bluuebunny/crossref_metadata_2025 huggingface dataset:
TGF-β1, pSmad-2/3, Smad-7, and β-Catenin Are Augmented in the Pulmonary Arteries from Patients with Idiopathic Pulmonary Fibrosis (IPF): Role in Driving Endothelial-to-Mesenchymal Transition (EndMT)
Authors: Gaikwad Archana Vijay , Eapen Mathew Suji , Dey Surajit , Bhattarai Prem , Shahzad Affan Mahmood , Chia Collin , Jaffar Jade , Westall Glen , Sutherland Darren , Singhera Gurpreet Kaur , Hackett Tillie-Louise , Lu Wenying , Sohal Sukhwinder Singh
Published: February 2024

Background: We have previously reported that endothelial-to-mesenchymal transition (EndMT) is an active process in patients with idiopathic pulmonary fibrosis (IPF) contributing to arterial remodelling. Here, we aim to quantify drivers of EndMT in IPF patients compared to normal controls (NCs). Methods: Lung resections from thirteen IPF patients and eleven NCs were immunohistochemically stained for EndMT drivers, including TGF-β1, pSmad-2/3, Smad-7, and β-catenin. Intima, media, and adventitia were analysed for expression of each EndMT driver in pulmonary arteries. Computer- and microscope-assisted Image ProPlus7.0 image analysis software was used for quantifications. Results: Significant TGF-β1, pSmad-2/3, Smad-7, and β-catenin expression was apparent across all arterial sizes in IPF (p < 0.05). Intimal TGF-β1, pSmad-2/3, Smad-7, and β-catenin were augmented in the arterial range of 100–1000 μm (p < 0.001) compared to NC. Intimal TGF-β1 and β-catenin percentage expression showed a strong correlation with the percentage expression of intimal vimentin (r′ = 0.54, p = 0.05 and r′ = 0.61, p = 0.02, respectively) and intimal N-cadherin (r′ = 0.62, p = 0.03 and r′ = 0.70, p = 0.001, respectively). Intimal TGF-β1 and β-catenin expression were significantly correlated with increased intimal thickness as well (r′ = 0.52, p = 0.04; r′ = 0.052, p = 0.04, respectively). Moreover, intimal TGF-β1 expression was also significantly associated with increased intimal elastin deposition (r′ = 0.79, p = 0.002). Furthermore, total TGF-β1 expression significantly impacted the percentage of DLCO (r′ = −0.61, p = 0.03). Conclusions: This is the first study to illustrate the involvement of active TGF-β/Smad-2/3-dependent and β-catenin-dependent Wnt signalling pathways in driving EndMT and resultant pulmonary arterial remodelling in patients with IPF. EndMT is a potential therapeutic target for vascular remodelling and fibrosis in general in patients with IPF.
Influence of Cementation Mode and Ferrule Design on the Fatigue Resistance of Monolithic Zirconia Endocrowns
Authors: Stoilov Milan , Boehmer Tobias , Stoilov Lea , Stark Helmut , Marder Michael , Enkling Norbert , Kraus Dominik
Published: February 2024

Background: Classic endocrowns made of dental ceramics are considered a promising alternative to traditional post-endodontic restorations. The use of circular ferrules in endocrowns is a topic of controversial discussion. Therefore, the present study aims to evaluate the effect of ferrule design and cementation mode on the fatigue resistance of zirconia endocrowns. Methods: Eighty human molars were divided into four groups (n = 20): NFC (no-ferrule, conventional cementation), NFA (no-ferrule, adhesive luting), FC (ferrule, conventional cementation) and FA (ferrule, adhesive luting). Both the classic and the modified endocrown preparation with a two-millimeter ferrule design were carried out. Endocrowns were fabricated from zirconia using the CEREC system. After thermocycling, specimens were loaded according to the step-stress test up to 1500 N. Results: Failure rate was low; 88.8% of total specimens passed the step-stress test. Fractures were distributed between all groups; no significant differences in fatigue resistance were detected for preparation design and cementation mode. Conclusions: Endocrowns appear to be a promising concept for endodontically treated molars. Ferrule and also cementation mode have only a minor influence on fatigue resistance of zirconia endocrowns. However, at very high forces, the marginal area of the ferrule represents a weak point.
Current Challenges in the Management of Vitreoretinal Conditions
Authors: Panos Georgios D.
Published: February 2024

In the dynamic realm of ophthalmology, the management of vitreoretinal conditions stands as a testament to both significant progress and ongoing challenges [...]
Interactions between the Exocrine and the Endocrine Pancreas
Authors: Valente Roberto , Coppola Alessandro , Scandavini Chiara Maria , Halimi Asif , Magnusson Annelie , Lauro Augusto , Sotirova Ira , Arnelo Urban , Franklin Oskar
Published: February 2024

