bluuebunny/crossref_metadata_2025 huggingface dataset:
Penerapan Model Problem Based Learning Teknik Probing Prompting terhadap Pemahaman Konsep Fisika
Authors: Kalsum Ummu , Humairah Nur Aisyah , Sabaruddin Misbah
Published: July 2022

Penelitian bertujuan untuk mengetahui kemampuan pemahaman konsep fisika siswa sebelum dan setelah diterapkan model  pembelajaran Problem Based Learning (PBL) menggunakan teknik Probing Prompting serta untuk mengetahui perbedaan yang signifikan kemampuan pemahaman konsep fisika siswa sebelum dan setelah diterapkan model pembelajaran PBL menggunakan teknik Probing Prompting. Jenis penelitian adalah Pra – Eksperimen menggunakan One Group Pretest – Posttest Desaign. Populasi penelitian yaitu seluruh siswa kelas XII MIA SMA Negeri 2 Majene dengan sampel penelitian adalah XII MIA yang berjumlah 25 orang. Sampel penelitian diperoleh dengan teknik purposive sampling. Teknik pengumpulan data dalam penelitian menggunakan instrumen keterlaksanaan rencana pelaksanaan pembelajaran untuk penilaian model pembelajaran dan tes pilihan ganda beralasan untuk pemahaman konsep fisika siswa. Teknik analisis data menggunakan analisis deskriptif untuk penilaian model pembelajaran, hasil penialain pemahaman konsep siswa dan analisis inferensial untuk hasil penilaian pemahaman konsep siswa. Berdasarkan hasil analisis data dapat disimpulkan bahwa kemampuan pemahaman konsep fisika siswa sebelum diterapkan model  PBL menggunakan teknik Probing Prompting tergolong masih sangat rendah, kemampuan pemahaman konsep fisika siswa setelah diterapkan model  pembelajaran PBL menggunakan teknik Probing Prompting tergolong tinggi dan terdapat perbedaan yang signifikan kemampuan pemahaman konsep fisika siswa sebelum dan setelah diterapkan model pembelajaran PBL menggunakan teknik Probing Prompting.
Pengaruh Kebiasaan Merokok dalam Ruangan terhadap Kejadian Pneumonia pada Balita
Authors: Darmansyah Safriadi
Published: July 2022

Penelitian ini bertujuan untuk mengetahui pengaruh kebiasaan merokok orang tua (Ayah) terhadap kejadian pneumonia pada balita. Penelitian ini menggunakan rancangan case control dengan pendekatan retrospektif , sampelnya adalah balita berumur satu bulan sampai lima tahun yang berkunjung di Puskesmas Tappalang Kabupaten Mamuju bulan Januari sampai Mei 2019. Hasil penelitian didapatkan dari 116 keluarga yang menjadi responden ada 77 keluarga yang memiliki kebiasaan merokok dalam ruangan yaitu 33 Ayah merokok kurang dari 10 batang setiap hari dan 46 Ayah merokok  lebih dari 10 batang setiap hari, dan sisanya 39 keluarga tidak merokok dalam ruangan. Sedangkan dari 58 Kejadian pneumonia didapatkan ada 35 orang balita menderita pneumonia dan 23 orang yang menderita pneumonia berat. Selanjutnya data di uji dengan Korelasi Rank Spearman dan didapatkan hasil bahwa ada pengaruh kuat antara kebiasaan merokok ayah dalam ruangan rumah terhadap kejadian pneumonia di wilayah kerja Puskesmas Tappalang.
Simultaneous Localization of a Hydatid Cyst in the Gluteal and Psoas Muscles: A Case Report and Review of the Literature
Authors: Benakrout Aziz , Bouzroud Mohamed , Jalal Youssef , Khallikane Said , Aissa Ismail , Baite Abdelouahed
Published: July 2022

The simultaneous double localization of hydatid cysts in the psoas and gluteal muscles is exceptional. The purpose of this case report is to describe a hydatid cyst located in the left gluteal and psoas muscle in a 28-year-old patient. Ultrasound, CT scan and a positive hydatid serology contributed to the preoperative diagnosis. The patient was operated in two stages. The evolution was good without recurrence after the surgical treatment.
Outcome and Evaluation of Intestinal Obstruction Due to Bands in Virgin Abdomen: A Prospective Study
Authors: Sardar Dr. Md. Aslam Uddin , Alam Dr. Md. Sofiul , Misu Dr. Zakir Hossain
Published: July 2022

