bluuebunny/crossref_metadata_2025 huggingface dataset:
Towards a sustained and fit-for-purpose European ocean observing and forecasting system
Authors: Tanhua Toste , Le Traon Pierre-Yves , Köstner Nicole , Eparkhina Dina , Navarro Gabriel , Dunbar Martha Bonnet , Speich Sabrina , Pascual Ananda , von Schuckmann Karina , Liguori Giovanni , Karstensen Johannes , Hassoun Abed El Rahman , van Doorn Erik , Barceló-Llull Bàrbara , Gómez Begoña Pérez , Cusack Caroline , Heslop Emma , Lara-Lopez Ana , Petihakis George , Telszewski Maciej , Palacz Artur P. , Wilmer-Becker Kirsten , Pearlman Jay , Muñiz Piniella Ángel , Heymans Johanna Jacomina , Lips Inga
Published: October 2024

The EU funded project EuroSea brought together key actors of the European ocean observing and forecasting communities with key users of the ocean observing products and services in order to better integrate existing ocean observation systems and tools, and to improve the delivery of ocean information to users. EuroSea was constructed around the ocean observing value chain that connects observations to users of ocean information, and, just as intended, the value chain concept was a useful prism to improve the system. In this article, we summarize some of the main take-home messages from EuroSea on the needs for developing the European Ocean Observing System and its links with modeling and forecasting systems. During the project, the challenges and gaps in the design and coordination of the European ocean observing and forecasting system were identified and mapped. Many gaps and challenges related to the observations of physical, chemical and biological Essential Ocean Variables were identified. Some of these gaps are related to technological developments, while others are caused by insufficient and short-term funding leading to a not sustainable system, management, and cooperation between different entities, as well as limitations in foresight activities, policies and decisions. This article represents a compilation of the broader needs for advancing the observing and forecasting system, and is meant as a guide for the community, and to funders and investors to advance ocean observing and the delivery of ocean information in Europe. To enhance the sustainability of ocean observations, which is paramount for a reliable provision of quality oceanographic data and services, several recommendations were compiled for ocean observing networks, frameworks, initiatives, as well as the ocean observing funders within the European nations, and the European Commission.
Differences in distribution and characteristics of microplastics in sediments of the south-eastern part of the Gulf of Trieste
Authors: Jamšek Jena , Prosen Helena , Bajt Oliver
Published: October 2024

Introduction

The Gulf of Trieste is prone to the accumulation of various pollutants and microplastics due to its geomorphological and hydrological characteristics. However, the distribution and sources of microplastics in this semi-enclosed area are poorly studied. The aim of our study was to determine the distribution and chemical composition of MP particles in the sediments of the Gulf of Trieste.

Methods

In this study, we collected 24 surface sediment samples using a Van Veen grab. Microplastics were extracted by density separation using NaCl. The size, shape, and color of the extracted microplastics were determined using an optical microscope, and the composition of the polymers was determined by Fourier transform infrared spectroscopy.

Results and discussion

The highest concentrations of up to 125 microplastic particles per 100 g dry sediment were found in coastal areas. Concentrations in the open sea were much lower, with an average of 3 particles per 100 g of sediment. Most of the microplastic was fibrous, made of polypropylene, 100–300 µm in size, and blue. This is the first study showing that microplastics are present in the sediments of the south-eastern part of the Gulf of Trieste. The findings suggest that microplastics exhibit a tendency to be retained within the sediment, leading to their accumulation primarily in a narrow coastal area rather than dispersing offshore. Our results will contribute to a better knowledge of the distribution and possible sources of plastics and microplastics in the Gulf of Trieste and even beyond in similar semi-enclosed marine areas.
A clinical study on the relationship between chronic rhinosinusitis and bronchial asthma
Authors: Kang Jing , Yong Hui , Zhang Zhijuan , Liu Jing , Gao Xiaoping , Shao Hui , Hou Li
Published: October 2024

Objective

To investigate the correlation between chronic rhinosinusitis (CRS) and bronchial asthma, focusing on the CRS without nasal polyps (CRSsNP) and CRS with nasal polyps (CRSwNP), as well as their impact on lung function.

Methods

A total of 141 patients diagnosed with chronic nasal-sinus inflammation were included in this study. Clinical data, including medical histories, nasal endoscopy scores, CT scores, symptom scores, and quality of life assessments, were collected.

Results

Among the patients with CRSsNP, 23.8% had concomitant bronchial asthma. The incidence of asthma was significantly associated with the severity of sinus involvement in CRSsNP patients (p = 0.049). Pulmonary function impairment was correlated with the severity of sinus inflammation in CRSsNP patients (p = 0.019). Quality of life was significantly affected in patients with concomitant asthma and CRSsNP or CRSwNP.

