bluuebunny/crossref_metadata_2025 huggingface dataset:
Psychometrics and validation of the EQ-5D-5L instrument in individuals with ischemic stroke in Lithuania
Authors: Taroza Saulius , Burkauskas Julius , Mickuviene Narseta , Kazukauskiene Nijole , Podlipskyte Aurelija
Published: December 2023

Background

Experiencing stroke is associated with deterioration in health-related quality of life (HRQL). One of the generic tools used for HRQL assessment is the EuroQol instrument of five dimensions and five levels (EQ-5D-5L), which has not yet been validated in Lithuania. This study aimed to evaluate validity, reliability, and factor structure of the EQ-5D-5L instrument in a sample of Lithuanian individuals at the end of the first week after experiencing ischemic stroke (IS).

Methods

The study had a cross-sectional design, including 134 individuals [61.9% men and 38.1% women; median (IQR) age was 66 years (59–73) years, in the final analysis]. Alongside the EQ-5D-5L, psychological distress was evaluated using the Hospital Anxiety and Depression Scale (HADS), Patient Health Questionnaire-9 (PHQ-9), and Generalized Anxiety Disorder Assessment-7 (GAD-7); neurological impairment with the National Institutes of Health Stroke Scale (NIHSS); and functional independence with the Barthel index (BI). Confirmatory factor analysis (CFA) was performed for validation of the factor structure.

Results

The internal consistency of the EQ-5D-5L instrument was 0.81. A significant ceiling effect (17.2%) of the descriptive part of the EQ-5D-5L was detected. The convergent validity of the EQ-5D-5L descriptive system was confirmed, with significant correlations with the other scales used, except for the visual analog scale. The two-factor (“physical” and “emotional”) model was confirmed by CFA, with acceptable fit [root mean square error of approximation (RMSEA) = 0.045, RMSEA 90% CI = 0.000–0.145; comparative fit indices (CFI) = 0.996; non-normal fit index (NFI) = 0.983; Tucker–Lewis Index (TLI) = 0.936; χ2/df = 1.27)].

Conclusion

This study provides information on the psychometric properties of the EQ-5D-5L instrument in Lithuanian individuals, showing that the EQ-5D-5L descriptive system is a reliable and valid tool for HRQL assessment. The Lithuanian version of the descriptive part of the EQ-5D-5L instrument is best expressed as a two-factor model, estimating the physical and emotional dimensions of HRQL in individuals who have experienced IS.
Comparing the efficacy of electronic cognitive behavioral therapy to medication and combination therapy for generalized anxiety disorder: a quasi-experimental clinical trial
Authors: Stephenson Callum , Moghimi Elnaz , Shao Yijia , Kumar Anchan , Yee Caitlin S. , Miller Shadé , Stefatos Anthi , Gholamzadehmir Maedeh , Abbaspour Zara , Jagayat Jasleen , Shirazi Amirhossein , Gizzarelli Tessa , Gutierrez Gilmar , Khan Ferwa , Patel Charmy , Patel Archana , Yang Megan , Omrani Mohsen , Alavi Nazanin
Published: December 2023

Background

Generalized anxiety disorder (GAD) is a debilitating mental health disorder with first-line treatments include cognitive behavioral therapy (CBT) and pharmacotherapy. CBT is costly, time-consuming, and inaccessible. Electronic delivery (e-CBT) is a promising solution to address these barriers. However, due to the novelty of this intervention, more research testing the e-CBT efficacy independently and in conjunction with other treatments is needed.

Objective

This study investigated the efficacy of e-CBT compared to and in conjunction with pharmacotherapy for GAD.

Methods

This study employed a quasi-experimental design where patients selected their preferred treatment modality. Patients with GAD were enrolled in either e-CBT, medication, or combination arms. The 12-week e-CBT program was delivered through a digital platform. The medications followed clinical guidelines. The efficacy of each arm was evaluated using questionnaires measuring depression, anxiety, and stress severity, as well as quality of life.

Results

There were no significant differences between arms (N e-CBT = 41; N Medication = 41; N Combination = 33) in the number of weeks completed or baseline scores. All arms showed improvements in anxiety scores after treatment. The medication and combination arms improved depression scores. The e-CBT and Combination arms improved quality of life, and the combination arm improved stress scores. There were no differences between the groups in depression, anxiety, or stress scores post-treatment. However, the combination arm had a significantly larger improvement in quality of life. Gender and treatment arm were not predictors of dropout, whereas younger age was.

