bluuebunny/crossref_metadata_2025 huggingface dataset:
Collagen Prolyl Hydroxylation–Dependent Metabolic Perturbation Governs Epigenetic Remodeling and Mesenchymal Transition in Pluripotent and Cancer Cells
Authors: D'Aniello Cristina , Cermola Federica , Palamidessi Andrea , Wanderlingh Luca G. , Gagliardi Miriam , Migliaccio Agnese , Varrone Francesca , Casalino Laura , Matarazzo Maria R. , De Cesare Dario , Scita Giorgio , Patriarca Eduardo J. , Minchiotti Gabriella
Published: May 2019

Collagen prolyl hydroxylation (CPH), which is catalyzed by prolyl 4-hydroxylase (P4H), is the most prevalent posttranslational modification in humans and requires vitamin C (VitC). Here, we demonstrate that CPH acts as an epigenetic modulator of cell plasticity. Increased CPH induced global DNA/histone methylation in pluripotent stem and tumor cells and promoted cell state transition (CST). Interfering with CPH by either genetic ablation of P4H subunit alpha-2 (P4HA2) or pharmacologic treatment reverted epigenetic changes and antagonized CST. Mechanistically, we suggest that CPH modifies the epigenetic landscape by reducing VitC for DNA and histone demethylases. Repurposed drugs targeting CPH-mediated metabolic perturbation, such as the antiasthmatic budesonide, blocked metastatic dissemination of breast cancer cells in vivo by preventing mesenchymal transition. Our study provides mechanistic insights into how metabolic cues and epigenetic factors integrate to control CST and paves the way for the development of novel antimetastatic strategies.

Significance:

A phenotype-based high-throughput screening reveals unforeseen metabolic control of cell plasticity and identifies budesonide as a drug candidate for metastatic cancer.
DNA Damage Response Inhibitor Combinations Exert Synergistic Antitumor Activity in Aggressive B-Cell Lymphomas
Authors: Restelli Valentina , Lupi Monica , Chilà Rosaria , Vagni Micaela , Tarantelli Chiara , Spriano Filippo , Gaudio Eugenio , Bertoni Francesco , Damia Giovanna , Carrassa Laura
Published: May 2019

The DNA damage response (DDR) kinases ATR, Chk1, and Wee1 play vital roles in the response to replication stress and in maintaining cancer genomic stability. Inhibitors of these kinases are currently under clinical investigation. Mantle cell lymphoma (MCL) and diffuse large B-cell lymphoma (DLBCL) are aggressive lymphomas whose clinical outcome is still largely unsatisfactory. These cell lymphoma subtypes are highly dependent on both Chk1 and Wee1 for survival. We investigated the activity of the ATR inhibitor AZD6738 as single agent and in combination with either Chk1 (AZD6738) or Wee1 (AZD1775) inhibitors in several preclinical models of MCL and DLBCL. This study included preclinical in vitro activity screening on a large panel of cell lines, both as single agent and in combination, and validation experiments on in vivo models. Cellular and molecular mechanisms of the observed synergistic effect as well as pharmacodynamic analysis of in vivo samples were studied. AZD6738 exerted a strong synergistic cytotoxic effect in combination with both AZD7762 and AZD1775 in the 2 lymphoma subtypes regardless of their TP53, MYC, and ATM mutational status. These DDR inhibitor combinations, similarly to the Chk1/Wee1 inhibitor combination, caused a marked S-phase delay, with an increase in cyclin-dependent kinases (CDK) activity, increased DNA damage, and decreases in Wee1, MYC, and RRM2 protein levels. The synergistic in vitro activity translated to striking in vivo antitumor activity. DDR–DDR inhibitor combinations could potentially offer promising novel therapeutic strategies for patients with B-cell lymphoma.
RORγ Agonists Enhance the Sustained Antitumor Activity through Intrinsic Tc17 Cytotoxicity and Tc1 Recruitment
Authors: Liu Xikui , Zawidzka Elizabeth M. , Li Hongxiu , Lesch Charles A. , Dunbar Jenna , Bousley Dick , Zou Weiping , Hu Xiao , Carter Laura L.
Published: May 2019

Activation of RORγ with synthetic small-molecule agonists has been shown to enhance type 17 effector (CD4+ Th17 and CD8+ Tc17 cells) cell functions and decrease immunosuppressive mechanisms, leading to improved antitumor efficacy in adoptive cell transfer and syngeneic murine tumor models. However, whether Tc17 cells possess intrinsic cytotoxicity and the mechanism they use to lyse target cells is controversial. We report here that Tc17 cells were lytic effectors dependent on perforin and granzyme A. In contrast to Tc1 cells, Tc17 cells resisted activation-induced cell death and maintained granzyme A levels, which conferred the ability to lyse target cells in serial encounters. Thus, although the acute lytic capacity of Tc17 cells could be inferior to Tc1 cells, comparable lysis was achieved over time. In addition to direct lytic activity, Tc17 cells infiltrated early into the tumor mass, recruited other CD8+ T cells to the tumor, and enhanced the survival and lytic capability of these cells during repeated target encounters. Synthetic RORγ agonists further augmented Tc17 survival and lytic activity in vitro and in vivo, controlling tumor growth not only through direct cytotoxicity, but also through recruitment and improved function of other effector cells in the tumor microenvironment, which suggests complementary and cooperate activities for effective immunotherapy.
Epigenetic Function of TET Family, 5-Methylcytosine, and 5-Hydroxymethylcytosine in Hematologic Malignancies
Authors: Li Wei , Xu Linping
Published: May 2019