Conclusion

Chronic rhinosinusitis, both with and without nasal polyps, is closely correlated with bronchial asthma. Pulmonary function impairment is associated with the extent of inflammatory lesions in CRSsNP. Although CRSwNP does not significantly affect pulmonary function, the treatment of sinus diseases can contribute to the control of asthma.
A rare intestinal mucormycosis caused by Lichtheimia ramosa in a patient with diabetes: a case report
Authors: Liu Qinqin , Chen Ping , Xin Li , Zhang Jiahao , Jiang Meijie
Published: October 2024

Mucormycosis is an aggressive fungal disease. Gastrointestinal mucormycosis is rare, but its clinical symptoms lack specificity and mortality is high. Here, we report a case of intestinal mucormycosis caused by Lichtheimia ramosa in a 65-year-old woman with diabetes mellitus. The patient exhibited extensive mucosal tissue damage in the colon, with broad, undivided filamentous fungal hyphae present in the intestinal tissue. Therefore, the patient was suspected to have a filamentous fungal infection. Colonic tissue samples were obtained for fungal culture, and the fungus was identified as L. ramosa based on morphology and DNA sequencing. This case highlights the importance of pathologists and microbiologists in identifying pathogenic fungi and the significance of screening for mucormycosis in high-risk patient populations.
Computed tomography image quality in patients with primary hepatocellular carcinoma: intraindividual comparison of contrast agent concentrations
Authors: Peng Fei , Luo Chaotian , Ning Xiaojing , Xiao Fangyan , Guan Kaiming , Tang Cheng , Huang Fuling , Liang Junli , Peng Peng
Published: October 2024

Objective

This study aimed to assess the impact of the different concentrations of iodine contrast agents used on the quality of computed tomography (CT) images obtained intraindividually in hepatocellular carcinoma patients.

Methods

In this retrospective study, data from a cohort of 29 patients diagnosed with primary hepatocellular carcinoma who had undergone two preoperative CT-enhanced examinations within a 3-month timeframe were analyzed. Each patient was randomly assigned to receive either a low-concentration contrast agent (300 mg I/mL iohexol) or a high-concentration contrast agent (350 mg I/mL iohexol) for the first scan and the alternative contrast agent for the second scan. CT images of different liver regions of each patient were compared between low-and high-concentration scans using their before-and-after control design. Subjective image quality scores for portal vein images were also assessed.

Results

The findings of this study indicate that patients in the high-concentration group presented significantly elevated CT values across various anatomical regions, including the liver parenchyma, abdominal aorta, and hepatic portal vein, compared to those in the low-concentration group (p < 0.05). Moreover, the high-concentration group demonstrated superior subjective image ratings (p < 0.05). Nevertheless, there was no statistically significant difference in the CT values observed in liver cancer parenchyma scans at different phases between the two groups (p > 0.05).

Conclusion

In summary, using a high-concentration iodine contrast agent is efficient in enhancing the visual clarity of the liver parenchyma, the aorta, and the portal vein in individuals diagnosed with primary hepatocellular carcinoma.
MED-ChatGPT CoPilot: a ChatGPT medical assistant for case mining and adjunctive therapy
Authors: Liu Wei , Kan Hongxing , Jiang Yanfei , Geng Yingbao , Nie Yiqi , Yang Mingguang
Published: October 2024

Background

The large-scale language model, GPT-4-1106-preview, supports text of up to 128 k characters, which has enhanced the capability of processing vast quantities of text. This model can perform efficient and accurate text data mining without the need for retraining, aided by prompt engineering.

Method

The research approach includes prompt engineering and text vectorization processing. In this study, prompt engineering is applied to assist ChatGPT in text mining. Subsequently, the mined results are vectorized and incorporated into a local knowledge base. After cleansing 306 medical papers, data extraction was performed using ChatGPT. Following a validation and filtering process, 241 medical case data entries were obtained, leading to the construction of a local medical knowledge base. Additionally, drawing upon the Langchain framework and utilizing the local knowledge base in conjunction with ChatGPT, we successfully developed a fast and reliable chatbot. This chatbot is capable of providing recommended diagnostic and treatment information for various diseases.

Results

The performance of the designed ChatGPT model, which was enhanced by data from the local knowledge base, exceeded that of the original model by 7.90% on a set of medical questions.

Conclusion

ChatGPT, assisted by prompt engineering, demonstrates effective data mining capabilities for large-scale medical texts. In the future, we plan to incorporate a richer array of medical case data, expand the scale of the knowledge base, and enhance ChatGPT’s performance in the medical field.
Association of serum intact parathyroid hormone levels with sarcopenia in patients undergoing peritoneal dialysis
Authors: Hsu Bang-Gee , Wang Chih-Hsien , Tsai Jen-Pi , Chen Yi-Hsin , Hung Szu-Chun , Lin Yu-Li
Published: October 2024

Objective

Sarcopenia is highly prevalent in patients undergoing peritoneal dialysis (PD), contributing to adverse clinical outcomes. Animal models suggest that parathyroid hormone (PTH) induces muscle wasting through adipose tissue browning. However, the relationship between PTH dysregulation and sarcopenia in the PD population remains unclear. Thus, we aimed to explore the association between serum intact PTH levels and sarcopenia in PD patients.

Methods

We conducted a cross-sectional analysis using data from the Tzu-Chi PD cohort, comprising 186 PD patients with a mean age of 57.5 ± 14.1 years. Basic information, comorbidities, serum intact PTH levels, and other biochemical data were retrieved. Atherosclerotic cardiovascular disease (ASCVD) includes any history of coronary artery disease, myocardial infarction, peripheral arterial disease, and stroke. All patients were evaluated for appendicular skeletal muscle mass (ASM) using the Body Composition Monitor (BCM), handgrip strength, and 6-m usual gait speed. Sarcopenia was defined based on the consensus of the Asian Working Group for Sarcopenia 2019. Relative over-hydration (OH) was also assessed using BCM.

