bluuebunny/crossref_metadata_2025 huggingface dataset:
Angiomatoid Fibrous Histiocytoma Initially Misdiagnosed as Elastofibroma Dorsi: A Case Report and Literature Review
Authors: Jung Soyeon
Published: October 2024

Background and Objectives: Angiomatoid fibrous histiocytoma (AFH) is a rare soft-tissue tumor with a low-grade malignancy. It typically arises in superficial soft tissues of the extremities, head, neck and trunk in children or young adults. Because of its rare entity, it tends to be confused and misdiagnosed. Materials and Methods: A 12-year-old male presented with a painless mass located on his right upper back. The CT finding showed a 7.3 × 2.8 × 5.4 cm-sized, well-defined heterogeneous soft tissue mass in the right infrascapular area. We performed a complete excision, including the surrounding capsule. Result: The final pathology revealed an AFH of intermediate malignancy. On pathologic examination, the lesion was a 5.8 × 4.5 × 2.6 cm-sized mass with a mitotic count of 12/10 HPF, tumor necrosis of 0% and marked increased cellularity and spindle cell morphology. The immunohistochemical study showed negative for S100 and positive for SMA, focal positive for Ki-67, CD68 and positive for CD99, Desmin staining. During the five years of follow-up period, he did not show any evidence of recurrence. Conclusions: The result was satisfactory. We report a case of AFH of the back initially misdiagnosed as an elastofibroma dorsi (ED) with the review of the literature for this uncommon entity.
Theoretical Study of the Influence of Electroconvection on the Efficiency of Pulsed Electric Field (PEF) Modes in ED Desalination
Authors: Nikonenko Victor , Uzdenova Aminat , Kovalenko Anna , Urtenov Makhamet
Published: October 2024

Pulsed electric field (PEF) modes of electrodialysis (ED) are known for their efficiency in mitigating the fouling of ion-exchange membranes. Many authors have also reported the possibility of increasing the mass transfer/desalination rate and reducing energy costs. In the literature, such possibilities were theoretically studied using 1D modeling, which, however, did not consider the effect of electroconvection. In this paper, the analysis of the ED desalination characteristics of PEF modes is carried out based on a 2D mathematical model including the Nernst–Planck–Poisson and Navier–Stokes equations. Three PEF modes are considered: galvanodynamic (pulses of constant electric current alternate with zero current pauses), potentiodynamic (pulses of constant voltage alternate with zero voltage pauses), and mixed galvanopotentiodynamic (pulses of constant voltage alternate with zero current pauses) modes. It is found that at overlimiting currents, in accordance with previous papers, in the range of relatively low frequencies, the mass transfer rate increases and the energy consumption decreases with increasing frequency. However, in the range of high frequencies, the tendency changes to the opposite. Thus, the best characteristics are obtained at a frequency close to 1 Hz. At higher frequencies, the pulse duration is too short, and electroconvective vortices, enhancing mass transfer, do not have time to develop.
Experimental and Numerical Characterization of Local Properties in Laser-Welded Joints in Thin Plates of High-Strength–Low-Alloy Steel and Their Dependence on the Welding Parameters
Authors: Riofrío Patricio G. , Barrionuevo Germán Omar , Olmedo Fernando , Debut Alexis
Published: October 2024

Laser welding on thin plates of high-strength steel is increasing in various industrial applications. The mechanical behavior of welded joints depends on their local properties, which in turn depend on the welding parameters applied to join the base material. This work characterizes the local properties of butt-welded joints of thin plates of high-strength–low-alloy (HSLA) steel. This study focuses on the effect of welding parameters on the microstructure, tensile response, microhardness, and weld bead profile. For this purpose, a factorial experimental design was formed, covering a heat input range from 53 to 75 J/mm. This study identified the main effects and interactions of welding speed and laser power on the weld bead profile and on its width. The microstructure, weld bead width, hardness, and tensile mechanical properties were significantly influenced by heat input. Furthermore, numerical simulations on real weld bead profiles revealed high values of the stress concentration factor and suggested a correlation with heat input.
Comparative Study on the Liquid Metal Embrittlement Susceptibility of the High-Si Advanced High-Strength Steel with EG and GA Zn Coatings
Authors: Gu Jingyi , Zhou Jiayi , Hu Rongxun , Sun Yu , Lei Ming , Gao Yulai
Published: October 2024

The Zn-coated high-Si advanced high-strength steel (AHSS) tends to suffer Zn-assisted liquid metal embrittlement (LME) during the resistance spot welding (RSW) process. In this study, the LME behaviors of electrogalvanized (EG) and galvannealed (GA) high-Si steels were comparatively investigated. The maximum lengths of the LME cracks at the shoulder and center of the spot weld were approximately 366.6 μm and 1486.5 μm, respectively, for the EG yet 137.0 μm and 1533.3 μm, respectively, for the GA high-Si steels. Additionally, all EG and GA welded joints were etched to measure the nugget size. It was found that the increased welding current could aggravate the formation tendency of the LME cracks for both the EG and GA high-Si steels. Furthermore, the statistical results revealed that the electrogalvanized high-Si AHSS exhibited a relatively higher LME susceptibility than the galvannealed high-Si AHSS. It was deemed that the internal oxidation produced during the annealing before the Zn coating was the crucial factor that led to the difference in the LME susceptibilities for the EG and GA high-Si steels.
Reverse Hall–Petch Effect of Nano-Bainite in a High-Carbon Silicon-Containing Steel
Authors: Zhang Xin , Shao Zixuan , Sun Muqun , Cui Tianyu , Liu Qingsuo , Han Jian
Published: October 2024

