bluuebunny/crossref_metadata_2025 huggingface dataset:
Variations in Thalamic Anatomy Affect Targeting in Deep Brain Stimulation for Epilepsy
Authors: Wu Chengyuan , D'Haese Pierre-François , Pallavaram Srivatsan , Dawant Benoit M. , Konrad Peter , Sharan Ashwini D.
Published: November 2016

Background: Thalamic size and shape vary significantly across patients - with changes specific to the anterior thalamus occurring with age and in the setting of chronic epilepsy. Such ambiguity raises concerns regarding electrode position and potential implications for seizure outcomes. Methods: MRIs from 6 patients from a single center underwent quantitative analysis. In addition to direct measurements from postimplantation MRIs, the CRAnialVault Explorer suite was used to normalize electrode position to a common reference system. Relationships between thalamic dimensions, electrode location, and seizure outcome were analyzed. Results: Although this study group was too small to sufficiently power statistical analysis, general trends were identified. There was a trend towards smaller thalamic volumes in nonresponders. Electrode locations demonstrated more variation after normalization. There was a trend towards a more lateral, posterior, and inferior electrode position in nonresponders. Conclusions: Variations in thalamic shape and volume necessitate direct targeting. Given that changes occur to thalamic anatomy with age and in the setting of epilepsy, improved methods for visualizing and targeting the anterior nucleus are necessary. Pronounced thalamic atrophy may preclude proper electrode placement and serve as a poor prognostic indicator. A greater understanding of thalamic anatomy and connectivity is necessary to optimize deep brain stimulation for epilepsy.
Identifying Gene Signature for the Detection of Ovarian Cancer Based on the Achieved Related Genes
Authors: Wang Liangliang , Wang Lihua , Ma Ling , Liu Jingbo , Ma Shanshan
Published: November 2016

Background: The overall survival rate of ovarian cancer patients is still poor because of the difficulties encountered in detection, diagnosis and treatment. Here, we aim to systematically identify the genetic factors causing ovarian cancer and find the accurate diagnostic and therapeutic targets for ovarian cancer. Methods: We collected the known archived ovarian cancer-related genes from the databases used as the investigated targets and employed the minimum redundancy maximum relevance and random forest classification to identify the novel ovarian cancer-related genes in addition to the known ones. We further identified candidates as the markers for the detection of the ovarian cancer based on the gene expression data and then confirmed them by quantitative real-time PCR. Results: We found out the genetic terms to interpret the mechanism of ovarian cancer. Based on those terms, we predicted 860 novel related genes as candidates. These candidates can act as expression biomarkers for clinical detection and they achieved a 100% accuracy. We verified 10 of them as the optimal biomarkers for detection in the expression data. Conclusion: We employed the features of achieved ovarian cancer-related genes to identify 860 novel ovarian cancer genes. We further validated 10 genes as biomarkers for detection of ovarian cancer.
A First Evaluation of OMNI®, A New Device for Continuous Renal Replacement Therapy
Authors: Schläpfer Pierre , Durovray Jean-Daniel , Plouhinec Valery , Chiappa Cristiano , Bellomo Rinaldo , Schneider Antoine
Published: November 2016

Background: Omni® (B. Braun, Germany) is a new-generation, continuous renal replacement therapy (CRRT) machine designed to improve user interface, minimize downtime and optimize renal dose delivery. It was never tested in humans. Methods: We used Omni® to provide CRRT in 10 critically ill patients. We collected therapy data, metabolic parameters and evaluated user's satisfaction with a survey. Results: CRRT was delivered using Omni® in CVVH-heparin (6 patients) and CVVHD-citrate (4 patients) modes for a total duration of 617.7 h. No adverse event was observed. The mean filter life was 22.8 (CVVH-heparin) and 33.5 (CVVHD-citrate) h. Alarms-related downtime corresponded to 5.9% of total therapy time. Delivered renal dose was 96.6% of prescribed. Satisfactory metabolic control and fluid removal were achieved. Overall, users evaluated interface, design and usability as excellent. Conclusion: CRRT in CVVH-heparin and CVVHD-citrate modes was provided using Omni® in a safe and efficient way for 10 critically ill patients. Video Journal Club ‘Cappuccino with Claudio Ronco' at http://www.karger.com/?doi=451053.
Minocycline Suppresses NLRP3 Inflammasome Activation in Experimental Ischemic Stroke
Authors: Lu Yunnan , Xiao Guodong , Luo Weifeng
Published: November 2016

Objective: Minocycline, a tetracycline antibiotic, has shown anti-inflammatory effects in cerebral ischemia and neurodegenerative disease; however, the molecular mechanisms underlying this effect have not been clearly identified. Since NLRP3 inflammasome activation controls the maturation and release of proinflammatory cytokines, especially interleukin-1β (IL-1β) and IL-18 in ischemia stroke, we suppose that minocycline may be involved in the regulation of NLRP3 inflammasome activation. Methods: We investigated the effects of minocycline on NLRP3 inflammasome activation using the transient middle cerebral artery occlusion (tMCAO) mouse model and an in vitro oxygen-glucose deprivation/reoxygenation injury model in BV2 microglial cells. Results: We found that minocycline administrated 1 h after reperfusion can improve neurological disorder, reduce infarct volume, and alleviate cerebral edema. Meanwhile, we showed that minocycline prevented the activation of microglias and attenuated NLRP3 inflammasome signaling after tMCAO injury. Furthermore, we found that the pretreatment of minocycline significantly inhibited signal 1 and signal 2 of NLRP3 inflammasome activation in BV2 cells. Conclusion: We demonstrated that minocycline can ameliorate ischemia-induced brain damage via inhibiting NLRP3 inflammasome activation.
Analysis on the Polymorphism of Chromosome Region 9p21 and the Susceptibility of Carotid Plaque
Authors: Sun Jialan , Sun Fenghua , Yang Kang , Fu Ningzhen , Li Longxuan
Published: November 2016

