bluuebunny/crossref_metadata_2025 huggingface dataset:
Estágios EAD: possibilidades em uma instituição de ensino superior
Authors: Cancian Wainer , Coelho Katia , Stringhetta Maria do Carmo Teles F , Fragal Iara
Published: December 2023

O estágio é concebido hoje para as Instituições de Ensino Superior (IES) como fonte pungente que busca trazer à tona o alinhamento entre a teoria e a prática, quer seja por meio do estágio obrigatório, quer seja por meio do estágio não-obrigatório. Neste sentido, o presente estudo busca investigar o modelo de trabalho adotado pelo setor de Estágios EAD de uma IES localizada no norte do Paraná, para atendimento de alunos e alunas quanto aos processos de estágios. O lócus central da pesquisa está no que diz respeito ao atendimento e cumprimento da Lei de Estágios (11.788 de 25 de setembro de 2008) considerando a escalabilidade, volume de atendimentos para todos os alunos, assim como documentação e campo de estágio. A problemática se deu, principalmente, por conta da estruturação de um setor para o atendimento dos alunos de estágio obrigatório e não-obrigatório. A organização dos processos do setor, embora em andamento, já evidencia resultados satisfatórios, o que contribui com este estudo de caso e adequação de um setor em constante aperfeiçoamento.
O Impacto da Política Nacional de Educação Digital no Sistema de Ensino Naval
Authors: Biagiotti Luiz Claudio Medeiros
Published: December 2023

Este artigo apresenta a Política Nacional de Educação Digital e analisa detalhadamente o seu conteúdo, comparando-o com as práticas que já vem sendo adotadas nas Organizações Militares do Sistema de Ensino Naval. Esta comparação foi bastante significativa pois possibilitou verificar que as ações que estão sendo adotadas estão alinhadas com a Lei.
A Percepção da Troca do Ensino Presencial para o Remoto em Diferentes Faixas Etárias: impacto percebido pelos estudantes, pais e professores
Authors: Santos Aguinaldo Ferreira dos , Coelho Tavany , Kai Flavia , Sales Vanessa Araujo , Claudino Rafaela Franco
Published: December 2023

Na pandemia do Sars-Cov-19 a mudança foi muito abrupta e perceptível para todos os envolvidos no processo de ensino e aprendizagem. Procura-se evidenciar o impacto percebido pelos vários atores do processo de ensino aprendizagem na mudança do ensino presencial para o ensino remoto. Usou-se entrevista com perguntas abertas e diretas a um grupo de indivíduos selecionados de acordo com sua participação nesse processo. Como resultados principais se observaram mudanças drásticas em relação a rotina do envolvido diretamente e dos seus familiares de forma indireta. Como considerações finais, esse estudo trouxe à tona a discussão sobre as mudanças na educação.
Proposta de Educação Híbrida na Formação Acadêmica e Qualificação Profissional para Atuar com Saúde Digital
Authors: Graziosi Maria Elisabete Salvador , Nascimento Débora Dupas Gonçalves do , Santos Adriana , Passos Maria Fabiana , Campos Francisco Eduardo de
Published: December 2023

Experiências de aprendizagem personalizadas, próprias da Educação a Distância e, particularmente, do ensino híbrido, são essenciais na formação e qualificação para atuar na era da Saúde Digital. Esse estudo propõe criação de abordagens educacionais híbridas que ofereçam oportunidades diversificadas na preparação de indivíduos. As seguintes etapas metodológicas subsidiaram essa construção: Revisão de Literatura, análises das evidências científicas e formulação de proposta do modelo educacional híbrido. A literatura apoiou proposta de seis módulos, considerando-se critérios pedagógicos e evidenciou a integração interdisciplinar no treinamento de habilidades como abordagem mais adequada para atuar com soluções digitais de saúde no cenário em constante evolução.
Realidade Virtual e Aumentada: uma experiência de formação de professores da rede municipal de ensino do Recife
Authors: Aleixo Adriana , Ferreira Andrea de Souza , Gomes Josefa Valéria Ferreira , Cabral Inês Vicente , Alcoforado Christine
Published: December 2023

Este relato apresenta uma experiência envolvendo uma oficina de formação para professores da educação básica, da rede municipal do Recife, em uma Unidade de Tecnologia Educativa e Cidadania (UTEC) sobre Realidade Virtual (RV) e Aumentada (RA). A experiência, objetivou subsidiar a prática docente, a partir dos recursos das Tecnologias Digitais da Informação e Comunicação, especificamente, da RV e RA, como instrumentos inovadores, condizentes com as demandas de um mundo moderno e tecnológico. Com base nos relatos dos participantes, durante a oficina, conclui-se que a formação docente possibilitou experiências significativas que podem contribuir para mudanças no processo de ensino e aprendizagem.
Estágio Supervisionado nos Cursos de Licenciatura EAD: um relato de experiência
Authors: Kraemer Daniela Regina , Horn Cláudia Inês
Published: December 2023

O estágio supervisionado, dentro de nossa instituição, é organizado no currículo acadêmico como um momento de transição e fortalecimento entre teoria e prática docente. Esse relato apresenta a metodologia e a forma como assumimos a formação de professores no contexto dos cursos de licenciatura e como os estágios acontecem na modalidade Educação a Distância (EAD).
Validação Pedagógica de Conteúdos para EAD: uma visão do designer instrucional
Authors: Costa Larissa , Viana Katia , Gomes Samira , Santos Donny Wallesson dos , Mesquita Mizraim , Oliveira Ana Oliveira , Garcia Paola Trindade
Published: December 2023

