bluuebunny/crossref_metadata_2025 huggingface dataset:
Análise comparativa entre o diagnóstico clínico da hanseníase e os exames histopatológicos realizados segundo os critérios da classificação de Madrid e a de Ridley-Jopling
Authors: NEVES René Garrido , HAHN Myriam Dumas , BECHELLI Luiz Marino , MELCHIOR JR Enzo , PAGNANO Paulo Mucio Guimarães , HADDAD Nagib
Published: December 2023

Foi realizado um estudo histopatológico comparativo segundo os critérios das classificações de Ridley-Jopling (RJ) e do Congresso de Madrid (CM) em diferentes tipos clínicos e grupos de hanseníase. Foi encontrada concordância entre ambos os critérios no grupo Indeterminado e nas fases regressivas dos tipos Virchowiano (V), Tu-berculóide (T) e Tuberculóide Reacional (TR). Os TR clínicos foram confirmados pelo exame histopatológico em 81,2% dos casos de acordo com os critérios do CM, enquanto 46,2% foram considerados "Borderline" de acordo com os critérios de RJ. Dos 48 pacientes clinicamente V, 17 (35,4%) eram "Borderline" (BL-2, BL-1, e BB), mas praticamente todos eram também V do ponto de vista histopatológico de acordo com o CM. Conclui-se que não há conveniência prática no estabelecimento de subgrupos, baseados na histopatologia, que não concordem perfeitamente com os critérios clínicos. Os Autores destacam a importância do estudo dos plasmócitos nos infiltrados V; dos linfócitos nos granulomas e da maneira diferente de agressão das terminações nervosas, especialmente nos poios T e V. A coloração dos lipídios pelo Sudão III é útil para caracterizar perfeitamente o polo V, reconhecer as estruturas residuais V, separar os subgrupos BT, BB e BL, ajudar no diagnóstico precoce dos infiltrados V e na diferenciação da vacuolização citoplasmática por edema dos TR.
Talassemia e hanseniase
Authors: RAMALHO Antonio Sérgio , PINTO JÚNIOR Walter , MAGNA Luis Alberto , BEIGUELMAN Bernardo
Published: December 2023

A talassemia β foi investigada em 165 brasileiros descendentes não miscigenados de italianos, 80 dos quais eram doentes de hanseníase, da forma virchowiana, e 85 estudantes universitários (grupo controle). A freqüência da talassemia foi de 6,25% entre os hansenianos e de 5,88% entre os estudantes. Apesar da similaridade da distribuição geográfica tanto da hanseníase quanto do gene da talassemia p em algumas regiões do globo, sobretudo da Ásia, a freqüência de indivíduos com o estigma talassêmico observada nas amostras analisadas não apoia a hipótese de que a hanseníase possa ter contribuído para manter as altas freqüências desse alelo, por intermédio da seleção a favor dos talassêmicos heterozigotos.
Investigación, comunicación y desarrollo educativo en América Latina. Aportes de la educación de adultos al conocimiento y mejora de la educación
Authors: Gajardo J. L. Marcela
Published: December 2023

La introducción recuerda el papel de Pablo Latapí, el CEE y la RLEE para despertar el interés por la educación de adultos, en particular dirigida a personas de sectores populares, muchas de ellas analfabetas o de baja escolaridad. Un primer apartado identifica en América Latina ocho tendencias a partir del análisis de las metas para el desarrollo educativo establecidas sucesivamente en los foros de Jomtien y Dakar, el programa de Educación para Todos, los Objetivos del Milenio y los Objetivos de Desarrollo Sustentable. El segundo apartado introduce las tendencias del progreso educativo de la región, que se desarrollan en el tercer inciso con base en la mejor evidencia disponible, teniendo como referentes las metas del Marco de Acción de Dakar en cuanto a la educación de jóvenes y adultos, la Meta 3 sobre acceso al aprendizaje y preparación para la vida adulta, y la Meta 4 sobre alfabetización. Se reconocen avances en educación primaria; se subraya que el acceso a secundaria sigue siendo insuficiente y desigual; se señalan avances y límites en alfabetización y paridad de género, y en cuanto a equidad, calidad e inclusión. En las conclusiones se sintetizan tendencias regionales y desafíos nacionales.
Panaceum. O leczniczych walorach wina od starożytności po współczesność
Authors: Ząbek Maciej
Published: December 2023

The article is a short synthesis of the long history of wine used as a universal medicine from antiquity to the present day. The author, as a cultural anthropologist, does not focus on the problems and pathologies that are usually encountered in contemporary medical publications on alcohol. He shows the reasons why the dominant narratives about wine and other alcoholic beverages changed at the end of the 19th century, and expresses hope for the reconstruction of the proper proportions.
Los clivajes ideológicos en México y Argentina.
Authors: Hurtado Ramírez Alejandra
Published: December 2023

En este artículo se exponen las variaciones de las preferencias ideológicas entre los votantes de acuerdo con el nivel de educación dentro del contexto mexicano y argentino en las elecciones presidenciales de 2018 y 2019. En este sentido, el objetivo de la investigación consiste en caracterizar ideológicamente a los votantes mexicanos y argentinos con educación superior a partir de las posiciones ideológicas que ocupan las principales fuerzas partidarias de ambos países. La metodología utilizada se sustenta en un análisis histórico para construir las narrativas analíticas sobre los orígenes de los principales partidos políticos en México y Argentina identificando, con base en la revisión de la literatura existente sobre el tema y en perspectiva comparada, los clivajes ideológicos en ambos países.
The Impact Of Parental Involvement And Self-Efficacy In Anchoring The Psychological Resilience Among Chinese Adolescents With Learning Difficulties: Mediating Role Of Achievement Motivation
Authors: Tianyu Zhao , Masnan Abdul Halim
Published: December 2023

