bluuebunny/crossref_metadata_2025 huggingface dataset:
Closure of the Bangong–Nujiang Tethyan Ocean in the central Tibet: Results from the provenance of the Duoni Formation
Authors: Zhu Zhicai , Zhai Qingguo , Hu Peiyuan , Chung Sunlin , Tang Yue , Wang Haitao , Wu Hao , Wang Wei , Huang Zhiqiang , Lee Haoyang
Published: October 2019

The closure of the Bangong–Nujiang Tethyan Ocean (BNTO) and consequent Lhasa–Qiangtang collision is vital to reasonably understanding the early tectonic history of the Tibetan Plateau before the India-Eurasia collision. The timing of the Lhasa–Qiangtang collision was mainly constrained by the ophiolite and magmatic rocks in previous studies, with only limited constraints from the sedimentary rocks within and adjacent to the Bangong–Nujiang suture zone. In the middle segment of the Bangong–Nujiang suture zone, the Duoni Formation, consisting of a fluvial delta sequence with minor andesite interlayers, was originally defined as the Late Cretaceous Jingzhushan Formation and interpreted as the products of the Lhasa–Qiangtang collision during the Late Cretaceous. Our new zircon U-Pb data from two samples of andesite interlayers demonstrate that it was deposited during the latest Early Cretaceous (ca. 113 Ma) rather than Late Cretaceous. Systemic studies on the sandstone detrital model, heavy-mineral assemblage, and clasts of conglomerate demonstrate a mixed source of both Lhasa and Qiangtang terranes and ophiolite complex. Clasts of conglomerate contain abundant angular peridotite, gabbro, basalt, chert, andesite, and granite, and minor quartzite and gneiss clasts also exist. Sandstones of the Duoni Formation are dominated by feldspathic–lithic graywacke (Qt25F14L61 and Qm13F14L73), indicative of a mixture of continental-arc and recycled-orogen source origin. Detrital minerals of chromite, clinopyroxene, epidote, and hornblende in sandstone also indicate an origin of ultramafic and mafic rocks, while garnets indicate a metamorphosed source. Paleocurrent data demonstrate bidirectional (southward and northward) source origins. Thus, we suggest that the deposition of the Duoni Formation took place in the processes of the Lhasa–Qiangtang collision during the latest Early Cretaceous (∼ 113 Ma), and the BNTO had been closed by this time.
Vitamin D receptor genetic polymorphisms are associated with oral lichen planus susceptibility in a Chinese Han population
Authors: Shen Hong , Liu Qinglan , Huang Peng , Fan Haozhi , Zang Feng , Liu Mei , Zhuo Lingyun , Wu Jingjing , Wu Guoying , Yu Rongbin , Yang Jianrong
Published: October 2019

Vitamin D receptor ( VDR ) is involved in multiple immune-mediated disorders including oral lichen planus (OLP). This study investigated the association between VDR gene polymorphisms and the risk of OLP. In total, 177 OLP patients and 207 healthy participants were recruited from the Affiliated Hospital of Stomatology, Nanjing Medical University. Eight single nucleotide polymorphisms (SNPs: rs731236, rs739837, rs757343, rs2107301, rs2239185, rs7975232, rs11574129 and rs11568820) in the VDR gene were selected and genotyped. The results showed that OLP risk was increased in subjects with the rs2239185 TT genotype (Recessive model: adjusted OR = 2.68, 95% CI = 1.28-5.62, P = 0.009) and rs7975232 CC genotype (Recessive model: adjusted OR = 2.25, 95% CI = 1.10-4.58, P = 0.026). Moreover, rs2239185 and rs7975232 ( P < 0.01) showed significant cumulative effects on OLP risk. .Haplotype analysis showed that the CC haplotype (rs2239185-rs7975232) was associated with an increased risk of OLP (OR =3.11, 95% CI = 1.42-6.83, P = 0.005), compared with the AC haplotype . In conclusion, the rs2239185 and rs7975232 variants of VDR may influence OLP susceptibility, and VDR gene polymorphisms may be candidate susceptibility regions for OLP in a Chinese Han population.
Cloning, characterization of TaGS3 gene and identification of allelic variation associated with kernel traits in wheat (Triticum aestivum L.)
Authors: Yang Jian , Zhou Yanjie , Zhang Yu'e , Hu Weiguo , Wu Qiuhong , Chen Yongxing , Wang Xicheng , Guo Guanghao , Liu Zhiyong , Cao Tingjie , Zhao Hong
Published: October 2019

Background:
Grain weight is an important yield component. Selection of advanced lines with heavy grains show high grain sink potentials and strong sink activity, which is an increasingly important objective in wheat breeding programs. Rice OsGS3 has been identified as a major quantitative trait locus for both grain weight and grain size. However, allelic variation of GS3 has not been characterized previously in hexaploid wheat.
Results :
We cloned 2445, 2393, and 2409 bp sequences of the homologs TaGS3-4A , TaGS3-7A , and TaGS3-7D in wheat ‘Changzhi 6406’, a cultivar that shows high grain weight. The TaGS3 genes each contained five exons and four introns, and encoded a deduced protein of 170, 169, and 169 amino acids, respectively. Phylogenetic analysis of plant GS3 protein sequences revealed GS3 to be a monocotyledon-specific gene and the GS3 proteins were resolved into three classes. The length of the atypical Gγ domain and the cysteine-rich region was conserved within each class and not conserved between classes. A single-nucleotide polymorphism in the fifth exon (at position 1907) of TaGS3-7A leads to an amino acid change (ALA/THR) and showed different frequencies in two pools of Chinese wheat accessions representing extremes in grain weight. Association analysis indicated that the TaGS3-7A-A allele was associated with higher grain weight in the natural population. The TaGS3-7A-A allele was favoured in global modern wheat cultivars but the allelic frequency varied among different wheat-production regions of China, which indicated that this allele is of potential utility to improve wheat grain weight in certain wheat-production areas of China.
Conclusions :
The novel molecular information on wheat GS3 homologs and the KASP functional marker designed in this study may be useful in marker-assisted breeding for genetic improvement of wheat.
AMAFRICA, a patient-navigator program for accompanying lymphoma patients during chemotherapy in Ivory Coast: a prospective randomized study
Authors: KOFFI Kouassi Gustave , Silué DA , Laurent C , Boidy K , Koui S , Compaci G , Adeba ZH , Kamara I , Botty RP , Bognini A.S , Sanogo I , Despas F , Laurent G
Published: October 2019

