bluuebunny/crossref_metadata_2025 huggingface dataset:
Key Challenges for High Temperature Thermal Energy Storage in Concrete—First Steps towards a Novel Storage Design
Authors: Cabeza Luisa F. , Vérez David , Zsembinszki Gabriel , Borri Emiliano , Prieto Cristina
Published: June 2022

Thermal energy storage (TES) allows the existing mismatch between supply and demand in energy systems to be overcome. Considering temperatures above 150 °C, there are major potential benefits for applications, such as process heat and electricity production, where TES coupled with concentrating solar power (CSP) plants can increase the penetration of renewable energies. To this end, this paper performs a critical analysis of the literature on the current and most promising concrete energy storage technologies, identifying five challenges that must be overcome for the successful exploitation of this technology. With these five challenges in mind, this paper proposes an approach that uses a new modular design of concrete-based TES. A preliminary study of the feasibility of the proposed system was performed using computational fluid dynamics (CFD) techniques, showing promising results.
Assessing the Genetic Identity of Tuscan Sweet Chestnut (Castanea sativa Mill.)
Authors: Cavallini Marta , Lombardo Gianluca , Binelli Giorgio , Cantini Claudio
Published: June 2022

The sweet chestnut (Castanea sativa Mill.) is an important species of European trees, studied for both ecological and economic reasons. Its cultivation in the Italian peninsula can be linked to the Roman period and has been documented, especially in the Tuscan region, for centuries. We sampled 131 grafted trees from three separate areas to determine the genetic variability between populations and assess genetic identity for different varieties of trees, which is useful for future breeding programs and propagation efforts. Molecular analyses were performed using eight microsatellite loci. A total of 98 alleles was detected with an average of 12.3 alleles per locus. We found high levels of genetic diversity within the varieties of the same area, ranging between He = 0.682–0.745. Of the eight loci, seven were found to be at Hardy-Weinberg equilibrium. (FST values Differentiation between cultivation areas was significant between 0.052–0.147) with the two Southern Tuscan areas showing the closest relationship as also indicated by Bayesian inference of the population structure, which revealed the existence of three ancestral gene pools of origin. Demographic events were detected by a coalescent-based approximate Bayesian computation in two of the homogeneous clusters. This work is a step forward for the conservation of this iconic species, albeit at a regional level, as chestnut varieties have never received the full attention of breeders.
First Report of Dutch Elm Disease Caused by Ophiostoma novo-ulmi in South Korea
Authors: Lee Dong-Hyeon , Nam Youngwoo , Wingfield Michael J. , Park Hyungcheol
Published: June 2022

During a routine survey conducted in July 2021, several dead and dying Ulmus macrocarpa trees were observed in an urban forest located in the Gyeonggi Province of South Korea. The trees had symptoms of wilt with yellowing and browning of leaves, and, in most cases, the trunks of dying trees were infested by bark beetles. Isolations were made from small pieces of wood taken from dying trees, and beetles were collected from the infested stems. Fungal isolates and the beetles were identified using DNA sequence-based phylogenies and morphology, respectively. The results revealed that the fungus was Ophiostoma novo-ulmi, the causal agent of Dutch elm disease, and the associated bark beetle was Scolytus jacobsoni. This study provides the first record of Dutch elm disease in South Korea and suggests that a nationwide survey for the disease should be undertaken.
Tracheidogram’s Classification as a New Potential Proxy in High-Resolution Dendroclimatic Reconstructions
Authors: Zharkov Mikhail S. , Huang Jian-Guo , Yang Bao , Babushkina Elena A. , Belokopytova Liliana V. , Vaganov Eugene A. , Zhirnova Dina F. , Ilyin Victor A. , Popkova Margarita I. , Shishov Vladimir V.
Published: June 2022

Quantitative wood anatomy (QWA) is widely used to resolve a fundamental problem of tree responses to past, ongoing and forecasted climate changes. Potentially, QWA data can be considered as a new proxy source for long-term climate reconstruction with higher temporal resolution than traditional dendroclimatic data. In this paper, we considered a tracheidogram as a set of two interconnected variables describing the dynamics of seasonal variability in the radial cell size and cell wall thickness in conifer trees. We used 1386 cell profiles (tracheidograms) obtained for seven Scots pine (Pinus sylvestris) trees growing in the cold semiarid conditions of Southern Siberia over the years 1813–2018. We developed a “deviation tracheidogram” approach for adequately describing the traits of tree-ring formation in different climate conditions over a long-term time span. Based on the NbClust approach and K-means method, the deviation tracheidograms were reliably split into four clusters (classes) with clear bio-ecological interpretations (from the most favorable growth conditions to worse ones) over the years 1813–2018. It has been shown that the obtained classes of tracheidograms can be directly associated with different levels of water deficit, for both the current and previous growing seasons. The tracheidogram cluster reconstruction shows that the entire 19th century was characterized by considerable water deficit, which has not been revealed by the climate-sensitive tree-ring chronology of the study site. Therefore, the proposed research offers new perspectives for better understanding how tree radial growth responds to changing seasonal climate and a new independent proxy for developing long-term detailed climatic reconstructions through the detailed analysis of long-term archives of QWA data for different conifer species and various forest ecosystems in future research.
Optimal Survey Design for Forest Carbon Monitoring in Remote Regions Using Multi-Objective Mathematical Programming
Authors: Tóth Sándor F. , Oken Kiva L. , Stawitz Christine C. , Andersen Hans-Erik
Published: June 2022

