bluuebunny/crossref_metadata_2025 huggingface dataset:
Direct numerical simulations of turbulent pipe flow up to
Authors: Yao Jie , Rezaeiravesh Saleh , Schlatter Philipp , Hussain Fazle
Published: February 2023

Well-resolved direct numerical simulations (DNS) have been performed of the flow in a smooth circular pipe of radius

$R$

and axial length

$10{\rm \pi} R$

at friction Reynolds numbers up to

$Re_\tau =5200$

using the pseudo-spectral code OPENPIPEFLOW. Various turbulence statistics are documented and compared with other DNS and experimental data in pipes as well as channels. Small but distinct differences between various datasets are identified. The friction factor

$\lambda$

overshoots by

$2\,\%$

and undershoots by

$0.6\,\%$

the Prandtl friction law at low and high

$Re$

ranges, respectively. In addition,

$\lambda$

in our results is slightly higher than in Pirozzoli et al. (J. Fluid Mech., vol. 926, 2021, A28), but matches well the experiments in Furuichi et al. (Phys. Fluids, vol. 27, issue 9, 2015, 095108). The log-law indicator function, which is nearly indistinguishable between pipe and channel up to

$y^+=250$

, has not yet developed a plateau farther away from the wall in the pipes even for the

$Re_\tau =5200$

cases. The wall shear stress fluctuations and the inner peak of the axial turbulence intensity – which grow monotonically with

$Re_\tau$

– are lower in the pipe than in the channel, but the difference decreases with increasing

$Re_\tau$

. While the wall value is slightly lower in the channel than in the pipe at the same

$Re_\tau$

, the inner peak of the pressure fluctuation shows negligible differences between them. The Reynolds number scaling of all these quantities agrees with both the logarithmic and defect-power laws if the coefficients are properly chosen. The one-dimensional spectrum of the axial velocity fluctuation exhibits a

$k^{-1}$

dependence at an intermediate distance from the wall – also seen in the channel. In summary, these high-fidelity data enable us to provide better insights into the flow physics in the pipes as well as the similarity/difference among different types of wall turbulence.
Planning, discretion and the legacy of onshore wind
Authors: Mackie Colin
Published: February 2023

This paper evaluates the wide discretion afforded to planning decision-makers in England. It does so in respect of a key but often overlooked question in the transition to renewables: whether developers/owners of onshore wind projects should be required to provide a ‘bond’ to ensure decommissioning and site restoration (DSR) occurs. Bonds are financial instruments that evidence ability to fund DSR. They help avoid legacy issues (eg project abandonment) but carry a long-term cost burden for developers/owners. A study of 275 projects elicits three issues. First, a lack of government guidance on bonding, vague ‘threshold’ terms in law and policy and failure of planning decision-makers to consider how others had decided the question result in a lack of markers to inform discretion, with bonds being rare (present in only 15.6% of projects) and their stringency inconsistent. Secondly, this lack of markers legitimises risky, cost-saving practices prohibited in offshore wind, where government guidance informs bonding decisions. Thirdly, reasons for decisions are weak or absent, inhibiting achievement of the justifications for their provision in an administrative context (eg disciplining decision-making). Whilst discretion enhanced capacity to generate electricity from wind through enabling a reduction of market entry costs, assisting movement towards renewable energy targets, it resulted in abandonment risk being ignored. This mirrors strategies adopted elsewhere in England's energy sector, such as coal and oil and gas, where a ‘light touch’ approach to bonding has, traditionally, been deployed to avoid hindering project development.
Bridging the Gap with the ‘New’ Economic History of Africa
Authors: Frankema Ewout , van Waijenburg Marlous
Published: February 2023

This review article seeks to build bridges between mainstream African history and the more historically oriented branch of the ‘new’ economic history of Africa. We survey four central topics of the new economic history of Africa — growth, trade, labor, and inequality — and argue that the increased use of quantitative methods and comparative perspectives have sharpened views on long-term trajectories of economic development within Africa and placed the region more firmly into debates of global economic development. The revival of African economic history opens new opportunities for Africanist historians to enrich the interdisciplinary approaches they have taken to study questions of demography, poverty, slavery, labor, inequality, migration, state formation, and colonialism. These fruits, however, can only be reaped if the institutional boundaries between the fields of history and economic history are softened and both sides engage in greater mutual engagement. Our paper aims to move closer to a shared vision on the benefits and limitations of varying quantitative methods, and how these approaches underpin both more and less convincing narratives of long-term African development.
Cheetahs persist in the wild in the remote Awdal region of Somaliland
Authors: Marker Laurie , Connolly Erin , Saed Abdinasir Hussein , Reasoner Emma , Aden Khadar Yasin , Cristescu Bogdan
Published: February 2023

