bluuebunny/crossref_metadata_2025 huggingface dataset:
Stability and computational analyses of selected pesticides in use in the Republic of Serbia
Authors: Arsic Biljana , Petrovic Stefan , Mrmosanin Jelena , Dimitrijevic Ivana , Tosic Snezana , Stojanovic Gordana , Glisic Sanja , Milicevic Jelena
Published: December 2023

Pesticides commonly used in the Republic of Serbia (tebuconazole, pendimethalin, pyraclostrobin, propiconazole and famoxadone) have high stability, so their potential toxicity to humans needs to be investigated. These pesticides are in use in the Republic of Serbia in various formulations. Their toxicity and interactions with acetylcholinesterase were thoroughly investigated in this study using computational tools. The ADMET (adsorption, distribution, metabolism, excretion, toxicity) study showed that all of them are efficient oral compounds, and that pendimethalin was a mutagenic compound. Glide scores ranged from ?18.41 (pendimethalin) to ?27.61 kJ mol-1 (famoxadone) in Mus musculus, and from ?19.58 (pendimethalin) to ?24.31 kJ mol-1 (propiconazole) in Homo sapiens. In addition, the experimental stability of the pesticides solutions in methanol was studied using the fast gas chromatography?mass spectrometry (GC?MS, retention times of the studied pesticides ranged from 14.47 (pendimethalin) to 22 min (famoxadone)). They showed good stability over time, apart from pyraclostrobin which decomposed mainly into its desmethoxy derivative after 20 months. Based on the promising modelling results, pyraclostrobin and famoxadone emerge as potential candidates for further investigation in the treatment of Alzheimer?s disease, taking care to increase their stability.
Oxone® induced textile dyes degradation using cobalt-doped alumina catalyst
Authors: Marinovic Sanja , Mudrinic Tihana , Ajdukovic Marija , Jovic-Jovicic Natasa , Nikolova Dimitrinka , Bankovic Predrag , Novakovic Tatjana
Published: December 2023

Cobalt-doped alumina catalyst calcined at 500 ?C (CoA-500) was investigated
in the degradation of anionic textile dye Orange G in the presence of
Oxone?. Different reaction parameters were altered in order to study their
influence on Orange G degradation. The increase of the Oxone? dosage, mass
of the catalyst and temperature was beneficial for the dye degradation rate.
The best catalytic performance was obtained in the range of the initial
solution pH = 6-8. Simultaneous degradation of both Orange G and cationic
textile dye Basic blue 41, was also tested. The degradation of the Basic
blue 41 did not occur while Orange G was present in the system. CoA-500 was
found to be efficient catalyst in the Oxone? induced catalytic degradation
of textile dyes.
The influence of different radiopacifying agents on hermetical sealing ability of calcium silicate and calcium aluminate dental cements
Authors: Cetkovic Dejan , Zhiyu Cai , Vukovic Nemanja , Vukovic Zorica , Lei Huaxiang , Biocanin Vladimir , Huang Xiaojing , Jokanovic Vukoman , Antonijevic Djordje , Dozic Aleksandra
Published: December 2023

This study presents technological process for obtaining strontium enriched calcium silicate based dental ceramics and testing their microstructural and chemical properties. In brief, the influence of different radiopacifiers on microstructural properties of calciumsilicate (CaSi) and calcium-aluminate (CaAl) dental ceramics was evaluated. For synthesis of CaSi-based ceramics, calcium chloride pentahydrate (CaCl2?5H2O) and silica sol obtained by hydrothermal treatment were used. CaSi+barium-sulphate (BaSO4), CaSi + bismuth-oxide (Bi2O3), CaAl + zirconium-dioxide (ZrO2), CaAl + strontium-carbonate (SrCO3), CaAl+strontium-fluoride (SrF2), pure CaSi, pure CaAl and mineral trioxide aggregate (MTA) (control material) were used. The wettability, surface free energy (SFE), microporosity, nanoporosity and micro-gap size between the material and tooth root canal were evaluated. There was no difference in total SFE among tested cements (p<0.05), while CaSi+BaSO4, CaAl + SrCO3 and CaAl + SrF2 experienced superior wetting than other cements (p<0.05). The highest microporosity was observed in CaAl, whilst adding radiopacifiers into it decrease cements microporosity (p<0.05). The lowest nanoporosity was found for CaAl + ZrO2. The gap size was not statistically different among tested ceramics (p>0.05). Altogether, strontium containing radiopacyfiers result in improved microstructural characteristics of dental ceramics.
Outcomes With Finerenone in Patients With Chronic Kidney Disease and Type 2 Diabetes by Baseline Insulin Resistance
Authors: Ebert Thomas , D. Anker Stefan , M. Ruilope Luis , Fioretto Paola , Fonseca Vivian , E. Umpierrez Guillermo , L. Birkenfeld Andreas , Lawatscheck Robert , Scott Charlie , Rohwedder Katja , Rossing Peter
Published: December 2023

Objective To explore whether insulin resistance, assessed by estimated glucose disposal rate (eGDR), is associated with cardiorenal risk and whether it modifies finerenone efficacy. Research design and methods In FIDELITY (N=13,026), patients with type 2 diabetes, either I) urine albumin-to-creatinine ratio (UACR) ≥30–<300 mg/g and estimated glomerular filtration rate (eGFR) ≥25–≤90 mL/min/1.73 m2, or II) UACR ≥300–≤5000 mg/g and eGFR ≥25 mL/min/1.73 m2, and received optimized renin–angiotensin system blockade, were randomized to finerenone or placebo. Outcomes included cardiovascular (cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure) and kidney (kidney failure, sustained decrease ≥57% in eGFR from baseline, or renal death) composites. eGDR was calculated using waist circumference, hypertension status, and glycated hemoglobin for 12,964 patients. Results Median eGDR was 4.1 mg/kg/min. eGDR
The Molecular Architects of Life: Unraveling the Marvels of DNA Polymerases
Authors: Kankanamge Lakindu S. Pathira
Published: December 2023

