bluuebunny/crossref_metadata_2025 huggingface dataset:
Technicity and the Virtual
Authors: Hoel A. S. Aurora
Published: November 2022

This article outlines an eco-operational theory of technical mediation that centers on Gilbert Simondon’s notion of technicity. The argument is that technical apparatuses do the work of concepts. However, the eco-operational viewpoint completely alters the status of concepts: what they are, where they are, and what they do. Technicity, as understood here, concerns the efficacious action and operational functioning of a broad range of apparatuses (including living bodies and technical machines), which are conceived as adaptive mediators. The focus on technicity provides a new notion of the virtual, that of the operationally real, which resonates with Gilles Deleuze’s while also marking a new direction. What is more, by approaching mediation in terms of technicity, the eco-operational framework offers a novel understanding of concept or generality that stakes out a middle path between Kantian representational generality and Deleuzian concrete singularity.
Relative Deprivation Leads to the Endorsement of “Anti-Chicken Soup” in China
Authors: Zhang Xiaomeng , Wang Tianxin , Liu Zhenzhen , Sun Xiaomin , Yang Shuting
Published: November 2022

“Anti-chicken soup” (ACS) persuades people to yield to reality and give up rather than encouraging people to work hard as “chicken soup” does. The current study explored whether people with a higher level of relative deprivation (RD) would be more likely to endorse ACS. We found that people with high-measured (Study 1) and manipulated (Study 2) RD were more likely to endorse ACS. Study 2 also suggested that the effect was mediated by self-handicapping. It seems that relatively deprived individuals may adopt the strategy of self-handicapping so that they could attribute their failure to external causes, which in turn leads to lower motivation to try their best and ultimately the endorsement of ACS.
An Analysis of the Factors behind Rural Residents’ Satisfaction with Residential Waste Management in Jiangxi, China
Authors: Zhou Bo , Qi Fang , Riaz Muhammad Faraz , Ali Tariq
Published: November 2022

With the increasing environmental and health problems caused by residential solid waste (RSW), upgrading waste disposal services has become a key priority in rural areas of developing countries. Waste disposal services can be improved by incorporating the end-user evaluation of the services and the infrastructure. This study aims to analyze the respondents’ satisfaction with waste disposal services and infrastructure in rural China, which has not been well documented in the previous literature. For this purpose, we applied the ordered probit model on survey data of 1064 rural residents of Jiangxi, China. In two separate models, two independent variables, i.e., users’ ranking of waste disposal management services and waste disposal management infrastructure, were regressed on five sets of policy, personal, social and demographic, environmental, and village characteristics of the respondents. Our results show that rural residents have relatively high satisfaction (level four out of five) with RSW services. We found a significant correlation between all five investigated characteristics (personal, social and demographic, environmental, and village characteristics) and respondents’ satisfaction with RSW management. However, the correlation differs in magnitude and direction among different respondent groups, where gender, minority status, the sanitary condition of household toilets, and treatment of toilet waste at the village level have the largest influence on satisfaction. It was found that male respondents, ethnic minorities, residents with non-farming status, and respondents with more sanitary household toilets have higher satisfaction levels. Our results provide crucial references for decision-makers to effectively promote the further optimization and improvement of rural waste disposal systems in the future.
Bacterial Communities in Effluents Rich in Phenol and Their Potential in Bioremediation: Kinetic Modeling
Authors: Morones-Esquivel Miriam M. , Núñez-Núñez Cynthia M. , Hernández-Mendoza José L. , Proal-Nájera José B.
Published: November 2022

Phenol is used in the manufacturing process of phenolic resins from which residues remain that must be sent for confinement. For that reason, in this study, the wastewater of a resin factory was analyzed to isolate the bacteria present, identify them by molecular methods and finally evaluate their impact on bioremediation treatment. A total of 15 bacteria were isolated, of these, eight belong to the genus Bacillus spp. All bacteria were individually multiplied and inoculated in clusters in 15 L reactors which were carefully monitored for pH, electrical conductivity, chemical oxygen demand and temperature. The acquired data were analyzed using ANOVA with repeated measurements. The first test revealed that native bacterial communities reduce the phenol content by up to 20% and COD by 49%, which is significant with respect to the reactor not being inoculated with bacteria. Furthermore, when a mathematical model was applied to the reactors, it was shown that the bacteria require an adaptation time of approximately 100 h. A second test where the inoculation was interspersed with the addition of lime as a flocculant showed that, even though the reduction in phenol and COD was lower than in the previous test, the difference between treatments and control is statistically significant (α ≤ 0.05).
Effects of Grape Seed Extract Supplementation on Endothelial Function and Endurance Performance in Basketball Players
Authors: Nho Hosung , Kim Kyung-Ae
Published: November 2022

While dietary polyphenols supplements can improve endothelial function and blood flow to exercise, the effects of chronic supplementation with grape seed extract (GSE) containing a high dose of polyphenols on endurance performance are not known. Accordingly, in 12 elite athletes, we compared the effects of both GSE and placebo (PL) on submaximal VO2, time to exhaustion performance, and endothelial function during progressive cycling exercise for 14 days. Endothelial function was evaluated from the brachial artery via flow-mediated dilation (FMD). Compared to PL, GSE decreased submaximal VO2 at 80% and 120% of VO2peak and increased the time to exhaustion (p < 0.05). GSE also resulted in FMD-induced increase in brachial artery diameter (14.4 ± 5.2% vs. 17.6 ± 4.5%, p = 0.035). We demonstrated that chronic supplementation with GSE improved endurance performance and these effects may partially be due to vasodilation in active skeletal muscle mediated by enhanced endothelial function. Thus, our results suggest that GSE appears to be an ergogenic nutraceutical that can improve exercise performance in elite athletes.
Factors Influencing Marksmanship in Police Officers: A Narrative Review
Authors: Simas Vini , Schram Ben , Canetti Elisa F. D. , Maupin Danny , Orr Robin
Published: November 2022