Background Previous studies have indicated that accompanying socially undeserved cancer patients through Patient Navigator (PN) or PN-derived procedures improves therapy management and reassurance. At the Cancer Institute of Toulouse-Oncopole (France), we have implemented AMA (Ambulatory Medical Assistance), a PN-based procedure adapted for malignant lymphoma (ML) patients under therapy. We found that AMA improve adherence to chemotherapy and safety. In low-middle income countries (LMIC), refusal and abandonment were documented as major adverse factors for cancer therapy. We reasoned that AMA could improve clinical management of ML patients in LMIC. Methods This study was set up in the Abidjan University Medical Center (Ivory Coast) in collaboration with Toulouse. Hundred African patients were randomly assigned to either AMA or control group. Main criteria of judgment were refusal and abandonment of CHOP or ABVD chemotherapy. Results We found that AMA was feasible and has significant impact on refusal and abandonment. However, only one third of patients completed their therapy in both groups. No differences were noted in terms of complete response rate (CRR) (16% based on intent-to-treat) and median overall survival (OS) (6 months). The main reason for refusal and abandonment was limitation of financial resources. Conclusion Altogether, this study showed that PN may reduce refusal and abandonment of treatment. However, due to insufficient health care coverage, its ultimate impact on OS remains limited.
Prevalence and Antifungal Susceptibility of Candida albicans Causing Vaginal discharge Among Pregnant Women in Lebanon
Authors: Ghaddar Nahed , Anastasiadis Elie , Halimeh Rawad , Ghaddar Ali , Dhar Rita , AlFouzan Wadha , Yusef Hoda , Chaar Mira El
Published: October 2019

Background: Vaginal candidiasis is frequently prevalent in pregnant women and is associated with sepsis and adverse neonatal outcomes. This study determined the presence of Candida species in symptomatic pregnant women and evaluated the antifungal susceptibility profile of the isolated strains. It also aimed to explore whether Candida species predicts gestational complications and adverse neonatal outcomes. Methods: A total of 258 pregnant women at 35 to 37 week of gestation participated in this study. Vaginal swabs from these patients were collected at various obstetrics and gynecology clinics in Lebanon for a period of 12 months. Candida isolates were identified at species level and antifungal susceptibility of Candida albicans to fluconazole (FCZ), amphotericin B (AMB), itraconazole (ICZ) and voriconazole (VCZ) was determined by the agar-based E-test method. Results: Among 258 women tested, 100 (39%) were positive for Candida species. C. albicans, C. glabrata and C. krusei were isolated from 42%, 41% and 17% of the women, respectively. C. albicans had significant positive associations with gestational diabetes while C. kreusi or C. glabrata had significant positive associations with gestational complications and vaginal discharge. The antifungal susceptibility tests of C. albicans isolates revealed 97.5%, 90%, 87.5% and 97.5% susceptibility to AMB, FCZ, ICZ and VCZ, respectively. . Conclusion: The current study revealed high incidence of both C. albicans and non-C. albicans strains causing vulvovaginitis among pregnant women in Beirut, Lebanon. Whereas the susceptibility rates of C. albicans against AMB and VCZ were high, FCZ and ICZ proved comparatively less efficacious. The resistance profile of circulating C. albicans among pregnant women can predict the best outcome of appropriate prophylaxis or treatment of neonatal candidiasis. Vaginal candida colonization might lead to adverse neonatal outcome or gestational complications thus Candida screening as antennal follow up is advised.
Treatment of Chronic Active Antibody-mediated Rejection in Renal Transplant Recipients – A single center retrospective study
Authors: Author) Hsien-Fu Chiu(Former Corresponding , Wen Mei-Chin , Wu Ming-Ju , Chen Cheng-Hsu , Yu Tung-Min , Chuang Ya-Wen , Huang Shih-Ting , Tsai Shang-Feng , Lo Ying-Chih , Ho Hao-Chung , Author) Kuo-Hsiung Shu(New Corresponding
Published: October 2019