Introduction: Some major hospitals and clinics still insist on exploratory surgery when they evaluate a case of Intestinal obstruction in a patient with an otherwise virgin abdomen. Objective: The purpose of this research is to identify the causes of SBO in people who have never performed abdominal surgery. Materials and Methods: Multicentered based nonrandomized quasi experimental prospective study was performed in Northern International Medical College, Dhaka, Bangladesh from January 2018 to December 2021.Total number of patients n=60 treated for Intestinal obstruction due to bands in virgin abdomen. Follow up data, operative and pathologic findings were examined to determine the etiology of SBO. Results: Sixty patients met inclusion criteria; abdominal exploration was performed in 50 patients (83%) and 10 patients (17%) were managed non-operatively. Exploration was therapeutic in 29 (58%), negative in 20 (40%) and non-therapeutic in one patient (2%). Overall, 8 patients (13%) were diagnosed with a malignancy: right-sided colon cancer (n=3), small bowel (SB) neuroendocrine tumor (n=2), SB lymphoma (n=2) and carcinomatosis peritonei (n=1); six patients were diagnosed at the time of the initial exploration and two patients were diagnosed during follow up. Upon Prospective Study, both SB neuroendocrine tumors and one SB lymphoma were visible on the initial imaging. Leukocytosis (p=.03) and no recent weight loss (p=.04) were associated with negative exploration. Conclusion: Patients with a "virgin abdomen" generally have a non-threatening form of Intestinal obstruction in its earliest stages. Careful evaluation of imaging investigations is required for spotting early warning symptoms of a more serious illness. If the patient prefers non-surgical treatment, they will need to have a recent colonoscopy and give relevant examination findings history.
Children with Disability and Education Accessibility in Western Uganda
Authors: Godwin Tumuhairwe
Published: July 2022

This logical study examined the relationship between physical disability and education accessibility in Bushenyi district, in Western Uganda. The organized study used a correlational research design with mixed methods (qualitative and quantitative approaches). A sample of 108 participants out of 150 accessible population was chosen utilizing a table developed by (Morgan & Kreijcie, 1970). Data was collected employing scholar generated questionnaires and interview guides and summarized using Descriptive dimensions and Pearson Product Moment Correlation Coefficient for quantitative analysis and thematic analysis was employed for amalgamating qualitative issues .The inquiry study results came up with a significant relationship between physical disability and education accessibility in Bushenyi in Western Uganda . It was therefore established that issues related with availability of teachers, required completion rates, retention at school of children with physical disability, and their regular school attendance are critical to children’s accessibility to education in Western Uganda. The study recommended that appropriate mechanisms should be adopted to increase availability of teachers, foster completion rates, school attendance and retention at school for children with physical disability so as to enhance children’s accessibility to education.
Prevalence of Isoniazid Resistance in Mycobacterium tuberculosis in Western Rajasthan
Authors: Bhooshan Suneel , Khatri Dr. P. K.
Published: July 2022

Drug resistance in MTB is alarming because of the limited choice of drugs available for treatment. First line drugs are safe, effective and cheaper than second line drugs. Any resistance in rifampicin or isoniazid will increase the chances of sensitive MTB strain to shift toward MDR or Pre-XDR strains. The male population (70.80%) was more frequently involved than the females (29.2%). The rural population was exposed at higher proportion accounted for 69.8% of cases. Comorbidity tobacco and alcohol consumption was associated in 31.2% and 25.8% of tuberculosis cases. In our study mono resistance in isoniazid was 14.20% which was higher than mono rifampicin resistance of 9.20%. Our findings suggest high resistance to isoniazid alone is alarming as these strains may shift towards MDR, Pre-XDR or XDR strains therefore, furthermore studies should be conducted at a large scale at the community level to estimate the prevalence and prevent this shift of resistant strains.
Intra-Abdominal Desmoid Tumor: A Case Report
Authors: Kadri N. , Darfaoui M. , Mahrouche B. , Rody S. Kandry , Omrani A. El , Khouchani M.
Published: July 2022

A 35 years old female patient, with no particular pathological history, presented for three months with an abdominal mass that was progressively increasing in volume, painful without vomiting or transit disorder. The clinical examination revealed a mass in the right iliac fossa, painful to palpation, round and mobile without inflammatory signs, measuring 50*40mm, with no palpable enlarged lymph nodes. The abdominal CT scan showed an anterior abdominal mass lateralized to the right side, localized in the right internal oblique muscle, measuring 73*54*86 mm, associated with right external iliac lymph nodes measuring up to 8 mm with a low peritoneal effusion of the pouch of Douglas. A biopsy was performed and the histological and immunohistochemical study was positive for desmoid tumor. The patient was treated by wide tumor resection, and put on medical treatment: Tamoxifen-based hormone therapy (20mg/day) with regular monitoring by abdominal CT scan every six months. The evolution was favorable, with no recurrence after 23 months of follow up.
Central Venous Catheter Malposition into the Left Internal Mammary Vein in Patient with Coagulation Disorder and Safe Removal: A Case Report
Authors: Park Dr. Jeong Jun , Kang Dr. Joon Gwon , Lee Dr. Dongreul , Hwang Dr. He Won , Han Dr. Jung Youn
Published: July 2022

A 61-year-old male patient with underlying diseases of hypertension and alcoholic liver cirrhosis was hospitalized for liver transplantation due to advanced liver cirrhosis. In preparation for liver transplant surgery, a multi-lumen access catheter and Swan-ganz catheter are inserted into the right internal jugular vein. And another central venous catheter is inserted into the subclavian vein for central venous pressure measurement and drug administration. There was no abnormal resistance of the guide wire or catheter that the operator could feel during the insertion process, and there was no abnormality in the function of the catheter. But the postoperative chest image showed that the left subclavian central vein catheter was malpositioned. Through venography at the angiography room, it was confirmed that the central venous catheter was inserted into the left internal mammary vein. Since the patient with coagulation disorder, special attention was required to remove the catheter. In addition, due to the location of the internal mammary vein, it was expected that it would be difficult to compress for hemostasis after removal of the catheter. Therefore, it was necessary to check the patient's coagulation test to determine the appropriate time of the catheter removal and cooperation of the radiologist.
Condyloma Acuminata in Children: A Case Report
Authors: Moussaid Zainab , Zaidane Israa , Mekkaoui Nour , Dakhama Badr Sououd Benjelloun , Karboubi Lamya
Published: July 2022

