bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of Dietary Fish Meal Replacement with Composite Mixture of Chicken Meal, Krill Meal, and Plant Proteins on Growth, Physiological Metabolism, and Intestinal Microbiota of Chinese Perch (Siniperca chuatsi)
Authors: Ding Liyun , Chen Jiacheng , Zhang Yanping , Xiao Jun , Xu Xiandong , Zhang Haixing , Chen Qingtang , Zhao Yuxiang , Chen Wenjing
Published: December 2023

This trial aimed to investigate the influence of graded replacing fish meal (D1: 0.00%, D2: 27.27%, and D3: 54.55%) with mixed protein ingredients (i.e., chicken meal, krill meal, fermented soybean meal, and soy protein concentrate) on the growth performance, muscle nutritional composition, blood biochemical indices, gut bacterial community, and transcriptome of Chinese perch. Two hundred seventy Chinese perch were divided into three groups (90 per group) and the diet lasted for 56 days. Results showed that the weight gain rate and specific growth rate were significantly lower, and the feed conversion ratio was significantly higher in the D3 group than in fish fed D1 (P<0.05), with no significant differences between the D1 and D2 groups (P>0.05). The muscle crude protein content was highest in the D2 group, and the crude fat content was significantly different in the order: D3 > D1 > D2 (P<0.05). The levels of serum triglycerides (TG) and low-density lipoprotein cholesterol in the D2 group were significantly lower than those in the D1 group (P<0.05), but there was no significant difference compared to the D3 group (P>0.05). The microbial community structure changed significantly. Mycoplasma showed the highest abundance in the D1 and D2 groups (P<0.05), and Cetobacterium peaked in D2 group, and significantly higher than that in D1 group (P<0.05). Network analysis and cohesion index calculation showed that both network complexity and cohesion peaked in D2 group, and Cetobacterium was highly correlated with the cohesion index (P<0.05). Further, muscle transcriptome analysis results showed that compared with the control group, differentially expressed genes were clustered (Q < 0.05) in the arginine and proline metabolism pathways in D2 group. Fish in D3 group significantly (Q < 0.05) affected genes involved in KEGG pathways of ribosome, circadian rhythm, thermogenesis, insulin signaling pathway, fatty acid degradation, oxidative phosphorylation, and apoptosis. In conclusion, under the experimental conditions, the replacement of 27.27% of fish meal by the compound protein did not have a negative impact on the growth performance of Chinese perch and could improve muscle quality, lipid metabolism, and the interaction of intestinal microbiota.
Data from Detection of miR-34a Promoter Methylation in Combination with Elevated Expression of c-Met and β-Catenin Predicts Distant Metastasis of Colon Cancer
Authors: Siemens Helge , Neumann Jens , Jackstadt Rene , Mansmann Ulrich , Horst David , Kirchner Thomas , Hermeking Heiko
Published: December 2023

Abstract
Purpose: Here, we determined whether epigenetic inactivation of miR-34a and miR-34b/c genes may serve as a prognostic marker for distant metastases in colon cancer.

Experimental Design: Using a case–control study design of 94 primary colon cancer samples with and without liver metastases, we determined CpG methylation frequencies of miR-34a and miR-34b/c promoters, expression of miR-34a, and its targets c-Met, Snail, and β-catenin and their prognostic value.

Results:miR-34a methylation was detected in 45.1% (n = 42 of 93) of the samples and strongly associated with metastases to the liver (P = 0.003) and lymph nodes (P = 0.006). miR-34b/c methylation was detected in 91.9% of the samples (n = 79/86). A significant inverse correlation between miR-34a methylation and expression of mature miR-34a (P = 0.018) was detected. Decreased miR-34a expression was associated with upregulation of c-Met, Snail, and β-catenin protein levels (P = 0.031, 0.132, and 0.004), which were associated with distant metastases (P = 0.001, 0.017, and 0.005). In a confounder-adjusted multivariate regression model miR-34a methylation, high c-Met and β-catenin levels provided the most significant prognostic information about metastases to the liver (P = 0.014, 0.031, and 0.058) and matched pairs showed a higher prevalence of these risk factors in the samples with distant spread (P = 0.029). Finally, we obtained statistical evidence indicating that the simultaneous detection of these three markers has the highest prognostic value.

Conclusions: Silencing of miR-34a and upregulation of c-Met, Snail, and β-catenin expression is associated with liver metastases of colon cancer. Detection of miR-34a silencing in resected primary colon cancer may be of prognostic value, especially in combination with detection of c-Met and β-catenin expression. Clin Cancer Res; 19(3); 710–20. ©2012 AACR.
Figure S9 from Discovery of KRB-456, a KRAS G12D Switch-I/II Allosteric Pocket Binder That Inhibits the Growth of Pancreatic Cancer Patient-derived Tumors
Authors: Kazi Aslamuzzaman , Ranjan Alok , Kumar M.V. Vasantha , Agianian Bogos , Garcia Chavez Martin , Vudatha Vignesh , Wang Rui , Vangipurapu Rajanikanth , Chen Liwei , Kennedy Perry , Subramanian Karthikeyan , Quirke Jonathan C.K. , Beato Francisca , Underwood Patrick W. , Fleming Jason B. , Trevino Jose , Hergenrother Paul J. , Gavathiotis Evripidis , Sebti Said M.
Published: December 2023