Background: A plethora of evidences suggest that the most important cause of late graft loss in renal transplant recipients is chronic active antibody-mediated rejection. However, there are no consensus on treatment strategies.
Methods: We retrospectively analyzed clinical and pathological data of renal transplant recipients who received kidney graft biopsy with confirmed diagnosis of chronic active antibody-mediated rejection in the past 7 years. The patients were divided into two groups according to treatment strategy: Group 1: aggressive treatment (double filtration plasmapheresis and one of the followings: rituximab, intravenous immunoglobulin, antithymogycte globulin, bortezomib, or methylprednisolone pulse therapy); and group 2: supportive treatment.
Results: From February 2009 to December 2017, a total of 82 patients with biopsy-proven chronic antibody mediated rejection were identified. Kaplan-Meier analysis of death-censored graft survival showed a worse survival in group 2 (P = 0.015 by log-rank test). Adverse event-free survival was lower in group 1, whereas patient survival was no significant different. Proteinuria and supportive treatment were independent risk factors for graft loss in multivariate analysis.
Conclusions: Aggressive treatment was associated with better graft outcome. However, higher incidence of adverse events merit personalized treatment, especially for those with higher risk of infection. Appropriate prophylactic antibiotics are recommended for aggressive treatment patients.
Key words: chronic active antibody mediated rejection, kidney transplantation, graft survival, adverse events
An improved catalogue of putative synaptic genes defined exclusively by temporal transcription profiles through an ensemble machine learning approach
Authors: Obregón Flavio Pazos , Palazzo Martín , Soto Pablo , Guerberoff Gustavo , Yankilevich Patricio , Cantera Rafael
Published: October 2019

Background . Assembly and function of neuronal synapses require the coordinated expression of a yet undetermined set of genes. Previously, we had trained an ensemble machine learning model to assign a probability of having synaptic function to every protein-coding gene in Drosophila melanogaster. This approach resulted in the publication of a catalogue of 893 genes which we postulated to be very enriched in genes with a still undocumented synaptic function. Since then, the scientific community has experimentally identified 79 new synaptic genes. Here we use these new empirical data to evaluate our original prediction. We also implement a series of changes to the training scheme of our model and using the new data we demonstrate that this improves its predictive power. Finally, we added the new synaptic genes to the training set and trained a new model, obtaining a new, enhanced catalogue of putative synaptic genes.

Results . The retrospective analysis demonstrate that our original catalogue was significantly enriched in new synaptic genes. When the changes to the training scheme were implemented using the original training set we obtained even higher enrichment. Finally, applying the new training scheme with a training set including the 79 new synaptic genes, resulted in an enhanced catalogue of putative synaptic genes. Here we present this new catalogue and announce that a regularly updated version will be available online at: http://synapticgenes.bnd.edu.uy

Conclusions . We show that training an ensemble of machine learning classifiers solely with the whole-body temporal transcription profiles of known synaptic genes resulted in a catalogue with a significant enrichment in undiscovered synaptic genes. Using new empirical data provided by the scientific community, we validated our original approach, improved our model an obtained an arguably more precise prediction. This approach reduces the number of genes to be tested through hypothesis-driven experimentation and will facilitate our understanding of neuronal function.

Availability : http://synapticgenes.bnd.edu.uy
Risk factors and racial disparities related to low maternal birth satisfaction with labor induction: a prospective, cohort study
Authors: Hamm Rebecca F , Srini Sindhu K , Levine Lisa D
Published: October 2019

Background: Decreased birth satisfaction has been associated with labor induction. Yet, there is a paucity of data evaluating risk factors for decreased satisfaction associated with labor induction. We aimed to determine what factors impact low birth satisfaction in labor induction and evaluate racial disparities in birth satisfaction.

Methods: We performed a prospective cohort study of women with term, singleton gestations undergoing labor induction at our institution from Jan 2018 to Jun 2018. Women completed the validated Birth Satisfaction Scale-Revised postpartum, which is subdivided into 3 domains: (1) quality of care provision, (2) women's personal attributes, and (3) stress experienced during labor. A total satisfaction score above the mean was classified as “satisfied”, and below as “unsatisfied.” Domain and item scores were compared by race.

Results: 330 of 414 (79.7%) eligible women were included. There was no significant difference in birth satisfaction by age, body mass index, Bishop score, or labor induction agent. Black women were more 75% likely to be unsatisfied than non-Black women (54.0% vs. 37.2%, OR 1.75 [95%CI 1.11-2.76], p=0.037), nulliparas were more 71% likely to be unsatisfied than multiparas (54.2% vs. 40.9%, OR 1.71 [95%CI 1.09-2.67], p=0.019), and women whose labor resulted in cesarean birth were more almost 3 times more likely to be unsatisfied than women with a vaginal birth (67.4% vs. 42.3%, OR 2.82 [95%CI 1.69-4.70], p<0.001). Additionally, increased labor length quartile was associated with decreased satisfaction (p=0.003). By race, domain 3 scores, which reflect preparedness for labor, were lower for Black women. No differences were seen for domain 1 or 2.

Conclusions: Black race, cesarean birth, and increasing labor length were identified as risk factors for low birth satisfaction among women who underwent labor induction. Further studies should explore interventions to target women at risk for low birth satisfaction.
Individual and healthcare system factors influencing antenatal care attendance in Saudi Arabia
Authors: Alanazy Wdad , Brown Amy
Published: October 2019