High-strength steels are widely used in various mechanical production and construction industries for their low cost, high strength and high toughness. Among these, bainitic steels have better comprehensive performance relative to martensite and ferrite. In this paper, from the point of view of its microscopic fine structure and mechanical properties, the high-carbon silicon-containing steel Fe-0.99C-1.37Si-0.44Mn-1.04Cr-0.03Ni was austenitized at high temperature after a brief isothermal treatment at 280 °C and is briefly reviewed. We have used EBSD, TEM and 3D-APT to observe a unique transformation in which high-carbon silicon-containing steels form nanostructured bainite with nanometer widths. Intriguingly, as the isothermal duration decreases, the beam bainite width becomes increasingly finer. When the beam bainite width falls below 50 nm, there is a sudden shift in defect type from the conventional edge-type dislocations to a defect characterized by the insertion of a semi-atomic surface in the opposite direction, which leads to different degrees of reduction in the micro- and macro-mechanical properties of high-carbon silicon-containing steels from 1754 MPa to 1667 MPa. This sudden change in the sub-structural properties is typical of the reverse Hall–Petch effect.
Microstructure and Properties of 7050-T74 Aluminum Alloys with Different Zn/Mg Ratios
Authors: Xiao Daihong , He Zongzheng , Huang Lanping
Published: October 2024

Aluminum alloy 7050-T74 with varying zinc-to-magnesium (Zn/Mg) mass fractions was synthesized using melt casting and hot extrusion techniques. This study investigated the influence of different Zn/Mg ratios on the microstructure, mechanical properties, and corrosion resistance of the alloy. Light microscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), tensile testing, and corrosion testing were employed as analytical methods. The findings indicate that as the Zn/Mg ratio increases from 2.36 to 3.84, the proportion of low-angle boundaries (LABs) within the alloys initially rises and then decreases, achieving a balance between high strength and favorable elongation. Specifically, at a Zn/Mg ratio of 2.72, the alloy exhibits a tensile strength of 641 MPa, a yield strength of 609 MPa, and an elongation of 10.1%. Additionally, increasing the Zn/Mg ratio to 2.90 slightly reduces intergranular corrosion resistance while enhancing exfoliation corrosion resistance.
A Transition State Theory-Based Continuum Plasticity Model Accounting for the Local Stress Fluctuation
Authors: Zheng Yongjia , Wang Hongwei , Zhou Xiangyu , Tang Ding , Wang Huamiao , Wang Guoliang , Wu Peidong , Peng Yinghong , Jiang Yaodong
Published: October 2024

Based on the transition state theory, a continuum plasticity theory is developed for metallic materials. Moreover, the nature of local stress fluctuation within a material point is considered by incorporating the probability distribution of the stresses. The model is applied to investigate the mechanical behaviors of 316 L stainless steel under various loading cases. The simulated results closely match the results obtained by the polycrystal plasticity model and experiments. The mechanical behaviors associated with strain rate sensitivity, temperature dependence, stress relaxation, and strain creep are correctly captured by the model. Furthermore, the proposed model successfully characterizes the Bauschinger effect, which is challenging to capture with a conventional continuum model without additional assumptions. The proposed model could be further employed in the design, manufacturing, and service of engineering components.
Anti-Diabetic Effects of Oleuropein
Authors: Iantomasi Michael , Terzo Matthew , Tsiani Evangelia
Published: October 2024

Background/Objectives: Oleuropein, a secoiridoid polyphenol found in olive oil as well as the fruit and leaves of the olive tree, has been reported to have antioxidant, cardioprotective, anti-inflammatory, anti-cancer, and anti-diabetic properties. Type 2 diabetes mellitus (TD2M) is a chronic metabolic disease characterized by impaired insulin action, termed insulin resistance. The development of T2DM is closely associated with obesity and chronic low-grade inflammation. In recent years, a rise in sedentary lifestyles and diets rich in refined carbohydrates and saturated fats has contributed to an increase in the prevalence of obesity and TD2M. Currently, the strategies for treating T2DM and its prevention lack efficacy and are associated with adverse side effects. Hence, there is an urgent need for novel treatment strategies, including naturally occurring compounds possessing hypoglycemic and insulin-sensitizing properties. Methods: This review summarizes the evidence of the anti-inflammatory and anti-diabetic properties of oleuropein from in vitro and in vivo animal studies, as well as the available clinical trials. Results: The existing evidence indicates that oleuropein may exert its anti-inflammatory effects by downregulating the levels of pro-inflammatory cytokines in hepatic and adipose tissue. Additionally, the evidence suggests that oleuropein targets skeletal muscle and enhances glucose uptake and its related protein signalling cascades, improving glucose tolerance and insulin sensitivity. Conclusions: Despite the evidence of oleuropein’s anti-inflammatory and anti-diabetic potential, more animal and clinical studies are needed to proceed towards its clinical/therapeutic use for metabolic diseases confidently.
Simultaneously Detecting the Power and Temperature of a Microwave Sensor via the Quantum Technique
Authors: Zhang Zhenrong , Jin Yuchong , Tang Jun , Liu Jun
Published: October 2024

