bluuebunny/crossref_metadata_2025 huggingface dataset:
İhracat Yapan İşletmelerin Dinamik Yeteneklerinin İşletme Performasına Etkisinde Örgütsel Çevikliğin Aracılık Rolü (Halıcılık Sektöründe Gaziantep İli Örneği)
Authors: KÜÇÜKLER Mine , YILDIRIM İbrahim
Published: August 2022

Çalışmanın amacı dinamik yetenekler ve işletme performansı arasındaki ilişkiyi anlamak ve bu ilişkideki örgütsel çevikliğin aracılık rolünü incelemektir. Çalışma örgütsel çevikliğin dinamik yetenekler ve işletme performansı ilişkisine pozitif yönlü etki edeceğini varsaymakta ve bu doğrultuda dinamik yetenekler ile işletme performansı arasındaki ilişkiyi araştırmaktır. Kolayda örnekleme yöntemi kullanılarak işletmelerin üst düzey yöneticileri/sahiplerine anket uygulanmıştır. Elde edilen veriler SPSS ve MPlus istatistik paket programları kullanılarak, yapısal eşitlik modellemesi aracılığıyla analiz edilmiştir. Bu analizler sonucunda elde edilen bulgular dinamik yetenekler ve işletme performansı ilişkisine örgütsel çevikliğin öngörülen aracılık etkilerini desteklemektedir. Örgütsel çeviklik algısı ne kadar yüksek olursa dinamik yetenekler ve işletme performansı arasındaki ilişki pozitif yönlü arttığını ortaya koymaktadır. Bu bulgular özellikle rekabetin yoğun olarak yaşandığı halıcılık sektöründe işletmelerin rakiplerine karşı avantaj elde etmeleri ve bu avantajı sürdürebilmeleri açısından büyük önem taşımaktadır. Çalışmanın sonunda, bu bulguların hem teoriye hem de uygulamaya yönelik katkılar sunması beklenmektedir.
Humanitárius fejlesztés vagy kulturális imperializmus?
Authors: Molnár Zsolt
Published: August 2022

A nemzetközi önkéntesség kiemelt szerepet játszik a nemzetközi fejlesztésben, mivel interkulturális közvetítő intézményként működik a küldő és a fogadó országok és közösségek között, biztosítva a humanitárius és fejlesztési programok megvalósításához szükséges humán kereteket. A nemzetközi önkéntesség leggyakrabban nemzetközi NGO-k és transznacionális szervezetek (pl. ENSZ, EU) célkitűzései alapján a humanitárius programokat alakítja helyi fejlődéssé a tevékenységek helyi koordinálásán, tudástranszferen, képzéseken és az önkéntesek fizikai munkavégzésén keresztül. Tanulmányomban a nemzetközi önkéntesség interkulturális sajátosságait, összetevőit és hatásait vizsgáltam meg 21 visszatért magyar nemzetközi önkéntes személyes tapasztalatain keresztül. Kutatói célom annak feltárása, hogy mennyire felel meg a magyar önkéntesség a vele szemben támasztott új kihívásoknak. A résztvevőkkel felvett szakmai mélyinterjúk négy kérdéskört érintettek, az 1) interkulturális szempontok megjelenése az önkéntesek motivációjában, a 2) megtapasztalt helyi szokások és nehézségek azonosítása és kezelése, a 3) kulturális imperializmus jelenléte, valamint az 4) önkéntesség fogadó félre gyakorolt hatásának értékelése. A vizsgálat legfontosabb megállapítása, hogy a magyar önkéntesek jelentős része tudatosan készült és kezelte az interkulturális kihívásokat, és részben felismerték saját kulturális felelősségüket is. Főleg a magyar kezdeményezésű fejlesztési projektek helyeztek nagy hangsúlyt az interkulturális előkészítésre és a helyi elvárásoknak való megfeleltetésre.
TINJUAN TEORITIS PERIZINAN JUAL BELI CAIRAN ROKOK ELEKTRIK DI HUBUNGAN DENGAN UNDANG-UNDANG NOMOR 7 TAHUN 2014 TENTANG PERDAGANGAN
Authors: Prayitno Anggi Ariyadi , Junawan Jojo
Published: August 2022

Indonesia merupakan salah satu negara dengan jumlah perokok yang cukup besar. Sesuai perkembangan zaman, bentuk rokok yang diminat para remaja, yaitu penggunaan rokok elektrik (Electronic Nicotine Delivery System atau E-Cigarette). Rokok elektrik sendiri juga sudah terdapat di Indonesia. Sampai saat ini, rokok elektrik masih masuk ke Indonesia sebagai komoditi perdagangaan alat elektronik lainnya, bukan sebagai rokok atau obat-obatan. Akibatnya rokok elektrik ini tidak memiliki izin dari Kementrian Perdagangan dan tidak ada izin edar dari BPOM serta bebas dari cukai. Seperti yang kita tahu, jaman sekarang ini vape sudah banyak mengalami perkembangan yang bisa dibilang cukup pesat dan juga menjadi perdebatan yang ada terutama khususnya di Indonesia. Dalam penelitian ini permasalahan yang ingin diketahui ialah 1) Bagaimanakah pelaksanaan peredaran cairan rokok elektrik di wilayah Kota Cirebon, 2) Bagaimanakah upaya Dinas Perdagangan dalam menertibkan peredaran cairan rokok elektrik. Penelitian ini merupakan metode pendekatan yuridis empiris yang merupakan pemecahan masalah yang didasarkan pada studi pustaka atau peraturan perundang- undangan yaitu Undang-Undang Nomor 7 Tahun 2014 Tentang Perdagangan dengan maksud dan tujuan menemukan fakta yang menuju pada identifikasi masalah dan pada akhirnya penyeselasaian masalah. Dalam hal pendekatan digunakan untuk menganalisa Dinas Peindustrian dan Perdagangan (DISPERDAGIN) Kota Cirebon dalam perannya untuk meminimalisir peredaran cairan rokok elektrik (liquid) yang beredar dan belum memiliki izin di wilayah Kota Cirebon. Hasil penelitian disimpulkan bahwa tidak adanya perizinan yang dimiliki oleh para penjualnya cairan rokok elektrik (liquid) diwilayah Kota Cirebon namun banyak penjual yang menjual produk tersebut secara bebas tanpa memiliki izin. Dari sini Dinas Perdagangan Kota Cirebon memiliki upaya-upaya sendiri dari melakukan pengawasan, menetapkan standar, mengadakan tindakan penilaian, mengadakan tindakan perbaikan dan mereka tidak segan untuk melakukan penyitaan terhadap produk tersebut jika melanggar Undang-Undang yang berlaku.
AKIBAT HUKUM PERALIHAN HAK ATAS TANAH BERDASARKAN SPPT PBB (Study di Badan Pertanahan Naional Kabupaten Kuningan)
Authors: Akbar Hari Hariman Maulana , Lambok Betty Dina
Published: August 2022