In the intricate dance of cellular processes that underlie life, DNA polymerases emerge as the unsung heroes, tirelessly replicating the blueprint of existence with astonishing precision. These remarkable enzymes play a pivotal role in ensuring the faithful transmission of genetic information from one generation to the next. As we delve into the world of DNA polymerases, it becomes apparent that their diverse functions, structural intricacies, and evolutionary significance make them indispensable players in the symphony of life.
Investigation of the Cytotoxic Effect of Thorium on MRC-5 Cells
Authors: UM Yucel
Published: December 2023

Thorium is a naturally occurring radioactive metal belonging to the actinide group. It is found at low levels in water, soil, rocks, plants and animals. Thorium is used as a nuclear fuel in nuclear technology, and its compounds are used in industry, chemistry, mining, ceramic production and high-quality lens production. It also occurs naturally in different sources, including phosphate fertilizers used in agriculture. Its increasing role in the nuclear and defense industries poses a risk to human health as a result of occupational and accidental exposure. Thorium enters the body mainly through inhalation of contaminated dust. Studies conducted on workers have found that inhaling thorium dust will cause an increased the risk of developing lung diseases such as lung cancer. This study aimed to determine the cytotoxic effect of thorium on normal human lung fibroblast cells (MRC-5) exposed to thorium in vitro. For this purpose, MRC-5 cells were cultured in a 96-well plate (1x105 cells/well; 200 µl) containing 150 µM thorium (the stock solution was 1000 µg/ml in 5% HNO3). Cell viability (cytotoxicity status) was evaluated by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, yellow tetrazole (MTT) analysis method after 48 h of incubation. As a result of the MTT test, cell viability was determined as %99.52 in cells treated with 150 μM thorium. Accordingly, it was concluded that 150 μM thorium is not cytotoxic on MRC-5 cells. However, in later studies, it was decided to examine the cytotoxic effect of thorium at higher doses
Chemical Profile of Polyphenolic Compounds Present in the Red and White Varieties of Tunillo (Stenocereus stellatus) Fruit
Authors: JA Mendoza-Espinoza
Published: December 2023

Tunillo is a pre-Hispanic fruit native to the Mixtec region of Mexico. This fruit has been shown to have an antihyperglycemic effect, an effect associated with the content of total polyphenols; however, the chemical profile of this type of compounds present in the juice is not known, For this reason, the objective of this work was to determine the polyphenols present in the juice of tunillo (Stenocereus stellatus) of the red and white varieties by means of high performance liquid chromatography techniques and the presence of the main functional groups by infrared spectroscopy. It was found that gallic acid is the most abundant simple polyphenol in the white tunillo juice while chlorogenic acid is the most abundant in the red tunillo juice, being the white tunillo juice the one containing the highest amount of rutin and catechin. In conclusion, the chemical profile of the tunillo fruits shows differences in the content of polyphenols and flavonoids, so the routes of secondary metabolism and functional activity must be different.
STRATEGI INOVATIF KEPALA SEKOLAH DALAM PEMENUHAN HONORARIUM GURU TERDAFTAR DAPODIK DI SEKOLAH SWASTA
Authors: Hasan Fadli , Hidayati Dian
Published: December 2023

Honorarium for Quality Improvement (HPM) of Educators and Non-State Civil Apparatus (ASN) Education Personnel to improve welfare, quality of performance, and competency development to achieve the goal of education in Bandung. However, HPM for non-ASN honorary teachers has not been fully accommodated for honorary teachers in Bandung. This study aims to describe the system in making honorary teacher honorarium policies in private schools. The approach taken is qualitative, the data comes from observation, interviews, and documents. The research subjects were three private school principals in Bandung, and three school operators there. The first one represents a financially stable school and can make policies without fully involving the foundation. The second, represents a school that is financially secure and the foundation is fully involved in determining school policy. The last, represents a school that is not yet financially secure. The research finding is an alternative policy for the school principal in adapting mayor's regulation which has not yet accommodated honorary teachers for quality improvement honors whose data is based on the system. The steps were taken by private school principals to accommodate honorary teachers by adapting the mayor's regulations which were revealed to be the criteria for awarding honorariums for quality improvement.
Adjusting the Performance Properties of Products Obtained by Injection Molding from Polyamide
Authors:   KOSTAL Ukraine TOV, 2 Chervonoarmiytsiv avenue, Pereiaslav 08400, Ukraine, Prystynskyi Serhii
Published: December 2023

The influence of technological process parameters on the resistance to an aggressive environment (ethyl alcohol С2Н5ОН) of plastic parts obtained by injection molding from the polymer composite material polyamide 12 (РА12) was studied and shown.
CONTROL DIFUSO PARA PINZA ROBÓTICA BLANDA ORIENTADA A OBJETOS NO RÍGIDOS
Authors: Jiménez Moreno Robinson , Martínez Baquero Javier Eduardo , Agudelo Varela Oscar
Published: December 2023