This study introduces a novel method for the simultaneous detection of microwave sensor power and temperature, leveraging nitrogen-vacancy (NV) centers as a robust quantum system. Through precise measurement of the optical detection magnetic resonance contrast in NV centers, the microwave power is accurately determined. Furthermore, the temperature of the sensor is obtained by monitoring the variations in zero-field splitting and thorough spectral analysis. This method enables the efficient real-time acquisition of synchronized data on both microwave power and temperature from the sensor, facilitating concurrent monitoring without the necessity of additional sensing devices. Finally, we verified that the magnetic sensitivity of the system is approximately 1.2 nT/Hz1/2, and the temperature sensitivity is around 0.38 mK/Hz1/2. The minimum resolution of microwave power is about 20 nW. The experimental results demonstrate that this quantum measurement technique provides stable and accurate data across a wide range of microwave power and temperature conditions. These findings indicate substantial potential for this technique in advanced applications such as aerospace, medical diagnostics, and high-frequency communications. Future studies will aim to extend the industrial applicability of this method by refining quantum control techniques within NV center systems.
Pullulan/Collagen Scaffolds Promote Chronic Wound Healing via Mesenchymal Stem Cells
Authors: Tören Elçin , Mazari Adnan Ahmed
Published: October 2024

This study investigated the development of Pullulan/Collagen nanofiber scaffolds integrated with mesenchymal stem cells (MSCs) to enhance chronic wound healing. The combination of these biopolymers aims to optimize the scaffold properties for cell growth, viability, and tissue regeneration. Materials and Methods: Pullulan, Collagen, and Pullulan/Collagen composite nanofibers were fabricated using electrospinning. The fibers were characterized using scanning electron microscopy (SEM) to determine the fiber diameter, and Fourier-transform infrared spectroscopy (FTIR) was employed to assess the molecular interactions. Cell viability was evaluated using MSCs cultured on the scaffolds and apoptosis assays were conducted to assess cell health. Distilled water was used as the solvent to maximize biocompatibility. Results: SEM analysis revealed that Pullulan nanofibers exhibited a larger average diameter (274 ± 20 nm) compared to Collagen fibers (167.03 ± 40.04 nm), while the Pullulan/Collagen composite fibers averaged 280 ± 102 nm. FTIR confirmed the molecular interactions between Pullulan and Collagen. Regarding biocompatibility, the Pullulan/Collagen scaffold demonstrated superior cell viability at 99% compared to 91% for Pullulan alone. Apoptosis assays indicated significantly lower necrosis rates for the composite scaffold (1.29%) than for the Pullulan-only scaffolds (2.35%). Conclusion: The use of distilled water as a solvent played a critical role in increasing cell viability and facilitating healthy proliferation of MSCs without cellular damage. Additionally, the reduced platelet activation and macrophage activity (0.75-fold for both) further supported the biocompatibility of the Pullulan/Collagen scaffold, demonstrating its potential for tissue engineering and chronic wound healing applications.
Dietary Administration Effects of Microbial Exopolysaccharide from Bacillus subtilis P1 on Growth Performance and Immunity in Nile Tilapia (Oreochromis niloticus)
Authors: Bunkaew Kannika , Yenraksa Auraiwan , Pewhom Akkanee , Kiriratnikom Suphada , Sewaka Mariya , Lertworapreecha Monthon , Chanasit Wankuson
Published: October 2024

Exopolysaccharide (EPS)-producing bacteria were isolated from the intestines of freshwater fish as prebiotics. Among the isolates, Bacillus sp. P1 was the potent EPS producer, with a high EPS production, and was then identified as Bacillus subtilis P1 based on 16S rRNA and biochemical characteristics. The produced microbial EPS was characterized by its functional groups by FTIR, showing a 90.20% correlation to inulin, while the EPS molecular weight was approximately 105 Da with a high PDI (>1.5). Moreover, the EPS from B. subtilis P1 was assessed for prebiotic properties by growing probiotic bacteria, and significant cell growth occurred in sugar-free TSB with 0.5% EPS (p < 0.05). EPS exhibited approximately 55.37% DPPH radical scavenging at 20 mg/mL and inhibited certain fish pathogens at 400 μg/mL (10–13 mm inhibition zone). Low EPS cytotoxicity was confirmed (<1% hemolysis) prior to use as immunobiotics in Nile Tilapia (Oreochromis niloticus) diet supplementation. Nile tilapia growth and immune response were monitored after feeding with control (C), basal diet (BD), and treatment (T): BD + EPS 5 g/kg. In the T-group, the weight gain (WG), % specific growth rate (SGR), and average daily gain (ADG) significantly increased compared to the control (p < 0.05) by week 4, with no negative effects on blood chemistry parameters. Lysozyme activity and respiratory burst activity in T-groups were significantly higher than the control (p < 0.05), with a 50% RLP survival rate of Nile Tilapia infected by Aeromonas veronii in the T-group after a two-week challenge. On the other hand, the proximate analysis revealed higher protein content in the T-group. These findings suggest that EPS from B. subtilis P1 in fish diets efficiently supports fish growth and stimulates innate immune response in Nile Tilapia, thus showing potential as the immunobiotics for aquaculture.
A Novel Deinococcus Antioxidant Peptide Mitigates Oxidative Stress in Irradiated CHO-K1 Cells
Authors: Lim Sangyong , Song Ha-Yeon , Park Hae Ran , Ahn Ki Bum
Published: October 2024

