bluuebunny/crossref_metadata_2025 huggingface dataset:
Severe Fever and Thrombocytopenia Syndrome
Authors: Heo Sang Taek
Published: May 2022

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease, which is caused by thegenus Phlebovirus in the Bunyaviridae family. The syndrome was characterized by fever, gastrointestinal symptoms, neutropenia,and thrombocytopenia. Recent increase in the number of reported cases and deaths in endemic areas, such as China, Japan,and Korea, has posed the greatest public health concern. The first patient on Jeju Island where is the most endemic area inKorea was identified in May 2013. However, there is no currently effective treatment available for SFTS unresponsive tosupportive care. SFTS in terms of the development of therapies deserves further study.
Endoscopic Ultrasound Guided Drainage of Perihepatic Fluid Collection after Laparoscopic Pylorus Preserving Pancreaticoduodenectomy.
Authors: Choi Eun Kwang
Published: May 2022

27 year old woman visited ER due to severe epigastric pain who underwent laparoscopic pylorus preserving pancreaticoduodenectomy due to solid pseudopapillary tumor 3 years ago. CT scan showed loculated fluid collection in the perihepatic space. The fluid collection was punctured using a curvilinear echoendoscope followed by the placement of two 7-Fr double pigtail plastic stents across the liver. There were no early or delayed complications and the procedure was effective in relieving pain. Follow-up CT scan after 8 weeks showed completely resolved fluid collection. EUS guided drainage can be a feasible way to resolve the symptom in patient with fluid collection after pancreatic resection.
Submandibular Oncocytoma with Prominent Contrast Enhancement on Computed Tomography
Authors: Park Ji Kang , Kim Jeong Hong , Lim Gil Chai
Published: May 2022

An oncocytoma is a rare salivary gland neoplasm, and about 11% of oncocytomas of the salivary gland occur in the submandibular gland. This is a case report of an oncocytoma of the submandibular gland that showed strong homogenous contrast enhancement on a computed tomography (CT) scan. We summarize our case and review the imaging features of prior literature on oncocytomas. The submandibular mass showed relatively high density on the precontrast CT scan [43 Hounsfield unit (HU)]. There was no remarkable calcification. The mass showed homogenously strong contrast enhancement (mean, 162 HU; maximum, 188 HU; and minimum, 130 HU). In the case presented here, the HU levels of the submandibular oncocytoma on a contrast-enhanced CT is remarkably higher than the HU levels of the salivary gland tumors described in prior literature. If a mass of the salivary gland has strong contrast enhancement on a CT scan, the occurrence of an oncocytoma of the salivary gland may be possible, the possibility of the oncocytoma of the salivary gland may be considered.
Cholesterol Embolism
Authors: Park Seulgee , Cheon Minseok , Kim Jae-Wang
Published: May 2022

Cholesterol embolism is a multi-systemic disease caused by distal showering of cholesterol crystals released fromdisintegration of arterial atheromatous plaque. Cholesterol embolism usually occurs after invasive vascular procedures such asarterial angiography, cardiac catheterization, angioplasty, anticoagulation and thrombolytic therapy. Skin and renal involvementare the most common presentations of cholesterol embolism. Although morbidity and mortality of cholesterol embolism has beenknown to be high, diagnosis may be difficult as a result of the variable clinical presentations. Herein, we report a case ofcholesterol embolism which had been confirmed through the skin biopsy.
Hemosiderotic Dermatofibroma: Histopathologic Differential Diagnosis from Other Variants
of Dermatofibroma and a Variety of Fibrohistiocytic Tumors of Mesenchymal Origin
Authors: Kim Minsu , Cheon Minseok , Kim Jae-Wang
Published: May 2022

Dermatofibroma(benign fibrous histiocytoma) is a relatively common fibrohistiocytic tumor. It has a variety of histologic variantsand the diagnosis may be difficult in atypical or rare cases. Hemosiderotic dermatofibroma is an uncommon pathologic subtypeof dermatofibroma. Histopathologically, it is characterized by widespread deposition of intra- and extracellular hemosiderin,numerous small vessels and extravasated erythrocytes, in addition to the typical features of classic dermatofibroma. It has beenrecognized as a precursor lesion for the development of aneurysmal dermatofibroma. This tumor should be differentiated fromother histologic variants of dermatofibroma and fibrohistiocytic tumors with variable grade of malignancy. Herein, we represent acase of hemosiderotic dermatofibroma occurring in a 32-year-old male.
Anesthetic Experience of a Patient with Congenital Long QT Syndrome
Authors: Kim Jin Young , Kim Hyun Jung
Published: May 2022

Congenital long QT syndrome is a hereditary disorder which is characterized by prolonged QT interval, recurrent syncope,and sudden cardiac death. Special concern is needed in these patients, because fatal ventricular arrhythmia may be happenduring perioperative period. This is a case report of a child with congenital long QT syndrome who underwent ventilation tubeinsertion for middle ear effusion under general anesthesia.
A Case of Gastric Syphilis Diagnosed by PCR Test: A Case Report
Authors: Jo Jaemin , Kim Heung Up , Heo Sang Taek
Published: May 2022

Syphilis is chronic and systemic inflammation caused by T. pallidum infection. Because the diagnosis is exclusively dependedon histology, its diagnosis could be very difficult in the patients without positive biopsy finding. We experienced a case ofgastric syphilis diagnosed by polymerase chain reaction (PCR) in case of biopsy negative patients. So we report this simplemethod to diagnose gastric syphilis that failed to show spirochetes on histology. A 70 year-old man visited our hospital viaprivate clinic with suspicious gastric malignancy finding on gastroscopy. Our gastroscopy showed the characteristic shape ofmultiple nodular erosions and ulcers of gastric syphilis. Warthin-Starry silver stain failed to find spirochetes. Repeatedgastroscopy was done to take biopsy specimen for T. pallidum PCR and proved positive. We confirmed gastric syphilis andtreated with intravenous antibiotics. After 4 months of treatment, all gastric lesions were disappeared.
Pulmonary Aspergillosis Mimicking Malignant Lesions: 2 Cases
Authors: Yang Jieun , Chang Jee Won , Maeng Young-Hee
Published: May 2022