The pancreas has two main functions: to produce and secrete digestive enzymes (exocrine function) and to produce hormones that regulate blood glucose and splanchnic secretion (endocrine function). The endocrine and exocrine portions of the pancreas are central regulators in digestion and metabolism, with continuous crosstalk between their deeply interconnected components, which plays a role in disease. Pancreatic neoplasms, inflammation, trauma, and surgery can lead to the development of type 3c diabetes when an insult simultaneously damages both acini and islets, leading to exocrine and endocrine dysfunction. In diabetes mellitus patients, pancreatic exocrine insufficiency is highly prevalent, yet little is known about the associations between diabetes mellitus and pancreatic exocrine function. This review aims to provide an overview of the physiology of the pancreas, summarize the pathophysiology and diagnostic work-up of pancreatic exocrine insufficiency, and explore the relationships between exocrine pancreatic insufficiency and diabetes mellitus.
Management of Neuromuscular Blocking Agents in Critically Ill Patients with Lung Diseases
Authors: Iavarone Ida Giorgia , Al-Husinat Lou’i , Vélez-Páez Jorge Luis , Robba Chiara , Silva Pedro Leme , Rocco Patricia R. M. , Battaglini Denise
Published: February 2024

The use of neuromuscular blocking agents (NMBAs) is common in the intensive care unit (ICU). NMBAs have been used in critically ill patients with lung diseases to optimize mechanical ventilation, prevent spontaneous respiratory efforts, reduce the work of breathing and oxygen consumption, and avoid patient–ventilator asynchrony. In patients with acute respiratory distress syndrome (ARDS), NMBAs reduce the risk of barotrauma and improve oxygenation. Nevertheless, current guidelines and evidence are contrasting regarding the routine use of NMBAs. In status asthmaticus and acute exacerbation of chronic obstructive pulmonary disease, NMBAs are used in specific conditions to ameliorate patient–ventilator synchronism and oxygenation, although their routine use is controversial. Indeed, the use of NMBAs has decreased over the last decade due to potential adverse effects, such as immobilization, venous thrombosis, patient awareness during paralysis, development of critical illness myopathy, autonomic interactions, ICU-acquired weakness, and residual paralysis after cessation of NMBAs use. The aim of this review is to highlight current knowledge and synthesize the evidence for the effects of NMBAs for critically ill patients with lung diseases, focusing on patient–ventilator asynchrony, ARDS, status asthmaticus, and chronic obstructive pulmonary disease.
A Review of Animal Models Investigating the Reproductive Effects of Gender-Affirming Hormone Therapy
Authors: Raja Nicholas S. , Rubin Elizabeth S. , Moravek Molly B.
Published: February 2024

Gender-affirming hormone therapy (GAHT) is an important component in the process of transitioning for many transgender and gender-diverse (TGD) individuals. Multiple medical organizations recommend fertility preservation counseling prior to initiation of GAHT; however, there remains little high-quality data regarding the impact of GAHT on fertility and reproductive function. A PubMed literature review was performed using Boolean search operators linking keywords or phrases such as “mouse”, “rat”, “primate”, “animal model”, “transgender”, “gender”, “estrogen”, “testosterone”, “fertility”, and “fertility preservation”. Recent research has produced a number of animal models of GAHT that utilize similar hormonal regimens and produce similar phenotypic results to those used and observed in human patients. Specific to testosterone(T)-containing GAHT, animals demonstrate loss of menstrual cyclicity with therapy, resumption of menses on cessation of therapy, suppression of gonadotropin levels, and physical changes such as clitoromegaly. Models mimicking GAHT for transmasculine individuals in the peripubertal period demonstrate that pretreatment with GnRHa therapy does not modify the effects of subsequent T administration, which were similar to those described in adult models. Both models suggest promising potential for future fertility with cessation of T. With estradiol (E)-containing GAHT, animals exhibit decreased size of testicles, epididymis, and seminal vesicles, as well as ongoing production of spermatocytes, and seminiferous tubule vacuolization. Given the ethical challenges of conducting human studies in this area, high-fidelity animal models represent a promising opportunity for investigation and could eventually transform clinical counseling about the necessity of fertility preservation. Future studies should better delineate the interactions (if any exist) between treatment attributes such as dosing and duration with the extent of reversibility of reproductive perturbations. The development of models of peripubertal feminizing GAHT is an additional area for future work.
Coral Tissue Regeneration and Growth Is Associated with the Presence of Stem-like Cells
Authors: Levanoni Jonathan , Rosner Amalia , Lapidot Ziva , Paz Guy , Rinkevich Baruch
Published: February 2024

Members of the Cnidaria phylum were studied for centuries to depict the source of their unprecedented regeneration capacity. Although adult stem cells (ASCs) have been recognized in tissue growth/regeneration in many hydrozoans, there has not been any evidence of them in the ancestral Anthozoa class. This study sheds light on the development of epidermal epithelium expansion, akin to blastema, during tissue regeneration after small circular incisions (each 2.77 mm2) and during the natural expansion of tissue across a flat surface in the scleractinian coral Stylophora pistillata. Regeneration was completed within 9 days in 84.5% (n = 64) of the assays. About 35% of the samples regrew a single polyp, 60% showed no polyp regrowth, and approximately 6% exhibited multiple new polyps. We further used histological staining, pH3, Piwi immuno-histochemistry, and qPCR for eight stemness markers: Piwi-1, Nanos-1, Nanos-1-like, Tudor-5, Tudor-7, Boule, Sox-2, and Myc-1. The results revealed the formation of an “addendum”, an epidermal epithelium in the growing edges (in regenerating and normal-growing fronts) inhabited by a cluster of small cells featuring dense nuclei, resembling ASCs, many expressing pH3 as well as Piwi proteins. Most of the stemness genes tested were upregulated. These results indicate the participation of ASCs-like cells in tissue regeneration and growth in scleractinian corals.
Multi-Attention Pyramid Context Network for Infrared Small Ship Detection
Authors: Guo Feng , Ma Hongbing , Li Liangliang , Lv Ming , Jia Zhenhong
Published: February 2024

