bluuebunny/crossref_metadata_2025 huggingface dataset:
The distributed nature of pattern generalization

Authors: Rivera Ferdinand
Published: December 2021

Drawing on a review of recent work conducted in the area of pattern generalization (PG), this paper makes a case for a distributed view of PG, which basically situates processing ability in terms of convergences among several different factors that influence PG. Consequently, the distributed nature leads to different types of PG that depend on the nature of a given PG task and a host of cognitive, sociocultural, classroom-related, and unexplored factors. Individual learners draw on a complex net of parallel choices, where every choice depends on the strength of ongoing training and connections among factors, with some factors appearing to be more predictable than others.La naturaleza distribuida de la generalización de patronesSobre la base de una revisión de trabajos recientes en el área de generalización de patrones (PG), este artículo aboga por una visión distribuida de PG, que básicamente sitúa la capacidad de procesamiento en términos de convergencias entre diferentes factores que influyen en PG. En consecuencia, la naturaleza distribuida conduce a diferentes tipos de PG que dependen de la naturaleza de una tarea PG dada y una serie de factores cognitivos, socioculturales, inexplorados y relacionadas con el aula. Alumnos individuales se basan en una compleja red de opciones paralelas, donde cada elección depende de la fortaleza de la formación continua y las conexiones entre los factores, con algunos factores más predecibles que otros.Handle: http://hdl.handle.net/10481/34989WOS-ESCINº de citas en WOS (2017): 1 (Citas de 2º orden, 1)
Errores en la traducción de enunciados algebraicos entre los sistemas de representación simbólico y verbal

Authors: Rodríguez-Domingo Susana , Molina Marta , Cañadas María C. , Castro Encarnación
Published: December 2021

Este artículo describe parte de una investigación sobre las traducciones de expresiones algebraicas, entre los sistemas de representación simbólico y verbal, que realizan escolares de educación secundaria. El objetivo principal abordado es identificar y clasificar los errores en los que incurren los estudiantes al realizar dichas traducciones. Entre los resultados obtenidos destacamos la influencia de las características del simbolismo algebraico en los errores cometidos en la traducción de expresiones verbales a simbólicas y la mayor facilidad para traducir enunciados del sistema de representación simbólico al verbal.Errors in the Translation of Algebraic Statements between Symbolic and Verbal Representation SystemsThis article describes part of a study on secondary students’ translations between the symbolic and the verbal representation systems. The main objective is to identify and classify the errors they made when performing these translations. Among the obtained results we highlight the influence of the characteristics of algebraic symbolism in the errors made when translating from verbal to symbolic expressions and the larger ease to translate statements from the symbolic to the verbal representation system.Handle: http://hdl.handle.net/10481/36051WOS-ESCINº de citas en WOS (2017): 1 (Citas de 2º orden, 0)
Modern Methods of Treatment for Proximal Ureterolithiasis
Authors: Ozhogin Vladyslav
Published: December 2021

Urolithiasis is a disease characterized by the formation of stones in the urinary tract. According to statistics, SCC causes about 30% of hospitalizations in the urology department.
Treatment of SCC is divided into conservative and operative. The choice of method depends on age, clinical course of the disease, general condition of the patient, anatomical and functional condition of the kidneys and the size of the localization of the calculus. Methods of treatment of SC have changed significantly in recent years.
Due to the technical achievements of the method of open ureterolithotomy, which was once the standard method of treatment of so-called «complicated» concretions of the ureter, evolved into a laparoscopic ureterolithotomy, and with the advent of ultrasonic and laser lithotriptors – began the newest era of minimally invasive urology– extracorporeal shock-wave lithotripsy and endourology: antegrade percutaneous ureterolithotripsy, retrograde ureteroscopic lithotripsy and flexible retrograde uretherolithotripsy (FURS).
The purpose of the work – on the basis of scientific literature to assess the effectiveness, safety and profitability of modern methods of surgical treatment for proximal ureterolithiasis. During the scientific research, attention was paid to the following parameters: stone free rate (SFR), postoperative pain level, need for painkillers, number of postoperative bed-days, presence of postoperative fever, hemoglobin level, need for blood transfusion, and on the economic component during the implementation of a technique.
The principles of treatment of patients with large proximal ureterolithiasis are described in the clinical guidelines of the European and American Associations of Urologists. However, for example, which of the 3 proposed methods of treatment of large proximal ureterolithiasis to choose – there is no consensus from the world urological community.
Percutaneous antegrade ureterolithotripsy is the preferred method of choice in patients with large proximal ureteral stones that cannot be removed by contact or extracorporeal ureterolithotripsy, characterized by a high level of absence of stones and minimal complications, optimal post operative and high indicators of economic attractiveness of this technique.
Efek tepung ulat sagu (Rhynchophorus ferrugineus) terhadap penurunan kadar malondialdehyde (MDA) pada tikus Wistar dengan diet rendah protein
Authors: Lestari Lara Ayu , Sulchan M. , Legowo Anang M , Tjahjono Kusmiyati , Juniarto Achmad Zulfa
Published: December 2021

