bluuebunny/crossref_metadata_2025 huggingface dataset:
A Clinical Risk Score to Predict the Critical Illness in Respiratory Syncytial Virus Co- detected With Streptococcus Pneumoniae Hospitalized Children
Authors: Li Lu , Huang Xiaohan , Xu Ximing , Liu Enmei , Deng Yu
Published: December 2024

Purpose To develop and validate a clinical score at hospital admission for predicting which patients will develop critical illness.
Methods A retrospective study was conducted in the Children’s Hospital of Chongqing Medical University from January 2012 to December 2021. Epidemiological, clinical, laboratory, and imaging variables ascertained at hospital admission were screened using Least Absolute Shrinkage and Selection Operator and logistic regression to construct a predictive risk score. Accuracy of the score was measured by the area under the receiver operating characteristic curve (AUC). Data from our hospital and another hospital were used to validate the score.
Results The study included 1516 patients totally, including training cohort 1039 patients，validation cohort 477 patients, and external cohort 122 patients. From 35 potential predictors, 11 variables were independent predictive factors and were included in the risk score: neonate hospitalization，chronic pulmonary disease，congenital heart disease，immune deficiency disease，anhelation，disorders of consciousness，assisted respiration，lymph decreased，RBC decreased，CRP increased，pulmonary atelectasis. The mean AUC in the training cohort was 0.853, the AUC in the validation cohort was 0.848，and the external cohort was 0.967.
Conclusion In this study, the risk score based on characteristics of RSV-infected patients co-detected with S.pn at the time of admission to the hospital was developed that may help predict a patient’s risk of developing critical illness.
Computed Tomography (CT)-Guided Medical Sodium Hyaluronate Gel for Paravascular Microwave Ablation of Rabbit Liver Large Vessels
Authors: Li Xiaolan , He Shan , Hui Yani , Li Bing , Du Yong
Published: December 2024

Objective The objective of this study is to investigate the effect of medical sodium hyaluronate gel on large blood vessels during microwave ablation (MWA) of rabbit hepatic paravalves.
Methods Forty-eight New Zealand large white rabbits were selected and randomly divided into a sodium hyaluronate gel MWA immediate group (group A, n = 12), sodium hyaluronate gel MWA one-week postoperative group (group B, n = 12), conventional MWA immediate group (group C, n = 12), and conventional MWA one-week postoperative group (group D, n = 12). Groups A and B were both injected with 1 mL of sodium hyaluronate gel and then underwent MWA, and groups C and D underwent direct MWA. Histopathological examinations were performed to observe the damage of large vessels within the ablation area in every group.
Results The difference in the degree of damage to large vessels after MWA in the four groups was statistically significant (P<0.05). The rates of vascular injury after MWA in groups A–D were 0.00%, 58.3%, 100.0%, and 100.0%, respectively . During MWA and postoperative follow-up in the four groups, one rabbit in group D died, while another developed fatty liver, cirrhosis, and ascites in group B. The maximum diameters of the ablation zones in groups B and D were 2.86±0.48 cm and 2.58±0.50 cm, respectively, one week after surgery and 2.87±0.49cm and 2.58±0.50 cm, respectively, immediately after surgery, exhibiting statistically significant differences (P<0.001).
Conclusion Medical sodium hyaluronate gel has a protective effect on large vessels during hepatic paravascular MWA.
Exploring the key role of neuroinflammation in the formation of delayed encephalopathy after acute carbon monoxide poisoning based on multi-omics and snRNA-seq
Authors: Li Jinlan , Li Jun , Fu Junming , Huang Chuying , Lv Wenqi , Zhang Chunlong , Tian Tianjie , Liu Qunhui , Yang Shijun , Tan Yong , Sun Guogen , Xiang Ying , Huang Guoquan , Wang Ning
Published: December 2024

Despite the high incidence and disability rates of delayed encephalopathy after acute carbon monoxide poisoning (DEACMP), its pathogenesis remains enigmatic, and specific predictive markers are lacking. This study aimed to elucidate the molecular underpinnings and identify predictive biomarkers of DEACMP through multi-omics and single-nucleus RNA sequencing (snRNA-seq). We collected clinical data and blood samples from 105 participants, including healthy controls (HCs), acute carbon monoxide poisoning patients (ACOP), and those receiving comprehensive treatment for ACOP (ACOP-CT). Untargeted metabolomics sequencing was employed to profile serum metabolites across these groups. Additionally, individuals from the HCs, ACOP, non-delayed encephalopathy after ACOP (DEACMP-N), and DEACMP groups (n = 3 each) were randomly selected for transcriptome sequencing to identify potential predictive targets and pivotal signaling pathways associated with DEACMP. Furthermore, we established severe DEACMP and Control Sprague-Dawley rat models and assessed neurocognitive function using the Morris water maze on the 28th day. Subsequently, three rats from the Control, DEACMP, and DEACMP + Dexamethasone + Selenomethionine groups were selected for snRNA-seq to analyze hippocampal single-cell transcriptional profiles. Immunofluorescence multiplexing was then performed to validate the identified predictive targets. Our analysis of clinical data from 105 participants highlights the pivotal role of inflammation in influencing the prognosis of carbon monoxide poisoning. Metabolomics analysis identified 19 metabolites that significantly differed between the DEACMP-N and DEACMP groups compared to the ACOP-CT follow-up results. Transcriptomics analysis of 12 participants indicated that DEACMP is primarily associated with six signaling pathways, including lysosome and tuberculosis. Given that microglia are central nervous system immune effectors, our snRNA-seq analysis revealed altered genes expression and signaling pathways in microglia during DEACMP, with KEGG analysis highlighting phagosome, neutrophil extracellular trap formation, lysosome, and tuberculosis as the predominant pathways. Differential gene analysis from transcriptome and snRNA-seq identified 28 genes differentially expressed in DEACMP. The STRING database and immunomultiplexing confirmed the pivotal role of the IFNGR1/STAT1/CTSS axis in DEACMP. This study provides a comprehensive overview of serum metabolite expression, differential genes expression, and signaling pathways in DEACMP patients, offering a robust theoretical foundation for understanding the pathogenesis for DEACMP.
Preoperative CT-based radiomics combined with AFP, PIVKA-II and other laboratory tests can be used to predict the pathological grade of hepatocellular carcinoma
Authors: Wu Meng , Yu Haijia , Pang Siwen , Liu Aie , Liu Jianhua
Published: December 2024