Cost-effective monitoring of forest carbon resources is critical to the development of national policies and enforcement of international agreements aimed at reducing carbon emissions and mitigating the impacts of climate change. While carbon monitoring systems are often based on national forest inventories (NFI) utilizing a large sample of field plots, in remote regions the lack of transportation infrastructure often requires heavier reliance on remote sensing technologies, such as airborne lidar. The challenge motivating our research is that the efficacy of estimating carbon with lidar varies across the various carbon pools within forest ecosystems. Lidar measurements are typically highly correlated with aboveground tree carbon but are less strongly correlated with other carbon pools, such as down woody materials (DWM) and soil. Field measurements are essential to both (1) estimate soil and DWM carbon directly and (2) develop regression models to estimate tree carbon indirectly using lidar. With limited budgets and time, however, decision makers must find an optimal way to combine field measurements with lidar to minimize standard errors in carbon estimates for the various pools. We introduce a multi-objective binary programming formulation that quantifies the tradeoffs behind the competing objectives of minimizing standard errors for tree carbon, DWM carbon, and soil carbon. Using NFI and airborne lidar data from a remote boreal forest region of interior Alaska, we demonstrate the operational feasibility of the method and suggest that it is generalizable to other carbon sampling projects because of its generic mathematical structure.
Ecological Strategy Spectra for Communities of Different Successional Stages in the Tropical Lowland Rainforest of Hainan Island
Authors: Chen Chen , Wen Yabo , Ji Tengyue , Zhao Hongxia , Zang Runguo , Lu Xinghui
Published: June 2022

Plant ecological strategies are shaped by long-term adaptation to the environment and are beneficial to plant survival and reproduction. Research is ongoing to better understand how plants best allocate resources for growth, survival and reproduction, as well as how ecological strategies may shift in plant communities over the course of succession. In this study, 12 forest dynamics plots in three different successional stages were selected for study in the tropical lowland rainforest ecosystem of Hainan Island. For each plot, using Grime’s competitor, a stress-tolerator, the ruderal (CSR) scheme and using the CSR ratio tool “StrateFy”, an ecological strategy spectrum was constructed using functional trait data obtained by collecting leaf samples from all woody species. The ecological strategy spectra were compared across successional stages to reveal successional dynamics. The results showed: (1) The ecological strategy spectra varied among forest communities belonging to three different successional stages. (2) The community-weighted mean CSR (CWM-CSR) strategies shifted with succession: CWM-S values decreased, while the CWM-C and CWM-R values increased. Overall, shifts in plant functional traits occurred slowly and steadily with succession showing complex and diverse trade-offs and leading to variation among the ecological strategy spectra of different successional stages.
Party Formation and Coalitional Bargaining in a Model of Proportional Representation
Authors: Bandyopadhyay Siddhartha , Oak Mandar
Published: June 2022

We study a game theoretic model of a parliamentary democracy under proportional representation where ideologically motivated citizen groups form parties, voting occurs and governments are formed. We study the coalition governments that emerge as functions of the parties’ seat shares, the size of the rents from holding office and their ideologies. We show that governments may be minimal winning, minority or surplus. Moreover, coalitions may be ‘disconnected’. We then look at how the coalition formation game affects the incentives for party formation. In particular, we show that when the rents from office are low, the median citizen stands unopposed, and when rents are high, there is more political entry. For intermediate rents, we show that strategic dropouts can happen to influence the final policy. We show that the incentives for strategic dropout can be higher under proportional representation than plurality voting, contrary to Duverger’s law. Our model explains the diverse electoral outcomes seen under proportional representation and integrates models of political entry with models of coalitional bargaining.
A Possible Cause for the Differential Expression of a Subset of miRNAs in Mesenchymal Stem Cells Derived from Myometrium and Leiomyoma
Authors: Di Vincenzo Mariangela , De Quattro Concetta , Rossato Marzia , Lazzarini Raffaella , Delli Carpini Giovanni , Ciavattini Andrea , Orciani Monia
Published: June 2022

The aetiology of leiomyoma is debated; however, dysregulated progenitor cells or miRNAs appear to be involved. Previous profiling analysis of miRNA in healthy myometrium- (M-MSCs) and leiomyoma- (L-MSCs) derived mesenchymal stem cells (MSCs) identified 15 miRNAs differentially expressed between M-MSCs and L-MSCs. Here, we try to elucidate whether these differentially regulated 15 miRNAs arise as a conversion of M-MSCs along the differentiation process or whether they may originate from divergent cell commitment. To trace the origin of the dysregulation, a comparison was made of the expression of miRNAs previously identified as differentially regulated in M-MSCs and L-MSCs with that detected in MSCs from amniotic fluid (considered as a substitute for embryonic cells). The results do not allow for a foregone conclusion: the miRNAs converging to the adherens junction pathway showed a gradual change along the differentiation process, and the miRNAs which coincided with the other three pathways (ECM-receptor interaction, TGFβ and cell cycle) showed a complex, not linear, regulation and, therefore, a trend along the hypothetical differentiation process was not deduced. However, the role of miRNAs appears to be predominant in the onset of leiomyoma and may follow two different mechanisms (early commitment; exacerbation); furthermore, miRNAs can support the observed (epigenetic) predisposition.
Mutation of foxl1 Results in Reduced Cartilage Markers in a Zebrafish Model of Otosclerosis
Authors: Hawkey-Noble Alexia , Pater Justin A. , Kollipara Roshni , Fitzgerald Meriel , Maekawa Alexandre S. , Kovacs Christopher S. , Young Terry-Lynn , French Curtis R.
Published: June 2022

