bluuebunny/crossref_metadata_2025 huggingface dataset:
TURKISH VALIDITY AND RELIABILITY STUDY OF THE IMPACT OF DIGITAL MARKETING ON THE INTENSITY TO PURCHASE SPORTS GOODS
Authors: ERKAN Mert , KOÇAK Osman Göktuğ , YOLCU Edanur
Published: May 2023

Aim: In this study, it is aimed to adapt the “Scale of the Effect of Digital Marketing on the Intention to Purchase Sporting Goods” to Turkish language and culture. The measurement tool provides an opportunity to segment about the effects of the sales made in the field of "Digital Marketing" for individuals who provide digital marketing services and who will do research in the field of digital marketing, on the intentions of individuals to purchase sports products. Since there is no measurement tool in the Turkish literature that can evaluate the extent to which digital marketing affects the purchase intention of sports products, it is thought that this research will contribute to the field. Method: The research population consists of a total of 386 people selected by convenience sampling method from the provinces of Eskişehir and Ankara. Results: Confirmatory Factor Analysis (CFA) was used to test the structure of the scale. As a result of the analysis, it was revealed that the values of the scale were above the values given for compliance in the literature and were in a positive harmony. At the same time, the construct validity of the scale was tested. The Cronbach Alpha (0.888) internal consistency coefficient for the reliability of the scale, which consists of 4 dimensions and 15 questions, is above the values specified in the literature. Conclusion: According to the findings, it has been determined that the "Effect of Digital Marketing Scale on the Intention to Buy Sports Products" is a valid and reliable measurement tool. Therefore, it was concluded that the measurement tool, which shows the necessary psychometric properties for Turkish language and culture, can be used for event participants in Turkey.
L3 stage C. elegans dissociation for FACS isolation and RNA-seq analysis of intestine-specific cells v2
Authors: TP Williams Robert
Published: May 2023

This protocol is for generating a single cell suspension suitable for isolation of intestine-specific cells through Fluorescence Activated Cell Sorting (FACS) from L3 stage C. elegans. This protocol utilizes treatment with SDS-DTT solution and Pronase E to disrupt the cuticle. Worms are mechanically homogenized with a dounce homogenizer.
Estimating the prevalence, quality of life, economic and societal impact of arthritis in Tanzania: Protocol for a mixed methods study v1
Authors: Gad Kilonzo Kajiru
Published: May 2023

Introduction Musculoskeletal (MSK) disorders are one of the major causes of disability globally. A 2010 Global Burden of Disease study reported that MSK diseases account for 20% of all Years Lived with Disability (YLDs) in Low- and Middle-Income countries. This study will use mixed methods to generate new findings on the prevalence, quality of life, economic and societal impact of musculoskeletal disorders (including arthritis) in the Hai district in Tanzania. Methods and analysis In this mixed-methods study funded by the UK’s National Institute for Health Research (NIHR) Global Health Research Units and Groups (Award no: 17/63/35) we will conduct quantitative, community-based (urban, peri - urban and rural) and hospital based prospective surveys, supported by rapid ethnographic assessments (REAs), in-depth interviews, focus group discussions (FGDs) and clinical diagnostic screening to estimate the prevalence, economic and societal impact of arthritis. A retrospective medical records baseline review at the Kilimanjaro Christian Medical Centre (KCMC) will also be conducted to assess prevailing documentation and management of arthritis. Ethics and dissemination Ethical approval has been obtained through Kilimanjaro Christian Medical University College (KCMUCo) Research Ethics and Review committee (CRERC) in Moshi, National Health Research Ethics Committee (NatHREC) of the National Institute for Medical research (NIMR) in Tanzania and the Medical Veterinary and Life Sciences (MVLS) Ethics committee at the University of Glasgow, UK (MVLS ethics project number:20018010). We will disseminate the findings in clinical, epidemiological, and economic peer reviewed journals. Other dissemination modalities include professional conferences, short reports, community leaflets, policy briefs and dissemination events to communities and various stakeholders including the Ministry of health in Tanzania.
Qualitative methods v1
Authors: Gad Kilonzo Kajiru
Published: May 2023

This protocol details qualitative methods.
Development of the leaf forerunner tip (Vorläuferspitze) in Curio affinities (Asteraceae: Senecioneae), a structure unique to dicots
Authors:   Institute for Information Transmission Problems RAS (Kharkevich Institute), Fedotov Alexey P. ,   Lomonosov Moscow State University, Ozerova Lyudmila V. ,   Tsitsin Main Botanical Garden RAS, Timonin Alexander C. ,   Lomonosov Moscow State University
Published: May 2023

Forerunner tip, known also as Vorläuferspitze (Germ.), is a distinct usually unifacial part of a leaf which outraces all other its definitive constituents during leaf development and plays a central role in the modern models of leaf development in monocots. It is supposed to be absent in eudicots, but recent data indicate that at least genus Curio is an exception. Unlike monocots, the forerunner tips in this genus become unifacial without activity of the adaxial meristem. The scrutinized morphological and anatomical investigation revealed that precocious differentiation and unifacial structure which are widely used in identifying the forerunner tip are necessary but insufficient criteria of the structure concerned. Two additional criteria for recognition of the forerunner tip are proposed, viz. the forerunner tip takes significant part of the upper leaf zone immediately after the completion of its development and it remains distinguishable at all subsequent stages of leaf morphogenesis.
Elaboration the high mechanical strength medium for in vitro cultivation of lilacs under microgravity conditions
Authors:   Belgorod National Research University, Nikulin Ivan ,   Engineering Center NRU "BelSU", Zhuravleva Ekaterina ,   Group of companies EFKO, Tokhtar Lyudmila ,   Belgorod National Research University, Tokhtar Valeriy ,   Belgorod National Research University, Tkachenko Natalia ,   Belgorod National Research University, Voropaev Valeriy ,   Fund of Innovative Scientific Technologies,   Belgorod State Technological University named after V.G. Shukhov, Borodayeva Zhanna ,   Belgorod National Research University, Kulko Svetlana ,   Belgorod National Research University, Alfimova Nataliya ,   Belgorod State Technological University named after V.G. Shukhov, Nikulicheva Tat'yana ,   Belgorod National Research University,   Engineering Center NRU "BelSU", Titenko Aleksej ,   Engineering Center NRU "BelSU",   Fund of Innovative Scientific Technologies
Published: May 2023

