bluuebunny/crossref_metadata_2025 huggingface dataset:
Data from PI3K Inhibition Restores and Amplifies Response to Ruxolitinib in patients with Myelofibrosis
Authors: Moyo Tamara K. , Kishtagari Ashwin , Villaume Matthew , McMahon Brandon , Mohan Sanjay R. , Stopczynski Tess , Chen Sheau-Chiann , Fan Run , Huo Yuankai , Moon Hyeonsoo , Tang Yucheng , Bejan Cosmin A. , Childress Merrida , Anderson Ingrid , Rawling Kyle , Simons Rhea M. , Moncrief Ashley , Caza Rebekah , Dugger Laura , Collins Aunshka , Dudley Channing V. , Ferrell P. Brent , Byrne Michael , Strickland Stephen A. , Ayers Gregory D. , Landman Bennett A. , Mason Emily F. , Mesa Ruben A. , Palmer Jeanne M. , Michaelis Laura C. , Savona Michael R.
Published: May 2023

Abstract
Purpose: Treatment options are limited beyond JAK inhibitors for patients with primary myelofibrosis (PMF), or secondary MF. Preclinical studies have revealed that PI3Kδ inhibition cooperates with ruxolitinib, a JAK1/2 inhibitor, to reduce proliferation and induce apoptosis of JAK2V617F mutant cell lines. Patients and Methods: In a phase I dose-escalation and expansion study, we evaluated the safety and efficacy of a selective PI3Kδ inhibitor umbralisib in combination with ruxolitinib in MF patients who had a suboptimal response or lost response to ruxolitinib. Enrolled subjects were required to be on a stable dose of ruxolitinib for ≥8 weeks and continue that maximally tolerated dose at study enrollment. The recommended dose of umbralisib in combination with ruxolitinib was determined using a modified 3+3 dose escalation design. Safety, pharmacokinetics, and efficacy outcomes were evaluated, and spleen size was measured with a novel automated digital atlas. Results: Thirty-seven MF patients with prior exposure to ruxolitinib were enrolled. 2 patients treated with 800mg umbralisib experienced reversible Grade 3 asymptomatic pancreatic enzyme elevation, but no dose-limiting toxicities were seen at lower umbralisib doses. Two patients (5%) achieved complete response (CR), and 12 patients (32%) met the IWG-MRT response criteria of clinical improvement (CI). With a median follow-up of 50.3 months for censored patients, overall survival was greater than 70% after 3 years of follow-up. Conclusions: Adding umbralisib to ruxolitinib in patients was well-tolerated and may re-sensitize MF patients to ruxolitinib without unacceptable rates of adverse events seen with earlier generation PI3Kδ inhibitors.
Data from Dynamic Intestinal Stem Cell Plasticity and Lineage Remodeling by a Nutritional Environment Relevant to Human Risk for Tumorigenesis
Authors: Choi Jiahn , Zhang Xusheng , Li Wenge , Houston Michele , Peregrina Karina , Dubin Robert , Ye Kenny , Augenlicht Leonard
Published: May 2023

Abstract
New Western-style diet 1 (NWD1), a purified diet establishing mouse exposure to key nutrients recapitulating levels that increase human risk for intestinal cancer, reproducibly causes mouse sporadic intestinal and colonic tumors reflecting human etiology, incidence, frequency, and lag with developmental age. Complex NWD1 stem cell and lineage reprogramming was deconvolved by bulk and single-cell RNA sequencing, single-cell Assay for Transposase-Accessible Chromatin using sequencing, functional genomics, and imaging. NWD1 extensively, rapidly, and reversibly, reprogrammed Lgr5hi stem cells, epigenetically downregulating Ppargc1a expression, altering mitochondrial structure and function. This suppressed Lgr5hi stem cell functions and developmental maturation of Lgr5hi cell progeny as cells progressed through progenitor cell compartments, recapitulated by Ppargc1a genetic inactivation in Lgr5hi cells in vivo. Mobilized Bmi1+, Ascl2hi cells adapted lineages to the nutritional environment and elevated antigen processing and presentation pathways, especially in mature enterocytes, causing chronic, protumorigenic low-level inflammation. There were multiple parallels between NWD1 remodeling of stem cells and lineages with pathogenic mechanisms in human inflammatory bowel disease, also protumorigenic. Moreover, the shift to alternate stem cells reflects that the balance between Lgr5-positive and -negative stem cells in supporting human colon tumors is determined by environmental influences. Stem cell and lineage plasticity in response to nutrients supports historic concepts of homeostasis as a continual adaptation to environment, with the human mucosa likely in constant flux in response to changing nutrient exposures.
Implications:
Although oncogenic mutations provide a competitive advantage to intestinal epithelial cells in clonal expansion, the competition is on a playing field dynamically sculpted by the nutritional environment, influencing which cells dominate in mucosal maintenance and tumorigenesis.
Dissecting Intra-tumor Heterogeneity in the Glioblastoma Microenvironment Using Fluorescence-Guided Multiple Sampling
Authors: García-Montaño Leopoldo A. , Licón-Muñoz Yamhilette , Martinez Frank J. , Keddari Yasine R. , Ziemke Michael K. , Chohan Muhammad O. , Piccirillo Sara G.M.
Published: May 2023

