bluuebunny/crossref_metadata_2025 huggingface dataset:
ULUSLARARASI ANDLAŞMALAR HUKUKUNDA DEĞİŞİM, İSTİKRAR ve DEĞİŞİM YOLUYLA İSTİKRAR: REBUS SIC STANTIBUS
Authors: PİRİM Ceren Zeynep
Published: July 2022

Uluslararası andlaşmaların taraflar nezdinde bağlayıcı olduğunu ve iyi niyetle ifa edilmeleri gerektiğini ifade eden pacta sunt servanda ilkesinin temel amacı, her devletin zamanında ortaya koyduğu iradenin arkasında durmasını sağlayarak devletlerarası ilişkilerde ve uluslararası hukuk düzeninde istikrarı sağlamak ve korumaktır. Bununla birlikte, bir andlaşmanın yapıldığı dönemdeki koşulların önemli ölçüde değişmesi halinde andlaşmanın tarafları arasındaki denge bozulabilecek, andlaşmanın konu ve amacı anlamsızlaşabilecek ve hatta ortadan kalkabilecektir. Bu çerçevede, pacta sunt servanda ilkesini hiçbir koşulda istisnası olmayan bir ilke olarak yorumlamak, uluslararası andlaşmalardan doğan yükümlülüklerinden çok farklı konjonktür ve koşullarda bile kurtulamayacağını düşünen devletleri ahdî ilişkiler içine girmemeye sevk edebilecek ve uluslararası ilişkilerde istikrarsızlığa yol açabilecektir. İşte ahdî uluslararası hukukta istikrar ve değişim arasındaki denge, andlaşmaların, akdedilmelerine zemin hazırlayan koşullardan bağımsız düşünülemeyeceği anlayışı üzerine kurulu olan ve geleneksel olarak rebus sic stantibus olarak adlandırılan “koşullarda esaslı değişiklik” ilkesi aracılığıyla sağlanmaya çalışılmaktadır. İlke, uluslararası andlaşmaların, yapıldıkları dönemdeki koşullarda taraflarca öngörülemeyen esaslı değişiklikler yaşanması durumunda sona erdirilebileceklerini veya tarafların bu andlaşmalardan çekilebileceklerini öngörmektedir. Uluslararası andlaşmalar hukukunun yerleşik ilkelerinden biri olan rebus sic stantibus, bu alanın aynı zamanda en tartışmalı ilkelerinden biridir. Gerek ulusal gerek uluslararası yargı mercileri ilkeyi uygulamakta çoğu zaman tereddüt etmekte ve pozitif uluslararası hukukun bir parçası olduğu artık tartışma götürmüyorsa da ilkenin tam olarak ne anlama geldiğine ilişkin devletler arasında görüş ayrılıkları bulunmaktadır. 1969 Viyana Andlaşmalar Hukuku Sözleşmesi’nin 62. maddesi ve uluslararası içtihat ilkenin “uluslararası andlaşmaların taraflarının ortak beklentileri” temelinde uygulanması yönünde objektif bir anlayış benimsemekte, devlet uygulamaları ise “devletlerin yaşamsal menfaatleri” temelinde sübjektif bir yorumu kabul etmiş görünmektedir. Elinizdeki çalışma, rebus sic stantibus ilkesinin, bir yandan amacına hizmet edebilmesi, diğer yandan devletler tarafından keyfî bir biçimde kullanılmasının önüne geçilebilmesi için nasıl bir muhakeme yürütülerek ileri sürülmesi gerektiğini tartışmaktadır.
YARGITAY’IN GÜNCEL İÇTİHATLARI IŞIĞINDA MUHDESAT
Authors: AKÇAAL Mehmet
Published: July 2022

Muhdesat, taşınmaz üzerinde kalıcı olmak üzere bulunan yapı veya bitkilerdir. Bu sebeple, muhdesat hukukî niteliği itibarıyla bütünleyici parçadır. Bu niteliğin kazanılmasıyla birlikte muhdesat üzerinde önceki malzeme veya bitki sahibinin artık bir mülkiyet hakkından söz edilemez; taşınmaz üzerindeki aynî hak muhdesatı da kapsar. Bununla birlikte, muhdesattan dolayı hem hak sahibi hem de taşınmaz maliki birtakım istemlerde bulunabilir. Meselâ, muhdesat üzerinde alacak hakkına sahip olan taraf bunun tespiti veya sebepsiz zenginleşmenin iadesi amacıyla dava açabilir. Aynı şekilde, taşınmaz maliki de özellikle haksız yapıya ilişkin hükümler çerçevesinde tazminat, yıkım (kal), mülkiyetin devri gibi bazı hakları ileri sürebilir. Bu itibarla, muhdesat uygulamada sıkça karşılaşılan bir hukukî müessesedir. Dolayısıyla, uyuşmazlıkların zenginliği ve çeşitliliği konunun tercih edilmesinde etkili olmuştur. Üstelik, Yargıtay’ın eleştiriye açık kararları da ayrıca değerlendirilmiştir. Bu kapsamda, önemli bir misal olarak Yüksek Mahkeme’nin muhdesatın tespiti davasının istisnaî olduğunu, ancak bazı hallerde açılabileceğini, aksi takdirde hukukî yarar şartının yokluğu sebebiyle reddinin gerektiğini kabul eden içtihadı isabetli değildir.
YARGITAY KARARLARI IŞIĞINDA LİMİTED ŞİRKETTE ESAS SERMAYE PAYININ DEVRİ
Authors: TÜRE Murat
Published: July 2022