Over the past few decades, there has been a noticeable focus on adolescents' learning and participation activities. Surveys and studies conducted in academic schools in China have reported an increase in cases of adolescents experiencing learning difficulties. The previouis research has linked the concept of learning difficulties and disabilities within the broader cultural, social, and academic context. Existing studies shed light on various factors responsible for triggering learning difficulties and how to resolve them. The literature commonly identifies academic factors, such as the school environment and teaching styles, as potential causes of learning difficulties. However, studies have often neglected social elements, including the role of parents and an individual's self-efficacy. This study examines personal and social factors to analyze their impact on the psychological resilience of adolescents. A quantitative design was adopted where data was collected from adolescents across China through Wen Juan Xing. The findings imply that parental involvement, but not self-efficacy, significantly impacts psychological resilience. Additionally, it was discovered that parental involvement, self-efficacy, and psychological resilience weren’t mediated by achievement motivation. The findings from the study can be used by parents, managers, and other children welfare organizations to develop policies and processes that are supportive of the development and resilience of the adolescents.
Adverse consequences Following COVID-19 Vaccination
Authors: Zayer Raheem Hussein
Published: December 2023

Background: Employing a potent preventive measure stands as the sole recourse against  COVID-19. The global scale of the COVID-19 pandemic has propelled an unparalleled rush  in vaccine development. This pressing demand has spawned a diverse range of approaches in  vaccine development considerations. Any potential adverse events from the COVID-19  vaccine are typical indicators that the body is building protection. Objectives: To identify the  prevalence, types and to investigate the possible attributed factors for the adverse events  associated with COVID-19 vaccines. Method: A descriptive cross-sectional study that was  conducted in the Iraq / Baghdad / Al-Resafa Directorate of Health (DOH) from the 7th of April  to the 5th of August 2021. A total of 420 participants were enrolled in the study. Results: The  most prevalent adverse events were injection site tenderness and joint pain /lethargy. There  was a significant association between the adverse event, time of disappearance, and the type of  vaccine, the highest percentage was associated with Pfizer BioNTech. The adverse events were  significantly higher in females. There was a significant association between the first and second  doses regarding the prevalence of injection site tenderness, joint pain, fever, and other adverse  events. Conclusion: Most vaccinated people developed mild adverse events, pain at the site of injection was the most prevalent adverse event. The gender and type of vaccine significantly  affected the development of the adverse events.
Grid Connected Wind Energy System Power Quality Improvement Using STATCOM
Authors: Divya Soni  , Upendra singh Tomar  , Narottam Dutt Upadhyay
Published: December 2023

The wind energy generation, utilization and its grid penetration in electrical grid are increasing worldwide. Injection of the wind power into an electric grid affects the power quality. The wind generated power is always fluctuating due to its time varying nature and causing stability problems. This weak interconnection of wind generating source in the electrical network affects the power quality and reliability. This paper demonstrates the power quality problem due to installation of wind turbine with the grid. In this proposed scheme Static Compensator (STATCOM) is connected at a point of common coupling with a battery energy storage system to mitigate the power quality issues. The STATCOM gives reactive power support to wind generator and also load. The battery energy storage is integrated to sustain the real power source under fluctuating wind power. The STATCOM control scheme is simulated using MATLAB/SIMULINK in power system block set.
Attendance Management System using Face Recognition
Authors: Gaurav Khadilkar  , Himanshu Sharma  , Pratik Khairwar  , Piyush Raipure  , Prof. Minakshi Getkar
Published: December 2023

The main purpose of this project is to build a face recognition-based attendance monitoring system for educational institution to enhance and upgrade the current attendance system into more efficient and effective as compared to before. The current old system has a lot of ambiguity that caused inaccurate and inefficient of attendance taking. Many problems arise when the authority is unable to enforce the regulation that exist in the old system. The technology working behind will be the face recognition system. The human face is one of the natural traits that can uniquely identify an individual. Therefore, it is used to trace identity as the possibilities for a face to deviate or being duplicated is low. In this project, face databases will be created to pump data into the recognizer algorithm. Then, during the attendance taking session, faces will be compared against the database to seek for identity. When an individual is identified, its attendance will be taken down automatically saving necessary information into a excel sheet. At the end of the day, the excel sheet containing attendance information regarding all individuals are mailed to the respective faculty.
Roadside Assistance Finder
Authors: Saloni Meshram  , Chetan Meshram  , Diwyanshi Landge  , Swapnil Meshram  , Dr. Nitin Janwe  , Prof. Sachin Dhawas
Published: December 2023

A growing number of cars on the road are vulnerable to emergencies or breakdowns in today's fast-paced world, making roadside assistance timely and dependable. The goal of the Roadside Assistance Finder project is to create a clever and practical way to easily link drivers in need with local assistance services. The system makes use of cutting-edge technologies to improve service providers' and drivers' overall experiences. The suggested application facilitates the quick and simple search for mechanics. Locating mechanics in a nearby area is a challenging task when traveling. This system offers mechanics details with a single click, which helps to solve the problem
Influence of oral hormonal contraception on the concentration of anti-Müllerian and reproductive hormones in patients with polycystic ovary syndrome
Authors: Dumanić Klara , Marušić Jelena , Mudnić Ivana
Published: December 2023

