bluuebunny/crossref_metadata_2025 huggingface dataset:
The Impact of a Common Currency on the European Union
Authors: Abraham Mensah  , Ayooluwa Tomiwa Animashaun
Published: April 2024

This study examines the ramifications of adopting a common currency within the European Union (EU), focusing on introducing the euro. Initially prompted by optimistic expectations of economic stimulation and balanced budgets, the research critically assesses the economic, trade, and policy dimensions associated with a unified currency. Utilizing Mundell's optimal currency regions concept, the methodology establishes prerequisites for a successful monetary union, emphasizing vulnerability to macroeconomic shocks, labor market flexibility, and intra-regional commerce. Findings reveal that while a common currency eliminates foreign exchange expenses, reduces uncertainty in bilateral exchange rates, and facilitates investments, member states must sacrifice autonomy in monetary and exchange rate policies. The advantages include streamlined cross-border payments, enhanced trade, and improved movement of labor and products, while the drawbacks involve rigid monetary policies and limitations on policy tailoring to specific economic conditions.

To maximize benefits, the research proposes measures such as deepening economic integration, ensuring macroeconomic stability, and promoting political unity. The study emphasizes the importance of sound economic policies to complement the adoption of a common currency and mitigate potential challenges. In conclusion, the research offers a comprehensive understanding of the advantages and disadvantages associated with a common currency in the EU, providing a roadmap for effective navigation and suggesting interventions to ensure successful implementation.
The Executive Authority and Public Policies in Jordan towards Local Government: Relationship and Roles, a Theoretical Study
Authors: Mohammed Al Mogdad
Published: April 2024

The study aims to discuss the reality of local councils in Jordan in terms of their origin, responsibility, and repercussions on the local community. It also explains the impact of the role of the executive authority on the performance of middle administrations and reviews the impact of the electoral system on the reality of the achievements of municipal and governorate councils (decentralization and the extent to which the local administration sector in Jordan contributes to Various areas of development, thus revealing the most important challenges that still face local councils.The study is based on the main hypothesis: "There is a correlation between the role and influence of public authority in Jordan and the limited outputs of local administrations and councils in the process of sustainable development." The study used each of the analysis systems, institutional and functional approaches.Finally, the study concluded several results, the most prominent of which is the existence of a gap between public policy strategies and plans related to the roles of middle administrations and local councils and the ability to reach sustainable development in Jordan.
A Critique of Blue Ocean Strategies: Exploring the Limits of Creating Uncontested Markets
Authors: Dr. Justice Mutua J.N.  , Catherine N. Wangari
Published: April 2024

Blue ocean strategies aim to shift an organization's competitiveness to significant heights of market creation, business growth, and confidence. This paper critically examines the Blue Ocean Strategy (BOS) model proposed by Kim and Mauborgne (2005). While captivating for its promise of creating uncontested markets and achieving significant competitive advantage, the model exhibits limitations in its implementation protocol, scientific validation, and practical applicability. This critique analyzes the core BOS concepts of value innovation, humanness, competitor elimination, and customer acquisition, highlighting their theoretical deficiencies and practical challenges. The study concludes that the Blue Ocean strategic model lacks a clear implementation protocol and procedure in general, which has presented practical doubts over its applicability. Drawing from existing research and empirical evidence, this paper recommends further research and refinement of the BOS model to enhance its rigor and practical utility.
Public Financial Management (PFM) Laws and Audit Quality in Ghana: The Moderating Role of Auditor-Client Relationship
Authors: Amofa-Sarpong, Kwabena  , Dr. Tornyeva Kingsley
Published: April 2024

Purpose: This study examines the extent to which public financial management (PFM) laws contribute to audit quality in the public sector and how the auditor-client relationship moderates this effect.

Design/Methodology/Approach: This study used a quantitative survey research design to collect data from about 400 public sector auditors working with Ghana's Supreme Audit Institution (SAI), the Audit Service, by adopting the contextual factor of the IAASB's framework for Audit Quality using the PLS-SEM method of analysis.

Findings: The study found that in the Public Sector, Public Financial Management (PFM) laws positively influence audit quality, while auditor-client relationships also negatively contribute to audit quality.

Furthermore, it was also established that the auditor-client relationship negatively moderated the relationship between Public Financial Management (PFM) laws and audit quality.

Implications/Research Limitation: The results of this study extend and add to the growing empirical studies on Public Financial Management (PFM), audit quality and the field of public sector auditing. However, the study will be limited to only public sector auditors working with Ghana's Supreme Audit Institution (SAI), the Audit Service.

Practical Implication: The study results have the prospect of encouraging policy-makers to strengthen the independence and improve the capacity of the State Auditor (i.e. Ghana Audit Service) through appropriate PFM laws that seek to improve auditor-client relationships through relevant compliance and enforcement mechanisms.

Originality/Value: This study is the first to directly examine how the Public Financial Management (PFM) laws contribute to audit quality in Ghana and how the auditor-client relationship moderates this effect.

