворювання.
Цукровий діабет і мозковий інсульт: сучасний погляд на проблему
Authors: Pashkovska N.V. , Pashkovskyy V.M.
Published: October 2018

У статті подані сучасні відомості щодо епідеміології й чинників ризику гострих порушень мозкового кровообігу у хворих на цукровий діабет. Наведені дані літератури про можливі механізми розвитку діабетичних церебральних порушень. Розкриті питання діагностичних особливостей, диференціальної діагностики, лікування й профілактики мозкових інсультів у хворих на цукровий діабет згідно із сучасними клінічними настановами.
Рання та відстрочена реакція білка Hif-1α в полях гіпокампа на ішемію-реперфузію в щурів зі стрептозотоцин-індукованим цукровим діабетом
Authors: Boychuk T.M. , Tkachuk S.S. , Nika O.M.
Published: October 2018

Актуальність. Роль транскрипційного фактора Hif-1α в патогенезі гіпоксичних ушкоджень та цукрового діабету (ЦД) доведена, однак молекулярні механізми, що лежать в основі дисфункції даного фактора при поєднанні ЦД з ішемічно-реперфузійним ушкодженням головного мозку, залишаються нез’ясованими. Мета. Вивчення вмісту білка Hif-1α в нейронах полів гіпокампа щурів з експериментальним ЦД у динаміці ішемічно-реперфузійного ушкодження головного мозку. Матеріали та методи. Дослідження виконано на 6-місячних щурах, яким у віці два місяці моделювали ЦД однократним уведенням стрептозотоцину (60 мг/кг маси тіла) (Sigma, США). Порушення мозкового кровообігу відтворювали шляхом оклюзії обох сонних артерій протягом 20 хвилин. Уміст білка Hif1-α визначали методом імунофлуоресценції після 20-хвилинної ішемії з одногодинною реперфузією та на 12-ту добу постішемічного періоду в полях гіпокампа СА1, СА2, СА3, СА4. Результати. У щурів без ЦД 20-хвилинна ішемія з одногодинною реперфузією підвищує вміст білка Hif-1α в усіх досліджених полях гіпокампа. На 12-ту добу ішемічно-реперфузійного періоду в полях гіпокампа СА2-СА4 значення окремих досліджених показників активності транскрипційного фактора Hif-1α продовжують зростати, а в полі СА1 — нормалізуються або наближаються до значень у тварин конт­рольної групи. У щурів із ЦД у ранньому постішемічному періоді в полі СА1 зміни вмісту білка Hif-1α відсутні, в полі СА2 наявні ознаки зниження його активності, в полі СА3 — обмежені реакцією одного показника, в полі СА4 мають такий же характер, як і в контрольних щурів, за даних експериментальних умов. На 12-ту добу ішемічно-реперфузійного періоду в полі СА1 зростають усі показники активності транскрипційного фактора Hif-1α, за абсолютними значеннями перевищуючи відповідні у тварин контрольної групи за тих же експериментальних умов; в полі СА2 і СА3 зміни досліджених параметрів обмежені порівняно з такими у тварин групи контролю; в полі СА4 знижуються показники, які у тварин групи контролю зазнали зростання. Висновки. ЦД обмежує реакцію білка Hif-1α на ішемію-реперфузію в нейронах полів СА1-СА3 у ранньому ішемічно-реперфузійному періоді та в нейронах полів СА2-СА4 — на 12-ту добу спостереження.
Застосування антиоксидантного препарату Гепавал у раціональній терапії цукрового діабету
Authors: Pankiv V.І. , Pankiv І.V.
Published: October 2018

У лекції наведені сучасні дані щодо стану проблеми цукрового діабету й ролі оксидативного стресу. При цукровому діабеті створюються ідеальні умови для розвитку оксидативного стресу, основну роль у якому відіграє перекисне окислення ліпідів. Саме оксидативний стрес становить основу судинних ускладнень і уражає бета-клітини, що призводить до прогресування захворювання. Раннє виявлення ознак оксидативного стресу та його корекція є пріоритетними завданнями предикативної й профілактичної медицини.
Ендометріоз, асоційований із безпліддям: інтеракція імуноендокринних порушень (огляд літератури)
Authors: Koval H.D.
Published: October 2018

Ендометріоз (ендометріоїдні гетеротопії) — це патологічний процес, при якому в міометрії чи інших органах статевої системи і поза нею виникають вогнища, структура яких характеризується наявністю епітеліальних і стромальних елементів, властивих ендометрію. Патогенез ендометріозу та асоційованого з ним безпліддя вважається нез’ясованим. Однак більшість науковців сходяться на думці, що в будь-якому разі можливість ектопічного зростання ендометрію може бути за двох умов: при здатності ендометрію до проліферації поза межами фізіологічної локалізації з подальшою інфільтрацією в підлеглу тканину (наприклад, строму очеревини) та за наявності особливих умов для його функціонування в середовищі нової локалізації — відповідного гормонального фону та необхідних ростових факторів. Усі ці процеси регулюються при розвитку захворювання. Робота виконувалася шляхом огляду публікації баз даних PubMed, Medline за останні десятиліття.
Звернення головного редактора
Authors: Pankiv V.I.
Published: October 2018

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Остеопороз при злоякісних новоутвореннях
Authors: Povoroznyuk V.V. , Bystrytska M.A. , Musiienko A.S.
Published: October 2018

