bluuebunny/crossref_metadata_2025 huggingface dataset:
Alternative method for approaches to intracranial metastases in budget Constrained settings
Authors: Fonseca Ana Monize Ribeiro , Viana Fabiana Ramos , Teixeira Larissa de Araújo Correia , Guerra Mellyne Henriques , Moura Maria Alice Menezes , Santos Bruno Fernandes de Oliveira
Published: January 2022

Introduction: Preference has been given to minimally invasive approaches to the intracranial metastases, and alternative methods should be developed especially for environments with budget constraints. Objectives: This paper aims to describe a technique using a application for smartphone and a pair of compasses in approaches to intracranial metastases in a budget-constrained environment. Methods: Two cases are reported describing a technique of microsurgical treatment of brain metastases in a minimally invasive approach using a smartphone application that allows the planning of approaches to intracranial metastases. The NeuroKeypoint app is available in the App Store and Google Play Store. The compass Trident 9001 was used in association. Results: The incisions for craniotomies were marked at the indicated points according to the Neurokeypoint application. A single point marking was prioritized, corresponding to the center of the intended craniotomy. Intraoperative ultrasound was done before corticectomy and the location of the lesion was confirmed. The lesions were easily localized in both cases and both craniotomies were considered as adequate. Conclusion: The NeuroKeypoint application provides a low-cost and widely available alternative, making it accessible to a wide range of services.
Recurrence of supratentorial ependymoma in a brazilian child
Authors: Catão Juliana Rossi , Debastiani Mariana Severo , Everling Matheus Dalla Barba , Ko Tereza , Herwig Gabriela Klein , Mantovani Giovana Berti , Fossá Matheus Henrique Rossoni , Aires Leonardo Kleinschmitt , Fin Manuella Giusti , Lobato Lara Willers , Albuquerque Roberta Beiser de Medeiros e , Rossato Artur Vestena , Bedin André , Bizzi Jorge Wladimir Junqueira
Published: January 2022

Ependymomas are tumors resulting from neoplasms in ependymal cells. They represent the third most common tumor of the central nervous system in pediatric patients, occurring more frequently intracranially, in addition to having a high rate of local recurrence. Three-dimensional reconstruction is an emerging technology that promises benefits to professionals, patients, and students. We report the case of a 3-year-old female patient with a recurrent left frontal ependymoma, as well as its unique 3D reconstruction. The primary lesion was clinically manifested by gait imbalance, and recurrence was identified by resonance magnetic imaging. This type of tumor requires resection surgery as main treatment, and total removal is associated with lower mortality and low recurrence rate. Despite that, in the present study, the primary lesion was partially resected, which represents a tendency to recurrence. The case was presented through a 3D reconstruction of the recurred intracranial lesion and the postoperative period, based on image exams of the patient, to discuss the surgical approach. In addition, the 3D model is an innovation that allows preoperative practice by neurosurgeons and improves the clinical understanding of the patient and their family by enabling the observation of structures. Also, it aids in medical education by ensuring 3D visualization, essential for the study of anatomy. Therefore, the present work adds to the scientific literature new possibilities offered by 3D reconstruction technology.
Delirium como manifestação da hemorragia subaracnoidea. Revisão da literatura
Authors: Crestani Leticia Novak , Kalkmann Gabriela Ferreira , Rabelo Nicollas Nunes , Pereira Carlos Umberto
Published: January 2022

Objetivo: Revisão de literatura sobre delirium em paciente com hemorragia subaracnoidea (HSA), tema de grande importância para o médico neurocirurgião e neurointensivista, dado que é uma condição que necessita de identificação e diagnóstico precoce, bem como manejo adequado para não acarretar em pior prognóstico. Material e método: Trata-se de um artigo de revisão da literatura utilizando as bases PubMed, Scielo e Cochrane, utilizando os termos: “Delirium”, “Agitation” e “Subarachnoid Hemorrhage”. Foram selecionados artigos entre 2005 a 2019, resultando em um total de onze artigos que preencheram os critérios de inclusão: citações, respectivos impactos e conteúdo. Resultado: O delirium pode ser uma forma de apresentação da hemorragia subaracnoidea, podendo levar a maior tempo de internação hospitalar, maiores complicações e pior prognóstico. Por vezes, esse transtorno neurocognitivo não é identificado nos pacientes com HSA e é frequentemente confundido com outros transtornos como ansiedade, depressão e demência. Seu diagnóstico precoce acarreta melhor qualidade de vida ao paciente e pode ser feito por diversos algoritmos como CAM, Nu-DESC e RASS, sendo este último o mais efetivo em pacientes com hemorragia subaracnoidea. Conclusão: O manejo adequado deve ser realizado com base na identificação da causa, com tratamento sintomático e controle ambiental. Tendo em vista ser uma condição que necessita ser identificada precocemente para melhor prognóstico, é de suma importância que médicos neurocirurgiões e neurointensivistas saibam diagnosticá-la em pacientes com hemorragia subaracnoidea.
Aneurismas gigantes da artéria cerebral média. Revisão de literatura
Authors: Vignoli Nathalia Akemi , Furlan Marcos Roberto , Damin Carr De Muzio Samuel
Published: January 2022

