bluuebunny/crossref_metadata_2025 huggingface dataset:
Nonprofit Planning and Impact with Regard to the 2018 Tax Law
Authors: Padot Rebecca
Published: May 2023

The Tax Cuts and Jobs Act (TCJA) is considered the largest tax overhaul since 1986 and was anticipated to produce declining charitable donations for nonprofits and was expected to create disruption across the nonprofit sector in 2018. This study tests whether small nonprofits (under $250,000 in revenues) or large nonprofits (over $250,000 in revenues) planned differently due to the law and secondly, how they were affected by the law. Utilizing survey data from 50 nonprofits, this research offers qualitative data on both large and small nonprofit organizational awareness as it relates to the rollout of the law.
Book Heritage in the Collection of the National Museum of the Komi Republic
Authors: Kraeva N. V.
Published: May 2023

The Scientific Library of the National Museum of the Komi Republic is one of the oldest libraries in the region. For more than 110 years of its history, a unique book collection has been formed, containing rare printed editions of the mid-18th - early 20th centuries from private collections of famous scientists, public figures, writers, teachers, as well as books and periodicals of scientific, educational and other government institutions of both the Komi region and Russia. The purpose of the article is to outline the main stages in the history of the Scientific Library of the National Museum of the Komi Republic collection, designed to identify and expose its unique rare editions for visitors.

The first stage (1911-1919) is connected with the activities of the Ust-Sysolsk local historians and the Arkhangelsk Society for the Study of the Russian North, the second (1920-1930) was conducted by the Society for the Study of the Komi Territory. The third stage is limited by the period of the Great Patriotic War. Archaeographic expeditions for to collect handwritten books and early printed publications became significant for the fourth (1960s-1970s) period.

In 2011, a new stage began in the life of the library, associated with the transfer of the book stock to the building of the Literary Museum named after I. Kuratov, one of the departments of the museum. When creating the space of the Literary Museum, a special place was assigned to the scientific library: the combination of the educational resource of the exposition and the scientific library with the reading room and book storage. Research activity is one of the main directions in the work of the library. Studies are actively carried out aimed at scientific and bibliographic description and examination of rare editions, identification, attribution and cataloging of book signs. Publications covering the results of researches become the concluding summing up both at the regional and Russian levels. The priority direction is a wide demonstration of their collections using computer technologies, which contributes to the expansion of opportunities for public access to rare book collections and allows expanding the list of visitors.
Helping the School: Electronic Learning Resources of Foreign Libraries
Authors: Barysheva E. A.
Published: May 2023

The transition from an information society to a knowledge society gives libraries a chance to overcome the crisis by transforming themselves into educational institutions of a new type, providing quality information and educational services that promote cognitive and creative activities. An important place among them belongs to programs and projects for the creation and promotion of electronic learning resources intended for schoolteachers and students, i.e. for the audience, which directly determines the society we will have to live in the near future. The aim of the article is to consider the experience of major foreign libraries in preparing electronic learning (e-Learning) resources for schools from the perspective of their possible use by Russian libraries in the light of the tasks set to strengthen the role of cultural and educational organizations in the historical and cultural enlightenment and upbringing of the growing generation. The object of the article is the resources of own generation (or created in cooperation with other institutions) of national and regional libraries in the USA, Great Britain, and Australia, related to the methodological support of the educational process in schools. The study of the content of these resources made it possible to identify several main groups with different purposes: training in the skills of working with primary sources; promotion of classical literature and reading; assistance to subject teachers in their work with current social and political issues; development of regional / local history knowledge. Examples explored are electronic learning resources for schools posted in dedicated sections or on the web portals of the Library of Congress (USA, Washington), the National Library of Australia, the British Library, the Florida State Library and Archives, the State Library of Victoria (Australia, Melbourne) the National Library of Scotland, and the National Library of Wales. The study has shown that national and regional libraries of the above-mentioned countries place a high priority on the preparation of electronic learning resources for schools. Creation of such resources helps libraries to solve important tasks: to popularize their collections and electronic resources; to expand the circle of regular readers by attracting schoolchildren; to enhance the prestige of the library as an important cultural and educational institution involved in forming the worldview and raising the intellectual level of the younger generation. Due to their social significance, such projects, as a rule, have state or regional funding; grants are widely practiced. The article pays special attention to the interaction between libraries and other cultural institutions in preparing joint electronic learning resources for schools, as well as to the promotion of such resources among the teaching community, primarily through close cooperation with pedagogical organizations.
International Scientific and Practical Conference «Science, Technology and Information in Libraries (Libway-2023)». Brief summary
Authors: Alshevskaya O. N. , Artemyeva E. B. , Borodikhin A. Yu. , Busygina T. V. , Kurmysheva L. K. , Lizunova I. V. , Makhotina N. V. , Minakov A. G. , Novikova N. V. , Pleshakova M. A. , Pshenichnaya E. V. , Redkina N. S.
Published: May 2023

Международная научно-практическая конференция «Наука, технологии и информация в библиотеках (Libway-2023)» состоялась 20–22 марта в Новосибирске.
Bell's Theorem Begs the Question
Authors: Christian Joy
Published: May 2023