Background: Atherosclerosis is a complicated disease governed by genetic, environmental and vascular risk factors, while its relationship with specific genes is still unclear. In recent days, it has been discovered that the single-nucleotide polymorphisms of chromosomal region 9p21 were relevant with the genetic susceptibility of Atherosclerosis. We aimed to figure out the relativity between the gene polymorphism of region 9p21 (rs10757274, rs7044859, rs4977574 and rs496892) and carotid plaque. Methods: With polymerase chain reaction-ligase detection reaction, the gene polymorphisms of site rs10757274, rs7044859, rs4977574 and rs496892 in chromosome region 9p21 were analyzed in 764 non-cardiac cerebral infarction (CI) patients (406 with carotid plaque while 358 without). Results: Among the population aged between 45 and 65, compared to patients without carotid plaque, no significant difference were observed on the genotype or allele frequencies distribution in 9p21 genes including rs10757274, rs7044859, rs4977574 and rs496892 in the patients with carotid plaque. There existed strong linkage disequilibrium not only between rs10757274 and rs4977574 but also between rs7044859 and rs496892 as well. Conclusion: In Chinese Han CI population, there was no significant relevance between the polymorphisms of site rs10757274, rs7044859, rs4977574 and rs496892 in region 9p21 and the susceptibility of carotid plaque.
Progression of Carotid Arterial Stiffness With Treatment of Hypertension Over 10 Years
Authors: Gepner Adam D. , Tedla Yacob , Colangelo Laura A. , Tattersall Matthew C. , Korcarz Claudia E. , Kaufman Joel D. , Liu Kiang , Burke Gregory L. , Shea Steven , Greenland Philip , Stein James H.
Published: November 2016

Associations with antihypertensive medication classes and progression of arterial stiffness have not been studied in a prospective multiethnic cohort. All participants had hypertension at baseline, defined as blood pressure ≥140/90 mm Hg or use of antihypertensive medications. Medication use and blood pressure were assessed at 5 time points. Young’s elastic modulus and distensibility coefficient of the right common carotid artery were obtained by ultrasound at baseline and after a mean (SD) follow-up period of 9.4 (0.5) years. Associations with changes in Young’s elastic modulus and distensibility coefficient, baseline antihypertensive medication use, number of visits each medication class was reported, and blood pressure control (<140/90 mm Hg) were assessed using multiple linear regression models. At baseline, mean age of participants (n=1206) was 63.2 (9.0) years (55% female; 35% African American, 19% Hispanic, 12% Chinese). Mean systolic blood pressure was 136.5 (20.6) mm Hg. Greater progression of arterial stiffness was associated with older age, African American ethnicity, and baseline calcium channel blocker use. There were no other associations between changes in Young’s elastic modulus or distensibility coefficient and use of other medication classes (all
P
>0.4). Achieving blood pressure control (<140/90 mm Hg) at all visits was associated with slower progression of arterial stiffness (Young’s elastic modulus: β=−790.1 mm Hg,
P
=0.01; distensibility coefficient: β=7.34×10
−
4
mm Hg
−
1
,
P
=0.001). Blood pressure control, rather than use of any particular antihypertensive medication class, was associated most strongly with slowing arterial stiffness progression. Over nearly a decade of follow-up, no consistent associations between any specific antihypertensive medication class and progressive carotid arterial stiffening were identified.
Religious Mahbär in Ethiopia: Ritual Elements, Dynamics, and Challenges
Authors: Flemmen Anne Britt , Zenebe Mulumebet
Published: November 2016

This article explores the religious associationmahbär, also calledtsïwwa, in Ethiopia. Data from lay practitioners as well as priests show that religious mahbär has many religious as well as social functions. It is a ritual with long traditions in the Ethiopian OrthodoxTäwahedoChurch. The authors show that what characterizes mahbär as a ritual is its unusual richness, complexity, multifunctionality and flexibility. By placing it within the Ethiopian religious context and the present development, the authors discuss why religious mahbär is in decline despite its multiple functions, flexibility, and support from the Ethiopian OrthodoxTäwahïdoChurch. In difficult economic times one would expect traditional rituals such as mahbär to become more important to people, and hence to be strengthened, but this does not seem to be the case here. In the authors’ view, three factors are pushing this decline: economic challenges, time constraints, and member recruitment.
Jesus’ Table Fellowship with “Toll Collectors and Sinners”
Authors: Wassen Cecilia
Published: November 2016

