bluuebunny/crossref_metadata_2025 huggingface dataset:
Latency Reversal 2.0: Giving the Immune System a Seat at the Table
Authors: Singh Vidisha , Dashti Amir , Mavigner Maud , Chahroudi Ann
Published: January 2021

Purpose of Review

For most people living with HIV (PLWH), treatment with effective antiretroviral therapy (ART) results in suppression of viremia below the limit of detection of clinical assays, immune reconstitution, reduced immune activation, avoidance of opportunistic infections, and progression to AIDS. However, ART alone is not curative, and HIV persists in a non-replicating, latent form. In this review, we provide a historical perspective on non-specific latency reversal approaches (LRA 1.0) and summarize recent advances in latency reversal strategies that target specific signaling pathways within CD4+ T cells or other immune cells to induce expression of latent HIV (immune-based latency reversal, or LRA 2.0).

Recent Findings

The HIV reservoir is primarily composed of latently infected CD4+ T cells carrying integrated, replication-competent provirus that can give rise to rebound viremia if ART is stopped. Myeloid lineage cells also contribute to HIV latency in certain tissues; we focus here on CD4+ T cells as a sufficient body of evidence regarding latency reversal in myeloid cells is lacking. The immunomodulatory LRA 2.0 approaches we describe include pattern recognition receptor agonists, immune checkpoint inhibitors, non-canonical NF-kB stimulation, and transient CD8+ lymphocyte depletion, along with promising combination strategies. We highlight recent studies demonstrating robust latency reversal in nonhuman primate models.

While significant strides have been made in terms of virus reactivation from latency, initial hopes for latency reversal alone to result in a reduction of infected cells, through viral cytopathic effect or an unboosted immune system, have not been realized and it seems clear that even effective latency reversal strategies will need to be paired with an approach that facilitates immune recognition and clearance of cells containing reactivated virus.
Investigating hesperetin nanocrystals with tailor-made sizes for the prevention and treatment of Alzheimer’s disease
Authors: Stahr Pascal-L. , Grewal Rekha , Eckert Gunter P. , Keck Cornelia M.
Published: January 2021

Poor aqueous solubility of drug substances is associated with poor bioavailability and thus hampers the effective use of many potent active pharmaceutical ingredients. Various strategies to overcome poor solubility are available, whereby drug nanocrystals represent one of the most powerful formulation strategies to enhance the kinetic solubility and dissolution rate of poorly soluble drugs. Nanocrystals are simply obtained by milling large-sized drug powders to sizes < 1 µm. The so obtained nanocrystals possess an increased dissolution rate and kinetic solubility when compared with larger-sized bulk material. The aim of this study was to produce differently sized hesperetin nanocrystals and to investigate the influence of nanocrystal size on the bioefficacy of the natural antioxidant hesperetin in two cell culture models for the prevention and treatment of Alzheimer’s disease. Results showed that the testing of poorly soluble compounds is challenging and requires incredibly careful characterization. Reasons for this are possible changes of the formulations in cell culture media which can occur due to various reasons. If the changes are not considered, results obtained can be misleading and even lead to a false interpretation of the results obtained. Besides, results demonstrate the increase in dissolution rate with decreasing particle size that is especially pronounced with particle sizes < 200 nm. Data also provide clear evidence that smaller nanocrystals with higher kinetic solubility possess higher antioxidant capacity. This results in lower amounts of free radicals in the cell culture models, suggesting that hesperetin nanocrystals, that improve the poor aqueous solubility of hesperetin, are promising for the prevention and treatment of Alzheimer’s disease.

Graphical abstract

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Dependence of the Generation Behavior of Charged Nanoparticles and Ag Film Growth on Sputtering Power during DC Magnetron Sputtering
Authors: Jang Gil Su , Kim Du Yun , Hwang Nong-Moon
Published: January 2021

Effects of sputtering power on the deposition rate and microstructure, crystallinity, and electrical properties of Ag films during direct current (DC) magnetron sputtering are investigated. Thin films (~ 100 nm) are deposited at sputtering powers of 10, 20, 50, 100, 200 and 300 W and analyzed by field-emission scanning electron microscopy (FESEM), X-ray diffraction (XRD), transmission electron microscopy (TEM) and a four-point probe. The film deposited at a sputtering power of 10 W has the lowest growth rate, but the highest crystalline quality, with the lowest full width at half maximum (FWHM) and the lowest resistivity. The film deposited at a sputtering power of 200 W has the highest growth rate, and the second best crystalline quality in view of FWHM and resistivity. The film deposited at a sputtering power of 50 W has the moderate growth rate, and the worst crystalline quality in view of FWHM and resistivity. High-resolution TEM observations reveal that films deposited at sputtering powers of 10 and 200 W have far fewer defects, such as grain boundaries, dislocations and stacking faults than those deposited at a sputtering power of 50 W. Such deposition behavior could be explained by sputtering power, which affected the generation of the charged nanoparticles. And the high quality of films could be obtained at a high deposition rate, in which charge plays an important role.