Nevertheless, this study differs from other prior empirical research on the basis of the method employed and the context of the study.
Assessment of Urban Dwellers on the Use of Selected Social Media Platforms in Propagating the Knowledge of Parkinson's Disease in Ebonyi State, Nigeria
Authors: Ikelle Ada Precious  , Ilang Chukwuma Iteshi  , Ogbuoshi Linus
Published: April 2024

This paper examined the assessment of urban dwellers on the use of selected social media platforms in propagating the knowledge of Parkinson's disease in Ebonyi state, Nigeria. Three research objectives, three research questions and two null hypotheses guided the study. The study adopted a descriptive survey research design and used a questionnaire structured by the researcher for data collection. A sample of 384 respondents was selected from the population of 851,186 in Ebonyi using a purposive sampling technique. The instrument for the data collection was face and content validated by three experts from the Department of Mass Communication who vetted it in terms of the coverage and adequacy of the contents of the questions. The reliability of the instrument was determined by subjecting it to a test of reliability in a trial testing using 20 respondents from Benue State, which was not part of the study area. The data collected were used to determine the reliability coefficient using the Cronbach alpha approach in the statistical package for social science (SPSS). The analysis gave the coefficient index of 0.81. The instrument was administered to the respondents with the help of three (3) research assistants who were graduates from the Department of Mass Communication and considered to have good knowledge of the area of study as well as requisite skills and ideas needed for the administration of the questionnaire. Data collected were analyzed using percentages, mean and standard deviation. Percentage was used to present the demographic data while research questions were answered using mean and standard deviation, and the hypotheses were tested using regression at a 0.05 level of significance. The findings revealed that urban dwellers use the selected social media to propagate knowledge of events to a high extent; the selected social media platforms were used to propagate the knowledge of Parkinson's disease among urban dwellers to a low extent, and the aspects of knowledge of Parkinson's disease that the selected social media platforms were used to propagate among urban dwellers in Ebonyi state, Nigeria are meaning of Parkinson's disease, causes of Parkinson's disease and symptoms of Parkinson's disease. The study recommended, among other things, that the health sector, active smartphone users, government, non-governmental organizations, and other concerned groups should use different mechanisms to sensitize the public on the importance or benefits of using social media platforms for propagating knowledge of Parkinson's diseases.
Remittances, Debt Service Payments and Economic Growth in Nigeria
Authors: Yussuff, Rukayat Omobolanle  , Israel Emmanuel
Published: April 2024

The study investigates the intricate relationship between the effects of remittances (REMIT) and debt service payments (DSP) on economic growth (RGDP) as well as other key variables, external reserve (ER), foreign direct investment (FDI), and external debt (EXTD) on economic growth (RGDP) in Nigeria from 1995 to 2021. Various statistical techniques, such as Ordinary Least Square (OLS), Augmented Dickey Fuller (ADF) tests and ARDL, were used. The result indicates the existence of a positive correlation between RGDP and FDI; DSP and ER exhibit a moderate negative correlation, while REMIT and DSP show a strong negative correlation. ER and REMIT indicate a correlation, while EXTD and ER indicate a negative correlation. All variables are I(1) and the ARDL Bound test for co-integration indicates that a long-run relationship exists between dependent and independent variables. ARDL estimation shows that only the coefficient of external debt is significant. The R2 shows that 84% of the variation in RGDP is explained by the independent variables. The test for autocorrelation (DW = 2.33) indicates no autocorrelation in the error term.

This study recommends that policymakers should implement measures to attract and retain foreign investments, given the positive impact of FDI on RGDP, and Policymakers should explore strategies to channel remittances into productive sectors, such as investments in infrastructure, education, and small-scale enterprises.
Business Analytics: From Big Data to Brief Details
Authors: Babalola, Olanrewaju Emmanuel  , Folorunso, Esther Oluwabusayo
Published: April 2024

Undoubtedly, technology has made the world a global village and created a fast-paced environment. This is accompanied by a plethora of data amidst limited time. To arrive at an informed and relevant decision, the numerous data needs to be fully optimized, and this is where business analytics comes in. Business analytics simply stands in the gap to ensure all data sets are efficiently utilized into concise and relevant information for the users. This paper provides an overview of business analytics, including its history and current trends, the methodologies, techniques, and relevant analytical tools used in the field, and its application to real-world business problems. This paper seeks to explore relevant analytical tools and practices that translate big data into brief details without "hiding" the actual data sets in the business world.
Adverse Childhood Experiences
Authors:   Licensed Mental Health Counselor, WH James
Published: April 2024

This paper examines the role of Adverse Childhood Experiences on adolescent development. Adverse Childhood Experiences are significant early traumas that affect brain development and can lead to serious physical, mental and emotional issues if left unaddressed. Incorporating evidence from literature reviews, this study demonstrates that these issues can be addressed by nurturing resilience into the lives of children and adults.
Community Response to Internet Addiction among Minors: An Overview, Findings, Challenges
Authors:   Fudan University, Jieli Wu
Published: April 2024

Purpose: The article aims to explore the nature and characteristics of minors' Internet addiction behavior, and analyze the comprehensive factors as well as the diverse effects based on the deviant behavior theory. The deviant behavior theory, integrating misconduct with sociocultural concepts, social values, and norms, can provide new insight into the existing theoretical research on this issue.
Politics and Substance Use Disorder an Unexpected Vote Result for HR 4531
Authors:   FNAP, G Smith Robert
Published: April 2024