У пацієнтів на тлі онкологічної патології як результат впливу на кісткову тканину пухлинного процесу та протипухлинного лікування (хіміотерапія, променева терапія, андрогенна або естрогенна депривація) і супутньої терапії нерідко розвивається остеопороз. У статті висвітлені останні дані літератури щодо остеопорозу при онкологічній патології та виділені кілька загальних рекомендацій ведення цієї категорії пацієнтів. Наведений клінічний випадок метастатичного пошкодження хребта в пацієнтки з остеопорозом.
Обращение главного редактора
Authors: Ivanov D.D.
Published: October 2018

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Особливості клінічних проявів та перебігу кору
Authors: Trykhlib V.I. , Shchur A.B. , Hrushkevych V.V. , Hryshyn O.S. , Pavlovska M.O. , Musiienko T.I. , Muzyka A.A. , Ralets N.V. , Dudar D.M. , Kozachenko L.V.
Published: October 2018

Проведено огляд літератури стосовно особливостей клінічних проявів, перебігу кору за останні роки під час епідемії у країнах Європи, а також подано результати особистих досліджень щодо хворих, які лікувались у лікувальних закладах України.
Інфекційні захворювання, пов’язані із землетрусами
Authors: Trykhlib V.I. , Maidaniuk V.P. , Nevmerzhytskyi S.O.
Published: October 2018

Проведено огляд літератури стосовно інфекційних захворювань, підвищення рівня захворюваності на які було пов’язане із землетрусами.
Особливості перебігу токсокарозу в дітей
Authors: Sorokman T.V. , Perkas I.
Published: October 2018

Актуальність. Недостатня поінформованість лікарів, в першу чергу педіатрів, про особливості клінічної картини та можливості лабораторної діагностики токсокарозу призводить до пізньої діагностики. Найчастіше токсокароз реєструється під різними діагнозами: алергоз, хронічна пневмонія, дерматит тощо. Мета: вивчити частоту та особливості клінічного перебігу токсокарозу в дітей. Матеріали та методи. Впродовж 2010–2017 рр. обстежено 180 дітей віком від 2 до 16 років із діагнозом «токсокароз». Групу порівняння становили 50 дітей із серонегативною відповіддю в імуноферментному аналізі на токсокароз. Проводилось комплексне обстеження з використанням тест-системи RIDASCREEN® Toxocara IgG, R-Biopharm (Німеччина). Статистичну обробку отриманих результатів проводили з використанням критерію Стьюдента за допомогою комп’ютерної програми Microsoft Statistica, Statson, версія 6.0. Результати. У структурі паразитозів за останні 7 років переважає ентеробіоз (98 %), рідше виявляються аскаридоз (1,5 %) і токсокароз (0,4 %), на частку інших гельмінтозів припадає 0,1 %. У 125 (69,4 %) дітей, хворих на токсокароз, відзначені геофагія та/або наявність собаки. Перевірка на гендерну залежність хворих на токсокароз виявила переважання хлопчиків — 80 (64 %). Найчастіше токсокари виявлялися у віковій групі від 5 до 7 років. Основними клінічними проявами токсокарозу в дітей були диспептичний, астеноневротичний, шкірно-алергічний і респіраторний синдроми. У всіх пацієнтів із токсокарозом визначалися антитіла, гіпохромна анемія, лейкоцитоз, ­еозинофілія. Майже в половини хворих на токсокароз дітей спостерігали зміни з боку гепатобіліарної системи (підвищення лужної фосфатази, диспротеїнемія, гіперферментемія) з високими титрами антитіл до токсокар, гепатомегалією, неоднорідністю ехоструктури печінкової тканини, трифазним типом кровотоку при дуплексному дослідженні та функціональними порушеннями біліарного тракту. Висновки. Встановлено відносно високу частоту токсокарної інвазії серед дітей, ключові фактори ризику інфікування (геофагія та/або контакт із собакою), поліморфізм клінічної маніфестації хвороби.
Acute Kidney Injury among Hospitalized Children in China
Authors: Xu Xin , Nie Sheng , Zhang Aihua , Mao Jianhua , Liu Hai-Peng , Xia Huimin , Xu Hong , Liu Zhangsuo , Feng Shipin , Zhou Wei , Liu Xuemei , Yang Yonghong , Tao Yuhong , Feng Yunlin , Chen Chunbo , Wang Mo , Zha Yan , Feng Jian-Hua , Li Qingchu , Ge Shuwang , Chen Jianghua , He Yongcheng , Teng Siyuan , Hao Chuanming , Liu Bi-Cheng , Tang Ying , He Wenjuan , He Pinghong , Hou Fan Fan
Published: October 2018

Background and objectives

High-quality epidemiologic data on AKI in children are particularly lacking in developing countries. This study aimed to assess the epidemiology and clinical correlates of AKI among hospitalized children in China.

Design, setting, participants, & measurements

We performed a multicenter study, in a cohort of hospitalized children aged 1 month to 18 years, from 25 general and children’s hospitals in China during 2013–2015. We obtained patient-level data from the electronic hospitalization information system and laboratory databases of all children who had at least two serum creatinine tests within any 7-day window during their first 30 days of hospitalization. We identified AKI events according to the creatinine criteria of Kidney Disease Improving Global Outcomes. The in-hospital outcomes of AKI, including mortality, kidney recovery, and length of stay, were assessed. We estimated the corresponding hazard ratios using a Cox proportional hazard model, with adjustment for age, sex, comorbidities, and clinical procedures.