Graphic Abstract
A Review on Metal–Organic Framework-Derived Porous Carbon-Based Novel Microwave Absorption Materials
Authors: Zhang Zhiwei , Cai Zhihao , Wang Ziyuan , Peng Yaling , Xia Lun , Ma Suping , Yin Zhanzhao , Huang Yi
Published: January 2021

The development of microwave absorption materials (MAMs) is a considerable important topic because our living space is crowed with electromagnetic wave which threatens human’s health. And MAMs are also used in radar stealth for protecting the weapons from being detected. Many nanomaterials were studied as MAMs, but not all of them have the satisfactory performance. Recently, metal–organic frameworks (MOFs) have attracted tremendous attention owing to their tunable chemical structures, diverse properties, large specific surface area and uniform pore distribution. MOF can transform to porous carbon (PC) which is decorated with metal species at appropriate pyrolysis temperature. However, the loss mechanism of pure MOF-derived PC is often relatively simple. In order to further improve the MA performance, the MOFs coupled with other loss materials are a widely studied method. In this review, we summarize the theories of MA, the progress of different MOF-derived PC‑based MAMs, tunable chemical structures incorporated with dielectric loss or magnetic loss materials. The different MA performance and mechanisms are discussed in detail. Finally, the shortcomings, challenges and perspectives of MOF-derived PC‑based MAMs are also presented. We hope this review could provide a new insight to design and fabricate MOF-derived PC-based MAMs with better fundamental understanding and practical application.
Impact investments: a call for (re)orientation
Authors: Busch Timo , Bruce-Clark Peter , Derwall Jeroen , Eccles Robert , Hebb Tessa , Hoepner Andreas , Klein Christian , Krueger Philipp , Paetzold Falko , Scholtens Bert , Weber Olaf
Published: January 2021

Practitioners and academics have been using different terms to describe investments in the sustainability context. The latest inflationary term is impact investments—investments that focus on real-world changes in terms of solving social challenges and/or mitigating ecological degradation. At the core of this definition is an emphasis on transformational changes. However, the term impact investment is often used interchangeably for any investment that incorporates environmental, social, and governance (ESG) aspects. In the latter instance, achieving transformational change is not the main purpose of such investments, which therefore carries the risk of impact washing (akin to “green washing”). To offer (re-)orientation from an academic perspective, we derive a new typology of sustainable investments. This typology delivers a precise definition of what impact investments are and what they should cover. As one central contribution, we propose distinguishing between impact-aligned investments and impact-generating investments. Based on these insights, we hope to lay the foundation for future research and debates in the field of impact investing by practitioners, policymakers, and academics alike.
A Prospective Economic Evaluation of Rapid Endovascular Therapy for Acute Ischemic Stroke
Authors: Sevick Laura K. , Demchuk Andrew M. , Shuaib Ashfaq , Smith Eric E. , Rempel Jeremy L. , Butcher Kenneth , Menon Bijoy K. , Jeerakathil Thomas , Kamal Noreen , Thornton John , Williams David , Poppe Alexandre Y. , Roy Daniel , Goyal Mayank , Hill Michael D. , Clement Fiona
Published: January 2021

Background:

During the Randomized Assessment of Rapid Endovascular Treatment (EVT) of Ischemic Stroke (ESCAPE) trial, patient-level micro-costing data were collected. We report a cost-effectiveness analysis of EVT, using ESCAPE trial data and Markov simulation, from a universal, single-payer system using a societal perspective over a patient’s lifetime.

Methods:

Primary data collection alongside the ESCAPE trial provided a 3-month trial-specific, non-model, based cost per quality-adjusted life year (QALY). A Markov model utilizing ongoing lifetime costs and life expectancy from the literature was built to simulate the cost per QALY adopting a lifetime horizon. Health states were defined using the modified Rankin Scale (mRS) scores. Uncertainty was explored using scenario analysis and probabilistic sensitivity analysis.

Results:

The 3-month trial-based analysis resulted in a cost per QALY of $201,243 of EVT compared to the best standard of care. In the model-based analysis, using a societal perspective and a lifetime horizon, EVT dominated the standard of care; EVT was both more effective and less costly than the standard of care (−$91). When the time horizon was shortened to 1 year, EVT remains cost savings compared to standard of care (∼$15,376 per QALY gained with EVT). However, if the estimate of clinical effectiveness is 4% less than that demonstrated in ESCAPE, EVT is no longer cost savings compared to standard of care.

Conclusions:

Results support the adoption of EVT as a treatment option for acute ischemic stroke, as the increase in costs associated with caring for EVT patients was recouped within the first year of stroke, and continued to provide cost savings over a patient’s lifetime.

Clinical Trial Registration: NCT01778335
Highly efficient difference-frequency generation for mid-infrared pulses by passively synchronous seeding
Authors: Huang Kun , Wang Yinqi , Fang Jianan , Chen Huaixi , Xu Minghang , Hao Qiang , Yan Ming , Zeng Heping
Published: January 2021

We have proposed and experimentally demonstrated a novel scheme for efficient mid-infrared difference-frequency generation based on passively synchronized fiber lasers. The adoption of coincident seeding pulses in the nonlinear conversion process could substantially lower the pumping threshold for mid-infrared parametric emission. Consequently, a picosecond mid-infrared source at 3.1 μm was prepared with watt-level average power, and a maximum power conversion efficiency of 77% was realized from pump to down-converted light. Additionally, the long-term stability of generated power was manifested with a relative fluctuation as low as 0.17% over one hour. Thanks to the all-optical passive synchronization and all-polarization-maintaining fiber architecture, the implemented laser system was also featured with simplicity, compactness and robustness, which would favor subsequent applications beyond laboratory operation.
Development and evaluation of image-series for portion size estimation in dietary assessment among adults
Authors: Salvesen Lorentz , Engeset Dagrun , Øverby Nina C. , Medin Anine C.
Published: January 2021

