bluuebunny/crossref_metadata_2025 huggingface dataset:
The experience of living with human immunodeficiency virus among adolescents at Felege Hiwot Comprehensive Specialized Hospital Bahir-Dar, Northwest Ethiopia, A phenomenological study
Authors: Guadie Bazezew Asfaw , Belete Minyichil Birhanu , Beyene Meseret Mekuriaw , Melese Ayalew Kassie , Tessema Tarik Yenew , Workineh Yinager
Published: January 2025

Background

Adolescents who have the human immunodeficiency virus face difficulties in their lives not just from the physical consequences of the illness but also from social stigma and discrimination. The quantitative side of this issue was the focus of earlier Ethiopian research. However, there hasn’t been any prior research done extensively in Ethiopia on the real-life experiences of teenagers infected with HIV. Therefore, in order to address the real issues that these teenagers encounter, it is imperative that we investigate their lived experiences as HIV-positive adolescents.

Objective

The goal is to investigate the experiences that adolescents at Felege Hiwot Comprehensive Specialized Hospital who are infected with HIV have on a daily basis.

Method

A phenomenological approach was conducted among thirteen purposively selected adolescents at Felege Hiwot Comprehensive Specialized Hospital, Bahir-Dar, northwest Ethiopia, from March 25 to April 30, 2023. Information saturation was used to estimate the sample size. Data was gathered through semi-structured open-ended interview guides and in-depth interview techniques. The talk was recorded using an audio recorder. The data was transcribed verbatim. The conceptual translation approach was used to translate the transcribed data from Amharic to English. For additional analysis, the translated data was entered into the Atlas.ti.8 program. To demonstrate findings, the inductive thematic analysis technique was applied using illustrative quotes. Colleague feedback, member checks, and a debriefing were used to guarantee the quality of the data.

Result

Eleven subthemes, including main theme of "lived with burdens of immunodeficiency virus," "disclosure," "ART adherence," and "future aspiration," were used to describe the findings. The participants discussed how difficult it has been for them to deal with social, emotional, and psychological difficulties in addition to living with the HIV infection. They kept their illness a secret from others out of fear of prejudice and stigma. In conclusion, adolescents infected with the human immunodeficiency virus faced a variety of difficulties related to their mental health, relationships, emotions, and compliance. It is advised that the community get ongoing, comprehensive health education in order to prevent stigmatization and discrimination against young people who have the virus.
Effect of proprioceptive neuromuscular facilitation on patients with chronic ankle instability: A systematic review and meta-analysis
Authors: Yin Yikun , Wang Jialin , Lin Qihan , Luo Yinghang , Liu Yongsheng , Sun Junzhi
Published: January 2025

Objective

This study conducts a rigorous meta-analysis of existing literature to rigorously examine the efficacy of Proprioceptive Neuromuscular Facilitation (PNF) in ameliorating functional deficits associated with Chronic Ankle Instability (CAI).

Methods

Literature searches were conducted in multiple databases including China National Knowledge Infrastructure (CNKI), VIP, Wanfang, China Biology Medicine disc (CBM), PubMed, EBSCO (Medline, CINAHL, SPORTDiscus, and Rehabilitation & Sports Medicine Source), Embase, ScienceDirect, ProQuest, Cochrane Library, and Web of Science for randomized controlled trials assessing the effects of Proprioceptive Neuromuscular Facilitation interventions on patients with Chronic Ankle Instability. The publication timeframe spanned from the inception of each database until April 10, 2024. Meta-analysis was performed using STATA 12 software on the included studies.

Results

① A total of 12 randomized controlled trials were included, encompassing 405 patients with Chronic Ankle Instability, demonstrating a generally high methodological quality of the literature.② Meta-analysis results indicate that compared to the control group, Proprioceptive Neuromuscular Facilitation (PNF) significantly enhanced the balance ability of patients with Chronic Ankle Instability as measured by the Y Balance Test (YBT) (Weighted Mean Difference (WMD) = 3.61, 95% CI [2.65, 4.56], z = 7.42, P<0.001) and the Star Excursion Balance Test (SEBT) (WMD = 5.50, 95% CI [3.80, 7.19], z = 6.36, P<0.001), with improvement in all eight directions of SEBT balance ability surpassing that of the control group (P<0.05); muscle strength around the ankle (SMD) = 0.19, 95% CI [0.03, 0.36], z = 2.26, P = 0.024), with both Plantar flexion and Dorsal flexion muscle strength improvements exceeding those of the control group (P<0.05); Visual Analog Scale (VAS) (WMD = -1.39, 95% CI [-1.72, -1.06], z = 8.23, P<0.001); Ankle instability questionnaire (WMD = 2.91, 95% CI [1.92, 3.89], z = 5.78, P<0.001).③Descriptive analysis results showed that the differences in Inversion Joint Position Sense and Dorsiflexion range of motion between the PNF and control groups were not statistically significant (P>0.05), however, the effects of PNF training persisted for a certain period even after cessation of treatment.

