bluuebunny/crossref_metadata_2025 huggingface dataset:
Formation conditions of the Lover Kasimovian (Upper Carboniferous) organic buildups on the Ilych River (Northern Urals)
Authors:   Institute of Geology FRC Komi SC UB RAS, Ponomarenko E. S.
Published: December 2020

Lower Kasimovian organic buildups in the Moleben-Iz section on the Ilych River, Northern Urals, were studied. Two levels of buildups development have been established, that are composing by algal and palaeoaplysinid boundstones and biocementstones. They are probably a part of long (up to 10 km) and complexly constructed biostromes. Lithological data indicate the formation of these buildups in the normal marine sutidal conditions on the carbonate ramp.
Efeitos de oficina educativa sobre prevenção e cuidados à criança com engasgo: estudo de intervenção
Authors: Costa Priscila , Silva Leticia Soares , Silva Mariah Tomé , Floriano Claudia Maria de Freitas , Orsi Kelly Christina Sbampato Calado
Published: December 2020

Objetivo: Avaliar o efeito de uma oficina educativa sobre prevenção e cuidado à criança com engasgo no conhecimento de profissionais da saúde e da educação infantil. Métodos: Estudo quase-experimental com pré e pós-teste, e abordagem quantitativa conduzido em um centro assistencial filantrópico e uma escola de educação infantil. A intervenção foi composta, por oficina educativa teórico-prática, sobre prevenção e atendimento à criança com engasgo. O conhecimento dos participantes foi avaliado, por meio de questionário com nove itens antes e depois da intervenção. Resultados: Participaram do estudo 36 indivíduos, sendo 22 profissionais da educação infantil e 14 profissionais da saúde. Verificou-se aumento de 29,9% no conhecimento dos participantes após a oficina. A média de acertos no questionário passou de 5,7 para 8,3 com diferença significativa (p
Caracterização de pacientes sob cuidados paliativos submetidos à punção venosa periférica e à hipodermóclise
Authors: Moreira Michele Rocha , De Souza Ana Carolina , Villar Jéssica , Bolela Fabiana , Viana Angelina Lettiere , Pessalacia Juliana Dias Reis
Published: December 2020

Objetivo: caracterizar os pacientes oncológicos internados sob cuidados paliativos submetidos à punção venosa periférica e a hipodermóclise, segundo as variáveis sociodemográficas e clínicas. Método: estudo observacional, descritivo e prospectivo. Foram realizadas entrevistas com o paciente e/ou seu cuidador, consulta ao prontuário, avaliação e acompanhamento diário da punção. Resultados: participaram do estudo 45 pacientes de ambos os sexos e com idade superior a 18 anos. A avaliação funcional dos pacientes, no momento da internação, foi de 30%, indicando pacientes extremamente incapacitados e com necessidade de hospitalização. Os sintomas mais frequentes apresentados pelos pacientes no dia da internação foram inapetência, sonolência, fadiga, dispneia e dor. O número de punções venosas periféricas foi superior ao número de hipodermóclises realizadas. Conclusão: os dados analisados permitiram caracterizar o perfil de pacientes oncológicos internados sob cuidados paliativos e a terapêutica adotada para a terapia medicamentosa. Pôde-se, ainda, identificar a baixa adesão da equipe à realização da hipodermóclise, o que remete à necessidade da realização de mais estudos com altos níveis de evidência para embasar a prática assistencial da equipe de enfermagem e contribuir para a qualidade de vida do paciente.
Caracterização dos episódios de queda em uma unidade de cardiologia: estudo retrospectivo
Authors: Sousa Andreia Lima de , Monteiro Ana Carolina Lici , Ambiel Maria Letícia Banwart Ribeiro , Ferreira Elaine Barros , Rocha Priscilla Roberta Silva
Published: December 2020

Objetivo: Caracterizar os episódios de queda em pacientes internados em uma unidade cardiológica, quanto à ocorrência, fatores relacionados e risco. Método: Estudo descritivo, retrospectivo, por meio da análise de prontuários de pacientes internados em uma unidade de cardiologia que apresentaram episódio de queda entre janeiro de 2015 a dezembro 2016. O risco médio para quedas foi avaliado, conforme a Escala de Morse. Resultados: No período de estudo houve 32 episódios de quedas. A queda foi mais frequente em idosos (81,3%) e naqueles que faziam uso crônico de medicamentos, para controle e tratamento de comorbidades preexistentes. Dentre os fatores de risco, 34,4% apresentavam delirium, comprometimento neurológico e déficit de locomoção. O risco médio para quedas foi classificado como elevado (> 45), 25% das quedas resultaram em algum tipo de dano (leve ou moderado) e ocorreram em períodos matutinos. Conclusão: As contribuições fornecidas pelos registros de eventos adversos, deste estudo, facilitaram a identificação dos fatores de risco, demonstrando a necessidade de se propor intervenções de enfermagem preventivas, uma vez que assumir o evento e identificar suas causas são maneiras de praticar uma assistência de enfermagem segura ao paciente.
Seletividade punitiva, racismo e superencarceramento no Brasil
Authors: Kilduff Fernanda
Published: December 2020

