bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Net Profit Margin (NPM), Return On Asset (ROA) Dan Current Ratio (CR) Terhadap Dividen Payout Ratio (DPR) Industri Manufaktur Sub Sektor Plastik Dan Kemasan Di Bursa Efek Indonesia (BEI) Tahun 2017-2020
Authors: Siburian Monika Vio Lista , Sembiring Destiana Fitriyani , Tambunan Putri Yohana Natasya , Bangun Sri Masita , Helman Helman , Hasibuan Lailan Safina
Published: June 2024

Tujuan dari diadakannya penelitian ini adalah untuk melihat Pengaruh Net Profit Margin (NPM), Return On Asset (ROA) dan Current Ratio (CR). Terhadap Dividen Payout Ratio (DPR) Industri Manufaktur Sektor Plastik dan Kemasaan di Bursa Efek Indonesia (BEI) Tahun 2017-2020. Jenis penelitian yang digunakan untuk penelitian ini adalah penelitian kuantitatif, sumber data dalam penelitian ini adalah penelitian sekunder. Populasi penelitian ini diperoleh 14 perusahaan yang masuk dalam kriteria terdaftar, 3 perusahaan yang tidak mempublikasikan secara rutin selama periode penelitian, 5 perusahaan yang tidak memperoleh laba bersih selama periode penelitian, dan perusahaan terdaftar dikurangi dengan perusahaan tidak terdaftar, dan dikurangi dengan perusahaan yang tidak memperoleh laba bersih hasilnya adalah 6 dan dikalikan 4 tahun menjadi 24. Teknik pengumpulan data yang digunakan dalam penelitian ini menggunakan teknik dokumentasi mengumpulkan data sekunder dari laporan keuangan tahunan subsektor plastik dan kemasan tahun 2017-2020 berdasarkan hasil penelitian ini secara parsial dan simultan bahwa variable x Net Profit Margin (NPM), Return On Asset (ROA), dan Current Ratio (CR) pengaruh signifikan pada variabel y Divident Payout Ratio (DPR). Hasil koefisien determinasi menunjukkan variabel- variabel independen (X) mempengaruhi variabel devenden (Y) dalam penelitian ini sebesar 47 % sedangkan 53% lainnya terpengaruh oleh variabel atau factor lain diluar penelitian.
Pengaruh Return On Assets, Return On Equity, Earning Per Share, Dan Debt To Equity Ratio Terhadap Harga Saham
Authors: Tunisa Ikhda Choeru , Suwarno Agus Endro
Published: June 2024

The purpose of this study is to determine the influence of Return On Assets, Return On Equity, Earning Per Share, and Debt To Equity Ratio on stock prices in companies listed on the Indonesia Stock Exchange (IDX) from 2020 to 2022. The sampling method employed in this research is purposive sampling technique, resulting in a sample size of 111 companies over 3 years. Secondary data was utilized and processed using SPSS. The findings of the research indicate that Return On Assets has no significant effect on stock prices, Return On Equity has no significant effect on stock prices, Earning Per Share has a significant effect on stock prices, and Debt To Equity Ratio has no significant effect on stock prices.
Pengaruh Motivasi, Kompetensi, dan Gaya Kepemimpinan Terhadap Kinerja Prajurit Bekangdam IV/Diponegoro
Authors: Ambarwanto Dimas Aditya , Kasmari Kasmari
Published: June 2024

This research aims to determine the influence of motivation, competence and leadership style on the performance of Bekangdam IV/Diponegoro Soldiers. The method used is quantitative with a type of field research. Through the accidental sampling technique, a sample of 72 soldiers was obtained. The data sources for this research are divided into primary data sources in the form of questionnaires and secondary data sources, namely documents in the form of additional data during the research.  Data was collected through observation, documentation and questionnaires which became research instruments. Data was collected and then analyzed through multiple linear regression analysis and hypothesis testing. The results of the research state that Motivation, competency, and leadership style have a positive and significant effect on the performance of Bekangdam IV/Diponegoro Soldiers.  The leadership style applied by the leader is a motivational type.
PENERAPAN MODEL PEMBELAJARAN CREATIVE PROBLEM SOLVING DALAM MENINGKATKAN HASIL BELAJAR KOGNITIF SISWA KELAS XI SMAN 1 KUBU PADA MATERI SIFAT ELASTISITAS BAHAN
Authors: Nurasyiah Nurasyiah , Yennita Yennita , Syahril Syahril
Published: June 2024

Penelitian ini bertujuan untuk mendeskripsikan hasil belajar kognitif siswa dengan model pembelajaran menggunakan model pembelajaran creative problem solving pada materi Sifat Elastisitas Bahan  dan untuk Mengetahui hasil belajar kognitif siswa antara yang menggunakan model pembelajaran creative problem solving pada materi Sifat Elastisitas Bahan kelas XI SMA Negeri 1 Kubu dengan kelas yang menerapkan pembelajaran konvensional. Penelitian dilakukan terhadap peserta didik kelas XI SMA Negeri 1 Kubu pada materi sifat elastisitas bahan, kelas yang diambil yaitu kelas XI IPA 2 yang berjumlah 28 peserta didik dan kelas XI IPA 1  yang berjumlah 33 siswa dimana kedua kelas tersebut terdiri dari kelas eksperimen dan kelas kontrol. Instrument pengumpulan data berupa tes hasil postes pemahaman konsep pada materi sifat elastisitas bahan  kelas XI SMA yang terdiri dari 12 soal objektif. Jenis penelitian yang digunakan pada penelitian ini adalah quasi experiment (eksperimen semu) dan desain penelitian yang digunakan pada penelitian ini yaitu Posttest Only Control Group Design. Jenis penelitiannya adalah quasi eskperimen dengan desain Posstest Only Non-equivalen Kontrol Group Design. Uji independent sample t-test dengan bantuan SPSS versi 21 menunjukkan bahwa model pembelajaran creative problem solving berpengaruh terhadap belajar kognitif siswa. Kemampuan hasil belajar kognitif siswa kelas eksperimen lebih baik dibandingkan kelas kontrol. Selanjutnya, nilai rata-rata kelas eksperimen sebesar 81,85 dan kelas kontrol sebesar 73,48. Hasil ini menunjukkan bahwa model pembelajaran creative problem solving efektif terhadap hasil belajar kognitif siswa.
The Benefits of insects as a nutrient
Authors: Younes Samer
Published: June 2024

