bluuebunny/crossref_metadata_2025 huggingface dataset:
Model of Process Management System in Enterprises of the Hard Coal Mining Industry
Authors: Bijańska Jolanta , Wodarski Krzysztof
Published: May 2020

The primary objective of this paper is to present a model of a process management system developed to support the restructuring of Polish enterprises of the hard coal mining industry. The development of this model required research in three stages using several research methods. The stage I of the research was oriented towards the recognition of the existing state of knowledge in the scope of previously developed models of process management in enterprises. At this stage, a method of reviewing the literature, the analysis and synthesis of the results of considerations, was used. The stage II was oriented towards presenting of the current state of knowledge in the field of process management to the managerial staff of mines in order to identify their needs, capabilities and preferences. The research were attended by 24 managers from PGG SA and JSW SA. At this stage, the method of targeted free-form interview and discussions, was used. The stage III of the research was oriented towards the development of a process management system model in enterprises operating in the hard coal mining industry, based on the scientific achievements to date in the field of process management and consensus on the needs, preferences and capabilities of mine managerial staff with regard to its specific elements. At this stage, the method of analysis and synthesis was used. The results of the research presented in this publication are primarily addressed to the managerial staff of polish hard mines, as they provide a synthesized response to the problem of the lack of consistent process management guidelines that could set a standard within a mining enterprise. The model presented in the publication is of a general nature, although it may provide a basis for the application of process management for mines.
Sorafenib for the treatment of hepatocellular carcinoma: a single-centre real-world study
Authors: Hanzel Jurij , Kosir Bozic Tajda , Stabuc Borut , Jansa Rado
Published: May 2020

Background

Sorafenib is an oral multi-kinase inhibitor used for the treatment of hepatocellular carcinoma. Its efficacy in randomised controlled trials was demonstrated in patients with well-preserved liver function and good functional status. In the real-world setting, treatment is often offered to patients outside these criteria. We therefore performed a single-centre real-world cohort study on the efficacy of sorafenib in patients with hepatocellular carcinoma.

Patients and methods

We identified all patients with hepatocellular carcinoma initiating treatment with sorafenib between January 2015 and January 2018. The primary endpoint was overall survival (OS) since starting sorafenib. Clinical and demographic variables associated with survival were studied.

Results

The median OS was 13.4 months (95% CI 8.2–18.6). Multivariable Cox’s regression identified worse ECOG performance status (HR 2.21; 95% CI 1.56–3.16; P < 0.0001), Child-Pugh class C (HR 52.4; 95% CI 3.20–859; P = 0.005) and absence of prior locoregional treatment (HR 2.30; 95% CI 1.37–3.86; P = 0.002) to be associated with increased mortality.

Conclusions

Careful selection of patients for treatment with sorafenib is of paramount importance to optimize outcomes.
Prognostic role of positron emission tomography and computed tomography parameters in stage I lung adenocarcinoma
Authors: Carretta Angelo , Bandiera Alessandro , Muriana Piergiorgio , Viscardi Stefano , Ciriaco Paola , Gajate Ana Maria Samanes , Arrigoni Gianluigi , Lazzari Chiara , Gregorc Vanesa , Negri Giampiero
Published: May 2020

Background

According to the current pathological classification, lung adenocarcinoma includes histological subtypes with significantly different prognoses, which may require specific surgical approaches. The aim of the study was to assess the role of CT and PET parameters in stratifying patients with stage I adenocarcinoma according to prognosis.

Patients and methods

Fifty-eight patients with pathological stage I lung adenocarcinoma who underwent surgical treatment were retrospectively reviewed. Adenocarcinoma in situ and minimally-invasive adenocarcinoma were grouped as non-invasive adenocarcinoma. Other histotypes were referred as invasive adenocarcinoma. CT scan assessed parameters were: ground glass opacity (GGO) ratio, tumour disappearance rate (TDR) and consolidation diameter. The prognostic role of the following PET parameters was also assessed: standardized uptake value (SUV) max, SUVindex (SUVmax to liver SUVratio), metabolic tumour volume (MTV), total lesion glycolysis (TLG).

Results

Seven patients had a non-invasive adenocarcinoma and 51 an invasive adenocarcinoma. Five-year disease-free survival (DFS) and cancer-specific survival (CSS) for non-invasive and invasive adenocarcinoma were 100% and 100%, 70% and 91%, respectively. Univariate analysis showed a significant difference in SUVmax, SUVindex, GGO ratio and TDR ratio values between non-invasive and invasive adenocarcinoma groups. Optimal SUVmax, SUVindex, GGO ratio and TDR cut-off ratios to predict invasive tumours were 2.6, 0.9, 40% and 56%, respectively. TLG, SUVmax, SUVindex significantly correlated with cancer specific survival.

Conclusions

CT and PET scan parameters may differentiate between non-invasive and invasive stage I adenocarcinomas. If these data are confirmed in larger series, surgical strategy may be selected on the basis of preoperative imaging.
Ecclesiological Tendencies in the Ecumenical Approach of the Council of Crete
Authors: Crișan Alexandru-Marius
Published: May 2020

The Ecumenical legacy of the Council of Crete convened in 2016 is extremely important because of the consistent discussions on this topic during the grounding of the Council, but mostly subsequent to that, when the process of reception of the Council began. The Holy and Great Council of Crete of 2016, known also as the Pan-Orthodox Council, issued six official documents plus a Message and an Encyclical. Among those documents, one is dedicated to the question of ecumenical relations. Inside various Orthodox Autocephalous Churches different groups denounced the Council because of its ecumenical approach, meaning that a good understanding of the ecumenical legacy of the Council of Crete is one of the most important keys in its reception. In this study I will try to inspect the ecclesiological theology found in the Document on Ecumenical Relations released in 2016 by the Council of Crete, thereby analyzing why some of the groups rejected this document. Comparing different forms of the documents with the final approved form will help us understand how the Orthodox approach to ecumenism evolved in time, since the beginning of the preparations for the Holy and Great Council of the Orthodox Church.
Does Stress Lead to Creativity?: The Relationship Between Occupational Stress and Individual Innovative Behavior
Authors: Luis Daniel Jose , Ruth Chatelain-Jardon , Zhuofan Zhang
Published: May 2020

