bluuebunny/crossref_metadata_2025 huggingface dataset:
CYTOKINE TISSUE PROFILE IN NON-METASTATIC GASTRIC CANCER
Authors: Sagakyants A. , Kit Oleg , Zlatnik Ye. , Zolotarev Ye. , Shulgina O. , Novikova I. , Samoylenko N. , Soldatkina N. , Gevorkyan Yuriy , Sidorenko Yu.
Published: November 2020

The development of the tumor process involves the involvement of various functional elements of innate and adaptive immunity. A special role in the reorganization of tissues, changes and evolution of the properties of cancer cells is given to cytokines, the study of the role of which in these processes with various types of neoplasms and, in particular, with nonmetastatic gastric cancer is an urgent task.
The aim of the work was to determine the characteristics of the cytokine status in the tissues of patients with non-metastatic gastric cancer.
Materials and methods. In the extracts of tumor tissue, perifocal zone, omentum, peritoneum of patients with gastric cancer without metatstases (T3-4aN0-3M0, n = 20, 58.9 ± 9.7 years), the concentration of IL-1P, IL-2, IL -6, IL-8, IL-18, TNF-a, IL-10 and IL-1RA in tumor tissue, the perifocal zone, as well as in the omentum and peritoneum.
Results and discussion. In the tumor tissue, an increase in the content of IL-1P, IL-8 and a decrease in IL-2, TNF-a and IL-10 were noted. In the perifocal zone, a decrease in the concentration of IL-1P, IL-6, IL-8 was revealed with an increased content of IL-2, IL-1RA, IL-10, TNF-a and IL-18. Against this background, the omentum and peritoneum compared with the tumor, the concentration of IL-1P, IL-18 and IL-1RA is reduced, against the background of an increase in the concentration of IL-2, IL-6, TNF-a and IL-10.
Findings. It was shown that tumor tissue has some features in the cytokine profile compared with unaffected tissues, which can be used to further evaluate the development of the pathological process.
IS A STUDY OF THE LEVEL OF CARBOHYDRATE ANTIGEN (CA 19-9) EFFECTIVE IN PATIENTS WITH COLORECTAL CANCER?
Authors: Rybakov Ye. , Tarasov Mikhail , Chernyshov S. , Sukhina Marina , Charikov V. , Kozyreva Sabina , Kashnikov V.
Published: November 2020

Objective. Саrbohydrаte antigen 19-9 (CA 19-9) is the frequently used tumor marker in the clinical setting of colorectal cancer (CRC). This study was designed to investigate the correlation between preoperative serum levels of CA 19-9 (pre-CA 19-9) and the clinicopathologic factors of patients with CRC.
Patients and methods. A study was performed on 482 patients with histologically diagnosed colorectal adenocarcinoma between January 2016 and December 2017, based on retrospective collected data. The clinical data such as age, sex, size of tumor, differentiation (G), depth of tumor (T), lymph node metastasis (N), distant metastasis (M), lymphatic invasion, venous invasion, perineural invasion, stage, and preoperative serum levels of CEA (pre-CEA) and pre-CA 19-9 were obtained. These patients were classified into two groups according to pre-CA 19-9 (CA 19-9 high: H37 U/mL; CA 19-9 normal: H37 U/mL).
Results. Eighty five patients among 483 patients (17.6%) with CRC showed a high pre-CA 19-9. The elevationof pre-CA 19-9 was significantly associated with size of tumor > 4.5 cm (р=0.0001), higt CEA > 5ng/ml (р<0.0001), wrong differenciation of tumor (р=0.0003), depth of tumor (р<0.0001), lymph node metastasis (р<0.0001), distant metastasis (р<0.0001), lymphatic invasion (р=0.0013), vascular invasion (р<0.0001), perineural invasion (р<0.0001), stage (р<0.0001). On multivariate analysis, high pre-CA 19-9 was shown to be independently associated with depth of tumor (р=0.05), lymph node metastasis (р=0.0006). Spearman>s correlation coefficient r between REA and CA 19-9 was 0.21 (95% CI 0.13 - 0.30; p<0.0001).
Conclusion. High pre-CA 19-9 in advanced colorectal cancer might provide important information to predict the depth of tumor, lymph node metastasis.
THE EFFECT OF TUMOR STEM CELLS ON PROGNOSIS FOR LOCALIZED MELANOMA OF THE SKIN
Authors: Titov K. , Kazakov A. , Baryshnikova M. , Markin A.
Published: November 2020

Objective: to determine the prognostic value of tumor stem cells in patients with primary stage I-II skin melanoma.
Materials and methods: The study was conducted on surgical material from 48 patients with an established diagnosis of stage I-II skin melanoma. Planned histological examination of the material was carried out according to routine technology with an assessment of: type of melanoma, thickness (Breslow), invasion (according to Clark), the presence or absence of ulceration, the severity of lymphoid infiltration. For immunohistochemical studies, the expression of ABCB5 and CD133 markers was carried out with monoclonal antibodies: CD133 (rabbit polyclonal to human CD133, 1: 100 dilution, ab19898, Abcam) and ABCB5 (5H3C6 clone, 1: 200 dilution, ab140667, Abcam), incubation with antibodies at 4 ° С 16-18 hours. Expression was evaluated using a point scale of intensity (0, 1+, 2+, 3+) and the percentage (0-100%) of positive cells among all tumor cells in the sample. The statistical significance of the results was estimated by calculating the correlation coefficient by the rank method (Spearman’s method).
Results: a statistically significant relationship was found between the presence of stem cell markers of melanoma tumors and 2-year overall and relapse-free survival, as well as a correlation between the presence of CSCs and a number of morphological characters.
Conclusions: the presence of tumor stem cell markers affects the 2-year prognosis in patients with primary stage I-II skin melanoma. In addition, the presence of CSCs is associated with a larger thickness of the tumor according to Breslow and a higher level of Clark invasion, more pronounced lymphoid infiltration. These data can improve the prognosis and diagnosis of patients with localized melanoma of the skin.
RADIOSURGERY OF BRAIN METASTASES: RETROSPECTIVE ANALYSIS OF 5 YEAR RESULTS
Authors: Girshovich M. , Ponomareva O. , Melnik Yu. , Novikov S. , Khrapovitskaya Ye. , Kanaev Sergey
Published: November 2020