Aim: To investigate the effects of three-month use of oral hormonal contraception (OHC) on hormonal status and ovarian reserve indicator (anti-Müllerian hormone, AMH) in patients with polycystic ovary syndrome (PCOS).Methods: 19 patients with diagnosed PCOS and clinical and laboratory signs of hyperandrogenism without additional comorbidities and co-medication were included in the study. All participants received therapy with the same oral hormonal contraceptive (fixed combination of 0.035 mg ethinyl estradiol and 2 mg cyproterone acetate). The main outcomes were the concentrations of reproductive hormones measured before starting therapy and in the first cycle following therapy. Hormone concentrations were analysed using the immunochemical electrochemiluminescence (ECLIA) method.Results: Initial concentrations of total and free testosterone and AMH were elevated, while initial concentrations of other reproductive hormones were within reference values. By applying the therapy, the concentrations of AMH, luteinizing hormone (LH) and estradiol decreased by more than 20% and those of free testosterone by 85%. The concentration of sex hormone binding globulin (SHBG) increased by 44%.Conclusions: Three months of oral hormonal contraception with 35 μg ethinyl estradiol and 2 mg cyproterone acetate reduced elevated concentrations of AMH and free testosterone in PCOS patients. The decrease in serum AMH concentration indicates a temporary interruption of folliculogenesis as well as the selection of follicles from preantral to antral, and the decrease in androgens has a positive effect on the clinical condition and symptoms of patients with PCOS.
SOCIO-ECONOMIC DETERMINANTS OF ARABLE CROP FARMERS’ ADAPTATION TO CLIMATE CHANGE IN EDO STATE, NIGERIA
Authors: J. Ahmadu  , S.U. Ewansiha
Published: December 2023

This study examined the socio-economic determinants of arable crop farmers’ adaptation to climate change in Edo State, Nigeria. Primary data for the study were collected using structured questionnaire administered to 192 respondents randomly sampled from the study area. Data analysis was done using descriptive statistics, multiple regression and information from Likerttype scale. Results of the study showed that the climate change adaptation practices highly employed by the farmers include mixed cropping, inter-cropping, adjusting the timing of land preparations in accordance with weather variations, adjusting the planting dates, crop rotation, application of inorganic fertilizer, processing of farm produce to reduce post-harvest losses, changing the quantity of fertilizer used and changing the quantity of herbicides/pesticides used. Extension contact and farm size of the farmers were found to be the significant (P<0.01) determinants of the farmers’ adaptation to climate change. Serious constraints faced by the farmers in adapting to climate change include inadequate finance, inadequate information on climate change, lack of support from government and other institutions, and inadequate infrastructural facilities. The farmers would employ more practices to adapt to climate change if they are empowered through education, training and provision of timely and accessible credit.
PREVALENCE OF HEAT-RESISTANT VIBRIO PARAHAEMOLYTICUS IN RETAIL SEAFOOD
Authors: Tiong Hung King , Walker AhKaylac , Wei Xiaoning , Meza Guadalupe
Published: December 2023

Previous work using a modified two-step enrichment method recovered total Vibrio parahaemolyticus, including the regular and heat/pasteurization-resistant strains. These strains would remain undetectable by exclusive cultivation protocol, attributed to their viable-but-nonculturable (VBNC) property, from environmental shellfish seafood. Hence, this suggests the need to validate retail seafood safety from this human pathogen and reform the inspection examination and cooking protocols mandated by the regulators to mitigate vibriosis recurrence. This modified method was further explored with raw, frozen shellfish seafood products from retail stores nationwide in the US for heat/pasteurization-resistant V. parahaemolyticus using nourishment only (one-step enrichment) or nourishment and heating selection (two-step enrichment) combined, followed by selective cultivation on thiosulphate-citrate-bile-salt agar (TCBS) media. Both presumptive regular and heat-resistant V. parahaemolyticus were recovered from processed shrimps (deveined/non-deveined, shell, and tail on), and non-processed oysters and crabs. Of 29 isolates recovered, nine (31%) were confirmed as heat-resistant (two from oyster; 7%) and regular (seven, two from shrimp; five from oyster; 24%) V. parahaemolyticus using 16S rDNA bacterial identification. However, none of them were resistant to pasteurization conditions. Virulence phenotype and genotype examinations indicated the presence of hemolysis- and urease-positive V. parahaemolyticus and that their unparallel phenotype/genotype correlation could be attributed to gene manipulation. For the first time, the present study reveals the prevalence of total V. parahaemolyticus, both regular and heat-resistant pathogenic strains, in retail shellfish products using the modified two-step enrichment technique and acclaims the need to reform the investigative and cooking standard protocol of USDA and other food safety regulatory entities.
MILK SECTOR TRENDS: THE CASE OF ALBANIA
Authors: BIÇOKU Ylli
Published: December 2023

Since the transformation of Albania's agricultural sector in 1992, it has shifted from subsistence farming to a thriving commercial industry, making a significant 17.7% contribution to the country's GDP. Among the agricultural subsectors, animal production, particularly in the dairy sector, plays a pivotal role in both farm income and market supply, contributing about 40% to the total agricultural value. Despite this positive trajectory, the dairy production sector is confronted with a set of challenges. This paper conducts a comprehensive analysis of the dairy sector in Albania, using a systematic methodological approach that involves primary and secondary data analysis. The analysis underscores the need for substantial improvements in various aspects of primary production. These improvements should primarily focus on feed and forage practices, specialized dairy breeds, and advanced animal husbandry techniques. Attention is also required for milking and milk collection, which includes maintaining high standards of hygiene, animal health control, milk safety, quality controls, and effective cooling systems. Furthermore, the conclusions highlight the significance of strengthening public extension services, motivating agricultural advisors, and providing financial support to address the knowledge gaps among farmers. Additionally, it is crucial to emphasize that Albania currently depends on net imports for various agricultural products, including milk, as it aligns with EU standards. This underscores the need for efforts to enhance competitiveness and food quality within the dairy sector. The findings of this study are based on the information and data accessible at the time of the analysis, and thus, they may not capture the entirety of the complexities within the dairy sector in Albania. The dairy industry is subject to various external factors, such as changes in global markets, trade policies, and economic conditions, which can influence its performance. In summary, while this research provides valuable insights into the challenges and prospects of Albania's dairy sector, readers should consider these limitations to understand the potential constraints and biases in the study, as well as the dynamic nature of the industry beyond the scope of this analysis.
Membership matters
Authors: Mensik Kennedy Jennifer
Published: December 2023