Results

A total of 19,908 (20%) patients with AKI were identified among 101,836 pediatric inpatients, of which 7220 (7%) were community acquired and 12,688 (13%) were hospital acquired. Up to 96% of these AKI events were not diagnosed on the discharge records. The cumulative incidence of AKI in infants (28%) was twice that in adolescents (12%). The profiles of risk factors differed between community-acquired and hospital-acquired AKI and varied with age. Diarrhea and sepsis were the top risk factors for community-acquired AKI, each contributing 6% of the risk. Congenital heart disease/cardiac surgery was the major risk factor for hospital-acquired AKI, contributing to 19% of cases. Exposure to nephrotoxic drugs, mostly nonsteroidal anti-inflammatory drugs and proton pump inhibitors, was common in hospitalized children and was associated with a higher risk of AKI. Death occurred in 842 out of 19,908 patients (4%) with AKI versus 450 out of 81,478 children (0.5%) without AKI. The risk of in-hospital death was higher among children with severe AKI, shock, and respiratory failure. Pediatric AKI was associated with longer hospital stay and higher daily cost, even after adjustment for covariates.

Conclusions

Pediatric AKI is common and is substantially underdiagnosed in China.
HISTORIC REVIEW ON MODERN HERBAL NANOGEL FORMULATION AND DELIVERY METHODS
Authors: Baskar Viswanathan , I. Salim Meeran , A. Subramani , . Sruthi , Ali Jawahar , K. Shabeer T.
Published: October 2018

Chemistry deals with herbal constituents are often coined as phytochemistry. Herbal constituents have profound improvements in drug discovery for several existing diseases. Many of these constituents are restricted from pharmaceutical discoveries due to two important reasons: pharmacodynamics and pharmacokinetics. There are many new technological strategies and comparisons have been studied to improve the herbal discoveries in the pharmaceutical market. This review paper will highlight historical evidence of nanogels which is the most important strategy applied to several herbal medicines with high patience compliance, delivery rate, and efficiency. Nanogels are nanoparticles combined with cross-linked polymer networks with desirable features to carry hydrophilic or hydrophobic drugs in a more stable condition. Nanogels are highly preferred substances for herbal medicine in terms of stability and rapid response to the external stimuli factors. Nanogel can facilitate the herbal products with higher cellular penetration than existing and hence, it proves to be the new dimension for both oral and transdermal drug delivery for several unmet diseases like cancer, diabetes, and chronic disorders. By the way, including the recent technological constituents to herbal drugs, it can possess high bioavailability, low toxicity and enhance the sustained release mechanism with suitable delivery modes.
EVALUATION OF THE EFFICACY OF A HYDROGEN PEROXIDE DISINFECTANT
Authors: Medina-cÓrdoba Luz Karime , Valencia-mosquera Ligia Lucia , Tarazona-diaz Gretty Paola , Arias-palacios Janeth Del Carmen
Published: October 2018

Objective: To evaluate the efficacy of a disinfectant based on hydrogen peroxide.Methods: The method used to assess the efficacy of the disinfectant was the agar plate technique. With this procedure, it was possible to determine the percentage of inhibition of the high-level disinfectant of STERIS against four microorganisms, i.e., Pseudomonas aeruginosa ATCC 9027, Staphylococcus aureus (Beta-Hemolytic 227), Salmonella choleraesuis (Kuznedorf CMDM 074), and Bacillus subtilis (ATCC 6633). The effectiveness of five disinfectant concentrations (0.02%, 0.04%, 0.08%, 1%, and 2%) was determined and evaluated in three different times 5, 10, and 15 min, for vegetative strains and 3, 6, and 9 h for the sporulated strain.Results: According to the experimental test, the reduction of the microbial population was, on average, 100% for the disinfectant concentrations of 0.08%, 1%, and 2%.Conclusion: The results obtained demonstrated that the high-level disinfectant of STERIS based on hydrogen peroxide is 100% effective when the concentration recommended by the commercial house (2%) is used in the shortest time exposure to disinfectant. The minimum level of effectiveness was 0.08%; however, if lower concentrations are used, destruction of the microorganisms is not guaranteed.
ESTIMATION OF CELECOXIB IN HUMAN PLASMA BY RAPID AND SELECTIVE LC-MS/MS METHOD FOR A BIOEQUIVALENCE STUDY
Authors: Patel Nirav P. , Sanyal Mallika , Shrivastav Pranav S. , Patel Bhavin N.
Published: October 2018

Objective: A selective, sensitive and rapid liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay has been developed for the determination of celecoxib (CXB) in negative ionization mode.Methods: Celecoxib and celecoxib-D7 (CXB-D7) as internal standard (IS) were extracted from 300 µl human plasma by solid-phase extraction using strata-X SPE cartridges. Chromatographic separation was achieved on ACE C8-300 (50 × 4.0 mm, 3.0 μm) column using methanol-1.0 mmol ammonium acetate solution in 80:20 (v/v) ratio. The protonated precursor to product ion transitions studied for CXB and CXB-D7 were m/z 380.0 → 315.9 and 387.0 → 323.0, respectively.Results: The limit of detection (LOD) and lower limit of quantitation of the method were 2.50 and 10.0 ng/ml respectively with a linear dynamic range of 10.0-4000 ng/ml for CXB. The intra-batch and inter-batch precision (% CV) and mean relative recovery across quality control levels is<7.2 % and 85.5 % respectively. Matrix effect in human plasma, expressed as IS-normalized matrix factor ranged from 0.99-1.03.Conclusion: The method was successfully applied in healthy subjects using a single dose of 400 mg celecoxib capsules under fasting and fed conditions. The reproducibility in the measurement of study data is demonstrated by incurred sample reanalysis.
A NOVEL HPTLC METHOD FOR SIMULTANEOUS DETERMINATION OF CO-ENZYME Q10 AND α-TOCOPHEROL IN BULK AND PHARMACEUTICAL FORMULATION
Authors: Kulkarni Manasi B. , Joshi Anagha M. , Patil Rohini V.
Published: October 2018

