bluuebunny/crossref_metadata_2025 huggingface dataset:
Histopathological Comparison and Expression Analysis of COL1A1, COL3A1, and ELN in the Proximal and Distal Ventral Dartos of Patients With Hypospadias: Protocol for Prospective Case-Control Study (Preprint)
Authors: Raharja Putu Angga Risky , Birowo Ponco , Rachmadi Lisnawati , Wibowo Heri , Kekalih Aria , Duarsa Gede Wirya Kusuma , Abbas Tariq , Wahyudi Irfan
Published: December 2024

BACKGROUND

The exact cause of penile curvature in hypospadias remains unknown. Resection of the dartos fascia has been observed to straighten the penis, indicating the involvement of the dartos fascia in the superficial chordee. However, the characteristics of dartos tissue in the distal territory of the ventral penile shaft may differ from those in the proximal aspect of the penile shaft.

OBJECTIVE

This study aims to investigate the distinct histopathological profiles and expression of COL1A1 (collagen type 1), COL3A1 (collagen type 3), and ELN (elastin) in proximal and distal ventral dartos of patients with hypospadias compared to those without hypospadias.

METHODS

This prospective case-control study compares the ventral dartos tissue of patients with hypospadias at different locations with that of patients without hypospadias. Dartos samples will be taken during surgery, with age matching. Histopathology examination uses hematoxylin and eosin and Masson’s trichrome stain. The mRNA expression of COL1A1, COL3A1, and ELN will be quantified using a 2-step reverse transcription–polymerase chain reaction analysis.

RESULTS

Previous studies have documented different characteristics of dartos tissue between patients with hypospadias and those without hypospadias. Some studies even suggest resection of the dartos tissue during hypospadias repair. However, this is the first study to compare the characteristics of ventral dartos tissue in patients with hypospadias based on its location along the penile shaft, suggesting potential differences between the distal and proximal locations. We have obtained ethical approval to conduct a prospective case-control study aimed at elucidating these differences in dartos tissue characteristics. The findings of the study are anticipated to be available by 2025.

CONCLUSIONS

Differences in the characteristics of dartos fascia based on its location may require tailored surgical strategies. If the properties of distal dartos tissue closely mirror those of typical dartos tissue, the possibility of avoiding its excision during hypospadias surgery could be considered.

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/70075
Community Implementation Pilot Trial of STEPS for Autistic Adolescents and Adults (Preprint)
Authors: White Susan W. , Brewe Alexis M , Powell Nicole
Published: December 2024

BACKGROUND

Programming to optimize successful transition into adulthood and build skills for independence is consistent with the goal of improving autonomous living among autistic adults, which is a top stakeholder-identified priority. There has been surprisingly little research, however, on structured curricula targeting transition into adulthood.

OBJECTIVE

This formative community pilot trial of STEPS (Stepped Transition to Employment and Postsecondary Education Success) was designed to test feasibility and effectiveness as implemented by community-based providers and secondarily, to identify factors that affect implementation.

METHODS

This was a two-phase study. Phase 1 involved engagement with a group of community stakeholders to identify factors likely to influence ultimate implementation of STEPS. Phase 2 involved an open pilot trial of STEPS. In the Hybrid Type 1 trial, 24 autistic adolescents and young adults received STEPS in their communities at a local agency unaffiliated with the research study.

RESULTS

Based on stakeholder input (Phase 1), several adjustments were made to the program prior to implementation (e.g., increased attention to building client motivation, clarification of the role of caregivers). Stakeholders and providers indicated that STEPS could be successfully delivered and adopted in the community. From the pilot (Phase 2), results indicate feasibility of study procedures and intervention implementation, supporting future larger scale implementation. Caregiver-rated transition readiness significantly increased from baseline to endpoint, as well as some domains of functional independence (finance management, self-care, engagement in the community). Employment and education status at endpoint did not yield a clear pattern indicating positive or negative impact of the program.

CONCLUSIONS

This pilot study supports the feasibility, acceptability, and effectiveness of STEPS as delivered by community providers.

CLINICALTRIAL

This trial was pre-registered with ClinicalTrials.gov (Identifier NCT05581069).
Tata kelola dokumen kehukuman berbasis pengintegrasian dengan jaringan dokumentasi dan informasi hukum
Authors: Akbar Zulfikar , Prijana Prijana , Rodiah Saleha
Published: December 2024

Introduction. The integration of legal document management at PTKIN with JDIH is necessary to ensure legal certainty. This research aims to describe the process of managing legal documents and information integrated with JDIH within PTKIN.
Data Collection Methods. This research uses qualitative methods with a case study approach. Data collection process were carried out by observations, interviews, and document reviews. There were from informants selected through a purposive approach.
Data Analysis. Data analysis process were carried out by reducing data, presenting data, and conclusions.
Results and Discussion. The management of legal documents at UIN Sunan Gunung Djati Bandung comprises three elements as per Permenkumham RI No.8/2019 and four phases of integration. These phases begin with the preparation of the Terms of Reference for the establishment of the JDIH institution and end with the official release from JDIHN, which is related to the jdih.uinsgd.ac.id website.
Conclusion. The governance of legal documents integrated with JDIH involves three elements: abstracting, processing, and reporting. UIN Sunan Gunung Djati Bandung’s integration with JDIH is considered as a pioneerin Indonesia’s PTKIN scope, making it a reference for other PTKINs in managing legal documents.
Kompetensi pustakawan dalam publikasi karya tulis ilmiah di Forum Perpustakaan Perguruan Tinggi Muhammadiyah ‘Aisyiyah
Authors: Pujiastuti Ana , Zulaikha Sri Rohyanti
Published: December 2024

