bluuebunny/crossref_metadata_2025 huggingface dataset:
Протизапальні властивості стандартизованої рослинної композиції BNO 2103 у щурів з флогоген-індукованим набряком стопи
Authors: Черних В. В. , Шебеко С. К. , Зупанець К. О.
Published: June 2022

Канефрон® Н – відомий препарат для лікування сечостатевих захворювань. Одним з його ключових ефектів є протизапальний, що було показано низкою досліджень. Патогенез хронічної хвороби нирок (ХХН) асоційований зі запаленням, тому пошук ефективних протизапальних засобів є актуальним. Оскільки досліджений спектр ефективності засобу базується тільки на частині нозологій з групи ХХН, вважали за доцільне вивчити нюанси механізмів протизапальної дії стандартизованої рослинної композиції BNO 2103, що є активним інґредієнтом Канефрону® Н. Позитивні результати можуть бути обґрунтуванням розширення спектра застосування BNO 2103.  

Мета дослідження – вивчити протизапальні властивості стандартизованої рослинної композиції BNO 2103 на моделях набряку стопи в щурів, викликаного різними флогогенами (карагенін, простагландин Е2). Експериментальне дослідження проводилось на 60 самцях білих безпородних щурів вагою 150–200 г, які були розподілені на 2 серії по 30 тварин, кожна серія включала 3 групи. Запалення моделювали за допомогою субплантарного введення флогогенів – карагеніну та простагландину Е2. Досліджувану композицію та препарат порівняння – диклофенак натрію – вводили внутрішньошлунково одноразово. Спостереження, фіксування об’єму набряку та оцінювання протизапальної активності відбувались за 0,5; 1; 2 і 3 год після введення карагеніну через 0,5; 1 і 2 год після введення простагландину Е2. Композиція BNO 2103 проявила виражену антиексудативну дію на моделі карагенінового набряку, за якою поступалася препарату порівняння диклофенаку натрію, який є неселективним інгібітором циклооксигенази. На моделі простагландинового набряку композиція BNO 2103 проявила антиексудативну дію не гірше, ніж компаратор. Композиція виявила здатність інгібувати циклооксигеназний шлях перетворення арахідонової кислоти та утворення медіаторів запалення, продемонструвала значний антипростагландиновий ефект.Таким чином, стандартизована рослинна композиція BNO 2103 має значний протизапальний ефект, здійснює інгібуючий вплив на ексудативне запалення, викликане різними флогогенами (карагенін, простагландин Е2), пригнічуючи циклооксигеназний шлях перетворення арахідонової кислоти, що, найімовірніше, зумовлено наявністю в складі засобу флавоноїдів, ефірних олій і фенольних сполук. Це дозволяє розглядати BNO 2103 як перспективний антифлогістик для лікування запальної патології нирок.
Aplicación del método odontológico de carrea para la identificación forense. Relación entre la estatura real con la estimada
Authors: Brito Arízaga Joseline Elizabeth , Cáceres Manzano Verónica Paulina , Galarza Pazmiño María de los Angeles , Quintana Yánez Jorge Marcelo , Machado Jessica Paola
Published: June 2022

La antropología forense valora varias características específicas del individuo como pueden ser talla, sexo y patrón racial para individualizar e identificar cadáveres en estados de putrefacción o fase de reducción esquelética, teniendo como premisa un estudio comparativo entre la información premorten y posmorten. Los dientes gracias a su disposición anatómica y composición se conservan indemnes por largos periodos de tiempo, conservando información trascendental para la identificación. El objetivo de la investigación fue establecer la estatura de una persona a partir de las dimensiones de las estructuras dentales en los alumnos de 3er semestre de la Carrera de Odontología de la Universidad Nacional de Chimborazo, donde se realizó una investigación cuantitativa de corte transversal, correlacional de comprobación de hipótesis. Cincuenta (50) modelos de estudio fueron recolectados, en los cuales se determinaron las medidas mesio-distales de las piezas anteroinferiores tanto del lado derecho como izquierdo. Los datos fueron registrados en una ficha de recolección de datos mediante la técnica de observación, aplicando el Método Carrea. Después de haber realizado un análisis estadístico se concluyó que no existe diferencia significativa entre la estatura real y la obtenida mediante el Método Carrea, volviéndola una fórmula factible para la determinación de la estatura en la identificación.
Peripartum Dilated Cardiomypathy
Authors: Noor Serajun , Mottalib Md Abdul , Hoque Md Nurul , Mostafa Hasan , Alam Md Kowsar , Uddin Md Nizam
Published: June 2022

Peripartum Cardiomyopathy is the development of heart failure in the last trimester pregnancy or with in six month after delivery without an identify cause in a previously healthy Female . It is a uncommons condition with better prognosis. We demonstrate eight cases of peripartum Cardiomypathy presented with sign symptoms of heart failure of different severity & was confirmed by Echocardiography.
JCMCTA 2013; 24 (1):5-8
Evaluation of Gabapentin on Postoperative Pain and Opioid Consumption Following Laparoscopic Cholecystectomy
Authors: Siraj Sadat Bin , Maruf Abdullah Al , Haq Md Naimul , Yasmin Farhana , Rahaman Md Aminur
Published: June 2022