Background: Substance use disorders occur when the recurrent use of alcohol and/or drugs causes clinically significant impairment, including health problems, disability, and failure to meet major responsibilities at work, school, or home.
The global gas transit: new supply chains
Authors: Zhiltsov S. S.
Published: April 2024

The aggravation of relations between Russia and Western countries in early 2022 has marked the formation of new supply chains for energy resources, particularly gas exports. Global energy transit is closely linked to fundamental problems in the world economy, which were aggravated during the coronavirus pandemic. Empirical evidence illustrates that new hydrocarbon supply chains have dramatically changed the balance of power in the global market. The reasons for this were the pricing policy as well as the supply and demand conditions in the market. Considering the gas market as a system of interrelated participants: producers and consumers, the study concludes that energy transit will be determined by the outcome of the economic competition between Russia and the West, as well as the speed of building the infrastructure necessary for the creation and transportation of liquefied natural gas. At the same time, the prospects for low-carbon energy are not so obvious. First of all, the high costs and the unwillingness of many countries to make significant investments hamper a transition. The study concludes that the restructuring of global energy supply chains is in the interests of some developed countries. In general, the current processes in the global energy sector represent a fundamental trend that is associated with the transition period of the world economy. The paper contributes to the knowledge by providing a comprehensive overview of the new processes in the energy sphere.
Arctic cinema: War films, detective stories and comedies
Authors: Zonn I. S.
Published: April 2024

This third article examines such genres of cinema as war films, detectives and comedies the latest in the line of Arctic films. Thereby we draw a line under Arctic films, that have not received due attention from film critics and the public until now. The need to return to the past to take a fresh look at the solar, including its storyboard, taking into account the deep rethinking of the war and the direct depiction of what was experienced, to show a truthful and accurate image of the war on the example of the fate of one or many of its participants. Cinematographers constantly return to the theme of the war, its individual episodes, the people who took part in it, who noted their heroism in it, its new reading caused by changing socio-political views and access to previously censored circumstances, what is now called «trench truth».

«Another war» in pleacetime was reflected in the Arctic detectives. The enemy appears in them as criminal elements, sometimes was sophisticated and insidious plans, which in the conditions of the north require a special approach to solve then. Comedies have no geographical boundaries. Humor and laughter in the snow and ice is special, very often associated with the behavior of animals, especially dogs.
Ockham nominalista?
Authors: Herrera Restrepo Daniel
Published: April 2024

Resumen
Hacia una teoría lingüística elemental
Authors: Baena Luis Angel
Published: April 2024

Resumen
La utilización del dictado en la enseñanza del francés
Authors: Lopez Mancilla Jairo
Published: April 2024

Resumen
GRAVIDADE DOS SINTOMAS DA COVID-19 E QUALIDADE DE VIDA NA COVID LONGA: QUAL A RELAÇÃO EM ADULTOS E IDOSOS?
Authors: Silva de Moraes Tais Nayara , Lopes da Silva Lorena Caroline , Cardoso Gilmar Junio Alves , Aguiar Jhully Souza Garcia , Baldan Cristiano Schiavinato , Fonseca Daniela Rosana Pedro , Matsunaga Natasha Yumi
Published: April 2024

Avaliar a relação entre gravidade dos sintomas da Covid-19 e qualidade de vida na Covid Longa em adultos e idosos. Trata-se de estudo transversal, prospectivo e multicêntrico, realizado com indivíduos com idade superior á 18 anos com Covid Longa, de ambos os sexos, acompanhados nas Clínicas Escolas da Universidade Paulista – UNIP. Foi aplicado uma ficha de avaliação, no qual foram coletadas informações como, dados pessoais, história clínica da Covid-19, e manejos da doença em relação a necessidade de oxigenoterapia, ventilação mecânica não invasiva (VNI) e invasiva (VM) e traqueostomia (TQT), bem como o questionário SF36 versão Brasileira. A pesquisa foi submetida e aprovada pelo CEP da Universidade Paulista – UNIP, parecer 4.894.652. Os adultos e idosos que foram internados tiveram pior qualidade de vida nos domínios capacidade funcional, vitalidade e saúde mental. Aqueles que utilizaram oxigenoterapia, VM e TQT, tiveram maior acometimento no domínio saúde mental e os indivíduos que utilizaram a VNI, tiveram pior pontuação no domínio capacidade funcional. Conclui-se que adultos e idosos com Covid Longa apresentaram pior qualidade de vida à longo prazo, sobretudo naqueles com maior gravidade dos sintomas da Covid-19, ou seja, que necessitaram de internação, oxigenoterapia, VNI, VM e traqueostomia.
Digital communication of the Bank of Russia in social media
Authors: Shcheglov Maksim Yur'evich , Pashkus Vadim Yur'evich
Published: April 2024

