bluuebunny/crossref_metadata_2025 huggingface dataset:
Perlindungan Hukum Notaris Pengganti Dalam Pemeriksaan Sebagai Saksi Di Pengadilan Berdasarkan Rahasia Jabatan Notaris
Authors: Puspitasari Amelia Meynanda , Efendi Aan
Published: January 2023

Pasal 66 ayat (1) Undang-Undang Nomor 30 Tahun 2004 tentang Jabatan Notaris sebagaimana diubah dengan Undang-Undang Nomor 2 Tahun 2014 tentang Perubahan atas Undang-Undang Nomor 30 Tahun 2004 tentang Jabatan Notaris merupakan suatu perlindungan hukum bagi Notaris, yakni adanya Lembaga Majelis Kehormatan Notaris sebagai lembaga perlindungan hukum bagi Notaris. Majelis Kehormatan Notaris berperan dalam memberikan perlindungan profesi Notaris berkaitan dengan kerahasian akta yang dibuat oleh Notaris. Perlindungan hukum yang dimaksud pasal tersebut adalah ketika seorang Notaris akan dipanggil untuk memenuhi panggilan persidangan, diperlukan persetujuan ataupun penolakan Majelis Kehormatan Notaris terlebih dahulu. Selain itu Majelis Kehormatan Notaris juga berwenang untuk memberi persetujuan pengambilan salinan akta maupun berkas terkait protokol Notaris ke pengadilan. Notaris maupun Notaris Pengganti memiliki kewajiban menjaga kerahasiaan akta yang dibuatnya serta memenuhi panggilan penyidik dan memberi keterangan yang sebenar-benarnya untuk membantu penyidik dalam menyelesaikan perkara. Namun, Pasal 66 ayat (1) UUJN hanya menyebutkan bahwa Notaris saja yang diberi persetujuan oleh Majelis Kehormatan Notaris dan tidak menyebutkan demikian bagi Notaris Pengganti. Oleh karena itu, Pasal 66 ayat (1) UUJN tidak berlaku bagi Notaris Pengganti, sehingga perlindungan hukum bagi Notaris Pengganti dalam UUJN masih belum diatur dengan jelas. Permasalahan lain yaitu terdapat dalam Pasal 36 tentang honorarium dan Pasal 52 tentang larangan yang hanya diperuntukkan kepada Notaris sehingga Notaris Pengganti tidak mendapatkan hak yang sama seperti Notaris dalam menjalankan jabatannya.
A Social History of the Ideas of the Paris Commune
Authors: Knapowski Stanisław
Published: January 2023

Review of the book Commun-Commune: penser la Commune de Paris (1871), published on the 150th anniversary of the Paris Commune. The author of the publication aims to reconstruct the entire spectrum of political ideas circulating in “Free Paris” in the spring of 1871. The analysis is carried out from the perspective of the political practices and participants of events. The content of the studied ideas is considered only through the methods of their use and the consequences which influenced history. In the review this is interpreted as a manifestation of thinking close to the theoretical concept of the “social history of ideas”. Another important aspect of the reviewed book is the reflections on the politics of memory and legends, i.e. a mythologized approach to the past understood as a source of cognitive errors that hinder the proper understanding of events.
Parcel Locker Applications in Turkey
Authors: AKDOĞAN Kutay , ÖZCEYLAN Eren
Published: January 2023

Alternative delivery applications are gaining popularity today, and parcel lockers are differentiated from others as they offer different delivery location options to customers. One of the biggest problems faced by courier companies today is that customers are not always available at the place of delivery during delivery. This leads to an increase in failed deliveries that place an extra burden on last mile operations, not only in terms of cost, but also in terms of environmental concerns. One of the effective methods to deal with this problem is parcel lockers. Parcel lockers and related concepts are currently used in various countries worldwide, and in some countries, their installation and use are supported by the government. Parcel lockers not only help logistics companies navigate their operations and costs, but also give the customer the power of choice. Therefore, it is considered necessary to investigate the parcel locker applications in Turkey. This paper intends to present the current state of parcel lockers in Turkey, the companies providing the service, their profiles, and their plans to provide beneficial knowledge to academia and industry.
TRANSPORT FEATURES OF A NEW, SELF-ATTUNED CONVEYOR
Authors: CZUBAK Piotr , SURÓWKA Witold
Published: January 2023

The new vibratory conveyor destined for the accurate dosing of materials was investigated in the present work. The possibilities of the system to transport materials in the circum-resonant zone were tested analytically, as well as by simulations. The optimal work point of the system, which allowed a decrease in the amplitude of eliminator vibrations on its suspension due to operations on the resonance slope, was determined. Transport velocities depending on the excitation frequency and feed mass were determined by simulations. The results were verified on the conveyor of industrial dimensions designed and built in accordance with the patent application.
AUTONOMY OF URBAN LIGHT RAIL TRANSPORT SYSTEMS AND ITS INFLUENCE ON USERS, EXPENDITURES, AND OPERATIONAL COSTS
Authors: KOSTRZEWSKI Mariusz , ELIWA Ahmed , DAWOOD Ahmed
Published: January 2023

The aim of this paper is to study and highlight various effects of automizing urban light rail transport systems by examining the impact of such structures on common users, as well as the expenditures and operational costs involved. By providing an overview of different transportation networks through the three categories of expenditure—transportation, maintenance, and administration—an idea of the general operational cost can be established. Additionally, by indicating the aforementioned cost, the effect of the grade of automation on costs can be determined and explained. However, this paper does not include an attempt to estimate these costs; it only states what may affect such costs. Furthermore, the factor of safety is considered by underlining the changes expected to occur with the implementation of such networks. The implementation of autonomous rail systems would result in lower operational costs, which is discussed in this paper based on another study. At the same time, the factor of safety was also observed as simultaneously increasing, as were the overall experiences of users, both in terms of aesthetics and function. The only setback found by the research is that some users would be reluctant to use a network without an operator.
Peningkatan Kompetensi Siswa SMK Muhammadiyah 4 Surakarta mengenai Industri Baterai Lithium Ion
Authors: Paramitha Tika , Dyartanti Endah Retno , Jumari Arif , Purwanto Agus , Nur Adrian , Budiman Anatta Wahyu
Published: January 2023

