bluuebunny/crossref_metadata_2025 huggingface dataset:
Large-scale control on the frequency of tropical cyclones and seeds: a consistent relationship across a hierarchy of global atmospheric models
Authors: Hsieh Tsung-Lin , Vecchi Gabriel A. , Yang Wenchang , Held Isaac M. , Garner Stephen T.
Published: September 2020

A diagnostic framework is developed to explain the response of tropical cyclones (TCs) to climate in high-resolution global atmospheric models having different complexity of boundary conditions. The framework uses vortex dynamics to identify the large-scale control on the evolution of TC precursors—first non-rotating convective clusters and then weakly rotating seeds. In experiments with perturbed sea surface temperature (SST) and $$\hbox {CO}_2$$

CO
2

concentration from the historical values, the response of TCs follows the response of seeds. The distribution of seeds is explained by the distribution of the non-rotating convective clusters multiplied by a probability that they transition to seeds. The distribution of convective clusters is constrained by the large-scale vertical velocity and is verified in aquaplanet experiments with shifting Inter tropical Convergence Zones. The probability of transition to seeds is constrained by the large-scale vorticity via an analytical function, representing the relative importance between vortex stretching and vorticity advection, and is verified in aquaplanet experiments with uniform SST. The consistency between seed and TC responses breaks down substantially when the realistic SST is perturbed such that the spatial gradient is significantly enhanced or reduced. In such cases, the difference between the responses is explained by a change in the ventilation index, which influences the fraction of seeds that develop into TCs. The proposed TC-climate relationship serves as a framework to explain the diversity of TC projection across models and forcing scenarios.
Altered DNA methylation profiles in blood from patients with sporadic Creutzfeldt–Jakob disease
Authors: Dabin Luke C. , Guntoro Fernando , Campbell Tracy , Bélicard Tony , Smith Adam R. , Smith Rebecca G. , Raybould Rachel , Schott Jonathan M. , Lunnon Katie , Sarkies Peter , Collinge John , Mead Simon , Viré Emmanuelle
Published: September 2020

Prion diseases are fatal and transmissible neurodegenerative disorders caused by the misfolding and aggregation of prion protein. Although recent studies have implicated epigenetic variation in common neurodegenerative disorders, no study has yet explored their role in human prion diseases. Here we profiled genome-wide blood DNA methylation in the most common human prion disease, sporadic Creutzfeldt–Jakob disease (sCJD). Our case–control study (n = 219), when accounting for differences in cell type composition between individuals, identified 38 probes at genome-wide significance (p < 1.24 × 10–7). Nine of these sites were taken forward in a replication study, performed in an independent case–control (n = 186) cohort using pyrosequencing. Sites in or close to FKBP5, AIM2 (2 probes), UHRF1, KCNAB2 successfully replicated. The blood-based DNA methylation signal was tissue- and disease-specific, in that the replicated probe signals were unchanged in case–control studies using sCJD frontal-cortex (n = 84), blood samples from patients with Alzheimer’s disease, and from inherited and acquired prion diseases. Machine learning algorithms using blood DNA methylation array profiles accurately distinguished sCJD patients and controls. Finally, we identified sites whose methylation levels associated with prolonged survival in sCJD patients. Altogether, this study has identified a peripheral DNA methylation signature of sCJD with a variety of potential biomarker applications.
Enhanced numerical integration scheme based on image compression techniques: Application to rational polygonal interpolants
Authors: Petö Márton , Duvigneau Fabian , Juhre Daniel , Eisenträger Sascha
Published: September 2020

Polygonal finite elements offer an increased freedom in terms of mesh generation at the price of more complex, often rational, shape functions. Thus, the numerical integration of rational interpolants over polygonal domains is one of the challenges that needs to be solved. If, additionally, strong discontinuities are present in the integrand, e.g., when employing fictitious domain methods, special integration procedures must be developed. Therefore, we propose to extend the conventional quadtree-decomposition-based integration approach by image compression techniques. In this context, our focus is on unfitted polygonal elements using Wachspress shape functions. In order to assess the performance of the novel integration scheme, we investigate the integration error and the compression rate being related to the reduction in integration points. To this end, the area and the stiffness matrix of a single element are computed using different formulations of the shape functions, i.e., global and local, and partitioning schemes. Finally, the performance of the proposed integration scheme is evaluated by investigating two problems of linear elasticity.
Primary glomus tumour of the pituitary gland: diagnostic challenges of a rare and potentially aggressive neoplasm
Authors: Quah Boon Leong , Donofrio Carmine Antonio , La Rosa Stefano , Brouland Jean-Philippe , Cossu Giulia , Djoukhadar Ibrahim , Mayers Helen , Shenjere Patrick , Pereira Marta , Pathmanaban Omar N. , Murtaza Muhammed O. , Gattamaneni Rao , Roncaroli Federico , Karabatsou Konstantina
Published: September 2020

