bluuebunny/crossref_metadata_2025 huggingface dataset:
Hybrid Controlled Multi-Input DC/DC Converter for Electric Vehicle Application
Authors: Bharathidasan Mohan , Indragandhi Vairavasundaram , Aljafari Belqasem
Published: April 2023

The use of energy sources for electric vehicle (EV) applications relies heavily on the power electronic interlinking and its successful control mechanism. A hybrid adaptive neuro-fuzzy inference system (ANFIS) proportional-integral (PI) based control strategy for a multi-input DC-DC converter is investigated in-depth for this purpose. At steady state, the proposed hybrid ANFIS PI controller uses the standard PI controller, and during the transient state, the ANFIS PI control strategy is used. Furthermore, the proposed control scheme aids in the tracing of a predetermined speed pattern in order to achieve total EV. A detailed simulation analysis of the proposed control strategy is carried out and its performace was compared with traditional controllers. The result indicated that the designed control strategy is reliable since it offers bidirectional power management, high gain with quick reaction, and low steady-state error. It enables rapid tracking and achieves improved dynamic response through increased flexibility and energy efficiency. The proposed scheme reduces component stress, as demonstrated by a reliability assessment using the MIL-HDBK-217F military handbook. At nominal power, the converter achieves 96.954% efficiency. An 80 W converter prototype was created and tested in the laboratory to monitor the real-time system’s response time.
Supplementary Data from Driver Mutations Dictate the Immunologic Landscape and Response to Checkpoint Immunotherapy of Glioblastoma
Authors: Yeo Alan T. , Shah Rushil , Aliazis Konstantinos , Pal Rinku , Xu Tuoye , Zhang Piyan , Rawal Shruti , Rose Christopher M. , Varn Frederick S. , Appleman Vicky A. , Yoon Joon , Varma Hemant , Gygi Steven P. , Verhaak Roel G.W. , Boussiotis Vassiliki A. , Charest Al
Published: April 2023

supplementary figures & legends
Supplementary Data Table 2 from Driver Mutations Dictate the Immunologic Landscape and Response to Checkpoint Immunotherapy of Glioblastoma
Authors: Yeo Alan T. , Shah Rushil , Aliazis Konstantinos , Pal Rinku , Xu Tuoye , Zhang Piyan , Rawal Shruti , Rose Christopher M. , Varn Frederick S. , Appleman Vicky A. , Yoon Joon , Varma Hemant , Gygi Steven P. , Verhaak Roel G.W. , Boussiotis Vassiliki A. , Charest Al
Published: April 2023

Supplementary table 2
Data from Discovery of Podofilox as a Potent cGAMP–STING Signaling Enhancer with Antitumor Activity
Authors: Han Jing , Hu Shuiqing , Hu Yawei , Xu Yifang , Hou Yanfei , Yang Yinlong , Su Huili , Zhang Zhengyin , Liu Peng , Sun Xuxu , Zhang Conggang
Published: April 2023

Abstract
Cyclic GMP–AMP (cGAMP) is a second messenger that activates the stimulator of interferon genes (STING) innate immune pathway to induce the expression of type I IFNs and other cytokines. Pharmacologic activation of STING is considered a potent therapeutic strategy in cancer. In this study, we used a cell-based phenotypic screen and identified podophyllotoxin (podofilox), a microtubule destabilizer, as a robust enhancer of the cGAMP–STING signaling pathway. We found that podofilox enhanced the cGAMP-mediated immune response by increasing STING-containing membrane puncta and the extent of STING oligomerization. Furthermore, podofilox changed the trafficking pattern of STING and delayed trafficking-mediated STING degradation. Importantly, the combination of cGAMP and podofilox had profound antitumor effects on mice by activating the immune response through host STING signaling. Together, these data provide insights into the regulation of cGAMP–STING pathway activation and demonstrate what we believe to be a novel approach for modulating this pathway and thereby promoting antitumor immunity.
Table S6 from Genome-wide CRISPR screen reveals RAB10 as a synthetic lethal gene in colorectal and pancreatic cancers carrying SMAD4 loss.
Authors: Erasimus Helene , Kolnik Vanessa , Lacroix Frederic , Sidhu Sukhvinder S , D'Agostino Stephane , Lemaitre Olivier , Rohaut Alexandre , Sanchez Isabelle , Thill Gilbert , Didier Michel , Debussche Laurent , Marcireau Christophe
Published: April 2023

94 Putative synthetic lethal genes identified in the screen
Table S2 from Genome-wide CRISPR screen reveals RAB10 as a synthetic lethal gene in colorectal and pancreatic cancers carrying SMAD4 loss.
Authors: Erasimus Helene , Kolnik Vanessa , Lacroix Frederic , Sidhu Sukhvinder S , D'Agostino Stephane , Lemaitre Olivier , Rohaut Alexandre , Sanchez Isabelle , Thill Gilbert , Didier Michel , Debussche Laurent , Marcireau Christophe
Published: April 2023

QCsummary
Table S1 from Genome-wide CRISPR screen reveals RAB10 as a synthetic lethal gene in colorectal and pancreatic cancers carrying SMAD4 loss.
Authors: Erasimus Helene , Kolnik Vanessa , Lacroix Frederic , Sidhu Sukhvinder S , D'Agostino Stephane , Lemaitre Olivier , Rohaut Alexandre , Sanchez Isabelle , Thill Gilbert , Didier Michel , Debussche Laurent , Marcireau Christophe
Published: April 2023

library preparation primers
Supplementary Figure 3 from Genome-wide CRISPR screen reveals RAB10 as a synthetic lethal gene in colorectal and pancreatic cancers carrying SMAD4 loss.
Authors: Erasimus Helene , Kolnik Vanessa , Lacroix Frederic , Sidhu Sukhvinder S , D'Agostino Stephane , Lemaitre Olivier , Rohaut Alexandre , Sanchez Isabelle , Thill Gilbert , Didier Michel , Debussche Laurent , Marcireau Christophe
Published: April 2023

