bluuebunny/crossref_metadata_2025 huggingface dataset:
Vascular TOS—Creating a Protocol and Sticking to It
Authors: Archie Meena , Rigberg David
Published: June 2017

Thoracic Outlet Syndrome (TOS) describes a set of disorders that arise from compression of the neurovascular structures that exit the thorax and enter the upper extremity. This can present as one of three subtypes: neurogenic, venous, or arterial. The objective of this section is to outline our current practice at a single, high-volume institution for venous and arterial TOS. VTOS: Patients who present within two weeks of acute deep vein thrombosis (DVT) are treated with anticoagulation, venography, and thrombolysis. Those who present later are treated with a transaxillary first rib resection, then a two-week post-operative venoplasty. All patients are anticoagulated for 2 weeks after the post-operative venogram. Those with recurrent thrombosis or residual subclavian vein stenosis undergo repeat thrombolysis or venoplasty, respectively. ATOS: In patients with acute limb ischemia, we proceed with thrombolysis or open thrombectomy if there is evidence of prolonged ischemia. We then perform a staged transaxillary first rib resection followed by reconstruction of the subclavian artery. Patients who present with claudication undergo routine arterial duplex and CT angiogram to determine the pathology of the subclavian artery. They then undergo decompression and subclavian artery repair in a similar staged manner.
Dynamic Contrast-Enhanced Ultrasound of Colorectal Liver Metastases as an Imaging Modality for Early Response Prediction to Chemotherapy
Authors: Mogensen Marie , Hansen Martin , Henriksen Birthe , Axelsen Thomas , Vainer Ben , Osterlind Kell , Nielsen Michael
Published: June 2017

Our aim was to investigate whether dynamic contrast-enhanced ultrasound (DCE-US) can detect early changes in perfusion of colorectal liver metastases after initiation of chemotherapy. Newly diagnosed patients with colorectal cancer with liver metastases were enrolled in this explorative prospective study. Patients were treated with capecitabine or 5-fluorouracil-based chemotherapy with or without bevacizumab. DCE-US was performed before therapy (baseline) and again 10 days after initiation of treatment. Change in contrast-enhancement in one liver metastasis (indicator lesion) was measured. Treatment response was evaluated with a computed tomography (CT) scan after three cycles of treatment and the initially observed DCE-US change of the indicator lesion was related to the observed CT response. Eighteen patients were included. Six did not complete three series of chemotherapy and the evaluation CT scan, leaving twelve patients for analysis. Early changes in perfusion parameters using DCE-US did not correlate well with subsequent CT changes. A subgroup analysis of eight patients receiving bevacizumab, however, demonstrated a statistically significant correlation (p = 0.045) between early changes in perfusion measures of peak enhancement at DCE-US and tumor shrinkage at CT scan. The study indicates that early changes in DCE-US perfusion measures may predict subsequent treatment response of colorectal liver metastases in patients receiving bevacizumab.
Information Geometry of Non-Equilibrium Processes in a Bistable System with a Cubic Damping
Authors: Hollerbach Rainer , Kim Eun-jin
Published: June 2017

A probabilistic description is essential for understanding the dynamics of stochastic systems far from equilibrium, given uncertainty inherent in the systems. To compare different Probability Density Functions (PDFs), it is extremely useful to quantify the difference among different PDFs by assigning an appropriate metric to probability such that the distance increases with the difference between the two PDFs. This metric structure then provides a key link between stochastic systems and information geometry. For a non-equilibrium process, we define an infinitesimal distance at any time by comparing two PDFs at times infinitesimally apart and sum these distances in time. The total distance along the trajectory of the system quantifies the total number of different states that the system undergoes in time and is called the information length. By using this concept, we investigate the information geometry of non-equilibrium processes involved in disorder-order transitions between the critical and subcritical states in a bistable system. Specifically, we compute time-dependent PDFs, information length, the rate of change in information length, entropy change and Fisher information in disorder-to-order and order-to-disorder transitions and discuss similarities and disparities between the two transitions. In particular, we show that the total information length in order-to-disorder transition is much larger than that in disorder-to-order transition and elucidate the link to the drastically different evolution of entropy in both transitions. We also provide the comparison of the results with those in the case of the transition between the subcritical and supercritical states and discuss implications for fitness.
Determining Switched Reluctance Motor Current Waveforms Exploiting the Transformation from the Time to the Position Domain
Authors: Bernat Jakub , Stępień Sławomir , Sykulski Jan K.
Published: June 2017

This paper addresses the issue of estimating current waveforms in a switched reluctance motor required to achieve a desired electromagnetic torque. The methodology employed exploits the recently-developed method based on the transformation from the time to the position domain. This transformation takes account of nonlinearities caused by a doubly-salient structure. Owing to this new modelling technique it is possible to solve optimization problems with reference torque, constrained voltage, and parameter sensitivity accounted for. The proposed methodology is verified against published solutions and illustrated through simulations and experiments.
The Influence of Small-Scale Power Plant Supporting Schemes on the Public Trader and Consumers
Authors: Varfolomejeva Renata , Sauhats Antans , Sokolovs Nikita , Coban Hasan
Published: June 2017