ANA’s strength comes from the participation of its diverse members.
VAI TRÒ CỦA CỘNG HƯỞNG TỪ KHUẾCH TÁN VÀ ĐỘNG HỌC BẮT THUỐC TRONG CHẨN ĐOÁN PHÂN BIỆT U BUỒNG TRỨNG LÀNH TÍNH VÀ ÁC TÍNH CÓ THÀNH PHẦN MÔ ĐẶC TẠI BỆNH VIỆN K
Authors: Ngô Đức Anh , Nguyễn Duy Thái , Hoàng Thị Vi Hương , Vũ Thúy Hằng , Đặng Phước Triều , Nguyễn Văn Thi
Published: December 2023

Mục tiêu: Nghiên cứu nhằm đánh giá giá trị của cộng hưởng từ (CHT) khuếch tán và động học bắt thuốc tương phản trong chẩn đoán phân biệt u buồng trứng lành tính và ác tính có thành phần mô đặc tại bệnh viện K. Đối tượng và phương pháp: Phân tích hình ảnh CHT 108 u buồng trứng có thành phần đặc trong khoảng thời gian từ tháng 01 năm 2022 đến tháng 08 năm 2023 tại bệnh viện K. Khảo sát các đặc điểm: tín hiệu mô đặc trên T2W, tín hiệu mô đặc trên DW, giá trị ADC, loại đường cong bắt thuốc; so sánh giữa các nhóm u lành và u ác. Kết quả: Tín hiệu mô đặc cao trên T2W, tín hiệu mô đặc cao trên DW, giá trị ADC < 1,166 x 10-3 mm2/s, đường cong bắt thuốc loại 2, 3 chẩn đoán u ác tính có độ nhạy và độ đặc hiệu lần lượt là 72,4%; 81,6%; 80,3%; 94,7% và 90,6%; 84,4%; 68,8%, 59,6%. Kết hợp CHT khuếch tán thêm vào CHT thường quy giúp tăng độ đặc hiệu lên đến 100% so với 90,6% khi chỉ dùng CHT thường quy, độ nhạy giảm từ 72,4% xuống còn 50%. Kết hợp động học bắt thuốc với CHT thường quy giúp tăng độ đặc hiệu từ 90,6% lên đến 96,9%, độ nhạy giảm từ 72,4% xuống còn 69,7%. Kết luận: CHT khuếch tán và động học bắt thuốc đều làm tăng độ đặc hiệu, giúp củng cố giá trị của CHT trong chẩn đoán phân biệt u buồng trứng lành tính và ác tính.
XÁC ĐỊNH MỘT SỐ DỊ NGUYÊN THƯỜNG GẶP TRÊN BỆNH NHÂN VIÊM MŨI DỊ ỨNG BẰNG PANEL TEST 60 DỊ NGUYÊN TẠI BỆNH VIỆN ĐẠI HỌC Y HÀ NỘI
Authors: Nguyễn Song Hào , Cao Minh Thành
Published: December 2023

Đặt vấn đề: Viêm mũi dị ứng (VMDƯ) là bệnh lý viêm niêm mạc mũi qua trung gian của kháng thể IgE khi tiếp xúc với dị nguyên từ môi trường qua đường mũi. Có rất nhiều dị nguyên, xác định được dị nguyên giúp người bệdị ứng tránh các dị nguyên đó, giúp hạn chế mắc bệnh. Panel test là test xét nghiệm (XN) 60 dị nguyên. XN sử dụng mẫu huyết thanh để xác định xem trong máu của người bệnh có tồn tại kháng thể IgE (Immunoglobulin E) đặc hiệu với dị nguyên hay không, từ đó xác định được các dị nguyên gây dị ứng đối với cơ thể và bệnh lý VMDƯ. Mục tiêu: Mô tả đặc điểm lâm sàng của bệnh nhân VMDƯ tại Bệnh viện Đại học Y Hà Nội năm 2022-2023, Đánh giá tỷ lệ các dị nguyên thường gặp trên nhóm bệnh nhân VMDƯ trên. Đối tượng và phương pháp: Phương pháp nghiên cứu là mô tả cắt ngang. Đối tượng gồm 92 bệnh nhân được chẩn đoán VMDƯ và được thực hiện xét nghiệm Panel test tại bệnh viện Đại học Y Hà Nội từ tháng 07/2022 đến 06/2023. Kết quả: tuổi trung bình 29,98, thời gian mắc bệnh trung bình là 4,79 năm. Các triệu chứng cơ năng ngứa mũi (82,6%), ngạt mũi (92,4%), hắt hơi (93,5%) và chảy nước mũi (81,5%). Các triệu chứng thực thể như niêm mạc nhợt (100%), cuốn mũi nề (93,5%) ở bệnh nhân nghiên cứu, còn polyp mũi chỉ gặp với tỷ lệ 18,5%. Các dị nguyên dương tính với tỷ lệ cao: IgE (100%), Bụi nhà (47,8%), D.pteronyssinus (53,3%), D.farinae (55,4%), Gián (34,8%), Tôm (29,3%), Nhộng tằm (25%).   Kết luận: Các dị nguyên gặp nhiều nhất gây VMDƯ trong 92 bệnh nhân nghiên cứu là bụi nhà, D.pteronyssinus, D.farinae, gián, tôm, nhộng tằm. Có 7,6% bệnh nhân dị ứng với 1 dị nguyên, 31,5% dị ứng với 2-4 dị nguyên, 28,3% dị ứng với ≥ 5 dị nguyên.
Relationship of Transforming Growth Factor-Βeta, C-Reactive Protein, and Lactate Dehydrogenase in Bronchial Washing with the Diagnosis of Non-Small Cell Carcinoma Lung Cancer
Authors: Vikaneswari Putu Kessi , Candrawati Ni Wayan , Kusumawardani Ida Ayu Jasminarti Dwi , Arisanti Ni Luh Putu Eka , Krisdanti I Desak Putu Agung , Aryanthana Gede Oky , Wadanta Pande Budi , Rai Ida Bagus Ngurah
Published: December 2023

