bluuebunny/crossref_metadata_2025 huggingface dataset:
Honor, face, and dignity norm endorsement among diverse North American adolescents: Development of a Social Norms Survey
Authors: Frey Karin S. , Onyewuenyi Adaurennaya C. , Hymel Shelley , Gill Randip , Pearson Cynthia R.
Published: September 2020

This article examined the psychometric properties and validity of a new self-report instrument for assessing the social norms that coordinate social relations and define self-worth within three normative systems. A survey that assesses endorsement of honor, face, and dignity norms was evaluated in ethnically diverse adolescent samples in the U.S. (Study 1a) and Canada (Study 2). The internal structure of the survey was consistent with the conceptual framework, but only the honor and face scales were reliable. Honor endorsement was linked to self-reported retaliation, less conciliatory behavior, and high perceived threat. Face endorsement was related to anger suppression, more conciliatory behavior, and, in the U.S., low perceived threat. Study 1b examined identity-relevant emotions and appraisals experienced after retaliation and after calming a victimized peer. Honor norm endorsement predicted pride following revenge, while face endorsement predicted high shame. Adolescents who endorsed honor norms thought that only avenging their peer had been helpful and consistent with the role of good friend, while those who endorsed face norms thought only calming a victimized peer was helpful and indicative of a good friend. Implications for adolescent welfare are discussed.
Loneliness is associated with the subjective evaluation of but not daily dynamics in partner relationships
Authors: Mund Marcus , Weidmann Rebekka , Wrzus Cornelia , Johnson Matthew D. , Bühler Janina Larissa , Burriss Robert Philip , Wünsche Jenna , Grob Alexander
Published: September 2020

Loneliness describes a perceived deficiency in quantitative or qualitative aspects of individuals’ social relationships. Whereas the health-related consequences of loneliness are well-documented, surprisingly little is known about its interpersonal features and its consequences for relationship outcomes. In the present study, we investigated the association between loneliness and relationship experiences in partner relationships with a sample of 937 individuals from 480 mixed-sex couples. By employing actor-partner interdependence models and dyadic cross-lagged moderated multilevel models, we found higher loneliness to be robustly related to (a) lower relationship satisfaction for both oneself and the partner, (b) more self-reported, but not partner-reported conflicts, (c) lower average levels of one’s own, but not the partner’s closeness, and (d) less own self-disclosure. In contrast, loneliness was not associated with (a) sexual contact frequency, (b) average levels of physical affection, or (c) the daily dynamics between closeness and self-disclosure/physical affection. Thus, the results of the present study indicated that loneliness is primarily associated with the perception of the partner relationship but not its rather objective features or daily dynamics.
Eugène Atget and Documentary Photography of the City
Authors: Rizov Vladimir
Published: September 2020

This paper focuses on the documentary photography of Eugène Atget in late 19th and early 20th-century Paris. I will begin by exploring Atget’s position as a pioneering documentary photographer in the field, followed by an engagement with the urban environment of Paris, in which Atget worked almost exclusively. Finally, I will analyse a single photograph in depth while discussing it in relation to the work of Charles Baudelaire and Jacques Rancière. This text is a contribution to a literature of critical engagement with documentary photography, urban history and the politics of class visibility. I will do so by arguing for the political significance of reading Atget’s images in a critical, political manner that engages with Rancière’s concept of the ‘anonymous multiple’. Atget is considered a key documentary photographer, and, as such, he is exemplary of the history of documentary photography and its treatment of its subjects.
Romantic relationships in adults with ADHD: The effect of partner attachment style on relationship quality
Authors: Knies Katherine , Bodalski Elizabeth A. , Flory Kate
Published: September 2020

Prior literature indicates that insecure attachment styles (i.e., anxious or avoidant) and attention-deficit/hyperactivity disorder (ADHD) both have negative impacts on romantic relationships, but relatively little is known about how these factors interact among couples where one partner has ADHD and the other does not. One hundred and fifty-nine partners of adults with significant ADHD symptoms completed measures of their own attachment styles, their partner’s ADHD symptoms, and relationship quality. Anxious attachment was associated with lower romantic relationship quality, but avoidant attachment was associated with more positive relationship outcomes. Results also indicated that the negative effect of ADHD symptoms on romantic relationship quality may be exacerbated by a partner’s high level of anxious attachment. Though insecure attachment styles are generally thought to have a negative impact on romantic relationships, avoidant attachment was generally associated with more positive outcomes in this study. Several possible explanations based on theoretical support are included in the discussion along with clinical applications and future directions.
A proposed redosing interval of del Nido cardioplegia solution in adult cardiac surgery: a propensity-matched study
Authors: Koda Yojiro , Kitahara Hiroto , Nishida Hidefumi , Jeevanandam Valluvan , Ota Takeyoshi
Published: September 2020

Background:

Recently, del Nido cardioplegia solution (DN) has been utilized in adult cardiac surgery. However, adequate interval of maintenance dose(s) is still unclear. The purpose of this study was to assess the safety and efficacy of our DN protocol by comparing with conventional cold whole blood cardioplegia (CWB).

Methods:

A total of 1003 consecutive patients (DN group, N = 350 vs. CWB group, N = 653) underwent cardiovascular surgery between July 2013 and September 2018 were included in this study. The DN protocol was to administer 1000 to 1200 ml as an initial dose and to add maintenance dose(s) (500 ml each) every 60 minutes when the estimated cross-clamp time was over 90 minutes. CWB was given every 20 minutes, regardless of cross-clamp time. Propensity matching identified 254 matched pairs for analysis. The preoperative and postoperative data were reviewed.

