bluuebunny/crossref_metadata_2025 huggingface dataset:
G-quadruplex Binding Protein Developed using the RGG Domain in TLS/FUS Inhibits Transcription of c-myc
Authors: Ulum Luthfi Lulul , Yagi Ryota , Kawashima Tomoe , Oyoshi Takanori
Published: April 2022

The G-quadruplex structure in the genome is an important drug target because it regulates gene expression and the genome structure. Several small molecules that bind the G-quadruplex have been developed, but few artificial G-quadruplex binding proteins have been reported. We previously reported a novel G-quadruplex DNA binding protein (RGGF) engineered using the Arg-Gly-Gly repeat (RGG) domain of TLS (translocated in liposarcoma). Here we show that RGGF recognizes DNA loops in the G-quadruplex and preferentially binds G-quadruplex DNA with long loops. Furthermore, RGGF binds to G-quadruplex DNA of the c-myc promoter in vitro and represses c-myc transcription in vivo. On the basis of these findings, G-quadruplex binding protein engineered from the RGG domain will be useful for investigating G-quadruplex transcriptional function in the genome.
Businesses and COVID-19 impact, liquidity issues and failure perceptions: The case of Albania
Authors: Shosha Bitila , Mano Romeo , Anamali Armela
Published: April 2022

This paper aims to analyze business liquidity perceptions during the Covid-19 lockdown and how the lockdown affected businesses. The research methodology used in this paper consists of a literature review on businesses in the lockdown and an analysis of data collected through a survey conducted in the second quarter of 2020, immediately after the Covid-19 restriction measures were imposed. The sample used contains 180 businesses from a population of 166,386 businesses in Albania, providing a 7.30% error according to the Raosoft calculator. A more in-depth analysis was made by comparison, using box-plots for liquidity issues and problems faced by small, medium and large businesses (SMLEs) during the pandemic. The degree of significance of factors taken into consideration in this study is expressed by Pearson’s Correlation Coefficient (PCC) and an econometric model. The processing and analysis of data was made using SPSS V21. From the analysis of the factors considered and the size of the business, two important conclusions emerge: (1) the exercise of activity for Albanian businesses is closely related to the payments and the business perspective (bankruptcy risk); (2) the fear of bankruptcy was felt more by big business, while medium business had fewer problems referring to all the factors taken into consideration. The econometric model determined the most important factors for assessing the level of impact of Covid-19: Failure Perception, Support from Solidarity Packages, and Cash Reserves Usage. Surprisingly, it is noticed that businesses attribute the use of cash reserves (C.R.U) to different expenses/liabilities compared to the traditional ones treated in this study.
Displaced Venezuelans and the Politics of Asylum
Authors: Felipy Luiz
Published: April 2022

Latin America is often referred to as a particularly successful case in refugee protection where, through the 1984 Cartagena Declaration, States have established a tradition of openness, solidarity, and humanitarism. Nevertheless, in practice, the instrument has been unevenly implemented in the region. This has posed consequences to the protection of displaced Venezuelans, who are now the second largest displaced population in the world and often live with precarious statuses. Applying process tracing as a methodology, this paper analyses the case of Brazil, one of the few countries granting asylum to this population, and identifies the drivers which influenced its response.
VIVÊNCIAS DE UMA MESTRANDA EM TEMPOS DE PANDEMIA
Authors: Boniatti Juliana , Maria Fachinetto Juliana , Antonio Gonzalez da Silva José , De Fatima Colet Christiane , Miladi Fernandes Stumm Eniva
Published: April 2022

O ano de 2020 está marcado por uma epidemia intitulada Novo Coronavírus, a qual mudou drasticamente o comportamento da humanidade. A partir das medidas de isolamento social adotadas, ocorreram impactos no processo de ensino e aprendizagem em estudantes e seus respectivos familiares. Busca-se com o presente trabalho contextualizar acerca de vivências de uma mestranda durante a pandemia da COVID-19. Um misto de sentimentos é vivenciado pela autora, como mestranda, na tentativa de manter a normalidade e dar continuidade ao mestrado, mesmo diante da necessidade de replanejamento rápido e das incertezas e medos oriundos da pandemia. A Universidade se reinventou e oportunizou acesso a ferramentas que mesmo à distância promoveram conhecimento. Vivenciar a pandemia, apesar da gravidade da doença e das mudanças organizacionais advindas desse contexto doloroso, implica e requer enfrentamento e adaptação no convívio institucional, pessoal e coletivo. Na formação como seres humanos, considera-se que, a partir das dificuldades enfrentadas é que emergem verdadeiras oportunidades de transformação e de inovação.
PINTURA MURAL COMO ESTRATÉGIA PARA INTEGRAÇÃO DE ÁREAS DE CONHECIMENTO E REVITALIZAÇÃO DE ESPAÇOS ESCOLARES
Authors: Miranda Pinto Jaqueline , Nunes Sepel Lenira Maria
Published: April 2022

BioRevitArt é um projeto desenvolvido desde 2014 em uma escola pública estadual do município de São Gabriel/RS, tendo como objetivos incentivar a realização de atividades integradas entre as áreas de ensino, fortalecer o sentimento de pertencimento em relação à escola e valorizar experiências de cooperação. Em cinco anos de funcionamento o projeto BioRevitArt teve a participação de 337 alunos e foram produzidos 16 murais que abordaram temas variados. A realização do projeto é descrita em três etapas, a primeira tem caráter administrativo – pedagógico e define como as atividades serão integradas ao planejamento de ensino das disciplinas envolvidas. As etapas denominadas Pesquisa e Produção são realizadas pelos estudantes com mediação dos professores (coordenador do projeto e colaboradores). O encerramento do projeto é a entrega do mural para a escola, sendo um momento comemorativo em que os participantes assinam a obra e a dedicam aos alunos e professores que utilizarão a sala no futuro. As atividades desenvolvidas ao longo do projeto fazem parte do processo de avaliação das turmas e são analisadas sob o ponto de vista de desenvolvimento de componentes atitudinais e procedimentais associados ao desenvolvimento de trabalho em equipe.
PADRONIZAÇÃO DA COLETA DE INFORMAÇÕES PARA A PLATAFORMA SUCUPIRA PELOS PROGRAMAS DE PÓS-GRADUAÇÃO POR MEIO DA GESTÃO POR PROCESSOS
Authors: Carvalho Priscila Helen , Migliato Vanessa Cristina , Argoud Ana Rita Tiradentes Terra
Published: April 2022