In the modern world, outer space is an object of research in various fields of scientific activity. One of these spheres is plant breeding, i.e. cultivation of higher plants, as they are the most promising from the side of use as photosynthetic organisms. The use of nutrient media in which agar-agar, basalt wool, microcellulose can be used as a thickener is considered for plant life support. Also, 1.5 ml of 2-ip hormone was added to all substrates to stimulate plant growth. It was found that using agar-agar as a nutrient thickener in an amount of 15 g/l, allows the best growth and development of plants obtained by microclonal propagation under microgravity conditions. In addition, mechanical tests of nutrient media with agar-agar as a thickener determined the resistance to external factors, because the resulting substrate does not yield to indentation, deformation and fluidity.
Cogitum in the treatment of children with attention deficit hyperactivity disorder and subclinical epileptiform activity on the electroencephalogram
Authors: Bobylova M. Yu.
Published: May 2023

This article outlines the current concept of attention deficit hyperactivity disorder (ADHD) pathogenesis from the standpoint of neuroanatomy and impairments of neurotransmitter metabolism. N-acetyl-aspartate and N-acetyl-aspartyl-glutamate are crucial for ADHD development. These substances are involved in the interaction of neuronal networks, myelin maturation, and functioning of excitatory neurotransmitters (glutamatergic system). The active substance of Cogitum is a synthetic analogue of N-acetyl-aspartate. We analyzed the efficacy of Cogitum in 249 ADHD children with or without subclinical epileptiform activity on the electroencephalogram (children with cerebral palsy and epileptic seizures were excluded). Cogitum was most effective in improving attention, memory, and speech. None of the children had aggravation of epileptiform activity or developed epileptic seizures during treatment. Therefore, Cogitum is a safe drug to alleviate ADHD manifestations in children with subclinical epileptiform activity on the electroencephalogram.
Genetic heterogeneity of congenital cerebral palsy and the concept of the neurotropic genome
Authors: Sokolov P. L. , Chebanenko N. V. , Prityko A. G. , Romanov P. A.
Published: May 2023

Background. Currently, more than 500 genes are known, in one degree or another associated with the development of the phenotype of congenital cerebral palsy (CP). The amount of accumulated data requires the sorting of the mechanisms of the influence of genes on brain development.

Aim. To compare the spectrum of determinants in groups of patients with CP, accompanied (CP+) and non-accompanied (CP–) by epilepsy.

Materials and methods. 154 children with a phenotype of cerebral palsy aged from 1 to 17 years old were investigated. Boys – 92, girls – 62. Genetic mutations were confirmed by the methods of next generation sequencing (NGS) in the study of venous blood samples. Genes with anomalies were distributed to the groups of determinants for the main aspects of the development and function of the brain. A total of 13 groups were created.

Results. In the CP– group, determinants of cell dividing, brain development and cytoskeleton were identified in 11 (61.1 %) cases. In 4 (22.2 %) cases, determinants of cell metabolism and external cell membrane transport were identified. In the CP+ group in 23.5 % of cases, determinants of cell division, brain development and cytoskeleton were revealed. The number of patients with anomalies of chromatin modifications, transcription and replication processes was significantly less (4.4 %). In 42 (30.8 %), the CP+ patients found determinants of excitability of the neuronal membrane and excitation transmission. In the cases of brain malformations in both CP– and CP+ groups determinants of cellular division, brain development and cytoskeleton were identified. Interest caused cases of brain malformations with anomalies of genes of the channelopathy.

Conclusions. Our data suggests the difference between pathogenetic models CP+ and CP–. The fundamental difference of them is the presence of genes regulating the excitability of the neuronal membrane in CP+ group.
PSİKOLOJİK SERMAYENİN BİREYSEL YENİLİKÇİLİK ÜZERİNE ETKİSİ: EĞİTİM SEKTÖRÜ ÖRNEĞİ
Authors: DARICAN Şule , METE Mustafa
Published: May 2023