Background The World Health Organisation recommends women have at least 4 antenatal care visits (ANC) during a low risk pregnancy. However, in Saudi Arabia, many mothers miss these appointments placing their health and that of their baby at risk. Limited research exploring why this is happening usually focuses on low maternal education or personal barriers such as lack of transport. The aim of the current research was therefore to understand what factors at the individual and healthcare systems level were associated with missing antenatal care in Saudi Arabia.Methods Two hundred and forty two pregnant women in their third trimester completed a questionnaire examining their care attendance alongside barriers to attending care. These included maternal demographic background, health literacy, personal barriers, health care system factors and staff communication).Results Over half of women had missed at least one appointment and a third had delayed their care. Mothers who had missed appointments blamed health care system factors such as poor clinic facilities and waiting times. Attending care was not associated with maternal education or literacy. However perceptions of staff communication, consistency and care were lower amongst those who had missed at least one appointment.Conclusions Although in previous research health professionals believe it is maternal education that leads to poor attendance, in our sample at least, it is in fact perceptions of staff communication that affect attendance. Making changes at the health care level e.g. through adapting clinic times and investing in staff training may increase antenatal care attendance in Saudi Arabia.
Measurement and calibration of the nucleus position and its cross-sectional area ratio to increase the accuracy of finite element analysis
Authors: Li Jingchi , Xi Zhipeng , Zhang Xiaoyu , Sun Shenglu , Xie Lin , Liu Yang
Published: October 2019

Background: As a widely used biomechanical research method, finite element analysis (FEA) is a significant tool for investigating the pathogenesis of disc degenerative diseases and optimizing of spine surgical methods. However, the definitions of the relative nucleus position and its cross-sectional area ratio do not conform to a uniform standard, thus affecting the accuracy (ACC) of the FEA. Hence, this study aimed to determine a precise definition of the relative nucleus position and its cross-sectional area ratio to increase ACC of following FEA studies. Methods: The lumbar relative nucleus position and its cross-sectional area ratio were measured from magnetic resonance imaging data, and then calibrated and validated via FEA. Imaging data from patients without disc degeneration were recruited. The L4-L5 nucleus and disc cross-sectional areas and the distances between the edges of the annulus and nucleus were measured; the ratios between these values were calculated as P1 and P2, respectively. The FEA model was constructed using these measured values, and the relative nucleus position was calibrated by estimating the differences in the range of motions (ROMs) between the model, wherein the ligaments, facet joints and nucleus were supressed, and an in vitro study. Then, ACC were re-estimated in the model with all non-bony structures to validate the measured and calibrated indicators. Results: The interobserver homogeneity is acceptable, and the measured P1 and P2 values are 1.22 and 38%, respectively. Furthermore, an ACC of up to 99% was attained for the model under flexion–extension conditions when the calibrated P1 value (1.62) was used, with a model validation of greater than 90% attained under all loading conditions. Conclusion: The measured and calibrated relative nucleus position and its cross-sectional area ratio increase the ACC of the FEA model, and can therefore be used in subsequent studies.
In Vitro Biomechanical Testing of Equine Metacarpophalangeal Collateral Ligaments and Collateral Ligaments Repair Using Suture Anchors.
Authors: Grzeskowiak Remigiusz Maciej , Rifkin Rebecca E. , Mulon Pierre Yves , Harper David P. , Adair H. Steve , Anderson David E.
Published: October 2019

Background The disruption of equine metacarpophalangeal (MCPCL) and metatarsophalangeal collateral ligament (MTPCL) occurs as a result of traumatic events and it has been associated with guarded to poor prognosis for the return to athletic performance before the injury. Rupture of the MCPCL induces joint laxity which can, directly and indirectly, lead to a cartilage damage of the metacarpophalangeal joint (MCPJ). The literature describes several methods of the surgical management of those injuries, including the suture anchors. However, the knowledge about their biomechanical performance in the equine MCPCL repair model is lacking. This study describes the method of suture anchor placement within the metacarpal bone as well as reveals data of the biomechanical testing. The first objective was to perform bending tests on equine metacarpophalangeal joints with intact metacarpophalangeal collateral ligaments. The second objective was to perform similar tests on the metacarpophalangeal joints, having completely severed metacarpophalangeal collateral ligaments which were reattached to the suture anchors.Results The results of the biomechanical testing showed that the suture anchor repairs obtained 15% of the intact metacarpophalangeal collateral ligaments’ maximum load, 34% of their bending stiffness, 14% of their load at maximum flexure extension, and 82% of the maximal flexure extension. The suture anchor placement within the bone can be performed quick and in the feasible way. The results of the biomechanical testing did not vary significantly between the tested types of the suture anchors used in this study.Conclusions The repairs with the suture anchors achieved lower biomechanical testing results compared with the intact metacarpophalangeal collateral ligaments; however, the anatomical position of the joint could be easily restored with the repair. The use of anchors may anatomically restore the ligament and provide additional mechanical support for the injured metacarpophalangeal collateral ligaments.
Prognostic value of platelet count in lung cancer: a systematic review and meta-analysis
Authors: Yuan Yuan , Zhong Hai , Ye Liang , Li Qian , Fang Rong Su , Gu Wei , Qian Ying Ying
Published: October 2019

Background : The prognostic value of pretreatment elevated platelet count remains controversial in lung cancer patients. We performed the present meta-analysis to determine the precise role of it in these patients.Methods: We performed a multiple search strategy in PubMed database, EMBASE and Cochrane Library to identify eligible studies. Disease-free survival (DFS) /Progress-free survival (PFS)/Time to progress(TTP) and Overall survival (OS) were used as outcomes with hazard ratio (HR) and its 95% confidence intervals (CIs). Heterogeneity among studies and publication bias were also evaluated.Results : A total of 39 studies including 16696 lung cancer patients were eligible in the analysis. Overall, the pooled analysis showed that pretreatment elevated platelet count was associated with poorer OS (HR= 1.47, 95%CI: 1.31-1.66, P<0.001) and poorer DFS/PFS/TTP ((HR=1.63, 95%CI: 1.28-2.09, P<0.001) in patients with lung cancer compared with normal platelet count. In subgroup analyses, pretreatment elevated platelet count was also associated with poorer OS and DFS/PFS/TTP in most subgroups. There was no evidence of publication bias.Conclusions : This meta-analysis revealed that pretreatment elevated platelet count was an independent predictor of OS and DFS/PFS/TTP in lung cancer patients. Large scale prospective studies and a validation study are warranted.
Spatio-temporal distribution and determinants of home delivery in Ethiopia. Multilevel and spatial analysis of EDHS 2005- 2016
Authors: Tadesse Zemenu Tessema , Tiruneh Sofonyas Abebaw
Published: October 2019

