bluuebunny/crossref_metadata_2025 huggingface dataset:
Proposal of real estate mass valuation in Slovenia based on generalised additive modelling approach
Authors: Ulbl Melita , Verbič Miroslav , Lisec Anka , Pahor Marko
Published: April 2021

The present paper discusses the heterogeneity of the apartment market. For this purpose, we have developed the model for the mass valuation of apartments in the Republic of Slovenia. The construction of the mass valuation model is based on the generalised additive model approach. In this paper, the development of the model is presented. In the experimental part, the analysis of the results of the two models is performed. The dependent variable (the price of an apartment) is distributed according to the Gaussian and the gamma distributions. Particular attention has been paid to the impact of the transaction time on the apartments’ transaction value. The results of the model are also compared with the results of the mass valuation model in the Republic of Slovenia, which is carried out cyclically and iteratively, the results of which depend on the results (and mass valuation models) of previous cycles.
What have we learnt from ICESat on greenland ice sheet change and what to expect from current ICESat-2
Authors: Bukač Blaženka , Grgić Marijan , Bašić Tomislav
Published: April 2021

Ice-sheet mass balance and ice behaviour have been effectively monitored remotely by space-borne laser ranging technology, i.e. satellite laser altimetry, and/or satellite gravimetry. ICESat mission launched in 2003 has pioneered laser altimetry providing a large amount of elevation data related to ice sheet change with high spatial and temporal resolution. ICESat-2, the successor to the ICESat mission, was launched in 2018, continuing the legacy of its predecessor. This paper presents an overview of the satellite laser altimetry and a review of Greenland ice sheet change estimated from ICESat data and compared against estimates derived from satellite gravimetry, i.e. changes of the Earth’s gravity field obtained from the GRACE data. In addition to that, it provides an insight into the characteristics and possibilities of ice sheet monitoring with renewed mission ICESat-2, which was compared against ICESat for the examination of ice height changes on the Jakobshavn glacier. ICESat comparison (2004–2008) shows that an average elevation change in different areas on Greenland varies up to ±0.60 m yr−1. Island’s coastal southern regions are most affected by ice loss, while inland areas record near-balance state. In the same period, gravity anomaly measurements showed negative annual mass balance trends in coastal regions ranging from a few cm up to -0.36 m yr-1 w.e. (water equivalent), while inland records show slightly positive trends. According to GRACE observations, in the following years (2009–2017), negative annual mass balance trends on the coast continued.
Long noncoding RNA DLEU2 drives the malignant behaviors of thyroid cancer through mediating the miR-205-5p/TNFAIP8 axis
Authors: Yang Jiwen , Huang Yayin , Dong Bohan , Dai Yunhai
Published: April 2021

Objective

Considering the plight in thyroid cancer therapy, we aimed to find novel therapeutic targets from a molecular perspective.

Methods

Quantitative real-time PCR (qRT-PCR) and Western blot assay were carried out to determine RNA and protein expression. Cell counting kit-8 (CCK8) assay, flow cytometry, transwell migration assay and aerobic glycolysis analysis were performed to analyze cell proliferation, apoptosis, migration and aerobic glycolysis of thyroid cancer cells. MiRcode and Starbase software were used to search the downstream genes of long noncoding RNA (lncRNA) deleted in lymphocytic leukemia 2 (DLEU2) and microRNA-205-5p (miR-205-5p), and the intermolecular combination was confirmed by dual-luciferase reporter assay. The in vivo role of DLEU2 in tumor growth was verified using the murine xenograft model.

Results

DLEU2 and tumor necrosis factor-α-induced protein 8 (TNFAIP8) were highly expressed in thyroid cancer tissues and cell lines. DLEU2 and TNRAIP8 promoted the proliferation, migration and aerobic glycolysis and restrained the apoptosis of thyroid cancer cells. DLEU2/miR-205-5p/TNFAIP8 signaling axis was identified in thyroid cancer cells. TNFAIP8 overexpression largely rescued the malignant phenotypes in DLEU2-silenced thyroid cancer cells. DLEU2 positively regulated TNFAIP8 expression by acting as miR-205-5p sponge in thyroid cancer cells. DLEU2 silencing blocked the growth of xenograft tumors in vivo.

Conclusion

lncRNA DLEU2 exerted a pro-tumor role to promote proliferation, migration and aerobic glycolysis while repressing the apoptosis of thyroid cancer cells via miR-205-5p/TNFAIP8 axis.
Novel insights in cell cycle dysregulation during prostate cancer progression
Authors: Ben-Salem Salma , Balaji Venkadakrishnan Varadha
Published: April 2021

Prostate cancer (CaP) remains the second leading cause of cancer deaths in Western men. These deaths occur because metastatic CaP acquires resistance to available treatments. The novel and functionally diverse treatment options that have been introduced in the clinic over the past decade each eventually induce resistance for which the molecular basis is diverse. Both initiation and progression of CaP have been associated with enhanced cell proliferation and cell cycle dysregulation. A better understanding of the specific pro-proliferative molecular shifts that control cell division and proliferation during CaP progression may ultimately overcome treatment resistance. Here, we examine literature for support of this possibility. We start by reviewing recently renewed insights in prostate cell types and their proliferative and oncogenic potential. We then provide an overview of the basic knowledge on the molecular machinery in charge of cell cycle progression and its regulation by well-recognized drivers of CaP progression such as androgen receptor and retinoblastoma protein. In this respect, we pay particular attention to interactions and reciprocal interplay between cell cycle regulators and androgen receptor. Somatic alterations that impact the cell cycle-associated and -regulated genes encoding p53, PTEN and MYC during progression from treatment-naïve, to castration-recurrent, and in some cases, neuroendocrine CaP are discussed. We considered also non-genomic events that impact cell cycle determinants, including transcriptional, epigenetic and micro-environmental switches that occur during CaP progression. Finally, we evaluate the therapeutic potential of cell cycle regulators and address challenges and limitations in the approaches modulating their action for CaP treatment.
PENDEKATAN STREAM (SCIENCE-TECHNOLOGY-RELIGION-ENGINEERING-ARTS-MATHEMATICS) MEMBEKALKAN KEBIASAAN BERPIKIR MAHASISWA
Authors: Agustina Tri Wahyu , Rustaman Nuryani Y , Riandi Riandi , Purwianingsih Widi
Published: April 2021

