bluuebunny/crossref_metadata_2025 huggingface dataset:
Bubble buoyancy produces non-conserved energy multiplication experiments
Authors: Feng Zhengyi
Published: September 2024

“Energy neither disappears nor is it generated, it is only transformed from one form to another, and in the process of transformation and transfer, the total amount of energy remains the same—law ofconservation of eaergy.” It was established in experiments by several scientists, including Meyer, Joule, etc. Science has never produced energy. Only petrochemical and nuclear materials can be converted to heat and electricity, causing excessive carbon emissions and nuclear pollution. My experiments revealed that the axiom that energy cannot disappear is accurate. The buoyancy of bubbles input underwater can be greater than the pressure at the inlet, Bubble buoyancy can produce non-conserved power or heat; this finding has a wide range of applications, including the correction of astrophysics errors. Promote energy freedom and sustainable development, food security. Play the most important role in replacing carbon emissions.
Nageotte nodules in human DRG reveal neurodegeneration in painful diabetic neuropathy
Authors: Price Theodore , Shiers Stephanie , Mazhar Khadijah , Wangzhou Andi , Haberberger Rainer , Lesnak Joseph , Sankaranarayanan Ishwarya , Tavares-Ferreira Diana , Cervantes Anna , Funk Geoffrey , Horton Peter , Vines Erin , Dussor Gregory
Published: September 2024

Diabetic neuropathy is frequently accompanied by pain and loss of sensation attributed to axonal dieback. We recovered dorsal root ganglia (DRGs) from 90 organ donors, 19 of whom had medical indices for diabetic painful neuropathy (DPN). Nageotte nodules, dead sensory neurons engulfed by non-neuronal cells, were abundant in DPN DRGs and accounted for 25% of all neurons. Peripherin-and Nav1.7-positive dystrophic axons invaded Nageotte nodules, forming small neuroma-like structures. Using histology and spatial sequencing, we demonstrate that Nageotte nodules are mainly composed of satellite glia and non-myelinating Schwann cells that express SPP1 and are intertwined with sprouting sensory axons originating from neighboring neurons. Our findings solve a 100-year mystery of the nature of Nageotte nodules linking these pathological structures to pain and sensory loss in DPN.
Investigating the Potential Accessibility to HIV Pre-Exposure Prophylaxis viaCommunity Pharmacies and Sexual Health Clinics: A Scoping Review of Two Integrated Care Systems in London
Authors: Alaa Aos , Mujong Datapwa , Lakhani Shivali , Alter Marsha , El-Osta Austen
Published: September 2024

Background HIV prevalence in North West London (NWL & NCL) & North Central London is either high or very high for England across the eight boroughs. Despite advancements in HIV prevention, barriers and disparities in accessing Pre-exposure Prophylaxis (PrEP) from specialist services persist. Community pharmacies, with their extensive reach in London, offer an opportunity to reduce these disparities and help end new HIV infectionsObjective This study aims to investigate the accessibility of HIV PrEP through community pharmacies and sexual health clinics (SHCs) across two London Integrated Care Systems (ICS) and assess the potential for community pharmacies to enhance access to PrEP and to address existing gaps in PrEP provision to gauge the potential for community pharmacies to facilitate easier access to PrEP.Methods We mapped the distribution of pharmacies, PrEP clinics, and SHCs across 11 local authority areas in London, covering NWL ICS and three catchment areas from NCL ICS using publicly available data, including postcode data. Our selection process for sources of evidence was guided by a set of predefined criteria aimed at identifying community pharmacies and SHCs within the targeted ICSs for their relevance to HIV PrEP accessibility. Two reviewers systematically charted data from each included source. Information extracted included the name of the pharmacy or clinic, address, contact details and operating hours.Results Our data collection, spanning from April to July 2022, included 692 community pharmacies. The study revealed that 78.4% of these pharmacies offered sexual health services, with a significant proportion categorised at Tier 2 according to the Umbrella Sexual Health Model, indicating they are well-positioned to offer PrEP services. The mapping showed an uneven distribution of PrEP and sexual health clinics, with community pharmacies widely accessible and offering longer service hours.Conclusion The findings highlight the critical role community pharmacies could play in providing PrEP, addressing gaps in accessibility, and reducing HIV transmission risks, thus potentially facilitating easier access to PrEP. This study supports the need for policy adjustments to enable community pharmacies to dispense PrEP, aligning with public health goals for broader access to HIV preventative measures.
Development of a national osteopathic practice-based research network: the NCOR Research Network
Authors: Draper-Rodi Jerry , Fawkes Carol , Bailey Daniel
Published: September 2024