Objective: HPTLC Method for Simultaneous quantification of co-enzyme Q10 and α-tocopherol in bulk and capsule dosage form was developed and validated as per International Conference on Harmonization [(ICH) Q2 (R1)] guideline.Methods: The chromatograms were developed using a mobile phase of Toluene: ethyl acetate: chloroform (10:1:2 v/v/v) on Pre-coated silica 60F 254 plates and quantified by densitometric absorbance mode at 280 nm.Results: The Rf values were 0.77 and 0.87 for co-enzyme Q10 and α-tocopherol, respectively. The linearity of the method was found to be in the concentration range of 0.6µg-1.8 µg/band for α-tocopherol and 2 µg-6 µg/band for co-enzyme Q10. The limits of detection and quantification were 0.3154 and 0.9559 µg/band for α-tocopherol and 3.441 and 10.42 µg/band for co-enzyme Q10.Conclusion: Developed densitometric method was found to be robust, precise, accurate, and rapid and can be used to analyse fixed-dose capsule samples of co-enzyme Q10 and α-tocopherol.
Predicting Pork Color Scores Using Computer Vision and Support Vector Machine Technology
Authors: Sun Xin , Young Jennifer , Liu Jeng Hung , Chen Quansheng , Newman David
Published: October 2018

The objective of this study was to investigate the ability of image color features to predict subjective pork color scores. Subjective and instrumental color were assessed on the bloomed, cross-sectional surface of pork longissimus thoracis et lumborum chops. Images of pork chop samples were acquired using a computer vision system, and 18 image color features (mean and standard deviation of R, G, B, H, S, I, L*, a*, b*) were extracted for inclusion in partial least squares (PLS) and support vector machine (SVM) regression models. For color scores 2, 3, 4, and 5, the accuracies were 50.4, 75.9, 72.4, and 47.3% classified correctly by PLS, respectively, and 70.7, 72.8, 76.7, and 69.7% by SVM, respectively. The overall prediction accuracies of 2 models for pork color scores were 68.3% for PLS and 73.4% for SVM. There was minimal major misclassification of samples (< 0.5%). Image color features isolated through the development of PLS and SVM models, particularly SVM, show potential as a method to predict pork color scores.
The US Healthcare Facilities Management Industry's State of Hiring from Facilities Management Academic Programs
Authors: Call Steven , Sullivan Kenneth , Smithwick Jake
Published: October 2018

The purpose of this research is to better understand the current state of US healthcare FM industry hiring practices from FM academic programs. A national survey was distributed to healthcare FM directors to collect quantifiable information on healthcare organizations and their hiring practices from FM academic programs. Survey respondents that hired directly from an academic program were contacted for phone interviews. Results indicate that the healthcare FM industry is hiring very few college interns and new college graduates for entry-level management jobs. This paper is valuable in establishing the current state of the US healthcare industry's hiring practices from FM academic programs. Results will be used to better understand the needs and barriers of entry-level FM employment from FM academic programs as a potential source for new talent to the healthcare FM industry.
Vasculitis primaria del sistema nervioso central, un reto diagnóstico. Reporte de caso
Authors: Silva Soler Miguel Arturo , Quintero Ana María , González Aura Virginia
Published: October 2018

La angeítis primaria del sistema es una rara entidad, en la cual hay destrucción y compromiso inflamatorio de los vasos del sistema nervioso central. Con frecuencia, es subdiagnosticada por sus múltiples formas de presentación clínica y por los hallazgos en neuroimágenes que pueden simular otras patologías, lo que retrasa el diagnóstico y el manejo oportuno. Este tipo de vasculitis es muy poco comprendida y no existen suficientes estudios en la actualidad respecto a su fisiopatología y manejo. Los marcadores inflamatorios suelen ser normales, con alteración del LCR en un 80-90 % de los casos y la arteriografía cerebral puede mostrar un patrón típico descrito como áreas alternantes de dilatación y estenosis; sin embargo, con muy baja sensibilidad. Ante una alta sospecha clínica y ausencia de pruebas diagnósticas no invasivas, el diagnóstico se realiza a través de biopsia de las lesiones cerebrales y meninges. Finalmente, el tratamiento se basa en combinación de corticoides y ciclofosfamida, aunque se carece de estudios controlados que lo soporten.
Tratamiento endovascular de aneurisma disecante de la arteria basilar con dispositivo redireccionador de flujo FRED: primer reporte de caso en Colombia
Authors: Peñarete Nader Rafael , Cifuentes Jorge , Castro Jiménez Mayte , Hernández Alfredo , Duque Guidales Laura
Published: October 2018

INTRODUCCIÓN:
Los aneurismas disecantes de la arteria basilar tienen un curso clínico impredecible que, eventualmente, evoluciona a un accidente cerebrovascular hemorrágico o isquémico grave. Por otro lado, su abordaje terapéutico es controvertido y no existen líneas claras de tratamiento.

CASO CLÍNICO:
Presentamos el caso de una mujer de 28 años con un infarto del tallo cerebral secundario a aneurisma disecante de la arteria basilar, tratado exitosamente con dispositivo endoluminal redireccionador de flujo (FRED).

