bluuebunny/crossref_metadata_2025 huggingface dataset:
Ribonucleases and Immunoribonucleases as Potential Modalities of Anticancer Therapy
Authors: Smolewski Piotr , Kowalik Monika , Witkowska Magdalena , Smolewski Piotr
Published: September 2020

A novel approach of antitumor treatment, that involves targeting RNA either using specific antisense
oligonucleotides or cytostatic/cytotoxic ribonucleases (RNases), is being promoted. Among recently
described cytotoxic RNases, amphibian RNases, including ranpirnase (onconase; ONC) and Amphinase (rAmph), are promising anticancer agents. They manifest strong antitumor effects and act synergistically with
several cytostatics. Recently, rapidly developed proteins by engineering of RNases, displayed cytotoxic
activity against several types of malignant cells. Most recent data show the role of microRNAs in mediating
tumor progression, opening a new field of possible molecular targets for RNases. This review summarizes
the current status of those RNases and immunoRNases as promising novel anticancer therapeutics.
Transplantation of Induced Neural Stem Cells Derived from Human Fibroblasts Promotes Functional Recovery of Spinal Cord Injury in Rats
Authors: Kiani Sahar , Mohammadshirazi Atiyeh , Kashkouli Maedeh , Shahbazi Ebrahim , Asghari Hassan , Kheymeh Abolfazl , Ghodsi Zahra , R Vaccaro Alexander , Rahimi-Movaghar Vafa , Kiani Sahar
Published: September 2020

Background: Traumatic injury to the spinal cord causes cell death, demyelination, axonal degeneration,
and cavitation, resulting in functional motor and sensory loss. Stem cell therapy as a promising approach
for spinal cord injury (SCI) has some challenges, such as immunological responses to grafted cells.
Transplantation of autologous trans-differentiated cells can be a useful strategy to overcome this problem.
Materials and Methods: In this research, we transplanted human-induced neural stem cells (hiNSCs),
which were trans-differentiated from adult human fibroblasts into the injured spinal cord of adult rats on
day seven post-injury. Before transplantation, hiNSCs were explored for expressing NSCs general protein
and genes and also, their normal karyotype was examined. After hiNSCs transplantation, behavioural tests
(BBB score and grid walk tests) were performed weekly and finally histological assessment was done for
exploring the cell fates and migration.
Results: Our results showed the cell viability, differentiation, and migration of transplanted hiNSCs was
significantly improved in the injured site of the spinal cord up to seven weeks after the SCI. Also, the
behavioural analysis revealed the enhanced locomotor functions of the animals that underwent
transplantation after seven weeks. Our data provide strong evidence in support of the feasibility of hiNSCs
for cell-based therapy in SCI rats.
Who Governs in Deep Crises?
Authors: Merkel Wolfgang
Published: September 2020

The Berlin Republic of today is neither Weimar (1918–1932) nor Bonn (1949–1990). It is by all standards the best democracy ever on German soil. Nevertheless, during the COVID-19 crisis there was a shift from democracy as a mode of governance to what the controversial legal theorist Carl Schmitt (1922) affirmingly described as a “state of exception”; a state that is desired and approved by the people (through opinion polls). It was the hour of the executive. The parliament disempowered itself. There was very little, if any, contestation or deliberation during the first eight weeks of the COVID-19 crisis. This article reflects on the implications of this mode of governance on institutions and actors of democracy in Germany, and offers a way of assessing the wellbeing of democracies in times of deep crisis.
How Will the COVID-19 Pandemic Affect Democracy?
Authors: Rapeli Lauri , Saikkonen Inga
Published: September 2020

In this commentary, we discuss some possible effects of the COVID-19 pandemic in both established and newer democracies. We expect that the pandemic will not have grave long-term effects on established democracies. We assess the future of democracy after COVID-19 in terms of immediate effects on current democratic leaders, and speculate on the long-term effects on support for democratic institutions and principles. We also discuss possible implications of the COVID-19 pandemic on the global trends in democratic backsliding. We predict that, in the short term, the repercussions of the pandemic can aggravate the situation in countries that are already experiencing democratic erosion. However, the long term economic effects of the pandemic may be more detrimental to non-democratic governance.
Open Borders and the COVID-19 Pandemic
Authors: Owen David
Published: September 2020

This paper considers the implications of COVID for open borders. It notes that while COVID concerns do not directly challenge arguments for open borders, the pandemic has revealed two more general phenomena that are salient for such arguments. The first concerns the increasing unmooring of legal borders from physical spaces and the interaction of surveillance and identification technologies with this process. The second addresses the issue of interdependency and the potentially negative implications of open borders if not underpinned by a global basic structure.
No Demos in the Pandemic
Authors: Abbas Asma
Published: September 2020

That the present moment ties multiple crises together—not least because each is a future of pasts that wound(ed) through each other—must be factored into our intercessions and visions. If every crisis is also a call to order, then what order, old or new, does the pandemic call us to? Its literality provokes us to keep both the pan and the demos in sight, just as they are being extinguished through borders, disease, poverty, insecurity, hatred, and disposability in the global postcolony. We are asked to remember that capital and colony are inseparable, that the nation-state is too suspicious a source of comfort, that the eroding claims of citizenship across the postcolonial and post-democratic fascist failed states are instructive and prophetic, and that the assumptions of place and movement in our frames of the democratic political need revisiting.
The Effectiveness of the Supervision of the Prosecutor's Commission in Indonesia
Authors: Iswantoro Iswantoro , Saputra Rian , Doyoharjo Anggo , Luthviati Resti Dian
Published: September 2020

This study aims to analyze the causes of the ineffective supervision carried out by the Prosecutor's Commission in an effort to improve the performance of the Public Prosecutors Office of the Republic of Indonesia. The facts show that there are many negative public reports and complaints regarding the performance of the AGO. These reports are examined first, before being given a recommendation to the Attorney General. As the external supervisor of the Public Prosecution Service, the Prosecutor's Commission has the task of supervising, monitoring and evaluating the behavior of prosecutors and public prosecutors. The existence of the Republican Prosecutor's Commission is experiencing weaknesses in carrying out its duties and authorities.

