bluuebunny/crossref_metadata_2025 huggingface dataset:
Two new species of Metacyclops Kiefer, 1927 (Copepoda, Cyclopoida) from Thailand and an up-to-date key to the species recorded in Asia
Authors: Athibai Sujeephon , Wongkamhaeng Koraon , Boonyanusith Chaichat
Published: January 2022

Metacyclops sakaeratensis sp. nov. and M. brancelji sp. nov. are described as being present in the mountainous areas of Northeastern and Southern Thailand, respectively. Two new species resemble M. woni in both sexes, but they are easily distinguished from their Cambodian relative by having: 1) transverse suture on the dorsal surface of the genital double-somite, 2) serrated hyaline frill on the posterior margin of third pedigerous somite, 3) different length / width ratio of caudal ramus, and 4) a row of spinule on caudal surface of intercoxal sclerite of the third swimming legs. The significant differences between M. sakaeratensis sp. nov. and M. brancelji sp. nov. are present in both sexes, including the body size, integumental ornamentation of the body surface, length / width ratio of caudal ramus, armature of the fifth swimming leg, and the male sixth swimming leg. In addition, an up-to-date key to the female of all fifteen species of Metacyclops recorded in Asia is provided.
Prolegômenos de uma teoria enunciativa da educação popular
Authors: Alcantara Marcos Angelus Miranda de , Carlos Erenildo João
Published: January 2022

A Educação Popular (EP) é uma pedagogia que aparece na teia social da América Latina. Do ponto de vista da experiência histórica, seus princípios sustentam os trabalhos de base nos anos 1960 e 1970, conforme Freire (1987), Brandão (2006) e Carrillo (2013) afirmam. Este escrito objetiva compartilhar alguns resultados da tese de doutoramento Elementos para uma Teoria Enunciativa da Educação Popular. No plano teórico/metodológico a análise toma por base algumas das ideias de Michel Foucault (2008) e está centrada nos elementos constitutivos em um conjunto de enunciados da EP. Dessa análise resulta a ideia de que o discurso atravessa a camada linguística e sócio-histórica desses enunciados. Verifica-se que o discurso analisado produz modos de falar, de articular e de escrever sobre EP, identificáveis mediante uma série de signos, vinculados à EP. Os resultados apontam, portanto, que o discurso da EP na América Latina se assenta em uma série de princípios éticos, políticos e epistemológicos que lhe conferem um modo de existência particular.
Uma análise da implementação do contraturno nas escolas municipais de Belo Horizonte
Authors: Silva Marcília de Sousa , Isayama Hélder Ferreira , Costa Luciana Assis
Published: January 2022

Os programas de contraturno desenvolvidos nas escolas municipais de Belo Horizonte/MG, mais especificamente, os Programas Escola Integrada e Segundo Tempo interagem com a dinâmica escolar e, por vezes, provocam justaposição na concretização de suas ações. O objetivo deste estudo foi investigar a implementação desses programas por meio de pesquisa bibliográfica e estudo de caso. A técnica de coleta foi a entrevista com coordenadores dos programas, pais, estudantes e educadores. A pesquisa baseou-se no ciclo de política e estudos do discurso para refletir as práticas políticas e sociais desenroladas na dinâmica escolar. Na análise da implementação os vínculos profissionais podem oferecer fragilidades na efetivação da política bem como provocar tensões no universo da gestão local e central dos programas que estruturam o contraturno escolar. Ademais, as concepções dos sujeitos envolvidos impactam nos resultados da política. Nesse sentido, este estudo contribui para as possibilidades de abertura de interpretações dos diversos sujeitos que participam da comunidade escolar oportunizando a autoria das vozes e protagonismo coletivo no caminho da construção de “encontros potentes”.
Análise de trabalhos que abordam a relação entre Neurociências e Educação no período de 2014 a 2019 e suas interfaces com o Ensino de Ciências/Química
Authors: Costa Amanda Cristina Magalhães , Souza Vinícius Catão de Assis
Published: January 2022

Pesquisas recentes indicam que as Neurociências podem trazer importantes contribuições à Educação, disponibilizando conhecimentos com base científica que fomentam reflexões sobre os processos de ensino e aprendizagem e, consequentemente, a busca por aprimorar práticas pedagógicas instituídas em Escolas e Universidades. Nesse sentido, o presente trabalho analisou algumas publicações que propuseram relacionar as Neurociências com a Educação e o ensino de Ciências. Para tal, realizou-se inicialmente um levantamento bibliográfico utilizando a plataforma Google Acadêmico e o Portal de Periódicos CAPES, sendo definidas as palavras-chaves para efetuar tais buscas. Em seguida, delimitou-se a amostra a ser analisada, que teve como recorte as publicações entre 2014 e 2019 resultantes apenas do Portal da CAPES, considerando o vasto retorno obtido no Google Acadêmico e a necessidade de limitar os dados. Posteriormente, os trabalhos selecionados foram analisados e classificados como alinhados ou não às temáticas de busca, sendo esta seleção validada pela triangulação dos dados entre os pesquisadores. Os trabalhos da amostra classificados como não alinhados foram submetidos à análise de conteúdo proposta por Bardin, gerando categorias que evidenciaram a importância das Neurociências como campo de conhecimento que integra diferentes áreas. Por fim, os dados selecionados foram dispostos em gráficos e tabelas para, em seguida, discutir os resultados apontando as possíveis implicações da interface entre Neurociências e Educação com o Ensino de Ciências, além deprojetar perspectivas futuras de pesquisas. A partir dos resultados, constatou-se a necessidade de estimular um maior diálogo entre essas áreas de conhecimento, buscando contemplar a formação dos professores em geral.
Educação Física decolonial: análise, desafios e perspectivas em Paulo Freire e Frantz Fanon
Authors: Sousa Cláudio Aparecido , Costa Thiago Batista , Ehrenberg Mônica Caldas
Published: January 2022

