bluuebunny/crossref_metadata_2025 huggingface dataset:
Author Correction: CryoEM structure of Saccharomyces cerevisiae U1 snRNP offers insight into alternative splicing
Authors: Li Xueni , Liu Shiheng , Jiang Jiansen , Zhang Lingdi , Espinosa Sara , Hill Ryan C. , Hansen Kirk C. , Zhou Z. Hong , Zhao Rui
Published: April 2018

The originally published version of this Article contained several errors in Figure 2, panel a: the basepair register in SL3-4 of yeast U1 snRNA was depicted incorrectly; the basepair for A287-U295 in yeast U1 snRNA was erroneously present; basepairs for U84-G119, G309-U532, A288-U295 and U289-A294 in yeast U1 snRNA were missing; the bulging nucleotide in SL3 of human U1 snRNA was depicted as G instead of C; and the dashed boxes defining the 5′ ss binding site and Sm site in both human and yeast snRNAs were not drawn accurately. These have now been corrected in both the PDF and HTML versions of the Article.
Author Correction: FUT2 non-secretor status is associated with altered susceptibility to symptomatic enterotoxigenic Escherichia coli infection in Bangladeshis
Authors: Mottram Lynda , Wiklund Gudrun , Larson Göran , Qadri Firdausi , Svennerholm Ann-Mari
Published: April 2018

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
Publisher Correction: Role of Dopamine D2 Receptor in Stress-Induced Myelin Loss
Authors: Choi Mi-Hyun , Na Ji Eun , Yoon Ye Ran , Lee Hyo Jin , Yoon Sehyoun , Rhyu Im Joo , Baik Ja-Hyun
Published: April 2018

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
Author Correction: Salinity stratification controlled productivity variation over 300 ky in the Bay of Bengal
Authors: Da Silva R. , Mazumdar A. , Mapder T. , Peketi A. , Joshi R. K. , Shaji A. , Mahalakshmi P. , Sawant B. , Naik B. G. , Carvalho M. A. , Molletti S. K.
Published: April 2018

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
Optical interrogation of neuronal circuitry in zebrafish using genetically encoded voltage indicators
Authors: Miyazawa Hiroaki , Okumura Kanoko , Hiyoshi Kanae , Maruyama Kazuhiro , Kakinuma Hisaya , Amo Ryunosuke , Okamoto Hitoshi , Yamasu Kyo , Tsuda Sachiko
Published: April 2018

Optical measurement of membrane potentials enables fast, direct and simultaneous detection of membrane potentials from a population of neurons, providing a desirable approach for functional analysis of neuronal circuits. Here, we applied recently developed genetically encoded voltage indicators, ASAP1 (Accelerated Sensor of Action Potentials 1) and QuasAr2 (Quality superior to Arch 2), to zebrafish, an ideal model system for studying neurogenesis. To achieve this, we established transgenic lines which express the voltage sensors, and showed that ASAP1 is expressed in zebrafish neurons. To examine whether neuronal activity could be detected by ASAP1, we performed whole-cerebellum imaging, showing that depolarization was detected widely in the cerebellum and optic tectum upon electrical stimulation. Spontaneous activity in the spinal cord was also detected by ASAP1 imaging at single-cell resolution as well as at the neuronal population level. These responses mostly disappeared following treatment with tetrodotoxin, indicating that ASAP1 enabled optical measurement of neuronal activity in the zebrafish brain. Combining this method with other approaches, such as optogenetics and behavioural analysis may facilitate a deeper understanding of the functional organization of brain circuitry and its development.
Ensemble of European regional climate simulations for the winter of 2013 and 2014 from HadAM3P-RM3P
Authors: Schaller Nathalie , Sparrow Sarah N. , Massey Neil R. , Bowery Andy , Miller Jonathan , Wilson Simon , Wallom David C.H. , Otto Friederike E.L.
Published: April 2018

Large data sets used to study the impact of anthropogenic climate change on the 2013/14 floods in the UK are provided. The data consist of perturbed initial conditions simulations using the Weather@Home regional climate modelling framework. Two different base conditions, Actual, including atmospheric conditions (anthropogenic greenhouse gases and human induced aerosols) as at present and Natural, with these forcings all removed are available. The data set is made up of 13 different ensembles (2 actual and 11 natural) with each having more than 7500 members. The data is available as NetCDF V3 files representing monthly data within the period of interest (1st Dec 2013 to 15th February 2014) for both a specified European region at a 50 km horizontal resolution and globally at N96 resolution. The data is stored within the UK Natural and Environmental Research Council Centre for Environmental Data Analysis repository.
The Alexandria library, a quantum-chemical database of molecular properties for force field development
Authors: Ghahremanpour Mohammad M. , van Maaren Paul J. , van der Spoel David
Published: April 2018

Data quality as well as library size are crucial issues for force field development. In order to predict molecular properties in a large chemical space, the foundation to build force fields on needs to encompass a large variety of chemical compounds. The tabulated molecular physicochemical properties also need to be accurate. Due to the limited transparency in data used for development of existing force fields it is hard to establish data quality and reusability is low. This paper presents the Alexandria library as an open and freely accessible database of optimized molecular geometries, frequencies, electrostatic moments up to the hexadecupole, electrostatic potential, polarizabilities, and thermochemistry, obtained from quantum chemistry calculations for 2704 compounds. Values are tabulated and where available compared to experimental data. This library can assist systematic development and training of empirical force fields for a broad range of molecules.
A data discovery index for the social sciences
Authors: Krämer Thomas , Klas Claus-Peter , Hausstein Brigitte
Published: April 2018