Results:

Cross-clamp time was significantly shorter in the DN group compared with the CWB group (107 ± 56 minutes vs. 116 ± 49 minutes, p = 0.0458). A retrograde cannula was used in 124 (48.8%) patients in the DN group and 181 (71.3%) patients in the CWB group (p < 0.0001). There were no significant differences in requiring postoperative cardiac supports (inotropes, mechanical circulatory supports) and major complications. In-hospital mortality was similar between two groups (DN group: 3.2% vs. CWB group: 2.4%, p = 0.5872).

Conclusions:

Short-term clinical outcomes in the patients underwent cardiovascular surgery with the DN protocol including the redosing interval strategy were acceptable. Also, DN protocol was associated with shortened cross-clamp time and less usage of the retrograde cannula.
Trimetazidine can prevent the occurrence of contrast-induced nephropathy after percutaneous coronary intervention in elderly patients with renal insufficiency
Authors: Fu Han , Zhang Jing , Zhang Hong , Zhang Peng , Fu Xiaofeng , Zeng Zhican , Zhang Xue , Li Wenyuan , Yang Shicheng , Liu Xiaogang , Fu Naikuan
Published: September 2020

Background:

Contrast-induced nephropathy (CIN) has become a common cause of hospital-acquired acute kidney injury in elderly patients. Trimetazidine (TMZ) is a type of anti-ischemic drug developed in recent years, which can reduce the incidence of CIN. This study aimed to evaluate the efficacy of TMZ in the prevention of contrast-induced nephropathy in elderly patients with renal insufficiency undergoing percutaneous coronary intervention (PCI) and to explore the mechanism of action.

Methods:

A total of 310 elderly patients with renal insufficiency undergoing elective PCI were enrolled and randomly assigned to a control group (n = 155, hydration only) and a TMZ group (n = 155, 20 mg thrice daily orally 24 hours before and 72 hours after PCI). The primary endpoint of the study was the incidence of CIN, which was defined as an increase of 25% or more, or an absolute increase of 0.5 mg/dL or more in serum creatinine from baseline value, at 48 to 72 hours following the exposure to contrast media (CM).

Results:

The incidence of CIN was significantly lower in the TMZ group than that in the control group (3.2% vs. 9.7%, p = 0.021). There was no difference regarding the incidence of major adverse events during hospitalization between the TMZ group and control group (1.9% vs. 2.6%, p = 1.000). Binary logistic regression results showed that TMZ was protective factors of CIN (OR = 0.274; 95% CI: 0.089–0.847; p = 0.025).

Conclusion:

Therefore, we came to the conclusion that prophylactic administration of TMZ can prevent the occurrence of CIN in elderly patients with renal insufficiency undergoing PCI and has a certain protective effect on the renal function of patients. According to the experimental results and the mechanism of TMZ on cardiomyocytes, we speculate that TMZ increases kidney glucose metabolism, reduces fatty acid oxidation, and also has a protective effect on kidney free radical damage and ischemia-reperfusion injury.
Split renal function after treatment of small renal masses: comparison between radiofrequency ablation and laparoscopic partial nephrectomy
Authors: Acosta Ruiz Vanessa , Båtelsson Sarah , Onkamo Elina , Wernroth Lisa , Nilsson Thomas , Lönnemark Maria , Dahlman Pär , Magnusson Anders
Published: September 2020

Background

Radiofrequency ablation (RFA) and laparoscopic partial nephrectomy (LPN) are used to treat small renal masses (SRM; ≤4 cm), although there are conflicting results in the changes in creatinine and estimated glomerular filtration rate (eGFR) after treatment. On contrast-enhanced computed tomography (CE-CT) images, the quantity and quality of renal function can be evaluated by calculating the split renal function (SRF).

Purpose

To compare renal function after RFA or LPN treatment of SRMs through evaluation of the SRF in the affected kidney.

Material and Methods

Single T1a renal tumors successfully treated with RFA (n = 60) or LPN (n = 31) were retrospectively compared. The SRF was calculated on pre-treatment CE-CT images and the first follow-up exam after completed treatment. Serum creatinine and eGFR values were collected simultaneously. To compare renal function outcomes, Student’s t-test and multivariable linear regression models (adjusted to RFA/LPN treatment, pre-treatment SRF/eGFR, BMI, age, tumor characteristics, and Charlson Comorbidity Index) were used.

Results

SRF was reduced in both groups, although reduction was greater in the LPN group (LPN –5.7%) than in the RFA group (RFA –3.5%; P = 0.013). After adjusted analysis, the LPN group still had greater SRF reduction (difference 3.2%, 95% confidence interval 1.3–1.5; P = 0.001). There was no difference between groups in the change of creatinine/eGFR after treatment.

Conclusion

Both RFA and LPN are nephron-sparing when treating SRMs. However, in this series, reduction of SRF in the affected kidney was smaller after RFA, having a more favorable preservation of renal function than LPN.
Microwave ablation of 105 T1 renal tumors: technique efficacy with a mean follow-up of two years
Authors: Acosta Ruiz Vanessa , Dahlman Pär , Brekkan Einar , Lönnemark Maria , Magnusson Anders
Published: September 2020

Background

Thermal ablation (TA) with radiofrequency (RFA) or cryoablation (CA) are established treatments for small renal masses (≤4 cm). Microwave ablation (MWA) has several potential benefits (decreased ablation time, less susceptibility to heat-sink, higher lesion temperatures than RFA) but is still considered experimental considering the available small-sample studies with short follow-up.

