bluuebunny/crossref_metadata_2025 huggingface dataset:
Algo-Functional Indexes and Spatiotemporal Parameters of Gait after Sacroiliac Joint Arthrodesis
Authors: Busso Chiara , Cambursano Simone , Aprato Alessandro , Destefanis Cristina , Gianotti Agnese , Massazza Giuseppe , Massè Alessandro , Minetto Marco Alessandro
Published: September 2020

Aims of the study were to evaluate the reliability and validity of the Italian version of the Majeed and Iowa questionnaires and to investigate the long-term surgical outcomes following sacroiliac joint arthrodesis. Twenty one patients who underwent a sacroiliac joint arthrodesis and 21 healthy subjects were evaluated. The experimental procedure consisted of gait analysis and a physical activity assessment (in both groups) and of administration of outcome questionnaires and pain assessment (in the patient group). The Majeed and Iowa questionnaires showed excellent reliability, excellent (for the Majeed questionnaire) and good (for the Iowa questionnaire) construct validity, and poor convergent validity (for both questionnaires) relative to walking speed. Most of the patients reported no pain and minimum pain-related disability and their physical activity profile was comparable to healthy controls. Patients showed an impaired walking performance (i.e., they walked slower and using shorter steps) compared with healthy controls. Long-term walking pattern abnormalities following sacroiliac joint arthrodesis may occur despite excellent clinical results. Given their excellent reliability and construct validity, the Majeed and Iowa questionnaires can be used in combination with the assessment of spatiotemporal gait parameters for the prognostic assessment and/or follow-up of surgical patients.
Mechanisms of Origin and Classification of Out-of-Plane Fiber Waviness in Composite Materials—A Review
Authors: Thor Michael , Sause Markus G. R. , Hinterhölzl Roland M.
Published: September 2020

Out-of-plane fiber waviness, also referred to as wrinkling, is considered one of the most significant effects that occur in composite materials. It significantly affects mechanical properties, such as stiffness, strength and fatigue and; therefore, dramatically reduces the load-carrying capacity of the material. Fiber waviness is inherent to various manufacturing processes of fiber-reinforced composite parts. They cannot be completely avoided and thus have to be tolerated and considered as an integral part of the structure. Because of this influenceable but in many cases unavoidable nature of fiber waviness, it might be more appropriate to consider fiber waviness as effects or features rather than defects. Hence, it is important to understand the impact of different process parameters on the formation of fiber waviness in order to reduce or, in the best case, completely avoid them as early as possible in the product and process development phases. Mostly depending on the chosen geometry of the part and the specific manufacturing process used, different types of fiber waviness result. In this study, various types of waviness are investigated and a classification scheme is developed for categorization purposes. Numerous mechanisms of wrinkling were analyzed, leading to several recommendations to prevent wrinkle formation, not only during composite processing, but also at an earlier design stage, where generally several influence factors are defined.
Beneficial Effects of Physical Activity in Diabetic Patients
Authors: Cannata Francesca , Vadalà Gianluca , Russo Fabrizio , Papalia Rocco , Napoli Nicola , Pozzilli Paolo
Published: September 2020

One of the main goals of diabetic therapy is to achieve the best metabolic control to prevent the development and progression of potential complications. A multidisciplinary approach characterized by the combination of diet, physical activity (PA) and drug therapy with oral and injectable (non-insulin) pharmacological agents, is desirable to optimize metabolic control. The aim of this review is to explain the contribution of PA and its beneficial effects on patients affected by type 1 (T1D) and type 2 diabetes (T2D). We provide an overview of evidence on the effects of PA for the main two types of diabetes mellitus (DM) to identify the right level of PA to be recommended. We discuss the physiological and clinical role of PA in people with DM. It can be concluded that the objective of antidiabetic therapy should be the achievement and optimization of metabolic control through a multidisciplinary approach involving non-pharmacological therapy such as diet and PA, which has a crucial role.
Object-Based Modeling of Marine Phytoplankton and Seaweeds
Authors: Vasechkina Elena
Published: September 2020

The aim of this work is to simulate the dissolved oxygen deficiency in the coastal zone that sometimes occurs during the summer water stagnation. We consider the main components of the marine ecosystem that play a major role in such processes—concentrations of nitrogen, phosphorus and sulfur compounds in water, dissolved and particular organic matter, oxygen, biomass of phytoplankton and macroalgae. We use the object-based modeling technique to simulate the spatio-temporal variability of the ecosystem in a 2D domain. In comparison with the traditional approach, it gives several advantages: more precise parametrizations of the biological components’ functionality; higher spatial resolution; possibility to account for the individual variability of hydrobionts; easy inclusion of an arbitrary number of species in the model. Our model included three species of phytoplankton and seven macroalgae. Individual-based modules control their functionality. Species of phytoplankton and seaweeds chosen for simulations are typical for the coastal zone of Crimea. In the simulations, we study the contribution of micro- and macroalgae to the processes of self-purification of a semi-enclosed basin in case of a sharp increase in nutrient concentration in water.
A Numerical Study on Roughness-Induced Adhesion Enhancement in a Sphere with an Axisymmetric Sinusoidal Waviness Using Lennard–Jones Interaction Law
Authors: Papangelo Antonio , Ciavarella Michele
Published: September 2020

