bluuebunny/crossref_metadata_2025 huggingface dataset:
PERAMALAN PERMINTAAN PRODUK TIRAI MENGGUNAKAN METODE MOVING AVERAGE DAN EXPONENTIAL SMOOTHING (Studi Kasus pada Meubel Sarira Waitatiri Maluku Tengah)
Authors:   Politeknik Negeri Ambon Indonesia, Fredriksz Grace
Published: January 2023

This study aims to determine the most effective method of demand forecasting for curtain products at the Sarira furniture company in Waitatiri, Central Maluku, so that the production of the goods is not too many. The demand forecasting method used in this research is the Moving Average method and the Exponential Smoothing method. The methods analyzed are the 3-month and 5-month Moving Average methods, as well as Exponential Smoothing with values of 0.1, 0.5, and 0.9. The results of each method are compared based on the level of error. The calculation of how far a prediction is made is called the forecast error rate. This calculation is carried out for curtain products, and MSE is used to represent the error rate. The demand for curtains with a Mean Squared Error (MSE) is: moving average 3-month = 314.89. 5-month moving average = 222.29. Exponential Smoothing 0.1 = 256.82. Exponential Smoothing 0.5 = 290.09. Exponential Smoothing 0.9 = 393.09. So, the most efficient method for forecasting curtain products is the 5-month moving average method because the error rate or MSE of 222.29 is very small.
KEPUTUSAN PEMBELIAN SMARTPHONE XIAOMI REDMI NOTE 10 5G DI ERA PANDEMI COVID -19 (Studi pada Mahasiswa Universitas Tidar)
Authors:   Universitas Tidar Indonesia, Yulianingsih Tri , Verawati Dian Marlina ,   Universitas Tidar Indonesia, Novitaningtyas Ivo ,   Universitas Tidar Indonesia
Published: January 2023

This study aims to find out how the influence of product features, consumer preferences, and prices on purchasing decisions for the Xiaomi Redmi Note 10 5G smartphone product in the era of the covid-19 pandemic on Tidar University students. The method used in this study is Experimental pretest posttest with the number of samples in this study as many as 30 respondents. The use of the pretest posttest experimental method is by giving treatment to the experimental group, namely in the first experiment the group was not treated while the second experimental group was given treatment and then the results of the two were compared. The data used in this study used primary and secondary data where primary data was obtained using questionnaires and interviews, while secondary data was obtained through previous research. The data analysis technique in this research is multiple linear regression analysis. The results in the first experiment that product features and price variables partially have no effect on purchasing decisions, but preference variables have a positive and significant effect on purchasing decisions. The results of the second experiment show that the product features, consumer preferences and price variables partially have a positive and significant effect.
Multicriteria analysis of the effectiveness of high-speed rails construction projects: case study of the Czech Republic
Authors:   Masaryk University Brno, VITURKA Milan , PAŘIL Vilém ,   Masaryk University Brno, CHMELÍK Jakub ,   Czech Railways
Published: January 2023

This article seeks to evaluate the effectiveness of planned public construction projects of high-speed rails in the Czech Republic through the application of multicriteria analysis. In line with the nature of the projects, the developed original evaluation methodology places the main emphasis on the potential production of positive effects and on minimizing adverse effects. It includes criteria for integration, relevance, usefulness, stimulation, and sustainability. In this context, article provides synthesized information on the factual focus and geographical and practical context of application of the criteria used, and further on the results of the comparative evaluation of the four main planned high-speed routes. The acquired knowledge is subsequently discussed from the point of view of the most important stakeholders, interpreted through relevant scenarios, i.e. investor, business, and civic scenarios. URL: https://www.gcass.science.upjs.sk/
Factors affecting migration destination choices of international migrant workers in Slovakia
Authors:   Economics University in Bratislava, BEŇOVÁ Zuzana , BROCKOVÁ Katarína ,   Economics University in Bratislava
Published: January 2023

The main goal of this paper is to determine the main economic factors that influence the self-selection process of migrant workers when settling in Slovakia. Considering the growing number of migrant workers in Slovakia, it is necessary to determine which factors influence them most when choosing a final destination within the country. Paper deals with the allocation of migrant workers in Slovakia focusing on the mutual relationship between the total number of migrant workers and the average wage, and the number of vacancies in 2010 and 2020 in individual districts. The paper also analyses the domestic labour market with emphasis on internal and foreign labour migration. The study is based on migration and self-selection process theories. In the paper, we work with data from public institutions in Slovakia, especially the Ministry of Labour, Social Affairs and Family, the National Bank of Slovakia and the Statistical Office. To achieve the goal, Spearman's coefficient is used and its significance and linear regression are tested. The results show that the correlation between the number of migrant workers in individual districts and the number of vacancies was stronger than the correlation between the number of migrant workers and the amount of average wage in both monitored years 2010 and 2020. URL: https://www.gcass.science.upjs.sk/
Methods of modeling and mapping of the soil bulk density: a case study from Chernivtsi region, Ukraine
Authors:   Pavol Jozef Šafárik University in Košice, CHERLINKA Vasyl , DMYTRUK Yuriy ,   Podilskyi State University, CHERLINKA Liubov ,   Yuriy Fedkovych Chernivtsi National University, GUNCHAK Mykhailo ,   Soil Protection State Institute of Ukraine, SOBKO Volodymyr ,   Soil Protection State Institute of Ukraine
Published: January 2023