Objectives: To describe the development of the NCOR Research Network, the first osteopathic Practice-Based Research Network (PBRN) in the UK, and provide data on its members' characteristics, clinical practices, and patient demographics.
Design: Cross-sectional survey study.
Setting: Online survey of osteopaths practising in the United Kingdom.
Participants: 570 osteopaths registered with the General Osteopathic Council who consented to participate in the NCOR Research Network.
Primary and secondary outcome measures: Demographic characteristics of osteopaths, details of their clinical practice, patient demographics, common presenting complaints, treatment approaches, and attitudes towards evidence-based practice.
Results: The median age bracket of participants was 50-59 years, with 55% identifying as women. Participants had a median of 17 years of clinical experience. Most worked in private practice (71% as principals, 32% as associates), seeing 20-39 hours of patients per week. The majority (87%) regularly treated adults aged 65 or older. Low back pain was the most common complaint seen daily (56%). Spinal articulation/mobilization (79%) and soft tissue massage (78%) were the most frequently used techniques. Participants reported positive views towards evidence-based practice but cited lack of research skills and time as barriers to engagement.
Conclusions: The NCOR Research Network provides a foundation for future osteopathic research in the UK. While the sample was not fully representative of UK osteopaths, it offers insights into current osteopathic practice. The network aims to foster collaboration between clinicians and academics, potentially bridging the gap between research and practice in osteopathy.
Protocol registration: https://doi.org/10.17605/OSF.IO/HPWG4
Radiological findings in patients with Nasal Polyposis and its relation with chronic allergic disease
Authors: shebli Haya , Ajloni Helen , Nahas Louei Darjazini
Published: September 2024

Introduction:
Nasal polyposis is a prevalent chronic inflammatory condition affecting the nasal cavity and paranasal sinuses, leading to significant morbidity and reduced quality of life. Characterized by non-cancerous mucosal growths, nasal polyps result from ongoing inflammation and commonly obstruct airflow, causing distressing symptoms. This study investigates the radiological characteristics of nasal polyposis and their correlation with chronic allergic diseases, particularly allergic rhinitis and asthma.
Methods
A retrospective study was conducted at Damascus Hospital, Syria, analyzing medical records, radiological reports, and surgical findings of 110 patients diagnosed with nasal polyposis from January 2015 to September 2019. A structured questionnaire gathered demographic and clinical data. Radiological assessments were performed using the Lund-Mackay scoring system, while surgical classifications were based on the presence of polyps in specific sinuses. Statistical analyses, including descriptive statistics and t-tests, were employed to identify significant relationships between variables.
Results
The cohort included 57 males (51.8%) and 53 females (48.2%), with a mean age of 37.3 years. Predominant symptoms included nasal obstruction (98.2%), anterior rhinorrhea (80.9%), and hyposmia (80%). Asthma was present in 30% of participants, and aspirin sensitivity was noted in 24.5%. Statistically significant associations were observed between higher radiological and surgical scores and the presence of asthma (p = 0.003 and p = 0.001, respectively), as well as with aspirin sensitivity (p = 0.004 and p = 0.002). No significant correlations were found between classifications and allergic symptoms or sleep apnea.
Discussion
The findings align with previous studies highlighting the relationship between nasal polyposis, asthma, and aspirin sensitivity. Our study’s prevalence rates for asthma and allergic symptoms are consistent with existing literature. Higher polyp scores correlate with asthma presence, suggesting shared inflammatory pathways.
Conclusion
This research underscores the importance of radiological evaluations in understanding nasal polyposis and its associations with chronic allergic diseases. Improved insights into these relationships may enhance diagnostic accuracy and inform targeted therapeutic strategies for affected patients.
Guided Bone Regeneration in the Anterior Maxillary Region for the Installation of Implant Supported Single Restorations
Authors: Frigério Paula Buzo , Inoue Bruna Kaori Namba , Souza Ana Carla Gonçales de , Fantasia Ricardo , Freitas Marco Túlio Delaim de , Fernandes e Oliveira Hiskell Francine , Aparecido Araújo Lemos Cleidiel , Batista Victor Eduardo de Souza , Verri Fellippo Ramos
Published: September 2024

The use of methods to promote tissue regeneration has been widely used in implantology in clinical situations where there are bone deficiencies and anatomical limitations to install implants. The evolution of biomaterials has facilitating clinical resolution for the installation of implants with a safe and reliable prognosis. The advantage is to promote greater comfort, function and aesthetics, in addition to preserving the surrounding soft tissues. This clinical report illustrates an implant supported rehabilitation using bovine grafting to promote guided bone regeneration (GBR) in the same chair time and resulting in osseointegration of the implants. The patient received cone-morse dental implants in the anterior maxilla, and bovine biomaterial (Bio-Oss®) protected by a resorbable collagen membrane. After installing the implants, immediate provisionals were made and after the osseointegration period, second-stage surgery was performed and new provisionals were made. The definitive prosthesis was finalized involving other adjacent elements as previous clinical planning. We conclude that the GBR technique contributed to the successful treatment and osseointegration of the titanium implants besides improvement of soft contour of anterior region. The patient was satisfied in terms of aesthetics and function.
DEVELOPMENT OF A VOLTAMMETRIC METHOD FOR THE SIMULTANEOUS DETERMINATION OF PESTICIDES IN SURFACE WATER USING A COMPOSITE ELECTRODE
Authors: Barros Ferreira da Silva Gleiciane , Ferreira Amaral Mateus , Perin Bezerra Felipe , Terezo Ailton José , Castilho Marilza
Published: September 2024