El presente artículo expone el diseño de un efector robótico construido con sensórica interna en material flexible. Basados en el agarre bioinspirado de objetos delgados típicamente no rígidos realizados con dos dedos por os humanos, se establecen las características del modelo 3 que sirve de base para la impresión de este, incluyendo espacio interno para una flexoresistencia que permita identificar el porcentaje de flexión para agarre, mediante el efector.  Se diseña un controlador difuso para control del efector y dada la tolerancia del sensor se emplea un sistema de inferencia difusa Mamdani tipo-2. Los resultados muestran un agarre adecuado que permite obtener un error de estado estacionario cercano a cero, permitiendo agarrar objetos delgados como un pañuelo o una pieza de papel higiénico.
RETO DE LA INDUSTRIA 4.0 EN ENTORNOS EDUCATIVOS
Authors: Herrera Cáceres Matías , Vera Contreras Milton Jesús , Díaz Leal Nelly Rosana
Published: December 2023

El artículo presenta un proyecto exitoso de Innovación Curricular basado en la Metodología General Ajustada (MGA) y aprobado por la OCAD del Sistema Nacional de Regalías del Gobierno de Colombia. La propuesta central es un Laboratorio de Fabricación Digital (FabLab) que busca fomentar el autoaprendizaje, el aprendizaje colaborativo y por descubrimiento, impulsando así la innovación y el emprendimiento a través de la cooperación entre la Universidad, el sector productivo y los emprendedores. Esto crea un flujo positivo de ciencia, ingeniería y transformación digital de la sociedad. Las principales lecciones aprendidas incluyen la importancia del liderazgo, el trabajo en equipo, la confianza institucional, el trabajo virtual, la promoción del acceso abierto al conocimiento y la colaboración entre entidades educativas y gubernamentales.
SISTEMA DE IDENTIFICACIÓN Y CALIFICACIÓN DE ESTUDIANTES BASADOS EN TECNOLOGÍA NFC Y BLOCKCHAIN
Authors: Sánchez-Ruiz Fabián A. , Ricardo-Cárdenas Sebastián , Gómez-Gómez Jorge E.
Published: December 2023

La problemática que se trabaja en el documento aborda la precariedad de los sistemas tradicionales de llamado a lista que tienen algunas universidades. Se investigo sobre las características de los NFC y como se pueden utilizar para un sistema de identificación de personal académico para las universidades. Se tuvo en mente utilizar la blockchain para aprovechar la naturaleza descentralizada de esa red para asegurar la confidencialidad de los usuarios del sistema de identificación. Se desarrollo una arquitectura para aplicar estas dos tecnologías en un solo sistema que aproveche lo mejor de los sistemas centralizados y las redes descentralizadas. Esto permitió desarrollar una Dapp que permite la lectura de NFC's, las cuales serán los carnets de los asistentes de la universidad, para acceder a su información, rol e identificación en la universidad.
ANALISIS KEHILANGAN AIR IRIGASI DI SALURAN KR 2A KIRI DESA PURWODADI KECAMATAN TRIMURJO KABUPATEN LAMPUNG TENGAH
Authors: Riswan Riedo , Prawati Eri , Rolia Eva
Published: December 2023

Air irigasi merupakan sumberdaya pertanian yang sangat strategis. Agar jaringan irigasi tersebut dapat digunakan sesuai dengan fungsinya, maka diperlukan adanya pengelolaan jaringan irigasi yang efektif dan efesien. Pengelolaan jaringan irigasi akan mempengaruhi sistem pemberian air pada petak-petak sawah dan tingkat pelayanan irigasi yang diterima oleh petani. Pada musim kemarau kebutuhan air di areal pertanian Desa Purwodadi belum dapat terpenuhi, sehingga sangat berpengaruh pada hasil produksi petani. Hal tersebut terjadi kemungkinan dikarenakan pengelolaan air irigasi dan pendistribusiannya masih kurang merata.

Berdasarkan pada pernyataan di atas, maka peelitian ini dilakukan dengan maksud untuk mengkaji pemanfaatan dan penyaluran air irigasi pada areal persawahan tersebut. Areal persawahan yang dimaksud dialiri oleh saluran irigasi Kr 2A Kiri di Desa Purwodadi, Kecamatan Trimurjo Kabupaten Lampung Tengah. Penelitian ini dilakukan secara bertahap, langkah-langkah dalam pengumpulan data yaitu melakukan survei lokasi dengan mengukur dimensi saluran dan dimensi pintu air, melakukan penelitian dan perhitungan jumlah debit air yang masuk pada pukul 08.00 WIB, yang dilakukan adalah melihat tinggi air lalu diukur ketinggiannya, menghitung jumlah kebutuhan air di sawah dengan memperhitungkan faktor kehilangan air akibat faktor jarak, menghitung toal jumlah kehilangan air pada saluran yang diakibatkan oleh faktor rembesan, kesalahan operasional pintu air dan faktor jarak saluran ke petak sawah, lalu yang terakhir adalah menghitung tingkat efisiensi penyaluran air irigasi.

Dapat disimpulkan bahwa nilai kehilangan air pada saluran A adalah sebesar 0,10 m3/d dengan nilai efisiensi 84,76%, saluran A merupakan saluran yang memiliki persentase efisiensi terendah daripada saluran B dan C. Dimana saluran B memiliki nilai kehilangan air sebesar 0,05 m3/d dan nilai persentase efisiensi sebesar 91,84% sedangkan saluran C memiliki nilai kehilangan air sebesar 0,01 m3/d dengan nilai persentase efisiensi sebesar 98,98%.Faktor yang menyebabkan kehilangan air pada saluran SA, saluran SB, dan saluran SC adalah karena sebagian saluran masih belum ditalut dan masih banyaknya tanaman-tanaman liar yang tumbuh di sepanjang saluran irigasi.
ANALISIS HAMBATAN SAMPING TERHADAP AKTIVITAS PASAR TRADISONAL PADA RUAS JALAN PANGERAN SENOPATI KABUPATEN LAMPUNG SELATAN
Authors: Khamadani Iqbal , Putri Feby Aristia
Published: December 2023