The global population is growing at an alarming rate, leading to a shortage of land and food resources. As a result, there is a need to find alternative sources of food. Edible insects have gained significant attention due to their economic and environmental benefits, as well as their potential in various industries. The consumption of edible insects is not limited to India but is prevalent worldwide. These insects are highly nutritious, containing high levels of fat, protein, and micronutrients that vary among different species. Therefore, they offer a valuable solution to address the food needs of future generations. The demand for alternative protein-rich foods is rapidly increasing globally, and insects present an innovative and sustainable option as a feed source. In addition to protein, insects also provide essential nutrients such as fats, minerals, and vitamins. This paper aims to explore the different types of edible insects and their nutritional value.
South African flag sign: A Red Flag in ECG
Authors: Mandal Amit
Published: June 2024

A method is developed to allow cardiologists to find changes in the blood flow rate in larger coronary arteries, caused by the appearance of their pathological tortuosity, and a hemodynamic significance of those changes based on the data taken from the appropriate coronarographies only. This method is based on replacement of blood flows in the originally healthy and subsequently pathologically tortuous artery with the corresponding averaged ones, and subsequent calculation of flow characteristics of interest in terms of the corresponding averaged flow characteristics. It allows one not to take account of a number of identical factors for the originally healthy and subsequently pathologically tortuous segment of the investigated artery, and gives one the possibility to determine the flow parameters of concern at any time after carrying out a coronarography. In addition, it is not associated with solving complicated technical problems, and does not require special facility to be used, special professional training and significant financial and temporal expenses. The method was successfully tested in-vitro and then applied to appropriate patients. It was found that the hemodynamic significance of the tortuosity generally increases/decreases as the number of the tortuosity arcs increases/decreases. Also, strong correlation between fundamental geometric and hemodynamic characteristics of the tortuosity and basic clinical indicators of the corresponding patients was established. This suggests a strong independent influence of the tortuosity on the clinical symptoms of the corresponding patients. The critical values for the number of the tortuosity arcs, the relative blood flow rate loss and the rate of angina.
Our First Experience with Transplantation – A Case Report
Authors: Falica Dorotea
Published: June 2024

Goal: Transplantation is the medical procedure of transplanting an organ from a living or deceased person into the body of a recipient whose organ is severely and irreversibly damaged. In this way, the recipient's survival rate and quality of life are improved. Heart transplantation is a revolutionary procedure that provides a new chance for life to patients with serious heart diseases. It represents a great challenge both for the patient and for the entire healthcare system. We aim to provide a comprehensive account of our first heart transplant experience. Through a detailed analysis of the case report, we will present the challenges we encountered, the successes we achieved, and provide a deeper insight into the entire process of heart transplantation from the perspective of nurses.
New species of plume moths (Lepidoptera: Pterophoridae) from Ecuador. Part 2
Authors: Kovtunovich V.N. , Ustjuzhanin P.Ya.
Published: June 2024

Five new species of plume moths (Lepidoptera: Pterophoridae) are described from Ecuador: Platyptilia azuayensis sp. nov., Hellinsia juliae sp. nov., H. razboinikovi sp. nov., H. muratovi sp. nov., and H. elini sp. nov. Two species of Pterophoridae, Quadriptilia obscurodactyla Gielis, 1994 and Stenoptilodes brevipennis (Zeller, 1874), are recorded from Ecuador for the first time.
Modelling of Multicomponent Fluid Flow in Deforming and Reacting Porous Rock
Authors: Khakimova L. A. , Podladchikov Y. Y.
Published: June 2024

We propose a coupled hydro-chemo-mechanical model and its 1D numerical implementation. We demonstrate its application to model filtration of a multicomponent fluid in deforming and reacting host rocks, considering changes in the densities, phase proportions and chemical compositions of coexisting phases. We presented 1D numerical implementation on the example of soapstone formation from serpentinite during H₂O-СО2 fluid filtration with low concentration of СО2 coupled with viscous deformation of mineral matrix, considering MgO-SiO2-H₂O-СО2 system. The numerical results show porosity wave propagation by viscous (de)compaction mechanism accompanied with the formation of an elongated zone with higher filtration properties. After the formation of such a channel, the formation and propagation of reaction fronts occurs associated with the transformation of the mineral composition of the original rock. During H2O-CO2 fluid filtration, starting from 1 weight percent of dissolved CO2, carbonization of hydrated serpentinite starts, specifically antigorite transforms to magnesite and talc.
Clorine Solubility in Silicate Melts: New Experiments and Thermodynamic Mixing Model
Authors: Aranovich L. Y. , Golunova M. A. , Connolly J.A. D. , Ivanov M. V.
Published: June 2024