Sekolah Menengah Kejuruan (SMK) Muhammadiyah 4 Surakarta memiliki jurusan Kimia Industri yang mempersiapkan tenaga terampil di industri kimia untuk mendukung dalam pengembangan teknologi. Salah satu Industri Kimia yang berkembang saat ini adalah Industri Baterai Lithium Ion (LIB). LIB saat ini digunakan tidak hanya pada perangkat elektronik portabel, seperti komputer dan telepon seluler, tetapi juga untuk kendaraan listrik atau kendaraan hybrid. Oleh karena itu, lulusan SMK dengan Program Keahlian Kimia Industri hendaknya menyiapkan lulusan yang mempunyai kompetensi di bidang teknologi baterai. Dengan kompetensi dosen dalam teknologi produksi material aktif baterai pada skala mini plant dan fasilitas yang mewadai di Pusat Unggulan IPTEK (PUI) PT Teknologi Penyimpanan Energi Listrik, maka sangat memungkinkan dosen untuk mengenalkannya kepada siswa SMK Muhammadiyah 4 Surakarta. Metode yang dilakukan dalam pelatihan ini adalah metode ceramah, diskusi dan praktik. Adapun materi yang disampaikan mengenai baterai lithium ion (aplikasi, jenis, tipe, struktur, proses pembuatan material aktif, dan fabrikasi). Kegiatan praktik yang dilakukan yaitu praktik pembuatan material aktif katoda dengan metode ko-presipitasi dan fabrikasi sel baterai. Hasil kegiatan ini adalah kompetensi siswa dan guru meningkat yang ditunjukkan dengan nilai Pre-Test yang lebih baik dibandingkan dengan Post-Test.
Hospital information system and quality control of treatment
Authors:   “Interin Technologies” Inc., Gladkov N. V. , Fokht O. A. ,   Ailamazyan Program Systems Institute of RAS
Published: January 2023

The article presents an approach to quality control of treatment at the present stage. A trend of today – the use of a medical information system for quality control of the medical and diagnostic process (with special attention paid not to reporting to higher authorities, but to the organization of internal control in a medical organization). Possible tools and benefits are considered. P u r p o s e . Determining the capabilities of Hospital Information System for quality control of medical care. M a t e r i a l s a n d m e t h o d s . We analyzed the requirements of regulatory acts for the control of medical care, as well as the real needs of HIS users. An experiment on the formation of a set of tools for quality control of treatment was carried out using the example of Hospital Information System Interin PROMIS Alpha. We considered the prospects taking into account the results of the research of Ailamazyan Program Systems Institute of RAS in the field of working with clinical data banks. R e s u l t s . General requirements for internal quality control include 5 levels of control. The use of HIS is most in demand in the following areas: compliance with medical care standards, internal control tools (analysis of compliance with clinical recommendations, expert assessment of the quality of treatment, quality and safety of medical activities, format and logic control, etc.) and ensuring patient safety. The use cases of the HIS in these areas are illustrated by the example of the Hospital Information System Interin PROMIS Alpha. The prospects of the development of the direction consisting in transferring the main load from a person to an HIS and in attracting AI technologies and neural networks are considered. F i n d i n g s . The main problems of quality control are the need for the participation of highly qualified specialists and the high complexity of the process. These problems can be solved by shifting the control regulations from «after the fact» to «proactive» and «in real time» by using HIS, as well as involving knowledge-intensive technologies in this process with the involvement of artificial intelligence and neural networks
Identifikasi Usaha Pengolahan Kelapa di Kecamatan Lasalimu Kabupaten Buton
Authors: Herdhiansyah Dhian , Safitri Dian , Rianda La , Nln Asriani
Published: January 2023

Penelitian ini bertujuan untuk mengetahui bentuk dan jenis serta kapasitas usaha pengolahan kelapa di Kecamatan Lasalimu, Kabupaten Buton. Penelitian ini telah dilaksanakan di Kecamatan Lasalimu, Kabupaten Buton. Penentuan lokasi penelitian dilakukan secara sengaja (purposive) dengan responden berjumlah 56 orang yang di klasifikasi dalam 3 kategori yaitu usaha pengolahan kelapa dengan memiliki kebun sebanyak 28 responden, usaha kelapa tanpa pengolahan sebanyak 26 responden dan usaha pengolahan kelapa tanpa memiliki kebun sebanyak 2 responden. Pengumpulan data dilakukan dengan metode kuesioner dan metode wawancara. Analisis yang digunakan adalah analisis deskriptif. Hasil penelitian menunjukan bahwa bentuk usaha pengolahan kelapa di kecamatan lasalimu adalah usaha mikro dan jenis usahanya adalah usaha kopra, usaha kelapa tanpa pengolahan dan usaha arang. Dari ketiga jenis tersebut usaha yang menguntungkan merupakan usaha kopra dengan kapasitas usaha sebesar 1.707 kg per tahunnya dengan rata-rata jumlah tenaga kerja sebanyak 3 orang serta usaha arang dengan pendapatan rata-rata sebesar 12.750 kg dengan memiliki tenaga kerja sebanyak 12 orang, dan usaha yang dijalankan masih berjalan sampai saat ini.
Pengaruh Kemasan Polypropilen terhadap Mutu Air Kelapa Genjah Sebagai Fresh Beverage Drink Selama Penyimpanan
Authors: Pradhana Adhitya Yudha , Barlina Rindengan , Trivana Linda , Takaheghesan Nikson
Published: January 2023