Bone diseases such as otosclerosis (conductive hearing loss) and osteoporosis (low bone mineral density) can result from the abnormal expression of genes that regulate cartilage and bone development. The forkhead box transcription factor FOXL1 has been identified as the causative gene in a family with autosomal dominant otosclerosis and has been reported as a candidate gene in GWAS meta-analyses for osteoporosis. This potentially indicates a novel role for foxl1 in chondrogenesis, osteogenesis, and bone remodelling. We created a foxl1 mutant zebrafish strain as a model for otosclerosis and osteoporosis and examined jaw bones that are homologous to the mammalian middle ear bones, and mineralization of the axial skeleton. We demonstrate that foxl1 regulates the expression of collagen genes such as collagen type 1 alpha 1a and collagen type 11 alpha 2, and results in a delay in jawbone mineralization, while the axial skeleton remains unchanged. foxl1 may also act with other forkhead genes such as foxc1a, as loss of foxl1 in a foxc1a mutant background increases the severity of jaw calcification phenotypes when compared to each mutant alone. Our zebrafish model demonstrates atypical cartilage formation and mineralization in the zebrafish craniofacial skeleton in foxl1 mutants and demonstrates that aberrant collagen expression may underlie the development of otosclerosis.
Genetic Analyses of Discrete Geographic Samples of a Golden Chanterelle in Canada Reveal Evidence for Recent Regional Differentiation
Authors: Zhao Kuan , Korfanty Gregory A. , Xu Jianping , Thorn R. Greg
Published: June 2022

The wild edible mushroom Cantharellus enelensis is a recently described species of the golden chanterelles found in eastern North America. At present, the genetic diversity and population structure of C. enelensis are not known. In this study, we analyzed a total of 230 fruiting bodies of C. enelensis that were collected from three regions of Canada: near the east and west coasts of Newfoundland (NFLD), with 110 fruiting bodies each, and around Hamilton, Ontario (10 fruiting bodies). Among the 110 fruiting bodies from each coast in NFLD, 10 from 2009 were without specific site information, while 100 sampled in 2010 were from each of five patches separated by at least 100 m from each other. Each fruiting body was genotyped at three microsatellite loci. Among the total 28 multilocus genotypes (MLGs) identified, 2 were shared among all three regions, 4 were shared between 2 of the 3 regions, and the remaining 22 were each found in only 1 region. Minimal spanning network analyses revealed several region-specific MLG clusters, consistent with geographic specific mutation and expansion. Though the most frequently observed MLGs were shared among local (patch) and regional populations, population genetic analyses revealed that both local and regional geographic separations contributed significantly to the observed genetic variation in the total sample. All three regional populations showed excess heterozygosity; for the eastern NFLD population, we reject the null hypothesis of Hardy–Weinberg equilibrium (HWE) at all three loci. However, the analyses of clone-corrected samples revealed that most loci were in HWE. Together, our results suggest that the three discrete regional populations of C. enelensis were likely colonized from a common refugium since the last ice age. However, the local and regional populations are diverging from each other through mutation, drift, and selection at least partly due to heterozygous advantage.
Are Measures of Health Status for the Total Population Good Proxies for the Health of the Older Population in International Comparison Studies?
Authors: Kocot Ewa , Denkowska Sabina , Fijorek Kamil
Published: June 2022

In the face of population aging, the health of older people is becoming especially important, impacting various areas of life, societies and countries’ economies. To provide the basis for effective decisions to achieve better health, comparative analyses can be used to find best practices to follow. The aim of the research was to check whether drawing conclusions about the older population’s health based on the health status of the total population is justified in international comparison analyses. An analysis was conducted for six population health indicators for European countries from 2010–2019. Rankings were created for the total population and the older subpopulation, and then ranks for these two populations were compared using statistical methods. The statistical analyses indicate that there is a strong, statistically significant relationship between the ranks for the total and the older population. However, looking at the descriptive analysis and visual presentation of data, differences in international rankings of indicator values for these two populations can be observed. As older people comprise a specific group of the population that is growing ever bigger and increasingly significant, it would be advisable to present the results of international comparisons not only for the total, but separately for the older population as well.
Reply to Guidotti, T. Comment on “Laroche, E.; L’Espérance, S. Cancer Incidence and Mortality among Firefighters: An Overview of Epidemiologic Systematic Reviews. Int. J. Environ. Res. Public Health 2021, 18, 2519”
Authors: Laroche Elena , L’Espérance Sylvain
Published: June 2022

