bluuebunny/crossref_metadata_2025 huggingface dataset:
A Meta-Analytic Review of the Validity of the Tangram Help/Hurt Task
Authors: Kjærvik Sophie L. , Saleem Muniba , Velasquez Gertrudes , Anderson Craig A. , Bushman Brad J.
Published: November 2022

The Tangram Help/Hurt Task (THHT) allows participants to help another participant win a prize (by assigning them easy tangrams), to hurt another participant by preventing them from winning the prize (by assigning them difficult tangrams), or to do neither (by assigning them medium tangrams) in offline or online studies. Consistent with calls for continued evidence supporting psychological measurement, we conducted a meta-analytic review of the THHT that included 52 independent studies involving 11,060 participants. THHT scores were associated with helping and hurting outcomes in theoretically predicted ways. Results showed that THHT scores were not only associated with short-term (experimental manipulations, state measures) and long-term (trait measures) helping and hurting outcomes, but also with helping and harming intentions. We discuss the strengths and limitations of the THHT relative to other laboratory measures of prosocial behavior and aggression, discuss unanswered questions about the task, and offer suggestions for the best use of the task.
Revascularization improves vascular hemodynamics − a study assessing cerebrovascular reserve and transit time in Moyamoya patients using MRI
Authors: Zhao Moss Y , Armindo Rui Duarte , Gauden Andrew J , Yim Benjamin , Tong Elizabeth , Moseley Michael , Steinberg Gary K , Zaharchuk Greg
Published: November 2022

Cerebrovascular reserve (CVR) reflects the capacity of cerebral blood flow (CBF) to change. Decreased CVR implies poor hemodynamics and is linked to a higher risk for stroke. Revascularization has been shown to improve CBF in patients with vasculopathy such as Moyamoya disease. Dynamic susceptibility contrast (DSC) can measure transit time to evaluate patients suspected of stroke. Arterial spin labeling (ASL) is a non-invasive technique for CBF, CVR, and arterial transit time (ATT) measurements. Here, we investigate the change in hemodynamics 4-12 months after extracranial-to-intracranial direct bypass in 52 Moyamoya patients using ASL with single and multiple post-labeling delays (PLD). Images were collected using ASL and DSC with acetazolamide. CVR, CBF, ATT, and time-to-maximum (Tmax) were measured in different flow territories. Results showed that hemodynamics improved significantly in regions affected by arterial occlusions after revascularization. CVR increased by 16 ± 11% (p < 0.01) and 25 ± 13% (p < 0.01) for single- and multi-PLD ASL, respectively. Transit time measured by multi-PLD ASL and post-vasodilation DSC reduced by 13 ± 7% (p < 0.01) and 9 ± 5% (p < 0.01), respectively. For all regions, ATT correlated significantly with Tmax (R2  =  0.59, p < 0.01). Thus, revascularization improved CVR and decreased transit times. Multi-PLD ASL can serve as an effective and non-invasive modality to examine vascular hemodynamics in Moyamoya patients.
The Lived Experiences of Top Women Contributors to Leading Economic Education Journals
Authors: Ferrara Zachary , Asarta Carlos J.
Published: November 2022

Despite the substantial literature on women in economics, very little qualitative work has been devoted to exploring women’s lived experiences, and even less so on their presence in the economic education subfield. Through interviewing top female contributors to the three leading economic education journals, new insights regarding their experiences within the profession are presented, including challenges they have faced and addressed, the roles colleagues and institutions play in their scholarship, and how research itself fits into their overall careers.

JEL Codes: A11, A20, I23
Re-examining medical assistance in dying for mature minors in Canada: Reflections for health leaders
Authors: Campbell Sydney , Denburg Avram , Moola Fiona , Carnevale Franco A. , Petch Jeremy
Published: November 2022

In Canada, Medical Assistance in Dying (MAiD) is legal for many Canadians based on several criteria, though minors who are deemed sufficiently capable to make medical decisions (i.e. mature minors) remain ineligible. In this article, we provide insight into recent philosophical and legal evidence related to MAiD for mature minors. We begin by providing an overview of literature pertaining to MAiD for mature minors in particular (including evidence from Belgium and the Netherlands), followed by a discussion on the lessons that can be learnt from Canada’s MAiD implementation process (in general) and other forms of paediatric end-of-life care. As a whole, we aim to highlight some key takeaway messages for health leaders to consider as deliberations on MAiD for mature minors continue.
Modeling and quantitative study of soft contact between abrasive medium and active abrasive particles in abrasive flow machining
Authors: Fan Wulin , Sun Yuli , Liu Chao , Zhao Jianshe , Yang Fanxuan
Published: November 2022

In abrasive flow machining (AFM), material is abraded by active abrasive particles powered by solid-liquid contact between them and the abrasive medium. This contact characteristic is a key and unfortunately it is investigated scarcely.In this work, a soft-contact model was firstly proposed. Soft-contact parameters including protrusion ratio and covering inclination angle were then defined to characterize soft-contact characteristics. Finally, the effect of medium pressure and particle diameter on soft-contact parameters was studied by full factorial design. Results showed that average scratch depth of single active abrasive particle increases with increasing particle diameter and medium pressure. In addition, active abrasive particles are actually deeply wrapped to a large proportion by abrasive medium, and the descriptive protrusion ratio decreases with increasing medium pressure and particle diameter. Moreover, medium pressure offers tangential and normal force for active abrasive particle through a covering inclination angle, and the angle increases with increasing medium pressure and particle diameter. It provides guidance for further improvement of prediction accuracy of material removal in AFM process.
Application of magnetic field assisted finishing process for nanofinishing of freeform femoral knee joint and performance analysis of finished surface
Authors: Barman Anwesa , Das Manas
Published: November 2022