Soil monitoring programs in many countries often do not measure such an indicator as soil bulk density. At the same time, modern problems of assessing the condition of the soil cover require its use in soil management of agricultural landscapes. We see the solution to this problem in geospatial modeling. We have developed a technique for simulating soil bulk density, the algorithm of which consists of five stages: the creation of model maps of agro-industrial soil groups, modeling of a clay content map, construction of a map of humus content, selection of empirical dependences of soil bulk density on humus and clay content with evaluation reliability of these dependencies and their implementation in GRASS GIS and, finally, cartographic modeling of the spatial continuous distribution of soil bulk density. At the same time, parameters for improving the quality of methods modeling and mapping the soil bulk density were established. First of all, this is an increase in the sampling dataset of density, humus, and clay content to improve the reliability of the selected regression formula. It is also an improvement in the quality of spatial modeling of the humus content using geostatistical methods or modeling. To improve the clay content map, it is necessary to increase the resolution of DEM and predictors, to choose more accurate sources of DEM and prediction algorithms. The application of the presented methodology is shown in a part of Chernivtsi region, Ukraine, with the possibility of use on the scale of the entire country. URL: https://www.gcass.science.upjs.sk/
Epiphytic lichen diversity in the urban area of Košice (E Slovakia) with some notes on its air quality
Authors:   Pavol Jozef Šafárik University in Košice, Marcinčinová Margaréta , Tuptová Viktória ,   Pavol Jozef Šafárik University in Košice
Published: January 2023

Lichen diversity in the City of Košice was studied investigating lichen diversity on 160 trees distributed over 32 sites. Its relationship to pollution sources (steel plant, thermal power station) were determined by calculating the IAP (Index of Atmospheric Purity). A total of 60 lichen species was found, 30 of which are endangered. The rare species Parmelina quercina is reported for the first time. The lichen diversity in the City of Košice is decreasing as we move closer to the sources of pollution and also in the southern part of the city. An intermediate level of diversity was identified in residential areas, parks and forest parks. The highest diversity was found in the recreational area at the forest edge, Bankov. URL: https://www.upjs.sk/pracoviska/botanicka-zahrada/odborne-aktivity/contents-abstracts/
Human-nature relationships in the collections of the National Archaeological Museum of Naples: a botanical perspective
Authors:   University of Naples Federico II, Motti Riccardo , Ricciardi Massimo ,   University of Naples Federico II, Giulierini Paolo ,   National Archaeological Museum of Naples
Published: January 2023

The portrayal of plants depicted in works of art in antiquity can provide insights into human–nature relationships. We have identified the botanical species sculpted on marble and stone and depicted on wall paintings, vases, mosaics, and furnishings in the National Archaeological Museum of Naples, which houses the greatest collection of Greco-Roman antiquities in the world. In detail, the main objectives of the present study were to analyse and discuss the symbolic role of some plants more strongly linked to a deity or involved in other aspects of Greco-Roman life and customs. The attention was particularly devoted to their symbolic role in mythology, their use in medical and ritual practices, their artistic meaning in domestic representations and their representation in Nilotic scenes. URL: https://www.upjs.sk/pracoviska/botanicka-zahrada/odborne-aktivity/contents-abstracts/
Bryophyte flora of the Košice Zoo (E Slovakia)
Authors:   Technical University in Zvolen, Širka Pavel , Marcinčinová Margaréta ,   Pavol Jozef Šafárik University in Košice, Dudáš Matej ,   Pavol Jozef Šafárik University in Košice, Kubešová Svatava ,   Moravian Museum, Brno
Published: January 2023

In this paper we studied bryophyte flora of the Košice Zoo and analyzed morphological, life history and ecological traits of the recorded taxa. A total of 129 bryophyte taxa (10 liverworts and 119 mosses) were identified on nine substrate types. One species (Physcomitrium eurystomum) potentially belongs to vulnerable species in Slovakia and all of Europe (its identification needs confirmation) and one species (Schistidium dupretii) is new to Slovakia. Out of 14 different life forms, the recorded species most frequently form turfs and rough mats, while colonists and perennials predominate among seven displayed life strategies. On average, species found indicate rather well-lit, drier but at the same time colder situations. Most taxa prefer acidic soils but a significant portion are also found on basic substrate. Roughly half of the identified species are bound to forests and roughly half to open land. Almost half of the species found show stronger affinity towards natural ecosystems but a smaller portion are also indicative of ecosystems with a very strong human impact. Substrate frequency indices show that most taxa usually grow on natural rock, soil and gravel or sand but a significant portion are also bound to man-made rock, and both living and dead wood. Such noticeable functional and ecological bryophyte diversity is attributed to a complex geology and diverse landscape of the zoo area which has the prerequisite of being a local hotspot of diversity of other organism groups as well. The Košice Zoo has a major potential in educating visitors about the connection between animals, plants and their habitat and in their active conservation. URL: https://www.upjs.sk/pracoviska/botanicka-zahrada/odborne-aktivity/contents-abstracts/
New floristic records from Central Europe 10 (reports 134-148)
Authors:   Pavol Jozef Šafárik University in Košice, Dudáš Matej , Ďurišová Ľuba ,   Slovak University of Agriculture Nitra, Eliáš Jr. Pavol ,   Slovak University of Agriculture Nitra, Eliášová Mariana ,   Slovak University of Agriculture Nitra, Kobiv Yuriy ,   National Academy of Sciences of Ukraine, Kšiňan Samuel ,   Slovak University of Agriculture Nitra, Malovcová-Staníková Miroslava ,   Homeland museum Hlohovec, Pliszko Artur ,   Jagiellonian University, Kraków, Taraška Vojtěch ,   Moravian Museum Brno
Published: January 2023