CONCLUSIÓN:
El tratamiento endovascular con FRED de los aneurismas disecantes parece ofrecer ventajas sobre las técnicas quirúrgicas abiertas y stents tradicionales, en casos seleccionados.
Pemahaman dan Penerapan Sistem Among Ki Hadjar Dewantara pada Usia Wiraga
Authors: Susanto Yenita Heri , Jaziroh Amnahul
Published: October 2018

Pendidikan anak usia dini merupakan pendidikan yang fundamental karena masa  awal anak mulai mengenyam pendidikan. Menurut sistem among Ki Hadjar Dewantara, anak usia dini dikategorikan dalam usia “Wiraga”. Tujuan penelitian ini untuk mengetahui pemahaman dan penerapan sistem among Ki Hadjar Dewantara pada usia wiraga. Metode penelitian ini yaitu kualitatif dengan pendekatan studi kasus. Teknik pengumpulan data dilakukan dengan observasi dan wawancara kepada kepala sekolah dan 3 guru Sekolah Alam Ramadhani Kediri. Hasil penelitian meliputi: Pemahaman sistem among ialah seorang guru mendampingi, melayani, mengingatkan, serta sebagai seorang teman. Usia wiraga dipahami sebagai usia 0-8 tahun, dimana anak banyak bermain dan olah gerak (motorik kasar). Sistem among di Sekolah Alam Ramadhani diterapkan sesuai dengan kondisi dan tugas perkembangan anak  pada usia yang dia miliki.  Pendidikan bagi anak usia dini  seharusnya  bersifat memerdekakan anak selama tidak membahayakan dirinya sehingga sistem among dapat dijadikan sebagai suatu sistem yang tepat bagi pendidikan anak usia dini.Kata kunci : anak usia dini, sistem among, ki hadjar dewantara
Students’ Motivation and Preferences toward Native and Non-native English Speaking Teachers
Authors: Adara Reza Anggriyashati
Published: October 2018

There is a notion that teachers are one of important factors which motivate students to learn English. The present study aims to investigate students’ motivation in learning English with Native English Speaking Teachers (NEST) and Non-native English Speaking Teachers (NNEST) and whether the students are more motivated to learn English with NEST or NNEST. Furthermore, this study examines students’ preferences regarding NEST and NNEST. To obtain the findings, mixed method research was conducted. A set of questionnaires were distributed to thirty students in a private junior high school in Bekasi, Indonesia whereas semi-structured interviews were conducted to two students of same school. The findings show that teacher is an influential factor that motivates students to learn English. Although the respondents are more motivated to learn English from NEST, they do not have certain preferences regarding NEST and NNEST as both teachers help the respondents to learn English in different ways. The findings reveal that NEST are considered better in vocabulary teaching while NNEST teach grammar better.
THE CONTRIBUTIONS OF TOURISM INDUSTRY TOWARD STUDENTS’ SPEAKING MOTIVATION IN LEARNING ENGLISH
Authors: Umar Umar , Suparman Suparman
Published: October 2018

This research aimed to find out The Contributions of Tourism Industry toward Students’ Speaking Motivation in Learning English on Students who live around Tourism Object. The participants of this research proposal is the students who live around tourism object (case study at Kencana Beach Cottages in Labuhan Badas Sumbawa Besar). The present study used mixed method. It contain to be examined in relation to quantitative and qualitative methods of data collection and analysis. The instrument used in collecting data was questionnaire, speaking test and observation.  Questionnaire and speaking test used descriptive statistics of frequencies and percentages. It was analyzed by using SPSS Program.Observation was analyzed by using qualitative method. Based on the data analysis technique above, it was found out the the contributions oftourism industry toward students’ speaking motivation in learning English and to know how the contribution of tourism industry toward students’ speaking motivation in English.
ANALYSIS WORD CLASSES IN SELECTED POEMS BY ALLAN ALEXANDER MILNE
Authors: Nopikasari Nora , Safitri Ani , Suhandi Agung
Published: October 2018

The objectives of this study are to investigate the word class or known as part of speech from the chosen poems of Alan Alexander Milne. For that reason, five poems of him are analyzed: Wrong House, Furry Bear, If I Were King, The Mirror, dan Hoppity. This study applies descriptive qualitative methods. The procedure of the study covers several steps; dividing words into word class category, analyzing them statistically and reporting the result. Out of the five analyzed poems, there are three-word class categories; verb, noun, an adjective. The most dominant used word class in the poems is noun comprising of 105 in total . This is due to the fact that noun is what the students most widely learned as beginner learners. In these poems, the noun describes the meaning of the poems. Therefore; the categorizing of the part of speech is important to enrich vocabulary and ease the understanding of the poem. This analysis is to make the readers easier in understanding the word class using a poem by Alan Alexander Milne
Reverse-Phase Chromatographic Determination and Intrinsic Stability Behavior of 5-[(4-Chlorophenoxy)Methyl]-1,3,4-Oxadiazole-2-Thiol
Authors: Shehzadi Naureen , Hussain Khalid , Islam Muhammad , Bukhari Nadeem Irfan , Khan Muhammad Tanveer , Salman Muhammad , Siddiqui Sabahat Zahra , Rehman Aziz-Ur , Abbasi Muhammad Athar
Published: October 2018

