bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical Utility of Genetic Testing in the Precision Diagnosis and Management of Pediatric Patients with Kidney and Urinary Tract Diseases
Authors: Bekheirnia Nasim , Glinton Kevin E. , Rossetti Linda , Manor Joshua , Chen Wuyan , Lamb Dolores J. , Braun Michael C. , Bekheirnia Mir Reza
Published: October 2020

Background

As genetic testing increasingly integrates into the practice of nephrology, our understanding of the basis of many kidney disorders has exponentially increased. Given this, we recently initiated a Renal Genetics Clinic (RGC) at our large, urban children’s hospital for patients with kidney disorders.

Methods

Genetic testing was performed in Clinical Laboratory Improvement Amendments–certified laboratories using single gene testing, multigene panels, chromosomal microarray, or exome sequencing.

Results

A total of 192 patients were evaluated in this clinic, with cystic kidney disease (49/192) being the most common reason for referral, followed by congenital anomalies of the kidney and urinary tract (41/192) and hematuria (38/192). Genetic testing was performed for 158 patients, with an overall diagnostic yield of 81 out of 158 (51%). In the 16 out of 81 (20%) of patients who reached a genetic diagnosis, medical or surgical treatment of the patients were affected, and previous clinical diagnoses were changed to more accurate genetic diagnoses in 12 of 81 (15%) patients.

Conclusions

Our genetic testing provided an accurate diagnosis for children and, in some cases, led to further diagnoses in seemingly asymptomatic family members and changes to overall medical management. Genetic testing, as facilitated by such a specialized clinical setting, thus appears to have clear utility in the diagnosis and counseling of patients with a wide range of kidney manifestations.
La estela CG 20517 del rey Senaaib: un estudio de los problemas para su interpretación
Authors: Salem Leila
Published: October 2020

El presente artículo consiste en la primera publicación completa y detallada de la estela del rey Senaaib, estela de adoración al dios Min-Horus-nakht (CG20517) encontrada en Abidos y que actualmente es custodiada por el Museo de Antigüedades Egipcias de El Cairo. Proponemos una discusión acerca de la posible datación de la estela y la ubicación del faraón dentro de la cronología dinástica del antiguo Egipto. A su vez, realizaremos la transliteración y traducción completa de sus textos –primera versión en lengua española–, y una descripción y análisis detallado de su iconografía y de los problemas derivados de las inscripciones y traducción de sus textos. Además, incluiremos diferentes debates y argumentos, muchos de ellos contradictorios, planteados por los especialistas para interpretar la estela, proponiendo nuevos interrogantes a partir de una mirada interpretativa integradora de las perspectivas de análisis.
La investigación sobre el Antiguo Egipto en Brasil: balance, retos y perspectivas
Authors: Vasques Marcia Severina
Published: October 2020

Nuestro objetivo en este artículo es explicar el surgimiento de la Egiptología en Brasil, sus caminos de investigación, desdoblamientos e investigaciones futuras. Los estudios realizados en el campo de la Egiptología tuvieron como foco original a la familia imperial brasileña, lo cual demostró interés por los artefactos egipcios en la época en que era común la práctica del coleccionismo y nacían las ciencias del siglo XIX. Como resultado de dicho interés, los primeros objetos del Antiguo Egipto llegaron a Río de Janeiro y fueron depositados en el Museo Nacional de la Quinta da Boa Vista. Otro foco de estudio se originó en la Universidad de São Paulo, por estar situada en la ciudad que constituye el polo económico de Brasil y en la cual se realiza la mayor inversión en el área de la investigación científica. En nuestra opinión, es posible trazar una genealogía de la Egiptología brasileña a partir de dos ejes: Río de Janeiro, con el Museo Nacional y la Universidad Federal Fluminense y la Universidad de São Paulo. Fue a partir de estos centros formadores de investigadores que el área de la Egiptología se expandió hacia otras regiones del país.
Grafen Kaplı Kimyasal Sensörlerin Şişme Davranışları ve Matematiksel Modelleme
Authors: ÇELİK Sibel , BÜYÜKKABASAKAL Kemal , DENİZ Ali , AÇIKBAŞ Yaser , ÇAPAN Rifat , ERDOĞAN Matem
Published: October 2020

Bu çalışmada, grafen kaplı Langmuir-Blodgett (LB) ince filmlerin şişme davranışları Kuartz Kristal Mikrobalans (KKM) tekniği kullanılarak incelenmiştir. Bu filmler, bazı organik buharların (aseton, etanol ve metanol) difüzyon katsayı değerlerinin hesaplanması (Fick’in erken-zaman difüzyon kanunu kullanılarak) için oda sıcaklığında etkileşmeye bırakılmıştır. Difüzyon katsayı değerleri sırası ile aseton, etanol ve metanol için 20.43 x 10−16, 1.30 x 10−16 ve 0.91 x 10−16 cm2 s−1 olarak hesaplanmıştır. Benzer sıralama grafen kaplı KKM sensörünün tepkisi (frekans değişimi, Δf) için de aseton (342 Hz) > etanol (76 Hz) > metanol (51 Hz) olarak elde edilmiştir.
Etograma y análisis de los sonidos realizados por los machos durante la cópula en Colletes musculus (Friese) (Hymenoptera: Colletidae)
Authors: Chiappa Elizabeth , Mandujano Víctor
Published: October 2020

En el presente estudio se describe el comportamiento de cópula de los machos de Colletes musculus (Friese). Se analizan los sonidos producidos por ellos mediante vibración de las alas durante el apareamiento. Reevaluamos la conducta reproductiva en machos de C. musculus, basándonos en el análisis de las interacciones de los comportamientos reproductivos filmados en una población del sur de Chile. Las vibraciones que producen los machos durante la cópula podrían servir para cambiar la receptividad de las hembras. Se describen las conductas registradas antes, durante y después de la cópula las que se representan en un etograma, que resume el comportamiento de cópula de los machos.
Distribución de las especies de Epitragini (Coleoptera: Tenebrionidae) en Perú
Authors: Giraldo-Mendoza Alfredo
Published: October 2020