The presented 10th part of the series includes fifteen new chorological records, one from Czechia, two from Hungary, three from Poland, five from Slovakia and four from the Ukrainian Carpathians. In Czech Silesia, Arum maculatum, considerably remote from the species continuous distribution area, was found. In Hungary, spreading of Geranium sibiricum and Limonium gmelinii subsp. hungaricum was recorded. In Poland, two alien Erigeron sumatrensis and Lepidium didymum were found as well as the native species Typha shuttleworthii, which is considered vulnerable. In Slovakia, new localities of Scorzonera humilis, Stellaria ruderalis, Taraxacum serotinum and Typha shuttleworthii were found as well as alien Portulaca grandiflora. New records of Centaurea kotschyana, Euphrasia salisburgensis, Galium album subsp. suberectum and Salix retusa were reported in the Ukrainian Carpathians. URL: https://www.upjs.sk/pracoviska/botanicka-zahrada/odborne-aktivity/contents-abstracts/
Dydrogesterone: Shining New Light on Life
Authors: Brown Helen
Published: January 2023

This symposium took place during the 2018 Annual Meeting of the European Society of Human Reproduction and Embryology (ESHRE). It centred on the role of progestogens in the treatment of recurrent pregnancy loss (RPL) and in luteal support during assisted reproductive technology (ART), with consideration also given to the relevance of maternal adaptation in human pregnancy being under the control of progesterone and progestins. Focussing on the potential role of dydrogesterone (DYD) in the treatment of RPL, the speakers discussed the role of progestogens and how they might fit into the ESHRE guidelines for recurrent miscarriage, as the effect of this treatment approach continues to be debated. In particular, the presenters discussed whether DYD could address the current issues associated with this class of drugs; they presented evidence from the recent LOTUS I study comparing DYD with micronised vaginal progesterone (MVP) and whether the effects may be linked to supporting maternal immune adaptation for successful blastocyst implantation and the progression of pregnancy, the latter being assessed by the amount of CD4+ T regulatory cells in peripheral blood and the levels of local immune cell subsets and immunosuppressive molecules evaluated in endometrial biopsies. There remains a need for further trials to evaluate the benefits of administering progestogens from the luteal phase of pregnancy.
Parental Protein Malnutrition Programmes of Offspring Growth and Vasculature to Increase Risk of Cardiovascular, Pancreatic, and Metabolic Disease. Lessons Learned from Animal Studies
Authors: Ruiz-Diaz Maria Dolores , Partridge Hannah , Davidson Francesca , Mongan Nigel P. , Gardner David S. , Rutland Catrin Sian
Published: January 2023

It is well known that consumption of a balanced diet throughout adulthood is key toward maintenance of optimal body weight and cardiovascular health. Research using animal models can provide insights into the programming of short and long-term health by parental diet and potential mechanisms by which, for example, protein intake may influence fetal development, adolescent health, and adult morbidity/ mortality. Malnutrition, whether consumption of too many or too few individual nutrients or energy, is detrimental to health. For example, in Westernised societies, one of the principal factors contributing towards the global epidemic of obesity is over-consumption of calories, relative to the expenditure of calories through physical activity. A large body of evidence now suggests that many chronic diseases of adulthood, such as obesity and diabetes, are linked to the nutritional environment experienced by the fetus in utero. Maternal consumption of a poor-quality, nutritionally unbalanced diet can programme offspring to become obese, develop high blood pressure and diabetes, and to experience premature morbidity and mortality. More recently, paternal diet has also been shown to influence offspring health through effects carried via the sperm that affect post-fertilisation development. Mechanisms underpinning such developmental programming effects remain elusive, although early development of the microvasculature in the heart and pancreas, particularly after exposure of the mother (or father) to a protein restricted diet, has been proposed as one mechanism linking early diet to perturbed adult function. In this brief review, we explore the longer-term consequences of maternal and paternal protein intakes on the progeny. Using evidence from relevant animal models, we illustrate how protein malnutrition may ‘programme’ lifelong health and disease outcomes, especially in relation to pancreatic function and insulin resistance, and cardiac abnormalities.
Speed, Agility and Power Potential of Young Basketball Players
Authors: Čaušević Denis , Mašić Semir , Doder Ivor , Matulaitis Kęstutis , Spicer Seth
Published: January 2023

Background. As basketball constantly evolves, physical performance becomes more and more important. Physical fitness assessments are the most reliable way to find out at what level a basketball player is prepared to perform. Therefore, the main aim of this research was to determine if the speed, agility and power of under-16-year-old (U16) basketball players is related to their playing positions.
Methods. The study included (n = 40) young basketball (aged 14.99 ± 0.84 years) players. The variables included height, body mass, body mass index (BMI), fat-free mass (FFM), the percentage of body fat (BF%), the counter movement jump (CMJ), counter movement jump with free arms (CMJ free arms), squat jump (SJ), 5m, 10m, 15m and 20m sprints, T-test, Illinois test and 505 test.
Results. The results showed that centers are taller and heavier than other positions, while the speed, agility and power of forwards are greater than other positions.
Conclusions. At the youth basketball level there are differences in anthropometric and physical fitness testing results between positions. This supports the fact that athletes may be more likely to be selected for a given position based on how their anthropometric and athletic abilities pair with the demands of a given position.
Keywords: body composition; physical testing; playing position; performance.
PKM Sosialisasi Pengelolaan Sampah dengan Alat Pintar Mikrokontroler Sistem IOT dan Kontrol Telegram di SMK Zainul Hasan Genggong
Authors: Hudawi Ahmad , As'adi Muhammad , Thaariq Muhammad Haikal Ath , Amir Muhammad , Ridho Muhammad Ali
Published: January 2023