Purpose

To evaluate technique efficacy and complications of our initial experience of renal tumors treated using percutaneous MWA with a curative intent.

Material and Methods

A total of 105 renal tumors (in 93 patients) were treated between April 2014 and August 2017. MWA was performed percutaneously with computed tomography (CT) guidance under conscious sedation (n=82) or full anesthesia. Patients were followed with contrast-enhanced CT scans at six months and yearly thereafter for a minimum of five years. The mean follow-up time was 2.1 years. The percentage of tumors completely ablated in a single session (primary efficacy rate) and those successfully treated after repeat ablation (secondary efficacy rate) were recorded. Patient and tumor characteristics as well as complications were collected retrospectively.

Results

The median patient age was 70 years and median tumor size was 25 mm. Primary efficacy rate was 96.2% (101/105 tumors). After including two residual tumors for a second ablation session, secondary efficacy was 97.1% (102/105). Periprocedural complications were found in 5.2% (5/95) sessions: four Clavien-Dindo I and one Clavien-Dindo IIIa. One postprocedural Clavien-Dindo II complication was found.

Conclusion

MWA has high efficacy rates and few complications compared to other TA methods at a mean follow-up of two years.
Effect of parathyroid hormone-related protein on intracellular calcium ion and cyclic adenosine monophosphate concentrations in cardiac fibroblasts
Authors: Zhou Ping , Xiao Qiong , Su Zhao-Ting , Zhu Lin , Jin Fang-Xia , Du Xuan-Yi
Published: September 2020

Objective

This study aimed to determine the effect of parathyroid hormone-related protein (PTHrP) on proliferation of cardiac fibroblasts (CFs) in primary cultures of neonatal Wistar rats.

Methods

Different PTHrP concentrations were added to CFs of neonatal Wistar rats and the cells were grouped according to the concentrations added. A verapamil (VPL) group and a calcitriol (CAL) group were also established. Changes in cell proliferation and in cyclic adenosine monophosphate and calcium ion levels were identified and recorded.

Results

We found that as the concentration of PTHrP increased, 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT, a tetrazolium salt) colorimetric absorbance values (A values) decreased. These values in the PTHrP groups were significantly lower than those in the control group. MTT colorimetric A values and 3H-thymidine deoxyribose intake were lower in the VPL group, low-dose CAL group, and the PTHrP 10−7 mol/L group compared with the control group. However, MTT colorimetric A values and 3H-thymidine deoxyribose intake were higher in the high-dose CAL group than in the PTHrP 10−7 mol/L group. As PTHrP concentrations increased, intracellular cyclic adenosine monophosphate concentrations also increased.

Conclusion

PTHrp, VPL, and low-dose CAL inhibit proliferation of CFs, while high-dose CAL promotes proliferation of CFs.
Imaging findings of cerebral fat embolism syndrome: a case report
Authors: Wang Yali , Si Zhihua , Han Jingzhe , Cao Shuangqing
Published: September 2020

Cerebral fat embolism (CFE) syndrome is relatively rare in clinical practice. Currently, there is no uniform standard of magnetic resonance imaging for the diagnosis of the disease. In this report, we present head computed tomography and magnetic resonance images (T2-weighted images, fluid-attenuated inversion recovery images, diffusion-weighted images, and susceptibility-weighted images) in a case of CFE. This report explains the imaging characteristics of CFE and improves the clinician’s understanding of this disease and its etiology.
Correlation between level of autophagy and frequency of CD8+ T cells in patients with chronic obstructive pulmonary disease
Authors: Zhuang Hong , Li Na , Chen Sida , Shen Yan , Zhan Wugen , Xu Xiangqun , Zhuo Songming
Published: September 2020

Objective

The pathogenesis of chronic obstructive pulmonary disease (COPD) remains elusive. Here, we assessed the correlation between CD8+ T cell frequencies and autophagy in COPD patients.

Methods

Subjects were divided into three groups (n = 30 patients/group): (1) COPD patients in the stable phase; (2) smokers with normal lung function; and (3) non-smokers with normal lung function. Flow cytometry was used to enumerate CD8+ T cell subsets (CD8+, CD8+ effector, and CD8+ memory T cells) and quantitate T-cell apoptosis. RT-PCR and western blotting were used to measure levels of LC3 and p62.

Results

Frequencies of CD8+ T cell subsets and expression of p62 and LC3 II/I were significantly higher in COPD patients compared with the other two groups, while the rate of apoptosis was lower. In COPD patients, LC3 II/I and p62 expression were positively correlated with CD8+ T cell subset frequencies. Moreover, a significant correlation was observed between LC3 II/I and p62 expression and T cell subset frequencies.