A validação pedagógica desempenha papel essencial na elaboração de recursos educacionais para a Educação à Distância, englobando diversos aspectos, como a coerência com os objetivos educacionais, o diálogo com o aluno e outros elementos pertinentes. Nesta etapa, o designer instrucional analisa o texto didático e realiza adaptações para garantir que os recursos educacionais estimulem a autonomia do aluno, além do desenvolvimento de habilidades e competências. No entanto, é importante ressaltar que essa atividade pode ser desafiadora para o designer instrucional, exigindo amplo conhecimento sobre diversos aspectos didáticos.
Dinamizando a Sala de Aula no Contexto da Cibercultura: experiência com a construção de artefatos tecnológicos nos anos iniciais do ensino fundamental
Authors: Matias Lorena de Andrade , Ferreira Graça Regina
Published: December 2023

Na atualidade, com a ressignificação da cultura digital, o ambiente escolar precisa repensar práticas pedagógicas que abarquem os artefatos interativos presentes no cotidiano dos educandos. Neste contexto, com a diversidade das Tecnologias Digitais em Rede, dentre elas o BookCreator, o Plickers, o Kahoot e o Google Apresentações, a presente pesquisa objetivou relatar uma experiência de formação de professores buscando a dinamização da sala de aula apropriando-se desses artefatos em um colégio privado em Salvador. Concluímos que muitas são as contribuições da utilização de tecnologias para a docência, dentre elas: a melhor utilização do tempo e espaço na sala de aula.
Capital Structure and Profitability in Emerging Market New Ventures: Insights from Trinidad and Tobago
Authors: Bahaw Priscilla
Published: December 2023

New ventures, which are essential in driving economic development, face a universal challenge of accessing finance and deciding on a suitable capital structure. In developing countries such as Trinidad and Tobago, studying the impact of capital structure on profitability levels of new ventures is especially critical, given that current literature has primarily focused on established firms. To fill this gap, this study examined the existing capital structure of 43 new ventures in Trinidad and Tobago, testing the effects of different financing sources on net profit margins. The findings revealed that owners’ savings and retained earnings had a positive impact on net profit margins, while short-term loans, long-term loans, and informal investor finance had no significant effect. Moreover, this study expanded upon existing theories, particularly the pecking order theory, by testing it in the context of new ventures, rather than mature firms. The implications of this study are significant to financial managers in charge of decision-making for new ventures. It suggests the importance of owners’ savings and retained earnings in financing new ventures. Moreover, the findings suggest that new ventures in Trinidad and Tobago may benefit from pursuing funding options that align with the pecking order theory. Overall, this research emphasizes the need to consider the unique financial challenges facing new ventures when making decisions regarding their capital structure.
Studio Culture as Competency
Authors: Chee Lilian , Tan Yi-Ern Samuel
Published: December 2023

The teaching of design, the act of design itself, and its competencies are always conceived as a mystery – knowable to a certain extent yet unknowable in its totality. In studies of how design knowledge is transferred in the studio, the focus typically centers around a determinate and quantifiable pedagogical exchange between student and tutor, consistent with its etymological roots in paidagōgia, suggestive of instruction akin to the teaching of a child. Yet, we witness other kinds of exchanges and social formations in the studio that expand beyond the student-tutor exchange, more akin to the cultural transmission of a distinct set of codes, behaviors, norms, and organizations autonomous from pedagogical structures. In this paper, we shift the conversation from one solely centered around pedagogy to an orbit of the architecture studio’s culture, whose social making, we argue, produces the public body of the architecture community and is itself the competency acquired in the architecture studio.
Millî Eğitim Bakanlığı (MEB) Yönetici Seçme ve Görevlendirme Yönetmeliği Çağın Gereksinim Duyduğu Okul Yöneticilerini Seçebiliyor mu?
Authors: ÖNDER Emine , TÜRK Özgür
Published: December 2023

Bu çalışmada Batı Akdeniz Bölgesi’nde yer alan bir ilin merkezindeki devlet okullarında görev yapmakta olan okul yöneticileri ve sendika yöneticilerinin görüşlerine göre 5 Şubat 2021 tarihli Milli Eğitim Bakanlığı (MEB) Yönetici Seçme ve Görevlendirme Yönetmeliğinin çağın gereksinim duyduğu okul yöneticilerini seçme yeterliliğinin değerlendirilmesi amaçlanmıştır. Çalışmada nitel araştırma yöntemlerinden olan durum çalışması kullanılmıştır. Araştırmanın çalışma grubu, amaçlı örnekleme yöntemlerinden maksimum çeşitlilik ve ölçüt örnekleme yöntemleri kullanılarak 24 okul yöneticisi ve 10 sendika yöneticisi olarak belirlenmiştir. Ayrıca araştırmada veri toplama aracı olarak yarı yapılandırılmış görüşme formu kullanılmıştır. Elde edilen veriler içerik analizi yöntemi ile çözümlenmiştir. Araştırmadan elde edilen sonuçlar, katılımcıların çağdaş yönetici özellikleri bakımından en fazla etkin iletişim becerileri özelliğini ön plana çıkardıklarını göstermiştir. Ayrıca katılımcıların yarısından fazlası mevcut okul yöneticilerinin çağın gerektirdiği yönetici özelliklerine sahip olmadıklarını ve mevcut yönetmeliğin çağdaş yöneticileri seçebilme yeterliliğinin olmadığını dile getirmişlerdir. Son olarak katılımcılar Yönetmelik’te olması gereken özelliklere ilişkin önerilerini görevlendirmede aranacak şartlar, sınava ilişkin öneriler, seçimin yapılış şekline ilişkin öneriler, yöneticilik mesleğine ilişkin öneriler ve atama sonrasına ilişkin öneriler olmak üzere beş kategori altında ifade etmişlerdir. Bu kategoriler altında ise en fazla mülakat kaldırılmalı, seçimde paydaşların görüşleri dikkate alınmalı ve yazılı sınavın içeriği değiştirilmeli kodlarının ön plana çıktığı bulgusuna ulaşılmıştır.
Phenomenon of suppression of estrogen signaling in breast cancer cells under ultraviolet irradiation: role of Snail proteins
Authors: Sorokin D. V. , Andreeva O.  E. , Scherbakov A. M. , Salnikova D. I. , Gudkova M. V. , Krasil’nikov M. A.
Published: December 2023

