bluuebunny/crossref_metadata_2025 huggingface dataset:
Subsurface storage capacity in structural traps in underexplored sedimentary basins: hydrogen (H
2
) and carbon dioxide (CO
2
) storage on the Irish Atlantic margin
Authors: O'Sullivan Conor M. , Rodriguez-Salgado Pablo , Childs Conrad , Shannon Patrick M. , Murphy Robert J.
Published: August 2024

Methodologies for storage assessment developed for basins with dense data coverage are typically not optimally applicable to underexplored sedimentary basins. To address this, a methodology and workflow for storage assessment in underexplored basins is presented which uses existing datasets to identify structural traps and populate a Fluid-in-Place equation which can be used for a variety of gases including CO
2
and H
2
. This is then applied to the Irish Atlantic margin; Jurassic, Triassic and Carboniferous reservoirs are investigated to understand their reservoir quality and extent, and related seals. Structural trap types are described and the theoretical capacities of three candidate sites with varying data coverage are calculated. The results highlight the potential for underexplored sedimentary basins on the Irish Atlantic margin to support offshore renewable energy projects and reduce Ireland's CO
2
emissions. This workflow is applicable to a variety of underexplored sedimentary basins and emphasizes the utility of legacy hydrocarbon datasets for early-stage subsurface storage assessment. Other aspects of energy storage are also discussed, including anthropogenic salt caverns, other candidate reservoir–seal pairs, and the potential for collaborative infrastructure development with CO
2
emitters and renewable energy projects.
Exploring Thematic Diversity in Classical Chinese Poetry: A Novel Dataset and a BERT-enhanced Ensemble Learning Approach
Authors: Hou Jingrui , Zhang Shitou
Published: August 2024

Classical Chinese poetry, as an essential aspect of cultural heritage, exhibits rich theme diversity often overlooked in natural language processing research. To address this gap, we aim to explore the classification of thematic categories within this literary domain. We curate a dataset of 2,918 annotated poems spanning 7 common themes and propose a BERT-based ensemble learning approach for effective classification. Although this method integrates existing models, it achieves an accuracy and F1 score of over 72% in the 7-class task, surpassing established baselines, and providing a baseline for future research. The experimental findings reveal the effectiveness of ensemble strategies in improving individual base model performance and highlight the potential of the MLP-based ensemble technique. The study contributes to a deeper understanding of thematic categories and textual features in classical Chinese poetry and offers an automated classification system for classical Chinese poems.
Report on the Collab-a-Thon at ECIR 2024
Authors: MacAvaney Sean , Roegiest Adam , Lipani Aldo , Parry Andrew , Engelmann Björn Engelmann , Kreutz Christin Katharina , Meng Chuan , Frayling Erlend , Yang Eugene , Schlatt Ferdinand , Faggioli Guglielmo , Scells Harrisen , Atanassova Iana , Friese Jana , Bevendorff Janek , Sanz-Cruzado Javier , Trippas Johanne , Pathak Kanaad , Dhole Kaustubh , Azzopardi Leif , Fröbe Maik , Bertin Marc , Prasad Nishchal , Zerhoudi Saber , Wang Shuai , Chatterjee Shubham , Jaenich Thomas , Kruschwitz Udo , Wang Xi , Long Zijun
Published: August 2024

We present a report on the Collab-a-thon, a series of sessions at the European Conference on Information Retrieval (ECIR) 2024 designed to help foster new collaborations during a conference. This report presents the motivation and design of the Collab-a-thon, a summary of the discussions covered at each session, and a set of recommendations for conducting similar events in the future. The event is set to run again at ECIR 2025 and planning is underway to pilot the event in a different community at the IEEE International Conference on Distributed Computing Systems (ICDCS) 2025.

Date
: 25--27 March 2024.

Website
: https://www.ecir2024.org/collab-a-thon/.
Report on the 7th International Workshop on Narrative Extraction from Texts (Text2Story 2024) at ECIR 2024
Authors: Campos Ricardo , Jorge Alípio M. , Jatowt Adam , Bhatia Sumit , Litvak Marina , Cordeiro João Paulo , Rocha Conceição , Sousa Hugo , Mansouri Behrooz
Published: August 2024

The Seventh International Workshop on Narrative Extraction from Texts (Text2Story'24) was held on March 24

th

, 2024, in conjunction with the 46

th

European Conference on Information Retrieval (ECIR 2024) in Glasgow, Scotland. Over the day, more than 50 attendees engaged in discussions and presentations focused on recent advancements in narrative representation, extraction, and generation. The workshop featured two invited keynote addresses, fourteen research paper presentations, and a poster session. The workshop proceedings are available online.
1

Date
: 24 March 2024.

Website
: https://text2story24.inesctec.pt/.
Inhibition of 5-HT alleviates PTSD-like behaviors and promotes hippocampal neuroplasticity by modulating hippocampal autophagy in rats
Authors: Bai Shi , Ying Zhong-Ming , Ying Jia-Kang , Zhang Qin-Ying , Lv Yu-Hang , Wu Zhong-Min
Published: August 2024

The study demonstrated that sh-SERT exhibits significant anti-posttraumatic stress disorder (PTSD) effects, potentially mediated in part through the reduction of cellular autophagy to enhance hippocampal synaptic plasticity.
Long‐Term Vegan Meditation Improved Human Gut Microbiota
Authors: Jia Wenrui , Zhen Jianhua , Liu Aijie , Yuan Jingyun , Wu Xiaoli , Zhao Pengfei , Zhao Lu , Li Xiaolu , Liu Qingguo , Huang Guangrui , Xu Anlong
Published: August 2024