The purpose of this article is to analyze racism and social inequality as foundations of over-incarceration in Brazil. The first section discusses the relationship between punitive selectivity and structural racism from a historical perspective. This is followed by an analysis of the relationship between the downgrading of the population's living conditions through the process of neoliberal counter-reforms and the increase in incarceration and naturalization of dehumanizing practices in the prison environment. The third section presents notes on the increase in female incarceration in Brazil for the crime of drug trafficking. The final remarks highlight that, in the neoliberal phase of capitalism, the structural racism that permeates the criminal justice system finds renewed arguments in the “war on drugs”, to legitimize the over-imprisonment of women, poor and black women in particular. The results indicate that the selective criminal logic reiterates the conditions of oppression from the perspective of gender. Women are doubly punished: by the criminal justice system and by the conservative morality that underpin patriarchal oppression. The method used in the analysis is the materialist-dialectic. From the perspective of social totality, we aim to capture the complex and multiple determinations that constitute the object of study. The research methodology is based on literature and document reviews.
O recrudescimento penal em meio a pandemia do coronavírus no Rio de Janeiro
Authors: Fernandes Ionara Santos
Published: December 2020

Criminal policy takes on new shapes in Rio de Janeiro during the new coronavirus pandemic. The State expresses its ultra-conservative and punitive approach to manage the public health crisis in the precarious prison system, reducing the law and expanding the prison economy. The purpose of this text is to reflect on some elements introduced and / or reaffirmed during the pandemic in the prison system, such as the increase in family expenses, which with suspended visits, deliver more food and money, the voluntary work carried out by prisoners in the mass production of masks. and the consideration of the use of containers and alteration of prison architecture rules. As a methodology, the study used documents produced by MEPCT / RJ (institution that monitors and inspects places of deprivation of liberty in the state), and presents evidence to think of new dynamics in prison, along with a relevant review of literature to reflect on the issue. The paper also identifies the instrumentalization of the world health crisis for the agenda of criminal recrudescence in Brazil, guaranteeing profitability and capital reproduction.
Migração Internacional no Brasil: persistências históricas e tendências contemporâneas
Authors: Dias Áurea Cristina Santos
Published: December 2020

The increase of enforced displacements in the world has been highlighted by data from international organizations. This article contextualizes contemporary international migration in Brazil as one of the multiple phenomena related to the impetus of capitalist expansion, especially since the early 2000s, when border immigration of nationalities such as Haitian, Congolese, Bengali and Senegalese have accelerated. Based on bibliographic references and document analysis, we discuss that, despite having achieved a recognized advanced legislation related to refuge and a recent migration law, in Brazil, the State management of the migratory issue is much more related to control and selectivity through extraordinary legal mechanisms, than through guarantees; This has led to a process of inclusion and exclusion of immigrants that goes back to the previous history of Brazilian migratory policy and aligned with international discourse and practices, with growing perspective of immigration being a security and criminalizing issue. As of 2016, the Brazilian departure from international commitments to protect the human rights of migrants has become evident, causing specific situations in the daily lives of these subjects, such as the absence or difficulty of access to health care services, as well as the perpetuation of the situation of provisional or undocumented migration.
Violência do Estado e expropriação das populações indígenas no Brasil contemporâneo: terra, território, trabalho e criminalização da Questão Social
Authors: Berger William
Published: December 2020

This article presents the indigenous problem as representative of the social issue in the Brazilian economic, social and spatial formation, as well as its expressions in contemporary times. The categories of land and territory, based on the centrality of work, are used as historical foundation of uneven and combined development. Since the formation of dependent capitalism in Latin America, under the exploitation and oppression of indigenous and black roots, the sense of slavery colonization has been perpetuated, a process marked by deep State violence with expropriation and overexploitation of the traditional peoples of the region. Expropriation is emphasized in the current urban context, with the continuous process of expelling these people from their lands, criminalization and theft of rights, in a supposedly democratic society. Land, territory and work are, therefore, three founding categories of the social issue in Latin America, which can only be understood from the centrality of the agrarian question.
População em situação de rua e as respostas do Estado nas tramas da cidade capitalista
Authors: Freitas Renata Martins de
Published: December 2020

It is visible, in everyday life in big cities, the increasing number of people living on the streets, reproducing their lives in the open, and exposing the great contradictions of the capitalist system that generates inequality, pauperism and barbarism. This article aims at understanding “phenomenon” as an expression of the “social question” within contemporary capitalist society, its features and the responses of the State in the plots of urban settings. It is based on a historical and critical analysis of widespread research, on censuses based on the Marxist theoretical framework. The philanthropic aspect of this expression of the “social question” is identified, as well as responses based on repression and criminalization in the name of “order”, “progress” and development in cities, and the institutionalization of services and rights aimed at these people in recent years.
The Great Victory and the post-war world order (from the League of Nations to the UN)
Authors: Ruban Larissa S. , Qu Wong
Published: December 2020

The author shows how the post-war world order was formed and what role the countries that were allies of the anti-Hitler coalition (the Soviet Union, the United States, and the United Kingdom) played in this process. The development of the Charter and procedures for the activities of the United Nations, which took place at the meeting Stalin, Roosevelt and Churchill at the Yalta conference in February 1945 in the Crimea, is discussed in detail. Describing the current situation in the context of globalization, the author leads the discussion of Russian and foreign scientists about the vision of the modern world.
Integration of Italian populist parties into the political system: participation in the development of electoral laws
Authors: Beryozkina Elena Yu.
Published: December 2020

The article analyzes the participation of the populist parties of Italy “League of the North” and “5 Star Movement” in the development of electoral legislation and the distribution of parliamentary mandates in recent electoral cycles. The author considers their participation in lawmaking as part of an inter-party competition.
Risks of demographic development in a pandemic
Authors: Sigareva Evgenia P. , Sivoplyasova Svetlana Yu. , Pletneva Julia E.
Published: December 2020

