bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical outcomes after emergency transarterial renal embolization: a retrospective study
Authors: Grange Rémi , Magand Nicolas , Lutz Noémie , Lanoiselee Julien , Leroy Stéphanie , Boutet Claire , Grange Sylvain
Published: December 2024

Background

Studies on emergency transarterial embolization (TAE) of renal arterial injuries are rare. The aim of this retrospective study was to evaluate clinical outcomes after emergency transarterial renal embolization.

Material and methods

Between January 1st, 2013 and January 1st, 2024, all consecutive patients treated for renal arterial injuries by TAE in emergency settings were retrospectively reviewed. Demographic, biological and angiographic data were recorded. The inclusion criteria were all patients ≥ 18-years-old treated by emergency TAE for renal vascular injury. Clinical success was defined as the resolution of bleeding signs without the need for repeat TAE, surgery, death related to massive blood loss during this period, without functional impairment (> 50% of parenchyma volume or onset of chronic kidney disease) following TAE.

Results

During the inclusion period, 79 procedures were performed. The median age was 60[39–73] years old. On preoperative CT, ≥ 1 pseudoaneurysm was detected in 36(45.6%) patients, and active bleeding in 47(65.8%) patients. The preoperative median haemoglobin rate was 8.9[7.6–11] g/dl, and 37(46.8%) patients required red blood cell transfusions. The main aetiologies of arterial injury were blunt trauma (n = 19) and renal biopsy (n = 17). No severe adverse events were reported. Clinical success was reported in 74(93.7%) of the procedures. Three (3.8%) repeat embolizations were required, and were clinically successful. During the median follow-up of 7[1.5–35.5] months, 9(11.4%) patients died, of which 5(6.3%) occurred within 30 days.

Conclusion

The present study reports high clinical success, low complications and low rebleeding rates of emergency renal TAE.
Integrated safety analysis of tofacitinib from Phase 2 and 3 trials of patients with ankylosing spondylitis
Authors: Deodhar Atul , Akar Servet , Curtis Jeffrey R. , El-Zorkany Bassel , Magrey Marina , Wang Cunshan , Wu Joseph , Makgoeng Solomon B. , Vranic Ivana , Menon Sujatha , Fleishaker Dona L. , Diehl Annette M. , Fallon Lara , Yndestad Arne , Landewé Robert B. M.
Published: December 2024

Objectives

Describe tofacitinib safety from an integrated analysis of randomized controlled trials (RCTs) in patients with ankylosing spondylitis (AS).

Method

Pooled data from Phase 2 (NCT01786668; 04/2013–03/2015)/Phase 3 (NCT03502616; 06/2018–08/2020) RCTs in AS patients were analyzed (3 overlapping cohorts): 16-week placebo-controlled (tofacitinib 5 mg twice daily [BID] [n = 185]; placebo [n = 187]); 48-week only-tofacitinib 5 mg BID (n = 316); 48-week all-tofacitinib (≥ 1 dose of tofacitinib 2, 5, or 10 mg BID; n = 420). Baseline 10-year atherosclerotic cardiovascular disease (ASCVD) risk was determined in patients without history of ASCVD (48-week cohorts). Adverse events (AEs)/AEs of special interest were evaluated/compared with findings from other tofacitinib programs (16 Phase 2/Phase 3 rheumatoid arthritis [RA]; 2 Phase 3 psoriatic arthritis [PsA] RCTs) and a real-world cohort of AS patients initiating biologic disease-modifying antirheumatic drugs (US MarketScan).

Results

Most patients (> 75%; 48-week cohorts) without history of ASCVD had low baseline 10-year ASCVD risk. One patient (tofacitinib 5 mg BID; in all 3 cohorts) had a serious infection (aseptic meningitis). Herpes zoster (non-serious) occurred in the 48-week only-tofacitinib 5 mg BID (n = 5 [1.6%]) and all-tofacitinib (n = 7 [1.7%]; one multi-dermatomal [tofacitinib 10 mg BID]) cohorts. No deaths, opportunistic infections, tuberculosis, malignancies, major adverse cardiovascular events, thromboembolic events, gastrointestinal perforations occurred. Limitations: short RCT durations/low patient numbers within cohorts.

Conclusion

Tofacitinib 5 mg BID was well tolerated to 48 weeks in AS patients; safety profile was consistent with RA/PsA clinical programs and a cohort of AS patients from US routine clinical practice.

Clinical trial registration numbers

NCT01786668 (2013-02-06); NCT03502616 (2018-04-11).
Wildfire management decisions outweigh mechanical treatment as the keystone to forest landscape adaptation
Authors: Furniss Tucker J. , Povak Nicholas , Hessburg Paul F. , Salter R. Brion , Duan Zhuoran , Wigmosta Mark
Published: December 2024

Background

Modern land management faces unprecedented uncertainty regarding future climates, novel disturbance regimes, and unanticipated ecological feedbacks. Mitigating this uncertainty requires a cohesive landscape management strategy that utilizes multiple methods to optimize benefits while hedging risks amidst uncertain futures. We used a process-based landscape simulation model (LANDIS-II) to forecast forest management, growth, climate effects, and future wildfire dynamics, and we distilled results using a decision support tool allowing us to examine tradeoffs between alternative management strategies. We developed plausible future management scenarios based on factorial combinations of restoration-oriented thinning prescriptions, prescribed fire, and wildland fire use. Results were assessed continuously for a 100-year simulation period, which provided a unique assessment of tradeoffs and benefits among seven primary topics representing social, ecological, and economic aspects of resilience.