THE STREAM APPROACH (SCIENCE-TECHNOLOGY-RELIGION-ENGINEERING-ARTS-MATHEMATICS) PROVIDES STUDENTS 'THINKING HABITSAbstractThis research develops an Applied Biology learning program using a science-technology-religion-engineering-arts-mathematics (STREAM) approach that can equip students with habits of mind. These thinking habits include systems thinking skills. The Applied Biology learning content includes compost making, nata de soya making, and biopesticides making. The research was carried out in the Microbiology course on the topic of Applied Microbiology. During the lectures, the learning process combines the 3Es learning cycle model (exploration-explanation-expansion phase), Jigsaw-type cooperative, and a combination of various learning methods. Students are trained in scientific process skills and designing /engineering skills. The products of the program consisted of modifications to the syllabus and the microbiology course matrix, performance tasks on students' worksheet, the STREAM approach scheme, system thinking skills' question instruments, concept map rubrics and scores. The resul indicate that system thinking skills in Applied Biology learning content could be equipped to students using the STREAM approach. AbstrakPenelitian mengembangkan program pembelajaran Biologi Terapan menggunakan pendekatan science-technology-religion-engineering-arts-mathematics (STREAM) yang dapat membekalkan kebiasaan berpikir. Kebiasaan berpikir tersebut diantaranya keterampilan berpikir sistem (KBS). Konten Biologi Terapan antara lain pembuatan kompos, nata de soya, dan biopestisida. Penelitian dilaksanakan pada perkuliahan Mikrobiologi pada pokok bahasan Mikrobiologi Terapan. Selama pembelajaran memadukan model siklus belajar 3Es (fase eksplorasi-pengenalan konsep-aplikasi konsep), kooperatif tipe Jigsaw, dan kombinasi metode belajar. Mahasiswa dilatihkan keterampilan proses saintifik dan mendesain (engineering). Produk program terdiri dari modifikasi pada silabus dan modifikasi matriks perkuliahan Mikrobiologi, tugas kinerja (task) pada lembar kerja mahasiswa (LKM), skema pendekatan STREAM, instrument soal KBS, dan skor beserta rubrik peta konsep. Hasil penelitian mengidikasikan bahwa KBS dapat dibekalkan kepada mahasiswa menggunakan pendekatan STREAM.
DEVELOPMENT OF SCIENCE TEST TO MEASURE HOTS AND DIGITAL LITERACY OF JUNIOR HIGH SCHOOL STUDENTS ON THE TOPIC OF CITY NOISE
Authors: Nurwahidah Indri , Widiyawati Yeni , Sari Dwi Septiana , Masykuri Mohammad , Budiyanto Cucuk Wawan
Published: April 2021

PENGEMBANGAN SCIENCE TEST UNTUK MENGUKUR HOTS DAN DIGITAL LITERACY SISWA SMP PADA TEMA KEBISINGAN KOTA AbstractThe 2013 Curriculum emphasizes the process to improve HOTS and digital literacy. However, no appropriate science test instrument can measure the combination of these two aspects in contextual topics and relate to real-world problems. This kind of science test will engage students in-depth thinking as well as improve their digital literacy. This research aims to develop science tests based on HOTS and digital literacy in the City Noise theme for 8th-grade students. HOTS is operationally defined as critical thinking, creativity, collaboration, and communication (4C), while digital literacy is a thinking and operation skill. Borg & Gall models were adopted in this research and development. A total of 21 private school students in Semarang were subject to this research and investigated the validity and reliability of developed science tests. Based on expert judgment, the science test instrument, which consists of 25 multiple choice items and five essay items, was in a very good category. Based on the Rasch model analysis, the science tests are valid (28 items are valid) and reliable (Alpha cronbach=0.79). It can be concluded that the developed science test is feasible to use to measure HOTS and digital literacy of junior high school students on the topic of the City Noise.AbstrakKurikulum 2013 menekankan pada proses peningkatan HOTS dan digital literacy. Namun, belum banyak tersedia instrumen tes sains yang mampu mengukur kombinasi dari kedua aspek tersebut dalam topik yang kontekstual dan berhubungan dengan masalah nyata. Jenis science test seperti ini dapat melibatkan siswa dalam proses berpikir mendalam serta dapat meningkatkan digital literacy. Tujuan dari penelitian ini yaitu mengembangkan science test berbasis HOTS dan digital literacy pada tema Kebisingan Kota untuk siswa kelas 8. HOTS secara operasional didefinisikan sebagai critical thinking, creativity, collaboration and communication (4C) sementara digital literacy sebagai thinking skills dan operation skills. Penelitian ini merupakan penelitian pengembangan (R&D) yang mengadaptasi dari Borg & Gall. Sebanyak 21 siswa dari SMP swasta di Semarang digunakan sebagai subjek dalam penelitian ini dan digunakan untuk mengetahui validitas dan reliabilitas science test hasil pengembangan. Berdasarkan hasil validasi ahli, instrumen science test yang terdiri dari 25 item pilihan ganda dan 5 item uraian termasuk dalam kategori baik. berdasarkan hasil analisis Rasch model, science test dikatakan valid (28 item valid) dan reliabel (Alpha Cronbach=0,79). Dengan demikian dapat disimpulkan bahwa science test hasil pengembangan layak digunakan untuk mengukur HOTS dan digital literacy siswa SMP pada tema Kebisingan Kota.
HUBUNGAN ANTARA SELF REGULATED LEARNING DENGAN PROKRASTINASI AKADEMIK PADA MAHASISWA PENDIDIKAN KIMIA DI MASA PANDEMI COVID-19
Authors: Rizkyani Arivia Monique , Feronika Tonih , Saridewi Nanda
Published: April 2021