The mechanism of support schemes for achieving the required share of renewable energy sources (RES) was implemented into the energy sector. The issued amount of support requires state subsidies. The end-users of electricity are paying the mandatory procurement component taxes to cover these subsidies. The article examines the way of minimizing the influence of the existing RES supporting schemes on the consumers. The fixed purchased electricity price in the case of RES does not encourage producers to operate at hours of peak consumption or when the price is high. Modification of the RES support mechanisms at the legislative level, firstly, could minimize the influence of the mandatory procurement component on the end-users’ electricity price, and secondly, could provide a great opportunity for the public trader to forecast the operation of small power plants and their generation abilities. Numerical experiments with models of two types of power plants (biofuel and hydropower) prove the existence of a problem and the presence of a solution. This problem constitutes the main subject of the present paper.
Elevated Blood Lead Levels in Children Associated with Living near Mining Waste Sites in Guerrero/Mexico
Authors: Soto-Ríos María , Juárez-Pérez Cuauhtémoc , Rendón-Gandarilla Francisco , Talavera-Mendoza Oscar , Aguilar-Madrid Guadalupe
Published: June 2017

Blood lead levels (BLL) in children are associated with lead in soil and represent a major public health problem; however, there are few reports of lead contamination related to mining waste sites in Mexico. Therefore, we conducted a cross-sectional study in the State of Guerrero to identify the association between proximity of residence to mining site waste and BLL in children. The impact of the different variables related to BLL were analyzed with logistic regression. Geometric mean BLL was 13.6 μg/dL, 15.9 μg/dL in communities proximal to waste sites and 5.5 μg/dL in a distant control community. Children living in communities near the mining waste have higher BLL that children living in communities far away from the waste. Our results are similar to studies in other countries and indicate that mining waste sites remain an active source of BLL contamination that affect children’s health.
Influence of Food Characteristics and Food Additives on the Antimicrobial Effect of Garlic and Oregano Essential Oils
Authors: García-Díez Juan , Alheiro Joana , Pinto Ana Luisa , Soares Luciana , Falco Virgilio , Fraqueza Maria João , Patarata Luis
Published: June 2017

Utilization of essential oils (EOs) as antimicrobial agents against foodborne disease has gained importance, for their use as natural preservatives. Since potential interactions between EOs and food characteristics may affect their antimicrobial properties, the present work studies the influence of fat, protein, pH, aw and food additives on the antimicrobial effect of oregano and garlic EOs against Salmonella spp. and Listeria monocytogenes. Results showed that protein, pH, aw, presence of beef extract, sodium lactate and nitrates did not influence their antimicrobial effect. In contrast, the presence of pork fat had a negative effect against both EOs associated with their dilution of the lipid content. The addition of food phosphates also exerts a negative effect against EOs probably associated with their emulsification properties as observed with the addition of fat. The results may help the food industry to select more appropriate challenges to guarantee the food safety of foodstuffs.
Socialization in the Neoliberal Academy of STEM Scholars: A Case Study of Negotiating Dispositions in an International Graduate Student in Entomology
Authors: Rabbi Shakil , Canagarajah A.
Published: June 2017

This article examines how neoliberal orders of discourse shape the dispositions to academic literacies of an international graduate student in entomology. As this ideology of market logic consolidates its hegemony in universities of excellence and US culture at large, academic socialization and disciplinary activities increasingly aim to create scholarly dispositions and subjectivities that align with it. Such processes are further complicated by the backgrounds of international graduate students—an ever-larger proportion of graduate students in STEM who often hail from educational cultures significantly different from the U.S. Our analysis of an international graduate student’s literacy practices in terms of motivations and outcomes shows that his literacies echo the dispositions pushed by neoliberal ideologies, but are not over-determined by them. Rather, as our case study illustrates, his socialization is a layered process, with ambiguous implications and strategic calculations making up literacies and disciplinary outcomes. We believe closely mapping such tensions in literacies and socialization processes increases humanities scholars’ awareness both of the potential contradictions of educating international graduate students into the neoliberal model and of how the university can still be used to develop the dispositions needed to renegotiate the neoliberal order of discourse for more ethical and empowering purposes.
Solidification and Biotoxicity Assessment of Thermally Treated Municipal Solid Waste Incineration (MSWI) Fly Ash
Authors: Gong Bing , Deng Yi , Yang Yuanyi , Tan Swee , Liu Qianni , Yang Weizhong
Published: June 2017

In the present work, thermal treatment was used to stabilize municipal solid waste incineration (MSWI) fly ash, which was considered hazardous waste. Toxicity characteristic leaching procedure (TCLP) results indicated that, after the thermal process, the leaching concentrations of Pb, Cu, and Zn decreased from 8.08 to 0.16 mg/L, 0.12 to 0.017 mg/L and 0.39 to 0.1 mg/L, respectively, which well met the limits in GB5085.3-2007 and GB16689-2008. Thermal treatment showed a negative effect on the leachability of Cr with concentrations increasing from 0.1 to 1.28 mg/L; nevertheless, it was still under the limitations. XRD analysis suggested that, after thermal treatments, CaO was newly generated. CaO was a main contribution to higher Cr leaching concentrations owing to the formation of Cr (VI)—compounds such as CaCrO4. SEM/EDS tests revealed that particle adhesion, agglomeration, and grain growth happened during the thermal process and thus diminished the leachability of Pb, Cu, and Zn, but these processes had no significant influence on the leaching of Cr. A microbial assay demonstrated that all thermally treated samples yet possessed strong bactericidal activity according to optical density (OD) test results. Among all samples, the OD value of raw fly ash (RFA) was lowest followed by FA700-10, FA900-10, and FA1100-10 in an increasing order, which indicated that the sequence of the biotoxicity for these samples was RFA > FA700-10 > FA900-10 > FA1100-10. This preliminary study indicated that, apart from TCLP criteria, the biotoxicity assessment was indispensable for evaluating the effect of thermal treatment for MSWI fly ash.
Prevalence and Risk Factors of Low Health Literacy: A Community-Based Study in Shanghai, China
Authors: Wu Ying , Wang Lu , Cai Zhongyuan , Bao Luqi , Ai Pu , Ai Zisheng
Published: June 2017