Conclusion

Proprioceptive Neuromuscular Facilitation (PNF) can significantly improve balance, muscle strength, and pain in patients with Chronic Ankle Instability (CAI). While PNF has shown improvements in joint position sense and dorsiflexion range of motion for CAI patients, with effects that remain for a period thereafter, these improvements were not significantly different when compared to the control group. Further research is required to substantiate these specific effects.
Determination of production capacity for open-pit coal mines under uncertainty: A model based on economies of scale
Authors: Wang Shuai , Cao Bo , Bai Runcai , Liu Guangwei
Published: January 2025

The determination of optimal production capacity for open-pit mines is influenced by various economic and technical factors and is highly susceptible to uncertainties. To effectively address the impact of uncertainty on capacity planning, this study develops a production capacity planning model for open-pit coal mines, based on the theory of economies of scale and incorporating multiple uncertainty constraints. A novel method is proposed to quantify and propagate the uncertainties of key capacity control factors, alongside a comprehensive uncertainty analysis framework for total revenue. Using a large-scale open-pit mine as a case study, the relationships and calculation tables for the uncertainties of key control factors are provided. Based on this, a mathematical expression for total revenue under the influence of multiple uncertainties is formulated, and the optimal capacity range is calculated. The application of the model is demonstrated through this case study, revealing that the uncertainties in production costs and coal prices are (-13.05%, +27.68%) and (-10.79%, +10.79%) respectively. Subsequently, risk-tolerant capacity planning recommendations are proposed, effectively mitigating the impact of uncertainties on production capacity determination.
Treadmill belt accelerations may not accurately replicate kinematic responses to tripping on an obstacle in older people
Authors: Jung Dayeon C. , Sturnieks Daina L. , McDonald Kirsty A. , Song Patrick Y. H. , Davis Michael K. , Lord Stephen R. , Okubo Yoshiro
Published: January 2025

Background

Treadmill belt perturbations have high clinical feasibility for use in perturbation-based training in older people, but their kinematic validity is unclear. This study examined the kinematic validity of treadmill belt accelerations as a surrogate for overground walkway trips during gait in older people.

Methods

Thirty-eight community-dwelling older people were exposed to two unilateral belt accelerations (8 m s-2) whilst walking on a split-belt treadmill and two trips induced by a 14 cm trip-board whilst walking on a walkway with condition presentation randomised. Anteroposterior margin of stability (MoS), number of falls, and trunk and lower limb kinematics were quantified for the step prior and five recovery steps following the treadmill perturbations and the walkway trips which elicited elevating and lowering strategies.

Findings

Rates of falls following the treadmill accelerations and walkway trips were 0% and 13.1%, respectively. MoS was similar during the first recovery step (P>0.05) but less negative during subsequent recovery steps following treadmill belt accelerations than walkway trips (P<0.01) regardless of recovery strategy. Excluding the first recovery step in the lowering strategy, recovery step lengths, toe clearance, maximum trunk, hip and knee angles (P<0.05) were smaller during recovery on the treadmill compared to the walkway.

Interpretation

Destabilisation by treadmill belt accelerations quickly dissipated after only one recovery step but continued for multiple recovery steps following walkway trips. Smaller trunk displacement, step lengths, toe clearance and no falls on the treadmill indicate treadmill belt accelerations may not accurately simulate the biomechanical challenge of obstacle-induced trips in older people.
Self- versus clinician-collected swabs in anal cancer screening: A clinical trial
Authors: Dyer Clare E. F. , Jin Fengyi , Roberts Jennifer M. , Poynten I. Mary , Farnsworth Annabelle , McNally Leon P. , Cunningham Philip H. , Grulich Andrew E. , Hillman Richard J.
Published: January 2025

Background

Risk of anal cancer is high in certain populations and screening involves collection of anal swabs for HPV DNA and/or cytology testing. However, barriers exist, such as the need for an intimate examination, and stigma around HIV status, sexual orientation, and sexual practices. Self-collected anal swabs (SCA) are a proposed alternative to clinician-collected swabs (CCA) to overcome these barriers.

Methods

Participants were order-randomised to undergo SCA or CCA first, with a second swab taken immediately afterwards. Sample adequacy was assessed for HPV DNA and cytology testing. CCA was used as the gold standard to calculate sensitivity and specificity of SCA for cytology and HPV results. Acceptability of swab collection was assessed following the procedure.

Results

There was no significant difference in sample validity for HPV DNA testing between SCA and CCA (p = 0.564). Concordance was >90% for detection of any HR-HPV and HPV16. There was no significant difference in cellular adequacy for cytological testing between SCA and CCA, (p = 0.162). Concordance for cytologic prediction was 88.2% for any cytologic abnormality. Almost half (48.5%) of participants expressed no preference for SCA versus CCA; 15.2% preferred SCA and 35.4% CCA.

Conclusions

SCA may be an acceptable and feasible alternative to CCA for detecting HPV and cytological abnormalities in a clinic population.
Next-generation sequencing protocol of hematopoietic stem cells (HSCs). Step-by-step overview and troubleshooting guide
Authors: Jarczak Justyna , Bujko Kamila , Brzeźniakiewicz-Janus Katarzyna , Ratajczak Mariusz , Kucia Magdalena
Published: January 2025