Although cheetahs Acinonyx jubatus were once widespread in the Horn of Africa, their presence in Somaliland has not been confirmed since 2010, and they have been presumed extirpated in recent years. During 2021–2022 the Cheetah Conservation Fund and the Ministry of Environment and Climate Change in Somaliland carried out two rapid surveys in the Awdal region of western Somaliland to investigate the status of the cheetah in this area. The team collected socio-ecological data from 26 villages for a total of 13 days. In both years people from most villages reported sightings of cheetahs, and the team also received multiple reports of predation on small livestock (sheep and goats) by cheetahs. We also investigated two reports of recent cheetah presence. This led to finding a set of confirmed cheetah tracks, which we followed for > 250 m, and two large feline scrapes, both approximately the size expected of a cheetah. In 2020 and 2022 we received direct evidence of cheetah presence in the form of mature cheetah carcasses. In the first instance the cheetah was reported as having been shot in defence of livestock, and in the second instance two cheetahs were apparently poison-baited. Both reports were accompanied by photographic records. This combination of social and ecological data means that we can confirm the recent presence of wild cheetahs in western Somaliland. We will now prioritize work with local communities to understand and mitigate human–cheetah conflict and continue to investigate the distribution of cheetahs throughout Somaliland.
Increased affective reactivity to daily social stressors is associated with more severe psychotic symptoms in youths with 22q11.2 deletion syndrome
Authors: Ilen Laura , Feller Clémence , Eliez Stephan , Schneider Maude
Published: February 2023

Background

Increased reactivity to minor stressors is considered a risk factor for psychosis, especially in vulnerable individuals. In the present study, we investigated affective and psychotic stress reactivity as well as its link with psychotic symptoms and psychopathology in youths with 22q11.2 deletion syndrome (22q11DS), a neurogenetic condition associated with a high risk for psychosis.

Methods

A 6-day ecological momentary assessment protocol was used to assess perceived daily-life stress as well as affective and psychotic reactivity to stress in participants with 22q11DS (n = 38, age = 18.4) and healthy controls (HC; n = 53, age = 19.1). Psychotic symptoms, general psychopathology, and coping strategies were also assessed through clinical interviews and questionnaires.

Results

Participants with 22q11DS reported higher levels of perceived social stress (b = 0.21, p = 0.036) but lower levels of activity-related stress (b = −0.31, p = 0.003) in their daily lives compared to HC. The groups did not differ in affective or psychotic reactivity to stress, but individuals with 22q11DS who reported increased affective reactivity to social stressors showed more severe positive psychotic symptoms (rs = 0.505, p = 0.008). Finally, avoidance coping strategies moderated the association between stress and negative affects.

Conclusions

Our results suggest an increased vulnerability for daily social stress in youths with 22q11DS, and link elevated social stress reactivity to heightened psychotic symptom severity. Given the high risk for psychosis in 22q11DS, interventions should focus on reducing social stress and developing adaptive coping strategies.
NGOs and the Promotion of the Sexual and Reproductive Rights of Girls and Young Women with Disabilities in Zimbabwe
Authors: Rugoho Tafadzwa , Ganle John Kuumuori , Stein Michael Ashley , Groce Nora , Wright E. Pamela , Broerse Jacqueline E. W.
Published: February 2023

This case study investigates strategies used by the NGO Leonard Cheshire Disability Zimbabwe (LCDZ) to promote the SRHRs of girls and young women with disabilities in Zimbabwe. The findings show that LCDZ employed a combination of six strategies. These are: (1) building practical knowledge on SRHRs; (2) increasing community awareness and sensitivity; (3) providing SRHRs-related education; (4) enhancing access to justice and related services for survivors of sexual violence; (5) delivering assistive devices; and (6) promoting the livelihoods and economic empowerment. LCDZ made use of multi-stakeholder partnerships to implement these strategies, leveraging complementary skills and experience in the promotion of SRHRs. In each of these strategies, girls and young women with disabilities are the target group, with other stakeholders brought together to support them.
Language and pain predict persistent depression among seriously ill home care clients
Authors: Ameen Aaisha , Williams Nicole , Guthrie Dawn M.
Published: February 2023

Objectives

This study examined potential predictors of persistent depressive symptoms in a cohort of seriously ill older adults (aged 65+ years) receiving home care services.

Methods

This was a retrospective cohort study using secondary data collected from the Resident Assessment Instrument for Home Care for all assessments completed between 2001 and 2020. The cohort included seriously ill individuals with depressive symptoms at baseline and who continued to have depressive symptoms on reassessment within 12 months (n = 8,304). Serious illness was defined as having severe health instability, a prognosis of less than 6 months, or a goal of care related to palliative care (PC) on admission to the home care program.

Results

The mean age of the sample was 80.8 years (standard deviation [SD] = 7.7), 61.1% were female, and 82.1% spoke English as their primary language. The average length of time between assessments was 4.9 months (SD = 3.3). During that time, 64% of clients had persistent symptoms of depression. A multivariate logistic regression model found that language, pain, caregiver burden, and cognitive impairment were the most significant predictors of experiencing persistent depressive symptoms.

