bluuebunny/crossref_metadata_2025 huggingface dataset:
A Computational Exploration of Whole Genome Sequences of Klebsiella pneumoniae ST16 for Beta-lactam Resistance and the Discovery of NMD-1 Resistance Gene Inhibitor
Authors: Ibisanmi Tope Abraham , Olowosoke Christopher Busayo , Ayeni Timothy O. , Faleti Ayodele Ifeoluwa
Published: October 2023

Antibiotic resistance is a growing concern in healthcare and medicine. This research focuses on studying the sequences of Klebsiella pneumoniae ST16 from the NCBI database. The goal is to identify genes that cause resistance to antibiotics and potentially find substances that can inhibit them. The study discovered genes that contribute to resistance against types of antibiotics such as macrolides, fluoroquinolones, aminoglycosides, sulphonamides, rifampicin, trimethoprim, and beta-lactams. Notable genes identified include blaTEM 1B, blaCTX M 15, and blaNDM-1. Furthermore, changes were observed in the acrR, ompK36, and gyrA genes, along with alterations in the corresponding acids, which are associated with resistance. The analysis also examined the alleles at each locus and found that FIA had a new allele. Molecular docking results revealed that baicalein showed docking scores of -7.7 kcal/mol when binding with New Delhi Metallo 1 (NDM-1) related to beta-lactams. The RMSD plot demonstrated behavior for both Baicalein and Adapalene complexes of NDM-1 over a 50 ns simulation period. However, the higher Rg value for the NDM-1 Beta-Lactamase 1-Adapalene complex indicates it may have slightly more flexibility compared to the NDM-1 Beta-Lactamase 1-Baicalein complex. Summarily, the study offers information about how antibiotic resistance works in relation to the NDM-1 gene and its role in beta-lactam resistance based on analysis which reveals that beyond baicalein, other excellent bioactive (taxifolin, and ellagic acid) strongly bind to the NDM 1 domain and can be further investigated experimentally.
Water-Dissociation Catalysis Near the Reversible Limit in Bipolar Membrane Electrolyzers
Authors: Boettcher Shannon ,   Sayantan Sasmal1, Chen Lihaokun , Sarma Prasad , Traenkle Olivia , Simons Casey , Wells Kacie , Spontak Richard
Published: October 2023

The voltage penalty encountered when driving water dissociation (WD) at a high current density represents a major obstacle in the commercialization of existing bipolar-membrane (BPM) technology for energy devices. Here we show that three materials descriptors, including the electrical conductivity, microscopic surface area, and (nominal) surface-hydroxyl coverage, effectively control the kinetics of WD in BPMs. Using these descriptors and optimal mass loading, we design new earth-abundant WD catalysts based on nanoparticle SnO2 synthesized at low temperature that exhibit exceptional performance by driving the WD reaction in a BPM electrolyzer at the remarkably low WD overvoltage (ηwd) of 100 ± 20 mV at 1.0 A cm−2. We demonstrate this new catalyst works equivalently well with hydrocarbon proton-exchange layers as it does with fluorocarbon-based Nafion, thus providing new pathways to commercializing advanced bipolar membranes for a broad array of electrolysis, fuel-cell, and electrodialysis applications.
Enhancement of tripartite entanglement via periodically-modulated fields with an atom-assisted optomechanical system
Authors: Wen Jiaxin , LU Yi , Li Zhenghong , Yang Xihua
Published: October 2023

We propose a model for controlling and enhancing the entanglement between the two cavity fields and mirror with a hybrid optomechanical system consisting of Λ-type three-level 85Rb atomic ensembles driven by two externally modulated laser fields. When one (another) cavity mode is driven at the red (blue) mechanical sideband and both cavity modes are blue-detuned by the mechanical frequency to the respective atomic resonant transitions, the dynamic coupling control of the cavity field and mirror can be realized by periodically modulating the amplitudes of the two incident laser fields. Compared to the unmodulated case, the periodic modulation of the laser fields in a cavity-optomechanical system embedded with a small number of atoms has the capability to enhance the entanglement between the two cavity fields and mirror. This scheme provides a new approach to the generation and control of entanglement in cavity-optomechanical systems.
An Assessment of Sociotechnical Transition in Marine Warranty Survey Practice: Case of West Africa’s Marine and Cargo Project Management Against Risk
Authors: Sackey Anthony D. , Lamptey Benjamin L. , Afful Priscilla A. , Barwuah Kwasi G. , Amoak Steven , Sackey Barbara K. , Amedake Marilyn A.Y. , Obuya Ojulu N. , Eshun Isaac , Nyarko Enock Otoo , Obeng-Adjapong Felix
Published: October 2023

As in Figure 1, the study proceeds to investigate and characterize the nature of the sociotechnical systems and transitions during operation in the maritime industry spared by the COVID-19 pandemic –comparing and examining cause and effect variables setting forth the relationship of complexity within the transition in the Gulf of Guniea area. The study also examines and contrasts best practices while drawing on the lessons learned. A case study approach was implemented where initial data gathering was achieved through a targeted survey. This was followed by a select interview to examine specific concerns arising from the survey outcome before a field observation was carried out.
The study finds respondents highlighted the emerging need for green energy towards ecological sustenance as highly ranked among factors rapidly spearheading socio-technical transition in the maritime and offshore energy industry in West Africa. 67 percent also viewed the health crisis as a positive force in the sociotechnical transition in the maritime and offshore energy industry. These findings agreed with researchers who found that during the pandemic’s lockdown and restrictions, carbon emissions across the globe were reduced by 5.4 percent. Again, 87 percent found the need to be physically present on the survey site critical to safe operations and success. This notwithstanding, the period saw the introduction and scaling of remote marine surveys. Finally, 81.4 percent of respondents found the use of remote technology on the marine survey site to be essential to operations success while limiting the movement of the attending surveyor on site.
Interest rate law: how low wages makes the loanable fund Market a sustainable one
Authors: boughabi houssam
Published: October 2023

