bluuebunny/crossref_metadata_2025 huggingface dataset:
Distribution of Rh Subgroups and Kell Antigens in Patients with Thalassemia
Authors: Na’ma Farah K. , Majeed Mahmood H.
Published: December 2022

First-line therapy for thalassemia patients is blood transfusion. Patients who get repeated transfusions of red blood cells (RBCs) risk developing an immune response to the RBCs, resulting in a hemolytic transfusion reaction and even death. Patients who get phenotype blood transfusions are less likely to experience these side effects. Between 2014 and 2015, researchers at Baghdad’s Ibn Al-Baladi Thalassemia Hospital performed a prospective survey and collected samples.
Clinical and metabolic characteristics of males with early-onset androgenetic alopecia
Authors: Vinay Keshavamurthy , Bhattachajee Rajsmita , Bishnoi Anuradha , Kaushik Akanksha , Sachdeva Naresh , Pal Arnab , Narang Tarun , Dogra Sunil
Published: December 2022

Background

Men with early-onset androgenetic alopecia (AGA) often have an abnormal hormonal milieu.

Objective

To ascertain the clinico-phenotypic characteristics and the prevalence of hormonal and metabolic changes in men with early-onset AGA.

Methods

Consecutive male patients less than 30 years of age with a Norwood-Hamilton grade ≥3 AGA were recruited in this comparative cross-sectional study. After endocrine evaluation they were classified into two groups, that is, Group A consisting of subjects with an altered hormonal profile and Group B with normal hormonal profiles. The groups were assessed for differences in disease phenotype and severity (Norwood-Hamilton grade), insulin resistance and parameters of metabolic syndrome (ATP III guidelines).

Results

Altered hormonal profiles were seen in 34 of the 100 subjects with AGA, while insulin resistance and metabolic syndrome were noted in 44 and 26 respectively. Altered hormonal profiles were significantly associated with insulin resistance and severe alopecia (grade 4 and above Hamilton-Norwood Scale). Insulin resistant Group A patients had a significantly higher prevalence of severe alopecia (>grade 4) (P = 0.0036). The prevalence of metabolic syndrome was similar in both groups.

Limitation

The cross sectional study design was a drawback of this study. Further, a control arm without AGA was not included and the sample size of 100 was selected arbitrarily.

Conclusion

An altered hormonal profile and insulin resistance was noted in a third of the males with early-onset AGA. Subjects with altered hormonal profiles had a higher prevalence of insulin resistance and were likely to have severe grades of AGA.
Implicating transforming growth factor-β and sex steroids in the regulation of brain-gonadal functions
Authors: Mamta Sajwan Khatri
Published: December 2022

Transforming growth factor-beta (Tgf-β) significantly mediates TGF signals in the brain and gonadal development. The present study insights into the implication of novel factor Tgf-β and sex steroids in coordination with catecholaminergic activity; moreover, the influence on catecholamines, gonadotropin-releasing hormone (GnRH1), and related transcripts/genes by implanting osmotic pump-mediated mismatches sex steroids in the teleost. The outcome collectively showed the severe effect of estrogenic compounds at the nominal dose over androgenic to alter reproductive conditions. In addition, the differential pattern of key transcription factors/genes revealed significantly higher expression in the brain and gonads than in other organs, which seem to have a role in the hypothalamic-pituitary-gonadal (H-P-G) axis to regulate brain-gonadal functions in catfish. Furthermore, the abundance of crucial factors mRNA and protein expression in the brain suggests a significant role in this correlation. Collectively, the study provides an understanding of the growth factors and sex steroids through dopaminergic system, where upregulated expression levels of GnRH1 vis-a-vis certain brain-related genes, that is, GnRH1, Tgf-β, Gfrα-1, cyp19a1b, tph, and th in teleost revealed their regulatory influence more importantly on the H-P-G axis.
“And the Sharpalniks (Robbers) Came from Pskov”: to the Problem of Relationship between Pskovites and Novgorodians during the Time of Troubles
Authors: Попова Е. М.
Published: December 2022

В данной статье автор исследует взаимоотношения псковичей и новгородцев в период Смуты. Благодаря сохранившемуся богатейшему актовому материалу, хранящемуся в Государственном архиве Швеции и в архиве СПбИИ РАН, удается проследить, что Новгород и Псков, несмотря на свое соседство, в период Смуты представлялись властям обеих территорий как недружественные и отдельные друг от друга. Однако это не мешало простому населению продолжать контактировать - торговать или вести совместные действия противоправного характера. Соответственно, подобная связь считалась преступной и была наказуемой. В связи с чем новгородцы нередко прибегали к тактике «обеления» себя, перекладывая вину на соседних псковичей, которые представлялись преступниками и грабителями, виновными в большинстве разбоев на территории Новгородчины и пограничных землях.