Significance of results

Persistent depressive symptoms are highly prevalent in this population and, left untreated, could contribute to the person experiencing a “bad death.” Some of the risk factors for this outcome are amenable to change, making it important to continually assess and flag these factors so interventions can be implemented to optimize the person’s quality of life for as long as possible.
Selenium and zinc supplementation in HIV-infected patients
Authors: Pourmoradian Samira , Rezazadeh Leila , Tutunchi Helda , Ostadrahimi Alireza
Published: February 2023

Abstract: Background: The Human Immunodeficiency Virus (HIV) epidemic is still a public health concern. Micronutrient deficiencies can fasten the progression of this syndrome. Selenium and zinc are essential trace elements, which exert antioxidant and anti-inflammatory activities in HIV infection. The present overview aimed to evaluate the current knowledge from systematic reviews (SRs) of the effects of selenium and zinc supplementation in HIV patients to show the most updated and comprehensive summary of previous SRs. Methods: The current study was performed according to the guidelines of the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis) statements. To assess the quality of articles we used the Measurement Tool to Checklist Assess Systematic Reviews (AMSTAR). PubMed/Medline, Web of Science, Scopus, and EMBASE databases and Google Scholar web search engine were searched up until March 2022, using relevant keywords. Results: Among 3731 articles assessed, five and four studies met the inclusion criteria for selenium and zinc supplementation, respectively. Four studies found that selenium supplementation can be effective in delaying CD4 decline in HIV-infected patients. In four SRs, the dosage of selenium supplementation was 200 μg/day. Three studies, however, reported no significant effect of zinc supplementation on CD4 cell counts, and HIV viral load. The dosage of zinc supplementation ranged from 12 to 100 mg/day. The intervention duration ranged from 2 weeks to 18 months. Conclusion: In the present study, we identified some clinical evidence of a potential beneficial effect of selenium supplementation in HIV-infected patients.
Midlatitude Sporadic E‐Layer Horizontal Structuring Modulated by Neutral Instability and Mixing in the Lower Thermosphere
Authors: Bui Michelle X. , Hysell David L. , Larsen Miguel F.
Published: February 2023

Observations of 30‐MHz coherent backscatter from sporadic‐E ionization layers were obtained with a VHF imaging radar located in Ithaca, New York. The volume probed by the radar lies at relatively high magnetic latitudes, on the northern edge of the mid‐latitude region and underneath the ionospheric trough. Banded, quasi‐periodic (QP) echoes observed from Ithaca are similar to those found in lower midlatitude regions. The Doppler shifts observed are smaller and, so far, do not appear to reach the threshold for Farley‐Buneman instability. However, many of the echoes exhibit fine‐scale structure, with secondary bands or braids oriented obliquely to the primary bands. Secondary bands have been seen only rarely at lower middle latitudes. In previous observations, the QP scattering has been linked to unstable neutral wind shears. Neutral wind shear commonly found in the lower thermosphere could play a key role in the formation of these irregularities and explain some morphological features of the resulting plasma density irregularities and the radar echoes. We consider whether neutral instability and turbulence in the lower thermosphere is the likely cause for some of the structuring in the sporadic‐ E layers. Results of 3D numerical simulations of atmospheric dynamics in the mesosphere to lower thermosphere support the proposition. In particular, we focus on Ekman‐type instabilities that, like the more common Kelvin‐Helmholtz instabilities, are inflection point instabilities, although specifically associated with turning shears, and result in convective rolls aligned close to the mean wind direction, with smaller‐scale secondary waves aligned normal to the primary structures.
Mineral Texture Classification Using Deep Convolutional Neural Networks: An Application to Zircons From Porphyry Copper Deposits
Authors: Nathwani Chetan L. , Wilkinson Jamie J. , Brownscombe William , John Cédric M.
Published: February 2023

The texture and morphology of igneous zircon indicates magmatic conditions during zircon crystallization and can be used to constrain provenance. Zircons from porphyry copper deposits are typically prismatic, euhedral, and strongly oscillatory zoned which may differentiate them from zircons associated with unmineralized igneous systems. Here, cathodoluminescence images of zircons from the Quellaveco porphyry copper district, Southern Peru, were collected to compare zircon textures between the premineralization Yarabamba Batholith and the Quellaveco porphyry copper deposit. Quellaveco porphyry zircons are prismatic, euhedral, and strongly oscillatory zoned, whereas the batholith zircons are subhedral‐anhedral with weaker zoning. We adopt a deep convolutional neural network (CNN) approach to demonstrate that a CNN can classify Quellaveco porphyry zircons with high success. We trial several CNN architectures to classify zircon images: LeNet‐5, AlexNet and VGG, including a transfer learning approach where we used the weights of a VGG model pretrained on the ImageNet data set. The VGG model with transfer learning is the most effective approach, with accuracy and receiver operating characteristic‐area under curve (ROC‐AUC) scores of 0.86 and 0.93, indicating that a Quellaveco porphyry zircon CL image can be ranked higher than a batholith zircon with 93% probability. Visualizing model layer outputs demonstrates that the CNN models can recognize crystal edges, zoning, and mineral inclusions. We trial implementing trained CNN models as unsupervised feature extractors, which can empirically quantify crystal textures and morphology. Therefore, deep learning provides a tool for the extraction of information from large, imaged‐based petrographic data sets which can facilitate petrologic and provenance studies.
Sea Ice Production in the 2016 and 2017 Maud Rise Polynyas
Authors: Zhou Lu , Heuzé Céline , Mohrmann Martin
Published: February 2023