Finishing of femoral knee joint implant is very cumbersome due to its freeform nature. In the present study, a magnetic field-assisted finishing process is employed to uniformly finish the femoral knee implant over its surface curvature at the nanometer level. Experiments are conducted to analyze the freeform surface finishing capability of magnetic field-assisted finishing tool, which proves the tool’s capability to achieve the required surface properties of a femoral knee implant. A comparative analysis between the performance of the magnetic field assisted finishing process and manually polished surface relative to tibial bearing material, that is, ultra-high molecular weight polyethylene with the help of pin-on-disc tribometer, is carried out. It will help to understand the in vivo performance of a finished femoral component of the knee joint by a magnetic field-assisted finishing process. The wear tests prove that the volume loss of the disc material while considering magnetic field-assisted finished pins (11.79 mm3) are better in all cases than the manually polished pins (27.97 mm3). The tribology test also demonstrates that femoral knee implant polished using magnetic field-assisted finishing process will face fewer problems related to wear debris. It will also reduce the problems that occur due to the mixing of debris in the bloodstream. The polishing tool provides almost uniform nanometer-level surface finishing with a standard deviation of 19.23 along the surface curvature. The minimum achieved surface roughness of the femoral knee joint is 20 nm.
Analysis fluid pressure response of hydraulic composite pipe subjected to an axial random vibration
Authors: Qu Wei , Yu Hui , Zhang Huailiang , Li Wei
Published: November 2022

In this paper, the fluid pressure responses of the hydraulic composite pipe subjected to an axial random vibration are investigated. First, the motion equations under an axial random vibration are established, considering the fluid–structure interaction. Second, the characteristic line and the pseudo-excitation methods for random vibration are employed to solve the hydraulic composite pipe dynamic characteristics. Finally, the influence laws of the fluid velocity and pressure, the external excitation, and the structure parameters are analyzed. The results demonstrate that the analytical method is beneficial to analyze the hydraulic composite pipe subjected to an axial random vibration, which can reduce vibration and improve efficiency.
SRM_R: A Web-Based Shiny App for Social Relations Analyses
Authors: Wong Man-Nok , Kenny David A. , Knight Andrew P.
Published: November 2022

Many topics in organizational research involve examining the interpersonal perceptions and behaviors of group members. The resulting data can be analyzed using the social relations model (SRM). This model enables researchers to address several important questions regarding relational phenomena. In the model, variance can be partitioned into group, actor, partner, and relationship; reciprocity can be assessed in terms of individuals and dyads; and predictors at each of these levels can be analyzed. However, analyzing data using the currently available SRM software can be challenging and can deter organizational researchers from using the model. In this article, we provide a “go-to” introduction to SRM analyses and propose SRM_R ( https://davidakenny.shinyapps.io/SRM_R/ ), an accessible and user-friendly, web-based application for SRM analyses. The basic steps of conducting SRM analyses in the app are illustrated with a sample dataset of 47 teams, 228 members, and 884 dyadic observations, using the participants’ ratings of the advice-seeking behavior of their fellow employees.
Otitis media and interna with or without polyps in cats: association between meningeal enhancement on postcontrast MRI, cerebrospinal fluid abnormalities, and clinician treatment choice and outcome
Authors: Dutil Guillaume F , Guevar Julien , Schweizer Daniela , Roosje Petra , Kajin Filip , Volk Holger A , Grapes Nick J , De Decker Steven , Gutierrez-Quintana Rodrigo , Abouzeid Jad , Freeman Paul , Faller Kiterie ME , Stein Veronika M , Maiolini Arianna
Published: November 2022

Objectives

The aim of this study was to evaluate the association between meningeal enhancement (MgE) and cerebrospinal fluid (CSF) analysis results, their individual association with bacteriology results from affected ear samples and whether these test results influenced clinicians’ therapeutic choice in cats with otitis media and interna (OMI).

Methods

This was a multicentre retrospective study carried out over an 8-year period. Cats diagnosed with OMI, with or without a nasopharyngeal polyp, leading to peripheral vestibular signs were included. Only cats for which MRI with postcontrast T1-weighted sequences and CSF analyses available were included. Cats with intra-axial MRI lesions or empyema were excluded.

Results

Fifty-eight cats met the inclusion criteria. MgE was reported in 26/58 cases, of which nine had an abnormal CSF result (increased total nucleated cell count [TNCC] or total protein); 32/58 cases had no MgE, of which 10 showed abnormal CSF results. There was no association between bacteriology results (external ear canal or bulla) and MgE or abnormal CSF results. CSF abnormalities were statistically significantly more common in acute cases (n = 16/37) than in chronic cases (n = 3/21; Fischer’s test P = 0.04). Prednisolone was prescribed in 10/16 cases with increased TNCC. Among the 42 cases with normal TNCC, 15 received prednisolone and 13 received non-steroidal anti-inflammatory drugs. Various antimicrobial drugs were prescribed in 53/58 cats. Duration of antimicrobial treatment was similar, regardless of positive bacterial culture (5.58 vs 4.22 weeks), abnormal CSF (5.83 vs 4.76 weeks) or MgE (5.33 vs 4.90 weeks).