Psikolojik sermaye, bireysel açıdan çalışanın gelişim ve performansını arttırırken, örgütsel açıdan da çalışanın performansını geliştirerek işletmelere rekabetçi avantaj sağlamaktadır. Günümüz iş dünyasında yöneticiler, örgütlerde başarının elde edilmesinin sadece fiziksel ve finansal sermaye ile mümkün olmayacağını fark etmişlerdir. Rekabet üstünlüğü sağlamak amacıyla, insan kaynaklarının güçlü yönlerini arttırmayı ve üst düzeye çıkarmayı amaçlamakt adırlar. Diğer yandan, küreselleşmenin getirmiş olduğu yenilikler çalışanlarında yeni durumlara uyum sağlamasını zorunlu kılmaktadır. Eğitim sektörünün emek yoğun bir yapıya sahip olması, psikolojik sermaye düzeyi yüksek çalışanları bünyesinde barındırmayı avantaj haline dönüştürmektedir. Aynı zamanda, çalışanların yenilikçi düşünce yapılarıyla hareket ederek ve yenilikleri uygulayarak çalışmalarını yerine getirmeleri amaçlanmaktadır. Örgüt çalışanlarının işyerinde içinde bulundukları psikolojilerinin, işle rine karşı bakış açılarında, yeni fikirlerini ortaya koymalarının nasıl bir etken olabileceği düşünülmekte ve bu düşünce çalışmanın hareket noktasını oluşturmaktadır. Eğitim sektöründe çalışanların psikolojik sermayelerinin güçlü olması ve bunun en önemli çıktısı olan bireysel yenilikçilik eğiliminin artışı, öğrencilere yönelik verimliliğin de artışını sağlaması açısından çok önemlidir. İstanbul’da faaliyet gösteren üç özel ve dört devlet üniversitesinde eğitim veren akademisyenlerden 382 çalışana yönelik yapılan analiz sonucunda psikolojik sermayenin bireysel yenilikçiliği %69,8 pozitif yönde etkilediği belirlenmiştir. Psikolojik sermaye düzeyi arttıkça bireysel yenilikçilik düzeyinin de arttığı sonucuna ulaşılmıştır.
THE EFFECT OF INDIVIDUAL PENSION SYSTEM ON SAVINGS IN TURKEY: A QUANTILE REGRESSION ANALYSIS
Authors: BULUT Hülya
Published: May 2023

Several problems experienced in social security caused the public sector to introduce some reforms in this area and to put these new regulations into effect. The studies conducted to strengthen the system have increased the importance of individual retirement. Through the effects of the retirement conditions and financial incentives applied, the individual pension system in Turkey is increasingly gaining importance. The Individual Pension System (IPS) plays an important role in eliminating the social security-related problems with the contribution of individuals to their retirement savings and transferring resources to the financial markets by directing these individual savings to investment. In this respect, it is not possible to ignore the economic impacts of the IPS in terms of its functions both for savings and investment. This study aims to examine the relationship between savings and individual pension total assets for quarterly data between 2014 Q1 and 2019 Q4, through Bootstrap Quantile Regression due to the low number of data. As a result of the analysis, it was determined that the variable IPS has a statistically significant decreasing effect of 4.4% on savings.
Voice Recognition Systems in the Cloud Networks
Authors: Bodepudi Anusha , Reddy Manjunath , Gutlapalli Sai Srujan , Mandapuram Mounika
Published: May 2023

Voice recognition software enables computer users to use keyboards instead of only entering text using their voices. The medical and legal communities have both reported some success with speech recognition technology, even though the library literature is relatively mute on voice recognition technology. Voice-recognition technology can take over typing for someone who cannot do so due to a physical disability. Voice recognition may still be in its infancy, but it is advancing quickly and becoming more accurate, and it is well worth the investment of money, time, and effort required to learn it. Speech recognition artificial intelligence apps have seen a significant increase in numbers in recent years. Businesses increasingly rely on digital assistance and automated support to rationalize their offerings. Voice assistants, intelligent home appliances, search portals, and similar technologies are only a few instances of the widespread use of voice recognition. The research investigates the theory that one of the primary benefits of using a speech recognition system is th.at it enables the user to continue working on other tasks simultaneously. The user can direct their attention to observation and manual activities while maintaining control of the device using voice input commands. In addition, the study's findings indicate that voice recognition is an additional type of speech recognition in which a source sound is identified and matched to an individual's voice. For instance, Apple's Siri and Google's Alexa use AI-mechanized voice recognition to provide speech or text back support. On the other hand, voice-to-text programs such as Google Dictation translate words that are dictated to them as text.
Некоторые проблемы организации безопасности подозреваемых, обвиняемых и осужденных на территории следственного изолятора
Authors: Ковалев О.Г. , Чернова К.И.
Published: May 2023

В статье рассматриваются особенности организации безопасности в СИЗО УИС. Анализируется понятийный аппарат в данной области пенитенциарной теории. Отражаются проблемные вопросы в сфере обеспечения безопасности в следственных изоляторах на современном этапе развития УИС.
Разработка системы обучения и тестирования по «Информатике» на языке программирования С#
Authors: Губашева Х.А. , Базаева А.А. , Дениев А.А.
Published: May 2023

В данной статье рассматривается процесс разработки системы обучения и тестирования на языке программирования C#. В данной статье описан процесс разработки системы обучения и тестирования. Данный комплекс позволит упростить образовательный процесс, будет способствовать повышению познавательной активности школьников. Данная система предоставит широкий круг возможностей представления учебного материала (видео, звук, динамические изображения – виртуальная реальность и т.д.), интерактивность, наглядность представления материала. Данная программа предоставит обратную связь, встроенный тест обеспечит мгновенный контроль освоения материала, довольно скромный интерфейс пользователя и т.д.
Анализ возможностей современного программного обеспечения Blender по 3D моделированию
Authors: Бесхлебный В.А. , Фешина Е.В.
Published: May 2023

В статье проведен анализ возможностей программного обеспечения по 3D визуализации Blender, который может быть использован в профессиональной сфере, связанной с компьютерной графикой.
К вопросу о разработке приложения по распознаванию фильма по эпизоду
Authors: Виноградова А.Е. , Белаш В.Ю.
Published: May 2023

В статье обозначены сроки разработки и этапы создания приложения для распознавания фильма по эпизоду.
Метод координат для решения стереометрических задач с пирамидами и призмами
Authors: Полякова И.С.
Published: May 2023

В статье показано, что метод координат можно применять не только для кубов и параллелепипедов, где легко задать координатные оси, но и для призм и пирамид и находить углы и перпендикуляры. При этом координаты можно находить из соответствующих треугольников, нормали задавать как перпендикулярные вектора, координаты находить из пропорциональности. Это позволит избежать ошибок построения и неправильных ответов.
Применение лазерного излучения в медицине: обзор и перспективы
Authors: Паршина А.А. , Филиппова Е.М.
Published: May 2023

