bluuebunny/crossref_metadata_2025 huggingface dataset:
Relationships between a Teacher and Parents and Building a Friendly, Educational Space for a Kindergarten Child: Narratives of Male Preschool Teachers
Authors: Koperna Paulina
Published: September 2023

The teacher-parent cooperation is an inseparable part of teachers’ work in preschool education. Although important for kindergarten, it is also often not satisfying. The aim of the qualitative research was to recognize and understand the experiences of shaping and developing relationships with parents from the perspective of male preschool teachers and to answer the question of how do they perceive and understand their relationship with parents of kindergarten children. The research based on narrative interviews was conducted in 2019–2020 among 18 male preschool teachers from Poland. The categories describing the development of relationships between male teachers and parents, ways of shaping them from a time perspective, and important values were distinguished. The results show that the conscious care of the relationship with parents by male teachers contributes to the creation of friendly educational space for children. Experiences related to relations with parents and the meanings given to them by men working in kindergartens were referred to social constructivism as a legitimate interpretation trend. Highlighted category of place understood as the material space of the kindergarten and the space of friendly social relations also made it possible to embed the narratives in the pedagogy of place as understood by Maria Mendel.
The Aspect of Relationship within Constructivist Early Childhood Education – an Analysis of Teachers’ Experiences
Authors: Jarkiewicz Anna , Szulewicz Elżbieta
Published: September 2023

This article presents the results of our own research. Qualitative analysis was made of interviews in which early childhood education teachers, who declare and use a constructivist approach in their work, talk about their experiences in introducing and working with this approach. The interviews were conducted in 2022 with five female teachers. The analysis of the empirical material concerned the identification of challenges, difficulties, and limitations in implementing the constructivist approach in early childhood education. The focus was on the resulting modifications in the relationship between the teacher and other parties, i.e. teacher–school, teacher–student, and teacher–parent. The research results indicate that a relatively simple relationship conversion occurs in the teacher–school interaction (the favourable attitude of the school management of course determines the simplicity of this modification). Much more difficult modifications concern teacher–student or teacher–parent interactions, which are conditioned by a number of elements, including the specific socio-cultural context and the attitudes to education and teachers ascribed by the participants within it.
Formal and Informal Strategies in the Work of Early Years Practitioner
Authors: Heland-Kurzak Krystyna
Published: September 2023

Introduction: The article concerns the strategies in the work of early years practitioners in terms of the relationships they create with children, colleagues at work, management or parents. The description of tacit knowledge is presented in the light of the nursery’s resources, not its weaknesses. Research Aim: To show how relational tacit knowledge is visible in the work of early years practitioners in nurseries. Method: The study involved 20 early years practitioners in Warsaw, it was an in-depth interview. The study used the framework of Collins’ theory of explicit and tacit knowledge. The analysis of the interview data was carried out using the MAXQDA 2022 software. The part of the interview concerning the research results presented in this article contained 12 questions. Results: When analyzing the coded fragments about the strategies used in conversations and cooperation with the nursery management, they were divided into two parts. The first part of the strategy is applying them to a manager who is considered to be a trustworthy, helpful, committed, understanding person. The second part of the strategy is to apply them to a manager who is considered to be unpredictable, unorganized, unjust in financial management, unjust in managing employee resources, and uncommitted. Most early years practitioners declare an open strategy of conversation towards their colleagues and children, based on the directness of the message and honesty of expression. The early years practitioners declare that they use the sandwich method with their parents. Conclusions: It was observed that the greatest intensification of informal strategies occurs in the relationship between the early years practitioners and parents. In the statements of the respondents, it was noticeable that even if relational tacit knowledge tries to see the light of day, it is basically one-sided in the form of requirements for parents to meet the expectations of the nursery. It is difficult for parents to implement the rules prevailing in the nursery to the rules prevailing at home.
The Social Climate of the Classroom in the Context of the Diagnosis of the Needs of Students in the Field of School Prevention
Authors: Kusztal Justyna Joanna , Piasecka Małgorzata , Czaczuń Katarzyna
Published: September 2023

Introduction: The article presents the results of a diagnostic study covering the needs of fourth-class students at Kraków primary schools in the field of school prevention. Conducting preventive activities in schools and educational institutions is a statutory obligation, and the conditions impacting such activities lie in many areas, such as the adopted concept of prevention, school procedures, legal conditions, and the local system of prevention, and in the existing social climate in the school classroom. The study of the strengths and weaknesses of the social climate of the class is an important element of the diagnosis of the class, which is a necessary condition, defined by law, for the design, implementation, and evaluation of the educational-preventive program of the school and educational institution. Research Aim: The purpose of the study was to diagnose the social climate of the classroom directed at formulating guidelines and recommendations for conducting an educational and preventive program in the school classroom. Method: The research method was analysis of the products of the subjects with the help of the “draw-write” diagnostic technique developed by Woynarowska and Woynarowska-Sołdan. Results: The results of the research include the strengths and weaknesses of the social climate most often indicated by students allowing us to identify the priority problems of the class, which can be risk factors for risky behaviour, and help us to design adequate preventive measures. Conclusions: Findings from the survey indicate that the strengths of the social climate of the classroom indicated by students are elements of the classroom/school environment, most often material objects, well associated by students with classroom games, spending time together and having fun, while less often students indicated relationships with classmates and teachers. Among weaknesses, students most often cited negatively assessed student behaviour during breaks and in class. The priority problem in all the classes surveyed was aggressive behaviour by students, in verbal and physical forms, resulting from low communication skills and ignorance of the rules of group behaviour and cooperation.
Care and Educational Activities of the Podkarpackie Hospice for Children Foundation in 2006-2021. Selected Examples
Authors: Barnaś-Baran Ewa
Published: September 2023