ABSTRAK

Buah kelapa mempunyai potensi untuk dijadikan produk minuman segar maupun isotonik. Tujuan dari penelitian ini mengetahui mutu air kelapa pada berbagai tingkat kematangan dan pengaruh penyimpanan terhadap mutunya sebagai minuman segar dalam kemasan berdasarkan SNI 01-4268-1996 dan sebagai minuman isotonik berdasarkan SNI 01-4452-1998. Penelitian berbentuk faktorial, Rancangan Acak Lengkap (RAL) dengan 3 ulangan. Penelitian tahap satu yaitu pengamatan mutu umur panen kelapa (7, 8, 9, 10, dan 11 Bulan). Hasil mutu terbaik kemudian dikemas polypropilen dengan berbagai suhu penyimpanan, yaitu suhu ruang (±28°C), -2°C dan 10°C. Data dianalisis menggunakan ANOVA dengan α=5%. Hasil yang diperoleh adalah kelapa muda umur panen 8 Bulan layak untuk dijadikan minuman segar karena mengandung masing-masing TPT 5,18 %Brix dan pH 5,20, yang sesuai dengan SNI 01-4452-1998 sebagai Minuman Isotonik. Umur simpan yang lebih lama terdapat pada suhu -2ºC yaitu 8 hari dengan nilai TPT 5,20 %Brix, pH 4,93, dan nilai sensori terhadap rasa dan aroma masing-masing 3,05 dan 3,15 yaitu agak suka. Sampel pada suhu penyimpanan 10ºC diterima panelis hanya sampai 6 hari penyimpanan. Air Kelapa dalam kemasan polypropilen yang disimpan pada suhu -2ºC dan 10 ºC memenuhi SNI 01-4268-1996 sebagai minuman segar dalam kemasan sampai penyimpanan hari ke-2 dengan nilai pH sebesar 5,52 dan 5,37 serta TPT sebesar 5,50 %Brix. Sedangkan sampel dengan suhu penyimpanan -2ºC memenuhi syarat SNI 01-4452-1998 sebagai minuman isotonik sesuai syarat total padatan terlarut, aroma, warna, dan rasa sampai hari ke-8 penyimpanan.
Plan de negocio para la elaboración y comercialización de aromatizantes naturales en Lima Metropolitana
Authors:   , Granada Lopez Amiel , Malpartida Meza Delia , Santos Quispe Deyli , Villavicencio Cueva Yannely Berliz
Published: January 2023

El presente trabajo es un estudio para evaluar la viabilidad del negocio analizando diferentes aspectos incluyendo el análisis económico y financiero. Se eligió como nombre del proyecto Fragancias del Campo S.A.C., que estará dedicada a la producción y comercialización de aromatizantes naturales. En la actualidad los aromatizantes que existen en el mercado tienen costos más elevados y la mayoría de ellos contienen químicos dañinos para la salud y el ambiente. Por ello se pretende atender al público del nivel socioeconómico (NSE) B y C, ofreciendo productos elaborados con insumos naturales y de calidad a precios accesibles. Se ingresará al mercado con un precio de venta promedio de S/ 33.93 soles, proyectando un ingreso de S/ 15,000.00 soles mensuales, con el incremento de sus ventas en 2% mensuales. Para llegar al público objetivo se utilizará las redes sociales y la página web, realizando publicaciones interdiarias destacando los beneficios de los aromatizantes. Para la distribución de los productos se tercerizará con la finalidad de reducir costos. El proyecto en su totalidad será financiado directamente por los socios, se espera poder llegar a las cuotas de ventas mensuales y así buscar el financiamiento a futuro e ir creciendo año tras año, logrando los objetivos planteados a corto, mediano y largo plazo.
Asociación entre discordancia intraoperatoria e histopatológica y resultados posoperatorios en pacientes intervenidos a apendicectomía abierta. Hospital San José del Callao, año 2019
Authors:   , Reluz Fernández de Córdov Mario Guillermo
Published: January 2023

Objetivo: Determinar la asociación entre la discordancia intraoperatoria-histopatológica y resultados posoperatorios en pacientes intervenidos a apendicectomía abierta. Hospital San José del Callao, 2019. Materiales y métodos: Investigación observacional, analítico-relacional, retrospectivo y cuantitativo. La muestra fue conformada por 154 pacientes. El análisis estadístico se realizó en el programa SPSS 25. Se realizó la prueba U de Mann Whitney. Resultados: La edad promedio de los pacientes fue 31.3 ± 11.1 años, el 65.6% fueron mujeres y el 20.8% presentó comorbilidades (principalmente asma, gastritis y obesidad). El 65.9% de los pacientes presentó Discordancia entre el diagnóstico intraoperatorio y el diagnóstico histopatológico. No se encontró relación significativa entre la discordancia intraoperatorio-histopatológica con las complicaciones posoperatorias (solo se observaron complicaciones en el 6.5% de los pacientes con discordancia, ninguno en los pacientes sin discordancia), estancia hospitalaria (2.3 ± 1.1 vs 2.1 ± 0.6 días, con y sin discordancia, respectivamente, p=0.780), ni reingreso hospitalario (solo se observó un caso de reingreso hospitalario en un paciente con discordancia, ninguno en los pacientes sin discordancia). Conclusión: Se identificó que el 69.5% de los casos si existe discordancia. No se encontró asociación significativa entre la discordancia intraoperatoria-histopatológica y resultados posoperatorios en pacientes intervenidos a apendicectomía abierta. Hospital San José del Callao, 2019.
Determinación de aflatoxina M1 en leche fresca de vaca procedente de establos de crianza intensiva del distrito de Lurín, región Lima
Authors:   , Otero Chafalote Milú Larushka
Published: January 2023