Pulmonary nodules or masses with radiologically indeterminate charateristics should be confirmed pathologically for propertreatment. This study reports two cases of pulmonary nodule or mass with increased SUVmax on the PET-CT which wereconfirmed as aspergillosis infection by surgical resection.
Magnetic Resonance Imaging Findings in the Brains of Patients with CADASIL.
Authors: Lee Jung Seok , Kang Chul-hoo , Oh Jung-Hwan , Song Sook Keun , Choi Jay Chol , Kang Sa-Yoon , Kang Ji-Hoon , Jeon Bong-hee , Park Joon Hyuk
Published: May 2022

Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inheritedmicroangiopathy caused by mutations in the Notch3 gene. Typical findings from magnetic resonance imaging (MRI) includemultiple subcortical lacunes, extensive white matter change and multiple cerebral microbleeds (CMBs). Whereas MRI findings arewell described in Caucasian patients with CADASIL. There is a paucity of data on Asian patients. We aim to characterizedimaging findings in Asian patients with CADASIL. The study population comprised 73 patients who underwent brain MRI betweenMarch 2012 and May 2013. T1-weighted image, susceptibility weighted image (SWI), and fluid attenuated inversion recovery(FLAIR) images were analyzed by visual inspection. Clinical information at time of imaging was available for all patients. Themean age of patients (44 men, 29 women) was 63.2±11.8 (SD). In patients with CADASIL, lacunes (76.7%, 56 of 73), CMBs(74%, 54 of 73), and area of white mater hyperintensities (98.6%, 72 of 73) were observed. Lacunes, CMBs, and WMHs werelocated predominantly in the cortical-subcortical lesion (57.5%, 54.8%, and 98.6%, respectively). These findings suggest thatcortical-subcortical area is the most frequently injured area of brain in CADASIL. Further studies are needed to validate ourfindings.
A case of unilateral cochlear nerve deficiency with congenital hearing loss
Authors: Jang Han-Bin , Kim Dong Young , Song Chan Il , Kim Se-Hyung
Published: May 2022

The narrow bony cochlear nerve canal in high resolution temporal bone computed tomography (TBCT) is frequently found inpatients of congenital sensorineural hearing loss. But this bony structural anomaly could not conclude the functional outcome ofcochlear nerve. Here we present a case of a 10-month-old girl having unilateral narrow bony cochlear nerve canals. In internalauditory magnetic resonance imaging (IAC MRI), the right cochlear nerve was not identified to be intact. Moreover, acousticbrainstem response threshold and automated acoustic brainstem response revealed nearly deaf hearing threshold. Therefore wesuggest that congenital hearing loss patients take TBCT and IAC MRI to rule out the narrow bony cochlear nerve canal.
The management of prostatic diseases according to testosterone replacement therapy
Authors: Lee Jun Hyup , Huh Jung-Sik , Kim Young-Joo , Park Kyung kgi , Kim Sung Dae
Published: May 2022

Late onset hypogonadism (LOH) is defined as a biochemical syndrome associated with advancing age and characterized by adeficiency in serum testosterone with or without decreased tissue sensitivity to testosterone. The precise role of testosterone inthe aging process of men remains unclear, and there have been few controlled clinical studies in aging men to investigate theeffects of testosterone replacement therapy on various organs and human functions known to deteriorate with age. The effectof testosterone replacement therapy on the prostate is very important in terms of its safety in aging men. We recommend acareful and individualized evaluation of present health problems combined with assessment of prostatic health (rectalexamination, transrectal ultrasound, and prostate specific antigen(PSA) measurement) be undertaken before testosteronereplacement is initiated. Perhaps the most controversial topic in the ongoing discussion of testosterone-replacement therapy isthe issue of risks of prostatic diseases. Recent reports suggesting increased risks associated with hormone replacement inwomen have aroused concern that men receiving hormone replacement may also be vulnerable to increased health risks.However, no large-scale, long-term studies have yet been initiated to assess the benefits and risks of testosteronereplacementtherapy in men, in part because of theoretical concern regarding the risks of therapy, especially possiblestimulation of prostate cancer by testosterone. The purpose of this review is to discuss what is known and not known regardingthe risks of testosterone replacement therapy and to provide recommendations for the monitoring of men receiving testosteronetreatment.
The Status of Institutions for End-of-Life Care in Jeju and the Role of Jeju Regional Cancer Center
Authors: Hong Han-Sol , Huh Jung-Sik
Published: May 2022

Death has not been avoided then human will die. Improved sanitation, concerted efforts by public health, new science andtechnology, and the development if medical interventions have increased life expectancy. Also, needs to improve the quality oflife for patients with end-of-life has been increased. As care for patients with terminal illnesses has shifted form home toinstitutions, lack of familiarity with dying process and death has appeared. Hospice and palliative care is the part of medicine totake care patients with progressive , far-advanced diseases and short life expectancy, less than 6 months, for whom the focusof care is relief of suffering and the quality of life. Subsequent decades have seen a marked growth in the number ofinstitutions operating in Korea. But, hospice and palliative care still take a care for only a small group for dying patients. Therehave been no data for hospice and palliative care institutions in Jeju. This study is to summary the status of institution for endoflife care in Jeju and role of Jeju regional cancer center. Most hospice professionals dont't have experience of hospicepalliative care. and has not received proper amount of hospice education in Jeju. There are only 3 institutions and 2 volunteergroups in Jeju. In order to take a care patient with terminal illness, the general consensus that end-of-life care must improve,the public still maintains an adequate attitude toward end-of-life and the role of health workers. Jeju regional cancer centerneed to improve education programs of hospice palliative care according to the role of it and offer it for hospice care.
Correlations between Self-Assessment of Communication Skills and Patient-Physician Interaction in Medical Students
Authors: Kim Woo Jeong
Published: May 2022