The fact Markets don’t lead to efficiency while there are more habits of speculating around currencies and interest rate is not taken as a lemma, this article embraces the classical doctrine, the interst rate is shown to increase if workers are pessimist about future wages E[wT /Ft ] = 0, arguably risk in the Stock market if we suppose it is fractional has more incentives for the loanable fund Market while it remains to be seen for what reason interest rate has come through risky assets to define a benchmark for wealth
JEL Classification. B21, E41
PINN-CHK: Physics-informed neural network for high-fidelity prediction of early-age cement hydration kinetics
Authors: Rahman Md Asif , Zhang Tianjie , Lu Yang
Published: October 2023

Cement hydration kinetics, characterized by heat generation in early concrete stages, poses a modeling challenge. This study introduces the Physics-Informed Neural Network for Cement Hydration Kinetics (PINN-CHK) to investigate early-age temperature rises in cement paste. PINN-CHK leverages data-driven solutions to craft a high-fidelity prediction model, encompassing material properties and maturity functions in cement hydration. Trained on heated cement paste data, it simultaneously fits experimental results and underlying physics, yielding a mesh-free simulation. Incorporating governing partial differential equations, initial and boundary conditions into its loss function, PINN-CHK architecture undergoes rigorous benchmark testing, demonstrating unparalleled predictive accuracy compared to conventional deep learning methods. It excels in forecasting complete temperature fields during spatial-temporal cement hydration, achieving a remarkable relative L2 error as low as 0.00341. PINN-CHK achieves exceptional convergence and accuracy with only 5% of the training data, ushering in a new era in this crucial field. This innovative approach bridges the gap between theory and practice, offering an attractive alternative to conventional finite element solvers for enhanced comprehension of cement hydration kinetics and concrete maturity and strength development in cement-based materials.
Effect of direct-contact ultrasonic-infrared combined drying on the drying characteristics and quality of ginger
Authors: Feng Zhenhua , Zhang Minmin , Guo Lanping , Shao Rencai , Wang Xiao , Liu Feng
Published: October 2023

In this study, direct-contact ultrasonic-infrared combined drying method was used to dry the ginger, including the water loss process, color difference, water migration law, gingerol content, volatile components and antioxidant activity of ginger under different ultrasonic frequencies, drying temperatures and slice thicknesses. The results of low field nuclear magnetic resonance (LF-NMR) and gas phase ion migration chromatography (GC-IMS) analysis showed that compared with single infrared drying, ultrasonic combined with infrared drying accelerated the free water migration rate, shortened the drying time (from 280 min to 160 min), and reduced the loss of gingerol and volatile components in ginger. After ultrasonic intervention, the natural active ingredients and antioxidant activity of the samples were significantly increased (p < 0.05). The results of weighted comprehensive scoring showed that the infrared temperature of 50 °C and the ultrasonic frequency of 21 KHz were the optimal parameters for the direct-contact ultrasound-infrared combined drying of ginger slices, and the overall quality of ginger slices was the best under these conditions. This drying technology has certain reference significance for the drying process of ginger slices.
Energy dependence of GafChromic LD-V1 film dose response to X-ray photons in the 60 to 180 kV range
Authors: Mbewe Jonathan
Published: October 2023

Introduction
Radiochromic film (RCF) is suitable for use as a dosimeter because of its inherently superior spatial resolution and near water-equivalence. A new model of RCF recommended for measuring imaging dose in the kV nominal energy range was recently introduced onto the market. In this study, we investigate the dependence on beam quality of GafChromic LD-V1 film's radiation dose response.
Material and methods
Pieces of LD-V1 film were irradiated to air kerma ranging from 0 to 570 mGy in X-ray photons with beam qualities of 60 kV (HVL = 1.32 mm Al), 100 kV (HVL = 2.83 mm Al), 120 kV (HVL = 5.11 mm Al), 150 kV (HVL = 6.23 mm Al), and 180 kV (HVL = 0.54 mm Cu). The net reflectance from each film was obtained from a color flatbed scanner. For each beam quality, an analytical power function was fitted to the net reflectance - air kerma relationship and tested for differences.
Results
We have found that for the beam qualities investigated, the response of Gafchromic LD-V1 film was not significantly dependent on energy, and a single dose - net reflectance calibration curve could be used to model the response at all beam qualities. The total relative uncertainty and absolute error reached maxima of 18% and 80%, respectively for air kerma values less than 50 mGy, but remained below 10% for air kerma in the range 50 mGy to 570 mGy.
Conclusions
The results of our investigation revealed that the response of Gafchromic LD-V1 film is not significantly dependent on beam quality. A minimum air kerma irradiation of 50 mGy is recommended to minimise uncertainty.
Georg Adam, 1874–1948
Authors: Randow Norbert
Published: October 2023