I demonstrate that Bell's theorem is based on circular reasoning and thus a fundamentally flawed argument. It unjustifiably assumes the additivity of expectation values for dispersion-free states of contextual hidden variable theories for non-commuting observables involved in Bell-test experiments, which is tautologous to assuming the bounds of ±2 on the Bell-CHSH sum of expectation values. Its premises thus assume in a different guise the bounds of ±2 it sets out to prove. Once this oversight is ameliorated from Bell's argument, the bounds on the Bell-CHSH sum of expectation values work out to be ±2√2 instead of ±2, thereby mitigating the conclusion of Bell's theorem. Consequently, what is ruled out by the Bell-test experiments is not local realism but the additivity of expectation values, which does not hold for non-commuting observables in any hidden variable theories to begin with.
Neural Networks and Adapted Optimal Transport
Authors: Garbelli Matteo , Di Persio Luca
Published: May 2023

Within Data Science scenario both Machine Learning (ML) and Neural Networks (NNs) are widely used for a plethora of applications, spanning from engineering to biology, from finance to medicine. Meanwhile, the pure analytical analysis of related models used often lacks of detailed description. Trying to close this gap, during recent years the theory of Optimal Transport start becoming more a more popular within the Data Science arena, since it allows for efficient and scalable solutions about what can be broadly referred as Artificial Intelligence tasks, particularly by using approximate solvers through linear programming. More precisely, let us recall that both in ML and statistics, minimizing an objective function over the space of probability measures is fundamental problem. Along this line, the training of a Neural Network through Stochastic Gradient Descent has been shown to be equivalent to a gradient flow in Wasserstein space. Moreover, in many applications, it is crucial to consider the causal structure of the data generating process. In view of providing a possibly unifying as well as efficient approach to latter questions, we consider the Adapted Optimal Transport (AOT) method which allows to incorporate causality constraints into the optimization of the Wasserstein distance. AOT is particularly useful when dealing with laws of stochastic processes, being exploitable to encode an adapted (non-anticipative) constraint into the allocation of mass of the classical OT problem. Accordingly, we provide an in depth exploration of the connections between supervised learning and AOT, providing theoretical insights into the benefits of including causality constraints for developing more robust, scalable and accurate algorithms, while maintainig their computational efforts at minimum possible levels.
Predictive Cell-Culture Time-Evolution Based on Electric Models
Authors: Serrano Juan Alfonso , Perez Pablo , Daza Paula , Huertas Gloria , Yúfera Alberto
Published: May 2023

The cell concentration measurement on a culture assay using bioimpedance is a very useful tool, but it is complex to translate impedance to cell concentration values. The purpose of this work is to find a method to obtain in real time the cell concentration values for a given cell-culture assay using an oscillator as the measurement circuit. From a basic cell-electrode model, enhanced models of the cell culture immersed in a saline solution (culture medium) can be derived. These models can be used in a fitting routine to real time estimation of the cell concentration in a cell culture, using the oscillation frequency and amplitude delivered by measurement circuits proposed by the authors. Based on real experimental data (frequency and amplitude of oscillations) obtained by connecting the cell culture to an oscillator as a load, the fitting routine is simulated, and real time data of cell concentration is achieved. These results are compared with concentration data found by traditional optical methods for counting. In addition, the error obtained is divided and analyzed in two parts: in the first part of the experiment (when the few cells are adapting to the culture medium) and the second part of the experiment (when the cells grow exponentially until they completely cover the well).Low error values are obtained in the growth phase of the cell culture (the relevant phase), therefore the results obtained are considered to be promising, proving that the fitting routine is valid, and that the cell concentration can be measured in real time using an oscillator.
The Power of Symmetries in Nuclear Structure and Some of Its Problems
Authors: Hess Peter
Published: May 2023

A review on several classical, algebraic models in nuclear structure physics, which use symmetries as an important tool, are presented. After a conceptual introduction to group theory, a selection of models is chosen to illustrate the methods and the power of the usage of symmetries. It enables to describe very involved systems in a greatly simplified manner. Some problems are also discussed, when ignoring basic principles of nature, as the Pauli Exclusion principle. We also show that, nevertheless, occasionally one can rescue these omissions. In a couple of representative models, applications of symmetries are explicitly applied, in order to illustrate how extremely complicate systems can be treated. This contribution is meant bas a review on the use of algebraic models in nuclear physics, leading to a better understanding of the articles in the same special volume.
Adhesive Single-Lap Joints Evaluation Using Ultrasonic Guided Waves
Authors: Santos Mário , Santos Jaime Batista
Published: May 2023