We present new experimental data on Cl solubility in model basalt melts of eutectic compositions diopside (Di)–albite (Ab) and Di–anorthite ± quartz (Qtz). The starting glasses were equilibrated with aqueous fluid H₂O-NaCl-CaCl₂ at 4 kbar in the temperature range 900–1200°C. The experiments show that the Cl solubility decreases with increasing NaCl in the fluid. Ca-Na partitioning between melts and fluid is weekly temperature dependent and resembles that of the plagioclase-fluid system. The new experimental data, along with the previously published results on the model granite melting in the presence of (Na, K)Cl brines (Aranovich et al., 2013) are used to calibrate an empirical thermodynamic model for the salt species (NaCl, KCl, CaCl₂) in silicate melt. Calculations show that Cl solubility in the haplogranite melt decreases with increasing K/Na ratio in the fluid (and, correspondingly, melt). At high pressure (10 kbar) Cl solubility in the granite increases with increasing H₂O content. Calculated phase diagram for a simple pseudo-ternary system Ab–H₂O–NaCl demonstrates complex phase relations and, correspondingly, evolution of the H₂O and NaCl concentrations in the melt. Literature data on the variations of H₂O and NaCl in the melt and fluid inclusions in Qtz from the granite of Badzhal tin deposit is used to illustrate complex evolution of a fluid-magmatic system.
Cervical ganglioneuroma as a rare cause of cervicogenic headache: A case report and literature review
Authors: Park Eunjin , Lee Yeon Soo , Yi Jin-Seok , Choi Eunseok
Published: June 2024

BACKGROUND: Cervicogenic headache is characterized by chronic posterior neck pain radiating to one side of the head, resulting from cervical spine bone or soft tissue diseases. Cervical ganglioneuroma (GN), a rare benign neuroblastic tumor, especially in the cervical spine, may cause cervicogenic headache-like symptoms. OBJECTIVE: We report a case of GN which was surgically removed successfully to relieve the symptom. CASE REPORT: A 68-year-old male presented with right posterior neck pain with referred pain to the ipsilateral occipital area in May 2020. Despite administration of medications, physical therapy, and spine interventions, the symptoms intermittently recurred over one year. In July 2021, the patient complained of painful limitation of neck motion, especially on right-sided bending; no motor or sensory deficits, except for subjective numbness of the finger tips, were detected. Plain radiography of the cervical spine showed moderate degenerative changes in the mid-cervical spine. Cervical MRI revealed a cystic mass (1.5 cm × 0.5 cm × 1 cm-in size) around the right C2 dorsal root ganglion adjacent to the C1–C2 facet joint. His symptoms significantly improved after complete tumor excision. CONCLUSION: GN of the upper cervical spine should be considered when persistent cervicogenic headache is refractory to conservative management. In such a case, advanced imaging studies such as MRI should be performed for early diagnosis and appropriate treatment.
Products ranking through two-stage online customer reviews information
Authors: Liu Shi-Tong , Liu Yong , Ding Jia-Ming
Published: June 2024

In the process of product ranking considering online reviews, they often are based on initial reviews and do not consider additional consumer reviews, but additional review information can sometimes directly affect consumers’ final decisions. To fully characterize the rich emotional preferences of consumers embedded in two-stage online customer reviews information, considering consumers’ individual preferences and product objective evaluation information, we construct a combination weighting method to calculate comprehensive weights of product attributes, and then exploit the sentiment analysis technique, interval-valued probabilistic linguistic term set (IVPLTS) and preference ranking organization method for enrichment evaluations (PROMETHEE) to establish a products ranking method based on compound reviews, and then we use it to identify the sentiment orientation of reviews and the results. Finally, a real-life case illustrates a real-world application of the proposed method.
Examining the interdependencies of e-government challenges using PESTELMO, DEMATEL and ANP: A case study of Tanzania
Authors: Mkude Catherine G. , Peter Michael
Published: June 2024

E-government transformation requires a deeper understanding of contextual factors, including prevailing challenges. Significantly, few studies have raised that e-government challenges are not independent and that their interdependencies warrant further investigations. This study aims to analyse the interdependencies of e-government challenges using qualitative and quantitative methods – PESTELMO (Political, Economic, Socio-cultural, Technological, Environmental, Legal, Managerial and Organisational) analysis method and DEMATEL (Decision-Making Trial and Evaluation Laboratory) and ANP (Analytic Network Process) respectively. PESTELMO analysis method categorised 27 e-government challenges in Tanzania, which were then subjected to DEMATEL. DEMATEL results show that net causes are political, economic and legal challenges, while net receivers are sociocultural, technological, environmental, managerial and organisational challenges. The ANP results reveal that economic challenges are the most significant among the net causes. Hence, e-government policy and strategy makers may want to prioritise economic challenges to propagate beneficial results. This is the first study that analyses, visualises and attempts to measure the interdependencies among e-government challenges in Tanzania. The contributions of this paper lie in the empirical analysis of e-government challenges. The results provide insights to practitioners and researchers of e-government in Tanzania on the most critical challenges/hurdles to focus on for successful e-government transformation.
Dementia Ideal Care: Ecosystem Map of Best Practices and Care Pathways Enhanced by Technology and Community
Authors: Dombrowski Wen , Mims Adrienne , Kremer Ian , Cano Desandes Pedro , Rodrigo-Herrero Silvia , Epps Fayron , Snow Teepa , Gutierrez Myrna , Nasta Anil , Epperly Mikele Bunce , Manaloto Katrina , Hansen Jennie Chin
Published: June 2024