The acuminate condyloma or rooster crest is a benign sexually transmitted infection caused by human papilloma virus. It is common among sexually active adults and adolescents. His discovery in children raises two problems: identifying the mode of transmission so as not to miss a possible sexual abuse and opt for an appropriate therapeutic choice. We report a case of genital condyloma for a 2,5 old girl with no known risk factors for immunosuppression. We discuss the main epidemiological, diagnostic, therapeutic and evolutionary aspects of this condition in children.
Yield Response and Barley Grain Quality to Nitrogen Fertilization in West Arsi Highland of Ethiopia
Authors: Jemal Kedir
Published: July 2022

The malting industry in Ethiopia is often challenged by the availability of barley that meets the quality and quantity requirements set by the industry. Field experiments were conducted to evaluate the effects of mineral nitrogen fertilizer rates on Actual yield and quality response of malt barley varieties and, to determine economic optimum rates of nitrogen fertilizer for the productivity of the crop arranged in randomized complete block design in factorial arrangement with three replications. The treatments are three malt barley varieties, namely Traveler, Ibon and Local and four levels of N (0 kg N/ha, 50 kg N/ha, 100 kg N/ha and 150 kg N/ha. The study revealed that nitrogen fertilization with 150 kg ha-1nitrogen fertilizer rate improved barley yield and quality than the rest nitrogen fertilizer rates. The different barley varieties and nitrogen fertilizer has shown a highly significant (p<0.01) influence on barley yield production. On the other hand, interaction effect of barley varieties and nitrogen fertilizer didn’t show significant variation barley yield production. Moreover, the analysis of variance also revealed that barley varieties have shown a highly significant (p<0.01) influence on barley yield production. The maximum and minimum interaction mean values of actual grain yield were observed from traveler barley variety treated with 150 kg ha-1nitrogen fertilizer rate (2078.10 kg/ha) and Ibon barley variety treated with 0 kg ha-1nitrogen fertilizer rate (1136.30 kg/ha), respectively. In the present investigation, quality parameters increased with an increase in N rates, application of 150 kg N ha-1 gave the highest quality parameters studied except sieve test. While, the quality parameters was less pronounced with the tested varieties and their interaction effect. The partial budget analysis revealed maximum net benefit of (Birr 39147 ha-1) with an acceptable marginal rate of returns (MRR) of 1007.33% with the treatment traveler variety with combination of 150 kg N ha-1. However, the lowest net benefit of (Birr 22726.00 ha-1) was recorded from Ibon barley variety treated with 0 kg ha-1nitrogen fertilizer rate. Both grain yield and protein content increased with increased N rates application of 150kg N ha-1 gave the highest net benefit and marginal rate of return with acceptable grain quality (protein content < 9-12%). Therefore, production of traveler variety with a combination of 150 kg N ha-1 was economical, and uncertainly recommended for production of malt barley in the study area.
A Reflection of Advertisements as an Engine of Change in Behavior and Lifestyle during Covid Period
Authors: Marisha Narula , Rohita Sharma
Published: July 2022

The scourge of coronavirus has jolted every nation directly or indirectly. Macro level effects were seen as economies plunged with many countries reporting negative growth rates. To tackle this storm, countries across the globe went full ballistic to spread information and bits of coronavirus to its citizens. Information was bombarded via every source that was available in the arsenal be it social media, print advertisement, Tv advertisement and radio. Some things were made compulsory, some were told to modify and some to be completely discarded. India was no different. Here too the government imposed lockdowns and traveling restrictions leaving its citizens no choice but to stay home and simply wait it out. Continuous influx of information from all sides created a new norm for society. Suddenly wearing masks was within my comfort zone and multiple hand washing was not annoying anymore. There was a change in behavior patterns as well. Social distancing became the new norm and people accepted it eventually. All these changes were possible because of the sheer number of advertisements people were subjected to. These advertisements created a new normal. There are so many examples in the past of how advertising has changed our attitude, behavior, lifestyle, likes and dislikes. This paper analyzes in depth synthesis of how advertisement not only creates a market for itself but in a way changed our perception and lifestyle in turn to create new norms.
Study of CD117 Expression on Phyllodes Tumor of Breast and Its Correlation with Histopathological Grade
Authors: Shaheen Dr. Nazma , Jeba Dr. Ruksana , Ripon Dr. Mohammad Razaul Karim , Afrin Syeda Sadia , Qurani Dr. Md. Oyes , Saha Dr. Mridul Kumar , Khan Dr. Abu Anis
Published: July 2022