Introduction. Efforts made to increase the competencies of librarians can be made through the publication of scientific writing. The research aims to determine the competence of librarians in the publication of scientific writing at the Muhammadiyah 'Aisyiyah Higher Education Library Forum Regional Coordinator for the Special Region of Yogyakarta-South Central Java (FPPTMA Regional Coordinator DIY-South Java).
Research methods. This study used a qualitative method, with informants 15 people with snowball sampling. Data collection used observation, in-depth interviews, and documentation. Data analysis techniques use data condensation, data presentation, and drawing conclusions. To test the validity of the data, we used triangulation techniques.
Results and Discussion. Librarians' ability to publish scientific writing is based on their competencies in motive, character, self-concept, knowledge, and skills. The impact of scientific writing publication competency encourages librarians to be productive in producing scientific writing publications which will increase librarian branding.
Conclusion and recommendations. Librarians who have consistent character will produce quality scientific writing. It cannot be separated from communication skills and mastery of scientific writing techniques. This research suggests establishing a regular writing program that can facilitate librarians in their work.
Preservasi pengetahuan lokal mitos di Dusun Kasuran Seyegan Sleman Daerah Istimewa Yogyakarta
Authors: Baroroh Wasilatul
Published: December 2024

Introduction. This study aims to identify efforts to preserve local mythological knowledge in Kasuran Hamlet through exchange of indigenous knowledge, so that local knowledge exists.
Data Collection Methods. The research employs a qualitative method.Data collection involves interviews, observations, and literature reviews.
Data Analysis. The data analysis technique uses the exchange of indigenous knowledge model. The stages of data analysis include data reduction, analysis, and conclusion.
Results and Discussion. Kasuran Hamlet has a unique myth, which is the prohibition of sleeping on a mattress. The community believes that they will get misfortune if they violate the taboo. The preservation of this myth is carried out through the exchange of indigenous knowledge, including: 1) recognizing and identifying myths; 2) validating the authenticity and distinctiveness of myths; 3) recording and documentation as information products; 4) storage for easy access; 5) transfer of knowledge; and 6) dissemination of knowledge to individuals and communities.
Conclusion. The efforts to preserve local mythological knowledge in Dusun Kasuran through exchange of indigenous knowledge have effectively maintained local traditions. The involvement of the community, government, and researchers strengthens the existence of myths in Kasuran Hamlet as an identity and cultural heritage.
Effects of slow internet on academic library staff productivity and job satisfaction
Authors: Durodolu Oluwole O. , Iroaganachi Mercy A , Otunla Josephine N
Published: December 2024

Introduction. This paper investigated the effects of slow internet on academic library staff productivity and job satisfaction of academic library staff using the University of Ibadan library as a case in focus.
Data Collection Methods. The study employed a qualitative research method, guided by a phenomenological research paradigm, using Focus Group discussions for data collection. The responses were presented and discussed objectively.
Data Analysis. NVivo software was used for qualitative data analysis to enhance the depth of qualitative research by providing data management technique and facilitate complex analyses, and support robust reporting.
Results and Discussion. Findings of the study revealed that slow internet may have serious consequences on library staff, their operations, and productivity including; decreased output, staff dissatisfaction, and hampered user services etcetera. The study recommends that universities and library management invest in faster, more reliable internet, implement hybrid systems to provide alternative resources during technological limitations, ensure librarians are adaptable in managing slow internet challenges, and encourage librarians to maintain a positive mindset to avoid frustration and job dissatisfaction.
Conclusion. This research addresses a gap in the literature by examining how internet speed impacts library staff productivity and satisfaction, providing insights for enhancing library services and staff well-being amidst technological challenges.
Kontribusi Taman Bacaan Masyarakat “Pondok Baca Puspita” di Kabupaten Wonosobo sebagai fasilitator belajar anak usia sekolah dasar
Authors: Rahmah Tadzqiya Aulia , Ganggi Roro Isyawati Permata
Published: December 2024

Introduction. The people of Candi Hamlet, Wonosobo, are limited in accessing local libraries due to several factors. TBM “Pondok Baca Puspita” eventually became the strong foundation of the community in fulfilling information needs. This study discusses the contribution of TBM “Pondok Baca Puspita” as a means of learning for school children.
Data Collection Methods. This is a descriptive qualitative research with the data collection techniques such as  interviews, observation, literature study, and document analysis.
Data Analysis. We used the interactive analysis model by Milles and Huberman's data analysis method. This involves data reduction, data presentation, and conclusion drawing.
Results and Discussion. We identified several challenges in learning activities faced by elementary school-age children in Candi Hamlet, Wonosobo. They were low motivation to learn, economic limitations, and limited means of technology-based learning fulfillment. The contribution of TBM in providing learning facilities is shown  in the Sedekah Ilmu Program, as a learning concept, which is a form of non-physical contribution. The provision of mobile phone was to assist in terms of physical contribution. TBM “Pondok Baca Puspita” collaborate  with several parties to improve the  services.
Conclusion. TBM “Pondok Baca Puspita” contributes physically and non-physically  in providing learning facilities for elementary school children in Candi Hamlet, Wonosobo.
Transformation of District/City Response Patterns for Child Protection during Post Covid-19, Case Study of Central Java Province, Indonesia
Authors: Wijaya M. Indra Hadi , Agushybana Farid , Jati Sutopo Patria , Ariani Nofa Martina , Purnami Cahya Tri , Salma Salma , Lisnawati Naintina , Rahman Amni Zarkasyi , Imawan Satria Aji
Published: December 2024