Individual innovative behavior can have important implications for organizations. This article studies the relationship between occupational stress and individual innovative behavior. Data from 139 subjects from the US was analyzed using structural equation modeling as the technique. Results from partial least squares show that there is a positive and significant relationship between both constructs. Moreover, both variables present a U form relationship. Based on this research, it could be concluded that occupational stress could influence positively innovative behavior at work. Practical implications suggest that innovative behavior could be boost by identifying conditions at work that could produce time pressure. Elements such as work overload, feedback and allowing employees to take risks could help in idea generation.
Parameter Estimation of the Temporal Point Process Model through the Bayesian Approach (Case Study : Malaria Disease Data from Wahidin Hospital in Makassar City)
Authors: Darwis Darwis , N Sunusi , A.J. Kresna
Published: May 2020

Penelitian ini bertujuan mengestimasi parameter melalui pendekatan Bayesian dari model temporal point process. Paramater intensitas bersyarat model tersebut dipandang sebagai suatu renewal process yang selanjutnya digunakan melalui pendekatan Squared Error Loss Function (SELF). Parameter intensitas bersyarat model temporal point process diestimasi menggunakan metode maximum likelihood estimation melalui persamaan likelihood point process.  Selain itu, penelitian ini mengkaji metode estimasi maksimum likelihood dan metode Bayes untuk menganalis fungsi resiko dari hasil penaksir parameter intensitas bersyarat. Pada aplikasi estimasi parameter ini, studi kasus yang digunakan adalah menganalisa data orang yang terkena penyakit malaria yang datanya berasal dari Rumah Sakit Wahidin Kota Makassar. Studi kasus tersebut menghasilkan nilai  yang merupakan nilai resiko penaksir MLE yang lebih tinggi dibandingkan dengan menggunakan Metode Bayes sedangkan nilai  merupakan hasil nilai resiko dari penaksir MLE yang lebih kecil dibandingkan dengan menggunakan Metode Bayes. This study parameter estimation of conditional intensity with temporal point process model by Bayesian approach. The conditional intensity with temporal point process model derived as a renewal process where inter event time is defined as its random variable. Squared Error Loss Function (SELF) approach is used to estimate the parameter of conditional intensity with temporal point process model which is happened as a renewal process using Bayesian. The other outlines of this paper is to determine the Risk Function as the result of estimation of conditional intensity by Bayesian and by Maximum likelihood Estimation (MLE). The application taking an analysis of Malaria at a place, which is properly conclude that the estimation using MLE method is more risky than the Bayesian it self.
La certificación profesional y la capacitación, como apoyo al contador público en las competencias que le requiere el mercado laboral
Authors: Vera Muñoz María Antonieta Monserrat , Martínez Méndez Rafaela , Martínez Méndez José Gerardo Serafín
Published: May 2020

RESUMEN El mercado laboral exige competencias a los colaboradores de las empresas y estas no se construyen por sí solas en los individuos, hay que generarlas y mantenerlas. Por lo que la investigación persigue como objetivo Indagar el apoyo que la capacitación y la certificación profesional aportan al Contador Público para adquirir y fortalecer las competencias que le son requeridas por el mercado laboral. Considerando una estrategia metodológica cualitativa, para examinar conceptos teóricos y contrastarlos con la información obtenida en el trabajo de campo e identificar la interacción y relación entre la capacitación y certificación profesional con las competencias. Teniendo como limitante que los sujetos de estudio se ubican en la ciudad de Puebla. Los resultados muestran de manera particular a la capacitación conjuntamente con la certificación en los profesionales de la Contaduría Pública como apoyo para acumular competencias que les permitan enfrentar exitosamente el mercado laboral. Concluyendo que los empleadores denotan preferencia especificas por algunas competencias.
TECNOLOGIAS DIGITAIS COMO INSTRUMENTOS MEDIADORES NO PROCESSO DE APRENDIZAGEM DAS ANOMALIAS CRANIOFACIAIS
Authors: Neves Liliane Elise Souza , Oliveira Amanda Almeida de , Figueira Manuela Almeida Santos da , Pereira Rui Manuel Rodrigues , Boll Cíntia Inês
Published: May 2020

RESUMOAs anomalias craniofaciais constituem um grupo diverso e complexo de defeitos congênitos impondo um significativo impacto sobre a qualidade de vida do indivíduo e de toda a sua família. Nesta realidade, o fonoaudiólogo apresenta-se como profissional indispensável no processo de reabilitação, todavia, a formação do mesmo não predispõe dos conhecimentos necessários para uma visão integral do portador da anomalia. Este estudo tem por objetivo, portanto, discutir a utilização das Tecnologias Digitais como instrumentos mediadores da aprendizagem de estudantes e profissionais, levando-se em consideração as mudanças nas interações sociais na sociedade contemporânea que contribuem para a constituição da subjetividade.Palavras-chave: Anomalia Craniofacial. Educação Permanente. Educação em Saúde. Tecnologia em Saúde. ABSTRACTCraniofacial anomalies constitute a diverse and complex group of birth defects that have a significant impact on the quality of life of individuals and their families. In this reality the speech therapist is presented as an indispensable professional in the rehabilitation process, however, the training of the same do not predispose the knowledge necessary for an integral view of the patient with the anomaly. Therefore, this study aims to discuss the use of Digital Technologies as mediators in the learning of students and professionals, taking into account the changes in social interactions in contemporary society that contribute to the constitution of subjectivity.Keywords: Craniofacial Abnormalities. Education Continuing. Health Education. Biomedical Technology.
URBAN NARRATIVES: A VIDEO-LETTER PROCESS WITH THE NEWSPAPER BOCA DE RUA
Authors: Bechler Janaina , Sousa Edson Luiz André
Published: May 2020