Law enforcement officers routinely face unpredictable scenarios that may threaten the public, their colleagues, or themselves. In such situations, officers may be required to use firearms, with shooting accuracy becoming crucial. This literature review aimed to identify, synthesize, and report on research investigating factors that affect marksmanship in law enforcement personnel. A systematic search of seven databases was undertaken following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) approach. From an initial 5396 identified studies, 23 met the eligibility criteria. The key findings from these papers were: (1) physical exertion does not appear to decrease shooting performance, especially at close range (<10 m); (2) tactical load carriage does not appear to decrease shooting performance; in fact, it has been reported by officers as improving performance (likely due to training specificity); (3) the physical capability of officers may be of importance, notably grip strength, which the volume of evidence suggests is positively correlated with marksmanship; (4) anxiety imparted through high-stress scenarios negatively impacts shooting performance, but training under stress may counteract this factor, albeit for a short period. Together, these factors appear to have a trainability component where increased specific and realistic training can improve shooting accuracy, time, and precision, especially in high-stress situations.
Comparison of Kinematics and Electromyographic Activity in the Last Repetition during Different Repetition Maximums in the Bench Press Exercise
Authors: Larsen Stian , Haugen Markus , van den Tillaar Roland
Published: November 2022

The barbell bench press is often performed at different repetition maximums (RM). However, little is known about the last repetition of these repetition maximums in terms of movement kinematics and electromyographic activity in the bench press. This study compared kinematics and electromyographic activity during the last repetition of 1-RM, 3-RM, 6-RM, and 10-RM on the barbell bench press. Twelve healthy recreationally bench press-trained males (body mass: 84.3 ± 7.8 kg, age: 23.5 ± 2.6 years, height: 183.8 ± 4.2 cm) performed the bench press with a self-chosen grip width with four different repetition maximums. The participants bench pressed 96.5 ± 14.1, 88.5 ± 13.0, 81.5 ± 12.3, and 72.8 ± 10.5 kg with the 1-RM, 3-RM, 6-RM, and 10-RM. No differences were found between the bench press conditions in kinematic or electromyographic activity, except for the 10-RM, where a higher barbell velocity was observed at peak barbell deacceleration and first minimum barbell velocity (p ≤ 0.05) compared to the 1-RM and 3-RM. Overall, triceps medialis activity increased, whereas biceps brachii activity decreased from the pre-sticking to post-sticking region for all bench conditions (p ≤ 0.05). Since slower barbell velocity was observed in the sticking region for the 1-RM and 3-RM conditions compared to the 10-RM condition, we suggest training with these repetition maximums to learn how to grind through the sticking region due to the principle of specificity when the goal is to enhance maximal strength.
Traumatic Childbirth and Birth-Related Post-Traumatic Stress Disorder in the Time of the COVID-19 Pandemic: A Prospective Cohort Study
Authors: Benzakour Lamyae , Gayet-Ageron Angèle , Jubin Maria , Suardi Francesca , Pallud Chloé , Lombard Fanny-Blanche , Quagliarini Beatrice , Epiney Manuella
Published: November 2022

Background: Birth-related post-traumatic stress disorder occurs in 4.7% of mothers. No previous study focusing precisely on the stress factors related to the COVID-19 pandemic regarding this important public mental health issue has been conducted. However, the stress load brought about by the COVID-19 pandemic could have influenced this risk. Methods: We aimed to estimate the prevalence of traumatic childbirth and birth-related PTSD and to analyze the risk and protective factors involved, including the risk factors related to the COVID-19 pandemic. We conducted a prospective cohort study of women who delivered at the University Hospitals of Geneva between 25 January 2021 and 10 March 2022 with an assessment within 3 days of delivery and a clinical interview at one month post-partum. Results: Among the 254 participants included, 35 (21.1%, 95% CI: 15.1–28.1%) experienced a traumatic childbirth and 15 (9.1%, 95% CI: 5.2–14.6%) developed a birth-related PTSD at one month post-partum according to DSM-5. Known risk factors of birth-related PTSD such as antenatal depression, previous traumatic events, neonatal complications, peritraumatic distress and peritraumatic dissociation were confirmed. Among the factors related to COVID-19, only limited access to prenatal care increased the risk of birth-related PTSD. Conclusions: This study highlights the challenges of early mental health screening during the maternity stay when seeking to provide an early intervention and reduce the risk of developing birth-related PTSD. We found a modest influence of stress factors directly related to the COVID-19 pandemic on this risk.
Toxicity Assessment of Octachlorostyrene in Human Liver Carcinoma (HepG2) Cells
Authors: Ren Guofa , Wu Kangming , An Jing , Shang Yu , Zheng Kewen , Yu Zhiqiang
Published: November 2022