Usually, roughness destroys adhesion and this is one of the reasons why the “adhesion paradox”, i.e., a “sticky Universe”, is not real. However, at least with some special type of roughness, there is even the case of adhesion enhancement, as it was shown clearly by Guduru, who considered the contact between a sphere and a wavy axisymmetric single scale roughness, in the limit of short-range adhesion (JKR limit). Here, the Guduru’s problem is numerically solved by using the Boundary Element Method (BEM) with Lennard–Jones interaction law, which allowed us to explore the contact solution from the rigid to the JKR limit. It is shown that adhesion enhancement stops either for low Tabor parameter, or by large waviness amplitudes, due to the appearance of internal cracks within the contact patch. We do not seem to find a clear threshold for “stickiness” (complete elimination of adhesion), contrary to other recent theories on random roughness. The enhancement effect is well captured by an equation in terms of the Johnson parameter derived by Ciavarella–Kesari–Lew, and is much larger than the Persson–Tosatti enhancement in terms of increase of real contact area due to roughness. The Persson–Tosatti energetic argument for adhesion reduction seems to give a lower bound to the effective work of adhesion.
Long-Term Prognosis of Endodontic Microsurgery—A Systematic Review and Meta-Analysis
Authors: Pinto Diogo , Marques Andréa , Pereira Joana F. , Palma Paulo J. , Santos João Miguel
Published: September 2020

Background and objectives: The long-term outcome of endodontic microsurgery (EMS) performed on root-filled teeth affected by post-treatment apical periodontitis (AP) has been a matter of debate, re-launched by the introduction of novel root-end filling materials which have been proven to improve the short-term outcome of EMS. The purpose of this systematic review and meta-analysis is to evaluate the clinical and radiographic long-term outcome of endodontic microsurgery in teeth diagnosed with secondary AP through radiographic evaluation. Materials and Methods: This systematic review and meta-analysis followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Inclusion and exclusion criteria were defined a priori to select the best longitudinal evidence. Only randomized clinical trials (RCT) and prospective clinical studies (PCS), with a follow-up ≥ 2-year, and exhibiting well-established clinical and radiographic outcome criteria, were selected. Results: A total of 573 articles were obtained, from which 10 fulfill inclusion criteria: 6 PCS and 4 RCT. Meta-analysis showed a pooled proportion of success rate of 91.3%, from an overall amount of 453 treated teeth included in RCT; from overall 839 included teeth in PCS, a pooled success rate of 78.4% was observed, with the follow-up time ranging from 2 to 13-years. Survival rate outcomes varied from 79 to 100% for the same follow-up period. Five prognostic factors with influence on the outcome were disclosed: smoking habits, tooth location and type, absence/presence of dentinal defects, interproximal bone level, and root-end filling material. Conclusions: High success rates and predictable results can be expected when EMS is performed by trained endodontists, allowing good prognosis and preservation of teeth affected by secondary AP.
1,25-Dihydroxyvitamin D3 Inhibits Lipopolysaccharide-Induced Interleukin-6 Production by C2C12 Myotubes
Authors: Nonaka Koji , Akiyama Junichi , Yoshikawa Yoshiyuki , Une Satsuki , Ito Kenichi
Published: September 2020

Background and Objective. 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) inhibits proinflammatory cytokines in microglial cells and monocytes. However, it is unclear whether 1,25(OH)2D3 inhibits proinflammatory cytokines in muscle cells. This study was conducted to investigate whether 1,25(OH)2D3 inhibits the production of proinflammatory cytokines, resulting in inhibition of the protein expression of E3 ubiquitin ligases and muscle protein loss. Materials and Methods. C2C12 myoblasts were proliferated in Dulbecco’s modified Eagle medium (DMEM) containing 10% fetal bovine serum, and myoblasts were differentiated into myotubes in DMEM containing 2% horse serum. Myotubes were treated with 1,25(OH)2D3 for 24 h, followed by lipopolysaccharide (LPS) stimulation for 48 h. Results. Interleukin (IL)-6 protein concentrations were higher in the culture supernatant following LPS stimulation compared to that without LPS stimulation (p < 0.001). However, the IL-6 concentration was significantly lower in C2C12 myotubes following 1,25(OH)2D3 treatment than in C2C12 myotubes without 1,25(OH)2D3 treatment (p < 0.001). The myosin heavy chain (MHC), muscle atrophy F-box, and muscle ring-finger protein-1 protein levels did not significantly differ (P = 0.324, 0.552, and 0.352, respectively). We could not compare tumor necrosis factor α (TNFα) protein levels because they were below the limit of detection of our assay in many supernatant samples, including in LPS-stimulated samples. Conclusions. 1,25(OH)2D3 inhibited increases in IL-6 protein concentrations in muscle cells stimulated by LPS, suggesting that 1,25(OH)2D3 inhibits inflammation in muscle cells. The findings suggest that 1,25(OH)2D3 can prevent or improve sarcopenia, which is associated with IL-6. The TNFα protein content could not be measured, and MHC was not decreased despite LPS stimulation of C2C12 myotubes. Further studies are needed to examine the effects of higher doses of LPS stimulation on muscle cells and use more sensitive methods for measuring TNFα protein to investigate the preventive effects of 1,25(OH)2D3 on increased TNFα and muscle proteolysis.
Evolution of Microstructure, Texture, and Mechanical Properties of As-Extruded ND/ZK60 Composite during Hot Compression Deformation
Authors: Wang Jinhui , Li Shangpeng , Ma Hongbin
Published: September 2020