Jesus’ attitude towards purity practices is a hotly debated issue. The majority of scholars argue that Jesus challenged purity halakhah in some way. One of the proofs cited to support the position that Jesus allegedly disregarded purity laws is that he ate with “tax collectors and sinners.” Whereas purity concerns are not explicit on the story level in the texts, many scholars still find Jesus’ actions contradictory to the norms. This paper discusses if purity plays a part, and if so how, in Jesus’ sharing meals with people considered sinners. As I will show, purity concerns only play a minor role in Jesus’ meal practice and there is nothing in his behaviour that indicates that he somehow challenged purity norms, only social norms.
Biological Parenting as a Human Right
Authors: Liao S. Matthew
Published: November 2016

Do biological parents have the right to parent their own biological children? It might seem obvious that the answer is yes, but the philosophical justification for this right is uncertain. In recent years, there has been a flurry of philosophical activity aimed at providing fresh justifications for this right. In this paper, I shall propose a new answer, namely, the right to parent one’s own biological children is a human right. I call this the human rights account of parental rights and I shall explain how this account is better than these other alternatives.
Erasmus Openeth the Way Before Luther
Authors: Whitford David M.
Published: November 2016

An examination of the role of Humanisim, via Lefèvre and Erasmus on the formation of Martin Luther’s theology leading up to the Ninety-Five Theses.
Erasmus’s Biblical Project
Authors: Nellen Henk , Bloemendal Jan
Published: November 2016

The history of the immediate response on and later reception of Erasmus’s ‘New Testament Project’ is an eventful one. The Project consisted of three innovations in biblical scholarship: the first printed edition of the Greek text of the New Testament, a revised version of the Latin Vulgate, and a philological commentary that accounted for the many textual changes the translator had made. The article discusses the polemics Erasmus’s edition provoked immediately after publication in 1516, and sheds light on the influence his Project exerted in later centuries. Special attention is given to biblical passages that played an important role in the discussions on the doctrine of the Trinity, such as Rom. 9,5; 1 Joh. 5,7–8 (the famous Comma Johanneum), and 1 Tim. 3,16. In questioning these passages as convincing, irrefutable proof-texts of Christ’s divinity, Erasmus made himself vulnerable to accusations of reviving Arianism, an old anti-Trinitarian heresy.
Equiseticola gen. nov. (Phaeosphaeriaceae), from Equisetum sp. in Italy
Authors: ABD-ELSALAM KAMEL A , TIBPROMMA SAOWALUCK , WANASINGHE DHANUSHKA N. , CAMPORESI ERIO , Hyde Kevin D.
Published: November 2016

This paper reports an interesting saprobic ascomycete which was collected and isolated from Equisetum sp. in Italy. The phylogeny of this taxon and genera of Phaeosphaeriaceae are constructed based on analyses of combined LSU, SSU and ITS sequence data. The species has exclusive characters such as ovoid ascomata with minute papilla, cylindrical asci with long acute or knob-like pedicel and fusiform, 4–5-septate, yellowish to pale brown ascospores. Based on phylogeny and morphology we introduce the taxon as a new genus and species within Phaeosphaeriaceae. The new genus and species are introduced with an illustrated account and compared with other taxa in Phaeosphaeriaceae.
The type specimen and generic placement of Tridactylus galla Saussure, 1895 (Orthoptera: Caelifera: Tridactylidae)
Authors: HEADS SAM W. , HOLLIER JOHN
Published: November 2016

Tridactylus galla was described by Henri de Saussure (1895) on the basis of a single adult female collected during Vittorio Bottego’s first expedition to the Horn of Africa in 1892 and 1893. The species appears in lists compiled by Fenizia (1896), Lucas (1898) and Kirby (1906), but aside from a brief mention by Günther (1995), is entirely overlooked by subsequent authors and is absent from Otte’s (1997) catalogue. During the course of compiling an annotated catalogue of the Orthoptera described by Saussure (Hollier and Heads, 2012) we were able to relocate the type of Tridactylus galla in the collection of the Museo Civico di Storia Naturale “Giacomo Doria” in Genova, Italy. Our examination of the specimen confirmed Günther’s (1995) assertion that its placement in Tridactylus Olivier, 1789 is erroneous, and the species is herein formally transferred to the genus Xya Latreille, 1809.
Observing and Predicting the 2015/16 El Niño
Authors: L’Heureux Michelle L. , Takahashi Ken , Watkins Andrew B. , Barnston Anthony G. , Becker Emily J. , Di Liberto Tom E. , Gamble Felicity , Gottschalck Jon , Halpert Michael S. , Huang Boyin , Mosquera-Vásquez Kobi , Wittenberg Andrew T.
Published: November 2016

The El Niño of 2015/16 was among the strongest El Niño events observed since 1950 and took place almost two decades after the previous major event in 1997/98. Here, perspectives of the event are shared by scientists from three national meteorological or climate services that issue regular operational updates on the status and prediction of El Niño–Southern Oscillation (ENSO). Public advisories on the unfolding El Niño were issued in the first half of 2015. This was followed by significant growth in sea surface temperature (SST) anomalies, a peak during November 2015–January 2016, subsequent decay, and its demise during May 2016. The life cycle and magnitude of the 2015/16 El Niño was well predicted by most models used by national meteorological services, in contrast to the generally overexuberant model predictions made the previous year. The evolution of multiple atmospheric and oceanic measures demonstrates the rich complexity of ENSO, as a coupled ocean–atmosphere phenomenon with pronounced global impacts. While some aspects of the 2015/16 El Niño rivaled the events of 1982/83 and 1997/98, we show that it also differed in unique and important ways, with implications for the study and evaluation of past and future ENSO events. Unlike previous major El Niños, remarkably above-average SST anomalies occurred in the western and central equatorial Pacific but were milder near the coast of South America. While operational ENSO systems have progressed markedly over the past several decades, the 2015/16 El Niño highlights several challenges that will continue to test both the research and operational forecast communities.
Is it ok to care? How compassion falters and is courageously accomplished in the midst of uncertainty
Authors: Kanov Jason , Powley Edward H , Walshe Neil D
Published: November 2016

