bluuebunny/crossref_metadata_2025 huggingface dataset:
A Randomized Trial of Lipid Metabolism Modulation with Fenofibrate for Acute Coronavirus Disease 2019
Authors: Chirinos Julio , Lopez-Jaramillo Patricio , Giamarellos-Bourboulis Evangelos , Dávila-del-Carpio Gonzalo , Bizri Abdul , Andrade-Villanueva Jaime , Salman Oday , Cure-Cure Carlos , Rosado-Santander Nelson , Giraldo Mario Cornejo , González-Hernández Luz , Moghnieh Rima , Angeliki Rapti , Saldarriaga María Cruz , Pariona Marcos , Medina Carola , Dimitroulis Ioannis , Vlachopoulos Charalambos , Gutierrez Corina , Rodriguez-Mori Juan , Gomez-Laiton Edgar , Pereyra Rosa , Hernández Jorge Ravelo , Arbañil Hugo , Accini-Mendoza José , Pérez-Mayorga Maritza , Milionis Haralampos , Poulakou Garyfallia , Sánchez Gregorio , Valdivia-Vega Renzo , Villavicencio-Carranza Mirko , Ayala-Garcia Ricardo , Castro-Callirgos Carlos , Carrasco Rosa Alfaro , Danos Willy Lecca , Sharkoski Tiffany , Greene Katherine , Pourmussa Bianca , Greczylo Candy , Chittams Jesse , Katsaounou Paraskevi , Alexiou Zoi , Sympardi Styliani , Sweitzer Nancy , Putt Mary , Cohen Jordana
Published: August 2022

Background
Abnormal cellular lipid metabolism appears to underlie SARS-CoV-2 cytotoxicity and may involve inhibition of peroxisome proliferator activated receptor alpha (PPARα). Fenofibrate, a PPAR-α activator, modulates cellular lipid metabolism. Fenofibric acid has also been shown to affect the dimerization of angiotensin-converting enzyme 2, the cellular receptor for SARS-CoV-2. Fenofibrate and fenofibric acid have been shown to inhibit SARS-CoV-2 replication in cell culture systems in vitro.
Methods
We randomly assigned 701 participants with COVID-19 within 14 days of symptom onset to 145 mg of fenofibrate (nanocrystal formulation with dose adjustment for renal function or dose-equivalent preparations of micronized fenofibrate or fenofibric acid) vs. placebo for 10 days, in a double-blinded fashion. The primary endpoint was a ranked severity score in which participants were ranked across hierarchical tiers incorporating time to death, duration of mechanical ventilation, oxygenation parameters, subsequent hospitalizations and symptom severity and duration. ClinicalTrials.gov registration: NCT04517396.
Findings:
Mean age of participants was 49 ± 16 years, 330 (47%) were female, mean BMI was 28 ± 6 kg/m2, and 102 (15%) had diabetes mellitus. A total of 41 deaths occurred. Compared with placebo, fenofibrate administration had no effect on the primary endpoint. The median (interquartile range [IQR]) rank in the placebo arm was 347 (172, 453) vs. 345 (175, 453) in the fenofibrate arm (P = 0.819). There was no difference in various secondary and exploratory endpoints, including all-cause death, across randomization arms. These results were highly consistent across pre-specified sensitivity and subgroup analyses.
Conclusion
Among patients with COVID-19, fenofibrate has no significant effect on various clinically relevant outcomes.
Key habitats and breeding zones of threatened golden eagles in Eastern North America identified by multi-level habitat selection study
Authors: Maynard Laurie D. , Lemaître Jérôme , Therrien Jean-François , Miller Tricia A. , Katzner Todd , Somershoe Scott , Cooper Jeff , Sargent Robert , Lecomte Nicolas
Published: August 2022

Context: Wildlife surveys are limited by the capacity to collect data over the spatial extent of a population, which is challenging and costly for species of large geographic distribution in remote regions. Multi-level habitat selection models can limit the surveying extent and become tools for conservation management by identifying key areas and habitats. Objectives: We studied habitat selection of the threatened Eastern North American population of golden eagles (Aquila chrysaetos) with a multi-level approach over the population’s distribution to identify key habitats and zones of interest. Methods: Using tracking data of 30 adults and 276 nest coordinates, we modelled habitat selection at three levels: landscape, foraging and nesting. Results: At the landscape level, eagles selected topographical features (i.e., terrain ruggedness, elevation) more strongly than land cover features (forest cover, distance to water; mean difference: 0.98, CI: 0.37), suggesting that topographical features, facilitating flight and movement through the landscape, are more important than land cover, indicative of hunting opportunities. We also found that home range size was 50% smaller and relative probability of selection at all three levels was ~ 25% higher in the polar regions than boreal regions. It suggests that eagles in polar regions travel shorter foraging distances and habitat characteristic is more suitable. Conclusion: Using multi-level models, we identified key habitat characteristics for a threatened population over a large spatial scale. We also identifying areas of interest to target for a variety of life cycle needs.
Immune- Checkpoint Inhibitors in Malignant Pleural Mesothelioma: a meta-analysis
Authors: Gemelli Maria , Cortinovis Diego Luigi , Baggi Alice , Mauro Pierluigi di , Calza Stefano , Grisanti Salvatore , Rota Matteo
Published: August 2022