Gabapentin is reported to possess antihyperalgesic and antiallodynia properties. Recently, reports have indicated that gabapentin may have a place in the treatment of postoperative pain. In this study, we sought to role of preoperative use of gabapentin on postoperative pain and pethidine consumption following laparoscopic cholecystectomy. Sixty patients of both sexes, ASA grade I and II underwent laparoscopic cholecystectomy were randomly allocated into two groups. Group A (n = 30) patients were premedicated with single dose of gabapentin (600 mg) 2 hours before operation and Group B (n = 30) with tab vitamin B complex as placebo. Operation was done under general anaesthesia. Postoperative analgesia was assessed in both groups subjectively by Visual Analogue Scale (VAS). Any patient of both groups with VAS score of more than three were administered intramuscular pethidine 1.5 mgkg-1 bodyweight for 24 hours. VAS Observations were made in postoperative ward at arrival and at 6, 12 and 24 hours for 24 hours. Total postoperative pethidine consumption and post operative side effects were also recorded. Baseline data were comparable between the two groups. The mean VAS almost similar and less than 3 at different reading in both groups and the differences were statistically not significant. The mean total cumulative amount of pethidine administered over 24 hrs period was less in group A it was 117.31+14.13mg (Mean = SD) and in group B was 221.23=16.25 mg (Mean + SD) and the difference was statistically significant (p<0.01). Incidences of side effects like PONV and urinary retention were more in group B than group A and differences were statistically significant (p<0.01). Dizziness and Somnolence were more in group A than group B and difference was statistically significant (p<0.01). Preoperative gabapentin significantly decreased postoperative opioid consumption and should be considered a potentially useful adjunctive in postoperative pain in patients undergoing laparoscopic cholecystectomy.
JCMCTA 2013 ; 24 (1): 41-45
Chronic Puerperal Uterine Inversion : A Case Report
Authors: Sharmin Shahanaj , Alam Didarul , Begum Moquaddes Akter , Ahmed Mohiuddin
Published: June 2022

Inversion of utirus in a life threatening condition with a mortality rate of about 15%- We report an uncommon case of chronic puerperal uterine inversion. Our case is a 35-years old patient, para three full term normal vaginal deliveries reported to the gynecological outpatient department of Bangabandhu Memorial Hospital, University of Science & Technology Chittagong (USTC) Chittagong with a history of irregular per vaginal bleeding, sensation of something coming down per vagina, offensive vaginal discharge and anemia since her last delivery twelve years ago. A thorough clinical examination and radiological investigation including ultrasonography revealed chronic complete(stage II) puerperal Uterine inversion. The patient was treated with laparotomy followed by Haultain procedure subsequently hysterectomy done. We present one such case due to the rarity of this condition and the diagnostic dilemma it presents in the non puerperal stage.
JCMCTA 2013; 24 (1):64-66
A Young Patient With Multiple Myeloma
Authors: Karim ASM Ahsanul , Safder Mamoon Ur Rashid , Khan Munir Ahsan , Uddin Kamal , Ahsan Amimul , Jabed Syed Md , Rahman Azizur
Published: June 2022

Summary Multiple myeloma, generally a disease of the elderly, is a complex disorder that causes a multitude of clinical symptoms and signs and therefore presents significant diagnostic challenge to the clinician specially if the age of onset is unusually early. Here we present one young patient suffering from multiple myeloma.
JCMCTA 2013; 24 (1):67-69
Antiplatelet Therapy In Ckd
Authors: Dutta Pradip Kumar , Dutta Arup
Published: June 2022

Chronic kidney disease (CKD) patients are at increased risk of cardiovascular events (CVE) than general population. Antiplatelet agents (APA) reduce CVE in patients with normal kidney function. Whether they are of same efficacy and safety in CKD population is questionable because most of the studies did not include CKD population in their trial of APAs. At one hand there is poor response to APAs because of altered metabolism, on the other hand there is paradoxical more risk of major bleeding. This review will, address these issues of APAs use in CKD.
JCMCTA 2013; 24 (1):70-75
Results Of Excision Of Dorsal Spinal Meningioma With Severe Neuro Deficits
Authors: Awwal MA , Sakeb Najmus , Forhad Sheikh , Siddiqui Irfanul Huq , Alam Md Shamsul
Published: June 2022

Although being a slow growing tumor, spinal meningiomas are often diagnosed late and presents with features of significant cord compression that essentially warrants surgical management. To assess the clinical and functional outcome of excision of dorsal spinal meningioma. Within the period of July 2003 to June 2012, retrospective review of the records of 23 patients (Male:07, Female:26, age range, 34-68 years) with postoperative histological confirmation of meningioma were evaluated. Pre- and postoperative neurological state was classified according to the Frankel scale and functional outcome was assessed according to Levy Score. Chi-squared test and z-test was used for statistical analysis using SPSS. The mean age was 48.30=03.50 years with significant female predominance. The posterior and posterolateral position was significant causing significant neuro-deficit. Satisfactory surgical results were achieved in 78.90% cases (Levy Score) and 82.82% cases (Frankel grading). Surgical resection of spinal meningiomas is a safe and effective procedure even with severe neurological deficits.

JCMCTA 2013 ; 24 (2): 14-18
Morquio Disease : A Case Report
Authors: Chowdhury Pranab Kumar , Chowdhury Dhiman , Karim Mohammed Rezaul , Gosh Sankar Kumar
Published: June 2022

Mucopolysaccharidoses (MPS) are hereditary progressive metabolic disorder caused by the absence or malfunctioning of lysosomal enzyme needed to breakdown molecule called glycosaminoglycan (GAGS) [1]. The major GAGS are chondrotin 4 sulfate, heparin sulfate, dermaten sulfate and hyaluranan. People with mucopolysacaride disease either do not produce enough one of the enzyme required to break down these sugar chain into simple molecule or they produce enzyme that don't work [2]. Morquio disease (MPS IV) is caused by a deficiency of Nacetylgalactosamine-6-sulfatase (MPS IV-A) or of B-galactosidase (MPS IV-B). Both result in the defective degradation of keratan sulfate [2,3]. The incidence of MPS is between 3.5 to 4.5/100000. The most common subtype is MPS III. Our case is a 8 month old son of a non-consanguineous parents from Sandwip, Chittagong, admitted to the Department of Paediatrics, Chittagong Medical College Hospital with a history of gibbus at thoracolumber region for last two months. But on examination he was found to be macrochphalic, stunted and wasted. Skeletal survey had shown some consistent findings of Morquio disease and his urine for Mucopolysaccharidoses screening test is also positive. We have reported this case of MPS as it is rarer and among the MPS, Morquio disease is also not a commoner one [4,5). It is also necessary for early differentiation of MPS IV from some treatable clinical entity like congenital hypothroidism.

