bluuebunny/crossref_metadata_2025 huggingface dataset:
Homologous Recombination Repair Defect May Predict Treatment Response to Peptide Receptor Radionuclide Therapy for Neuroendocrine Tumors
Authors: Zhu Mojun , Sonbol Mohamad Bassam , Halfdanarson Thorvardur , Hobday Timothy , Ahn Daniel , Ma Wen Wee , Bekaii-Saab Tanios
Published: June 2020

Lutetium-177-dotatate (177Lu-dotatate), a form of peptide receptor radionuclide therapy, was approved by the U.S. Food and Drug Administration for the treatment of advanced somatostatin receptor–positive gastroenteropancreatic neuroendocrine tumors (NETs) in 2018 based on the promising results of the NETTER-1 trial for grade 1–2 midgut NETs. Here, we present a patient with a grade 3 pancreatic neuroendocrine tumor and BRCA1 germline mutation who had a significant response to 177Lu-dotatate.
State of the Science and Future Directions for Liquid Biopsies in Drug Development
Authors: Narayan Preeti , Ghosh Soma , Philip Reena , Barrett J. Carl , McCormack Robert T. , Odegaard Justin I. , Oxnard Geoffrey R. , Pracht Laurel J. , Williams P. Mickey , Kelloff Gary J. , Beaver Julia A.
Published: June 2020

With advances in precision oncology, liquid biopsies have shown promise as a minimally invasive means to diagnose cancer and guide treatment decisions. This commentary presents an assessment of the potential and the challenges of widespread use of liquid biopsy testing, based on the 2019 Accelerating Anticancer Agent Development Workshop.
Great Western railway electrification, UK: data challenges and visual solutions
Authors: Berryman Marta , Cheung Wales
Published: June 2020

A vast volume of documentation was generated by the £3 billion electrification of the Great Western railway in the UK. It was therefore critical to have early agreed requirements and well-configured information management systems, automation and visualisation to control and manage documentation effectively. Displaying the right information at the right time to the right people gave the programme team full control to make informed decisions, as well as ensuring correct instructions were given to the supply chain. This paper presents some challenges faced by the programme regarding data and information management, and the solutions developed to resolve them. These ranged from better application of available systems and processes to the development of visualisation tools and automation to accelerate the final stages of the programme.
Electrochemical study on steel corrosion in coral aggregate seawater concrete
Authors: Da Bo , Yu Hongfa , Ma Haiyan , Chen Da , Wu Zhangyu , Guo Jianbo
Published: June 2020

In order to improve the durability of coral aggregate seawater concrete (CASC) structures, the influences of exposure time, concrete strength, concrete cover thickness, steel type and inhibitor addition method on the steel corrosion behavior of CASC were investigated and the law of steel corrosion in CASC was obtained. This showed that the steel anticorrosion capacity of CASC structures in the marine environment is 316 stainless steel > new organic coated steel > common steel; this suggests common steel should not be used in CASC structures. In addition, both traditional addition and preabsorption of an amino alcohol inhibitor (AA) result in the enhancement of the anticorrosion capacity of CASC. Moreover, the effect of anticorrosion by preabsorption is better than by traditional addition. Therefore, for CASC structures in marine engineering, it is recommended to choose new organic coating steel, that the thickness of the concrete cover be at least 55 mm, and that the concrete strength reach C50 and preabsorption of AA. In this way, the durability of a CASC structure can be improved and its effective service life can be prolonged.
Sticky models
Authors: Harris Anna , Nott John
Published: June 2020

This paper explores the material histories which influence contemporary medical education. Using two obstetric simulators found in the distinct teaching environments of the University of Development Studies in the north of Ghana and Maastricht University in the south of the Netherlands, this paper deconstructs the material conditions which shape current practice in order to emphasise the past practices that remain relevant, yet often invisible, in modern medicine. Building on conceptual ideas drawn from STS and the productive tensions which emerge from close collaboration between historians and anthropologists, we argue that the pull of past practice can be understood as a form of friction, where historical practices ‘stick’ to modern materialities. We argue that the labour required for the translation of material conditions across both time and space is expressly relevant for the ongoing use and future development of medical technologies.
UPAYAPENINGKATAN PARTISIPASI ORANG TUA DAN KUALITAS PENDIDIK PADA PENDIDIKAN ANAK USIA DINI DI INDONESIA
Authors: Cholimah Nur
Published: June 2020

Salah satu masalah dalam  PAUD adalah masih kurang pemahaman masyarakat tentang PAUD. Orang tua belum menyadari bahwa tanggung jawab terbesar mendidik ada pada orang tua, dan pendidik yang masih banyak yang belum kreatif, inovatif, dan menguasai tentang konsep PAUD. Di sisi lain untuk dapat menjadikan anak cerdas baik IQ, emosionalnya, dan spiritual dibutuhkan kerja sama yang baik dari sekolah, orang tua/ keluarga, maupun dari masyarakat. Kesenjangan yang dalam masyarakat adalah masih minimnya pemahaman orang tua dalam turut mendidik anak atau menstimulasi anaknya menuju pertumbuhan dan perkembangan yang optimal, sehingga berdampak pada ”kualitas” pengasuhan dan pendidikan orang tua terhadap anaknya, sehingga tidak sejalan dengan sekolah. Sehingga perlu diupayakan pemahaman bagi masyarakat tentang konsep pendidikan anak usia dini dan peran penting orang tua dalam pendidikannya. Oleh sebab itu, diperlukan usaha untuk mengoptimalkan peran orang tua terhadap PAUD. Dalam rangka mengoptimalkan peran orang tua terhadap PAUD setidaknya meliputi tiga aspek, yaitu : interaksi orang tua- anak, komunikasi orang tua- guru, dan penyediaan sarana dan lingkungan edukasi. Ketiga aspek tersebut merupakan kesatuan yang saling melengkapi. Kata Kunci: Partisipasi Orang Tua, Kualitas Pendidik, PAUD
Pengaruh Perbedaan Metode Pengeringan pada Karakteristik Sensori dan Kimiawi Tape Ketan Hitam Instan
Authors: Audia Widia Putri , Handayani Mustika Nuramalia
Published: June 2020