In the article, the authors consider various theories of “risk” in the context of the formation of a new reality, which is characterized by different criteria and degrees of uncertainty. Researchers analyze the works of W. Beck, E. Giddens, M. Douglas, N. Taleb, F. Hoffman and others. The article provides a deep analysis of the risks of Russia’s demographic development in the context of a global pandemic. Based on the results of their own research, based on the data of a set of methods for collecting and analyzing information, the authors of the article come to the following conclusions. The first and then the second wave of depopulation makes the demographic determination of the development of the Russian state a priority, which requires a revision of the paradigm of the economic perspective. Under these conditions, the risk of a decline in the global population will increase many times over. Against the background of the development of negative global and domestic demographic processes and the formation of apocalyptic views on the future, the “pandemic” damage to the population can become only an insignificant contribution to this trend. It is necessary to monitor not only possible risks, but also the reaction of the population to the preventive measures proposed by the state, combating the pandemic, as well as socio-economic support of citizens and entrepreneurs in the difficult conditions of the spread of COVID-19.
Diversity, Abundance, and Distribution Patterns of Natural Enemy Insects on Chili (Capsicum annum L.) in Bincau Village, Banjar Regency, South Kalimantan
Authors: Trianto Manap , Marisa Fajri , Kisman Moh Dahri
Published: December 2020

Chili is a widely cultivated plant by the community because of its profit. Currently, in maintaining the quality of chili, people commonly use a lot of pesticides. In contrast, naturally, there are biological agents in the shape of natural enemy insects, more effective, and environmentally friendly. This study aims to determine the diversity, abundance, and distribution patterns of natural enemy insects in chili plantation (Capsicum annum L.) at Bincau Village, Martapura District, Banjar Regency, South Kalimantan. The sample is collected by pitfall trap, yellow pan trap, and sweep net method. Obtained data are analyzed by Shannon Wienner index (H'), Meyer abundance index, Morisita index (Id), and PCA method for environmental parameter analysis. The results showed the diversity of natural enemy insects on chili plants was moderate (H' = 2.396). Furthermore, the highest abundance in research is demonstrated on Hymenoptera order, which consisted of 9 families, 16 species, and 1,009 individuals. The distribution pattern of natural enemy insects in chili plantations is clustered (Id > 1). Based on the PCA analysis method, the temperature has the most impact on natural enemy insects' presence in this study.
Preliminary Detection of Antibacterial Activity of Fishpond Water Bacteria against Aquaculture Pathogenic Bacteria
Authors: Magdalena Stella , Sindy Sindy , Yogiara Yogiara
Published: December 2020

Aquaculture is currently experiencing massive loss due to the outbreak of pathogenic bacteria. One of the outbreak causes is the development of pathogenic bacterial resistance to the antibacterial. The problem can be solved using microorganisms that can produce new antibacterial compounds. The purpose of this research was to obtain bacteria from fishpond water that could produce antibacterial compounds. About two out of 81 isolates could produce antibacterial compounds. Those two isolates were obtained from saltwater fishponds in North Jakarta (TS2) and Harapan Island (PHY). All fishpond water was grown in marine broth or Luria broth. Extraction of antibacterial compounds was performed using four types of solvents: chloroform, dichloromethane, ethyl acetate, and methanol. Each of the solvents showed a different result. The extraction can only be successfully performed using chloroform and dichloromethane. Extraction using dichloromethane showed a larger inhibitory clear zone than chloroform. Based on 16S rRNA gene sequencing, PHY isolate was identified as Bacillus sp. and TS2 as Acinetobacter sp. In conclusion, isolate TS2 and PHY, which produced antibacterial compounds, showed potential use as aquaculture probiotics.
Kebijakan Portofolio Optimal Saham Syariah pada Indeks Saham Syariah Indonesia (ISSI) Menggunakan Model Indeks Tunggal pada Masa Pandemi Covid 19 (Periode Januari sampai dengan Juni 2020)
Authors: Wardah Baiq
Published: December 2020

This research uses a quantitative approach using descriptive methods. The population of this research is all stocks that are included in the largest market capitalization for the period January - March 2020 with a total of 50 shares. The sampling technique used in this study was purposive sampling method, so that 28 stocks were obtained as the research sample. The variables of this research are stock price, JCI, Bi 7-Day Repo Rate, Return, Risk, Selected Shares and Proportion of Funds. The data analysis method used in this study is the Single Index Model. Based on the research results, it is concluded that there are 3 stocks that meet the criteria for optimal portfolio formation and the proportion of funds for each of these stock, namely PT. Fajar Surya Wisesa Tbk. (FASW) 53.40%, 45.48% stock of PT. Bayan Resources Tbk. (BYAN) by 45.48% and stock of PT. Pollux Properti Indonesia Tbk. (POLL) by 1.12%. The implication of this research is to provide an overview or information for investors about the advantages and disadvantages of Islamic stocks during the Covid-19 pandemic.