Os programas de pós-graduação (PPG) no Brasil são submetidos à avaliação quadrienal pela Capes e devem enviar anualmente informações por meio da Plataforma Sucupira, que é um dos itens que compõe esta avaliação, Na Universidade Federal de São Carlos (UFSCar), apesar dos programas possuírem um regimento geral, cada um possui seu próprio regimento interno, resultando na falta de comunicação entre os programas em relação a execução de tarefas internas e, consequentemente, ausência de padronização dos processos e procedimentos. O presente estudo tem como objetivo apurar como é realizada a coleta dessas informações pelos PPGs da UFSCar para alimentação da Plataforma Sucupira e relatar as principais dificuldades enfrentadas. Para tanto se desenvolveu uma pesquisa qualitativa, por meio de método exploratório com as técnicas de pesquisas bibliográfica e pesquisa-ação. Como resultado, a pesquisa traz o mapeamento e análise do processo de coleta de dados para a Plataforma Sucupira. Dessa forma, apresenta uma contribuição a um processo crítico aos programas de pós graduação da universidade e do Brasil.
LABORATÓRIO DE QUÍMICA E METODOLOGIA ATIVA NO PROCESSO DE APRENDIZAGEM ESCOLAR
Authors: Caberlon Maggioni Maria Celeste , Caberlon Maggioni Israel , Finimundi Nóbile Márcia
Published: April 2022

O artigo tem como objetivo refletir o uso do laboratório de química na era da cultura digital, considerando-o uma metodologia ativa no processo de aprendizagem. Para isso, são relatadas fases do desenvolvimento humano conforme Piaget e Vygotsky, com a continuidade abordando o laboratório para os estudantes do Ensino Médio, considerando a faixa etária e a necessidade de conhecimentos mínimos sobre reagentes e equipamentos presentes neste espaço físico. A metodologia exploratória de cunho bibliográfica utilizada possibilitará a sequência deste estudo, utilizando às diretrizes do Ensino Médio a partir do ano de 1990, e a relação entre o laboratório de química e as metodologias ativas, tema em voga na educação. Os resultados apontam que a mobilização de conceitos e as discussões coletivas propiciadas na realização de um experimento, possibilitam aos estudantes atuarem como sujeitos ativos do processo, além de associarem a química a questões éticas e de responsabilidade social. Por fim, deve-se levar em conta o laboratório de química como uma metodologia ativa de aprendizagem para a formação de cidadãos éticos e comprometidos com o planeta.
Recent Advances in Acid-sensitive Ion Channels in Central Nervous System Diseases
Authors: Zhu Yueqin , Hu Xiaojie , Wang Lili , Zhang Jin , Pan Xuesheng , Li Yangyang , Cao Rui , Li Bowen , Lin Huimin , Wang Yanan , Zuo Longquan , Huang Yan
Published: April 2022

Acid-sensitive ion channels (ASICs) are cationic channels activated by extracellular protons and widely distributed in the nervous system of mammals. It belongs to the ENaC/DEG family and has four coding genes: ASIC1, ASIC2, ASIC3, and ASIC4, which encode eight subunit proteins: ASIC1a, ASIC1b, ASIC1b2, ASIC2a, ASIC2b, ASIC3, ASIC4, and ASIC5. Different subtypes of ASICs have different distributions in the central nervous system, and they play an important role in various physiological and pathological processes of the central nervous system, including synaptic plasticity, anxiety disorders, fear conditioning, depressionrelated behavior, epilepsy, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, multiple sclerosis, malignant Glioma, pain, and others. This paper reviewed the recent studies of ASICs on the central nervous system to improve the understanding of ASICs’ physiological functions and pathological effects. This article also references studying the molecular mechanisms and therapeutic measures of nervous system-related diseases.
The Advances and Challenges in Enzymatic C-glycosylation of Flavonoids in Plants
Authors: Gao Hui-Yao , Liu Yan , Tan Fei-Fan , Zhu Li-Wen , Jia Kai-Zhi , Tang Ya-Jie
Published: April 2022

Flavonoid glycosides play determinant roles in plants and have considerable potential for applications
in medicine and biotechnology. Glycosyltransferases transfer a sugar moiety from uridine diphosphateactivated
sugar molecules to an acceptor flavonoid via C-O and C-C linkages. Compared with O-glycosyl flavonoids,
C-glycosyl flavonoids are more stable, resistant to glycosidase or acid hydrolysis, exhibit better pharmacological
properties, and have received more attention. In this study, we discuss the mining of C-glycosyl
flavones and the corresponding C-glycosyltransferases and evaluate the differences in structure and catalytic
mechanisms between C-glycosyltransferase and O-glycosyltransferase. We conclude that promiscuity and specificity
are key determinants for general flavonoid C-glycosyltransferase engineering and summarize the
C-glycosyltransferase engineering strategy. A thorough understanding of the properties, catalytic mechanisms,
and engineering of C-glycosyltransferases will be critical for future biotechnological applications in areas such
as the production of desired C-glycosyl flavonoids for nutritional or medicinal use.
Flavonoids as Sirtuin Modulators
Authors: Deniz Fatma Sezer Şenol , Eren Gökçen , Orhan Ilkay Erdogan
Published: April 2022

