bluuebunny/crossref_metadata_2025 huggingface dataset:
Gorham-Stout disease: A multirod lumbar reconstruction with off-label suppression-remission therapy
Authors: Krishnan Ajay , Raj Aditya , Degulmadi Devanand , Mayi Shivanand , Rai Raviranjan , Bali Shiv Kumar , Parmar Vatsal , Amin Prarthan Chirag , Krishnan Preety , Dave Mirant , Dave Bharat
Published: April 2022

Background:

Gorham-Stout disease (GSD), a fibro-lymphovascular entity in which tissue replaces the bone leading to massive osteolysis and its sequelae, rarely leads to spinal deformity/instability and neurological deficits. Here, we report a 12-year-old female who was diagnosed and treated for GSD.

Case Description:

A 12-year-old female presented with back pain, and the inability to walk, sit, or stand attributed to three MR/CT documented L2-L4 lumbar vertebral collapses. Closed biopsies were negative. However, an open biopsy diagnosed GSD. She underwent a dorsal-lumbar-to-pelvis fusion (i.e., T5-T12 through L5/S1/S2) using multilevel pedicle screw/rod stabilization and human leukocyte antigens (HLAs) matched allograft (i.e. from her father). Postoperatively, she was treated with “off-label” teriparatide injections, bisphosphonates, and sirolimus. Four years later, while continuing the bisphosphonate therapy, she remained stable.

Conclusion:

Surgical multirod stabilization from T5 to S2, supplemented with HLA compatible allograft, and multiple medical “off-label” therapies (i.e., teriparatide, sirolimus, and bisphosphonates) led to a good 4-year outcome in a 12-year-old female with GSD.
CHILDREN SCIENCE CENTER
Authors: Nobela Galuh Rizka Fitri , Nurhamsyah Muhammad , Gultom Bontor Jumaylinda
Published: April 2022

Science is a very important science for children to understand, because children are a golden age phase where at their age their brains grow and develop rapidly. The need to learn science from an early age is to avoid their fear in adulthood when it comes to studying science. Many children or teenagers avoid science lessons because for them it is a difficult lesson to understand. Therefore, it is necessary to learn science from an early age to avoid the stereotype that says science is difficult and scary. The Children Science Center was built to help children learn science. The Children Science Center was also built to be a means of learning science outside of school, because many schools in Indonesia have inadequate facilities for studying science. The method used in the Children Science Center is the design method of J.C Jones. Jones started his design from an idea that was equipped with information to strengthen the idea. All information is analyzed, then synthesized to produce certain concepts according to the initial idea and then evaluated. The evaluation stage will be the basis for optimizing the design. This Science Center has a commercial area and is a public space that can provide income and educational recreation for children.
PERANCANGAN KAWASAN SIRKUIT BALAP 150CC PONTIANAK
Authors: Handalan Najmi Zahir , Affrilyno Affrilyno , Nurhamsyah Muhammad
Published: April 2022

Motorsports in Indonesia are growing. This is proven by the increasing number of areas with permanent and/or non-permanent racing circuits with improvements on existing ones. The Sultan Syarif Abdurrahman Pontianak racing circuit was closed since 29 October 2020 until an undetermined time. West Kalimantan and Pontianak City require racing circuits with national standards and adequate facilities. The author's Design of the Pontianak 150cc Racing Circuit Area tries to answer the required racing circuit. The author studied the racing circuit standards which are referenced by IMI, FIM and CIK-FIA also the precedents of racing circuits and race events. An analysis conducted related to the design subject and the facility needs of a racing circuit. The author determines which sites around the city of Pontianak with an adequate area. The design refers to the needs of the 150cc class race which is often held in West Kalimantan Province. The design's concept is arena concept. The design has pit building, medical building and visitor/audience buildings which are placed around the racetrack. With the learning outcomes of circuit standards, circuit precedents and racing event precedents, the design concept can be the beginning of a racing circuit construction needed by West Kalimantan and Pontianak City.
Autonomous Non-Equilibrium Self-Assembly and Molecular Movements Powered by Electrical Energy
Authors: Ragazzon Giulio , Malferrari Marco , Arduini Arturo , Secchi Andrea , Rapino Stefania , Silvi Serena , Credi Alberto
Published: April 2022

The ability to exploit energy autonomously is one of the hallmarks of Life. Mastering such processes in artificial nanosystems can open unforeseen technological opportunities. In the last decades, light- and chemically-driven autonomous systems have been developed in relation to conformational motion and self-assembly, mostly in relation to molecular motors. On the contrary, despite electrical energy is an attractive energy source to power nanosystems, its autonomous exploitation remains essentially unexplored. Herein we demonstrate the autonomous exploitation of electrical energy by a self-assembling system. Threading and dethreading motions of a pseudorotaxane take place autonomously in solution, between the electrodes of a scanning electrochemical microscope. This innovative actuation mode allows operating a molecular machine with an energy efficiency of 9%, unprecedented in autonomous systems. The strategy is general and can be applied to any redox-driven system. Ultimately, our study brings molecular nanoscience one step closer to everyday technology.
A Single Site Mutation Induces a Water-Mediated Promiscuity in Lignin Breaking Cytochrome P450GcoAA Single Site Mutation Induces a Water-Mediated Promiscuity in Lignin Breaking Cytochrome P450GcoA
Authors: Singh Warispreet , Santos Sonia , James Paul , Black Gary , Huang Meilan , Dubey Kshatresh
Published: April 2022