ABSTRACTThe present study shares the process of the collective achievement of a video-letter regarding the city of Porto Alegre, made with a group of directors of the Boca de Rua (Street Mouthpiece) newspaper, which is made by the homeless people of Porto Alegre. It highlights a perspective that sees in the narrator of the city its expression, and bets that there is sharing and sociability stemming from the fragments of narratives produced by the multiplicities that compose it. As a basis, it introduces some concepts of narrative and self-narrative, assuming, based on psychoanalytic theory, that the “I” is eccentric to the subject, and that the self exists as a partial construction. Through the authors W. Benjamin, P. Ricoeur, J-M. Gagnebin, J. Butler e J. Lacan, it points out the importance of composing narratives in the assembly of oneself and the city, creating connections when appropriate, or even legitimizing the fragmentary character of the narrative. The article ends by presenting some narratives composed after the recordings made with the group in the locations chosen by them.Keywords: Boca de Rua newspaper. Video-letter. Porto Alegre. Self-narrative. RESUMOO presente estudo compartilha o processo de conquista coletiva de uma vídeo-carta sobre a cidade de Porto Alegre, realizada com um grupo de diretores do jornal Boca de Rua, feito pelos moradores de rua de Porto Alegre. Destaca uma perspectiva que vê no narrador da cidade sua expressão e aposta que há compartilhamento e sociabilidade decorrentes dos fragmentos de narrativas produzidas pelas multiplicidades que a compõem. Como base, introduz alguns conceitos de narrativa e autonarrativa, assumindo, com base na teoria psicanalítica, que o “Eu” é excêntrico ao sujeito e que o “Eu” existe como uma construção parcial. Através dos autores W. Benjamin, P. Ricoeur, J-M. Gagnebin, J. Butler e J. Lacan, ressalta a importância de compor narrativas na assembleia de si e da cidade, criando conexões quando apropriado ou até legitimando o caráter fragmentário da narrativa. O artigo termina apresentando algumas narrativas compostas após as gravações feitas com o grupo nos locais escolhidos por eles.Palavras-chave: Jornal Boca de Rua. Vídeo-carta. Porto Alegre. Autonarrativa.
THE ROLE OF LAND DEED OFFICIAL REGARDING LEGAL CERTAINTY OF COMPLETE SYSTEMATIC LAND REGISTRATION
Authors: Yubaidi Ricco Survival
Published: May 2020

As an acceleration program for land registration in Indonesia that is directly led by the President, Complete Systematic Land Registration (PTSL) should provide a guarantee of legal certainty and protection regarding land ownership rights. However, in fact, the role of the land deed official (PPAT), as a public official who receives a mandate from the Governmental Regulation no. 24 of 1997 regarding Land Registration, is not found within the implementation of PTSL. The present research aimed to investigate the role of PPAT in the implementation of PTSL. Using normative legal approach, this study employed literature study to collect the primary data. This research found that PPAT does not have any role in regulatory legislation regarding PTSL. If we see Governmental Regulation no. 24 of 1997, all transfers occurring after the issuance of the regulation requires PPAT’s deed as written evidence of land ownership. The adjudication committee as the PTSL implementer supposes to collaborate with PPAT to make sure that PTSL meets the steps of juridical data collection in order to obtain an orderly, complete land registration that provides legal certainty regarding land ownership right.
Konsep Pendidikan Islam yang Ideal: Upaya Pembentukan Keperibadian Muslim
Authors: Sholeh Sholeh
Published: May 2020

Pendidikan merupakan proses pembentukan kepribadian yang merupakan hasil dari proses pembelajaran. Melalui lembaga-lembaga pendidikan diharapkan tidak hanya mampu menghadapi masyarakat teknologi masa depan yang makin teknologis tetapi juga pendidikan berpengaruh terhadap proses pembentukan dan pengembangan sikap dan prilaku manusia. Pendidikan yang ideal diyakini dapat melayani pertumbuhan manusia dalam semua aspek, baik aspek spiritual, intelektual, imajinasi, maupun aspek ilmiah. Dengan demikian proses pendidikan ini sebaiknya mendorong aspek tersebut ke arah keutamaan serta pencapaian kesempurnaan hidup melalui pembentukan karakter kepribadian. Melalui pembentukan karakter kepribadian muslim diharapkan dapat melahirkan individu-individu yang baik, bermoral, berkualitas sehingga bermanfaat bagi dirinya, keluarganya, masyarakatnya, bangsanya serta umat manusia umumnya.
Etika Pergaulan Islami Santri Madrasah Aliyah (MA) di Pesantren Jabal Nur Kecamatan Kandis Kabupaten Siak
Authors: Ahmad Muhammad Yusuf , Tambak Syahraini , Syafitri Mira
Published: May 2020

Islam telah mengatur etika pergaulan remaja, perilaku tersebut merupakan batasan-batasan yang dilandasi nilai-nilai agama. Oleh karena itu perilaku tersebut harus diperhatikan, dipelihara dan dilaksanakan oleh para remaja. Berdasarkan studi permasalahan di Pesantren Jabal Nur Kecamatan Kandis Kabupaten Siak di temukan beberapa gejala sebagai berikut: (1) Ada sebagian para santri/santriwati dalam proses pergaulan yang masih berbicara yang kurang sopan kepada teman sebaya; (2) Ada sebagian para santri/santriwati kurang menghormati guru, hal ini bisa dilihat ketika bertemu mereka tidak menegur atau menyapa guru yang dijumpainya; (3) Ada sebagian didalam pergaulan antara santri dan santriwati tidak menjaga pandangannya terhadap sesama lawan jenis, yang akibatnya akan membawa dampak menimbulkan nafsu; (4) Ada sebagian dalam pergaulan antara santri dan santriwati saling membenci dan iri yang mengakibatkan antara mereka saling bermusuhan. Untuk mengetahui situasi yang lebih jelas terkait etika pergaulan remaja pada para santri/santriwati di Pesantren Jabar Nur Kecamatan Kandis Kabupaten Siak, maka penulis melakukan penelitian terkait etika pergaulan ini. Jenis penelitian ini adalah Deskriptif kuantitatif, penelitian ini berlokasi di Pesantren Jabal Nur Kecamatan Kandis Kabupaten Siak selama 4 bulan. Populasinya berjumlah 350 orang sedangkan sampelnya berjumlah 86 orang. Data primer yang dikumpulkan menggunakan angket, sedangkan data skunder berupa dokumentasi yang berhubungan dengan penelitian. Teknik pengolahan data dengan melakukan editing, skoring, dan tabulating. Berdasarkan analisis data peneliti memperoleh hasil penelitian 84,35% berada pada rentang 81-100%. Ini menggambarkan bahwa etika pergaulan Islami santri Madrasah Aliyah (MA) Pesantren Jabal Nur Kecamatan Kandis Kabupaten Siak pada kategori “Baik”.
Development of High-Specificity Fluorescent Probes to Enable Cannabinoid Type 2 Receptor Studies in Living Cells
Authors: Sarott Roman , Westphal Matthias , Pfaff Patrick , Korn Claudia , Sykes David , Thais Gazzi, , Brennecke Benjamin , Atz Kenneth , Weise Marie , Mostinski Yelena , Hompluem Pattarin , eline koers , Miljuš Tamara , Roth Nicolas , Asmelash Hermon , Vong Man , Piovesan Jacopo , Guba Wolfgang , Rufer Arne C. , A. Kusznir Eric , Huber Sylwia , Raposo Catarina , Zirwes Elisabeth A. , Osterwald Anja , Pavlovic Anto , Moes Svenja , Beck Jennifer , Benito-Cuesta Irene , Grande Teresa , ruiz de martin esteban Samuel , Yeliseev Alexei , Drawnel Faye , Widmer Gabriella , Holzer Daniela , Wel Tom van der , Mandhair Harpreet , Yuan Chen-Yin , Drobyski Wiliam , Saroz Yurii , Grimsey Natasha , Honer Michael , Fingerle Jürgen , Gawrisch Klaus , Romero Julian , Hillard Cecilia J. , Varga Zoltan V. , Stelt Mario van der , Pacher Pal , Gertsch Jürg , McCormick Peter , Ullmer Christoph , Oddi Sergio , Maccarrone Mauro , Veprintsev Dmitry B. , Nazare Marc , Grether Uwe , Carreira Erick
Published: May 2020

