bluuebunny/crossref_metadata_2025 huggingface dataset:
How workplace discipline, transformational leadership, and career development affect employee performance at the Royal Beach Hotel Seminyak Bali
Authors: Sukmana Iwk Teja , Pertiwi Ni Putu Adella Tika , Sirna I Ketut , Sulistiyo Eko , Susanto Putu Chris
Published: February 2022

This study examines the impact of workplace discipline, transformational leadership, and career development on employee performance at a five-star hotel in Bali. The study was conducted at the Royal Beach Seminyak Bali, which is a part of Accor Group’s MGallery Collection of boutique hotels. The data was collected from 73 employees who were selected using a randomized sampling method using a close-ended questionnaire, which was then analyzed quantitatively using regression analysis. The results suggest that workplace discipline, transformational leadership, and career development positively affect employee performance (sig. of 0.038; 0.032; and 0.028 respectively [α < 0.05]). Meanwhile, the study also indicates that workplace discipline, transformational leadership, and career development simultaneously have positive effect on employee performance (F-count = 31.702, greater than F-table = 2.74, α < 0.01). This suggests that improvement in workplace discipline, transformational leadership, and career development, could positively affect employee performance at The Royal Beach Seminyak Bali. 
Women empowerment through local wisdom as production differentiation strategy
Authors: Komalasari Yeyen , Suryantari Eka Putri , Marhaendra Tjokorda Bagus Putra
Published: February 2022

This article explores the application of production differentiation strategy by women empowerment through local wisdom of Nasi Koco in the herritage area, Gajah Mada Street, Denpasar-Bali. The purpose of this article is to increase the sales of Nasi Koco by implementing new strategies to win the competition in similar businesses that have sprung up. The strategy that can be offered is a product differentiation, so that the product is more varied and not monotonous, that attracts consumer interest. The product differentiation strategy offered refers more to women's empowerment through local wisdom, namely making products or food variations needed for ceremonies, where as we know people's lives in Bali are full of a series of religious ceremonies. The study employed qualitative approaches using narrative research by observation, interview, and documentation. The result of the study base on an in-depth interview with Balinese women who understand Balinese traditional culture, the advice that can be given is to make product variations, not just Nasi Jinggo or Nasi Wrap as usual, but to make it more varied. Suggested variations are Nasi Tumpeng, Nasi Yasa, and Nasi Kelangi, which are usually used for traditional activities in Bali.
Employee performance review of servant leadership and organizational commitment at the Samaya Seminyak Bali Hotel
Authors: Sirna I Ketut , Saputri Ni Putu Budihari , Tingkes I Nyoman
Published: February 2022

This study aims to determine partially and simultaneously servant leadership and organizational commitment to employee performance at The Samaya Seminyak Bali. Proportional Random Sampling method, the number of samples is 51 employees. Data analysis using Validity Test, Reliability Test, Partial Correlation Analysis, Multiple Correlation Analysis, Multiple Linear Regression Analysis, Coefficient of Determination Test, the research shows that (1) servant leadership has a positive and significant effect on employee performance, with the results of regression analysis of X1 = 0.295, (2) organizational commitment has a positive and significant effect on employee performance, with the results of regression analysis of X2 = 0.593, (3) simultaneously servant leadership and organizational commitment have a positive and significant effect on employee performance, obtained multiple linear regression analysis of Y = 12.251+0.295X1+0.593X2, and the coefficient of determination shows 21.3%. Based on these results, it can be concluded that servant leadership and organizational commitment are very influential partially and simultaneously on employee performance at The Samaya Seminyak Bali.
BLOCKCHAIN: NEW ECONOMIC AND MANAGEMENT SOLUTIONS IN ART INDUSTRY
Authors: Pichuhina Yu.
Published: February 2022

The article actualizes the importance of the blockchain in economic and managerial processes in the art market. The purpose of the article is to determine the effectiveness of blockchain technologies in relation to economic and managerial processes in the art industry, based on real recent examples. The key innovative qualities of the blockchain register in the art industry have been clarified. The context of the study is narrowed to digital art, in which the final art product is often completely devoid of any physical forms. Its implementation takes place exclusively in the digital space, which at the same time indicates the dematerialization of digital art outside it. Therefore, the advantages of blockchain technology in art economic are best revealed here, in the market of dematerialized goods and wallets.
Recent examples of the conversion of fine art works to NFT (Banksy "Morons (White)", Mike Winkelman "Everydays: The first 5000 Days") are studied. They brought us closer to understanding the effectiveness of blockchain technology in the art industry. In the study, we turned to the origins of NFT, recalling the first blockchain game CryptoKitties (developed by AxiomZen), in the context of which all the conditions were created for the deployment of the digital art industry in its current form. The influence of blockchain on changes in the organizational work of traditional art sellers, including auction houses, galleries, dealers is considered. In 2021, Christie’s auction was the first in the history of the traditional art market to put up for sale a lot of digital artwork, thus showing that the canonical subjects of the art market are ready for new challenges. The new subject of commodity-money relations in the modern art market - art marketplaces - is outlined. In the context of the national segment of the art market a multifunctional online platform V-Art is considered. It provides opportunities for all actors in the modern art market. The further perspectives of this research are outlined, which may be related to the analysis of the buyer of digital art works, who is it and why it does it, because the work of digital art has limited functionality compared to traditional physical works of art.
Influence of Cultural Dimensions on Intercultural Communication Styles: Ethnicity in a Moderating Role
Authors: Balakrishnan Kavitha
Published: February 2022