Portion size images are advantageous in dietary assessment. The aim of the present study was to develop and validate new culturally specific image-series for portion size estimation to be used in a new Norwegian version of a British web-based dietary assessment tool (myfood24). Twenty-three image-series of different foods, each containing seven portion size images, were created and validated in a group of adults (n41, 58 % female) aged 19–44 (median 23), out of which 63 % had higher (tertiary) education. The participants compared 46 portions of pre-weighed foods to the portion size images (1886 comparisons in total). Portion size estimations were either classified as correct, adjacent or misclassified. The weight discrepancy in percentage between the chosen and the correct portion size image was also calculated. Mann–WhitneyUtests were used to explore if portion size estimation accuracy differed across sample characteristics, or if it depended on how the foods were presented. For thirty-eight of the forty-six presented food items, the participants selected the correct or adjacent portion size image 98 % on average. The remaining eight food items were on average misclassified by 27 % of the participants. Overall, a mean weight discrepancy of 2⋅5 % was observed between the chosen and the correct portion size images. Females estimated portion size more accurately than males (P= 0⋅019). No other significant differences in estimation accuracy were observed. In conclusion, the new image-series performed satisfactorily, except for the image-series depicting bread, caviar spread and marzipan cake, which will be altered. The present study demonstrates the importance of validating portion size estimation tools.
Justice: The Racial Motive We All Have and Need
Authors: Wilson David C.
Published: January 2021

This essay posits that justice is the core value epitomizing our moment. Justice is violated when positive outcomes are undeserved, and the felt sense of injustice motivates a need for retribution. Because politics involves allocation (distribution and redistribution), deservingness is a core appraisal of “who gets what” and therefore justice is fundamental for politics. This is especially germane to race, ethnicity, and politics scholars. I present a few core tenets of justice theory, and argue that political science can take advantage of the moment to engage the concept of justice; especially as it relates to the study of racial attitudes and the identification of racial enablers—those ostensible non-racists who facilitate the status quo. Summarily, I propose that justice can unify debates over prejudice and politics, and advance our scholarly understanding of how well-intentioned people—regardless of their identities, or ideological or partisan labels—can facilitate racism, racial inequality, and injustice.
Racialized Anti-Statism and the Failure of the American State
Authors: Miller Lisa L.
Published: January 2021

How well do we understand the political moment in which we find ourselves in the wake of the Trump presidency? The United States has long failed to keep up with its democratic peers on a wide range of social outcomes but the struggle to keep a pandemic at bay, coupled with increases in social violence and new uprisings over state violence have exposed the failures of the American state in a stark manner. While research on political attitudes continues to offer crucial insights into what Americans want from government and how race, class, and gender are formative dimensions of public opinion, we know considerably less about how these attitudes intersect with the highly fragmented and decentralized nature of U.S. political institutions. In this essay, I offer a framework for understanding our current moment through the lens of racialized anti-statism and state failure. I focus on the intersection of two reinforcing and overlapping features of the U.S. political system: the highly fragmented, veto-laden structure of American politics and the persistence of anti-egalitarian movements. By situating our analysis at this intersection, we observe the convergence of racial and economic power in an anti-statist alliance that undermines American state-building, even when large majorities of Americans favor it.
Direct and spillover impacts of community-based seed production: Quasi-experimental evidence from Nepal
Authors: Gautam Shriniwas , Rahut Dil Bahadur , Erenstein Olaf , KC Dilli Bahadur
Published: January 2021

Maize production is central to rural livelihoods in the hills of Nepal. Access to affordable improved maize seed has long been a barrier to productivity gains and livelihood improvement. This study evaluates the direct and indirect (spillover) impacts of a community-based seed production program in Nepal using a quasi-experimental method for selected outcome indicators. Our results show that community-based seed production provides a significant positive direct impact on maize income and female leadership opportunities. The impacts were particularly favorable for disadvantaged households (HHs) from lower castes and HHs that owned less land. There is also strong evidence of spillover impacts on improved seed adoption, yield, and household maize self-sufficiency. Community-based seed production thereby could help Nepal attain cereal self-sufficiency and nutritional security as envisioned in the national agricultural development strategy and seed vision.
Introduction to a Forum on Migration in Early Medieval China
Authors: Huang Wen-Yi , Tian Xiaofei
Published: January 2021

How do we think about migration? This question was the topic of the first installment of the 2019 Tanner Lectures on Human Values, given by the exiled Russian journalist Masha Gessen, at Harvard University. Gessen, who had reported on immigrants, began with a story of a Montenegro man whose family fled to the United States when he was five. Then they told a second story, then a third, followed by fifty-four more stories of individuals’ sorrows, despair, and dreams. Gessen's intent was to bring to life individual migrants, underscoring their diverse experiences. Individuality and complexity matter, because too often, people on the move are reduced to numbers in the news and in the eyes of governments.
A Journey across Many Realms: The Shi Jun Sarcophagus and the Visual Representation of Migration on the Silk Road
Authors: Xu Jin
Published: January 2021