Background: Accurately predicting the nature and differentiating of various grades of Phyllodes tumor, the diagnosis may vary by different pathologists1, as there is no standard interpretation of the histologic cut-point criteria and therefore. In this study, we evaluated the impact of CD117 expression on Phyllodes tumor of breast and usefulness of this marker to differentiating benign from malignant phyllodes tumors. Methods: This cross-sectional observational study was conducted in the Department of Pathology, Dhaka Medical College. The study includes mastectomy/lumpectomy specimens received from surgery and surgical oncology departments and diagnosed as phyllodes tumor histopathological. Tissue processing and staining were performed using standard protocol. Histopathological typing and grading were done according to WHO recommended criteria 2012. Immunostaining for CD117 done on all 50 cases. Toluidine blue staining was performed on CD117 immunostaining positive cases, to see presence of mast cells. Result: This study consists of 50 cases of phyllodes tumor of breast. In all the cases immunohistochemistry was done with markers CD117. Histological Grading of phyllodes tumor was done using stromal cellularity, nuclear pleomorphic, stromal overgrowth, mitotic rate, margin of tumor. Statistical analysis was done and results were compared with various available previous studies. This study showed that most of benign/low grade phyllodes tumors belonged to the age group of 35-46 years and most of malignant phyllodes tumors belonged to the age group of 30.50-47.50 malignant phyllodes tumor in this study was 40 years. Overall 44% (22 out of 50) of the cases showed positivity for CD117 in the stroma. Among them 85% cases of malignant Phyllodes tumors of breast shows stromal expression of CD117. This study shows association of CD117 expression with malignant phyllodes tumor. Epithelial CD117 positivity was found in 69.5% cases of benign/low grade Phyllodes tumors of breast. Current study also shows association of CD117 epithelial expression with benign phyllodes tumor the result of our study show strong correlation between CD117 expression and histopathological grade. Conclusion: In conclusion, we can report an association of CD117 protein expression in borderline/malignant tumors and which may be associated with worse prognosis. So we can suggest for targeted therapy for these patient group having Phyllodes Tumor with positive CD117 expression.
In –Silico Approach for Assessment of Antimicrobial Potential of some Pyrazolidine-3, 5-Dione Derivatives
Authors: Yadav Reena , Malik Jitender K
Published: July 2022

Background: Resistance to antibacterial drugs is a trouble in the worldwide public health that must be conquered immediately by finding new antibacterial drugs.Pyrazolidine-3, 5-dione derivatives of heterocyclic compounds were used as active agents against pathogenic microorganisms. This study has been carried out to rationally design three synthesized derivatives was assayed for antimicrobial potential by using in-silico molecular docking approach. Methods: Molecular docking of Isoleucyl-transfer RNA (tRNA) synthetase (IleRS) with three Pyrazolidine-3, 5-dione synthesized derivatives was carried out by AutoDock. Result: The molecular docking result revealed that synthesized compound 5(a-c) showed encouraging docking score as compared to standard ligand Gentamicin. The docking score found to be - 8.23, - 8.63, -6.89 &-8.30 kcal mol–1 respectively.
Self-Potential; Thinking Style, Emotional Response, and Communication Patterns for New Students at the University of Lampung (UNILA) in 2021
Authors: Nurwahidin Muhammad , Pratama Moch Johan
Published: July 2022

The purpose of this study is (1) to analyze how the type of thinking style of UNILA new students in 2021. (2) to analyze how the type of emotional response of UNILA freshmen in 2021. (3) to analyze the types of communication patterns of UNILA new students in 2021. Research this was carried out simultaneously with the moment of orientation for new students at the University of Lampung in 2021. Descriptive quantitative research methods were used in this study. The subjects in this study were 5,065 new UNILA students in 2021. The survey method was used in this study. The data were analyzed using descriptive qualitative analysis using the SPSS version 22 application tool. The researcher found that (1) the majority of new students (43.3%) had a reflection type of thinking style. (2) the majority of new students (38.7%) had emotional response pattern with empathic type. (3) the majority of new students (43.4%) have a patterned communication pattern.
Analysis of Talents and Career Interests of New Students at the University of Lampung in 2021
Authors: Nurwahidin Muhammad , Pratama Moch Johan
Published: July 2022

The aims of this study are (1) to analyze the talents of new students according to the characteristics of the job description in the creative profession, practitioner profession, academic profession, and entrepreneurial profession and (2) to analyze whether the new students match their talents and interests with their careers. What he wanted. This research was carried out simultaneously with the moment of orientation for new students at the University of Lampung in 2021. Descriptive quantitative research methods were used in this study. The subjects in this study were 5,065 new UNILA students in 2021. The survey method was used in this study. The data were analyzed using descriptive qualitative analysis using the SPSS version 22 application tool. The researcher found that (1) The majority of new students (43.3%) had talents that matched the characteristics of the job description in the creative work profession, 26% had talent as a profession. practitioners, 18.4% have talent as an academic profession, and 12.0% have talent as an entrepreneurial profession. (2) The majority of new students (71.8%) do not match their talents and interests with the career they want. Meanwhile, 28.2% of new students are in an ideal condition where the talents and interests of students are in line with the career they want.
Dynamics of Maritime Trade along the Fako Coastal Belt of Cameroon: Ambiance, Challenges and Sustainable Combat Strategies
Authors: Diang Tufoin Kilian , iafack Ojuku T , Padison Nnecdem
Published: July 2022