In a culturally varied context where managing and coordinating communication with people from various backgrounds is the greatest challenge, effective intercultural communication is even more important. It is critical for professionals and practitioners to comprehend the nuances and complexity of communication and develop competencies in this area. As a result, the importance of intercultural communication styles cannot be more emphasised, as it is a critical component of the current global and dynamic phenomenon in Malaysian workplaces. However, studies in this field are scarce, particularly in a multicultural country like Malaysia. The interaction between the determinants of cultural dimensions on intercultural communication styles variables among employees in Malaysian workplaces from various cultures and social demography is investigated in this study. The data analysis will be undertaken using SMART-PLS for generating the structural equation modelling employing data obtained from 400 practitioners via a self-administered survey questionnaire. The probability sampling technique of simple random sampling will be used for data analysis. The findings will provide insight into industry expectations and the professional skills needed to equip them for careers in typical culturally diverse situations. The findings will reveal if cultural dimension factors have a direct and statistically significant impact on intercultural communication styles. Theoretical and practical significance on the stakeholders is discussed.
The person-based development and realist evaluation of a summary report for GP consultations
Authors: Murphy Mairead , Wong Geoff , Scott Anne , Wilson Victoria , Salisbury Chris
Published: February 2022

Background:Use of telephone, video and e-consultations is increasing. These can make consultations more transactional. This study aimed to develop a complex intervention to address patients’ concerns more comprehensively in general practice and test the feasibility of this in a cluster-randomised framework.

The complex intervention used two technologies:a patient-completed pre-consultation form used at consultation opening and a doctor-provided summary report provided at consultation closure. This paper reports on the development and realist evaluation of the summary report.

Methods:A person-based approach was used to develop the summary report. An electronic protocol was designed to automatically generate the report after GPs complete a clinical template in the patient record. This was tested with 45 patients in 3 rounds each, with iterative adjustments made based on feedback after each round.

Subsequently, an intervention incorporating the pre-consultation form with the summary report was then tested in a cluster-randomised framework with 30 patients per practice in six practices: four randomised to intervention, and two to control. An embedded realist evaluation was carried out. The main feasibility study results are reported elsewhere.

Results:Intervention Development: 15 patients were recruited per practice. Eight patients and six GPs were interviewed and 18 changes made. The summary report improved substantially; GPs and patients in the final practice were more satisfied with the report than the first practice.

Realist evaluation: The summary was most useful for consultations when safety-netting advice was important or with multiple complex follow-up steps in patients who have difficulty remembering or communicating. It generated greater clarity on the follow-up and greater patient empowerment and reassurance.

Conclusions:The person-based approach was successful. The summary report creates clarity, empowerment and reassurance in certain consultations and patients. As it takes a few minutes per patient, GPs prefer to select patients who will benefit most.
PENYUSUNAN PEDOMAN PEMANTAUAN DAN EVALUASI PERTANAHAN DI WILAYAH PESISIR, PULAU-PULAU KECIL DAN PULAU-PULAU KECIL TERLUAR DALAM UPAYA BELA NEGARA
Authors: Tasliman Michael Timothy
Published: February 2022

Indonesia merupakan salah satu negara yang menempati urutan kedua wilayah pantainya terpanjang di dunia dengan jumlah pulau menurut Kementerian Koordinator Bidang Kemaritiman dan Investasi IndonesiaÂ  mencapai 17.491 pulau dimana 111 pulau diantaranya ditetapkan sebagai pulau-pulau kecil terluar berdasarkan Keputusan Presiden Nomor 6 Tahun 2017. Hal ini tentu merupakan potensi yang cukup besar untuk mendorong pembangunan di negara ini. Kementerian Agraria dan Tata Ruang/Badan Pertanahan Nasional melalui Direktorat Jenderal Penataan Agraria telah melakukan inventarisasi penguasaan, pemilikan, penggunaan dan pemanfaatan tanah terhadap wilayah pesisir, pulau-pulau kecil dan pulau-pulau kecil terluar di Indonesia. Sebagai tindak lanjut dari kegiatan tersebut maka dibutuhkan langkah pemantauan dan evaluasi dari hasil inventarisasi sebagai upaya preventif timbulnya permasalahan pertanahan di kemudian hari dan terwujudnya tertib pertanahan. Atas dasar tersebut, maka Kementerian Agraria dan Tata Ruang/Badan Pertanahan Nasional melalui Direktorat Pengendalian Hak Tanah, Alih Fungsi Lahan, Kepulauan dan Wilayah Tertentu memiliki tugas untuk melaksanakan perumusan dan pelaksanaan kebijakan dan program, penyusunan norma, standar, prosedur, kriteria, pelaksanaan pengendalian, dan pemberian bimbingan teknis dan supervisi, serta pelaksanaan pemantauan, evaluasi dan pelaporan di bidang pengendalian hak tanah, alih fungsi lahan, kepulauan dan wilayah tertentu.
PROYEKSI KEBIJAKAN LUAR NEGERI AMERIKA SERIKAT ERA PEMERINTAHAN BIDEN DAN IMPLIKASINYA TERHADAP DIPLOMASI INDONESIA
Authors: Matondang Erlinda
Published: February 2022