Introduction
Malignant pleural mesothelioma (MPM) is an aggressive disease with poor prognosis. Many trials investigated the role of Immune Checkpoint Inhibitors (ICIs) in MPM, with contrasting results.
Methods
We performed a meta-analysis of clinical trials testing single-agent anti PD-1/PD-L1, anti-CTLA-4 or their combination in MPM patients. Objective response rate (ORR), disease control rate (DCR), 6 months progression-free survival (PFS) and 12 months overall survival (OS) rate were extracted, as well as safety data. The predictive role of PD-L1 was assessed, too.
Results
We selected 17 studies including 2328 patients. 12 months OS was 53% (95% CI 44–61%), 6 months PFS was 19% (95% CI 13–25%). Both OS and PFS were significantly higher with combined ICIs treatment than single agent anti PD-1/PD-L1 (respectively p < 0.001 and p = 0.006) or anti CTLA-4 (p < 0.001). ORR and DCR were 20% (95% CI 13–27%) and 56% (95% CI 45–67%) and did not significantly differ between combined and single agent ICIs (p = 0.088 and p = 0.058). 12 months OS and 6 months PFS rate did not differ significantly (p = 0.0545 and p = 0.1464) among pre-treated or untreated patients. Combined ICIs treatments have significantly higher rate of Adverse Events (AEs) (p = 0.01). PD-L1 positive patients have higher ORR, DCR and OS than PD-L1 negative patients.
Conclusion
ICIs are an efficient treatment option for MPM. Efficacy was independent from treatment line, so customized sequential strategy should still be speculated. PD-L1 expression could influence response to ICIs, however reliable biomarkers are warranted.
Medical Student Mentorship in the COVID-19 Era
Authors: Bishop Ryan , Sethia Rishabh , Allen David , Roy Soham , Elmaraghy Charles
Published: August 2022

ObjectiveTo determine the perspective of then third- and fourth-year medical students regarding the impact of the COVID-19 pandemic on mentorship.MethodsThe authors distributed a modified Likert scale questionnaire (score: 1-10) to third- and fourth-year medical students at two large US allopathic medical schools from the class of 2021 and 2022. Responses to each survey item were analyzed to characterize the impact of the COVID-19 pandemic on mentorship relationships in medical school. A score of 1-5 was considered “disagree” and a score of 6-10 was considered “agree”. ResultsA total of 144 responses were collected with a response rate of 16.2%. Overall, 80.6% (n=116) of respondents agree that the COVID-19 pandemic had a negative impact on their medical school experience. Nearly half (41.0%, n=59) expressed concern over the lack of mentorship opportunities, and 66.0% (n=95) reported that the pandemic made it more difficult to form or maintain connections with their mentors. Importantly, 43.6% (n=61) of respondents reported that having close mentoring relationships reduced the impact of the pandemic on their medical training. While many respondents (79.9%, n=114) did not change career plans due to the pandemic, most students were concerned about evaluating prospective residency programs (88.9%, n=128). Notably, M3s had much lower confidence than M4s in their ability to choose a specialty (5.9 vs. 8.2, p = 6.43e-08).ConclusionsThis investigation illustrated the concerns that medical students had regarding access to mentorship opportunities during the COVID-19 pandemic. We hope that these findings encourage medical schools to evaluate and expand their current mentorship programs.
Efficacy of cryotherapy combined with intralesional tuberculin purified protein derivative (PPD) versus intralesional tuberculin PPD monotherapy in the treatment of multiple common warts
Authors: Awad Sara M , Gomaa Ahmed S , Hassan Hiba A , Tawfik Yasmin M
Published: August 2022

Introduction:Intralesional antigen immunotherapy represents a promising therapeutic approach for the treatment of different types of warts, particularly if multiple and/or recalcitrant.Aim:This work aimed to investigate the efficacy and safety of combined cryotherapy with intralesional purified protein derivative (PPD) immunotherapy in the treatment of multiple common warts.Methods:Fifty patients were randomly divided into two groups (25 patients each): Group A: receiving intralesional PPD immunotherapy, while group B: receiving cryotherapy plus intralesional PPD. Treatments were performed every 2 weeks for a maximum of four sessions. Photographs were taken at baseline and at each visit and clinical response was evaluated by the reduction in number and size of warts. Adverse effects were recorded.Results:There was a significant reduction in size and number of warts in both groups (P<0.001), with no significant difference between the two groups. Complete clearance of the lesions was observed in 48% of patients in group A and 44% in group B (P=0.39). Higher rates of near complete/complete response were achieved after fewer sessions (2-3 sessions) in group B (P=0.002). Blistering was common after cryotherapy. Higher rate of hypopigmentation was noticed after combined treatment than after PPD monotherapy (56% vs. 8% respectively; P<0.001), which resolved gradually.Conclusion:Both intralesional PPD alone and combined cryotherapy with PPD are safe and effective in clearing of common warts. Cryotherapy may be a successful adjunct to intralesional PPD immunotherapy that helps in reducing the number of treatment sessions.
Effectiveness of Ultrasound-guided Dual Nerve Block in the Below-knee Amputation
Authors: Lee Dong Ha
Published: August 2022

Introduction: Below knee amputation (BKA) is a common surgical procedure for diabetic foot ulcers and necrotizing lower limb fasciitis patients. But, it is a painful procedure and inadequate postoperative analgesia impedes rehabilitation and prolongs hospitalization. An ideal pain management regimen should provide superior analgesia while minimizing opioid consumption and improving rehabilitation.Methods: We retrospectively reviewed medical charts of 218 patients who underwent BKA for diabetic foot ulcer or necrotizing lower limb fasciitis at a single center between January 2017 and September 2020. Two groups were analyzed: patients who received dual nerve block (DNB) before surgery (Group I; n=104), and patients who did not (Group II; n=93). By the exclusion criteria, 21 patients were excluded. The femoral, and sciatic nerves were each blocked separately under ultrasound guidance. This procedure was performed immediately before the operation. Results: Group I patients' subjective pain scores were significantly lower than those of Group II at 6, 12, and 24 hours after BKA (P <0.05). Group I’s morphine milligram equivalent (MME) was significantly lower than those of Group II at 72 hours after BKA (P <0.05). Also, the rate of postoperative nausea and vomiting (PONV) and delirium was significantly lower in Group I patients than those in Group II patients.Conclusion: Ultrasound-guided lower extremity nerve block surgery is excellent for early post-operative pain control, could be used as an accurate, and effective pain control method, and can reduce side effects of opioid consumption after BKA.
SDFC Dataset: A Large-Scale Benchmark Dataset for Hyperspectral Image Classification
Authors: Sun Liwei , Zhang Junjie , Li Jia , Wang Yueming , Zeng Dan
Published: August 2022

