bluuebunny/crossref_metadata_2025 huggingface dataset:
Chaotic Phenomena, Sensitivity Analysis, Bifurcation Analysis, and New Abundant Solitary Wave Structures of The Two Nonlinear Dynamical Models in Industrial Optimization
Authors: Miah M. Mamun , Alsharif Faisal , Iqbal Md. Ashik , Borhan J. R. M. , Kanan Mohammad
Published: June 2024

In this research, we discussed the different chaotic phenomena, sensitivity analysis, and bifurcation analysis of the planer dynamical system by considering the Galilean transformation to the Lonngren wave equation (LWE) and the (2 + 1)-dimensional stochastic Nizhnik–Novikov–Veselov System (SNNVS). These two important equations have huge applications in the fields of modern physics, especially in the electric signal in data communication for LWE and the mechanical signal in a tunnel diode for SNNVS. A different chaotic nature with an additional perturbed term was also highlighted. Concerning the theory of the planer dynamical system, the bifurcation analysis incorporating phase portraits of the dynamical systems of the declared equations was performed. Additionally, a sensitivity analysis was used to monitor the sensitivity of the mentioned equations. Also, we extracted new, abundant solitary wave structures with the graphical phenomena of the mentioned nonlinear mathematical models. By conducting an expansion method on the abovementioned equations, we generated three types of soliton structures, which are rational function, trigonometric function, and hyperbolic function. By simulating the 3D, contour, and 2D graphs of these obtained solitons, we scrutinized the behavior of the waves affecting the nonlinear terms. The figures show that the solitary waves obtained from LWE are efficient in analyzing electromagnetic wave signals in the cable lines, and the solitary waves from SNNVS are essential in any stochastic system like a sound wave. Moreover, by taking some values of the parameters, we found some interesting soliton shapes, such as compaction soliton, singular periodic solution, bell-shaped soliton, anti-kink-shaped soliton, one-sided kink-shaped soliton, and some flat kink-shaped solitons, etc. This article will have a great impact on nonlinear science due to the new solitary wave structures with different complex phenomena, sensitivity analysis, and bifurcation analysis.
Comment on Takakura et al. Acupuncture for Japanese Katakori (Chronic Neck Pain): A Randomized Placebo-Controlled Double-Blind Study. Medicina 2023, 59, 2141
Authors: Birch Stephen , Alraek Terje , Kim Tae-Hun , Lee Myeong Soo
Published: June 2024

We are writing because we have a number of concerns about the Takakura et al. [...]
C-Reactive Protein as a Predictor of Severe Respiratory Complications in Measles
Authors: Popović Dragonjić Lidija , Ranković Aleksandar , Ćosić Petković Milica , Cvetanović Maja , Miladinović Jelena , Jović Andrija , Tomić Jovana , Stojanović Nikola M.
Published: June 2024

Background and Objectives: Even though measles is easily prevented by vaccination, infection outbreaks are not rare. Infection carries a great risk for pulmonary complications, which are sometimes hard to predict, especially in a group of outpatients. This study aims to evaluate the association between serum CRP changes and the severity of respiratory complications in the group of inpatients treated for measles. Materials and Methods: A total of 207 patients admitted and treated at the Clinic for Infectious Diseases, University Clinical Center, Nis, for measles infection were included in the analysis. The data collected from the patients’ medical records included demographic characteristics, disease duration, blood and serum biochemical analysis, general measles-associated symptoms, and disease outcome. Results: Results of the study revealed that there are almost no differences in the clinical presentation of patients with measles and those complicated with pneumonia. The examined CRP changes are found to correlate with the observable degree of pneumonia; however, they do not correspond to the changes visible in chest X-rays. Conclusions: CRP changes in the serum of patients with measles with mild clinical pictures could be a potential predictor for the development of some pulmonary complications.
Robot-Assisted Radical Prostatectomy (RARP) Trifecta Learning Curve for Surgeons with Previous Experience in Laparoscopy
Authors: Carlos Altez-Fernandez , Dario Vazquez-Martul , Popescu Răzvan-Ionut , Mariela Corrales , Venancio Chantada-Abal
Published: June 2024

Background and Objectives: Robot-assisted radical prostatectomy (RARP) is a complex surgery with a steep learning curve (LC). No clear evidence exists for how previous laparoscopic experience affects the RARP LC. We report the LC of three surgeons with vast experience in laparoscopy (more than 400 procedures), analyzing the results of functional and oncological outcomes under the “Trifecta” concept (defined as the achievement of continence, potency, and oncological control free of biochemical recurrence). Materials and Methods: The surgical experience of the three surgeons from September 2021 to December 2022, involving 146 RARP consecutive patients in a single institution center, was evaluated prospectively. Erectile disfunction patients were excluded. ANOVA and chi-square test were used to compare the distribution of variables between the three surgeons. LC analysis was performed using the cumulative sum control chart (CUSUM) technique to achieve trifecta. Results: The median age was 65.42 (±7.34); the clinical stage were T1c (68%) and T2a (32%); the biopsy grades were ISUP 1 (15.9%), ISUP 2 (47.98), and ≥ISUP 3 (35%). The median surgical time was 132.8 (±32.8), and the mean intraoperative bleeding was 186 cc (±115). Complications included the following: Clavien–Dindo I 8/146 (5.47%); II 9/146 (6.16%); and III 3/146 (2.05%). Positive margins were reported in 44/146 (30.13%). The PSA of 145/146 patients (99%) at 6 months was below 0.08. Early continence was achieved in 101/146 (69.17%), 6-month continence 126/146 (86%), early potency 51/146 (34.9%), and 6-month potency 65/146 (44%). Surgeons “a”, “b”, and “c” performed 50, 47, and 49 cases, respectively. After CUSUM analysis, the “Trifecta” LC peak was achieved at case 19 in surgeon “a”, 21 in surgeon “b”, and 20 in surgeon “c”. Conclusions: RARP LC to accomplish “Trifecta” can be significantly reduced in surgeons with previous experience in laparoscopy and be achieved at around 20 cases.
Modeling of Zirconium Atom Redistribution and Phase Transformation Coupling Behaviors in U-10Zr-Based Helical Cruciform Fuel Rods under Irradiation
Authors: Chen Xingdi , Xie Zhexiao , Mao Xiaoxiao , Ding Shurong
Published: June 2024