Objective. Meditation has been widely used for the treatment of a variety of psychological, cardiovascular, and digestive diseases as well as chronic pain. Vegetarian diets can effectively prevent hypertension, metabolic diseases such as diabetes and obesity, and certain cancers. Meditation and vegetarian diets have been recognized as components of a healthy lifestyle and have therefore attracted more people around the world. Meditation can help regulate overall health through the neural‐endocrine‐immune network. Changes in dietary habits can affect the composition of the intestinal flora, which in turn affects human physiology, metabolism, nutrition, and immune function through the bacteria‐intestine‐brain axis. Here, we aimed to investigate the effect of long‐term meditation and vegan diet on human intestinal flora. Materials and Methods. The present study used 16S rDNA sequencing technology to detect the differences in intestinal flora between 12 healthy vegan subjects receiving long‐term meditation training and 12 healthy omnivorous subjects who never received any meditation training. Results. The results showed that, compared with the subjects in the omnivorous healthy control group who had never received any meditation training, the intestinal flora structure in the people who followed the long‐term vegan meditation practices changed significantly. The intersection set between the results of the LEfSe analysis and the Wilcoxon rank sum test includes 14 bacterial genera. These 14 genera are defined as the dominant genera, and the AUC value was 0.92 in the ROC curve, which demonstrates that the 14 genera can be used as a biomarker to distinguish the two groups. Three beneficial bacteria genera (Bifidobacterium, Roseburia, and Subdoligranulum) were significantly enriched in the meditation group with a threshold of 4, according to the LDAs. The functional prediction of differentially enriched intestinal flora showed that the metabolism of tyrosine, propionate, niacin, and nicotinamide in the intestinal micro‐organisms in the meditation group was significantly reduced compared with those in the control group, while the biosynthesis of flavones, flavone alcohols, butosin, and neomycin; flavonoid‐mediated oocyte maturation; cytoskeleton protein pathways; and antigen processing and presentation were significantly enhanced. Conclusions. These results indicate that long‐term vegan meditation plays a positive role in improving the body’s immunity and adjusting endocrine and metabolic levels, enabling the body to be in a state of good health.
Factors Influencing Hospital Nurses’ Workplace Bullying Experiences Focusing on Meritocracy Belief, Emotional Intelligence, and Organizational Culture: A Cross‐Sectional Study
Authors: Jang Insil , Jang Sun Joo , Chang Sun Ju
Published: August 2024

Aims. To identify the factors influencing hospital nurses’ workplace bullying experiences (victim and perpetrator aspects) focusing on meritocracy beliefs, emotional intelligence, and organizational culture. Background. Workplace bullying remains a major issue in nursing despite decades of research and policy‐making. Therefore, comprehensively understanding the individual and institutional factors affecting workplace bullying from both the victim and perpetrator perspectives is crucial. Methods. In October 2022, 379 nurses working in South Korean tertiary hospitals were surveyed using a self‐reported online questionnaire. Meritocracy beliefs, emotional intelligence, workplace bullying experiences, and nursing organizational culture were measured using the Meritocracy Belief Scale, Wong and Law Emotional Intelligence Scale, Negative Acts Questionnaire‐Revised, and Positive Nursing Organizational Culture Measurement Tool, respectively. Results. Gamma regression analysis revealed that, for workplace bullying, the factors influencing the victim aspect were the experience of witnessing bullying in the workplace, organizational culture, and meritocracy beliefs. In contrast, the factors affecting the perpetrator aspect were emotional intelligence, meritocracy beliefs, and experience of bullying at work. Conclusion. Decreasing nurses’ degree of meritocratic hubris in a positive organizational culture and increasing their emotional intelligence are necessary to prevent and intervene in workplace bullying. Implications for Nursing Management. Targeted approaches are needed to address and mitigate the detrimental effects of factors influencing workplace bullying. These approaches could include interventions that improve nurses’ emotional intelligence, assess their level of meritocracy beliefs, and offer opportunities for self‐reflection on meritocratic hubris. Such initiatives may be necessary to effectively tackle workplace bullying and promote a healthier nursing work environment.
Improving the Control Strategy of the DVR Compensator Based on an Adaptive Notch Filter with an Optimized PD Controller Using the IGWO Algorithm
Authors: Alrashed Mohammed M. , Flah Aymen , Dashtdar Masoud , El-Bayeh Claude Ziad , Elnaggar Mohamed F.
Published: August 2024

One of the objectives of electrical distribution networks is to provide customers with access to high‐quality electricity. Because any disruptions in these systems result in voltage disorders, different devices are employed to offset these disruptions on consumers who are more susceptible. One of the most important and contemporary pieces of equipment that is connected in series with the network is dynamic voltage restoration (DVR), which shields delicate loads from network voltage issues by injecting the proper voltage. This article presents a DVR control scheme optimized with improved grey wolf optimization (IGWO) that uses a proportional derivative (PD) controller and adaptive notch filter (ANF). The output LC filter’s resistance has been removed, and the control system has actively engaged in oscillation damping in order to accelerate dynamic responsiveness and lower system losses. The major component of the voltage, which comprises its frequency, amplitude, and phase, is extracted using ANF. The capacitor current of the output filter in this structure is fed back to the control system and from the current mode control in the inner loop to boost stability. Owing to the occasionally complex dynamic behavior in distribution networks, particularly during a fault, the system’s frequency response has been altered and response speed has been accelerated using the PD controller. This kind of controller is distinguished by its accurate functioning in the presence of frequency deviations and its swifter dynamic reaction in the face of voltage swell and sag. In order to improve the THD and voltage sag indicators of the sensitive load, the PD coefficients were adjusted using the IGWO algorithm. As a consequence, the simulation results demonstrated that the suggested controller performed better than traditional controllers.
Effectiveness Assessment of Bispectral Index Monitoring Compared with Conventional Monitoring in General Anesthesia: A Systematic Review and Meta‐Analysis
Authors: Gu Yichun , Hao Jiajun , Wang Jiangna , Liang Peng , Peng Xinyi , Qin Xiaoxiao , Zhang Yunwei , He Da
Published: August 2024