Hyperspectral image (HSI) classification plays an important role in a wide range of remote sensing applications in military and civilian fields. During past decades, significant efforts have been made on developing datasets and introducing novel approaches to promote HSI classification, such that promising classification performance has been achieved. However, existing datasets generally pose following issues, including the limited categories and annotated samples, the lack of sample diversity, as well as the low spatial resolution. These limitations severely restrict the development and evaluation of data-driven models, especially deep neural network-based ones. In recent years, advances in imaging spectroscopy provide us the opportunity to obtain the hyperspectral image data with high spectral and spatial resolution, therefore, in this paper, we contribute a large-scale benchmark dataset for conducting hyperspectral image classification to address issues raised by existing datasets, noted as ShanDongFeiCheng (SDFC). The proposed SDFC is characterized by 1) the large-scale annotated samples with diverse categories; 2) the high spatial resolution; and 3) the high intra-class variance yet relatively low inter-class variance, making the HSI classification task much more challenging on it. We evaluated 10 classic traditional and deep neural network-based models on SDFC, of which the results can be regarded as useful baselines for further experiments. Moreover, given the state-of-the-art performance of SpectralNet, we selected it as the representation method, and evaluated it across datasets to analyze the difference effects on the classification model induced by different datasets. The comprehensive review and analysis of representative classification models on both existing and proposed datasets demonstrate the advantages and challenges of our proposed dataset, and provide promising perspectives for future HSI classification studies.
In vivo and in vitro validation of powdery mildew resistance in garden pea genotypes
Authors: Rana Chanchal , Sharma Akhilesh , Rathour Rajeev , . Bansuli , Banyal Devinder Kumar , Sharma Parveen
Published: August 2022

Powdery mildew is one of the serious diseases of garden pea which causes a large number of yield losses. Genetic resistance is quite effective, being cost-effective and environment friendly than fungicide applications. In the present studies an initial attempt has been made to identify resistant genotypes against powdery mildew disease developed from hybridization followed by validation of the disease. The newly isolated 44 lines along with four checks were screened under natural and artificial conditions. Ten lines viz., SP7, SN-1, SN-6-1, SN-7-1, SN-2, SN-5-2, SN-6-2, SN-21 and SP-28-1 showed resistant reaction along with check Palam Sumool while 27 lines were identified as moderately resistant in comparison to susceptible check Azad P-1. Besides, six lines namely, SP-2, SP-5, SP-10, SP-24, SA-4 and SP-12-1 gave moderately susceptible reaction along with checks Pb-89 and Palam Priya. Only, SP-19 was categorized as susceptible. The high yielding lines SP-3, SP-6 and SP-22 showed moderately resistant reaction in both natural and artificial conditions. Validation of resistance using molecular markers revealed that neither the parental genotypes nor the progenies possess the er1 gene of JI1559. The er2 linked marker ScOPX-171700 was polymorphic between Palam Sumool and Palam Priya but the marker didn’t show polymorphism between er2 harboring line (JI2480). These results suggested that the lines showing resistance under field conditions may have some other genes or alleles for resistance and further confirmation is needed by developing mapping populations with specific gene or gene combinations.
Availability and Advice on Test uptake: a vignette study on Covid-19 self-testing policy.
Authors: Zomer Colene , Kroese Floor , Sanders Jet , Janssen Riny , de Bruin Marijn
Published: August 2022

To inform future Dutch Covid-19 testing policies we did an experimental vignette study to investigate whether inclusion of the less reliable lateral flow tests (self-tests) would change test-uptake sufficiently to improve population-level test sensitivity. A representative sample (n = 3.270) participated in a 2-by-2 online experiment to evaluate the effects of test-guidelines including self-testing advice (IV1), and the effects of self-test availability (IV2) on test uptake (PCR test, self-test or no test) and sensitivity of the overall test strategy (primary outcome). Across four scenarios, changing test advice did not affect testing behaviour. Self-test availability, however, increased the timeliness of testing, the number of people testing, and overall test strategy sensitivity. Based on these findings, we recommend that (national) policy facilitates a supply of self-tests at home, for example through free and pro-active distribution of test-kits. This could substantially enhance the chances of timely detecting and isolating COVID-19 patients.
Mupirocin Blocks Imiquimod-induced Psoriasis-like skin Lesion by Inhibiting Epidermal Isoleucyl-tRNA Synthetase
Authors: Man Xiao-Yong , Yan Bing-Xi , Chen Xue-Yan , Wang Zhao-Yuan , Cui Ying-Zhe , Landeck Lilla , Fu Ni-Chang , Yang Xing-Yu , Xu Fan , Zhou Yuan , Chen Jia-Qi
Published: August 2022