JCMCTA 2013 ; 24 (2): 48-50
ISU DAN TANTANGAN DALAM PENGIMPLEMENTASIAN PROGRAM JAMINAN KESEHATAN DI INDONESIA
Authors: Arifuddin Rachmad Miftachul
Published: June 2022

There is evidence that the existence of Universal Health Insurance Coverage could increase household welfare, particularly, in their consumption. However, there is disagreement in the discussion of this topic. This study examines whether the Universal Health Insurance program in Indonesia could increase household consumption among self-employed citizens. Using household panel datasets about household consumption, household characteristics, and community characteristics for a large sample of Indonesian population over period 1995-2015, we find that the participation in this program has positive impact on household consumption. This paper divides the data into four waves, consisting of five consecutive years each. By using IV we found that the estimation is relatively stable in every wave, except in the periods between 2010-2015, when new participants in the programs suddenly jumped significantly.
Effectiveness of Anchoring with Balloon Guide Catheter and Stent Retriever in Difficult Mechanical Thrombectomy for Large Vessel Occlusion
Authors: Yi Ho Jun , Kim Bum-Tae , Shin Dong-Sung
Published: June 2022

Objective : A distal navigation of a large bore aspiration catheter during mechanical thrombectomy (MT) is important. However, delivering a large bore aspiration catheter is difficult to a tortuous or atherosclerotic artery. We report the experience of anchoring with balloon guide catheter (BGC) and stent retriever to facilitate the passage of an aspiration catheter in MT.Methods : When navigating an aspiration catheter failed with a conventional co-axial microcatheter delivery, an anchoring technique was used. Two types of anchoring technique were applied to facilitate distal navigation of a large bore aspiration catheter during MT. First, a passage of aspiration catheter was attempted with a proximal BGC anchoring technique. If this technique also failed, another anchoring technique with distal stent retriever was tried. Consecutive patients who underwent MT with an anchoring technique were identified. Details of procedure, radiologic outcomes, and safety variables were evaluated.Results : A total of 67 patients underwent MT with an anchoring technique. Initial trial of aspiration catheter passage with proximal BGC anchoring technique was successful for 35 patients (52.2%) and the second trial with distal stent retriever anchoring was successful for 32 patients (47.8%). Overall, navigation of a large bore aspiration catheter was successful for all patients (100%) without any procedure related complications.Conclusion : Our study showed the usefulness of anchoring technique with proximal BGC and distal stent retriever during MT, especially in those with an unfavorable anatomical structure. This technique could be an alternative option for delivering an of aspiration catheter to a distal location
THE EVALUATION OF THE CHANGE IN THE CONSTITUTIONAL COURT'S DECISIONS ON WOMEN'S RIGHTS WITHIN THE FRAMEWORK OF PIERRE BOURDIEU'S THEORY OF LAW
Authors: DEĞİRMENCİ Rıdvan
Published: June 2022

Bu çalışmanın amacı Anayasa Mahkemesi’nin kadın haklarına dair bazı içtihatlarında yaşanan değişimi açıklamaktır. Pierre Bourdieu’nun yargıya bakışı, Anayasa Mahkemesi’nin kadın haklarına dair kararlarındaki değişimin anlaşılmasında yol göstericidir. Anayasa Mahkemesi, 1990’lı yıllarda Medeni Kanun ve Ceza Kanunu’nda yer alan kadın erkek eşitliliğine aykırı düzenlemeleri iptal etmiştir. İptal kararlarında kadın erkek eşitliğinin sağlanması için uluslararası insan hakları sözleşmelerine atıfla hak temelli yorumlar yapılmıştır. Bununla birlikte, Anayasa Mahkemesi, laiklik ilkesi ile çatışan durumlarda kadın haklarını genişleten yorum yönteminden sapmıştır. Diğer kararlarında uluslararası normlara oldukça geniş yer veren Mahkeme, kadın haklarına ilişkin bazı kararlarında katı bir laiklik tanımı yaparak hakları daraltıcı şekilde içtihatlar geliştirmiştir. Bu daraltıcı yorum metodu, kadın erkek eşitliğinin sağlanmasında önemli bir eşik olan kadının soyadına ilişkin kararlarında da görülmektedir. Ancak bu daraltıcı içtihatlar 2010’lu yıllardan itibaren mahkeme üyelerinin insan hakları temelli yorumları esas almaları ile değişmiştir. İçtihatların değişiminde kurumsal gelişimin yanında Anayasa Mahkemesi üyelerinin farklı siyasi ve sosyal yapılardan gelmeleri önemli rol oynamıştır. Bourdieu’nun yargısal alandaki mücadelelerde hukukçuların rolüne dair çıkarımlarından, kadın haklarına dair kararların değişim dinamiklerinin izahını sağlamada yararlanılabilir.
Encourage resource governance: Responding disaster threats behind environmentally friendly claims at the Tumpang Pitu gold mine
Authors: Octastefani Theresia , Kusuma Bayu Mitra A. , Hentika Niko Pahlevi
Published: June 2022