Reactive oxygen species (ROS), byproducts of cellular metabolism and environmental factors, are linked to diseases like cancer and aging. Antioxidant peptides (AOPs) have emerged as effective countermeasures against ROS-induced damage. The Deinococcus genus is well known for its extraordinary resilience to ionizing radiation (IR) and possesses complex antioxidant systems designed to neutralize ROS generated by IR. In this study, we developed four peptides, each containing 9 to 11 amino acids, from the leaderless mRNA (lmRNA) sequences of D. deserti. Lacking a 5′ untranslated region, lmRNAs directly initiate protein synthesis, potentially encoding small peptides such as AOPs. Of the four peptides, Ddes-P3 was found to exhibit significant antioxidant capabilities in vitro, effectively scavenging ABTS radicals. Ddes-P3 provided considerable defense against IR-induced oxidative stress in CHO-K1 cells, demonstrating a notable reduction in ROS production and lipid peroxidation. The peptide’s potential was highlighted by its ability to enhance cell survival and maintain mitochondrial membrane potential under irradiative stress, suggesting its utility as a nontoxic and effective radioprotector in mitigating radiation-induced cellular damage. This study explores the potential role of lmRNA in synthesizing AOPs within Deinococcus. Identifying lmRNAs that encode AOPs could deepen our understanding of their cellular resistance to oxidative stress and pave the way for creating innovative biotechnological and therapeutic AOPs.
Experimental Infections of Pigs with Japanese Encephalitis Virus Genotype 4
Authors: Hick Paul M. , Finlaison Deborah S. , Parrish Kate , Gu Xingnian , Hayton Philip , O’Connor Tiffany , Read Andrew , Zhang Jing , Spiers Zoe B. , Pinczowski Pedro , Ngo Angel L. , Kirkland Peter D.
Published: October 2024

The emergence of Japanese encephalitis virus (JEV) in eastern Australia in 2022 caused extensive reproductive disease in pigs and is a threat to public health. Groups of weaned piglets were experimentally infected with the Australian outbreak strain of JEV (genotype 4). All pigs challenged at 5 weeks of age were infected after an intradermal injection of 1 × 105.5 (n = 4) or 1 × 104.5 TCID50/pig (n = 5). Intranasal instillation was less effective at this age, infecting 3/4 pigs with the same higher dose and 1/5 with the lower dose. Intradermal injection using 1 × 105.0 TCID50/pig also infected 9/9 pigs at 11 weeks of age. Infection in all cases was confirmed by qRT-PCR of blood samples, which identified a viremia peak at 3–4 days and detected JEV-specific antibodies as early as 5 days after the challenge. The detection of JEV in oral and nasal swabs and in saliva from chew ropes was less consistent. JEV was detected in the tonsils of 21/22 infected pigs and was isolated from the tonsils of 9/9 pigs sampled 19 days after the challenge at 11 weeks of age. The infected pigs showed no clinical signs other than pyrexia on Days 4–6. Histopathology consistent with JEV infection was evident in the nervous tissues of all but two pigs sampled 28 days after the challenge and was characterized by meningitis, encephalitis and gliosis throughout the brain. Serological studies showed extensive cross-reactivity between JEV and Murray Valley encephalitis virus using blocking ELISAs. However, the determination of limiting-dilution titres allowed for the identification of the infecting virus. This in vivo infection model will be useful in evaluating JEV vaccines and for comparative pathogenesis studies with other JEV genotypes.
Gut Microbiome Diversity and Composition in Captive Siberian Tigers (Panthera tigris altaica): The Influence of Diet, Health Status, and Captivity on Microbial Communities
Authors: Lee You-Jeong , Lee Saebom , Kim Beoul , Kwak Dongmi , Kim Taehwan , Seo Min-Goo
Published: October 2024

The gut microbiome is essential for the health of carnivorous mammals, including the endangered Siberian tiger (Panthera tigris altaica). However, limited research exists on the gut microbiome of captive Siberian tigers, especially regarding how diet and health status influence microbial diversity. This study addresses this gap by investigating the gut microbiome diversity and composition of six captive-born Siberian tigers housed at the Baekdudaegan National Arboretum in South Korea, using 16S rRNA gene sequencing. The study aimed to examine how diet and health status influence microbial communities, providing baseline data for managing captive tigers. Alpha diversity analysis revealed significant variation in microbial richness and evenness, with Tigers 2 and 6 exhibiting the highest microbial diversity and Tiger 3 the lowest, likely due to its surgical history and limited diet. Beta diversity analysis showed distinct microbial community structures influenced by diet and health. Taxonomic profiling identified Firmicutes and Bacteroidota as the dominant phyla, with Clostridium sensu stricto more prevalent in healthier tigers, while Escherichia-Shigella and Proteobacteria were abundant in tigers with lower diversity, suggesting dysbiosis. Comparisons with other tiger species confirm that diet, health, and captivity significantly shape the gut microbiome. These findings highlight the need for personalized health management in captive environments.
Subsurface Faults and Magma Controls on the Jinchuan Ni-Cu Sulfide Deposit: Constraints from Magnetotelluric Data
Authors: Chen Chutong , Fan Junjie , Liu Huilong , Guo Chang’an , Zhang Lingxiao , Yuan Weiheng , Yang Guicai , Wang Bin , Zhang Yinglei , Li Yangming , Wang Kunpeng
Published: October 2024