Results

The overall prevalence of sarcopenia was 38.2%. Across three groups of intact PTH levels (<150 pg/mL, 150–300 pg/mL, and >300 pg/mL), the prevalence rates of sarcopenia were 29.7, 36.4, and 46.2%, respectively (p for trend = 0.044). In the unadjusted model, age, ASCVD, subjective global assessment score, body mass index, relative OH, serum albumin, creatinine, phosphorus, and log-transformed intact PTH levels were significantly associated with sarcopenia. After full adjustment for all above factors, age (odds ratio [OR] = 1.04, 95% confidence interval [CI] = 1.00–1.08), ASCVD (OR = 4.12, 95% CI = 1.34–12.65), BMI (OR = 0.51, 95% CI = 0.41–0.64), relative OH (OR = 1.04, 95% CI = 1.00–1.07), log-transformed intact PTH levels (OR = 3.72, 95% CI = 1.51–9.14) were independently associated sarcopenia among PD patients.

Conclusion

Among PD patients, elevated serum intact PTH levels are independently associated with sarcopenia. Further longitudinal studies are warranted to confirm their causal relationship.
Comparison of two commercial broth microdilution panels for multidrug-resistant Gram-negative bacteria: Thermo Scientific™ Sensititre DKMGN vs. Beckman Coulter MicroScan NMDRM1
Authors: Aupaix Antoine , Lamraoui Kamila , Rodriguez-Villalobos Hector , Anantharajah Ahalieyah , Verroken Alexia
Published: October 2024

Introduction

Antimicrobial susceptibility testing (AST) using broth microdilution (BMD) is usually the reference method to obtain accurate minimum inhibitory concentrations and optimally manage infections with resistant organisms. Several commercial dry BMD are available for AST in clinical laboratories.

Materials and methods

Two commercial BMD panels for testing of multidrug-resistant Gram-negative bacteria were compared: the Thermo Scientific™ Sensititre DKMGN and the Beckman Coulter NMDRM1, for 17 antimicrobial agents.

Results

A total of 207 isolates were tested: three ATCC strains and one NCTC strain, six quality control strains from the Belgian National Antimicrobial Committee, and 197 clinical isolates, including carbapenem-resistant Enterobacterales, Pseudomonas aeruginosa, and Acinetobacter baumannii. The European Committee on Antimicrobial Susceptibility Testing (EUCAST) 2023 breakpoints version 13.1 were used to assign susceptibility categories.

Discussion

Overall, the categorical agreement (CA) and essential agreement (EA) were both above 90%, but several useful antibiotics for the treatment of multi-resistant organisms showed CA and EA under 90%, that is, meropenem, imipenem, and colistin for Enterobacterales and meropenem and colistin for P. aeruginosa. For Enterobacterales, the NMDRM1 panel showed a significantly higher resistance rate for meropenem, imipenem, amikacin, and colistin. For carbapenems, the minimal inhibitory concentrations (MICs) were underestimated by the DKMGN panel, as already pointed out by a warning on the EUCAST website. To better assess carbapenem susceptibility in carbapenem-resistant organisms, the DKMGN panel now requires the use of a higher inoculum in the insert kit. However, for a given isolate whose susceptibility to carbapenems is not known, there is a risk of underestimating the MIC values. Our results show that colistin testing remains a challenge, highlighting the urgent need for the development of more accurate commercial methods. The use of a single commercial method cannot guarantee good precision in the determination of the MIC value for colistin.
Dependence of aerosol-borne influenza A virus infectivity on relative humidity and aerosol composition
Authors: Motos Ghislain , Schaub Aline , David Shannon C. , Costa Laura , Terrettaz Céline , Kaltsonoudis Christos , Glas Irina , Klein Liviana K. , Bluvshtein Nir , Luo Beiping , Violaki Kalliopi , Pohl Marie O. , Hugentobler Walter , Krieger Ulrich K. , Pandis Spyros N. , Stertz Silke , Peter Thomas , Kohn Tamar , Nenes Athanasios
Published: October 2024

We describe a novel biosafety aerosol chamber equipped with state-of-the-art instrumentation for bubble-bursting aerosol generation, size distribution measurement, and condensation-growth collection to minimize sampling artifacts when measuring virus infectivity in aerosol particles. Using this facility, we investigated the effect of relative humidity (RH) in very clean air without trace gases (except ∼400 ppm CO2) on the preservation of influenza A virus (IAV) infectivity in saline aerosol particles. We characterized infectivity in terms of 99%-inactivation time, t99, a metric we consider most relevant to airborne virus transmission. The viruses remained infectious for a long time, namely t99 > 5 h, if RH < 30% and the particles effloresced. Under intermediate conditions of humidity (40% < RH < 70%), the loss of infectivity was the most rapid (t99 ≈ 15–20 min, and up to t99 ≈ 35 min at 95% RH). This is more than an order of magnitude faster than suggested by many previous studies of aerosol-borne IAV, possibly due to the use of matrices containing organic molecules, such as proteins, with protective effects for the virus. We tested this hypothesis by adding sucrose to our aerosolization medium and, indeed, observed protection of IAV at intermediate RH (55%). Interestingly, the t99 of our measurements are also systematically lower than those in 1-μL droplet measurements of organic-free saline solutions, which cannot be explained by particle size effects alone.
Age-related cerebral changes during different n-back tasks: a functional near-infrared spectroscopy study
Authors: Zhu Shizhe , Wang Qinglei , Kan Chaojie , Geng Ayan , Sui Youxin , Zhuang Ren , Zhu Yi , Wang Tong , Zhu Lan , Guo Chuan
Published: October 2024

