bluuebunny/crossref_metadata_2025 huggingface dataset:
Modulation of DNA Damage Response by SAM and HD Domain Containing Deoxynucleoside Triphosphate Triphosphohydrolase (SAMHD1) Determines Prognosis and Treatment Efficacy in Different Solid Tumor Types
Authors: Felip Eudald , Gutierrez-Chamorro Lucia , Gómez-Plaza Maica , Garcia-Vidal Edurne , Romeo Margarita , Moran Teresa , Layos Laura , Pérez-Roca Laia , Riveira-Muñoz Eva , Clotet Bonaventura , Fernandez Pedro Luis , Mesía Ricard , Martínez-Cardús Anna , Ballana Ester , Margelí Mireia
Published: January 2022

SAMHD1 is a deoxynucleotide triphosphate (dNTP) triphosphohydrolase with important roles in the control of cell proliferation and apoptosis, either through the regulation of intracellular dNTPs levels or the modulation of the DNA damage response. However, SAMHD1 role in cancer evolution is still unknown. We performed the first in-depth study of SAMHD1 role in advanced solid tumors, by analyzing samples of 128 patients treated with chemotherapy agents based on platinum derivatives and/or antimetabolites and developing novel in vitro knock-out models to explore the mechanisms driving SAMHD1 function in cancer. Low or no expression of SAMHD1 was associated with a positive prognosis in breast, ovarian and non-small cell lung cancer (NSCLC) cancer patients. A predictive value was associated to low-SAMHD1 expression in NSCLC and ovarian patients treated with antimetabolites in combination with platinum derivatives. In vitro, SAMHD1 knock-out cells showed increased γ-H2AX and apoptosis suggesting that SAMHD1 depletion induces DNA damage leading to cell death. In vitro treatment with platinum-derived drugs significantly enhanced γ-H2AX and apoptotic markers expression in knock-out cells, indicating a synergic effect of SAMHD1 depletion and platinum-based treatment. SAMHD1 expression represents a new strong prognostic and predictive biomarker in solid tumors and thus, modulation of SAMHD1 function may constitute a promising target for the improvement of cancer therapy.
The Link between Tax Revenue Components and Economic Growth: Evidence from South Africa. An ARDL Approach
Authors: Pamba Dumisani
Published: January 2022

This study examined the link between tax revenue components and economic growth in South Africa, utilizing time series data for the period of 22 years. The stationarity of the variables was established using the Phillips-Perron (PP) unit root test, and the existence of long-run and short-run equilibrium conditions was tested using the Autoregressive Distributed Lag (ARDL) model. As a proxy for economic growth, the study used the real GDP growth rate as the dependent variable, with company income tax, personal income tax, taxes on international trade and transactions, taxes on income, profits, and capital gains tax, foreign direct investment, inflation, and gross savings as the independent variables. According to the PP findings, none of the variables are integrated at a higher order than one, i.e. (1). All variables are found to be cointegrated, and all explanatory variables have a long-run link with economic growth. According to the ARDL findings, company income tax, personal income tax, and taxes on international trade and transactions all have a positive long-run and short-run link with economic growth, whereas capital gain tax, foreign direct investment, and gross savings all have a negative long-run and short-run link with economic growth. The long-run coefficient is negatively related to RGDP, while the short-run coefficient revealed a positive link between inflation and economic growth, among other findings. Heteroskedasticity and autocorrelation are not present in our model, according to diagnostic tests. The CUSUM and CUSUMSQ values indicate that the model is structurally sound.
Nanomedicine Strategies for Management of Drug Resistance in Lung Cancer
Authors: Haider Mohamed , El Sherbeny Amr , Pittalà Valeria , Fallica Antonino N. , Alghamdi Maha Ali , Hussain Zahid , Khoder Ghalia , Greish Khaled
Published: January 2022

Lung cancer (LC) is one of the leading causes of cancer occurrence and mortality worldwide. Treatment of patients with advanced and metastatic LC presents a significant challenge as malignant cells use different mechanisms to resist chemotherapy. Drug resistance (DR) is a complex process that occurs due to a variety of genetic and acquired factors. Identifying the mechanisms underlying DR in LC patients and possible therapeutic alternatives for more efficient therapy is a central goal of LC research. Advances in nanotechnology resulted in the development of targeted and multifunctional nanoscale drug constructs. The possible modulation of the components of nanomedicine, their surface functionalization, and encapsulation of various active therapeutics provide promising tools to bypass crucial biological barriers. These attributes enhance the delivery of multiple therapeutic agents directly to the tumor microenvironment (TME), resulting in reversal of LC resistance to anticancer treatment. This review provides a broad framework for understanding the different molecular mechanisms of DR in lung cancer; presents novel nanomedicine therapeutics aimed to improve the efficacy of treatment of various forms of resistant LC; outlines current challenges in using nanotechnology for reversing DR; and discusses the future directions for clinical application of nanomedicine in management of LC resistance.
Ductility Estimation of Concrete Beams Longitudinally Reinforced with Hybrid FRP-Steel Bars
Authors: Thamrin Rendy , Zaidir Zaidir , Iwanda Devitasari
Published: January 2022