Introduction. The study of the effect of irradiation or any other DNA-damaging agents on the sensitivity of tumors to conservative therapy, drug or hormonal, is among the most imporant tasks that determine the efficiency of combined therapy of cancer patients.

Aim. To investigate the effect of irradiation on the activity of key signaling proteins and the level of hormone dependence of breast cancer cells.

Materials and methods. The experiments were performed on in vitro cultured estrogen-dependent MCF-7 breast cancer cells. Ultraviolet (UV) irradiation in the range of 254 nm with the intensity of 25–50 J/m2  was used as an experimental model to study the response of tumor cells to DNA damage. Cell growth rate was determined using the MTT test, cell survival after irradiation was analyzed using the colony-forming test.  Estrogen receptor transcriptional  activity was determined by reporter assay; cellular protein expression was determined by immunoblotting.

Results. Single UV irradiation of MCF-7 cells leads to a marked increase in the level of apoptotic markers: p53, cPARP, suppression of expression of growth signaling proteins: CDK4/6 and estrogen receptor α (ERα). The above changes are accompanied with an increase in phosphorylation of Akt protein kinase and a marked increase in the expression of Snail1, one of the key proteins of epithelial-mesenchymal transition. In UV-resistant MCF-7/UVR cell subline obtained under repeated irradiation cycles, the levels of apoptotic and growth signaling proteins (p53, cPARP, CDK4/6) return to control levels, except for the phosphorylated form of Akt and Snail1, whose content  remains high. Transfection of Snail1-expressing plasmid into MCF-7 cells is accompanied by activation of apoptotic signaling, suppression of ERα activity, and development of partial hormone resistance; however, the sensitivity of cells to irradiation is practically unchanged. Transfection of microRNA-181a-2, one of the microRNAs associated with cell resistance, simultaneously activates Akt and Snail1 and leads to the development of cross-resistance of cells to irradiation and hormonal drugs.

Conclusion. The obtained data allow us to consider irradiation-induced Snail1 activation as one of the factors involved in deregulation of estrogen signaling and formation of cell resistance to hormonal drugs, while simultaneous activation of Akt and Snail1 is accompanied by the development of cross-resistance to irradiation and hormonal drugs.
Non-structural role of cytokeratins in malignant neoplasms
Authors: Boldyshevskaya M. A. , Tashireva L.  A. , Andryukhova E. S. , Dronova T. A. , Vtorushin S. V. , Perelmuter V. M.
Published: December 2023

Cytokeratins (CKs) are well studied as intermediate filaments of the cytoskeleton of epithelial cells, providing specific cell structure and morphology, in particular, apico-basal cell polarization. Meanwhile, a certain specificity of the association of CK with different types of epithelia is noted. CK heterogeneity  in the glandular epithelium is particularly pronounced and is associated with anatomical localization. The relative specificity of CKs in epithelium of different localization is preserved to a great extent in carcinomas originating from this epithelium as well. Due to this fact the determination of CK spectrum in tumor cells is quite an effective tool for nosological diagnostics of carcinomas. however, the function of CKs is not limited to providing the cell structure. The presence and amount of CK changes during the most important processes in normal and tumor cells: movement/invasion, apoptosis, proliferation, epithelial-mesenchymal plasticity.

A question arises: Is initiation of the above-listed processes happens first, and therefore CK changes are secondary and «passive», or in some processes CK changes can play a role of a trigger? Knowing the answer to this question is not only of fundamental importance, but is also important for finding ways to control the above processes by influencing the CKs.
Cellular microenvironment as an object of targeted therapy for malignant neoplasms
Authors: Zyablitskaya E. Yu. , Kubyshkin A. V. , Sorokina L.  E. , Serebryakova A. V. , Aliev K.  A. , Maksimova P.  E. , Lazarev A. E. , Balakchina A. I. , Golovkin I. O.
Published: December 2023

The dynamic relationships between tumor cells and their microenvironment are of crucial importance in the development and progression of the malignant process. Given the multifunctional potential of heterogeneous populations surrounding a tumor, targeting components of the microenvironment has long been regarded as a promising strategy in modern anticancer therapy. This review discusses the role of the components of the cellular microenvironment in carcinogenesis, analyzes in detail the main ways and mechanisms of action on the main cell populations, which are of the greatest interest in the context of the development of innovative anticancer therapy.
The Role of Value Orientations in Psychological Well-being of Adolescents: Structural Modeling Results
Authors: Radchikova N.P. , Sorokova M.G.
Published: December 2023