Covid-19 for three years has become an inseparable part of the lives of urban and rural communities. The impact occurs, such as the impact of Covid-19 on children. Children are a vulnerable part of society during a pandemic, about the conditions for their health, education, and protection. The role of the city in carrying out its duties as a public servant is important, where all stakeholders have an important role. Central Java, one of the provinces affected by Covid-19 has responded well with its adaptive programs. This research was conducted with a quantitative approach with a quantitative descriptive method, starting with an analysis of the role of stakeholders and programs related to Covid-19 prevention for children. The results of the analysis are continued by looking at the spatial pattern between cities and districts. Research data is taken from primary surveys through FGD and document review. The results of the study identify that not all city/district areas have a response to child protection during the Covid-19 pandemic, urban areas are more responsive to this condition. Increasing the role of protection for children during a pandemic is an important part of the process of returning to the new normal.
Youth Leadership Development through the Patriot Desa Program of West Java
Authors: Azmi Asraar Kamal , Ikhwan Hakimul , Listyaningsih Umi
Published: December 2024

The national Youth Development Index (YDI) is still fluctuating. One of the provinces with a lower percentage change in YDI than expected is West Java, which is at the bottom of the list. This is ironic considering that 20% of Indonesia's total youth reside in West Java. In fact, during period 2018-2023, many programs were launched which focused on youth development, such as Patriot Desa. The presence of the Patriot Desa Program did not make the value of Youth Participation and Leadership increase. Therefore, this research aims to find out how the Patriot Desa Program impacts youth leadership development in West Java. The methodology used in this research is qualitative with a case study approach. The research was conducted in Sukaharja and Sukamakmur Village, Sukamakmur Sub-district, Bogor Regency. Data collection techniques through interviews the representatives of the West Java DPMD, Patriot Desa, village secretaries, youth organizations, and local champions. The program followed by young people who became Patriot Desas was able to have an impact on the development of individual and social leadership. In particular, the village patriots who served in the research locations were highly dedicated with a self-sacrificing attitude and always collaborated with various parties, so that they were able to bring about changes in the village in social, economic and environmental aspects. However, these things are also inseparable from the influence of pre-deployment orientation and the role of the regional coordinator who is very supportive as a mentor. Youth involvement in community empowerment programs can be a means of developing youth leadership. Therefore, the government needs to involve more youth in other programs so that there is an increase in the domain value of youth participation and leadership.
The Impact of the Confucian Analects on the Concept of Filial Piety in Qutadgu Bilig through the Introduction to the Western Regions of China
Authors: NUERMAMATE Xarwana
Published: December 2024

Since ancient times, filial piety has been a traditional virtue of the Chinese people, highly regarded and praised by numerous scholars and sages. This paper intends to conduct an in-depth study of the influence of The Confucian Analects, which was introduced to the Western Regions of China during the Han Dynasty, on the concept of filial piety in Qutadgu Bilig, a work completed during the Song Dynasty, using literature review and textual analysis methods. The research findings reveal that these two works, written in different regions, by different authors, and in different eras, demonstrate significant commonalities in their views on filial piety). Specifically, both works assert that: (1) while parents are alive, one should support and show filial respect to them; after their death, one should bury and offer sacrifices to them with proper rites; (2) children should honor their parents with respect and offer sincere advice when necessary; (3) when away from home, one should show brotherly love, universal compassion, and treat others with kindness; (4) filial piety is used to promote loyalty, and the principle of filial piety is applied to govern society. Additionally, this paper explores the cultural background that explains the commonalities in filial piety found in both works, summarizing them as: Qutadgu Bilig’s recognition and assimilation of Central Plains culture, the deep-rooted acceptance of the concept of filial piety in the Western Regions, and the widespread dissemination of The Confucian Analects in the region.
Интравитальная микроскопия – ​окно в мир биопроцессов
Authors: Степанов М.Е. , Власов А.А. , Демина П.А. , Акасов Р.А. , Бабаева Г. , Юсупов В.И. , Егорова Т.В. , Каримуллин К.Р. , Генералова А.Н. , Наумов А.В. , Хайдуков Е.В.
Published: December 2024

В статье показан потенциал практического
использования метода оптической
микроскопии дорсальной кожной
складки в качестве эффективной
технологии диагностики живых систем.
Экспериментально доказано, что даже
в базовой постановке представленный метод
позволяет получать большой объем полезных
исследовательских данных в условиях,
максимально приближенных к нативным.
SANATÇI ANLATIMINDA İKLİM DEĞİŞİKLİĞİNE YÖNELİK TUTUMUNA İLİŞKİN DİSİPLİNLERARASI SANAT ESERLERİNİN EKOLOJİK AÇIDAN ÇÖZÜMLENMESİ
Authors: Aladağ Erkan , Gültekin Tuba
Published: December 2024