In the realm of maritime target detection, infrared imaging technology has become the predominant modality. Detecting infrared small ships on the sea surface is crucial for national defense and maritime security. However, the challenge of detecting infrared small targets persists, especially in the complex scenes of the sea surface. As a response to this challenge, we propose MAPC-Net, an enhanced algorithm based on an existing network. Unlike conventional approaches, our method focuses on addressing the intricacies of sea surface scenes and the sparse pixel occupancy of small ships. MAPC-Net incorporates a scale attention mechanism into the original network’s multi-scale feature pyramid, enabling the learning of more effective scale feature maps. Additionally, a channel attention mechanism is introduced during the upsampling process to capture relationships between different channels, resulting in superior feature representations. Notably, our proposed Maritime-SIRST dataset, meticulously annotated for infrared small ship detection, is introduced to stimulate advancements in this research domain. Experimental evaluations on the Maritime-SIRST dataset demonstrate the superiority of our algorithm over existing methods. Compared to the original network, our approach achieves a 6.14% increase in mIOU and a 4.41% increase in F1, while maintaining nearly unchanged runtime.
Research on Three-Closed-Loop ADRC Position Compensation Strategy Based on Winch-Type Heave Compensation System with a Secondary Component
Authors: Li Shizhen , Wu Qinfeng , Liu Yufeng , Qiao Longfei , Guo Zimeng , Yan Fei
Published: February 2024

To mitigate the interference of waves on an offshore operation ship, heave compensation systems find widespread application. The performance of heave compensation systems significantly influences the efficiency and safety of maritime operations. This study established a mathematical model for a winch-based active heave compensation system. It introduced a three-loop active disturbance rejection control (ADRC) strategy that encompasses piston position control, winch speed control, and load-displacement control to enable the real-time estimation and compensation of system disturbances, thereby enhancing the performance of the heave compensation system. To assess the effectiveness of this control strategy, this study employed Matlab/Simulink and AMESim to construct a co-simulation model and conducted a comparative analysis with traditional proportional integral derivative (PID) control systems. The research findings indicate that the three-loop ADRC position control strategy consistently delivered superior compensation performance across various operational scenarios.
A Novel, Finite-Time, Active Fault-Tolerant Control Framework for Autonomous Surface Vehicle with Guaranteed Performance
Authors: Wang Xuerao , Ouyang Yuncheng , Wang Xiao , Wang Qingling
Published: February 2024

In this paper, a finite-time, active fault-tolerant control (AFTC) scheme is proposed for a class of autonomous surface vehicles (ASVs) with component faults. The designed AFTC framework is based on an integrated design of fault detection (FD), fault estimation (FE), and controller reconfiguration. First, a nominal controller based on the Barrier Lyapunov function is presented, which guarantees that the tracking error converges to the predefined performance constraints within a settling time. Then, a performance-based monitoring function with low complexity is designed to supervise the tracking behaviors and detect the fault. Different from existing results where the fault is bounded by a known scalar, the FE in this study is implemented by a finite-time estimator without requiring any prioir information of fault. Furthermore, under the proposed finite-time AFTC scheme, both the transient and steady-state performance of the ASV can be guaranteed regardless of the occurrence of faults. Finally, a simulation example on CyberShip II is given to confirm the effectiveness of the proposed AFTC method.
Dynamic Positioning Control of Large Ships in Rough Sea Based on an Improved Closed-Loop Gain Shaping Algorithm
Authors: Song Chunyu , Guo Teer , Sui Jianghua , Zhang Xianku
Published: February 2024

In order to solve the problem of the dynamic positioning control of large ships in rough sea and to meet the need for fixed-point operations, this paper proposes a dynamic positioning controller that can effectively achieve large ships’ fixed-point control during Level 9 sea states (wind force Beaufort No. 10). To achieve a better control effect, a large ship’s forward motion is decoupled to establish a mathematical model of the headwind stationary state. Meanwhile, the closed-loop gain shaping algorithm is combined with the exact feedback linearization algorithm to design the speed controller and the course-keeping controller. This effectively solves the problem of strong external interferences impacting the control system in rough seas and guarantees the comprehensive index of robustness performance. In this paper, three large ships—the “Mariner”, “Taian kou”, and “Galaxy”—are selected as the research objects for simulation research and the final fixing error is less than 10 m. It is proven that the method is safe, feasible, practical, and effective, and provides technical support for the design and development of intelligent marine equipment for use in rough seas.
Review on Sensors for Sustainable and Safe Maritime Mobility
Authors: Briguglio Giovanni , Crupi Vincenzo
Published: February 2024