Meningkatnya kebutuhan masyarakat terhadap berbagai macam produk, serta meningkatnya UMKM yang mendukung pertumbuhan ekonomi daerah pasti menyebabkan meningkatnya jumlah sampah yang drastis, dengan meningkatnya jumlah sampah yang dihasilkan, pengelolaan sampah yang kurang baik berdampak pada permasalahan lingkungan. Sampah adalah sebuah ancaman bagi lingkungan sekitar kita, akibat pembuangan sampah sembarangan tempat, disamping merusak lingkungan juga merusak ekosistem lingkungan, dan menyebabkan pencemaran terhadap air, sampah-sampah plastik yang tidak bisa diuraikan oleh tanah akan mengakibatkan menumpuknya sampah dan limbah, kesadaran akan bahaya membuang sampah sembarangan sangat kurang. Dalam permasalahan tersebut maka perlu adanya tempat sampah pintar berbasis Mikrokontroler Arduino yang meliputi Sensor Ultrasonic HC-SR04 sebagai pendeteksi jarak dan pendeteksi volume tempat sampah, Penggunaan sensor otomatis dengan remot kontrol yang bertujuan memberikan pemahaman peran alat pintar ini adalah solusi yang maksimal rancang bangun tempat sampah secara otomatis menggunakan sensor ultrasonik adalah sensor ultrasonik mendeteksi seseorang di depan tempat sampah kurang dari 70 cm, selanjutnya yaitu data diproses oleh arduino uno untuk memutar motor servo dalam membuka tutup tempat sampah. Hasill bahwa sosialisasi  memberikan pengaruh terhadap nilai pre test dan post test. Hal ini dibuktikan dengan nilai Sig. < 0,05 yaitu sebesar 0,000. Dapat disimpulkan sosialisasi tentang pengolahan sampah dengan alat pintar dapat merubah perilaku siswa SMK Zainul Hasan Genggong terhadap kesadaran kebersihan lingkungan
PKM Sosialisasi Pengenalan Bahasa Inggris Menyenangkan dengan Media Wayang di Yayasan Al-Ikhlas
Authors: Adi Pranata Mohammad Sofyan , Afifah Dzurratul Afra
Published: January 2023

Generasi muda Indonesia saat ini harus mengetahui seni pertunjukkan wayang agar kesenian yang sudah diakui oleh dunia tidak hilang dimakan kemajuan zaman. Langkah tersebut bisa dimulai dari usia sekolah dengan menampilkan pertunjukkan- pertunjukkan wayang Indonesia. Wayang tidak hanya dapat dipelajari melalui mata pelajaran kesenian daerah saja, tetapi juga dapat dijadikan sebagai salah satu media pembejaran utamanya pembelajaran bahasa inggris. Tujuan dari diselenggarakannya pengabdian ini adalah untuk membuat santri senang belajar bahasa inggris dengan konsep melestarikan pewayangan sebagai media yang menyenangkan. Metode yang digunakan dalam “Sosialisasi Pengenalan Bahasa Inggris menyenangkan dengan media wayang” menggunakan peragaan secara langsung. Dengan program tersebut, santri Yayasan Al-Ikhlas menunjukkan rasa antusias dan semangat belajar Bahasa Inggris dengan media wayang
PKM Pelatihan dan Pendampingan Penggunaan Aplikasi Reservasi Jadwal Kunjungan Santri Berbasis Android bagi Wali Santri dan Pengurus Pondok Pesantren Nurul Jadid Probolinggo
Authors: Rizal Fathur , Dumairi Dumairi , Aditya Nugroho Dwi Setyo , Yunianto Febrian As Shella , Prabowo Fendi , Hasan Hafidul
Published: January 2023

Pondok Pesantren Nurul Jadid pada tahun 2020 (saat pandemi) telah mengembangkan sistem kiriman santri yang dinamakan dengan E-Bekal. Sistem tersebut dibangun untuk mempermudah wali santri dalam melakukan pengiriman bekal santri dalam bentuk cashless dan mempermudah santri dalam melakukan transaksi di wilayah pesantren. Namun meskipun terdapat sistem tersebut masih terdapat wali santri yang ingin mengujungi putranya meskipun dalam sebulan sekali kunjungan. Maka dari itu, Pesantren telah mengembangkan sistem reservasi kunjungan santri yang dapat digunakan oleh wali santri namun sistem atau aplikasi tersebut masih belum disosialisasikan kepada wali santri serta cara mengoperasikann sistem tersebut. Oleh sebab itu pengabdian ini mencoba untuk memberikan pemahaman dan pendampingan penggunaan aplikasi reservasi jadwal kunjungan santri kepada wali santri dan pengurus pesantren nurul jadid. Tahapan pelaksanaan pelatihan dan pendampingan penggunaan aplikasi reservasi jadwal kunjungan santri dibagi menjadi 3 tahapan yakni Persiapan Kegiatan, Pelaksanaan Kegiatan dan Evaluasi Kegiatan. Hasil pelaksanaan pelatihan dan pendampingan penggunaan aplikasi sambang santri dapat mengatasi permasalahan yang dialami oleh mahrom yakni meningkatkan pemahaman serta keterampilan pengurus mahrom dan wali santri dalam penggunaan aplikasi sambang santri
PKM Pendampingan dan Pelatihan JIBAS untuk Meningkatkan Digitalisasi Akademik Madrasah Aliyah Nurul Jadid Probolinggo
Authors: Sukron Moh. , Dzulqarnain Maulana Afnani , Huda Miftahul , Jannah Miftahul , Syahroni Moh. Arif , Ishak Moh. Riski Maulana , Andi Moh. Syaiful , Dhofir Moh. Affandi Zamahsyari
Published: January 2023