The treatment of the most aggressive primary brain tumor in adults, glioblastoma (GBM), is challenging due to its heterogeneous nature, invasive potential, and poor response to chemo- and radiotherapy. As a result, GBM inevitably recurs and only a few patients survive 5 years post-diagnosis. GBM is characterized by extensive phenotypic and genetic heterogeneity, creating a diversified genetic landscape and a network of biological interactions between subclones, ultimately promoting tumor growth and therapeutic resistance. This includes spatial and temporal changes in the tumor microenvironment, which influence cellular and molecular programs in GBM and therapeutic responses. However, dissecting phenotypic and genetic heterogeneity at spatial and temporal levels is extremely challenging, and the dynamics of the GBM microenvironment cannot be captured by analysis of a single tumor sample. In this review, we discuss the current research on GBM heterogeneity, in particular, the utility and potential applications of fluorescence-guided multiple sampling to dissect phenotypic and genetic intra-tumor heterogeneity in the GBM microenvironment, identify tumor and non-tumor cell interactions and novel therapeutic targets in areas that are key for tumor growth and recurrence, and improve the molecular classification of GBM.
Supplementary Figure 7 from Combinatorial BCL2 Family Expression in Acute Myeloid Leukemia Stem Cells Predicts Clinical Response to Azacitidine/Venetoclax
Authors: Waclawiczek Alexander , Leppä Aino-Maija , Renders Simon , Stumpf Karolin , Reyneri Cecilia , Betz Barbara , Janssen Maike , Shahswar Rabia , Donato Elisa , Karpova Darja , Thiel Vera , Unglaub Julia M. , Grabowski Susanna , Gryzik Stefanie , Vierbaum Lisa , Schlenk Richard F. , Röllig Christoph , Hundemer Michael , Pabst Caroline , Heuser Michael , Raffel Simon , Müller-Tidow Carsten , Sauer Tim , Trumpp Andreas
Published: May 2023

MAC-Score predict response within mutational subgroups
Supplementary Figure 5 from Combinatorial BCL2 Family Expression in Acute Myeloid Leukemia Stem Cells Predicts Clinical Response to Azacitidine/Venetoclax
Authors: Waclawiczek Alexander , Leppä Aino-Maija , Renders Simon , Stumpf Karolin , Reyneri Cecilia , Betz Barbara , Janssen Maike , Shahswar Rabia , Donato Elisa , Karpova Darja , Thiel Vera , Unglaub Julia M. , Grabowski Susanna , Gryzik Stefanie , Vierbaum Lisa , Schlenk Richard F. , Röllig Christoph , Hundemer Michael , Pabst Caroline , Heuser Michael , Raffel Simon , Müller-Tidow Carsten , Sauer Tim , Trumpp Andreas
Published: May 2023

Subpopulation specific Bcl-2 family levels and time on HMA/Venetoclax
Supplementary Figure 4 from Combinatorial BCL2 Family Expression in Acute Myeloid Leukemia Stem Cells Predicts Clinical Response to Azacitidine/Venetoclax
Authors: Waclawiczek Alexander , Leppä Aino-Maija , Renders Simon , Stumpf Karolin , Reyneri Cecilia , Betz Barbara , Janssen Maike , Shahswar Rabia , Donato Elisa , Karpova Darja , Thiel Vera , Unglaub Julia M. , Grabowski Susanna , Gryzik Stefanie , Vierbaum Lisa , Schlenk Richard F. , Röllig Christoph , Hundemer Michael , Pabst Caroline , Heuser Michael , Raffel Simon , Müller-Tidow Carsten , Sauer Tim , Trumpp Andreas
Published: May 2023

Subpopulation specific Bcl-2 family levels and response to HMA/Venetoclax
Supplementary Figure 1 from Combinatorial BCL2 Family Expression in Acute Myeloid Leukemia Stem Cells Predicts Clinical Response to Azacitidine/Venetoclax
Authors: Waclawiczek Alexander , Leppä Aino-Maija , Renders Simon , Stumpf Karolin , Reyneri Cecilia , Betz Barbara , Janssen Maike , Shahswar Rabia , Donato Elisa , Karpova Darja , Thiel Vera , Unglaub Julia M. , Grabowski Susanna , Gryzik Stefanie , Vierbaum Lisa , Schlenk Richard F. , Röllig Christoph , Hundemer Michael , Pabst Caroline , Heuser Michael , Raffel Simon , Müller-Tidow Carsten , Sauer Tim , Trumpp Andreas
Published: May 2023

Cell line sensitivity and additional patient data
HTLV-1 bZIP Factor-Induced Reprogramming of Lactate Metabolism and Epigenetic Status Promote Leukemic Cell Expansion
Authors: Toyoda Kosuke , Yasunaga Jun-ichirou , Shichijo Takafumi , Arima Yuichiro , Tsujita Kenichi , Tanaka Azusa , Salah Tarig , Zhang Wenyi , Hussein Osama , Sonoda Miyu , Watanabe Miho , Kurita Daisuke , Nakashima Kazutaka , Yamada Kyohei , Miyoshi Hiroaki , Ohshima Koichi , Matsuoka Masao
Published: May 2023

Acceleration of glycolysis is a common trait of cancer. A key metabolite, lactate, is typically secreted from cancer cells because its accumulation is toxic. Here, we report that a viral oncogene, HTLV-1 bZIP factor (HBZ), bimodally upregulates TAp73 to promote lactate excretion from adult T-cell leukemia-lymphoma (ATL) cells. HBZ protein binds to EZH2 and reduces its occupancy of the TAp73 promoter. Meanwhile, HBZ RNA activates TAp73 transcription via the BATF3-IRF4 machinery. TAp73 upregulates the lactate transporters MCT1 and MCT4. Inactivation of TAp73 leads to intracellular accumulation of lactate, inducing cell death in ATL cells. Furthermore, TAp73 knockout diminishes the development of inflammation in HBZ-transgenic mice. An MCT1/4 inhibitor, syrosingopine, decreases the growth of ATL cells in vitro and in vivo. MCT1/4 expression is positively correlated with TAp73 in many cancers, and MCT1/4 upregulation is associated with dismal prognosis. Activation of the TAp73–MCT1/4 pathway could be a common mechanism contributing to cancer metabolism.

Significance:

An antisense gene encoded in HTLV-1, HBZ, reprograms lactate metabolism and epigenetic modification by inducing TAp73 in virus-positive leukemic cells. A positive correlation between TAp73 and its target genes is also observed in many other cancer cells, suggesting that this is a common mechanism for cellular oncogenesis.