Background To investigate how effectively clinical features and CT-based radiomics predict the pathological grade of hepatocellular carcinoma（HCC）.
Methods We retrospectively analyzed 108 patients diagnosed with hepatocellular carcinoma who underwent pathological examination between May 2020 and May 2024 at the Second Hospital of Jilin University. All patients underwent laboratory tests and contrast-enhanced computed tomography（CECT）scanning of the liver within one month prior to pathological examination. In the first step, we analyzed laboratory tests such as Alpha fetoprotein (AFP) and des-γ-carboxy prothrombin (PIVKA-II) to derive risk factors associated with pathological grading of HCC, and then built and evaluated the performance of the clinical model. After that, we imported the arterial-phase and venous-phase images of the CECT into the uAI Research Portal research platform for ‘one-stop’ processing, which included semi-automatic ROI outlining, feature extraction, dimensionality reduction, model construction and evaluation. To evaluate the model's diagnostic effectiveness, receiver operating characteristic (ROC) curves were produced, and the related accuracy, sensitivity, specificity, and area under the curve (AUC) were computed. The models were compared using the Delong test, and the clinical value of the predictive model was assessed by plotting calibration curves and decision curve analysis (DCA) to quantify the agreement between the model and the actual outcomes.
Results Poorly differentiated hepatocellular carcinoma (pHCC) is associated with risk variables such as HCVAb, PIVKA-Ⅱ, and sex. In the training and validation cohorts, the clinical model's AUC values were 0.719 and 0.692, respectively; the AP model's were 0.843 and 0.773; the VP model's were 0.806 and 0.804; the AP + VP model's AUC values were 0.953 and 0.844 ; and the AP+VP+clinical model's were 0.926 (95% CI: 0.88-0.995) and 0.863 (95% CI: 0.711-1). The DCA curves show that the overall net benefit of the AP + VP + clinical model is higher than that of the other models and that it has the best diagnostic results.
Conclusions CT-based radiomics modeling combined with clinical features (sex) and laboratory tests (e.g., AFP and PIVKA-II, etc.) can reliably predict the pathologic grading of HCC patients prior to surgery.
Identification and validation of an explainable transformer-based model for predicting the prognosis of patients with Non-small cell lung cancer
Authors: Zhang Peng , Ren Ruizi , Ren Zhanliang , Wang Bo , Chen Hang , Wang Yanqiu , Liu Yanzhen , Qi Ruihua , Zhang Yong , Liu Yunhao
Published: December 2024

Background
Currently, there is a lack of practical and explainable prognostic models for NSCLC in clinical settings. This study aims to construct an explainable prognostic model for NSCLC using the Transformer framework in deep learning.
Methods
119751 patients from the Surveillance, Epidemiology and End Results (SEER) database were used to train a Transformer-based model to predict the overall survival (OS) at 12, 24, and 60 months. Additionally, the SHapley Additive exPlanation (SHAP) method was employed to interpret the constructed model, show casing the importance of various clinical indicators on patient survival at different time points.
Result
The time dependent AUC values of 12 months, 24 months and 60 months were 0.853, 0.860 and 0.871 i Currently, there is a lack of practical and explainable prognostic models for NSCLC in clinical settings. This study aims to construct an explainable prognostic model for NSCLC using the Transformer framework in deep learning.
n the training cohort, 0.863, 0.881, 0.899 in the validation cohort, and 0.850, 0.851 and 0.869 in the testing cohort, respectively. Moreover, a risk scoring system based on the Kaplan Meier (KM) survival curves can accurately divide patients into three risk groups. Ultimately, the explainable model demonstrates the differences in the importance of various patient indicators for short-term and long-term survival.
Conclusion
The distant metastasis of tumor has a significant effect on the short-term survival of patients. The effect of surgery on long term survival is more significant than short term survival.
The mitogenome mutation repertoire affects progression of Parkinson´s Disease
Authors: Matos Gustavo Barra , Santos Camille Sena , Sousa Tatiane Piedade , Cavalcante Giovanna Chaves , Silva Caio Santos , Cruz Rebecca Lais Silva , Moura Dafne Dalledone , Ribeiro-dos-Santos Andrea , Lobato Bruno Lopes Santos , Araújo Gilderlanio Santana
Published: December 2024

Background
Mitochondrial genome variation is a risk factor for Parkinson's disease, but its role in levodopa-induced dyskinesia remains incompletely understood. This study investigates the mitochondrial mutation repertoire as potential biomarkers for levodopa-induced dyskinesia in Parkinson's disease patients.
Methods
We analyzed the mitogenome by next generation sequencing data from 42 controls and 45 people with Parkinson's (25 without dyskinesia and 20 with dyskinesia). The mtDNA-server2 workflow were applied for variant calling analysis.
Results
Transition and transversion rates vary during disease progression, especially in patients without levodopa-induced dyskinesia. Although the occurrence of these mutations does not follow a linear pattern, transitions modestly increase with age. Specific coding regions (MT-CO1, MT-CO3, MT-ND4, MT-ND5) and the regulatory region (MT-RNR2) showed enrichment of transitions and transversions in patients without dyskinesia.
Conclusion
The study highlights dynamic shifts in the mitochondrial mutation repertoire with clinical implications in underrepresented populations, emphasizing the importance of considering genetic characteristics in diverse groups.
A specific gene expression program underlies antigen archiving by lymphatic endothelial cells in mammalian lymph nodes
Authors: Tamburini Beth , Sheridan Ryan , Doan Thu , Lucas Cormac , Forward Tadg , Fleming Ira , Uecker-Martin Aspen , Morrison Thomas , Hesselberth Jay
Published: December 2024

