bluuebunny/crossref_metadata_2025 huggingface dataset:
Thermal inspection for viscous dissipation slip flow of hybrid nanofluid (TiO2–Al2O3/C2H6O2) using cylinder, platelet and blade shape features
Authors: Yang Hong , Hayat Umer , Shaiq Shakil , Shahzad Azeem , Abbas Tasawar , Naeem Muhammad , Khan Sami Ullah , Labidi Taher , Kolsi Lioua , Zahid Manzoor Ahmad
Published: May 2023

Hybrid nanofluid are the modified class of nanofluids with extra high thermal performances and present different applications in automotive cooling, heat transfer devices, solar collectors, engine applications, fusion processes, machine cutting, chemical processes etc. This thermal research explores the heat transfer assessment due to hybrid nanofluid with of different shape features. The thermal inspections regarding the hybrid nanofluid model are justified with aluminium oxide and titanium nanoparticles. The base liquid properties are disclosed with ethylene glycol material. The novel impact of current model is the presentation of different shape features namely Platelets, blade and cylinder. Different thermal properties of utilized nanoparticles at various flow constraints are reported. The problem of hybrid nanofluid model is modified in view of slip mechanism, magnetic force and viscous dissipation. The heat transfer observations for decomposition of TiO2–Al2O3/C2H6O2 is assessed by using the convective boundary conditions. The shooting methodology is involved for finding the numerical observations of problem. Graphical impact of thermal parameters is observed for TiO2–Al2O3/C2H6O2 hybrid decomposition. The pronounced observations reveal that thermal rate enhanced for blade shaped titanium oxide-ethylene glycol decomposition. The wall shear force reduces for blade shaped titanium oxide nanoparticles.
Zinc chloride is effective as an antibiotic in biofilm prevention following septoplasty
Authors: Noach Noa , Lavy Eran , Reifen Ram , Friedman Michael , Kirmayer David , Zelinger Einat , Ritter Amit , Yaniv Dan , Reifen Ella
Published: May 2023

Biofilm-state bacterial infections associated with inserted medical devices constitute a massive health and financial problem worldwide. Although bacteria exhibit significantly lower susceptibility to antibiotics in the biofilm state, the most common treatment approach still relies on antibiotics, exacerbating the phenomenon of antibiotic-resistant bacteria. In this study, we aimed to assess whether ZnCl2 coating of intranasal silicone splints (ISSs) can reduce the biofilm infections associated with the insertion of these devices and prevent the overuse of antibiotics while minimizing waste, pollution and costs. We tested the ability of ZnCl2 to prevent biofilm formation on ISS both in vitro and in vivo by using the microtiter dish biofilm formation assay, crystal violet staining, and electron and confocal microscopy. We found a significant decrease in biofilm formation between the treatment group and the growth control when ZnCl2-coated splints were placed in patients’ nasal flora. According to these results, infections associated with ISS insertion may be prevented by using ZnCl2 coating, thereby obviating the overuse and abuse of antibiotics.
A cyclic behavioral modeling aspect to understand the effects of vaccination and treatment on epidemic transmission dynamics
Authors: Zobayer Abu , Ullah Mohammad Sharif , Ariful Kabir K. M.
Published: May 2023

Evolutionary epidemiological models have played an active part in analyzing various contagious diseases and intervention policies in the biological sciences. The design in this effort is the addition of compartments for treatment and vaccination, so the system is designated as susceptible, vaccinated, infected, treated, and recovered (SVITR) epidemic dynamic. The contact of a susceptible individual with a vaccinated or an infected individual makes the individual either immunized or infected. Inventively, the assumption that infected individuals enter the treatment and recover state at different rates after a time interval is also deliberated through the presence of behavioral aspects. The rate of change from susceptible to vaccinated and infected to treatment is studied in a comprehensive evolutionary game theory with a cyclic epidemic model. We theoretically investigate the cyclic SVITR epidemic model framework for disease-free and endemic equilibrium to show stable conditions. Then, the embedded vaccination and treatment strategies are present using extensive evolutionary game theory aspects among the individuals in society through a ridiculous phase diagram. Extensive numerical simulation suggests that effective vaccination and treatment may implicitly reduce the community risk of infection when reliable and cheap. The results exhibited the dilemma and benefitted situation, in which the interplay between vaccination and treatment evolution and coexistence are investigated by the indicators of social efficiency deficit and socially benefited individuals.
Cross-species comparison in nonclinical pharmacokinetics of lenvatinib by a simple HPLC with ultraviolet detection
Authors: Mizuo Hitoshi , Mano Yuji
Published: May 2023

Lenvatinib (Lenvima) is a tyrosine kinase inhibitor on the market and has been used for the treatment of various types of cancer. It is important to understand differences in pharmacokinetics (PK) between nonclinical animals and humans, and thus, we evaluated PK of lenvatinib in mice, rats, dogs, and monkeys. A simple assay for lenvatinib was developed by high performance liquid chromatography with ultraviolet detection and validated in accordance with the bioanalytical guidelines. Lenvatinib was quantifiable at 5–100,000 ng/mL using 50 μL of plasma. Accuracy and precision in the intra- and inter-batch reproducibility were within the acceptance criteria, indicating a robust assay. Lenvatinib was intravenously or orally administered to mice, rats, dogs, and monkeys to fully characterize the cross-species PK. Total clearance and volume of distribution were relatively low and bioavailability of lenvatinib was approximately 64–78% in all the species tested. PK of lenvatinib in mice and rats after oral dose was almost linear at the doses ranging from 3 to 30 mg/kg. An empirical allometric scaling successfully predicted oral systemic exposure of lenvatinib in humans. Collectively, PK profiles of lenvatinib in nonclinical animals were well characterized and were useful for PK prediction in humans.
Adaptive changes to saccade amplitude and target localization do not require pre-saccadic target visibility
Authors: Heins Frauke , Masselink Jana , Scherer Joshua-Nikodemus , Lappe Markus
Published: May 2023