El presente trabajo tiene como objetivo determinar la presencia de aflatoxina M1 en leche fresca de vaca procedente de los establos del distrito de Lurín. Con este fin se analizaron 39 muestras de leche, obtenidas directamente del tanque de enfriamiento del ordeño de la mañana de 13 establos durante tres días de manera interdiaria. Cada muestra de 100 ml fue colocada y sellada en envases estériles de plástico y almacenadas a 4°C para ser trasladadas al Laboratorio de Microbiología de la Universidad Científica del Sur en donde se analizaron. La detección y cuantificación se realizó por medio del test de Elisa Bio-Shield M1 ES que cuenta con un rango de cuantificación de 0.005-0.25 µg/l o ppb, un lector de placas con filtro de 450 nm y el software Prognosis Data Reader. Los resultados se evaluaron mediante estadística descriptiva. Se halló la presencia de aflatoxina M1 en el 48.7% (19/39) de las muestras con valores que fluctúan entre 0.002-0.043 µg/l y en el 84.6% (11/13) de los establos, estando el 100% de estos resultados dentro de los límites permitidos para leche fresca según el Codex Alimentarius (0.5 µg/l).
Controles de ejecución asociados a la gestión de proyectos de las empresas contratistas constructoras de una minera importante ubicada en Cajamarca - Perú
Authors:   , Bringas Arana Alcides Omar
Published: January 2023

La investigación que se presenta a continuación tiene como finalidad determinar la relación entre los controles de ejecución en la gestión de proyectos y los rasgos distintivos de las empresas contratistas constructoras de una minera importante ubicada en Cajamarca - Perú. El proyecto se realizó con base en un diseño no experimental con un enfoque mixto, la muestra es de tipo no probabilística y está constituida por 33 empresas. Para la recolección de datos se aplicaron encuestas a los gerentes y/o ingenieros de control de proyectos de las empresas contratistas constructoras y también se realizaron entrevistas a especialistas; para determinar la relación entre las variables se empleó el programa estadístico SPSS versión 24.0 sustentado en la estadística descriptiva de la prueba de Chi cuadrado. Entre los resultados se destaca que existe una relación significativamente estadística entre los controles de ejecución de proyectos y las características de las empresas contratistas constructora con un valor de p< 0,05, lo que implica que las empresas más grandes (con un mayor número de empleados y con un tiempo de operación de 21 años) aplican controles de tiempo, calidad y costos en sus proyectos en comparación con las empresas pequeñas. De igual forma se observó que las organizaciones que implementan los controles presentan un bajo nivel de incumplimiento en sus proyectos en términos de calidad, tiempo y costos.
Percepción estética de los ortodoncistas, dentistas y laicos sobre la curvatura del labio superior en la sonrisa gingival
Authors:   , Valverde Montalva Sergio Hernán
Published: January 2023

Introducción: A pesar que existe un consenso relativo sobre la forma de tratamiento de la sonrisa gingival según la etiología, aún sigue existiendo variabilidad en la literatura al momento de calificar una sonrisa gingival como estética o anti estética. Son las características combinadas las que determinan si una sonrisa es o no agradable. El propósito de esta investigación fue combinar la morfología del labio superior a diferentes niveles de exposición gingival y determinar su influencia en la apreciación de una sonrisa gingival. Métodos: Se alteró digitalmente una fotografía para combinar 3 tipos de labio superior (ascendente, recto y descendente) con 5 niveles de exposición gingival (0mm, 1mm, 3mm, 4mm y 5mm) dando como resultado 15 imágenes que serían calificadas en una EVA por 3 grupos de evaluadores (dentistas, ortodoncistas y laicos) haciendo un total de 150 evaluadores. Resultados: La curvatura labial descendente tuvo un efecto negativo en la evaluación estética de la sonrisa en las exposiciones gingivales más altas de 3mm, 4mm y 5mm para todos los grupos de evaluadores (aproximadamente 20-30 puntos menos que las formas de curvatura ascendente y recta, P<0.05). El grupo de individuos laicos calificó con puntaje más alto (aproximadamente 10 puntos más) al evaluar la morfología labial ascendente con exposición gingival de 5mm (P=0.029). Conclusiones: Los ortodoncistas deben considerar que las formas de curvatura del labio superior ascendentes o rectas pueden tener un impacto positivo en la estética de la sonrisa percibida, mientras que la morfología descendente tendrá un efecto negativo al evaluar diferentes grados de sonrisa gingival.
Differential response of growth and C:N:P stoichiometry to Si supply between bamboo and tree saplings
Authors: Liu Xiaoyu , Tang Xinghao , Compson Zacchaeus G. , Huang Dongmei , Zou Guiwu , Luan Fenggang , Song Qingni , Fang Xiong , Yang Qingpei , Liu Jun
Published: January 2023

Background
Silicon (Si), while not an essential element for plant growth, can be important for high Si-accumulating Poaceae, such as Moso bamboo. However, other trees do not actively take up dissolved silicic acid [Si(OH)4] from the soil, likely because they have fewer or no specific Si transporters in their roots. It is unclear what causes the different growth and nutrient status between bamboo and other trees under varying Si supply.
Results
In this study, we found that Si addition increased the biomass production of P. pubescens saplings, likely by improving its net photosynthetic rate and nutrient status, which contrasted to the saplings of P. bournei and S. superba. In addition, we found that C concentrations of aboveground tissues in P. pubescens declined with increasing Si supply, likely due to a partial substitution of organic C compounds by Si. Si addition increased the foliar C:N stoichiometry in the saplings of P. bournei and S. superba through altering their concentration of C and N, but did not affect the C:N or N:P stoichiometry of C. lanceolata and P. pubescens.
Conclusions
Si elicited either a positive or negative effect on plants, such as improve or weaken photosynthetic capacity, increase or decrease the concentration of C and N in plants, depending much on plant species and the Si supply level of in the environment. These results have implications for assessing the growth and nutrient status between bamboo and trees (i.e, high Si-accumulating plants compared to other plants) when Si availability is altered in ecosystems.
Factors associated with dosimetric changes and value of adaptive radiotherapy in patients undergoing radiotherapy for head and neck cancer
Authors: Bonnet Flore , Créhange Gilles , Berthaut Aurélie , Fouquier Anais , Truc Gilles , Chevalier Cédric , Roukoz Camille , Mirjolet Céline , Bidault Fabienne , Vulquin Noémie , Thibouw David
Published: January 2023