The Indonesian constitution has stated that natural resources must be utilized for the people’s benefit. But the people’s interests are often defeated by the elite. The long-term goal of this research is not to close the mining area and its activities, but to ensure that the exploration and exploitation process that has already started must prioritize ecological balance and disaster resilience. Using a qualitative method and a descriptive approach, this study analyzes the role of the government, corporation, and local communities in the framework of resources governance in order to strengthen the advocacy of civil society who are often marginalized in the existence of extractive industries. The results of the study show that the gold mining activity is contrary to the forestry law where the existing rules have been liberalized by selling state assets to private companies; the lack of added value for local communities such as limited job vacancies; the occurrence of environmental damage around the gold mining area where this area is actually a protected forest and a natural barrier from the threat of a tsunami disaster; and even though mining companies have claimed that their activities are environmentally friendly, in fact disasters are starting to appear.
Measuring the task force of sexual violence prevention and response effectiveness in Jakarta State University
Authors: Andrianika Siska , Priyadi Agus , Thaufik Oktodila Hasbi , Ichsan Nusapati Achmad
Published: June 2022

The issue of the Regulation of the Minister of Education, Culture, Research and Technology of the Republic of Indonesia Number 30 of 2021 proves the seriousness of the government in dealing with sexual violence in universities. One form of prevention in this Ministerial Regulation is the establishment of a Task Force for the Prevention and Handling of Sexual Violence. This task force aims to be the main factor of dealing with various forms of sexual violence that can occur in universities, all includes prevention, reporting, to handling. Based on the importance of the existence of the task force, this study aims to analyze the effectiveness of establishing The Task Force of the Sexual Violence Prevention and Response in universities based on the Regulation of the Ministry of Education, Culture, Research, and Technology of the Republic of Indonesia in 2021. This study uses a mixture of quantitative and qualitative methods with data samples taken from the State University of Jakarta. This research data collection technique was carried out by distributing questionnaires and conducting a literature review using the theory of effectiveness and the use of law and the concept of roles. This research found that through quantitative research, there is significant correlation between the principles of the Sexual Prevention and Response, The Task Force’s main responsibility, and the objectives of this ministrial regulation. Through qualitative research, from the organizational component and the implimentation of gender-based regulation, this ministrial regulation is proven to be an effective regulation to handling sexual violence.
Kepentingan Ideologis Negara dan Nahdlatul Ulama dalam Pembubaran Hizbut Tahrir Indonesia
Authors: Fauzi Ahmad Irfan , Kosandi Meidi
Published: June 2022

This article discussed the contestation of ideological interests between the state, Hizbut Tahrir Indonesia (HTI), and Nahdlatul Ulama (NU) in the case of the disbandment of HTI in 2017. The disbandment of HTI explained the existence of pro and contra groups and the attraction of ideological interests. This research was qualitative research with observation and interview methods. The research results proved that there were conflicting and conflicting interests between the interests of the state, HTI, and NU. The state interests were the interests of the Pancasila ideology and public security. NU rejected the caliphate because it was interested in defending the "Islam Nusantara" ideology. NU's success in encouraging the government was influenced by the issues' relevance and the condition of the political structure of Joko Widodo's government for the 2014-2019 period. The polarized condition of the government's political structure in the Jokowi versus Prabowo group influenced the decision to disband HTI because NU was identified with moderate Islam that supported Jokowi. Hence, NU's bargaining power with the Jokowi government was more substantial than HTI.
DATA MINING USING RANDOM FOREST, NAÏVE BAYES, AND ADABOOST MODELS FOR PREDICTION AND CLASSIFICATION OF BENIGN AND MALIGNANT BREAST CANCER
Authors: Imran Bahtiar , Hambali Hambali , Subki Ahmad , Zaeniah Zaeniah , Yani Ahmad , Alfian Muhammad Rijal
Published: June 2022

This study predicts and classifies benign and malignant breast cancer using 3 classification models. The method used in this research is Random Forest, Naïve Bayes and AdaBoost. The prediction results get Random Forest = 100%, Naïve Bayes = 80% and AdaBoost = 80%. Results using Test and Score with Number of Folds 2, 5 and 10. Number of Folds 2 Random Forest model Accuracy = 95%, Precision = 95% and Recall = 95%, Naïve Bayes Accuracy = 93%, Precision = 93% and Recall 93%, AdaBoost Accuracy = 90%, Precision = 90% and Recall = 90%. With Number of Folds 5 with Random Forest = 96%, Precision = 96% and Recall 96%. Naïve Bayes Accuracy value = 94%, Precision = 94% and Recall = 94%, AdaBoost Accuracy value = 93%, Precision = 93% and Recall = 93%. With Number of Folds 10 Random Forest model = 96%, Precision = 96% and Recall 96%. Naïve Bayes Accuracy value = 94%, Precision = 94% and Recall = 94%, AdaBoost Accuracy value = 92%, Precision = 92% and Recall = 92%. Of the 3 models used, Random Forest got the best classification results compared to the others.
DECISION SUPPORT SYSTEM FOR PALM PLANTATION LAND SELECTION USING THE TOPSIS METHOD
Authors: Nuraini Rini , Liesnaningsih Liesnaningsih , Handayani Nurdiana , Rusdianto Hengki
Published: June 2022