Cytochrome P450 GcoA is an enzyme that catalyses the guaiacol unit of lignin during the lignin breakdown via aryl-O-demethylation reaction. This reaction is intriguing and is of commercial importance for its potential application in the production of biofuel and plastic from biomass feedstock. Recently, the F169A mutation in the P450 GcoA elicits a promiscuous activity for syringol while maintaining the native activity for guaiacol. Using comprehensive MD simulations and hybrid QM/MM calculations we address, herein, the origin of promiscuity in P450 GcoA and its relevance to the specific activity toward lignin-derived substrates. Our study shows a crucial role of an aromatic dyad, F169, and F395 through regulating the water access to the catalytic center. The F169A mutation opens a water aqueduct and hence increases the native activity for the G-lignin. We show that syringol binds very tightly in the WT enzyme which blocks the conformational rearrangement needed for the second step of O-demethylation. The F169A creates an extra room favoring the conformational rearrangement in the demethylated syringol (3MC) and second dose of the dioxygen insertion. Therefore, using MD simulations and complemented by thorough QM/MM calculations, our study shows how does a single site mutation re-architect active site engineering for promiscuous syringol activity.
Radiolysis-Driven Evolution of Gold Nanostructures – Model Verification by Scale Bridging in situ Liquid-Phase Transmission Electron Microscopy and X-ray Diffraction
Authors: Fritsch Birk , Zech Tobias Sebastian , Bruns Mark Peter , Körner Andreas , Khadivianazar Saba , Wu Mingjian , Zargar Talebi Neda , Virtanen Sannakaisa , Unruh Tobias , Jank Michael Peter Max , Spiecker Erdmann , Hutzler Andreas
Published: April 2022

Formation and degradation of gold nanostructures in tetrachloroauric acid (HAuCl4) is comprehensively investigated via in situ liquid-phase transmission electron microscopy (LP-TEM). By introducing a novel technique to simulate arbitrary kinetic models for radiochemistry, we provide a holistic understanding of reaction mechanisms in irradiated HAuCl4 solutions, allowing for quantitative prediction and tailoring of redox processes in LP-TEM experiments. It is demonstrated that no experimentally relevant threshold for gold reduction during LP-TEM exists and that radiation-induced metal-ion reduction is relevant even for experiments utilizing X-rays such as X-ray diffraction (XRD). Furthermore, we unveil that oxidative etching of gold nanoparticles depends on both, precursor concentration, and dose rate. This dependency is harnessed to probe the electron beam-induced shift in the Gibbs free energy landscape by analyzing the critical radius of gold nanoparticles.
DNA-Origami surface patterning through polymer conjugation
Authors: Alleva Nico , Winterwerber Pia , Whitfield Colette J. , Ng David , Weil Tanja
Published: April 2022

The combination of DNA-origami and synthetic polymers paves the way to a new class of structurally precise biohybrid nanomaterials for diverse applications. Herein, we introduce the grafting to method with high conversions (70-90%) under ambient conditions to generate DNA-polymer conjugates, which can hybridized precisely to DNA-origami architectures. We generated homo and block copolymers from three different polymer families (acrylates, methacrylates and acrylamides), coupled them to single stranded DNA (ssDNA) and pattern different DNA-origami architectures to demonstrate the formation of precise surface nanopatterns.
Catalan solids from superionic nanoparticles
Authors: Bian Tong , Lobato Ivan , Wang Ji , Nitka Tara A. , Peled Tzuf Shay , Lee Byeongdu , Van Aert Sandra , Bals Sara , Vuković Lela , Altantzis Thomas , Král Petr , Klajn Rafal
Published: April 2022

The self-assembly of inorganic nanoparticles (NPs) into ordered structures (superlattices) has led to a wide range of nanomaterials with unique optical, magnetic, electronic, and catalytic properties. Various interactions have been employed to direct the crystallization of NPs, including van der Waals forces, hydrogen bonding, as well as electric and magnetic dipolar interactions. Among them, Coulombic interactions—ubiquitous in nature and the main driving force behind the formation of many minerals, such as fluorite or rock salt—have remained largely underexplored, owing to the rapid charge exchange between NPs bearing high densities of opposite charges (superionic NPs). Here, we worked with superionic NPs under conditions (room temperature, concentrated salt solutions) that preserved their native surface charge density. We demonstrate that under these conditions, the Coulombic interactions between superionic NPs are reminiscent of short-range intermolecular interactions. Our methodology was used to assemble oppositely charged NPs into high-quality superlattices exhibiting Catalan shapes. Depending on their size ratio, the NPs assembled into either rhombic dodecahedra or triakis tetrahedra with structures mimicking those of the ionic solids CsCl and Th3P4, respectively. We envision that the methodology described here can be applied to a wide range of charged NPs of various sizes, shapes, and compositions, thus facilitating the discovery of new nanomaterials.
Tripeptide-assisted gold nanocluster formation for sensing Fe3+ and Cu2+
Authors: Youn Jonghae , Kang Peiyuan , Crowe Justin , Thornsbury Caleb , Kim Peter , Qin Zhenpeng , Lee Jiyong
Published: April 2022