Maritime trade is dynamic and indispensable for economic growth and development around the World. This trade if not well monitored can become a threat to development considering the illicit and criminal transactions that surrounds the sector. In Cameroon, this informal trade has degraded customs income and promoted the infiltration of contraband goods into the country via local anchorage sites where custom services are weak. This trade has affected the State pricing policy of certain goods especially fuel. It is against this background that this study sets out to investigate, seaborne trade, and the illegal transactions that are common along the Fako coastal belt of Cameroon. Data for the study have been gathered from secondary and primary sources. Secondary data were gleaned from soft and hard copies of both published and unpublished documents, newspapers, and decrees relevant to maritime transport and trade. Primary data were sourced from field surveys where a simple random sampling technique was used to administer 278 copies of questionnaires to 10 localities along the Fako coastal belt of Cameroon using a convenient sample size. Supplementary primary data was gotten via interviews and observations in the three seaports along the coast. Results revealed that the Limbe, Tiko and Idenau ports though secondary, handles thousands of tonnes of cargo annually making Fako Division where they are located in Cameroon an eminent trading hub. Statistics from the Limbe Port Authority (PAL) indicated an increasing trend of export and imports annually in thousands of tonnes. The results shows that illicit seaborne trade is very common along this coastal belt with over 67 percent of the goods coming in from neighbouring Nigeria. The illicit product identified are petroleum products (46.2%), pharmaceutical products (30 %), food items (16.7%) and chemical fertilizers and others (5.3% and 3.8%) respectively. The results also revealed that in the year 2021 between January and August, over 18 cases of illicit goods were intercepted along this coastline with petroleum products destined to Limbe, Tiko and Idenau ports dominating. The reasons for the persistency of this illicit trade were corruption and the existence of a network of illegal organisation that transact the goods. This study recommends that custom and naval services be reinforced along this coastal belt to ascertain the type and originality of the products entering the country via the sea. Also, the State should investigate and dismantle illicit and organised illegal seaborne trade chains and charge officials at the maritime frontiers to be responsible and corruption free.
Gangguan Penghidu dan Gangguan Pengecapan pada Kasus COVID 19
Authors: Iriani Desy , Mailasari Kusuma Dewi Anna , Hariyati Riece , Iman Santosa Yanuar
Published: July 2022

LATAR BELAKANG : Anosmia adalah hilangnya kemampuan penghidu, hiposmia adalah berkurangnya kemampuan penghidu sedangkan ageusia adalah hilangnya pengecapan. Pasca infeksi virus (common cold) memang sudah dikenal sebagai salah satu penyebab anosmia/hiposmia. Sel epitel pernapasan di hidung dan sel epitel penyokong olfaktori mengekspresikan banyak protein ACE2 yang merupakan reseptor virus SARS-Cov2 untuk menginfeksi sel. Beberapa penelitian menunjukkan meningkatnya kasus disfungsi olfaktori dan gustatori pada pasien COVID-19 dan umumnya merupakan kasus ringan, bahkan ada beberapa kasus COVID-19 tanpa gejala apapun kecuali anosmia. Masa pemulihan anosmia pada COVID 19 yaitu sebelum 2 minggu, namun beberapa kasus dilaporkan terjadi anosmia memanjang, hiposmia ataupun parosmia pasca COVID 19. Penelitian lanjut masih dibutuhkan untuk menambah bukti sebagai bahan pertimbangan mempelajari pola gangguan olfaktori dan gustatori, penyembuhan, tatalaksana dan prognosisnya

 

TUJUAN : Mengetahui prevalensi keluhan anosmia dan atau hiposmia dengan atau tanpa ageusia pada subyek yang terkonfirmasi positif COVID 19 dengan pemeriksaan swab PCR. 

METODE : Penelitian observasional pada 189 subyek yang terkonfirmasi positif COVID-19 dengan pemeriksaan swab PCR tanpa gejala atau gejala ringan yang memenuhi kriteria inklusi di RSUP Dr.Kariadi Semarang. Pada penelitian ini, sampel diberikan kuesioner. Data dianalisis dengan uji chi Square.

HASIL : Prevalensi gangguan olfaktori dan gustatori pada pada subyek yang terkonfirmasi positif COVID 19 dengan pemeriksaan swab PCR tanpa gejala atau gejala ringan yaitu 61% (115 orang), keluhan kebanyakan sembuh dalam 5-8 hari 32% (37 orang), tanpa ada keluhan lain yang berarti.

KESIMPULAN : Prevalensi gangguan olfaktori dan gustatori cukup tinggi sehingga temuan gejala ini merupakan gejala penting untuk deteksi dini kasus COVID 19

Kata Kunci    : anosmia, hiposmia, ageusia, COVID 19, gangguan olfactori.
DETEKSI DINI KEJADIAN OTOTOKSIK PADA ANAK DENGAN KEGANASAN YANG MENDAPAT KEMOTERAPI PLATINUM BASED
Authors: Asthika Ismiar , Marliyawati Dwi , Muyassaroh Muyassaroh
Published: July 2022