Background: Health literacy is an increasingly important public health concern. However, little is known about the health literacy of general public in China. The aim of this study was to evaluate the prevalence of low health literacy and demographic associations in Shanghai, China. Methods: This study was a community-based cross-sectional health survey utilizing a multi-stage random sampling design. The sample consisted of 1360 individuals aged 15–69 years with the total community-dwelling Chinese as the sample frame. Health literacy was measured by a questionnaire developed on the basis of a national health literacy manual released by the Chinese Ministry of Health. Multiple logistic regression models were used to identify whether common socio-demographic features were associated with health literacy level. Results: The prevalence of low health literacy was 84.49% (95% CI, 82.56% to 86.41%). The prevalence of low health literacy was negatively associated with the level of education, occupation, and annual household income, but was not associated with gender, age, or the presence of non-communicable chronic disease. Conclusions: Simplifying health services, enhancing health education, and promoting interventions to improve health literacy in high-risk populations should be considered as part of the strategies in the making of health policy in China.
Legume Lectins: Proteins with Diverse Applications
Authors: Lagarda-Diaz Irlanda , Guzman-Partida Ana , Vazquez-Moreno Luz
Published: June 2017

Lectins are a diverse class of proteins distributed extensively in nature. Among these proteins; legume lectins display a variety of interesting features including antimicrobial; insecticidal and antitumor activities. Because lectins recognize and bind to specific glycoconjugates present on the surface of cells and intracellular structures; they can serve as potential target molecules for developing practical applications in the fields of food; agriculture; health and pharmaceutical research. This review presents the current knowledge of the main structural characteristics of legume lectins and the relationship of structure to the exhibited specificities; provides an overview of their particular antimicrobial; insecticidal and antitumor biological activities and describes possible applications based on the pattern of recognized glyco-targets.
Lignin from Micro- to Nanosize: Production Methods
Authors: Beisl Stefan , Miltner Angela , Friedl Anton
Published: June 2017

Lignin is the second most abundant biopolymer after cellulose. It has long been obtained as a by-product of cellulose production in pulp and paper production, but had rather low added-value applications. A changing paper market and the emergence of biorefinery projects should generate vast amounts of lignin with the potential of value addition. Nanomaterials offer unique properties and the preparation of lignin nanoparticles and other nanostructures has therefore gained interest as a promising technique to obtain value-added lignin products. Due to lignin’s high structural and chemical heterogeneity, methods must be adapted to these different types. This review focuses on the ability of different formation methods to cope with the huge variety of lignin types and points out which particle characteristics can be achieved by which method. The current research’s main focus is on pH and solvent-shifting methods where the latter can yield solid and hollow particles. Solvent shifting also showed the capability to cope with different lignin types and solvents and antisolvents, respectively. However, process conditions have to be adapted to every type of lignin and reduction of solvent demand or the integration in a biorefinery process chain must be focused.
Transcriptional Responses in the Murine Spleen after Toxoplasma gondii Infection: Inflammasome and Mucus-Associated Genes
Authors: Znalesniak Eva , Fu Ting , Salm Franz , Händel Ulrike , Hoffmann Werner
Published: June 2017

The spleen plays an important role in coordinating both adaptive and innate immune responses. Here, the transcriptional response to T. gondii infection in the murine spleen was characterized concerning inflammasome sensors (two different models: seven days after oral or four weeks after intraperitoneal infection). Additionally, Tff1KO and Tff3KO mice were investigated because TFF genes are often upregulated during inflammation. The expression of the pattern-recognition receptors Nlrp3, Nlrp12, and Nlrp1a was significantly increased after infection. This increase was diminished in Tff1KO and Tff3KO mice pointing towards a positive regulation of the inflammatory response by Tff1 and Tff3. Furthermore, the transcription of Tff1 (encoding a motogenic lectin) and other secretory genes was analyzed, i.e., gastrokines (Gkn), IgG Fc binding protein (Fcgbp), and the mucin Muc2. The corresponding gene products belong to an interactome protecting mucous epithelia. Tff1 was significantly induced after infection, which might increase the motility of immune cells. In contrast, Gkn3, Fcgbp, and Muc2 were downregulated seven days after oral infection; whereas four weeks after i.p. infection only Gkn3 remained downregulated. This might be an indication that Gkn3, Fcgbp, and Muc2 are involved in the transient disruption of the splenic architecture and its reorganization, which is characteristic after T. gondii infection.
Personalized Medicine: New Perspectives for the Diagnosis and the Treatment of Renal Diseases
Authors: Gluba-Brzózka Anna , Franczyk Beata , Olszewski Robert , Banach Maciej , Rysz Jacek
Published: June 2017

