bluuebunny/crossref_metadata_2025 huggingface dataset:
Role of serum hepcidin as a biochemical marker in children with Beta-thalassemia of iron status in Wasit Province Iraq
Authors: Attafi Fadhil J. , Rasheed Manal K.
Published: October 2022

β-thalassemia is characterized by anemia and depending on the severity of the anemia. Hepcidin is a 25-amino-acid peptide generated by the liver, based on hypoxia, anemia, and iron storage. controls blood iron concentration and tissue distribution and regulates the body's iron hemostasis. To evaluate the usefulness of Serum Hepcidin level as a biochemical marker of iron status in children with β thalassemia major, β thalassemia Intermedia and its relation with serum ferritin level. A cross-section study which will involve 90 included 50 Thalassemia Major (TM) and 40 Thalassemia Intermedia (TI). Patients will be collected from the thalassemia center in Kut Hospital for Gynecology and Pediatrics, were randomly selected for this study. All patients child in both gender from (5-17 years). Enzyme-linked immunosorbent assay [ELISA] used for determination of Hepcidin, Abbott Architect C4000 And cobas c 111 analyzer used for the determination of Ferritin, Iron and Hemoglobin was measured by Sysmex XP-300. The study included both gender 62.2% were male and 37.8% were females, regarding male gender 57.1% had βTM and 42.9% had βTI while female gender 52.9% had B-thalassemia major and 47.1% had β-thalassemia Intermedia.
A multi-centred study on knowledge of type 1 diabetes mellitus (T1DM) and adherence towards medications among caregivers of T1DM patients
Authors: Nasiruddin Aina Yazrin Ali , Kassab Yaman Walid , Azmi Siti Nabiella Noor , Shuhairil Sarah Ahmad
Published: October 2022

Type 1 Diabetes Mellitus, also known as insulin-dependent diabetes mellitus (IDDM), is a chronic disease caused by the autoimmune destruction of the pancreatic β cells, which function as insulin-producing cells. This study was aimed to assess the level of knowledge about T1DM and adherence to medications prescribed to T1DM patients at two different tertiary hospitals in Malaysia. This study was a hospital-based cross-sectional study conducted using self-administered questionnaire. The respondents were among caregivers of paediatrics patients with T1DM attending Paediatrics Clinics from both study sites . The study period was between January 2018 until December 2018 while the data collection period was conducted between May to August 2018. The mean age (SD) of the respondents were 41.07 (7.699). Studied samples were found to have good knowledge (mean=65.98, SD=12.62) and poor adherence (mean=60.08, SD=24.72). The correlation between knowledge score and adherence score among caregivers of T1DM patients showed that they were significantly correlated.  As for the association between adherence to medication and HbA1c level showed that they were insignificantly associated.
Physical activity and pregnancy related health outcomes in overweight and obese pregnant women: A systematic review and meta-analysis
Authors: Nordin Nurul Hanani Mohamad , Hashim Rosnani , Lian Leong Siew , Jamludin Nurul Ashikin
Published: October 2022

---Background Maternal overweight and obesity are considered as one of the obstetric risk factors of many health problems, and physical activity is viewed as one of the strategies in promoting a healthier pregnancy. Hence, the aim of this systematic review is to study the effects of physical activity on various pregnancy-related outcomes in overweight and obese pregnant women. Methodology Three online databases were searched for randomized controlled trials published between the years 2010 and 2021. The articles that reported the effect of physical activity on maternal and/or fetal outcomes were retrieved. The study characteristics and the data on health outcomes were extracted. Effect estimates were calculated using relative risk (RR), mean difference (MD), and standardized mean difference (SMD) with a random-effect model and 95% confidence interval (CI). Results Eleven studies were included for the statistical meta-analysis study. Physical activity was observed to significantly reduced GWG by 0.89 kg (95% CI = -1.63 to -0.14, P=0.02) and no significant results were found for other maternal and fetal outcomes measured. Conclusion Physical activity-only intervention shown to be beneficial in improving gestational weight gain, and appear to have promising results towards promoting good pregnancy-related health outcomes in overweight and obese pregnant women overall.
Knowledge and attitude of self-medication in acute pain among public in Cyberjaya, Selangor
Authors: Zamri Fauziah , Anatharaja Kitanjale
Published: October 2022

Pain is among the reasons that people self-medicate. Improved knowledge and good attitude toward self-medication, may limits the risks of self-medication. This study aims to determine the level of knowledge and attitude and also aimed to determine the association between knowledge and attitude as well as to study the level of knowledge and attitude of self-medication in acute pain among different demographic profile. This cross-sectional study conducted in Cyberjaya, Selangor, included 272 respondents sampled via convenient sampling method. The overall public knowledge and attitude on self-medication for acute pain is poor. There is a significant difference between the level of knowledge with ethnicity, educational background, and marital status (p < 0.05) .However, in the level of attitude, there is a significant difference with ethnicity, educational background; employment status and marital status (p < 0.05). There was a positive medium correlation between the level of knowledge and level of attitude in self-medication for acute pain (r = 0.39, p < 0.001). The public in Cyberjaya, Selangor has poor knowledge and attitude in self-medication for acute pain. Therefore, education can be given to the targeted group of the public regarding the proper way of treating acute pain in future.
Assessment of serum level of interleukin 33 in genital warts patients
Authors: Eyada Moustafa Mohamed Kamel , Attia Fadia Mostafa , Ismail Nader Ali , Moeen Nada Ahmed Moeen
Published: October 2022