Pengeringan alami dengan cara penjemuran pada tape ketan hitam instan diduga memicu terjadinya cross linking yang menyebabkan kerusakan produk. Tujuan penelitian ini adalah (1) mengetahui karakteristik sensori dan kimiawi tape ketan hitam instan yang dikeringkan dengan penjemuran, menggunakan oven, dan dengan menggunakan microwave oven; (2) mengetahui efektivitas pengeringan dalam mengendalikan mikroorganisme pada pembuatan tape ketan hitam instan. Penelitian ini menggunakan metode Rancangan Acak Lengkap (RAL) dengan tiga perlakuan pengeringan, yakni metode pengeringan penjemuran, oven dan microwave oven. Hasil penelitian menunjukkan bahwa tape ketan hitam instan yang dikeringkan dengan penjemuran paling disukai konsumen pada atribut warna dan aroma (untuk sampel kering sebelum diseduh), atribut rasa, tekstur dan kenampakan (untuk sampel sesudah diseduh). Karakteristik kimia tape ketan hitam instan yang dikeringkan dengan penjemuran (kadar air 7,43%; kadar alkohol 0,39%); oven (kadar air 7,57%; kadar alkohol 0,26%); microwave oven (kadar air 6,35%; kadar alkohol 0,35%). Pengeringan menggunakan oven dan microwave oven dapat mengendalikan mikroorganisme pada tape ketan hitam instan.
PENERAPAN MODEL PEMBELAJARAN PROJECT BASED LEARNING (PjBL) PADA KOMPETENSI DASAR MELAKUKAN DASAR PENGAWETAN PADA OLAHAN SUSU SEGAR
Authors: Liawati Lia , Handayani Sri , Rahayu Dwi Lestari
Published: June 2020

Penelitian ini bertujuan untuk mengetahui keterlaksanaan sintak dan hasil belajar siswa dari penerapan model pembelajaran Project Based Learning pada kompetensi dasar melakukan dasar pengawetan. Metode penelitian yang digunakan adalah Penelitian Tindakan Kelas yang dilakukan dalam 3 siklus. Setiap siklus terdiri dari perencanaan, pelaksanaan, pengamatan, dan refleksi. Objek penelitian ini adalah peserta didik kelas X TPHP 3 jurusan Teknologi Pengolahan Hasil Pertanian SMK Negeri 1 Kuningan. Hasil belajar siswa diukur menggunakan tes objektif (pre-test dan post-test), lembar observasi sikap, lembar penilaian keterampilan, lembar observasi proses pembelajaran, dan wawancara. Model pembelajaran Project Based Learning (PjBL) terlaksana dengan baik. Hasil penelitian menunjukkan adanya peningkatan hasil belajar siswa. Hal ini ditunjukkan oleh: (1) keterlaksanaan proses pembelajaran berjalan dengan sangat baik, (2) ketercapaian KKM pada aspek kognitif yaitu 76% pada siklus 1, 88% pada siklus II, dan 100% pada siklus III, (3) rata-rata nilai afektif pada indikator spiritual, jujur, tanggung jawab, disiplin, percaya diri, dan sopan santun mengalami peningkatan pada siklus I ke siklus II dan III, (4) rata-rata nilai psikomotorik siswa termasuk ke dalam katagori “sangat baik”.
PENGEMBANGAN BUKU DIGITAL INTERAKTIF ANALISIS KURIKULUM 2013 REVISI 2017 PADA MATA PELAJARAN PRODUKSI PENGOLAHAN KOMODITAS PERKEBUNAN DAN HERBAL
Authors: Purwanti Nuri , Handayani Sri , Handayani Mustika Nuramalia
Published: June 2020

Pelaksanaan Program Pengalaman Lapangan (PPL) merupakan program wajib yang harus diikuti oleh mahasiswa program studi keguruan, tanpa terkecuali pada mahasiswa Program Studi Pendidikan Teknologi Agroindustri. Dalam pelaksanaan PPL masih terdapat beberapa permasalahan, diantaranya adalah masih belum meratanya pemahaman mahasiswa terkait analisis Kurikulum 2013 Revisi 2017 dan masih kurangnya sumber belajar yang tersedia pada materi analisis Kurikulum 2013 Revisi 2017. Analisis kurikulum merupakan salah satu perangkat pembelajaran guru yang harus dikuasai oleh setiap pendidik. Penelitian ini bertujuan untuk mengembangkan sumber belajar dalam bentuk buku digital interaktif yang diterapkan pada materi analisis Kurikulum 2013 Revisi 2017 pada mata pelajaran Produksi Pengolahan Komoditas Perkebunan dan Herbal. Penelitian ini merupakan penelitian pengembangan yang mengadaptasi desain penelitian ADDIE yang meliputi tahapan Analyze, Design, Development, Implementation, dan Evaluation. Penilaian kelayakan buku digital ini ditinjau dari beberapa penilaian, diantaranya penilaian ahli media, penilaian ahli kurikulum, penilaian ahli materi, penilaian ahli bahasa, dan penilaian mahasiswa sebagai responden. Responden yang digunakan merupakan mahasiswa Program Studi Pendidikan Teknologi Agroindustri (PTAG) angkatan 2015 dan mahasiswa Program Profesi Guru Prajabatan Analisis Pengolahan Hasil Pertanian (PPG Prajabatan APHP) angkatan 2017. Hasil penelitian menunjukkan bahwa buku digital interaktif dinyatakan layak untuk dijadikan sebagai sumber belajar oleh ahli materi, dan dinyatakan sangat layak untuk dijadikan sebagai sumber belajar oleh ahli media, ahli kurikulum, ahli bahasa, dan mahasiswa sebagai responden.
PENERAPAN MODEL PEMBELAJARAN DISCOVERY LEARNING DENGAN BANTUAN MEDIA MINDJET MINDMANAGER PADA MATERI PENGEMASAN UNTUK MENINGKATKAN HASIL BELAJAR
Authors: Afifah Eneng Iif , Handayani Sri , Handayani Mustika Nuramalia
Published: June 2020