Conclusion

Incorporating e-CBT on its own or in combination with pharmaceutical interventions is a viable option for treating GAD. Treating GAD with e-CBT or medication appears to offer significant improvements in symptoms, with no meaningful difference between the two. Combining the treatments also offer significant improvements, while not necessarily superior to either independently. The findings suggest that all options are viable. Taking the patient’s preferred treatment route based on their lifestyle, personality, and beliefs into account when deciding on treatment should be a priority for care providers.
User needs and design features of sanitation digital solutions in Kawempe division, Kampala Uganda: a user centered design approach
Authors: Mukasa Comfort Hajra , Nankanja Maureen , Walude Mtwalib , Muzini Maurice , Kagurusi Patrick
Published: December 2023

Despite improvements in access to water and sanitation services globally, a significant population in Sub Saharan Africa has limited access to improved sanitation facilities. Furthermore, there is lack of a centralized digital platform for data exchange among stakeholders for sanitation services planning and provision in Uganda. A user centered design (UCD) approach was used to develop and pilot a one stop sanitation digital solutions (SaniDigS) center in Kawempe division, Kampala, Uganda. This involved three phases (1) understanding the sanitation status of the community which involved interviewing 1,844 household heads, (2) specifying the user needs of the proposed digital solution through stakeholder meetings and (3) Co designing of the innovations with potential users through stakeholder workshops. The quantitative data was visualized through the SaniDigS platform dashboard. The stakeholder meeting transcripts and notes were thematically analyzed to identify the user needs. The community user needs included an innovation that ensures confidentiality, is low cost and user friendly without internet connection. The service provider needed a sanitation digital solution that can market their sanitation products while, policy makers and planners needed comprehensive, real time data collection and sharing for trend analysis and informed decision making. The codesigned features of the SaniDigS informed by the user needs included: The SaniDigS Champion Application, SaniDigS platform dashboard, SaniDigS mobile application and the call center. The community in Kawempe showed need for subsidized sanitation products and we recommend further research to evaluate the effects of SaniDigS on planning, coordination, and access to sanitation services.
Use of #NutritionFacts to promote evidence-based nutrition information: X (formerly Twitter) hashtag analysis study
Authors: Matin Maima , Joshi Tanuj , Greger Michael , Bin Matin Farhan , Jóźwik Artur , Wierzbicka Agnieszka , Horbańczuk Jarosław Olav , Willschke Harald , Atanasov Atanas G.
Published: December 2023

Nutrition is a key determinant of health, and the dissemination of reliable nutrition information to consumers is of great importance for public health. Especially with the rise of digital communication technologies and the wide-spread online misinformation, the provision of qualitative science-based information related to diet is of great importance. The NutritionFacts.org has been established as a prominent online source of evidence-based nutrition information. In this work we aimed to investigate the use of the associated hashtag #NutritionFacts on X (formerly Twitter) over a 5 years period, from 10th of April 2018 to 10th of April 2023. The conducted analysis with the use of Symplur Signals revealed that 18,998 tweets mentioning #NutritionFacts were posted by 6,136 X users, generating a total of 50,348,223 impressions (views). Both institutional and individual accounts were broadly participating in the dissemination of #NutritionFacts tweets, and the user location profiling indicated wide international engagement with the hashtag. This work indicates that #NutritionFacts has been established as an important hashtag utilized on X for the dissemination of evidence-based information related to nutrition.
Ergonomic dual four-bar linkage knee exoskeleton for stair ascent assistance
Authors: Kittisares Sarin , Ide Tohru , Nabae Hiroyuki , Suzumori Koichi
Published: December 2023

Introduction: Robotic exoskeletons are emerging technologies that have demonstrated their effectiveness in assisting with Activities of Daily Living. However, kinematic disparities between human and robotic joints can result in misalignment between humans and exoskeletons, leading to discomfort and potential user injuries.

Methods: In this paper, we present an ergonomic knee exoskeleton based on a dual four-bar linkage mechanism powered by hydraulic artificial muscles for stair ascent assistance. The device comprises two asymmetric four-bar linkage mechanisms on the medial and lateral sides to accommodate the internal rotation of the knee and address the kinematic discrepancies between these sides. A genetic algorithm was employed to optimize the parameters of the four-bar linkage mechanism to minimize misalignment between human and exoskeleton knee joints. The proposed device was evaluated through two experiments. The first experiment measured the reduction in undesired load due to misalignment, while the second experiment evaluated the device’s effectiveness in assisting stair ascent in a healthy subject.

Results: The experimental results indicate that the proposed device has a significantly reduced undesired load compared to the traditional revolute joint, decreasing from 14.15 N and 18.32 N to 1.88 N and 1.07 N on the medial and lateral sides, respectively. Moreover, a substantial reduction in muscle activities during stair ascent was observed, with a 55.94% reduction in surface electromyography signal.

Discussion: The reduced undesired load of the proposed dual four-bar linkage mechanism highlights the importance of the adopted asymmetrical design for reduced misalignment and increased comfort. Moreover, the proposed device was effective at reducing the effort required during stair ascent.
Examining differences in menstrual and intimate care product use by race/ethnicity and education among menstruating individuals
Authors: Zota Ami R. , Franklin Elissia T. , Weaver Emily B. , Shamasunder Bhavna , Williams Astrid , Siegel Eva L. , Dodson Robin E.
Published: December 2023

Introduction

United States consumers spend over two billion dollars a year on intimate care products. These products, along with scented menstrual products, are marketed for odor control, perceived “freshness,” and vaginal/vulvar cleanliness. However, these scent-altering products may increase exposure to carcinogenic and endocrine-disrupting chemicals. Prior research has not adequately characterized demographic differences in product use. The objective of our study is to examine racial/ethnic and educational differences in menstrual and intimate care product use among people who menstruate.