Background: Genital warts (GWs) are highly prevalent sexually transmitted viral illnesses that are most prevalent in young, sexually active people of both sexes. Human papillomaviruses (HPV) cause GWs. The cytokine IL-33, an IL-1 family member, stimulates immune cells necessary for type 2 immune reactions. Immune cells like CD8+ T lymphocytes, neutrophils, and macrophages, Th1 cells, and B cells, and natural killer cells that are engaged in type-1 immunity, infection, and chronic inflammation are activated in part by IL-33. Aim: This study aims to examine whether there is a difference in levels of serum IL-33 between genital warts patients and healthy controls and its correlation with genital warts' characteristics. Subjects and Methods: Levels of serum IL-33 were assessed in 40 patients with GWs and 40 healthy control persons using enzyme-linked immune-sorbent assay kits. Results: Levels of serum IL-33 were significantly lower among patients with GWs compared to the control group (p= <.001). Patients with recurrent warts had slightly lower levels of these substances. Additionally, a modest inverse relationship between the quantity of warts and levels of serum IL-33 was found. Conclusion: patients with genital warts had considerably lower levels of serum IL-33 than normal controls.
Developing variable swimming technique skills among Iraqi schoolchildren during physical education courses
Authors: Hussain Mutaman Jabar Muhamed , Khudhair Karrar Abdulkareem , Jawad Ahmed Hameed
Published: October 2022

Variable education technology is now more prevalent in Iraq's higher education institutions, notably in physical education courses. The rise in the number of unwell people living in society stands out among the numerous unfavorable phenomena. Another is the decrease in physical activity brought on by technological development, which impacts people's capacity to improve their overall physical functionality and ability to develop their physical qualities. And physical health is the most valuable resource in any state, including Iraq. Thus it is crucial to find answers to the problems with physical education that affect students of all ages, especially young children. The project aims to develop and evaluate a method for teaching swimming to Iraqi kids in physical education classes while they are learning various skills. We selected several strategies to design a methodology for teaching swimming to Iraqi children in physical education classes. The approach used to categorize the study's results on the extent to which, among Iraqi students in the experimental and control groups, the essential physical features necessary for developing a variable capacity in teaching swimming had formed. The results were interpreted differently for each method.
apply some of programs (sports equipment, running, and diets) and its impact on the elders' weight, diastolic blood pressure
Authors: Alawady Ali Ahmed , Obaid Jawad Kadhim , Abdulrasool Mokhalad Dheyaa
Published: October 2022

The study aims to identify the Apply some of Programs (Sports Equipment, running, and diets) and its Impact on the Elders' Weight, Diastolic blood Pressure. The sample includes 48 elders and divided into (4) equal groups including the control group. Pretests and measures have been taken on Jan. 29th 2021 at 9:00 a.m and post tests and measures on April 18th 2021 at 9 : 00 a.m. Along 10 weeks, different programs are used in the experiments. The scores are handled statistically. The results revealed that there are differences of statistical significance of the study variables between the pretests and posttests. When we compare between groups and within the same group, there are differences of statistical significance in weight only. But there are no significant differences in diastolic and blood pressure due to the approximation of the three groups results.
Giving Oral Massage is Effective in Increasing the Suction Reflex Stimulus of LBW Babies
Authors: Yurita Noni , Jumari Jumari , Solihat Asep
Published: October 2022

Background: Low birth weight is a health problem that requires special attention in developing countries or countries with low socio-economic conditions. One of the impacts of LBW babies is the immaturity of the system in the body, including the baby's sucking reflex. The baby's sucking reflex in LBW has delay which has an impact on the growth and development of the baby.
Objectives: this study was to determine the effectiveness of oral massage on increasing the suction reflex of LBW at RS UMMI, Bogor.
Methods: Types of a quantitative method with a pre-experimental design and a one-group pre/post-test design with a total of 22 LBW respondents. Oral massage is given once a day for 15 minutes for 10 days
Results: The results showed that oral massage affected increasing the suction reflex of LBW with a marked increase in the mean value from 0 to 6, based on its development that on day 10 of the action, 100% of respondents already had a strong suction reflex.
Conclusion: The conclusion is that oral massage affects increasing the suction reflex of LBW.
Giving Warm Compresses with Progressive Muscle Relaxation Techniques Can Reduce Pain Intensity in Dysmenorrhea
Authors: Agustin Yuliana , Afrina Rina , Rukiah Nining
Published: October 2022

Background: Dysmenorrhea is a menstrual disorder in the form of severe pain or tenderness in the lower abdomen caused by the activity of prostaglandins, during menstruation the damaged uterine lining is expelled by new compounds called prostaglandins. Intervention in adolescent girls who experience dysmenorrhea can be done by non-pharmacological techniques, namely by warm compresses and progressive muscle relaxation.
Objectives: To determine the effectiveness of giving compressed warm with progressive muscle relaxation techniques to intense pain in dysmenorrhea.
Methods: This study used a quasi-experimental with a pre-posttest approach, and a non-equivalent control group design. The research instrument used on the compress variable warm with progressive muscle relaxation techniques, namely SOP (Standard Operational Procedure) and pain intensity variable, namely using the NRS (Numeric Rating Scale). The population in this study found 95 female students, the samples were taken using purposive sampling, and samples in research this group collects 54 female students who are calculated using the formula slovin and drop out a formula.
Results: Based on the results of statistical tests, namely the Mann Withney. Test obtained  p-value 0.187>0.05.
Conclusion: In this study, there were no significant differences between the warm compress intervention and the technique of progressive muscle relaxation or both have an effect on a decrease in pain intensity in the incidences of dysmenorrhea.
Hubungan Pola Makan, Aktifitas Fisik dan Media Informasi dengan Status Gizi Remaja
Authors: Farlina Merlin , Kusumastuti Istiana , Septiawan Catur
Published: October 2022