Uranium–zirconium metal-based Helical Cruciform Fuels (HCFs) have shown a promising prospect for their use in advanced nuclear reactors. However, during irradiation, dual-phase coexistence and the spatial heterogeneous distribution of zirconium atoms occur at higher powers, affecting the thermo-mechanical coupling behaviors and safety of fuel elements and assemblies. In this study, based on the phase-field approach, the coupled multi-field governing equations to describe the zirconium diffusion and phase evolution for U-Zr metallic fuels are improved. Furthermore, the corresponding numerical algorithms and procedures for multi-field coupling calculations are developed. The numerical predictions of zirconium atom fraction are in good agreement with the relevant experimental results, validating the developed models, algorithms and programs. The zirconium atom redistribution and phase transformation coupling behaviors in high-power U-10wt%Zr-based HCF rods are also obtained. Moreover, the complex evolution mechanisms of multi-field variables are analyzed. The results indicate the following: (1) the irradiation enhancement of the thermal mobility and chemical mobility plays a critical role in the redistribution of Zr atoms; (2) the multi-field results of HCF rods have helical symmetric characteristics; (3) the contribution competitions of the temperature gradient and chemical potential gradient within the α phase and γ phase significantly influence the zirconium-atom redistribution, with the zirconium-rich zones formed in the elbow region and the zirconium-poor zones appearing inside. These research efforts supply a foundation for the further involvement of mechanical fields in multi-field coupling computation.
The Cellular Stability Hypothesis: Evidence of Ferroptosis and Accelerated Aging-Associated Diseases as Newly Identified Nutritional Pentadecanoic Acid (C15:0) Deficiency Syndrome
Authors: Venn-Watson Stephanie
Published: June 2024

Ferroptosis is a newly discovered form of cell death caused by the peroxidation of fragile fatty acids in cell membranes, which combines with iron to increase reactive oxygen species and disable mitochondria. Ferroptosis has been linked to aging-related conditions, including type 2 diabetes, cardiovascular disease, and nonalcoholic fatty liver disease (NAFLD). Pentadecanoic acid (C15:0), an odd-chain saturated fat, is an essential fatty acid with the primary roles of stabilizing cell membranes and repairing mitochondrial function. By doing so, C15:0 reverses the underpinnings of ferroptosis. Under the proposed “Cellular Stability Hypothesis”, evidence is provided to show that cell membranes optimally need >0.4% to 0.64% C15:0 to support long-term health and longevity. A pathophysiology of a newly identified nutritional C15:0 deficiency syndrome (“Cellular Fragility Syndrome”) is provided that demonstrates how C15:0 deficiencies (≤0.2% total circulating fatty acids) can increase susceptibilities to ferroptosis, dysmetabolic iron overload syndrome, type 2 diabetes, cardiovascular disease, and NAFLD. Further, evidence is provided that C15:0 supplementation can reverse the described C15:0 deficiency syndrome, including the key components of ferroptosis. Given the declining dietary intake of C15:0, especially among younger generations, there is a need for extensive studies to understand the potential breadth of Cellular Fragility Syndrome across populations.
Haemotrophic Mycoplasmas Infecting Pigs: A Review of the Current Knowledge
Authors: Ade Julia , Eddicks Matthias , Ritzmann Mathias , Hoelzle Katharina , Hoelzle Ludwig E. , Stadler Julia
Published: June 2024

Haemotrophic mycoplasmas (haemoplasmas) are a group of highly specific and adapted bacteria. Three different haemoplasma species in pigs are known to date: Mycoplasma (M.) suis, M. parvum and ‘Candidatus (Ca.) M. haemosuis’. Even though these bacteria have been known in pig farming for a long time, it is difficult to draw general conclusions about the relevance of their infections in pigs. This review summarizes the current knowledge on the three porcine haemoplasma species with regards to clinical and pathological descriptions, pathobiology, epidemiology and diagnostics as well as prevention and therapy. Overall, it is clear that considerably more data are available for M. suis than for the other two species, but generally, porcine haemoplasmas were found to be highly prevalent all over the world. Mycoplasma suis is the most virulent species, causing acute infectious anaemia in pigs (IAP), whereas M. parvum usually results in chronic and subclinical infections associated with performance losses. Little is known about the clinical significance of the recently discovered third porcine species ‘Ca. M. haemosuis’. So far, the described pathogenic mechanisms mainly include direct destruction of erythrocytes via adhesion, invasion, eryptosis and nutrient scavenging, indirect erythrocyte lysis due to immune-mediated events and immune dysregulation processes. A review of published diagnostic data confirms PCR assays as the current standard method, with various cross-species and species-specific protocols. Overall, there is a need for further examination to obtain valuable insights for practical application, specifically regarding the importance of subclinical infections in naturally infected animals. An essential requirement for this will be to gain a more comprehensive understanding of the mechanisms operating between the host and the pathogen.
Shifts in Microbial Community Structure and Co-occurrence Network along a Wide Soil Salinity Gradient
Authors: Li Yan , Wang Juan , Li Eryang , Yang Xiaodong , Yang Jianjun
Published: June 2024