Kwashiorkor is protein-energy malnutrition (PEM) caused by protein deficiency. Sago worm flour (Rhynchophorus ferrugineus) can reduce malondialdehyde (MDA) caused by the high content of the amino acids glycine, lysine, and phenylalanine. The study aimed to prove the effect of sago worm flour on MDA levels in Wistar rats with a low protein diet. A true experimental-pre-post control group. The intervention was given for 28 days to 28 Wistar rats, divided into four groups with each group of seven rats. The dose of sago starch was 0,36 g/100 g rat body weight/day (P1), and a dose of 1,36 g/100 g rat body weight/day (P2) for rats fed a low diet protein. The treatment group was compared with a group of mice given a low diet protein (K +) and a group of healthy mice (K-). Serum MDA levels were measured by the TBARs method. Statistical analysis used paired t-test or Wilcoxon test and one-way ANOVA/Kruskal Wallis test. The results of decreasing MDA levels were in the P1 and P2 groups (p= 0,000). There was a difference in MDA levels in the P1 and P2 groups compared to the K + group (P= 0,000). There was a difference that decreased MDA levels between P1 and P2 (p= 0,000). In conclusion, sago worm flour at a dose of 0,36 g/100 g of rats/day and a dose of 1,36 g/100 g of body weight of rats/day can reduce MDA levels
Hubungan aktivitas fisik dan obesitas sentral dengan hiperglikemia wanita dewasa: Cross-sectional study
Authors: Bohari Bohari , Nuryani Nuryani , Abdullah Rukman , Amaliah Lili , Hafid Fahmi
Published: December 2021

Women in Indonesia are a group at risk of experiencing high blood glucose levels with increasing age. The purpose of the study was to analyze the relationship between physical activity and central obesity on hyperglycemia in adult women. The type of research is quantitative with a cross-sectional design on adult women at the Telaga Biru Public Health Center, Gorontalo Regency in 2019. The sample size is 248 people using purposive sampling. The method of collecting physical activity data is measured using a Physical Activity Level (PAL) questionnaire, central obesity is measuring waist circumference, and current blood glucose levels for hyperglycemic status. The statistical test is the chi-square test with 95% CI. The results showed that physical activity included in the light category was very high at 91.1% and central obesity status was also high at 61,3%. The results of current blood glucose levels showed that respondents who experienced hyperglycemia were low at only 15,3%. Physical activity had no significant association with hyperglycemia (p= 0,142), central obesity had a significant association with hyperglycemia (p= 0,005). The conclusion is that central obesity has a significant relationship with the incidence of hyperglycemia in adult women with an OR value of 3,52
Оценка вертикальной миграции водорастворимых компонентов пироугля сельскохозяйственных отходов как источника доступного органического углерода
Authors: Ахметзянова Лейсан Габбасовна , Зиннатов Марат Рифатович , Гордеев Александр Сергеевич , Курицин Иван Николаевич , Камалова Алина Ринатовна , Карамова Камаля Октай кызы , Морозова Наталия Владимировна
Published: December 2021

Применение пироугля из сельскохозяйственных остатков растительного происхождения может служить эффективным пролонгированным источником доступного углерода. В ходе эксперимента проведено лабораторное моделирование процесса вертикальной миграции пироугля в субстрат и водную фазу. Объектом исследования являлся пироуголь кукурузной соломы, полученный при 400 °C. Такое сырьё было выбрано по причине универсальности и доступности в условиях АПК Татарстана. В качестве субстрата в эксперименте использован оксид алюминия. Оценен процесс миграции органического углерода в промывном режиме. Часть органического углерода вымылась водой и частично перешла в субстрат, другая часть имеет потенциальную возможность перехода в субстрат или водную вытяжку. Пироуголь способен служить источником углерода как в краткосрочной, так и в долгосрочной перспективе.
‘We thought we were friends!’: Franco-British bilateral diplomacy and the shock of Brexit
Authors: Drake Helen , Schnapper Pauline
Published: December 2021

The British vote to leave the European Union in 2016 shook the Franco-British bilateral relationship (FBBR) to its core and led to unexpected tensions, considering the depth of cooperation between the two countries in many fields, and their geography. In this article we analyse the impact of Brexit on the FBBR to date, including the likely aftershocks. We focus on the 2017-2020 Brexit negotiations themselves, and on the matters that escaped those negotiations but which are core to the FBBR namely: security and defence; borders and migration. We draw on a number of high-level interviews with French and British officials and on literatures of contemporary diplomacy to ask how the new environment for the FBBR challenges traditional ways of conducting bilateral diplomacy outside of the multilateral framework provided by the European Union.
The Role of Nursing Homes Architectural Design in Mitigating the Risk of COVID-19 Pandemics: The Case of Slovenia
Authors: Žegarac Leskovar Vesna , Skalicky Klemenčič Vanja
Published: December 2021