Sea ice production within polynyas, an outcome of the atmosphere‐ice‐ocean interaction, is a major source of dense water and hence key to the global overturning circulation, but is poorly quantified over open‐ocean polynyas. Using the two recent extensive open‐ocean polynyas within the wider Maud Rise region of the Weddell Sea in 2016 and 2017, we here explore the sea ice energy budget and estimate their sea ice production based on satellite retrievals, in‐situ hydrographic observations and the Japanese 55‐year Reanalysis. We find that the oceanic heat flux amounts to 36.1 and 30.7 W m−2 within the 2016 and 2017 polynyas, respectively. Especially the 2017 open‐ocean polynya produced nearly 200 km3 of new sea ice, which is comparable to the production in the largest Antarctic coastal polynyas. Finally, we determine that ice production is highly correlated with and sensitive to skin temperature and wind speed, which affect the turbulent fluxes. It is also strongly sensitive to uncertainties in the sea ice concentration and 1,000 hPa temperature, which all urgently need to be better monitored at high latitudes. Lastly, more process‐oriented campaigns are required to further elucidate the role of open‐ocean polynya on the local and global ocean circulations.
Downstream Controls on Coastal Plain River Avulsions: A Global Study
Authors: Colombera Luca , Mountney Nigel P.
Published: February 2023

The avulsion frequency of coastal‐plain rivers is primarily governed by the rate at which channels become superelevated over neighboring plains, which is itself controlled by multiple factors. Notably, the importance of wave and tidal processes, the rates of relative sea‐level (RSL) change, and the bathymetry of the receiving basin are thought to affect channel morphodynamics and channel‐mouth progradation, thereby controlling streambed aggradation and influencing the avulsion frequency and drainage density of coastal plains and deltas. This work tests the significance of these downstream factors on the avulsion histories of 57 Holocene lowland river systems. A quantitative analysis is performed of relationships between variables that quantify downstream controls and estimations of avulsion frequency, based on the number of avulsion events, active or abandoned channel paths, and delta lobes; measures of spatiotemporal avulsion “density” are also derived by normalizing these metrics by the size of study areas and the number of distinct drainage systems. Relationships between avulsion‐frequency metrics and descriptors of process regime indicate that wave and tidal processes may stabilize coastal channel systems, but also that their influence may be modest. No consistent relationship is seen between avulsion‐frequency proxies and the offshore bathymetric gradient, which in the studied examples does not scale with the rate of shoreline progradation. No evident trend exists between measures of avulsion frequency and estimated rates of either eustatic or RSL fluctuations. Overall, the considered variables do not leave a clear statistical signature in Holocene avulsion histories, suggesting that upstream or intrabasinal factors may represent more important controls.
Fracture Intensity Impacts on Reaction Front Propagation and Mineral Weathering in Three‐Dimensional Fractured Media
Authors: Andrews E. M. , Hyman J. D. , Sweeney M. R. , Karra S. , Moulton J. D. , Navarre‐Sitchler A.
Published: February 2023

Studying reaction front propagation in heterogeneous natural settings is challenging, but numerical simulations can provide insight into the varying spatial and temporal scales of reaction front propagation. Here, the impact of increasing fracture intensity on mineral dissolution rates, and the extent of reaction front propagation is investigated using reactive transport simulations in upscaled discrete fracture network domains with varied fracture intensity. Domain‐averaged dissolution rates vary less than 0.5 log units regardless of the fracture intensity, but the spatial distribution of reactions is controlled by the location and number of dead‐end fractures and the number of connected flowpaths through the domain. Higher fracture intensities lead to more weathering in the domain because of more available mineral for water‐rock interactions. We find that reaction fronts propagate through the primary flowpaths in the first 10,000 years of the simulation for a 10‐m length domain, then propagate into secondary flowpaths and dead‐end fractures between 10,000 and 100,000 years, and finally into the matrix over timescales of hundreds of thousands of years. The domain‐averaged reaction rates decrease through time corresponding to a transition from dissolution in advection‐dominated, fast‐flowing pathways, to dissolution in transport‐limited zones of disconnected fractures and matrix. Matrix dissolution, or dissolution under transport‐limited conditions, is the dominant process at late times in these simulations. The results of these simulations recreate the observed paradox found in nature where highly fractured hillslopes tend to be more weathered but have slower weathering rates, while hillslopes with fewer fractures, are less weathered but have higher dissolution rates.
The Role of Insurance in Climate Adaption
Authors: Duncombe Jenessa
Published: February 2023

New research tests the promise of insurance to harden the U.S. economy to tropical storms.
The neurobiology of irritable bowel syndrome
Authors: Mayer Emeran A. , Ryu Hyo Jin , Bhatt Ravi R.
Published: February 2023