Background and Objective. The Bispectral Index (BIS) is utilized to guide the depth of anesthesia monitoring during surgical procedures. However, conflicting results regarding the benefits of BIS for depth of anesthesia monitoring have been reported in numerous studies. The purpose of this meta‐analysis and systematic review was to assess the effectiveness of BIS for depth of anesthesia monitoring. Search Methods. A systematic search of Ovid‐MEDLINE, Cochrane, and PubMed was conducted from inception to April 20, 2023. Clinical trial registers and grey literature were also searched, and reference lists of included studies, as well as related review articles, were manually reviewed. Selection Criteria. The inclusion criteria were randomized controlled trials without gender or age restrictions. The control groups used conventional monitoring, while the intervention groups utilized BIS monitoring. The exclusion criteria included duplicates, reviews, animal studies, unclear outcomes, and incomplete data. Data Collection and Analysis. Two independent reviewers screened the literature, extracted data, and assessed methodological quality, with analyses conducted using R 4.0 software. Main Results. Forty studies were included. In comparison to the conventional depth of anesthesia monitoring, BIS monitoring reduced the postoperative cognitive dysfunction risk (RR = 0.85, 95% CI: 0.73∼0.99, P = 0.04), shortened the eye‐opening time (MD = −1.34, 95% CI: −2.06∼−0.61, P < 0.01), orientation recovery time (MD = −1.99, 95% CI: −3.62∼−0.36, P = 0.02), extubation time (MD = −2.54, 95% CI: −3.50∼−1.58, P < 0.01), and postanesthesia care unit stay time (MD = −7.11, 95% CI: −12.67∼−1.55, P = 0.01) and lowered the anesthesia drug dosage (SMD = −0.39, 95% CI: −0.63∼−0.15, P < 0.01).​ Conclusion. BIS can be used to effectively monitor the depth of anesthesia. Its use in general anesthesia enhances the effectiveness of both patient care and surgical procedures.
Analyzing the Reliability of a Pumping System through the Application of Copula Analysis
Authors: Elshoubary Elsayed , Radwan Taha
Published: August 2024

This paper derives and evaluates the reliability measures for a model pumping system composed of six subsystems linked in series: subsystems 1, 2, and 6, each comprising one unit, while subsystems 3 and 5 each contain three units operating in parallel. Subsystem 4 contains three units effectively operating in series. Unit failure rates are assumed to be constant, while repair rates are modeled by either a general distribution or, in the event of system failure, a Gumbel–Hougaard copula. The Laplace transform and additional supplementary variable approaches are employed to solve the system. The conventional measures of reliability are computed for a range of parameter values and as functions of time. In addition, tables are presented containing parameters for different cases, accompanied by a discussion of how they were chosen and their impact on the results.
Supports Provided to People with Intellectual Disability and Dysphagia to Assist with Participation in Eating and Drinking: A Scoping Review
Authors: Cox Gillian , Wylie Karen , Leitão Suze , Cocks Naomi
Published: August 2024

Many people with intellectual disability live with swallowing, eating, and drinking difficulties (dysphagia). People living with both intellectual disability and dysphagia may require a range of supports in order to have the opportunity to participate in different eating and drinking environments of their choice. Understanding the nature of those supports is important to ensure that people with intellectual disability living with dysphagia can continue to create a good life for themselves at home and in their community. This study aimed to identify the nature of supports provided to people with intellectual disability and dysphagia when eating and drinking in different environments, as described in the published literature. A scoping review, underpinned by an a priori protocol, was conducted by a team of four reviewers. Four databases were searched. Sixteen papers were included for full‐text review. The review identified that studies most frequently reported support in the form of safety strategies to prevent the ill‐health consequences of dysphagia and training carers in those safety strategies by speech‐language pathologists. To a much lesser extent, studies identified the psychosocial needs of people with intellectual disability and dysphagia and how these were being considered in the design of training support. Overall, this review identified a significant need for future research into supports for eating outside the home and collaboration with people with intellectual disability and dysphagia about dysphagia training content which reflects the experience of living with dysphagia in social community environments.
How Does Rescuer’s Position Setting Impact Quality of Chest Compression: A Randomized Crossover Simulation Study on Unexperienced Clinicians
Authors: Zhang Nan , Wang Jiangshan , Li Yan , Liu Jihai , Zhu Huadong
Published: August 2024

Background. High‐quality chest compression (CC) is the crux of survival for cardiac arrest patients. While, rescuers’ position setting relative to patients during CC was unrecommended in the present guidelines. We aimed to assess the impact of position settings on CC quality during cardiopulmonary resuscitation (CPR) and to test the heterogeneity related to rescuers’ characteristics. Methods. We conducted randomized, crossover, simulation trials with clinical students unfamiliar with CPR. The participants received standard training on performing CC and were divided randomly into two groups. The two groups separately performed CC with standing and kneeling positions in turn, forming the crossover design. The trials were performed with standard manikin models. CC quality indicator data were recorded by the tracking and feedback system automatically. Result. 156 participants finished at least one round of trial, with 126 participants finishing both rounds. Records for CC with kneeling and standing positions showed statistically significant differences in the correct rate, pause happening, average depth, and happening of over‐depth compression. Regression analysis also implied that larger compression depths with the standing position were related to larger height and BMI of the participants. Conclusion. When performing CC, the standing position will lead to lower CC quality by larger chance of pause happening and over‐depth compression. In addition, compression depth gaps between CC with kneeling and standing position were related with rescuer characteristics including height and BMI, with a threshold effect.
Table S1 from Medical Care Costs Associated with Cancer Survivorship in the United States
Authors: Mariotto Angela B. , Enewold Lindsey , Zhao Jingxuan , Zeruto Christopher A. , Yabroff K. Robin
Published: August 2024