The Shi Jun sarcophagus (580 CE), a house-shaped stone coffin of a Sogdian immigrant couple, is one of the most important Silk Road discoveries ever made (figure 1). Excavated in Xi'an (Shaanxi Province, China) in 2003, it belongs to a group of sarcophagi created for Sogdian community leaders in sixth-century China that have been uncovered over the course of the past century, primarily in the last two decades. The Shi Jun sarcophagus sets itself apart from the others with an epitaph inscribed in both Chinese and Sogdian. The epitaph recounts the migration of a Sogdian couple from Central Asia to the Chinese heartland. Even more unusual than this inscription is the exterior of the sarcophagus, which is carved with a continuous sequence of narrative reliefs. These represent the deceased's multifaceted journey on the Silk Road.
Seasonal variation of water-column light utilization efficiency for primary production in Saroma-ko Lagoon
Authors: Shiomoto Akihiro , Kamuro Yushi
Published: January 2021

In Saroma-ko Lagoon, where scallop aquaculture is a thriving commercial activity, monitoring primary production is essential for determining the amount of scallops that can be farmed. Using the primary production data obtained so far, we calculated Ψ, an index of water-column light utilization efficiency, and clarified its seasonal variation. Ψ tended to be lower in the spring bloom season (February–April), and higher in the late autumn to winter (October–December). Low chlorophyll-normalized production, an index of growth rate, resulted in lower values, while low daily irradiance resulted in higher values. The values of Ψ from our study had a range of 0.05–1.42 gC gChl-a−1 mol photons−1 m2 (N = 56). These values were within the previously reported range of 0.07–1.92 (gC gChl-a−1 mol photons−1 m2) for seawater and fresh water worldwide. Therefore, it is likely that Ψ varies from 0.05–2 gC gChl-a−1 mol photons−1 m2, being affected by conditions of phytoplankton growth and sunlight intensity, regardless of whether samples are collected from seawater or fresh water. Using the median Ψ value of 0.45 gC gChl-a−1 mol photons−1 m2 obtained in this study, primary production was 0.3–3.5 times the actual production at Saroma-ko Lagoon. Using this method, primary production can be easily and constantly monitored, facilitating the sustainable development of scallop aquaculture.
Ecological momentary facial emotion recognition in psychotic disorders
Authors: Depp Colin A. , Kamarsu Snigdha , Filip Tess F. , Parrish Emma M. , Harvey Philip D. , Granholm Eric L. , Chalker Samantha , Moore Raeanne C. , Pinkham Amy
Published: January 2021

Background

Cognitive tasks delivered during ecological momentary assessment (EMA) may elucidate the short-term dynamics and contextual influences on cognition and judgements of performance. This paper provides initial validation of a smartphone task of facial emotion recognition in serious mental illness.

Methods

A total of 86 participants with psychotic disorders (non-affective and affective psychosis), aged 19–65, were administered in-lab ‘gold standard’ affect recognition, neurocognition, and symptom assessments. They subsequently completed 10 days of the mobile facial emotion recognition task, assessing both accuracy and self-assessed performance, along with concurrent EMA of psychotic symptoms and mood. Validation focused on task adherence and predictors of adherence, gold standard convergent validity, and symptom and diagnostic group variation.

Results

The mean rate of adherence to the task was 79%; no demographic or clinical variables predicted adherence. Convergent validity was observed with in-lab measures of facial emotion recognition, and no practice effects were observed on the mobile facial emotion recognition task. EMA reports of more severe voices, sadness, and paranoia were associated with worse performance, whereas mood more strongly associated with self-assessed performance.

Conclusion

The mobile facial emotion recognition task was tolerated and demonstrated convergent validity with in-lab measures of the same construct. Social cognitive performance, and biased judgements previously shown to predict function, can be evaluated in real-time in naturalistic environments.
Development of a probability calculator for psychosis risk in children, adolescents, and young adults
Authors: Moore Tyler M. , Calkins Monica E. , Rosen Adon F. G. , Butler Ellyn R. , Ruparel Kosha , Fusar-Poli Paolo , Koutsouleris Nikolaos , McGuire Philip , Cannon Tyrone D. , Gur Ruben C. , Gur Raquel E.
Published: January 2021

Background

Assessment of risks of illnesses has been an important part of medicine for decades. We now have hundreds of ‘risk calculators’ for illnesses, including brain disorders, and these calculators are continually improving as more diverse measures are collected on larger samples.

Methods

We first replicated an existing psychosis risk calculator and then used our own sample to develop a similar calculator for use in recruiting ‘psychosis risk’ enriched community samples. We assessed 632 participants age 8–21 (52% female; 48% Black) from a community sample with longitudinal data on neurocognitive, clinical, medical, and environmental variables. We used this information to predict psychosis spectrum (PS) status in the future. We selected variables based on lasso, random forest, and statistical inference relief; and predicted future PS using ridge regression, random forest, and support vector machines.