Penerapan beberapa model pembelajaran pada mata pelajaran produktif di SMKN 4 Garut belum sesuai dengan yang diharapkan karena siswa kurang paham dengan apa yang dilakukan oleh dirinya, sehingga guru masih mendominasi dalam proses pembelajaran dan menyebabkan hasil belajar yang diperoleh siswa kurang optimal. Salah satu model pembelajaran yang dapat membuat siswa terampil mengidentifikasi dan merumuskan masalah, melakukan pembuktian dalam rumusan masalahnya, hingga pada akhirnya siswa mampu menarik kesimpulan terkait solusi pada masalah tersebut adalahdiscovery learning dengan bantuan media mindjet mindmanager. Tujuan penelitian ini adalah untuk mengetahui keterlaksanaan model pembelajaran discovery learning dengan bantuan media mindjet mindmanager dan hasil belajar siswa pada materi pengemasan. Penelitian dilakukan dengan metode Penelitian Tindakan Kelas (PTK) dalam 3 siklus. Setiap siklus terdiri dari perencanaan, pelaksanaan, pengamatan dan refleksi. Subjek penelitian ini adalah siswa kelas X-A APHP. Hasil penelitian menunjukkan 1) Keterlaksanaan model pembelajaran discovery learning dengan bantuan mediamindjet mindmanager terlaksana dengan sangat baik. 2) Adanya peningkatan hasil belajar siswa dilihat dari ketercapaian KKM pada aspek kognitif sebesar 70% pada siklus I, 77% pada siklus II dan 100% pada siklus III, 3) penerapan model pembelajaran mampu menumbuhkan sikap kerja siswa yang meliputi disiplin, bekerja sama, kreativitas, keselamatan kerja dan menjaga kebersihan lingkungan, 4) Hasil penilaian psikomotor siswa pada siklus II menunjukan bahwa sebagian besar siswa memperoleh nilai baik sampai sangat baik pada komponen penilaian persiapan, hasil dan waktu praktikum, namun pada aspek proses praktikum mendapatkan nilai cukup baik sampai sangat baik.
PENGGUNAAN TEPUNG PISANG KEPOK (MUSA PARADISIACA FORMATYPICA) PADA PEMBUATAN COOKIES
Authors: Azizah Dewi Nur , Adianti K P
Published: June 2020

Terigu adalah tepung yang berasal dari bulir gandum yang saat ini menjadi bahan utama dalam pembuatan berbagai makanan di Indonesia, sehingga tingkat impor gandum di Indonesia sangat tinggi. Salah satu usaha yang dapat dilakukan untuk mencegah hal tersebut adalah dengan mengurangi penggunaan terigu di masyarakat dengan menggunakan tepung komposit. Salah satu bahan pangan yang dapat dijadikan tepung komposit adalah pisang kepok. Penelitian ini bertujuan untuk mengetahui pengaruh perbandingantepung pisang kepok dan terigu terhadap karakteristik cookieslidah kucing danmendapatkan perbandingantepung pisang kapokdan teriguyang tepat untuk menghasilkan cookieslidah kucing dengan karakteristik yang baik dan disukai panelis. Pada penelitian ini digunakan metode percobaan (eksperimental method)dengan menggunakan Rancangan Acak Kelompok (RAK)yang diulang sebanyak tiga kalidengan empatperlakuan perbandingan tepung pisangkepokdan terigu, yaitu A =0%:100%, B = 25% : 75%,C =50% : 50%, dan D = 75% : 25%. Pengujian yang dilakukan meliputi analisis kimia,yaitu kadar air dan abu; analisis fisik,yaitu uji tekstur; dan uji organoleptik dengan metode hedonikterhadap warna, aroma, kerenyahan, rasa, dan kenampakan keseluruhan.Hasil penelitian menunjukkan bahwa perbandingan tepung pisang kepok dan terigu sebesar25%: 75%menghasilkancookieslidah kucing dengan karakteristik yang baik dan disukai panelis dari segiwarna, aroma, kerenyahan,rasa,dan kenampakan keseluruhandengan rata-rata kadar air 2,34 %; kadar abu 2,15%;dantekstur sebesar 1,42mm/g/dt.
PENGGUNAAN GUM ARAB SEBAGAI BULKING AGENT PADA PEMBUATAN MINUMAN SERBUK INSTAN LABU KUNING DENGAN MENGGUNAKAN METODE FOAM MAT DRYING
Authors: Aliyah Qonitah
Published: June 2020

Labu kuning memiliki kandungan zat gizi yang tinggi terutama senyawa β-karoten. Salah satu pengolahan labu kuning adalah minuman serbuk instan. Salah satu metode pembuatan minuman serbuk instan adalah metode foam mat drying. Penelitian ini bertujuan untuk mengetahui pengaruh penggunaan gum arab (10%, 15%, dan 20%) yang digunakan sebagai bulking agent terhadap karakteristik minuman serbuk instan labu kuning. Penelitian ini menggunakan Rancangan Acak Lengkap yang dianalisis dengan uji sidik ragam pada taraf kepercayaan 95% dan 99%. Dilakukan pula uji DMRT sebagai uji lanjut pada taraf kepercayaan 95%. Penggunaan gum arab berpengaruh terhadap rendemen tetapi tidak berpengaruh terhadap kadar air, vitamin C, dan daya kelarutan. Perlakuan terbaik minuman serbuk instan labu kuning berdasarkan karakteristik dan organoleptik diperoleh pada perlakuan konsentrasi gum arab 15%. Minuman serbuk instan labu kuning perlakuan terbaik memiliki karakteristik sebagai berikut: rendemen 9,975%; kadar air 4,55%; vitamin C 33%; dan daya kelarutan 177,17 detik.
Pengaruh Integrasi Rantai Pasokan Terhadap Keunggulan Bersaing Melalui Kinerja Rantai Pasokan pada Peternak Sapi Perah di Kabupaten Bandung Barat
Authors: Yun Yun , Kurniawan Asep
Published: June 2020