Background

The n-back task is a widely used paradigm to assess working memory and is commonly applied in research on age-related cognitive decline. However, studies utilizing functional near-infrared spectroscopy (fNIRS) to explore this area are limited.

Objective

This study aims to investigate age-related differences in brain activation during the n-back task using fNIRS.

Methods

fNIRS data were collected from 18 elderly and 19 young participants while performing different n-back tasks. Brain activation patterns and peripheral performance were compared between the two groups.

Results

Significant differences in brain activation patterns were observed between elderly and young participants. Under the 3-back condition, the older group exhibited reduced activation in brain regions adjacent to prefrontal cognitive areas compared to the younger group. Additionally, the older group’s performance plateaued at the 2-back level, along with a decline in prefrontal activation.

Conclusion

These findings may suggest potential markers for cognitive decline, providing a new target for future screening.
Investigating causality and shared genetic architecture between body mass index and cognitive function: a genome-wide cross-trait analysis and bi-directional Mendelian randomization study
Authors: Chen Mingyi , Xu Xiaoxin , Wang Fang , Xu Xiaohong
Published: October 2024

Background and objectives

Observational studies have established a connection between body mass index (BMI) and an increased risk of cognitive decline. However, a comprehensive investigation into the causal relationships between BMI and cognitive function across diverse age groups, as well as the genetic underpinnings of this relationship, has been notably lacking. This study aims to investigate causality and the shared genetic underpinnings of between BMI and cognitive function by conducting a thorough genome-wide analysis, thereby provide valuable insights for developing personalized intervention strategies to promote cognitive health.

Methods

Genetic associations between BMI and cognitive function were thoroughly investigated through covariate genetic analysis and chained imbalance score regression, utilizing data from genome-wide association studies (GWAS). Bi-directional Mendelian Randomization (MR) was employed to uncover associations and potential functional genes were further scrutinized through Cross-trait meta-analysis and Summary-data-based MR (SMR). Subsequently, a detailed examination of the expression profiles of the identified risk SNPs in tissues and cells was conducted.

Results

The study found a significant negative correlation between BMI and cognitive function (β = −0.16, P = 1.76E-05), suggesting a causal linkage where higher BMI values were predictive of cognitive impairment. We identified 5 genetic loci (rs6809216, rs7187776, rs11713193, rs13096480, and rs13107325) between BMI and cognitive function by cross-trait meta-analysis and 5 gene-tissue pairs were identified by SMR analysis. Moreover, two novel risk genes TUFM and MST1R were shared by both cross-trait analysis and SMR analysis, which had not been observed in previous studies. Furthermore, significant enrichment of single nucleotide polymorphisms (SNPs) at tissue- and cell-specific levels was identified for both BMI and cognitive function, predominantly within the brain.

Conclusion

This study uncovers a causal relationship between BMI and cognitive function, with the discovery of TUFM and MST1R as shared genetic factors associated with both conditions. This novel finding offers new insights into the development of preventative strategies for cognitive decline in obese individuals, and further enhances our understanding of the underlying pathophysiology of these conditions. Furthermore, these findings could serve as a guide for the development of innovative therapeutic approaches to address cognitive decline in obese individuals.
Correlation between iron deposition and cognitive function in mild to moderate Alzheimer’s disease based on quantitative susceptibility mapping
Authors: Zhi Yuqi , Huang Ting , Liu Shanwen , Li Meng , Hu Hua , Liang Xiaoyun , Jiang Zhen , Zhu Jiangtao , Liu Rong
Published: October 2024

Background

Alzheimer’s disease (AD) is a complex neurodegenerative disorder characterized by progressively worsening cognitive decline and memory loss. Excessive iron accumulation produces severe cognitive impairment. However, there are no uniform conclusions about changes in brain iron content in AD. This study aimed to investigate the iron content of the deep brain nuclei in AD, and its correlation with cognitive function.

Methods

Thirty-one patients with mild to moderate AD, 17 patients with mild cognitive impairment (MCI), and 20 age-, sex-, and education-matched healthy controls (HC) were collected. The QSM was used to quantify the magnetic susceptibility values of the caudate nucleus, putamen, globus pallidus, substantia nigra, red nucleus, and dentate nucleus, and to analyze the differences that existed between the three groups. As well as the correlation between the magnetic susceptibility values and cognitive function was calculated.