This work deals with the evaluation of adhesive single-lap joints using ultrasonic guided waves. An adhesive bonded lap joint can be modelled as a three-layer system made up of two adherents and an adhesive. The propagation of guided waves in the joint is developed from matrix formulations. The behavior of the different guided wave modes that propagate in the bonded region is characterized and it is found that their relative amplitudes can be estimated based on the properties of the incoming wave that propagates in the non-bonded region. It was verified that the excitation of these modes is ruled by the degree in which the shapes of both modes match each other. A 3D simulation of two aluminium bonded plates using 500 kHz ultrasonic transducers in a pitch and catch configuration was implemented using the Matlab k-Wave toolbox. Scattering effects due to some produced defects located in the bond line of the lap joints were simulated. Experimental setup with some artificial defects produced in the aluminum joints were used in order to compare with the simulated. Qualitative agreement was observed for the two approaches. The observed deviation can be due to the different characteristics of the experimental and simulated defects.
Immunotherapy with PD-1 Inhibitor Nivolumab in Recurrent/Metastatic Platinum Refractory Head and Neck Cancers: The Early Experience of Two Academic Center
Authors: Mireștean Camil Ciprian , Stan Mihai Cosmin , Schenker Michael , Volovăț Constantin , Volovăț Simona Ruxandra , Iancu Dragoș Petru Teodor , Iancu Roxana Irina , Florinel Badulescu
Published: May 2023

The prognosis of patients with recurrent or metastatic of the head and neck squamous-cell carcinoma (HNSCC) refractory to platinum-based chemotherapy is severe and, consequently, the identification of therapeutic options for this category of patients is a priority. Nivolumab, an anti- programmed cell death protein 1 (anti-PD-1) monoclonal antibody, has been approved for the treatment of recurrent or metastatic HNSCC after platinum-based therapy progressing. We present the early experience of two academic center including diagnostic, clinical, biological, therapeutic and outcomes characteristics of head and neck cancer (HNC) patients treated with Nivolumab. The purpose of the study is to identify certain peculiarities and to report them compared to the data from the literature in order to generate some hypotheses that coud constitute criteria for the selection of cases with maximum benefit to immunotherapy. Analyzing the data obtained from 18 patients treated in Emergency County Hospital Craiova, "Saint Nectarie" Oncological Hospital Craiova and Euroclinic Oncological Center Iasi January 2020 and March 2023 it could be hypothesized that lower nadir values of neutrophil to lymphocyte ratio (<3.5) and the adition of intensive regimens of chemotherapy and radiotherapy could justify a favorable response in terms of progression free survival (PFS) during immunotherapy with Nivolumab. To our knowledge, the study included the first two cases of second primary malignancy (SPM) in the head neck region treated with Nivolumab. The reported data support a possible benefit of the sequential administration of radiotherapy, immunotherapy for SPM cases. Higher positive dynamic of neutrophil to lymphocyt ratio (NLR) could be associated with worst outcome during immunotherapy. All study observations including the role of infections and antibiotic treatment as well as the possible biomarker value of NLR variation during immunotherapy should be investigated in multicenter clinical trials.
Intra-Articular Facet Joint Injection of Normal Saline for Chronic Low Back Pain: A Systematic Review and Meta-Analysis
Authors: Suputtitada Areerat , Nopsopon Tanawin , Rittiphairoj Thanitsara , Pongpirul KRIT
Published: May 2023

Objective: This systematic review and meta-analysis compared the patient-reported outcomes of intra-articular facet joint injections of normal saline and selected active substances to identify a more effective agent for treating subacute and chronic low back pain (LBP). Methods: The PubMed, Embase, Scopus, Web of Science, and CENTRAL databases were searched for randomized controlled trials and observational studies published in English. A research quality assessment was performed using ROB2 and ROBINS-I. A meta-analysis was conducted using a random-effects model, and the mean differences (MD) with 95% confidence intervals (CI) in efficacy outcomes, including pain, numbness, disability, and quality of life, were assessed. Results: Of the 2,467 potential studies, three were included (247 patients). The active substances and normal saline had similar therapeutic effects on pain within 1 h, after 1-1.5 months, and after 3-6 months, with MD and 95% CI of 2.43 and -11.61 to 16.50, -0.63 and -7.97 to 6.72, and 1.90 and -16.03 to 19.83, respectively, as well as the quality of life after 1 and 6 months. Conclusion: The short- and long-term clinical effects of intra-articular facet joint injections of normal saline are comparable to those of other active substances in patients with LBP.
Reducing the Risk of Disasters Caused by Epidemics
Authors: Cvetković Vladimir M. , Vujanović Slavica , Ivanov Aleksandar
Published: May 2023

Epidemics are the most common natural phenomena that have occurred throughout the entire history of human society. Depending on the type of disease and the development of the collective immunity that society had acquired by then, the consequences of epidemics were usually very severe. Precisely because of this, the aim of the paper is a scientific description of the way in which the prescribed preventive measures should be applied from the epidemiological, security, economic, legal and other aspects, so that the society, through the mechanisms of the state, can defend and rehabilitate the consequences of an epidemic of an infectious disease. Eliminating the epidemic's impacts is a very difficult issue. In particular, there is an infectious illness epidemic that is spreading uncontrolled throughout society on the one hand. In order to introduce a quarantine that restricts the epidemic's progress and, if the quarantine lasts long enough, to end the epidemic, contact between members of the social group must be broken. On the other side, the cessation of communication between members of a social group also signifies the cessation of all facets of life in that society, including economic ties, education, growth of culture, scientific research, etc.
Physiological and Transcriptomic Analysis Provides Insights into Low Nitrogen Stress in Foxtail Millet (Setaria italica L.).
Authors: Chen Erying , Qin Ling , Li Feifei , Yang Yanbing , Liu Zhenyu , Yu Xiao , Niu Jiahong , Wang Runfeng , Zhang Huawen , Wang Hailian , Liu Bin , Guan Yanan
Published: May 2023