In 5 year 180 patients (89 men and 91 women) underwent radiosurgery of brain metastases. Most patients had breast cancer and less than 5 lesions. Median overall survival (MOS) was 12,5 months, median progression free survival (MPFS) - 6,1 months. Both values were higher in patients with solitary lesions: 22.5 vs 10 months (р=0.00703) and 9 vs 6 months (р=0.02787), respectively.MOS was 18 in women with breast cancer, 12 months in patients with non small cell lung cancer. 8 - with melanoma and only 4 months - for small cell lung cancer. MPFS was significantly shorter for lesions volumes above 15 cm3. In field progression was detected in 37 (2-24 months after treatment) of 180 cases (20,5%). Second radiosurgery was performed in 24 cases.
THE TREATENT OF PRIMARY MULTIPLE CANCER IN A PATIENT WITH A KIDNEY GRAFT. CLINICAL INCIDENCE
Authors: Belova Ye. , Belov A. , Sokurenko V. , Kuznetsov A. , Anokhina A. , Shkolnik M. , Gerasimova O. , Semenova Ye.
Published: November 2020

Treatment of tumors in kidney recipients is not an easy task, due to lifelong immunosuppression. The leading place among all graft tumors is skin cancer - 31%, and the 3rd place is occupied by tumors of the genitourinary system (0.35.8%). The main method of treating skin cancer is surgical, which is difficult to perform in some localities. An alternative method is radiation therapy. The tumor in the graft is rare. The method of treating a tumor of this localization is surgical, which can lead to nephrectomy of the graft. Radiofrequency-assisted graft resection is an original treatment method. Its use provides good immediate and long-term treatment results. Patient B., born in 1977, 20.10.2016 was diagnosed with a tumor in kidney graft T1aN0M0 (stage I). Allotransplantation of the kidney to the left iliac vessels from 15.01.2012. When choosing the method, there were difficulties: an obese patient, graft eventration in anamnesis, according to MSCT, intestinal loops are located around the kidney graft, and fibrous changes around the kidney graft. Laparoscopic radiofrequency - assisted renal graft resection was chosen as the method of treatment. Operation duration-120 minutes, blood loss-100 ml. The postoperative period was uneventful. Currently, there are no signs of relapse. In June 2019-the appearance of a skin formation in the area of the left auricle, histologically-squamous cell cancer, G III. From 12.07.2019-short-focus radiation therapy with ROD 3 G, SOD 54 G. The treatment was carried out satisfactorily. In October 2019-a similar formation on the skin of the left cheek. From 14.11.2019-short-focus radiation therapy, ROD 2.75 G, SOD 55 G. The treatment was carried out satisfactorily. Currently, there are no signs of a recurrence of the tumor. The use of modern techniques and equipment makes it possible to perform treatment of primary multiple tumors in patients after kidney transplants with satisfactory cosmetic, functional and oncological results.
A CASE REPORT OF AGGRESSIVE SQUAMOUS CELL CARCINOMA IN PATIENTS WITH RECESSIVE DYSTROPHIC EPIDERMOLYSIS BULLOSA
Authors: Kubanov A. , Karamova Arfenya , Chikin Vadim , Monchakovskaya Yekaterina , Nefedova M.
Published: November 2020

Recessive dystrophic epidermolysis bullosa (RDEB) is an orphan genetic skin disease which is caused by mutations in COL7A1 gene. COL7A1 encodes collagen VII - a major component of anchoring fibrils which sustain the dermal-epidermal junction. Non-healing wounds typically are presented in patients with RDEB. They predispose cutaneous squamous cell carcinoma (SCC) development. RDEB-associated SCC is a rapidly growing tumor of aggressive nature which generally arises at young age and results in early mortality. This article reports 2 patients with RDEB-associated SCCs.
DISRUPTED DAILY OSCILLATIONS OF CLOCK GENES EXPRESSION AND CLOCK PROTEINS CONTENT IN TUMORS AND DISTANT TISSUES IN HER2/NEU TRANSGENIC MICE
Authors: Gubareva Ye. , Panchenko A. , Maydin Mikhail , Fedoros Ye. , Tyndyk Margarita , Lnus G. , Anisimov Vladimir , Kireeva Galina
Published: November 2020

The connection between circadian rhythms and cancer is bilateral at the body and cellular level. Negative impact of tumor development on circadian rhythms represents one of its aspects.
Materials and methods. 16 FVB/N and 16 FVB/N transgenic HER2/neu female mice were used in the experiment. 4 mice of each line were euthanized at ZT0 (light switch-on time), ZT6, ZT12 and ZT18. Bmal1, Clock and Cry1 gene expression was evaluated in the suprachiasmatic nucleus, liver, mammary tissue and tumors by real-time PCR. Content of BMAL1 and CLOCK proteins in mammary tissue and tumors was evaluated by immunohistochemistry.
Results. Absence of clock genes expression and clock proteins content daily oscillations was observed in spontaneous mammary adenocarcinomas of HER2/neu transgenic mice. We also revealed decrease in peak values of clock genes expression in the suprachiasmatic nucleus, liver and mammary gland in tumor- bearing animals.
Conclusions. The obtained data confirm the hypothesis about disruption of circadian rhythms in breast tumors and negative influence of tumors on the rhythms of the whole organism.
Plaučių arterinė hipertenzija
Authors: Nargėla Remigijus Valdemaras
Published: November 2020

Straipsnyje supažindinama su šiandienine plaučių arterinės hipertenzijos (PAH) klasifikacija, priimta 2003 m. Venecijoje vykusiame pasauliniame kongrese, šios ligos priežastimis, rizikos veiksniais. Atkreiptas dėmesys į genetinės predispozicijos įtaką PAH, pagrindines PAH priežastis patogenezės požiūriu. Trumpai apžvelgta ligos patogenezė, klinikiniai simptomai, bendrosios gydomosios priemonės: fizinis aktyvumas, infekcijų profilaktika ir kt., įprastinis gydymas antikoaguliantais, diuretikais, deguonimi bei šiuo metu vis dažniau ir sėkmingiau vartojamais prostaciklinais bei jų analogais, endotelino-1 receptorių antagonistais, fosfodiesterazės inhibitoriais.
Pleuros ligų diagnostika
Authors: Zablockis Rolandas
Published: November 2020

