bluuebunny/crossref_metadata_2025 huggingface dataset:
Meningkatkan Motorik Kasar Melalui Permainan Pohon dan Tupai Pada Anak Sekolah Dasar Kelas 6
Authors: Rosid Muhidin  , Entan Saptani
Published: October 2024

Tujuan dari penelitian adalah untuk meningkatkan kemampuan motorik kasar melalui permainan pohon dan tupai pada anak sekolah dasar kelas VI, Jenis penelitian adalah Penelitian Tindakan Kelas (PTK). Instrumen yang digunakan berupa lembar observasi, jumlah sampel 20 anak dan data dianalisis dengan menggunakan rumus presentase. Hasil penelitian menunjukkan bahwa pada gambaran observasi aktivitas anak pada siklus I jumlah perolehan skor dengan katagori nilai sangat baik mendapatkan 4 orang dengan presentase 20%, 6 orang mendapatkan nilai baik dengan presentase 30%, 2 orang mendapatkan nilai sedang dengan presentase 10%, 1 orang mendapatkan nilai kurang dengan presentase 5%, dan 7 orang mendapatkan nilai sangat kurang dengan presentase 35%. Sedangkan Pada siklus ke II untuk katagori dengan nilai sangat baik menjadi 7 orang dengan presentase 35%, 3 orang mendapatkan nilai baik dengan presentase 15%, 2 orang mendapatkan nilai sedang dengan presentase 10%, 3 orang mendapatkan nilai kurang dengan presentase 15%, dan 5 orang mendapatkan nilai sangat kurang dengan presentase 25%. Berdasarkan data tersebut dapat disimpulkan bahwa permainan tradisional pohon dan tupai dapat meningkatkan kemampuan motorik kasar anak karena dalam permainan tersebut banyak melibatkan gerakan otot-otot besar.
Model Aktivitas Fisik Berbasis Outdoor Activity Untuk Kepemimpinan Anak Pra Remaja
Authors: Syukur Muhammad Ghifari , Hartman Nugraha
Published: October 2024

Kegiatan aktivitas fisik berbasis outdoor activity dengan membuat suatu program permainan yang memiliki indikator kepemimpinan di dalamnya. Program ini dibuat dalam bentuk aktivitas fisik dengan terdapat unsur permainan di dalam nya. Tujuan dari dibuatnya aktivitas fisik berbasis outdoor activity ialah untuk membuat kegiatan yang biasanya di lakukan di dalam kelas di lakukan di tempat yang berada di luar kelas, bertujuan agar siswa merasakan sensasi baru dalam melakukan kegiatan aktivitas fisik. Di samping itu kegiatan aktivitas fisik juga di tambah dengan indikator kepemimpinan agar anak belajar bagaimana berkerja sama dalam kelompok, mengelola emosi, pemecahan masalah dalam kelompok dan pengambilan keputusan. Selama ini aktivitas fisik dianggap membosankan dengan di adakannya aktivitas fisik berbasis outdoor activity di harapkan menjadi lebih bervariatif dan menarik, sehingga para anak pra remaja bisa mengikuti kegiatan dengan senang bahkan berpotensi membuat mereka menjadi lebih aktif serta rajin melakukan aktivitas. Menurut Dick et al. (2005) mengembangkan model-model pengembangan yaitu model ADDIE, model tersebut terdiri dari lima tahapan pengembangan. Model yang melibatkan tahap-tahap pengembangan model dengan lima langkah atau fase pengembangan meliputi: Analysis, Design, Development or Production, Implementation or Delivery and Evaluations. Hasil akhir dari produk model aktivitas fisik berbasis outdoor activity untuk kepemimpinan anak pra remaja setelah dilakukan penelitian dapat disimpulkan bahwa model permainan yang di terapkan layak dan sesuai. Hasil dari analisis kebutuhan menunjukan bahwa anak-anak sangat senang dan bersemangat mengikuti permainan yang berikan. Dengan menerapkan model aktivitas fisik berbasis outdoor activity untuk kepemimpinan anak pra remaja anak-anak akan lebih senang melakkan aktivitas fisik atau permainan di luar ruangan dan tidak hanya melakukan kegiatan di dalam kamar atau terpaku pada gadget seiring perkembangan zaman. Serta permainan aktivitas fisik ini juga memiliki indikator kepemimpinan, dimana di harapkan anak dapat mengimplementasikan indikator tersebut dalam kehidupan sehari-hari. Pembentukan kepemimpinan lewat aktivitas fisik di rasa sangat baik karena anak dapat melakukannya secara bersama-sama maupun individu dan melakukannya dengan gembira.
A hallott szöveg értését fejlesztő mozgásos gyakorlatok az anyanyelvi órán
Authors: Zsófia Gerák
Published: October 2024

A jelen tanulmány témája olyan középiskolások számára készített mozgásos gyakorlatok, amelyek a hallott szövegek értését fejlesztik. Az elméleti bevezető bemutatja az auditív ingerként feldolgozott szövegek értésének a folyamatát és a mozgásos feladatok csoportosítását. A gyakorlatok a beszédmegértés hierarchikus felépítésű modelljének a szintjeibe sorolhatók: beszédészlelést, beszédmegértést és értelmezést fejlesztő feladatok szerepelnek a tanulmányban. A szinteken belül különböző típusú mozgásos gyakorlatok olvashatók: családkereső, mozdulatkódos és élőképtípusú mozgásos feladatok. A feladatok könnyen beilleszthetők az anyanyelvi órákba, ugyanis anyanyelvi témaköröket dolgoznak fel. A bemutatott gyakorlatok a tanóra bármelyik szakaszában alkalmazhatók; így a ráhangoló, a jelentésteremtő és a reflexiós szakaszban is. A gyűjteményben szereplő feladatok könnyen módosíthatók, így különböző anyanyelvi témakörök feldolgozásakor is használhatók.
Investigation of optical properties of cadmium sulfide (CdS) thin films by chemical bath deposition.
Authors: Al-Jawad Selma M. H. , Mousa Ali M. , Taha Wessal Aead
Published: October 2024