Methods

We pooled data from two US-based cross sectional studies to examine demographic characteristics and product use in 661 participants aged 18–54 years. Participants reported use of scented and unscented menstrual products (tampons, sanitary pads, and menstrual cups) and intimate care products (vaginal douches, sprays, wipes, and powders). We examined differences by race/ethnicity and education using log-binomial regression and latent class analysis (LCA), which can identify groups based on product use patterns.

Results

Our sample was 33.4% Black, 30.9% Latina, 18.2% White, and 16.2% another identity. Approximately half the population had a bachelor's degree or more; 1.4% identified as transgender and 1.8% as non-binary. In adjusted models, scent-altering products (i.e., scented menstrual and intimate care products) were more likely to be used by those with less formal education (p < 0.05). Unscented menstrual products were more likely to be used by those with more formal education. Compared to Black participants, White participants were more likely to use unscented tampons and menstrual cups and less likely to use douches and wipes (p < 0.05). Using LCA we identified two groups: one more likely to use scent-altering products, and a second more likely to use unscented menstrual products. Less education and older age, but not race/ethnicity, was significantly associated with membership in the group more likely to use scent-altering products. While sex/gender composition did not statistically vary across groups, all non-binary participants fell in the unscented menstrual product group.

Discussion

Lower educational attainment was consistently associated with greater use of scent-altering menstrual and intimate care products. Future research should examine associations between body odor stigma, product use, and health risks at intersections of race, class, and gender.
Sediment-Nitrogen (N) connectivity: suspended sediments in streams as N exporters and reactors for denitrification and assimilatory N uptake during storms
Authors: Joshi Bisesh , Bacmeister Eva , Peck Erin , Peipoch Marc , Kan Jinjun , Inamdar Shreeram
Published: December 2023

Nitrogen (N) pollution in riverine ecosystems has substantial environmental, economic, and policy consequences. Various riverine N removal processes include permanent dissimilatory sinks such as denitrification (Uden) and temporary assimilatory sink such as microbial N uptake (Uassim). Both processes have been extensively evaluated in benthic sediments but only sparsely in the water column, particularly for storm flows producing high suspended sediment (SS) concentrations. Stormflows also increase the sediment bound N (Sed-N) export, and in turn, the overall N exports from watersheds. The balance between N removal by Uden and Uassim vs. Sed-N export has not been studied and is a key knowledge gap. We assessed the magnitude of Uden and Uassim against stormflow Sed-N exports for multiple storm events of varying magnitude and across two drainage areas (750 ha and 15,330 ha) in a mixed landuse mid-Atlantic US watershed. We asked: How do the Uden and Uassim sinks compare with Sed-N exports and how do these N fluxes vary across the drainage areas for sampled storms on the rising and falling limbs of the discharge hydrograph? Mean Uden and Uassim as % of the Sed-N exports ranged between 0.1–40% and 0.6–22%, respectively. Storm event Uassim fluxes were generally slightly lower than the corresponding Uden fluxes. Similarly, comparable but slightly higher Uden fluxes were observed for the second order vs. the fourth order stream, while Uassim fluxes were slightly higher in the fourth-order stream. Both of these N sinks were higher on the falling vs. rising limbs of the hydrograph. This suggests that while the N sinks are not trivial, sediment bound N exports during large stormflows will likely overshadow any gains in N removal by SS associated denitrification. Understanding these N source-sink dynamics for storm events is critical for accurate watershed nutrient modeling and for better pollution mitigation strategies for downstream aquatic ecosystems. These results are especially important within the context of climate change as extreme hydrological events including storms are becoming more and more frequent.
A questionnaire-based survey in Spain provides relevant information to improve the control of ovine coccidiosis
Authors: Sánchez-Sánchez Roberto , Gutiérrez Jorge , Blasco-Castello José Luis , Marcos-Santamaría María , Cano-Alsua Santiago , Elvira Laura , Ferre Ignacio , Ortega-Mora Luis Miguel
Published: December 2023

Ovine coccidiosis is a widespread intestinal parasitic disease caused by Eimeria spp. Lambs are infected by the ingestion of sporulated oocysts, experiencing diarrhea and low growth rates. Control should be based on measures to reduce infection pressure and stress on the animals as well as on appropriate diagnosis and strategic treatment. To obtain information on how control measures are implemented in the ovine sector in Spain, a questionnaire-based survey was completed in 2022 by 154 veterinarians and 173 farmers working in this sector. Coccidiosis was highlighted as a relevant disease by 34% of the respondents. The period of greatest risk seemed to differ between production systems, being mainly early after weaning (7–15 days after weaning) in meat flocks and feedlots and later (1–2 months after weaning) in dairy flocks. The absence of cleaning and disinfection measures was identified as a risk factor by 51% of the veterinarians, with 22% mentioning overcrowding of animals and 22% indicating that coccidiosis has more incidence in flocks with large number of animals. The use of laboratory diagnosis methods (fecal oocyst count) was unusual in 70 and 84% of the veterinarians and farmers, respectively. Regarding control, dairy flocks usually housed a larger number of animals under intensive conditions, and they implemented more frequently control measures for coccidiosis than meat flocks. Anticoccidial drugs were used in 79% of the flocks, and in 74–82% of them, they were applied based on clinical criteria. Comparing protocols for anticoccidial treatment among different production systems, in meat flocks, anticoccidial drugs were applied more frequently when clinical signs were observed, and coccidiostats were used for less than 28 days compared to dairy flocks. These results highlight the need for improvement in the use of anticoccidial treatments adjusted to the new regulatory framework in the EU, which in turn will rationalize the use of antimicrobial compounds and may help to mitigate the impact of coccidiosis in flocks.
On the Blueprint of the Long Primary Afferent Axons and the Dichotomous Axon Trajectory of Clarke’s Nucleus. A Morphological Tracing Study on the Effect of Hypoxia during Development
Authors: de Beer Frits C. , Steinbusch Harry W.
Published: December 2023