The purpose of this study was to identify the correlations between medical students’ self-assessment of communicationskills and patient-physician interaction. A total of 36 fourth-year medical students were enrolled in this study and weresurveyed concerning communication skills during clinical performance examination. The survey included 20 items in fourcategories: beginning an interview (greeting, identification, introduction, attention, and chief complaint), gathering information(open question, reflection, facilitation, clarification, and summarizing), giving information (discovering the patient’sunderstanding, empathy, easy terms, checking of understanding, and giving opportunities), and non-verbal communication(neat features, listening, eye contact, nodding, and silence). 20 items of communication skills were modulated to five patientphysicianinteraction items, and compared with patient-physician interaction scores by self-assessment. There were nocorrelations between communication skills and patient-physician interaction scores except one item, making an efforts tounderstand patient’s situation. This study demonstrated that medical education of communication skills could not betransferred to improvement of patient-physician interaction in clinical skills assessment.
Surgical treatment of non-small cell lung cancer in Jeju National University Hospital
Authors: Chang Jee Won , Han Sang hoon
Published: May 2022

We retrospectively reviewed 93 patients (66 men and 27 women) with non-small cell lung cancer who underwentpulmonary resection from March 2009 to February 2014 at Jeju National University Hospital. Operative mortality was 1.1%and significant postoperative morbidity was 6.5%. The proportion of never-smokers, stage I diseases, adenocarcinoma, andwell-differentiated type of cancers were greater in women (88.9% vs 17.5%, 81.5% vs 59.1%, 92.6% vs 51.5%, and 48.1%vs 10.6%, respectively) (p < .001). Rate of recurrence was higher as the pathologic stage was advanced. However, mediantime of recurrence-free survival has limited value because of short period of follow-up. We had acceptable level ofpostoperative mortality and morbidity and should continue to do aggressive postoperative care and to make an effort toavoid pneumonectomy in order to decrease mortality and morbidiyt.
A Case of Neonatal Septic Arthritis Caused by Group B Streptococcus
Authors: Kim Young Don , Song Mi-Hyun , Lee Moo-Sook
Published: May 2022

Group B streptococcus (also indicated as streptococcus agalactiae) is a well-known cause of severe infections in younginfants but also an unusual microorganism to be isolated in case of septic arthritis, especially in newborns in Korea. Wereport a case of monoarticular septic arthritis caused by group B streptococcus in a 22-day-old baby.
Rapid purification of glutarthione S-transferase from Neodiplostomum seoulense
Authors: Choi Min-Ho , Chung Young-Bae
Published: May 2022

The authors partially purified glutathione S-transferase (GST) of Neodiplostomum seoulense monitoring its activity using 1-chloro-2,4-dinitrobenzene (CDNB). The enzyme was partially purified using glutathione?agarose affinity columnchromatography. The purification fold and recovery rate were 9.7 and 50.4%, respectively. The molecular weight of thepurified GST was estimated to be 28 kDa on 7.5-15% gradient SDS-PAGE. From this study, the authors firstly reported thepresence of GST from N. seoulense and further studies such as inhibition test, subclass of GST as well as immunologicalstudies would be required.
Intrinsic positive end-expiratory pressure caused by temporary partial upper airway
obstruction in a patient with bronchiectasis
Authors: Park Ju Seong , Yun So Hui , Park Jong Cook
Published: May 2022

We report the case of a 71-year-old female patient with bronchiectasis who developed temporary partial upper airwayobstruction and intrinsic positive end-expiratory pressure (PEEP) caused by the movement of accumulated secretions from thelower respiratory tract to the upper respiratory tract because of a change in position. Changes in respiratory dynamics and themodification of extrinsic PEEP need to be considered in such patients with intrinsic PEEP.
Drug-induced cardiovascular disorders
Authors: Lee Eunkyoung , Lee Jaechun , Han HyeJung
Published: May 2022

Adverse drug reactions (ADRs) affecting cardiovascular system might be underestimated and underreported in clinicalpractice. Most common culprit drugs are anthracyclines, antipsychotics and cyclooxygenase (COX)-2 inhibitors. Anthracyclinesmay induce myocardial damage with oxidative stress, which is mostly irreversible. Type I ADRs are commonly encountered inantipsychotic use. Attention should be paid to the risk of sudden cardiac death related to some antipsychotics. COX inhibitorspharmacologically have antithrombotic activities. However, in COX2 selective inhibitors, myocardial infarction and stroke might beinduced paradoxically.
A case of huge fibroma in the labium majus
Authors: Han Joon Hee , Shim Soon Sup , Kang Hye Sim , Hyun Chang Lim
Published: May 2022

Fibroma is a rare benign solid tumor of the vulva. In general, they appear as small, soft, and they are mostly located on theaxillae, lateral neck and inguinal lesion. We report a case of huge soft fibroma in the labium majus of a healthy, middle-agedwoman, and such fibroma on the labium majus are very rare.
Right ventricular perforation caused by pulmonary artery catheter at intensive care unit
Authors: Huh InYoung , Kim DaeYoung , Sung MinHa , Lee MinHyun , Park SunEun
Published: May 2022