Bu çalışmada limited şirket esas sermaye payının devrinde öğreti görüşleri ve Yargıtay kararları incelenmiştir. 6102 sayılı Türk Ticaret Kanunu’nda limited şirket ile ilgili kapsamlı değişiklikler getirilmiştir. Limited şirkette gerçekleşen en önemli değişiklerden biri ise esas sermaye payının devrine ilişkin düzenlemelerdir. Limited şirkette esas sermaye payı bir malvarlığı değeri ve kanunen devredilebilen bir haktır. Esas sermaye payının geçiş hallerinden birisi de payın devridir. Limited şirket kurulduktan sonra aynı ortaklarla devam etmeyebilir. Bu durumda limited şirkette payın devri gerek ortaklar arasında gerekse üçüncü kişilerle TTK’daki hükümler çerçevesinde yapılmaktadır. Esas sermaye payının devri için, payın devri sözleşmesi yapılması, tarafların imzalarının noter tarafından onaylanması, pay devrinin şirkete bildirilmesi, genel kurul tarafından payın devrinin onaylanması, payın devrinin pay defterine kaydı, ticaret siciline tescil ve ilanı gerekir. Çalışmada esas sermaye payının devri esas alınmış, miras, eşler arasındaki mal rejimine ilişkin hükümler veya icra yoluyla esas sermaye payının geçmesi halleri ele alınmamıştır.
SEED PRIMING OF WHEAT THROUGH SALICYLIC ACID TO INDUCE SALT TOLERANCE
Authors: Idrees H , Shabbir I , Khurshid H , Khurshid A , Tahira RI , Fatima F , Younas A , Abbas HG
Published: July 2022

Wheat is an important cereal crop consumed throughout the world. Present study was planned to conduct in greenhouse of IMBB, University of the Lahore for determination of effects of salt stress on growth of wheat seedlings. Seed from selected wheat genotypes (SHAFAQ-2006, ANAJ-2017and Galaxy-2013) were used to grow in 54 pots, which were filled with 2kg pure washed sand. The sand was mixed with 500mg/kg of salt NaCl in each of the pot except of the control pots for wheat sowing. The seed of wheat variety were sown in triplicate pots with all irrigation requirements in equal manners. The use of salicylic acid (SA) for seed priming was more effective for number of roots per plant. The highest root length was recorded for treatment of SA priming + NaCl which indicated that the application of SA induced higher number of roots and long roots under salt stress conditions. The higher root water contents and shoot water contents were recorded under the application of water priming of seeds. The positive contribution of root water contents to root length indicated that the higher root water contents caused increase in shoot length due to higher water, mineral and nutrient absorption and retention which caused increase in photosynthetic rate and vice versa. It was found from results that the genotype GALAXY-2013 performed better under different treatments and SA priming application for root length, shoot length and number of roots per plant. The results suggested that the genotype GALAXY-2013 may be used to develop different wheat genotypes which may show higher grain yield under the applications of SA as seed priming compound while growing wheat in slat stress environment.
C33: Prise en charge du cancer de l’estomac en Afrique : Revue systématique et méta-analyse
Authors: Diallo A C , Ndong A , Thiam J I A T , Ba M B , Dieng P S , Somé R O , Diouf D , Dieng M M , Ka S , Dem A
Published: July 2022

INTRODUCTION : La prise en charge du cancer gastrique dans les pays à faible revenu peut être difficile. Notre objectif est de faire un état des lieux sur le cancer de l’estomac en Afrique. MATERIELS ET METHODES : Des études de cohorte, des études cas-témoins, des études transversales et des séries de cas ont été identifiées via les recherches EMBASE, PubMed, Africa Index Medicus, Africa Journals Online et Web of Science du 1er Janvier 2000 au 31 Décembre 2020. Méta-analyse a été réalisée en utilisant la survie à cinq ans estimés à partir d'études après cinq ans de suivi. L'hétérogénéité a été quantifiée à l'aide de la statistique 12. RESULTATS : Quarante-deux articles ont été pris en compte pour la revue systématique et huit pour la méta-analyse. La population totale était de 5.796 patients. Soixante-deux pour cent des patients étaient des hommes. L'âge moyen des patients était de 55,1 ± 4,34 ans. L'adénocarcinome était le type histologique le plus fréquent. La localisation antrale était la plus fréquente. Le stade IV représentait 1.199 patients (54,17%) et le stade III était de 21,8%. La chirurgie était généralement le premier traitement reçu par les patients (92%). La chimiothérapie néoadjuvante a été utilisée dans quelques cas (11,12%), il en était de même pour la radiothérapie (4,1%). Les complications post-opératoires et la mortalité étaient élevées. Dans certaines études, les complications chirurgicales atteignaient plus de 30 et 40% pour la mortalité. Le taux de survie globale était de 11,74%. Cependant, une hétérogénéité significative a été détectée (I2=82,67%). CONCLUSION : Notre étude a fourni un aperçu de l'épidémiologie du cancer de l'estomac et de sa gestion en Afrique.
UJI DAYA HAMBAT INFUSA AKAR KAIK KAIK (Uncaria cordata (Lour.) Merr.) TERHADAP PERTUMBUHAN BAKTERI Staphylococcus aureus
Authors: - Desi , Ngazizah Febri Nur , Romaidha Iqlila
Published: July 2022