Introduction: The first hospice was established in 1967 by Cicely Saunders. Another important event was the establishment of a day centre for terminally ill patients in Sheffield at St Luke’s Hospice. In Poland, hospice care was developed on the initiative of Hanna Chrzanowska. A special type of this institution are children’s hospices. One of them is the Podkarpackie Hospice for Children Foundation, established in 2006. Research Aim: The aim of the research was to present the history of the establishment and development of the Podkarpackie Hospice for Children Foundation, as well as analyse examples of patient care and educational activities undertaken by the management, employees and teachers cooperating with the Foundation in the period 2006–2021. The methodology used involved a critical analysis of documents and source materials and a review of the literature on hospice care. Evidence-based Facts: Two periods can be identified in the history of the Podkarpackie Hospice for Children Foundation between 2006 and 2021. From 2006 to 2011, patient care was provided under the at-home hospice care system. Simultaneously, efforts were undertaken to organise a separate location to expand the assistance provided, which resulted in the establishment of an in-patient hospice in 2011, which implements a broader range of tasks of the Foundation, including Perinatal Hospice, which was created in response to public demand. Summary: Patient care and educational activity of the Foundation is carried out through its individual units, including the at-home, in-patient and perinatal hospice, as well as the regional care and therapy centre “Tęczowy Domek”, which implement the goals and tasks of the Foundation. In addition, the educational activity of the Volunteer Centre helps to breaking down stereotypes related to hospices.
Motivación laboral y su relación con el desempeño de colaboradores en empresa de rubro textil
Authors: Zapata Huamaní Zaira Abigail , Napán Ana Cecilia , Meza Rodríguez Rolando
Published: September 2023

Desde la perspectiva de este estudio, el objetivo de la investigación considera “determinar la relación de la motivación laboral con el desempeño de los colaboradores en Industrias Súper Sport S.R.L. - 2021”. Dentro de la metodología se desarrolló el diseño no experimental, de enfoque cuantitativo, alcance descriptivo correlacional. La muestra fue censal y la conformaron 105 colaboradores de Super Sport. Para el recojo de datos se utilizó la encuesta como técnica, de igual forma el cuestionario como instrumento con 36 ítems para ambas variables. Para el procesamiento de datos en el entorno inferencial según la prueba de normalidad se trabajó con el estadígrafo Rho de Spearman, encontrando correlaciones positivas. Para la hipótesis general la correlación hallada fue de (r=0,764) indicando que la relación es directa y positiva, concluyendo que la motivación laboral se relaciona significativamente con el desempeño laboral de los colaboradores en Industrias Súper Sport S.R.L - 2021.
The Noise of the News: Spectral Analysis of Early Swedish Television News 1958 - 1978.
Authors: Malmstedt Johan
Published: September 2023

Looking back on the very first year of television in Sweden, the head of programming Henrik Hahr celebrated having brought the world into “the living room of the viewer”. From the emergence of Swedish public service television in 1956 and onwards, the medium would be lauded as a window to the world. Yet, what noises came through this window? Shifting focus away from the visual content of television, this article explores and emphasizes the sonic dimensions of early Swedish news broadcasting. In the middle of the 20th century, the look, and the sound of the news were taking shape across television stations around the world. In Sweden, public service broadcasting was partly influenced by the backdrop of the cold war, and demands were formulated on a style of television that would be distinctive from the American and Soviet alternatives. This was a matter of images and audio in equal proportions. Deciding what kind of sound was added to the previously mute newsreels was at the heart of televised journalism. With a media monopoly running two competing news shows, the Swedish case offers insight into the establishment and differentiation of public service television aesthetics in the post-war era. Prior research has investigated the institutions, infrastructures, and ideas which shaped early Swedish television, but the very signals remain unexplored. This article introduces new methods for studying aural aesthetics in audiovisual media. By conducting various types of spectral visualization on recorded television news from 1958 until 1978, this analysis traces the sonic profile of the Swedish public service. The aim is to provide historical knowledge of how the news sounded and which aural experiences were promoted within the realm of the welfare state media monopoly. However, by drawing attention to the prospect of audio signal processing as a method for cultural-historical research, the purpose is also to make a methodological contribution to television studies at large.
Audiovisual Heritage and its Uses at the Swiss Public Broadcaster: A Dialogue on Opportunities and Constraints for Archives and Academics
Authors: Weber Anne-Katrin , Comte Simone , Vallotton François
Published: September 2023