Treatment of mice with KRB-456 inhibits P-MEK, P-AKT and P-S6 levels and induces apoptosis in KRAS G12D PDXs from pancreatic cancer patients.
Acidodontium indicum (Bryaceae: Bryophyta)—a new species from the Western Ghats of India
Authors: VINEESHA PUTHANPALLIYALIL M. , SAJITHA MENON S. , MANJU CHANDRASEKHARAN N. , SPENCE JOHN R.
Published: December 2023

Acidodontium indicum sp. nov. (Bryaceae), is described and illustrated from the Western Ghats of Kerala. Since the genus has not been reported from India, it represents a new generic record as well. The species is compared with Acidodontium megalocarpum (Hook.) Renauld & Cardot and A. exaltatum (Spruce ex Mitt.) A. Jaeger. Acidodontium indicum is distinguished by small broadly lanceolate to more or less spathulate leaves having a strong, short excurrent costa, margin completely entire, bordered by 1–4 rows of long incrassate cells, short setae, capsule clavate with short apophysis, operculum conic without apiculus and endostome with high basal membrane and forked endostome segments diverging at a different angle.
Parathyroidectomy Improves Bone Density in Women With Primary Hyperparathyroidism and Preoperative Osteopenia
Authors: Frey Samuel , Gérard Maxime , Guillot Pascale , Wargny Matthieu , Bach-Ngohou Kalyane , Bigot-Corbel Edith , Renaud Moreau Nelly , Caillard Cécile , Mirallié Eric , Cariou Bertrand , Blanchard Claire
Published: December 2023

Context

Osteoporosis and/or bone fractures are indications of parathyroidectomy in primary hyperparathyroidism (PHPT), especially in women. However, the benefit of surgery in patients with osteopenia remains unclear.

Objective

To evaluate bone mineral density (BMD) and bone remodeling biomarkers changes 1 year after parathyroidectomy in women with PHPT.

Design

In the prospective, monocentric, observational prospective cohort with primary hyperparathyroidism patients (CoHPT) cohort, women operated for sporadic PHPT since 2016 with ≥1 year follow-up were included. BMD (dual-X ray absorptiometry) and bone remodeling biomarkers [cross-linked C-telopeptide (CTX), procollagen type 1 N-terminal propeptide (P1NP), and bone-specific alkaline phosphatases] were assessed before and 1 year after parathyroidectomy.

Setting

Referral center.

Patients

A total of 177 women with PHPT (62.5 ± 13.3 years, 83.1% menopausal, 43.9% osteopenic, and 45.1% osteoporotic) were included.

Intervention

Parathyroidectomy.

Main Outcome Measure

BMD change between before and 1 year after parathyroidectomy.

Results

Parathyroidectomy resulted in significant increase in BMD and decrease in serum bone remodeling biomarker concentrations. In the 72 patients with baseline osteopenia, mean BMD significantly increased at the lumbar spine [+0.05 g/cm2 (95% confidence interval [CI], 0.03–0.07)], the femoral neck [+0.02 g/cm2 (95% CI 0.00–0.04)], the total hip [+0.02 g/cm2 (95% CI 0.01–0.02)], and the forearm [+0.01 (95% CI 0.00–0.02)], comparable to osteoporotic patients. Among osteopenic patients, those with individual BMD gain (>0.03 g/cm2) at ≥1 site had higher preoperative serum CTX, P1NP, and urine calcium concentrations than those without improvement.

Conclusion

Parathyroidectomy significantly improved BMD and remodeling biomarkers in women with osteopenia, thereby supporting the benefit of parathyroidectomy in these patients. Preoperative serum CTX and P1NP concentrations could be useful to predict expected BMD gain.
Stably Unusual
Authors: Waller Thomas
Published: December 2023

This article critically compares two recent approaches to the problem of aesthetic autonomy: Dave Beech’s Art and Value and Nicholas Brown’s Autonomy. By recentering the differences between these critics’ works around Marx’s categories of subsumption, it evaluates the fraught relationship between labor and aesthetics, economy and form, art and the market. Although Beech provides a persuasive account of art’s “economic exceptionalism,” his focus on the qualitative irreducibility of artistic labor risks losing sight of what is socially unique about aesthetic production. Likewise, and inversely, while Brown’s original account of art’s internal overcoming of the commodity-form provides a generative way to rethink aesthetics in modernism’s wake, it rests on a periodizing claim for the total domination of the capitalist market that equivocates on whether artistic labor can truly be “really subsumed” under capital. The article concludes by pondering the political dimension to these theories of autonomy, which mirror in important ways debates within communization circles over subsumption, programmatism, and the aesthetics of revolution.
Cholangitis and Interruptions of Neoadjuvant Chemotherapy Associate with Reduced Overall and Progression-Free Survival in Pancreatic Cancer
Authors: Vehviläinen Sini , Kuuliala Antti , Udd Marianne , Nurmi Anna , Peltola Katriina , Haglund Caj , Kylänpää Leena , Seppänen Hanna
Published: December 2023

Background

Interrupting chemotherapy may explain the reduced overall survival (OS) in patients with pancreatic cancer (PC) with cholangitis. Endoscopic biliary decompression (BD) with metallic stents results in fewer chemotherapy interruptions and a lower cholangitis rate compared with plastic stents. We aimed to determine the impact of cholangitis, neoadjuvant treatment (NAT) interruptions and biliary stent choice on PC patients’ survival.

Methods

We conducted a retrospective analysis of 162 patients with cancer of the head of the pancreas undergoing pancreatoduodenectomy after NAT and BD documenting progression-free survival (PFS) and OS. Data on BD, cholangitis, stent type, surgical radicality, and chemotherapy were collected. Survival was estimated based on the Kaplan–Meier method by using the log-rank test and multivariate Cox regression analysis.