في هذا البحث تم ترسيب الاغشية الرقيقة لكبريتيد الكادميوم على قواعد من الزجاج بأستعمال تقنية الترسيب بالحمام الكيميائي من محلول مائي لكبريتيد الكادميوم (CdS) والثايوريا. الاغشية المحضرة تمتاز بكونها منتظمة ،ذات التصاقية وتمتلك نفاذية عالية في المنطقة المرئية . الدراسة التي تمت لأغشية كبريتيد الكادميوم تتضمن النفاذية البصرية، الثابت البصري ،ثابت العزل الكهربائي ،التوصيلية الضوئية ،فجوة الطاقة . الاغشية التي تمت دراستها في هذا البحث لها نفاذية عالية تصل الى اكبر من 86% لأطوال موجية تتراوح بين (500نانومتر الى 900نانومتر) وفجوة الطاقة 2.4 الكترون فولت.
(σ,τ )– (J,R) – DERIVATIONS ON JORDAN IDEALS
Authors: Saed Ikram A.
Published: October 2024

لتكن R حلقة تجميعية مركزها Z(R). نتائج Bell  و Kappe المعروفة والمتعلقة بالمشتقات على الحلقات الاولية درست بتوسع من قبل العديد من الباحثين، بعض هؤلاء الباحثين عمموا هذه النتائج لمشتقة - a مثلYenigual و Arguc والبعض الاخر عمموا هذه النتائج لمشتقة - (σ,τ )– (J,R)  مثل M.Asharf.
            ان الهدف الرئيسي لهذا البحث هو دراسة تأثير المشتقة – (σ,τ )– (J,R)  والمشتقة من اليسار – (σ,τ )– (J,R)  على مثاليات جوردان.
Clinical Insights into Pediatric Foreign Bodies: A Cluster Analysis of Symptoms and Assessment of Caregiver Reports
Authors: Alzate-Ricaurte Sergio , Gallego Edgar Dario Alzate , Salazar Santiago Correa , Gómez Inés Elvira , Barbosa Mario Miguel , Avila Fernando Fierro
Published: October 2024

Foreign body (FB) events are prevalent in emergency room consultations, with 107,000 cases annually in the United States (80% in the pediatric population). They result in an estimated 1,500 mortalities each year. A cross-sectional study between February 2008 and September 2015, employing hierarchical cluster analysis of signs and symptoms at presentation to the emergency room was performed. Sensitivity, specificity, and decision curve analysis for a caregivers’ report of events was calculated with confirmed FB diagnosis as a reference. 1,032 patients were included, 886 suspected ingestion and 166 suspected aspiration patients. For aspiration, a higher frequency of complications (14.3%) and mortalities (4.76%) were observed in the cluster exhibiting most respiratory symptoms. For ingestion, associations for complications (3.6%), longer stays (mean, 55.1 hours) and mortality (n = 2) were identified in a cluster with respiratory pattern. Increased respiratory symptoms at presentation are potential predictors of severe outcomes, intuitively in cases of aspiration, but notably in ingestion. Although definitive diagnostic procedures are still necessary, the severity of respiratory symptoms helps identify patients at risk of complications and helps prioritize resources when necessary. Caregivers’ certainty of FB aspiration yielded a 72.5% sensitivity and 45.4% specificity. Certainty of FB ingestion resulted in 86.8% sensitivity and 19.8% specificity.
Pollution and health risk assessment of soil, water and vegetables from an ion-adsorption rare earth mining area in Ganzhou, China
Authors: Zhu Liye , Huang Jinyu , Hu GongHua , Wang Qi , Huang Hui , Wang Sihui , Wu Chunmei , Sun Ziyue , Fang Yi , Hao Ming , Xiong Liang
Published: October 2024

Rare earth elements (REEs) are increasingly recognized as significant environmental pollutants due to their environmental persistence, bioaccumulation, and chronic toxicity. This study assessed REEs pollution in soil, water, and vegetables in an ion-adsorption rare earth mining area in Ganzhou, and evaluated the associated health risks to the local population. Results indicated that the REEs content in soil ranged from 168.58 to 1915.68 mg/kg, with an average of 546.71 mg/kg, substantially surpassing the background level for Jiangxi Province (243.4 mg/kg) and the national average (197.3 mg/kg). Vegetables displayed an average REE content of 23.17 mg/kg in fresh weight, far exceeding the hygiene standard of 0.7 mg/kg. Water samples contained REEs at a concentration of 4.09 µg/L. The estimated daily intake (EDI) of REEs from vegetables exceeded the threshold for subclinical damage, posing potential health risks, particularly for children and adolescents. Further analysis of the adjusted average daily intake (ADI) suggested that while most vegetable consumption remains within safe threshold, the intake of REEs from high-risk vegetables such as pakchoi and radish should be limited.
Predictive Value of Perilesional Edema Volume in Melanoma Brain Metastasis Response to Stereotactic Radiosurgery
Authors: Yavorska Mariya , Tomiciello Miriam , Antonio Sciurti , Cinelli Elisa , Rubino Giovanni , Perrella Armando , Cerase Alfonso , Pastina Pierpaolo , Gravina Giovanni Luca , Arcieri Silvia , Mazzei Maria Antonietta , Migliara Giuseppe , Baccolini Valentina , Marampon Francesco , Minniti Giuseppe , Tini Paolo
Published: October 2024