O objetivo do presente ensaio teórico é apresentar a perspectiva a Educação Física decolonial, inspirada na teoria de Paulo Freire e Frantz Fanon, possibilitando uma reflexão teórica diante da justiça social e o reconhecimento da identidade negra na sociedade e, ainda, verificar se existem discussões teóricas nessa área sobre a temática. O estudo em questão está amparado especialmente em uma visão crítica de mundo e educacional, no qual está estreitamente apoiada nos conceitos de educação popular e justiça social, amparada na visão decolonial de Freire e Fanon e não tem a pretensão de apresentar um modelo curricular para o componente curricular Educação Física. No entanto, entendemos que é necessário realizar uma reflexão sobre autores e perspectivas teóricas que ainda não adentraram nas discussões desta área do conhecimento. Os resultados da literatura permitiram constatar que a perspectiva decolonial de Freire e Fanon ainda não foram estudadas e introduzidas no debate da área de Educação Física. Concluímos que, é a partir do reconhecimento de uma perspectiva decolonial para a Educação Física que as oportunidades de emancipação social e libertação do sistema colonial poderão oferecer subsídios de esperança para as pessoas subalternas da sociedade.
Letramentos dos corpos: direitos linguísticos e existenciais das pessoas negras surdas
Authors: Santos Icaro Augusto , Rezende Tânia Ferreira
Published: January 2022

O capitalismo, criado com a colonialidade, utiliza-se da dominação da natureza e tudo o que dela faz parte para a manutenção desse sistema econômico mundial. A colonialidade implementa a tecnologia da dominação e da exploração dos corpos e com suas intersecções, uma vez que é impossível a fragmentação do corpo. O objetivo central desta discussão é suscitar a reflexão sobre como os corpos de pessoas negras surdas, situados no sistema-mundo, estruturado pela colonialidade e pelo capitalismo neoliberal, enunciam sentidos, tencionando, assim, as relações de poder nas quais se envolvem. O sistema-mundo é opressor e subalterniza as pessoas negras surdas, impondo-lhes visões branco-ouvintistas para a manutenção da supremacia da colonialidade. Nosso pressuposto é que a subalternização e a dominação de seus corpos estão ligadas à negação dos direitos linguísticos e existenciais da população negra surda brasileira, como um todo. Esse pressuposto se sustenta na revisão da literatura que aborda a intersecção das questões de raça, surdez e direitos linguísticos. A partir das referências selecionadas, foram sintetizadas reflexões teóricas que possibilitam evidenciar a colisão das estruturas de cultura/linguagem/epistemologia, raça/cor, gênero/sexualidade, classe e outras categorias de classificação de identificação sociais. No final, foi possível constatar que a opressão e marginalização dos corpos das pessoas negras surdas são resultantes das colisões criadas pelo racismo estrutural, criado pela colonialidade e mantido pelo capitalismo globalizado, reverberando, assim, a negação dos direitos linguísticos e existenciais de pessoas negras surdas.
Insatisfação com a massa corporal e uso de suplementos alimentares em frequentadoras de academias de ginástica em Juiz de Fora - MG
Authors: Rosa Junior Carlos Roberto Ramos da , Viana Jéssica Fernades , Souza Marina Rodrigues Vieira de , Ferreira Maria Elisa Caputo
Published: January 2022

O objetivo deste estudo foi verificar a associação entre insatisfação com a massa corporal e o uso de suplementos alimentares em mulheres que frequentam academias de ginástica em Juiz de Fora, MG. Os dados foram coletados em sete estabelecimentos. A insatisfação com a massa corporal foi avaliada pela diferença entre a massa corporal considerada ideal para si mesma e a massa corporal auto referida. De acordo com os resultados, conclui-se que a maior parte das mulheres apresentou insatisfação com a massa corporal, assim como mais de um terço utilizou suplementos alimentares, porém essas variáveis não estavam correlacionadas.
Educação profissional tecnológica: uma revisão acerca da formação continuada de professores(as)
Authors: Keller Raiara Valau , Becker Eriques Piccolo , Sawitzki Rosalvo Luis , Martiny Luis Eugênio , Almeida Callai Ana Nathalia
Published: January 2022

O presente estudo busca analisar a formação docente para atuação na Educação Profissional Tecnológica (EPT), além de discutir Formação Continuada (FC) de professores de Educação Física nessa modalidade de ensino. Para isso, foi realizado uma análise histórica da EPT, a Formação continuada e a implicação no trajeto formativo. Para o desenvolvimento deste estudo, foi utilizada uma pesquisa bibliográfica. Por fim, evidenciou-se a necessidade de se construir e/ou possibilitar espaços de FC para que os professores da EPT se instrumentalizem para enfrentar as peculiaridades referentes a esta modalidade de ensino e, assim, poder pensar sua prática pedagógica.
A atividade física para gestantes: análise da formação específica
Authors: Scherer Alexandre , Oliveira Marcella Souza Massa Pires de , Scherer Fernanda Mariana
Published: January 2022