Background: Globally, only 80% of live births occurred at health facilities assisted by skilled health personnel. In Ethiopia, only 26% of live births attended by skilled health personal. The aim of this study was to assess the spatial patterns and determinants of home delivery in Ethiopia from 2005 to 2016. Method: A total of 34,348 women who gave live birth in the five years preceding each survey were included for this study. ArcGIS version 10.7 software was used to visualize spatial distribution for home delivery. The Bernoulli model was applied using Kilduff SaTScan version 9.6 software to identify significant purely spatial clusters for home delivery in Ethiopia. Result: Home delivery was declined from 94.78% in 2005 to 90.05% in 2011, and 73.44% in 2016 in Ethiopia. Among the three surveys, consistently high clustering of home delivery was observed in Amhara and Southern Nation Nationalities and People Regions of Ethiopia. In spatial scan statistics analysis, a total of 128 clusters (RR= 1.04, P-value < 0.001) in 2005, and 90 clusters (RR = 1.11, P-value < 0.001) in 2011, and 55 clusters (RR = 1.29, P-value < 0.001) in 2016 significant primary clusters were identified. Educational status of women and husband, religion, distance to the health facility, mobile access, antenatal care visit, birth order, parity, wealth index, residence, and region were statistically associated with home delivery. Conclusion: The spatial distribution of home delivery among the three consecutive surveys were non-random in Ethiopia. Low educational status of women and her husband, long distance to the health facility, poor wealth index, rural residence, multiparity, have no mobile access, living in Amhara and SNNP region, and had no antenatal care visit were significant predictors of home delivery in Ethiopia. Therefore, An intervention needs to improve the coverage of antenatal care, women and her husband's education, health care facilities and mobile access. Special attention should give women live in Amhara and SNNPR regions. Key Words: Home delivery, EDHS, Spatial Distribution, Ethiopia.
Mitochondrial DNA copy number in cervical exfoliated cells and risk of cervical cancer among HPV-positive women
Authors: Sun Wei , Qin Xueyun , Zhou Jing , Xu Mingjing , Lyu Zhangyan , Li Xin , Zhang Kai , Dai Min , Li Ni , Hang Dong
Published: October 2019

Background: Although human papillomavirus (HPV) infection has been recognized as the major cause of cervical cancer, only a minority of HPV-infected women develop this malignancy. An increasing amount of evidence suggests that alterations of mitochondrial DNA copy number (mtCN) may contribute to carcinogenesis. However, the relationship between mtCN and cervical cancer remains unknown. Methods: In this case-control study, we included 591 cervical cancer cases and 373 cancer-free controls, all of whom were infected with high-risk HPV. Relative mtCN in cervical cancer exfoliated cells was measured by qRT-PCR assays, and logistic regression analysis was performed to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Results: HPV16, 18, 52, and 58 were the most common types in both case and control groups. Median mtCN in cases was significantly higher than that in controls ( P = 0.03). After adjustment for age and HPV types, the highest quartile of mtCN was associated with increased odds of having cervical cancer (OR = 1.77, 95% CI = 1.19, 2.62; P < 0.01), as compared to the lowest quartile. A dose-response effect of mtCN on cervical cancer was also observed ( P trend < 0.001). The interaction between mtCN and HPV types was statistically nonsignificant. Conclusions: Increased mtCN in cervical exfoliated cells is associated with cervical cancer after HPV infection. Our study provides a basis for future studies to determine the potential of mtCN as a novel biomarker in cervical cancer screening.
Effects of co-composted cow manure and poultry litter on the extractability and bioavailability of trace metals from the contaminated soil irrigated with wastewater
Authors: Haroon Bushra , Hassan Amjad , Abbasi Arshad Mehmood , Ping An , Yang Shao , Irshad Muhammad
Published: October 2019

It is generally recognized that agricultural soils accumulate toxic metals after long-term wastewater irrigation. The removal of trace metals (TMs) from the soil is not possible. Therefore, this study investigated the effects of the addition of manure on the extractability and bioavailability of TM from the contaminated soil after wastewater irrigation. Soils samples were treated with co-composted cow manure (CM) and poultry litter (PL) at 10 and 20 t ha−1. The study showed that addition of manure enhanced fenugreek biomass and reduced TM uptake depending on the combination of composted manures used. TM concentrations in the fenugreek shoots varied in the order of Pb > Ni > Zn > Cu > Cd. A higher amount of manure mixture especially composted with the privet and cypress residues decreased the extractability of TM from the contaminated soil. Soils amended with PL reduced TM concentrations more than CM; this is also true for the plant uptake. The variation of TM in plants was positively associated with their concentrations in the soil and adversely related to the plant biomass. This study confirmed that the combined use of composted manure with plant residues can be an effective addition for ameliorating the TM pollution in soils and crops.
Conjuntos históricos rurales del área metropolitana de Mérida, Yucatán. Rururbanización entre siglos XX-XXI
Authors: Paredes-Guerrero Blanca , Pat-Canul Julio César
Published: October 2019