A method was developed and validated for the simultaneous quantification of pesticides carbendazim (CBZ), diuron (DI) and carbofuran (CF) in surface water using a sustainable, handmade, and low-cost composite electrode (CE) based on graphite and polycaprolactone (PCL). The cyclic voltammetric (CV) results showed a quasi-reversible oxidation peak for CBZ around +0.76 V, and an irreversible oxidation peak for DI and CF at +0.88 and +1.32 V, respectively. Under optimized conditions, the anodic peak currents were proportional over ranges of 5.0-1059.0 µg L-1 for the binary analysis of CBZ and DI, with detection limits of 4.0 and 18.0 µg L-1, and limits of quantitation of 13.0 and 55.0 µg L-1, respectively. The proposed electrochemical method also exhibited good repeatability (n = 10) and intermediate precision (n = 3), with a relative standard deviation of 5%. In addition, the method successfully determined CBZ and DI in surface water samples without any sample pretreatment. Comparison with the reference chromatographic method ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) showed no significant differences at a 95% confidence level, demonstrating the applicability of the method. Additionally, the composite electrode offers advantages such as low cost, easy manufacturing, and simple operation.
VESTÍGIOS DO DERRAME DE PETRÓLEO DE 2019: AVALIAÇÃO DA PRESENÇA DE HPA E BTEX EM PRODUTOS DE PESCA
Authors: F. Bertoldi Crislaine , G. Dolatto Rafael , F. L. de Oliveira Luiz , F. Reis Lennon , Canela Maria C. , T. B. de Mélo Julyanne , da S. Rodrigues Abinoan , P. Paim Ana , Grassi Marco T.
Published: September 2024

ECHOES OF THE OIL SPILL OF 2019: ASSESSMENT OF THE PRESENCE OF PAH AND BTEX IN PRODUCTS FROM FISHING. The 2019 oil spill in Brazil caused widespread contamination in the Brazilian coast, posing risks to both animal and human health through seafood consumption. Therefore, this study aimed to evaluate seafood samples from different locations impacted by the oil spill. For this purpose, 44 samples underwent extraction processes for the determination of polycyclic aromatic hydrocarbons (PAH) and benzene, toluene, ethylbenzene, and xylene (BTEX). The BTEX compounds were undetected above the limit of detection (LOD) of 0.02 µg g-1 of wet mass. The LOD and limit of quantification (LOQ) for the PAH were 2 and 5 ng g-1, respectively. The range of recovery of PAH obtained from spiking was 39 ± 15.8 to 84 ± 5%. The concentration of PAH in the samples ranged from < LOQ to 17.5 ng g-1. Results suggested higher contamination levels in samples collected in Rio de Janeiro, with quantifications for 11 of the evaluated PAH. Benzo[a]pyrene and dibenzo[a,h]anthracene, both potentially carcinogenic, were found in 32 and 14% of samples, respectively. Therefore, additional coastal monitoring is advised to ensure seafood safety, given the potential PAH carcinogenicity, which could strain the Brazilian public health system.
Research on the launch dynamics characteristics of Gatling guns
Authors: Hao Kun Peng , Li Lei , Yang Guo Lai
Published: September 2024

The advantages of the Gatling gun, such as high firing rate, large interception range, and wide range of use, have made it an indispensable weapon system in the defense field. At present, the analysis of shooting vibration of the Gatling gun is a challenging key point in related research. In response to the lack of research on the shooting vibration characteristics of Gatling gun weapon systems, this paper carries out a numerical simulation study of the launch dynamic characteristics of the Gatling gun based on the nonlinear launch dynamics theory of artillery. The results of muzzle disturbance under continuous shooting conditions are obtained, and the shooting density of Gatling guns under different situations is analyzed and compared based on the method of shooting density calculation. This research fills the gap in the study of launch dynamics of Gatling weapons, providing design references and theoretical support for the overall design and performance verification of Gatling guns.
Design of treatment scheme and identification method of treatment effect for soft soil subgrade
Authors: Zhang Wen , Fan Chong , Lei Ming , Li Zhibin
Published: September 2024

According to the characteristics of the soft soil subgrade in the Haiou Island section of Nansha Bridge, a comprehensive geological survey and soil analysis were conducted. Based on the analysis results, a corresponding design scheme for the soft soil subgrade was formulated to ensure bridge safety and stability. Furthermore, various reinforcement measures such as compaction, drainage, and lightweight soil were implemented to mitigate the impact of soft soil filling on the bridge structure. To evaluate the effectiveness of our treatment method, post-construction effect testing was performed using both static pressure and vibration acceleration methods. The static pressure method provided crucial parameters related to bearing capacity and compressibility of the soft soil subgrade while vibration acceleration analysis reflected response characteristics under dynamic load conditions. By comparing and analyzing results obtained from these two methods comprehensively evaluated feasibility of our treatment approach. Finally, based on experimental study findings and data analysis outcomes, it is recommended that post-construction effect testing for Haiou Island section's soft soil subgrade should employ both static pressure method and vibration acceleration method along with targeted reinforcement measures selected specifically to minimize adverse impacts on bridge structure.
Performance improvement technology of sludge roadbed based on vibration slow release
Authors: Tang Sai , Xie Youchao , Long Xiaolin
Published: September 2024