Aneurismas cerebrais gigantes de artéria cerebral média (ACM) possuem características particulares relacionadas não só à morfologia, predominantemente sacular, como também à topografia. Apesar de constituir uma porcentagem pequena em relação aos aneurismas intracranianos, há alta taxa de ruptura relacionada com alta mortalidade (maior que 60% em dois anos). As abordagens do tratamento são baseadas primariamente na microcirurgia por clip reconstruction. No entanto, a técnica endovascular e a revascularização por bypass podem ser associadas. Dessa forma, o tratamento visa alcançar melhores desfechos clínicos e melhores taxas de sobrevida. Como contribuição ao tema, essa revisão de literatura feita em bases de dados, considerando o intervalo entre 1997 e 2017 e teve como objetivo apresentar e discutir os principais tratamentos desses aneurismas e analisar as propriedades que o levaram a ser tão importante para a neurocirurgia vascular. Como conclusão, verifica-se que é imprescindível o estabelecimento da abordagem multidisciplinar no tratamento de aneurismas gigantes de ACM, além de mais estudos, com intuito de criar novas perspectivas.
Plasmocitoma solitário ósseo em região cranioencefálica occipital. Revisão e relato
Authors: Mariano Patrick Moro , Russo Larissa Fernanda Fonseca , Sodré André Rodrigues , Fernandes Alfredo das Neves Magalhães , Ortega Manoela Marques , Oliveira Carlos Tadeu Parisi de
Published: January 2022

Introdução: Plasmocitomas solitários (PS) são tumores sólidos, originados da proliferação local de linfócitos B maduros, que adquirem um padrão de multiplicação monoclonal e desordenado, correspondendo a 5% de todos os tumores de células plasmáticas. Quando não há evidência de discrasia plasmocitária em outros locais do corpo, o crânio e o sistema nervoso central são raramente afetados de maneira isolada por esse tipo de tumor, dificultando a realização de seu diagnóstico, sendo apenas definitivo através de exames imuno-histoquímicos e histopatológicos. Objetivo: O presente relato teve como objetivo reportar um caso raro de PS ósseo (PSO) em região cranioencefálica occipital, de importante significância clínica frente à escassez de relatos semelhantes existentes na literatura nacional e mundial. Resultados: Paciente de 78 anos encaminhado ao Hospital devido a abaulamento de crescimento progressivo em região occipital, mas consciente, orientado e sem déficits neurológicos focais. A tomografia computadorizada (TC) e angio-TC de crânio evidenciaram lesão expansiva sólida extra-axial com destruição óssea da calvária occipitoparietal. Foi realizada ressecção subtotal da lesão, tendo sido observada marcação para CD138, antígeno de plasmócitos MI15 (+), cadeia leve de imunoglobulina Kappa 18B5 (+), Lambda (-) e S-100 (-), confirmando o diagnóstico de PSO em região cranioencefálica occipital. O paciente obteve recuperação completa e, após um ano, evoluiu a óbito devido a complicações cardiovasculares. Conclusões: PSO é uma discrasia de células plasmáticas rara, mais comum em homens acima de 40 anos. A excisão cirúrgica do tumor faz parte de uma excelente medida primária. Portanto, conhecer aspectos clínicos garante o sucesso diagnóstico, visto a real probabilidade de evolução para mieloma múltiplo ou metástases.
Las producciones Calderón y la continuidad del cine industrial mexicano (1960-1980)
Authors: Flores Silvana
Published: January 2022

Este trabajo analizará las problemáticas que el cine mexicano enfrentó tras el fin de su auge industrial en Hispanoamérica desde los años sesenta, partiendo de un estudio de caso: las estrategias de una familia de productores, los hermanos Calderón, destacados por elaborar películas de corte popular. Este artículo procura dilucidar las formas en que la cinematografía industrial en México buscó su continuidad en los mercados y la captación de públicos en tiempos de modernización y transformación de paradigmassociales, y determinar las alternativas narrativas y estéticas promovidas por estos productores en sus films de los años sesenta a ochenta para lograr su permanencia en la industria en medio de la crisis. Para ello, se establecerá un panorama general sobre el estado del cine mexicano en aquel punto de inflexión, que contextualizará el estudio de caso, metodología a través de la cual se enumerarán las propuestas estéticasy narrativas planteadas por los Calderón, estableciendo una confluencia entre el contexto de crisis de la cinematografía mexicana, la tendencia de innovación estética y reflexividad de los llamados nuevos cines latinoamericanos que emergieron simultáneamente, y las propuestas de los Calderón en pos de la captación de públicos por medio de los géneros abordados durante estos años (el cine fantástico y de terror, el cine deluchadores y los films de ficheras). Los resultados obtenidos corroboran la existencia de una confrontación de tendencias en el cine mexicano del período que opone aquel cine industrialista con la alta cultura.
El lenguaje político en Twitter durante la segunda vuelta presidencial Colombia 2018
Authors: Gallego Galvis Sandra Ximena , Gayón Tavera Delsar Roberto , Alzate Pongutá Juan Felipe
Published: January 2022