The accuracy of saccadic eye movements is maintained by saccadic adaptation, a learning mechanism that is proposed to rely on visual prediction error, i.e., a mismatch between the pre-saccadically predicted and post-saccadically experienced position of the saccade target. However, recent research indicates that saccadic adaptation might be driven by postdictive motor error, i.e., a retrospective estimation of the pre-saccadic target position based on the post-saccadic image. We investigated whether oculomotor behavior can be adapted based on post-saccadic target information alone. We measured eye movements and localization judgements as participants aimed saccades at an initially invisible target, which was always shown only after the saccade. Each such trial was followed by either a pre- or a post-saccadic localization trial. The target position was fixed for the first 100 trials of the experiment and, during the following 200 trials, successively shifted inward or outward. Saccade amplitude and the pre- and post-saccadic localization judgements adjusted to the changing target position. Our results suggest that post-saccadic information is sufficient to induce error-reducing adaptive changes in saccade amplitude and target localization, possibly reflecting continuous updating of the estimated pre-saccadic target location driven by postdictive motor error.
A novel type of biochar from chitinous Hermetia illucens waste with a built-in stimulating effect on plants and soil arthropods
Authors: Bulak Piotr , Proc-Pietrycha Kinga , Kaczor Monika , Złotko Katarzyna , Polakowski Cezary , Wiącek Dariusz , Waniak-Nowicka Hanna , Zięba Emil , Waśko Adam , Oleszczuk Patryk , Bieganowski Andrzej
Published: May 2023

The breeding of insects generates waste in the form of insect excrement and feed residues. In addition, a specific chitinous waste in the form of insect larvae and pupae exuvia is also left. Recent research tries to manage it, e.g., by producing chitin and chitosan, which are value-added products. The circular economy approach requires testing new, non-standard management methods that can develop products with unique properties. To date, the possibility of biochar production from chitinous waste derived from insects has not been evaluated. Here we show that the puparia of Hermetia illucens are suitable for biochar production, which in turn exhibits original characteristics. We found that the biochars have a high nitrogen level, which is rarely achievable in materials of natural origin without artificial doping. This study presents a detailed chemical and physical characterization of the biochars. Moreover, ecotoxicological analysis has revealed the biochars’ stimulation effect on plant root growth and the reproduction of the soil invertebrate Folsomia candida, as well as the lack of a toxic effect on its mortality. This predisposes these novel materials with already built-in stimulating properties to be used in agronomy, for example as a carriers for fertilizers or beneficial bacteria.
Impact of minocycline on outcomes of EGFR-mutant non-small cell lung cancer patients treated with EGFR-TKIs
Authors: Tone Mari , Iwahori Kota , Shiroyama Takayuki , Futami Shinji , Naito Yujiro , Fukushima Kiyoharu , Miyake Kotaro , Koyama Shohei , Hirata Haruhiko , Nagatomo Izumi , Wada Hisashi , Takeda Yoshito , Kumanogoh Atsushi
Published: May 2023

Minocycline is often administered prophylactically or therapeutically to non-small cell lung cancer (NSCLC) patients receiving epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) for skin rash as an adverse event. We examined the effects of minocycline on the outcomes of EGFR-mutant NSCLC treated with first-line EGFR-TKIs based on a single-center retrospective analysis. In this retrospective cohort study, data were collected on NSCLC patients treated with first-line EGFR-TKIs between January 2010 and June 2021. The treatment efficacy of first-line EGFR-TKIs was compared between patients who received minocycline and those who did not. Median progression-free survival (PFS) with first-line EGFR-TKIs was significantly longer in the minocycline group (N = 32) than in the control group (N = 106); 714 (95% confidence interval CI 411–1247) days vs. 420 (95% CI 343–626) days, p = 0.019. A multivariate analysis including skin rash as a variable confirmed that the administration of minocycline for 30 days or longer correlated with good PFS and overall survival (OS) with first-line EGFR-TKIs (HR 0.44 [95% CI 0.27–0.73], p = 0.0014 and HR 0.50 [95% CI 0.27–0.92], p = 0.027, respectively). The administration of minocycline influenced good treatment efficacy with first-line EGFR-TKIs independently of skin rash.
UQCRFS1 serves as a prognostic biomarker and promotes the progression of ovarian cancer
Authors: Sun Qiran , Li Jiaqi , Dong Hao , Zhan Jiao , Xiong Xiaoming , Ding Jiashan , Li Yuan , He Linsheng , Wang Jing
Published: May 2023

UQCRFS1 has been reported to be highly expressed in gastric and breast cancer, but the mechanism remains unclear. The prognosis and biological functions of UQCRFS1 in ovarian cancer (OC) have not been evaluated. The expression of UQCRFS1 in EOC was detected by GEPIA and HPA websites, and the prognosis value was investigated by Kaplan–Meier analysis. Then the correlation between the UQCRFS1 gene and tumor-related signature were analyzed by Spearman correlation analysis and rank sum test. Subsequently, the expression of the UQCRFS1 gene in four ovarian cancer cell lines was detected. A2780 and OVCAR8 with the highest expression of UQCRFS1 were selected in the following biological experiments. Cell proliferation was detected by CCK8 assay, cell cycle and apoptosis were determined by flow cytometry, reactive oxygen species (ROS) production was detected by DCFH-DA, DNA damage gene mRNA expression was analyzed by RT-PCR, and AKT/mTOR pathway protein expression were also examined by western blot after siRNA transfection. We found that UQCRFS1 was high-expression in EOC and associated with poor prognosis. Spearman correlation analysis revealed that the high expression of UQCRFS1 is associated with the cell cycle, apoptosis, oxidative phosphorylation, and DNA damage. Further studies found that knockdown of UQCRFS1 cells reduced cell proliferation, cell cycle arrest at the G1 phase, increased proportion of apoptosis, ROS production, and expression of DNA damage genes, inhibited ATK/mTOR pathway. The study suggested that UQCRFS1 may be a candidated target for diagnosis and treatments in OC.
Methylated precursor leads to carbon nitride (CNx) with improved interfacial interactions for enhanced photocatalytic performance
Authors: Ohemeng Peter Osei , Godin Robert
Published: May 2023