Palm oil is an important export commodity in Indonesia. Quality palm oil is produced from quality oil palm plants as well. One of the factors to be able to produce quality oil palm plantations requires the right land. For this reason, land selection is an important factor. This study aims to develop a decision support system by implementing the Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS) method for the selection of oil palm plantations. The TOPSIS method is a negative approach that is obtained by considering the shortest distance from the positive ideal solution and the farthest from the ideal solution. The system is built using a waterfall system development approach that starts from analysis, design, coding and testing. The developed system has the ability to manage alternatives, manage criteria, perform alternative calculations with TOPSIS, and display the best alternative results with TOPSIS. From the results of black-box testing, it proves that the developed system can work and run well. In addition, the results of manual calculations with the system show the same results.
IMPLEMENTATION OF THE HAVERSINE METHOD FOR THE APPLICATION OF FINDING TOURIST ATTRACTIONS IN NANGGUNG DISTRICT
Authors: Fatimah Fety , Al Ikhsan Safaruddin Hidayat , Wulandari Berlina
Published: June 2022

Traveling is one of the most popular hobbies nowadays. Natural tourist destinations located in the countryside are a choice for travelers. There are several tourist sites located in the country of Bogor, one of which is in the district of Nanggung. Nanggung sub-district is in the region of west Bogor, approximately 60 km from the capital city of Bogor Regency (Cibinong). The location of the Nanggung sub-district has an area of 135.25 km2, located near the foot of Mount Salak, creating a beautiful atmosphere and quite cold air. There are approximately 30 tourist destinations in the Nanggung sub-district. Base mobile application to help tourists determine the nearest destination. This mobile application helps domestic and foreign tourists select the closest tourist sites visited in Nanggung, Bogor Regency. The haversine method used to calculate the distance is the haversine method. The haversine method estimates the distance. Haversine will calculate the distance between the application user and the location of the surrounding tourist points located in the Nanggung sub-district. This study aims to calculate the length of application users to tourist sites. So that users get convenience in determining the closest location from the application user's position.
Auranofin attenuates hepatic steatosis and fibrosis in nonalcoholic fatty liver disease via NRF2 and NF- κB signaling pathways
Authors: Lee Seung Min , Koh Dong Hee , Jun Dae Won , Roh Yoon Jin , Kang Hyeon Tae , Oh Ju Hee , Kim Hyun Sung
Published: June 2022

Background/Aims: We aim to evaluate the effects of auranofin, a known antioxidant, on hepatic steatosis, inflammation, and fibrosis, contributing to non-alcoholic steatohepatitis (NASH) development in vivo and in vitro.Methods: Transcriptome analysis of LX-2 cells was that expression patterns of genes changed by auranofin, and their related pathways were estimated. We used the gene set enrichment analysis (GSEA) program to determine the pathway involved in overall genetic change. In vitro, LX-2 and HepG2 cells were treated with transforming growth factor (TGF)-β1 and palmitic acid (PA), respectively, and the antifibrotic and antiadipogenic effect function of auranofin was evaluated.Results: Transcriptome analysis revealed that auranofin decreased the expression of 15 genes, including thrombospondin 1, endothelin 1 (ET-1), fibronectin 1, and LOX. The molecular functions of these genes are involved in collagen binding. GSEA of the overall gene expression pattern revealed that many genes increased in the reactive oxygen species pathway and decreased in the inflammatory response. Auranofin decreased nuclear factor kappa B (NF-κB) and IκBα in TGF-β1-induced LX-2 cells, thereby reducing ET-1 and fibrosis. Furthermore, increased pNRF2 in PA-induced HepG2 cells led to increased antioxidant marker expression and decreased lipid accumulation. In the bile duct ligation model mice, auranofin reduced the fibrosis area and increased the survival rate. Auranofin reduced liver fibrosis and lipid accumulation in NASH model mice fed on a Western diet.Conclusions: Auranofin inhibits lipogenesis and fibrosis formation and is a proposed candidate for NASH treatment.
MODERN VERSIONS OF SHEVCHENKO’S ALLEGED PATERNITY
Authors: Boron Oleksandr
Published: June 2022

The creation of a new scholarly biography of Shevchenko is impossible without testing plausible assumptions and hypotheses prevalent in the mass consciousness. Most of them do not stand up to criticism and miss any detailed analysis, while others seem at first glance so convincing that they are perceived almost as a truth. Shevchenko‘s alleged paternity used to be one of the taboo issues but now it is fervently debated, attracting many — both admirers of his word and ill-wishers.

In the media, popular editions, and even outlines of the lessons available on the Internet, the idea that the poet was the father of Hanna Zakrevska’s (1822—1857) daughter, Sofiia Platonivna, married Felen (1845—?), is being replicated. Volodymyr Syrotenko (Verbytskyi),

Candidate of Technical Sciences, actively defends this view. Another hypothesis belongs to the writer Antonina Tsvyd who tries, in her research paper, to substantiate legendary folk stories about the alleged Shevchenko’s son Fedir whose mother was an unknown resident of Sedniv.

The statements and assumptions made in the publications of these authors have been critically verified by comparison with dependable information, which showed that both versions do not have any real basis and contradict properly proven facts and documents. V. Syrotenko presents his conjectures as the purest truth, while A. Tsvyd, trying to find evidence for dubious legends, resorts to assumptions devoid of logic and common sense while leaving well-known circumstances without attention. Memoirs are also misinterpreted, in particular the ones of Oleksandr Chuzhbynskyi, and it once again testifies to the urgent need for a critical edition of a corpus of memoirs about Shevchenko. It is especially unfortunate that V. Syrotenko’s inventions are recklessly picked up by the community of teachers who ‘legalize’ them in publications and the educational process.
ULUSLARARASI KURULUŞLARDA SPORUN ROLÜ
Authors: ŞAHANLI GÖKDUMAN Çiğdem , TEMEL Cenk , AKYOL Ender
Published: June 2022