Abstrak â€“ Terpilihnya Joe Biden sebagai Presiden ke-46 Amerika Serikat (AS) membawa babak baru dalam hubungan internasional. Sejumlah kebijakan baru sudah dirilis oleh Pemerintahan Biden walaupun untuk implementasinya mungkin akan berjalan secara efektif pada tahun 2022 atau saat masa transisi pemerintahan sudah berakhir. Dalam kebijakan luar negeri AS tersebut, tidak satu pun kawasan menjadi prioritas utama dan Pemerintahan Biden cenderung menunjukkan fokusnya dalam perbaikan kondisi domestik dan pemulihan kerja sama dengan beberapa entitas internasional. Sebagai salah satu negara maju dan besar di tataran internasional, perubahan kebijakan luar negeri AS juga berimplikasi terhadapIndonesia. Dengan netralitas dalam menanggapi perseteruan antara AS, Rusia, dan China, Indonesia mempunyai nilai dan posisi strategis dalam kebijakan luar negeri AS. Posisi strategis Indonesia dalam kebijakan luar negeri AS tidak hanya didorong oleh netralitasnya, tetapi juga peran aktifnya dalam berbagai forum internasional. Bahkan, Indonesia akan menyandang gelar pemimpin G20 pada 2022 dan ketua ASEAN pada 2023. Dengan gambaran situasi dan kondisi tersebut, penulis merekomendasikan kepada pemerintah Indonesia untuk tetap memelihara kerja sama yang sudah terjalin dengan AS sekaligus memantau perkembangan kebijakan luar negeri AS pasca-masa transisi pemerintahan. Bersamaan dengan itu, pemerintah Indonesia dapat memetakan dan merencanakan kerja sama bilateral, regional, dan multilateral dengan AS yang dapat dicapai pada masa kepemimpinannya di G20 pada tahun 2022 dan keketuaannya di ASEAN pada tahun 2023.Kata Kunci: diplomasi, kebijakan luar negeri, kerja sama bilateral, posisi strategis
PERANAN DISKUSI KELOMPOK DALAM PEMBELAJARAN TEMATIK TERHADAP PERILAKU AKADEMIK SISWA DI SD NEGERI KADUAGUNG KECAMATAN SINDANGAGUNG KABUPATEN KUNINGAN
Authors: Maharani Ade , Darkam Dede
Published: February 2022

Penelitian ini bertujuan untuk mengetahui perilaku akademik Siswa dalam diskusi kelompok Pembelajaran Tematik Di SD Negeri Kaduagung. Metode penelitian ini memakai metode penelitian deskriptif kualitatif. Lokasi penelitian bertempat di Sekolah Dasar Negeri Kaduagung Kecamatan Sindangagung Kabupaten Kuningan dengan subjek penelitian yaitu siswa kelas V yang berjumlah 38 orang siswa dan guru wali kelas V sebagai informan. Teknik pengumpulan data dan instrumen wawancara, observasi, dokumentasi dan angket. Berdasarkan hasil penelitian ini dapat diambil kesimpulan bahwa terdapat dampak positif dari pembelajaran diskusi kelompok terhadap perilaku akademik siswa kelas V di SD Negeri Kaduagung Kecamatan Sindangagung Kabupaten Kuningan. Guru berperan untuk meningkatkan kualitas perilaku akademik siswa dalam proses pembelajaran selama berada di sekolah. Sehingga disini guru sangat berperan dalam meningkatkan kualitas perilaku akademik siswa. Dengan demikian dapat disimpulkan bahwa Terdapat Dampak Yang Positif Dari Pembelajaran Diskusi Kelompok Terhadap Perilaku Akademik Siswa Kelas V di SD Negeri Kaduagung Kecamatan Sindangagung Kabupaten Kuningan.
Determinants of Short-Term Weight Gain Following Surgical Treatment for Craniopharyngioma in Adults
Authors: Hong A Ram , Kim Jung Hee , Park Seung Shin , Kong Sung Hye , Choi Hyung Jin , Kim Yong Hwy , Shin Chan Soo
Published: February 2022

Objective : Craniopharyngiomas (CPs) are associated with hypothalamic damage that causes hypothalamic obesity, however, the mechanisms underlying CP-related postoperative weight gain remain debatable. This study aimed to elucidate whether the major determinant of postoperative weight gain in patients with CP is hypothalamic injury or steroid replacement therapy.Methods : We included 48 adult patients with CP (age ≥18 years) who underwent transsphenoidal surgery between 2010 and 2018 in a single tertiary center, and whose body weight was measured pre- and postoperatively (<120 days after the surgery). We recruited 144 age- and body mass index-matched patients with non-functioning pituitary adenoma (NFPA) as controls.Results : Patients with CP experienced greater postoperative weight gain than patients with NFPA (3.0±5.1 vs. 0.1±3.6 kg, p<0.001). The prevalence of postoperative steroid use was significantly higher in patients with CP than in those with NFPA (89.6% vs. 34.0%, p<0.001). Steroid replacement therapy and CP were associated with postoperative weight gain after adjusting for covariates in overall patients (p=0.032 and 0.007, respectively). In subgroup analysis with postoperative steroid users, weight gain was significantly greater in patients with CP (n=43, 0.96±0.25 kg/month) than in patients with NFPA (n=49, 0.26±0.23 kg/month) even after adjusting for the daily steroid dose (p=0.048).Conclusion : Patients with CP experience greater postoperative weight gain than those with NFPA. Hypothalamic damage itself as well as steroid replacement may contribute to the postoperative weight gain in patients with CP.
The Social Media System in Cuba in Times of Change: A General Analysis
Authors: Ramírez Yarileisy Barcelay
Published: February 2022

The political arena in Cuba has had a direct impact on the development of the media throughout the country's history. Therefore, it is necessary to know the updated status of the Cuban media system in the last stage (2018-2019) nowadays. This article shows the main transformations of the Cuban media system, based on the analysis of the historical process experienced on the island since 1959. The current press model is classified based on the theoretical analysis of The Four Theories of the Press. The methodology used allowed us to carry out a study of 50 issues of the Granma newspaper - chosen for its great influence on the Cuban society, with a sample of 1031 news items on different topics. The analysis helped to determine that the content of the Cuban government media its core and main aims are used to spread the socialist ideas and concepts. Both the content analysis and the historical process revealed that the media in Cuba continues to be controlled by the Government and maintains its social character, which makes it possible to relate the current media system with the old Soviet press model, although the current scenario, marked by the access to Internet and the appearance of new independent digital media not recognized by the government, creates the bases for the conception of a socialist alternative to the social responsibility model.
Identificação precoce da sepse pela equipe de enfermagem em Unidades de Terapia Intensiva através dos sinais e sintomas: revisão narrativa
Authors: Brito Jhônata Santos , Passos Núbia Cristina Rocha , Dornelles Cristian , Aguiar Joycianne Ramos Vasconcelos de , Santos Ítalo Taveira dos , Santos Ianaê Gomes dos , Silva Julio Cesar Pereira da , Ramos Vitor Ferreira , Vieira Claudia Cristina Augusto Rodrigues , Batista Matheus Neres , Santos Emerson Galdino Rodrigues dos
Published: February 2022