La distribución de la tribu Epitragini en Perú se actualiza a partir de la revisión de colecciones entomológicas peruanas y la recopilación de registros previamente publicados. Se presentan nuevos registros y preferencias de hábitat para ocho especies de los géneros Epitragopsis, Parepitragus y Phytophilus. También se proporcionan registros disponibles para cinco especies que no han sido halladas en colecciones peruanas y mapas de distribución.
La discriminación lingüística en estudiantes de bilingüismo de nativa.
Authors: Aguilar Mescco Luisa Nataly , Durand Gómez Emma Lourdes , Vilca Rodríguez Mauricio
Published: October 2020

El trabajo de investigación se desarrolló en el Instituto de Educación Superior Pedagógico Público de Arequipa, con el propósito de analizar, en primer lugar, si existe discriminación lingüística hacia los bilingües de nativa y, en segundo término, conocer cuáles son las formas de tal exclusión. Para la operacionalización de variables se consideró las siguientes dimensiones: bilingüismo de nativa (quechua-castellano; aimara-castellano) y cuatro formas de discriminación lingüística. El tipo de investigación es descriptiva, de diseño ex-post-facto, desarrollada bajo el enfoque cuantitativo. Se utilizó la encuesta y un cuestionario de 21 preguntas para el recojo de información; con estos materiales pudimos obtener datos respecto de las diferentes formas de discriminación lingüística hacia los bilingües nativos quechua-aimaras, dentro de la institución en mención. La población está constituida por el 100% de los estudiantes del IESPPA. Las conclusiones evidencian la existencia de discriminación lingüística hacia los bilingües de nativa, debido a que la mayoría de ellos aún no tiene claro las variedades lingüísticas y que en nuestro medio persiste el prejuicio de que hay una sola norma estándar, que se presenta como única y válida y esta se debe aplicar en todas las situaciones y contextos comunicativos.
Evaluación de la eficacia de la guía quirúrgica ROGA y la técnica a mano alzada en el posicionamiento tridimensional del implante en pacientes del Centro Odontológico de la Universidad Católica de Santa María de Arequipa 2019.
Authors: Gamarra Ojeda Roxana , Cáceres Huambo Alberto
Published: October 2020

El éxito de una rehabilitación sobre implantes radica en el correcto posicionamiento tridimensional del implante y una guía quirúrgica que ha sido previamente planeada con un protocolo reveso nos acerca a ese objetivo; se crea la guía quirúrgica ROGA que pretende ser más eficaz que la técnica a mano alzada en dicho posicionamiento; para evaluarla se colocó 8 implantes con Guía ROGA y 8 implantes a mano alzada, y luego se evaluó el posicionamiento tridimensional utilizando las tomografías del antes y después, se evaluaron 5 medidas, mesiodistal y vestíbulo palatina ambas a nivel coronal y a nivel apical y la ápicocoronal; los implantes colocados con la guía ROGA no tuvieron ninguna desviación a nivel mesiodistal coronal y en las demás medidas tuvieron menos desviaciones con relación a la planificación reversa con una media de 0,457mm a diferencia de la de mano alzada que tuvo una desviación media de hasta 1,91 mm; se encontró diferencia estadísticamente significativo en las demás medidas no hubo diferencia estadísticamente significativo. Sin embargo, en implantes una pequeña desviación milimétrica puede afectar el tratamiento rehabilitador. Se concluyó que la guía ROGA es más eficaz en el posicionamiento tridimensional del implante dental.
CAD/CAM system implementation criteria in the process generating
of optimal and efficient models for clothing industry
Authors: DIMITRIJEVIĆ DRAGAN , SPAIĆ OBRAD , ĐURIĆ ŽELJKO , UROŠEVIĆ SNEŽANA , NIKOLIĆ MAJA
Published: October 2020

The first part of the paper is a systematic explanation of the process of defining the most important parameters for
generating optimal and efficient models of small and medium sized enterprises (SMEs) of the clothing industry, with the
presentation of specific and adequate methods of research, i.e. with the evaluation of data for designing new models,
and including previous research data. The following is an explanation of the final phase, i.e. a systematic and objective
design assessment, through the implementation of preliminary results of exploitation studies of the modal experiment
and computer simulation of the new model, based on which the criteria for efficient and optimal implementation of the
CAD/CAM systems are defined.
Multivariate analysis of the 3D composites based on nickel microparticles
Authors: Aileni Raluca Maria , Chiriac Laura , Albici Silvia , Sandulache Irina Mariana , Neagu Valeria , Raducu Liliana
Published: October 2020

This paper presents multivariate analyses of the experimental parameters obtained in the scientific experiments on eight
sample fabrics of 100% cotton with electrically conductive properties and electromagnetic achieved through traditional
treatments such as padding with antistatic agents, and direct printing or scraping with a polymeric paste based on nickel
(Ni). Textile printing was obtained using polymers such as polyethylene glycol (PEG), polyvinyl alcohol (PVA),
polyacrylate, ammonium salt, carboxylic acid Copolymer polyester, and Ni microparticles. For the eight samples that
have been analyzed, the morphology of the surfaces using SEM (scanning electron microscope) with magnification
2000–8000x and electronic magnification microscopy with 4x, assessed the resistance to wet rubbing and dry the
resistance of the surface after treatment in the solution of alkaline and acid sweat. Also, the samples above referred
have been analyzed by spectrophotometry to evaluate the transmittance, and reflectance of the electromagnetic waves.
It can specify that after treatments in acid or alkaline sweat solutions, the resistance of the surface has decreased by
103–105. It has been observed that for samples treated with acid or alkaline sweat, the reflectance was increased in
comparison with the reflectance obtained for the original samples. The multivariate analysis provided refers to the study
of some physic-chemical and optical parameters, of the samples collected, such as thickness, pH, reflectance, and
transmittance
CASE-BASED REASONING PEMILIHAN METODE KONSTRUKSI JALAN DI ATAS TANAH BERMASALAH KEDALAMAN 10 SAMPAI DENGAN 20 METER
Authors: Iqbal Maulana , Soekiman Anton
Published: October 2020