Salah satu penyebab kemacetan adalah adanya hambatan samping. Tingginya aktivitas samping jalan berpengaruh besar terhadap kapasitas dan kinerja jalan pada suatu wilayah perkotaan, di antaranya seperti kendaraan berhenti dan parkir di badan jalan, pedestrian, kendaraan keluar masuk dari tata guna lahan tertentu ke badan jalan, dan kendaraan lambat. Daerah komersial dan aktivitas pasar sisi jalan merupakan kawasan yang memiliki tingkat hambatan samping yang paling tinggi. Pasar Tradisional Jatimuyo merupakan salah satu daerah komersil di Kabupaten Lampung Selatan serta merupakan salah satu pasar yang berada di sisi jalan menjadikannya memiliki tingkat hambatan samping yang cukup tinggi yang berpotensi menimbulkan penurunan kinerja jalan yang berada di dekatnya. Berdasarkan pengertian diatas, pada lokasi penelitian terdapat kegiatan kendaraan berhenti di badan jalan, parkir on-street, aktivitas-aktivitas pedestrian yang menggunakan badan jalan, kendaraan keluar masuk pasar, dan kendaraan lambat yang berpotensi menghasilkan hambatan samping dan mengganggu kinerja Jalan yang berada di sekitar Pasar Tradisional Jatimulyo. Melihat potensi kemacetan dan kecelakaan lalulintas yang dapat ditimbulkan dari hambatan samping aktivitas Pasar Tradisional Jatimulyo di Jalan Pangeran Senopati, peneliti kemudian mencoba menganalisis penelitian tentang pengaruh hambatan samping terhadap aktivitas Pasar Tradisional Jatimulyo pada ruas Jalan Pangeran Senopati Kabupaten Lampung Selatan.Data primer yang didapat dari hasil survei lapangan pada Ruas Jalan Pangeran Senopati diperoleh data masukan yang berupa data kondisi geometrik, data arus lalu lintas, data kondisi hambatan samping dan kapasitas jalan. Data sekunder yang digunakan berupa data jumlah penduduk Kabupaten Lampung Selatan, Survei dilakukan selama 7 hari, pada tiga jam puncak yaitu pagi, siang dan sore hari.Berdasarkan hasil penelitian yang dilakukan, Jalan Pangeran Senopati memiliki volume arus lalu lintas tertinggi terjadi di hari Senin 29 Mei 2023 dengan volume jumlah kendaraan 6919,25 Skr/Jam. Dari hasil peritungan hambatan samping, bobot kegiatan terbesar adalah hari senin jam 7.00 : 8.00 dengan jumlah total kegiatan 1928.40.
Formation of Foreign Language Communicative Competence of Schoolchildren Using Blended Learning Technology
Authors:   Southern Federal University, Krasnoshchekova Galina A. , Lagunova Olga A. ,   Southern Federal University
Published: December 2023

The article presents a methodology for developing foreign language communicative competence of school-children in senior grades of secondary schools based on blended learning technology. The relevance of the study is determined by the special role of digital and media resources in improving the quality of teaching for-eign languages. The methodology is implemented on the basis of competence-based, communicative-cognitive and integrative approaches to teaching foreign languages to high school students. The article de-scribes the methodical system of interrelated teaching of all types of speech activity on the basis of the author's textbook using authentic materials and modern information technologies at foreign language lessons, which contribute to the increase of motivation, efficiency and individualization of the educational process of forming foreign language communicative competence of schoolchildren. The methodology is aimed at developing self-discipline, perseverance and motivation in students in order to achieve good results in the studied language.
Scientific Conference as a Way of Forming the Experience of Research Activity among Students of Pedagogical University
Authors:   Omsk State Pedagogical University, Prishchenko Svetlana V. , Tsyganova Irina V. ,   Omsk State Pedagogical University
Published: December 2023

This article presents an analysis of the experience of the Department of General History, Sociology and Political Science of Omsk State Pedagogical University in holding a regional scientific conference “Problems of modern human knowledge”. The aim of the study is to identify the possibilities of this type of work in the context of the formation of future teachers’ competencies for the organization of research work in educational practice. The experience of the department in the preparation and holding of conferences in the period from 2016 to 2023 was studied. The authors conclude that the scientific conference is one of the most effective forms of pedagogical interaction between teachers and students, as well as one of the most effective ways for students of a pedagogical university to acquire research experience, which will be in demand by them when organizing educational and research work with schoolchildren.
Methodological Support for Rural Teachers through Individual Educational Routes
Authors:   Center for Continuous Professional Development, Ushnitskaya Sardaana E. , Alekseeva Efrosinya A. ,   S.N. Donskoy-II Education Development and Advanced Teacher Training Institute
Published: December 2023

The article is devoted to the problem of developing functional literacy of schoolchildren by teachers of rural schools in the Republic of Sakha (Yakutia). This topic is particularly relevant, since the predominant number of educational organizations in the region are located in rural areas. Methodological support for rural school teachers contributes to their professional development, which undoubtedly affects the quality of general educa-tion in the region. The article describes a study conducted by the authors aimed at identifying the readiness of rural teachers to form and develop functional literacy of schoolchildren. The results of the study revealed a con-tradiction between the high level of teachers’ understanding of the relevance of the task facing them and the insufficient level of formation of methodological competence in this area. The authors describe the experience of organizing methodological support for rural teachers in the development of functional literacy of schoolchil-dren based on the educational program “Development of functional literacy of schoolchildren” with the imple-mentation of an individual educational route developed by the regional Center for continuous professional de-velopment of teaching staff.
Place and Role of Miscegenation in the Process of the Regional Ethno-Demographic Development (Republic of Khakassia Case): To Problem Statement
Authors:   Far Eastern Federal University, Vinokurova Anna V. ,   Khakass Research Institute of Language, Literature and History
Published: December 2023