Tanah merupakan suatu bagian dari unsur Negara, yang menjadi suatu faktor terpenting dalam kehidupan manusia, maka dari itu pendaftaran tanah sangat lah penting sebgai tanda bukti kepemilikan hak atas tanah yang memiliki kepastian hukum dengan diterbitkannya suatu sertifikat hak atas tanah. Penerbitan sertifikat hak atas tanah ini dapat dilakukan dengan melengkapi dokumen- dokumen yang telah diatur dalam peraturan Perundang-Undangan, dalam proses peralihan hak sering terjadi dokumen-dokemen yang tidak lengkap, karena masih banyak yang menggap bahwa dengan memiliki Surat Pemberitahuan Pajak Terutang Pajak Bumi dan Bangunan (SPPT PBB) sudah memiliku kekuatan hukum dan dengan adanya SPPT PBB dapat melakukan peralihan hak, tetapi dalam prosesnya SPPT PBB ini merupakan salah satu syarat yang wajib ada dalam peralihan hak, Karena SPPT PBB ini merupakan suatu bukti pembayaran pajak atas tanah tersebut. Penelitian ini bertujuan untuk mengetahui perlindngan hukum terkait peralihan hak atas tanah yang didasrkan oleh SPPT PBB serta unuk mengetahui akibat hukum dari penerbitan sertifikat peralihan hak atas tanah berdasarkan SPPT. Metode penelitian yang digunakan dalam penelitian ini ialah yuridis normatif yaitu suatu penelitian hukum yang dilakukan dengan meneliti bahan kepustakaan atau bahan sekunder sebagai bahan dasar untuk diteliti dengan cara mengadakan penelusuran terhadap peraturan-peraturan dan literatur yang berhubungan dengan permasalahan yang diteliti. Hasil dari penelitian ini menunjukan bahwa secara umum proses peralihan hak atas tanah dapat diperoleh dengan berbagai cara seperti peralihan hak atas tanah berdasarkan jual beli, hibah dan pewarisan serta dalam proses peralihannya itu harus didasarkan dengan bukti yang kuat dan telah melengkapi dokumen yang telah ditentukan. Peralihan hak yang berdasarkan bukti kepemilikannya berupa SPPT PBB tidak bisa dilakukan karena dalam peraturannya SPPT ini marupakan salah satu syarat yang wajib ada dalam peralihan karena membuktikan pembayaran pajak atas tanah tersebut, dan jika meihat dari peraturannya persyaratan yang lebih utamanya itu dengan adanya sertifikat tanah sebagai bukti sah kepemilikan atas tanah, jika tetap diterbitkannya sertifikat peralihan yang hanya didasarkan bukti kepemilikannya berupa SPPT saja itu telah melanggar peraturan pendaftaran tanah dan akan berakibat hukum.
PERTANGGUNGJAWABAN PIDANA DEBT COLLECTOR YANG MELAKUKAN TINDAK PIDANA PERAMPASAN DALAM KREDIT BERMASALAH
Authors: Handayani Prika , Asmara Teddy
Published: August 2022

Kasus penagihan hutang terhadap debitur oleh kreditur dengan memakai penagih hutang (debt collector) dalam menagih hutang dengan cara paksaan. Meskipun demikian, kasus perampasan yang dilakukan debt collector di jalan masih marak terjadi khususnya di Kota Cirebon.Sehingga perlu diketahui sejauhmana pertanggungjawaban debt collector yang melakukan tindak pidana dengan merampas paksa kendaraan yang mengalami kredit bermasalah. Rumusan masalah dalam penelitian ini adalah Bagaimana pertanggungjawaban pidana Debt Collector yang melakukan perampasan atas kendaraan sebagaimana menjadi obyek perjanjian Leasing dalam kredit bermasalah dan Bagaimanakah status kendaraan milik konsumen yang menjadi objek perampasan yang dilakukan oleh Debt collector. Metode Penelitian dengan pendekatan Yuridis Normatif, yaitu pendekatan yang berusaha menelusuri mengenai tindak pidana yang dilakukan oleh Debt Collector dalam hal melakukan perampasan kendaraan bermotor milik konsumen dalam kredit bermasalah serta pertanggungjawaban pidananya dari sudut pandang normatif dan mengkajinya berdasarkan ketentuan peraturan perundang-undangan yang berlaku. Penelitian menghasilkan bahwa debt collector yang melakukan penarikan paksa dengan kekerasan wajib mempertanggungjawabkan perbuatannya secara pidana yang mana pertanggungjawabannya diatur di dalam KUHP. Kasus ini sudah melanggar ketentuan di dalam Pasal 365 ayat (1) Jo Pasal 365 ayat (2) ke-2 Jo Pasal 53 KUHP dan Pasal 55 KUHP Ayat 1 angka 1 dan 2. Sedangkan proses penarikannya menurut Peraturan Kapolri Nomor 8 Tahun 2011, satu-satunya pihak yang berhak menarik kendaraan kredit bermasalah adalah kepolisian. Pasal 8 Peraturan Kepala Kepolisian Negara Republik Indonesia menyebutkan syarat-syarat administrasi yang harus dilampirkan olehperusahaan pembiayaan konsumen untuk antara lain salinan akta jaminan fidusia, salinan sertifikat fidusia, surat peringatan kepada debitur untuk memenuhi kewajibannya, identitas pelaksana eksekusi, dan surat tugas pelaksanaan eksekusi. Surat peringatan kepada debitur yang dibuktikan dengan tanda terima. debt collector yang melakukan penarikan paksa dengan jalan ancaman dan kekerasan kepada konsumen harus dipertanggungjawabkan secara pidana. Seharusnya pihak debt collector lebih memperhatikan tindakannya apabila menjalankan tugasnya, jangan melakukan penarikan secara paksa dengan jalan kekerasan yang bersifat merugikan pihak konsumen.
REPOSISI KEBIJAKAN PEMULIHAN LINGKUNGAN HIDUP TERHADAP PENAMBANGAN ILEGAL GALIAN C
Authors: Ariadica Anggie Aqila , Sutrisno Endang , Dimyati Agus
Published: August 2022