The author of the article explores the relationship between Pskovites and Novgorodians during the Time of Troubles. Thanks to the rich acts data, survived and kept in the National Archives of Sweden and in St. Petersburg Institute of History of RAS, it becomes possible to trace the relationship and find out that Novgorod and Pskov, despite their proximity, during the Time of Troubles were seen by the authorities of both territories as unfriendly and detached from each other. However, this did not prevent the ordinary population from continuation of contacts in trade or joint activity of an illegal nature. Accordingly, such a relationship was considered criminal and was punishable. In this connection, Novgorodians often resorted to the tactics of “whitewashing” themselves, shifting the blame to neighboring Pskovites, who were presented as criminals and robbers (sharpalniks), guilty of most of the robberies in the Novgorod region and its borderlands.
Alexander Semenovich Khvoinsky -the Owner of the Treasure Collection from Excavations 2016 in Pskov
Authors: Яковлев А. В. , Ершова Т. Е.
Published: December 2022

Клад 2016 года - наиболее многочисленное по количеству и составу находок сокровище из числа открытых псковскими археологами в последние десятилетия, да и за всю историю научных раскопок в Пскове. В составе клада главная составляющая - крупная нумизматическая коллекция, коллекция христианской мелкой пластики XII-XIX вв., личные ценности хозяина сокровища - Александра Семеновича Хвоинского (1872 - после 1919) и его семьи. Полное научное описание клада еще не завершено. В статье объясняются обстоятельства находки, приводятся аргументы в пользу определения персоны укрывателя клада, рассматриваются условия его сокрытия и судьбы некоторых обитателей дома, у стены которого клад был обнаружен, публикуются описания некоторых предметов из числа личных вещей семьи.

The treasure of 2016 is the most numerous treasure collection in terms of the number and composition of finds, discovered by Pskov archaeologists in recent decades, and in the entire history of scientific excavations in Pskov. Its main component is a large numismatic collection, a collection of Christian small plastic art of the 12th-19th centuries, personal valuables of the owner of the treasures, Alexander Semyonovich Khvoinsky (1872 - after 1919) and his family. The entire scientific description of the treasures has not yet been completed. The article explains the circumstances of the find, provides arguments in favor of identifying the person who had hid the treasure, considers the conditions for its concealment and the fate of some inhabitants of the house, near the wall of which the treasure was discovered, and publishes descriptions of some items of the family's personal belongings.
Cultural Deposits of Medieval Novgorod and Artifact Chronologies
Authors: Петров М. И.
Published: December 2022

Статья затрагивает вопросы формирования культурного слоя средневекового Новгорода в свете его стратиграфических особенностей для построения хронологии новгородских древностей. Историографический обзор существующих к настоящему времени вещевых хронологий показывает их комплексный характер: разработки опираются на стратиграфический метод датирования и сравнительнотипологические штудии, но при этом привязаны к абсолютной хронологии ярусов раскопа, основанной на новгородской дендрохронологической шкале. Большинство существующих вещевых хронологий разработаны или уточнены в 1980-х гг., что позволяет поставить вопрос об их современной коррекции, но единственно верный путь лежит в повторении исследовательской логики их разработчиков.

The article deals with artifact chronologies of medieval Novgorod in the light of modern knowledge on formation of cultural deposits. Chronologies of Novgorod antiquities have complex characteristic: they are based on stratigraphic methods and typological studies but have absolute dates made by dendrochronology. The majority of actual artifact chronologies developed or were corrected in the 1980 s, thus, they need to be revisited according to modern data. The only way of this is to repeat research logic of their developers.
Cases of Sinusitis among the Population of Polotsk in the 13th-18th Centuries
Authors: Грицкевич Д. С.
Published: December 2022

Представлены результаты палеопатологического исследования остеологического материала из археологических памятников города Полоцка: Нижний замок (XIII-XIV, XVII-XVIII вв.), Спасо-Преображенский храм (XII-XVIII вв.), Полоцкое городище (XVII-XVIII вв.), Великий посад (XVII-XVIII вв.), Доминиканский монастырь (XVII-XVIII вв.), Заполотский посад (XVII в.). Цель исследования - выявление среди городского населения следов воспаления верхнечелюстных пазух (синусит). В результате анализа остеологического материала было зафиксировано 13 случаев заболевания. Следы воспалений были выявлены у 7 мужчин, 5 женщин и на остеологическом материал одного индивида, пол которого установить не удалось. Согласно возрастному разделению, заболевание чаще фиксировалось у индивидов от 20 до 30 лет (5 случаев), далее - у индивидов в возрасте 50+ (4 случая), в возрасте от 30 до 40 и от 40 до 50 лет было выявлено по 2 случая. В двух случаях удалось показать причины возникновения заболевания (травматогенная и одонтогенная). В остальных же установление этиологии заболевания оказалось затруднительным.

The results of a paleopathological study of osteological material from the archaeological sites of the city of Polotsk are presented: the Lower Castle (XIII-XIV, XVII-XVIII centuries), the Church of the Transfiguration of the Savior (XII-XVIII centuries), the Polotsk Gorodische (XVII-XVIII centuries), Veliky Posad (XVII-XVI-II centuries), Dominican monastery (XVII-XVIII centuries), Zapolotsky Posad (XVII century). The aim of the study was to identify traces of inflammation of the maxillary sinuses (sinusitis) among the urban population. The analysis of osteological material revealed 13 cases of the disease. Traces of inflammation were found on the osteological material of 7 men, 5 women, and one individual, the sex of whom appeared impossible to be determined. According to the age classification, the disease was more often recorded in individuals aged 20 to 30 years (5 cases), then in individuals aged 50+ (4 cases), and in those, aged 30 to 40 and 40 to 50, 2 cases were detected. In two cases, it became possible to identify the causes of the disease (traumatic and odontogenic). In the other cases, the establishment of the etiology of the disease proved to be difficult.
New Materials from the Kurgan Group near the Village of Kalikhnovshchina and its Surroundings in Gdov Region
Authors: Михайлова Е. Р. , Соболев В. Ю.
Published: December 2022

Статья вводит в научный оборот ряд новых находок с территории курганно-жальничного могильника близ д. Калихновщина Гдовского района. Анализируемые находки распадаются на две хронологические группы, одна из которых относится к Средневековью и связана с функционированием курганно-жальничного могильника, другая представляет собой несколько железных изделий первых веков н. э. Рассматривается также возможность существования рядом других археологических памятников.