Conclusion

Autophagy level is positively correlated with the frequencies of CD8+ T cells, suggesting that autophagy might be involved in COPD pathogenesis.
Evidence on the trade-off between corporate social responsibility and mergers and acquisitions investment
Authors: Krishnamurti Chandrasekhar , Shams Syed , Chowdhury Hasibul
Published: September 2020

In this article, we investigate whether there is a trade-off between corporate social responsibility (CSR) and mergers and acquisitions (M&A) investments. Consistent with conflict resolution view of stakeholder theory, our results document a negative relationship between CSR scores and M&A activity. We further show that the tendency of CSR firms’ low engagements in M&A investmen ts is valid only for firms with no slack. We also find that firms choosing to trade off pay a lower bid premium to targets to create value for acquiring shareholders. These findings are robust to several alternative proxies and endogeneity tests.

JEL Classification: G32, G34
Atrial septostomy in patients supported with venoarterial extracorporeal membrane oxygenation: Analysis of the IMPACT registry data
Authors: Deshpande Shriprasad R , Kennedy Kevin F , Vincent Robert N , Maher Kevin O
Published: September 2020

Background:

Patients with severe cardiac dysfunction, supported on extra-corporeal membrane oxygenation (ECMO), develop left atrial hypertension and often warrant atrial decompression. The procedural risks and outcomes, however, are not well established. Objective of this study is to understand the utilization, safety, and outcomes of atrial septostomy in children supported on venoarterial ECMO utilizing the IMPACT registry database.

Methods:

Data from 55 independent sites reporting to the registry was used for this descriptive study. Patients supported with cardiac ECMO that underwent percutaneous atrial septostomy (PAS) were included and data analyzed.

Results:

Between 2011 and 2018, 223 patients underwent atrial septostomy and were reported to the registry. Mean age was 4.65 years with 52% being males. Diagnoses of heart failure, sepsis, arrhythmia, and renal insufficiency were commonly noted prior to ECMO. The procedure was performed urgently or emergently in most cases (80%). PAS was associated with significant procedural complications such as arrhythmia (6.8%), tamponade (5.4%), and unplanned surgery (3.6%) but no procedural mortality. Overall hospital mortality was 46% (103/223) with 46 of these deaths occurring within 7 days of procedure. Regression analysis showed that African American race (vs Caucasian), race other than Caucasian, chronic lung disease and emergent procedure need were significantly associated with early post-procedural mortality (all p < 0.05).

Conclusion:

Using a large multicenter cardiac catheterization registry, we found that left atrial decompression can be performed without procedural mortality but is associated with significant morbidity. Impact of race, chronic lung disease and procedural urgency on early mortality warrant further studies.
Analysis of rejects from waste printed circuit board processing as an alternative fuel for the cement industry
Authors: Kumar Amit , Holuszko Maria E , Janke Travis
Published: September 2020

Waste Printed circuit boards (PCBs) are one of the most valuable and recycled components of electronic waste due to the presence of precious metals such as copper, silver, gold and palladium. The rejects of the PCB recycling process, named non-metal fraction (NMF) have continuously been sent to landfills. Several researchers have proposed alternative use of NMF as secondary materials such as fillers in composites or as adsorbent. This study is focused on the potential application of the PCB recycling rejects as waste-derived fuel or alternative fuel in the cement industry. Approximately 2 million metric tonnes (Mt) of this waste was produced in 2014 globally and estimated to reach 6.5 million Mt in 2050. The presence of high organic matter in the NMF renders it useful as an alternative fuel. The organic content of the NMF could also potentially be increased using gravity separation and thus increasing its net calorific value. The study showed that the NMF could provide up to 21 MJ kg-1 of heating value with low heavy metal and ash concentration. A comparison with other waste-derived fuel sources is also presented in the paper.
Management of the biodegradable fraction of residual waste by bioreactor landfill
Authors: Di Maria Francesco , El-Hoz Mervat
Published: September 2020

The performances of an integrated system based on mechanical biological treatment and bioreactor landfill with leachate recirculation for managing the mixed municipal solid waste generated in a given Italian district were investigated. In the mechanical biological treatment the municipal solid waste was mechanically sorted into two main streams: a dry and a mechanically sorted organic fraction consisting of 45,000 tonnes year−1. After being sorted the mechanically sorted organic fraction was aerobically pretreated before being disposed of in the 450,000 m3 bioreactor landfill. Experimental runs showed that an aerobic pretreatment period ranging from 15 to 30 days was able to maximize the methane generated by the mechanically sorted organic fraction once landfilled up to 10 Nm3 tonne−1. The aerobic pretreatment leads to a significant volatile solids reduction in the first 30 days, after which the volatile solids concentration remained quite constant. Similarly the potential dynamic respirometer index was significantly reduced in the first 15 days of the aerobic pretreatment decreasing from about 5,000 to about 3,500 mgO2kgVS−1h−1. The whole amount of electrical energy producible by the landfill ranged from 18.5 kWh tonne−1 to 21 kWh tonne−1, depending on the strategies adopted for the activation in bioreactor mode of each landfill cell by the leachate recirculation.
Tweeting in the midst of disaster: A comparative case study of journalists’ practices following four crises
Authors: Hinsley Amber , Lee Hyunmin
Published: September 2020

This comparative case study examines how local journalists used Twitter as a crisis communication tool during four emergency situations in the United States. The public’s retweeting and liking patterns also identified messages that resonated with them. A content analysis found that although local journalists used objective reporting most frequently across all crises, there were variances in Twitter practices of journalists covering the two human-made crises. The two natural disasters showed more similarities. These findings can help develop best-practices strategies for journalists as they cover different types of crises.
Assessment of work-related symptoms, perceived knowledge, and attitude among nail salon technicians
Authors: Lteif Maria , El Hayek Marylene Samia , Azouri Hayat , Antonios Diane
Published: September 2020

Objectives:

Beauty is a Lebanese stereotype, as Lebanese women often feel urged to decorate themselves. Recent studies have raised concerns about nail salon technicians’ (NSTs) health and safety issues. The aim of our study was to evaluate the occupational symptoms reported by NSTs, to assess their knowledge and document their awareness regarding hazardous chemicals found in nail cosmetics.