We have reviewed the comment [...]
Mindful Parenting Intervention MinUTo App for Parents of Preschool Children: Study Protocol of a Randomised Controlled Trial
Authors: Guarini Annalisa , Sansavini Alessandra , Suttora Chiara , Bortolotti Stefania , Fort Margherita , Iorio Daniela , Monfardini Chiara , Bigoni Maria
Published: June 2022

Background: Mindful parenting and the use of technology for parenting intervention have expanded separately from one another with promising results, but their relationship is underexplored. The current study protocol proposes a new universal intervention via app, MINd Us TOghether (MinUTo), based on mindful parenting for parents of typically developing children of 4–5 years of age. Methods: The effect of the intervention is evaluated using a randomised controlled trial. Around 2000 parents are enrolled and randomised to the intervention and control groups. Data are collected in three different waves from parents at baseline and endline; APP usage data allow for the analysis of intervention adherence. The MinUTo app proposes contents and activities for five dimensions of mindful parenting. Each dimension is presented within a two-week distance, explaining its importance, providing information, and offering activities for parents and children. Expected results: We hypothesise a positive effect of the intervention on primary outcomes (mindful parenting, parenting stress, parent behaviours and parental time investment), increasing parents’ skills and promoting a positive parent–child relationship. We also test possible effects on secondary outcomes (parenting attitudes and beliefs) at an explorative level. Conclusions: The study will add new considerations about the psychological and economic impact of technologies in implementing parenting interventions in non-clinical populations.
Social Network Analysis on the Mobility of Three Vulnerable Population Subgroups: Domestic Workers, Flight Crews, and Sailors during the COVID-19 Pandemic in Hong Kong
Authors: Yu Weijun , Alipio Cheryll , Wan Jia’an , Mane Heran , Nguyen Quynh C.
Published: June 2022

Background: Domestic workers, flight crews, and sailors are three vulnerable population subgroups who were required to travel due to occupational demand in Hong Kong during the COVID-19 pandemic. Objective: The aim of this study was to explore the social networks among three vulnerable population subgroups and capture temporal changes in their probability of being exposed to SARS-CoV-2 via mobility. Methods: We included 652 COVID-19 cases and utilized Exponential Random Graph Models to build six social networks: one for the cross-sectional cohort, and five for the temporal wave cohorts, respectively. Vertices were the three vulnerable population subgroups. Edges were shared scenarios where vertices were exposed to SARS-CoV-2. Results: The probability of being exposed to a COVID-19 case in Hong Kong among the three vulnerable population subgroups increased from 3.38% in early 2020 to 5.78% in early 2022. While domestic workers were less mobile intercontinentally compared to flight crews and sailors, domestic workers were 1.81-times in general more likely to be exposed to SARS-CoV-2. Conclusions: Vulnerable populations with similar ages and occupations, especially younger domestic workers and flight crew members, were more likely to be exposed to SARS-CoV-2. Social network analysis can be used to provide critical information on the health risks of infectious diseases to vulnerable populations.
Psychological and Physical Changes Caused by COVID-19 Pandemic in Elementary and Junior High School Teachers: A Cross-Sectional Study
Authors: Wakui Nobuyuki , Noguchi Nanae , Ichikawa Kotoha , Togawa Chikako , Matsuoka Raini , Yoshizawa Yukiko , Shirozu Shunsuke , Suzuki Kenichi , Ozawa Mizue , Yanagiya Takahiro , Kikuchi Mayumi
Published: June 2022

This study aimed to determine psychological and physical differences in elementary and junior high school teachers during COVID-19. This questionnaire-based cross-sectional study was conducted among 427 teachers in Tokyo, Japan (between 15 and 30 October 2020). The questionnaire explored school type (elementary and middle schools), sex, age, and COVID-19 changes (psychological changes, physical changes, impact on work, and infection control issues perceived to be stressed). Post hoc tests for I cannot concentrate on work at all, found a significant difference for no change–improved and male teacher in elementary school female teacher in junior high school (p = 0.03). Regarding stress situation due to implementation of COVID-19 infection control, there were significant differences for disinfection work by teachers between male teachers in elementary school female teachers in junior high school (p = 0.04) and female teachers in elementary school female teachers in junior high school (p = 0.03). COVID-19 produced differences in psychological and physical changes between male and female teachers in elementary and junior high schools. Some experienced psychological and physical stress, whereas others showed improvement. Given that teachers’ mental health also affects students’ educational quality, it is important to understand and improve teachers’ psychological and physical circumstances and stress.
Examining the Factors That Affect the Diagnosis of Patients with Positive Fecal Occult Blood Test Results
Authors: Cheng Yin-Wen , Li Ying-Chun
Published: June 2022