Salah satu jenis tumbuhan yang sering digunakan sebagai obat di Kalimantan tengah khususnya suku dayak adalah Akar Kaik Kaik (Uncaria cordata (Lour) Merr). Tumbuhan ini mempunyai senyawa aktif yang terkandung antara lain polifenol seperti terpenoid, steroid, tannin, alkonoid, fenolik, saponin, yang dapat berpotensi sebagai anti bakteri. Salah satu bakteri yang dapat menyebabkan penyakit adalah Staphylococcus aureus. Infeksi yang disebabkan oleh bakteri ini biasanya timbul dengan tanda-tanda khas yaitu peradangan, nekrosis, pembentukan abses, serta dapat menyebabkan berbagai macam infeksi seperti pada jerawat, bisul atau nanah. Penelitian ini bertujuan untuk mengetahui seberapa besar potensi yang dihasilkan oleh infusa U. cordata terhadap pertumbuhan bakteri S. aureus pada berbagai konsentrasi. Uji anti bakteri dilakukan dengan metode kertas cakram. Uji anti bakteri ditandai dengan terentuknya zona bening di sekitar kertas cakram yang disebut dengan zona hambat. Penelitian ini menggunakan 5 perlakuan konsentrasi yaitu 100%, 80%, 60%, 40%, 20%. Berdasarkan hasil uji One Way ANOVA, menunjukan adanya pengaruh infusa U. cordata terhadap S. aureus dengan nilai signifikan (α < 0.05). Diameter hambatan rata-rata 100% = 15.7 mm, 80% = 14 mm, 60% = 12 mm, 40% = 10 mm dan 20% = 9 mm. Konsentrasi 100% paling baik dalam bentuk zona hambat yaitu dengan diameter 15.7 mm.
Thyroid metastasis of bladder urothelial carcinoma: A very rare case
Authors: HASSANI Wissal , ALAMI ABDESLAM , FARHANE FATIM , ALAMI ZINEB , BOUHAFA TOURIA , HASSOUNI KHALID
Published: July 2022

Metastatic disease to the thyroid is a very uncommon situation. The cancers that usually metastasize to the thyroid include the breast, lung, colon and kidney. To our knowledge, metastasis from the bladder to the thyroid is exceedingly rare. Here, we report a case of a unique metastatic transitional cell carcinoma to the thyroid gland three years after total cystectomy.
Low Dose Combined Spinal Epidural Anesthesia in a Parturient with Permanent Pacemaker insertion for Elective Cesarean Section: A Case Report
Authors: Divya Dr , Dogra Dr , Y Dr
Published: July 2022

We would like to report a case of parturient with complete heart block on permanent pacemaker who underwent elective cesarean section under combined spinal epidural anesthesia uneventfully. Parturient with complete heart block may be completely asymptomatic but are at a increased risk of sudden cardiovascular collapse, especially during labour. Permanent pacemaker insertion also imposes certain problems during the surgery. Maintenance of heart rate and rhythm is of particular importance in these cases.
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A hybrid pretreatment strategy for delignification of Aloe vera processing waste and its effectiveness towards saccharification
Authors: Gunasekaran Rajeswari , Jacob Samuel
Published: July 2022

A copious amount of rigid Aloe vera leaf rind (AVLR) has been produced from the aloe gel processing industries are majorly disposed as wastes since it has no commercial value. The cell wall compositional analysis revealed that significant quantity of cellulose (46% ± 0.76, w/w) and hemicellulose (18.5% ± 0.24, w/w) which justifies as potent source for bioethanol production. However, high lignin content (13.95% ± 0.45, w/w) hinders depolymerization of polysaccharides into fermentable sugars and subsequent fermentation for ethanol production. In the present study, microwave-assisted alkali (MAA) pretreatment of AVLR biomass was carried out by varying the power level (160 W, 320 W and 480 W) which showed a maximum delignification (66.38%) at 320 W. Scanning Electron Microscope (SEM), Fourier-transform infrared spectroscopy (FTIR) and X-ray powder diffraction (XRD) based characterization were performed to study the extent of delignification in AVLR biomass. The Gas Chromatography-Mass Spectrometry (GC-MS) analysis was performed for the liquid hydrolysate obtained after MAA pretreatment at 320 W indicated that the hydrolysate contained more of oxidized phenolic hydrocarbons that can be potentially utilized for other value-added product synthesis. A comparison of saccharification efficiency was performed using two different cellulase producers namely Aspergillus niger and Aspergillus sp. A maximum saccharification of 68.5% ± 0.34 was achieved by Aspergillus sp., that was 2.8% higher on comparing with untreated AVLR biomass. This indicates the feasibility of MAA pretreatment for AVLR biomass in order to improve the accessibility of fermentable sugars available for ethanol production.
A morphologic and morphometric study of articular facets of Patella
Authors: Parmar Jigna , Doshi Bhavik , Gautam Rupal , Joshi Hemang
Published: July 2022

Background: The patella plays a major role in flexion and extension of the knee. The patella morphology can be a predisposing factor in patella instability. The congruency between the patella and femur affects the kinematics of the patellofemoral joint, contact mechanics of the patellar cartilage, and strain in the underlying bone, whereby higher stresses and strains potentially contribute to cartilage wear and anterior knee pain.

Aim and Objective: The present study was conducted to assess the morphology of facets of patella.

Materials and Methods: The present study was conducted to assess the morphology of facets of patella. Ninety-six patella of unknown sex from bone store of Department of Anatomy were included in the study. The patellar morphology and morphometry were investigated. Statistical analysis was performed using the SPSS (v 12.01) software package (SPSS Inc., Chicago, Illinois). Statistical significance was set at P < 0.05.

Results: In the present study; 96 patella of unknown sex from bone store of Department of Anatomy were included in the study. The mean size of the right lateral facet was 23.34 mm and left lateral facet patella was 23.06. P value was non-significant. The shape of lateral facet was concave in 93.9% in the left patella and 100% in the right patella. The shape of lateral facet was flat in 6.1% in the left patella and 0% in the right patella. The mean size of the right medial facet was 17.68 mm and left medial facet patella was 17.39 mm. P value was nonsignificant. The shape of medial facet was concave in 2% in the left patella and 10.6% in the right patella. The shape of medial facet was convex in 69.4% in the left patella and 61.7% in the right patella. The shape of medial facet was flat in 28.6% in the left patella and 27.6% in the right patella. P value was non-significant.