Methods:

NSTs completed a researcher-administered questionnaire. Data were gathered on sociodemographic characteristics, perceived knowledge, and safety issues. Work-related symptoms reported by NSTs were evaluated, and their responses were compared to those of the office employees.

Results:

A total of 120 NSTs and 120 office employees were interviewed. Compared to the control group, NSTs reported a higher prevalence of work-related respiratory, dermal, and irritative symptoms, all significantly associated with smoking and a poor ventilation system. In addition, musculoskeletal complaints were common among NSTs and significantly linked to a poor ventilation system, an increased number of customers per day, and a longer service duration. Furthermore, a longer career duration was significantly associated with an increased prevalence of irritative symptoms. When a binary logistic regression was carried out, it demonstrated a 25 times higher prevalence of work-related symptoms among NSTs compared to the office employees. Interestingly, 84% of the respondents had an inaccurate knowledge of nail cosmetics’ risks with their educational level acting as key factor.

Conclusions:

Based on these findings, it is warranted to perform a clinical assessment, implement a stringent regulatory framework, and improve knowledge toward nail cosmetics’ risk.
Neuro-Oncology Training for the Child Neurology Resident
Authors: Malbari Fatema , Partap Sonia , Gust Juliane , Duke Elizabeth , Sato Aimee , Khakoo Yasmin , Ullrich Nicole J.
Published: September 2020

Neuro-oncology is a rapidly evolving subspecialty that involves the management of patients with primary or metastatic central and peripheral nervous system neoplasms, as well as any other disorders or complications affecting the nervous system that result either directly or indirectly from central nervous system or systemic malignancies and related treatment. Neurologists serve a critical role in the multidisciplinary management of these complex patients. As leaders of the Child Neurology Society Special Interest Group in NeuroOncology, we propose ways to provide sufficient exposure, minimize knowledge gaps, and optimize training experiences in neuro-oncology for child neurology residency programs.
Speed-adaptive motion control algorithm for differential steering vehicle
Authors: Du Peng , Ma Zhongmin , Chen Hao , Xu Da , Wang Yuan , Jiang Yanhua , Lian Xiaomin
Published: September 2020

The differential steering vehicle uses the in-wheel motors to drive the wheels directly and individually. However, in order to deliver the required structural robustness, the differential steering vehicle discarded the mechanical steering system and achieved vehicle steering by applying differential speed between the left and right wheels. This paper presents a novel speed-adaptive motion control algorithm based on the unique chassis configuration to enhance the performance in vehicle handling and lateral stability. The proposed control method first estimates the driver’s driving intention, from which reference wheel speeds are individually generated for each wheel based on their respective slipping and skidding status. Finally, the torque command is automatically adjusted by the speed-tracking controller by proactive adaptation of the wheel spinning resistance to effectively avoid excessive slip on low friction. This method exploits the fact that the torque at the steady state will always be equal to the available longitudinal force, thereby delivering the sophisticated tire force estimation without additional computational efforts, and ultimately helping conserve energy and promote lateral stability. The essential road information collected by this algorithm is also made available to drivers for improved vehicle controllability. The algorithm is subjected to three experimental case scenarios—pivot steering, low-friction driving, and curvilinear driving—through TruckSim–Simulink co-simulations and real vehicle tests, and the results have validated the algorithm in realizing the high-performance steering and maneuvering capabilities for six-wheeled differential steering vehicles.
Young EU migrant citizens’ access to financial independence in conditions of precarious work: A tripartite approach to welfare conditionality
Authors: Simola Anna , Wrede Sirpa
Published: September 2020

Young EU citizens are encouraged to enhance their ‘employability’ by taking advantage of intra-EU mobility, but, for many, moving to another EU country can instead generate disadvantages in the labour market. Drawing on a qualitative study on the experiences of university-educated young Nordics and southern Europeans working in precarious jobs in Brussels, we examine how their access to income support in the context of mobility shapes their access to financial independence. We argue that the variation in European welfare models regarding young peoples’ social entitlements impacts this access in multiple and complex ways. The article advances a tripartite approach that looks at the regulation and enforcement of conditionality of social entitlements on the levels of EU, their country of origin and their country of destination. The analysis shows how, in Belgium, precarious EU migrant citizens are denied access to income support due to the interplay between general welfare conditionality for all claimants and recently reinforced conditionality affecting EU migrant citizens in particular. In these situations, the de-familialising Nordic welfare models showed an aptitude for shielding their young citizens. The young southern Europeans, on the other hand, often had no access to income support in any country, which forced them to choose between family dependency and unfiltered exposure to precarity.
A rapid neural network–based state of health estimation scheme for screening of end of life electric vehicle batteries
Authors: Rastegarpanah Alireza , Hathaway Jamie , Ahmeid Mohamed , Lambert Simon , Walton Allan , Stolkin Rustam
Published: September 2020