The study describes the development and preliminary validation of a simple reverse-phase chromatographic method for determination of a novel drug candidate, 5-[(4-chlorophenoxy) methyl]-1,3,4-oxadiazole-2-thiol (OXCPM), in bulk and stressed solution, in order to find out the intrinsic stability behavior of the compound. Isocratic elution was carried out at a flow rate of 1.0 mL min-1 through a Promosil C18 column maintained at 25 °C, using the mobile phase comprising acetonitrile and aqueous o-H3PO4 (pH 2.67) (1:1, V/V). Detection was performed at 258 nm. The response of the detector was linear in a concentration range of 1.25-50.00 μg mL-1 with the correlation coefficient of 0.9996 ± 0.0001. Cumulative intra-day, inter-day and inter-instrument accuracy (99.5 ± 1.0, 100.2 ± 1.0 and 100.3 ± 0.4 %, resp.) with RSD less than 5 % indicated that the method was accurate and precise. The resolution and selectivity factor (>2 and >1, resp.), particularly in copper metal- and dry-heat-stress solutions, depicted the selectivity of the method. OXCPM remained stable under hydrolytic (acidic and neutral pH, ≤ 37 °C), photolytic and moist heat stress conditions. Under alkaline conditions (hydrolytic and photolytic), polar products were formed that eluted very fast through the column (tR < 3.75 min). At room temperature, the compound was susceptible to oxidation by hydrogen peroxide and transition metals. The ionogram of most of the stress solutions indicated the presence of a product having m/z 256, which might be a result of N- or Smethylation or -SH oxidation. The results of the study indicate that the method is selective, sensitive and suitable to be used for determination of OXCPM in bulk and under stress conditions.
Acalypha Wilkesiana ‘Java White’: Identification of Some Bioactive Compounds by Gc-Ms and Their Effects on Key Enzymes Linked to Type 2 Diabete
Authors: Oyebode Olajumoke A. , Erukainure Ochuko L. , Koorbanally Neil A. , Islam Md. Shahidul
Published: October 2018

In this study, we identified bioactive compounds from the ethanolic extracts of the leaves, stem bark and root bark of Acalypha wilkesiana through GC-MS analysis and investigated the effects of these extracts on some of the enzymes linked to type 2 diabetes. Plant parts were extracted sequentially with ethyl acetate, ethanol and water. GC-MS analysis revealed the presence of long-chain alkyl acids, esters, ketones and alcohols including phytol and phytol acetate along with some secondary metabolites such as xanthone, vitamin E and various types of sterols including stigmasterol, campesterol and sitosterol. Ethanolic extracts of all the parts showed a dose- -dependent inhibition of α-glucosidase and α-amylase activity. The extracts also demonstrated anti-lipase activity. The ethanolic extract of root bark showed the highest inhibition of enzymes compared to other extracts. The EC50 values (concentrations for 50 % inhibition) of α-glucosidase, α-amylase and lipase inhibition were 35.75 ± 1.95, 6.25 ± 1.05 and 101.33 ± 5.21 μg mL-1, resp. The study suggests that A. wilkesiana ethanolic extracts have the ability to inhibit the activity of enzymes linked to type 2 diabetes. Further studies are needed to confirm the responsible bioactive compounds in this regard.
Chloroquine Urea Derivatives: Synthesis and Antitumor Activity in Vitro
Authors: Pavić Kristina , Rajić Zrinka , Mlinarić Zvonimir , Uzelac Lidija , Kralj Marijeta , Zorc Branka
Published: October 2018

In the current paper, we describe the design, synthesis and antiproliferative screening of novel chloroquine derivatives with a quinoline core linked to a hydroxy or halogen amine through a flexible aminobutyl chain and urea spacer. Synthetic pathway leading to chloroquine urea derivatives 4-10 includes two crucial steps: i) synthesis of chloroquine benzotriazolide 3 and ii) formation of urea derivatives through the reaction of compound 3 with the corresponding amine. Testing of antiproliferative activity against four human cancer cell lines revealed that chloroquine urea derivatives 9 and 10 with aromatic moieties show activity at micromolar concentrations. Therefore, these molecules represent interesting lead compounds that might provide an insight into the design of new anticancer agents.
Yesterday masked, today modified; what do mycotoxins bring next?
Authors: Kovač Marija , Šubarić Drago , Bulaić Mateja , Kovač Tihomir , Šarkanj Bojan
Published: October 2018

Mycotoxins are secondary metabolites produced by toxigenic fungi in crops worldwide. In (micro)organisms such as plants, fungi, bacteria, or animals they may be further metabolised and modified, but this is also true for food processing, which may lead to a wide range of masked mycotoxin forms. These often remain undetected by analytical methods and are the culprits for underestimates in risk assessments. Furthermore, once ingested, modified mycotoxins can convert back to their parent forms. This concern has raised the need for analytical methods that can detect and quantify modified mycotoxins as essential for accurate risk assessment. The promising answer is liquid chromatography-mass spectrometry. New masked mycotoxin forms are now successfully detected by iontrap, time-of-flight, or high-resolution orbitrap mass spectrometers. However, the toxicological relevance of modified mycotoxins has not been fully clarified.
Whole blood exchange transfusion as a promising treatment of aluminium phosphide poisoning
Authors: Zamani Nasim , Hassanian-Moghaddam Hossein , Ebrahimi Sakine
Published: October 2018

A 37-year-old male was referred to us about one hour after deliberate ingestion of two 3-gram aluminium phosphide (ALP) tablets. Three hours after admission, his blood pressure dropped to 85/55 mmHg, his heart rate increased to 120 bpm, O2 saturation dropped to 82 %, and the electrocardiogram showed junctional rhythm. We started whole blood exchange, and gross haematuria and jaundice ensued. However, his blood pressure increased, arrhythmia resolved itself, and he was extubated two days after the transfusion was completed. He was sent home seven days after admission completely symptom-free. We believe this treatment may be successfully applied in ALP-poisoned patients.
Bibo Stabilisation of Continuous–Time Takagi–Sugeno Systems under Persistent Perturbations and Input Saturation
Authors: Salcedo José V. , Martínez Miguél , García-Nieto Sergio , Hilario Adolfo
Published: October 2018

