bluuebunny/crossref_metadata_2025 huggingface dataset:
Pharmacokinetics and bioavailability of febrifugine in rat plasma determined by UPLC-MS/MS
Authors: Lin Feifei , Wang Runrun , Du Jingye , Wen Congcong , Wang Xianqin , Jin Yongxi , Shao Lingjiu
Published: December 2024

Febrifugine, a potent quinazolinone compound derived from the Chinese herb Chang Shan (Dichroa febrifuga), exhibits diverse biological activities and has demonstrated anti-tumor effects by functioning as focal adhesion kinase (FAK) inhibitors. In this study, our objective was to establish a quantitative UPLC-MS/MS method and investigate the pharmacokinetic characteristics of febrifugine in rats following intravenous and oral administration routes. The rat tail vein was used for the collection of blood samples at designated time intervals following intravenous (2.0 mg kg−1) and oral (6.0 mg kg−1) administrations. Plasma samples were pretreated with acetonitrile as a protein precipitant and methylcytisine as an internal standard. Febrifugine concentration in rat plasma was determined using the UPLC-MS/MS method, and pharmacokinetic parameters were calculated using drug and statistics (DAS) software version for statistical analysis. The linear range of febrifugine in rat plasma was 1.5–1,500 ng mL−1, meeting the precision, recovery, and stability requirements for determination purposes. Febrifugine had a half-life (t1/2) of 3.2 ± 1.6 h after administered via intravenous route, while t1/2 was 2.6 ± 0.5 h after oral administration. The developed UPLC-MS/MS method is facile to operate while adhering to rigorous methodological verification standards, rendering it suitable for investigating the pharmacokinetics of febrifugine; and bioavailability was determined as 45.8%.
A rare case of blast injury of the chest and spine on the background of a congenital malformation in the form of a complete mirror image arrangement of internal organs
Authors:   Military Medical Clinical Center of the Northern Region, Kharkiv, Ukraine, Khoroshun E.M. ,   Kharkiv National Medical University, Ukraine, Makarov V.V. ,   Military Medical Clinical Center of the Northern Region, Kharkiv, Ukraine,   Kharkiv National Medical University, Ukraine, Nehoduiko V.V. ,   Military Medical Clinical Center of the Northern Region, Kharkiv, Ukraine,   Kharkiv National Medical University, Ukraine, Shypilov S.A. ,   Military Medical Clinical Center of the Northern Region, Kharkiv, Ukraine,   Kharkiv National Medical University, Ukraine, Tertyshnyi S.V. ,   Odesa National Medical University, Ukraine,   Military Medical Clinical Center of the Southern Region, Odesa, Ukraine, Slesarenko K.S. ,   Military Medical Clinical Center of the Southern Region, Odesa, Ukraine,   Dnipro State Medical University, Ukraine
Published: December 2024

The aim is to demonstrate a clinical case of blast injury of the chest and spine against the background of a complete mirror image arrangement of internal organs.
Clinical case. The injured S., 37 years old, received a blast injury during mortar shelling. Upon admission, the injured person complained of aching pain in the area of the X rib on the left and in the lumbar region. The pain worsened during movement. He has known about the malformations of internal organs since childhood, but only about the right-sided location of the heart. The final established diagnosis is combined blast injury of the chest and spine. Closed chest injury on the left, closed fracture of the X rib on the left. Closed fracture of the lumbar processes L3-4 on the right. Congenital malformation. A complete mirror image arrangement of internal organs. The injured person was taken to a territorial hospital base for further treatment, where he received painkillers, anti-inflammatory therapy, and prescribed multivitamins. The total bed-day was 7 days. The injured was taken to the Military Medical Commission and discharged in satisfactory condition to implement the decision of the Military Medical Commission.
Conclusions. A congenital malformation in the form of a complete mirror image arrangement of internal organs is a rare pathology. Diagnosing a complete mirror image arrangement of internal organs is not difficult and is an accidental finding during the examination for the injury in this case. Anamnestic data help in the diagnostic search.
The research was carried out in accordance with the principles of the Declaration of Helsinki. The research protocol was approved by the Local Ethics Committee of a participating institution. The informed consent of the patient was obtained for conducting the studies.
No conflict of interests was declared by the authors.
The paradigm of anthropocentrism in contemporary pediatric surgery
Authors:   Poltava State Medical University, Poltava, Ukraine, Dubinina V.О. , Ksonz І.V. ,   Poltava State Medical University, Poltava, Ukraine, Bilash S.М. ,   Poltava State Medical University, Poltava, Ukraine, Abyzova L.V. ,   Poltava State Medical University, Poltava, Ukraine, Bilanov О.S. ,   Poltava State Medical University, Poltava, Ukraine
Published: December 2024