Pulmonary artery catheter (PAC) is considered the useful hemodynamic monitoring tool in cardiac surgery and intensive careunit (ICU). Placement of PAC has potential risks of complications, though. A various type of complications have been reported.However, right ventricular perforation by PAC is rare finding. In this case, a 68-year-old woman with rheumatic aortic stenosisand mitral stenosis was planned double valve replacement. PAC was not advanced in pulmonary artery during surgery. Aftertransferred ICU, PAC was advanced into right ventricle (RV) with ballooning. A large amount of bleeding and hemodynamicinstability was developed, and then, reoperation was decided. After median sternotomy, surgeon detected the protruding PACtip from the free wall of RV. Direct suture was performed, and catheter tip was withdrawn back into the RV cavity. It is importantto keep in mind that RV perforation could arise after PAC insertion and PAC should be gently handled.
Surgical resection of the benign pulmonary diseases presented with hemoptysis
Authors: Chang Jee Won , Lee Seogjae , Kim Su Wan , Kim Jinsik
Published: May 2022

Role of lung resection for benign pulmonary diseases presented with hemoptysis is still controversial. Weretrospectively reviewed the patients’ records with significant hemoptysis that underwent anatomic pulmonary resectionfrom 2009 to 2015. Among ten patients (male 9, female 1, mean age 52.3 years), eight patients had inflammatorydiseases including aspergilloma or bronchiectasis and nine patients underwent lobectomy or pneumonectomy. Therewas no postoperative mortality and recurrence of hemoptysis. Lung resection is still one of the effective treatmentoptions for benign lung diseases presented with hemoptysis although the number of included patients was small.
Statistical Analysis on Legal Autopsy in Jeju During 2011-2014
Authors: Cheol Ko Kwang , Kang Hyun Wook
Published: May 2022

The aim of this study was to reveal the current status of forensic practice in Jeju Province. The range of subjects was limitedto deaths autopsied in Jeju National University during the years of 2011 through 2014. The total number of autopsies was 451,of these 35 cases unidentified or unknown manner of death for severe decomposition were excluded in this study. A total 416subjects were reviewed with respect to age, sex, cause of death and manner of death. Of these 296 cases were males and120 were females. In age distribution, the age group of 40-49 occupied the highest proportion(26.7%). According to themanner of death, the cases of violent deaths were 280(67.3%), natural deaths; 136(32.7%). For the violent deaths, thepercentage of accidental death was 36.8 and homicide; 14.6, suicide; 24.3, undetermined cases; 24.3. In natural deaths,ischemic heart disease was the leading cause of death(27.9%).
Recurrent Duodenal Stricture and Phytobezoar after Billroth I Operation of Early Gastric
Cancer: A Case Report
Authors: Lim Joon Kyu , Song Hyun Joo , Kim Min Jung
Published: May 2022

Phytobezoars are conglomerates of non-digestible vegetable matter in the gastrointestinal (GI) tract that may be insidious orsymptomatic with general GI manifestations. One of the predisposing factors of phytobezoars is gastric surgery. They candevelop at any site of the gastrointestinal tract; however, duodenal phytobezoar following gastric surgery has been rarelyreported. Small intestinal bezoars often cause small bowel obstruction and ileus. We report a case of recurrent duodenalstricture and phytobezoar which was detected following Billroth I operation for early gastric cancer.
Stevens-Johnson syndrome and toxic epidermal necrolysis: review of concept,
etiopathogenesis, diagnosis and management
Authors: Yoon Hyeon-Ji , Kim Jae-Wang
Published: May 2022

Stevens-Johnson syndrome/toxic epidermal necrolysis are relatively rare but fatal mucocutaneous drug reactions. It isclinically characterized as a blistering, necrosis, epidermolysis, sloughing and scarring of the skin and mucosa. InKorea, these diseases have been increasingly reported over recent years. Because of higher mortalities and seriouscomplications, early diagnosis and prompt withdrawal of culprit drugs by a clinician is paramount for the adequatemanagement of Stevens-Johnson syndrome/toxic epidermal necrolysis. Herein, we review concept, etiopathogenesis,diagnosis and management of Stevens-Johnson syndrome/toxic epidermal necrolysis.
Bilateral Hemorrhagic Adrenal Metastases in Non-Small Cell Lung Cancer:
Uncommon Case report in Korea
Authors: Park Sungjoon , Kim Jeong Jae , Jeong Sun Young , Kim Bong Soo
Published: May 2022

The adrenal gland is one of the common sites for metastasis from lung cancer. However, the development of adrenalhemorrhage from lung cancer metastasis is rare. We herein describe a first case of massive, spontaneous bilateraladrenal hemorrhage secondary to metastatic lung cancer, initially presented with severe flank pain in Korea.
A Case Report of a Spontaneous Incarcerated Transomental Hernia through a Defect in
Gastrocolic Ligament with a Review of Domestic Literature on Transomental Internal Hernia
Authors: Kim Young-Kyu , Her Kyu Hee , Kim Kwang Sig
Published: May 2022

Incarcerated transomental hernias through a defect in the gastrocolic ligament are extremely rare. A woman aged 51who had upper abdominal pain for 5 hours was admitted to the emergency department of Jeju National UniversityHospital. Abdominal computed tomography images revealed a protrusion of a jejunal segment into a lesser sac (omentalbursa) with mild wall thickening, decreased perfusion of bowel wall and perivascular fatty infiltrations in its mesentery.These findings suggested an incarcerated transomental hernia into the lesser sac (omental bursa). She underwent adiagnostic laparoscopy immediately. On the operative finding, there was a defect about 4 cm long in gastrocolic ligamentand the jejunal segment which was about 60 cm long and its mesentery were herniated through the defect. A reductionof the jejunal segment and repair of the defect were totally done via laparoscopy. She was discharged on postoperativeday 3 uneventfully. Herein we reports about an experience of a spontaneous incarcerated transomental hernia of smallintestine through a defect in gastrocolic ligament and its successful laparoscopic surgical treatment with a review ofdomestic literatures.
B-cell cutaneous lymphoid hyperplasia: report of two cases and histopathologic
differentiation of cutaneous B-cell lymphoma
Authors: Han Ga-In , Kim Jae-Wang
Published: May 2022