Sirtuins (SIRTs) are described as NAD+-dependent deacetylases, also known as class III histone deacetylases. So far, seven sirtuin genes (SIRTS 1–7) have been identified and characterized in mammals and also known to occur in bacteria and eukaryotes. SIRTs are involved in various biological processes including endocrine system, apoptosis, aging and longevity, diabetes, rheumatoid arthritis, obesity, inflammation, etc. Among them, the best characterized one is SIRT1. Actually, small molecules seem to be the most effective SIRT modulators. Flavonoids have been reported to possess many positive effects favrable for human health, while a relatively less research has been reported so far on their funcions as SIRT modulation mechanisms. In this regard, we herein aimed to focus on modulatory effects of flavonoids on SIRTs as the most common secondary metabolites in natural products. Our literature survey covering the years of 2006-2021 pointed out that flavonoids frequently interact with SIRT1 and SIRT3 followed by SIRT6. It can be also concluded that some popular flavonoid derivatives, e.g. resveratrol, quercetin, and catechin derivatives came forward in terms of SIRT modulation.
MicroRNAs as a Novel Player for Differentiation of Mesenchymal Stem
Cells into Cardiomyocytes
Authors: Azizidoost Shirin , Farzaneh Maryam
Published: April 2022

Cardiovascular disease (CVD) is defined as a class of disorders affecting the heart and blood
vessels. Cardiomyocytes and endothelial cells play important roles in cardiac regeneration and heart repair.
However, the proliferating capacity of cardiomyocytes is limited. To overcome this issue, mesenchymal
stem cells (MSCs) have emerged as an alternative strategy for CVD therapy. MSCs can proliferate
and differentiate (or trans-differentiate) into cardiomyocytes. Several in vitro and in vivo differentiation
protocols have been used to obtain MSCs-derived cardiomyocytes. It was recently investigated that
microRNAs (miRNAs) by targeting several signaling pathways, including STAT3, Wnt/β-catenin, Notch,
and TBX5, play a crucial role in regulating cardiomyocytes' differentiation of MSCs. In this review, we
focused on the role of miRNAs in the differentiation of MSCs into cardiomyocytes.
The Emergence of Omicron SARS-CoV-2 Variant (B.1.1.529): The Latest
Episode in the COVID-19 Pandemic with a Global Riposte
Authors: Ray Suman Kumar , Mukherjee Sukhes
Published: April 2022

Over two years after the start of the SARS-CoV-2 epidemic, which has demised over 5 million
people, the world is still on high COVID-19 alert in February 2022, and new variants are emerging.
Since January 2020, the World Health Organization (WHO) has been closely monitoring and analyzing
the evolution of SARS-CoV-2 in partnership with national authorities, public health organizations,
and scientists. To prioritize global monitoring and research and to guide the continuing global
response to the COVID-19 pandemic, distinct SARS-CoV-2 variants were labelled as Variant of Interest
(VOI) and Variant of Concern (VOC). The World Health Organization and its international sequencing
networks are constantly monitoring SARS-CoV-2 mutations and informing countries about
any adjustments that may be required to respond to the variant and, where possible, prevent its spread.
Since January 2021, multiple viral variations have evolved and grown dominant in numerous countries,
with the Alpha, Beta, Gamma, and Delta varieties being the most prevalent too far. On November 20,
2021, Omicron was born into a COVID-19-weary world, replete with rage and resentment at the pandemic's
broad detrimental effects on social, emotional, and economic well-being. Although earlier
VOCs originated in a world where natural immunity to COVID-19 infections was widespread, the fifth
VOC, Omicron, has emerged in an environment where vaccine immunity is rising.
Natural Products as Bioactive Agents in the Prevention of Dementia
Authors: Rasool Mahmood , Ullah Hamid , Hussain Abrar , Asif Muhammad , Nawaz Faheem
Published: April 2022

Dementia is a complex syndrome of neurological disorders which is associated with cognitive
functions of the body. The present review focuses on the role and application of natural products
in the treatment of dementia and related diseases. The studies highlight that there exist some potent
synthetic/semisynthetic drugs that can effectively target dementia and related diseases. In contrast, despite
the existence of a large library of natural products, only a few of them (galantamine, huperzine
A, etc.) have been approved as drugs against dementia. This fact is not discouraging because a large
number of natural products, including classes of polyphenols, alkaloids, isothiocyanates, phytocannabinoids,
and terpenoids, are in the process of drug development stages against dementia and related
diseases. It is because they display some promising and diverse biological activities, including antioxidant,
acetylcholinesterase inhibitory activity, and anti-amyloidogenic properties, which are significantly
associated with the prevention of dementia syndrome. The studies reported in the literature reveal
that bioactive natural products particularly target Alzheimer’s and Parkinson’s diseases by suppressing
the risks responsible for dementia. Huperzine A has been identified as a potent natural product
against Alzheimer’s disease. Despite the efficient role of natural products in preventing dementia,
their direct application as drugs is still limited due to some controversial results obtained from their
clinical trials; however, bioassay-guided drug development studies can prove them potential drugs
against dementia and related diseases. This review provides useful information for researchers, pharmacologists,
and medical doctors.
Marine Biomaterials for Pharmaceutical Applications: A Review
Authors: Murti Yogesh , Semwal Bhupesh Chander , Singh Sonia
Published: April 2022

Background:

Marine ecosystem is one of the main natural sources of numerous biologically active components along with rich biodiversity. Marine biomaterials obtained from fungi, algae, bacteria, and fish, are considered promising candidates for providing various biological as well as biomedical application(s).