Pembangunan memiliki banyak ekses dalam kehidupan diantaranya mengandung risiko degradasi kualitas lingkungan hidup. Dibutuhkan kebijakan untuk menjaga keseimbangan antara pembangunan dengan kelestarian lingkungan hidup. Kegiatan penambangan Galian C yang telah berlangsung lama telah menegasikan kelestarian lingkungan hidup, peran kebijakan Pemerintah Daerah melalui green policy menjadi alternatif yang dibutuhkan untuk mengatasi problem tersebut. Riset ini menggunakan pendekatan doktrinal dalam upaya memahami serta mengkaji ketentuan hukum Undang-Undang Nomor 32 Tahun 2009 tentang Perlindungan dan Pengelolaan Lingkungan Hidup, sebagai pijakan dasar untuk menempatan kembali kebijakan yang telah ada pada posisi keberpihakan terhadap upaya perlindungan serta pelestarian lingkungan. Degradasi lingkungan akibat kegiatan penambangan yang dilakukan secara terus-menerus tanpa henti, membutuhkan upaya-upaya pemulihan lingkungan hidup ntuk mengembalikan fungsi lahan dalam perspektif sustainable development. Reposisi kebijakan menjadi sebuah keniscayaan yang harus dilakukan Pemerintah Daerah dengan memanfaatkan kembali lahan bekas Galian C untuk mengembangkan perekonomian masyarakat sekitar kawasan, misalnya untuk destinasi wisata. Tatanan norma hukum telah memberikan alternatif peluang pengembangan kawasan tersebut melalui ketentuan Undang-Undang Nomor 4 Tahun 2009 tentang Pertambangan Mineral dan Batubara. Konstruksi kebijakan harus dikembalikan kepada formulasi ketaatan pada asas pemulihan lingkungan melalui kegiatan pascatambang lahan bekas Galian C, berbasis penguatan pemulihan nilai-nilai ekonomi kerakyatan masyarakat kawasan.
KEKUATAN AKTA JUAL BELI (AJB) ATAS TANAH DALAM PROSES MENJADI SERTIPIKAT HAK MILIK (SHM)
Authors: Dewi Yeni Puspita , Marlina Tina , Maulida Irma
Published: August 2022

Tanah.merupakan.salah.satu.sumber.penghidupan bagi masyarakat dan menjadi kebutuhan manusia yang mendasar, tanah dan manusia tidak dapat dipisahkan. Manusia hidup dan berkembang serta melakukan aktivitas di atas tanah. Pasal 9 Undang-Undang Pokok Agraria dan Peraturan dan Peraturan Pemerintah No. 24 Tahun 1997 tentang Pendaftaran Tanah menjelaskan bahwa adanya kepastian hukum yang dilaksanakan oleh Pemerintah. Pemerintah harus menyelenggarakan pendaftaran atas tanah guna membuktikan tanda kepemilikan, hal ini dimaksudkan supaya terciptanya ketertiban atas pemanfaatan tanah. Berdasarkan latar belakang masalah tersebut maka identifikasi masalah ini adalah Bagaimana kekuatan akta jual beli (AJB) dalam pensertipikatan tanah dan Bagaimana proses akta jual beli (AJB) menjadi sertipikat hak milik (SHM). Dalam penelitian ini metode penelitian yang digunakan adalah metode pendekatan yuridis normatif, yaitu suatu penelitian yang memiliki maksud dan tujuan untuk menemukan fakta, yang kemudian munuju pada identifikasi dan pada akhirnya menuju penyelesaian masalah. Hasil penelitian dan merupakan sebagai tujuan akhir dari pembuatan akta tanah yaitu untuk mendapatkan sertipikat sebagai. Penjaminan hak atas tanah tersebut yaitu dikarenakan adanya sertipikat atas tanah karena yang telah dilengkapi dengan surat ukur mengenai batas-batas tanah secara pasti sehingga dapat menjamin kepastian objeknya.
Türkiye’nin Jeopolitiği
Authors: DOĞAN Mesut , SERTKAYA DOĞAN Özlem
Published: August 2022