Background: Anatomical changes may occur during radiotherapy (RT) in Head and neck (H&N) cancer patients. These may lead to deviations between the initially planned doses and the delivered doses leading to a risk of organs at risk (OAR) overdose and tumor volume undercoverage. The aim of this study is to identify H&N patients who would benefit from adaptive radiotherapy (ART).
Material and Methods: Retrospective data were collected for patients treated with RT for H&N cancer requiring a new dosimetric computed tomography (CT) during treatment. The initially planned doses to OAR and tumor volumes were compared to the doses actually received with and without ART. Predictive criteria for dose deviations greater than 5% were tested.
Results: Among 51 patients included in this study, 29 had an overdose to at least one OAR and 13 had a tumor volume undercoverage. Brainstem overdose was associated with cervical volume decrease between the initial dosimetric CT and the 36±2Gy cone beam CT (CBCT) (OR= 11.29, p= 0.027). Homolateral parotid gland (PG) overdose was associated with a decrease of cervical volume (OR= 4.5, p= 0.033) as well as the decrease in high-risk clinical and planned target volumes (HR CTV and PTV) between the initial and the new dosimetric CT [(OR= 3.38, p = 0.04) and (OR= 7.5, p= 0.017 respectively)]. Tumor volume undercoverage was associated with an older age at diagnosis (OR= 6.79, p= 0.022), a small initial macroscopic tumor volume (OR= 9.33, p= 0.006), and a decrease in HR CTV and PTV at the new dosimetric CT (OR= 7.29, p= 0.016; and OR= 7.7, p= 0.006 respectively). With ART, 19 patients (37.3%) showed an improvement in the sparing of at least one OAR and 6 (11.8%) an improvement in tumor volume coverage.
Conclusion: Factors such as a decrease in cervical diameters and volume during RT, low initial GTV, high age at diagnosis or a decrease in CTV and PTV HR during RT may help predict possible overdosage to OARs or PTV undercoverage. This might allow a better selection of patients who can benefit from ART.
Accuracy of Invisalign Progress Assessment with clear aligners: a retrospective study
Authors: Li Bo , Xu Yi-Meng , Shi Rui-Ying , Hu Yi-Rong , Liu Si-Ying , Gu Ze-Xu
Published: January 2023

Objective
The objective of this study was to detective the accuracy of model superimposition and automatic analysis for upper and lower dentition width in Invisalign Progress Assessment during the process of clear aligners.
Methods
19 cases were included in this study. Pre-treatment dental cast(T0) and post-treatment dental cast after staged treatment(T1) were available for three-dimensional model superimposition. Subsequently, movements of maxillary teeth in horizontal plane (cross section) after staged treatment, width of upper and lower dentition were measured by three-dimensional model superimposition in real world and Invisalign Progress Assessment separately. Consequently, the data collected from these two methods was compared.
Results
In Invisalign Progress Assessment, movements of maxillary teeth in horizontal plane after staged treatment was 2.31（1.59,3.22） (median (upper quartile, lower quartile)) millimeter (mm), while in three-dimensional model superimposition, the result was 1.79（1.21,3.03）mm. The difference between two groups is significant(P＜0.05). Intercanine width upper, intermolar width upper, intercanine width lower, and intermolar width lower were 36.55±2.76mm, 56.98±2.62mm, 28.16±1.85mm, 53.21±2.72mm separately in Invisalign Progress Assessment and were 36.48±2.78mm, 56.89±2.58mm, 28.05±1.85mm, 53.16±2.64mm separately in three-dimensional model analysis, which were no significant difference among these groups (P＞0.05).
Conclusions
The data from Invisalign Progress Assessment was not in parallel with what achieved from model superimposition with palate as reference completely. The accuracy of model superimposition in Invisalign Progress Assessment needs further investigation, whereas the accuracy of model analysis in Invisalign Progress Assessment was accurate. Thereby, results from Invisalign Progress Assessment should be interpreted with caution by the orthodontist in clinic.
Is it safe to perform Enterectomy in colorectal cancer patients aged 80 or older? A meta-analysis and a systematic review
Authors: Chen Bangquan , Yu W. H. , Ma Y. , Xu P. R. , Qing Y. , Shanu Shantanu , Sun Q.N. , Ren J. , Wang D.R.
Published: January 2023