The primary afferent system in the rat’s spinal cord starts to develop in the third last week of gestation. First, the pseudounipolar DRG neurons extend their centripetal long primary axons, targeting rostral supra-segmental nuclei in the spinal cord. Meanwhile, the subsequent innervation of the juxta- and intra-segmental spinal levels enables the three subdivisions to commence integrating a complex network with the body periphery. This process may continue to refine and adapt the system life-long. The experimental data elucidated the steps involved in developing the cytoarchitecture by separating the axons of the long and intermediate subdivisions from the short subdivision. Here, we present a blueprint of the features of the long primary afferent axons developing in sequential waves. The pioneering long afferent axons targeted the dorsal gracile nuclei at spring tide and Clarke’s nuclei at neap tide in ventrally bent trajectories. The paradigm’s myelotomy blocked these pioneering fibers from stepping down the developmental cascade, rendering an unknown phenotype. This reflected a hypothetical transition hub stationed on the assembly line, delineating a critical period. The paradigm also affected the neuropil’s ripening independently from the long primary afferent system. The data disclosed that fetal hyposaturation yielded an in vivo genomic engineering capability. Fetal tissue was susceptible to hyposaturation, showing remarkable versatility early in fetal life. The translational impact may favor research into the elusive etiology of clinical syndromes concerning the afferent system relating to fetal hyposaturation.
Effect of Tryptophan Dietary Content on Meagre, Argyrosomus regius, Juveniles Stress and Behavioral Response
Authors: Vasconcelos Ana , Soares Marta C. , Barata Marisa , Couto Ana , Teixeira Bárbara , Ribeiro Laura , Pousão-Ferreira Pedro , Mendes Rogério , Saavedra Margarida
Published: December 2023

There are a high number of stressors present in aquaculture that can affect fish welfare and quality. One way of mitigating stress response is by increasing dietary tryptophan. In this study, three diets containing 0.5% (Tript1), 0.6% (Tript2), and 0.8% (Tript3) of tryptophan were tested in 32 g juvenile meagre for 56 days. At the end of the trial, survival, growth, and proximate composition were similar between treatments. Significant differences were found in the plasma parameters before and after a stress test consisting of 30 s of air exposure. Blood glucose levels were higher in the post-stress for all treatments (e.g., 63.9 and 76.7 mg/dL for Tript1 before and after the stress test), and the hemoglobin values were lower in the post-stress of Tript1 (1.9 g/dL compared to 3.0 and 2.4 g/dL for Tript2 and Tript3, respectively). In terms of behavior, three tests were carried out (novel tank diving and shoaling assays, and lateralization test), but no significant differences were found, except for the number of freezing episodes during the anxiety test (1.4 for Tript3 compared to 3.5 and 4.2 for the other treatments). This study suggests that supplementation with dietary tryptophan, particularly in higher dosage (0.8%), can reduce anxiety-like behavior in meagre exposure to acute stress (novel tank). Although the remaining results showed mild effects, they provide some clues as to the potential of this amino acid as a stress mitigator in aquaculture.
The Impact of Antioxidants on Vitiligo and Melasma: A Scoping Review and Meta-Analysis
Authors: Speeckaert Reinhart , Bulat Vedrana , Speeckaert Marijn M. , van Geel Nanja
Published: December 2023

Reactive oxygen species (ROS) generated during melanogenesis make melanocytes particularly vulnerable to oxidative stress, influencing their survival and melanin synthesis. Oxidative stress, significantly present in vitiligo and recently also detected in melasma, triggers inflammatory cascades and melanogenesis, making antioxidants a promising therapeutic avenue. A systematic search was conducted on Embase and Pubmed to study the efficacy of antioxidants for treating vitiligo and/or melasma. Meta-analysis was performed to assess the difference in Melasma Severity Index (MASI) scores between baseline and follow-up. Various antioxidants like polypodium leucotomos, ginkgo biloba, catalase/superoxide dismutase, and vitamin E have potential in vitiligo. For melasma, vitamin C, silymarin, and niacinamide were among those showing promise in reducing pigmentation, with vitamin C displaying significant effects in meta-analysis. Different antioxidants improve both vitiligo and melasma, with an increased minimal erythema dose (MED) following UV exposure being significant for vitiligo and tyrosinase inhibition being crucial for melasma. However, the efficacy of individual antioxidants varies, and their exact mechanisms, especially in stimulating melanocyte proliferation and anti-inflammatory pathways, require further investigation to understand better and optimize their use.
Experimental Study of the Multiple Fractalisation of Coal and Rock Failure Subjected to the Coupled Effects of Water, Temperature and Dynamic Loads
Authors: Jin Tingxu , Sun Xiaoyuan , Liu Kai , Lin Shurong , Yang Shaoqiang , Xie Jianlin
Published: December 2023