Background: Globally, much work has been done by nonprofit, private, and academic groups to develop best practices for the care of people living with dementia (PLWD), including Alzheimer’s disease. However, these best practices reside in disparate repositories and tend to focus on one phase of the patient journey or one relevant group. Objective: To fill this gap, we developed a Dementia Ideal Care Map that everyone in the dementia ecosystem can use as an actionable tool for awareness, policy development, funding, research, training, service delivery, and technology design. The intended audience includes (and not limited to) policymakers, academia, industry, technology developers, health system leaders, clinicians, social service providers, patient advocates, PLWD, their families, and communities at large. Methods: A search was conducted for published dementia care best practices and quality measures, which were then summarized in a visual diagram. The draft diagram was analyzed to identify barriers to ideal care. Then, additional processes, services, technologies, and quality measures to overcome those challenges were brainstormed. Feedback was then obtained from experts. Results: The Dementia Ideal Care Map summarizes the ecosystem of over 200 best practices, nearly 100 technology enablers, other infrastructure, and enhanced care pathways in one comprehensive diagram. It includes psychosocial interventions, care partner support, community-based organizations; awareness, risk reduction; initial detection, diagnosis, ongoing medical care; governments, payers, health systems, businesses, data, research, and training. Conclusions: Dementia Ideal Care Map is a practical tool for planning and coordinating dementia care. This visualized ecosystem approach can be applied to other conditions.
Cerebrospinal Fluid Proteomics Identifies Potential Biomarkers for Early-Onset Alzheimer’s Disease
Authors: Li Dazhi , Xie Qiang , Xie Jikui , Ni Ming , Wang Jinliang , Gao Yuru , Wang Yaxin , Tang Qiqiang
Published: June 2024

Background: Early-onset Alzheimer’s disease (EOAD) exhibits a notable degree of heterogeneity as compared to late-onset Alzheimer’s disease (LOAD). The proteins and pathways contributing to the pathophysiology of EOAD still need to be completed and elucidated. Objective: Using correlation network analysis and machine learning to analyze cerebrospinal fluid (CSF) proteomics data to identify potential biomarkers and pathways associated with EOAD. Methods: We employed mass spectrometry to conduct CSF proteomic analysis using the data-independent acquisition method in a Chinese cohort of 139 CSF samples, including 40 individuals with normal cognition (CN), 61 patients with EOAD, and 38 patients with LOAD. Correlation network analysis of differentially expressed proteins was performed to identify EOAD-associated pathways. Machine learning assisted in identifying crucial proteins differentiating EOAD. We validated the results in an Western cohort and examined the proteins expression by enzyme-linked immunosorbent assay (ELISA) in additional 9 EOAD, 9 LOAD, and 9 CN samples from our cohort. Results: We quantified 2,168 CSF proteins. Following adjustment for age and sex, EOAD exhibited a significantly greater number of differentially expressed proteins than LOAD compared to CN. Additionally, our data indicates that EOAD may exhibit more pronounced synaptic dysfunction than LOAD. Three potential biomarkers for EOAD were identified: SH3BGRL3, LRP8, and LY6 H, of which SH3BGRL3 also accurately classified EOAD in the Western cohort. LY6 H reduction was confirmed via ELISA, which was consistent with our proteomic results Conclusions: This study provides a comprehensive profile of the CSF proteome in EOAD and identifies three potential EOAD biomarker proteins.
The Anti-Neuroinflammatory Effect of Extra-Virgin Olive Oil in the Triple Transgenic Mouse Model of Alzheimer’s Disease
Authors: Li Jian-Guo , Mutreja Yamini , Servili Maurizio , Leone Alessandro , Praticò Domenico
Published: June 2024

Background: Chronic intake of extra virgin olive oil is beneficial for brain health and protects from age-related cognitive decline and dementia, whose most common clinical manifestation is Alzheimer’s disease. Besides the classical pathologic deposits of amyloid beta peptides and phosphorylated tau proteins, another frequent feature of the Alzheimer’s brain is neuroinflammation. Objective: In the current study, we assessed the effect that extra virgin olive oil has on neuroinflammation when administered to a mouse model of the disease. Methods: Triple transgenic mice were randomized to receive a diet enriched with extra virgin olive oil or regular diet for 8 weeks. At the end of this treatment period the expression level of several inflammatory biomarkers was assessed in the central nervous system. Results: Among the 79 biomarkers measured, compared with the control group, mice receiving the extra virgin olive oil had a significant reduction in MIP-2, IL-17E, IL-23, and IL-12p70, but an increase in IL-5. To validate these results, specific ELISA kits were used for each of them. Confirmatory results were obtained for MIP-2, IL-17E, IL-23, and IL-12-p70. No significant differences between the two groups were observed for IL-5. Conclusions: Our results demonstrate that chronic administration of extra virgin olive oil has a potent anti-neuroinflammatory action in a model of Alzheimer’s disease. They provide additional pre-clinical support and novel mechanistic insights for the beneficial effect that this dietary intervention has on brain health and dementia.
Disease Progression of Data-Driven Subtypes of Parkinson’s Disease: 5-Year Longitudinal Study from the Early Parkinson’s Disease Longitudinal Singapore (PALS) Cohort
Authors: Deng Xiao , Saffari Seyed Ehsan , Xiao Bin , Ng Samuel Yong Ern , Chia Nicole , Choi Xinyi , Heng Dede Liana , Ng Ebonne , Xu Zheyu , Tay Kay-Yaw , Au Wing-Lok , Tan Eng-King , Tan Louis C.S.
Published: June 2024

Background:

The detailed trajectory of data-driven subtypes in Parkinson’s disease (PD) within Asian cohorts remains undisclosed.

Objective:

To evaluate the motor, non-motor symptom (NMS) progression among the data-driven PD clusters.

Methods:

In this 5-year longitudinal study, NMS scale (NMSS), Hospital Anxiety Depression Scale (HADS), and Epworth sleepiness scale (ESS) were carried out annually to monitor NMS progression. H& Y staging scale, MDS-UPDRS part III motor score, and postural instability gait difficulty (PIGD) score were assessed annually to evaluate disease severity and motor progression. Five cognitive standardized scores were used to assess detailed cognitive progression. Linear mixed model was performed to assess the annual progression rates of the longitudinal outcomes.