Results

Median OS and PFS for patients with cholangitis (n = 33, 20%) were 26 and 8 months (95% confidence interval [CI] 20–32 and 5–10 months), respectively, compared with 36 and 17 months (95% CI 31–41 and 12–21 months; p < 0.001 for OS; p = 0.002 for PFS) for patients without cholangitis. Among patients without NAT interruptions median OS and PFS were 35 and 17 months (95% CI 31–40 and 12–21 months), falling to 26 and 7 months (95% CI 18–30 and 5–10 months) among those who experienced an NAT interruption caused by biliary stent failure (n = 26, 16%) (p = 0.039 for OS; p < 0.001 for PFS). We found no difference in OS or PFS between stent types.

Conclusions

Cholangitis and NAT interruptions reduce OS and PFS among PC patients.
Solar flares with sustained gamma-ray emission and some characteristics of high-energy proton fluxes
Authors: Tomozov Vladimir , Minasyants Gennady , Minasyants Tamara
Published: December 2023

We describe the characteristics of long-term gamma fluxes with quantum energies >100 MeV, obtained from Fermi/LAT data during the impulsive phase of the most energetic flare phenomena. We compare GOES data on proton fluxes with energies >500 MeV with Fermi/LAT data on gamma fluxes for the period 2010–2018. The results of the analysis of all data obtained on 32 gamma-ray flares from the Fermi/LAT catalog show that the flare phenomena can be classified into three different types: type 1 — gamma fluxes accompanied by energetic proton fluxes; type 2 — gamma rays recorded in the absence of increases in proton fluxes; type 3 — gamma fluxes not recorded during observed increases in energetic proton fluxes. The burst character of energy release in the hard X-ray range was noted in some flares.
Dynamics of small-scale magnetic fields before small and large solar flares
Authors: Borovik Aleksandr , Zhdanov Anton
Published: December 2023

We have examined the dynamics of the longitudinal magnetic field of active region NOAA 12673, using data from the Solar Dynamics Observatory (SDO). During the passage of the active region (AR) across the solar disk, its spots and background fields showed complex motion trajectories, and numerous small-scale short-lived local polarity inversion lines (LPILs) were formed when new magnetic fluxes appeared in the AR and came closer to fields of opposite polarity. The length of LPILs was less than 15.000 km (~20 arcsec); their lifetime was several hours. Study of the flare activity of NOAA 12673 has shown that low-power flares (optical class S, area ˂2 sq. degrees) generally occur near LPILs. Before small flares and the September 06, 2017 large flare (optical importance 3B, X-ray class X9.3), in limited sites of local and main polarity inversion lines there were shear stresses and an increase in the magnetic field gradient: in the region of low-power flares, to 1.3–1.5 G/km; in the region of the large flare, 3–3.5 G/km. The results obtained suggest that the longitudinal magnetic field behaves similarly before both small and large flares.
Solution Representations for Poisson’s Equation, Martingale Structure, and the Markov Chain Central Limit Theorem
Authors: Glynn Peter W. , Infanger Alex
Published: December 2023

The solution of Poisson’s equation plays a key role in constructing the martingale through which sums of Markov correlated random variables can be analyzed. In this paper, we study three different representations for the solution for countable state space irreducible Markov chains, two based on entry time expectations, and the other based on a potential kernel. Our consideration of null recurrent chains allows us to extend our theory to positive recurrent nonexplosive Markov jump processes. We also develop the martingale structure induced by these solutions to Poisson’s equation, under minimal conditions, and establish verifiable Lyapunov conditions to support our theory. Finally, we provide a central limit theorem for Markov dependent sums, under conditions weaker than have previously appeared in the literature.
Formation of media competence of the military personnel of the Armed Forces of Ukraine as an efficient means of counteracting the enemy's information and psychological influence
Authors:   State Institution Luhansk Taras Shevchenko National University, Labenоk Oleksandr
Published: December 2023

The article substantiates one of the pedagogical conditions for the efficient formation of the sociopsychological readiness of the military personnel of the Armed Forces of Ukraine to perform assigned tasks in a hybrid war – the formation of media competence of military personnel as an efficient means of counteracting the enemy's information and psychological influence. The methods of generalization, comparison and systematization have been used to develop the theoretical and methodological basis for the process of forming media competence of military personnel in a hybrid war. It has been proven that the media competence of military personnel is the ability to analyze and critically evaluate information received through the media, including social media and news sources. It helps to distinguish objective information from fake news, understand the influence of media on public opinion and the ability to respond adequately to media manipulation. The purpose of media competence is to develop the skills of analyzing, evaluating and using media information, taking into account the peculiarities of hybrid warfare. Military personnel must be able to distinguish truthful and objective information from manipulative information, understand media strategies and tactics used by the enemy, and respond adequately to media challenges. One of the tasks is to ensure that military personnel are able to receive and disseminate information, taking into account its impact on the society and military activities.
Design, Synthesis, Molecular Docking, Invitro Anticancer and Antibacterial Evaluation of Novel Pyrazole Linked with Quinazoline Scaffolds
Authors: Afroz Mohd , kumar G Shiva
Published: December 2023