This article elaborates the organizational literature’s process theory of compassion – an empathic response to suffering – which falls short of adequately explaining why and how compassion unfolds readily in some workplace situations or settings but not in others. We address this shortcoming by calling attention to the basic uncertainty of suffering and compassion, demonstrating that this uncertainty tends to be particularly pronounced in organizational settings, and presenting propositions that explain how such uncertainty inhibits the compassion process. We then argue that understanding the accomplishment of compassion in the midst of uncertainty necessitates regarding compassion as an enactment of courage, and we incorporate insights from the organizational literature on everyday courageous action into compassion theory. We conclude with a discussion of implications in which we underscore the importance of organizational support for the expression of suffering and the doing of compassion, and we also consider directions for future research.
A realist alternative to meta-analysis: Two papers
Authors: Edwards Paul K
Published: November 2016

Meta-analysis (the statistical combination of a set of studies in a given area, with the aim of establishing an overall or average effect of something) is increasingly common in work and organization studies. Critiques of meta-analysis are now common. There is also a well-known alternative based in realism. The purpose in bringing together the two papers by Nielsen and Miraglia and by Vincent and colleagues is not to rehearse the critiques or simply explain realism or realist evaluation. The two papers certainly perform these functions in setting out problems with meta-analysis and also identifying when and to what extent it remains valid. The goal, however, is to move forward by showing what a realist synthesis would look like and illustrating how it works. Vincent and colleagues lay out the principles, while Nielsen and Miraglia take the case of intervention studies to show how realist evaluation works.
Beneath the white gaze: Strategic self-Orientalism among Chinese Australians
Authors: Liu Helena
Published: November 2016

This article analyses the ethno-cultural identities of Chinese Australian professionals through a postcolonial lens. Drawing on in-depth interviews with 21 participants, it explores how they engaged in self-Orientalism; casting themselves as exotic commodities for the benefit of white people and institutions. In particular, they enacted Chinese stereotypes through ‘mythtapping’ and ‘mythkeeping’ in order to secure recognition under the white gaze. As mythtappers, professionals presented themselves as custodians of an ancient and mysterious culture that offered organizational wisdoms for ‘the West.’ As mythkeepers, the professionals allayed white anxieties by surrendering themselves to white Australians as pathways into their communities. However, the professionals’ Orientalized identities are not passively determined, but are in some cases tactically and strategically resisted through ‘mythbusting.’ The article contributes to postcolonial theorizing by demonstrating how imperialist ideologies constrain the lives of people beyond the colonizer/colonized dichotomy and by illuminating the potential for their resistance against Orientalization.
Insulin-Like Growth Factor-1–Mediated DNA Repair in Irradiated Salivary Glands Is Sirtuin-1 Dependent
Authors: Meyer S. , Chibly A.M. , Burd R. , Limesand K.H.
Published: November 2016

Ionizing radiation is one of the most common cancer treatments; however, the treatment leads to a wide range of debilitating side effects. In patients with head and neck cancer (HNC), the surrounding normal salivary gland is extremely sensitive to therapeutic radiation, and damage to this tissue results in various oral complications and decreased quality of life (QOL). In the current study, mice treated with targeted head and neck radiation showed a significant increase in double-stranded breaks (DSB) in the DNA of parotid salivary gland cells immediately after treatment, and this remained elevated 3 h posttreatment. In contrast, mice pretreated with insulin-like growth factor-1 (IGF-1) showed resolution of the same amount of initial DNA damage by 3 h posttreatment. At acute time points (30 min to 2 h), irradiated parotid glands had significantly decreased levels of the histone deactylase Sirtuin-1 (SirT-1) which has been previously shown to function in DNA repair. Pretreatment with IGF-1 increased SirT-1 protein levels and increased deacetylation of SirT-1 targets involved in DNA repair. Pharmacological inhibition of SirT-1 activity decreased the IGF-1–mediated resolution of DSB. These data suggest that IGF-1 promotes DNA repair in irradiated parotid glands through the maintenance and activation of SirT-1.
Sphingomyelin Phosphodiesterase 3 Enhances Cytodifferentiation of Periodontal Ligament Cells
Authors: Miyauchi S. , Kitagaki J. , Masumoto R. , Imai A. , Kobayashi K. , Nakaya A. , Kawai S. , Fujihara C. , Asano Y. , Yamashita M. , Yanagita M. , Yamada S. , Kitamura M. , Murakami S.
Published: November 2016