Octachlorostyrene (OCS) is a ubiquitous persistent organic pollutant; however, information regarding the toxicological effects of OCS remains limited. In this study, we studied the toxicity mechanisms of OCS using human liver carcinoma (HepG2) cells. The results showed that OCS reduced cell viability in a time- and dose-dependent manner. Compared with that in the control, the level of reactive oxygen species (ROS) was significantly increased in all treated HepG2 cells. We also found that (1) OCS induced damage in the HepG2 cells via the apoptotic signaling pathway, (2) OCS increased intracellular free Ca2+ concentration (>180%), and (3) following exposure to 80 μM OCS, there was an increase in mitochondrial transmembrane potential (MMP, ~174%), as well as a decrease in ATP levels (<78%). In conclusion, OCS is cytotoxic and can induce apoptosis, in which ROS and mitochondrial dysfunction play important roles; however, the observed increase in MMP appears to indicate that HepG2 is resistant to the toxicity induced by OCS.
Health Risks Associated with Informal Electronic Waste Recycling in Africa: A Systematic Review
Authors: Issah Ibrahim , Arko-Mensah John , Agyekum Thomas P. , Dwomoh Duah , Fobil Julius N.
Published: November 2022

Informal electronic waste (e-waste) recycling in Africa has become a major public health concern. This review examined studies that report on the association between e-waste exposure and adverse human health outcomes in Africa. The review was conducted following the updated version of the Preferred Items for Systematic Review and Meta-analysis (PRISMA 2020) statement checklist. We included papers that were original peer-reviewed epidemiological studies and conference papers, written in English, and reported on e-waste exposure among human populations and any health-related outcome in the context of Africa. Our results from the evaluation of 17 studies found an association between informal e-waste recycling methods and musculoskeletal disease (MSD) symptoms and physical injuries such as back pains, lacerations, eye problems, skin burns, and noise-induced hearing loss (NIHL). In addition, the generation and release of particulate matter (PM) of various sizes, and toxic and essential metals such as cadmium (Cd), lead (Pb), zinc (Zn), etc., during the recycling process are associated with adverse systemic intermediate health outcomes including cardiopulmonary function and DNA damage. This systematic review concludes that the methods used by e-waste recyclers in Africa expose them to increased risk of adverse health outcomes. However, there is a need for more rigorous research that moves past single pollutant analysis.
Numerical Analysis Method That Considers Weathering and Water-Softening Effects for the Slope Stability of Carbonaceous Mudstone
Authors: Fu Yeyang , Liu Zhaohui , Zeng Ling , Gao Qianfeng , Luo Jintao , Xiao Xinhui
Published: November 2022

The mechanical behavior of carbonaceous mudstone deteriorates greatly when exposed to wet environments, and the precise evaluation of its slope stability has been a difficulty. This study aims to establish a numerical analysis method for the instability problems of its slopes; this method considers the effects of weathering and water-softening by establishing their mathematical expressions. The weathering and water-softening effects are reflected by variations in the mechanical properties (e.g., elastic modulus, angle of internal friction, and cohesion) of carbonaceous mudstone, with the depth following a logistic function and the shear strength parameters varying with wetting duration and degree of saturation. Their weathering and water-softening effects are reproduced with the use of the ABAQUS finite-element software and MATLAB programming. The proposed numerical method is applied to analyze the seepage field and stability of a highway cut slope with and without protection structures; the application results show that the proposed numerical method is reliable in analyzing the slope’s instability problem. The use of the herringbone skeleton structures can reduce the water-softening effects and thus increase the safety factor of the slope. The findings of this study could provide guidance to the design and construction of highway cut slopes in mountain areas that are rich in carbonaceous mudstone.
Using Isovists in Measuring Surveillance and Expected Guardianship in Residential Neighborhood Property Crimes
Authors: Nubani Linda , Wineman Jean
Published: November 2022

Purpose: Assessing a level of surveillability, supervision, and expected guardianship in residential neighborhoods has been a topic of interest since the early work of Jacobs’ ‘eyes on the street’, and Newman’s ‘defensible space’. This paper reports on the use of isovists (two-dimensional polygons that represent the characteristics of the visual field) in understanding incidents of ‘breaking and entering’ in Ypsilanti, Michigan. Approach: Two measures relevant to environmental criminology were assessed: accessibility and surveillability. Findings: The findings indicate associations between incidents of crime and measures of visual accessibility. However, the level of homeownership was found to interact with the predictive models, suggesting the possible effect of ‘guardianship’. The geometrical shape of the isovist may also indicate where along a particular route, a crime is more likely to be committed. Originality: The results have the potential to assist law enforcement in identifying ‘hotspots’, and city planners in understanding the implications of urban design on crime.
Multi-Source Spatio-Temporal Data-Based Tourism Structure Analysis of Demonstration City for Global Tourism: Case Study of Liyang, China
Authors: Wu Haoqi , Chen Zhenan , Yan Jun , Tang Xiaolan
Published: November 2022