Geleneksel ulus devlet yaklaşımının sorgulanması ve ulus devletlerin, küresel sorunların çözümünde yer yer yetersiz kalması sonucu toplumların/ülkelerin hak ve çıkarlarının korunmasını sağlamak amacıyla uluslararası kuruluşlar kurulmuştur. Bu kuruluşlar, küreselleşen dünyadaki gelişmelerden etkilenip, aynı zamanda bu gelişmeleri etkileyerek toplumlara, dolayısıyla da ülkelere yön vermeye çalışmaktadırlar. Bu çalışmada; Eğitim, Bilim ve Kültür Örgütü (UNESCO), Dünya Sağlık Örgütü (WHO), Birleşmiş Milletler Çocuklara Yardım Fonu (UNICEF), Avrupa Birliği, Güneydoğu Asya Ulusları Birliği, Şangay İşbirliği Örgütü, İslam İşbirliği Teşkilatı ve Afrika Birliği’nin kuruluş amaçları doğrultusunda sporu kullanım biçimleri belirlenmeye çalışılmıştır. Araştırmada nitel araştırma yöntemlerinden doküman analizi tekniğinden yararlanılmış, literatür taraması yapıldıktan sonra ilgili kuruluşların resmi web siteleri kuruluşların politik yaklaşımları açısından detaylı olarak incelenmiştir. Sonuç olarak sporun Dünya Sağlık Örgütü tarafından sağlıklı bir dünya inşa etmek, UNESCO ve UNICEF tarafından eğitime erişim imkânı sunmak, Avrupa Birliği tarafından bütüncül bir Avrupa oluşturmak için bir politika aracı olarak kullanıldığı belirlenmiştir. Güneydoğu Asya Uluslar Birliği, insanlar arası bağları geliştirerek güçlü tutmak ve bölgesindeki halklarla dayanışmayı sağlamak, Şangay İşbirliği Örgütü ise spor yoluyla “Şangay Ruhu”na bağlılığın ve üye ülkelerin halkları arasındaki sosyal uyumun sağlanması amacıyla spora ilişkin politikalar üretmektedirler. İslam İşbirliği Teşkilatı, spor organizasyonlarından yararlanarak uluslararası, kıtasal ve bölgesel düzeyde Müslüman toplumların işbirliğinin geliştirilmesi ve ayrıca bir kültür taşıyıcısı olarak sporu kullanırken, Afrika Birliği ise sömürgeleştirme ve ırk ayrımcılığını önlemek, öte yandan kıtanın kalkınması ve barış için sporu bir araç olarak kullanmaktadır. Sonuç olarak araştırmada incelenen uluslararası kuruluşların her birinin, kendi kuruluş amaçlarına ulaşmak amacıyla sosyo-ekonomik ve politik farklı uygulamalar biçiminde sporu bir araç olarak kullandıkları belirlenmiştir.
Análsis de los tratamiento farmacológicos y no farmacológicos en el síndrome de hipermovilidad articular (SHA) durante el periodo 2017 al 2021: Una revisión sistemática
Authors: Takahashi-Ferrer Carolina Mayo , Parreño-Tipian Juan Manuel
Published: June 2022

Objetivos: Analizar los tratamientos no farmacológicos y farmacológicos en pacientes con síndrome de hipermovilidad articular (SHA). Métodos: Es una revisión sistemática de trabajos de investigación, donde se siguió la recomendación PRISMA buscando artículos científicos publicada en: Redalyc, Eric, Sciencedirect, Latindex, Scopus, Alicia, Elsevier, Pubmed, LILACS, SciELO, EBSCO y Google Scholar, durante el periodo 2017 al 2021. Resultados: Del total inicial de 261019 estudios correspondientes a la búsqueda, sin aplicar filtros, se seleccionaron cuatro artículos de los cuales todas describen tratamientos no farmacológicos considerando la terapia física como la alternativa más adecuada y eficaz para fortalecer y reeducar las articulaciones, para así reducir el dolor de forma temporal. No se debe sobre esforzar y se debe respetar las limitaciones de cada paciente; de lo contrario, sería perjudicial para la salud. Por otro lado, un solo estudio de los mencionados, detalla tratamientos farmacológicos recomendando a la amitriptilina y a la fluoxetina como la opción para mitigar el dolor crónico, en presencia de crisis de dolor se recomienda el paracetamol, sin embargo se recalca que el uso de los antiinflamatorios no esteroideos (AINE) y los opiáceos ya que también podrían usarse para dolor agudo, mas no se recomiendan por no ser bien tolerados por estos pacientes debido a la fragilidad de sus tejidos por la alteración a nivel de colágeno que presentan. Conclusiones: No hay avances significativos en los últimos cinco años con respecto a tratamientos para pacientes con SHA en comparación con años pasados. Existe una mayor evidencia sobre terapia física para tratar las dolencias y sintomatología de estos pacientes en comparación a las opciones de fármacos que se puede recurrir para mitigar el dolor y reducir la sintomatología.
Chimeric Antigen Receptor T-Cells: An Overview of Concepts, Applications, Limitations, and Proposed Solutions
Authors: Alnefaie Alaa , Albogami Sarah , Asiri Yousif , Ahmad Tanveer , Alotaibi Saqer S. , Al-Sanea Mohammad M. , Althobaiti Hisham
Published: June 2022