Latar Belakang : Kejadian ototoksik pada anak dengan keganasan yang mendapatkan kemoterapi cisplatin 60-70%. Ototoksik pada anak menyebabkan gangguan perkembangan bahasa, kemampuan verbal dan komunikasi pada anak sehingga dapat menurunkan kualitas hidup. Tujuan penelitian ini adalah mengetahui kejadian ototoksik pada anak dengan keganasan yang mendapat kemoterapi platinum based. Metode : Penelitian diskrptif analitik dengan design belah lintang pada anak dengan keganasan yang diberi kemoterapi platinum based periode Agustus – September 2020. Data diambil dari rekam medik pasien Klinik Onkologi Kasuari RSUP dr. Kariadi Semarang, ototoksik bila hasil OAE refer pada frekuensi ? 8KHz pada satu atau kedua telinga. Analisis data dengan uji-Chi-Square. Hasil : Didapatkan 38 sampel terdiri dari 22 laki - laki (57,89%) dan 16 perempuan (42,11%), dengan jenis kemoterapi cisplatin sebanyak 21 pasien (55,26%) dan jumlah pemberian kemoterapi ? 3 kali sebanyak 23 pasien (60,53%). Kejadian ototoksik lebih banyak pada jenis kelamin laki laki, banyak terjadi pada pemberian kemoterapi cisplatin dan banyak terjadi pada pemberian ? 3 siklus. Jenis kelamin (p=0,248) dan Jenis kemoterapi (p= 0,344) tidak berhubungan dengan kejadian ototoksik.Frekuensi siklus kemoterapi (p = 0,0005) berhubungan dengan kejadian ototoksik. Kesimpulan :  Kejadian ototoksik banyak pada anak laki laki, pada anak dengan keganasan yang mendapat kemoterapi cisplatin, banyak terjadi ototoksik pada pemberian ? 3 siklus, frekuensi siklus kemoterapi berhubungan dengan kejadian ototoksik
Peningkatan Kadar Bilirubin Total Serum dan Kaitannya dengan Derajat Klinis Pasien Covid-19
Authors: Rostini Tiene , Kurnia Pramono Laila , Tjandrawati Anna , Harahap Raja Iqbal Mulya
Published: July 2022

Latar belakang : Reseptor utama SARS-CoV-2, yaitu Angiotensin Converting Enzyme-2 (ACE-2) diekspresikan secara luas pada tubuh manusia. Derajat klinis infeksi Coronavirus Disease 2019 (COVID-19) bervariasi, dan diklasifikasikan menjadi asimtomatik, sakit ringan, sakit sedang, sakit berat, dan kritis. Peningkatan kadar bilirubin total serum sering dihubungkan dengan derajat klinis penyakit serta mortalitas COVID-19. Penelitian ini bertujuan untuk mengetahui peningkatan kadar bilirubin total serum dan hubungannya dengan derajat klinis infeksi COVID-19
Metode : Desain penelitian adalah cross sectional dengan pengambilan data secara simple random sampling. Data yang dikumpulkan sebanyak 73 sampel yang berasal dari RSUP Dr. Hasan Sadikin dalam periode Mei–Desember 2020. Data bilirubin total dan derajat klinis infeksi COVID-19 dianalisis menggunakan Uji Mann-Whitney dan Uji Spearman untuk mendapatkan hubungan antara kedua variabel.
Hasil : Hasil penelitian ini menunjukkan laki-laki lebih banyak dari perempuan, dengan dominasi subjek berusia 46–65 tahun, yaitu sebanyak 47,9% dari keseluruhan sampel. Median kadar bilirubin total serum pada infeksi COVID-19 derajat klinis berat-kritis lebih tinggi dibandingkan derajat klinis sedang (0,8 mg/dl vs 0,4 mg/dl), dengan koefisien r sebesar 0,463 (p<0,05).
Simpulan : Peningkatan kadar bilirubin total serum berhubungan dengan derajat klinis infeksi COVID-19 di RSUP Dr. Hasan Sadikin Bandung. Penelitian lebih lanjut dapat dilakukan secara kohort prospektif yang mengukur kadar bilirubin total serum secara serial dan menilai outcome subjek penelitian.
Pengaruh Dark Chocolate Terhadap Penurunan Tekanan Darah Sistolik Pada Penderita Hipertensi Usia 45-55 Tahun di RW.04 Desa Banjarejo Kecamatan Pakis Kabupaten Malang
Authors: Novianto Eko , Maria Lilla , Yekti Mumpuni Risna
Published: July 2022

LATAR BELAKANG : Tekanan darah tinggi atau hipertensi merupakan jenis penyakit yang harus diwaspadai. Hipertensi yang tidak dirawat dengan tepat bisa menyebabkan penderitanya mengalami komplikasi seperti serangan jantung, gagal ginjal, stroke, gangguan penglihatan, gangguan kognitif seperti penurunan kemampuan otak, sulit fokus, sulit mengingat. Penanganan non farmakologi salah satunya dengan mengkonsumsi dark chocolate, makanan ini mengandung flavanol yang dapat menurunkan tekanan darah.

TUJUAN : Penelitian in bertujuan untuk mengetahui pengaruh dark coklat terhadap penurunan tekanan darah systolic pada penderita hipertensi.