There is growing interest in recycling and re-use of electric vehicle batteries owing to their growing market share and use of high-value materials such as cobalt and nickel. To inform the subsequent applications at battery end of life, it is necessary to quantify their state of health. This study proposes an estimation scheme for the state of health of high-power lithium-ion batteries based on extraction of parameters from impedance data of 13 Nissan Leaf 2011 battery modules modelled by a modified Randles equivalent circuit model. Using the extracted parameters as predictors for the state of health, a baseline single hidden layer neural network was evaluated by root mean square and peak state of health prediction errors and refined using a Gaussian process optimisation procedure. The optimised neural network predicted state of health with a root mean square error of (1.729 ± 0.147)%, which is shown to be competitive with some of the most performant existing neural network–based state of health estimation schemes, and is expected to outperform the baseline model with ∼50 training samples. The use of equivalent circuit model parameters enables more in-depth analysis of the battery degradation state than many similar neural network–based schemes while maintaining similar accuracy despite a reduced dataset, while there is demonstrated potential for measurement times to be reduced to as little as 30 s with frequency targeting of the impedance measurements.
Senescence marker protein 30 confers neuroprotection in oxygen-glucose deprivation/reoxygenation-injured neurons through modulation of Keap1/Nrf2 signaling: Role of SMP30 in OGD/R-induced neuronal injury
Authors: Liu Wenxiong , Zhao Haikang , Su Yuqiang , Wang Kefeng , Li Jing , Xue Sha , Sun Xiaopeng , Qiu Zhengguo
Published: September 2020

Senescence marker protein 30 (SMP30) is a senescence marker molecule and identified as a calcium regulatory protein. Currently, SMP30 has emerged as a cytoprotective protein in a wide range of cell types. However, the role of SMP30 in regulating neuronal survival during cerebral ischemia/reperfusion injury remains unclear. In the present study, we aimed to investigate the biological function and regulatory mechanism of SMP30 on neuronal survival using a cellular model induced by oxygen-glucose deprivation/reoxygenation (OGD/R). The results showed that SMP30 expression was significantly decreased by OGD/R exposure in neurons. Functional experiments demonstrated that SMP30 overexpression significantly rescued the decreased cell viability and attenuated the apoptosis and reactive oxygen species generation in OGD/R-exposed neurons. By contrast, SMP30 knockdown exhibited the opposite effect. Mechanism research revealed that SMP30 overexpression contributed to the activation of nuclear factor erythroid 2-related factor (Nrf2)/antioxidant response element (ARE) signaling associated with downregulation of Kelch-like ECH-associated protein (Keap1). Keap1 overexpression or Nrf2 silencing significantly reversed SMP30-mediated neuroprotection against OGD/R-induced injury. Overall, these findings demonstrate that SMP30 overexpression protects neurons from OGD/R-induced apoptosis and oxidative stress by enhancing Nrf2/ARE antioxidant signaling via inhibition of Keap1. These data highlight the importance of the SMP30/Keap1/Nrf2/ARE signaling axis in regulating neuronal survival during cerebral ischemia/reperfusion injury.
Possible mechanism of bamboo shoots (Bambusa balcooa) induced thyroid disruption – An in vitro study
Authors: Sarkar D , Chandra AK , Chattopadyay S , Biswas M , Das S , Singh LH , Ray I
Published: September 2020

Endemic goitre and associated iodine deficiency disorders (IDDs) are a major concern in public health even in the period of post salt iodization in many regions. Among others the consumption of cyanogenic plants found responsible for the persistence of such diseases. Bamboo shoots (BS) is one such cyanogenic plant food that caused disruption of certain thyroid hormone synthesizing regulatory element as has already been reported in our earlier study. In this investigation the possible mechanism of thyrocytes disruption along with interruption of thyroid hormone biosynthesis by BS has been worked out. Commonly consumed BS, Bambusa Balcooa Roxb (BBR) water extract was analysed by GC MS; three doses below IC50 were administered to thyrocytes in culture with and without iodine. Expressions of thyroglobulin (Tg), pendrin (PDS) and monocarboxylate transporter 8 (MCT8) were evaluated in thyrocytes with cell cycle analysis, reactive oxygen species (ROS) generation, DNA oxidation and apoptotic regulation through Bax, Bcl-2 and p53. Phytochemical analysis of BBR extract revealed the presence of precursors and metabolic end products of cyanogenic glycosides. Dose dependent decrease in expression of Tg and PDS with concomitant decrease in gene expression of these with MCT8 were observed. Increased ROS, DNA oxidation and associated imbalance were found through increased Bax and p53 with decreased Bcl-2 that perturbed thyrocytes cell cycle. Cyanogenic constituents of BBR generates ROS associated oxidative changes in thyrocytes with DNA damage and oxidation and cell cycle disruption followed by inhibition of thyroid hormone synthesizing regulatory elements; addition of extra iodine showed partial prevention.
What Influences the Choice of Ibrutinib–Rituximab vs Classic Chemoimmunotherapy for Chronic Lymphocytic Leukemia?
Authors: Bravaccini Sara , Martinelli Giovanni , Cerchione Claudio
Published: September 2020