Adaptive immunity, orchestrated by B-cells and T-cells, plays a crucial role in protecting the body from pathogenic invaders and can be used as tools to enhance the body’s defense mechanisms against cancer by genetically engineering these immune cells. Several strategies have been identified for cancer treatment and evaluated for their efficacy against other diseases such as autoimmune and infectious diseases. One of the most advanced technologies is chimeric antigen receptor (CAR) T-cell therapy, a pioneering therapy in the oncology field. Successful clinical trials have resulted in the approval of six CAR-T cell products by the Food and Drug Administration for the treatment of hematological malignancies. However, there have been various obstacles that limit the use of CAR T-cell therapy as the first line of defense mechanism against cancer. Various innovative CAR-T cell therapeutic designs have been evaluated in preclinical and clinical trial settings and have demonstrated much potential for development. Such trials testing the suitability of CARs against solid tumors and HIV are showing promising results. In addition, new solutions have been proposed to overcome the limitations of this therapy. This review provides an overview of the current knowledge regarding this novel technology, including CAR T-cell structure, different applications, limitations, and proposed solutions.
Effects of Knee Joint Angle and Contraction Intensity on the Triceps Surae Stiffness
Authors: Lin Ming , Deng Weixin , Liang Hongying , Yu Suiqing , Xu Qin , Liu Chunlong
Published: June 2022

Purpose: Monitoring the contractility of muscles assists the clinician in understanding how muscle functions as part of the kinetic system. This study investigated the effect of knee joint angles under different resistance on the stiffness of the medial gastrocnemius (MG), lateral gastrocnemius (LG), and soleus (SOL) muscles using the shear wave elastography (SWE) technique.

Methods: A total of 22 females were recruited. During isometric plantar flexion, at knee 0-degree (fully extended) and knee 90-degree (flexed 90°), the shear modulus on the MG, LG, and SOL was measured by shear wave elastography at no contraction and two intensities (40% and 80%) of maximal voluntary contraction (MVC). Shear modulus is a mechanical parameter to describe stiffness, and stiffness is a proxy for muscle contractility.

Results: There were moderate-to high-positive correlations between the active stiffness of triceps surae muscles and isometric contraction intensity (r: 0.57–0.91, p＜0.001). The active stiffness in MG and LG with extended knees was higher than that with flexed knees (p＜0.001). The active stiffness in SOL with flexed knee was higher than that with extended knee (p＜0.001).

Conclusion: Active stiffness can be considered a quantitative indicator generated by the force output of the triceps surae. Different knee joint angles cause three triceps surae muscles to exhibit non-uniform mechanical properties, which may explain part of the mechanism of soft tissue injury during physical exercise.
Advances in Barrier Membranes for Guided Bone Regeneration Techniques
Authors: Yang Ze , Wu Chang , Shi Huixin , Luo Xinyu , Sun Hui , Wang Qiang , Zhang Dan
Published: June 2022

Guided bone regeneration (GBR) is a widely used technique for alveolar bone augmentation. Among all the principal elements, barrier membrane is recognized as the key to the success of GBR. Ideal barrier membrane should have satisfactory biological and mechanical properties. According to their composition, barrier membranes can be divided into polymer membranes and non-polymer membranes. Polymer barrier membranes have become a research hotspot not only because they can control the physical and chemical characteristics of the membranes by regulating the synthesis conditions but also because their prices are relatively low. Still now the bone augment effect of barrier membrane used in clinical practice is more dependent on the body’s own growth potential and the osteogenic effect is difficult to predict. Therefore, scholars have carried out many researches to explore new barrier membranes in order to improve the success rate of bone enhancement. The aim of this study is to collect and compare recent studies on optimizing barrier membranes. The characteristics and research progress of different types of barrier membranes were also discussed in detail.
Observations of Wave Height Amplification Behind an Oyster Castle Breakwater System in a High-Energy Environment: Gandys Beach, NJ
Authors: Bredes Amy L. , Miller Jon K. , Kerr Laura , Brown Dana Rose
Published: June 2022

This study reports findings of an analysis of modifications to the incident wave field caused by constructed Oyster Castle® breakwater systems at Gandys Beach Preserve in Downe Township, NJ. The Nature Conservancy’s (TNC) Gandys Beach Preserve is a one-mile stretch of beach located along with intertidal mud flats, sandy beaches, tidal creeks, and salt marshes. Gandys Beach can be classified as a high-energy environment, with open water fetches exceeding 30 miles, and a tidal range on the order of 2 m. The Gandys Beach living shoreline project was designed and constructed by TNC in partnership with the United States Fish and Wildlife Service (USFWS) to investigate the effectiveness of various natural and nature-based features (NNBFs) in protecting and enhancing salt marshes and beaches in high (er) energy environments. Many of the NNBF techniques used at Gandys Beach, such as Oyster Castle® block breakwaters (Oyster Castles), had only been implemented at smaller scales in New Jersey prior to the project. Stevens was contracted by USFWS/TNC to evaluate the impact of the breakwater systems on incident waves. Four breakwater sections along the beach were selected to monitor wave attenuation. Month-long deployments of wave staffs and pressure sensors occurred in the summer and winter of 2019. Analysis of the data indicates that when crests of the Oyster Castles are exposed the breakwater system effectively attenuates waves. However, when the structures are submerged, wave height attenuation decreases, and under certain conditions wave heights behind Oyster Castles can be amplified more than 80%. These results are troubling, especially in areas experiencing sea level rise where the frequency of submergence will likely increase in the future. Due to the complex nature of Gandys Beach, exact mechanisms causing this amplification remain uncertain. Furthermore, transmission coefficients (Kt) above 1 are not typically modeled in existing empirical equations. Seabrook and Hall (Coast. Eng. Proc., 1998, 1 (26), 2000) is the only studied empirical formula that indicated an amplification of the Hs as observed during these field deployments and therefore was used to model Kt. However, poor agreement between the modeled and observed Kt was found and a better predictive tool is needed.
Fluorescence Detection of Cancer Stem Cell Markers Using a Sensitive Nano-Aptamer Sensor
Authors: Ding Jie , Xu Weiqiang , Tan Jing , Liu Zhifang , Huang Guoliang , Wang Shoushan , He Zhiwei
Published: June 2022