The increasingly stringent requirements—in terms of limiting pollutants and the constant need to make maritime transport safer—generated the necessity to foresee different solutions that are original. According to the European Maritime Safety Agency, the total number of reported marine casualties and incidents is 21.173 over the period 2014–2021, with a yearly average of 2.647 casualties and incidents. According to the same source, 495 cases of pollution were reported in the period from 2014 to 2021. Marine pollution by ships’ fuel and other pollutants is linked to 64.2% of all pollution. It is mandatory to offer a new kind of ship that can exploit new technologies to increase safety for people and onboard goods. It has been found that existing marine structures for maritime mobility do not have essential sensors for avoiding emergency situations such as flooding, oil spills, or health situations requiring efficient monitoring. In addition, there is a lack of legislation defining the insertion of unmanned vehicles into the actual marine infrastructure. This review highlighted the strengths and weaknesses of sensors in the maritime sector, intensifying areas of improvement for future challenges, such as sensor energy efficiency, data processing, sensor fusion methodologies, and accurate sea state description with environmental monitoring by means of unmanned vehicles.
The Mediterranean Zoanthid Parazoanthus axinellae as a Novel Source of Antimicrobial Compounds
Authors: Stabili Loredana , Piraino Stefano , Rizzo Lucia
Published: February 2024

Marine bioprospecting is a dynamic research field that explores the oceans and their biodiversity as noteworthy sources of new bioactive compounds. Anthozoans are marine animals belonging to the Cnidaria phylum characterized by highly specialized mechanosensory cells used both for defence against predators and prey capture. Here, high concentration of cnidocysts have been isolated from the Mediterranean zoanthid coral Parazoanthus axinellae (Schmidt, 1862) and their antimicrobial potential has been investigated. The cnidocyst extract exerted significant antibacterial activity against some human pathogens capable of developing resistance to conventional antibiotics such as Streptococcus agalactiae and Coccus sp., and against several Vibrio species, including some microbial strains for humans and farmed fish, such as Vibrio alginolyticus, Vibrio anguillarum, Vibrio fischeri, Vibrio harveyi, and Vibrio vulnificus. Results have been discussed in light of both the ecological aspects and biotechnological value of the cnidocyst extract in the nutritional, nutraceutical, and pharmaceutical fields.
Machine Learning-Based Approach to Identifying Fall Risk in Seafarers Using Wearable Sensors
Authors: Choi Jungyeon , Knarr Brian A. , Youn Jong-Hoon , Song Kwang Yoon
Published: February 2024

Falls on a ship cause severe injuries, and an accident falling off board, referred to as “man overboard” (MOB), can lead to death. Thus, it is crucial to accurately and timely detect the risk of falling. Wearable sensors, unlike camera and radar sensors, are affordable and easily accessible regardless of the weather conditions. This study aimed to identify the fall risk level (i.e., high and low risk) among individuals on board using wearable sensors. We collected walking data from accelerometers during the experiment by simulating the ship’s rolling motions using a computer-assisted rehabilitation environment (CAREN). With the best features selected by LASSO, eight machine learning (ML) models were implemented with a synthetic minority oversampling technique (SMOTE) and the best-tuned hyperparameters. In all ML models, the performance in classifying fall risk showed overall a good accuracy (0.7778 to 0.8519), sensitivity (0.7556 to 0.8667), specificity (0.7778 to 0.8889), and AUC (0.7673 to 0.9204). Logistic regression showed the best performance in terms of the AUC for both training (0.9483) and testing (0.9204). We anticipate that this study will effectively help identify the risk of falls on ships and aid in developing a monitoring system capable of averting falls and detecting MOB situations.
Identification of Chromoblastomycosis and Phaeohyphomycosis Agents through ITS-RFLP
Authors: Sousa Gabriel S. M. , De Oliveira Rodrigo S. , De Souza Alex B. , Monteiro Ruan C. , Santo Elaine P. T. E. , Franco Filho Luciano C. , Da Silva Silvia H. M.
Published: February 2024

Chromoblastomycosis (CBM) and phaeohyphomycosis (FEO) are infections caused by melanized filamentous fungal agents, primarily found in tropical and subtropical regions. Both infections pose significant challenges for the correct identification of the causative agent due to their morphological similarity, making conventional methods of morphological analysis highly subjective. Therefore, molecular techniques are necessary for the precise determination of these species. In this regard, this study aimed to contribute to a new methodology based on PCR-RFLP for the identification of agents causing CBM and FEO. Sequences from the Internal Transcribed Spacer (ITS) region were used to identify potential restriction enzyme sites in silico, followed by in vitro validation using the selected restriction enzymes. The obtained results were compared with species identification through morphological analyses and sequencing. The results demonstrated that the PCR-RFLP applied in this study accurately identified two major agents of chromoblastomycosis, Fonsecaea pedrosoi and Fonsecaea monophora, as well as Cladophialophora bantiana and Exophiala dermatitidis, both causative agents of phaeohyphomycosis. In this context, the proposed assay can complement current methods for identifying these species, aiding in diagnosis, and contributing to the proper management of these infections.
Assessing the Impact of Organ Failure and Metastases on Quality of Life in Breast Cancer Patients: A Prospective Study Based on Utilizing EORTC QLQ-C30 and EORTC QLQ-BR45 Questionnaires in Romania
Authors: Ionescu (Miron) Andreea-Iuliana , Anghel Alexandra-Valentina , Antone-Iordache Ionuț-Lucian , Atasiei Dimitrie-Ionuț , Anghel Cătălin-Alexandru , Barnonschi Andrei-Alexandru , Bobolocu Alexandra-Maria , Verga Catinca , Șandru Florica , Lișcu Horia-Dan
Published: February 2024