 

Penelitian ini menggunakan pendekatan kuantitatif dengan menggunakan metode deskriptif. Populasi penelitian ini adalah seluruh saham yang masuk dalam kapitalisasi pasar terbesar periode Januari – Maret tahun 2020 dengan jumlah 50 saham. Teknik pengambilan sampel pada penelitian ini menggunakan metode purposive sampling, sehhingga diperoleh 28 saham sebagai sampel penelitian. Variabel penelitian ini adalah harga saham, IHSG, Bi 7-Day Repo Rate, Return, Risiko, Saham Terpilih dan Proporsi Dana. Metode analisis data yang digunakan pada penelitian ini adalah Model Indeks Tunggal. Berdasarkan hasil penelitian diperoleh kesimpulan, bahwa terdapat 3 saham yang memenuhi kriteria pembentukan portofolio optimal dan besar proporsi dana masing-masing saham tersebut, yakni saham PT. Fajar Surya Wisesa Tbk. (FASW) sebesar 53,40%, 45,48% saham PT. Bayan Resources Tbk. (BYAN) sebesar 45,48% dan saham PT. Pollux Properti Indonesia Tbk. (POLL) sebesar 1,12%. Implikasi dari penelitian ini adalah memberikan gambaran atau informasi bagi para investor tentang potensi keuntungan dan kerugian saham syariah pada saat masa pandemi Covid-19.
Factors Associated With Burnout Among Nurses at International Hospital Kampala (IHK)
Authors: Anita Ashaba Aheebwa , Kizito Omona
Published: December 2020

Introduction: Burnout is a psychological syndrome involving physical depletion, feelings of helplessness, negative self-concept, and negative attitudes towards work, life, and others. Burnout is a problem among health care professionals and nurses are found to be vulnerable. It is associated with a decrease in occupational well-being and increase in absenteeism, turnover and illness.Objectives: To evaluate the prevalence and factors associated with burnout among nurses at International Hospital Kampala (IHK).Methods: Analytical cross-sectional design was used. Data was collected from a sample of 120 nurses using questionnaire and Maslach Burnout Inventory (MBI) tools. Analysis was done using Statistical Package for Social Sciences and Microsoft excel.Results: The prevalence of burnout within the MBI subscales was highest in the subscale of personal accomplishment (PA) - 72.5%), followed by Depersonalization (DP) – 66.8% and Emotional Exhaustion (EE) - 61.7%. Overall prevalence of burnout among was 66.95%. Nurses with high burnout had the lowest level of personal accomplishment-18.33% while nurses with low burnout had the highest level of personal accomplishment-72.5%. Age (X2(2) =6.670, p=0.036) was associated with burnout. Respondent years in service was more highly associated with burnout (X2(2) = 10.961, p=0.004). Job satisfaction (X2(1) = 4.361, p=0.037) was associated with burnout. Emotional Exhaustion (EE) of the respondents (X2(2) =29.197, p=0.000) was associated with burnout. Many nurses, 61(50.8%) had EE and burnout. Depersonalization (DP) (X2(2) =72.803, p=0.000) was also associated with burnout. Hours worked in a day (X2(1) =72.803, p=0.016) was associated with burnout. Getting social support at work (X2(1) =72.803, p=0.016) was associated with burnout, thus 48(40.0%) of the nurses who got social support had burnout.Conclusion: The prevalence of burnout is quite high among nurses.
Acute toxicity test ethanol extract of kerehau leaf (Callicarpa longifolia Lamk) using OECD 420 method
Authors:   Universitas Bhakti Kencana, Istiqomah Aulia , Safitri Shintya , Susilawati Elis
Published: December 2020

Background: Kerehau is empirically used as cooling powder to treat acne. Based on previous research, kerehau leaves have a number of activities, including wound healing, antidiabetic, and anti-inflammatory. Objectives: This study aimed to determine the safety level of a single dose of ethanol extract of kerehau leaves within a 24-hour administration period. Methods: Acute toxicity testing of ethanol extract of kerehau leaves was carried out on female Webster mice. Test animals were divided into 4 treatment groups, consisting of 1 control group and 3 test groups. The testing method referred to OECD (Organization of Economic Cooperation and Development) 420 with modified doses of 2000mg/kgBW, 5000 mg/kgBW, and 8000 mg/kgBW. The observations were made on the behaviour of animals towards toxicity symptoms for 4 hours after administration of the test substance as well as death. The death and weight gain were observed for 14 days. On the 15th day, animals were sacrificed, blood was taken, and biochemical parameters were measured. The heart, kidneys, liver, spleen, and lungs were harvested and weighed. Data was analysed using Oneway ANOVA continued with LSD and Post Hoc. Results: The results showed that ethanol extract of kerehau leaves did not cause death in all of the groups. There were significant differences in liver weight, SGPT, and SGOT levels (p< 0.05) at the dose of 5000 mg/kgBW. No toxicity symptoms and death were found until the end of the experiment. Conclusion: LD50 value of ethanol extract of kerehau leaves was above 8000 mg/kgBW with heart as the most affected organ. Keywords: Ethanol extract of kerehau leaves, acute toxicity test, OECD 420.
Confusion, difficulty concentrating, and slow response induced by ropinirole therapy in an elderly patient with secondary Parkinsonism: a case report
Authors: Sidharta Emilia , Wijaya Ivon Sindu , Cahyadi Hanny
Published: December 2020