This article is featured in Selected Articles from This Issue, p. 337
TABLE 5 from Phase I Trial of Autologous RNA-electroporated cMET-directed CAR T Cells Administered Intravenously in Patients with Melanoma and Breast Carcinoma
Authors: Shah Payal D. , Huang Alexander C. , Xu Xiaowei , Orlowski Robert , Amaravadi Ravi K. , Schuchter Lynn M. , Zhang Paul , Tchou Julia , Matlawski Tina , Cervini Amanda , Shea Joanne , Gilmore Joan , Lledo Lester , Dengel Karen , Marshall Amy , Wherry E. John , Linette Gerald P. , Brennan Andrea , Gonzalez Vanessa , Kulikovskaya Irina , Lacey Simon F. , Plesa Gabriela , June Carl H. , Vonderheide Robert H. , Mitchell Tara C.
Published: May 2023

IHC analysis of paired tumor tissue
TABLE 4 from Phase I Trial of Autologous RNA-electroporated cMET-directed CAR T Cells Administered Intravenously in Patients with Melanoma and Breast Carcinoma
Authors: Shah Payal D. , Huang Alexander C. , Xu Xiaowei , Orlowski Robert , Amaravadi Ravi K. , Schuchter Lynn M. , Zhang Paul , Tchou Julia , Matlawski Tina , Cervini Amanda , Shea Joanne , Gilmore Joan , Lledo Lester , Dengel Karen , Marshall Amy , Wherry E. John , Linette Gerald P. , Brennan Andrea , Gonzalez Vanessa , Kulikovskaya Irina , Lacey Simon F. , Plesa Gabriela , June Carl H. , Vonderheide Robert H. , Mitchell Tara C.
Published: May 2023

mRNA signals corresponding to CAR T cells in peripheral blood
Supplementary Table 2 from Dissecting the Origin of Heterogeneity in Uterine and Ovarian Carcinosarcomas
Authors: Sertier Anne-Sophie , Ferrari Anthony , Pommier Roxane M. , Treilleux Isabelle , Boyault Sandrine , Devouassoux-Shisheboran Mojgan , Kielbassa Janice , Thomas Emilie , Tonon Laurie , Le Texier Vincent , Charreton Amandine , Morel Anne-Pierre , Floquet Anne , Joly Florence , Berton-Rigaud Dominique , Ferron Gwenaël , Arnould Laurent , Croce Sabrina , Bataillon Guillaume , Saintigny Pierre , Mery-Lamarche Eliane , Sagan Christine , Senaratne Aruni P. , Gut Ivo G. , Calvo Fabien , Viari Alain , Ouzounova Maria , Ray-Coquard Isabelle , Puisieux Alain
Published: May 2023

List of differentially expressed genes (paired analysis of 5 selected tumors).
Supplementary Table 1 from Dissecting the Origin of Heterogeneity in Uterine and Ovarian Carcinosarcomas
Authors: Sertier Anne-Sophie , Ferrari Anthony , Pommier Roxane M. , Treilleux Isabelle , Boyault Sandrine , Devouassoux-Shisheboran Mojgan , Kielbassa Janice , Thomas Emilie , Tonon Laurie , Le Texier Vincent , Charreton Amandine , Morel Anne-Pierre , Floquet Anne , Joly Florence , Berton-Rigaud Dominique , Ferron Gwenaël , Arnould Laurent , Croce Sabrina , Bataillon Guillaume , Saintigny Pierre , Mery-Lamarche Eliane , Sagan Christine , Senaratne Aruni P. , Gut Ivo G. , Calvo Fabien , Viari Alain , Ouzounova Maria , Ray-Coquard Isabelle , Puisieux Alain
Published: May 2023

Curated list of chromatin remodeling genes.
Figure S8 from Dissecting the Origin of Heterogeneity in Uterine and Ovarian Carcinosarcomas
Authors: Sertier Anne-Sophie , Ferrari Anthony , Pommier Roxane M. , Treilleux Isabelle , Boyault Sandrine , Devouassoux-Shisheboran Mojgan , Kielbassa Janice , Thomas Emilie , Tonon Laurie , Le Texier Vincent , Charreton Amandine , Morel Anne-Pierre , Floquet Anne , Joly Florence , Berton-Rigaud Dominique , Ferron Gwenaël , Arnould Laurent , Croce Sabrina , Bataillon Guillaume , Saintigny Pierre , Mery-Lamarche Eliane , Sagan Christine , Senaratne Aruni P. , Gut Ivo G. , Calvo Fabien , Viari Alain , Ouzounova Maria , Ray-Coquard Isabelle , Puisieux Alain
Published: May 2023

Alteration of genes of RAS pathway in uterine and ovarian CS.
Figure S6 from Dissecting the Origin of Heterogeneity in Uterine and Ovarian Carcinosarcomas
Authors: Sertier Anne-Sophie , Ferrari Anthony , Pommier Roxane M. , Treilleux Isabelle , Boyault Sandrine , Devouassoux-Shisheboran Mojgan , Kielbassa Janice , Thomas Emilie , Tonon Laurie , Le Texier Vincent , Charreton Amandine , Morel Anne-Pierre , Floquet Anne , Joly Florence , Berton-Rigaud Dominique , Ferron Gwenaël , Arnould Laurent , Croce Sabrina , Bataillon Guillaume , Saintigny Pierre , Mery-Lamarche Eliane , Sagan Christine , Senaratne Aruni P. , Gut Ivo G. , Calvo Fabien , Viari Alain , Ouzounova Maria , Ray-Coquard Isabelle , Puisieux Alain
Published: May 2023