Buzul çağının sona ermesinden günümüze kadar olan süreci uzmanlar, Holosen çağı olarak adlandırmışlardır. Holosen çağı terimi dünyanın buzullar arası yaşanan dönemi betimlemek için kullanmıştır. Holosen çağı ile insanoğlunun yeryüzündeki etkisi artmaya başlamıştır. İnsan var olmak için, doğa ile bir mücadele içerisinde olmuştur. Sanayi Devrimi, kapitalizmin ortaya çıkışı, sömürgecilik, I-II. Dünya Savaşları gibi önemli olaylar nedeniyle doğanın insan eliyle değiştirilmesi hızlanmıştır. Bu kontrolsüz değişim tüm canlıları olumsuz etkilemiştir. Bilim adamları yaşadığımız dönemi ise Antroposen dönemi olarak sınıflandırmıştır. Ekolojik felaketlerle ilgili görsel çalışmalar her dönem sanatçıların ilgisini çekmiştir. Antroposen dönemde yaşanan iklim değişimine bağlı ekolojik felaketlere dair bilinçli ve kolektif çalışmalar, 1960’lı yıllardan sonra ağırlık kazanmıştır. Bu araştırmada özellikle iklim değişikliği problemine ilişkin ana hatlar ele alınmıştır. Araştırmada günümüzde birçok etkinliğe dahil olan ve farklı teknikleri kullanan Joaquin Fargas, Julian Perry ve Michael Pinsky isimli sanatçıların iklim değişikliğine dair çalışmaları incelenmiştir. Sanatçıların eserlerinde kullandığı, gösterdiği imgelerin analizi yapılmıştır. Aynı zamanda sanat dünyasının iklim değişikliğine yönelik tutumu ve bu hayati kriz karşısında neler yapabileceğine dair bulgular da araştırma da gündeme getirilmiştir. Araştırmada nitel araştırma tekniklerinden doküman analizi kullanılmıştır. Araştırma da literatür taraması ve sanatçılarla yapılan röportajlar kullanıldığından, doküman analizi tercih sebebidir. Bu araştırmada elde edilen veriler iklim değişikliği ve disiplinlerarası sanat eserleri ile ilişkilendirilerek sanatçı tutumunun söylemi çözümlenmiştir.
BİREYSEL SES EĞİTİMİ DERSİ ÖĞRETİM PROGRAMI ESER REPERTUVARININ MUTASYON DÖNEMİ ÖĞRENCİLERİNE UYGUNLUĞUN BELİRLENMESİ VE ÖĞRETİM MODELİ REPERTUVAR ÖNERİSİ
Authors: Şenduran Fatma Münevver , Bal Erol
Published: December 2024

Bireysel ses eğitimi, öğrencinin bireysel ses özellikleri ile ses sahasını göz önünde bulundurarak, kazandırılması hedeflenen davranışlara odaklanan bir süreçtir. Ses değişimi, mutasyon dönemindeki çocukların eğitimi açısından konuşma ve şarkı söylemeleri için son derece önemli ve dikkat edilmesi gereken bir dönemdir. Öğrenciler mutasyon aşamasında olduklarından dolayı, seslerinde yaşanan değişimden kaynaklı olarak ses hâkimiyeti kurmakta zorlanmaktadırlar. Güzel Sanatlar Liselerinde öğrenim gören 9. ve 10. sınıf öğrencilerinin mutasyon döneminde olmaları, öğrenim programında kullanılan eserlere uyumlarını da zorlaştırmaktadır. Bu bağlamda mutasyon dönemi öğrencilerinin ses sınırlarını aşan eserleri zamanı gelmeden öğrenmeleri ses sağlığı açısından oldukça zararlıdır. Bu düşüncelerden hareketle, BSE Öğretim Programı 2019 ve 2023 baskılı ders kitaplarında yer alan 59 eser; türleri, ses sahaları, usûl/ölçü yapıları gibi parametreler incelenecektir. Ardından dersi alan öğrencilerin ses aralıklarının 1. oktav Do ve Si ses aralığında olduğu dikkate alınarak incelenen 59 eserin öğrencilerin ses sahasına uygun olup olmadığı değerlendirilmiştir. Elde edilen bulgular doğrultusunda, kullanılan eser repertuvarının, ses aralıklarının genellikle öğrenciler için uygun olmadığı, tiz(ince) olduğu tespit edilmiştir. Müfredatta yer alan eserlerin mevcut ses sahasının, sonradan öğrencilerin ses sağlığı ile ilgili ciddi sorunlar ortaya çıkarma ihtimali araştırmanın önemini ortaya koymaktadır. Çalışma bu bağlamda öğrencilerin ses aralıklarına yönelik olarak tespit edilecek eserler ve müfredat belirlenmesi açısından da önem arz etmektedir.
ELAZIĞ DEVLET KLASİK TÜRK MÜZİĞİ VE KÜRSÜBAŞI TOPLULUĞUNUN YÖRE MÜZİĞİNE VE KÜLTÜRÜNE KATKILARI
Authors: Yıldırım Adem , Karaburun Doğan Derya
Published: December 2024

Elazığ ili binlerce yıldır farklı kültür ve medeniyetlerin bir arada yaşadığı kadim kentlerden biridir. Bu heterojen yapı içerisinde yörenin müziği de oldukça zengin yapı ve melodiye sahiptir. Elazığ Devlet Klasik Türk Müziği ve Kürsübaşı topluluğu bu zengin kültürün gelecek kuşaklara aktarılmasında etkin rol almıştır. Araştırmada ‘Nitel Araştırma’ yöntemi kullanılmıştır. En başta kaynak taraması yapılmış olup sonrasında yapılan mülakat sonucunda Elazığ Devlet Klasik Türk Müziği ve Kürsübaşı topluluğunun yapmış olduğu konserlerin ve turnelerin yörenin müziğini tanıtmada ne derecede etki ettiği, yörenin kültürü ve müziğinin gelişiminde ki rolü konusunda yanıtlar aranmıştır. Bu çalışmada söz konusu kurumun özellikle Elazığ yöre müziği etkinliklerine, yurtiçi turnelerinde yapılan etkinliklere, konserlere yer verilmiştir. Yapılan bu etkinliklerin yöre müziğinin gelişimine yöre kültürünün tanınmasına ve gelecek kuşaklara aktarılmasına öncülük etmesi bakımından önem arz etmektedir. Kullanılan yöntem doğrultusunda Elazığ Devlet Klasik Türk Müziği ve Kürsübaşı topluluğunun yörenin kültürel yapısının ve yöresel müziğinin gelişimine, aktarılmasına yapılan konserler ve turneler dolayısıyla Elazığ’ın zengin müzik kültürünün tanıtılmasına katkı sağladığı sonucuna ulaşılmıştır.
The Relational Approach to Causation
Authors: White Andrea
Published: December 2024