Objective:

The main focused objective of this manuscript is to take out the recent trends utilized in several marine-based biomaterials developed for pharmaceutical applications.

Method:

The literature contains valuable and collective information on the different bioactivities of marine-based biomaterials. A total of 287 articles are cited in the present review covering a broad spectrum of marine biomaterials, and their pharmaceutical importance. Information of different marine biomaterials along with their source, chemical nature, and pharmaceutical importance are exhaustively compiled here.

Results:

Marine-based biomaterials possess a wide range of physiochemical activities and modifications in these properties can also enhance the therapeutic and regenerative capacity. Marine biomaterials have proven a good source for the development of different areas of the pharmaceutical field and still, the application of marine biomaterials is going through revitalization in the biomedical field.

Conclusion:

Due to the amazing diversity involved in marine life, there would be more significant and remarked discoveries developed in the field of marine biomaterials in respect of future implementation in the pharmaceutical arena.
Efecto de los parámetros cinéticos de escalamiento del cultivo de Haematococcus pluvialis en fotobiorreactores para producir astaxantina
Authors: Martinez Rodriguez Paula Andrea , Peinado Cardenas Maria Jose , Camacho Kurmen Judith Elena
Published: April 2022

El Haematococcus pluvialis es una microalga de interés biotecnológico por su capacidad para producir astaxantina, un carotenoide que tiene uso como pigmento y compuesto bioactivo, con aplicación en la industria farmacéutica, cosmética, nutracéutica, alimenticia y la acuacultura. Este carotenoide se obtiene cuando la microalga es sometida a condiciones de estrés como intensidad de luz, color de luz, deficiencia de nutrientes y salinidad, e involucra el uso de fotobiorreactores (fbr). Por esto, este artículo busca conocer el tipo de fbr que se ha utilizado en su escalamiento y los parámetros cinéticos relacionados que influyen en el rendimiento del proceso. Los fbr facilitan el ajuste y control de las condiciones de cultivo, tanto en la fase verde como en la fase roja; de igual manera, el uso de los parámetros cinéticos de escalamiento permiten evaluar el proceso y así establecer las condiciones que deben ajustarse, para mejorar el cultivo de la microalga y la obtención de astaxantina. Los parámetros cinéticos de escalamiento revisados fueron la biomasa (cel./mL), la productividad de biomasa (g/Ldía), la velocidad específica de crecimiento (µ/día), el tiempo de duplicación (día), el contenido de astaxantina (mg/g) y su productividad. Se demuestra así la factibilidad tecnológica de los fotobiorreactores para el escalamiento de la microalga para producir astaxantina. Los fbr más usados son los de forma tubular y cilíndrica por tener una superficie mayor de iluminación y eficiencia en la distribución de la luz, y por reportar mayor productividad de astaxantina; su desventaja pueden ser los costos de limpieza.
Manual de reconocimiento y cría de Dynamis borassi (Coleoptera: Dryophthoridae), una plaga de las palmas en América Latina
Authors: Cuellar Palacios Claudia Marcela , Gaviria Vega Jackeline , Montoya Lerma James
Published: April 2022

La presente publicación recopila los resultados de investigación desarrollados en la Corporación Colombiana de Investigación Agropecuaria (AGROSAVIA), Palmira, Valle, y en la Universidad del Valle, Cali, Colombia. Está dirigida principalmente a investigadores, con el objetivo de aportar al conocimiento de la biología de Dynamis borassi, así como proporcionar un manual que ayude a la identificación de esta especie, a su diferenciación morfológica y a la producción continua de los diferentes estadios de la especie para el desarrollo de investigaciones en laboratorio. La información presentada en este documento es el resultado de las observaciones y experimentos realizados por más de dos años.
Effectiveness of Web-Based Personalized Nutrition Advice for Adults Using the eNutri Web App: Evidence From the EatWellUK Randomized Controlled Trial
Authors: Zenun Franco Rodrigo , Fallaize Rosalind , Weech Michelle , Hwang Faustina , Lovegrove Julie A
Published: April 2022

Background

Evidence suggests that eating behaviors and adherence to dietary guidelines can be improved using nutrition-related apps. Apps delivering personalized nutrition (PN) advice to users can provide individual support at scale with relatively low cost.

Objective

This study aims to investigate the effectiveness of a mobile web app (eNutri) that delivers automated PN advice for improving diet quality, relative to general population food-based dietary guidelines.

Methods

Nondiseased UK adults (aged >18 years) were randomized to PN advice or control advice (population-based healthy eating guidelines) in a 12-week controlled, parallel, single-blinded dietary intervention, which was delivered on the web. Dietary intake was assessed using the eNutri Food Frequency Questionnaire (FFQ). An 11-item US modified Alternative Healthy Eating Index (m-AHEI), which aligned with UK dietary and nutritional recommendations, was used to derive the automated PN advice. The primary outcome was a change in diet quality (m-AHEI) at 12 weeks. Participant surveys evaluated the PN report (week 12) and longer-term impact of the PN advice (mean 5.9, SD 0.65 months, after completion of the study).

Results

Following the baseline FFQ, 210 participants completed at least 1 additional FFQ, and 23 outliers were excluded for unfeasible dietary intakes. The mean interval between FFQs was 10.8 weeks. A total of 96 participants were included in the PN group (mean age 43.5, SD 15.9 years; mean BMI 24.8, SD 4.4 kg/m2) and 91 in the control group (mean age 42.8, SD 14.0 years; mean BMI 24.2, SD 4.4 kg/m2). Compared with that in the control group, the overall m-AHEI score increased by 3.5 out of 100 (95% CI 1.19-5.78) in the PN group, which was equivalent to an increase of 6.1% (P=.003). Specifically, the m-AHEI components nuts and legumes and red and processed meat showed significant improvements in the PN group (P=.04). At follow-up, 64% (27/42) of PN participants agreed that, compared with baseline, they were still following some (any) of the advice received and 31% (13/42) were still motivated to improve their diet.