This paper describes a novel search index for social and economic research data, one that enables users to search up-to-date references for data holdings in these disciplines. The index can be used for comparative analysis of publication of datasets in different areas of social science. The core of the index is the da|ra registration agency’s database for social and economic data, which contains high-quality searchable metadata from registered data publishers. Research data’s metadata records are harvested from data providers around the world and included in the index. In this paper, we describe the currently available indices on social science datasets and their shortcomings. Next, we describe the motivation behind and the purpose for the data discovery index as a dedicated and curated platform for finding social science research data and gesisDataSearch, its user interface. Further, we explain the harvesting, filtering and indexing procedure and give usage instructions for the dataset index. Lastly, we show that the index is currently the most comprehensive and most accessible collection of social science data descriptions available.
Synthesis and physical properties of brominated hexacene and hole-transfer properties of thin-film transistors
Authors: Watanabe Motonori , Miyazaki Takaaki , Matsushima Toshinori , Matsuda Junko , Chein Ching-Ting , Shibahara Masahiko , Adachi Chihaya , Sun Shih-Sheng , Chow Tahsin J. , Ishihara Tatsumi
Published: April 2018

A halide-substituted higher acene, 2-bromohexacene, and its precursor with a carbonyl bridge moiety were synthesized.
Designing well-defined photopolymerized synthetic matrices for three-dimensional culture and differentiation of induced pluripotent stem cells
Authors: Ovadia Elisa M. , Colby David W. , Kloxin April M.
Published: April 2018

In this work, we establish an approach for the three-dimensional (3D) culture and differentiation of induced pluripotent stem cells (iPSCs) within well-defined synthetic matrices using light-based chemistries of relevance for the study of both disease and regeneration.
Correction: A luminescent bimetallic iridium(iii) complex for ratiometric tracking intracellular viscosity
Authors: Liu Fengyu , Wen Jia , Chen Su-Shing , Sun Shiguo
Published: April 2018

Correction for ‘A luminescent bimetallic iridium(iii) complex for ratiometric tracking intracellular viscosity’ by Fengyu Liu et al., Chem. Commun., 2018, 54, 1371–1374.
Optical readout of controlled monomer–dimer self-assembly
Authors: Tarakanov Pavel A. , Tarakanova Ekaterina N. , Dorovatovskii Pavel V. , Zubavichus Yan V. , Khrustalev Victor N. , Trashin Stanislav A. , De Wael Karolien , Neganova Margarita E. , Mischenko Denis V. , Sessler Jonathan L. , Stuzhin Pavel A. , Pushkarev Victor E. , Tomilova Larisa G.
Published: April 2018

Diazepinoporphyrazines as optical signaling agents.
Modulatingp-hydroxycinnamate behavior as a ditopic linker or photoacid in copper(ii) complexes with an auxiliary pyridine ligand
Authors: Soldevila-Sanmartín Joan , Calvet Teresa , Font-Bardia Merce , Domingo Concepción , Ayllón José A. , Pons Josefina
Published: April 2018

p-Hydroxycinnamate behaves either as a ditopic linker or as a photoacid in copper(ii) complexes with a suitable auxiliary pyridine ligand.
Cage-like crystal packing through metallocavitands within a cobalt cluster-based supramolecular assembly
Authors: Kang Philjae , Mai Hien Duy , Yoo Hyojong
Published: April 2018

The generation of cage-like crystal packing geometry of TSHs in the solid state induced by the host–guest interactions among metallocavitands.
Methylene-bridged bimetallic bis(imino)pyridine-cobaltous chlorides as precatalysts for vinyl-terminated polyethylene waxes
Authors: Chen Qiang , Zhang Wenjuan , Solan Gregory A. , Liang Tongling , Sun Wen-Hua
Published: April 2018

Dicobalt precatalysts displayed high activities for polymerizing ethylene to highly linear vinyl-polyethylenes.
Correction: Selenium effects on the metabolism of a Se-metabolizing Lactobacillus reuteri: analysis of envelope-enriched and extracellular proteomes
Authors: Pessione E. , Lamberti C. , Pessione A. , Galano E. , Amoresano A. , Mangiapane E.
Published: April 2018

Correction for ‘Selenium effects on the metabolism of a Se-metabolizing Lactobacillus reuteri: analysis of envelope-enriched and extracellular proteomes’ by E. Mangiapane et al., Mol. BioSyst., 2014, 10, 1272–1280.
Synthesis of C-functionalized TE1PA and comparison with its analogues. An example of bioconjugation on 9E7.4 mAb for multiple myeloma 64Cu-PET imaging
Authors: Le Bihan Thomas , Navarro Anne-Sophie , Le Bris Nathalie , Le Saëc Patricia , Gouard Sébastien , Haddad Ferid , Gestin Jean-François , Chérel Michel , Faivre-Chauvet Alain , Tripier Raphaël
Published: April 2018

Functionalisation of a TE1PA ligand to make it bifunctional, while maintaining its chelating properties.
A strategy for the molecular design of aggregation-induced emission units further modified by substituents
Authors: Peng Zhe , Ji Yingchun , Huang Zihan , Tong Bin , Shi Jianbing , Dong Yuping
Published: April 2018