Dünyada ortaya çıkan siyasi, ekonomik krizler; terör ve salgın olayları ülkeleri olumsuz etkilemektedir. Bu olaylarda köprü vazifesi gören transit geçiş merkezleri daha fazla etkilenirler. Bu bağlamda Türkiye, konumuna bağlı olarak meydana gelebilecek olaylardan çok fazla zarar görmektedir. Türkler; 1071 yılında Anadolu’ya gelmiş, bu topraklarda yerleşmiş, siyasi bakımdan güçlü, kadim, faziletli devletler ve imparatorluklar kurmuşlardır. Devletlerin kurulması ve gelişmesinde etkili olan önemli unsurların başında coğrafi konum ve doğal-beşeri özellikler gelmektedir. Türkiye, stratejik konumu nedeniyle yakın ve uzak bölgesinde meydana gelen tüm olaylardan etkilenen, diğer taraftan da önemli aktör olarak olaylara müdahil olan bir ülkedir. Türkiye, uluslararası önemli ulaşım yolları üzerinde bulunması ve çevre ülkeleri birbirine bağlayarak tüm yolların buluşma noktasında olması nedeniyle Asya ve Avrupa’nın ana eksenini de oluşturmaktadır. Bu özellik nedeniyle Türkiye, hem uluslararası ticaretin hem de küresel güvenliğin önemli merkezlerinden biri olmuştur. Bunun en güzel örnekleri Balkanlar, Kafkaslar ve Ortadoğu’da meydana gelen savaş ve olaylardan görülmektedir. Yine Rusya - Ukrayna Savaşı’nda arabuluculuk çalışmaları ve gıda tedariki noktasında da Türkiye’nin rolü dikkat çekmektedir. Türkiye’nin bulunduğu konumunun önemi; Haçlı Seferleri’nde, Osmanlı Dönemi’nde, 1. Dünya, Kurtuluş ve 2. Dünya Savaşları’nda açıkça ortaya çıkmıştır. Cumhuriyetin ilanıyla tüm dünyaya gücünü göstermeye çalışan, soğuk savaş döneminde etkinliğini gösteren ve yenidünya düzeninde daha da öne çıkan bir Türkiye, jeopolitik özellikleriyle varlığını her zaman devam ettirecektir.
Single-target detection of Oncomelania hupensis based on improved YOLOv5s
Authors: Fang Juanyan , Meng Jinbao , Liu Xiaosong , Li Yan , Qi Ping , Wei Changcheng
Published: August 2022

To address the issues of low detection accuracy and poor effect caused by small Oncomelania hupensis data samples and small target sizes. This article proposes the O. hupensis snails detection algorithm, the YOLOv5s-ECA-vfnet based on improved YOLOv5s, by using YOLOv5s as the basic target detection model and optimizing the loss function to improve target learning ability for specific regions. The experimental findings show that the snail detection method of the YOLOv5s-ECA-vfnet, the precision (P), the recall (R) and the mean Average Precision (mAP) of the algorithm are improved by 1.3%, 1.26%, and 0.87%, respectively. It shows that this algorithm has a good effect on snail detection. The algorithm is capable of accurately and rapidly identifying O. hupensis snails on different conditions of lighting, sizes, and densities, and further providing a new technology for precise and intelligent investigation of O. hupensiss snails for schistosomiasis prevention institutions.
Structural lubricity of physisorbed gold clusters on graphite and its breakdown: Role of boundary conditions and contact lines
Authors: Gao Hongyu , Müser Martin H.
Published: August 2022

The sliding motion of gold slabs adsorbed on a graphite substrate is simulated using molecular dynamics. The central quantity of interest is the mean lateral force, that is, the kinetic friction rather than the maximum lateral forces, which correlates with the static friction. For most setups, we find Stokesian damping to resist sliding. However, velocity-insensitive (Coulomb) friction is observed for finite-width slabs sliding parallel to the armchair direction if the bottom-most layer of the three graphite layers is kept at zero stress rather than at zero displacement. Although the resulting kinetic friction remains much below the noise produced by the erratic fluctuations of (conservative) forces typical for structurally lubric contacts, the nature of the instabilities leading to Coulomb friction could be characterized as quasi-discontinuous dynamics of the Moiré patterns formed by the normal displacements near a propagating contact line. It appears that the interaction of graphite with the second gold layer is responsible for the symmetry break occurring at the interface when a contact line moves parallel to the armchair rather than to the zigzag direction.
Informality, violence, and disaster risks: Coproducing inclusive early warning and response systems in urban informal settlements in Honduras
Authors: Peters Laura E. R. , Clark-Ginsberg Aaron , McCaul Bernard , Cáceres Gabriela , Nuñez Ana Luisa , Balagna Jay , López Alejandra , Patel Sonny S. , Patel Ronak B. , Van Den Hoek Jamon
Published: August 2022

Anticipatory disaster risk reduction (DRR) is an essential human right for the ~1 billion people living in informal settlements who are disproportionately exposed to climate-related hazards due to their high vulnerability. Participatory approaches are recognized as being critical for effective and sustainable disaster prevention, mitigation, and preparation through to response, but research on how to coproduce anticipatory DRR with people living and working in informal settlements is scant. Their exclusion is even more pronounced in challenging contexts, such as those characterized by social-political fragility and violence. As a result, a significant portion of the global population is left behind in best practices tied to global DRR ambitions, with DRR actions working neither with nor for the people most at risk. The signal case of urban informal settlements controlled by territorial gangs in Tegucigalpa, Honduras, illustrates the need for new thinking on how to inclusively mitigate, prepare for, and respond to natural hazard-related disasters. Our research examines the coproduction of early warning systems linked with response capacities for floods and landslides through the case study of the international NGO GOAL's work across the city with a focus on nine urban informal settlements with high levels of territorial gang violence. We explore how GOAL navigated informality and violent conflict to support the early warning and response system as an inclusive social process rather than a technical exercise. We identify four cross-cutting strategies employed by GOAL in support of local vulnerability reduction and capacity building based on a local systems approach. This research breaks new ground in identifying how to bridge the gap between knowledge and action in designing inclusive and sustainable early warning and response systems together with the millions of people around the world affected by the intersection of informality, violence, and disaster risks.
Case report: Spontaneous coronary artery dissection in a man with Ehlers–Danlos syndrome
Authors: Li Qiao , Ma Min , He Yong
Published: August 2022

Background

Spontaneous coronary artery dissection (SCAD), as a medical emergency, represents one of the non-atherosclerotic causes of an acute coronary syndrome (ACS). It often occurs in young and middle-aged females and is a rarity among male patients. Yet, it is easily misdiagnosed or missed even though it has one of the highest in-hospital mortality rates.

Case summary

Here, we present a young male patient admitted to the emergency department of our hospital due to a complaint of acute chest pain. During his hospitalization, we utilized several tools, including imaging modalities, genetic analyses, and clinical strategies, to ensure a proper diagnosis and management of the patient. The results indicated that the patient suffered from SCAD, as well as vascular Ehlers–Danlos syndrome (vEDS). Unfortunately, the patient died of SCAD-related sudden cardiac death (SCD) on the ninth day before the DNA analysis results were obtained. Despite a global effort and huge progress in the clinical characterization of SCAD, as well as patients’ assessments, its pathophysiology remains poorly understood, with a significant recurrence risk and no specific disease-modifying therapy.