The response of microbiomes to salinity has been clarified in different geographic scales or ecosystems. However, how soil microbial community structure and interaction respond to salinity across wide salinity range and climatic region is still unclearly resolved. To address this issue, we examined the microbial community’s composition in saline soils from two climatic regions (coastal wetland and arid desert). Our research confirms that soil salinity had a negative effect on soil nutrient content. Salinity decreased the relative abundance of bacteria, but increased archaea abundance, leading to the shifts from bacteria dominant community to archaea dominant community. Low-water medium-salinity soil (LWMS) had the most complex archaeal community network, whereas for bacteria, the most complex bacterial community network was observed in low-water high-salinity soils (LWHS). Key microbial taxa differed in three salinity gradients. Salinity, soil water content, pH, total nitrogen (TN), and soil organic carbon (SOC) were the main driving factors for the composition of archaeal and bacterial community. Salinity directly affected archaeal community, but indirectly influenced bacteria community through SOC; pH affected archaeal community indirectly through TN, but directly affected bacterial community. Our study suggests that soil salinity dramatically influences diversity, composition, and interactions within the microbial community.
The Value of Ursodeoxycholic Acid and Mesenchymal Stem Cells in the Treatment of Severe COVID-19
Authors: Zheng Qi , Li Yuetong , Sheng Guoping , Li Lanjuan
Published: June 2024

Objective: The objective of this study was to evaluate the therapeutic efficacy of ursodeoxycholic acid (UDCA) and mesenchymal stem cells (MSCs) in patients with severe COVID-19. Methods: We included severe COVID-19 patients hospitalized at Shulan (Hangzhou) Hospital between December 2022 and June 2023. We used a logistic regression model to compare the use of UDCA and MSCs in the two distinct groups of improved and poor outcomes. It is noteworthy that the deterioration group encompassed instances of both death and abandonment of treatment. The receiver operating characteristic (ROC) curve was plotted to assess the performance of the model. The aim was to assess the therapeutic effect of UDCA and MSCs on the outcome of severe COVID-19 patients. Results: A total of 167 patients with severe COVID-19 were included in this study. The analysis revealed that out of 42 patients (25.1%), 17 patients (10.2%) had taken UDCA, and 17 patients (10.2%) had used MSCs. Following a multivariable logistic regression, the results indicated a negative association between UDCA treatment (OR = 0.38 (0.16–0.91), p = 0.029), MSCs treatment (OR = 0.21 (0.07–0.65), p = 0.007), and the risk of severe COVID-19 mortality. Additionally, age showed a positive association with the risk of mortality (OR = 1.03 (1.01–1.07), p = 0.025). Conclusions: UDCA and MSCs have shown potential in improving the prognosis of severe COVID-19 patients and could be considered as additional treatments for COVID-19 in the future.
Exploring Pathogen Presence Prediction in Pastured Poultry Farms through Transformer-Based Models and Attention Mechanism Explainability
Authors: Ram Das Athish , Pillai Nisha , Nanduri Bindu , Rothrock Michael J. , Ramkumar Mahalingam
Published: June 2024

In this study, we explore how transformer models, which are known for their attention mechanisms, can improve pathogen prediction in pastured poultry farming. By combining farm management practices with microbiome data, our model outperforms traditional prediction methods in terms of the F1 score—an evaluation metric for model performance—thus fulfilling an essential need in predictive microbiology. Additionally, the emphasis is on making our model’s predictions explainable. We introduce a novel approach for identifying feature importance using the model’s attention matrix and the PageRank algorithm, offering insights that enhance our comprehension of established techniques such as DeepLIFT. Our results showcase the efficacy of transformer models in pathogen prediction for food safety and mark a noteworthy contribution to the progress of explainable AI within the biomedical sciences. This study sheds light on the impact of effective farm management practices and highlights the importance of technological advancements in ensuring food safety.
Caldanaerobacter subterraneus subsp. keratinolyticus subsp. nov., a Novel Feather-Degrading Anaerobic Thermophile
Authors: Mashzhan Akzhigit , Kistaubayeva Aida , Javier-López Rubén , Bissenbay Akerke , Birkeland Nils-Kåre
Published: June 2024

Caldanaerobacter subterraneus subsp. keratinolyticus subsp. nov. strain KAk was isolated from a geothermal hot spring located in Kazakhstan. Growth occurred at temperatures ranging from 50 to 80 °C, with approximately 70 °C as optimum. It also thrived in pH conditions ranging from 4.0 to 9.0, with the best growth occurring at 6.8. Under optimal conditions in a glucose-containing medium, the cells were predominantly observed singly, in pairs, or less frequently in chains, and did not form endospores. However, under conditions involving growth with merino wool or feathers, or under suboptimal conditions, the cells of strain KAk exhibited a notably elongated and thinner morphology, with lengths ranging from 5 to 8 µm, and spores were observed. The KAk strain exhibited efficient degradation of feather keratin and merino wool at temperatures ranging from 65 to 70 °C. Analysis of the 16S rRNA gene sequence placed KAk within the genus Caldanaerobacter, family Thermoanaerobacteraceae, with the highest similarity to C. subterraneus subsp. tengcongensis MB4T (98.84% sequence identity). Furthermore, our analysis of the draft genome sequence indicated a genome size of 2.4 Mbp, accompanied by a G+C value of 37.6 mol%. This study elucidated the physiological and genomic characteristics of strain KAk, highlighting its keratinolytic capabilities and distinctiveness compared to other members of the genus Caldanaerobacter.
Hemotrophic Mycoplasmas—Vector Transmission in Livestock
Authors: Arendt Mareike , Stadler Julia , Ritzmann Mathias , Ade Julia , Hoelzle Katharina , Hoelzle Ludwig E.
Published: June 2024