Over the past decade, various fluorescent gold nanoclusters (AuNCs) have been studied for their potential as metal ion sensors. Due to the importance of the surface ligand in stabilizing nanocluster and sensing target metal ions, there is a great need of further investigations into possible surface ligands to develop selective and sensitive sensors. In this study, we designed very simple tripeptides to form fluorescent AuNCs by taking advantage of the reduction capability of tyrosine under alkaline conditions. In addition to studying the role of tyrosine in forming AuNC, we also investigated the role of tyrosine in sensing metal ions. Two tripeptides, tyrosine-cysteine-tyrosine (YCY) and serine-cysteine-tyrosine (SCY), were prepared and used for the formation of AuNCs. We obtained AuNCs with blue and red fluorescence from YCY peptides and AuNCs with blue fluorescence from SCY peptides. We found that the fluorescence of blue fluorescence-emitting YCY- and SCY-AuNCs is selectively quenched with Fe3+ and Cu2+, while the fluorescence of the red fluorescence-emitting YCY-AuNC is stable with 13 different metal ions. We have observed that the number of tyrosine residues affects the response of sensors. In the presence of different metal ions, different aggregation propensities were observed from DLS measurement. These results suggest the chelation between the peptide on the AuNC surface and the target ions results in aggregation and causes fluorescence quenching. Our study has shown that very simple and short peptides can be designed rationally for the formation of fluorescent AuNCs and utilized as the surface ligand for the metal ion sensing.
Research Progress on the Pharmacological Effects and Quality Analysis Methods of Bupleurum
Authors: Zhang Kai , Zheng Xianling , Zhang Hongfeng , Zhang Xueqiang , Xu Yanmin , Jin Shiying , Huo Shuang
Published: April 2022

Bupleurum has been used as traditional medicine in China, Japan, South Korea, and other Asian countries for more than 2,000 years. The crude extracts and pure compounds isolated from Bupleurum have a variety of biological activities, such as anti-inflammatory, anti-cancer, antipyretic, antibacterial, anti-viral, liver protection, neuroprotection, and immune regulation. The pharmacological effects of Bupleurum have been classified and summarized in this paper by consulting literatures at home and abroad. At the same time, the quality analysis methods of bupleurum, including high-performance liquid chromatography, thin layer chromatography, ultra-high-performance liquid chromatography mass spectrometry, UPLC-QTOF-MS, and so on, are discussed. This paper provides a reference for further research, development, and application of Bupleurum.
Faktor-Faktor Yang Mempengaruhi Kualitas Prosedur Pengendalian Internal Dan Perannya Dalam Memoderasi Hubungan Persepsi Keadilan Organisasi Terhadap Employee Fraud
Authors: Hariyanti Ika
Published: April 2022

This research aims to analyze the perception of organizational justice on employeefraud moderated by the quality of the internal control procedures of manufacturecompany in Semarang. The factors which affect the quality of internal controlprocedures is ethical corporate environment, risk management training, internalaudit activities, suitability compensation and power leadership. The population ofthis research is the top management level at the manufacture company in Semarang.The sampling technique is random sampling. 32 samples used in this research andOLS regression analysis with SPSS 19 version program. The results of this researchverify that quality of internal control procedures positively moderate the relationbetween perception of organizational justice and employee fraud. Ethical corporateenvironment and risk management training has a positive and not significant to thequality of internal control procedures. Internal audit activities has positive andsignificant to the quality of internal control procedures. Suitability compensationand power leadership has a negative and significant to the quality of interna controlprocedures.
Pengaruh Return on Equity, Current Ratio, Size Company dan Debt to Equity Ratio Terhadap Nilai Perusahaan
Authors: Listyawati Ika , Kristiana Ida
Published: April 2022

Firm value is a factor that investors consider in making investment decisions. This study examines the effect of profitability, liquidity, company size and capital structure on firm value in manufacturing companies listed on the Indonesia Stock Exchange in 2014 - 2018.The sample used in this study consists of 34 manufacturing companies listed on the Indonesia Stock Exchange in 2014. 2014 - 2018. The sample was taken by using purposive sampling method.The variables used are Price Book Value (PBV), Return on Equity (ROE), Current Ratio (CR), Total Asset (Size) and Debt to Equity Ratio (DER). The population is all manufacturing companies listed on the Indonesia Stock Exchange as many as 34 companies during 2014-2018. The results showed that Return on Equity (ROE) had a positive and significant effect on Price Book Value (PBV), Current Ratio (CR) had a positive and significant effect on Price Book Value (PBV), Firm Size had a positive and significant effect on Price Book Value ( PBV), Dept on Equity Ratio (DER) have a negative and significant effect on Price Book Value (PBV).
Kepatuhan Wajib Pajak Membayar PBB: Studi Empiris Kecamatan Arut Selatan
Authors: Ningtias Puji Larasati , Wibowo Raden Ery , Alwiyah Alwiyah , Sukesti Fatmasari , Hanum Ayu Noviani
Published: April 2022

This purpose of this study to determine and analyze the effect of tax socialization, income levels, service quality, and tax enforcement on the level of taxpayer compliance in paying land and building tax in South Arut District. The samples used in this study were 100 land and building taxpayers who were in South Arut District. The independent variables used in this study were Tax Socialization, Income Level, Service Quality, and Tax Knowledge. While the dependent variable is Taxpayer Compliance. This study uses a quantitative analysis method that describes the state of the variables under study using statistical data. All indicators of this study must first pass the validity and reliability of the data, then test the classical assumptions and finally test the hypothesis. The results showed that: Tax Socialization, Income Level, Service Quality, and Tax Knowledge partially and simultaneously had a significant positive effect on taxpayer compliance in Arut Selatan District with a significance level of 0.002 <0.05. The value of Adjusted R2 showed that 86% of land and building taxpayer compliance is influenced by independent variables, while the remaining 14% is influenced by other variables outside of this study.Kepatuhan Wajib Pajak Membayar PBB: Studi Empiris Kecamatan Arut Selatan
Faktor-Faktor yang Mempengaruhi Return Saham: Studi Industri Barang Konsumsi yang Listing di BEI
Authors: Solechah Umi , Hanum Ayu Noviani , Alwiyah Alwiyah , Hardiwinoto Hardiwinoto , Wibowo Raden Ery
Published: April 2022