Conclusion

Vascular Ehlers–Danlos syndrome, as an inherited connective tissue disorder characterized by congenital connective tissue dysplasia, is a rare and particularly challenging monogenetic disease. It can cause life-threatening changes, including arterial dissections and ruptures, and lead to early death due to COL3A1 pathogenic variants. It is also a rare cause of SCAD. Currently, the gold standard for SCAD diagnosis is coronary angiography (CAG).
Optimal dose of tirzepatide for type 2 diabetes mellitus: A meta-analysis and trial sequential analysis
Authors: Yu Yunfeng , Hu Gang , Yin Shuang , Yang Xinyu , Zhou Manli , Jian Weixiong
Published: August 2022

Objective

The purpose of this study is to evaluate the optimal dose of tirzepatide (TZP) for the treatment of type 2 diabetes mellitus (T2DM) by meta-analysis and trial sequential analysis (TSA).

Methods

Clinical trials of TZP for T2DM were obtained by searching 8 databases with a time limit from database creation to May 2022. Mean differences (MD) and 95% confidence intervals (95%CI) were used for continuous variables, and relative risk (RR) and 95%CI were used for dichotomous variables.

Results

Compared with TZP 5 mg, meta-analysis showed that TZP 10 mg significantly reduced glycosylated hemoglobin type A1c (HbA1c) (MD −0.24, 95%CI −0.31~-0.17, P < 0.00001), fasting serum glucose (FSG) (MD −5.82, 95%CI −8.35~-3.28, P < 0.00001) and weight (MD −2.47, 95%CI −2.95~-1.98, P < 0.00001), and TZP 15 mg significantly reduced HbA1c (MD −0.37, 95%CI −0.44~-0.29, P < 0.00001), FSG (MD −8.52, 95%CI −11.07~-5.98, P < 0.00001) and weight (MD −4.63, 95%CI −5.45~-3.81, P < 0.00001). Compared with TZP 10 mg, TZP 15 mg dramatically reduced HbA1c (MD −0.12, 95%CI −0.19~-0.05, P = 0.001), FSG (MD −2.73, 95%CI −5.29~-0.17, P = 0.04) and weight (MD −2.18, 95%CI −2.67~-1.70, P < 0.00001). The TSA indicated that the benefits observed in the current information set were conclusive, except for the FSG of “TZP 15 mg vs. TZP 10 mg”. In terms of safety endpoints, meta-analysis revealed that there was no significant difference in the serious adverse events (AEs), major adverse cardiovascular events-4 (MACE-4), cardiovascular death, hypertension, cancer and hypoglycemic of the three dose groups of TZP. Compared with TZP 5 mg, TZP 10 mg increased total adverse events (RR 1.06, 95%CI 1.01~1.11, P = 0.03) and gastrointestinal (GI) AEs (RR 1.17, 95%CI 1.03~1.33, P = 0.02), and TZP 15 mg increased total AEs (RR 1.10, 95%CI 1.05~1.15, P = 0.0001). There were no significant differences in total AEs and GI AEs for TZP 15 mg compared to TZP 10 mg. The TSA demonstrated that the total AEs of “TZP 15 mg vs. TZP 5 mg” were conclusive.

Conclusions

TZP 15 mg >TZP 10 mg > TZP 5 mg in terms of lowering glycemia and reducing weight. TZP 5 mg > TZP 10 mg = TZP 15 mg in terms of safety. On this basis, we recommend TZP 5 mg as the first-choice dose for patients with T2DM to minimize AEs while reducing glycemia and weight. If patients cannot effectively control their glycemia after taking TZP 5 mg, it is recommended to take TZP 15 mg directly to achieve the best effect of glycemic reduction. However, most of the included studies have the background of basic medication, the independent efficacy and safety of different doses of TZP still need to be tested.

Systematic review registration

Unique Identifier: CRD42022341966.
Long-term use of renin-angiotensin-system inhibitors after acute myocardial infarction is not associated with survival benefits: Analysis of data from the Korean acute myocardial infarction registry-national institutes of health registry
Authors: Park Chan Soon , Yang Han-Mo , Kang Jeehoon , Han Jung-Kyu , Park Kyung Woo , Kang Hyun-Jae , Koo Bon-Kwon , Seung Ki-Bae , Cha Kwang Soo , Seong In-Whan , Rha Seung-Woon , Jeong Myung Ho , Kim Hyo-Soo
Published: August 2022

Introduction

Renin-angiotensin-system inhibitors (RASi) have shown survival benefits after acute myocardial infarction (MI), but the role of routine long-term use of RASi remains unclear. Thereby, we explored the therapeutic effects of RASi medication at 1-year follow-up from acute MI.

Methods

Using the nationwide Korea Acute Myocardial Infarction Registry-National Institutes of Health (KAMIR-NIH) registry, we included and analyzed 10,822 subjects. Patients were stratified into those taking RASi at 1-year follow-up (n = 7,696) and those not taking RASi at 1-year follow-up (n = 3,126). Patients were followed up for 2-years from the 1-year follow-up; 2-year all-cause mortality and cardiac mortality were analyzed as primary and secondary outcomes, respectively.

Results

The use of RASi at 1-year follow-up was not associated with decreased all-cause mortality (log-rank P = 0.195) or cardiac mortality (log-rank P = 0.337). In multivariate analyses, RASi medication at 1-year follow-up did not reduce all-cause mortality (P = 0.758) or cardiac mortality (P = 0.923), while RASi medication at discharge substantially reduced 1-year all-cause and cardiac mortality. Treatment with either an angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker at 1-year follow-up did not show survival benefits from 1-year follow-up, respectively. The use of RASi at 1-year follow-up did not show a prognostic interaction between previous history of chronic kidney disease, post-MI acute heart failure, concomitant use of beta-blockers at 1-year follow-up, or 1-year LVEF.