Conclusions and relevance

No association was found between the CSF and MgE results. Furthermore, no association was found between MgE, CSF or bacteriology findings. In addition, abnormal CSF results might lead the clinician to treat with corticosteroids, but they did not have any impact on duration of antimicrobial treatment. CSF abnormalities were seen significantly less frequently in chronic cases. The outcome tended to be poorer when MgE was detected on MRI.
Cardiopulmonary and propofol-sparing effects of dexmedetomidine in total intravenous anesthesia in cats undergoing ovariohysterectomy
Authors: Sanches Mariana C , Bessi Wellington H , Rusch Elidiane , Schaffhausser Marianna B , Cassoli Ana A , Freitas Silvio H , Gehrcke Martielo I , Carregaro Adriano B
Published: November 2022

Objectives

This study aimed to assess the effect of dexmedetomidine on the propofol-based anesthesia of cats subjected to ovariohysterectomy.

Methods

Twenty-eight cats were randomly allocated to four groups (seven cats in each) and premedicated with either 5 µg/kg dexmedetomidine (groups Dex 1, Dex 3 and Dex 5) or 0.05 ml saline (Prop group) intramuscularly. After the induction of anesthesia with propofol, total intravenous anesthesia was initiated with 300 µg/kg/min propofol plus 3 ml/kg/h NaCl 0.9% (Prop), or 200 µg/kg/min propofol plus dexmedetomidine at the rates of 1 µg/kg/h (Dex 1), 3 µg/kg/h (Dex 3) or 5 µg/kg/h (Dex 5). Cardiorespiratory variables were assessed 5 mins after induction and every 10 mins thereafter, until the end of anesthesia. The propofol infusion rate was adjusted every 10 mins (± 50 µg/kg/min) to maintain anesthetic depth. The times to extubation, sternal recumbency, ambulation and total recovery were recorded. Pain scoring was performed 1, 2, 4, 8, 12 and 24 h after the end of anesthesia.

Results

Dexmedetomidine produced a propofol-sparing effect of 72.8%, 71.1% and 74.6% in the Dex 1, Dex 3 and Dex 5 groups, respectively. Cats in the Prop group maintained higher heart rate values than the other groups, and the mean arterial pressure remained higher in the Dex 3 and Dex 5 groups. Rescue intraoperative analgesia (fentanyl bolus) was most frequent in the Prop group. There was no significant difference in the time of extubation. Cats in the Dex 1 and Dex 3 groups had a faster anesthetic recovery, with shorter times to achieving sternal recumbency, regaining ambulation and reaching full recovery. Cats in the Dex 1 and Dex 5 groups presented the best recovery quality scores, with 4 (range 4–5) and 4 (range 3–5), respectively, while the Prop group scored 1 (range 1–3), the worst anesthetic recovery score among the groups.

Conclusions and relevance

The use of dexmedetomidine as a total intravenous anesthesia adjuvant, especially at doses of 1 and 3 µg/kg/h, reduces propofol consumption and improves cardiorespiratory stability and intraoperative analgesia, while promoting a better and quicker recovery from anesthesia.
Dynamic characteristics analysis method of flexible hanger based on Wittrick-Williams algorithm
Authors: Liao Xia , Dan Danhui , Han Fei
Published: November 2022

As important bearing members of the suspension and arch bridges, flexible slings determine the bearing capacity and durability of bridges. Therefore, it is of great significance to study its dynamic characteristics for the design, operation, and maintenance of suspension and arch bridges. In this paper, first, based on the Euler beam model, the dynamic stiffness method (DSM) is used to systematically derive the solving formula of the frequency equation of the sling considering bending stiffness under any boundary conditions. Combined with the Wittrick-Williams (W-W) algorithm, an accurate method for calculating the vibration modal frequency of the sling is proposed, and a set of fine analysis theory suitable for the dynamic characteristics analysis of the sling is formed. Second, the accuracy of the calculation method and analysis theory is verified by the degradation of model parameters, literature method and finite element modeling. Finally, the comparison with the measured data of Mingzhou Bridge shows that the proposed analysis theory is feasible in practical engineering. The theoretical system provides a reference for further study of the dynamic characteristics of the sling and guides the design and monitoring of the actual engineering sling to a certain extent.
Grandparenting relations in advertising’s ‘familial fictions’
Authors: O’Donohoe Stephanie , Gram Malene , Marchant Caroline
Published: November 2022

Since social displays of family life in advertising contribute to the doing and imagining of family, advertising representations of intergenerational relationships merit research attention. Focussing on the under-examined area of family interactions involving grandparents, this content and thematic analysis of 82 North American and European TV/video advertisements highlights how advertising both reproduces and challenges ideals of happy, harmonious families. Consistent with prior research in Western cultures, these ads privilege White, middle-class, heterosexual ways of doing family. Surprisingly, given critiques of advertising idealization, ads depicting intergenerational tension outnumbered those featuring exclusively harmonious relations. Tensions were linked to violations of generational norms, particularly by grandparents, and to conflicting norms confronting different generations. Although gender roles were sometimes blurred in both harmony and tension ads, they were not generally contested by other family members.
C1q/TNF-related protein-2 improved angiogenesis to protect myocardial function during ischaemia‒reperfusion
Authors: Ye Mingfang , Wu Qi-Hong , Yang Ke , Luo Yukun
Published: November 2022

Background

Collateral growth plays an important role in the recovery of acute myocardial infarction. C1q/TNF-related protein-2 (CTRP2), a CTRP family member, showed some protective effects on cell survival. In this study, the relationship between CTRP2 and collateral growth was examined.