In order to improve the anti-vibration properties and bearing capacity of solidified sludge, this article takes silt soil as the research object and selects sludge solidification materials with good solidification performance. The chemical element composition of muddy soil was analyzed using an energy dispersive X-ray spectrometer (EDS). The microstructure and characteristics of muddy soil and solidifying agent were characterized by transmission electron microscopy experiments (TEM). The optimal moisture content and maximum dry density of solidified sludge were analyzed using compaction tests. The unconfined compressive strength test was used to evaluate the bearing capacity and strength variation of solidified sludge. The vibration characteristics of sludge under different testing times and frequencies was studied. The research results indicate that the solidifying agent could reduce the moisture content of muddy soil significantly, improve the anti-vibration properties and bearing capacity of muddy soil effectively, which provide relevant basis for improving the performance and anti-vibration performance of solidified sludge used for roadbed filling. This study could provide innovative reference for the vibration and performance of solidified sludge used in roadbed filling.
Investigation of the propagation characteristics of train-induced vibration at Guangzhou Baiyun railway station
Authors: Xia Wei
Published: September 2024

In densely populated cities, the increasing popularity of railways and urban rail transit interchange hubs has led to the extensive use of land resources and raised concerns about the environment, especially the inevitable noise and vibration impact. This study aims to identify the propagation patterns of roof structure vibrations in railway complexes through experimental research, with the premise of maintaining normal train operation and safety, in order to lay a foundation for developing vibration mitigation strategies and optimizing functional layout. The results found that the train-induced vibrations are strongest at track level, but decrease as they move vertically and horizontally. Vibrations from passing trains are most noticeable within a single floor slab and beams, with minimal transmission at the base of columns.
Analysis and optimization of vibrating screen structure based on modal simulation
Authors: Li Ying , Yang Ran
Published: September 2024

In order to enhance the stability and reliability of the vibrating screen, modal and harmonic response characteristics were simulated and analyzed using the finite element method. The final assembly model was established in Creo, serving as an intermediate format for material definition and mesh accuracy verification. The analysis of natural frequency and mode revealed that the overall structural stiffness was basically satisfactory. However, harmonic response analysis indicated issues related to excessive stress and stress concentration within the structure. Subsequent optimization of the frame structure confirmed nearly unchanged low-order natural frequencies, while maximum stress was reduced by 22.15 %, holding significant implications for process cost control.
Research on dynamic characteristics of wind turbine’s transmission system considering gear tooth lubrication
Authors: Cao Li , Sun Wenlei , Gou Tao
Published: September 2024

To improve wind turbines’ reliability and lifespan, taking the two-stage fixed shaft gearbox of wind turbines as study object. The oil stiffness and meshing stiffness of the transmission system are calculated, and the composite stiffness is obtained with the consideration of lubricating film. Then analyzed the dynamic characteristics of wind turbines’ transmission system before and after consider the oil stiffness in different operating conditions. The findings indicate that after considering the gear lubrication effect, the composite stiffness gradually decreases as rotational speed increase; within a certain rotational speed range, the tooth-surface load can be reduced, making the system run more smoothly. Therefore, the presence of oil film and its impact on its stiffness cannot be ignored. This study has certain guiding significance in improving the transmission efficiency and reducing noise of wind turbines.
Development of gear fault identification of wind turbine’s transmission system based on VMD and FNN
Authors: Cao Li , Sun Wenlei
Published: September 2024

In order to improve the safety of wind turbine, this paper takes the high-speed spur gear on output shaft in the transmission system of the wind turbine as the study object. The original signals of the gear in different fault states which obtained from the experimental platform decompose by the empirical mode decomposition method (EMD) and the variational mode decomposition method (VMD), respectively. Then the different gear fault types’ eigenvectors were built. Fuzzy neural network (FNN) is adopted to learn the fault types and eigenvector samples of gears, and then the fault types of gears are identified. It is found that the fault features decomposed by VMD method have reached a high accurate recognition rate point to the fact that VMD has good applicability in the fault recognition of gear in wind turbine.
Determination of kinematic and dynamic characteristics of a reversible vibratory conveyor with an electromagnetic drive
Authors: Gurskyi Volodymyr , Korendiy Vitaliy , Krot Pavlo , Dyshev Oleksandr
Published: September 2024

The paper considers the design parameters that must be provided during the practical implementation of small-sized reversible vibratory conveyors with an electromagnetic drive. The proposed conveyor is developed on the basis of a classical two-mass oscillatory system. Two oscillating masses are connected by symmetrically assembled round-shaped rods. In order to avoid angular (torsional) oscillations of the vibratory conveyor, the geometrical centers of mass and stiffness of the spring system are aligned at the same point. The analysis of kinematic characteristics is performed by means of numerical solving of the system of nonlinear Lagrange-Maxwell differential equations. The influence of the phase shift angle between the electromagnetic excitation of horizontal and vertical oscillations on the trajectories of the mass center of the conveying member is analyzed. The first two frequencies and forms of natural oscillations of the vibratory conveyor are determined for estimating its dynamic characteristics. The novelty of this study lies in the development of a new design of a vibratory conveyor with a controllable independent electromagnetic drive that provides the conveying reversibility and efficiency.
Influence of the welding cycle on the parameters of material damageability of the high-strength steel connection with an austenitic seam
Authors: Dzyubyk Andriy , Kusyi Yaroslav , Dzyubyk Liudmyla , Nazar Ihor , Ivanov Vitalii
Published: September 2024