Keywords:

Prosecutor's Commissioner; Effectiveness; Indonesia.
A Study on the Guidance Needs of Pupils Institutions from both Literate and Illiterate parents’ background & Management
Authors: HOQUE MD ASRAUL
Published: September 2020

The present study aims to explore the nature of Guidance Needs of Pupils for 11th Grade Institutions from both Literate and Illiterate parents’ background & Management for Pupils of 8th Grade Institutions: An Analytical Study of Murshidabad District, West Bengal, India. The populations consist of Pupils for 11th Grade Institutions from both Literate and Illiterate parents’ background & Management for Pupils of 8th Grade Institutions Murshidabad district. Questionnaire on guidance need was distributed. Sampling Random technique was applied to collect the data among the 400 for Pupils for 11th Grade Institutions from both Literate and Illiterate parents’ background & 186 for Management for Pupils of 8th Grade Institutions Govt.Aided School and Private Schools. The study identifies the phenomena related to various guidance needs the pupils coming from both literate and illiterate Parents’ background & Govt.Aided School pupils and Private Schools pupils. The complex and varied nature of the world of service pose a huge challenge to the youngest pupils today. Many pupils with higher secondary/secondary schools/Madrasahs knowledge face difficulties in making decisions due to lack of sufficient guidance, which hampers their progression. The Results and finding shows there is a significant difference in mean score on the (physical, social, psychological, educational and vocational) guidance needs among 11th grade pupils with respect to their parents as literate and illiterate. There is a significant difference in Guidance needs (physical, social, psychological, educational and vocational) among 8th Grade institutions pupils with respect to their management.
University Structural Units Rankings: Models and Solutions
Authors: Konstantinova L. V.
Published: September 2020

Formation of strategic management tools in Russian universities, including mechanisms for ranking the activities of structural units is an important task of the innovative development of universities.

The article discusses the rating models of structural units operating in Russian universities. Based on the analysis of real practices, the university-wide models for ranking educational and scientific units are distinguished. A complex-structured rating model of all structural divisions of the university is characterized by the example of one of the leading universities. The article highlights the general characteristics of ranking models used by domestic universities. To a large extent, they concentrate around the methods of assessing the activities of organizational units that have developed in the strategic management system. They consider the achievement of indicators of the Universities Effectiveness Monitoring as the target goals to increase their competitiveness.
Flagship Universities as Development Potential of Regions and Industries
Authors: Berestov A. V. , Guseva A. I. , Kalashnik V. M. , Kaminsky V. I. , Kireev S. V. , Sadchikov S. M.
Published: September 2020

This article presents the research results of flagship universities activities, which support social and economic development of the Russian Federation regions, including the creation of innovation, technological and social region development centers. The research covers the period from 2015 to 2018. The following core areas of flagship universities were analyzed: educational, research, integration with regions and high-tech industries, international activities. Essential aspects of financial and economic activity and employment policy were considered. The analysis was based on 41 quantitative and 11 qualitative indicators, among which 8 indicators were prioritized. In the analysis the following data sources were used: statistical forms 1-Monitoring, rankings agencies data, etc. The effectiveness of flagship universities was studied. Problems and positive tendencies in flagship universities development were determined and analyzed.
Pendekatan Lansekap Budaya dalam Pengelolaan Ekomuseum: Studi di Kabupaten Minahasa, Sulawesi Utara
Authors: Wuisang Cynthia E. V. , Rengkung Joseph , Rondonuwu Dwight M.
Published: September 2020

Lansekap budaya adalah fenomena integrasi dari lahan (land), manusia, budaya, dalam kurun waktu dan sejarah yang panjang. Dalam upaya pelestarian Lansekap Budaya berkelanjutan, Ekomuseum adalah salah satu model pengelolaan dengan berbasis sosio-budaya dan etnoekologi. Konsep Ekomuseum berkembang dengan pesat di berbagai negara di belahan dunia dengan berbagai strategi yang melibatkan masyarakat dalam perencanaan dan pengelolaan. Tulisan ini memetakan interaksi masyarakat Minahasa dengan lingkungannya dan bagaimana ekomuseum digunakan sebagai salah satu pendekatan dalam pengembangan dan pelestarian lansekap budaya. Metoda yang digunakan adalah deskriptif-kualitatif dengan melakukan survey terhadap sejumlah permukiman wilayah regional dan melihat potensi ekomuseum masing-masing teritory. Data kemudian dianalisis berdasarkan pendekatan geografi. Kesimpulan tulisan ini adalah merekomendasikan model pengelolaan ekomuseum yang ideal untuk Kabupaten Minahasa.
Otentisitas Kawasan dan Nilai Ekonomi sebagai Penjaga Identitas Kawasan Pelestarian Kebayoran Baru Jakarta
Authors: Prabowo A. Hadi , Hartanti Nurhikmah B.
Published: September 2020