Hemotrophic mycoplasmas (HMs) are highly host-adapted and specialized pathogens infecting a wide range of mammals including farm animals, i.e., pigs, cattle, sheep, and goats. Although HMs have been known for over 90 years, we still do not know much about the natural transmission routes within herds. Recently, it has been repeatedly discussed in publications that arthropod vectors may play a role in the transmission of HMs from animal to animal. This is mainly since several HM species could be detected in different potential arthropod vectors by PCR. This review summarizes the available literature about the transmission of bovine, porcine, ovine, and caprine HM species by different hematophagous arthropod vectors. Since most studies are only based on the detection of HMs in potential vectors, there are rare data about the actual vector competence of arthropods. Furthermore, there is a need for additional studies to investigate, whether there are biological vectors in which HMs can multiply and be delivered to new hosts.
Alfalfa Spring Black Stem and Leaf Spot Disease Caused by Phoma medicaginis: Epidemic Occurrence and Impacts
Authors: Lan Yanru , Zhou Wennan , Duan Tingyu , Li Yanzhong , Matthew Cory , Nan Zhibiao
Published: June 2024

Alfalfa spring black stem and leaf spot disease (ASBS) is a cosmopolitan soil-borne and seed-borne disease caused by Phoma medicaginis, which adversely affects the yield, and nutritive value and can stimulate production of phyto-oestrogenic compounds at levels that may adversely affect ovulation rates in animals. This review summarizes the host range, damage, and symptoms of this disease, and general features of the infection cycle, epidemic occurrence, and disease management. ASBS has been reported from over 40 countries, and often causes severe yield loss. Under greenhouse conditions, reported yield loss was 31–82% for roots, 32–80% for leaves, 21% for stems and 26–28% for seedlings. In field conditions, the forage yield loss is up to 56%, indicating that a single-cut yield of 5302 kg/ha would be reduced to 2347 kg/ha. P. medicaginis can infect up to 50 species of plants, including the genera Medicago, Trifolium, Melilotus, and Vicia. ASBS is more severe during warm spring conditions before the first harvest than in hot summer and cooler winter conditions, and can infect alfalfa roots, stems, leaves, flowers, pods, and seeds, with leaf spot and/or black stem being the most typical symptoms. The primary infection is caused by the overwintering spores and mycelia in the soil, and on seeds and the cortex of dead and dry stems. The use of resistant cultivars is the most economical and effective strategy for the control of ASBS. Although biological control has been studied in the glasshouse and is promising, chemical control is the main control method in agriculture.
Screening of the Biocontrol Efficacy of Potent Trichoderma Strains against Fusarium oxysporum f.sp. ciceri and Scelrotium rolfsii Causing Wilt and Collar Rot in Chickpea
Authors: Kumari Ranjna , Kumar Vipul , Arukha Ananta Prasad , Rabbee Muhammad Fazle , Ameen Fuad , Koul Bhupendra
Published: June 2024

Chickpeas contribute to half of the pulses produced in India and are an excellent source of protein, fibers, carbohydrates, minerals, and vitamins. However, the combination of the wilt and root rot diseases drastically lowers its yield. The use of antagonist microbes that restrict the growth of other phytopathogens is an ecofriendly approach to combat the serious threats raised by the plant pathogens. Trichoderma spp. are well known as biocontrol agents, especially against soil- and seed-borne phytopathogens. In this study, 21 Trichoderma isolates that were collected from different rhizospheric soils were evaluated against two notorious soil-borne pathogens, such as Fusarium oxysproum f.sp. ciceri and Sclerotium rolfsii. The maximum percentage of inhibition against the tested pathogens was observed in Trichoderma isolate PBT13 (72.97%, 61.1%) followed by PBT3 (72.23%, 59.3%). The mycelial extension rate method, dual culture (antagonism), production of cell-wall degrading enzymes (CWDs), and antifungal metabolites (by GC-MS) were used as selection criteria for potent Trichoderma isolates. Among the 21 isolates, PBT3, PBT4, PBT9, and PBT13 exhibited high antagonistic activity, production of antifungal metabolites, and chitinase and β-1,3-glucanase activity. These four species were subjected to molecular characterization using an internal transcribed spacer (ITS 1 and ITS4). The results of molecular characterization identified the four species as T. virnes, T. asperellum, T. lixii, and T. harzianum. Moreover, significant chitinase and β-1,3-glucanase activities of all Trichoderma isolates were recorded in the growth medium. Trichoderma harzianum (isolate PBT13) was found to exhibit the highest chitinase activity in terms of zone formation (4.40 ± 0.17 cm), whereas Trichoderma virens (isolate PBT3) exhibited the highest β-1,3-glucanase activity1.511 μmole/min. A GC-MS analysis of ethyl extracts from two isolates of Trichoderma (PBT9, PBT13) revealed the presence of 28 VOCs. Overall, this study suggests that these four Trichoderma strains are promising biological control agents (BCAs) and could be developed as bio-pesticides after stringent field trials for the management of soil-borne diseases of chickpeas.
Preparation of Pinoresinol and Dehydrodiconiferyl Alcohol from Eucommiae Cortex Extract by Fermentation with Traditional Mucor
Authors: Jiang Wenyi , He Zhengyou , Yao Ruijiao , Chen Zhiyang , Zeng Xia , Zheng Miao , Wang Jing , Li Jia , Jiang Yong
Published: June 2024