Irritable bowel syndrome (IBS) is the most prevalent disorder of brain-gut interactions that affects between 5 and 10% of the general population worldwide. The current symptom criteria restrict the diagnosis to recurrent abdominal pain associated with altered bowel habits, but the majority of patients also report non-painful abdominal discomfort, associated psychiatric conditions (anxiety and depression), as well as other visceral and somatic pain-related symptoms. For decades, IBS was considered an intestinal motility disorder, and more recently a gut disorder. However, based on an extensive body of reported information about central, peripheral mechanisms and genetic factors involved in the pathophysiology of IBS symptoms, a comprehensive disease model of brain-gut-microbiome interactions has emerged, which can explain altered bowel habits, chronic abdominal pain, and psychiatric comorbidities. In this review, we will first describe novel insights into several key components of brain-gut microbiome interactions, starting with reported alterations in the gut connectome and enteric nervous system, and a list of distinct functional and structural brain signatures, and comparing them to the proposed brain alterations in anxiety disorders. We will then point out the emerging correlations between the brain networks with the genomic, gastrointestinal, immune, and gut microbiome-related parameters. We will incorporate this new information into a systems-based disease model of IBS. Finally, we will discuss the implications of such a model for the improved understanding of the disorder and the development of more effective treatment approaches in the future.
BMAL1 collaborates with CLOCK to directly promote DNA double-strand break repair and tumor chemoresistance
Authors: Zhang Canfeng , Chen Liping , Sun Lu , Jin Heping , Ren Kai , Liu Shiqi , Qian Yongyu , Li Shupeng , Li Fangping , Zhu Chengming , Zhao Yong , Liu Haiying , Liu Yan
Published: February 2023

Accumulating evidence indicates a correlation between circadian dysfunction and genomic instability. However, whether the circadian machinery directly regulates DNA damage repair, especially in double-strand breaks (DSBs), remains poorly understood. Here, we report that in response to DSBs, BMAL1 is activated by ATM-mediated phosphorylation at S183. Phosphorylated BMAL1 is then localized to DNA damage sites, where it facilitates acetylase CLOCK to load in the chromatin, regulating the acetylation of histone H4 (H4Ac) at DSB sites. In this way, the BMAL1-CLOCK-H4Ac axis promotes the DNA end-resection to generate single-stranded DNA (ssDNA) and the subsequent homologous recombination (HR). BMAL1 deficient cells display defective HR, accumulation of unrepaired DSBs and genome instability. Accordingly, depletion of BMAL1 significantly enhances the sensitivity of adrenocortical carcinoma (ACC) to DNA damage-based therapy in vitro and in vivo. These findings uncover non-canonical function of BMAL1 and CLOCK in HR-mediated DSB repair, which may have an implication in cancer therapeutics.
Beneficial effects of premeal almond load on glucose profile on oral glucose tolerance and continuous glucose monitoring: randomized crossover trials in Asian Indians with prediabetes
Authors: Gulati Seema , Misra Anoop , Tiwari Rajneesh , Sharma Meenu , Pandey Ravindra M. , Upadhyay Ashish Datt , Sati Hem Chandra
Published: February 2023

Background

Rapid conversion from prediabetes to diabetes and frequent postprandial hyperglycemia (PPHG) is seen in Asian Indians. These should be the target of dietary strategies.

Objectives

We hypothesized that dietary intervention of preloading major meals with almonds in participants with prediabetes will decrease overall glycemia and PPHG.

Design

The study included two phases: (1) an oral glucose tolerance test (OGTT)-based crossover randomized control study, the effect of a single premeal almond load (20 g) given before OGTT was evaluated (n = 60, 30 each period). (2) The continuous glucose monitoring system (CGMS)-based study for 3 days including premeal almond load before three major meals was a free-living, open-labeled, crossover randomized control trial, where control and premeal almond load diets were compared for glycaemic control (n = 60, 30 in each period). The study was registered at clinicaltrials.gov (registration no. NCT04769726).

Results

In the OGTT-based study phase, the overall AUC for blood glucose, serum insulin, C-peptide, and plasma glucagon post-75 g oral glucose load was significantly lower for treatment vs. control diet (p < 0.001). Specifically, with the former diet, PPHG was significantly lower (18.05% in AUC on OGTT, 24.8% at 1-h, 28.9% at 2-h post OGTT, and 10.07% during CGMS). The CGMS data showed that premeal almond load significantly improved 24-glucose variability; SD of mean glucose concentration and mean of daily differences. Daily glycaemic control improved significantly as per the following: mean 24-h blood glucose concentration (M), time spent above 7.8 mmol/L of blood glucose, together with the corresponding AUC values. Premeal almond load significantly decreased following: overall hyperglycemia (glucose AUC), PPHG, peak 24-h glycaemia, and minimum glucose level during night.

Conclusion

Incorporation of 20 g of almonds, 30 min before each major meal led to a significant decrease in PPHG (as revealed in OGTT-based study phase) and also improved insulin, C-peptide, glucagon levels, and improved glucose variability and glycemic parameters on CGMS in participants with prediabetes.