Primary non-neuroendocrine tumours of the pituitary gland and sella are rare lesions often challenging to diagnose. We describe two cases of clinically aggressive primary glomus tumour of the pituitary gland. The lesions occurred in a 63-year-old male and a 30-year-old female who presented with headache, blurred vision and hypopituitarism. Neuroimaging demonstrated large sellar and suprasellar tumours invading the surrounding structures. Histologically, the lesions were characterised by angiocentric sheets and nests of atypical cells that expressed vimentin, smooth muscle actin and CD34. Perivascular deposition of collagen IV was also a feature. Case 2 expressed synaptophysin. INI-1 (SMARCB1) expression was preserved. Both lesions were mitotically active and demonstrated a Ki-67 labelling index of 30%. Next-generation sequencing performed in case 1 showed no mutations in the reading frame of 37 commonly mutated oncogenes, including BRAF and KRAS. Four pituitary glomus tumours have previously been reported, none of which showed features of malignant glomus tumour. Similar to our two patients, three previous examples displayed aggressive behaviour.
Minimizing shrinkage of acute brain slices using metal spacers during histological embedding
Authors: Bolduan Felix , Grosser Sabine , Vida Imre
Published: September 2020

The morphological structure of neurons provides the basis for their functions and is a major focus of contemporary neuroscience studies. Intracellular staining of single cells in acute slices is a well-established approach, offering high-resolution information on neuronal morphology, complementing their physiology. Despite major technical advances, however, a common histological artifact often precludes precise morphological analysis: shrinkage of the sampled tissue after embedding for microscopy. Here, we describe a new approach using a metal spacer, sandwiched between two coverslips to reduce shrinkage of whole-mount slice preparations during embedding with aqueous mounting medium under a coverslip. This approach additionally allows imaging the slices from both sides to obtain better quality images of deeper structures. We demonstrate that the use of this spacer system can efficiently and stably reduce the shrinkage of slices, whereas conventional embedding methods without spacer or with agar spacer cause severe, progressive shrinkage after embedding. We further show that the shrinkage of slices is not uniform and artifacts in morphology and anatomical parameters produced cannot be compensated using linear correction algorithms. Our study, thus, emphasizes the importance of preventing the deformation of slice preparations and offers an effective means for reducing shrinkage and associated artifacts during embedding.
Designed Ankyrin Repeat Protein (DARPin) to target chimeric antigen receptor (CAR)-redirected T cells towards CD4+ T cells to reduce the latent HIV+ cell reservoir
Authors: Patasic Lea , Seifried Janna , Bezler Valerie , Kaljanac Marcell , Schneider Irene C. , Schmitz Heike , Tondera Christiane , Hartmann Jessica , Hombach Andreas , Buchholz Christian J. , Abken Hinrich , König Renate , Cichutek Klaus
Published: September 2020

Chimeric Antigen Receptor (CAR)-redirected T cells show great efficacy in the patient-specific therapy of hematologic malignancies. Here, we demonstrate that a DARPin with specificity for CD4 specifically redirects and triggers the activation of CAR engineered T cells resulting in the depletion of CD4+ target cells aiming for elimination of the human immunodeficiency virus (HIV) reservoir.
Urine collection methods and dipstick testing in non-toilet-trained children
Authors: Diviney James , Jaswon Mervyn S.
Published: September 2020

Urinary tract infection is a commonly occurring paediatric infection associated with significant morbidity. Diagnosis is challenging as symptoms are non-specific and definitive diagnosis requires an uncontaminated urine sample to be obtained. Common techniques for sampling in non-toilet-trained children include clean catch, bag, pad, in-out catheterisation and suprapubic aspiration. The pros and cons of each method are examined in detail in this review. They differ significantly in frequency of use, contamination rates and acceptability to parents and clinicians. National guidance of which to use differs significantly internationally. No method is clearly superior. For non-invasive testing, clean catch sampling has a lower likelihood of contamination and can be made more efficient through stimulation of voiding in younger children. In invasive testing, suprapubic aspiration gives a lower likelihood of contamination, a high success rate and a low complication rate, but is considered painful and is not preferred by parents. Urine dipstick testing is validated for ruling in or out UTI provided that leucocyte esterase (LE) and nitrite testing are used in combination.
The Curinga–Girifalco Line in the framework of the tectonic evolution of the remnant Alpine chain in Calabria (southern Italy)
Authors: Festa Vincenzo , Cicala Marianna , Tursi Fabrizio
Published: September 2020

In the peri-Mediterranean metamorphic belts, the tectonic evolution of the Calabria–Peloritani terrane during the dominant compressive tectonics of the Eocene represents one of the most problematic points in palinspastic restorations. A matter of particular debate is its shortening, which could have occurred during the Alpine or the Apennine subduction. In this regard, a crucial joint is provided by the kinematics of one of the most relevant shear zones such as the Curinga–Girifalco Line, cropping out in central Calabria. This shear zone juxtaposed a nearly complete Hercynian crustal section (i.e. the Sila and Serre Unit) onto the remnants of the Castagna Unit. The data in the available literature on ductile kinematics from the south-eastern branch of the Curinga–Girifalco Line indicate a downward movement of the hanging wall. In the present paper we show new, ductile kinematic data and petrographic evidence from outcrops in the north-western and south-eastern branches of the Curinga–Girifalco Line. Our results highlight the coherent kinematics of the Eocene shortening during the Alpine subduction system, followed by (late Eocene?)Oligocene to early Miocene, dominantly ductile extensional reworking, relating to the Apennines subduction system.
Is dopaminergic medication dose associated with self-reported bruxism in Parkinson’s disease? A cross-sectional, questionnaire-based study
Authors: Verhoeff M. C. , Koutris M. , van Selms M. K. A. , Brandwijk A. N. , Heres M. S. , Berendse H. W. , van Dijk K. D. , Lobbezoo F.
Published: September 2020