Behavior of sgRNAs targeting essential and nonessential genes in the screen samples.
Supplementary Figure 2 from Genome-wide CRISPR screen reveals RAB10 as a synthetic lethal gene in colorectal and pancreatic cancers carrying SMAD4 loss.
Authors: Erasimus Helene , Kolnik Vanessa , Lacroix Frederic , Sidhu Sukhvinder S , D'Agostino Stephane , Lemaitre Olivier , Rohaut Alexandre , Sanchez Isabelle , Thill Gilbert , Didier Michel , Debussche Laurent , Marcireau Christophe
Published: April 2023

S2. Quality check of the CRISPR screen samples.
Nasogastric Tube Syndrome: A Severe Complication of Nasointestinal Ileus Tube
Authors: Taira Kenkichiro , Koyama Satoshi , Morisaki Tsuyoshi , Fukuhara Takahiro , Donishi Ryouhei , Fujiwara Kazunori
Published: April 2023

Nasogastric tube syndrome (NGTS) induced by a nasointestinal ileus tube is an uncommon but potentially life-threatening complication. NGTS often becomes serious and progresses to acute upper airway obstruction caused by bilateral vocal cord paralysis or laryngeal infection. Early detection and proper treatment of NGTS are necessary. We describe the case of a 78-year-old patient with this syndrome induced by a nasointestinal ileus tube. At administration, ileus was suspected based on physical examination and thoracoabdominal X-ray findings. A nasointestinal ileus tube was placed through the left nasal cavity. Three days after tube placement, hoarseness and wheezing were found during nutrition support team rounds. Upper airway obstruction was suspected and evaluated immediately with flexible laryngoscopy by an otolaryngologist. The nasointestinal ileus tube was removed. The symptoms decreased with prompt proper management. Immediate removal of the tube and early recognition of symptoms are the first steps in the treatment for this syndrome, in addition to the initiation of steroid, proton pump inhibitor, and antibiotic therapy. The cause of NGTS is thought to be continuous pressure on the hypopharynx and cervical esophagus. NGTS should be considered in patients with either nasogastric or nasointestinal ileus tubes. Early diagnosis and proper management of NGTS are important.
Defining Current Patterns of Blood Product Use during Intensive Induction Chemotherapy in Newly Diagnosed Acute Myeloid Leukemia Patients
Authors: Miller Liron , Freed-Freundlich Mor , Shimoni Avichai , Hellou Tamer , Avigdor Abraham , Misgav Mudi , Canaani Jonathan
Published: April 2023

Introduction: Blood product transfusion retains a critical role in the supportive care of patients with acute myeloid leukemia (AML). Whereas previous studies have shown increased transfusion dependency to portend inferior outcome, predictive factors of an increased transfusion burden and the prognostic impact of transfusion support have not been assessed recently. Methods/Patients: We performed a retrospective analysis on a recent cohort of patients given intensive induction chemotherapy in 2014–2022. Results: The analysis comprised 180 patients with a median age of 57 years with 80% designated as de novo AML. Fifty-four patients (31%) were FLT3-ITD mutated, and 73 patients (42%) harbored NPM1. Favorable risk and intermediate risk ELN 2017 patients accounted for 43% and 34% of patients, respectively. The median number of red blood cell (RBC) and platelet units given during induction were 9 and 7 units, respectively. Seventeen patients (9%) received cryoprecipitate, and fresh frozen plasma (FFP) was given to 12 patients (7%). Lower initial hemoglobin and platelet levels were predictive of increased use of RBC (p < 0.0001) and platelet transfusions (p < 0.0001). FFP was significantly associated with induction related mortality (42% vs. 5%; p < 0.0001) and with FLT3-ITD (72% vs. 28%; p = 0.004). Blood group AB experienced improved mean overall survival compared to blood group O patients (4.1 years vs. 2.8 years; p = 0.025). In multivariate analysis, increased number of FFP (hazard ratio [HR], 4.23; 95% confidence interval [CI], 2.1–8.6; p < 0.001) and RBC units (HR, 1.8; 95% CI, 1.2–2.8; p = 0.008) given was associated with inferior survival. Conclusion: Transfusion needs during induction crucially impact the clinical trajectory of AML patients.
Clinical Guidelines for Diagnosis and Management of Peutz-Jeghers Syndrome in Children and Adults
Authors: Yamamoto Hironori , Sakamoto Hirotsugu , Kumagai Hideki , Abe Takashi , Ishiguro Shingo , Uchida Keiichi , Kawasaki Yuko , Saida Yoshihisa , Sano Yasushi , Takeuchi Yoji , Tajika Masahiro , Nakajima Takeshi , Banno Kouji , Funasaka Yoko , Hori Shinichiro , Yamaguchi Tatsuro , Yoshida Teruhiko , Ishikawa Hideki , Iwama Takeo , Okazaki Yasushi , Saito Yutaka , Matsuura Nariaki , Mutoh Michihiro , Tomita Naohiro , Akiyama Takashi , Yamamoto Toshiki , Ishida Hideyuki , Nakayama Yoshiko
Published: April 2023