The idea of anthropocentrism is a key marker of the state of medical theory and practice in the technocratic society of the twenty-first century and demonstrates the global reflection of human society on its axiological attitudes.
Aim. The paper aims at theoretical and methodological analysis of the paradigmatic dimensions of anthropocentrism in pediatric surgery.
The theoretical basis of the study was formed by philosophical concepts of anthropocentric orientation, modern scientific substantiation of the problems of deontology and medical education. The methodology of the study was determined by the cultural approach based on the use of philosophical hermeneutics (interpretation of texts). The method of extrapolation allowed the use of philosophical heritage to analyze contemporary deontological issues. The method of synergetics provided an integrating function. The methods of analysis, synthesis, and generalization determined the logic of our scientific research.
Anthropocentrism is one of the leading trends in philosophy, which, at different historical stages, from ancient times to the present, defines topical issues, including deontological ones. Subject-object relations in medicine are relations in the “person-to-person” and “healthcare professional-to-patient” systems. The current and most realistic model is the contractual model, in which pediatric surgeons, parents of patients, and patients themselves establish relationships that are most acceptable to all participants in the treatment process.
Conclusions. The obtained results provide a more advanced level of analysis of both general and specific cognitive interests and preferences of pediatric surgery professionals from the angle of cognitions that characterize the discourse of the idea of anthropocentrism. The practical significance of the study is determined by the possibility of using the material of the paper in teaching deontological disciplines and as a factor that motivates medical students to scientific and worldview reflection.
No conflict of interests was declared by the authors.
Morphofunctional characteristics of the wound process during the treatment of purulous-necrotic wounds in rats with modern antiseptic means and collagenase
Authors:   National Pirogov Memorial Medical University, Vinnytsya, Ukraine, Rautskis V.P. , Khimich S.D. ,   National Pirogov Memorial Medical University, Vinnytsya, Ukraine
Published: December 2024

Infected and purulent wounds remain both a medical and economic challenge for the healthcare system today. Scientific and practical interest leads to the use of collagenase enzyme in wound care products.
Aim: to study and evaluate morphological changes in the wound process during the treatment of purulent-necrotic wounds in rats with drugs based on modern antiseptics and collagenase.
Materials and methods. The object of study: purulent-necrotic wounds. The experimental study was performed on 64 white laboratory rats. The simulated wound was contaminated with a pathogenic strain of S. aureus in combination with P. aeruginosa. Rats were divided into 4 groups of 16 animals each: I - control group (without treatment); II - collagenase-based gel with myramistin was used to treat the wound; III - ointment based on chloramphenicol and methyluracil; IV - myramistin-based ointment. 2 days after the start of the experiment, the drug and an aseptic gauze bandage were applied to the wound surface of animals of the II, III and IV groups, in the control group - only an aseptic bandage was applied. The dressing was changed daily for 14 days in all animals. Tissues were collected for histological and morphometric examination by excision of a fragment of skin with underlying tissues from the location of the wound defect followed by fixation in a 10% solution of neutral buffered formalin. The prepared histological sections with a thickness of 4 μm were stained with hematoxylin and eosin.
Results. It was found that in the II group, where collagenase was used, the number of leukocyte elements at the bottom of the wound defect from the 3rd day was significantly lower than in other groups. At the same time, the vascular component progressively increased. The obtained data correlate with the results of a histological examination: a faster reduction of the inflammatory process and the development of epithelialization. Complete coverage of the wound surface with the newly formed epithelium occurred already on the 10th day.
Conclusion. The obtained data indicate the appropriateness of collagenase in the treatment of purulent wounds not only as an enzymatic debridement, but as a substrance affecting important aspects in the first and second phases of the wound process.
The experiments with laboratory animals were provided in accordance with all bioethical norms and guidelines.
No conflict of interests was declared by the authors.
Surgical treatment of megaduodenum in children who underwent correction of duodenal atresia in the neonatal period
Authors:   Center for neonatal surgery for malformations and their rehabilitation of SI «Institute of Pediatrics, Obstetrics and Gynecology named after academician O.M. Lukyanova of the NAMS of Ukraine», Kyiv, Sliepov O.K. , Kotsovsky V.V. ,   Center for neonatal surgery for malformations and their rehabilitation of SI «Institute of Pediatrics, Obstetrics and Gynecology named after academician O.M. Lukyanova of the NAMS of Ukraine», Kyiv, Ponomarenko O.P. ,   Center for neonatal surgery for malformations and their rehabilitation of SI «Institute of Pediatrics, Obstetrics and Gynecology named after academician O.M. Lukyanova of the NAMS of Ukraine», Kyiv
Published: December 2024

Aim - to determine the tactics of diagnosis and surgical correction of megaduodenum and its complications in children operated on in the neonatal period for duodenal atresia.
Materials and methods. A retrospective analysis of the medical records of 5 patients with megaduodenum who were treated at the SI «Institute of Pediatrics, Obstetrics and Gynecology named after academician O.M. Lukyanova of the NAMS of Ukraine» was performed for the period from 2018 to 2023. In the neonatal period, these children were operated on for duodenal atresia at their place of residence (n=3) or at the Institute (n=2).
Results. The diagnosis of megaduodenum was confirmed in 100% of cases. All patients underwent surgery. Stapled longitudinal constrictive duodenoplasty was performed. Intraoperatively, the anatomy of the megaduodenum was examined in detail: its diameter ranged from 42 mm to 90 mm, on average 63.4±21.16 mm, length from 50 mm to 140 mm, on average 98±37.01 mm. In all cases, the patency of the previous duodeno-duodenal anastomosis was monitored. Its diameter ranged from 18 mm to 30 mm. The effect of the surgical treatment in all patients was good.
Conclusions. The developed diagnostic algorithm includes: radiography of the abdominal cavity, X-ray contrast study of the gastrointestinal tract, ultrasound of the ENT organs, EGD, and others if necessary.
Surgical correction of megaduodenum and its complications consists of stapled longitudinal narrowing duodenoplasty, which, in combination with conservative treatment methods, leads to good functional results.
The research was carried out in accordance with the principles of the Declaration of Helsinki. The research protocol was approved by the Local Ethics Committee of all institutions mentioned in the work. Informed consent of the women was obtained for the research.
The authors declare no conflict of interest.
Limited contact multiplane osteosynthesis of shinbone fractures
Authors:   Shupyk National Healthcare University of Ukraine, Kyiv, Bilinsky P.I. , But V.P. ,   Shupyk National Healthcare University of Ukraine, Kyiv, Marthuk T.E. ,   Shupyk National Healthcare University of Ukraine, Kyiv
Published: December 2024