B-cell cutaneous lymphoid hyperplasia (B-cell pseudolymphoma) represents a heterogeneous group of benign reactivelymphoproliferative diseases caused by polyclonal B-cell rich lymphocytic infiltrates, simulating the appearance of acutaneous B-cell lymphopma clinically and/or histologically. A histopathologic differentiation of cutaneous lymphoidhyperplasia with follicular growth pattern from follicle center cell lymphoma is important. However, the differentiationbetween cutaneous lymphoid hyperplasia and cutaneous lymphoma is somewhat difficult and close long-term follow-upmay be necessary. Herein, we present two cases of B-cell cutaneous lymphoid hyperplasia with a clinico-pathologicreview of the literature.
Ureterovesical Junction Stricture on Diuretic and Dual-time-point FDG PET/CT
Mimicking Recur of Colon Cancer
Authors: Han Sanghoon , Song Heesung
Published: May 2022

FDG PET/CT is a useful modality to detect recurred lesions of many malignancies. Because a lot of FDG is excreted throughurinary system, FDG PET/CT is limited especially in the cases of pelvic cavity. To overcome these restrictions diuretic or dualtime-point FDG PET/CT has been introduced and improved the specificity and sensitivity. Herein this report presents falsepositivefindings of diuretic and dual-time-point FDG PET/CT which mimicked a recurrence of sigmoid colon cancer due to anureterovesical junction stricture.
Epidural Anesthesia for Pelvic fracture in a Patient with dilated cardiomyopathy
- Case Report -
Authors: Na Chang Rock , Cho Suk Ju
Published: May 2022

Dilated cardiomyopathy (DCM) is defined as a primary heart muscle disorder characterizedby decreased myocardialcontractility, impairment of the ventricular function of the myocardium. The management of a patient with dilatedcardiomyopathy is always a challenge for an anesthesiologist, as this situation is associated with severe cardiac failureand a high mortality rate during or after anesthesia. We report the successful anesthetic management of a patient withdilated cardiomyopathy undergoing surgery for pelvic fracture.
Modulatory function of calcium excitability in astrocytes by
NMDA receptor antagonists
Authors: Oyunbileg Dash , Park Joo-Min , Eun Su-Yong , Jung Sung-Cherl
Published: May 2022

Astrocytes, the predominant cell type in central nervous system, are electrically non-excitable cells. However, astrocytesdisplay their excitability by increasing intracellular calcium concentration. Several lines of evidence have highlighted theimportance of astrocytic calcium excitability in both physiological and pathological conditions. Here, we investigated the effectsof dissociated anesthetics: ketamine and MK-801 (dizocilpine) known as NMDA (N-methyl-D-aspartate) receptor antagonists, oncalcium excitability in mouse cortical astrocytes. We further compared the effects of Ketamine and MK-801 on astrocyticserotonin (5-HT) receptors. In cultured cortical astrocytes, MK-801 increased intracellular calcium concentration and led tofurther increases in calcium in the presence of 5-HT. However ketamine had no effect on the calcium response in astrocytes.These results suggest that the calcium concentration in astrocytes is reinforced by MK-801 under the modulation of serotoninreceptors.
Extraneural soft tissue perineurioma
Authors: Yoon Hyeon-Ji , Kim Jae-Wang
Published: May 2022

Perineuriomas(tumors of perineurial cells) are relatively rare, benign peripheral nerve sheath-originated neoplasms, presentingextraneural or intraneural tumors. Extraneural perineuriomas seem to be more common than intraneural perineuriomas.Extraneural perineuriomas are found mainly in skin and soft tissues. Soft tissue perineurioma is a kind of extraneuralperineuriomas, and it is the most common type of perineuriomas. Histopathologically, soft tissue perineurioma is characterized bywell-circumscription, fibromyxoid stroma, and bland spindle cells representing the fascicles or whirling growth pattern, which isaccentuated on the perivascular zones. Herein, we present one case of extraneural soft tissue perineurioma occurring on thelower back region.
Interstitial granulomatous dermatitis occurring in the patient with
breast cancer: report of one case and a review on interstitial
granulomatous dermatitis
Authors: Han Ga-In , Kim Jae-Wang
Published: May 2022

Interstitial granulomatous dermatitis is a rare skin disorder in which there is a particular pattern of granulomatous inflammationassociated with rheumatologic diseases, hematologic disorders or underlying malignancies. The most common clinical findings ofinterstitial granulomatous dermatitis are multiple erythematous papules or plaques occurring on the varied sites.Histopathologically, it is characterized by dense perivascular and interstitial histiocytic infiltration around focally degeneratedcollagen fibers in the reticular dermis. We present a case of interstitial granulomatous dermatitis occurring in the patient withbreast cancer.
Effect of Supplementation of Jeju Magma Seawater on Glucose Transport in
Cultured L6 Skeletal Muscle Cells
Authors: Ma Gun Jung , Kim Soo Jung , Park Deok Bae
Published: May 2022