Conjointly conceived by an archivist at the Radio Télévision Suisse (RTS, the French speaking PSB) and two media historians, this paper aims at discussing the diversity of uses of digitised AV heritage in Switzerland through the lenses of their professional experience. It focuses on the RTS as a particularly productive case study since the RTS has not only been a pioneer in digitising AV heritage and in promoting its holdings to the broader audience, but it also actively develops new tools for internal use, in particular speech to text technologies and more recently AI-based automation for image treatment and analysis, and datamining tools. Through a discussion of current projects at the RTS, the paper provides insights into the most recent uses and reuses of digitised AV heritage in Switzerland.
Editorial
Authors: Waysdorf Abby , Müller Eggo
Published: September 2023

This special issue of VIEW was inspired by a call from the final conference of the project “European History Reloaded: Curation and Appropriation of Digital Audiovisual Heritage” (CADEAH). The project brought together interdisciplinary expertise in the curation of digital audiovisual heritage, contemporary European history and Digital Humanities to study the ‘afterlife’ of digitized audiovisual heritage once it was made accessible and shared online, something that has seen a great deal of growth throughout the first two decades of this century. What happens to digitized audiovisual heritage once it is shared online? How does audiovisual heritage circulate online? To what extent do users re-use or re-mix audiovisual heritage? And, more specifically from an archival perspective: How do strategies of curation shape the appropriation of digitized heritage? What new perspectives on European history and identity do digital curations and appropriations of audiovisual heritage create? How can audiovisual archives better foster the re-use of Europe’s audiovisual heritage? With this issue we wanted to broaden our view and discuss our insights with scholars from diverse disciplines and with diverse professional backgrounds. These articles showcase the methodological and conceptual approaches that are being used across Europe to understand, and encourage, the use of audiovisual heritage, investigating contemporary practices of re-use and the ways that archives themselves think about these challenges.
Validation of a Visual Analog Scale for Loss of Smell as a Quick Test in Chronic Rhinosinusitis With Nasal Polyps
Authors: Alobid I , Calvo-Henríquez C , Viveros-Díez P , López-Chacón M , Rojas-Lechuga MJ , Langdon C , Marin C , Mullol J
Published: September 2023

Background and Objective: The diagnostic criteria of chronic rhinosinusitis with nasal polyps (CRSwNP) include olfactory dysfunction. We hypothesize that patients with CRSwNP can self-assess their sense of smell better using a visual analog scale (VAS) than using smell tests.
Methods: A controlled cross-sectional study was performed. Adults diagnosed with severe CRSwNP waiting for endoscopic sinus surgery were included. A cohort of healthy controls was also studied. All participants completed the Barcelona Smell Test 24 (BAST-24), the 22-item Sinonasal Outcomes Test 22 (SNOT-22), and a VAS for loss of smell. Patients with CRSwNP underwent blood testing (eosinophil count, total serum IgE), computed tomography (Lund-Mackay Score), and nasal endoscopy.
Results: The study population comprised 138 patients with severe CRSwNP and 40 controls. The BAST-24 identification score was strongly correlated with the VAS score in the CRSwNP group (p=–0.79, P<.001) but not in the control group (p=–0.14; P=.39), this difference between groups being statistically significant (P<.001). A significant correlation was found between SNOT-22 item 21 (loss of smell) and BAST-24 identification (p=–0.65, P<.001), this difference being statistically significant (Z=–2.43; P=.015). The area under the receiver operating curve was 0.85, with 72.5% sensitivity and 93.1% specificity.
Conclusion: This study demonstrates a potential role of the VAS score for the screening of olfactory dysfunction in severe CRSwNP in daily clinical practice.
Hacia una agenda de transición energética en el Perú: una propuesta
Authors: Gómez José Ramon , Elliot Patricia , Salazar Diez de Sollano Francisco Javier
Published: September 2023

El objetivo de esta nota es hacer una propuesta para la implementación de una transición energética justa en el Perú, liderada por el Ministerio de Energía y Minas (MINEM). Esta propuesta es el resultado de un análisis de: (i) el marco legal y regulatorio, (ii) los estudios realizados en la materia por parte de organismos multilaterales, y (iii) las iniciativas de transición propuestas por el sector privado; a traves de la cual busca impulsar una propuesta formal de política pública de transición energética justa denominada Agenda de Transición Energética para el Perú.
Soledad, ansiedad, depresión y adopción del rol del cuidador de personas con enfermedad crónica en San Gil, Colombia
Authors: Alonso-Rodríguez Martha Lucía , Chaparro-Díaz Lorena , Carreño-Moreno Sonia
Published: September 2023