The effects of temperature, strain rate, and strain on the microstructure, texture, and mechanical properties of as-extruded nanodiamond reinforced ZK60 composite during hot compression was systematically studied. The results revealed that the precipitating MgZn2 and the nanodiamond (ND) particles distributed in the grain interiors hindered the motion of dislocations. The ND particles act as nucleation points and promote the dynamic recrystallization (DRX) of the composites during the hot compression deformation, the flow stress of ND/ZK60 increases with strain rate increases and temperature decreases. {101¯2} extension twins are nucleated and grown in the coarse grains as the compressive strain increasing. Meanwhile, the fine grains of DRX generate and present first an increasing then a decreasing trend. The result of Schmid factor and kernel average misorientation indicates that high-density dislocation caused by dislocation climbing and cross slip aggregated in composites with increasing strain. Therefore, the work hardening trend of the composite is strengthened.
Modulating Wine Aromatic Amino Acid Catabolites by Using Torulaspora delbrueckii in Sequentially Inoculated Fermentations or Saccharomyces cerevisiae Alone
Authors: Álvarez-Fernández M. Antonia , Carafa Ilaria , Vrhovsek Urska , Arapitsas Panagiotis
Published: September 2020

Yeasts are the key microorganisms that transform grape juice into wine, and nitrogen is an essential nutrient able to affect yeast cell growth, fermentation kinetics and wine quality. In this work, we focused on the intra- and extracellular metabolomic changes of three aromatic amino acids (tryptophan, tyrosine, and phenylalanine) during alcoholic fermentation of two grape musts by two Saccharomyces cerevisiae strains and the sequential inoculation of Torulaspora delbrueckii with Saccharomyces cerevisiae. An UPLC-MS/MS method was used to monitor 33 metabolites, and 26 of them were detected in the extracellular samples and 8 were detected in the intracellular ones. The results indicate that the most intensive metabolomic changes occurred during the logarithm cellular growth phase and that pure S. cerevisiae fermentations produced higher amounts of N-acetyl derivatives of tryptophan and tyrosine and the off-odour molecule 2-aminoacetophenone. The sequentially inoculated fermentations showed a slower evolution and a higher production of metabolites linked to the well-known plant hormone indole acetic acid (auxin). Finally, the production of sulfonated tryptophol during must fermentation was confirmed, which also may explain the bitter taste of wines produced by Torulaspora delbrueckii co-fermentations, while sulfonated indole carboxylic acid was detected for the first time in such an experimental design.
Impact of Ozone, Sex, and Gonadal Hormones on Bronchoalveolar Lavage Characteristics and Survival in SP-A KO Mice Infected with Klebsiella pneumoniae
Authors: Gandhi Chintan K. , Mikerov Anatoly N. , Durrani Faryal , Umstead Todd M. , Hu Sanmei , Wang Guirong , Phelps David S. , Floros Joanna
Published: September 2020

Surfactant protein A (SP-A) plays an important role in innate immunity. The sex-dependent survival of infected SP-A knockout (KO) mice has been observed. Our goal was to study the impact of ozone (O3) and sex, as well as gonadal hormones, on the bronchoalveolar lavage (BAL) readouts and survival, respectively, of Klebsiella pneumoniae-infected SP-A KO mice. Male and female SP-A KO mice were exposed to O3 or filtered air and infected with K. pneumoniae. We studied markers of inflammation and tissue damage at 4, 24, and 48 h, as well as the survival over 14 days, of gonadectomized (Gx) mice implanted with control pellets (CoP) or hormone (5α-dihydrotestosterone (DHT) in female gonadectomized mice (GxF) or 17β-estradiol (E2) in male gonadectomized mice (GxM)). We observed: (1) an increase in neutrophil and macrophage inflammatory protein-2 levels as time progressed post-infection, and O3 exposure appeared to increase this response; (2) an increase in lactate dehydrogenase, total protein, oxidized protein, and phospholipids in response to O3 with no consistent sex differences in studied parameters; and (3) a reduction in survival of the GxM and CoP mice, the GxM and E2 mice, and the GxF and DHT mice but not for the GxF and CoP mice after O3. Without SP-A, (a) sex was found to have a minimal impact on BAL cellular composition and tissue damage markers, and (b) the impact of gonadal hormones on survival was found to involve different mechanisms than in the presence of SP-A.
Epidemiology of Cryptosporidiosis in France from 2017 to 2019
Authors: Costa Damien , Razakandrainibe Romy , Valot Stéphane , Vannier Margot , Sautour Marc , Basmaciyan Louise , Gargala Gilles , Viller Venceslas , Lemeteil Denis , Ballet Jean-Jacques ,   French National Network on Surveillance of Human Cryptosporidiosis, Dalle Frédéric , Favennec Loïc
Published: September 2020