Este estudo de cunho qualitativo objetivou compreender que tipo de formação tem os profissionais de Educação Física que trabalham com gestantes. Inicialmente, refletiu-se sobre a gestação, suas características, a influência dos exercícios físicos e a formação profissional. Foi utilizada a entrevista semiestruturada e a análise de currículos em Educação Física. As informações foram categorizadas. As conclusões apontam que os conhecimentos relevantes para a intervenção com grávidas estão ligados aos aspectos biológicos e de treinamento físico e se efetivam mais expressivamente através de cursos de extensão e pela experiência no acompanhamento do processo de gestação.
O efeito da prática do rapel por estudantes de Educação Física na transformação da percepção do esporte
Authors: Triani Felipe , Silva Leonardo Rosendo da , Silva Anderson José da
Published: January 2022

O estudo objetivou conhecer e analisar os efeitos da prática do rapel por estudantes de um curso de bacharelado em Educação Física na transformação da percepção do esporte. Participaram 30 alunos por meio de uma entrevista após a vivência do rapel. Os resultados apontaram para a presença de três elementos: o risco, presente por meio da experimentação do medo; a satisfação, pela experimentação do prazer vivido; e a superação de limites, revelada no sucesso em concluir a prática. A vivência do rapel teve como efeito a transformação da percepção que os participantes tinham sobre o esporte.
Educação Infantil e Pedagogia Histórico- Crítica: apontamentos sobre a educação escolar
Authors: Monteiro Fernanda Yully dos Santos
Published: January 2022

O texto apresenta como objeto de reflexão a educação infantil e as teorias pedagógicas do “aprender a aprender” atreladas ao construtivismo e pós-modernismo, que fazem parte de um processo intencional de desescolarização das crianças de zero a cinco anos. Como método de elaboração do conhecimento, utiliza-se o materialismo histórico dialético e a pedagogia histórico-crítica como arcabouço teórico/metodológico que permite compreender a essência do objeto. Enquanto resultados da pesquisa aponta-se que a pedagogia histórico-crítica é uma teoria do conhecimento contra-hegemônica que pode balizar o ensino da educação infantil, uma teoria que busca ascender e superar o senso comum através da apropriação do conhecimento elaborado na escola.
Filosofia no Novo Ensino Médio: BNCC e os 17 Objetivos de Desenvolvimento Sustentável
Authors: Frau Erica Cristina , Silva Paulo Rogério da , Araujo Daniel José de
Published: January 2022

Este artigo tem como objetivo apontar algumas reflexões sobre as mudanças ocorridas no Novo Ensino Médio, mais especificamente na estrutura do Ensino de Filosofia a partir da homologação da BNCC em 2018, e estabelecer as relações entre os componentes curriculares da Área de Ciências Humanas e Sociais Aplicadas, e da Área de Ciências da Natureza e suas Tecnologias. Para isso, são apresentados alguns aspectos essenciais da Declaração Universal dos Direitos Humanos (DUDH) e dos 17 Objetivos de Desenvolvimento Sustentável (ODS) propostos pela Organização das Nações Unidas (ONU), e a integração dessas áreas a partir das escolhas dos estudantes e da flexibilização dessa nova estrutura para o Ensino Médio por meio dos Itinerários Formativos. Por fim, apresentamos algumas reflexões sobre como as especificidades do ensino de Filosofia poderão resistir no Novo Ensino Médio, resgatando a condição humana e a importância da Declaração Universal dos Direitos Humanos (DUDH) para assegurar essa articulação.
Prelúdios das proposições para a Filosofia na Reforma do Ensino Médio em Santa Catarina
Authors: Oliari Gilberto
Published: January 2022

O presente artigo tem como objetivo sistematizar e apresentar o processo inicial de constituição da Base Curricular do Ensino Médio do Território Catarinense, proposto a partir da reforma dessa etapa da Educação Básica. Nesse sentido, busca-se expor alguns encaminhamentos realizados pela Secretaria de Estado da Educação de Santa Catarina - SED/SC, referentes a construção e disponibilização para consulta pública do documento intitulado ‘Marco Zero: Currículo Base do Ensino Médio do Território Catarinense’. Além disso, sistematiza-se algumas inspirações gerais para a Filosofia, bem como objetos do conhecimento e as habilidades trazidas no respectivo ‘Marco Zero’, no tocante ao ensino de Filosofia. Conclui-se problematizando o alinhamento dessa proposição curricular com a Base Nacional Comum Curricular - Ensino Médio.
La Commemoratio Annuntiationis y la figura de san Ildefonso de Toledo en las Vitae sanctorum de Rodrigo de Cerrato. Su relación con la literatura hispánica del siglo XIII
Authors: BOHDZIEWICZ Olga Soledad
Published: January 2022

By considering in the first place Rodrigo of Cerrato’s hagiographic compilation, this paper aims to analyze the Commemoratio Anuntiationis and the representation of Ildephonsus of Toledo, the saint to whom the creation of this Marian celebration is ascribed. In connection with the Vitae sanctorum, we will also take into account other compilations, both in Latin and Romance languages, in order to find their sources, their combination and inclusion into the text, as well as the different ways they are handled in each case. This will contribute to verify the continuity of this visgothic Marian feast up to 13th century as well as to show the hesitations regarding its aim.