Conclusion: The present study concluded that the mean size of the right lateral facet was more left lateral facet patella. The shape of lateral facet was concave in 93.9% in the left patella and 100% in the right patella. The shape of lateral facet was flat in 6.1% in the left patella and 0% in the right patella. The mean size of right medial facet was more than left medial facet patella. The shape of medial facet was concave in 2% in the left patella and 10.6% in the right patella. The shape of medial facet was convex in 69.4% in the left patella and 61.7% in the right patella. The shape of medial facet was flat in 28.6% in the left patella and 27.6% in the right patella.
A study of serum magnesium levels in acute myocardial infarction and its association with clinical outcome
Authors: Singh Harpreet , Khosla Pulkit , Kaur Jasleen
Published: July 2022

Background: Cardiovascular disease is one of the leading causes of mortality, morbidity, and increased health-care cost. Magnesium has been implicated in the pathogenesis of acute myocardial infarction (AMI) and its complications. Magnesium ions are considered essential for the maintenance of functional integrity of myocardium. The serum magnesium concentration was found to have great significance in AMI. The present study was undertaken to evaluate the prognostic value of serum magnesium in AMI.

Aim and Objectives: The aim of the study was (1) to evaluate serum magnesium levels in patients of AMI on 1st and 7th day post-myocardial infarction and (2) to evaluate validity of serum magnesium as prognostic indicator of Ami.

Materials and Methods: This observational cross-sectional study was conducted in the Medicine Department, Guru Nanak Dev Hospital attached to Govt. Medical College, Amritsar. A total of 40 patients of AMI were enrolled in this study. Serum magnesium levels were done for all the patients and its correlation with clinical outcome was observed.

Results: On day 1, mean serum magnesium levels in patients with ST-segment elevation myocardial infarction were 1.638 ± 0.19 whereas mean serum magnesium levels in patients with Non-ST-segment elevation myocardial infarction were 2.315 ± 0.321. Mean serum magnesium levels in patients with arrhythmias were 1.73 ± 0.35 on day 1 and 2.14 ± 0.25 on day 7 (P < 0.05). Mean serum magnesium levels at day 1 in patients having mortality are 1.452 ± 0.078 as compared to 2.105 ± 0.399 in rest of surviving patients. It was inferred from this study that patients with AMI with low serum magnesium levels are more prone to develop complications such as arrhythmias and death as compared to patients of AMI with normal serum magnesium levels.

Conclusion: Magnesium is an underestimated cation and has been implicated in the pathogenesis of AMI and its complications. Patients of AMI with low serum magnesium levels are found to be more prone to develop arrhythmias as compared to those with normal serum magnesium levels. Hence, it can be concluded that measurement of serum magnesium level is of prognostic significance in AMI.
Cost-minimization analysis of drugs used for empirical treatment of urinary tract infection in a tertiary care hospital
Authors: Murthy Mangala , Ghumre Dipti , Joshi Pankaj , Murthy Bhaskar , Pore Shraddha , Burute Shreyas
Published: July 2022

Background: Urinary tract infections (UTIs) are one of the commonly encountered infections and a large number of drugs are indicated in UTI ranging from oral conventional drugs to most advanced injectable drugs. Cost-minimization analysis (CMA) is employed to project the least costly drug when two treatments are shown to be therapeutic equivalents.

Aims and Objectives: This study aims to perform a CMA at a tertiary care center to determine the least expensive drug for UTI and to project a cheapest alternative from available options based on the results of CMA.

Materials and Methods: This was a cross-sectional study conducted over duration of 3 months in the clinical departments on patients diagnosed to have UTI and prescribed empirical antimicrobial treatment. The approval of Institutional Ethics Committee was sought before beginning the study. Pattern of drug prescription and average cost incurred in the treatment of patients with empirical antimicrobial therapy was calculated. CMA included the projection of the least expensive drug based on average cost incurred per patient in outpatients and inpatients respectively.

Results: A total of 59 patients of UTI given empirical treatment were included in the study. Fluoroquinolones and cephalosporins were commonly used drugs for empirical treatment of UTI. Nitrofurantoin (average cost of 11–14 Rs. per patient) can be projected as the cheapest drug for empirical treatment of UTI on outpatient basis as well as a drug to supplement injectables in indoor patients. Injectable ciprofloxacin can be projected as the most inexpensive alternative for empirical treatment of UTI in patients of the inpatient department.

Conclusion: Nitrofurantoin for oral treatment and ciprofloxacin in injectable form are cheapest among available alternatives for empirical treatment of UTI. To prevent treatment failures and increase in cost of treatment, correlation of results of CMA with local antimicrobial sensitivity pattern is important.
Covid-19 Pandemisi Sırasında Stratejik Yönetim Literatüründe Neler Söylendi?
Authors: BİLGİÇ Emre , AYDOĞAN Tahsin
Published: July 2022

Organizations are struggling with severe circumstances brought by COVID-19. When overly increased uncertainty and complexity in a pandemic are considered, strategic management has gained importance. Thus, researchers have focused on strategic management from different perspectives and this situation has led to that strategic management literature considering COVID-19 incredibly enlarged. Here, this research aims to show the architecture of the current literature and examine it with a holistic and critical perspective provided by using bibliometric analysis and critical systematic review concurrently. 226 articles were determined to represent the literature in two steps: (i) WOS search based on keywords and (ii) eliminating irrelevant articles by reading. To realize research aims, a twofold research method was adopted. By leveraging bibliometric analysis, the map of the current literature was shown. Then, a critical systematic review based on content analysis of 226 articles was carried out. Herein, more/less studied fields and future research directions were shared, and methods & levels of analysis of research were shared.
Moeten bindend adviseurs in consumentenkwesties ambtshalve toetsen op straffe van vernietigbaarheid van het bindend advies?
Authors: Hellegers D.P.C.M. , van Wechem T.H.M.
Published: July 2022

Moeten bindend adviseurs in consumentenkwesties ambtshalve toetsen op straffe van vernietigbaarheid van het bindend advies?