Aim - to improve the results of treatment of shinbone fractures with limited contact multiplane osteosynthesis device, to investigate its fixation capabilities.
Materials and methods. On the base of systemic approach, conceptual substantiation, theoretic methods of mathematic and computer modeling a new method of limited contact multiplane osteosynthesis of diaphyseal shinbone fractures (SBF) and device for its realization were developed. Comparative analysis of fixing capabilities of the developed device and full-contact plate was performed by means of finite element method. Stress-strain state of the “fixative-bone” system of different fixation methods of SBF was investigated.
Results. Theoretic data about the size of the micromobility of bone fragments depending on the fracture line pattern, imposed force, specific features of the fixative construction were obtained. Stressed state of plates, its dependence from fixative construction, fracture pattern, load size was studied. Influence of reposition stabilization of fragments by screws in oblique and comminuted fractures on fixation rigidity, micromotion of fragments, stress of fixative construction elements and bone fragments was investigated.
Fragment fusion was noted in all 380 patients with SBF operated on with a limited contact osteosynthesis device.
Conclusions. The developed device for limited contact multiplane osteosynthesis of shinbone fractures and the method of its application simplifies surgical intervention, minimises trauma to the fragments, and ensures their stable fixation and optimal conditions for fusion.
No conflict of interest was declared by the authors.
Green School and Its Implementation in Islamic Educational Institutions in Indonesia
Authors: Mahyani Aang , Ruswandi Agus
Published: December 2024

Climate change regarding global warming threatens human life on earth, so there needs to be solutions from various parties to reduce the negative effects of climate change. Implementing these principles in Islamic educational institutions in Indonesia still needs to improve understanding, policies, and implementation in the field. Therefore, this study aims to analyse the implementation of Green Schools in Islamic educational institutions in Indonesia, identifying factors that support and hinder its implementation. The research method used is a case study with a qualitative approach—data collection techniques using document analysis from research results published in national and international journals. Data analysis is done through data condensation, data display, and verification. The green school program is a program that must be implemented in educational institutions. Green schools and green buildings can improve teacher performance and academic achievement. Various Islamic educational institutions have carried out green school programs; some have received Adiwiyata awards from the Indonesian Government. However, Islamic education institutions still need to implement green schools properly. Islamic educational institutions should consistently implement green school programs in their respective institutions to reduce climate change's negative effects.

Perubahan iklim dan pemanasan global mengancam kehidupan manusia, sehingga diperlukan solusi dari berbagai pihak untuk mengurangi dampak negatifnya. Salah satu solusi adalah program green school di lembaga pendidikan, termasuk di lembaga pendidikan Islam di Indonesia. Namun, implementasi program ini masih menghadapi tantangan, terutama terkait pemahaman, kebijakan, dan pelaksanaan di lapangan. Penelitian ini bertujuan untuk menganalisis implementasi green school di lembaga pendidikan Islam, serta mengidentifikasi faktor pendukung dan penghambatnya. Metode yang digunakan adalah studi kasus kualitatif dengan teknik analisis dokumen dari jurnal nasional dan internasional. Program green school memiliki manfaat, seperti meningkatkan kinerja guru dan prestasi akademik siswa. Walau beberapa lembaga telah meraih penghargaan Adiwiyata, konsistensi penerapan di lembaga pendidikan Islam perlu ditingkatkan untuk mengurangi dampak perubahan iklim.
Digital Al-Quran: A Medium to Assist Students in Practicing Religious Rituals
Authors: Maulana Luthfi , Ardiyansyah Sendi Maramis , Pratama Jaka Putra , Romli Usup
Published: December 2024

This research aims to explore the potential for using digital Al-Quran in enriching the religious practices of students at the Faculty of Technical and Vocational Education, Indonesian Education University (FPTK UPI). This research adopts a survey research design with a quantitative approach. Data was collected through a questionnaire given to FPTK UPI students, with a focus on the use of the Digital Al-Quran and its impact on their religious practices. Statistical analysis is used to analyze data to gain a deeper understanding. The research results show that the digital Koran positively influences religious practice by providing easy access to religious teachings, increasing understanding, and showing good levels of engagement, confirming its role as a potential tool in enriching students' religious experiences. Thus, the digital Al-Quran is recognized as having great potential to increase religious understanding and religious involvement in higher education environments in Indonesia, especially at FPTK UPI.