Results

Projected climatic changes had a substantial impact on modeled wildfire activity. In the Wildfire Only scenario (no treatments, but including active wildfire and climate change), we observed an upwards inflection point in area burned around mid-century (2060) that had detrimental impacts on total landscape carbon storage. While simulated mechanical treatments (~ 3% area per year) reduced the incidence of high-severity fire, it did not eliminate this inflection completely. Scenarios involving wildland fire use resulted in greater reductions in high-severity fire and a more linear trend in cumulative area burned. Mechanical treatments were beneficial for subtopics under the economic topic given their positive financial return on investment, while wildland fire use scenarios were better for ecological subtopics, primarily due to a greater reduction in high-severity fire. Benefits among the social subtopics were mixed, reflecting the inevitability of tradeoffs in landscapes that we rely on for diverse and countervailing ecosystem services.

Conclusions

This study provides evidence that optimal future scenarios will involve a mix of active and passive management strategies, allowing different management tactics to coexist within and among ownerships classes. Our results also emphasize the importance of wildfire management decisions as central to building more robust and resilient future landscapes.
Effect of pyrolytic temperature on the adsorption of Pb(II) from synthetic wastewater onto bamboo chopstick biochar: a conventional vs. microwave-assisted pyrolysis approach
Authors: Mabaso Thembeka , Lo Shang-Lien , Chiueh Pei-Te
Published: December 2024

This study investigated the effects of different pyrolytic temperatures on Pb(II) adsorption from synthetic wastewater using waste bamboo chopsticks (BCs) produced via conventional and microwave-assisted pyrolysis. Eleven biochars were prepared and characterized using Brunauer‒Emmett‒Teller analysis, elemental analysis, scanning electron microscopy, and Fourier transform infrared spectroscopy. Thereafter, the selected biochars were further analyzed through batch adsorption studies. The influence of adsorbent dose, initial Pb(II) concentration, and contact time on the removal of Pb(II) from synthetic wastewater was studied. For the adsorbent dose, good removal efficiencies and adsorption capacities were observed at an adsorbent dose of 2 g L−1 and at an initial concentration of 50 mg L−1. For the initial Pb(II) concentration, high adsorption capacities and removal efficiencies were observed at 50 mg L−1 for concentrations ranging from 5 to 100 mg L−1. The contact time reached equilibrium within 24 h, where BC 450 W had the highest removal efficiency of 99.9%. Furthermore, the Langmuir isotherm model best represented the adsorption of Pb(II) onto biochar, with the highest qm of 81 mg g−1 at R2 = 0.978. Pseudo-second-order kinetics provided the best overall fit for the adsorption kinetics of the biochars, with R2 = 1.00 for BC 450 W and BC 700 °C. Among the many chemisorption processes identified in previous studies, surface complexation has been identified as a possible adsorption mechanism for Pb(II) on the biochars produced. BC biochar could be a sustainable means for remediating polluted mine water and managing waste.
Blurring the lines: an empirical examination of the interrelationships among acceptability, appropriateness, and feasibility
Authors: Fehlberg Zoe , Stark Zornitza , Klaic Marlena , Best Stephanie
Published: December 2024

Background

Acceptability, appropriateness, and feasibility are established implementation outcomes used to understand stakeholders’ perceptions of an intervention. Further, they are thought to provide insight into behaviors, such as adoption. To date, measurement instruments for the three outcomes have focused on their individual assessment whilst nodding to the idea that they may interrelate. Despite this acknowledgment, there is little empirical evidence of the association among these constructs. Using the example of genetic health professionals providing additional genomic results to patients, this study aimed to examine the interrelationships among acceptability, appropriateness, and feasibility.

Methods

A sequential explanatory mixed methods approach was employed. All genetic counsellors and clinical geneticists involved in a large research program were invited to complete pre/post surveys using existing measures of acceptability, appropriateness, and feasibility. Follow-up interviews, informed by the survey results, explored clinicians’ perspectives of the three outcomes in relation to providing additional genomic results to patients. To categorize interrelationships and generate feedback loops, survey data were analyzed using descriptive and correlation statistics and interpreted alongside interview data analyzed using content analysis.

Results

The survey results (pre n = 53 and post n = 40) for each outcome showed a similar midpoint mean, wide ranges, and little change post implementation (Acceptability: pre M = 3.55, range 2–5 post M = 3.56, range 1.5–5; Appropriateness: pre M = 3.35, range 1–5, post M = 3.48, range 1–5; Feasibility: pre M = 3.30, post M = 3.32; range 1.25–5). The strength of correlation among outcomes ranged from 0.54 to 0.78. Five interrelationships were categorized from analysis of interview data (n = 14) and explain how clinicians’ perceptions of the intervention, positive or negative, were determined by interrelating factors of acceptability, appropriateness, and feasibility and that in different scenarios, the function and emphasis of importance among outcomes switched.

Conclusions

Rather than existing separately, our study promotes the need to consider interrelationships among acceptability, appropriateness, and feasibility to better characterize clinicians’ perceptions of complex health care interventions and aid in the development of implementation strategies that have real world impact. Further, in the interest of reducing research waste, more research is needed to determine if the outcomes could serve as proxies for each other.
A study protocol for the policy intervention design and development of the implementation strategies for direct access to physiotherapists in primary care: a sequential mixed-method study using implementation mapping and a Delphi survey
Authors: Yeoh Eng Kiong , Yam Carrie Ho Kwan , Ip Ethan Ming Yin , Chow Tsz Yu , Hung Chi Tim
Published: December 2024

Background

In many Asian jurisdictions, patients are required to obtain referrals from registered doctors before consulting physiotherapists. In contrast, countries such as the United States, the United Kingdom, and Australia have a direct access model for physiotherapists designed across different healthcare settings and under prescribed conditions. While research has demonstrated the benefits of direct access, issues remain on the appropriate policy design for direct access in the context of patient safety and organizational challenges in the implementation. Recently the policy to allow direct access in primary care context is being considered in Hong Kong. This study aims to examine the intervention design options for the policy of direct access to physiotherapists and identify corresponding implementation strategies, to inform the appropriate intervention design for direct access to physiotherapists and the implementation strategies.