Sphingomyelin phosphodiesterase 3 ( Smpd3), which encodes neutral sphingomyelinase 2 (nSMase2), is a key molecule for skeletal development as well as for the cytodifferentiation of odontoblasts and alveolar bone. However, the effects of nSMase2 on the cytodifferentiation of periodontal ligament (PDL) cells are still unclear. In this study, the authors analyzed the effects of Smpd3 on the cytodifferentiation of human PDL (HPDL) cells. The authors found that Smpd3 increases the mRNA expression of calcification-related genes, such as alkaline phosphatase (ALPase), type I collagen, osteopontin, Osterix (Osx), and runt-related transcription factor (Runx)-2 in HPDL cells. In contrast, GW4869, an inhibitor of nSMase2, clearly decreased the mRNA expression of ALPase, type I collagen, and osteocalcin in HPDL cells, suggesting that Smpd3 enhances HPDL cytodifferentiation. Next, the authors used exome sequencing to evaluate the genetic variants of Smpd3 in a Japanese population with aggressive periodontitis (AgP). Among 44 unrelated subjects, the authors identified a single nucleotide polymorphism (SNP), rs145616324, in Smpd3 as a putative genetic variant for AgP among Japanese people. Moreover, Smpd3 harboring this SNP did not increase the sphingomyelinase activity or mRNA expression of ALPase, type I collagen, osteopontin, Osx, or Runx2, suggesting that this SNP inhibits Smpd3 such that it has no effect on the cytodifferentiation of HPDL cells. These data suggest that Smpd3 plays a crucial role in maintaining the homeostasis of PDL tissue.
Sudden death by rupture of a varicose vein: Case report and review of literature
Authors: Aquila Isabella , Sacco Matteo A , Gratteri Santo , Di Nunzio Ciro , Ricci Pietrantonio
Published: November 2016

Venous disease, including varicose veins and chronic venous insufficiency, is one of the most common chronic medical conditions. Haemorrhage from rupture of varicose veins in the legs is rare and can lead to sudden death. Nevertheless, this condition is not included among the causes of sudden death. In this case, an 88-year-old man was found dead in a large pool of blood at home. Initially, investigators mistakenly assumed that it was a case of homicide. Bloodstain pattern analysis was performed. An external examination of the victim showed an ulcer on the left foot and evident varicose veins untreated on the lower limbs. The aim of this study is to emphasize the role of treatment of varicose veins in the prevention of adverse events such as sudden death from acute haemorrhage.
Generalized projective synchronization between controlled master and multiple slave TLFMs with modified adaptive SMC
Authors: Lochan Kshetrimayum , Roy Binoy Krishna , Subudhi Bidyadhar
Published: November 2016

The problem of projected work space trajectory synchronization for multiple two link flexible manipulators is considered here. Generalized projective synchronization between a controlled master and multiple slave manipulators is presented in this paper. The master and slave manipulators are non-identical. A low frequency chaotic signal and an exponentially varying signal are used as the desired trajectories. An equivalent sliding mode controller is designed for the master manipulator to track the desired trajectory. A modified adaptive equivalent sliding mode controller is designed for the slave manipulators to be projectively synchronized with the controlled master. Two scaling factors are used for the projective synchronization. Simulation results, with disturbances and payload variation reveal that the master and multiple slaves are synchronized with their respective desired trajectories. Such projective synchronization between one master and multiple slaves using the proposed control techniques to track a low frequency chaotic desired signal is not found in the literature. Such projective synchronization to track a chaotic signal is considered as the novelty of this paper. The performances of the proposed control techniques are found to be better in terms of link deflections and control effort when compared with three other sliding mode control techniques.
System identification: Parameter and time-delay estimation for Wiener nonlinear systems with delayed input
Authors: Atitallah Asma , Bedoui Saïda , Abderrahim Kamel
Published: November 2016

In this paper, a novel optimization approach to estimate the time delay and the parameters of Wiener time-delay systems is proposed. The proposed method consists first in defining a cost function and second in selecting an appropriate algorithm to solve it. However, any used cost function for the purpose of Wiener time-delay system identification presents several difficulties in terms of nonlinearity and inaccessible measurements. In fact, the hierarchical approach, the rounding property and the auxiliary model approach are suggested as solutions to overcome these difficulties. These solutions allow us to transform the cost function to be minimized into two simple cost functions that are minimized using the conjugate gradient algorithm with different choices of its main parameters. Simulation results are presented to illustrate the performance of the proposed approach.
A lost track in ICHD 3 beta: A comprehensive review on osmophobia
Authors: Zanchin Giorgio , Fuccaro Matteo , Battistella Pierantonio , Ermani Mario , Mainardi Federico , Maggioni Ferdinando
Published: November 2016

Background

Osmophobia (Os) has been reported to be much more prevalent in migraine (M) than in other primary headaches, and its high specificity in the differential diagnosis between M and tension-type headache (TTH) has been reported. Os was included in the ICHD II Appendix as a diagnostic criterion of M. It disappeared in ICHD-3 beta. To understand this choice, we reviewed the literature after 2004.

Methods

This was a systematic review. We searched in PubMed, MEDLINE and Cochrane library for “osmophobia”, “odour/odorphobia AND headache”, “odour/odor hypersensitivity AND headache” and “olfactory hypersensitivity AND headache”.