Straipsnyje apžvelgiamos dažniausios pleuros ligos, jų priežastys, nagrinėjamos vaizdo tyrimo me-todų, pleuros skysčio, pleuros bioptato tyrimų reikšmė atliekant diferencinę diagnostiką.
Endobronchinio ultragarso tyrimo principai
Authors: Žemaitis Marius , Miliauskas Skaidrius , Stravinskaitė Kristina
Published: November 2020

Endobronchinio ultragarso tyrimas yra naujas ir saugus invazinės pulmonologijos diagnostikos metodas, padedantis gydytojui pulmonologui įvertinti kvėpavimo takų sienelės struktūrą ir ją supančius darinius bei atlikti minimaliai invazines diagnostines procedūras kontroliuojant ultragarsu.
Ikimokyklinio amžiaus vaikų bronchų obstrukcijos klinikinio įvertinimo, diagnostikos ir gydymo galimybės
Authors: Skurvydienė Iveta
Published: November 2020

Bronchų obstrukcijos diagnostikos ir gydymo galimybės analizuojamos vadovaujantis Europos respiratologų draugijos ekspertų grupės parengtomis rekomendacijos ikimokyklinio amžiaus vaikų švokštimui įvertinti, diagnozuoti ir gydyti. Straipsnio pabaigoje aprašomas klinikinis sunkios ir blogai kontroliuojamos astmos atvejis.
Atopinis dermatitas
Authors: Ėmužytė Regina
Published: November 2020

Atopinis dermatitas (egzema) yra lėtinė odos uždegimo liga, sukelianti stiprų niežulį ir dažniausiai prasidedanti kūdikystėje ar ankstyvoje vaikystėje. Ja serga 10–20 proc. pasaulio vaikų. Nuo jos nukenčia tiek vaikų, tiek jų tėvų gyvenimo kokybė. Atopinio dermatito patogenezės ir naujų gydymo alternatyvų sampratos evoliucija yra naudinga siekiant pagerinti šios ligos ilgalaikę kontrolę. Straipsnyje apžvelgiama nauja atopinio dermatito (egzemos) terminija ir diagnostikos duomenys. Pateikiamos naudingos gydymo rekomendacijos, paremtos ligos sunkumo laipsniu, pabrėžiant profilaktikos, emolientų vartojimo ir gydymo naujais vietinio poveikio vaistais nuo alerginio uždegimo – kalcineurino inhibitoriais – reikšmę.
Naujausios žinios apie alerginį rinitą ir jo įtaką astmai
Authors: Staikūnienė Jūratė
Published: November 2020

Alerginis rinitas (AR) – dažna lėtinė kvėpavimo takų liga, bloginanti gyvenimo kokybę, darbingumą ir ekonomiškai nuostolinga. AR dažnai susijęs su konjunktyvitu, sinusitu ir yra astmos rizikos veiksnys. 1999 metais Pasaulinė sveikatos organizacija įkūrė alerginio rinito ir jo įtakos astmai darbo grupę (ARIA), kuri 2008 metais paskelbė naujausias žinias apie šios ligos gydymą bei įtaką astmai. Dokumente pateikiama alerginio rinito klasifikacija, pagal kurią ši liga gali būti epizodinė ir nuolatinė. Pagal simptomų pobūdį ir intensyvumą AR gali būti lengvos ir vidutinio sunkumo/sunkios eigos. Alerginio rinito gydymas yra pakopinis, jis priklauso nuo ligos sunkumo ir susideda iš pagrindinių etapų: ligą sukeliančio alergeno vengimo, medikamentinio gydymo, imunoterapijos, pacientų mokymo. Sergantieji nuolatiniu AR turi būti ištirti dėl astmos, o sergantieji astma turi būti ištirti dėl alerginio rinito, esant viršutinių ir apatinių kvėpavimo takų pažeidimo požymių, turi būti taikomas sudėtinis alerginio rinito ir astmos gydymas.
Lėtinė autoimuninė dilgėlinė: mechanizmai ir nustatymo metodai
Authors: Chomičienė Anželika , Blažienė Audra
Published: November 2020

Didelė dalis lėtinės dilgėlinės atvejų siejami su autoimunine kilme, nes randama funkcinių antikūnų prieš didelio giminingumo (afiniteto) imunoglobulino E receptorius arba prieš patį imunoglobuliną E. Šie antikūnai sukelia histamino atsipalaidavimą iš bazofilų ir odos putliųjų ląstelių. Autoantikūnai pacientų kraujyje nustatomi įodiniu odos mėginiu su autologiniu serumu ir jų buvimas patvirtinamas in vitro laboratoriniu histamino atsipalaidavimo iš donoro bazofilų mėginiu. Pastaruoju metu pradėti taikyti bazofilų aktyvacijos tyrimai.
Alternatyvūs dilgėlinės gydymo metodai
Authors: Slomskis Tomas , Šitkauskienė Brigita
Published: November 2020

Straipsnyje apžvelgiami naujausi mokslo literatūroje aprašomi atsparios tradiciniam gydymui dilgėlinės alternatyvūssėkmingo gydymo metodai.
Šiandienos žvilgsnis į tuberkuliozę
Authors: Butkuvienė Vida
Published: November 2020

1882 m. didysis vokiečių gydytojas R. Kochas atrado tuberkuliozės sukėlėją. Diagnozuojant ir gydant tuberkuliozę žmonija nuėjo ilgą ir sudėtingą kelią. 1944 m. atrastas pirmas vaistas nuo tuberkuliozės – streptomicinas. 1993 m. PSO tuberkuliozę paskelbė pasauline problema, tuberkuliozės kontrolę – prioritetine veikla, tiesiogiai kontroliuojamo gydymo strategiją – viena efektyviausių tuberkuliozės kontrolės priemonių. Nereguliarus vaistų vartojimas, gydymo nutraukimas sudarė prielaidas atsirasti vaistams nuo tuberkuliozės atsparioms tuberkuliozės mikobakterijoms (TM). Siekiant sumažinti atsparios tuberkuliozės plitimą, itin aktualėja atsparios tuberkuliozės strategija ir tinkamas gydymas.
Bronchų astma: teorija ir praktika
Authors: Barkauskienė Diana
Published: November 2020