Background: Peutz-Jeghers syndrome (PJS) is a rare disease characterized by the presence of hamartomatous polyposis throughout the gastrointestinal tract, except for the esophagus, along with characteristic mucocutaneous pigmentation. It is caused by germline pathogenic variants of the STK11 gene, which exhibit an autosomal dominant mode of inheritance. Some patients with PJS develop gastrointestinal lesions in childhood and require continuous medical care until adulthood and sometimes have serious complications that significantly reduce their quality of life. Hamartomatous polyps in the small bowel may cause bleeding, intestinal obstruction, and intussusception. Novel diagnostic and therapeutic endoscopic procedures such as small-bowel capsule endoscopy and balloon-assisted enteroscopy have been developed in recent years. Summary: Under these circumstances, there is growing concern about the management of PJS in Japan, and there are no practice guidelines available. To address this situation, the guideline committee was organized by the Research Group on Rare and Intractable Diseases granted by the Ministry of Health, Labour and Welfare with specialists from multiple academic societies. The present clinical guidelines explain the principles in the diagnosis and management of PJS together with four clinical questions and corresponding recommendations based on a careful review of the evidence and involved incorporating the concept of the Grading of Recommendations Assessment, Development and Evaluation system. Key Messages: Herein, we present the English version of the clinical practice guidelines of PJS to promote seamless implementation of accurate diagnosis and appropriate management of pediatric, adolescent, and adult patients with PJS.
The Skeletal Muscle Transcriptome Profile of Elderly Men with Metabolic Syndrome Based on Weighted Gene Co-Expression Network Analysis
Authors: Ge Xing , Wang Qingqing , Yao Tingting , Xie Jiafei , Zhang Chaoran , Xu Li-Chun
Published: April 2023

Introduction: This study aimed to understand the transcriptome characteristics of the skeletal muscle of elderly (EL) men with metabolic syndrome (MS) and to find the hub genes and insight into the molecular mechanisms of skeletal muscle in the occurrence and development of MS. Methods: In this study, the limma package of R software was used to analyze the differentially expressed genes in the skeletal muscle of healthy young (YO) adult men, healthy EL men, and EL men diagnosed with MS (SX) for at least 10 years. Bioinformatics methods, such as GO enrichment analysis, KEGG enrichment analysis, and gene interaction network analysis, were used to explore the biological functions of differentially expressed genes, and weighted gene coexpression network analysis (WGCNA) was used to cluster differentially expressed genes into modules. Results: Among the YO group, EL group, and SX group, 65 co-differentially expressed genes were found maybe regulated by age factor and MS factor. Those co-differentially expressed genes were enriched into 25 biological process terms and 3 KEGG pathways. Based on the WGCNA results, a total of five modules were identified. Fifteen hub genes may play an essential role in regulating the function of skeletal muscle of EL men with MS. Conclusions: 65 differentially expressed genes and 5 modules may regulate the function of skeletal muscle of EL men with MS, among which fifteen hub genes may play an essential role in the occurrence and development of MS.
Ethos e Self em três orações em defesa das mulheres no renascimento
Authors: Adami Ana Leticia
Published: April 2023

É largamente reconhecido no interior dos estudos das Humanidades, em especial no campo da Filosofia, a lacuna deixada acerca da compreensão do papel das mulheres e da sua produção intelectual no pensamento filosófico. Tal preocupação deve-se, em grande parte, à produção divulgada por outras áreas de estudos, como as de gênero e da teoria feminista. No caso do campo filosófico, trata-se de reconhecer que a história da filosofia nunca foi feita só por homens, ainda mais quando se tratou da defesa da liberdade das mulheres e da sua luta por inserção e reconhecimento intelectuais. Neste sentido, este trabalho visa analisar comparativamente três discursos em defesa da liberdade das mulheres, escritos por duas jovens autoras e um autor, em momentos distintos. Em primeiro lugar, temos o discurso de um jovem professor de retórica, Lorenzo Valla, contido no seu diálogo Do Prazer, de 1431; em segundo, temos o diálogo Il Merito delle Donne, da escritora veneziana Moderata Fonte, publicado postumamente em 1600; e, por fim, o texto da Tirannia Paterna, de outra escritora veneziana, a filósofa Arcangela Tarabotti, publicado postumamente em 1654. Em todos os três casos, tratam-se de discursos endereçados aos homens, em repúdio por seus crimes cometidos contra a liberdade das mulheres e o livre-arbítrio em geral. Desse modo, tomando como eixo de análise a semelhança temática entre tais textos, será de nosso interesse observar a relação entre o ethos dos falantes com o self dos autores nessas três orações distintas, levando em consideração ainda o gênero de discurso, a audiência, os efeitos retóricos e o contexto em que as obras se inscreveram.
Intensificação laboral e gênero profissional de professoras da educação infantil
Authors: Pinheiro Francisco Pablo Huascar Aragão , Rodrigues Cristina Silmara Duarte , Camelo Elysne , Sousa Francisca Valéria de , Melo Quitéria Alves , Marques Natália Santos , Melo Pamella Beserra de
Published: April 2023

As reformas neoliberais levaram à intensificação do trabalho, dado a exigência de maiores e melhores resultados em contextos laborais com condições insuficientes para realizá-lo. O presente artigo visa compreender, a partir do referencial teórico da Clínica da Atividade, a relação entre intensificação do trabalho docente e gênero profissional. Trata-se de estudo de caso derivado de uma intervenção com seis professoras da Educação Infantil, que utilizou o método de instrução ao sósia. Os registros de áudio produzidos ao longo das instruções ao sósia foram transcritos e submetidos à análise construtivo-interpretativa. O número de alunos por sala, fator inerente à organização do trabalho, era promotor da intensificação, uma vez que exigia mais dos profissionais sem a contrapartida necessária das condições de trabalho. Nesse cenário ocorreu a construção coletiva do que era chamado de “domínio de sala”, norma de proceder não oficializada, relativa às habilidades necessárias à atuação docente para lidar com a intensificação laboral. Houve, assim, a construção de uma cultura profissional que orientava a ação das docentes, de modo a viabilizar a atividade e preservar o poder de agir.
Rbpj Deficiency Disrupts Vascular Remodeling via Abnormal Apelin and Cdc42 (Cell Division Cycle 42) Activity in Brain Arteriovenous Malformation
Authors: Adhicary Subhodip , Fanelli Kayleigh , Nakisli Sera , Ward Brittney , Pearce Isaac , Nielsen Corinne M.
Published: April 2023

Background:

Brain arteriovenous malformations (bAVM) are characterized by enlarged blood vessels, which direct blood through arteriovenous shunts, bypassing the artery-capillary-vein network and disrupting blood flow. Clinically, bAVM treatments are invasive and not routinely applicable. There is critical need to understand mechanisms of bAVM pathologies and develop pharmacological therapies.