The article discusses the main aspects characterizing the dynamics of ethno-demographic development in the Republic of Khakassia. Particular attention is paid to the place and role of miscegenation. The empirical basis of the study was made up of data from all-Russian and regional statistics. It was revealed that in percentage terms the number of representatives of the Khakass ethnos is growing, while in absolute numbers it is decreas-ing. We believe that this is due to demographic, migration, ethno-social (primarily miscegenation) processes. The impact of miscegenation on the development of ethno-demographic processes in Khakassia is multidirec-tional and can have both positive and negative consequences. The study of this issue requires further deepen-ing and expansion, which will allow us to describe in more detail the specifics of the ethnic identity of mestizo people, the attitude towards interethnic marriages on the part of representatives of various national groups, the main social risks associated with miscegenation, in general, to show how the processes of miscegenation in-fluence changes in the sociocultural space of the Republic of Khakassia.
Social Nutrition Practices of High School Students
Authors:   Lipetsk State Pedagogical University named after P.P. Semenov-Tyan-Shansky, Dankovtsev Oleg A.
Published: December 2023

The paper presents the results of an assessment of the social nutrition practices of high school students. The study involved 256 girls and boys aged 15–17 years – students of general education institutions in the city of Lipetsk. The study included: studying the state of the body's supply of nutrients and energy (nutritional status); assessing the risk of developing eating disorders and types of eating disorders; determination of actual food consumption. The data obtained indicate a high prevalence of eating disorders among schoolchildren of the overeating type. It was found that 40,2 % of schoolchildren of both sexes have risky eating behavior. It is shown that the externalized type of eating behavior is more common among high school students, and the restrictive and emotiogenic types are less common. Violations of food consumption by schoolchildren have been re-vealed, which manifest themselves in non-compliance with the food intake regimen, monotonous diet, exces-sive consumption of sugar, confectionery, fatty food, fast food.
Subjective Experience of Loneliness, Existential Fulfillment and Life Satisfaction among University Students
Authors:   Emperor Alexander I St. Petersburg State Transport University (PGUPS), Yashchenko Elena F. , Shchelokova Ekaterina G. ,   Emperor Alexander I St. Petersburg State Transport University (PGUPS), Evdokimova Yuliya S. ,   Emperor Alexander I St. Petersburg State Transport University (PGUPS)
Published: December 2023

The study is devoted to the study of the characteristics of subjective experience of loneliness, existential fulfill-ment and life satisfaction of university students with different levels of subjective experience of loneliness, who are in relationships and those who are not. The sample is represented by students of 2–4 courses of a transport university in the amount of 85 people aged 18 to 24 years (average age 20 years), of which 48 people are in a relationship, 37 are not in a relationship. The results of the comparative analysis made it possible to indicate the differences between the indicators of subjective experience of loneliness, existential fulfillment and life satisfaction in students who are and are not in a relationship, as well as in students with a high and low level of subjective experience of loneliness. The results of the study allow to identify the peculiarities of the formation of the studied psychological phenomena in adolescence.
The legal regulation of artificial intelligence security in Ukrainian banking
Authors: Klochko Alona , Kurylo Mykola , Rohovenko Oleh , Volchenko Nataliia , Shulzhenko Assol
Published: December 2023

The need to expand the range of banking services in Ukraine is stipulated with technological progress, the European integration processes and the legal regime of martial law introduced in the country. Under the conditions of war, the need to strengthen the security of banking activities and protect the banking system from the influence of any internal and external factors gains meaning. The topical direction of economic and legal research of scientists today is the possibility to introduce digital technologies with elements of artificial intelligence (AI) into the banking activity in Ukraine to improve its protection. The AI law as an independent branch of the Ukrainian law has not been developed so far. The sources of AI law, its functions, tasks, scope, risks and limits of legal responsibility for prohibited practices of artificial intelligence have not been defined. The purpose of the article is to analyze the theoretical and legal provisions that underpin the regulation of AI application in Ukrainian banking. The comparative legal method made it possible, considering the provisions of the draft law on AI of the European Union, to determine the trends in the development of the legal regulation of AI in Ukraine. Following the study, proposals to the legislation of Ukraine were formulated, which will contribute to the legal regulation of banking activities using digital technologies with elements of AI.
Carbon dioxide laser ablation for treatment of limbal squamous cell carcinoma in horses
Authors: English Robert V. , Nasisse Mark P. , Davidson Michael G.
Published: December 2023

Limbal squamous cell carcinoma in 4 horses was treated successfully, using carbon dioxide laser ablation. Tumors were removed, with minimal to no postoperative inflammation or discomfort to the horses. Carbon dioxide laser ablation represents a promising new option in the treatment of limbal squamous cell carcinoma in horses.
Prevalence of antithyroglobulin antibodies detected by enzyme-linked immunosorbent assay of canine serum
Authors: Beale Karin Muth , Halliwell Richard E. W. , Chen Chao L.
Published: December 2023