The Jinchuan Ni-Cu sulfide deposit in the Longshoushan terrane is among the world’s largest magmatic sulfide deposits. This study uses magnetotelluric (MT) survey data imaging combined with previous geophysical data to investigate Segment III of the deposit. The image of MT data reveals a significant low-resistivity anomaly ~200 m beneath Segment III, aligning with known ore bodies, and an additional anomaly to the north, indicating further exploration potential. These findings highlight the deep-seated intrusions and their connection to surface mineralization, emphasizing the critical role of ultramafic rock encapsulation and fault-controlled morphology in ore body formation. The newly identified northern anomaly, resembling the Segment III ore bodies, suggests a promising target for future exploration. Integrating MT surveys with other geophysical methods enhances the understanding of subsurface structures and mineralization, providing a robust framework for discovering concealed mineral deposits and improving exploration efficiency.
Enhanced Flotation Separation of Iron and Silicon with Branched Block Polyethylene Oxide Polypropylene Oxide and Sodium Oleate: Mechanisms and Flotation Behavior
Authors: Jiang Yongliang , Sun Chunbao , Kou Jue
Published: October 2024

This study explores the strengthening mechanism of the surfactant branched block polyethylene oxide–polypropylene oxide (BB-PEO-PPO) in sodium oleate (NaOL) flotation systems. A comprehensive characterization of BB-PEO-PPO was performed using flotation experiments, contact angle measurements, surface tension analysis, zeta potential measurements, infrared spectroscopy, and foam dynamics assessments. Flotation results showed that the combination of BB-PEO-PPO and NaOL improved iron recovery by 2.71% and reduced the total iron (TFe) grade in tailings by 2.05%, demonstrating a significant enhancement in collecting efficiency. The addition of BB-PEO-PPO effectively reduced foam size and lowered the zeta potential on the surface of activated quartz. At a slurry temperature of 15 °C, BB-PEO-PPO increased the solubility of NaOL radicals, facilitating their chemical adsorption onto activated quartz and improving the hydrophobicity of quartz particles. Notably, the presence of BB-PEO-PPO extended the flotation foam discharge time (D50) by 50% without substantially increasing foam volume, thereby significantly enhancing foam stability.
Peridotite Weathering and Ni Redistribution in New Caledonian Laterite Profiles: Influence of Climate, Hydrology, and Structure
Authors: Cathelineau Michel , Teitler Yoram , Grimaud Jean-Louis , Favier Sylvain , Golfier Fabrice , Ramanaidou Erick , Grangeon Sylvain , Kerreveur Yohann , Jeanpert Julie , Étienne Samuel , Muñoz Manuel , Ulrich Marc
Published: October 2024

The peridotite massifs of New Caledonia are characterised by complex hydrodynamics influenced by intense inherited fracturing, uplift, and erosion. Following the formation of the erosion surfaces and alteration processes, these processes drive chemical redistribution during weathering; particularly lateritisation and saprolitisation. Magnesium, silica, and trace elements such as nickel and cobalt—released as the dissolution front advances—are redistributed through the system. New observations and interpretations reveal how lateritic paleo-land surfaces evolved, and their temporal relationship with alteration processes since the Oligocene. Considering the geometry of discontinuity networks ranging from micro-fractures to faults, the transfers occur in dual-permeability environments. Olivine dissolution rates are heterogeneously due to differential solution renewal caused by erosion and valley deepening. Differential mass transfer occurs between mobile regions of highly transmissive faults, while immobile areas correspond to the rock matrix and the secondary fracture network. The progression of alteration fronts controls the formation of boulders and the distribution of nickel across multiple scales. In the saprolite, nickel reprecipitates mostly in talc-like phases, as well as minor nontronite and goethite with partial diffusion in inherited serpentine. The current nickel distribution results from a complex interplay of climatic, hydrological and structural factors integrated into a model across different scales and times.
A Comparative Effect of Sustainable Materials on the Immobilization, Geochemical Fractions, Bioaccumulation, and Translocation of Ni in Smelter- and Mine-Polluted Soils
Authors: Lahori Altaf Hussain , Ahmed Samreen Riaz , Afzal Ambreen , Mierzwa-Herstek Monika , Umar Aqsa , Muhammad Maria Taj , Vambol Viola , Saleem Irfan , Tanoli Abrar Ahmad , Vambol Sergij
Published: October 2024

The present study holds significant implications, as it aims to investigate the comparative effect of biochar, zeolite, and bentonite minerals on the stabilization of Ni fractions, bioaccumulation, translocation indices, and the reduction in their absorption by pakchoi in smelter- and mine-contaminated soils. The results, which are of great interest, showed that the maximum fresh and dry biomasses of pakchoi were observed up to 28.21 and 18.43% for smelter-polluted soil and 61.96 and 67.90% for mine-contaminated soil amended with zeolite compared to the control. Applying zeolite increased pakchoi chlorophyll SPAD values 1.17-fold in smelter soil and 1.26-fold in mine-polluted soil. The highest Ni immobilization in smelter and mine soil was observed at 76.8 and 85.38% with the application of bentonite, which increased soil pH and CEC. The application of biochar, bentonite, and zeolite reduced the Ni residual, oxidizable, and acid-soluble fractions, but biochar and bentonite increased the reducible fraction of Ni in smelter soil. The highest reduction in Ni in the shoot and root was noted as 82.08 and 68.28% of smelter-polluted soil and 77.25 and 89.61% of mine-polluted soil with bentonite compared to control soil. Overall, it has been concluded that biochar, zeolite, and bentonite can be successfully used to mitigate the Ni concentration in smelter- and mine-polluted soil and reduce uptake by vegetable crops.
The Influence of Fluoride Ions on the Forms of Lanthanide Migration in Natural and Polluted Waters of the Lovozero Massif (The Kola Peninsula)
Authors: Mazukhina Svetlana , Drogobuzhskaya Svetlana , Masloboev Vladimir , Sandimirov Sergey , Krasavtseva Eugenia , Pozhilenko Vladimir
Published: October 2024