The article introduces a number of new finds from the territory of the kurgan-zhalnik burial ground near the village of Kalikhnovshchina, Gdov region. The analyzed finds fall into two chronological groups, one of which dates back to the Middle Ages and is associated with the functioning of the kurgan-pit burial ground, and the other represents several iron items dated by the first centuries AD. The possibility of the existence of a number of other archaeological sites in the neighborhood is also being considered.
Amber Crosses of the 16-18 Centuries in Pskov in the Context of Travelers' Testimonies
Authors: Колпакова Ю. В.
Published: December 2022

В статье ставится вопрос о возможности датирования группы янтарных крестов из раскопок в Пскове периодом позже XV века. Приводится обзор янтарных крестов с поздними датировками из музейных собраний России. Автор делает попытку выявить комплекс типологических признаков, свойственных янтарным нательным крестам позднего Средневековья - Нового времени: 1) трапециевидные, расширяющиеся к концам лопасти; 2) завершение одной из вертикальных лопастей углом (ромбовидная лопасть); 3) изображение креста на Голгофе с монограммами; 4) завершение лопастей в виде трех закруглений.

The article considerers possibility of dating a group of amber crosses from excavations in Pskov to the period later than 15 century. An overview of late dated amber crosses from museum collections in Russia is given. The author tries to identify a set of typological features characteristic of amber pectoral crosses of the late Middle Ages - Early modern period. They are 1) trapezoid, widening towards the ends of the cross; 2) diamondshaped, ending one of the vertical bars with an angle; 3) image of the Golgotha cross with monograms; 4) with the bars of the cross, ending in the form of three roundings.
Danish and English: Language Policy within the context of Danish Education System
Authors: Волков Ю.А. , Савельева М.Н. , Пашковская Н.Д. , Дронова Н.А.
Published: December 2022

В статье рассматривается политика применения английского языка как языка обучения (EMI) в контексте высшего образования Дании. Один из вопросов заключается в важности концепции образования на родном языке в Дании. С какими трудностями сталкиваются датчане, не говорящие поанглийски, в отношении использования английского языка в высших учебных заведениях и как можно решить такие проблемы. Материалы и методы. Авторы анализируют различные позиции в национальных дебатах по языковому вопросу в Дании и рассматривают отношение к этим позициям среди датчан. Результаты. Результаты показывают, что политика EMI, по-видимому, привела, в целом, к более или менее положительным результатам, считается, что датчане обычно хорошо владеют английским языком, вплоть до того, что их позиционируют как двуязычных граждан, и отношение к английскому языку в целом позитивное по всей стране. Однако в последние годы все более широкое использование английского языка в высшем образовании стало предметом дискуссий в Дании. В этом исследовании излагаются различные позиции в национальных дебатах в Дании, и исследуется отношение к этим позициям среди датчан. Вывод. Основываясь на представленных фактах, авторы приходят к выводу, что исход процесса интернационализации в обозримом будущем пока не ясен. Учитывая недавние политические решения по языковому вопросу, в интернационализации датского высшего образования могут произойти значительные изменения.

Purpose of work. The article examines the English medium instruction (EMI) policy within the context of Danish higher education. One question is the importance of a concept of mother tongue education in Denmark. What difficulties Danes, as non-English speakers, have in regard to the use of the English language in higher education and how such challenges can be addressed. Materials and methods. The author analyzes the various positions in the national debate upon the language issue in Denmark, and then examines the attitudes towards these positions among Danes. Results. The results indicate that, the EMI policy seems to have produced, in general, more or less positive outcomes , Danes are usually considered to be highly proficient in English, to the point of being deemed bilingual, and the attitude towards English is generally positive across the nation. However, The increasing use of English in higher education has been the subject of debate in Denmark over the last years . This study sets out the various positions in the national debate in Denmark, and then examines the attitudes towards these positions among Danes. Conclusion. Based on the facts provided, the author concludes that the outcome of the internationalization process in the foreseeable future is not yet clear. Given the recent policy decisions on the language issue, there could be significant changes in the internationalization of Danish higher education.
Possibilities of stratification of managerial competencies of oilfield service enterprises
Authors: Нурутдинов М.Р. , Хуснуллин Ш.Р.
Published: December 2022