Abstract.Livestock products, especially cow's milk, have related constraints that are easily damaged so that they require more handling. Especially in cold supply chains and transportation speeds. Problems in the food product supply chain, namely the value received by each member (suppliers, manufacturers and distributors) are still not balanced, especially at the upstream level, especially breeders, which is the starting point of the supply chain, obtaining low value. This indicates that the performance of the supply chain of cow's milk products is still low, but it should be noted also the competitive advantages that run the supply chain activities. This study wants to know the effect of supply chain integration on competitive advantage through supply chain performance. This research is quantitative research using the partial least square (PLS-SEM) method. The population in this study is cattle ranchers in West Bandung Regency The results of this study can explain the competitive advantages that are influenced by supply chain integration through supply chain performance.Keyword. stock products, supply chain, competitive advantage  Abstrak.Produk peternakan khususnya susu sapi memiliki kendala terkait mudah rusak, sehingga memerlukan penanganan yang lebih. khususnya dalam rantai pasokan dingin dan kecepatan transportasi. Masalah dalam rantai pasokan produk pangan yaitu nilaiyang diterima masing – masing anggota (supplier, manufaktur dan distributor)  masih belum seimbang terutama di tingkat upstream khususnya peternak yang menjadi titik awal dari rantai pasokan memperoleh value yang rendah. Hal ini mengindikasikan  akan kinerja rantai pasokan produk susu sapi masih rendah, tetapi perlu diperhatikan juga Keunggulan kompetitif yang menjalankan aktivitas rantai pasokan tersebut. Kajian ini ingin mengetahui pengaruh integrasi rantai pasokan terhadap keunggulan bersaing melalui kinerja rantai pasokan. Penelitian ini bersifat penelitian kuantitatif dengan menggunakan metode partial least square (PLS-SEM). Populasi pada penelitian ini yaitu peternak sapi di di Kabupaten Bandung Barat Hasil dari penelitian ini dapat menjelaskan keunggulan bersaing yang dipengaruhi integrasi rantai pasokan melalui kinerja rantai pasokan.Kata Kunci. produk peternakan, rantai pasokan, keunggulan bersaing
Marital Status dan Gender: Investigasi Kepuasan Kerja Karyawan Hotel
Authors: Andriani Rian , Disman Disman
Published: June 2020

Abstract. For employees in the hospitality industry, employee job satisfaction is an important factor because it will affect customer perceptions of service. Job satisfaction is an interesting topic to discuss, favoring companies in the field of research services at the front line. Companies must improve and enhance job satisfaction, through control variables that can increase job satisfaction such as marital status (single or married) and gender differences (male or female). This study discusses analyzing any indicators that give high priority to the satisfaction of hotel frontline employees. This study discusses differences in marital status and gender that affect job satisfaction in employees at hotels. The study uses a survey conducted on 152 frontline employees at three hotels in the city of Bandung. Presentation of data in table form or frequency distribution and cross tabulation (crosstab) with an analysis of trend trends in research, both those included in the low, medium or high categories. The results of this study provide evidence that frontline employees in hotels have the desire to achieve success in work (achievement), have responsibility in work, have a good working relationship between employees (interpersonal relations) and company policies and administration to get satisfaction in the category high.Keywords: Gender; Frontline Hotel employees; Job Satisfaction; Marital Status Abstrak. Pada karyawan di industri perhotelan, kepuasan kerja karyawan adalah faktor penting karena akan mempengaruhi persepsi pelanggan mengenai layanan. Kepuasan kerja merupakan topik yang selalu menarik untuk diteliti, dengan penekanan pada perusahaan di sektor jasa terutama penelitian pada karyawan frontline. Perusahaan harus memelihara dan meningkatkan kepuasan kerja karyawan, melalui control variable yang dapat mempengaruhi kepuasan kerja seperti marital status (lajang atau menikah) dan perbedaan gender (pria atau wanita). Penelitian ini bertujuan untuk menganalisis indikator apa saja yang memberikan pengaruh tinggi pada kepuasan kerja karyawan frontline hotel. Penelitian ini meneliti apakah perbedaan marital status dan gender mempengaruhi kepuasan kerja terutama pada karyawan frontline di hotel. Penelitian dengan menggunakan survei dilakukan terhadap 152 karyawan frontline pada lima hotel di Kota Bandung. Penyajian data dalam bentuk tabel atau distribusi frekuensi dan tabulasi silang (crosstab) dengan analisis ini akan diketahui tren dalam temuan penelitian, baik yang termasuk dalam kategori rendah, sedang atau tinggi. Hasil Penelitian ini memberikan bukti empiris bahwa karyawan frontline di hotel memiliki keinginan untuk mencapai kesuksesan dalam pekerjaan (prestasi), memiliki tanggung jawab dalam pekerjaan, memiliki hubungan kerja yang baik antara karyawan (hubungan interpersonal) dan kebijakan dan administrasi perusahaan untuk mencapai kepuasan kerja dalam kategori tinggi.Kata Kunci: Gender; Karyawan Frontline Hotel ;Kepuasan Kerja; Marital Satus
Vol 10 No Maret 2019
Authors: Setiawan Yana
Published: June 2020

Vol 10 No Maret 2019
KKTC’de Yaşanan Kadın Cinayetlerinin Basındaki Yansımaları: Ana Akım ve Alternatif Gazete Karşılaştırması
Authors: CEYLANLI Barış , KANLI İzlem
Published: June 2020