DNA methylation plays significant roles in a variety of biological and pathological processes including mammalian development, genomic imprinting, retrotransposon silencing, and X-chromosome inactivation. Recent discoveries indicated that ten-eleven translocation (TET) family of dioxygenases can convert 5-methylcytosine (5-mC) into 5-hydroxymethylcytosine (5-hmC). The TET family includes three members: TET1, TET2, and TET3. With increasing evidence, more and more biological and pathological processes in which 5-hmC and TET family serve unparalleled biological roles are noticed, for example, DNA demethylation and transcriptional regulation of different target genes, which are involved in many human diseases, especially hematologic malignancies, resembling chronic myelomonocytic leukemia, myelodysplastic syndromes, and so on. In this review, we focus on the diverse functions of TET family and the novel epigenetic marks, 5-mC and 5-hmC, in hematologic malignancies. This review will provide valuable insights into the potential targets of hematologic malignancies. Further understanding of the normal and pathological functions of TET family may provide new methods to develop novel epigenetic therapies for treating hematologic malignancies.
Anterior Thalamic Stimulation Induced Relapsing Encephalitis
Authors: Hamdi Hussein , Robin Elsa , Stahl Jean-Paul , Doche Emilie , Azulay Jean-Philippe , Chabardes Stephan , Bartolomei Fabrice , Regis Jean
Published: May 2019

Deep brain stimulation of the anterior thalamic nucleus is one of the promising therapeutic options for epilepsy. Several studies are still under way to further strengthen and clarify the mechanism, efficacy, and complications. Contrary to hardware-related and operation-related events, the stimulation-related adverse effect is mild, target-dependent, and adjustable. We present a case of relapsing herpes simplex encephalitis (HSE) as a newly reported and potentially fatal stimulation-related adverse effect following stimulation of the anterior thalamic nucleus (ANT-DBS) accompanied by fever, confusion, and cognitive impairment in a 32-year-old epileptic patient with a history of herpes meningoencephalitis 31 years earlier. The T2-weighted/FLAIR high-signal intensity in the temporal lobe developed at a “distance” from the stimulation target. The positive polymerase chain reaction of herpes virus deoxyribonucleic acid in the cerebrospinal fluid confirmed the diagnosis. The condition improved partially on acyclovir and stimulation stopped. Seizures disappeared and then returned after few months. The unique case report presents a rationale for considering history of herpes encephalitis as a relative contraindication for ANT-DBS, and HSE relapse should be suspected in patients with post-stimulation fever and/or altered consciousness.
Chromosomal Abnormalities in Patients with Intellectual Disability: A 21-Year Retrospective Study
Authors: Belkady Boutaina , Elkhattabi Lamiae , Elkarhat Zouhair , Zarouf Latifa , Razoki Lunda , Aboulfaraj Jamila , Nassereddine Sanaa , Cadi Rachida , Rouba Hassan , Barakat Abdelhamid
Published: May 2019

Background: Intellectual disability (ID) has been defined as a considerably reduced ability to understand new or complex information and to learn new skills. It is associated with life-long intellectual and adaptive functioning impairments that have a profound impact on individuals, families, and society. It affects about 3% of the general population. ID often comes out with other mental conditions like attention deficit, hyperactivity, and autism spectrum disorders (ASD), and it can be part of a malformation syndrome that affects other organs. It may be syndromic (S-ID) or non-syndromic (NS-ID). Objective: The aims of this study were to identify the profile of intellectually disable patients being referred for cytogenetic analysis in Morocco, to determine the prevalence of chromosomal abnormalities in a Moroccan group, and to compare the results with those of analogous studies from other countries. Participants: We included data from Moroccan patients with NS-ID and others with S-ID (mostly Down syndrome cases) who have been referred between 1996 and 2016. 1,626 patients were involved in this study, 1,200 were referred with a clinical diagnosis of Down syndrome, 37 were clinically diagnosed for ASD with ID, and 389 were suspected of NS-ID. Results: We identified 1,200 cases of Down syndrome. In 1,096 analyses (91.3%), a cytogenetic variant of trisomy 21 was identified: standard trisomy 21 in 1,037 cases (94.6%), a translocation in 34 cases (3.10%), and mosaicism in 25 cases (2.3%). The cytogenetic analysis among ASD with ID cases did not reveal any specific chromosomal abnormalities. The present study also shows that chromosomal abnormalities were present in 6.43% of the patients with NS-ID (25 abnormal karyotypes out of 389 NS-ID cases). Autosomal structural abnormalities were the largest proportion of chromosomal aberrations. Conclusion: The high rate of chromosomal abnormalities found in the Moroccan patients studied demonstrates the capital importance of cytogenetic evaluation in patients who show ID or any clinical development abnormality.
Erroneously High Lactate: A Guide to Diagnosing Ethylene Glycol Poisoning
Authors: Kamboj Mayanka , Bejjanki Harini , Gopal Saraswathi , Ruchi Rupam
Published: May 2019