An experimental study was carried out to evaluate the ductility of reinforced concrete beams longitudinally reinforced with hybrid FRP-Steel bars. The specimens were fourteen reinforced concrete beams with and without hybrid reinforcement. The test variables were bars position, the ratio of longitudinal reinforcement, and the type of FRP bars. The beams were loaded up to failure using a four-point bending test. The performance of the tested beams was observed using the load-deflection curve obtained from the test. Numerical analysis using the fiber element model was used to examine the growth of neutral axis depth due to the effect of test variables. The neutral axis curves were then used to further estimate the neutral axis angle and neutral axis displacement index. The test results show that the position of the reinforcement greatly influences the flexural behavior of the beam with hybrid reinforcement. It was observed from the test that the flexural capacity of beams with hybrid reinforcement is 4% to 50% higher than that of the beams with conventional steel bars depending on bars position and the ratio of longitudinal reinforcement. The ductility decreases as the hybrid reinforcement ratio (Af/As) increases. This study also showed that a numerical model developed can predict the flexural behavior of beams with hybrid reinforcement with reasonable accuracy.
The Mediating Role of Resilience and Life Satisfaction in the Relationship between Stress and Burnout in Medical Students during the COVID-19 Pandemic
Authors: Duarte Ivone , Alves Ana , Coelho Ana , Ferreira Ana , Cabral Beatriz , Silva Bebiana , Peralta João , Silva Juliana , Domingues Pedro , Nunes Pedro , Serrão Carla , Santos Cristina
Published: January 2022

Following the WHO's declaration of a public health emergency due to the COVID-19 outbreak, the subsequent quarantine and confinement measures that were adopted, including distance learning measures, were shown to have caused a significant deterioration in the mental health of medical students. The goal of this study was to explore the mediating role of resilience and life satisfac-tion in the relationship between perceived stress and burnout among medical students in the con-text of COVID-19. A transversal assessment was performed using an online questionnaire, to which 462 students responded. The instruments applied were the Perceived Stress Scale-10, the Resilience Scale-25 items, the Satisfaction with Life Scale (SWLS) and the Burnout Scale (Olden-burg Inventory). A regression model was estimated for each dimension of burnout. The results revealed that resilience and life satisfaction play a mediating role in the association between stress and the dimensions of burnout. This suggests that measures of promoting mental health based on resilience and improving perceptions of life should be implemented.
ANALISIS KEMAMPUAN MEMBACA PEMAHAMAN DALAM PEMBELAJARAN BAHASA INDONESIA PADA SISWA KELAS V SD NEGERI 6 JATISARI KEDUNGREJA, KAB. CILACAP TAHUN PELAJARAN 2020/2021
Authors: Riani Nurulfat , Ngatman Ngatman , Suryandari Kartika Chrysti
Published: January 2022

Penelitian ini bertujuan untuk: 1) menganalis kemampuan membaca pemahaman dalam pembelajaran bahasa Indonesia siswa kelas V; (2) mendeskripsikan hambatan yang dialami siswa berkaitan kemampuan membaca pemahaman dalam pembelajaran bahasa Indonesia siswa. Penelitian ini merupakan penelitian kualitatif metode studi kasus dengan objek siswa kelas V yang berjumlah 25 siswa. Teknik pengumpulan data dalam penelitian ini meliputi observasi, tes kemampuan membaca pemahaman, wawancara, dan dokumen. Teknik analisis data pada penelitian ini yakni reduksi data, penyajian data, dan verifikasi. Hasil penelitian menunjukkan bahwa: (1) kemampuan membaca pemahaman siswa mencapai nilai rata-rata 79 yang termasuk dalam kategori tinggi. (2) hambatan yang dialami siswa dalam membaca pemahaman yakni pada soal kata tanya mengapa dan bagaimana, menentukan ide pokok paragraf, membedakan fakta dan opini, serta kegiatan belajar siswa yang kurang membiasakan diri untuk belajar memahami bahan bacaan. (3) upaya yang dilakukan guru yakni membiasakan literasi membaca pada awal pembelajaran, membiasakan siswa memahami bacaan dengan strategi yang tepat, serta memberikan bimbingan secara khusus bagi siswa yang mengalami hambatan. Kesimpulan penelitian ini adalah kemampuan membaca pemahaman dalam pembelajaran bahasa Indonesia siswa kelas V mencapai nilai rata-rata 79 yang termasuk dalam kategori tinggi berdasarkan Penilaian Acuan Patokan (PAP) sesuai KKM muatan pelajaran bahasa Indonesia yakni 68. Guru telah melakukan upaya dalam mengatasi hambatan-hambatan yang dialami siswa selama pembelajaran.
Pengaruh Kecerdasan Emosional terhadap Kemampuan Memecahkan Masalah Matematika Siswa Kelas IV SDN Se-Kecamatan Kebumen Tahun Ajaran 2020/2021
Authors: Rofiqoh Ngaenu , Rokhmaniyah Rokhmaniyah , Ngatman Ngatman
Published: January 2022

Abstrak

Penelitian ini bertujuan untuk mengetahui adanya pengaruh kecerdasan emosional terhadap kemampuan memecahkan masalah matematika dan menghitung besarnya sumbangan efektif kecerdasan emosional terhadap kemampuan memecahkan masalah matematika siswa kelas IV SDN se-Kecamatan Kebumen tahun ajaran 2020/2021. Penelitian ini merupakan penelitian kuantitatif dengan metode penelitian korelasi. Populasi dalam penelitian ini berjumlah 1.400 siswa dengan jumlah sampel 332 siswa kelas IV SDN se-Kecamatan Kebumen. Teknik pengumpulan data yang digunakan dalam penelitian ini adalah angket dan tes, data dianalisis menggunakan bantuan aplikasi SPSS versi 21. Hasil penelitian ini menunjukkan bahwa terdapat pengaruh kecerdasan emosional terhadap kemampuan memecahkan masalah matematika siswa kelas IV SDN se-Kecamatan Kebumen sebesar 13.2% dengan nilai Sig. 0,000 < 0,05, artinya semakin tinggi kecerdasan emosional siswa, maka akan semakin tinggi pula kemampuan memecahkan masalah matematika siswa, dan begitupun sebaliknya. Sumbangan efektif variabel kecerdasan emosional terhadap kemampuan memecahkan masalah matematika yaitu sebesar 13,2% dan sisanya sebesar 86,8% dipengaruhi oleh faktor lain.