Methods:

We used an in vivo mouse model of Rbpj-mediated bAVM, which develops pathologies in the early postnatal period and an siRNA in vitro system to knockdown RBPJ in human brain microvascular endothelial cells (ECs). To understand molecular events regulated by endothelial Rbpj, we conducted RNA-Seq and chromatin immunoprecipitation-Seq analyses from isolated brain ECs.

Results:

Rbpj-deficient (mutant) brain ECs acquired abnormally rounded shape (with no change to cell area), altered basement membrane dynamics, and increased endothelial cell density along arteriovenous shunts, compared to controls, suggesting impaired remodeling of neonatal brain vasculature. Consistent with impaired endothelial cell dynamics, we found increased Cdc42 (cell division cycle 42) activity in isolated mutant ECs, suggesting that Rbpj regulates small GTPase (guanosine triphosphate hydrolase)-mediated cellular functions in brain ECs. siRNA-treated,
RBPJ
-deficient human brain ECs displayed increased Cdc42 activity, disrupted cell polarity and focal adhesion properties, and impaired migration in vitro. RNA-Seq analysis from isolated brain ECs identified differentially expressed genes in mutants, including
Apelin
, which encodes a ligand for G protein-coupled receptor signaling known to influence small GTPase activity. Chromatin immunoprecipitation-Seq analysis revealed chromatin loci occupied by Rbpj in brain ECs that corresponded to G-protein and Apelin signaling molecules. In vivo administration of a competitive peptide antagonist against the Apelin receptor (Aplnr/Apj) attenuated Cdc42 activity and restored endothelial cell morphology and arteriovenous connection diameter in Rbpj-mutant brain vessels.

Conclusions:

Our data suggest that endothelial Rbpj promotes rearrangement of brain ECs during cerebrovascular remodeling, through Apelin/Apj-mediated small GTPase activity, and prevents bAVM. By inhibiting Apelin/Apj signaling in vivo, we demonstrated pharmacological prevention of Rbpj-mediated bAVM.
What (In)coherence Is Not
Authors: Fink Julian
Published: April 2023

Two or more attitudinal states are incoherent if and only if, necessarily, under conditions of full transparency, you are disposed to give up one of them. This is roughly the account of incoherence that has recently been put forward by Alex Worsnip (2018). In this article it is argued that Worsnip’s account of incoherence is incorrect. Not only does it fail to be fully general (i.e., it does not allow us to assess the coherence of all combinations of attitudes), but it also implies that an agent is necessarily incoherent just in virtue of being in one attitudinal state.
Rudolf Hallers Studien zu ästhetischen Grundlagenfragen
Authors: Cattaruzza Serena
Published: April 2023

In this essay, the highly original contribution made by Rudolf Haller to aesthetic studies and the philosophy of art is analysed. In particular, the volume Facta und Ficta (1986) is examined, which takes as its starting point the contrast between real and imaginary objects, including works of art. According to Haller, it is problematic to give a definition of a work of art because one can refer to very different creations, from poetic compositions to architectural structures and musical scores. Therefore, in post-Hegelian aesthetics, a dynamic consideration of art is important, which leaves room for empirical multiplicity and artistic variety without aprioristic preclusions.
Achnanthidium lucectorii sp. nov. and A. enigmaticum sp. nov., novel diatoms (Bacillariophyta, Achnanthidiaceae) from Texas, U.S.A.
Authors: MORALES EDUARDO A. , MANOYLOV KALINA M.
Published: April 2023

Two new species, Achnanthidium lucectorii sp. nov., belonging to the A. minutissimum complex (species with straight terminal raphe ends), and A. enigmaticum sp. nov., within the A. pyrenaicum complex (species with hooked terminal raphe fissures), are described from Texas, U.S.A. utilizing light and scanning electron microscopy. Achnanthidium lucectorii sp. nov. has a raphe valve with striae located toward the apices composed of polygonal areolae, a marked stauros, a non-expanded raphe fissure, with straight (non-dilated) proximal ends, and distal ends extending onto the valve mantle. Internally, its raphe valve is flat, the proximal ends of the raphe end in small capitate expansions, and the distal ends terminate in low helictoglossae that fuse with the apices by a low apical siliceous thickening. In turn, its sternum valve is unique in that it is mostly flat in inner view, except at the central nodule, which is slightly raised. In turn, A. enigmaticum sp. nov. externally has a raphe valve with raphe distal ends shaped like a closed hook, at these ends the raphe slit surfaces at the valve face/mantle junction; its axial area is raised in external and internal views, with the virgae and striae in a lower position. These and other traditionally considered features are compared in detail with taxa morphologically similar to each of the new species. The significance of these features is discussed based on a literature survey, and the implications of considering the valve surface topography and the external and internal details of the raphe and central area are assessed. The latter, in favor of a continued morphological exploration of Achnanthidium until molecular studies are appropriately integrated into current morphological approaches used in the taxonomy of the genus.
Salvia adiyamanensis (Lamiaceae), a new species from South East Anatolia, Turkey
Authors: İLÇİM AHMET , TEL AHMET ZAFER , KOCABAŞ YUSUF ZIYA
Published: April 2023