Penelitian ini bertujuan untuk mengeksplorasi potensi penggunaan Al-Qur’an digital dalam memperkaya praktik keagamaan mahasiswa di Fakultas Pendidikan Teknik dan Kejuruan Universitas Pendidikan Indonesia (FPTK UPI). Penelitian ini mengadopsi desain penelitian survei dengan pendekatan kuantitatif. Data dikumpulkan melalui kuesioner yang diberikan kepada mahasiswa FPTK UPI, dengan fokus pada penggunaan Al-Qur’an Digital dan dampaknya terhadap praktik keagamaan mereka. Analisis statistik digunakan untuk menganalisis data guna mendapatkan pemahaman yang lebih mendalam. Hasil penelitian menunjukkan bahwa Al-Qur’an digital secara positif memengaruhi praktik keagamaan dengan memberikan kemudahan akses terhadap ajaran agama, meningkatkan pemahaman, dan menunjukkan tingkat keterlibatan yang baik, mengkonfirmasi perannya sebagai alat yang berpotensi dalam memperkaya pengalaman keagamaan mahasiswa. Dengan demikian, Al-Qur’an digital diakui memiliki potensi besar untuk meningkatkan pemahaman agama dan keterlibatan keagamaan di lingkungan pendidikan tinggi di Indonesia, khususnya di FPTK UPI.
Improving Student Learning Outcomes Using the Mind Mapping Method
Authors: Mutaqin Asep Sofyan , Nurhamzah
Published: December 2024

A preliminary study at SDN 224 Cijambe found two key issues: students' limited understanding of Islamic Religious Education and low learning outcomes on Asmaul Husna in grade V. This study aims to: 1) examine the learning process with Mind Mapping, 2) assess learning outcomes after using this method, and 3) determine if Mind Mapping can improve student performance in PAI on Asmaul Husna material. The research, a classroom action study (PTK), used Elliot's Spiral model across two cycles, each involving planning, action, observation, and reflection stages. Conducted in grade V with 28 students, data collection utilized observation, tests, and documentation. Results showed that only 5 students (17.86%) met objectives in the pre-cycle, increasing to 8 students (28.57%) in the first cycle and reaching 20 students (71.43%) in the second cycle. Thus, Mind Mapping was found to significantly enhance learning outcomes, supporting student comprehension and engagement in PAI at SDN 224 Cijambe, Bandung.
Leonard C. Sebastian and Syed Huzaifah Bin Othman Alkaff, Indonesia and Islam in Transition
Authors: Asmara Edo Kusuma
Published: December 2024

Leonard C. Sebastian and Syed Huzaifah Bin Othman Alkaff, Indonesia and Islam in Transition. Singapore: Palgrave Macmillan, 2024, pp. xxxv + 274, €96.29 (ebook), €119.99 (hb), ISBN 978-981- 97-1140-6 (ebook), ISBN 978-981-97-1139-0 (hbk).
COVID-19 and Collegiate Athletics
Authors: Robert D. McDermand  , Stephen M. Kosovich
Published: December 2024

The COVID-19 pandemic had a substantial impact on American institutions of higher education. The suspension of in-person learning, closed dormitories, and canceled events led to widespread worries about the impact of the pandemic on institutional finances. Concerns subsequently spread to include apprehensions regarding how the pandemic would affect college athletics budgets. Using data from the Knight-Newhouse College Athletics Database, this paper analyzes the financial impact of COVID-19 on the revenues and costs of Division I athletics departments. The results show that revenues fell across most athletic departments, with the greatest declines occurring in those institutions with the highest revenues prior to the pandemic. Although costs also fell during the pandemic for most institutions, these reductions did not fully cover losses in revenue for all institutions and, therefore, required some universities to increase subsidies from other institutional sources or student fees.
Outpatient follow-up of patients with atrial fibrillation and flutter by a primary care physician. Guidelines
Authors: Drapkina O. M. , Boytsov S. A. , Golukhova E. Z. , Davtyan K. V. , Drozdova L. Yu. , Ipatov P. V. , Kalinina A. M. , Martsevich S. Yu. , Savchenko E. D. , Kharlap M. S. , Shepel R. N. , Yavelov I. S. , Zhamalov L. M.
Published: December 2024

The guidelines contain a description of providing outpatient follow-up of patients with atrial fibrillation and flutter by a general practitioner, the approximate volume and frequency of paraclinical studies, information on the diagnosis and treatment of the disease, and the prevention of complications.

The guidelines are intended for district primary care physicians, general practitioners (family doctors), as well as for the nursing staff, for paramedics of the rural health posts if they are assigned the attending physician functions. The guidelines can be used by health professionals, heads of primary healthcare facilities and their divisions.
Collaboration in the Rhetoric of Science, Technology, and Medicine
Authors: Johnson Nathan R.
Published: December 2024

The concept of collaboration lies at the heart of this special issue of Poroi. This issue is rooted in the papers and discussions that emerged from the co-sponsored 2023 preconference of the Association for the Rhetoric of Science, Technology, and Medicine (ARSTM) and the National Communication Association's Environmental Communication Division (NCA-ECD). The collection brings together scholarship that examines, theorizes, and enacts collaboration from a variety of perspectives. The preconference served as an important space where scholars and practitioners from rhetoric, environmental communication, science and technology studies, and related fields engaged with the pressing challenges and opportunities of working together across disciplinary and institutional boundaries. 
Spanyol szarvasmarhák bemutatása, különös tekintettel az őshonos fajtákra, valamint kutatásuk eredményeire
Authors: Tőzsér János , Vertséné Zándoki Rita , Kosztolányiné Szentléleki Andrea
Published: December 2024