A Sepse é definida como uma disfunção do organismo causada por uma resposta desregulada na infecção, em diferentes estágios clínicos de um mesmo processo fisiopatológico. O presente estudo teve como objetivo descrever quais os sinais e sintomas que antecedem a sepse os profissionais de enfermagem podem identificar de forma precoce em pacientes internados em Unidades de Terapia Intensiva – UTI’s. Metodologia: Trata-se de uma revisão narrativa da literatura fundamentada a partir de uma pesquisa bibliográfica a partir de uma pesquisa bibliográfica realizada em julho de 2020 nas respectivas fontes de dados: Medical Literature Analysis and Retrieval System Oline (Medline) e Scientific Electronic Library Online (SciELO). Resultados: O enfermeiropor trabalhar diretamente com o cuidado ao paciente beira-leito, tem a possibilidade de identificar as primeiras alterações clínicas dos sinais e sintomas que antecedem a sepse como por exemplo: taquicardia (88,5%), taquipnéia (79,2%), oligúria (78,1%), hipotermia (75,2%), hipotensão (67,1%), hipertermia (30,2%), dessaturação (12,7%), Rebaixamento do Nível de Consciência (RNC) (5,5%). Contudo, os profissionais de enfermagem tem certa dificuldade na identificação precoce da sepse na Unidade de Terapia Intensiva (UTI), seja pela complexidade que o paciente se encontra, falta de protocolo em algumas instituições ou até mesmo pela falta de conhecimento sobre este processo clínico.
Lodo de esgoto e suas potencialidades agrícolas
Authors: Araújo Vanessa dos Santos , Silva Mateus Oliveira , Brito André Seiva de , Sousa Iraneide de Lima , Nunes Françoyse Carvalho , Souza Juliana Fernanda Monteiro de , Oliveira Igor Vinicius de , Silva Claudete Rosa da , Carvalho Fábio Israel Martins , Silva José Nilton da , Silva Vicente Filho Alves , Silva Priscilla Andrade
Published: February 2022

O esgoto é constituído pela água usada nas atividades diárias, que foi usada para lavar roupa ou louça, no banho, na descarga do banheiro ou na pia. Esta água residual contém impurezas, constituída de uma mistura de detritos, restos de alimentos, detergentes, urina, fezes e outras substâncias. Quando jogado diretamente no meio ambiente, gera odor forte e fétido, além de conter bactérias nocivas, causadoras de enfermidades. Quando devidamente tratado, o lodo é chamado de biossólido, e sua reutilização agroflorestal pode ser uma alternativa atraente. Desse modo, o presente estudo tem como objetivo identificar o biossólido, caracterizar o processo de tratamento e a composição do material, relatar suas utilidades associadas a agricultura e recuperação de áreas degradadas, assim como normativas e legislações que vigoram a respeito desse resíduo. O trabalho foi conduzido por meio de levantamento bibliográfico que reúnem assuntos relevantes sobre o biossólido, características do biossólido, lodo de esgoto, utilização na agricultura, a fim de disponibilizar um conhecimento mais esclarecedor e relevante para a comunidade científica na área de tratamento de lodo de esgoto, convertendo-o em biossólido, sua caracterização e aplicação na agricultura nos mais variados aspectos.
Percepção dos consumidores sobre a aplicação de revestimentos comestíveis em carne bovina fresca
Authors: Nascimento Clarissa Pacheco Fernandes , Lopes Marcos Vinícius Aquino , Barbosa Kamila de Lima , Andrade Ana Paula Colares de , Oliveira Luciana de Siqueira , Eça Kaliana Sitonio
Published: February 2022

Esta pesquisa teve como objetivo fazer um levantamento sobre a percepção dos consumidores na utilização de revestimentos comestíveis (RC) em carne bovina fresca, como tecnologia de preservação, e sua influência na aquisição e nos hábitos de consumo desse produto. A coleta de dados ocorreu por meio de questionário online, divulgado através de mídias sociais no território nacional e respondido voluntariamente. Foram avaliadas 423 respostas, sendo em sua maioria do gênero feminino (72,8%), com idade de 18 a 35 anos (70,9%), solteiro (61,9%), com alta escolaridade (87,8%) e renda familiar mensal de dois a quatro salários mínimos (25,1%). Observou-se que a maioria dos participantes que realizam a compra de alimentos para suas casas (61,2%), tem preferência de fazê-la em supermercados (62,2%), consideram o odor e a aparência da carne bovina os atributos mais importantes para a sua aquisição (64,8% e 64,4%, respectivamente) e consomem esse alimento de duas a quatro vezes por semana (47,8%). Os participantes têm familiaridade com o tema de RC (34,7%), consideram sua utilização muito importante para os alimentos e que a informação sobre o RC esteja presente no rótulo (96%). Sobre a aplicação do RC na carne bovina, os participantes consideram que essa tecnologia é muito interessante para a conservação desse alimento (51,1%), porém têm curiosidade em conhecer o produto para obterem as próprias conclusões (73,2%). Diante do exposto, concluímos que os consumidores acreditam que a aplicação de RC pode ter um grande potencial para conservação da carne bovina fresca durante o armazenamento.
Análise de desempenho de ovelhas e cordeiros Ile de France
Authors: Costa Ana Lúcia Barreto da , Freitas Thaís Campos de , Debortli Elísio de Camargo , Sbardelotto Edriane Mara , Lemes Jaqueline Schneider
Published: February 2022