Antithyroglobulin antibody (ata) values were higher in dogs with low total serum thyroxine (T4) and triiodothyronine (T3) values than in dogs with T3 and T4 values within reference value limits. In the population studied, Doberman Pinschers were predisposed to the development of ata; there was no sex predilection for development of ata. Antithyroglobulin antibodies and thyroid status were evaluated in 2 groups of healthy dogs (n = 30) and in 470 canine serum samples submitted for T3 and T4 value determination. Antithyroglobulin antibodies were evaluated by elisa, and thyroid status was evaluated by measurement of total serum T3 and T4 by radioimmunoassay.
Electrolyte abnormalities associated with diarrhea in rhesus monkeys: 100 cases (1986-1987)
Authors: George Jeanne Wright , Lerche Nicholas W.
Published: December 2023

Serum electrolyte values from 100 rhesus monkeys with diarrhea were reviewed. The most frequent finding was hyponatremia (88%), with hypochloremia next most frequently detected (80%). Metabolic acidosis was less common (59%) and usually associated with high anion gap values. Associations between electrolyte abnormalities and age, housing, or case outcome were not found. Bacteriologic culturing was performed on fecal specimens from 90 monkeys. Campylobacter coli or C jejuni alone was isolated from 42 (46.7%) specimens, C coli and Shigella flexneri were isolated from 25 (27.8%) specimens, and S flexneri alone was isolated from 6 (6.7%) specimens. A pathogen was not isolated from 17 (18.9%) specimens. Hyponatremia, hypochloremia, acidosis, and high anion gap values were most severe in monkeys infected with Campylobacter sp, either alone or with concurrent S flexneri infection. Serum sodium concentrations < 132 mEq/L and serum Cl concentrations < 93 mEq/L were consistently associated with Campylobacter sp infection.
Assessment of survey radiography and comparison with x-ray computed tomography for detection of hyperfunctioning adrenocortical tumors in dogs
Authors: Voorhout George , Stolp Ruurd , Rijnberk Ad , van Waes Paul F.G.M.
Published: December 2023

Results of abdominal survey radiography and x-ray computed tomography (CT) were compared in 13 dogs with hyperadrenocorticism histologically attributed to adrenocortical tumors. X-ray computed tomography enabled accurate localization of the tumor in all 13 dogs. Apart from 2 poorly demarcated irregular-shaped and mineralized carcinomas, there were no differences between adenoma (n=3) and carcinoma (n= 10) on CT images. In 1 dog, invasion of the caudal vena cava by the tumor was suggested on CT images and was confirmed during surgery. Suspicion of adhesions between tumors of the right adrenal gland and the caudal vena cava on the basis of CT images was confirmed during surgery in only 2 of 6 dogs.

Survey radiography allowed accurate localization of the tumor in 7 dogs (4 on the right side and 3 on the left). In 6 of these dogs, the tumor was visible as a well-demarcated soft tissue mass and, in the other dog, as a poorly demarcated mineralized mass. The smallest tumor visualized on survey radiographs had a diameter of 20 mm on CT images. Six tumors with diameter ≤ 20 mm were not visualized on survey radiographs. In 1 of these dogs, a mineralized nodule was found in the left adrenal region, without evidence of a mass.

In a considerable number of cases, survey radiography can provide presurgical localization of adrenocortical tumors in dogs with hyperadrenocorticism; CT is redundant in these instances. In the absence of positive radiographic findings, CT is valuable for localization of adrenocortical tumors.
Drug therapy in cats: Recommended dosing regimens
Authors: Boothe Dawn Merton
Published: December 2023

The goal of this series of articles has been to provide a comprehensive review of the literature regarding recommended dosing regimens, therapeutic indications and contraindications, and potential side effects of drugs used in cats. In this fourth and last article, the available information regarding dosage regimens in cats has been consolidated in tabular form to facilitate an effective and rational approach to the pharmacologic prevention and treatment of a variety of feline medical disorders.
Transendoscopic contact neodymium:yttrium aluminum garnet laser correction of epiglottic entrapment in standing horses
Authors: Tulleners Eric P.
Published: December 2023

Fifty-seven Standardbred and 44 Thoroughbred racehorses and 1 Thoroughbred polo mare with primary clinical signs of exercise intolerance or respiratory tract noise or combined exercise intolerance and respiratory tract noise were referred for laser correction of epiglottic entrapment. Significantly (P < 0.001) more Standardbred than Thoroughbred racehorses were affected, compared with the observed hospital population during the same period. At referral, 14 horses did not have evident epiglottic entrapment and were returned to exercise without development of entrapment after treatment, which consisted of 1 week of rest and administration of anti-inflammatory medication.

In 88 standing horses under sedation and topical anesthesia, epiglottic entrapment was corrected transendoscopically by use of a contact neodymium:yttrium aluminum garnet laser. In these 88 horses, 98% of entrapments were persistent, 92% were thick, 97% were wide, and 45% were ulcerated. Thirty-one percent of the horses had endoscopic evidence of epiglottic hypoplasia, and 8% had deviated epiglottic axis.

Complete correction was achieved in 97% of the horses, Persistent dorsal displacement of the soft palate in 1 horse and severe epiglottic hypoplasia with thick, chronic entrapping membranes in 2 horses precluded successful transendoscopic correction with the horses in standing position. Most horses were treated onan outpatient basis, and all were able to be returned to exercise after 7 to 14 days of rest and treatment with anti-inflammatory medication.

Entrapment recurred in 4 horses (5%), 3 of which had hypoplastic epiglottis. Dorsal displacement of the soft palate developed after surgery in 9 horses (10%) and continued in 4 horses (5%) that had displaced soft palate before surgery. All these horses had epiglottic hypoplasia.