Methylated precursors used in a facile CNx copolymerization synthesis yield modified CNx materials with better aqueous dispersibility properties for enhanced photoactivity.
Spermine-starch nanoparticles with antisense vicR suppress Streptococcus mutans cariogenicity
Authors: Lei Lei , Zhang Yue , Xu Yichen , Tian Yuting , Zhao Jialiang , Xiang Yong , Yang Huiyu , Yang Yingming , Hu Tao
Published: May 2023

We developed SSN nanovector for ASvicR delivery using natural starch spermine to protect ASvicR from nuclease degradation and achieve high transformation efficiency, inhibit EPS and cariogenicity of S. mutans, maintain oral flora homeostasis.
Metabolomics of bacterial–fungal pairwise interactions reveal conserved molecular mechanisms
Authors: Luu Gordon T. , Little Jessica C. , Pierce Emily C. , Morin Manon , Ertekin Celine A. , Wolfe Benjamin E. , Baars Oliver , Dutton Rachel J. , Sanchez Laura M.
Published: May 2023

Bacterial–fungal interactions (BFIs) were explored in pairwise co-cultures of species from the cheese rind microbiome, revealing that fungi are key contributors to small molecule mediate BFIs and are important contributors to microbiomes.
Ultrasensitive detection of gastric cancer biomarkers via a frequency shift-based SERS microfluidic chip
Authors: Huang Yong , Liu Zhengqing , Qin Xiaogang , Liu Jia , Yang Yan , Wei Wei
Published: May 2023

Highly sensitive protein biomarker detection is critical for the diagnosis of gastric cancer (GC), however the accurate and sensitive detection of low-abundance proteins in early-stage GC is still a challenge.
Cellular modifications and biomaterial design to improve mesenchymal stem cell transplantation
Authors: Wong Johnny Kuan Un , Mehta Ashish , Vũ Thu Thủy , Yeo Giselle C.
Published: May 2023

Cell delivery is a major determinant of success in mesenchymal stem cell (MSC) therapies. Cellular modifications and biomaterial-assisted approaches can enhance the engraftment, retention, and survival of implanted cells for improved tissue repair.
Targeted hollow pollen silica nanoparticles for enhanced intravesical therapy of bladder cancer
Authors: Wang Lulu , Qi Fan , Bi Luopeng , Yan Jiao , Han Xiaoqing , Wang Yanjing , Song Panpan , Wang Yanbo , Zhang Haiyuan
Published: May 2023

A novel nanopollen-based intravesical therapeutic system was developed for the improvement of intravesical therapy of bladder cancer.
Hydrolyzable emulsions as a dual release platform for hydrophobic drugs and DNA
Authors: Tebcharani Laura , Akter Nahida , Fan Di , Lieleg Oliver , Gibbs Julianne M. , Boekhoven Job
Published: May 2023

Several challenges need to be overcome when applying nucleic acids as therapeutic agents.
Development of light-induced disruptive liposomes (LiDL) as a photoswitchable carrier for intracellular substance delivery
Authors: Tsuneishi Taichi , Kojima Keiichi , Kubota Fumika , Harashima Hideyoshi , Yamada Yuma , Sudo Yuki
Published: May 2023

We developed here light-induced disruptive liposomes (LiDL) using both inward proton pump rhodopsin RmXeR and pH-sensitive liposomes. Then we demonstrated that LiDL works as a photoswitchable carrier for intracellular substance delivery.
Influence of subatmospheric pressure on bubble evolution on the TiO2photoelectrode surface
Authors: Luo Xinyi , Xu Qiang , Nie Tengfei , She Yonglu , Ye Xingmiao , Guo Liejin
Published: May 2023

The decrease of pressure leads to the increase of bubble departure diameter and the decrease of period.
The fundamental relation between electrohelicity and molecular optical activity
Authors: Garner Marc H. , Corminboeuf Clemence
Published: May 2023

The helical MOs of allene are connected to its optical activity when the symmetry of the molecule is broken. Consequently, the chiroptical response can be enabled by rational molecular design.
Cross diffusion governs an oscillatory instability in a ternary mixture with the Soret effect
Authors: Seta Berin , Errarte Ane , Mialdun Aliaksandr , Ryzhkov Ilya I. , Bou-Ali Mounir M. , Shevtsova Valentina
Published: May 2023

In a ternary mixture with the Soret effect, the interplay between cross-diffusion, thermodiffusion, and convection can lead to rich and complex dynamics, including spatial patterns and oscillations.
Mixed ligand copper(ii)-diimine complexes of 2-formylpyridine-N4-phenylthiosemicarbazone: diimine co-ligands tune thein vitronanomolar cytotoxicity
Authors: Kartikeyan Radhakrishnan , Murugan Dhanashree , Ajaykamal Tamilarasan , Varadhan Manikandan , Rangasamy Loganathan , Velusamy Marappan , Palaniandavar Mallayan , Rajendiran Venugopal
Published: May 2023

The bpy (IC50, 7 nM) and 5,6-dmp (IC50,13.57 nM) Cu(ii) complexes exhibit phenomenal cytotoxicity.
Deciphering silver nanoparticle fate in liver up to biliary excretion using HepG2/C3A spheroids in scenarios mimicking different exposure pathways
Authors: Rekik Yousr , Tardillo Suárez Vanessa , Sharma Vikas Raj , Chevallet Mireille , Gallet Benoit , Falconet Denis , Charbonnier Peggy , Kieffer Isabelle , Tucoulou Rémi , Jouneau Pierre-Henri , Veronesi Giulia , Deniaud Aurélien
Published: May 2023