Clinical trial registry

The study was registered at clinicaltrials.gov (registration no. NCT04769726).
Current status of the rapid decline in renal function due to diabetes mellitus and its associated factors: analysis using the National Database of Health Checkups in Japan
Authors: Fujii Makoto , Ohno Yuko , Ikeda Asuka , Godai Kayo , Li Yaya , Nakamura Yuko , Yabe Daisuke , Tsushita Kazuyo , Kashihara Naoki , Kamide Kei , Kabayama Mai
Published: February 2023

The increasing number of patients undergoing dialysis due to diabetes mellitus (DM) is causing serious economic problems, and its reduction is an urgent policy issue in developed countries, including Japan. We aimed to assess the association between the annual rapid decline in renal function and health checkup measures, including blood pressure, to identify health guidance targets for preventing diabetic nephropathy (DN) and diabetic kidney disease (DKD) among individuals in a medical checkup system (“Tokuteikenshin” program) in 2018. This longitudinal analysis included 3,673,829 individuals who participated in the “Tokuteikenshin” program in 2018, had hemoglobin A1c (HbA1c) levels ≥5.6%, were available for follow-up, and underwent estimated glomerular filtration rate (eGFR) evaluation. We estimated the incidence of the relative annual decrease in eGFR ≥10% per 1000 person-years and odds ratios to evaluate the rapid decline in renal function and determine health guidance goals and their role in preventing DN and DKD. Overall, 20.83% of patients with DM had a rapid decline in renal function within the observation period. A rapid decline in renal function was associated with high systolic blood pressure, poor or strict DM control, increased urinary protein excretion, and decreased blood hemoglobin levels. The incidence of rapid decline in renal function is higher in DM, and appropriate systolic blood pressure and glycemic control are important to prevent the progression to DN or DKD. Our findings will be useful for researchers, clinicians, and other public health care members in establishing effective health guidance and guidelines for CKD prevention.
Pathogen evasion of social immunity
Authors: Stock Miriam , Milutinović Barbara , Hoenigsberger Michaela , Grasse Anna V. , Wiesenhofer Florian , Kampleitner Niklas , Narasimhan Madhumitha , Schmitt Thomas , Cremer Sylvia
Published: February 2023

Treating sick group members is a hallmark of collective disease defence in vertebrates and invertebrates alike. Despite substantial effects on pathogen fitness and epidemiology, it is still largely unknown how pathogens react to the selection pressure imposed by care intervention. Using social insects and pathogenic fungi, we here performed a serial passage experiment in the presence or absence of colony members, which provide social immunity by grooming off infectious spores from exposed individuals. We found specific effects on pathogen diversity, virulence and transmission. Under selection of social immunity, pathogens invested into higher spore production, but spores were less virulent. Notably, they also elicited a lower grooming response in colony members, compared with spores from the individual host selection lines. Chemical spore analysis suggested that the spores from social selection lines escaped the caregivers’ detection by containing lower levels of ergosterol, a key fungal membrane component. Experimental application of chemically pure ergosterol indeed induced sanitary grooming, supporting its role as a microbe-associated cue triggering host social immunity against fungal pathogens. By reducing this detection cue, pathogens were able to evade the otherwise very effective collective disease defences of their social hosts.
Exceptionally clean single-electron transistors from solutions of molecular graphene nanoribbons
Authors: Niu Wenhui , Sopp Simen , Lodi Alessandro , Gee Alex , Kong Fanmiao , Pei Tian , Gehring Pascal , Nägele Jonathan , Lau Chit Siong , Ma Ji , Liu Junzhi , Narita Akimitsu , Mol Jan , Burghard Marko , Müllen Klaus , Mai Yiyong , Feng Xinliang , Bogani Lapo
Published: February 2023

Only single-electron transistors with a certain level of cleanliness, where all states can be properly accessed, can be used for quantum experiments. To reveal their exceptional properties, carbon nanomaterials need to be stripped down to a single element: graphene has been exfoliated into a single sheet, and carbon nanotubes can reveal their vibrational, spin and quantum coherence properties only after being suspended across trenches1–3. Molecular graphene nanoribbons4–6 now provide carbon nanostructures with single-atom precision but suffer from poor solubility, similar to carbon nanotubes. Here we demonstrate the massive enhancement of the solubility of graphene nanoribbons by edge functionalization, to yield ultra-clean transport devices with sharp single-electron features. Strong electron–vibron coupling leads to a prominent Franck–Condon blockade, and the atomic definition of the edges allows identifying the associated transverse bending mode. These results demonstrate how molecular graphene can yield exceptionally clean electronic devices directly from solution. The sharpness of the electronic features opens a path to the exploitation of spin and vibrational properties in atomically precise graphene nanostructures.
Landscape of pathogenic mutations in premature ovarian insufficiency
Authors: Ke Hanni , Tang Shuyan , Guo Ting , Hou Dong , Jiao Xue , Li Shan , Luo Wei , Xu Bingying , Zhao Shidou , Li Guangyu , Zhang Xiaoxi , Xu Shuhua , Wang Lingbo , Wu Yanhua , Wang Jiucun , Zhang Feng , Qin Yingying , Jin Li , Chen Zi-Jiang
Published: February 2023