Cryptosporidiosis is currently recognized worldwide as a leading cause of moderate to severe diarrhea. In Europe, large water- and foodborne outbreaks have been reported, highlighting the widespread distribution of the parasite and its important health impact. Surveillance networks have been progressively set up and the aim of this study was to present recent epidemiological data obtained in France from 2017 to 2019 by the National Reference Center—Expert Laboratory of cryptosporidiosis (Centre National de Référence–Laboratoire Expert cryptosporidioses CNR-LE). Data were obtained from online reports of volunteer network participants and stools were sent to the CNR-LE for species identification and GP60 genotyping. During this period, data from 750 online reports were available. Cryptosporidiosis occurred predominantly in young children (<5 years old) and in young adults, especially during late summer. Most patients were immunocompetent (60%), and deaths were reported only in immunocompromised patients. Cryptosporidium parvum was largely predominant (72% of cases) over C. hominis (24%) and some other uncommon species. C. parvum GP60 subtypes IIa and IId were the most represented, which suggests frequent zoonotic transmission. For C. hominis, subtypes IbA10G2 and IaA22R2 were predominant.
Nanocellulose Hybrids with Metal Oxides Nanoparticles for Biomedical Applications
Authors: Oprea Madalina , Panaitescu Denis Mihaela
Published: September 2020

Cellulose is one of the most affordable, sustainable and renewable resources, and has attracted much attention especially in the form of nanocellulose. Bacterial cellulose, cellulose nanocrystals or nanofibers may serve as a polymer support to enhance the effectiveness of metal nanoparticles. The resultant hybrids are valuable materials for biomedical applications due to the novel optical, electronic, magnetic and antibacterial properties. In the present review, the preparation methods, properties and application of nanocellulose hybrids with different metal oxides nanoparticles such as zinc oxide, titanium dioxide, copper oxide, magnesium oxide or magnetite are thoroughly discussed. Nanocellulose-metal oxides antibacterial formulations are preferred to antibiotics due to the lack of microbial resistance, which is the main cause for the antibiotics failure to cure infections. Metal oxide nanoparticles may be separately synthesized and added to nanocellulose (ex situ processes) or they can be synthesized using nanocellulose as a template (in situ processes). In the latter case, the precursor is trapped inside the nanocellulose network and then reduced to the metal oxide. The influence of the synthesis methods and conditions on the thermal and mechanical properties, along with the bactericidal and cytotoxicity responses of nanocellulose-metal oxides hybrids were mainly analyzed in this review. The current status of research in the field and future perspectives were also signaled.
Flame-Retardant Systems Based on Chitosan and Its Derivatives: State of the Art and Perspectives
Authors: Malucelli Giulio
Published: September 2020

During the last decade, the utilization of chitin, and in par0ticular its deacetylated form, i.e., chitosan, for flame retardant purposes, has represented quite a novel and interesting application, very far from the established uses of this bio-sourced material. In this context, chitosan is a carbon source that can be successfully exploited, often in combination with intumescent products, in order to provide different polymer systems (namely, bulky materials, fabrics and foams) with high flame retardant (FR) features. Besides, this specific use of chitosan in flame retardance is well suited to a green and sustainable approach. This review aims to summarize the recent advances concerning the utilization of chitosan as a key component in the design of efficient flame retardant systems for different polymeric materials.
Reducing the Competition: A Dual-Purpose Ionic Liquid for the Extraction of Gallium from Iron Chloride Solutions
Authors: M. M. Kinsman Luke , A. Morrison Carole , T. Ngwenya Bryne , B. Love Jason
Published: September 2020

The separation of gallium from iron by solvent extraction from chloride media is challenging because the anionic chloridometalates, FeCl4− and GaCl4−, display similar chemical properties. However, we report here that the selective separation of gallium from iron in HCl solution can be achieved using the dual-purpose ionic liquid methyltrioctylammonium iodide in a solvent extraction process. In this case, the reduction of Fe3+ to Fe2+ by the iodide counterion was found to inhibit Fe transport, facilitating quantitative Ga extraction by the ionic liquid with minimal Fe extraction from 2 M HCl.
Biomass-Derived Porous Carbons Derived from Soybean Residues for High Performance Solid State Supercapacitors
Authors: Chung Hsiu-Ying , Pan Guan-Ting , Hong Zhong-Yun , Hsu Chun-Tsung , Chong Siewhui , Yang Thomas Chung-Kuang , Huang Chao-Ming
Published: September 2020

A series of heteroatom-containing porous carbons with high surface area and hierarchical porosity were successfully prepared by hydrothermal, chemical activation, and carbonization processes from soybean residues. The initial concentration of soybean residues has a significant impact on the textural and surface functional properties of the obtained biomass-derived porous carbons (BDPCs). SRAC5 sample with a BET surface area of 1945 m2 g−1 and a wide micro/mesopore size distribution, nitrogen content of 3.8 at %, and oxygen content of 15.8 at % presents the best electrochemical performance, reaching 489 F g−1 at 1 A g−1 in 6 M LiNO3 aqueous solution. A solid-state symmetric supercapacitor (SSC) device delivers a specific capacitance of 123 F g−1 at 1 A g−1 and a high energy density of 68.2 Wh kg−1 at a power density of 1 kW kg−1 with a wide voltage window of 2.0 V and maintains good cycling stability of 89.9% capacitance retention at 2A g−1 (over 5000 cycles). The outstanding electrochemical performances are ascribed to the synergistic effects of the high specific surface area, appropriate pore distribution, favorable heteroatom functional groups, and suitable electrolyte, which facilitates electrical double-layer and pseudocapacitive mechanisms for power and energy storage, respectively.
Photocatalytic Degradation and Antibacterial Properties of Fe3+-Doped Alkalized Carbon Nitride
Authors: Gao Ying , Duan Jizhou , Zhai Xiaofan , Guan Fang , Wang Xiutong , Zhang Jie , Hou Baorong
Published: September 2020