Introducción: los cuidadores de personas con enfermedad crónica adoptan un nuevo rol que puede implicar respuestas como ansiedad, depresión y soledad. Objetivo: describir y correlacionar las variables de adopción del rol del cuidador, depresión, ansiedad y soledad en cuidadores familiares de personas con enfermedad crónica en la provincia de Guanentina, en San Gil, Santander (Colombia), durante el año 2021. Método: estudio descriptivo, analítico de corte transversal realizado con 112 cuidadores familiares de personas con enfermedades crónicas. Se utilizó una ficha de caracterización y los instrumentos: Escala adopción del rol del cuidador ROL, escala de soledad de UCLA (University of California at Los Ángeles) y Escala Hospitalaria de Ansiedad y Depresión HADS. Resultados: el perfil de los cuidadores fue predominantemente mujer; de 49 años en promedio; casadas, solteras o en unión libre; grado máximo de escolaridad bachiller; de ocupación hogar y nivel socioeconómico medio bajo y bajo. Se encontraron niveles altos de ansiedad en el 18,3 % de ellas, depresión en el 4,3 % y soledad en el 0,9 %, además, se evidenciaron niveles de adopción del rol del cuidador satisfactorios en el 100 %. Se encontró una correlación débil entre ansiedad, depresión y soledad y una correlación inversa entre estas variables con la adopción del rol del cuidador. De igual manera, se encontró una correlación directa entre la edad del paciente y los meses de diagnóstico con las horas de cuidado al día. Por último, se halló carácter predictivo de la ansiedad y la depresión sobre la adopción del rol, de la ansiedad y la adopción del rol sobre la depresión, y de la soledad y la depresión sobre la ansiedad. Conclusiones: los cuidadores tenían niveles de ansiedad, depresión y soledad normales que, al correlacionarse entre sí y con la adopción del rol del cuidador, validan la idea de que, si se interviene a los cuidadores en su trayectoria con orientaciones sobre su rol en cuanto a las labores, la organización y las respuestas se puede contribuir en la disminución de la ansiedad, depresión y soledad. Discusión: la correlación directa observada entre la soledad, depresión y ansiedad es coherente con lo reportado en estudios previos con cuidadores. Acorde con lo reportado por la literatura el desempeño satisfactorio del rol facilita los desenlaces en los cuidadores, en este caso, la moderación de la ansiedad, depresión y soledad.
Perspectivas metodológicas del análisis del discurso aplicadas al estudio de los sistemas de salud
Authors: Caballero-Rojas Helio , Mojica-Perilla Mónica
Published: September 2023

Introducción: el análisis del discurso es un abordaje alternativo de investigación de sistemas de salud. Objetivo: describir la producción científica que investiga los sistemas de salud utilizando el análisis del discurso como perspectiva teórico-metodológica. Métodos: revisión sistemática exploratoria de literatura, que incluyó la búsqueda de textos en inglés y español en cinco bases de datos (SciELO, MEDLINE, PubMed, EBSCO y ScienceDirect). Se utilizaron los descriptores “sistema OR salud” AND “análisis OR discurso” y sus traducciones al inglés. Se incluyeron artículos originales con metodología cualitativa, revisiones sistemáticas exploratorias de la literatura, ensayos y tesis doctorales, cuya metodología o tema de revisión fuese expresamente descrita como análisis de discurso de sistemas de salud, de sus funciones o estructura organizativa, publicados en el periodo entre enero de 1994 a diciembre de 2019; se excluyeron textos con metodología cuantitativa, estudios mixtos y metaanálisis. Resultados: se incluyó un total de 27 textos en la revisión, se describió en cuatro categorías la forma como el análisis del discurso puede ser utilizado en el estudio de los sistemas de salud: el concepto del proceso salud enfermedad, la autonomía del sujeto, los discursos de gestión y los sistemas de salud como política pública. Discusión: los sistemas de salud son campos para el ejercicio de las relaciones de poder que construyen sujetos, configuran la autonomía del sujeto y determinan las intervenciones del proceso salud-enfermedad. Conclusiones: esta revisión identificó que el discurso es utilizado como dispositivo de poder que configura sujetos y la forma como se interviene el proceso salud-enfermedad.
Impacto do treinamento das técnicas de ressuscitação cardiopulmonar em brigadistas de incêndios florestais
Authors: Dutra Pedro Rabelo , Maia Kleisson Antônio Pontes , Merlo Antonietta Saldanha Alves Bortolone , Campos Gabriel dos Santos , Oliveira Helcio Assis Rocha de , Nascimento Ohana Oliveira
Published: September 2023

As queimadas controladas e incêndios florestais de grande porte são maléficos ao ambiente e à saúde das pessoas. Durante um incêndio, podem ocorrer: intoxicação por fumaça, hipoxemia e, consequentemente, parada cardiorrespiratória (PCR). Estima-se que 300 mil indivíduos sofram PCR anualmente no Brasil, sendo que 30% dos casos correspondem a quadros fatais, geralmente devido à ausência de pessoas capacitadas para realizar o atendimento inicial à vítima. Membros das Brigadas de Combate Voluntário a Incêndios Florestais são um público ideal para inserir o conhecimento sobre o atendimento inicial à vítima de PCR, já que eles apresentam um maior risco de presenciar situações em que ela pode ocorrer. Trata-se de um estudo experimental e longitudinal em que foi ministrado um curso teórico-prático de Suporte Básico de Vida (SBV) aos membros das brigadas e aplicado questionários, pré e pós curso para avaliar a aprendizagem adquirida. Observou-se aumento da média de acertos no questionário (3,6 acertos para 7,0 acertos em 10 questões) e 91,7% apresentaram nota no questionário pós-curso maior que no pré-curso. Através do curso de SBV, observou-se ampliação dos conhecimentos relacionados ao tema pela população estudada, mas, por limitação do estudo, não foi possível avaliar a retenção do conhecimento a longo prazo. O conhecimento sobre SBV na população estudada foi, inicialmente, insuficiente para um atendimento inicial da PCR. Haja vista o contexto de ocorrência da PCR, os conhecimentos básicos sobre SBV deveriam ser mais ensinados ao público geral.
The Upregulation of miR-22 alleviates oxygen–glucose deprivation/reperfusion-induced injury by targeting Tiam1 in SH-SY5Y cells
Authors: Yin Jiansong , Wan Yu , Wang Jing , Xue Mei
Published: September 2023