Objectives

It is not clear whether dopaminergic medication influences bruxism behaviour in patients with Parkinson’s disease (PD). Therefore, the aims are to investigate (i) the prevalence of possible (i.e., self-reported) bruxism (sleep and awake) in PD patients, and (ii) whether the use of dopaminergic medication and other factors (viz., demographic characteristics, PD-related factors, and possible consequences of bruxism) are associated with possible bruxism (sleep or awake).

Materials and methods

This study concerns a secondary analysis of an earlier published study. Three hundred ninety-five PD patients (67.9 ± 8.6 years of age; 58.7% males) were included. The levodopa equivalent daily dosage (LEDD) was used as a measure of the dopaminergic medication level. Subsequently, a logistic regression analysis was performed for the dependent variables ‘awake bruxism’ and ‘sleep bruxism’, with the following predictors: gender, age, LEDD, time since PD diagnosis, temporomandibular disorder (TMD) pain, jaw locks, and tooth wear.

Results

The prevalence of possible awake and sleep bruxism was 46.0% and 24.3%, respectively. Awake bruxism was associated with sleep bruxism (OR = 8.52; 95% CI 3.56–20.40), TMD pain (OR = 4.51; 95% CI 2.31–8.79), and tooth wear (OR = 1.87; 95% CI 1.02–3.43). Sleep bruxism was associated with tooth wear (OR = 12.49; 95% CI 4.97–31.38) and awake bruxism (OR = 9.48; 95% CI 4.24–21.19). Dopaminergic medication dose was not associated with awake bruxism (OR = 1.0; 95% CI 0.99–1.00) or sleep bruxism (OR = 1.0; 95% CI 0.99–1.00).

Conclusion

Bruxism is a common condition in PD patients, but is not associated with the dopaminergic medication dose.

Clinical relevance

(Oral) health care providers should be alerted about the possibility of sleep and awake bruxism activity in PD patients, along with this activity’s possible negative health outcomes (viz., TMD pain, tooth wear).
Mental health and well-being from childhood to adulthood: design, methods and results of the 11-year follow-up of the BELLA study
Authors: Otto Christiane , Reiss Franziska , Voss Catharina , Wüstner Anne , Meyrose Ann-Katrin , Hölling Heike , Ravens-Sieberer Ulrike
Published: September 2020

Mental health and well-being are of great interest in health policy and research. Longitudinal surveys are needed to provide solid population-based data. We describe the design and methods of an 11-year follow-up of the German BELLA study in children, adolescents and young adults, and we report on age- and gender-specific courses of general health and well-being, long-term health-related outcomes of mental health problems, and mental health care use. The BELLA study is the module on mental health and well-being within the German Health Interview and Examination Survey for Children and Adolescents (KiGGS). Standardised measures were used at each of the five measurement points of the BELLA study. In the 11-year follow-up, young people aged 7–31 years participated (n = 3492). Individual growth modelling, linear regression and descriptive analyses were conducted. Self-reported general health and well-being were both better in younger (vs. older) and in male (vs. female) participants according to the data from all five measurement points. Mental health problems in childhood and adolescence (measured at baseline) predicted impaired health outcomes at 6-year and 11-year follow-ups. Approximately one out of four children with a diagnosed mental disorder was not undergoing mental health treatment. With its 11-year follow-up, the prospective longitudinal BELLA study provides new and solid data on mental health and well-being from childhood to adulthood in Germany, and these data are important for health promotion and prevention practices. These results are consistent with previous findings. Promising future analyses are planned.
Primary decompressive craniectomy in poor-grade aneurysmal subarachnoid hemorrhage: long-term outcome in a single-center study and systematic review of literature
Authors: Brandecker Simon , Hadjiathanasiou Alexis , Kern Tamara , Schuss Patrick , Vatter Hartmut , Güresir Erdem
Published: September 2020