Bu araştırmanın amacı Kuzey Kıbrıs Türk Cumhuriyeti’nde yaşanan kadın cinayetlerinin ana akım ve alternatif basında yansımalarının analiz edilmesidir. Kuzey Kıbrıs, nüfus bakımından küçük bir coğrafya olup, yazılı basının halka etki oranı göreceli olarak daha fazladır. Bu açıdan değerlendirildiğinde gazetelerin kadın cinayetleri eksenindeki tutumunu incelemek önem taşır. 2014 ile 2018 yılları arasında Kuzey Kıbrıs basın organları arasından seçilmiş ana akım ve alternatif akım örneği olarak Kıbrıs ve Afrika gazeteleri araştırma kapsamında analiz edilmiştir. Kadın cinayetlerinin ana akım ve alternatif basın üzerinden aktarım farklılıklarının, değişken temsiller bakımından incelenmesi esas amaç olup bu temsiller içerik analizi yöntemiyle değerlendirilmiştir. Ortaya çıkan bulgular, cinayetlerin aktarımında kullanılan temsillerin toplumsal cinsiyet temsilleri bağlamında eşit ve adil bir çerçeveden verilmediğini; kadına yönelik uygulanan şiddet olaylarının kullanılan dil ve temsillerle birlikte dolaylı olarak da olsa meşrulaştırılmaya çalışıldığını, bu bağlamda basının şiddet olayları ve çalışma kapsamında kadın cinayetlerine yönelik kitleye haber aktarımındaki tutumunun olumsuz olduğunu göstermektedir. Genel olarak değerlendirildiğinde her iki gazetenin kadın cinayeti haberlerine manşette ve içerikte yer veriyor olmaları kadın cinayetleri bağlamda farkındalık yaratan bir husus olarak nitelendirilebilecekken, haberlerin gerek veriliş şekli, gerekse içerikleri değerlendirildiğinde bu haberlerin daha çok sansasyon yaratmaya; kadın cinayetine dair haberleri şiddet dolu ifade ve fotoğraflarla lanse ederek ise şiddeti normalleştirip meşrulaştırmaya yaradığı gözlenir.
Analysis of internal defects in 3D braided composites based on ultrasonic C-scan technique
Authors: Xiao Z T , Guo Y M , Geng L , Wu J , Zhang F , Wang W , Liu Y B
Published: June 2020

Defects can form within 3D braided composites as a result of their special production processes, which can affect the mechanical performance of the composites. Thus, it is absolutely essential to test for and analyse different types of defect. This paper reports on the detection of
specific artificial defects in 3D braided composites, assessed using an ultrasonic system with typical examination techniques for non-destructive testing (NDT) and employing an ultrasonic C-scan technique to identify the artificial defects. Eight types of artificial defect are embedded and
detected in these 3D braided composites. The study shows that this ultrasonic C-scan technique is an effective tool for inspecting the state of failure of 3D braided composites.
A educación galega hoxe: consideracións históricas, realidades e perspectivas
Authors: Barreiro Rodríguez Herminio
Published: June 2020

Texto de Herminio Barreiro sobre a educación galega actual, publicado en 2001.
A Generalization of Reciprocal Exponential Model: Clayton Copula, Statistical Properties and Modeling Skewed and Symmetric Real Data Sets
Authors: Mansour M. M. , Butt Nadeem Shafique , Yousof Haitham , Ansari S. I. , Ibrahim Mohamed
Published: June 2020

We introduce a new extension of the reciprocal Exponential distribution for modeling the extreme values. We used the Morgenstern family and the clayton copula for deriving many bivariate and multivariate extensions of the new model. Some of its properties are derived. We assessed the performance of the maximum likelihood estimators (MLEs) via a graphical simulation study. The assessment was based on the sample size. The new reciprocal model is employed for modeling the skewed and the symmetric real data sets. The new reciprocal model is better than some other important competitive models in statistical modeling.
Direct torque control of permanent magnet synchronous motor for electric vehicles
Authors: ÇAVUŞ Bariş , AKTAŞ Mustafa
Published: June 2020

Permanent magnet synchronous motors (PMSM) are highly preferred in electric vehicles due to their high efficiency, good torque-speed characteristics, simple structure and long life. In this paper, the simulation study of direct torque controlled PMSM for electric vehicles was performed in MATLAB by direct torque control (DTC) method using different speed control and speed estimation methods, because output parameters of DTC method such as torque and current, have high ripple, and this ripple should be reduced for electric vehicle. Due to the simple structure of the DTC and its low dependence on the system parameters, it is widely used in alternative current motors. When DTC is used in PMSM drive, it is known that although it has fast dynamic response when it is compared to other vector control methods, the ripple in the torque and flux increases. In this study, direct torque controlled PMSM is tried to be minimized by using different speed control methods and speed estimation methods. For this purpose, proportional-integral (PI), fuzzy logic and sliding mode speed controller are used as speed controllers and their performances are compared. In addition, speed sensor less direct torque control of PMSM was performed by using sliding mode observer and model reference adaptive system (MRAS) observer. As a result of the simulation studies, it was found that sliding mode speed control method provides less ripples in the torque, better speed control and less energy consumption. Furthermore, as a speed observer, the sliding observer gives better results in speed estimation and provides less energy consumption.
Globalización, política criminal y rumbos del derecho penal en el contexto de la sociedad del riesgo
Authors: López Rojas Dayán Gabriel , Martínez Montenegro Isnel
Published: June 2020

La presente investigación se orienta a analizar el impacto que la globalización planetaria genera sobre la política criminal y el derecho penal en la denominada “sociedad del riesgo”. Tal problemática constituye uno de los aspectos que mayor preocupación despierta en la agenda criminológica actual, con motivo de los peligros que estas tendencias suponen para el respeto de los derechos y las garantías fundamentales de los ciudadanos, tradicionalmente interpretados como límites al ius puniendi en el contexto de un Estado de derecho. El análisis teórico que aquí se desarrolla representa una investigación a nivel básico, cuyo principal resultado es la caracterización de la política criminal y del derecho penal de nuestros días, y concluye con la formulación de algunas propuestas que se estiman útiles en el propósito de configurar una política criminal coherente y razonable, las cuales pueden generalizarse a cualquier contexto en el que rija un sistema penal de corte democrático.
Del biocentrismo a la seguridad humana
Authors: Várgas-Chavez Iván , Luna Galván Mauricio , Torres Pérez Yina Luz
Published: June 2020