Chronic lymphocytic leukemia (CLL), with an incidence rate between 4 and 6 cases per 100,000 persons per year, is considered the most prevalent leukemia in the western world. Chemoimmunotherapy (such as fludarabine, cyclophosphamide, and rituximab), bendamustine plus rituximab, and, more recently, novel agents such as ibrutinib (Bruton tyrosine kinase inhibitor), idelalisib (phosphatidylinositol-3-kinase δ inhibitor), and venetoclax (BCL-2 inhibitor) have changed the management of CLL. Shanafelt and colleagues compared the efficacy of ibrutinib–rituximab with that of standard chemoimmunotherapy in patients with treatment-naïve CLL. They did not, however, mention that the therapy varies on the basis of where patients live and, given that local guidelines not immediately reflect US Food and Drug Administration (FDA) updates, discrepancies in treatment occur. Important CLL goals are the availability of rapidly reproducible tests, standardization of national and international guidelines, and FDA approval-based treatment reimbursement.
8-Chloro-Adenosine Inhibits Proliferation of MDA-MB-231 and SK-BR-3 Breast Cancer Cells by Regulating ADAR1/p53 Signaling Pathway
Authors: Ding Hong-Yue , Yang Wan-Yong , Zhang Li-Hong , Li Li , Xie Feng , Li Hua-Yi , Chen Xiao-Yu , Tu Zeng , Li Yi , Chen Yong , Yang Sheng-Yong
Published: September 2020

8-Chloro-adenosine (8-Cl-Ado) has been shown to exhibit its antitumor activity by inducing apoptosis in human lung cancer A549 and H1299 cells or autophagy in chronic lymphocytic leukemia, and MDA-MB-231 and MCF-7 breast cancer cells. Adenosine deaminases acting on RNA 1 (ADAR1) is tightly associated with cancer development and progression. The aim of this study was to investigate the role of ADAR1 in the proliferation of MDA-MB-231 and SK-BR-3 breast cancer cell lines after 8-Cl-Ado exposure and its possible mechanisms. After 8-Cl-Ado exposure, CCK-8 assay was performed to determine the cell proliferation; flow cytometry was used to analyze the cell cycle profiles and apoptosis; and the protein levels of ADAR1, p53, p21, and cyclin D1 were measured by western blotting. The results showed that the cell proliferation was greatly inhibited, G1 cell cycle was arrested, and apoptosis was induced after 8-Cl-Ado exposure. ADAR1 and cyclin D1 protein levels were dramatically decreased, while p53 and p21 levels were increased after 8-Cl-Ado exposure. Moreover, the cell growth inhibition was rescued, apoptosis was reduced, and p53 and p21 protein levels were downregulated, while cyclin D1 was upregulated when cells were transfected with plasmids expressing ADAR1 proteins. More importantly, RNA-binding domain of ADAR1 is critical to the cell growth inhibition of breast cancer cells exposed to 8-Cl-Ado. Together, 8-Cl-Ado inhibits the cell proliferation, induces G1 phase arrest and apoptosis at least by targeting ADAR1/p53/p21 signaling pathway. The findings may provide us with insights into the role of ADAR1 in breast cancer progression and help us better understand the effects of 8-Cl-Ado in the treatment of breast cancer.
Selection of Retirement Saving Plan for a Private-sector Employee in Pakistan
Authors: Naqvi Bushra , Rizvi Syed Kumail Abbas , Shahzad Arsalan
Published: September 2020

Tehmina Khan, a 35-year-old, married mother of two, had been working as an assistant professor at a private sector university, University of Management and Information (UMI), School of Business. For the last few years, she had been saving for her retirement via a provident fund (PF) with her employer. The fund had been posting generous returns for years up until July 2018, when it posted earnings well below the inflation rate for the same period. Tehmina wanted to be financially self-sufficient in her post-retirement years and sought no financial dependence on her posterity for that matter. The meagre returns heightened her concerns about the future eventualities, so she had to decide if she should switch to another retirement plan. She needed to explore alternative retirement plans and identify how she could participate in a voluntary pension system (VPS) outside her employer’s PF. Also, if she decided to go ahead with VPS, she had to decide which asset management company(s) and portfolio manager(s) to allocate her savings to.

The case comprehensively discusses the details about different retirement benefits and mechanisms and distinguishes aspects of private and public sector retirement plans in Pakistan. Most importantly, the case includes data on the performance of seventeen out of a total of nineteen pension plans operating in Pakistan. It also includes data on asset allocations of pension funds; overall macroeconomic, historical and stock market performances; and yield curve for the last 10 years.
Electroconvulsive therapy, personal protective equipment and aerosol generating procedures: a review to guide practice during Coronavirus Disease 2019 (COVID-19) pandemic
Authors: Purushothaman Subramanian , Fung David , Reinders Jonathan , Garrett-Walcott Simone , Buda Margaret , Moudgil Vikas , Emmerson Brett
Published: September 2020

Objective:

To review the literature on the definition of aerosol-generating procedures (AGPs), identify high-risk AGPs, guidelines to use personal protective equipment (PPE) and review evidence to see if electroconvulsive therapy (ECT) is a high-risk AGP requiring the use of PPE.

Methods:

Existing guidelines and research data were reviewed to answer the questions.

Results:

There is consensus about the type of anaesthesia used during ECT, what constitutes AGPs and what PPE should be used. It was not clear if ECT was an AGP, but we argue that it is one based on evidence.

