bluuebunny/crossref_metadata_2025 huggingface dataset:
Strategi Komunikasi Pemasaran Telkomsel dalam Meningkatkan Loyalitas Pelanggan
Authors: Tri Hudaya Dedy
Published: September 2023

Internet packages have become a daily necessity and cannot be avoided, especially during the covid 10 pandemic considering that most people carry out teaching and learning activities, offices, business, seminars, workshops by online services and work from home (WFH).Rezeki Combo Sakti package can be purchased and obtained on modern channels such as Alfamart, Indomaret and Alfamidi, where the modern channel has a nationwide network of up to 14,000 outlets. The Combo Sakti package offers competitive prices and data quotas for its customers accompanied by good quality. To make the Combo Sakti package more attractive to customers, program Combo Sakti Rezeki is made for the period October â€“ December 2021 and various prizes are available. The prizes consist of 1 Honda Mobilio car, 4 beat motorbikes, 12 Samsung Galaxy A52 handphone and 30 iSaku vouchers @ IDR 1,000,000 which are drawn every month and the Grand Prize 1 Honda Mobilio.

Abstrak

Paket Internet menjadi suatu kebutuhan harian dan tidak dapat di hindarkan khususnya saat pademi covid 10 mengingat sebagian besar masyarakat melakukan kegiatan belajar mengajar, perkantoran, bisnis, seminar, workshop, pelayanan melalui daring serta work from home (WFH). Paket combo sakti dapat dibeli dan diperoleh di modern channel seperti Alfamart, Indomaret dan Alfamidi yang mana modern channel memiliki jaringan yang tersebar secara nasional hingga 14.000 outlet. Paket Combo Sakti menawarkan harga dan kuota data yang kompetitif bagi pelangganya disertai dengan kualitas yang baik. Agar paket Combo sakti lebih menarik bagi pelanggan maka dibuat suatu program dengan Rezeki Combo Sakti dengan periode Oktober â€“ Desember 2021 serta tersedia berbagai macam hadiah. Hadiahnya terdiri 1 buah mobil honda Mobilio, 4 buah motor beat, 12 Handphone Samsung Galaxy A52 serta 30 voucher iSaku@ Rp 1.000.000 yang mana di undi setiap bulan dan Grand Prizenya berupa 1 Honda Mobilio.
Perancangan Media Promosi Desain Aplikasi Mobile Tentang Tepung Mocaf Pengganti Tepung Terigu Pada UMKM Arum Ayu Healthy Local Food
Authors: Hasian Irene , Segara Adi , Safira Ishma
Published: September 2023

Micro, Small and Medium Enterprises (MSMEs) are a category of small-scale businesses that are believed to be able to contribute to the Indonesian economy. One of the most preferred MSME businesses, even by young people, is the culinary business. One of them is MSME Arum Ayu Healthy Local Food as a supplier of gluten-free cassava flour (mocaf flour) in Tangerang Banten, in addition to selling raw materials for mocaf flour, it also provides a variety of Indonesian food made from tuber flour (gluten-free). Mocaf flour is a modification of cassava flour with a fermentation technique so that the resulting product has characteristics similar to wheat flour, soft white and no cassava taste so that the viscosity is better. Not many people are familiar with mocaf flour and its benefits and this is an obstacle for Arum Ayu Healthy Local Food SMEs in distributing their products. Therefore, Arum Ayu Healthy Local Food SMEs in carrying out promotions using online media mobile applications, where mobile applications are made with a visual approach in order to provide education about mocaf flour and build partnerships to expand business networks through resellers or drop shippers.
Pengendalian Misregister pada Cetakan Kemasan Karton di Mesin Offset
Authors: Galingging Rumbel , Sutriono
Published: September 2023

The offset printing system dominates for the number of prints with medium to small quantities, in the printing process it requires skills and techniques in the printing process from the design process, to the manufacture of offset plates. Many problems that often arise from paper materials and printing techniques, efforts to control the problem of misregister printing on offset sheet-fed machines come from paper that is not angled and from machine factors because the machine is not maintained and because the number of prints is small so the operator ignores the printing process procedure the data is taken from the Pareto analysis tool to the printing process at Indah Sakti Printing on Rawamagun Roast Chicken packaging located in Central Jakarta. From the factors causing problems in the process of printing the â€œPanggang Rawamangunâ€ cardboard packaging on the SM 52 offset sheet-fed machine, the problem is that the gripper pressure is not right so that the print register is difficult to reach and often changes. How to control the prints in the process of printing cardboard packaging by applying the design to be printed in order to minimize the cause of this print misregisters. on the SM 52 offset sheet-fed machine.
Processed Red Ginger (Zingiber Officinale Var Rubrum) into Instant Ginger as a Healthy Drink
Authors: Diana Ruat , Darmawan I Putu Ayub
Published: September 2023

Processed ginger used to be limited as a spice but has now become a health drink. The purpose of this scientific work is to determine the process of making instant ginger with the basic ingredients of red ginger (Zingiber officinale). The method used is qualitative through library research. Data collection techniques through field observations. Literature research and the practice of making instant ginger. This paper provides research information on the health effects of red ginger immunity. The process of processing red ginger becomes instant in a simple way that can be done in the home industry. This instant ginger drink can help increase immunity for Covid-19 survivors and also maintain body health.
Vegetable Salad as a Healthy Food Alternative: Organoleptic Test Method
Authors: Lisanias Haezer , Laukapitang Yunus Daniel Anus , Tessy Charles
Published: September 2023