This research to analyze the influence of Current Ratio, Debt to Equity Ratio and Return On Asset simultaneously and partially to stock return of manufacturing company sectors of Consumer Goods Industry listed on Indonesia Stock Exchange (IDX) period 2015-2019. Sampling in this research uses the purposive sampling method. The population in this research is a manufacturing company sectors of Consumer Goods Industry listed on the Indonesia Stock Exchange (IDX) period 2015-2019. Total population of 53 companies and companies that meet the criteria as a sample as many as 23 companies. The period of observation in this research for 5. years from 2015-2019. The analytical techniques used are multiple regression analyses. The results showed that Return On Assets (ROA) have a partially effect that is positive and significant to stock return. The Current Ratio (CR) and Debt to Equity Ratio (DER) have a partially effect that is negative and significant to stock return. While simultaneously the Current Ratio (CR), Debt to Equity Ratio (DER), and Return On Assets (ROA) influence the stock return. The result of determination coefficient (R2) showed that Current Ratio (CR), Debt To Equity Ratio (DER), and Return On Assets (ROA) in explaining the stock return was 33,6 % and the rest was explained by other unexamined variable in this research.
PENGEMBANGAN BAHAN AJAR BERBASIS MULTIMEDIA INTERAKTIF PADA MATA KULIAH PENDIDIKAN SENI MUSIK DI PROGRAM STUDI PENDIDIKAN GURU SEKOLAH DASAR STKIP PGRI LUBUKLINGGAU
Authors: Batubara Abi Karoma , Firduansyah Dedy
Published: April 2022

Permasalahan dalam penelitian ini adalah bagaimanakah pengembangan bahan ajar berbasis multimedia interaktif pada mata kuliah pendidikan seni musik di Program Studi Pendidikan Guru Sekolah Dasar STKIP PGRI Lubuklinggau? Tujuan dalam penelitian ini yaitu untuk membuat sebuah produk media pembelajaran dalam bentuk Software bagi mahasiswa di Program Studi Pendidikan Guru Sekolah Dasar STKIP PGRI Lubuklinggau. Sementara metode yang digunakan dalam penelitian ini adalah research and development. Model yang digunakan adalah model Rowntree dikarenakan berorientasi pada produk, khususnya untuk memproduksi media pembelajaran berupa multimedia interaktif. Model pengembangan ini terdiri dari tiga tahap, yaitu: a) Perencanaan (Planning); b) Pengembangan (Development); c) Evaluasi (Evaluation). Adapun teknik pengambilan data mengunakan wawancara, angket, dan tes, teknik analisis data mengunakan skala likert. Hasil penelitian menunjukan validasi bahasa tergolong dengan kategori diperoleh nilai rata-rata 4,5 yang berarti cukup valid. Hasil validasi materi oleh ahli materi diperoleh nilai rata- rata 4,5 dengan kriteria sangat valid. Ahli media di atas diperoleh nilai rata-rata 4,5 dengan kriteria sangat valid, dan pada tes kelompok kecil didapatkan nilai 81,11. Secara keseluruhan hasil dari analisis dan perhitungan nilai angket dari tim ahli dan test kelompok kecil, bahan ajar berbasis multimedia interaktif pada Matakuliah Pendidikan Seni Musik di Program Studi Pendidikan Guru Sekolah Dasar STKIP PGRI Lubuklinggau dapat dikatakan valid praktis.
Islam, Culture, and Social Media: A Study on the Culture of the Social Media Usage in the Covid-19 Pandemic Era
Authors: Huda Moh. , Nur Iffatin
Published: April 2022

The Covid-19 pandemic has brought various significant impacts on the cultural shift in the society, one of which is the culture of using social media. This is based on the fact that in the Covid-19 pandemic situation there has been a very significant cultural shift in the use of social media, so that in practice, social media culture in the Covid-19 pandemic era has various impacts, both positive and negative impacts. With these various problems, this study aims to look at social media culture in the era of the Covid-19 pandemic from an Islamic perspective. As an effort to answer the problems above, this study uses a literature review with data sources from books, journal articles, and various online newspapers with data analysis methods using content analysis. The findings in this study indicate that the culture of society in the use of social media in the era of the Covid-19 pandemic has experienced a very significant increase. This increase in the view of Islam is supported when humans explore the ability to increase their knowledge and abilities in their fields. On the other hand, if the increasing culture of social media in the era of the Covid-19 pandemic leads people to a crime, then Islam has the consequence of giving a ban.
Case-Based Instruction in the Forensic Chemistry Classroom: Effects on Students' Motivation and Achievement
Authors: Magwilang Epiphania B.
Published: April 2022

Forensic chemistry students need to be motivated and develop critical thinking, problem-solving, and higher-order thinking skills and not just accumulate many facts to be good evidence collectors and investigators in the future. As case-based instruction has been utilized in various fields to this effect, this study aimed to determine the effects of such a method on students' motivation towards forensic chemistry learning and their success in understanding the taught concepts through their achievement scores. A pre-test post-test control group design was employed to involve two forensic chemistry classes with 42 students each, identified through the purposive sampling technique. One class was taught through case-based instruction, while the other through the lecture method. The classes were assigned to experimental and control groups to examine the study's treatment process effects through a coin toss. The t-test for independent samples was used to determine significant differences in students' pre/post-test scores in the treatment and the control group for the motivation and achievement tests. The two groups of respondents exhibited increased motivation and achievement mean scores with significant differences. However, those exposed to case-based instruction had higher mean scores than those taught with the lecture method. Thus, the use of case-based instruction in the forensic chemistry classroom promotes critical thinking, problem-solving, and higher-order thinking skills leading to significant positive changes in the motivation and achievement of students in the course. Therefore, case-based education is recommended as it is expected to make positive contributions to the forensic chemistry teaching process and science education.
An Empirical Model for Backscattering Coefficients of Vegetation Fields at 5.4 GHz
Authors: Oh Yisok , Chang Jisung Geba , Shoshany Maxim
Published: April 2022