Tourism can bring economic development and social benefits to cities. At present, global tourism is the leading urban tourism development model in China, and there is a growing tendency to use global tourism demonstration cities as models for urban tourism development; however, existing research has mostly focused on the theoretical level, and it is unclear whether such cities achieve sustainable development on a realistic level. This study selected the first demonstration cities of global tourism in China and conducted a coupling analysis using multi-source big data, clustering algorithm models, regional tourism flow distribution characteristics, etc., to explore whether the model cities meet development requirements. The following findings can be drawn from the analysis results. Firstly, the clustering algorithm coupled model study can provide a more accurate assessment of the current situation of regional tourism compared to the thermal values; secondly, the selected cities did not meet the development requirements of sustainable tourism and are in urgent need of improvement. The overarching contribution of this study is to propose a quantitative and replicable framework for urban tourism evaluation, combining spatial big data, computer algorithmic models and urban economics, etc.; this study also extends the interpretation of global tourism cities, reminds scholars, urban planners and urban tourism managers not to underestimate the possible tourism-related unsustainability of global tourism cities, and provides theoretical support for future tourism construction and urban planning development in China.
Delineating Urban Community Life Circles for Large Chinese Cities Based on Mobile Phone Data and POI Data—The Case of Wuhan
Authors: Jiao Hongzan , Xiao Miaomiao
Published: November 2022

In the recent decade, a new concept, urban community life circle (CLC), has been introduced and widely applied to Chinese community planning and public service facilities configuration alongside people-oriented urbanization. How to delineate the CLC has become a core task of urban CLC planning. The traditional way to determine the CLC using administrative boundaries does not fully consider the needs of residents. Recent research on urban CLC delineation is usually based on residential behavior survey using sample surveys or GPS data. However, it is difficult to generalize the sample surveys or GPS surveys for one specific community to that for others, because of the extremely high cost. Due to the ubiquity of the location-based service (LBS) data, i.e., the mobile phone data and points of interest (POI) data, they can serve as a fine-grained and continuous proxy for conducting human daily activity research with easy accessibility and low cost. Mobile phone data can represent the daily travel activities of residents, and POI data can comprehensively describe the physical conditions. In this paper, we propose a method from both the social and physical perspectives to delineate the CLC based on mobile phone and POI data, named DMP for short. The proposed DMP method is applied to Wuhan. We decipher the CLC’s boundary and residents’ travel activity patterns and demonstrate that (1) the CLC is not a regular circle but a non-homogeneous corridor space extending along streets; and (2) adjacent CLCs are found to share some daily facilities. Based on these findings, we propose that CLC planning should be data-based and people-oriented in general. In addition, sufficient space in the overlapping region of the CLCs should be preserved for future planning of public service facilities configuration, given that adjacent CLCs share some daily facilities.
Impact of Methane and Hydrogen-Enriched Methane Pilot Injection on the Surface Temperature of a Scaled-Down Burner Nozzle Measured Using Phosphor Thermometry
Authors: Feuk Henrik , Pignatelli Francesco , Subash Arman , Bi Ruike , Szász Robert-Zoltán , Bai Xue-Song , Lörstad Daniel , Richter Mattias
Published: November 2022

The surface temperature of a burner nozzle using three different pilot hardware configurations was measured using lifetime phosphor thermometry with the ZnS:Ag phosphor in a gas turbine model combustor designed to mimic the Siemens DLE (Dry Low Emission) burner. The three pilot hardware configurations included a non-premixed pilot injection setup and two partially premixed pilot injections where one had a relatively higher degree of premixing. For each pilot hardware configuration, the combustor was operated with either methane or hydrogen-enriched methane (H2/CH4: 50/50 in volume %). The local heating from pilot flames was much more significant for hydrogen-enriched methane compared with pure methane due to the pilot flames being in general more closely attached to the pilot nozzles with hydrogen-enriched methane. For the methane fuel, the average surface temperature of the burner nozzle was approximately 40 K higher for the partially premixed pilot injection configuration with a lower degree of mixing as compared to the non-premixed pilot injection configuration. In contrast, with the hydrogen-enriched methane fuel, the differences in surface temperature between the different pilot injection hardware configurations were much smaller due to the close-to-nozzle frame structure.
Deep-Learning-Based Temporal Prediction for Mitigating Dynamic Inconsistency in Vehicular Live Loads on Roads and Bridges
Authors: Sinha Ananta , Chorzepa Mi G. , Yang Jidong J. , Kim Sung-Hee Sonny , Durham Stephan
Published: November 2022

Weigh-In-Motion (WIM) data have been collected by state departments of transportation (DOT) in the U.S. and are anticipated to grow as state DOTs expand the number of WIM sites in order to better manage transportation infrastructure and enhance mobility. Traditional approaches for monitoring the vehicle weight measured in WIM systems include conducting statistical tests between two datasets obtained from two calibration visits. Depending on the frequency of visits, these traditional approaches are ineffective or resource-demanding for identifying calibration needs. Excessive vehicle-weight drifts exceeding 10% are usually indicative of poor performance by WIM systems. However, it has been difficult to consistently monitor such performance due to the sheer amount of data. In Georgia, the number of WIM sites have expanded from 12 to 29 in the past 3 years. This paper proposes a deep-learning-based temporal prediction approach for modeling sequential data and monitoring the time-history of the live loads imposed on roads and bridges. In total, 29 WIM sites in Georgia are analyzed to examine the effectiveness of a proposed temporal prediction approach for evaluating observed live loads. This study finds that the Jensen–Shannon divergence method is more effective than statistical difference tests, particularly when screening for live load anomalies. It is concluded that a LSTM neural network is able to capture temporal dynamics underlying the sequential load patterns observed in the WIM data and serves as an effective model for consistently monitoring the performance of WIM systems over time.
Beyond Human Nutrition of Edible Insects: Health Benefits and Safety Aspects
Authors: Aguilar-Toalá José E. , Cruz-Monterrosa Rosy G. , Liceaga Andrea M.
Published: November 2022