Eucommiae Cortex (EC) is frequently used alone or in combination with other active ingredients to treat a range of illnesses. An efficient technical instrument for changing cheap or plentiful organic chemicals into rare or costly counterparts is biotransformation. It combines EC with biotransformation techniques with the aim of producing some novel active ingredients, using different strains of bacteria that were introduced to biotransform EC in an aseptic environment. The high-quality strains were screened for identification after the fermentation broth was found using HPLC, and the primary unidentified chemicals were separated and purified in order to be structurally identified. Strain 1 was identified as Aspergillus niger and strain 2 as Actinomucor elegans; the main transformation product A was identified as pinoresinol (Pin) and B as dehydrodiconiferyl alcohol (DA). The biotransformation of EC utilizing Aspergillus niger and Actinomucor elegans is reported for the first time in this study’s conclusion, resulting in the production of Pin and DA.
Sarcopenia and Pleural Effusions: Exploring a Potential Link
Authors: Barkas Georgios I. , Karakousis Nikolaos D. , Daniil Zoe , Gourgoulianis Konstantinos I. , Kotsiou Ourania S.
Published: June 2024

Recent studies indicate a significant relationship between malnutrition, frailty, and pleural effusion (PE), highlighting the critical role of muscle mass in patient outcomes. This review investigates the association between sarcopenia—characterized by a decline in skeletal muscle mass and function—and PE, marked by fluid accumulation in the pleural space. The findings reveal that sarcopenia is prevalent in patients with PE and is linked to increased postoperative complications and mortality rates. In liver transplantation, esophagectomy, and lung cancer surgeries, sarcopenia exacerbates the risk of adverse outcomes. Notably, preoperative muscle mass assessment serves as a predictive tool for identifying patients at higher risk of complications. This review underscores the importance of early diagnosis and intervention for sarcopenia to improve clinical outcomes in PE patients. The therapeutic approach should include comprehensive nutritional evaluations and targeted muscle-strengthening interventions. By addressing sarcopenia, healthcare providers can significantly reduce PE-related complications, enhance patient recovery, and improve survival rates. This review provides a foundation for future research to develop effective strategies for the management and treatment of sarcopenia in the context of PEs, aiming to optimize patient care and quality of life.
Carrier Recombination in Nitride-Based Light-Emitting Devices: Multiphonon Processes, Excited Defects, and Disordered Heterointerfaces
Authors: Savchenko Grigorii , Shabunina Evgeniia , Chernyakov Anton , Talnishnikh Nadezhda , Ivanov Anton , Abramov Alexandr , Zakgeim Alexander , Kuchinskii Vladimir , Sokolovskii Grigorii , Averkiev Nikita , Shmidt Natalia
Published: June 2024

We study recombination processes in nitride LEDs emitting from 270 to 540 nm with EQE ranging from 4% to 70%. We found a significant correlation between the LEDs’ electro-optical properties and the degree of nanomaterial disorder (DND) in quantum wells (QWs) and heterointerfaces. DND depends on the nanoarrangement of domain structure, random alloy fluctuations, and the presence of local regions with disrupted alloy stoichiometry. The decrease in EQE values is attributed to increased DND and excited defect (ED) concentrations, which can exceed those of Shockley–Read–Hall defects. We identify two mechanisms of interaction between EDs and charge carriers that lead to a narrowing or broadening of electroluminescence spectra and increase or decrease EQE, respectively. Both mechanisms involve multiphonon carrier capture and ionization, impacting EQE reduction and efficiency droop. The losses caused by these mechanisms directly affect EQE dependencies on current density and the maximum EQE values for LEDs, regardless of the emission wavelength. Another manifestation of these mechanisms is the reversibility of LED degradation. Recombination processes vary depending on whether QWs are within or outside the space charge region of the p-n junction.
Differences in Static and Dynamic Resting-State Functional Connectivity between Migraineurs with and without Photophobia, without Phonophobia or Osmophobia
Authors: Imai Noboru , Moriya Asami , Kitamura Eiji
Published: June 2024

Background: We have previously shown that static and dynamic resting-state functional connectivity differ between migraineurs with and without photophobia, phonophobia, or osmophobia. Furthermore, some patients with photophobia also experience phonophobia or osmophobia. To investigate the functional connectivity specific to migraineurs with photophobia, we examined the differences in static and dynamic resting-state functional connectivity between patients with and without photophobia, with no phonophobia or osmophobia. Methods: Fifteen migraineurs with photophobia but without phonophobia or osmophobia, as well as 15 sex- and age-matched migraineurs without photophobia, phonophobia, or osmophobia, underwent 3-T functional magnetic resonance imaging during the interictal phase. Static and dynamic resting-state functional connectivity were compared using region-of-interest analyses of 91 cortical, 15 subcortical, and 26 cerebellar areas. Results: Static resting-state functional connectivity analysis revealed ten significant connectivity pairs in patients with photophobia, while dynamic resting-state functional connectivity analysis revealed six significant connectivity pairs in patients with photophobia. Migraineurs with photophobia had significantly lower connectivity between the cerebellar hemisphere and the temporal region than those without photophobia in both static and dynamic studies. Conclusions: Our results show that lower resting-state functional connectivity between the cerebellar hemisphere and the temporal region is specific to migraineurs with photophobia.
Metabolic Profile of Leaves and Pulp of Passiflora caerulea L. (Bulgaria) and Their Biological Activities
Authors: Gerasimova Anelia , Nikolova Krastena , Petkova Nadezhda , Ivanov Ivan , Dincheva Ivayla , Tumbarski Yulian , Yanakieva Velichka , Todorova Mina , Gentscheva Galia , Gavrilova Anna , Yotkovska Ina , Nikolova Stoyanka , Slavov Pavlo , Harbaliev Nikolay
Published: June 2024