Conclusion

Acute MI patients taking RASi at 1-year follow-up were not associated with improved 2-year all-cause mortality or cardiac mortality from the 1-year follow-up. This study provides valuable information regarding tailored medication strategy after acute MI.

Clinical trial registration

[www.ClinicalTrials.gov], identifier [KCT0000863].
Evaluation of organic geochemical characteristics and experiments of thermal pressure simulation of Jurassic coal measure source rocks in the Yanqi Basin
Authors: Yao Yaming , Zhao Fei , Zhang Junmin , Zhao Juanjuan
Published: August 2022

The Yanqi Basin is a coal-bearing basin in Western China. In order to determine the hydrocarbon generation potential of the Jurassic source rocks in this area, the organic matter composition of coal-measure mudstone, carbonaceous mudstone and coal rocks, the yields of liquid and gaseous hydrocarbons, and the comparison of hydrocarbon sources were studied by means of hydrocarbon-generating thermal simulation experiments. The results showed that the micro-composition of the Jurassic coal rocks in the Yanqi Basin showed the characteristics of rich vitrinite-inertinite and poor chitinite + saprolite components; however, the micro-composition of the mudstone showed the characteristics of poor inertinite and rich vitrinite–chitinite + saprolite components. The Jurassic mudstone has a wide distribution range of hydrogen and oxygen indexes, among which the hydrogen index is distributed between 2 and 266 mg/gTOC, and the oxygen index is distributed between 3 and 183 mg/g TOC. The organic matter in the mudstone belongs to Type II2-III kerogen. The hydrogen index of coal is distributed in the range of 100–300 mg/gTOC, which is obviously larger than that of mudstone. The total liquid hydrocarbon yield of the coal rock is the highest (43.2 mg/gTOC), followed by mudstone (16.4–20.4 mg/gTOC), while that of the carbonaceous mudstone is the lowest (5.36 mg/gTOC). In addition, mudstone has the highest yield of gaseous hydrocarbons, followed by coal, while that of carbonaceous mudstone is the lowest. The oil-source comparison showed that the Jurassic crude oil has a certain affinity with its main source rocks (mudstone, carbonaceous mudstone, and coal). At the same time, the comparison results of steroid and terpene biomarker parameters with crude oil showed that the Middle and Lower Jurassic mudstone, carbonaceous mudstone, and coal rock in this area are all source rocks and the Badaowan Formation mudstone is the main hydrocarbon source.
Anti-Mullerian Hormone (AMH) and adenomyosis: Mini-review of literature of the last 5 years
Authors: Gulino Ferdinando Antonio , Dilisi Valentina , Capriglione Stella , Cannone Francesco , Catania Francesco , Martire Francesco Giuseppe , Tuscano Attilio , Gulisano Marianna , D’Urso Valentina , Di Stefano Alessandra , Cimino Monia Caterina , Filippini Maurizio , Latella Silvia , Sammarini Margaret , Musmeci Giulia , Palumbo Marco Antonio
Published: August 2022

Introduction

Adenomyosis is a form of endometriosis characterized by the presence of endometrial tissue in the myometrium. The correlation between anti-Mullerian hormone (AMH) expression and adenomyosis is unclear. Few studies investigated this possible correlation with promising results. The aim of this mini-review is to illustrate the potential prognostic and therapeutic role of AMH in adenomyosis.

Materials and methods

A study protocol was completed conforming to the Preferred Reporting Items for Reviews and Meta-Analyses (PRISMA) guidelines for systematic reviews. We performed an electronic databases search from each database’s inception from August 2017 to August 2022 for full-text articles and published abstracts. For database searches, the following main keywords were the following text words: “adenomyosis” or “uterine endometriosis” [Mesh] AND “AMH” or “anti-mullerian hormone”.

Results

From the literature search, 8 abstracts of studies were retrieved and independently screened for inclusion by three authors. It was found that the most common therapeutic strategies (such as adenomyomectomy and high-intensity focused ultrasound (HIFU) do not alter AMH levels. Moreover, a higher expression of the AMH receptor II was observed in adenomyotic tissue, hence a possible therapeutic use of AMH was hypothesized.

Conclusion

The available evidence shows an unclear relationship between adenomyosis and AMH. Probably, women with adenomyosis have lower levels of AMH and the surgical treatment (adenomyomectomy, HIFU) does not alter this characteristic, therefore in all of them, ovarian function is not influenced.
Risk factors of new vertebral compression fracture after percutaneous vertebroplasty or percutaneous kyphoplasty
Authors: Cheng Yuanpei , Cheng Xiaokang , Wu Han
Published: August 2022

Background

New vertebral compression fracture (VCF) may occur in patients who underwent percutaneous vertebroplasty (PVP) or percutaneous kyphoplasty (PKP) for osteoporotic vertebral compression fracture (OVCF). However, the risk factors of new VCF remain controversial. The research aimed to analyze the risk factors of new VCF after PVP or PKP.

Methods

From August 2019 to March 2021, we retrospectively analyzed the patients who underwent PVP or PKP for OVCF at our institution. Age, gender, body mass index (BMI), smoking, drinking, hypertension, diabetes, fracture location, surgical method, Hounsfield unit (HU) value, preoperative degree of anterior vertebral compression (DAVC), bisphosphonates, bone cement volume, bone cement leakage, and cement distribution were collected. The risk factors were obtained by univariate and multivariate analysis of the data.

Results

A total of 247 patients were included in the study. There were 23 patients (9.3%) with new VCF after PVP or PKP. Univariate analysis showed that age (p < 0.001), BMI (p = 0.002), fracture location (p = 0.030), and a low HU value (p < 0.001) were significantly associated with new VCF after PVP or PKP. A low HU value was an independent risk factor for new VCF after PVP or PKP obtained by multivariate regression analysis (OR = 0.963; 95% CI, 0.943–0.984, p = 0.001).