A new, simple empirical model for microwave backscattering from vegetation fields at 5.4 GHz is proposed in this paper. First, a modified radiative transfer model (RTM) is used to generate a database of multi-polarized backscattering coefficients of various vegetation fields at 5.4 GHz with wide ranges of vegetation biomasses and soil moistures. Second, we propose a functional form of an empirical model that is a simplified water cloud model (WCM) after closely examining the behaviors of the well-known WCM based on an extensive database that includes the modified RTM outputs, scatterometer measurements, SAR datasets, and in situ measured ground-truth data for various vegetation fields. Finally, the unknown constant parameters of the empirical model are determined for each soil moisture condition based on the extensive database. The new empirical model is verified with the database itself, and also with independent Sentinel-1 synthetic aperture radar (SAR) data and in situ measured ground-truth data.
Analisis Unsur Sosial dan Konflik Sosial dalam Cerkak “Anak Lanang” Karya Dyand D. (Kajian Sosiologi Sastra)
Authors: Rahmawati Rizka Auliya , Sulanjari Bambang
Published: April 2022

Penelitian ini bertujuan untuk mendeskripsikan unsur sosial serta konflik sosial cerkak “Anak Lanang” karya Dyand D. Metode yang digunakan pada penelitian ini adalah metode deskriptif kualitatif. Sumber data dalam penelitian ini berupa cerkak dari Majalah Jayabaya, minggu IV September 2020. Data dalam penelitian ini berupa sinopsis serta kutipan kalimat pada cerkak yang mengandung permasalahan sosial yang terdapat dalam cerkak “Anak Lanang” karya Dyand D. Adapun teknik pengumpulan data meliputi membaca cerkak “Anak Lanang” secara intensif, lalu menganalisis unsur sosial dan konflik sosial dalam cerkak dan mendeskripsikannya. Metode ini merupakan suatu proses pengumpulan data untuk mendeskripsikan mengenai unsur-unsur sosial serta konflik sosial dalam cerkak “Anak Lanang” karya Dyand D menggunakan pendekatan teori sosiologi sastra. Unsur sosial yang terdapat dalam cerkak meliputi unsur sosial kebudayaan, pendidikan, religi dan moral. Konflik sosial dalam cerkak ini ditunjukkan ketika tokoh Nanang bertanya kepada Ami mengenai ia anak kandung Ami atau bukan, dan ditunjukan bahwa Nanang bukanlah anak kandung dari Ami. Setelah melalui proses penelitian analisis sosiologi sastra berupa unsur sosial serta konflik sosial yang terdapat pada cerkak, terlihat upaya pengarang yang memadukan unsur serta konflik sosial dengan baik, sehingga makna serta pesan yang terkandung dalam cerkak bisa sampai pada pembaca.Kata kunci: Analisis Sosiologi sastra, Cerkak, Karya Sastra, Konflik Sosial, Anak Lanang.
Hybrid imperative forms in Polish: Problems of translations into German and English
Authors: Grunwald Jadwiga
Published: April 2022

The article deals with the grammatical constructions expressing the imperative in Polish with particular focus on the variations used in spoken language. Colloquial Polish often uses structures which could be described as verb + pan/pani! They can be used for any perfective as well as imperfective verb. One of the most popular phrases according to this pattern is the phrase daj pan/pani spokój! Phrasemes of this type are used mostly in slang and are characterised by brevity. The research material consists of two different databases: the National Corpus of Polish as well as the online translator Reverso Context. The article presents a number of difficulties experienced by German and English translators. It also shows why the process of translation is a balancing act between remaining true to the original content on the one hand, and creating a translation complying the requirements of the medium for which the translation is being made, on the other hand.
Establishment of criteria for gamma-analysis of individual dose distributions during verification of radiotherapy high-tech treatment plans for cancer patients
Authors: Piatkevich M. N. , Brynkevich H. I. , Titovich E. V.
Published: April 2022

A typical process for verification of treatment plans in intensity-modulated radiation therapy is described. The main errors and uncertainties that arise in the course of planning dose distribution and in the process of dose delivery are listed. Methods for comparing dose distributions are considered: the distance to agreement (DTA) and the test for the algebraic dose difference. Formulas for calculating the shift of points of dose distributions, as well as the minimum value of the shift of points, are provided. The influences of global and local normalization and spatial resolution on the interpretation of the results obtained are defined. A methodology for determining reasonable criteria for gamma-analysis of individual dose distributions when verifying plans for irradiation of cancer patients using high-tech radiation therapy methods has been developed. Using the procedure proposed by the authors to establish action limits and tolerances will make it possible to assess the quality of medical care provided in healthcare institutions when using high-tech radiotherapy methods
Experimental Autoimmune Encephalomyelitis Animal Models Induced by Different Myelin Antigens Exhibit Differential Pharmacologic Responses to Anti-Inflammatory Drugs
Authors: Yan Yuxi , Zhao Quan , Huang Ya , Yang Janine Y. , Zou Jie , Ao Chunxia , Chai Xiaojuan , Tang Renhong , Yang WenQing
Published: April 2022