MicroRNA-22 (miR-22) has been reported to exert a neuroprotective effect. However, the specific role and mechanism of miR-22 in ischemia/reperfusion (I/R)-induced brain injury are still not known well. In this study, we evaluated whether miR-22 participates in I/R-induced neuronal injury and the potential mechanism by using an oxygen-glucose deprivation/reperfusion (OGD/R) model in vitro. Our results showed that miR-22 was significantly down-regulated in SH-SY5Y cells suffering from OGD/R. Up-regulation of miR-22 by its specific mimic could protect SH-SY5Y cells against OGD/R-induced injury. The luciferase reporter assay demonstrated that T-cell lymphoma invasion and metastasis 1 (Tiam1) was a direct target of miR-22. MiR-22 mimic obviously inhibited Tiam1 expression in OGD/R-exposed SH-SY5Y cells. Tiam1 siRNA could attenuate OGD/R-induced SH-SY5Y cell injury. In addition, Tiam1 siRNA reduced the activation of Ras-related C3 botulinum toxin substrate 1 (Rac1) in OGD/R-exposed SH-SY5Y cells, and up-regulation of Rac1 activity could attenuate the neuroprotective effect of miR-22 up-regulation. Furthermore, OGD/R exposure led to increased methylation of miR-22, and the demethylating agent 5-Aza-dC significantly up-regulated miR-22 expression and inhibited Tiam1 expression and Rac1 activation. Taken together, our results demonstrated that DNA methylation-mediated miR-22 down-regulation aggravated I/R-induced neuron injury by promoting the activation of Tiam1/Rac1 signals. Our findings provide a deeper understanding of I/R-induced brain injury and suggest that miR-22 may be a promising therapeutic target for this disease.
Bionics investigation of blood 25-hydroxyvitamin D in the interpretable biomechanics diagnosis of childhood anemia
Authors: Zhang Lechi , Huang Aijie , Cai Jingye , Hou Jiangting , Deng Hongyan , Liu Chenxiao
Published: September 2023

Vitamin D deficiency (VDD) causes a wide range of health problems, including anemia in infants. If not treated promptly, it may create serious issues for infants with long-term impacts. Therefore, a satisfactory solution to this problem is required. This investigation was to explore the correlation between the blood 25-hydroxyvitamin D (25(OH)D) levels and childhood anemia. In this investigation, a cross-sectional examination was performed on 2,942 babies ranging in age from 2 to 36 months and classified into three cohorts: VDD (Vitamin D deficiency), VDI (Vitamin D insufficiency), and VDS (Vitamin D sufficiency). Multiple-variables and multinomially-related logistic regressions for examining the anemia status-vitamin D (Vit-D) relationship of the baseline as the interpretable visual quality models were examined. The median serum 25(OH)D level in 2,942 infants was 24.72±4.26 ng/l, with 661 cases (22.5%) of VDD and 1710 cases of deficiency (58.1%), and a noticeable seasonal variation (p<0.05). Anemia was present in 28.5% of the VDD group compared with 3.3% in vit-D sufficient infants (p<0.0001). Lower levels of 25(OH)D were found to be associated with an increased risk of anemia in a multiple-variable regression analysis. In healthy children, low 25(OH)D levels were associated with increased risk of anemia. Biologically inspired, primary care physicians should assess Vit-D levels and place a greater emphasis on adequate supplementation for deficiency prevention.
CRISPR-Cas9 guided rna based model for the treatment of Amyotrophic Lateral Sclerosis: A progressive neurodegenerative disorder
Authors: Naveed Muhammad , Aqib Shabbir Muhammad , Aziz Tariq , Hurraira Hafiz Muhammad , Fatima Zaidi Sayyeda , Athar Ramsha , Chattha Hassan Anwer , Alharbi Metab , Alshammari Abdulrahman , Alasmari Abdullah F.
Published: September 2023