Chapter 3 explains what a relational approach to causation is and shows that the relational approach to causation is a substantive philosophical position, and not merely a harmless background assumption or pre-theoretical notion as philosophers of mind have often assumed.
Causal Explanations
Authors: White Andrea
Published: December 2024

Chapter 7 argues that it is not necessary for an explanation to be causal that its explanandum designate an effect and its explanans designate an item that is the cause of that effect. The non-relational theory of causation proposed in chapter 6 implies that facts about causal relations are not the only causal facts that causal explanations could answer to. It is suggested that some causal explanations are made true by the non-relational aspect of causal reality, that is, by facts about substances engaging in processes.
Private Equity Fund Reporting Quality, External Monitors, and Third-Party Service Providers
Authors: Easton Peter D. , Larocque Stephannie A. , Mason Paul , Utke Steven
Published: December 2024

We describe variation in the reporting quality (i.e., accuracy and bias of reported net asset values (NAVs)) of private equity (PE) funds across types of external monitors (investors and auditors) and third-party service providers (valuation specialists, marketers, and administrators). In contrast to public markets, we find only limited evidence that reporting quality varies with the composition and types of investors in PE funds. We observe, however, that reporting quality varies with auditor involvement and the use of third-party service providers; these associations often differ across buyout (BO) and venture capital (VC) funds and from those observed in public markets. Our evidence is important to investors and regulators, especially now that PE supersedes public markets as the main vehicle to raise capital and as regulators increase their focus on private markets.

Data Availability: Data used in this study are available from public sources listed in the paper.

JEL Classifications: G1; G14; G30; M4; M41.
Przeszłość w perspektywie przyszłości w kolekcjach muzealnych Ułan Bator. W stronę nowych znaków tożsamości
Authors: Demski Dagnosław
Published: December 2024

Głównym celem artykułu jest przyjrzenie się miastu Ułan Bator i jego historii w kontekście podstawowych pytań stawianych przez badaczy współczesnych wyzwań Mongolii – stosunku do przeszłości i perspektyw na przyszłość. Znając historię Mongołów oraz ich tradycje nomadyczne, szeroko opisywane także w Polsce, stawiam pytanie, czy miasto pojawia się obok takich znaków mongolskiej tożsamości jak Czyngis-chan, nomadyzm, jurta, konie, a jeśli tak, to w jakich aspektach się to dzieje. Przedmiotem badań są wystawy muzealne z końca 2022 roku. Wybrałam kilka najważniejszych muzeów: Muzeum Czyngis-chana, Muzeum Narodowe, Muzeum Zanabazar i Muzeum Miejskie. Analizuję wystawy i ich przekaz, a przede wszystkim staram się znaleźć odpowiedź na pytanie, czy i w jakiej formie wątki miejskie związane z historią Ułan Bator pojawiają się w przestrzeni publicznej; których muzeów są częścią. Czy możemy dziś przewidzieć, które z tych elementów mają szansę wejść w przyszłości do kanonu tożsamości narodowej? Pytania te są o tyle istotne, że w wyniku gwałtownej migracji mieszkańców do miast w latach 90. ubiegłego wieku ludność stolicy Mongolii stanowi dzisiaj ponad połowę wszystkich obywateli państwa.
Muzeum Alberta Kahna w Paryżu jako wzór muzeum zakorzenionego w mieście
Authors: Stec Barbara
Published: December 2024

W artykule przedstawiono Muzeum Alberta Kahna w Paryżu jako wzór muzeum zakorzenionego w mieście. Określono cechy architektury zakorzenionej, opierając się na idei architektonicznej Kengo Kumy i omówiono Muzeum Alberta Khana w aspekcie tych cech, wskazując powiązania między muzeum jako spójną całością architektury i ogrodów a miastem: jego środowiskiem, dzielnicą Boulogne-Billancourt z jej genius loci, przestrzeniami społeczno-kulturowymi. Tworzą one intensywną i wielostronną sieć relacji, które kształtują współczesny rozwój muzeum, jego architekturę i program.
Arterial liver supply in aspect of right lobe living donor liver transplantation: anatomical variants and reconstruction
Authors: Voskanyan S. E. , Kolyshev I. Yu. , Bashkov A. N. , Artemyev A. I. , Rudakov V. S. , Shabalin M. V. , Popov M. V. , Sushkov A. I. , Vohmyanin G. V.
Published: December 2024

Background. A safe removal of the liver right lobe and restoration of arterial blood supply to the liver graft is possible only with a full understanding of the anatomy of the hepatic artery in a donor.

Objective. To describe new and extend contemporary data on anatomical variations of the arterial blood flow in a donor of the right liver lobe.

Material and methods. From 2009 to 2021, 306 living donor liver transplantations were performed in the State Research Center – Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency. The vascular anatomy of 518 potential donors was analyzed. Hepatic artery anatomical variants of a right lobe graft were assessed.

Results. Eleven types of right lobe arterial supply and 7 subtypes of the arterial anatomy of liver segment 4 were identified. The case rates of types and subtypes where reconstruction could be performed were following: type A, subtypes 1, 2, 3, 4, 5 (57.5%, 26.1%, 5.5%, 1.9%, 0.3%, respectively); type B, subtypes 1, 4, 5 (0.3% each); type С, subtypes 1, 2 (2.9%, 1.3%, respectively); type D, subtypes 1, 3 (0.3% each); type Е subtype 1 (0.6%), types F-J subtype 1 (0.3% each). Liver right lobe harvesting and arterial reconstructions were fully performed in all types and subtypes excluding anatomical type K, subtype 7. Arterial postoperative complications (11 cases) were detected in 3.5% observed cases of 306 transplants and in 5.9% of all patients with complications (184). Mortality rate due to arterial complications was 1.9% (6 cases).

