bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis of axially silicon phthalocyanine substituted with bis- (3,4-dimethoxyphenethoxy) groups and energy features, charge density analysis and molecular docking studies
Authors: Solgun Derya Gungordu , Tanriverdi Aslihan Aycan , Yildiko Umit , Ağırtaş Mehmet Salih
Published: August 2022

Axially bis-substituted silicon phthalocyanine was synthesized from the reaction of 2-(3,4-dimethoxy phenyl) ethanol and SiPcCl2. The structure of the compound was justified by FT-IR, 1H NMR, 13C NMR, UV-Vis, and mass spectra. The conglomeration action of the phthalocyanine compound was determined by UV-visible spectra at different concentrations and in different solvents. Some parameters of this axial silicon phthalocyanine compound were investigated by computational chemistry. Structural optimization of axial silicon phthalocyanine substituted with compound, HOMO-LUMO energies and MEP maps was performed by density functional theory (DFT) studies. In addition, a chemical bond analysis of the molecule was performed with quantum theory atom in molecules (QTAIM). Finally, a molecular docking study was applied to this new phthalocyanine molecule in its binding mechanism.
Bayesian deep learning for error estimation in the analysis of
anomalous diffusion
Authors: Seckler Henrik , Metzler Ralf
Published: August 2022

Modern single-particle-tracking techniques produce extensive time-series of diffusive motion in a wide variety of systems, from single-molecule motion in living-cells to movement ecology. The quest is to decipher the physical mechanisms encoded in the data and thus to better understand the probed systems. We here augment recently proposed machine-learning techniques for decoding anomalous-diffusion data to include an uncertainty estimate in addition to the predicted output. To avoid the Black-Box-Problem a Bayesian-Deep-Learning technique named Stochastic-Weight-Averaging-Gaussian is used to train models for both the classification of the diffusion model and the regression of the anomalous diffusion exponent of single-particle-trajectories. Evaluating their performance, we find that these models can achieve a well-calibrated error estimate while maintaining high prediction accuracies. In the analysis of the output uncertainty predictions we relate these to properties of the underlying diffusion models, thus providing insights into the learning process of the machine and the relevance of the output.
Are platelet concentrate scaffolds superior to traditional blood clot scaffolds in regeneration therapy? A systematic review and meta-analysis
Authors: Tang Qianwei , Jin Hua , Lin Song , Ma Long , Tian Tingyu , Qin Xiurong
Published: August 2022

Background
The effectiveness of platelet concentrates in promoting root development of necrotic immature permanent teeth is unclear. The present study evaluated whether the platelet concentrate protocol was superior to the traditional blood clot protocol in regeneration therapy.
Methods
Electronic databases, such as PubMed, Cochrane Library, ClinicalTrials and EMBASE, were searched for studies comparing these protocols, with identified studies manually searched for relevant references. Clinical case-control studies were included, in which platelet-rich concentrates were tested for pulp regeneration and radicular development, with the blood clot treatment protocol as the control group. Clinical and radiographic outcomes were considered.Selected articles were assessed for risk of bias. Pooled Risk ratios were calculated for clinical success, responses to cold and electric pulp tests, periapical lesions, apex closure, root lengthening, and thickening of the dentin walls. Heterogeneity was assessed using I2 statistics and Cochrane’s Q test.
Results
Of the 1272 screened studies, 16 were selected, 14 case-control and two split-mouth studies, in which 465 immature necrotic permanent teeth, particularly incisors and premolars, were treated. Of these 465 teeth, 457 (98.2%) in both the control and experimental groups remained clinically asymptomatic for the entire study duration, whereas eight (1.8%) showed signs and symptoms of failure, including spontaneous pain, sensitivity to percussion or reinfection. Compared with control teeth, teeth treated with platelet-rich plasma or platelet-rich fibrin showed improved periapical healing (RR 1.09, 95% CI 1.00–1.20, P = 0.05), apical closure (RR 1.04, 95% CI 0.86–1.25, P = 0.69), root lengthening (RR 1.01, 95% CI 0.74–1.39, P = 0.93), and thickening of the dentin walls (RR 1.32, 95% CI 0.96–1.81, P = 0.08), although these differences were not statistically significant.
Conclusions
Platelet concentrates can act as successful scaffolds for regenerative endodontic treatment, although they did not differ significantly from conventional blood clot scaffolds.
Effect of grit blasting on fatigue life of aged 18Ni(300) maraging steel
Authors: PALAU JOSE CARLOS FORTES , Travessa Dilermando Nagle
Published: August 2022

The fatigue life of aged 18Ni300 maraging steel was investigated in two different surface conditions: polished and grit-blasted. Axial fatigue tests results, plotted in the form of S-N curves were used to correlate the fatigue performance and the surface characteristics, carefully characterized using a combination of experimental techniques, including X-ray diffraction (XRD), contact profilometry, microhardness testing, scanning electron microscopy (SEM), and stereo optical microscopy (S-OM). The results show that turn-machining of round fatigue samples forms a thin recrystallized layer over the steel surface, which remains after polishing. Roughness increases significantly after grit-blasting, but strain hardening and compressive residual stresses developed after blasting outweigh the deleterious increase of roughness and the fatigue life increases in comparison to the polished condition. Both crack initiation and propagation are retarded under the effects of blasting.
Blood Urea Nitrogen to Serum Albumin Ratio: A Good Predictor of in-Hospital and 90-Day All-Cause Mortality in AECOPD Patients
Authors: Zeng Zixiong , Ke Xiaocui , Gong Shan , Huang Xin , Liu Qin , Huang Xiaoying , Cheng Juan , Li Yuqun , Wei Liping
Published: August 2022