Nowadays, edible insects are considered an outstanding source of nutrients, primarily because they contain high-quality protein, amino acids, and vitamins. Insects are considered a promising alternative protein source towards alleviating future global food shortage problems due to their production considered as being more sustainable by using less agricultural land and water, as well as releasing a smaller amount of greenhouse gas emissions. However, other important aspects to consider about the consumption of edible insects include their health benefits and some safety aspects, which has been relatively overlooked. In this sense, edible insects contain bioactive compounds that can provide diverse bioactivities, such as antioxidant, antihypertensive, anti-inflammatory, antimicrobial, and immunomodulatory with a positive impact on human health. On the other hand, edible insects are a nutrient-rich food that can provide a perfect growth medium for diverse microorganisms, as well as possess some anti-nutritive factors. These two main aspects could represent food safety concerns for consumers. In this context, recent scientific evidence indicates that preservation methods, mainly thermal treatments, utilized in the cooking or processing of edible insects decreased the microbial levels and anti-nutritive factors, which suggests that edible insects do not represent a critical biological risk to humans. Besides, edible insects could have a positive effect on gut microbiota, either by their pre-biotic effect or their antimicrobial activity towards pathogens. Thus, this review is focused on studies related to the health benefits of edible insects and their isolated components, as well as discussion about potential issues related to their microbial content and anti-nutritive factors; this review will provide a synopsis on whether edible insects may be considered safe for human consumption.
Sustainability of C-Reactive Protein Apheresis in Acute Myocardial Infarction—Results from a Supplementary Data Analysis of the Exploratory C-Reactive Protein in Acute Myocardial Infarction-1 Study
Authors: Skarabis Horst , Torzewski Jan , Ries Wolfgang , Heigl Franz , Garlichs Christoph D. , Kunze Rudolf , Sheriff Ahmed
Published: November 2022

In the multicenter, non-randomized, exploratory C-reactive protein (CRP) Apheresis in Myocardial Infarction (CAMI-1) study, CRP apheresis after ST-Elevation Myocardial Infarction (STEMI) significantly decreased blood CRP concentrations in humans. Cardiac damage was assessed by Cardiac Magnetic Resonance (CMR1) 3–9 d after onset of STEMI symptoms and quantified by myocardial infarct size (IS; %), left ventricular ejection fraction (LVEF; %), circumferential strain (CS) and longitudinal strain (LS). Compared with the control group (n = 34), cardiac damage was significantly lower in the apheresis group (n = 32). These findings suggested improved wound healing due to CRP apheresis already within few days after the STEMI event. In the current supplementary data analysis of CAMI-1, we have tested by a follow-up CMR (CMR2) after an average of 88 (65–177) d whether the effect of CRP apheresis is clinically maintained. After this time period, wound healing in STEMI is considered complete. Whereas patients with low CRP production and a CRP gradient cut off of <0.6 mg/L/h in the hours after STEMI (9 of 32 patients in the CRP apheresis group) did not significantly benefit from CRP apheresis in CMR2, patients with high CRP production and a CRP gradient cut off of >0.6 mg/L/h (23 of 32 patients in the CRP apheresis group) showed significant treatment benefit. In the latter patients, CMR2 revealed a lower IS (−5.4%; p = 0.05), a better LVEF (+6.4%; p = 0.03), and an improved CS (−6.1%; p = 0.005). No significant improvement, however, was observed for LS (−2.9%; p = 0.1). These data suggest a sustained positive effect of CRP apheresis on heart physiology in STEMI patients with high CRP production well beyond the period of its application. The data demonstrate the sustainability of the CRP removal from plasma which is associated with less scar tissue.
Long-Term Survival and Quality of Life in Non-Surgical Adult Patients Supported with Veno-Arterial Extracorporeal Oxygenation
Authors: Cankar Tomaž , Krepek Mihela , Kosmopoulos Marinos , Radšel Peter , Yannopoulos Demetris , Noc Marko , Goslar Tomaž
Published: November 2022

Background: The use of veno-arterial extracorporeal membrane oxygenation (VA ECMO) for hemodynamic support is on the rise. Not much is known about the impact of extracorporeal membrane oxygenation (ECMO) and its complications on long-term survival and quality of life. Methods: In this single-center, cross-sectional study, we evaluated the survival and quality of life in patients treated with VA ECMO between May 2009 and July 2019. Follow-up was conducted between November 2019 and January 2020. Results: Overall, 118 patients were evaluated in this study. Of the 37 patients who were alive at hospital discharge, 32 answered the EuroQol-5 dimensional—5-level questionnaire (EQ-5D-5L). For patients discharged alive from the hospital, mean survival was 8.1 years, 8.4 years for cardiogenic shock, and 5.0 years for patients with refractory cardiac arrest. EQ-5D-5L index value of ECMO survivors was not significantly different from the general age-matched population. Neurologic complications and major bleeding during index hospitalization limit long-term quality of life. Conclusions: Patients treated with VA ECMO have high in-hospital mortality, with extracorporeal membrane oxygenation cardio-pulmonary resuscitation patients being at higher risk of early death. However, once discharged from the hospital, most patients remain alive with a reasonable quality of life.
The Impact of Overweight and Obesity on Reduced-Port Laparoscopic Distal Gastrectomy for Gastric Cancer Patients: A Propensity Score Matching Analysis of a Single-Institution Data
Authors: Kim Ho-Goon , Kang Dong-Yeon , Kim Dong-Yi
Published: November 2022