Vegetables have health benefits. Tomatoes, carrots, lettuce, corn, cucumbers and mayonnaise as flavourings provide a taste that respondents like. The number of respondents is 22 students. The method used is a simple organoleptic test and the product SWOT test. Products are presented and evaluated. The results showed that the vegetable salad was well received in terms of taste, aroma, presentation. Overall, vegetable salad products can be used as an alternative to healthy food.
Postarbejderismen: neo-marxistisk kritik af den aktuelle kapitalisme
Authors: Stephensen Jan Løhmann
Published: September 2023

Selv om det er en nærmest gængs betragtning, at marxismen længe har været fortrængt, har den italienske neomarxistiske skole postarbejderismen i fl ere årtier forsøgt at tage analytisk og praktisk livgreb med kapitalismen i dens postindustrielle form.
Genetic validation of PfFKBP35 as an antimalarial drug target
Authors: Thommen Basil T. , Dziekan Jerzy M. , Achcar Fiona , Tjia Seth , Passecker Armin , Buczak Katarzyna , Gumpp Christin , Schmidt Alexander , Rottmann Matthias , Grüring Christof , Marti Matthias , Bozdech Zbynek , Brancucci Nicolas M. B.
Published: September 2023

Plasmodium falciparum
accounts for the majority of over 600’000 malaria-associated deaths annually. Parasites resistant to nearly all antimalarials have emerged and the need for drugs with alternative modes of action is thus undoubted. The FK506-binding protein
Pf
FKBP35 has gained attention as a promising drug target due to its high affinity to the macrolide compound FK506 (tacrolimus). Whilst there is considerable interest in targeting
Pf
FKBP35 with small molecules, a genetic validation of this factor as a drug target is missing and its function in parasite biology remains elusive. Here, we show that limiting
Pf
FKBP35 levels are lethal to
P. falciparum
and result in a delayed death-like phenotype that is characterized by defective ribosome homeostasis and stalled protein synthesis. Our data furthermore suggest that FK506, unlike the action of this drug in model organisms, exerts its anti-proliferative activity in a
Pf
FKBP35-independent manner and, using cellular thermal shift assays, we identify putative FK506-targets beyond
Pf
FKBP35. In addition to revealing first insights into the function of
Pf
FKBP35, our results show that FKBP-binding drugs can adopt non-canonical modes of action – with major implications for the development of FK506-derived molecules active against
Plasmodium
parasites and other eukaryotic pathogens.
MDverse, shedding light on the dark matter of molecular dynamics simulations
Authors: Tiemann Johanna KS , Szczuka Magdalena , Bouarroudj Lisa , Oussaren Mohamed , Garcia Steven , Howard Rebecca J , Delemotte Lucie , Lindahl Erik , Baaden Marc , Lindorff-Larsen Kresten , Chavent Matthieu , Poulain Pierre
Published: September 2023

The rise of open science and the absence of a global dedicated data repository for molecular dynamics (MD) simulations has led to the accumulation of MD files in generalist data repositories, constituting the dark matter of MD — data that is technically accessible, but neither indexed, curated, or easily searchable. Leveraging an original search strategy, we found and indexed about 250,000 files and 2000 datasets from Zenodo, Figshare and Open Science Framework. With a focus on files produced by the Gromacs MD software, we illustrate the potential offered by the mining of publicly available MD data. We identified systems with specific molecular composition and were able to characterize essential parameters of MD simulation such as temperature and simulation length, and could identify model resolution, such as all-atom and coarse-grain. Based on this analysis, we inferred metadata to propose a search engine prototype to explore the MD data. To continue in this direction, we call on the community to pursue the effort of sharing MD data, and to report and standardize metadata to reuse this valuable matter.
Control of meiotic entry by dual inhibition of a key mitotic transcription factor
Authors: Su Amanda J. , Yendluri Siri C. , Ünal Elçin
Published: September 2023

The mitosis to meiosis transition requires dynamic changes in gene expression, but whether and how the mitotic transcriptional machinery is regulated during this transition is unknown. In budding yeast, SBF and MBF transcription factors initiate the mitotic gene expression program. Here, we report two mechanisms that work together to restrict SBF activity during meiotic entry: repression of the SBF-specific Swi4 subunit through LUTI-based regulation and inhibition of SBF by Whi5, a homolog of the Rb tumor suppressor. We find that untimely SBF activation causes downregulation of early meiotic genes and delays meiotic entry. These defects are largely driven by the SBF-target G1 cyclins, which block the interaction between the central meiotic regulator Ime1 and its cofactor Ume6. Our study provides insight into the role of

SWI4
LUTI

in establishing the meiotic transcriptional program and demonstrates how the LUTI-based regulation is integrated into a larger regulatory network to ensure timely SBF activity.
Iron and copper on Botrytis cinerea: new inputs in the cellular characterization of their inhibitory effect
Authors: Rodríguez-Ramos Fátima , Briones-Labarca Vilbett , Plaza Verónica , Castillo Luis
Published: September 2023