Background: Compared with survivors,previous studies of AECOPD have found that those died in hospital had higher blood urea nitrogen levels and poorer nutritional status.Nevertheless,the association between blood urea nitrogen to serum albumin ratio (BUN/ALB ratio) and in-hospital and short-term prognosis in AECOPD patients remains unclear.The aim of this study was to explore the usefulness of BUN/ALB ratio in AECOPD as an objective predictor for in-hospital and 90-day all-cause mortality.Methods: BUN/ALB ratio levels were measured in AECOPD patients on admission.By drawing the ROC curve of the patients,we obtained the cut-point of the BUN/ALB ratio level for in-hospital death.Multivariate logistic regression was used for analyses of the factors of in-hospital mortality and multivariate Cox regression was used to analyse the factors of 90-day all-cause mortality.Results: A total of 362 patients were recruited and 319 patients were finally analyzed,23 patients died during hospitalization and the fatality rate was 7.2%. Furthermore,14 patients died during 90-day follow-up.Compared with those in-hospital survivors,patients who died in hospital were older(80.78±6.58vs.75.09±9.73 years old, P =0.001),had a higher percentage of congestive heart failure(69.6% vs.27.4%, P<0.001),had higher BUN/ALB ratio levels(0.329(0.250,0.399)vs.0.145(0.111,0.210), P<0.001),had higher neutrophil counts(10.27(7.21，14.04)vs.6.58(4.58，9.04), P<0.001),higher blood urea nitrogen levels(10.86(7.10,12.25) vs.5.35(4.14,7.40), P<0.001),a lower albumin level(32.58±3.72vs.36.26±4.53, P<0.001) and had a lower lymphocyte count(0.85(0.58,1.21) vs.1.22(0.86,1.72), P=0.001).The ROC curve showed that the area under the curve (AUC) of BUN/ALB ratio for in-hospital death was 0.87, (95%CI: 0.81-0.93, P< 0.001), the best cut-point value to discriminate survivors from nonsurvivors in hospital was 0.249, the sensitivity was 78.3%, the specificity was 86.5%, and the youden’s index was 0.648.Having an BUN/ALB ratio ≥0.249 was an independent risk factor for both in-hospital and 90-day all-cause mortality after adjustment for relative risk(RR)(RR=15.08,95% CI:3.80-59.78, P< 0.001 for the multivariate logistic regression analysis) and hazard ratio (HR)(HR=5.34,95% CI:1.62-17.57, P=0.006 for the multivariate cox regression analysis).Conclusion: An elevated BUN/ALB ratio level was a strong and independent predictor of in-hospital and 90-day all-cause mortality in AECOPD patients.
Addressing Scalability Issues in Blockchain: A Use case from Healthcare
Authors: Sadath Lipsa , Mehrotra Deepti , Kumar Anand
Published: August 2022

The opportunities with blockchain technology has grown immensely especially with its unique features such as immutability, transparency, decentralization etc. It is also important that the basic features such as privacy, security and scalability co-exists. Our novel study proposes a framework named ERSB (Enhanced Reliability of a Scalable Blockchain) implemented with Hyperledger fabric as a solution to address scalability issues. Multiple records are generated and processed during a patient’s hospital visits/stays, laboratory tests and insurance claims. When there are networks of hospitals under one umbrella (a group of hospitals), it is critical to address maintenance of this complex system in context of the afore-mentioned unique features. Our proposed framework uses a hierarchical model at hospital networks, laboratory and insurance company that has multiple levels. Stages are evaluated with nodes added along with smart contracts. Smart contracts are also amended with more changes to observe performance, reliability and latency of the model at the first level of hierarchy.
Material Flow Optimisation of Multistage, Multiproduct Parallel Lines
Authors: BHOSALE KAILASH
Published: August 2022

In the production planning phase, long-term decision problems are addressed. In this phase, the demand of the products is fulfilled by considering the production capacity, available time and available manpower. The demand of the products is determined by Monte-Carlo simulation method. The objective function is considered to minimise material flow time. A case study based on soap finishing line which is related to multistage, multiproduct parallel line is selected. The mathematical model is formulated as mixed integer nonlinear programming. The CPLEX optimisation solver is used to find the optimum solution.
Predictive value of ferroptosis-related biomarkers for diabetic kidney disease: A prospective observational study
Authors: Wu You , Sun Yunwei , Wu Yiwei , Zhang Kecheng , Chen Yan
Published: August 2022