A novel series of compounds are synthesized N-(2-methyl-4-oxoquinazolin-3(4H)-yl)-3-oxo-3-(3,5-diphenyl-2H-pyrazol-1(5 H)-yl) propenamide (3a-l). All the synthesized compounds are characterized by different spectral tools 1HNMR, IR,13CNMR, and MASS. It was screened as in vitro anticancer and antibacterial activity. Among the synthesized compounds 3d and 3e exhibit potent against three cancer cell-line MCF7, PC-3, HT-29. IC50(µM) 3d (16.52, 13.24, 10.15 μg/ml) 3e (17.28, 15.26, 12.33 μg/ml) with standard drugs doxorubicin (15.29, 12.26, 9.06 μg/ml) and 5-fluorouracil (16.15, 13.73, 10.25 μg/ml). Antibacterial activity 3d, 3e, 3j, 3k scaffolds exhibit a promising activity with the standard drug ciprofloxacin. Insilico molecular docking is examined, Its predicted a good binding affinity against with 5C5S, 6XXN, 3K46 proteins.
Great Toe Osteoid Osteoma with Atypical Presentation: A Case Report
Authors:   Department of Orthopaedics, All India Institute of Medical Sciences (AIIMS), New Delhi, India,, Jarolia Mansingh , Chauhan Nitin ,   Department of Orthopaedics, All India Institute of Medical Sciences (AIIMS), New Delhi, India,, M L V Sai Krishna ,   Department of Orthopaedics, Aayush Hospitals, Eluru, India,, Gamangatti Shivanand ,   Department of Radiology, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Published: December 2023

Introduction: Osteoid osteoma is a common benign osteoblastic lesion of the bone. Although it commonly affects the cortex of long bones, it rarely involves the cancellous portion of the small bones such as phalanges. The occurrence of osteoid osteoma in phalanges poses a diagnostic dilemma. Case Report: In our case report, we presented a 26-year-old patient with long-standing pain over the great toe. The radiographs and magnetic resonance imaging (MRI) were unable to diagnose the lesion, and a single-photon emission computerized tomography scan picked up the nidus. She underwent radiofrequency ablation and post-procedure she was relieved of her symptoms. Conclusion: Osteoid osteoma of the phalanges is uncommon, and at times, routine radiographs and MRIs might not point us to the correct diagnosis. As the prognosis is excellent after the treatment is instituted, osteoid osteoma should always be a differential in chronic foot pain with nocturnal predominance. Keywords: Osteoid osteoma, chronic foot pain, radio frequency ablation.
Exploitation, Capitalist Crisis, and Democratic Planning: Problems of Piketty’s Socialism
Authors: Noonan Jeff
Published: December 2023

Thomas Piketty is the most politically and economically important participant in the ongoing debate about the deleterious effects of income and wealth inequality. The article analyses his arguments carefully because they give Marxists an opportunity to intervene in a mainstream political-economic debate in which they are generally not taken seriously. As impressive as Piketty’s argument is, and as willing as he is to embrace a socialist solution to capitalist crisis, a non-dogmatic Marxist examination of his texts reveals that his argument does not grasp at the most systematic level the connections between the driving forces of the capitalist economy and the undemocratic implications of widening inequality. This article will argue that although his critique acknowledges the structural inequality of power between workers and capitalists upon which capitalist society depends, his argument points towards an organic link between the exploitation of labour, the falling rate of profit, capitalist crisis, the shift of investment from the productive economy to the financial sector, and growing inequality that he does not explicitly formulate.
The Opium Wars and Capital Accumulation: Comments on Karl Marx’s Perspectives on the Qing and England Recorded in The New York Herald Tribune
Authors: Xie Hongren
Published: December 2023

Karl Marx, a pioneer of anti-imperialism (or anti-mercantilism), was exiled in the 1850s in London. A decade later, he wrote nearly 500 editorials for The New York Herald Tribune. Although a handful of these editorials offer important clues for understanding Marx’s thinking on imperialism, these writings have been largely ignored. This study fleshes out Marx’s thinking, especially with respect to the relationship between wars and capital accumulation. This article employs the example of the Second Opium War, launched in the mid-1850s. The dominant Western powers at the time, such as Great Britain and France, advocated mercantilism, usually supported by military force, and regarded wars as a quick method to accumulate capital for national wealth. Additionally, Britain skillfully maneuvered its cultural hegemony by using its official periodical, The Economist, to legitimize the wars against Qing China. In the mid-nineteenth century, Marx had already clearly observed the close relationship between the Opium Wars and capital accumulation.
Sub-wavelength scale characterization of on-chip coupling mirrors
Authors: Tkachuk V. V. , Korterik J. P. , Chang L. , Offerhaus H. L.
Published: December 2023

Miniature free-space optical beams, originating from on-chip microstructures, are usually measured and quoted without reference to a particular polarization state. We develop an automated platform to characterize tightly focused free-space optical beams in three dimensions. We present a detailed description of each subsystem including the calibration and test procedure. We demonstrate how amplitude and phase are measured at sub-wavelength resolution using a cleaved fiber with a heterodyne reference. Further analysis provides information about the phase and intensity profile of the beam with regards to its polarization content and spatial confinement. We perform a proof-of-concept experiment for a custom waveguide-coupled micro-mirror. The work opens new possibilities for rapid analysis of micro-mirrors in prototyping and optimization of integrated optical systems.
Developing and testing the feasibility of a new internet-based intervention–A case study of people with stroke and occupational therapists
Authors: Barcheus Ida-Maria , Ranner Maria , Nyman Anneli , Månsson Lexell Eva , Larsson-Lund Maria
Published: December 2023

Introduction

Internet-based interventions are called for within rehabilitation to meet the limited access to support for self-management after stroke. Therefore, a new intervention program, “Strategies for Empowering activities in Everyday life” (SEE) was developed. The aim of this study was to explore and describe how clients with stroke and their occupational therapists experienced the SEE intervention process and whether SEE has the potential to promote an active everyday life.