La segunda vuelta electoral por la presidencia de Colombia, 28 de mayo al 16 de junio de 2018, se caracterizó por la ausencia de un debate entre los candidatos de la Colombia Humana y el Centro Democrático. La contienda electoral se centró en las redes sociales y los dos candidatos usaron, a través de la red social Twitter, estrategias del lenguaje de oposición, resistencia, encubrimiento, legitimación y deslegitimación que agudizaron la polarización entre el llamado al nacionalismo, la salvaguarda de las instituciones y un nuevo proyecto de país. El presente artículo tiene como objetivo evidenciar estas estrategias utilizadas por los aspirantes a la presidencia, durante la segunda vuelta electoral que circularon en Twitter con la finalidad de captar potenciales electores. La investigación utiliza una metodología mixta compuesta de dos enfoques. El análisis descriptivo de corte cuantitativo para recuperar los 391 trinos emitidos desde las cuentas deTwitter de la Colombia Humana y el Centro Democrático durante las tres semanas de campaña. Posteriormente se efectuó un análisis crítico del discurso político para establecer la articulaciónde las relaciones entre política, redes sociales y lenguaje. Los hallazgos indican una continuidad en las prácticas políticas en relación con los dos anteriores periodos electorales caracterizados por el enfrentamiento y la hostilidad entre dos bloques ideológicamente opuestos: derecha y la izquierda.
Facebook, medio de comunicación de las organizaciones campesinas del Catatumbo
Authors: Barbosa Trigos Jairo Fernando , Ríos Pacheco Elvis Fernando
Published: January 2022

El artículo responde a la investigación titulada Evolución e impacto de la red social Facebook como medio de comunicación masiva de las organizaciones campesinas del Catatumbo, Ascamcat y Cisca, desarrollada para identificar las dinámicas existentes en el uso del medio social como una herramienta de difusión de las actividades propias de las organizaciones citadas, teniendo en cuenta la importancia de sus acciones mediáticas en la subregión del departamento Norte de Santander, el Catatumbo colombiano, de allí la relevancia para los habitantes del lugar, quienes pueden aprovechar la herramienta en su progreso social.

La investigación recolectó datos cualitativos por medio de observación y entrevistas semiestructuradas, dando lugar a la comprensión que la Web 2.0 trajo, y así determinar las dinámicas producto del uso de Facebook como medio de comunicación por parte de las organizaciones campesinas del Catatumbo,  scamcat y Cisca.

Para la Asociación Campesina del Catatumbo y el Comité de integración Social del Catatumbo, Facebook es una herramienta que apoya tres ejes: visibiliza las actividades desarrolladas por cada organización; muestra las realidades propias de la región integrada por once municipios en el departamento Norte de Santander; y desmiente o contrarresta informaciones emitidas por los medios de comunicación masiva del orden departamental y nacional.

Por consiguiente, aunque la red social virtual no fue creada ni diseñada para ser un medio de comunicaciónmasiva, en esencia se convierte en la ventana que permite mostrar las realidades del Catatumbo, desmintiendo en algunos casos el discurso hegemónico de los tradicionales medios, radio, prensa y televisión.
Pengaruh komitmen pegawai dan lingkungan kerja fisik terhadap kinerja pegawai di Dinas Perindustrian Dan Perdagangan Kota Jambi
Authors: Akbariko Akbariko , Edward Edward , Chairunnisa Fitri
Published: January 2022

Employees or human resources (HR) are vital assets in almost all types of organizations which are the main pillars and the driving force of the organization to realize its vision and mission. The research was conducted at the Department of Industry and Trade of Jambi City. Data were collected through questionnaires distributed to 65 people using a Liker scale. The research was conducted using a data analysis tool, namely SPSS version 23. The data testing technique used in this study included validity testing with factor analysis, reliability testing with Cronbach's Alpha. T-test and multiple linear regression analysis tests and prove the research hypothesis. The analysis results show that organizational commitment and work environment have a significant positive effect on employee performance.
Pengaruh inovasi produk terhadap keputusan pembelian kaos Merek JAKOZ
Authors: Fansuri Faisal , Octavia Ade , Kartika Sylvia
Published: January 2022

This study aims to determine the effect of a variable products innovation consisting of sub-variables relative advantage, compatibility, complexity, divisibility, and communicability on purchasing decisions on a T-shirt & Souvenir Jakoz outlets in the city of Jambi. This research is a survey using a questionnaire instrument. The samples used were 100 consumer brands Jakoz shirts. The analytical tool used is multiple linear regression analysis. This study indicates that product innovation (relative advantage, compatibility, complexity, divisibility, and communicability) simultaneously influences consumer purchasing decisions in partial compatibility, complexity, divisibility, and communicability influence purchase decisions. In contrast, the relative superiority does not affect the purchase decisions on Jakoz shirt brand products in Jambi.
Leaf trichomes reduce boundary layer conductance
Authors: Buckley Thomas , Pierce Marshall A. , Sack Lawren
Published: January 2022

Leaf trichomes (hairs) have multiple hypothesized functions, of which
several require empirical evidence. An important, yet controversial,
proposed function of trichomes is to influence the leaf boundary layer,
which would affect leaf temperature, transpiration and photosynthesis,
and may confer differential benefits depending on climate. We used
dynamic infrared thermography to test whether trichomes reduce the
boundary layer conductance to heat ( g),
impeding heat transfer between leaves and air. For five species, with
trichome lengths of 135-780 μm, we transiently heated leaves with a
radiative light source, measured the time constant for subsequent leaf
cooling simultaneously in two adjacent leaf regions (with and without
trichomes) with an IR camera, and inferred g
using an energy balance model. Cooling was slower in hairy leaf regions
relative to bald regions, corresponding to a lower g in hairy regions, by 2.4% to 39% across species.
Contrary to prior theory, the resistance added by trichomes was
unrelated to the depth of the hair layer (i.e., trichome height) across
species. Simulations predicted that the reduction in g by trichomes would influence energy balance and gas
exchange rates by up to a few percent, with the direction and magnitude
of such effects depending sensitively on environmental conditions.
Put your weight behind it – effect of BMI on the active second stage of labour: A retrospective cohort study.
Authors: Østborg Tilde , Sande Ragnar , Kessler Joerg , Tappert Christian , Brandis Philip , Eggebo TM
Published: January 2022