Objective
To explore the predictive value of ferroptosis-related (FR) biomarkers for diabetic kidney disease (DKD) in patients with type 2 diabetes mellitus (T2DM).
Methods
This prospective observational study enrolled patients with T2DM at the Second Hospital of Jilin University between December 2021 and March 2022. DKD was measured by the urinary albumin to creatinine ratio (UACR). Receiver operator characteristic curve (ROC) analysis were performed to assess the predictive value of ferroptosis-related biomarkers for DKD.
Results
Finally, 118 patients (53.0 ± 12.2 years, 76 males) were enrolled, 52 of them without DKD (had normal proteinuria), while 66 with DKD (41 had microproteinuria, and 25 had massive proteinuria). FR biomarkers, including acyl-coa synthase long chain family member 4 (ACSL4), malondialdehyde (MDA), and reactive oxygen species (ROS) were significantly higher in the massive proteinuria group than in the other groups, while glutathione peroxidase 4 (GPX4) was significantly lower (all P < 0.05). The area under the ROC of the combination of GPX4, ACSL4, MDA, and ROS for predicting DKD was 0.804 (P < 0.001). Additionally, multivariate logistic regression analysis showed that the course of disease and ferritin levels were independent risk factors for massive proteinuria, while high serum iron, transferrin, and GPX4 levels were independent protective factors for massive proteinuria in patients with T2DM (all P < 0.05).
Conclusion
The GPX4, ACSL4, MDA, and ROS combination might have a good predictive value for DKD. Additionally, the course of disease, ferritin levels, serum iron, transferrin, GPX4 were independently associated with massive proteinuria.
A promising antibacterial wound dressing made of electrospun Poly (Glycerol Sebacate) / Gelatin with local delivery of Ascorbic Acid and Pantothenic Acid
Authors: Kermani Pariya Khaloo , Kharazi Anousheh Zargar
Published: August 2022

Wounds can be caused by cuts, burns, surgeries, illnesses or accidents. The wound healing process can be disrupted by improper treatment conditions. The use of wound dressings has been the best treatment for chronic wounds. In this study, first, Poly (Glycerol Sebacate) was synthesized; then Poly (Glycerol Sebacate)-gelatin copolymer wound dressing containing vitamin B5 was made by electrospinning method. The membrane was crosslinked in the EDC/NHS solution and then loaded with vitamin C. The results indicated passage of water vapor, hydrophilicity and water absorption in samples with vitamins were ideal for wound healing process and absorption exude at wound site. On the other site, the degradation process showed the wound dressing stable during 14 days. As the following, the vitamin C and vitamin B5 release demonstrated burst release during 1 and 6 hours, respectively. Antibacterial results showed the presence of vitamin B5 in PGS/gelatin wound dressing can prevent the gram-negative and gram-positive bacteria growth. According cell viability assay, Vitamin C enhanced cell adhesion and cell proliferation. Finally, the PGS/gelatin with vitamin C/ vitamin B5 wound dressing with ideal biological properties recommend as a suitable wound healing product.
Helicobacter pylori infection upregulates miR-135b-5p to stimulate gastric cancer cell proliferation and inhibit cell apoptosis through activated IL-6/STAT3 signaling
Authors: Fang Rui , Shao Linlin , Zhou Anni , Li Xiao , Zhao Guiping , Qiao Chen , Zhang Nan , Zhang Shutian , Li Peng
Published: August 2022

Background
Helicobacter pylori (H. pylori) infection is a strong pathogenic factor of gastric cancer (GC). The dysregulation of microRNAs (miRNAs) has been correlated with gastric tumorigenesis, but their role in H. pylori-induced GC remains inadequately evaluated.
Methods
In situ hybridization was performed for evaluation of miR-135b-5p expression in GC patients. MTS assay, EdU cell imaging assay, live cell imaging and flow cytometric analysis were achieved for functional assessment of miR-135b-5p. Quantitative real-time PCR, western blot, chromatin immunoprecipitation, luciferase reporter assay and immunohistochemistry were used for exploration of regulatory mechanism and identification of target gene.
Results
Our study indicated that miR-135b-5p expression was increased in GC patients, and overexpression of miR-135b-5p stimulated GC cells proliferation and inhibits cell apoptosis. Mechanistically, H. pylori infection increased miR-135b-5p expression through the activation of the IL-6/STAT3 signaling, and STAT3 regulates miR-135b-5p via binding to its promoter directly. Furthermore, miR-135b-5p promoted GC progression by interfering TXNIP 3’ untranslated region and suppressing its protein expression, thereby affecting AKT phosphorylation. Expression of TXNIP was decreased in GC patients, and low expression levels of TXNIP in human GC patients is correlated with poor survival.
Conclusions
Our findings revealed a mechanism that H. pylori infection stimulates upregulation of miR-135b-5p via IL-6/STAT3 signaling and promotes gastric carcinogenesis, which brings up a promising diagnostic biomarker and provides an insight into therapeutic strategies for H. pylori-associated GC.
Liquefaction resistance of partially saturated sands
Authors: Zeybek Abdülhakim
Published: August 2022

Partially saturated sands with occluded gas bubbles may occur naturally in the field or can be created artificially as a way of mitigating liquefaction effects. The gas bubbles in pore spaces significantly alter the bulk modulus of pore fluid and consequently affect the excess pore pressure generation and liquefaction behavior of sands. This study aims to investigate the main parameters influencing the liquefaction resistance of partially saturated sands containing occluded gas bubbles. It also adopts a simplified approach and proposes empirical relationships linking liquefaction resistance ratio to bulk modulus, maximum volumetric strain, and excess pore pressure ratio. Considering these objectives, a total of 60 stress-controlled dynamic triaxial tests were conducted. Nearly/fully saturated and partially saturated sand specimens, prepared using sodium percarbonate, were subjected to undrained cyclic loading with a loading frequency of 0.1 Hz. The loosely or densely packed sand specimens at different degrees of saturation (79-100%) were examined under different initial effective confining stresses (25-100 kPa) and back pressures (100-400 kPa). The analysis of the test results indicated that the liquefaction resistance of partially saturated sands constantly increases as the degree of saturation decreases, and this effect is more prominent under higher initial effective confining stresses and lower back pressures. The adopted method satisfactorily captures this trend, showing reasonable matches between the empirical predictions and experimentally observed results from this study and previous research.
Magnitude of Malaria and Associated Factors Among Febrile Patients Visiting Public Health Facilities in Olanchity Town, East Shewa, Central Ethiopia, 2022. Crosssectional Study Design.
Authors: Gudeta Yosef , Daniel Radiet , Aman Duret
Published: August 2022