Methods

A qualitative descriptive case study was designed. Four people with stroke (two of each sex, mean age 66,5 years) and their two occupational therapists (one of each sex) were included. A mix of data collection methods as interviews, assessments, registration forms and fieldnotes was used to uncover the participants’ experiences and potential changes. Data were analysed with pattern matching.

Findings

The analysed data formed three categories: “Not being able to take on the internet-based intervention”, “Being facilitated in the change process of everyday life through the internet-based intervention”, and “Providing a new internet-based intervention is a transition from ordinary practice”. These categories included two to four subcategories that reflected aspects of SEE feasibility and acceptability with a focus on content and delivery.

Conclusion

The first test of the intervention indicates that the content and delivery of SEE can be feasible and acceptable both for clients and occupational therapists. The findings suggest that SEE has the potential to support clients’ self-reflections and their adoption of strategies that influence engagement in daily activities and satisfaction with life in various ways. Further research with large-scale studies is needed.
EXAMPLE CRIMINOLOGICAL DETERMINANTS OF THE SPREAD OF THE IDEOLOGY OF TERRORISM IN EDUCATIONAL ORGANIZATIONS OF HIGHER EDUCATION AND PROFESSIONAL EDUCATIONAL ORGANIZATIONS
Authors: Стародубцева М.А.
Published: December 2023

The article examines the facts of the spread of the ideology of terrorism in educational organizationsas manifestations of «idealistic» terrorism, according to the classification proposed by Yu.M. Antonyan.From the point of view of criminology, terrorism is understood as a diverse phenomenon. In this regard,it is necessary to determine what type of terrorism educational organizations face. Next, it is necessary tohighlight the determinants of the spread of the ideology of terrorism in educational organizations.The analysis of criminal cases according to the elements of Art. 205.2 of the Criminal Code of theRussian Federation and a survey of teachers and teachers of a number of educational organizations in theAltai Territory makes it possible to determine the determinants of the spread of the ideology of terrorismin educational organizations. The traditional division of the determinants of crime into general social,socio-psychological and personal needs to be clarified in relation to terrorist crimes committed by youngpeople studying in educational organizations. Among the general social determinants of terrorist crime in  educational organizations, the main role is played by the social qualities of young people. Among the sociopsychological determinants, the main role is played by shortcomings in family education and the formalismof preventive measures. The analysis of criminal cases allows us to conclude that among the families of thoseaccused and on trial for committing terrorist crimes in educational organizations, pedagogically incorrectlyoriented families prevail, where, for one reason or another, psychological contact with the child has notbeen established.
MODEL LEGISLATION OF THE CIS MEMBER STATES ON JURY TRIALS
Authors: Dudko N.A.
Published: December 2023

The article considers the issue of inter-parliamentary cooperation of the member states of theCommonwealth of Independent States (CIS), formed in 1991. The main form of inter-parliamentarycooperation of the member states of the Commonwealth of Independent States is model lawmaking. As aresult of a comparative legal study, it was concluded that the model legislation of the Commonwealth ofIndependent States and the national legislation of the CIS member states, in particular the legislation ontrial with the participation of jurors, are interrelated and mutually influenced. The subject of the study wasthe norms of the “Model Criminal Procedure Code for the CIS Member States” in 1996 and the norms ofthe “Model Code on the Judicial System and the Status of Judges for the CIS Member States” in 2011. Thegeneral tendency to improve the judicial systems of the Russian Federation, the Republic of Kazakhstan, theKyrgyz Republic was revealed — the legislative consolidation of the possibility of considering criminal casesby a court with the participation of jurors. In the Russian Federation and the Republic of Kazakhstan, thecourt with the participation of jurors is successfully functioning, in the Kyrgyz Republic it will be introducedin January 2025.
“KARAMOLA RULES” — THE RESULT OF ABAI’S LAWMAKING
Authors: Matayeva M.H.
Published: December 2023

The article analyzes the code of laws “Rules of Karamola”, compiled by Abai to regulate public relationsin Kazakh society at the end of the nineteenth century. The significant role of Abai in the compilation of thecode of laws, his humane attitude to crimes committed against women is noted. The great importance ofthe norms on criminal and criminal procedure law of the late nineteenth century for the improvement ofmodern legislation of the Republic of Kazakhstan is emphasized.
Structured program for therapeutic education of type 2 diabetes patients
Authors:   Endocrinology Research Centre, Mayorov Aleksandr , Melnikova Olga , Philippov Yury , Ibragimova Liudmila , Mikhina Margarita , Motovilin Oleg , Makolina Natalia , Romanenkova Elizaveta , Shestakova Ekaterina , Galstyan Gagik , Shestakova Marina
Published: December 2023