This study probes the exposure route-dependent fate of silver nanoparticles by using a 3D cell model mimicking the liver. It reveals the cellular trafficking and transformation of silver species, up to their storage in vacuoles or biliary excretion.
Mechanistic studies of Ni-catalyzed electrochemical homo-coupling reactions of aryl halides
Authors: Luo Jian , Davenport Michael T. , Carter Arianna , Ess Daniel H. , Liu T. Leo
Published: May 2023

The formation of a NiII(Ar) intermediate and the NiII(Ar)/NiIII(Ar) ligand exchange pathway to generate a high-valent NiIII(Ar)2 intermediate in Ni-catalyzed electrochemical homo-coupling of aryl halides is reported.
Recycling process development with integrated life cycle assessment – a case study on oxygen transport membrane material
Authors: Johanning Melanie , Widenmeyer Marc , Escobar Cano Giamper , Zeller Vanessa , Klemenz Sebastian , Chen Guoxing , Feldhoff Armin , Weidenkaff Anke
Published: May 2023

Integrated life cycle assessment and chemical process development was conducted. The recycling process delivers material with primary-like properties and reduced environmental impact.
Reduction of surface charging effects in laser ablation ionisation mass spectrometry through gold coating
Authors: Gruchola Salome , Riedo Andreas , Schmidt Peter Keresztes , de Koning Coenraad P. , Knecht Luca N. , Tulej Marek , Westall Frances , Wurz Peter
Published: May 2023

In this study, two methods are investigated to reduce the adverse effects on spectral quality that can occur when investigating non-conductive samples with a miniature laser ablation ionisation mass spectrometer.
Unsubstituted thiophene–diketopyrrolopyrrole conjugated polymer thin films via oxidative chemical vapor deposition – electronic behavior
Authors: Charyton Marek K. , Reiker Tobias , Kotwica Kamil , Góra Monika , Zacharias Helmut , Boscher Nicolas D.
Published: May 2023

Chemical vapour deposition enables the polymerisation of N-unsubstituted diketopyrrolopyrrole derivative into polymer thin film combining H-bonding and conjugated covalent bonds, increasing conductivity and lifetime of electronically excited states.
Research progress of anticancer drugs targeting CDK12
Authors: Yan Zhijia , Du Yongli , Zhang Haibin , Zheng Yong , Lv Huiting , Dong Ning , He Fang
Published: May 2023

Structural optimization progress and future research directions of CDK12 inhibitors.
Correction: Cobalt metal–organic framework microcrystalline particles with strong electrocatalytic activity: amine controlled morphology and OER activity
Authors: Arunkumar Gunasekaran , Nantheeswaran Periyappan , Mariappan Mariappan , Kamlekar Ravi Kanth , Pannipara Mehboobali , Al-Sehemi Abdullah G. , Anthony Savarimuthu Philip
Published: May 2023

Correction for ‘Cobalt metal–organic framework microcrystalline particles with strong electrocatalytic activity: amine controlled morphology and OER activity’ by Gunasekaran Arunkumar et al., New J. Chem., 2023, https://doi.org/10.1039/d3nj01457f.
Synthesis and structure of stannane-based molecular bevel gears having substituents on a tin linker
Authors: Hosono Satoshi , Inagaki Yusuke , Setaka Wataru
Published: May 2023

Gear slippage, which is an error in correlated rotation, was suppressed by introducing bulky substituents on the bridging tin in stannane-based molecular bevel gears.
Synthesis of N-isoindolinonyl peptides via Pd-catalyzed C(sp2)–H olefination–activation and their conformational studies
Authors: Gupta Manish K. , Panda Ankita , Panda Subhasish , Sharma Nagendra K.
Published: May 2023

Isoindolinone is a constituent of several natural products that show a wide range of bioactivity, such as anticancer, antimicrobial, antiviral and anti-inflammatory properties.
Mechanistic insights into the electrochemical reduction of CO2 to CO on Ni(salphen) complexes
Authors: Realista Sara , Costa Paulo J. , Maia Luisa B. , Calhorda Maria José , Martinho Paulo N.
Published: May 2023

Ni(salphen) reduces CO2 to CO via a double reduction/protonation mechanism, and the active species binds to CO, only releasing stoichiometric amounts of CO upon exposure to air. This has been confirmed in both experimental and computational studies.
Transition metal-free and regioselective alkenyl C–S cross-coupling reaction of alkenylsulfonium salts
Authors: Wang Qiang , Wu Shuaijie , Wang Yi-Dong , Sun Jing , Han Ying , Yan Chao-Guo , Wang Lei
Published: May 2023

A novel and highly efficient strategy for the construction of diverse alkenyl sulfoxidesviatransition metal-free C–S cross-coupling of sulfenate anions with alkenylsulfonium salts is reported.
A pillar[5]arene-based artificial light-harvesting system with red emission for high-resolution imaging of latent fingerprints
Authors: Xiao Tangxin , Zhang Liangliang , Chen Dengli , Zhang Qiaona , Wang Qi , Li Zheng-Yi , Sun Xiao-Qiang
Published: May 2023

An artificial LHS with red emission based on pillar[5]arene was fabricated using 1% Nile red as the energy acceptor. The prepared powder was successfully used for high-contrast fluorescence imaging of latent fingerprints.
Cu-doped Nd0.6Sr0.4Co1−xCuxO3−δ (x = 0, 0.05, 0.1, 0.15, 0.2) as the cathode for intermediate-temperature solid oxide fuel cells
Authors: Du Xu , Li Songbo , An Shengli , Xue Liangmei , Ni Yang
Published: May 2023