Conclusion. The existing classification of right liver graft hepatic artery anatomy was updated and detailed regarding the applicability in right lobe liver transplant. The arterial anatomy of right lobe liver graft shows great variability and complexity for systematization and thus may need further studies.
The debut of benign recurrent intrahepatic cholestasis in acute hepatitis A
Authors: Kokina K. Yu. , Malinovskaya Yu. O. , Sumtsova O. V. , Grigorevskaya A. O. , Moysyuk Ya. G.
Published: December 2024

Background. Benign recurrent intrahepatic cholestasis is a rare inherited disorder characterized by recurrent episodes of severe hyperbilirubinemia and pruritus that resolve spontaneously. However, attacks of cholestasis may persist for several months and in some cases be associated with frequent recurrences, which may be grounds for liver transplantation.

Objective. To present a clinical case of debut benign recurrent intrahepatic cholestasis following acute hepatitis A.

Results. A 30-year-old patient was admitted at the Liver Transplantation Center of Moscow Regional Research and Clinical Institute n.a. M.F. Vladimirskiy for a prolonged episode of intrahepatic cholestasis with severe coagulopathy after acute hepatitis A. Total bilirubin was elevated up to 835 µmol/L and INR was 3.6. The manifestations of vitamin K-associated coagulopathy were controlled after the first dose of parenteral menadione sodium bisulfite. Glucocorticosteroids, ursodeoxycholic acid and plasmapheresis turned ineffective in the treatment of hyperbilirubinemia. Due to long-persisting cholestasis resistant to conservative therapy, the patient was considered for inclusion to the liver transplant waiting list. However, spontaneous resolution of the cholestatic episode was achieved at 5 months after the onset of manifestations. Benign recurrent intrahepatic cholestasis type 2 was diagnosed on the basis of the specific clinical signs, laboratory blood tests and genetic testing.

Conclusion. The present Case Report shows a long-lasting episode of cholestasis with severe coagulopathy in acute hepatitis A in a patient with benign recurrent intrahepatic cholestasis with subsequent spontaneous resolution of the clinical symptoms at 5 months after their manifestation onset. Therefore, the differential diagnosis of benign recurrent intrahepatic cholestasis should be considered prior to liver transplantation in patients with intrahepatic cholestasis.
The experience of bilateral lung retransplantation after prolonged extracorporeal oxygenation
Authors: Tarabrin E. A. , Khubutiya M. Sh. , Guseva A. S. , Ermakova E. A. , Pervakova E. I. , Zhuravel S. V. , Gasanov A. M. , Kotandzhyan V. G. , Karchevskaya N. A. , Kallagov T. E. , Ibavov I. U. , Kevorkova M. S. , Berikkhanov Z. G. , Ivanova M. Yu.
Published: December 2024

Background. Transplantation is the only effective method of helping patients with irreversible damage of the lung function when the possibilities of other treatment methods have been exhausted. At the same time, a chronic graft rejection is the main cause of the loss of the donor organ function in the long-term period, developing in more than 50% of patients within 5 years after surgery. Given irreversible lung damage with loss of lung functions, the only effective treatment method for this patient population is retransplantation, which is associated with high risks of complications and a long rehabilitation of the patient in the postoperative period.

Objective. Demonstration of the first Russian experience of bilateral lung retransplantation in a patient after a longterm extracorporeal oxygenation.

Results. The article presents the description of the first experience of bilateral lung retransplantation in Russia performed in a patient with a chronic rejection 4.5 years after the primary transplantation performed for end-stage lung lesions in non-langerhans cell histiocytosis. In the 96-day period of waiting for a donor organ, the patient's gas-exchange lung function was compensated by using veno-venous extracorporeal membrane oxygenation.

Conclusions. Retransplantation is an effective method of treatment for patients with irreversibly damaged lung function, but still remains an operation associated with high risks of complications and unfavorable outcome.
Treatment of splenic artery aneurysms of patients with cirrhosis in the Waiting list
Authors: Bagateliya Z. A. , Drozdov P. A. , Astapovich S. A. , Lidzhieva E. A. , Alieva F. F. , Shabunin A. V.
Published: December 2024

Objective. The aim of our work was to evaluate the immediate and remote results of ligation of splenic artery aneurysm in orthotopic liver transplantation in patients with decompensated liver cirrhosis.

Material and methods. From June 2018 to May 2024, 232 liver transplants from a posthumous donor were performed at the Surgical Clinic of the Moscow Multidisciplinary Scientific and Clinical Center n.a. S.P. Botkin. In 4 patients (1.7%), the presence of aneurysmal dilatation of the splenic artery was revealed at the preoperative stage. During orthotopic liver transplantation, patients underwent ligation of the splenic artery proximal and distal to the aneurysms.

Results. Mean time for the isolation and ligation of the splenic artery aneurysm was 18.4±3.3 minutes. In no case was there any damage or bleeding from either the branches or the aneurysm of the splenic artery; and there was no damage to the spleen. No adverse events related to the splenic artery aneurysm ligation were recorded in either early or late postoperative periods. In all cases, the control examination did not reveal any ischemic changes in the splenic parenchyma.

Conclusion. Ligation of the splenic artery aneurysm during orthotopic liver transplantation is a safe, effective and necessary surgical intervention that can improve long-term results by reducing the risk of death from aneurysm rupture in the postoperative period.
Non-invasive predictors of the first episode of bleeding from esophageal varices in patients with liver cirrhosis awaiting transplantation
Authors: Korobka V. L. , Khoronko Yu. V. , Pasechnikov V. D. , Korobka R. V. , Malevanny M. V. , Pak E. S. , Pasechnikov D. V.
Published: December 2024

Background. To date, various non-invasive techniques or tests have been proposed that can identify a high risk of bleeding from esophageal varices. Despite a significant number of studies revealing the presence of venous varices as a likely factor for the development of bleeding due to their rupture, data on predictors of the first episode of bleeding are few and often contradictory.