In this study, the new species Salvia adiyamanensis İlçim & Tel (Lamiaceae) is described from Adiyaman province, Turkey. The relevant diagnostic characters with respect to the species were presented. In addition, we presented the notes concerned with the ecology, habitat, conservation status, pollen and seed morphology of the species. We furthermore constructed a distribution map for the new species and other related species.
A new synonym of the newly described species Aster sanqingshanicus (Asteraceae)
Authors: LI TIAN , CHEN YOU-SHENG
Published: April 2023

N/A
Lecithoceridae (Lepidoptera) of Madagascar: I. Descriptions of eighteen new species of Torodora Meyrick, 1894
Authors: PARK KYU-TEK , KOO JUN-MO , MINET JOËL , RAZAFINDRANAIVO VICTOR
Published: April 2023

The present study is aimed at describing lecithocerid specimens from Madagascar collected by Pierre Viette and his colleagues during the 1950’s and preserved in the Muséum National d’Histoire Naturelle (MNHN, Paris). Eighteen new species of Torodora Meyrick, 1894 are described, namely: T. hana Park & Koo, sp. nov., T. larseni Park & Koo, sp. nov., T. toliarensis Park & Koo, sp. nov., T. silvestris Park & Koo, sp. nov., T. sogai Park & Koo, sp. nov., T. vietteiola Park & Koo, sp. nov., T. haploista Park & Koo, sp. nov., T. septentriella Park & Koo, sp. nov., T. zahamenensis Park & Koo, sp. nov., T. unicolorella Park & Koo, sp. nov., T. pistillia Park & Minet, sp. nov., T. andringitrensis Park & Minet, sp. nov., T. ochrizona Park & Minet, sp. nov., T. anosibensis Park & Minet, sp. nov., T. convexula Park & Minet, sp. nov., T. sphenosa Park & Minet, sp. nov., T. malagasiella Park & Minet, sp. nov., and T griveaudi Park & Minet, sp. nov. The previously unknown male of T. lecithocerella (Viette, 1956) is described for the first time. Adults and their male or female genitalia are illustrated.
Ecology determines appearance: a new taxonomic solution for the soft bottom dwelling spider crab Pisoides bidentatus (A. Milne-Edwards, 1873) from the Sea of Japan, with remarks on Pisoides ortmanni (Balss, 1924) and the northwestern Pacific Pugettia Dana, 1851 (Majoidea: Epialtidae)
Authors: MARIN IVAN N. , GOLUBINSKAYA DARYA D. , SHARINA SVETLANA N.
Published: April 2023

The northwestern Pacific soft bottom dwelling spider crab, Pisoides bidentatus (A. Milne-Edwards, 1873) (Brachyura: Majoidea: Epialtidae), is re-described using an integrative approach. As a result, it is transferred to the genus Scyra Dana, 1851 (Epialtidae) based on morphological and molecular data, as well as already described larval morphology, which certainly better reflects the phylogenetic relationships of the species. Japanese Pisoides ortmanni (Balss, 1924), for which morphology and ecology are very similar to P. bidentatus as well as Pugettia quadridens (De Haan, 1839) and the closely related Pugettia ferox Ohtsuchi & Kawamura, 2019, are also transferred to Scyra. The “reduced” morphology of both species is very different from the related northwestern Pacific Scyra spp. and Pugettia spp., which are mostly decorating algae-dwellers. We associate the relatively long ambulatory legs, a smooth tear-drop shaped carapace with a reduced dorsal armature and slightly pronounced pseudorostral spines, characteristic of P. bidentatus and P. ortmanni with their open soft (mainly sand) bottom habitats, where it is difficult to find a foothold or shelter, but it is necessary to resist constant currents. Such morphology is also characteristic of spider crabs of the genera Libinia Leach, 1815 and Doclea Leach, 1815 (Epialtidae: Pisinae), which are also living in similar habitats/conditions and represent a convergent morphological appearance.
Studies on Argentinean species of the Bahitini leafhopper genus Menosoma Ball, 1931 (Hemiptera: Cicadellidae); checklist, key to known species, and redescription of Menosoma taeniatum Linnavuori with a new country record
Authors: PINEDO-ESCATEL J. A. , BECERRA-CHIRON I. M. , TORRES-MORENO R.
Published: April 2023

The species of the genus Menosoma to occur in Argentina are revised. Menosoma taeniatum Linnavuori is redescribed using recent samples taken from Northeast Argentina. Overall habitus images of external and internal morphology are provided. In addition, a new country record is reported for Bolivia. An updated checklist and key to all Menosoma species known to occur in Argentina are also given.
Effects of Saharan Dust Aerosols and West African Precipitation on the Energetics of African Easterly Waves
Authors: Bercos-Hickey Emily , Nathan Terrence R. , Chen Shu-Hua
Published: April 2023