Results

Cross-validated prediction diagnostics were obtained by building and testing models in randomly selected sub-samples of the data, resulting in a distribution of the diagnostics; we report the mean. The strongest predictors of later PS status were the Children's Global Assessment Scale; delusions of predicting the future or having one's thoughts/actions controlled; and the percent married in one's neighborhood. Random forest followed by ridge regression was most accurate, with a cross-validated area under the curve (AUC) of 0.67. Adjustment of the model including only six variables reached an AUC of 0.70.

Conclusions

Results support the potential application of risk calculators for screening and identification of at-risk community youth in prospective investigations of developmental trajectories of the PS.
Maternal mental health during the COVID-19 lockdown in China, Italy, and the Netherlands: a cross-validation study
Authors: Guo Jing , De Carli Pietro , Lodder Paul , Bakermans-Kranenburg Marian J. , Riem Madelon M. E.
Published: January 2021

Background

The coronavirus disease 2019 (COVID-19) pandemic had brought negative consequences and new stressors to mothers. The current study aims to compare factors predicting maternal mental health during the COVID-19 lockdown in China, Italy, and the Netherlands.

Methods

The sample consisted of 900 Dutch, 641 Italian, and 922 Chinese mothers (age M = 36.74, s.d. = 5.58) who completed an online questionnaire during the lockdown. Ten-fold cross-validation models were applied to explore the predictive performance of related factors for maternal mental health, and also to test similarities and differences between the countries.

Results

COVID-19-related stress and family conflict are risk factors and resilience is a protective factor in association with maternal mental health in each country. Despite these shared factors, unique best models were identified for each of the three countries. In Italy, maternal age and poor physical health were related to more mental health symptoms, while in the Netherlands maternal high education and unemployment were associated with mental health symptoms. In China, having more than one child, being married, and grandparental support for mothers were important protective factors lowering the risk for mental health symptoms. Moreover, high SES (mother's high education, high family income) and poor physical health were found to relate to high levels of mental health symptoms among Chinese mothers.

Conclusions

These findings are important for the identification of at-risk mothers and the development of mental health promotion programs during COVID-19 and future pandemics.
Pragmatic ordering: Informality, experimentation, and the maritime security agenda
Authors: Bueger Christian , Edmunds Timothy
Published: January 2021

The question of when and how international orders change remains a pertinent issue of International Relations theory. This article develops the model of pragmatic ordering to conceptualise change. The model of pragmatic ordering synthesises recent theoretical arguments for a focus on ordering advanced in-practice theory, pragmatist philosophy, and related approaches. It also integrates evidence from recent global governance research. We propose a five-stage model. According to the model, once a new problem emerges (problematisation), informality allows for experimenting with new practices and developing new knowledge (informalisation and experimentation). Once these experimental practices become codified, and survive contestation, they increasingly settle (codification) and are spread through learning and translation processes (consolidation). We draw on the rise of the maritime security agenda as a paradigmatic case and examine developments in the Western Indian Ocean region to illustrate each of these stages. The article draws attention to the substantial reorganisation of maritime space occurring over the past decade and offers an innovative approach for the study of orders and change.
Dynamic Modeling and Control of a Novel One-Legged Hopping Robot
Authors: Khakpour Komarsofla Amin , Azadi Yazdi Ehsan , Eghtesad Mohammad
Published: January 2021

In this article, a novel mechanism for planar one-legged hopping robots is proposed. The robot consists of a flat foot which is pinned to the leg and a reciprocating mass which is connected to the leg via a prismatic joint. The proposed mechanism performs the hopping by transferring linear momentum between the reciprocating mass and its main body. The nonlinear equations of the motion of the robot are derived using the Euler–Lagrange equations. To accomplish a stable jump, appropriate trajectories have been planned. To guarantee a stable response for this nonlinear system, a sliding-mode controller is implemented. The performance of the hopping robot is investigated through numerical simulations. The results confirm the stability of the hopping robot through the jump cycle on a flat surface and in climbing up and down ramp and stairs.
Strengthening patient outcome evidence in health technology assessment: a coproduction approach
Authors: Rasburn Mark , Livingstone Heidi , Scott Sarah E.
Published: January 2021

The National Institute for Health and Care Excellence (NICE) worked with patients and staff from six patient organizations to review existing health technology assessment (HTA) methods and coproduce proposals to improve the following: patient involvement, how patient evidence is identified and considered by committees, and the support offered to patient stakeholders. This engagement identified important factors that HTA bodies need to understand to enable meaningful patient and public involvement (PPI), such as having clearly documented processes, appropriate evidence submission processes, transparent decisions, and suitable support. This work demonstrated the benefits of HTA bodies working collaboratively with patient stakeholders to improve PPI. By doing so, HTA bodies can increase their knowledge and understanding of the barriers faced by patient stakeholders to develop appropriate solutions to remove them. The coproduction approach improved stakeholder engagement methods, provided a better analysis of data, supported the development of meaningful conclusions, and improved stakeholder relationships.
X-ray powder diffraction data for norethisterone enanthate, C27H38O3
Authors: Fan Jingwen , Zha Zhicheng , Wang Qing , Zheng Shoujun
Published: January 2021