Background
Colorectal cancer is one of the four most common cancers in the world. At present, Human beings have stepped into an aging society, and the number of over eighties colorectal cancer patients has increased year by year. However, few high-quality studies focused on the post-operation complications and long term outcomes of octogenarian patients with colorectal cancer. This meta-analysis based on published studies aims to assess the safety of treating octogenarian CRC patients with surgery.
Methods
Databases, including PubMed, Embase, and Cochrane Library were searched until July 2022. The incidence of preoperative comorbidities, postoperative complications, and mortality was assessed using odds ratios (ORs) with corresponding 95% confidence intervals (CIs). Furthermore, the hazard ratios (HRs) with 95% CIs were applied for survival outcomes.
Results
A total of 13,790 patients with CRC in 21 studies were included. Our results demonstrated that octogenarian patients were associated with a higher burden of comorbidities (OR = 3.03;95% CI: 2.03, 4.53༛P = .000), high incidences of overall postoperative complications (OR = 1.63༛95% CI༚1.29,2.06༛P = .000), high internal medicine postoperative complications (OR = 2.38༛95% CI༚1.76, 3.21༛P = .000), high in-hospital mortality (OR = 4.01༛95% CI༚3.06, 5.27༛P = .000) and poor overall survival (OR = 2.13༛95% CI༚1.78, 2.55༛P = .000).But there is no statistical difference in surgery-related postoperative complications(OR = 1.16༛95% CI༚0.94, 1.43༛P = .16) and DFS༈OR = 1.03༛95% CI༚0.83, 1.29༛P = .775).
Conclusions
Considering the high burden of comorbidities, high incidences of postoperative complications and mortality, surgery for extremely elderly patients with CRC requires deliberation. Nevertheless, the survival outcomes of octogenarian and even older patients is similar to those of youth patients. Some of them might benefit from conservative treatments or palliative surgeries indeed. Hereby, individualized treatment is recommended for such patients. Instead of actual age, physical age is the real element the clinicians should take into consideration.
Extraction, purification, characterization, and α-amylase inhibition of C- Phycocyanin from Dolichospermum spiroides
Authors: Sanniyasi Elumalai , Jayachandran Sharath , Gopal Rajesh Kanna , Rajesh Damodharan
Published: January 2023

Phycocyanin is a phycobiliprotein pigment synthesized by cyanobacteria to protect the light-harvesting complex from the high intensity of light during photosynthesis. Intriguingly, it has a wide range of biotechnological applications such as pharmaceuticals, cosmeceuticals, and food-grade pigments based on their purity. Phycocyanin is a highly antioxidant water-soluble pigment with anticancer, anti-inflammatory, hepatoprotective, and neuroprotective properties. Phycocyanin from Spirulina (Arthrospira platensis) has been reported to possess antidiabetic activity by inhibiting the α-amylase enzyme both in vitro and in vivo. In our present study, C-phycocyanin was extracted and purified from the cyanobacterium Dolichospermum spiroides with a purity of 1.2, and 3.5 after column chromatographic purification with a molecular weight of 16 kDa. Based on protein mass fingerprinting, it has about 45% amino acid sequence similarity with the C-PC of Aphanizomenon flos-aquae. The C-PC of D. spiroides has a maximum inhibition of 90% at 250 µg/mL of α-amylase enzyme. At the same concentration of the standard drug acarbose, which attained only 80% of α-amylase inhibition. As a result, the IC50 value of C-PC from D. spiroides was 162.16 ± 0.63 µg/mL, and acarbose was 205.86 ± 0.53 µg/mL. Therefore, the alpha-amylase inhibition of phycocyanin was higher than that of the standard drug acarbose. Hence, it is clear that the C-PC of D. spiroides has anti-diabetic activity.
A Miller Fisher syndrome mimicking Lambert-Eaton syndrome: Case Report
Authors: Abbes Amal , Mhiri Mariem , Dhia Rihab Ben , Saad Yasmine , Frih-Ayed Mahbouba
Published: January 2023

Background :
Miller Fischer Syndrome (MFS) is a variant of Guillain barre syndrome. It is characterized by the triad of ophtalmoparesis, ataxia and areflexia. We describe in this paper an atypical case of a patient with MFS with positivity of glutamic acid decarboxylase (GAD) antibodies.
Case presentation :
A 35-year-old male was admitted to our neurology department with binocular diplopia, headache, and gait ataxia for 3days. Physical examination was remarkable for ophtalmoplegia, cerebellar ataxia and areflexia. MRI brain was normal. Also, cerebrospinal fluid analysis and electromyography within the first week were normal. Exaustif serelogical workup revealed negative anti-GQ1b antibody, but significant increase of GAD- antibody. Evolution was marked by the appearance of a facial diplegia. Neurophysiological studies showed evidence of sensoriel neuropathy of upper and lower limbs. Cerebrospinal fluid (CSF) analysis showed elevated protein. A maximal increment was revealed at twenty Hz repetitive nerve stimulation. Clinical diagnosis of atypical MFS was made. The patient was received a course of Immunoglobulines with completly recovery.
Conclusion : Our finding suggest that GAD-antibodies (GAD-Ab) may play a role in presynaptic neuromuscular transmission defect. It is responsible on an atypical painting by miller fischer mimicking an Lambert Eaton syndrome.
Spatial network structure characteristics and influencing factors of haze in Europe based on weighted network approach
Authors: Lu Ping , Li Zhihong , Wen Ying , Niu Ruiyu , Zhang Jiayi , Wang Yiran , Han Liangliang
Published: January 2023

Haze pollution in Europe has always been one of the topics of concern. It is very rare to investigate the haze transport and its influencing factors among European countries from the perspective of complex network. Different from binary networks, this paper constructs a weighted and directed network of European haze based on the data of European countries from 2010 to 2019. Based on the European haze network, the structural characteristics of the haze network are investigated, the path, direction and strength of haze transfer are identified, and the influencing factors of the haze network are explored. It is found that the spatial association network of haze in Europe presents a complex network structure and shows the features of small-world. The haze network in Europe shows a typical “core-periphery” structure. Germany, France, UK, Netherlands and Italy are at the center of the network. The results of block model analysis show that Luxembourg, Cyprus, Lithuania, Ireland, Switzerland, Slovenia, Latvia, Portugal, Denmark, Estonia, Malta and Iceland play the role of “net receiver” in the European haze network; Belgium, Czech, Netherlands, Austria, Slovakia, Hungary, Finland and Norway play the role of “two-way spillover” in the haze network; Romania, Sweden, Greece, Bulgaria, Croatia and Spain play the role of “agent” in the haze network; Germany, France, Italy, Turkey, UK and Poland play the role of “net spillover” in the haze network. The results of QAP analysis show that the differences in industrial structure, environmental regulation intensity, energy consumption, science and technology level, automobile exhaust emissions and vegetation density play a significant role in promoting the formation of the haze network in Europe. Based on the perspective of complex networks, this paper provides policy suggestions for cross-border collaborative governance of haze in Europe.
Relationships between fatigue differential experience and anxiety, depression, and serum hormones among Chinese cancer survivors: a cross-sectional study
Authors: Gu Shanshan , Xu Yun , Zhu Xiaoshu , Lam Anderson , Gong Lutian , Wang Jinghui , Guo Xinyu , Fu Li , Shi Jiyan , Liu Ketan , Yi Danhui , Wang Feiye
Published: January 2023