Alteration of genes of TP53, PI3K and cell cycle pathways in uterine and ovarian CS.
Figure S4 from Dissecting the Origin of Heterogeneity in Uterine and Ovarian Carcinosarcomas
Authors: Sertier Anne-Sophie , Ferrari Anthony , Pommier Roxane M. , Treilleux Isabelle , Boyault Sandrine , Devouassoux-Shisheboran Mojgan , Kielbassa Janice , Thomas Emilie , Tonon Laurie , Le Texier Vincent , Charreton Amandine , Morel Anne-Pierre , Floquet Anne , Joly Florence , Berton-Rigaud Dominique , Ferron Gwenaël , Arnould Laurent , Croce Sabrina , Bataillon Guillaume , Saintigny Pierre , Mery-Lamarche Eliane , Sagan Christine , Senaratne Aruni P. , Gut Ivo G. , Calvo Fabien , Viari Alain , Ouzounova Maria , Ray-Coquard Isabelle , Puisieux Alain
Published: May 2023

APOBEC-related kataegis event.
Figure S12 from Dissecting the Origin of Heterogeneity in Uterine and Ovarian Carcinosarcomas
Authors: Sertier Anne-Sophie , Ferrari Anthony , Pommier Roxane M. , Treilleux Isabelle , Boyault Sandrine , Devouassoux-Shisheboran Mojgan , Kielbassa Janice , Thomas Emilie , Tonon Laurie , Le Texier Vincent , Charreton Amandine , Morel Anne-Pierre , Floquet Anne , Joly Florence , Berton-Rigaud Dominique , Ferron Gwenaël , Arnould Laurent , Croce Sabrina , Bataillon Guillaume , Saintigny Pierre , Mery-Lamarche Eliane , Sagan Christine , Senaratne Aruni P. , Gut Ivo G. , Calvo Fabien , Viari Alain , Ouzounova Maria , Ray-Coquard Isabelle , Puisieux Alain
Published: May 2023

Complete clonal evolution of P02 tumor.
Figure S1 from A novel class of Ribosome Modulating Agents (RMAs) exploits cancer ribosome heterogeneity to selectively target the CMS2 subtype of colorectal cancer
Authors: Terzo Esteban , Apte Shruti A , Padhye Simran , Rashed Saleh , Austin Wesley , Caponegro Michael , Reddy Anupama , Shi Shuhao , Wang Christy , Clark Roger B , Sidransky David , Modur Vijay , Badarinarayana Vasudeo
Published: May 2023

Imaging assay demonstrating that ZKN-157 inhibits translation of newly synthesized proteins
Data from Phase I Trial of Autologous RNA-electroporated cMET-directed CAR T Cells Administered Intravenously in Patients with Melanoma and Breast Carcinoma
Authors: Shah Payal D. , Huang Alexander C. , Xu Xiaowei , Orlowski Robert , Amaravadi Ravi K. , Schuchter Lynn M. , Zhang Paul , Tchou Julia , Matlawski Tina , Cervini Amanda , Shea Joanne , Gilmore Joan , Lledo Lester , Dengel Karen , Marshall Amy , Wherry E. John , Linette Gerald P. , Brennan Andrea , Gonzalez Vanessa , Kulikovskaya Irina , Lacey Simon F. , Plesa Gabriela , June Carl H. , Vonderheide Robert H. , Mitchell Tara C.
Published: May 2023

Purpose:
Treatments are limited for metastatic melanoma and metastatic triple-negative breast cancer (mTNBC). This pilot phase I trial (NCT03060356) examined the safety and feasibility of intravenous RNA-electroporated chimeric antigen receptor (CAR) T cells targeting the cell-surface antigen cMET.
Experimental Design:
Metastatic melanoma or mTNBC subjects had at least 30% tumor expression of cMET, measurable disease and progression on prior therapy. Patients received up to six infusions (1 × 10e8 T cells/dose) of CAR T cells without lymphodepleting chemotherapy. Forty-eight percent of prescreened subjects met the cMET expression threshold. Seven (3 metastatic melanoma, 4 mTNBC) were treated.
Results:
Mean age was 50 years (35–64); median Eastern Cooperative Oncology Group 0 (0–1); median prior lines of chemotherapy/immunotherapy were 4/0 for TNBC and 1/3 for melanoma subjects. Six patients experienced grade 1 or 2 toxicity. Toxicities in at least 1 patient included anemia, fatigue, and malaise. One subject had grade 1 cytokine release syndrome. No grade 3 or higher toxicity, neurotoxicity, or treatment discontinuation occurred. Best response was stable disease in 4 and disease progression in 3 subjects. mRNA signals corresponding to CAR T cells were detected by RT-PCR in all patients’ blood including in 3 subjects on day +1 (no infusion administered on this day). Five subjects underwent postinfusion biopsy with no CAR T-cell signals seen in tumor. Three subjects had paired tumor tissue; IHC showed increases in CD8 and CD3 and decreases in pS6 and Ki67.
Conclusions:
Intravenous administration of RNA-electroporated cMET-directed CAR T cells is safe and feasible.
Significance:
Data evaluating CAR T therapy in patients with solid tumors are limited. This pilot clinical trial demonstrates that intravenous cMET-directed CAR T-cell therapy is safe and feasible in patients with metastatic melanoma and metastatic breast cancer, supporting the continued evaluation of cellular therapy for patients with these malignancies.
Análise do processo de expansão urbana de Bragança Paulista: o uso e ocupação do solo em microbacias hidrográficas e as geotecnologias
Authors: Cerejo Lucas Nakamura , Bueno Laura
Published: May 2023

Os territórios municipais se alteram constantemente por uma série de fatores, áreas novas passam a ser urbanizadas, enquanto áreas utilizadas são abandonadas iniciando uma recuperação natural. Estes processos consolidam a dinâmica da expansão urbana que se propaga pelos territórios brasileiros. A exploração de áreas rurais e de preservação ambiental para criação de loteamentos no município de Bragança Paulista se mostrou a principal prática do mercado, apoiada pela legislação, gerando inúmeros impactos socioambientais. Este estudo buscou utilizar ferramentas de geotecnologias para compreender de forma quantitativa os impactos no território e analisar os padrões de dispersão dos novos loteamentos urbanos a partir dos limites de cinco microbacias hidrográficas que dividem o território e orientam processos de planejamento do município.
Prova de consideração: dramaturgia e temporalidade não-normativa
Authors: Thürler Djalma
Published: May 2023