Partiendo de la compilación hagiográfica de Rodrigo de Cerrato, este trabajo propone analizar la Commemoratio Annuntiationis y la figura del santo al que se atribuye la instauración de esta celebración mariana, Ildefonso de Toledo. En conexión con las Vitae sanctorum consideraremos también otras compilaciones, tanto en lengua latina y romance, con el objeto de determinar las fuentes, su combinación e inserción en el texto y el diverso tratamiento que éstas reciben en cada caso. Ello contribuirá a verificar la continuidad de esta festividad mariana de tradición visigótica en el siglo XIII y a poner de relieve las vacilaciones que se produjeron en cuanto a su objeto.
La hacienda y fortuna de don Ruy López Dávalos, condestable de Castilla
Authors: CARMONA RUIZ María Antonia
Published: January 2022

This article aims to analyse the formation and evolution of Ruy López Dávalos' estate, from his arrival at the Castilian court during the reign of Juan I, being especially favoured by Enrique III with important posts, an extensive lordship and other economic assets that he used to expand his patrimony. His fall from grace during the minority of John II meant that his assets were confiscated and distributed among important members of the king's household. His sons tried unsuccessfully to recover this capital, even making their hypothetical distribution.

A través de este trabajo pretendemos analizar la formación y evolución de la hacienda de Ruy López Dávalos, a partir de su llegada a la corte castellana durante el reinado de Juan I, viéndose especialmente favorecido por Enrique III con importantes cargos, un extenso señorío y otros bienes económicos que utilizó para ampliar su patrimonio. Su caída en desgracia durante la minoría de edad de Juan II supuso la confiscación de sus bienes que se repartieron entre importantes miembros de la casa del rey. Sus hijos intentaron sin éxito recuperar ese capital, realizando incluso su hipotético reparto.
La langue française, un vecteur de « l’être-les-uns-avec-les-autres » chez Fatou Diome et Léonora Miano
Authors: Koumba Rolph Roderick , Kouakou Ama Brigitte
Published: January 2022

La question de l’utilité du français comme langue de communication ne semble plus se poser aujourd’hui. Même si certains pensent que c’est une propriété exclusive des pays qui l’ont comme legs ancestral : il s’agit ici de la France. Et que d’autres, à contre-courant, y voient un instrument d’aliénation culturelle des locuteurs francophones des ex-colonies de la France. Pour en finir avec ces débats « stériles » qui détourent les regards sur l’indispensabilité du français en Afrique et dans le monde, Fatou Diome et Léonora Miano démontrent respectivement dans leurs œuvres d’une part, que cette langue est un instrument au service de la construction d’une altérité positive dans l’espace francophone. Et, d’autre part, que c’est un moyen de communication permettant la rencontre des peuples en Afrique subsaharienne francophone. D’un commun accord, elles pensent que le français est « une langue africaine à part entière ».
Évitons de respirer l'air du temps
Authors: Mavrikakis Catherine
Published: January 2022

Nouvelle qui traite d'une irritation envers le discours sur le sida à l'heure actuelle.
“¡Qué enfermedad tan sublime!”: ‘Une visite inopportune’ [1988] de Copi o la “comedia de la muerte”
Authors: Vásquez Sáenz Henry Ferney
Published: January 2022

Le 11 décembre 1987, Copi, mourant de la nouvelle maladie qui terrorise le monde, et ayant gagné l’estime de plus d’un intellectuel, reçoit le Grand Prix de Littérature Dramatique décerné par la Ville de Paris. Malheureusement, trois jours plus tard, le 14 décembre, il décède à l’hôpital Claude-Bernard à Paris. Copi était conscient de l’arrivée d’une « visite » qui l’amènera à créer l’une de ses meilleures pièces : Une visite inopportune [1988]. Dans cette étude, nous voulons commémorer, d’une certaine manière, l’ingéniosité créative avec laquelle Copi a affronté son agonie due au sida et mettre en évidence la validité d’une pièce autobiographique créée au milieu d’une maladie qui condamne les homosexuels dans les années 1980, en France (et dans le monde entier). D’abord, nous tenterons de contextualiser brièvement les premières années de la pandémie en France afin de mettre en relation cette pièce avec l’écriture du sida. Ensuite, nous analyserons les ressources dramaturgiques que Copi a utilisées avec humour pour mettre en scène « l’anniversaire de mon sida » et nous mettrons en évidence l’importance de cette subversive « comédie de la mort ».
308-nm excimer laser in the treatment of a localized recalcitrant form of perioral dermatitis: Case report
Authors: Queirós Catarina , Uva Luís , Filipe Paulo
Published: January 2022

In the last two decades, 308-nm excimer laser has been increasingly recognized as a therapeutic alternative for several dermatological conditions, being currently FDA approved for the treatment of localized vitiligo and moderately severe localized psoriasis unresponsive to topical treatments. We describe the case of a 17-year-old with a recalcitrant form of dermatitis occupying the entire perioral region, previously unresponsive to several treatments, who was treated with 308-nm excimer laser with an excellent result. 308-nm monochromatic excimer laser has several advantages over other types of phototherapy, including lower UV dose exposure, shorter courses of therapy and a better sparing of adjacent tissue. Although infrequently used, 308-nm excimer laser certainly has a vast potential in Dermatology, particularly regarding recalcitrant and localized inflammatory conditions, such as the one we present.
Walter da Silveira e o cinema moderno no Brasil: críticas, artigos, cartas, documentos
Authors: Nogueira Cyntia
Published: January 2022