Populations of very small embryonic-like stem cells (VSELs) (CD34+lin-CD45- and CD133+lin-CD45-), circulating in the peripheral blood of adults in small numbers, have been identified in several human tissues and together with the populations of hematopoietic stem cells (HSCs) (CD34+lin-CD45+) and CD133+lin-CD45+constitute a pool of cells with self-renewal and pluripotent stem cell characteristics. Using advanced cell staining and sorting strategies, we isolated populations of VSELs and HSCs for bulk RNA-Seq analysis to compare the transcriptomic profiles of both cell populations. Libraries were prepared from an extremely small number of cells; however, their good quality was preserved, and they met the criteria for sequencing. We present here a step-by-step NGS protocol for sequencing VSELs and HSC with a description of troubleshooting during library preparation and sequencing.
Reproducibility and repeatability of 18F-(2S, 4R)-4-fluoroglutamine PET imaging in preclinical oncology models
Authors: Ayers Gregory D. , Cohen Allison S. , Bae Seong-Woo , Wen Xiaoxia , Pollard Alyssa , Sharma Shilpa , Claus Trey , Payne Adria , Geng Ling , Zhao Ping , Tantawy Mohammed Noor , Gammon Seth T. , Manning H. Charles
Published: January 2025

Introduction

Measurement of repeatability and reproducibility (R&R) is necessary to realize the full potential of positron emission tomography (PET). Several studies have evaluated the reproducibility of PET using 18F-FDG, the most common PET tracer used in oncology, but similar studies using other PET tracers are scarce. Even fewer assess agreement and R&R with statistical methods designed explicitly for the task. 18F-(2S, 4R)-4-fluoro-glutamine (18F-Gln) is a PET tracer designed for imaging glutamine uptake and metabolism. This study illustrates high reproducibility and repeatability with 18F-Gln for in vivo research.

Methods

Twenty mice bearing colorectal cancer cell line xenografts were injected with ~9 MBq of 18F-Gln and imaged in an Inveon microPET. Three individuals analyzed the tumor uptake of 18F-Gln using the same set of images, the same image analysis software, and the same analysis method. Scans were randomly re-ordered for a second repeatability measurement 6 months later. Statistical analyses were performed using the methods of Bland and Altman (B&A), Gauge Reproducibility and Repeatability (Gauge R&R), and Lin’s Concordance Correlation Coefficient. A comprehensive equivalency test, designed to reject a null hypothesis of non-equivalence, was also conducted.

Results

In a two-way random effects Gauge R&R model, variance among mice and their measurement variance were 0.5717 and 0.024. Reproducibility and repeatability accounted for 31% and 69% of the total measurement error, respectively. B&A repeatability coefficients for analysts 1, 2, and 3 were 0.16, 0.35, and 0.49. One-half B&A agreement limits between analysts 1 and 2, 1 and 3, and 2 and 3 were 0.27, 0.47, and 0.47, respectively. The mean square deviation and total deviation index were lowest for analysts 1 and 2, while coverage probabilities and coefficients of the individual agreement were highest. Finally, the definitive agreement inference hypothesis test for equivalency demonstrated that all three confidence intervals for the average difference of means from repeated measures lie within our a priori limits of equivalence (i.e. ± 0.5%ID/g).

Conclusions

Our data indicate high individual analyst and laboratory-level reproducibility and repeatability. The assessment of R&R using the appropriate methods is critical and should be adopted by the broader imaging community.
Knockout of the ING5 epigenetic regulator confirms roles in stem cell maintenance and tumor suppression in vivo
Authors: Al Shueili Buthaina , Dantas Arthur , Mahe Etienne , Chu Tak Ho , Yang Yang , Labit Elodie , Kutluberk Eren , Lasaleta Nicolas , Masson Anand , Omairi Hiba , Ito Kenichi , Krawetz Roman J. , Midha Rajiv , Cairncross Gregory , Riabowol Karl
Published: January 2025

INhibitor of Growth (ING1-5) proteins are epigenetic readers that target histone acetyltransferase (HAT) or histone deacetylase (HDAC) complexes to the H3K4Me3 mark of active transcription. ING5 targets Moz/Morf and HBO1 HAT complexes that alter acetylation of H3 and H4 core histones, affecting gene expression. Previous experiments in vitro indicated that ING5 functions to maintain stem cell character in normal and in cancer stem cells. Here we find that CRISPR/Cas9 ING5 knockout (KO) mice are sub-fertile but show no decrease in lifespan or ability to heal wounds despite indications of depleted stem cell pools in several tissues. ING5 KO mouse embryo fibroblasts accumulate in G2 of the cell cycle, have high levels of abnormal nuclei and show high basal levels of the γH2AX indicator of DNA damage. KO animals also develop severe dermatitis at a 5-fold higher rate that wild-type littermates. Consistent with ING5 serving a tumor suppressive role, ING5 KO mice developed germinal centre diffuse large B-cell lymphomas at a rate 6-fold higher than control mice at 18 months of age. These data suggest that ING5 functions in vivo to maintain stem cell character in multiple organs, that reduction of stem cell populations is not limiting for murine lifespan and that like a subset of other ING family members, ING5 functions as a tumor suppressor in hematopoietic cells in vivo.
Disability and pain after lumbar surgery–group-based trajectory analysis
Authors: Koivunen Konsta , Arokoski Jari , Widbom-Kolhanen Sara , Pernaa Katri , Juhola Juhani , Saltychev Mikhail
Published: January 2025

Background and aims

Previous studies in lumbar spine surgery have mainly studied functioning and pain by comparing average scores from Patient Reported Outcome Measures (PROMs) at different time points. Less is known about these changes in different subgroups. It is self-evident that, while most patients may demonstrate trajectories of these changes close to the average one, some groups may follow more or less different trends. Also, it is unclear which preoperative factors may affect the probability of being classified into groups with different development trajectories of surgical outcome. The objective of this study was to identify groups exhibiting distinct trajectories within the broader cohort of patients undergoing lumbar spine surgery and to determine whether certain factors may be associated with a probability of being classified into a particular group.