X-ray powder diffraction data, unit-cell parameters, and space group for norethisterone enanthate, C27H38O3, are reported [a = 6.191(4) Å, b = 12.711(3) Å, c = 31.396(2) Å, α = 90°, β = 90°, γ = 90°, unit-cell volume V = 2471.16 Å3, Z = 4, ρcal = 1.104 g cm−3, and space group P212121]. All measured lines were indexed and are consistent with the P212121 space group. No detectable impurities were observed.
Impact of PD-1 gene polymorphism and its interaction with tea drinking on susceptibility to tuberculosis
Authors: Wang Jing , Wang Mian , Li Zihao , Wu Xinyin , Zhang Xian , Julius Abesig , Zhong Hua , Huang Xin , Chen Mengshi , Tan Hongzhuan , Yi Hengzhong
Published: January 2021

The aim of this study was to explore the impact of polymorphism of PD-1 gene and its interaction with tea drinking on susceptibility to tuberculosis (TB). A total of 503 patients with TB and 494 controls were enrolled in this case–control study. Three single-nucleotide polymorphisms of PD-1 (rs7568402, rs2227982 and rs36084323) were genotyped and unconditional logistic regression analysis was used to identify the association between PD-1 polymorphism and TB, while marginal structural linear odds models were used to estimate the interactions. Genotypes GA (OR 1.434), AA (OR 1.891) and GA + AA (OR 1.493) at rs7568402 were more prevalent in the TB patients than in the controls (P < 0.05). The relative excess risk of interaction (RERI) between rs7568402 of PD-1 genes and tea drinking was −0.3856 (95% confidence interval −0.7920 to −0.0209, P < 0.05), which showed a negative interaction. However, the RERIs between tea drinking and both rs2227982 and rs36084323 of PD-1 genes were not statistically significant. Our data demonstrate that rs7568402 of PD-1 genes was associated with susceptibility to TB, and there was a significant negative interaction between rs7568402 and tea drinking. Therefore, preventive measures through promoting the consumption of tea should be emphasised in the high-risk populations.
The dynamics of two-session interviews with suspected victims of abuse who are reluctant to make allegations
Authors: Hershkowitz Irit , Lamb Michael E. , Blasbalg Uri , Karni-Visel Yael
Published: January 2021

Supportive forensic interviews conducted in accordance with the National Institute of Child Health and Human Development Revised Protocol (RP) help many alleged victims describe abusive experiences. When children remain reluctant to make allegations, the RP guides interviewers to (a) focus on rapport building and nonsuggestive support in a first interview, and (b) plan a second interview to allow continued rapport building before exploring for possible abuse. We explored the dynamics of such two-session RP interviews. Of 204 children who remained reluctant in an initial interview, we focused on 104 who made allegations when re-interviewed a few days later. A structural equation model revealed that interviewer support during the first session predicted children's cooperation during the rapport-building phase of the second session, which, in turn, predicted more spontaneous allegations, which were associated with the interviewers’ enhanced use of open-ended questions. Together, these factors mediated the effects of support on children's free recall of forensically important information. This highlighted the importance of emphasizing rapport with reluctant children, confirming that some children may need more time to build rapport even with supportive interviewers.
Old Norse-derived lexis in multilingual accounts: a case study
Authors: ROIG-MARÍN AMANDA
Published: January 2021

This article on Old Norse represents a fundamental departure from the previous literature on loaned material by examining multilingual documents written in Medieval Latin rather than in monolingual English, namely theDurham Account Rolls(DAR). The potential of this richer and more complex interplay between languages will be further addressed throughout the article, which assesses the different kinds of evidence available for establishing the relative plausibility for a word being derived from ON. Dance's (2013, 2018, 2019) taxonomy will be discussed and applied to multilingual material for the first time. The article concludes with some notes on the main semantic fields to which ON-derived lexis contributed within the multilingual lexical networks of theDAR.
Percentage of energy contribution according to the degree of industrial food processing and associated factors in adolescents (EVA-JF study, Brazil)
Authors: Melo Adriana ST , Neves Felipe S , Batista Aline P , Machado-Coelho George Luiz L , Sartorelli Daniela S , de Faria Eliane R , Netto Michele P , Oliveira Renata MS , Fontes Vanessa S , Cândido Ana Paula C
Published: January 2021

Objective:

To evaluate energetic contribution according to the degree of industrial food processing and its association with sociodemographic, anthropometric, biochemical, clinical and behavioural characteristics in adolescents.

Design:

Cross-sectional study (Adolescent Lifestyle Study). Food consumption was assessed using 24-h dietary recalls, with foods classified by degree of industrial progressing. The usual diet was estimated using the Multiple Source Method. In a linear regression model, the energy percentage (E %) was associated with sociodemographic, anthropometric, biochemical, clinical and behavioural characteristics, after adjustment for sex and age.

Setting:

Juiz de Fora, Brazil.

Participants:

Eight hundred and four adolescents, of both sexes, 14–19 years of age, enrolled in public schools.

Results:

The E % of unprocessed or minimally processed foods corresponded to 43·1 %, processed foods to 11·0 % and the ultraprocessed foods to 45·9 %. E % of unprocessed foods was associated with socio-economic stratum (adjusted β = −0·093; P = 0·032), neck circumference (adjusted β = 0·017; P = 0·049), screen time (adjusted β = −0·247; P = 0·036) and HDL-cholesterol (adjusted β = −0·156; P = 0·003). E % of ultraprocessed foods was associated with socio-economic stratum (adjusted β = 0·118; P = 0·011), screen time (adjusted β = 0·375; P = 0·003), BMI (adjusted β = −0·029; P = 0·025), neck circumference (adjusted β = −0·017; P = 0·028) and HDL-cholesterol (adjusted β = 0·150; P = 0·002).