Kata kunci: kecerdasan emosional, kemampuan memecahkan masalah matematika
PENGARUH DISIPLIN BELAJAR TERHADAP HASIL BELAJAR MATEMATIKA SISWA KELAS V SD NEGERI SEKECAMATAN KLIRONG TAHUN AJARAN 2020/2021
Authors: Lufianto Anang , Ngatman Ngatman , Salimi Moh
Published: January 2022

Disiplin belajar merupakan salah satu faktor yang dapat memengaruhi tinggi rendahnya hasil belajar matematika siswa. Penelitian ini bertujuan untuk mengetahui adanya pengaruh disiplin belajar terhadap hasil belajar matematika siswa kelas V di SDN se-Kecamatan Klirong Tahun Ajaran 2020/2021 dan mengetahui besarnya sumbangan efektif disiplin belajar terhadap hasil belajar matematika siswa kelas V di SDN se-Kecamatan Klirong Tahun Ajaran 2020/2021. Pengambilan sampel dilakukan dengan teknik cluster random sampling. Data dianalisis menggunakan bantuan aplikasi SPSS versi 21. Hasil penelitian ini menunjukkan bahwa terdapat pengaruh disiplin belajar terhadap hasil belajar matematika siswa kelas V SDN se-Kecamatan Klirong ditandai dengan nilai (r=.433; R2 = .187) dan nilai Sig. 0,000 < 0,05, yang artinya semakin tinggi disiplin belajar siswa, maka akan semakin tinggi pula hasil belajar matematika siswa, dan begitupun sebaliknya. Nilai sumbangan efektif variabel belajar terhadap hasil belajar matematika yaitu sebesar 13,10% dan sisanya sebesar 86,90% dipengaruhi oleh faktor lain.
HUBUNGAN ANTARA KEMANDIRIAN BELAJAR DENGAN HASIL BELAJAR IPA SISWA KELAS V SDN SEKECAMATAN KLIRONG TAHUN AJARAN 2020/2021
Authors: Kurnianto Rizki , Susiani Tri Saptuti , Chamdani Muhamad
Published: January 2022

Penelitian ini bertujuan untuk membuktikan adanya hubungan positif antara kemandirian belajar dengan hasil belajar IPA siswa kelas V SDN se-Kecamatan Klirong tahun ajaran 2020/2021 dan mengukur besarnya sumbangan kemandirian belajar terhadap hasil belajar IPA siswa kelas V SDN se-Kecamatan Klirong tahun ajaran 2020/2021. Penelitian ini merupakan penelitian kuantitatif dengan metode korelasi sederhana. Pengambilan sampel dilakukan dengan menggunakan teknik cluster random sampling. Analisis data menggunakan uji korelasi dengan taraf signifikansi 5% dan mencari sumbangan variabel dengan rumus koefisien determinasi. Hasil penelitian menunjukkan bahwa terdapat hubungan positif dan signifikan antara kemandirian belajar dengan hasil belajar IPA siswa kelas V SDN se-Kecamatan Klirong tahun ajaran 2020/2021. Koefisien korelasi yaitu sebesar 0,426 dan berarti berada pada tingkat hubungan sedang. Hal tersebut berarti semakin tinggi kemandirian belajar, maka akan semakin tinggi pula hasil belajar IPA siswa. Kemandirian belajar memberikan sumbangan sebesar 18,1% terhadap hasil belajar IPA.

Kata kunci: kemandirian belajar, hasil belajar IPA
PENGARUH PENDAMPINGAN BELAJAR ORANG TUA TERHADAP HASIL BELAJAR MATEMATIKA SISWA KELAS V SD NEGERI SEKECAMATAN BUAYAN KABUPATEN KEBUMEN TAHUN AJARAN 2020/2021
Authors: Aprilia Intan , Wahyudi Wahyudi , Hidayah Ratna
Published: January 2022

Abstract

The study aimed to determine the positive effect of parental assistance on mathematics learning outcomes to fifth grade students of public elementary schools in Buayan Sub-district in academic year of 2020/2021 and to measure the contribution of parental assistance on mathematics learning outcomes to fifth grade students of public elementary schools in Buayan Sub-district in academic year of 2020/2021. The research was a quantitative research with simple linear regression method. The samples were 306 fifth grade students in ten public elementary schools throughout Buayan Sub-district. Sampling method was probability sampling technique. The results showed that: (1) there was a positive and significant effect of parental assistance on mathematics learning outcomes to fifth grade students of public elementary schools in Buayan Sub-district and regression was 0.266; (2) the parental assistance contributed  26.6% on mathematics learning outcomes to fifth grade students of public elementary schools in Buayan Sub-district in academic year of 2020/2021 and the remaining 73.4% was influenced by other factors, such as: interests, talents, intelligence, attention, motivation, perseverance, school environment, and community environment.

Keywords: parental assistance, mathematics learning outcomes

 

Abstrak

Penelitian ini bertujuan untuk: (1) mengetahui adanya pengaruh positif pendampingan belajar orang tua terhadap hasil belajar matematika siswa kelas V SD Negeri se-Kecamatan  Buayan pada Tahun Ajaran 2020/2021; (2) mengetahui besarnya sumbangan pendampingan belajar orang tua terhadap hasil belajar matematika siswa kelas V SD Negeri se-Kecamatan Buayan pada Tahun Ajaran 2020/2021. Penelitian ini merupakan penelitian kuantitatif dengan metode regresi linier sederhana dengan sampel penelitiannya yaitu 306 siswa kelas V SD di sepuluh SDN Se-Kecamatan Buayan yang dipilih secara acak dengan teknik probability sampling. Hasil penelitian menunjukkan bahwa (1) terdapat pengaruh positif dan signifikan pendampingan belajar orang tua terhadap hasil belajar matematika siswa kelas V SDN se-Kecamatan Buayan dengan regresi sebesar 0,266; (2) sumbangan pendampingan belajar orang tua terhadap hasil belajar matematika siswa kelas V SDN se-Kecamatan Buayan tahun ajaran 2020/2021 sebesar 26,6% dan sisanya 73,4% dipengaruhi oleh faktor lain, seperti: minat, bakat, kecerdasan, perhatian, motivasi, ketekunan, lingkungan sekolah, dan lingkungan masyarakat.
Kata Kunci: Pendampingan Belajar, Hasil Belajar Matematika
PENGARUH POLA ASUH DAN GAYA BELAJAR TERHADAP HASIL BELAJAR IPA SISWA KELAS V SDN SEKECAMATAN PURING TAHUN AJARAN 2020/2021
Authors: Rahmawati Nita Eka , Suhartono Suhartono , Suryandari Kartika Chrysti
Published: January 2022