Dieses Porträt über Georg Adam gibt einen Vortrag wieder, den Norbert Randow (1929–2013) am 18. November 1960 anlässlich der 150-Jahr-Feier der Humboldt-Universität zu Berlin gehalten hat. Gedruckt erschien der Beitrag 1962 in der "Wissenschaftlichen Zeitschrift" der Humboldt-Universität unter dem Titel "Der Slawenfreund Georg Adam und sein Verhältnis zur bulgarischen Literatur". Die am Schluss des Vortrags angekündigte größere Studie zu Leben und Werk Georg Adams kam nicht zustande, da Randow 1962 wegen "Beihilfe zur Republikflucht" zu einer mehrjährigen Haftstrafe verurteilt wurde und anschließend seine slawistisch-bulgaristischen Forschungsvorhaben nicht wieder aufnehmen konnte. Stattdessen wurde er - seinem großen Vorbild Georg Adam folgend - herausragender Übersetzer aus slawischen Sprachen, insbesondere aus dem Bulgarischen und Weißrussischen. Der von Norbert Randow in den 50er Jahren übernommene Nachlass Georg Adams ist in großen Teilen Bestandteil des an die Humboldt-Universität gelangten Randow-Nachlasses, ein kleinerer Teil Korrespondenz ist an das Bulgarische Literaturarchiv in Sofia gegangen.
Regine Adler, 1870–1943
Authors: Czier Uwe
Published: October 2023

Regine Adler teilte das Schicksal vieler Frauen aus dem Umfeld der Prager Deutschen Literatur: Sie stand im Schatten ihres literarisch erfolgreichen Gatten Friedrich Adler, obwohl sie eigene Werke veröffentlichte und auch als Übersetzerin hervortrat. Außer grundlegenden biografischen Daten ist über ihr Leben bisher nur wenig bekannt.
Alfred Andersch, 1914–1980
Authors: Czier Uwe , Primus Dora
Published: October 2023

Alfred Andersch gehört, wenn auch nicht gänzlich unumstritten, zu den kanonisierten Autoren der westdeutschen Nachkriegsliteratur. Daneben hat er einige Übersetzungen erstellt, die jedoch von der Forschung bisher kaum beachtet wurden.
Hilde Angarowa : Übersetzungsbibliographie
Authors: Tretner Andreas
Published: October 2023

Die Titel der folgenden Bibliographie wurden überwiegend autoptisch erfasst. Primärquelle war die Belegbibliothek, die die Übersetzerin als Teil-Nachlass der Stadtbibliothek ihrer Heimatstadt Cottbus übereignet hat. Hilfreich waren ferner: Katalog der Deutschen Nationalbibliothek (DNB), "Literatur in der SBZ/DDR. Bibliografische Annalen 1945-1990" sowie mehrere persönliche Bibliografien der Übersetzerin: 1) "Verzeichnis meiner wesentlichen Arbeiten" (Перечень моих основных работ), Ts. 2 S., russ. mit hs. Korrekturen und Ergänzungen zum 07.04.1951, im Bremer Nachlass, Forschungsstelle Osteuropa (BHA1951); 2) "Bücherliste", o. D., Ts. 3 S., dt. mit hs. Ergänzungen, ca. 1960er, ebd. (BHAoD); 3) "Buchausgaben", Ts. 4 S., dt., im Cottbuser Nachlass (BHA1988); 4) "Übersetzungen, erschienen in 'Internationale Literatur' und 'Sowjetliteratur'", Ts. 5 S., dt., um 1988, ebd. (BHASL1988). In der Kategorie "Sonstige Übersetzungen" werden veröffentlichte Titel genannt, bei denen eine Zuschreibung der Verfasserschaft von Hilde Angarowa bestritten wird (Fadejew), ferner solche, bei denen sie hergestellt bzw. nahegelegt wird (Wasilewska) sowie schließlich "Zwischenfälle" (Furmanow). Darüber hinaus werden Übersetzungen gelistet, die in den Archivdokumenten erwähnt werden, aber weder als Typoskript, noch als veröffentlichter Text vorliegen.
Erich Arendt : Bibliographie
Authors: Vejmelka Marcel
Published: October 2023

Die Bibliographie verzeichnet die in Einzelausgaben (einschl. Nachauflagen, Neuausgaben und Lizenzausgaben) sowie die in Anthologien und Zeitschriften veröffentlichten Übersetzungen, in Einzelfällen zusätzlich die jeweils verwendeten Originalausgaben. Literarische Werke von Erich Arendt sind nicht berücksichtigt, nur Publikationen mit Bezug zu seinen Übersetzungen, meist Vor- und Nachworte. An Sekundärliteratur ist erfasst, was explizit Bezug auf Erich Arendt als Übersetzer nimmt bzw. für sein übersetzerisches Handeln oder anderweitig für den Blick auf den Übersetzer relevant ist.
Detection of the landing site and development of algorithms for automatic landing of an unmanned aerial vehicle
Authors:   Tomsk State University of Control Systems and Radioelectronics (TUSUR), Korikov Anatoly M. , Tran Van Тruc ,   Tomsk State University of Control Systems and Radioelectronics (TUSUR)
Published: October 2023

In the article, for a dual-circuit navigation and control system (NKS) of an unmanned aerial vehicle (UAV), the following tasks are solved: detection (recognition) of a landing pad (LP) for a UAV using a convolutional neural network; determining the coordinates of the LP in the frame of the UAV camera; tracking the LP in the frame through the channels of roll, yaw and pitch of the UAV triaxial gimbal; simulation of the UAV flight in space along a given trajectory and automatic landing of the UAV on the detected LP; synthesis of sliding control by the positional and angular coordinates of the UAV. MATLAB SIMULINK software was used to implement the developed algorithms for solving these problems. The created algorithms provide automatic landing of the UAV on the detected LP.
GESTIÓN ADMINISTRATIVA Y EL TALENTO HUMANO: EMPRESA PÚBLICA DE AGUA POTABLE Y ALCANTARILLADO, CANTÓN JIPIJAPA
Authors: Proaño Ponce William Patricio , Capurro Choez Rosa Estefanía
Published: October 2023