El concepto rururbanización se refiere al proceso de transformación espacial de asentamientos cuyo origen rural se trastoca debido al crecimiento urbano, el cual, en su irrefrenable expansión, ocupa aquellos ámbitos configurando un híbrido entre lo rural y lo urbano. Este trabajo aborda el estudio de once poblaciones históricas —antiguas haciendas y pueblos— ubicadas en los bordes de la ciudad de Mérida, Yucatán, en México, para explicar el proceso de rururbanización acelerado en la última década de la región. Los resultados señalan que este proceso tiene como condición previa las políticas en materia de uso de suelo que el gobierno federal y los estatales implementaron décadas atrás para ese fin y que básicamente consistieron en el cambio del régimen ejidal al privado de suelos, los decretos de expropiación y la acción metropolizadora a priori del sector gubernamental en ciudades medias del país. La investigación también concluye y demuestra los efectos que dichas acciones del gobierno tienen sobre el territorio en materia de uso de suelo y forma de ocupación del espacio, y los cambios en el tipo de habitantes y de sus edificaciones, cuyo resultado general se observa en la actual fisonomía rururbana de esos asentamientos.
Los estudios de impacto socioambiental en Colombia: ¿Una forma de salvaguarda a la autodeterminación y subsistencia de los pueblos indígenas?
Authors: Ramírez-Monroy Hirán David , Piraquive-Aldana Margarita Rosa
Published: October 2019

En el presente artículo se desarrollará el problema jurídico planteado, que busca determinar si la regulación de los estudios de impacto socioambiental en Colombia otorgan una protección efectiva a los derechos de los pueblos indígenas tal como lo sugiere el estándar internacional pertinente. Para ello, se estudiarán los parámetros internacionales establecidos por los diferentes estamentos con relación a las obligaciones que deben cumplirse para respetar el derecho de los pueblos indígenas de conocer y participar en los EISA. Posteriormente se plantearán dos momentos importantes, el primero consiste en explicar la normativa colombiana sobre el tema; el segundo, va dirigido a exponer situaciones generales y específicas donde se analiza la realidad que viven los pueblos indígenas en Colombia frente a la aplicación de los EISA.
Zakaz parkowania samochodów z instalacją LPG w garażach podziemnych - wybrane problemy
Authors: Porębska Joanna
Published: October 2019

Niemal wszechobecny zakaz wjazdu pojazdów zasilanych LPG do garaży podziemnych w budynkach mieszkalnych, biurowcach i galeriach handlowych wynika głównie z przepisów technicznych zlokalizowanych w akcie prawnym o randze rozporządzenia. Przepisy te budzą wiele wątpliwości zarówno wśród zobowiązanych kierowców, jak i wśród właścicieli nieruchomości objętych zakazem. Autorka analizuje zasadność wprowadzanych ograniczeń i komplementarność uregulowania tego zagadnienia oraz formułuje postulaty de lege ferenda.
Risk Factors of Recurrent Ischemic Events after Acute Noncardiogenic Ischemic Stroke
Authors: Zhang Limin , Li Xingang , Wang Dongzhi , Lv Hong , Si Xuezhong , Li Xiao , Sun Yuehong , Wang Dan , Chen Kelin , Kang Xixiong , Lou Xin , Zhang Guojun , Ma Ning
Published: October 2019

Background:

A considerable proportion of acute noncardiogenic ischemic stroke patients continue to
experience recurrent ischemic events after standard therapy.

Aim:

We aimed to identify risk factors for recurrent ischemic event prediction at an early stage.

Methods :

286 non-cardioembolic ischemic stroke patients with the onset of symptoms within 24 hours were
enrolled. Vascular risk factors, routine laboratory data on admission, thromboelastography test seven days after
clopidogrel therapy and any recurrent events within one year were assessed. Patients were divided into case group
(patients with clinical adverse events, including ischemic stokes, transient ischemic attack, myocardial infarction
and vascular related mortality) and control group (events-free patients). The risk of the recurrent ischemic events
was determined by the receiver operating characteristic curve and multivariable logistic regression analysis.

Results:

Clinical adverse events were observed in 43 patients (case group). The mean levels of Mean Platelet
Volume (MPV), Platelet/Lymphocyte Ratio (PLR), Lymphocyte Count (LY) and Fibrinogen (Fib) on admission
were significantly higher in the case group as compared to the control group (P<0.001). Seven days after clopidogrel
therapy, the ADP-induced platelet inhibition rate (ADP%) level was lower in the case group, while the
Maximum Amplitude (MA) level was higher in the case group as compared to the control group (P<0.01). The
Area Under the Curve (AUC) of receiver operating characteristic(ROC) curve of LY, PLR, , Fib, MA, ADP% and
MPV were 0.602, 0.614, 0.629, 0.770, 0.800 and 0.808, respectively. The logistic regression analysis showed that
MPV, ADP% and MA were indeed predictive factors.