Background and aim:
Stereotactic radiotherapy (SRT) is an established treatment for melanoma brain metastases (MBM). Recent evidence suggests that perilesional edema volume (PEV) might compromise the delivery and efficacy of radiotherapy to treat BM. This study investigated the association between SRT efficacy and PEV extent in MBM.
Materials and Methods
This retrospective study reviewed medical records from January 2020 to September 2023. Patients with up to 5 measurable MBMs, intracranial disease per RANO/iRANO criteria, and on low-dose corticosteroids were included. MRI scans assessed baseline neuroimaging, with PEV analyzed using 3D Slicer. SRT plans were based on MRI-CT fusion, delivering 18–32.5 Gy in 1–5 fractions. Outcomes included intracranial objective response rate (iORR) and survival measures (L-iPFS and OS). Statistical analysis involved decision tree analysis and multivariable logistic regression, adjusting for clinical and treatment variables.
Results
Seventy-two patients with 101 MBM were analyzed, with a mean age of 68.83 years. The iORR was 61.4%, with Complet Response (CR) in 21.8% and Partial Response (PR) in 39.6% of treated lesions. PEV correlated with KPS, BRAF status, and treatment response. Decision tree analysis identified a PEV cutoff at 0.5 cc, with lower PEVs predicting better responses (AUC = 0.82).Patients with PEV ≥ 0.5 cc had lower response rates (iORR 44.7% vs. 63.8%, p < 0.001). Median OS was 9.4 months, with L-iPFS of 27 months. PEV significantly impacted survival outcomes.
Conclusions
A more extensive PEV was associated with a less favorable outcome to SRT in MBM.
Bedside tool for the diagnosis of gastric mucosal lesions prior to endoscopy
Authors: Kayamba Violet , Munshi Husna , Mulenga Chola , Kelly Paul
Published: October 2024

Objective
Diagnosis of upper gastrointestinal (UGI) mucosal lesions is primarily via endoscopy. We investigated the diagnostic accuarcy of the Sanguis-filum (S-filum), a bedside tool for detecting UGI mucosal lesions.
Results
We tested 200 consenting patients, 112 (56%) females and 88 (44%) males attending for endoscopy at the University Teaching Hospital, Lusaka. Ninety-five (47%) of the patients had visible mucosal lesions; 45 (23%) of them had peptic ulceration, and 9 (5%) had gastric cancer. Ninety-one (46%) S-filum tests were positive. We found an association between positive S-filum results and the presence of mucosal lesions (OR 2.2; 95% CI 1.2–4.1, p = 0.007) but not gastric cancer (OR 3.5; 95% CI 0.7–22, p = 0.09). S-filum was insufficiently sensitive; missing mucosal lesions in 54%, and gastric cancer in 33% of cases. For detection of mucosal lesions, the sensitivity was 56%, specificity 64% with an area under the receiver operating characteristic (ROC) curve of 0.60. For GC, the sensitivity was 67%, the specificity was 64%, with area under the ROC of 0.65. As a screening test prior to endoscopy, the S-filum is not sufficiently accurate for detecting UGI mucosal lesions of GC.
A Comprehensive analysis of the prognostic value, expression characteristics and immune correlation of MKI67 in cancers
Authors: pan xiaolan , Wei Caibiao , Su Jingyu , Fang Min , Lin Qiumei , Qin Yuling , Gao Jie , Zhao Jie , Zhao Huiliu , Liu Fengfei
Published: October 2024

Background: nuclear-associated antigen Ki67 (Ki67) emerges as a clinically practical biomarker for proliferation assessment among many cancer types. However, the definite prognostic value of Ki67 against a specific cancer type has remained vague. This study aims to perform a comprehensive pan-cancer analysis of the prognosis value of Ki67 across various cancer types.
Methods: This study explored the expression, prognostic value, and tumor-infiltrating immune of MKI67 in the TCGA database by pan-cancer, and then performed immunohistochemical, correlation analysis and prognostic analysis using 10028 patients of the top 10 cancer patients in China we collected. The correlation between MKI67 expression and survival outcome, clinical features, MSI, TMB, and tumor-infiltrating immune cells by TCGA database, xCell, and TIMER algorithms.
Results: MKI67 expression was significantly upregulated across varied cancer types verified by datasets. We found MKI67 expression was significantly associated with poor prognosis in LUADLUSC, LIHC, and BRCA patients, but good prognosis in COADREAD and READ patients via Kaplan-Meier survival analysis using 10028 patients collected. These results of our validation were generally consistent with TCGA database except BRCA, COADREAD and READ. Meanwhile, upregulation of MKI67 elevates the degree of immune infiltration of several immune cell subtypes, such as functional T cells, CD4+ T cells, and CD8+ T cells, as well as, MKI67 was related to Cell cycle, Oocyte meiosis, p53 and other pathways.
Conclusion: Our comprehensive analysis may supply useful guidance on MKI67 applicability across various cancer types. These observed results contribute to the promise of MKI67 in a realistic clinical setting and improve the outcomes of cancer patients.
Survival machine learning model of T1 colorectal postoperative recurrence after endoscopic resection and surgical operation：a retrospective cohort study
Authors: Li Zhihong , Aihemaiti Yiliyaer , Yang Qianqian , Ahemai Yiliminuer , Li Zimei , Du Qianqian , Wang Yan , Zhang Hanxiang , Cai Yingbin
Published: October 2024