Breast cancer (BC) significantly impacts the quality of life (QoL) of affected individuals. This study, conducted at Colțea Clinical Hospital, Bucharest, aimed to assess the impact of organ failures and metastases on QoL in breast cancer patients using EORTC QLQ-C30 and EORTC QLQ-BR45 questionnaires and the survival rate to understand the clinical journey and the quality of life status in breast cancer patients. From January 2019 to October 2022, a prospective, observational study surveyed 874 patients, revealing 201 fatalities, 66 refusals, and 607 eligible participants. Results indicated statistically significant differences in various QoL aspects for patients experiencing heart failure, including physical functioning, pain, insomnia, global health status, and overall summary score. Kidney failure exhibited significance in physical functioning for QLQ-C30 and body image, sexual functioning, and endocrine sexual symptoms for QLQ-BR45. Respiratory failure demonstrated significant differences across multiple QoL domains. Patients with bone metastases reported lower physical functioning (p = 0.006) and increased pain (p = 0.002). This study has revealed an overall 5-year life expectancy of 68.8%, with survival rates of 93.8% for Stage I, 86.3% for Stage II, and 77.2% for Stage III breast cancer. Metastatic cancer patients have shown a 35.6% survival rate over 45 months, with a median survival duration of 36 months. A significant limitation of our study was the administration of the questionnaire only once, preventing us from quantifying the impact of specific treatment types on quality of life. This study emphasizes the necessity of using standardized QoL assessments in clinical practice from the initial presentation to ongoing follow-up.
Sensitivity of Multi-Criteria Analysis Methods in Rural Land Consolidation Project Ranking
Authors: Marinković Goran , Ilić Zoran , Nestorović Žarko , Božić Marko , Bulatović Vladimir
Published: February 2024

Decisions around distributing available funds among potential land consolidation projects require a thorough analysis in order to maximize the effects of land consolidation. In order to avoid choosing the wrong land consolidation projects, different methods can be used. Generally, there are two possible groups of methods: one based on a qualitative approach (DELPHI; SWOT) and one based on a quantitative approach (AHP, VIKOR, SAW, TOPSIS, etc.). In this research, the focus was on the sensitivity of the resulting rankings affected by varying the input data in multi-criteria analysis methods, with an emphasis on the variation in the weight and the choice of criteria. This research was motivated by the subjective character of the choice of criteria and their weighting before applying the multi-criteria analysis methods. Four methods were included (AHP, TOPSIS, VIKOR, and SAW) for the multi-criteria analysis, with three ways of defining weights (consistent, modified, or quasi-consistent and freely determined without taking consistency into account), in order to determine the influence of the different methods on the final ranking. The weights were defined only by an acceptable interval of values. The sensitivity of the methods was investigated using the differences in the obtained rankings between each method. A case study is provided on real data, and the results are discussed. The results showed a relatively small variance and possible equal rankings of projects by means of statistical analyses. This finding opens up the possibility of the valuation of projects instead of simple rankings.
Fixability–Flexibility Relations in Sustainable Territorial Spatial Planning in China: A Review from the Food–Energy–Water Nexus Perspective
Authors: Shan Liping , Zhang Chuyi , Zhou Tianxiao , Wu Yuzhe , Zhang Liang , Shan Jiaming
Published: February 2024

Territorial spatial planning involves fixability and flexibility in different driving factors related to control and development orientation, and they play an important role in regional sustainable development, especially in developing countries such as China. With rapid urbanisation and industrialisation, China has been impacted by conflicts between development and protection in territorial space. To integrate the contradictions among different territorial spatial planning measures, planners and scholars have started to focus on studies regarding fixability–flexibility relationships and integration. However, the relationship between and integration of fixability and flexibility in territorial spatial planning have yet to be clearly summarised. This paper explores an innovative research direction for the fixability–flexibility relations in territorial spatial planning from a new perspective, the Food–Energy–Water Nexus, which is a dynamic and comprehensive framework for Sustainable Development Goals (SDGs) studies. This paper covers the existing research on fixability and flexibility in territorial spatial planning. Moreover, after summarising the conflicts of fixability and flexibility, the dialectical relationship between and the integration of fixability and flexibility are researched.
The Impact of Dialect Diversity on Rent-Free Farmland Transfers: Evidence from Chinese Rural Household Surveys
Authors: Li Shangpu , Jiang Ye , Luo Biliang , Zheng Xiaodan
Published: February 2024