METODE : Desain peneltian yang digunakan dalam penelitian ini adalah Quasi Experiment dengan rancangan yang dipakai adalah pretest-posttest dengan kelompok kontrol (pretest–posttest with control group. Populasi seluruh penderita hipertensi usia 45-55 tahun di Desa Banjarejo pada bulan Januari 2021 sebanyak 75 responden. Sampel terdiri dari 2 kelompok, 21 responden kelompok perlakuan dan 21 responden kelompok control.

HASIL : Hasil penelitian ini menunjukkan 11 responden dari kelompok perlakuan mengalami penurunan tekanan darah sistolik setelah mengkonsumsi dark chocolatet 80% sebanyak 100gr selama 7 hari.

KESIMPILAN : Uji statistic Wilcoxon Test diketahui bahwa nilai p (0,0001) < ? (0,05) artinya Ha diterima, jadi terdapat  pengaruh pemberian dark chocolate terhadap perubahan tekanan darah systolik  pada  penderita  hipertensi.

Kata Kunci: Dark Chocolate, Hipertensi, Tekanan Darah Sistolik
Apolipoprotein E Polymorphism and Carotid Intima Medial Thickness Progression in Post Ischemic Stroke Patient
Authors: Kurnianto Aditya , Retnaningsih Retnaningsih , Tugasworo Dodik , Andhitara Yovita , Ardhini Rahmi , Budiman Jethro
Published: July 2022

Background : Apolipoprotein E (APOE) gene is believed to associate with cholesterol level, a risk factor of ischemic stroke. CIMT (carotid intima-media thickness) can be used to determine the degree of atherosclerosis. Increased CIMT may predict ischemic stroke recurrence. This study aimed to determine association between increased CIMT in post ischemic stroke patients and APOE genotype.
Methods : This was an epidemiological prospective study involving 71 post ischemic stroke patients (1 month from onset), admitted from 2012 to 2013. CIMT was examined with carotid duplex ultrasound at 1st, 6th, and 12nd month after stroke onset. APOE gene polymorphism was examined using HRM (high-resolution melting) which is a simple method, accurate, and sensitive for genotyping.
Results : We found 5 APOE gene variation categories, i.e. E2E3, E2E4, E3E3, E3E4, and E4E4. The most common allele was E3 and genotype groups E3E3 was the majority of the population. E2E4 allele had the highest CIMT level among others, in the 1st month, 6th month, and 12nd month after stroke, with no association with hypertension, diabetes, and hypercholesterolemia. E3E3 allele was most often associated with hypertension, diabetes mellitus, dyslipidemia, and hyperhomocysteinemia.
Conclusion : The results showed that APOE genotype E2E4 may independently constitute risk factor for atherosclerosis progression (CIMT) in post ischemic stroke patients. While the E3E3 genotype was often associated with hypertension, diabetes mellitus, dyslipidemia, and hyperhomocysteinemia. Our results suggest that APOE E4 was not an important risk factor for carotid atherosclerosis in post ischemic stroke patient.
Factors Influencing the Delay in Negative Conversion of PCR Swab Test Results in Patients with COVID-19
Authors: Nurkholis Fathur , Hanang Wibisono Banteng , Suryanto Agus , Handoyo Thomas , Farida Farida , Tanamas Jimmy
Published: July 2022

Background : The negative conversion duration of SARS-CoV-2 RNA was related to disease progression, and a prolonged negative conversion could provide early warning signal for poor prognosis in patients with COVID-19. The objectives of this study was to identify the factors influencing the delay in negative conversion of PCR swab test results in patients with COVID-19 as a consideration in determining the COVID-19 prevention policy in the community
Methods : A retrospective cross-sectional study involving 68 patients diagnosed with COVID-19 that was treated in Dr. Kariadi General Hospital Medical Center Semarang from June 1st to December 30th 2020. Negative conversion was evaluated based on the results of the RT-PCR swab test on day 7, 14 and 21.
Results : Mean negative conversion time for all patients was 11.63±5.08 days. Thirty-one factors were evaluated in the initial univariate Cox and Kaplan-Meier analysis. Older age (>59 years), overweight (>25 kg/m2), fever (>38°C), shortness of breath, diabetes mellitus, neutrophilia, hypoalbuminemia, CRP and antiviral treatment showed significant association with negative conversion time. These factors were then included in a multivariate regression analysis. Hypoalbuminemia or albumin level of <3.0 g/dL was found as an independent factor associated with negative conversion time of viral RNA (HR:1.986; 95%CI:1.098–3.594), and hypoalbuminemia was presumed to cause prolonged viral clearance time in patients with COVID-19.
Conclusion : The factors influencing the prolong in negative conversion of viral RNA in patients with COVID-19 were older age, overweight, fever, shortness of breath, diabetes mellitus, neutrophilia, hypoalbuminemia, CRP and antiviral treatment. Hypoalbuminemia was an independent predictor for prolonged negative conversion of viral RNA in patients with COVID-19.
Pemberian Aromaterapi Lavender sebagai Intervensi Mandiri Keperawatan dalam Meningkatkan Kualitas Tidur Pasien Congestive Heart Failure Pasca Operasi Bedah Jantung di Ruang Elang I RSUP Dr. Kariadi Semarang
Authors: Wardiyana Wayan , Sumarni Sumarni
Published: July 2022