Conclusions

These findings suggest that the eNutri app is an effective web-based tool for the automated delivery of PN advice. Furthermore, eNutri was demonstrated to improve short-term diet quality and increase engagement in healthy eating behaviors in UK adults, as compared with population-based healthy eating guidelines. This work represents an important landmark in the field of automatically delivered web-based personalized dietary interventions.

Trial Registration

ClinicalTrials.gov NCT03250858; https://clinicaltrials.gov/ct2/show/NCT03250858
Design of a Clinical Balance Tool for Falls Risk Assessment: Development and Usability Study (Preprint)
Authors: Garvin Jennifer Hornung , Yazzie Virginia Margaret , Worthen-Chaudhari Lise C. , Chaudhari Ajit M. W.
Published: April 2022

BACKGROUND

Falls are a significant source of early morbidity and mortality in the aging population, yet the neurological, sensory, and motor changes that lead to increased falls risk often escape early identification and intervention. Measurement of postural control in the clinical setting could facilitate evidence-based falls risk assessment.

OBJECTIVE

The two main objectives were to develop a prototype quantitative postural control measurement tool (qPCM) for measurement to replace a weight scale and to understand barriers and facilitators to assessing falls risk that could be addressed by qPCM.

METHODS

An observational study in the practice setting was conducted with two rounds of semi-structured interviews over seven months to evaluate critical functionality and workflow requirements to inform the design of the qPCM. Physicians (8), Medical Assistants or Physician Extenders (8), and Nurse Practitioners (2) were recruited from physician- and nurse-practitioner-run outpatient clinics in primary care, medical oncology, sports medicine, cardiology, and endocrinology. We gathered initial information to identify requirements and assess workflow to iteratively develop the qPCM with two rounds of interviews with clinical scenarios and the System Usability Scale (SUS). We assessed barriers and facilitators of assessing falls risk and of using qPCM and modified the qPCM after each round.

RESULTS

Eighteen clinicians participated in both rounds of formative evaluation. Some physical attributes of the device and patient characteristics created barriers as well as facilitators for use of the device. Participants reported willingness to use the device with all patients during the first round of interviews and reported they would replace their current weight scale with the modified device during the second round of interviews. SUS scores were 83.6/100 after the first round and 86.8/100 after the second round. Several barriers to an evidence-based assessment of falls risk were identified including lack of knowledge regarding national guidelines and lack of consistent training.

CONCLUSIONS

The quantitative postural control measurement tool device provides a new method for quantifying falls risk with good user acceptance and usability and feasibility in a clinic environment without disrupting the workflow. The qPCM measurements supplemented and facilitated use of standard algorithms for falls risk assessment. Providers described qPCM as useful to more definitively identify people at risk of falls. Greater education of the entire care team regarding evidence-based falls risk assessments could promote adherence and fall prevention.

CLINICALTRIAL

clinicaltrials.gov/ct2/show/NCT04139642
Cyberspace dalam novel “The Messenger”
Authors: Istiarni Atin
Published: April 2022

Perkembangan industri mulai dari era 1.0 hingga menjelang 5.0 selalu ditandai dengan kemajuan yang terjadi pada dunia teknologi informasi hingga mempengaruhi aspek kehidupan manusia secara global. Perkembangan tersebut kemudian memaksa manusia untuk bersinggungan dengan dua realitas dunia yaitu maya dan konkrit. Problematika yang timbul sebagai gambaran bagi manusia yang memiliki interaksi di dua dunia yakni dunia realitas konkrit dan realitas tampakan tergambar dalam novel “The Messenger” yang ditulis oleh Labibah Zain, dkk. Penelitian ini adalah penelitian yang berpijak pada ilmu filsafat sebagai landasan berfikir. Dalam penelitian ini, digunakan perspektif kritik humanis Mark Slouka sebagai pisau analisa. Dengan menggunakan perspektif kritik humanis yang dicetuskan oleh Mark Slouka, peneliti ingin memaparkan realitas semu (hyperrealitas) akibat adanya ruang cyber yang tergambar dalam novel “The Messenger”. Namun, pisau analisis yang digunakan tak sepenuhnya absolut, akan tetapi lebih kepada hasil reflektif dari peneliti. Penelitian ini termasuk dalam studi pustaka dengan objek kajiannya adalah alur cerita dan setting dalam novel “The Messenger”. Hasil penelitian dipaparkan menggunakan metode deskriptif. Adapun hasil penelitian menggolongkan novel ini termasuk dalam golongan Teknorealis. Hal tersebut direpresentasikan dalam konsep realitas, identitas, komunitas, dan ruang yang tergambar dalam novel
Implementasi program anti plagiarisme sebagai upaya meningkatkan kualitas karya ilmiah Mahasiswa di Perpustakaan UGM Kampus Jakarta
Authors: Wijayanti Nova Indah
Published: April 2022