Aryl-substituted pyrrolo[3,2-b]pyrrole as a new AIE unit modified by different electron-withdrawing or electron-donating substituents to obtain AIEgens.
Anisotropic tough poly(vinyl alcohol)/graphene oxide nanocomposite hydrogels for potential biomedical applications
Authors: Luo Qiaomei , Shan Yangyang , Zuo Xia , Liu Jiaqi
Published: April 2018

Tough PVA/GO nanocomposite hydrogel with well-developed anisotropic microstructure and excellent mechanical properties.
Nickel-iron catalysts for electrochemical water oxidation – redox synergism investigated by in situ X-ray spectroscopy with millisecond time resolution
Authors: González-Flores Diego , Klingan Katharina , Chernev Petko , Loos Stefan , Mohammadi Mohammad Reza , Pasquini Chiara , Kubella Paul , Zaharieva Ivelina , Smith Rodney D. L. , Dau Holger
Published: April 2018

NiFe oxyhydroxides are prime candidates for efficient alkaline water oxidation; their redox chemistry is tracked by X-ray spectroscopy.
Textured surfaces as a new platform for nanoparticle synthesis
Authors: Baştopçu Melih , Derinöz Anıl E. , Yılmaz Asil C. , Erdem E. Yegan
Published: April 2018

A surface based microfluidic platform that synthesizes and transports nanoparticles using local surface energy gradients is presented.
Ionic structure around polarizable metal nanoparticles in aqueous electrolytes
Authors: Petersen Bendix , Roa Rafael , Dzubiella Joachim , Kanduč Matej
Published: April 2018

The high polarizability of neutral metal nanoparticles dictates their electrostatic character in electrolyte solutions.
Microenvironment alterations enhance photocurrents from photosystem I confined in supported lipid bilayers
Authors: Niroomand Hanieh , Pamu Ravi , Mukherjee Dibyendu , Khomami Bamin
Published: April 2018

This work elucidates the role of natural membrane confinements of photosystem I complexes (PSI) in light-induced charge separation by comparing the photocurrents of isolated PSI with PSI encapsulated within solid-supported lipid bilayers on electrodes. Our results indicate the critical role of the microenvironment alterations in achieving enhanced photocurrent and stability.
Designed synthesis of NiCo-LDH and derived sulfide on heteroatom-doped edge-enriched 3D rivet graphene films for high-performance asymmetric supercapacitor and efficient OER
Authors: Qin Kaiqiang , Wang Liping , Wen Shuaiwei , Diao Lechen , Liu Peng , Li Jiajun , Ma Liying , Shi Chunsheng , Zhong Cheng , Hu Wenbin , Liu Enzuo , Zhao Naiqin
Published: April 2018

A high-quality edge-enriched H-3DRG film coupled with vertically oriented electroactive inorganics for high performance asymmetric supercapacitors and OER.
Single-atom catalysts and their applications in organic chemistry
Authors: Yan Huan , Su Chenliang , He Jun , Chen Wei
Published: April 2018

Recent advances in single atom catalysts and their applications in organic chemistry are fully summarized in this review.
Revisit of layered sodium manganese oxides: achievement of high energy by Ni incorporation
Authors: Konarov Aishuak , Choi Ji Ung , Bakenov Zhumabay , Myung Seung-Taek
Published: April 2018

Ni incorporation into Na2/3MnO2 suppresses the cooperative Jahn–Teller distortion and leads to a P2–O2 phase transition with about 13% of volume change.
A novel mitochondria-targeted rhodamine analogue for the detection of viscosity changes in living cells, zebra fish and living mice
Authors: Guo Rui , Yin Junling , Ma Yanyan , Wang Qiuan , Lin Weiying
Published: April 2018

We designed a novel mitochondria-targeted rhodamine analogue for the detection of viscosity changes in living cells, zebra fish, and living mice.
Elucidating the key role of fluorine in improving the charge mobility of electron acceptors for non-fullerene organic solar cells by multiscale simulations
Authors: Yao Chuang , Peng Cheng , Yang Yezi , Li Lei , Bo Maolin , Wang Jinshan
Published: April 2018

F–π interactions play a key role in improving the electron mobility of fluorinated electron acceptors for non-fullerene OSCs.
Does the Visual Channel Improve the Perception of Consonants Produced by Speakers of French With Down Syndrome?
Authors: Hennequin Alexandre , Rochet-Capellan Amélie , Gerber Silvain , Dohen Marion
Published: April 2018

Purpose

This work evaluates whether seeing the speaker's face could improve the speech intelligibility of adults with Down syndrome (DS). This is not straightforward because DS induces a number of anatomical and motor anomalies affecting the orofacial zone.

Method

A speech-in-noise perception test was used to evaluate the intelligibility of 16 consonants (Cs) produced in a vowel–consonant–vowel context (Vo = /a/) by 4 speakers with DS and 4 control speakers. Forty-eight naïve participants were asked to identify the stimuli in 3 modalities: auditory (A), visual (V), and auditory–visual (AV). The probability of correct responses was analyzed, as well as AV gain, confusions, and transmitted information as a function of modality and phonetic features.

Results

The probability of correct response follows the trend AV > A > V, with smaller values for the DS than the control speakers in A and AV but not in V. This trend depended on the C: the V information particularly improved the transmission of place of articulation and to a lesser extent of manner, whereas voicing remained specifically altered in DS.

Conclusions

The results suggest that the V information is intact in the speech of people with DS and improves the perception of some phonetic features in Cs in a similar way as for control speakers. This result has implications for further studies, rehabilitation protocols, and specific training of caregivers.