Table S1 shows cancer-attributable annualized average costs for oral prescription drugs by Part D low income subsidy status
Supplementary Data TS1-4 from Sustained Minimal Residual Disease Negativity in Multiple Myeloma is Associated with Stool Butyrate and Healthier Plant-Based Diets
Authors: Shah Urvi A. , Maclachlan Kylee H. , Derkach Andriy , Salcedo Meghan , Barnett Kelly , Caple Julia , Blaslov Jenna , Tran Linh , Ciardiello Amanda , Burge Miranda , Shekarkhand Tala , Adintori Peter , Cross Justin , Pianko Matthew J. , Hosszu Kinga , McAvoy Devin , Mailankody Sham , Korde Neha , Hultcrantz Malin , Hassoun Hani , Tan Carlyn R. , Lu Sydney X. , Patel Dhwani , Diamond Benjamin , Shah Gunjan , Scordo Michael , Lahoud Oscar , Chung David J. , Landau Heather , Usmani Saad Z. , Giralt Sergio , Taur Ying , Landgren C. Ola , Block Gladys , Block Torin , Peled Jonathan U. , van den Brink Marcel R.M. , Lesokhin Alexander M.
Published: August 2024

Supplementary Table S1-S4
Supplementary Table S3 from Senescence Rewires Microenvironment Sensing to Facilitate Antitumor Immunity
Authors: Chen Hsuan-An , Ho Yu-Jui , Mezzadra Riccardo , Adrover Jose M. , Smolkin Ryan , Zhu Changyu , Woess Katharina , Bernstein Nicholas , Schmitt Georgia , Fong Linda , Luan Wei , Wuest Alexandra , Tian Sha , Li Xiang , Broderick Caroline , Hendrickson Ronald C. , Egeblad Mikala , Chen Zhenghao , Alonso-Curbelo Direna , Lowe Scott W.
Published: August 2024

Low (50 pg/ml) and high (1 ng/ml) dose of IFN-γ treatment in proliferating and senescent NSP cells.
Supplementary Table S1 from Senescence Rewires Microenvironment Sensing to Facilitate Antitumor Immunity
Authors: Chen Hsuan-An , Ho Yu-Jui , Mezzadra Riccardo , Adrover Jose M. , Smolkin Ryan , Zhu Changyu , Woess Katharina , Bernstein Nicholas , Schmitt Georgia , Fong Linda , Luan Wei , Wuest Alexandra , Tian Sha , Li Xiang , Broderick Caroline , Hendrickson Ronald C. , Egeblad Mikala , Chen Zhenghao , Alonso-Curbelo Direna , Lowe Scott W.
Published: August 2024

Differential expression analyses of CD8 T and macrophages populations of proliferating (p53 off) vs. senescent (p53 on) tumors by scRNA-seq.
Figure 1 from Senescence Rewires Microenvironment Sensing to Facilitate Antitumor Immunity
Authors: Chen Hsuan-An , Ho Yu-Jui , Mezzadra Riccardo , Adrover Jose M. , Smolkin Ryan , Zhu Changyu , Woess Katharina , Bernstein Nicholas , Schmitt Georgia , Fong Linda , Luan Wei , Wuest Alexandra , Tian Sha , Li Xiang , Broderick Caroline , Hendrickson Ronald C. , Egeblad Mikala , Chen Zhenghao , Alonso-Curbelo Direna , Lowe Scott W.
Published: August 2024

A p53-restorable tumor model to study senescence immune surveillance. A, Generation of the p53-restorable, NRAS-driven mouse liver cancer model using the sleeping beauty transposon system delivered through HTVI. (Created with BioRender.com.) B, Representative ultrasonogram of HTVI and orthotopic injection liver cancer models at indicated time after p53 restoration. C, Survival analysis of mice in the HTVI model. D, Representative hematoxylin and eosin (H&E), immunofluorescence (IF), and senescence-associated β-galactosidase (SA-β-gal) staining of p53-suppressed (p53 off) and -restored (p53 on for 14 days) tumor sections generated from the HTVI model. Scale bars, 50 μm. E–G, Orthotopic injection of GFP-luciferase vector-transduced NSP tumor cells into the livers of immunocompetent and immunodeficient mouse strains. E, Tumor size change measured by ultrasound upon p53 restoration. R2G2, Rag2-Il2rg double-knockout mouse. Data are presented as mean ± SEM. n e 9 for each strain. F, Representative macroscopic pictures at 21 days of p53 on or endpoint p53 off tumor. G, Representative IHC staining of GFP-labeled tumor cells at day 21 upon p53 restoration. Scale bars, 100 μm. **, P < 0.01; ***, P < 0.001.
Supplementary Figure 9 from Molecular Pathways and Cellular Subsets Associated with Adverse Clinical Outcomes in Overlapping Immune-Related Myocarditis and Myositis
Authors: Siddiqui Bilal A. , Palaskas Nicolas L. , Basu Sreyashi , Dai Yibo , He Zhong , Yadav Shalini S. , Allison James P. , Sheth Rahul A. , Tummala Sudhakar , Buja Maximilian , Bhattacharjee Meenakshi B. , Iliescu Cezar , Rawther-Karedath Anishia , Deswal Anita , Wang Linghua , Sharma Padmanee , Subudhi Sumit K.
Published: August 2024

Comparison of myeloid cell subclusters in cardiac muscle with previously reported subsets in human heart
Supplementary Figure 6 from Molecular Pathways and Cellular Subsets Associated with Adverse Clinical Outcomes in Overlapping Immune-Related Myocarditis and Myositis
Authors: Siddiqui Bilal A. , Palaskas Nicolas L. , Basu Sreyashi , Dai Yibo , He Zhong , Yadav Shalini S. , Allison James P. , Sheth Rahul A. , Tummala Sudhakar , Buja Maximilian , Bhattacharjee Meenakshi B. , Iliescu Cezar , Rawther-Karedath Anishia , Deswal Anita , Wang Linghua , Sharma Padmanee , Subudhi Sumit K.
Published: August 2024