Objective. To determine non-invasive independent predictors of the first episode of bleeding in patients waiting for liver transplantation.

Material and methods. A comparative retrospective study was conducted in 729 patients with decompensated cirrhosis who were on the waiting list for liver transplantation. We analyzed demographic, clinical and laboratory parameters, MELD-Na, Child-Turcotte-Pugh scores, FIB-4 Index, APRI, AST/ALT ratio; we determined the liver stiffness, spleen diameter, studied the liver stiffness-spleen diameter to platelet ratio risk score (LSPS model), platelet count/spleen diameter ratio in the groups of patients with the first episode of bleeding (n=334) and without it (n=395). The accumulated risks in the compared groups were assessed using a model of proportional hazards (Cox regression) in univariate and multivariate analysis.

Results. During 48 months of follow-up from the time of patient placement on the liver transplant waiting list, primary bleeding events developed in 45.8%. The risk of developing the first episode of bleeding progressively increased with LSPS >3.5 and reached maximum values in patients awaiting liver transplantation within 48 months of inclusion in the waiting list, while with LSPS <3.5 the risk was minimal.

Conclusion. Independent non-invasive predictors of the first episode of bleeding are a high level of AST, a high fibrosis index (FIB-4), a decrease in the ratio of platelet count/spleen diameter and a high LSPS value. Their application in clinical practice will improve the results of dispensary and screening examinations of patients with portal hypertension.
"É só aplicar a fórmula: Δ = b2 - 4ac"
Authors: Ciríaco Klinger Teodoro , Morelatti Maria Raquel Miotto , Ponte João Pedro da
Published: December 2024

O artigo explora interações produzidas numa experiência de trabalho colaborativo com professoras iniciantes, a qual foi objeto de doutoramento do primeiro autor, sob orientação da segunda autora e coorientação do exterior realizada pelo terceiro autor. Objetivamos compreender que aprendizagens são propiciadas via compartilhamento de práticas profissionais por meio da videogravação de aulas de Matemática. O referencial teórico destaca perspectivas do desenvolvimento profissional, características da fase de indução à docência e aspectos da colaboração. A metodologia adotada foi a pesquisa-ação estratégica, mediada pela negociação de significados da constituição da prática pedagógica. Os resultados implicam reconhecer a necessidade de investimento em estudos propositivos, nos quais professores assumem o papel de protagonistas de sua aprendizagem na busca do desenvolvimento profissional.
Traduções do discurso curricular oficial para o contexto da prática
Authors: Neira Marcos Garcia
Published: December 2024

O presente artigo objetivou compreender como os professores de Educação Física que participaram dos cursos de formação voltados à implementação da política curricular municipal traduzem para a prática o discurso materializado no documento oficial. Para tanto, foram produzidos relatos de experiência a partir de entrevistas com os participantes que afirmam colocar em ação a proposta. Ancoradas no referencial teórico pós-estruturalista, as narrativas docentes foram confrontadas com os argumentos que sustentam o discurso oficial. Inferiu-se que a preocupação dos educadores se volta às questões metodológicas. A ênfase dada ao saber como fazer, em vez de uma apropriação crítica da epistemologia que subsidia a política curricular em questão, configura uma visão reducionista, ao que tudo indica, decorrente do modo de condução das ações formativas.
Constructos teóricos de Tall para o ensino de derivada
Authors: Almeida Marcio Vieira , Igliori Sonia Barbosa Camargo
Published: December 2024

Este artigo se propõe a contribuir com a discussão deste número da revista EMP em torno da questão “Como desenvolver um Modelo de Referência Epistemológico (MER) para o ensino de Cálculo?”, considerando especificamente o ensino da derivada. Os argumentos aqui expostos norteiam-se pela defesa da inclusão de constructos teóricos, como os desenvolvidos por Tall para o ensino de derivada, pelas potencialidades que eles têm de agregar contribuições de ordem cognitiva e didática aos aprendizes e aos professores respectivamente. Os constructos aos quais nos referimos foram denominados por Tall por organizador genérico e a raiz cognitiva da retidão local. Para os autores deste texto a inclusão desses constructos, em um MER, pode favorecer a integração teoria e prática importante ao desenvolvimento do ensino da Matemática. Organizamos as reflexões encadeando ideias sobre: integração teoria e prática; concepção de um MER; ensino da derivada e os construtos teóricos de Tall. Finalizamos a apresentação do artigo reforçando a importância da vigilância sobre a epistemologia dominante do conceito de derivada para o ensino, com vista à busca de contribuições à emancipação da Didática da Matemática com o favorecimento do ensino do Cálculo.
Modelo epistemológico de referência na teoria antropológica do didático
Authors: Ignácio Renato da Silva , Santos Júnior Valdir Bezerra dos , Dias Marlene Alves
Published: December 2024