A comprehensive study (monitoring, thermodynamic modeling) of natural and anthropogenically polluted waters of the Lovozero Massif has been carried out. A thermodynamic study of the weathering of the Lovozero Massif within the “water-rock-atmosphere” system at a temperature of 5 °C showed that the elements contained in the rocks of the studied massif influence the formation of the chemical composition of natural waters. It has been established that an increase in the degree of “water-rock” interaction leads to an increase in the concentrations of F−, Cl−, SO42−, and HCO3− in the solution. This affects the mobility of lanthanum, cerium, and other elements due to the formation of complex compounds with them. The relatively high content of fluorine, phosphorus, and HCO3− (weak and medium acids) in the solution promotes the dissolution of silicates while Si, Al, and P are released into the solution. Monitoring of water from a flooded mine in which there is an increase in the degree of interaction of water with rock showed higher pH values for the concentrations of Na, HCO3−, F−, P, Al, Si, V, U, La, and Ce. The conclusions are relevant in the context of the use of groundwater for drinking water supply purposes. The obtained information is useful to evaluate the health of the population of the region under study.
The Geological Characteristics, Resource Potential, and Development Status of Manganese Deposits in Africa
Authors: Guo Xinlian , Lu Yiguan , Zhang Qizuan , Ren Junping , Cai Weimin
Published: October 2024

Manganese is a critical metal extensively used in steel production, battery manufacturing, and the chemical industry. Manganese deposits are widely distributed globally, with African manganese deposits holding a particularly significant position. This study provides a comprehensive overview of the current status of manganese resources in Africa and analyzes the main types and genesis of the deposits. It also explores the significance of African manganese resources within the global manganese industry and examines the exploration, development, production, and trade status of African manganese ore, revealing dynamic changes and trends within the industry. Africa plays a key role in global manganese resources, with its reserves and resources accounting for 69% and 51% of the global totals, respectively. South Africa is the largest manganese producer, while Gabon and Ghana are also important countries in terms of manganese resources. Based on the host rock and genetic types, African manganese deposits primarily include banded iron formation (BIF)-hosted, black shale-hosted, karst-hosted, and volcanic sedimentary deposits. Additionally, manganese exploration projects in Africa are active, with significant production growth in South Africa and Gabon, and Africa’s standing in the global manganese market is steadily increasing. Trade data also indicate that South Africa dominates manganese exports in Africa and globally. Despite fluctuations in global export volumes, African manganese exports remain high. The prospects for Africa’s manganese industry are promising, and further strengthening of manganese exploration and development will help enhance Africa’s influence in the global manganese market, making a more significant contribution to global industrial and economic development.
Two-Step Clustering for Mineral Prospectivity Mapping: A Case Study from the Northeastern Edge of the Jiaolai Basin, China
Authors: Chang Xiaopeng , Zhang Minghua , Zhang Xiang , Zhang Sheng
Published: October 2024

The advancement of geological big data has rendered data-driven methodologies increasingly vital in Mineral Prospectivity Mapping. The effective integration of quantitative and qualitative data, including experiential and knowledge-based insights, is crucial in geological data fusion. Specifically, the conversion of raw data into samples and the selection of predictive methods are two core issues that constitute the focus of this study. Traditional clustering methods require the user to specify the number of clusters in advance. The two-step clustering can automatically determine the clustering result ‘k’ while analyzing both continuous and categorical variables, by building a Cluster Feature (CF) and using information criteria to merge nodes. In this study, we conducted an analysis utilizing stream sediment element data, residual gravity anomalies, and fault distribution through the two-step clustering method. Factor analysis (FA) was employed to reduce 16 elemental variables from stream sediments into five uncorrelated continuous variables; additionally, residual gravity anomalies were transformed from continuous to categorical variables via an interval-based method before being combined with fault distribution, resulting in seven variables for clustering. The research findings indicate that categorical variables significantly influence clustering results; concurrently, as the importance of continuous variables within the cluster increases, so does k. When only one categorical variable is present, residual gravity anomalies show significantly better clustering than fault distribution; however, when two categorical variables are involved, it is essential to consider the quantity of categories: more categories lead to poorer quality. The results from the Jiaolai Basin’s northeastern margin indicate a significant correlation with known gold deposits; two-step clustering is a promising and effective method for improving mineral prospecting efforts.
Seasonal Variations in Ochreous Precipitates and Drainage Waters in the Grantcharitsa Tungsten Deposit, Western Rhodopes, Bulgaria
Authors: Tarassov Mihail , Tarassova Eugenia , Lyubomirova Valentina , Stavrev Milen , Tacheva Elena , Benderev Aleksey
Published: October 2024