Background: Most lung cancer cases are diagnosed at an advanced stage. Bronchial washing fluid contains many inflammatory cytokines that play a role in the malignant process. The aim of this study was to analyze the relationship between TGF-β, CRP and LDH in bronchial washing fluid with diagnosis of non-small cell lung carcinoma (NSCLC). Method: This research is an observational analytical study with a cross sectional design at Prof. Ngoerah Hospital, Denpasar (May 2023-August 2023). Descriptive analysis describes subject characteristics and research variables. Normality test with Shapiro Wilk. Bivariate analysis uses the unpaired T test with a normal distribution and the Mann-Whitney test with a non-normal distribution, data in the form of mean and standard deviation. Multivariate analysis with logistic regression. Results: The total research samples were 37 samples. 23 samples were detected as non-small cell lung carcinoma; 14 samples as non-NSCLC. The research results showed a significant relationship between TGF-β levels and diagnosis of non-small cell lung carcinoma (346.11 ± 40.21 pg/mL) vs (290.01 ± 66.22) (p < 0.05) and a significant relationship between LDH levels and diagnosis of non-small cell lung carcinoma (140.38 ± 98.11 U/L) vs (56.62 ± 22.68) (p < 0.05). There was no significant relationship between TGF-β, LDH, CRP and histopathology, bronchoscopy lesions and cancer stage of non-small cell lung carcinoma. Conclusion: There is a significant relationship between TGF-β and LDH levels and diagnosis of non-small cell lung carcinoma. TGF-β and LDH levels are increased in non-small cell lung carcinoma.
Platelet Indices and Intracoronary Thrombus Grade as Predictors of In-Hospital Major Cardiovascular Events in Patients with ST Elevation Myocardial Infarction Post Primary Percutaneous Coronary Intervention
Authors: Gunawan I Wayan , Artha I Made Junior Rina , Darma I Kadek Susila Surya
Published: December 2023

Background: The high mortality rate of ST Elevation Myocardial Infarction (STEMI) is caused by its complications, especially in-hospital major cardiovascular events (MACE). This study aims to determine the relationship between platelet indices and intracoronary thrombus grade as predictors of in-hospital MACE and the interaction of the combination of both predictors in patients with STEMI post-primary percutaneous coronary intervention (PCI). Methods: This prospective cohort study was conducted with STEMI patients who underwent primary PCI. Data was analyzed by SPSS 24.0.0.0 version. Results: There were 71 samples: 46 patients (64.8%) with a high platelet index and 48 patients (67.6%) with a high intracoronary thrombus grade. During in-hospital follow-up, there were found that 42 patients (59.2%) experienced MACE. The cut-off value used classifies high platelet index for PDW 11.25 fl (AUC 0.892; CI 95% 0.786-0.999; p<0.001) and MPV 10.15 (AUC 0.901; CI 95% 0.812-0.990; p<0.001). The Cox regression backward log-rank model showed both high platelet indices (adjusted HR 38.13; CI 95% 5.16-282.03; p<0.001) and high Intracoronary Thrombus Grade (adjusted HR 31.67; CI 95% 4.28-234.54; p=0.001) played an independent role as predictors of MACE during hospitalization, regardless of the influence of coronary angiography results, Killip class, smoking and consumption of acetosal and clopidogrel. The combination of two predictors of high platelet indices and high Intracoronary Thrombus Grade based on SEM analysis showed that 95.2% experienced in-hospital MACE (Mantel-Haenzel Common Estimate 17.48; Breslow-Day Homogeneity p=0.772; Cochran’s and Mantel-Haenszel p=<0.001), had better predictive ability as seen from the comparison of the respective AUC values, namely the combination, high platelet indices and high Intracoronary Thrombus Grade (0.942; 0.902; 0.873; p<0.001). Conclusion: High platelet indices and high intracoronary thrombus grade can be used as additional information for risk stratification of in-hospital MACE of STEMI patients post-primary PCI, especially when both variables were combined.
Investigation of Rainfall Influence on Characteristics of Particulate Matter 2.5 in Jakarta City
Authors: Ramadhina Shafiya Qonita
Published: December 2023