Currently, many older people live in institutions for various social and health reasons. In Slovenia, this proportion is almost 5% of the population aged 65 and over. In the COVID-19 pandemic, the elderly proved to be the most vulnerable social group, as they are exposed to a number of comorbidities that increase the risk of mortality. At that time, nursing homes represented one of the most critical types of housing, as seen from a disproportionate number of infections and deaths among nursing home residents worldwide, including Slovenia. During the emergency, a number of safety protocols had to be followed to prevent the spread of infection. Unfortunately, it turned out that while the safety measures protected the nursing home residents, they also had a negative effect on their mental health, mainly due to isolation and social distancing. It follows that especially in times of epidemics of infectious respiratory diseases, the quality of life in nursing homes requires special attention. In this context, it is also necessary to consider whether and how an appropriate architectural design can help mitigating the spread of infections, while at the same time enable older people to live in dignity and with a minimum of social exclusion. To this end, the present study examined 97 nursing homes in Slovenia, analysing the number of infections in nursing homes and their correlation with the degree of infection in the corresponding region in Slovenia. Additionally, 2 nursing homes were studied in more detail with the use of newly developed “Safe and Connected” evaluation tool, analysing the architectural features of each building. The advantages identified so far include living in smaller units, single rooms with balconies, the possibility of using green open spaces and the use of an adequate ventilation. Conclusions of this study are useful for further consideration of design of new nursing homes and the refurbishment of existing ones.
Information and communication technologies for intelligent control of ground unmanned multipur-pose vehicles
Authors: Nikonov Oleh
Published: December 2021

At present, there is a situation when the practice of creating modern devices, units and systems of ground unmanned vehicles (GUV) has preceded the theory of information analysis and synthesis of complex systems. Some existing solutions for the information support of the GUV need to be generalized, standardized and unified, the definition of new special requirements for the creation of computer systems and networks in transport should be made. Therefore, it is necessary and actual to develop information and communication technology for intelligent control of multi-purpose GUV. Goal. The purpose of the article is to develop information and communication technology for intelligent control of multi-purpose GUV, which work in conditions of intensive loads, difficult operating conditions, increased responsibility of mechanisms, resulting in reduced human losses and energy consumption, increased machine reliability and control accuracy. Methodology. The methodology of tasks is based on the use of a synergetic approach to the creation of information and communication technology for intelligent control of multi-purpose GUV, as the development of a systematic approach taking into account the adaptation and integration of the vehicle to transport infrastructure and/or rough terrain. The principles of synergetics underlie the construction of mechatronic systems – a combination in one unit of components of different technical nature (mechanical, electrical, computer), which adaptively interact with the external environment as a single functional and structural organism. The synergetic approach deals with phenomena and processes, as a result of which the system – as a whole – may have properties that none of the parts has. Results. The concept of intelligent control of multi-purpose GUV on the basis of artificial hybrid neuro-phase regulators with the use of cloud computing services and deep learning technology is proposed, substantiated and implemented, which allows to qualitatively increase the efficiency of both one vehicle and the transport system on the base combining a synergetic approach and evolutionary methods of learning multilayer artificial neural networks by objectively forming the architecture of these networks on the basis of learning functionalities and appropriate control objectives. Originality. Use of cloud computing services based on deep learning for intelligent control technology of GUV. Practical value. The proposed information and communication technology of intelligent control of multi-purpose GUV will significantly reduce energy consumption, psychophysical stress on crew members, as well as increase the accuracy of location.
Analyzing the thermostabilization systems of lithi-um-ion traction batteries of electric vehicles
Authors: Serikov Georgy , Serikova Irina
Published: December 2021

Problem. Possible implementations of thermal stabilization systems for traction batteries of electric vehicles are considered. The analysis of possibilities to increase the efficiency of using lithium-ion rechargeable batteries at the expense of their temperature stabilization is carried out. The influence of the temperature factor on the useful capacity of traction batteries is shown. The microcontroller system of temperature stabilization of double action with function of the timer allowing to establish prematurely a mode of both cooling, and heating of storage batteries is offered. Methodology. The methods of theoretical basic electrical engineering have been developed in the production and calculation of circuits as well as the classical methods of statistics of signals from ADC. Results. The technique of processing information from the current, voltage and temperature sensors using a mathematical apparatus without using harmonic analysis is presented. The hardware implementation of the proposed method allows the use of simplified computing tools. Originality. Complex analysis of the data obtained from the current, voltage and temperature sensors is carried out. During the analysis, the range of velocities with stable operation of the measurement system was determined. Based on the data obtained, it is concluded that the use of a horn antenna as a concentrator substantially eliminates lateral interference and extends the range of possible velocity measurements. It is shown that the level of sampling significantly affects the upper limit of the measurement temperature. Practical value. The following results were obtained:

- minimizing the harmful effects of negative temperatures on the battery capacity is possible through the use of preheating;

- the system of temperature stabilization should be performed with the possibility of reversing the mode of circulation of thermal energy;

- simplification of the process of determining the temperature is possible due to indirect measurements of the internal resistance of the heater;

- in the case of pulse-width  control, the service life of the heaters increases, and the heating time is reduced at constant power consumption;