The prevalence of renal diseases is rising and reaching 5–15% of the adult population. Renal damage is associated with disturbances of body homeostasis and the loss of equilibrium between exogenous and endogenous elements including drugs and metabolites. Studies indicate that renal diseases are influenced not only by environmental but also by genetic factors. In some cases the disease is caused by mutation in a single gene and at that time severity depends on the presence of one or two mutated alleles. In other cases, renal disease is associated with the presence of alteration within a gene or genes, but environmental factors are also necessary for the development of disease. Therefore, it seems that the analysis of genetic aspects should be a natural component of clinical and experimental studies. The goal of personalized medicine is to determine the right drug, for the right patient, at the right time. Whole-genome examinations may help to change the approach to the disease and the patient resulting in the creation of “personalized medicine” with new diagnostic and treatment strategies designed on the basis of genetic background of each individual. The identification of high-risk patients in pharmacogenomics analyses will help to avoid many unwarranted side effects while optimizing treatment efficacy for individual patients. Personalized therapies for kidney diseases are still at the preliminary stage mainly due to high costs of such analyses and the complex nature of human genome. This review will focus on several areas of interest: renal disease pathogenesis, diagnosis, treatment, rate of progression and the prediction of prognosis.
Emerging Role of the Spleen in the Pharmacokinetics of Monoclonal Antibodies, Nanoparticles and Exosomes
Authors: Cataldi Mauro , Vigliotti Chiara , Mosca Teresa , Cammarota MariaRosaria , Capone Domenico
Published: June 2017

After being absorbed, drugs distribute in the body in part to reach target tissues, in part to be disposed in tissues where they do not exert clinically-relevant effects. Therapeutically-relevant effects are usually terminated by drug metabolism and/or elimination. The role that has been traditionally ascribed to the spleen in these fundamental pharmacokinetic processes was definitely marginal. However, due to its high blood flow and to the characteristics of its microcirculation, this organ would be expected to be significantly exposed to large, new generation drugs that can hardly penetrate in other tissues with tight endothelial barriers. In the present review, we examine the involvement of the spleen in the disposition of monoclonal antibodies, nanoparticles and exosomes and the possible implications for their therapeutic efficacy and toxicity. The data that we will review lead to the conclusion that a new role is emerging for the spleen in the pharmacokinetics of new generation drugs, hence suggesting that this small, neglected organ will certainly deserve stronger attention by pharmacologists in the future.
Eplerenone-Resistant Salt-Sensitive Hypertension in Nedd4-2 C2 KO Mice
Authors: Kino Tabito , Ishigami Tomoaki , Murata Tsumugi , Doi Hiroshi , Nakashima-Sasaki Rie , Chen Lin , Sugiyama Michiko , Azushima Kengo , Wakui Hiromichi , Minegishi Shintaro , Tamura Kouichi
Published: June 2017

The epithelial sodium channel (ENaC) plays critical roles in maintaining fluid and electrolyte homeostasis and is located in the aldosterone-sensitive distal nephron (ASDN). We previously found that Nedd4-2 C2 knockout (KO) mice showed salt-sensitive hypertension with paradoxically enhanced ENaC gene expression in ASDN under high oral salt intake. Eplerenone (EPL), a selective aldosterone blocker, is a promising therapeutic option for resistant or/and salt-sensitive hypertension. We examined the effect of EPL on Nedd4-2 C2 KO mice with respect to blood pressure, metabolic parameters, and molecular level changes in ASDN under high oral salt intake. We found that EPL failed to reduce blood pressure in KO mice with high oral salt intake and upregulated ENaC expression in ASDN. Thus, salt-sensitive hypertension in Nedd4-2 C2 KO was EPL-resistant. Gene expression analyses of laser-captured specimens in ASDN suggested the presence of non-aldosterone-dependent activation of ENaC transcription in ASDN of Nedd4-2 C2 KO mice, which was abolished by amiloride treatment. Our results from Nedd4-2 C2 KO mice suggest that enhanced ENaC gene expression is critically involved in salt-sensitive hypertension under certain conditions of specific enzyme isoforms for their ubiquitination.
Association of miR-938G>A Polymorphisms with Primary Ovarian Insufficiency (POI)-Related Gene Expression
Authors: Cho Sung , Ahn Eun , An Hui , Kim Ji , Ko Jung , Kim Young , Lee Woo , Kim Nam
Published: June 2017

MicroRNAs (miRNAs) post-transcriptionally regulate gene expression in animals and plants. The aim of this study was to investigate whether polymorphisms in miR-938 are associated with the risk of primary ovarian insufficiency (POI) and POI-related target gene regulation. We identified the miR-938G>A polymorphisms within the seed sequence of mature miRNA and aligned the seed sequence with the 3′ untranslated region (UTR) of the gonadotropin-releasing hormone receptor (GnRHR) mRNA, a miR-938 target gene. We found that the binding of miR-938 to the 3′-UTR of GnRHR mRNA was significantly different between normal and variant alleles. Our data suggests that the dysregulation of miR-938G>A influences the binding to GnRHR and that miR-938G>A polymorphisms might contribute to regulation of POI-related target genes.
Wound-Healing Studies in Cornea and Skin: Parallels, Differences and Opportunities
Authors: Bukowiecki Anne , Hos Deniz , Cursiefen Claus , Eming Sabine
Published: June 2017