Magma seawater, the underground seawater in Jeju island, contains abundant minerals. Previous studies have suggested thebeneficial effect of deep seawater on hyperlipidemia and cardiovascular diseases. We investigated the in vitro effect of magmaseawater on the glucose transport by skeletal muscle cells, a key regulatory mechanism to maintain blood glucose levels.Stepwise supplementation of magma seawater (898-1,898 of hardness) to the cell culture mdieum did not affect the viability ofL6 myoblasts. In differentiated L6 skeletal muscle cells, the supplementation of magma seawater elevated the basal- andinsulin-induced glucose transport into cells. Akt and AMPK, insulin-dependent and ?independent signaling pathways to leadglucose transport respectively, were stimulated by the supplementation of magma seawater to the culture medium. Takentogether, magma seawater of Jeju has a physiological potential to maintain body glucose homeostasis.
Eutypella species Isolated from a BronchoAlveolar Lavage
in a Patient with Small Cell Lung Cancer
Authors: Yeo Seung Joo , Kim Young Ree , Kim Bong Chan , Kang Sung Ha
Published: May 2022

The Eutypella is a genus of fungi in the family Diatrypaceae, and well-known plant pathogens, is capable of infecting manyspecies of maple trees. We introduce here a case of Eutypella species isolated from a bronchoalveolar lavage in animmunocompromised patient with small cell lung cancer initially not suspected by SDA and LPCB stain and revealed by PCRand 18S rDNA sequencing. But, in this case, we couldn't judge whether this fungus was the pathogen for inflammation of lungand additional treatment was not needed for fungus isolation with no clinical problems. The human mycobiome includes 390fungal species detected on the skin, in the vagina, in the oral cavity, and in the digestive tract that includes 335 species and158 genera. Among these, 221 species are found only in the digestive tract, 88 only in the oral cavity, and 26 in both. Thesespecies belong to 126 genera of yeast and filamentous fungi, of the Ascomycota, Basidiomycota, and Zygomycota phyla. So, nomatter how sensitive the diagnosis is, the results of molecular diagnosis method for fungal infection must be carefullyconsidered with clinical conditions..
Significance of antenatal chlamydia trachomatis infection screening test
Authors: Kang Hye Sim
Published: May 2022

Objective:The objective of this study was to estimate the prevalence for Chlamydia trachomatis infection in first trimester pregnancy inkorea.Methods:From March, 2013 to December, 2015, Chlamydia trachomatis screening test were performed on women who visited theoutpatient clinic for antenatal check. Specimens are taked from the endocervix or vagina and analysed by polymerase chainreaction. Medical records including age, parity, pregnancy outcome were reviewed.Results:Total 199 women were tested at first trimester pregnancy, of those tested women, 3.52% and 0% tested positive forchlaymydia and gonococcal infection. There were no significant difference between the infected and noninfected group. Duringthe same period, the prevalence of chlamydia in those who were diagnosed pelvic inflammatory disease was 9.6% (15/156).Conclusion:According to the current Centers for Disease Control and Prevention(CDC) guidelines, all pregnant women should be routinelyscreened for Chlamyidia trachomatis at the first prenatal visit. The reported Chlamydia prevalence in the united states in 2012was 3.5%, this prevalence is similar to our country. Therefore the screening and treatment of Chlamydia trachomatis arenecessary to prevention of obstetrical complication and neonatal infection.
Association of biomarkers between erectile dysfunction
and cardiovascular risk prediction
Authors: Kim Jun-Yong , Park Kyung Kgi , Kim Young Joo , Huh Jung-Sik , Kim Sung Dae
Published: May 2022

Epidemiological studies suggest atherosclerosis as a common risk factor between cardiovascular diseases and erectiledysfunction (ED). We aimed to determine the association between erectile function and the biomarkers of subclinicalatherosclerosis. A number of circulating and imaging biomarkers are robustly associated with cardiovascular (CV) risk. Theoverall expectationfrom a biomarker in the erectile dysfunction (ED) setting is to enhance the optimal management of a man withthis disorderbut no clinical atherosclerosis. Evidence demonstrating that these biomarkers enhance risk prediction for individualswith EDis at this stage still limited for most of them. A better identification of the subsets of the ED population that requirefurther riskstratification, as well as the initiation of randomized trials that will formally test the ability of biomarkers to predict CVrisk, couldmake biomarker?guided prevention an attainable goal.
Mathematical modeling and analysis of Phytoplankton–Zooplankton–Nanoparticle dynamics
Authors:   Department of Mathematics, College of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur, Tamilnadu, India, Suganya G. , Senthamarai R. ,   Department of Mathematics, College of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur, Tamilnadu, India
Published: May 2022

In this paper, we investigate the population dynamics of phytoplankton–zooplankton–nanoparticle model with diffusion and density dependent death rate of predator. The functional response of predator in this model is considered as Beddington–DeAngelis type. The stability analysis of the equilibrium points is observed by applying the Routh–Hurwitz criterion. Numerical simulations are given to illustrate the theoretical results.
Thermomechanical behavior of a solid electroconductive ball under the action of amplitude modulated radioimpulse
Authors:   Lviv Polytechnic National University, Musii R. S. , Melnyk N. B. ,   Lviv Polytechnic National University, Drohomyretska Kh. T. ,   Lviv Polytechnic National University, Duza-Zadorozhna M. P. ,   Lviv Polytechnic National University, Druzhbiak S. V. ,   Lviv Polytechnic National University
Published: May 2022