O livro apresenta os artigos de Walter da Silveira (1915 – 1970) sobre o cinema no Brasil e na Bahia, escritos entre 1943 e 1970. Ao lado de um conjunto relevante de críticas, ensaios, conferências e teses do autor, incluindo seleção de seus textos teóricos, estão reunidas na obra as cartas trocadas com dois outros críticos e historiadores do cinema brasileiro, Alex Viany e Paulo Emílio Sales Gomes, e com o crítico e cineasta Glauber Rocha. Além disso, documentos, fortuna crítica e um dossiê de artigos inéditos visam apresentar e contextualizar a importância de suas ações e pensamento para o desenvolvimento das ideias sobre cinema independente e para afirmação da crítica e do cinema modernos.
Correlative all-optical quantification of mass density and mechanics of subcellular compartments with fluorescence specificity
Authors: Schlüßler Raimund , Kim Kyoohyun , Nötzel Martin , Taubenberger Anna , Abuhattum Shada , Beck Timon , Müller Paul , Maharana Shovamaye , Cojoc Gheorghe , Girardo Salvatore , Hermann Andreas , Alberti Simon , Guck Jochen
Published: January 2022

Quantitative measurements of physical parameters become increasingly important for understanding biological processes. Brillouin microscopy (BM) has recently emerged as one technique providing the 3D distribution of viscoelastic properties inside biological samples − so far relying on the implicit assumption that refractive index (RI) and density can be neglected. Here, we present a novel method (FOB microscopy) combining BM with optical diffraction tomography and epifluorescence imaging for explicitly measuring the Brillouin shift, RI, and absolute density with specificity to fluorescently labeled structures. We show that neglecting the RI and density might lead to erroneous conclusions. Investigating the nucleoplasm of wild-type HeLa cells, we find that it has lower density but higher longitudinal modulus than the cytoplasm. Thus, the longitudinal modulus is not merely sensitive to the water content of the sample − a postulate vividly discussed in the field. We demonstrate the further utility of FOB on various biological systems including adipocytes and intracellular membraneless compartments. FOB microscopy can provide unexpected scientific discoveries and shed quantitative light on processes such as phase separation and transition inside living cells.
RNA N6-methyladenosine modulates endothelial atherogenic responses to disturbed flow in mice
Authors: Li Bochuan , Zhang Ting , Liu Mengxia , Cui Zhen , Zhang Yanhong , Liu Mingming , Liu Yanan , Sun Yongqiao , Li Mengqi , Tian Yikui , Yang Ying , Jiang Hongfeng , Liang Degang
Published: January 2022

Atherosclerosis preferentially occurs in atheroprone vasculature where human umbilical vein endothelial cells are exposed to disturbed flow. Disturbed flow is associated with vascular inflammation and focal distribution. Recent studies have revealed the involvement of epigenetic regulation in atherosclerosis progression. N6-methyladenosine (m6A) is the most prevalent internal modiﬁcation of eukaryotic mRNA, but its function in endothelial atherogenic progression remains unclear. Here, we show that m6A mediates the epidermal growth factor receptor (EGFR) signaling pathway during EC activation to regulate the atherosclerotic process. Oscillatory stress (OS) reduced the expression of methyltransferase like 3 (METTL3), the primary m6A methyltransferase. Through m6A sequencing and functional studies, we determined that m6A mediates the mRNA decay of the vascular pathophysiology gene EGFR which leads to EC dysfunction. m6A modification of the EGFR 3’ untranslated regions (3’UTR) accelerated its mRNA degradation. Double mutation of the EGFR 3’UTR abolished METTL3-induced luciferase activity. Adenovirus-mediated METTL3 overexpression significantly reduced EGFR activation and endothelial dysfunction in the presence of OS. Furthermore, thrombospondin-1 (TSP-1), an EGFR ligand, was specifically expressed in atheroprone regions without being affected by METTL3. Inhibition of the TSP-1/EGFR axis by using shRNA and AG1478 significantly ameliorated atherogenesis. Overall, our study revealed that METTL3 alleviates endothelial atherogenic progression through m6A-dependent stabilization of EGFR mRNA, highlighting the important role of RNA transcriptomics in atherosclerosis regulation.
Comparative transcriptomic analysis reveals translationally relevant processes in mouse models of malaria
Authors: Georgiadou Athina , Dunican Claire , Soro-Barrio Pablo , Lee Hyun Jae , Kaforou Myrsini , Cunnington Aubrey J
Published: January 2022

Recent initiatives to improve translation of findings from animal models to human disease have focussed on reproducibility but quantifying the relevance of animal models remains a challenge. Here, we use comparative transcriptomics of blood to evaluate the systemic host response and its concordance between humans with different clinical manifestations of malaria and five commonly used mouse models. Plasmodium yoelii 17XL infection of mice most closely reproduces the profile of gene expression changes seen in the major human severe malaria syndromes, accompanied by high parasite biomass, severe anemia, hyperlactatemia, and cerebral microvascular pathology. However, there is also considerable discordance of changes in gene expression between the different host species and across all models, indicating that the relevance of biological mechanisms of interest in each model should be assessed before conducting experiments. These data will aid the selection of appropriate models for translational malaria research, and the approach is generalizable to other disease models.
Myelination synchronizes cortical oscillations by consolidating parvalbumin-mediated phasic inhibition
Authors: Dubey Mohit , Pascual-Garcia Maria , Helmes Koke , Wever Dennis D , Hamada Mustafa S , Kushner Steven A , Kole Maarten HP
Published: January 2022

Parvalbumin-positive (PV+) γ-aminobutyric acid (GABA) interneurons are critically involved in producing rapid network oscillations and cortical microcircuit computations, but the significance of PV+ axon myelination to the temporal features of inhibition remains elusive. Here, using toxic and genetic mouse models of demyelination and dysmyelination, respectively, we find that loss of compact myelin reduces PV+ interneuron presynaptic terminals and increases failures, and the weak phasic inhibition of pyramidal neurons abolishes optogenetically driven gamma oscillations in vivo. Strikingly, during behaviors of quiet wakefulness selectively theta rhythms are amplified and accompanied by highly synchronized interictal epileptic discharges. In support of a causal role of impaired PV-mediated inhibition, optogenetic activation of myelin-deficient PV+ interneurons attenuated the power of slow theta rhythms and limited interictal spike occurrence. Thus, myelination of PV axons is required to consolidate fast inhibition of pyramidal neurons and enable behavioral state-dependent modulation of local circuit synchronization.
Archerfish number discrimination
Authors: Potrich Davide , Zanon Mirko , Vallortigara Giorgio
Published: January 2022