Permasalahan konstruksi jalan di atas tanah bermasalah (problematic soil) tanpa adanya perbaikan  tanah (soil improvement) maupun perkuatan tanah (soil reinforcement), pada umumnya akan mengakibatkan instabilitas timbunan dan penurunan tanah dasar. Tidak sedikit jaringan jalan di atas tanah dasar bermasalah di beberapa area di Indonesia mengalami penurunan tingkat pelayanan yang drastis sebelum umur rencana. Kurangnya pemahaman karakteristik tanah dasar menyebabkan pemilihan metode konstruksi tidak efektif dan efisien. Kecenderungan pemilihan metode yang digunakan masih didasari ketersediaan pagu anggaran. Pemilihan metode konstruksi jalan di atas tanah dasar bermasalah dengan analisis Case-Based Reasoning (CBR), dapat menghemat waktu dalam pengambilan keputusan berdasarkan keahlian pakar, sehingga risiko ketidakakuratan pemilihan metode berakibat pada keputusan penanganan yang kurang tepat dapat diminimalisir. Berdasarkan hasil analisis dengan mengambil studi kasus tol Pemalang – Batang pada kedalaman tanah bermasalah antara 10 sampai dengan 20 meter dan menggunakan analisis CBR, didapatkan  gejala kecocokan (similarity) sebesar 97,74% pada metode Prefabricated Vertical Drain (PVD) yang dikombinasikan dengan metode pembebanan dengan vakum (vacuum preloading) dan Prefabricated Horizontal Drain (PHD).
EVALUASI KINERJA DAN ANALISIS TINGKAT KEPUASAN PENUMPANG DI STASIUN KRL GROGOL
Authors: Purba Jessica Paulina , Sari Christina , Rintawati Dewi
Published: October 2020

Stasiun Grogol merupakan Stasiun KRL Commuter Line yang terletak di Jalan Prof. Dr. Latumenten, Jelambar, Jakarta Barat. Stasiun ini termasuk ke dalam stasiun kelas kecil dan baru diaktifkan pada bulan Juni 2015, namun peningkatan jumlah penumpang terjadi setiap tahunnya. Hal ini menandakan bahwa Stasiun Grogol memiliki potensi untuk lebih dikembangkan, didukung dengan lokasi yang strategis sehingga banyak penumpang yang menggunakan KRL Commuter Line di stasiun ini. Oleh karena itu penelitian ini bertujuan untuk mengevaluasi kinerja pelayanan dan fasilitas di Stasiun Grogol, dan menganalisis tingkat kepuasan penumpang terhadap pelayanan dan fasilitas yang telah diberikan. Penelitian ini dilakukan dengan observasi secara langsung untuk mengevaluasi kinerja pelayanan dan fasilitas di Stasiun Grogol yang akan dibandingkan dengan Standar Pelayanan Minimum pada PM 63 Tahun 2019. Selain itu dilakukan penyebaran kuesioner untuk menganalisis tingkat kepuasan penumpang terhadap pelayanan dan fasilitas yang telah diberikan. Hasil dari kuesioner akan melalui uji validitas dan uji reliabilitas, kemudian diolah menggunakan metode Importance Performance Analysis (IPA). Berdasarkan hasil evaluasi, Stasiun Grogol telah memenuhi 78,72% tolok ukur yang terdapat pada PM 63 Tahun 2019. Dari hasil analisis tingkat kepuasan penumpang diperoleh nilai rata-rata tingkat kesesuaian yang masih di bawah 100%, yaitu 77,07%. Artinya secara keseluruhan kinerja pelayanan dan fasilitas di Stasiun Grogol masih belum sesuai dengan yang diharapkan, sehingga belum memenuhi kepuasan penumpang. Hal ini dapat dilihat dari posisi atribut yang masih berada di kuadran A dan kuadran C yang memerlukan penanganan untuk ditingkatkan lagi kinerjanya.
A TERAPIA COGNITIVA COMPORTAMENTAL
Authors: Medeiros Julia Vidal
Published: October 2020

A violência sexual infantil é um importante problema de saúde pública no Brasil. Dados apontam maior incidência no próprio ambiente intrafamiliar, com relação de vínculo afetivo entre o agredido(a) e o ofensor sexual. Assim, o presente trabalho teve como objetivo compreender o que leva os indivíduos ofenderem sexualmente crianças do mesmo contexto familiar segundo a terapia cognitivo comportamental. Constituiu-se de uma revisão da literatura de produções científicas publicadas de 2008 a 2018, nas principais bases de dados nacionais. Os dados mostraram que a maioria dos ofensores são do sexo masculino, adulto, com laços de confiança e cuidado com a vítima. Com motivações ligadas à manifestação de fantasias sexuais, distorções cognitivas e comportamento impulsivo frente a estresse psíquico, devido a possíveis causas biológicas, temperamentais e ambientais. São necessárias intervenções multidisciplinares com foco na abordagem cognitiva comportamental.
ATUAÇÃO DO ENFERMEIRO APÓS DIAGNÓSTICO DE SÍFILIS NO PRÉ-NATAL DE BAIXO RISCO
Authors: Hora Aline , Machado Santos Emanuelle , Dias da Cruz Karolânia , Kelly Fraga Oliveira Fernanda , Shuamme Bento Fraga Adhara , Oliveira Melo Prado Lourivânia , Silveira Almeida Ândria
Published: October 2020