Background and objective Experimental autoimmune encephalomyelitis (EAE) is the most commonly used model for studying autoimmune-mediated myelin degradation in multiple sclerosis (MS). Here, we evaluated the pharmacologic responses of several anti-inflammatory drugs with varying mechanisms of actions (MOAs) using EAE models induced by different MOG immunogens to reveal differential pharmacologic characteristics of the disease models and provide a general guidance in animal model selection for MS research. Methods The pharmacologic responses of anti-inflammatory drugs with different mechanisms of actions (MOAs) were evaluated using EAE models induced by either myelin oligodendrocyte glycoprotein p35-55 ï¼MOG35-55ï¼or p1-128 (MOG1-128). EAE animal models were developed in mice with C57BL/6 background. The animals were treated with different anti-MS medications, including 3 B cell-mediated agents and 2 T cell-mediated agents, respectively. Clinical symptoms were monitored and scored, and pharmacodynamic markers including cytokine secretion, inflammatory cell infiltration, and demyelination in spinal cord were analyzed. Results In MOG35-55 peptide-induced EAE model, T cell modulating agents Secukinumab and Fingolimod significantly alleviated clinical symptoms, while B cell-depleting agents, BTK inhibitors PRN2246 and Telitacicept, displayed minimal therapeutic effects or even exacerbated disease progression. In contrast, both T cell-modulating agents and B cell-depleting agents ameliorated disease severity in MOG1-128-induced EAE model. T cell and B cell infiltration in spinal cord increased with disease progression in MOG1-128-induced EAE model. Conclusions Our results demonstrated that induction of EAE by different myelin antigens resulted in differential pharmacologic responses to drugs with specific MOAs. The MOG35-55 peptide-induced EAE model only responded to T cell-modulating drugs, whereas the MOG1-128 protein-induced EAE model exhibited therapeutic sensitivity to both T cell- and B cell-modulating agents. These data suggest the MOG35-55 peptide-induced EAE model is suitable for assessing T cell-modulating agents while MOG1-128 protein-induced model can be employed to evaluate both T cell- and B cell-modulating agents.
Hubungan Faktor Internal Dan Eksternal Akseptor Terhadap Kepatuhan Akseptor Kontrasepsi Suntik
Authors: Oktaviana Khofifah Dwi , Anas Muhammad , Ariningtyas Ninuk Dwi , Marlina Uning
Published: April 2022

The population of Indonesian continues to increase, while the total fertility rate is not yet on target. So that an effective family planning program is needed to reduce Indonesia's population growth. Injection contraceptive acceptor adherence is needed to maximize family planning programs for a better future. Objective: to analyze the relationship between age, education, knowledge, work status, and support from husbands of injection contraceptive acceptors in women of childbearing age to compliance with re-injection visits. The study was using an analytical observational, cross-sectional study design. The sampling technique was non-random sampling purposive sampling, a sample size of 96 people, a questionnaire was used to collect data and data analysis using the chi-square test. Results: The number of adherent injecting contraceptive acceptors was 57.3%. The results showed that the variables associated with injection visit compliance were age (p = 0.022), knowledge (p = 0.005), and work status (p = 0.017). Meanwhile, the variables not related to compliance with injection visits were education (p = 0.172), husband's support (p = 0.833) and the number of children (p=0.167). Conclusion: There is a relationship between age, knowledge, and work status on the compliance of injection contraceptive acceptor visits.  Jumlah penduduk indonesia terus mengalami peningkatan, sedangkan total fertility rate belum sesuai target. Sehingga diperlukan program keluarga berencana yang efektif untuk menurunkan pertumbuhan penduduk indonesia. kepatuhan akseptor kontrasepsi suntik sangat diperlukan untuk memaksimalkan program keluarga berencana demi masa depan yang lebih baik. Tujuan : menganalisis hubungan usia, pendidikan, pengetahuan, status bekerja, dan dukungan suami akseptor kontrasepsi suntik pada wanita usia subur terhadap kepatuhan melakukan kunjungan suntik ulang. Jenis penelitian yang digunakan dalam penelitian ini yaitu analitik observasional desain Cross-sectional study. Teknik samplingnya menggunakan  non random sampling - purposive sampling, besar sampel 96 orang, kuesioner digunakan untuk mengumpulkan data dan analisis data menggunakan uji chii square. Hasil: Jumlah akseptor kontrasepsi suntik yang patuh yaitu sebesar 57,3%. Hasil penelitian diperoleh bahwa variabel yang berhubungan dengan kepatuhan kunjungan suntik yaitu usia (p=0,022), pengetahuan (p=0,005), dan status bekerja (p=0,017). Sedangkan variabel yang tidak berhubungan dengan kepatuhan kunjungan suntik yaitu pendidikan (p=0,172), dukungan suami (p=0,833), dan jumlah anak (p=0,167). Kesimpulan: Terdapat hubungan antara usia, pengetahuan, dan status bekerja terhadap kepatuhan kunjungan akseptor kontrasepsi suntik.
Use of Literature, Resources and Innovative Methodologies in the English Classroom
Authors: Torrano Guillamón Lorena , Cascales Martínez Antonia , Carrillo García María Encarnación
Published: April 2022

This research is aimed at analysing English teachers’ perception, use and level of professional development regarding literature, resources and innovative methodologies in the classroom. The type of quantitative investigation method used had a descriptive-com-parative nature, where 70 secondary teachers, that taught English as a foreign language, answered a questionnaire created ad hoc. The results show that teachers consider literature as a great resource for the development of basic competences; nevertheless, most of them do not use it to a great extent and, when they do, it is through reading tasks of textbooks and graded books. We conclude that literature texts are perceived as too difficult, probably because teachers may not know how to select the best-suited works in terms of cognition and interest. As educational implications, we propose for EFL teachers to acquire, during their initial education, the pertinent knowledge about literary works, tasks, ICTs and audiovisual materials for the teaching of English, and how to assess these contents. It is interesting, to point out the limitations of the study, related to the compilation of the best literature works for the English teaching, in order to plan future lines of investigation.
Telecolaboración y competencia comunicativa intercultural en la enseñanza-aprendizaje de ELE: un proyecto en educación superior
Authors: Villegas Paredes Gladys , Canto Gutiérrez Silvia , Rodríguez Moranta Inmaculada
Published: April 2022