MA Nurul Jadid merupakan sekolah tingkat SLTA yang berada dibawah naungan pondok pesantren Nurul Jadid Paiton Probolinggo. Lembaga pendidikan ini memiliki sekitar 1.200 siswa dan 87 guru serta 60 staf karyawan. Dalam penggunaan dan penyimpanan data tentu sistem terkomputerisasi dirasa tepat dalam pengolahan data. JIBAS merupakan layanan akademik yang diharapkan dapat membantu proses pengolahan data di lingkukangan akademik MANJ Paiton Probolinggo. Pemanfaatan layanan JIBAS ditekankan pada pengolahan data siswa, karyawan, guru serta absensi. Namun pelaksaanannya masih terkendala cara menggunakan layanan ini secara maksimal. Penambahan fitur baru serta minimnya pelatihan dan pendampingan cara penggunaan JIBAS menjadi faktor utamanya. Sehingga sering kali proses rekap absensi setiap bulanya terlambat dan menghambat rekapitulasi karyawan MANJ. Program pelatihan ini bertujuan untuk memenuhi kebutuhan pengetahuan dan keterampilan guru dan karyawan MANJ dalam bidang layanan JIBAS sehingga ke depannya guru dan karyawan MANJ dapat memannfaatkan layanan JIBAS sesuai dengan harapan dan kebutuhan pihak MANJ yang lebih baik lagi. Kegiatan dimulai dengan pengenalan dan pengarahan mengenai definisi dan penggunaan layana JIBAS dalam bidang pendataan dan proses absensi kemudian praktik langsung menggunakan aplikasi JIBAS yang telah di publik oleh guru dan kayawan MANJ. Di bagian akhir dilakukan evaluasi untuk mengukur tingkat pemahaman dan kemudahan dalam implementasi layanan JIBAS.
Comparative Anatomy of the Caudal Skeleton of Cyprinid Fishes
Authors: Rupesh N. Raut , Sanjay S. Kharat
Published: January 2023

With at least 3006 species, the family Cyprinidae is the most varied group of freshwater fishes in the entire globe. The development of a more thorough understanding of the evolution within any taxon can be assisted using osteological data. The current study is the first attempt to investigate the osteological relationships among members of the Subfamily- Labeoninae- tribe Garrini (Garra mullya), Subfamily Smiliogastrinae (Puntius mahecola, Puntius sahyadriensis, Rohtee ogilbii and Systomus sarana), Family Danionidae (Barilius barna, Barilius bendelisis and Salmophasia balookee), Family- Danionidae Subfamily Danioninae (Devariao aequipinatus) and Family DanionidaeSubfamily Rasborinae (Rasbora daniconius and Rasbora labiosa). Members of the aforementioned species were procured from local markets or collected from the wild from Lonavala, Karjat, Patan, Pune, Bhor, and Malvan, and they were then preserved in either absolute alcohol or 4% buffered formalin. These preserved specimens were identified and used for cleaning and staining with slight modifications to the Taylor and Van Dyke (1985) methodology. Under an Olympus SZX Stereo microscope, these cleaned and stained specimens were examined. Photos were taken, and pictures or drawings were created for further research. Variations in the caudal fin's components were studied.
Hepatotoxic and Nephrotoxic Potential of an Anticancer Drug Paclitaxel after Prolong Exposure in Adult Female Rats
Authors: Deepika Pathak , K.P. Singh
Published: January 2023

Paclitaxel (PTX) is a microtubule inhibitor commonly used as a potent chemotherapeutic agent for treatment of a variety of cancers including breast cancer. PTX is causing several serious side effects during and after chemotherapy related to metabolic and renal dysfunctions. Clinical and non-clinical studies on PTX exposure and histopathological changes in liver and kidney are limited; therefore present study was designed to evaluate hepatotoxicity and nephrotoxicity of PTX in adult female rats. In this regimen, equivalent therapeutic doses of PTX (1.6 and 3.2 mg/kg BW) were intravenously administered weekly for six weeks. After six weeks of exposure, liver and kidney of PTX exposed and control rats were extirpated, fixed in 10% neutral buffered formalin for paraffin sectioning. As per protocol, sections of liver and kidney were cut at 8 µm and finally stained with Haematoxylin and Eosin. Our results demonstrated that intermittent exposure to PTX for six weeks (once per week) induced substantive histopathological changes in liver (hepatocyte derangement, blood clotting, and CV dilatation) and kidney (glomerular atrophy, vascular congestion, dilation of distal tubules) of female rats.
Prevalence and Distribution of Hard Ticks (Acari: Ixodidae) in Domestic Animals from Solapur District, Maharashtra, India
Authors: Nikhil D. Adsule , Usha V Gavhane
Published: January 2023