Results

The magnetic susceptibility values of bilateral globus pallidus, left putamen, and bilateral substantia nigra were significantly higher in AD patients than in HC, and the magnetic susceptibility values of the right globus pallidus were significantly higher in AD patients than in MCI (all p < 0.05). The magnetic susceptibility values of the left dentate nucleus in the AD group were negatively correlated with the writing function of the MMSE subitem (r = −0.42, p = 0.020), and the magnetic susceptibility values of the left caudate nucleus and right dentate nucleus were significantly and negatively correlated with the naming function and language function of the MoCA subitem, respectively (r = −0.43, p = 0.019; r = −0.36, p = 0.048).

Conclusion

Magnetic susceptibility values based on QSM correlate with cognitive function are valuable in discriminating AD from MCI and AD from HC.
Arid3c identifies an uncharacterized subpopulation of V2 interneurons during embryonic spinal cord development
Authors: Renaux Estelle , Baudouin Charlotte , Schakman Olivier , Gay Ondine , Martin Manon , Marchese Damien , Achouri Younès , Rezsohazy René , Gofflot Françoise , Clotman Frédéric
Published: October 2024

Motor activity is organized by neuronal networks composed of motor neurons and a wide variety of pre-motor interneuron populations located in the brainstem and spinal cord. Differential expression and single-cell RNA sequencing studies recently unveiled that these populations subdivide into multiple subsets. However, some interneuron subsets have not been described yet, and the mechanisms contributing to this neuronal diversification have only been partly deciphered. In this study, we aimed to identify additional markers to further describe the diversity of spinal V2 interneuron populations. Here, we compared the transcriptome of V2 interneurons with that of the other cells of the embryonic spinal cord and extracted a list of genes enriched in V2 interneurons, including Arid3c. Arid3c identifies an uncharacterized subset of V2 that partially overlaps with V2c interneurons. These two populations are characterized by the production of Onecut factors and Sox2, suggesting that they could represent a single functional V2 unit. Furthermore, we show that the overexpression or inactivation of Arid3c does not alter V2 production, but its absence results in minor defects in locomotor execution, suggesting a possible function in subtle aspects of spinal locomotor circuit formation.
Targeting astrocytes polarization after spinal cord injury: a promising direction
Authors: Li Helin , Liu Ying , Sun Yucao , Guo Hangyu , Lv Shiyan , Guo Wenhui , Ren Jiyu , Wang Yufu , Zu Jianing , Yan Jinglong , Wang Nanxiang
Published: October 2024

Spinal cord injury (SCI) is a serious neurological injury that causes severe trauma to motor and sensory functions. Although long considered incurable, recent research has brought new hope for functional recovery from SCI. After SCI, astrocytes are activated into many polarization states. Here we discuss the two most important classical phenotypes: the ‘A1’ neurotoxic phenotype and the ‘A2’ neuroprotective phenotype, with A1 astrocytes being neurotoxic and impeding neurorecovery, and A2 astrocytes being neuroprotective. This paper discusses the changes in astrocyte responsiveness after SCI and the pros and cons of their polarization in SCI. It also elucidates the feasibility of astrocyte polarization as a therapeutic target for neuroprotection. In the future, multiple intervention strategies targeting astrocyte polarization are expected to gain wider clinical application, ultimately improving motor-sensory function and quality of life in SCI patients.
Circulating micronutrients levels and their association with the risk of endometriosis
Authors: Zhang Yanna , Li Meng , Zhang Feifei , Lin Jiaoya , Yuan Hong , Nian Qing
Published: October 2024

Background

Endometriosis, a prevalent gynecological disease, has an unclear pathogenesis. Micronutrients play a crucial role in disease development, which has led to an investigation of their association with endometriosis.

Methods

In this study, we analyzed the relationship between 15 micronutrients and endometriosis using both univariate and multivariate Mendelian randomization (MR) to assess the correlation. The results were validated using high-performance liquid chromatography (HPLC).

Results

The univariate MR analysis indicated that vitamin B6 (OR = 1.7060, 95% CI: 1.1796–2.4672, p = 0.0045) and calcium (OR = 1.4834, 95% CI: 1.0747–2.0475, p = 0.0165) are associated with an increased risk of endometriosis. Higher intakes of vitamin B6 and calcium are associated with a greater likelihood of developing endometriosis. The MR Egger regression’s intercept term demonstrated no evidence of pleiotropy (p > 0.05) or heterogeneity (p > 0.05) in the SNPs for calcium and vitamin B6. In multivariate MR analysis, vitamin B6 (OR = 2.397, 95% CI: 1.231–4.669, p = 0.01) was linked to an increased risk of endometriosis, independently of other exposure factors. No significant heterogeneity (p = 0.831) or pleiotropy (p = 0.369) was observed in the genetic variation of endometriosis, affirming the reliability of the multivariate MR analysis. HPLC confirmed a significant increase in serum levels of vitamin B6 and calcium, aligning with the MR analysis findings.

Conclusion

Vitamin B6 and calcium may be associated with this disease, with vitamin B6 potentially acting as an independent risk factor. Further research is essential to elucidate the role of micronutrients in disease, offering novel insights for prevention and treatment strategies.
Research trends in nutritional interventions for stroke: a bibliometric analysis and literature review
Authors: Xie Yipeng , Xiong Yuan , Sun Mengyue , Zhao Yan , Wu Miao
Published: October 2024

Background

Over the past 23 years, there has been a thorough analysis of literature concerning nutritional interventions, nutrients, and feeding approaches related to stroke. Furthermore, a scientific knowledge map was established, elucidating the current state of research, examining its development and trends, and offering new research viewpoints for the future. This study aimed to investigate global and emerging research trends in nutritional interventions for stroke from 2000 to 2023 through bibliometric analysis.