Results:

Two hundred and six early PD patients, consisting of 43 patients in cluster A, 98 patients in cluster B and 65 subjects in cluster C. Cluster A (severe subtype) had significantly faster progression slope in NMSS Domain 3 (mood/apathy) score ( p = 0.01), NMSS Domain 4 (perceptual problems) score ( p = 0.02), NMSS Domain 7 (urinary) score ( p = 0.03), and ESS Total Score ( p = 0.04) than the other two clusters. Cluster A also progressed significantly in PIGD score ( p = 0.04). For cognitive outcomes, cluster A deteriorated significantly in visuospatial domain ( p = 0.002), while cluster C (mild subtype) deteriorated significantly in executive domain ( p = 0.04).

Conclusions:

The severe cluster had significantly faster progression, particularly in mood and perceptual NMS domains, visuospatial cognitive performances, and postural instability gait scores. Our findings will be helpful for clinicians to stratify and pre-emptively manage PD patients by developing intervention strategies to counter the progression of these domains.
Gait Analysis with Wearable Sensors in Isolated REM Sleep Behavior Disorder Associated with Phenoconversion: An Explorative Study
Authors: Cen Shanshan , Zhang Hui , Li Yuan , Gu Zhuqin , Yuan Yuan , Ruan Zheng , Cai Yanning , Chhetri Jagadish K. , Liu Shuying , Mao Wei , Chan Piu
Published: June 2024

Background:

Gait disturbance is a vital characteristic of motor manifestation in α– synucleinopathies, especially Parkinson’s disease. Subtle gait alterations are present in isolated rapid eye movement sleep behavior disorder (iRBD) patients before phenoconversion; it is yet unclear, if gait analysis may predict phenoconversion.

Objective:

To investigate subtle gait alterations and explore whether gait analysis using wearable sensors is associated with phenoconversion of iRBD to α-synucleinopathies.

Methods:

Thirty-one polysomnography-confirmed iRBD patients and 33 healthy controls (HCs) were enrolled at baseline. All participants walked for a minute while wearing 6 inertial sensors on bilateral wrists, ankles, and the trunk (sternal and lumbar region). Three conditions were tested: (i) normal walking, (ii) fast walking, and (iii) dual-task walking.

Results:

Decreased arm range of motion and increased gait variation (stride length, stride time and stride velocity) discriminate converters from HCs at baseline. After an average of 5.40 years of follow-up, 10 patients converted to neurodegenerative diseases (converters). Cox regression analysis showed higher value of stride length asymmetry under normal walking condition to be associated with an early conversion of iRBD to α– synucleinopathies (adjusted HR 4.468, 95% CI 1.088– 18.349, p = 0.038).

Conclusions:

Stride length asymmetry is associated with progression to α– synucleinopathies in patients with iRBD. Gait analysis with wearable sensors may be useful for screening, monitoring, and risk stratification for disease-modifying therapy trials in patients with iRBD.
Use and acceptance of technologies in the German measure supported employment
Authors: Winkelkotte Frederik , Baumann Lukas , Grengel Michelle , Jochmaring Jan , York Jana
Published: June 2024

BACKGROUND: The measure Supported Employment (SE) and digitalization offer people with disabilities increased opportunities for participation in working life. Different technology acceptance models such as the TAM or UTAUT indicate that whether a technology is used or not crucially depends on various factors such as the perceived usefulness or perceived ease of use of a technology. OBJECTIVE: This study aims to investigate factors influencing the acceptance of digital technologies in the measure SE. Risks and opportunities for people with disabilities are examined. METHODS: The data basis consists of 16 qualitative guided interviews with job coaches and clients. The data evaluation is carried out by means of qualitative content analysis. RESULTS: In line with the TAM and the UTAUT, six main factors could be identified as relevant for the acceptance of digital technologies in the measure SE: perceived usefulness, perceived ease of use, attitudes toward using, social influence, facilitating conditions, and individual factors seem to influence the actual use of technologies. The interviews show opportunities such as increased participation of people with disabilities in working life through technologies, but also risks such as the exclusion of older or less experienced people. CONCLUSION: Factors from technology acceptance research also apply in SE and must be recognized before introducing new technologies.
Analysis of kidney infection data using correlated compound poisson frailty models
Authors: Hanagal David D.
Published: June 2024

Shared frailty models are used despite their limitations. To overcome their disadvantages correlated frailty models may be used. In this paper, we introduce the correlated compound Poisson frailty models with two different baseline distributions namely, the generalized log logistic and the generalized Weibull. We introduce the Bayesian estimation procedure using Markov Chain Monte Carlo (MCMC) technique to estimate the parameters involved in these models. We present a simulation study to compare the true values of the parameters with the estimated values. Also we apply these models to a real life bivariate survival data set of McGilchrist and Aisbett (1991) related to the kidney infection data and a better model is suggested for the data.
Parametric analysis and model selection for economic evaluation of survival data
Authors: Nemes Szilárd
Published: June 2024

Health technology assessments of interventions impacting survival often require extrapolating current data to gain a better understanding of the interventions’ long-term benefits. Both a comprehensive examination of the trial data up to the maximum follow-up period and the fitting of parametric models are required for extrapolation. It is standard practice to visually compare the parametric curves to the Kaplan-Meier survival estimate (or comparison of hazard estimates) and to assess the parametric models using likelihood-based information criteria. In place of these two steps, this work demonstrates how to minimize the squared distance of parametric estimators to the Kaplan-Meier estimate. This is in line with the selection of the model using Mean Squared Error, with the modification that the unknown true survival is replaced by the Kaplan-Meier estimate. We would assure the internal validity of the extrapolated model and its appropriate representation of the data by adhering to this procedure. We use both simulation and real-world data with a scenario where no model that properly fits the data could be found to illustrate how this process can aid in model selection.
Application study of apnea-hypopnea duration for assessing adult obstructive sleep apnea
Authors: Cheng Weigen , Xu Cheng , Wang Fen , Ding Yongmin , Tu Jianglong , Xia Linglin
Published: June 2024