Background: The Isoleucyl-tRNA synthetase (IARS) catalyzes isoleucine to the corresponding tRNA, maintaining the accuracy of gene translation. Its role in psoriasis has been not investigated so far. In this study, we aimed to investigate the mechanisms underlying the efficacy of IARS inhibitor, mupirocin, treatment for psoriasis.Methods: The expression of IARS was determined by immunofluorescence, Western blot and qRT-PCR in normalhealthy control- and psoriatic human skin. An imiquimod（IMQ）-induced psoriasis-like skin disease model was used to study the phenotypes changed by an IARS inhibitor, mupirocin (MUP). Endotypes were analyzed by RNA-seq, R&D Luminex multi-factor technique, ELISA, immunofluorescence and flow cytometry. Additionally, the effect of MUP on epidermal keratinocytes (KCs) were conducted in-vitro in primary cultured human KCs.Results: We found the expression of IARS was higher in psoriatic skin than in healthy controls. In IMQ-induced psoriasis-like C57BL/6 mouse model, MUP reversed IMQ-induced keratinocytes proliferation, expression of inflammatory cytokines and infiltration of immune cells. Furthermore, in cultured human keratinocytes, MUP inhibited proliferation, but promoted apoptosis, which may be related with STAT3 signaling pathway. Conclusion: Our finding of blocking the infiltration of immune cells by inhibiting the formation of IARS, could be one mechanism to explain the effect of MUP in the treatment of psoriasis. Developing strategies targeting suppression IARS should open new perspectives for the treatment of psoriasis.
Evaluation of Efficacy & Safety of Isotine Plus I Drops in Patients suffering from Immature Uncomplicated Cataract - An Open Labeled, Comparative, Multi-centric, Two Arm, Prospective, Interventional Clinical Study
Authors: Tamoli Sanjay , Agiwal Sachin , Bagde Sachin , Ingle Pushpalata , Pande Shishir , Bhandary Sapna , Ghedge Gayatri , Kalkaru Rashmi
Published: August 2022

Background
Cataract is one of the commonest ocular disorders in elderly population and major cause of blindness. Natural compounds consisting of antioxidant and anti-inflammatory phytoconstituents can serve as probable leads for anticataract agents.The ingredients present in the Isotine Pus I drops may help in improving vision and delay progression of cataract.
Hypothesis/Purpose:
The present clinical study was conducted to evaluate efficacy and safety of Isotine Plus I Drops in patients suffering from immature uncomplicated cataract.
Methods
This open label, comparative, multicentric, two arm, prospective, interventional clinical study was carried out at three study centres.A total of 69 subjects were enrolled in the study of which there were 61 completers – 30 in Isotine group and 31 in control group.Subjects in Isotine group were instructed to use 2 drops in each eye twice daily for a period of 6 months (180 days), while subjects in control group were instructed to continue the conventional treatment, which they were already taking as prescribed by ophthalmologist. The study involved the use of slit lamp microscopic examination in tangential sectioning of lens and retro-illumination technique for grading of cataract and other scales for overall change and safety.
Results
With a treatment of six months, a statistically significant higher number of subjects showed improvement in Isotine Plus I drop group as compared to the conventional treatment group as observed with slit lamp and opthalmic examinations. Various scales used in the study to evaluate the extent of cataract and vision showed that with the use of Isotine Plus I drops there was a significant difference in cataract condition. Isotine Plus I Drops was found to be safe on regular long-term use without producing any adverse effects.
Conclusion
Regular use of Isotine Plus I Drops in a dose of 2 drops twice daily for a period of 6 months helps in arresting the progression and thus management of cataract.
Stability Analysis of Rock-Socketed Piles on Inclined Slope: Case Study on Conveyor Belt Foundations of Dangote Cement, Ethiopia
Authors: Dadi Oliyad Megersa , Chala Endalu Tadele
Published: August 2022

This study was carried out the stability analysis of rock-socketed pile on inclined slope at Dangote Cement (Ethiopia) around C1-12A, C1-13A and C1-14A Conveyor Belt foundation. The Conveyor foundations were founded on the natural inclined slope which passes through rugged topography and faces frequent slope stability problems. The study identified and analyzed the stability of slope by determining the geological and geotechnical properties of materials which compose the critical slope section. Detailed field work was done to collect a sample for laboratory tests such as moisture content, grain size analysis, Atterberg limit, compaction test and direct shear test. Based on the field manifestations and secondary data from different sources the critical slope section was identified for stability analyses. The slope stability analysis was made by three-dimensional finite element method, Rocscience based RS3 software. The slope stability analyses in terms of safety factor for both dry and saturated condition were analyzed. The analyzed results showed that, for saturated conveyor belt with rock-socketed pile, the factor of safety was 1.648 and stable. Even though, the factor of safety was stable, it was deducted from 3.698 for dry condition to 1.648 for saturated condition. Therefore, the stability of rock-socketed pile on inclined slope was highly depending on the raising of ground water table in the rainy season. Based on the identified slope stability governing factors, the proper drainage system such as surface drainage (i.e. furrows and ditches) which can prevent infiltration of rainfall and flood into the slope and subsurface drainage (i.e. horizontal and inclined drain pipe) which reduce the raising of groundwater was recommended. The stability of pile foundation in terms of bearing capacity, settlement, lateral resistance and pull-out capacity of grouped pile were analyzed using RSPile software and hand calculations. The analyzed results showed that, the pile foundation was safe against bearing capacity and uplift failure. The maximum displacement of grouped pile was less than the maximum permissible displacement and the maximum lateral deflection was less than the permissible lateral deflection allowed for grouped pile.
LINC00520 promotes breast cancer development by low expression as a tumor suppressor and prognostic biomarker by regulating the ESR2 expression level: integrated systems biology bioinformatics and experimental analyses
Authors: Ezzati Ehsan , Mosadeghi Safiye , Akbarinia Aliasghar , Horriat Soroor , Rezaei Mohammad , Azadeh Mansoureh
Published: August 2022