Keaslian atau otentisitas kawasan merupakan prinsip pelestarian dengan pendekatan berbasis nilai (value-based approach). Otentisitas kawasan pada kawasan pelestarian akan memperkuat nilai arti penting (significance). Dengan dapat memperhatikan otentisitas pada kawasan yang mempunyai keunikan sehingga dapat menjadi identitas kawasan. Kawasan yang mempunyai otentisitas tinggi cenderung akan memberikan nilai ekonomi yang tinggi. Nilai ekonomi terdiri dari use value dan non use value. Use value berdasarkan harga tanah sedangkan non use value dipengaruhi oleh rasa gengsi, meningkatkan status sosial dan kebanggaan. Kawasan yang mempunyai otentisitas tinggi akan mempunyai identitas yang lebih kuat dan berpengaruh terhadap use value atau harga tanah. Kebayoran Baru merupakan kawasan pelestarian yang telah mengalami perubahan dan masih terdapat elemen kawasan yang memiliki otentisitas. Makalah ini membahas keterkaitan antara otentisitas dengan nilai ekonomi. Metode yang digunakan adalah superimpose peta otentisitas struktur jalan, bentuk ruang terbuka hijau, bentuk bangunan dengan peta harga tanah. Terdapat kecenderungan keterkaitan antara otentisitas  dengan nilai ekonomi.
Karakter Arsitektural Bangunan Kolonial sebagai Warisan Budaya Kota Singaraja
Authors: Agusintadewi Ni Ketut , Prajnawrdhi Tri Anggraini , Satria Made Wina
Published: September 2020

Menelusuri sejarah Kota Singaraja sebagai ibukota Kabupaten Buleleng di Bali Utara selalu bertalian erat dengan peninggalan arsitektur kolonial Belanda. Peninggalan arsitektur kolonial masih dapat ditemui dibeberapa sisi kota, tetapi tidak sedikit yang sudah mengalami perubahan bentuk, bahkan tampak berbeda dengan keadaan semula. Adanya akulturasi dalam arsitektur antara penjajah dan kultur Bali dan juga penyesuaian pada iklim tropis menyebabkan arsitektur kolonial di kota ini memiliki tampilan yang unik. Tujuan penelitian ini adalah menelusuri pembentuk elemen fasade bangunan dan pembentuk elemen ruang dalam sebagai karakter arsitektural bangunan kolonial di Kota Singaraja. Metode penelitian yang digunakan adalah metode kualitatif dengan teknik pengambilan data secara observasi, wawancara, dan dokumentasi. Bangunan kolonial yang dipilih sebagai kasus studi dilakukan dengan teknik purposive sampling melalui beberapa kriteria. Analisis data dilakukan secara induktif dengan lebih menekankan kepada makna dan nilai sejarah. Hasil pengamatan peneliti menjadi salah satu cara untuk memaparkan dan menyimpulkan kedua elemen pembentuk karakter arsitektural pada bangunan-bangunan kolonial tersebut. Hasil penelitian menunjukkan bahwa bangunan kolonial di Kota Singaraja memiliki karakter arsitektural yang dapat ditentukan dari jendela, pintu masuk, atap, dan dinding. Sementara karakter yang lain dapat ditentukan dari denah dasar dan bentuk bangunan. Indikator dari variabel-variabel tersebut semakin memperkuat karakter arsitektural pada bangunan-bangunan kolonial tersebut secara fisik dan visual sebagai warisan budaya kota dalam memperkuat identitas Kota Singaraja sebagai kota pusaka.
Fleksibilitas Hunian Nelayan Berpanggung Terapung di Danau Tempe Kabupaten Soppeng
Authors: Beddu Syarif , Yudono Ananto , Harisah Afifah , Sir Mochsen
Published: September 2020

Danau Tempe merupakan danau tertua dan terluas di jazirah Provinsi Sulawesi Selatan, menggenangi tiga kabupaten kota yaitu, Kabupaten Wajo, Soppeng, dan Sidrap. Keberadaan Danau Tempe memberi pengaruh terhadap pola mata pencaharian dan pola bermukim bagi masyarakat sekitarnya. Mereka hidup bertani (pallaon ruma) dan nelayan (pakkaja), menempati kawasan permukiman di Kampung Salo Mate, Kelurahan Limpomajang Kecamatan Marioriawa Kabupaten Soppeng.  Sebagian masyarakat nelayan ini hidup bermukim di atas permukaan air Danau Tempe, dan menempati “rumah berpanggung terapung” (RBT).  Rumahnya bentuk panggung dan  berdiri di atas rakit (rai), dihuni sekitar tahun 2000-an. Bermukim secara terapung di Danau Tempe menimbulkan fleksibilitas ruang gerak secara makro dan mikro yang mengisyaratkan suasana kemaritiman. Persoalan rumah terapung adalah, bergerak kesana-kemari, bebas orientasi, berubah-ubah kapling, berpindah dengan bantuan tenaga perahu bermotor, rakit berfungsi pelampung berbahan bambu sewaktu-waktu akan diganti. Tujuan keberadaan hunian RBT bagi masyarakat nelayan adalah untuk memudahkan, mencari ikan sampai ke tengah Danau Tempe.
Transformasi Bentuk dan Material Rumah di Permukiman Pesisir Suku Bajoe di Bone
Authors: Nadjmi Nurul , Talaohu Inya Masita
Published: September 2020