Lymph node (LN) lymphatic endothelial cells (LEC) actively acquire and archive foreign antigens. Here, we address questions of how LECs achieve durable antigen archiving and whether LECs with high levels of antigen express unique transcriptional programs. We used single cell sequencing in dissociated LN tissue and spatial transcriptomics to quantify antigen levels in LEC subsets and dendritic cell populations at multiple time points after immunization and determined that ceiling and floor LECs archive antigen for the longest duration. We identify, using spatial transcriptomics, antigen positive LEC-dendritic cell interactions. Using a prime-boost strategy we find increased antigen levels within LECs after a second immunization demonstrating that LEC antigen acquisition and archiving capacity can be improved over multiple exposures. Using machine learning we defined a unique transcriptional program within archiving LECs that predicted LEC archiving capacity in mouse and human independent data sets. We validated this modeling, showing we could predict lower levels of LEC antigen archiving in chikungunya virus-infected mice and demonstrated in vivo the accuracy of our prediction. Collectively, our findings establish unique properties of LECs and a defining transcriptional program for antigen archiving that can predict antigen archiving capacity in different disease states and organisms.
Linking Changes in Sulcal Morphology to Cognitive Development from Childhood to Adolescence
Authors: Li Shuyu , Shan Yijin , Qiao Huiting , He Yirong , Chu Lei , Zeng Debin , Zhao Tengda , Liao Xuhong , Chen Xiaodan , Xia Yunman , Lei Tianyuan , Sun Lianglong , Men Weiwei , Wang Yanpei , Wang Daoyang , Hu Mingming , Pan Zhiying , Tan Shuping , Gao Jia-Hong , Qin Shaozheng , Tao Sha , Dong Qi , He Yong
Published: December 2024

Throughout childhood and adolescence, the development of motor skills and cognitive functions is accompanied by concurrent changes in the morphology of cortical sulci. In this study, we analyzed structural MRI (sMRI) data from a longitudinal cohort of 312 children (145 females) aged 6 to 14 years to reconstruct and label the brain's sulci, followed by mixed-effects modeling to assess age-related morphological changes. We further investigated the relationship between morphological changes and cognitive development during this period via the least absolute shrinkage and selection operator (LASSO) method. Our results revealed a significant increase in the width of secondary/tertiary sulci compared with primary sulci. An increased width of the secondary intermediate ramus of the intraparietal sulcus in children predicted improvements in Attention Network Test performance, whereas an increased width of the posterior intralingual sulcus was most strongly associated with improvements in working memory performance. Through gene enrichment analysis, we discovered that the age-related changes in sulcal morphology are linked to underlying biological processes, including synaptic reorganization and myelination. This study enhances our understanding of the relationship between sulcal morphology and cognitive function, highlighting mechanisms that may influence brain development from childhood to adolescence.
Damm, Steffen/Jendis, Sirkka/Müller- Wirth, Moritz/Siebenhaar, Klaus (2012). Das kuratierte Ich. Jugendkulturen als Medienkulturen im 21. Jahrhundert. Schriftreihe Mobiles Breitband & Digitale Öffentlichkeiten, Bd. 4. Berlin: Siebenhaar Verlag.
Authors: Merz Redaktion
Published: December 2024

Jugendkulturen verändern und entwickeln sich immer weiter über die Zeit. Durch die zentrale Stellung der Medien im Leben von Jugendlichen kann man die Überlegung anstellen, Jugendkulturen auf die Medien zu übertragen und in diesem Kontext möglicherweise von Medienkulturen zu sprechen. Hier knüpfen Steffen Damm, Sirkka Jendis, Moritz Müller-Wirth und Klaus Siebenhaar mit ihrem Buch Das kuratierte Ich – Jugendkulturen als Medienkulturen im 21. Jahrhundert an. Dieses gliedert sich in vier Teile. Zu Beginn geht es um eine Bestandsaufnahme. Wie sieht es in der Medienforschung heute aus? Wie sehen die kulturellen Dimensionen von medialen Transformationsprozessen aus? An dieser Stelle wird kurz auf den Begriff des „kuratierten Ich“ eingegangen: Es handelt sich um die Selbstdarstellung in den Medien, die in einem Zeitverlauf verfolgt werden kann.
Daran anschließend wagen die Autorin und die Autoren einen Blick auf historisch-aktuelle Befunde. Hierfür wird das 20. Jahrhundert im Kontext von Jugendkulturen ins Auge gefasst. Mediennutzung und Social Media werden ebenso thematisiert und ausdifferenziert betrachtet. Der dritte Teil behandelt das „kuratierte Ich“ in sozialen Netzwerken und damit zusammenhängenden Entwicklungen. Dabei geht es unter anderem um das Zusammenspiel von Jugend, Medien und Kultur sowie um die Wege zum „kuratierten Ich“. Auf diese Weise führen Damm, Jendis, Müller-Wirth und Siebenhaar auf 13 Thesen bezüglich Jugendkulturen als Medienkulturen hin.
Im letzten Teil des Buches befindet sich die Dokumentation der Online-Umfrage zum Thema. Von Interesse ist diese Monografie für Medienpädagoginnen und -pädagogen sowie für Sozialpädagoginnen und -pädagogen, die sich speziell mit dem Bereich Jugend in Theorie und Praxis beschäftigen. cp
Hartmann, Simon/Purz, Dirk (2018). Unterrichten in der digitalen Welt.Göttingen: Vandenhoeck & Ruprecht. 166 S., 20 €.
Authors: Müller Antje
Published: December 2024