Os sistemas de produção dos ovinos no Rio Grande do Sul apresentam-se de forma diversificada. Como consequência destes sistemas adotados, alguns índices produtivos e reprodutivos médios do rebanho tornam-se inferiores ao potencial dos rebanhos. O objetivo deste estudo foi avaliar o desempenho produtivo de ovelhas e cordeiros da raça Ile de France criados em sistema extensivo em campo nativo na mesorregião Nordeste do Rio Grande do Sul. O experimento foi realizado na Cabanha Lagoa, localizada no município de Capão Bonito do Sul. Foram utilizados dados de manejos de 33 matrizes ovinas e 37 cordeiros, da raça Ile de France. Os dados referem-se aos ciclos de produção de cordeiros nascidos em 2018, acompanhados até os 340 dias de vida e desempenho de matrizes do ciclo de produção de 2019. Ao avaliar a eficiência das matrizes, levando em consideração o sexo dos cordeiros, constatou-se que não houve diferença significativa tanto para o peso ao parto quanto ao desmame. Para a eficiência das matrizes de acordo com o tipo de parto (simples ou múltiplo), foi possível identificar que a eficiência da ovelha ao parto (EFp) foi superior nos partos múltiplos. Já os cordeiros de partos simples obtiveram maior peso em Kg que os cordeiros de parto múltiplo. Matrizes de partos múltiplos apresentaram desempenho superior (104% de seu peso vivo desmanado) em relação à eficiência produtiva se comparados com matrizes de parto simples (65% de seu peso desmamado). Em relação à evolução de peso, cordeiros de parto simples obtiveram pesos superiores do que animais de partos múltiplos.
O Enfermeiro frente à oxigenação por Membrana Extracorpórea (ECMO)
Authors: Maximiano Luzia Cibele de Souza , Araújo Maria Eduarda da Silva , Dantas Luana Adrielle Leal , Rodrigues Helder Barbosa , Duarte Keylla Isabelle Sousa , Martins Monique Veríssimo , Silva Leilane Alice Moura da , Almeida Valéria Duarte de , Santos Heitor Lenin Lisboa dos , Costa Jessica Larissa dos Santos
Published: February 2022

Objetivo: Identificar como se dá a prática dos cuidados críticos de enfermagem aos pacientes que são submetidos à circulação extracorpórea. Metodologia: Trata-se de uma revisão da literatura, seguindo as orientações preconizadas pelo Preferred Reporting Items Systematic Reviews and Meta-Analyses (PRISMA) e organizada nas seguintes etapas: elaboração do protocolo da revisão; coleta dos dados com inclusão de publicações que trouxeram contribuições e respostas pertinentes à questão de pesquisa; extração das informações contidas no estudo; análise e interpretação dos dados; e, por último, apresentação e discussão da revisão. Resultados e discussão: Foram selecionados inicialmente 137 artigos nas bases de dados e após seleção minuciosa, restaram 12 artigos para compor os resultados. Estudos descritivos, retrospectivos e de coorte fazem parte desta amostra. Após análise dos dados, foi observado que apenas metade das UTIs possuíam profissionais com experiência em ECMO e somente 46% dos enfermeiros foram capazes de cuidar, de forma independente, de pacientes em VV-ECMO. Isso nos mostra que o número de enfermeiros intensivistas experientes e treinados é baixo, o que faz com que aconteça uma sobrecarga desses profissionais. Juntamente com a experiência, mostra-se necessária a educação continuada e padronizada para aumentar o número de profissionais que possam manusear esta terapia de alta complexidade. Conclusão: De acordo com os estudos analisados, verificamos que a ECMO é considerada uma técnica cada vez mais presente nos cuidados à pessoa em situação crítica com necessidade de suporte cardiopulmonar mecânico em situações de insuficiência respiratória grave, insuficiência cardíaca ou em ambas.
Impactos na saúde mental dos profissionais de saúde atuantes na linha de frente a pandemia do COVID-19
Authors: Silva Maria Eduarda Wanderley de Barros , Santos Thaís Andrade dos , Silva Vivian Marinho da , Siqueira Juliana Alves de , Ribeiro Yasmin Bezerra , Silva Bárbara Letícia Sabino , Sousa Conceição Aparecida Silva , Arruda Mharianna Phaitter Silva , Barbosa Maria Letícia Cardoso da Silva , Varela Fernanda Félix de Araújo , Teixeira Maria Conceição Diniz , Martins Rubens de Andrade , Arruda Thalita Emília Correia , Silva Dulcineide Maria da , Soares Larissa Lima
Published: February 2022

Trata-se de uma revisão integrativa da literatura de abordagem qualitativa. Sendo seguida as seguintes etapas de   identificação do tema e seleção da pesquisa, elaboração dos critérios de exclusão e inclusão, seleção dos estudos categorização dos estudos selecionados, análise e interpretação dos resultados. A pesquisa teve como pergunta norteadora a seguinte questão: “Quais os impactos a pandemia do COVID-19 trouxeram na saúde mental dos profissionais atuantes na linha de frente?”. Os estudos destacam as consequências da pandemia do covid-19 na vida dos profissionais de saúde, ao apontar que a exposição a uma situação de emergência em saúde pública provocou risco ocupacional e sofrimento psicológico devido ao trauma, desvalorização profissional, auto isolamento e quarentena. Com isso, foi desencadeado diversos impactos negativos na saúde mental dos profissionais manifestando-se mediante a sintomas de insônia, angústia, ansiedade, depressão, medo, frustração e estresse pós-traumático. Conclui-se que, os impactos que a pandemia trouxe com a chegada de um novo vírus pouco conhecido, atingiu diretamente na sociedade e refletiu nos profissionais da saúde que atuam na linha de frente, contudo, o apoio e o acolhimento psicológico poderão contribuir para encarar os efeitos da pandemia na saúde mental, além de outras alternativas como cursos de capacitações para orientar a equipe de saúde no tratamento e enfrentamento de problemas psicológicos.
Health evaluation of three types of baths in patients with severe heart diseases
Authors: Santos Silvia Regina Martins dos , Lôbo Anna Beatriz Alves Pereira , Reis Fernanda Faria , Silva Monyque Evelyn dos Santos , Oliveira Aretha Pereira de , Machado Dalmo
Published: February 2022