Background: Mortality and Morbidity caused by malaria is a major public health problem in developing countries like Ethiopia. Despite efforts to reduce its impact on community, the disease is still a projecting health problem in Ethiopia. In the study area, there is no study done that indicated extent of malaria and predisposing factors related as far as our knowledge concerned. This study, therefore, was undertaken to assess the magnitude of malaria and associated factors among febrile patient visiting public health facilities in Olanchit Town.Objectives: to assess the magnitude of malaria and associated factors among febrile patients visiting public health facilities in Olanchit Town, East Shewa, Central Ethiopia.Methods: Institution based cross sectional study was conducted from April 1st - June 30th, 2022. Every other febrile patient from all patients visiting the health facilities during the data collection period were interviewed using structured interviewer administered questionnaire. The collected data was coded, edited and entered in to Epi-Info version 7.1 and analyzed SPSS version 24. Descriptive statistics was performed to describe the magnitudes of malaria. Multiple logistic regression analysis was conducted to identify associated factors at 95% confidence interval and P -value <0.05 was used as cut-off points to declare significance in the final model.Result: in the study 306 respondents were involved making response rate 100%. Among febrile cases visited public health 85 (27.8%), (95% CI;17.0, 26.1) were positive for malaria cases and P. Vivax 43 (14.1%) were dominant species followed by mixed 26 (8.5%) and more cases 47 (15.4%) were observed in male. Malaria infection were associated with Sex who are male in gender (AOR = 5.7; 95% CI. 2. 74 – 16.1; P= 0.021), Age (AOR =7.7, 95% CI; 2.191 – 27. 321, P= 0.007), family members ever contracted malaria in their life (AOR = 3.7; 95% CI 1.469, 7.108; P = value 0.004).Conclusion and Recommendation: malaria cases found in this report was high when compared with strategies being followed now by MOH. To lower the prevalence of malaria infection there should be strong community mobilizer and active case search which might contribute to elimination goal that targeted clearing new and existing cases.
Correlates of substance use in a large naturalistic cohort of young people with early and emerging psychosis
Authors: El-Hage D. , Gao C. X. , Bedi G. , Guerin A. , Francey S. , Stavely H. , Rickwood D. , Telford N. , McGorry P. , Thompson A. , Brown Ellie
Published: August 2022

Background: Substance use remains a barrier to recovery for young people accessing early intervention services for psychosis. While correlates of use have been explored in populations experiencing a First Episode of Psychosis (FEP), sample sizes have been small and less research assesses cohorts at Ultra-High Risk of psychosis (UHR). Methods: This study uses data from a naturalistic cohort including UHR and FEP participants (N= 1252) to elucidate clinical correlates of use in the past three months of any illicit substance, amphetamine-type stimulants (ATS), cannabis, and tobacco. Moreover network analysis of these substances and additionally alcohol, cocaine, hallucinogens, sedatives, inhalants, and opioids was completed. Results: Young people with FEP used substances at significantly higher rates than those at UHR. High confluence of use was seen between substances. In the FEP group, participants who had used any illicit substance, ATS, and/or tobacco had increased positive symptoms and decreased negative symptoms. Young people with FEP who used cannabis had increased positive symptoms. In the UHR group participants who had used any illicit substance, ATS, and/or cannabis in the past 3 months showed decreased negative symptoms compared to those who had not. Conclusion: A distinct clinical picture of more florid positive symptoms and alleviated negative symptoms seen in those who use substances in the FEP group appears muted in the UHR cohort. Treating young people at UHR in early intervention services represents an opportunity to address substance use early in order to improve outcomes, particularly in those who go on to experience FEP.
A Prognostic Risk Score Based on Genes related with m 7 G regulators for the Prognosis and Immunotherapy Response of Lung Adenocarcinoma
Authors: Xia Ning , Nie Xiuhong , Wang Hao , Zhang Lin , Chen Yu
Published: August 2022

Background: Lung adenocarcinoma (LUAD) is the most common subtype of lung cancer and is significantly correlated with poor prognosis. N7-methylguanosine (m7G) modification plays an important role in occurrence, progression, and prognosis of cancer. The present study aimed to construct a prognostic risk model based on m7G-related genes for LUAD. Methods: In this study, we used data from TCGA-LUAD for the training cohort and GSE72049 and GSE31210 for the validation cohorts. Univariate Cox regression, Lasso regression analyses, and multivariate Cox regression analyses were conducted to construct an m7G-related genes risk model. We then applied multivariate Cox regression, Kaplan-Meier analysis, and Receiver operating characteristic (ROC) curves to evaluate the risk model. Finally, we analyzed the immune microenvironment and immunotherapy response with the risk score model in LUAD.Results: A novel prognostic risk model based on the four m7G-related genes (ANLN, KRT6A, NTSR1 and RHOV) was constructed. The multivariate Cox analysis showed that the prognostic risk model was an independent risk factor (HR 1.224, 95% CI 1.162-1.290, P＜0.001). Patients in the high-risk group showed an increased risk of mortality in training cohort(HR 2.04, 95%CI 1.49-2.79, P＜0.001) and validation cohorts(HR 2.46, 95%CI 1.7-3.56; HR 3.85, 95%CI 1.98-7.49). The 1, 3, and 5-year AUC value in TCGA was 0.755, 0.71, and 0.631, respectively; The 1, 3, and 5-year AUC value in GSE72049 was 0.709, 0.672, and 0.762, respectively; The 1, 3, and 5-year AUC value in GSE31210 was 0.715, 0.649, and 0.709, respectively. The high-risk patients were more likely to respond to immunotherapy than the low-risk group(P＜0.001).Conclusion: A novel prognostic risk model based on m7G-related genes was established in this study, which may predict clinical prognosis and immunotherapeutic responses in LUAD patients.
Analysis of macro and micronutrient contents and spatial distribution for assessment at regional-scale: Case study Vushtrria region (Kosovo)
Authors: Shehu Ilir
Published: August 2022