A high lactic acid level in critically ill patients is a marker of poor prognosis. However, lactic acidosis in ethylene glycol (EG) poisoning should be interpreted cautiously as analytical interference is observed with EG metabolites.
Adsorption of Protein-Bound Uremic Toxins Using Activated Carbon through Direct Hemoperfusion in vitro
Authors: Yamamoto Suguru , Ito Toru , Sato Mami , Goto Shin , Kazama Junichiro J. , Gejyo Fumitake , Narita Ichiei
Published: May 2019

Background/Aims: Accumulation of protein-bound uremic toxins (PBUTs) is associated with mortality due to various systemic disorders in patients with chronic kidney disease (CKD), especially in those undergoing dialysis treatment. The clinical outcomes of such patients could be improved by removing sufficient amounts of PBUTs; however, conventional dialysis lacks this ability. We examined the efficacy of activated carbon in adsorbing circulating PBUTs through direct hemoperfusion (DHP) in vitro. Methods: An in vitro blood circulating system was constructed with 8.5 mL blood circulating around a column containing activated carbon (50, 100, or 200 mg). Bovine blood containing a kind of PBUT (at the same concentration as that found in the blood of dialysis patients) and blood from hemodialysis patients (n = 8) were used. After circulation for the designated amount of time, sera were collected and the levels of PBUTs, including indoxyl sulfate (IS), p-cresyl sulfate, indole acetic acid (IAA), phenyl sulfate, and hippuric acid, were analyzed with mass spectrometry. Results: Activated carbon decreased the PBUT level in bovine blood in a dose-dependent manner (e.g., reduction rate of IS: 67.9 ± 3.8, 83.3 ± 1.9, and 94.5 ± 1.1% after 60-min circulation in columns containing 50, 100, and 200 mg activated carbon respectively). IS, PCS, and IAA were dramatically adsorbed by activated carbon from the blood of patients undergoing hemodialysis (pre vs. post 240-min reaction: IS 2.835 ± 0.876 vs. 0.455 ± 0.108 mg/dL [p < 0.01], PCS 3.208 ± 2.876 vs. 0.768 ± 0.632 mg/dL [p < 0.01], IAA 0.082 ± 0.045 vs. 0.016 ± 0.005 mg/dL [p < 0.01]). Conclusion: Activated carbon effectively adsorbed blood PBUTs in vitro. DHP with activated carbon could be a promising strategy for removing circulating PBUTs from the blood of patients with CKD.
Polymorphisms of MAMLD1, SRD5A2, and AR Candidate Genes in Seven Dogs (78,XY; SRY-Positive) Affected by Hypospadias or Cryptorchidism
Authors: Krzemińska Paulina , D'Anza Emanuele , Ciotola Francesca , Paciello Orlando , Restucci Brunella , Peretti Vincenzo , Albarella Sara , Switonski Marek
Published: May 2019

Knowledge of the molecular background of disorders of sex development (DSD) in dogs with normal sets of XY chromosomes (XY DSD) is very scarce. However, extensive studies have been carried out in humans, showing that polymorphisms and mutations of numerous genes, including SRY, MAMLD1, SRD5A2, and AR, are associated with or responsible for XY DSD. In this study, we analyzed the entire coding sequence of these genes in 7 dogs (78,XY) with ambiguous external genitalia (hypospadias, cryptorchidism, bifid scrotum, or rudimentary penis). The most common disorder was hypospadias (6 cases), followed by cryptorchidism (4 cases). The co-occurrence of both abnormalities was observed in 3 dogs. Polymorphisms were found in MAMLD1 (3 SNPs), SRD5A2 (5 SNPs), and AR (2 STRs and 1 SNP), while SRY was monomorphic. However, the distribution of the polymorphic variants in the DSD dogs and 11 control XY dogs did not differ significantly. Our study suggests that an association between the polymorphisms of the studied candidate genes and hypospadias or cryptorchidism is unlikely in dogs. We thus support the recent suggestion that hypospadias is not rare in this species, and moreover, we show that co-occurrence of hypospadias and cryptorchidism can be quite frequent.
Parakinesia Brachialis Oscitans due to Brain Stem Infarct
Authors: Aaron Sanjith , Al Hashmi Amal
Published: May 2019

In stroke patients, involuntary movements can occur both in the acute and chronic phase. Here, we describe one such involuntary movement consistent with the rare phenomenon of parakinesia brachialis oscitans (PBO). PBO has been reported in ischaemic and haemorrhagic strokes involving the anterior circulation; however, this is only the second time this phenomenon is being reported in posterior circulation stroke in the English literature.
Association of Arsenic Exposure With Cardiac Geometry and Left Ventricular Function in Young Adults
Authors: Pichler Gernot , Grau-Perez Maria , Tellez-Plaza Maria , Umans Jason , Best Lyle , Cole Shelley , Goessler Walter , Francesconi Kevin , Newman Jonathan , Redon Josep , Devereux Richard , Navas-Acien Ana
Published: May 2019

Background:

Arsenic exposure has been related to numerous adverse cardiovascular outcomes. The aim of this study was to investigate the cross-sectional and prospective association between arsenic exposure with echocardiographic measures of left ventricular (LV) geometry and functioning.