The distribution of macrohardness of the material of a welded joint made of high-strength steel in the vicinity of a weld with an austenitic structure has been studied. The characteristics of the material's homogeneity, technological damageability, and the intensity of its growth have been determined using the LM-hardness method. The obtained characteristics of the material are considered according to the distance from the axis of the weld. It is shown that using the dispersion of important physical and mechanical characteristics to analyze the material homogeneity makes it possible to consider the differences in relation to the base material, structure, and properties of the weld. The method used in the work to assess the material damageability can be used for a welded joint that is heterogeneous in material. The obtained results are applicable in developing the technique of heterogeneous weld joints made of high-strength steels, as well as in the study of existing welded critical structures of long-term operation, in particular, main pipelines.
Banano sostenible
Authors: Lizcano Julieth
Published: September 2024

Banano sostenible. Agronegocios en la zona bananera del Magdalena aborda la evolución de la Sostenibilidad Corporativa (SC) en el sector bananero del Magdalena, Colombia. El libro explora cómo las empresas bananeras de esta región han adoptado prácticas sostenibles para enfrentar los desafíos en la producción y comercialización internacional de banano en los albores del siglo XXI. El libro está basado en una investigación doctoral y utiliza un enfoque que combina entrevistas, estudios de caso y observación directa para mostrar cómo las Comercializadoras Internacionales (C.I.) de banano están integrando la sostenibilidad en sus operaciones diarias. El libro está organizado en seis capítulos que cubren desde la historia del banano en la región, pasando por su Cadena Global de Valor (CGV), hasta los Estándares de Sostenibilidad (ES) que se están implementando en la agroindustria bananera a nivel mundial. Este libro no solo proporciona una visión detallada y accesible para los lectores interesados en temas de sostenibilidad y agronegocios, sino que también ofrece recomendaciones prácticas para mejorar la gestión de los agronegocios implicados y la distribución del valor en los diferentes eslabones de la industria bananera. Este libro es una lectura esencial para cualquiera que quiera entender la importancia del banano en la economía y la sociedad de Colombia.
Exploring the Therapeutic Potential of Rutin in Psoriasis: Network Pharmacology and Experimental Validation
Authors: Li Xinyue , Han Yingying , Liang Xinghua , Hu Yuan , Lang Guangping
Published: September 2024

Objective:

This study aimed to investigate the potential therapeutic efficacy of rutin in
the management of psoriasis and elucidate its underlying molecular mechanisms.

Methods:

A systems biology approach, utilizing network pharmacology, was employed to identify
and analyze putative targets of rutin relevant to psoriasis. The impact of rutin on the Psoriasis
Area and Severity Index (PASI) scores was assessed in an imiquimod (IMQ)-induced murine
psoriasis model. Histopathological alterations in the skin lesions were examined using hematoxylin
and eosin (H&E) staining. Expression levels of key inflammatory mediators, including
Tnf, Hif1a, Ptgs2, Tlr4, Nfkb1, Mtor, and Il2, were quantified using quantitative real-time polymerase
chain reaction (qRT-PCR).

Results:

A comprehensive analysis revealed 62 potential targets of rutin in the context of psoriasis,
with these targets being part of 72 interconnected signaling pathways. In vivo studies demonstrated
a significant reduction in PASI scores in rutin-treated mice compared to those in the control
group. Additionally, rutin treatment was associated with marked improvements in skin lesions,
characterized by reduced crust formation and epidermal thickness. qRT-PCR analysis indicated
that rutin administration downregulated the mRNA expression of Tnf, Hif1a, Ptgs2, Tlr4,
Nfkb1, Mtor, and Il2 in the lesional skin.

Conclusion:

These findings suggest that rutin holds promise as a therapeutic agent for psoriasis,
as it effectively ameliorates IMQ-induced psoriasis-like skin inflammation in mice through
modulation of multiple signaling pathways and inflammatory mediators.
Targeting SARS-CoV-2-Induced Cardiovascular Injury: Exploring the Potential of Ponatinib in Mitigating Cardiovascular Necroptosis in COVID-19
Authors: Sotoudeheian Mohammad Javad , Azarbad Reza , Mirahmadi Seyed-Mohamad-Sadegh , Pirhayati Mohammad , Moradi Mohammad , Pazoki-Toroudi Hamidreza
Published: September 2024