В первые десятилетия ХХІ века в координатах менеджмента под влиянием ряда факторов произошли масштабные и глубокие преобразования. Прорывные технологии, инновационные бизнесрешения, геополитические и демографические изменения отразились на трансформациях управленческих механизмов государственного сектора национальных экономик и существенно усилили динамизм бизнес-пространства. Толчком к новой гибкости и адаптивности в менеджменте стал режим санитарно-эпидемиологических ограничений, введенный из-за распространения коронавирусной инфекции COVID-19, что обусловило переформатирование системы деловых коммуникаций и привнесло ряд инноваций в организации деятельности субъектов всех без исключения сегментов, сфер и отраслей на разных уровнях – от глобального до микроэкономического. Масштабные и содержательные трансформации стали нынешней реальностью, в рамках которой формируются новые императивы, появляются новые возможности, возникают новые риски и угрозы для эффективного менеджмента. Эффективность менеджмента - это в первую очередь проекция компетентности менеджеров различных уровней управления, функциональных сфер и бизнес-процессов. Именно способность продуцировать и воплощать в жизнь инновационные управленческие решения, направленные на обеспечение и поддержку функционирования компаний, предприятий, организаций в условиях новых вызовов со стороны как внешней, так и внутренней среды становится одной из предпосылок эффективного управления.

In the first decades of the XXI century, large-scale and profound transformations took place in the coordinates of management under the influence of a number of factors. Breakthrough technologies, innovative business solutions, geopolitical and demographic changes have affected the transformations of the management mechanisms of the public sector of national economies and significantly increased the dynamism of the business space. The impetus for new flexibility and adaptability in management was the regime of sanitary and epidemiological restrictions imposed due to the spread of COVID-19 coronavirus infection, which led to the reformatting of the business communications system and introduced a number of innovations in the organization of the activities of subjects of all segments, spheres and industries at different levels - from global to microeconomic. Large-scale and meaningful transformations have become the current reality, within which new imperatives are being formed, new opportunities are emerging, new risks and threats to effective management are emerging. The effectiveness of management is primarily a projection of the competence of managers at various levels of management, functional areas and business processes. It is the ability to produce and implement innovative management solutions aimed at ensuring and supporting the functioning of companies, enterprises, organizations in the face of new challenges from both the external and internal environment that becomes one of the prerequisites for effective management.
Dynamic model of the educational system at the enterprises of the oil refining industry
Authors: Бычков В.А. , Бычков С.А. , Журихина А.В.
Published: December 2022

Необходимым условием интеграции национальной системы образования в международное образовательное пространство является качество предоставления образовательных услуг. Любое учреждение общего среднего образования должно позиционировать себя на рынке образовательных услуг путем повышения качества образования и формирования у потребителей умения самостоятельно приобретать знания в течение жизни. Именно это обеспечит становление образования как социальной ценности. Качественное образование рассматривается как один из индикаторов высокого качества жизни, инструмент социального и культурного согласия и экономического роста. Качество образования - соответствие результатов обучения требованиям, установленным законодательством, соответствующим стандартом образования и/или договором о предоставлении образовательных услуг. Обеспечение качества предоставления образовательных услуг в учреждении образование сегодня является самым актуальным вопросом. Это связано с тем, что условия, в которых функционируют и развиваются учебные заведения – это непростые условия рыночных отношений, в которых каждое заведение должно занять определенное место на рынке образовательных услуг. Развитие учебного заведения в таких условиях происходит через конкурентоспособность и успешное позиционирование на рынке.

A necessary condition for the integration of the national education system into the international educational space is the quality of the provision of educational services. Any institution of general secondary education should position itself in the market of educational services by improving the quality of education and forming the ability of consumers to acquire knowledge independently during their lifetime. This is what will ensure the formation of education as a social value. Quality education is considered as one of the indicators of a high quality of life, an instrument of social and cultural harmony and economic growth. The quality of education is the compliance of learning outcomes with the requirements established by law, the relevant standard of education and/or the agreement on the provision of educational services. Ensuring the quality of the provision of educational services in the institution of education today is the most pressing issue. This is due to the fact that the conditions in which educational institutions operate and develop are difficult conditions of market relations, in which each institution must take a certain place in the market of educational services. The development of an educational institution in such conditions occurs through competitiveness and successful positioning in the market.
Higher education in the structure of intellectual potential: state and prospects of development
Authors: Гилязетдинова А.Р. , Афанасьев Н.С.
Published: December 2022

Сегодня высокоразвитые государства мира убедительно демонстрируют, насколько важна система высшего образования для осуществления структурных преобразований и инновационного развития. Высшее образование как феномен социокультурной реальности имеет огромные потенциальные возможности для сохранения и накопления знаний, духовных ценностей и достижений национальной культуры, она играет ведущую роль в идентификации общества и являются движущей силой экономического развития любого государства. В условиях построения знаниевой экономики интеллектуальный потенциал определяется уровнем развития образовательной и научной сфер, состоянием культурного и духовного наследия, ведь в его основе заложена естественная способность аккумулировать все новые знания, генерировать новые идеи, которые становятся основным источником экономического роста. Высшее образование, что является базовым элементом интеллектуального потенциала, отвечает за состояние образованности общества, его способность к развитию и самосовершенствованию. Высшее образование выступает не только носителем интеллектуального потенциала, но и высокопроизводительной силой в обществе и требует постоянного внимания со стороны государства и надлежащей финансовой поддержки. Исследователями образовательной сферы доказано, что соотношение расходов на образование к экономическому эффекту от него составляет 1:4.