A tanulmány 12 spanyol őshonos, illetve megőrzésre váró szarvasmarha jellemzőit mutatja be. A szerzők ismertetik az egyes fajták származását, elterjedését, színét, súlyát és magasságát. Leírják a fajták FAO szerinti besorolását, valamint rávilágítanak a vizsgált fajták napjainkban történő hasznosítására is. A tanulmány második részében, a megvédendő spanyol szarvasmarhafajtákkal foglalkozó kutatómunkák eredményeit összegzik, a genetikai, a takarmányozási, a hústermelési és a húsminőségi témakörben.
Инстинкт мастерства и структура промышленного искусства
Authors: Веблен Торстейн
Published: December 2024

Книга известного американского экономиста и социолога Торстейна Веблена «Инстинкт мастерства и структура промышленного искусства», впервые опубликованная в 1914 году, представляет собой глубокий анализ эволюции человеческого труда и производственных отношений. Основой работы является идея «инстинкта мастерства» — врожденного стремления человека к эффективному и целесообразному труду, который, по мнению автора, выступает фундаментальным двигателем социального и технического прогресса. Веблен прослеживает развитие этого инстинкта от примитивных обществ до индустриальной эпохи, анализируя его взаимодействие с социальными институтами и культурными нормами. Он критически рассматривает современную экономическую систему, которая подавляет этот инстинкт, отдавая предпочтение стандартизации и массовому производству, и предлагает альтернативный взгляд на организацию производства и распределение благ.
"Инстинкт мастерства и структура промышленного искусства" бросает вызов господствующим экономическим теориям своего времени и остается влиятельным трудом, актуальным для критики потребительского общества и обсуждений о будущем труда и технологий. Книга представляет особый интерес для социологов, экономистов, антропологов и историков.
Protocol for Multiplexed Immunofluorescence Imaging and Analysis of the Tumor Microenvironment v1
Authors: S Lisse Thomas
Published: December 2024

High throughput multiplex immunofluorescent (mIF) image preparation and analysis provides arapid, dependable, and informative method for clinical diagnosis and prognosisof diseases and therapeutic responses. This protocol describes the preparationof a melanoma mIF panel designed to detect six protein biomarkers along withDAPI in formalin-fixed paraffin-embedded (FFPE) human melanoma tumor sections. Themethod involves sequential staining of tissue sections using the Leica BOND‱ RXautostainer through repeated cycles of heat-induced epitope retrieval (HIER),blocking, primary antibody incubation, secondary antibody binding, Opalfluorophore application, and antibody elution. The Opal fluorescent signalremains stable during the antibody stripping process, enabling additionalrounds of staining for new targets without the risk of cross-reactivity, evenfor co-localized markers. The protocol also incorporates nuclearcounterstaining with DAPI. While the protocol accommodates up to seven markers(six antigens plus DAPI), individual antigen targets can be substituted andre-optimized as needed. The outlined workflow includes the following steps: (1)Staining using the Leica Bond‱ RX, (2) Scanning with the Akoya PhenoImager HT‱2.0, and (3) image annotation and analysis using PhenoChart 3.0, inFORM‱ 3.0, andphenoptrReports 0.3.2. This protocol leverages multispectral imaging and built-in spectral unmixing tofacilitate efficient large-scale spatial signature analysis. The chosenantibodies—FoxP3, PD-L1, Sox10, PD-1, CD8, and CD68—enable a thoroughassessment of PD-L1- and PD-1-mediated immune responses in the context ofmelanoma tumor cells.
Concatenate Sequenced Data for Bioinformatics Analysis v1
Authors: Cahyani Dwi
Published: December 2024

This protocols helps to create concatenated files from a sequenced data.
Rodent ear punch assay v1
Authors: Seifert Ashley
Published: December 2024

This protocol describes the procedure used by the Seifert Lab to assay tissue regeneration following a 4mm ear punch in rodents, including Acomys spiny mice. Note that any protocol involving animals should be reviewed and approved by your Institutional Animal Care and Use Committee (IACUC) before use.
Defying “conversion therapies” of LGBTQ+ persons in Africa
Authors: Davids Hanzline
Published: December 2024

The contestation around Lesbian, Gay, Bisexual, Transgender, Queer and plus all other (LGBTQ+) persons’ genders and sexual identities is considered a colonial inheritance and modern Western imposition. Within this contested space, faith, politics, and culture play a fundamental role in inciting violence on the non-heteronormative embodiment of an LGBTQ+ person’s Sexual Orientation, Gender Identity, and Expression of Sex Characteristics (SOGIESC). One of the ways religion, culture, and politics collectively incite violence is through “conversion therapies”, which exacerbates LGBTQ+ vulnerabilities. This pseudo-therapy’s goal is to convert and suppress the SOGIESC of LGBTQ+ persons, thus leading to life-denying conditions. To counter “conversion therapies”, this article is interested in the encounter between Ruth and Boaz on the threshing floor as a site of situational vulnerability. The Hebrew Bible emphasises the depiction of threshing floors as sacred spaces. Threshing floors are traditionally used for essential life-sustaining activities such as food and sustenance. Therefore, this article seeks to queer the holy space of the threshing floor by using nego-feminism, queer agency and third space as theoretical frameworks. This article thus seeks to contribute to the knowledge production of queer agency in spaces of situational vulnerability.
Optimizing thermal management in photovoltaic panels: experimental study
Authors: Saadi Hasna , Hermanucz Péter
Published: December 2024