Gydant astmą siekiama ne tik apsaugoti pacientą nuo astmos paūmėjimų, bet ir sudaryti sąlygas gyventi visavertį gyvenimą kontroliuojant ligą. Vaistus astmai gydyti galima skirti į dvi grupes: simptominius ir kontroliuojamuosius. Pirmieji yra beta 2 agonistai, šalinantys ar lengvinantys ligos simptomus, o antrieji – gliukokortikosteroidai, vartojami nuolatos, kad nepasireikštų astmos simptomų. Inhaliuojamieji gliukokortikosteroidai dažnai derinami su ilgai veikiančiu beta 2 agonistu (IVBA).
SPIRIVA® Respimat® – naujas LOPL inhaliacinis gydymas
Authors: Sakalauskas Raimundas
Published: November 2020

NAUJIENAFarmacijos kompanija „Boehringer Ingelheim“ sukūrė unikalų inhaliatorių Respimat®, kuriame ypatingas išpurškimo mechanizmas sukuria lėtai judantį drėgną vaisto srautą (vadinamąjį Soft Mist), kurį pacientui yra lengva ir paprasta įkvėpti į plaučius.
Astmos ir eozinofilinio bronchito sukeltas kosulys
Authors: Dičpinigaitis Petras V.
Published: November 2020

Kosulys yra vienas dažniausių simptomų, dėl kurio žmonės kreipiasi į gydytoją. Astma ir eozinofilinis bronchitas – viena dažniausių lėtinio kosulio priežasčių. Straipsnyje aptariamos kosulio astmos ir eozinofilinio bronchito sukelto lėtinio kosulio diagnostikos ir gydymo problemos.
Kosulys ir rūkymas
Authors: Stravinskaitė Kristina
Published: November 2020

Kosulys – svarbus kvėpavimo sistemos apsauginis refleksas. Kosuliu skundžiasi 9–33 proc. Europos ir JAV gyventojų. Kosulys yra vienas dažniausių simptomų, dėl kurių pacientai kreipiasi į gydytoją. Vaistams nuo kosulio, nepaisant jų dalinio efektyvumo, išleidžiama šimtai milijardų dolerių. Taigi kosulio problema aktuali ne tik medicininiu, bet ir socialiniu bei ekonominiu požiūriu. Rūkymas yra vienas svarbiausių išvengiamų kvėpavimo ligų rizikos veiksnių. Rūkymas sumažina sveikų asmenų kosulio reflekso jautrumą, bet jis normalizuojasi jiems metus rūkyti. Sergančių LOPL rūkorių ir sergančių LOPL buvusių rūkorių kosulio reflekso jautrumas nesiskiria.
Kosulys otorinolaringologo požiūriu
Authors: Pribuišienė Rūta , Ulozas Virgilijus
Published: November 2020

Nustatant kosulio priežastį neretai bendradarbiauja kelių specialybių gydytojai. Kadangi kosulį gali provokuoti viršutiniuose kvėpavimo takuose (ryklėje, gerklose) esančių refeksinių sričių dirginimas, svarbu otorinolaringologinis paciento tyrimas. Otorinolaringologai gali patvirtinti ar atmesti daugelį kosulio priežasčių: gastroezofaginio refliukso ligos laringofaringinę formą, gerklų darinius, svetimkūnius ar balso klosčių paralyžių, nosies ir prienosinių ančių bei išorinės klausomosios landos ligas. Tik kompleksinis priežastinis gydymas garantuoja laukiamą stabilų gydymo efektą.
Veiksniai, turintys įtakos sveikų žmonių kvėpavimui miegant
Authors: Januškevičiūtė Asta
Published: November 2020

Miegas – periodiška sąlyginė ramybės būsena, kurios metu organizmas aktyviai atkuria jėgas. Kai žmogus miega, susilpnėja jo fiziologinės funkcijos, jis nemato ir negirdi, išnyksta sąmoningas psichikos aktyvumas. Miego metu keičiasi ir kvėpavimas. Straipsnyje nagrinėjami veiksniai, kurie turi įtakos miegančių sveikų žmonių kvėpavimui. Tyrimai rodo, jog amžius ir cheminės medžiagos bei vaistai, kaip antai alkoholis bei benzodiazepinai, slopina kvėpavimą, sumažina deguonies įsotinimą kraujyje, tuo tarpu lytis neturi ryškesnės įtakos kvėpavimui.
Lėtine obstrukcine plaučių liga serganičių ligonių reabilitacija
Authors: Kryžiūtė Dovilė , Vedrickaitė Jolita
Published: November 2020

Pagrindiniai plaučių ligų reabilitacijos tikslai yra lengvinti simptomus, gerinti paciento gyvenimo kokybę ir skatinti fizinį bei emocinį aktyvumą. Sprendžiamos ir kitos problemos: fizinio krūvio toleravimo mažėjimo, santykinės socialinės izoliacijos, nuotaikos sutrikimų, ypač depresijos, raumenų nykimo ir kūno masės mažėjimo. Didžiąją dalį pacientų, kuriems skiriama pulmonologinė reabilitacija, sudaro ligoniai, sergantys lėtine obstrukcine plaučių liga (LOPL). Straipsnyje apžvelgiamos naujausios Amerikos torakalistų bei Europos pulmonologų sąjungos parengtos pulmonologinės reabilitacijos rekomendacijos.
Vietinių anestetikų šalutinis poveikis - alergija ar kitas nepageidaujamas poveikis
Authors: Ragaišienė Sandra , Šitkauskienė Brigita
Published: November 2020