RELATIONSHIP BETWEEN SELF REGULATED LEARNING AND ACADEMIC PROCRASTINATION IN CHEMISTRY EDUCATION STUDENTS IN THE COVID-19 PANDEMIC  AbstractThe world, including Indonesia, is being hit by the covid-19 outbreak, making students adapt to a new learning process, namely online. Students need self-regulated learning to direct the learning process to achieve optimal learning goals and suppress the level of academic procrastination experienced by students during the covid-19 pandemic. This study aims to determine the relationship between self-regulated learning and academic procrastination in Chemistry Education students during the covid-19 pandemic. This study uses a correlational method with a quantitative research approach. This study's population was 210 students of Chemistry Education class 2017, 2018, and 2019 with a sample size of 68 students who were determined using the proportional stratified random sampling technique. The instruments used were self-regulated learning questionnaires, academic procrastination questionnaires, and interviews. The product-moment correlation technique is used to test the hypothesis. The results obtained a correlation coefficient value of -0.409 with a significance of 0.001, so it can be said that there is a negative and significant relationship between self-regulated learning and academic procrastination in  Chemistry Education students during the covid-19 pandemic.  Abstrak Saat ini dunia termasuk Indonesia sedang dilanda wabah covid-19 yang membuat mahasiswa harus beradaptasi dengan proses pembelajaran baru yakni melalui daring. Mahasiswa membutuhkan kemampuan self regulated learning untuk mengarahkan proses belajar dalam mencapai tujuan pembelajaran yang optimal serta untuk menekan tingkat prokrastinasi akademik yang dialami mahasiswa pada masa pandemi covid-19. Penelitian ini. bertujuan untuk. mengetahui. hubungan antara. self regulated.learning dengan. Prokrastinasi. akademik pada mahasiswa. Pendidikan Kimia di.masa pandemi covid-19. Penelitian ini menggunakan metode korelasional dengan pendekatan penelitian kuantitatif. Populasi penelitian ini adalah mahasiswa Pendidikan Kimia angkatan 2017, 2018, dan 2019 berjumlah 210 mahasiswa dengan jumlah sampel sebanyak 68 mahasiswa yang ditentukan menggunakan teknik proportional stratified random sampling. Instrumen yang digunakan berupa angket self regulated learning, angket prokrastinasi akademik, dan wawancara. Teknik korelasi product moment digunakan untuk menguji hipotesis. Hasil penelitian diperoleh nilai .koefisien korelasi sebesar. – 0,409 dengan. signifikansi 0,001 sehingga.dapat dikatakan bahwa terdapat hubungan.negatif dan signifikan.antara self. regulated. learning dengan prokrastinasi akademik pada. mahasiswa Pendidikan Kimia di.masa pandemi covid-19.
Paclitaxel- and Sirolimus-coated Balloons in Peripheral Artery Disease Treatment: Current Perspectives and Concerns
Authors: Mori Masayuki , Sakamoto Atsushi , Kawakami Rika , Sato Yu , Jinnouchi Hiroyuki , Kawai Kenji , Cornelissen Anne , Virmani Renu , Finn Aloke V
Published: April 2021

Drug-coated balloons (DCBs) have become an established therapy for the treatment of above-the-knee peripheral artery disease. The paclitaxel DCB has shown clinical benefit in terms of patency and freedom from re-intervention in multiple randomised trials. However, a recent meta-analysis has suggested an association between mortality and the use of paclitaxel-coated devices. Sirolimus is another potential choice of anti-proliferative agent for use in DCBs because of its wider therapeutic index and lower risk for dose-dependent toxicity. More recently, encapsulating sirolimus in micro-reservoirs or polymers has facilitated the development of effective sirolimus DCBs, some of which are available in Europe and Asia. In this review, the authors focus on paclitaxel and sirolimus DCB technologies from the standpoint of drug characteristics and clinical trials.
Age Limits of Criminal Responsibility for Property Offences: A New Empirical Research on Legal Consciousness in Hungary
Authors: Hollán Miklós , Venczel Tímea
Published: April 2021

This research focuses on the question whether novelties of criminal law are mirrored in legal consciousness. A questionnaire-based survey was conducted on a representative national sample of the adult Hungarian population and in this paper, the responses related to the age-limit of criminal responsibility for property offences are analysed. The hypothesis that the average person has a fragmented knowledge, even about this sector of criminal law, has been verified. It was not substantiated that this knowledge of law is substantially affected by socio-economic factors, including media consumption and encountering criminality. The cognitive answers were, however, strongly influenced by the attitudes of the respondents.1
Three-dimensional printing of tactile sensors for soft robotics
Authors: Zhou Xinran , Lee Pooi See
Published: April 2021