In the present study, species diversity, prevalence and distribution of hard ticks was conducted along six substations; Barshi city, Gadegaon, Khandavi, Soundare, Ridhore and Wadshinge from Barshi and Madha Taluka of Solapur District, Maharashtra, India. Hard ticks were collected from domestic animals (canines, cattle and cats) monthly from January 2021 to December 2021. A total of 450 domestic animals were inspected, of which 233 animals comprising 103 canine, 108 cattle and 22 cats were infested with ticks. 2 species of hard ticks (Rhipicephalus sanguineus and Rhipicephalus microplus) were recorded from the study area. Recorded ticks revealed higher density and a serious infestation in studied domestic animals. In dogs, maximum density of ticks was recorded in and around ear and the neck, compared to appendages, abdomen, back and perianal region. While in cattle, abundance of ticks was found around the neck region (crest and dewlap), ear, and from the tail, head to the udder region. Cats revealed higher density of tick infestation to the ear only. This could be attributed to the abiotic factors like hot and arid climate of the study area for which the ticks show highest adaptation. Regular monitoring of the health, vaccination against bacterial and viral pathogens and to maintain health and hygiene of the domestic animals is recommended. Plant-based acaricidal compounds should be used for prevention and control of hard ticks. Study suggests practice of integrated approaches to manage the hard ticks in a sustainable manner.
Biological Evaluation of Cissus vitiginea Leaves Ethanol Extract with Anticancer Activities against MCF-7 and Vero Cell Lines
Authors: Begum V.S. Munasira , Tariq N.P.M. Mohamed , Hemapriya J.  , Shariq K. Muhammed , M.A. Farook
Published: January 2023

The present study investigated the phytoconstituents and anticancer potential followed by apoptotic studies of Cissus vitiginea leaves ethanol extracts on MCF-7 and Vero cells. Qualitative phytochemical analysis revealed the presence of carbohydrate, saponins, flavonoids, alkaloids, anthocyanin and betacyanin, quinones, glycosides, cardiac glycosides, terpenoids, triterpenoids, phenols, coumarins, acids, protein and steroids. On the other hand, tannins were absent in the ethanol extract. A dose-dependent anti-proliferative assay revealed that the 50% cell viability was observed at the concentration of 125 μg/ml with the ethanol extract. The maximum cell growth inhibition was observed at the concentration 1000 μg/ml (24.64 %). From the obtained data the ethanol extract were able to reduce the viability of MCF-7 cell line in direct dose dependent manner and thereafter, ethanol leaf extract was taken for further studies to assess it biocompatibility with Vero cells. Treatment of Vero cells with 24 h at different concentration of ethanol extract did not cause any changes in the Vero cells. From the results, it is clear that ethanol extract is biocompatible and can be used as a drug for treating various diseases including cancer
Osteological Features of Pelvic Girdle and Pelvic Fin in Cyprinid Fishes from Northern Western Ghats, India
Authors: Rupesh N. Raut , Sanjay S. Kharat
Published: January 2023

Osteology of pelvic girdle was studied in fishes of family Cyprinidae from Northern Western Ghats, India. Osteology from members of Subfamily- Labeoninae- tribe Garrini, Subfamily Smiliogastrinae, Family Danionidae, Family- Danionidae- Subfamily Danioninae and Family Danionidae- Subfamily Rasborinae was studied. Cleared and stained specimens were observed for variations in pelvic girdle and pelvic fins.
Detection of Herbicide Clomazone in Freshwater Teleost by Using HPLC Method
Authors: Kalpana Singh , Vandana Garg
Published: January 2023

Clomazone is widely used in cotton, soybean, tobacco and rice fields to control broadleaf weeds. The present study shows the accumulation of the herbicide clomazone in the tissues of the non-target organism, i.e. the fish Channa punctatus. After determining the LC50 of clomazone, different dosages for treating the fish with the herbicide were calculated. The fish were treated with three different concentrations, i.e. treated with high (0.5 ppm), mild (0.25 ppm) and low (0.08 ppm) doses of the herbicide. The fish were exposed to the three concentrations for 28 days and were sacrificed after 7, 14, 21 and 28 days. The herbicide clomazone was detected and quantified in gills, kidneys and liver extracted from fish by HPLC using the mobile phase (methanol:water) at a flow rate of 1 ml/min measured at 220 nm. This study gave an RSD of less than 1%, reflecting the accuracy of the method. The standard curve was linear in the range of 0.1 to 0.006 ppm. The detection and determination limits were 0.004 and 0.015 ppm, respectively. The study showed that gill accumulation of clomazone occurs after each fixed interval and at each dose. In contrast, kidney and liver only showed dose independent accumulation after prolonged exposure.
Computational Screening Approaches for Drug Discovery and Vaccine from Plant Derived Products Against Mosquito-Borne Diseases
Authors: Priyadarshini J. Flora , Babu M.  , Ashok K.
Published: January 2023

In order to deal correctly with difficulties, modern technology like computer tools and experimental techniques must be used quickly and efficiently. Ligand-binding sites are frequently the beginning point for protein annotation and drug design structures. In recent decades, several computer approaches have been developed for the prediction of binding sites. Knowledge of the 3D structures of protein has been known for long, but new advancements have altered the possibilities drastically in genome sequencing, robotics and bioinformatics. These high-performance structural determination methods can offer strong screening approaches in recent days.
Aquatic Toxicity Due to Heavy Metal Contamination in River Cauvery: Tiruchirappalli Surroundings, Tamil Nadu, India
Authors: Arulnangai R.  , Mohamed M. Sihabudeen , G. Muralitharan
Published: January 2023