The cornea and the skin are both organs that provide the outer barrier of the body. Both tissues have developed intrinsic mechanisms that protect the organism from a wide range of external threats, but at the same time also enable rapid restoration of tissue integrity and organ-specific function. The easy accessibility makes the skin an attractive model system to study tissue damage and repair. Findings from skin research have contributed to unravelling novel fundamental principles in regenerative biology and the repair of other epithelial-mesenchymal tissues, such as the cornea. Following barrier disruption, the influx of inflammatory cells, myofibroblast differentiation, extracellular matrix synthesis and scar formation present parallel repair mechanisms in cornea and skin wound healing. Yet, capillary sprouting, while pivotal in proper skin wound healing, is a process that is rather associated with pathological repair of the cornea. Understanding the parallels and differences of the cellular and molecular networks that coordinate the wound healing response in skin and cornea are likely of mutual importance for both organs with regard to the development of regenerative therapies and understanding of the disease pathologies that affect epithelial-mesenchymal interactions. Here, we review the principal events in corneal wound healing and the mechanisms to restore corneal transparency and barrier function. We also refer to skin repair mechanisms and their potential implications for regenerative processes in the cornea.
Deconstructing Signaling Pathways in Cancer for Optimizing Cancer Combination Therapies
Authors: Yamaguchi Ryuji , Perkins Guy
Published: June 2017

A single cancer cell left behind after surgery and/or chemotherapy could cause a recurrence of cancer. It is our belief that the failure of chemotherapies is the failure to induce apoptosis in all cancer cells. Given the extraordinary heterogeneity of cancer, it is very difficult to eliminate all cancer cells with a single agent targeting a particular gene product. Furthermore, combinations of any two or three agents exhibiting some proven efficacy on a particular cancer type have not fared better, often compounding adverse effects without evidence of expected synergistic effects. Thus, it is imperative that a way be found to select candidates that when combined, will (1) synergize, making the combination therapy greater than the sum of its parts, and (2) target all the cancer cells in a patient. In this article, we discuss our experience and relation to current evidence in the cancer treatment literature in which, by deconstructing signaling networks, we have identified a lynchpin that connects the growth signals present in cancer with mitochondria-dependent apoptotic pathways. By targeting this lynchpin, we have added a key component to a combination therapy that sensitizes cancer cells for apoptosis.
Indifferent or Uninformed? Reflections of Health Professionals on Parental Education and Consent for Expanded Newborn Screening in Israel, 2008–2016
Authors: Zuckerman Shlomit
Published: June 2017

Background: This study explored the views of health professionals regarding parental education and informed consent for newborn screening (NBS) following the expansion of the NBS program in Israel. Methods: 24 in-depth interviews with 22 practitioners involved in NBS in Israel, and internationally, were conducted and analyzed qualitatively. Results and discussion: 1. Program creators, who were involved in the development, design, implementation, and delivery of the expanded NBS program, were concerned about the “indifferent” attitude of parents of newborns to NBS as opposed to their high awareness and utilization of prenatal screening. 2. Program creators evaluated program success by different standards of parental education and informed consent than did practitioners, who were involved solely or mostly in the delivery of NBS results. The latter were skeptical about the possibility of obtaining informed consent and expressed diverse views about desired levels of education and consent. Eight years later, parental indifference to NBS is still a major concern for program creators, but not for practitioners. Conclusions: Program creators, due to their role and direct responsibility, assess NBS as an independent, stand-alone process about which parents should be informed and educated. Therefore, they focus on the indifference of parents to NBS as a non-optimal achievement of one programmatic aspect. Practitioners, on the other hand, perceive the medical care of the newborn holistically, focusing on the overall well-being of the baby. Therefore, they would be satisfied if the best possible medical care is provided to the newborn, by screening, confirmatory diagnosis, and follow up, even if parents are less informed about the process.
[Bis(Trimethylsilyl)Methyl]Lithium and -Sodium: Solubility in Alkanes and Complexes with O- and N- Donor Ligands
Authors: Von Pilgrim Markus , Mondeshki Mihail , Klett Jan
Published: June 2017

In contrast to alkyl compounds of lithium, which play an important role in organometallic chemistry, the corresponding heavier alkali metal compounds are less investigated. These compounds are mostly insoluble in inert solvents or undergo solvolysis in coordinating solvents due to their high reactivity. An exception from this typical behavior is demonstrated by bis(trimethylsilyl)methylsodium. This study examines alkane solutions of bis(trimethylsilyl)methyllithium and -sodium by NMR spectroscopic and cryoscopic methods. In addition, structural studies by X-ray crystallography of the corresponding compounds coordinated by O- and N- ligands (tetrahydrofuran and tetramethylethylenediamine) present possible structural motifs of the uncoordinated compounds in solution.
Evaluating Human Balance Following an Exercise Intervention in Previously Sedentary, Overweight Adults
Authors: Morris Cody , Chander Harish , Garner John , DeBusk Hunter , Owens Scott , Valliant Melinda , Loftin Mark
Published: June 2017