Esta investigación nace con el objetivo de analizar el talento humano y la gestión administrativa para identificar el desempeño laboral en la Empresa Pública Municipal de Agua Potable y Alcantarillado Sanitario del Cantón Jipijapa (EPMAPAS), con el propósito de comprobar la aplicación de las regulaciones de gestión interna a los procesos de selección de talento humano (TTHH). Esta entidad se encarga de proveer servicios de agua potable tanto en áreas urbanas como rurales del cantón y sus parroquias aledañas, cabe destacar que esta Empresa Pública se financia mediante las recaudaciones mensuales de los usuarios del servicio. Las conclusiones de esta investigación señalaron que el 83.5% del personal de la empresa tienen competencias desarrolladas por la unidad del talento humano, de igual forma el 60.4% de los miembros consideran que el modo de administración de talento humano ayuda a optimizar el rendimiento del equipo, lo que genera un buen ambiente laboral y una aplicación eficiente de las normas de control que han permitido realizar de excelente manera la selección del talento humano. La metodología aplicada en esta investigación se enfocó en la combinación de dos aspectos, el primer enfoque hizo referencia a los datos cualitativos, mediante la recopilación y evaluación de información subjetiva, como segundo enfoque a través de la encuesta se seleccionó información cuantitativa. Así mismo, se utilizó una fuente primaria de información con datos bibliográficos, permitiendo combinar la extensión y la abundancia de la información cualitativa con la precisión y la generalización de los datos cuantitativos.
PROCEDIMIENTOS POR ÍNFIMA CUANTÍA EN LA CONTRATACIÓN PÚBLICA DE LOS GOBIERNOS AUTONÓMOS DESCENTRALIZADOS PROVINCIALES
Authors: Quiñónez Cercado Mónica del Pilar , Calle García Aldrin Jefferson , Calle García Jonás Sneider
Published: October 2023

El propósito de este trabajo investigativo se enfocó en el estudio de cinco informes auditados por la Contraloría General del Estado, respecto al proceso de ínfima cuantía en la contratación pública de los Gobiernos Autónomos Descentralizados (GAD) Provinciales, relacionándolo con normativa aplicable para la sistematización de este proceso que involucran a todos los servidores que participan en el desarrollo para obtener bienes, obras y servicios, los cuales también abarcan la reparación, mantenimiento o la optimización de una edificación o estructura previamente establecida. La Ley Orgánica del Sistema Nacional de Contratación Pública (LOSNCP), es quién regulariza a todas las entidades públicas. Además, el Servicio Nacional de Contratación Pública (SERCOP), cumple la función de ser la máxima autoridad en compras públicas, supervisando el correcto procedimiento determinado en su Reglamento, el cual detalla cómo deben llevarse a cabo los procesos de contratación pública. La Resolución No. RESERCOP-2016-0000072 representa el proceso detallado para los convenios de ínfima cuantía. Todas aquellas normas mencionadas fueron inobservadas en varios de sus artículos, pudiéndose notar en los Gobiernos Provinciales de Esmeraldas, Guayas, Pichincha, Napo y Chimborazo. Se empleó una metodología fundamentada en el método descriptivo, dado que se analizó los informes finales y así mismo las normas que articulan esta temática, la cual proporcionó una representación objetiva y detallada de los datos observados.
COMPORTAMIENTO ORGANIZACIONAL Y LA TOMA DE DECISIONES: GOBIERNO AUTONÓMO DESCENTRALIZADO PARROQUIAL SABANILLA
Authors: Castro Lino Daniela Fernanda , Morán Chilán Jessenia Herminia
Published: October 2023

El comportamiento organizacional se centra en analizar las acciones y actitudes de las personas en un ambiente laboral, con el fin de mejorar la eficacia en la toma de decisiones para alcanzar los objetivos institucionales, en este sentido, este estudio logró determinar el comportamiento organizacional y su incidencia en la toma de decisiones del Gobierno Autónomo Descentralizado Parroquial de Sabanilla, cantón Pedro Carbo de la provincia del Guayas. Para ello se llevó a cabo una metodología mixta que combina enfoques cualitativos y cuantitativos, además del método descriptivo y correlacional, dado que se incluyeron encuestas dirigidas a una muestra de 52 funcionarios públicos. Entre sus resultados mas relevantes se destacó que el 79% de los encuestados consideraron la incidencia del comportamiento organizacional en la toma de decisiones como un aspecto fundamental, no obstante, se observó un bajo nivel de conocimiento sobre las dos variables de esta temática planteada.
CULTURA TRIBUTARIA Y PAGO DE TRIBUTOS EN LA ASOCIACIÓN DE PRODUCCIÓN AGROPECUARIA LAS LAGUNAS ASOPROAGLA
Authors: Quiñónez Cercado Mónica del Pilar , Villegas Flores Fabiola Masiel
Published: October 2023