Unterrichten in einer digitali­sierten Welt mit zahlreichen Tools und technischen Lösun­gen, die das unabhängige Ler­nen zu ermöglichen und die Wissensbereitstellung zu über­nehmen scheinen, wirf zuneh­mend Fragen um die Rollen von Lehrenden und Schülerin­nen wie Schüler auf. Ist der klassische Lehrkörper obsolet, lösen digitalisierte Lehrmetho­den und Lernmedien den klassi­schen Unterricht ab? Hartmann und Purz stellen sich in ihrem Band Unterrichten in der digita­len Welt den Herausforderun­gen und Chancen eines ‚guten‘ digitalen Unterrichts und setzen sich dabei nicht nur mit verän­derten Kompetenzen pädago­gischer Fachkräfte und Schüle­rinnen wie Schüler auseinander, sondern liefern ebenso metho­dische Impulse und praktische Tipps aus dem Spektrum der im eigenen Unterricht gewonne­nen Erfahrungen und erprobten Tools. Mit dem Ziel, die eige­ne Rolle samt Arbeitsbereich zu reflektieren, werden pädagogische Fachkräfte und ange­hende Lehrende zunächst über traditionelle Lerntheorien und Didaktik-Konzepten langsam auf das neue Erfordernis – der Digitalität – vorbereitet.Zum Abbau (letzter) Vorbehalte, geht der Band über zu konkreteren Beispielen eines blended oder flipped classroom, die sich von einem Medieneinsatz um ih­rer Selbstwillen abgrenzen und von einer Notwendigkeit eigens entwickelter digitaler Lehr- und Lernkonzepte überzeugen. Mit kontinuierlicher Hervorhe­bung erforderlicher didaktisch-medialer Kompetenzen sowie Kenntnisse, verknüpft mit Tool- , Software- sowie Projektemp­fehlungen für eine didaktische Aufbereitung digitaler Lernkon­zepte, werden Lehrende in die konkreten Ausgestaltungsmög­lichkeiten eingeführt. Ganz nah an den Bedürfnissen und päd­agogischem Setting der Ziel­gruppe werden unter anderem interaktive Lernplakate, Multi­user-Mindmaps, Gamification- Tools, Schnittprogramme bis hin zu Open-Source-Lösungen für Schulserver vorgestellt. Dem Medienkompetenz-Aufbau dienend, insbesondere für in­teressierte Lehrende mit eher seltenem Kontakt zu digitalen Methoden, bietet der Band nicht zuletzt auch einen kleinen Ausschnitt eines Wörterbuchs für verwendete Fachbegriffe zur Digitalität.Trotz behutsa­mer Einführung in das Thema und aufschlussreichen Erklärun­gen mit ausführlichen Praxis­vorschlägen bei größtmöglicher Offenheit für eine individuelle Einsetzbarkeit spricht der Band eher Fortgeschrittene im Um­gang mit digitalen Lehr- und Lernmethoden an. Unterrich­ten in der digitalen Welt bietet insgesamt kompakt aufberei­tetes, nützliches und vor al­lem handhabbares Wissen, das zum Weiterdenken anregt. Die wissenschaftlichen Beiträge dieses Bandes bieten - unter Betrachtung der Aktualität und Relevanz der Themen - eine geeignete Grundlage zur Um­setzung medienpädagogischer Methoden.
Zeaiter, Sabrina/Handke, Jürgen (Hrsg.) (2020). Inverted Classroom – Past, Present & Future. Kompetenzorientiertes Lehren und Lernen im 21. Jahrhundert. Tectum. 194 S., 38,00 €.
Authors: Pentz Anna-Clara
Published: December 2024

Längst sind die Digitalisierung und die Einsatzmöglichkeiten digitaler Medien im Unterricht in Schulen und Universitäten angekommen. Auf der achten Fachtagung der Inverted Classroom Konferenz standen wieder die neuesten Entwicklungen der Digitalisierung in Lehre und Lernen im Fokus. Der Tagungsband Inverted Classroom – Past, Present & Future von Sabrina Zeaiter und Jürgen Handke greift die Themen der Tagung auf und liefert Einblicke in die digitale Zukunft der Lehre, wobei bestehende Perspektiven erweitert sowie neue eröffnet werden sollen.
Die Autor*innen stellen aktuelle Themen der digitalen Lehre vor. Dabei sind ‚Blockchain‘, ‚Open Educational Resources‘, ‚MOOCs‘ oder auch ‚Makerspaces‘ die Schlagwörter der letzten Tagung und somit auch die Kernthemen dieses Bands. Einen Einblick in diese Felder liefern einleitend die ‚Keynotes‘ der drei Plenarsprecher. Die Folgebeiträge befassen sich mit den verschiedenen Möglichkeiten der digitalen Lehre – vom Einsatz humanoider Roboter im universitären Umfeld über digitale Unterrichtsformen zur Inklusion bis hin zu konkreten Konzepten zum Einsatz von Inverted Classrooms in den unterschiedlichen Unterrichtsfächern. Die Autor*innen beschreiben das Potenzial und den Mehrwert unterschiedlichster Plattformen und Tools und liefern damit einen Einblick in die vielseitigen Optionen für digitalen Unterricht. Das Buch richtet sich somit an Lehrende und Lerninstitutionen und bietet einen interessanten und spannenden Einblick in und Überblick über Inverted-Classroom-Konzepte.
#14 – Rassismus & Medien Teil 2
Authors: Merz Redaktion , Schnabel Deborah , Seidel Eberhard
Published: December 2024