Nd0.6Sr0.4Co1−xCuxO3−δ (x = 0, 0.05, 0.1, 0.15, 0.2) (NSCCx) was prepared by replacing Co with Cu.
Theoretical investigation of CO2 capture in the MIL-88 series: effects of organic linker modification
Authors: Huynh Nguyen Thi Xuan , Le Ong Kim , Dung Tran Phuong , Chihaia Viorel , Son Do Ngoc
Published: May 2023

We found a proportional relationship between the adsorption energy with the gravimetric uptake and the isosteric heat of CO2 adsorption with the volumetric uptake.
Correction: Molybdenum chloride double perovskites: dimensionality control of optical and magnetic properties
Authors: Binwal Devesh Chandra , Mudoi Prashurya Pritam , Panda Debendra Prasad , Vishnoi Pratap
Published: May 2023

Correction for ‘Molybdenum chloride double perovskites: dimensionality control of optical and magnetic properties’ by Devesh Chandra Binwal et al., Chem. Sci., 2023, 14, 3982–3989, https://doi.org/10.1039/D3SC00132F.
Iron phthalocyanine derived Fe1/h-BN single atom catalysts for CO2 hydrogenation
Authors: Leybo Denis V. , Ryzhova Anastasia A. , Matveev Andrei T. , Firestein Konstantin L. , Tarakanov Pavel A. , Konopatsky Anton S. , Trigub Alexander L. , Sukhanova Ekaterina V. , Popov Zakhar I. , Golberg Dmitri V. , Shtansky Dmitry V.
Published: May 2023

Fe1/h-BN single atom catalysts can be successfully synthesized using heat treatment of Fe phthalocyanine decorated h-BN in an oxygen atmosphere. Selectivity toward hydrocarbons can be controlled by the presence of Fe nanoparticles.
Study of the hydrogen absorption behaviour of a “number-sensitive” Mg atom: ultra-high hydrogen storage in MgHn (n = 1–20) clusters
Authors: Zhu Ben-Chao , Liu Guang-Hui , Deng Ping-Ji , Liu Chun-Jing , Liao Yan-Hua , Zeng Lu , Zhao Jun
Published: May 2023

A DFT study of MgHn (n = 1–20) clusters shows that a single Mg atom exhibits a magical ability of "odd–even recognition" of the attraction of H atoms, and MgH7 and MgH12 clusters have an impressive storage capacity of 22.69 wt% and 33.47 wt%.
A novel calcium fluorinated alkoxyaluminate salt as a next step towards Ca metal anode rechargeable batteries
Authors: Pavčnik Tjaša , Forero-Saboya Juan D. , Ponrouch Alexandre , Robba Ana , Dominko Robert , Bitenc Jan
Published: May 2023

Ca metal anode rechargeable batteries are a good alternative to Li-ion batteries due to abundant Ca metal and its low redox potential. Electrolytes are key for next-gen batteries. We prepared a new Ca[Al(hfip)4]2 salt and compared it with the state-of-the-art boron analogue.
Machine learning facilitating the rational design of nanozymes
Authors: Li Yucong , Zhang Ruofei , Yan Xiyun , Fan Kelong
Published: May 2023

Nanozymes face challenges in creating high-performance variants quickly. Machine learning shows promise in addressing this obstacle by predicting the activity, selectivity, catalytic mechanisms, optimal structures, and other features of nanozymes.
Edible polysaccharide-based ultraflexible organic transistors for nutritive electronics
Authors: Yang Yahan , Sun Baoying , Zhao Xiaoli , Yu Hongyan , Wang Bin , Li Juntong , Tong Yanhong , Tang Qingxin , Liu Yichun
Published: May 2023

A novel edible polysaccharide-based ultraflexible OFET was demonstrated for nutritive electronics.
Enhancement of electrical stability of metal oxide thin-film transistors against various stresses
Authors: Kim Youngseok , Kim Choongik
Published: May 2023

Metal-oxide semiconductors are considered promising alternative materials in the field of flat panel display industry due to their advantages, such as high mobility, transparency, uniformity, low production cost, and large-area processability.
Ultra-low cost supercapacitors from coal char: effect of electrolyte on double layer capacitance
Authors: Karimi Zahra , Moon Jaron , Malzahn Joshua , Eddings Eric , Warren Roseanne
Published: May 2023

Untreated coal char is explored as an ultra-low cost supercapacitor material in various electrolytes.
Parvimonas micra infection enhances proliferation, wound healing, and inflammation of a colorectal cancer cell line
Authors: Hatta Muhammad Nur Adam , Mohamad Hanif Ezanee Azlina , Chin Siok-Fong , Low Teck Yew , Neoh Hui-min
Published: May 2023

The gut microbiota Parvimonas micra has been found to be enriched in gut mucosal tissues and fecal samples of colorectal cancer (CRC) patients compared with non-CRC controls. In the present study, we investigated the tumorigenic potential of P. micra and its regulatory pathways in CRC using HT-29, a low-grade CRC intestinal epithelial cell. For every P. micra-HT-29 interaction assay, HT-29 was co-cultured anaerobically with P. micra at an MOI of 100:1 (bacteria: cells) for 2 h. We found that P. micra increased HT-29 cell proliferation by 38.45% (P=0.008), with the highest wound healing rate at 24 h post-infection (P=0.02). In addition, inflammatory marker expression (IL-5, IL-8, CCL20, and CSF2) was also significantly induced. Shotgun proteomics profiling analysis revealed that P. micra affects the protein expression of HT-29 (157 up-regulated and 214 down-regulated proteins). Up-regulation of PSMB4 protein and its neighbouring subunits revealed association of the ubiquitin–proteasome pathway (UPP) in CRC carcinogenesis; whereas down-regulation of CUL1, YWHAH, and MCM3 signified cell cycle dysregulation. Moreover, 22 clinically relevant epithelial–mesenchymal transition (EMT)-markers were expressed in HT-29 infected with P. micra. Overall, the present study elucidated exacerbated oncogenic properties of P. micra in HT-29 via aberrant cell proliferation, enhanced wound healing, inflammation, up-regulation of UPPs, and activation of EMT pathways.
Latent low‐rank representation sparse regression model with symmetric constraint for unsupervised feature selection
Authors: Guo Lingli , Chen Xiuhong
Published: May 2023