Methods

This was a register-based study of 1,451 patients undergoing lumbar spine surgery. The group-based trajectory analysis was used separately for leg pain, for back pain, and for functioning. The probability of group membership was calculated based on sex, age, leg and back pain duration before surgery, and obesity.

Results

Two kinds of group-based trajectories were identified for each of three-factor variables: a long-term and a short-term improvement group. Sex and age were not associated with being classified into short-term improvement groups, but obesity was associated for all three-factor variables with relative risk ratios (RRR) varying from 1.26 (95% CI 1.02 to 1.56) to 1.45 (95% CI 1.10 to 1.90). Preoperative leg and back pain duration was significantly associated solely with back pain severity with an RRR of 1.28 (95% CI 1.01 to 1.61).

Conclusions

The results of this study suggest that most of the patients may experience pain relief and improved functioning within three months after lumbar surgery, and this effect may last, at least, for two years. Higher BMI and worse preoperative pain and disability were associated with the inferior outcome of surgery. When considering surgery, planning pre- and postoperative rehabilitation, or forecasting the use of pain medications, a higher probability of worse outcome could be expected for overweight and initially more painful patients with higher level of disability.
Comprehensive multi-metric analysis of user experience and performance in adaptive and non-adaptive lower-limb exoskeletons
Authors: Supapitanon Krongkaew , Patathong Tanyaporn , Akkawutvanich Chaicharn , Srisuchinnawong Arthicha , Ketrungsri Worachit , Manoonpong Poramate , Woratanarat Patarawan , Angsanuntsukh Chanika
Published: January 2025

Among control methods for robotic exoskeletons, biologically inspired control based on central pattern generators (CPGs) offer a promising approach to generate natural and robust walking patterns. Compared to other approaches, like model-based and machine learning-based control, the biologically inspired control provides robustness to perturbations, requires less computational power, and does not need system models or large learning datasets. While it has shown effectiveness, a comprehensive evaluation of its user experience is lacking. Thus, this study addressed this gap by investigating the performance of a state-of-the-art adaptive CPG-based exoskeleton control system (intelligent mode) under a multi-metric analysis (involving three-dimensional gait analysis, muscle activity, oxygen consumption, user comfort, and exoskeleton performance scores) and comparing it to a standard commercial exoskeleton control system (default mode). A cross-over design with randomized allocation in Thai healthy and independently walking adults ensured participants experienced both modes. All participants were assigned into two groups to receive an alternate sequence of walking with the intelligent mode or the default mode of the lower-limb exoskeleton Exo-H3 at high and normal speed. From eight participants, the intelligent mode-driven exoskeleton (adaptive exoskeleton) showed a significantly lower velocity, stride, and step lengths than the default mode-driven exoskeleton (non-adaptive exoskeleton). This setup significantly increased anterior pelvic tilt during mid-swing at normal speed (3.69 ± 1.77 degrees, p = 0.001) and high speed (2.52 ± 1.69 degrees, p = 0.004), hip flexion during stance phase with ankle dorsiflexion, and used less oxygen consumption at high speed (-2.03 ± 2.07 ml/kg/min) when compared to the default one. No significant differences of muscle activity, user comfort and exoskeleton performance scores between the two modes. Further exoskeletal modification in terms of hardware and control is still needed to improve the temporal spatial, kinematics, user comfort, and exoskeleton performance.
Patient safety indicators for virtual consultations in primary care: A systematic review protocol
Authors: Lunova Tetiana , Kirk Ulrik Bak , Greenfield Geva , Rochfort Andrée , Darzi Ara , Neves Ana Luisa
Published: January 2025

Background

Virtual consultations are being increasingly incorporated into routine primary care, as they offer better time and geographical flexibility for patients while also being cost-effective for both patients and service providers. At the same time, concerns have been raised about the extent to which virtual care is safe for patients. As of now, there is no validated methodology for evaluating the safety nuances and implications of virtual care. This study aims to identify patient safety indicators that could be used to evaluate the safety of virtual consultations in primary care.

Methods

A literature search will be performed in Ovid MEDLINE/PubMed, Embase, and Cochrane Library for relevant articles published over the last 10 years (2014–2024). The systematic review will include randomized and non-randomized controlled trials and observational studies with adult populations that compare synchronous patient-provider virtual consultations (telephone or video) or multicomponent interventions involving synchronous remote consultations with face-to-face consultations. The outcome of interest will be patient safety indicators extracted from the studies. The quality of randomized controlled trials will be assessed with the Cochrane Risk of Bias Tool, and the Newcastle-Ottawa Scale will be used to analyze risk of bias in observational studies.

Discussion

Considering the growing adoption of virtual medical care worldwide, a robust and comprehensive evaluation of its safety and quality is now a system-wide priority. Therefore, one of the primary strengths of this proposed systematic review is its focus on a topic of great importance and timeliness, specifically addressing the existing knowledge gap in this area. By publishing this protocol, we demonstrate the transparency and reliability of our research strategy and aim to minimize the risk of selection bias. Potential limitations include the heterogeneity of measures and outcomes, as well as a lower-than-expected number of studies in subgroup analyses, which may negatively influence the statistical significance in data synthesis.