The rent-free farmland transfer that exists widely in China’s rural areas is a topic worthy of attention. Particularly, the regional heterogeneity of its occurrences implies regional cultural heterogeneities. Using local dialects to proxy regional cultural features, this study applies econometric methods to examine the impacts of dialect diversity on rent-free farmland transfers. It also considers possible mechanisms through a mediation analysis, based on a combined two-year rural household survey dataset from the Guangdong and Jiangxi Provinces in 2015 and 2016. Robust estimation results reveal that dialect diversity increases the probability of rent-free farmland transfers at the household and village levels. According to the mediation analysis, dialect diversity influences villages’ farmland abandonment, rural farmland market development, and the flexibility of farmland transfer contracts, which further affects rent-free farmland transfer. Rent-free farmland transfer depends on social trust and contracts’ self-fulfilling advantages. Therefore, cultural and traditional factors should be taken into consideration, which would form beneficial interactions between the selections of rural farmland institutional arrangement and land rights policy implementations.
Military Activity Impact on Vegetation in Pannonian Dry Sandy Grasslands
Authors: Bajnok Márta , Penksza Károly , Fűrész Attila , Penksza Péter , Csontos Péter , Szentes Szilárd , Stilling Ferenc , Saláta-Falusi Eszter , Fuchs Márta , Melenya Caleb , Házi Judit , Balogh Dániel , Wagenhoffer Zsombor
Published: February 2024

The conservation of dry sandy grasslands is a global issue because of the restoration and conservation of endangered ecosystems to provide a sufficient amount of forage under warming and drying climatic conditions. Our aim was to explore the impact of military activity on sandy grasslands in Hungary. The sample areas chosen were the Little Hungarian Plain (I. and II.) and the Great Hungarian Plain (III.), consisting abandoned, restored areas; still-active military exercise fields; and shooting ranges. In each sample area, six to ten coenological surveys were made. Based on our survey, the closed natural sandy grassland was documented only in the Little Hungarian Plain and were found rich in species. The open sandy grassland was described in all studied sites, Festuca vaginata appeared in all of them, while Festuca pseudovaginata was observed only in the Great Hungarian Plain. In the open sandy grassland, the natural vegetation had the highest cover value (78.8%), the sowed grassland area had the least cover value (53.3%), while the III. sample area was also poor in coverage (56.5%) but consisted of a natural species composition favorable for restoration. Our results confirmed the indirect role of military activity in the successful habitat conservation of Pannonian dry sandy grassland ecosystems.
Enhancing Urban Landscape Design: A GAN-Based Approach for Rapid Color Rendering of Park Sketches
Authors: Chen Ran , Zhao Jing , Yao Xueqi , He Yueheng , Li Yuting , Lian Zeke , Han Zhengqi , Yi Xingjian , Li Haoran
Published: February 2024

In urban ecological development, the effective planning and design of living spaces are crucial. Traditional color plan rendering methods, mainly using generative adversarial networks (GANs), rely heavily on edge extraction. This often leads to the loss of important details from hand-drawn drafts, significantly affecting the portrayal of the designer’s key concepts. This issue is especially critical in complex park planning. To address this, our study introduces a system based on conditional GANs. This system rapidly converts black-and-white park sketches into comprehensive color designs. We also employ a data augmentation strategy to enhance the quality of the output. The research reveals: (1) Our model efficiently produces designs suitable for industrial applications. (2) The GAN-based data augmentation improves the data volume, leading to enhanced rendering effects. (3) Our unique approach of direct rendering from sketches offers a novel method in urban planning and design. This study aims to enhance the rendering aspect of an intelligent workflow for landscape design. More efficient rendering techniques will reduce the iteration time of early design solutions and promote the iterative speed of designers’ thinking, thus improving the speed and efficiency of the whole design process.
The Impact of Internet Use on Land Productivity: Evidence from China Land Economy Survey
Authors: Deng Xiang , Peng Jie , Wan Chunlin
Published: February 2024

Enhancing land productivity is a crucial strategy for addressing key sustainable development issues, such as poverty reduction and ensuring food security. Farmers’ Internet use behavior offers the potential to improve land productivity. However, relatively little is known about the association between Internet use and land productivity. To fill this void, this study examines the impact of Internet use on land productivity and its mechanisms. The results indicate that farmers’ use of the Internet has a positive impact on improving agricultural land productivity. Internet use increases land productivity by 12.3%, and the conclusion still holds after a series of robustness tests and endogeneity tests. Heterogeneity analysis indicates that Internet use significantly enhances land productivity in the central and northern parts of Jiangsu Province, while it does not have the same effect in the province’s southern regions. Without the addition of county fixed effects, the central sample regression results show that the coefficient for Internet use is 0.165 and significant at the 10% confidence level. When county fixed effects are added, the coefficient decreases to 0.117 and is not significant. The coefficient on Internet use for the northern sample is 0.128 and is significant at the 5% confidence level. Mechanistic analyses demonstrate that Internet use also enhances land productivity primarily by expanding the cultivated land area, facilitating mechanized production, and strengthening farmers’ social networks. The results of the study indicate that the positive effects of Internet use in improving land productivity should be fully released by strengthening the communication infrastructure, further enhancing farmers’ Internet use capacity, improving the land transfer system, upgrading the socialized service level of agricultural machinery, and strengthening agricultural financial support.
Epidemiology and Risk Factors for Nosocomial Infections in Left Ventricular Assist Device Recipients
Authors: Mornese Pinna Simone , Corcione Silvia , Cavallone Elena , Shbaklo Nour , Vita Davide , De Benedetto Ilaria , Montrucchio Giorgia , Pasero Daniela , Trompeo Anna Chiara , Costamagna Andrea , Brazzi Luca , Rinaldi Mauro , Boffini Massimo , De Rosa Francesco Giuseppe
Published: February 2024