Pendidikan menjadi hal penting bagi kemajuan negara yang didasari pola asuh serta gaya belajar siswa. Lingkungan keluarga mendukung pendidikan siswa dari pola asuh yang diterapkan. Sedangkan kemampuan dalam diri siswa dilihat dari proses belajar melalui gaya belajarnya. Penelitian ini bertujuan untuk (1) menganalisis adanya pengaruh pola asuh terhadap hasil belajar IPA, (2) menganalisis adanya pengaruh gaya belajar terhadap hasil belajar IPA, (3) menganalisis adanya pengaruh pola asuh dan gaya belajar terhadap hasil belajr IPA. Penelitian ini merupakan penelitian kuantitatif dengan metode penelitian regresi berganda. Hasil penelitian menunjukkan (1) pola asuh berpengaruh positif terhadap hasil belajar IPA dengan korelasi sebesar 0.526 dan signifikansi 0,000, (2) gaya belajar berpengaruh positif terhadap hasil belajar sebesar 0,617 dengan signifikansi 0,000, dan (3) pola asuh dan gaya belajar memiliki pengaruh positif terhadap hasil belajar IPA sebesar 0,699 dengan signifikansi 0,000. Dengan demikian pola asuh dan gaya belajar memberikan pengaruh terhadap hasil belajar IPA.
Sikap Kepemimpinan Wirausahawan Millenial dalam Perspektif Chief Executive Officer (CEO) Millenial
Authors: Monalisa Monalisa , Akhyar Muhammad , Pelu Musa
Published: January 2022

Being a millennial entrepreneur who serves as a professional CEO, despite his young age as a millennial generation, there are several main approaches to leadership that need to be done by a millennial CEO that is seen from the point of view of millennial netizens. So how millennial entrepreneurs have a leadership attitude to become a millennial CEO who can increase professional value among relationships, customers and the wider community. The method used in this study is case studies with qualitative approaches. The type of data used is primary data through instagram social media surveys to see the activities of millennial entrepreneurs who reflect the leadership attitude of a millennial CEO. The sample of concern is CEO Indra Kesuma, a millennial entrepreneur from the field with his business instagram account kursustrading.id, action.kindness and others. And Esther Nathalia who became the CEO of millennials of my produktifkuy Instagram account. The results of the research findings are that millennial entrepreneurs with ceo positions in their businesses, have an advanced leadership attitude. Millennial CEOs are hardworking, resilient, responsible, and still care about the people below by helping and helping them both help in the form of money, open jobs and provide very useful knowledge through instagram content shared. In conclusion, although millennials are considered a vulnerable generation of despair, they show their own value through their leadership attitude in developing their entrepreneurship.
Eksplorasi Nilai-Nilai Asthabrata Sebagai Pendidikan Antikorupsi
Authors: Sari Rizki Rian
Published: January 2022

Penelitian ini bertujuan untuk mengetahui pendidikan antikorupsi berlandaskan nilai-nilai filosofi Astha brata. Metode yang digunakan dalam penelitian ini adalah metode kualitatif diskriptif. Sumber data diperoleh melalui studi kepustakaan. Nilai-nilai yang terkandung dalam Astha Brata menjadi pedoman dalam menyelenggarakan pendidikan antikorupsi. Salah satu tujuan pendidikan antikorupsi adalah menyiapkan pemimpin masa depan yang bebas dari tindakan korupsi. Nilai-nilai yang terkandung dalam Astha brata sebagai bentuk pengendalian diri bagi seorang pemimpin. Pemimpin yang tidak memiliki landasan yang kuat dalam diri maka akan mudah tergoda oleh materi yang berada disekitarnya. Seorang pemimpin tidak bisa dipisahkan dari materi. Dengan materi tersebut, tentu tidak semua menjadi haknya, jika tidak memiliki pengendalian diri yang kuat maka mudah sekali melakukan tindakan korupsi. Oleh karena itu, seorang pemimpin yang ideal diharapkan memiliki sifat dari delapan dewa dalam agama Hindu yang terdiri dari Indra Brata, Yama Brata, Surya Brata, Candra Brata, Bayu Brata, Kuwera Brata, Baruna Brata, dan Agni Brata. Di dalam nilai tersebut mengandung makna bagaimana menjadi pemimpin yang ideal yang bisa dicontoh.
Kontribusi Model Problem Based Learning terhadap Peningkatan Kemampuan Koneksi dan Pemecahan Masalah Matematik
Authors: Rustina Ratna , Anisa Witri Nur
Published: January 2022