Soil fertility determines crop growth productivity and consequently affects quality and sustainability. Thirty composite samples were taken, most in intensive cultivation and some in uncultivated soil. For soil analysis, classic and instrumental methods were used. Micronutrients in soil were measured by the ICP-OES method. Assessing contents, relationships between macro and micronutrients, and spatial distribution, were used methods descriptive statistics, Pearson correlation, Arcgis pro map, clusters, and PCA analyses. The physicochemical properties and potassium levels reflect the balanced distribution. Nitrogen (N) and Phosphorus (P) were at depleted levels. The kriging interpolation patterns showed uniform distribution of macronutrients, small changes were presented in uncultivated soil. Iron (Fe) and copper (Cu) showed acceptable balances, Nickel (Ni), Molybdenum (Mo), and Zinc (Zn) showed increased values compared to the New Dutch list and SEPA, while Boron (B) and selenium (Se) were at low content. PCA analysis and Dendrograms reflected the grouping of variables in one component resulting in the same source. Correlation analysis displays significant relationships between the parameters which were related to the inorganic component of the soil. Is recommended to add fertilizers, and micronutrients for balancing based on good practices and continuous monitoring.
Predictive value of frailty assessment tools in patients undergoing surgery for gastrointestinal cancer
Authors: Zhang Huipin , Zhang Hailin , Zhou Xiaomin , Chen Guanjie , Zhou Qifan , Tang Jie , Zhu Ziye , Wang Wei
Published: August 2022

Purpose
We used three commonly used frailty assessment tools to investigate the current status of preoperative frailty and to analyse their predictive value for prognosis in patients undergoing surgery for gastrointestinal cancer.
Methods
This single-centre, observational, prospective cohort study was conducted at the Affiliated Lianyungang Hospital of Xuzhou Medical University from August 2021 to July 2022. A total of 229 patients aged ≥ 18 years who underwent surgery for gastrointestinal cancer were included in this study. We collected the patients’ baseline data and used the Comprehensive Geriatric Assessment (CGA), Fried Phenotype (FP), and the FRAIL scale to assess frailty. The outcome measures were the complications experienced by patients and increased hospital costs.
Results
The prevalence of frailty was assessed using the CGA, FP, and FRAIL scale which returned the results 65.9%, 47.6%, and 34.9%, respectively. Multivariate logistic analysis confirmed that CGA was independently associated with increased hospital costs (OR = 2.514, 95% CI [1.202–5.258]; p = 0.014), and none of the frailty assessment tools were associated with total complications.
Conclusions
CGA was an independent predictor of increased hospital costs in patients undergoing surgery for gastrointestinal cancer.
Prediction for surface roughness of the large-pitch internal thread based on homologous isomerism data
Authors: Li Zhe , Qin Xiaobo , Fu Xiangfu , Jiang Bin , Cong Weiqi , Zhang Quanjian
Published: August 2022

For the problem of difficulty in measuring the surface roughness of large-pitch internal threads, predictions are used instead of measurements, whereas the common predictions are not highly accurate and narrow in scope of use. In this paper, the homologous isomerism data of vibration signal were utilized to establish a predictive model, which predicted the surface roughness of large-pitch internal threads. The corresponding homologous isomerism data were acquired by turning the large-pitch internal thread, and the data were processed using Relief-F algorithm to obtain the weights, which are the effects of different features on surface roughness. Additionally, influenced by the structural characteristics of the workpiece with a large pitch and a small number of teeth, support vector machine (SVM) and RBF neural network, which are suitable for researches with small sample sizes, from the machine learning algorithm were used to establish the predictive model with the homologous isomerism data of vibration signal as the input parameters. Eventually, the SVM model with higher accuracy of prediction and better ability of generalization was more appropriate for the research of this paper through comparison and analysis. The SVM model was verified to have absolute errors within 0.05μm and relative errors within 4% for turning both left and right threaded surface, demonstrating that the predictive model could take the place of measuring the surface roughness in the mass production of large-pitch internal threads. The method proposed in this paper can also be extended to other parts for the prediction of surface roughness, especially those whose surface roughness are difficult to measure due to structural characteristics.
Drivers of sex differences in the South African adult tuberculosis incidence and mortality trends, 1990-2019
Authors: Kubjane Mmamapudi , Cornell Morna , Osman Muhammad , Boulle Andrew , Johnson Leigh
Published: August 2022