Debates have arisen as to whether non-human animals actually can learn abstract non-symbolic numerousness or whether they always rely on some continuous physical aspect of the stimuli, covarying with number. Here, we investigated archerfish (Toxotes jaculatrix) non-symbolic numerical discrimination with accurate control for covarying continuous physical stimulus attributes. Archerfish were trained to select one of two groups of black dots (Exp. 1: 3 vs 6 elements; Exp. 2: 2 vs 3 elements); these were controlled for several combinations of physical variables (elements’ size, overall area, overall perimeter, density, and sparsity), ensuring that only numerical information was available. Generalization tests with novel numerical comparisons (2 vs 3, 5 vs 8, and 6 vs 9 in Exp. 1; 3 vs 4, 3 vs 6 in Exp. 2) revealed choice for the largest or smallest numerical group according to the relative number that was rewarded at training. None of the continuous physical variables, including spatial frequency, were affecting archerfish performance. Results provide evidence that archerfish spontaneously use abstract relative numerical information for both small and large numbers when only numerical cues are available.
Estrategia híbrida en el manejo de cardiopatías congénitas. Resultados iniciales en una experiencia multicéntrica
Authors: Daghero Luciana , Diaz Juan , Scauso Fernanda , Bueno Nora , Azar Irma , Contreras Alejandro , Banille Edgardo , Molinas Rodrigo , Juaneda Ignacio , Peirone Alejandro
Published: January 2022

Background: The hybrid approach implies the close collaboration between surgical and interventional cardiology teams for the treatment of complex congenital heart diseases to reduce the number of interventions by using less invasive techniques, avoid the limitations due to the size of vascular accesses and the use of cardiopulmonary bypass. Objectives: The aim of this study is to evaluate the indications, techniques, initial results and short-term follow-up of the hybrid approach. Methods: We conducted a retrospective analysis of patients treated with hybrid approach between March 2014 and September 2020. Fourteen procedures were performed in 13 patients. Mean age was 16.8 years (1 day-13 years); 50% were neonates, 57% were male and mean weight was 9 kg (1.9-70 kg). The hybrid procedures performed included stenting in coarctation of the aorta (4 patients), ductal stenting (3 patients), stenting of pulmonary artery branches (1 patient), neonatal aortic valvuloplasty (4 patients) and perventricular closure of muscular ventricular septal defect (2 patients). The access used was dissection of the carotid artery in 8 procedures and sternotomy in the remaining 6. Results: All the procedures were successfully completed, except for two patients: one died due to ventricular fibrillation after the procedure, and another in the immediate postoperative period due to severe coagulation abnormality. Mean follow-up of the remaining 12 patients was 19 months with favorable outcome. Conclusions: The initial results with the use of a hybrid strategy were satisfactory in terms of survival and improvement of the hemodynamic parameters. The selection of cases, teamwork and appropriate follow-up are key factors to achieve satisfactory results.
Electrocardiogramas durante el tercer trimestre de embarazo: descripción de sus características
Authors: Battioni Luciano , Eidelman Gabriel , Enriquez Brian , Herscovich Nicolás , Arismendi Lorena , Deviggiano Alejandro
Published: January 2022

Objective: The aim of this study was to analyze the electrocardiographic characteristics in pregnant women without cardiovascular disease. Methods: This was a descriptive, cross-sectional, multicenter study, including patients without cardiovascular disease in their third trimester of pregnancy, who underwent cardiac evaluation before delivery between April and July 2020. All patients signed the corresponding informed consent. Results: A total of 80 tracings were analyzed. Median heart rate was 82 bpm (IQR 70-93 bpm) and median QRS axis was 54° (IQR 39°-71°). Q waves and ST segment depression were relatively frequent in inferior leads and from V4 to V6. Median QTc was 422 msec (IQR 404-445 msec) and median time from T wave peak to T wave end was 86 msec (IQR 74-95 msec). Conclusion: The most common changes occurred in T wave peak to T wave end and from V4 to V6. Main changes included q waves and ST-segment depression. Axis deviations, sinus tachycardia or prolonged QTc were rare
Isolation of mecC Gene carrying Methicillin Resistant Staphylococcus aureus in Clinical Samples from a Tertiary Care Institute, Northern India
Authors: Bali Nargis , Borkakoty Biswajyoti , Bashir Humaira , Nazir Shaista , Wani Sayim , Mir Anjum , Hazarika Rahul
Published: January 2022