Unsupervised feature selection is a dimensionality reduction method and has been widely used as an important and indispensable preprocessing step in many tasks. However, real‐world data are not only high‐dimensional, but also have intrinsic correlations between data points, which are not fully utilized in feature selection. Furthermore, real‐world data usually inevitably contain noise or outliers. In order to select features from data more effectively, a sparse regression model based on latent low‐rank representation with the symmetric constraint for unsupervised feature selection is proposed. With the coefficient matrix of non‐negative symmetric low‐rank representation, an affinity matrix characterized by the correlation relationship between data points is adaptively obtained, which reveals the intrinsic geometric relationship, global structure, and discrimination of data points. A latent representation of all data points obtained from this affinity matrix is employed as a pseudo‐label, and feature selection is carried out by sparse linear regression. This method performs feature selection in the learned latent space instead of the original data space. An alternating iteration algorithm is designed to solve the proposed model, and its effectiveness and efficiency are verified on several benchmark data sets.
Dust-driven wind as a model of broad absorption line quasars
Authors: Naddaf M. H. , Martinez-Aldama M. L. , Marziani P. , Panda S. , Sniegowska M. , Czerny B.
Published: May 2023

Context. We test the scenario according to which the broad absorption line (BAL) phenomenon in quasars (QSOs) is not a temporary stage of their life. In this scenario, the BAL effect acts only if the line of sight is within a spatially limited and collimated massive outflow cone covering only a fraction of the sky from the point of view of the nucleus.

Aims. The aim is to understand the theoretical mechanism behind the massive outflow in BAL QSOs, which is important for modelling the impact of quasars on the star formation rate in the host galaxy, and, subsequently, on the galaxy evolution.

Methods. We applied the specific theoretical model of dust-driven wind that was developed to explain broad emission lines. The model has considerable predictive power. The 2.5D version of the model called failed radiatively accelerated dusty outflow (FRADO) includes the formation of fast funnel-shaped outflow from the disk for a certain range of black hole masses, Eddington ratios, and metallicities. We now interpret BAL QSO as sources that are viewed along the outflowing stream. We calculated the probabilities of seeing the BAL phenomenon as functions of these global parameters, and we compared these probabilities to those seen in the observational data. We included considerations of the presence or absence of obscuring torus.

Results. Comparing our theoretical results with observational data for a sample of QSOs consisting of two sub-populations of BAL and non-BAL QSOs, we found that in the model and in the data, the BAL phenomenon mostly occurs for sources with black hole masses higher than 108 M⊙. The effect increases with accretion rate, and high metallicities are also more likely in QSOs showing BAL features if a torus is taken into account.

Conclusions. The consistency of the model with the data supports the interpretation of the BAL phenomenon as the result of the orientation of the source. It also supports the underlying theoretical model, although more consistency checks should be made in the future.
A Characterization of the Polarity Mapping for Convex Bodies
Authors: TANG Linzeng , WANG Wei
Published: May 2023

In this paper, we establish a characterization of the polarity mapping for 1-dimensional convex bodies, which is a supplement to the result for such a characterization obtained by Böröczky and Schneider.
The Clinical Outcomes of Measured Resection and Gap Balancing Techniques in Primary Total Knee Arthroplasty: A Meta-analysis
Authors: Liu Kun , Fan Zongqing , Liu Weina , Li Li , Guan YuJun , Fu Donglin
Published: May 2023

Background At present, the clinical efficacy of measured resection (MR) and gap balancing (GB) techniques in total knee arthroplasty (TKA) is still controversial. The objective of this study was to evaluate the clinical outcome indexes of the two surgical methods through a meta-analysis.

Methods The literature was systematically searched on PubMed, EMBASE, Cochrane Library, China National Knowledge Infrastructure (CNKI), WANFANG, Weipu (VIP), and China Biomedical Literature (CBM) electronic databases inception until June 12, 2022. RevMan 5.3 software (the Nordic Cochrane Center, the Cochrane Collaboration, Copenhagen, Denmark) was used to analyze all data of this study. The Cochrane risk bias assessment tool is a risk bias evaluation criterion recommended by the Cochrane Handbook for systematic reviews.

Results Eleven studies involving 1268 knees in total were included. The main outcome indexes showed that the Knee Society Score (KSS) knee score (MD: −1.40; 95% CI: −2.57 to −0.22; p = 0.02) and KSS knee function score (MD: −3.11; 95% CI: −3.72 to −2.50; p < 0.001) in the GB group were higher 1 year after operation, while femoral component rotation angle (FCRA; MD: −0.75; 95% CI: −1.34 to −0.07; p = 0.03) and the osteotomy volume of the posterior medial femoral condyle (MD: −0.76; 95% CI; −1.13 to −0.38; p < 0.001) were greater in the GB group. In addition, there was no significant difference in the joint line change (MD: −0.03; 95% CI: −0.07 to 0.01; p = 0.16) between the two groups. Secondary outcome results showed that the knee joint range of motion (ROM) in 3 months, and the Western Ontario and McMaster University Osteoarthritis Index (WOMAC) score after 1 year were better in the GB group. However, the operation time of the MR group was shorter. In addition,
this study revealed no significant differences in post-complications between these two groups.