This study investigates the enhancement of thermal management in photovoltaic (PV) systems by
implementing a modified setup with copper pipes and an aluminium-based adhesive to boost thermal
conductivity. Conducted over a four-month period at the Hungarian University of Agriculture and Life
Sciences, the research examined the impact of varying cooling flow rates, insulation levels, and inlet
temperatures on the working temperature of a modified PV system. Findings demonstrate that full insulation
significantly raises working temperatures up to 67%, while lower inlet temperatures and increased cooling
flow rates effectively decrease them to 11,54% and 18,97% respectively. The results suggest that optimizing
thermal management can enhance PV efficiency in high-temperature environments, promoting the system's
resilience and efficiency in diverse climatic conditions.
MYTHS OF RUSSIAN PROPAGANDA IN THE INTERPRETATION OF YURY SHEVELOV
Authors:   National Technical University of Ukraine Igor Sikorsky Kyiv Polytechnic Institute, Kyiv, Ukraine, DENYSIUK Serhii
Published: December 2024

The article clarifies the role of the legacy of the remarkable scientist in disproving a number of russian propaganda myths directed against the Ukrainian language, culture, and history of Ukraine. It is important to note that Y. Shevelov, as a linguist, made a lot of efforts to deconstruct the myth of the existence of a united old-russian language, from which arose the idea of ethnic unity among three East-Slavic folks. For a long time, this concept was dominant in official imperial and later Soviet science. Contrary to the ideological notion of a united old-russian language, the researcher developed and substantiated his own scientific vision of the Ukrainian language‘s genesis, which is shared among the most modern scientists.
It is claimed that Yury Shevelov has refuted several myths about the Ukrainian language in his writings on the problems of the functioning of the modern Ukrainian language and the Soviet language policy. Y. Shevelov contrasted the propaganda assertions about the flourishing of the Ukrainian language under the USSR with serious scientific studies, in which he proved from the extensive factual material that the Soviet government in many respects outmatched its tsarist predecessors. In particular, it is talking about interference in the internal laws of the language, which was an innovation of the Soviet language policy.
It is indicated that the scientist critically assessed the move and consequences of the Ukrainization policy, which modern Russian propaganda uses as one of the proofs of the crucial role of Vladimir Lenin and the Bolshevik Party in the creation of modern Ukraine. As Y. Shevelov proved, Ukrainianization emerged as a tactical move of the ruling regime as a result of intraparty and international events and was curtailed after the final confirmation of totalitarian power in the early 1930s. It is noted that in his works, the researcher considered purely linguistic phenomena in close connection with political processes. Y. Shevelov‘s works provide a lot of valuable material for exposing one of the basic myths of modern Russian propaganda—the myth of the Great Patriotic War. The scientist points to the aggressiveness of the prewar Soviet foreign policy, aimed at expanding the area of communism, and the unheard-of militarization of all spheres of social life.
The colourful world of poetry by Anatolii Moisiienko
Authors:   Ivan Franko National University, Lviv, Ukraine, KOCHAN Iryna
Published: December 2024

Background. The colourful world of A. Moisiienko’s poetry is analyzed in the article. The author clearly outlines the linguistic picture of the writer’s world, his inner perception of the environment through the colour. The analysis is carried out in the lexical and semantic aspect, taking into account the grammatical and word-formation expression of colour designations, which allows to outline the mental consciousness of the writer, and his artistic personality, which is an integral part of the author’s poems, shapes the mood of the work, its uniqueness. The use of colours is essential in the writer’s idiostyle, which defines the creative image of the author, manifested in his views on the phenomena of nature and human life.

Methods. Descriptive, contextual, transformational-stylistic.

Results. In A. Moisiienko’s poetry, colours denote natural phenomena, serve as means of depicting landscapes, portraits, and phenomena of the surrounding world, convey the mood of the lyrical hero, and depict both abstract concepts and concrete objects. All these colourful images have absorbed the depth of national culture, folk psychology, and the individual worldview. The author’s arsenal includes both achromatic and chromatic colours. Colourful lexemes are expressed by different parts of speech: adjectives, nouns, verbs, and adverbs, which have different structures, convey different colour saturation, and are characterized by different syntagmatic patterns with different associative fields.

Conclusion. The colourful world of Anatolii Moisiienko’s poetry is his life, environment, native land, and people around him, that is, a bright, diverse national and cultural time-space in which the lyrical hero of the author’s poems lives. The colouristic paradigm of the artist’s poetic works covers the widest layer of semantic designations of objects and phenomena of the surrounding world, portrait and inner emotional characteristics. In addition to its primary meaning, the colourful word in the poetry of A. Moisiienko performs an important associative and figurative, symbolic function, becomes an individual marker of the poetic text. Each colour can vary in colour tone, saturation, and clarity, which allows one to define the surrounding world and the lyrical hero in it quite accurately and at the same time figuratively.
Structural and functional features of parceled constructions (based on the poems of Anatolii Moisiienko)
Authors:   Khmelnytskyi National University, Khmelnytskyi, Ukraine, TORCHYNSKA Nataliya , TORCHYNSKYI Mykhailo ,   Khmelnytskyi National University, Khmelnytskyi, Ukraine
Published: December 2024

Background. Parceled constructions are qualified as special stylistic figures, in which parts of a single sentence are separated into independent sentences by intonation or punctuation. The main statement is considered the basic part. The parcel is one or more defined components that function as separate syntactic units but are completely dependent on the main structure both by implication and syntactic functions.