Methods

We adopt a systematic process for developing the design of the policy and the implementation strategies using an Implementation Mapping approach informed by Consolidated Framework for Implementation Research (CFIR). We will conduct literature reviews to understand the different aspects of policy intervention design and employ qualitative in-depth interviews and focus group discussions to understand key stakeholders’ perspectives related to the direct access model. The identified barriers and facilitators associated with policy implementation of an acceptable intervention design will inform the development of an effective implementation strategy tailored to the implementation context. Our approach will involve mapping the research evidence and the subsequent findings from the stakeholders’ deliberations into the CFIR domains and referencing the Expert Recommendations for Implementing Change (ERIC) to develop the acceptable intervention characteristics and the corresponding implementation strategies. These insights will be further validated in a Delphi Expert Survey, for a consensus-based approach.

Discussion

This study employs a sequential mixed-method approach to explore the intervention characteristics for an acceptable intervention design in the policy formulation and the corresponding implementation strategy for direct access to physiotherapists. Integrating research insights into actionable policy recommendations and refining these recommendations in a Delphi Survey will inform the appropriate policy intervention design and implementation strategy for direct access to physiotherapy services.
Virtuous spaces, virtual places: institutionalizing values on ethical consumerism in the Indian toy industry through field-configuring events
Authors: Nath Saheli
Published: December 2024

Focusing on India's toy industry, this study investigates how field-configuring events facilitate the institutionalization of ethical consumerism in emerging markets. Through virtual ethnographic analysis of the First India Toy Fair 2021, we examine how digital platforms enable institutional change processes. Drawing on institutional theory, we identify three key mechanisms through which the fair shaped ethical consumption practices: normative space creation, regulatory framework development, and cultural-cognitive meaning making. The fair served as a platform where stakeholders collectively defined ethical practices, negotiated quality standards, and legitimated traditional production methods within contemporary sustainability discourse. Our findings reveal how virtual field-configuring events can transcend geographical boundaries to enable broader participation in institutional change processes, while also highlighting the complex interplay between traditional craft values and modern market demands. The study demonstrates how traditional practices can provide templates for sustainable production while meeting contemporary consumer expectations. These insights contribute to understanding how ethical markets are moralized in emerging economies and how virtual spaces can support the preservation and evolution of traditional craft sectors.
Effect of shockwave therapy on plantar fasciitis in postnatal women: a randomized controlled trial
Authors: Rahman Yomna M. Abd El , Emara Hala H. , Samir Sameh H. , El-Shafei Manal A.
Published: December 2024

Background

Plantar fasciitis (PF) is a widespread foot issue that can be especially frustrating during pregnancy; it is accompanied by pain in the heel, falling, disability, and reduced quality of life (QoL). This study aimed to explore the efficacy of shockwave therapy (SWT) on PF in postnatal women.

Material and methods

Forty-four postnatal women with PF were randomly distributed into two groups equal in number. Group (A) was given analgesic drugs (Ibuprofen 200 mg, one tablet/day) and performed plantar fascia-stretching exercises only for 6 weeks, while group (B) followed the same treatment as group (A) plus SWT, twice weekly for 6 weeks. All participating women in both groups were evaluated pre- and post-treatment through the Numeric Pain Rating Scale (NPRS) to evaluate pain intensity levels, the Foot Function Index (FFI) to evaluate foot pain and disability related to PF, and the Six-Minute Walk Test (SMWT) to evaluate the functional exercise capacity and QoL of the affected women.

Results

Both groups showed significant improvements in all outcomes post-treatment (p = 0.001). Group B demonstrated superior improvements in NPRS (p = 0.001), FFI (p = 0.022), and SMWT (p = 0.001) compared to group A.

Conclusion

Shockwave therapy is a beneficial method for reducing pain intensity, enhancing foot functional level, and improving QoL of postpartum women with plantar fasciitis.
Longitudinal Testing of Circulating Tumor DNA in Patients With Metastatic Renal Cell Carcinoma
Authors: Basu Arnab , Au Cherry , Kommalapati Ajitha , Kandala Hyndavi , Sudhaman Sumedha , Mahmood Tamara , Carson Carcia , Pajak Natalia , Dutta Punashi , Calhoun Mark , Malhotra Meenakshi , ElNaggar Adam C. , Liu Minetta C. , Ferguson III James , Peyton Charles , Rais-Bahrami Soroush , Tan Alan
Published: December 2024

PURPOSE

Tumor-informed circulating tumor DNA (ctDNA) has shown promise as a biomarker for treatment response monitoring (TRM) in a variety of tumor types, with the potential to improve clinical outcomes. We evaluated ctDNA status and dynamics during surveillance and as part of TRM with clinical outcomes in both patients with clear cell renal cell carcinoma (ccRCC) and non–clear cell renal cell carcinoma (nccRCC) treated with standard-of-care immunotherapy or targeted therapy regimens.

METHODS

This was a multicenter retrospective analysis of real-world data obtained from commercial ctDNA testing (Signatera, Natera, Inc) in patients with metastatic RCC. Clinical data were collected on International Metastatic RCC Database Consortium (IMDC) risk category, pathologic subtype, and grade.