Conclusions

In this study, a low HU value was an independent risk factor of new VCF after PVP or PKP.
Bacterial isolates from diabetic foot ulcers and their antimicrobial resistance profile from selected hospitals in Addis Ababa, Ethiopia
Authors: Atlaw Asegdew , Kebede Habtamu Biazin , Abdela Abdurezak Ahmed , Woldeamanuel Yimtubezinash
Published: August 2022

Introduction

Infected diabetic foot ulcer (IDFU) is a worldwide problem associated with diabetes mellitus. It could lead from soft tissue infection to bone infection and is a leading cause of lower limb amputation. Gram-negative and Gram-positive bacteria, including anaerobic bacteria and fungi, are considered potential causes of infection. The early diagnosis of DFU infection and appropriate treatment based on the identification of the pathogens and their antimicrobial susceptibility pattern is important for good prognosis. Therefore, the purpose of this study was to isolate the bacteria that infect foot ulcers in selected Hospitals and determine their antimicrobial resistance profile.

Method

An institutional-based multicenter, cross-sectional study was conducted in selected Hospitals in Addis Ababa, Ethiopia, from November 2020 to May 2021. A sterile swab was used to collect samples from the foot ulcer and a sterile needle to collect pus. Isolates were identified by culture, Gram-staining, and a series of biochemical tests. For each bacterial species identified, the antibiotic profiling was determined by the Kirby-Bauer disk diffusion method.

Results

one hundred and twenty-seven pathogenic bacteria were isolated from samples taken from 130 patients with a diabetic foot ulcer. Sixty-eight percent had growth of multiple microorganisms. Two-thirds (66.7%) of the isolates were gram-negative bacteria. The predominant bacterial species were S. aureus 25.19% (32/127), Pseudomonas species 18.89% (24/127), and Escherichia coli 16.53% (21/127). Overall, 92.9% (118/127) of the isolates were identified as multi-drug resistant. Gram-positive isolates were susceptible to chloramphenicol, clindamycin, and amikacin. Gram-negative isolates were also sensitive to chloramphenicol, aztreonam, and amikacin.

Conclusion

The majority of bacteria isolated from patients presenting with Diabetic foot ulcer infections were found to be multi-drug resistant in the study sites of the current study. The results demonstrate the importance of timely identification of infection of diabetic foot ulcers, proper sample collection for identification of the pathogens and for determining their antibiotic susceptibility pattern before initiating antimicrobial treatment
Energy risk measurement and hedging analysis by nonparametric conditional value at risk model
Authors: Li Ling , Hu Guopeng
Published: August 2022

The accurate measurement and management of energy risk have become important issues of the economic development and energy security for all countries. The existing literature generally adopts the Value at Risk (VaR). However, VaR does not satisfy the subadditivity axiom to measure the energy risk, which makes the calculation defective. In this paper, we use the Conditional VaR (CVaR) with the characteristics of coherent and convex risk measurement to measure energy risk under nonparametric kernel (NPK) framework. We consider how to use the energy derivatives to hedge the price risk of energy so that the result is more reasonable and effective. The empirical results show that the NPK method that we propose is more effective to measure the actual energy risk and carry out more effective risk hedging.
Distributed robust optimization scheduling of a steel plant integrated energy system considering the uncertainty of byproduct coal gas
Authors: Li Fan , Li Yuxiao , Niu Tao , Fang Sidun , Wu Wenguo
Published: August 2022

The steel plant integrated energy system (SPIES) is an important form in the steel industry. Improving the utilization efficiency of steam, electricity, coal gas and other energy flows is of great significance for both economic and environmental benefits. In this paper, a SPIES scheduling model is established according to the operation characteristics of coal gas holders, boilers and other equipment in steel plants. Meanwhile, to cope with the uncertainty of byproduct coal gas, this paper adopts an imprecise Dirichlet model (IDM) to construct a fuzzy set containing multisource coal gas production information. Then, according to duality theory and the big-M method, the original distributed robust optimization (DRO) model is transformed into a traditional mixed integer linear programming (MILP) model, which is solved by the column-and-constraint generation (CC&G) algorithm. Finally, a real steel production system is given in a case study. Case study illustrate that compared with the traditional robust method, the method proposed in this paper for a SPIES can effectively reduce the conservatism of the scheduling decision. Numerical simulation show that the proposed method can reduce total cost by 55,307.1¥, accounting for 1.91% of the total cost compared with robust optimization method and save 1,326.94 s of computational time compared with the stochastic optimization method, thus reaching balance between conservatism and computational efficiency.
Synthesis and applications of graphene and graphene-based nanocomposites: Conventional to artificial intelligence approaches
Authors: Tariq Waheed , Ali Faizan , Arslan Chaudhry , Nasir Abdul , Gillani Syed Hamza , Rehman Abdul
Published: August 2022

Recent advances in graphene research have enabled the utilization of its nanocomposites for numerous energy-based and environmental applications. Recently, the advancement in graphene-based polymer nanocomposites has received much attention with special emphasis on synthesis and application. Graphene-based nanocomposites show astonishing electrical, mechanical, chemical, and thermal characteristics. Graphene nanocomposites (GNCs) are synthesized using a variety of methods, including covalent and non-covalent methods, a chemical-based deposition approach, hydrothermal growth, electrophoresis deposition, and physical deposition. Chemical methods are the most viable route for producing graphene in small quantities at low temperatures. The technique can also produce graphene films on a variety of substrate materials. The use of artificial intelligence (AI) for the synthesis of AI-created nanoparticles has recently received a lot of attention. These nanocomposite materials have excellent applications in the environmental, energy, and agricultural sectors. Due to high carrier mobility, graphene-based materials enhance the photocatalytic performance of semiconductor materials. Similarly, these materials have high potential for pollutant removal, especially heavy metals, due to their high surface area. This article highlights the synthesis of graphene-based nanocomposites with special reference to harnessing the power of modern AI tools to better understand GNC material properties and the way this knowledge can be used for its better applications in the development of a sustainable future.
Can green technology innovation alleviate the regional energy dilemma? Evidence from 30 provinces in China
Authors: Xu Yongji , Li Jian , Zhong Shen
Published: August 2022