Background: Ropinirole is a therapy that is widely used in patients with Parkinson's disease or Restless Leg Syndrome (RLS). Some research journals show that the long-term use of ropinirole can cause side effects. But unfortunately, there are no published studies from Indonesia that show the side effects of ropinirole.. Objective: To report a case of several side effects induced by ropinirole therapy Method : Assessment methods used were time series data collection followed by causality analysis using Naranjo Scale. Results: This case reports several side effects such as confusion, difficulty concentrating, and slow response experienced by a 75-year-old elderly patient who consumed ropinirole 2 mg as a therapy for Secondary Parkinsonism. Before using ropinirole, the patient had used levodopa-benserazide, trihexyphenidyl, and pramipexole to overcome Parkinson's for more than 3 years. During the period no side effects occurred. Side effects occurred after ropinirole therapy was given to patients. The analysis using Naranjo Scale shows a score of 6 which means Probable. Conclusion: The aim of this study is to raise awareness for health workers, especially pharmacists in order to increase alertness in patients using long-term medications such as those with Parkinson's. Keywords: side effect, secondary parkinsonism, ropinirole, elderly
Dendroclimatology in Latin America, State of the Art and Contributions for Understanding Climate Variation
Authors: Sánchez Oscar D. , Mendoza Manuel E. , Carlón-Allende Teodoro , Villanueva-Díaz José
Published: December 2020

Dendroclimatology has gained relevance during the XXI century. We analyze the state of-the-art of dendroclimatology in Latin America during the past 28 years (1990 to 2019), identifying the current state and recent advances in the application of dendroclimatology in this region. We carried out a systematic review in ScienceDirect, Web of Science, and Scopus databases using Boolean operators to logically connect the keywords “dendrochronology,” “dendroclimatology,” “trend,” “climatic variability,” and “climatic variability trend”, for each country. Dendroclimatological research conducted in the region focused on climatic reconstruction and the evaluation of new tree species with dendrochronological potential, which increase in 2010, then there was a gap between 1995 and 1996, later increase to present. Dendroclimatological studies in Latin America have been mainly developed in temperate climate zones (82.4 %) followed by tropical or subtropical areas (17.6 %). Dendroclimatological research in Latin America has provided advances in the study of climate variability by defining response functions of tree rings to climate. The generated information allows for a better understanding of the spatial and temporal dynamics of climatic variability and about its effects on ecosystems and society. We also call for increased dendroclimatological research based on subtropical and tropical forests limited studied until today.
Impact of Service User Video Presentations on Explicit and Implicit Stigma toward Mental Illness among Medical Students in Nepal: A Randomized Controlled Trial
Authors: Tergesen Cori L. , Gurung Dristy , Dhungana Saraswati , Risal Ajay , Basel Prem , Tamrakar Dipesh , Amatya Archana , Park Lawrence P. , Kohrt Brandon A.
Published: December 2020

This study evaluated the impact of didactic videos and service user testimonial videos on mental illness stigma among medical students. Two randomized controlled trials were conducted in Nepal. Study 1 examined stigma reduction for depression. Study 2 examined depression and psychosis. Participants were Nepali medical students (Study 1:n=94, Study 2:¬n=213) randomized to three conditions: a didactic video based on the mental health Gap Action Programme (mhGAP), a service user video about living with mental illness, or a control condition with no videos. In Study 1, videos only addressed depression. In Study 2, videos addressed depression and psychosis. In Study 1, both didactic and service user videos reduced stigma compared to the control (F2,91=6.37, p=0.003). In Study 2 (depression and psychosis), there were no differences among the three arms (F2,210=2.07, p=0.13). When comparing Study 1 and 2, there was greater stigma reduction in the service user video arm with only depression versus service user videos with depression and psychosis (t(31)=-3.04, p=0.005). In summary, didactic and service user videos were associated with decreased stigma when content addressed only depression. However, no stigma reduction was seen when including depression and psychosis. This calls for different strategies based on types of mental illnesses.
ClinicalTrials.gov identifier: NCT03231761
The Dirac Electron Consistent with Proper Gravitational and Electromagnetic Field of the Over-rotating Kerr-Newman Black Hole Solution
Authors: Burinskii Alexander
Published: December 2020

We consider the Dirac electron as a nonperturbative particle-like solution consistent with its own Kerr-Newman (KN) gravitational and electromagnetic field. We develop the earlier models of the KN electron regularized by Israel and López, and consider the non-perturbative electron model as a bag model formed by Higgs mechanism of symmetry breaking. The The López regularization determines the unique shape of the electron in the form of a thin disk with a Compton radius reduced by 4π. In our model this disk is coupled with a closed circular string which is placed on the border of the disk and creates the caused by gravitation frame-dragging string tension produced by the vector potential of the Wilson loop. Using remarkable features of the Kerr-Schild coordinate system, which linearizes the Dirac equation, we obtain solutions of the Dirac equation consistent with the KN gravitational and electromagnetic field, and show that this solution takes the form of a massless relativistic string. Parallelism of this model with quantum representations in Heisenberg and Schrodinger pictures explains remarkable properties of the stringy electron model in the relativistic scattering processes.
Targeting BRF2 in Cancer with Repurposed Drugs Using in Silico Methods
Authors: Rashidieh Behnam , Molakarimi Maryam , Mohseni Ammar , Truong Hein , Srihari Sriganesh , Adams Rachael C. , Duijf Pascal H.G. , Kalimutho Murugan , Khanna Kum Kum
Published: December 2020