O artigo se debruça sobre o texto Prova de consideração, de Gomes Cardim, publicado em 1913 e pretende revelar como o autor pode ser considerado um dos fios invisíveis que contribuiu, à margem dos nomes retidos pela história, para tecer a paisagem teatral daquela época lançando luz sobre muitos temas da história política do século XX que, d’algum modo, refletem ansiedades sociais contemporâneas em torno das mulheres, da sexualidade e do poder nos séculos XIX e início do século XX.
O cânone libertino setecentista, um produto do século XIX português?
Authors: Sousa Rui , Fernandes Manuel P.
Published: May 2023

Bocage e outros poetas contemporâneos cuja obra é considerada representativa da poesia libertina em Portugal tiveram de lidar com os efeitos da censura contínua do seu tempo. Uma boa parte da sua obra circulou clandestinamente ou permaneceu inédita até à primeira metade do século XIX. É nesse contexto que a persistência desses textos e o interesse que despertaram nos poetas e editores oitocentistas conduziram ao aparecimento de algumas obras fundamentais. Neste texto, defende-se a ideia de que a tradição libertina portuguesa setecentista, em termos de integração no cânone literário português, é um produto da dinâmica literária e editorial resultante do triunfo do Liberalismo.
Culinary Diaspora: An Anchor for Indonesian Gastrodiplomacy in the Netherlands
Authors: Yayusman Meilinda Sari , Mulyasari Prima Nurahmi , Trihartono Agus , Gusnelly†
Published: May 2023

Many Indonesian diasporas in the Netherlands have established culinary businesses for both economic purposes and out of a sense of nostalgia for their home country by emphasising Indonesian food authenticity and the richness of spices in their new home. The Netherlands, with its strong historical links with Indonesia, plays a pivotal role in Indonesian gastrodiplomacy. However, the Indonesian government has not yet paid attention to the importance of harnessing the existence of diasporas and targeting the Netherlands as a strategic country of implementation in the context of strengthening Indonesian gastrodiplomacy. This article suggests that Indonesian diasporas, through representation in restaurants, could be a ‘frontline messenger’ in introducing Indonesian foods to the Netherlands and be the anchor of gastrodiplomacy. While Indonesia is now strategising gastrodiplomacy, diasporas are of the utmost importance in winning the hearts and minds of the public.
Salvia cajamarcana (Lamiaceae), a new species from Cajamarca Department, Peru, and lectotypification of S. revoluta
Authors: GONZÁLEZ-GALLEGOS JESÚS GUADALUPE , RONCAL-RABANAL MANUEL , URÍA ROLANDO
Published: May 2023

Recent botanical exploration in the Andes in northwestern Peru has led to the discovery of an undescribed species of Salvia. With 78 species of Salvia, Peru ranks second in Salvia richness among American countries behind only Mexico. The most recent comprehensive revision of Peruvian species dates from 1960, so it is highly probable that an updated revision of the genus in the country would entail the description of several new taxa. Accordingly, we present a diagnosis and description of a new species under the name Salvia cajamarcana. This new species is morphologically most similar to S. revoluta, for which a full revised description is presented to facilitate comparison, as well as the designation of a lectotype. Figures and a distribution map are provided to illustrate the morphology and distribution of the species.
Nicaraven-Loaded Alginate Hydrogels Augment Bone Tissue Repair by Enhancing the Expression Level of Type Collagen Type II and TGF-β Genes; An In Vitro an In Vivo Evaluation
Authors: Song Xiaolei , Yin Shuai , Zhao Feifei , Zhang Wenlu , Rohani Saeed
Published: May 2023

In this research, a composite delivery system was developed by incorporating nicaraven-loaded chitosan nanoparticles into the matrix of alginate-based hydrogels. In Vitro studies including scanning electron microscopy, cell viability assay, cytoprotection assay, cell migration
assay, swelling assay, and drug release assay were performed to characterize the hydrogel system. In Vivo study was performed in a rat model of calvarial bone defect. Histopathological examinations showed that the level of bone tissue repair was significantly higher in nicaraven-delivering
hydrogels compared with other groups. Gene expression studies showed that the developed delivery system enhanced the tissue expression levels collagen type II and TGF-β genes.
Prognostic Value and Immunological Role of the Interleukin 24 Gene in Pan-Cancer Using the Kaplan-Meier Plotter and GEPIA by Genomic Data Commons and R Programming Software
Authors: Peng ChuYu , Zhao Ling , Liao Shengbin , Chen Saiqiong , Bi Yin , Yang Yihua , Qin Aiping , Liu Bo
Published: May 2023

There exists an exclusive cytokine and tumor suppressor gene, which is called Interleukin 24 (IL-24), in interleukin 10 (IL-10) family with antitumor and immune-activating properties. However, pan-cancer analysis of IL-24 for identifying survival prognosis and tumor immune infiltration
level remains lacking. This study utilized multiple online data analysis approaches, including TIMER, Oncomine, GEPIA and the Kaplan-Meier Plotter, for analyzing the differences in expression level, survival and tumor immune infiltration of IL-24 from a pan-cancer perspective. The expression
dissection expounded IL-24 was under conveyed inside brain and prostate cancers, etc., but overexpressed in breast, colorectal and gastric cancers, etc. Also, the survival analysis indicated that IL-24 expression was positively linked to subsisting inside breast carcinoma, sarcoma, and lung
adenocarcinoma, and negatively correlated with stomach adenocarcinoma, kidney renal papillary cell carcinoma, and uveal melanoma. Then, we selected breast cancer and stomach adenocarcinoma as representative cancers for further study and investigation.We found that IL-24 is obviously associated
with the immune cellular infiltration inside breast tumor and stomach adenocarcinoma, where IL-24 is significantly linked to the CD4+ T cell and CD8+ T cell infiltration inside breast cancer. As to the subtypes of breast cancer, IL-24 is evidently linked to CD8+ T cells, B cells and CD4+ T
cells in BRCA-basal and BRCA-luminal subtypes. Furthermore, we discovered that IL-24 expression is negatively associated with the tumor mutation burden (TMB) and that there is a higher survival rate with IL-24 overexpression in breast cancer patients with a low TMB. This finding suggests that
IL-24 can be a substantial biomarker to predict prognostic value and evaluation of infiltrated immune constituents in several cancers.
Recent Research Advancements in Interventions and Assessments Related to Chronic Obstructive Pulmonary Disease Rehabilitation
Authors: Han Bing , Pan Yuming , Li Hua
Published: May 2023