Aim: To analyze the cost of three bed bath technologies in critically ill cardiac patients. Study design: Non-participant, prospective, observational, and cost assessment study. Data were collected between February and August 2017, at the cardiac intensive care (ICU) of a university hospital. The convenience sample corresponded to 18 patients in the immediate postoperative period of cardiac surgery. Data were collected within 72 h after cardiac surgery, with 24-hour washout between baths. Project was approved under the number: 1.823.316. Results: The mean time for bed bath was 39.00±15.00 min (traditional bath), 33.00±12.24 min (distilled water bath) and 25.28±7.35 min (disposable bath). The average final costs identified were R$ 45.47 (US$ 8.80), R$ 40.78 (US$ 7.89) and R$ 48.36 (US$ 9.36). Conclusion: The bath with the lowest total average cost was the distilled water bath. The cost category that most burdens the bed baths is human capital, which represents more than 2/3 of the procedures total cost. There are few studies exploring the costs associated to nursing procedures, and this analysis can contribute to discussions about materials purchase and support managers to make better decisions about nursing care.
PENGEMBANGAN APLIKASI MONITORING KELUHAN PELANGGAN MYREPUBLIC PALEMBANG
Authors: Sopiah Nyimas , Sutopo Bayu
Published: February 2022

Keluhan pelanggan merupakan salah satu indikator, gejala, dan tanda adanya ketidakpuasan atas produk atau layanan perusahaan. Hal ini mengakibatkan banyak pelanggan yang merasa kurang puas karena proses tanggapan dan penanganan keluhan memakan waktu yang cukup lama. Proses yang lama ini disebabkan oleh karena kantor cabang Myrepublic Kota Palembang belum memiliki sistem layanan keluhan pelanggan secara tersendiri, sehingga untuk menangani semua laporan keluhan masih di limpahkan ke Kantor Pusat Jakarta. Solusi dalam mengatasi permasalahan tersebut, dengan membangun sebuah aplikasi  monitoring yang dapat mengelola penanganan keluhan pelanggan Myrepublic Kota Palembang. Sehingga pelanggan dapat mengajukan laporan keluhan secara langsung tanpa harus melalui kantor pusat Myrepublic Jakarta. Dengan demikian akan memudahkan dan mempercepat waktu proses penanganan keluhan. Selain itu, pelanggan juga dapat melakukan monitoring atau pengawasan untuk kasus perbaikan yang memakan waktu yang lebih dari satu hari. Dengan demikian pelanggan akan merasa nyaman dan betah untuk tetap menggunakan layanan Myrepublic. Sistem yang dibangun dengan menggunakan metode Web Engineering dan bahasa pemrograman PHP, serta menggunakan MySQL sebagai bahasa pemrograman database.
ANALISA JARINGAN LOKAL AREA NETWORK (LAN) DI SALAH SATU HOTEL WILAYAH JAKARTA TIMUR
Authors: KN Nurwijayanti
Published: February 2022

Abstract:The development of information technology is increasing every year, one of the applications of information technology is the Loal Area Network (LAN), which is applied in a hotel located in the East Jakarta area, the hotel has 10 floors, consisting of the 1st floor as a server and computer clients are located on floors 2-10. Due to the large number of complaints from guests, especially Wi-Fi network problems, it is necessary to check the maintenance section to see the quality of the network on each floor and an analysis is needed, where the analysis uses the method of calculating QoS (Quality Of Service) using 3 parameters, namely: Delay, Throughput and Packet Loss, with the standards used according to the TIPHON standard to determine the level of computer network quality. The results of the analysis at the hotel can be said to be very good, Delay is said to be very good, Throughput is said to be Good and Packet Loss is said to be Good, then the QoS results on Monday - Sunday obtained an index of 3 which is categorized as Satisfactory, then after analyzing the problem, only bandwidth problems must be enlarged so that the delay is getting smaller.

Abstrak: Perkembangan teknologi informasi semakinmeningkat tiap tahunnya, salah satu aplikasi teknologi informasi adalah jaringan Lokal Area Network (LAN), yang diaplikasikan di salah satu hotel yang terletak di wilayah Jakarta Timur, hotel tersebut memiliki 10 lantai, yang terdiri dari lantai 1 sebagai server dan  komputer client terletak di lantai 2-10. Karena banyaknya komplain dari para tamu terutama masalah jaringan Wi-Fi, maka perlu adanya pengecekan dibagian maintenance untuk melihat kualitas jaringan ditiap lantai dan perlu dilakukan analisa, dimana analisanya menggunakan metode menghitung QoS (Quality Of Service) menggunakan 3 parameter yaitu : Delay, Throughput dan Packet Loss, dengan standar yang dipakai sesuai standar TIPHON untuk menentukan tingkat kualitas jaringan komputer. Hasil analisa di hotel tersebut di dapat Delay dikatakan sangat bagus, Throughput dikatakan Bagus dan Packet Loss dikatakan Bagus, maka di dapat hasil QoS pada hari Senin – Minggu didapat indeks sebesar 3 dikatagorikan Memuaskan, maka setelah di analisa permasalahannya hanya masalah bandwidth yang harus diperbesar agar delay semakin kecil.
Equations of Prolate Spheroid in Spherical Polar Coordinates and its Surface Area by Analytical Method
Authors: Soltani Abolfazl
Published: February 2022