Introduction: The MecC Methicillin Resistant Staphylococcus aureus (MRSA) after its initial recovery in 2007 has been reported with varying frequency from different parts of the world. These isolates assume importance due to the fact that with routine testing platforms available for the detection of MRSA they can be misidentified as being methicillin sensitive which can adversely affect the treatment and outcome of infections due to MRSA harbouring the mecC gene. Aim: To evaluate mecC gene carrying MRSA in clinical isolates. Materials and Methods: This retrospective study was conducted in the Department of Microbiology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India for a period of three months (May-July 2020). A total of 102 laboratory confirmed isolates of MRSA (based on biochemical tests and cefoxitin disc diffusion results) were subjected to screening for the presence of mecA and mecC gene by Polymerase Chain Reaction (PCR). Deoxyribonucleic Acid (DNA) was extracted using an in house extraction method following which mecA and mecC were amplified in a total reaction volume of 25 μL using 2x PCR master mix, 5 μL of template and 1 μL (0.4 μM final concentration) each of reverse and forward primers specific for the above mentioned genes. Statistical analysis was done using Statistical Package for the Social Sciences (SPSS) software v24.0. Results: All the isolates were confirmed as being methicillin resistant with 96.1% isolates carrying the mecA gene and 3.9% carrying the mecC gene. The mecC MRSA were recovered from pus, swab and endotracheal tip in middle aged men. One of the patient from whose sample mecC MRSA was recovered was suffering from hypertension, diabetes and renal faliure. MRSA exhibited high resistance to all the antimicrobial agents tested however all of them were sensitive to vancomycin and linezolid. Conclusion: The presence of mecC gene in clinical isolates of MRSA is a cause of concern and calls for an extensive and continuous surveillance of such isolates as they can in future be implicated in causing severe human infections.
COMPARISON OF HEPATOPROTECTIVE ACTIVITY OF NISHA LAUHA (NL) AND NISHA LAUHA WITHOUT LAUHA BHASMA (NLWL) AGAINST CCL4 INDUCED HEPATOTOXICITY IN WISTAR RATS
Authors: Sheshrao Adhave Swati , Kundlikrao Ingole Rajesh
Published: January 2022

Introduction: Many herbal drugs are used to treat liver diseases, but the dose of the herbal drug is high, and they have lesser palatability. An ideal medicine is a medicine that is effective, easy palatable and produces quick action in a low dose. It is possible by adding metals like Lauha (Iron) to the herbal drugs. Objective: To compare the hepatoprotective effect of Nisha Lauha (NL) and Nisha Lauha without Lauha Bhasma (NLWL) in experimental rats. Materials and methods: 40 rats were taken divided into five groups, and each group contained eight rats. Among these groups, four groups receive 0.2 ml of injection containing the 0.1 ml CCL4 plus 0.1 ml liquid paraffin given intraperitoneally for 28 days to induce Hepatotoxicity. Both Test groups received NL and NLWL at a dose of 45mg/kg bd. wt. and 450mg/kg bd. wt. respectively for 28 days. The standard group receives silymarin at a 100 mg/kg bd dose. wt. for 28 days by oral route. The hepatoprotective effect was analyzed using biochemical parameters and histopathological study of the liver. Results: Both the Test and standard groups do not show toxic effects against CCL4 induced hepatotoxicity and lower the dose of the herbal drug due to the addition of Lauha. Conclusion: The result suggests that both test group NL and NL without Lauha Bhasma shows the hepatoprotective activity as equivalent to standard drug silymarin. The addition of Lauha Bhasma to herbal drugs decreases the dose without affecting the drug’s efficacy against the hepatoprotective effect.
A CRITICAL REVIEW OF VATIKA HRIDROGA WITH SPECIAL REFERENCE TO ISCHEMIC HEART DISEASE
Authors: Jaiswal Anchal , Singh Sanjay Kumar , Joshi Seema
Published: January 2022

Given increasing evidence, most deaths are due to non-communicable diseases; half of them are the cardiovascular disease. Hridaya is moolasthana of pranvavaha and rasavaha strotas. According to Acharya Sushruta, any condition that produces disturbance in the heart is Hridroga. It is classified into five types. Vataja Hridroga is characterized by Ruja in Urah Pradesha (Pain in the chest region). Vatika type seems to have conceived the disease entity correlated with ischemic heart disease. None of the other Cardiac afflictions appears to have been described under Hridroga. The prevalence rate in the younger age group is increasing day by day so, we need to know the detailed knowledge of vatika hridroga
A REVIEW ON ANALYSIS OF THERAPEUTIC PROCEDURE OF SHIRODHARA AND ITS PROBABLE MODE OF ACTION
Authors: Kotwal Sheweta , Pathak Deepak
Published: January 2022

Shirodhara is one of the four types of Murdha Taila, which involves a continuous impact of medicated oil due to gravity flow from a dhara pot at the height of 4 angulas through a wick on the forehead of the subject at a controlled temperature for a prolonged duration (approx. 30-45 min.). In today’s era, unhealthy lifestyle, stress, and anxiety lead to many problems like insomnia, headache, facial paralysis, scalp psoriasis, hair fall etc. There is a need for time to find out the safe and effective treatment modalities to combat these challenges from the treasures of Ayurveda. In Ayurveda, many Samhitas have mentioned procedural outcomes, but their mode of action is not mentioned anywhere. So a review study was conducted, and various Samhitas, Nighantus, research papers, scientific journals, and modern books were considered.
COMPARATIVE STUDY OF RASAYANAS DESCRIBED IN BRIHAT-TRAYI: A REVIEW
Authors: Gangwar Akanksha , Yadav S.S
Published: January 2022