Analysis of total CD45+ immune cell populations
Supplementary Figure 3 from Molecular Pathways and Cellular Subsets Associated with Adverse Clinical Outcomes in Overlapping Immune-Related Myocarditis and Myositis
Authors: Siddiqui Bilal A. , Palaskas Nicolas L. , Basu Sreyashi , Dai Yibo , He Zhong , Yadav Shalini S. , Allison James P. , Sheth Rahul A. , Tummala Sudhakar , Buja Maximilian , Bhattacharjee Meenakshi B. , Iliescu Cezar , Rawther-Karedath Anishia , Deswal Anita , Wang Linghua , Sharma Padmanee , Subudhi Sumit K.
Published: August 2024

Analysis of CD45- subpopulations in cardiac muscle
Supplementary Figure 14 from Molecular Pathways and Cellular Subsets Associated with Adverse Clinical Outcomes in Overlapping Immune-Related Myocarditis and Myositis
Authors: Siddiqui Bilal A. , Palaskas Nicolas L. , Basu Sreyashi , Dai Yibo , He Zhong , Yadav Shalini S. , Allison James P. , Sheth Rahul A. , Tummala Sudhakar , Buja Maximilian , Bhattacharjee Meenakshi B. , Iliescu Cezar , Rawther-Karedath Anishia , Deswal Anita , Wang Linghua , Sharma Padmanee , Subudhi Sumit K.
Published: August 2024

Cell-cell communication analysis from myeloid cells and cytotoxic T cells to endothelial cells in myositis
Supplementary Figure 1 from Molecular Pathways and Cellular Subsets Associated with Adverse Clinical Outcomes in Overlapping Immune-Related Myocarditis and Myositis
Authors: Siddiqui Bilal A. , Palaskas Nicolas L. , Basu Sreyashi , Dai Yibo , He Zhong , Yadav Shalini S. , Allison James P. , Sheth Rahul A. , Tummala Sudhakar , Buja Maximilian , Bhattacharjee Meenakshi B. , Iliescu Cezar , Rawther-Karedath Anishia , Deswal Anita , Wang Linghua , Sharma Padmanee , Subudhi Sumit K.
Published: August 2024

Clinical characteristics of patients with confirmed toxicities
Table 1 from FLT3/CD99 Bispecific Antibody–Based Nanoparticles for Acute Myeloid Leukemia
Authors: Ali Atham , Phan Alvin , Vaikari Vijaya , Park Mincheol , Pospiech Mateusz , Chu Ryan , Meng Yiting , MacKay John A. , Alachkar Houda
Published: August 2024

Summary of expressed polypeptides
Figure S4 from FLT3/CD99 Bispecific Antibody–Based Nanoparticles for Acute Myeloid Leukemia
Authors: Ali Atham , Phan Alvin , Vaikari Vijaya , Park Mincheol , Pospiech Mateusz , Chu Ryan , Meng Yiting , MacKay John A. , Alachkar Houda
Published: August 2024

Figure S4 – qPCR analysis results for CDC25A, E2F1, CDKN2B, CDC20, and MYC in MV4-11 cells treated with with FLT3-A192, CD99-A192 and Co-Assembled CD99-A192 and FLT3-A192.
Figure S3 from FLT3/CD99 Bispecific Antibody–Based Nanoparticles for Acute Myeloid Leukemia
Authors: Ali Atham , Phan Alvin , Vaikari Vijaya , Park Mincheol , Pospiech Mateusz , Chu Ryan , Meng Yiting , MacKay John A. , Alachkar Houda
Published: August 2024

Figure S3 – Western Blot data from USC100 following treatment with FLT3-A192, CD99-A192 and Co-Assembled CD99-A192 and FLT3-A192.
Figure 7 from FLT3/CD99 Bispecific Antibody–Based Nanoparticles for Acute Myeloid Leukemia
Authors: Ali Atham , Phan Alvin , Vaikari Vijaya , Park Mincheol , Pospiech Mateusz , Chu Ryan , Meng Yiting , MacKay John A. , Alachkar Houda
Published: August 2024

Signaling pathways and genes affected by the treatment with CD99/FLT3 fusion proteins. Following incubation of MV4-11 with treatments or controls, cell lysates were assessed using western blot against common signaling pathways associated with AML. A–D, 3 hours timepoints did not show drastic changes in SRC, ERK, and STAT5 pathways. E–H, Treatment with targeted fusion proteins reduced phosphorylation of kinases associated with AML. For example, an increase of P-SRC at 24 hours is consistent with CD99 inhibition. Image analysis was used to quantify and compare relative activation of pSTAT5, pSRC, and pERK. I, RNA-seq analysis was performed on MV4-11 cells. A Venn diagram shows the number of differentially expressed genes for cells treated with FLT3-A192, CD99-A192, or the Co-Assembled formulation. J, Differential RNA expression was analyzed using GSEA. All three treatments cluster for genes associated with cancer growth and progression. K, Treatment with FLT3-A192, CD99-A192, and Co-Assembled result in different pathways being enriched and downregulated; FDR < 25%.
Figure 5 from FLT3/CD99 Bispecific Antibody–Based Nanoparticles for Acute Myeloid Leukemia
Authors: Ali Atham , Phan Alvin , Vaikari Vijaya , Park Mincheol , Pospiech Mateusz , Chu Ryan , Meng Yiting , MacKay John A. , Alachkar Houda
Published: August 2024