Straipsnyje aptartas galimas vietinių anestetikų nepageidaujamas poveikis, kurį sunku atskirti nuo tikrosiosalergijos. Vietinio anestetiko sukeltus simptomus reikėtų laikyti vaisto nepageidaujamu toksiniu poveikiu. Kartu reikiaįvertinti kitas galimas priežastis: paciento susijaudinimą, hiperventiliaciją, klajoklio nervo ir kraujagyslines reakcijas beiadrenalino, esančio kai kurių vietinių anestetikų tirpaluose, poveikį. Taip pat svarbu įsitikinti, ar pacientas nėra įsijautrinęslateksui. Tikrąsias alergines reakcijas anestetikai sukelia labai retai – jos tesudaro 1 proc. visų nepageidaujamų šiųvaistų reakcijų. Gydytojams svarbu atskirti tikrosios alergijos ir kito nepageidaujamo poveikio simptomus ir skirti tinkamągydymą. Pacientą, kuriam įtariama buvusi alerginė reakcija vietiniam anestetikui, reikėtų siųsti pas alergologą. Alergijaipatvirtinti paprastai atliekami odos ir didėjančių dozių provokaciniai mėginiai. Straipsnyje pateiktos alerginių reakcijų įvietinius anestetikus gydymo rekomendacijos.
Symbicort SMART - pažangus metodas siekti astmos kontrolės
Authors: Šitkauskienė Brigita
Published: November 2020

Pagrindinis astmos gydymo tikslas, t. y. astmos kontrolė, pasiekiamas gerinant klinikinių ligos simptomų valdymą ir kartu mažinant paūmėjimų riziką. Klinikinių tyrimų duomenys rodo, kad taikant palaikomąjį ir simptomus slopinantį gydymą vienu inhaliatoriumi – budezonido ir formoterolio deriniu (Symbicort SMART) – suaugusiems pacientams, sergantiems vidutinio sunkumo ar sunkia astma, pavyksta geriau kontroliuoti ligą nei gydant įprastiniu būdu: vien inhaliuojamaisiais gliukokortikosteroidais arba inhaliuojamaisiais gliukokortikosteroidais ir ilgai veikiančių beta 2 agonistų fiksuota doze, o simptomus slopinant trumpai veikiančiais beta 2 agonistais.
UPLIFT - ilgalaikių lėtinės obstrukcinės plaučių ligos gydymo tyrimų gairės
Authors: Sakalauskas Raimundas
Published: November 2020

2008 m. spalio 5 d. Berlyne vykusiame Europos respiratologų draugijos (ERS) kasmetiniame kongrese buvo viešai paskelbti UPLIFT® (angl. Understanding Potential Long-term Impacts on Function with Tiotropium) tyrimo rezultatai. UPLIFT®, viename didžiausių kada nors atliktų lėtinės obstrukcinės plaučių ligos (LOPL) tyrimų, dalyvavo 5 993 LOPL sergantys pacientai iš 490 tyrimo centrų 37 pasaulio šalyse, įskaitant Lietuvą. Tyrimui vadovavo profesorius Marc Decramer, Belgijos Liuveno (Leuven) mieste esančio Katalikų universiteto ligoninės Pulmonologijos skyriaus vadovas.
«Crítica literaria y configuración genérica de las ‘Historias caballerescas breves’»
Authors: Luna Mariscal Karla Xiomara
Published: November 2020

Resumen: Se analiza el papel que el motivo literario ha tenido en algunas de las propuestas críticas en torno a la configuración genérica de las Historias caballerescas breves. Un estudio de la historia crítica de su agrupación genérica permite un mejor acercamiento a su comprensión como ‘modelo narrativo’. El objetivo no es proponer una nueva clasificación, sino partir de la revisión de las propuestas ya hechas para clarificar las relaciones entre las obras.Palabras clave: Motivo. Género. Historias-caballerescas. Breves.Abstract: Analysis of the role that the literary motif has in some theoretic proposal on Genres’ configuration in Short Chivalric Romances. A study of the critical history of generic group allows a better approach to its understanding as ‘narrative model’. The aim isn’t propose a new classification, but to depart from the review of the proposals already done to clarify the relations between the works.Keywords: Motif. Theoretic. Genres. Chivalric romances.
«Invocar, validar, perpetuar (un círculo de círculos)»
Authors: Suárez González Ana
Published: November 2020

Resumen: En el interior de la catedral de Santiago de Compostela doce cruces de piedra rodeadas por inscripciones recuerdan la consagración de la iglesia que tuvo lugar 21 de abril de 1211 por ministerio del arzobispo Pedro Muñiz. Son doce signos de signos circulares a la vez rituales y validatorios. La mirada se traslada del templo al archivo, del recuerdo en piedra de la catedral compostelana a la memoria en pergamino de dos cartularios de la abadía cisterciense de Santa María de Sobrado (AHN, Códice 976) y la canónica de San Juan de Caaveiro (AHN, Códice 1439) para poner en valor otros signos de signos circulares, provistos asimismo de cruces y letreros, singulares y sorprendentes. También en estos manuscritos rito litúrgico y requisito diplomático se mezclan para invocar, validar y perpetuar mensajes, conduciéndonos así, de cruz a cruz, en un círculo de círculos, al punto de partida.Palabras clave: Carmen figuratum. Cartularios. Catedral de Santiago. Cruces de consagración. Liturgia. Pedro Muñiz. Signos rodados. Abstract: Twelve consecration crosses surrounded by inscriptions commemorate the consecration of Santiago cathedral officiated by Pedro Muñiz in April, 21, 1211. They six round signs of signs echo the ritual but they also validate it. For that reason it is possible to move our gaze from the temple to the archive, from the stone commemoration to the memories preserved in two cartularies –the one from the Cistercian Abbey of Santa María de Sobrado (AHN, Códice 976) and another from the priory of San Juan de Caaveiro (AHN, Códice 1439)– in order to discover other circular, intriguing signs of signs, provided with crosses and inscriptions as well. In these manuscripts liturgical ritual and diplomatic requirement mix up to invocate, validate and perpetuate the messages, leading us from cross to cross, in a circle of circles, to the point of departure.Keywords: Carmen figuratum. Cartularies. Santiago Cathedral. Consecration crosses. Liturgy. Pedro Muñiz. Rotae.
Sobre la presencia y ausencia de la -e paragógica en los romances carolingios impresos durante el período postincunable
Authors: Mahiques Climent Joan
Published: November 2020