Methods:

A total of 1337 young adult participants free of diabetes mellitus and cardiovascular disease were recruited from the SHFS (Strong Heart Family Study). The sum of inorganic and methylated arsenic concentrations in urine (ΣAs) at baseline was used as a biomarker of arsenic exposure. LV geometry and functioning were assessed using transthoracic echocardiography at baseline and follow-up.

Results:

Mean follow-up was 5.6 years, and median (interquartile range) of ΣAs was 4.2 (2.8–6.9) µg/g creatinine. Increased arsenic exposure was associated with prevalent LV hypertrophy, with an odds ratio (95% CI) per a 2-fold increase in ΣAs of 1.47 (1.05–2.08) in all participants and of 1.58 (1.04–2.41) among prehypertensive or hypertensive individuals. Measures of LV geometry, including LV mass index, left atrial systolic diameter, interventricular septum, and LV posterior wall thickness, were positively and significantly related to arsenic exposure. Among measures of LV functioning, stroke volume, and ejection fraction were associated with arsenic exposure.

Conclusions:

Arsenic exposure was related to an increase in LV wall thickness and LV hypertrophy in young American Indians with a low burden of cardiovascular risk factors. The relationship was stronger in participants with prehypertension or hypertension, suggesting that potential cardiotoxic effects of arsenic might be more pronounced in individuals already undergoing cardiovascular adaptive mechanisms following elevated systemic blood pressure.
Review of the cicada genus Mogannia Amyot & Serville from China, with descriptions of three new species (Hemiptera: Cicadidae)
Authors: CHEN XIAO , YANG MINGSHENG , WEI CONG
Published: May 2019

The species of Mogannia Amyot & Serville from China are reviewed. Twelve species are illustrated or photographed, including nine known species and three new species. Information on the biology and distribution are provided, and a key to all species of Mogannia from China is presented. The variation of some species of the genus Mogannia and the systematic status of the tribe Cicadatrini Distant are discussed. Morphological attributes for Mogannia indicate that it is allied to the subfamily Cicadettinae, however, we tentatively retain it in the subfamily Cicadinae, as other related genera of the Cicadatrini also need to be addressed.
Sinigarra napoense, a new genus and species of labeonin fishes (Teleostei: Cyprinidae) from Guangxi Province, South China
Authors: ZHANG E , ZHOU WEI
Published: May 2019

A new garrain genus and species are described from the Zuo-Jiang of the Zhu-Jiang (Pearl River) drainage in GuangxiProvince, South China. Sinigarra, new genus, is characterized by having the lower lip modified into a mental adhesive discposteriorly discontinuous with the mental region. It is distinguished from all other disc-bearing genera, namely Garra,Placocheilus, Discocheilus and Discogobio, by having the anterior edge of the mental adhesive disc not modified to form ananteromedian crescentic fold, an upper lip present, but separated from the upper jaw, and indistinct papillae scarcely scattered over the rostral cap and lower lip or absent.
The squat lobsters of the genus Sadayoshia Baba, 1969 (Crustacea: Decapoda: Anomura: Munididae): new records including six new species from the Pacific Ocean
Authors: MACPHERSON ENRIQUE , BABA KEIJI
Published: May 2019

Careful examination of the morphology of recently obtained specimens as well as previously reported specimens of thegenus Sadayoshia, initiated by unpublished molecular data that suggest the existence of several different species, led usto describe six new species. The species are very similar to one another and distinguished by very slight morphologicaldifferences. Some of the characters that were previously considered as intraspecifically variable in some species, proved to be valid for species discrimination. A dichotomous key to all species of the genus is provided.
The lineages of Stylocellidae (Arachnida: Opiliones: Cyphophthalmi)
Authors: CLOUSE RONALD M.
Published: May 2019

The taxonomy of the Southeast Asian mite harvestman family Stylocellidae is updated in light of new molecular and mor-phometric phylogenies, examinations of type specimens, and a new species from Thailand. A new genus, Giribetia gen.nov., is erected, and Fangensis insulanus Schwendinger & Giribet, 2005, recombined in it as Giribetia insulana newcomb. All species in the genus Stylocellus have been recombined in Miopsalis and Leptopsalis, except for the type species,S. sumatranus Westwood, 1874, and a new species, S. lornei, sp. nov., described here. The new recombinations of formerStylocellus species are as follows: Leptopsalis pangrango (Shear, 1993), new comb., Leptopsalis sedgwicki (Shear, 1979),new comb., Leptopsalis laevichelis (Roewer, 1942), new comb., Miopsalis globosa (Schwendinger & Giribet, 2004), newcomb., Miopsalis kinabalu (Shear, 1993), new comb., Miopsalis leakeyi (Shear, 1993), new comb., Miopsalis mulu(Shear, 1993), new comb., and Miopsalis pocockii (Hansen & Sørensen, 1904), new comb. “Stylocellus” spinifronsRoewer, 1942 is now designated as nomen dubium, as the sole type specimen has been found to be a juvenile. Two newsubfamilies are proposed, each with two genera: Fangensinae subfam. nov., containing Fangensis and Giribetia, and Lep-topsalinae subfam. nov., containing Leptopsalis and Miopsalis. The subfamily sensu strictu Stylocellinae contains the remaining two genera: Stylocellus and Meghalaya
literature review of the Polychaeta of the Caribbean Sea
Authors: DEAN HARLAN K.
Published: May 2019