Auch mit den Gästen dieser Podcast-Folge sprechen wir über die Chancen, die Medien in der antirassistischen Bildungsarbeit bieten. Für Dr. Deborah Schnabel, die Stellvertretende Direktorin der ‚Bildungsstätte Anne Frank‘ sind Soziale Medien längst ein elementares Tool in der Bildungsarbeit (3:15-19:25). Die ‚Bildungsstätte Anne Frank‘ leistet inzwischen neben den klassischen Projekten und Workshops sehr viel politische Bildungsarbeit über diverse Social-Media-Kanäle. Und auch für ‚Schule ohne Rassismus – Schule mit Courage‘ bieten diese Plattformen ganz neue, tolle Möglichkeiten zur Vernetzung der Schulen in diesem Netzwerk gegen Rassismus. Geschäftsführer Eberhard Seidel erzählt (ab Min. 19:35) von den positiven Entwicklungen, dass Rassismus seit den Anfängen des Courage-Netzwerks immer mehr zum Thema geworden ist.
#7 – Eltern & Medien Teil 3
Authors: Struckmeyer Kati , Paus-Hasebrink Ingrid , Beranek Angelika , Wohlfarth Jerome
Published: December 2024

In der siebten Folge ‚mehr merz‘ kommen zwei Professorinnen zum Thema ‚Eltern und Medien‘ zu Wort.
Unsere Chefredakteurin Kati Struckmeyer war mit Professorin Ingrid Paus-Hasebrink im Gespräch (3:55 bis 22:55). Mit ihr unterhält sie sich über ihre zwölfjährige Panel-Studie zur Mediensozialisation benachteiligter Heranwachsender. Professorin Angelika Beranek (Hochschule München, Fakultät Angewandte Sozialwissenschaft) betont im Gespräch mit unserem Redakteur Jerome Wohlfarth (ab Minute 23:00), dass es Aufgabe von Pädagoginnen und Pädagogen gerade beim Thema Medien ist, Übersetzungsarbeit zwischen den Kindern und den Eltern zu leisten. Angehende Pädagog*innen sollten viel intensiver in die Medienbildung einsteigen.
#9 – Eltern & Medien Teil 5
Authors: Merz Redaktion , Wolf Jürgen , Anfang Günther
Published: December 2024

Abschließend zur Themenreihe ‚Eltern und Medien‘ kommen in der neunten Folge zwei Experten aus der Elternarbeit zu Wort. Jürgen Wolf (ab Minute 02:20) ist Leiter der Abteilung Erziehungsberatung des Evangelischen Beratungszentrums München e. V. und mittlerweile spielen Medien in jedem Konflikt zwischen Eltern und Kindern eine Rolle. Er ermutigt Familien, sich über Medienthemen auszutauschen. Mit über 400 Elternabenden ist Medienpädagoge Günther Anfang (ab Minute 23:10), Leiter des MZM – Medienzentrums München des JFF, geschult, wenn es um Tipps für Eltern zum Thema Medien geht. Dennoch betont er, dass es kein Patentrezept in der Medienerziehung gibt.
Buettner, Anke, Ebert, Olivia & Hasselberg, Viola (Hrsg.) (2024). Female Peace Palace. Schreiben, Widerstand und Pazifismus im Krieg. Berlin: Verbrecher. 254 S., 25,00 €.
Authors: Ring Sebastian
Published: December 2024

„Wie geht Frieden?“ ist die erste Frage, die die Herausgeberinnen im Vorwort stellen. Ausgangspunkt der Publikation Female Peace Palace ist das Festival, das vor 16 Monaten durch die Monacensia, Literaturarchiv und literarisches Gedächtnis der Stadt München, sowie die Münchner Kammerspiele und Theater der Stadt veranstaltet wurde. Die Publikation knüpft an die Auseinandersetzungen mit Krieg und den Aktivismus weiblicher Akteur*innen, Gestalter*innen und Kämper*innen für Frieden an. Bezugspunkt ist der Internationale Frauenfriedenskongress, der im Jahr 1915 in Den Haag in den Niederlanden stattfand. Die Fragen nach Gelingensbedingungen von Frieden, nach zu ertragenden Widersprüchen und Visionen für eine bessere Zukunft sind weiterhin aktuell. Sie stellten sich über die Jahrzehnte immer wieder neu und in veränderter Form. Die Publikation zeigt eindrücklich, wie schnell diese Fragen aktualisiert werden: Zwischen dem Festival und Erscheinen des Buches, während der Arbeit an den Texten, ereignete sich am 06./07. Oktober 2023 der Terrorangriff auf Israel. Das Buch versammelt 32 Texte, die das Geschehen des Festivals dokumentieren und um andere Perspektiven erweitern. Künstler*innen und Autor*innen aus verschiedenen Jahrzehnten und Regionen dieser Welt äußern sich darin. Diese teils historischen Texte verweisen nicht nur auf die Vergangenheit, sondern werden in einen besonderen Bezug zu gegenwärtigen Ereignissen gestellt. Das Festival, das im April 2023 Anreize und Zugänge für Reflexion und Diskurse schuf, öffnete auch auf anderen Ebenen Räume dafür: Die Publikation erweitert diese Perspektiven. Die plattformübergreifende Kommunikation vieler Akteur*innen, die über den Hashtag #femalepeacepalace auffindbar sind, trägt ebenfalls dazu bei. Zudem finden sich online ein Podcast sowie die Festivaldokumentation mit Videos und weiteren Texten.
Влияния содержания бересты в пресс-сырье на свойства пластика без связующих на основе березовых опилок
Authors: Артёмов А. В. , Власов Н. Г. , Ершова А. С. , Вураско А. В. , Бурындин В. Г.
Published: December 2024

Были получены образцы пластика без связующего (ПБС) на основе древесного наполнителя с различным соотношением бересты березы. Образцы ПБС прессовались в герметичной пресс-форме под давлением 40 МПа и температуре 180 °С с последующим ее охлаждением без снятия давления до 40 °С. У полученных образцов были исследованы показатели плотности, прочности при изгибе, модуля упругости при изгибе, твердости по Бринеллю, ударной вязкости, водопоглощения и разбухания за 24 ч, биостойкости по отношению к почво-грунту за 90 суток и активному грунту за 105 суток. Также осуществлялась оценка гидрофобности по краевому углу смачивания. На основании полученных результатов испытаний было установлено рациональное соотношение пресс-композиции на основе березовых опилок с добавлением бересты 50%. При данном соотношении достигаются следующие показатели материала: плотность – 909 кг/м3 ; модуль упругости – 1566 МПа; прочность при изгибе – 8,9 МПа; твердость по Бринеллю – 17 МПа; ударная вязкость – 3,818 кДЖ/м2 ; водопоглощение за 24 ч – 32%; разбухание – 7%. Выявлена зависимость роста биостойкости ПБС с увеличением содержания бересты в пресс-материале, что объясняется ее высокой гидрофобностью и антисептическими свойствами.