Penyebab plagiarisme adalah faktor internal (dalam diri) dan faktor eksternal. Tindakan plagirisme ini merupakan perbuatan yang tidak etis, bisa terjadi karena pengaruh faktor lingkungan sekitar. Lingkungan sosial memiliki pengaruh yang besar terhadap perilaku tidak jujur yaitu berupa harapan sosial bahwa seseorang yang dianggap pandai adalah yang memiliki nilai tinggi, mendapat penghargaan dan penerimaan di lingkungan social Kejujuran dan orisinalitas karya ilmilah termasuk etika moral termasuk dalam dalam ranah character building atau pembentukan karakter. Character building adalah suatu upaya untuk membangun dan membentuk akhlak budi pekerti seseorang menjadi baikTren kasus plagiarisme yang terjadi di Indonesia berbeda dengan kasus yang terjadi di luar negeri. Di Indonesia sudah mencapai level yang lebih tinggi yaitu kalangan pendidik seperti dosen bahkan pimpinan Universitas. Kegiatan ini diperlukan sebagai upaya pustakawan mendukung peningkatan kualitas karya ilmiah di Perguruan tinggi. Peran pustakawan tidak lagi hanya melayani informasi kepada pemustaka tetapi memiliki tugas memberikan pengetahuan tentang antiplagiarisme. Perpustakaan UGM Kampus Jakarta sejak tahun 2015 telah dilakukan kegiatan Literasi informasi untuk mahasiswa. Kegiatan tersebut menjadi bagian dari peran pustakawan dalam mendukung anti plagiarisme. Tindakan pencegahan plagiarism menjadi efektif apabila seluruh pihak berkolaborasi mendukung pelakasanaan.
Pustakawan Mandiri dalam Pengelolaan Perpustakaan Khusus Departemen Ilmu Kebidanan dan Kandungan Fakultas Kedokteran Kesehatan Masyarakat dan Keperawatan Universitas Gadjah Mada
Authors: Mustar Maniso , Albar Achmad Syukur
Published: April 2022

Departemen Ilmu Kebidanan dan Kandungan Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan (FK-KMK) adalah bagian dari program pendidikan perguruan tinggi yang menjalankan proses belajar-mengajar yang berbasis Evidance Based Medicine (EBM). Untuk menunjang program tersebut, departemen memberikan berbagai solusi, salah satunya adalah program pelayanan perpustakaan ilmu kesehatan khususnya ilmu kebidanan dan kandungan. Untuk mendapatkan hasil yang optimal, maka pustakawan melakukan studi literasi dari berbagai sumber dengan tujuan dapat terselenggara proses layanan perpustakaan yang efektif sesuai bidang keilmuan. Program tersebut dintaranya integrasi perpustakaan, digitalisasi karya ilmiah, pemetaan sumber informasi dan melaksanakan difusi informasi secara cepat dan tepat. Dengan program tersebut diharapkan terbentuk peran penting dalam proses pengelolaan perpustakaan, yang mampu memenuhi kebutuhan pemustaka untuk mengikuti perkembangan teknologi yang semakin pesat dan dapat tercipta pustakawan yang terampil, cakap, dan inovatif dalam menghadirkan layanan-layanan yang memudahkan dalam proses temu kembali informasi secara cepat, tepat dan akurat.
Kode etik profesi: Asta etika Pustakawan Indonesia
Authors: Sarwono
Published: April 2022

Norma atau etika diperlukan dalam kehidupan sehari-hari. Tanpa adanya etika maka hubungan antar manusia tidak akan berjalan dengan baik. Demikian pula dalam kehidupan profesi seseorang diperlukan adanya pedoman dalam bertindak dan berbuat agar sesuai dengan tuntutan profesinya. Profesi pustakawan memiliki etika yang disebut dengan kode etik pustakawan. Kode etik ini disusun oleh Ikatan Pustakawan Indonesia (IPI) sebagai organisasi profesi pustakawan di Indonesia. Dalam setiap kongresnya, kode etik pustakawan senantiasa dibahas. Pada kongres tahun 2018 kode etik pustakawan diganti namanya menjadi Asta Etika Pustakawan Indonesia, yaitu: melaksanakan tugas sesuai dengan harapan pemustaka, meningkatkan kompetensi setinggi-tingginya, membedakan antara pandangan pribadi dan tugas profesi, menjamin tindakan dan keputusannya berdasarkan profesionalisme, menjunjung tinggi hak informasi perseorangan dan menyediakan akses tak terbatas, melindungi hak privasi pemustaka dan tidak bertanggungjawab atas penggunaan informasi, mengakui dan menghormati hak kekayaan intelektual, dan menjalin kerjasama dan menghargai teman sejawat.
Variasi topik penelitian Pustakawan untuk menunjang reputasi Universitas pada level internasional
Authors: Adi Nugroho Prasetyo
Published: April 2022

Perpustakaan merupakan markas untuk mencari ilmu pengetahuan yang berguna untuk meningkatkan literasi masyarakat. Pustakawan perlu berkolaborasi dengan akademisi untuk memulai budaya riset. Studi ini bertujuan untuk menganalisis apakah ada korelasi antara peringkat perguruan tinggi berdasarkan Webometric dengan variasi penelitian tentang perpustakaan pada paper berstandar internasional. Studi ini menggunakan data sekunder dengan teknik data mining. Sampel studi ini yaitu karya ilmiah yang tercantum pada halaman web scopus. Sampel berasal dari UI, ITB, dan Universitas Brawijaya. Hasil penelitian menunjukkan bahwa semakin tinggi ranking universitas, semakin banyak pula varian subtopik papernya. Selain itu, studi tentang kepustakaan selalu berkaitan dengan teknologi informas dan big data.
Mengenal G. KOLFF, BOEKHANDEL TAN KHOEN SWIE dan BALAI PUSTAKA: Penerbit Buku Langka Masa Politik Etis Awal Abad 20
Authors: Maryono
Published: April 2022