High energy intensity and energy consumption structure are the main contradictions restricting China’s green economic growth. Green technology innovation is an important factor to alleviate the energy dilemma. Referring to the IPC Green Inventory launched by the World Intellectual Property Organization, the green patents of 30 provinces in China from 2004 to 2019 are screened. Based on the panel data of 30 provinces in China, this study empirically tests the impact of green technology innovation on energy intensity and energy structure by employing fixed effect model and quantile regression model. The empirical results show that green technology innovation can significantly reduce energy intensity and energy structure, and the long-term effect is obviously higher than the short-term effect. Compared with the green utility model patent representing general innovation, the green invention patent representing disruptive innovation expresses more momentous long-term and short-term effect. The sustainable effect of green technology innovation will gradually weaken with the reduction of energy intensity and energy structure. For provinces with low energy structure, the impact of green technology innovation is no longer significant. Instrumental variable method and robustness test prove that the conclusion of this study is robust. This study provides support for the government and enterprises to promote technological innovation and play a part in alleviating the energy dilemma.
Environmental protection tax, corporate ESG performance, and green technological innovation
Authors: Li Jing , Li Shiyu
Published: August 2022

Environmental, social, and corporate governance (ESG) performance is an analytical framework for measuring the contribution of enterprises to sustainable development and fulfillment of social responsibility. The introduction of an environmental protection tax in China in 2018, which imposes tax on the pollution emission of enterprises, helps enterprises improve their ESG performance and raise their environmental awareness, thus effectively promoting their green technological innovation to achieve sustainable development. This study examines the effect of China’s environmental protection tax on corporate ESG performance and green technology innovation. The findings showed that the environmental protection tax in China can vastly improve the ESG performance and green technological innovation, with the ESG performance exhibiting a partial mediating effect in promoting corporate green technological innovation. The mediating effect in enhancing ESG performance and green technological innovation varies with the nature of firms’ property rights and regions.
Determination of a prediction model for therapeutic response and prognosis based on chemokine signaling-related genes in stage I–III lung squamous cell carcinoma
Authors: Lai Jinzhi , Yang Shiyu , Chu Shuqiang , Xu Tianwen , Huang Jingshan
Published: August 2022

Background: The chemokine signaling pathway plays an essential role in the development, progression, and immune surveillance of lung squamous cell carcinoma (LUSC). Our study aimed to systematically analyze chemokine signaling-related genes (CSRGs) in LUSC patients with stage I–III disease and develop a prediction model to predict the prognosis and therapeutic response.

Methods: A total of 610 LUSC patients with stage I–III disease from three independent cohorts were included in our study. Least absolute shrinkage and selection operator (LASSO) and stepwise multivariate Cox regression analyses were used to develop a CSRG-related signature. GSVA and GSEA were performed to identify potential biological pathways. The ESTIMATE algorithm, ssGSEA method, and CIBERSORT analyses were applied to explore the correlation between the CSRG signature and the tumor immune microenvironment. The TCIA database and pRRophetic algorithm were utilized to predict responses to immunochemotherapy and targeted therapy.

Results: A signature based on three CSRGs (CCL15, CXCL7, and VAV2) was developed in the TCGA training set and validated in the TCGA testing set and GEO external validation sets. A Kaplan–Meier survival analysis revealed that patients in the high-risk group had significantly shorter survival than those in the low-risk group. A nomogram combined with clinical parameters was established for clinical OS prediction. The calibration and DCA curves confirmed that the prognostic nomogram had good discrimination and accuracy. An immune cell landscape analysis demonstrated that immune score and immune-related functions were abundant in the high-risk group. Interestingly, the proportion of CD8 T-cells was higher in the low-risk group than in the high-risk group. Immunotherapy response prediction indicated that patients in the high-risk group had a better response to CTLA-4 inhibitors. We also found that patients in the low-risk group were more sensitive to first-line chemotherapeutic treatment and EGFR tyrosine kinase inhibitors. In addition, the expression of genes in the CSRG signature was validated by qRT‒PCR in clinical tumor specimens.

Conclusion: In the present study, we developed a CSRG-related signature that could predict the prognosis and sensitivity to immunochemotherapy and targeted therapy in LUSC patients with stage I–III disease. Our study provides an insight into the multifaceted role of the chemokine signaling pathway in LUSC and may help clinicians implement optimal individualized treatment for patients.
Cuproptosis scoring model predicts overall survival and assists in immunotherapeutic decision making in pancreatic carcinoma
Authors: Liu Tijun , Liu Qing , Wang Yongju , Yang Rong , Tian Fang
Published: August 2022

Background: Cuproptosis is a newly identified form of non-apoptotic cell death that is associated with the progression and treatment responses in pancreatic adenocarcinoma (PAAD). However, its impact on oncology and tumor microenvironment (TME) remains unclear.

Methods: Hub genes were identified using least absolute shrinkage and selection operator (LASSO) Cox regression for 25 newly reported cuproptosis-related regulators and subjected to stepwise regression to obtain cuproptosis-related score (CuRS). Additionally, the clinical significance, functional status, role on TME, and genomic variation of CuRS were further examined systematically.

Results: A CuRS model incorporating TRAF2, TRADD, USP21, FAS, MLKL, TNFRSF10B, MAPK8, TRAF5, and RIPK3 was developed. The stability and accuracy of this risk model as an independent prognostic factor for PAAD were confirmed in the training and external validation cohorts. Patients in the high-CuRS group had “cold” tumors with active tumor proliferation and immunosuppression, whereas those in the low-CuRS group comprised “hot” tumors with active immune function and cell killing capacity. Additionally, patients in the high-CuRS group carried fewer genomic copy number variations (CNVs) and greater somatic mutations. Furthermore, patients in the low- and high-CuRS groups exhibited increased sensitivity to immunotherapy and chemotherapy, respectively.

Conclusion: We developed and validated a robust CuRS model based on cuproptosis to assess patients’ prognoses and guide clinical decision-making. Overall, the findings of this study are expected to contribute to the comprehensive understanding of cuproptosis and facilitate precise treatment of PAAD.