Compreender a atuação do enfermeiro no atendimento a gestantes diagnosticadas com sífilis durante o pré-natal de baixo risco. Método: trata-se de um estudo bibliográfico, descritivo com abordagem qualitativa. Realizou-se levantamento bibliográfico nas bases de dados Scientific Electronic Library Online (SciELO), Base de dados de Enfermagem (BDENF), Publicações Bibliográficas Médicas (PubMed) e MEDLINE, utilizando o operador booleano AND. Foram incluídos na presente pesquisa artigos entre os anos de 2014 e 2018, abordando a temática sobre o cuidado do enfermeiro com gestantes diagnosticadas com sífilis na Atenção Primária à Saúde, on-line, gratuitos e nos idiomas português e inglês e excluídos os artigos que não contemplaram a temática. Resultados: identificou-se que os profissionais em sua maioria possuem o preparo ideal para o cuidado da gestante diante de um resultado positivo para sífilis, porém concordam que ainda há profissionais carentes de conhecimento e que a busca constante por conhecimento é o caminho para uma melhor conduta e, consequentemente, melhoria do cuidado as gestantes. Conclusão: observa-se que o enfermeiro tem papel fundamental no combate a sífilis principalmente, no pré-natal, impedindo agravos ao bebê, como observa-se também, que esse profissional tem se mostrado cada vez mais preparado.
Optical data transmission at 44 Terabits/s with a 49GHz Kerr soliton crystal microcomb
Authors: Moss David
Published: October 2020

We
report world record high data transmission over standard optical fiber from a
single optical source. We achieve a line rate of 44.2 Terabits per second
(Tb/s) employing only the C-band at 1550nm, resulting in a spectral efficiency of
10.4 bits/s/Hz. We use a new and powerful class of micro-comb called soliton
crystals that exhibit robust operation and stable generation as well as a high
intrinsic efficiency that, together with an extremely low spacing of 48.9 GHz
enables a very high coherent data modulation format of 64 QAM. We achieve error
free transmission across 75 km of standard optical fiber in the lab and over a
field trial with a metropolitan optical fiber network. This work demonstrates
the ability of optical micro-combs to exceed other approaches in performance
for the most demanding practical optical communications applications.
A novel approach for fast and effective influence spread maximization in social networks
Authors: Scarabaggio Paolo , Carli Raffaele , Dotoli Mariagrazia
Published: October 2020

The main characteristic of social networks is their ability to quickly spread information between a large group of people. This phenomenon is generated by the social influence that individuals induce on each other.
The widespread use of online social networks (e.g., Facebook) increases researchers' interest in how influence propagates through these networks. One of the most important research issues in this field is the so-called influence maximization problem, which essentially consists in selecting the most influential users (i.e., those who are able to maximize the spread of influence through the social network).
Due to its practical importance in various applications (e.g., viral marketing, target advertisement, personalized recommendation), such a problem has been studied in several variants. Different solution methodologies have been proposed. Nevertheless, the current open challenge in the resolution of the influence maximization problem still concerns achieving a good trade-off between accuracy and computational time.
In this context, based on the well-known independent cascade and the linear threshold models of social networks, we propose a novel low-complexity and highly accurate algorithm for selecting an initial group of nodes to maximize the spread of influence in large-scale networks. In particular, the key idea consists in iteratively removing the overlap of influence spread induced by different seed nodes. Application to several numerical experiments based on real datasets proves that the proposed algorithm effectively finds practical near-optimal solutions of the addressed influence maximization problem in a computationally efficient fashion. Finally, comparison with the best performing state of the art algorithms demonstrates that in large scale scenarios, the proposed approach shows higher performance in terms of influence spread and running time.
Perangkat Lunak Pengelolaan Surat Di Kecamatan Lengkong
Authors: Hamdani Deden Sofyan
Published: October 2020

Negara yang berkembang membuat informasi yang dibutuhkan semakin mudah untuk didapatkan, hal ini dapat dilihat dari meningkatnya dan berkembangnya kebutuhan masyarakat, perusahaan dan juga instansi pemerintahan dalam mendapatkan data dan informasi. Seperti halnya kantor Kecamatan Lengkong Kota Bandung merupakan salah satu instansi pemerintahan dalam menjalankan roda pemerintahannya membutuhkan sistem informasi yang telah terkomputerisasi dengan baik. Sistem informasi yang dibutuhkan oleh kantor Kecamatan Lengkong Kota Bandung yang dapat menangani pengolahan dan penyampaian informasi mengenai data-data surat. Perangkat Lunak ini merupakan aplikasi berbasis desktop untuk memudahkan setiap pegawai di Kecamatan Lengkong dalam memelihara arsipnya. Untuk merancang sebuah desktop, maka di perlukan tahapan perancangan dengan menggunakan model prototype, dan tools yang di gunakan untuk merancang sebuah dekstop menggunakan Star UML. Bahasa pemograman yang di gunakan untuk membuat desktop ini dengan menggunakan bahasa pemograman Visual Basic, dan database-nya MySQL. Pada Akhirnya, Perangkat Lunak Pengelolaan Surat di Kecamatan Lengkong ini dapat ditarik kesimpulan bahwa perangkat lunak ini memberi kemudahan pada semua pegawai dalam memelihara arsip yang ada dalam perusahaan, Dan dapat dengan mudah mengakses arsip saat diperlukan
La metafísica de la creación de Duns Escoto: el entendimiento divino como locus de los posibles
Authors: Larre Olga
Published: October 2020