Conclusion:

We conclude that ECT is an AGP and that it requires the appropriate use of PPE after taking in to account local supply and demand.
Oromandibular Limb Hypogenesis Syndrome: Overlap of Moebius and Ankyloglossia Superior With Severe Limb Defects
Authors: Carvalho Lúcia Rosa Reis de Araújo , Pinto Lucielma Salmito Soares , de Sousa Geovanna Peres , Correia José Pascoal Duarte Pinheiro , de Moura Marcoeli Silva
Published: September 2020

The oromandibular limb hypogenesis syndromes (OLHS) represent a group of rare conditions characterized by congenital malformations involving the tongue, mandible, and limbs. In this report, we describe a newborn girl with paralysis of abducens and facial nerves, transverse agenesis of the distal segments of the limbs, micrognathia, cleft lip and palate, and ankyloglossia superior. This observation confirms an overlap between Moebius syndrome and ankyloglossia superior syndrome with severe limb defects. The etiology of the OLHS is not clearly understood. The intriguing link between facial and limb anomalies can result from their simultaneous development from the fourth to eighth week of gestation, making both areas susceptible to the same teratogenic stimuli. There is an overlap between OLHS conditions, supporting a clustering, rather than a divided nosology and requiring an appropriate classification of these conditions. Patients with OLHS can be successfully managed using a multidisciplinary approach.
Framing the Origins of COVID-19
Authors: Bolsen Toby , Palm Risa , Kingsland Justin T.
Published: September 2020

Conspiracy theories have flourished about the origins of a novel coronavirus (SARS-CoV-2) that causes an acute respiratory syndrome (coronavirus disease 2019 [COVID-19]) in humans. This article reports the results from a study that evaluates the impact of exposure to framed messages about the origins of COVID-19. We tested four hypotheses: two focusing on its origins as either zoonotic or human-engineered and two concerning the impacts of origin beliefs on the desire to penalize China or support increased funding for biomedical research. The results accentuate the importance of finding ways to combat the spread of misinformation and conspiracy theories related to this global pandemic.
A Bioecological Theory of Sexual Harassment of Girls: Research Synthesis and Proposed Model
Authors: Brown Christia Spears , Biefeld Sharla D. , Elpers Nan
Published: September 2020

In the United States, many adolescent girls experience sexual harassment before they leave high school, and between 20% and 25% of college women are survivors of sexual assault. Despite the many negative consequences associated with these experiences, perpetrating sexual harassment and assault is often viewed as normative. Using Bronfenbrenner’s bioecological theoretical framework, we propose a bioecological theory of the perpetration and tolerance of sexual harassment of girls. We propose children’s proximal and distal contexts contribute to the endorsement of sexualized gender stereotypes, which in turn impacts high rates of both perpetration and acceptance of sexual harassment. We discuss the ways that three important microsystems—parents, peers, and schools—contribute to this acceptance. We also propose that key components of media within the exosystem work to further normalize sexual harassment of girls and women. These contexts inform children’s development, creating a culture that is permissive of sexual harassment, resulting in high rates of sexual harassment and assault in adolescence and emerging adulthood. Implications of our proposed theory for policymakers, teachers, parents, and researchers are discussed.
Teaching hip surgery to orthopaedic residents: what’s new?
Authors: De Boey Sara , Maes Michael , Mertens Peter
Published: September 2020

Purpose:

The purpose of this study is to provide an overview of the published literature on the existing educational methods used to teach surgical skills, with a specific focus on hip surgery, to orthopaedic residents.

Methods:

A total of 31 articles were selected from a PubMed literature search on the topic of teaching surgical skills to orthopaedic residents, and 9 articles on hip surgery are included in this review.

Results:

Although several methods are included in the published literature to teach orthopaedic residents, only arthroscopy of the knee and shoulder joint is well described. Hip arthroscopy has a steeper learning curve and thus the use of simulation training as a complementary teaching method is even more important.

Conclusions:

Currently, open surgery skills for joint arthroplasty are largely acquired by apprenticeship learning. Simulation training in the form of virtual reality could contribute to better performance of residents, decreasing operation time and improving patient safety.
Debridement, antibiotic pearls, and retention of the implant in the treatment of infected total hip arthroplasty
Authors: Ghirardelli Stefano , Fidanza Andrea , Prati Paolo , Iannotti Ferdinando , Indelli Pier F
Published: September 2020

In this article the authors describe a modified surgical technique developed to enhance the classical irrigation and debridement procedure to improve the possibilities of retaining a total hip arthroplasty (THA) undergoing acute periprosthetic joint infection (PJI). This technique, debridement antibiotic pearls and retention of the implant (DAPRI), aims to remove the intra-articular biofilm allowing a higher and prolonged local antibiotic concentration by using calcium sulphate antibiotic-added beads. The combination of 3 different surgical techniques (tumour-like synovectomy, Argon Beam application and chlorhexidine gluconate brushing) might enhance the disruption and removal of the bacterial biofilm which is the main responsible of antibiotics and antibodies resistance. The timing of the diagnosis (6 weeks from the original surgery or 1 week from clinical symptoms appearance in the case of an hematogenous infection) and the preoperative isolation of the germ are fundamental in order to obtain a satisfactory outcome. A 12-week course of postoperative antibiotic therapy (6 weeks I.V. and 6 weeks oral) complete the postoperative protocol used by the authors.

The DAPRI technique might represent a safe and more conservative treatment for acute and early hematogenous PJI.