The manual for healthcare professionals and nurses to be used for the education of type 2 diabetes mellitus patients receiving insulin therapy was developed by the employees of Endocrinology Research Centre in accordance with clinical guidelines, WHO recommendations and is based on the principle of structuring patient education. The manual contains a plan of classes and topics necessary for patients. The content of the classes is presented in a language understandable to the patients. Specific medical terminology is not used. Education of patients using the proposed program can be carried out both in the in-patients hospital and on an outpatient basis, depending on the conditions available in a particular medical institution. Approved and recommended for use by the Russian Association of Endocrinologists.
A Systematic Review and Comparative Meta-analysis of Non-destructive Fruit Maturity Detection Techniques
Authors: Rani Neetu , Garg Savita , Bamel Kiran , Bhatt Vaibhav , Sharma Sourabh , Mishra Shashvat Kumar , Saini Nitesh , Parmar Saloni
Published: December 2023

The global fruit industry is growing rapidly due to increased awareness of the health benefits associated with fruit consumption. Fruit maturity detection plays a crucial role in fruit logistics and maintenance, enabling farmers and fruit industries to grade fruits and develop sustainable policies for enhanced profitability and service quality. Non-destructive fruit maturity detection methods have gained significant attention, especially with advancements in machine vision and spectroscopic techniques. This systematic review provides a concise overview of the techniques and algorithms used in fruit quality grading by farmers and industries. The study reviewed 63 full-text articles published between 2012 and 2023 along with their bibliometric analysis. Qualitative analysis revealed that researchers from various disciplines contributed to this field, with techniques falling into 3 categories: machine vision (mathematical modelling or deep learning), spectroscopy and other miscellaneous approaches. There was a high level of diversity among these categories, as indicated by an I-square value of 88.37% in the heterogeneity analysis. Meta-analysis, using odds ratios as the effect measure, established the relationship between techniques and their accuracy. Machine vision showed a positive correlation with accuracy across different categories. Additionally, Egger's and Begg's tests were used to assess publication bias and no strong evidence of its occurrence was found. This study offers valuable insights into the advantages and limitations of various fruit maturity detection techniques. For employing statistical and meta-analytical methods, key factors such as accuracy and sample size have been considered. These findings will aid in the development of effective strategies for fruit quality assessment.
Rola południowokoreańskich artystów muzyki popularnej w promowaniu idei ochrony środowiska
Authors: Ludek Weronika
Published: December 2023

Niniejsza publikacja ma na celu przybliżenie roli, jaką odgrywa południowokoreańska muzyka popularna w procesie rozprzestrzeniania się idei dotyczących zmian klimatycznych oraz konieczności podejmowania działań dążących do ich minimalizacji. W tym celu w artykule opisano, w jaki sposób k-pop akceleruje zmiany zachowań w obrębie miłośników tego gatunku, odwołując się do takich konceptów jak kultura partycypacji. Podkreślono także szczególne znaczenie aktywizmu fanów w procesie edukacji i promowania postaw proekologicznych. Ponadto sprecyzowano działania wokalistów, które przyczyniają się do zmian, uwzględniając ich aktywności zarówno w sektorze publicznym, jak i prywatnym.
Modeling quality and prestige in applied linguistics journals: A bibliometric and synthetic analysis
Authors: Xu Yiran , Zhuang Jingyuan , Blair Ryan , Kim Amy I. , Li Fei , Hernández Rachel Thorson , Plonsky Luke
Published: December 2023

The importance of academic journals in second language (L2) research is evident on at least two levels. Journals are, first of all, central to the process of disseminating scientific findings. Journals are also critical on a professional level as most L2 researchers must publish articles to advance their careers. However, not all journals are perceived as equal; some may be considered more prestigious or of higher quality and may, therefore, achieve a greater impact on the field. It is therefore necessary that we understand the identity and quality of L2 research journals, yet very little research (e.g., Egbert, 2007; VanPatten & Williams, 2002) has considered these issues to date. The current study sought to explore L2 journal identity and quality, and the relationship between these constructs. In order to do so, a database was compiled based on three different types of sources: (1) a questionnaire eliciting L2 researchers’ perceptions of the quality and prestige of 27 journals that publish L2 research (N = 327); (2) manual coding of different types of articles (e.g., empirical studies, review papers), data (quantitative, qualitative, mixed), research settings, and authorship patterns (K = 2,024) using the same 27 journals; and (3) bibliometric and submission data such as impact factors, citation counts, and acceptance rates. Descriptive statistics were applied to explore overall quality and prestige ratings as well as publication trends found in each journal. The relationships between those patterns and subjective ratings were also examined. In addition, regression models were built to determine the extent to which perceptions of journal quality and prestige could be explained as a function of journal and article features. We discuss the findings of the study in terms of on-going debates concerning publication practices, study quality, impact factors, journal selection, and the “journal culture” in applied linguistics.
Mental Revival of Ukraine: A Stranger Among Friends?
Authors: Lavrynenko Hanna , Donaj Łukasz
Published: December 2023