Males have higher tuberculosis incidence and mortality rates than females. This study aimed to assess how sex differences in tuberculosis incidence and mortality could be explained by sex differences in HIV, antiretroviral treatment (ART) uptake, smoking, alcohol abuse, undernutrition, diabetes, social contact rates, health-seeking patterns, and treatment discontinuation. We developed an age-sex-stratified dynamic tuberculosis transmission model and calibrated it to South African data. We estimated male-to-female (M:F) tuberculosis incidence and mortality ratios, the effect of the abovementioned factors on the M:F ratios and population attributable fractions (PAFs) for the tuberculosis risk factors. Between 1990 and 2019, M:F ratios for tuberculosis incidence and mortality remained above 1.0, reaching 1.70 and 1.65, respectively in 2019. In 2019, HIV contributed to more significant increases in tuberculosis incidence among females than males (54.5% vs 45.6%); however, females experienced more reductions due to ART than males (38.3% vs 17.5%). PAFs for tuberculosis incidence due to alcohol abuse, smoking, and undernutrition, in males, were 51.4%, 29.5%, and 16.1%, respectively, higher than in females (30.1%, 15.4%, and 10.7%, respectively); the PAF due to diabetes was higher in females than males (22.9% vs 17.5%). Lower health-seeking rates in males accounted for a 7% higher mortality rate in men. The higher burden of tuberculosis in men highlights the need to improve men’s access to routine screening and ensure earlier diagnosis. Sustained efforts in providing ART is critical in reducing HIV-associated tuberculosis. Additional interventions to reduce alcohol abuse and tobacco smoking are also needed.
Micro-Kernels for Portable and Efficient Matrix Multiplication in Deep Learning
Authors: Alaejos Guillermo , Castelló Adrián , Martínez Héctor , Alonso-Jordá Pedro , Igual Francisco D. , Quintana-Ortí Enrique S.
Published: August 2022

We demonstrate that it is possible to rapidly assemble an amplevariety of high performance micro-kernels for the general matrix multiplica-tion (gemm) using vector intrinsics to exploit the SIMD (single instruction,multiple data) units in current general-purpose processors. For the particulartype of applications arising in deep learning, our experiments expose that theintrinsics-based micro-kernels can deliver efficiency on par with or even higherthan the conventional, carefully tuned implementations of gemm in currentlinear algebra libraries for ARM-based processors equipped with 128-bit SIMDunits and, to a lower extent, in processors with 512-bit SIMD units.
Water-Soluble Supramolecular Polymers Driven by Naphthalene- Naphthalene Interaction
Authors: Xue Weijian , Li Huiqian , Zhang Ying , Liu Yang , Zhao Bing , Guo Xiangfeng
Published: August 2022

Supramolecular polymers play a pivotal role in scientific and technological fields because of their inherent recyclability and their self-healing and stimuli-responsive properties. A water-soluble C-shaped receptors based on glycoluril and naphthalene building blocks is reported. The complexation formed in water was confirmed by 1H NMR spectroscopy and NOESY technique. 1H NMR spectroscopy, fluorescence spectroscopy and DLS measurements provide strong evidence that compound 2 undergoes self-recognition that naphthalene moiety can bind into the bisnaphthalene cleft and head-to-tail host–guest complexation to form a new supramolecular polymers in water. SEM and AFM visualized that the complexation formed the cyclic structure. This kind of highly designable monomer structure has great possibility to construct novel supramolecular polymer materials. Graphic abstract
Effect of B12 and folate deficiency in hypomethylation of ACE-2 gene and severity of disease among the ARDS patients
Authors: Najafipour Reza , Mohammadi Davood , Momeni Abdolmabood Mabood , Moghbelinejad Sahar
Published: August 2022

Angiotensin I converting enzyme 2 (ACE-2) is the most important receptor in the entry of corona virus in host cells. The present study aimed to investigate the different mechanisms involved in the expression regulation of the this gene among the covid-9 patients. A total of 140 patients with covid-19 (n = 70 mild covid-19, n = 70 ARDS) and 120 controls were recruited. The expression of ACE-2 and miRNAs was evaluated by quantitative real time PCR (QRT-PCR), and methylation of CpG dinucleotides in the ACE2 promoter was quantified using bisulfite pyro-sequencing. Finally, different polymorphisms of the ACE-2 gene were studied by sanger sequencing. Our results showed a significant high expression of the ACE-2 gene in the blood samples of acute respiratory distress syndrome (ARDS) patients (3.8 ± 0.77) in comparison to controls (0.88 ± 0.12) (P < 0.03). The methylation rate of the ACE-2 gene in ARDS patients was 14.07 ± 6.1 in contrast to controls (72.3 ± 5.1) (P < 0.0001). Among the four studied miRNAs, only miR200c-3p showed significant downregulation in ARDS patients (0.14 ± 0.1) in comparison to controls (0.32 ± 0.17)(P < 0.001). We did not see a substantial difference in the frequency of rs182366225 C > T and rs2097723 T > C polymorphisms between patients and controls (P > 0.05). There was a significant correlation between B12 (R=-0.32, P < 0.001), folate (R=-0.37, P < 0.001) deficiency and hypo-methylation of the ACE-2 gene. These results for the first time indicated that among the different mechanisms of ACE-2 expression regulation, its promoter methylation is very crucial and can be affected by factors involved in one-carbon metabolisms such as B9 and B12 vitamins deficiency.
mmu_circ_0009303 improves nonalcoholic fatty liver disease by regulating lipid metabolism and oxidative stress in vivo and in vitro
Authors: Zhou Ju , Li Wu , Chi Xiaowei , Li Dingchun , Yang Chunxia , Duan Zhiwen
Published: August 2022