Certain metals play key roles in infection by the gray mold fungus, Botrytis cinerea. Among them, copper and iron are necessary for redox and catalytic activity of enzymes and metalloproteins, but at high concentrations they are toxic. Understanding the mechanism requires more cell characterization studies for developing new, targeted metal-based fungicides to control fungal diseases on food crops. This study aims to characterize the inhibitory effect of copper and iron on B. cinerea by evaluating mycelial growth, sensitivity to cell wall perturbing agents (congo red and calcofluor white), membrane integrity, adhesion, conidial germination, and virulence. Tests of copper over the range of 2 to 8 mM and iron at 2 to 20 mM revealed that the concentration capable of reducing mycelial growth by 50% (IC50) was 2.87 mM and 9.08 mM for copper and iron, respectively. When mixed at equimolar amounts there was a significant inhibitory effect mostly attributable to copper. The effect of Cu50, Fe50, and Cu50–Fe50 was also studied on the mycelial growth of three wild B. cinerea strains, which were more sensitive to metallic inhibitors. A significant inhibition of conidial germination was correlated with adhesion capacity, indicating potential usefulness in controlling disease at early stages of crop growth. Comparisons of the effects of disruptive agents on the cell wall showed that Cu, Fe, and Cu–Fe did not exert their antifungal effect on the cell wall of B. cinerea. However, a relevant effect was observed on plasma membrane integrity. The pathogenicity test confirmed that virulence was correlated with the individual presence of Cu and Fe. Our results represent an important contribution that could be used to formulate and test metal-based fungicides targeted at early prevention or control of B. cinerea.
Identification of anthropogenic debris in the stomach and intestines of giant freshwater prawns from the Trang River in southern Thailand
Authors: Tee-hor Kanyarat , Nitiratsuwan Thongchai , Pradit Siriporn
Published: September 2023

Background

Anthropogenic waste, especially microplastics, is becoming more prevalent in the environment and marine ecosystems, where it has the potential to spread through food chains and be consumed by humans. Southeast Asian countries are home to giant freshwater prawns, a common freshwater species that is eaten around the world. Microplastic pollution in river water, sediment, and commercially significant aquatic species such as fish and mollusks has been observed, yet few studies have been conducted on giant freshwater prawns in the rivers of southern Thailand, where microplastics may contaminate prawns via the food they ingest. The purpose of this research was to investigate the accumulation of anthropogenic material in the organs of river prawns (Macrobrachium rosenbergii).

Methods

Microplastics in the stomachs and intestines of giant freshwater prawns were the focus of this study. Samples were digested with 30 ml of 10% potassium hydroxide (KOH), heated for 5 min at 60 °C, and then digested at room temperature. The quantity, color, and appearance of microplastics were assessed using a stereomicroscope after 12 h. Furthermore, polymers were examined using a Fourier transform infrared spectrophotometer (FTIR). Microplastic counts were compared between sexes. A T-test was used to compare male and female microplastic counts in the stomach and intestine, and the Pearson correlation was used to compare the association between microplastic counts in the stomach and intestine and carapace length (CL), length of abdomen (LA), and body weight (BW) of male and female giant freshwater prawns. The threshold of significance was fixed at p < 0.05.

Results

Based on the study results, a total of 370 pieces of anthropogenic debris were discovered in the stomachs and intestines of both female and male prawns. The average number of microplastics per individual was 4.87 ±  0.72 in female stomachs and 3.03 ± 0.58 in male stomachs, and 1.73 ± 0.36 in female intestines and 2.70 ± 0.57 in male intestines. The majority of microplastics found in females were within the <100 µm range, while males contained microplastics in the range of 100–500 µm. Both male and female prawns contained fibers (72.70%) and fragments (27.30%). Various polymers were identified, including cotton, rayon, and polyvinyl chloride (PVC). The study also explored the relationship between carapace length, length of abdomen, body weight, stomach weight, and the number of microplastics. The findings reveal a significant association between the number of microplastics and stomach weight in male prawns (R = 0.495; p = 0.005). These findings provide alarming evidence of anthropogenic debris ingestion in prawns and raise concerns about the future effects of anthropogenic pollution on giant freshwater prawns.
Assessing the quality of commune-level civil servants in Vietnam
Authors: Trung Ngo Sy , Huong Nguyen Thi Mai , Van Pham Thi
Published: September 2023

In state agencies, civil servants enforce laws and policies according to their areas of expertise to manage social development. The issue of the quality of civil servants is often clearly defined by the laws of the countries, reflected in both their qualifications and their capacity. Many studies also mentioned and analyzed the quality (core competencies) and practical working capacity when assessing the quality of civil servants. In this study, on the basis of inheriting many previous studies and applying the issued legal regulations of Vietnam, the author surveys and evaluates the quality of local civil servants in Vietnam in two areas: Core competencies and practical working capacity of civil servants. The author builds a theoretical framework and directly surveys 270 leaders of communal government agencies in 3 localities representing 3 regions of Vietnam, including: Thai Nguyen province (Northern region), Quang Ngai province (Central region), Tay Ninh province (Southern region). Research results show that local leaders underestimate the practical capacity of civil servants. From the conclusion of this study, the author suggests some contents that need to be researched and adjusted in Vietnam's local government policy on civil servant management.
The Influence of Perceptions of Convenience, Security, Trust, E-Wom, and Attitudes against Students of Uin Malang to Use the Shopee Application
Authors: Fattah Muhammad Fariz Al , Arkaan Dhiya Ulhaq , Kholilah  , Farida Lailatul
Published: September 2023

Current technological developments make activities shift from traditional systems to more modern systems. This change occurs in several aspects, one of which is trade. The existence of digitalization makes activities more effective and efficient, which can be accessed more efficiently using an application. To attract the customer's interest, the company must make a strategy to be trusted. This research examines the influence of several factors on the use of the Shopee application. The sample was taken from Maulana Malik Ibrahim State Islamic University, Malang students. The results of this study revealed that perceptions of convenience, security, trust, and E-WOM did not affect the level of use of the Shopee application by UIN Malang students. Attitude variables influenced the level of use of the shopee application.
Proposed Model for Washback Effect of High-stakes Test in Ghanaian Senior High Schools
Authors: Arthur Francis , Partey Peter Anti
Published: September 2023