Pharmacological modulation of cannabinoid type 2 receptor (CB2R) holds promise for the treatment of numerous conditions, including inflammatory diseases, autoimmune disorders, pain, and cancer. Despite the significance of this receptor, researchers lack reliable tools to address questions concerning the expression and complex mechanism of CB2R signaling, especially in cell-type and tissue-dependent context. Herein, we report for the first time a versatile ligand platform for the modular design of a collection of highly specific CB2R fluorescent probes, used successfully across applications, species and cell types. These include flow cytometry of endogenously expressing cells, real-time confocal microscopy of mouse splenocytes and human macrophages, as well as FRET-based kinetic and equilibrium binding assays. High CB2R specificity was demonstrated by competition experiments in living cells expressing CB2R at native levels. The probes were effectively applied to FACS analysis of microglial cells derived from a mouse model relevant to Alzheimer’s disease and to the detection of CB2R in human breast cancer cells.
‘Sacrificial’ Supramolecular Assembly and Pressure-Induced Polymerization: Toward Sequence-Defined Functionalized Nanothreads
Authors: Gerthoffer Margaret , Wu Sikai , Chen Bo , Wang Tao , Huss Steven , Oburn Shalisa M , Crespi Vincent , Badding John , Elacqua Elizabeth
Published: May 2020

Limited supramolecular strategies have been utilized to synthesize sequence-defined polymers, despite the high utility of noncovalent interactions in materials design. Herein, we illustrate the utility of ‘sacrificial’ aryl-perfluoroaryl supramolecular synthons to synthesize sp3-hybridized nanothreads from sp2-enriched reactants. Our strategy features A-B reactant pairs in the form a phenol:pentafluorophenol co-crystal that is preorganized for an electronically-biased sequence-defined polymerization. The polymerization, initiated at 12 GPa, affords an alternating copolymer featuring exogenous –OH functionalities. The nanothread polymer exhibits crystallinity, as evidenced by a hexagonal X-ray diffraction pattern. The presence of the external substitution is confirmed through IR and Raman spectroscopy. Our approach realizes the first example of a functionalized sequence-defined nanothread through sacrificial supramolecular preorganization and presents a further approach for de novo design of complex nanothreads.
Phase Behavior in NaSiCON Electrolytes and Electrodes
Authors: Deng Zeyu , Sai Gautam Gopalakrishnan , Kolli Sanjeev Krishna , Chotard Jean-Nöel , Cheetham Anthony K. , Masquelier Christian , Canepa Pieremanuele
Published: May 2020

The replacement of the presently used liquid electrolytes by a non-flammable solid electrolyte is an important avenue to create safer batteries. The Natrium Superionic CONductor (NaSiCON) Na1+xZr2SixP3-xO12 (0 < x < 3) that displays high bulk ionic conductivity and good stability towards other NaSiCON-based electrodes is a good solid electrolyte in NaSiCON-based batteries. Despite the sizeable share of research on Na1+xZr2SixP3-xO12, the structural and thermodynamic properties of NaSiCON require better understanding for more efficient synthesis and optimization as a solid electrolyte, which often follows chemical intuition. Here, we analyze the thermodynamic properties of the NaSiCON electrolyte by constructing the Na1+xZr2SixP3-xO12 phase diagram, based on density functional theory calculations, a cluster expansion framework, and Monte Carlo simulations. Specifically, we build the phase diagram as a function of temperature and composition (0 < x < 3) for the high-temperature rhombohedral structure, which has been also observed in several positive electrode materials, such as Na3Ti2(PO4)3, Na3V2(PO4)3 and Na3Cr2(PO4)3. Through the phase diagram, we identify the concentration domains providing the highest Na+-ion conductivity and previously unreported phase-separation behavior across three different single-phase regions. Further, we note the similarities in the phase behavior between Na1+xZr2SixP3-xO12 and other NaSiCON-based mono-transition metal electrodes and discuss the potential competition between thermodynamics and kinetics in experimentally observed phase separation. Our work is an important addition in understanding the thermodynamics of NaSiCON-based materials and in the development of inexpensive Na-ion batteries. From our results we propose that the addition of SiO44– moieties to single-transition metal NaSiCON-phosphate-based electrodes will slow significantly the kinetics toward phase separation.
Microsecond Simulation Analysis of Carbonic Anhydrase – II in Complex with (+)- Cathechin Revealed Molecular Interactions Responsible for Its Amelioration Effect on Fluoride Toxicity
Authors: Yadav Pulala Raghuveer , Syed Hussain , Satyanarayana Sadam DV , Pindi Pavan Kumar
Published: May 2020