This study aimed to investigate the short-term postoperative outcomes of reduced-port laparoscopic distal gastrectomy and demonstrate its safety and feasibility in overweight and obese patients with gastric cancer. The medical records of 211 patients who underwent reduced-port laparoscopic distal gastrectomy, between August 2014 and April 2020, were reviewed. After propensity score matching, they were divided into a non-overweight group (n = 68) and overweight group (n = 68). Operative details and short-term surgical outcomes were compared between two groups. Reduced-port laparoscopic distal gastrectomy in overweight group showed statistically longer operation time (200.59 vs. 208.68 min, p = 0.044), higher estimated bleeding volume (40.96 vs. 58.01 mL, p = 0.001), and lesser number of harvested lymph nodes (36.81 vs. 32.13, p = 0.039). However, no significant differences were found in hospital course and other surgical outcomes. There was no mortality in either group, and the postoperative morbidity rate was not significantly different (14.7% vs. 16.2%). In the subgroup analysis, overweight and obesity did not significantly affect postoperative complication rates (16.2% vs. 16.2%, p = 1). We demonstrated comparable short-term surgical outcomes of reduced-port laparoscopic distal gastrectomy between the two groups (p = 0.412~1). Reduced-port laparoscopic distal gastrectomy was safe in overweight and obese patients with gastric cancer.
Significance of Temporal Muscle Thickness in Chronic Subdural Hematoma
Authors: Dubinski Daniel , Won Sae-Yeon , Behmanesh Bedjan , Cantré Daniel , Mattes Isabell , Trnovec Svorad , Baumgarten Peter , Schuss Patrick , Freiman Thomas M. , Gessler Florian
Published: November 2022

Background: Reduced temporal muscle thickness (TMT) was verified as an independent negative prognostic parameter for outcome in brain tumor patients. Independent thereof, chronic subdural hematoma (CSDH) is a neurosurgical condition with high recurrence rates and unreliable risk models for poor outcome. Since sarcopenia was associated with poor outcome, we investigated the possible role of TMT and the clinical course of CSDH patients. Methods: This investigation is a single-center retrospective study on patients with CSDH. We analyzed the radiological and clinical data sets of 171 patients with surgically treated CSDH at a University Hospital from 2017 to 2020. Results: Our analysis showed a significant association between low-volume TMT and increased hematoma volume (p < 0.001), poor outcome at discharge (p < 0.001), and reduced performance status at 3 months (p < 0.002). Conclusion: TMT may represent an objective prognostic parameter and assist the identification of vulnerable CSDH patients.
Characteristics of Long COVID: Cases from the First to the Fifth Wave in Greater Tokyo, Japan
Authors: Hirahata Kouichi , Nawa Nobutoshi , Fujiwara Takeo
Published: November 2022

Purpose: Approximately 25–60% of COVID-19 patients develop long-term sequelae of the condition known as long COVID. This study aimed to examine sociodemographic and clinical characteristics of long COVID in Japan. Methods: The data of long COVID patients, defined as those who were symptomatic after 28 days from onset, were collected in an outpatient clinic in Tokyo, Japan between 6 January 2020 and 2 October 2021 (N = 1891). Information on age, sex, employment, infection waves, vaccination, impairment in activities of daily living, and symptoms were obtained from electronic medical records. We used linear regression to analyze the association of patients characteristics with performance status. Results: The mean number of days from onset was 77.6 (SD: 71.3). Female, those who had their work hours reduced, on leave, dismissed or retired or not working, were associated with lower performance status. Fatigue, depressive symptom, brain fog, dyspnea, palpitation, body pain, loss of appetite, fever—but not headache, insomnia, loss of smell, loss of taste, hair loss, or cough—were associated with the lower performance status. Conclusion: Sex and employment status were associated with lower performance status in long COVID patients. Studies are needed to elucidate the full picture of the characteristics of long COVID patients.
Linking Heart Health and Mental Wellbeing: Centering Indigenous Perspectives from across Canada
Authors: Field Shannon N. , Miles Rosalin M. , Warburton Darren E. R.
Published: November 2022

Indigenous peoples have thrived since time immemorial across North America; however, over the past three to four generations there has been a marked increase in health disparities amongst Indigenous peoples versus the general population. Heart disease and mental health issues have been well documented and appear to be interrelated within Indigenous peoples across Canada. However, Western medicine has yet to clearly identify the reasons for the increased prevalence of heart disease and mental health issues and their relationship. In this narrative review, we discuss how Indigenous perspectives of health and wholistic wellness may provide greater insight into the connection between heart disease and mental wellbeing within Indigenous peoples and communities across Canada. We argue that colonization (and its institutions, such as the Indian Residential School system) and a failure to include or acknowledge traditional Indigenous health and wellness practices and beliefs within Western medicine have accelerated these health disparities within Indigenous peoples. We summarize some of the many Indigenous cultural perspectives and wholistic approaches to heart health and mental wellbeing. Lastly, we provide recommendations that support and wholistic perspective and Indigenous peoples on their journey of heart health and mental wellbeing.
The Roles of Vitamins in Diabetic Retinopathy: A Narrative Review
Authors: Ruamviboonsuk Varis , Grzybowski Andrzej
Published: November 2022