Background
ESR2 can have a remarkable effect on the proliferation and tumorigenesis of breast cancer (BC) as a hub tumor suppressor by regulating the effect of estrogen. The abnormal changes in the expression of the co-expressed lncRNAs can have a regulatory effect on the ESR2 expression and cause BC status. In this research, the expression and correlation of ESR2 and a related lncRNA (LINC00520) were examined through different statistical methods.
Method
An integrated bioinformatics analysis was performed to obtain a reasonable prediction about the relation of potential biomarkers and design an experiment. Based on the Microarray data analysis, pathway enrichment, GO, and ceRNA interaction analyses, a collection of RNAs was selected for the real-time PCR experiment. Several statistical methods were performed to evaluate the difference in the expressions in the BC samples, correlation of RNAs, and the possibility of being prognostic and diagnostic biomarkers (ROC and clinicopathological analysis).
Result
It is demonstrated that ESR2 (logFC: -1.842, P. Value < 0.0001) and LINC00520 (logFC: -2.231, P. Value < 0.0001) are the two robust breast cancer potential tumor suppressor in BC population. Likewise, it is demonstrated that the expression of these two RNAs has a significantly positive correlation in tumor samples (r: 0.7, P. Value: 0.0008). ESR2 (AUC: 0.9775, P. Value < 0.0001) and LINC00520 (AUC: 0.8450, P. Value: 0.0002) are the two potential diagnostic biomarkers of BC. Furthermore, expression of LINC00520 has a significant correlation with the stage (stage II) and tumor size (less than 5 cm) in the BC patients.
Conclusion
It is highly possible that the abnormal changes in the expression of LINC00520 can significantly help BC development by affecting the expression of ESR2 and playing a tumor suppressor role in Isfahan BC population. Furthermore, LINC00520 could be considered as a significant prognostic (clinicopathological analysis) and diagnostic (ROC analysis) biomarkers of BC.
Analysis of the Curative Effect and Survival Difference of Three Different Surgical Methods for Bladder Cancer Patients with Radical Cystectomy and Ureterostomy
Authors: Ma Qiyue , Yang Xiaoming , Yang Yang , Yi Chengzhi , Wei Xiaosong , Fang Zhiwei , Song Dongkui
Published: August 2022

Background: Bladder cancer is one of the most common urinary tract tumors. At present, for the treatment of invasive muscular bladder cancer or high-risk non-invasive muscular bladder cancer, radical cystectomy, urinary diversion and pelvic lymph node dissection are the preferred methods. Ureterostomy is one of the commonly used surgical procedures for postoperative urinary diversion. Open radical cystectomy (ORC), laparoscopic radical cystectomy (LRC) and robot-assisted laparoscopic radical cystectomy (RARC) are common radical cystectomy methods commonly used by urologists. Methods: In this study, patients with bladder cancer were treated with 3 different surgical methods, and the postoperative efficacy was compared, and the survival difference was analyzed. Results: Our results showed that LRC and RARC were significantly superior to ORC in intraoperative and perioperative observation indexes, and LRC and RARC could more completely remove tumors compared with ORC in complex cases. However, the survival time after ORC was longer than that of LRC and RARC patients. Conclusion: Operation methods, tumor staging, pathological grade, and number of lymph nodes dissected are all independent factors affecting patient survival, which should be paid more attention to clinically.
Comparing Students’ Perceptions on Quality of School Life: Voices from Malay and Chinese Ethnic Students
Authors:   School of Educational Studies, Universiti Sains Malaysia, 11800 USM Pulau Pinang, Malaysia, Thien Lei Mee , Low Hui Min ,   School of Educational Studies, Universiti Sains Malaysia, 11800 USM Pulau Pinang, Malaysia, Jamil Hazri ,   School of Educational Studies, Universiti Sains Malaysia, 11800 USM Pulau Pinang, Malaysia, Ahmad Mohammad Zohir ,   School of Educational Studies, Universiti Sains Malaysia, 11800 USM Pulau Pinang, Malaysia,   Faculty of Human Sciences, Universiti Pendidikan Sultan Idris, 35900 Tanjung Malim, Perak, Malaysia
Published: August 2022

While the quality of school life is expected to be cultural and context-specific, fewer studies have been conducted to investigate the conceptualisation of quality of school life in a multi-ethnic and multicultural context. This study aims to compare Malay and Chinese primary school students’ perceptions on the quality of school life in Malaysia. This study employed a quantitative cross-sectional survey research design. Survey data were collected from 594 Grade 5 students. Findings revealed that both Malay and Chinese students ranked the highest score on the opportunity dimension and the lowest scores on the negative affect dimension. The Malay students scored higher means in all dimensions of quality of schools than the Chinese students, except the findings revealed cultural differences in the perceptions of quality of school life.
From Children’s Direct Nature Experiences to Conservation Willingness: Mediating Effects of Biodiversity Knowledge and Affective Attitudes
Authors:   School of Educational Studies, Universiti Sains Malaysia, 11800 USM Pulau Pinang, Malaysia, Abdullah Faruhana ,   Faculty of Engineering, Science and Technology, The Maldives National University, Ameenee Magu Malé, 20405 Maldives, Ahmad Mohammad Zohir ,   School of Educational Studies, Universiti Sains Malaysia, 11800 USM Pulau Pinang, Malaysia,   Faculty of Human Sciences, Universiti Pendidikan Sultan Idris, 35900 Tanjung Malim, Perak, Malaysia, Ishak Nor Asniza ,   School of Educational Studies, Universiti Sains Malaysia, 11800 USM Pulau Pinang, Malaysia
Published: August 2022