- application of the microprocessor system allows to increase functionality and flexibility of adjustment of the heating unit under various traction batteries.
Project as a method of teaching in higher education
Authors: Voronova Ye.
Published: December 2021

The article shows that the main goal of the project method is to provide students with the opportunity to acquire independently knowledge in the process of solving practical problems or problems requiring the integration of knowledge from various subject areas. The teacher in the project is assigned the role of a coordinator, expert, additional source of information At the same time it is underlined that this , practically new technology, is  directed to purposeful, generally independent activity of students, carried out under the flexible guidance of a teacher, aimed at solving a communicative research or socially significant professional problem and to obtain a specific result in the form of a material and / or ideal product. Goal. The purpose of the article is to show the importance of using the method of project. The project method in teaching a foreign language in a non-language (technical) university is a didactic means of activating the cognitive activity of future engineers, a method of developing their creativity, which also contributes to the formation of certain personal qualities The main purpose of the project method is to provide students with the opportunity to independently acquire knowledge independently in the process of solving practical problems or problems that require the integration of knowledge from different subject areas. Methodology. Various forms of presentation of educational material within the project method stimulating the development of such qualities of creativity as: and originality of thought, development of ideas, active creative self-development, intellectual independence of students is revealed in the article. Results. The method of projects helps take into account the individual characteristics of students, and it significantly contributes to the development of skills and skills in teamwork, decision-making and presentation in business and professional situations.
Defining the rational installation position for the discharging unit of the bucketless rotary imple-ment in the trenching excavator
Authors: Musiiko Vladimir , Koval Andrii , Olieinikova Oleksandrа
Published: December 2021

The increasing volumes of the earthworks performed by trenching excavators during the creation of the lengthy excavations in the soil for the pipelines of different sizes and other purposes create the need to improve the excavators, to create new highly productive machines of the fundamentally new construction. The goal of this work is to increase the performance of trenching excavators equipped with the bucketless rotary implement by improving the process of the soil discharging from the implement. To achieve this goal it is required to reveal the physical essence of the soil excavation by the bucketless rotary implement and based on the performed study to determine the rational installation position for the discharging unit of the bucketless rotor. Methodology. The scientific hypothesis is that discharging of the inner circular cavities of the bucketless rotor during the trench digging and the movement of the excavated soil to the side from the trench is possible by means of rational use of the flow header pressure of the soil that is being transported in the rotor from the excavation. The study is performed with analytical methods using basic principles of the theoretical mechanics, flowing medium statics, force analysis. Results. The study confirms the scientific hypothesis of the possibility to discharge the bucketless rotary implements of the trenching excavators by using the flow header pressure of the excavated soil that is transported by the rotor from the excavation,  rational installation position of the discharging unit of the implement is defined. Originality. The scientific novelty of the study lays in the rationale and confirmation of the possi-bility to excavate and transport the soil from the excavation with the implements of the rotary trenching excavators with continuous flow and not with the separate portions. Practical value. Practical value lays in ensuring the 2-5 times performance increase of the excavation using the bucketless rotary implements.
Development of a method for designing specialized machinery based on a hinge tractor
Authors: Shcherbak Оleg , Suminov Andrey , Khachaturian Sergey
Published: December 2021

The method of designing frames of special machines for road construction and public utilities is considered, which allows you to design special machines with a given level of reliability and durability. The technique allows using modern computer modeling systems to carry out constructive refinement of the base tractor frame using experimental and mathematical modeling data. Using the design feature of tractors of the T–150K family, namely the presence of an articulated joint, it is possible, using a modular principle, to quickly design various machines for various industries. However, in order to design reliable machines, one must have a methodology for designing such machines. There is currently no such technique. When designing special machines, designers perform calculations only for working equipment. But as practice shows, the critical elements of the machine in this case, the support of the vertical hinge of the tractor frame during the operation of the pressurized machine (wheeled bulldozer and front loader), experience shock loads that lead to the destruction of the frame of the base tractor. The purpose of the article is to develop a methodology for designing a complex of road–building machines on the basis of mass–produced tractors with an articulated frame produced by public limited company "KhTZ".
The analysis of modern tools of positioning of the working mechanism road construction ma-chines on building
Authors: Yefymenko Oleksandr , Pluhina Tetiana
Published: December 2021

The task of positioning the working mechanisms CRM at this time is not enough. As a result of the analysis the purpose of research is set, namely: to increase of functioning efficiency mechanisms CRM with working environment using mathematical models and adaptation algorithm in a limited time decision. Such methods of analysis include fractal analysis, neural network method, fuzzy set method, geostatistical data analysis. The element base of positioning systems and benefits of implementation are substantiated. The use of a GPS intensifier makes it possible to predict the work of actuators CRM in real time. The result of the research is algorithm of positioning the working mechanisms CRM: determination of the location of the base CRM in a 3-dimensional coordinate system; filtering measurements; predicting the position of the working mechanism (the algorithm for choosing a solution for the state of the monitored object is based on both the probability of obtaining certain results and their usefulness). The originality lies in the fact that the using modern information and software tools allows to describe the trajectory in the coordinate system of the base machine in accordance with the point measurement, and describe the relationship between changed coordinates, which makes it possible to model and predict the workflow. Proposals for the use of software in positioning systems, which provides adaptive optimization and advantages of introduction of the newest technologies of intellectualization of work processes.
Predictive indicators of an unfavorable prognosis for the restoration of laryngeal functions in unilateral lesions of the recurrent laryngeal nerve in thyroid surgery
Authors: Solomennikova N. V. , Deeva J. V. , Palamarchuk V. O. , Kuts V. V.
Published: December 2021