Methods

A bibliometric analysis of literature from the Core Collection of Scientific Networks for the years 2000–2022 was conducted. CiteSpace, VOSviewer, and bibliometric graphical software were used to identify major contributors to publications, including authors, countries, institutions, journals, references, and keywords.

Results

The bibliometric analysis yielded a total of 464 publications. This is a gradually increasing number in terms of the number of publications during the study period. China had the highest number of publications. Clinical Nutrition” was the journal with the highest number of relevant publications, and the most commonly used keywords were “stroke,” “nutrition” and “malnutrition.”

Conclusion

These analyses reveal research trends in nutritional therapy for stroke from 2000 to 2023 and point to prospective research frontiers. This study provides a deeper understanding of what nutritional treatment of stroke entails and provides guidance and support for future research in this area.
Efficacy and safety of Atractylodes macrocephala-containing traditional Chinese medicine combined with neoadjuvant chemotherapy in the treatment of advanced gastric cancer: a systematic evaluation and meta-analysis
Authors: Niu Xiaotao , Gu Haoqing , Li Jingzhan , Zuo Jiaqian , Ren Wenqin , Huang Yujie , Shu Xinyan , Jiang Chao , Shu Peng
Published: October 2024

Background

In China, Atractylodes-containing Chinese medicines are widely used as adjuvant therapy to neoadjuvant chemotherapy (NAC) in individuals diagnosed with advanced gastric cancer (AGC). Nevertheless, the findings concerning its effectiveness are still restricted. The aim from this research was to examine the efficiency and security Atractylodes macrocephala-containing traditional Chinese medicine together with NAC in the management of AGC.

Methods

Literature was systematically searched across 8 electronic databases until September 20, 2023. Two researchers conducted a thorough review of the selected studies. The primary outcome measures included the objective response rate (ORR), disease control rate (DCR), quality of life (QOL), adverse drug reactions (ADRs), and levels of peripheral blood lymphocytes. The relevant effect estimates are as follows as risk ratios (RR) or mean differences (MD) with corresponding 95% confidence intervals (CI). Credibility of information was evaluated using the GRADE analyzer.

Results

The results showed that solely on the basis of the accessible literature examined in NAC patients, individuals who received the therapeutic regimen containing Atractylodis Macrocephalae Chinese herbal preparations demonstrated a superior overall response rate (Relative Risk: 1.41, 95% confidence interval: 1.27-1.57, P < 0.001); DCR (RR: 1.20, 95% confidence interval: 1.13-1.27, P < 0.001), as compared to QOL (RR: 1.43, 95% confidence interval: 1.30-1.57, P < 0.001, MD: 8.47, 95% confidence interval: 7.16 - 9.77, P < 0.001); the proportions of CD3+ T-cells, CD4+ T-cells, CD8+ T-cells, CD4+CD8+ T-cells were increased; and the incidence of adverse reactions was decreased. Subgroup analyses showed that oral administration of all the traditional Chinese medicines containing Atractylodes macrocephala could improve tumor efficacy. Regardless of the duration of therapy of ≥8 weeks or <8 weeks, Atractylodes macrocephala-containing traditional Chinese medicine increased the tumor response in AGC patients. Combination of Atractylodes macrocephala-containing TCM with neoadjuvant chemotherapy increased ORR and DCR; when used in conjunction with cisplatin, only ORR was increased.

Conclusion

The combination of Atractylodes macrocephala-containing herbs with NAC in the treatment of AGC improves efficacy, improves prognosis, and reduces adverse effects. Nevertheless, additional high-quality randomized trials are required.

Systematic review registration

https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42023461079.
Gluconeogenesis and glycogenolysis required in metastatic breast cancer cells
Authors: Hicks Emily , Layosa Marjorie Anne , Andolino Chaylen , Truffer Caitlin , Song Yazhen , Heden Timothy D. , Donkin Shawn S. , Teegarden Dorothy
Published: October 2024

Introduction

Metabolic adaptability, including glucose metabolism, enables cells to survive multiple stressful environments. Glycogen may serve as a critical storage depot to provide a source of glucose during times of metabolic demand during the metastatic cascade; therefore, understanding glycogen metabolism is critical. Our goal was to determine mechanisms driving glycogen accumulation and its role in metastatic (MCF10CA1a) compared to nonmetastatic (MCF10A-ras) human breast cancer cells.

Methodology

13C6-glucose flux analysis in combination with inhibitors of the gluconeogenic pathway via phosphoenolpyruvate carboxykinase (PCK), the anaplerotic enzyme pyruvate carboxylase (PC), and the rate-limiting enzyme of the pentose phosphate pathway (PPP) glucose 6-phosphate dehydrogenase (G6PD). To determine the requirement of glycogenolysis for migration or survival in extracellular matrix (ECM) detached conditions, siRNA inhibition of glycogenolysis (liver glycogen phosphorylase, PYGL) or glycophagy (lysosomal enzyme α-acid glucosidase, GAA) enzymes was utilized.