A physical and mathematical model for determining the thermostressed state of an electroconductive solid ball under the action of an amplitude modulated radioimpulse is proposed. The centrally symmetric problem of thermomechanics for the considered ball is formulated. The azimuthal component of the magnetic field strength vector, temperature, and the radial component of the displacement vector were chosen as the determining functions. To construct solutions of the formulated components of the initial-boundary value problems of electrodynamics, heat conductivity, and thermoelasticity, a polynomial approximation of the determining functions over the radial variable is used. As a result, the initial-boundary value problems on the determining functions are reduced to the corresponding Cauchy problems on the integral characteristics of these functions over the radial variable. General solutions of Cauchy problems under homogeneous nonstationary electromagnetic action are obtained. Based on these solutions, the change in time of Joule heat, ponderomotor force, temperature and stresses in the ball under the action of amplitude-modulated radioimpulse depending on its amplitude-frequency characteristics and duration is numerically analyzed.
Improving students’ reading comprehension in narrative text through schema activation strategy at third grade at SMPN 1 Bukit Kemuning Lampung Utara
Authors:   Universitas Lampung, Shalehuddin Muhammad , Munifatullah Feni ,   Universitas Lampung, Nurdiana Novita ,   Universitas Lampung
Published: May 2022

The objectives of this research are to investigate whether there is a significant difference in the students’ reading comprehension achievement before and after the implementation of schemata activation strategy and which aspect that improves the most in reading comprehension after being taught schema activation strategy. This research was conducted at the third-grade students of SMPN 1 Bukit Kemuning in the academic year 2020/2021. The researcher took class IX. The instrument used to get the data in this research was a reading comprehension test. Reading tests in the forms of pre-test and post-test were done to collect the data. Then, the t-test was used to test the hypothesis. The result of the hypothesis test proves that schemata activation gives a positive effect on students’ reading comprehension achievement. In addition, determining reference was the aspect of reading skills which improved the most after being taught by Schema Activation Strategy. This evidence proved that teaching reading using Schema Activation Strategy facilities more in determining reference. In conclusion, this study suggests that Schema Activation Strategy can be used to improve students’ reading comprehension.
Communicative language teaching in improving Student’s speaking achievement
Authors:   Universitas Lampung, Setianingsih Retno , Mahpul Mahpul ,   Universitas Lampung, Sholihah Lilis ,   Universitas Lampung
Published: May 2022

The aim of the research was to find out whether there is an improvement in the students’ speaking achievements after being taught through the weak version of the Communicative Language Teaching method. The population of the research was the students of the second year of SMKN 2 Bandar Lampung. The sample of the research was twenty students of Eleventh Grade BKP (Bisnis Konstruksi dan Property) 3. The research used one group pre-test post-test design and the data were taken from the tests. The data were analyzed by using SPSS statistics 20. The result of the research indicated that there was a significant improvement in the students’ speaking achievement after being taught through the Communicative Language Teaching method. The mean score of the post-test (9.8) was higher than the mean score of the pre-test (7.2). By using the t-test, it was found that the sig (p) value is less than the sig level 0,05 (0.000 < 0.05) and the t-value (8.664) was higher than the t-table (1.729). It can be concluded that the implementation of the weak version of the Communicative Language Teaching method significantly improved students’ speaking achievement.
The effect of Time Token Arends as cooperative learning types on the students’ speaking skills at eleventh grade of SMAN 1 Bandar Lampung
Authors:   Universitas Lampung, Adam Muhammad Rifki Haikal , Supriyadi Deddy ,   Universitas Lampung, Nurdiana Novita ,   Universitas Lampung
Published: May 2022

This research was aimed to find out the effect of Time Token Arends to students speaking skills aspects. This research applied qualitative and quantitative research by using the cooperative learning method. In taking the sample, the researcher used the purposive sampling technique. The number of the sample is 36 students at XI MIPA 1 SMAN 1 Bandar Lampung. The instrument of this research was an observation sheets, documentation and speaking test. There were 2 lesson plans and worksheets for the speaking test. The finding showed that there was a significant difference of students after being taught by using Time Token Arends strategy. Mean score of Pre-test was 58.7 and mean score of first Post-test was 69.1 and second Post-test was 76.1. Accent aspect increased 4.00, vocabulary aspect increased 3.33, comprehension aspect increased 3.34, fluency aspect increased 2.80, and grammar aspect increased 1.73.; it assumed that this technique has positive effect toward students speaking ability.
Project Based Learning, Problem Based Learning Dalam Meningkatkan Kemampuan Pemahaman Konsep Matematis
Authors: Herawati Teti , Turmudzi Didi , Yaniawati R. Poppy
Published: May 2022

Penelitian ini bertujuan untuk mengetahui perbedaan kemampuan pemahaman matematis dan motivasi antara siswa yang menggunakan metoda Project Based Learning dan  siswa yang menggunakan metoda Problem Based Learning ditinjau dari gender (laki-laki dan perempuan). Metode yang digunakan dalam penelitian ini  yaitu metoda Kausal Komparatif dengan teknik analisis data Mixed Method  (kualitatif dan kuantitatif) konvergen. Populasinya adalah seluruh siswa kelas VIII SMPN 3 Banjaran Majalengka, sampel kelas VIII A dan VIII B. Instrumen yang digunakan adalah tes kemampuan pemahaman, motivasi, wawancara dan lembar observasi. Hasil penelitian menunjukan bahwa tidak terdapat perbedaan kemampuan pemahaman matematis dan motivasi antara siswa yang menggunakan metoda Project Based Learning dan  siswa yang menggunakan metoda Problem Based Learning ditinjau dari gender (laki-laki dan perempuan). Hasil lain juga menunjukan tidak ada hubungan antara motivasi dengan kemampuan pemahaman matematis. Motivasi siswa baik di kelas PBL dan PjBL mengalami peningkatan, dikarenaka kedua metoda tersebut merupakan metoda yang menuntut siswa lebih aktif dan dengan pemberian masalah di awal pembelajaran siswa menjadi lebih bersemangat dalam belajar matematika.
Pengembangan E-Modul Berbantuan Sigil Software Dan Analisis Kemampuan Berpikir Kritis Siswa
Authors: Malik Acep Saeful
Published: May 2022