Previous research suggests that an improvement in body composition could potentially lead to improvement in balance performance in previously overweight individuals. The purpose of this study was to evaluate if an exercise intervention without any specific balance training can lead to an improvement in standing balance. Fourteen overweight, but otherwise healthy adults (nine females, six males) (mean age: 23.5 years; mean height: 1.70 m, mean starting body mass: 94.1 kg) participated in this study. Balance performance was assessed with sensory organization test (SOT) and motor control test (MCT) on the NeuroCom® Equitest™, prior to and after a 10-week exercise intervention. Results revealed significant improvements in the following balance parameters following exercise intervention: eyes open, sway-referenced visual surrounding and platform condition (p = 0.033) for SOT equilibrium scores; SOT center of pressure (COP) sway in the eyes closed condition for anterior-posterior sway velocity (p = 0.006) and in the eyes open sway-referenced condition (p = 0.048). The results of the current study suggest that improved balance performance can result from an exercise intervention without any specific balance directed exercises, but that the results may be limited to the conditions where the somatosensory system plays a larger role in balance maintenance.
Detection of Land Subsidence in Kathmandu Valley, Nepal, Using DInSAR Technique
Authors: Bhattarai Richa , Alifu Haireti , Maitiniyazi Aikebaier , Kondoh Akihiko
Published: June 2017

Differential Synthetic Aperture Radar Interferometry (DInSAR) is a remote sensing technique that is capable of detecting land surface deformation with centimeter accuracy. In this research, this technique was applied to two pairs of Advanced Land Observing Satellite (ALOS) Phased Array L-band SAR (PALSAR) data to detect land subsidence in the Kathmandu valley from 2007 to 2010. The result revealed several subsidence areas towards the center of the valley ranging from a maximum of 9.9 km2 to a minimum of 1 km2 coverage with a maximum velocity of 4.8 cm/year, and a minimum velocity of 1.1 cm/year, respectively. The majority of the subsidence was observed in old settlement areas with mixed use development. The subsidence depth was found to gradually increase from the periphery towards the center in almost all detected subsidence areas. The subsidence depth was found to be in a range of 1 cm to 17 cm. It was found that the concentration of deep water extraction wells was higher in areas with higher subsidence rates. It was also found that the detected subsidence area was situated over geological formations mainly consisting of unconsolidated fine-grained sediments (silica, sand, silt, clay and silty sandy gravel), which is the major factor affecting the occurrence of land subsidence due to groundwater extraction.
Cryosphere and Psychrophiles: Insights into a Cold Origin of Life?
Authors: Feller Georges
Published: June 2017

Psychrophiles thrive permanently in the various cold environments on Earth. Their unsuspected ability to remain metabolically active in the most extreme low temperature conditions provides insights into a possible cold step in the origin of life. More specifically, metabolically active psychrophilic bacteria have been observed at −20 °C in the ice eutectic phase (i.e., the liquid veins between sea ice crystals). In the context of the RNA world hypothesis, this ice eutectic phase would have provided stability to the RNA molecules and confinement of the molecules in order to react and replicate. This aspect has been convincingly tested by laboratory experiments.
Friction Reduction Tested for a Downsized Diesel Engine with Low-Viscosity Lubricants Including a Novel Polyalkylene Glycol
Authors: Sander David , Knauder Christoph , Allmaier Hannes , Damjanović-Le Baleur Slavitsa , Mallet Philippe
Published: June 2017

With the increasing pressure to reduce emissions, friction reduction is always an up-to-date topic in the automotive industry. Among the various possibilities to reduce mechanical friction, the usage of a low-viscosity lubricant in the engine is one of the most effective and most economic options. Therefore, lubricants of continuously lower viscosity are being developed and offered on the market that promise to reduce engine friction while avoiding deleterious mixed lubrication and wear. In this work, a 1.6 L downsized Diesel engine is used on a highly accurate engine friction test-rig to determine the potential for friction reduction using low viscosity lubricants under realistic operating conditions including high engine loads. In particular, two hydrocarbon-based lubricants, 0W30 and 0W20, are investigated as well as a novel experimental lubricant, which is based on a polyalkylene glycol base stock. Total engine friction is measured for all three lubricants, which show a general 5% advantage for the 0W20 in comparison to the 0W30 lubricant. The polyalkylene glycol-based lubricant, however, shows strongly reduced friction losses, which are about 25% smaller than for the 0W20 lubricant. As the 0W20 and the polyalkylene glycol-based lubricant have the same HTHS-viscosity , the findings contradict the common understanding that the HTHS-viscosity is the dominant driver related to the friction losses.
Recovery of Silver Using Adsorption Gels Prepared from Microalgal Residue Immobilized with Functional Groups Containing Sulfur or Nitrogen
Authors: Khunathai Kanjana , Inoue Katsutoshi , Ohto Keisuke , Kawakita Hidetaka , Kurata Minoru , Atsumi Kinya , Fukuda Hiroaki , Alam Shafiq
Published: June 2017