En este artículo se establece un corpus de once romances carolingios documentados a través de pliegos poéticos postincunables que desarrollan el recurso de la -e paragógica aplicada sobre la rima aguda en -á. Los datos más relevantes de cada uno de los once romances quedan reflejados en varias tablas ubicadas al final del artículo y referidas tanto a las rimas utilizadas como a las características de algunos de sus testimonios impresos en el siglo XVI. Concretamente, se ha procedido a registrar los pliegos sueltos poéticos conservados íntegramente en bibliotecas de acceso público más los testimonios incluidos en el Cancionero de Romances sin año, pero impreso en 1546 o 1547, o en las partes segunda y tercera de la Silva de varios romances de Esteban G. de Nájera (1550-1551). El análisis combinado de las rimas de los romances y de los datos tipográficos de sus testimonios (lugar de edición, impresor y fecha) permite establecer una serie de tendencias en el uso de la -e paragógica desde la etapa postincunable hasta el final del siglo xvi. Destaca, por ejemplo, el rechazo sistemático de la -e paragógica en los pliegos poéticos postincunables impresos en Sevilla por Jacobo Cromberger. Las ediciones burgalesas anteriores al Cancionero de romances siguen en unas ocasiones la práctica de Jacobo Cromberger, mientras que en otras incorporan la -e paragógica con suma regularidad. Durante la segunda mitad del siglo, cancioneros impresos y pliegos poéticos ejercieron una influencia mutua y en ambos sentidos.
Sendebar. Libro de los engaños e los asayamientos de las mugeres, ed. de David Arbesú, Newark, Juan de la Cuesta Hispanic Monographs, 2019. 152 pp. ISBN: 978-1-58871-339-1 (HB); 978-1-58871-340-7 (PB).
Authors: Aranda García Nuria
Published: November 2020

Se presenta una reseña de la reciente edición del Sendebar propuesta por el medievalista David Arbesú. La novedad de su propuesta, tal y como se recoge en en las páginas que siguen, radica en la profunda reflexión que se ha realizado sobre el texto y sus lagunas, con el objetivo de arrojar algo de luz sobre las incongruencias de parte de su contenido narrativo.
La prueba pericial como elemento probatorio en el proceso penal acusatorio de la República de Panamá
Authors: Barría Vargas Guillermo
Published: November 2020

El medio de prueba pericial, antes era poco conocido o difundido; sin embargo, con los avances tecnológicos y las nuevas tendencias o campos en las cuales se desarrollan las relaciones personales, comerciales y jurídicas, han llevado a fortalecer su uso y se ha incorporado como el resto de la evidencia, siendo un medio de prueba más contundente, preciso y eficaz, logrando instruir en buena medida a los jueces de elementos que estos desconocen, aunque el tribunal tiene la facultad de apartarse del criterio expuesto en el dictamen pericial, siempre y cuando pueda fundamentar correctamente el punto de vista propio. En la actualidad, el perito dentro del Sistema Penal Acusatorio, es un medio de prueba imprescindible para la adecuada fundamentación de las alegaciones de los litigantes y la correcta resolución por parte del Juez.
Tendencias en derecho penal: Un enfoque global versus la realidad panameña
Authors: González Herrera Alberto H.
Published: November 2020

El Derecho penal en la República de Panamá,  siguiendo las tendencias en el Derecho Internacional y Comparado ha sufrido modificaciones, ha tenido presente la necesidad de reconocer desde los delitos en el ámbito informático, los que tratan de salvaguardar a las personas que migran lícita o ilícitamente de su país en búsqueda de mejores condiciones de vida hasta afinar las restricciones a los capitales que generan riqueza a empresas y personas. El tema a desarrollar es un tema amplio que trataremos de delimitar a efectos de ser claro, conciso y preciso como debe ser un libelo de casación o de anulación propuesto contra la sentencia penal. Se denomina Tendencias en Derecho Penal: un enfoque global versus la realidad panameña. Algo así como un análisis comparativo de lo que acaece en el mundo frente a lo que pasa en nuestro país en materia penal.
Las pruebas en el proceso penal y su valoración por el juez
Authors: González Deika
Published: November 2020

Dentro del proceso penal, la pericia se practica desde la averiguación previa, ya que de ella se vale el Ministerio Publico para determinada la existencia del cuerpo del delito y la presunta responsabilidad del inculpado. Esto ocurre cuando determinados hechos o circunstancias no pueden apreciarse de forma debida si no es a través de la intervención de algún perito en la materia sobre el cual versen dudas de carácter técnico.
Los acuerdos solución como formas alternas de del conflicto penal
Authors: Espada María
Published: November 2020

El sistema PenalAcusatorio trae a nuestro sistema jurídico positivo, una serie de herramientas y mecanismos, que otrora eran impensables en el Derecho Penal patrio. Los acuerdos son realmente herramientas que no solo buscan llenarel principio de economía procesal, sino que resultan sendos mecanismos para determinar la responsabilidad de los incriminados y sobre todo, la certeza de la verdad material por medio del reconocimiento de las actuaciones ilícitas cometidas por estos:
Juridicidad de las actuaciones de liquidadores dentro del régimen cooperativo de Panamá
Authors: Osellame Rosillo Gino , Fong Buckridge Jaime
Published: November 2020

Cuando una cooperativa está en liquidación, es necesario tener claro que se trata un proceso, cuyo objetivo se focaliza en ajustar las cuentas de dicha persona jurídica en estado de insolvencia, de tal manera que se determine lo que corresponda a los interesados, según sus derechos activos y pasivos. Por regla general, descansa en la figura jurídica del liquidador, el rol de llevar a cabo dicho proceso, y por tanto, es quien debe en resumidas cuentas inventariar, cobrar y pagar a quienes corresponda según su derecho. Si bien, las tres funciones básicas del liquidador (inventariar, cobrar y pagar), no resulta en la práctica, una actividad de somera ejecución. Se trata más bien, de ejercer funciones propias de cualquier administrador, con la diferencia que el liquidador, sólo tiene una masa de activos, para equilibrar pasivos, sin activar la operación original del fallido. En este sentido, el ejercicio de las funciones del liquidador está enmarcadas en instituciones jurídicas definidas como el mandato especial (Derecho Civil) y buenas prácticas de administración general, tal como lo expone de forma prístina el artículo 90 de la Ley 17 de 1 de mayo de 1997, a propósito de la representación legal de la comisión liquidadora, y su relación con la cooperativa.
Clima organizacional en las instituciones educativas de Santa Marta, Colombia
Authors: Hincapié Parejo, Nair Farides , Orellana Orellana, Edison Fernando , Corellanao@ucacue.edu.ec Carlos
Published: November 2020