Objective
Recent studies indicated that cricRNA may play an important role in regulating inflammation and oxidative stress in the pathogenesis of NAFLD. However, its mechanism is still unclear. The purpose of this study is to further explore its role in NAFLD based on the previous discovery of the expression of mmu_circ_0009303 was significantly increased in the mouse model of NAFLD.
Methods
To achieve this goal, we use bioinformatics technology to analyze its potential targets, and then established a model of NAFLD in vitro and use oil red staining, cell transfection, dual-luciferase reporter assay and other methods to test this hypothesis.
Results
The results shown that the expression of mmu_circ_0009303, a circular RNA, was significantly increased in NAFLD models in vivo and in vitro. And its abnormal expression is closely related to the level of oxidative stress and inflammation. Moreover, we found that miRNA-182-5p and Foxo3 were act as a target of mmu_circ_0009303 and miRNA-182-5p, respectively, by bioinformatics analysis. In vitro NAFLD model showed that mmu_circ_0009303 can promote fat deposition in NCTC1469 cells induced by free fatty acid via regulating miRNA-182-5p/Foxo3. Meanwhile, we also found that the gene expression of miRNA-182-5p and Foxo3 was related to mmu_circ_0009303 in the liver of NAFLD mice induced by high-fat diet. In addition, mmu_circ_0009303 was also been proved to be involved in regulating the expression of lipid metabolism related regulatory proteins such as CPT1A, SLC27A4, ACBD3, SREBP1, FAS, PPARα and PPARγ.
Conclusion
mmu_circ_0009303 promotes oxidative stress, inflammation and accumulation of excessive fat in NCTC1469 cells induced by free fatty acid via regulating miRNA-182-5p/Foxo3 and lipid metabolism related regulatory proteins, which may be provide a potential target for the treatment of NAFLD.
Chemoradiation versus surgery for superficial esophageal squamous cell carcinoma after noncurative endoscopic submucosal dissection: comparison of long-term oncologic outcomes
Authors: Suzuki Gen , Yamazaki Hideya , Aibe Norihiro , Masui Koji , Kimoto Takuya , Nagasawa Shinsuke , Watanabe Sho , Seri Sho , Asato Akito , Shiozaki Atsuhi , Fujiwara Hitoshi , Konishi Hirotaka , Dohi Osamu , Ishikawa Takeshi , Yamada kei
Published: August 2022

Background: Esophagectomy is the standard adjuvant treatment for superficial esophageal squamous cell carcinoma (SESCC) following noncurative endoscopic submucosal dissection (ESD). However, recent reports have also shown that ESD with adjuvant chemoradiotherapy (CRT) has promising results. This retrospective study aimed to elucidate the efficacy of CRT compared to surgery in patients with SESCC after noncurative ESD.Methods: This study retrospectively compared the long-term outcomes of patients who received adjuvant treatment with surgery or CRT after noncurative ESD for SESCC.Results: Data were collected from 60 patients who developed SESCC after noncurative ESD, 34 of whom received adjuvant chemoradiotherapy (CRT) and 26 underwent esophagectomy. The median follow-up periods were 46 and 56 months in the CRT and esophagectomy groups, respectively. The median patient age was significantly higher in the CRT group than in the esophagectomy group (69 vs. 65 years, p = 0.0054). CRT was completed in all patients, and the incidence of grade ≥3 nonhematologic adverse events was 6%. The overall and disease-free survival did not significantly differ between the two groups.Conclusions: CRT following ESD seems a promising nonsurgical strategy for optimizing the selection of therapies for high-risk SESCC.
Evaluation of resistance of human head lice to pyrethroid insecticides: a meta-analysis study
Authors: Abbasi Ebrahim , Daliri Salman , Yazdani Zahra , Mohseni Shokrollah , Mohammadyan Ghulamraza , Hosseini Seyedeh Niloofar Seyed , Haghighi Reza Nasiri
Published: August 2022

Introduction:
Pediculosis is one of the most common annoying infections caused by insects in humans. Pyrethroids are one of the main insecticides used to treat this infection. But recently, due to the resistance of lice to this group of insecticides, its therapeutic effects have been affected. Based on this, the present study was conducted to investigating the prevalence of resistance to treatment against these insecticides in the world in the form of a meta-analysis.
Methods
This study was conducted as a meta-analysis on the prevalence of treatment resistance in human head lice against pyrethroid insecticides in the world. Based on this, all articles published without a time limit until the end of June 2022 in PubMed/MEDLINE, Web of Science (ISI), Scopus, and Google Scholar databases were extracted and using random effects model statistical methods in the meta-analysis, Cochrane, Index I2 and funnel plot were analyzed by STATA software.
Results
Twenty studies were included in the meta-analysis process. According to this the prevalence of resistance to pyrethroid insecticides in human head lice was estimated at 59% (CI95%: 50–68%). Among pyrethroid insecticides, the highest prevalence of resistance to treatment against permethrin insecticide was 65%. Regarding the prevalence of resistance by year, the prevalence before 2004 was estimated at 33%, but after 2015, this rate reached 82%. Also, the prevalence of resistance to treatment was estimated at 68% using genetic diagnosis methods and 43% using clinical diagnosis methods.
Conclusion
More than half of human head lice are resistant to pyrethroid insecticides. Based on this, it is recommended that before using this treatment method to treat human head lice infestation, the prevalence of resistance to treatment in that area should be investigated and if the prevalence of resistance is high, alternative or combined treatment methods should be used.
Targeting interferon pathway in TBLR1-RARa-driven promyelocytic leukemia in the context of ATRA and ATO unresponsiveness
Authors: Yang Xue , Xing Haiyan , Qiu Shaowei , Tang Kejing , Tian Zheng , Rao Qing , Wang Min , Wang Jianxiang
Published: August 2022