Tujuan dari penelitian ini adalah untuk mengetahui peningkatan kemampuan koneksi dan pemecahan masalah matematik mahasiswa, mana yang lebih baik  antara yang mengikuti pembelajaran melalui model Problem Based Learning dengan yang mengikuti  pembelajaran konvensional, peningkatan kemampuan koneksi dan pemecahan masalah matematik mahasiswa, mana yang lebih baik pada  kelompok atas dan bawah antara yang mengikuti pembelajaran melalui model Problem Based Learning dengan yang mengikuti  pembelajaran konvensional. Populasi dalam penelitian ini adalah seluruh mahasiswa program studi pendidikan matematika Universitas Siliwangi angkatan 2014/2015, sedangkan untuk menentukan sampel dalam penelitian ini menggunakan teknik Purposive Random Sampling terpilih kelas 2014 E sebagai kelas eksperimen dan kelas 2014 D sebagai kelas kontrol. Instrumen yang digunakan dalam penelitian ini adalah soal tes kemampuan koneksi matematik dan soal tes kemampuan pemecahan masalah matematik. Hasil penelitian menunjukan bahwa 1) peningkatan kemampuan koneksi matematik mahasiswa yang mengikuti  pembelajaran melalui model Problem Based Learning lebih baik dengan yang mengikuti  pembelajaran konvensional, 2) peningkatan kemampuan pemecahan matematik mahasiswa yang mengikuti  pembelajaran melalui model Problem Based Learning lebih baik dengan yang mengikuti  pembelajaran konvensional, 3) terdapat perbedaan peningkatan kemampuan koneksi dan pemecahan masalah matematik mahasiswa kelompok atas dan bawah yang memperoleh pembelajaran melalui model Problem Based Learning dengan yang mengikuti  pembelajaran konvensional.
Pendekatan Scientific Berbantuan Geogebra untuk Meningkatkan Mathematical Problem Solving
Authors: Nurjamil Dedi , Kurniawan Dian
Published: January 2022

Penelitian yang berjudul â€œPendekatan Scientific berbantuan Geogebra Untuk Meningkatkan Mathematical Problem Solvingâ€, dilaksanakan di Program Studi Pendidikan Matematika, Fakultas Keguruan dan Ilmu Pendidikan, Universitas Siliwangi Tasikmalaya dalam Mata Kuliah Kalkulus 1. Penelitian ini dilakukan dalam rangka menindaklanjuti hasil penelitian sebelumnya yang peneliti lakukan di program studi Pendidikan Matematika mengenai gaya belajar. Penelitian yang penulis lakukan mengenai pembelajaran menggunakan  pendekatan scientific dengan berbantuan software geogebra pada mata kuliah Kalkulus 1. Penelitian ini menggunakan Mix Method dengan sampel terdiri dari 2 kelas, kelas eksperimen 1 menggunakan pendekatan scientific berbantuan geogebra dan kelas eksperimen 2 menggunakan pendekatan scientific tidak berbantuan software geogebra. Instrumen yang digunakan Soal Tes Mathematical Problem Solving, Lembar Observasi, dan Software Geogebra. Hasil Postest menunjukkan peningkatan gain ternormalisasi kelas eksperimen 1 lebih baik kelas eksperimen 2. Hasil penelitian ini menghasilkan luaran yang berupa buku ajar yang digunakan dan jurnal yang dipublikasikan.
Complex Total Hip Arthroplasty in a Patient with Klippel-Trénaunay Syndrome
Authors: Morrison Todd A. , Streufert Benjamin D. , Engel Corey C. , Bernasek Thomas L. , Gill Meera
Published: January 2022

Case:

Klippel-Trénaunay syndrome (KTS) carries manifestations including skeletal dysplasia and prominent vascular malformations. This report details a case of hip dysplasia in the setting of KTS treated with total hip arthroplasty (THA) requiring preoperative embolization, intraoperative angiography for placement of an iliac artery occlusive balloon, and modular hip arthroplasty components for femoral and acetabular dysplasia. Perioperatively, the patient rehabilitated well and was walking painlessly and unassisted at 3 and 12 months postoperatively.

Conclusion:

Successful THA for dysplasia and degenerative changes associated with KTS is possible but requires a complex multidisciplinary perioperative approach.
A 180° Spin of the Femoral Component in Unicompartmental Knee Arthroplasty
Authors: Bouché Pierre-Alban , Ehkirch François-Paul
Published: January 2022

Case:

We report 2 cases of undescribed lateral unicompartmental knee arthroplasty failure: a 180° rotation of the femoral component. The patients experienced a locking event several years after arthroplasty, and radiographs revealed a perfect 180° rotation of the implant. Each patient underwent revision surgery to a total knee arthroplasty. At the 13-year follow-up, the first patient had no pain and a range of motion of 140°. The second patient, at 3 months, could walk without crutches with a flexion at 145°.

Conclusion:

Excessive laxity, coronal or sagittal, might be associated with this complication.
Antibiotic Therapy in 2-Stage Revision for Periprosthetic Joint Infection
Authors: Kurapatti Mark , Oakley Christian , Singh Vivek , Aggarwal Vinay K.
Published: January 2022

Background:

Patients undergoing total joint arthroplasty (TJA) are at risk for developing periprosthetic joint infection (PJI). To treat PJI, orthopaedic surgeons can perform 1-stage or 2-stage revision arthroplasty. Although 2-stage revision yields superior long-term outcomes, the optimal antibiotic therapy duration and route of administration between stages remain uncertain. In this systematic review, we aimed to identify if variations in antibiotic therapy, duration, and administration during 2-stage hip or knee revision arthroplasty affect PJI eradication rates and surgical outcome measures.

Methods:

A literature search was performed using the PubMed and Google Scholar databases to identify all original reports from January 2000 to June 2021 involving 2-stage revision arthroplasty to treat PJI. Studies were included if they specified antibiotic duration, an intravenous (IV) route of antibiotic administration, type of antibiotic, and 2-stage revision PJI eradication rate and had a mean or median follow-up of at least 2 years after the second-stage operation. Included studies were classified into 3 groups based on the length of IV antibiotic therapy after prosthesis explantation: prolonged IV antibiotic therapy of 4 to 6 weeks, shortened IV antibiotic therapy of ≤2 weeks, and shortened course of IV antibiotic therapy followed by 6 to 12 weeks of oral antibiotics.