The Global Initiative for Chronic Obstructive Pulmonary Disease states that pulmonary rehabilitation (PR) can improve patients’ health and prevent progression of chronic obstructive pulmonary disease (COPD). By searching the relevant literature on lung ventilation both in China
and abroad, and reviewing the impact of physical exercise, nutrition intervention, physical education, and psychological intervention on lung ventilation measures in COPD patients, this paper aims to provide guidance for clinical nurses in implementing PR in COPD patients.
Soil Moisture Influences on Summer Arctic Cyclones and Their Associated Poleward Moisture Transport
Authors: Fearon Matthew G. , Doyle James D. , Finocchio Peter M.
Published: May 2023

Moisture transport into the Arctic is an important modulator for clouds, radiative forcing, and sea ice change. Transport events—namely, moist-air intrusions—are often associated with Arctic cyclones, and during the summer season we find that the high-latitude land surface is a significant moisture source for intrusions. Summer Arctic cyclones typically originate from the surrounding continental interior and shorelines where during the early stages of intensification the warm sector experiences strong latent heat fluxes from the land surface. In this study, we use multiyear reanalysis data and back-trajectory calculations to quantify the linkages between key continental moisture source regions and water vapor within cyclone-induced intrusions. We also conduct regional soil moisture sensitivity experiments using the Coupled Ocean–Atmosphere Mesoscale Prediction System (COAMPS) to diagnose the land surface moisture contribution for an August 2016 Arctic cyclone case. Results from reanalysis show that land regions on average account for more than 30% of the total moist-air intrusion flux at 70°N during summer. COAMPS case-study experiments reaffirm this result, showing that land surface moisture flux on average accounts for 30% of the intrusion water vapor content. COAMPS experiments further reveal that land surface moisture impacts cyclone intensification and moist-air intrusion cloud water vapor. When the regional soil moisture is reduced, intrusion cloud cover is also reduced, resulting in an increase in the surface solar radiation > 90 W m−2. These results demonstrate that the high-latitude land surface plays an important role in the Arctic summer hydrological cycle and may be increasingly impactful as traditionally cold or frozen soils warm.

Significance Statement

The purpose of this study is to better understand to what extent high-latitude land surface moisture flux is entrained into summer Arctic cyclones and their poleward moisture transport. Moisture transport into the Arctic is important for regional clouds, radiative forcing, and sea ice change. Our results show that land surface evaporation augments cyclone-induced moisture transport into the Arctic on average by 30%. Results are important because traditionally cold or partially frozen high-latitude soils continue to warm and exhibit more positive evaporative trends, including areas undergoing permafrost thaw.
The Tertiary Survey as a Quality Improvement Initiative in Pediatric Trauma Care
Authors: Ulloa Emily , Archie Jessica , Slevakumar Sruthi , Levy Marc , Elkbuli Adel , Plumley Donald
Published: May 2023

Background

Patients are at risk of missed or delayed injuries in the setting of multisystem trauma, which may be identified with a tertiary trauma survey (TTS). There is limited literature to support the utilization of a TTS in pediatric trauma population. We aim to assess the impact of the TTS as a quality and performance improvement tool in identifying missed or delayed injuries and improving the quality of care among pediatric trauma population.

Methods

A retrospective study assessing a quality improvement/performance improvement (QI/PI) project focusing on the administration of tertiary surveys to pediatric trauma patients was conducted at our level 1 trauma center between 08-2020 and 08-2021. Patients with injury severity scores (ISS) greater than 12 and/or an anticipated hospital stay greater than 72 hours met inclusion criteria and were included.

Results

Of the 535 trauma patients admitted to the pediatric trauma service during the study period, 85 (16%) patients met the criteria and received a TTS. Thirteen unaddressed or undertreated injuries were found in 11 patients: 5 cervical spine injuries, 1 subdural hemorrhage, 1 bowel injury, 1 adrenal hemorrhage, 1 kidney contusion, 2 hematomas, and 2 full thickness abrasions. Following TTS, 13 patients (15%) had additional imaging, which identified 6 of the 13 injuries.

Conclusion

The TTS is a valuable quality and performance improvement tool in the comprehensive care of trauma patients. Standardization and implementation of a tertiary survey have the potential to facilitate the prompt detection of injuries and improve the quality of care for pediatric trauma patients.

Level of Evidence

III.
Complicated Diverticulitis and Pelvic Radiation Leading to Colonic Stricture, Colorectal Fistula, and Anal Stenosis
Authors: Pansuriya Shyamal , Ekkel Elisabeth , Pearl Leah , Hain Jon
Published: May 2023

The purpose of this case is to highlight a rare case of sigmoid colon-to-rectum fistula. A 66-year-old man with a history of pelvic radiation and diverticulosis presented to the emergency department with a 3-week history of abdominal pain and watery diarrhea. Computed tomography (CT) imaging was significant for a sigmoid-to-rectum fistula with sigmoid stricture. The patient underwent a laparoscopic colectomy with end colostomy. Pathology revealed perforated diverticulitis. To date, there have been no cases reported in literature describing sigmoid-to-rectum fistula. In conclusion, it is important to consider the development of complex diverticular disease in patients with history of pelvic radiation.
Secondary mental health service utilisation following emergency department contact for suicidal behaviour: A systematic review
Authors: Feng YR , Valuri GM , Morgan Vera A , Preen DB , O’Leary Colleen M , Crampin E , Waterreus A
Published: May 2023

Objective:

Engagement with secondary mental health services after an emergency department presentation with suicidal behaviours may be an important strategy for reducing the risk of repeat attempts. Our aim was to examine secondary mental health service contact following a presentation to emergency department with suicidal behaviours.