Ayurveda is the science of life that is a means to attain long and healthy life, and human beings have cherished it since antiquity, and the use of Rasayanas is one of the simplest means to attain it. A detailed description of Rasayanas has been done in our classical ayurvedic texts. Rasayana is one of the eight important branches mentioned in Ashtanga Ayurveda. Different Niruktis and definitions of Rasayanas have been quoted in different ways in ayurvedic texts. Various classifications have been done, which helps understand the concept of Rasayanas in a detailed manner. The use of Rasayanas is considered to help achieve the main aim of Ayurveda of maintaining health and treatment of the diseased. Description of Achara Rasayana has been done, which is one of the means of rejuvenation of mind and soul. Rasayanas are a boon given to the world by Ayurveda to correct Dhatu vaishamya and attain Dhatu satmya.
ETIOPATHOGENESIS AND MANAGEMENT OF WAJAAL-MAFASIL (RHEUMATOID ARTHRITIS): AN EVIDENCE-BASED COMPREHENSIVE REVIEW
Authors: Maqbool Ahmad Ansari Umme Ammara , Uddin Qamar , Ismail Bhoraniya Abdullah , Jabeen Juveria
Published: January 2022

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by symmetrical inflammatory polyarthritis involving small joints of the hand and feet. It has a global prevalence of 0.8 to 1% in Europe and the Indian subcontinent. Rheumatoid arthritis (Waja‘al-Maf?sil) had been broadly described and managed by the Unani scholars since antiquity. Many pharmacological and non-pharmacological treatment methods are available in the classical Unani literature. The treatment differs for different varieties of morbid humour involved in disease pathogenesis. Treatment aims to reduce morbidity and prevent disability, subsequently improving the quality of life. This review article mainly highlights the management of rheumatoid arthritis mentioned in classical Unani literature and supportive scientific evidence of various preclinical and clinical studies suggesting the potential of Unani medicine. This review article aims to explore the concept of rheumatoid arthritis in the Unani system of medicine to provide a better understanding of disease and its management through the holistic policy of Unani medicine. This review may conclude that Unani treatment can form an alternative source to manage RA.
LIFESTYLE DISORDERS IN CHILDREN: AN AYURVEDIC OVERVIEW
Authors: Patni Kalpana , Gupta Anu
Published: January 2022

Lifestyle Disorders (LSD) are common problems among upper-middle and higher society children. Lifestyle has long been associated with the development of many chronic diseases. It affects both genders. WHO has recognized Noncommunicable diseases (NCDs), especially diabetes, obesity, cardiovascular disease, cancer, and chronic lung disease, have everyday lifestyle linked risk factors like lack of physical activity, unhealthy diet and feeding habits and harmful use of alcohol. Worldwide, the current scenario of NCDs is the primary cause of morbidity and mortality, even in young children. According to WHO Report 2004, these account for nearly 60% of deaths and 47% of the global burden of illness. The rise in NCDs is substantially accelerating in most developing countries like India. In India, 53% of the deaths in 2008 were due to NCDs, and cardiovascular disease (CVDs) alone accounted for 24% of deaths (WHO). In 2005 India experienced the highest loss in potentially productive years of life globally, and the leading cause of death was cardiovascular disease. The cumulative loss of national income for India due to NCDs mortality for 2006-2015 was around USD237 billion. By 2030, this productivity loss is estimated to double to 17.9 million years lost. These major NCDs are preventable through effective Ayurvedic interventions by judiciously treating lifestyle-related modifiable risk factors. This review confers the current scenario of NCDs in children and their Ayurvedic Management.
WhatsApp for Educational Purposes: Exploring Omani English Language Teachers` WhatsApp Use and Corresponding Beliefs
Authors: Al Mamari Nabhan , Dydowicz Jarek , Mirza Chahrazed
Published: January 2022

A growing body of research accentuates the potential of adopting social media platforms, including instant messaging applications in formal learning. This study aims to explore Omani English language teachers' use of WhatsApp in their teaching as well as their perspectives regarding its use. Twelve Omani English language teachers from various government schools were interviewed and a number of WhatsApp artifacts were collected. The data was analyzed using Thematic Content Analysis and focused on both the teachers’ beliefs and their use of the software. The study revealed that teachers’ employed WhatsApp for a number of educational purposes such as managing their classes, communicating with parents, improving particular language skills and providing ongoing assistance to support in-home learning. In addition, WhatsApp emerged as a means of developing and maintaining a Virtual Community of Practice (VCoP) in the participants' professional contexts which allowed for sustained continuous professional development of the participants. The research uncovered largely positive views regarding WhatsApp use to facilitate both English language teaching and promote out-of-class learning. The participants confirmed the user-friendly and practical aspects of the application which facilitates both teaching and learning processes. The practical implications of these findings are to support teachers in their agentive role and allow for the bottom-up mobile technology-reliant initiatives that support achieving educational results.
Phenotypic Screening of F4 Breeding Lines against Bacterial Blight Disease in Rice
Authors: Alekya K. , Prasanna B. Laxmi , Balram M. , Balram N. , Nayak P. Gonya , Srinivas B. , Madhukar P.
Published: January 2022

Biotic stresses are major threat to rice production. Among biotic stresses, bacterial leaf blight is one of the major diseases affecting rice grain production in rice growing areas. Present investigation was conducted to evaluate phenotypic effect of 50 breeding lines from a cross (Pranahitha//ISM/MTU1010) in glass house at Regional Agricultural Research Station, Jagtial by inoculating Bacterial leaf blight culture (DX-020) by leaf clipping method. Out of these 50 F4 lines evaluated, twenty nine breeding lines showed resistant reaction with disease score of 1. Eleven lines showed moderately resistant reaction with disease score 3. Twenty nine breeding lines that were resistant with disease score 1, had excellent grain yield. Hence, these lines can be advanced to further generations. Thus the present study has demonstrated that phenotypic selection is successful in the glass house and these breeding lines with higher yield levels are expected to perform better in the field trials and further in the farmers fields with the good level of bacterial blight resistance.