Background
TBLR1-RARα (TR) is a novel oncogene to induce acute promyelocytic leukemia (APL) identified in our previous studies, which elicited differed response and worse prognosis in contrast to the canonical PML-RARα (PR) fusion gene. Despite the textbook rationale of all-trans retinoid acid (ATRA) and arsenic trioxide (ATO) has turned most PR-driven APL from highly fatal to highly curable, TR-driven APL did not yield long-term remission, highlighting the necessity to decipher drug unresponsiveness and explore novel therapies.
Methods
In this study, doxycycline-inducible cell models were established to initiate the expression of TR and PR in U937 cells, respectively. Then RNA-seq was performed to identify differential genes and pathways directly induced by TR and PR oncogene. Based on transcriptomic analyses, different drugs were administered to compare therapy responses and biological phenotypes between TR and PR-induced leukemia through in vitro studies. The efficacy of IFNs and its upstream regulator STING agonist were further validated in TR murine models with survival analysis.
Results
Transcriptome sequencing analyses showed interferon (IFN) pathway were significantly suppressed in TR- rather than PR-induced APL. IFNs as well as the traditional regimen of ATRA and ATO elicit differed responses in biological phenotypes between TR- and PR-induced APL. Specifically, in TR-induced APL, firstly, ATO failed to elicit oncoprotein degradation, apoptosis and loss of self-renewal. Secondly, increasing doses of ATRA further promoted oncoprotein degradation with impaired colony formation capacity, and ultimately conferred survival benefits. Thirdly, type I IFNs is promising, which induced apoptosis, cooperated with ATRA to boost differentiation, and exhibited potential to reduce self-renewal. Finally, type I IFNs combining with ATRA and STING agonist significantly endowed TR mice with extended survival.
Conclusions
For TR-driven APL, the canonical regimen of ATO and lower doses of ATRA are unresponsive and inadequate to elicit oncoprotein degradation, apoptosis and loss of self-renewal, while type I IFNs and STING agonist are promising to endow TR mice with extended survival. Our study aims to gain further understanding of TR-driven APL and integrate insights into leukemogenesis mediated by rare RARα fusion genes, which may benefit a therapy-resistant population and enable APL to be bona fide curable leukemia.
Analysis of Radiation Characteristics of Compressed V-shape Dipole Antenna
Authors: Xiu Menglei , Li Lihua , Feng Shimin
Published: August 2022

In order to solve the problem of blind radiation spot of the traditional whip antenna mounted on the surface unmanned boats, a compressed V-shape dipole antenna is designed, which is omnidirectional and has a larger directivity especially when the hull is tilted. Calculated the radiation field strength of the compressed V-shape dipole antenna when it is tilted in various directions; The electrical characteristics of the compressed V-shape dipole antenna were obtained using FEKO electromagnetic simulation software, and the far-field experimental measurement and comparison experiment with the traditional whip antenna and the standard V-shape dipole antenna were carried out. Theoretical calculations, simulations, and experiments all show that the compressed V-shape dipole antenna has better directivity when interfered by the flowing sea surface, and the results are consistent, avoiding the problem of blind working spots, and the radiation process is stable and reliable.
Evaluation of transcutaneous near-infrared spectroscopy for early detection of cardiac arrest in an animal model
Authors: Raschdorf Katharina , Mohseni Arman , Hogle Kaavya , Cheung Amanda , Manouchehri Neda , So Kitty , Khalili Mahsa , Lingawi Saud , Grunau Brian , Kuo Calvin , Christenson Jim , Shadgan Babak
Published: August 2022

Sudden cardiac arrest (SCA) is a leading cause of mortality worldwide. Outcomes highly depend on the SCA-to-resuscitation interval, highlighting the clinical need for quick and reliable SCA detection. Near-infrared spectroscopy (NIRS), a noninvasive optical technique, may have utility for SCA detection. We investigated the ability of hindlimb transcutaneous NIRS to detect changes with pentobarbital-induced cardiac arrest in eight Yucatan miniature pigs. NIRS measurements during cardiac arrest were compared to invasively acquired carotid blood pressure and spinal cord tissue partial oxygen pressure (PO2). We observed statistically significant decreases in mean arterial pressure (MAP) 64.68 mmHg ± 13.08, p = 0.016), spinal cord PO2 (38.16 mmHg ± 20.04, p = 0.016), and NIRS-derived tissue oxygen saturation (TSI%) (14.50% ± 3.80, p = 0.0078) from baseline to 5 minutes after pentobarbital administration. Euthanasia-to-first change in hemodynamics for MAP and TSI (%) were similar [MAP (10.43 ± 4.73 sec) vs TSI (%) (12.04 ± 1.85 sec), p = 0.605]. No significant difference was detected between NIRS and blood pressure-derived pulse rates during baseline periods (p > 0.99) and following pentobarbital administration (p = 0.97). Similar to invasive indices, transcutaneous NIRS demonstrated marked changes with cardiac arrest and was able to rapidly identify hemodynamic changes. Transcutaneous NIRS monitoring may present a novel and noninvasive approach to SCA detection.