A list of all known polychaete species reported in the primary literature is presented for the Caribbean Sea. The most spe-cies-rich polychaete faunas are those of Cuba in the North Caribbean ecoregion and Trinidad-Tobago and Colombia in theSouth Caribbean ecoregion while the ecoregion with the greatest number of species is the Greater Antilles. While part ofthe explanation for these higher diversity areas may be due to collection effort, these areas may also be higher in speciesnumber as a result of being ecotones between the Gulf of Mexico in the north and the northern South American region tothe south. The most species-rich families are the Syllidae, Eunicidae, Nereididae, Polynoidae, Sabellidae, Serpulidae, Ter-ebellidae, and Spionidae. A brief discussion of the history of polychaete research identified many of the more importantworkers in the characterization of the polychaete fauna of the region. An analysis of the species-record accumulation curvefor polychaetes indicated that this fauna has not yet been fully characterized. One portion of the polychaete fauna identified as being especially poorly known is that from the deep-water areas of the Caribbean.
New fossil Mesochrysopidae (Neuroptera) from the Mesozoic of China
Authors: YANG QIANG , MAKARKIN VLADIMIR N. , REN DONG
Published: May 2019

A new genus and two new species of extinct Mesochrysopidae (Neuroptera) are described from the Mesozoic of China:Protoaristenymphes daohugouensis sp. nov., from the Middle Jurassic of Daohugou, Inner Mongolia; and Kareninoideslii gen. et sp. nov., from the Early Cretaceous (Yixian Formation) of Dakangpu, Liaoning Province. The presence of CuPin one hind wing of K. lii gen. et sp. nov. is interpreted as an atavism. Armandochrysopa Nel et al. is regarded as a newjunior synonym of Karenina Martins-Neto. Armandochrysopa inexpecta Nel et al. is tentatively transferred to Kareninoides gen. nov.
ENSO Normals: A New U.S. Climate Normals Product Conditioned by ENSO Phase and Intensity and Accounting for Secular Trends
Authors: Arguez Anthony , Inamdar Anand , Palecki Michael A. , Schreck Carl J. , Young Alisa H.
Published: May 2019

Climate normals are traditionally calculated every decade as the average values over a period of time, often 30 years. Such an approach assumes a stationary climate, with several alternatives recently introduced to account for monotonic climate change. However, these methods fail to account for interannual climate variability [e.g., El Niño–Southern Oscillation (ENSO)] that systematically alters the background state of the climate similar to climate change. These effects and their uncertainties are well established, but they are not reflected in any readily available climate normals datasets. A new high-resolution set of normals is derived for the contiguous United States that accounts for ENSO and uses the optimal climate normal (OCN)—a 10-yr (15 yr) running average for temperature (precipitation)—to account for climate change. Anomalies are calculated by subtracting the running means and then compositing into 5 ENSO phase and intensity categories: Strong La Niña, Weak La Niña, Neutral, Weak El Niño, and Strong El Niño. Seasonal composites are produced for each of the five phases. The ENSO normals are the sum of these composites with the OCN for a given month. The result is five sets of normals, one for each phase, which users may consult with respect to anticipated ENSO outcomes. While well-established ENSO patterns are found in most cases, a distinct east–west temperature anomaly pattern emerges for Weak El Niño events. This new product can assist stakeholders in planning for a broad array of possible ENSO impacts in a changing climate.
Disenfranchised Grief and Families’ Experiences of Death After Police Contact in the United States
Authors: Baker David , Norris Dana , Cherneva Veroniki
Published: May 2019

This article examines the experiences of family members when a loved one dies after police contact in the United States. It uses qualitative data from semistructured interviews with the bereaved families of 43 U.S. citizens who died after police contact and considers their experiences as covictims of homicide. It examines how they experience grief in the aftermath of such a death and considers Doka’s concept of disenfranchised grief in evaluating how social norms affect their grieving process. It argues that individuals affected by deaths after police contact are often unable to grieve in a way that is socially legitimized. The article finds that disenfranchised grief has a racial dimension with regard to deaths after police contact with non-White families being deeply affected by it due to their position within society, the context in which their loved one died, and in terms of how the deceased was socially constructed.
How Employability Attributes Mediate the Link Between Knowledge Workers’ Career Adaptation Concerns and Their Self-Perceived Employability
Authors: Coetzee Melinde , Engelbrecht Louise
Published: May 2019

The study examines employability attributes as psychological mechanisms that explain the link between the career adaptation concerns and self-perceived employability of a sample of professionally qualified knowledge workers (N = 404). A cross-sectional survey was used to collect primary data. Results of a mediation analysis by means of structural equation modeling show that proactivity, career resilience, and career self-management attributes are significant intrinsic motivational mechanisms in explaining the link between high career adaptation concerns and high self-perceived employability. The study makes an important contribution to the employability literature by illustrating by means of self-determination theory the role of employability attributes as psychological processes that restore individuals’ sense of autonomous functioning as expressed by their self-perceived employability. The findings advance human resource management’s understanding of the role of employability attributes as mechanisms of fulfilling knowledge workers’ need for competence and autonomy in the career adaptation concerns—perceived employability link. Practice implications include supportive career development practices that strengthen knowledge workers’ sense of competence and autonomy when confronted with changes in job and employment conditions that affect their perceived employability.
Statistically Ordered: Gender, Sexual Identity, and the Metaphysics of “Normal”
Authors: Heaps Jonathan , Ormerod Neil
Published: May 2019