The mechanical properties of water-rich coal and rock in a subzero environment are very different from those at room temperature, which causes many unexpected hazards for projects. In this study, coal and rock samples subjected to the coupled effects of water, temperature, and dynamic loads were taken as the research object, and the discussion was shaped around their mechanical properties. The crack evolution trend and different gradient impact velocities were determined using a split-Hopkinson pressure bar (SHPB). Multiple fractals were based on high-speed digital image correlation (HS-DIC) technology and the quality-screening method; the evolution trend of the surface cracks in the crushing process and the distribution characteristics of the specimen fragments after crushing were examined from the perspective of fractals. This provided a powerful supplement to the existing research system on the problem of mining via the freezing method, and it accounted for the shortcomings of the existing research to a certain extent. In this research, the results mainly showed four points: (1) The coal samples were determined to have a wave velocity between 1.68 and 2.01 km/s, while the rock samples were between 2.24 and 2.61 km/s. Under the same conditions, the rock’s resistance to deformation and damage was greater than that of coal. (2) In the saturated state, the plastic strength of the coal and rock samples was greater than that in the dry state, due to the strengthening of their internal stresses caused by the presence of fissure water. (3) With decreasing temperature, the degree of the dynamic compression factor of coal and rock showed a trend of initially increasing, then decreasing, and then increasing. With the increase in the loading rate, the destruction of the coal and rock was more intense, and the destruction process was accelerated. (4) After the saturated coal and rock samples were frozen, their interiors were affected by the dual factors of contraction under the influence of temperature and expansion under the influence of the freezing expansion force. The internal fissures closed or shrank, and the water in the pores turned into ice, leading to an increase in pore volume.
Bisection Constraint Method for Multiple-Loading Conditions in Structural Topology Optimization
Authors: Pham-Truong Thi , Kawamura Yasumi , Okada Tetsuo
Published: December 2023

Topology optimization (TO) is currently a focal point for researchers in the field of structural optimization, with most studies concentrating on single-loading conditions. However, real engineering structures often have to work under various loading conditions. Approaches addressing multiple-loading conditions often necessitate subjective input in order to determine the importance of each loading condition, aiming for a compromise between them. This paper proposes a so-called bisection constraint method (BCM), offering a unique, user-preference-independent solution for TO problems amidst multiple-loading conditions. It is well-known that minimizing the system’s compliance is commonly used in TO as the objective. Generally, compliance is not as sufficient as stress to be used as a response to evaluate the performance of structures. However, formulations focusing on minimizing stress levels usually pose significant difficulties and instabilities. On the other hand, the compliance approach is generally simpler and more capable of providing relatively sturdy designs. Hence, the formulation of min–max compliance is used as the target problem formulation of the proposed method. This method attempts to minimize compliance under only one loading condition while compliances under the remaining loading conditions are constrained. During the optimization process, the optimization problem is automatically reformulated with a new objective function and a new set of constraint functions. The role of compliance under different loading conditions, i.e., whether it is to be treated as an objective or constraint function, might be changed throughout the optimization process until convergence. Several examples based on the solid isotropic material with penalization (SIMP) approach were conducted to illustrate the validity of the proposed method. Furthermore, the general effectiveness of the compliance approach in terms of stress levels is also discussed. The calculation results demonstrated that while the compliance approach is effective in several cases, it proves ineffective in certain scenarios.
Numerical Analysis of Low-Cost Recognition of Tunnel Cracks with Compressive Sensing along the Railway
Authors: Chen Jinfeng , Mei Meng
Published: December 2023

Currently, the use of microseismic detection technology for crack detection and localization in rock masses has great potential in detecting structural damage. As engineering safety has always been a very important issue, this study investigated the problem of multi-crack identification in rock masses within the environment of track tunnels using transient waves. A tunnel rock was modeled using MIDAS GTS NX software (2019.v1.2) and a crack transient wave model in the frequency domain was obtained through data analysis and simulation. Then, this was combined with compressive sensing techniques to locate and detect multiple cracks in tunnel rock. The performance of the proposed approach was validated through experimental simulations, which included experiments on differences in the number of cracks, as well as spatial samples. The experimental results indicate that the technique performs well for single-crack localization in tunnel rock mass, where the average localization error is 4 m. Meanwhile, the localization error is larger in multi-crack localization, and the number of spatial sample points set using compressive sensing also has a large impact on the experimental results.
The Relationship between Urban Expansion and Air Pollution Depends on Urban Spatial Morphology in the “2 + 26” Cities of Beijing-Tianjin-Hebei, China
Authors: Ye Shen , Wang Peng , Chen Qingyan , Huang Yi , She Yuanyang
Published: December 2023