Treatment with fusion protein formulations significantly reduced leukemia burden in NSG mice. A–C, 2 × 106 MV4-11 cells were engrafted IV into NSG mice. Mice were then treated with either A192, FLT3-A192, CD99-A192, or Co-Assembled at a dose of 250 mg/kg every other day beginning at either day 7 or day 10, ending between day 21 to 28. A and B, Peripheral blood samples, (C and D) spleen samples, and (E and F) bone marrow samples show a lower percentage of huCD45+ cells between A192 and all three treatment groups. G, We engrafted 2 × 106 MV4-11 cells into NSG mice and treated these mice at day 8, 10, 12, 14, 16, 18, 20, and 22 post engraftment, Kaplan–Meier survival analysis shows that mice treated with Co-Assembled survived longer than mice receiving FLT3-A192 alone. Mean ± SD (n > 5).
Figure 1 from FLT3/CD99 Bispecific Antibody–Based Nanoparticles for Acute Myeloid Leukemia
Authors: Ali Atham , Phan Alvin , Vaikari Vijaya , Park Mincheol , Pospiech Mateusz , Chu Ryan , Meng Yiting , MacKay John A. , Alachkar Houda
Published: August 2024

Interplay between CD99 and FLT3 in FLT3-ITD AML. Flow cytometry was used to evaluate the surface level expression of FLT3 and CD99. A and B, Compared to naive MV4-11 cells, midostaurin-resistant (MV4-11-R) cells have a significant increase of surface expression of FLT3 (P = 0.0356), and trend of increase of CD99 (P = 0.0568). C, To examine the effect of targeting CD99 on FLT3 surface expression, a panel of cell lines were assessed. U937 do not express FLT3 and were included as negative control. D, THP-1 cells, although they express the FLT3-WT, did not show enhance FLT3 surface level expression upon treatment with CD99-A192. E, In contrast, treatment with CD99-A192 increased FLT3 surface level expression in MOLM-13 cells, which are FLT3-ITD+ (P = 0.05). F, NSG mice were engrafted with 2.5 × 106 MOLM-13 cells, showed a significant increase in survival when treated with both FLT3 and CD99 targeted nanoparticles P < 0.007 and P < 0.003 of combination vs. CD99-A192, FLT3-A192 alone respectively.
FIGURE 4 from Persistent Ethnicity-Associated Disparity in Antitumor Effectiveness of Immune Checkpoint Inhibitors Despite Equal Access
Authors: Florez Marcus A. , Kemnade Jan O. , Chen Nan , Du Wendy , Sabichi Anita L. , Wang Daniel Y. , Huang Quillan , Miller-Chism Courtney N. , Jotwani Aparna , Chen Albert C. , Hernandez David , Sandulache Vlad C.
Published: August 2024

Immune-related adverse events (irAE) within the entire treatment cohort. A, Overall irAE rate as a function of race/ethnic group. B, ORR as a function of irAE for the ICI monotherapy cohort. PR, partial response; SD, stable disease; PD, progressive disease.
FIGURE 1 from Persistent Ethnicity-Associated Disparity in Antitumor Effectiveness of Immune Checkpoint Inhibitors Despite Equal Access
Authors: Florez Marcus A. , Kemnade Jan O. , Chen Nan , Du Wendy , Sabichi Anita L. , Wang Daniel Y. , Huang Quillan , Miller-Chism Courtney N. , Jotwani Aparna , Chen Albert C. , Hernandez David , Sandulache Vlad C.
Published: August 2024

Best overall response. A, ORR data for all patients and by disease category for patients treated with either ICI monotherapy or chemo/ICI combination therapy. B, ORR data for all patients and by disease category for patients treated with ICI monotherapy. C, ORR data for patients with NSCLC stratified by PD-L1 status treated with ICI monotherapy. Only patients for whom PD-L1 was known were included.
ECOLOGICAL EFFECTS OF BELIK RIVER HYDRAULIC CHARACTERISTICS ON PERIPHYTON COMMUNITY AS WATER QUALITY BIOINDICATOR
Authors: Wahyu Sartika Heni , Hadisusanto Suwarno , Sulaiman Muhammad
Published: August 2024

ARTICLE HIGLIGHTS- Differences in river hydraulic characteristics affect ecological river health- The influence of flooding on the dynamics of physical and chemical characteristics of river water- Life strategy, adaptation of periphyton to environmental changes- Development of green infrastructure for river conservationABSTRACTBelik River is one of the urban rivers in the Special Region of Yogyakarta which has hydrological problems both in quantity and quality. This triggered the construction of various types of channel modifications. This study aimed to identify water quality and the ecological effects of channel modifications based on the presence of periphyton communities as bioindicators. Sampling was carried out in January 2021 and March 2021. Samples were taken at 4 sampling sites with different channel characteristics with 3 repetitions at each location. The physico-chemical parameters measured included pH, detergent, nitrate, sulfate, total phosphate, TSS, TDS, DO, CO2, water temperature, depth, transparency, discharge, and current velocity. The results showed that the abundance of periphyton in January 2021 was higher than in March 2021. In January 2021 there were found 91 periphyton species dominated by Nitzschia improvisa, Nitzschia terricola, and Nitzschia philippinarum. Meanwhile, in March 2021 there were found 61 species of periphyton dominated by Nitzschia improvisa. Based on the results of Canonical Correlation Analysis (CCA), it was shown that in general the distribution and abundance of periphyton in the Belik River were influenced by CO2, total phosphate, discharge, DO, nitrate, TSS, and depth. The Shannon Wiener Diversity Index showed that water quality in January 2021 has decreased in March 2021. From the cluster analysis, it is known that there are differences in water quality and abundance of periphyton in the four types of river channels. It can be concluded that differences in hydraulic characteristics affected water quality and the ecological health of Belik River.
Glomus mosseae AND Pseudomonas fluorescens AGAINST Soybean mosaic virus UNDER DRIP IRRIGATION SYSTEM
Authors: Andayanie Wuye Ria , Adinurani Praptiningsih Gamawati , Lukito Martin
Published: August 2024