Fluorosis is a chronic condition caused by overexposure to fluoride, marked by impaired dental, skeletal, and non-skeletal health. In presence of excess fluoride ions, in severe cases calcification of the ligaments observed. Earlier studies have suggested that the disruption of carbonic anhydrase activity via ionic homeostasis change was associated with F toxicity. In a recent study, it was demonstrated that Tamarind fruit extract was effective in increasing the urinary F excretion in male Wistar rats via studying the mRNA expression of carbonic anhydrase II (CA II) in kidney homogenates using western blotting, immunohistochemistry and quantitative Realtime PCR based studies. We have carried out this study to understand the detailed molecular level interactions responsible for this tamarind extract based (+)-cathechin compound towards lowering the F toxicity via targeting CA-II. From our study, it was revealed that due to the ability of (+)-cathechin compound to bind tightly filling complete available space at the catalytically important site forming metal coordinated ionic bonds with His94, His96 and His119 residues helps in restricting F ions to interact with Zn ion located at the core of catalytic site responsible for its functionality. On the other hand, interaction of (+)-cathechin compound with Gln92 was observed to be critically important towards inducing conformational changes in CA-II, thus allowing (+)-cathechin compound to burry even deeply inside the catalytic site.
Specificity of Biomarker Detection in Microfluidic Sensors
Authors: Prakash Praneet , Varma Manoj
Published: May 2020

The microfluidics based point-of-care (POC) sensing devices offer unmatched possibilities of fast and high throughput diagnosis over conventional strategies. A major challenge for the early detection of disease is the significantly lower concentration of biomarkers as compared to the interfering noise molecules. In this work, we investigate the ‘reaction parameter’ phase space to identify suitable reaction parameters to enhance biomarker detection specificity. Under similar target biomarker and noise concentration levels, we show that a target biomarker is more likely to be detected at low concentrations and weak target and noise-receptor binding kinetics. Importantly, a simulation verified time-scale based methodology is developed to guide the appropriate choice of biomarkers for specific detection. This study demonstrates the prospect of successful POC diagnostic devices during early stage of diseases such as cancer.
加油站“家文化”建设的探索与实践
Authors: 刘 聚萍
Published: May 2020

随着人们对美好生活的向往和对高品质生活需求的提高，加油站作为石化销售企业的对外窗口，正在进行角色的快速转变。由原来单一的提供加油服务，转变为综合服务商一体化的购物消费、车辆洗护、餐饮享用、各类充值等人、车、生活的驿站。伴随着多角色的出现，原先单一的加油服务模式已很难满足各方需要。当加油站的经营模式进入改革快车道后，加油站的“家文化”建设就显得尤为重要。论文结合加油站“家文化”建设实践进行探讨了如何让加油站员工迅速适应这种变化，让客户感受这种变化，真正实现员工、客户、企业三满意以及油站增量、员工增收、企业增效的目的。
农村饮水安全工程建设与运行管理分析
Authors: 洪 宇
Published: May 2020

伴随着农村经济的发展进步以及社会的全面改革，当前中国农村农业正在迅速发展进步，但是与此同时，也造成了较重的环境污染问题。虽然人们的生活水平有所提升，但是农村饮水却出现了质量急剧下降、管理不善的问题。而且在农村地区建设过程中，饮水安全问题是非常重要的问题之一，必须对其加以重视。所以，在实际农村饮水安全工程的管理中，必须完善运行管理机制，保证饮水安全，维持健康的用水环境。
新媒体语境下影视文化价值观的传播
Authors: 刘 姝君
Published: May 2020

现如今人们的日常工作和生活变得丰富多彩，影视在这其中扮演着关键的角色。就新媒体语境下的影视文化而言，它所突出的不仅仅是传统意义上的视觉和听觉刺激，而是价值观之间的冲突，所包含的内容有每一个人的价值观和立场、每一件事物存在或者发生的理由。与此同时，影视文化价值观还受到互联网文化的影响，相应的传播方式发生了较大的变化。因此，论文就新媒体语境下影视文化价值观的传播进行分析和探索，旨在赋予中国影视文化更加丰富的内涵的和增强其传播途径的快捷性。
西兰卡普视觉符号在包装设计中的创新应用研究
Authors: 刘 京 , 向 洁
Published: May 2020

自古以来，中国是一个多民族的国家，发展至今已经有55个少数民族和汉族共同生活在一起，这其中以少数民族最为具有特色，他们不仅具备悠久的历史渊源，而且其中所包含的文化元素也更为丰富，这些少数民族视觉符号已经被众多设计师和学者应用到艺术设计领域。土家族是分布在中国湘、鄂、渝、黔毗连的武陵山区的少数民族，它特殊的织锦技术沿用至今，其中最具有文化特色的就是西兰卡普这一视觉符号，无论是色彩还是图案都十分显眼夺目，将其用在包装设计中不仅仅是对土家族文化的一种传承，使西兰卡普的民族元素与现代设计语言紧密结合在一起，更是探索其文化符号与现代审美需求相融的新路径。
Textmodalität in den Texten von F. Kafka und F. Dostojewski aus kontrastiver Sicht
Authors: Schipowa Irina A.
Published: May 2020

In dem Beitrag wird analysiert, wie einige Kategorien der Modalität in Texten von Kafka und Dostojewski realisiert werden und welchen pragmatischen Effekt sie produzieren können. Aus kontrastiver Sicht wird gezeigt, wie die Modalisierung vom Diskursmodell Erzählen im Deutschen und im Russischen erfolgen kann, welche Zielsetzung den Gebrauch von sprachlichen Mitteln die Modalität auf lexikalischer und morphosyntaktischer Ebene bestimmt, welche Modaloperatoren die Referenz der Modalität markieren und welches Zusammenwirken zwischen der Darstellungsart und dem Modalkern des Textes besteht.
Quantifizierung der Nominalphrase durch Aspekt und Aktionsarten im Polnischen und Deutschen
Authors: Kątny Andrzej
Published: May 2020