The study is aimed at identifying the contribution of value orientations to the psychological well-being in older adolescents. The structural modeling method (SEM) tested hypotheses about the relationship between subjective well-being, various personal characteristics and value orientations. The study involved 2647 students of professional educational organizations aged 16 to 19 years (mean age=17±1 years, median=17 years), of which 734 people (28%) were female, 1913 were male. Subjective well-being was measured using WHO-5 Well-Being Index and Ryff Scale of Psychological Well-Being. To assess personal characteristics, the Muddy hardiness test, the Tromsø Social Intelligence Questionnaire, and the BPAQ Bass-Perry Aggressiveness Questionnaire were selected. To study value orientations, Schwartz Value Survey was used. Modeling results show that values content and interrelations not only do not contribute to subjective well-being, but are also an "extra" component. The best model (TLI=0,90; SRMR=0,04; GFI=0,95; RMSEA=0,05) shows that the main contribution to the subjective well-being of a person is made by the degree of correspondence between the value orientations of the individual and the reference group (in the country, environment, etc.): if ideas about what values should be coincide with those a person has, then his/her subjective well-being increases.
Analysis of Foreign Practice in the Field of Legal Grounds and Approaches to Restriction, Deprivation of Parental Rights and Removal of a Child from His/Her Parents in Case of an Immediate Threat to His or Her Life or Health
Authors: Telitsyna A.Y.
Published: December 2023

An analysis of foreign practice in the field of legal grounds and criteria for the removal of a child from his or her family in cases of abuse, when there is a threat to his or her life or health has been carried out. At the moment the world practice demonstrates two types of systems of realization of the child's right to a safe childhood: the system of family services and the system of child protection. Demarcation is carried out according to the object whose interests are to be protected and the goals: preservation of the family and care for the mental and physical well-being of all its members in the first case, and the prevalence of the rights and interests of the child in the second. In both cases, the procedure for protecting children's rights is legal in nature, implemented by state structures with the participation of civil society. As a rule, it is carried out in the presence of social-marginalizing factors: parents' lack of economic means, parents' social deviation, drug or psychotropic substance abuse, but can be initiated against those parents who have demonstrated an aggressive and abusive attitude toward the child in society, and it has been perceived from a position of censure and disapproval, which has caused the corresponding consequences considered in this article.
Voice Cloning Using Artificial Intelligence and Machine Learning: A Review
Authors: M Inamdar Fatima , Ambesange Sateesh , Mane Renuka , Hussain Hasan , Wagh Sahil , Lakhe Prachi
Published: December 2023

This paper represents a thorough method for integrating emotions, texttospeech conversion, and state of the art voice cloning. The paper focuses on novel background noise adaptation, emotional voice synthesis, and multi-speaker voice cloning for better speech synthesis. The synthesis of emotive voices, multi-speaker voice cloning, and creative methods for modifying background noise to improve speech synthesis quality are among the topics covered in this study. Additionally, the study explores the domain of emotional artificial intelligence by adding a variety of emotions to artificial voices, improving user engagement through sympathetic reactions. The study also looks at how background noise can be altered to change it from a disturbing to a silent, non-disruptive state. The texttospeech systems usability in noisy conditions is greatly enhanced by this improvement. By integrating these components, the project makes a substantial contribution to text to speech, emotional AI, and voice cloning, creating new avenues for human-computer connection.
Financial Literacy for Personal Financial Matters: A Study of Indian Army Officers
Authors: Hooda Vikas , Pal Singh Dr Gurvinder
Published: December 2023

The basic as well as desirable needs of a person for decent survival in today’s materialistic and globalised world demand corresponding financial resources in hand. Irrespective of the profession and societal strata, individuals have their own financial aspirations and challenges. Financial literacy enables a person with understanding of financial terms and concepts besides imbibing skills, consciousness, talent and attitude to take important financial decisions. Military service having peculiar service conditions and limited exposure to financial field further makes it imperative to study the subject for inclusivity as very few studies have looked into financial issues pertaining to military personnel. The main aim of this research paper is to ascertain financial literacy of Commissioned Officers of Indian Army. For the study, 133 serving Commissioned Officers of Indian Army of varying age and length of service constituted the sample. Non-Probability technique of selecting sample has been used for the study wherein Purposive sampling is used to draw responses from the sample units. A structured questionnaire was developed to collect Primary data from serving Commissioned Officers of Indian Army. Detailed analysis has been carried out for the collected data using various tools and techniques in Microsoft Excel and SPSS. The study has brought out that financial literacy levels of serving commissioned officers of Indian Army are high. Though the demographic variables and financial literacy levels of Indian Army officers are not statistically associated, however overall high levels of financial literacy indicate their maturity of thought and quest for learning. Overall, the study outcomes indicate a healthy state for the organization and the Nation in terms of financial literacy of serving Commissioned Officers of Indian Army with respect to personal financial planning.
ANALYSIS OF THE ACTIVITY OF THE FARM "MALAINE" IN THE DAIRY FARMING SECTOR
Authors: Lene Kristīne
Published: December 2023

Milk production takes place in all EU countries and constitutes a significant part of the value of EU agricultural production. When producing and processing milk, it is important to be able to realize and maintain your economic activity with it. Therefore, the first thing that milk producers and processors do is satisfy the local demand for milk. If more milk is produced than is consumed in the given country, then it is necessary to start thinking about exports that would be able to compete with the products that are already in the planned export markets. Latvia is also on the list of countries that produce more milk than is needed for self-consumption.