As you know we do not have any exact equation for calculation Prolate Spheroid surface area. Here we will obtain this equation by analytical method. Moreover, here we will obtain the prolate spheroid equation, when the center is a focal point of prolate spheroid.
The Activation Pattern of Drug-Reacting T Cells Has an Impact on the Clinical Picture of Hypersensitivity Reactions
Authors: Wuillemin Natascha , Ballmer-Weber Barbara , Schlapbach Christoph , Jörg Lukas , Yerly Daniel
Published: February 2022

Rationale

β-lactam antibiotics cause drug hypersensitivity reactions (DHR) with various clinical pictures from minor affections like maculopapular exanthema (MPE) and urticaria to severe cutaneous adverse reactions and anaphylaxis. Currently, two different reactivity patterns have been shown to initiate an immune reaction by activating T cells—the hapten concept and the pharmacological interaction with immune receptor (p–i) concept.

Objectives

In this study, the relationship between the reactivity pattern of drug-reacting T cells of drug allergic patients and their clinical picture has been investigated.

Findings

Drug-reacting T-cell clones (TCCs) were isolated from patients hypersensitive to β-lactams. Analysis of their reactivity pattern revealed an exclusive use of the hapten mechanism for patients with immediate reactions and for patients of MPE. In patients suffering from drug reactions with eosinophils and systemic symptoms, a severe DHR, analysis of isolated drug-reacting TCC identified the p–i concept as the unique mechanism for T-cell activation.

Conclusions

The results show a shift from hapten pattern in mild allergic reactions to p–i pattern in severe life-threatening allergic reactions. They strongly argue against the current preclinical risk evaluation of new drugs based on the ability to form haptens.
A Coupled Biomechanical-Smoothed Particle Hydrodynamics Model for Horse Racing Tracks
Authors: Harrison Simon M. , Whitton R. Chris , Stover Susan M. , Symons Jennifer E. , Cleary Paul W.
Published: February 2022

Distal limb injuries are common in racing horses and track surface properties have been associated with injury risk. To better understand how track surfaces may contribute to equine limb injury, we developed the first 3D computational model of the equine hoof interacting with a racetrack and simulated interactions with model representations of 1) a dirt surface and 2) an all-weather synthetic track. First, a computational track model using the Smoothed Particle Hydrodynamics (SPH) method with a Drucker-Prager (D-P) elastoplastic material model was developed. It was validated against analytical models and published data and then calibrated using results of a custom track testing device applied to the two racetrack types. Second, a sensitivity analysis was performed to determine which model parameters contribute most significantly to the mechanical response of the track under impact-type loading. Third, the SPH track model was coupled to a biomechanical model of the horse forelimb and applied to hoof-track impact for a horse galloping on each track surface. We found that 1) the SPH track model was well validated and it could be calibrated to accurately represent impact loading of racetrack surfaces at two angles of impact; 2) the amount of harrowing applied to the track had the largest effect on impact loading, followed by elastic modulus and cohesion; 3) the model is able to accurately simulate hoof-ground interaction and enables study of the relationship between track surface parameters and the loading on horses’ distal forelimbs.
Applications of Tissue Decellularization Techniques in Ventricular Myocardial Biofabrication
Authors: Krishnan Aravind , Wang Hanjay , MacArthur John Ward
Published: February 2022

Ischemic heart disease is the leading cause of death around the world, and though the advent of coronary revascularization has revolutionized its treatment, many patients who sustain ischemic injury to the heart will go on to develop heart failure. Biofabrication of ventricular myocardium for replacement of irreversibly damaged ischemic myocardium is sought after as a potential therapy for ischemic heart failure, though challenges in reliably producing this biomaterial have limited its clinical application. One method that shows promise for generation of functional myocardium is the use of tissue decellularization to serve as a scaffold for biofabrication. This review outlines the methods, materials, challenges, and prospects of tissue decellularization techniques for ventricular myocardium biofabrication. Decellularization aims to preserve the architecture and composition of the extracellular matrix of the tissue it is applied to, allowing for the subsequent implantation of stem cells of the desired cell type. Decellularization can be achieved with multiple reagents, most of which have detergent properties. A variety of cell types can be implanted in the resulting scaffold, including cardiac progenitor cells, and embryonic or induced pluripotent stem cells to generate a range of tissue, from patches to beating myocardium. The future of this biofabrication method will likely emphasize patient specific tissue engineering to generate complex 3-dimensional constructs that can replace dysfunctional cardiac structures.
In Vitro Disease Models for Understanding Psoriasis and Atopic Dermatitis
Authors: Sarama Roudin , Matharu Priya K. , Abduldaiem Yousef , Corrêa Mab P. , Gil Cristiane D. , Greco Karin V.
Published: February 2022

Psoriasis (PS) and Atopic Dermatitis (AD) are two of the most prevalent inflammatory skin diseases. Dysregulations in the immune response are believed to play a crucial role in the pathogenesis of these conditions. Various parallels can be drawn between the two disorders, as they are both genetically mediated, and characterised by dry, scaly skin caused by abnormal proliferation of epidermal keratinocytes. The use of in vitro disease models has become an increasingly popular method to study PS and AD due to the high reproducibility and accuracy in recapitulating the pathogenesis of these conditions. However, due to the extensive range of in vitro models available and the majority of these being at early stages of production, areas of development are needed. This review summarises the key features of PS and AD, the different types of in vitro models available to study their pathophysiology and evaluating their efficacy in addition to discussing future research opportunities.
Pleiotropic Effects of Simvastatin and Losartan in Preclinical Models of Post-Traumatic Elbow Contracture
Authors: David Michael A. , Reiter Alex J. , Dunham Chelsey L. , Castile Ryan M. , Abraham James A. , Iannucci Leanne E. , Shah Ishani D. , Havlioglu Necat , Chamberlain Aaron M. , Lake Spencer P.
Published: February 2022