Results

112 papers cited Os as an accompanying symptom of headache; 16 focused on Os in M diagnosis. With the data from 40 articles, we calculated the pooled prevalence of Os in 14,360 patients (2281 pediatric) affected by M (n = 12,496) and TTH (n = 1864). In M, the prevalence was 48.5% (CI 95% 41.4 to 55.8%) in adults and 23.4% (CI 95% 15.7 to 33.4%) in pediatric patients; in TTH, the prevalence was 8.9% (CI 95% 4.6 to 13.5%) in adults and 7.9% (CI 95% 3.3 to 18.1%) in pediatric patients. Ten of these papers allowed us to calculate the sensibility and specificity of Os in differential diagnosis between M and TTH. In adults, the value of specificity was 94.1% (CI 95% 88.9 to 96.9%), and sensitivity was 51.4% (CI 95% 38.4 to 64.2%). In pediatric patients, specificity was 92.0% (CI 95% 81.9 to 96.7%), and sensitivity was 22.1% (CI 95% 10.1 to 41.8%).

Conclusion

The literature endorses the inclusion of Os among M diagnostic criteria. On this ground, the decision to remove Os from ICHD 3 beta appears unjustified and a revision of this choice is recommended.
Trigger points are associated with widespread pressure pain sensitivity in people with tension-type headache
Authors: Palacios-Ceña María , Wang Kelun , Castaldo Matteo , Guillem-Mesado Amparo , Ordás-Bandera Carlos , Arendt-Nielsen Lars , Fernández-de-las-Peñas César
Published: November 2016

Objective

To investigate the association between trigger points (TrPs) and widespread pressure pain sensitivity in people with tension-type headache (TTH) and to determine if this association is different between frequent episodic (FETTH) or chronic (CTTH) headache.

Design

A cross-sectional study.

Methods

One hundred and fifty-seven individuals (29% male) with TTH participated. Clinical features of headache, i.e., intensity, duration, and frequency, were recorded in a headache diary. Active and latent TrPs were bilaterally explored in the temporalis, masseter, suboccipital, upper trapezius, sternocleidomastoid, and splenius capitis muscles. Pressure pain thresholds (PPT) were assessed over the trigeminal area (i.e., temporalis muscle), extra-trigeminal (i.e., C5/C6 zygapophyseal joint), and two distant pain-free points (i.e., second metacarpal and tibialis anterior muscle).

Results

Eighty (51%) patients were classified as FETTH, whereas 77 (49%) were classified as CTTH. No differences in the number of either active or latent TrPs (all p > 0.171) or widespread pressure pain sensitivity (all p > 0.351) were observed between FETTH and CTTH groups. The number of active and latent TrPs was significantly and negatively associated with PPTs: The higher the number of active or latent TrPs, the lower the widespread PPT, and the more generalized sensitization. This association was stronger within the FETTH group than the CTTH group.

Conclusions

This study found that the number of TrPs in head and neck/shoulder muscles was associated with widespread pressure hypersensitivity independently of the frequency of headache.
Designing of an electromagnetic driver for the reversing valve of CNC die forging hammer
Authors: Zhu Muzhi , Liang Jintao , Zhao Shengdun
Published: November 2016

This paper is aimed at the solution of the driving actuator of the reversing valve, which is the core component of CNC die forging hammer. The proposed electromagnetic drive method contributes to a precise control of the valve spool position and eliminates the transmission mechanism and hydraulic circuits. The complete structure and the topology structure of the electromagnetic part are designed to guarantee its high controllability and robustness. The structure parameters of the electromagnetic part are calculated based on the driving requirement of the reversing valve. With the finite element analysis of the direct driving part, saturation phenomenon of the magnetic circuit is eliminated and optimization of the output force ripple is performed. The output force of the electromagnetic part is simulated to reach 1000 N with a rated speed of 0.55 m/s, which satisfies the drive demand of the reversing valve spool and the ripple amplitude of the output force is reduced by 43.9%. The operational test of the electromagnetic direct drive component is conducted to verify the finite element method simulation method and shows an expected performance.
Economic renewal through devolution? Tax reform and the uneven geographies of the economic dividend
Authors: Bailey Daniel
Published: November 2016

The economic governance of the UK is currently in flux with various devolution agreements being negotiated across the country. This article examines the changing political economy of the UK enforced by Wave 1 City Deals, to analyse the claims made by devolution proponents that there is an ‘economic dividend’ to devolution. The argument is made that scant evidence exists to suggest that these reforms respond to the pathologies of the UK economy. Instead, the Northern Powerhouse discourse serves to disguise the implementation of a tax and investment settlement which regressively concentrates taxation revenue in the more affluent parts of the country. These reforms though are a political expression of a certain understanding of wealth creation which privileges low tax taxation, inter-territorial competition to promote it and a belief in the major UK cities to drive the economic recovery. It is a strategy likely to produce very uneven geographies of growth which will exacerbate uneven development; ironically so given the ‘Northern Powerhouse’ rhetoric through which it was reasoned.
Toward a User-Centered Approach for Emergency Warning Distribution
Authors: Schroeder Bradford L. , Whitmer Daphne E. , Sims Valerie K.
Published: November 2016

There are many known problems with inappropriate response to emergency warnings. Recommended actions are not always properly followed, and sometimes emergency warnings are not taken seriously. A variety of psychological individual differences can influence the perception of emergency warnings. At present, warning distributors do not consider how these factors affect emergency warning response. We recommend that emergency warning distribution systems be developed that account for these differences to improve response. To this end, we propose four guidelines supported by psychological research and inspired by currently available technologies. These guidelines frame a user-centered approach to more appropriately tailor warning messages for each recipient.
Evaluating Treatment Outcomes Using the Integrative Model of Brief Couples Counseling
Authors: Gutierrez Daniel , Carlson Ryan G. , Daire Andrew P. , Young Mark E.
Published: November 2016