Objective: To explore the duration of the active phase of the second
stage of labour in relation to maternal prepregnant body mass index
(BMI). Design: Retrospective cohort study. Setting: Labour wards of
three Norwegian university hospitals, 2012-2019. Population: Nulliparous
and parous women without previous caesarean section with a live
singleton foetus in cephalic presentation and spontaneous onset of
labour, corresponding to the Ten Group Classification System (TGCS)
group 1 and 3. Methods: Women were stratified to BMI groups according to
WHO classification, and estimated median duration of the active phase of
the second stage of labour was calculated using Kaplan-Meier analyses.
We performed stratified analyses in women with and without epidural
analgesia and oxytocin augmentation. Finally, we calculated the Hazard
Ratio (HR) of delivery using Cox regression analyses. Caesarean sections
and operative vaginal deliveries during the active phase were censored.
Main Outcome Measures: Estimated median duration of the active phase of
second stage of labour. Results: The final study population comprised
23516 women in TGCS group 1 and 27255 in group 3. Increasing BMI was
associated with shorter estimated median duration of the active phase in
both TGCS groups. The pattern remained when performing stratified
analyses for epidural and oxytocin analgesia. The HR for delivery
increased significantly with increasing BMI analysed as a continuous
variable; HR 1,019 (95%CI 1.016-1.023) in TGCS group 1 and HR 1,017
(95%CI 1.014-1.020) in TGCS group 3. Conclusion: Increasing BMI was
associated with shorter estimated median duration of the active second
stage Funding: None.
Giant vegetation of the tricuspid valve in a healthy patient without risk factors for right-sided endocarditis
Authors: Durieux rodolphe , Henrard Valérie , Granato Renzo , Knapen Mérédith , Amabili Philippe , Defraigne Jean Olivier
Published: January 2022

We present the case of a middle-aged man who developed an infective
endocarditis of the tricuspid valve caused by methicillin-sensitive
Staphylococcus aureus and associated with a very large vegetation
(nearly 5 cm). Besides the quite unusual size of the vegetation, this
report highlights that severe right-sided endocarditis can occur in the
absence of classical risk factors (intravenous drug abuse, presence of a
cardiac implantable electronic device or other intravascular device, and
underlying right-sided cardiac anomaly) and that some cases of severe
tricuspid endocarditis can be successfully treated by partial excision
and patch repair.
Metabarcoding data reveal vertical multi-taxa variation in topsoil communities during the colonization of deglaciated forelands
Authors: Guerrieri Alessia , Carteron Alexis , Bonin Aurélie , Marta Silvio , Ambrosini Roberto , Caccianiga Marco , Cantera Isabel , Compostella Chiara , Diolaiuti Guglielmina , Fontaneto Diego , Gielly Ludovic , Gili Fabrizio , Gobbi Mauro , Poulenard Jérôme , Taberlet Pierre , Zerboni Andrea , Thuiller Wilfried , Ficetola Gentile Francesco
Published: January 2022

Ice-free areas are increasing worldwide due to the dramatic glacier
shrinkage and are undergoing rapid colonization by multiple lifeforms,
thus representing key environments to study ecosystem development. Soils
have a complex vertical structure. However, we know little about how
microbial and animal communities differ across soil depths and
development stages during the colonization of deglaciated terrains, how
these differences evolve through time, and whether patterns are
consistent among different taxonomic groups. Here, we used environmental
DNA metabarcoding to describe how community diversity and composition of
six groups (Eukaryota, Bacteria, Mycota, Collembola, Insecta,
Oligochaeta) differ between surface (0-5 cm) and relatively deep (7.5-20
cm) soils at different stages of development across five Alpine
glaciers. Taxonomic diversity increased with time since glacier retreat
and with soil evolution; the pattern was consistent across different
groups and soil depths. For Eukaryota, and particularly Mycota,
alpha-diversity was generally the highest in soils close to the surface.
Time since glacier retreat was a more important driver of community
composition compared to soil depth; for nearly all the taxa, differences
in community composition between surface and deep soils decreased with
time since glacier retreat, suggesting that the development of soil
and/or of vegetation tends to homogenize the first 20 cm of soil through
time. Within both Bacteria and Mycota, several molecular operational
taxonomic units were significant indicators of specific depths and/or
soil development stages, confirming the strong functional variation of
microbial communities through time and depth. The complexity of
community patterns highlights the importance of integrating information
from multiple taxonomic groups to unravel community variation in
response to ongoing global changes.
The Three Seasons - Prague Spring, World Youth Summer, and ‘Sofia Autumn,’ or: The anti-event, the avant-garde, and the beginning of Bulgaria’s new folklore wave
Authors: Becker-Naydenov Patrick
Published: January 2022

This article deals with the events of 1968 in Bulgarian musical culture.
Departing from recent Bulgarian discourses that have emerged in the new
millennium and often regard Bulgarian responses to the Prague Spring as
nearly non-existing, a closer look at music and the arts reveals a more
detailed picture. Here, ?1968? is especially interesting since it saw the
beginning of a Bulgarian New Folklore Wave that challenged existing
compositional models for adapting folk music. Furthermore, right before the
military intervention in Czechoslovakia in August, the Bulgarian capital
Sofia became a center of international attention for hosting the 9th World
Festival of Youth and Students. Finally, a look at a series of infamous
party meetings held at the Union of Bulgarian Composers in November 1968
reveals that unknown protagonists managed to destroy paper evidence that
could have shed a better light at the events of this year.
Risk of Developing Type 2 Diabetes in Individuals With a Psychiatric Disorder: A Nationwide Register-Based Cohort Study
Authors: Lindekilde Nanna , Scheuer Stine H. , Diaz Lars J. , Rubin Katrine H. , Plana-Ripoll Oleguer , Henriksen Jan Erik , Lasgaard Mathias , Andersen Gregers S. , Pouwer Frans
Published: January 2022