Samples of plastic without resin (PWR) were produced using a wood filler with varying proportions of birch bark. The PWR samples were pressed in a sealed mold under a pressure of 40 MPa and at a temperature of 180 °C, followed by cooling without pressure release until reaching 40 °C. The resulting samples underwent testing for density, flexural strength, flexural modulus of elasticity, Brinell hardness, impact toughness, water absorption, and swelling after 24 hours. Additionally, biostability was assessed in soil for 90 days and in active soil for 105 days. Hydrophobicity was also evaluated based on the contact angle. Based on the test results, the optimal composition ratio for the press material was determined using birch sawdust with a 50% addition of birch bark. At this ratio, the material exhibited the following properties: density – 909 kg/m³, modulus of elasticity – 1566 MPa, flexural strength – 8.9MPa, Brinell hardness – 17 MPa, impact toughness – 3.818 kJ/m², water absorption in 24 hours – 32%, and swelling – 7%. A correlation was found between increased birch bark content in the press material and enhanced biostability, attributed to its high hydrophobicity and antiseptic properties.
Nutrição + Vida: projeto de extensão em educação alimentar e nutricional para a pessoa idosa
Authors: SCOFANO Hugo Franscisco , GALICIANI Giullia Gabrielli , ROCHA Fabiana Duarte Martins da , PEREIRA Deilan Kilmer Espinosa , MENDES Maria Fernanda Nantes Coelho , MICHELS Ana Keren Oliveira , PEGOLO Giovana Eliza
Published: December 2024

Este trabalho tem como objetivo relatar experiências de Educação Alimentar e Nutricional, realizadas com pessoas idosas, em um Projeto de Extensão. As atividades foram desenvolvidas durante 13 semanas, presencialmente. As principais temáticas abordadas foram: Guia alimentar para a população brasileira; Rotulagem de alimentos; Macro e micronutrientes; Alimentação saudável para a pessoa idosa; Aproveitamento integral dos alimentos e armazenamento; Leite; Alimentos dietéticos. A constatação de ampla diversidade de dúvidas e expressivo interesse sobre hábitos alimentares associados com a saúde pontua a importância de estratégias de Educação Alimentar e Nutricional. Ainda, diante de ambiente acolhedor, de confiança sobre informações técnicas/científicas e o vínculo entre os participantes e a equipe foram essenciais para a adesão ao longo das semanas. Por fim, a Extensão Universitária, além de atender a comunidade, possibilita um processo de aprendizagem ativo aos acadêmicos.
Саркоидоподобное поражение легких у больной множественной миеломой и системным AL-амилоидозом, получавшей даратумумаб (клиническое наблюдение со спонтанной регрессией изменений в легочной ткани после отмены препарата)
Authors: Рехтина Ирина Германовна , Хышова В. А. , Ковригина А. М. , Силаев М. А. , Менделеева Л. П.
Published: December 2024

Sarcoid-like drug reaction is a granulomatous inflammation having clinical and morphological similarity with sarcoidosis and developing as a rule on chemo/immunotherapy. An important characteristic of the drug-induced sarcoid-like reaction consists in its time relationship with a drug assignment and also with a regression upon its withdrawal. Sarcoid-like reactions are known to occur on therapy with immune checkpoint inhibitors, interferons, tumor necrosis factor-alpha antagonists, antiretroviral drugs, BRAF inhibitors, and rituximab. However, no reports have been published on a sarcoid-like reaction associated with the monoclonal anti-CD38 therapy despite a wide experience in their use for treating plasma cell neoplasms. This paper reports the first case of sarcoid-like reaction characterized by pulmonary lesions with confluent large-nodular areas that developed on daratumumab maintenance therapy in a female patient with multiple myeloma and systemic AL amyloidosis. This case report proves the probability of a sarcoid-like reaction on daratumumab therapy. Further studies are necessary to understand the pathogenesis of similar reversible damage.
Субпопуляционный состав лимфоцитов костного мозга при хроническом лимфоцитарном лейкозе у пациентов с различным ответом на противоопухолевое лечение
Authors: Селютина Олеся Николаевна , Златник Е. Ю. , Гуськова Н. К. , Новикова И. А. , Лысенко И. Б. , Сагакянц А. Б. , Пушкарева Т. Ф. , Владимирова Л. Ю.
Published: December 2024