Laser correction of epiglottic entrapment in standing horses was safe, well tolerated, and effective. Laser surgery was an alternative to conventional surgery, and eliminated the need for general anesthesia and laryngotomy. It also reduced convalescence and postoperative complications.
Lack of detectable blood groups in domestic ferrets: Implications for transfusion
Authors: Manning Dean D. , Bell Judith A.
Published: December 2023

Evidence of blood groups in domestic ferrets was sought by testing serum samples for naturally acquired or experimentally induced erythrocyte antibodies. All sera were tested for ability to cause direct agglutination, antiglobulin-enhanced (Coombs test) agglutination, or lysis.

Examination of 212 randomly paired combinations of ferret serum and erythrocytes produced no evidence of naturally acquired blood group antibodies. Six pairs of ferrets were reciprocally transfused twice, 34 days apart, with 6-ml quantities of anticoagulated blood. All were tested 21 days after the first transfusion, as well as 10 and 30 days after the second transfusion; erythrocyte antibodies were not detected. Four additional pairs of ferrets were reciprocally inoculated sc with a series of six 1.25-ml quantities of blood in Alsever solution, administered over a 3-week period, and tested 8 days after the last injection; again, erythrocyte antibodies could not be detected.

These observations suggest that blood groups of the kind in human beings and other mammals either do not exist in domestic ferrets or represent antigen systems too weak to elicit measurable responses under the reported conditions. It appears, therefore, that transfusion in this species poses little clinical risk, even without crossmatching.
Economic analysis of an epizootic of pseudorabies and subsequent production following the institution of a vaccination program in a Pennsylvania swine herd
Authors: Parsons T. D. , Pitcher P. M. , Johnstone C.
Published: December 2023

The economic impact of pseudorabies was examined in a commercial swine herd. At the onset of clinical signs, a modified-live virus vaccine was administered to the sow herd and repeated at 3-month intervals. According to production data from the 320-sow farrow-to-feeder unit, preweaning mortality increased twofold, and subsequently, the number of pigs weaned per litter decreased by 19% (P < 0.005) during the 5-week epizootic. Also, the number of pigs born alive decreased by 6% during the epizootic (P < 0.05). No significant differences in production were observed between the 6-month periods before and after the epizootic. Actual cash flow analysis for the farm under isomarket conditions revealed a decreased net return of $2.40/inventoried sow/week, which was attributed to the disease during the epizootic, and a $0.46 decrease in net return/inventoried sow/week in the postepizootic period. Most seropositive herds have clinical signs less severe than those described in this herd, and the cost of eradication of the virus from a swine herd can be in excess of $200/inventoried sow. Thus, we believe that sufficient financial incentives are not available to all swine producers to ensure their enthusiastic cooperation in the effort to eradicate pseudorabies from the US swine population.
Obstructive nephrolithiasis and ureterolithiasis associated with chronic renal failure in horses: Eight cases ( 1981-1987)
Authors: Ehnen S.J. , Divers T.J. , Gillette D. , Reef V.B.
Published: December 2023

Eight adult horses with obstructive nephrolithiasis and/or ureterolithiasis were examined between 1981 and 1987. One horse had bilateral ureteral obstruction at hospital admission; the others had unilateral ureteral obstruction. All horses had similar bilateral renal pathologic findings that were compatible with chronic intermittent or complete obstruction. Horses were referred for evaluation of weight loss, poor performance, and/or decreased appetite. Clinical findings, laboratory results, and/or postmortem findings in all horses supported the diagnosis of chronic renal failure. Age of the 8 horses varied between 2 and 17 years; 5 of the 8 were between 2 and 3 years old. Seven horses were Thoroughbreds and 1 was a Standardbred. Of the horses examined, 4 were females and 4 were males (2 geldings). Diagnosis of obstructive nephrolithiasis and/or ureterolithiasis was made in all of the hospitalized horses based on examination per rectum and/or renal ultrasonographic findings. Surgical removal of the obstructing calculi was performed in one horse. Although etiopathogenesis could not be proven, histopathologic findings in the kidneys of the horses of our study were suggestive of renal failure secondary to obstructive urinary disease.
von Willebrand heterotopic osteochondrofibrosis in Doberman Pinschers: Five cases (1980-1987)
Authors: Dueland R. T. , Wagner S. D. , Parker R. B.
Published: December 2023

Five cases involving female Doberman Pinschers, each with a mass composed of osseous, chondrous, or fibrous tissue, or a combination thereof, formed in or around the muscles of the hip, were reviewed. In each dog, the mass severely limited the coxofemoral joint range or motion, especially when the joint was extended. Surgical debulking resulted in a favorable outcome. All dogs tested had plasma concentrations of von Willebrand factor antigen below established normal limits. We believe that the low concentrations of von Willebrand factor antigen commonly found in Doberman Pinschers may predispose them to the development of this condition and its resulting pelvic limb lameness, presumably because of increased risk of microvascular bleeding. This association is presumptive because 2 dogs in our study had a history of excessive bleeding either before or after being treated for the hip condition. Trauma was associated in 2 cases. All 5 dogs, however, bled more than usual during the curative surgery. These 5 cases, plus additional reported cases, confirm this syndrome, which warrants recognition. The name von Willebrand heterotopic osteochondrofibrosis of Doberman Pinschers was selected because it identified the basic features of the syndrome.
Nutritionally variant streptococci associated with corneal ulcers in horses: 35 cases (1982-1988)
Authors: da Silva Cunei Jeannette M.A. , Murphy Christopher J. , Jang Spencer S. , Bellhorn Roy W.
Published: December 2023