This study proposed a model for the washback effect of a high-stakes test in Ghanaian Senior High Schools. The proposed model focused on the micro washback effect of a high-stakes test, as the washback effect is multidimensional. The study reviewed Hughes', Bailey's, and Nguyen's washback effect models of a high-stakes test. The assumption that underpinned the proposed model was that the washback effect of a high-stakes test is inevitable, and it will affect teachers’ classroom instructional practices, implementation of the syllabus, and students’ learning practices. It was concluded that in the classroom context, a high-stakes test could have either a positive or negative effect on classroom instructional practices, implementation of the syllabus, and students’ learning practices.
Study of Non-uniform Seismic Response of Intercity Tunnels with Defective Shields
Authors: Shi Leilei , Xia Donghong
Published: September 2023

Based on the structural viscoelastic boundary theory, considering the geological changes of the soil layer and depth of tunnel crossing, the dynamic time course analysis is carried out for the defective lined tube sheet structure under non-uniform seismic excitation, to obtain the force and deformation law of the whole tunnel structure as well as the defective section. Analyze the dynamic response of shield tunnel structure under non-consistent seismic excitation under the influence of tube sheet misalignment factors, summarize the intrinsic mechanism of the dynamic response of defective tunnel tube lining structure, identify the phenomena affecting lining junction damage, and refine the seismic safety evaluation method of defective lining structure.
BODIES IN DISSENT BETWEEN THE POLITICAL, THE PRIVATE AND THE TECHNOLOGICAL
Authors: Pagnes Andrea
Published: September 2023

The article resumes the author’s lecture Bodies in Dissent. Regarding Live art and performance art, issues such as embodiment and identity are tackled, enriched by excerpts of a recent conversation the author had with Australian performance artist Stelarc about how technology is affecting the human body as a cognitive tool, leading us to reconsider the meaning of human existence.
Lying to My Mom
Authors: Feudtner Chris
Published: September 2023

In this narrative medicine essay, a pediatrician-medical ethicist navigates the decision to honor his 87-year-old mother’s wishes to refrain from cancer treatment and elects not to tell her of a mass in her liver discovered by a CT scan.
Deep Learning for Cardiovascular Imaging
Authors: Wehbe Ramsey M. , Katsaggelos Aggelos K. , Hammond Kristian J. , Hong Ha , Ahmad Faraz S. , Ouyang David , Shah Sanjiv J. , McCarthy Patrick M. , Thomas James D.
Published: September 2023

Importance

Artificial intelligence (AI), driven by advances in deep learning (DL), has the potential to reshape the field of cardiovascular imaging (CVI). While DL for CVI is still in its infancy, research is accelerating to aid in the acquisition, processing, and/or interpretation of CVI across various modalities, with several commercial products already in clinical use. It is imperative that cardiovascular imagers are familiar with DL systems, including a basic understanding of how they work, their relative strengths compared with other automated systems, and possible pitfalls in their implementation. The goal of this article is to review the methodology and application of DL to CVI in a simple, digestible fashion toward demystifying this emerging technology.

Observations

At its core, DL is simply the application of a series of tunable mathematical operations that translate input data into a desired output. Based on artificial neural networks that are inspired by the human nervous system, there are several types of DL architectures suited to different tasks; convolutional neural networks are particularly adept at extracting valuable information from CVI data. We survey some of the notable applications of DL to tasks across the spectrum of CVI modalities. We also discuss challenges in the development and implementation of DL systems, including avoiding overfitting, preventing systematic bias, improving explainability, and fostering a human-machine partnership. Finally, we conclude with a vision of the future of DL for CVI.

Conclusions and Relevance

Deep learning has the potential to meaningfully affect the field of CVI. Rather than a threat, DL could be seen as a partner to cardiovascular imagers in reducing technical burden and improving efficiency and quality of care. High-quality prospective evidence is still needed to demonstrate how the benefits of DL CVI systems may outweigh the risks.
Early Treatment Response in Black Smokers Undergoing Pharmacotherapy for Smoking Cessation
Authors: Leavens Eleanor L. S. , Mayo Matthew S. , Brown Alexandra R. , Cox Lisa Sanderson , Ellerbeck Edward F. , Ahluwalia Jasjit S. , Nollen Nicole L.
Published: September 2023

This secondary analysis of a randomized clinical trial investigates the association of early treatment response with smoking cessation among Black smokers.
Surrogate Adiposity Markers and Mortality
Authors: Khan Irfan , Chong Michael , Le Ann , Mohammadi-Shemirani Pedrum , Morton Robert , Brinza Christina , Kiflen Michel , Narula Sukrit , Akhabir Loubna , Mao Shihong , Morrison Katherine , Pigeyre Marie , Paré Guillaume
Published: September 2023

Importance

Body mass index (BMI) is an easily obtained adiposity surrogate. However, there is variability in body composition and adipose tissue distribution between individuals with the same BMI, and there is controversy regarding the BMI associated with the lowest mortality risk.

Objective

To evaluate which of BMI, fat mass index (FMI), and waist-to-hip (WHR) has the strongest and most consistent association with mortality.

Design, Setting, and Participant

This cohort study used incident deaths from the UK Biobank (UKB; 2006-2022), which includes data from 22 clinical assessment centers across the United Kingdom. UKB British participants of British White ancestry (N = 387 672) were partitioned into a discovery cohort (n = 337 078) and validation cohort (n = 50 594), with the latter consisting of 25 297 deaths and 25 297 controls. The discovery cohort was used to derive genetically determined adiposity measures while the validation cohort was used for analyses. Exposure-outcome associations were analyzed through observational and mendelian randomization (MR) analyses.