Background: Nutritional problems at this time are still one of the very concerning health problems, nutritional problems can be found in developing countries, one of which is Indonesia.
Objectives: This study aimed to determine the relationship between diet, physical activity, and information media with the nutritional status of adolescents at MA Nida Bahari Jampangkulon in 2021.
Method: This type of research used quantitative research, using a cross-sectional approach with analytical descriptive methods. The research population was all adolescents in MA Nida Bahari Jampangkulon, totaling 138 students and the research sample had as many as 58 respondents using the Random Sampling technique. The data was obtained from the Chi-Square test using SPSS.
Results: The results showed that there was a relationship between diet and nutritional status, p-value = 0.021 with an OR value of 4.073 (1,366-12,143), physical activity with nutritional status, p-value = 0.003 with an OR value of 6,139 (1,980-19036) and information media with nutritional status p-value. = 0.002 with an OR value of 6.429 (2.056-20.104).
Conclusion: This study concludes that there is a relationship between diet, physical activity, and information media with the nutritional status of adolescents at MA Nida Bahari Jampangkulon in 2021.
Hubungan Kecemasan Ibu Hamil, Sistem Rujukan Berjenjang BPJS dan Kualitas Pelayanan Masa Pandemi dengan Perilaku Kunjungan Antenatal Care di RSUD Kota Bogor Tahun 2022
Authors: Sulistiyo Sri , Noviyani Ernita Prima , Sumanti Nurwita Trisna
Published: October 2022

Latar Belakang: ANC atau antenatal care merupakan perawatan ibu dan janin selama masa kehamilan. Pentingnya  dilakukan kunjungan ANC, yaitu melalui ANC berbagai informasi serta edukasi terkait kehamilan dan persiapan persalinan bisa diberikan kepada ibu sedini mungkin.
Tujuan: Untuk mengetahui hubungan kecemasan ibu hamil, sistem rujukan berjenjang BPJS dan kualitas pelayanan masa pandemi dengan perilaku kunjungan ANC di RSUD Kota Bogor Tahun 2022.
Metode: Jenis penelitian ini, kuantitatif dan pendekatan deskriptif analitik dengan menggunakan metode cross-sectional. Populasi dan sampel penelitian adalah semua ibu hamil di RSUD Kota Bogor selama periode Februari 2022 sebanyak 135 responden. Teknik pengambilan sampel menggunakan purposive sampling. Alat ukur menggunakan kuesioner. Analisis data menggunakan chi-square dengan α 0,05.
Hasil: Hubungan antara kecemasan ibu hamil (P-value 0.023; OR 3,0), sistem rujukan berjenjang BPJS  (P-value 0.000; OR 12,5) dan kualitas pelayanan masa pandemi (P-value 0.000; OR 12,8) dengan perilaku kunjungan ANC  di  RSUD Kota Bogor  Tahun 2022.
Kesimpulan: Terdapat hubungan kecemasan ibu hamil, sistem rujukan berjenjang BPJS dan kualitas pelayanan masa pandemi dengan perilaku kunjungan ANC. Faktor sistem rujukan berjenjang BPJS merupakan salah satu faktor yang paling berhubungan kuat terhadap perilaku kunjungan ANC.
Self Efficacy dapat Meningkatkan Manajemen Perawatan Luka Gangren pada Pasien Diabetes Mellitus
Authors: Wikantana Wikantana
Published: October 2022

Introduction: Self Efficacy affects how a person thinks, feels self-motivated, and acts. Beliefs encourage self-control processes to maintain the behaviors needed to administer care. High self-confidence in diabetes mellitus patients is needed so that they have confidence and success in carrying out independent management. Individuals with high self-efficacy will be able to manage symptoms, treatment, physical changes, and lifestyle to adapt to their conditions.
Objectives: This study aims to determine the relationship between self-efficacy and management of gangrenous wound care in patients with diabetes mellitus.
Method: This type of research is quantitative with a cross-sectional approach. The design in this study used a correlation or correlation study with a total sampling of 40 respondents at the Bogor City Hospital. The instrument used was the Self Efficacy and Wound Care Management questionnaire sheet, which consisted of 40 questions. Then the data were analyzed using the Chi-Square test.
Result: The results of the analysis obtained a p-value = 0.022 which means p-value < 0.05 in other words there is a significant relationship between Wound Care Management and Self Efficacy.
Conclusion: This study concludes that there is a relationship between self-efficacy and management of gangrene wound care in patients with diabetes mellitus.
Implementasi Relaksasi Genggam Jari Pada Pasien Post Hernia Inguinalis Lateralis Sinistra Dengan Masalah Gangguan Nyeri dan Ketidaknyamanan
Authors: Irawan Didik Dhani , Wulandari Dwi Septi , Sukmaningtyas Wilis
Published: October 2022

Latar Belakang: Hernia inguinalis merupakan hernia yang terjadi penonjolan dibawah inguinalis, di daerah selangkangan atau skrotum. Pembedahan untuk menangani hernia menjadi salah satu cara yang lebih efektif karena metodenya yang konservatif (reposisi isi hernia inguinalis ke tempat semula). Nyeri menjadi salah satu masalah yang timbul pada pasien setelah dilakukan herniotomi dan hernioraphi selain gangguan mobilitas fisik, intoleransi aktivitas, dan resiko infeksi. Penatalaksanaan nyeri pada post operasi hernia dapat dilakukan secara non farmakoligis. Salah satu teknik relaksasi yang digunakan adalah teknik relaksasi genggam jari.
Tujuan: Mengetahui pengaruh relaksasi genggam jari terhadap nyeri post operasi pada asuhan keperawatan Tn.T dengan diagnosis Hernia Inguinalis Lateralis Sinistra (HILS) di Ruang Cendrawasih Bawah RSUD Ajibarang
Metode: Desain penelitian deskriptif dalam bentuk studi kasus dengan pendekatan proses keperawatan yang terdiri dari pengkajian, diagnosa keperawatan, perencanaan, pelaksanaan, dan evaluasi dengan memfokuskan implementasi keperawatan pada nyeri post Hernia Inguinalis Lateralis Sinistra (HILS) dengan memberikan relaksasi genggam jari. Adapun subjek studi kasus berjumlah satu kasus dengan masalah keperawatan nyeri post Hernia Inguinalis Lateralis Sinistra (HILS) di RSUD Ajibarang.
Hasil: Hasil penelitian menunjukkan skala nyeri pasien sebelum diberikan implementasi sebesar 5 sedangkan skala nyeri setelah diberikan implementasi relaksasi genggam jari selama 3 x 24 jam menjadi 3.
Kesimpulan: Tindakan keperawatan yang perlu dilakukan pada pasien meliputi mengidentifikasi lokasi, karakteristik, durasi, frekuensi, kualitas, intensitas nyeri, mengidentifikasi skala nyeri, mengidentifikasi respons nyeri non verbal, berikan teknik non farmakologis untuk mengurangi nyeri. Dari penelitian ini dapat disimpulkan implementasi keperawatan relaksasi genggam jari 3x24 jam dapat menurunkan skala nyeri pada pasien post operasi.
Implementasi Penggunaan Range Of Motion (ROM) Terhadap Kekuatan Otot Klien Stroke Non Hemoragik
Authors: Agustin Triyana , Susanti Indri Heri , Sumarni Tri
Published: October 2022