Results

Metastatic MCF10CA1a cells had 20-fold greater glycogen levels compared to non-metastatic MCF10A-ras cells. Most glucose incorporated into glycogen of the MCF10CA1a cells was in the five 13C-containing glucose (M+5) instead of the expected M+6 glycogen-derived glucose moiety, which occurs through direct glucose conversion to glycogen. Furthermore, 13C6-glucose in glycogen was quickly reduced (~50%) following removal of 13C-glucose. Incorporation of 13C6-glucose into the M+5 glucose in the glycogen stores was reduced by inhibition of PCK, with additional contributions from flux through the PPP. Further, inhibition of PC reduced total glycogen content. However, PCK inhibition increased total unlabeled glucose accumulation into glycogen, suggesting an alternative pathway to glycogen accumulation. Inhibition of the rate-limiting steps in glycogenolysis (PYGL) or glycophagy (GAA) demonstrated that both enzymes are necessary to support MCF10CA1a, but not MCF10A-ras, cell migration. GAA inhibition, but not PYGL, reduced viability of MCF10CA1a cells, but not MCF10A-ras, in ECM detached conditions.

Conclusion

Our results indicate that increased glycogen accumulation is primarily mediated through the gluconeogenesis pathway and that glycogen utilization is required for both migration and ECM detached survival of metastatic MCF10CA1a cells. These results suggest that glycogen metabolism may play an important role in the progression of breast cancer metastasis.
Evolutionary development of mother–child scaffolding for moral comprehension
Authors: Beck Robert J.
Published: October 2024

This evolutionary developmental study employed an experimental recursive narrative ecological niche, comparing scaffolded mother–child (5-year-old) pairs to unassisted controls as they independently viewed and discussed a realistic fictional family video depicting a father–daughter emotional conflict over the girl’s risky behavior, which violated harm/care and fairness/justice moral foundation norms. A microgenetic analysis was conducted on a selected variant pair that demonstrated high adaptive fitness in the niche by employing developmentally advanced cooperative scaffolding tools. The conversational ecosystem phase was characterized by repeated maternal theory-oriented “why” questions and coordinated child causal responses, forming a joint epistemic investigation that facilitated the child’s moral understanding of the characters’ responsibilities and motives. The pair used quasi-justice procedures to gather evidence, judge, and construct moral attributes for the characters. Their conversational mechanism was supported by mutual mindreading, mental time travel, and empathic communications, as they interacted simultaneously with each other and the story characters. A narrative ecological scaffolding theory emerged, establishing a standard for cooperative epistemic scaffolding between the mother and the child. Future training programs should utilize the Zone of Proximal Development method to instruct similar parent–child pairs.
Democrats and Republicans choose solar panels in very similar ways
Authors: Johnson Nathanael , Reimer Torsten
Published: October 2024

Introduction

Appealing to individuals’ social identity is a powerful form of social influence, capable of changing the way people process information, the information they think about, and how they evaluate other individuals. The purpose of this study is to explore the idea that Democrat and Republican environmental norms may impact the attributes and strategies partisans use when choosing whether to have solar panels on a house.

Methods

An online study with N = 363 participants was conducted to examine these possible effects through multi-attribute decision making, applying predefined decision process models to participant behavior to test which attribute-based models best describe participants’ decision making. A choice task was combined with an experimental manipulation of political affiliation salience to examine whether the norms of political groups would have influence on decision behavior.

Results

Results of the study show remarkable similarities between political parties in their strategies for choosing solar panels. Members of both political parties appeared to use similar strategies and similar attributes for the formation of their decisions.

Discussion

Recommendations are made that science communicators and policy makers avoid polarizing language so as not to create unnecessary polarization where ideological gaps may not currently exist.
Exploring the impact of stimulant medications on weight in children with attention deficit hyperactivity disorder in Dubai, United Arab Emirates
Authors: Al Eid Faten , Albanna Ammar , Joseph Jessie , Talo Sami , Jeyaseelan Lakshmanan , Sultan Meshal A.
Published: October 2024

Objective

Attention deficit hyperactivity disorder (ADHD), prevalent in 5% of children worldwide, impacts academic performance and often coexists with psychiatric disorders. Psychostimulant medications are primary treatments for ADHD, enhancing dopamine to reduce symptoms. However, dopamine increase may cause appetite loss. This pioneering study in the United Arab Emirates (UAE) explores psychostimulant effects on weight in children diagnosed with ADHD, aiming to uncover unique regional characteristics and contributing factors to weight changes.

Methods

This retrospective cohort study assessed data from electronic medical records from 2017 to 2022, aiming to assess the impact of psychostimulants on weight in children aged 6–18 years. Inclusion criteria covered psychostimulant-treated and untreated patients with ADHD. Statistical analysis, involving longitudinal data methods aimed to demonstrate significant weight differences.

Results

Data from 107 pediatric patients diagnosed with ADHD were analyzed, with 86 meeting inclusion criteria. Most patients were male (80.2%). ADHD presentations varied, and methylphenidate immediate release was the most prescribed stimulant medication. Patients experienced initial weight loss followed by overall gain over 12 months. Coexisting conditions, maternal factors, family history, and correlations with autism spectrum disorder were explored.