Exposures

BMI, FMI, and WHR.

Main Outcomes and Measures

All-cause and cause-specific (cancer, cardiovascular disease [CVD], respiratory disease, or other causes) mortality.

Results

There were 387 672 and 50 594 participants in our observational (mean [SD] age, 56.9 [8.0] years; 177 340 [45.9%] male, 210 332 [54.2%], female), and MR (mean [SD] age, 61.6 [6.2] years; 30 031 [59.3%] male, 20 563 [40.6%], female) analyses, respectively. Associations between measured BMI and FMI with all-cause mortality were J-shaped, whereas the association of WHR with all-cause mortality was linear using the hazard ratio (HR) scale (HR per SD increase of WHR, 1.41 [95% CI, 1.38-1.43]). Genetically determined WHR had a stronger association with all-cause mortality than BMI (odds ratio [OR] per SD increase of WHR, 1.51 [95% CI, 1.32-1.72]; OR per SD increase of BMI, 1.29 [95% CI, 1.20-1.38]; P for heterogeneity = .02). This association was stronger in male than female participants (OR, 1.89 [95% CI, 1.54-2.32]; P for heterogeneity = .01). Unlike BMI or FMI, the genetically determined WHR–all-cause mortality association was consistent irrespective of observed BMI.

Conclusions and Relevance

In this cohort study, WHR had the strongest and most consistent association with mortality irrespective of BMI. Clinical recommendations should consider focusing on adiposity distribution compared with mass.
Structural dynamics at the active site of the cancer‐associated flavoenzyme NQO1 probed by chemical modification with PMSF
Authors: Grieco Alice , Ruiz‐Fresneda Miguel A. , Gómez‐Mulas Atanasio , Pacheco‐García Juan Luis , Quereda‐Moraleda Isabel , Pey Angel L. , Martin‐Garcia Jose M.
Published: September 2023

A large conformational heterogeneity of human NAD(P)H:quinone oxidoreductase 1 (NQO1), a flavoprotein associated with various human diseases, has been observed to occur in the catalytic site of the enzyme. Here, we report the X‐ray structure of NQO1 with phenylmethylsulfonyl fluoride (PMSF) at 1.6 Å resolution. Activity assays confirmed that, despite being covalently bound to the Tyr128 residue at the catalytic site, PMSF did not abolish NQO1 activity. This may indicate that the PMSF molecule does not reduce the high flexibility of Tyr128, thus allowing NADH and DCPIP substrates to bind to the enzyme. Our results show that targeting Tyr128, a key residue in NQO1 function, with small covalently bound molecules could possibly not be a good drug discovery strategy to inhibit this enzyme.
Enhanced reversal of ABCG2‐mediated drug resistance by replacing a phenyl ring in baicalein with a meta‐carborane
Authors: Kuhnert Lydia , Kuhnert Robert , Sárosi Menyhárt B. , Lakoma Cathleen , Scholz Birte K. , Lönnecke Peter , Hey‐Hawkins Evamarie , Honscha Walther
Published: September 2023

Success of chemotherapy is often hampered by multidrug resistance. One mechanism for drug resistance is the elimination of anticancer drugs through drug transporters, such as breast cancer resistance protein (BCRP; also known as ABCG2), and causes a poor 5‐year survival rate of human patients. Co‐treatment of chemotherapeutics and natural compounds, such as baicalein, is used to prevent chemotherapeutic resistance but is limited by rapid metabolism. Boron‐based clusters as meta‐carborane are very promising phenyl mimetics to increase target affinity; we therefore investigated the replacement of a phenyl ring in baicalein by a meta‐carborane to improve its affinity towards the human ABCG2 efflux transporter. Baicalein strongly inhibited the ABCG2‐mediated efflux and caused a fivefold increase in mitoxantrone cytotoxicity. Whereas the baicalein derivative 5,6,7‐trimethoxyflavone inhibited ABCG2 efflux activity in a concentration of 5 μm without reversing mitoxantrone resistance, its carborane analogue 5,6,7‐trimethoxyborcalein significantly enhanced the inhibitory effects in nanomolar ranges (0.1 μm) and caused a stronger increase in mitoxantrone toxicity reaching similar values as Ko143, a potent ABCG2 inhibitor. Overall, in silico docking and in vitro studies demonstrated that the modification of baicalein with meta‐carborane and three methoxy substituents leads to an enhanced reversal of ABCG2‐mediated drug resistance. Thus, this seems to be a promising basis for the development of efficient ABCG2 inhibitors.
Circannual seizure provocation as the day lengthens in the northern and southern hemispheres
Authors: Ng Marcus C. , Zhang Tony , Toutant Darion , Pavlova Milena K. , Bergin Peter , Quigg Mark
Published: September 2023

Circannual status epilepticus (SE) patterns in communities near Earth's poles best test the hypothesis that SE susceptibility varies with light exposure because these communities are routinely subject to large changes in annual light exposure, which may result in changes to daily sleep time. We compared northern hemispheric circannual SE occurrence in Kivalliq, Canada (latitude‐62.8° N) to southern hemispheric Auckland, New Zealand (latitude‐36.9° S). Instead of peaking at a similar calendar time, SE peaked at a similar solar time during the increasing daylight phase after each region's respective winter solstice. This demonstrates that cumulative effects of increasing light exposure can mediate SE susceptibility.
Flexible performance‐based adaptive fault‐tolerant attitude tracking control for input‐constrained satellite
Authors: Li Baomin , Yong Kenan , Chen Mou , Shao Shuyi
Published: September 2023