In dem Beitrag werden einige Auffassungen zu den Aktionsarten im Polnischen, Deutschen sowie in der anglistischen Fachliteratur skizzenhaft dargestellt. Den Hauptteil des Artikels stellen Erwägungen zum Einfluss des grammatischen und lexikalischen Aspekts auf die Quantifizierung der Nominalphrase in beiden Sprachen dar. Die diskutierte Problematik wird mit einer Reihe von Belegen veranschaulicht.
Zur narrativ-bildenden Funktion von Ephemera im ‚Grenzgebiet des Augenblicks‘
Authors: Taborska Katarzyna
Published: May 2020

Das Ziel des Beitrags ist die Darstellung der narrativ-bildenden Funktion von ausgewählten ephemeren Texten aus dem Jahre 1945, in dem das brandenburgische Landsberg an der Warthe eine plötzliche Metamorphose zum polnischen Gorzów Wielkopolski erfuhr. Das Schicksal dieser Stadt erscheint repräsentativ für die Geschichte von Orten, die nach dem Zweiten Weltkrieg infolge der Grenzverschiebungen ihre Identität verändert haben. Im Beitrag werden sogenannte Prä-Narrative dargestellt, d.h. Erzählbausteine, die sich in ephemeren Texten aus dem ‚Grenzgebiet des Augenblicks‘ entdecken lassen und die mit der Kreierung eines kollektiven Bildes des jeweiligen Ortes zusammenhängen. Diese Prä-Narrative sind ein Beitrag zur Geschichte der Beziehungen zwischen Menschen aus drei Kulturen: der deutschen, der polnischen und der russischen. Im Aufsatz werden die Fallstudien und die Metasprache aus der Monographie von Katarzyna Taborska Literatura miejsca. Piśmiennictwo postlandsberskie [‚Literatur des Ortes. Das post-landsbergische Schrifttum‘], Gorzów Wielkopolski 2017, aufgegriffen.
„… daß ‚Friedensschluß‘… nur eine Haltestelle von der Elektrischen ist“. Margarete Boie (1880–1946) in der „Inneren Emigration“
Authors: Preuß Werner H.
Published: May 2020

Der Beitrag beleuchtet das Phänomen „Innere Emigration“ paradigmatisch am Beispiel der Romanschriftstellerin Margarete Boie (1880–1946), die familiäre Beziehungen zu Danzig hatte und einen Teil ihres Lebens dort verbracht hat. Im Ersten Weltkrieg machte sie als Zeitungsredakteurin bereits Erfahrungen im Umgang mit der Zensur. Während des Nationalsozialismus versteckte sie sich hinter der Rolle der unpolitischen, aber konservativen älteren Offizierstochter. Anhand ausgewählter Geschichten aus ihrem Band Die Tagfahrt der Preußen (1942), der Erzählung Übers Jahr… (1944) und des nicht veröffentlichten Textes Zwei Tage in Berlin (Januar 1944) erörtert der Beitrag die Bedingungen und Möglichkeiten des Schreibens in der „Inneren Emigration“.
Princípio da autonomia privada, negócios processuais e os poderes do juiz Luiz Carlos de Assis Junior
Authors: Assis Junior Luiz Carlos de
Published: May 2020

O princípio da autonomia privada é a norma que confere à pessoa o direito de autodeterminação nos limites legais e constitucionais. Este princípio, outrora limitado à esfera das relações sociais no direito privado, vem sendo reconhecido com normatividade também na seara processual por meio dos negócios processuais. Isso restou evidente a partir do artigo 190 do CPC-15 e trouxe à tona o seguinte problema: Qual a situação jurídica do juiz frente a um negócio processual? Para responder a este problema, o artigo diferencia as hipóteses nas quais o negócio jurídico processual (i) não influencia emsitu¬ação jurídica titularizada pelo juiz, daquelas nas quais (ii) o negócio jurídico processual influencia na situação jurídica do juiz. Ao final, conclui que (i) em se tratando de negócio jurídico processual que não diz respeito à situação jurídica do próprio juiz, não se exige sua vontade para aperfeiçoamento do negócio e o controle por ele exercido será de verificação dos requisitos de validade e consonância com o próprio ordenamento jurídico como condição para efeitos endoprocessuais, mas (ii) se o negócio afetar a situação jurídica do magistrado, sua atuação será necessária para integrar os próprios requisitos de validade do ato, caso em que haverá negócio processual plurilateral, cuja validade exige a manifestação de vontade válida das partes e do magistrado.
Descarte de medicamentos:
Authors: Soares Paula Andrea Oliveira , Rosa Caroline Caribé Nolasco
Published: May 2020

O objetivo deste estudo é analisar a literatura que discorre sobre os impactos ocasionados à saúde pública pelo descarte de medicamentos, bem como o conhecimento da população acerca do respectivo assunto, a partir de uma pesquisa bibliográfica desenvolvida com base em material já elaborado, constituído principalmente de livros, artigos científicos e fontes como ANVISA. Segundo os dados, a maior parte da população tem o costume de descartar os medicamentos de forma incorreta, descartando-os em locais inadequados como lixo comum, pia, vaso sanitário e outros, possivelmente pelo fato denão haver nenhuma informação sobre a forma correta de descarte por parte dos órgãos competentes. Quando descartados de forma inadequada, os medicamentos podem causar graves impactos à saúde e ao meio ambiente. Conclui-se, portanto, que é premente a conscientização da população e a implementação de programas que visem minimizar a geração desses resíduos.
Incidência de sífilis em gestantes atendidas nas unidades de saúde no município de Teixeira de Freitas, Bahia
Authors: Siepierski Filho Stanislau , Rosa Caroline Caribé Nolasco , Nascimento Bruno Alves
Published: May 2020

O objetivo desse estudo foi relatar a incidência da sífilis em gestantes, além de verificar os dados epidemiológicos e perinatais, destacando a importância da qualidade da assistência pré-natal, no município de Teixeira de Freitas - Bahia, no período de Janeiro de 2013 a Junho de 2016, a partir de um estudo epidemiológico de caráter descritivo, com levantamento de dados secundários e abordagem quantitativa e qualitativa. A população estudada foi composta por 212 casos de notificação de sífilis em gestantes, registrados no Sistema de Informação de Agravos de Notificação (SINAN) na vigilância epidemiológicade Teixeira de Freitas – Bahia. As gestantes analisadas foram predominantemente de cor parda, apresentando ensino fundamental, com faixa etária entre 21 a 30 anos. Em relação ao acompanhamento pré-natal, observou-se predomínio do diagnóstico tardio e a totalidade dos tratamentos foi considerada inadequada, segundo o Ministério da Saúde. Diante disso, conclui-se que a qualidade da atenção pré-natal deve ser reestruturada.
Nível de fragilidade em idosos do município de Alcobaça, BA
Authors: Soares Paula Andréa Oliveira , Ramos Euriciane Rocha , Pinto Elis Regina Alves
Published: May 2020