Utilizing a community sample of 58 couples (116 individuals), we tested a brief couples counseling approach, the Integrative Model of Brief Couples Counseling (IMBCC). Participants received 4–6 sessions of couples counseling conducted by graduate students during their supervised field experience. We assessed participants’ marital adjustment and psychological distress at pretest and posttest. Results indicated significant decreases in psychological distress and improved marital adjustment following couples counseling utilizing the IMBCC. Further research utilizing randomized controls is suggested.
Non-linear influence of hydrostatic pressure on the yielding of asymmetric anisotropic sheet metals
Authors: Moayyedian Farzad , Kadkhodayan Mehran
Published: November 2016

The objective of the current research is the investigation into possible non-linear influence of hydrostatic pressure on yielding of asymmetric (exhibiting the so-called “strength-differential effect”) anisotropic sheet metals. To reach this aim, two yield functions are developed, called here “non-linear pressure sensitive criteria I and II,” (NPC-1 and NPC-2). In addition, the non-associated flow rules are employed for these new criteria. The yield functions are defined as non-linearly dependent on hydrostatic pressure, while the plastic potential functions are introduced to be pressure insensitive. To calibrate these criteria, the yield functions need 10 directional experimental yield stresses and the plastic potential functions need eight Lankford coefficients data points. Four well-known anisotropic sheet metals with different structures, namely AA 2008-T4, a Face Centered Cubic material (FCC), AA 2090-T3, a Face Centered Cubic material (FCC), AZ31, a hexagonal closed packed material (HCP) and high-purity [Formula: see text]-titanium (HCP) are considered as case studies. Finally, it is observed that NPC-1 and NPC-2 are more successful than previous criteria in anticipating directional strength and mechanical properties.
Sexual functioning in multiple sclerosis: Relationships with depression, fatigue and physical function
Authors: Young Carolyn A , Tennant Alan ,   on Behalf of the TONiC Study Group, Mills RJ , Rog DJ , Ford HL , Orchard K
Published: November 2016

Background:

Sexual dysfunction (SD) is common among people with multiple sclerosis, but there is limited information on its relationships.

Objective:

This national study examines the relationships between sexual function with demographic factors, physical function, fatigue and depression.

Methods:

Participants in the Trajectories of Outcomes in Neurological Conditions (TONiC) study completed the measures of fatigue, physical function and depression together with the Multiple Sclerosis Intimacy and Sexuality Questionnaire-15 (MSISQ-15), which covers sexual function (primary), symptoms that interfere with sexual function (secondary) and psychological issues (tertiary). All ordinal scores from the measures were converted to interval scale latent estimates via the Rasch model and used as single indicator latent variables in path analysis.

Results:

From 722 patients, 538 were sexually active of whom 431 (80.1%) answered questions on sexual functioning. Of these, only 18.5% reported no impact on any aspect of sexual function. Dysfunction was linked to disease subtype and Expanded Disability Status Scale (EDSS). Subtype influenced the relationship between symptoms and sexual function, which was fully mediated by psychological factors in secondary progressive patients. Depression was not directly associated with sexual functioning, but appeared as a consequence of the psychological issues associated with SD.

Conclusion:

SD is common among participants in this UK-wide study, and psychological aspects of SD contributed to depression.
Drawing the answers: Sketching to support free and probed recall by child witnesses and victims with autism spectrum disorder
Authors: Mattison Michelle , Dando Coral J , Ormerod Thomas C
Published: November 2016

The success of witness interviews in the criminal justice system depends on the accuracy of information obtained, which is a function of both amount and quality of information. Attempts to enhance witness retrieval such as mental reinstatement of context have been designed with typically developed adults in mind. In this article, the relative benefits of mental and sketch reinstatement mnemonics are explored with both typically developing children and children with autism. Children watched a crime event video, and their retrieval of event information was examined in free and probed recall phases of a cognitive interview. As expected, typically developing children recalled more correct information of all types than children with autism during free and probed recall phases. Sketching during free recall was more beneficial for both groups in both phases in reducing the amount of incorrect items, but the relative effect of sketching on enhancing retrieval accuracy was greater for children with autism. The results indicate the benefits of choosing retrieval mnemonics that are sensitive to the specific impairments of autistic individuals and suggest that retrieval accuracy during interviews can be enhanced, in some cases to the same level as that of typically developing individuals.
Meta-analysis of parent-mediated interventions for young children with autism spectrum disorder
Authors: Nevill Rose E , Lecavalier Luc , Stratis Elizabeth A
Published: November 2016

A number of studies of parent-mediated interventions in autism spectrum disorder have been published in the last 15 years. We reviewed 19 randomized clinical trials of parent-mediated interventions for children with autism spectrum disorder between the ages of 1 and 6 years and conducted a meta-analysis on their efficacy. Meta-analysis outcomes were autism spectrum disorder symptom severity, socialization, communication-language, and cognition. Quality of evidence was rated as moderate for autism spectrum disorder symptom severity, communication-language, and cognition, and very low for socialization. Weighted Hedges’ g varied from 0.18 (communication-language) to 0.27 (socialization) and averaged 0.23 across domains. We also examined the relationship between outcome and dose of parent training, type of control group, and type of informant (parent and clinician). Outcomes were not significantly different based on dose of treatment. Comparing parent training to treatment-as-usual did not result in significantly different treatment effects than when parent training was compared to an active comparison group. Based on parent report only, treatment effects were significant for communication-language and non-significant for socialization, yet the opposite was found based on clinician-rated tools. This meta-analysis suggests that while most outcome domains of parent-delivered intervention are associated with small effects, the quality of research is improving.
Limitation of computed tomography scan in ocular trauma in diagnosing posterior globe rupture and retinal detachment
Authors: Munirah AR , Safinaz MK , Aida ZMZ , Malisa A , Hazlita MI
Published: November 2016