The incidence of Coronavirus Disease 2019 (COVID-19) has increased dramatically
in recent years, affecting millions of people worldwide. The primary cause of morbidity and
mortality in COVID-19 patients is respiratory illness. However, the disease can also significantly
impact the cardiovascular system. SARS-CoV-2, the virus responsible for COVID-19, enters
cells using the angiotensin-converting enzyme 2 (ACE-2) receptor. ACE-2 is a component of the
renin-angiotensin system (RAS) and plays a crucial role in regulating various pathological processes.
The interaction of the virus with ACE-2 in the myocardium can lead to direct heart damage.
Several mechanisms may contribute to myocardial damage in COVID-19 patients, including
systemic inflammation, myocardial interstitial fibrosis, interferon-mediated immune response,
exaggerated cytokine response, T-cell-mediated damage, coronary plaque instability,
and hypoxia. There has been concern that ACE inhibitors (ACE-Is) and angiotensin receptor
blockers (ARBs) may increase vulnerability to SARS-CoV-2 by upregulating ACE-2 expression.
However, it may be advisable to continue medications for patients with underlying cardiovascular
disorders. The precise mechanisms of cardiomyocyte injury in COVID-19 are not fully
understood, but necroptosis appears to play a significant role. Current treatments for cardiac
damage in COVID-19 patients include IL-6 blockers and antiplatelet therapy. Ponatinib, a small
molecule tyrosine kinase inhibitor designed using computational and structural approaches, has
shown the potential to affect cell death through its impact on tyrosine kinase activity. By reviewing
studies related to ponatinib’s effects on necroptosis and cell death, we propose a novel approach
to potentially reduce the cardiotoxic effects of COVID-19 on cardiomyocytes. Further
research is needed to fully elucidate the mechanisms of cardiac injury in COVID-19 and to develop
targeted therapies to protect the heart from the devastating effects of this disease.
Utilization of Two Cross Two Switch for Bitonic Sorting Circuit
Authors: Bhattacharjee Subhasree , Sarkar Soumyadip , Das Kunal , Sadhu Arindam , Sarkar Bikramjit
Published: September 2024

Background:

The synthesis of reversible logic has gained prominence as a crucial research
area, particularly in the context of post-CMOS computing devices, notably quantum computing.

Objective:

To implement the bitonic sorting circuit, 2x2 switch, is used. The overarching objective
of implementing a reversible sorting circuit is to mitigate power consumption while promising secure
communication. The successful implementation of the bitonic sorting circuit utilizing the proposed
2x2 switch is validated through simulations conducted in IBM Qiskit.

Methods:

This study begins by employing the control swap gate to implement a 2x2 switch, aimed
at enabling concurrent computing operations within multiprocessor systems to enhance throughput.
Subsequently, following the successful implementation of the 2x2 switch, the study proceeds to design
a bitonic sorting circuit.

Results:

Bitonic sort using a 2x2 switch on the IBM Quantum Experience (IBMQ) platform via the
QISKit SDK in Python 3.6. Specifically, Qiskit v0.29.0 is utilized, with OpenQASM. OpenQASM
serves as the quantum assembly and instruction language.

Conclusion:

This work presents a methodology for constructing a 2x2 switch, utilizing a reversible
control swap gate as its core component. Additionally, it demonstrates the intricate development
and implementation of a bitonic sorting circuit, capitalizing on this innovative switch architecture.
Detection of Intrusions in Internet of Things Based Deep Auto Encoder Using Deepnets
Authors: Atlas LGodlin , Shiny KV , K P Arjun , N M Sreenarayanan , Nithiya J Lethisia
Published: September 2024

Aims and background:

As a communication paradigm that bridges the gap between virtual
and physical spaces, the Internet of Things (IoT) has quickly gained popularity in recent years.
In order to supplement the provisions made by security protocols, a network-based intrusion detection
system (IDS) has emerged as a standard component of network architecture. IDSs monitor and
detect cyber threats continuously throughout the network lifetime.

Objectives and Methods:

The main contribution is the development of a two-level neural network
model that optimizes the number of neurons and features in the hidden layers, achieving superior
accuracy in anomaly detection. Its include the utilization of deep anomaly detection (DAD) to protect
networks from unknown threats without requiring rule modifications. The research also emphasizes
the importance of feature extraction and selection, employing parallel deep models for
segmenting attacks. The proposed supervised technique enables simultaneous feature selection using
parallel models, enhancing the accuracy of IDS designs. A novel hybrid technique combining
Deep Auto Encoders (DAEs) and DeepNets is proposed for intrusion detection.

Results:

The research present a data preprocessing stage, converting symbolic and quantitative data
into real-valued vectors and normalizing them. Feature extraction involves utilizing DAEs to learn
concise representations of datasets. The deep network architecture, including multilayer perceptrons
and activation functions, is employed for feature extraction and classification. The proposed
approach utilizes a DeepNets in the final stage in order to improve the rate of 97% accurate outputs
and make it possible to achieve greatly accelerated execution durations.

Conclusion:

When measured against the performances of other approaches to the extraction of features,
the performance of the deep network platform is superior.
The Effect of High Flow Nasal Cannula (HFNC) on the Use of Ventilators in Severe to Critical COVID-19 Patients
Authors: Firdausintika Lavely Rakhmatan , Syafaah Irmi , Airlangga Prananda Surya , Kriswidyatomo Prihatma , Setiawan Herley Windo , Marhana Isnin Anang
Published: September 2024

Background:

Since the Coronavirus Disease 2019 (COVID-19) outbreak, clinicians have
been seeking alternative therapies to improve patient conditions due to limited ventilator availability.
The use of high-flow nasal cannula (HFNC) remains a debate regarding its potential to reduce intubation
rates or worsen patient conditions.