The subject of this study is digital communication of the Bank of Russia in social media. The relevance of the article is determined by the role and significance of modern digital communication channels in everyday life and the potential for their use in ongoing monetary policy. The authors systematize and summarize scientific articles devoted to the connection between effective communication and monetary policy pursued by central banks. The article notes that successful central bank communication should make monetary policy more predictable and market expectations about future rates more accurate. The purpose of the current article is to assess the readability of digital materials published by the Bank of Russia on official social networks and instant messengers. To assess the readability of digital publications, the authors identify two large audience groups: professional and non-professional. As a text analysis method, the authors rely on syntactic and lexical methods and use the Flesch-Kincaid index and Fog-Index as indicators of text readability. The authors presented the key channels and communication tools of central banks, and also highlighted the main channels of digital communication of the Bank of Russia: the Bank of Russia website, social media and the Bank of Russia application “Central Bank Online”. Each of the channels has both direct and indirect affiliation. The results of the direct affiliation channel of social media and the website emphasize the positive dynamics of readability indices – materials published on social networks by the Bank of Russia become clearer to a wider audience segment. However, most publications still require specialized training in economics and finance to fully understand the information. Thus, in communication on social networks, the Bank of Russia’s focus is on reaching a non-professional audience in order to increase transparency and the level of trust in its monetary policy.
Transtornos relacionados ao uso de opioides
Authors: Silva Emanuele Regina Cerqueira Texeira , Moura Marcela Mamede de Araújo , Siqueira Emílio Conceição de
Published: April 2024

Objetivo: Analisar as características do Transtorno por uso de Opioides (OUD). Revisão bibliográfica: Os opióides são amplamente prescritos para pacientes dor crônica, oncológica e dor aguda em internados e intervenções pós-cirúrgicas. O aumento na prescrição desses agentes levou a umacrise dos opioides nos Estados Unidos com preocupação mundial, pois estes fármacos podem causar dependência e mortes por overdose. O OUD é o uso crônico de opioides que causa sofrimento ou prejuízo clinicamente significativo que consiste em um desejo irresistível de usar opióides, aumento da tolerância e síndrome de abstinência quando descontinuado. Este transtorno afeta cerca de 510 pessoas por 100.000 habitantes mundialmente. Considerações finais: Dado o incremento na utilização dos opioides, sua crise e o potencial dessas drogas para dependência, uso indevido e overdose é fundamental sua prescrição a pacientes selecionados, em doses restritas e com o adequado aconselhamento acerca do uso com segurança de modo que haja monitorização dos seus efeitos em cada indivíduo. Além disso, para tratamento da dor devem ser priorizadas outras classes de analgésicos e terapia não farmacológica. Deve haver também controle dos órgãos de saúde sobre a prescrição e venda desses medicamentos, a fim de coibir o comércio ilegal.
Extremity Myxoid Liposarcoma: Prognostic Factors and 20-Year Survival Outcomes
Authors:   Department of Orthopaedic Oncology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain, P Machado , A Peiró ,   Department of Orthopaedic Oncology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain, L Trullols ,   Department of Orthopaedic Oncology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain, A Sebio ,   Department of Orthopaedic Oncology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain, R Orellana ,   Department of Orthopaedic Oncology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain, I Gracia ,   Department of Orthopaedic Oncology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Published: April 2024

Introduction: Myxoid liposarcoma (MLS) is a rare, malignant musculoskeletal tumour. Due to the rarity of MLS, the factors associated with survival remain only partially understood. The aim of this retrospective study was to identify prognostic factors in patients with extremity MLS treated at our centre. Methods: We reviewed the clinical records of 60 patients with extremity MLS treated at our hospital from 1997 to 2017. We evaluated patient- and tumour-related characteristics, as well as diagnostic and therapeutic procedures to determine their association with clinical outcomes, including local Recurrence-Free Survival (RFS), Metastasis-Free Survival (MFS) and Overall Survival (OS). Survival data were analyzed with the Kaplan-Meier method. Multivariate analyses were performed with Cox proportional-hazards regression. Results: Overall survival at 5 years was 91%. On the multivariate analysis, surgical margins were an independent risk factor for MFS (Hazard Ratio [HR]: 10.98, 95% Confidence Interval [CI]:2.59-46.46), local RFS (HR: 9.34, 95% CI: 1.75-49.68), and OS (HR: 27.90, 95% CI: 5.01–155.50) (all p=0.001). Revision surgery was significantly associated (p=0.001) with higher local recurrence rates (HR: 99.13, 95% CI: 6.90–1423). Conclusions: Surgical margins were an independent risk factor for MFS, local RFS, and OS. The need for revision surgery due to an unplanned excision was strongly associated with an increased risk of local recurrence, but not with MFS or OS. These findings underscore the importance of achieving clear surgical margins, especially in patients undergoing second-look surgery.
Ice Cream Cone Pelvic Reconstruction after Peri-Acetabular Tumour Resection - Institutional Experience and Description of Implant Fatigue Failure
Authors:   Department of Trauma & Orthopaedic, Glasgow Royal Infirmary, Glasgow, Scotland, Hailemeskel Ermias , Jayasankar Viswanath ,   Department of Trauma & Orthopaedic, Glasgow Royal Infirmary, Glasgow, Scotland, Fraser Ewen ,   Department of Trauma & Orthopaedic, Glasgow Royal Infirmary, Glasgow, Scotland, Gulia Ashish ,   Department of Trauma & Orthopaedic, Glasgow Royal Infirmary, Glasgow, Scotland, Mahendra shish ,   Department of Trauma & Orthopaedic, Glasgow Royal Infirmary, Glasgow, Scotland, Gupta Sanjay ,   Department of Trauma & Orthopaedic, Glasgow Royal Infirmary, Glasgow, Scotland
Published: April 2024