Three-dimensional (3D) printing has become an important fabrication method for soft robotics, due to its ability to make complex 3D structures from computer designs in simple steps and multimaterial co-deposition ability. In this article, the application of 3D printing techniques in the fabrication of four types of tactile sensors commonly used in soft robotics, including the piezoresistive tactile sensor, capacitive tactile sensor, piezoelectric tactile sensor, and triboelectric tactile sensor, will be discussed. The 3D printing mechanism, material, and structure for each type of sensor will be introduced, and the perspectives on the future potential of 3D printable tactile sensors will be discussed.
Fabrication of circuits by multi-nozzle electrohydrodynamic inkjet printing for soft wearable electronics
Authors: Khan Arshad , Rahman Khalid , Ali Shawkat , Khan Saleem , Wang Bo , Bermak Amine
Published: April 2021

Wearable electronic devices are evolving from current rigid configurations to flexible and ultimately stretchable structures. These emerging systems require soft circuits for connecting the various working units of the overall system. This paper presents fabrication of soft circuits by electrohydrodynamic (EHD) inkjet-printing technique. Multi-nozzle EHD printing head is employed for rapid fabrication of electric circuits on a wide set of materials, including glass substrate (rigid), flexible polyethylene terephthalate (PET) films, and stretchable thermoplastic polyurethane (TPU) films. To avoid the effects of substrate materials on the jettability, the proposed multi-nozzle head is equipped with integrated individual counter electrodes (electrodes are placed above the printing substrate). High-resolution circuits (50 ± 5 µm) with high electrical conductivity (0.6 Ω □−1) on soft substrate materials validate our well-controlled multi-nozzle EHD printing approach. The produced circuits showed excellent flexibility (bending radius ≈ 5 mm radius), high stretchability (strain ≈ 100%), and long-term mechanical stability (500 cycles at 30% strain). The concept is further demonstrated with a soft strain sensor based on a multi-nozzle EHD-printed circuit, employed for monitoring the human motion (finger bending), indicating the potential applications of these circuits in soft wearable electronic devices.

Graphic Abstract
Program Sakera Jempol (Sadari Kekerasan Perempuan dan Anak dengan Jemput Bola) Kabupaten Pasuruan Perspektif Yuridis
Authors: Na'mah Hadaita
Published: April 2021

This article examines the implementation of the Sakera Jempol program (Realizing the Violence of Women and Children with Ball Pick) in Pasuruan Regency and the Effectiveness of Law No. 23 of 2004 concerning the Elimination of Domestic Violence Against the Government’s Pasuruan Regency program. The data of this study are collected from observation, interviews, and documentation. Data are then analyzed using descriptive methods with inductive mindset, which describe the results of the research systematically and then seen using a juridical perspective. Based on data in the field, the Sakera Jempol Program is a program for handling victims of domestic violence, such as health services, counseling, rehabilitation, and legal assistance. The effectiveness of this program in reducing the number of violence, seen from the graph of the distribution of the number of cases of violence against women and children in the 2015-2018 period, succeeded in reducing cases from 68 cases to 21 cases of Domestic Violence (KDRT). The speed of handling victims of domestic violence is seen from the graph of the speed of handling cases of violence against women and children in the 2015-2018 period, from 5 days to 1 day. This program, if viewed from the reporting and protection stages, the handling phase, and the rehabilitation phase, is in accordance with Law No. 23 of 2004 concerning the Elimination of Domestic Violence.
Kesesuaian Pasal 108 KHI Tentang Wasiat Perwalian Anak Kepada Badan Hukum dengan Hukum Islam
Authors: Chubba Mochammad Charitsal
Published: April 2021

This is a bibliographical research that analyzes the appropriateness of article 108 of KHI (Islamic Law Compilation) concerning child trusteeship testament to legal entities with testamentary theories in Islamic law. In term of its formulation, it is known that article 108 of KHI does not have a basis and it contradicts the rules of Islamic law that exist according to the Shafi'i school of thought. In this case, there are two elements that are not in accordance with the rules of will in Islamic law, namely legal entities as recipient of will and guardianship as inherited object. It is because the legal entities are not individual recipient but an association consisting of several people who are not associated to religion and culture.  In addition, the article is only based on a number of articles contained in the Civil Code and other laws, without detailed explanations regarding the articles and procedures that must be carried out and across the norms in the community. The solution that can be taken is the need for regulations regarding the criteria of legal entities that are permitted to accept the will and their responsibilities. And there should be a change from the word trusteeship to a representative that has a limited role compared to guardianship.
Perkawinan Lansia di Kecamatan Socah Kabupaten Bangkalan Perspektif Maqasid Al-Shari’ah
Authors: Hamzah Roisul Umam
Published: April 2021

This is a field research that analyzes the marriage suitability of elderly people in Socah, Bangkalan under the theory of maqasid shari'ah. The elderly marriage is officially conducted at KUA (Religious Affairs Office) of Socah for different reasons, namely: on the basis of coercion to the bride so that the family relationship does not break up, resulting in reluctance, on the basis of family compassion and encouragement. It is because the bride is an old maid and is his own niece on the basis of mutual love, avoid immorality and seek peace of life in old age. All couples can fulfill both material and non-material obligations, although not as perfect as a young couple. Some husbands do not want to have children for fear of not being able to support even though in this case the wife really wants it. Thus, the marriage of the elderly in Socah is sometimes appropriate and not in accordance with the maqasid shari'ah. The suitability in question is in terms of hifz al-din (protecting religion) and hifz al-mal (protecting wealth), while its inadequacies are in terms of hifz al-nasl (protecting offspring), because of their desires to have offspring and in terms of hifz al-nafs (protecting soul), and hifz al-'aql (protecting ratio), because of differences in descent have the negative effect on family disharmony that can interfere with the soul and mind. In this case, an intense dialogue and approach must be made to the couple to be more open and understand each other.
Analisis Yuridis Terhadap Alasan Penemuan Novum Palsu Sebagai Dasar Peninjauan Kembali Kedua dalam Perkara Perdata
Authors: Manaqib Ulil
Published: April 2021