OBJECTIVE
Previous studies have investigated the incidence of
type 2 diabetes in individuals with psychiatric disorders, but most studies
have focused on a specific psychiatric disorder or a selected sample. More
population-based studies are needed to determine these associations in
representative samples. We therefore aimed to determine these associations in a
nationwide, register-based dynamic cohort study.

RESEARCH DESIGN AND
METHODS We analyzed
data from 5,005,612 adults living in Denmark between 1995 and 2018, without
prior diabetes. We investigated 10 different categories of psychiatric
disorders, and a composite group with any psychiatric disorder. Individuals
with a psychiatric disorder were compared to individuals without, using
multivariable-adjusted Poisson regression to estimate incidence rate ratios
(IRR) of type 2 diabetes. We modeled age-specific incidence rates (IR) for
individuals with and without the specific psychiatric disorder. All models were
stratified by sex.

RESULTS
In total, 334,739
individuals developed type 2 diabetes during follow-up. For all investigated
categories of psychiatric disorders, we found increased IR of type 2 diabetes for
individuals with versus those without a psychiatric disorder (IRR: men: 1.47 (95% CI:1.45-1.50), women: 1.65 (95% CI: 1.62-1.68)). When we examined age-specific IR, the largest differences were found in
the younger population (<50 years).

CONCLUSIONS
We found that the IR of type 2 diabetes
was higher in individuals with a psychiatric disorder compared to individuals
without a psychiatric disorder and particularly high in the younger people with
a psychiatric disorder. New studies into the prevention and early detection of
type 2 diabetes in these groups are warranted.
Clinical predictors and long-term impact of acute kidney injury on progression of diabetic kidney disease in Chinese patients with Type 2 diabetes
Authors: Jiang Guozhi , Luk Andrea O. , Tam Claudia H.T. , Ozaki Risa , Lim Cadmon K.P. , Chow Elaine Y.K. , Lau Eric S. , Kong Alice P.S. , Fan Baoqi , Group Hong Kong Diabetes Register TRS Study , Lee Ka Fai , Siu Shing Chung , Hui Grace , Tsang Chiu Chi , Lau Kam Piu , Leung Jenny Y. , Tsang Man-wo , Kam Grace , Lau Ip Tim , Li June K. , Yeung Vincent T. , Lau Emmy , Lo Stanley , Fung Samuel , Cheng Yuk Lun , Chow Chun Chung , Group Hong Kong Diabetes Biobank Study , Tang Nelson LS , Huang Yu , Lan Hui-yao , Oram Richard A , Szeto Cheuk Chun , So Wing Yee , Chan Juliana C.N. , Ma Ronald C.W.
Published: January 2022

We aim to assess the long-term impact of AKI on progression of diabetic
kidney disease and all-cause mortality, and
investigate determinants of AKI in Chinese patients with type 2 diabetes (T2D).
A consecutive cohort of 9,096 Chinese patients with T2D from the Hong Kong Diabetes
Register were followed for 12 years (mean[SD] age 57±13.2 years; 46.9% men;
duration of diabetes 5 years). AKI was defined based on the KDIGO criteria using serum creatinine. Estimated
glomerular filtration rate measurements were
used to identify the first episode with chronic kidney disease (CKD) and
end-stage renal disease (ESRD). Polygenic risk score (PRS) composed of 27 SNPs
known to be associated with serum uric acid (SUA) in European populations was used to examine the role of SUA
in pathogenesis of AKI, CKD and ESRD. Validation was sought in an independent
cohort including 6,007 patients (mean age 61.2±10.9 years; 59.5% men; median duration of diabetes
10 years). Patients with AKI had a higher risk for developing incident
CKD (HR [95% CI]: 14.3[12.69-16.11]), ESRD (12.1[10.74-13.62]) and all-cause death (7.99[7.31-8.74]), compared with those without AKI. Incidence rate for ESRD
among patients with 0, 1, 2, ³ 3
episodes of AKI were 7.1, 24.4, 32.4, 37.3 per 1000 person-years. Baseline SUA
was a strong independent predictor for AKI. A PRS composed of 27 SUA-related SNPs
was associated with AKI and CKD in both discovery and replication cohorts, but
not ESRD. Elevated SUA may increase the risk of diabetic kidney disease through
increasing AKI. The identification of SUA as a modifiable risk factor and PRS as
a non-modifiable risk factor may facilitate the identification of high-risk
individuals to prevent AKI and its long-term impact in T2D.
Incidence of Type 1 Diabetes in Children and Adolescents During the COVID-19 Pandemic in Germany: Results From the DPV Registry
Authors: Kamrath Clemens , Rosenbauer Joachim , Eckert Alexander J. , Siedler Kai , Bartelt Heike , Klose Daniela , Sindichakis Marina , Herrlinger Silke , Lahn Valentina , Holl Reinhard W
Published: January 2022

Objective: The aim of this study was to investigate the incidence of
type 1 diabetes in children and adolescents during the Covid-19 pandemic
in Germany compared to previous years.