Objective
To construct a postoperative recurrence prediction model for patients with T1 colorectal cancer after endoscopic resection and surgical operation used survival machine learning algorithms.
Methods
Based on Two tertiary first-class affiliated hospitals, the case data of 582 patients with T1 colorectal cancer after endoscopic resection and surgical operation were obtained, and the information included patient personal information, treatment modalities, pathologically relevant information were extracted. After Boruta algorithm feature selection, Predictors of significant contributions were determined. The patients were divided into training set and test set at a ratio of 7༚3, five survival machine learning models: Random Survival Forest (RSF), GradientBoosting (GB), Survival Tree (ST), CoxPH and Coxnet for develop models.To interpret results based on SHAP algorithm.
Results
People at high risk of lymph node metastasis have a poorer prognosis, Different treatment methods have no significant impact on the prognosis of recurrence, The C-index and IBS scores of Random survival forest model in the test data are 0.848, 0.098, Its time-dependent AUC is 0.918, The interpretability analysis of the model showed that submucosal invasion depth < 1000µm, tumor budding grade BD1, Lymphovascular invasion and Perineural invasion is absent, well differentiated cancer cells, and tumor size < 20mm have positive effects on the model, Feature with negative gain is a contributing factor to the absence of recurrence in patients.
Conclusions
The prognostic model constructed by survival machine learning for patients with colorectal cancer has good performance. It can provide accurate individualized prediction.
Adverse events after nivolumab and ipilimumab combined immunotherapy in advanced renal cell carcinoma: a multicentre experience in Poland
Authors: Pacholczak-Madej Renata , Drobniak Artur , Stokłosa Łukasz , Bidas Anna , Dobrzańska Jolanta , Grela-Wojewoda Aleksandra , Roman Agnieszka , Tusień-Małecka Daria , Walocha Jerzy , Blecharz Paweł , Puskulluoglu Mirosława
Published: October 2024

Background: Immune checkpoint inhibitors (ICIs) have been employed in the adjuvant and metastatic setting of renal cell carcinoma (RCC) treatment. Among ICIs, combined immunotherapy has the highest risk for immune-related adverse events (irAEs). We aimed to document the incidence of irAEs in RCC patients treated with nivolumab and ipilimumab (O+Y), as data from the European population remain limited.
Materials and methods: We analysed data from 88 RCC patients treated with O+Y between May 2022 and June 2024 across six high-volume oncology units in Poland. We reviewed irAEs and estimated their impact on survival parameters via univariate and multivariate Cox proportional hazards regression models, along with log-rank tests.
Results: With a median follow-up of 11.3 months, the median overall survival (OS) was not reached, whereasthe median progression-free survival (PFS) was 12.8 months (6.3–19.3). A total of 74 irAEs were recorded in 50 patients. The most frequent events were endocrine (n=20, 27%), hepatic (n=15, 17%), general (n=12, 13.6%), and cutaneous (n=11, 12.5%). The occurrence of irAEs was associated with a 60% lower risk of disease progression (hazard ratio 0.44, 95% confidence interval 0.2–0.87, p=0.018) without impacting OS and higher disease control rate (n=45, 90% vs. n=24, 63.2%, p=0.004). In contrast, patients with hepatotoxicity had poorer outcomes, with a 2.6-fold greaterrisk of death (p=0.05).
Conclusions: IrAEs may serve as a predictive factor for the efficacy of the O+Y regimen in RCC patients. Special attention is needed for hepatotoxicity, as it can significantly impact survival outcomes.
First-trimester screening and small for gestational age in twin pregnancies: a single center cohort study.
Authors: Queirós Alexandra Sofia , Bernardo Ana , Rijo Cláudia , Carocha Ana , Ferreira Leonor , Martins Ana Teresa , Cohen Álvaro , Alves Marta , Papoila Ana Luísa , Simões Teresinha
Published: October 2024

Objective: This study aimed to investigate the association between maternal factors and first-trimester biophysical and biochemical markers with small for gestational age (SGA) neonates in twin pregnancies (TwPs).
Methods: Single center retrospective cohort study of TwPs followed from January 2010 to December 2022 at a tertiary perinatal center, Lisbon, Portugal. Inclusion criteria consisted of 572 TwPs. Maternal and pregnancy characteristics, mean arterial pressure, pregnancy-associated plasma protein-A (PAPP-A), β-human chorionic gonadotropin (β-HCG), and uterine artery pulsatility index (UtA-PI) were analyzed. Univariable, multivariable logistic regression (LR) and receiver-operating characteristic curve analyses were performed. The main outcomes measures considered were: SGA <3rd, <5th and <10th percentile, composite outcome of SGA concurrent with preterm birth (PTB) (<32, <34, and <36 weeks).
Results: TwPs affected with SGA <3rd, <5th or <10th percentiles were 120/572 (20.9%), 157/572 (27.4%) and 190/572 (33.2%), respectively. SGA <3rd percentile was associated with higher rate of PTB, 59.0% of cases <32 weeks, OR 6.4 (95%CI: 3.2-12.7, p<0.001). UtA-PI and PAPP-A were identified as significant independent risk factors associated with SGA, as well as with the composite outcome of SGA concurrent with PTB. A LR model was obtained for the composite outcome SGA <3rd percentile and PTB <32 weeks, with an AUC of 0.765, a sensitivity rate of 70%, and a false positive rate of 20%.
Conclusion: SGA concurrent with prematurity significantly impacts TwPs, and the majority of pregnancies at risk for this outcome can be detected in the first trimester. However, larger datasets are necessary to develop robust predictive models.
Synopsis:
The association between first-trimester screening data and SGA concurrent with very preterm birth in twin pregnancies was determined in most of the cases.
High-resolution climate models improve simulation of monsoon rainfall changes in the Ganga-Brahmaputra-Meghna basin
Authors: Ali Haider , Fowler Hayley J , Turner Andrew G
Published: October 2024