Results:

Nine studies were included. Three studies utilizing a prolonged IV antibiotic therapy had PJI eradication rates of 79% to 96%. Four studies using a shortened IV antibiotic therapy showed PJI eradication rates of 88% to 100%. Finally, 2 studies utilizing a shortened course of IV antibiotic therapy with oral antibiotics had PJI eradication rates of 95% and 97%. There was no significant difference in eradication rates across IV antibiotic duration strategies, despite a diverse array of cultured microorganisms across the studies.

Conclusions:

Although the numbers are small, this systematic review suggests that prolonged IV antibiotic duration, shortened IV antibiotic duration, and shortened IV antibiotic duration supplemented with oral antibiotics confer similar PJI eradication rates after hip or knee arthroplasty.

Level of Evidence:

Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
TO PIN POINT THE FLAWS IN TUBERCULOSIS TREATMENT THAT LEADS TO MDR-TB IN NISHTAR HOSPITAL MULTAN; PAKISTAN
Authors:   Abdul Majeed, Ali Sindhu Mohsin
Published: January 2022

Tuberculosis is one of the major problems in developing countries. Can be treated but due to poor management of MDR-TB and multi-emerging now days. Nishtar Hospital Multan is one of the largest hospitals in South Asia. The purpose of this study was to point out the flaws in the case of treatment of tuberculosis, directly observed therapy and patient compliance, and tuberculosis. The study was conducted by researchers who have been associated with doctors and participants in the search, and when he visited the behavior in the hospital. And summarizes the data through the use of statistical data.
HYPOGLYCEMIC EFFECT OF ANDROGRAPHIS ECHIOIDES ON STREPTOZOTOCIN INDUCED EXPERIMENTAL RATS
Authors:   Kunchu Kavitha, Rupeshkumar Mani
Published: January 2022

The present study aims to study the hypoglycemic effect of methanol extract of Andrographisechioides (MEAE) in streptozotocin (STZ)-induced diabetic Wistar rats. Hyperglycemia was induced in rats by single intraperitoneal injection of STZ (55 mg/kg bodyweight). Three days after STZ induction, the hyperglycemic rats were treated with MEAE orally at the doses of 200, 500, and 800 mg/kg body weight daily for 21 days. Glibenclamide (1 mg/kg, orally) was used as reference drug. The fasting blood glucose levels were measured on each 7th day during the 21 days of treatment.
OVERVIEW OF GLYCEMIC CONTROL, KNOWLEDGE, AWARENESS AND ATTITUDE AMONG TYPE-2 DIABETES MALE PATIENT'S
Authors:   V.V. Venkatachalam, Abdulla Khan Noohu
Published: January 2022

Knowledge, awareness is the greatest weapon in the fight against diabetes mellitus. It can help the people understand the risk of diabetes, motivate them to seek proper treatment and care, and prepare them to keep the disease under control.
FREE RADICAL SCAVENGING ACTIVITY OF SIX MEDICINAL PLANTS OF BANGLADESH: A POTENTIAL SOURCE OF NATURAL ANTIOXIDANT
Authors:   Jahidul Islam, Hossain Shakhawat
Published: January 2022

The crude meoh extracts of six medicinal plants of bangladesh (ipomoea paniculata, withaniasomnifera, mikaniacordata, abromaaugusta, bombaxceiba, and oxalis corniculata) were screened for primary types of phytochemicals presence and in-vitro anti-oxidant activity by using the 1,1-diphenyl-2-picryldydrazyl-hydrate (dpph) free radical scavenging assay. Of all of them, the meoh extracts of the leaves of withaniasomnifera and oxalis corniculata showed strong antioxidant activity (ic50:27.8 and 19.98ï­g/ml), while the meoh extracts of ipomoea paniculata, abromaaugusta and bombaxceiba showed moderate activity (ic50: 86.48, 101.4 and 58.6 ï­g/ml, respectively).
La mediación intercultural y el papel de los menores migrantes en la comunicación en un centro de menores
Authors: Torres Aragón Raquel , Vargas-Urpí Mireia
Published: January 2022

La llegada de menores migrantes al sur de España lleva en crecimiento desde hace años. Asimismo, desde hace ya algunas décadas, se recurre a la mediación intercultural (MI) para dar respuesta a las necesidades de comunicación en la sociedad. Sin embargo, la precariedad y falta de reconocimiento de esta profesión conllevan la aparición de formas no profesionales, como es el caso de la intermediación lingüística por parte de menores (ILM). Este estudio de caso se centra en las dos formas de comunicación mediada que conviven en un centro de protección de menores de la provincia de Cádiz, perteneciente a la Junta de Andalucía, a saber: la MI y la ILM. Los objetivos principales son (a) dar a conocer la práctica de la ILM realizada por menores migrantes acogidos en dicho centro y observar cómo afecta a estos menores, y (b) hacer una comparativa con el servicio de MI. Para alcanzar estos objetivos se presentará en primer lugar el contexto en el que se sitúa este estudio: la inmigración de menores no acompañados y la realidad de los centros de acogida. A continuación se expondrán las figuras profesionales y las no profesionales que intervienen en este caso. La parte práctica del trabajo se basa en los datos recogidos mediante una entrevista al mediador actual y un cuestionario distribuido a las educadoras sociales del centro. En las conclusiones se expondrán los resultados de la parte práctica contrastados, como puede ser la particularidad que supone la ILM enmarcada en un centro de protección de menores migrantes.
Traducción y medios de comunicación al trasluz de la homonormatividad
Authors: Martínez Pleguezuelos Antonio Jesús
Published: January 2022