Artikel ini berfokus pada penerbit buku langka Indonesiana, khususnya yang diterbitkan pada masa politik etis awal abad 20. Penerbitan pada masa tersebut, cukup menarik untuk dikaji karena pada masa tersebut muncul kebijakan baru “politik etis” oleh pemerintah kolonial Belanda untuk memperbaiki kesejahteraan masyarakat di Indonesia, terutama di bidang pendidikan. Pada masa tersebut terdapat beberapa Penerbit yang cukup menonjol diantaranya Bale Poestaka, Boekhandel Tan Khoen Swie, dan G. Kolff. Ketiganya memiliki karakteristik dan idealisme masing-masing. Kajian ini akan membatasi studi pustaka pada ketiga penerbit besar tersebut, bukan saja karena penerbit-penerbit tersebut berperan penting dalam mencerahkan kehidupan bangsa, tetapi juga karena banyaknya koleksi langka Indonesiana di Perpustakaan UGM yang berasal dari ketiga penerbit besar tersebut.
Peran Pustakawan Universitas Gadjah Mada sebagai mitra riset di masa pandemi Covid-19
Authors: Isbandini
Published: April 2022

Di masa pandemi COVID-19 ini, kegiatan belajar mengajar dan penelitian di perguruan tinggi tetap berjalan dengan sistem online dengan memanfaatkan jaringan internet. Mahasiswa UGM juga dituntut untuk tetap menyelesaikan studi dan tugas akhirnya tepat waktu meskipun harus berkonsultasi dengan dosen pembimbing secara online. Mahasiswa juga membutuhkan informasi dan literatur agar tugas akhir dapat segera diselesaikan. Hal ini berdampak pada perpustakaan perguruan tinggi, termasuk perpustakaan UGM yang tidak membuka layanan tatap muka selama tanggap darurat COVID-19 ini. Dengan ditutupnya layanan secara tatap muka, pemustaka tidak bisa akses informasi secara langsung ke perpustakaan, sedangkan kegiatan belajar dan riset tetap berjalan, sehingga diperlukan inovasi agar layanan tetap berjalan meskipun pemustaka tidak bisa berkunjung ke perpustakaan UGM. Inovasi yang dilakukan Perpustakaan UGM yaitu dengan membuka layanan online. Pemustaka bisa mendapatkan informasi yang dibutuhkan secara online melalui email. Pustakawan memainkan peranan yang sangat penting dalam layanan online ini dengan menyediakan sumber-sumber informasi untuk mendukung kegiatan penelitian/riset. Berdasarkan data yang masuk melalui form bantuan layanan dari tanggal 19 Maret s/d 31 Juli 2020 , pengguna yang memanfaatkan layanan online ini sebanyak 3.863. Pemustaka dengan jenis pemustaka terbanyak yaitu dari mahasiswa UGM 3.638 atau 94,18%. Pengguna layanan online berdasarkan asal fakultas paling tinggi dari fakultas teknik yaitu sebesar 569 orang atau 15,64%, pengguna layanan online berdasar kebutuhan akses paling tinggi adalah akses koleksi ETD yaitu sebesar 3.201 atau 82,86%, layanan cek turnitin paling banyak adalah tugas akhir sebesar 184 atau 61,74%.
International impact metric of Mathematics: determining leadership through scientific impact
Authors: Sánchez-Perdomo Rubén , Herrera-Vallejera Darlenis , Gorbea-Portal Salvador , Carrillo-Calvet Humberto
Published: April 2022

El propósito de este estudio es determinar los perfiles de impacto científico de los países, instituciones y autores más destacados en el campo de las matemáticas a nivel internacional. Los datos se colectaron a partir de la herramienta Essential Science Indicators. Se utilizó el software LabSOM para determinar el perfil bibliométrico de los países, las instituciones y los autores más destacados sobre la base de un análisis multiparamétrico. Los resultados muestran que no coinciden los líderes de cada indicador bibliométrico en ninguno de los niveles de agregación analizados y demuestran que esos indicadores no deben aplicarse de manera uniforme en todos los campos para medir el desarrollo científico de las disciplinas, porque cada una muestra tasas de crecimiento distintas. La evaluación multiparamétrica permite la determinación simultánea de varios indicadores bibliométricos. Este método constituye una herramienta novedosa para el análisis multiparamétrico computacional y permite la aplicación de minería de datos bibliométricos a la toma de decisiones en el más alto nivel de la organización. La novedad del estudio radica no sólo en su alcance internacional y en la actualidad de sus datos, sino también en el uso de nuevos indicadores de impacto científico en la Matemática.
Evaluation of Colistin Broth Disk Elution and Colistin Agar Test: A study from Tertiary Care Hospital, South India
Authors: Sujatha S.R. , Deepashree R. , Tejashree A. , Sai Sathya
Published: April 2022

Enterobacterales particularly which are resistant to carbapenem group of antibiotics (CRE) are precariously being reported worldwide. Last option for treating the infections caused by CRE are polymyxin E (Colistin) and polymyxin B. Resistance to polymyxins is on higher side because of its increased usage both clinically and non-clinically. In vitro evaluation tests for susceptibility of colistin is associated with lot of complexities due to its innate cationic properties. Hence it is essential for all diagnostic laboratory to standardize colistin testing method, so the present study was undertaken to evaluate the results of colistin broth disk elution (CBDE) and colistin agar test (CAT) in comparison with the reference broth microdilution (rBMD). About 100 CRE clinical isolates were tested, results of CBDE & CAT was compared with rBMD. Categorical agreement (CA) of CBDE was 98% with 2% of very major error (VME), CA of CAT was 99% with 1% of VME in comparison with rBMD. Because of increasing colistin resistance it is crucial to report colistin MIC with a validated method, so we would like to recommend CAT test for routine MIC reporting of colistin since it is feasible test.
Molecular Study Of Hydatid Disease In Iraqi Goats By using The Mitochondrial Cytochrome C Oxidase Subunit 1 Gene
Authors: Muhaidi Mohammed J.
Published: April 2022