Discovering novel materials and improving the properties of existing materials are the main goals in the field of photocatalysis to increase the potential application of the materials. In this paper, a modified graphitic carbon nitride (g-C3N4) photocatalyst named Fe3+-doped alkalized carbon nitride, which couples the photocatalytic reaction with the Fenton reaction, is introduced to demonstrate its Rhodamine B (RhB) degradation and antibacterial properties. Under visible-light irradiation, the degradation rate of RhB was 99.9% after 200 min, while the antibacterial rates of Pseudomonas aeruginosa (P. aeruginosa), Escherichia coli (E. coli), and Staphylococcus aureus (S. aureus) after 300 min were 99.9986%, 99.9974%, and 99.9876%, respectively. Moreover, the repetitive experiments of RhB degradation demonstrate that the proposed photocatalysts have excellent stability and reusability. The active free radical trapping experiments reveal that the superoxide radical (·O2−) is the dominant reactive oxygen species. In addition, the Fenton reaction is introduced into the photocatalytic system due to the doping of Fe3+, and the hydroxyl radical (·OH) produced from the Fenton reaction further enhances the photocatalytic performance. The remarkable improvement in photocatalytic performance of the proposed photocatalyst can be attributed to its broader UV–visible absorption characteristic and the occurrence of the Fenton reaction.
Chitosan Nanofiber and Cellulose Nanofiber Blended Composite Applicable for Active Food Packaging
Authors: Hai Le Van , Zhai Lindong , Kim Hyun Chan , Panicker Pooja S. , Pham Duc Hoa , Kim Jaehwan
Published: September 2020

This paper reports that, by simply blending two heterogeneous polysaccharide nanofibers, namely chitosan nanofiber (ChNF) and cellulose nanofiber (CNF), a ChNF–CNF composite was prepared, which exhibited improved mechanical properties and antioxidant activity. ChNF was isolated using the aqueous counter collision (ACC) method, while CNF was isolated using the combination of TEMPO oxidation and the ACC method, which resulted in smaller size of CNF than that of ChNF. The prepared composite was characterized in terms of morphologies, FT-IR, UV visible, thermal stability, mechanical properties, hygroscopic behaviors, and antioxidant activity. The composite was flexible enough to be bent without cracking. Better UV-light protection was shown at higher content of ChNF in the composite. The high ChNF content showed the highest antioxidant activity in the composite. It is the first time that a simple combination of ChNF–CNF composites fabrication showed good mechanical properties and antioxidant activities. In this study, the reinforcement effect of the composite was addressed. The ChNF–CNF composite is promising for active food packaging application.
Effects of Maternal Fish Oil and/or 5-Methyl-Tetrahydrofolate Supplementation during Pregnancy on Offspring Brain Resting-State at 10 Years Old: A Follow-Up Study from the NUHEAL Randomized Controlled Trial
Authors: Azaryah Hatim , Verdejo-Román Juan , Martin-Pérez Cristina , García-Santos José Antonio , Martínez-Zaldívar Cristina , Torres-Espínola Francisco J. , Campos Daniel , Koletzko Berthold , Pérez-García Miguel , Catena Andrés , Campoy Cristina
Published: September 2020

Recent studies have shown that maternal supplementation with folate and long-chain polyunsaturated fatty acids (LC-PUFAs) during pregnancy may affect children’s brain development. We aimed at examining the potential long-term effect of maternal supplementation with fish oil (FO) and/or 5-methyl-tetrahydrofolate (5-MTHF) on the brain functionality of offspring at the age of 9.5–10 years. The current study was conducted as a follow-up of the Spanish participants belonging to the Nutraceuticals for a Healthier Life (NUHEAL) project; 57 children were divided into groups according to mother’s supplementation and assessed through functional magnetic resonance imaging (fMRI) scanning and neurodevelopment testing. Independent component analysis and double regression methods were implemented to investigate plausible associations. Children born to mothers supplemented with FO (FO and FO + 5-MTHF groups, n = 33) showed weaker functional connectivity in the default mode (DM) (angular gyrus), the sensorimotor (SM) (motor and somatosensory cortices) and the fronto-parietal (FP) (angular gyrus) networks compared to the No-FO group (placebo and 5-MTHF groups, n = 24) (PFWE < 0.05). Furthermore, no differences were found regarding the neuropsychological tests, except for a trend of better results in an object recall (memory) test. Considering the No-FO group, the aforementioned networks were associated negatively with attention and speed-processing functions. Mother’s FO supplementation during pregnancy seems to be able to shape resting-state network functioning in their children at school age and appears to produce long-term effects on children´s cognitive processing.
Mechanisms of CYP450 Inhibition: Understanding Drug-Drug Interactions Due to Mechanism-Based Inhibition in Clinical Practice
Authors: Deodhar Malavika , Al Rihani Sweilem B , Arwood Meghan J. , Darakjian Lucy , Dow Pamela , Turgeon Jacques , Michaud Veronique
Published: September 2020