В статье рассматриваются возможности использования лазерного излучения на системы человеческого организма в диагностике, терапии, хирургии, косметологии.
Современные подходы к лечению рака онколитическими вирусами
Authors: Воробьева И. В. , Жирнов О. П.
Published: May 2023

По данным Всемирной организации здравоохранения онкологические заболевания занимают второе место по смертности в мире. Это обстоятельство является мощным стимулом для разработки новых эффективных средств лечения рака. Препараты на основе онколитических вирусов, способных избирательно уничтожать раковые клетки, являются одним из современных подходов к лечению рака. Достоинством данного метода лечения онкологических заболеваний является возможность избирательного лизиса опухолевых клеток с помощью вирусов и, как следствие, усиление противоопухолевого иммунного ответа организма, приводящего к уничтожению первичной опухоли и ее метастазов. В последнее десятилетие очевиден заметный прогресс в развитии данного метода. В настоящем обзоре мы проанализировали литературные данные по семействам вирусов, обладающих онколитическими свойствами против злокачественных новообразований различной локализации, в отношении которых был продемонстрирован положительный терапевтический эффект. Мы также рассмотрели главные механизмы онколитического действия вирусов и оценили преимущества использования вирусов перед другими методами терапии рака и перспективы их применения в клинической практике.
A COMUNICAÇÃO EFETIVA NO ALCANCE DE PRÁTICAS SEGURAS: CONCEPÇÕES E PRÁTICAS
Authors: Castro Juliana de Viana Rodrigues , Amaro Marilane de Oliveira Fani , Mendonça Érica Toledo , Siman Andréia Guerra , Zanelli Fernando Pacheco , Carvalho Camilo Amaro de
Published: May 2023

Objetivo: Analisar as ações realizadas e os desafios da equipe de enfermagem para alcançar a meta de segurança de comunicação efetiva em um centro cirúrgico de um hospital de ensino. Método: Estudo de caso com abordagem qualitativa, realizado com a equipe de enfermagem nos meses de janeiro e fevereiro de 2019. A coleta de dados ocorreu através de entrevistas com roteiro semiestruturado, tendo sido submetidas a análise de conteúdo. Resultados: Evidenciaram-se três categorias temáticas:  Comunicação na concepção da equipe de enfermagem: importância e instrumentos utilizados; Comunicação efetiva: desafios vivenciados e repercussões na assistência de enfermagem; Benefícios da comunicação entre profissional de saúde e paciente: construindo vínculo e confiança. Conclusões: Foram identificados alguns desafios como ausência de reuniões, falta de escuta qualificada e sobrecarga de trabalho, os quais podem favorecer a ocorrência de erros, interferindo, na segurança do paciente. Urge a necessidade de sistematizar o processo de comunicação no local pesquisado.
Análisis sensorial, textural y actividad antioxidante de queso añejo de Zacazonapan durante la maduración
Authors: Torres-Salas Verenice , Hernández-Montes Arturo , Hernández-Rodríguez Blanca E.
Published: May 2023

La proteólisis durante la maduración de los quesos contribuye a la generación de biopéptidos, y a cambios en las características sensoriales y texturales. El objetivo de este trabajo fue determinar la capacidad antioxidante, así como los cambios en las características sensoriales y texturales del queso añejo de Zacazonapan, durante la maduración (0, 30, 95 y 180 d). A los 95 días los extractos de los quesos evaluados presentaron el mayor contenido de proteína soluble. El grado de hidrólisis de proteínas obtenido a los 95 y 180 días de maduración fue 7.43 ± 0.34 y 6.44 ± 0.31 %, respectivamente. La captación del radical libre DPPH fue mayor a los 30 y 180 días (18.70 ± 0.48 y 19.92 ± 0.48 %, respectivamente), mientras que la mayor capacidad de absorción de radicales de oxígeno (ORAC) se registró a los 180 días. Con respecto a las características sensoriales, los quesos con 180 días presentaron atributos como sabor residual amargo, olor a pies, dureza, pungencia, sabor a queso madurado y apariencia porosa; además de una textura dura y baja elasticidad.
Fiziološka in mikrobna stabilnost pridelka
Authors: Unuk Tatjana
Published: May 2023

Pri poskusu ugajanja potrošnikom, v njihovi želji po visokokakovostni hrani brez ostankov FFS, ob pridelavi na trajnostni/sonaravni način in upoštevanju vseh strogih okoljskih zahtev, je sadjar velikokrat postavljen v izjemno težek položaj. Različni zorni koti pri determiniranju kakovosti z vidika sadjarja, potrošnika, hladilničarja in trgovca, ne poenostavijo situacije. Zaradi pridelovalnih sistemov, kjer veljajo zelo stroge omejitve uporabe FFS (oz. sintetičnih FFS), se velikokrat rizik, ki se pojavi predvsem zaradi mikrobne nestabilnosti plodov, prenese iz nasada v hladilnico. Izrazite spremembe okoljskih dejavnikov, med katerimi delno obvladujemo le vodo, postavljajo sadjarja v položaj, ko mora bolj, kot kadarkoli prej, s fiziološkega stališča razumeti vplive okoljskih stresnih dejavnikov. Slednji so ekstremne nizke temperature, sušni stresi, stresi zaradi visokih temperatur, močno sončno sevanje, močni vetrovi, spremenjen režim padavin itd. Obvladovanje pridelave z upoštevanjem vsega, kar doprinese okolje, terja od sadjarja močno prilagajanje in prav tako veliko znanja. Tako, kot sadjar, pa se mora prilagajati hladilničar. Poznavanje zrelostnega stanja plodov ob vskladiščenju je bistveno preskromen podatek, na osnovi katerega se pridelek umešča v različne programe skladiščenja. Za uspeh v poobiralnih tehnologijah mora hladilničar poznati zgodovino nasada, vodni in prehranski program ter program uravnavanja oveska.
Spravilo pridelka jabolk
Authors: Tojnko Stanislav
Published: May 2023