Supplemental Material

https://doi.org/10.23641/asha.6002267
Understanding perception of active noise control system through multichannel EEG analysis
Authors: Bagha Sangeeta , Tripathy R.K. , Nanda Pranati , Preetam C. , Das Debi Prasad
Published: April 2018

In this Letter, a method is proposed to investigate the effect of noise with and without active noise control (ANC) on multichannel electroencephalogram (EEG) signal. The multichannel EEG signal is recorded during different listening conditions such as silent, music, noise, ANC with background noise and ANC with both background noise and music. The multiscale analysis of EEG signal of each channel is performed using the discrete wavelet transform. The multivariate multiscale matrices are formulated based on the sub‐band signals of each EEG channel. The singular value decomposition is applied to the multivariate matrices of multichannel EEG at significant scales. The singular value features at significant scales and the extreme learning machine classifier with three different activation functions are used for classification of multichannel EEG signal. The experimental results demonstrate that, for ANC with noise and ANC with noise and music classes, the proposed method has sensitivity values of 75.831% () and 99.31% (), respectively. The method has an accuracy value of 83.22% for the classification of EEG signal with music and ANC with music as stimuli. The important finding of this study is that by the introduction of ANC, music can be better perceived by the human brain.
AC flashover performance of different shed configurations of composite insulators under fan‐shaped non‐uniform pollution
Authors: Zhang Zhijin , Qiao Xinhan , Zhang Yi , Tian Liang , Zhang Dongdong , Jiang Xingliang
Published: April 2018

Currently, it is founded that under unidirectional wind and certain landform, composite insulators are always fan‐shaped non‐uniformly polluted. In this paper, artificial pollution tests on three types of composite insulators with different shed configurations and under various fan‐shaped non‐uniform pollution conditions were carried out. Then the flashover performances of composite insulators, porcelain insulators and glass insulators were compared. Results indicate that there is a big difference between ac flashover performance of composite insulators under non‐uninform pollution and uninform pollution. The flashover voltage of composite insulator is largely influenced by salt deposit density (SDD), the ratio of SDD of windward side to leeward side (W/L), the occupation ratio of leeward side k and the shed configurations. The relationship between SDD and U50 still meets negative power function when composite insulator is fan‐shaped non‐uninform polluted. There is a reduction of 17.8–27.6% in the flashover strength when the ratio W/L of SDD decreases from 1/1 to 1/15. The shed configurations of composite insulators have great effects on the flashover performance. Composite insulators always have better withstand property compared to glass and porcelain insulators under either uniform pollution or fan‐shaped non‐uniform pollution.
Practical time‐varying formation tracking for multiple non‐holonomic mobile robot systems based on the distributed extended state observers
Authors: Yu Jianglong , Dong Xiwang , Li Qingdong , Ren Zhang
Published: April 2018

Practical time‐varying formation tracking analysis and design problems for multiple non‐holonomic mobile robot systems with directed interaction topologies are investigated by using the distributed extended state observers, where the practical time‐varying formation tracking error is controlled within an arbitrary small bound. Different from the previous work, the dynamics of each robot is non‐holonomic and the followers are required to form the practical time‐varying formation with respect to the leader of unknown control inputs. Besides, the disturbances and the uncertainties are considered in the dynamic model of the follower. Distributed extended state observers are constructed by using only the neighbouring relative information to estimate both the state and the unknown control inputs of the leader simultaneously. A practical time‐varying formation tracking protocol is presented based on the distributed extended state observers. The gain matrices of the observers in the practical time‐varying formation tracking protocol can be obtained by solving three linear matrix inequalities. Moreover, the stability of the multiple non‐holonomic mobile robot system under the proposed protocol is proved by using the properties of the Laplacian matrix and the Lyapunov stability theory. Finally, two numerical simulation examples are given to illustrate the effectiveness of the obtained theoretical results.
High‐level feature aggregation for fine‐grained architectural floor plan retrieval
Authors: Sharma Divya , Chattopadhyay Chiranjoy
Published: April 2018

Due to the massive growth of real estate industry, there is an increase in the number of online platforms designed for finding homes/furnished properties. Instead of descriptive words, query by example is always a preferred method for retrieval. Floor plans are the basic 2D representation giving an idea about the building structure at a particular level. The authors propose a framework for the retrieval of similar architectural floor plans under the query by example paradigm. They propose a novel algorithm to extract high‐level semantic features from an architectural floor plan. Fine‐grained retrieval using weighted sum of the features is proposed, where a feature can be given more preference over others, during retrieval. Experiments were performed on publicly available dataset containing 510 floor plans and compared with existing state‐of‐the‐art techniques. Their proposed method outperforms others both in qualitative and quantitative terms.
Performance evaluation of integrated strategy of vehicle route guidance and traffic signal control using traffic simulation
Authors: Yu Hao , Liu Pan , Ma Rui , Bai Lu
Published: April 2018