Recurrent laryngeal nerve (RLN) damage in thyroid surgery is a very dangerous complication. An otolaryngologist, especially at pri­mary care institutions,should administer conservative or surgical treatment in a timely manner and depending on the type of nerve damage (transient, permanent), i. e., to analyze possible prognosis of the disease. Only few studies to predict disease developmentin RLN have been performed. One of the most modern and informative methods is laryngeal electromyography using needle electrodes, but despite the sufficient number of patients with this pathology, in most medical institutions in Ukraine it is not performed, given the technical difficulties of implementation, invasiveness and difficulty in interpreting the results of this method.Aim — to analyze the laryngoscopic signs of paresis and paralysis of the larynx in thyroid surgery and to identify the most significant from them, which together can serve as prognostic criteria of the lack of recovery of laryngeal mobility (paralysis).Materials and methods. A single-site prospective study was conducted in the years 2018—2021 that involved 164 patients with postoperative laryngeal movement disorders, who were divided into two groups: subjects with laryngeal paralysis (n = 33) and patients with laryngeal paresis (n = 131). All patients underwent phoniatric examination. The following signs have been identified: general signs, including age, number of operations, scope of surgical intervention, and 18 laryngoscopicsigns, each of them had two to seven grades. For the convenience, the grades were coded with numbers and, if possible, arranged in ascending order of severity. The obtained results were processed with Fisher angular transformation.Results. Among 18 laryngoscopic and general signs, 10main (predictors) were identified, that affect the absence or presence of laryngeal paralysis. They included:elements of mobility of the paralyzed vocal cords (VC) (absent), flotation of the «paralyzed» VC (insignificant and pronounced), mobility of the arytenoid cartilage (absent), closure of the VC (complete non-closure), synchronicity of oscillations VC (absence of movement of the paralyzed VC), restriction of the movement of the «paralyzed» VC (absent (the GE is motionless), level of the VC in the vertical plane (not on the same level), the tension of the median edge of the VC (incurvate), patient’s age > 45 years, the position of the «paralyzed» VC (median and intermedian). The mathematical analysis showed that none of the isolated laryngoscopic signs can be used as an independent criterion in assessing the predictions of the laryngeal mobilityrestoration.Conclusions. Prognostic laryngoscopic signs of recurrent laryngeal nerve damage in the thyroid surgery allow to create a prognostic model of recovery or lack of recovery of laryngeal motility, which is important for the appointment of timely adequate treatment.
Laser doppler flowmetry as the advanced non-invasive method of evaluation оf microcirculation status in patients with diabetes mellitus
Authors: Shaienko Z.
Published: December 2021

Currently, the problem of diabetes mellitus (DM) is one of the most important medical and social challenges worldwide. This is primarily due to the widespread prevalence of the disease and tendency to further increase in the incidence of diabetes mellitus.Systemic microcirculatory disorders play an impor­tant role in the pathogenesis of DM complications. They lead to the development of microangiopathy and neuropathy through the primary lesion of vessels involved in the blood supply of the peripheral parts of the nervous system. Currently, less than one-third of physicians recognize signs of peripheral neuropathy associated with diabetes. Untimely diagnosis contributes significantly to high morbidity, disability, and mortality.The authorinvestigates the experience of the use of laser Doppler flowmetry (LDF) in clinical practice as a method of studying the state of the microcirculatory bed in patients with diabetes mellitus.LDF is a non-invasive quantitative method of microcirculation assessment; its capabilities include the analysis of microcirculatory rhythms and functional testing with different types of provocative effects, which provides with investigating the state of regulatory mechanisms of microcirculation. The prevention and treatment of various microcirculatory disorders is one of the most important problems of medical practice. The difficulties of studying the microcirculation are caused by the very small size of microvessels and strong ramification of intra-organic vascular networks. The use of LDF in scientific research will make it possible toreveal the DM-specific changes in microcir­culatory bed functioning. The findings of some studies suggest that microcirculatory disorders are not only a pathogenetic link in the development of complications, but they are also observed in patients with early disorders of carbohydrate metabolism and may precede the manifestation of diabetes. However, the method has not yet become widespread in clinical practice.
Congenital hypothalamic hypogonadism — a Kallmann syndrome in boys. Clinical cases
Authors: Globa E. V. , Zelinska N. B. , Yengovatova V. A. , Horosha O. A. , Pogadayeva N. L. , Peretyatko І. О.
Published: December 2021