V okviru projekta visokostorilna trajnostna pridelava jabolk je zajeta tematika spravila pridelka, ki se osredotoča predvsem na izhodišča za praktično uvajanje strojev s ciljem povečanja storilnosti obiranja. Glede na izhodiščne pogoje sadjarskega obrata se pridelovalci poslužujejo različnih tehnologij spravila pridelka, kar izhaja iz izjemno različnih pridelovalnih pogojev, ki smo jih priča v Sloveniji. Prispevek opisuje različne pristope k organizaciji obiranja, uporabi opreme in strojev za povečanje učinkovitosti ter navodila k načrtovanju in organizaciji spravila ob hkratnem upoštevanju tehnoloških zahtev in obiralnih oken.
Stability of a rod with the elastic joint exposed to distributed non-conservative load
Authors: Radin V.P. , Chirkov V.P. , Poznyak E.V. , Novikova O.V.
Published: May 2023

Numerous features of non-conservative mechanical systems identified in studying their stability determine significant theoretical and practical interest to analyze various options of the calculation schemes. The paper considers stability of a rectilinear rod connected at one end to a joint and loaded with follower and potential loads uniformly distributed along the rod length. The joint was rigid with respect to rotation of the rod end. In order to apply the method of expanding solution to the perturbed motion equation into a series in terms of eigenmodes, the problem of determining the system eigenfrequencies and modes was solved. The cases of separate and combined action of the follower and potential loads were considered. A study was made on the influence of rigidity of the rod fastening and damping in the system on the loads critical values and on the position of the stability region boundaries on the loading parameters plane.
Pneumoelectric controllers based on the jet force action effect
Authors: Makarov V.A. , Kazaryan A.Z. , Korolev F.A.
Published: May 2023

The paper considers issues of design and development of pneumoelectric controllers based on compensation of the jet power action pneumatic moment by the magnetoelectric moment. The main controller elements include magnetoelectric galvanometer, sensitive element (flat plate), as well as pneumatic, optical and electrical circuits. Pneumoelectric controllers are characterized by high sensitivity and speed. Schemes of inkjet-photocompensation proportional, proportional-integral, proportional-integral-differential, semi-proportional controllers and of the preliminary and differentiation units are provided.
«Entre nosotros nos estamos acabando» : cosmohistoria siekopai (airo pai/secoya) de las epidemias y los apetitos
Authors: Belaunde Luisa Elvira
Published: May 2023

Siempre generoso y paciente conmigo, Liberato me dijo que trajera mi grabadora para contarme una historia de los antiguos, aipë cocua, sobre el origen de la muerte por enfermedad. Estas, me explicó tenían un momento inicial y, por tanto, tal vez también podían tener un final. Su relato, transcrito arriba, comenzó con la afirmación de la conciencia de las epidemias como fenómenos de enfermedad y muerte colectivos que se iniciaron en un momento en el tiempo histórico. Las formas de muerte preexistentes a las epidemias eran individuales, sucedían en momentos diferentes y a consecuencia de hechos observables, como la caída de un árbol, un corte o la picadura de una serpiente. La muerte por enfermedad, al contrario, comienza con un acontecimiento que involucra a un grupo de manera simultánea, y afecta a todas las generaciones dentro de dicho grupo, desde los más viejos hasta los más jóvenes.
Memorias de contagio : estrategias yáneshas ante la COVID-19 y otras epidemias
Authors: Santos Granero Fernando
Published: May 2023

El 7 de abril de 2020, los habitantes de la comunidad yánesha San Pedro de Pichanaz (distrito de Palcazu, provincia de Oxapampa, departamento de Pasco) decidieron cerrar la carretera que comunica Lima con Puerto Bermúdez, Ciudad Constitución y Pucallpa, con el fin de impedir el ingreso de la pandemia causada por el virus SARS-CoV-2 a la región (Municipalidad Distrital de Pacalzu, 2020c). La noticia saltó a los medios nacionales de comunicación una semana más tarde (Radio América, 2020).
«Hojas para bañar, hojas para emplastar y raíces para chupar» : epidemias, crisis económicas y estrategias yáneshas en la comunidad nativa Tsachopen
Authors: Ortiz Eduardo
Published: May 2023

Los pueblos indígenas han experimentado diferentes epidemias a lo largo de su historia. En el caso del pueblo yánesha recurrieron al aislamiento y al uso de plantas medicinales para curarse y prevenir otros brotes. En este breve artículo queremos aproximarnos a la experiencia de dos pobladores yánesha de la comunidad nativa de Tsachopen a partir de nuestra conversación el 17 de mayo de 2020.
Humos, aires y olores patógenos : apuntes para una epidemiología mastanawa
Authors: Rolando Giancarlo
Published: May 2023

Este texto tiene el doble objetivo de acercarnos, en la medida de lo posible, a la experiencia vivida por los mastanawa durante estos años de epidemias, así como a su comprensión de las mismas. Con esta finalidad, en la siguiente sección, en la cual describo algunas de las memorias de los ancianos mastanawa, intercalo mis palabras con fragmentos de las narraciones de algunos de los protagonistas de estas memorias que encontré durante mi trabajo de campo en el Alto Purús. En la tercera sección, me centro en el análisis de los humos, aires y olores patógenos que los mastanawa asocian a los brotes de enfermedades epidémicas ocurridos desde la época en que establecieron relaciones permanentes con la sociedad de la frontera peruano-brasileña hasta la pandemia de la COVID19, en curso mientras escribo este texto.
Epidemias y formación de comunidades entre los harakbut
Authors: Pinedo Danny
Published: May 2023