In an ageing society, polypharmacy has become a major public health and economic issue. Overuse of medications, especially in patients with chronic diseases, carries major health risks. One common consequence of polypharmacy is the increased emergence of adverse drug events, mainly from drug–drug interactions. The majority of currently available drugs are metabolized by CYP450 enzymes. Interactions due to shared CYP450-mediated metabolic pathways for two or more drugs are frequent, especially through reversible or irreversible CYP450 inhibition. The magnitude of these interactions depends on several factors, including varying affinity and concentration of substrates, time delay between the administration of the drugs, and mechanisms of CYP450 inhibition. Various types of CYP450 inhibition (competitive, non-competitive, mechanism-based) have been observed clinically, and interactions of these types require a distinct clinical management strategy. This review focuses on mechanism-based inhibition, which occurs when a substrate forms a reactive intermediate, creating a stable enzyme–intermediate complex that irreversibly reduces enzyme activity. This type of inhibition can cause interactions with drugs such as omeprazole, paroxetine, macrolide antibiotics, or mirabegron. A good understanding of mechanism-based inhibition and proper clinical management is needed by clinicians when such drugs are prescribed. It is important to recognize mechanism-based inhibition since it cannot be prevented by separating the time of administration of the interacting drugs. Here, we provide a comprehensive overview of the different types of mechanism-based inhibition, along with illustrative examples of how mechanism-based inhibition might affect prescribing and clinical behaviors.
Zinc-lysine Supplementation Mitigates Oxidative Stress in Rapeseed (Brassica napus L.) by Preventing Phytotoxicity of Chromium, When Irrigated with Tannery Wastewater
Authors: Zaheer Ihsan Elahi , Ali Shafaqat , Saleem Muhammad Hamzah , Arslan Ashraf Muhammad , Ali Qurban , Abbas Zohaib , Rizwan Muhammad , El-Sheikh Mohamed A. , Alyemeni Mohammed Nasser , Wijaya Leonard
Published: September 2020

Contamination of soil and water with metals and metalloids is one of the most serious problems worldwide due to a lack of a healthy diet and food scarcity. Moreover, the cultivation of oilseed crops such as rapeseed (Brassica napus L.) with tannery wastewater could contain a large amount of toxic heavy metals [e.g., chromium (Cr)], which ultimately reduce its yield and directly influence oilseed quality. To overcome Cr toxicity in B. napus, a pot experiment was conducted to enhance plant growth and biomass by using newly introduced role of micronutrient-amino chelates [Zinc-lysine (Zn-lys)], which was irrigated with different levels [0% (control), 33%, 66%, and 100%] of tannery wastewater. According to the results of present findings, very high content of Cr in the wastewater directly affected plant growth and composition as well as gas exchange parameters, while boosting up the production of reactive oxygen species (ROS) and induced oxidative damage in the roots and leaves of B. napus. However, activities of antioxidants initially increased (33% of wastewater), but further addition of tannery wastewater in the soil caused a decrease in antioxidant enzymes, which also manifested by Zn content, while the conscious addition of wastewater significantly increased Cr content in the roots and shoots of B. napus. To reduce Cr toxicity in B. napus plants, exogenous supplementation of Zn-lys (10 mg/L) plays an effective role in increasing morpho-physiological attributes of B. napus and also reduces the oxidative stress in the roots and leaves of the oilseed crop (B. napus). Enhancement in different growth attributes was directly linked with increased in antioxidative enzymes while decreased uptake and accumulation of Cr content in B. napus when cultivated in wastewater with the application of Zn-lys. Zn-lys, therefore, plays a protective role in reducing the Cr toxicity of B. napus through an increase in plant growth and lowering of Cr uptake in various plant organs. However, further studies at field levels are required to explore the mechanisms of Zn–lys mediated reduction of Cr and possibly other heavy metal toxicity in plants.
Composite Nafion-CaTiO3-δ Membranes as Electrolyte Component for PEM Fuel Cells
Authors: Mazzapioda Lucia , Lo Vecchio Carmelo , Danyliv Olesia , Baglio Vincenzo , Martinelli Anna , Navarra Maria Assunta
Published: September 2020

Manufacturing new electrolytes with high ionic conductivity has been a crucial challenge in the development and large-scale distribution of fuel cell devices. In this work, we present two Nafion composite membranes containing a non-stoichiometric calcium titanate perovskite (CaTiO3−δ) as a filler. These membranes are proposed as a proton exchange electrolyte for Polymer Electrolyte Membrane (PEM) fuel cell devices. More precisely, two different perovskite concentrations of 5 wt% and 10 wt%, with respect to Nafion, are considered. The structural, morphological, and chemical properties of the composite membranes are studied, revealing an inhomogeneous distribution of the filler within the polymer matrix. Direct methanol fuel cell (DMFC) tests, at 110 °C and 2 M methanol concentration, were also performed. It was observed that the membrane containing 5 wt% of the additive allows the highest cell performance in comparison to the other samples, with a maximum power density of about 70 mW cm−2 at 200 mA cm−2. Consequently, the ability of the perovskite structure to support proton carriers is here confirmed, suggesting an interesting strategy to obtain successful materials for electrochemical devices.
Long-Period Fiber Grating Sensor Based on a Conductive Polymer Functional Layer
Authors: Hsu Ching-Yu , Chiang Chia-Chin , Wen Hsin-Yi , Weng Jian-Jie , Chen Jing-Lun , Chen Tao-Hsing , Chen Ya-Hui
Published: September 2020