Este artículo evalúa los resultados de un proyecto telecolaborativo en educación superior mediante el análisis de las percepciones sobre la competencia comunicativa intercultural (CCI) de los participantes, aprendices de español como lengua extranjera (ELE) y profesorado en formación (PF) de dos universidades diferentes. El intercambio virtual se realizó mediante video comunicación con cinco tareas colaborativas durante el primer cuatrimestre del curso 2020-2021. La metodología corresponde a la investigación-acción, siendo un estudio descriptivo e inferencial de tipo correlacional. Se recogieron evidencias mediante cuestionarios para conocer y valorar si los participantes habían percibido mejoras en su CCI tras la intervención, empleando estadísticos de correlación adecuados al nivel de medida de las variables para determinar el grado de relación y el nivel de significatividad entre las opiniones de los participantes antes y después de la experiencia telecolaborativa. Los resultados sugieren que después de la telecolaboración los aprendices de ELE muestran opiniones favorables sobre su competencia intercultural al interactuar con hablantes nativos de la lengua meta y el profesorado en formación percibe mejoras en sus conocimientos culturales, sus habilidades y actitudes interculturales.
Exploring Audiovisual translation as a didactic tool in the Secondary school foreign language classroom
Authors: Bobadilla-Pérez María , Carballo de Santiago Ramón Jesús
Published: April 2022

The aim of this research is to showcase the versatility of Audiovisual Translation (AVT) as a resource in the language classroom. Didactic AVT helps students improve their communicative competence and linguistic skills in the foreign language (L2). Students also develop their digital competence by working with online resources and AVT editing software, and their intercultural competence by being exposed to authentic material in their L2. Mediation skills, as promoted by the CEFR (2001), are also developed with the implementation of didactic AVT. The literary review first introduces general concepts of didactic AVT, and later breaks down different AVT modes to focus on the benefits and potential downsides as classroom resources inherent to each one: subtitling, dubbing, subtitling for the deaf and hard of hearing (SDH) audio description (AD), and creative AVT.  With the intention of exemplifying some practical applications of AVT modes as central tasks in Secondary school EFL classrooms, this paper presents four learning sequences which are based on the theoretical principles reported in the reviewed literature. These learning sequences are not meant to be prescriptive, but rather an example of  potential ways to implement AVT in the classroom.
Autoestima en estudiantes españoles de secundaria: dimensiones e influencia de variables personales y educativas
Authors: Frieiro Paula , González-Rodríguez Rubén , Domínguez Alonso José
Published: April 2022

El interés de la autoestima durante la adolescencia es fundamental, ya que promover una autoestima positiva y reducir el impacto de la autoestima negativa, posibilita el desarrollo óptimo de gran parte de las experiencias escolares, personales y de bienestar general. El presente estudio tuvo como objetivo evaluar las evidencias de validez y fiabilidad de la Escala de Autoestima (Rosenberg Self-Esteem Scale) en estudiantes españoles y comprobar si el género, la edad, el curso académico y el tipo de centro son determinantes para su desarrollo. Participaron un total de 698 estudiantes de Educación Secundaria Obligatoria (ESO) que se agruparon en dos muestras aleatorias (muestra 1: 364 alumnos, M=12.57; DT= .49 y muestra 2: 334 alumnos, M=14.62; DT= .48). Los resultados identificaron una estructura factorial de dos factores (autoestima positiva y autoestima negativa) (χ2/gl= 2.938; CFI= .948; NNFI= .924; SRMR = .045; RMSEA= .075), con una consistencia interna elevada (α = .853). Asimismo, los análisis de multivarianza mostraron que los adolescentes presentan una mayor autoestima positiva si son de género masculino, cursan primero, segundo o tercero de ESO y estudian en centros concertados, mientras que exhiben una alta autoestima negativa los adolescentes de género masculino que cursan primero de ESO con edades inferiores a los 13 años. La escala Rosenberg ha demostrado tener propiedades psicométricas adecuadas para ser utilizada en estudiantes de educación secundaria de España.
PENGARUH PROFIL GURU TERHADAP MINAT BELAJAR SISWA
Authors: Lase Berkat Persada
Published: April 2022

Penelitian ini bertujuan untuk mengetahui pengaruh profil guru terhadap minat belajar siswa. Penelitian ini menggunakan desain deskriptif dengan metode kuantitatif. Penelitian ini dilaksanakan di SMA Negeri 1 Gunungsitoli dan jumlah siswa kelas XI adalah 25 siswa. Berdasarkan uji validitas variabel (x) diperoleh rhitung (0,752) > rtabel (0,396) hasilnya valid dan variabel (y) mendapat rhitung (0,669) > rtabel (0,396) hasilnya valid, berdasarkan variabel uji reliabilitas (x) diperoleh rhitung (0,785) > rtabel (0,396) dan hasil reliabilitas variabel (y) diperoleh rhitung (0,836 >rtabel (0,396) hasil reliabel, berdasarkan hasil uji koefisien determinasi, selanjutnya diperoleh hasil 95% diperoleh berdasarkan korelasi data instrumen penelitian maka diperoleh rhitung = 0,831 > rtabel 0,396 dikategorikan tinggi. Hasil uji hipotesis atau uji t diketahui bahwa nilai dk = n-2 (25-2=23) dengan keyakinan taraf 0,05% yaitu thitung (3,304) > ttabel (1,714).
PENINGKATAN AKTIVITAS DAN HASIL BELAJAR PESERTA DIDIK MELALUI METODE BERNYANYI DALAM MENGENAL MALAIKAT DAN TUGASNYA PADA PENDIDIKAN AGAMA ISLAM DI KELAS IV SDN 46 TUANKU AMIR
Authors: Yasir Zuhudiyah
Published: April 2022