Previous research has demonstrated that different cancer survivors with the same disease history or treatment may have different experiences of fatigue. This cross-sectional study aims to explore how demographic, oncological, sociological, psychological, and serum hormone levels interact to influence the distinct experiences of fatigue (Cancer-related fatigue occurrence and fatigue degree). General information, fatigue, psychological factors was evaluated by general information questionnaire, the Revised Piper's Fatigue Scale-Chinese Version, and the self-report Hospital Anxiety and Depression Scale. Serum hormones were measured with chemiluminescent enzyme immunoassay (Zhengzhou Antobio). 306 patients were included, 229 (74.8%) were diagnosed with CRF, including 94 (41.0%) with mild fatigue, 121 (52.8%) with moderate fatigue, and 14 (6.1%) with severe fatigue. Multivariate regression analysis showed that higher depression scores, aldosterone levels may increase the risk of CRF. Patients who are obese (BMI ≥ 28 kg/m2) may help to reduce the risk of CRF. Other contributing factors for increased levels of fatigue (p < 0.05) include being female, having anxiety, depression and high aldosterone levels. The research suggested that CRF was a common symptom in cancer survivors and pay attention to these influencing factors may help to better identify patients susceptible to fatigue and provide long-term, targeted interventions.
Evaluation of Accessibility and Equity to Hospitals by Public Transport: Evidence from Six Largest Cities of Ohio
Authors: Alam Md Saiful , Tabassum Nusrat Jahan , Tokey Ahmad Ilderim
Published: January 2023

Introduction: In the United States, health care has long been viewed as a 'right,' and residents of Ohio are no exception. The Ohio Department of Health ensures that this right exists for all residents of Ohio. Socio-spatial characteristics, however, can have an impact on access to health care, particularly among vulnerable groups. This article seeks to measure the spatial accessibility to healthcare services by public transport in the six largest cities of Ohio based on population and to compare the accessibility of healthcare to vulnerable demographic groups. To the authors' knowledge, this is the first study to analyze the accessibility and equity of hospitals by public transit across different cities in Ohio, allowing the identification of common patterns, difficulties, and knowledge gaps.
Methodology: Using a two-step floating catchment area technique, the spatial accessibility to general medical and surgical hospitals through public transportation was estimated, considering both service-to-population ratios and travel time to these health services. The average accessibility of all census tracts and the average accessibility of the 20% of most susceptible census tracts were determined for each metropolitan region. Using Spearman's rank correlation coefficient between accessibility and vulnerability, an indicator was then devised to evaluate vertical equity.
Findings: Within cities (except Cleveland), people of vulnerable census tracts have less access to hospitals via public transportation. These cities (Columbus, Cincinnati, Toledo, Akron, and Dayton) fail in terms of vertical equity and average accessibility. According to this, vulnerable census tracts in these cities have the lowest accessibility levels.
Conclusion: This study emphasizes the issues connected with the suburbanization of poverty in Ohio's large cities and the need to provide adequate public transportation to reach hospitals on the periphery. In addition, this study shed light on the need for additional empirical research to inform the implementation of guidelines for healthcare accessibility in Ohio. Researchers, planners, and policymakers who want to make healthcare more accessible for everyone should take note of the findings in this study.
Investigation of Mexiletine Hydrochloride Binding on Transition Metal Oxide Nanoparticles by Capillary Electrophoresis
Authors: Elmorsi Eman T. , Lai Edward P.C.
Published: January 2023

The binding affinity of pharmaceutical salts to metal oxide nanoparticles is a fundamental environmental process that determines their transport and bioavailability. Mexiletine hydrochloride (MEX.HCl) interactions with different transition metal oxide nanoparticles (TMONPs) in aqueous dispersion were evaluated by capillary electrophoresis to determine their binding affinities. The results indicated that MEX.HCl bound onto TiO2, Co3O4 and ZnO nanoparticles in alkaline, neutral and acidic pH levels. Interestingly, TiO2 manifested the highest binding affinity of 81 ± 1% at pH 9.4. It was shown that higher initial concentrations of MEX.HCl in an aqueous solution, increasing from 15 to 75 µg/mL, yielded higher binding affinities for TiO2 than Co3O4 and ZnO nanoparticles. The binding rate followed pseudo-second-order kinetics and the binding data were better modeled by the Freundlich isotherm than the Langmuir isotherm. These findings revealed that MEX.HCl binding occurred on the heterogeneous binding sites on TMONPs mainly by the physisorption mechanism via electrostatic attraction and hydrogen bonding.
GDF-15 and Hepciden as a therapeutic target for anemia in chronic kidney disease
Authors: farag naglaa makram , mousa mahmoud , elsayed eman , ismeil ahlam
Published: January 2023