Tras ser contactados por misioneros y buscadores de oro en la década de 1940, los harakbut sufrieron epidemias de enfermedades nuevas que diezmaron su población y quedaron al borde del exterminio. Los brotes epidémicos estuvieron ligados no solo a los primeros contactos sino también a la posterior concentración de los harakbut en misiones, donde el nuevo patrón de asentamiento facilitó la transmisión de enfermedades. Sin embargo, los harakbut lograron superar las epidemias y con el paso de los años su población se recuperó. En este texto sostengo que la recuperación demográfica del pueblo harakbut dependió en gran medida de la formación de nuevos asentamientos, los que más tarde jugarían también un papel central en la defensa de sus territorios.
Determination of In vitro Nutrient Digestibility of Silage based Diets with Varying Levels of Crude Fibre using Pig Faecal Inoculum
Authors: Barman K. C. , Barman K. , Verma A. K. , Jadhav S. E. , Dutta N. , Singh P. , . P.Chaudhary , Jat S. L.
Published: May 2023

Background: The in-vitro nutrient digestibility and fermentation mimicking gastrointestinal process of pigs is a convenient method for rapid and cheaper measurement of degradation of feed ingredients. In the present study silage based diets containing varying levels of crude fibre were subjected to in vitro digestibility evaluation using pig faecal inoculum to determine the best crude fibre level for feeding pigs. Methods: Eight diets were prepared namely, B1, B2, V1, V2, V3, M1, M2 and M3 having 6.28, 8.43, 8.03, 10.0, 11.96, 8.17, 10.31 and 12.06 per cent crude fibre (on dry matter basis) respectively, where diets B1 and B2 were basal diets, V1, V2 and V3 contained vegetable waste silage; M1, M2 and M3 contained maize silage -as additional fibre source. An in-vitro study was carried out to investigate the nutrient digestibility of diets involving enzymatic hydrolysis and fermentation using pig faecal inoculum. Result: The in-vitro total tract digestibility (IVTTD) of dry matter (DM), crude protein (CP) and organic matter (OM) was significantly higher (P less than 0.001) in B1 diet than the other diets. The digestibility of DM, CP and OM of B2 diet was also significantly higher (p less than 0.001) than the M2, M3, V2 and V3 diets but comparable to M1 and V1 diets. The IVTTD of crude fibre (CF) was higher in V3 diet (25.85%) and lowest (P less than 0.001) in M1 diet (11.65%) and both showed a highly significant (P less than 0.001) difference (to other diets. The DM, CP and OM digestibility were significantly higher (P less than 0.001) in the diets containing normal fibre sources than silage containing diets. Cumulative gas production (ml/0.5g feed) at 24 h of in-vitro fermentation were significantly higher (P less than 0.001) in B2 (34.95) and B1 (31.00) diets than other diets. As the CF level in diets increased from 6 to 12%, the digestibility of nutrients linearly decreased except CF digestibility. It was revealed from the study that the level and sources of crude fibre in diets influenced the digestibility of nutrients.
Induced Mutagenesis and Variability Study in the M2 Generation of Garden Pea (Pisum sativum L.)
Authors: Vasanthrao Thalari , Sarma Debojit , Barua P. K. , Sharma K. K. , Kalita P. , Gogoi S.
Published: May 2023

Background: Mutation induction in garden pea (Pisum sativum L.) aimed to study the induced genetic variability and identify desirable mutants in the M2 generation with two varieties of garden pea, Kashi Nandini and Kashi Uday. Methods: The two varieties of garden peas, Kashi Nandini and Kashi Uday, were subjected to mutagenic treatments with the EMS at 0.05, 0.10, 0.15, 0.20, 0.30 and 0.40%. The M1 generation was raised in RBD with two replications during Rabi 2019-20. Plants from three concentrations, 0.10, 0.15 and 0.20% EMS, were evaluated in M1 plant progenies (M2) during Rabi 2020-21. The M2 was raised during Rabi 2020-21 in M1 plant progenies using M1 plants from three concentrations -0.10, 0.15 and 0.20% EMS of both varieties. Result: The two varieties that were exposed to EMS responded differently depending on the concentrations. The GCV and PCV were high for seedling height, fertile branches, pods/plant and seeds/pod in both parents at 0.15 and 0.20% EMS. The highest heritability and genetic advance were apparent for seedling height and seeds/pod at 0.10 and 0.20% EMS, while the estimates were moderate for seeds/pod with 0.20% EMS, followed by seeds/pod at 0.10% EMS and seedling height at 0.20% EMS. Desirable plants were visible for various quantitative traits in the M2 generation. These mutants showed significant differences from the controls of both varieties in the treated populations at higher concentrations of EMS. Desirable micro mutants in M2 resulted at 0.15 and 0.20% EMS, which need further evaluation in the M3 for confirmation.
LEPIDOPTERA TORTRICIDAE FROM THE SILA MASSIF AND SURROUNDING TERRITORY (SOUTHERN ITALY) WITH DESCRIPTION OF ACLERIS SILANA SP. N.
Authors: TREMATERRA PASQUALE , SCALERCIO STEFANO , FUMO FEDERICA , COLACCI MARCO
Published: May 2023

In the paper 89 species of Lepidoptera Tortricidae collected in the Sila Massif and surrounding territory (Calabria, southern Italy) are listed. Acleris silana sp. n. Trematerra is described and 17 species were added to the Calabrian fauna. Notes related to tortricid fauna of the region with biogeographic study and chorological analysis are also reported. Key Words: Lepidoptera Tortricidae, fauna, Calabria, new data, Sila Massif, southern Italy
Exuberant Plexiform Neurofibroma
Authors: Correia Catarina , Reis Miguel , Filipe Paulo
Published: May 2023