Kebudayaan bermukim dengan lingkungan masyarakat yang berbudayamemberikan nuansa masa lampau yang terbentuk dalam sebuah wujud budaya dan telah diwariskan secara turun-temurun. Dalam perjalanannya budaya tersebut mengalami perubahan dalam proses akulturasi dalam bermukim dari satu individu ke individu yang lain dan juga dari satu generasi ke generasi yang lain. Hal ini di alami oleh Suku Bajoe di Bone. Kebudayaan menjadi bagian yang sangat berpengaruh terhadap bentuk dan material rumah yang ada. Yang mana terdapat nilai-nilai filosofi tersendiri terhadap bentuk dan material rumah serta merupakan faktor yang mentransformasi bentuk rumah pada permukiman Suku Bajoe di Bone. Tujuan dari penelitian ini adalah untuk mengetahui sejauh mana transfomasi terhadap bentuk dan material pada rumah dipermukiman pesisir Suku Bajoe yang berada di tiga tempat yang berbeda. Metode penelitian yang digunakan dalam penelitian ini adalah penelitian deskriptif kualitatif. Sehingga didapatkan bentuk transformasi yang terjadi pada bentuk dan material rumah pada permukiman Suku Bajoe.
Arsitektur Masjid Sunan Gunung Jati Cirebon sebagai Akulturasi Budaya Islam, Jawa, dan Cina
Authors: Siswoyo Suhandy , Nuryanto  , Mardiana Riskha
Published: September 2020

Masjid berfungsi tidak hanya sebagai tempat ibadah dan syiar, tetapi juga menjadi tempat untuk mengatur siasat perang melawan penjajah. Peranan Wali Sanga dalam proses menyebarkan agama Islam, ternyata memiliki hubungan yang sangat erat dengan arsitektur masjidnya. Tujuan penelitian ini adalah untuk menemukan karakteristik bentuk arsitektur Masjid Sunan Gunung Jati Cirebon yang dipengaruhi oleh budaya Jawa berakulturasi dengan Cina. Lokasi yang diteliti fokus pada Masjid Sunan Gunung Jati di Kabupaten Cirebon Provinsi Jawa Barat. Kawasan masjid yang diteliti meliputi: Langgar Agung Karaton Kasepuhan, Masjid Dok Jumeneng, dan Masjid Pajlagrahan. Metode yang digunakan dalam penelitian ini yaitu deskripstif kualitatif dengan cara mengobservasi dan mendeskripsikan kembali kondisi Masjid Sunan Gunung Jati dan kawasannya. Hasil penelitian menunjukkan adanya karakteristik arsitektur yang khas pada Masjid Sunan Gunung Jati, yaitu: (a) Bentuk denah dan tampak yang simetris; (b) Tata ruang luar atau lansekap yang khas Sunda, Jawa berpadu dengan Cina; (c) Material masjid yang semuanya berasal dari alam; (d) Ornamen atau ragam hias masjid sebagai akulturasi Budaya Hindu, Islam, Jawa, dan Cina; (e) Site plan masjid; (f) Struktur dan konstruksi, termasuk akulturasi Islam, Jawa, dengan Cina.
What are the functions of nails?
Authors: Padda Inderbir
Published: September 2020

What are the functions of nails?

The nails embryonic origin starts composing at t​he seventh to eighth weeks during development and is entirely constructed at childbirth. The human anatomy of the nail comprises epithelial and connective tissue components; nail matrix, nail bed, nail plate, nail folds, mantle, hyponychium, and isthmus. The nail functions to provide sensory, thermoregulatory, and protective features to the distal fingers and toes. The average nail lengthens two-three millimeters every four weeks, replacing itself entirely once every six-nine months, depending on the individual.​ The nail growth, color, consistency, and appearance may provide insight into an individual's health and manifestations of localized or deeper systemic conditions
Las clases sociales en la expansión del bachillerato general en España
Authors: López García Julián
Published: September 2020

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Nepalese Teachers' Resilience: Adjusting Learning Context in Pandemic
Authors: Adhikari Devi Prasad
Published: September 2020

Schools and colleges have been closed due to pandemic. Face to face teaching and learning has been suspended. This essay explores the changing teaching and learning context and teacher resilience in Nepal during last three months.
Year of the Bull?
Authors: Hollis Leah
Published: September 2020

The Covid-19 global has exposed another pandemic, that of racism. As a result, Chinese citizens throughout the global community have faced bullying and malice. Bullying is a global problem; in this case the international community has concentrated its collective anxiety about Covid-19, which originated in Wuhan, China, to discriminate against those of Chinese descent. Therefore, this short essay reflects on some historical and psychological underpinning which inform the cruelty and blame ascribed to many Chinese people during this unprecedented public health emergency.
Challenges of Online Education during COVID-19 Pandemic in Nepal
Authors: Khati Kabita , Bhatta Khem
Published: September 2020

Covid-19 urged colleges and universities to shut down. The online education that nourished after COVID-19, has been challenging in Nepal because students, teachers, and administrators were not prepared for it. Stakeholders of education should work in many areas to enhance the effectiveness of online education and make it complementary to classroom education.
College Affordability and U.S. News & World Report Rankings:
Authors: Taylor Z , Alsmadi Izzat
Published: September 2020

In an era of billions of dollars in outstanding student loan debt, researchers have posited that the U.S. News & World Report rankings continue to be an influential source of information for prospective students, yet these rankings do not include college affordability metrics in their ranking algorithm. As a result, this study performed a series of college affordability experiments by integrating affordability metrics into the U.S. News ranking algorithm to explore whether any affordability metric predicts overall ranking. Results suggest better ranked institutions enrolled lower percentages of Pell grant receiving students (p < 0.00), while the percentage of undergraduates receiving state aid predicted better rankings only at Regional Midwest and Regional West Universities (p < 0.05). These results suggest many college affordability metrics are not predictive of ranking among the best-ranked, elite institutions. Implications for theory, practice, and college student choice are addressed.
Toward “Living Together”: Developing Intercultural Sensitivity Through Arabic Foreign Language Coursework
Authors: Karkour Islam
Published: September 2020