RESULTS

The cohort comprised 92 patients (490 plasma samples) including both clear cell and non–clear cell histological subtypes (ccRCC: 79.3%; nccRCC: 14.1%; unclassified: 6.5%). Most of the patients belonged to the IMDC intermediate-risk category (75%, 69/92). Median follow-up was 10 months (range, 4.2-25.8). ctDNA dynamics were assessed in 56 patients on treatment, and ctDNA status was analyzed in the surveillance cohort (n = 32 patients). Serial ctDNA negativity or clearance correlated with improved progression-free survival (PFS) compared with those who became or were persistently ctDNA positive on therapy (hazard ratio [HR], 3.2;
P
= .012). In the surveillance cohort, patients with positive ctDNA longitudinally experienced significantly inferior PFS (HR, 18;
P
= .00026) compared with those who were serially negative.

CONCLUSION

Collectively, we show that serial ctDNA monitoring provides prognostic information for patients undergoing treatment or surveillance, and our findings demonstrate high concordance between ctDNA status/dynamics and subsequent clinical outcomes.
What Can Dialectics Change in the System?
Authors: Chukhrov Keti
Published: December 2024

This article maps the differences in the application of systems method in Marxist dialectics, cybernetics, and poststructuralism. It studies the impact of algorithmic rationality on the speculative lexicons of philosophy—especially when philosophical dialectics is defined as nothing more than quasi-cybernetic recursivity. According to Yuk Hui, the decline of philosophy and dialectics can be contested only by second-order cybernetics as the proper successor of philosophical speculation. To dispute this bold assumption, the article embarks on a comparative inquiry into the systemic method in Marx’s political economy, cybernetics, and poststructuralism, respectively. Reference to the comparative analysis of systems method and Marxist dialectics by Igor Blauberg and Eric Yudin allows one to challenge the thesis according to which the preconditions of dialectics can be developed in the frame of cybernetic recursivity. It enables one to go farther in demonstrating the differences between the Marxist application of systems, which includes dialectical procedures and genesis, and cybernetic systematics, in which these procedures are redundant. Lev Vygotsky, Evald Ilyenkov, and Merab Mamardashvili are brought in as the exemplary methodists who elaborate Marxist methodology to encompass genesis and dialectical difference within systemic abstraction.
Flood Dashing against the Temple of the Dragon King
Authors: Zhang Zhen
Published: December 2024

Toward the end of the 1950s, China and the Soviet Union were heading down two different paths, ultimately leading to the disastrous Sino-Soviet split. The Sino-Soviet film coproduction Wind from the East (Feng cong dongfang lai 風從東方來, 1959), a film to celebrate the ten-year anniversary of the founding of the People's Republic of China, inadvertently captures such a historical transition. Situating the film in the context of transnational ecocinemas, this article looks into the relationship between natural disasters and Sino-Soviet brotherhood in 1959. The author argues that the film captures a somewhat ambiguous Sino-Soviet bond under threat, oscillating between a nostalgic communist internationalism, on the one hand, and, on the other, a rising and subtle Chinese nationalism. The ecological crises, flooding in particular, serve as an unpronounced and unspecified threat to the Sino-Soviet brotherhood, which could be annihilated by the Sino-Soviet bond. The film captures a moment of natural and political, propagandistic and aesthetic “climate change,” pointing to a future of Sino-Soviet cooperation without sacrificing the Chinese national interests.
Il relitto di Aghia Galini
Authors: Μπροκαλάκης Γεώργιος
Published: December 2024

Το αποκαλούμενο ναυάγιο της Αγ. Γαλήνης αποτελείται από τέχνεργα, στην πλειονότητά τους χάλκινα, που ήρθαν στο φως από την ίδια θέση σε διαφορετικές χρονικές στιγμές στον κόλπο της Μεσαράς στην Κρήτη. Στο πλαίσιο της διδακτορικής διατριβής το σύνολο μελετήθηκε συστηματικά και έγινε προσπάθεια ερμηνεία του, λαμβάνοντας υπόψη σύνολα με ανάλογα χαρακτηριστικά, τα οποία έχουν βρεθεί στη θάλασσα αλλά και στη στεριά.
Looking at Social Interactions in Medical Education with Dual Eye-Tracking Technology: A Scoping Review
Authors: Lorenz Johannes , Zevano Juliane , Otto Nils , Schneider Bertrand , Papan Cihan , Missler Markus , Darici Dogus
Published: December 2024

Purpose Social interactions are fundamental to effective medical practice, yet assessing these complex dynamics in educational settings remains challenging. This review critically examines the emerging use of dual eye-tracking technology as a novel method to quantify, analyze, and enhance social interactions within medical education contexts. Materials and Methods We performed a scoping review of the literature, focusing on studies that utilized dual eye-tracking within medical education contexts. Our search included multiple databases and journals. We extracted information on technical setups, areas of application, participant characteristics, dual eye-tracking metrics, and main findings. Results Ten studies published between 2012 and 2021 met the inclusion criteria, with 90% utilizing dual screen-based- and 10% dual mobile eye-tracking. All studies were conducted in the context of surgical training, primarily focusing on laparoscopic surgery. We identified two main applications of dual eye-tracking: (1) as an educational intervention to improve collaboration, (2) as a diagnostic tool to identify interaction pattern that were associated with learning. Key metrics included joint visual attention, gaze delay and joint mental effort. Conclusion Dual eye-tracking offers a promising technology for enhancing medical education by providing high-resolution, real-time data on social interactions. However, current research is limited by small sample sizes, outdated technology, and a narrow focus on surgical contexts. We discuss the broader implications and potential for medical education research and practice.
Overcoming the Silencing of Doxycycline-Inducible Promoters in hiPSC-derived Cardiomyocytes
Authors: Guichardaz Michelle , Bottini Sveva , Balmas Elisa , Bertero Alessandro
Published: December 2024