N/a.
Immediate and Medium-Term Results of Aortic Valve Replacement With Biological Prosthesis in Elderly Patients: One Center’s Experience
Authors: Kadyraliev Bakytbek , Belov Vyacheslav , Marchenko Andrey , Arutunyan Vagram , Engioev Soslan , Zhigalov Konstantin , Musaev Orhan , Kdralieva Nurslu , Kuchumov Alex G.
Published: May 2023

Currently, aortic valve (AV) disease is the most common reason for heart valve surgery. The gold standard of care for people with aortic pathology is thought to be AV replacement. The issue of prosthesis selection has always been important. Although mechanical prosthesis are robust, lifelong anticoagulation medication is necessary due to the significant risk of thromboembolic consequences. Biological prostheses have a flow structure that is similar to the physiological one, and as malfunction gradually sets in, scheduled recurrent surgery can be carried out. The purpose of this study is to evaluate the short- and long-term effects of biological prosthetic aortic valve replacement (AVR) in elderly individuals. The study included 198 patients with AV pathology [85 men (42.9%)/113 women (57.1%)]. The median age was 70 [66–73] years. There were 175 (88.4%) patients with degenerative AV, 5 (2.5%) with infective endocarditis, and 30 patients (15.2%) had bicuspid AV. The median follow-up period was 26.3±1.4 months. Hospital mortality was 4.5%. No wound complications were detected. Thirty-one patients died in the long-term period. The causes of lethality were: cardiovascular disease (13 patients), malignant neoplasm (5 patients), gastrointestinal disease (2 patients), urinary system disease (1 patient), COVID-19 (1 patient), unknown cause (9 patients). Thus, the five-year postoperative survival rate was 63%, respectively. Throughout the observation period, two patients (2.9%) underwent reoperation on AV. 97.1% of patients were free of reoperation after five years. The five-year survival rate was 63% due to the history of severe concomitant pathology and mean age of the patients of 70 years.
Microstructure of Bio-Based Building Materials: New Insights Into the Hysteresis Phenomenon and Its Consequences
Authors: Latapie Séverine Rosa , Abou-Chakra Ariane , Vincent Sabathier
Published: May 2023

Considering the current energy environment, both efficient and environmentally friendly solutions have to be developed for building construction. Bio-based building materials offer new perspectives through their insulating and natural humidity regulation capacities. Nevertheless, these materials are as complex as they are promising and grey areas still remain regarding their behavior. Their water sorption and desorption curves recorded in experimental work demonstrate a hysteresis phenomenon and, although plausible hypotheses have been formulated in the literature, there is currently no consensus on its causes. Furthermore, it is important to emphasize that no reference considers the hydrophilic nature of the resource. Yet this is a specificity of raw material coming from the plant world. In this context, this paper explores the microstructure and chemical composition of plant aggregates to propose a new explanation for the hysteresis. It is based on recent work demonstrating the existence of differentiated hydrogen bonds between the water sorption and desorption phase in cellulose. Obviously, hysteresis also has an origin at the molecular scale. Lastly, the hypothesis put forward here is supported by the swelling of bio-based materials that has been observed at high relative humidity and this study aims to identify a link between the mechanical (swelling/shrinking) of bio-based materials and their hygroscopic behavior. This leads to a better understanding of the hydro-mechanical coupling of these materials.
In vivo bone progression in and around lattice implants additively manufactured with a new titanium alloy
Authors: Obaton Anne-Françoise , Fain Jacques , Meinel Dietmar , Tsamos Athanasios , Léonard Fabien , Lecuelle Benoît , Djemaï Madjid
Published: May 2023

The osseointegration process in and around additively manufactured (AM) lattice structures of a new titanium alloy, Ti–19Nb–14Zr, was evaluated. Three different implants, including lattices with increasing high sidewalls gradually closing them, were designed, manufactured and implanted in the tibia and metatarsal bone of two sheep for twelve weeks. After removal, they were characterized with X-ray computed tomography (XCT). The 3D XCT images were segmented using machine learning. The bone-interface implant (BII) and bone-implant contact (BIC) were studied. The results show that, since AM naturally leads to high roughness surface finish, the wettability of the implant is increased. The new alloy possesses an increased affinity to the bone enhancing the quality of osseointegration. The lattice provides crevices, in which the biological tissue can jump in and cling. The combination of these factors is pushing ossification beyond its natural limits. Therefore, the quality and speed of the ossification and osseointegration in and around these Ti–19Nb–14Zr AM laterally closed lattice implants open the possibility of bone spline key of prostheses. This enables the stabilization of the implant into the bone while keeping the possibility of punctual hooks allowing the implant to be removed more easily if required.
From Innovation to Implementation: The Evolution of HIV Pre-exposure Prophylaxis and Future Implications
Authors: Rosas Cancio-Suárez Marta , Díaz-Álvarez Jorge , Ron Raquel , Martínez-Sanz Javier , Serrano-Villar Sergio , Moreno Santiago , Sánchez-Conde Matilde
Published: May 2023

Pre-exposure prophylaxis (PrEP) is a highly effective HIV prevention strategy that involves the continuous administration of antiretroviral drugs to HIV-negative individuals wit a substantial risk of contracting an HIV infection. The use of PrEP has shown a reduction in the risk of HIV acquisition through sexual intercourse by up to 99%. Despite its effectiveness, PrEP uptake remains low among populations at high risk of HIV infection. This highlights the need for further research in stratetegies to enhance awareness and uptake of PrEP amongst these specific populations
Heat Shock Proteins Mediate Intercellular Communications within Tumor Microenvironment Cells through Extracellular Vesicles
Authors: Saito Renata F. , Rangel Maria Cristina , Otake Andreia Hanada , Machado Camila Maria Longo
Published: May 2023