This paper investigates intercultural sensitivity as an expected outcome of an Arabic as a foreign language class in higher education. The study used pretest and posttest design to measure the change in 26 students’ intercultural sensitivity after a semester of language study. The participants studied elementary level Arabic as a foreign language at an American university in the northeast United States. The Intercultural Development Inventory (IDI) was used to measure intercultural sensitivity. No significant difference was found in the Arabic students’ levels of intercultural sensitivity as measured by the IDI, on average. The students’ Arabic instructor was interviewed, and the elementary level Arabic textbook was critically reviewed to understand how students’ intercultural sensitivity might be improved; a primary recommendation is to provide instructors with training on incorporating culture into foreign language curriculum.
Going to University: The Influence of Higher Education on the Lives of Young South Africans
Authors: Adenuga Kehinde
Published: September 2020

Going to University: The Influence of Higher Education on the Lives of Young South Africans is a great book written very well by the authors. The use of the narratives gives the book an engaging and readable quality that will make a reader to complete the reading. The authors narrated the interviews conducted with 73 young people six years after they enrolled at one of the urban schools in South Africa. As the book progresses, the authors further introduced us to 20 young people whose stories were narrated in detail.
Ambitious and Anxious:
Authors: Liu Shuning
Published: September 2020

Over the recent decade, the United States has witnessed a growing influx of self-funded Chinese international undergraduate students into its university campuses. Mainstream U.S. media accounts have tended to hold unexamined stereotypes about these international students. This essay review of Ambitious and Anxious: How Chinese College Students Succeed and Struggle in American Higher Educationhighlights the importance of exploring students’ agency in their pursuit of international education. The article points out that to better understand Chinese international undergraduate students’ ambition and anxiety, we must link their emotional and psychological burdens, their academic and social struggles, as well as their agency, to the changing national and international contexts where these students’ transnational mobility is situated. The essay also calls for the need for further research into the politics of international student mobilities.
An Intricate Balance: The Challenge of Caring During COVID-19 While Maintaining High Student Expectations
Authors: Gullo Gina
Published: September 2020

Understanding the challenges faced by graduate students during the COVID-19 pandemic is difficult for professors aiming to maintain high expectations of students. This essay explores the balance between caring for and challenging students in the face of their needs and limitations during social distancing.
Creative and Critical Thinking, and Ways to Achieve It
Authors: De Gastyne Michèle
Published: September 2020

This paper discusses creative and critical thinking across wide cultural and historical frameworks. It begins with an exploration of Socratic Dialectics in multiple contexts, highlighting the need for innovative views and investigative practices using Art and Culture. A major objective of this project is to use the Arts for finding the universal sources of culture through exploring diversity, with a particular focus on the role of Africa as the cradle of humanity and dynamic initiatives on the continent. Through collaborative advocacy and the interdisciplinary approach of Leonardo daVinci (1452-1519), relevant generalities for human rights education and humanitarian efforts, this paper contextualizes intercultural dialogue for universal equity in young people’s development. The paper also explores how education influences the political developments of learners. The paper then shows how humanistic and intercultural approaches to education are fostering creative and critical thinkers worldwide.
The Okule Cult Education and Practice in Ghana
Authors: Ntewusu Samuel , Awubomu Richard , Ntewusu Diana Amoni , Adasi Grace
Published: September 2020

Using oral interviews, archival sources, observation, and published materials, we discuss the recruitment and training processes of the Okule Cult, an all-female cult. We analyze information obtained from the Nawuris of Northern Ghana to give insights into the relevance of Okule education practices to communities in Ghana. Knowledge about how members of the Okule cult educate new inductees and younger members advances our understanding of the continued importance of African Traditional Education. It would aid efforts to decolonize education on the African continent. The findings of our study can help educational authorities provide a balanced and holistic educational experience to learners.
Forecasting of COVID-19 Cases in Kurdistan Region Using Some Statistical Models
Authors: Hassan Hussen Shekhmous
Published: September 2020

Nowadays the new universal disease of the coronavirus that is called the epidemic COVID-19 is spread as geometric progression among the people around the world, so, such pathogen considered the most dangerous threat facing humanity. This study aimed to derive the best forecasting models for the close future cases of infected, recovered, and deaths in the four provinces of Kurdistan Region-Iraq to avoid more loss of human lives by applying more health care in certain province. Two forecasting methods were used including Exponential Smoothing and ARIMA models. The results indicate that both ARIMA and Exponential Smoothing models were close to each other for predicting the infected cases of COVID-19 in Kurdistan Region provinces, and the predicting models show that the pandemic might not be under control unless the people apply the government instructions for health care and keep social distances.
Photodynamic Therapy Using Endoscopy Capsule Robot
Authors: Hamdy ElGohary Sherif , Sabah Mohamed Yomna , Hany Elkhodary Mennatallah , Ahmed Omnya , Hesham Mennatallah
Published: September 2020

Among the photosensitizers used in Photodynamic therapy (PDT) technique for cancer treatment, it is found out that the Methylene blue and glycoconjugates chlorine are the best ones for this purpose. In this paper, it is suggested to use Active Capsule Wireless Endoscopy Robot instead of the traditional endoscope. The capsule has many valuable features. It uses LEDs as a source of light in the PDT to kill the colon cancer cells. So, the doctor can make use of the advantage of applying the LED light locally at the tumor which was previously injected by the photosensitizers, the light activates these photosensitizers and a photochemical reaction starts that makes the colon cancer cells die. The light with effective wavelength and power density, energy level and controlled LED light intensity will be applied. Active locomotion capsule endoscopy with an electromagnetic actuation system that can achieve a 3-D locomotion and guidance within the digestive system. The paper also discussed how to manage the required power in the capsule for all parts, LEDs, camera, transceiver, and locomotion.
On Establishing QoS for Composite Services
Authors: Son Nguyen Van , Hieu Vo Dinh
Published: September 2020