El objetivo del artículo es determinar el clima organizacional en las instituciones escolares de Santa Marta Colombia, bajo los fundamentos teóricos de autores, tales como: Brunet (2008), Robbins y Coulter (2010), Chiavenato, (2006), Daft y Marcic, (2006), Goncalves (2007) entre otros. La investigación fue descriptiva con diseño de campo, transeccional y no experimental. La población estuvo conformada por seis unidades educativas públicas básicas primaria ubicadas en la ciudad de Santa Marta. Las unidades informantes fueron 6 rectores y 83 docentes. Se diseñaron dos instrumentos de recolección de datos, tipo escala tipo Lickert. Los instrumentos fueron sometidos a validez y confiabilidad a través del método Alfa de Cronbach obteniéndose una confiabilidad para el instrumento dirigido a los rectores de 0,964 y 0,902 para los docentes. La alternativa algunas veces exhibe el mayor porcentaje para el grupo de rectores; mientras que para los docentes la mayor cantidad de respuestas estuvo orientada hacia la alternativa casi siempre. Se puntualiza que el clima organizacional se ubicó en un rango medianamente apropiado, pero en el extremo inferior (3.62).
Using multiple self-sorting for switching functions in discrete multicomponent systems
Authors: Ghosh Amit , Schmittel Michael
Published: November 2020

Over years self-sorting has developed into a powerful tool in supramolecular chemistry, for instance, to promote the error-free formation of intricate multicomponent assemblies. However, in order to use the enormous potential of self-sorting for sophisticated information processing more recent developments have focused on the reversible reconfiguration of multicomponent systems driven by multiple self-sorting protocols. The present mini review will provide an overview over the latest advancements in this field with a focus on reversibly switchable functions in discrete supramolecular systems.
Faktor-Faktor Yang Berpengaruh Terhadap Keputusan Pembelian Konsumen Toko Ramona Palembang
Authors: Djamin Zulkifli
Published: November 2020

Dewasa ini Retail atau Minimarket semakin banyak dibuka di berbagai tempat baik di kota besar maupun di kota kecil, termasuk di kota Palembang. Kehadiran pasar swalayan dan minimarket merupakan tuntutan perubahan gaya hidup masyarakat kota. Persaingan yang semakin ketat di mana semakin banyak produsen yang terlibat dalam pemenuhan kebutuhan dan keinginan konsumen, menyebabkan setiap perusahaan harus menempatkan orientasi pada kepuasan konsumen sebagai tujuan utama. Tujuan penelitian adalah (1) Untuk mengetahui adanya pengaruh dari faktor produk, pelayanan, dan lokasi terhadap keputusan pembelian konsumen pada Toko Ramona Palembang, (2) Untuk mengetahui seberapa besar pengaruh dari faktor produk, pelayanan, dan lokasi terhadap keputusan pembelian konsumen pada Toko Ramona Palembang. (3) Untuk mengetahui faktor manakah diantara faktor produk, pelayanan, dan lokasi yang memberikan pengaruh terbesar terhadap keputusan pembelian konsumen pada Toko Ramona Palembang.
The Repercussions of Covid-19 On the field of education
Authors: Naji Abdennasser
Published: November 2020

Morocco was one of the first countries to take a set of precautionary measures aimed at curbing the spread of the virus, especially when it was found that all the cases discovered were from abroad. The goal was not to allow the virus to infect residents of the homeland by closing the air, land and sea borders. This contributed to reducing the number of local cases, without permanently canceling the occurrence of this matter.
In line with the same proactive policy adopted by the state, several measures have been taken aimed at implementing the principle of social separation, which was mainly manifested in the application of lock-down to citizens. The school, which is attended by about a third of Moroccan citizens, has been closed since March 16, 2020, for fear that it will constitute hotbeds of the virus that are difficult to control. Given that schools represent spaces for heavy gathering for children and adults alike, this may provide an appropriate environment for the spread of Covid-19 in the school population.
The Role of Using Information Communication Technology in the Motivation of Moroccan English Department Students during COVID-19 Quarantine
Authors: Benhima Mohamed , Benabderrazik Youssef
Published: November 2020

The current study aims to investigate the role of using Information Communication Technology in motivating Moroccan English Department Students to learn during COVID-19 quarantine that lasted from the mid of March to the mid of July. Distance education or emergency remote instruction has become the standard way of teaching and learning during COVID-19. Hence, many universities have started uploading their lesson materials to different platforms. However, many students feel unmotivated to learn using ICT. To prove this hypothesis, a questionnaire in Google Forms was submitted to 114 students from some Moroccan English Department students to investigate the motivating and demotivating factors behind using ICT. Both open and closed-ended questions were used. Moreover, a focus group on the topic of motivation during distance education was conducted for more in-depth data. The results revealed that the most highly motivating factor behind using ICT to learn is attributed to extrinsic factors, whereas the demotivating factors are about lack and weakness of connection and lack of orientation. It is highly recommended that educational administrators and authorities respond to students’ needs.
In vitro Cytotoxicity Studies of Industrially Used Common Nanomaterials on L929 and 3T3 Fibroblast Cells
Authors: Srikanth M , Khan WS , Asmatulu R , Misak HE , Yang SY , Asmatulu E
Published: November 2020

The unique structures and properties of nanomaterials have attracted many engineers and scientists to these resources for different applications, including biomedical, electronics, manufacturing, transportation, energy, and defense. The increasing applications of nanomaterials have also caused some concern among the scientific community about their safety and cytotoxicity. To successfully use nanomaterials in different fields, their interaction with mammalian cells in vitro must be addressed before in vivo experiments can be carried out successfully. In this study, the cytotoxicity values of commonly known nanomaterials, such as 100-ply Carbon Nanotube (CNT) wires, graphene, CNTs, nanoclay, and fullerene, were investigated through in vitro tests on human L929 and mice 3T3 fibroblast cells and compared with each other. The effects of cytotoxicity on both cell types were similar in many ways, but not closely identical due to structural and morphological differences. Compared to mice fibroblast cells, human fibroblast cells have a larger surface area; therefore, the viability values of L929 cells at different dilutions and time durations vary over a larger range. Pristine 100-ply CNT wires were found to be the least cytotoxic, with an average viability of 86.9%, whereas materials with high aspect ratio (e.g., CNTs and graphene) had higher cytotoxicity values due to their potential to pierce through cell membranes.
Diagnosing Fetal Skeletal Dysplasia Using Three-Dimensional Computed Tomography: A Study Protocol for an Interventional Study
Authors: Waratani M , Ito F , Tanaka Y , Aki M , Mori T , Kitawaki J
Published: November 2020