There have been attempts to evaluate the roles of vitamins for the prevention or treatment of eye conditions, such as glaucoma, age-related macular degeneration, and diabetic retinopathy (DR). Regarding DR, two main groups of studies can be identified. The first group focuses on the association between serum levels of an individual vitamin and DR. Many studies have found that lower serum levels of vitamins, particularly vitamin D, are significantly associated with the development, or severity, of DR, while some studies have not supported this trend. The second group evaluates dietary vitamin intakes and DR. A small, randomized placebo-controlled trial did not show any benefit of vitamin E intake on improving the area of retinal hemorrhage or diabetic macular edema at 12 months. A pilot study of patients with mild-to-moderate non-proliferative DR received tablets of combined vitamins B6, B9, and B12 for 6 months and significant improvement in retinal sensitivity and retinal thickness resulted. Two large prospective cohorts showed that high dietary intake of vitamin B6, and fruit rich in vitamin C and E, could significantly lower the risk of DR by 50% after an eight-year follow-up. Properly designed, randomized controlled trials are needed to support the results.
Pathways of Angiogenic and Inflammatory Cytokines in Multiple Myeloma: Role in Plasma Cell Clonal Expansion and Drug Resistance
Authors: Melaccio Assunta , Reale Antonia , Saltarella Ilaria , Desantis Vanessa , Lamanuzzi Aurelia , Cicco Sebastiano , Frassanito Maria Antonia , Vacca Angelo , Ria Roberto
Published: November 2022

Multiple myeloma (MM) is the second most common hematological malignancy, and despite the introduction of innovative therapies, remains an incurable disease. Identifying early and minimally or non-invasive biomarkers for predicting clinical outcomes and therapeutic responses is an active field of investigation. Malignant plasma cells (PCs) reside in the bone marrow (BM) microenvironment (BMME) which comprises cells (e.g., tumour, immune, stromal cells), components of the extracellular matrix (ECM) and vesicular and non-vesicular (soluble) molecules, all factors that support PCs’ survival and proliferation. The interaction between PCs and BM stromal cells (BMSCs), a hallmark of MM progression, is based not only on intercellular interactions but also on autocrine and paracrine circuits mediated by soluble or vesicular components. In fact, PCs and BMSCs secrete various cytokines, including angiogenic cytokines, essential for the formation of specialized niches called “osteoblastic and vascular niches”, thus supporting neovascularization and bone disease, vital processes that modulate the pathophysiological PCs–BMME interactions, and ultimately promoting disease progression. Here, we aim to discuss the roles of cytokines and growth factors in pathogenetic pathways in MM and as prognostic and predictive biomarkers. We also discuss the potential of targeted drugs that simultaneously block PCs’ proliferation and survival, PCs–BMSCs interactions and BMSCs activity, which may represent the future goal of MM therapy.
Safety and Efficacy of Three Variants of Canaloplasty with Phacoemulsification to Treat Open-Angle Glaucoma and Cataract: 12-Month Follow-Up
Authors: Kicińska Aleksandra K. , Danielewska Monika E. , Rękas Marek
Published: November 2022

Background: A single-center prospective randomized observational study to compare three types of canaloplasty, i.e., ab externo (ABeC), minicanaloplasty (miniABeC) and ab interno, (ABiC) combined with cataract surgery in primary open-angle glaucoma (POAG) patients over 12 months. Methods: 48 POAG patients underwent one of three canaloplasty procedures: ABeC (16 eyes), miniABeC (16 eyes) or ABiC (16 eyes) or combined with phacoemulsification. Patients were assessed at baseline, at day 0–1–7 and at month 1–3–6–12. Successful treatment was defined as unmedicated IOP reduction ≥20%. Complete surgical success was defined as an IOP ≤ 15 mmHg without medications, and a qualified surgical success as IOP ≤ 15 mmHg with or without medications. Results: Pre-washout IOP median values (mmHg) were 17 (ABeC), 18 (miniABeC) and 17 (AbiC) and decreased at 12-month follow up postoperatively to 13 (p = 0.005), 13 (p = 0.004) and 14 (p = 0.008), respectively—successful treatment was achieved in approximately 100% of patients for ABeC and in 93.8% for both miniABeC and AbiC groups. Preoperatively, the median number of medications was 2.0 (range 1–3) (ABeC), 2.0 (1–3) (miniABeC) and 2.0 (0–4) (ABiC); 12-month post-operatively, all medications were withdrawn except in two patients (followed miniABeC and AbiC). Conclusions: The three variants of canaloplasty significantly reduced IOP and the number of medications in patients with mild to moderate POAG and gave no significant complications.
Cerebral Ischemic Lesions after Transcatheter Aortic Valve Implantation in Patients with Non-Calcific Aortic Stenosis
Authors: Liu Xianbao , Zhou Dao , Fan Jiaqi , Dai Hanyi , Zhu Gangjie , Chen Jun , Guo Yuchao , Yidilisi Abuduwufuer , Zhu Qifeng , He Yuxin , Wei Yanxia , Liu Qiong , Qi Xinrui , Wang Jian’an
Published: November 2022