This article discusses the juridical analysis of the reasons for the discovery of a fake novum as the basis of a second review in a civil case. This study aims to answer the question of how are the reasons for the discovery of a fake novum as the basis for a second review in a civil case? and how are the legal analysis of a reason for the discovery of a fake novum as a the basis for a second review in a civil case. The reason for receiving the second review in the civil case is based on the discovery of a novum which was declared false by the Criminal Judge of the Bandung District Court that has inkracht, is a reason that falls within the criteria of Article 67 letter (a) which reads: “If the decision is based on a lie or a ruse the opposing party that is known after the case has been decided or based on evidence which is later declared to be false by the criminal judge”, is not classified as a reason for finding novum or the reason there are two conflicting judicial decisions. Secondly, the second review in the pedata and criminal case is only limited to the reason that there are two Judicial Decisions that are interrelated with one another (SEMA Number 10 Year 2009), so in addition to these reasons, the Supreme Court has never issued a policy related to the second mechanism Judicial Review, including on the grounds that a novum has been legally and convincingly found false by a public court.
Ekploitasi Tubuh Aktivis Perempuan Pengurus Cabang Pergerakan Mahasiswa Islam Indonesia Kabupaten Malang
Authors: Zainuri Ahmad
Published: April 2021

In implementing the works program of the Branch Management of Indonesian Islamic Students Movement of Malang Regency, for the sake of a good and interesting event, the owners of power use female activists to become workers. Women activists must carry out tasks that are not in accordance with their job descriptions, get coercion from fellow activists to carry out tasks that they themselves have not yet experienced and only try first, and the most striking is when female activists are not happy if there is a women's development program. The practice of exploitation of these women activists, seen in this article, uses Michel Foucault's body discipline theory. The body's discipline works as a normalization of behavior designed by utilizing the productive and reproductive abilities of the human body. The practice of power through disciplining the body, creates a situation where the individual body can internalize submission and make it look like a normal state. This practice is what Foucault calls the normalization of power over the individual body. Individuals will never feel that they are being used and subjugated because they already consider it to be within reasonable limits. It can also be said that this is a veiled exploitation.
Kekuatan Hukum Penyelesaian Sengketa Waris Melalui Mediator Tokoh Masyarakat di Desa Wonosalam Kecamatan Wonosalam Kabupaten Demak
Authors: Mahrus Ahmad Falih
Published: April 2021

This article is a field research to answer the role of community leaders as mediators in the settlement of inheritance disputes in Wonosalam, Demak and how the legal power of resolving inheritance disputes through mediator community leaders in Wonosalam, Demak. Research data are collected through interviews and observations, then are analyzed with descriptive analytical techniques with inductive thought pattern. Wonosalam community leaders have an important role in the settlement of inheritance disputes, namely as a mediator, including: opening and leading the mediation process, explaining and determining the heirs' parts, providing the best advice and solutions, deciding and determining what has been agreed by the parties to the dispute, preventing the emergence of even bigger disputes, and still maintaining harmony and harmony in social life. The results of the settlement of inheritance disputes through mediators of community leaders in Wonosalam do not have an enforceable legal force, because they are not confirmed by making a peace certificate or a peace agreement letter, which is contained in: article 27 of the Supreme Court Regulation No. 1 of 2016 concerning Mediation Procedures and article 1851 Civil Code. Nevertheless, the determination of community leaders as mediators in the settlement of inheritance disputes is obeyed and implemented by the people of Wonosalam.
Implementasi Isbat Nikah Massal di Madura: Kajian Sosiologis-Filosofis
Authors: Hasyim Muh. Fathoni
Published: April 2021

Marriage is a very important and sacred event in married life. Marriage is a legitimate starting point to establish kinship and brotherhood of the two extended families. So, it’s not uncommon for a wedding to be enlivened by a lively party, spending a very large budget. Nevertheless, there is a certain community in Madura that ignores it, so it does not record it in the official institution, the KUA (the Office of Religious Affairs). Even though marriage registration brings benefit, justice and protection of civil rights as well as preventive measures in preventing unawareness, so that the MWC NU of Gapura, Sumenep runs a program called “Mass Isbat Nikah”. The above problems raise two questions. Why do many isbat of marriage occur in a married couple? and how is the implementation? The review of this article will focus on how the implementation of mass marital marriage in Madura with socio-philosophical analysis.
Implementasi Sistem Informasi Manajemen Nikah Ganda: Studi Kebijakan Strategis Transformatif dan Efektivitas Hukum
Authors: Sakinah Neila , Masdar Hilmy Ahmad Arif
Published: April 2021