Nutritionally variant streptococci (nvs) are nutritionally deficient viridans streptococci that require pyridoxal for growth. Although nvs are pathogenic in human beings, they have not been considered to be pathogenic in domestic animals. In 1982 and 1983, 24 isolates of nvs were recovered from horses with ulcerative keratitis. A retrospective study was done to determine the incidence of nvs in horses with corneal disease. The medical records of 249 horses (259 eyes) examined for clinical signs of corneal disease were reviewed. Nutritionally variant streptococci were isolated from approximately 13.5% of horses with ulcerative keratitis.
Variable locations of nutrient foramina of the proximal phalanx in forelimbs of Thoroughbreds
Authors: Kneller S. K. , Losonsky J. M.
Published: December 2023

Bilateral metacarpophalangeal radiographs of 100 Thoroughbreds were examined for visualization and location of the major nutrient foramen of the proximal phalanx. The foramina were located on the dorsal or palmar aspects of the cortex or were not visible radiographically. Of the 100 horses, 60 had the same pattern in both forefeet. In the remaining 40 horses, the left and right proximal phalangeal foramina were asymmetric. Of the 200 proximal phalangeal foramina (100 horses), 53 were on the dorsal aspect of the cortex and 101 were on the palmar aspect of the cortex; 46 were not visible radio-graphically. Significant effect of age or gender could not be determined.
Therapeutic value of partial excision of lesions combined with administration of an autogenous vaccine during an episode of cutaneous papillomatosis in cattle of Uganda
Authors: Ssenyonga G. S. Z. , Onapito J. S. , Nakasala-Situma J. , Omara-Opyene A. L.
Published: December 2023

The therapeutic value of partial excision of lesions combined with administration of an autogenous vaccine in calves during an episode of cutaneous papillomatosis was evaluated. Of 10 Holstein calves naturally infected with cutaneous papillomatosis, 5 were given 20 ml of autogenous vaccine in addition to undergoing partial excision of the lesions; the other 5 calves were not given vaccine. Results indicate that partial excision combined with administration of autogenous vaccine has some therapeutic value in calves with small pedunculated papillomas, but not in calves with large confluent lesions.
Taste responses of dogs to ethylene glycol, propylene glycol, and ethylene glycol-based antifreeze
Authors: Marshall David A. , Doty Richard L.
Published: December 2023

Although it is widely believed that ethylene glycol-based antifreeze (af) is an attractive tastant to dogs and other animals, empirical data on this point are not available. In experiment 1, we examined the propensity of 178 adult mixed-breed dogs to approach, sniff, and lick a concentration of af commonly used in automotive cooling systems (50%). Despite the fact that most of the dogs approached and sniffed the af in these 5-minute tests, only 9% initiated lick responses and most of these were brief and not followed by additional licking. In experiment 2, the lick responses of five gastric-cannulated dogs to aqueous solutions of 20% sucrose, 50% ethylene glycol, 50% propylene glycol, water, and 50% af were examined in 14-minute tests before and after periods of food and water deprivation. Under the latter conditions, 2 of the 5 dogs drank amounts of ethylene glycol that would have been lethal to uncannulated dogs. None of the five dogs drank potentially lethal amounts of af. The preference order for these tastants was sucrose > water > ethylene glycol > af = propylene glycol. Although these findings question the general belief that af is highly palatable to most dogs, they do imply that large individual differences in responsiveness exist and that af ingestion is likely influenced by motivational state. Furthermore, they suggest the possibility that unpleasant-tasting additives could be successfully developed to eliminate the ingestion of af, because the initial attractiveness of af is relatively low. Such additives would have to be stable in vehicular cooling systems and not adversely affect the functional aspects of af performance.
Elective cesarean section in mares: Eight cases (1980-1989)
Authors: Watkins J. P. , Taylor T. S. , Day W. C. , Varner D. D. , Schumacher J. , Baird A. N. , Welch R. D.
Published: December 2023

From 1980 to 1989, 8 cesarean sections were performed on an elective basis in 5 mares. Four mares had partially obstructed pelvic canals; 2 of these mares had previously lost foals because of dystocia. Cervical adhesions that might obstruct passage of the fetus through the pelvic canal was suspected in the fifth mare. Cesarean section was performed prior to mares entering the first stage of labor. Readiness for birth was estimated by development of the mare's mammary gland and the presence of colostrum in the udder. A ventral midline celiotomy provided excellent exposure and healed without complications in all instances. Eight viable foals were produced. One foal developed bacterial pneumonia and septicemia after surgery and died. Follow-up evaluation of the 7 foals discharged from the hospital failed to reveal complications associated with elective cesarean section.

All mares survived the procedure. Fetal membranes were retained for up to 72 hours following surgery; however, systemic complications secondary to retained placenta did not develop. Three mares were bred subsequent to elective cesarean sections, with each mare conceiving the year following surgery. Three foals were produced by 1 mare and 2 foals have been produced by another mare by elective cesarean sections.
Clinical use of metronidazole in horses: 200 cases (1984-1989)
Authors: Sweeney Raymond W. , Sweeney Corinne R. , Weiher Janice
Published: December 2023

Case records of 200 horses treated with metronidazole were reviewed. Horses were treated for respiratory tract infections (90 cases), peritonitis or abdominal abscess (39 cases), celiotomy (49 cases), orthopedic infections (6 cases), and miscellaneous soft tissue infections (16 cases). Bacteria of the genus Bacteroides were most prevalent (55 of 167 anaerobic isolates). Metronidazole was always used in combination with other antimicrobial drugs.

Only 4 of the 200 horses had signs of adverse effects associated with metronidazole treatment. Those 4 horses had poor appetite that resolved when metronidazole treatment was discontinued.