Premature ovarian insufficiency (POI) is a major cause of female infertility due to early loss of ovarian function. POI is a heterogeneous condition, and its molecular etiology is unclear. To identify genetic variants associated with POI, here we performed whole-exome sequencing in a cohort of 1,030 patients with POI. We detected 195 pathogenic/likely pathogenic variants in 59 known POI-causative genes, accounting for 193 (18.7%) cases. Association analyses comparing the POI cohort with a control cohort of 5,000 individuals without POI identified 20 further POI-associated genes with a significantly higher burden of loss-of-function variants. Functional annotations of these novel 20 genes indicated their involvement in ovarian development and function, including gonadogenesis (LGR4 and PRDM1), meiosis (CPEB1, KASH5, MCMDC2, MEIOSIN, NUP43, RFWD3, SHOC1, SLX4 and STRA8) and folliculogenesis and ovulation (ALOX12, BMP6, H1-8, HMMR, HSD17B1, MST1R, PPM1B, ZAR1 and ZP3). Cumulatively, pathogenic and likely pathogenic variants in known POI-causative and novel POI-associated genes contributed to 242 (23.5%) cases. Further genotype–phenotype correlation analyses indicated that genetic contribution was higher in cases with primary amenorrhea compared to that in cases with secondary amenorrhea. This study expands understanding of the genetic landscape underlying POI and presents insights that have the potential to improve the utility of diagnostic genetic screenings.
Building a knowledge graph to enable precision medicine
Authors: Chandak Payal , Huang Kexin , Zitnik Marinka
Published: February 2023

Developing personalized diagnostic strategies and targeted treatments requires a deep understanding of disease biology and the ability to dissect the relationship between molecular and genetic factors and their phenotypic consequences. However, such knowledge is fragmented across publications, non-standardized repositories, and evolving ontologies describing various scales of biological organization between genotypes and clinical phenotypes. Here, we present PrimeKG, a multimodal knowledge graph for precision medicine analyses. PrimeKG integrates 20 high-quality resources to describe 17,080 diseases with 4,050,249 relationships representing ten major biological scales, including disease-associated protein perturbations, biological processes and pathways, anatomical and phenotypic scales, and the entire range of approved drugs with their therapeutic action, considerably expanding previous efforts in disease-rooted knowledge graphs. PrimeKG contains an abundance of ‘indications’, ‘contradictions’, and ‘off-label use’ drug-disease edges that lack in other knowledge graphs and can support AI analyses of how drugs affect disease-associated networks. We supplement PrimeKG’s graph structure with language descriptions of clinical guidelines to enable multimodal analyses and provide instructions for continual updates of PrimeKG as new data become available.
A high-resolution gridded grazing dataset of grassland ecosystem on the Qinghai–Tibet Plateau in 1982–2015
Authors: Meng Nan , Wang Lijing , Qi Wenchao , Dai Xuhuan , Li Zuzheng , Yang Yanzheng , Li Ruonan , Ma Jinfeng , Zheng Hua
Published: February 2023

Grazing intensity, characterized by high spatial heterogeneity, is a vital parameter to accurately depict human disturbance and its effects on grassland ecosystems. Grazing census data provide useful county-scale information; however, they do not accurately delineate spatial heterogeneity within counties, and a high-resolution dataset is urgently needed. Therefore, we built a methodological framework combining the cross-scale feature extraction method and a random forest model to spatialize census data after fully considering four features affecting grazing, and produced a high-resolution gridded grazing dataset on the Qinghai–Tibet Plateau in 1982–2015. The proposed method (R2 = 0.80) exhibited 35.59% higher accuracy than the traditional method. Our dataset were highly consistent with census data (R2 of spatial accuracy = 0.96, NSE of temporal accuracy = 0.96) and field data (R2 of spatial accuracy = 0.77). Compared with public datasets, our dataset featured a higher temporal resolution (1982–2015) and spatial resolution (over two times higher). Thus, it has the potential to elucidate the spatiotemporal variation in human activities and guide the sustainable management of grassland ecosystem.
The less obvious effect of hosting the Olympics on sporting performance
Authors: Csurilla Gergely , Fertő Imre
Published: February 2023

Hosting the Olympics has long been claimed to bring a financial return on investment. When this cannot clearly demonstrated, the medal surplus associated with host status is usually highlighted. We investigate the magnitude of having a home advantage at the recent Summer Olympic Games (1996–2021) separately for each organising country and by gender. Beside the host effect, the ex-ante and post impact on the medal surplus is also investigated in the same way. We analyse this effect using three models at the level of total medals, and medals won by men, and by women. Because of the number of zero observation in the response variable, we employ a zero-inflated negative binomial estimator. Our results cast some doubt on the claim of a host effect of the Olympics: when we control for socioeconomic variables in the models, the host effect fades away. Any host effect is clearer for medals won by men. Ex-ante and post effects on host countries are detectable in some cases but also fade with the inclusion of control variables. Based on our results, the medal surplus associated with the hosting of the Olympics is less evident than reported in literature or public discourse.
Language combinations of multilinguals are reflected in their first-language knowledge and processing
Authors: Kepinska Olga , Caballero Jocelyn , Oliver Myriam , Marks Rebecca A. , Haft Stephanie L. , Zekelman Leo , Kovelman Ioulia , Uchikoshi Yuuko , Hoeft Fumiko
Published: February 2023