Urban spatial morphology reflects the processes of external urban expansion and the internal spatial structure of the human economy, and exploring urban spatial morphology is important for regional management of PM2.5 pollutants in the air environment. Whether urban spatial morphology can influence air pollution is a question that has been explored and evaluated. Therefore, we constructed a spatial-temporal driving mechanism framework and explored the interactions among urban expansion and PM2.5 pollutants in the “2 + 26” cities of Beijing-Tianjin-Hebei (BTH). Based on 2010, 2015, and 2020 urban expansion factors and PM2.5 pollutants data from the “2 + 26” cities of BTH, the results of the Geo-Detector medal imply that: (1) The spatial distribution characteristics of areas with high PM2.5 pollutants in the “2 + 26” cities of BTH were affected by the PM2.5 concentration value, and the high-value phenomenon appeared to decrease with the improvement of PM2.5 pollutants. (2) The level of urbanization in the “2 + 26” cities of BTH had been increasing annually, with the most significant growth in construction land area located in the northeastern coastal cities. (3) The compactness index, was the most critical influencing urban expansion factor, explaining 0.63, 0.64, and 0.66 of PM2.5 pollutants in 2010, 2015, and 2020. (4) In factorial interactions, the compactness index and the centrality ratio explained spatial and temporal analysis characteristics of PM2.5 pollutants, and the interaction factor enhanced the explanation for the spatial-temporal characteristics. This study reveals the coupled spatial-temporal driving mechanism of air pollution in the “2 + 26” cities of BTH and also shows that reasonable urban planning has a positive impact on the regional ecological environment in the future.
Design and Experimental Verification of PUC Multilevel Inverter-Based PMSG Wind Energy Conversion System
Authors: Hasirci Habip Yusuf , Vural Ahmet Mete
Published: December 2023

In this study, a wind energy conversion system is designed using a three-phase permanent magnet synchronous generator, a six-diode bridge rectifier, a DC–DC boost converter, an inverter, and a load. The proposed inverter is a Packed U-Cell-based multilevel inverter having five or seven voltage levels at the output. It is also a topology that is not widely used in wind energy applications. Furthermore, a dual-mode PI-PI control technique is proposed to regulate the auxiliary capacitor voltage in the PUC MLI. The inverter is designed and simulated for a permanent magnet synchronous generator-based variable speed wind energy conversion system. Additionally, the design and experimental application of the proposed system is carried out in a laboratory environment. In the experimental application, the rated voltage of the Packed U-Cell multilevel inverter is chosen as 45 V. The switching frequency of the multilevel inverter is set to 4 kHz, and a generator with rated power of 700 W is selected. The output voltage of the generator is varied between 25 V and 35 V through an induction motor. This varying voltage is increased to 45 V using a DC–DC boost converter. Finally, it is observed that the power generated by the permanent magnet synchronous generator is successfully transferred to the load and the designed system operates with low harmonic content.
ResADM: A Transfer-Learning-Based Attack Detection Method for Cyber–Physical Systems
Authors: Wang Huan , Zhang Haifeng , Zhu Lei , Wang Yan , Deng Junyi
Published: December 2023

Deep learning has proven to be effective for enhancing the accuracy and efficiency of attack detection through training with large sample sizes. However, when applied to cyber–physical systems (CPSs), it still encounters challenges such as scarcity of attack samples, the difficulty of selecting features for high-dimensional data, and weak model-generalization ability. In response, this paper proposes ResADM, a transfer-learning-based attack detection method for CPSs. Firstly, an intentional sampling method was employed to construct different sets of samples for each class, effectively balancing the distribution of CPS-attack samples. Secondly, a feature-selection method based on importance was designed to extract the meaningful features from attack behaviors. Finally, a transfer-learning network structure based on ResNet was constructed, and the training parameters of the source model were optimized to form the network-attack detection method. The experimental results demonstrated that ResADM effectively balanced the data classes and extracted 32-dimensional attack-behavior features. After pre-training on the UNSW-NB15 dataset, ResADM achieved a detection accuracy of up to 99.95% for attack behavior on the CICIDS2017 dataset, showcasing its strong practicality and feasibility.
A Hybrid-Cryptography Engine for Securing Intra-Vehicle Communications
Authors: Tiberti Walter , Civino Roberto , Gavioli Norberto , Pugliese Marco , Santucci Fortunato
Published: December 2023