Pengembangan E-Modul Berbantuan Sigil Software Dan Analisis Kemampuan Berpikir Kritis Siswa. Penelitian pengembangan ini bertujuan untuk : (1) Menghasilkan e-modul berbantuan sigil software pada materi kaidah pencacahan, (2) Menganalisis kemampuan berpikir kritis siswa dalam penggunaan e-modul berbantuan sigil software setelah pada materi kaidah pencacahan. Penelitian dan pengembangan ini mengacu pada langkah-langkah desain pengembangan yang dikembangkan oleh Alessi & Trollip. Desain pengembangan tersebut terdiri dari tiga tahap, meliputi : (a) tahap perencanaan (planning), (b) tahap desain (design), dan (c) tahap pengembangan (development). Uji coba produk terdiri dari uji alfa dan uji beta. Uji alfa dilakukan oleh dua ahli materi dan dua ahli media. Sedangkan uji beta terdiri dari dua tahap pengumpulan data, yaitu uji beta 1 dan uji beta 2. Pada uji beta 1 melibatkan 30 siswa kelas XII. Uji beta 2 melibatkan 27 siswa kelas XI SMKN Peternakan Lembang. Pengumpulan data menggunakan angket untuk ahli materi, angket untuk ahli media, angket respon siswa, dan instrumen tes. Penelitian ini (1) menghasilkan e-modul berbantuan sigil software pada materi kaidah pencacahan, (2) produk yang dihasilkan efektif untuk digunakan dalam meningkatkan kemampuan berpikir kritis, terbukti dengan penilaian ahli materi sebesar 4.19, penilaian ahli media sebesar 3.97, dan nilai effect size sebesar 4.37.
Peningkatan Kemampuan Problem Solving Dan Representasi Matematis Dengan Menggunakan Pembelajaran Problem Based Learning
Authors: Astria Kikky
Published: May 2022

Penelitian ini merupakan penelitian mixed method dengan desain concurrent embedded strategy yang difokuskan pada kemampuan problem solving dan kemampuan representasi matematis siswa SMK PGRI 3 Cianjur dengan menggunakan pembelajaran Problem Based Learning. Tujuan penelitian ini adalah : untuk mengetahui apakah pembelajaran dengan Problem Based Learning dapat meningkatkan kemampuan problem solving dan kemampuan representasi matematis siswa pada pembelajaran matematika; untuk mengetahui kemampuan problem solving siswa yang menggunakan pembelajaran Problem Based Learning lebih baik dari pembelajaran biasa; untuk mengetahui kemampuan representasi matematis siswa yang menggunakan pembelajaran Problem Based Learning lebih baik dari pembelajaran biasa; untuk mengetahui apakah ada korelasi antara problem solving siswa dan kemampuan representasi matematis siswa dengan menggunakan model pembelajaran Problem Based Learning; untuk mengetahui bagaimanakah aktivitas siswa pada saat pembelajaran Problem Based Learning. Penelitian ini merupakan dilakukan di kelas X SMK PGRI 3 Cianjur. Instrumen yang digunakan dalam penelitian ini berupa: lembar observasi, wawancara, jurnal harian siswa, angket dan tes kemampuan problem solving dan representasi matematis siswa. Dari data yang diperoleh hasil: Pembelajaran dengan menggunakan Problem Based Learning dapat meningkatkan kemampuan problem solving matematis siswa pada pembelajaran matematika; Pembelajaran dengan menggunakan Problem Based Learning dapat meningkatkan kemampuan representasi matematis siswa pada pembelajaran matematika; Peningkatan kemampuan problem solving siswa yang menggunakan pembelajaran Problem Based Learning lebih baik dari pembelajaran biasa; Peningkatan kemampuan representasi matematis siswa yang menggunakan pembelajaran Problem Based Learning lebih baik dari pembelajaran biasa; Terdapat korelasi antara sikap siswa terhadap Problem Based Learning problem solving dengan peningkatan kemampuan problem solving dan representasi matematis siswa. Berdasarkan uraian di atas, dapat disimpulkan bahwa m Problem Based Learning dapat meningkatkan kemampuan problem solving dan representasi matematis siswa.
Penerapan stategi Model Pembelajaran Problem Based Learning untuk Meningkatkan Kemampuan Berpikir Kritis dan Berfikir Kreatif serta Pengaruh Terhadap Motivasi Belajar Siswa MTS
Authors: Rohendi Edi
Published: May 2022

Penelitian ini bertujuan untuk meningkatkan kemampuan berpkir kritis dan kemampuan berfikir kreatif serta pengaruh terhadap motivasi belajar siswa Mts. Model yang diterapkan dalam pembelajaran adalah Problem Based Learning. Sampel dalam penelitian ini berjumlah 60 orang siswa yang duduk di kelas VIII di Mts Al Mukhlisin Kabupaten Bandung. Kesimpulan dalam penelitian ini adalah kemampuan berfikir kritis matematis dan kemampuan berfikir kreatif siswa yang mendapatkan pembelajaran matematika dengan model Problem Based Learning lebih baik dari pada siswa yang mendapatkan pembelajaran matematika dengan model konvensional, gambaran peningkatan kemampuan berpikir kritis matematis dan kemampuan berfikir kreatif siswa yang mendapatkan pembelajaran matematika dengan model Problem Based Learning lebih baik dari pada siswa yang mendapatkan pembelajaran matematika dengan model konvensional, terdapat   korelasi      antara      kemampuan    berpikir     kritis matematis   dengan kemampuan berfikir kreatif, dan ada korelasi antara kemampuan berfikir kritis matematis dan kemampuan berfikir kreatif serta pengaruh terhadap motivasi belajar siswa.