Childhood direct nature experiences (DNEs) are crucial to create lasting relationships with nature that will in turn influence long-term biodiversity conservation. However, as children increasingly become urbanites, they also get progressively separated from nature. A loss DNEs of is worrisome because it can influence conservation willingness (CW) in multiple ways that are not fully understood. This study aimed to examine the serial mediation of biodiversity knowledge (BK) and affective attitudes (AA) in the relationship between DNE frequentness and CW. Data was gathered using an online survey questionnaire administered to 429 11–12 years old schoolchildren in the Maldives. A two-serial mediation analysis confirmed an underreported, predictive sequential pathway from DNEs through BK to AA to CW. Also, DNE frequentness exerted positive direct effects on BK and AA. While BK exerted neither significant direct nor independent mediating effects on CW, AA exerted both effects on CW. The direct effects of BK on AA are vital to re-orient innate, misconstrued, or biased negative attitudes to promote CW. Overall, DNE frequentness has positive effects on CW due to indirect effects rather than direct ones. The findings have implications for educators and other stakeholders to facilitate appropriate, contextually meaningful DNEs that enhance understanding of BK and stimulate positive shifts in attitude as a means to promote CW. This is an indispensable step towards successful education for sustainable development and long-term biodiversity conservation.
Students’ Adaptability on Unexpected Transition to Online Learning during COVID-19 Pandemic: The Role of Self Regulation Learning and Self Efficacy
Authors:   Faculty of Business and Finance, Universiti Tunku Abdul Rahman, 31900 Kampar, Perak, Malaysia, Awee Azeyan , Mohsin Farhana Hanim ,   Faculty of Business and Finance, Universiti Tunku Abdul Rahman, 31900 Kampar, Perak, Malaysia, Kuek Thiam Yong ,   Faculty of Business and Finance, Universiti Tunku Abdul Rahman, 31900 Kampar, Perak, Malaysia
Published: August 2022

Students and lecturers are mostly accustomed to the physical learning environment in the classroom. The transition to online learning requires quick adaptation, and students often face challenges which cause hindrance in their learning. This paper aims at highlighting students’ adaptability in online learning which can help university students and management to respond effectively to the variable factors, namely, self-regulation and self-efficacy. Based on the social cognitive theory of motivation, this study examines the relationships between students’ self-regulation, self-efficacy and adaptability in online learning. Self-efficacy is examined as a mediator and moderator variable in the relationship between self-regulation and students’ adaptability. The samples comprised of 238 students from private universities in Malaysia through a survey questionnaire. Partial least squares-structural equation modelling (PLS-SEM) was used to test the hypotheses. The results showed a direct and positive relationship for all direct relationships between variables. In addition, self-regulation and students’ adaptability is significantly mediated by self-efficacy. However, in this study, the moderator analysis found no support. This study provides theoretical and practical implications to gain a better understanding of students’ adaptability in online learning and proposed intervention for higher education institution to address and promote self-regulation and self-efficacy among students. By implementing such interventions, it is hoped that students are better able to adapt, stay motivated and in getting the most out of online learning.
Contemporary Practices in Teaching 21st Century Skills at Malaysian Primary Schools: Do Environmental Factors and Teacher’s Attitudes Matter?
Authors:   School of Educational Studies, Universiti Sains Malaysia, 11800, USM Pulau Pinang, Malaysia, Chun Tiew Chia , Abdullah Melissa Ng Lee Yen ,   School of Educational Studies, Universiti Sains Malaysia, 11800, USM Pulau Pinang, Malaysia
Published: August 2022

The implementation of 21st century education is a key factor for successful education reform. Due to a lack of empirical research, practices to develop students’ 21st century skills at the primary school level are still unclear. The purpose of this study was to identify teachers’ contemporary practices and the influences of environmental factors as well as teachers’ attitudes on these practices. A quantitative research design was used to achieve the objectives of the study. A total of 400 primary school teachers from the state of Penang, Malaysia was sampled. Three instruments were used to collect the required data; the Teachers’ Practices in Teaching 21st Century Skills Questionnaire (37 items), Environmental Factors in Teaching 21st Century Skills Questionnaire (12 items) and the Teacher’ Attitudes in Teaching 21st Century Skills Questionnaire (35 items). The data were analysed with descriptive analysis and structural equation modelling (SEM). The results showed that primary school teachers adopted five contemporary practices in teaching 21st century skills. The inquiry-based instructional approach was the most preferred practice, followed by the communicative language teaching approach, constructivist learning approach and problem-centred instructional approach. The technology-based instructional approach, however, was the least preferred practice. Results of the Partial Least Square Structural Equation Modelling (PLS-SEM) approach showed that supporting environmental factors had positive influence on both teachers’ practices and attitudes. Additional results indicated positive mediation role of teachers’ attitudes on their practices of teaching 21st century skills. Implications for the research findings were discussed in this study. As supported by the Stimulus-Organism-Response (SOR) Theory, this study found that environmental factors could drive teachers’ adoption of contemporary practices. In addition, teachers’ attitudes have positive effect on their applications of these instructional practices as emphasised by the Theory of Planned Behaviour. Educational implications and suggestions for future research are also discussed in this paper.
A Challenge of Online Teaching and Learning Pedagogy: Fundamental English Writing Class in a Thai Context
Authors:   Business English, Rattana Bundit University, Bangkapi Campus, 306, Soi Ladprao 107, Klong chan, Bang Kapi Bangkok 10240 Thailand, Inkaew Manachai
Published: August 2022