The authors of the study analyze the problem of the mental revival of Ukrainians in the post-war period, as well as consequences of the division of society into the categories of “friends” and “strangers”. The authors distinguish three stages in which the Ukrainian society distanced itself from Soviet political system values in the transition from homo soveticus to the modern Ukrainian political mentality: political distillation, sublimation and calcination. Two waves of internal migrants in independent Ukraine have been identified: the first in 2014–2015, and the second and after February 24, 2022. The study focuses on the profession as an indicator for the level of political awareness among citizens. It is noted that since the beginning of the hybrid war, there has been a division of Ukrainian society into those who left and those who remained to live under occupation. The attention is also paid to the importance of understanding the motivation and behavior of these people, as well as reasons for making decisions in favor of or against cooperation with the occupants. The issue of potential and existing manifestations of collaboration in the occupied territories is analyzed. By using the “triangle of power and relations by Stephen Karpman”, the article examines general sentiments of Ukrainians on the division of their society into “friends” (“heroes”) and “strangers” (“traitors”) during military operations in Ukraine. The authors analyze communication and behavior types of citizens within three models: “victim”, “traitor” and “hero”. The study indicates that citizens who were and were not in the occupied territory are wary of each other; several scenarios of relations between them are identified. The first is acceptance as “friends”, a manifestation of compassion, a tolerant attitude, and willingness to help the “victim”. Another scenario is non-acceptance by the community, assignment to the category of “stranger”, and tense and suspicious attitude towards the “traitor”. The authors note that, in the post-war period, another division of society is likely to be observed, but not on the basis of the language or territory, but on the actual place of residence of citizens (in territories occupied or controlled by Ukraine) during hostilities.
A study of forensic genetics: ITO index distribution and kinship judgment between two individuals
Authors: Jiang Huanchang , Jiang Qinglian , Wu Shuzhen
Published: December 2023

According to Mendel’s law of genetic separation, there must be a certain blood relationship between members of the same family, and two individuals with blood relations must have the following three situations, that is, there are two homologous genes (I denotes), one homologous gene (T denotes), and no homologous genes (O denotes), which is the ITO index for calculating the blood relationship between two individuals. The AGGU Expressmarker 22 kit, ABI 3500 genetic analyzer, and GeneMapper ID-X v1.5 software were used to statistically analyze the ITO index of the gene locus of 5 kinds of samples, 28 pairs of monozygotic twins (MT), 4,000 pairs of parent–offspring (PO), 392 pairs of full sibling (FS), 138 pairs of half-siblings (HS) (including grandchildren, uncles, and nephews) and 3,500 pairs of unrelated individuals (UI). Observing the median distribution of ITO index found that from MT, PO, FS, HS to UI, the more distant the kinship, the smaller the ITO index. Full sibling index (FSI)/half-sibling index (HSI) ≥ 1 can be used as the FS discriminant standard, FSI/HSI < 1 can be used as the HS discriminant standard. According to the distance of kinship, from the direction of MT, PO, FS, HS, and UI, the proportion of the maximum ITO index of the same type of sample in the true kinship index item showed a decreasing trend. ITO index is an important statistical means to identify the kinship between two individuals, according to which the ITO index can accurately determine the kinship between individuals, which has high application value. MT index is not 0 to identify relatives as MT, PO index is an important indicator to distinguish between relatives as PO and FS. The critical values of ITO index discriminant values for UI and HS need to be further studied.
From the Editors
Authors: Fox Jesse , Kugelmann Robert
Published: December 2023

With this issue, Integratus completes its first year. A new journal faces many challenges, being an unknown entity. Submissions can arrive haltingly, and the journal needs a good team of peer reviewers. These things take time. Today there is a good stream of new submissions to the journal, and our review team (to use a sports analogy) may not be Super Bowl champs, but they are in the playoffs with timely and insightful reviews.
Evaluation of efficacy of photodynamic disinfection against enterococcus faecalis and compare it with the effect of different endodontic irrigant activation techniques.
Authors:   Department: Conservative Dentistry, College: College of Dentistry University: University of Duhok, City: Duhok, Iraq., Haskiyal Amanda George , Saeed Dara Hamarashid
Published: December 2023

Background and objective: The aim of this in vitro study was to assess the efficacy of photodynamic disinfection against Enterococcus faecalis, and compare it with the effect of different endodontic irrigant activation techniques. Methods: Fifty single-rooted premolars with single canals were chosen for the study. Five teeth were chosen to serve as the negative control group. The remaining samples were infected with normal Enterococcus faecalis strains. They were then randomly separated into five groups, with nine teeth serving as a positive control group (E. Cont.). Each group consisted of 9 samples based on the kind of irrigant activation: E.A (Diode laser), E.B (Ultrasonic), E.C (conventional), and E.D (FotoSan). The ProTaper NEXT rotary system up to model X3 was used to prepare all samples. For each group, 5.25% NaOCl was injected as an initial irrigant with a 30G double-side vented syringe needle, followed by 17% EDTA, then activated with NaOCl as a final irrigant. CFU of each sample was counted before and after irrigation regime, and they were compared to the control group. The efficiency of the disinfection techniques was determined using scanning electron microscopes (SEM). Result: The quantity of bacterial colony counting revealed that the control group had the largest mean of a bacterial colony (135.56±50.58); while the FotoSan group had the lowest colony mean number (23.11±9.82). SEM results indicated that the FotoSan group (5.56±3.16) and Diode laser (5.56±3.57) had the lowest surviving colony mean number. Conclusion: As an additional method, photodynamic therapy may increase the disinfection capacity of traditional endodontic treatment against E. faecalis in the root canal. Keywords:photodynamic disinfection, enterococcus faecalis, endodontic irrigant activation
Effect of Clinical Sandblasting on the Surface Roughness of Zirconia Cores for all Ceramic Crowns and their Fracture Resistance after the Addition of Repair.
Authors:   University of Sulaimani, college of Dentistry., Yassin Mohammed Thamir , Salih Shatha Abdullah
Published: December 2023