Left ventricular assist devices (LVADs) have been increasingly used as a valid option to improve the prognosis and reduce the symptoms of end-stage heart failure. However, long-term complications, mostly infections and coagulation disorders, are frequent. We described the epidemiology and risk factors for nosocomial infections (NIs) in a cohort of adult patients who underwent continuous-flow LVAD implant between January 2010 and December 2017 in Turin, Italy. Secondary outcomes were the prevalence of multidrug-resistant (MDR) bacteria and mortality. Results: Overall, 64 LVADs were implanted. A total of 32 (50%) patients experienced at least one episode of NI, with a total of 46 infectious events. VAD-related infections occurred in 22 patients (68.8%). Non VAD-related NIs occurred in 12 patients (37.5%), mainly low respiratory tract infections. Length of intensive care unit admission was a risk factor for NI (OR 1.224, 95%CI; 1.049, 1.429). Gram-negative bacilli were responsible for 58.8% of VAD-related infections and 79.5% of non-VAD related infections. In sixteen patients (50%), at least one episode of infection was related to an MDR strain. INTERMACS class and length of MV were independent risk factors for NIs by MDR strains (respectively, OR 2.12, 95%CI: 1.08, 6.80; p = 0.02 and OR 1.46, 95%CI: 1.07, 5.52, p = 0.047). In-hospital mortality was 6.3%. No differences in mortality were observed between infected and non-infected patients (p = 0.61) even when caused by MDR strains (p = 0.143). Conclusion: the rate of nosocomial infections in LVAD patients is associated with the length of ICU admission, and the etiology of nosocomial infection after LVAD implant is mainly due to GNB, including a high rate of MDR strains, especially KPC-KP and MDR PA.
Design and Control of a Climbing Robot for Autonomous Vertical Gardening
Authors: Jamšek Marko , Sajko Gal , Krpan Jurij , Babič Jan
Published: February 2024

This paper focuses on the development of a novel climbing robot that is designed for autonomous maintenance of vertical gardens in urban environments. The robot, designed with a unique five-legged structure, is equipped with a range of electrical and mechanical components, enabling it to autonomously navigate and maintain a specially designed vertical garden wall facilitating interactive maintenance and growth monitoring. The motion planning and control of the robot were developed to ensure precise and adaptive movement across the vertical garden wall. Advanced algorithms were employed to manage the complex dynamics of the robot’s movements, optimizing its efficiency and effectiveness in navigating and maintaining the garden structure. The operation of the robot in maintaining the vertical garden was evaluated during a two-week trial where the robot successfully performed nearly 8000 leg movements, with only 0.6% requiring human intervention. This demonstrates a high level of autonomy and reliability. This study concludes that the pentapod robot demonstrates significant potential for automating the maintenance of vertical gardens, offering a promising tool for enhancing urban green spaces.
Challenges and Opportunities in Electric Vehicle Charging: Harnessing Solar Photovoltaic Surpluses for Demand-Side Management
Authors: Bastida-Molina Paula , Rivera Yago , Berna-Escriche César , Blanco David , Álvarez-Piñeiro Lucas
Published: February 2024

The recharging of electric vehicles will undoubtedly entail an increase in demand. Traditionally, efforts have been made to shift their recharging to off-peak hours of the consumption curve, where energy demand is lower, typically during nighttime hours. However, the introduction of photovoltaic solar energy presents a new scenario to consider when synchronizing generation and demand curves. High-generation surpluses are expected during the central day hours, due to the significant contribution of this generation; these surpluses could be utilized for electric vehicle recharging. Hence, these demand-side management analyses present important challenges for electricity systems and markets. This research explores this overdemand avenue and presents a method for determining the ideal recharge curve of the electric vehicle. Consequently, with this objective of maximizing photovoltaic generation to cover as much of the foreseeable demand for electric vehicles as possible in future scenarios of the electrification of the economy, the six fundamental electric vehicle charging profiles have been analyzed. A practical scenario for 2040 is projected for the Canary Islands, estimating the potential levels of demand-side management and associated coverage. The coverage ranges from less than 20% to over 40%, considering the absence of demand-side management measures and the maximum displacement achievable through such measures.
Design and Construction of a Prototype of an Assisting Device for Arm Exercise
Authors: Ceccarelli Marco , Sanz Susana , Díaz Vicente , Russo Matteo
Published: February 2024

A new portable arm exercise device is presented as a laboratory prototype to assist arm movements in rehabilitation therapies and movement exercises. Unlike the devices currently used, a portable design is proposed, with easy assembly and operational characteristics that enable it to be used by users in the home and in a familiar environment. Sensors are also provided on the rotating crank to validate and monitor the efficiency of the arm exercise. A low-cost prototype is assembled using off-the-shelf components and 3D-printed parts. Design issues are discussed and elaborated on to build a prototype for future laboratory testing using fairly simple experimental methodology. Preliminary testing by one author shows good feasibility of the device. The findings from the experimental results can be summarized as effective smooth-monitored cyclic motion in the crank rotation with limited values for acceleration less than 1 g and for acting user forces less than 22 N. The values detected are significantly lower in the left hand, with the testing subject being right-handed and healthy, without injury to her upper limbs.
Multilevel Venous Obstruction in Patients with Cardiac Implantable Electronic Devices
Authors: Czajkowski Marek , Polewczyk Anna , Jacheć Wojciech , Kosior Jarosław , Nowosielecka Dorota , Tułecki Łukasz , Stefańczyk Paweł , Kutarski Andrzej
Published: February 2024