Aims: Reconstruction following resection of tumours involving the peri-acetabular area is challenging. Achieving acceptable long-term functional status remains difficult and complications are common. The aim of this study was to describe our experience of using the Stanmore ice-cream cone implant after major pelvic tumour resection and present 2 unique cases of implant fatigue failure. Methods: Ten patients with primary pelvic tumours involving the peri-acetabular region were treated with resection (type 2/2+3) and reconstruction using the Stanmore ice-cream coned pelvic implant between 2010 and 2019 at our centre. Retrospective analysis of our database and patient records was carried out to identify outcomes and complications. Results: Seven male and three female patients with a mean age of 46 years (range- 17-74 years) were treated with reconstruction using the Stanmore ice-cream cone implant. Chondrosarcoma (n=7) was the most common diagnosis. At a mean follow up of 67 months, 7 patients were alive without disease, 1 patient developed metastatic disease and 2 patients died of recurrent/metastatic disease. Dislocation occurred in 2 patients and 1 patient developed deep infection requiring re-operation for local control. Two patients developed fatigue failure of the implant, which has not been described in the literature. No revision was performed at the time of study. Conclusion: Reconstruction after peri-acetabular tumour resection remains challenging with high rates of complications. Surgical techniques and implant options are evolving but the ideal implant is yet to be established. Patients should be advised about potential complications including the need for further treatment related to implant failure.
Interobserver Variability in Interpretation of VQ SPECT and its Impact on Patient Management
Authors:   Department of Molecular Imaging and Therapy, Austin Health, Melbourne, VIC Australia, RR Boktor , A Poon ,   Department of Molecular Imaging and Therapy, Austin Health, Melbourne, VIC Australia, SU Berlangieri ,   Department of Molecular Imaging and Therapy, Austin Health, Melbourne, VIC Australia, A Tauro ,   Department of Molecular Imaging and Therapy, Austin Health, Melbourne, VIC Australia, ST Lee ,   Department of Molecular Imaging and Therapy, Austin Health, Melbourne, VIC Australia, S Gong ,   Department of Molecular Imaging and Therapy, Austin Health, Melbourne, VIC Australia, SS Thomas ,   Department of Molecular Imaging and Therapy, Austin Health, Melbourne, VIC Australia, AM Scott ,   Department of Molecular Imaging and Therapy, Austin Health, Melbourne, VIC Australia
Published: April 2024

Background: Pulmonary Embolism (PE) is a major cause of morbidity, mortality and hospitalization. Ventilation Perfusion lung scan (VQ) is a powerful tool in diagnosing PE. It has been noted that there are some variations between highly experienced physicians in interpreting VQ SPECT due to lack of widely accepted reporting guidelines. Aim of the Study: Is to measure the interobserver variability in interpreting VQ scans, and then re-measure it again after applying standardized guidelines. Methods: Two cohorts of patients were included in this study the first included 347 patients and the second 290. Interobserver variability between 4 experienced physicians was measured on the first cohort and re-measured on the second cohort after applying 10 points agreed standardized guidelines. Results: Showed substantial increase in the percentage of agreement between all the physicians after applying the agreed 10 points standardized diagnostic criteria. This was apparent in all the categories with the highest agreement achieved when comparing 2 physicians. Kappa value increased from 0.346 to 0.4665 between the 4 Physicians, from low 0.3 to high 0.4 range between 3 Physicians and from as low as 0.2762 to the maximum of 0.5516 between 2 physicians. Unclassified number decreased between the 2 cohorts from 16.5% to 8% and subsequently decreasing false positive cases from 7.5% to 1.7%. Conclusion: Adherence to reporting guidelines increases the interobserver agreement in interpreting VQ SPECT leading to better patient outcomes and increased referrer confidence in reporting VQ SPECT.
Summary of Research and Development Progress of Oncolytic Viruses
Authors:   Institute of Bioengineering, Biotech Pharma Ltd, Beijing, China, Tian Pengpeng , Lu Honghong ,   College of Science and Technology, Beijing Open University, Beijing, China
Published: April 2024

Oncolytic viruses are viruses that have been genetically modified to specifically infect and kill cancer cells. They have significant potential in the field of cancer therapy because they possess many advantages over traditional treatments, such as selective killing of tumor cells, increasing the immunogenicity of tumor cells, and avoiding the side effects of chemotherapy and radiotherapy. Currently, several oncolytic viruses have shown good safety and efficacy in clinical trials. More combination therapy strategies are being explored, and it is expected that oncolytic viruses will be more widely used in cancer treatment in the future.
The Role of COVID-19 Pandemic on Malaria Incidence; Meta-Analysis and Systematic Review Study
Authors:   Department of Medical Microbiology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran, Jalili Mahsa , Abolhasani Fatemeh Sadat ,   Department of Microbiology, Faculty of Biological Sciences, Alzahra University, Tehran, Iran, Afkhami Hamed ,   Nervous System Stem Cells Research Center, Semnan University of Medical Sciences, Semnan, Iran, Sharifi Somayeh ,   Department of Medical Microbiology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran, Zadeh Ali Noori ,   Department of Clinical Biochemistry, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran, Shafiei Morvarid ,   Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran
Published: April 2024