Due to the COVID-19 pandemic during 2019-2021, most teaching and learning classes in Thailand were conducted through online platforms, including the fundamental English writing course for the non-English-majoring undergraduate students. This paper aims to shed light on how the undergraduates perceive themselves while experiencing the online fundamental English writing class. In addition, this study explores students’ learning performance through results drawn from writing assignments and tests, including the learners’ reflections on their improvement in English writing. The research also examines specific factors that fostered students’ satisfactory learning outcomes throughout the online learning period. A mixed-method approach, comprising quantitative and qualitative strategies, was applied in seeking answers to the research questions. The analysis and interpretation of research data involved transforming qualitative themes or codes into numbers to triangulate the quantitative outcomes and interpreting them to explain phenomena emerging from the study. The findings suggest that students were content with the teaching and learning strategies employed throughout the course. They perceived they could improve their English writing skills and earn additional benefits from the designed online course compared with traditional in-class learning. The results of this research on the first-hand experience could be utilised as a guideline in preparing an online class, developing learning materials, and adopting or adapting helpful teaching strategies to deliver the fundamental English writing class through the online platform efficiently.
Measurements of sub-jet fragmentation with ALICE
Authors: Mulligan James
Published: August 2022

High-energy jets offer rich opportunities to study quantum
chromodynamics, from investigating the limits of perturbative
calculability to constraining the emergent properties of the quark-gluon
plasma (QGP). In these proceedings, we present new measurements of the
fragmentation properties of jets. We report distributions of the sub-jet
momentum fraction z_rzr
measured in pp and Pb–Pb collisions with ALICE at the Large Hadron
Collider. These measurements serve as input to test the universality of
jet fragmentation in the QGP, and offer a path to elucidate jet
quenching effects in the large-zz
region.
CECL3.7 H2O CATALYZED FRIEDLANDER SYNTHESIS OF QUINOLINES UNDER SOLVENT-FREE CONDITIONS
Authors:   Department of Chemistry, Chaitanya (Deemed to be University), Hanamkonda, Telangana State-506001., Shireesha Kavati , Swamy J. Kumara ,   Department of Chemistry, Chaitanya (Deemed to be University), Hanamkonda, Telangana State-506001.
Published: August 2022

The Friedlander condensation of 2-aminobenzaldehyde 1 with various carbonyl compounds containing Î±-methylene group 2 in the presence of catalytic amount of reusable catalyst CeCl3. 7H2O in solvent-free grinding conditions at RT furnished the corresponding quinolines 3 (Scheme I). The development of new methods with greater efficacy, straightforward procedures and better yields still is desirable.
THE EFFECTIVENESS OF THE ADVANCE PROJECT LEARNING (APL) MODEL TO IMPROVE STUDENTS MULTIREPRESENTATION ABILITY IN CHEMISTRY LEARNING AT PUBLIC HIGH SCHOOL
Authors:   Department of Post Graduate Science Education, Jember University, East Java, Indonesia., Kurniasari Teny ,   SMAN Balung, Jember, East Java, Indonesia., Ketut Mahardika I. ,   Department of Post Graduate Science Education, Jember University, East Java, Indonesia.,   Department of Doctoral Science Education, Jember University, East Java, Indonesia.,   Department of Physics Education, Jember University, East Java, Indonesia.,   Department of Science Education, Jember University, East Java, Indonesia.
Published: August 2022

The background of this research is not optimal Chemistry learning in public high school because students still have difficulty in understanding the abstract chemistry . The lack of interest and motivation of students towards Chemistry subjects is a major problem to be solved. With the increasing ability ofmultirepresentation, students can more easily learn chemistry . The purpose of this study is to determine the effectiveness of the Advance Project Learning (APL) model to improve the ability of multirepresentation of students in learning chemistry in public high school. The research model used inthis study is Research and Development using Borg and Gall design which includes ten steps, namely preliminary study, planning, initial product development, limited test, revision of limited test results, large group test, revision of field trial results, feasibility test, revision of results feasibility test, dissemination and implementation. The results showed that the APL model is an effective model to improve the ability of multirepresentation.
LIBRARY AND INFORMATION NETWORKS -AN OVERVIEW (MAJOR NATIONAL AND INTERNATIONAL NETWORKS)
Authors:   Assistant Librarian, University Library, Karnataka State Law University, Hubli-580020 Karnataka, India., P. Hakkaraki Vinayak
Published: August 2022

This article describes the basic concepts of library networks, objectives of library networks, need of library networking and coverage of networks, major Library networks in India, such as ADINET, DELNET, INFLIBNET, MANLIBNET, MALIBNET and other countries, such as AARLIN, CALIS, JANET, JISC, OCLC, and RLG. The reason of this article is to encourage librarian to rethink library networking and sharing, cooperation, and overall execution.
QUANTITATIVE APPROACH OF CARBONATES, CALCITE AND DOLOMITE FROM THE TARFAYA, Z3 AND Z4 OIL SHALE LAYERS BY ACID ATTACK (MOROCCO)
Authors:   Department of Chemistry, Faculty of Sciences Ben msik Casablanca, University Hassan II Morocco., Mokhlis Hafida , Attaoui Abdeljabbar ,   Department of Chemistry, Faculty of Sciences Ben msik Casablanca, University Hassan II Morocco.
Published: August 2022