This paper presents a novel approach to the design of fuzzy state feedback controllers for continuous-time non-linear systems with input saturation under persistent perturbations. It is assumed that all the states of the Takagi-Sugeno (TS) fuzzy model representing a non-linear system are measurable. Such controllers achieve bounded input bounded output (BIBO) stabilisation in closed loop based on the computation of inescapable ellipsoids. These ellipsoids are computed with linear matrix inequalities (LMIs) that guarantee stabilisation with input saturation and persistent perturbations. In particular, two kinds of inescapable ellipsoids are computed when solving a multiobjective optimization problem: the maximum volume inescapable ellipsoids contained inside the validity domain of the TS fuzzy model and the smallest inescapable ellipsoids which guarantee a minimum *-norm (upper bound of the 1-norm) of the perturbed system. For every initial point contained in the maximum volume ellipsoid, the closed loop will enter the minimum *-norm ellipsoid after a finite time, and it will remain inside afterwards. Consequently, the designed controllers have a large domain of validity and ensure a small value for the 1-norm of closed loop.
A Fast Evaluation of Initial Configurations in Repeatable Inverse Kinematics for Redundant Manipulators
Authors: Duleba Ignacy , Karcz-Duleba Iwona , Mielczarek Arkadiusz
Published: October 2018

A repeatable inverse kinematic task in robot manipulators consists in finding a loop (cyclic trajectory) in a configuration space, which corresponds to a given loop in a task space. In the robotic literature, an entry configuration to the trajectory is fixed and given by a user. In this paper the assumption is released and a new, indirect method is introduced to find entry configurations generating short trajectories. The method avoids a computationally expensive evaluation of (infinite) many entry configurations for redundant manipulators (for each of them, repeatable inverse kinematics should be run). Some fast-to-compute functions are proposed to evaluate entry configurations and their correlations with resulting lengths of trajectories are computed. It appears that only an original function, based on characteristics of a manipulability subellipsoid, properly distinguishes entry configurations that generate short trajectories. This function can be used either to choose one from a few possible entry configurations or as an optimized function to compute the best initial configuration.
An Exact Geometry–Based Algorithm for Path Planning
Authors: Jafarzadeh Hassan , Fleming Cody H.
Published: October 2018

A novel, exact algorithm is presented to solve the path planning problem that involves finding the shortest collision-free path from a start to a goal point in a two-dimensional environment containing convex and non-convex obstacles. The proposed algorithm, which is called the shortest possible path (SPP) algorithm, constructs a network of lines connecting the vertices of the obstacles and the locations of the start and goal points which is smaller than the network generated by the visibility graph. Then it finds the shortest path from start to goal point within this network. The SPP algorithm generates a safe, smooth and obstacle-free path that has a desired distance from each obstacle. This algorithm is designed for environments that are populated sparsely with convex and nonconvex polygonal obstacles. It has the capability of eliminating some of the polygons that do not play any role in constructing the optimal path. It is proven that the SPP algorithm can find the optimal path in O(nnr2) time, where n is the number of vertices of all polygons and n ̓ is the number of vertices that are considered in constructing the path network (n ̓ ≤ n). The performance of the algorithm is evaluated relative to three major classes of algorithms: heuristic, probabilistic, and classic. Different benchmark scenarios are used to evaluate the performance of the algorithm relative to the first two classes of algorithms: GAMOPP (genetic algorithm for multi-objective path planning), a representative heuristic algorithm, as well as RRT (rapidly-exploring random tree) and PRM (probabilistic road map), two well-known probabilistic algorithms. Time complexity is known for classic algorithms, so the presented algorithm is compared analytically.
Linguistically Defined Clustering of Data
Authors: Leski Jacek M. , Kotas Marian P.
Published: October 2018

This paper introduces a method of data clustering that is based on linguistically specified rules, similar to those applied by a human visually fulfilling a task. The method endeavors to follow these remarkable capabilities of intelligent beings. Even for most complicated data patterns a human is capable of accomplishing the clustering process using relatively simple rules. His/her way of clustering is a sequential search for new structures in the data and new prototypes with the use of the following linguistic rule: search for prototypes in regions of extremely high data densities and immensely far from the previously found ones. Then, after this search has been completed, the respective data have to be assigned to any of the clusters whose nuclei (prototypes) have been found. A human again uses a simple linguistic rule: data from regions with similar densities, which are located exceedingly close to each other, should belong to the same cluster. The goal of this work is to prove experimentally that such simple linguistic rules can result in a clustering method that is competitive with the most effective methods known from the literature on the subject. A linguistic formulation of a validity index for determination of the number of clusters is also presented. Finally, an extensive experimental analysis of benchmark datasets is performed to demonstrate the validity of the clustering approach introduced. Its competitiveness with the state-of-the-art solutions is also shown.
On Hyper–Regularity and Unimodularity of Ore Polynomial Matrices
Authors: Fritzsche Klemens , Rӧbenack Klaus
Published: October 2018

We investigate Ore polynomial matrices, i. e., matrices with polynomial entries in d/dt whose coefficients are meromorphic functions in t and as such constitute a non-commutative ring. In particular, we study the properties of hyper-regularity and unimodularity of such matrices and derive conditions which make it possible to efficiently check for these characteristics. In addition, this approach enables computation of hyper-regular left and right and unimodular inverses.
Association of Coronary Wall Shear Stress With Atheromatous Plaque Vulnerability: A Systematic Review
Authors: Benedek Annabella , Opincariu Diana , Benedek Imre , Ferenț Ionuț , Hodaș Roxana , Marton Emese , Benedek Theodora
Published: October 2018