This study examines observed and projected changes in monsoon timing (onset/withdrawal/duration) and strength (total and extreme rainfall) in the Ganges-Brahmaputra-Meghna basin. While prior South Asia monsoon research has mainly used coarse-resolution models, we utilised CMIP6 HighResMIP models to assess whether improved horizontal resolution (HR-models: <0.25°) improves the simulation of the monsoon when compared to low resolution (LR-models: 0.35 to 1.2 °), evaluated against reference datasets (MSWEP and ERA5). Our findings indicate that HR-models generally outperform LR-models in capturing monsoon characteristics, with the bias in annual average rainfall higher in LR-models. Between 1979-2014, MSWEP (ERA5) tends towards an earlier (later) onset by around 7 (3) days, a later withdrawal by around 8 (12) days, resulting in a longer monsoon duration of approximately 15 (9) days, respectively; much larger changes than both HR- and LR- MODELS. The trends in duration are highest for MSWEP and lowest for LR-models. We find that HR-models better capture observed trends in total and extreme rainfall over 1979-2014 compared to LR-models. For the future climate (2015-2050), HR-(LR-) model ensembles project a delay of ~4 (3) days in monsoon onset under the SSP585 forcing scenario, with HR-models indicating a later onset compared to LR-models. However, HR-models project a shorter monsoon duration and an earlier withdrawal (~3 days) compared to LR-models. We find that HR-models project a significantly greater increase in rainfall than LR-models: these project increases in extreme monsoon rainfall (up to 5.55%/decade) and total monsoon rainfall (around 1.4%/decade) in the GBM basin, while LR-models project little change. Our findings highlight the large uncertainties in simulating monsoon characteristics from climate models, but show that HR-models can be helpful in studying changing monsoon dynamics over the complex topography of the GBM basin.
Remnant cholesterol has a nonlinear association with non-alcoholic fatty liver disease: A secondary retrospective cohort study in non-obese Chinese adults
Authors: Zhou Yan , Han Yong , Shu Qing
Published: October 2024

Objective
Evidence linking non-obese non-alcoholic fatty liver disease (NAFLD) with residual cholesterol (RC) is weak. In this study, Chinese adults who were not obese were examined for a relationship between NAFLD and RC levels.
Methods
16,004 non-obese volunteers were included in a retrospective cohort study at a Chinese clinic between the start of 2010 and the end of 2014. The correlation between initial RC levels and the likelihood of developing NAFLD was investigated using the proportional hazards regression (Cox) model. Using cubic spline functions and smooth curve fitting technique, a two-piecewise proportional hazards regression (Cox) method was used to investigate nonlinear associations between RC and NAFLD. There were numerous sensitivity assessments carried out. The information was posted on the DATADRYAD website.
Results
The results showed a positive correlation between RC and incidence of NAFLD after controlling for variables (HR = 1.061, 95% CI 1.045–1.078). Between RC and NAFLD, a nonlinear connection was found, with a turning point at 98.29 mg/dL. The effect sizes (HR) were 1.150 (95% CI 1.106, 1.194) and 1.009 (95% CI 0.982, 1.037) on either side of the turning point, respectively. A sensitivity examination further supported the stability of the findings.
Conclusion
In a Chinese sample that is not obese, this research emphasizes a potentially favorable nonlinear connection between RC and NAFLD risk. When RC was below 98.29 mg/dL, RC was substantially associated with the risk of NAFLD. Thus, from a therapeutic standpoint, keeping RC levels below this cutoff would be advantageous.
Simulation and test of the seeding performance of clamped dibbler based on ADAMS-EDEM coupling
Authors: Mao Zibin , Ma Jinhu , Xu Luochuan , Li Xiyang , Li Junwei , Hu Bin
Published: October 2024

To address the problems of poor adaptability and low working speed of the current mechanical dibblers for irregular seeds, such as maize seeds, a springless clamping and variable hole volume seed-taking method was proposed. Select large, medium, and small maize seeds to study the effects of operating speed and seed morphology on seeding performance, and the Adams-Edem coupling simulation was used to perform a virtual test of the sowing performance. Two equilibrium states of seeds during abnormal seed-taking were revealed, and a method to break the equilibrium state utilizing the movement law of the seed-taking slider was put forward. Through the analyse of shape adaptability, it was found that the mean length of the toothed seed and the coincidence position of the width at the shaped hole's entrance under different thicknesses greatly influenced the seeding performance. When the rotation speed was 85 rpm (5.8 km·h− 1), the qualified index of the four seeds was greater than 92.5%, the repetition index was less than 5%, and the coefficient of seed distance variation was less than 15%. The dibbler satisfies the agronomic requirement of precision seeding for each variety and provides a new method for the mechanical sowing of irregularly shaped seeds.
Comparison of the aquatic toxicity of diquat and its metabolites to zebrafish Danio rerio
Authors: Shi Lanxin , Wang Xinru , Dai Yaoyao , Zhou Wendong , Wu Shenggan , Shao Bo , Nabanoga Gorettie Nsubuga , Ji Chenyang , Zhao Meirong
Published: October 2024

Diquat (DQ) is a non-selective, fast-acting herbicide that is extensively used in aquatic systems. DQ has been registered as the substitute for paraquat due to its lower toxicity. However, the widespread presence of DQ in aquatic systems can pose an ecological burden on aquatic organisms. Additionally, DQ can degrade into its metabolites, diquat-monopyridone (DQ-M) and diquat-dipyridone (DQ-D) in the environment, whereas, the ecological risks of the metabolites remain uncertain. Herein, the aquatic ecological risks of DQ and its metabolites were compared using zebrafish as model non-target organism. Results indicated that DQ and its metabolites did not induce significant acute toxicity to zebrafish embryos at environmental relevant levels. However, exposure to DQ and DQ-D resulted in oxidative stress in zebrafish embryos. DQ treatment led to increased levels of reactive oxygen species (ROS), malonaldehyde (MDA), and glutathione (GSH) in the embryos, while DQ-D enhanced internal MDA and GSH levels. Moreover, the activities of the antioxidative enzymes, superoxide dismutase (SOD) and catalase (CAT), were significantly suppressed by DQ and DQ-D. Besides, the expression levels of antioxidative-related genes (Mn-SOD, CAT, and GPX) were disturbed accordingly after DQ and DQ-D treatments. These findings underscore the importance of a more comprehensive understanding of the ecological risks associated with pesticide substitutions and pesticide metabolites. Such knowledge is crucial for significant improvements in pesticide regulation and policy-making in the future.
Evaluating the Probiotic Potential of Lactic Acid Bacteria Isolated from Nipponia nippon Feces
Authors: Yang Lei , luo Jie , Zeng Yan , Zhang Baoyue , Wang Yang , Zhao Xiaoling , Lin Juchun , Li Haohuan , Xu Funeng , Zhang Wei , Fu Hualing , Amevor Felix Kwame , Liu Rui , Shu Gang
Published: October 2024