Latar Belakang: Stroke merupakan kondisi kematian sel saraf (nekrosis) otak yang disebabkan karena kegagalan dalam mensuplai darah. Penyakit ini menjadi salah satu masalah kesehatan neurologis yang perlu mendapatkan penanganan mendesak karena dapat mengakibatkan defisit neurologis. Komplikasi yang sering terjadi adalah kelumpuhan wajah atau anggota badan sebelah (hemiparesis) yang timbul secara mendadak, hingga terjadi penurun kesadaran.
Tujuan: Untuk menggambarkan asuhan keperawatan pada pasien Stroke non Hemoragik yang mengalami gangguan mobilitas fisik.
Metode: Penelitian ini merupakan penelitian studi kasus. Pengambilan sampel kasus menggunakan simple random sampling pada bulan April 2022. Subjek studi kasus menggunakan satu pasien yang terdiagnosa medis stroke non hemoragik yang mengalami gangguan mobilitas fisik di Ruang Assyifa RSI Banjarnegara. Peneliti menggunakan format pengkajian keperawatan dan pemeriksaan fisik. Peneliti melakukan proses asuhan keperawatan dimulai dari pengkajian hingga evaluasi selama 3 hari.
Hasil: Hasil didapatkan bahwa pasien mengeluhkan adanya kelemahan pada kaki dan tangan sebelah kanan saat melakukan aktivitas. Pasien memiliki riwayat hipertensi sejak 3 tahun yang lalu, serta jarang melakukan pemeriksaan. Tekanan darah 203/103 mmHg, nadi 97 kali per menit, irama nafas 20 kali per menit, dan suhu 36,9 0C. Bibir pucat, mukosa mulut kering. Diganosa medis tertulis pasien mengalami Stroke Non Hemoragik. Pemeriksaan ekstremitas didapatkan ektremitas kanan atas melemah nilai 2 dan ekstremitas kanan bawah melemah nilai 2, ekstremitas kiri atas dan bawah normal nilai 5 dan rentang gerak terbatas.
Kesimpulan: Berdasarkan data yang didapatkan, pasien mengalami gangguan mobilitas fisik. Peneliti memberikan intervensi ROM selama tiga hari, serta mengajarkan dan menjelaskan kepada keluarga  terkait dengan ROM. Tindakan ROM selama 3 hari menunjukkan adanya perubahan terhadap nilai rentang dari pasien, sehingga dapat disimpulkan pemberian tindakan ROM efektif untuk mengatasi gangguan mobilitas fisik.
Hubungan Pola Makan, Dukungan Suami dan Sumber Informasi terhadap Anemia pada Ibu Hamil di Usia Remaja
Authors: Trirahayu Selvia
Published: October 2022

Latar Belakang: Kehamilan di usia remaja dapat meningkatkan terjadinya risiko kematian sebanyak 2-4 kali lipat lebih tinggiidibandingkan dengan wanita yang hamil padaiusia 20-30 tahun. Hampir seluruh ibu hamil di Indonesia dapat mengalami anemia atauikekurangan darahisebanyak 48,9% ibu hamil di Indonesiaimengalami anemia. Persentase ibuihamil yang mengalami anemia di Indonesia mengalami peningkatan dibandingkan dengan tahun 2013 yaitu sebanyak 37,1%
Tujuan: Untuk mengetahui hubunganipola makan, dukungan suami dan sumber informasi terhadapianemia pada ibuihamil usia remaja.
Metode: Penelitian ini menggunakan pendekatan deskritif, populasi berjumlah 55 orang. Sampel yang digunakan dengan teknik purvosive sampling sebanyak 35 ibu hamil. Instrumen yangidigunakan yaituikuesioner kemudian di analisis dengan uji Chi- Square.
Hasil: Hasilipenelitian menunjukan hubunganipola makan dengan kejadian anemia nilaiiP (0,000) lebihikecil dari nilai αi (0,05). Hubungan dukungan suami denganikejadian anemia nilai P (0,003) lebih kecil dari nilai α (0,05). Hubungan sumberiinformasi dengan kejadianianemia nilai P (0,006) lebih kecil dari nilaiiα (0,05).
Kesimpulan: Berdasarkan hasil penelitian yang telah dilakukan tentang hubungan pola makan, dukungan suami dan sumber informasi terhadap anemia pada ibu hamil usia remaja di maka dapat disimpulkan bahwa, terdapat hubungan antara pola makan, dukungan suami dan sumber informasi dengan kejadian anemia ibu hamil pada masa remaja.
Efektivitas Pemberian Inhalasi pada Pasien Bronkopneumonia dengan Ketidakefektifan Bersihan Jalan Nafas
Authors: Hapsari Diana , Saroh Saroh , Nurfand Muhammad Sholahuddin
Published: October 2022