Background and Objectives: The nature of multilevel lead-related venous stenosis/occlusion (MLVSO) and its influence on transvenous lead extraction (TLE) as well as long-term survival remains poorly understood. Materials and Methods: A total of 3002 venograms obtained before a TLE were analyzed to identify the risk factors for MLVSO, as well as the procedure effectiveness and long-term survival. Results: An older patient age at the first system implantation (OR = 1.015; p < 0.001), the number of leads in the heart (OR = 1.556; p < 0.001), the placement of the coronary sinus (CS) lead (OR = 1.270; p = 0.027), leads on both sides of the chest (OR = 7.203; p < 0.001), and a previous device upgrade or downgrade with lead abandonment (OR = 2.298; p < 0.001) were the strongest predictors of MLVSO. Conclusions: The presence of MLVSO predisposes patients with cardiac implantable electronic devices (CIED) to the development of infectious complications. Patients with multiple narrowed veins are likely to undergo longer and more complex procedures with complications, and the rates of clinical and procedural success are lower in this group. Long-term survival after a TLE is similar in patients with MLVSO and those without venous obstruction. MLVSO probably better depicts the severity of global venous obstruction than the degree of vein narrowing at only one point.
How I Follow Hodgkin Lymphoma in First Complete (Metabolic) Remission?
Authors: Milunović Vibor
Published: February 2024

Hodgkin lymphoma is characterized by a high cure rate in the modern era of medicine regardless of stage, but patients suffer from a high risk of comorbidity associated with the administered therapy. The main aim of this review article is to assess and analyze the various comorbidities associated with Hodgkin lymphoma and address the survivorship of patients, including fertility, secondary cancers due to cardiovascular toxicity, and quality of life. Furthermore, this review explores the optimal strategy for detecting relapse. The treatment paradigm of Hodgkin lymphoma has shifted, with a paradigm shift toward achieving a high cure rate and low toxicity as a standard of care in this patient population. Checkpoint inhibitors, especially nivolumab, in combination with chemotherapy are increasingly being studied in the first line of therapy. However, their long-term toxicity remains to be assessed in longer follow-up. In conclusion, Hodgkin lymphoma survivors, regardless of their treatment, should be followed up individually by a multidisciplinary survivorship team in order to detect and properly treat the long-term side effects of therapy.
Hereditary Renal Cancer Syndromes
Authors: Yanus Grigory A. , Kuligina Ekaterina Sh. , Imyanitov Evgeny N.
Published: February 2024

Familial kidney tumors represent a rare variety of hereditary cancer syndromes, although systematic gene sequencing studies revealed that as many as 5% of renal cell carcinomas (RCCs) are associated with germline pathogenic variants (PVs). Most instances of RCC predisposition are attributed to the loss-of-function mutations in tumor suppressor genes, which drive the malignant progression via somatic inactivation of the remaining allele. These syndromes almost always have extrarenal manifestations, for example, von Hippel–Lindau (VHL) disease, fumarate hydratase tumor predisposition syndrome (FHTPS), Birt–Hogg–Dubé (BHD) syndrome, tuberous sclerosis (TS), etc. In contrast to the above conditions, hereditary papillary renal cell carcinoma syndrome (HPRCC) is caused by activating mutations in the MET oncogene and affects only the kidneys. Recent years have been characterized by remarkable progress in the development of targeted therapies for hereditary RCCs. The HIF2aplha inhibitor belzutifan demonstrated high clinical efficacy towards VHL-associated RCCs. mTOR downregulation provides significant benefits to patients with tuberous sclerosis. MET inhibitors hold promise for the treatment of HPRCC. Systematic gene sequencing studies have the potential to identify novel RCC-predisposing genes, especially when applied to yet unstudied populations.
Dissolution of CaO in SiO2-CaO-Al2O3 Slag in Si Production
Authors: Folstad Marit Buhaug , Einarsrud Kristian Etienne , Tangstad Merete
Published: February 2024

This work investigates the dissolution of CaO into three different compositions of SiO2-CaO-Al2O3 slag similar to those found in industrial Si furnaces. It was found that CaO dissolution into the slag is fast. During the dissolution process, a layer containing 35–42% CaO was formed between the CaO particle and the slag, which corresponded to the phases CaO·Al2O3·2SiO2 or 2CaO·Al2O3·SiO2 in this study. Two models were investigated to determine the dissolution rate of the three slags. In the first model, the CaO particle is assumed to be a smooth shrinking sphere, and the rate controlled by the chemical reaction rate. The second model assumes that the rate is controlled by mass transport and depends on the diffusion rate of CaO through a boundary layer on the surface of the CaO. Both models gave similar accuracy to the experimental values, and a proportional relationship between the rate constants and the viscosities was obtained. At 1500 °C, the diffusion coefficients were found to be in the order of 10−6 cm2/s.