Ocular trauma with penetrating eye injury or globe rupture is an ophthalmic emergency. Immediate but gentle ocular assessment is mandatory to diagnose the extent of the injury. Imaging modalities are valuable in aiding diagnosis and management in open globe injury due to the difficulty of full eye assessment in the presence of multiple head and facial injuries. This report presents a case of an elderly man with ocular trauma of the left only seeing eye where computed tomography scan showed anterior globe rupture and the possibility of posterior globe rupture due to discontinuity of the posterior sclera. Primary repair and exploration of the left eye revealed no posterior globe rupture. Post-operative B-scan revealed a total retinal detachment with intact posterior globe. Vision of the left eye after pars planar vitrectomy and tamponade of the retina detachment with heavy silicone oil improved to 1/60. Computed tomography scan in ocular trauma has limitations especially in diagnosing retinal detachment and posterior globe rupture.
Patient characteristics related to metabolic disorders and chronic complications in type 2 diabetes mellitus patients hospitalized at the Qingdao Endocrine and Diabetes Hospital from 2006 to 2012 in China
Authors: Dong Yanhu , Gao Weiguo , Zhang Lei , Wei Jia , Hammar Niklas , Cabrera Claudia S , Wu Xiaoli , Qiao Qing
Published: November 2016

Objective:

To study the clinical characteristics related to metabolic disorders and complications in type 2 diabetes mellitus patients hospitalized in the Qingdao Endocrine and Diabetes Hospital from 2006 to 2012 in Qingdao, China.

Patient population and methods:

Data from 14,289 (51% males) type 2 diabetes mellitus patients hospitalized between 2006 and 2012 were collected and analysed. Information on patients’ demographic, anthropometric, laboratory and disease histories were extracted from electronic medical records.

Results:

The mean age of the patients was 60.5 years, with median diabetes duration of 9.0 years. Mean haemoglobin A1c was 8.4%, where <30.0% of patients had haemoglobin A1c <7.0%. In all, 34.5% of patients had low-density lipoprotein cholesterol lower than 2.6 mmol/L and 31.9% had hypertriglyceridaemia. Retinopathy was diagnosed in 51.1% of patients, nephropathy in 21.6%, neuropathy in 50.4%, hypertension in 77.4%, coronary heart disease in 27.6% and peripheral vascular disease in 58.6%. Once hospitalized, 71.1% of patients underwent insulin injection treatments, either mono-therapy or combined with other anti-diabetic drugs. Metformin was prescribed to 36.9% of patients, followed by acarbose 29.9%, thiazolidinediones 18.1%, meglitinides 14.8% and sulfonylureas 10.7%.

Conclusion:

Inadequate control of hyperglycaemia, poor metabolic profiles and diabetic complications were common challenges for long-term diabetes management in Chinese patients with type 2 diabetes mellitus.
Graduate students’ experiences with research ethics in conducting health research
Authors: Petillion Wendy , Melrose Sherri , Moore Sharon L , Nuttgens Simon
Published: November 2016

Graduate students typically first experience research ethics when they submit their masters or doctoral research projects for ethics approval. Research ethics boards in Canada review and grant ethical approval for student research projects and often have to provide additional support to these novice researchers. Previous studies have explored curriculum content, teaching approaches, and the learning environment related to research ethics for graduate students. However, research does not exist that examines students’ actual experience with the research ethics process. Qualitative description was used to explore the research ethics review experience of 11 masters and doctoral students in health discipline programs. Data analysis revealed four themes: curriculum, supervisor support, the ethics application process, and students’ overall experience. The results of this research suggest ideas for enhancing curriculum, deepening students’ relationships with supervisors, and developing the role of research ethics boards to support education for novice researchers. This study contributes to comprehension of the research ethics experience for graduate students and what they value as new researchers.
Coresident and Noncoresident Emerging Adults’ Daily Experiences With Parents
Authors: Fingerman Karen L. , Huo Meng , Kim Kyungmin , Birditt Kira S.
Published: November 2016

Coresidence between emerging adults and parents is now common in the United States, but we know little about how coresidence influences daily experiences in these ties. Coresident ( n = 62) and noncoresident ( n = 97) emerging adults (aged 18–30) reported daily experiences with parents and mood for 7 days. During the study week, compared to offspring who lived apart from parents, coresident offspring were more likely to experience positive encounters, receive more support, wish parents would change, feel irritated, and report that their parents got on their nerves. Coresident offspring did not differ from noncoresident offspring with regard to stressful thoughts. Stressful thoughts about parents were associated with more negative daily mood; this effect did not differ for coresident and noncoresident offspring. Findings are discussed with regard to intergenerational ambivalence. In sum, coresident emerging adults were more involved with parents but not more affected by daily experiences with parents.