Methods

C57BL/6 mice were subjected to myocardial ischaemia/reperfusion (I/R), and the expression of CTRP2 and the effect of CTRP2 on infarction size, cardiac function and angiogenesis were examined. The ischaemic hindlimb model was also used to examine the effect of CTRP2. In vitro, CTRP2-mediated regulation of angiogenesis, AKT activation and VEGFR2 expression in endothelial cells was examined. The CTRP2 level associated with good collateral growth was observed in a cohort.

Results

I/R reduced CTRP2 expression, and intraperitoneal injection of recombinant CTRP2 protein improved infarction size, cardiac function and angiogenesis. Overexpression of CTRP2 promoted blood refusion and collateral growth in ischaemic hindlimb mice. In vitro, CTRP2 enhanced tube formation and migration in a dose-dependent manner, while CTRP2 increased AKT phosphorylation and VEGFR2 expression. In an observational clinical cohort, CTRP2 levels were significantly increased in patients with good collateral growth, and CTRP2 was negatively associated with poor collateral growth in patients.

Conclusion

CTRP2 improved cardiac function by promoting collateral growth by promoting AKT-VEGFR2.
Missing Bullets: Bullet Embolization Case Series and Review of the Literature
Authors: Castater Christine , Noorbakhsh Soroosh , Harousseau William , Klingensmith Nathan , Koganti Deepika , Nguyen Jonathan , Smith Randi N. , Benarroch-Gampel Jaime , Ramos Christopher R. , Rajani Ravi , Sciarretta Jason D.
Published: November 2022

Purpose

Bullet embolization is a rare but dangerous phenomenon. Based on the location of embolization, migration of bullets can cause limb or intra-abdominal ischemia, pulmonary infarction, cardiac valve injury, or cerebrovascular accident. Bullet emboli can present a diagnostic challenge given the varied nature of complications based on location of embolization, which may not coincide with the site of initial injury. The purpose of this study is to present several cases of bullet embolization from our busy urban trauma center and make recommendations for management.

Methods

We present 3 cases of bullet embolization seen in injured patients at our Level 1 trauma center. We describe our management of these injuries and make recommendations for management in the context of our institutional experience and comment on the available literature regarding bullet embolization.

Results

Two of our patients presented in extremis and required operative intervention to achieve stability. The intravascular missile was discovered intraoperatively in one patient and removed in the operating room, while the missile was discovered on postoperative imaging in another patient and again removed operatively after an unsuccessful attempt at minimally invasive retrieval. Our third patient remained hemodynamically stable throughout his hospitalization and had endovascular management of his bullet embolus.

Conclusion

Bullet emboli present a challenging complication of penetrating trauma. We recommend removal of all arterial bullet emboli and those within the pulmonary venous system. In hemodynamically stable patients, we recommend initial attempts of endovascular retrieval followed by open surgical removal. We recommend open removal in cases of hemodynamic instability.
The Ukraine war and the consequences for Germany’s regions: Challenges and opportunities using the example of small and medium-sized businesses
Authors: Wick Lukas , Ayrinhac Adrien
Published: November 2022

This article will take a close look at the state of Germany’s small and medium-sized enterprises, focusing on the companies considered to be the winners and losers in the Ukraine crisis. Proceeding in this way will make it possible to draw some initial conclusions from the current crisis and to link them to the next major problem that the EU will have to face: its dependence on China. Looking at how Germany’s small and medium-sized enterprises are currently faring will help us gauge how the EU’s economic area might be hit should an even more severe crisis occur (e.g. in connection with China). In getting started, a comparison is made with the Covid-19 crisis to clarify the severity of the current crisis and to provide a basis for understanding what is yet to come.
Addressing the consequences of Russian aggression towards Ukraine: The case of affordable housing in Central and Eastern Europe
Authors: Merheim-Eyre Iva
Published: November 2022

As a result of Russian aggression towards Ukraine, lowering European dependence on Russian energy has become a priority for the EU. Policy responses that address energy security have the potential to accelerate the EU’s path to carbon neutrality as well as to boost the funds available for energy efficiency improvements. However, due to the escalating cost of living, many fear energy policy changes may put even more pressure on those who are already struggling to pay their bills. This article argues that for geographic, historical and political reasons, the affordable and social housing sector in Central and Eastern European EU member states is the place to start with the implementation of new energy policy goals. These countries could use funds newly made available to address the needs of Ukrainian refugees while easing the housing problem that this region has been tussling with for decades.
Judging prosecutors: Public support for prosecutorial discretion
Authors: Nelson Michael J. , Samarth Taran
Published: November 2022

Prosecutors have immense discretion to determine which offenses to charge, which cases to take to trial, and which sentences to recommend. Yet, even though many of the prosecutors who exercise this discretion over important crimes must face the electorate to keep their jobs, we know little about how the use of this discretion affects prosecutors’ electoral fortunes. Drawing on two experiments embedded in a nationally representative survey, we demonstrate that the public is more supportive of prosecutors who issue lenient sentences for low-level crimes. The results have important implications for criminal justice reform inasmuch as they provide a linkage between progressive prosecutorial behavior and respondents’ vote intentions.
A Theory of Momentary Distress Tolerance: Toward Understanding Contextually Situated Choices to Engage With or Avoid Distress
Authors: Veilleux Jennifer C.
Published: November 2022