Foxtail millet (Setaria italica (L.) P. Beauv) is an important food and forage crop that is well adapted to nutrient-poor soils. However, little is known about how foxtail millet adapts to low nitrogen (LN) at the physiological and molecular levels. In the present study, two foxtail millet varieties with contrasting low nitrogen (LN) tolerance properties were investigated through integrative analyses of physiological featureparameters and transcriptomics. The physiological results showed that JG20 (high tolerance to LN) had higher biomass accumulation, nitrogen content and nitrogen use efficiency compared with JG22 (low tolerancesensitive to LN) under LN. JG20 had higher soluble sugar and soluble protein concentration in shoots compared with JG22 under LN, while contcentrations of soluble sugar and soluble protein contents were higher in the roots of JG22. Higher levels of CTK contentzeatin concentration were found in the shoots of JG20 com-pared with JG22, and a higher ABA contcentration was found in both the shoots and roots of JG22 compared with JG20 under LN. In the transcriptomics results, JG20 had more differentially ex-pressed genes (DEGs) than JG22 both in shoots and roots in response to LN. These LN-responsive genes were enriched in glycolysis, starch and sucrose metabolism, photosynthesis, biosynthesis of amino acids, hormone metabolism and nitrogen metabolism. Furthermore, the high-affinity nitrate transporter gene, SiNRT2.1, and glutamine synthetase gene, SiGS5, chlorophyll apoprotein of photosystem II gene, SiPsbQ, ATP synthase subunit gene, b, auxin-responsive protein gene, SiIAA25, and aldose 1-epimerase gene, SiAEP, in shoots, and high-affinity nitrate transporter gene, SiNRT2.3, SiNRT2.4, and glutamate synthase gene, SiGOGAT2, auxin-responsive protein gene, SiIAA4, fructose-bisphosphate aldolase gene, SiAEP5, in root, were important genes in-volved in the LN tolerance of foxtail millet. These results provide a detailed description of the physiological and transcriptome response of foxtail millet under LN condition.
Electromagnetic Waves in Cosmological Spacetime
Authors: Staicova Denitsa , Stoilov Michail
Published: May 2023

We consider the propagation of electromagnetic waves in the Friedman – Lemaître – Robertson – Walker metric. The exact solutions for plane and spherical wave are written down. The corresponding redshift, amplitude change, and dispersion are discussed. We also speculate about the connection of the electromagnetic wave equation to the Klein–Gordon equation.
Human Sperm Head Vacuoles Are Related to Nuclear-Envelope Invaginations
Authors: Gómez-Torres María José , Luna-Romero Javier , Fernández-Colom Pedro José , Aizpurua Jon , Avilés Manuel , Romero Alejandro
Published: May 2023

Nuclear vacuoles are specific structures present on the head of the human sperm of fertile and non-fertile men. Human sperm head vacuoles have been previously studied using motile sperm organelle morphology examination (MSOME) and their origin related to ab-normal morphology, abnormal chromatin condensation and DNA fragmentation. How-ever, other evidences argued that human sperm vacuoles are physiological structures and consequently, to date, the nature and origin of the nuclear vacuoles remains to be elucidat-ed. Here, we aim to define the incidence, position, morphology, and molecular content of the human sperm vacuoles using transmission electron microscopy (TEM) and immuno-cytochemistry techniques. Results showed that ~50% of the analyzed human sperm cells (n = 1908; 17 normozoospermic human donors) contained vacuoles mainly located (80%) in the anterior head region. A significant positive correlation was also found between the sperm vacuole and nucleus areas. Furthermore, it was confirmed that nuclear vacuoles were invaginations of nuclear envelope containing cytoskeletal proteins and a cytoplas-mic enzyme, discarding a nuclear or acrosomal origin. According to our findings, these human sperm head vacuoles are cellular structures which take the origin from nuclear invaginations and contain perinuclear theca (PT) components, allowing to define a new term of ‘nuclear invaginations’ rather than ‘nuclear vacuoles.
Exploring COVID-19 Pandemic Impact, Online Engagement, and Digital Divide on Disadvantaged Undergraduate Students in South African Universities
Authors: Odularu Ayodele Temidayo , Khalo Xolani , Mashiyi Nomakhaya F. , Nkohla Msimelelo B
Published: May 2023

Abstract
This qualitative research study was aimed at exploring Covid-19 pandemic and its impact via online engagement on disadvantaged undergraduate students resulting in digital divide. The study was supported by the connectivism theory. The methodology approach was an eight year (2014-2022) duration systematic literature review using Educational Resources Information Center (ERIC), Google Scholar, Scopus, and Web of Science (WoS) databases as advanced search strategies. Findings from the SLR provided 56 included relevant publications as confirmed in the Reference Section. Here, findings justified factors responsible for digital divide and the digital divide impacts. Connectivism was suggested as an approach to control digital divide. This study recommends connectivism to control digital divide experienced among disadvantaged undergraduate students in South African universities via numerous supports for free trainings in computer skills, while the government provides low data cost and free Wi-Fi services.
Research and Development Status of Selective Laser melting (SLM)
Authors: Li Wenqing , Li Yun , Huang Guangcan , Wu Suisong , Liu Wumeng , Guo Chun
Published: May 2023