At present, there are no data in the scientific literature on studies aimed at characterizing Passiflora caerulea L. growing in Bulgaria. The present study aimed to investigate the metabolic profile and elemental composition of the leaves and pulp of this Passiflora, as well as to evaluate the antioxidant, antimicrobial and anti-inflammatory activities of its leaf and pulp extracts. The results showed that the pulp predominantly contained the essential amino acid histidine (7.81 mg g−1), while it was absent in the leaves, with the highest concentration being tryptophan (8.30 mg g−1). Of the fatty acids, palmitoleic acid predominated both in the pulp and in the leaves. A major sterol component was β-sitosterol. Fructose (7.50%) was the predominant sugar in the pulp, while for the leaves, it was glucose—1.51%. Seven elements were identified: sodium, potassium, iron, magnesium, manganese, copper and zinc. The highest concentrations of K and Mg were in the pulp (23,946 mg kg−1 and 1890 mg kg−1) and leaves (36,179 mg kg−1 and 5064 mg kg−1). According to the DPPH, FRAP and CUPRAC methods, the highest values for antioxidant activity were found in 70% ethanolic extracts of the leaves, while for the ABTS method, the highest value was found in 50% ethanolic extracts. In the pulp, for all four methods, the highest values were determined at 50% ethanolic extracts. Regarding the antibacterial activity, the 50% ethanolic leaf extracts were more effective against the Gram-positive bacteria. At the same time, the 70% ethanolic leaf extract was more effective against Gram-negative bacteria such as Salmonella enteritidis ATCC 13076. The leaf extracts exhibited higher anti-inflammatory activity than the extracts prepared from the pulp. The obtained results revealed that P. caerulea is a plant that can be successfully applied as an active ingredient in various nutritional supplements or cosmetic products.
Genetic Engineering for Enhancing Sugarcane Tolerance to Biotic and Abiotic Stresses
Authors: Kumar Tanweer , Wang Jun-Gang , Xu Chao-Hua , Lu Xin , Mao Jun , Lin Xiu-Qin , Kong Chun-Yan , Li Chun-Jia , Li Xu-Juan , Tian Chun-Yan , Ebid Mahmoud H. M. , Liu Xin-Long , Liu Hong-Bo
Published: June 2024

Sugarcane, a vital cash crop, contributes significantly to the world’s sugar supply and raw materials for biofuel production, playing a significant role in the global sugar industry. However, sustainable productivity is severely hampered by biotic and abiotic stressors. Genetic engineering has been used to transfer useful genes into sugarcane plants to improve desirable traits and has emerged as a basic and applied research method to maintain growth and productivity under different adverse environmental conditions. However, the use of transgenic approaches remains contentious and requires rigorous experimental methods to address biosafety challenges. Clustered regularly interspaced short palindromic repeat (CRISPR) mediated genome editing technology is growing rapidly and may revolutionize sugarcane production. This review aims to explore innovative genetic engineering techniques and their successful application in developing sugarcane cultivars with enhanced resistance to biotic and abiotic stresses to produce superior sugarcane cultivars.
Exploring the Neuroprotective Potential of Desmodium Species: Insights into Radical Scavenging Capacity and Mechanisms against 6-OHDA-Induced Neurotoxicity
Authors: Chang Hung-Chi , Lien Jin-Cherng , Hsueh Min-Chung , Wu Chi-Rei
Published: June 2024

In this study, we collected seven prevalent Taiwanese Desmodium plants, including three species with synonymous characteristics, in order to assess their antioxidant phytoconstituents and radical scavenging capacities. Additionally, we compared their inhibitory activities on monoamine oxidase (MAO) and 6-hydroxydopamine (6-OHDA) auto-oxidation. Subsequently, we evaluated the neuroprotective potential of D. pulchellum on 6-OHDA-induced nerve damage in SH-SY5Y cells and delved into the underlying neuroprotective mechanisms. Among the seven Desmodium species, D. pulchellum exhibited the most robust ABTS radical scavenging capacity and relative reducing power; correspondingly, it had the highest total phenolic and phenylpropanoid contents. Meanwhile, D. motorium showcased the best hydrogen peroxide scavenging capacity and, notably, D. sequax demonstrated remarkable prowess in DPPH radical and superoxide scavenging capacity, along with selective inhibitory activity against MAO-B. Of the aforementioned species, D. pulchellum emerged as the frontrunner in inhibiting 6-OHDA auto-oxidation and conferring neuroprotection against 6-OHDA-induced neuronal damage in the SH-SY5Y cells. Furthermore, D. pulchellum effectively mitigated the increase in intracellular ROS and MDA levels through restoring the activities of the intracellular antioxidant defense system. Therefore, we suggest that D. pulchellum possesses neuroprotective effects against 6-OHDA-induced neurotoxicity due to the radical scavenging capacity of its antioxidant phytoconstituents and its ability to restore intracellular antioxidant activities.
Theoretical Expression and Screening of Real Gas Effect of Spiral Groove Dry Gas Seal
Authors: Jiang Haitao , Xu Jie , Yu Shurong , Wang Shengshun , Ding Xuexing , Jiang Andi
Published: June 2024