The carbonates of the oil shale calcite CaCO3 and dolomite CaMg(CO3)2 were the object of this study to determine their percentage inside the oil shales. Work has been carried out in the same context (A.Attaoui and H.Mokhlis:2022) for the Tarfaya shale layers Z0, Z1 and Z2. However, the Z3 and Z4 layers present a migration of matter: the light organic matter is found in the Z3 layer and the heavy one is present in the Z4 layer, and the heavy organic matter consumes more acid in the attack reaction than the light organic matter for the same mass, which is why it is necessary to follow the decomposition of this organic matter isothermally, especially at 500Ã‚Â°C. Therefore, by combining the two reactions and by choosing well-defined isotherms (500Ã‚Â°C, 600Ã‚Â°C, 700Ã‚Â°C and 800Ã‚Â°C) we were able to approach the percentages of calcite and dolomite in these particular layers showing the phenomenon of in situ pyrolysis. The techniques used are isothermal combustion followed by HCl acid attacks and return dosing of the acid remaining after the attack. The objective of this study, which is done in return dosing using the Tacussel pH meter, is to establish a table of compositions in mass percentages of calcite and dolomite, which are the constituents of the carbonate of the Tarfaya oil shale (Morocco). Calcite CaCO3 is taken as a control; it was used under the same conditions as the oil shale, i.e. combustion in an isothermal regime, followed by acid attack.
Issues of therapy for post-acne post-inflammatory hyperpigmentation
Authors: Kruglova L. S. , Gryazeva N. V.
Published: August 2022

Introduction. Post-acne post-inflammatory hyperpigmentation most often develops in patients with moderate to severe acne. Post-acne pigmentation can be persistent and last from months to several years, which has a negative impact on the patients’ quality of life. It occurs at any age with the same frequency in men and women.

Aim. To evaluate the effect of dermatocosmetic products – a triple effect serum (containing thiamidol, salicylic acid and lycochalcone A) and SPF30 fluid for problematic skin on the skin condition in patients with moderate and severe post-acne post-inflammatory hyperpigmentation.

Material and methods. A total of 57 patients with post-acne post-inflammatory hyperpigmentation localized on the facial skin were under observation. The age of the patients was 22.4 ± 2.7 years. 32 patients were diagnosed with mild post-acne PIH, 25 patients – with moderate post-acne PIH. All patients used dermocosmetic products such as the triple effect serum (containing thiamidol, salicylic acid and lycochalcone A) and SPF30 fluid for problematic skin. Efficacy was evaluated with due account for mexametry findings, GSS, dermatology life quality index. Digital data were processed using standard medical statistical methods: calculation of the arithmetic mean value (X), square deviation (σ), Student’s t-test (t).

Results. After 12 weeks the mexometric index decreased: 92.7 and 85.9% in mild and moderate post-acne PIH, respectively. The DLQ index reduced by 84.9 and 83.8% by the end of the treatment,

Conclusions. The use of innovative dermocosmetic products containing salicylic acid and licochalcon A effectively reduces post-acne pigmentation. All patients noted good organoleptic properties: skin application comfort and excellent tolerability of the products.
Üstün Yetenekli Öğrencilerin Karakter Gelişimleri ve Karakter Eğitimine İlişkin Öğretmen Görüşleri
Authors: LEVENT Faruk , BAŞ Şeyda
Published: August 2022

Giriş: Okulların amaçlarından biri de öğrencilerin karakter gelişimini desteklemek ve onlara karakter eğitimi vermektedir. Yaşıtlarından farklı özellik ve ihtiyaçlara sahip olan üstün yetenekli öğrencilere karakter eğitimi, bu öğrencilerin sosyal ve duygusal iyi oluşlarını olumlu yönde etkilemektedir. Bu çalışmanın amacı, üstün yetenekli öğrencilerin karakter gelişimleri ve karakter eğitimine ilişkin öğretmen görüşlerinin incelenmesidir.Yöntem: Bu çalışma, nitel araştırma yöntemlerinden olgubilim deseni ile gerçekleştirilmiştir. Araştırmanın çalışma grubu, amaçlı ölçüt örnekleme yöntemiyle belirlenmiştir. Çalışmanın amacına uygun olarak, üstün yetenekli öğrencilerle çalışan 15 öğretmenle görüşme yapılmıştır. Bu çalışmada veri toplamak için nitel veri toplama yöntemlerinden yarı yapılandırılmış görüşme tekniği kullanılmıştır. Elde edilen veriler içerik analizi ile çözümlenmiştir.Bulgular: Verilerin analizi sonucunda; üstün yeteneklilerin özellikleri ve ihtiyaçları, üstün yetenekli öğrencilerin karakter gelişimi ve bu öğrencilere karakter eğitimi olmak üzere üç temaya ulaşılmıştır. Üstün yetenekli öğrencilerin özellikleri ve ihtiyaçları temasında hızlı öğrenme/kavrama kodunun öne çıktığı görülmektedir. İkinci temada, katılımcı öğretmenlerin bir kısmı, üstün yetenekli öğrencilerin karakter gelişiminde akranlarından daha önde olduğunu, katılımcıların bir kısmı ise bu öğrencilerin akranlarına göre geride kaldıklarını belirterek iki farklı görüş ortaya koymuştur. Üçüncü temada katılımcı öğretmenlerin çoğu, Milli Eğitim Bakanlığı (MEB) tarafından uygulanan değerler eğitimi programının üstün yeteneklilerin karakter gelişimi için yetersiz olduğunu belirtmiş ve uzaktan eğitim yoluyla karakter eğitiminin verimsiz olduğunu ifade etmiştir.Tartışma: Okullarda üstün yetenekli öğrencilerin eğitiminde karakter eğitiminin ihmal edilmesi büyük bir eksiklik olarak kabul edilmektedir. Bu araştırmada elde edilen bulgular doğrultusunda, üstün yetenekli öğrencilerin ihtiyaçlarına ve özelliklerine uygun olarak karakter eğitimi programlarının hazırlanması gerektiği söylenebilir. Ayrıca MEB merkez örgütü tarafından üstün yetenekli öğrencilerin karakter eğitimine ilişkin öğretmenlere ve okul yöneticilerine yönelik hizmet içi eğitimlerin düzenlenmesi önerilebilir.