This study aims to investigate the impact of rainfall on the characteristics of particulate matter 2.5 in Jakarta city. The particulate matter 2.5 has an adverse impact on human life, while the precipitation reduces concentrations of pollutants in the environment, thus the scavenging effect of PM2.5 by precipitating must be investigated. It needs secondary data of PM 2.5 taken from the AirNow Department of State, meanwhile rainfall data has been extracted from the Meteorological, Climatological, and Geophysical Agency (BMKG). Some analyses have been conducted to understand the influence of rainfall impact on PM 2.5 presence in the atmosphere above Jakarta city. The windrose analysis is performed to know the amount of pollutants transported in one location. Then, the fluctuations in rainfall juxtaposing with the average PM 2.5 concentration to see PM 2.5 concentration while rainfall exists. Subsequently, the data correlations are analyzed using a correlation test based on the Spearman correlation method. As a result, the scarcity of rainfall results in elevated concentrations of PM 2.5, and most likely when higher rainfall, the lower PM 2.5 concentration. Moreover, there is a significant correlation between precipitation levels and PM 2.5 concentrations, as evidenced by the 2019 data, which exhibits an R-value of -0.52.
Solar Distillatory
Authors: Hernández Benito Armando Cervantes , Avendaño Javier Pérez , Lopez Alfredo Montes
Published: December 2023

The solar distillatory design is a project which born of the social point of view, keeping in mind that hundreds of water liters are wasted every year, this project is developed with the purpose of obtain distillated liquid for the chemistry lab and help the students with their activities in the Universidad Tecnológica de Tlaxcala. Therefore, the stages, in which the evaporation and condensation under the thermodynamics were performed, are described in general terms. The Sun makes it a removable source, playing a very important role in the system warming, the types of energy transference implicated such as radiation, convection and conduction were analyzed. The main components of a distillatory are covers and tray, they must be put through an energetic test during the design final stage. This calculation is also applied to the fluid, which is going to be analyze, the amount of heat that is absorbed and how much water is wasted throughout the project also. A system function analysis was conducted and with it and using variables like temperature, radiation, time, initial and final volume, compare the theoretic data with the real data obtained during the prototype function, this determines the efficiency of the mechanism and the amount of liquid coming out clean per day. The distilled water is composed by two hydrogen atoms and one oxygen atom, which molecule is represented chemically by the formula H2O. The liquid component has been put through a distillation process in which impurities and the origin water ions were eliminated.
Early Detection of Learning Disorders and Attention Deficit/Hyperactivity Disorder Among Children in Elementary School
Authors: Setiawati Yunias , Fithriyah Izzatul , Wahyurini Melati , Dianasari Dianasari , Hartopo Dhenni , Jessica Lia , Dala Andi Gita Fitri Martasiyah
Published: December 2023

Objective: Learning disorder is a problem that is often encountered in children in school, which can hinder their learning ability. Early detection of learning disorders involves observing the signs and symptoms of learning disorders in children, such as difficulty in reading, writing, counting, or memorizing information. In the early detection stage, the use of valid and reliable assessment tools can help identify children at risk of learning disorders. After early detection, the next step is appropriate management to help children overcome learning disorders. The management of children’s learning disorders in schools involves a multidisciplinary approach that involves cooperation between teachers, psychologists, parents, and medical personnel. Method: Screening of 126 elementary school students in Surabaya using the Colorado Learning Difficulties Questionnaire (CLDQ) to assess the presence of learning disorders. The Indonesian Hyperactivity Child Behaviour Assessment Scale (SPPAHI) is used to assess the presence of attention-deficit/hyperactivity disorder (ADHD) in Indonesian population. Results: Screening with CLDQ resulted 22 (17.5%) of 126 children required attention and referrals related to learning disorders in various aspects and 104 children (82.5%) within normal limits. Screening with SPPAHI showed 19 children (15.1%) had a high risk of ADHD and 107 children (84.9%) within normal limits. The study found 86.4% of children with learning disorders has a high risk of ADHD. Education of parents of children with learning disorders has been carried out as a follow-up to early detection. Conclusion: Early detection of learning disorders and parental education are useful in the management of learning disorders.
Heart Rate Response and Heart Rate Recovery After Harvard Step Test Between Young High Intensity Aerobic Athletes Smokers and Non-Smokers
Authors: Wisuda I Wayan Prasetya , Darma I Kadek Susila Surya , Yasmin AA Ayu Dwi Adelia
Published: December 2023

Background: Smoking has an influence on physiological responses and exercise performance. Exercise training results in a slow resting heart rate through changes in cardiac autonomic balance in addition to intrinsic remodeling of the sinoatrial node. Compared with athletes in static sports, heart rate is slower in athletes involved in dynamic sports. However, not many studies have examined how smoking affects the heart rate response and heart rate recovery in high-intensity aerobic athletes. Methods: This cross-sectional observational study. Data on age, gender, body mass index, smoker or non-smoker status, resting heart rate, and blood pressure before the test were collected. Maximum heart rate, heart rate 1 minute after maximum, heart rate recovery, and blood pressure after the test were measured. Data were analyzed using the SPSS version 24 program: unpaired t-test, Mann-Whitney test, ANCOVA. Results: A total of 50 samples were involved in the study, divided into 25 smoking athletes and 25 non-smoking athletes. The mean resting heart rate in smoking athletes was significantly higher (75 vs 66, p<0.001). The mean maximum heart rate was higher in smoking athletes but not statistically significant (149.5 vs 147.6, p=0.635). The mean 1-minute heart rate after the test was found to be significantly higher in smoking athletes (123 vs 112, p=0.018). The mean heart rate recovery was significantly lower in the smoking athletes (26.3 vs 35.2, p=0.002). Covariate analysis of age, gender, and body mass index did not have a simultaneous effect on resting heart rate, maximum heart rate, 1-minute heart rate after the test, and heart rate recovery (p>0.05). Conclusion: Resting heart rate and 1-minute heart rate after the Harvard Step Test were higher in young high-intensity aerobic athletes who were smokers. Heart rate recovery was lower in young high-intensity aerobic athletes who were smokers.
B-Lines Value on Lung Ultrasound and EVEREST Score Pre-Discharge as A Predictor of Rehospitalization and Total Mortality Post Hospitalization Due to Acute Heart Failure
Authors: Suadnyana da Bagus Surya Jaya , Wibhuti Ida Bagus Rangga , Wiryawan I Nyoman
Published: December 2023