La exhaustiva bibliografía escotista de Tobías Hoffman registra unos pocos estudios comparativos entre Escoto y Leibniz marcando el carácter exiguo de los antecedentes contemporáneos sobre trabajos que desarrollen esta línea de indagación.
Nuestro interés consiste en poner las bases de una investigación que evidencie las estrategias argumentativas puestas en juego en la configuración de las metafísicas de la creación propuestas por ambos pensadores.
En este contexto y como primera aproximación, nuestro artículo se centra en Escoto y describe la analítica de la creación con las distintas mediaciones sugeridas en el ámbito de la inteligencia y de la voluntad. En primer lugar, nos detenemos en la fenomenología del conocimiento divino que da origen a los posibles. Escoto distingue dos órdenes de posibilidad: la formal y la ontológica. La primera proviene de la relación de compatibilidad y no contradicción entre las formalidades constitutivas de lo posible. La ontológica reconoce como causa al entendimiento divino en cuanto es principio del esse inteligibile. El entendimiento divino aparece como región de los posibles a los que la existencia no les pertenece ni les repugna esencialmente.
En un segundo momento se analiza el paso a la existencia de los posibles como efectos de la acción libre y contingente de la voluntad omnipotente de Dios bajo la modalidad de una causalidad sincrónica.
Oposições dialéticas do phármakon no Fedro de Platão
Authors: Fortes Fabio
Published: October 2020

Tendo como ponto de partida a ambiguidade contida na metáfora do phármakonassociada à escrita no Fedrode Platão, neste artigo pretendemos examinar os demais contextos em que essa palavra aparece nesse diálogo. Nosso objetivo é compreender o emprego da metáfora farmacológica para a determinação da escrita, e do modo como as diferentes oposições que ela engendra colaboram para compreender o movimento dialético. Por meio da explicação dessas contraposições, pretendemos mostrar que as palavras escritas em Platãoestão permanentemente sujeitas a um renversementde sentidos, e que o fruto dessas disassociações e congruências constitui exemplificação da própria dialética. Para isso, consideramos também a leitura que Derrida (2004 [1972]) faz da passagem, mas a transcendemos na medida em que, ao considerarmos as diferentes oposições dialéticas contidas no diálogo, não vislumbrarmos, como efeito do phármakonplatônico, uma centralidade da escrita (ou da oralidade) para Platão.
Pros-Cons of Implementing the Right to be Forgotten Rules in the ITE Law
Authors: Saharuddin Saharuddin
Published: October 2020

Article 26 paragraph (3) of Law number 19 the Year 2016 concerning Electronic Information and Transactions (The ITE Law) in Indonesian concerning the right to be forgotten. The contents of this article allow a person based on a court order to ask the electronic system administrator to delete irrelevant electronic information that is under their control. This provision conflicts with several other rights, which are also regulated in several laws. Like the location of the intersection right to be forgotten with the protection of personal data and public access to information.
МЕТОДИКА ДИАГНОСТИКИ СОСТОЯНИЯ МАГИСТРАЛЬНОГО ГАЗОПРОВОДА
Authors: Габибов Ибрагим
Published: October 2020

Maqistral qazkəmərlərinə qaz axınının hidravlik müqavimət əmsalı artmasına ən çox təsir edən faktorlar sırasıda hidrat tıxacları və kondensatın əmələ gəlməsi, borunun diametrinin istismar prosesində dəyişməsi və son olaraq kəmərinin tıxanmasına səbəb olan qum amili səbəb olur. Məqalədə qəzaları aşkar etmək üçün onların ardıcıl əmələgəlmə metodlardan istifadə edərək magistral qaz kəmərinin vəziyyətinin öyrənilməsinə həsr edilmişdir. Açar sözlər: magistral boru kəmərləri, hidravlik müqavimət əmsalı, hidrat tıxacları, stasionar rejim, imtinalar.
Complicações e desfechos clínicos de pacientes em uso de nutrição parenteral em um hospital público do Distrito Federal
Authors: Granjeiro Mayra de Lima , Borges Sheila , Fortes Renata Costa
Published: October 2020

Introduction: Parenteral nutrition has become an effective alternative for caloric-protein supply in hospitalized patients. The objective of this study is to evaluate the use, complications and clinical outcomes of patients using parenteral nutrition. Methods: Analytical, quantitative, longitudinal, retrospective study with patients admitted to a public hospital. The variables analyzed were: sex, age, presence of malnutrition, nutritional risk, achievement of nutritional goals, reason for indication, type of access, time of use, present complications and deaths. Results: The sample consisted
of 62 patients aged 55.1±17.95 years old. Total parenteral nutrition was found more frequently (61%; n=38) and used within 30 days (74%; n=28). As indicated, the postoperative period was prevalent in 45.2% (n=28) of the cases. Nutritional risk (58.1%, n=36) and malnutrition (40.3%; n=25) were prevalent. Hyperglycemia (50%; n=31) and water retention (48.4%; n=30) were the most frequent complications. The presence of water retention increased the chances of death by 3.75 times (OR=3.75; 95%IC 1.25-11.24; p=0.018). Conclusion: The indication of parenteral nutrition was prevalent in postoperative situations, in patients with nutritional risk and malnutrition. Hyperglycemia was the most observed complication and the presence of water retention associated with a higher risk of mortality when using this therapy.
Comportamento alimentar e alterações sensoriais em pacientes em quimioterapia
Authors: Fernandes Otávio Augusto Moura , Casari Larissa , da Silva Vera Lúcia Ferreira Vera Lúcia Ferreira , Goularte Laura Moreira , de Oliveira Shirley Sousa , d’Almeida Karina Sanches Machado , Marques Anne y Castro
Published: October 2020