Conclusion

This study provides valuable insights into the effects of psychostimulant medications on the weight of children and adolescents diagnosed with ADHD in the UAE. It suggests avenues for future research, emphasizing extended follow-ups to understand long-term psychostimulant effects, nuanced examinations of age and gender, and exploring interactions with comorbidities. Despite limitations, the research provides insights into ADHD medication effects, guiding personalized treatment approaches for pediatric populations.
Characterizing impulsivity in individuals with methamphetamine and methcathinone use disorders
Authors: Yin Jie , Cheng Xinyu , Zhou Chendi , Xu Lin , Yang Bo , Yuan Ti-Fei
Published: October 2024

Background

Individuals with substance use disorder (SUD) are characterized by loss of control in drug use, such as increased impulsivity. Methamphetamine and methcathinone are psychostimulants, the use of which is accompanied by a high level of impulsivity. Whether individuals with methamphetamine use disorder (MUD) and methcathinone use disorder (MCUD) differ in different aspects of impulsivity is unclear.

Methods

We investigated impulsivity traits and behaviors in individuals with MUD and MCUD. The Barratt Impulsiveness Scale (BIS), Sensation Seeking Scale (SSS), and delay discounting task (DDT) were assessed in individuals with MUD and MCUD and in healthy controls (HCs); then, we performed network-based analysis and computational modeling to understand the potential differences among the three groups.

Results

MUD subjects scored higher than MCUD subjects in terms of motor impulsivity, nonplanning impulsivity, and total BIS scores. The network analysis revealed that there were no significant differences between MUD and MCUD subjects in any centrality indices. The discount rate of MUD and MCUD subjects was significantly greater than that of HCs, whereas there was no difference in the discount rate between the two addiction groups.

Conclusions

These findings suggest that MUD and MCUD participants differ in impulsivity traits but not in impulsive behaviors, implying that impulsive traits and behaviors represent different aspects of impulsivity.
Hypnotherapy modulating early and late event-related potentials components of face processing in social anxiety
Authors: Zhang Han , Xue Xinrong , Wen Jialin , Li Yongyi , Fan Chuan , Ma Lijun , Wang Huixue , Zhang Mi , Zhang Shuyu , Hu Die , Wang Kai , Li Xiaoming
Published: October 2024

Background

Hypnotherapy has a potential role in modulating attention bias to treat social anxiety disorder (SAD). This study aimed to verify whether hypnotherapy can reduce social anxiety by changing attentional bias. The primary objective of our study is to explore the influence of hypnosis on various aspects of attention processes, specifically focusing on how it affects attention bias and social anxiety.

Methods

This study included 69 participants with SAD who were assigned to three groups based on their scores on the Liebowitz Social Anxiety Scale (LSAS). The experimental group (n = 23) received a hypnosis treatment once a week, for a total of six sessions, while the control group (n = 23) and the baseline group (n = 23) did not receive any treatment. To evaluate whether hypnosis could alleviate SAD and attention bias towards threatening stimuli, we employed questionnaires and an odd-one-out task accompanied by electroencephalography (EEG) recordings.

Results

Under the attention sensitivity conditions, the experimental group exhibited a reduced N170 and LPP at the posttest stage, and a similar N170 and LPP reduction under the attention disengagement conditions. Notably, the symptom improvements were positively correlated with the reduction in N170 and LPP amplitude across conditions.

Conclusion

Hypnosis treatment modulates the early face processing and late emotional evaluation of threat-related stimuli in SAD patients. These findings suggest that N170 and LPP are important biomarkers for the treatment of SAD.
Qualitative analysis of emotional distress in burns, plastic and reconstructive surgery patients from the perspectives of cognitive and metacognitive models
Authors: Taylor-Bennett Joseph , Capobianco Lora , Wisely Julie , Wells Adrian
Published: October 2024

Introduction

Burns and other injuries requiring plastic and/or reconstructive surgery (BPRS) are lifechanging, often unexpected, and increase the risk of psychiatric morbidity. There are no published studies we are aware of that explores the applicability of psychological models to BPRS patients. Cognitive behavioural therapy (CBT) is the benchmark treatment in mental health but may be less effective in physical health settings. Metacognitive therapy (MCT)can be more effective than CBT in mental health settings and shows promise in reducing anxiety and depression symptoms in people with cancer and cardiac disease. The present study explored the psychological experiences (feelings, thoughts, and coping strategies) of BPRS patients, and whether the concepts underpinning cognitive and metacognitive models can be elicited from these accounts.

Method

Semi structured interviews were conducted with 11 patients recruited from a BPRS psychology service. Data was analysed using Thematic Analysis. Patients described a range of emotions including low mood, anxiety, anger, guilt, loss, and negative thinking.

Results

From the perspective of the cognitive model, there were examples of each of 10 pre-specified distorted thinking types (cognitive distortions), and patient talk seemed to fit problem-specific cognitive models. From the perspective of the metacognitive model, all patients described the “cognitive attentional syndrome,” i.e., how they engaged in repetitive negative thinking (worry, rumination) and thought-focused regulation strategies. Patient talk also demonstrated both positive and negative metacognitive beliefs.

Conclusion

The implications of applying the findings from each model to clinical practice are discussed. The metacognitive model may offer benefits in clinical practice that should be investigated further.