The importance of water in our everyday lives cannot be overstated. Many heavy metals are present in natural water, but only at very low concentrations. Certain metals are essential to both human and animal health, but too much of these may be dangerous. The objective of this study was to ascertain whether or not the Cauvery River water in and around Trichy, Tamil Nadu, is fit for human consumption and other domestic applications. Ten samples of Cauvery River water were collected at different points in and around the Tiruchirappalli area. For this study, we used an atomic absorption spectrometer to determine the levels of Cu, Zn, Fe, Pb, and Mn. The studies were conducted at Tiruchirappalli, Tamil Nadu, on the Cauvery River after the monsoons had passed (2021). Copper and lead concentrations were found to be much over the legal limit (WHO, 2011). Heavy metal contamination of river water is an urgent environmental issue that needs fixing. Sewage from a wide range of commercial and noncommercial establishments must first undergo treatment before being discharged into the river. Awareness has to be promoted among those who work in industries, those who clean up after those companies, those who work for municipalities, and those who live in and around the areas being studied.
A Graphical Analysis of Mosquito Infection Model with Host and Vector Population
Authors: Lakshmi V.S.V. Naga Soundarya , Sabarmathi A.
Published: January 2023

A mosquito infection model was formulated consisting of SIR (Susceptible-Infectious-Recovered) with exposed and carrier class for humans as host and SI (Susceptible-Infectious) with exposed class for mosquitoes as vector. Numerical simulations were carried out for the diseases Malaria, Dengue and Chikungunya. The graphs on susceptible, exposed, carrier, infectious and recovered were given for the different values of parameters involved in the model. The comparative graphical study was done on the state variables.
From Actuarial to Behavioural Valuation. The impact of telematics on motor insurance
Authors: Cevolini Alberto , Esposito Elena
Published: January 2023

Algorithmic predictions are used in insurance to assess the risk exposure of potential customers. This article examines the impact of digital tools on the field of motor insurance, where telematics devices produce data about policyholders’ driving styles. The individual’s resulting behavioural score is combined with their actuarial score to determine the price of the policy or additional incentives. Current experimentation is moving in the direction of proactivity: instead of waiting for a claim to arise, insurance companies engage in coaching and other interventions to mitigate risk. The article explores the potential consequences of these practices on the social function of insurance, which makes risks bearable by socialising them over a pool of insured individuals. The introduction of behavioural variables and the corresponding idea of fairness could instead isolate individuals in their exposure to risk and affect their attitude towards future initiatives.
What is Digital Valuation Made of? The integration of valuation poles on a reservation platform and its effects on the hotel industry in Switzerland
Authors: Balsiger Philip , Jammet Thomas
Published: January 2023

Digital platforms act as new powerful intermediaries challenging existing market orders in many sectors. Algorithmically producing ratings and rankings often built from online consumer reviews, platforms are important players in the digitizing of valuation. This article asks how these new platform-generated valuations relate to other forms of valuation. It presents a qualitative case study of valuation in the hotel sector in Switzerland, drawing on interviews with professionals and a description of valuation categories on the Booking.com website. Going beyond the description of the opposition between online consumer reviews and traditional judgment devices, the analysis shows that valuation on the platform is based upon a permissive hierarchical integration of a plurality of valuation poles, with algorithmic valuation at its center. This destabilizes the evaluative landscape with regard to three issues: lack of transparency of the algorithmic ranking; weakening and even undermining of formulaic valuation; and the issue of singularization of the online offer.
Suture tape augmentation, a novel application of synthetic materials in anterior cruciate ligament reconstruction: A systematic review
Authors: Zheng Tong , Cao Yanwei , Song Guanyang , Li Yue , Zhang Zhijun , Feng Zheng , Zhang Hui
Published: January 2023

Objective: Suture tape (ST) is a common synthetic material in the repairing surgery of soft tissue. Recently, ST augmentation (STA) technique has been described as a novel way to improve the mechanical property of grafts in the anterior cruciate ligament (ACL) reconstruction (ACLR). However, the clinical outcomes of ACLR using ST-augmented grafts have not been clarified. This systematic review aimed to summarize the specific technique of STA and evaluate the clinical outcomes after ACLR with STA.

Methods: A electronic search of PubMed and Embase databases with a manual search of Google Scholar was performed to identify studies that reported the clinical outcomes of ACLR with STA. Each included study was abstracted regarding the study features, patient data, surgical information, and outcome measures.

Results: Nine studies were included, representing 314 knees in 314 patients undergoing ACLR with STA. Technically, ST was fixed independently from grafts in six studies and along with grafts in two studies. Most studies applied an equal or slightly less tension on ST than ACL graft. Clinically, significant improvements were found in the Lysholm, IKDC, and KOOS scores after a mean follow-up of 16.7 months. Physical examinations of 220 patients showed significant restoration of knee stability at the final follow-up. 59 of 80 (73.8%) patients returned to preinjury sports level at a minimum 2 year follow-up. Six of 266 (2.3%) patients had a graft failure during the first 2 years postoperatively. The use of ST was significantly associated with better Tegner scores and a trend toward significantly higher rates of return to sport compared to standard ACLR. No significant difference was found in most subjective scores, knee laxity, and graft failures between ACLR with or without STA.

Conclusion: ACLR with STA achieved overall favorable clinical outcomes. Patients using ST-augmented grafts were seemingly associated with better sports performance compared to standard ACLR. But ACLR with STA was not superior to ACLR alone in most functional scores, knee stability measures, and graft failure rates. A tension equal to or slightly less than the ACL graft should be carefully applied on ST during fixation to avoid stress shielding of the graft.
Effect of retrograde condensation and stress sensitivity on properties of condensate gas reservoirs
Authors: Li Nan , Li Haosen , Tan Xianhong , Zhang Lijun , Liu Yuwei
Published: January 2023