Due to the threat of colorectal cancer (CRC) to health, Taiwan included the fecal occult blood test (FOBT) under preventive health services in 2010. We examined the factors that affect the diagnosis of people with positive FOBT results. Data were retrospectively collected from the CRC screening database. In the model predicting factors that affect the diagnosis of 89,046 people with positive FOBT results, the risks of disease in the CRC group were lower in medical institutions that conducted follow-up examinations in regions such as Northern Taiwan compared to that in Eastern Taiwan (p = 0.013); they were lower in the age group of 50 to 65 years than those in the age group of 71 to 75 years (p < 0.001, p = 0.016), and lower in the outpatient medical units that conducted follow-up examinations than those in the inpatient medical units by 0.565 times (p < 0.001, 95% CI: 0.493–0.647). Factors affecting the diagnosis of patients with positive FOBT results were gender, the region of the medical institution, medical unit for follow-up examinations, age, screening site, family history, type of follow-up examinations, and follow-up time. Therefore, the identification of characteristics of patients with positive FOBT results and the promotion of follow-up examination are important prevention strategies for CRC.
The Effect of Medical Choice on Health Costs of Middle-Aged and Elderly Patients with Chronic Disease: Based on Principal-Agent Theory
Authors: Li Dongxu , Su Min , Guo Xi , Zhang Weile , Zhang Tianjiao
Published: June 2022

(1) Background: The discussion on how to reduce the health costs of chronic disease patients has become an important public health issue. Limited research has been conducted on how chronic disease patients’ medical choice of public and private medical institutions affect health costs. (2) Methods: This study used the panel data composed of the China Health and Retirement Longitudinal Survey (CHARLS) from 2011 to 2018, adopted the quasi-natural experimental research method, and set up a control group and an experimental group that chose public medical institutions and private medical institutions, to analyze the association between the medical choice and health costs of chronic disease patients. (3) Results: Compared with chronic disease patients who chose private medical institutions, patients who chose public medical institutions increased their total cost by 44.9%, total out-of-pocket cost by 22.9%, and decreased the total out-of-pocket ratio by 0.117%, total drug cost out-of-pocket ratio by 0.075%, and drug cost ratio by 0.102%. (4) Conclusions: According to the triple principal-agent relationships, the resource advantages given by the government to public medical institutions, the salary incentive system of medical institutions, and the information asymmetry advantage held by physicians may be important factors for the increase in health costs for chronic disease patients.
Exploring the Impacts of Preventative Health Behaviors with Respect to COVID-19: An Altruistic Perspective
Authors: Luo Yi-Fang , Yang Shu-Ching , Hung Shih-Chieh , Chou Kun-Yi
Published: June 2022

This study aims to explore the impact of gender and anxiety on various preventative health behaviors, and the relationships among these preventative health behaviors, individual well-being and depression, from the perspective of altruism. This study employed an online questionnaire survey, and 136 males and 204 females participated in the survey. The results of this study showed that females exhibited better preventative health behaviors than males, including hygiene habits, social distancing and behaviors intended to help others mitigate the epidemic. Anxiety regarding COVID-19 infection encouraged individuals to adopt hygienic habits and social distancing measures rather than to help others mitigate the epidemic. Hygiene habits improved the individual’s psychological well-being. Helping others mitigate the epidemic improved the individual’s psychological well-being and social well-being and contributed to reducing individual depression. However, the preventative health behavior involved in social distancing was not conducive to emotional well-being or social well-being. Affective elements are related to individual behaviors. Therefore, the use of prosocial, altruistic language may play an important role with respect to encouraging people to comply with preventative health behaviors in the context of COVID-19. In addition, it is worth noting that different preventative health behaviors may have different effects on people’s mental health, especially when implementing social distancing-related epidemic mitigation behaviors. The question of how to prevent negative psychological effects in restricted actors must be answered, and the degree of life satisfaction experienced by those actors must also be taken into account.
Ultra-Orthodox Lesbian Women in Israel: Alternative Family Structures as a Bridge between Religious and Sexual Identities
Authors: Ben Shlomo Shirley , Oreg Ayelet
Published: June 2022

The Jewish ultra-Orthodox community enforces strict rules concerning its members’ way of life and demands that their identities be consistent with that of this conservative community. However, such congruence does not exist for ultra-Orthodox women who identify as lesbians. Drawing on social representation theory, this study examines the unique family structures that lesbian ultra-Orthodox women in Israel have adopted to accommodate their conflicting identities. The study employed a qualitative multiple case study design, conducting in-depth interviews with seven ultra-Orthodox lesbian women, and adopted a phenomenological approach to learn about their lived experience. The women had all married young in arranged marriages and all had children. Four of them were still married, while the other three were divorced. In all cases, however, their lesbian identity was kept hidden. The findings reveal the unique family structures these women created that allowed them to maintain their religious way of life on the surface, while remaining committed to their sexual identity in secret. The study extends the social representation theory and promotes an understanding of the multifaceted identity of ultra-Orthodox lesbian women. The findings can aid in designing interventions that can help such women cope with the secret aspects of their life.
Erectile Dysfunction in Relation to Metabolic Disorders and the Concentration of Sex Hormones in Aging Men
Authors: Aleksandra Rył , Aleksandra Szylińska , Iwona Rotter
Published: June 2022