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder that leads to the degeneration of motor neurons and the weakening of muscles. Despite extensive research efforts, there is currently no cure for ALS and existing treatments only address its symptoms. To address this unmet medical need, genome editing technologies, such as CRISPR-Cas9, have emerged as a promising solution for the development of new treatments for ALS. Studies have shown that CRISPR-Cas9-guided RNAs have the potential to provide accurate and effective silencing in the genetic disease of ALS. Results have demonstrated a 67% on-target score and a 98% off-target score with GC content within the range of 40–60%. This is further validated by the correlation between the gRNA’s structural accuracy and the minimum free energy. The use of CRISPR-Cas9 provides a unique opportunity to target this disease at the molecular level, offering hope for the development of a more effective treatment. In silico and computational therapeutic approaches for ALS suggest that the CRISPR-Cas9 protein holds promise as a future treatment candidate. The CRISPR mechanism and the specificity of gRNA provide a novel therapeutic approach for this genetic disease, offering new hope to those affected by ALS. This study highlights the potential of CRISPR-Cas9 as a promising solution for the development of new treatments for ALS. Further research is required to validate these findings in preclinical and clinical trials and to establish the safety and efficacy of this approach in the treatment of ALS.
Анализ и разработка шихты для брикетирования стружки шарикоподшипниковой стали ШХ15
Authors: Юшин В.В. , Тимофеев Г.П , Костин Н.Н , Костин Н.А
Published: September 2023

Проведено исследование металлошихты на основе стружки шарикоподшипниковой стали ШХ 15, шлама электросталеплавильных печей с содержанием оксида железа Fe2O3 - 70%, торфа. Предложен состав шихты и технология брикетирования, позволяющая получать брикеты с высокими качественными характеристиками, механической прочностью и физикохимической устойчивостью брикетов, снизить их себестоимость и расширить сырьевую базу. Экспериментально показана высокая эффективность предложенного технологического процесса методом холодного брикетирования со связующими компонентами, как наиболее приемлемого способа окускования металлической стружки с целью ее утилизации. По результатам проведённых исследований можно заключить, что создание энергосберегающих технологий позволяет более рационально использовать отходы производства и вовлекать их в технологический цикл получения новых материалов с меньшими затратами
Исследование вопросов древнего познания с помощью информационных технологий
Authors: Полякова О.О
Published: September 2023

Современные информационные технологии, например, в виде астрономических программ, помогают очутиться в любой эпохе и в любой точке земного шара, помогая ощутить современному исследователю возможности познания древними людьми окружающего мира в соответствии с теорией постнеклассической философии о создании саморазвивающихся систем познания в зависимости от места и времени восприятия окружающей действительности (по Степину и Дубровскому). Применение информационных технологий может помочь пролить свет на некоторые «белые пятна» теории познания и культуры. В статье приведены несколько примеров практического исследования с помощью информационных технологий в вопросах теории познания в зависимости от времени и места возможного осознания древними людьми окружающей действительности.
Nature-convergent Principles and Rational Use of Resources in Water Treatment and Processing
Authors: Sokolov L.I. , Silinksy V.A. , Sokolov K.L.
Published: September 2023

New ways justified to improve technological nature-convergent principles and schemes for the rational use of resources in water treatment and processing. Main principles for the rational use of resources, nature-convergency and ressources substitution were developped. The impact of ultrasound on the production of highly reactive sodium hypochlorite was revealed. The know-how of an active chlorine-containing reagent from underground mineral waters was studied and its effectiveness in disinfecting natural and waste waters of pulp and paper and fish processing industries was proven. A new formula for fertile soil production based on tap water sediment was developed.
Fibreglass Catalysts for the Removal of Nitrogen Oxides from Industrial Exhaust Gases
Authors: Golyashova K.E. , Elyshev A.V. , Lopatin S.A. , Zagoruyko A.N.
Published: September 2023

A method for removing nitrogen oxides from industrial of exhaust gases by catalytic reduction using fibreglass carriers was studied. It was noted that this know-how reduces nitrogen oxides and oxidizes carbon monoxide and hydrocarbons to safe compounds at moderate temperatures without additional reagents (ammonia, urea). It was proven that catalytic blocks structured with corrugated flat metal meshes provide the highest catalyst activity, and the best carrier is macosatin fabric. It was concluded that the described catalysts are characterized by high internal mass exchange rate in combination with low hydraulic resistance, high permeability, and the possibility of being used in dusty flows, which makes them very promising for treating various flue and exhaust gases.
Analysis of the Portfolio of Industrial Waste Resources in the Production of Cement-free Hardening Mixtures for Open-cut Flushing of Workings
Authors: Potokina M.V. , Strekalova T.A. , Veretnova T.A. , Balanev R.O. , Budnik E.V.
Published: September 2023

Analysis of the studies results of the resource portfolio and the main characteristics of by-products with the possibility of their use as inert aggregates of cement-free hardening mixtures, which, together with the development and improvement of the coal mining process scheme, allows addressing environmental issues. It was revealed that, during the reclamation of open-cut mining, retainers can be made by a cement-free layer of hardening backfill from preconditionned technogenic products, which, after hardening, becomes a fixative and prevents soil subsidence.
Urgent APIP in the Implementation of Bureaucracy Innovation to Establish quality of Maintenance Free of Corruption, Collusion, and Nepotism
Authors: Nopirina Nopirina
Published: September 2023