Background: Today, COVID-19 and malaria are the leading causes of death in the worldwide. Malaria and COVID-19 have common aspects and may be was a high potential for mutual influence. Hence, consequences and outcomes of COVID-19 become very dangerous and problematic. The aim of this study, investigate of the influence of COVID-19 mortality and malaria prevalence by systematic review and meta-analysis study. Method: We searched authentic research databases by using the following keywords in English language. In additional, for statistical analysis, meta-analysis and random effect model and I2 index were used. Statistical analysis was performed with STAT (version 11.2). Result: In the present study, nine articles were selected from 1,014 articles that examined co-infection in COVID-19 and malaria. This study revealed that co-infection between malaria and COVID-19 has very interesting and surprising results. OR (odds ratio) =-1.2 (95% CI: -1.8 to -0.6). We encounter high values of I2 in the study (l2=98.549). Conclusion: People with malaria who show symptoms such as fever should be evaluated by COVID-19 to prevent serious complications. The present study provided information on malaria and COVID-19 co-infection. Nevertheless, further prospective studies are needed to investigate the burden and consequences of COVID-19 in malaria endemic areas.
Flash Sequence-Defined Molecular Synthesis Enabled by Living Anionic Monoaddition of Polymerizable Alkenes
Authors: Okamoto Kazuhiro , Yoo Dong-eun , Yoshioka Rikako , Nakasato Ryohei , Ashikari Yosuke , Kitayama Kenji , nagaki aiichiro
Published: April 2024

The selective monoaddition of polymerizable vinyl monomers like styrenes and methacrylates in a living manner has been achieved for the flash-flow preparation of molecules in a defined sequence with high selectivity. We demonstrated the sequence-defined synthesis of multifunctional molecules using an initiator, functionalized styrenes, diarylethylenes, various methacrylates, and an electrophilic trapping reagent at the living terminus (six-component sequential connection at maximum) without any intermediate purification steps. The anionic living terminus of the vinyl monomers in the flow system described herein is active for polymerization, such that the styrene or methacrylate sequence can be expanded to afford highly dispersed oligomers without affecting other single units, which means that the unequivocal sequences were successfully inserted into the internal or terminal positions. The methodology described herein provides an adaptable method for the construction of new molecular spaces based on unimolecular sequence control and pinpoint functionalization.
Leveraging Triphenylphosphine-Containing Polymers to Explore Design Principles for Protein-Mimetic Catalysts
Authors: Sanders Matthew , Chittari Supraja , Foley Jack , Swofford William , Elder Bridgette , Knight Abigail
Published: April 2024

Complex interactions between non-coordinating residues are significant yet commonly overlooked components of macromolecular catalyst function. While these interactions have been demonstrated to impact binding affinities and catalytic rates in metalloenzymes, the roles of similar structural elements in synthetic polymeric catalysts remain underexplored. Using a model Suzuki-Miyuara cross-coupling reaction, we performed a series of systematic studies to probe the interconnected effects of metal-ligand cross-links, electrostatic interactions, and local rigidity in polymer catalysts. To achieve this, a novel bi-functional triphenylphosphine acrylamide (BisTPPAm) monomer was synthesized and evaluated alongside an analogous monofunctional triphenylphosphine acrylamide (TPPAm). In model copolymer catalysts, increased initial reaction rates were observed for copolymers untethered by Pd complexation (BisTPPAm-containing) as compared to the Pd-cross-linked catalysts (TPPAm-containing). Further, incorporating local rigidity through secondary structure-like and electrostatic interactions revealed nonmonotonic relationships between composition and reaction rate, demonstrating the potential for tunable behavior through secondary sphere interactions. Finally, through rigorous cheminformatics featurization strategies and statistical modeling, we quantitated relationships between chemical descriptors of the substrate and reaction conditions on catalytic performance. Collectively, these results provide insights into relationships between composition, structure, and function of protein-mimetic catalytic copolymers.
Emerging conformational analysis protocols from the RTCONF-16K reaction thermochemistry conformational benchmark set
Authors: Mészáros Bence Balázs , Kubicskó Károly , Németh Dávid Dorián , Daru János
Published: April 2024

Here, we provide a new, realistic reactive conformational analysis benchmark set (RTCONF-16) based on state-of-the-art and cost-efficient methods to assess different protocols. Our comprehensive reference calculations were used to underpin the accuracy of the CENSO (JPCA, 2021, 4039) procedure and to provide alternative recipes with different cost-accuracy compromises. Our general-purpose and economical protocols (CENSO-light and zero, respectively), were found to be 10-30 times faster than the original algorithm while adding only 0.4-0.7 kcal/mol absolute error to the relative free energy estimates.
Current and projected demand for nurses working in general practice in Ireland
Authors:   ESRI, Connolly Sheelah , Flanagan Ellen ,   ESRI
Published: April 2024