With the development of industrialization, traditional manufacturing technologies are no longer able to meet the production needs of modern society. Additive manufacturing has successfully solved the problems existing in traditional manufacturing technology. Selective laser melting (SLM) is a powder bed melting technology that produces metal parts by selectively melting metal powders on a platform using a laser beam. It is widely used in additive manufacturing. This article introduces the characteristics and current development status of SLM technology, summarizes the main application fields and common defects of SLM, and finally explores and prospects the future development trend of SLM.
Unraveling Peritoneal Carcinomatosis on Cross-Sectional Imaging Modalities
Authors: Veron Sanchez Ana , Bennouna Ilias , Coquelet Nicolas , Cabo Bolado Jorge , Pinilla Fernandez Inmaculada , Mullor Delgado Luis Alberto , Pezzullo Martina , Liberale Gabriel , Gomez Galdon Maria , Bali Maria Antonietta
Published: May 2023

Among cross-sectional imaging modalities, computed tomography (CT) is more available and faster; however, magnetic resonance (MR) performs better in terms of sensitivity and specificity, due to its higher contrast resolution. The appearance of peritoneal deposits on CT and MR depends mainly on the primary tumour histology: in case of unknown primary tumour (3-5% of cases), their behaviour at imaging may provide insights on the tumour origin. The time-point of tumour evolution, previous or ongoing treatments and the peritoneal spaces where they occur, also play an important role in determining the appearance of peritoneal deposits. Thus, knowledge of peritoneal anatomy and fluid circulation is mandatory in detection and characterization of peritoneal deposits. Several benign and malignant conditions may show similar imaging features that overlap those of PC, making the differential diagnosis challenging. Clinical history, laboratory findings and previous imaging examinations must be considered to achieve the correct diagnosis.
Pneumatic Compression Combined with Standard Treatment after Total Hip Arthroplasty: Effects on Edema of the Operated Limb and on Physical Outcomes. A Clinical Randomized Control Trial
Authors: Carnevale Pellino Vittoria , Gatti Alessandro , Vandoni Matteo , Patanè Pamela , Febbi Massimiliano , Ballarin Stefania , Cavallo Caterina , Marin Luca
Published: May 2023

Total hip arthroplasty (THA) is one of the most successful orthopedic procedures and is highly effective in improving function and quality of life. However, after discharge patients commonly experience edema, which can lead to health consequences and lower quality of life. For these rea-sons, the aim of this study is to evaluate the effectiveness of a specific intermittent leg pneumatic compression on lower limb edema and physical outcomes in patients after total hip arthroplasty, compared to standard conservative treatment. A total of 47 patients were enrolled and randomly allocated into two groups: the pneumatic compression group (PG=24) and the control group (CG=23). We evaluated thigh and calf circumferences, knee and ankle range of motion, pain and walking autonomy. Our results showed a greater reduction in thigh and calf circumference for PG (p<0.001), while other outcomes were similar for the two groups (p>0.05). The combination of standard therapy with pneumatic leg compression was more effective in reducing lower limb edema, thigh, and calf circumferences compared to the use of standard treatment. Our results suggest that pressotherapy treatment is a valuable and efficient option for managing lower limb edema and preventing VTE after THA.
Prevalence of Clinical Signs and Symptoms of Temporomandibular Joint Disorders Registered in the EUROTMJ Database: A Prospective Study in a Portuguese Center
Authors: Ângelo David Faustino , Mota Beatriz , João Ricardo São , Sanz David , Cardoso Henrique José
Published: May 2023

Temporomandibular joint disorders (TMD) are characterized by their multifactorial etiology and pathogenesis. A 3-year prospective study was conducted in a Portuguese TMD department to study the prevalence of different TMD signs and symptoms and their association with risk factors and comorbidities. Five hundred ninety-five patients were included using an online database: EUROTMJ. Most patients were female (80.50 %), with a mean age of 38.20±15.73 years. The main complaints were temporomandibular joint (TMJ) clicking (13.26%), pain (12.49%), and masticatory muscle tension (12.15%). The main clinical findings were myalgia (74%), TMJ clicking (60-62%) and arthralgia (31-36%). Risk factors such as clenching (60%) and bruxism (30%) were positively associated with TMJ pain and myalgia. Orthodontic treatment (20%) and wisdom tooth removal (19%) were positively associated with TMJ clicking, while jaw trauma (6%) tracheal intubation (4%) and orthognathic surgery (1%) were positively associated with TMJ crepitus, limited man-dibular range of motion and TMJ pain, respectively. 42.88% of TMD patients had other associated chronic diseases, most of them were mental behavioral or neurodevelopmental disorders (33.76%), namely, anxiety (20%) and depression (13%). The authors also observed a positively association of mental disorders with the degree of TMJ pain and myalgia. Online database seems to be a relevant scientific instrument for healthcare providers who treat TMD. The authors expect that EUROTMJ database can serve as a milestone for other TMD departments.
Multiomic Investigations into Lung Health and Disease
Authors: Blutt Sarah E , Coarfa Cristian , Neu Josef , Pammi Mohan
Published: May 2023