As a transdiagnostic vulnerability factor, low distress tolerance predicts a wide variety of psychopathology. The current article extends past research, which has typically adopted an individual-differences approach, by articulating a social-cognitive theory of momentary distress tolerance. This new model intentionally separates actions taken to remain engaged with distress (i.e., tolerance) from avoidance/escape actions associated with intolerance, and highlights willingness to experience distress as central to tolerance. In addition, self-efficacy for tolerating distress is highlighted as a central predictor of the tolerance/intolerance process, influenced by distress intensity and momentary psychological resources (e.g., hunger, tiredness, degree of life stressors, social support). Finally, the model also explains how repeated experiences of distress tolerance and/or intolerance coalesce into a global self-perception indicative of individual differences in distress tolerance. Reasons why the proposed model has the potential to overcome current challenges in distress tolerance research are reviewed, and future directions for both research and clinical practice are highlighted.
Sports Participation After Reverse Total Shoulder Replacement
Authors: Al Housni Hilal S.A. , Lam Patrick H. , Latif Joseph W. , Murrell George A.C.
Published: November 2022

Background:

Reverse total shoulder replacement (RTSR) is becoming a popular and reliable treatment for rotator cuff arthropathy. However, little is known about the ability to participate in sports after surgery.

Purpose:

To determine to what extent RTSR will allow patients to participate in sporting activities and identify the associated factors that could affect postoperative sports participation.

Study Design:

Case series; Level of evidence, 4.

Methods:

Data were collected prospectively from patients who underwent RTSR over a 10-year period from April 2009 to May 2019. Patients were assessed before surgery, at 6 months after surgery, and at the final follow-up. Patients were asked within a validated shoulder questionnaire to rank their current highest level of sports participation, overall shoulder status, frequency of pain, level of pain, and functional levels. Their shoulder range of motion and strength were assessed before surgery and at 6 months after surgery.

Results:

The study included 108 shoulders (106 patients). The mean age was 74 years (range, 51-88 years), with 44 men and 64 women. The mean follow-up was 4 years. Overall shoulder satisfaction, frequency and levels of pain, and shoulder function improved significantly at 6 months and 4 years ( P < .0001). External rotation, abduction, and forward flexion range of motion improved significantly at 6 months ( P < .05 for all). The strength of internal rotation, external rotation, abduction, and adduction improved significantly at 6 months ( P < .001 for all). The rate of return to sports was 67% at 6 months and 48% at 4 years. Multiple significantly associated factors were identified with return to sports at 6 months, including sex and age.

Conclusion:

The rate of return to sports after RTSR is high. Around two-thirds of patients can return to sports at 6 months postoperatively, although the results slightly deteriorate over time (48% at 4 years).
Postnatal Care Utilization Coverage and its Associated Factors Among Mothers in South Gondar Zone, Northwest Ethiopia: A Cross-Sectional Study
Authors: Fenta Setegn Muche , Moyehodie Yikeber Abebaw , Belay Alebachew Taye , Biresaw Hailegebrael Birhan , Fentaw Kenaw Derebe , Yalew Mequanint Melkam , Muluneh Mitiku Wale , Mulugeta Solomon Sisay , Mekie Maru
Published: November 2022

Background

Postnatal care (PNC) is critical for both the mother and the infant to treat delivery complications and provide the mother with important information on caring for herself and her baby. However, only 17% of women and 13% of newborns in Ethiopia received a postnatal checkup within the first two days of birth. This figure is significantly lower than the least developed countries. This study aimed to assess the coverage and associated factors of PNC service utilization in South Gondar Zone, Northwest Ethiopia.

Method

A community-based cross-sectional study was conducted from September 2020 to May 2021. The data were gathered using an interviewer-administered structured questionnaire. A total of 434 women who gave birth within 2 years of the study were included in the analysis. Bivariable and multivariable logistic regression model was used to identify factors associated with PNC service utilization.

Result

The prevalence of women who used PNC services was 36.4%. The study showed that antenatal care visit, husbands who have a secondary education, women with a secondary education, daily laborer women, husbands working for the government or non-profit sector, delivered in a health institution, nearby hospitals, travel by car to the nearest health facility were positively associated with PNC utilization. While, not having a cell phone, rural women and not having road access to a health facility, have not been receiving counseling were negatively associated with PNC utilization.

Conclusion

The coverage of PNC service utilization in the study area was extremely low. Therefore, government and health care departments should pay special attention to uneducated women, women in rural areas, and women who are unemployed, are not exposed to mass media, and do not have access to transportation to improve PNC service utilization. Furthermore, programs educating mothers on the benefits of antenatal checkups and safer places of childbirth should be considered to increase PNC service utilization.
How Inclusive Leadership Influences Voice Behavior in Construction Project Teams: A Social Identity Perspective
Authors: Jiang Shan , Ma Guofeng , Wang Ding , Jia Jianyao
Published: November 2022