Wanneer partijen door middel van een bindend advies een geschil tot een oplossing wensen te brengen, dan maken zij daarmee jegens elkaar (impliciet) de belofte dat zij zich zullen houden aan de beslissing van de bindend adviseur. Wanneer één van de partijen zich echter niet conformeert aan de beslissing van de bindend adviseur, bijvoorbeeld omdat deze onwelgevallig uitpakt, dan kan de andere partij naar de burgerlijke rechter stappen om nakoming van de overeenkomst van (onzuiver) bindend advies te vorderen. In deze Ad Rem wordt hier nader op ingegaan.
Cancelcultuur en cancelclausules
Authors: Spanjaard J.H.M.
Published: July 2022

Cancelcultuur en cancelclausules

In het jaar 2022 haalden diverse schandalen de media, gevolgd door een oproep aan contractspartijen om de overeenkomst met een partij die betrokken was bij de schandalen te beëindigen. In deze bijdrage worden de mogelijkheden een contract in verband met schandalen te beëindigen, onderzocht en wordt stilgestaan bij op het onderwerp toegespitste contractsclausules.
Sois belle et tais-toi – blauwdruk van een NDA
Authors: Uijen M.
Published: July 2022

Sois belle et tais-toi – blauwdruk van een NDA

In deze bijdrage worden veelgebruikte standaardregelingen voor NDA's op een rij gezet en ontleed. De standaardregelingen kunnen eventueel als startpunt dienen voor de bepalingen die contractenmakers in hun eigen overeenkomsten zouden willen gebruiken; met een opsomming van aandachtspunten worden contractenmakers gewaarschuwd voor valkuilen die ze bij het opstellen van zulke bepalingen zouden kunnen tegenkomen.
Diseño de un producto hidratante con Aloe Vera e implementación de estrategias de marketing tradicional y digital
Authors: Grajales Mantilla Javier Leonardo , Mendez Chavez Vannya Esther , Figueroa Nathalia , Peña Sepulveda Angela Melissa
Published: July 2022

El cuidado de la piel es un hábito que cada días es mas relevante debido a la la exposición de las personas a los rayos solares y luces artificiales. Los rayos UV penetran las capas exteriores de la piel y pasan a las capas más profundas, dañando las células de la piel.

Vanaloe es un producto a base de Aloe Vera junto con otros componentes, el cual se centra en la hidratación de la piel, según estudios previos la preocupación por las afecciones de la piel vienen en aumento, de aquí nace la necesidad de la creación de un producto novedoso que consiste en un roll-on cuya finalidad es cuidar, hidratar y proteger la piel de las personas.

A través del proyecto también se identificó que solo crear el producto no es suficiente, sino que requiere de un proceso de mercadeo, que inicia por un mensaje de sensibilización y concientización a toda la comunidad en cuanto a lo que implica el cuidado de la piel, y dar a conocer cuáles son las consecuencias a las que se pueden enfrentar a largo plazo en caso de no tomar ninguna precaución.

Con la creación de Vanaloe se pretende disminuir y el envejecimiento prematuro de la piel, la aparición de manchas y lograr que cada vez sean menos las personas que están propensas a sufrir en el peor de los casos enfermedades como el cáncer de piel.

Con el lanzamiento de Vanaloe, las personas podrán tener un producto de buena calidad, con componentes naturales y a un precio accesible, Vanaloe le apunta a convertirse en el aliado número 1 para el cuidado de la piel, un producto que indudablemente todos deben tener.
In Situ Observations of the 21 April 2007 Tulia, Texas Tornado
Authors: Blair Scott F. , Deroche Derek R. , Pietrycha Albert E.
Published: July 2022

A localized tornado outbreak occurred across the Texas Panhandle during the afternoon and evening hours of 21 April 2007. One supercell thunderstorm produced an EF2 tornado in the town of Tulia, TX. A mobile mesonet vehicle was struck by the tornado while fortuitously collecting in situ data near the center of the vortex. The instrumentation sufficiently resolved the wind and pressure characteristics, at approximately 2.9 m and 2.6 m respectively above ground level, of the tornado’s micro-α scale environment. A maximum wind of 50.4 m s -1 and a pressure deficit of 194 hPa were measured, yielding the largest known pressure fall within a tornado. Analysis of the recorded data and instrumentation were conducted; results are presented and discussed.
Cellulitis Look-­Alikes
Authors: Petrak Russell
Published: July 2022

As Infectious Disease (ID) specialists, we are frequently confronted by a clinical scenario with a broad differential diagnosis. Bacterial cellulitis usually responds rapidly to appropriate antibiotic therapy, but when it does not, alternative diagnoses must be rapidly accessed and prioritized. To accomplish this, the ID specialist needs a functional understanding of cellulitis mimics. Utilizing the intensity of illness, appearance of the eruption, and the anatomical pattern of spread, the clinician can rapidly assess, identify, and treat the appropriate malady.
ПОНЯТТЯ ТА ОЦІНКА ІНВЕСТИЦІЙНОГО ПОТЕНЦІАЛУ ДОМОГОСПОДАРСТВ
Authors: Сидорчук Анатолій , Кириленко Ольга
Published: July 2022