Primary decompressive craniectomy (PDC) in patients with poor-grade aneurysmal subarachnoid hemorrhage (aSAH) in order to decrease elevated intracranial pressure (ICP) is controversially discussed. The aim of this study was to analyze the effect of PDC on long-term clinical outcome in these patients in a single-center cohort and to perform a systematic review of literature. Eighty-seven consecutive poor-grade SAH patients (World Federation of Neurosurgical Societies (WFNS) grades IV and V) were analyzed between October 2012 and August 2017 at the author’s institution. PDC was performed due to clinical signs of herniation or brain swelling according to the treating surgeon. Outcome was analyzed according to the modified Rankin Scale (mRS). Literature was systematically reviewed up to August 2019, and data of poor-grade aSAH patients who underwent PDC was extracted for statistical analyses. Of 87 patients with poor-grade aSAH in the single-center cohort, 38 underwent PDC and 49 did not. Favorable outcome at 2 years post-hemorrhage did not differ significantly between the two groups (26% versus 20%). Systematic literature review revealed 9 studies: Overall, a favorable outcome could be achieved in nearly half of the patients (49%), with an overall mortality of 24% (median follow-up 11 months). Despite a worse clinical status at presentation (significantly higher rate of mydriasis and additional ICH), poor-grade aSAH patients with PDC achieve favorable outcome in a significant number of patients. Therefore, treatment and PDC should not be omitted in this severely ill patient collective. Prospective controlled studies are warranted.
An immune challenge of female great tits decreases offspring survival and has sex-specific effects on offspring body size
Authors: Kubacka Justyna , Cichoń Mariusz
Published: September 2020

Investment in immunity is expected to decrease (costly immunity) or enhance (terminal investment) reproductive performance. Here, we tested the effects of activation of the immune system in female great tits (Parus major) on (1) their reproductive effort and (2) the survival and body condition of their offspring, controlling for chick sex. We injected females tending 3-day-old chicks with sheep red blood cells (SRBC) or saline (control) and recorded their provisioning rates 6 days later, during the expected peak of antibody production. We measured tarsus length and body mass in 11-day-old chicks and monitored changes in brood size. We found that female provisioning rates were unaffected by the SRBC challenge. An analysis without an outlier, however, showed a significant challenge-by-hatch date interaction. This interaction indicated that female provisioning rates decreased with hatch dates in the SRBC but not in the control nests, suggesting a stronger effect in later breeders. Chick body mass was not affected by female immunisation nor by its interaction with chick sex. However, we found a significant challenge-by-sex interaction on offspring tarsus. In SRBC nests, the difference in tarsus length between male and female chicks was lower than in controls, suggesting sex-dependent effects of the challenge on offspring structural growth. Finally, chick mortality was greater in SRBC nests compared with controls, but chick survival probability was not affected by sex. Overall, our results support the costly immunity but not the terminal investment hypothesis in the great tit.
Bending and free vibrational analysis of bi-directional functionally graded beams with circular cross-section
Authors: Huang Yong
Published: September 2020

The bending and free vibrational behaviors of functionally graded (FG) cylindrical beams with radially and axially varying material inhomogeneities are investigated. Based on a high-order cylindrical beam model, where the shear deformation and rotary inertia are both considered, the two coupled governing differential motion equations for the deflection and rotation are established. The analytical bending solutions for various boundary conditions are derived. In the vibrational analysis of FG cylindrical beams, the two governing equations are firstly changed to a single equation by means of an auxiliary function, and then the vibration mode is expanded into shifted Chebyshev polynomials. Numerical examples are given to investigate the effects of the material gradient indices on the deflections, the stress distributions, and the eigenfrequencies of the cylindrical beams, respectively. By comparing the obtained numerical results with those obtained by the three-dimensional (3D) elasticity theory and the Timoshenko beam theory, the effectiveness of the present approach is verified.
Resolving the trade-off between production and biodiversity conservation in integrated forest management: comparing tree selection practices of foresters and conservationists
Authors: Cosyns Hannes , Joa Bettina , Mikoleit Ronja , Krumm Frank , Schuck Andreas , Winkel Georg , Schulz Tobias
Published: September 2020

Integrating nature conservation effectively in forests managed for timber production implies reconciling a trade-off between ecological and economic objectives. In continuous cover forest management, this culminates in decisions about tree harvesting (or retention) determining both the prevalence of tree-related microhabitats in the forest and the economic viability of timber management. Applying an innovative mixed methods approach, we compare conservationists and foresters performing a tree selection exercise. We assess the outcomes of their forest management decisions quantitatively and explore their strategies and the underlying reasoning based on qualitative data. Our findings show that particularly the habitat trees differ greatly between the two groups: while conservationists retained almost exclusively large oaks at often high opportunity costs, foresters retained a notable number of smaller-diameter hornbeams. These differences are related to a different perception of opportunity costs of retention by both groups, as well as because they do not agree about how to value current tree-related microhabitats and their projection into the future. Such diverging patterns of reasoning imply incompatible interpretations of what constitutes a habitat tree. Our results indicate that it is important to apply benchmarks for evaluating ecological goals as well as to increase foresters’ and conservationists’ understanding about the motivations and restrictions of the respective counterpart. Our study points out a significant potential for (mutual) learning, and illustrates the complementarity of quantitative and qualitative research methods to examine tree selection behaviour.
Risk factors for implant failure following revision surgery in breast cancer patients with a previous immediate implant-based breast reconstruction
Authors: Frisell A. , Lagergren J. , Halle M. , de Boniface J.
Published: September 2020

Purpose

The aim of the current study was to evaluate risk factors and timing of revision surgery following immediate implant-based breast reconstruction (IBR).

Methods

This retrospective cohort included women with a previous therapeutic mastectomy and implant-based IBR who had undergone implant revision surgery between 2005 and 2015. Data were collected by medical chart review and registered in the Stockholm Breast Reconstruction Database. The primary endpoint was implant removal due to surgical complications, i.e. implant failure.