Background
Anaemia is a common presenting feature among patients with chronic kidney disease (CKD) and associated with poor clinical outcomes. We evaluated the diagnostic validity of growth differentiation factor-15 (GDF-15) and hepcidin as it is not clear if they are useful as a biomarkers of anaemia among non-dialysis CKD egyptian patients.
Method
An analytical cross-sectional study was conducted among non-dialysis CKD patients (n = 60) and apparently healthy controls (n = 28) at Minia University maternity & children Hospital. Serum levels of GDF-15 and hepcidin were determined. Predictive logistic regression models were built and post estimation receiver operator characteristics were determined to evaluate diagnostic validity of hepcidin and GDF-15 for iron deficiency anaemia.
Results
Hepcidin and GDF-15 are significantly higher in cases than control p value (0.047,<0.0001) respectively. The predictive value of diagnosing anaemia among CKD patients using hepcidin and GDF-15 was 72.0%, 70.0%.There was a weak negative correlation between hepcidin levels and glomerular filtration rate GFR (r-175 =, p = 0.105) in CKD patients, and significant correlation between serum GDF-15 and haemoglobin (r = -0.897, p < 0.0001), ferritin (r = 0.489, P < 0.000), Iron (r=-0.314, P = 0.002), CRP (r = 0.409, P < 0.0001).
Conclusion
Hepcidin and GDF-15 is a potential biomarker for predicting anaemia connected with inflammation among CKD Egyptian patients.
Volcanic evolution of an ultraslow-spreading ridge
Authors: Stubseid Håvard , Bjerga Anders , Haflidason Haflidi , Pedersen Rolf
Published: January 2023

Nearly 30% of the ocean crust forms at mid-ocean ridges where the spreading rate is less than 20 mm per year. According to the seafloor spreading paradigm, oceanic crust forms along a narrow axial zone, becomes inactive, and is transported away from the rift valley. However, because quantitative age data of volcanic eruptions are lacking, constructing geological models for the evolution of ultraslow-spreading crust remains a major challenge. Here, we use sediment thicknesses acquired from more than 4000 km of sub-bottom profiler data combined with C14 ages from sediment cores to determine the age of the ocean floor of the oblique ultraslow-spreading Mohns Ridge at the segment scale and reveal a systematic pattern of young volcanism occurring outside axial volcanic ridges. We present the first age map of a mid-ocean ridge and find that nearly half of the 6-17 km wide inner rift valley floor has been rejuvenated by volcanic activity during the last 25 Kyr. High-resolution bathymetric observations of young volcanic structures at the rift flanks indicate that crustal accretion occurs across the width of the axial valley and implies that formation of ocean crust may take more than one million years at ultraslow-spreading ridges.
Research on the isolation and identification of black spot disease of Rosa chinensis in Kunming,China
Authors: Li Yanjie , Pu Meiying , Cui Yusi , Ju Gu , Chen Xi , Wang Louqin , Wu Hongzhi , Wang Chao
Published: January 2023

Through a survey of rose diseases in the South Tropical Garden in Kunming, China,it was found that black spot was the most common and serious disease of rose cultivated in the open air there, with an incidence of more than 90%. In this study, fungus isolation was performed on leaf samples of five black spot susceptible varieties of rose from the South Tropical Garden by tissue isolation. 18 strains of fungus were initially obtained, and 7 of them were finally identified to cause black spot symptoms on healthy leaves of rose after verification by Koch's rule. By observing the morphology of colonies and spores, and constructing a phylogenetic tree by combining molecular biology and multiple genes, 2 pathogenic fungus were identified, namely, Alternaria alternata and Gnomoniopsis rosae. G. rosae was the first pathogenic fungi of rose black spot isolated and identified in this study. The results of this study can provide a reference base for further research and control of the black spot disease of rose in Kunming.
Parent-mediated interventions versus usual care in children with autism spectrum disorders. A systematic review with meta-analysis and Trial Sequential Analysis.
Authors: Conrad Charlotte Engberg , Ziegler Sonja Martha Teresa , Bilenberg Niels , Christiansen Jens , Fagerlund Birgitte , Hermann Rikke , Jeppesen Pia , Jørgensen Caroline Kamp , Thomsen Per Hove , Jakobsen Janus Christian , Lauritsen Marlene Briciet
Published: January 2023

Background

Autism spectrum disorder encompasses diverse patterns of social-communication and repetitive, restricted behaviours, and is associated with a higher risk of comorbid medical and psychiatric disorders. Various interventions have been developed to reduce the negative consequences of autism spectrum disorder and improve levels of functioning. Within different frameworks of interventions, there is increasing interest in parent-mediated interventions. This systematic review with meta-analysis aims to synthesise the current evidence of the effects, both positive and adverse, of parent-mediated interventions on younger children with autism spectrum disorder and their parents.

Methods

Electronic searches will be conducted in Cochrane Central Register of Controlled Trials (CENTRAL), Medical Literature Analysis and Retrieval System Online (MEDLINE), Excerpta Medica database (EMBASE), Latin American and Caribbean Health Sciences Literature (LILACS), American Psychological Association PsycInfo (PsycInfo), Science Citation Index Expanded (SCI-EXPANDED). Randomised clinical trials of parent-mediated interventions for children with autism and a control-group of usual care, waiting list or no treatment will be included. Two reviewers will independently screen, select and collect data. The methodological quality of the included studies will be evaluated using Cochrane methodology. The primary outcome will be autism symptom severity as measured by the Autism Diagnostic Observation Schedule (ADOS). Secondary outcomes will be adaptive functioning, adverse effects, child language, child socio-communicative symptoms, child´s quality of life and parental quality of life. The meta-analysis will be performed with Trial Sequential Analysis.

Discussion

This is the study protocol for a systematic review and meta-analysis of parent-mediated interventions versus usual care for children with autism spectrum disorder. The results of the review will inform clinicians and parents about the current evidence of the effects, both positive and adverse, of parent-mediated interventions on younger children with autism spectrum disorder and their parents, through improved methodology and the inclusion of new studies.
Protocol registration: PROSPERO 385188