Conclusions:

There was a high E % of ultraprocessed foods in the diet of the adolescents. Actions are needed to raise the awareness of adopting healthy eating habits.
Changing landscape of nutrition and dietetics research? A bibliographic analysis of top-tier published research in 1998 and 2018
Authors: Yoong Sze Lin , Jackson Jacklyn , Barnes Courtney , Pearson Nicole , Swindle Taren , O’Reilly Sharleen , Tabak Rachel , Belski Regina , Brown Alison , Sutherland Rachel
Published: January 2021

Objective:

The current study sought to describe and compare study type, research design and translation phase of published research in nutrition and dietetic journals in 1998 and 2018.

Design:

This was a repeat cross-sectional bibliographic analysis of Nutrition and Dietetics research. All eligible studies in the top eight Nutrition and Dietetics indexed journals in 1998 and 2018 were included. Two independent reviewers coded each study for research design (study type and study design) and translation phase (T0-T4) of the research using seminal texts in the field.

Setting:

Not relevant.

Participants:

Not relevant.

Results:

The number of publications (1998, n 1030; 2018, n 1016) has not changed over time, but the research type, design and translation phases have. The proportion of intervention studies in 1998 (43·8 %) was significantly higher than 2018 (19·4 %). In 2018, more reviews (46·9 % v. 15·6 % in 1998) and less randomised trials (14·3 % v. 37·8 % in 1998) were published. In regard to translation phase, there was a higher proportion of T2–T4 research in 2018 (18·3 % v. 3·8 % in 1998); however, the proportion of T3/T4 (dissemination, implementation and population-level research) research was still low (<3 %). Our sensitivity analysis with the four journals that remained in the top eight journal across the two time periods found no differences in the research type, design and translation phases across time.

Conclusions:

There was a reduction in intervention and T0 publications, alongside higher publication of clinical study designs over time; however, published T3/T4 research in Nutrition and Dietetics is low. A greater focus on publishing interventions and dissemination and implementation may be needed.
Changes in dominant weeds of wheat in a rice–wheat rotation system as affected by composted manure and straw amendments
Authors: Duan Yunhui , Zhang Haiyan , Han Min , Hong Aimei , Li Yong , Sun Guojun , Gao Pinglei , Sun Yicheng , Ran Wei , Shen Jiahe , Shen Xin , Wu Chenyu , Ji Min
Published: January 2021

A study was conducted to identify whether composted manure and straw amendments (replacement of a portion of chemical fertilizer [50% of the total nitrogen application] with composted pig manure, and straw return [all straw from the previous rice crop] combined with chemical fertilizer) compared with no fertilization and chemical fertilizer only would change the dominant species of wheat-associated weeds as well as influence their growth and seed yield in a rice (Oryza sativaL.)–wheat (Triticum aestivumL.) rotation system. The study was initiated in 2010, and the treatment effects on the species, density, plant height, shoot biomass, seed yield of dominant weeds, and wheat yields were assessed in 2017 and 2018. Fertilization significantly increased the height, density, and yield of wheat, as well as the shoot biomass of wheat-associated weeds, but decreased the weed species number. A total of 17 and 14 weed species were recorded in the experimental wheat fields in 2017 and 2018, respectively. The most dominant weed species were American sloughgrass [Beckmannia syzigachne(Steud.) Fernald] and catchweed bedstraw (Galium aparineL.), which made up more than 64% of the weed community in all treatments. When the chemical fertilizer application was amended with pig manure compost and straw return, the relative abundance ofB. syzigachnesignificantly decreased, while the relative abundance ofG. aparinesignificantly increased. The application of the chemical fertilizer-only treatment resulted in increases in the density, shoot biomass, and seed yield ofB. syzigachne, while the composted manure and straw amendments applied together with chemical fertilizer led to significant increases in the density, shoot biomass, and seed yield ofG. aparine. Consequently, further research on ways to promote greater cropping system diversity will be needed to prevent the selection of weed species that are adapted to a limited suite of crop management practices.
Germination biology of four climatically varied populations of the invasive species African lovegrass (Eragrostis curvula)
Authors: Roberts Jason , Florentine Singarayer , van Etten Eddie , Turville Christopher
Published: January 2021