En esta investigación nos aproximamos al concepto de «homonormatividad» y a la configuración de un discurso hegemónico sobre el colectivo LGTB+ desde occidente que oculta subrepticiamente a minorías dentro de esta comunidad. Desde estas premisas, examinaremos los discursos traducidos que circulan en los medios de comunicación para entender cómo actúa la homonormatividad y cómo permea la sociedad mediante la reproducción de sus dictámenes en el mundo globalizado actual a través de la traducción. Localizar las formas discursivas disimuladas de neoimperialismo en las diferentes vías de comunicación transnacional resultará vital, como veremos, para entender el carácter problemático e inestable de una identidad mutable configurada conforme a las fuerzas y presiones del poder dominante y, además, para descubrir la participación del traductor como agente que puede contribuir a desarmar el perfil normativo LGTB+ hegemónico en la actualidad.
La receta de cocina como recurso didáctico en la clase de traducción directa de la segunda lengua extranjera alemán
Authors: Toda Castán Claudia
Published: January 2022

Las recetas de cocina suelen aparecer en las asignaturas introductorias de traducción general, probablemente por considerarse un tipo textual de fácil abordaje para los estudiantes que se inician en esta práctica. Este artículo presenta de manera organizada y sistemática el aprovechamiento didáctico que puede extraerse de las recetas y que ya han ido señalando distintos investigadores y formadores. Además, ofrece el resultado de una experiencia de su uso en el aula como tipo de texto introductorio en un curso de iniciación a la traducción entre el par de lenguas alemán-español, en el que el alemán supone la segunda lengua extranjera del alumnado.
BATCHELOR, Kathryn. Translation and paratexts. Translations theories explored series editor: Theo Hermans. London, New York: Routledge, 2018, 201 pp., ISBN 978-0-8153-4922-8
Authors: Trigueros de la Fuente Mirian Soledad
Published: January 2022

Kathryn Batchelor aborda en esta publicación el concepto de paratexto que propuso Genette en profundidad, extrapolando el concepto de forma exhaustiva  a campos y disciplinas de forma novedosa que contemplan las peculiaridades de la era digital o aspectos controvertidos como la categorización paratextual que proponía Genette que no se ha rebatido. En líneas generales, Kathryn Batchelor da respuesta a preguntas interesantes como la pertinencia de la adecuación del concepto de paratexto hoy en día, estudio el ámbito de aplicación de los paratextos, las funciones o características que conllevan asociadas los paratextos, los criterios y funciones a los que se deben prestar atención para formar un corpus de estudio paratextual, o si es factible aplicar el estudio de la paratextualidad a la traducción y a los medios de masas de comunicación en la era digital o qué matices hay que introducir para validar este concepto. Batchelor abre las puertas un viaje complejo explicando una problemática compleja con claridad práctica, de forma fundamentada, multidisciplinar, sistemática y concisa, introduciendo matices que permiten  traspasar umbrales que facilitan la investigación a la vez que permiten ampliar el campo de investigación a través de un diálogo interdisciplinar. De modo magistral, la autora consigue acercar y simplificar un tema interesante que enriquece y complementa desde el rigor.
Formation Pressure Inversion Method Based on Multisource Information
Authors: Zhang Zhi , Sun Baojiang , Wang Zhiyuan , Pan Shaowei , Lou Wenqiang , Sun Dalin
Published: January 2022

The exploration and development of offshore oil and gas have greatly alleviated the tension of global oil and gas resources. However, the abnormal pressure of offshore reservoirs is more common compared with terrestrial oil and gas reservoirs, and the marine geological structure is complex, with the development of faults, fractures, and high and steep structures, which leads to the strong anisotropy of formation pore pressure distribution and uncertainty of pressure system change. In this paper, considering the corresponding characteristics of the randomness of the formation pressure prediction results in the Eaton equation for their respective variables, a formation pressure inversion method based on multisource information, such as predrilling data, bottomhole while drilling data, seabed measured data, and surface measured data, is established. On this basis, combined with the data of a well in the South China Sea, the variation law of the uncertainty of formation pressure prediction results under the conditions of predrilling data, measurement while drilling (MWD) data, and their mutual coupling is analyzed. The simulation results show that the uncertainty distribution of formation pressure prediction based solely on predrilling data shows linear accumulation trend with well depth, and the formation pressure inversion method based on multisource information can significantly curb the increasing trend of uncertainty when MWD data are introduced. Therefore, through the analysis of typical change patterns of monitoring parameters under normal/abnormal conditions during drilling, combined with the method of multisource information, the abnormal pressure information can be accurately predicted and inversed, which provides important support for wellbore pressure regulation under complex formation conditions.
DFT and TD-DFT Studies of 1,3,5-Tris (Dipheny1amino) Benzene Derivatives Based Hole Transport Materials: Application for Perovskite Solar Cells
Authors: babu nambury surendra , Riwa Irene Octavian
Published: January 2022

The current study examined a series of 1,3,5-tris (diphenylamino) benzene derivatives used as hole transport materials in perovskite solar cells (HTM1-HTM9). DFT and TD/DFT with the B3LYP/6-311G basis set used for all calculations. The ground state geometry, frontier molecular orbital (FMO), photoelectric properties and reorganization energies and the absorption spectra were investigated. The energy levels of HOMO and LUMO orbitals were calculated for HTM1-HTM9, compared to all of the compounds under investigation and the spiro-OMeTAD, HTM 8 has the lowest HOMO energy level, indicating a favourable overlap with the MAPbI3 perovskite active layer.
The Reconvictions of Mentally Disordered Offenders - How, When, and Where?
Authors: Noland Ebba , Strandh Mattias , Logan Fia Klötz
Published: January 2022