Trial registration

PROSPERO registration number: CRD42023464878.
Widespread use of ChatGPT and other Artificial Intelligence tools among medical students in Uganda: A cross-sectional study
Authors: Ajalo Elizabeth , Mukunya David , Nantale Ritah , Kayemba Frank , Pangholi Kennedy , Babuya Jonathan , Langoya Akuu Suzan , Namiiro Amelia Margaret , Nsubuga Yakobo Baddokwaya , Mpagi Joseph Luwaga , Musaba Milton W. , Oguttu Faith , Kuteesa Job , Mubuuke Aloysius Gonzaga , Munabi Ian Guyton , Kiguli Sarah
Published: January 2025

Background

Chat Generative Pre-trained Transformer (ChatGPT) is a 175-billion-parameter natural language processing model that uses deep learning algorithms trained on vast amounts of data to generate human-like texts such as essays. Consequently, it has introduced new challenges and threats to medical education. We assessed the use of ChatGPT and other AI tools among medical students in Uganda.

Methods

We conducted a descriptive cross-sectional study among medical students at four public universities in Uganda from 1st November 2023 to 20th December 2023. Participants were recruited by stratified random sampling. We used a semi-structured questionnaire to collect data on participants’ socio-demographics and use of AI tools such as ChatGPT. Our outcome variable was use of AI tools. Data were analyzed descriptively in Stata version 17.0. We conducted a modified Poisson regression to explore the association between use of AI tools and various exposures.

Results

A total of 564 students participated. Almost all (93%) had heard about AI tools and more than two-thirds (75.7%) had ever used AI tools. Regarding the AI tools used, majority (72.2%) had ever used ChatGPT, followed by SnapChat AI (14.9%), Bing AI (11.5%), and Bard AI (6.9%). Most students use AI tools to complete assignments (55.5%), preparing for tutorials (39.9%), preparing for exams (34.8%) and research writing (24.8%). Students also reported the use of AI tools for nonacademic purposes including emotional support, recreation, and spiritual growth. Older students were 31% less likely to use AI tools compared to younger ones (Adjusted Prevalence Ratio (aPR):0.69; 95% CI: [0.62, 0.76]). Students at Makerere University were 66% more likely to use AI tools compared to students in Gulu University (aPR:1.66; 95% CI:[1.64, 1.69]).

Conclusion

The use of ChatGPT and other AI tools was widespread among medical students in Uganda. AI tools were used for both academic and non-academic purposes. Younger students were more likely to use AI tools compared to older students. There is a need to promote AI literacy in institutions to empower older students with essential skills for the digital age. Further, educators should assume students are using AI and adjust their way of teaching and setting exams to suit this new reality. Our research adds further evidence to existing voices calling for regulatory frameworks for AI in medical education.
Evaluation and adaptation of a two-way text messaging intervention in the WIC breastfeeding peer counseling program: A qualitative analysis
Authors: Martinez-Brockman Josefa L. , Granner Josephine R. , Buchanan Brice , Acosta Lisbette , Lonczak Marilyn , Goeschel Lori , Xu Xiao , Curry Leslie , Nunez-Smith Marcella , Pérez-Escamilla Rafael
Published: January 2025

Breastfeeding (BF) is vital for maternal and infant health, yet post-hospital discharge support remains a challenge. The Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) provides BF peer counseling prenatally and up to 1-year postpartum among low-income women in the United States. The Lactation Advice Through Texting Can Help (LATCH) intervention is an evidence-based two-way text messaging intervention that provides BF education and support in the WIC peer counseling program. The intervention is implemented by peer counselors (PCs) in the WIC program, with the supervision and support of a lactation consultant. The aim of this qualitative study was to assess the barriers and facilitators to the implementation of LATCH during the feasibility trial and to investigate strategies for adapting and scaling up the intervention. In-depth interviews with LATCH and PC program key informants aimed to evaluate the intervention and explore its adaptation and scale-up. Interviews were analyzed using line by line inductive thematic analysis. Findings were mapped to the Model for Adaptation Design and Impact (MADI) framework to describe the proposed adaptations, and to the Program Impact Pathways (PIP) framework to identify causal pathways and critical quality control points. Results demonstrate that LATCH facilitates continued engagement between PCs and WIC mothers; however, implementation feasibility issues remain. Suggested adaptations to LATCH include the use of an integrated comprehensive platform, ensuring continuity of care through an expanded spectrum of communication options, the need to develop a PC support model for “off hours” (non-business hours), and the need to obtain local WIC office management’s buy-in for the communications platform and the off-hours PC model. Critical quality control points were identified when results were mapped to the MADI and PIP frameworks. Implementing these changes has the potential to expand access to BF peer counseling support and improve BF equity among low-income women.
Behaviors and influencing factors of Chinese oncology nurses towards frailty care: A cross-sectional study based on knowledge-attitude-practice theory in 2024
Authors: Chen Xiaoxue , Xiao Fang , Miao Yuhua , Qin Huiying , Yang Lirong , Shen Fang , Yuan Xiuhong
Published: January 2025

Background

The demand for frailty care is continuously increasing in hospitalized tumor patients with the aging of the population. Nurses are the primary care providers of hospitalized tumor patients with frailty but research on exploring their behavior and associated factors is limited. This study aims to describe the current situation of frailty care behaviors in oncology nurses and to explore the factors influencing frailty care behaviors.