The main type of activity and source of income of farm "Malaine" is side farming, but the farm is also engaged in grain farming, which helps to get additional profit in unstable years and provides its farm with high-quality feed for dairy cattle. The farm has more than 100 dairy cows. The number of dairy cows is independently increased by breeding work, selecting only the best calves from the most worthy cows.
REASONS FOR OPERATING A FOUR-WHEEL DRIVE CAR IN THE EASTERN REGION OF VIDZEME
Authors: Mežale Marika
Published: December 2023

Today, there are two opposing forces competing, on the one hand, ecology, the main aspect of which is to reduce the amount of pollution in the environment, but nevertheless, the trend of the modern world is also mobility, and the car is one of the indicators of mobility. But on the other hand, the number of sport utilitarian vehicle (SUV) cars, one of the integral components of which is four-wheel drive, is increasing. Therefore, the aim of this work is to investigate objective reasons for purchasing an all-wheel drive car and to investigate its maintenance costs in the east region of Vidzeme.
MUNICIPAL LIVING PREMISES RENT PROBLEMS
Authors: Semjonova Agita
Published: December 2023

The need for a place to live has always been a pressing problem for society. Several municipalities in Latvia are building new rental houses to provide their residents with a place to live. However, not all residents have the opportunity to apply for a municipal apartment for rent it. The problems also affect the municipalities themselves, which often end up in the role of hostages in the fight with tenants who do not pay rent, as well as when concluding rental agreements in order to fulfil the requirements of the law.
Gender characteristics of non-alcoholic fatty liver disease course
Authors: Bulatova I. A. , Shevlyukova T. P. , Tsymbal I. N.
Published: December 2023

Objective. To study the clinical picture, functional indicators of the liver, lipid spectrum, proinflammatory cytokine levels and epithelial dysfunction markers in patients with non-alcoholic fatty liver disease (NAFLD) so as to detect gender differences.
Materials and methods. Fifty-two persons with a mean age of 43.0 ± 11.1 years including 17 men (33 %) and 35 women (67 %), who suffered from NAFLD against the background of obesity were examined. The comparison group enclosed 30 practically healthy persons aged 42.3 ± 7.0 years, who had no liver pathology and obesity. The laboratory study included the assessment of functional liver tests, lipid spectrum, proinflammatory cytokine levels and epithelial dysfunction markers.Steatosis of the liver was determined with the method of ultrasonic investigation.
Results. In the examined group with NAFLD, there prevailed women (67 %). The structure of complains and concomitant pathology had no marked gender differences. The USI showed the symptoms of liver steatosis in all the patients. Among men and women with NAFLD, normal transaminase levels, cholestasis syndrome, more expressed in men, similar disorders of blood lipid spectrum were registered. The proinflammatory cytokine concentrations in the blood serum of female patients with steatosis were significantly higher than in the comparison group and among males with NAFLD. The disturbance of the endothelial angiogenic function in the form of increased vasculoendothelial growth factor concentration more pronounced in men than in steatosis women was detected (р = 0.031).
Conclusions. Among women with NAFLD, slightly expressed cholestasis syndrome, dyslipidemia, signs of systemic inflammation with increased proinflammatory cytokine concentration and disturbance of angiogenic function of endothelium were registered. In men with liver steatosis, there was identified cholestasis syndrome, dyslipidemia, and angiogenic dysfunction of endothelium, more marked than in women.
Effective treatment of septic shock using oXiris-therapy in a patient with diffuse fecal peritonitis and severe comorbid background
Authors: Kotelnikova L. P. , Vereshchagin A. V. , Sadilov M. V.
Published: December 2023

To assess the efficiency of using the methods of extracorporeal detoxification in the complex treatment of sepsis and septic shock so as to eliminate endotoxin, cytokines as well as to replace the function of organs. The article presents a successful experience of using two sessions of hemofiltration with an oXiris set for extrarenal indications in a patient with diffuse fecal peritonitis and severe comorbid background after surgery. The complex of therapeutic measures, dynamics of clinical and laboratory data before and after both sessions of oXiris therapy is presented. Positive effect of hemofiltration on the patient's condition using the oXiris set was noted 48–72 hours after the start of the procedure and 72 hours after its completion. The use of two sessions of oXiris therapy in the treatment of septic shock in a patient with diffuse fecal peritonitis and severe comorbid background allowed stabilizing hemodynamics 48–72 hours after the start of treatment; a significant improvement of a patient’s condition occurred 72 hours after the end of the second procedure.
Family clinical case of thyroid cancer in the Republic of Dagestan
Authors: Malikova B. T. , Tuchalova A. T. , Soltakhanov E. M. , Kostrova I. B.
Published: December 2023

A case of familial thyroid cancer in the Republic of Dagestan is presented. Papillary thyroid cancer was diagnosed in a sister and a brother at a young age. The disease was characterized by small size of nodes in the thyroid gland, a multi-focal lesion and the presence of metastases in the regional lymph nodes.
Clinical and pathomorphological “masks” of adrenocortical cancer. Difficulties of differential diagnostics by the example of own clinical observa-tions
Authors: Yashina D. P. , Afanasyeva Z. A. , Mazitova F. M. , Sabirov A. G. , Zhavoronkov A. E.
Published: December 2023