The recent call by Pope Francis for the church to develop a “theology of women” raises more fundamental and prior questions about the very nature of gender and sexual identity. Drawing on the metaphysics developed in Lonergan’s Insight and his heuristic structure of a scale of values found in Method in Theology, this article explores these prior questions in a way that avoids the extremes of either gender essentialism or of complete gender fluidity. It proposes a form of heteronormativity that is statistically structured allowing for a greater flexibility than suggested by gender essentialism, while still constraining the social and cultural construction of gender within certain biological realities. The authors also present Lonergan’s scale of values as a further heuristic for anticipating the force of this constraint in a differentiated way.
Relationality and Intersubjectivity within a Socially Oriented Metaphysics: A Note on Ecclesiology
Authors: Bracken Joseph A.
Published: May 2019

Given increased attention to the themes of relationality and intersubjectivity in contemporary Christian systematic theology, the author argues that these terms are best understood within the context of a new socially ordered metaphysics in which human beings enjoy a richer life through active participation in various forms of community life. He then applies this analysis to the life of the church.
Theology before the Reformation: Renaissance Humanism and Vatican II
Authors: O’Malley John W.
Published: May 2019

Histories of theology move seamlessly from late-medieval Scholasticism to the Reformation and bypass the important theological contribution of Renaissance humanists such as Lorenzo Valla and Erasmus. The article will explain the reasons for this oblivion, provide a sketch of the theological achievements of the humanists, and, most important, show how strikingly that achievement anticipated Vatican II.
A longitudinal analysis of the effect of public rail infrastructure on proximate residential property transactions
Authors: Zolnik Edmund
Published: May 2019

Value capture offers the promise of recouping the additional value that public transportation infrastructure investments confer to local property. The totality of the empirical evidence supports the contention that such investments do indeed add value to proximate residential property. However, little research to estimate just how much any additional property value changes from year to year is evident in the empirical literature. The absence of evidence on the reliability of accessibility premiums is problematic from a policy perspective because transit operators need dedicated sources of funds to compensate for the retrenchment of government sources. Adoption of a multilevel approach expands the temporal scale of analysis to more than a decade and the spatial scale of analysis to an entire heavy rail system, Metro in Washington, District of Columbia (DC), in order to estimate just how much accessibility premiums change year over year. Results advance the state of knowledge on value capture since public rail infrastructure adds property value across an entire heavy rail system, but the additional value is modest and the year-to-year changes are dramatic. Overall, a strategy to capture any additional property value to fund public transportation may technically qualify as a dedicated source of funds, but it is not a reliable source of funds.
The influence of illness duration before diagnosis on clinical characteristics and outcome in human brucellosis
Authors: Bosilkovski Mile , Siskova Dijana , Spasovska Katerina , Vidinic Ivan , Dimzova Marija
Published: May 2019

Our study assesses the influence of illness duration before establishing the diagnosis of brucellosis and initiating therapy on patients’ main clinical characteristics and outcome in an endemic area. The medical files of 297 patients with brucellosis were retrospectively analysed. They were divided into four groups according to illness duration before initiating therapy: <10 days; 11–30 days; 31–90 days; and >90 days. There were significant differences in the occurrences of fever ( P = 0.019), focal forms ( P = 0.026), spondylitis ( P = 0.034) and therapeutic failures ( P = 0.006) between the groups. Duration of >30 days before treatment initiation is responsible for more serious clinical presentation and outcome, whereas illness duration of >90 days further worsens the clinical progression in human brucellosis.
The Influence of Cochlear Implantation on Tinnitus in Patients with Single‐Sided Deafness: A Systematic Review
Authors: Peter Nicole , Liyanage Nuwan , Pfiffner Flurin , Huber Alexander , Kleinjung Tobias
Published: May 2019

Objectives

This systematic review provides an overview of the available studies (published by January 29, 2018) with descriptive data analysis about the influence of cochlear implantation on tinnitus in patients with single‐sided deafness (SSD).

Data Sources

PubMed, EMBASE, Web of Science, Cochrane Library, and Google Scholar.

Review Methods

Original studies about the influence of cochlear implantation on tinnitus, measured with different tinnitus questionnaires or visual analog scale, in patients with SSD were included. The pre‐ and postimplantation tinnitus scores of the included studies were extracted for the further systematic review.

Results

The systematic search yielded 1028 studies. After evaluating titles, abstracts, and full texts, 1011 of these were dismissed. From the remaining 17 studies, 4 showed a low directness of evidence or high risk of bias and were therefore excluded. Due to the nature of cochlear implantation in SSD, only cohort studies and no randomized trials exist, which limits the evaluation in a systematic review. Generally, the mean tinnitus questionnaire scores decreased after cochlear implantation in these 13 studies with a total of 153 patients. The most widely used tinnitus questionnaire was the Tinnitus Handicap Inventory. In these studies, 34.2% of patients demonstrated complete suppression, 53.7% an improvement, 7.3% a stable value, and 4.9% an increase of tinnitus, and none of the patients reported an induction of tinnitus.