African lovegrass [Eragrostis curvula (Schrad.) Nees] is a highly invasive C4 perennial grass that threatens global biodiversity. Appropriate management of this species has been hampered by a lack of knowledge concerning its seed ecology, resulting in significant economic and environmental impacts within various environments. Consequently, this study explored the effects of a selection of environmental factors (photoperiod, alternating temperature, pH, and salinity) by analyzing several measures of germination on four geographically distinct populations of E. curvula to assist in its extirpation from infested sites. Seeds were collected in Australia from Maffra and Shepparton, VIC; Tenterfield, NSW; and Midvale, WA. Key results showed that seeds from Maffra (54% vs. 79%), Tenterfield (38% vs. 61%), and Shepparton (34% vs. 71%) had significantly reduced germination in complete darkness compared with an alternating 12-h light and 12-h dark photoperiod, whereas Midvale had consistent germination (91% vs. 99%). Temperatures between 17/7 C reduced germination for Maffra (42% vs. 73%), Tenterfield (34% vs. 55%), and Shepparton (33% vs. 59%) compared with the mean of all other temperature combinations, whereas Midvale had consistent germination. Furthermore, germination for all populations was consistent between pH 4 and 9. For salinity, germination was significantly reduced at ≥100 mM for Maffra (29% vs. 67%), ≥150 mM for Tenterfield (29% vs. 94%) and Shepparton (39.5% vs. 81.5%), and 250 mM for Midvale (39% vs. 82%) compared with the mean of all other concentrations. Although each trial was conducted independently, the data can be used to generate species-targeted management. Such strategies include maintaining high levels of quarantine and hygiene programs to avoid future spread; where practical, applying light-limiting strategies (mulching, tilling, or scraping) for the Maffra, Tenterfield, and Shepparton populations; and maintaining management efforts year-round, as the species can germinate under a wide range of conditions.
Effects of fertility amendments on weed growth and weed–crop competition: a review
Authors: Little Neith G. , DiTommaso Antonio , Westbrook Anna S. , Ketterings Quirine M. , Mohler Charles L.
Published: January 2021

Macronutrient inputs to annual cropping systems can benefit weeds as well as crops, sometimes decreasing or eliminating the benefits of fertilization. This interaction between fertility management and integrated weed management is becoming increasingly important as these fields increase their focus on efficiency and prevention, respectively. The risk of increased weed competition reflects the fact that weed biomass and height may be highly responsive to nitrogen, phosphorus, and/or potassium. This generalization is supported by monoculture studies of species such as redroot pigweed (Amaranthus retroflexusL.), common lambsquarters (Chenopodium albumL.), and barnyardgrass [Echinochloa crus-galli(L.) P. Beauv.] and by ecological theory. However, field studies indicate variation in the effects of macronutrients on weed–crop competition and crop yield, even within species groups. To address challenges in interpreting, comparing, and extrapolating from these diverse reports, we propose a conceptual framework that summarizes the mechanisms underlying observed variation within and between studies. This framework highlights functional traits and trends that help predict yield outcomes in binary weed–crop interactions. Important factors include timing of emergence, maximum heights of the weed and crop, and relative responsiveness to the added nutrient. We also survey recent work on the effects of nutrient source (e.g., the composition of organic amendments) on weed–crop competition. Because different sources vary in their nutrient release dynamics and supplied nutrient ratios, they may have dramatically different effects on weed–crop competition and crop yield. Finally, we offer a guide to best practices for studies of fertility effects on weed–crop competition. Although this review highlights several topics requiring further research, including fertility effects on multispecies interactions and interactions with other environmental factors, emerging methods offer considerable promise. Ultimately, an improved understanding of nutrient effects on weed–crop competition will contribute to the efficient and effective management of diverse cropping systems.
Newly Identified Instabilities Enhance Atmospheric Turbulence
Authors: Rehnberg Morgan
Published: January 2021

New high-resolution imaging and modeling reveal the first evidence of enhanced turbulence due to gravity wave modulation of Kelvin-Helmholtz instabilities.
Intranasal administration of α-synuclein preformed fibrils triggers microglial iron deposition in the substantia nigra of Macaca fascicularis
Authors: Guo Jian-Jun , Yue Feng , Song Dong-Yan , Bousset Luc , Liang Xin , Tang Jing , Yuan Lin , Li Wen , Melki Ronald , Tang Yong , Chan Piu , Guo Chuang , Li Jia-Yi
Published: January 2021

Iron deposition is present in main lesion areas in the brains of patients with Parkinson’s disease (PD) and an abnormal iron content may be associated with dopaminergic neuronal cytotoxicity and degeneration in the substantia nigra of the midbrain. However, the cause of iron deposition and its role in the pathological process of PD are unclear. In the present study, we investigated the effects of the nasal mucosal delivery of synthetic human α-synuclein (α-syn) preformed fibrils (PFFs) on the pathogenesis of PD in Macaca fascicularis. We detected that iron deposition was clearly increased in a time-dependent manner from 1 to 17 months in the substantia nigra and globus pallidus, highly contrasting to other brain regions after treatments with α-syn PFFs. At the cellular level, the iron deposits were specifically localized in microglia but not in dopaminergic neurons, nor in other types of glial cells in the substantia nigra, whereas the expression of transferrin (TF), TF receptor 1 (TFR1), TF receptor 2 (TFR2), and ferroportin (FPn) was increased in dopaminergic neurons. Furthermore, no clear dopaminergic neuron loss was observed in the substantia nigra, but with decreased immunoreactivity of tyrosine hydroxylase (TH) and appearance of axonal swelling in the putamen. The brain region-enriched and cell-type-dependent iron localizations indicate that the intranasal α-syn PFFs treatment-induced iron depositions in microglia in the substantia nigra may appear as an early cellular response that may initiate neuroinflammation in the dopaminergic system before cell death occurs. Our data suggest that the inhibition of iron deposition may be a potential approach for the early prevention and treatment of PD.