Voice behavior of project team members (PTMs), defined as the process in which PTMs proactively share ideas, concerns, and opinions about work-related issues to improve the status quo of projects, is pivotal but underexplored in construction projects. Using social identity theory, this study investigated how inclusive leadership influences PTMs’ voice behavior with survey data from 232 construction PTMs. The results indicated that inclusive leadership predicts PTMs’ promotive and prohibitive voice behavior, whereas project identification mediates both relationships. Team coordination strengthens such indirect impacts of inclusive leadership on PTMs’ prohibitive voice. Theoretical and practical implications of these empirical findings are discussed.
New arsenate minerals from the Arsenatnaya fumarole, Tolbachik volcano, Kamchatka, Russia. XIX. Axelite, Na14Cu7(AsO4)8F2Cl2
Authors: Pekov Igor V. , Zubkova Natalia V. , Agakhanov Atali A. , Yapaskurt Vasiliy O. , Belakovskiy Dmitry I. , Britvin Sergey N. , Sidorov Evgeny G. , Kutyrev Anton V. , Pushcharovsky Dmitry Yu.
Published: November 2022

The new mineral axelite, ideally Na14Cu7(AsO4)8F2Cl2, was found in the Arsenatnaya fumarole at the Second scoria cone of the Northern Breakthrough of the Great Tolbachik Fissure Eruption, Tolbachik volcano, Kamchatka, Russia. It is associated with sylvite, halite, arsmirandite, bradaczekite, johillerite, tilasite, ericlaxmanite, lammerite, hematite, tenorite, cassiterite, pseudobrookite, aphthitalite-group sulfates, anhydrite, fluoborite, sanidine and fluorophlogopite. Axelite occurs as tabular, quadratic, rectangular or stronger distorted crystals up to 0.02 × 0.1 × 0.1 mm, sometimes combined in interrupted crusts up to 0.4 mm across overgrowing sylvite. It is transparent, sky-blue, with vitreous lustre. Cleavage was not observed. Dcalc is 3.662 g cm–3. Axelite is optically uniaxial (–), ɛ = 1.650(4) and ω = 1.678(4). Chemical composition (wt.%, electron microprobe data) is: Na2O 22.54, K2O 0.08, CaO 0.04, MgO 0.05, CuO 26.69, P2O5 1.75, V2O5 0.15, As2O5 44.14, SO3 0.04, F 1.57, Cl 3.60, –O=(F,Cl) –1.47, total 99.18. The empirical formula based on O+F+Cl=36 apfu is Na14.37K0.03Ca0.01Mg0.02Cu6.63P0.49V0.03As7.59S0.01O32.36F1.63Cl2.01. Axelite is tetragonal, P4bm, a = 14.5957(2), c = 8.34370(18) Å, V = 1777.51(6) Å3 and Z = 2. The strongest reflections of the powder X-ray diffraction (XRD) pattern [d,Å(I)(hkl)] are: 8.32(44)(001), 5.156(47)(220), 4.168(21)(002), 3.246(34)(222), 3.180(61)(331), 2.747(100)(402), 2.709(36)(511) and 2.580(29)(440). The crystal structure, solved from single-crystal XRD data (R = 4.50%), is unique. It is based on the heteropolyhedral chains built by clusters formed by CuO4Cl square pyramids connected with AsO4 tetrahedra. Adjacent chains are connected via common vertices of AsO4 tetrahedra with CuO4Cl pyramids to form a heteropolyhedral pseudo-framework. Axelite is remotely related, in both structural and chemical aspects, to lavendulan-like minerals and synthetic compounds. The mineral is named in honour of the outstanding Finnish–Russian crystallographer, mineralogist and material scientist Axel Gadolin (1828–1892).
Open-label pilot study of romiplostim for thrombocytopenia after autologous hematopoietic cell transplantation
Authors: Scordo Michael , Gilbert Leah J. , Hanley Danielle M. , Flynn Jessica R. , Devlin Sean M. , Nguyen Linh K. , Ruiz Josel D. , Shah Gunjan L. , Sauter Craig S. , Chung David J. , Landau Heather J. , Lahoud Oscar B. , Lin Richard J. , Dahi Parastoo B. , Perales Miguel-Angel , Giralt Sergio A. , Soff Gerald A.
Published: November 2022

There are no standard treatments to prevent or hasten the recovery from severe conditioning-regimen–induced thrombocytopenia occurring after autologous hematopoietic cell transplantation (auto-HCT). We conducted an open-label, single-arm pilot study of romiplostim, a thrombopoietin receptor agonist, to enhance platelet recovery in patients with multiple myeloma or lymphoma undergoing auto-HCT. All patients were treated weekly with romiplostim starting day +1 after auto-HCT until the platelet count was >50 × 109/L without transfusion. Compared with contemporary retrospective data from romiplostim-naïve patients (N = 853), romiplostim-treated patients (N = 59) had a similar median number of days of grade 4 thrombocytopenia or days requiring transfusions, time to platelet engraftment, and number of platelets transfusions during the auto-HCT. However, romiplostim-treated patients had enhanced platelet recovery to normal values beginning at approximately day +15. In matched cohort multivariable analyses, romiplostim treatment was associated with higher platelet counts by an average of 40 × 109/L (95% confidence interval (CI) (14, 67), P = .003) and 118 × 109/L (95% CI [84, 152], P<.001) at days +21 and +30, respectively, compared with those of no romiplostim. Only 1 adverse event was deemed possibly attributable to romiplostim: a low-risk pulmonary embolism in a patient with multiple myeloma. In conclusion, romiplostim showed promising activity and safety after auto-HCT, but the improvement in platelet counts occurred later than the goal of shortening the duration and depth of the platelet nadir. This trial was registered at www.clinicaltrials.gov (#NCT04478123).
Peripheral blood monocyte count is a dynamic prognostic biomarker in multiple myeloma
Authors: Edwards Camille V. , Hassan Hamza , Yildirim Cenk , Ferri Grace , Verma Karina P. , Murray Horwitz Mara E. , Fillmore Nathanael R. , Munshi Nikhil C.
Published: November 2022