Introduction: Chemotherapy is a type of treatment widely used against cancer, but it can result in sensory changes and aversion to foods usually consumed before treatment, negatively impacting the patient’s nutritional status. The objective of this study was to assess the feeding behavior and the possible changes of taste and smell in patients undergoing chemotherapy at the Hospital School of Universidade Federal de Pelotas (UFPel). Methods: A cross-sectional study was conducted in the first half of 2019, with patients above 18 years, in the second cycle of chemotherapy. The data
collection was performed from a self-administered questionnaire containing sociodemographic and treatment-related information, presence of signs and symptoms, and acquired food aversion. Data were analyzed using descriptive analysis, and to compare categorical variables between the moments before and after chemotherapy, Pearson’s chi-square test was used, with p <0.001. Results: A total of 101 cancer patients participated in the study, most of them female (58.4%). The initial tumor sites of higher prevalence were in the gastrointestinal tract and in the breast.
Foods that showed statistically altered dietary pattern (p<0.001) were: beans, leafy vegetables, vegetables, milk and dairy products, bread/cakes, soups, soft drinks/sweet drinks. Regarding the food aversion seized, the food that stood out the most was soft drinks/sweets and processed meat. The most frequently cited adverse effects of the treatment were: alteration or reduction in the taste of food, xerostomia and nausea caused by the food’s aroma. Conclusion: Chemotherapy affects the patient’s relationship to food, causing an important change in eating behavior.
Terapia Nutricional Enteral Domiciliar em tempos de isolamento social devido à pandemia de COVID-19
Authors: dos Santos Emilaine Ferreira , Rabito Estela Iraci , Mazur Caryna Eurich , Thieme Rubia Daniela , Schieferdecker Maria Eliana Madalozzo
Published: October 2020

Home enteral nutrition (HEN) provides care for the special need for food at home. Although the majority of patients in HEN is clinically stable, support from health professionals, and monitoring and evaluation for maintenance or evolution of therapy are necessary. However, the current pandemic situation of COVID-19 and the lack of specific treatment for coronavirus infection have led to changes in the health services work routine. The social distance recommendation to contain the progress of COVID-19 interferes with the home care service. Thus, in order to provide assistance effectively and safely to the patient, family members and health professionals, adaptations can be made. Therefore, the objective of this manuscript is to discuss elements and recommendations that contribute to HEN care during the COVID-19 pandemic.
Novel approaches for the rational design of PROTAC linkers
Authors: Zagidullin Almaz , Milyukov Vasili , Rizvanov Albert , Bulatov Emil
Published: October 2020

Proteolysis targeting chimeras (PROTACs) represent a promising class of hetero-bivalent molecules that facilitate ubiquitination of a target protein by simultaneously binding and bringing together both the E3 enzyme and the target. These compounds consist of three structural components: two ligands one of which binds the protein of interest (POI) while the other binds an E3 ubiquitin ligase to promote POI ubiquitination, and a linker connecting both moieties. Recent developments in the field highlight the fact that linker composition and length play a crucial role in achieving optimal PROTAC properties, modulate binding kinetics and substantially impacts the potency and selectivity. In this review, the authors briefly discuss the recent findings in PROTAC design approaches with focus on the linker. For each PROTAC such linker parameters as chemical nature, length, hydrophilicity and rigidity have to be optimized to achieve improved stability, bioavailability cell membrane permeability and suitable spatial orientation between the target POI and the E3 ubiquitin ligase. Thus rational linker design with respect to composition, length and attachment sites is essential for the development of potent PROTAC compounds. Computer-aided design and novel innovative linker strategies, such as PROTAC shortening, photo-switchable PROTACs, in-cell click-formed CLIPTACs, “click chemistry” approaches are also discussed in the review.
Desenvolvimento de Ceraeochrysa cincta (Schneider, 1851) (Neuroptera: Chrysopidae) alimentada com dieta artificial na fase larval
Authors: Moller Hermann , Taguti Érica A. , Amorim Luis C. S. , Pinto Matheus M. D. , De Bortoli Sergio A.
Published: October 2020

Abstract. Mass production of lacewings is still a bottleneck for applied biological control and for biofactories producing natural enemies, due to the difficulties of large-scale production and the cost of the undertaking and the production of their alternative prey. Thus, the objective of this work was to evaluate the viability of an alternative artificial diet to rearing of Ceraeochrysa cincta (Schneider, 1851) (Neuroptera: Chrysopidae). Three treatments were analyzed for this purpose, consisting of: 1) natural diet - eggs of Corcyra cephalonica (Stainton, 1866) (Lepidoptera: Pyralidae), 2) artificial diet honey + beer yeast (1:1) and 3) natural diet (1) + artificial diet (2), and were offered to the larval stage of the predator. The biological parameters of C. cincta evaluated where: duration of larval, pupal and adult phases; pupal weight; pupal viability; sex ratio; pre-oviposition and oviposition periods and number of eggs per female. Were obtained adults only in the treatments 1 and 3 and, in the treatment 2 no insect reached the pupal stage. The results obtained demonstrated that the artificial diet, when offered in isolation, causes significant differences in the duration of the larval period, especially in the 3rd instar, and in the weight of the pupae, with the other similar parameters in the treatments, but can serve as a nutritional supplement.
The Teaching of the History and Problems of Instilling a Sense of Patriotism
Authors: Черныш А.М.
Published: October 2020

в статье обсуждается значение преподавания истории в высших учебных заведениях. Отмечается место и роль преподавания истории в воспитании патриотизма. Освещаются проблемы и точки зрения, связанные с этой проблематикой, даются рекомендации, показан опыт преподавания истории в Московском педагогическом государственном университете.

the article discusses the importance and significance of teaching his-tory in high school. The place and role of History in the upbringing of patriotism is noted. The problems and points of view related to this issue are highlighted, recom-mendations are given. Experience in teaching History at the Moscow State Pedagogical University is shown.
Religious Studies as an Attribute of Professional Competence of a Modern Teacher
Authors: Михайлова Л.Б.
Published: October 2020