Background Human induced pluripotent stem cells (hiPSCs) are pivotal for studying human development, modeling diseases, and advancing regenerative medicine. Effective control of transgene expression is crucial to achieve temporal and quantitative precision in all of these contexts. The doxycycline (dox)-inducible OPTi-OX system, which integrates the Tet-On 3G transactivator and dox-responsive transgene at the hROSA26 and AAVS1 genomic safe harbors (GSHs), respectively, offers a promising solution. Yet, transgene silencing, particularly in hiPSC-derived cardiomyocytes (hiPSC-CMs), limits its utility. Methods To address this, we evaluated strategies to enhance dox-inducible transgene expression. We compared two promoters, TRE3VG and T11, for activity and stability, and investigated the addition of a Ubiquitous Chromatin Opening Element (UCOE) to reduce silencing. We also tested relocating the transgene cassette to the CLYBL GSH, and employed sodium butyrate (SB), a histone deacetylase inhibitor, to restore promoter activity. Transgene expression was assessed via flow cytometry and real-time quantitative PCR. Results TRE3VG exhibited higher activity than T11, but both were prone to silencing. UCOE did not enhance promoter activity in hiPSCs, but modestly reduced silencing in hiPSC-CMs. Targeting the CLYBL locus improved promoter activity compared to AAVS1 in both hiPSCs and hiPSC-CMs. SB restored activity in silenced inducible promoters within hiPSC-CMs, but compromised hiPSC viability. Unexpectedly, Tet-On 3G was silenced in some clones and could not be reactivated by SB. Conclusions These findings underscore the need for integrating multiple strategies, including careful GSH selection, improved cassette design, epigenetic modulation, and clone screening, to develop robust dox-inducible systems that retain functionality during hiPSC differentiation.
Statistical analysis plan for the Petal trial: the effects of parental touch on relieving acute procedural pain in neonates
Authors: Baxter Luke , Hauck Annalisa G.V. , Bhatt Aomesh , Cobo Maria M. , Hartley Caroline , Marchant Simon , Poorun Ravi , van der Vaart Marianne , Slater Rebeccah
Published: December 2024

Background Infants undergo multiple clinically-required painful procedures during their time in hospital, and there is an increasing desire from both parents and clinical staff to have parents directly involved in their newborn’s pain relief. To avoid biases due to selective analysis and reporting, a clinical trial’s statistical analysis plan (SAP) should be finalised and registered prior to dataset lock and unblinding. Here, we outline the SAP for the Petal trial, which was registered on the ISRCTN registry prior to dataset lock and unblinding. Methods The Petal trial is a multicentre, individually randomised, parallel-group interventional superiority trial. The study involves in-patient neonates born at or after 35+0 weeks gestation with a postnatal age of ≤7 days, in two hospital research sites (John Radcliffe Hospital, Oxford, UK; Royal Devon and Exeter Hospital, Exeter, UK). The primary objective is to investigate the potential efficacy of a non-pharmacological parent-led stroking intervention on reducing the magnitude of neonates’ noxious stimulus-evoked brain activity. The primary outcome is the neonate’s brain activity recorded using electroencephalography (EEG) in response to a heel lance blood sampling procedure. Secondary outcomes include neonatal clinical pain scores and tachycardia, and parental anxiety. The study hypothesis is neonates’ pain responses and parents’ anxiety scores are lower in the intervention group. Randomisation will be via a minimisation algorithm to maintain balance in five prognostic factors. Conclusions Paediatric pain trials have been highlighted by regulatory bodies as an important and challenging topic, with interest increasing in brain imaging outcomes. The Petal trial, to which this SAP relates, is part of a larger effort of establishing a brain-based EEG outcome measure of infant pain for use in clinical trials. This SAP is thus likely to be of interest to those in academia, pharmaceutical companies, and regulatory bodies. Trial registration ClinicalTrials.gov: NCT04901611, 25/05/2021; ISRCTN: ISRCTN14135962, 23/08/2021).
The genome sequence of the greater two-lined sac-winged bat Saccopteryx bilineata, Temminck, 1838 (Emballonuridae, Emballonurinae)
Authors: Lim Burton K. , Pippel Martin , Brown Thomas , Winkler Sylke , Pieri Myrtani , Mai Meike , Myers Eugene W. , Teeling Emma C. , Vernes Sonja C. ,   Bat1K consortium
Published: December 2024

We present a genome assembly from an individual male Saccopteryx bilineata (Chordata; Mammalia; Chiroptera; Emballonuridae). The genome sequence is 2.62Gb in span. The majority of the assembly is scaffolded into 13 chromosomal pseudomolecules, with the X sex chromosome assembled.
The genome sequence of the striped dolphin, Stenella coeruleoalba (Meyen, 1833)
Authors: Davison Nicholas J. , Morin Phillip A. ,   Wellcome Sanger Institute Tree of Life Management, Samples and Laboratory team,   Wellcome Sanger Institute Scientific Operations: Sequencing Operations,   Wellcome Sanger Institute Tree of Life Core Informatics team,   Tree of Life Core Informatics collective,   Darwin Tree of Life Consortium
Published: December 2024

We present a genome assembly from an individual male Stenella coeruleoalba (the striped dolphin; Chordata; Mammalia; Artiodactyla; Delphinidae). The genome sequence has a total length of 2,691.40 megabases. Most of the assembly is scaffolded into 23 chromosomal pseudomolecules, including the X and Y sex chromosomes. The mitochondrial genome has also been assembled and is 16.39 kilobases in length.
Una propuesta de innovación docente en el Grado de Publicidad y Relaciones Públicas
Authors: Gordillo-Rodríguez María-Teresa
Published: December 2024