Results

The cohort consisted of 475 women with 707 revisions in 542 breasts. Overall, 33 implants were removed due to complications. The implant failure rate (4.7%) was lower without RT (2.4%) compared to RT administered after mastectomy (7.5%) and prior to IBR (6.5%) (p = 0.007). While post-mastectomy RT (OR 3.39, 95% CI 1.53–7.53), smoking (OR 3.90, 95% CI 1.76–8.65) and diabetes (OR 5.40, 95% CI 1.05–27.85) were confirmed as risk factors, time from completion of RT (> 9 months, 6–9 months, < 6 months) was not (OR 3.17, 95% CI 0.78–12.80, and OR 0.74, 95% CI 0.20–2.71). Additional risk factors were a previous axillary clearance (OR 4.91, 95% CI 2.09–11.53) and a history of a post-IBR infection (OR 15.52, 95% CI 4.15–58.01, and OR 12.93, 95% CI 3.04–55.12, for oral and intravenous antibiotics, respectively).

Conclusions

Previous axillary clearance and a history of post-IBR infection emerged as novel risk factors for implant failure after revision surgery. While known risk factors were confirmed, time elapsed from RT completion to revision surgery did not influence the outcome in this analysis.
Cellulose dissolution and regeneration using a non-aqueous, non-stoichiometric protic ionic liquid system
Authors: Berga Laura , Bruce Isobel , Nicol Thomas W. J. , Holding Ashley J. , Isobe Noriyuki , Shimizu Seishi , Walker Adam J. , Reid Joshua E. S. J.
Published: September 2020

The solubility of cellulose has been studied as a function of composition in the binary mixture of 1,1,3,3-tetramethylguanidine and propionic acid. In amine-rich compositions, greater quantities of cellulose can be dissolved than in the equimolar composition, a.k.a. the protic ionic liquid [TMGH][OPr]. By applying a methodology of a short period of heating followed by cooling, similar concentrations of cellulose can be achieved in a much shorter time period. Finally, regeneration of cellulose from solution can be achieved by altering the acid:amine molar ratio. In comparison to cellulose regenerated from these solutions using water as an antisolvent, cellulose regenerated with propionic acid exhibit a lower crystallinity as inferred from x-ray diffractometry, but a greater average molecular weight as inferred from gel permeation chromatography.
Another Look at Mode Intentionalism
Authors: Mitchell Jonathan
Published: September 2020

A central claim in contemporary philosophy of mind is that the phenomenal character of experience is entirely determined by its content. This paper considers an alternative calledMode Intentionalism. According to this view, phenomenal character outruns content because the intentional mode contributes to the phenomenal character of the experience. I assess a phenomenal contrast argument in support of this view, arguing that the cases appealed to allow for interpretations which do not require positing intentional modes as phenomenologically manifest aspects of experience.
The risk elicitation puzzle revisited: Across-methods (in)consistency?
Authors: Holzmeister Felix , Stefan Matthias
Published: September 2020

With the rise of experimental research in the social sciences, numerous methods to elicit and classify people’s risk attitudes in the laboratory have evolved. However, evidence suggests that attitudes towards risk may vary considerably when measured with different methods.
Based on a within-subject experimental design using four widespread risk preference elicitation tasks, we find that the different methods indeed give rise to considerably varying estimates of individual and aggregate level risk preferences. Conducting simulation exercises to obtain benchmarks for subjects’ behavior, we find that the observed heterogeneity in risk preference estimates across methods is qualitatively similar to the heterogeneity arising from independent random draws from the choice distributions observed in the experiment. Our study, however, provides evidence that subjects are surprisingly well aware of the variation in the riskiness of their choices. We argue that this calls into question the common interpretation of variation in revealed risk preferences as being inconsistent.
Flow intermittency negatively affects three phylogenetically related shredder stoneflies by reducing CPOM availability in recently intermittent Alpine streams in SW-Italian Alps
Authors: Piano Elena , Doretto Alberto , Falasco Elisa , Gruppuso Laura , Bona Francesca , Fenoglio Stefano
Published: September 2020

Several Alpine streams are currently facing recurrent summer drying events with detrimental consequences on stream detritivores, i.e., shredders, due to negative effects via changes the organic matter (CPOM) availability. We examined the ecological requirements of three phylogenetically related shredder genera belonging to the family of Nemouridae (Plecoptera), namely Nemoura, Protonemura and Amphinemura, in 14 Alpine streams recently facing recurrent summer flow intermittency events. We evaluated the overlap among their ecological niches measured in terms of hydraulic stress, substrate composition, changes in CPOM availability and competition with other shredder taxa (i.e., presence of individuals of other shredders) and we examined potential changes in their ecological niches between permanent and intermittent sites. The ecological niches of Protonemura and Amphinemura overlap broadly, but not with Nemoura, suggesting only partial potential competition. The reduced CPOM availability decreased the individual abundance of the three genera in intermittent sites, where they consistently preferred microhabitats with high CPOM availability and low competition with other shredder taxa, possibly due to food limitation. Overall, our results emphasize how the negative effect of flow intermittency on shredders in Alpine streams is mainly due to the decrease in CPOM availability, with consequent potential bottom up effects on stream ecosystem functionality.
Electrochemical removal of Bisphenol A from landfill leachate under Nordic climate conditions
Authors: Ambauen Noëmi , Weber Clara , Muff Jens , Hallé Cynthia , Meyn Thomas
Published: September 2020