The aim of the present study was to identify and recognize the genotype for cystic Echinococcosis that infects goats (n=19) in Iraq. The hydatid cyst was collected from different parts of the body, i.e. lungs, liver, heart, spleen and peritoneal cavity. The current study was conducted in five different regions of Iraq (Anbar, Baghdad, Saladdin, Karkuk, Babylon during October 2018 to July 2019. The mitochondria DNA was extracted and screened for the presence of (CO1) cytochrome C oxidase subunit 1 gene using polymer chain reactions (PCR). Amplification size was around 450bp. The amplicon was isolated and purified. The isolated CO1 amplicon was sequenced. The CO1 putative sequence was BLAST with available sequence from NCBI. The genetic tree was deduced. The genotype G1 is the most frequently spread strains and considered as a key source for infection in goats of Iraq.
Acute Respiratory Distress Syndrome due to COVID-19 in India and efficacy of Indian Siddha drugs - A Trial of Lopinavir-Ritonavir
Authors: Rajeshbabu P. , Priadharsini K. , Riyaz S.U. Mohammed , Dhayalan Manikandan
Published: April 2022

Novel coronavirus pneumonia (COVID-19) is a respiratory infection caused by infecting lungs and respiratory pathways which has rapidly spread to 216 countries. It is causing serious harm to the world’s entire population and a huge social burden, which can spread mainly by droplets produced during coughing and sneezing from animal to animal or human to human. There were no drugs or vaccines available as of May 2020. Though the severity and infectious behavior and mortality rate of COVID-19 led to the discovery of various vaccines and drugs that are available to control COVID-19 pandemic. India has two vaccines: Covishield and Covaxin approved by the Government of India on 2nd January 2021. Of this sudden and lethal disease, the traditional Indian siddha medicine was proficient as an alternative source, in performing differentiation with fewer side effects and better ability to prevent and control. In this article, we have comprehensively analyzed the case study and the efficacy of Indian Siddha medicine Kabasura Kudineer chooranam. Naturally occurring Indian Siddha medicinal (Kabasura Kudineer chooranam) compounds and its treatment as prevention measures so as to provide strategy and suggestions for the disease COVID-19 are discussed.
Data Transmission in Wearable Sensor Network for Human Activity Monitoring Using Embedded Classifier Technique
Authors: Kumble Lithin , Patil Kiran Kumari
Published: April 2022

Abstract: The recent development of wireless wearable sensor networks has opened up a slew of new possibilities in industries as diverse as healthcare, medicine, activity monitoring, sports, safety, human-machine interface, and more. The battery-powered sensor nodes' longevity is critical to the technology's success. This research proposes a new strategy for increasing the lifetime of wearable sensor networks by eliminating redundant data transmissions. The proposed solution is based on embedded classifiers that allow sensor nodes to determine whether current sensor readings should be sent to the cluster head. A strategy was developed to train the classifiers, which takes into account the impact of data selection on the accuracy of a recognition system. This method was used to create a wearable sensor network prototype for human monitoring of activity Experiments were carried out in the real world to assess the novel method in terms of network lifetime, energy usage, and human activity recognition accuracy. The proposed strategy allows for a large increase in network lifetime while maintaining excellent activity detection accuracy, according to the results of the experimental evaluation. Experiments have also demonstrated that the technology has advantages over state-of-the-art data transmission reduction strategies. Keywords: wireless sensor network; wearable sensors; activity recognition; lifetime; energy con- sumption; transmission suppression; embedded machine learning
Psychological Analysis Using Social Media Data
Authors: Gawade Shriya , Sawant Riya , Rathod Aakash , Dhavale Prof. Chhaya
Published: April 2022

Abstract: Mental Stress is an important aspect of our life that is given the least importance. We tend to ignore the fact that we need to be emotionally stable along with physical stability. To keep your mental state sound, we proposed this system where the psychological state of a person is being predicted. One such place where a person comes up and shares his/her thoughts, through texts is on social media with their friends. To detect such a state, we made use of NLP techniques accompanied by a reliable scale, the Perceived Stress Scale (PSS) developed by Cohen, Kamarck and Mermelstein. The huge texts were cleaned using text processing methods. In Machine Learning, there are many ways for sentimental analysis such: decision-based systems, Bayesian classifiers, support vector machines, neural networks and sample-based methods. We have performed sentimental analysis and in order to give the severity of the condition we made use of the Perceived Stress Scale (PSS). The model will be predicting whether the given text indicates stress or not and further classifies it as low, medium or high-level stress. Keywords: TF-IDF, Natural Language Processing (NLP), Stress, WordCloud, Perceived Stress Scale
Common Ailments Possibility Using Machine Learning
Authors: Sameer Mohammed , . Omjee , Gupta Raghav , Tyagi Ritik , Mishra Annu
Published: April 2022

Abstract: Machine learning in healthcare helps humans to process large and complex medical datasets and then analyze them into clinical insights which can help physicians in providing better medical care. Therefore, machine learning, when implemented in the medical field can lead to increased patient satisfaction. In this research, we will try to implement the functionalities of machine learning in healthcare in a single system. Health care can be made smart with the help of machine learning. Many cases can occur when the early diagnosis of an ailment is not within reach, So, their ailment prediction cannot be effectively implemented. As widely said “Prevention is better than cure”, prediction of diseases would lead to early prevention of occurrence of disease. Medical Staff are often overworked in the medical field and hence the diagnosis becomes prone to human errors and negligence. Patients should be given treatment and diagnosis that are accurate and precise. Mistreatment may result in worsening the condition of the patient and hence the need for precise diagnosis. Therefore, the application of machine learning in disease prediction is considered in this paper as the best practice to facilitate a better healthcare system and provide better treatment to a patient as soon as possible. This paper majorly focuses on the development of a web app that would work on symptoms collected from the user and medical data and store it in the system. This data then will be analyzed using different machine learning algorithms to deliver results with maximum accuracy. Keywords: Machine Learning, Random forest, Support Vector Machine, Supervised learning.