La cultura tributaria es esencial en la recaudación fiscal y la viabilidad del sistema tributario nacional, es decir, se refiere a las actitudes, creencias y comportamientos que influyen en los contribuyentes para cumplir con sus obligaciones fiscales. Por lo tanto, este estudio tiene el propósito de determinar la incidencia de la cultura tributaria en el pago de tributos de la Asociación de Producción Agropecuaria las Lagunas (ASOPROAGLA), debido a que el desconocimiento del tema es un factor detrás del incumplimiento fiscal. La metodología empleada se fundamenta en un análisis correlacional, ya que se estudia la relación entre las variables de esta investigación, también se realiza un enfoque cualitativo y cuantitativo para indagar en la cultura tributaria y el nivel de conocimiento de los socios, y además de ejecutar la técnica de la encuesta aplicada a los 24 socios. Los resultados revelan que el 54% cree que el cumplimiento tributario beneficia la reputación de ASOPROAGLA, sin embargo, el 21% desconoce por completo la cultura tributaria, y el 79% tiene un conocimiento limitado. Se concluye que la mayoría de los miembros presentan escaso conocimiento en este ámbito, lo cual resalta la necesidad de educación y concienciación tributaria en la asociación. El bajo conocimiento señala la importancia de iniciativas de capacitación para fortalecer la comprensión y participación de los socios en temas fiscales.
CULTURA ORGANIZACIONAL EN EL DEPARTAMENTO DE RECURSO HUMANO DEL GOBIERNO AUTÓNOMO DESCENTRALIZADO AUTÓNOMO, CANTÓN CHONE
Authors: Saltos Delgado María Cristina , Marcillo Parrales Diana Victoria
Published: October 2023

La gestión administrativa implica la coordinación de diversas tareas y actividades con el objetivo de optimizar los recursos de las instituciones. Por esta razón, esta investigación se centró en analizar el proceso administrativo del departamento de talento humano en el Gobierno Autónomo Descentralizado del cantón Chone, además de analizar la situación actual de la institución e identificar los factores tanto internos como externos que influyen en la gestión del departamento de talento humano, así mismo, se evaluó la cultura organizacional en la gestión administrativa del mencionado departamento. Para llevar a cabo este estudio, se aplicó el método inductivo y deductivo, también el sintético-analítico, lo que llevaron a la conclusión de que el desempeño del departamento de recursos humanos contribuye significativamente a fortalecer la gestión administrativa en la institución. Los resultados obtenidos demuestran que la institución cumple con la mayoría de los elementos claves de la cultura organizacional, lo que garantiza que las actividades y procesos se desarrollen con legalidad y razonabilidad, generando así información confiable en el ámbito de la gestión administrativa.
PLANIFICACIÓN ESTRATÉGICA EN LA GESTIÓN OPERATIVA DEL CUERPO BOMBEROS, CANTÓN DAULE
Authors: Cabrera Mora Yaritza Pamela , Morán Chilán Jessenia Herminia
Published: October 2023

Esta investigación se centra en analizar la gestión operativa y su influencia en la planificación estratégica del Cuerpo de Bomberos del cantón Daule. Para lograr este objetivo, se identificaron los procesos de gestión operativa basados en los objetivos institucionales y se evaluó los procesos de planificación estratégica. En la metodología se emplearon tres tipos de investigación: bibliográfica, descriptiva y de campo, junto con métodos analíticos, deductivos, inductivos y estadísticos. Además, de que se realizaron encuestas tanto al personal administrativo como al operativo para obtener datos relevantes. Los resultados revelaron la falta de planificaciones anuales que aborden las capacitaciones físicas y mentales necesarias para las emergencias del Cantón Daule. No obstante, el 90% de los encuestados conocen de la misión, visión y los objetivos estratégicos de la entidad. También, se evidenció la necesidad de promover la socialización de los manuales internos del Cuerpo de Bomberos del Cantón Daule entre el personal.
CHEMICAL CONSTITUENTS AND EVALUATION OF ANTIPROLIFERATIVE AND ANTI-INFLAMMATORY ACTIVITIES FROM Psychotria schlechtendaliana (RUBIACEAE)
Authors: Corrêa José , de Moura Vagner , Ames Franciele , Bianchin Mirelli , Sebold Simone , Peixoto Matheus , Pomini Armando , de Carvalho João , Ruiz Ana , Bersani-Amado Ciomar , Santin Silvana
Published: October 2023

Phytochemical study of Psychotria schlechtendaliana (Rubiaceae) aerial parts resulted in the isolation of alkaloids 4-N-oxide harmane (1) and strictosidinic acid (2), and the terpenoids sitosterol, estigmasterol, α-amyrin, β-amyrin and betulinic acid. The crude extract (CE), its fractions (hexane FH, chloroform FC, ethyl acetate FEA, hydromethanolic FHM, alkaloidal chloroform FCOH, alkaloidal aqueous FAq) and majority alkaloid (1) were investigated for their antiproliferative potential against nine human tumor cells lines and one non-tumoral human cell line (HaCat). CE, FH and FEA fractions exhibited strong growth inhibition for ovary cells (OVCAR-3, GI50 = 5.89; 1.36 and 6.59 μg mL-1, respectively) and FC, FH and FAq fractions showed potent activity on the growth of leukemia cell lines (K562, GI50 = 1.92; 7.23 and 8.81 μg mL-1, respectively). Compound 1 exhibited selective antiproliferative activity to breast cancer (MCF-7, GI50 = 32.7 μg mL-1) and was non-toxic to HaCat cells. To evaluate the anti-inflammatory effect, models of ear edema induced by croton oil and the enzyme myeloperoxidase (MPO) were used. FH and FC fractions exhibited antiinflammatory effect and reduce ear edema compared to the control group. These fractions showed results superior to those exhibited by indomethacin (75.1%), FH (97.5%) and FC (95.5%) fractions.
Capillary Zone Electrophoresis with Diode-Array Detection as a Tool to Monitor Variations in the Concentration of Organic Acids from the Tricarboxylic Acid Cycle in Human Urine
Authors: Salvio Riani , Tolentino Hugo , Latini Alexandra , Ronsoni Marcelo , Micke Gustavo
Published: October 2023