The effects of Saharan dust aerosols and West African precipitation on the seasonally averaged energetics of African easterly waves (AEWs) are examined using the Weather Research and Forecasting Model coupled to an interactive dust model. Four experiments are conducted: a control for the period July–September 2008, and three other experiments in which the dust emissions and precipitation are reduced separately and in combination. An analysis of the total energy shows the relative importance of the dust and precipitation to the seasonally averaged AEW strength and AEW tracks, which straddle the African easterly jet (AEJ). Changes in the dust amount have a larger effect on the strength of the AEWs than changes in the precipitation amount. The north AEW track is more strongly affected by changes in dust, while the south AEW track is more strongly affected by changes in precipitation. An analysis of the energy conversions aids in identifying the relative importance of the wave–mean flow interaction pathways that connect the dust and precipitation fields to the AEJ–AEW system. The analysis shows that the variability of the AEWs is primarily coupled to the dust- and precipitation-modified variability of the AEJ through wave–mean flow interaction. These results are discussed in light of tropical cyclone development over the eastern Atlantic Ocean.
Process-Oriented Diagnosis of Tropical Cyclones in Reanalyses Using a Moist Static Energy Variance Budget
Authors: Dirkes Caitlin A. , Wing Allison A. , Camargo Suzana J. , Kim Daehyun
Published: April 2023

Global models are frequently used for tropical cyclone (TC) prediction and climate projections but have biases in their representation of TCs that are not fully understood. The objective of this work is to assess how well and how robustly physical processes that are important for TC development are represented in modern reanalysis products and to consider whether reanalyses can serve as an observationally constrained reference against which model representation of these physical processes can be evaluated. Differences in the representation of large-scale environmental variables relevant to TC development do not readily explain the spread in TC climatologies across climate models, as found in prior work, or across reanalysis datasets, as shown here. This motivates the use of process-oriented diagnostics that focus on how convection, moisture, clouds, and related processes are coupled and can be used to identify areas to target for model improvement. Using the column-integrated moist static energy (MSE) variance budget, we analyze radiative and surface flux feedbacks across five different reanalyses. We construct an intensity-bin composite of the MSE variance budget to compare storms of similar intensity. Our results point to some fundamental differences across reanalyses in how they represent MSE variance and surface flux and radiative feedbacks in TCs, which could contribute to differences across reanalyses in how they represent TCs, but other factors also likely contribute. Any future work that evaluates these diagnostics in GCMs against reanalyses should do so cautiously, and efforts should be undertaken to provide a true observational estimate of these processes.
Subtractive clustering Takagi-Sugeno position tracking for humans by low-cost inertial sensors and velocity classification
Authors: Maton Dariusz , Economou John Theodoros , Galvão Wall David , Ward David , Trythall Simon
Published: April 2023

In this work, open-loop position tracking using low-cost inertial measurement units is aided by Takagi-Sugeno velocity classification using the subtractive clustering algorithm to help generate the fuzzy rule base. Using the grid search approach, a suitable window of classified velocity vectors was obtained and then integrated to generate trajectory segments. Using publicly available experimental data, the reconstruction accuracy of the method is compared against four competitive pedestrian tracking algorithms. The comparison on selected test data, has demonstrated more competitive relative and absolute trajectory error metrics. The proposed method in this paper is also verified on an independent experimental data set. Unlike the methods which use deep learning, the proposed method has shown to be transparent (fuzzy rule base). Lastly, a sensitivity analysis of the velocity classification models to perturbations from the training orientation at test time is investigated, to guide developers of such data-driven algorithms on the granularity required in an ensemble modeling approach. The accuracy and transparency of the approach may positively influence applications requiring low-cost inertial position tracking such as augmented reality headsets for emergency responders.
Dispensing and Purchasing Antibiotics Without Prescription: A Cross-sectional Study Among Pharmacists and Patients in Beirut, Lebanon
Authors: Kakati Rasha , Nakad Borrego Sanaa , Zareef Rana , Atallah Johnny , Farhat Souha , Daye Nahla , Sadek Sandra , Bardus Marco
Published: April 2023

Antimicrobial resistance is a global public health issue, exacerbated by dispensing and purchasing antibiotics without a prescription, common in low- and middle-income countries, such as Lebanon. This study aimed to (1) describe behavioral patterns underpinning dispensing and purchasing antibiotics without a prescription among pharmacists and patients, (2) describe reasons for, and (3) attitudes toward these behaviors. A cross-sectional study targeted pharmacists and patients, respectively, identified through stratified random sampling and convenience sampling from all 12 Beirut quarters. Questionnaires assessed behavioral patterns, reasons for, and attitudes toward dispensing and purchasing antibiotics without prescription among the 2 samples. A total of 70 pharmacists and 178 patients were recruited. About a third (37%) of pharmacists supported dispensing antibiotics without a prescription, considering it acceptable; 43% of patients report getting antibiotics without a prescription. Reasons for distributing and purchasing antibiotics without prescription include financial costs associated with the drugs and convenience, coupled with inexistent law enforcement. Dispensing antibiotics without prescription was shared among a relatively high proportion of pharmacists and patients residing in Beirut. Dispensing antibiotics without prescription is common in Lebanon, where law enforcement needs to be stronger. National efforts, including anti-AMR campaigns and law enforcement, must be rapidly implemented to avoid the double disease burden, especially when old and new vaccines are available, and superbugs are making preventative public health efforts more difficult.
Acrylic “lollipop” for jaw rehabilitation after release of joint ankylosis in paediatric patients
Authors: Uppal Nakul , Ansari Mohd. Naseemuddin , Dadsena Kamini , Xavier Frijo , Mithani Haseen
Published: April 2023

Falls are a leading cause of injuries to the temporomandibular joint (TMJ) in the paediatric age group. In low- and middle-income nations, after injury to a child's chin, a careful clinical examination of the mandible and TMJ is sometimes omitted. Paediatric mandibular condylar fractures tend to shatter the relatively narrow condylar head, leading to ankylosis to the skull base, which leads to debilitating progressive deformity. 1 Early surgical release is then the sole modality of treatment and needs to be followed up by several weeks of active mouth-opening exercises to prevent re-ankylosis, which are crucial in the immediate post-operative period. Unfortunately, as patient cooperation is low owing to uncomfortable jaw mobilization, we fabricated a simple acrylic appliance which is easy to use.
Rhinogenic Optic Neuropathy with No Light Perception Secondary to Onodi Cell Mucocele with Visual Recovery after Optic Nerve Decompression
Authors: Shaikh Noah , Nguyen John , Bailey Christopher Eric , Patel Ami , Ellis Brian , Makary Chadi A.
Published: April 2023