Метою статті є дослідження інвестиційного потенціалу домогосподарств. З’ясовано, що наукові праці з зазначеної проблематики в переважній більшості розкривають поняття інвестиційного потенціалу через призму можливої участі домогосподарств власними заощадженнями у фінансовому ринку країни. Запропоновано формулювання інвестиційного потенціалу як обсягу готівкових ресурсів поза межами депозитних корпорацій, що можуть бути використані домогосподарствами для здійснення інвестицій – придбання ризикових фінансових інструментів (акцій, готівкової валюти, валютних депозитів, дорогоцінних металів) – і забезпечать у довгостроковій перспективі (понад 20 років) дохід, вищий за рівень інфляції. На відміну від існуючих підходів, це визначення відображає взаємозв’язок поняття з інвестиціями домогосподарств та очікуваним результатом. Для оцінки інвестиційного потенціалу запропоновано використовувати однойменний коефіцієнт , який визначається шляхом ділення обсягу грошового агрегату  (вимірює готівкові кошти поза межами депозитних корпорацій) на загальну величину доходів домогосподарства. Зазначено, що чим вищим є значення коефіцієнту , тим вищим є рівень інвестиційного потенціалу й тим більше можливостей для забезпечення фінансової стійкості домогосподарств у довгостроковій перспективі. Проведений аналіз показав, що, незважаючи на загальне зростання величини й доходів населення, і грошової маси в обігу поза межами депозитних корпорацій, інвестиційний потенціал вітчизняних домогосподарств за період 2012-2020 рр. не покращився. Отож, розраховане нами значення коефіцієнта інвестиційного потенціалу  у 2020 р. майже рівнозначне показникові 2012 р. Низький рівень фінансової грамотності та психологічні фактори виокремлюємо як основні причини, які впливають на стан інвестиційного потенціалу домогосподарств та на перспективи його реалізації на практиці.
Optimization of Samarinda City Parking Retribution Revenue Through e-Parking Innovation
Authors: Sipayung Baren
Published: July 2022

e-Parking is a parking service to realize safe, comfortable and transparent parking, which is expected to be able to launch progressive rates so that disputes between parking attendants and the community can be avoided. E-Parking is intended to reduce the practice of illegal parking attendants and retribution leakage can be overcome. The research method used is descriptive qualitative with interview, observation and documentation data collection techniques. To assess the effectiveness of E-Parking using Budiani's theory which includes the accuracy of program targets, program socialization, program objectives and monitoring. The results showed that the city government of Samarindah has succeeded in providing a tax service program to the government. There are also several program objectives that have been achieved because the accuracy of the target has been right where the target is the community, the Samarinda City Transportation Service and the Parking Interpreter. The monitoring of the program has been effective, followed by mentoring and evaluation of improvements that have been routinely carried out.
Missi di Era Disrupsi dan Pandemic
Authors: Markus Suwandi  , Sayang Tarigan
Published: July 2022

Jesus the Messiah, the Son of God was in His divine mission has prophesied His presence since the fall of the first man from sin. The person of Jesus has always been an interestings discussion and continued until the postmodern era when there was disruption and pandemics. Jesus Christ gave the disciples a missionary mandate to preach the Gospel. Observe the basics mission mandated by Jesus in John 20:21-22. But how is the Christian mission in the era of disruption and pandemics? This paper uses a descriptive methode approach with literature studies and exposition of reference texts as the database. God revealed His love in the mission of sending His Son into the world with a holy purpose to atone for sins. Likewise, Jesus sent disciples in every era encountered to preach the gospel. The Trinity divines God synergizes with the mission of the disciples. From this discussion, it is unequivocal that mission has a biblical basis in every era that existings.
PENGARUH KEAKTIFAN MAHASISWA DALAM ORGANISASI TERHADAP KECERDASAN SOSIAL PROGRAM STUDI MANAJEMEN PROFESIONAL MANAGEMENT COLLEGE INDONESIA
Authors: Siu Ong Cin
Published: July 2022

Kecerdasan sosial bermanfaat dalam menjalin hubungan sosial. Seseorang yang memiliki kecerdasan sosial yang baik mempunyai banyak teman, pandai berkomunikasi, dan mudah beradaptasi. Kecerdasan sosial ini dapat diasah dengan aktif dalam kegiatan organisasi. Perguruan tinggi Profesional Management College Indonesia menwajibkan mahasiswa untuk aktif berorganisasi dengan tujuan menjadikan mahasiswa yang mempunyai keseimbangan antara kecerdasan intelektual, kecerdasan emosional, kecerdasan sosial serta kecerdasan spiritual. Judul penelitian ini “Pengaruh Keaktifan Mahasiswa dalam Organisasi terhadap Kecerdasan Sosial Program Studi Manajemen PMCI” bertujuan untuk mengetahui seberapa besarnya Pengaruh Keaktifan Mahasiswa dalam Organisasi terhadap Kecerdasan Sosial.
Penelitian ini dengan pendekatan kuantitatif. Variabel dalam penelitian ini adalah keaktifan mahasiswa dalam organisasi dan kecerdasan sosial. Populasi dalam penelitian ini adalah mahasiswa Jurusan Manajemen PMCI sebanyak 131. Menggunakan tabel penentuan jumlah sampel yang dikembangkan Isaac dan Michael dengan tingkatan kesalahan 5% sehingga jumlah sampel ditentukan sebesar 95 orang dan diambil secara acak tanpa memperhatikan usia dan jenis kelamin. Teknik pengumpulan data dalam penelitian ini menggunakan angket. Analisis data dilakukan dengan analisis deskriptif dan korelasi product moment dengan bantuan program SPSS versi 25.0.
Hubungan kedua variabel dapat dilihat dari nilai koefisien Korelasi R=0,464. Nilai ini diinterpretasikan hubungan kedua variabel ada di kategori “Cukup Kuat”. Sedangkan nilai koefisien determinasi yang diperoleh adalah 21,6% yang dapat ditafsirkan bahwa keaktifan mahasiswa dalam organisasi (variabel bebas X) memiliki pengaruh kontribusi sebesar 21,6% terhadap kecerdasan sosial (variabel terikat Y) dan 78,4% lainnya dipengaruhi oleh faktor-faktor lain diluar variabel X.
Analisis Strategi Pengendalian Vektor Malaria di Kabupaten Bangka Barat
Authors: Asmiani  , Windusari Yuanita , Hasyim Hamzah
Published: July 2022