In the production process of low permeability condensate gas reservoir, the reverse condensate action and stress sensitivity will lead to the decrease of reservoir permeability and gas well productivity. However, there are few studies on the effect of retrograde condensation and stress sensitivity on permeability. In this study, the stress-sensitive experiments using the method with constant confining pressure but variable inner pressure were carried out on three cores from the BZ gas field in southwestern Bohai Sea. The test result that use the nitrogen as the experimental fluid represent the effect of core skeleton damage on reservoir permeability during formation pressure drop, and the test result that use the condensate gas as the experimental fluid represent the effect of core skeleton damage and retrograde condensation on reservoir permeability. The results reveal that when the formation pressure drops to the dew point pressure, retrograde condensation damage is the main cause of permeability decline. And the effects of core skeleton damage will increase as the formation pressure drops and exceed the retrograde condensation damage when the net stress is greater 7 MPa. When the net stress reaches 20 MPa, the core skeleton damage accounts for more than 90% of the total damage. Furthermore, the gas well production was calculated considering stress sensitivity and retrograde condensation based on the experimental results, the result shows that gas well production decreases by 97.65% when retrograde condensation is considered. This study can provide a reference for quantitative evaluation of the retrograde condensation and stress sensitivity in the production process of condensate gas reservoir.
Better oral hygiene is associated with a reduced risk of cataract: A nationwide cohort study
Authors: Park Jung-Hyun , Lee Heajung , Kim Jin-Woo , Song Tae-Jin
Published: January 2023

Objective

To investigate the association of oral health status and oral hygiene behaviors with cataract occurrence longitudinally.

Materials and methods

Based on the National Health Screening cohort database of Korea, participants who underwent oral health screening by dentists in 2003 were included. Cataract was defined as two or more claims of disease classification for the International Classification of Diseases-10 (E10.34, E11.34, E12.34, E13.34, E14.34, H25, and H26) with cataract specific treatment or surgery procedure claim codes. The occurrence of cataract was analyzed with Cox proportional hazard model according to the presence of periodontitis and oral health examination findings, including missing teeth, caries, tooth brushing, and dental scaling.

Results

Overall, 103,619 subjects were included. During a median follow-up of 12.2 years, cataract developed in 12,114 (11.7%) participants. Poor oral health status such as the presence of periodontitis (adjusted hazard ratio [HR] 1.08, 95% CI [confidence interval] 0.99–1.17, p = 0.088) and increased number of missing teeth (adjusted HR = 1.74, 95% CI = 1.55–1.96, p < 0.001) was associated with the increased cataract risk. Better oral hygiene behaviors such as increased frequency of tooth brushing (adjusted HR = 0.84, 95% CI = 0.79–0.88, p < 0.001) and performed dental scaling within 1 year (adjusted HR = 0.90, 95% CI = 0.86–0.94, p < 0.001) were negatively associated with cataract occurrence.

Conclusion

Periodontitis and increased number of missing teeth may increase the risk of cataract. However, maintaining good oral hygiene through tooth brushing and dental scaling may reduce the risk of future cataract occurrence. Further studies should be performed to confirm the association between chronic oral inflammation and cataract.
Supply chain concentration and corporate financialization
Authors: Zou Meifeng , Zhang Xindong
Published: January 2023

We investigate whether firms that rely on major suppliers or customers, which is defined as supply chain concentration, tend to hold more financial assets than other firms due to supply chain pressure. We find that firms with a higher supply chain concentration have a higher financialization level. The firms' competitive power reduces their financialization level but cannot reverse the adverse impact of supply chain concentration. Furthermore, we explore the mechanism underlying the relationship between supply chain concentration and corporate financialization using the mediation effect method. We find that supply chain concentration impairs firms' main business profitability, leading firms to hold more financial assets. The main business profitability channels play partial mediating roles. Our findings reveal that overdependence on large suppliers/customers causes firms to escape reality and adopt virtual economics.
The prevalence of and risk factors for restless legs syndrome: A nationwide study
Authors: AlShareef Saad Mohammed
Published: January 2023

Objectives

Restless legs syndrome (RLS) is a neglected diagnosis, and most individuals with RLS do not access effective therapies. There has yet to be a nationwide study of the prevalence of and associated risk factors for RLS in Saudi Arabia.

Materials and methods

A population-wide survey was administered to Saudi Arabian adults to assess RLS prevalence and its association with other clinical and demographic variables. RLS was defined according to 2012 IRLSSG Diagnostic Criteria. Persistent RLS was defined as symptoms occurring more than a few nights each week, and RLS causing significant daytime impairment was defined as symptoms causing “severe” excessive daytime sleepiness measured by the Epworth Sleepiness Scale. Associations were evaluated using univariate analyses and binary logistic regression.

Results

10,106 individuals completed the survey. Persistent RLS was reported in 11.9% of participants, which caused significant daytime impairment in 1.2% of participants. In multivariable analysis, younger age (OR 0.96, 95% CI 0.95–0.97; p < 0.001), tobacco smoking (OR 1.28, 95% CI 1.07–1.53; p = 0.008), anxiety (OR 1.34–1.42; p < 0.05), and moderate to severe depressive symptoms (OR 1.52–2.40; p < 0.01) were associated with persistent RLS. Younger age (OR 0.96, 95% CI 0.93–0.99; p = 0.015), female gender (OR 2.28, 95% CI 1.32–3.94; p = 0.003), and moderately severe to severe depressive symptoms (OR 13.59 and 26.7, respectively; p < 0.001) were independently associated with RLS causing significant daytime impairment.

Conclusion

RLS is common in adults in Saudi Arabia and is often co-morbid with moderate to severe depressive symptoms. Both RLS and depression represent a silent epidemic in Saudi Arabia requiring active inquiry by all healthcare workers to reduce their burden and impact.