The content-enhancing and rhythm-melodic functions of parceled constructions, which are in the first instance used to enhance their semantic weight, are considered to be the main ones.

Methods. To determine the structural and functional features of parceled constructions of Anatolii Moisiienko’s poetic works, the following methods were used: linguo-stylistic analysis (the regularities of language functioning in various spheres of communication are determined), the pragmatic method (the internal regularities of the choice and lexical units use in a typified communication situation are identified), the contextual method (the semantics of language units are analyzed in unity with their micro-context and macro-context, what makes it possible to establish the meaning of the studied element of the text), discursive analysis (characterizing of the communicative event, the situation that integrates the text, with other its components, in particular with circumstances, time, space, cognitive and psychological factors), intent analysis (actual intentions of communication participants are revealed by the features of their speech, communicative behavior).

Results. It is proposed to divide the parceled constructions into two groups: 1) parceled sentences, when the parcels are parts of complex sentences – complex ordinal, complex subjunctive, complex unconjunctive; 2) parceled parts of the sentence – subjects, predicates, adjuncts, definitions and circumstances. Parceling is determined both by the features of the rhythm-meloding of poetry and by the need to specify the peculiarities of the depicted events, first of all emphasizing their semantic weight.

Conclusions. In the poetic works of Anatolii Moisiienko, parcelation is an important stylistic tool. Parts of compound, complex sentences, parceled Predicates, and Adverbial Modifiers of manner, as well as combined constructions where different types of parceling are combined, actively play the role of parcels.
Black Bullet in the Gun: Troubling Silence and Silencing in Antiracist Teacher Education
Authors: Ohito Esther O. , Deckman Sherry L.
Published: December 2024

In this Voices: Reflective Accounts of Education essay, Esther O. Ohito considers with Sherry L. Deckman how silence and silencing are experienced corporeally in socioculturally situated spaces, foregrounding their affective contours and material effects in their exploration of emotionally charged dialogues about race and racism in educational settings. Building their narrative around a Black male teacher candidate’s experience in a social justice–oriented teacher preparation program, they reflect on the presence and effects of silence and silencing in that intimate white space. The essay concludes with implications for critical pedagogy relevant to the potentially transformative force of transgressive race talk that counteracts silence and silencing in white spaces.
A Model-based Form of Naturalised Metaphysics
Authors: Covoni Niccolò , Corti Alberto , Fano Vincenzo
Published: December 2024

The paper addresses the main meta-metaphysical question, i.e., whether it is possible to do metaphysics and, in the case of an affirmative answer, how should we do it? With such an aim in mind, we sketch the broad context in which these meta-metaphysical questions arose in the philosophical literature (§ 1); then, we present what we take to be the three most widespread conceptions of metaphysics that are available in the analytic tradition: the neo-Quinean (§ 2), metaphysics as the science of possibilities (§ 3) and metaphysics as the study of the fundamental structures of reality (§ 4). We criticise these positions throughout these paragraphs before cashing out our proposal (§ 5). Our interpretation aligns with the recently proposed approach known as ‘naturalised metaphysics’ but with crucial differences. In our view, metaphysics is not only constrained by physics; rather, it grows out from all empirical sciences. More precisely, it can be achieved using formal language and the analysis of the results of scientific theories.
O Problema da Representação na Metafísica Analítica: Analisando a Falácia Representacional no debate sobre o Tempo
Authors: Batista Ricardo Barroso
Published: December 2024

This paper critiques the contemporary reliance on linguistic analysis in metaphysics, arguing that it leads to the representational fallacy – a tendency to derive ontological conclusions from linguistic properties rather than from reality. We trace the historical roots of this issue to the Kantian and linguistic turns, which shifted metaphysical focus from ontology to semantics, situating language at the center of the philosophical inquiry. We examine how this fallacy manifests in the debate between A-theorists and B-theorists of time. Both camps rely on Structural Linguistic Representationalism – the assumption that language directly mirrors reality –, presupposing a necessary correspondence between linguistic structures and ontological facts. We argue that this dependence is misguided, as language alone cannot adequately capture the fundamental nature of reality. In addressing this issue, we analyze two approaches within the B-theory of time: the truth-conditions approach and the truthmaker approach. We contend that the truth-conditions approach reiterates the representational fallacy by deriving ontological conclusions from linguistic structures. In contrast, the truthmaker approach presents a more promising framework by shifting focus from language to ontology, grounding metaphysical explanations in the structure of reality in itself. We conclude that the pursuit of an absolute linguistic model to reveal the ultimate nature of reality is unjustified and hinders metaphysical investigation. Instead, we advocate grounding ontological inquiries in reality, using language as a tool rather than a source of metaphysical truth.
Rethinking Grounding: From Necessitation to Metaphysical Probability
Authors: Spencer Joshua
Published: December 2024