Today, the highly developed countries of the world convincingly demonstrate how important the higher education system is for the implementation of structural transformations and innovative development. Higher education as a phenomenon of socio-cultural reality has huge potential opportunities for the preservation and accumulation of knowledge, spiritual values and achievements of national culture, it plays a leading role in the identification of society and is the driving force of economic development of any state. In the conditions of building a knowledge economy, intellectual potential is determined by the level of development of educational and scientific spheres, the state of cultural and spiritual heritage, because it is based on the natural ability to accumulate new knowledge, generate new ideas that become the main source of economic growth. Higher education, which is a basic element of intellectual potential, is responsible for the state of education of society, its ability to develop and self-improvement. Higher education is not only a carrier of intellectual potential, but also a high-performance force in society and requires constant attention from the state and adequate financial support. Researchers of the educational sphere have proved that the ratio of education costs to the economic effect of it is 1:4.
Pedagogical technologies for the implementation of technosphere safety provisions at enterprises
Authors: Сегал М.С. , Куц А.В. , Фирсов В.С.
Published: December 2022

Осознанное восприятие важности гуманистически ориентированных личностных качеств человека и соответствующее формирование качественно нового уровня профессиональных компетенций студентов педагогических специальностей возможно лишь при условии понимания ими целостной картины мира и причинно-следственных связей развития и бытия общества. Фрагментарное мышление, упрощенное понимание человека, репродуктивное обучение, авторитарное воспитание, – эти и другие проблемы современной образовательной системы свидетельствуют о ее консерватизме. Несмотря на провозглашенные лозунги о самоценности личности, важность максимального раскрытия ее потенциала, традиционное образование остается заложницей сложившихся стереотипов, когда знания, умения и навыки формируются “массово”, без учета психофизиологических особенностей человека и важнее опыт творческой деятельности. Техносферное образование-природоориентированный процесс обучения и воспитания, который приносит человеку удовольствие, стремление активно овладевать знаниями, а также осознание потребности в собственном развитии, что выводит на путь целенаправленного самосовершенствования. Главная задача образования с точки зрения ноосферной концепции – формирование у человека целостной техносферного сознания (целостного мышления, этического биоадекватного метода поведения и экологического мировоззрения).

A conscious perception of the importance of humanistically oriented personal qualities of a person and the corresponding formation of a qualitatively new level of professional competencies of students of pedagogical specialties is possible only if they understand the holistic picture of the world and the cause-and-effect relationships of the development and existence of society. Fragmentary thinking, simplified understanding of man, reproductive education, authoritarian upbringing – these and other problems of the modern educational system testify to its conservatism. Despite the proclaimed slogans about the self-worth of the individual, the importance of maximizing its potential, traditional education remains hostage to the prevailing stereotypes, when knowledge, skills and abilities are formed “massively”, without taking into account the psychophysiological characteristics of a person and the experience of creative activity is more important. Noospheric education is a nature-oriented learning and upbringing process that brings pleasure to a person, the desire to actively acquire knowledge, as well as awareness of the need for their own development, which leads to the path of purposeful self-improvement. The main task of education from the point of view of the noospheric concept is the formation of a holistic noospheric consciousness in a person (holistic thinking, ethical bioadaptive method of behavior and ecological worldview).
Marine biogenic emissions of benzene and toluene and their contribution to secondary organic aerosols over the polar oceans
Authors: Wohl Charel , Li Qinyi , A. Cuevas Carlos , P. Fernandez Rafael , Yang Mingxi , Saiz-Lopez Alfonso , Simó Rafel
Published: December 2022

Natural processes in the polar oceans lead to emission of a variety of reactive gases contributing to atmospheric chemistry and aerosol formation. The identity and air–sea fluxes of most of these gases are poorly characterized, bringing uncertainty to the assessment of pre-industrial aerosol sources. Here we present seawater and atmospheric measurements of benzene and toluene in the open Southern Ocean and the Arctic marginal ice zone. Our data suggest a marine biogenic source for these two compounds, which have typically been associated with anthropogenic pollution. Calculated average emission fluxes were 0.024 and 0.037 μmol m-2 d-1 for benzene and toluene, respectively. Including the observed emissions in a chemistry–climate model increased secondary organic aerosol mass concentrations only by 0.1–1.2 % over the Arctic but by 7.7–77.3 % over the Southern Ocean far from continental sources. Climate models must consider the hitherto overlooked emissions of biogenic benzene and toluene from pristine oceanic regions.
Inkjet Printing of All Aqueous Inks to Flexible Microcapacitors for High-Energy Storage
Authors: Che Junjin , Zakri Cécile , Bronchy Maxime , Ly Isabelle , Neri Wilfrid , Poulin Philippe , Yuan Jinkai
Published: December 2022

Due to the low energy density of commercial printable dielectrics, printed capacitors occupy a significant printing area and weight in fully printed electronics. It has long remained challenging to develop novel dielectric materials with printability and high energy-storage density. Here, we present the inkjet printing of all aqueous colloidal inks to dielectric capacitors composed of carbon nanotube electrodes and polyvinylidene fluoride (PVDF)-based dielectrics. The formulated dielectric ink is composed of PVDF latex particles coated by protonated chitosan molecules. Beyond the isoelectric point, the ink demonstrates excellent printability and film-forming properties. Chitosan serves as a strong binder to largely improve the printed film quality yet it introduces charged species. To confine the transport of these mobile charges, the printed PVDF@Chitosan layer was interlayered by a boron nitride nanosheet nanolayer. This layer is perpendicular to the electric field and serves as an efficient barrier to block the transport and the avalanche of charges, eventually leading to a recoverable energy density of 15 J/cm3 at 610 MV/m. This energy density represents the highest value among the waterborne dielectrics. It is also superior to most of the state-of-the-art printed dielectric materials from solvent-based formulations.
Structurally Simple Osmium(II) Polypyridyl Complexes as Photosensitizers for Photodynamic Therapy in the Near Infrared
Authors: Mani Asma , Feng Tao , Gandioso Albert , Vinck Robin , Notaro Anna , Burckel Pierre , Saubaméa Bruno , Blacque Olivier , Cariou Kevin , Belgaied Jamel-Eddine , Chao Hui , Gasser Gilles
Published: December 2022