Objective: This in vitro study aims to evaluate the effect of clinical sandblasting with 50 μm aluminum oxide and 30 μm silica-coated particles on the surface roughness of zirconia cores and the subsequent effect on their fracture resistance after veneering with composite using a specific repair kit. Materials and Methods: Zirconia cores (n=21) were digitally designed and milled from ZirCAD LT B1 (IPS e.max ZirCAD ) blocks using arum 5x-300 Pro (ARUM DENTISTRY). These cores were randomly divided into three groups: Group A: n=8, sandblasted with 50 μm aluminum oxide, and veneered with packable Z350 composite. Group B: n=8, sandblasted with 30 μm silicacoated particles and veneered with packable Z350 composite. Group C: control group (n=5), sandblasted in the laboratory with 110 μm aluminum oxide and veneered with porcelain (Vintage Zr PRO - SHOFU Dental GmbH). All the specimens were tested for surface roughness by the TAYLOR-HOBSON profilometer. After adding veneering material, all the specimens were subjected to a fracture resistance test through a universal testing machine. Results: One-way ANOVA test showed a significantly higher surface roughness in group B compared to group A. Fracture resistance values showed no significant difference between all the groups. Conclusion: Silica-coated particles produced higher surface roughness than aluminum oxide alone. The fracture resistance values of all the groups were above the acceptable clinical limit. Keywords: Aluminum-oxide, Intra-oral repair, Sandblasting, Silica, Surface Roughness, Zirconia
Sprachtandems als Instrument zur Förderung und Bewertung der interkulturellen kommunikativen Kompetenz im Sprachlernprozess Deutsch-Spanisch
Authors: Strohschen Carola
Published: December 2023

Ausgangspunkt des vorliegenden Beitrags ist ein virtuelles Sprachtandem zwischen spanisch- und deutschlernenden Studierenden der Universitäten Trier (Deutschland) und Murcia (Spanien). Die Sitzungen des Sprachaustausches, die wöchentlich im Zeitraum eines Semesters in Paaren und per Videokonferenz stattfanden, wurden aufgezeichnet und dienten als Grundlage für die Erarbeitung eines Bewertungsrasters, dessen Validität anschließend an den Projektergebnissen selbst überprüft wurde. Der Einsatz eines Erhebungsbogens, in dem die Teilnehmenden zu interkulturellen Aspekten und ihrer konkreten persönlichen Entwicklung diesbezüglich befragt wurden, diente den Dozentinnen zur internen Bewertung und zur Überprüfung des Erreichens der Projektziele. Beide Methoden, sowohl das Bewertungsraster als auch der Erhebungsbogen, stellten sich als valide Werkzeuge zur Bewertung der interkulturellen Kompetenz heraus.
Treatment of Endocrine Pollutants Upstream of the Wadis Tghat and Zhoun of the City of Fez by Coagulation-Flocculation (Morocco)
Authors: Madani Fatima-Zahra El , Idrissi Nisrine , Allaoui Nouha El , Abbou Mohamed Ben , Rais Zakia , Taleb Mustapha
Published: December 2023

In recent years, the quality of the surface water of the city of Fez has deteriorated due to the development of various anthropic activities, ill-considered modernization, unregulated discharge of wastewater and solid waste. This is a worrying threat to human health and the environment. Previous studies on these wadis have shown that Tghat and Zhoun wadis are the most polluted [1]; [2]; [3]. Adequate treatment of effluents upstream is therefore of crucial importance. The objective of this study is to contribute to the treatment of endocrine pollutants discharged upstream of these two wadis after their characterization and monitoring of their pollutant load for six months (El Madani et al., 2019). The most polluted wadis of the city of Fez [2] by coagulation-flocculation.The results showed that these effluents have a medium faecal load and are loaded by organic pollution at the limit of biodegradability rich in nitrogen and phosphorus matter and a high metallic load with endocrine disrupting effect, mainly Cr, As, Pb and Cd.The treatment of these pollutants by coagulation-flocculation with aluminum sulphate of the effluents studied under optimal conditions of pH, a dose of coagulant and flocculant and coagulation and flocculation agitation speeds, allowed the reduction of almost all the organic matter and 90 to 96% of the metal load.
Les mouvements dans l'espace Yn
Authors: Urbonas Algimantas Pranas
Published: December 2023

Dans cet article on trouve les équations des mouvements dans l'espace Yn conservants la con­nexion linéaire de cet espace. En même temps on a obtenu les premières séries des équations d'intégration.
Data mining approach on information detection using intelligent miner for data
Authors: Kulvietienė Regina , Mamčenko Jelena
Published: December 2023

There is not abstract.
Abdominal viscera in the thoracic cavity: a case of large Bochdalek hernia in an adult
Authors: Zeinalpour Adel , Ebrahimibagha Hamed , Ehsani Mohammadhosein , Jamalian Matin
Published: December 2023

Introduction: Bochdaleck hernias (BH) are a congenital defect in the diaphragm's postero lateral part that may cause the abdominal viscera's protrusion into the chest cavity. This type of hernia is rare in adults. Most cases are referred to the emergency department with gastrointestinal obstruction and visceral strangulation symptoms. Case presentation: A 50-year-old man was referred to the emergency department complaining of abdominal pain in the left upper quadrant, intermittent vomiting, and pain in the left hemithorax from one day ago. We found a large diaphragmatic hernia on the left side during evaluation, which causes intra-abdominal organ shift to the left hemithorax. The patient underwent surgery for diaphragmatic herniorrhaphy. Conclusion: Congenital diaphragmatic Bochdaleck hernias are rare and are associated with nonspecific symptoms in adults. They may be symptom-free during the patient's life as in our case. It is necessary to investigate more cases and long-term follow-ups of patients, to improve the diagnosis and treatment of these patients.