Under the actuator saturation and fault, the satellite attitude often violates the prescribed performance function, leading to the satellite attitude's instability. Therefore, the adaptive attitude tracking control problem for the satellite simultaneously considering the finite time‐based prescribed performance, the actuator saturation and the actuator fault is studied in this article. A modification performance function‐based control scheme is designed, which can avoid violating the designed modified performance functions when the actuator saturation occurs due to the actuator fault. A novel fault tolerant auxiliary system is developed, which is used to generate modification signals for adjusting the prescribed performance function. Consequently, the boundedness of all the closed‐loop signal under the designed control scheme is proved via Lyapunov function method. Finally, the feasibility of the designed satellite attitude control scheme is verified by a simulation example.
A Chemoimmunotherapy Nanogel Enables Efficient Delivery of Interleukin‐2 and Induction of Immunogenic Cell Death for Effective Cancer Therapy
Authors: Mu Hsuan‐Yu , Ta Yen‐Nhi Ngoc , Tham Max Jing Rui , Hsu Fu‐Fei , Lin Yu‐Chieh , Huang Hsi‐Chien , Sung Yun‐Chieh , Huang Chih‐I , Wu Ching‐Ling , Chang Chao‐Hung , Yang Sheng , Lee Tsung‐Ying , Wan Dehui , Wang Jane , Duda Dan G. , Boucher Yves , Huang Jen‐Huang , Ang Wee Han , Chen Yunching
Published: September 2023

Interleukin‐2 (IL‐2) is one of the first FDA‐approved immunotherapeutics, but its use is limited by toxicity and low efficacy. In addition, all immunotherapies are limited by the immunosuppressive and desmoplastic microenvironment of “immunologically cold” tumors, such as pancreatic ductal adenocarcinoma (PDAC) or hepatocellular carcinoma (HCC) with advanced liver fibrosis. Here, a new chemoimmunotherapy nanogel (IL2‐Pt@Nanogel) for dual delivery of IL‐2 and the type II immunogenic cell death inducer Pt‐NHC that reduces the immunosuppressive phenotype of tumor‐associated macrophages and diminishes regulatory T cell infiltration by inducing the production of type I interferon (IFN) by cancer cells is reported. Combining the angiotensin II receptor blocker losartan with IL2‐Pt@Nanogel treatment reduces desmoplasia and reprogrammes the microenvironment of PDAC and HCC toward an immunostimulatory one. These effects result in potent anti‐tumor efficacy in models of primary and metastatic PDAC and HCC with underlying liver fibrosis. This study presents a strategy for IL‐2‐based chemoimmunotherapy with the potential for clinical translation to treat solid tumors.
Tunable and Robust Mid‐Infrared Saturable Absorber Employing Tungsten Doping Cadmium Oxide
Authors: Wang Mengxia , Wang Ying , Wu Yi , Ma Hao , Jiang Hang , Zhao Yuanan , Peng Yujie , Li Wenkai , Leng Yuxin , Yu Kin Man , Shao Jianda
Published: September 2023

Mid‐infrared (MIR) pulsed lasers operating at 2–5 µm have important applications in communication, sensing, and medicine. However, the lack of robust MIR saturable absorbers (SAs) remains a major obstacle. Here, a semiconductor material cadmium oxide (CdO) film with high laser‐induced damage threshold (800 nm, 134 mJ cm−2) and broadband saturable absorption (2.0–3.9 µm) is investigated. The effective tuning of the nonlinear optical response of CdO is demonstrated by adjusting the carrier concentration via a tungsten (W)‐doping scheme. The saturable absorption is improved and carrier relaxation process is accelerated after increasing the W‐dopant level. Based on these findings, the robust CdO‐SAs with customizable parameters are realized and Q‐switched lasers with decreasing pulse width from 372 to 254.3 ns are obtained at 2 µm. The design flexibility provided by CdO opens up a large parameter space that enables the continuous improvement of compact and high‐performance MIR ultrafast lasers.
Interplay between Collective and Localized Effects of Point Defects on Photoelectrochemical Performance of TiO2 Photoanodes for Oxygen Evolution
Authors: Yang Mengya , Cui Junyi , Daboczi Matyas , Law Robert V. , Luke Joel , Kim Ji‐Seon , Hankin Anna , Eslava Salvador
Published: September 2023

Among the various photoanode materials investigated for photoelectrochemical water splitting cells, TiO2 stands out due to its abundance, stability, and favorable valence band edge for water oxidation. In this study, the importance of introducing and combining oxygen and titanium vacancy point defects in anatase TiO2 photoanodes to improve their performance is unveiled, achieving a photocurrent density of 0.73 (±0.015) mA cm−2 at +1.23 VRHE under 100 mW cm−2 of simulated sunlight or 26.4 mA cm−2 at +1.23 VRHE under 100 mW cm−2 of 365 nm light. The characterization by X‐ray photoelectron spectroscopy, surface photovoltage, and electron paramagnetic resonance demonstrates that these oxygen and titanium vacancies can have both collective and localized positive effects on the material, leading to a narrowing of the bandgap, an increase in donor density, and an increase in hydroxyl groups on the surface of TiO2. These result in enhanced light absorption, conductivity, and photovoltage, as well as a more negative flat‐band potential and increase in hole flux to the semiconductor–electrolyte interface. These findings provide valuable insights into the role of point defects in modulating the properties of TiO2 and have important implications for the development of high‐performance TiO2‐based devices.
Variability of Radionuclide Sorption Efficiency on Muscovite Cleavage Planes
Authors: Schabernack Jonas , Oliveira Augusto Faria , Heine Thomas , Fischer Cornelius
Published: September 2023