The web-based Marriage Management Information System (SIMKAH) is a new system that is used in the Office of Religious Affairs (KUA) Districts throughout Indonesia, replacing the desktop-based SIMKAH. Although Regulation No. 20 of 2019 regarding Marriage Registration has been passed to fully switch to web-based SIMKAH, the KUA of Gayungan, Surabaya, instead chose to implement Dual SIMKAH, which is web and desktop based. This article aims to find out the description and implementation of Dual SIMKAH in KUA of Gayungan, as well as a review of transformative strategic policies and legal effectiveness on the implementation of the Dual SIMKAH. This field research uses descriptive qualitative methods. Data mining is done through in-depth observation and interviews, as well as hands-on experience so that goals can be realized. This study produces several conclusions: (1) the implementation of Dual SIMKAH is very much needed as an anticipative effort when web-based SIMKAH experiences problems, especially in server repair, (2) the implementation of Dual SIMKAH can be assessed as a transformative strategic policy, (3) at the technical level, implementation Web-based SIMKAH still contains various problems, such as the application of Dual SIMKAH which has more support, old habits that are still inherent, the absence of announcements when the server will be repaired, and social conditions that make it impossible to switch completely to web-based SIMKAH.
Analisis Yuridis Perceraian Luar Pengadilan di Desa Nyormanis Kecamatan Blega Kabupaten Bangkalan Madura
Authors: Putri Kurnia Dwi , Eka Saputri Adinda Dian , Firdausi Nurul , Chairun Nisa Luthfia
Published: April 2021

Law in Indonesian has regulated the procedures for marriage, divorce, and reconciliation in Law No. 1 of 1974 concerning Marriage. And also stated in Law No. 22 of 1946 concerning the Recording of Divorce and Referrals. From the explanation contained in the positive law, it can be seen that the meaning of divorce is the breaking of the marriage ties of a married couple as a result of the failure to carry out the marriage due to several things such as death and court decisions. Divorce in law of Indonesian must be announced before the court. The pronouncement of divorce before the court is a mandate from article 115 of the Compilation of Islamic Law (KHI) which reads “Divorce can only be conducted in front of a Religious Court hearing after the Religious Court has tried and failed to reconcile the two parties.” But in fact, there are still many Indonesian people who do divorce not before the court. Divorce which is done outside the court is very negative, especially for the wife. Divorce is done only by word alone without going through a pledge in front of the court, then the state does not want to recognize the divorce, so that if the wife wants to remarry with another person, then it cannot be done because the wife does not have an official divorce certificate from the court.
Analisis Maslahah Mursalah Terhadap Pendapat Penghulu KUA Wonocolo Surabaya Tentang Nilai Mahar
Authors: Syamsuddin Imam Nur , Widyawati Lailatul , Rosidi M. Ainur , Dhiyaulhaq M. , Setiyahani Nova Riskiyana
Published: April 2021

This paper is the result of research using field research methods to answer two questions, that is: how is the view of the head of KUA Wonocolo in carrying out the registration of marriages with low value for dowry and how is the analysis of the mas}lah}ah mursalah in fiqh and KHI on the view of the head of KUA Wonocolo in carrying out the registration of marriage which is nominally small. Data collection in this research was taken through interviews and documentation and then the data were analyzed using editing and organizing techniques. The opinion of the head of the KUA regarding the rejection of submissions for dowry with a small penalty occurred at KUA Wonocolo, Surabaya. According to the KUA Wonocolo, the dowry price can be an indicator of marriage readiness for the bride and groom. the opinion of the head of KUA regarding the dowry boundaries used by the head of KUA Wonocolo is based on the concepts of fiqh and KHI, which then the authors analyze with the concept of maslahah mursalah. The results of this research conclude that the aim of the head of KUA Wonocolo argues that he rejects the submission of dowry with a small penalty because, it is considered not to show the seriousness of the prospective husband to foster a household with his future wife and the opinion of the head of KUA Wonocolo is in accordance with the concept of mas}lah}ah mursalah.
Tinjauan Hukum Islam Terhadap Praktik Hibah Hareuta Peunulang di Aceh
Authors: Usman Munadi
Published: April 2021

In Acehnese society, there is a tradition called hareuta peunulang, which is the practice of giving a number of assets to married girls in preparation for starting a new life with her husband. This practice is still often carried out until now, especially by people in the Pidie Regency, Aceh Besar District and parts of the West Aceh region. This practice seems to be gender-biased, which is more privileging girls and discriminating boys. This article wants to criticize the practice of hareuta peunulang grants using the theory of grants in Islamic law, with the aim of finding a contradiction between the two and offering several legal formulas to reconstruct these traditional institutions so that they are in line with the ideals of Islamic law.
Analisis Kritis Terhadap Fikih Perceraian Responsif Gender: Studi Penerapan Kaidah Maqasid al-Syari'ah
Authors: Rohman Holilur
Published: April 2021

This study discusses the application of maqasid al-shar'ah principles in the gender-responsive marriage Jurisprudence. The focus of this research is: how the principles of maqasid al-shar'ah could be used as a foundation and approach of Ijtihad? How is the application of maqasid al-shar'ah principles in the issue of gender-responsive marriage Jurisprudence? This research is a qualitative research, which is in the form of descriptive-analytical library research. The approach used is the philosophical approach. In this study it was found that there are four rules of maqasid al-shar'ah which are used as the basis for jihad. These norms was then applied in a gender-responsive divorce Jurisprudence. This research concludes, that the holder of divorce rights is male, but the divorce can be pronounced based on the court's decision so that the results are more objective. In addition, divorce must be done for certain reasons, such as the cause of a constant dispute that cannot be resolved. Therefore, divorce without cause and without dialogue with his wife, is prohibited because it gives the effect of harm especially to his wife and children.
Peran Single Mother Terhadap Penanganan Kebohongan Anak Melalui Komunikasi Interpersonal Perspektif Hukum Islam
Authors: Batunnikmah Khasib
Published: April 2021