Central hypogonadism (CH) is a rare disease that occurs with a frequency of 1 : 8000 in women and 1 : 4000 in men. In 60 % of cases of CH, it is caused by Kallmann syndrome (KS) — a disease in which hypogonadotropic hypogonadism is combined with olfactory disorders (hyposmia or anosmia).Aim — to study clinical features, principles of diagnosis of CH/KS and evaluation of the effectiveness of various treatment. Materials and methods. 4 cases with CH/KS from three families had been described. Laboratory and instrumental investigations were used to confirm the KS; genetic diagnosis was performed using targeted next-generation sequencing (tNGS hypogonadotropic panel).Results. Patients with CH/KS had a wide spectrum of genital disorders (micropenia, cryptorchidism, microorchidism), which appeared at different age. Extragenital pathology was found in three of four patients: namely disorders of kidney, eye, respiratory system, hypoparathyroidism, hypothyroidism and epilepsy. It should be noted that all patients had olfactory disorders, which appeared in two of them only during a detailed survey after receiving genetic testing. In all patients, the diagnosis of CH was confirmed by the test with triptorelin 0.1. Also, all patients who underwent densitometry were found to have significant osteoporosis. In three patients, genetic testing confirmed hemizygous pathogenic variants in ANOS1 gene, while in one patient a heterozygous variant in FGFR1 gene was confirmed. After treatment with chorionic gonadotropin (HCG), two patients responded positively, with a descent of the testicles into the scrotum and an increase of testosterone level and testicular volume. However, in the other two patients there was no positive trend in treatment with HCG, therefore, the use of recombinant human FSH (r-FSH) in the form of priming and then further — in combination with HCG may be considered. Although the presence of severe microorchidism, cryptorchidism, low levels of AMH, inhibin B, and an unsatisfactory response to the previous treatment with HCG indicates extremely unfavorable prognosis. Therefore, in order to achieve the fertility in some patients with CH/KS, the most likely attempt is the use of assisted reproductive technologies.Conclusions. The leading problem in the treatment of patients with KS is their different response to hormone therapy, including different manifestations of the disease.
Aspectos metodológicos e operacionais do Estágio Extramural em universidade privada no Nordeste brasileiro
Authors: Pequeno Lucianna Leite , Marques Paulo Leonardo Ponte , Monte Ingrid Cordeiro Monte
Published: December 2021

Este relato tem por objetivo descrever os aspectos metodológicos e operacionais de um Estágio Curricular Supervisionado. O cenário foi de uma universidade privada do município de Fortaleza, Ceará, e os campos de estágio externos pactuados com órgãos governamentais e instituições não governamentais. A referência foi o período dos últimos cinco anos (2016 a 2021). O estágio ocorre com carga horária de 144 horas e operacionalização em três momentos: Prólogo (10% do tempo), Mundo Real (80%) e Epílogo (10%). No Prólogo são desenvolvidas atividades de resgate e nivelamento de conhecimentos e ações realizadas durante o curso. A operacionalização do estágio, a partir da articulação teoria e prática, ocorre no momento do Mundo Real. Os discentes são alocados em turmas de 5 a 6 componentes para atuar 8 horas por semana em campos de estágio do Sistema Único de Saúde. São desenvolvidas ações coletivas em espaços sociais e procedimentos clínico-assistenciais nos consultórios odontológicos das Unidades de Saúde. Mediado pelo docente e preceptor, ocorrem feedbacks em grupo para troca de experiências semanalmente. No Epílogo há o fechamento do estágio, por meio da devolutiva em forma de apresentação da Mostra e de relatórios das atividades realizadas. A diversidade de estratégias metodológicas e operacionais do estágio possibilita uma imersão diferenciada dos discentes nos serviços públicos de saúde, proporcionando que a teoria encontre a prática para aquisição de competências que serão aplicadas no Mundo Real.
Pengaruh Komunikasi Organisasi terhadap Kinerja Karyawan di PT. Feva Indonesia
Authors: Islami Annisa Nur , Palupi Merry Fridha Tri , Romadhan Mohammad Insan
Published: December 2021

This study examines the influence of organizational communication on employee performance at PT. Feva Indonesia. Organizational communication has an important meaning in delivering messages within the scope of the organization. One of the organizational behaviors in which there is the delivery of person and information connecting aspects. Good communication fluency depends on a person's ability to communicate and communicate it. The problems that occur are because the communication process is not going well so that information from superiors to employees can cause a misunderstanding because the information conveyed is not understood. With good organizational communication, it is hoped that employee performance will also increase, because it is not an easy thing to improve employee performance. This type of quantitative research uses the total population of employees of PT. Feva Indonesia. Researchers have a role as key informants of 70 employees. The total population is less than 100 people, taken 70 respondents or total sampling. The research conclusion is that organizational communication variables have a significant effect on company performance.Keywords: organizational communication, employee performance
Perilaku Komunikasi Orang Tua dan Anak Selama Sekolah Online di masa Pandemi Covid-19 (Studi Kasus Pada Masyarakat Kecamatan Oebobo Kota Kupang Nusa Tenggara Timur)
Authors: Mas’amah Mas’amah , Adu Apris A.
Published: December 2021