This study aims to identify an optimal lactic acid bacterial strain from the feces of healthy Nipponia nippon. From the fecal samples, twenty isolates were obtained. The isolates were subjected to biochemical identification, acid and bile tolerance tests, in vitro inhibition of pathogenic bacteria assays, cell surface hydrophobicity assessment, antibiotic susceptibility test, and hemolytic activity evaluation to determine their probiotic potential. The results indicated that six isolates (D1, D2, D6, E7, D8, D9) could survive in low acid and high bile salt conditions. Except for D8, all six isolates exhibited inhibitory activity against tested pathogens. Isolates D6 and E7 showed the least resistance to antibiotics, and only E7 demonstrated moderate hydrophobicity. The E7 strain was further studied in depth and identified as L. plantarum through 16srRNA sequencing. To assess its safety, mice were fed with the E7 strain, and the results showed no deaths or adverse effects on blood cellular components. Whole genome sequencing of Lactobacillus plantarum E7 using Nanopore PromrthION48 and the Illumina Novaseq revealed a ring chromosome and two ring plasmids. The chromosome encodes 3024 genes, some associated with cell adhesion, acid and bile salt tolerance, antioxidant enzymes, and secondary metabolites. Plasmids contained fewer coding genes. The VFDB database detected only a few virulence genes related to adherence, stress survival, exoenzyme production, immune modulation, and regulation factors. KEGG database analysis indicated that the genes of this bacterium are primarily involved in carbohydrate metabolism, amino acid metabolism, vitamin and cofactor metabolism, environmental information processing and genetic processing. This study lays a theoretical foundation for the clinical application and development of probiotics.
Alleviation of Myocardial Infarction by Hydrogen Sulfide-Releasing Nanoparticles: Mechanisms and Therapeutic Effects
Authors: Zhan Yujia , Zhao Xueshan , Bi Siwei , Liu Ruiqi , Ge Yuxuan , Gu Jun , Wang Yin
Published: October 2024

Myocardial infarction (MI), a common and severe disease threatening human health worldwide, results from ischemic and hypoxic-induced necrosis of cardiac tissue due to coronary artery obstruction or rupture. Hydrogen sulfide (H2S) is a gasotransmitter involved in various physiological and pathological processes. Exogenous supplementation of H2S is significantly beneficial for the treatment of MI. In this study, a novel H2S donor - zinc sulfide nanoparticles encapsulated in hyaluronic acid (HA@ZnS NPs), has been developed through a biomimetic mineralization process for the treatment of MI. HA@ZnS NPs can stably release H2S at the site of myocardial ischemic injury due to the acidic microenvironment. Compared to the MI group, the NP-treated group significantly improved cardiac function, including increased left ventricular ejection fraction and fractional shortening, as well as reduced end-systolic volume. Furthermore, the NPs significantly reduced the size of the myocardial infarction area, improved left ventricular remodeling, and exerted therapeutic effects by promoting angiogenesis and reducing apoptosis in cardiac tissue. In conclusion, HA@ZnS NPs demonstrate potential for treating MI through precise control of H2S release, providing valuable insights into new therapies for MI and laying the groundwork for the clinical application of H2S-releasing materials in the future.
Deep insight: An Efficient Hybrid Model for Oil Well Production Forecasting Using Spatio-Temporal Convolutional Networks and Kolmogorov-Arnold Networks
Authors: Hu Yandong , Xin Xiankang , Yu Gaoming , Deng Wu
Published: October 2024

As global energy demand continues to grow, the oil and gas industry faces increasing pressure to optimize production and achieve sustainability. Accurate prediction of oil well production is essential for effective resource management and operational efficiency. However, traditional mathematical methods struggle with the complex nonlinear characteristics of production data, and while hybrid neural networks have shown promise, they often lack sensitivity to changes in production conditions and suffer from limited generalization due to their complex architectures and numerous parameters. To overcome these limitations, this study introduces a novel hybrid model that integrates Temporal Convolutional Networks (TCN) with Kolmogorov-Arnold Networks (KAN), optimized by Whale Optimization Algorithm (WOA). This approach significantly reduces parameter complexity while enhancing global optimization, resulting in improved model robustness and adaptability. TCN excels in capturing the spatio-temporal dynamics of fluid and reservoir properties, while KAN, with its strong nonlinear approximation capabilities, efficiently approximates functions with minimal hyperparameter tuning. Experiments conducted using data from the Volvo oil field (2008-2016) demonstrate that the WOA-TCN-KAN model outperforms other hybrid models in global search, spatio-temporal feature extraction, and nonlinear approximation, offering superior predictive accuracy and robustness in complex oil well production scenarios. This model provides strong support for improving operational efficiency in oil and gas reservoir development.
A comparative encapsulation behaviour analysis and biological studies of C- alkyl calix[4]resorcinarenes-4-hydroxybenzoic acid inclusion complexes
Authors: Kasi Sathiyaseelan , Albert Antony Muthu Prabhu
Published: October 2024