Kabupaten Bangka Barat merupakan satu-satunya kabupaten di Provinsi Kepulauan Bangka Belitung yang belum mencapai eliminasi malaria. Hal ini disebabkan karena masih ditemukan kasus malaria indigenous di Kabupaten Bangka Barat. Data pelaporan E-SISMALpada tahun 2020 di Kabupaten Bangka Barat menunjukkan bahwa kasus malaria indigenous berjumlah 8 kasus dan data pengendalian vektor malaria yang kosong atau tidak ada laporan. Penelitian ini bertujuan untuk menganalisis strategi pengendalian vektor malaria di Kabupaten Bangka Barat dalam rangka eliminasi malaria. Penelitian ini jenis penelitian kualitatif. Penelitian dilakukan di Kabupaten Bangka Barat pada bulan Mei sampai dengan Juni 2021. Penentuan informan penelitian dilakukan secara purposive. Pengumpulan data dilakukan melalui di focus group discussion, wawancara mendalam, observasi partisipatif dan photovoice. Validasi data yang digunakan berupa triangulasi metode dan sumber. Selanjutnya, dianalisis menggunakan aplikasi Nvivo 12 Plus for windows. Faktor-Faktor yang sering ditekankan oleh informan dalam penelitian sebanyak 8 Faktor. Faktor perilaku penambang (26 references), topografi wilayah (14 references), adaya pertemuan lintas sektor (6 references), dukungan lintas sektor, lintas program (5 references), kerjasama TNI/polri (5 references), keterbatasan SDM entomologi dan epidemiologi (18 references), keterbatasan dana (20 references) dan terbatasnya perlengkapan IRS (13 references). Penelitian ini menyimpulkan bahwa pelaksanaan strategi pengendalian vektor malaria di Kabupaten Bangka Tengah belum maksimal. Hal ini disebabkan beberapa faktor yaitu topografi wilayah, perilaku penambang, pertemuan lintas sektor yang belum berdampak langsung pada program malaria, advokasi kepada TNI dan Polri, keterbatasan SDM entomology dan epidemiologi, dana dan perlengkapan IRS.
Aproximación a la pintura mural en Caesarobriga (Talavera de la Reina, Toledo); la domus de la calle Lechuga, 1
Authors: De la Llave Muñoz Sergio , Pacheco Jiménez César , Romero López Lourdes
Published: July 2022

Se presenta un análisis preliminar sobre las pinturas murales documentadas en el solar de la calle Lechuga, 1 de Talavera de la Reina (Toledo). Durante las campañas efectuades entre los años 2004 y 2005, se descubrieron varias estancias asociadas a una domus que albergaban restos de decoración pictórica parietal datada entre mediados del siglo I y II d.C. Dado que no existe información publicada sobre pintura mural en Caesarobriga, se ha realizado un estudio que ha permitido conocer algunos aspectos técnicos, formales y compositivos que suponen un primer estado para aproximarnos a la antigua urbe lusitana que nos ocupa.
BIODIVERSIDAD DE Trichoderma SPP. EN MÉXICO Y SU POTENCIAL DE UTILIZACIÓN EN LA AGRICULTURA
Authors: Allende-Molar Raúl , Báez-Parra Karla Marina , Salazar-Villa Edith , Rojo-Báez Indira
Published: July 2022

Background. Trichoderma is a cosmopolitan genus of fungi with beneficial species that help both to improve the plant rhizosphere and combat pathogens in economically important crops. Due to its importance in the agricultural biotechnological field, the morphological and molecular identification of Trichoderma species is of interest; however, currently the information on identification, biocontrol and its applications in agriculture is scattered. Objective. The objective of this review was to carry out an exhaustive analysis on the identification of Trichoderma, as well as an analysis of biocontrol studies and applications of Trichoderma in agriculture in Mexico. Methodology. A bibliographic review of Trichoderma was carried out in the following databases: Scopus, Science Direct, NCBI, Google Scholar, Pubmed and USDA. The keywords used were Trichoderma, identification, morphology, molecular, antagonism, biocontrol, agricultural use, agricultural importance, and Mexico. The collection of information on Trichoderma species in Mexico was considered during the period from 2005 to 2022. Results. In Mexico, 42 species reported to date of Trichoderma based on morphological characteristics were found, the main identified species are T. harzianum, T. asperellum and T. viride; according to the ITS barcoding marker and tef1α gene region, 17 species reported to date have been identified at the molecular level. The main species reported are T. asperellum and T. harzianum. Additionally, the most reported species as antagonists are T. asperellum and T. harzianum, the latter being the one that is mostly marketed in biological products. Implications. Currently the species T. asperellum and T. harzianum stand out in identification, biocontrol, and application in agriculture. Conclusions. Morphological identification alone is difficult; recently in Mexico, the identification of Trichoderma species is carried out at an exhaustive level, complementing the morphological identification with molecular identification. At present, reports on the diversity of Trichoderma species have increased in identification, biocontrol, and applications in the agricultural area.
Multilingualism in Switzerland: An Overview
Authors: Dr. Muhammad Issa  , Mr. Muhammad Kamal  , Mr. Ansar Ali
Published: July 2022

Multilingualism claims centrality in the discourse community. Besides being an important aspect of linguistics, it has been a socio-political phenomenon. Developments in human history, particularly the growing concept of globalization, wars, treaties, invasions, colonialization, and migrations have ensured that most of the states in today’s world are multilingual, multicultural, or sometimes even multinational in character. During the 18th and the 19th centuries, the rising wave of nation-states based on one language, one culture, and one religion, multilingualism was considered and treated as a curse and menace to the socio-political harmony of the state. Nonetheless, there were few states which showed firm faith in unity in diversity. They remained neutral to those developments and kept alive through preserving, protecting, and flourishing the feature of multilingualism in state policies. Switzerland is considered the spearhead and torchbearer in this march. The foundation of modern Switzerland was established in 1848 by the federal constitution declaring the state multilingual. Even before that, it was a multilingual state comprising French, German, Italian, and Romansch. Today, all the four major languages of the country enjoy the prestige of the national language with a qualified promise to provide equal opportunities for other minor languages. In this context, this present paper offers an overview of the emergence, evolution, and sustainability of multilingualism in Switzerland. The main argument is that “quardilingualism” and multilingualism in Switzerland are not merely due to the state policies but mainly because of the people’s will to live in diversity and their mutual respect for individual idiosyncrasies.
The Impact of Viral Marketing and Destination Image on Visiting Intentions to Semarang City During The Covid-19 Pandemic
Authors: Firdaus  , Rusmiyatun  , Jatmiko Muhamad Roby
Published: July 2022