Considering tumors from an evolucionary perspective, successive tumor cells undergo turnover in response to stressful conditions which pressures tumor cells to adapt to a new environment. Tumor cells uses parts of themselves to communicate and share biological information, known as extracellular vesicles (EV) secretion to promote their survival and “survive to each and every metabolic cost”. Tumor microenvironment (TME) is a miscellaneous of cells, factors, extracellular matrix proteins and EVs. EVs include smalls (<160nm, exosomes) and larger (100-1,000nm, microvesicles) lipid bilayer enclosed packages of biomolecules that are shed by tumors to TME. Tumor-derived extracellular vesicles transfer adaptative stress signaling to recipient cells, reprograming these cells. Heat Shock Proteins (HSP) are more prominent stress response regulators found in exosomes. HSP-loaded exosomes actively reprogram tumor and TME cells to acquire mechanisms that contribute to tumor progression and therapy resistance. The intercellular communication mediated by HSP-loaded EVs favors the escape of tumor cells from, endoplasmic reticulum (ER) stress, hypoxia, apoptosis and anti-cancer therapies. Extracellular HSPs activate and deactivate immune response, induce cell differentiation, changes vascular homeostasis, and help to augment the pre-metastatic niche formation. Here we will explore the EV mechanism of HSP transmission among TME cells and the relevance of these intercellular communications for resistance to therapies in cancer.
Maximizing Energy Efficiency and Daylight Performance in Office Buildings in BIM through RBFOpt Model-Based Optimization: The GENIUS Project
Authors: Ratajczak Julia , Siegele Dietmar , Niederwieser Elias
Published: May 2023

Advancements in Parametric Design, Generative Design, and automation in Building Information Modelling (BIM) have opened new opportunities for architects and engineers working on complex buildings, such as offices. These developments allow designers to enhance their designs, increase project efficiency, improve performance, and reduce project time and costs. To address conflicting objectives that arise during the design process, genetic algorithms with multi-objective optimization (MOO) have been employed in architectural design. The GENIUS project aims to optimize building shape, apertures, and shading systems in the concept and design stages, with a focus on energy and daylight performance. The project integrates BIM and visual programming tools with Artificial Intelligence techniques like Genetic Algorithms and RBFOpt model-based optimization. Optimization algorithms are used to identify the best solutions that meet all design objectives, helping architects optimize their designs and achieve desired outcomes. The workflow was tested on a case study of a large office building, with MOO focused on maximizing daylight performance using Spatial Daylight Autonomy metric and minimizing energy consumption using Energy Use Intensity metric. The project provides architects with a method to improve their designs using Algorithm Aided Design tools, which help identify the best solutions for complex design problems.
Peripheral Nerve Ultrasound for the Differentiation between ALS, Inflammatory and Hereditary Polyneuropathies
Authors: Hildebrand Annkatrin , Schreiber Frank , Weber Luisa , Arndt Philipp , Garz Cornelia , Petri Susanne , Prudlo Johannes , Meuth Sven G. , Waerzeggers Yannic , Henneicke Solveig , Vielhaber Stefan , Schreiber Stefanie
Published: May 2023

Background and Objectives: Ultrasound (US) is a non-invasive tool for the in-vivo detection of peripheral nerve alterations. Materials and Methods: In this study we applied nerve US to assist the discrimination between the spectrum of Amyotrophic Lateral Sclerosis (ALS, n=11), chronic inflammatory demyelinating polyradiculoneuropathy (CIDP, n=5) and genetically confirmed Charcot-Marie-Tooth disease (CMT, n=5). All participants and n=15 controls without neurological diseases underwent high-resolution US of the bilateral tibial nerve. Nerve cross-sectional area (CSA) and nerve microvascular blood flow were compared between the groups and related to cerebrospinal fluid (CSF) measures, clinical symptoms and nerve conduction studies. Analyses are part of a larger multimodal study on the comparison between US and 7 Tesla (T) magnetic resonance neurography (MRN). Results: Patients and controls were matched with respect to their demographical data. CMT had the longest disease duration, followed by CIDP and ALS. CSA was related to age, weight and disease duration. CSA was larger in CMT and CIDP compared to ALS and controls. Blood flow was greatest in CIDP, and higher than in CMT, ALS and controls. In ALS, greater CSA was correlated with greater CSF total protein and higher albumin quotient. US measures did not correlate with clinical scores or nerve conduction studies in any of the subgroups. Conclusion: Our results point towards the feasibility of CSA and blood flow to discriminate between ALS, CIDP and CMT, even in small sample sized groups. In ALS, larger CSA could indicate an inflammatory disease subtype characterized by reduced blood-nerve barrier integrity. Our upcoming analysis will focus on the additive value of 7T MRN in combination with US to disentangle the spectrum between more inflammatory or more degenerative disease variants along the disease groups.
Image E-book Guidance for Improving Urinary Catheter Discomfort, Self-Efficacy, and Pain in Postoperative Patients
Authors: Huang Hsin-Shu , Fang Hsin-Yuan
Published: May 2023

This research used an experimental study design in which 60 subjects were randomly assigned to either an experimental (image e-book guidance) group or a control (text guidance) group after meeting the admission conditions and agreeing to participate in the study. It was proven that providing image e-book guidance before surgery significantly changed the behavior of patients and promoted relief of urinary catheter discomfort through self-efficacy to reduce urinary catheter pain after surgery. It was found that providing image e-book guidance can shorten the time for health education and provide patients with repeated medical education and familiarity with health guidance, which can help to address the important clinical service demand issue and the shortage of nursing staff.