Methods

From August 1, 2023, to March 31, 2024, this cross-sectional study was conducted among nurses from oncology-related departments in 5 Secondary A (mid-tier hospitals providing comprehensive care) or above hospitals in South China. Convenience sampling was employed to recruit participants. In China, a "Secondary A hospital is a mid-tier hospital that provides comprehensive medical care and handles more complex cases than primary hospitals but is smaller and less specialized than tertiary hospitals. Data were collected using the standardized frailty-knowledge, attitudes, and practices questionnaire (F-KAP) and general information questionnaire including sociodemographic and work-related details. The sub-scale scores of knowledge, attitude, and practice were calculated by summing up the items within each sub-scale. Student’s independent t-test, one-way ANOVA, Pearson’s correlation coefficient, and two kinds of multiple linear regression models were used for data analysis.

Results

We included a total of 17 (3.70%) male and 443 (96.30%) female participants in this study. The mean total score of oncology nurses for frailty care behaviors was 33.26±6.61. The three lowest scoring behaviors were “conduct frailty measurements and screening for patients (3.30±1.12)”, “accumulate frailty-related knowledge in daily work (3.59±0.87)”, and “actively pay attention to the patient’s debilitating condition”. Pearson’s correlations analysis showed that nursing grades (r = 0.13), frailty-related training willingness (r = 0.18), nursing frail patients experience (r = 0.22), frailty-related knowledge learning experience (r = 0.33), frailty-related training experience (r = 0.17), frailty care knowledge (r = 0.23), and hospice care attitudes (r = 0.54) were positively associated with frailty care behaviors. Two kinds of multiple linear regression models both showed that the factors most significantly associated with the oncology nurses’ frailty care behaviors are their self-rated subjective knowledge and attitudes towards frailty identification.

Conclusion

Oncology nurses practiced relatively low-frequency frailty in daily work. Our findings provide theoretical support for improving frailty care attitudes among nurses and enhancing patient quality of life.
Hemoglobin, albumin, lymphocyte and platelet (HALP) score for predicting early and late mortality in elderly patients with proximal femur fractures
Authors: Vural Abdussamed , Dolanbay Turgut , Yagar Hilal
Published: January 2025

Background

Predicting mortality and morbidity poses a significant challenge to physicians, leading to the development of various scoring systems. Among these, the hemoglobin, albumin, lymphocyte and platelet (HALP) score evaluates a patient’s nutritional and immune status. The primary aim of this study was to determine the predictive effect of the HALP score on 30-day and 1-year mortality in elderly patients with proximal femoral fractures (PFFs).

Materials and methods

Patient demographic, clinical, laboratory, and prognostic data were obtained. The patients were categorized into two groups: survival and nonsurvival at mortality endpoints. The HALP score was calculated and compared among the groups and with other mortality biomarkers such as C-reactive protein (CRP) and C-reactive protein to albumin ratio (CAR). The ability of the HALP score to predict mortality was compared between the groups. The mortality risk was also calculated at the optimal threshold.

Results

The HALP score had a statistically significant predictive effect on mortality endpoints and was lower in the non-surviving group. The ability of the HALP score to predict 1-year mortality at the optimal cut-off value (17.975) was superb, with a sensitivity of 0.66 and specificity of 0.86 (AUC: 0.826, 95% CI: 0.784–0.868). In addition, the power of the HALP score to differentiate survivors and non-survivors was more significant than that of other indices (p < 0.001). Patients with a HALP score ≤ 17.975 had a 1-year mortality risk 11.794 times that of patients with a HALP score ≥ 17.975 (Odds ratio: 11.794, 95% CI [7.194–19.338], p < 0.001).

Conclusion

The results indicate that the HALP score demonstrates efficacy and utility in predicting 30-day and 1-year mortality risk among elderly patients with PFFs.
Like milk on the stove: Healthcare professionals navigating uncertainty when caring for families with 22q11DS
Authors: Ayoub Sophie , De Clercq Eva , Cytrynbaum Cheryl , Steiner Luzius A. , Elger Bernice S.
Published: January 2025

Introduction

22q11 deletion syndrome (22q11DS) results from a microdeletion on chromosome 22 and is the most common microdeletion disorder in humans, affecting 1 in 2148 live births. Clinical manifestations vary widely among individuals and across different life stages. Effective management requires the involvement of a specialized multidisciplinary team. This study aims to explore the experiences of healthcare professionals in caring for the families of children with 22q11DS, focusing on their challenges, rewards, and coping strategies.

Methods

Data for this interview study were collected as part of a broader mixed methods research project aimed at enhancing the psychosocial well-being of children aged 3–15 years with 22q11DS and their families. The qualitative aspect of this study focused on capturing the experiences of healthcare professionals involved in their care, recruited purposively through collaborators and snowball sampling methods. Reflexive thematic analysis of semi-structured interviews was performed after verbatim transcription.