Overexpression of BRF2, the essential subunit of RNA polymerase III, is required for the development of a variety of cancers, including lung squamous cell carcinoma and breast cancer. BRF2 also acts as a central redox-sensing transcription factor (TF) and is involved in the regulation of oxidative stress (OS) pathway where its amplification enables cancer cells to evade OS-induced apoptosis. Here, we experimentally confirmed a link between BRF2 and DNA damage response (DDR) signaling. Focusing on its DNA binding capacity, we targeted BRF2-TATA binding Protein (TBP)-DNA complex interaction to functionally inhibit this transcription factor (TF). We found that BRF2 binding to TBP changes the conformation of this protein and therefore characterized these events in detail. Virtual screening allowed selection of the optimal drug based on binding energy, and intermolecular, internal, and torsional energy parameters. Molecular dynamics simulation confirmed the docking results and all simulations were validated by root‐mean‐square deviation (RMSD). According to the simulation, the chosen drug was efficacious in targeting BRF2 which therefore requires further experimental validation to investigate the effect of this drug on BRF2 functions and its downstream pathways.
Genetic Diversity of Duabanga moluccana Blume from Two Provenances in West Nusa Tenggara Revealed by Microsatellite markers
Authors: Larekeng Siti Halimah , Yusniar Yusniar , Restu Muh , Rismawati Rismawati , Cahyaningsih Yuni Fitri , Arsyad Mirza Arsiaty , Nirsatmanto Arif
Published: December 2020

Duabanga moluccana Blume, locally known as Rajumas, is a tree species that suitable for building materials, pulp, and plywood. The information about genetic diversity is required for the conserving of this species. Here, we elucidated the genetic diversity of D. moluccana from two provenances in West Nusa Tenggara, Indonesia. Four microsatellite markers successfully amplified 12 randomly selected samples and produced polymorphic DNA bands. Those primers were DMAG10, DMAG09, DMACAG01 and DMTCAC11. High genetic diversity was detected in the populations with 0.54 of mean expected heterozygosity (He). The genetic variation among individuals was 100%, whereas there were no genetic variations among populations and within individuals
Short-Term Forecasting Model of Animal Food Commodities in Central Sulawesi
Authors: Rauf Rustam Abdul , Safitri Dian , Christoporus Christoporus , Effendy Effendy , Muhardi Muhardi
Published: December 2020

Shifting patterns of community consumption from vegetable protein to animal protein encouraged high demand for animal food, so it was needed an estimate of the supply and demand for its products. Therefore, this research aimed to analyze the short-term forecasting model of the production and price of beef and broiler meat in Central Sulawesi. The research used time series data. Production data and price of beef and broiler meat were taken from 2015 - 2019. The analytical tool used was the ARIMA Box-Janskin forecasting method. The results showed a short-term forecasting model for beef production (1,0,0) and broiler meat (3,2,1). Short-term forecasting model for beef price (1,0,1) and broiler meat (1,1,1).  This finding could be used as a reference in making policies related to the production and price of beef and broilers meat in order to meet the needs of the community, especially in Central Sulawesi.
MSEICR Fractional Order Mathematical Model of The Spread Hepatitis B
Authors: Suriani Suriani , Toaha Syamsuddin , Kasbawati Kasbawati
Published: December 2020

This research aims to develop the MSEICR model by reviewing fractional orders on the spread of Hepatitis B by administering vaccinations and treatment, and analyzing fractional effects by numerical simulations of the MSEICR mathematical model using the method Grunwald Letnikov. Researchers use qualitative methods to achieve the object of research. The steps are to determine the MSEICR model by reviewing the fractional order, looking for endemic equilibrium points for each non-endemic and endemic equilibrium point, determining the equality of characteristics and eigenvalues ​​of the Jacobian matrix. Next, look for values  ​​(Basic Reproductive Numbers), analyze stability around non-endemic and endemic equilibrium points and complete numerical simulations. From the simulation provided, it is known that by giving a fractional alpha value of and  , the greater the value of the fractional order parameters used, the movement of the solution graphs is getting closer to the equilibrium point. If given and still endemic, whereas if and  the value  is increased to non-endemic, then the number of hepatitis B sufferers will disappear.
Application Of The Hybrid Method Nonlinear Regression With Modified Logistic Growth Model - Exponential Double Smoothing For Forecasting Covid-19 Cases In Indonesia And Armenia
Authors: Arez Andy Rezky Pratama Syam
Published: December 2020

Since the first cases of Covid-19 (Corona Virus Disease-19) infection were officially recognized and recorded in Indonesia on March 2, 2020 and March 1, 2020 in Armenia, the addition of new cases has not shown any indication of sloping. The relatively high number of new cases indicates that Indonesia has not yet passed the peak of the pandemic. As for Armenia, the addition of new cases indicates a new pandemic peak to be faced. In these conditions, an important question for decision makers (the Government) to find answers to is when and at what level of total cases will the COVID-19 pandemic end in Indonesia or the second wave in Armenia. Based on this, the forecasting method of Hybrid Nonlinear Regression With Modified Logistic Growth Model - Double Smoothing Exponential and Classical methods is used to predict the Covid-19 cases that occur in Indonesia and Armenia. Based on the model formed, the peak of Covid-19 cases in Indonesia is predicted to occur on November 26, 2020, with the number of cases reaching 5968 cases. As for Armenia, the peak of Covid-19 cases will occur on November 15, 2020, with the number of cases reaching 3098 cases. Covid-19 in both countries is predicted to decline and be constant in 2021. For the country, Indonesia is predicted to begin to stabilize and be controlled in July - August 2021. As for Armenia, Covid-19 is predicted to be under control and approaching 0 cases in February - March 2021.
Stability Analysis of Divorce Dynamics Models
Authors: Muaraf Syamsir , Toaha Syamsuddin , Kasbawati Kasbawati
Published: December 2020