Seasonal variations of drainage waters and ochreous products of their discharge from the closed abandoned old gallery at the Grantcharitsa scheelite deposit (Bulgaria) were studied by field and laboratory methods for the period 2019–2023. The drainage is generated under anoxic conditions and is inherently diluted (EC = 100–202 µS/cm) with S (6–12 mg/L), Si (6–22 mg/L), Na (6–10 mg/L), Fe (0.2–3.3 mg/L), and W (0.19–3.5 µg/L), at a pH 4.4–6.5 and temperature 7–11.5 °C, with dissolved oxygen DO (2.1–7.7 mg/L). The concentrations of Fe and W and the pH of the water are variable and reach their maximum values during the dry (autumn) season. It was found that such parameters as pH, Eh, DO, Fe and W content change dramatically at a distance of up to 3 m from the water outlet; the values of pH, DO and Eh are sharply increased with a simultaneous nearly 5–6-times reduction in iron and tungsten content. The decrease in the contents of these elements is associated with the precipitation of ochreous material consisting of nanoscale ferrihydrite with an intermediate structural ordering between 2-line and 6-line ferrihydrite (major phase), hematite, goethite, quartz, montmorillonite and magnetite. The formation of ferrihydrite occurs as a result of abiotic and biotic processes with the participation of iron-oxidizing bacteria. Besides Fe2O3 (55.5–64.0 wt.%), the ochreous sediment contains SiO2 (12.0–16.4 wt.%), SO3 (1.3–2.4 wt.%), Al2O3 (3.1–6.8 wt.%) and WO3 (0.07–0.11 wt.%). It has been shown that drainage waters and ochreous sediments do not inherently have a negative impact on the environment. The environmental problem arises with intense snowmelt and heavy rainfall, as a result of which the accumulated sediments are washed away and carried in the form of suspensions into the water systems. It is suggested that by providing atmospheric oxygen access to the closed gallery (via local boreholes), it is possible to stop the generation of iron-enriched drainage.
Synthesis and Evaluation of Phenyltriazole-Deoxynojirimycin Hybrids as Potent α-Glucosidase Inhibitors
Authors: Wang Lin , Luo Wei , Zhao Yonghong , Guo Xinling , Bai Xiangru , Guo Leilei , Zhu Nailiang
Published: October 2024

1-deoxynojirimycin (DNJ) is a well-known α-glucosidase inhibitor. A series of phenyltriazole-deoxynojirimycin hybrids containing C4 and C6 (4 and 6 methylenes, respectively) linkers were synthesized. These novel compounds were assessed for preliminary glucosidase inhibition and cytotoxicity tests in vitro. Among them, compounds 12–14 and 16–20 (IC50: 105 ± 9–11 ± 1 μM) were more active than deoxynojirimycin (DNJ, IC50 = 155 ± 15 μM). The kinetics of enzyme inhibition measured by using Lineweaver–Burk plots indicated that compounds 18 and 19 were competitive inhibitors. In addition, a molecular docking study of α-glucosidase revealed that the interaction modes and the orientations of compound 18 and DNJ were clearly different. Furthermore, in tissue culture, HL60 cell compounds showed no cytotoxicity at low concentrations. When the concentration reached 50 µM, only compound 20 exhibited cytotoxicity. The structure–activity relationships exhibit that the length of the linker and the nature of 4-position substituents on the phenyl have a significant effect on the inhibitory potency of glucosidases and cytotoxicity.
A Comprehensive Review on Polyphenols of White Wine: Impact on Wine Quality and Potential Health Benefits
Authors: Ćorković Ina , Pichler Anita , Šimunović Josip , Kopjar Mirela
Published: October 2024

Polyphenols are associated with various beneficial health effects. These compounds are present in edible plants such as fruits and vegetables, and the human body absorbs them through the consumption of foods and beverages. Wine is recognized as a rich source of these valuable compounds, and it has been well established that polyphenols present in red wine possess numerous biologically active functions related to health promotion. Therefore, most scientific research has been focused on red wine polyphenols, whereas white wine polyphenols have been neglected. This review presents the summarized information about the most abundant polyphenols in white wines, their concentration, their impact on wine quality and their potential health effects, such as neuroprotective and cardioprotective activities, antioxidant potential, antimicrobial activity and their positive effects on lipids. These findings are an effort to help compensate for the relative lack of relevant data in the scientific literature regarding white wine polyphenols.
Design, Synthesis, and Evaluation of Doxifluridine Derivatives as Nitroreductase-Responsive Anticancer Prodrugs
Authors: Zhang Xinmeng , Dong Taimin , Li Xu , Xu Changjie , Chen Fanghui , Wang Shiben , Wang Xuekun
Published: October 2024

Antimetabolite antitumor drugs interfere with nucleic acid and DNA synthesis, causing cancer cell death. However, they also affect rapidly dividing normal cells and cause serious side effects. Doxifluridine (5′-deoxy-5-fluorouridine [5′-DFUR]), a 5-fluorouracil (5-FU) prodrug converted to 5-FU by thymidine phosphorylase (TP), exerts antitumor effects. Since TP is distributed in tumor and normal tissues, 5′-DFUR features side effects. Here we designed a series of novel 5′-DFUR derivatives based on high nitroreductase (NTR) levels in the hypoxic microenvironment of tumor tissues by introducing nitro-containing moieties into the 5′-DFUR structure. These derivatives exert their antitumor effects by producing 5-FU under the dual action of TP and NTR in the tumor microenvironment. The derivatives were synthesized and their stability, release, and cytotoxicity evaluated in vitro and antitumor activity evaluated in vivo. Compound 2c, featuring nitrofuran fragments, was stable in phosphate-buffered saline and plasma at different pH values and reduced rapidly in the presence of NTR. The in vitro cytotoxicity evaluation indicated that compound 2c showed excellent selectivity in the MCF-7 and HT29 cell lines. Moreover, it exhibited antitumor effects comparable to those of 5′-DFUR in vivo without significant toxic side effects. These results suggest that compound 2c is a promising antitumor prodrug.
Photothermal Infrared Radiometry and Thermoreflectance—Unique Strategy for Thermal Transport Characterization of Nanolayers
Authors: Chatterjee Ankur , Swapna Mohanachandran Nair Sindhu , Mikaeeli Ameneh , Khalid Misha , Korte Dorota , Wieck Andreas D. , Pawlak Michal
Published: October 2024