Latar Belakang: Bronkopneumonia adalah suatu cadangan pada parenkim paru yang meluas sampai bronkioli atau sering diartikan dengan peradangan yang terjadi pada jaringan paru melalui cara penyebaran langsung melalui saluran pernapasan atau melalui hematogen sampai bronkus. Pilihan terapi pada pasien dengan bronkopneumonia adalah Terapi inhalasi yang merupakan pemberian obat secara inhalasi (hirupan) kedalam saluran respiratori. Pemberian terapi inhalasi yaitu teknik yang dilakukan dengan pemberian uap dengan menggunakan obat combiven 1 ampul dan Pulmicort. Obat combiven adalah obat yang digunakan untuk membantu mengencerkan sekret yang diberikan dengan cara diuap dan Pulmicort digunakan untuk mengenerkan sekret yang terdapat dalam bronkus.
Tujuan: Bertujuan untuk mengetahui efektifitas pemberian inhalasi pada pasien bronkopneumonia dengan ketidakefektifan bersihan jalan nafas
Metode: Desain pada penelitian ini adalah dengan rancangan studi kasus menggunakan pendekatan proses keperawatan. Sampel pada penelitian ini adalah Ny.U dengan pneumonia di bangsal Alamanda lantai 11. Pengumpulan data dilakukan dengan wawancara kepada pasien dan keluarga, melakukan observasi, melakukan pemeriksaan fisik  dan melihat catatan perkembangan dari rekam medik pasien selama tiga hari dimulai dari pengkajian sampai dengan evaluasi.
Hasil: Setelah dilakukan tindakan selama 3 hari dengan  terapi inhalasi nebulezer dilanjutkan dengan combivent 3x sehari dan Pulmicort 2x sehari frekuensi nafas Ny. U menjadi 20x/menit dengan saturasi 97% room Air, batuk berdahak berkurang dan nafas menjadi normal.
Kesimpulan: Hasil dari penelitian ini menunjukan adanya efektifitas pemberian inhalasi pada pasien bronkopneumonia dengan ketidakefektifan bersihan jalan nafas. yang ditandai setelah dilakukan tindakan selam 3 hari ferkuensi nafas menjadi normal, dan batuk berdahak berkurang
Application Research on Enhancing the Cognitive Ability of Art Appreciation of Senior High School Students in Chengdu through Virtual Reality Technology
Authors: Liu Pei , Phongsatha Satha
Published: October 2022

The application of virtual reality technology in art appreciation teaching can effectively guide students to recognize and appreciate art works from the visual, auditory and tactile aspects. By simulating the reproduction of the real scene of art works, the students' cognitive ability and appreciation ability of art appreciation can be improved. This paper aims to apply virtual reality technology to art appreciation teaching, improve students' cognitive ability of art appreciation, and adopt the quantitative and qualitative modes of research. This quasi-experimental study uses pre-test and post-test, and uses two different methods of traditional teaching modes and virtual reality technology teaching mode to compare the test results of the cognitive ability of art appreciation two groups of students. The data were analyzed by mean and standard deviation, and the research hypothesis was tested by independent sample t-test and paired sample t-test. The hypothesis test results showed that the students in the experimental group achieved good results in the test of virtual reality technology applied to art appreciation. Finally, the qualitative data of face-to-face interviews reflect the positive evaluation of the technology and the satisfaction of improving the cognitive ability of art appreciation. The main survey structure shows that art appreciation learning combined with virtual reality technology is effective and could be considered as a useful technical tool. It gives students the opportunity to learn and practice more comprehensively in the art class, thus improving their cognitive and aesthetic abilities.
Electrical myotonia and antibiotic induced myasthenic crises: A novel CHRNE variant
Authors: Sim Jingwei , Narasimhalu Kaavya
Published: October 2022

We describe a middle-aged lady who had developed childhood-onset chronic progressive external ophthalmoplegia, fatigable ptosis, and myopathic facies. Unique features of her clinical phenotype included facial weakness that failed to respond to treatment, exacerbation with antibiotic use and electrical myotonia. She responded well to 3,4-diaminopyridine. We highlight aspects of her presentation that led to clinical diagnosis – and, ultimately, genetic confirmation – of a congenital myasthenic syndrome. This underscores the importance of taking a family history and considering inherited causes in cases of seronegative myasthenia.
Retinal nerve fiber layer thickness and visual aura mechanism in patients with vestibular migraine with or without white matter lesions
Authors: Yu Shen , Defu Li , Mengyao Hu , Qian Cao , Zhuo Hou , Lijun Xu
Published: October 2022