A temperature sensor was fabricated with a functional conductive poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) coating on a long-period fiber grating (LPFG). The LPFG was fabricated by laser-assisted wet-chemical etching for controlling the grating depth of the LPFG after the treated surface of an optical fiber was inscribed by laser light. The functional conductive polymer acts as a temperature sustained sensing layer and enhances the grating depth of the LPFG sensor as a strain buffer at various temperatures. The sensor was subjected to three cycles of temperature measurement to investigate the sensor’s wavelength shift and energy loss when exposed to temperatures between 30 and 100 °C. Results showed that the sensor’s average wavelength sensitivity and its linearity were 0.052 nm/°C and 99%, respectively; average transmission sensitivity and linearity were 0.048 (dB/°C) and 95%, respectively.
Microstructural Changes during Degradation of Biobased Poly(4-hydroxybutyrate) Sutures
Authors: Keridou Ina , Franco Lourdes , del Valle Luis J. , Martínez Juan C. , Funk Lutz , Turon Pau , Puiggalí Jordi
Published: September 2020

Fibers of poly(4-hydroxybutyrate) (P4HB) have been submitted to both hydrolytic and enzymatic degradation media in order to generate samples with different types and degrees of chain breakage. Random chain hydrolysis is clearly enhanced by varying temperatures from 37 to 55 °C and is slightly dependent on the pH of the medium. Enzymatic attack is a surface erosion process with significant solubilization as a consequence of a preferent stepwise degradation. Small angle X-ray diffraction studies revealed a peculiar supramolecular structure with two different types of lamellar stacks. These were caused by the distinct shear stresses that the core and the shell of the fiber suffered during the severe annealing process. External lamellae were characterized by surfaces tilted 45° with respect to the stretching direction and a higher thickness, while the inner lamellae were more imperfect and had their surfaces perpendicularly oriented to the fiber axis. In all cases, WAXD data indicated that the chain molecular axis was aligned with the fiber axis and molecules were arranged according to a single orthorhombic structure. A gradual change of the microstructure was observed as a function of the progress of hydrolysis while changes were not evident under an enzymatic attack. Hydrolysis mainly affected the inner lamellar stacks as revealed by the direct SAXS patterns and the analysis of correlation functions. Both lamellar crystalline and amorphous thicknesses slightly increased as well as the electronic contrast between amorphous and crystalline regions. Thermal treatments of samples exposed to the hydrolytic media revealed microstructural changes caused by degradation, with the inner lamellae being those that melted faster.
DA-CapsUNet: A Dual-Attention Capsule U-Net for Road Extraction from Remote Sensing Imagery
Authors: Ren Yongfeng , Yu Yongtao , Guan Haiyan
Published: September 2020

The up-to-date and information-accurate road database plays a significant role in many applications. Recently, with the improvement in image resolutions and quality, remote sensing images have provided an important data source for road extraction tasks. However, due to the topology variations, spectral diversities, and complex scenarios, it is still challenging to realize fully automated and highly accurate road extractions from remote sensing images. This paper proposes a novel dual-attention capsule U-Net (DA-CapsUNet) for road region extraction by combining the advantageous properties of capsule representations and the powerful features of attention mechanisms. By constructing a capsule U-Net architecture, the DA-CapsUNet can extract and fuse multiscale capsule features to recover a high-resolution and semantically strong feature representation. By designing the multiscale context-augmentation and two types of feature attention modules, the DA-CapsUNet can exploit multiscale contextual properties at a high-resolution perspective and generate an informative and class-specific feature encoding. Quantitative evaluations on a large dataset showed that the DA-CapsUNet provides a competitive road extraction performance with a precision of 0.9523, a recall of 0.9486, and an F-score of 0.9504, respectively. Comparative studies with eight recently developed deep learning methods also confirmed the applicability and superiority or compatibility of the DA-CapsUNet in road extraction tasks.
Nutrient Prediction for Tef (Eragrostis tef) Plant and Grain with Hyperspectral Data and Partial Least Squares Regression: Replicating Methods and Results across Environments
Authors: Flynn K. Colton , Frazier Amy E. , Admas Sintayehu
Published: September 2020

Achieving reproducibility and replication (R&R) of scientific results is tantamount for science to progress, and it is also necessary for ensuring the self-correcting mechanism of the scientific method. Topics of R&R have sailed to the forefront of research agenda in many fields recently but have received less attention in remote sensing in general and specifically for studies utilizing hyperspectral data. Given the extremely local environments in which many hyperspectral studies are conducted (e.g., agricultural field plots), purposeful attention to the repeatability of findings across study locales can help ensure methods are generalizable. This study undertakes an investigation of the nutrient content of tef (Eragrostis tef), an understudied plant that is growing in importance due to both food and forage benefits, but does so within the context of the replicability of methods and findings across two study sites situated in different international and environmental contexts. The aims are to (1) determine whether calcium, magnesium, and protein of both the plant and grain can be predicted using hyperspectral data with partial least squares (PLS) regression with waveband selection, and (2) compare the replicability of models across differing environments. Results suggest the method can produce high nutrient prediction accuracy for both the plant and grain in individual environments, but selection of wavebands for nutrient prediction was not comparable across study areas. The findings suggest that the method must be calibrated in each location, thereby reducing the potential to extrapolate methods to different areas. Our findings highlight the need for greater attention to methods and results replication in remote sensing, specifically hyperspectral analyses, in order for scientific findings to be repeatable beyond the plot level.
Biases Characteristics Assessment of the Advanced Geosynchronous Radiation Imager (AGRI) Measurement on Board Fengyun–4A Geostationary Satellite
Authors: Zhu Jia , Shu Jiong , Guo Wei
Published: September 2020