Conclusion

This review shows a clear improvement of tinnitus complaints after cochlear implantation in patients with SSD. Therefore, tinnitus might be considered as an additional indication for cochlear implantation in SSD.
Reimagining the Iconic in New Media Art: Mobile Digital Screens and Chôra as Interactive Space
Authors: Gor Adrian
Published: May 2019

With the advancement of digital technology in contemporary art, new hybrid forms of interaction emerge that invite viewers to make images present in physical space as events that claim a life of their own. In breaking away from representational and performance art theories that have dominated the critique of new media artwork since the 1980s, this article analyses an iconic vision of mobile touchscreens based on the medieval Byzantine chorographic inscription of the sacred in profane spaces. As defined in recent art historical studies on Byzantine icons, chorography ( chôra/space + chorós/movement) builds on a multisensory spatial interaction between the beholders of icons that results in feeling the presence of a divine, invisible image. In light of postmodern critique of digital images’ capacity to manipulate notions of reality, new media aesthetic theory hardly addresses this Byzantine iconic vision that is fundamental to western visual culture. Jeffrey Shaw’s installation, The Golden Calf, is discussed to offer an alternative in understanding how digital and physical spaces function together to evoke something essentially real.
Matrices of motherhood in Judges 5
Authors: Thelle Rannfrid Irene
Published: May 2019

In Judges 5, patterns of motherhood weave throughout the poem, forming an intrinsic component of the fabric of the text. In pursuing these threads, I focus on the construction of Deborah as ‘mother in Israel’, both through this plain attribution and through the intriguing ordering of the Israelite tribes. A focus on Deborah as Israelite matriarch—a counterpart to Jacob—brings into sharp relief the counterpoint between the tribes of Deborah and the Canaanites. The imagined anxieties of the mother of Sisera serve to implicate mothers in a justification of violence against women. The poem thus prods readers/audiences to consider Israelite and their own perceptions of their enemies. The striking climax of the poem comes with the blessing for Jael and her killing of Sisera, the captain of Israel’s enemy, with the figure of Jael forming a point of triangulation in the intriguing interplay between these pivotal mothers.
Effects of curing time and de-molding temperature on the deformation of glass fiber/epoxy resin prepreg laminates fabricated by rapid hot press
Authors: Zhang Kaomin , Gu Yizhuo , Li Min , Wang Shaokai , Zhang Zuoguang
Published: May 2019

The present article focused on the residual strains and deformation of the laminates fabricated by rapid hot press process using prepreg. Strain gauges and laser tracker were utilized to measure the residual strains and deformation of the laminates. By studying the effects of curing time and de-molding temperature on residual strains and deformation of composite laminates, the efficient curing conditions were proposed and good processing quality was ensured. The results indicate that the laminates with low curing degree incline to generate high residual stresses during curing and cooling processes. The effects of cure duration and de-molding temperature on the deformation degree and type of laminates are significant. In order to ensure both curing efficiency and low deformation, the curing time of the resin and de-molding temperature should be designed cautiously. The experimental results suggest that the curing duration longer than 12 min is needed, and the de-molding temperature should be no less than 40°C lower than glass transition temperature of the cured matrix.
Firm’s Life Cycle Spurs the Dividend Payments: A Fallacy or an Actuality?
Authors: Kaur Jasminder
Published: May 2019

The study aims at testing the predictive power of life cycle proxies during the five life cycle stages in performing the accurate prognosis of dividend decisions of Indian companies. S&P BSE 500 companies have been selected for the study, and the sample period of 11 years commencing from 1 January 2005 to 31 December 2015 is taken. Life cycle of the firm is classified into five stages—introduction, growth, maturity, shake-out and decline phase. Cash flow patterns form the premise of such classification. All the four independent variables—size of company, proportion of cumulative retained profits as of total equity, total equity to total asset ratio and return on total assets (ROA)—turn out to be significant contributors in professing the occurrence of dividend payment event at the maturity stage of the firms’ life cycle.
Succession in Family Business: Sharing the Cognitive Map
Authors: Nandi Roopa , Singh Ganesh , Talib Parvaiz
Published: May 2019

Succession is the ultimate test of success reflected as sustainability in business, when managing business changes hands from a family leader to a non-family leader. This means when a family business is owned by the family but managed by a non-family member. This article explores the possibility of approaching succession process using design thinking—an approach based on appreciative inquiry. By identifying the various dimensions in which succession in family business takes place, this article introduces to business leaders a strength-based approach for creating an imagined future, that is satisfactory and acceptable after the incumbent phase out and successor phase in take place. The article emphasizes on creating of a singular image—a shared cognitive map for succession. When business leaders wilfully design a singular image, they have shared cognitive map that facilitates succession. The article provides guiding questions for design thinking in succession in family business.
Development and implementation of an effective constitutive model for architected cellular iron-based shape memory alloys: Pressure dependency and transformation-plasticity interaction
Authors: Cissé Cheikh , Zaki Wael , Ben Zineb Tarak
Published: May 2019