Although biodiesel oil extracted from microalgae attracts much attention as one of the most promising green energies, its high production cost is a big problem, impeding its extensive use. In order to lower the production cost, the effective use of microalgal residue after extracting biofuel was investigated as a feed material of functional materials. In the present work, a new adsorbent for silver(I) was prepared by immobilizing functional groups of polyethylene-polyamine or dithiooxamide, which exhibita high affinity for soft Lewis acids such as silver(I) ions. Their adsorption behaviors for silver(I) were investigated from aqueous nitrate and acidothiourea media. The effects of the concentrations of nitrate and thiourea, as well as of sulfuric acid, were qualitatively interpreted. From the study of adsorption isotherms on these gels, they were found to exhibita higher adsorption capacity than the majority of those reported to date.
Implant Stability of Biological Hydroxyapatites Used in Dentistry
Authors: Ramírez Fernández Maria , Gehrke Sergio , Mazón Patricia , Calvo-Guirado Jose , De Aza Piedad
Published: June 2017

The aim of the present study was to monitor implant stability after sinus floor elevation with two biomaterials during the first six months of healing by resonance frequency analysis (RFA), and how physico-chemical properties affect the implant stability quotient (ISQ) at the placement and healing sites. Bilateral maxillary sinus augmentation was performed in 10 patients in a split-mouth design using a bobine HA (BBM) as a control and porcine HA (PBM). Six months after sinus lifting, 60 implants were placed in the posterior maxilla. The ISQ was recorded on the day of surgery from RFA at T1 (baseline), T2 (three months), and T3 (six months). Statistically significant differences were found in the ISQ values during the evaluation period. The ISQ (baseline) was 63.8 ± 2.97 for BBM and 62.6 ± 2.11 for PBM. The ISQ (T2) was ~73.5 ± 4.21 and 67 ± 4.99, respectively. The ISQ (T3) was ~74.65 ± 2.93 and 72.9 ± 2.63, respectively. All of the used HAs provide osseointegration and statistical increases in the ISQ at baseline, T2 and T3 (follow-up), respectively. The BBM, sintered at high temperature with high crystallinity and low porosity, presented higher stability, which demonstrates that variations in the physico-chemical properties of a bone substitute material clearly influence implant stability.
Magnetically Assisted Bilayer Composites for Soft Bending Actuators
Authors: Jang Sung-Hwan , Na Seon-Hong , Park Yong-Lae
Published: June 2017

This article presents a soft pneumatic bending actuator using a magnetically assisted bilayer composite composed of silicone polymer and ferromagnetic particles. Bilayer composites were fabricated by mixing ferromagnetic particles to a prepolymer state of silicone in a mold and asymmetrically distributed them by applying a strong non-uniform magnetic field to one side of the mold during the curing process. The biased magnetic field induces sedimentation of the ferromagnetic particles toward one side of the structure. The nonhomogeneous distribution of the particles induces bending of the structure when inflated, as a result of asymmetric stiffness of the composite. The bilayer composites were then characterized with a scanning electron microscopy and thermogravimetric analysis. The bending performance and the axial expansion of the actuator were discussed for manipulation applications in soft robotics and bioengineering. The magnetically assisted manufacturing process for the soft bending actuator is a promising technique for various applications in soft robotics.
Application of Computational Chemical Shift Prediction Techniques to the Cereoanhydride Structure Problem—Carboxylate Complications
Authors: Saunders Carla , Tantillo Dean
Published: June 2017

Despite the vast array of techniques available to modern-day chemists, structural misassignments still occur. These misassignments are often only realized upon attempted synthesis, when the spectra of synthesized products do not match previously reported spectra. This was the case with marine natural product cereoanhydride. The originally proposed 7-membered ring anhydride (1) was shown to be incorrect, although a likely precursor to the correct structure (2) in both its laboratory synthesis and biosynthesis. Herein, in addition to showing how NMR computations could have been used to arrive at the correct structure, we show that the conversion of 1 to 2 is indeed energetically viable, and we highlight complications in predicting NMR chemical shifts for molecules with acidic protons.
Marine Sponges and Bacteria as Challenging Sources of Enzyme Inhibitors for Pharmacological Applications
Authors: Ruocco Nadia , Costantini Susan , Palumbo Flora , Costantini Maria
Published: June 2017

Enzymes play key roles in different cellular processes, for example, in signal transduction, cell differentiation and proliferation, metabolic processes, DNA damage repair, apoptosis, and response to stress. A deregulation of enzymes has been considered one of the first causes of several diseases, including cancers. In the last several years, enzyme inhibitors, being good candidates as drugs in the pathogenic processes, have received an increasing amount of attention for their potential application in pharmacology. The marine environment is considered a challenging source of enzyme inhibitors for pharmacological applications. In this review, we report on secondary metabolites with enzyme inhibitory activity, focusing our attention on marine sponges and bacteria as promising sources. In the case of sponges, we only reported the kinase inhibitors, because this class was the most representative isolated so far from these marine organisms.
Effect of Supercritical Carbon Dioxide Extraction Parameters on the Biological Activities and Metabolites Present in Extracts from Arthrospira platensis
Authors: Esquivel-Hernández Diego , Rodríguez-Rodríguez José , Cuéllar-Bermúdez Sara , García-Pérez J. , Mancera-Andrade Elena , Núñez-Echevarría Jade , Ontiveros-Valencia Aura , Rostro-Alanis Magdalena , García-García Rebeca , Torres J. , Chen Wei , Parra-Saldívar Roberto
Published: June 2017