Difficulties in the differential diagnostics of adrenocortical cancer (ACC) are due to its heterogeneous clinical and biological behavior, which is based on a complex histogenesis and molecular genetic landscape of adrenocortical cells. In this connection, the “postulate” in the diagnosis and treatment of ACC should be a multidisciplinary approach in centers with experience in adrenal surgery and pathomorphology. The presented own clinical observations of patients with ACC diagnosed during a multiple revision of histological slides and repeated immunohistochemistry including recurrent tumor, illustrates the complexity of differential diagnosis and shows the need for further study of the subcellular mechanisms of adrenocortical oncogenesis underlying its clinical picture, morphology, and expression of valuable specific markers.
Creation of elbow joint in children with humeroradial synostosis. A clinical case
Authors: Grankin D. Yu. , Golyana S. I. , Avdeychik N. V. , Safonov A. V. , Arakelyan A. I.
Published: December 2023

Humeroradial synostosis is a severe rare anomaly of the upper limb, leading to the development of disability. This congenital anomaly may be a separate nosological unit, or a part of a genetic syndrome. Multi-stage surgical treatment is correct for all components of the deformity. The most difficult stage of treatment is the creation of an elbow joint. There are few studies on this problem in the literature. The article presents the results of surgical treatment of two children with humeroradial synostosis, who had the elbow joint created using two techniques. Patient A. underwent microsurgical transplantation of 2–3 metatarsophalangeal joints into the area of the elbow joint that had been absent since birth. Patient B. underwent total arthroplasty of the elbow joint with an individual implant. The unsatisfactory result of the treatment of patient A. is associated with the impossibility of early development of movements in the elbow joint due to the presence of axial pins. The stable position of the endoprosthesis in patient B. made it possible to conduct a course of early development of movements and get a good long-term result. Due to small number of patients, it is impossible to reliably assess the advantage of one of the presented methods. Improvement of the results of treatment in children with humeroradial synostosis requires further research.
Acute post-manipulation pancreatitis after interventions on the major duodenal papilla (experimental study)
Authors: Rantsev M. A. , Prudkov M. I. , Chupakhin O. N.
Published: December 2023

Objective. To study the morphological consequences of severe acute post-manipulation pancreatitis (APP), the morphological features of its course and the result of the compound "L-17" exposure.
Materials and methods. Rats weighing 250–300 g were used. Forty operations were performed to create a model of APP on rats. The control group included 20 rats with APP without medication, the experimental group – 20 rats with AKI against the background of "L-17" introduced in the dose of 40 mg/kg once per day.
Results. In all cases of application of this APP model in rats, the development of acute pancreatitis was noted. The conducted morphological studies showed that APP in rats in the experiment met the criteria for a severe course of acute pancreatitis with the development of purulent peritonitis and necrotizing parapancreatitis with morphological manifestations of systemic inflammation in all the organs studied (with a lethality of 70 %). The use of a new "L-17" in APP in experimental rats showed a decrease in the risk for developing both purulent peritonitis and purulent-necrotic parapancreatitis as well as a 2-fold decrease in mortality (from 70 % to 30 %). A new effect of "L-17" was revealed, i.e. prevention of necrosis of Langerhans islets. The study of the cellular composition of the inflammatory infiltrate showed a decrease in the activity of inflammatory process.
Conclusions. The efficacy of a new rat model of APP, ranked by severity, was shown. "L-17" alleviates the severity of APP, reducing the risk for developing various purulent complications and systemic inflammation.
Comparative assessment of COVID-19 incidence among healthcare workers and general population in the city of Perm
Authors: Repin T. M. , Feldblyum I. V. , Devyatkov M. Yu.
Published: December 2023

Objective. To compare the incidence of COVID-19 among healthcare workers and the general population.
Materials and methods. A retrospective analysis of COVID-19 incidence among healthcare workers and the general population was conducted using official statistics from the Center of Hygiene and Epidemiology in Perm (Russia) for the period of 2020–2022. An epidemiological descriptive and analytical method was used.
Results. During the pre-vaccination period, the disease incidence among healthcare workers exceeded that of the general population by 3.4 times. During the mass immunization period against the background of Delta strain circulation, there was a reduction in the severity of the epidemic process in both groups, while maintaining a trend towards an illness increase. When the Omicron strain appeared, there was revealed an explosive growth in the sickness rate among both healthcare workers and the general population, which was followed by a subsequent decline. Female healthcare workers had an illness rate 1.3 times higher than males. Among the afflicted healthcare workers, those aged 36–59 constituted the largest proportion. The share of infected in the group of 18–36 years and those of 60 and above was 24.7 % and 20.0 %, respectively. A similar gender and age structure of the disease was observed in the general population. The disease rate among doctors exceeded that of nurses and other medical personnel.
Conclusions. It has been established that the severity of COVID-19 epidemic process among healthcare workers reliably exceeds that of the entire population with the similarity of qualitative manifestations of the epidemic process.
Significance of interleukins and chemokines in development of vincristine polyneuropathy in children with acute lymphoblastic leukemia
Authors: Kovtun O. P. , Koryakina O. V. , Bazarnyi V. V. , Rezaykin A. V.
Published: December 2023