The tricarboxylic acid (TCA) cycle is responsible for the generation of energy in the human body and may inform about the energy status in different physiological and pathological conditions. It was developed a method to quantify the TCA cycle intermediates (α-ketoglutaric, citric, fumaric, lactic, malic, and succinic acids) by capillary zone electrophoresis with diode array detector (CZE-DAD) in indirect mode. The background electrolyte consisted of 24 mmol L–1 2,6-pyridine carboxylic acid, 76 mmol L–1 β-alanine, and 4 mmol L–1 hexadecyltrimethylammonium hydroxide (pH 4). The method was validated and presented a good linearity (R2 > 0.9922) and adequate limits of detection (0.24-1.84 mg L–1) and quantification (0.74-5.57 mg L–1). The method was successfully applied to samples of individuals with obesity before being submitted to bariatric surgery and one year after the surgery. The citric, lactic, and malic acids were detected in the analyzed samples. To evaluate the changes in concentrations of the TCA intermediates, principal component analysis was carried out, and there was no significant difference between the two sets of samples. Altogether, the data obtained after applying this new method suggest that CZE-DAD could be used to detect and quantify the TCA cycle metabolites in human urine.
The threshold of toxicological concern for insufficiently explored chemicals occurring in drinking water during transportation
Authors:   Centre for Strategic Planning and Management of Biomedical Health Risks, 10 Pogodinskaya St., build. 1, Moscow, 119121, Russian Federation, Alekseeva A.V. , Savostikova O.N. ,   Centre for Strategic Planning and Management of Biomedical Health Risks, 10 Pogodinskaya St., build. 1, Moscow, 119121, Russian Federation
Published: October 2023

Finding solutions to issues of drinking water safety is a significant component in activities aimed at public health protection. In accordance with sanitary-epidemiological requirements, drinking water, in particular, should be harmless as regards its chemical composition and have favorable organoleptic properties. It is especially vital to identify risk factors for public health associated with drinking water quality. Supplying high-quality drinking water to population is a relevant problem associated, among other things, with use of new materials and reagents. The major challenge posed by their hygienic assessment is a potential growth in human health risks caused by consuming tap drinking water contaminated with migrating organic compounds. Although each of them has been detected in low concentrations, they can cause adverse chronic health outcomes. The Threshold of Toxicological Concern (TTC) is a powerful tool of risk assessment. It is based on identifying a threshold value of effects produced on human health by chemicals for which no hygienic standards have been developed so far. Below such a threshold, there is very low (95 %) likelihood of a health risk being higher than its acceptable levels. An idea of some exposure levels unable to cause adverse health outcomes is embedded in establishing maximum permissible levels (MPLs) for chemicals with known toxicological profiles. The TTC enlarges this concept by assuming that the minimum value can be identified for many chemicals based on their composition even if there is no comprehensive database on their toxicity. The TTC can be used for evaluating up-to-date materials applied in drinking water supply in order to detect risks for human health caused by consumption of drinking water that had contacts with them. Such risk assessment relies on the results of examining water extracts and involves identifying priority chemicals for their further investigation and control.
Electronic digital devices and a risk of functional disorders of the visual analyzer in students of different age
Authors:   Perm State Medical University named after Academician E. A. Wagner, 26 Petropavlovskaya St., Perm, 614000, Russian Federation, Riazanova E.A. , Lir D.N. ,   Perm State Medical University named after Academician E. A. Wagner, 26 Petropavlovskaya St., Perm, 614000, Russian Federation,   Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, 82 Monastyrskaya St., Perm, 614045, Russian Federation, Zagidullina D.Sh. ,   Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, 82 Monastyrskaya St., Perm, 614045, Russian Federation
Published: October 2023

The aim of our study was to perform hygienic assessment of use of electronic digital devices and its relationship with likely disorders of the visual analyzer in students of different age. Our research object is represented by students of different age (5th grade (n = 55), 11th grade (n = 67) and the 6th year of HEI (n = 102)). This study focused on examining a relationship between disorders of the visual analyzer and use of electronic digital devices (EDDs) by students of different ages (5th and 1th grades in school, 6th year in HEI). We conducted social research by using a group indirect survey that relied on a specifically designed questionnaire consisting of 13 questions. Answers were collected by using Google Forms online platform. Students were established to use a smartphone (99.6 % of the respondents) and / or laptop (83 %) in their everyday activities. We analyzed duration of an activity involving use of various devices and established that 95 % of the respondents did not adhere to the existing hygienic standards when using EDDs and spent more than 4 hours a day on using them. The regression analysis revealed an association between myopia development and simultaneous use of various EDDs (R2 = 0.68; р < 0.0001). A contribution made to developing eyesight disorders by working with a laptop equaled 62 % whereas contributions made by watching TV and use of smart-watch equaled 19 % and 10 % respectively. Our assessment of a relative risk established that use of a laptop (PC) for more than 4 hours a day increased likelihood of myopia by 8.6 times (RR = 8.6; 95 % CI = 1.4–54.9, р < 0.05). Development of other functional disorders in school students was primarily associated with watching TV (85–89 %). Therefore, our study findings provide more precise data on the established relationship between improper EDDs use and disorders of the visual analyzer in students of different age. They provide solid grounds for implementation of relevant prevention activities.
Monitoring the Quality of Financial Management of Governmental Bodies: Analytical and Management Aspects of Application
Authors: Alfimenko S. S.
Published: October 2023

One of the main results of reforming the budget process of the Russian Federation in the middle of the 2000s was the widespread implementation of the approach to the work of the executive power, in which budget funds are allocated in accordance with the expected results. Performance indexes are necessarily developed for government programs, national projects, and other strategic planning documents. Finally, monitoring by indexes is increasingly being used as a tool for evaluating the performance of executive authorities and officials. Is this approach expedient in any case? Is it always possible to use monitoring by indexes as a basis of the performance evaluating system for civil servants?