Background: The aim of this study was to analyze the relationship between the prevalence of erectile dysfunction in men as diagnosed by the International Index of Erectile Function (IIEF) questionnaire and the respective levels of sex hormones and biochemical parameters, as well as indices of visceral fat accumulation and activity. Material and Methods: The study comprised 148 male (60–75 years) patients from primary care outpatient clinics in the city of Szczecin (Poland). The men were asked to complete a shortened survey questionnaire with sociodemographic data, as well as a shortened version of the IIEF (five items). Venous blood samples were collected. Total testosterone (TT), estradiol (E2), sex hormone-binding globulin (SHBG), dehydroepiandrosterone sulfate (DHEAS), total cholesterol (ChT), low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides (TG), fasting plasma glucose (FPG) and albumin were determined. Lipid accumulation product (LAP) and visceral adiposity index (VAI) were calculated. Results: A correlation was found in the analysis of LAP index values (OR = 1.017; p = 0.050). The analysis of hormone concentrations showed a correlation between the diagnosed trait and the value of TT (OR = 1.216; p = 0.046) and SHBG (OR = 1.020; p = 0.007). Conclusions: VAI and LAP have been shown to be good indicators for assessing erectile dysfunction in men over 60 years of age.
Healthy Eating and Mortality among Breast Cancer Survivors: A Systematic Review and Meta-Analysis of Cohort Studies
Authors: Lee Eunkyung , Kady Vanessa , Han Eric , Montan Kayla , Normuminova Marjona , Rovito Michael J.
Published: June 2022

This systematic review examined the effect of diet quality, defined as adherence to healthy dietary recommendations, on all-cause and breast cancer-specific mortality. Web of Science, Medline, CINAHL, and PsycINFO databases were searched to identify eligible studies published by May 2021. We used a random-effects model meta-analysis in two different approaches to estimate pooled hazard ratio (HR) and 95% confidence interval (CI) for highest and lowest categories of diet quality: (1) each dietary quality index as the unit of analysis and (2) cohort as the unit of analysis. Heterogeneity was examined using Cochran’s Q test and inconsistency I2 statistics. The risk of bias was assessed by the Newcastle–Ottawa Scale for cohort studies, and the quality of evidence was investigated by the GRADE tool. The analysis included 11 publications from eight cohorts, including data from 27,346 survivors and seven dietary indices. Both approaches yielded a similar effect size, but cohort-based analysis had a wider CI. Pre-diagnosis diet quality was not associated with both outcomes. However, better post-diagnosis diet quality significantly reduced all-cause mortality by 21% (HR = 0.79, 95% CI = 0.70, 0.89, I2 = 16.83%, n = 7) and marginally reduced breast cancer-specific mortality by 15% (HR = 0.85, 95% CI = 0.62, 1.18, I2 = 57.4%, n = 7). Subgroup analysis showed that adhering to the Diet Approaches to Stop Hypertension and Chinese Food Pagoda guidelines could reduce breast cancer-specific mortality. Such reduction could be larger for older people, physically fit individuals, and women with estrogen receptor-positive, progesterone receptor-negative, or human epidermal growth factor receptor 2-positive tumors. The risk of bias in the selected studies was low, and the quality of evidence for the identified associations was low or very low due to imprecision of effect estimation, inconsistent results, and publication bias. More research is needed to precisely estimate the effect of diet quality on mortality. Healthcare providers can encourage breast cancer survivors to comply with healthy dietary recommendations to improve overall health. (Funding: University of Central Florida Office of Undergraduate Research, Registration: PROSPERO-CRD42021260135).
A Latent Profile Analysis of Precarity and Its Associated Outcomes: The Haves and the Have-Nots
Authors: Bazzoli Andrea , Probst Tahira M. , Tomas Jasmina
Published: June 2022

A continuing debate on the nature of precarity surrounds its defining characteristics and identification of what constitutes precarity. While early sociological work argued that people either experience precarity or they do not (i.e., the haves and the have-nots), subsequent researchers have gone to great lengths to argue for a more nuanced approach with multiple distinct classes of precarity. Using cross-lagged data from n = 315 U.S. employees collected during the COVID-19 pandemic, we took a person-centered approach to address this central question and uncover latent subpopulations of precarity. Specifically, we conducted a latent profile analysis of precarity using various objective and subjective indicators including perceptions of job insecurity, financial insecurity, prior unemployment experiences, per capita household income, skill-based underemployment, and time-based underemployment. While we anticipated different profiles based on income- vs. employment-based sources of precarity, the best-fitting solution surprisingly comported with Standing’s proposed two-class model. Moreover, membership in the precarious profile was associated with consistently more adverse subsequent outcomes across work, health, and life domains adding to the validity of the obtained two-profile structure. We discuss these results in light of potential loss spirals that can co-occur with the experience of precarity.
The Effects of School Climate, Parent–Child Closeness, and Peer Relations on the Problematic Internet Use of Chinese Adolescents: Testing the Mediating Role of Self-Esteem and Depression
Authors: Wang Hua
Published: June 2022