In this work, we are reported the comparative encapsulation behaviour analysis and biological applications of C-alkyl calix[4]resorcinarenes:4-hydroxybenzoic acid (C4RAs-4HBA) inclusion complexes. The solvent evaporation method was applied to prepare the solid C4RAs-4HBA (5a-5d) inclusion complexes. Phase solubility analysis and jobs plot method was used to identify the stoichiometric binding ratio, stability constant (K), complexation efficiency (CE) and type of phase solubility diagram formed between the aqueous solution of C4RAs (3a-3d) and 4HBA (compound 4). From the results of UV-Visible, fluorescence, 1H-NMR, 13C-NMR, PXRD and SEM imaging analysis was confirmed by formation of 1:1 ratio of C4RAs-4HBA inclusion complexes between C4RAs (3a-3d) and 4HBA (compound 4). In gas phase DFT/B3LYP 3-21G method of molecular modeling studies were applied to identify the more stable and reactive binding orientation (A or B) from the values of band gap energy, energy and complexation energy values. A redox a reaction of phosphomolybdate assay was used to find out the informations of total antioxidant capacity (TAC), % total antioxidant capacity (% TAC) and IC50 values. Kirby-Bauer antibacterial activity and Disc diffusion antifungal activity of C4RAs, 4HBA and their inclusion complexes were compared with the standard antibacterial (amikacin) and antifungal (nystain) drugs.
Physical and Social Health Needs of Postoperative Bariatric Surgery Patients: A Focus Group.
Authors: Glauser Angela C. , PT Robin L. Marcus , McGarrity Larissa A. , PT Anne Thackeray , Volckmann Eric T. , Terrill Alexandra L.
Published: October 2024

Purpose
This qualitative study explored the health needs of patients after undergoing bariatric surgery. The study specifically aimed to describe the unique physical, emotional, and social challenges patients face following surgery in order to inform the development of future obesity treatment programs.
Methods
A ninety-minute focus group was conducted using a semi-structured interview guide. Bariatric surgery patients were enrolled using purposive sampling. The mean number of months since surgery was 20.2 (SD 10.8). The mean age of participants was 53.3 (SD 9.8) years. The focus group was both audio and video recorded, transcribed, and analyzed using topic and analytical coding.
Results
Three main themes emerged revealing postoperative needs for 1) assistance with physical changes and reduced barriers to exercise, 2) reinforcement for healthy eating behaviors, and 3) emotional support from peers, family, and community.
Conclusions
Findings suggest that rehabilitation following bariatric surgery is complex in nature and patients may benefit from both pre- and post-surgery programs that address their unique needs. Weight maintenance and sustaining healthy behavior change post-surgery requires ongoing personal and professional assistance. Interventions should emphasize healthy eating practices, include practical exercise suggestions, and offer social and emotional support.
Research and Implementation of an Authentication System Fusing Physical Layer and Behavioural Fingerprinting for Power Systems
Authors: Chen Mu , Li Nige , Li Yong , Zhang Bo , Xiao Yongcai , Wang Tengyan , Lu Ziang
Published: October 2024

With the rapid growth of resource integration in modern power systems, these resources are diverse, large-scale, and situated in complex and open physical environments, making them relatively vulnerable to cyber-attacks due to weaker security measures. To address this challenge, this paper proposes an identity authentication architecture system that integrates software and hardware. In the software fingerprint section, we extract packet characteristics and statistical features through network probing, and combine them with time difference sequence features obtained from side-channel monitoring to generate the software fingerprint of the power smart terminal by direct concatenation. This method incorporates various characteristic information, enhancing the recognition accuracy of the fingerprint features. In the hardware fingerprint section, we generate hardware fingerprints by extracting the preamble signal and performing statistical feature analysis. Finally, using an ensemble learning method, we integrate the software and hardware fingerprints to generate device fingerprint features. This approach effectively addresses the security authentication issue of power equipment based on High-Level Power Line Communication (HPLC), achieving a recognition rate of over 95% under most machine learning classification methods.
Predicting software defects: a comprehensive analysis of machine learning approaches
Authors: Sistaninezhad Masoud , Rajebi Saman , Pouramirarsalani Shahrzad , Pakzad Sajjad , Asadi Houshyar , Pedrammehr Siamak
Published: October 2024

In software development, achieving flawless software is essential for maintaining quality and reducing testing costs. Predicting software defects is a crucial aspect of enhancing software quality. This paper explores various techniques, including feature selection, principal component analysis, and fisher discriminant ratio, utilizing well-known machine learning algorithms on the publicly available JM1 dataset, addressing the gap in the current literature. support vector machine, multi-layer perceptron, K-nearest neighbor, Naïve Bayes, and decision tree algorithms are utilized along with the K-Fold approach for class label classification. Additionally, a binary genetic algorithm with a support vector machine classifier is employed for feature selection, and a particle swarm optimization algorithm is used to determine optimal fisher discriminant ratio coefficients. Model performance is evaluated according to accuracy, sensitivity, specificity, F-measure, precision, and a confusion matrix. The findings indicate that all machine learning models perform well with different processing techniques. However, the support vector machine algorithm, when combined with optimal fisher discriminant ratio coefficients, achieved the highest accuracy at 88.2% and excelled in specificity at 99.6%. The K-nearest neighbor classifier with selected features attained the highest scores in precision, sensitivity, and F-measure. Other classification algorithms did not surpass these models in any performance metrics.
Mapping Seismic Vulnerability index on Durban using the spectral ratio Local site effects using Ambient noise Measurements for Durban
Authors: Manzunzu Brassnavy , Midzi Vunganai , Zulu Brian , Mulabisana Thifhelimbilu , Pule Tebogo
Published: October 2024

Ambient noise vibrations are widely used in the field of geotechnical earthquake engineering for site response analysis. Though generally weak, these vibrations are available anywhere and anytime and are an ideal source of energy for conducting seismic surveys. The use of horizontal to vertical spectral ratio (H/V) from ambient noise records, to characterise local site effects is now an established technique. This technique can be applied to estimate predominant frequencies, amplitude ratios and seismic vulnerability index of an area. Ninety sites were selected in Durban (KwaZulu-Natal Province) for ambient vibration measurements and H/V analysis. The analysis of recorded waveforms resulted in the determination of predominant frequencies as well as the amplitude ratios that can be assumed to be equivalent to amplification factors, allowing the city to be divided into zones of differing site effects. The results showed predominant frequencies ranging between 0.78 and 36.8 Hz and peak amplitude ratios in the interval 1.3 to 30.0. The predominant frequency and amplitude ratio results were then used to estimate a seismic vulnerability index, which was observed to vary from 0.2 to 87.3. The city was then successfully divided into three zones according to the obtained vulnerability index values. High vulnerability index values were found to correlate with coastal areas, thus indicating areas that are likely to suffer significant amplification of earthquake ground motion. These coastal areas are associated with thick sediments and alluvial plains, conditions which have been shown in many studies to have a significant impact on ground motion resulting in amplification. Building structures with natural frequencies close to the site predominant frequencies in these areas will experience large resonance effects. This study can be considered as a first step towards the microzonation of the city of Durban.
Rapeseed Protein Isolate in High-Fat Diet-Induced Obesity Reduction: A Study on Amino Acids and Their Biological Effects
Authors: Xu Feiran , Tang Juan , Ji Tong , Wang Yu , Tao Xuan , Xiong Zheng , Zhang Bao , Wang Zhigao
Published: October 2024