статья посвящена проблеме формирования религиоведческой компетентности в системе государственного высшего педагогического образования. Автор обосновывает приоритетность религиоведческого подхода к изучению религии в светских школах и вузах в условиях современного постсекулярного общества. В качестве оптимальной дисциплины, формирующей профессиональные навыки работы в поликонфессиональной аудитории, рассматривается философское религиоведение с элементами теологического знания.

the article is devoted to the problem of formation of religious competence in public higher teacher education. This paper substantiates the priority of religious studies approach in teaching religions at secular schools and in institutions of higher education in today’s postsecular world. Philosophical religious studies with the elements of theological knowledge are considered as the discipline which forms professional skills in multiconfessional society.
"OK, Google, who am I?": Young People about Multiple Identities in Virtuality and Reality
Authors: Кривенькая М.А.
Published: October 2020

статья представляет анализ результатов анкетирования и исследовательско-проектных работ студентов, который отражает спектр отношения обучающейся молодежи к возможностям проявления множественности своей идентичности в разных средах и на разных уровнях. Анализ производится на семантическом, семиотическом и прагматическом уровнях. В статье обозначены зоны рисков, связанных с коммуникативным поведением в виртуальной реальности, акцентируется феномен так называемой «ускользающей социализации», сравниваются варианты группового и средового отождествления. Затрагиваются вопросы отношения студентов к экстремальности самовыражения в условиях прозрачности информационных маршрутов и осознания ими степени свободы и ответственности в условиях пограничья реального и виртуального пространства.

the article presents an analysis of the results of questionnaires and student research works, which reflects the spectrum of attitudes of the youth to the possibilities of manifestation of the multiplicity of their identities in different environments and at different levels. The analysis is carried out at the semantic, semiotic, and pragmatic level. The article identifies the risk zones associated with communicative behavior in virtual reality, emphasizes the phenomenon of the so-called “escaping socialization”, and compares the options for group and environmental identification. It touches on the students’ attitude to the extremes of self-expression in the conditions of information routes transparency and their awareness of the degree of both freedom and responsibility on the borderline of real and virtual space.
Features of Preparation of Teachers of Higher School: Flexible Management Technologies
Authors: Лебедев А.Н. , Бурукина О.А.
Published: October 2020

авторы рассматривают консерватизм вузовских образовательных программ в качестве одного из препятствий в подготовке потенциальных преподавателей университетов. Рассмотрены особенности подготовки педагогов высшей школы по направлениям социально-гуманитарного образования. Авторы презентуют результаты анкетирования магистрантов и аспирантов, свидетельствующие о дефиците прикладных знаний респондентов в области современных технологий, таких как Agile. Обоснованы предложения по интенсификации программ повышения квалификации преподавателей, насыщению образовательных программ вопросами применения современных технологий менеджмента.

the authors consider the conservatism of university educational programs as one of the obstacles in the preparation of potential university teachers.
The article discusses the features of training higher education teachers in the areas of social and humanitarian education. The authors present the results of a survey of undergraduates and graduate students, indicating a lack of applied knowledge of postgraduate and graduate students in the field of modern technologies such as Agile. The article substantiates the proposals on the intensification of teacher development programs,
the saturation of educational programs with the application of modern management technologies.
Development of Distance Learning in Russia (on the Example of FSES 3rdGeneration and Distance Learning Platforms)
Authors: Васильева В.В.
Published: October 2020

в статье рассматривается развитие дистанционного обучения в России через ФГОС 3 поколения и дистанционных образовательных платформ. Автором было проведено исследование среди студентов выпускных курсов университетов России.

the article deals with the development of distance learning in Russia through the 3rd generation FSES and distance learning platforms. The author has conducted a research among graduate courses of Russian universities.
The Ash Wednesday Supper: The Collapse of the Idea of the Humboldt’s University in the Information Age
Authors: Мартинкус П.П.
Published: October 2020

статья показывает, что развитие товарных отношений в образовании имеет негативные последствия, которые пытаются редуцировать с помощью обращения к идеям «немецкой модели» университета. Необходимо от «идеалистических» форм противодействия социально-экономическому тренду
перейти к борьбе за «нормализованные» трудовые отношения.

the article shows that the development of commodity relations in education has negative consequences, which some people are trying to reduce by resorting to the ideas of the «German model» of University. It is necessary to move from the «idealistic» forms of counteracting the socio-economic trend to the struggle for «normalized» labor relations.
CRM system as an Element of Modern Management
Authors: Демина С.А. , Лин С. , Лян Т.
Published: October 2020

по мнению авторов, чтобы сохранить конкурентные преимущества компаниям необходимо внедрять специализированные системы управления взаимодействия со своими клиентами – CRM-системы. В статье обоснована необходимость внедрения CRM-систем в торговых организациях. Помимо общепринятых методов стимулирования сбытовой деятельности, предприятиям необходимо использовать и прогрессивные формы, основанные на функциональных возможностях информационных систем.

according to the authors, to maintain competitive advantages, companies need to implement specialized systems for managing interaction with their customers – CRM systems. The article substantiates the need to implement CRM systems in commercial organizations. In addition to the generally accepted methods of stimulating sales activities, enterprises need to use progressive forms based on the functionality of information systems.
On the Issue of Civil and Patriotic Education in Modern Russia and European Countries
Authors: Яшина О.Н.
Published: October 2020

автор кратко освещает развитие патриотического воспитания в России, дает рекомендации по организации работы данного направления, освещает опыт педагогов по гражданскому образованию из ряда европейских стран.