This study evaluated the integrated strategy performance of vehicle route guidance and traffic signal control methods using traffic simulation. Based on the proposed optimal framework, three typical traffic signal control methods, including fixed signal control, actuated signal control, and regional coordinative signal control, were investigated via plugin applications, integrated with vehicle route guidance. The characteristics of vehicle route guidance approaches were captured using different guidance information updating frequencies and different user compliance rates. The average link occupancy was used as a representation of the network traffic states, and the network performance was measured by the total travel time. A total of 12,480 simulation runs were conducted. Based on the regression results, six integrated strategies were selected into a recommended integration strategy set. The transferability test shows that the performance of the integration strategy set is quite consistent.
Bandpass filters using multi‐mode square ring resonators
Authors: Zhang Jinli , He Ming , Chen Haihua , Pang Doudou , Ji Lu , Zhao Xinjie , Zhang Xu
Published: April 2018

A novel scheme of a multi‐mode square ring resonator (MMSRR) is proposed in this study. To analyse the characteristics of the proposed resonator, the odd‐ and even‐mode based method is used, which shows that the basic type of resonator has five resonant modes and three transmission zeros (TZs). The frequencies of the transmission poles and TZs can be changed by varying the sizes of the transmission lines of the resonator flexibly. By varying properly the parameters of the resonator, a dual‐band bandpass filter (BPF) is designed with central frequencies of 1.78 and 3.04 GHz, respectively. To explore further the performance of the proposed MMSRR, two single‐band BPFs with controllable bandwidth are designed. The bandwidth of the filter can be tuned in the range of 138.6 MHz by changing only the characteristic impedance of middle microstrips, which is much higher than previous works. Furthermore, to improve the band‐to‐band isolation of dual‐band filters, a stub is imposed in the middle of the proposed resonator, which can improve significantly the band‐to‐band isolation. Simulation and measurement results show that the isolation is >26.3 dB. The results of the simulation and measurement are in good agreement.
Two‐stage glowworm swarm optimisation for economical operation of hydropower station
Authors: Wang Xiaoyu , Yang Kan , Zhou Xianghua
Published: April 2018

This study proposes a two‐stage glowworm swarm optimisation (GSO) algorithm for the economical operation of the inner plant of a hydropower station. Binary GSO and real‐coded GSO (RCGSO) algorithms are applied with different types of encodings to solve the unit commitment sub‐problem and the economic load distribution (ELD) sub‐problem, respectively. Moreover, an improved dynamic patching mechanism is developed to avoid invalid calculations and enrich the diversity of the solutions. A luciferin transfer mechanism helps the algorithm escape the local optimum and a local research mechanism enhances the diversity of the solution space by selecting from among the derived solutions. The RCGSO algorithm uses a variable‐step mechanism to avoid missing the optimal solution. In comparison with the genetic algorithm and particle swarm optimisation, the RCGSO is significantly robust and provides better solutions to ELD sub‐problems. Numerical simulations exhibited the superiority of the two‐stage GSO algorithm in terms of stably and quickly solving the economical operation problem of hydropower stations.
Systematic search for tidal features around nearby galaxies
Authors: Morales Gustavo , Martínez-Delgado David , Grebel Eva K. , Cooper Andrew P. , Javanmardi Behnam , Miskolczi Arpad
Published: April 2018

Context. In hierarchical models of galaxy formation, stellar tidal streams are expected around most, if not all, galaxies. Although these features may provide useful diagnostics of the Λ CDM model, their observational properties remain poorly constrained because they are challenging to detect and interpret and have been studied in detail for only a sparse sampling of galaxy population. More quantitative, systematic approaches are required. We advocate statistical analysis of the counts and properties of such features in archival wide-field imaging surveys for a direct comparison against results from numerical simulations. Aims. We aim to study systematically the frequency of occurrence and other observational properties of tidal features around nearby galaxies. The sample we construct will act as a foundational dataset for statistical comparison with cosmological models of galaxy formation.

Methods. Our approach is based on a visual classification of diffuse features around a volume-limited sample of nearby galaxies, using a post-processing of Sloan Digital Syk Survey (SDSS) imaging optimized for the detection of stellar structure with low surface brightness.

Results. At a limiting surface brightness of 28 mag arcsec−2, 14% of the galaxies in our sample exhibit evidence of diffuse features likely to have arisen from minor merging events. Our technique recovers all previously known streams in our sample and yields a number of new candidates. Consistent with previous studies, coherent arc-like features and shells are the most common type of tidal structures found in this study. We conclude that although some detections are ambiguous and could be corroborated or refuted with deeper imaging, our technique provides a reliable foundation for the statistical analysis of diffuse circumgalactic features in wide-area imaging surveys, and for the identification of targets for follow-up studies.
Estimating activity cycles with probabilistic methods
Authors: Olspert N. , Pelt J. , Käpylä M. J. , Lehtinen J.
Published: April 2018

Context. Period estimation is one of the central topics in astronomical time series analysis, in which data is often unevenly sampled. Studies of stellar magnetic cycles are especially challenging, as the periods expected in those cases are approximately the same length as the datasets themselves. The datasets often contain trends, the origin of which is either a real long-term cycle or an instrumental effect. But these effects cannot be reliably separated, while they can lead to erroneous period determinations if not properly handled.

Aims. In this study we aim at developing a method that can handle the trends properly. By performing an extensive set of testing, we show that this is the optimal procedure when contrasted with methods that do not include the trend directly in the model. The effect of the form of the noise (whether constant or heteroscedastic) on the results is also investigated.

Methods. We introduced a Bayesian generalised Lomb-Scargle periodogram with trend (BGLST), which is a probabilistic linear regression model using Gaussian priors for the coefficients of the fit and a uniform prior for the frequency parameter.