In deep geological repositories for nuclear waste, the surrounding rock formation serves as an important barrier against radionuclide migration. Multiple potential host rocks contain phyllosilicates, which have shown high efficiency in radionuclide sorption. Recent experimental studies report a heterogeneous distribution of adsorbed radionuclides on nanotopographic mineral surfaces. In this study, the energetic differences of surface sorption sites available at nanotopographic structures such as steps, pits, and terraces are investigated. Eleven important surface sites are selected and the energies of ad‐ and desorption reactions are obtained from density functional theory calculations. The adsorption energies are then used for the parameterization of a kinetic Monte Carlo model simulating the distribution of adsorbed europium on a typical nanotopographic muscovite surface. On muscovite, silicon step sites are favorable for europium sorption and lead to an increased adsorption in regions with high step concentrations. Under identical chemical conditions, sorption on typical nanotopographic surfaces is increased by a factor of three compared to atomically flat surfaces. Desorption occurs preferentially at terrace sites, leading to an overall 2.5 times increased retention at nanotopographic structures. This study provides a mechanistic explanation for heterogeneous sorption on nanotopographic mineral surfaces due to the availability of energetically favorable sorption sites.
Janus Device Based on Liquid Crystal Regulation with a Large Incidence Angle: Analogous Quantum Optical Effect and Absorption
Authors: Liao Si‐yuan , Sui Jun‐yang , Chen Qi , Zhang Hai‐Feng , Li Bing‐Xiang
Published: September 2023

In this paper, a Janus metastructure device (JMD) is proposed. The JMD design introduces asymmetric structures, which leads to the generation of analogous quantum optical effects when light is incident at large angles. Specifically, forward electromagnetic‐induced transparency (EIT) and backward narrowband absorption (NA) are achieved when light is incident along different directions, displaying Janus characteristics in the forward and backward directions. Additionally, the operating frequency of JMD can be controlled through the use of liquid crystal. Such features hold promising potential for various applications in photonic and optoelectronic fields. When the axial direction of the liquid crystal is oriented along the x‐direction, the JMD achieves a transparent window over 90% within 0.46–0.51 THz at forward incidence, and an absorption peak of 84.1% appears at 0.331 THz at backward incidence. When the axial direction is oriented along the y‐direction, the JMD achieves EIT in the range of 0.51–0.575 THz at forward incidence, and a backward absorption peak of 93.3% occurs at 0.305 THz. In addition, the performance changes at different polarization and incidence angles are presented. The mechanism of absorption generation, the method of suppressing excess absorption, and the parametric inversion of the electromagnetic characteristics of JMD are also discussed.
Ab Initio Thermodynamics Calculation of Beta Decay Rates
Authors: Parker Michael C. , Jeynes Christopher
Published: September 2023

Beta‐decay half‐lives for the free neutron, for 6He and 8He, and for 8Li are calculated ab initio from geometrical thermodynamics arguments, independently of any quantum mechanics. Half‐lives for the decay of 8Be to two alphas and for the disintegration of the tetraneutron are also calculated. The calculated values are close to those experimentally observed.
Color‐Tunable Dual‐Mode Organic Afterglow for White‐Light Emission and Information Encryption Based on Carbazole Doping
Authors: Zhang Xianhe , Chong Kok Chan , Xie Zongliang , Liu Bin
Published: September 2023

Dual‐mode emission materials, combining phosphorescence and delayed fluorescence, offer promising opportunities for white‐light afterglow. However, the delayed fluorescence lifetime is usually significantly shorter than that of phosphorescence, limiting the duration of white‐light emission. In this study, a carbazole‐based host–guest system that can be activated by both ultraviolet (UV) and visible light is reported to achieve balanced phosphorescence and delayed fluorescence, resulting in a long‐lived white‐light afterglow. Our study demonstrated the critical role of a charge transfer state in the afterglow mechanism, where the charge separation and recombination process directly determined the lifetime of afterglow. Simultaneously, an efficient reversed intersystem crossing process was obtained between the singlet and triplet charge transfer states, which facilitating the delayed fluorescence properties of host–guest system. As a result, delayed fluorescence lifetime was successfully prolonged to approach that of phosphorescence. This work presents a delayed fluorescence lifetime improvement strategy via doping method to realize durable white‐light afterglow.
Sulfonium Salt Reagents for the Introduction of Deuterated Alkyl Groups in Drug Discovery
Authors: Ban Kazuho , Imai Keisuke , Oyama Shuki , Tokunaga Jin , Ikeda Yui , Uchiyama Hiromasa , Kadota Kazunori , Tozuka Yuichi , Akai Shuji , Sawama Yoshinari
Published: September 2023

The pharmacokinetics of pharmaceutical drugs can be improved by replacing C−H bonds with the more stable C−D bonds at the α‐position to heteroatoms, which is a typical metabolic site for cytochrome P450 enzymes. However, the application of deuterated synthons is limited. Herein, we established a novel concept for preparing deuterated reagents for the successful synthesis of complex drug skeletons with deuterium atoms at the α‐position to heteroatoms. (dn‐Alkyl)diphenylsulfonium salts prepared from the corresponding nondeuterated forms using inexpensive and abundant D2O as the deuterium source with a base, were used as electrophilic alkylating reagents. Additionally, these deuterated sulfonium salts were efficiently transformed into dn‐alkyl halides and a dn‐alkyl azide as coupling reagents and a dn‐alkyl amine as a nucleophile. Furthermore, liver microsomal metabolism studies revealed deuterium kinetic isotope effects (KIE) in 7‐(d2‐ethoxy)flavone. The present concept for the synthesis of deuterated reagents and the first demonstration of a KIE in a d2‐ethoxy group will contribute to drug discovery research based on deuterium chemistry.
Nanosheet‐Assembled Zirconium‐Porphyrin Frameworks Enabling Surface‐Confined, Initiator‐Free Photosynthesis of Ultrahigh Molecular Weight Polymers
Authors: Gao Qiang , Wang Wei , Du Jingbo , Liu Zeyu , Geng Yiyun , Ding Xiaojun , Chen Yifei , Chen Jing , Ye Gang
Published: September 2023