Evidence for transcatheter aortic valve implantation (TAVI) is scarce among patients with non-calcific aortic stenosis, and it is not known whether aortic valve calcification is associated with new cerebral ischemic lesions (CILs) that are detected by diffusion-weighted magnetic resonance imaging. So, our study enrolled 328 patients who underwent transfemoral TAVI using a self-expanding valve between December 2016 and June 2021 from the TORCH registry (NCT02803294). A total of 34 patients were finally confirmed as non-calcific AS and the remaining 294 patients were included in the calcific AS group. Incidence of new CILs (70.6% vs. 85.7%, p = 0.022), number of lesions (2.0 vs. 3.0, p = 0.010), and lesions volume (105.0 mm3 vs. 200.0 mm3, p = 0.047) was significantly lower in the non-calcific AS group. However, the maximum and average lesion volumes were comparable between two groups. Non-calcific AS was associated with lower risk for developing new CILs by univariate logistic regression analysis [Odds ratio (OR): 0.040, 95% confident interval (CI): 0.18–0.90, p = 0.026] and multivariate analysis (OR: 0.031, 95% CI: 0.13–0.76, p = 0.010). In summary, non-calcific AS patients had a lower risk of developing new cerebral ischemic infarction after TAVI compared to calcific AS patients. However, new ischemic lesions were still found in over 70% of patients.
A Process-Based Model for Arctic Coastal Erosion Driven by Thermodenudation and Thermoabrasion Combined and including Nearshore Morphodynamics
Authors: Islam Mohammad Akhsanul , Lubbad Raed
Published: November 2022

Various models have recently been developed to describe Arctic coastal erosion. Current process-based models simulate multiple physical processes and combine them interactively to resemble the unique mechanism of Arctic coastal erosion. One limitation of such models is the difficulty of including hydrodynamic forces. The available coastal erosion models developed for warmer climates cannot be applied to Arctic coastal erosion, where permafrost is a significant environmental parameter. This paper explains a methodology that allows us to use the models designed for warmer climates to simulate Arctic coastal erosion. The open-source software XBeach is employed to simulate the waves, sediment transport and morphological changes. We developed different submodules for the processes unique to Arctic coasts, such as thawing–freezing, slumping, wave-cut niche, bluff failure, etc. The submodules are coupled with XBeach to enable concurrent simulation of the two mechanisms of Arctic coastal erosion, namely thermodenudation and thermoabrasion. Some of the model’s input parameters are calibrated using field measurements from the Arctic coast of Kara Sea, Russia. The model is then validated by another set of mutually exclusive field measurements under different morphological conditions from the study area. The sensitivity analysis of the model indicates that nearshore waves are an important driver of erosion, and the inclusion of nearshore hydrodynamics and sediment transport are essential for accurately modelling the erosion mechanism.
Simulation Study of the Transport Characteristics of the Ice Core in Ice Drilling with Air Reverse Circulation
Authors: Wang Mengke , He Wenbo , Cao Jine , Qi Bo , Chen Jingchao , Cao Pinlu
Published: November 2022

Ice core drilling with air reverse circulation is a promising technology that uses high-speed airflow to transport the ice core from the bottom of the hole along the central passage of the drill pipe to the surface. Understanding how the ice core moves through the pipe is crucial for this technology in order to calculate the pneumatic parameters. In this paper, experimental study and the CFD dynamic mesh technique are used to analyze the ice core transport process and flow field characteristics. In order to prove the correctness of the dynamic mesh technique, the simulation results were verified with the experimental results, and it was found that all the simulation data were in agreement with the experimental data trend, and the maximum error was less than 10%. According to the study, once the ice core’s velocity reaches its maximum throughout the transport process, it does not change. The ice core’s maximum velocity increases with the diameter ratio and decreases with the length-to-diameter ratio, while eccentricity has no impact on the maximum velocity. When the air velocity reaches 21 m/s, the diameter ratio for the ice core with a length-to-diameter ratio of 2 increases from 0.80 to 0.92, and the maximum velocity increases from 8.92 m/s to 17.45 m/s. Data fitting demonstrates that the equation Vmax=−1.04V0 + 1.04Va describes the relationship between the ice core’s maximum velocity, Vmax, and air velocity, Va. Finally, we obtain the ice core’s suspension velocity model using CFD simulation to calculate the suspension velocity, V0.
Bi-Photon Entangled Airy Beams through Unstable Oceanic Turbulence
Authors: Yang Donghui , Yu Zhou , Hu Zhengda , Wang Wenhai , Zhu Yun
Published: November 2022

Orbital angular momentum (OAM) carried by bi-photon entangled Airy beams in unstable oceanic turbulence is theoretically investigated. The analytical expression of the spatial coherence radius of a spherical wave in the unstable stratification oceanic turbulence is derived to obtain the relative detection probability of bi-photon entangled Airy beams. The relative detection probability of OAM carried by bi-photon entangled Airy beams acquires significant enhancements—up to 62% compared to the same measurement for the single photon system over a distance of 100 m. Lower-order bi-photon entangled Airy beams with larger wavelengths, and main ring radius are less affected by oceanic turbulence. A larger main ring radius also contributes to reducing the fluctuations in detection probability. Oceanic turbulence dominated by salinity fluctuations induces more adverse effects on the OAM, as well as a stronger strength of the turbulence.