El presente artículo lleva a cabo un análisis del estatus de las actividades de extracción minera con respecto a la naturaleza como sujeto de derechos. Esto, en la medida en que representa una grave amenaza no solo para la fauna y la flora de las zonas en las que se adelanta minería, sino para el ser humano. Por esta razón el ordenamiento jurídico ha avanzado en la materia al plantear la prohibición de realizar estas actividades en parques nacionales naturales, parques naturales de carácter regional, zonas de reserva forestales y zonas de páramos. Asimismo, las altas cortes han contribuido a proteger y preservar la naturaleza, como es el caso del páramo de Pisba, el cual fue reconocido como sujeto de derechos. Además de referir estos antecedentes, metodológicamente se realiza una caracterización del conflicto por la que se identifica y define el conflicto ambiental, se señala su ubicación, los aspectos sociales, el proceso y la forma cómo se resolvió para así demostrar la adopción de la teoría del biocentrismo en las decisiones judiciales tendientes a garantizar la protección de la naturaleza.
Validation of Diet History Questionnaire in Assessing Energy and Nutrient Intakes of Iranian Population
Authors: TOORANG Fatemeh , SASANFAR Bahareh , RAZEGHI JAHROMI Soodeh , EBRAHIMPOUR KOUJAN Soraiya , NARMCHESHM Saba , RAFEI Ali , ZENDEHDEL Kazem
Published: June 2020

Background: This study described validity of Diet History Questionnaire (DHQ) for assessing energy and nutrient intake among Iranian population.
Methods: A group of experienced nutritionists translated the DHQ to Farsi language and modified it based on Iranian food habits and cooking methods. We recruited 244 healthy adults with a mean age of 42.83 ± 0.75 yrs. from healthy individuals who were friends or relatives of patients in the Cancer Institute of Iran from April 2011 to February 2012. We used the DHQ to assess dietary intakes through interviews as well as at least four 24-h recalls one in every season. Reliability was estimated by comparing data of DHQ with mean intake from 24-hour recalls using deattenuated and energy-adjusted Spearman correlation coefficients. We classified dietary intakes of two methods into three groups to probe if DHQ correctly allocates subjects into different intake groups compared to reference method. The results are reported as percent of disagreement, adjacent agreement, and complete agreement.
Results: Deattenuated spearman correlation ranged from 0.18 for vitamin B12 and fat to 0.60 for sugar. It ranged from 0.13 for pantothenic acid to 0.60 for sugar in men and from 0.07 for fat to 0.58 for sugar in females. The complete agreement of methods ranged from 51% for selenium to 36% for carotene in the entire sample, from 50% for energy to 31% for niacin in males and from 49% for sugar to 27% for vitamin B12 in females.
Conclusion: The DHQ is a valid tool for assessing most nutrients intake among Iranian population. In addition, it is a proper instrument in categorizing individuals based on their dietary intakes.
Target Site Insensitivity Detection in Deltamethrin Resistant Culex pipiens Complex in Iran
Authors: ZEIDABADINEZHAD Reza , VATANDOOST Hassan , ABAI Mohammad Reza , DINPARAST DJADID Navid , RAZ Abbasali , SEDAGHAT Mohammad Mahdi , OSHAGHI Mohamad Ali , RAEISI Ahmad , ADIBI Neda
Published: June 2020

Background: Some mosquito species which belong to the Culex. pipiens complex are primary vectors for West Nile virus, Sindbis, Dirofilaria immitis, and many arboviruses. Knockdown resistance (kdr) mutations in the voltage-gated sodium channel (VGSC) gene of Cx. pipiens that is inherited, is one of the important threats for the efficacy of pyrethroids insecticides. Knockdown resistance (kdr) mutation, L1014F, is a well-defined mechanism of resistance to pyrethroids and DDT in many insect species. The aim of study was to determine the mechanisms of Insecticide resistance in this species
Methods: Specimens of Cx. pipiens, the major vector of West Nile virus, were obtained in Tehran, Iran by collecting larvae from polluted wastewater in Qarchak of Tehran. In 2016 Insecticide susceptibility tests were performed according to WHO methods with deltamethrin 0.05%. We focused on determination of this point mutation in the VGSC gene of Cx. pipiens by Real-time PCR.
Results: Our results revealed high levels of resistance to deltamethrin 0.05%. The lethal times i.e. LT50 and LT90 for deltamethrin were 2.1530 and 8.5117 h respectively. The result of Real-time PCR confirmed the presence of resistant genotype in all the members of tested population. This study is the first report on kdr genotyping of Cx. pipiens from Tehran and our results on the VGSC gene in position L1014F confirmed the TTA to TTT nucleotide change.
Conclusion: This finding will provide a clue for management of insecticide resistance in mosquito which are vectors of arboviruses and decision for replacement of novel approach for vector control.
Single Nucleotide Polymorphisms of FCRL3 in Iranian Patients with Behcet’s Disease
Authors: SHAHRAM Farhad , KAZEMI Javad , MAHMOUDI Mahmoud , JADALI Zohreh
Published: June 2020

Background: Both genetic and environmental factors influence, susceptibility to autoimmune disorders including Behcet’s disease (BD). FCRL3 (Fc receptor like 3 genes), a novel immunoregulatory gene, has recently been reported as a new promising candidate gene for general autoimmunity. This study was conducted to explore the potential association of FCRL3 polymorphisms with BD.
Methods: This study was conducted from 2010 to 2015 in Tehran University of Medical Sciences, Tehran, Iran. Four single-nucleotide polymorphisms of FCRL3 (rs7528684, rs11264799, rs945635, and rs3761959) were genotyped in 220 patients and 220 healthy controls. Typing of the polymorphisms in this case-control study was carried out using polymerase chain reaction-restriction fragment length polymorphism analysis.
Results: Analysis of the alleles revealed a significantly lower frequency of the A allele at the -169 site (rs7528684) in BD patients compared with that in controls (P=0.000, 66.4% versus 82%, χ2= 30.23). Moreover, a significant lower frequency of AA genotype and higher frequency of GG genotype was recorded for rs7528684. There was also relationship between posterior uveitis as a clinical sign of disease and polymorphism of allele A at the -169 site (P=0.015).
Conclusion: This study revealed a significant difference in both allele and genotype frequency at position -169 of FCRL3 gene between Iranian patients with BD and normal subjects. These data suggest FCRL3 gene polymorphisms might be the autoimmunity risk factor for BD.
Investigating the Prevalence of Sleep Disorder and the Impact of Sweet Almond on the Quality of Sleep in Students of Tehran, Iran
Authors: GHAFARZADEH Jafar , SADEGHNIIAT-HAGHIGHI Khosro , SADEGHPOUR Omid , AKBARPOUR Samaneh , AMINI-BEHBAHANI Farshad
Published: June 2020