General practice is an integral part of the Irish healthcare system. Demand for general practice services is expected to increase in the coming years due to both (i) a growing and ageing population, and ii) policy proposals seeking to re-orientate healthcare delivery towards the community setting. Consequently, there is a need to increase the general practice workforce to deliver on this projected increase in demand. The number of GP training places have increased in the last number of years; however an increase in the number of nurses working in general practice could also help address growing demands on the sector. The aim of the research in this report is: To examine the current utilisation of practice nurse services in Ireland. To make projections about the future demand for practice nurse services. To identify challenges and potential facilitators to increasing the number of nurses working in general practice in Ireland.
Regional Economic Sentiment: Constructing Quantitative Estimates from the Beige Book and Testing Their Ability to Forecast Recessions
Authors: Filippou Ilias , Garciga Christian L. , Mitchell James , Nguyen My T.
Published: April 2024

We use natural language processing methods to quantify the sentiment expressed in the Federal Reserve's anecdotal summaries of current economic conditions in the national and 12 Federal Reserve District-level economies as published eight times per year in the Beige Book since 1970. We document that both national and District-level economic sentiment tend to rise and fall with the US business cycle. But economic sentiment is extremely heterogeneous across Districts, and we find that national economic sentiment is not always the simple aggregation of District-level sentiment. We show that the heterogeneity in District-level economic sentiment can be used, over and above the information contained in national economic sentiment, to better forecast US recessions.
Turismo, stakeholders e fluxo informacional: panorama bibliométrico de pesquisa
Authors: Silva Luiza da , Rangel Brendha , Medaglia Juliana
Published: April 2024

A relação entre informação e turismo ocorre de maneira essencial quando se trata do desenvolvimento sustentável e da gestão da atividade turística, quer seja nas escolhas de viagens por parte dos turistas ou especialmente no âmbito da tomada de decisão pelos stakeholders do turismo de determinada localidade. Assim, o trabalho se propõe a compreender como a relação entre os constructos turismo, stakeholders e fluxo informacional está sendo abordada na literatura, tendo como contexto o turismo sustentável. Para isso, optou-se por empregar a bibliometria, a partir de descritores: turismo, stakeholders e fluxo informacional, coletados na Web of Science (WoS). Como principais resultados, é possível dizer que 2021 foi o ano que mais houve produção científica sobre os temas “turismo e stakeholders” e “stakeholders e fluxo informacional”, demonstrando atenção relativamente recente, indicando escopos de pesquisa que ainda podem ser mais explorados. Além disso, indo ao encontro do escopo inicial da pesquisa, a Revista Sustainability é a que mais publica estudos envolvendo estes constructos. Por fim, poucos estudos tratam da compreensão dos três constructos (turismo, stakeholders e fluxo informacional) de forma conjunta, indicando uma lacuna teórica ainda inexplorada.
Projeto e validação do questionário de autodiagnóstico sobre competências digitais para grupos vulneráveis (ACOMDIG).
Authors: López-García Alejandro , Guerrero-Romera Catalina , Zaragoza Vidal María Victoria , Vera-Baceta Miguel Ángel
Published: April 2024

A avaliação das competências digitais envolve qualquer processo para determinar o grau de aptidão que uma pessoa possui com relação ao uso da tecnologia digital, bem como sua capacidade de aplicar eficientemente esse conhecimento em diferentes contextos da vida. Com a revolução digital, os desafios tecnológicos podem evidenciar lacunas e dificuldades que agravam as desigualdades e os problemas sociais, principalmente em grupos vulneráveis. O objetivo deste estudo é elaborar e validar um questionário de autodiagnóstico baseado no nível de competências digitais de mulheres migrantes, de acordo com o European Digital Competences for Citizenship Framework (DigComp). Quanto ao método, foi aplicado um projeto misto, usando uma abordagem quantitativa com uma análise descritiva do conteúdo e uma medição da estrutura fatorial do instrumento, e uma abordagem qualitativa por meio de um refinamento do questionário, levando em conta as observações feitas em uma discussão de grupo focal. Como resultado, o instrumento apresentou propriedades psicométricas adequadas para coletar informações válidas e confiáveis. Para concluir, é apresentada a versão final do questionário, intitulada Autopercepção do nível de desempenho em Competências Digitais (ACOMDIG).
A newly developed random walk model for PCS network
Authors: Islam Imdadul
Published: April 2024

Different types of random walk models are prevalent in mobile cellular network for analysis of roaming and handover, being considered as important parameters of traffic measurement and location updating of such network. This paper proposes a new random walk model of hexagonal cell cluster, exclusively developed by the authors and a comparison is made with two existing models. The proposed model shows better performance in context of number of probability states compared to existing models.
Performance and operation of stressed dual gap RF MEMS varactors
Authors: McFeetors Greg , Okoniewski Michal
Published: April 2024