Objective:

The objective of this study was to analyze the effect of HFNC on ventilator usage in severe
to critical COVID-19 patients.

Methods:

This is an observational analytical study with a retrospective cohort design using medical
record data of patients with severe to critical COVID-19 at Airlangga University Hospital from
March, 2021 to August, 2021.

Results:

Out of 137 data, no significant relationship was found between the use of HFNC and ventilator
usage in severe to critical COVID-19 patients (p-value=0.337). The difference in oxygen therapy
has a significant impact on patient survival rates and duration of patient care (p-value=<0.001).

Conclusion:

This study included 137 research samples: 69 males and 68 females, with an average
age of 52.3 years, the majority presenting with diabetes and hypertension. Common symptoms included
dyspnea, cough, and fever. Physical examination showed an average heart rate (HR) of 104
bpm, median respiratory rate (RR) of 30 breaths/minute, median blood oxygen level (SpO2) of 86%,
average systolic blood pressure (SBP) of 138 mmHg, median diastolic blood pressure (DBP) of 80
mmHg, and median body temperature of 37.5 °C. The median duration of patient care in this study
was 8 days. No significant influence was reported between the use of HFNC and ventilator usage in
severe to critical COVID-19 patients. A significant impact of HFNC administration on patient survival
rates and duration of patient care was also reported.
EFEKTIVITAS INSEKTISIDA BERBAHAN AKTIF KLORFENAPIR + KLORANTRANILIPROL TERHADAP HAMA Plutella xylostella L. PADA TANAMAN KUBIS
Authors: Damayanti Afifah Indira , Rachmawati Rina
Published: September 2024

Kubis (Brassica oleracea L.) merupakan salah satu jenis tanaman hortikultura yang banyak dibudidayakan dan dikonsumsi oleh masyarakat Indonesia. Dalam proses budidaya dan pemeliharaan kubis, para petani sering mengalami kendala akan banyaknya serangan OPT seperti Plutella xylostella L. Bahan aktif insektisida yang sering digunakan oleh petani terhadap P. xylostella adalah klorfenapir dan klorantraniliprol. Penelitian ini bertujuan untuk mengetahui efektivitas insektisida berbahan aktif klorfenapir + klorantraniliprol pada beberapa konsentrasi terhadap hama P. xylostella dan musuh alaminya yaitu Diadegma semiclausum pada tanaman kubis. Kegiatan penelitian dilaksanakan di di Kecamatan Pujon, Kabupaten Malang dan Kecamatan Junrejo, Kota Batu, Jawa Timur sejak bulan Maret – Mei 2023. Penelitian ini menggunakan Rancangan Acak Kelompok (RAK) dengan 5 perlakuan yaitu klorfenapir + klorantraniliprol 1,00 ml/l; 0,75 ml/l; 0,50 ml/l; 0,25 ml/l; dan kontrol. Hasil dari penelitian menunjukkan bahwa penggunaan insektisida klorfenapir + klorantraniliprol dengan perbedaan konsentrasi memberikan pengaruh terhadap tingkat rerata populasi P. xylostella, intensitas serangan, dan hasil panen pada tanaman kubis. Perlakuan konsentrasi 1,00 ml/l baik di Kec. Pujon maupun Kec. Junrejo merupakan perlakuan terbaik karena efektif mengendalikan P. xylostella dengan nilai EI lebih dari 70%. Pengaruh penggunaan insektisida berbahan aktif klorfenapir + klorantraniliprol terhadap D. semiclausum masih belum diketahui.
KARAKTERISASI MORFOLOGI DAN ANATOMI DAUN CABAI RAWIT (Capsicum frutescens L.) YANG TERINFEKSI Cercospora capsici DI LOMBOK TIMUR
Authors: Mursyidin Abdul Halim , Mulyaningsih Tri
Published: September 2024

Cabai rawit adalah salah satu komoditas hortikultura yang banyak dibudidayakan secara komersial di Indonesia karena secara ekonomi dan konsumsi memiliki permintaan yang tinggi. Produksi tanaman cabai belum mampu memenuhi kebutuhan nasional. Serangan patogen merupakan salah satu faktor penghambat produksi cabai rawit di Indonesia. Tujuan dari penelitian ini adalah untuk mengarakterisasi kerusakan struktur morfologi dan anatomi daun cabai rawit yang terinfeksi jamur Cercospora capsici. Metode penelitian yang digunakan yaitu deskriptif observatif. Sampel daun cabai rawit yang menunjukkan gejala bercak kuning dikumpulkan dari lapangan, lalu diamati karakter morfologi dan anatominya. Hasil penelitian menunjukkan bahwa kerusakan karakter morfologi yaitu berupa bercak kecil bulat berwarna coklat dan klorosis dengan gejala lanjutan berupa nekrosis hingga terjadi kerontokan daun. Kerusakan karakter anatomi cabai rawit menunjukkan adanya infeksi hifa jamur yang masuk ke dalam jaringan mesofil dan korteks daun melalui stomata dan ruang antarsel sehingga menyebabkan terganggunya fotosintesis.
Revolutionizing Infrastructure Development: Exploring Cutting-Edge Advances in Civil Engineering Materials
Authors: Tiza Michael Toryila , Imoni Samson , Akande Ebenezer Ogırıma , Mogbo Onyebuchi , Jiya Victoria Hassana , Onuzulike Collins
Published: September 2024