Arthrospira platensis was used to obtain functional extracts through supercritical carbon dioxide extraction (SFE-CO2). Pressure (P), temperature (T), co-solvent (CX), static extraction (SX), dispersant (Di) and dynamic extraction (DX) were evaluated as process parameters through a Plackett–Burman design. The maximum extract yield obtained was 7.48 ± 0.15% w/w. The maximum contents of bioactive metabolites in extracts were 0.69 ± 0.09 µg/g of riboflavin, 5.49 ± 0.10 µg/g of α-tocopherol, 524.46 ± 0.10 µg/g of β-carotene, 1.44 ± 0.10 µg/g of lutein and 32.11 ± 0.12 mg/g of fatty acids with 39.38% of palmitic acid, 20.63% of linoleic acid and 30.27% of γ-linolenic acid. A. platensis extracts had an antioxidant activity of 76.47 ± 0.71 µg GAE/g by Folin–Ciocalteu assay, 0.52 ± 0.02, 0.40 ± 0.01 and 1.47 ± 0.02 µmol TE/g by DPPH, FRAP and TEAC assays, respectively. These extracts showed antimicrobial activity against Staphylococcus aureus ATCC 25923, Pseudomonas aeruginosa ATCC 27853, Escherichia coli ATCC 25922 and Candida albicans ATCC 10231. Overall, co-solvent was the most significant factor for all measured effects (p < 0.05). Arthrospira platensis represents a sustainable source of bioactive compounds through SFE using the following extraction parameters P: 450 bar, CX: 11 g/min, SX: 15 min, DX: 25 min, T: 60 °C and Di: 35 g.
Synthesis, Antimicrobial, and Antioxidant Activities of Chalcogen-Containing Nitrone Derivatives from (R)-citronellal
Authors: Ferraz Mariana , Mano Renata , Oliveira Daniela , Maia Darla , Silva Wladimir , Savegnago Lucielli , Lenardão Eder , Jacob Raquel
Published: June 2017

Background: The main constituents of Cymbopogonnardus (L) Rendle and C. citratus (DC) Stapfessential oils are (R)-citronellal and citral, respectively. Organochalcogen compounds can boost the biological activities of natural products. Methods: Several chalcogen-containing nitrones derived from (R)-citronellal and citral were prepared and evaluated for their antimicrobial and antioxidant activities. The antimicrobial activity was evaluated by the disc diffusion test and the antioxidant properties were evaluated in vitro by DPPH (1,1-diphenyl-2-picryl-hydrazyl), ABTS (2,2′-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid), and FRAP (ferric ion reducing antioxidant power) assays. Results: In the antimicrobial assay, (E)-N,3,7-trimethyl-3-(phenylthio)oct-6-en-1-imine oxide 5c exhibited halos between 21.5 mm (Escherichia coli O157:H7) and 26.0 mm (Listeria monocytogenes), while (E)-N,3,7-trimethyloct-6-en-1-imine oxide 5d presented halos between 22.5 mm (E. coli O157:H7) and 31.0 mm (L. monocytogenes). (E)-N,3,7-Trimethyl-2-(phenylthio)oct-6-en-1-imine oxide 5a showed the lowest minimal inhibitory concentration (MIC) value against Bacillus cereus (0.48 mM), and 5c was the most potent bactericide, with a minimal bactericidal concentration (MBC) of 0.52 mM for E. coli O157:H7. In the antioxidant assays, 5c, 5d, and 10 ((E)-3,7-dimethyl-2-(phenylselanyl)oct-6-enal oxime) were the most actives in the DPPH, ABTS, and FRAP assays, respectively. Conclusions: The presence of a phenylthio group in the nitrone increases its antimicrobial activity against Gram-positive and Gram-negative foodborne pathogens in the disk diffusion test and the antioxidant activity in vitro.
Low Field Magnetic and Thermal Hysteresis in Antiferromagnetic Dysprosium
Authors: Liubimova Iuliia , Corró Moyà Miguel , Torrens-Serra Joan , Recarte Vicente , Pérez-Landazábal José , Kustov Sergey
Published: June 2017

Magnetic and thermal hysteresis (difference in magnetic properties on cooling and heating) have been studied in polycrystalline Dy (dysprosium) between 80 and 250 K using measurements of the reversible Villari effect and alternating current (AC) susceptibility. We argue that measurement of the reversible Villari effect in the antiferromagnetic phase is a more sensitive method to detect magnetic hysteresis than the registration of conventional B(H) loops. We found that the Villari point, recently reported in the antiferromagnetic phase of Dy at 166 K, controls the essential features of magnetic hysteresis and AC susceptibility on heating from the ferromagnetic state: (i) thermal hysteresis in AC susceptibility and in the reversible Villari effect disappears abruptly at the temperature of the Villari point; (ii) the imaginary part of AC susceptibility is strongly frequency dependent, but only up to the temperature of the Villari point; (iii) the imaginary part of the susceptibility drops sharply also at the Villari point. We attribute these effects observed at the Villari point to the disappearance of the residual ferromagnetic phase. The strong influence of the Villari point on several magnetic properties allows this temperature to be ranked almost as important as the Curie and Néel temperatures in Dy and likely also for other rare earth elements and their alloys.