Rhinogenic optic neuropathy (RON) results from ethmoid or sphenoid sinus inflammation or infection causing optic nerve impairment.1Treatment often requires endoscopic surgery and vision restoration occurs in select cases. There is no clear evidence for the benefit of optic nerve decompression (OND) in these situations. We present a unique case of RON caused by an Onodi cell mucocele for which isolated endoscopic mucocele drainage was not enough and further OND was needed to improve vision.
Hysteroscopic presentation of endometrial vascular dystrophy: a case report
Authors: Jiang SuZhen , Gong HongXia
Published: April 2023

Endometrial vascular dystrophy is quite rare, and there is very little literature regarding this subject. We present the unusual case of a 38-year-old woman who experienced vaginal bleeding after menstruation for 3 months. Hysteroscopically, the uterine cavity was filled with tiny, curved blood vessels, the bottom of the cavity was obvious, and polyps were visible. No curved vessels or polyps were identified after curettage. The diagnosis was endometrial hemodystrophy with endometrial polyps. Endometrial vascular dystrophy is a hysteroscopically uncommon benign lesion of the endometrial vessels.
Clinical application of three-dimensional T1-weighted BrainVIEW in magnetic resonance imaging of cerebral venous thrombosis: a case report and literature review
Authors: Yang Cheng , Fang Huang , Hu Jun , Li Mei , Wei Chunxia , Miao Jinfei , Huang Wencai
Published: April 2023

To date, there is no clinical scoring system or laboratory indicator that can rule out cerebral venous thrombosis (CVT) or provide diagnostic proof for evaluating post-treatment thrombosis recanalization during follow-up. We therefore explored an imaging method for quantitative assessment of CVT and assessed thrombotic changes during follow-up. A patient presented with severe posterior occipital distension extending to the top of the forehead and an elevated plasma D-dimer (DD2) level. Computed tomography and pre-contrast-enhanced magnetic resonance imaging revealed only a small amount of cerebral hemorrhage. Three-dimensional (3D) T1-weighted (T1W) BrainVIEW pre-contrast-enhanced magnetic resonance scanning showed subacute thrombosis in the venous sinus, and the post-contrast-enhanced scan combined with volume rendering reconstruction showed cerebral thrombosis of the venous sinus and allowed for measurement of the thrombus volume. On days 30 and 60 of post-treatment follow-up, post-contrast-enhanced scans showed progressive reduction of the thrombus volume as well as recanalization and fibrotic flow voids in the chronic thrombosis. 3D T1W BrainVIEW was helpful to observe the size of the thrombi and the situation of venous sinus recanalization during the follow-up after clinical treatment of CVT. This technique can reflect the imaging manifestations of CVT throughout the whole process to guide clinical treatment decisions.
Investigating mechanical engineering students’ approaches to opportunity recognition process
Authors: Shekhar Prateek , Dominguez Heydi , Lee Jin Woo , Augustin Samantha
Published: April 2023

The process of opportunity recognition is pivotal to engineering design, fostering technological innovation and entrepreneurship. Although there are multiple studies conducted in the area of opportunity recognition studying the behaviors of entrepreneurs, examining engineering students’ approaches have been underexplored. There is a lack of research in regards to opportunity recognition processes among engineering students, particularly in the context of design education. The presented study addresses this gap by qualitatively examining approaches to opportunity recognition among mechanical engineering students enrolled in an engineering design course. Using a sample of 23 mechanical engineering students, the approaches to opportunity recognition were analyzed using students’ responses to open-ended survey questions and student group discussions. From the analysis of the qualitative data, four key themes emerged regarding the improvement of the device and process, user consideration, environmental sustainability, and information and resources accessed by students. The findings provide a deeper understanding that can be used to inform educational practices and further research in the area of opportunity recognition in engineering education settings.
Oxygenation performance assessment of an artificial lung in different central anatomic configurations
Authors: Hima Flutura , Kalverkamp Sebastian , Kashefi Ali , Mottaghy Khosrow , Zayat Rachad , Strudthoff Lasse , Spillner Jan , Mouzakis Foivos
Published: April 2023

Objectives:

Aim of this work was to characterize possible central anatomical configurations in which a future artificial lung (AL) could be connected, in terms of oxygenation performance.

Methods:

Pulmonary and systemic circulations were simulated using a numerical and an in vitro approach. The in vitro simulation was carried out in a mock loop in three phases: (1) normal lung, (2) pulmonary shunt (50% and 100%), and (3) oxygenator support in three anatomical configurations: right atrium-pulmonary artery (RA-PA), pulmonary artery-left atrium (PA-LA), and aorta-left atrium (Ao-LA). The numerical simulation was performed for the oxygenator support phase. The oxygen saturation (SO2) of the arterial blood was plotted over time for two percentages of pulmonary shunt and three blood flow rates through the oxygenator.

Results:

During the pulmonary shunt phase, SO2 reached a steady state value (of 68% for a 50% shunt and of nearly 0% for a 100% shunt) 20 min after the shunt was set. During the oxygenator support phase, physiological values of SO2 were reached for RA-PA and PA-LA, in case of a 50% pulmonary shunt. For the same conditions, Ao-LA could reach a maximum SO2 of nearly 60%. Numerical results were congruous to the in vitro simulation ones.