This paper challenges the conventional view that grounding relations necessitate the truth of grounded propositions, a principle often denoted as (N). The author proposes an alternative principle (P), suggesting that grounding should instead be understood in terms of “metaphysical probability.” By drawing an analogy with causation, which does not guarantee but increases the probability of an effect, the paper argues that grounding relations similarly support metaphysical probability rather than necessity. Using the framework of possible worlds, the author articulates the concept of metaphysical probability and addresses objections to its coherence and grounding. The paper concludes by emphasizing the significance of adopting (P) for a nuanced understanding of grounding.
MLOps Pipelines for GenAI in Renewable Energy: Enhancing Environmental Efficiency and Innovation
Authors: Gade Pavan Kumar
Published: December 2024

This article explores the integration of MLOps pipelines with Generative Artificial Intelligence (GenAI) in renewable energy systems, aiming to enhance environmental efficiency and foster innovation. The objectives are to evaluate advancements in energy harvesting technologies for wireless sensor networks (WSNs), analyze the potential of GenAI for optimizing renewable energy operations, and address challenges in deploying MLOps frameworks in dynamic energy environments. The principal findings reveal that MLOps pipelines enable continuous model refinement, scalability, and efficient management of GenAI models, significantly improving renewable energy applications such as resource optimization, predictive maintenance, and energy storage. Energy harvesting technologies, coupled with GenAI, promise autonomous and sustainable solutions, reducing dependency on traditional power sources. Policy implications emphasize the need for standardized regulations, investments in computational infrastructure, and ethical guidelines for AI deployment in energy systems. By addressing current challenges, policymakers and researchers can unlock GenAI's full potential, advancing global sustainability goals.
Prevalence of multidrug-resistant gram-negative bacilli (MDR-GNB) in hospital-acquired and ventilator-associated pneumonia: A comparative study from a tertiary care center, Gujarat
Authors: Pandya Himani Bhardwaj , Chauhan Amit Pravin , Patel Rachana Bhavin , Bhalodia Nidhi Mihirkumar , Lakhani Sucheta Jitendra
Published: December 2024

Antibiotic resistance poses a formidable challenge to global healthcare, with Gram-negative bacteria emerging as a primary concern. Multidrug-resistant Gram-negative bacilli (MDR-GNB) have become a significant cause of nosocomial infections, particularly pneumonia, complicate therapy, and have a detrimental impact on patients’ outcomes.

This study aims to investigate the etiology, risk factors, and antibiotic resistance patterns associated with Gram-negative bacilli (GNB) isolated from nosocomial pneumonia cases.

This prospective cross-sectional study was conducted at the Microbiology laboratory of a tertiary care Hospital in Gujarat. Patients hospitalized for >48 hours with new lung infiltrates and at least two of the following clinical features: fever, leukocytosis/leukopenia, purulent secretions, or decreased oxygenation were included. The study was initiated after the ethical approval. Patient demographic and clinical details were noted in the preformed questionnaire. A total of 64 specimens [Sputum (n= 28) and Endotracheal aspirate (ET, n=36)] were cultured on MacConkey’s agar and Blood agar and further species identification with Antimicrobial Susceptibility Pattern was done by automated Vitek-2 compact system.

Ventilator-associated Pneumonia (VAP) was found in 14.6% of infected patients, with male predominance and common in the 30-50 years age group. Out of them, 72% were mainly associated with late-onset. Overall, the major isolates were (20/64, 31%), followed by (19/64, 29.6%) and (17/64, 26.5%) both as solitary and mixed infections.76% strains of and 85% of strains were resistant to carbapenems and 93.3% of were resistant to cephalosporins and carbapenems. strains were 100% resistant to carbapenems.

The study recommends effective Infection control practices and strong antibiotic stewardship programs to reduce the morbidity and mortality of nosocomial pneumonia.
Isolation and characterization of probiotic bacteria from curd samples for evaluation of antagonistic and free radical scavenging activity as a therapeutic approach
Authors: Mali Gajanan Vishnu , Tambe Pranav Suresh , Chavan Ranjana Shirish
Published: December 2024

Probiotic microorganisms play a significant role in promoting gut health. Identifying and characterizing these organisms is very crucial for developing new paths for therapeutic research.

Screening of potential probiotic organisms from different curd samples to evaluate its antagonistic and free radical scavenging activity for therapeutic approach.

A total of 40 organisms were isolated from different curd samples using MRS agar under microaerophilic conditions. Based on Gram staining, motility, and endospore formation, 13 isolates were selected for further analysis. Catalase production was assessed in 7 non-endospore forming isolates, with 4 (LC8, 20, 27, and 30) found to be catalase negative. The probable genus of these isolates was determined using Bergey’s Manual of Systematic Bacteriology.

The isolates LC8, 20, 27, and 30, which were catalase-negative and non-endospore forming, likely belong to the genus Lactobacillus. Further screening revealed that these isolates were tolerant to a wide range of pH levels, bile tolerant, non-hemolytic, and sensitive to antibiotics. Along with these properties free radical scavenging activity, hydrophobicity testing antagonistic properties were evaluated.16S rRNA sequencing identified the isolates as belonging to and

The isolated organisms, identified as and exhibit potential antagonistic and free radical scavenging activities which makes them potent candidates for further therapeutic approach.