Methods:

A systematic review of papers published between 2000 and 2020 was undertaken. This identified 56 papers relating to 47 primary studies. Data were extracted and summarised separately by age group: (1) young people, (2) older adults and (3) adults and studies with participants of ‘all ages’.

Results:

Studies in young people ( n = 13) showed, on average, 44.8% were referred and 33.7% had contact with secondary mental health services within 4 weeks of emergency department discharge. In comparison, in adult/all ages studies ( n = 34), on average, 27.1% were referred to and 26.2% had mental health service contact within 4 weeks. Only three studies presented data on contact with mental health services for older adults, and proportions ranged from 49.0% to 86.0%.

Conclusion:

This review highlights poor utilisation of secondary mental health service following emergency department presentation for suicidal behaviours, and further research is needed to identify the reasons for this. Crucially, this information could assist in the allocation of resources to facilitate the timely implementation of suicide prevention services.
衣食住行 (clothing, food, residence, and mobility) in scholarly practices of Transnational Italian Studies
Authors: Zhang Gaoheng
Published: May 2023

In this article, I explain what the Chinese proverb “clothing, food, residence, mobility” entails, how I use it to broadly frame my current scholarship, what this practice means in relation to my idea of Transnational Italian Studies, the trajectory through which I came to use it, and the potential conceptual problems it may pose. I show that this adoption as an organizing principle of my work shows some decolonizing of the conventions of Italian Studies, which is one direction within Transnational Italian Studies.
Youth voices creating healthy eating and physically active environments in schools
Authors: Shah Smita , Rizzo Liu Kym , Lockett Catriona , Sainsbury Emma
Published: May 2023

Objective:

The objectives of this study were to (1) measure the acceptability of Students As LifeStyle Activists (SALSA) Youth Voices (SYV) programme, (2) determine the skills gained by peer leaders from their participation in SYV and (3) determine whether peer leaders were able to design and implement an action to promote healthy eating and physical activity in their school.

Design:

Process evaluation.

Setting:

Peer leaders (aged 15–16 years) from high schools in Western Sydney, Australia.

Method:

We conducted a process evaluation to determine the reasons why students participated in SYV, which workshop activities they enjoyed, the skills they gained from participating in SYV and whether the actions were designed and implemented. Peer leaders completed an online survey at the end of the Leadership Day. The peer leaders then presented their actions at an SYV Action Day event and completed a further online survey.

Results:

Eighty-four peer leaders from seven high schools in Western Sydney participated in SYV. Peer leaders reported their involvement with the SYV programme as positive, with 68% rating it as ‘very valuable’. Skills gained by the peer leaders included teamwork (90%), communication (85%), leadership (77%) and confidence (65%). Peer leaders planned and devised actions, which included installing water refill stations, fitting the school gymnasium with new equipment, redesigning girls’ sports shorts, and other strategies to engage girls in physical activity. Students from all seven schools presented their actions to receive feedback and expressed confidence that their actions were sustainable.

Conclusion:

The SYV programme showed that providing peer leaders with ownership of their actions was successful in creating healthy school environments, while building leadership, teamwork, communication skills and confidence in adolescents.
Does Level of Social Support During Rejection Affect Pain Sensitivity and Distress?
Authors: Zwolinski Jennifer
Published: May 2023

This study investigated whether level of social support would decrease emotional distress and physical pain sensitivity following rejection. Healthy undergraduate students received varying levels of social support from a close companion during the Partial Future Life Alone rejection paradigm. Participants also completed baseline and post-stressor measures of physical pain sensitivity as well as post-stressor measures of emotional distress. Results indicated that all levels of social support benefited rejected participants by either buffering and/or improving fundamental needs, mood, and pain to levels comparable to non-rejected participants; however, passive support resulted in the fewest beneficial outcomes. The current study provides preliminary evidence that even minimal levels of support during rejection benefits or at least neutralizes associated pain and distress outcomes.
Don Cupitt: prophet, public intellectual and pioneer Public intellectual
Authors: Graham Elaine , Smith Graeme
Published: May 2023

The 1984 BBC TV series The Sea of Faith offered Don Cupitt an exceptional degree of public recognition and notoriety. His advancement of a non-realist and social constructivist theology had a strong polarizing effect on his audience, engendering disapproval and approbation in equal measure. Opinion was strongly divided between those who resisted any kind of critical approach to Christian teaching and those who felt liberated by Cupitt’s call for a more modern and questioning theology. Through archives of audience reactions to his broadcasts and writings, this article considers whether Cupitt’s influence through The Sea of Faith and other writing and broadcasting was sufficient to rank him as a ‘public intellectual’. It will argue that the controversy Cupitt attracted and his categorization as ‘atheist priest’ and ‘radical theologian’ may ultimately have limited his efforts to promote broad-based, serious theological debate in Church and society.
Are Anglican cathedrals more inclusive than parish churches?
Authors: Francis Leslie J.
Published: May 2023

This article argues that, alongside ethnicity, gender and age, psychological type theory offers a distinctive lens through which to assess the inclusivity agenda of the Anglican Church. On this criterion, empirical data indicate that cathedrals are achieving greater inclusivity than parish churches.
The Effect of Perceived Organizational and Supervisory Support on Employee Engagement During COVID-19 Crises: Mediating Effect of Work-Life Balance Policy
Authors: Lee Sang Eun , Shin Geiguen
Published: May 2023