Research Design and Methods: Based on data from the multicenter
German Diabetes Prospective Follow-up Registry (DPV), we analyzed the
incidence of type 1 diabetes per 100,000 patient years in children and
adolescents from January 1, 2020, through June 30, 2021. Using Poisson
regression models, expected incidences for 2020/21 were estimated based
on the data from 2011 to 2019, and compared to observed incidences in
2020/21 by estimating incidence rate ratios (IRRs) with its 95%
confidence interval (CI).

Results: From January 1, 2020, to June 30, 2021, 5,162 children and
adolescents with new-onset type 1 diabetes in Germany were registered.
The observed incidence in 2020/21 was significantly higher than the
expected incidence (24.4 [95% CI, 23.6–25.2] vs. 21.2 [20.5–21.9]; IRR,
1.15 [1.10–1.20], p<0.001). IRRs were significantly elevated in June
2020 (IRR, 1.43 [1.07–1.90], p=0.003), July 2020 (IRR, 1.48 [1.12–1.96],
p<0.001), March 2021 (IRR, 1.29 [95% CI, 1.01–1.65], p=0.028), and
June 2021 (IRR, 1.39 [1.04–1.85], p=0.010).

Conclusions: A significant increase in the incidence of type 1
diabetes in children was observed during the Covid-19 pandemic, with a
delay in the peak incidence of type 1 diabetes by approximately three
months after the peak Covid-19 incidence and also after pandemic
containment measures. The underlying causes are yet unknown. However,
indirect effects of the pandemic are more likely to be the cause than
direct ones.
Glutamine Regulates Skeletal Muscle Immunometabolism in Type 2 Diabetes
Authors: Dollet Lucile , Kuefner Michael , Caria Elena , Rizo-Roca David , Pendergrast Logan , Abdelmoez Ahmed M. , Karlsson Håkan KR , Dalbram Emilie , Treebak Jonas , Harada Jun , Näslund Erik , Rydén Mikael , Zierath Juleen R. , Pillon Nicolas J. , Krook Anna
Published: January 2022

Dysregulation of skeletal muscle
metabolism influences whole body insulin sensitivity and glucose homeostasis. We hypothesized that type 2 diabetes-associated
alterations in the plasma metabolome directly contribute to skeletal muscle
immunometabolism and the subsequent development of insulin resistance. To this
end, we analyzed the plasma and skeletal muscle metabolite profile and identified
glutamine as a key amino acid that correlated inversely with body mass index
(BMI) and HOMA-IR index in men with normal glucose tolerance or type 2
diabetes. Using an in vitro model of human myotubes and an in vivo
model of diet-induced obesity and insulin resistance in male mice, we provide
evidence that glutamine levels directly influence the inflammatory response of
skeletal muscle and regulates the expression of the adaptor protein GRB10, an
inhibitor of insulin signaling. Moreover, we demonstrate that a systemic
increase of glutamine levels in a mouse model of obesity improves insulin
sensitivity and restores glucose homeostasis. We conclude that glutamine
supplementation may represent a potential therapeutic strategy to prevent or
delay the onset of insulin resistance in obesity by reducing inflammatory
markers and promoting skeletal muscle insulin sensitivity.
Laser microwelding of stainless steel and pure aluminum foil
Authors: Kumar Aniruddha , Neogy Suman , Keskar Nachiket , Biswas D. J.
Published: January 2022

Joining of materials, with a strong bearing on the manufacturing industry, has remained an active area of research for decades. The demand for the fabrication of a variety of miniature components has placed more emphasis, in particular, on the welding of thin materials. Welding of thin materials is a challenging task, and more so if they are foils of dissimilar materials, as even a tiny weld flaw invariably can lead to a rapid blemishing of the job. Aluminum with its good thermal and electrical properties, low specific weight, and low cost is often considered a preferred material in many applications. In this communication, the authors present the result of a feasibility study of laser-assisted welding of stainless steel (AISI 304) and pure aluminum foils. A repetitive single-mode nanosecond fiber laser was used to carry out the weld in the lap joint configuration. Welding between the foils was done in the weld brazing mode. Electron microscopy, microhardness measurements, and tensile testing were carried on the weld to evaluate its microstructural and mechanical properties. In the course of welding, stainless steel remained in solid state, while aluminum underwent localized melting over a narrow zone at the interface. The use of very short duration repetitive laser pulses with lower heat input restricted the bulk diffusion of elements across the interface and thereby the generation of the intermetallic compound/second phase with minimum Heat Affected Zone and almost no distortion. This study establishes a nanosecond laser-assisted welding technique as an option for microwelding between stainless steel and aluminum foil.
Laser welding of copper to aluminum with spiral trajectory and identification of excessive aluminum melting
Authors: Mathivanan Karthik , Plapper Peter
Published: January 2022

Laser welding of copper and aluminum is challenging due to the formation of complex intermetallic phases. Only a defined amount of Al and Cu can be melted because of the limited solubility of Al–Cu systems. Finding the optimum melting is critical for a strong joint. Optical emission during the welding process contains the metal vapor of Al metal that is being welded. This is a good indicator for monitoring the welding process. This research paper focuses on the optical emission of Al from the bottom sheet during welding of Cu (top) and Al (bottom) in overlapped configuration for a spiral trajectory. The emitted signal in the range of 395 nm (±3 nm) from the bottom sheet of aluminum is used to identify excessive Cu–Al welding. The tensile shear strength, microstructure, and welding signal in the time domain for optimum and excessive weld conditions are investigated. In this study, a technique using a photodiode is shown to identify the excessive melting of Al during the welding process in real time.
EXPERIMENTAL SYSTEM OF VOCATIONAL TRAINING OF PHYSICAL CULTURE TEACHERS FOR ORGANIZATION PUPILS’ INDIVIDUAL WORK
Authors: Alieksieiev Oleksandr
Published: January 2022