Este artigo é um recorte de uma pesquisa de doutorado que investigou os limites e possibilidades da metodologia didática percurso de estudo e pesquisa (PEP), da teoria antropológica do didático (TAD), como alternativa de ensino para a educação básica do Brasil. Iniciamos a pesquisa considerando a pergunta: Como encontrar o menor percurso possível interligando uma origem (O) e um destino (D)? Este problema nos conduziu a considerar a elaboração do que na TAD se denomina modelo epistemológico de referência (MER). O MER é o modelo que precisa ser explicitado toda vez que se deseja formular um autêntico problema didático ou questão geradora de estudo. Este trabalho apresenta, inicialmente um comparativo da modelagem entre a TAD e outras correntes teóricas, e em seguida um exemplo de modelo epistemológico de referência a partir do problema da escolha do caminho mais curto de acesso de um ponto a outro sobre determinadas condições. Consideramos como objetivo deste artigo relacionar, por meio da noção de praxeologia, a possibilidade de uma modelagem sob a luz da TAD. O estudo comparativo nos mostra que a modelagem no escopo da TAD não é um objeto a ser ensinado e nem um meio para aprender e ensinar certos conceitos matemáticos. A principal característica da modelagem na TAD consiste na elaboração e contraste experimental de modelos epistemológicos de matemática com a finalidade de abordar problemas didáticos como uma hipótese provisória, que pode ser modificada durante o processo de desenvolvimento de um PEP.
Prolégomènes pour la construction d'un modèle épistémologique de référence pour l'enseignement du calcul
Authors: Teixeira Bartira Fernandes , Carvalho Edmo Fernandes , Farias Luiz Marcio Santos
Published: December 2024

Este artigo propõe uma reflexão teórica sobre o que são modelos e o que é Cálculo, apontando noções preliminares e princípios básicos para que se possa construir um modelo epistemológico de referência para o ensino desta disciplina. Para atingir esse objetivo, examinamos alguns modelos presentes no nosso cotidiano, numa tentativa de sugerir uma generalização do termo. A seguir, apresentamos o modelo representativo proposto pela teoria antropológica do didático, para, posteriormente, definir modelo epistemológico dominante, modelo epistemológico de referência e modelo didático de referência. Ultrapassadas essas definições, desenvolvemos uma breve história do termo para esclarecer o que entendemos hoje por Cálculo e como foi utilizado ao longo do tempo. Os resultados da pesquisa teórico-bibliográfica serão úteis para que os pesquisadores em didática possam construir um modelo epistemológico de referência para o ensino do Cálculo.
discussão sobre a definição de limite de uma sequência
Authors: Monteiro da Silva Burigato Sonia Maria , Aniz Claudemir , Milena Ramos Carvalho Lilian
Published: December 2024

Neste artigo apresentamos um estudo sobre dificuldades no processo de aprendizagem da definição de limite de uma sequência. É uma pesquisa qualitativa cujo objetivo foi analisar as ações de um sujeito ao lidar com uma situação envolvendo essa definição. Para isso, trouxemos uma discussão sobre os conceitos envolvidos no campo conceitual dessa definição, juntamente com a análise de uma situação proposta. Os dados foram produzidos por meio da produção escrita e oral, coletada pelas folhas de resolução da atividade e por áudio e vídeo produzidos durante a sessão realizada. As análises evidenciam a dificuldade em se desvincular de representações gráficas mobilizadas para tratar situações particulares, no caso de sequências que convergem, mesmo quando o sujeito é confrontado com estudo dos elementos conceituais envolvidos na definição formal.
Integração de abordagens pragmáticas e dedutivas no ensino de limites
Authors: Neves Anderson Souza , Burigato Sonia Maria Monteiro da Silva , Farias Luiz Márcio Santos
Published: December 2024

Este estudo investiga a construção do conceito de limite de função, um desafio central no ensino de cálculo e análise. Utilizando duas pesquisas empíricas, uma finalizada, com base na teoria dos campos conceituais, e outra em andamento, fundamentada na teoria antropológica do didático, desenvolvemos tarefas que visam integrar modelos epistemológicos pragmáticos e dedutivos. Os resultados preliminares sugerem que essa integração pode minimizar as dificuldades de compreensão dos alunos e reduzir a fragmentação do conhecimento científico na área. Concluímos que a aplicação dessas abordagens teóricas proporciona uma visão mais coesa e eficaz no ensino de limites de função.
Impacto do Transtorno do Desenvolvimento da Linguagem no Desenvolvimento Infantil
Authors: Alvarenga Fernanda Correia Santos Bahia , Franchi Vanessa Magosso , Pontes Ana Paula Cavalieri , Cavalcanti Gabriela Silva Teixeira , Pena Isamara Simas de Oliveira , Guerra Mônica Elisabeth Simons
Published: December 2024

Introdução: O processamento de linguagem requer ativação de redes neurais complexas que extrapolam as áreas clássicas de tratamento de linguagem no cérebro. Prejuízos nessas redes representam risco significativo para o desenvolvimento da fala e linguagem, podendo resultar em diagnóstico de Transtorno do Desenvolvimento de Linguagem. Objetivo: Relatar o caso de uma criança previamente diagnosticada com Transtorno do Espectro do Autismo que após avaliação foniátrica recebeu diagnóstico de TDL (Transtorno do Desenvolvimento da Linguagem). Relato de caso: Masculino, 5 anos e 7 meses. Relato de comportamento tímido, autoagressão e hipersensibilidade a som e luz. Na avaliação inicial, mostrou-se retraído, porém com intenção comunicativa e reciprocidade nos turnos de comunicação não verbal. Apresentou brincadeira simbólica. Observaram-se alterações significativas nos subsistemas de linguagem receptiva e expressiva. O Teste Denver II revelou atrasos nas áreas pessoal-social, motor fino, além de atraso marcante na linguagem. Com terapia fonoaudiológica obteve melhora. Discussão: A foniatria dedica-se aos distúrbios de fala, linguagem e comunicação, avaliando o desenvolvimento infantil de forma integral. Distúrbios de linguagem têm um impacto profundo ao longo da vida, prejudicando o desenvolvimento social, emocional e educacional, além de aumentar o risco para problemas comportamentais, de saúde mental e dificuldades de emprego na vida adulta. Conclusão: O presente estudo ressalta a importância da avaliação clínica com olhar ampliado aos marcos de desenvolvimento em crianças com TDL, ressaltando que este quadro pode ser acompanhado por atrasos em outros marcos do desenvolvimento extralinguísticos.