El presente capítulo describe la aplicación de un ciclo de mejora en el aula
(CIMA) en la asignatura de Estrategia Publicitaria, del Grado en Publicidad y Relaciones Públicas. Se centra en el contenido «La definición del público objetivo.
Estrategias de segmentación», correspondiente al tercer tema de la asignatura
según se describe en el proyecto docente. El alumnado cuenta con una base conceptual como punto de partida que permite abordar directamente los contenidos
de más profundamente. Durante cuatro sesiones, el alumnado participa activamente en distintas actividades orientadas a comprender la importancia de definir el target de una campaña publicitaria aplicando los criterios de segmentación.
Tras la aplicación del CIMA, los resultados del análisis de los cuestionarios son
positivos: por lo general, el alumnado se mantiene o sube de nivel, si bien en
ciertas preguntas los resultados no son tan positivos y apuntan a una modificación del futuro CIMA.
Descripción, análisis y valoración del ciclo de mejora experimentado en la asignatura Epidemiología y Salud Pública, del Grado en Fisioterapia
Authors: Marín López Juan José
Published: December 2024

El CIMA que exponemos se ha implementado con el alumnado del primer
curso del Grado en Fisioterapia y del Doble Grado en Fisioterapia y Ciencias de la
Actividad Física y del Deporte. Este curso supone un cambio radical en la implicación y responsabilidad que el alumnado debe asumir al incorporarse a la Universidad. A pesar de ello, no resulta raro que al cabo de unas pocas semanas
comiencen a asumir un papel pasivo en el aula, limitándose a escuchar las aportaciones del profesorado y a visualizar las presentaciones que se proyectan. Para
romper esa dinámica se diseñó la presente intervención, con el objetivo de lograr una mayor implicación y una mejor asimilación de los contenidos tratados.
La metodología ensayada parte de un trabajo personal que, posteriormente, se
contrasta, discute y mejora en pequeños grupos. Posteriormente, tras una discusión en el grupo de clase, se aportan materiales de contraste que permiten corregir, afianzar y/o ampliar esos contenidos, surgiendo nuevas necesidades y temas
que se trabajan, secuencialmente, siguiendo ese mismo esquema de trabajo.
Innovando a través de un ciclo de mejora en el aula en la asignatura de Enfermería Clínica II
Authors: Fernández León Pablo
Published: December 2024

Se llevó a cabo un Ciclo de Mejora en el Aula (CIMA) en la asignatura de Enfermería Clínica II del Centro Universitario de Enfermería de Cruz Roja, adscrito a la
Universidad de Sevilla, a lo largo de cinco talleres en grupo pequeño, de dos horas de duración cada uno, con un total de 10 horas. Participaron 58 estudiantes y
el enfoque de la actividad se centró en la asistencia a pacientes con alteraciones
en los patrones nutricional-metabólico y de eliminación, a través del Aprendizaje
Basado en Problemas (ABP). Se evaluó el nivel de adquisición de conocimientos
del alumnado mediante un cuestionario pre y post. Los resultados comparativos
de este cuestionario muestran una mejora en el aprendizaje en el grupo. Además,
se aplicó un cuestionario de satisfacción relativo al CIMA y a la labor docente que
también mostró resultados positivos. Por tanto, se concluye que la experiencia
fue positiva. No obstante, se recomiendan algunas mejoras como la distribución
de algunos tiempos y el seguimiento a largo plazo para determinar el alcance de
la innovación.
Innovación en la docencia de la asignatura de Terapias Complementarias de Aplicación en Podología mediante un Ciclo de Mejora en el Aula-CIMA
Authors: Távara-Vidalón Priscila
Published: December 2024

Este Ciclo de Mejora en el Aula (CIMA) se desarrolló en la asignatura de Terapias Complementarias de Aplicación en Podología como parte de un proceso de
cambio en el modelo docente tradicional. Los objetivos fueron mejorar la forma
de enseñanza y aprendizaje de los estudiantes de Grado en Podología. Se ha implementado durante el segundo cuatrimestre del curso 2023-2024. Se utilizaron
cuestionarios iniciales y finales para la evaluación de una metodología que se
centra en la creación de problemas y su correspondiente secuencia de actividades para generar conocimiento en los estudiantes. Los resultados obtenidos
muestran que se ha producido una mejora en el aprendizaje de la asignatura al
igual que una mayor preferencia por este tipo de enseñanza. A su vez, ha supuesto
una gran satisfacción y motivación tanto de los estudiantes como del docente.
La importancia de la interpretación de resultados en Toxicología. Ciclo de mejora en el aula de Laboratorio de Farmacia
Authors: Plata Calzado Cristina
Published: December 2024

En el presente trabajo se muestra el diseño y los resultados obtenidos tras
la implementación de un Ciclo de Mejora en el Aula (CIMA) en el módulo de Toxicología de la asignatura de Laboratorio de Farmacia del 4º curso del Grado en
Farmacia durante el curso 2023/24. Las prácticas se centran en el aprendizaje de
los mecanismos de defensa del organismo frente al estrés producido por un fármaco. El principal objetivo del CIMA fue mejorar la capacidad de análisis de los
estudiantes a la hora de interpretar los resultados obtenidos, así como incentivar
la participación del alumnado en el aula. Los resultados mostraron un avance de
los estudiantes en las escaleras de aprendizaje establecidas en el cuestionario final respecto al inicial, además de una mayor participación del alumnado. Así, estos resultados ponen de manifiesto que la aplicación de este CIMA permite que
los estudiantes alcancen los objetivos planteados poniendo el foco de aprendizaje en los alumnos.
Resolución de casos reales en las oficinas de farmacia de la provincia de Sevilla. Ciclo de mejora en el aula de Legislación, Gestión y Planificación Farmacéutica
Authors: Cayero Otero Mª Dolores
Published: December 2024