The role of parents is very important in building a child's personality. It becomes not easy when the role is only carried out by a single mother. This article aims to examine how the effects of interpersonal communication is done by singgle mother to change the attitudes of children. The importance of doing interpersonal communication is then seen also using nass. The study was conducted on two single mother informants and their children using interview and observation methods. One of the single mother informants became the single mother because of a divorce and the other because her husband passed away. They both chose to raise their children themselves so they had to play a dual role in the family. They become mothers as well as the breadwinners of the family. This fact raises deception, which is the act of avoiding hurting others by lying, between mother and child. The existence of interpersonal communication can then minimize the existence of deceptions in the communication process which can affect the relationship between parents and children.
Islam dan Adat dalam Tradisi Perkawinan Masyarakat Suku Bugis: Analisis Interaksionisme Simbolik
Authors: Haq Abd. Sattaril
Published: April 2021

This article is intended to examine the relationship between Islam and adat in the Bugis traditional wedding procession by using symbolic interactionism analysis. The procession of the Bugis traditional wedding tradition is divided into several parts, namely mappese-pese or mabbaja laleng which is interpreted as a process to find out whether the couple to be married has a fiance or not, this is intended as a form of caution not to propose to a woman who has been proposed. by other people. Madduta is done as a form of appreciation or love among humans. Mappettu ada is meant to reinforce the outcome of the conversation and is intended to elevate the position of women in the procession. Mappacci is meant to carry out the self-cleaning process by using several traditional instruments and using the Koran and praise to the Prophet in the form of reading barazanji as its main foundation and giving leko' is meant as a form of husband's responsibility in providing for his wife. This gives legitimacy that Islam and customs in the tradition of Bugis marriage go hand in hand or a form of acceptance of the Bugis community with Islamic values described in the traditions being carried out.
RESPONSABILIDAD CIVIL Y ROBOTS INTELIGENTES: ENTRE DUDAS DOCTRINALES Y RESPUESTAS TÉCNICAS
Authors: Denzinot Aude
Published: April 2021

Vamos a hablar de responsabilidad civil y de robots inteligentes. Luego hablaré sobre esas dudas doctrinales que tenemos en Francia, y las respuestas que tenemos para disipar esas dudas. Les voy a pedir un trabajo adicional, además de escuchar la conferencia muy juiciosamente: me gustaría que hagan en su cabeza un trabajo de Derecho Comparado. Como lo saben, el Derecho francés y el colombiano son muy parecidos. Pero sí toca hacer el trabajo. Ustedes deben preguntarse y reflexionar cómo se resolverían casos concretos con los robots en Colombia.
XXVIII RUSSIAN NATIONAL CONGRESS “MAN AND MEDICINE”. COLLECTION OF ABSTRACTS.
Authors: Editorial Article
Published: April 2021

XXVIII RUSSIAN NATIONAL CONGRESS “MAN AND MEDICINE”.

COLLECTION OF ABSTRACTS.
Super sewer: safely progressing London’s Tideway tunnel through a global pandemic
Authors: Alder Andy
Published: April 2021

Work is continuing on London’s new £4.2 billion ‘super sewer’ following a review of procedures tiggered by the Covid-19 pandemic. Programme director Andy Alder of Jacobs gives a further update on this major river clean-up programme, which is now scheduled for completion in 2025.
Tubuloglomerular Feedback Synchronization in Nephrovascular Networks
Authors: Zehra Tayyaba , Cupples William A. , Braam Branko
Published: April 2021

To perform their functions, the kidneys maintain stable blood perfusion in the face of fluctuations in systemic BP. This is done through autoregulation of blood flow by the generic myogenic response and the kidney-specific tubuloglomerular feedback (TGF) mechanism. The central theme of this paper is that, to achieve autoregulation, nephrons do not work as single units to manage their individual blood flows, but rather communicate electrically over long distances to other nephrons via the vascular tree. Accordingly, we define the nephrovascular unit (NVU) to be a structure consisting of the nephron, glomerulus, afferent arteriole, and efferent arteriole. We discuss features that require and enable distributed autoregulation mediated by TGF across the kidney. These features include the highly variable topology of the renal vasculature which creates variability in circulation and the potential for mismatch between tubular oxygen demand and delivery; the self-sustained oscillations in each NVU arising from the autoregulatory mechanisms; and the presence of extensive gap junctions formed by connexins and their properties that enable long-distance transmission of TGF signals. The existence of TGF synchronization across the renal microvascular network enables an understanding of how NVUs optimize oxygenation-perfusion matching while preventing transmission of high systemic pressure to the glomeruli, which could lead to progressive glomerular and vascular injury.
Protocadherin 7–Associated Membranous Nephropathy
Authors: Sethi Sanjeev , Madden Benjamin , Debiec Hanna , Morelle Johann , Charlesworth M. Cristine , Gross LouAnn , Negron Vivian , Buob David , Chaudhry Sidharth , Jadoul Michel , Fervenza Fernando C. , Ronco Pierre
Published: April 2021

Significance Statement

Membranous nephropathy (MN) results from antibodies targeting an antigen in the glomerular basement membrane (GBM). The target antigens identified so far include PLA2R, THSD7A, NELL1, SEMA3B, and EXT1/EXT2. Using laser microdissection and mass spectrometry analysis, the authors identified a novel protein, protocadherin 7 (PCDH7), that is present in the GBM of a subset of patients with MN who are negative for all of the known antigens associated with MN. PCDH7 shows granular GBM staining and colocalizes with Ig in the GBM. Furthermore, antibodies to PCDH7 were detected in both the serum and kidney biopsy tissue from individuals with PCDH7-associated MN but not from controls. These findings suggest that PCDH7-associated MN defines a distinct type of MN.