Background: Fetal skeletal dysplasias are a group of skeletal dysplasias occurring during the fetal stage. As the use of fetal ultrasonography has become widespread, the rate of prenatal diagnosis of skeletal dysplasias has increased. However, many fetal skeletal dysplasia phenotypes have indistinct definitions, making definitive prenatal diagnosis difficult. Fetal imaging methods that are the basis of diagnosing fetal skeletal dysplasias include ultrasonography and three-dimensional computed tomography. The use of three-dimensional computed tomography requires specific imaging techniques and cannot easily be performed at all facilities. In the present study, we propose to conduct a survey for the preparation of a protocol with a low risk, and a high diagnostic accuracy. Methods: In total, 50 pregnant women who undergo three-dimensional computed tomography for the diagnosis of fetal skeletal dysplasias will be included. The primary outcome is prenatal diagnostic accuracy for fetuses with skeletal dysplasias. The secondary outcome is the safety from radiation exposure. Results and conclusion: Three-dimensional computed tomography should be considered for the prenatal diagnosis of fetal skeletal dysplasias, as it is important to judge whether the prognosis is favorable or lethal. When considering the risk of radiation exposure, high quality images that are adequate for a diagnosis have been obtained using low-dose three-dimensional computed tomography scans. This approach reduces the level of radiation to which the pregnant woman and fetus are exposed.   Trial registration: University hospital Medical Information Network (UMIN) Center: Trial registration number is UMIN000034744. Data of registration is October 01, 2018. (URL: https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000039610)
Is Fault Detection and Diagnosis in Pneumatic Actuator A Topic of Concern?
Authors: Navada Bhagya R , Santhosh K. V
Published: November 2020

The present civilization highly depends on industrial products and hence there is an increased demand for the same. Therefore, each industry is trying to increase its production output without hindering the quality. Maintenance of plant health is essential to improve the production rate without any loss. Industrial processes require monitoring of every element as their consistent behavior is a fundamental concern. Any deviation in the working of these components may alter the quality of the end product, causing a huge loss for the industry. Therefore, monitoring and finding the root cause for irregular behavior of industrial processes is a requisite for avoiding any future loss. In this paper, an attempt is made to present types of faults, types of pneumatic actuator faults, and different techniques used for the detection and isolation of faults. Simulation work is carried out to generate stiction behavior in the control valve using the Choudhury stiction model. Valve stiction behavior for different values of stick band and jump values are discussed in this paper. A comparison of several techniques used for the detection of faults based on two performance indices namely true detection rate and false alarm rate has been given at the end of this paper. From these techniques, it is observed that these indices are interdependent, such that an increase in the detection rate increases the false detection rate and increases detection time.
Numerical Study of Turbulent Flows and Convective Heat Transfer of Al2O3-Water Nanofluids In A Circular Tube
Authors: Mahammedi Abdelkader , Ameur Houari , Menni Younes , Medjahed Driss Meddah
Published: November 2020

The convective heat transfer of Al2O3-water nanofluids through a circular tube with a constant heat flux boundary condition is studied numerically. Turbulent flow conditions are considered with a Reynolds number ranging from 3500 to 20000. The numerical method used is based on the single-phase model. Four volume concentrations of Al2O3-water nanoparticles (0.1, 0.5, 1, and 2%) are used with a diameter of nanoparticle of 40 nm. A considerable increase in Nusselt number, axial velocity, and turbulent kinetic energy was found with increasing Reynolds number and volume fractions. However, the pressure losses were also increased with the raise of Re and nanoparticles concentration.
Thermoacoustic Energy Conversion Devices: Novel Insights
Authors: A. Alamir Mahmoud
Published: November 2020

Thermoacoustic engines and refrigerators have many advantages. They use environment-friendly working gases, their design is simple, and they can operate quietly. However, they have many design characteristics from geometric parameters and operating conditions. Besides this, they still have low efficiencies and performance. This paper summarises important considerations of the design and presents the state-of-the-art developments in thermoacoustic energy conversion devices. This includes recent studies and designs of the thermoacoustic refrigeration devices towards more efficient thermoacoustic engines and refrigerators. New insights into the design of resonators, the different sources of the power sources, the different stack geometries and working mediums were considered. The challenges that face the development of thermoacoustic devices were also discussed. Far too little attention has been paid to looking at these devices comprehensively. In further research, the use of neural networks and metadata as optimisation methods could be a means of significantly increasing the performance of these devices. There is also abundant room for further progress in enhancing oscillatory heat transfer. Moreover, further recommendations and studies were proposed for a better understanding of the interrelationship between the geometric parameters and operating conditions.
Investigate the Drag Resistance of Antifouling Self-Adhesive Film
Authors: Wei-Hann Khor , Chee Loon Siow , Abdul Malik Adi Maimun , Ali Arifah , Jainal Mohammad Nabil , Yong Chung Ee Jonathan
Published: November 2020

Fouling has always been a common issue for ships as fouling drastically increases the surface roughness and ship resistance. The microfiber self-adhesive antifouling film is claimed to be effective up to 5 years and is environmentally friendly. However, there is lack of information about the drag characteristics of the antifouling material. Thus, this project is conducted based on an experimental study to determine the drag characteristics of the surface installed with microfiber self-adhesive antifouling film. The rotor apparatus is used to study the coefficient of friction of the microfiber surface. From the experimental results, a flat plate simulation using ANSYS-Fluent is conducted to further estimate the coefficient of friction up to Reynolds number of 109 and to evaluate the total ship resistance for the Semi-SWATH (fast vessel) and KVLCC (slow trading ships). The results show that the percentage increase in total ship resistance for the KVLCC is about 80%, which is more than the Semi-SWATH of 30%, as frictional resistance has high significance for slow trading ships. The speed drop experienced by the ship model installed with the microfiber antifouling is 2 knots for the KVLCC and 1 knot for the Semi-SWATH if the power remained the same for both models.