This article examines the mathematical model of divorce. This model consists of four population classes, namely the Married class (M), the population class who experiences separation of separated beds (S), the population class who is divorced by Divorce (D), and the population class who experiences depression or stress due to divorce Hardship (H). This study focuses on the stability analysis of divorce-free and endemic equilibrium points. Local stability was analyzed using linearization and eigenvalues ​​methods. In addition, the basic reproduction number  is provided via the next generation matrix method. The existence and stability of the equilibrium point are determined from . The results showed that the rate of interaction between population M and populations other than H is very influential on efforts to minimize divorce. Divorce can be minimized when the transmission rate is reduced to . Reducing the transmission rate and increasing the rate of transfer from split bed class to married class can turn divorce endemic cases into non-endemic cases. A numerical simulation is given to confirm the analysis results.
Trust and Commitment Toward Mobile Payment Platform
Authors: Sembiring Oktyfany , Hamonangan Aruan Daniel Tumpal
Published: December 2020

With the rapid growth of online technology in financial services, Mobile Payment has becomepopular in recent years. Many studies have investigated financial innovations based oninformation and communication technology (ICT) in bank institutions. Specifically, this studyis important to explore the use of Mobile Payment provided by non-bank institutions. Thisstudy focuses on trust and commitment to improving their continuous usage intention ofMobile Payment. We argue that the advantages of Mobile Payment (Mobility, Customization,Security, and Reputation) contribute to trust and commitment. The findings of this studyillustrate that the Mobile Payment reputation has a positive effect on trust. Trust is mediatedby commitment has a positive influence on continuance intention. This study recommends thatthe topic of research needs to be explored more in order to understand and develop marketingstrategies for Mobile Payment users.
Behind The Positive Attitude of The Indonesian Army Academic Staff: A Rasch Model Analysis
Authors: Abidin Didin Zainal , Wibowo Wibowo , Sudiarditha I Ketut R. , Herlina Maria Grace
Published: December 2020

The Indonesian National Army is an integral part of the Indonesia Archipelago. As the national component, the Army has the main task of maintaining the country's sovereignty and territorial integrity of the unitary state. Therefore it needs high-quality human resources. The aim of the research was examining the real motivational factors behind the positive attitude of The Indonesian Army Academic Staff. The study applied a Rasch Model method. The Rasch Model Analysis was used to examine the research variable based on its dimensions and indicators. The research results show that team-building development process has been successfully proven, based on the research results. The Rasch Model analysis also shows that team-spirit among The Indonesian National Army members is very solid. It is the most satisfactory factor that creates positive task-attitude among the army academic staff. At the same time, the promotion is the most challenging factor to agree with among them.
Sex differences in viral entry protein expression and host transcript responses to SARS-CoV-2
Authors: Sun Mengying , Shankar Rama , Ko Meehyun , Chang Christopher Daniel , Yeh Shan-Ju , Li Shilong , Liu Ke , Zhou Guoli , Xing Jing , VanVelsen Austin , VanVelsen Tyler , Paithankar Shreya , Feng Benjamin Y. , Young Krista , Strug Michael , Turco Lauren , Wang Zichen , Schadt Eric , Chen Rong , Li Xiaohong , Oskotsky Tomiko , Sirota Marina , Glicksberg Benjamin S. , Nadkarni Girish N. , Moeser Adam J. , Li Li , Kim Seungtaek , Zhou Jiayu , Chen Bin
Published: December 2020

Epidemiological studies suggest that men exhibit a higher mortality rate to COVID-19 than women, yet the underlying biology is largely unknown. Here, we seek to delineate sex differences in the gene expression of viral entry proteins ACE2 and TMPRSS2, and host transcriptional responses to SARS-CoV-2 through large-scale analysis of genomic and clinical data. We first compiled 220,000 human gene expression profiles from three databases and completed the meta-information through machine learning and manual annotation. Large scale analysis of these profiles indicated that male samples show higher expression levels of ACE2 and TMPRSS2 than female samples, especially in the older group (>60 years) and in the kidney. Subsequent analysis of 6,031 COVID-19 patients at Mount Sinai Health System revealed that men have significantly higher creatinine levels, an indicator of impaired kidney function. Further analysis of 782 COVID-19 patient gene expression profiles taken from upper airway and blood suggested men and women present distinct expression changes. Computational deconvolution analysis of these profiles revealed male COVID-19 patients have enriched kidney-specific mesangial cells in blood compared to healthy patients. Together, this study suggests biological differences in the kidney between sexes may contribute to sex disparity in COVID-19.
Cerebral Hemodynamics and Intracranial Compliance Impairment in Critically Ill Covid-19 Patients: A Pilot Study
Authors: Brasil Sérgio , Taccone Fabio , Wayhs Sâmia , Tomazini Bruno , Annoni Filippo , Fonseca Sérgio , Bassi Estevão , Lucena Bruno , Nogueira Ricardo , de-Lima-Oliveira Marcelo , Bor-Seng-Shu Edson , Paiva Wellingson , Turgeon Alexis , Teixeira Manoel , Malbouisson Luiz Marcelo
Published: December 2020