Acute coronary syndromes are usually triggered by the erosion or rupture of a vulnerable coronary plaque. A vulnerable plaque (VP) is an atheromatous plaque which, after suffering different transformations, is prone to rupture causing an acute coronary event. Such a VP carries inside several biomarkers considered as “signatures of vulnerability”, which, if identified, can prompt timely initiation of therapeutic measures in order to prevent the development of an acute myocardial infarction. The most freqeuntly used techniques for identification of vulnerability markers are computed tomographic angiography (CTA), intravascular ultrasound and optical coherence tomography. Endothelial shear stress (ESS) represents a new promising biomarker associated with plaque vulnerability. Determination of ESS is nowadays possible using noninvasive imaging techniques, based on complex computational post-processing of multiple datasets extracted from CTA images and advanced computational fluid dynamics technologies. The aim of this systematic review was to evaluate the role of the coronary ESS, determined using advanced computational techniques for image post-processing, as a feature associated with CTA-derived biomarkers of atheromatous plaque vulnerability, underlining the conceptual differences between high ESS and low ESS as promotors of vulnerability.
Erector Spinae Block. A Narrative Review
Authors: López María Bermúdez , Cadórniga Álvaro Gasalla , González José Manuel López , Suárez Enrique Domínguez , Carballo Carlos López , Sobrino Francisco Pardo
Published: October 2018

The erector spinae plane block is a novel ultrasound-guided technique that has recently been described for the management of acute and chronic thoracic pain. Currently an increasingly number of indications for the ESP block have been published. Nevertheless, the anatomy, mechanism of action, doses and volume of local anesthetic needed are still unclear. The aim of this narrative review is study this new block with base on the updated medical literature.
Primary upper extremity deep vein thrombosis in a Caucasian woman
Authors: Maris Mihaela Ioana , Avram Mihaela Flavia , Muntean Danina Mirela
Published: October 2018

Compared to deep vein thrombosis in the lower limbs, upper extremity deep vein thrombosis is uncommon and therefore much less explored or even neglected.

We present the case of a 40-year-old female working in the bakery industry, who was admitted for acute onset of upper limb oedema accompanied by pain and functional impairment, affirmative secondary to the sustained and intense effort of the dominant arm. The diagnosis was confirmed by Duplex Ultraso nography on the eighth day after the onset of symptoms. Since clinical examinations and laboratory work excluded any cause of secondary thrombosis, the diagnosis of primary thrombosis was established. The only possible cause of this episode was linked to the woman’s work. The trigger for the thrombotic event was represented most likely by strenuous physical activity with temporary obstruction of the thoracic outlet in the work field. Under anticoagulant treatment, the signs and symptoms gradually resolved. Unfortunately, at the one-year follow-up exam, the patient was diagnosed with post-thrombotic syndrome of the right, dominant arm.
Molecular Docking Sianidin dan Peonidin sebagai Antiinflamasi pada Aterosklerosis Secara In Silico
Authors: Saputra Diajeng Putri Dwinda
Published: October 2018

Atherosclerosis is a chronic inflammatory disease that begins with endothelial dysfunction resulting in plaque growth in the inner walls of the arteries. Endothelial dysfunction causes endothelial activates NF-?B resulting in a transcription of proinflammatory gene supporting the growth of atherosclerotic plaque. The purple sweet potato anthocyanin is a compound known to have activity inhibiting the inflammatory process. The major anthocyanins contained in purple sweetpotato are cyanidine and peonidine. The cyanidine and peonidin activity test was performed as antiinflammatory at atherosclerosis based on their interaction on NF-?B protein using molecular docking method in silico. The stages of this research are preparation of protein structure database of NF-?B, protein preparation using Chimera1.10.1 application, preparation and optimization of cyanidin and peonidin 3D structure using HyperChem8 application, and validation of molecular docking and docking method of cyanidin and peonidin on NF-?B protein using application Autodock4.2. The results showed that cyanidine and peonidine had affinity and formed a hydrogen bond with the NF-?B protein. The bond energy between cyanidine and peonidine with the NF-?B protein is -7.92 kcal/mol and -7.86 kcal/mol which together form the hydrogen bond with the LEU472 amino acid on the binding site equal to the native ligand. Cyanidin and peonidine have the potential of activity as antiatherosklerosis because it has an affinity with the NF-?B protein so that it prevents the inflammatory process in the formation of atherosclerotic plaque.
A Graph-Convolutional Neural Network Model for the Prediction of Chemical Reactivity
Authors: Coley Connor W. , Jin Wengong , Rogers Luke , Jamison Timothy F. , S Jaakkola Tommi , Green William H. , Barzilay Regina , Jensen Klavs F.
Published: October 2018

We present a supervised learning approach to predict the products of organic reactions given their reactants, reagents, and solvent(s). The prediction task is factored into two stages comparable to manual expert approaches: considering possible sites of reactivity and evaluating their relative likelihoods. By training on hundreds of thousands of reaction precedents covering a broad range of reaction types from the patent literature, the neural model makes informed predictions of chemical reactivity. The model predicts the major product correctly over 85% of the time requiring around 100 ms per example, a significantly higher accuracy than achieved by previous machine learning approaches, and performs on par with expert chemists with years of formal training. We gain additional insight into predictions via the design of the neural model, revealing an understanding of chemistry qualitatively consistent with manual approaches.