Background

Membranous nephropathy (MN) results from deposition of antigen-antibody complexes along the glomerular basement membrane (GBM). PLA2R, THSD7A, NELL1, and SEMA3B account for 80%–90% of target antigens in MN.

Methods

We performed laser microdissection and mass spectrometry (MS/MS) in kidney biopsies from 135 individuals with PLA2R-negative MN, and used immunohistochemistry/immunofluorescence and confocal microscopy to confirm the MS/MS finding, detect additional cases, and localize the novel protein. We also performed MS/MS and immunohistochemistry on 116 controls and used immunofluorescence microscopy to screen biopsy samples from two validation cohorts. Western blot and elution studies were performed to detect antibodies in serum and biopsy tissue.

Results

MS/MS studies detected a unique protein, protocadherin 7 (PCDH7), in glomeruli of ten (5.7%) PLA2R-negative MN cases, which also were negative for PLA2R, THSD7A, EXT1/EXT2, NELL1, and SEMA3B. Spectral counts ranged from six to 24 (average 13.2 [SD 6.6]). MS/MS did not detect PCDH7 in controls (which included 28 PLA2R-positive cases). In all ten PCDH7-positive cases, immunohistochemistry showed bright granular staining along the GBM, which was absent in the remaining cases of PLA2R-negative MN and control cases. Four of 69 (5.8%) cases in the validation cohorts (all of which were negative for PLA2R, THSD7A, EXT1, NELL1, and SEMA3B) were PCDH7-positive MN. Kidney biopsy showed minimal complement deposition in 12 of the 14 PCDH7-associated cases. Confocal microscopy showed colocalization of PCDH7 and IgG along the GBM. Western blot analysis using sera from six patients showed antibodies to nonreduced PCDH7. Elution of IgG from frozen tissue of PCDH7-associated MN showed reactivity against PCDH7.

Conclusions

MN associated with the protocadherin PCDH7 appears to be a distinct, previously unidentified type of MN.
Striations at The Base of The Paleo-Fan and Channel Revealed by 3D Seismic Data, Offshore Cameroon
Authors: Le Anh Ngoc
Published: April 2021

DOI: 10.17014/ijog.8.1.101-107The 3D seismic data, offshore Cameroon, reveal the evidence of a Pliocene fan and a channel with a series of striations at their base. The fan and channel developing in Early Pliocene, were characterized by high amplitude reflections with bi-directional downlap on the base of the Pliocene sequence, and interpreted to be deep-water sandrich fan and channel. Pliocene channel flowed from east to west in the High Gradient Slope (HGS), whereas, the fan extended from NE to SW on the Low Gradient Slope (LGS). Individual striations have been imaged that are 20 - 50 m wide, c. 10 - 20 km long, and 4 - 8 m deep, trending NE - SW and E - W, slightly divergent patterns toward downslope. Striations are observed at the base of fan and channel suggesting the beginning of a period of unstable slope creating NE - SW slides in LGS and erosion in HGS. They were followed by the deposition of large scale fan deposits on the LGS and a series of parallel aggradational channels in the HGS. The striated unconformity at the base of the Pliocene sequence may be the result of a major tectonic uplift event or significant climate changes.
Geomorphological and Sedimentological Features of River Sadong, Sarawak, Malaysia
Authors: Omorinoye Omolayo Ajoke , Assim Zaini Bin , Jusoh Ismail Bin
Published: April 2021

DOI: 10.17014/ijog.8.1.119-130The effect of topography, climate, soil, and geology on River Sadong sediments is related to its geochemistry. Eighteen surface sediments and five core samples were collected in replicates from six sampling sites along River Sadong, Sarawak, Malaysia. The main aim of this study is to describe the geomorphology and sedimentological characteristics of the river sediments. This was achieved by the study of the processes that form the sediments and influence their physical and chemical characteristics. The sediments were analyzed for their sedimentological characteristics. The results indicated that the studied area is enriched with organic matter, and there are no sedimentary structures in its vicinity.
Depositional Environment of Fine-Grained Sedimentary Rocks of the Sinamar Formation, Muara Bungo, Jambi
Authors: Zajuli M. Heri Hermiyanto , Panggabean H.
Published: April 2021

DOI: 10.17014/ijog.v8i1.153The research area is situated in the northwestern side of South Sumatra Basin, which is a part of Muara Bungo Regency, Jambi Province. The Oligocene Sinamar Formation consists of shale, claystone, mudstone, sandstone, conglomeratic sandstone, and coal-seam intercalations. This research was focused on fine sedimentary rock of Sinamar Formation, such as shale, claystone, and mudstone. Primary data were collected from SNM boreholes which have depths varying from 75 m up to 200 m, and outcrops that were analyzed by organic petrographic method, gas chromatography-mass spectrometry (GC-MS) of normal alkanes including isoprenoids, and sterane. The dominant maceral group is exinite, composed of alginite (3.4 - 18%), and resinite (1.6 - 5.6%), while vitrinite maceral consists of tellocolinite 0.4 - 0.6%, desmocollinite 0.4%, and vitrodetrinite 8.4 - 16.6%. Organic petrography and biomarker analyses show that organic materials of shales were derived from high plants and algae especially Botrycoccus species. Botrycoccus and fresh water fish fossil, found in the shale indicate a lacustrine environment.