AIM. To analyze the bone marrow lymphocyte subpopulation based on targeted assessment of PD-1, PD-L1, and LAG-3 marker expression in chronic lymphocytic leukemia (CLL) patients with different responses to chemotherapy.
MATERIALS & METHODS. In 33 CLL patients, PD-1, PD-L1, and LAG-3 antigen expression on В-, Т-, and NK-cells of the bone marrow (BM) was analyzed by flow cytofluorometry prior to treatment and after 6 cycles of chemotherapy with rituximab. Patients were aged 58–68 years (median 64 years); there were 14 women and 19 men. Hematologic response was assessed by measurements of minimal residual disease (MRD). On this basis, patients were divided into two groups: group 1 (n = 20) with satisfactory hematologic response (MRD < 1 %) and group 2 (n = 13) with unsatisfactory hematologic response (MRD ≥ 1 %).
RESULTS. Prior to treatment, the count of PD-1-, LAG-3-, CD38-, and ZAP-70-expressing BM tumor B-cells was lower in patients of group 1 than in those of group 2. After treatment, their decrease was more pronounced in group 1. Prior to treatment, patients in group 1 had a higher count of BM T-lymphocytes with CD3+, CD4+, CD8+, CD8+/CD28+, CD8+/CD28–, and CD8+/CD38+ phenotype including PD-1- but neither PD-L1- nor LAG-3-expressing T-cells.
After treatment, increased T-cells with CD3+, CD4+, CD8+, Treg, CD8+/CD28+, and CD8+/CD28– phenotype including PD-1+ T-lymphocytes were detected in both groups but more pronounced in group 2. In this group, CD3+ и CD4+ T-lymphocytes maintained LAG-3 expression. Prior to treatment, all patients showed decreased NK-cells in BM. After treatment, group 1 showed a higher count of NK-cells with CD3–/CD16+/CD56+ and CD3–/CD16+/CD56+/PD-1+ phenotype and a lower count of NK-cells with CD3–/CD16+/CD56+/LAG-3+ phenotype. PD-L1 expression in NK-cells was not detected, whereas in Т- and В-cells it was moderate prior to treatment and was not identified after hematologic response was achieved.
CONCLUSION. The values determined by the targeted assessment of PD-1 and LAG-3 expression in BM В-, Т-, and NK-cells prior to chemotherapy may well be used in clinical practice as additional prognostic factors in CLL. PD-1 and LAG-3 overexpression in Т-lymphocytes and NK-cells in CLL patients with MRD-positive status after chemotherapy can be regarded as evidence of the functional deficiency of these cells.
Japanese Dragon from Paris Collection in Russian Art of Coloured Stone Cutting Art Nouveau Period
Authors:   Ural Federal University named after the first President of Russia B. N. Yeltsin, Vinokurov Sergei Ye. ,   Ekaterinburg Museum of Fine Arts, Budrina Ludmila A. ,   Ural Federal University named after the first President of Russia B. N. Yeltsin
Published: December 2024

The art of Far East countries, namely China and Japan, was an important source for the forms and features of Art Nouveau. However, original works were not the only sources of inspiration. Vivid images of mythical animals, such as two impressive forms of Japanese dragons, penetrated the practices of European craftsmen. This article follows the route of a specific form, and examines the nature of its interpretations, using the example of two stone-cut works by Russian Imperial Lapidary Factories (Peterhof and Ekaterinburg ones). The starting point for these works was an illustration representing a Japanese bronze vase from the Henri Cernuschi collection, published in a French magazine. The discovery and study of this case has provided the exact details to support the general idea about the ways of cross-cultural exchange of Eurasian art at the turn of the 19th and 20th centuries. The article provides a detailed analysis of the decorative elements of a Japanese bronze vase interpreted by Russian stonecutters, and also reveals the features of its implementation in new material. A conclusion is drawn about on the one hand, the discrepancy between the products in question and the main assortment of imperial lapidary factories of the Peterhof and Ekaterinburg. On the other hand, these examples are a convincing illustration of the searches in the Russian art industry of the last third of the 19th century.
Percepções e Práticas sobre as Políticas Públicas para as Juventudes em Sergipe
Authors: Marcon Frank Nilton
Published: December 2024

Neste artigo, analisamos as percepções e práticas das políticas públicas para juventudes em Sergipe, nos últimos dez anos, considerando o seu desenvolvimento no estado e nos municípios, buscando compreender o processo de constituição destas políticas, seus avanços, efeitos e percalços, principalmente observando a participação dos jovens. Em um primeiro momento, circunscrevemos o contexto das políticas no País, delimitamos alguns conceitos e a seguir apresentamos dados empíricos da pesquisa que realizamos com documentos, com as redes sociais de instituições representantes das juventudes, com entrevistas de coordenadores e representantes das juventudes nos conselhos, e a observação direta. Ao fim, tecemos considerações sobre as experiências de institucionalização destas políticas e suas condições de adequação com relação a dinamização da participação, do protagonismo e da construção da autonomia entre os jovens.
FAMILIA COMPOSITAE, TRIBU EUPATORIEAE III: SUBTRIBUS MIKANIINAE Y PRAXELINAE
Authors: Redonda-Martínez Rosario
Published: December 2024

La clave para las subtribus presentes en el área de estudio fue publicada en el fascículo 234 de esta serie. Mikaniinae es una de las 20 subtribus de Eupatorieae, que se diferencia de las demás por su hábito trepador, además de presentar cabezuelas con cuatro filarios uniseriados, cuatro flores y anteras exertas. La subtribu incluye un género y ca. 430 especies en el mundo; en México se registran 18, cuatro de ellas son endémicas, siete tienen amplia distribución y las restantes se comparten con Norte y Centroamérica. En el área de estudio se encuentran dos especies
An Ecological Momentary Assessment Approach of Environmental Triggers in the Role of Daily Affect, Rumination, and Movement Patterns in Early Alcohol Use Among Healthy Adolescents: Exploratory Study (Preprint)
Authors: Prignitz Maren , Guldner Stella , Lehmler Stephan Johann , Aggensteiner Pascal-M , Nees Frauke ,   IMAC-Mind Consortium
Published: December 2024

BACKGROUND

Adolescence is a period characterized by an increased susceptibility to developing risky alcohol consumption habits. This susceptibility can be influenced by social and situational factors encountered in daily life, which, in conjunction with emotions and thoughts, contribute to behavioral patterns related to alcohol use even in the early stages of alcohol experimentation, when initial experiences with alcohol are formed, and regular consumption is still evolving.