Background: Insomnia is an important problem in medical sciences students and has implications for their educational progress. The current study aimed to estimate the prevalence of sleep disorders and investigating the impact of sweet almond on quality of sleep in students of the Tehran University of Medical Sciences (TUMS), Tehran, Iran who live in dormitories.
Methods: This is a before-after study conducted in 2017. At first, using the ISI questionnaire prevalence of sleep disorders was determined. Sweet almond was the study intervention. Each day, 10 almonds were given to 446 students for 14 d. At the end of the second week, again ISI questionnaire was filled. SPSS was used to analyze data. The McNemar, Wilcoxson Signed Ranks, and Repeated Measures tests were used.
Results: Out of 442 participants, 217 (49.1%) were female. Before intervention, 343 (77.6%) had insomnia and 99 (22.4%) had normal sleep. After intervention, 306 (69.2%) had insomnia and 136 (30.8%) had normal sleep. Having sweet almond for two weeks is associated with reducing insomnia (P<0.05). Investigating the almond impact in different categories also showed that it has a reducing impact on severe, mild, weak and normal sleep categories (P<0.05).
Conclusion: Sweet almond has impacts on quality of sleep of those students of the TUMS that are living in dormitories. Intervention programs to improve quality of sleep are necessary and with regard to the high prevalence of insomnia, students must be protected, guided and consulted.
Prevalence and Association of Human Papillomavirus with Esophageal Squamous Cell Carcinoma in Iran: A Systematic Re-view and Meta-Analysis
Authors: MOHAMMADPOUR Bashir , ROUHI Samaneh , KHODABANDEHLOO Mazaher , MORADI Masoud
Published: June 2020

Background: Human papillomavirus (HPV) can infect the epithelium of the esophagus, but so far there is no reliable and comprehensive evidence about the prevalence and association of HPV with esophageal cancer in Iran, as high incidence region. This study aimed to evaluate the prevalence and association of HPV with esophageal squamous cell carcinoma (ESCC) in Iran.
Methods: Relevant English and Persian articles published up to Aug 2017 and indexed in databases were reviewed. Frequency of HPV genotypes in ESCC cases and controls was surveyed according to regions of Iran. Data were meta-analyzed with random effects models using Comprehensive Meta-Analysis software.
Results: Overall, 14 studies were eligible including 1444 samples (1062 ESCC cases and 382 controls). HPV was positive in 269 (25.32%) of 1062 ESCC cases and in 65 (17.01%) of 382 controls. Total prevalence of HPV in both groups was estimated 0.256 (95%CI, 0.208%-0.310%). The prevalence of HPV-16 and HPV-18 was estimated 0.121 (95%CI: 0.087-0.183) and 0.046 (95%CI; 0.023-0.088), respectively. The difference in HPV prevalence in different regions of Iran was statistically significant (Q=18.20, df =4, P=0.001). In 6 case-control studies, the pooled odds ratio was estimated 1.99 (95%CI; 0.916-4.315).
Conclusion: High-risk HPVs were observed in ESCC cases and controls from different regions of Iran. The odds ratio indicates that the HPV infection in ESCC cases was approximately 2 fold more than the controls. More case-control studies in other populations with larger sample size are necessary.
Short Sleep Duration as a Risk Factor of Cardiovascular Disease in Korean Adults: Secondary Analysis of the Fifth Korean National Health and Nutrition Examination Survey
Authors: NOH Wonjung , MOON Heakyung
Published: June 2020

Background: Sleep durations shorter or longer than 7 h are associated with cardiovascular diseases. We aimed to investigate the association among sleep duration, risk factors of hypertension, and cardiovascular disease in South Korea using data from a recent large-scale survey.
Methods: Data produced by the Korea National Health and Nutrition Examination Survey (KNHANES) were subjected to multivariate logistic analysis. This cross-sectional, nationally representative survey was conducted from Jan 1 to Dec 31, 2011, by the Korean Center for Disease Control and Prevention. Overall, 6,466 participated. Data were analyzed using STATA version 13.0 (STATA Corp LP).
Results: The participants’ socioeconomic, physical, and lifestyle factors were statistically different between the two age groups (<65 yr and ≥65 yr). Shorter sleep durations were associated with hypertension in individuals younger than 65 yr of age. On the other hand, in participants aged ≥65 yr, both shorter and longer sleep durations were associated with hypertension, while shorter sleep durations were associated with cardiovascular diseases.
Conclusion: Unusual sleep durations are associated with an increased prevalence of cardiovascular disease among Korean adults. The effect of sleep duration appears to be more significant in individuals with hypertension, suggesting that the management of hypertension should be prioritized in patients older than 65 year.
Treatment Status of Patients with Β-Thalassemia Major in Northern Iran: Thalassemia Registry System
Authors: KOSARYAN Mehrnoush , KARAMI Hossein , DARVISHI-KHEZRI Hadi , AKBARZADEH Rosetta , ALIASGHARIAN Aily , BROMAND Khadijeh
Published: June 2020