Wabah covid-19 telah merubah kebiasaan manusia, termasuk bidang pendidikan. Kondisi ini menyebabkan perubahan cara berkomunikasi diantara orang tua dan anak. Penelitian ini bertujuan untuk mengetahui perilaku komunikasi orang tua dan anak selama sekolah online, serta untuk mengetahui hambatan dan solusi selama sekolah online. Konsep yang digunakan adalah perilaku komunikasi. Metode penelitian studi kasus. Informan penelitian 5 orang tua yang mempunyai anak sekolah online dan 5 anak yang sedang mengikuti sekolah online. Pengumpulan data dilakukan melalui wawancara, observasi serta dokumentasi. Data dianalisis dengan model interaktif Miles dan Huberman. Temuan penelitian ini yakni: perilaku komunikasi yang dilakukan orang tua dan anak selama sekolah online adalah komunikasi verbal dan non verbal. Sedangkan hambatan yang dihadapi selama sekolah online adalah tidak memiliki hp android, tidak mempunyai paket data, jaringan internet tidak stabil, tidak melek teknologi, anak-anak tidak memahami materi yang dikirimkan guru, dan anak-anak kurang fokus saat belajar. Sedangkan cara mengatasi hambatan tersebut adalah orang tua mengambil materi pelajaran dan tugas di sekolah, membeli hp android, berusaha melek teknologi, orag tua berusaha menjelaskan materi yang belum di pahami oleh anak, dan anak berusaha bertanya pada teman, guru dan mencari informasi di internet, serta orang tua selalu berupaya mendorong anak-anak tetap fokus belajar.Kata Kunci: Perilaku Komunikasi, Orang Tua dan Anak, Sekolah OnLine
Two Anthems for the Georgian Court, Part 1
Authors: Boyce William
Published: December 2021

William Boyce wrote these two anthems in 1760 and 1761, at the height of his career. Both are scored for large chorus and orchestra. The Souls of the Righteous was written for the funeral of George II and first performed on 11 November 1760.
BIOCHEMICAL REACTIONS CATALYZED BY CYCLODEXTRINGLUCANOTRANSFERASES
Authors:   Ufa Institute of Biology of the Ufa Federal Research Centre of the Russian Academy of Sciences, Milman P.Yu. , Gilvanova E.A. ,   Ufa Institute of Biology of the Ufa Federal Research Centre of the Russian Academy of Sciences
Published: December 2021

Cyclodextringlucanotransferase (CGTase, CF 2.4.1.19) is a unique enzyme that performs reversible intermolecular as well as intramolecular transglycosylation and executes cyclization, binding and disproportionation of maltooligosaccharides. The nature and intensity of transformations depends on the genetic variety of the enzyme. Thanks to a wide range of biochemical reactions catalyzed by Lipases, the solubility in water, bioavailability, absorption and biological activity of synthesized products, which are widely used in food additives, detergents, medical and cosmetic products, are improved. This review describes the enzymatic reactions carried out by CGTases.
METHOD FOR DETERMINING THE HYPER SENSITIVE RESPONSE OF POTATO PLANTS TO CLUSTERS OF THE COLORADO POTATO BEETLE EGGS FOR USE IN BREEDING
Authors:   Bashkir Research Institute of Agriculture, Ufa Federal Research Center, Russian Academy of Sciences, Mardanshin I.S. , Sorokan A.V. ,   Institute of Biochemistry and Genetics, Ufa Federal Research Center, Russian Academy of Sciences, Gordeev A.A. ,   Bashkir State Pedagogical University named after M. Akmulla, Benkovskaya G.V. ,   Institute of Biochemistry and Genetics, Ufa Federal Research Center, Russian Academy of Sciences
Published: December 2021

The creation of new varieties of potato revealing innate highly effective mechanisms of protection against Colo-rado potato beetle is an urgent task of breeding, which requires the development of methods that allow standardizing certain plant responses to different aspects of the influence of this phytophage under laboratory conditions. The laying of eggs by insects on the surface of plant laves leads to the development of an intense protective reaction and the production of ovicides, intensive death of tissue, followed by the loss of eggs or their drying. To simulate the laying of eggs on the leaves, we used a washout from the surface of the clutches of the Colorado potato beetle containing a pool of elicitors of plant defense reactions. On cultivars Bashkirsky (high resistance to the Colorado potato beetle) and Udacha (medium-resistant cultivar), drying of leaf areas was observed in response to the treatment of the lower surface of the leaf blade, and on cultivar Rannyaya rosa (unstable cultivar), there was no reaction. The dried spots on the leaf blade were strictly limited to the place where the wash was applied. It was found that the formation of reactive oxygen species in response to the application of the washout occurs only on potato varieties Bashkirsky and Udacha with the development of a hypersensitive response, which corresponded to the drying of leaf blades observed under the field conditions at the sites of clutch attachment. Localization of hydrogen peroxide and superoxide anion occurs in the cells of the vascular bundles and adjacent tissues. On the Rannyaya Rosa cultivar, the application of the washout did not lead to the accumulation of reactive oxygen spe-cies in the leaf tissue and the drying of the leaves.
DEGRADATION OF PHENOL AND 2,4 DICHLOROPHENOL BY BACTERIA OF THE SPECIES RAOULTELLA PLANTICOLA
Authors:   Ufa Institute of Biology of the Ufa Federal Research Centre of the Russian Academy of Sciences, Korobov V.V. , Zhurenko E.I. ,   Ufa Institute of Biology of the Ufa Federal Research Centre of the Russian Academy of Sciences, Zharikova N.V. ,   Ufa Institute of Biology of the Ufa Federal Research Centre of the Russian Academy of Sciences, Markusheva T.V. ,   Ufa Institute of Biology of the Ufa Federal Research Centre of the Russian Academy of Sciences
Published: December 2021