This study investigated the applicability of electrochemical oxidation for landfill leachate treatment in climate areas, where cold temperatures prevail (like Northern Norway). Experiments were completed with pre-treated (coagulation/flocculation and separation) landfill leachate at 6 and 20 °C in order to assess the temperature influence on the degradation of the organic pollutant Bisphenol A and the fate of the ordinary wastewater parameters COD and nitrate. Furthermore, two different anode materials (Ti/Pt and Nb/BDD) and three different current densities (10, 43 and 86 mA cm−2) were compared. Additionally, the formation of the two groups of disinfection by-products, trihalomethanes and perchlorate, was monitored. A 99% removal of Bisphenol A was confirmed at 6 °C on both tested anode materials, but a current density of at least 43 mA cm−2 must be applied. Removal rates were on average 38% slower at 6 °C than at 20 °C. For comparison, Bisphenol A removal in clean electrolyte disclosed faster degradation rates (between 50 and 68%) due to absent landfill leachate matrix effects. The energy consumption for 99% Bisphenol A removal was 0.28 to 1.30 kWh m−3, and was on average 14% higher at 6 °C compared to 20 °C. Trihalomethanes were mainly formed on Pt anodes in the ppb range, while perchlorate was primarily formed at BDD anodes in the ppm range. Formation of disinfection by-products increased with increased applied current and temperature. Electrochemical oxidation was found to be a suitable treatment process for landfill leachate in cold climate areas by successfully meeting treatment goals.

Graphic abstract
Correction to: Novel noncontact charge density map in the setting of post-atrial fibrillation atrial tachycardias: first experience with the Acutus SuperMap Algorithm
Authors: Ramak Robbert , Chierchia Gian-Battista , Paparella Gaetano , Monaco Cinzia , Miraglia Vincenzo , Cecchini Federico , Bisignani Antonio , Mojica Joerelle , Al Housari Maysam , Sofianos Dimitrios , Kazawa Shuichiro , Overeinder Ingrid , Bala Gezim , Ströker Erwin , Sieira Juan , Osorio Thiago Guimaraes , Brugada Pedro , de Asmundis Carlo
Published: September 2020

The article “Novel noncontact charge density map in the setting of post-atrial fibrillation atrial tachycardias.
The effect of compliance with a perioperative goal-directed therapy protocol on outcomes after high-risk surgery: a before-after study
Authors: Boekel M. F. , Venema C. S. , Kaufmann T. , van der Horst I. C. C. , Vos J. J. , Scheeren T. W. L.
Published: September 2020

Perioperative goal-directed therapy is considered to improve patient outcomes after high-risk surgery. The association of compliance with perioperative goal-directed therapy protocols and postoperative outcomes is unclear. The purpose of this study is to determine the effect of protocol compliance on postoperative outcomes following high-risk surgery, after implementation of a perioperative goal-directed therapy protocol. Through a before-after study design, patients undergoing elective high-risk surgery before (before-group) and after implementation of a perioperative goal-directed therapy protocol (after-group) were included. Perioperative goal-directed therapy in the after-group consisted of optimized stroke volume variation or stroke volume index and optimized cardiac index. Additionally, the association of protocol compliance with postoperative complications when using perioperative goal-directed therapy was assessed. High protocol compliance was defined as ≥ 85% of the procedure time spent within the individual targets. The difference in complications during the first 30 postoperative days before and after implementation of the protocol was assessed. In the before-group, 214 patients were included and 193 patients in the after-group. The number of complications was higher in the before-group compared to the after-group (n = 414 vs. 282; p = 0.031). In the after-group, patients with high protocol compliance for stroke volume variation or stroke volume index had less complications compared to patients with low protocol compliance for stroke volume variation or stroke volume index (n = 187 vs. 90; p = 0.01). Protocol compliance by the attending clinicians is essential and should be monitored to facilitate an improvement in postoperative outcomes desired by the implementation of perioperative goal-directed therapy protocols.
Left-censored dementia incidences in estimating cohort effects
Authors: Weißbach Rafael , Kim Yongdai , Dörre Achim , Fink Anne , Doblhammer Gabriele
Published: September 2020

We estimate the dementia incidence hazard in Germany for the birth cohorts 1900 until 1954 from a simple sample of Germany’s largest health insurance company. Followed from 2004 to 2012, 36,000 uncensored dementia incidences are observed and further 200,000 right-censored insurants included. From a multiplicative hazard model we find a positive and linear trend in the dementia hazard over the cohorts. The main focus of the study is on 11,000 left-censored persons who have already suffered from the disease in 2004. After including the left-censored observations, the slope of the trend declines markedly due to Simpson’s paradox, left-censored persons are imbalanced between the cohorts. When including left-censoring, the dementia hazard increases differently for different ages, we consider omitted covariates to be the reason. For the standard errors from large sample theory, left-censoring requires an adjustment to the conditional information matrix equality.
My objectivity is better than yours: contextualising debates about gender inequality
Authors: Worsdale Rosie , Wright Jack
Published: September 2020