Este trabajo incluye el desarrollo y los resultados que se han obtenido tras la
aplicación de un Ciclo de Mejora en el Aula (CIMA) en la asignatura obligatoria Legislación, Gestión y Planificación Farmacéutica del 4º curso del Grado en Farmacia (curso 2023-2024). La temática principal de las prácticas es que los alumnos
conozcan la legislación vigente y el funcionamiento básico de una oficina de farmacia (OF) ya que, en meses venideros, se enfrentarán a sus prácticas tuteladas.
Por lo tanto, el principal objetivo del presente CIMA es la integración de los alumnos en situaciones reales de casos extraídos de diferentes OF de la provincia de
Sevilla a través de un role-play donde actuarán como pacientes o farmacéuticos.
Los alumnos han mostrado gran interés en este tipo de aprendizaje, obteniéndose resultados que ponen de manifiesto la utilidad práctica del CIMA para que
los alumnos aprendan y sean capaces de desarrollar lo aprendido. Así mismo,
ellos se sienten más motivados e integrados con la asignatura, sintiéndose como
auténticos profesionales.
Ensayos clínicos y pruebas diagnósticas: Diseño y evaluación de un ciclo de mejora en el aula en prácticas de salud pública
Authors: García-Cabrera Emilio
Published: December 2024

Se ha llevado a cabo la aplicación de un Ciclo de Mejora en el Aula (CIMA)
en las prácticas de la asignatura de Salud Pública del grado en Farmacia. Previo
a la realización del CIMA las prácticas de la asignatura se realizaban en contextos prácticos alejados del estudiante y que no conseguían su implicación activa.
El objetivo principal del CIMA fue introducir una nueva metodología para la realización de dichos supuestos prácticos basado en la resolución de problemas, inmersivos en un supuesto práctico más real. El CIMA se ha aplicado y realizado en
el tiempo planificado, con discrepancias en los tiempos reales de las actividades.
Los alumnos han respondido positivamente en la mayoría de los aspectos relacionados con el CIMA, incrementando su participación e implicación, y mejorando
el aprendizaje como demuestran los cuestionarios inicial y final junto con las escaleras de aprendizaje. En conclusión, la aplicación del CIMA para hacer más aplicadas las prácticas muestra áreas de mejora y buenos resultados iniciales.
Aprendiendo los procesos de fabricación por deformación plástica con la aplicación de los Ciclos de Mejora en el Aula-CIMA
Authors: Rodríguez Albelo Luisa Marleny
Published: December 2024

En este capítulo se presentan los resultados de la aplicación de los Ciclos
de Mejora en el Aula (CIMA) en la asignatura Procesos de Fabricación, del Grado de
Ingeniería Química Industrial de la Escuela Politécnica Superior de la Universidad de Sevilla. El objetivo principal de este ejercicio es mejorar el aprendizaje de
los procesos de fabricación que es una asignatura muy práctica, que requiere conocimientos previos de ingeniería de materiales. El CIMA ha incentivado la participación de los alumnos en las clases, ha promovido el debate e intercambio de
conocimientos entre los alumnos, avivando la curiosidad por saber más del tema.
Además, aplicar el CIMA me ha dotado de nuevas herramientas de enseñanza, y
evaluación del aprendizaje de los estudiantes, ha abierto nuevas perspectivas
para que con cada nueva clase a la que me enfrente tenga a mi disposición recursos más eficientes para enseñar.
Ciclo de Mejora en el Aula en la asignatura de Análisis y Diseño de Datos y Algoritmos: Complejidad y árboles
Authors: Olivero González Miguel Ángel
Published: December 2024

La ingeniería informática en la Universidad de Sevilla es una ingeniería joven
que se inició en la década de los 80. Uno de los pilares de la ingeniería informática es la capacidad de analizar un problema para diseñar algoritmos capaces de
darles una solución eficaz y optimizando el uso de recursos. La asignatura Análisis y Diseño de Datos y Algoritmos ofrece estas competencias a los estudiantes y,
por tanto, se considera una buena oportunidad para mejorar la base del aprendizaje de los estudiantes. Este capítulo describe el desarrollo de un Ciclo de Mejora en el Aula aplicado a esta asignatura y se descubren los desafíos que supone
y las oportunidades que ofrece integrar los cambios diseñados a las sesiones de
clase. Los resultados muestran que los cambios que se proponen son recibidos
positivamente por parte del alumnado en tanto que muestran más interés por el
contenido de la asignatura y un gran porcentaje de los mismos consiguen resolver desafíos complejos.
condición humana y el reconocimiento del individuo como sujeto del derecho internacional:
Authors: Olasolo Héctor , Urueña Sánchez Mario
Published: December 2024

El objetivo de este artículo es analizar la tensión entre la complejidad de la condición humana y el reconocimiento del individuo como sujeto del derecho internacional contemporáneo, particularmente en los regímenes de protección internacional del derecho internacional de los derechos humanos y el derecho internacional penal. La metodología que permitirá abarcar este objetivo se basó en un análisis documental de fuentes filosóficas, doctrinales y convencionales que permiten un debate interdisciplinar que pone en perspectiva la condición humana y las respuestas que desde el derecho internacional se le dan a esta. Se concluye con un llamado a reactivar el humanismo centrado en la dignidad humana que deje atrás al racionalismo instrumental como criterio de configuración de los sistemas jurídicos.
Instrumental Colorimetric Evaluation of Combined Enamel and Dentin Composite Resins Compared to the Vita Classic Shade Guide
Authors: Sarmiento-Cornejo Jaime , Sarmiento-Oesterreich Raimundo , Hidalgo-Roldán Leslie , Antonio-Benavente Nicolás , Godoy-Álvarez Bárbara , Villalobos-Castro Pablo
Published: December 2024