Article outlines methods of introduction of experimental system of vocational training of future physical culture teachers for organization of individual work with pupils. It has been underlined that introduction of the developed system provided for the reasonable selection, structuring and construction of the content of study material in selected disciplines taking into account a purposeful influence on the formation of each component of readiness of future physical culture teachers for organization of individual work with pupils. In the process of research and experimental work it was taking into account that under the selection and structuring of the content of academic disciplines should be understood: strict definition of structure elements that make up the discipline; applying the procedures of optimization for each of these structural elements; establishing and maintaining in optimal state connections and interrelations between elements of the structure of academic discipline in accordance to the integrative criteria for evaluating the effectiveness of its construction. Methodical peculiarities of introduction of the developed system have been outlined. Realization of experimental system of vocational training of future physical culture teachers for organization of individual work with pupils was carried out on the basis of a number of fundamental postulates – principles. Given the complexity and versatility of the process of vocational training of future physical culture teachers for organization of individual work with pupils, principles of research activities have been systematized into some complex. In particular, it was decided to structure the principles into three blocks, each of them regulates the experimental activity or specifies the logic of selection of the essence of certain elements of the author’s pedagogical system.
CULTURAL AND EDUCATIONAL PROJECTS OF ODESA NATIONAL SCIENTIFIC LIBRARY AS WAYS OF PROMOTION LITERATURE, BOOKS AND READING IN MODERN SOCIETY
Authors: Biriukova Iryna
Published: January 2022

Libraries play an important role in the system of public institutions that ensure the right of citizens to information, knowledge, education, use of cultural achievements and public access to information resources, popularization of books and reading as a way of learning about the world, education of educated and comprehensively developed individuals with critical, panoramic thinking. The introduction of systematic measures to promote books and reading in modern society remains an extremely important mechanism of cultural, professional and intellectual enrichment, and in general – the development of human capital, its sustainable economic and social progress, increasing the competitiveness of the state in global political, economic, cultural and information space. The work of libraries, which are constantly looking for innovative forms of their activity, is inextricably linked with the process of raising the level of education and culture. The aim of this work is to examine the innovative experience of cultural and educational projects of Odesa National Scientific Library, which made the library an important center for the promotion of literature, reading and books. Currently, there is no single study that would reveal the experience of unique cultural projects of Odesa National Scientific Library. Thus, the systematization and analysis of information about these innovative projects implemented by the library is incredibly relevant.
PLACE OF LATIN IN CONTEXT OF TRENDS IN MODERN INTERDISCIPLINARY STEM EDUCATION
Authors: Lefterova Olga
Published: January 2022

The article attempts to rethink the meaning of modern education in the context of combining two opposing trends, to determine the status of Latin in the context of trends regarding modern education, which covers different fields of knowledge and combines interdisciplinary approaches. The solution to this issue is seen in the creation of a highly professional philosophy of education, where one of the leading places will be occupied by a combination of humanities, natural sciences and exact sciences. A special role in this process is taken by to Latin as a fundamental discipline in the process of language training of future specialists in the field of modern technologies. The prestige of Latin as a subject is that Latin for many centuries has played a significant role in the education system, in particular in specialized one, because this language is provided with vocabulary to explain certain abstractions. The article concludes that it is necessary to motivate future specialists to study Latin, which not only forms the fundamentals of the terminological base, but is a means of raising the level of scientific culture of future mathematicians, physicists, and IT specialists. Studying Latin at the departments of exact disciplines will help students not only to have a deeper understanding of terminology in their native language, but also to master the language competence required in research work.
INTRODUCTION OF THE COEXISTENCE EXPERIENCE INTO AN INCLUSIVE LEARNING ENVIRONMENT: PHILOSOPHICAL-ANTHROPOLOGICAL AND SOCIO-CULTURAL ANALYSIS
Authors: Mrynska Natalia
Published: January 2022

The article aims to improve the interaction between society and persons with disabilities. The author has found the interrelation between a person with a disability and Paul Tillich’s “the courage to be”. The research attempts to convince the public of the need to involve persons with disabilities, as representatives who are aware of a disability, in inclusive education. As a result of the re-use of L. Wittgenstein’s method and “pedagogy of experience” by V. Bederkhanova and I. Shustova, a mutually beneficial synthesis between experience and practice in the dimension of coexistence has been established. The objective necessity of simultaneous use of performance and performativity in pedagogical practice has been analyzed and described. The definition of “bilateral” or “double” inclusion has been formulated. The use of “bilateral inclusion” will expand the social boundaries for persons with disabilities and provide the necessary experience in the pedagogical realm for both children with disabilities and healthy children. The analysis and conclusions prove the effectiveness of involving persons who have faced a disability in an inclusive environment.
«THE UNSIMPLE» BY Т. PROKHASKO: A QUASI-HISTORICAL NOVEL
Authors: Pecherskyh Lubov
Published: January 2022