Background & Objective: The pathogenesis of vestibular migraine (VM) is still unclear. A considerable proportion of patients with VM have white matter lesions (WMLs). We sought to determine whether the presence of WMLs was related to the thickness of the retinal nerve fiber layer (RNFL) in VM patients. We also investigated the relationship of visual aura to the thickness of the RNFL and explored the possible mechanisms of visual aura.
Methods: This study was a large single-center, prospective, controlled study. A total of 50 patients with VM with or without visual aura and 50 healthy controls were recruited. We assessed WMLs using cranial magnetic resonance imaging (MRI) and measured RNFL thickness using optical coherence tomography (OCT). The relationship between RNFL thickness and WMLs was analyzed. RNFL thicknesses for the aura group, non-aura group and control group were compared.
Results: (1) The RNFL of the VM group was significantly thinner than that of the control group. (2) When VM patients were divided into two groups based on the presence or absence of WMLs, the RNFL of VM patients with WMLs was significantly thinner, while the RNFL of VM patients without WMLs was significantly thicker, than that of the controls. (3) When the VM group with WMLs was subdivided into two groups according to the presence or absence of visual aura, we found no significant difference in the RNFL thickness of the subgroups with and without visual aura. However, the RNFL thickness of the control group was significantly greater than that of the VM with WML groups with or without visual aura. (4) Finally, when the VM group without WMLs was subdivided into two groups according to the presence or absence of visual aura, there was no significant difference between the RNFL thicknesses of the 2 subgroups. The RNFL thickness of VM patients without WMLs with and without visual aura was greater than that of the control group.
Conclusion: Among VM patients, RNFL thinning is positively correlated with the presence of WMLs, while visual aura symptoms are not significantly related to RNFL thickness, indicating that the mechanism of visual aura may not be a disorder of the vascular system. If WMLs develop in VM patients in the future, repeated assessment to look for an associated decrease in RNFL thickness may be helpful.
Is serum NSE a useful biomarker in multiple system atrophy?
Authors: Zhang Qiaoqiao , Jin Long
Published: October 2022

Objective: Multiple system atrophy (MSA) is a rapidly progressive and devastating neurodegenerative disease with limited lifespan. Biomarkers in diagnosing and evaluating the prognosis of MSA is a rapidly developing field. Neuron-specific enolase (NSE) is a biomarker of neuronal damage applicable in many neurological disorders. This study aimed to determine the usefulness of serum NSE as biomarker of MSA.
Methods: In this case-control study involving 50 patients with MSA, electrochemiluminescence assay was used to investigate whether serum NSE levels. The disease severity of patients was assessed by Unified System Atrophy Rating Scale (UMSARS part II). The correlation between NSE levels and clinical features in MSA patients was analyzed.
Results: The NSE levels were higher in MSA patients (11.59±2.52 ng/mL) than the control group (11.30±2.73 ng/mL); however, the difference was not statistically significant (P=0.581). In addition, no statistically significant difference was detected in the NSE levels between the parkinsonian (MSA-P) and cerebellar subtypes (MSA-C). No distinct difference was also detected between males and females of MSA patients. Furthermore, no correlations were established between NSE levels and age, disease duration, and UMSARS II score.
Conclusions: This study suggest that serum NSE is not a useful biomarker of MSA. Future studies should examine whether there is a role for CSF NSE in reflecting neuronal damage in MSA patients.
Retrospective analysis of autonomic dysfunction in epilepsy patients from neurophysiological recordings
Authors: Rahul Shridharani Akash , Harilal Parasuram  , Balaraman Mrudula , Bhaskaran Renjitha , Kumar Anand , Gopinath Siby
Published: October 2022

Autonomic dysfunction is often associated with seizures in patients with epilepsy. Autonomic dysfunction during seizures can cause serious events like cardiac arrest and sudden unexplained death. Early detection of autonomic dysfunction is crucial to avoid such medical emergencies. In our study, we analyzed the heart rate variability (HRV) in physiological recording during the preictal, ictal and postictal periods. A total of 142 seizures with various semiologies recorded from 49 epilepsy patients were included. Time-domain measurements including mean hear rate (HR), RR interval (RRI), root-mean-square of successive R-R interval differences (RMSSD), The standard deviation of N-N intervals (SDNN) and percentage of successive RR intervals that differ by more than 50 ms(pNN50) were analyzed at different time points, 20 minutes before the seizure, 1 minute before the seizure, during the seizure and 20 minutes after the seizure. We observed there was a significant difference in HRV parameters during and just before the seizure onset (RMSSD with p-value<0.001 and SDNN with p-value<0.001). We also observed that there was a suppression of parasympathetic activity and activation of sympathetic stimulation in the ictal and peri-ictal period, which was characterized by an elevation in the mean heart rate (HR), whereas the mean RRI showed an inversely proportional trend. There was a reduction in mean RMSSD, SDNN and pNN50 prior to seizure onset and was more pronounced in generalized seizures as compared to focal seizures with preserved or impaired awareness. There was a greater sympathetic activation and parasympathetic inhibition during an epileptic seizure in females as compared to male patients. These findings suggest that autonomic dysregulation was increased during a generalized seizure when compared to a focal seizure. HRV analysis can be used as a valid method for quantifying central influences on the autonomic nervous system and its cardiac control. A major advantage of electrocardiogram (ECG)-based seizure detection is that the ECG is an essentially easier signal to obtain, with a higher signal-to-noise ratio than EEG (electroencephalogram). Based on the inferences from this study future studies could be done to build machine learning models which could form the base for the development of wearable seizure prediction devices.
Agranulocytosis following intravenous immunoglobulin administration in a patient with Guillain-Barré Syndrome triggered by COVID-19: A case report
Authors: Djikić Marina , Ždraljević Mirjana , Miladinović Tijana , Milenković Marija , Berisavac Ivana
Published: October 2022

Neutropenia during recovery after coronavirus disease 2019 (COVID-19), as well as neutropenia after intravenous immunoglobulin (IVIG) administration are very rare hematological abnormalities. We report the first case of agranulocytosis following IVIG administration in patients with Guillain-Barre syndrome (GBS) triggered by COVID-19. A 62-year-old female patient was admitted to the Emergency Department due to progressive limb weakness and sensory disturbances that began two weeks before admission. Five weeks before admission she was treated for COVID-19 and has fully recovered. She was diagnosed with Guillain-Barre syndrome (GBS), and treatment with IVIG was started. Twenty hours after the first dose of IVIG, blood analysis showed neutropenia and thrombocytopenia, and after the fifth dose she developed agranulocytosis followed by mild increase in body temperature. Granulocyte colony-stimulating factor (G-CSF) was administered and after 12 hours the leukocyte lineage recovered. According to the previous findings, neutropenia after IVIG administration might be related to CD11b, and COVID-19 is associated with an increase in immature neutrophil populations in the later stages of the disease defined by their expression of CD11b. Meanwhile, some finding suggests that corticosteroid pretreatment prevent neutropenia after IVIG administration, which might be important because many patients with post-COVID GBS have been treated with corticosteroids for COVID-19.
Burning chest pain as a prodromal sign in autopsy- proven Parkinson’s disease dementia
Authors: Yoo Dallah , Park Sung-Hye , Kim Man Jin , Ahn Tae-Beom
Published: October 2022