Conclusion Although the GB technique may not provide better radiographic results or reduce the complication rate, the recovery of joint function showed earlier improvement.
Zwischen Unterstützung und Kontrolle: Der
Qualitätsdiskurs zur informellen Pflege in
Österreich
Authors: Gebhart Verena , Vitzthum Simone
Published: May 2023

Die Sicherung von Pflegequalität gilt als ein maßgebliches Ziel
sozialstaatlichen Handelns. Dabei werden Qualitätsansprüche
vermehrt auch an die informelle Pflege gerichtet. Dieser Beitrag geht der Frage
nach, wie und warum im politischen Diskurs eine Qualitätssicherung im
informellen Pflegebereich eingefordert wird, welche Probleme der informellen
Pflege dabei adressiert werden und wie unter diesen Bedingungen unterschiedliche
Maßnahmen der Qualitätssicherung als Lösungsstrategie
legitimiert und institutionalisiert werden. Die Analyse erfolgte mittels einer
„Rahmenanalyse politischer Diskurse“. Als Material dienten alle
parlamentarischen Debatten/Enqueten rund um das Thema
„Qualitätssicherung der informellen Pflege“ für
den Zeitraum 1993 (Einführung Pflegegeld) – 2021, sowie die
Pflegevorsorgeberichte Österreichs für den Berichtszeitraum 1994
bis 2020. Die Ergebnisse deuten auf einen unterbestimmten
Qualitätsbegriff hin, der nur vage Vorstellungen davon enthält,
was oder wie qualitätsvolle Pflege zu Hause aussehen soll.
Maßnahmen der Qualitätssicherung richten sich in erster Linie
auf eine Unterstützung und Entlastung pflegender Angehöriger und
adressieren damit ein Ressourcenproblem. Ziel einer Qualitätssicherung
ist es u. a. die Pflege „in den eigenen vier
Wänden“ so lange wie möglich aufrecht zu erhalten. Dem
Staat kommen im Rahmen eines Qualitätsdiskurses vor allem
unterstützende und kontrollierende Funktionen zu, während
drängende Fragen der Pflegevorsorge in den Hintergrund treten.
Ferulic Acid: Signaling Pathways in Aging
Authors: Neopane Deepa , Ansari Vaseem Ahamad , Singh Aditya
Published: May 2023

The need for clinical remedies to the multiple age-related deficiencies in skin
function brought on by extrinsic and intrinsic causes is increased by these
demographic changes. Reactive oxygen species (ROS), mitochondrial
deoxyribonucleic acid (mtDNA) mutations, telomere shortening, as well as other
factors, contribute to the aging of the skin. In this overview, the issue of
human skin aging is introduced, along with several pathways and the protective
effects of ferulic acid in light of current patents. The complex antioxidant
effect of ferulic acid depends on the “sweeping” away of free
radicals as well as the suppression of the synthesis of ROS or nitrogen.
Furthermore, Cu (II) or Fe protonated metal ions are chelated by this acid (II).
Ferulic acid is a free radical scavenger as well as an enzyme inhibitor,
increasing the activity of enzymes that scavenge free radicals while decreasing
the activity of enzymes that speed up the creation of free radicals. AMPK
signalling, which can regulate cellular homeostasis, stress tolerance, cell
survival and proliferation, cell death, and autophagy, has recently been linked
to aging and lifespan. Therefore, Caenorhabditis elegans (C. elegans) and
rodents had longer life-spans due to specific AMPK activation. By inhibiting the
TGF-β/Smad signalling pathway, UV irradiation can reduce the
production of procollagen. Glycation changes the skin’s physical
characteristics, making it less elastic and stiffer. . Excessive free radicals
simultaneously trigger the nuclear factor kappa B (NF- κB) signalling
pathway, increasing TNF levels and matrix metalloproteinase production
(MMPs).
Fette runter mit Omega-3?
Authors: Schmiedel Volker
Published: May 2023

Immer wieder hört man, dass Omega-3-Fettsäuren die Blutfette senken. Doch was ist gesichert? Werden nur die Triglyzeride gesenkt oder auch das Cholesterin, und hier besonders das als schädlich angesehene LDL? Haben alle Omega-3-Fettsäuren diese Effekte oder gibt es Unterschiede zwischen den einzelnen Omega-3-Fettsäuren? In diesem Artikel soll die wissenschaftliche Datenlage hierzu gesichtet werden. Eine Kasuistik veranschaulicht darüber hinaus, wie die Risikoberechnung für Atherosklerose in der Praxis aussieht und wann Statine indiziert sind beziehungsweise wann eher nicht.
Efficacy and Safety of Valproic Acid in Myelodysplastic Syndrome and
Acute Myeloid Leukemia; a Narrative Review
Authors: Omidkhoda Navid , Mahdiani Sina , Samadi Sara , Rahimi Hossein , Mohammadpour Amir Hooshang
Published: May 2023

Loads of new therapeutic regimes have been turned up to manage Myelodysplastic
syndrome (MDS) and acute myeloid leukemia (AML), particularly in elderly
patients who are unfit for intensive chemotherapy. Despite accumulating
research, the best MDS and AML management approach is indeterminate.
Myelodysplastic syndrome implies a group of various hematopoietic stem cell
disorders that may progress to acute myeloid leukemia. These disorders are more
frequent in older adults. To the high rate of morbidity and abundant toxicities
related to the therapeutic approaches, also, the treatment would be challenging.
The clinical effectiveness of valproic acid, a histone deacetylase inhibitor, in
MDS and AML patients is unknown, even though it has demonstrated positive
activities to promote differentiation and apoptosis in cancer cells. We
investigated the clinical research on the effects of valproic acid in
conjunction with various drugs, including low-dose cytarabine, all-trans
retinoic acid, DNA-hypomethylating agents, hydrazine, and theophylline. We
conclude that VPA is a safe and effective treatment option for MDS and AML
patients, particularly when used in conjunction with all-trans retinoic acid,
DNA-hypomethylating drugs, and hydralazine. However, more randomized clinical
studies are required to identify an ideal regimen.
Tamoxifen Effects on Cognition and Language in Women with Breast Cancer
Authors: Sharma Saryu , Wright Heather Harris
Published: May 2023