BACKGROUND: Obstructive sleep apnea (OSA) is a common sleep disordered breathing disorder, which can cause serious damage to multiple human systems. Although polysomnography (PSG) is the current gold standard for diagnosis, it is complex and expensive. Therefore, it is of great significance to find a simple, economical and rapid primary screening and diagnosis method to replace PSG for the diagnosis of OSA. OBJECTIVE: The purpose of this study is to propose a new method for the diagnosis and classification of OSA, which is used to automatically detect the duration of sleep apnea hypopnea events (AHE), so as to estimate the ratio(S) of the total duration of all-night AHE to the total sleep time only based on the sound signal of sleep respiration, and to identify OSA. METHODS: We performed PSG tests on participants and extracted relevant sleep breathing sound signal data. This study is carried out in two stages. In the first stage, the relevant PSG report data of eligible subjects were recorded, the total duration of AHE in each subject’s data was extracted, and the S value was calculated to evaluate the severity of OSA. In the second stage, only the sleep breath sound signal data of the same batch of subjects were used for automatic detection, and the S value in the sleep breath sound signal was extracted, and the S value was compared with the PSG diagnosis results to calculate the accuracy of the experimental method. RESULTS: Among 225 subjects. Using PSG as the reference standard, the S value extracted from the PSG diagnostic data report can accurately diagnose OSA(accuracy rate 99.56%) and distinguish its severity (accuracy rate 95.11%). The accuracy of the S value detected in the sleep breathing sound signal in the diagnosis of severe OSA reached 100%. CONCLUSION: The results show that the experimental parameter S value is feasible in OSA diagnosis and classification. OSA can be identified and evaluated only by sleep breathing sounds. This method helps to simplify the diagnostic grading of traditional OSA and lays a foundation for the subsequent development of simple diagnostic grading equipment.
What are the novel rehabilitation methods in knee arthroplasty? A bibliographic review
Authors: Kara Seher , Nokay Aziz Emre
Published: June 2024

BACKGROUND: Total knee arthroplasty (TKA) is a common procedure for treating end-stage degenerative knee osteoarthritis (OA). Despite the generally excellent outcomes, postoperative complications such as loss of muscle strength and joint limitation can occur. Therefore, postoperative physical rehabilitation is crucial for regaining strength, functionality, and managing pain. Various rehabilitation strategies employ different methods to reduce pain severity, regain muscle strength, assist patients in returning to daily activities, and increase functionality. In recent years, technological advancements have transformed rehabilitation methods. In addition to traditional applications, new methods have been incorporated into treatment plans. OBJECTIVE: This study aimed to evaluate novel physical rehabilitation methods and options following OA. METHODS: A literature review was conducted to identify and investigate recent and commonly used novel rehabilitation methods. The search terms “Total Knee Arthroplasty,” “New Rehabilitation TKA,” “Novel Rehabilitation” “Novel Rehabilitation in Arthroplasty” and “Technology Knee Rehabilitation” were searched across PubMed and Google Scholar databases, covering literature from the past 15 years. Studies on telerehabilitation, functional electric stimulation, virtual reality, yoga, and their reported outcomes were evaluated using specific keywords. The results of various studies on novel rehabilitation methods were gathered and compared to traditional treatment plans based on functionality and applicability. RESULTS: Several studies reported that telerehabilitation was not inferior to traditional rehabilitation, with some showing positive outcomes. Telerehabilitation following TKA demonstrated positive effects on functionality and patient satisfaction. Functional electric stimulation showed significant improvements in muscle strength and pain reduction. Virtual reality demonstrated superior effects on proprioception and posture outcomes. The use of yoga in rehabilitation also resulted in improved proprioception and pain reduction. CONCLUSION: In addition to traditional rehabilitation methods, new approaches have shown significant positive outcomes for patients who have received TKA. We are in an era of digital development, and as such, new rehabilitation techniques, particularly those involving digital advancements, will continue to emerge. With the trend toward personalized approaches in medicine, more new techniques or methods will be incorporated into rehabilitation plans, leading to better recovery outcomes from TKA.
Phyto-Therapeutic Potential and Pharmaceutical Impact of Shilajit (Asphaltum punjabianam): Current Research and Future Prospects
Authors: Qadir Abdul , Ali Athar , Singh Tanuja
Published: June 2024

Shilajit, derived from India, is a naturally-occurring mineral substance with a range of components, utilized in the medicinal practices of both Ayurveda and Siddha traditions.Shilajit has been employed for its phytomedicinal effects in addressing various ailments, as well as for nutritional purposes. Shilajit contains rich source of humic substances (like fulvic acid, humic acid), among the over 20 elements it contains are calcium, magnesium, sodium, iron, chromium, and lead. Additionally, it contains hydrocarbons, proteins, carbohydrates, fatty acids, amino acids, and alcohols. Furthermore, about 15-20% of minerals are also present. The diverse range of phytochemicals present in them imparts a more potent impact on human health, coupled with significant antioxidant capacity. Presently, it is being proposed as a potential source for various unique industrial and medicinal products. In literature, a wealth of data provided about geographical description, herb interaction, therapeutic intervention, nanotechnology on and combined approaches Formulation strategies. In this review, there is a comprehensive presentation of information encompassing the phytochemical significance, pharmacology, pharmaceutical impact, and the potential applications in nanotechnology, along with the nutraceutical values of shilajit.
Türk Sanatında Ördek İmgesi: Kültürel İkon veya Sembolik Anlam
Authors: Sezgin Özrili Ayşenur
Published: June 2024