Background: The high rate of rehospitalization in the vulnerable phase after treatment for acute heart failure (AHF) is caused by persistent hemodynamic congestion, even though the patient has experienced clinical improvement before being discharged. The B-lines value on Lung Ultrasound is a hemodynamic parameter that has the potential to determine the post-treatment prognosis of patients with AHF, while the EVEREST score is a marker of congestion which consists of several parameters used to assess congestion clinically. Methods: Patients treated for AHF with varying ejection fraction (EF) were included in this prospective cohort study. Data on demographics, comorbidities, pre-discharge therapy and pre-discharge echocardiographic parameters were collected. The pre-discharge B-lines value and EVEREST score were calculated a maximum of 24 hours before the patient was discharged. The outcomes studied were rehospitalization and total mortality within 60 days. Results: A total of 66 samples with various EF were included until the end of the study (15 HFpEF, 8 HFmrEF, and 43 HFrEF, mean age 57.14 ± 14.68 years). During the 60-day follow-up period, 19 samples (28.9%) experienced rehospitalization and total mortality. Both the B-lines value (AUC 0.716; 95%CI 0.581-0.851; p<0.006) and the EVEREST score (AUC 0.675; 95%CI 0.542-0.807%; p<0.027) served as predictors of rehospitalization and total mortality. The regression model showed that the pre-discharge B-lines score was ≥9 (adjusted HR 4.865; 95%CI 1.749-13.534; p=0.002) and the pre-discharge EVEREST score ≥2 (adjusted HR 3.694; 95%CI 1.211-11.262; p=0.022) played an independent role as a predictor of rehospitalization and total mortality, regardless of BMI, diabetes mellitus, renal impairment or TAPSE. Conclusion: The pre-discharge B-line value and EVEREST score can be applied to stratify the risk of rehospitalization and total mortality after treatment for patients with AHF.
Impact of Educational Intervention of Knowledge about Puberty in Indonesia’s Junior High School Students
Authors: Rochmah Nur , Faizi Muhammad , Hisbiyah Yuni , Perwitasari Rayi Kurnia , Pramesthi Calcarina Nira , Ardi Dinar , Fatwa Feelin
Published: December 2023

Purpose: The primary aim of this study was to determine the effectiveness of educational interventions in enhancing the knowledge of junior high school students in Indonesia regarding puberty and sexual organ health. Additionally, the study sought to support teenagers in understanding and coping with bodily changes. Design/methodology/approach: A non-randomized intervention study was conducted with 128 seventh-grade students at SMP Muhammadiyah 2 Taman, Sidoarjo. Seminars led by pediatricians educated participants about puberty. Knowledge was evaluated using pre-and post-tests, with data analyzed using SPSS. Findings: There was a general improvement in students’ understanding post-intervention, although the enhancement was modest. Specific topics, such as the definition of puberty and primary hormones causing puberty, witnessed significant advancements. However, some areas observed a decline in post-test scores. Research Limitations/Implications: The study’s primary limitation lies in its modest increase in knowledge post-intervention. For meaningful conclusions, a deeper analysis may be required, considering the diverse baseline knowledge levels among participants. The findings underscore the need for refined interventions to bridge the educational gap effectively. Practical implications: The research emphasizes the importance of early education on puberty and sexual health, highlighting the potential negative consequences of delaying such education. The study’s results could guide educators and policymakers in Indonesia to design and implement more effective puberty and sexual health educational programs. Originality/value: This study offers a unique insight into the challenges faced by Indonesian adolescents due to a lack of adequate education on puberty. It provides a novel approach to assessing the impact of educational seminars, serving as a blueprint for future interventions in similar contexts.
Comparative Study of Bioremediation Potential of Heavy Metal-Resistance Fungi Isolated from Mechanic Sites
Authors: Olatomiwa Shofoluwe-Ibikunle
Published: December 2023

Soil polluted with heavy metals (HM) have become common across the globe due to increase in geologic and anthropogenic activities. Mycoremediation is a widely accepted and an effective method of treating heavy metal polluted soils. In this study, the effect of heavy metals on HMR (heavy metal resistance) fungi and bioremediation potential of HMR fungi isolated from two different sites, and at three different soil depth of 0cm, 15cm and 30cm were compared. The soil samples were analyzed to determine the level of heavy metal contamination. Their resistance spectrum for the investigated elements was characterized by maximum tolerance concentrations (MTCs). The concentration of heavy metals used for MTC was determined based on the maximum concentration each fungal isolate could tolerate, the concentrations are 10mg/L – 15mg/L for Cu2+ and 4.0mg/L – 4.5m/L Zn2+ was quantified by atomic absorption spectrometry. On the basis of morphological characterization and biochemical analysis, the isolates belong to the genus Aspergillus spp., Penicillum spp., and Saccharomyes spp. Penicillium spp. has the least MTC for Zn2+ while Saccharomyces spp. showed the highest MTC for Cu2+. Studies on bioremediation potential of the HMR fungi isolates in the soil samples revealed mixed fugal culture completely removed zinc and copper from MG soil samples while in OPP soil samples the zinc and copper concentration have a reduction effect of 82.59%. Based on the fungal isolate Aspergillus spp. reduced copper in MG samples with a reduction effect of 88.98%. Penicillium spp. reduced zinc with a removal effect of 87.5% in MG samples, while Saccharomyces spp. has a zinc remediation effect of 96.48% and Penicillium spp. has a copper removal effect of 88.26% in OPP. The findings show that these fungi species have great bioremediation potential for highly contaminated Zn2+ and Cu2+ soils.
Immunological Effect of Goat Bile on The Immunity of Mice Infected with Plasmodium berghei
Authors: Arwati Heny , Aini Kholida Nur , Wardani Kartika Arum , Handajani Retno
Published: December 2023