Results. We show, using synthetic data, that when there is no prior information on whether and to what extent the true model of the data contains a linear trend, the introduced BGLST method is preferable to the methods that either detrend the data or opt not to detrend the data before fitting the periodic model. Whether to use noise with other than constant variance in the model depends on the density of the data sampling and on the true noise type of the process.
Recent advances in utilization of flaxseed as potential source for value addition
Authors: Kaur Parvinder , Waghmare Roji , Kumar Vikas , Rasane Prasad , Kaur Sawinder , Gat Yogesh
Published: April 2018

Flax seed (Linum usitatissimum) is an important oilseed crop which has gained importance since last few decades due to its unique nutrient profile. Flax seed comprises high amount of fiber and is a significant source of α-linolenic acid in the diet of vegetarian people. It is evident from several studies conducted that flaxseed carries functional ingredients and provide health benefits. Omega-3 fatty acid, lignan and dietary fiber are major bioactive components of flaxseed which can be delivered through value added products. Flax seed has been successfully exploited in preparation of various value added products. Commercially, all parts of flaxseed plant are exploited directly or after processing. Flaxseed consumption in the diet prevents serious diseases like coronary diseases, cancer, diabetes, obesity, gastrointestinal, renal and bone disorders. To the best of our knowledge, very limited review reports are available for commercial utilization of flaxseed in preparation of various value added products (bakery, dairy, extruded, snack, fermented and other traditional) and effect of flaxseed fortification on nutritional, physicochemical, phytochemical and sensory properties of these products. In future, this data could be useful for different food processing industries.
Editorial
Authors: Schuch Florian
Published: April 2018

Liebe Kolleginnen und Kollegen,

ein ausgesprochen spannendes, abwechslungsreiches und gut lesbares Heft „Aktuelle Rheumatologie“ liegt vor Ihnen. Die Rheumatologie und rheumatologische Differenzialdiagnostik ist und bleibt bunt, vielfältig und überraschend.
Validierung der deutschen Version des Eating Assessment Tool bei Kopf-Hals-Tumor-Patienten
Authors: Zaretsky Eugen , Steinbach-Hundt Silke , Pluschinski Petra , Grethel Isabel , Hey Christiane
Published: April 2018

Hintergrund Die Erfassung von subjektiv empfundenen Schluckbeschwerden bildet ein wichtiges Element in einem multidimensionalen und damit modernen
Management von schluckgestörten Patienten infolge eines Kopf-Hals-Tumors. Zur Verfügung steht hier der international anerkannte und validierte
10-Item-Fragebogen EAT-10, der 2008 von Belafsky et al. entwickelt und validiert wurde. Ziel der vorliegenden Studie ist die Übersetzung des EAT-10 in die
deutsche Sprache und dessen Validierung für Patienten mit einem Kopf-Hals-Tumor.

Material und Methoden Nach Übersetzung des EAT-10 ins Deutsche gemäß den Richtlinien zur Übersetzung fremdsprachlicher Messinstrumente erfolgte die
Validierung des gEAT-10 anhand von 210 Kopf-Hals-Tumor-Patienten. Ermittelt wurden die Reliabilität anhand der internen Konsistenz (Cronbachs Alpha) und
Eigentrennschärfe (Spearman-Korrelation). Die Konstruktvalidität wurde geprüft anhand der uni- und multivariaten Berechnung der Verteilung von
gEAT-10-Gesamtscores abhängig von Geschlecht, Alter, BMI, Tumorstadium und -lokalisation sowie der Art der onkologischen Therapie.

Ergebnisse Die interne Konsistenz betrug α = 0,94. Die Eigentrennschärfe variierte zwischen ρ = 0,59 und ρ = 0,85. Es ließ sich kein signifikanter
Zusammenhang zwischen gEAT-10-Gesamtscore und Geschlecht bzw. Alter univariat erkennen, jedoch einer für BMI, Tumorstadium und -lokalisation sowie Art der
onkologischen Therapie. In der Regression lieferte dagegen nur das Tumorstadium ein signifikantes Ergebnis.

Schlussfolgerung Der gEAT-10 erwies sich als ein reliabler und konstruktvalider Fragebogen zur Erfassung subjektiver Schluckbeschwerden bei Patienten mit
Kopf-Hals-Tumor.
Convergent Synthesis of Novel Mono- and Di-substituted 1,2-Isopropylideneglucofuranose Appended Dendrimers with a Ferrocene Core and their Electrochemical Studies
Authors: Ray Ankur , Khan Sabiha
Published: April 2018

Ferrocene-cored dendrimers incorporating 1,2-isopropylidenefuranose capped furanoside branches were synthesized and their electrochemical properties were studied. It was observed that the dendritic environment in the ferrocene dendrimers increased the E
1/2 values with increase in bulk of the dendrimer, as expected. The reversible nature of the redox process was maintained in all the dendrimers.
Intraoperative Fluorescence Is Useful but Not Always Sufficient in Contrast-Enhancing Malignant Gliomas
Authors: Moiyadi Aliasgar
Published: April 2018

Fluorescence-guided resections have become standard of care for malignant gliomas. Strong fluorescence has been shown to correlate with solid enhancing tumor. However, with experience it has also been shown that visualized fluorescence may not identify the entire extent of the tumor. Knowing that malignant gliomas extend beyond the contrast-enhancing tumor seen on magnetic resonance imaging (MRI), reliance only on the fluorescence intraoperatively may not be enough. Intraoperative ultrasound is a readily available tool for real-time assessment of resection status, irrespective of the tumor type. We describe one such case in which after resecting all the visible fluorescing tumor component, we identified a significant component of nonfluorescing tumor, using intraoperative ultrasound that was further resected completely. This illustrates the need for multimodal intraoperative guidance for achieving optimal tumor resection in malignant gliomas.
Osteoma osteoide, causa inusual de dolor de muñeca
Authors: Beteta Robles Teresa , Olea Angel , Blanco Luz
Published: April 2018