The emergence of dry gas seals has revolutionized the form of fluid sealing. The traditional research and analysis of dry gas seals is carried out by considering the lubricating medium gas as an ideal gas, but at this stage, the sealing application environment is complicated, so it is necessary to consider the real gas effect of the lubricating medium gas to expand and break through the design system of dry gas seals. We choose seven common lubricating media in dry gas seal applications and screen the optimal density expression of the real gas using different real gas equations of state. Then, we study the extent to which the compression factors of different lubricating gases deviate from the ideal gas and analyze the errors of different real gas equations of state. These results can provide an optimal expression to clarify the mechanism by which the real gas effect affects the dry gas seal performance, which helps to grasp the nature of dry gas seals, predict the dry gas seal behavior, and guide the dry gas seal application.
Energy-Efficient Production of Microchloropsis salina Biomass with High CO2 Fixation Yield in Open Thin-Layer Cascade Photobioreactors
Authors: Koruyucu Ayşe , Schädler Torben , Gniffke Amelie , Mundt Konrad , Krippendorf Susann , Urban Peter , Blums Karlis , Halim Billy , Brück Thomas , Weuster-Botz Dirk
Published: June 2024

Lipid production using microalgae is challenging for producing low-value-added products. Harnessing microalgae for their fast and efficient CO2 fixation capabilities may be more reasonable since algal biomass can be utilized as a precursor for various products in a biorefinery approach. This study aimed to optimize the productivity and efficiency of Microchloropsis salina biomass production in open thin-layer cascade (TLC) photobioreactors under physical simulation of suitable outdoor climate conditions, using an artificial seawater medium. Continuous operation proved to be the most suitable operating mode, allowing an average daily areal productivity of up to 27 g m−2 d−1 and CO2 fixation efficiency of up to 100%. Process transfer from 8 m2 to 50 m2 TLC photobioreactors was demonstrated, but with reduced daily areal productivity of 21 g m−2 d−1 and a reduced CO2 fixation efficiency, most probably due to increased temperatures at midday above 35 °C. An automated overnight switch-off of the circulation pumps was implemented successfully, reducing energy and freshwater requirements by ~40%. The ideal conditions for continuous production were determined to be a dilution rate of 0.150–0.225 d−1, pH of 8.5, and total alkalinity of 200–400 ppm, facilitating efficient pilot-scale production of microalgal biomass in TLC photobioreactors.
Full-Scale Demonstration of Nitrogen Removal from Mature Landfill Leachate Using a Two-Stage Partial Nitritation and Anammox Process
Authors: Du Rui , Lu Dandan , Zuo Zhiqiang , Zhang Renfu , Lu Xi , Zhu Chunshen , Hu Zhetai
Published: June 2024

The excessive discharge of nitrogen leads to water eutrophication. The partial nitritation and anammox (PN/A) process is a promising technology for biological nitrogen removal in wastewater treatment. However, applying it to mature landfill leachate (MLL) faces challenges, as the toxic substances (e.g., heavy metal) within MLL inhibit the activity of anammox bacteria. Therefore, most previous studies focused on diluted, pretreated, or chemically adjusted MLL. This study demonstrated at full scale that the two-stage PN/A process can treat raw MLL. Initially, the operational issue of sludge floatation resulted in rapid biomass loss with overflow discharging, which selectively suppresses nitrite-oxidizing bacteria (NOB), promoting the achievement of nitrite accumulation. After that, the NOB suppression was self-sustained by the high in situ free ammonia concentration, i.e., 26.2 ± 15.9 mg N/L. In the subsequent anammox tank, nitrogen removal primarily occurred via the anammox process, complemented by denitrification, achieving total nitrogen removal efficiency exceeding 72%. In addition, the nitrogen removal capacity of this system was significantly influenced by temperature with the nitrogen-loading rate above 0.4 kg N/m3/d at 38 °C and approximately 0.1 kg N/m3/d at 21 °C. The optimization of system operation, such as gradually increasing MLL content, remains necessary to enhance nitrogen removal capacity further.
Sludge-Based Superparamagnetic Nano-Sorbent Functionalized by Lanthanum Silicate Nanorods for Phosphorus Adsorption and Fertilization
Authors: Zhao Qian , Wang Xiaole , Ren Juan , Wang Wei , Xu Jingtao , Meng Shujuan , Jin Jiarou , Li Xiaochen , Fu Yuyang , Han Kechao , Mu Ruimin , Li Xinyi , Zhao Renbo , Wang Hongbo , Chen Feiyong
Published: June 2024