Pain is common in Parkinson’s disease (PD) from its early phase. However, there are no reports of autopsy-proven PD dementia with unusual pain. We report the case of a woman with PD dementia who initially presented with unyielding central neuropathic chest pain and parkinsonism. Diagnostic workup showed no abnormal findings related to her pain. Although her parkinsonism was responsive to dopaminergic medication, her clinical status rapidly deteriorated to dementia with hallucinations and delusions over 2 years. An autopsy was performed following death after 6 years of disease. Pathologic examination revealed diffuse Lewy body pathologies (Braak stage VI), limbic-predominant Alzheimer’s disease pathology, and TAR DNA-binding protein 43 pathologies in the amygdala. The patient was an APOE4 carrier. Multiple pathologies concurrent with the APOE4 allele might be associated with rapid clinical deterioration. Although pathologic substrates for pain remain uncertain, the initial presentation of unusual pain merits further clinicopathological correlation studies.
The knowledge level of health sciences students about epilepsy and its relationship with attitudes towards epilepsy in Turkey
Authors: Eren Fettah , Guzel Serife
Published: October 2022

Background & Objectives: Although epilepsy is one of the most prevalent diseases, it is highly surrounded by stigmatization and negative attitudes toward epilepsy. Due to numerous incorrect or insufficient knowledge attributed to epilepsy, people have negative attitudes against the disease. This study was performed to examine the knowledge levels and attitudes about epilepsy of undergraduate students studying at the faculty of health sciences in Turkey.
Methods: In the study, the epilepsy knowledge level and attitudes towards epilepsy and the person with epilepsy were evaluated in 1,019 students studying at the faculty of health sciences at Konya Selcuk University. The scales of epilepsy knowledge and attitudes towards epilepsy were transformed into an online form and sent to participants’ e-mail addresses.
Results: Two hundred eighty (27.5%) students read scientific documents about epilepsy. Especially those who read textbooks and scientific articles/research articles had a higher level of knowledge (p = 0.002). The least well-known issue was related to the treatment of the disease. Although most students had a high level of epilepsy knowledge, they had negative attitudes especially toward dating and marriage with epileptic individuals. Female, clinical students, those who witnessed epileptic seizures, and those who had a higher level of knowledge about epilepsy had more positive attitudes towards epilepsy (p < 0.05).
Conclusion: Negative attitudes towards epilepsy patients still exist among health science students in Turkey. Health sciences faculty education programs should be designed to increase the epilepsy awareness of students. Increasing the level of knowledge and awareness may lead to better attitudes.
Hospital admissions of spontaneous subarachnoid hemorrhage during the COVID-19 pandemic: Southeastern Turkey experience
Authors: BAŞAR İbrahim , BAHADIR Sinan , YILMAZ Tevfik
Published: October 2022

Objective: This study aimed to determine if the coronavirus disease 2019 (COVID-19) pandemic had any impact on admission patterns for subarachnoid hemorrhage (SAH) during 1st and 2nd waves and in-between in a tertiary institution in southeastern Turkey.
Methods: Three periods were determined during the pandemic: First and second peaks (April 1-May 1, 2020 and November 18-December 18, 2020, respectively) and the slowdown period (July 5-August 4, 2020) where the daily new cases hit its lowest. We retrospectively collected data of the patients with SAH who were admitted to our institution within these periods during 2020 (the pandemic) and 2019 (the year before the pandemic). Demographic data, time between symptom onset and admission, Glasgow Coma Scale (GCS), Fisher score, World Federation of Neurosurgical Societies (WFNS), presence of intracerebral hemorrhage, intraventricular hemorrhage, hydrocephalus, type of SAH (aneurysmal vs non-aneurysmal) were recorded and compared between the pandemic and pre-pandemic periods.
Results: The number of admissions in first peak, slowdown, and second peak during the pandemic was 11, 15, and 17, respectively. They did not differ significantly from corresponding periods in 2019 (17, 7, and 10, respectively) (all P>0.05). The mean time from onset to admission to hospital was similar between pandemic and 2019 (ranging between 0.40-2.00 days in 2020 compared to ranging between 1.12-2.29 days in 2019). The rate of cases with worse neurological condition on admission turned out to be lower during the first peak of the pandemic compared to previous year (9.1% vs 29.4%, P=0.029), but showed no difference in the remaining two periods. The incidence of accompanying pathologies (intracerebral hemorrhage, intraventricular hemorrhage, and hydrocephalus) was also similar between the periods in 2020 and their counterparts in 2019. Rate of non-aneurysmal cases ranged between 11.1%-45.5% in 2020 compared to 10.0%-57.1% in 2019 (all P>0.05).
Conclusion: The study showed that hospital admission patterns for SAH was not affected by COVID-19 pandemic in the southeastern Turkey, unlike other reports. This may be due to different behavioral characteristics of the study population and capability of health care system to cope with high number of patient admissions.
Association between sleep duration and cardiovascular disease specific mortality: A meta-analysis
Authors: Ye Feicheng , Liu Jing , Zhang Shuguang , Han Xu
Published: October 2022