While technological advancements and their deep integration in connected and automated vehicles is a central aspect in the evolving trend of automotive industry, they also depict a growing size attack surface for malicious actors: the latter ones typically aim at exploiting known and unknown security vulnerabilities, with potentially disastrous consequences on the safety of vehicles, people, and infrastructures. In recent years, remarkable efforts have been spent to mitigate security vulnerabilities in intelligent and connected vehicles, in particular in the inside of vehicles, the so-called intra-vehicle networks. Despite those efforts, securing intra-vehicle networks remains a non-trivial task due to their heterogeneous and increasingly complex context. Starting from the above remarks and motivated by the industrial research and innovation project EMERGE, in this paper we report on a novel cryptographic hardware-software solution that we have designed and developed for securing the intra-vehicle network of intelligent connected vehicles: the Crypto-Engine. The Crypto-Engine relies on a lightweight hybrid-key cryptographic scheme to provide confidentiality and authentication without compromising the normal communication performance. We tested the Crypto-Engine and demonstrated that, once configured according to application-defined performance requirements, it can authenticate parties and secure the communications with a negligible overhead.
Intelligent Data-Enabled Task Offloading for Vehicular Fog Computing
Authors: Alfakeeh Ahmed S. , Javed Muhammad Awais
Published: December 2023

Fog computing is a key component of future intelligent transportation systems (ITSs) that can support the high computation and large storage requirements needed for autonomous driving applications. A major challenge in such fog-enabled ITS networks is the design of algorithms that can reduce the computation times of different tasks by efficiently utilizing available computational resources. In this paper, we propose a data-enabled cooperative technique that offloads some parts of a task to the nearest fog roadside unit (RSU), depending on the current channel quality indicator (CQI). The rest of the task is offloaded to a nearby cooperative computing vehicle with available computing resources. We developed a cooperative computing vehicle selection technique using an artificial neural network (ANN)-based prediction model that predicts both the computing availability once the task is offloaded to the potential computing vehicle and the link connectivity when the task result is to be transmitted back to the source vehicle. Using detailed simulation results in MATLAB 2020a software, we show the accuracy of our proposed prediction model. Furthermore, we also show that the proposed technique reduces total task delay by 37% compared to other techniques reported in the literature.
Image-Guided Surgical and Pharmacotherapeutic Routines as Part of Diligent Medical Treatment
Authors: Razek Adel
Published: December 2023

This contribution is part of the objective of diligent universal care that ensures the well-being of a patient. It aims to analyze and propose enriched image-guided procedures for surgical interventions and restricted delivery of implanted drugs in minimally invasive and non-ionizing circumstances. This analysis is supported by a literature review conducted in two ways. The first aims to illustrate the importance of recent research and applications involved in different topics of the subject; this is mainly the case for the introduction’s literature. The second concerns the literature dedicated to having more detailed information in context; this mainly concerns the citations in the different sections of the article. The universal goals of medical treatments are intended to involve the well-being of the patient and allow medical personnel to test new therapies and carry out therapeutic training without risk to the patient. First, the various functionalities involved in these procedures and the concerns of the magnetic resonance imaging technique (MRI) and ultrasound imaging technique (USI), recent contributions to the subject are reviewed. Second, the intervention procedures guided by the image and the implemented actions are analyzed. Third, the components of the fields involved in MRI are examined. Fourth, the MRI control of the treatments, its performance and its compliance are analyzed. Compatibility with MRI via electromagnetic compatibility (EMC) is conferred and demonstrated for an actuation example. Fifth, the extension of the concepts mentioned in the article, in the context of patient comfort and the training of medical staff is proposed. The main contribution of this article is the identification of the different strategic aids needed in healthcare related to image-assisted robotics, non-ionized, minimally invasive and locally restrictive means. Furthermore, it highlights the benefits of using phantoms based on real biological properties of the body, digital twins under human control, artificial intelligence tools and augmented reality-assisted robotics.
Photoionization Study of Neutral Chlorine Atom
Authors: Gning Momar Talla , Sakho Ibrahima
Published: December 2023

Photoionization of neutral chlorine atom is investigated in this paper in the framework of the screening constant per unit nuclear charge (SCUNC) method. Resonance energies, quantum defects and effective charges of the 3s23p4 (3P2,1,0)ns and 3s23p4 (3P1,0)nd Rydberg series originating from both the 2P03/2 ground state and the 2P01/2 excited state of chlorine atom are reported. The present study believed to be the first theoretical investigation is compared with the recent experimental measurements (Yang et al., Astrophys. J. 810:132, 2015). Good agreements are obtained between theory and experiments. New SCUNC data are tabulated as useful references for interpreting astrophysical spectra from neutral atomic chlorine.
Evaluation of Cochlear Symptoms in Migraine Patients without Vestibular Migraine and/or Ménière’s Disease
Authors: Gambacorta Valeria , Ricci Giampietro , D’Orazio Alessandra , Stivalini Davide , Baietta Irene , Pettorossi Vito Enrico , Faralli Mario
Published: December 2023