Accurate color determination in dental restorations is crucial for achieving aesthetically pleasing and functional results. Traditionally, color selection has been performed using visual methods, which are subject to observer variability and factors such as lighting and experience. However, the use of instrumental technologies like spectrophotometry has allowed for greater objectivity and reproducibility in color measurement. This study aims to evaluate the accuracy of color determination in composite resin restorations using spectrophotometry, comparing the results obtained with the Vita Classic shade guide.
A total of 120 samples were prepared using 4 types of composite resins and 3 enamel/dentin combinations (A2, A3, and A3.5), with 0.7 mm thickness for enamel and 1.3 mm for dentin, achieving a final thickness of 2 mm. Color measurements were taken with a Vita™ Easyshade® spectrophotometer, and the results were expressed in terms of ΔE using the CIE Lab* formula. Normality (Shapiro-Wilk) and homoscedasticity (Levene) tests were applied, and one-way ANOVA was used to assess differences between resin brands and shades.
The results showed that, although no statistically significant differences were found in the A2 and A3 shades between brands, the A3.5 shade exhibited significant variations, with Filtek Z350 XT® 3M Espe Solventum being the resin that showed color values closest to the ideal.
DERSU UZALA: NANAY ANİMİZMİNE ÖTEKİNİN GÖZÜNDEN BAKMAK
Authors: Özakın Duygu
Published: December 2024

Bu çalışmada Rus yazar, gezgin ve askerî oryantalist Vladimir Klavdiyeviç Arsenyev’in (1872-1930) Uzak Doğu Rusyası’nda yürütülen keşif gezilerini öykülediği ve etnografik gözlemlerini aktardığı Dersu Uzala adlı günce-romanı konu edinilmiştir. Arsenyev’in bölgede tanıştığı Dersu Uzala, Sibirya’nın yerli halklarından Nanaylara mensup bir avcıdır. Şamanizmi benimseyen bu halkın doğa kavrayışı, etraflarını kuşatan tüm nesnelere birer ruh atfettikleri animizme dayanır. Bilimsel formasyonunu devrin yaygın etnografik kabulleri doğrultusunda şekillendiren Arsenyev ise Nanayların doğayla iletişim pratiklerini, ilkel zihnin kalıntıları olarak yorumlar. Ancak yazar, Dersu’yu yakından tanıdıkça, sözde gelişmiş kentlerde mücadele ettiği benmerkezcilik ve duyarsızlıkla, avcının aynı yeryüzünü paylaştığı canlı-cansız tüm varlıklara gösterdiği karşılıksız merhamet ve hassasiyeti kıyaslamaya başlar. Arsenyev’in sahada edindiği tecrübe, vahşi ve uygar kavramlarına ilişkin Batı merkezli yargılarını, köklü bir dönüşüme uğratır. Devrim ve savaş yıllarında Sovyet otoriteleri ile fikir ayrılığına düşen, eserleri sansürlenen ve aile üyeleri çalışma kampına gönderilip kurşuna dizilen yazarın ömrünün son demleri, derinden bağlandığı Dersu’ya ve bir zamanlar ilkellikle damgaladığı yaşam tarzına yeniden kavuşabilmenin hayaliyle geçer. Bu çalışmada, Rus edebiyatında Nanay imgesine yönelik bir çözümleme ortaya koymak ve Nanay animizminin, Rus bilim camiasında nasıl yorumlandığına dair genel bir çerçeve çizmek amaçlanmıştır. Bu amaçla Arsenyev’in makalelerinden, roman ve mektuplarından; ayrıca Nanay inanışlarının incelendiği ilk folklor kaynaklarından ve çağdaş Rus araştırmacıların Nanay animizmi üzerine kaleme aldıkları güncel yayınlardan faydalanılmıştır. Çalışmada, “ilkel toplum” söyleminin, Çarlık döneminde başlatılan yayılmacılık faaliyetleri kapsamında, hâkim kültürün menfaatlerine hizmet edecek biçimde sahiplenildiği; ancak Arsenyev’in eserlerinde aynı söylemin, Rusya’nın küçük halkları lehine sorgulandığı ortaya konulmuştur.
Colonial Ghosts in Indigenous-British Conflict: A Revisiting of Two 1726 Piracy Trials
Authors: Gilhuis Nicole
Published: December 2024

Abstract: En 1726, cinq hommes qui faisaient partie de la communauté mi'kmaq depuis longtemps furent pendus pour piraterie à Boston. En effectuant l'analyse de sources telles que des bulletins d'information du 18e siècle, des dossiers de procès et des données généalogiques, cet article examine les débats portant sur la place des Métis parmi les Mi'kmaq et la conception élastique de la communauté chez les Autochtones. Cette étude de cas présente également une nouvelle façon de comprendre l'agentivité, les actions et l'expérience vécue d'hommes d'origine acadienne et autochtone – des « fantômes coloniaux » ou des colons disparus des documents de l'époque coloniale britannique – tout en soulignant l'importance de revoir les désignations identitaires utilisées par l'empire et d'accorder davantage de poids aux relations de parenté, à la culture et aux pratiques locales. Abstract: In 1726 five men who had long been part of a Mi'kmaw community were hanged for piracy in Boston. Through an analysis of sources such as 18th-century newsletters, trial records, and genealogical data, this article addresses the debates over the place of Métis among the Mi'kmaq and the practice of Indigenous community elasticity. It also presents a new way to understand the agency, actions, and lived experience of Indigenous Acadian men – "colonial ghosts" or colonists who disappeared from the colonial record – while underlining the importance of revising imperial identity designations as well as of placing greater weight on local kinship, culture, and practice.