Thermal transport properties for the isotropic and anisotropic characterization of nanolayers have been a significant gap in the research over the last decade. Multiple studies have been close to determining the thermal conductivity, diffusivity, and boundary resistance between the layers. The methods detailed in this work involve non-contact frequency domain pump-probe thermoreflectance (FDTR) and photothermal radiometry (PTR) methods for the ultraprecise determination of in-plane and cross-plane thermal transport properties. The motivation of one of the works is the advantage of the use of amplitude (TR signal) as one of the input parameters along with the phase for the determination of thermal parameters. In this article, we present a unique strategy for measuring the thermal transport parameters of thin films, including cross-plane thermal diffusivity, in-plane thermal conductivity, and thermal boundary resistance as a comprehensively reviewed article. The results obtained for organic and inorganic thin films are presented. Precise ranges for the thermal conductivity can be across confidence intervals for material measurements between 0.5 and 60 W/m-K for multiple nanolayers. The presented strategy is based on frequency-resolved methods, which, in contrast to time-resolved methods, make it possible to measure volumetric-specific heat. It is worth adding that the presented strategy allows for accurate (the signal in both methods depends on cross-plane thermal conductivity and thermal boundary resistance) and precise measurement.
Vertical Electric-Field-Induced Switching from Strong to Asymmetric Strong–Weak Confinement in GaAs Cone-Shell Quantum Dots Using Transparent Al-Doped ZnO Gates
Authors: Alshaikh Ahmed , Peng Jun , Zierold Robert , Blick Robert H. , Heyn Christian
Published: October 2024

The first part of this work evaluates Al-doped ZnO (AZO) as an optically transparent top-gate material for studies on semiconductor quantum dots. In comparison with conventional Ti gates, samples with AZO gates demonstrate a more than three times higher intensity in the quantum dot emission under comparable excitation conditions. On the other hand, charges inside a process-induced oxide layer at the interface to the semiconductor cause artifacts at gate voltages above U≈ 1 V. The second part describes an optical and simulation study of a vertical electric-field (F)-induced switching from a strong to an asymmetric strong–weak confinement in GaAs cone-shell quantum dots (CSQDs), where the charge carrier probability densities are localized on the surface of a cone. These experiments are performed at low U and show no indications of an influence of interface charges. For a large F, the measured radiative lifetimes are substantially shorter compared with simulation results. We attribute this discrepancy to an F-induced transformation of the shape of the hole probability density. In detail, an increasing F pushes the hole into the wing part of a CSQD, where it forms a quantum ring. Accordingly, the confinement of the hole is changed from strong, which is assumed in the simulations, to weak, where the local radius is larger than the bulk exciton Bohr radius. In contrast to the hole, an increasing F pushes the electron into the CSQD tip, where it remains in a strong confinement. This means the radiative lifetime for large F is given by an asymmetric confinement with a strongly confined electron and a hole in a weak confinement. To our knowledge, this asymmetric strong–weak confinement represents a novel kind of quantum mechanical confinement and has not been observed so far. Furthermore, the observed weak confinement for the hole represents a confirmation of the theoretically predicted transformation of the hole probability density from a quantum dot into a quantum ring. For such quantum rings, application as storage for photo-excited charge carriers is predicted, which can be interesting for future quantum photonic integrated circuits.
Glass Surface Nanostructuring by Soft Lithography and Chemical Etching
Authors: Bravo Luciano , Ampuero Martín , Correa-Puerta Jonathan , Corrales Tomás P. , Flores Sofía , Schleyer Benjamín , Hassan Natalia , Häberle Patricio , Henríquez Ricardo , del Campo Valeria
Published: October 2024

Due to its high durability and transparency, soda lime glass holds a huge potential for several applications such as photovoltaics, optical instrumentation and biomedical devices, among others. The different technologies request specific properties, which can be enhanced through the modification of the surface morphology with a nanopattern. Here, we report a simple method to nanostructure a glass surface with soft lithography and wet-chemical etching in potassium hydroxide (KOH) solutions. Glass samples etched with a polymeric mask showed a nanopattern with stripes of widths between 220 and 450 nm and modulated heights between 50 and 200 nm. For different solution concentrations or etching times, the obtained nanopatterns led to an increase or reduction of the water contact angle. The largest increment, ~20 degrees, was achieved by etching the glass for 180 min with 30% KOH concentration, while a super-hydrophilic glass (~9° contact angle) was achieved when etching for 90 min with the same concentration. Optical characterization showed a very low influence of the nanostructured pattern on glass transparency and an increment in UV transmittance for some cases.