Service  composition  is  a  process  of combining existing atomic services to perform a complex task. To choose atomic services for a composite service, usually  both  functionality  and  quality  of  service  (QoS) are  considered.  The  QoS  of  the  composite  service obviously  depends  on  QoS  of  atomic  services.  In  this research,  we  propose  a  simple  approach  for  the composite  service  and  atomic  services  to  establishing suitable  QoS  values.  Experiment  shows  that  our approach  is  feasible  and  significantly  better  than  the exhaustive approach in performance aspect.
Apresentação
Authors: Maciel Alda Maria Coimbra Aguilar
Published: September 2020

Prezados/as leitores/as da CEB,apresentamos o primeiro número do quarto volume da Revista Cadernos de Educação Básica (CEB). Como nossas normas para autores têm passado por adequações, temos artigos com diferentes formatações, pois preferimos preservar as submissões originais.Nesse número, contamos com artigos de diversas áreas do conhecimento e dois relatos de experiência. Também acolhemos submissões para a Revista Física em Revista - Cadernos de Ensino do Colégio Pedro II.Esperamos que esses trabalhos propiciem reflexões que contribuam para o desenvolvimento criativo de nossos saberes e práticas pedagógicas.Boa leitura!Profª. Drª. Alda Maria Coimbra Aguilar MacielEditora-gerente da Revista Cadernos de Educação Básica
UM RELATO SOBRE UMA AULA DE CINEMÁTICA PARA ALUNOS DE ENSINO MÉDIO USANDO A METODOLOGIA DE APRENDIZAGEM ATIVA POE
Authors: Fagundes Ricardo , Sasaki Daniel
Published: September 2020

O ensino centrado na figura do professor tem se mostrado ineficaz no que tange não somente a aprendizagem de determinados conteúdos, mas também em abarcar as mais diversas habilidades educacionais do século XXI. Nesse sentido, uma turma de um colégio da rede federal de ensino, no Rio de Janeiro, teve uma sequência de aulas ativas de cinemática durante o primeiro trimestre de 2018. Esse trabalho é o relato de uma aula envolvendo movimento uniforme. A metodologia usada foi POE (previsão – observação – explicação), de essência construtivista, fundamentada em conflitos cognitivos. Primeiramente, na etapa previsão, o aluno expõe seu pensamento inicial em relação a um determinado assunto. Na segunda etapa, o aluno irá observar uma simulação computacional ou um experimento, por exemplo. Assim, o aluno percebe que o observado não era o previsto e, em cima disso, na terceira e última etapa, pode explicar o fenômeno abordado. Nessa aula, foi utilizado o software livre Tracker na etapa da observação. O objetivo desse relato é auxiliar professores que estão buscando redirecionar o foco de suas aulas para os alunos, fazendo o uso de metodologias ativas.
O ENSINO DA MATEMÁTICA: CONTEXTUALIZAÇÃO E PRÁTICA ATRAVÉS DO ESTUDO DO PARAFUSO SEXTAVADO
Authors: Abreu Carlos Eduardo de Paula , Ferreira Francinildo Nobre
Published: September 2020

Em diversas salas de aulas ou ambientes escolares, a forma como a Matemática vem sendo ensinada não permite que os alunos relacionem os conteúdos aprendidos com o seu cotidiano. Cabe ao professor mostrar a aplicabilidade da Matemática no dia a dia, sempre que for possível. A questão que se coloca é: como conscientizar os alunos sobre as aplicações dos conteúdos matemáticos no seu cotidiano e motivá-los ao estudo da disciplina? Com a EtnoMatemática, que tem por base a teoria sociointeracionista pode-se compreender um ensino de Matemática em que há contextualização, assim como, o uso de materiais concretos e situações reais torna a aula mais criativa e participativa. A Feira de Matemática também é uma das formas que auxiliam o aprendizado significativo. Este artigo tem como objetivos apresentar uma alternativa de contextualização dos conteúdos matemáticos a fim de conduzir a uma aprendizagem de modo significativo e demonstrar através de atividades práticas como aplicar em sala de aula estes conceitos. Ele se desenvolve através de uma pesquisa bibliográfica que embasa a construção de atividade prática contextualizada, com o uso de material concreto e a possibilidade de ser aplicada em sala de aula. A execução da proposta serve como apoio a outros profissionais da educação que procuram em sua prática na sala de aula desenvolver aulas mais motivadoras e reflexivas.
CONTRIBUIÇÕES DA DISCIPLINA DIVERSIDADE CULTURAL E PRÁTICAS SOCIAIS URBANAS A FAVOR DA INCLUSÃO. UMA VISÃO GERAL INTERDISCIPLINAR
Authors: Ferreira Márcia Vales
Published: September 2020