With the growing knowledge of multiple myeloma (MM) pathobiology and the introduction of novel therapies, risk stratification continues to evolve. Myeloid-derived suppressor cells and tumor-associated macrophages, derived from peripheral blood monocytes, support malignant plasma cell proliferation in the bone marrow. Because peripheral blood absolute monocyte count (AMC) is thought to reflect the bone marrow microenvironment, we sought to evaluate the prognostic significance of AMC in MM. We retrospectively analyzed 10 822 patients newly diagnosed with MM between 2000 and 2019 at Veteran’s Administration hospitals. We obtained AMC closest to diagnosis and every 3 months thereafter up to 2.5 years. Patients were stratified into 4 groups: low, normal, elevated, and severely elevated AMC (<0.2, 0.2-<0.8, 0.8-<1.25, and ≥1.25 × 103/mm3, respectively). Abnormal AMC at diagnosis was observed in 25.3% of the patients and was associated with an inferior overall survival (OS). In patients with low, severely elevated, elevated, and normal AMC, respectively, median OS at diagnosis was 2.3, 2.7, 3.1, and 3.6 years (P < .001) and at 2.5 years was 2.0, 2.6, 3.4, and 3.9 years (P < .001). Patients with normal AMC at diagnosis who developed an abnormal AMC >1 year after diagnosis also had an inferior OS relative to patients who maintained a normal AMC. Abnormal AMC was also associated with inferior OS independent of validated prognostic markers, including the international staging system and lactate dehydrogenase. Our findings provide novel clues for future prospective studies on the functional role of monocytes in MM, which could be a readily available metric for risk stratification.
Fabrication of Ordered Micro/Nanostructures Using Probe-Based Force-Controlled Micromachining System
Authors: Geng Yanquan , Wang Yuzhang , Cai Jianxiong , Zhang Jingran , Yan Yongda
Published: November 2022

This paper presents a probe-based force-controlled nanoindentation method to fabricate ordered micro/nanostructures. Both the experimental and finite element simulation approaches are employed to investigate the influence of the interval between the adjacent indentations and the rotation angle of the probe on the formed micro/nanostructures. The non-contacting part between indenter and the sample material and the height of the material pile-up are two competing factors to determine the depth relationship between the adjacent indentations. For the one array indentations, nanostructures with good depth consistency and periodicity can be formed after the depth of the indentation becoming stable, and the variation of the rotation angle results in the large difference between the morphology of the formed nanostructures at the bottom of the one array indentation. In addition, for the indentation arrays, the nanostructures with good consistency and periodicity of the shape and depth can be generated with the spacing greater than 1 μm. Finally, Raman tests are also carried out based on the obtained ordered micro/nanostructures with Rhodamine probe molecule. The indentation arrays with a smaller spacing lead to better the enhancement effect of the substrate, which has the potential applications in the fields of biological or chemical molecular detection.
Fuel and material utilization of a waste shiitake (Lentinula edodes) mushroom bed derived from hardwood chips II thermal conductivity of compression-dried waste mushroom beds
Authors: Jiang Zhuoqiu , Sekino Noboru
Published: November 2022

This study investigated using waste mushroom beds as insulation material and applied compression-drying to eliminate the coarse voids that are unfavorable for insulation. The relationship between air-dry density and thermal conductivity was investigated. The mean air-dry density of the uncompacted waste mushroom beds was approximately 200 kg/m3, which increased to approximately 550 kg/m3 after four levels of compression-drying. A linear relationship was recognized between the air-dry density and thermal conductivity of the waste mushroom bed. Comparing this relationship to those of wood and mat-formed wood-based panels showed that the thermal conductivity of a waste mushroom bed is similar to that of wood at low densities and mat-formed wood-based panels at high densities. Furthermore, the thermal conductivity of heat bridges was estimated using a series–parallel heat-flow model for voids and substances, and the substance thermal conductivity was in the order of wood (0.218 W/mK), waste mushroom bed (0.288 W/mK), and mycelium (0.368 W/mK). The same heat-flow model was applied to a waste mushroom bed to obtain the substance thermal conductivity along the heat-flow direction. The results show that the waste mushroom bed substance also has an anisotropic thermal conductivity.
An Enzyme-Free Sandwich Amperometry-Type Immunosensor Based on Au/Pt Nanoparticle-Functionalized Graphene for the Rapid Detection of Avian Influenza Virus H9 Subtype
Authors: Huang Jiaoling , Xie Zhixun , Li Meng , Luo Sisi , Deng Xianwen , Xie Liji , Fan Qing , Zeng Tingting , Zhang Yanfang , Zhang Minxiu , Wang Sheng , Xie Zhiqin , Li Dan
Published: November 2022