Phosphorus (P) recovery from wastewater is considered to be a positive human intervention towards sustainable P use in the global P cycle. This study investigated the feasibility of synthesizing a superparamagnetic nano-sorbent that was functionalized by lanthanum silicate nanorods (NRLa-Si) using drinking water treatment sludge (DWTS), evaluating both its P adsorption capacity and fertilization effect. The DWTS-based La-modified P nano-sorbent (P-sorbent D) exhibited complicated but single-layer-dominant adsorption for phosphate, with a maximum adsorption capacity up to 26.8 mg/g, which was superior to that of most of the similar sludge-based P-sorbent. The NRLa-Si-modified P-sorbent D was identified with several characterization techniques and the leaching metal elements from the nano-sorbent were tested, which were below the limits proposed by the Food and Agriculture Organization of the United Nations. In addition, the growth and vigorousness of Arabidopsis thaliana indicated that the exhausted P-sorbent D could be used as a potential water-soluble moderate-release P fertilizer, which was also confirmed by the well-fitted P uptake model and the P desorption pattern from the sorbent–fertilizer. The doped lanthanum silicate nanorods could play the dual role of P complexation enhancement and health/growth promotion. In light of this, this study proposed a new way of reclaiming DWTS as a P-sorbent for fertilization, offering new insights into the path toward “closing the P loop”.
The Hypostasis of the Archons 1–18 Revisited: The Genesis Account of the Good Creation as a Trap by the Jealous Demiurge
Authors: Poorthuis Marcel
Published: June 2024

The confrontation between Greek philosophy and the Biblical heritage has led to a wealth of different currents, varying from Christian and Jewish neo-Platonism to religious convictions that proclaim a complete rupture between creation and the highest hidden god. Although this rupture has its roots in a Platonic concept of a demiurge who as a lower divinity is supposed to be responsible for creation, in Gnosticism this chasm has been deepened to become no less than an abhorrence for embodied “material” existence, together with sheer contempt for the demiurge who is described as jealous, foolish and blind. Freeing the divine element/spark from the imprisonment in matter, an imprisonment concocted by this jealous demiurge, is the general aim of many Gnostic tracts. In the Hypostasis of the Archons, wisdom from above, surprisingly often gendered as female, but not as embodied, serves as a redeemer figure, named Sophia. This has led to an exegesis of revolt in which Eve becomes the source of this higher Wisdom, strengthened by the serpent of the Biblical story of Paradise, who likewise symbolizes this higher Wisdom.
Under the Judgement of the Living God: The Early Christian Funerary Imprecations of Phrygian Eumeneia
Authors: Doherty Bernard
Published: June 2024

Since the late nineteenth century, the Phrygian funerary imprecation, known as the Eumeneian formula, has been considered one of the clearest indicators of Christian religious identity on inscriptions from Roman Asia Minor. After a brief précis of the early scholarly history of interpretation of this formula and the historiographical assumptions which underpinned its identification as Christian, this article attempts to reframe how we understand the specific context out of which these inscriptions emerge—that of the wider socio-religious context of Roman Asia Minor—and to examine the degree of continuity which these inscriptions have in terms of religious sentiment with similar pagan examples from wider Anatolia. The central contention of this article is that the Eumeneian formula inscriptions, quite apart from what they can tell us about the socio-political status of early Christians and their relationships with their wider civic environment, are also an important index for understanding early Christian popular religion in the pre-Constantinian period and how ordinary Christians expressed their religious identity in a potentially hostile environment.
Reframing Vulnerability through an Embodied Theological Lens: Towards Ethical Engagement in a Globalized Context
Authors: Montero Orphanopoulos Carolina
Published: June 2024

This study examines the evolving concept of human vulnerability within the context of globalization and contemporary societal complexities. Its aim is to provide a comprehensive understanding of vulnerability’s proposed definition and its ethical relevance, particularly through an embodied ethical–theological lens. The research argues that this anthropological category when approached from an interdisciplinary perspective, reveals nuanced ethical dimensions essential for addressing contemporary challenges. Through the synthesis of insights from various disciplines, the study delineates the intricate interplay between corporeal experiences, affective states, and ethical considerations in understanding vulnerability. Interdisciplinary research methods were employed, drawing from theology, psychology, sociology, and philosophy. Grounding the inquiry in human experience and dialogues within different disciplinary narratives, the study explores vulnerability’s multifaceted nature and its implications for ethical engagement. The conclusions underscore the imperative role of theology in fostering ethical responses to contemporary dilemmas. By reframing vulnerability within an interdisciplinary and embodied framework, the research enriches ethical reflection and praxis, promoting human flourishing in a globalized world.
Puerariae lobatae Radix: Progress in Extraction, Separation Methods and Pharmacological Activities Research
Authors: Gao Erjian , Wang Wei , Huang Yuanyuan , Luo Zhijie , Chen Bangzheng , Xiao Siqiu , Li Dewen
Published: June 2024

Kudzu root (Puerariae lobatae Radix) is the tuberous root of Pueraria lobata, family Leguminosae. Kudzu root contains a variety of beneficial active ingredients such as puerarin, daidzin, daidzein, genistenin, 3′-hydroxy puerarin, β-sitosterol, stigmasterol, arachidic acid, and so on. Modern medical research shows that active ingredients in kudzu root are widely used clinically as raw materials for the treatment of hyperglycemia, non-alcoholic fatty liver disease, myocardial infarction, alcohol addiction, oxidative stress, inflammatory response, and retinal blockage due to their various pharmacological effects such as improving cardiovascular circulation, lowering blood lipids, lowering blood pressure, lowering blood sugar, being antipyretic, being estrogen-like, and relieving alcohol. China has rich resources of kudzu root, and active ingredients are usually extracted before it is made into a preparation, so whether the extraction and separation process is reasonable will directly affect the ease of preparation and the efficacy of the treatment. This paper reviews the process methods for the extraction and separation of active ingredients in kudzu root and its common pharmacological activities. The aim is to provide some references for readers to compare the advantages and disadvantages of various extraction and separation methods as well as understand the active ingredients and pharmacological activities of kudzu root.