The design, fabrication and measurement of a continuously tunable RF MEMS capacitor is described. The capacitor’s dual gap height architecture allows for electrostatic tuning with low resistive loss and a large tuning range. A new dual tuning scheme is introduced for use with two voltage sources. This dual tuning, coupled with a stress-induced bridge, is used to reach further device tuning. Measurements indicate a continuously tunable capacitance range of 6.2:1 with a quality factor over 50 at 30 GHz for 310 fF.
X-band coaxial monopole antenna with an additional metal screen
Authors: Khruslov Maksym , Pazynin Vadym
Published: April 2024

The novel coaxial monopole antenna design with an additional metal screen is presented. The radiation char- acteristics of this antenna are investigated depending on a dis- tance between the ground plane and additional metal screens, as well as on a size of the latter. Measured and calculated ra- diation patterns are compared within limits of the operative frequency band and their revealed distinctions are discussed. The antennas characteristics allow pronounce that it can be considered as a promising candidate for various practical ap- plications both a single radiator and a composite element of antenna arrays.
On the ambiguity function for accelerating target in FMCW radar
Authors: Rytel-Andrianik Rafał
Published: April 2024

In the paper, we are concerned with FMCWradar detection of an accelerating target, echo of which is buried in an additive white Gaussian noise. We derive and analyze three-dimensional generalized ambiguity function for target range, velocity and acceleration. We interpret known properties of this function and obtain new ones, which allows us to specify resolutions and regions of unambiguity for range, velocity and acceleration. The obtained resolutions we express in terms of corresponding Cramer-Rao bounds.
Interception of a free-rotating satellite: an autonomous rendezvous scenario
Authors: Seweryn Karol , Banaszkiewicz Marek
Published: April 2024

The spacecraft’s lifetime is often limited by reliability and redundancy of its components. Furthermore, serious restrictions on duration of spacecraft operations are posed by finite amount of fuel or cooling agent. It is also clear that once a satellite is launched, it is extremely difficult to replace/modify its hardware on the orbit. Future spacecraft missions, especially huge planetary orbiters, will require servicing support from autonomous unmanned satellites. In this paper we introduce and analyze a new scenario for interception of a free rotating satellite ion a Keplerian orbit. The scenario is divided into several stages to be executed by the servicing satellite: attitude determination of the target object; own motion planning; determination of the optimal target position and orientation before docking; controlled approach, i.e., decreasing of a range between satellites; orbiting of the servicing satellite around the target satellite; docking, i.e., radial degreasing of the intersatellite range till the satellites contact, while keeping constant the relative orienta- tion between them. The control algorithm for the servicing satellite motion during its maneuvers is described. Finally, a few examples of satellite motion simulations according to the proposed scenario are presented.
Feasibility study of the space synthetic aperture radar for the SSETI-ESMO project
Authors: Dawidowicz Bartosz , Kulpa Krzysztof
Published: April 2024

The following paper presents the analysis of the feasibility study of the SAR radar for lunar space missions. The European StudentsMoon Orbiter (ESMO) project is con- ducted by the Students Space Exploration and Technology Initiative (SSETI) association. The phase A of this project is supported by the European Space Agency (ESA).
Microwave radiometry in monitoring and emergency mapping of water seepage and dangerously high groundwaters
Authors: M. Shutko Anatoly , Haldin Alexander , Krapivin Vladimir , Novichikhin Evgenij , Sidorov Igor , Tishchenko Yurij , Haarbrink Roland , Georgiev Georgi , Kancheva Rumiana , Nikolov Hristo , Coleman Tommy , Archer Frank , Pampaloni Paolo , Paloscia Simonetta , Krissilov Anatoly , Camps Carmona Adriano
Published: April 2024

Detailed and geo-referenced maps identifying the locations of saturated and dry levees can be produced using microwave radiometric measurements from a light aircraft or helicopter, and integrated with GPS for positioning and orientation. The development of synergetic remote sensing technology for raised groundwater and seepage detection by the joint use of microwave and optical data along with GIS databases is an effective and most contemporary way of supporting risk assessment and facilitating disaster prevention and management. In this paper we present a remote sensing microwave technology for monitoring and detection of areas of water seepage through irrigation constructions, levees and dykes as well as for revealing areas with dangerously high groundwater level. The possibility for emergency response mapping, integrated with GPS and GIS data, facilitates the risk assessment and management services. The passive microwave radiometry (PMR) is based on spectral measurements in the millimetre to decimetre range of wavelengths. Compared to other remote sensing techniques, such as colour and infrared photography, thermal images and lidar, PMR is the only technology taking measurements under the earth’s surface and therefore is very well suited for water seepage and underground water monitoring in a fast and reliable way.
Modeling of mixed traffic for mobile cellular network
Authors: Islam Imdadu , Krishna Das Jugal , Hossain Siddique
Published: April 2024

The most convenient way of presenting one- or two-dimensional offered traffic in a network by Markovian chain to evaluate quality of service (QoS). Pictorial presentation of chain becomes very complicated for three dimensional traffic case, required for voice data integrated service/mixed traffic of mobile cellular network; hence application of cut or node equations become a cumbersome job. This paper proposes a model of three-dimensional traffic in a network for both unlimited and limited user case. Here direct analytical method is introduced instead of Markovian chain to achieve traffic parameters.