A historical novel is a work that is based on a historical plot, built on the reproduction in the artistic form of a certain historical epoch, a certain period of the people's or the country's past. In view of this, in a historical novel, historical truth must be combined with artistic truth, historical facts with artistic fiction, real historical figures with fictional characters.The postmodern ideology of the multiplicity of meanings, the hesitation in determining the differences between the false and the true, justify today's increase in interest in history and the historical novel as a modern textual reflection of the past. The study considers the artistic interpretation of the genre of quasi-historical postmodern novel on the material of the text “The UnSimple” by T. Prokhasko. The genre features of the text are determined, in particular inscribing a variant of an event to a certain historical epoch, defining national features with the help of a pseudo-historical plot, creating a geographical utopia and avoiding linearity, rooting a person in a new geographical landscape as a strategy ofhistorical discourse reconstruction.
THE RELATIONSHIP BETWEEN PROCRASTINATION AND CREATIVE THINKING
Authors: Rumyantseva Katerina , Movchan Larysa
Published: January 2022

The article considers the issue of the relationship between the phenomenon of procrastination and creative thinking. One of the most common factors that hinder personal and professional effectiveness is procrastination. There is a hypothesis that people with high levels of procrastination have correspondingly well-developed creative thinking, which endows them with the ability to solve problems outside the box and quickly adapt to situations.1 We consider procrastination as a psychological pattern of behavior characterized by person's delaying planned actions or decision-making followed by negative emotional experiences. Literature analysis has shown that procrastination influences creative activity, which leads to the assumption that people with higher levels of procrastination have a higher level of creativity. Upon conducting our research, we uncovered the following pattern: students with a high level of procrastination are more inclined to such factors as risk-taking and fantasy; students with a low level are more likely to present curiosity and task complexity; and students with an average level of procrastination are equally likely to present both factors.
THE ESTABLISHMENT OF A BALANCE BETWEEN PRIVATE INTERESTS OF THE AUTHORS AND PUBLIC INTERESTS OF THE SOCIETY IN THE DIGITAL AGE
Authors: Yefimenko Anastasiia
Published: January 2022

The aim of this paper is to analyse the DSM Directive through the perspective of insurance the balance between private and public interests. The paper analyses how technological growth has led to the adoption of the DSM Directive, the goals set by the legislator and if they were met in the DSM Directive. The paper as well reviews key points of the DSM Directive and how it influences the interests of different parties in copyright. The article focuses on press publishers’ rights, new exceptions and limitations and use of protected content by online content-sharing service providers, that were introduced by DSM Directive. The gaps of the DSM Directive are also reviewed in this article and how they impact the disbalance of interests in copyright. The article as well provides brief analysis how instruments brought up in DSM Directive may influence the copyright outside the EU. Methods used in this research: general scientific (analysis, induction, deduction), legal methods (legal comparation, formal legal method).
MOLECULAR MECHANISMS UNDERLYING CANCER CELL RADIORESISTANCE
Authors: Chorna Inna
Published: January 2022

Radioresistance of the tumor cells remains a significant obstacle for the radiotherapy treatment of cancer. Radioresistance involves multiple genes, factors, and mechanisms that adapt cancer cells or tissues to radiotherapy-induced changes and develop resistance to ionizing radiation. The major studies of the effect of radiation on cells reported include the following areas: 1) the study of DNA damages and their repair; 2) mutations in tumor suppressor genes and radiation-induced oncogene expression; 3) the role of growth factors and cytokines; 4) violation of the cell cycle; 5) elucidation of the mechanisms of apoptosis and necrosis. This review aimed to provide a theoretical basis, which may improve the sensitivity of cancer cells to radiotherapy. It focuses on the roles of tumor metabolism, DNA repair capacity, cell cycle checkpoints, and the tumor microenvironment in the development of radioresistance of cancer cells. Understanding the molecular alterations that lead to radioresistance may provide new diagnostic markers and therapeutic targets to improve radiotherapy efficacy.
THE ROLE OF PEPSINOGENS IN THE FORMATION OF GERD IN PATIENTS WITH COPD
Authors: Lіakh Olesіa , Tovt-Korshуnska Marianna
Published: January 2022

The article presents data on the role of pepsinogen-1 and -2 and bilirubin in the formation of gastroesophageal reflux disease (GERD) in patients with chronic obstructive pulmonary disease (COPD). Clinical, biochemical, immunological research methods were used in the work. The activity of pepsinogens 1 and 2 and bilirubin in saliva was determined in all patients with combined pathology. It has been established that the presence of concomitant GERD in patients is an independent aggravating factor for the function of external respiration. In patients with concomitant GERD, a significant increase in acute phase parameters in the serum, indicating active systemic inflammation. Increased activity of the cytokine IL-6 and IFNγ indicates the activation of the cellular immune system, with an unregulated immune response that supports chronic inflammation in the bronchi even in remission. Increased levels of IL-4 are compensatory in nature, as IL-4 inhibits the production of macrophages of proinflammatory cytokines, including IL-6. Detection of correlations between the concentration of total bilirubin in saliva with a decrease in external respiration, namely FVC, FEV-1, as well as the presence of shortness of breath allows us to consider bilirubin as a possible marker of reflux and respiratory inflammation in the bronchi, until obstruction. The positive correlation of pepsinogen-1 in saliva with an allergic history, and pepsinogen-2 in saliva with cough, shortness of breath and smoking, and a negative correlation of pepsinogen-1 with the value of FEV1 / FVC, allows to consider pepsinogen-1 and pepsinogen-2 as markers of non-acid reflux and respiratory inflammation with bronchoobstruction