Avian influenza virus H9 subtype (AIV H9) has contributed to enormous economic losses. Effective diagnosis is key to controlling the spread of AIV H9. In this study, a nonenzymatic highly electrocatalytic material was prepared using chitosan (Chi)-modified graphene sheet (GS)-functionalized Au/Pt nanoparticles (GS-Chi-Au/Pt), followed by the construction of a novel enzyme-free sandwich electrochemical immunosensor for the detection of AIV H9 using GS-Chi-Au/Pt and graphene–chitosan (GS-Chi) nanocomposites as a nonenzymatic highly electrocatalytic material and a substrate material to immobilize capture antibodies (avian influenza virus H9-monoclonal antibody, AIV H9/MAb), respectively. GS, which has a large specific surface area and many accessible active sites, permitted multiple Au/Pt nanoparticles to be attached to its surface, resulting in substantially improved conductivity and catalytic ability. Au/Pt nanoparticles can provide modified active sites for avian influenza virus H9-polyclonal antibody (AIV H9/PAb) immobilization as signal labels. Upon establishing the electrocatalytic activity of Au/Pt nanoparticles on graphene towards hydrogen peroxide (H2O2) reduction for signal amplification and optimizing the experimental parameters, we developed an AIV H9 electrochemical immunosensor, which showed a wide linear range from 101.37 EID50 mL−1 to 106.37 EID50 mL−1 and a detection limit of 100.82 EID50 mL−1. This sandwich electrochemical immunosensor also exhibited high selectivity, reproducibility and stability.
Identification of crucial genes and metabolites regulating the eggshell brownness in chicken
Authors: Yang Jing , Mao Zhiqiong , Wang Xiqiong , Zhuang Jingjie , Gong Sijia , Gao Zhouyang , Xu Guiyun , Yang Ning , Sun Congjiao
Published: November 2022

Background

Protoporphyrin IX (Pp IX) is the primary pigment for brown eggshells. However, the regulatory mechanisms directing Pp IX synthesis, transport, and genetic regulation during eggshell calcification in chickens remain obscure. In this study, we investigated the mechanism of brown eggshell formation at different times following oviposition, using White Leghorn hens (WS group), Rhode Island Red light brown eggshell line hens (LBS group) and Rhode Island Red dark brown eggshell line hens (DBS group).

Results

At 4, 16 and 22 h following oviposition, Pp IX concentrations in LBS and DBS groups were significantly higher in shell glands than in liver (P < 0.05). Pp IX concentrations in shell glands of LBS and DBS groups at 16 and 22 h following oviposition were significantly higher than WS group (P < 0.05). In comparative transcriptome analysis, δ-aminolevulinate synthase 1 (ALAS1), solute carrier family 25 member 38 (SLC25A38), ATP binding cassette subfamily G member 2 (ABCG2) and feline leukemia virus subgroup C cellular receptor 1 (FLVCR1), which were associated with Pp IX synthesis, were identified as differentially expressed genes (DEGs). RT-qPCR results showed that the expression level of ALAS1 in shell glands was significantly higher in DBS group than in WS group at 16 and 22 h following oviposition (P < 0.05). In addition, four single nucleotide polymorphisms (SNPs) in ALAS1 gene that were significantly associated with eggshell brownness were identified. By identifying the differential metabolites in LBS and DBS groups, we found 11-hydroxy-E4-neuroprostane in shell glands and 15-dehydro-prostaglandin E1(1-) and prostaglandin G2 2-glyceryl ester in uterine fluid were related to eggshell pigment secretion.

Conclusions

In this study, the regulatory mechanisms of eggshell brownness were studied comprehensively by different eggshell color and time following oviposition. Results show that Pp IX is synthesized de novo and stored in shell gland, and ALAS1 is a key gene regulating Pp IX synthesis in the shell gland. We found three transporters in Pp IX pathway and three metabolites in shell glands and uterine fluid that may influence eggshell browning.
Patient and hospital characteristics predict prolonged emergency department length of stay and in-hospital mortality: a nationwide analysis in Korea
Authors: Lee Kyung-Shin , Min Hye Sook , Moon Jae Young , Lim Daesung , Kim Younghwan , Ko Eunsil , Kim You Sun , Kim Joohae , Lee Jeehye , Sung Ho Kyung
Published: November 2022

Background

Prolonged emergency department length of stay (EDLOS) in critically ill patients leads to increased mortality. This nationwide study investigated patient and hospital characteristics associated with prolonged EDLOS and in-hospital mortality in adult patients admitted from the emergency department (ED) to the intensive care unit (ICU).

Methods

We conducted a retrospective cohort study using data from the National Emergency Department Information System. Prolonged EDLOS was defined as an EDLOS of ≥ 6 h. We constructed multivariate logistic regression models of patient and hospital variables as predictors of prolonged EDLOS and in-hospital mortality.

Results

Between 2016 and 2019, 657,622 adult patients were admitted to the ICU from the ED, representing 2.4% of all ED presentations. The median EDLOS of the overall study population was 3.3 h (interquartile range, 1.9–6.1 h) and 25.3% of patients had a prolonged EDLOS. Patient characteristics associated with prolonged EDLOS included night-time ED presentation and Charlson comorbidity index (CCI) score of 1 or higher. Hospital characteristics associated with prolonged EDLOS included a greater number of staffed beds and a higher ED level. Prolonged EDLOS was associated with in-hospital mortality after adjustment for selected confounders (adjusted odds ratio: 1.18, 95% confidence interval: 1.16–1.20). Patient characteristics associated with in-hospital mortality included age ≥ 65 years, transferred-in, artificially ventilated in the ED, assignment of initial triage to more urgency, and CCI score of 1 or higher. Hospital characteristics associated with in-hospital mortality included a lesser number of staffed beds and a lower ED level.

Conclusions

In this nationwide study, 25.3% of adult patients admitted to the ICU from the ED had a prolonged EDLOS, which in turn was significantly associated with an increased in-hospital mortality risk. Hospital characteristics, including the number of staffed beds and the ED level, were associated with prolonged EDLOS and in-hospital mortality.