Five osmium(II) polypyridyl complexes of the general formula [Os(4,7-diphenyl-1,10-phenanthroline)2L]2+ were synthesized as photosensitizers for photodynamic therapy by varying the nature of the ligand L. Thanks to the pronounced π-extended structure of the ligands and the heavy atom effect provided by the osmium center, these complexes exhibit a high absorption in the near infrared (NIR) region (up to 740 nm), unlike related ruthenium complexes. This led to promising phototoxicity in vitro against cancer cells cultured as 2D cell layers but also in multicellular tumor spheroids upon irradiation at 740 nm. The complex [Os(4,7-diphenyl-1,10-phenanthroline)2(2,2’-bipyridine)]2+ was found to be the most efficient against various cancer cell lines, with high phototoxicity indexes. Experiments on CT26 tumor-bearing BALB/c mice also indicate that the Os(II) complexes could significantly reduce tumor growth under 740 nm laser irradiation. The high phototoxicity in the biological window of this structurally simple complex makes it a promising photosensitizer for cancer treatment.
Dimerization/elimination of β-styrylmalonates under action of TiCl4
Authors: Borisov Denis , Chermashentsev Grigory , Potapov Konstantin , Novikov Roman , Tomilov Yury
Published: December 2022

A new type of dimerization of dimethyl (β-styryl)malonates in the presence of TiCl4 accompanied by elimination of a methanol molecule was discovered. Selective methods for the synthesis of substituted trimethyl 4-hydroxy-[1,1´-biaryl]-3,3,5(2H)-tricarboxylates and trimethyl 7-hydroxy-9,10-dihydro-5,9-methanobenzo[8]annulene-6,8,8(5H)-tricarboxylates were developed. The regularities of the occurring processes were determined and a similar reaction of β-styrylmalonate with benzylidenemalonate in the presence of TiCl4 was performed in the scope of the suggested mechanism.
Assigning 1H Chemical Shifts in Paramagnetic Mono and Bimetallic Surface Sites using DFT: a Case Study on the Union Carbide Polymerization Catalyst
Authors: Nobile Anna Giorgia , Trummer David , Berkson Zachariah J. , Wörle Michael , Copéret Christophe , Payard Pierre-Adrien
Published: December 2022

The Union Carbide (UC) ethylene polymerization catalyst, based on silica-supported chromocene, is one of the first industrial catalysts prepared by surface organometallic chemistry, though the structure of the surface sites remains elusive. Recently, our group reported that monomeric and dimeric Cr (II) sites as well as Cr(III) hydride sites are present and that their proportion varies as a function of the Cr loading. While 1H chemical shifts extracted from solid-state 1H NMR spectra should be diagnostic of the structure of such surface sites, unpaired electrons centered on Cr atoms induce large paramagnetic 1H shifts that complicate NMR analysis. Here, we implement a cost-efficient DFT methodology to calculate 1H chemical shifts for antiferromagnetically coupled metal dimeric sites using a Boltzmann-averaged Fermi contact term over the population of the different spin states. This method allowed us to assign the 1H chemical shifts observed for the industrial-like UC catalyst. The presence of monomeric and dimeric Cr(II) sites as well as a dimeric Cr(III)-hydride site was confirmed and their structure was clarified.
A Comparison of Key Features in Melting Point Prediction Models for Quinones and Hydroquinones
Authors: Ganapathi Devi , Akinlemibola Wunmi , Baclig Antonio , Penn Emily , Chueh William
Published: December 2022

Quinones and hydroquinones are small organic molecules with numerous applications: battery electrolytes, pharmaceuticals, sensors, to name a few. An understanding of their fundamental properties, such as melting points, is essential to incorporate these compounds into relevant technologies. In this study, two different approaches were investigated to predict the melting points of quinone and hydroquinone-based molecules. In the first approach, molecular features were calculated with the Mordred molecular descriptor calculator and used to train a ridge regression and a random forest machine learning (ML) model. In the second, a simpler featurization that captures key enthalpic and entropic descriptors was applied in three model variants - a thermodynamic model, a ridge regression model, and a random forest model. The Mordred-calculated features in the ridge regression model outperformed the thermodynamic features across all models for the quinone dataset (average absolute errors (AAE): 29.5 °C), but the thermodynamic features in the thermodynamic model resulted in lower prediction errors for the hydroquinone dataset (AAE: 35.4 °C). These results emphasize the importance of including intermolecular interaction descriptors, especially for classes of molecules in which these interactions are expected to be strong (e.g. hydrogen bonding in hydroquinones). As a byproduct of this study, we also consolidate (from previously published data) four new datasets with quinone and hydroquinone melting points and other key features.
Unusual Foreign Bodies in Gastrointestinal Tract – A Case Series
Authors: GR Chandrashekar , RM Aravind
Published: December 2022