OBJECTIVE

This study aimed to examine the association between detailed behavioral and movement patterns, along with emotional and cognitive factors, and the early onset of alcohol use in the everyday lives of adolescents.

METHODS

A total of 65 healthy adolescents (33 male, twenty-nine 14-year-olds, and thirty-six 16-year-olds) underwent mobile-based ecological momentary assessments on alcohol (once a day at 9 AM, assessing alcohol use the day before), positive and negative affect, craving, rumination, and social context (6 prompts/day at 9 AM, 11 AM, 2 PM, 4 PM, 6 PM and 8 PM), type of day (weekdays or weekends, with weekend including Fridays, Saturdays, and Sundays), and using geospatial measures (specifically roaming entropy and number and type of trigger points for alcohol use met) over 14 days. After adjusting for a compliance rate of at least 50%, 52 participants (26 male and twenty-four 14-year-olds) were included in the analyses.

RESULTS

Generalized linear multilevel models revealed that higher positive affect (b=0.685, P=.007), higher rumination (b=0.586, P=.02), and a larger movement radius (roaming entropy) (b=8.126, P=.02) were positively associated with alcohol use on the same day. However, social context (b=–0.076, P=.90), negative affect (b=–0.077, P=.80), or potential trigger points (all P>.05) did not show significant associations. Alcohol use varied depending on the type of day, with more alcohol use on weekends (b=1.082, P<.001) and age (t50=–2.910, P=.005), with 16-year-olds (mean 1.61, SD 1.66) reporting more days of alcohol consumption than 14-year-olds (mean 0.548, SD 0.72).

CONCLUSIONS

Our findings support previously identified factors as significant contributors to very early and low levels of alcohol consumption through fine-grained analysis of daily behaviors. These factors include positive affect, rumination, weekend days, and age. In addition, we emphasize that exploratory environmental movement behavior (roaming entropy) is also significantly associated with adolescent alcohol use, highlighting its importance as an additional factor.

CLINICALTRIAL
РАЗЪЕМЫ USB TYPE-C
Authors: Андриянова М.
Published: December 2024

Разъем USB Type-C представляет собой один из самых современных
интерфейсов для подключения различных приборов. Он был разработан
как универсальное решение для питания, передачи данных и интеграции
периферийных устройств. В статье представлено описание основных
характеристик и спецификаций разъемов USB Type-C от компании
XKB Connection, лидера в области производства широкого спектра
соединителей, тактовых кнопок и других компонентов. Официальным
дистрибьютером XKB Connection является Aurora Evernet Components.
espacio del mal en Estrella distante, de Roberto Bolaño
Authors: Maureira Roldán Diego
Published: December 2024

Este artículo tiene por objeto de estudio la novela de Roberto Bolaño Estrella distante, y propone una lectura interesada en la relación entre las representaciones del mal y la configuración de los espacios en la novela para plantear una discusión en torno a la espacialización del mal. En primera instancia, trataremos de aproximarnos a qué entendemos por el mal en la literatura de Bolaño, reflexionando a partir de discursos literarios, psicoanalíticos y filosóficos. Luego, aproximaremos una definición sobre los espacios en la narración para establecer una relación entre el mal y el espacio en la novela. Esta propuesta de lectura busca señalar que en la constitución de los espacios narrados se percibe la ubicuidad del mal, un mal que pareciera colmar todos los espacios, pero que nunca es concretamente distinguible o localizable. Además, dicha propuesta busca contribuir a renovar miradas sobre las obras de Bolaño e implica directamente complejizar los espacios de la violencia como una propuesta de su obra, pues el espacio no es mero ornamento o tela de fondo de la obra narrativa: más bien es un elemento fundamental de la diégesis, pues comprende las potencias y confrontaciones distinguibles en la narración, que nos pueden ayudar a percibir el recorrido que realiza el mal a través del espacio de la narración.
DOR CRÔNICA E TCC: Intervenção grupal de psicoeducação em reabilitação
Authors: Oliveira Charles Henrique Andrade de
Published: December 2024

CP considered a challenge for the public health system. It includes biopsychosocial factors, leads to resistance and non-adherence to treatments. Studies with scientific evidence of greater effectiveness are based on psychoeducation based on Cognitive Behavioral Therapy (CBT). This article presents a proposal for group intervention formulated through a construct, with a methodological basis in the integrative review, articulating different scientific articles found in the Scielo, Lilacs and Google Scholar databases, between the years 2020 and 2024. The intervention considers concepts, origin, classification, processes, benefits and practices already carried out, and their applicability in CER-IV. It includes multi-professional exchange, promoting a range of strategies for empowering individuals and their active participation in their rehabilitation process. Articulated and dynamic therapeutic behaviors, with team involvement, giving users a leading role promote more effective results.
Infinite quantum signal processing
Authors: Dong Yulong , Lin Lin , Ni Hongkang , Wang Jiasu
Published: December 2024

Quantum signal processing (QSP) represents a real scalar polynomial of degree d using a product of unitary matrices of size 2×2, parameterized by (d+1) real numbers called the phase factors. This innovative representation of polynomials has a wide range of applications in quantum computation. When the polynomial of interest is obtained by truncating an infinite polynomial series, a natural question is whether the phase factors have a well defined limit as the degree d→∞. While the phase factors are generally not unique, we find that there exists a consistent choice of parameterization so that the limit is well defined in the ℓ1 space. This generalization of QSP, called the infinite quantum signal processing, can be used to represent a large class of non-polynomial functions. Our analysis reveals a surprising connection between the regularity of the target function and the decay properties of the phase factors. Our analysis also inspires a very simple and efficient algorithm to approximately compute the phase factors in the ℓ1 space. The algorithm uses only double precision arithmetic operations, and provably converges when the ℓ1 norm of the Chebyshev coefficients of the target function is upper bounded by a constant that is independent of d. This is also the first numerically stable algorithm for finding phase factors with provable performance guarantees in the limit d→∞.