Results

Twenty healthcare providers from different specialties were interviewed. The majority had a working experience of more than 10 years and were part of a 22q11DS clinic. After data analysis, four themes (and many sub-themes) were identified that were all related to the topic of uncertainty: acknowledging uncertainty, sharing uncertainty, acting on uncertainty and coping with uncertainty. Many experts showed a sense of humbleness when caring for the families and most of the participants emphasized the role of peer support and multidisciplinary teams.

Conclusion

Our study reveals how healthcare professionals manage the uncertainty associated with 22q11DS, highlighting the importance of peer support and multidisciplinary team collaboration. Providers recognize the limits of their medical expertise and value the perspectives of families living with the condition. Their coping strategies play a critical role in handling uncertainty and suggest a need for further emphasis in the literature on the experiences of healthcare professionals dealing with rare diseases.
Diaper dermatitis and associated factors among children aged 0–24 months in low- and middle-income countries: A systematic review protocol
Authors: Negera Atoma , Sento Midekso , Dereje Debela , Firdisa Gamachis , Negera Samuel , Nenko Geleta , Sime Tadesse , Keba Merga
Published: January 2025

Background

Diaper dermatitis (DD, sometimes known as diaper rash or napkin dermatitis is one of the most prevalent skin infections that occur in the area covered by the diaper. Although diaper dermatitis can be seen in any patient wearing diapers, it is reported to be more common in infants aged 9–12 months. Approximately, 70% of infants and young children suffer from diaper dermatitis at some point during their diaper wearing years and up to 25% of children seek healthcare due to this case.

Methods and analysis: Methods and analysis

A comprehensive literature search will be gathered from electronic databases such as PubMed, Embase, Hinari, Cochrane Library, African Journals Online (AJOL), and Google Scholar. The protocol followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses for Protocol (PRISMA-P) guideline. All studies conducted in low- and middle-income countries (LMICs) will be included regardless of their study design as long as these studies report the magnitude of the problem under study. Joanna Briggs Institute’s (JBI) appraisal checklist will be used to assess the quality of individual studies. Heterogeneity will be checked using Cochrane Q test statistics and I2 test statistics, and a random-effects model will be employed to estimate the pooled prevalence of DD and its associated factors.

Ethics and dissemination of research

Ethics committee approval or written informed consent will not be required to conduct this review, and meta-analysis for the review will be entirely based on published data. The result of this study will be submitted to a peer-reviewed journal, and it will also be presented at relevant research conferences.

Results

The present study will estimate the pooled prevalence of diaper dermatitis and their associated factors in low- and middle-income countries.

Trial registration

PROSPERO registration number: CRD42024578550.
Digital technology innovation, supply chain resilience and enterprise performance-The case of listed automotive parts manufacturing companies
Authors: Chen Xiangbing , Sun Chen , Wang Fang
Published: January 2025

Digital technology innovation (DTI) is the core driving force for the development of the digital economy. This paper brings digital technology innovation and the supply chain of auto parts manufacturing under the same framework. This paper uses Stata 18 to empirically analyze the panel data of 130 A-share auto parts listed companies in Shanghai and Shenzhen from 2010 to 2022. The digital technology innovation indicator is divided into three levels: substantial digital technology innovation (SDTI), non-substantial digital technology innovation (NDTI), overall digital technology innovation (ODTI). To explore its impact mechanism on enterprise performance. The empirical results show that: (1) Digital technological innovation (DTI) has a positive and significant impact on enterprise performance, and supply chain resilience plays a mediating role in the relationship between digital technology innovation and enterprise performance, and R&D investment (RDI) positively moderates the role of supply chain resilience in promoting enterprise performance. (2) Heterogeneity analysis showed that the impact of supply chain resilience on enterprise performance was more significant in small and medium-sized enterprises. There are significant differences between different groups of business ownership. In economically underdeveloped regions, the effect of digital technology innovation on enterprise performance is more significant. This paper complements the perspective of supply chain to study the relationship between digital technology innovation and enterprise performance, expands the existing research, and its heterogeneity analysis provides new insights for understanding China’s auto parts manufacturing industry. This provides a basis for strengthening digital technology innovation and promoting the sustainable development of the auto parts industry.
The role of the microbiota and metabolites in the treatment of pulmonary fibrosis with UC-MSCs: Integrating fecal metabolomics and 16S rDNA analysis
Authors: Luo Yukai , Zhou Shuang , Zhang Xiaojing , Lin Yijian , Liu Jun , Cheng Wenzhao , Zeng Yiming
Published: January 2025

Introduction

Pulmonary fibrosis (PF) is a chronic and irreversible interstitial lung disease characterized by a lack of effective therapies. Mesenchymal stem cells (MSCs) have garnered significant interest in the realm of lung regeneration due to their abundant availability, ease of isolation, and capacity for expansion. The objective of our study was to investigate the potential therapeutic role of umbilical cord-derived MSCs (UC-MSCs) in the management of PF, with a focus on the alterations in the gut microbiota and its metabolites during the use of UC-MSCs for the treatment of pulmonary fibrosis, as well as the possible mechanisms involved.