Migraine pathogenic pathways may selectively target the cochlea. A qualitative and quantitative analysis of cochlear symptoms in migraine patients without vestibular migraine and/or Méniere’s disease was conducted. We examined 60 consecutive patients with history of cochlear symptoms, including fullness, tinnitus, and hearing loss. Patients were divided into two groups based on migraine history: M (migraine) and nM (no migraine). The incidence of migraine was compared to a homogeneous control group with dysfunctional and inflammatory dysphonia without cochlear symptoms. The type, time of onset, recurrence, bilaterality of symptoms, and hearing threshold were analyzed. The incidence of migraine was significantly higher (p = 0.04) in patients with cochlear symptoms than in the control group. The onset of symptoms is significantly earlier (p < 0.05) in the presence of migraine. The fullness, recurrence, and bilaterality of symptoms are associated with migraine in a statistically significant way (p < 0.05). Pure tone audiometry shows a statistically significant increase in the hearing threshold (500–1000 Hz) in group M. Based on developing findings, cochlear migraine may be considered as a novel clinical entity, like vestibular migraine. It would be the expression, in the absence of vertiginous symptoms, of a selective suffering of the anterior labyrinth by known operating mechanisms of migraine.
Aging and Homogenized Mechanical Character of Quasi-Statically Charged Gr-Si and NMC Based Electrodes Using Damage Material Modeling
Authors: Ahmed Shahbaz , Zausch Jochen , Grimm-Strele Hannes , Kabel Matthias
Published: December 2023

Silicon-based, high-energy-density electrodes show severe microstructural degradation due to continuous expansion and contraction upon charging and discharging. This mechanical degradation behaviour affects the cell’s lifetime by changing the microstructure morphology, altering transport parameters, and active volume losses. Since direct experimental observations of mechanical degradation are challenging, we develop a computer simulation approach that is based on real three-dimensional electrode microstructures. By assuming quasi-static cycling and taking into account the mechanical properties of the electrode’s constituents we calculate the heterogeneous deformation and resulting morphological changes. Additionally, we implement an ageing model that allows us to compute a heterogeneously evolving damage field over multiple cycles. From the damage field, we infer the remaining electrode capacity. Using this technique, an anode blend of graphite particles and silicon carbon composite particles (SiC-C) as well as a cathode consisting of Lithium-Nickel-Manganese-Cobalt Oxide with molar ratio of 8:1:1 (NMC811) are studied. In a two-level homogenization approach, we compute, firstly, the effective mechanical properties of silicon composite particles and, secondly, the whole electrode microstructure. By introducing the damage strain ratio, the degradation evolution of the graphite SiC-C anode blend is studied for up to 95 charge-discharge cycles. With this work, we demonstrate an approach to how mechanical damage of battery electrodes can be treated efficiently. This is the basis for a full coupling to electrochemical simulations.
The Effect of Cerclage Banding Distally to a Clamshell Fracture Pattern in Total Hip Arthroplasty—A Biomechanical Study
Authors: Kastner Philipp , Zderic Ivan , Gueorguiev Boyko , Pastor Torsten , Luger Matthias , Gotterbarm Tobias , Schopper Clemens
Published: December 2023

Objectives: As currently there is no existing biomechanical work on the topic of interest, the aim of the current study was to investigate the effect of cerclage banding distally to an intraoperatively occurring proximal periprosthetic femoral clamshell fracture versus a non-fractured femur after total hip arthroplasty. Methods: A diaphyseal anchoring stem was implanted in twenty paired human cadaveric femora, assigned to a treatment and a control group. In the treatment group, each specimen was fitted with a cerclage band placed 3 mm distally to a clamshell fracture, created with an extent of 40% of the anchoring length of the stem. The resulting fragment was not treated further. The contralateral specimens were left with the stems without further fracture creation or treatment. All constructs were tested under progressively increasing cyclic axial loading until failure. Relative bone-implant movements were monitored by motion tracking. Results: Number of cycles and the corresponding load at stem loosening, defined as 1 mm displacement of the stem along the shaft axis, were 31,417 ± 8870 and 3641.7 ± 887 N in the control group, and 26,944 ± 11,706 and 3194.4 ± 1170.6 N in the treatment group, respectively, with no significant differences between them, p = 0.106. Conclusion: From a biomechanical perspective, cerclage banding distally to an intraoperative clamshell fracture with an extent of 40% of the anchoring length of the stem demonstrated comparable resistance against hip stem loosening versus a non-fractured femur. It may therefore represent a valid treatment option to restore the full axial stability of a diaphyseal anchoring stem. In addition, it may be considered to keep the medial wall fragment unfixed, thus saving operative time and minimizing associated risks.
When Dad’s Stress Gets under Kid’s Skin—Impacts of Stress on Germline Cargo and Embryonic Development
Authors: Kretschmer Miriam , Fischer Vincent , Gapp Katharina
Published: December 2023

Multiple lines of evidence suggest that paternal psychological stress contributes to an increased prevalence of neuropsychiatric and metabolic diseases in the progeny. While altered paternal care certainly plays a role in such transmitted disease risk, molecular factors in the germline might additionally be at play in humans. This is supported by findings on changes to the molecular make up of germ cells and suggests an epigenetic component in transmission. Several rodent studies demonstrate the correlation between paternal stress induced changes in epigenetic modifications and offspring phenotypic alterations, yet some intriguing cases also start to show mechanistic links in between sperm and the early embryo. In this review, we summarise efforts to understand the mechanism of intergenerational transmission from sperm to the early embryo. In particular, we highlight how stress alters epigenetic modifications in sperm and discuss the potential for these modifications to propagate modified molecular trajectories in the early embryo to give rise to aberrant phenotypes in adult offspring.