Absract

In this paper, we contribute to a growing literature in the philosophy of social science cautioning social scientists against context-independent claims to objectivity, by analyzing the recent proposal of a new Basic Index of Gender Inequality (BIGI) by Gijsbert Stoet and David Geary. Despite the many internal problems with BIGI, Stoet and Geary have had some success in positioning the index as an important corrective to the way in which gender inequality is measured in mainstream metrics like the Global Gender Gap Index (GGGI). We argue that this success is facilitated at least in part by the failure of GGGI’s proponents to adequately justify the methodological choices underpinning the index in relation to the context in which the index’s findings are intended to be used. In so doing, the authors of GGGI oversell the objectivity of the metric’s assessment of the state of global gender inequality—and it is this overselling that allows Stoet and Geary to present BIGI as a metric that corrects what they claim are systematic biases within GGGI. The case of BIGI and GGGI, we argue, suggests that the kind of epistemic modesty exhibited by recent operational approaches to objectivity is particularly important for social research on highly politically contested topics.
Hot Processing of Powder Metallurgy and Wrought Ti-6Al-4V Alloy with Large Total Deformation: Physical Modeling and Verification by Rolling
Authors: Wojtaszek Marek , Korpała Grzegorz , Śleboda Tomasz , Zyguła Krystian , Prahl Ulrich
Published: September 2020

The influence of the total deformation amount on the microstructure and selected properties of Ti-6Al-4V alloy was determined in this study. Multi-axis compression tests on the MaxStrain module were performed to obtain large strains. Starting material for the research was obtained by the powder metallurgy (PM) route. Plastically processed cast alloy of the same chemical composition as PM alloy was also tested as reference material. The tests were performed with the cooling of samples between successive deformation stages, which allowed for the simulation of the temperature drop occurring during industrial processes. The multi-stage deformation ability of PM Ti-6Al-4V alloy without decohesion was confirmed. It has also been shown that the application of increasing total strain at a controlled temperature changes the samples resulting in the refinement of the microstructure and leads to the fragmentation of lamellae. The results obtained from MaxStrain tests were verified by multi-stage hot-rolling tests. Defect-free products were obtained, whose good quality was confirmed by the microstructural observations as well as by the investigations of their properties. The results of the rolling tests confirmed the possibility of hot processing of Ti-6Al-4V alloy compacts in industrial conditions, applying large total strain.
Surgical treatment of primary pulmonary artery sarcoma
Authors: Han Yongxin , Zhen Yanan , Liu Xiaopeng , Zheng Xia , Zhang Jianbin , Zhai Zhenguo , Duan Jun , Zhang Yajun , Liu Peng
Published: September 2020

Objective

Primary pulmonary artery sarcoma (PAS) is a rare tumor that originates from the intimal layer of the pulmonary artery or pulmonary valve and has a poor prognosis. The standard treatment for this devastating disease remains unclear. This study aimed to summarize the current standard treatments for PAS.

Methods

From September 2015 to January 2020, six patients were diagnosed with PAS and underwent pulmonary endarterectomy (PEA) at our department. Their medical records were retrospectively reviewed to analyze the clinical characteristics, histopathological features, and postoperative outcomes. Fourteen articles, each reporting at least 6 cases, identified 201 patients diagnosed with PAS, and 158 patients had detailed treatments and follow-up data.

Results

All of the patients who successfully underwent PEA were alive at follow-up, with a mean survival duration of 11.6 months (7–28 months), and one patient developed recurrence in the right upper lobe lung. Two patients received postoperative chemotherapy. In one patient, the tumor invaded the pulmonary valve.

Conclusions

PAS resection combined with PEA via the aid of cardiopulmonary bypass and deep hypothermic circulatory arrest could achieve maximal tumor resection in patients without metastatic lesions. An individualized surgery strategy relies on a precise preoperative imaging examination. Moreover, postoperative adjuvant therapy could yield improved survival outcomes.
Usefulness of prototypes in conceptual design: students’ view
Authors: Carfagni Monica , Fiorineschi Lorenzo , Furferi Rocco , Governi Lapo , Rotini Federico
Published: September 2020