Antigen CD133 is a glycoprotein present on the surface of cancer stem cells (CSCs), which is a key molecule to regulate the fate of stem cells and a functional marker of stem cells. Herein, a novel fluorescence “turn-on” nano-aptamer sensor for quantifying CD133 was designed using hybridization between CD133-targeted aptamers and partially complementary paired RNA (ssRNA), which were modified on the surface of quantum dots (QDs) and gold nanoparticles (AuNPs), respectively. Owing to the hybridization of aptamers and ssRNA, the distance between QDs and AuNPs was shortened, which caused fluorescence resonance energy transfer (FRET) between them, and the florescence of QDs was quenched by AuNPs. When CD133 competitively replaced ssRNA and was bound to aptamers, AuNPs-ssRNA could be released, which led to a recovery of fluorescent signals of QDs. The increase in the relative value of fluorescence intensity was investigated to linearly correlate with the CD133 concentration in the range of 0–1.539 μM, and the detection limit was 6.99 nM. In confocal images of A549 cells, the CD133 aptamer sensor was further proved applicable in lung cancer cell samples with specificity, precision, and accuracy. Compared with complicated methods, this study provided a fresh approach to develop a highly sensitive and selective detection sensor for CSC markers.
Comparative Transcriptome Analysis of Shewanella putrefaciens WS13 Biofilms Under Cold Stress
Authors: Yan Jun , Yang Zhijun , Xie Jing
Published: June 2022

Shewanella putrefaciens is a Gram-negative bacterium that can cause seafood spoilage under low-temperature conditions. The bacterium easily forms biofilms to enhance its survival in challenging environments. Our previous research revealed that the biofilm formed by S. putrefaciens WS13 under the low temperature (4 °C) has larger biomass and tighter structure than at an optimum growth temperature (30 °C). In this study, comparative transcriptome analysis was further performed to get insights into the global-level of gene expression in the biofilm formed by S. putrefaciens WS13 under the refrigerating and optimal temperatures using Illumina RNA-Sequencing technique. The results revealed that a total of 761 genes were differentially expressed, of which 497 were significantly up-regulated and 264 were significantly down-regulated (p<0.05). The qRT-PCR results of randomly selected differentially expressed genes (DEGs) confirmed the RNA sequencing results. Comparison of transcriptome data revealed 28 significantly changed metabolic pathways under the cold stress, including the down-regulated chemotaxis, and motility, and up-regulated tryptophan metabolism, histidine biosynthesis, and quorum sensing, which benefited the biofilm formation of S. putrefaciens WS13 under the adverse circumstance. This study provided useful data for better understanding of the biofilm formation of S. putrefaciens, and also laid a theoretical foundation for novel vaccine and drug targets against the severe spoilage bacterium under the cold stress.
Cyclic-di-AMP Phosphodiesterase Elicits Protective Immune Responses Against Mycobacterium tuberculosis H37Ra Infection in Mice
Authors: Lu Yanzhi , Ning Huanhuan , Kang Jian , Bai Guangchun , Zhou Lei , Kang Yali , Wu Zhengfeng , Tian Maolin , Zhao Junhao , Ma Yueyun , Bai Yinlan
Published: June 2022

Many antigens from Mycobacterium tuberculosis (M. tuberculosis) have been demonstrated as strong immunogens and proved to have application potential as vaccine candidate antigens. Cyclic di-AMP (c-di-AMP) as a bacterial second messenger regulates various bacterial processes as well as the host immune responses. Rv2837c, the c-di-AMP phosphodiesterase (CnpB), was found to be relative to virulence of M. tuberculosis and interference with host innate immune response. In this study, recombinant CnpB was administered subcutaneously to mice. We found that CnpB had strong immunogenicity and induced high levels of humoral response and lung mucosal immunity after M. tuberculosis intranasally infection. CnpB immunization stimulated splenocyte proliferation and the increasing number of activated NK cells but had little effects on Th1/Th2 cellular immune responses in spleens. However, CnpB induced significant Th1/Th2 cellular immune responses with a decreased number of T and B cells in the lungs, and significantly recruits of CD4+ and CD8+ T cells after M. tuberculosis attenuated strain H37Ra infection. Besides, we first reported that CnpB could stimulate IFN-β expression transitorily and inhibit the autophagy of macrophages in vitro. In mice intranasally infection model, CnpB immunization alleviated pathological changes and reduced M. tuberculosis H37Ra loads in the lungs. Thus, our results suggested that CnpB interferes with host innate and adaptive immune responses and confers protection against M. tuberculosis respiratory infection, which should be considered in vaccine development as well as a drug target.
Examining Climate Policy-Making Through a Critical Model of Evidence Use
Authors: Tangney Peter
Published: June 2022

Evidence-based decision-making has been a focus of academic scholarship and debate for many decades. The advent of global, complex problems like climate change, however, has focused the efforts of a broader pool of scholarship on this endeavor than ever before. The “linear model” of expertise, despite obvious problems, continues to be a touchstone for many policy practitioners as well as for academic understandings of evidence development and use. Knowledge co-production, by contrast, is increasingly proposed as both the antithesis and the solution to the linear model's difficulties. In this paper I argue that, appropriately considered, both models have their uses for understanding evidence for policy, yet neither adequately accounts for the political contexts in which expert knowledge has often been asserted to address climate change. The paper proposes that the difficulty with both models lies in lingering assumptions about the information value of evidence for decision-making, the sensitivity of decision-making to scientific expertise, and the assumed mendacity or irrationality of decision-makers when they seem to fail to heed expert advice. This paper presents a model of evidence use that incorporates the aspirations of linear and co-production frameworks, while providing appropriate guidance for evaluating the role of expert knowledge in climate change policy-making.