Fragilidade é uma síndrome biológica de redução da reserva e resistência para estressores. No Brasil a mesma é pouco conhecida, pois é considerada um tema recente. Posto isso, o presente estudo tem como objetivo mensurar o nível de fragilidade em idosos do município de Alcobaça, Ba, para identificação de idosos: frágeis, pré-frágeis e não frágeis, segundo o modelo proposto por Linda Fried. A população foi composta por 114 idosos acima de 60 anos, sendo que 50,88% da amostra foi considerado frágil, 40,35% pré-frágil e 8,77% não frágil. Em relação à predominância do ser frágil, o marcador determinantefoi a falta de exercício físico. Diante disso conclui-se que a atividade física é de uma importância na vida do ser idoso.
Oilseed radish in single- and multi-crop sowings with poaceous crops
Authors: Andreeva O. T. , Pilipenko N. G. , Sidorova L. P. , Kharchenko N. Yu.
Published: May 2020

The results of field and laboratory research for 2015–2017 are presented and analyzed on the cultivation of traditional and uncommon poaceous crops. Recognized varieties of barley, oats, and millet were studied in single-crop sowings and intercropped with a high-protein cabbage crop – oilseed radish. The research was conducted on meadow chernozem mealy-carbonate soil in the forest-steppe zone of Trans-Baikal Territory. Agricultural technology used for fodder crop cultivation was common for this area. The objects of the research were the following varieties: barley Anna, oats Metis, millet Bystroe, oilseed radish Tambovchanka. The experimental work was carried out in accordance with the generally accepted guidelines for field experiments. Poaceous crops and oilseed radish were assessed in terms of their adaptability to growing conditions and their economically valuable characteristics that ensure sustainable production of high-energy feed. In multi-crop agrocenoses of poaceous crops and oilseed radish, the yield increased and the quality of feed raw material improved. The best results of multi-crop sowings were achieved by oats and millet intercropped with oilseed radish. The yield of green mass was 38.8-39.7 t/ha, dry matter content – 4.88-4.90 t/ha, digestible protein – 810820 kg/ha, and gross energy – 46.3-52.2 GJ/ha with availability of digestible protein – 180-186 g per one feed unit. Multi-crop sowings of oats and millet with radish oilseed are more productive than single-crop poaceous agrocenoses in feed units by 1.5-1.7 times, digestible protein by 2.9-3.3 times, gross energy by 1.2-1.6 times, with 10.5-10.7 MJ of exchangeable energy in one kilogram of dry matter.
A SURVEY OF CONSUMERS' PURCHASE INTENTIONS IN ADVERTORIALS PROMOTION IN COMMUNITY BUSINESS
Authors: Lin Li-Wei , Yan Su-Rong , Zhou Jia-Lu , Kaluri Rajesh
Published: May 2020

Soft text promotion and planning has become one of the key factors in attracting consumers' purchase intentions. Soft text promotion includes the use of posters, videos, online live broadcasts and other related methods to achieve consumer purchase intentions. The most important part of community business is to establish a long-term partnership between buyers and sellers through these soft-text promotion methods. This paper is expected to issue 600 copies through questionnaires to see if consumers see the promotion of soft texts into purchase motives. Or the consumer in the purchase process, fancy a sense of identity with a certain brand. We have found that consumers are promoting their activities through soft papers, resulting in direct purchase intentions. The results show that consumers will look at the introduction of soft paper promotion and share information with other consumers. These factors will cause consumers to motivate to purchase intentions.
Respon Pertumbuhan Bibit Panili (Vanilla planifolia Andrews) terhadap Aplikasi Zat Pengatur Tumbuh dan Pupuk Cair NPK
Authors: Yudha Aulia , Hariyadi .
Published: May 2020

Percobaan ini dilakukan untuk menentukan konsentrasi yang tepat pada zat pengatur tumbuh auksin dan pupuk cair NPK serta pengaruhnya terhadap pertumbuhan setek batang panili. Percobaan ini dilaksanakan di Kebun Masyarakat Sindang Barang, Bogor pada bulan Maret–Juni 2014. Percobaan menggunakan rancangan kelompok lengkap teracak (RKLT) dengan dua faktor yang diulang sebanyak tiga ulangan. Faktor pertama adalah konsentrasi auksin sebanyak tiga taraf, 0 ppm (R0), 1 000 ppm (R1), dan 2 000 ppm (R2) sedangkan faktor kedua adalah konsentrasi pupuk cair NPK sebanyak 6 taraf, 0 ppm (P0), 250 ppm (P1), 500 ppm (P2), 750 ppm (P3), 1 000 ppm (P4), dan 1 250 ppm (P5). Hasil penelitian menunjukkan bahwa konsentrasi auksin sebesar 2 000 ppm mampu menghasilkan pertumbuhan bibit yang lebih baik dibandingkan dengan konsentrasi lainnya sedangkan konsentrasi pupuk cair sebesar 0 sampai 1 250 ppm tidak ada yang berpengaruh nyata pada seluruh peubah pengamatan.
KECERDASAN, RELIGIUISTAS, KECINTAAN TERHADAP UANG DAN PERSEPSI ETIS MAHASISWA AKUNTANSI UNIVERSITAS AHMAD DAHLAN YOGYAKARTA
Authors: Lutfi Abdurahman Nurhuda , Hidayatulloh Amir
Published: May 2020