Conclusion:

MPV, ADP% and MA were risk factors of recurrent ischemic events after acute noncardiogenic
ischemic stroke. Urgent assessment and individual drug therapy should be offered to these patients as soon as
possible.
High-Performance Low-Power 5:2 Compressor With 30 CNTFETs Using 32 nm Technology
Authors: Saini Jitendra Kumar , Srinivasulu Avireni , Kumawat Renu
Published: October 2019

Background:

The advent of High Performance Computing (HPC) applications and big data
applications has made it imparitive to develop hardware that can match the computing demands. In
such high performance systems, the high speed multipliers are the most sought after components. A
compressor is an important part of the multiplier; it plays a vital role in the performance of multiplier,
also it contributes to the efficiency enhancement of an arithmetic circuit. The 5:2 compressor circuit
design proposed here improves overall performance and efficiency of the arithmetic circuits in
terms of power consumption, delay and power delay product. The proposed 5:2 compressor circuit
was implemented using both CMOS and Carbon Nano Tube Field Effect Transistor (CNTFET) technologies
and it was observed that the proposed circuit has yielded better results with CNTFETs as
compared to MOSFETs.

Methods/Results:

The proposed 5:2 compressor circuit was designed with CMOS technology
simulated at 45 nm with voltage supply 1.0 V and compared it with the existing 5:2 compressor
designes to validate the improvements. Thereafter, the proposed design was implemented with CNTFET
technology at 32 nm and simulated with voltage supply 0.6 V. The comparision results of proposed
5:2 compressor with existing designs implemented using CMOS. The results also compare the
proposed design on CMOS and CNTFET technologies for parameters like power, delay, power delay
product.

Conclusion:

It can be concluded that the proposed 5:2 compressor gives better results as compared
to the existing 5:2 compressor designs implemeted using CMOS. The improvement in power, delay
and power delay product is approx 30%, 15% and 40% respectively. The proposed circuit of 5:2
compressor is also implemented using CNTFET technology and compared, which further enhances
the results by 30% (power consumption and PDP). Hence, the proposed circuit implemented using
CNTFET gives substantial improvements over the existing circuits.
ДИНАМІКА ПОКАЗНИКІВ ГІПЕРТРОФІЇ ТА РЕМОДЕЛЮВАННЯ ЛІВОГО ШЛУНОЧКА У ХВОРИХ З ДЕКОМПЕНСОВАНОЮ СЕРЦЕВОЮ НЕДОСТАТНІСТЮ В ПОСТІНФАРКТНОМУ ПЕРІОДІ ПІСЛЯ ПРОВЕДЕНОГО ВІДНОВНОГО ЛІКУВАННЯ
Authors: Вакалюк І. П. , Левандовська Х. В.
Published: October 2019

Обстежено 120 хворих з діагнозом Q-QS та не-Q інфаркт міокарда в яких зафіксована декомпенсована ХСН II А-Б стадії за класифікацією В. Х. Василенка та М. Д. Стражеска III-IV ФК (за NYHA). Хворі з діагнозом Q-QS інфаркт міокарда (60 пацієнтів) були сформовані у 4 групи в залежності від отриманих методів лікування: 1. 15 хворих, які отримували базову терапію, відповідно до протоколів МОЗ України, (лізиноприл 10 мг 1 раз на добу; бісопрололу фумарат 10 мг 1 раз на добу; еплеренон 50 мг 1 раз на добу; валсартан 40 мг 2 рази на добу; івабрадин 5 мг 2 рази на добу); 2. 15 хворих, які на фоні базової терапії отримували препарат янтарної кислоти за запропонованою схемою; 3. 15 хворих, які на фоні базової терапії отримували препарати аргініну за запропонованою схемою; 4. 15 хворих, які на фоні базової терапії отримували янтарну кислоту та препарати аргініну за запропонованою схемою. Аналогічно були сформовані у 4 групи пацієнти з діагнозом не-Q ІМ (60 пацієнтів). Тівортін (аргініну гідрохлорид фірми «Юрія-Фарм», Україна, Київ) затверджений Наказом МОЗ від 18.09.2008 р. № 528, реєстраційне номер UA/8954/01/01. Препарат призначали по 100 мл 4,5% розчину 1 раз на добу внутрішньовенно крапельно зі швидкістю 10 крапель за хвилину за перші 10-15 хвилин, потім швидкість введення збільшували до 30 крапель на хвилину (протягом перших 10 днів). Досліджені групи були однорідними за віком, статтю, важкістю перебігу захворювання, тривалістю постінфарктного періоду, наявністю клінічних проявів декомпенсації, що стало основою для включення осіб в дослідження. Ремоделювання серця, як відповідь до змін та реорганізації нормальної стуктури серця та судин, є хронічним неадаптивним процесом, який характеризується прогресуванням міокардіальної гіпертрофії, апоптозу, шлуночкової дилатації, фіброзу, судинної дисфункції [9]. Це стан, який може відноситись як до фізіологічних, так і патологічних процесів організму. Фізіологічне ремоделювання може розвиватись у відповідь на ріст, постійне фізичне навантаження, вагітність і характеризується запуском витончених та організованих адаптативних механізмів. Патологічне, у свою чергу розвивається в умовах запалення, ішемії, травми, біомеханічного стресу, як відповідь на надлишкову нейрогуморальну активацію та надмірне постнавантаження і є процесом структурних та функціональних змін лівого шлуночка у відповідь на внутрішнє чи зовнішнє серцево-судинне ураження і є попередником клінічної серцевої недостатності [1]. Постінфарктне ремоделювання є одним з найважливіших змін архітектури серця, що викликає гемодинамічний дисбаланс під впливом патологічних стимулів та біомеханічного стресу. Сам процес ремоделювання включає патологічні зміни структури, форми, розміру, маси та функції серця та його клітин [10]. Серцеве запалення, що виникає після перенесеного ІМ є основною рушійною силою відтермінованої регенерації кардіоміоцитів.
ОПТИМАЛЬНІ ПІДХОДИ ДО СУЧАСНИХ МОДИФІКАЦІЙ ОПЕРАЦІЇ МІЛЛІГАН-МОРГАНА В ЛІКУВАННІ УСКЛАДНЕНОГО ГЕМОРОЮ:
Authors: Соломчак П. В. , Скрипко В. Д. , Пасько А. Я.
Published: October 2019