Although previous research has investigated the associations among family factors, school factors, peer factors, and problematic Internet use, its causal direction has not been verified, particularly in the Chinese context. Using school-based data, this study aims to explore the possible causal direction among school climate, parent–child closeness, peer relations, and the problematic Internet use of Chinese adolescents. Nine hundred and sixty students in junior and senior high schools participated in a questionnaire survey. The results showed that parent–child closeness, school climate, and peer relations had a significantly direct effect on the problematic Internet use of Chinese adolescents. Meanwhile, the effects of parent–child closeness, school climate, and peer relations on problematic Internet use were mediated by self-esteem and depression. Implications are also discussed to prevent the problematic Internet use of adolescents.
Recent Advances in Ionic Liquids and Ionic Liquid-Functionalized Graphene: Catalytic Application and Environmental Remediation
Authors: Zhou Han , Bai Shaoyuan , Zhang Yanan , Xu Dandan , Wang Mei
Published: June 2022

Applications of ionic liquids (ILs) for the modification physicochemical properties of porous materials have been extensively studied with respect to various applications based on the understanding and development of properties of ILs. In this review, IL–graphene composites are discussed and provided a perspective of composites of IL. IL has been used as a medium to improve the dispersibility of graphene, and the resulting composite material shows excellent performance in gas separation and catalysis during environmental treatment. The applications of ILs and IL–functionalized graphene are discussed in detail with the actual environmental issues, and the main challenges and opportunities for possible future applications are summarized.
Skin Toxicity of Selected Hair Cosmetic Ingredients: A Review Focusing on Hairdressers
Authors: Symanzik Cara , Weinert Patricia , Babić Željka , Hallmann Sarah , Havmose Martin Stibius , Johansen Jeanne Duus , Kezic Sanja , Macan Marija , Macan Jelena , Strahwald Julia , Turk Rajka , van der Molen Henk F. , John Swen Malte , Uter Wolfgang
Published: June 2022

The safety assessment of cosmetics considers the exposure of a ‘common consumer’, not the occupational exposure of hairdressers. This review aims to compile and appraise evidence regarding the skin toxicity of cysteamine hydrochloride (cysteamine HCl; CAS no. 156-57-0), polyvinylpyrrolidone (PVP; CAS no. 9003-39-8), PVP copolymers (CAS no. 28211-18-9), sodium laureth sulfate (SLES; CAS no. 9004-82-4), cocamide diethanolamine (cocamide DEA; CAS no. 68603-42-9), and cocamidopropyl betaine (CAPB; CAS no. 61789-40-0). A total of 298 articles were identified, of which 70 were included. Meta-analysis revealed that hairdressers have a 1.7-fold increased risk of developing a contact allergy to CAPB compared to controls who are not hairdressers. Hairdressers might have a higher risk of acquiring quantum sensitization against cysteamine HCl compared to a consumer because of their job responsibilities. Regarding cocamide DEA, the irritant potential of this surfactant should not be overlooked. Original articles for PVP, PVP copolymers, and SLES are lacking. This systematic review indicates that the current standards do not effectively address the occupational risks associated with hairdressers’ usage of hair cosmetics. The considerable irritant and/or allergenic potential of substances used in hair cosmetics should prompt a reassessment of current risk assessment practices.
Generalized and Specific Problematic Internet Use in Central Siberia Adolescents: A School-Based Study of Prevalence, Age–Sex Depending Content Structure, and Comorbidity with Psychosocial Problems
Authors: Tereshchenko Sergey , Kasparov Edward , Semenova Nadezhda , Shubina Margarita , Gorbacheva Nina , Novitckii Ivan , Moskalenko Olga , Lapteva Ludmila
Published: June 2022

We aimed to assess the prevalence, content structure and, psychological comorbidity of PIU in Russian adolescents. In addition, the design of our research provided an opportunity to compare demographic and psychological patterns of different forms of PIU: generalized (PIUgen) and specific problematic video game use (PUgame), as well as problematic social media use (PUsocial). Methods: This is a one-stage cross-sectional observational study of school sampling in three major Siberian cities. A total of 4514 schoolchildren aged 12–18 (mean age 14.52 ± 1.52 years) were surveyed. The Chen Internet Addiction Scale, the Game Addiction Scale for Adolescents, and the Social Media Disorder Scale were used to identify PIU and its types. Results: The prevalence of PIUgen among adolescents in Central Siberia was 7.2%; the prevalence of PUgame was 10.4%; the prevalence of PUsocial was 8.0%. The results of structural equation modelling, as well as the correlation analysis data, suggest two possible patterns of psychosocial problems with PIU—the first one is characteristic of both PIUgen and PUsocial. The second one—which is significantly different—is characteristic of PUgame. Conclusions: Urban adolescents in Central Siberia do not differ significantly from their Asian and European peers. Our findings support the concept of rejecting the term “generalized PIU” as a single psychological construct.
The Management of HIV Care Services in Central and Eastern Europe: Data from the Euroguidelines in Central and Eastern Europe Network Group
Authors: Skrzat-Klapaczyńska Agata , Kowalska Justyna D. , Afonina Larisa , Antonyak Svitlana , Balayan Tatevik , Begovac Josip , Bursa Dominik , Dragovic Gordana , Gokengin Deniz , Harxhi Arjan , Jilich David , Kase Kerstin , Lakatos Botond , Mardarescu Mariana , Matulionyte Raimonda , Oprea Cristiana , Panteleev Aleksandr , Papadopoulos Antonios , Sojak Lubomir , Tomazic Janez , Vassilenko Anna , Vasylyev Marta , Verhaz Antonija , Yancheva Nina , Yurin Oleg , Horban Andrzej
Published: June 2022