O presente artigo consiste em uma discussão preliminar acerca do individualismo urbano, diversidade cultural e prática social interdisciplinar inclusiva e colaborativa. Partindo de reflexões da disciplina Diversidade Cultural e Prática Social Urbana cursada no Mestrado em Humanidades, Culturas e Artes (PPGHCA/UNIGRANRIO, 2017), o trabalho procura na interdisciplinaridade os fundamentos para promover reflexões sobre a inclusão. O estudo teórico representa o revigoramento da temática interdisciplinaridade na educação, acerca dos processos inclusivos a partir de reflexões fomentadas pela disciplina citada anteriormente. Vamos considerar o projeto de dissertação desenvolvido em 2017, que apresenta em sua introdução o contexto excludente da Educação Especial, resistindo ferozmente até sua gradativa construção num perfil inclusivo. Observamos através do percurso histórico e da atual conjuntura das políticas de educação inclusiva a luta autêntica, provocando uma forma de resistência nos espaços escolares através da cultura. Aspectos esses que compreendemos ser de suma importância para os espaços educacionais acerca da reflexão da implantação da Lei da Educação Especial. Neste prisma, o artigo faz uma interseção teórica entre as ideias de Richard Sennett (2003), George Simmel (1976; 1987; 2005), Geertz Cliford (1976) e outros autores correlatos ao tema. Para tanto, introduzimos o artigo fazendo o paralelo com a disciplina Diversidade Cultural e Práticas Sociais Urbanas a partir da contextualização sobre a interdisciplinaridade e posteriormente a maneira colaborativa pela qual entendemos e trabalhamos inclusão no contexto educacional.
LEITURA CRÍTICA DE IMAGENS EM LÍNGUA PORTUGUESA: UMA PROPOSTA DE ATIVIDADE PEDAGÓGICA A PARTIR DOS APORTES TEÓRICOS DA GRAMÁTICA DO DESIGN VISUAL
Authors: Siqueira Jakeline , Maciel Alda Maria Coimbra Aguilar
Published: September 2020

Este trabalho apresenta um produto educacional de uma pesquisa desenvolvida no Mestrado Profissional em Práticas de Educação Básica do Colégio Pedro II. Esse artigo está organizado em cinco partes. Quatro partes que tratam dos aportes teóricos, quais sejam teorias modernas que tratam dos conceitos de metáfora, fundamentos da Linguística Sistêmico-Funcional (LSF), pressupostos da Gramática do Design Visual (GDV) de Kress e van Leeuwen e o gênero história em quadrinhos (HQ). Uma seção que apresenta a proposta de atividade pedagógica com foco no desenvolvimento da habilidade de leitura crítica de imagens a partir de pressupostos da GDV. Por fim, discutimos alguns resultados da aplicação desse produto educacional em aulas de Língua Portuguesa de turmas de 6º ano do Ensino Fundamental da Rede Municipal do Rio de Janeiro. Pretende-se, assim, compartilhar uma possibilidade de estratégia pedagógica inovadora para a leitura crítica de textos multimodais, circulantes na modernidade.
O ENSINO EM ZOOLOGIA E O SUL DE MINAS GERAIS: UMA ANÁLISE DAS ABORDAGENS DOS LIVROS DIDÁTICOS ADOTADOS EM ITAJUBÁ/MG
Authors: De Azevedo Hugo José C.C. , De Oliveira Paloma Rezende , Dos Santos Janaína Roberta
Published: September 2020

O livro didático é um recurso amplamente utilizado pelas escolas públicas com afinalidade de ser fonte de informação na sala de aula , tanto dos discentes quanto dos docentes. Cada livro possui um tipo de abordagem de determinado conteúdo, o qual tem relação direta com a formação do aluno enquanto cidadão, uma vez que participa do processo de constituição tanto de conceitos quanto de va lores que os estudantes levarão para a vida cotidiana. No que tange ao E nsino de Z oologia, interessou entender de que modo os livros didáticos utilizados pelas escolas públicas de ensino médio de uma cidade sul mineira abordam o conteúdo de Z oologia obser vando um alto conteúdo de abordagens pouco significativas para a modalidade de ensino formal desta ciência.Subsidiaram esta análise documental e de cunho bibliográfico e exploratório os estudos de De Azevedo (2019); De Azevedo et al ( Santos e C arneiro (2006) 2006); Peres ( 2014); P ereira ( 2012); Vasconcelos e Souto (2003 ); Santos et al (2016); Lopes e Vasconcelos (2012) 2012). A técnica selecionada para tal análise foi a “Análise de Conteúdo” (BARDIN, 2011), que pode ser compreendida por técnicas sistêmicas que descrevem as mensagens e atitudes atreladas ao contexto.
Rola sporu o Bibliotekę Polską w Paryżu w stosunkach polsko-francuskich w latach 1945–1980
Authors: Jarosz Dariusz , Pasztor Maria
Published: September 2020

Biblioteka Polska w Paryżu po II wojnie światowej stała się przedmiotem istotnego sporu w stosunkach kulturalnych między Polską a Francją. Biblioteka założona została w 1838 r. przez środowiska emigracyjne, a w 1891 r. jej własność została scedowana na Polską Akademię Umiejętności. Status prawny tej instytucji skomplikował się w 1945 r. w momencie, w którym 13 czerwca ówczesny dyrektor placówki Franciszek Pułaski podpisał z paryskim przedstawicielem Zjednoczenia Polskiego Rzymsko-Katolickiego w Ameryce akt notarialny wydzierżawienia Biblioteki tejże organizacji na 18 lat. W tym czasie, w Polsce komuniści powołali Tymczasowy Rząd Jedności Narodowej, który został uznany przez Francję, dzięki czemu nawiązano stosunki dyplomatyczne z Polską Ludową. Skomplikowało to sytuację Biblioteki, a sprawa stała się przedmiotem kontrowersji między Warszawą a Paryżem.
Pediatric acute lymphoblastic leukemia
Authors: Inaba Hiroto , Mullighan Charles G.
Published: September 2020