Metal–organic frameworks with well‐organized low‐dimensional architectures provide significant thermodynamic and/or kinetic benefits for diverse applications. We present here the controlled synthesis of a novel class of hierarchical zirconium‐porphyrin frameworks (ZrPHPs) with nanosheet‐assembled hexagonal prism morphology. The crystal growth behaviors and structural evolution of ZrPHPs in an additive‐modulated solvothermal synthesis are examined, showing an “assembly‐hydrolysis‐reassembly” mechanism towards the formation of 2D nanosheets with ordered arrangement. Because of the highly‐accessible active sites harvesting broadband photons, ZrPHPs serve as adaptable photocatalysts to regulate macromolecular synthesis under full‐range visible light and natural sunlight. An initiator‐free, oxygen‐tolerant photopolymerization system is established, following a distinctive mechanism involving direct photo‐induced electron transfer to dormant species and hole‐mediated reversible deactivation. Specifically, ZrPHPs provide a surface‐confined effect towards the propagating chains which inhibits their recombination termination, enabling the highly‐efficient synthesis of ultrahigh molecular weight polymers (Mn >1,500,000) with relatively low dispersity (Đ≈1.5).
Highly Uniform DNA Monolayers Generated by Freezing‐Directed Assembly on Gold Surfaces Enable Robust Electrochemical Sensing in Whole Blood
Authors: Li Zhenglian , Lv Yanguan , Duan Xiaoman , Liu Biwu , Zhao Yongxi
Published: September 2023

Assembling DNA on solid surfaces is fundamental to surface‐based DNA technology. However, precise control over DNA conformation and organization at solid–liquid interfaces remains a challenge, resulting in limited stability and sensitivity in biosensing applications. We herein communicate a simple and robust method for creating highly uniform DNA monolayers on gold surfaces by a freeze‐thawing process. Using Raman spectroscopy, fluorescent imaging, and square wave voltammetry, we demonstrate that thiolated DNA is concentrated and immobilized on gold surfaces with an upright conformation. Moreover, our results reveal that the freezing‐induced DNA surfaces are more uniform, leading to improved DNA stability and target recognition. Lastly, we demonstrate the successful detection of a model drug in undiluted whole blood while mitigating the effects of biofouling. Our work not only provides a simple approach to tailor the DNA‐gold surface for biosensors but also sheds light on the unique behavior of DNA oligonucleotides upon freezing on the liquid‐solid interface.
Synthetic Membraneless Droplets for Synaptic‐Like Clustering of Lipid Vesicles
Authors: Li Qingchuan , Song Qingchun , Guo Wei , Cao Yang , Cui Xinyu , Chen Dairong , Shum Ho Cheung
Published: September 2023

In eukaryotic cells, the membraneless organelles (MLOs) formed via liquid‐liquid phase separation (LLPS) are found to interact intimately with membranous organelles (MOs). One major mode is the clustering of MOs by MLOs, such as the formation of clusters of synaptic vesicles at nerve terminals mediated by the synapsin‐rich MLOs. Aqueous droplets, including complex coacervates and aqueous two‐phase systems, have been plausible MLO‐mimics to emulate or elucidate biological processes. However, neither of them can cluster lipid vesicles (LVs) like MLOs. In this work, we develop a synthetic droplet assembled from a combination of two different interactions underlying the formation of these two droplets, namely, associative and segregative interactions, which we call segregative‐associative (SA) droplets. The SA droplets cluster and disperse LVs recapitulating the key functional features of synapsin condensates, which can be attributed to the weak electrostatic interaction environment provided by SA droplets. This work suggests LLPS with combined segregative and associative interactions as a possible route for synaptic clustering of lipid vesicles and highlights SA droplets as plausible MLO‐mimics and models for studying and mimicking related cellular dynamics.
Catalytic pyrolysis of lignite with clay catalyst activated with spent pickling liquor
Authors: Kar Yakup , Mert Bayram Ali
Published: September 2023

Spent pickling liquor (SPL) is an acidic waste with rich iron content from the stainless steel production industry. Reusability of SPL as a catalytic activity promoter in bentonite clay is crucial for the catalytic pyrolysis of various materials like biomass, coal, and waste plastics. For this aim, the bentonite catalyst activated with the SPL nomenclatured as SPL‐treated bentonite (SPLAB) catalyst was employed in the catalytic pyrolysis of lignite for an oil product with high yield and quality. The SPL‐treated bentonite catalytic pyrolysis oil (SPLABO) for the conditions of the final temperature of 600°C, heating rate of 10°C/min, and catalyst ratio of 15 wt% had a yield of 26.35 ± 1.14 wt% and good fuel properties in view of the higher heating value of 35.23 MJ/kg and density of 1076.4 kg/m3 at 20°C. Moreover, it has a rich chemical content by means of monocyclic aromatics and shorter chain alkanes compared with that of the thermal activated bentonite oil (TABO). Based on the chemical structure analysis results of the SPLABO and TABO comparatively, it was concluded that the SPL agent used as a catalytic activity promoter led to a significant increase in the catalytic activity of bentonite catalyst.