Foreign body ingestion is one of the commonest presenting complaints in emergency department throughout the world. Majority of foreign bodies will be expelled spontaneously or can be removed endoscopically but only a few require emergency surgical removal.Majority of foreign body ingestions are encountered in pediatric age group elderly and individuals with psychiatric illness being the next common group. We present here three cases of foreign body ingestion in unusual circumstances.
Evaluation of Antioxidant Interactions in Combined Standardized Extracts of Tinospora Cordifolia (Willd), Terminalia Arjuna (Roxb) and Ocimum Sanctum (LINN)
Authors: Savant Chetan , Kulkarni Venkatrao , Habbu Prasanna , Kulkarni Preeti , Majeed Muhammed , Nayak Mahadeva
Published: December 2022

Generation of reactive oxygen species ROS occurs in the normal cell during metabolism in animals. Over production of ROS in the animals causes oxidative stress that leads to oxidative DNA damage which is implicated in the pathogenesis of numerous diseases. Since antioxidant mechanism plays vital role in the pharmacotherapy of different disorders the present investigation aims to check the synergisticantagonistic antioxidant effects of standardised extracts of Tinospora cordifolia Willd TCE Terminalia arjuna Roxb TAE Ocimum sanctum Linn OSE in combinations by DPPH Scavenging Activity hydroxyl radical scavenging activity reducing power assay. In all the methods the extract combinations exhibited good scavenging activity. Reaction of combination of standardized extracts with 22 Diphenyl -1-picryl hydrazyl DPPH radicals showed better scavenging activity compared to individual extracts. The IC50 values for TCETAE TCEOSE TAEOSE were found to be 74.12 microg ml 78.62 microg ml and 71.70 microg ml respectively. The IC50 values for hydroxyl radical scavenging activity of different herb combinations viz. TCETAE TCEOSE TAEOSE were found to be 320.28 microgml 340 microgml and 261 microgml respectively. Further the standardized herb combinations showed more effective reductive ability when compared to that of individual standardized herbal extract. Hence it may be concluded that standardized extracts containing potent antioxidant constituents like phenolics flavonoids triterpenoids alkaloids steroids tannins showed synergistic antioxidant activity.nbsp
Hepatoprotective Potential of Endophytic Aspergillus Niger Strain A6 Fractions Isolated from Phyllanthus Amarus Schum and Thonn
Authors: Kishor Puri Smita , Vasantrao Habbu Prasanna , Venkatrao Kulkarni Preeti , Hanmanthrao Kulkarni Venkatrao
Published: December 2022

Aim To isolate characterize and screen for the in vitro antioxidant and hepatoprotective effects of P1EA and P1nB extracts from the endophytic fungi Aspergillus niger strain A6 PALF-1 isolated from leaves of Phyllanthus amarus in paracetamol induced hepatotoxicity.Materials and methods PALF-1 was isolated from Phyllanthus amarus leaves by standard procedures. Chloroform P1C ethyl acetate P1EA and n-butanol P1nB extracts were drawn up. P1C P1EA and P1nB were screened for in vitro antioxidant activity against 2 2-diphenyl-1-picrylhydrazyl DPPH hydroxyl radical followed by reducing power assay. P1EA 50 and 100 mgkg b. w. and P1nB 50 and 100 mgkg b. w. were screened for hepatoprotective activity against paracetamol model in rats. High performance thin layer chromatography HPTLC profile of P1EA and P1nB was also studied. Characterization of PALF-1 was done by polymerase chain reaction PCR sequential analysis.Results P1EA and P1nB found to scavenge DPPH hydroxyl radicals and also showed reductive ability. In animal studies administration of paracetamol 2 gmkg b. w. significantly increased the levels of liver biochemical marker enzymes in comparison to normal group. A marked decrease in the levels of superoxide dismutase SOD and catalase CAT was also observed. Administration of P1EA and P1nB 50 amp100 mg kg significantly reduced the actions of paracetamol by lowering the levels of serum biochemical parameters at various significance levels plt0.001 plt0.01 increasing the levels of SOD and CAT plt0.001 and decreased lipid peroxidation LPO. rDNA PCR sequencing analysis phylogenetic and molecular studies of PALF-1 confirmed the endophytic fungus as Aspergillus niger strain A6. HPTLC finger printing of P1EA and PnB showed the presence of polyvalent compounds.Conclusion P1EA and P1nB fractions of Aspergillus niger strain A6 showed significant antioxidant and hepatoprotective activity in paracetamol induced hepatotoxicity. This may be attributed to the antioxidant principles present in P1EA and P1nB which need to be explored.
A New RP-HPLC Method for Determination of Roflumilast in Bulk and Pharmaceutical Dosage Forms
Authors: K Manogna , HG Akkamma , Sreedhar Chandanam , Rao T Sreenivasa , Biswa Saikia Himanta
Published: December 2022