This study aims to explain the relationship between viral marketing and destination image variables on the intention to visit the city of Semarang. The sample in this study was 100 respondents. In comparison, the implementation of sampling in this study uses an accidental sampling technique, namely the technique of taking samples by chance from the respondents. The data analysis technique used multiple regression. The results of statistical tests concluded that (1) there is a positive and significant relationship between viral marketing and the intention to visit, which means that the higher the viral marketing in a city, the higher the intention to visit, and the second result (2) there is a correlation which is positive and significant between destination image and intention to visit, meaning that the better the destination image, the higher the intention to visit made by consumers to visit the city of Semarang. Conversely, the worse the viral marketing and destination image of consumers, the lower the intention to visit made by consumers. Findings : This research proves that with viral content and a good image of a tourist destination, it can make tourists interested in visiting the city of Semarang.
The use of online social network sites during the COVID-19 pandemic as a protective or risk factor for well-being of university students
Authors: Ögel-Balaban Hale
Published: July 2022

During the COVID-19 period, the use of social network sites (SNSs) has been reported to increase. The present study aimed to explore whether, on balance, their use serves the well-being of university students positively as a source of social capital and entertainment, or negatively as a source of information about the COVID-19 pandemic. It focused on a sample of 339 university students, a group which is known to have a high risk of well-being problems. Students completed the demographic information form, the use of SNSs form, and the World Health Organization Well-Being Index. The use of SNSs form included items on SNS use in terms of daily duration, usage patterns (active and passive use) and reasons with regard to social capital (bridging and bonding social capital) and entertainment, and the perceived change in these quantitative and qualitative aspects of SNS use compared to the pre-COVID period. It also measured the level of exposure to COVID-19 related information on SNSs. It was found that the increase in the duration of SNS use predicted the well-being score negatively whereas the increase in active use and use for bonding social capital related reasons predicted it positively. These findings suggest that the quantity and the quality of SNS use are differently related to the well-being of university students. The active use of SNSs, particularly for the purpose of connecting with the close networks might constitute protective factors for student well-being in the case of health emergencies like the COVID-19 pandemic.
“You want to know that you’re safe”: Experiences of risk, restriction and resilience online among people with an intellectual disability
Authors: Chadwick Darren David
Published: July 2022

People with intellectual and developmental disabilities remain more digital excluded than many other groups within society. Perceived vulnerability of people with intellectual and developmental disabilities by those providing support may increase their digital exclusion and the digital divide. Few studies have considered online risk from the perspective of adults with intellectual and developmental disabilities. Online risks have previously been classified as contact, conduct and content but little is known about how adults with intellectual disabilities experience these specific risks. Underpinned by post-postivist and phenomenological epistemologies, perceptions and meanings of online risks for people with intellectual and developmental disabilities were gathered. Individual interviews were conducted with thirteen adults with intellectual and developmental disabilities who all identified themselves as self advocates. Interview discussions considered online risk experiences of being online and using social media. Data were audio recorded, transcribed verbatim and analysed using thematic analysis. Overarching themes of risk experiences, awareness and support to manage salient risks, and developing independence and resilience through online participation were identified. Accounts also identified concerns around online risks and carer gatekeeping as potential instrumental factors in digital exclusion, such exclusion was considered detrimental to wellbeing. Adults with intellectual disabilities with low support needs appeared more able to manage online risk than may be presupposed by a vulnerability-focused perspective. The importance of utilising language salient to the person when discussing risk was also highlighted. Experiential learning to better understand and manage salient online risks appears a way forward for both research and practice.
Gonorrheal urethritis and antibiotic resistance
Authors: Golušin Zoran
Published: July 2022

Urethritis is a clinical syndrome characterized by the appearance of mucopurulent or purulent urethral secretions, with or without dysuria, due to an increased number of polymorphonuclear leukocytes in the anterior urethra. Recommended therapy for uncomplicated gonorrhea of the urethra, cervix and rectum when antimicrobial susceptibility of gonococci has not been tested, is a combination of ceftrixasone 1 g intramuscularly in one dose, with azithromycin 2 g in one oral dose. Antimicrobial therapy and prevention measures are the basis of the fight against bacterial urethritis. This fight is disturbed by antimicrobial resistance, which results in unsuccessful therapy and the possibility of complications of urethritis. Resistance of Neisseria gonorrhoeae to antibiotics has been known for decades, and there is a danger that in the future certain strains of N. gonorrhoeae will be resistant to all available antimicrobials if there are no new antibiotics that will not develop resistance quickly or in the case of development of effective vaccines.
Should statin therapy be used in medication of elderly patients?
Authors: Despotović Nebojša
Published: July 2022

The vast majority of studies on the use of statins in the elderly population, relate to rosuvastatin, atorvastatin. In general, the elderly do not use the highest doses of statins, but moderate doses for the secondary and lower doses for the primary prevention of cardiovascular diseases. One of the reasons for this practice is receiving a larger number of drugs for already existing chronic diseases (polypharmacy, comorbidities) and fear of drug interactions. In the secondary prevention of cardiovascular diseases, the use of statins is mandatory, while in the primary prevention of cardiovascular diseases in the elderly population, lower doses of statins are recommended, primarily rosuvastatin and atorvastitin, as more effective drugs, with longer half-lives and fewer side effects. The principle of statin use in the elderly population would refer to the decision to start therapy and the type of statin, adapted to each patient individually, as well as the beginning with smaller doses that would gradually increase.