Introduction: The COVID-19 pandemic has been challenging time for medical care, especially in the field of infectious diseases (ID), but it has also provided an opportunity to introduce new solutions in HIV management. Here, we investigated the changes in HIV service provision across Central and Eastern European (CEE) countries before and after the COVID-19 outbreak. Methods: The Euroguidelines in Central and Eastern Europe Network Group consists of experts in the field of ID from 24 countries within the CEE region. Between 11 September and 29 September 2021, the group produced an on-line survey, consisting of 32 questions on models of care among HIV clinics before and after the SARS-CoV-2 outbreak. Results: Twenty-three HIV centers from 19 countries (79.2% of all countries invited) participated in the survey. In 69.5% of the countries, there were more than four HIV centers, in three countries there were four centers (21%), and in four countries there was only one HIV center in each country. HIV care was based in ID hospitals plus out-patient clinics (52%), was centralized in big cities (52%), and was publicly financed (96%). Integrated services were available in 21 clinics (91%) with access to specialists other than ID, including psychologists in 71.5% of the centers, psychiatrists in 43%, gynecologists in 47.5%, dermatologists in 52.5%, and social workers in 62% of all clinics. Patient-centered care was provided in 17 centers (74%), allowing consultations and tests to be planned for the same day. Telehealth tools were used in 11 centers (47%) before the COVID-19 pandemic outbreak, and in 18 (78%) after (p = 0.36), but were represented mostly by consultations over the telephone or via e-mail. After the COVID-19 outbreak, telehealth was introduced as a new medical tool in nine centers (39%). In five centers (28%), no new services or tools were introduced. Conclusions: As a consequence of the COVID-19 pandemic, tools such as telehealth have become popularized in CEE countries, challenging the traditional approach to HIV care. These implications need to be further evaluated in order to ascertain the best adaptations, especially for HIV medicine.
Can the Policy of National Urban Agglomeration Improve Economic and Environmental Gains? Evidence from Quasi-Natural Experiments with 280 Cities in China
Authors: Kong Fanchao , Zhang Hongkai , Meng Xiangyan , Li Shuai , Liu Jia
Published: June 2022

Urban agglomerations are an important symbol in the development of modernization. In this paper, we utilize the National Urban Agglomeration (NUA) policy as a quasi-natural experiment in the Chinese context. Adopting data from 280 cities from 2005 to 2019 as research samples, we use difference-in-differences (DID) and spatial difference-in-differences models (SDID) to examine the effect and mechanism of the implementation of the NUA policy on economic development and environmental pollution in China. The result shows that the NUA policy can achieve urban economic and environmental gains, which still holds after the robustness test. The heterogeneity analysis showed that the effects of the NUA policy are more evident in large and medium-sized cities. The curbing effect of the NUA policy on pollution emissions is apparent in the eastern region. Considering spatial heterogeneity, the expected economic and environmental benefits of the NUA policy are partially borne out. In addition to the green technology innovation, the NUA policy also influences regional economic development and environmental pollution through industrial agglomeration and the upgrading of industrial structures, respectively. It is essential to strengthen regional cooperation and establish the development concept of community interests between cities.
Vulnerability Assessment of Farmland Groundwater Pollution around Traditional Industrial Parks Based on the Improved DRASTIC Model—A Case Study in Shifang City, Sichuan Province, China
Authors: Zhang Yibo , Qin Hao , An Guanping , Huang Tao
Published: June 2022

In this study, an improved DRASTIC model, including the DRASTIC-LTPD model and the AHP-DRASTIC-LTPD model, with the addition of four extra evaluation factors, including land use type (L), aquifer thickness (T’), aquifer potential (P) and pollution source distance (D’), was constructed and compared to assess the groundwater vulnerability around farmland area in Shuangsheng Industrial Park, Sichuan Province, China. From the vulnerability grading charts of the traditional DRASTIC model, the improved DRASTIC-LTPD model and the AHP-DRASTIC-LTPD model, it showed that the vulnerability presented a lower level in the western and eastern farmland areas, whereas a higher level was in the central industrial park area. This result was consistent with the actual situation where groundwater recharge by rivers, regional land use, and human activities were more active in the middle in these areas. Nevertheless, the area at the same level of vulnerability varied greatly from model to model. The vulnerability index V-level region ratio calculated by the AHP-DRASTIC-LTPD model was 0, indicating that the distribution of vulnerability was smoother without the appearance of extremely good or poor conditions. From the present study, it was revealed that the AHP-DRASTIC-LTPD model could effectively reflect the impact of human activities and dilution on groundwater vulnerability. The adopted AHP method was also of high accuracy to empower the evaluation index leading to a more reliable evaluation results of regional groundwater vulnerability in comparison with the other two models. Therefore, this research could be employed as a reference for the evaluation of groundwater pollution around other similar unplanned industrial parks.