Diseases of the lung account for more than 5 million deaths worldwide and are a burden to healthcare. Improving clinical outcomes including mortality and quality of life involves a holistic understanding the etiopathogenesis, which can be provided by multi-omics integration of lung data. An enhanced understanding of large comprehensive datasets provides opportunities to mine those datasets for features that contribute to prevention and amelioration of disease. In this review, we evaluate lung disease models including animal models, organoids and single cell lines as mechanisms to study multiomics in lung health and disease. We provide examples of lung diseases where multi-omics investigations have provided a deeper insight into pathogenesis that has resulted in improved preventive and therapeutic interventions.
Factors Contributing to the Long-Term Sea Level Trends in the Iberian Peninsula and the Balearic and Canary Islands
Authors: Vargas-Yáñez Manuel , Tel Elena , Marcos Marta , Moya Francina , Ballesteros Enrique , Alonso Cristina , García-Martínez M. Carmen
Published: May 2023

We present an attempt to estimate the long-term changes of Relative Sea Level (RSL) and the different factors contributing to such trends on a local and regional scale using a statistical linear model. The time series analysed correspond to 17 tide-gauges grouped in three different areas: the northern and western Atlantic coasts of the Iberian Peninsula, the Canary Islands, and the southern and eastern coasts of the Iberian Peninsula and Balearic Islands. The analysis was performed for two periods: 1948-2019, using tide-gauge data, and 1993-2019, using both tide-gauge and altimetry data for comparison. The trends for the period 1948-2019 ranged between 1.09 0.14 (Canary Islands) and 2.05 0.21 mm/yr, for the northern and western Atlantic Iberian Peninsula. Altimetry data during the period 1993-2019 yielded quite homogeneous results for all the locations and regions, ranging between 2.7 0.4 and 3.0 0.3 mm/yr. On the contrary, the results obtained from tide-gauge data for this recent period showed a large dispersion, very likely due to local effects or even levelling or instrumental errors. Nevertheless, when the results were averaged for each area, the observed trends were comparable to the altimetry results, with values of 2.3 0.8, 2.7 0.5 and 2.8 0.8 mm/yr for the three regions of study. A stepwise forward linear regression has been used to relate the observed RSL variability to the atmospheric forcing and the thermosteric and halosteric components of the sea level. Surprisingly, the thermosteric and halosteric contributions were not significantly correlated to the observed RSL in many cases, and consequently the steric, the total addition of mass, the mass of salt, and the freshwater contributions to the observed sea level trends could not be reliably estimated. This result seems to be the consequence of the scarcity of temperature and salinity data. This hypothesis is confirmed by the exception of L’Estartit tide-gauge. This location is close to a well sampled region. In this case, the atmospheric variables and the thermosteric and halosteric terms explained the 80 % of the observed RSL variance and the contributions of these terms could be estimated. The freshwater contribution for this location was between 1.3 and 1.4 mm/yr, consistent with recent estimations of the contributions of glaciers and Greenland and Antarctica Ice Sheets. These results highlight the importance of monitoring programs and routine sampling for the determination of the different factors contributing to the sea level variability.
Entomopathogenic Fungi: An Eco-Friendly Synthesis of Sustainable Nanoparticles and Their Nanopesticide Properties
Authors: Bihal Ritu , Al-Khayri Jameel M , Banu A. Najitha , Kudesia Natasha , Ahmed Farah K. , Sarkar Rudradeb , Arora Akshit , Abd-Elsalam Kamel A.
Published: May 2023

Citation: To be added by editorial staff during production.
Non-catalytic and Catalytic Conversion of Fruit Waste to Synthetic Liquid Fuel via Pyrolysis
Authors: Pehlivan Eylem
Published: May 2023

In terms of obtaining fuels as well as chemicals with or without catalysts at different conditions, the plum seed stands out as an alternative biomass source. Under varying heating rates (10, 50, and 100ºC min-1) and pyrolysis temperatures (400, 450, 500, 550 and 600 °C), the plum seed was pyrolysed at constant sweep gas flow at a constant rate (100 cm3min-1) in a tubular fixed bed reactor. According to the results, an oil yield reaching to a maximum of %45 was procured at the heating rate of 100 ºCmin-1 and the pyrolysis temperature of 550ºC in non-catalytic procedure. The catalytic pyrolysis was carried out in optimum conditions with two selected commercial catalysts, namely ZSM-5 and PURMOL-CTX and clinoptilolite (natural zeolite, NZ) with catalyst ratio of 10 % of raw material. Along with the catalyst addition, the quantity and the quality of bio-oil increased including the calorific value, removal of oxygenated groups, and hydrocarbon distribution. An increase related to the desirable products like phenols, alkene, and alkane and a decrease in undesirable products like acids were observed in the presence of catalysts. When all the results are considered and evaluated, using zeolite materials in the pyrolysis as catalysts is a recommendable option to achieve enhanced chemicals and fuels.
Switching Performance Enhancement in Gallium Oxide-based Multilevel RRAM Devices using Graphene Oxide Insertion Layer
Authors: Li-Wen Wang , Chih-Wei Huang , Ke-Jing Lee , Sheng-Yuan Chu , Yeong-Her Wang
Published: May 2023