Penelitian ini bertujuan untuk mendeskripsikan peningkatan aktivitas dan hasil belajar peserta didik melalui metode bernyanyi dalam mengenal malaikat dan tugasnya pada pembelajaran Pendidikan Agama Islam di Kelas IV di SDN 46 Tuanku Amir. Penelitian menggunakan pendekatan kualitatif dan kuantitatif. Prosedur penelitian terdiri dari: tahap perencanaan, pelaksanaan, pengamatan, dan refleksi. Data penelitian diperoleh melalui tes kognitif, afektif, dan psikomotor, serta menggunakan lembaran observasi. Hasil penelitian menunjukan bahwa aktivitas belajar peserta didik melalui metode bernyanyi dalam mengenal malaikat dan tugasnya terjadi peningkatan dengan ketuntasan pada Siklus I adalah 79%, setelah direfleksi meningkat menjadi 97% pada siklus II. Peningkatan hasil belajar peserta didik sangat baik dan meningkat. Terbukti pada siklus I ketuntasan peserta didik mencapai 72%, setelah direfleksi terjadi peningkatan sebesar 97%. Penelitian ini menghasilkan kesimpulan adanya peningkatan aktivitas dan hasil belajar peserta didik melalui metode bernyanyi dalam mengenal malaikat dan tugasnya pada pembelajaran Pendidikan Agama Islam di kelas IV SDN 46 Tuanku Amir.
RANCANG BANGUN SISTEM MONITORING DAN KONTROL JEMURAN PAKAIAN BERBASIS IOT
Authors: Milandika Risnadona Putra , Nugroho Widhi Bagus , Yudantoro Tri Raharjo , Sulistiyo Wahyu , Wiktasari Wiktasari
Published: April 2022

Dalam kehidupan sehari-hari, manusia pasti akan melakukan kegiatan kebersihan mulai dari hal kecil seperti membersihakan diri sendiri hingga hal besar seperti membersihkan rumah. Salah satu kegiatan kebersihan yang dilakukan hampir setiap hari oleh manusia di setiap rumah tangga adalah membersihkan pakaian dengan cara mencuci hingga bersih lalu menjemurnya supaya kering. Meski dilakukan hampir setiap hari, membersihkan pakain bukan berarti tidak memiliki kendala. Karena kegiatan ini sering dilakukan oleh orang-orang di usia produktif  dan sibuk dengan kegiatan mereka sehingga mereka lupa untuk memonitor pakaian yang dijemur. Jika terjadi hujan pakaian yang sudah dicuci dan dijemur dan tidak segera di angkat atau diteduhkan maka akan basah kembali, sehingga harus dicuci ulang yang berarti membutuhkan waktu dan tenaga lebih untuk membersihkan pakaian kembali. Selain itu, di usia produktif ini, tak jarang orang-orang yang pilangnya terlambat hingga larut malam karena kesibukannya dan tidak bisa mengangkat jemurannya ketika sudah sore hari dan pakaian masi di luar ruangan dapat mengakibatkan pakaian lembab dan bau apek dan harus dicuci kembali. Untuk memudahkan mengontrol dan memonitor pakaian yang dijemur, diperlukan sebuah alat yang dapat meneduhkan pakaian yang dijemur secara otomatis jika terjadi hujan. Alat ini menggunakan beberapa sensor yang dapat membantu memonitor status jemuran. Menggunakan sensor hujan untuk mendeteksi hujan sehingga dapat melakukan aksi yaitu berupa meneduhkan jemuran supaya tidak kehujanan dan sensor cahaya (LDR) untuk mendeteksi cahaya matahari, ketika cahaya matahari redup yang diakibatkan mendung atau sore hari, alat dapat melakukan aksi meneduhkan jemuran supaya tidak lembab dan harus dicuci ulang kembali.
ANALISIS KESALAHAN BERBAHASA TATARAN SINTAKSIS PADA SURAT EDARAN UNIVERSITAS SEBELAS MARET SEMESTER GENAP TAHUN AJARAN 20202021
Authors: Sari Efa Yunita , Agustine Gifta Silvia , Qurniyawati Rizqi , Ulya Chafit
Published: April 2022

Penelitian ini berjudul “Analisis Kesalahan Berbahasa Tataran Sintaksis pada Surat Edaran Universitas Sebelas Maret Semester Genap Tahun Ajaran 2020/2021”. Tujuan dari penelitian ini untuk menganalisis kesalahan berbahasa tataran sintaksis dan pembetulannya pada surat edaran Universitas Sebelas Maret semester genap tahun ajaran 2020/2021 serta mengetahui pentingnya penggunaan kalimat efektif dalam komunikasi tulis dan lisan. Metode yang digunakan deskriptif kualitatif. Data yang digunakan dalam penelitian ini adalah Surat Edaran Universitas Sebelas Maret Semester Genap Tahun Ajaran 2020/2021. Teknik analisis data menggunakan reduksi data, sajian data, dan penarikan kesimpulan. Langkah-langkah penelitian meliputi mengumpulkan data, mengidentifikasi kesalahan, mengklasifikasi kesalahan, dan mengevaluasi kesalahan bahasa. Hasil penelitian menunjukkan terdapat 13 kesalahan penggunaan kalimat efektif. Kesalahan-kesalahan tersebut meliputi 2 kesalahan pada bentuk kelugasan, 4 kesalahan pada bentuk kejelasan, 4 kesalahan pada bentuk ketepatan, 1 kesalahan pada bentuk kehematan, 1 kesalahan pada bentuk kesejajaran, dan 1 kesalahan pada bentuk kelogisan.