Backgrounds: In this systemic review and meta-analysis, we concentrated on the association between sleep duration and cardiovascular disease (CVD) mortality because existing studies results were inconsistent.
Methods: We searched for articles published before December 2021 in databases (PubMed and Web of Science). We used STATA 12.0 software to compute hazard ratios (HRs) with their 95% confidence intervals (CIs) to create a pooled effect size and 95% CI.
Results: The meta-analysis showed that short sleep duration (<7 hours/day) was associated with an increased CVD specific mortality, compared to normal sleep duration with a random effects model (HR = 1.12, 95% CI 1.08 to 1.16, I2 = 38.6%, p = 0.002). The meta-analysis showed that long sleep duration (>7 hours/day) was associated with an increased CVD specific mortality, compared to normal sleep duration with a random effects model (HR = 1.23, 95% CI 1.18 to 1.29, I2 = 65.2%, p < 0.001).
Conclusions: We found that sleep duration that is either too short or too long is significantly associated with higher risk of CVD mortality. More relevant factors about sleep are needed to be evaluated on the associations between sleep and CVD. Further large-scale, well-designed, randomized controlled trials are needed to explore the associations.
Ploščad’ Peremen, Minsk: arte e canzone come forme di resistenza
Authors: Mini Riccardo
Published: October 2022

Il presente articolo si propone di illustrare il sorgere e lo sviluppo della realtà di Ploščad’ Peremen a Minsk nel contesto delle proteste bielorusse, iniziate nell’agosto 2020. Ploščad’ Peremen è spazio di resistenza, luogo di aggregazione e di protesta alternativa. Situato in un cortile di ulica Červjakova, sorge in seguito al gesto sovversivo dei dj Kirill Galanov e Vladislav Sokolovskij, che in occasione di un concerto governativo suonano Peremen dei Kino, inno al cambiamento, venendo poi arrestati. In Ploščad’ Peremen la protesta si esprime attraverso serate danzanti, spettacoli teatrali, dipinti, murales e soprattutto concerti. Si vuole analizzare il valore e il significato di quattro canzoni ricorrenti: Peremen dei Kino, scritta da Viktor Coj nel 1989, Steny ruchnut, versione russa dell’inno della Solidarność, composto da Jacek Kaczmarski nel 1980, Vychodi guljat’ del gruppo hip hop russo Kasta, uscita a gennaio 2020, e infine My ne narodec del gruppo rock bielorusso Tor Band, rilasciata nel giugno di quest’anno. Si evidenzia il significato originario delle canzoni sopracitate, e come e perché le stesse abbiano acquisito importanza e valore all’interno del movimento di protesta bielorusso. Accanto all’analisi delle canzoni verrà evidenziato il ruolo di Telegram come nuovo canale di comunicazione e organizzazione delle proteste.
Una sensibilità umana nel giocattolo animale: Riflessioni tra postumanismo, resilienza e children’s literature
Authors: Moja Beatrice
Published: October 2022

I giocattoli con tratti fisici non antropomorfizzati in letteratura, specie quando rivolta a un pubblico infantile, si rivelano come un utile strumento per riflettere sulla distinzione tra ‘umano’ e ‘non umano’. Il corpo artificiale del giocattolo e la caratterizzazione animale incarnano, infatti, in modo evidente il concetto di alterità rispetto all’idea stereotipica di umanità. Ispirati dalle vicende narrate, i giovani lettori possono trarre degli essenziali insegnamenti, quali le capacità di empatia e di resilienza ai traumi di piccola o grande entità che ciascuno può incontrare nel corso della vita. L’introduzione critica a queste riflessioni è completata dall’analisi letteraria circa la caratterizzazione dei giocattoli in alcuni testi per l’infanzia: il giocattolo-coniglio in The Velveteen Rabbit (1922) di Margery Williams, i giocattoli-topi in The Mouse and His Child (1967) di Russell Hoban e il giocattolo-orso in Winnie-the-Pooh (1926) di A. A. Milne.
Tra stereotipo e identità: lo sguardo di Theodor Wonja Michael sulla Germania del Novecento
Authors: Ottavio Francesca
Published: October 2022

Le dinamiche che regolano la convivenza tra persone e gruppi culturali dimostrano come la società contemporanea rimanga ancora legata ai pregiudizi del passato. Particolarmente problematico diventa lo scarto tra chi, nato e cresciuto in Europa, non viene accettato come parte della comunità per via di tratti somatici dissimili rispetto al modello nazionale. La questione è analizzata a partire dal volume autobiografico di Theodor Wonja Michael, giornalista e attore vissuto all’insegna della resilienza. Il suo corpo, reso vulnerabile dal colore della pelle e dall’eredità camerunense, ha saputo reagire ogni volta al rifiuto di una Germania che, per anni, ha preteso di parlare al suo posto, imponendogli di figurare nelle vesti del selvaggio nei celebri zoo umani (Völkerschauen), nonostante il suo forte sentimento di appartenenza tedesco. Le vicende della storia permettono di riflettere sui principi che regolano la costruzione dell’immagine stereotipata del ‘noi’ e dell’‘altro’ e sugli strumenti pratici, impiegati a sostegno di tali idee. Deutsch sein und schwarz dazu (“Essere tedesco e in più nero“, 2015) racconta la storia di un uomo e, al tempo stesso, di un gruppo di individui defraudati delle loro identità per incarnare i pregiudizi dei tempi.
GAN-Generated Terrain for Game Assets
Authors:   Director, Department of Machine Learning, Conga, Thane (Maharashtra), India., Sisodia Yogendra
Published: October 2022

Multimedia applications, such as virtual reality models and video games, are increasingly interested in the ability to generate and author realistic virtual terrain automatically. In this paper, the author proposes a pipeline for a realistic two-dimensional terrain authoring framework that is powered by several different generative models that are applied one after the other. Two-dimensional role-playing games will benefit from this ability to create multiple high-resolution terrain variants from a single input image and to interpolate between terrains while keeping the terrains that are generated close to how the data is distributed in the real world.