Recently, resistive random access memory (RRAM) has been an outstanding candidate among various emerging nonvolatile memories for high density storage and in-memory computing applications. However, the traditional RRAM, which accommodates two states depending on applied voltage, cannot meet the high density requirement in the era of big data. Many research groups have demonstrated that RRAM possesses the possibility of multi-level cell to overcome the demand of mass storage. Among numerous semiconductor materials, gallium oxide, as the fourth-generation semiconductor material, is highly-profile due to its excellent material proper-ties, and already be widely used in optoelectronics, high-power, resistive switching device and so on, due to its wide bandgap and transparent properties. In this study, we have successfully demonstrated the Al/GO/Ga2O3/ITO RRAM to achieve the possibility of two-bit storage. Compared to the single-layer counterpart, the bilayer structure has excellent electrical properties and stable reliability. The endurance characteristics could be enhanced above 100 switching cycles with an ON/OFF ratio of over 103. Moreover, the filament models are also described in this thesis to clarify the transport mechanisms.
Evaluation of Implant Stability Measurements According to Implant Placement Site and Duration in Elderly Patients: A Prospective Multi-Center Clinical Study
Authors: SHIM JI-SUK , KIM MOON-YOUNG , AN SE-JUN , KANG EUN-SUNG , CHOI YU-SUNG
Published: May 2023

As medical care aiming to maintain the quality of life for elderly patients is increases, implant treatment for elderly patients is increasing worldwide. Therefore, we aimed to investigate implant stability and the reliability of different measuring devices according to implant placement site and duration in patients aged over 65 years.
The study evaluated 60 implants in 60 patients aged ≥ 65 years. The implant placement sites were divided into six evenly distributed sections (n=10) i.e., maxillary right- posterior, A; maxillary anterior, B; maxillary left-posterior, C; mandibular right-posterior, D; mandibular anterior, E; mandibular left-posterior, F. Participants visited the hospital seven times: preoperatively, 1V; implant surgery, 2V; stitch removal, 3V; 1-month follow-up, 4V; 2-months follow-up, 5V; before final-restoration delivery, 6V; and after final-restoration delivery, 7V. The implant stability was evaluated with the Osstell Mentor (ISQ), Periotest M (PTV), and Anycheck (IST). The mean values of ISQ, PTV, and IST were analyzed (α=.05).
ISQ, PTV, and IST results of 5V and 6V were significantly higher than those of 2V (P<.05). The lowest ISQ results occurred in E location at 5V and 6V (P<.05). In all mandibular locations, IST results of 7V were significantly higher than those of 2V, 3V, 4V, and 5V (P<.05). ISQ results were negatively correlated with PTV and positively correlated with IST, and PTV was negatively correlated with IST.
By considering various factors that affect implant stability, the appropriate implant load application time was determined. This could help increase the implant success rate in elderly patients. And as a diagnostic device for implant stability for evaluation of osseointegration in elderly patients, Anycheck was also able to prove its relative reliability compared to Osstell ISQ Mentor and Periotest M.
Estimating Value at Risk From Implied Volatilities Using Machine Learning Meth-Ods and Quantile Regression
Authors: Blom Herman Mørkved , De Lange Petter , Risstad Morten
Published: May 2023

In this study we propose a semi-parametric, parsimonious Value at Risk forecasting model, based on quantile regression and machine learning methods, combined with readily available market prices of option contracts from the over-the-counter foreign exchange rate interbank market. We aim at improving existing methods for VaR prediction of currency investments using machine learning. We employ two different methods - ensemble methods and neural networks.

Explanatory variables are implied volatilities with plausible economic interpretation. The forward-looking nature of the model, achieved by the application of implied volatilities as risk factors, ensures that new information is rapidly reflected in Value at Risk estimates. To the best of our knowledge, this paper is the first to utilize information in the volatility surface, combined with machine learning and quantile regression, for VaR prediction of currency investments.

The proposed ensemble models achieve good estimates across all quantiles. The light gra-dient-boosting machine model and the categorical boosting model both yield estimates which are better than, or equal to, those of the benchmark model. The neural network models are in general quite unstable.
Multilineage-Differentiating Stress-Enduring Cells (Muse Cells): An Easily Accessible, Pluripotent Stem Cell Niche with Unique and Powerful Properties for Multiple Regenerative Medicine Applications
Authors: Ossanna Riccardo , Veronese Sheila , Quintero Sierra Lindsey Alejandra , Conti Anita , Conti Giamaica , Sbarbati Andrea
Published: May 2023