This study addresses the evolving challenges in infrastructure development by exploring recent advancements in civil engineering materials. The problem lies in the limitations of traditional materials such as concrete and steel, which, while foundational, may not fully meet the demands of modern construction in terms of sustainability, durability, and resilience. The objective of this review is to assess the role and impact of both traditional and emerging materials, including supplementary cementitious materials, nanotechnology-based materials, and novel reinforcement options, on the performance and sustainability of infrastructure. The scope of the study includes an analysis of the performance characteristics, applications, and limitations of these materials. It also covers the integration of recycled materials, geopolymer-based composites, and biomimetic materials as viable, sustainable alternatives. The review further highlights the significance of functional materials for enhanced performance and energy efficiency and examines advancements in materials testing and evaluation techniques. The methodology involves a comprehensive literature review, synthesizing findings from recent studies to identify key trends, challenges, and research gaps in the field. Results indicate that these advanced materials contribute significantly to improving the sustainability, durability, and resilience of construction projects. However, the study also identifies existing research gaps, particularly in the long-term performance and large-scale application of these materials. The conclusion emphasizes the potential of these innovations to transform civil engineering by creating more robust, sustainable, and efficient infrastructure. Recommendations include continued research and development efforts to address identified knowledge gaps, fostering innovation, and adapting to the rapidly changing demands of the built environment.
The Relevance of Diet in Musculoskeletal Clinical Practice—A Narrative Review
Authors: Seels Ian , Field Rowena J.
Published: September 2024

Musculoskeletal (MSK) pain is a multifaceted problem, with many contributors. The assessment of these contributions by clinicians has evolved to include not only the musculoskeletal and nervous systems, but also psychosocial contributions. Nutrition, however, has not been considered as a potential contributor in the same way, despite a significant body of evidence showing that amending one’s diet may significantly reduce pain and inflammation. Historically, when the biomedical model was considered the gold standard for patient management, MSK medicine failed to adequately manage a significant cohort of patients, owing to potential psychosocial contributors to pain and disability being largely ignored. This review argues that clinicians may be making the same mistake with diet, failing to grasp the relevance of nutrition in MSK pain states. Clinicians should consider utilising a ‘nutritionally-informed’ approach for their patients, encouraging a reduction in ultra-processed foods and refined carbohydrates, whilst encouraging a focus on nutrient dense whole-foods.
Examining the Popularity, Content, and Intersections With the Substance Abuse and Mental Health Services Administration’s Definition of Recovery in a Nonclinical Online Cannabis Cessation Community: Infodemiology Study of Reddit Posts
Authors: Thulin Elyse J , Walton Maureen A , Bonar Erin E , Fernandez Anne
Published: September 2024

Background

Cannabis consumption has increased in recent years, as has cannabis use disorder. While researchers have explored public online community discussions of active cannabis use, less is known about the popularity and content of publicly available online communities intended to support cannabis cessation.

Objective

This study aims to examine the level of engagement and dominant content of an online community for cannabis cessation through 3 specific aims. First, we examine the use of a subreddit cannabis cessation community (r/leaves) over time to evaluate the popularity of this type of resource for individuals who want to stop using cannabis. Second, we examine the content of posts in the community to identify popular topics related to cessation. Third, we compare the thematic findings relative to the 4 domains of recovery defined by the Substance Abuse and Mental Health Services Administration (SAMHSA). By examining these 3 gaps, we take the initial steps toward understanding the experiences being shared online among individuals interested in cannabis cessation and compare them with the principles outlined in the SAMHSA definition of recovery.

Methods

Using the Pushshift application programming interface, we collected the count of posts by year between 2011 and 2021 and the narrative of the 100 posts with the most comments per year in a popular cannabis cessation–focused subreddit (r/leaves). A linear model and a nonlinear model were compared to evaluate change in the number of posts by year. Mixed natural language processing and qualitative analyses were applied to identify top terms, phrases, and themes present in posts over time. Overlap between themes and the 4 SAMHSA domains of recovery (health, purpose, community, and home) were examined.

Results

The number of annual posts in r/leaves increased from 420 in 2011 to 34,841 in 2021 (83-fold increase), with exponential growth since 2018. The term that was the most common across posts was “smoke” (2019 posts). Five major themes were identified, and a narrative arc was represented, from motivations and perceived benefits of cannabis use to the negative consequences of use, strategies to change behaviors, and the positive and negative consequences of change. There was substantial overlap between these 5 themes and 3 of SAMHSA’s 4 domains of recovery: health, purpose, and community. However, the domain of home was less commonly identified.

Conclusions

Engagement in this online cannabis support community appears to be increasing. Individuals using this forum discussed several topics, including multiple aspects of recovery defined by the SAMHSA. Online communities, such as this one may, serve as an important pathway for individuals seeking to reduce or cease their consumption of cannabis.