ARTICLE HIGLIGHTS- Glomus mosseae and Pseudomonas fluorescens enhance soybean resistance to SMV.- Ten-day drip irrigation stop at bloom stage boosts seed yield and weight.- Treatment reduces disease severity and increases P. fluorescens population.- Water-saving irrigation method improves soybean performance in dry seasons.- Combining G. mosseae and P. fluorescens increases soybean productivity.
ABSTRACTSoybeans [Glycine max (L.) Merr.] require much water, especially in the early stages of growth, flowering, and pod formation and filling. Drought stress on soybeans will increase with global climate change. The research aimed to evaluate the efficacy of Glomus mosseae and Pseudomonas fluorescens in inducing systemic resistance to control Soybean Mosaic Virus (SMV) and the performance of soybean plants with drip irrigation in the dry season. The drip irrigation was stopped for ten days at the beginning of bloom, full bloom, beginning pod, and regular drip irrigation. The application of G. mosseae inoculants used 100 g of sterile compost mixed with 30 spores. The liquid inoculum of P. fluorescens was applied on cotyledonary leaves using the watering method. The plants were inoculated with SMV 6 and 12 days after the P. fluorescens treatment. The symptoms of SMV were recorded two weeks after inoculation, and Indirect ELISA detected the virus. The results showed the combination of G. mosseae and P. fluorescens under drip irrigation stopped at the beginning of bloom for ten days on ELISA absorbance values and disease severity of 0.259 and 3.72 %, respectively. Moreover, this treatment showed the highest values for the 100-seed weight, seed yield, and fresh weight of leaves. The technique of giving water by stopping drip irrigation at the beginning of bloom for ten days will help save water and increase the P. fluorescens population optimally in Alfisols with a pH of between 4.5 and 5.1 with incredibly low fertility. The combination of G. mosseae and P. fluorescens population resulted in a significant increase in the number of G. mosseae’s spores by stopping drip irrigation at the beginning of bloom for ten days.
TROPICAL PALMS AND FACTORS INFLUENCING THEIR DISTRIBUTIONS AND DIVERSITY, WITH A FOCUS ON Pinanga DIVERSITY IN SOUTHEAST ASIA
Authors: Abdullah Mohamad Farid , Md Jaafar Salwana , Ahmad Norhayati , Sukri Rahayu Sukmaria
Published: August 2024

ARTICLE HIGLIGHTS- The palm genus Pinanga is the most diverse in Southeast Asia. - Limited ecological studies on Pinanga show the influence of environmental factors.- High Pinanga endemism in Borneo requires conservation action.ABSTRACTPalms represent some of the keystone species in tropical forests, providing numerous ecosystem services. They are widely studied by botanists because of their iconic and majestic appearance, although ecological studies of palm abundance, distributions, and diversity have only recently begun to gain attention. The abundance and diversity of palms at different spatial scales can be influenced by various factors, such as climate, soil properties, hydrology, topography and forest structure; understanding these influences is essential for conservation. This review details four abiotic factors (climate, soil chemistry, hydrology and topography) and one biotic factor (forest structure) affecting palm distribution and diversity. The genus Pinanga, one of the most diverse genera of palms, is discussed in terms of its distribution and diversity in Southeast Asia. Ecological studies on Pinanga diversity in the region are examined, revealing the influence of micro- and macro-scale variation in environmental factors, such as litter depth and thickness, canopy openness and crown cover, elevation, slope, aspect, light intensity, humidity and air temperature. The existing knowledge gaps on Pinanga ecology in Southeast Asia are discussed, and the need for more studies on population structures, functional traits and determinants of Pinanga diversity and distributions within different lowland forest types in the region are highlighted. The high endemism shown by Pinanga necessitates a more comprehensive ecological understanding of this genus to better inform its conservation and protection.
THE POTENCY OF CINNAMON (Cinnamomum burmanni Blume) LEAF EXTRACT AS A BIOPRESERVATIVE AGENT FOR FOOD SAFETY OF SATE LILIT
Authors: Darmayasa Ida Bagus Gede , Ramona Yan , Darmadi Anak Agung Ketut , Suanda I Wayan , Hani Ni Luh , Shetty Kalidas
Published: August 2024

ARTICLE HIGLIGHTS- Cinnamon leaf extract combats E. coli in traditional Balinese food.- Natural preservative reduces harmful pathogens in sate lilit.- Cinnamon extract offers a safer alternative to synthetic preservatives.- Active compounds in cinnamon leaves inhibit bacterial growth.- Effective biopreservative for enhancing food safety and quality.
ABSTRACTEscherichia coli O157:H7 contamination of the meat used in preparing sate lilit, a favorite traditional food in Bali, Indonesia, has been a great concern for both local people and foreigners. Although C. burmanni has been included in its spice ingredients, active compounds that play a significant role in this pathogen have limitedly been elucidated. The main objectives of this research were to investigate the potency of this plant to control contaminants and elucidate possible compounds that prevent such contaminants by applying the disk diffusion method and LCMS analysis, respectively. The results showed that the leaf extract of this plant inhibited the in vitro growth of E. coli O157:7, with minimal inhibitory concentration (MIC) and LC50 values of 4% and 2.59%, respectively. The LCMS analysis chromatogram showed that the plant extract's most active fraction produced nine peaks, representing nine possible active compounds. Among those, three compounds (Azoxystrobin, Stigmatellin Y, and 2-arachidonoyl glycerol) were suspected of contributing to control contamination, especially by E. coli O157:H7.
Abstract 10837: Brain Natriuretic Peptide, but Not Calprotectin or the Long Pentraxin 3 Independently Predicts Stroke in Long-Term Follow-up of Patients With Acute Coronary Syndrome.
Authors: Ponitz Volker , Brugger- Andersen Trygve , Grundt Heidi , Mjelva Oistein , Staines Harry , Nilsen Dennis W
Published: August 2024

Background:
Besides its predictive utility for mortality, Brain Natriuretic Peptide (BNP) also predicts stroke in a general population, patients with heart failure and in patients undergoing haemodialysis. Less evidence exists whether BNP or the novel cardiac biomarkers Calprotectin and The Long Pentraxin 3 (PTX3) may predict stroke in patients admitted with acute coronary syndrome (ACS).