Conclusions:

Both in vitro and numerical simulations were able to properly characterize oxygenation properties of a future AL depending on its placement. Different anatomical configurations perform differently in terms of oxygenation. Right to right and right to left connections perform better than left to left ones.
Extracorporeal life support in pregnant and postpartum women with COVID-19-related acute respiratory distress syndrome
Authors: El Banayosy Ahmed M , El Banayosy Aly , Smith Jennifer G , Brewer Joseph M , Mihu Mircea R , Swant Laura V , Schoaps Robert S , Sharif Ammar , Benson Clayne , Maybauer Marc O
Published: April 2023

Objective:

Extracorporeal membrane oxygenation (ECMO) is an intervention used for patients with acute respiratory distress syndrome (ARDS) from COVID-19 who have failed conventional ventilatory strategies. Very few studies have given insight into the outcomes of pregnant and postpartum patients requiring ECMO support.

Methods:

Single center, retrospective, observational study of female pregnant and postpartum patients suffering COVID-19 ARDS and requiring ECMO.

Results:

Eight SARS-CoV-2 positive patients were identified. The average age was 31 ± 4 years, with Body Mass Indices (BMI) and SOFA scores ranging between 32–49 and 8–11, respectively. Two patients were pregnant at the time of ECMO initiation, two were peripartum, and four were postpartum. Five patients (63%) had bleeding, and one patient had a hysterectomy. Seven patients (88%) were supported by V-V ECMO and one with V-A ECMO. Patients had between one and three circuit exchanges due to oxygenator failure or clots in the circuit. All patients were in ICU between 7 and 74 days, with hospital length of stay between 8 and 81 days. All patients were weaned off ECMO and were successfully discharged from the hospital. All newborns were born via cesarean section, and all survived to discharge.

Conclusion:

Our study shows a 100% neonatal and maternal survival rate demonstrating that ECMO in this patient population is safe. These patients should be transferred to experienced high-volume ECMO centers with the ability to perform emergent cesarean sections. ECMO should be considered a life-saving therapy for pregnant women with severe COVID-19 with an overall excellent maternal and neonatal survival rate.
Brand Management of Natural Spaces: The Impact of Natural Space Authenticity on Consumer Outcomes
Authors: Matthews A. Lynn , Cockrell Seth , Walker Kristen L.
Published: April 2023

Perceived authenticity of publicly owned natural parks is an important yet often overlooked driver of consumer experience, enjoyment, and well-being. Given the U.S. National Park Service's charge to operate parks for the enjoyment of the public while conserving them for the future, it is important for park agencies to understand how visitors perceive the authenticity of parks and how they can increase perceived authenticity of the spaces they manage. The authors use the construct of brand authenticity as the foundation of a natural space authenticity framework and draw on attention restoration theory to highlight the importance of viewing the marketing of natural spaces as a form of brand management. In a survey of 2,646 visitors to state parks and a series of three experiments, the authors examine the impact of natural space authenticity (perceived continuity, credibility, and symbolism) on consumer outcomes. Findings indicate that these three dimensions of natural space authenticity improve outcomes of return visit intentions, recommendation intentions, decreased stress, and perceived health for prior and potential visitors of state parks. The authors present managerial and policy implications to assist park managers and guide future research.
Prognostic Value of Diaphragm Diameter, Muscle Volume, and Bone Mineral Density in Critically Ill COVID-19 Patients
Authors: Emekli Emre , Bostancı Can Emine Zülal
Published: April 2023

Objective: We aimed to analyze the prognostic value of muscle volume (MV), bone mineral density (BMD), and diaphragm diameter (DD) in COVID-19. Method: The study included 498 patients admitted to the intensive care unit (ICU) with a positive polymerase chain reaction test for COVID-19 from March 11, 2020, through August 31, 2022. The patients’ laboratory and demographic data of the patients at the time of ICU admission were recorded. MV, DD, and BMD measurements were performed using computed tomography examinations. Muscle index (MI) was calculated as MV/height2. Quartiles were determined for all 4 measurements. Patients in the lowest quartile were recorded as having low MV, MI, DD, and BMD values. The parameters were evaluated for the whole group and compared according to gender and mortality. The multiple regression analysis was performed for the prediction of mortality. Results: In the mortality group, the male and female patients had significantly statistically lower values in MV ( P < .001 and P = .002, respectively), MI ( P < .001 and P = .005, respectively), DD ( P < .001 and P < .001, respectively), and BMD ( P = .002 and P < .001, respectively). In the multiple regression analysis, low MI (OR: 2.03, 95% CI: 1.14-3.61, P = .016) and DD (OR: 10.47, 95% CI: 5.59-19.59, P < .001) values remained significant for the prediction of mortality. Conclusion: BMD is a risk factor for mortality in patients with severe COVID-19, but cannot be used as an independent predictor. However, MI and DD can be used as independent predictors of mortality even in severe cases.
Adaptive sliding mode control for robotic manipulators with backlash
Authors: Chen Jiqing , Tang Qingsong , Zhao Chaoyang , Zhang Haiyan
Published: April 2023

This paper provides the consequences for trajectory tracking of uncertain n-DOF robotic manipulators in the presence of external disturbances and backlash. The control strategy consists of decoupling system based on inverse dynamics, sliding mode controller, and optimal controller. The tendency of robotic manipulators with gear backlash is to function in two unique phases: contact phase or backlash phase. The sliding mode controller works in the contact phase, after the decoupling of the manipulator, a adaptive second-order sliding mode controller is designed to guarantee system achieve desirable tracking precision and robust stability. The optimal controller works in the backlash phase, which makes the motor quickly traverse the backlash gap and re-contact the joints without collision. Finally, the proposal is verified in simulation using a model of a PUMA560 robot manipulator identified from real data.