Objective. To analyze the content of interleukins, chemokines in plasma and liquor of children with acute lymphoblastic leukemia depending on the development of vincristine polyneuropathy.
Materials and methods. A single-center prospective cohort non-randomized study was conducted involving 131 children aged 3 to 17 years with acute lymphoblastic leukemia who received chemotherapy according to the protocol. The content of interleukins and chemokines in blood plasma and liquor was assessed with the subsequent comparative analysis of the indicators in two groups depending on the development of vincristine polyneuropathy. The level of the studied parameters was determined before the administration of chemotherapy and on the 36th day of treatment using multiparametric immunofluorescence analysis.
Results. In the studied cohort of patients vincristine polyneuropathy was registered in 80.9 % (n = 106) of patients. In the majority of cases – 84.9 % (n = 90) neurotoxic complication developed during the induction stage of chemotherapy. In the clinical picture there dominated sensory and motor disorders in 70.7 % (n = 75) of patients. The data of electrophysiologic study testified to motor axonal polyneuropathy with peroneal nerves lesion. When comparing the primary level of interleukins with their concentration after completion of the induction stage of chemotherapy, it was found that in children without vincristine polyneuropathy there was a statistically significant increase in almost all proinflammatory and anti-inflammatory interleukins. Besides, in this group high and medium direct statistically significant correlations between these cytokines were established. Especially close correlations were noted between pro-inflammatory IL-1, IL-17 and anti-inflammatory interleukins (IL-10, IL-13, IL-22 and IL-27). Additionally, in patients with vincristine polyneuropathy, a 3.7-fold increase in CXCL10 (IP-10) and a 1.4-fold increase in CXCL12 (SDF-1α) chemokines (p = 0.005 and p = 0.054, respectively) was detected in the liquor during the completion of the induction phase of chemotherapy.
Conclusions. The balanced interleukin response in children with acute lymphoblastic leukemia receiving vincristine probably reflects a link between the immune and nervous systems aimed at preventing peripheral nerve damage. An imbalance of proinflammatory and anti-inflammatory interleukins may contribute to the development of vincristine polyneuropathy. Significant increase in the content of chemokines CXCL10 (IP-10) and CXCL12 (SDF-1α) in the liquor of children with vincristine polyneuropathy gives grounds to consider them as biological markers of vincristine neurotoxicity.
Assessment of endothelial function in pregnant women with normal pregnancy and pregnancy complicated by hypertensive disorders
Authors: Padrul M.  M. , Turova E. V. , Statnykh N. V. , Cheremiskin V. P.
Published: December 2023

Objective. To assess the vascular endothelial function in the first trimester of pregnancy using the method of skin thermometry in the aspect of the development of hypertensive complications.
Materials and methods. One hundred women in the first trimester of pregnancy were examined. Based on the gestation outcomes they were divided into two groups: group 1 consisted of 80 patients without pregnancy complications, group 2 included 20 women whose pregnancy was complicated by hypertensive disorders. Clinical and anamnestic risk factors were evaluated; blood pressure level, uterine artery pulsation index, pregnancy-associated plasma protein A were measured; endothelial function was assessed using high-resolution skin thermometry.
Results. Analysis of the obtained data showed significant differences in the body mass index, systolic and diastolic blood pressure levels and values of pulsation index in the uterine arteries. An increase in the indicators during the first trimester of pregnancy was observed in patients from the group with hypertensive disorders. The results of measurements of blood flow fluctuations in the microcirculatory system showed no significant differences in the compared groups.
Conclusions. The obtained results of measuring the amplitudes of blood flow fluctuations in the microcirculatory system indicate the absence of initial endothelial dysfunction in the maternal body. However, an increase in the body weight, initial level of systolic and diastolic blood pressure, uterine artery pulsation index have an important role in predicting the development of hypertensive disorders in pregnancy.
Modern aspects of hemostasis state for fevers of rickettsiosis etiology
Authors: Bedlinskaya N. R. , Maslyaninova A. E. , Sangadzhieva V. Sh. , Shukataeva R. M.
Published: December 2023

To analyze the data obtained from scientific papers on Internet resources and to track the characteristic changes in hemostasis with various types of rickettsiosis fevers, allowing a better understanding of the pathogenesis of rickettsiosis and, as a result, a more competent approach to the treatment of this pathology. In the course of the work, numerous scientific papers of foreign and domestic scientists from various Internet resources (PubMed, CyberLeninka, Elibrari, etc.) were used, which made it possible to analyze changes in hemostasis and summarize them while working.
At the end of the twentieth century, a rapid economic development of endemic zones caused changes in their nosology, significantly affecting an increase in the incidence of natural focal rickettsiosis from the group of tick-borne spotted fevers in many regions of the world. Geographical conditions of the Volga-Caspian floodplain have created optimal conditions for the formation of natural foci of some rickettsioses on the territory of the Astrakhan region. During the period of controlled epidemiological surveillance from 1983 to 2019, the incidence rate of Astrakhan rickettsia fever has increased several dozen times, the settlements located near the gas complex are hyperendemic. The results of numerous studies regarding infectious diseases of rickettsiosis etiology indicate the leading role of cellular structures in the imbalance of hemostasis suggesting a more detailed study of their functional activity and the determination of factors affecting their activity. Rickettsioses require a more thorough study of the clinical and epidemiological picture, pathogenetic aspects to identify criteria for early diagnosis of hemocoagulation disorders in the hemostasis system that formed the basis of this study.
Thus, summing up all of the above, rickettsioses require a more thorough study of the clinical and epidemiological picture, pathogenetic aspects to identify criteria for early diagnosis and appointment of adequate therapy. The features of hemocoagulation dynamics in rickettsia fevers deserve special attention, because this process is both a trigger mechanism of the infectious process and an important factor affecting other structures of this biological system.
A Avaliação Nutricional como Ferramenta Importante para Diagnosticar a Anorexia Nervosa
Authors: Fernandes Luana , Alexandre dos Santos Elizabete , Barbosa Neto Amanda
Published: December 2023