Türk sanatında ördek sembolizminin, estetik ve görsel denemeleri genellikle ahşap, çini, maden, minyatür, seramik, taş, tekstil, vb. malzemelerle şekillendirilmiştir. Doğal dünyanın sevimli yansımaları olan ördekler, Türk sanatında doğa ile bağlantısı bulunan, dini, kültürel anlamları ile insanlarla olan ilişkilerinin sanatla buluştuğu özel canlılardır. Bu çalışma, Türk sanatında kullanılan ördek figürlerinin ikonlaşma serüvenini, hangi ikonografik mesajlar ihtiva ettiğini ve sanat eseri olma özelliklerinin teknik ve üslup pozisyonlarının incelenmesidir. Ördek sembolü, Türk sanatında geniş bir yelpazede görülen bir motif olup, resim, heykel, yazı ve diğer sanat formlarında karşımıza çıkmaktadır. Bu incelemede, ördeğin Türk topraklarındaki tarihî ve mitolojik kökenlerine değinilmektedir. Ördek imgesinin Türk sanatında geçmişten günümüze kadar olan süreçteki yeri ve yapım teknikleri üzerinde durulmaktadır. Aynı zamanda, birçok ikonografik mana ihtiva ederek Türk sanatında uzun bir geçmişe sahip olduğu ve çeşitli dönemlerde farklı şekillerde yorumlandığı görülmektedir. Bu makale, okuyuculara ördek imgesinin Türk kültüründeki yerini, sembolik anlamlarını ve sanat üzerindeki etkisini açıklamaktadır. Türk sanatının derinliklerine ve toplumsal değerlerine ışık tutmaktadır. Aynı zamanda, Türk mitolojisi, destanlar, halk hikâyeleri ve masallar gibi kültürel unsurlarla da bağlantılar kurarak, ördek imgesinin çok boyutlu bir anlam taşıdığını göstermektedir. Türk sanatıyla ilgilenen araştırmacılar, sanatseverler ve Türk kültürünü ve sanatını daha iyi anlamak isteyenler için değerli bir kaynak niteliği taşıyabilir.
Geleneksel Türk Sanatında Keseler (Kayseri İli Örneği)
Authors: Özkan Kuş Nurhan , Çelik Derya , Kılınç Nurgul
Published: June 2024

Türk kültüründe günlük yaşamda; içinde para, altın, gümüş, tütün, mühür, saat, baharat, cüz gibi nesneleri taşımak, aynı zamanda giysileri süslemek için kullanılan el işi keseler bu araştırmanın konusunu oluşturmaktadır. Araştırmada, geleneksel Türk sanatları içinde önemli bir yere sahip, maddi kültür değerlerinden olan el işi keselerinin kullanım amacı, boyut, malzeme, renk, desen, motif vb. teknik ve tasarım özelliklerini belirlemek amaçlanmıştır. Araştırmanın modeli nitel araştırma yöntemlerinden, etnoğrafik modeldir. Araştırmada saha çalışması yapılmıştır. Araştırma kapsamında, Kayseri Etnografya Müzesi’nde bulunan 13 adet para, 9 adet tütün, 1 adet mühür ve 2 adet saat kesesinden oluşan toplam 25 adet kese örneği incelenmiştir. Keselerin fotoğrafları çekilerek ölçüleri alınmış, tasarım ve teknik özellikleri gözlem formlarına kaydedilmiştir. Gözlem formlarının doldurulmasında envanter kayıtlarından da yararlanılmıştır. Araştırma sonucunda, para keselerinin genellikle tığ ile örüldüğü, tütün keselerinin kumaşa uygulandığı, saat keselerinin ise boncuk örme ve tığ ile örme teknikleri ile yapıldığı, keselerin süslemesinde, bitkisel, geometrik, figürlü, nesneli motifli kompozisyonlar uygulandığı tespit edilmiştir. Araştırmanın, kültür değerlerimizden olan hem estetik hem de işlevsel özellikleri ile dikkat çeken keselerin özelliklerinin belirlenmesi, tasarım ve teknik özellikleri ile tasarımcılara esin kaynağı olması açısından önemli olduğu düşünülmektedir.
Harezm Kültüründe Kutsal Koku ve Duman: Tütsü
Authors: Çam Esra
Published: June 2024

Ateşin keşfinden sonra doğada bulunan reçineler, otlar, ağaç kabukları, baharatlar gibi daha pek çok maddenin insan tarafından ateşle birleştirildiği ve bu keşfin akabinde mistik anlamlar yüklenerek ritüellerde kullanılmaya başlandığı ifade edilebilir. Tütsü, güzel koku elde etmenin ve odaklanma sağlamanın çok daha ötesinde Tanrı ile insan arasında iletişimi sağlamak, ruhsal varlıkları davet etmek ya da kovmak gibi çeşitli ritüellerin ve büyüsel uygulamaların ana unsuru olmuştur. Koku, duman ve ateş ile bağlantılı olan tütsünün şekillenmesinde ise dönem, coğrafya, inanç ve kültür belirleyici birer unsur olarak kabul edilebilir. Bu çalışmada bu noktadan hareketle, Özbekistan’ın Harezm bölgesindeki tütsü yakma geleneği incelenmiştir. Makalede, Harezm halkının kullandığı tütsü maddeleri, bu maddelerin hem Harezm’deki hem de diğer inanç ve kültürlerdeki yeri, bölgede tütsünün kullanım alanları ve ritüellerdeki işlevi, ritüellerde ya da büyüsel uygulamalarda tütsü yakan kişiler ve tütsü yakma amaçları belirlenerek değerlendirildi. Bu çalışmanın verilerini ise Harezm bölgesinde 2021-2022 yıllar arasında yaptığım alan araştırmasında elde ettiğim veriler ile literatürde bu bağlamda kaleme alınmış yazılı kaynaklar oluşturmaktadır.
Sengel Tuvalarında Çocukla İlgili Geleneksel Unsurlar ve Bazı Sözler Üzerine
Authors: Gagaa Zolbayar , Koçoğlu Gündoğdu Vildan
Published: June 2024