Planning prototyping strategies for conceptual design purposes is a crucial activity, which needs a clear understanding of the potentialities of the different typologies of prototype. Therefore, to prepare future designers, it is very important to provide the required information in design-related academic courses. However, prototypes and prototyping activities are often taught in specific courses with a major emphasis on the underpinning technologies, but with limited attention on design implications, especially about the fuzzy-front-end of the design process. The work presented in this paper aims at investigating about how students perceive the usefulness of prototypes during conceptual design activities, in order to provide first indications about the gap to be filled. To this purpose, two classes of students participated to an experimental session, and were asked to perform a conceptual design task individually. Subsequently, they participated to an on-line survey developed to gather information about the perceived usefulness of prototypes, in relation to the performed conceptual design activity. Several findings have been obtained from this work, but maybe the most impacting one concerns the different consideration that the two samples of students had about the fidelity of prototypes. Indeed, differently from what recently highlighted in current literature, it emerged that engineering students preferred low-fidelity prototypes. However, other unexpected evidences have been found, which highlight that at least for the considered institution, students still lack a comprehensive understanding of the design-related potentialities of prototypes.
Noninvasive 7 tesla MRI of fatal craniocerebral gunshots – a glance into the future of radiologic wound ballistics
Authors: Gascho Dominic , Deininger-Czermak Eva , Zoelch Niklaus , Tappero Carlo , Sommer Stefan , Hinterholzer Natalie , Thali Michael J
Published: September 2020

Compared to computed tomography (CT), magnetic resonance imaging (MRI) provides superior visualization of the soft tissue. Recently, the first 7 Tesla (7 T) MRI scanner was approved for clinical use, which will facilitate access to these ultra-high-field MRI scanners for noninvasive examinations and scientific studies on decedents. 7 T MRI has the potential to provide a higher signal-to-noise ratio (SNR), a characteristic that can be directly exploited to improve image quality and invest in attempts to increase resolution. Therefore, evaluating the diagnostic potential of 7 T MRI for forensic purposes, such as assessments of fatal gunshot wounds, was deemed essential. In this article, we present radiologic findings obtained for craniocerebral gunshot wounds in three decedents. The decedents were submitted to MRI examinations using a 7 T MRI scanner that has been approved for clinical use and a clinical 3 T MRI scanner for comparison. We focused on detecting tiny injuries beyond the wound tract caused by temporary cavitation, such as microbleeds. Additionally, 7 T T2-weighted MRI highlighted a dark (hypo intense) zone beyond the permanent wound tract, which was attributed to increased amounts of paramagnetic blood components in damaged tissue. Microbleeds were also detected adjacent to the wound tract in the white matter on 7 T MRI. Based on the findings of radiologic assessments, the advantages and disadvantages of postmortem 7 T MRI compared to 3 T MRI are discussed with regard to investigations of craniocerebral gunshot wounds as well as the potential role of 7 T MRI in the future of forensic science.
Epidemiological and Clinical Patterns of Newly Diagnosed Hepatocellular Carcinoma in Brazil: the Need for Liver Disease Screening Programs Based on Real-World Data
Authors: Fernandes Gustavo dos Santos , Campos Daniel , Ballalai Andre , Palhares Rodrigo , da Silva Mario R. A. , Palhares Daniel M. F. , Neto Ben-Hur F. , Barros Fabio M. do R. , Gil Roberto de A. , Chagas Aline , Carrilho Flair José
Published: September 2020

Purpose

Describe sociodemographic and clinical characteristics of patients with hepatocellular carcinoma (HCC) and establish their history in the Brazilian public health system.

Methods

Retrospective observational study was conducted using the database from the Department of Informatics of the Unified Health System (DataSUS). Patients with at least one claim of HCC between July/2011 and June/2016 were included. A record linkage methodology was performed to obtain longitudinal data across different databases. Demographic and clinical data were evaluated, including the time elapsed between diagnosis of HCC risk-factors and the cancer development. Data was analyzed using descriptive statistics.

Results

A total of 28,822 HCC cases were identified between July/2011 and June/2016. Mean age was 59.7 years (SD = 14.7), and most patients were men (55.9%). The highest relative number of HCC cases was detected in the south of Brazil (> 20 cases/100,000 inhabitants). About 86.5% of the patients had diagnosis of HCC without previous liver diseases. Only 8% had diagnosis of chronic viral hepatitis and 3.5% cirrhosis. About 76% were diagnosed at an advanced stage, and only 11% of the patients had early stage HCC. Approximately 58% of patients with previous underlying liver diseases were diagnosed at early stages, compared with only 24% of patients without prior record of underlying diseases.

Conclusion

The diagnosis of HCC in the Brazilian public health is usually made in patients with no previous diagnosis of liver disease and in advanced stages, when no curative treatment is available and survival rates are low. Public health policies are key for the screening and monitoring liver disease and, consequently, HCC.
The Aporia of Future Directed Beliefs
Authors: Rönnedal Daniel
Published: September 2020

This paper discusses a new aporia, the aporia of future directed beliefs. This aporia contains three propositions: (1) It is possible that there is someone who is infallible that believes something about the future that is not historically settled, (2) it is necessary that someone is infallible if and only if it is necessary that everything she believes is true, and (3) it is necessary that all our beliefs are historically settled. Every claim in this set is intuitively plausible, and there are interesting arguments for or against each of them. Nevertheless, {(1), (2), (3)} entails a contradiction. Consequently, at least one of the sentences in this set must be false. I consider some possible solutions to the problem and discuss some arguments for and against these solutions. Five solutions, in particular, stand out. Three solutions reject (1), one solution rejects (2), and one solution rejects (3). No solution is without problems, and it is not obvious which one we should choose. Yet, we have to give up at least one sentence in {(1), (2), (3)}. This is the nature of an aporia.