Background: Electronic registry system of beta-thalassemia patients was run by Thalassemia Research Center (TRC) in 2017. The aim of the current study was presentation of therapeutic status in these patients at Mazandaran Province, Iran.
Methods: Therapeutic status variables including: Name of cities and hospitals, age and sex of patients, dependent and non-transfusion-dependent, starting age of the blood transfusion and iron-chelating agents, blood group and Rh, washed blood transfusion, abnormal antibody, transfusion reactions, mean hemoglobin during the last 3 months, type of iron chelators, iron chelators dosage, serum ferritin, and the use of hydroxyurea.
Results: Overall, 1831 patients were registered [891 male (48.7%)]. Mean age of patients was 30±9.7 yr. Average of hemoglobin levels for female and male were 9.1±5.1 and 9.4±6.3 gr/dl, respectively. Seventy-six percent of transfusion-dependent patients (1385) have received iso-group PRBC (packed red blood cells), after crossmatch. The most common blood group among patient was type O-positive (35.7%). Monotherapy with desferrioxamine was most type of used iron-chelating agent in these patients (47.2%). Mean of ferritin was 3300±7800 (ng/ml). Twenty-eight percent of patients (484) have received hydroxyurea; proportion of male and female was approximately equal. T2 weighted magnetic resonance imaging (MRIT2*) was measured in 62.2% of patients. Moderate and severe hepatosiderosis was 10.1% and 2.9%, respectively. Patients with moderate and severe cardiac siderosis were 11% and 5%, respectively.
Conclusion: Registry findings are valuable for treatment management and ensuring patients medications. It will also provide accessibility to various levels of patients’ information for health care managers and experts to help them make appropriate decisions.
Pulmonary Function Testing in Cement Transport Workers at Incheh Borun Border, Northeast of Iran
Authors: KHADEMI Javad , SADEGHI Mahdi , AHMADPOOR Rahmatollah , TAMADON YOLME Jalalodin , Ali MIRZAIE Mohammad , IZADI Nazanin , MEHRBAKHSH Zahra
Published: June 2020

Background: The aim of this study was to evaluate respiratory problems via pulmonary function testing in cement transport workers at Incheh Borun border in northeast of Iran in 2016.
Methods: The study was conducted on 358 male workers. All subjects were evaluated for respiratory symptoms via pulmonary function testing and completion of the American Thoracic Society questionnaire.
Results: Mean age of workers was 34.8±12.87 yr (age range 16-79 yr). Mean duration of employment was 6.1±4.36 yr. Most workers (75.4%) were illiterate or had elementary education. In addition, 56 (15.6%) subjects were smokers. Only three individuals (0.3%) had obstructive pattern. There was a significant relationship between age of workers and frequency of respiratory problems (P<0.05).
Conclusion: It is necessary to educate the workers about the health and safety regulations and use of personal protective equipment in workplace. In addition, periodic evaluation of respiratory function could help protect workers from developing occupational diseases.
New Diagnostic Algorithm for Chagas Disease: Impact on Ac-cess to Diagnosis and Out of Pocket Expenditures in Colombia
Authors: OLIVERA Mario J. , CHAVERRA Kevin A.
Published: June 2020

The article's abstract is no available.
Cloning of a Recombinant Plasmid Encoding PpSP42 Protein Fragment of Phlebotomus papatasi and expressing it in HEK-293T Eukaryotic Cell
Authors: MIANDOABI Touraj , BAHRAMI Fariborz , MOEIN VAZIRI Vahideh , AJDARY Soheila
Published: June 2020

The article's abstract is no available.
Fundamentos para una estrategia metodológica de aplicación de la jurisprudencia constitucional en el sistema judicial del Ecuador
Authors: Rodas Garcés Xavier
Published: June 2020

El presente artículo aborda los fundamentos teóricos del proceso de recepción de la jurisprudencia constitucional por parte de la jurisdicción ordinaria, en el contexto del modelo jurídico político instaurado por la Constitución de 2008 y la incidencia del neo­constitucionalismo y del Estado constitucional de derechos y justicia en la configuración de la nueva estructura del sistema de fuentes del Derecho en el Ecuador. Se examina la forma y condiciones en que debe desenvolverse la aplicación de la jurisprudencia constitucional como fuente formal y directa y el rol que tienen los jueces ordinarios en la concreción de los contenidos, principios y valores de la Constitución para superar la arraigada cultura del positivismo jurídico, el legalismo, el formalismo y la aplicación del literalismo normativo. Se plantea, a partir de determinados fundamentos teóricos, la necesidad de diseñar una estrategia metodológica para la aplicación de la jurisprudencia constitucional en la impartición de justicia en el Ecuador, en correspondencia con los nuevos paradigmas del ordenamiento jurídico nacional.
Analisa keberadaan lembaga kesejahteraan sosial anak (LKSA) di Kabupaten Sidoarjo
Authors: Sutinah Sutinah
Published: June 2020

Di Indonesia, diperkirakan jumlah anak terlantar sekitar 3,5 juta jiwa. Ini pun terbatas pada kelompok anak-anak yang yatim piatu dimana dari jumlah itu hanya sedikit di antara mereka yang terjangkau pelayanan sosial. Di Kabupaten Sidoarjo sendiri, jumlah anak terlantar, anak yatim dan anak yatim piatu yang tinggal di berbagai panti diperkirakan mencapai angka ribuan, bahkan lebih, dan tidak mustahil pula angkanya kini terus bertambah karena tekanan kemiskinan dan kondisi perekonomian yang tak kunjung stabil. Kegiatan sebagaimana dilaporkan, selain mencoba melakukan indentifikasi keberadaan LKSA di Kabupaten Sidoarjo dalam mengimplementasikan SNPA, juga sekaligus akan mengkaji dan merumuskan sebuah pendekatan dan model penanganan anak-anak yang terlantar yang ada di panti. Hasil akhir dari kegiatan ini diharapkan akan diperoleh informasi yang dapat digunakan sebagai bahan penyusunan kebijakan dalam mengoptimalkan peran LKSA dalam pemenuhan hak serta perkembangan anak asuhnya. Dengan demikian penelitian Analisa Keberadaan Lembaga Kesejahteraan Anak (LKSA) Di Kabupaten Sidoarjo menjadi penting untuk dilaksanakan. Metode yang digunkan pertama yaitu mengkaji dan menganilisis data sekunder. Kedua melakukan review. Dan ketiga yaitu melakukan penggalian data primer ke lapangan. Hasil studi ini menunjukkan kondisi LKSA di Kabupaten Sidoarjo masih banyak yang belum memenuhi standarisasi yang telah ditetapkan dalam SNPA. Kendala yang dihadapi pengurus LKSA dalam memenuhi standarisasi SNPA, selain berkaitan dengan keterbatasan dana dan SDM, juga karena jumlah anak asuh yang dilayani tidak sebanding dengan kemampuan pendanaan dan SDM yang diimiliki. Kedua, bagi anak-anak asuh panti, situasi problematik yang mereka hadapi terkait dengan kondisi LKSA.