Cognitive changes following adjuvant treatment for breast cancer (BC) are well documented following chemotherapy. However, limited studies have examined cognitive and/or language functions in chemotherapy-naive women with BC taking tamoxifen (TAM). Using ambulatory cognitive assessment, we investigated the trajectory of cognitive and language changes during early period of adjuvant endocrine treatment (TAM) in women with BC at two time periods (pretreatment and 2 months after treatment began). Four women with BC and 18 cognitively healthy age-matched controls completed three cognitive tasks using smartphones, during a short time period (5 days) and repeated them at two time periods. To determine language ability, language samples were collected at two time periods, where the participants described two stories from two wordless picture books and samples were assessed using core lexicon analyses. Wilcoxon-signed rank tests were computed to identify differences in linguistic and cognitive performances of both the groups at two time periods. No significant within-group or between-group differences were seen on the cognitive and language tasks at the two time periods; however, women with BC performed more poorly compared to the control group. We did see decline in some women with BC and not in others, in cognition and language during initial course of TAM treatment. However, the approach we used to assess these changes is valuable and innovative. This approach will help refine current research paradigms for determining cognitive and linguistic changes and will help determine if women with BC might require language intervention in the future.
Switching from electricity to light in stimulation-based therapy
Authors: Lim Alane
Published: May 2023

Molecular phototransducers can induce light-based stimulation in living cells for cardiac therapy.
Materials property prediction with uncertainty quantification: A benchmark study
Authors: Varivoda Daniel , Dong Rongzhi , Omee Sadman Sadeed , Hu Jianjun
Published: May 2023

Uncertainty quantification (UQ) has increasing importance in the building of robust high-performance and generalizable materials property prediction models. It can also be used in active learning to train better models by focusing on gathering new training data from uncertain regions. There are several categories of UQ methods, each considering different types of uncertainty sources. Here, we conduct a comprehensive evaluation on the UQ methods for graph neural network-based materials property prediction and evaluate how they truly reflect the uncertainty that we want in error bound estimation or active learning. Our experimental results over four crystal materials datasets (including formation energy, adsorption energy, total energy, and bandgap properties) show that the popular ensemble methods for uncertainty estimation are NOT always the best choice for UQ in materials property prediction. For the convenience of the community, all the source code and datasets can be accessed freely at https://github.com/usccolumbia/materialsUQ.
Controlling fluidic behavior for ultra-sensitive volatile sensing
Authors: Liu Tianqing , Zhu Yujin , Guo Lihao , Dong Hao , Zhang Min , Guo Haowen , Su Chen , Wang Di , Hu Wenwen , Haick Hossam , Wu Weiwei
Published: May 2023

Volatile organic compounds detection technology, electronic nose, is promising in various applications such as health management, environmental monitoring, public safety, agriculture, and food production. The critical point of electronic nose to achieve good recognition ability, the fundament for applications, is the generation of high-quality signal characteristics that are transduced from each sensor unit, and aided with algorithm. However, chamber without uniform fluidic state introduce sensors' locations caused artificial characteristics to make the recognition difficult, even incredible. Inspired by the structure of the nasal cavity, a small volume chamber with well-controlled fluidic behavior is designed and fabricated according to theoretical simulation. All the expected fluidic features, including uniform flow field and concentration field, are achieved, which are experimentally demonstrated by humidity and 2-hexanone detection using sensors arrays. The well controlled fluidic behaviors of volatile analytes help achieving the ultra-sensitive volatile organic compounds detection, which might shed a new light for e-nose technology to go over the gap between academics and industry.
Variable magnetic field electron spectrometer to measure hot electrons in the range of 50–460 keV
Authors: Shpilman Z. , Park J. , Nedbailo R. , Hollinger R. , Wang S. , Osovsky R. , Afeyan B. , Rocca J. J.
Published: May 2023

Resonance absorption (RA) occurs when a p-polarized electromagnetic wave, obliquely incident on an inhomogeneous plasma, tunnels past its turning point and resonantly excites an electron plasma wave (EPW) at the critical density. This phenomenon is important, for instance, in the direct drive approach to inertial fusion energy and is a particular example of a wider phenomenon in plasma physics known as mode conversion, which is crucial for heating magnetic fusion devices, such as tokamaks, via RF heating. Direct measurement of these RA-generated EPW accelerated hot electrons, with energy in the range of a few tens to a few hundreds of keV, is a challenging task due to the relatively low deflecting magnetic fields needed. The solution described here is a magnetic electron spectrometer (MES) with a continually changing magnetic field, lower at the entrance of the MES and gradually increasing toward the end, that enables the measurement of a wide spectral range of electrons with energies between 50 and 460 keV. Electron spectra taken in a LaserNetUS RA experiment were acquired from plasmas generated by irradiating polymer targets with the combination of an ∼300 ps pulse followed by a series of ten high intensity 50–200 fs duration laser pulses from the ALEPH laser at Colorado State University. The high intensity beam is designed as spike trains of uneven duration and delay pulses in order to modify the RA phenomenon.
A Nernst heat theorem for nonequilibrium jump processes
Authors: Khodabandehlou Faezeh , Maes Christian , Netočný Karel
Published: May 2023

We discuss via general arguments and examples when and why the steady nonequilibrium heat capacity vanishes with temperature. The framework is that of Markov jump processes on finite connected graphs where the condition of local detailed balance allows to identify the heat fluxes, and where the discreteness more easily enables sufficient nondegeneracy of the stationary distribution at absolute zero, as under equilibrium. However, for the nonequilibrium extension of the Third Law of Thermodynamics, a dynamic condition is needed as well: the low-temperature dynamical activity and accessibility of the dominant state must remain sufficiently high so that relaxation times do not start to dramatically differ between different initial states. It suffices that the relaxation times do not exceed the dissipation time.