Methods:
Admission BNP, PTX3 and Calprotectin were measured in 795 patients admitted with symptoms suspective of an ACS. Multivariate analysis was performed using a Cox Proportional Hazard Ratio model. Variables included in the model were BNP, Calprotectin, PTX3 and 18 conventional risk factors for cardiovascular disease including heart failure, hypertension and hs-CRP.

Results:
27 out of 795 patients had an incident of stroke during the follow-up time of two years. Admission level of BNP above the median (median 95pg/mL) significantly predicted stroke (HR 6.7; 95% CI 2.3–19.6, p<0.001, KM survival plot displayed in figure). Following adjustment in the multivariate analysis, BNP remained an independent predictor for stroke (HR 3.2; 95% CI 1.0–9.7, p<0.05). In contrast, neither Calprotectin nor PTX3 provided independent prognostic information for stroke.

Conclusions:
Admission level of BNP but not of Calprotectin or PTX3 independently predicts stroke in long term follow-up of patients admitted with chest pain suspective of an ACS.
Abstract 12516: Changes of Electrophysiological Data Through the Life in the Preexcitation Syndrome
Authors: Brembilla-Perrot Béatrice , Zinzius Pierre Yves , Khachab Hadil , Jarmouni Soumaya , Laporte Franck , Muresan Lucian , Aliot Etienne , Schwartz Jérôme , Beurrier Daniel , Andronache Marius , Moulin-Zinsch Anne , Marcon Francois
Published: August 2024

Background:
The number of accessory pathway (AP) ablations has dramatically increased and the natural follow-up of Wolff-Parkinson White syndrome (WPW) becomes not possible. Changes of electrophysiological data were reported. The purpose of the study was to report the clinical and electrophysiological data of patients with a WPW, studied within 1 to 20 years of one another to evaluate the changes of the data.

Methods:
2 baseline EPS were performed within 1 to 20 years of one another (mean 9 y ± 4) in 62 patients, 37 males and 25 females, aged initially from 10 to 67 y (31±15), with a patent WPW. First electrophysiological study (EPS) was indicated for syncope (n=7), atrioventricular reentrant tachycardias (AVRT) (n=34), atrial fibrillation (AF) (n=5) or for asymptomatic preexcitation (n= 16). The protocol was similar: the higher rate conducted through AP was measured and programmed atrial stimulation with 1 and 2 ES performed in control state (CS) and after isoproterenol.

Results:
At 2
nd
study, among patients studied for syncope at study 1, 2 have still syncope, 2 have AVRT, 1 has rapid AF, and 2 are asymptomatic. Among patients with AVRT at study 1, 25 have AVRT, 7 are asymptomatic and 2 have AF. Among patients with AF, 4 have still AF and 1 is asymptomatic. Among asymptomatic patients, 3 have a spontaneous malignant form, 7 remain asymptomatic, 3 have AVRT, 1 has syncope and 1 has AF. All AVRT's or AF's occurred in patients with inducible AVRT or AF at EPS 1. The higher rate conducted by AP was significantly lower in CS and after isoproterenol at EPS 2 (157±95 b/min, 193±113) than at EPS 1 (199±65, 257±65). AP has lost anterograde conduction properties in 18 patients aged from 17 to 67 years (47±15); 16 of them had initially 1/1 conduction through AP ≤ 170/min; however 8 had still AVRT. Among 24 patients with initially rapid conduction through AP (≥ 240/min), 17 have a rapid conduction at EPS 2; 3 of them, which were asymptomatic developed rapid AF, but 2 became asymptomatic with a benign form.

Conclusions:
The study confirms that a benign form of WPW without inducible AVRT or AF remains benign and that AP ablation is not indicated. Patients with AVRT and AP with a long refractory period become asymptomatic in 20 % of cases. Patients with inducible rapid AF have still a malignant form in 71 % of cases.
Age-Related Blood Pressure Gradients Are Associated With Blood Pressure Control and Global Population Outcomes
Authors: Nolde Janis M. , Beaney Thomas , Carnagarin Revathy , Stergiou George S. , Poulter Neil R. , Schutte Aletta E. , Schlaich Markus P.
Published: August 2024

BACKGROUND:

The strong relationship between blood pressure (BP) and age is well known. Limited evidence suggests that a steeper age-BP slope may be associated with an increased risk of adverse outcomes. The May Measurement Month campaign enables an investigation of geographic, socioeconomic, and sex differences in age-related BP gradients and their association with public-health outcomes.

METHODS:

Cross-sectional, annual global BP May Measurement Month screening data were analyzed. Average systolic BP and age-related BP slopes across different age groups were calculated to assess regional, socioeconomic, and sex-stratified variations. The association of BP slopes derived from adjusted linear regression models with country-level health metrics was investigated.

RESULTS:

Age-related systolic BP gradients differed distinctly across global geographic regions, income levels, and between sexes. The steepest age gradients of BP were observed in populations from Africa and Europe. Women had lower BP levels than men at younger ages (20s and 30s) but subsequently experienced more pronounced age-related BP gradients. Geographically divergent age-related BP gradients were significantly associated with major national public health indicators. Globally, steeper age-related BP slopes were associated with poor BP control, increased disability-adjusted life years, and death rates. A steeper population age-BP slope of 1 mm Hg per 10 years was associated with a decrease in life expectancy of 3.3 years in this population (95% CI, −5.1 to −1.4;
P
=0.0007).

CONCLUSIONS:

Age-related BP gradients vary considerably across global populations and are associated with variability in BP-related risks and adverse outcomes across regions. Effective public health strategies may require region-specific targeting of adverse BP gradients to improve health outcomes.