Consequences of multilingualism vary from offering cognitive benefits to poor educational and cognitive outcomes. One aspect of multilingualism that has not been systematically examined is the typology of multilinguals' languages: Do differences and similarities between languages multilinguals are exposed to contribute to the development of their cognition and brain? We investigated n = 162 5–6-year-olds with various language backgrounds on a monolingual-to-quintilingual continuum. Our results show that typological linguistic diversity can be related to expressive vocabulary knowledge in the dominant language. On neural level, it relates to brain activation patterns in (among others) the PGa area in the bilateral IPL, a brain region previously associated with multilingual experience, but never with language typology. We propose an ecologically valid way of describing the continuum of multilingual language experience and provide evidence for both the cognition and the brain of multilingual kindergartners to be related to the typological linguistic diversity of their environment.
A secure and dependable trust assessment (SDTS) scheme for industrial communication networks
Authors: Khan Tayyab , Singh Karan , Ahmad Khaleel , Ahmad Khairol Amali Bin
Published: February 2023

Due to tamper-resistant sensor nodes and wireless media, Industrial Wireless Sensor Networks (WSNs) are susceptible to various security threats that severely affect industrial/business applications. The survival of sensor networks is highly dependent on the flourishing collaboration of sensor nodes. Trust management schemes seem to be realistic and promising techniques to improve security as well as cooperation (dependability) among sensor nodes by estimating the trust level (score) of individual sensor nodes. This research paper presents a well-organized and motivating secure, dependable trust assessment (SDTS) scheme for industrial WSNs to cope with unexpected behavior such as an on–off attack, bad-mouthing attack, garnished attack, etc., by employing robust trust evaluation components based on success ratio and node misbehaviour. SDTS incorporates an interesting trust evaluation function in which the trust range can be adjusted in accordance with the application requirement. SDTS include direct communication trust, indirect communication trust, data trust, and misbehavior-based trust to defend the multiple internal attacks. SDTS works according to the behavior of nodes, i.e., whether the sensor nodes are interacting frequently or not. Moreover, abnormal attenuation and dynamic slide lengths are incorporated in the proposed model (SDTS) to deal with various natural calamities and internal attacks. SDTS is compared against three recent state-of-the-art methods and found efficient in terms of ease of trust assessment, false-positive rate (2.5%), false-negative rate (2%), attack detection rate (90%), detection accuracy (91%), average energy consumption (0.40 J), and throughput (108 Kbps) under the load of 500 sensor nodes with 50% malicious nodes. Investigational results exhibit the potency of the proposed scheme.
Quantitative monitoring and modelling of retrodialysis drug delivery in a brain phantom
Authors: Rognin Etienne , Willis-Fox Niamh , Daly Ronan
Published: February 2023

A vast number of drug molecules are unable to cross the blood-brain barrier, which results in a loss of therapeutic opportunities when these molecules are administered by intravenous infusion. To circumvent the blood-brain barrier, local drug delivery devices have been developed over the past few decades such as reverse microdialysis. Reverse microdialysis (or retrodialysis) offers many advantages, such as a lack of net volume influx to the intracranial cavity and the ability to sample the tumour’s micro-environment. However, the translation of this technique to efficient drug delivery has not been systematically studied. In this work, we present an experimental platform to evaluate the performance of microdialysis devices in reverse mode in a brain tissue phantom. The mass of model drug delivered is measured by computing absorbance fields from optical images. Concentration maps are reconstructed using a modern and open-source implementation of the inverse Abel transform. To illustrate our method, we assess the capability of a commercial probe in delivering methylene blue to a gel phantom. We find that the delivery rate can be described by classical microdialysis theory, except at low dialysate flow rates where it is impacted by gravity, and high flow rates where significant convection to the gel occurs. We also show that the flow rate has an important impact not only on the overall size of the drug plume, but also on its shape. The numerical tools developed for this study have been made freely available to ensure that the method presented can be used to rapidly and inexpensively optimise probe design and protocol parameters before proceeding to more in-depth studies.
Novel versatile topologies and design optimization of wide-bandstop frequency selective surfaces for X-band, Ku-band and millimeter-wave applications
Authors: Aziz Rao Shahid , Koziel Slawomir , Leifsson Leifur , Szczepanski Stanislaw
Published: February 2023

Novel designs of frequency selective surface (FSS) are presented for wideband applications in X, Ku and mmWave (millimeter Wave) bands. Two identical metallic layers of FSS are imprinted on both sides of the RO4003 substrate. The geometry parameters are optimized to maximize the bandstop at the specified in-band maximum transmission level of −10 dB; satisfaction of the latter condition is enforced through appropriate formulation and handling of the design constraints. The proposed structure is versatile and can be readily re-designed for various operating bands. For the sake of illustration, two instances of the FSS were developed. Design 1 exhibits broad bandstop of 9.8 GHz at the X- and Ku-bands, whereas the bandstop of Design 2 is 33.5 GHz at the mmWave band. The two FSS unit cell designs share the same base topology, but specific dimensions are adjusted to operate within the lower and the higher bands, respectively. The unit cell is symmetrical, therefore, ensures an excellent resonance stability performance with respect to different polarizations (TE and TM) and incidence angles. For proof of concept only FSS Design 1 is fabricated and measured in an anechoic chamber. The simulated and measured results exhibit good agreement. Extensive benchmarking against state-of-the-art FSS designs from the literature corroborates the advantages of the proposed topology in terms of design novelty, topological versatility, compact size, and wide bandstop response as compared to the previously available designs.