In order to realize bureaucratic innovation, APIP has the role of internal supervision to encourage the creation of a government system with high integrity. The formulation of the problem in this research is (1) what is the role of APIP in carrying out more accountable supervision to Realize the Quality of Good, Clean, Corruption, Collusion, and Nepotism. (2) what are the Inhibiting Factors of APIP in Conducting Supervision to Ensure that Bureaucratic Reforms Can Be Realized and avoid the abuse of authority, the practice of KKN. The method used in this research is qualitative descriptive. The results of this research are: The role of APIP as stated in the Regulation of the Minister of Empowerment of State Apparatus and Bureaucratic Reform is strengthened again by Government Regulation Number 60 of 2008 regarding the Internal Control System of Government Agencies (SPIP) article 48 which states that the Government's Internal Supervision Apparatus conducts internal supervision through, audit, review, evaluation, monitoring and other surveillance activities. In the realization of its implementation, the supervision function performed by APIP until now is carried out through the role of inspection (watchdog), the role of consultant (consultant) and the role of catalyst and management assistance (catalyst). Systemic Challenges in the Quantity and Quality of Human Resources, Budgets, and Institutions and Authority, Issues of Independence, Competence, and Integrity of Human Resources APIP That All This Time Is Still Considered "Far from the Fire". An indication of the weakness of said independence can be seen from the position of APIP's human resources which structurally is still under the control of the leaders of government agencies. Therefore, such conditions do not allow APIP's human resources to carry out supervision professionally and objectively. From the commitment of budget allocation, legally, there is no legal basis for government agencies to allocate the budget in a certain amount or percentage in the framework to support the implementation of the supervision function carried out by the inspectorate.
The Effect of Self Congruity and Brand Personality on Brand Loyalty
Authors: Siswandi Rizky Annisa , Iriani Sri Setyo , Artanti Yessy
Published: September 2023

Adventure has become a popular means of entertainment in Indonesian society, and there has even been a lifestyle trend among millennials, such as exploring the forest, exploring nature on motorbikes, camping, along rivers, climbing mountains, exploring beaches, and visiting various other natural attractions. also supported by geographical conditions and natural wealth that attract travelers and adventurers. This phenomenon creates business opportunities because these activities require adequate facilities and equipment. However, because business competition is getting higher, it is even more difficult to retain consumers. Brand development is very influential for all types of products that are consumer needs, especially equipment and needs for outdoor activities, because often brands are associated with human personality traits. The purpose of this study was to examine and analyze the effect of Brand Personality and Self Congruity variables on brand loyalty of adventure products from Indonesian brands Eiger, Consina, Avtech, Kalibre. The analytical method used is multiple linear regression using the SPSS (Statistical Product and Service Solution) application tool. The test results show that the Brand Personality variable with a regression coefficient of 0.404 and a significance of 0.001 <0.005 has a positive and significant effect on the Brand Loyalty variable, while the Self Congruity variable with a regression coefficient value of 0.080 and a significance of 0.508 > 0.05 does not significantly affect the Brand Loyalty variable. The purpose of this study was to examine and analyze the effect of Brand Personality and Self Congruity variables on brand loyalty of adventure products from Indonesian brands Eiger, Consina, Avtech, Kalibre. The analytical method used is multiple linear regression using the SPSS (Statistical Product and Service Solution) application tool. The test results show that the Brand Personality variable with a regression coefficient of 0.404 and a significance of 0.001 <0.005 has a positive and significant effect on the Brand Loyalty variable, while the Self Congruity variable with a regression coefficient value of 0.080 and a significance of 0.508 > 0.05 does not significantly affect the Brand Loyalty variable. The purpose of this study was to examine and analyze the effect of Brand Personality and Self Congruity variables on brand loyalty of adventure products from Indonesian brands Eiger, Consina, Avtech, Kalibre. The analytical method used is multiple linear regression using the SPSS (Statistical Product and Service Solution) application tool. The test results show that the Brand Personality variable with a regression coefficient of 0.404 and a significance of 0.001 <0.005 has a positive and significant effect on the Brand Loyalty variable, while the Self Congruity variable with a regression coefficient value of 0.080 and a significance of 0.508 > 0.05 does not significantly affect the Brand Loyalty variable.
COVID 19 Pandemic: Religious Leadership and the Challenges of Good Governance in Nigeria
Authors: Udeagha Nduka , Nwamah Grace Ozioma
Published: September 2023

The paper focuses on the effects of SARS-CoV-2, COVID-19 in Nigeria as relates to issues of religion and the challenges of good governance. The recent outbreak of SARS-CoV-2 in most countries of the world, which culminated in governments across the globe, instituting measures of lockdown as a means of containing the spread of the virus, appears to be a perceptible assessment for the religious institutions to re-evaluate their allegiance and commitment to good governance in Nigeria. The paper is a qualitative assessment of the issues of religious beliefs and the challenges of good governance in Nigeria as undergirded by the outbreak of coronavirus pandemic. The COVID-19 pandemic, which resulted in social distancing and banning of congregational religious activities in most countries of the world, was seen as a threat to religious activities by some religious groups and leadership in Nigeria. This notion consequently led to various utterances and actions that challenged the responsive efforts of government in containing the virus. The paper argues that such conducts are inimical to state public health measures and good governance in Nigeria. It, therefore, surmises that religious groups, particularly their leaders, need to discontinue from complicating an already challenged political leadership of the country, rather they should endeavour to use their enormous influence and contribute towards good governance by controlling faith-based emotions, synergizing and assisting the government, especially in such difficult time in history as presented by the pandemic. If religious sentiments are significantly controlled, democratic governance in Nigeria will fare better.
Enhanced Microfluidics Mixing Performance in a Grooved Serpentine Microchannel at Different Flow Rates
Authors: AKSOY Faruk , YESILOZ Gurkan
Published: September 2023