Резюме. Незважаючи на швидкий розвиток малоінвазивних технологій в лікуванні геморою, операція запропонована E.Milligan і G.Morgan на сьогоднішній день залишається найбільш радикальним втручанням. Технічний прогрес та новітнє медичне обладнання сприяли широкому розвитку різноманітних модифікацій даного оперативного втручання, що спокунало нас до вивчення особливостей  використання електрокоагуляційного обладнання під час операції Мілліган-Моргана. В умовах хірургічного відділення ЦМКЛ м. Івано-Франківська за період  2016-2018 роки  оперативно оздоровлено 326 пацієнтів з третім  та четвертим ступенем геморою. Вивчено результати вираженості післяопераційного болю, тривалості перебування в стаціонарі і періоду реабілітації  в чотирьох групах, де проводилася геморойектомія за Мілліган-Морганом з застосуванням електрокоагуляційної установки фірми ERBEACC450 або високочастотного електрокоагулятора ЕК-300М1 та використанням пролонгованої епідуральної  анестезії впродовж першої доби після операції. На основі отриманих даних ми дійшли до наступних висновків, що використанням моно та біполярного струму електрохірургічного обладнання в проведенні операції Мілліган-Маргана  має переваги над класичними методами її проведення, суттєвої різниці у рівні больових відчуттів та тривалості перебування пацієнтів в стаціонарі при використанні застосованих нами електрокоагуляційних апаратів немає, однак повна епітелізація післяопераційних ран наступає швидше у пацієнтів, яким застосовано моно полярний електрод. Використання пролонгованої епідуральної анестезії впродовж перших 24 год. дозволило значно покращити психологічний комфорт пацієнтів та дозволило повністю відмовитися від використання ін’єкційних знеболюючих середників.
КОМПЕТЕНТНІСТНИЙ ПІДХІД У ВИКЛАДАННІ ВНУТРІШНЬОЇ МЕДИЦИНИ
Authors: Вацеба М. О.
Published: October 2019

Статтю присвячено проблемі компетентного викладання внутрішньої медицини у студентів ДВНЗ «Івано-Франківський національний медичний університет». У статті визначаються й обґрунтовуються теоретичні основи та практичні шляхи формування професійної компетентності майбутніх лікарів в умовах сучасної освіти. Зазначається, що для успішного формування професійної компетентності необхідне наступне: формування світогляду та спрямованості особистості, на основі яких відбувається засвоєння студентами знань й умінь; розвиток професійних здібностей у контексті набуття педагогічного досвіду; індивідуально-диференційований підхід у навчальному процесі. У роботі зазначено, що становлення особистості майбутнього фахівця, його професійної спрямованості не може відбуватися стихійно, цей процес вимагає наполегливої праці всіх викладачів. Успіх забезпечується точним знанням цілей та завдань виховання, врахуванням закономірностей, які визначають формування поглядів, переконань, культурних цінностей особистості, вибором ефективних методів і засобів навчання та виховання.

Висновки. У професійному розвитку провідним фактором є реалізація компетентнісного підходу. Компетентність фахівця дозволяє мобільно змінювати професійну діяльність за умов динамічного розвитку суспільства, втілення реформ професійної галузі
THE USE OF INFORMATION-EDUCATIONAL ENVIRONMENT OF REMOTE TRAINING OF STUDENTS OF HIGHER EDUCATION INSTITUTIONS
Authors: Mandzii T. P. , Kucheriavyi Yu. M. , Ragrina Z. M.
Published: October 2019

Abstract. Lately, the growing popularity of distance education: in 2014 on Google the most common search question was complete higher education. The development of education based on the principles of continuity, equal access, personal orientation forms a conceptually new model of education is "Open education". Therefore, the problem arises to use the appropriate modern educational technologies. The use of the information educational environment for student learning is one of the main implementations in institutions of higher education. The article presents the use of information and educational environment while training in the Ivano-Frankivsk national medical University and in the Zaporizhzhia state medical University, briefly discloses the use of Microsoft Office 365 and SharePoint. According to the developed questionnaire questioning of students of various forms of training and courses, interest in e-learning using Office 365 and summed up in the use of information and educational environment of the students of Ivano-Frankivsk national medical University and Zaporozhzhia state medical University.

Research methods: analysis was conducted on the basis of materials of scientific works of contemporary researchers in the field of cloud services, questionnaires, processing of online sources and modern literature to clarify how to use Office 365. During the research were used such methods as analysis of theoretical sources on the use of Internet resources in educational process, study and generalization of experience of organization of independent work of students using information-educational environment.

According to the Order of the MESU of April 25. 2013 №. 466 «On approving decree of distance education». Virtual education expands and updates the assignment of the teacher, make him a coach-consultant who shall coordinate the educational process, continually improve the courses that he teaches, increase creativity and skills in accordance with the innovations and innovation.

The questionnaire has been made for surveying students of full-time and part-time forms of education. The results of usage the virtual learning environment by students of the full-time and part-time form of education are presented due to the prepared strict questions.

After analyzing the forms of education and knowledge of students in the use of the material presented to them in Microsoft Office 365 and SharePoint, of course, it can be argued that the students of day form of education are more likely to use the site to prepare for couples and testing even at home.