This study considers the feasibility of including the results of assessing the quality of financial management of budget managers in the system of indexes for assessing the activities of executive bodies of state power of the Russian Federation constituent entity.

The study is focused on distinctive features of monitoring the financial management quality of budget funds’ managers, which make it difficult to use for a sound judgment about the efficiency of the participants of the budget process. In the course of the study, an analysis was carried out by the method of comparison and correlation of Pearson using data from the following sources: the official website of the Committee of Finance of St. Petersburg, the state information system for information and analytical support of the activities of the executive bodies of state power in St. Petersburg and the automated system of the budget process of St. Petersburg.

As a conclusion, arguments are provided not to use the results of monitoring the financial management quality, conducted by the financial authorities of the Russian Federation regions, due to its inherent specificity and its special role in the system of minimizing budgetary risks. The observations and conclusions made can be useful for further studies of key performance indexes’ systems for government bodies.
The Relationship between Endotypes and Exacerbation Events in COPD
Patients
Authors: Juwita Putri Mega , Amin Muhammad , Rosyid Alfian Nur
Published: October 2023

Introduction:

Acute exacerbations of COPD are responsible for 60% of health costs, reduce
patients' quality of life, and accelerate disease progression. COPD endotypes are expected to
provide new insights about clinical phenotypic variability and therapeutic response between individuals
through certain biomarker approaches.

Objective:

Our study aims to identify the relationship between COPD endotypes and exacerbation
events.

Methods:

In this cross-sectional study design, participants with stable COPD (n=40) were recruited
from the outpatient clinic at Airlangga University Hospital in March-August 2022. Blood was
obtained for endotype's biomarker examination, such as α1-antitrypsin (AAT), IL-17A, neutrophil,
and eosinophil count. The relationship between COPD endotypes and exacerbation events was analyzed
using a non-parametric statistical test

Result:

The lower limit normal of AAT levels obtained was 12.85ng/ml; 47.5% of subjects have
low AAT levels. The average IL-17A levels and blood neutrophil counts were 0.478 ± 0.426
pg/ml and 5,916.95 ± 3,581.08 cells/µl, respectively. The average blood eosinophil count was
298.35 ± 280.44 cells/µl, 16 of 40 (40%) subjects with blood eosinophil count > 300 cells/µl. No
significant association was observed between AAT levels (p = 1.000), IL-17A levels (p = 0.944),
and blood eosinophil count (p = 0.739) with exacerbation events-only blood neutrophil count (p =
0.033) found to have a significant association with exacerbation events in COPD.

Conclusion:

AAT levels, IL-17A levels, and blood eosinophil count were not significantly related
to exacerbation events in COPD patients. In comparison, blood neutrophil count was the only one
associated considerably with exacerbation events. Further research about COPD endotypes is
needed to identify exacerbation susceptibility as a precision treatment strategy.
Sex and Gender Differences in Medical Education: The Impact on
Scientific Reports
Authors: Mattioli Anna Vittoria , Coppi Francesca , Bucciarelli Valentina , Nasi Milena , Pinti Marcello , Palumbo Carla , Gallina Sabina
Published: October 2023

This commentary explores the reasons why sex and gender differences must be
included in medical education and the impact on healthcare outcomes for patients. Understanding
sex and gender differences could be useful in making more accurate diagnoses and
to develop more effective treatment plans. Sex and gender medicine take into consideration
both the genetic basis and the effects of exposure to environmental and socio-economic factors.
The silent scream of nurses: a qualitative study
Authors: Kayserilioğlu Gülşah , Bulut Özlem Ülkü
Published: October 2023

Introduction. Nowadays, the importance of nursing science is increasing in the organization, execution, and development of health services. Nurses working in the health institutions encounter countless tragedies while performing healthcare services to patients and families where uninterrupted service is provided 7 days 24 hours. Biopsychosocial changes seen in individuals because of violence in the working environment are silent screams. It is necessary to share feelings and experiences to make the silent scream audible.

Aim. In this article, it is aimed to contribute to narrative studies, to draw attention to the violence experienced by nurses in the working environment and the insufficiency of the measures taken by examining the patient stories of two nurses with clinical experience.

Method. In the study, two nurses with a professional experience of five years or more were asked to write one of the most memorable anecdotes they have experienced in their professional life. The anecdotes were analyzed through the "Novel, Story, Epic, Tale, Diary, Memory, Mythology and Analogous Rating Scale".

Results. Three sub-problems are discussed in this research. Data related to each sub-problem were collected and analyzed. In these two narratives, it was determined that the patients behaved implausible in some situations and their problematic behavior was the dominant common feature. In the first narrative, the categories can be classified under "Behavior of the patients - solutions of the nurses" and in the second narrative under "Emotions of the patient - Emotions of the nurses". The primary point to be reached in both stories can be considered as follows: "The professional approach of healthcare professionals towards challenging patient behaviors they confront." The incidence of violence could be reduced if the nurses have adequate professional knowledge, experience, and skills and inform patients about the procedures.