The Chinese Fengyun–4A geostationary meteorological satellite was successfully launched on 11 December 2016, carrying an Advanced Geostationary Radiation Imager (AGRI) to provide the observations of visible, near infrared, and infrared bands with improved spectral, spatial, and temporal resolution. The AGRI infrared observations can be assimilated into numerical weather prediction (NWP) data assimilation systems to improve the atmospheric analysis and weather forecasting capabilities. To achieve data assimilation, the first and crucial step is to characterize and evaluate the biases of the AGRI brightness temperatures in infrared channels 8–14. This study conducts the assessment of clear–sky AGRI full–disk infrared observation biases by coupling the RTTOV model and ERA Interim analysis. The AGRI observations are generally in good agreement with the model simulations. It is found that the biases over the ocean and land are less than 1.4 and 1.6 K, respectively. For bias difference between land and ocean, channels 11–13 are more obvious than water vapor channels 9–10. The fitting coefficient of linear regression tests between AGRI biases and sensor zenith angles manifests no obvious scan angle–dependent biases over ocean. All infrared channels observations are scene temperature–dependent over the ocean and land.
Analysis of Hospitality, Leisure, and Tourism Studies in Chile
Authors: Acevedo-Duque Ángel , Vega-Muñoz Alejandro , Salazar-Sepúlveda Guido
Published: September 2020

This article provides a scientific production overview of hospitality, leisure, and tourism studies in Chile, including key factors of interest regarding this social science subdiscipline. The fundamental knowledge contributions are examined using a scientometric approach (spatial, productive, of impact, and relational) based on data from records stored in the Web of Science (JCR and ESCI). This approach aims to critically analyze the scientific production on hospitality, leisure, and tourism (HLT) with contributions from authors affiliated with Chile, to respond to the connection between this research, the sectoral education, and sustainable development of the HLT industry. At the results level, an increase in scientific production in the last decade, a breadth revealed in publications’ quality terms, insertion in worldwide relevance co-authorship networks, an evolution from general issues to those of the discipline itself (cultural tourism, wine tourism, tourism marketing, hospitality industry, and sustainable tourism), a concentration on ecotourism education, and a disconnection between the diverse knowledge-producing centers and those of sectoral training were identified.
Improving Green Market Orientation, Green Supply Chain Relationship Quality, and Green Absorptive Capacity to Enhance Green Competitive Advantage in the Green Supply Chain
Authors: Lin Yu-Hsien , Kulangara Nisha , Foster Krista , Shang Jennifer
Published: September 2020

This study examines the influences of market orientation, supply chain relationship quality, and absorptive capacity on competitive advantage in green supply chains. We examine the intensity of these relationships in a green supply chain context. This study aims to figure out the effects of green market orientation (GMO), green supply chain relationship quality (GRQ), and green absorptive capacity (GAC) on green competitive advantage (GCA) in a supply chain. We find a significant positive association between these constructs. It highlights the importance of antecedents such as GMO, GRQ, and GAC on improving GCA. We jointly investigate the effects of GMO, GRQ, and GAC on green supply chain competitive advantage. This study uses Process Macro 2.15 to test the mediation effect between GMO and GCA. The result shows that GRQ and GAC completely mediate the relationship between GMO and GCA and that the effect sizes are 0.11 and 0.20, respectively. This study also reruns the model to clarify whether competing models are better than our model. However, the performance of such a competing model is poor. Finally, we accept our model instead of the competing model. GMO and GRQ among team managers and employees appear to contribute positively to GCA. Although GAC does not directly influence GCA, GMO has a significant total effect on GCA when intervened by GRQ and GAC. The key contribution is that green market orientation, i.e., the employee culture and the emphasis on being environmentally responsible, is a key antecedent to GRQ, GAC, and GCA. Managerial implications of the findings are listed.
Educating Digital Citizens: An Opportunity to Critical and Activist Perspective of Sustainable Development Goals
Authors: Lozano-Díaz Antonia , Fernández-Prados Juan S.
Published: September 2020

The 2030 Agenda sets out seventeen Sustainable Development Goals (SDGs). The educational goal is to promote the education of citizens on sustainable development, among other things. Educating today’s digital citizens on sustainability means training them for justice and social activism, commitment and political engagement. However, research into the subject shows a lack of consistency in the education of university students. This paper presents a study of students of Education, on education on sustainability through the practice of active and critical digital citizenship. A quasi-experimental method was used to learn about the behaviors of digital citizens, and intervention was carried out by means of an SDG-focused workshop and observation of the final level of commitment. The results show a positive level of commitment and digital activism around content related to sustainable development, which can be addressed from the university syllabus in a cross-curricular way.