Elbow trauma can lead to post-traumatic joint contracture (PTJC), which is characterized by loss of motion associated with capsule/ligament fibrosis and cartilage damage. Unfortunately, current therapies are often unsuccessful or cause complications. This study aimed to determine the effects of prophylactically administered simvastatin (SV) and losartan (LS) in two preclinical models of elbow PTJC: an in vivo elbow-specific rat injury model and an in vitro collagen gel contraction assay. The in vivo elbow rat (n = 3–10/group) injury model evaluated the effects of orally administered SV and LS at two dosing strategies [i.e., low dose/high frequency/short duration (D1) vs. high dose/low frequency/long duration (D2)] on post-mortem elbow range of motion (via biomechanical testing) as well as capsule fibrosis and cartilage damage (via histopathology). The in vitro gel contraction assay coupled with live/dead staining (n = 3–19/group) evaluated the effects of SV and LS at various concentrations (i.e., 1, 10, 100 µM) and durations (i.e., continuous, short, or delayed) on the contractibility and viability of fibroblasts/myofibroblasts [i.e., NIH3T3 fibroblasts with endogenous transforming growth factor-beta 1 (TGFβ1)]. In vivo, no drug strategy prevented elbow contracture biomechanically. Histologically, only SV-D2 modestly reduced capsule fibrosis but maintained elevated cellularity and tissue hypertrophy, and both SV strategies lessened cartilage damage. SV modest benefits were localized to the anterior region, not the posterior, of the joint. Neither LS strategy had meaningful benefits in capsule nor cartilage. In vitro, irrespective of the presence of TGFβ1, SV (≥10 μM) prevented gel contraction partly by decreasing cell viability (100 μM). In contrast, LS did not prevent gel contraction or affect cell viability. This study demonstrates that SV, but not LS, might be suitable prophylactic drug therapy in two preclinical models of elbow PTJC. Results provide initial insight to guide future preclinical studies aimed at preventing or mitigating elbow PTJC.
Protein Splicing of Inteins: A Powerful Tool in Synthetic Biology
Authors: Wang Hao , Wang Lin , Zhong Baihua , Dai Zhuojun
Published: February 2022

Inteins are protein segments that are capable of enabling the ligation of flanking extein into a new protein, a process known as protein splicing. Since its discovery, inteins have become powerful biotechnological tools for applications such as protein engineering. In the last 10 years, the development in synthetic biology has further endowed inteins with enhanced functions and diverse utilizations. Here we review these efforts and discuss the future directions.
Genomic Editing: The Evolution in Regulatory Management Accompanying Scientific Progress
Authors: Goberna María Florencia , Whelan Agustina Inés , Godoy Perla , Lewi Dalia Marcela
Published: February 2022

Argentina currently has a regulation for genome-editing products whose criteria were updated as consultations were received to determine the regulatory status of these products. The aim of this regulation is to consider all organisms (animals, micro-organisms and plants) under the same NBT resolution independently and without being linked to commercial Genetically Modified Organism (GMO) regulations. This gives certainty to local researchers and developers (teams of local developers and researchers), which can be seen in the number of developments and consultations carried out. It should be noted that early results showed that the speed of innovation of these technologies was increasing in a short time, giving more opportunity to local developers who showed interest in generating products in different species, crops and phenotypes.
Enhancing the Catalytic Performance of Candida antarctica Lipase B by Chemical Modification With Alkylated Betaine Ionic Liquids
Authors: Xue Yu , Zhang Xiao-Guang , Lu Ze-Ping , Xu Chao , Xu Hua-Jin , Hu Yi
Published: February 2022

Various betaine ionic liquids composed of different chain lengths and different anions were designed and synthesized to modify Candida antarctica lipase B (CALB). The results showed that the catalytic activity of all modified lipases improved under different temperature and pH conditions, while also exhibiting enhanced thermostability and tolerance to organic solvents. With an increase in ionic liquid chain length, the modification effect was greater. Overall, CALB modified by [BetaineC16][H2PO4] performed best, with the modified CALB enzyme activity increased 3-fold, thermal stability increased 1.5-fold when stored at 70°C for 30 min, with tolerance increased 2.9-fold in 50% DMSO and 2.3-fold in 30% mercaptoethanol. Fluorescence and circular dichroism (CD) spectroscopic analysis showed that the introduction of an ionic liquid caused changes in the microenvironment surrounding some fluorescent groups and the secondary structure of the CALB enzyme protein. In order to establish the enzyme activity and stability change mechanisms of the modified CALB, the structures of CALB modified with [BetaineC4][Cl] and [BetaineC16][Cl] were constructed, while the reaction mechanisms were studied by molecular dynamics simulations. Results showed that the root mean square deviation (RMSD) and total energy of modified CALB were less than those of native CALB, indicating that modified CALB has a more stable structure. Root mean square fluctuation (RMSF) calculations showed that the rigidity of modified CALB was enhanced. Solvent accessibility area (SASA) calculations exhibited that both the hydrophilicity and hydrophobicity of the modified enzyme-proteins were improved. The increase in radial distribution function (RDF) of water molecules confirmed that the number of water molecules around the active sites also increased. Therefore, modified CALB has enhanced structural stability and higher hydrolytic activity.