Current pharmacological treatments have not been effective in achieving sustainable and long-term weight loss. Studies have shown that reducing dietary fat alone is not sufficient to prevent weight gain and obesity. Proteins are used to change diet and cause weight loss. Rapeseed plant protein is a high-quality protein, and RPI provides all essential amino acids needed for proper nutrition. However, the suitability of RPI as a dietary protein source for weight loss and its potential effects on plasma amino acid levels in lower floating cells and the induction of satiety in lower floating cells remains unknown. Therefore, we analyzed the amino acid composition of rapeseed protein isolate (RPI) and evaluated its effect on high-fat diet-induced obesity using in vivo and in vitro models. The RPI group exhibited elevated levels of anti-obesity amino acids in the plasma compared to the CS and SPI groups, leading to reduced food intake, weight gain, Lee index, white adipose tissue weight, improved serum lipid profiles, and beneficial alterations in the intestinal microbiota of obese rats. Molecular analyses elucidated RPI’s role in metabolic signaling, revealing its activation of Mammalian Target of Rapamycin/p70S6K (mTOR/p70S6K) pathway, inhibition of AMP-activated protein kinase (AMPK) and Acetyl-CoA carboxylase (ACC) phosphorylation, and modulation of the melanocortin system by increasing α-Melanocyte-Stimulating Hormone (α-MSH) and Melanocortin 4 Receptor (MC4R) levels in paraventricular nucleus neurons. These findings suggest that RPI could potentially reduce obesity through amino acid-mediated inhibition, appetite suppression, and increased metabolism.
Development and validation of a novel endoplasmic reticulum stress-related lncRNA signature in laryngeal squamous cell carcinoma
Authors: Pan Xiazhi , Liu Duanshali , Xie Yingli , Li Beicheng , Zhang Shanshan , Li Gege , Li Xiaohan , Zheng Qiuchen , Zhao Kai , Liu Mingbo
Published: October 2024

Background Endoplasmic reticulum stress (ERS) is an intracellular process in which improperly folded proteins lead to a cellular stress response. Such responses serve to protect cells from damage and are tightly bound to the development and advancement of various tumors. How endoplasmic reticulum stress contributes to the onset and progression of laryngeal squamous cell carcinoma remains unclear. Our research aimed to find an ERS signature to forecast the prognosis of laryngeal squamous cell carcinoma and to investigate its potential biological functions.
Method LSCC sample data obtained from The Cancer Genome Atlas (TCGA) database were co-expressed with ERS- related genes, and then a prognostic signature on the basis of endoplasmic reticulum stress- related lncRNAs (ERS-related lncRNAs) was constructed by differential analysis and Cox regression analysis. Survival analysis, TMB, consensus cluster analysis, drug sensitivity analysis, immune analysis and clinical drug prediction were carried out on the model. Finally, the function of LHX1-DT was verified by in vitro experiments.
Results From the TCGA-LSCC cohort, 35 significantly different ERS-related lncRNAs were identified. Then, a prognostic signature consisting of three lncRNAs (AC110611.2, LHX1-DT, and AL157373.2) was identified. Kaplan-Meier analysis demonstrated the predictive ability of the model for overall survival. Calibration curves and receiver operating characteristic curves were validated and showed high predictive accuracy. Ultimately, the experimental results verified the expression of LHX1-DT in LSCC.
Conclusion Our work built an ERS-related risk signature, providing a useful exegesis for LSCC prognosis prediction.
A Case Report of Acute Fatty Liver of Pregnancy
Authors: Liao Wei , Luo Qian , Wang LiFei , Liu RuiQian
Published: October 2024

Objective: Report on a rare pregnancy complication.
Background: Acute fatty liver of pregnancy (AFLP) is one of the most common causes of acute liver failure during pregnancy, although its incidence is low. The primary pathological change is diffuse microvesicular steatosis of hepatocytes. The manifestations of AFLP are nonspecific, and its diagnosis typically relies on clinical symptoms, laboratory findings, and the Swansea criteria as an auxiliary diagnostic tool. Early diagnosis and timely termination of pregnancy are crucial measures to improve outcomes.
Case Description: A 23-year-old woman, at 38+5 weeks of gestation, G1P0, presented with a 10-day history of abdominal distension, nausea, vomiting, and constipation, with only the ability to consume small amounts of liquid food. The patient reported a long-term preference for carbonated beverages and an aversion to drinking plain water. Upon admission, physical examination revealed severe jaundice of the skin and sclera. Laboratory tests indicated elevated liver enzymes, increased total bilirubin, abnormal kidney function, and coagulopathy. Abdominal ultrasound revealed abnormalities. The patient’s Swansea score was 6, leading to a diagnosis of AFLP, and an emergency cesarean section was performed. The patient’s liver enzymes improved within a day post-surgery, but persistent coagulopathy postoperatively led to the development of an abdominal subcutaneous hematoma. After treatment with clotting factor supplementation, coagulation function gradually improved within four days.
Conclusion: Early detection and timely termination of pregnancy can improve outcomes in cases of AFLP. Post-cesarean section, vigilance is required for persistent coagulopathy, which may lead to the development of abdominal subcutaneous hematomas.