Background Rofumilast drug estimation was done earlier by spectroscopic methods. Only few chromato graphic studies were reported. Objective Development and validation of RP-HPLC method for the drug Roflumilast by using various chromatographic parameters. Methodology RP-HPLC method was developed with 1 mlmin as flow rate and 10 microl was set as volume of injection for about 15 minutes of run time. Various parameters like accuracy linearity precision were validated for the method as per ICH guidelines.Results UV detection for maximum wavelength at 250 nm with mobile phase of 3070 ratio of Trifluroacetic acid pH 3.2 Acetonitrile showed the retention time of 2.317 min. Conclusion The proposed RP- HPLC method was found to be rapid simple precise accurate and economic forestimation of roflumilast in bulk and pharmaceutical formulations.
New Analytical RP-HPLC Method Development and Validation for the Estimation of Prucalopride in Bulk and Pharmaceutical Dosage Form
Authors: Sreedhar Chandanam , K Manogna , Rao T Sreenivasa , HG Akkamma , Jyoti Krishna Boruah Bidyut
Published: December 2022

Background Prucalopride drug estimation was reported previously by UV spectroscopy methods and few HPLC methods with retention time 4.73 min as per literature survey. Aim of study A new analytical RP- HPLC method development and validation for bulk and pharmaceutical dosage forms of Prucalopride drug with less retention time than reported methods.Methodology The separation was carried out by using RP-HPLC with the mixture of 0.1 orthophosphoric acid methanol in ratio of 3070 vv as mobile phase. The mobile phase at a flow rate of 1 mLmin was pumped and UV detection was found at 225 nm.Results The selected chromatographic conditions gave retention time at 1.5 min for Prucalopride. Conclusion This developed method was validated for precision accuracy linearity robustness as per International Conference of Harmonization ICH guidelines.
Assessment of Adaptogenic Potential of Tecoma stans
Authors: Kulkarni Savita , HM Nanjappaiah , H Shivakumar , Patil VP , Naikwadi Akram , VM Chandrashekhar
Published: December 2022

Background In the traditional therapeutic method different parts of Tecoma stans have been mentioned to be helpful in a variety of neurological diseases.Aim The current research was designed to screen adaptogenic potential of flower extract of Tecoma stans.Methods Anoxia drowning and immobilization stress models.Results The graded doses of methanolic extract of Tecoma stans flower revealed significant adaptogenic activity. Rats pretreated for ten days with methanolic extract of Tecoma stans flower exhibited significant improvement in all the biochemical parameters.Conclusion The extract of Tecoma stans flowers showed significant antistress activity in all the three animal models.
Pharmacognostical Evaluation and In vitro Cytotoxic Activity of Alcoholic and Aqueous Extracts of Corm of Amorphophallus paeoniifolius (Dennst)
Authors: Avadhoot Shastry Rajesh , Karur Naveen , Habbu PrasannaVasantrao , Daniel Madagundi Smita , Sangangouda Patil Basavaraj , Hanumanthrao Kulkarni Venkatrao
Published: December 2022

Background Cancer is an abnormal growth of cells that can arise in any part of the body and causes death. It affects more than one-third in the world and is 20 higher in all fatalities. Tobacco viral infection chemicals radiation etc. causes cancer. Several cancer treatments include surgery chemotherapy and radiotherapy.Objective In this investigation a corm of Amorphophallus paeoniifolius AP was evaluated for pharmacognostical preliminary phytochemical investigation and curative effect of aqueous extract of Amorphophallus paeoniifolius APA and alcoholic extract of Amorphophallus paeoniifolius APE corm for in vitro anti-cancer activity.Methodology In the present study breast cancer cancer of prostate and cancer of cervical human cell lines were used by using MTT SRB and Trypan blue methods followed by their histopathological studies.Results The pharmacognostical studies helps in authentication and identification of plant. The results of cytotoxicity studies of aqueous extract of corm of AP revealed significant cytotoxic properties as compared to alcoholic extract and control group against breast carcinoma prostate carcinoma carcinoma of cervical cell lines in all the tested in vitro anti-cancer models with CTC50 value gt 500 mugmL. The inhibition depends on the increase in concentration of crude extracts and attains linearity till it reaches CTC50 value.Conclusion From the results we can conclude that aqueous and alcoholic extracts of corm of plant can be employed in treatment of various cancer diseases.
Formulation and InVitro Evaluation of Topical Gel for the Treatment of Fungal Infections
Authors: Narayan Yadav Lalit , Nagasree K. , Kumar Sah Sanjay
Published: December 2022

Conventional dosage structures are essentially being considered for the therapy of an intense infection or constant sickness. Nonetheless the significant downside is dose structure must be taken over and over to accomplish remedially viable reach coming about change in plasma drug levels. Subsequently to beat the issues related with ordinary measurements structure controlled medication conveyance framework has been presented.The basic concept behind the development of conventional drug delivery system is to increase pharmacokinetic and pharmacodynamics of drug molecule either by using different approaches or modifying molecular structure. This article provides better understanding of how the topical gel penetrates through the skin to treat infections. Topical gel the most promising novel drug delivery system has qualitative influence on the skin permeation and release of drug having poor rate of absorption through skin layers. Various types of topical gels as well as its benefits and faults have been discussed. Bifonazole is a subbed imidazole antifungal specialist belonging to BCS Class IV sedate having low solvency and low porousness. Bifonazole shows wide range of action against dermatophytes molds yeasts dimorphic organisms and some gram-positive microorganisms. It is a profound lipophilic medication with a short half-life 1-2 h and is insignificantly ingested following dermal application 0.6 of an applied portion.