The ability of three natural isolates of the species Raoultella planticola to separately use phenol and 2,4-dichlorophenol (2,4-DCP) as the only source of carbon and energy was studied. All strains converted phenol, but R. planticola 36T was the most effective and utilized 97% of the substrate. Due to the higher toxicity of 2,4-DCP, only one strain 33-4ch could use this substrate with a final efficiency of 73%. The strains did not antagonize each other, which indicates the possibility of their combined use for cleaning the environment from chloroaromatic pollutants.
SCREENING OF tod C1 GENE IN THE BACTERIA OF TECHNOGENIC ECOTOPES
Authors:   Ufa Institute of Biology of the Ufa Federal Research Centre of the Russian Academy of Sciences, Adelgareeva A. Yu. , Starikov S.N. ,   Ufa Institute of Biology of the Ufa Federal Research Centre of the Russian Academy of Sciences, Markusheva T.V. ,   Ufa Institute of Biology of the Ufa Federal Research Centre of the Russian Academy of Sciences
Published: December 2021

The todC1 gene was screened in microorganisms of the Republic of Bashkortostan industrial ecotopes. The todC1-like sequences were not found in the bacteria of the Bacillus, Cellulosimicrobium, Citrobacter, Enterobacter, Gordonia, Lysinibacillus, Paenibacillus, Pseudomonas, Raoultella, Rhodococcus and Serratia genera. The todC1 gene was detected by PCR in the bacteria of Paenibacillus genus.
Locating places for repatriated burial: A case study from Ngarrindjeri ruwe, South Australia
Authors: Wallis Lynley , Moffat Ian , Trevorrow George , Massey Toni
Published: December 2021

In this ingenious co-operative case study, archaeologists and Indigenous peoples use geophysical survey to scan suitable places for the reburial of repatriated human remains. The process is also building a procedure for the low impact and respectful research of early Indigenous burial locations.
Letter to the editors on termite stone lines
Authors: Smith Mike , Ward Ingrid , Moffat Ian
Published: December 2021

To the Editors,Termite activity is ubiquitous in Australia's seasonally wet tropics, and some degree of termite disturbance is inevitable in archaeological sites across this region. Our paper specifically focused on developing guidelines for identifying situations where termite activity has been sufficient to create a stone line that mimics an archaeological horizon (Smith et al., 2020). In a critique, Williams et al. (2020) arbitrarily discount the criteria we propose for discriminating between these phenomena. Here, we respond to their comments and discuss the role of luminescence dating in identifying bioturbation by termites
Strategi pemasaran
Authors: H Yuris Huswatun
Published: December 2021

pemasaran untuk tujuan meningkatkan hasil produk yaitu melalui kegiatan promosi.Sebagaimana diketahui bahwa keadaan dunia usaha bersifat dinamis,yang selalu mengalami perubahan yang terjadi setiap saat dana dan keterkaitanantara satu dengan yang lainnya.Oleh karena itu strategi pemasaran mempunyaiperanan yang sangat penting untuk keberhasilan perusahaan umumnya dan padabidang pemasaran khususnyaDisamping itu strategi.
Indigenous built structures and anthropogenic impacts on the stratigraphy of Northern Australian rockshelters: insights from Malarakk 1, north western Arnhem Land
Authors: Wesley Daryl , Litster Mirani , Moffat Ian , O’Connor Sue
Published: December 2021

Malarrak 1 is currently the northernmost excavated rockshelter on the Australian mainland, located in the Wellington Range in north western Arnhem Land. The site contains a rich late Holocene deposit, with extensive contact rock art, stone artefacts, shell, bone, contact materials, ancestral human remains, and other cultural material. Excavation of the Malarrak 1 rockshelter and analysis of its sediments revealed many impacts on site formation processes within the deposit. We attribute the disturbance to possible erosion or sediment deposition during periods of intense rainfall and also to the construction of timber structures within the site. This is supported by modern and historical observations and is the focus of this paper. The extent of the disturbance to Malarrak 1 provides a cautionary tale for other excavations in the region that may be affected by similar Indigenous site occupation, as these anthropogenic activities enhance the risk of further impacts arising from biological and geomorphological processes that can impinge on the stratigraphic integrity of the cultural deposits.