Presentamos el caso de una mujer joven con dolor en muñeca de meses de evolución. Las pruebas de imagen que se le realizan no son concluyentes. La clínica nos hace sospechar en el OO como posible diagnostico por lo que se realiza una TC que pone de manifiesto la presencia del nidus. Siguiendo el protocolo de nuestro servicio, se decide como tratamiento la ablación percutánea por radiofrecuencia. La mejoría clínica es inmediata. Aunque la mayoría de los OO son de diagnóstico sencillo, siguen presentándose algunos casos, como el del paciente expuesto, cuyas localizaciones peculiares o tamaño pequeño pueden producir errores o retrasos en el diagnostico.
Relationship between In Vitro Fertilization and Neonatal Outcomes in Very Low Birth Weight Preterm Infants
Authors: Al-Hathlol Khalid
Published: April 2018

Objective To assess the association of in vitro fertilization (IVF) with neonatal outcomes and duration of stay in neonatal intensive care unit (NICU) among very low birth weight (VLBW) preterm infants.

Methods This was a cohort study of VLBW preterm infants admitted to NICU over 15 years. We assessed neonatal outcomes including composite outcome of mortality or severe morbidity, risk for major birth defects, survival without severe morbidity, and the duration of NICU stay across three birth-year epochs.

Results A total of 1,533 infants were eligible for data analysis. Of these, 236 were born following IVF and 1,297 were born following spontaneous conception (SC). After adjustment for baseline variables, regression analysis revealed no statistically significant differences between IVF and SC groups in terms of the composite outcome of mortality or severe morbidity, risk for major birth defects, survival without severe morbidity, or duration of NICU stay.

Conclusion Among VLBW preterm infants, IVF had no detectable relationship with neonatal outcomes and duration of NICU stay. These findings can help provide guidance in professional counseling of affected families.
Radiologisch basierte Therapie des Kehlkopfkrebses überprüft
Authors: Büntzel Jens
Published: April 2018

Ko HC et al. Survival Outcomes for Patients With T3N0M0 Squamous Cell Carcinoma of the Glottic Larynx. JAMA Otolaryngol Head Neck Surg 2017; 143: 1126–1133

Wie ist das Überleben von Patienten mit Kehlkopfkrebs im Stadium T3N0M0, die operativ oder mittels Radiotherapie behandelt wurden? Zur Klärung dieser Frage
verglichen chinesische Wissenschaftler die retrospektiven Daten dieser Patienten über einen langfristigen Nachbeobachtungszeitraum.
What can we learn from untapped wildlife rescue databases? The masked lapwing as a case study
Authors: Pyke Graham H. , Szabo Judit K.
Published: April 2018

Much untapped potential exists for research based on wildlife rescues and surveys by citizen scientists. Many vertebrate animals are injured or threatened with injury through human activities and warrant ‘rescue’, generally by volunteers. Faunal surveys, involving citizen scientists, yield complementary biologically relevant information. Research using these databases can indicate spatial and temporal patterns in abundance and risk of mishap, potentially informing management and conservation for threatened species. However, little research has utilised such databases, with few implications for conservation, leaving a wealth of available information. We used the masked lapwing (Vanellus miles), an Australian shorebird, to illustrate the research potential of a rescue database combined with bird survey data. This species nests and feeds on the ground, has flightless young dependent on parents for protection, and is commonly observed in urban and agricultural areas. Consequently, it is often recorded during bird surveys and is frequently rescued. Combining rescue information with abundance estimates from bird surveys should confirm or refine knowledge about abundance and reproductive biology, and indicate spatio-temporal patterns in the risks encountered. To evaluate these expectations, we obtained date, location and age for lapwings rescued by NSW Wildlife Information Research and Education Service during 2005–2013, and monthly reporting rates from New Atlas of Australian Birds during 1999–2010. Numbers of rescued lapwing chicks, juveniles and adults per month were consistent with the life cycle of this species, and risks from vehicles, pets and other human activities. Our results illustrate how research utilising rescue and fauna survey databases could inform management and conservation of threatened species.
How just and just how? A systematic review of social equity in conservation research
Authors: Friedman Rachel S , Law Elizabeth A , Bennett Nathan J , Ives Christopher D , Thorn Jessica P R , Wilson Kerrie A
Published: April 2018

Background: Conservation decisions not only impact wildlife, habitat, and environmental health, but also human wellbeing and social justice. The inclusion of safeguards and equity considerations in the conservation field has increasingly garnered attention in international policy processes and amongst conservation practitioners. Yet, what constitutes an ‘equitable’ solution can take many forms, and how the concept is treated within conservation research is not standardized. This review explores how social equity is conceptualized and assessed in conservation research.

Methods/Design: Using a structured search and screening process, we identified 138 peer-reviewed studies that addressed equity in relation to conservation actions. The authors developed a coding framework to guide the review process, focusing on the current state of, definitions used for, and means of assessing social equity in empirical conservation research.