Tujuan penelitian ini adalah untuk menganalisis pengaruh kecerdasan intelektual, kecerdasan emosional, kecerdasan spiritual, religiusitas, dan kecintaan pada uang terhadap persepsi etis mahasiswa program studi Akuntansi. Populasi penelitian ini adalah mahasiswa Universitas Ahmad Dahlan. Sampel dalam penelitian ini adalah mahasiswa program studi Akuntansi. Teknik pengambilan sampel dalam penelitian ini menggunakan purposive sampling, dengan kriteria mahasiswa program studi Akuntansi yang sudah mengambil mata kuliah Pengauditan I dan Pengauditan 2. Pengumpulan data dalam penelitian ini dilakukan dengan menyebarkan kuesioner kepada responden yang memenuhi kriteria. Responden penelitian berjumlah 86 responden. Teknik analisis data dalam penelitian ini menggunakan analisis regresi linear berganda dengan bantuan alat SPSS. Penelitian ini memperoleh hasil bahwa persepsi etis mahasiswa program studi Akuntansi dipengaruhi oleh kecintaan pada uang (love of money). Sedangkan, kecerdasan intelektual, kecerdasan emosional, kecerdasan spiritual dan religiuistas tidak berpengaruh terhadap persepsi etis mahasiswa
AKUNTANSI PERSPEKTIF USAHA MIKRO KECIL MENENGAH (SURVEI PADA UMKM DI KOTA MATARAM)
Authors: Hilendri Bq. Anggun , Sapto Hendri BS  , L. Takdir Jumaidi  , D. Tialurra Della Nabila
Published: May 2020

Accounting information has an important role to achieve business success, including for small businesses. Accounting information can be a reliable basis for decision-making in managing small businesses, including market development decisions, pricing and others. The purpose of this study was to determine the perspectives of MSMEs owners about the accounting and financial management of their businesses. Based on the research results, perspective accounting MSMEs owners in the Mataram city is limited by income record and expenditure only or simple bookkkeeping. Financial management is done simply by knowing the initial capital has returned and the remaining results of operations are profit

Keywords: accounting, financial management
PENGARUH KINERJA PEMDA, KARAKTERISTIK PEMDA, DAN KARAKTERISTIK DEMOGRAFI TERHADAP IMPLEMENTASI E-GOVERNMENT (Studi Pada Pemerintah Daerah Tingkat Provinsi di Indonesia)
Authors: Bambang  , Pusparini Herlina , Nurabiah Nurabiah
Published: May 2020

Wujud nyata dari aplikasi e-government yang telah umum dilaksanakan dan diatur pelaksanaannya adalah pembuatan situs web pemerintah daerah. Situs web pemerintah daerah merupakan salah satu strategi didalam melaksanakan pengembangan e-government secara sistematik melalui tahapan yang realistik dan terukur. Situs web pemerintah daerah merupakan tingkat pertama dalam pengembangan e-government di Indonesia yang memiliki sasaran agar masyarakat Indonesia dapat dengan mudah memperoleh akses kepada informasi dan layanan pemerintah daerah, serta ikut berpartisipasi di dalam pengembangan demokrasi di Indonesia dengan menggunakan media internet. Penelitian ini bertujuan untuk menguji secara empiris pengaruh kinerja pemda terhadap implementasi e-government, pengaruh karakteristik pemda terhadap implementasi e-government, dan pengaruh karakteristik demografi pemda terhadap implementasi e-government.

Populasi dalam penelitian ini adalah pemerintah provinsi di Indonesia. Adapun sampel dalam penelitian ini dipilih berdasarkan kriteria. Kriterianya adalah  pemerintah daerah tingkat provinsi yang masuk dalam indeks PeGi selama tahun 2014 – 2015. Sumber data yang digunakan dalam penelitian ini adalah data sekunder. Metode analisis data menggunakan SmartPLS versi 3.2.6. Hasil penelitian ini menunjukkan bahwa kinerja pemda berpengaruh terhadap implementasi e-goverment sedangkan karakteristik pemda dan karakteristik demografi tidak berpengaruh  terhadap implementasi e-government.
PENGARUH PENAMBAHAN CACING SUTRA (Tubifex) SEBAGAI KOMBINASI PAKAN BUATAN TERHADAP EFISIENSI PEMANFAATAN PAKAN DAN PERTUMBUHAN LARVA IKAN LELE SANGKURIANG (Clarias gariepinus)
Authors: Mullah Atta , Diniarti Nanda , Astriana Baiq Hilda
Published: May 2020

Ikan lele (Clarias sp.) merupakan salah satu komoditas air tawar unggulan untuk dibudidayakan dan digemari di kalangan masyarakat. Hal ini dikarnakan nutrisi yang dimiliki ikan lele mengandung protein yang tinggi dan zat penguat tulang (kalsium) yang baik untuk makanan. Ikan lele termasuk dalam golongan ikan karnivora dan juga termasuk hewan pemakan bangkai, pada fase larva ikan lele sangat membutuhkan pakan alami seperti cacing sutra (Tubifex) yang memiliki nilai protein yang tinggi. Penelitian ini dilaksanakan selama 30 hari dari Tanggal 31 Juli 2019 sampai Tanggal 29 Agustus 2019, tempat penelitian dilaksanakan di Desa Langko, Kecamatan Lingsar, Kabupaten Lombok Barat. Penelitian ini dilakukan dengan metode eksperimental menggunakan Rancangan Acak Lengkap (RAL) dengan empat perlakuan dan tiga ulangan yaitu perlakuan A: Pelet 100% (kontrol), B : Pelet 25% dan Cacing Sutra 75%, C : Pelet 50% dan Cacing Sutra 50% dan D : Pelet 75% dan Cacing Sutra 25%. Hasil penelitian menunjukkan bahwa tingkat kelangsungan hidup (SR) larva ikan lele sangkuriang (Clarias gariepinus) tertinggi diperoleh pada perlakuan B yaitu mencapai 94,7% dan nilai kelangsungan hidup terendah pada perlakuan A yaitu sebesar 80%. Hasil ANOVA menunjukan ada perbedaan signifikan dari pengaruh penambahan cacing sutra sebagai kombinasi pakan buatan untuk pemeliharaan terhadap pertumbuhan berat mutlak, pertumbuhan panjang mutlak, tingkat kelangsungan hidup, efisiensi pemanfaatan pakan (EPP) dan waktu pengosongan lambung. Perlakuan terbaik diperoleh perlakuan B (Pelet 25% dan Cacing Sutra 75%).