Rusya Federasyonu’na bağlı Tuva Cumhuriyeti, Tuvaların nüfus çoğunluğunun toplu olarak yaşadığı coğrafyadır. Cumhuriyet dışında Moğolistan ve Çin’de de gruplar hâlinde Tuvalar yaşamaktadır. Çok dilli ve çok kültürlü bir çevrede dillerini, kültürlerini korumaya çalışan Tuvalar geçmişten günümüze bazı geleneksel unsurları ve eski söz varlığını devam ettirmişler bazılarını ise hem dil hem kültür etkileşimi sonucunda kaybetmiş ya da değiştirmişlerdir. Bu makalede Moğolistan’ın Bayan Ölgiy aymağının Sengel ilçesinde yaşayan literatürde Altay ya da Sengel Tuvaları olarak anılan Tuvaların çocukla ilgili geleneksel unsurları ve bir kaç söz varlığı üzerinde durulacaktır. Makale iki bölümden oluşmaktadır. Birinci bölümde Sengel Tuvaları ve dilleri hakkında kısaca bilgi verildikten sonra geleneksel yaşamlarında çocuğa dair bir kaç kültürel unsur, ritüel üzerinde durulmuştur. İkinci bölüm ise çocukla ilgili 11 sözcüğün sözcük yapma yolları ve sözlükselleşme bağlamında değerlendirmesini içermektedir.
Boletín Económico Regional: Eje Cafetero, I trimestre de 2024
Authors:   Sección Sucursales Regionales Estudios Económicos
Published: June 2024

En el primer trimestre del año, la mayoría de las variables de seguimiento de la economía del Eje Cafetero mostró descenso anual. Indicadores asociados con la construcción de edificaciones, la actividad pecuaria y comercial se contrajeron, en tanto que la industria presentó menor dinámica. Estos resultados estarían relacionados con una débil demanda interna, en especial de los hogares, mientras que los desembolsos del sistema financiero se redujeron. Por el contrario, la venta de vivienda nueva aumentó, efecto de una baja base de comparación, y el transporte y la ocupación hotelera estuvieron favorecidos por la celebración de la Semana Santa en marzo. Entretanto, cayeron las exportaciones e importaciones, el desempleo aumentó en Pereira y Manizales, y la inflación al consumidor continuó moderándose en las tres ciudades capitales debido a menor presión alcista en los precios de los alimentos.
Boletín Económico Regional: Suroccidente, I trimestre de 2024
Authors:   Sección Sucursales Regionales Estudios Económicos
Published: June 2024

En el primer trimestre de 2024, la economía de Suroccidente continuó con resultados negativos en sus principales indicadores sectoriales, pero con mejoras frente al año anterior. Un moderado consumo, bajo desempeño de la inversión y lenta dinámica de la economía global afectaron la industria y las ventas externas. A su vez, el comercio disminuyó por el bajo gasto de los hogares, pese a la reducción de la inflación y menores tasas de interés del sistema financiero, sector que registró descensos en los desembolsos de consumo y comercial. En construcción, la superficie construida y las ventas de vivienda cayeron, aunque las obras civiles crecieron por mejoras en la malla vial. En contraste, el sector agropecuario aumentó por la anticipación de cosechas debido a las altas temperaturas. Finalmente, la inflación descendió de manera notable en la región, mientras aumentó el número de desocupados.
Boletín Económico Regional : Suroriente, I trimestre de 2024
Authors:   Sección Sucursales Regionales Estudios Económicos
Published: June 2024

Durante el primer trimestre de 2024, la economía de la región Suroriente señaló aumentos en varias de sus principales actividades. La producción de petróleo creció impulsada por mejoras en la productividad de ciertos campos. También aumentaron el abastecimiento de productos agrícolas y la oferta porcina, este último por mayor consumo dados sus precios competitivos. De igual manera, crecieron algunos indicadores de la construcción y del sistema financiero, incluyendo los créditos para la actividad agropecuaria. Como contraste, el comercio se vio afectado por el costo del financiamiento, lo que redundó en caídas en las percepciones de crecimiento de las ventas y comercialización de automotores. Asimismo, se registró disminución en las exportaciones e importaciones. Finalmente, la tasa de desempleo mostró descenso y la inflación continuó con su tendencia a la baja en Villavicencio.
Multithreaded processes: Solving problems by modeling
Authors: Kochergina T. I.
Published: June 2024

The article discusses the tasks of the "Modeling" section of the informatics course of secondary general education. The proposed tasks illustrate the basic concepts and ideas of multithreaded processes.

The first task is presented in the form of a case. When working on a task, students need to develop an action plan to solve the task, present the plan in the form of a table and diagram. As a result of the work, it is necessary to bring students to the conclusion about the need to divide the entire process into parts and to carry out each part in parallel in order to effectively allocate time.

The second task is intended to prepare students for the Unified State Exam in informatics in 2024 (task 22 "Construction of mathematical models for solving practical problems. Architecture of modern computers. Multiprocessor systems").

When developing and constructing a computational computer model, subsequent visualization of numerical data, and conducting a computer experiment for the purpose of data analysis, the process of developing students' functional literacy continues.