Cell-based therapy in regenerative medicine is a powerful tool that can be used both to restore various cell lost in a wide range of human disorders, and in renewal processes. Stem cells show promise for universal use in clinical medicine, potentially enabling the regeneration of numerous organs and tissues in the human body. This is possible due to their self-renewal capacity, and their ability to differentiate into various cell types. To date, pluripotent stem cells seem to be the most promising regeneration tool. Recently, a novel stem cell niche, called multilineage-differentiating stress-enduring (Muse) cells, is emerging. These cells are of particular interest because they are pluripotent and are found in adult human mesenchymal tissues. One of their most significant features is that they can produce cells representative of all the three germ layers. Furthermore, they can be easily harvested from fat, and isolated from the mesenchymal stem cells. This makes them very promising, allowing autologous treatments and avoiding the problems of rejection, typical of transplants. Muse cells have recently been employed, with encouraging results, in numerous preclinical studies, performed to test their efficacy in the treatment of various pathologies, exploiting their regenerative potential in different tissues. This systematic review aimed to 1) highlight the specific potential of Muse cells, and provide a better understanding of this niche, and 2) originate the first organized review of already tested applications of Muse cells in regenerative medicine. The obtained results could be useful to extend the possible therapeutic applications of Muse cells.
Aging Disrupts Circadian Rhythms in Mouse Liver Mitochondria
Authors: Xu Wei , Li Xiaodong
Published: May 2023

The circadian clock regulates daily changes in behavioral, endocrine and metabolic activities in mammals. Circadian rhythms in cellular physiology are significantly affected by aging. In particular, we previously found that aging has profound impact on daily rhythms in mitochondrial functions, leading to increased oxidative stress. However, this is unlikely due to malfunction of molecular clocks in the suprachiasmatic nucleus or peripheral tissues, as robust clock oscillations are observed therein in old animals. Nonetheless, aging induces changes in gene expression levels and rhythms in various peripheral and probably central tissues. In this article, we review findings on the roles of the circadian clock and aging in regulating mitochondrial rhythms and redox homeostasis. Chronic sterile inflammation is implicated in mitochondrial dysfunction and increased oxidative stress during aging. In particular, upregulation of CD38 by inflammatory response can disturb mitochondrial functions in multiple ways.
Effect of Fish Oil and Linseed Oil on Intake, Milk Yield and Milk Fatty Acid Profile in Goats
Authors: Thanh Lam Phuoc , Loor Juan Jose , Mai Duong Tran Tuyet , Hang Tran Thi Thuy
Published: May 2023

This study aimed to evaluate the effect of incorporating linseed oil and fish oil in the diet on intake, ruminal fermentation milk yield and milk fatty acid profile in dairy goats. Four crossbred Saanen lactating goats in mid-lactation and milking 1.30±0.28 g/day were used in a 4 × 4 Latin square design. The basal diet consisted of concentrate and Para grass (C:F 40:60). Treatments included the basal diet without oil supplement (Ctrl) or with 2.5% linseed oil (LO2.5), 2.5% linseed oil and fish oil (3:2, w/w, LFO2.5), and 4.16% linseed oil and fish oil (3:2, w/w, LFO4.16). Diets had no effect on intake, milk yield, milk composition and ruminal fermentation patterns (P > 0.05). The lower (P < 0.05) proportions of C10:0-C14:0 in milk fat were observed with LFO4.16 compared with Ctrl. Compared with the Ctrl and linseed oil added alone, feeding LFO4.16 resulted in a 589% and 303% increase in C18:1 t11, respectively. Milk c9,t11 CLA was markedly increased with the LFO4.16 diet, accounting for 4.53 and 2.94 times greater concentrations than those in Ctrl and LO2.5 diets, respectively (P < 0.01). Goats fed LFO2.5 and LFO4.16 had greater levels of C22:6n-3 (0.63% and 0.87%; P < 0.001) compared with those fed Ctrl and LO2.5 diets (0.06% and 0.08%). Overall, the combined data suggested that including 4.16% linseed oil and fish oil in the diet of dairy goats is effective for improving the concentrations of healthy fatty acids in milk, without affecting milk production.
Route to Chaos in a Unidirectional Ring of Three Diffusively Coupled Erbium-Doped Fiber Lasers
Authors: Esqueda de la Torre José Octavio , García-López Juan Hugo , Jaimes-Reátegui Rider , Huerta-Cuellar Guillermo , Aboites Vicente , Pisarchik Alexander N.
Published: May 2023

We study the synchronous dynamics of three diffusively coupled erbium-doped fiber lasers (EDLFs) in the unidirectional ring configuration without external pump modulation. The dynamical behavior of the system is analyzed using time series, Fourier spectra, Poincaré sections, bifurcation diagrams, and Lyapunov exponents for different values of the coupling strength. For weak coupling, we observe a well-known route to chaos from a stable equilibrium through a Hopf bifurcation and a series of torus bifurcations as the coupling strength is increased. An interesting result is found for large values of the coupling strength, where the phase locking is close to zero. This allows a significant increase in the peak energy of the EDFLs pulses, i.e., above the coupling strength the lasers switch to a Q-switching mode with large-amplitude short pulses. This result allows us to propose a new method for increasing the laser pulse energy based on the control of the bistability by the rotating wave in the array of three unidirectionally ring-coupled EDFLs as a function of the coupling strength. In our system, we were able to increase the peak laser power by almost 20 times more than a continuous single EDFL.