Review Results: Results show that empirical research on social equity in conservation is rapidly growing, with the majority of studies on the topic published only since 2009. Equity within conservation research is skewed toward distributional concerns and to a lesser extent procedural issues, with recognition and contextual equity receiving little attention. Studies are primarily situated in forested biomes of the Global South. Conservation interventions mostly resulted in mixed or negative impacts on equity.

Synthesis and Discussion: Our results demonstrate the current limitations of research on equity in conservation, and raise challenging questions about the social impacts of conservation and how to ameliorate equity concerns. Framing of equity within conservation research would benefit from greater transparency of study motivation, more explicit definition of how equity is used within the study context, and consideration for how best to assess it. We recommend that the empirical conservation literature more deeply engage with different notions of equity when studying, planning, and implementing actions to address potential trade-offs among equity and conservation objectives and beneficiaries.
Parametric Investigation on Microstructure and Mechanical Properties of Ultrasonic spot welded Aluminium to Copper sheets
Authors: Satpathy Mantra Prasad , Das Mohapatra Kasinath , Sahoo Ananda Kumar , Sahoo Susanta Kumar
Published: April 2018

Ultrasonic welding is one of the promising solid state welding methods which have been widely used to join highly conductive materials like aluminum and copper. Despite these applications in the automotive field, other industries also have a strong interest to adopt this process for joining of various advanced alloys. In some of its applications, poor weld strength and sticking of the workpiece to the tool are issues. Thus, an attempt has been taken in the present study to overcome these issues by performing experiments with a suitable range of weld parameters. The major objectives of this study are to obtain a good joint strength with a reduced sticking phenomenon and microstructure of Al-Cu weld coupons. The results uncovered the mechanical strength of the joint increased up to 0.34 sec of weld time and afterward, it gradually decreased. Meantime, the plastic deformation in the weld zone enhanced the formation of an intermetallic layer of 1.5 μm thick, and it is composed of mainly Al2Cu compound. The temperature evolved during the welding process is also measured by thermocouples to show its relationship with the plastic deformation. The present work exemplifies a finer understanding of the failure behavior of joints and provides an insight of ultrasonic welding towards the improvement in the quality of weld.
RWEN: response-weighted elastic net for prediction of chemosensitivity of cancer cell lines
Authors: Basu Amrita , Mitra Ritwik , Liu Han , Schreiber Stuart L , Clemons Paul A
Published: April 2018

Motivation

In recent years there have been several efforts to generate sensitivity profiles of collections of genomically characterized cell lines to panels of candidate therapeutic compounds. These data provide the basis for the development of in silico models of sensitivity based on cellular, genetic, or expression biomarkers of cancer cells. However, a remaining challenge is an efficient way to identify accurate sets of biomarkers to validate. To address this challenge, we developed methodology using gene-expression profiles of human cancer cell lines to predict the responses of these cell lines to a panel of compounds.

Results

We developed an iterative weighting scheme which, when applied to elastic net, a regularized regression method, significantly improves the overall accuracy of predictions, particularly in the highly sensitive response region. In addition to application of these methods to actual chemical sensitivity data, we investigated the effects of sample size, number of features, model sparsity, signal-to-noise ratio, and feature correlation on predictive performance using a simulation framework, particularly for situations where the number of covariates is much larger than sample size. While our method aims to be useful in therapeutic discovery and understanding of the basic mechanisms of action of drugs and their targets, it is generally applicable in any domain where predictions of extreme responses are of highest importance.

Availability and implementation

The iterative and other weighting algorithms were implemented in R. The code is available at https://github.com/kiwtir/RWEN. The CTRP data are available at ftp://caftpd.nci.nih.gov/pub/OCG-DCC/CTD2/Broad/CTRPv2.1_2016_pub_NatChemBiol_12_109/ and the Sanger data at ftp://ftp.sanger.ac.uk/pub/project/cancerrxgene/releases/release-6.0/.

Supplementary information

Supplementary data are available at Bioinformatics online.
Do women in Europe live longer and happier lives than men?
Authors: Solé-Auró Aïda , Jasilionis Domantas , Li Peng , Oksuzyan Anna
Published: April 2018

Background

The article examines gender differences in happy life expectancy at age 50 (LE50) and computes the age-specific contributions of mortality and happiness effects to gender differences in happy LE50 in 16 European countries.

Methods

Abridged life tables and happy LE50 were calculated using conventional life tables and Sullivan’s method. Age-specific death rates were calculated from deaths and population exposures in the Human Mortality Database. Happiness prevalence was estimated using the 2010–11 Survey of Health, Ageing and Retirement in Europe. Happiness was defined using a single question about life satisfaction on a scale of 0–10. A decomposition algorithm was applied to estimate the exact contributions of the differences in mortality and happiness to the overall gender gap in happy LE50.

Results

Gender differences in happy LE50 favour women in all countries except Portugal (0.43 years in Italy and 3.55 years in Slovenia). Generally, the contribution of the gender gap in happiness prevalence is smaller than the one in mortality. The male advantage in the prevalence of happiness partially offsets the effects of the female advantage in mortality on the total gender gap in happy LE50. Gender differences in unhappy life years make up the greatest share of the gender gap in total LE50 in all countries except Denmark, Germany, Netherlands, Slovenia and Sweden.

Conclusion

Countries with the largest gender gap in LE are not necessarily the countries with larger differences in happy LE50. The remaining years of life of women are expected to be spent not only in unhealthy but also in unhappy state.