Conclusion. In this study, it is emphasized that sufficient measures are not taken in violence against healthcare professionals in Turkey, that seriously affects employee health and negatively affects the functionality of health services in terms of quality.
Opiekuńcza i wspierająco – edukacyjna rola pielęgniarki wobec pacjenta pediatrycznego w przebiegu zakażenia układu moczowego - studium indywidualnego przypadku
Authors: Lazarowska Julita
Published: October 2023

Wstęp. Zakażenia układu moczowego są jedną z najczęstszych przyczyn pobytu dzieci w placówkach szpitalnych. Obecność bakterii w układzie moczowym często daje specyficzne objawy, jednak przebieg zakażenia za każdym razem może wyglądać inaczej, zwłaszcza że infekcja ta wykazuje dużą skłonność do nawrotów. Zgodnie z najnowszymi wytycznymi Polskiego Towarzystwa Nefrologii Dziecięcej należy podejrzewać zakażenie układu moczowego u każdego dziecka gorączkującego (od 24 do 48h) bez uchwytnej przyczyny, której mogą, ale nie muszą towarzyszyć inne objawy.

Cel. Celem niniejszej pracy jest rozpoznanie problemów pielęgnacyjnych pacjenta pediatrycznego z zakażeniem układu moczowego oraz dobór i wdrożenie prawidłowego modelu postępowania pielęgniarskiego.

Prezentacja przypadku. Pacjentka, lat 9 została przyjęta do szpitala z powodu gorączki 39,2°C, bólu w podbrzuszu, wymiotów i objawów dyzurycznych. Objawy utrzymywały się od ponad 24 godzin i nie ustępowały pomimo przyjmowanych leków przeciwgorączkowych i przeciwbólowych. Stwierdzono cechy odwodnienia wynikające z gorączki, występujących wymiotów i małej ilości przyjmowanych płynów.  Pacjentka zgłasza duży dyskomfort podczas oddawania moczu. Dziewczynka oraz rodzice mają bardzo niski poziom wiedzy z zakresu choroby.

Wnioski. W opiece nad dzieckiem z zakażeniem układu moczowego pielęgniarka ma do czynienia z wieloma poważnymi problemami pielęgnacyjnymi. Zakażenie układu moczowego powoduje szereg objawów, z których najważniejsze to: wysoka gorączka, objawy dyzuryczne z towarzyszącym bólem, zaburzenia gospodarki wodno-elektrolitowej spowodowane wymiotami, niepokój i lęk pacjentki oraz jej rodziców w związku z hospitalizacją. Rola pielęgniarki w procesie opiekuńczymi i wspierająco- edukacyjnym powinna opierać się na aktualnej wiedzy, dowodzie naukowym, ale również na podejściu do pacjenta pediatrycznego w sposób empatyczny, pełen zrozumienia, z umiejętnością prawidłowej komunikacji z rodzicami, a także poszanowaniem godności.
Gorączka u dzieci - charakterystyka zaburzenia
Authors: Jagieła Jolanta , Kochman Dorota
Published: October 2023

Wstęp. Wystąpienie gorączki u małego dziecka jest jednym z najczęściej występujących problemów zdrowotnych z jakimi spotykają się rodzice w codziennej opiece nad dzieckiem. Szczególnie niebezpieczna jest ona u małych dzieci do 5 roku życia, które z powodu charakterystycznej dla tego wieku niedojrzałości układu nerwowego, są najbardziej narażone na pojawienie się drgawek gorączkowych przy wysokiej i nieprawidłowo obniżanej gorączce.

Cel. Celem pracy było przedstawienie problematyki gorączki u dzieci.

Materiał i metody. Metoda zastosowana w pracy to analiza literatury.

Przegląd. Gorączka u dziecka jest stanem klinicznym, którego przyczyny zmieniają się w zależności od okresu rozwoju życia dziecka. U najmłodszych dzieci dominują czynniki infekcyjne układu oddechowego, pokarmowego, dróg moczowych i ośrodkowego układu nerwowego. Dzieci starsze gorączkują najczęściej z przyczyn tzw. nieinfekcyjnych, do których należą choroby immunologiczny, nowotwory, nieswoiste zapalenia jelit czy choroby tkanki łącznej.

Wnioski. Stany gorączkowe są bardzo częstym powodem hospitalizacji dzieci do 5 roku życia. W okresie przedszpitalnym rodzice w kontakcie z personelem pielęgniarskim wielokrotnie informują o braku wiedzy na temat niefarmakologicznych metod obniżenia gorączki, mają obawy o poprawne podanie leków przeciwgorączkowych. Edukacja w tym zakresie jest niezbędnym zadaniem, jeśli chodzi o personel medyczny.
The role of family support in self-control of individuals with hypertension in Sindangasih village, Cianjur regency
Authors: Arini Ayu Shinta , Sari Rahayu Eka , Eshadrianti Idris Fajriah
Published: October 2023

Introduction. One of the social support systems is obtained from the family, family members play a very important role in influencing or changing their own lifestyle towards efforts to improve health including self-care for people with hypertension.

Aim. This study identified the role of family support on self-control individuals with hypertension in Sindangasih Village, Kab. Cianjur.

Research Methods. The design of this study is correlation analytic with the cross-sectional. Sampling using purposive sampling with a total sample of 106 people. Data Primary obtained from questionnaires and observation results. The research was conducted in the village Sindangasih with a timeframe of November 2022 - May 2023.

Results. The results of the statistical test using quantitative correlation research with a significance level (a) s0.05, indicating that there is a correlation between the role of family emotional support and the self-care behavior of people with hypertension (p=0.000), there is a correlation between the role of family esteem support and the self-care behavior of people with hypertension (p=0.001), there is a correlation between the role of family information support and the self-care behavior of people with hypertension (p=0.001), there is a correlation between the role of family instrumental support and the self-care behavior of people with hypertension (p=0.000), there is a correlation between the role of family support and self-care behavior of hypertension sufferers (p=0.000) in Sindangasih Village, Kab. Cianjur.

Conclusion. Family support can be a strategy that can be used to manage hypertension and other diseases because it is included in both and positive impact on patient self-care habits.