Goat bile (GB) has been used traditionally as antimalarial medicine. Toxicity and antimalarial activity as well as the suppressive effect of GB have been reported previously. This study aimed to find out the immunological effect of GB on the serum level of IgG, TNF-α, and IL-10 in Plasmodium berghei ANKA. Fifty male BALB/c mice were infected with P. berghei ANKA and were divided into 5 groups. Groups 1-3 were treated with GB at a concentration of 25% (GB25), 50% (GB50), and 100% (GB100), respectively. Group 4 was a negative control and was given only sterile water. Group 5 was a positive control group, which was given 187.2 mg/kg body weight of the dihydroartemisinin-piperaquine antimalarial drug. Simultaneously, 3 groups of uninfected mice were treated with GB as above. Additionally, a group of normal mice without any treatment was used as a comparison control group. Treatments were given for four consecutive days. Parasitemia was observed daily on Giemsa-stained blood smears. Sera were collected on day five before the measurement of IgG anti P. berghei ANKA, TNF-α, and IL-10 levels by ELISA kit. Data were analyzed using one-way ANOVA, Mann Whitney, and Pearson correlation tests. Temporary mild diarrhea was seen in GB100-treated mice. All GB concentrations suppressed IgG production. The GB100 was more therapeutic, but GB50 and GB25 increased IL-10 levels as an antiinflammation response against infection. The pro-inflammatory effect of GB in normal mice caused TNF-α levels in GB-treated uninfected mice to be high. Both the toxicity and benefit of GB could be considered potential sources for the development of new anti-malarial candidates. The toxicity of GB should be considered seriously as the contradictive effect.
Relationship of Tumor Necrosis Factor Alpha, Monocyte-Lymphocyte Ratio, and Neutrophil-Lymphocyte Ratio of Bronchial Washing Fluid with Histopathology, Stage, and Bronchoscopic Lesions of Non-Small Cell Carcinoma Lung Cancer
Authors: Cassidy William Ray , Candrawati Ni Wayan , Kusumawardani Ida Ayu Jasminarti Dwi , Arisanti Ni Luh Putu Eka , Krisdanti I Desak Putu Agung , Sajinadiyasa I Gede Ketut , Rai Ida Bagus Ngurah
Published: December 2023

Background: Chronic inflammation has been shown to be closely associated with immunosuppressive conditions that support the microenvironment for tumorigenesis, tumor progression, and metastasis. The aim of this study was to assess the relationship of inflammatory cytokine levels TNF-a , neutrophil-lymphocyte ratio (NLR), monocyte-lymphocyte ratio (MLR) with histopathology, stage, and bronchoscopic features of non-small cell carcinoma lung cancer (NSCLC). Methods: This study was an analytical observational study with a cross-sectional design at the Prof. Dr. I.G.N.G Ngoerah Central General Hospital in January 2023 – September 2023. Data analysis was performed using the Mann-Whitney, Kruskal-Wallis and 2 independent sample t test. Results: There were 23 samples that met the inclusion criteria. The mean NLR, MLR, and TNF-a in this study were 8.939, 0.095, and 129.46 respectively. NLR was associated with KPKBSK histopathology (p = 0.026), KPKBSK stage (p = 0.003), tumour size classification (T) (p = 0.001) and metastasis (M) (p = 0009). MLR was associated with KPKBSK histopathology (p = 0.035). Smoking status had an influence on the relationship between MLR and KPKBSK histopathology (p = 0.032). TNF-a value was not associated with KPKBSK histopathology, bronchoscopic lesions, and stage. Smoking status had an influence on the bronchoscopic lesions of KPKBSK (p = 0.04). Conclusion: There are associations between MLR and NLR with histopathology of non-small cell carcinoma lung cancer. There is a relationship between NLR and the stage of non-small cell carcinoma lung cancer.
Data Centers and Green Energy: Paving the Way for a Sustainable Digital Future
Authors: Osibo Babasola , Adamo Simisola
Published: December 2023

As Information and Communication Technologies (ICTs) reach unprecedented heights of global influence, the USA stands as a leader with 91.8% of its residents connected to the internet. The interconnection of sectors like healthcare, finance, social media, and governance through the internet results in an immense volume of data, stored and managed globally within Data Centers. The surge in Data Centers in the USA, driven by a 4.12% CAGR and expanding service providers, prompts a critical examination of their environmental impact. Currently, nearly 2% of the USA's total energy production is attributed to Data Centers, predominantly reliant on conventional energy sources. This research explores the potential transition of Data Centers to green energy sources, investigating the feasibility of taking them off the grid. By aligning internet user growth, Data Center functionalities, and the USA's renewable energy capacity, the study aims to unravel the environmental implications and sustainability challenges faced by the Data Center industry. Through an in-depth analysis of key point indicators for Data Center sustainability and leveraging various renewable resources, the research assesses the viability of supporting Data Centers with green energy in the USA. The findings delve into predictions for renewable energy production, offering insights into aligning energy consumption patterns with sustainable practices for a greener digital future.