A Anorexia Nervosa (AN) é definida como um transtorno alimentar caracterizado pelo medo intenso em ganhar peso. Este transtorno influência de maneira significativa os aspectos psíquicos e físicos dos pacientes, tendo em vista que está relacionado com a distorção da imagem corporal. Isso faz com que os pacientes façam uso de métodos extremos para evitar o ganho de peso. O diagnóstico nutricional de pacientes com AN é fundamental para que estratégias nutricionais específicas e eficazes sejam elaboradas, para tanto a avaliação nutricional é de suma importância para o nutricionista. Dessa forma, o presente estudo teve como objetivo descrever a importância do nutricionista e da avaliação nutricional para o diagnóstico da AN em adolescentes e o processo de sua reabilitação. Também serão abordados os riscos que a AN pode causar à saúde nesta faixa etária. Trata-se de uma revisão bibliográfica, com base em artigos publicados em periódicos indexados nos seguintes bancos de dados: SciELO, Pubmed e Google Acadêmico. A revisão incluiu estudos publicados nos anos de 2012 a 2022 somente na língua portuguesa. A conduta do nutricionista desde o primeiro atendimento do paciente com transtorno alimentar até a entrega de seu plano alimentar é muito delicada e muito importante. Esta envolve a aplicação da anamnese alimentar incluindo o uso da Escala de Avaliação da Figura Corporal, avaliação do consumo alimentar e do estado nutricional.
Palavras-chave: Avaliação Nutricional. Anorexia Nervosa. Alimentação. Transtorno Alimentar.
 
Abstract
Anorexia Nervosa (AN) is defined as an eating disorder characterized by an intense fear of gaining weight. This disorder significantly influences the psychic and physical aspects of patients, considering that it is related to body image distortion. This causes patients to resort to extreme methods to avoid weight gain. The nutritional diagnosis of patients with AN is fundamental for specific and effective nutritional strategies to be elaborated, therefore nutritional assessment is of paramount importance for the nutritionist. Thus, the present study aimed to describe the importance of nutritionists and nutritional assessment for the diagnosis of AN in adolescents and the process of their rehabilitation. The risks that AN can cause to health in this age group will also be discussed. This is a bibliographic review, based on articles published in journals indexed in the following databases: SciELO, Pubmed and Google Academic. The review included studies published from 2012 to 2022 in Portuguese only. The conduct of the nutritionist, from the first consultation of the patient with an eating disorder to the delivery of their food plan, is very delicate and very important. This involves the application of food anamnesis including the use of the Body Figure Assessment Scale, assessment of food consumption and nutritional status.
Keywords: Nutritional Assessment. Anorexia Nervosa. Food. Eating disorder.
Oral submucous fibrosis: Histopathogenesis
Authors: Ahmed Juveria , Puri Abhiney , Nangia Rajat , Bhat Safiya , Pasbola Akshita
Published: December 2023

Oral submucosal fibrosis (OSMF) is a precancerous condition of the oral cavity caused by the development of inflammation and fibrosis in the submucosal tissue, causing symptoms of tension and trismus. OSMF remains a concern for healthcare providers due to its easy transmission and uncertain distribution. Over the years, many classifications based on clinical, histopathological, or functional basis have been documented in the medical literature. However, none of these classifications are universally accepted. Each distribution has advantages and disadvantages. It strives to provide and update information on the OSMF classification system to help clinicians, researchers, and researchers classify these diseases for early diagnosis, and treatment time, and reducing the number of deaths. Pathogenesis and treatment are also discussed.
Management of natal teeth: A twin case report
Authors: Dutta Sharbari
Published: December 2023

Child’s evolution and growth right from conception up to the first couple of years of life is dotted with several transitions. Tooth eruption is one such phenomena which follows a chronology corresponding to the age of the child at which the tooth appears in the mouth. The exfoliation timeline has been documented in the literature but may vary based on several factors including hormonal, hereditary, and environmental. However, sometimes the eruption sequence undergoes a more drastic alteration where the first teeth may be present in the mouth at the time of birth or erupt within the first thirty days after birth. This paper was written with the aim to discuss the etiologic factors, clinical features, complications, and management of such natal or neonatal teeth, as well as their role in sublingual ulcer formation and discomfort during breastfeeding.

Two cases are discussed where newborns, a 10-day old male, and a 7-day old female with a mandibular incisor natal tooth had reported to the Department of Pedodontics and Preventive Dentistry at Kalinga Institute of Dental Sciences. The teeth were extracted as they were mobile and there was fear of aspiration and refusal to feed.

Extraction of the natal tooth accelerated healing of ulcers and relief from discomfort during breastfeeding.