Using architected cellular iron-based shape memory alloys (AC Fe-SMAs) can help compensate the relatively higher density of the base material compared to NiTi-based and Cu-based shape memory alloys, while providing good shape recovery, lower production cost, and greater energy dissipation. This article is dedicated to the development of an effective and pressure-dependent constitutive model that predicts the thermomechanical response of AC Fe-SMAs. We first simulate the behavior of the cellular material using the dense model that was previously developed by the authors, along with different unit cells (UCs) subject to periodic boundary. The shape memory effect is simulated by compressing the UCs by 2% of their height, followed by mechanical unloading, and heating above the austenite finish temperature. The results highlight stress concentration, maximum phase transformation, and maximum plastic deformation at the geometry discontinuities or strands necks. Post-processing the ABAQUS ODB files with Python scripts shows that the bending-dominated unit cell with the highest maximum local values of state variables exhibits the lowest volume-averaged outputs. Comparison of the unit cell to cubic multi-cell structures points out an asymptotic vanishing of the effects of the free boundaries as the number of cells in the multi-cell structure increases. The results of the unit cells are used to calibrate the parameters of the pressure-dependent effective model. The ratios of the inelastic hydrostatic strains to the equivalent total inelastic strains indicate higher pressure effects in the bending-dominated cellular lattice than in the stretch-dominated structures. The force-displacement and “dissipated energy”-temperature curves of the cellular beam and its equivalent bulk structure obtained by simulations of 4-point bending tests are found to be close enough that the effective model can be considered as an efficient design tool for architected cellular iron-based shape memory alloy structures.
Self-Regulated Strategy Development to Teach Mathematics Problem Solving
Authors: Popham Michelle , Adams Simone , Hodge Janie
Published: May 2019

Many secondary students with specific learning disabilities (SLD) struggle with mathematics problem solving. When students with SLD are taught to use effective problem-solving strategies, their ability to solve mathematics word problems improves. The purpose of this article is to provide a guide for secondary teachers to implement self-regulated strategy development (SRSD) to teach mathematics problem-solving strategies to secondary students with SLD. The specific problem-solving strategy described in this article is SOLVE, which stands for Study the problem, Organize the facts, Line up a plan, Verify your plan with action, and Evaluate your results. Both SRSD and SOLVE are described, and an example of one teacher’s application of SRSD is shared. When taught concurrently, SRSD and SOLVE can be useful tools to help students with disabilities overcome the challenges of problem-solving in mathematics.
Challenges and Opportunities in the Estimation of Dynamic Models
Authors: Xu Ran , DeShon Richard P. , Dishop Christopher R.
Published: May 2019

Interest in modeling longitudinal processes is increasing rapidly in organizational science. Organizational scholars often employ multilevel or hierarchical linear models (HLMs) to study such processes given that longitudinal data in organizational science typically consist of observations over a relatively small number of time intervals ( T) nested within a relatively large number of units ( N; e.g., people, teams, organizations). In this paper, we first distinguish change and dynamics as common research foci when modeling longitudinal processes and then demonstrate that a unique set of inferential hazards exists when investigating change or dynamics using multilevel models. Specifically, multilevel models that include one or more time-lagged values of the dependent variable as predictors often result in substantially biased estimates of the model parameters, inflated Type I error rates, and ultimately inaccurate inference. Using Monte Carlo simulations, we investigate the bias and Type I error rates for the standard centered/uncentered hierarchical linear model (HLM) and compare them with two alternative estimation methods: the Bollen and Brand structural equation modeling (SEM) approach and the Arrelano and Bond generalized method of moments using instrumental variables (GMM-IV) approach. We find that the commonly applied hierarchical linear model performs poorly, whereas the SEM and GMM-IV approaches generally perform well, with the SEM approach yielding slightly better performance in small samples with large autoregressive effects. We recommend the Bollen and Brand SEM approach for general use when studying change or dynamics in organizational science.
Can the current hypodontia care pathway promote shared decision-making?
Authors: Barber Sophy , Pavitt Sue , Meads David , Khambay Balvinder , Bekker Hilary
Published: May 2019

Objective:

To determine the extent to which the current care pathway in hypodontia promotes shared decision-making (SDM).

Design:

Exploratory cross-sectional study using qualitative methods.

Setting:

Orthodontic department of two NHS teaching hospitals in Yorkshire.

Participants:

Young people aged 12–16 years with hypodontia of any severity and at any stage of treatment, and their parents and guardians.

Methods:

(1) Observation and audio-recording of interdisciplinary consultation in hypodontia clinics (n = 5) without any researcher interference; (2) short, structured interviews with young people with hypodontia (n = 8) and their parent (n = 8) using a topic guide to explore themes around decision-making. Audio-recordings were transcribed and analysed using a thematic framework.

Results:

Consultations were used as an opportunity for interdisciplinary discussion, information provision and treatment planning. Evidence of good communication was observed but patient engagement was low. The decision to be made was usually stated and treatment options discussed, but time constraints limited the scope for adequate information exchange and assessment of understanding. No methods were used to establish patient and family preferences or values. Interviews suggested parents expect the dental team to make decisions and young people rely on parental advocacy. Despite little evidence of SDM, participants reported satisfaction with their treatment.

Conclusions:

The current care pathway for hypodontia does not support clinicians in the steps of SDM. Recommendations for improving SDM processes include support to identify preference-based decisions, greater access to comprehensive and accessible patient information to enable preparation for consultation, alternative methods for effective communication of complex information and use of preference elicitation tools to aid value-driven decision-making.