The last decade has witnessed great advances in our understanding of the genetic and biological basis of childhood acute lymphoblastic leukemia (ALL), the development of experimental models to probe mechanisms and evaluate new therapies, and the development of more efficacious treatment stratification. Genomic analyses have revolutionized our understanding of the molecular taxonomy of ALL, and these advances have led the push to implement genome and transcriptome characterization in the clinical management of ALL to facilitate more accurate risk-stratification and, in some cases, targeted therapy. Although mutation- or pathway-directed targeted therapy (e.g., using tyrosine kinase inhibitors to treat Philadelphia chromosome [Ph]-positive and Phlike B-cell-ALL) is currently available for only a minority of children with ALL, many of the newly identified molecular alterations have led to the exploration of approaches targeting deregulated cell pathways. The efficacy of cellular or humoral immunotherapy has been demonstrated with the success of chimeric antigen receptor T-cell therapy and the bispecific engager blinatumomab in treating advanced disease. This review describes key advances in our understanding of the biology of ALL and optimal approaches to risk-stratification and therapy, and it suggests key areas for basic and clinical research.
The Reve’s Puzzle with an Evildoer Disc
Authors: Majumdar AAK
Published: September 2020

This paper considers a variant of the Reve’s puzzle with n (≥1) discs and an evildoer, which can be placed directly on top of a smaller disc any number of times. Denoting by E(n) the minimum number of moves required to solve the new variant, we give a scheme to find the optimality equation satisfied by E(n). We then find an explicit form of E(n).

Journal of Bangladesh Academy of Sciences, Vol. 44, No. 1, 53-58, 2020
PENGEMBANGAN SISTEM INFORMASI AKADEMIK KURIKULUM 2013 BERBASIS WEB PADA SDN TANGKIL 03 WLINGI - BLITAR
Authors: Fajar Malik , Dwanoko Yoyok Seby
Published: September 2020

SDN Tangkil 03 Wlingi - Blitar merupakan salah satu sekolah dari sekolah di Indonesia yang sudah menerapkan kurikulum terbaru yaitu Kurikulum 2013. Aplikasi ini berbasis Microsoft Excel dengan setiap wali kelas berbeda-beda aplikasi yang digunakan berdasarkan tingkat kelas dan semester, jadi dalam satu kelas terdapat dua aplikasi yaitu untuk sester ganjil dan genap. Pada aplikasi Microsoft Excel kurikulum 2013 terdapat beberapa kendala, diantarannya file–file nilai siswa disimpan pada masing–masing wali kelas berdasarkan semester. Hal ini dikhawatirkan file akan rentan hilang yang diakibatkan beberapa faktor, yaitu rentan terkena Virus, aplikasi terhapus secara tidak sengaja dan lain–lain. Berdasarkan penelitian tersebut maka penulis membuat suatu pengembangan sistem infromasi penilaian akademik siswa kurikulum 2013 berbasis web untuk membantu proses penilaian akademik siswa pada SDN Tangkil 03 Wlingi - Blitar, agar data penilaian siswa disimpan secara terpusat. Metodologi yang digunakan dalam membangun sistem ini adalah dengan menggunakan model waterfall.
Budget Impact Analysis of anakinra in the treatment of patients with Still’s Disease
Authors: Ravasio Roberto , Giacomelli Roberto , Bianchi Stefano
Published: September 2020

Background: Anakinra, canakinumab and tocilizumab are all effective alternative treatment choice in patients with Still’s disease including both systemic juvenile idiopathic arthritis (SJIA) adult onset Still’s disease (AOSD) compared to canakinumab and tocilizumab.

Objective: Aim of this study was to estimate the budget impact of the use of anakinra compared to canakinumab and tocilizumab in the treatment of patients with AOSD or SJIA.

Methods: Considering the perspective of the Italian National Health Service (iNHS), a budget impact model (BIM) was developed to estimate the drugs costs of anakinra, canakinumab and tocilizumab up to 12 months. The BIM showed the difference of drug expenditure generated by the base case calculated for current prescription volumes, and for different prescription volume scenarios with increased anakinra prescription. Key variables were tested in the sensitivity analysis.

Results: Compared to the current scenario for SJIA, an increase in the market share of anakinra (40% or 50%) would lead to a reduction in the drug expenditure sustained by iNHS (-€1,118,005 [-12.7%] or -€2,054,502 [-23.4%]). Compared to the current scenario for AOSD, an increase in the market share of anakinra (40% or 50%) would lead to a reduction in the drug expenditure sustained by iNHS (-€4,024,585 [-13.5%] or -€8,049,169 [-27.0%]).

Conclusion: According to the present analysis, the use of anakinra, as an alternative to canakinumab or tocilizumab in patients with AOSD or SJIA, could represent a cost-saving option for the iNHS.
Significance of anecdotes for historical perspective: black bear predation on sea turtle eggs
Authors: Bjorndal KA
Published: September 2020

In his April 2010 TED talk on the shifting baseline syndrome, Daniel Pauly warned us that ‘we transform the world, but we don’t remember it.’ This lapse is the greatest obstacle to understanding and restoring the structure and function of ecosystems transformed by anthropogenic effects over past centuries or even over the past few decades. Historical anecdotes can be a powerful tool to address gaps in our knowledge of the past. I present a case study to demonstrate the use of anecdotes to reveal the extensive predation by black bearsUrsus americanuson sea turtle eggs in Florida, USA. Until the late 1800s, bears were major predators on eggs deposited by the large sea turtle aggregations nesting on the east coast of Florida. However, this past source of mortality, and the resulting substantial transport of nutrients from marine to terrestrial habitats via the bears, are largely unknown today. By the early 1900s, the great influx of humans to the east coast of Florida quickly decimated the bear populations by hunting and habitat degradation. Without historical anecdotes, knowledge of the extensive predation by black bears on sea turtle eggs in Florida would have been lost.