Methods

Bleomycin injection was utilized to establish a mouse model of lung fibrosis, followed by the application of 16S rDNA sequencing and LC–MS/MS metabolomics to explore the underlying mechanism of UC-MSC treatment for lung fibrosis. Seventy-five mice were allocated into five groups, namely Control, Model, and low/medium/high dose of UC-MSCs groups, and survival metrics, lung morphology, and the levels of the inflammatory cytokines TNF-α, IL-1β, IL-6, and TGF-β1 were subsequently evaluated. Fecal samples from six mice in each of the Control group, Model group, and UC-MSCs-M groups were collected randomly for 16S rDNA sequencing to analyze the gut microbiota and nontargeted metabolomics.

Results

In comparison to IPF model mice, the three treatment groups exhibited increased survival rates, restored alveolar morphology, and reduced levels of the inflammatory cytokines TNF-α, IL-1β, IL-6, and TGF-β1, confirming the anti-inflammatory properties of UC-MSCs in IPF treatment. The findings from the 16S rDNA assay indicate that UC-MSCs treatment effectively lower α-diversity induced such as Chao 1 and ACE, as well as β-diversity, leading to a decrease in microbiota abundance. The findings from the metabolomics analysis revealed that the metabolites exhibiting notable variances were primarily composed of Lipids and lipid-like molecules, Organoheterocyclic compounds, Organic acids and derivatives, and Benzenoids, indicating the potential of UC-MSCs to exert antifibrotic effects via these metabolic pathways.

Conclusion

Umbilical cord-derived mesenchymal stem cells (UC-MSCs) ameliorate bleomycin-induced pulmonary fibrosis symptoms in mice by exerting anti-inflammatory effects and mitigating pulmonary fibrosis through the modulation of gut microbiota disorders and their metabolism. These findings offer novel insights into the potential mechanisms and clinical utility of stem cell therapy for pulmonary fibrosis.
The association of financial resources and loneliness among older adults during a state of emergency
Authors: Drost Madeleine , Loibl Cäzilia , Snyder Anastasia , Betz Michael
Published: January 2025

This study focuses on the initial wave of the COVID-19 pandemic in Spring 2020 in the United States to assess how liquidity constraints were related to loneliness among older adults. Data are from the COVID Impact Survey, which was used to collect data in April, May and June 2020 across the U.S. (n = 5,664). We use means comparison tests and linear regressions and find that emergency savings, rather than household income, predict loneliness among older adults during the initial COVID-19 wave. Emergency savings, especially enough to avoid using credit cards, was most predictive of older adult loneliness levels. Income and access to emergency savings did not influence the relationship between actions taken and personal plans changed as a result of COVID-19. Easing lockdown restrictions was unrelated to the relationship between loneliness and liquidity constraints, actions taken and personal plans changed due to the COVID-19 pandemic. Findings suggest that, in the early months of the COVID-19 pandemic, loneliness associated with the actions taken to avoid COVID-19 and personal plans changed was experienced across all socio-economic groups of older adults in this sample in similar ways, regardless of income levels and wealth. In addition, a better understanding of loneliness in older age during the COVID-19 pandemic may require a fuller analysis of households’ financial situation beyond income, and points to the central role of credit card debt for loneliness in older age.
Interrogating green social prescribing in South Wales; A multi-stakeholder qualitative exploration
Authors: Brown Menna , Aylett Katharine Sarah
Published: January 2025

Background

As an umbrella term, social prescribing offers varied routes into society which promise to support, enhance, and empower individual citizens to take control of their own health and wellbeing. Globally healthcare systems are struggling to cope with the increasing demands of an ageing population and the NHS (UK) is no exception. Social prescribing is heralded as a means to relieve the burden on primary care and provide support for the 20% of patients whose needs are non-medical. As such an increasing array of schemes are available, spanning five sub-sets: creative or nature-based referrals, welfare services, exercise referrals, education programmes or befriending support. Green social prescription offers significant potential to promote wellbeing and improve health outcomes. However limited research has explored this emergent sub-set.

Aim

Explore and interrogate the concept of social prescribing to understand how it is conceptualised, perceived, and experienced by different stakeholders involved in its coordination, delivery, and provision; At a time when it is being formalised in Wales, UK.

Methods

Using qualitative enquiry, from a social constructivist paradigm, stakeholder perspectives pertaining to current social prescribing models, pathways and actions in Wales were explored. Three multi-discipline research workshops and ten semi-structured, one-to-one interviews were conducted either in person or via zoom. Qualitative data were analysed thematically.

Results

39 different stakeholders contributed. These included social prescribers, community connectors, service coordinators, third sector and voluntary organisation representatives, a general practitioner, occupational therapist, social enterprisers, academics and local area coordinators. Five themes were identified which revolved around stakeholders discussions of critical challenges pertaining to the delivery, provision, and evaluation of green social prescribing schemes in south Wales, UK. Tension between varying stakeholders was also evident, often preceded, or complicated by funding discrepancies, competition, and uncertainty. Stakeholders demanded clarity regarding evaluation outcomes and benchmarking across the sector.

Conclusions

To ensure the continued provision of social prescribing schemes which are highly valued by service users, voluntary and third sector organisations require funding security and stability. The delivery of green, nature-based, schemes require maintenance of trusting, long-term relationships with local service co-ordinators and referrers, secure equitable funding models and agreement over conceptual basis of social prescribing itself, particularly in relation to ‘where’ social prescribing is located within health and social care models. Without resolution and positive progress across these areas the continuation of local green schemes within local communities, which build resilience and support positive change for service users’ health and wellbeing, is questionable.