Background
Little is known about the recidivism of mentally disordered offenders after discharge from forensic psychiatric services. This is problematic because such knowledge could (i) help professionals who come into contact with this group to better plan interventions to prevent recidivism and (ii) clarify the effectiveness of forensic psychiatric care. The aim of this study was to investigate the new crimes of mentally disordered offenders who had been reconvicted after discharge from forensic psychiatric care.
Methods
Included in this study were all individuals who had been discharged from forensic psychiatric care in Sweden during 2009-2018, were included in the Swedish National Forensic Psychiatric Register, and had been reconvicted in a criminal court within the follow-up period of 2009-2018 (n=157). Retrospective registry data along with coded data from criminal judgments (n=210) were used to create a database. Descriptive statistical analysis was performed.
Results
75% of included individuals were reconvicted for at least one violent crime, but only 9 individuals were reconvicted for a serious violent crime, which can be compared to the 44 individuals with serious violent index crimes. The most common crime was “Other violent”. The most common sentence was probation. The offender’s most common relationship to the victim was having no known relationship, followed by the victim being a person of authority. The most common circumstance of the crime leading to the reconviction was that it occurred without apparent provocation; other common circumstances were related to the exercise of public authority. The most common crime scene was a public place.
Conclusions
Even though the reconvictions of this group included many violent crimes, there were very few serious violent crimes. The finding that the victims of the crimes of mentally disordered offenders are most commonly either unknown to the perpetrator or persons of authority, and that the crimes are often perpetrated without apparent provocation or reason, is important information for all professionals who come into contact with this group and should be taken into consideration in order to assess risk more accurately.
HyU: Hybrid Unmixing for longitudinal in vivo imaging of low signal to noise fluorescence
Authors: Chiang Hsiao , Koo Daniel , Kitano Masahiro , Unruh Jay , Trinh Le , Fraser Scott , Cutrale Francesco
Published: January 2022

The expanded application of fluorescence imaging in biomedical and biological research towards more complex systems and geometries requires tools that can analyze a multitude of components at widely varying time- and length-scales. The major challenge in such complex imaging experiments is to cleanly separate multiple fluorescent labels with overlapping spectra from one another and background autofluorescence, without perturbing the sample with high levels of light. Thus, there is a requirement for efficient and robust analysis tools capable of quantitatively separating these signals.
In response, we have combined multispectral fluorescence microscopy with hyperspectral phasors and linear unmixing to create Hybrid Unmixing (HyU). Here we demonstrate its capabilities in the dynamic imaging of multiple fluorescent labels in live, developing zebrafish embryos. HyU is more sensitive to low light levels of fluorescence compared to conventional linear unmixing approaches, permitting better multiplexed volumetric imaging over time, with less bleaching. HyU can also simultaneously image both bright exogenous and dim endogenous labels because of its high dynamic range. This allows studies of cellular behaviors, tagged components, and cell metabolism within the same specimen, offering a powerful window into the orchestrated complexity of biological systems.
Forces that control self-organization of chemically-propelled Janus tori
Authors: Aronson Igor , Wang Jiyuan , Huang Mu-Jie , Baker-Sediako Remmi , Kapral Raymond
Published: January 2022

Control of the individual and collective behavior of self-propelled synthetic micro-objects has immediate application for nanotechnology, robotics, and precision medicine. Despite significant progress in the synthesis and characterization of self-propelled Janus (two-faced) particles, predictive understanding of their behavior remains challenging, especially if the particles have anisotropic forms. Here, by using molecular simulation, we describe the interactions of chemically-propelled microtori near a wall. The results show that a torus hovers at a certain distance from the wall due to a combination of gravity and hydrodynamic flows generated by the chemical activity. Moreover, electrostatic dipolar interactions between the torus and the wall result in a spontaneous tilt and horizontal translation, in a qualitative agreement with the experiment. Simulations of the dynamics of two tori near a wall provide evidence for the formation of stable self-propelled bound states. Our results illustrate that self-organization at the microscale occurs due to a combination of multiple factors, including hydrodynamic, chemical, and electrostatic interactions.
Clinical Predictors of Survival for Patients with Atypical Teratoid/Rhabdoid Tumors
Authors: Bachu Vismaya S , Shah Pavan , Jimenez Adrian E , Khalafallah Adham M , Tailor Jignesh , Mukherjee Debraj , Cohen Alan R
Published: January 2022

Purpose: Atypical teratoid/rhabdoid tumors (AT/RT) are malignant central nervous system (CNS) neoplasms of the young. Our study analyzed a large AT/RT cohort from the National Cancer Database (NCDB) to elucidate predictors of short-term mortality and overall survival (OS). Methods: Information was collected on patients with histologically-confirmed AT/RT using the NCDB (2004-2016). Kaplan-Meier analysis indicated OS. Prognostic factors for 30-day mortality, 90-day mortality, and OS were determined via multivariate Cox proportional-hazards (CPH) and logistic regression models. Results: Our cohort of 189 patients had a median age of 1 year (IQR [1, 4]) and tumor size of 4.7±2.0 cm at diagnosis. Seventy-two percent were under 3 years old; 55.6% were male and 71.0% were Caucasian. Fifty (27.2%) patients received only surgery (S) (OS=5.91 months), 51 (27.7%) received surgery and chemotherapy (S+CT) (OS=11.2 months), and 9 (4.89%) received surgery and radiotherapy (S+RT) (OS=10.3 months). Forty-five (24.5%) received S+CT+RT combination therapy (OS=45.4 months), 13 (17.1%) received S+CT+BMT/SCT (bone marrow or stem cell transplant) (OS=55.5 months), and 16 (8.70%) received S+CT+RT+BMT/SCT (OS=68.4 months). Bivariate analysis of dichotomized age (HR=0.550, 95% CI[0.357, 0.847], p=0.0067) demonstrated significantly increased patient survival if diagnosed at or above 1 year old. On multivariate analysis, administration of S+CT+RT, S+CT+BMT/SCT, or S+CT+RT+BMT/SCT combination therapy predicted significantly (p<0.05) increased OS compared to surgery alone. Conclusion: AT/RTs are CNS tumors where those diagnosed under 1 year old have a significantly worse prognosis. Our study demonstrates that while traditional CT, RT, and BMT/SCT combination regimens prolong life, overall survival in this population is still low.