This article examines how organizational and supervisory supports, directly and indirectly, impact employee engagement in U.S. federal agencies during the COVID-19 pandemic. This study applies two analysis models for two different sample groups: federal workers who were required to be physically present at a worksite during the pandemic and those who were not required to do so. Drawing from the sampling frame comprised of “permanently employed, non-political, non-seasonal, full- or part-time federal employees” in pay status as of October 2019, the findings from the U.S. Federal Employment Viewpoint Survey 2020 indicate that organizational and supervisory supports directly impact employee engagement regardless of employees’ work arrangements. However, work engagement is not increased by organizational and supervisory supports that actively encourage employees to use conventional incentives such as work–life balance policies. At the organizational level, this study suggests the need to redesign strategies to motivate public agents to engage in the agency’s mission because conventional and systemic employee support may be ineffective as currently designed. Overall, this study sheds more light on existing studies of public human resource management by examining employee engagement according to work arrangements during the pandemic.
Religion and Pandemic Weight Gain: A Refuge from the Storm?
Authors: Upenieks Laura , Hill Terrence D. , Ford-Robertson Joanne
Published: May 2023

The COVID-19 pandemic was an inherently stressful global crisis that was associated with weight gain for over 40% of the American public. Building on previous research, we draw on recently collected national survey data from the United States to examine the effects of religious attendance (both in-person and virtual), the sense of divine control, and religious/spiritual (R/S) struggles on pandemic weight gain. A series of logistic regression models were conducted. Our findings suggest that divine control and monthly in-person religious attendance were associated with a lower risk of pandemic weight gain, while R/S struggles were associated with a higher risk of weight gain. Our results reveal the complex role that religiosity can play with respect to pandemic weight gain.
Capital Budgeting During Municipal Bankruptcy: Cases of Jefferson County, AL; Central Falls, RI; and Vallejo, CA
Authors: Ermasova Natalia , Guzman Tatyana
Published: May 2023

This comparative case study explores the capital budgeting before, during, and after municipal bankruptcy in three U.S. local governments: Jefferson County, AL; Central Falls, RI; and Vallejo, CA. This in-depth examination of capital budgeting challenges reveals a pattern across all cases—a significant decrease in capital spending on infrastructure and maintenance before and during municipal bankruptcy. In fact, the mismanagement and underinvestment in capital infrastructure were some of the causes of municipal bankruptcy in all three local governments. The comparison of the reforms adopted after the bankruptcy shows that all three local government went through a similar two-stage process of recovery and restructuring, employing the emergent strategy to exit the bankruptcy and the problem-oriented innovative strategy to recover. These results show that even though all three local government significantly decreased spending on capital investments and maintenance as part of the emergent strategy, investment in public infrastructure during the recovery, and reconstructing became a priority across all selected cases.
Relationships among Postpartum Weight Retention, Stress, and Disinhibited Eating: A Scoping Review
Authors: Crossley Nicole P. , Jones Emily J.
Published: May 2023

Postpartum weight retention (PPWR) is a significant contributor to maternal cardiometabolic disease risk. The transition to motherhood is a stressful time period in which women report consuming food to cope, an eating behavior that is associated with PPWR. In this scoping review, we identified original research and review articles published since 2010 that examined relationships among PPWR, maternal stress, and disinhibited eating. In total, 16 articles met the inclusion criteria. Findings were inconsistent related to PPWR and stress. PPWR and disinhibited eating were not significantly correlated; however, disinhibition scores were higher during the postpartum period compared to prenatally. Stress and disinhibited eating were directly correlated in 4 studies. Our findings suggest these concepts, particularly disinhibited eating, have not been robustly examined during the postpartum period. Additionally, instruments used to measure maternal stress vary widely and should be further studied and refined.
The Curvilinear Role of Trust in Marketing Systems: Analysis of a Moderated-Mediation Model with Hierarchical Linear Modeling
Authors: Manis Kerry T. , Cockrell Seth , Friske Wesley
Published: May 2023

Trust has long been recognized as an important component of marketing systems. However, while macromarketing researchers argue that a lack of trust in business can impact other components of marketing systems, very few empirical studies in marketing investigate the determinants or outcomes associated with this type of trust. Accordingly, we begin with the premise that trust in major corporations is a critical, micro-level attitude that affects the performance of a marketing system. Then, we investigate the factors that influence trust in major corporations by analyzing how perceptions of government involvement in business, political ideology, and other attitudinal and demographic variables affect trust. Using hierarchical linear modeling, we find that trust has a curvilinear relationship with perceptions of free-market competition, in which too much trust, or too little, leads to negative perceptions - trust plays a critical mediating role in constructing beliefs about free markets. Additionally, we show that macroeconomic variables influence the first stage of attitude formation toward major corporations, with gross domestic product (GDP) per capita and foreign direct investment (FDI) acting as moderators in our analysis. Overall, the multi-level moderated-mediation model used in this research embodies a true systems approach to the analysis of marketing systems by demonstrating how the economic outcomes of marketing systems (e.g., GDP and FDI) can also have feedback effects on participants within a marketing system.
Measuring Value Created for and by Stakeholders
Authors: Sugai Philip , Mahajan Gautam
Published: May 2023

This paper outlines how value can be measured across four elements of the firm/stakeholder relationship beyond standard economic measures. It takes into account the perception of financial value along with non-financial benefits provided and received by the firm and its stakeholders. Focusing only upon the economic or financial outcomes of such relationships can lead to erroneous results as the money spent may not create value for the receiver, and could even do significant harm. The aggregation of views across different firms together with the perceptions of various stakeholders will allow for comparisons between firms and stakeholders. Applying this conceptual model will also reveal what is important to the firm versus what is important to the stakeholder. This paper proposes an improved approach to conceptualizing and measuring net value in which businesses can see if the value they provide exceeds the value they receive from stakeholders and vice versa.