the author writes about the development of patriotic education in Russia, gives recommendations on the organization of work of the civil-patriotic education, writes about the experience of teachers in this area of european countries.
Management Decisions in the Russian Military Education System: Socio-Humanitarian aspect (second half of the XIX – early XX centuries)
Authors: Половецкий С.Д.
Published: October 2020

в статье обосновывается объективная необходимость изменения системы управления военным образованием в рамках проведения военной реформы второй половины XIX века. Проводимые мероприятия опирались на достижения русской педагогической мысли и военной педагогики. Комплекс управленческих решений был теоретически обоснованным, проводился последовательно и поступательно, до достижения необходимого положительного результата. Решить масштабные и сложные задачи оптимизации процесса военного образования было бы невозможно без усиления внимания к социально-гуманитарным дисциплинам, преподаваемых в военно-учебных заведениях. Накопленный исторический опыт реализации принятых управленческих решений актуален и востребован в настоящее время.

the article substantiates the objective need to change the management system of military education in the framework of military reform in the second half of the XIX century. The events were based on the achievements of Russian pedagogical thought and military pedagogy. It is emphasized that the complex of management decisions was theoretically justified, carried out consistently and progressively, until the necessary positive result was achieved. It would be impossible to solve these large–scale and complex tasks of optimizing the process of military education without increasing attention to the social and humanitarian disciplines taught in military educational institutions. The accumulated historical experience of implementing management decisions is relevant and may be in demand at the present time.
Plaučių vėžio imunoterapija
Authors: Vagulienė Neringa
Published: October 2020

Imunoterapija – tai gydymo metodas, kurio metu siekiama panaudoti ir (arba) suaktyvinti imuninės sistemos veikimo mechanizmus ir taip naikinti piktybines ląsteles, sukėlusias ligą. Navikų imunoterapija nėra naujas gydymo metodas, tačiau mokslininkams ilgai nepavyko atkurti sergančiojo onkologine liga imuninio atsako. Tik pastaraisiais metais klinikiniai tyrimai nustatė imunoterapijos veiksmingumą ir, remiantis šiais duomenimis, galima daryti prielaidą, kad imunoterapija gali tapti pagrindiniu vėžio gydymo metodu.
Vaistas Relvar Ellipta, palyginus su įprastu gydymu, reikšmingai pagerino Salfordo plaučių tyrime dalyvavusių pacientų astmos kontrolę
Authors: Malakauskas Kęstutis
Published: October 2020

Salfordo plaučių tyrimas yra daugelyje bendrosios praktikos centrų atvirai atliktas atsitiktinių imčių kontroliuojamasis tyrimas. Tyrimo metu nustatyta, kad flutikazono furoato ir vilanterolio (Relvar Ellipta) deriniu 52 savaites gydytiems pacientams, sergantiems simptomine astma, buvo geresnė astmos kontrolė be dažnesnių sunkių nepageidaujamų reiškinių, palyginus su pacientais, tęsusiais įprastą gydymą.
Biologinio vaisto Mepolizumabo poveikis gyvenimo kokybei ir plaučių funkcijai sergant sunkia eozinofiline astma: MUSCA tyrimo duomenys
Authors: Kalinauskaitė-Žukauskė Virginija
Published: October 2020

Ilgalaikio astmos gydymo tikslas – pasiekti simptomų kontrolę, sumažinti paūmėjimų riziką, bronchų obstrukciją ir su vartojamais vaistais susijusius nepageidaujamas reakcijas. Ne mažiau svarbu gerinti su sveikata susijusią gyvenimo kokybę. Sergančiųjų sunkia eozinofiline astma gyvenimo kokybės gerinimas prilygsta iššūkiui, nes eozinofilinei astmai būdingi pasikartojantys paūmėjimai, bloga ligos kontrolė, sparčiai blogėjanti plaučių funkcija, blogėjanti su sveikata susijusi gyvenimo kokybė. Pastebėta, kad, gydant mepolizumabu – anti-IL-5 monokloniniu antikūnu, – gyvenimo kokybė reikšmingai pagerėja, o pats gydymas saugus. Todėl šie rezultatai rodo, kad mepolizumabo pridėjimas prie standartinio astmos gydymo gali turėti reikšmingą teigiamą poveikį.
Vegetal Scale in the Anthropocene: The Dark Green
Authors: Sullivan Heather Isabella
Published: October 2020

When exploring the problem of delineating possible “scales” useful to describe the Anthropocene’s ecological changes, I suggest plant-human relations as the basis of our models rather than solely Human impact with a capital “H” as if a stand-alone species. Instead, human beings are a species within the photosynthesis-shaped, oxygen-infused atmosphere, and countering the ongoing industrial ecocide means seeking multispecies justice. One may claim that the “vegetal” stands as the ontological antithesis of being “animal,” but that view expresses a one-dimensional disregard for the essential work and bodies of plants and their fellow photosynthesizers that produce oxygen, drive the carbon cycle, feed terrestrial life, and influence water cycles. Indeed, “animal” is an emergence from the vegetal context. But our plant stories are shifting with the anthropocenic inflection. This dark green project explores narratives, both scientific and creative, of plant-human interactions in time of planetary change; and these interactions are not always peaceful or on an easily comprehended scale. As an example, I consider the 2015 short science-fiction story from Alan Dean Foster, “That Creeping Sensation,” that portrays how plant-human relations take on frightening new forms in a climate-changed world altered by heat, carbon dioxide, and the not-always-supportive activities of plants. With all the heat and carbon dioxide, plant life explodes and produces a massive increase in oxygen. In response, insects grow enormous and specialized first-responders must battle the bugs. Foster’s texts portray scales of non-human agency larger than the human whose power encompasses, enables, and sometimes threatens human life. His “cli fi” tale of giant bugs presents human beings as inextricably enmeshed in a plant-dominated existence. To paraphrase Derrida, there is no outside the vegetal.