Reliable and efficient mixing in microfluidic systems is crucial for various applications such as molecular diagnostics, DNA hybridization, microreactors and nanoparticle synthesis. However, achieving adequate mixing at the microscale is challenging due to the fact that flow regime in microfluidics is laminar that is characterized by low Reynolds numbers. In an attempt to tackle this challenge, active and passive strategies have been utilized to enhance mixing. Passive techniques mainly rely on the interaction between fluid and channel geometry in order to extend the interface between the components of the fluid by inducing transversal flows. Passive methods have shown their simplicity over the active methods in microfluidics by simply controlling the channel geometry and flow configurations without involving any complex external forces and components. Based on this, our work presents a passive micromixer design with trapezoidal grooves placed at the bottom of the serpentine channels. The grooves induce periodic pressure drops along the channel which create staggered transversal vortices in orthogonal directions which disturbs the symmetries in the flow that results in stirring. These combined effects result in an enhanced mixing performance especially at higher flow rates. The results suggest that the design could be integrated into lab-on-a-chip systems to achieve enhanced mixing of biological or chemical components with reduced footprint, complexity and cost.
Tourism digitalization paradox
Authors:   Saratov State University, Cherevichko Tatiana V. , Temyakova Tatiana V. ,   Saratov State University
Published: September 2023

Introduction. The article substantiates the relevance of domestic tourism development, examines the domestic tourist flow dynamics, and pays attention to the importance of mass tourism development for Russian economy. Theoretical analysis. Institutionalization and digitalization are fundamental elements of the mass domestic sustainable tourism development matrix. It is noted that a direct appeal to the tourist services producers by potential tourists through digital institutions becomes a condition for mass tourism restoration of in our country. Empirical analysis. An important role in domestic tourism development is played by the creation of digital products, which include a mobile application-designer of tourist trips “Be your own tour operator”. The paper gives an example of building a tourist route in Samara, proves the advantages of using the services of the proposed application. Results. The formation of mass domestic sustainable tourism requires the production of a customized tourist product, which can be achieved by applying institutional and digital mechanisms to the tourism industry. The customization of the tourist product reduces the role of tour operators in the domestic market and increases the role of tour guides and other direct producers of tourist services, which is the tourism digitalization paradox.
Cerrahlarda fiziksel iş yükünün servikal sagittal dengeye etkisi
Authors: CÖMERT Serhat , HOROZ Levent
Published: September 2023

Amaç: Cerrahlar, işle ilgili kas-iskelet sistemi bozuklukları da dahil olmak üzere çeşitli mesleki risklere maruz kalmaktadır. Cerrahlarda tekrarlayan hareketler ve uzun süreli uygunsuz duruş gibi mesleki gereklilikler sonucu boyun ağrıları görülebilmektedir. Boyun ağrıları nedenleri arasında servikal sagittal denge parametrelerinin önemli bir yeri vardır. Bu çalışmada cerrahların servikal sagittal denge parametrelerinin değerlendirilmesi amaçlanmıştır.

Gereç ve Yöntemler: Bu kesitsel çalışmaya 2016-2019 yılları arasında işle ilgili boyun ağrısı olan 57 hasta dahil edildi. Manyetik rezonans görüntüleme kullanılarak T1S ve Cobb açısı ölçüldü. Katılımcıların yaş, vücut kitle indeksi, boy, kilo gibi kişisel özellikleri başvuru sırasında doldurulan anket ile elde edildi.

Bulgular: Çalışmaya elli yedi katılımcı dahil edildi. Bunların 13'ü beyin cerrahı, 13'ü kulak burun boğaz cerrahı, 12'si genel cerrah, 11'i plastik cerrah ve 8'i kalp ve damar cerrahıydı. Cerrahların ortalama yaşı 38,7 ± 6,44 yıl ve ortalama VAS'ı 5,12± 0,73 idi. Ortalama T1S 23,2° ± 7,95° ve ortalama Cobb açısı 12,3° ± 7,99° idi. Beyin cerrahlarında ortalama T1S 22,2° ± 11,18° ve ortalama Cobb açısı 8,4° ± 5,91° idi. Tüm cerrahi branşlar içinde hem T1 hem de cobb açısı ölçümlerinde beyin ve sinir cerrahları en düşük ortalamaya sahipti.

Sonuç: Cerrahların günlük rutin iş yükü, servikal sagittal dengenin bozulmasına neden olmakta, bu da cerrahların mesleki kas-iskelet sistemi hastalıkları açısından yüksek risk grubunda olduğunu düşündürmektedir.