Introduction: One of the possible mechanisms by which the new coronavirus (SARS-Cov2) could induce brain damage is the impairment of cerebrovascular hemodynamics (CVH) and intracranial compliance (ICC) due to the elevation of intracranial pressure (ICP). The main objective of this study was to assess the presence of CVH and ICC alterations in patients with COVID-19 and evaluate their association with short-term clinical outcome.Methods: 50 consecutive critically ill COVID-19 patients were studied with transcranial Doppler (TCD) and a non-invasive monitoring of ICC. Subjects were included upon ICU admission; CVH was evaluated using mean flow velocities in the middle cerebral arteries (mCBFV), pulsatility index (PI) and estimated cerebral perfusion pressure (eCPP) while ICC was assessed by using the P2/P1 ratio of estimated ICP curve (B4C device). The primary composite outcome was unsuccessful weaning from respiratory support or death on day 7.Results: At the first assessment (n= 50) only P2/P1 (1.20 [1.00-1.28] vs. 1.00 [0.88-1.16]; p=0.03) and eICP (14 [11-25] vs. 11 [7-15] mmHg; p=0.01) were significantly higher among patients with unfavorable outcome (UO) than others. Patients with UO had a significantly higher CVH/ICC score (9 [8-12] vs. 6 [5-7]; p<0.001) than those with favorable outcome; the area under the receiver operating curve (AUROC) for CVH/ICC score to predict UO was 0.86 (95% CIs 0.75-0.97); a score > 8.5 had 63 (46-77)% sensitivity and 87 (62-97)% specificity to predict UO. For those patients undergoing a second assessment (n=29) after a median of 11 (5-31) days, all measured variables were similar between the two time-points. No differences in the measured variables between ICU non-survivors (n=30) and survivors were observed.Conclusions: ICCI and CVH disturbances are often present in COVID-19 severe illness and could accurately predict early poor outcome.
The Nomogram Application to Predict the Overall and Disease-specific Survival in Synovial Sarcoma: A Population Study
Authors: Xiao Bo , Chen Zhuoyuan , Liu Liyan , Li Aoyu , Wang Pingxiao , Xiang Cheng , Li Hui , Xiao Tao
Published: December 2020

Background: Synovial sarcoma is an uncommon soft sarcoma that lacks prognostic prediction models. The nomograms were employed to predict patients’ survival of synovial sarcoma. Methods: Materials collected from 1941 synovial sarcoma cases in the SEER database were analyzed. We employed univariate and multivariate cox analyses to identify the independent prognostic variables. Based on these outcomes, the nomograms were built for predicting 1-, 3-, and 5- year overall survival rate and disease-specific survival rate and then validated in external dataset. C-indices, calibration plots and ROC curves were applied to assess nomogram accuracy. Results: Patients were randomly classified into the training (n=1361) and testing (n=580) cohorts. Age, race, sex, primary anatomic site, chemotherapy, subtypes, surgery, SEER historic stage and tumor size were identified as independent prognostic variables (P<0.05) and then the nomogram of overall survival was constructed. Similarly, the nomogram of disease-specific survival was constructed. C-indices of training cohort for predicting overall and disease-specific survival were 0.779 and 0.779, respectively. Corresponding values of testing cohort were 0.769 and 0.765, respectively. The AUC values of prognostic model in the training cohort at 1-, 3-, 5- years of overall survival were 0.845, 0.785, and 0.788, respectively. Corresponding of disease-specific survival were 0.835, 0.783, and 0.787, respectively. The calibration plots illustrated excellent consistency between the survival rate of predicted and actual survival. Conclusion: we constructed the reliable nomograms for synovial sarcoma patients to predict overall and disease-specific survival, which can offer precise and personalized survival prediction.
SARS-CoV-2-induced impaired immune response by Prostaglandin E2 is accelerated by age, male sex and air pollution
Authors: Ricke-Hoch Melanie , Stelling Elisabeth , Lasswitz Lisa , Gunesch Antonia-Patricia , Kasten Martina , Zapatero-Belinchón Francisco J. , Brogden Graham , Gerold Gisa , Battmer Karin , Pietschmann Thomas , Montiel Virginie , Balligand Jean-Luc , Facciotti Federica , Hirsch Emilio , Elbahesh Husni , Rimmelzwaan Guus , Hoefer Anne , Kühnel Mark , Jonigk Danny , Eigendorf Julian , Tegtbur Uwe , Mink Lena , Scherr Michaela , Illig Thomas , Schambach Axel , Pfeffer Tobias , Andrée Birgit , Hilfiker Andres , Haverich Axel , Hilfiker-Kleiner Denise
Published: December 2020

The SARS-CoV-2 coronavirus has led to a pandemic with millions of people affected. The present study finds prostaglandin E2 (PGE2) blood levels elevated in COVID-19 patients with positive correlation with disease severity. SARS-CoV-2 induces PGE2 generation and secretion in infected lung epithelial cells by upregulating cyclo-oxygenase (COX)-2 and reducing the PG-degrading enzyme 15-hydroxyprostaglandin-dehydrogenase. Also living human-lung-precision-slices infected with SARS-CoV-2 display upregulated COX-2. PGE2 in serum of COVID-19 patients lowers the expression of Paired-Box-Protein-Pax-5 (PAX5), a master regulator of B-cell survival, proliferation and differentiation, in both human and mouse pre-B-cells, while the PGE2 inhibitor taxifolin directly reduces SARS-CoV-2-induced PGE2 production and attenuates viral replication. Risk-factors for severe disease courses, i.e. older age, male sex and air pollution are associated with higher PGE2 production and lower PAX5 expression in pre-B-cells. Since PGE2 acts broadly immunosuppressive its elevation might reduce the early anti-viral defense and its inhibition may therefore reduce severe disease courses.