Latar belakang : Masalah gangguan pola tidur adalah simptom yang paling sering dilaporkan pada pasien CHF dan dirasakan oleh 75% penderitanya. Sedangkan pada pasien pasca bedah jantung diketahui terdapat hubungan yang erat antara stres emosional dan kualitas tidur pasien setelah menjalani operasi bedah jantung. Perawat mempunyai peran yang penting untuk meningkatkan kualitas tidur pasien melalui intervensi nonfarmakologi salah satunyadengan pemberian aromaterapi lavender. Laporan kasus ini bertujuan untuk mengetahui efektifitas pemberian aromaterapi lavender terhadap peningkatan kualitas tidur pada pasien Ny. S dengan CHF pasca operasi bedah jantung.
Laporan kasus : Saat pengkajian pasien Ny. S pasca operasi bedah jantung hari ke–4 setelah pindah dari ruang ICCU. Pasien mengeluh sulit tidur saat malam hari dan kualitas tidurnya sangat kurang, sehingga diagnosa keperawatan prioritas pada pasien Ny. S yaitu gangguan pola tidur. Perencanaan keperawatan yang disusun bertujuan untuk meningkatkan kualitas tidur Ny. S dengan intervensi sesuai NIC Sleep Enhancement. Salah satu intervensi yaitu dengan mambantu pasien untuk rileks dengan memberikan aromaterapi lavender.
Pembahasan : Setelah pemberian aromaterapi lavender kualitas tidur Ny. S menjadi lebih baik, dari aspek lama tidur, latensi tidur, efisiensi tidur, tidak banyak gangguan yang dirasakan saat malam hari, serta pada saat siang hari Ny. S merasa lebih segar dan semangat. Secara umum Ny. S menilai kualitas tidurnya baik setelah diberikan aromaterapi lavender.
Simpulan : Pemberian aromaterapi lavender sebagai intervensi mandiri keperawatan efektif dalam meningkatkan kualitas tidur pasien CHF pasca operasi bedah jantung.
Satu Kasus Diagnostik Disfagia pada Bayi dengan Pemeriksaan FEES (Flexible Endoscopy Evaluation of Swallowing
Authors: Dewi Nila Santia , Budiarti Rery , Muyassaroh Muyassaroh
Published: July 2022

Latar belakang : Disfagia adalah gangguan proses menelan yang dapat mengganggu keselamatan dan kecukupan nutrisi. Disfagia pada bayi terjadi 85% pada anak-anak penyandang cacat dan 5% anak-anak perkembangan biasa. Tujuan penulisan laporan kasus ini untuk mengetahui sejak dini penyebab disfagia pada bayi sehingga dapat dilakukan tatalaksana segera agar tidak mengganggu pertumbuhan dan perkembangan bayi.
Laporan kasus : Dilaporkan satu kasus anak laki-laki usia 2 bulan dengan disfagia fase orofaringeal e.c curiga komplikasi iatrogenik dan perilaku. Hasil pemeriksaan Fiberoptic Endoscopic Evaluation of Swallow (FEES) didapatkan kesan kelemahan otot daerah sinus piriformis sisi kiri.
Pembahasan : Disfagia pada bayi dapat merugikan dan berpengaruh terhadap asupan nutrisi makanan sehingga mengganggu pertumbuhan dan perkembangan anak. Penyebab disfagia pada bayi yaitu prematur, kelainan neurologi, masalah maternal & perinatal, abnormalitas kongenital, gangguan pernafasan & jantung, gangguang saluran cerna, dan komplikasi iatrogenik. Diagnosis disfagia pada bayi ditegakkan dengan evaluasi klinis, instrumental alat dengan pemeriksaan Videofluoroscopic Swallowing Study (VFSS) sebagai standar emas dan Fiberoptic Endoscopic Evaluation of Swallow (FEES) sebagai alternatif.
Simpulan : Disfagia pada kasus ini termasuk disfagia fase orofaringeal dicurigai terjadi karena komplikasi iatrogenik (pemakain NGT) dengan FEES sebagai pemeriksaan penunjang.
Faktor yang Mempengaruhi Ketersediaan Pemberian Asi Eksklusif pada Pertumbuhan dan Perkembangan Bayi Usia 6 Bulan
Authors: Lau Leon , Tamba Ernawaty , Pasaribu Donna Mesina
Published: July 2022

Berdasarkan data Kementrian Kesehatan Republik Indonesia, pada tahun 2013 cakupan pemberian ASI (Air Susu Ibu) eksklusif adalah 54.3%, namun masih banyak provinsi yang belum mencapai angka cakupan pemberian ASI eksklusif. Menurut World Health Organization (WHO) angka capaian tersebut masih 50%. Dampak yang terjadi dari tidak memberikan ASI eksklusif adalah keterlambatan pertumbuhan dan perkembangan pada bayi. Tingkat pertumbuhan bayi sangat dipengaruhi oleh kualitas pemberian ASI, sehingga perlu diketahui faktor yang mempengaruhi ketersediaan ASI dari seorang ibu.  Penelitian bertujuan untuk mengetahui pengaruh pemberian ASI eksklusif dan faktor-faktor lainnya yang dapat mempengaruhi pertumbuhan dan perkembangan bayi berusia 6 bulan. Penelitan ini diadakan pada bayi berusia enam bulan, di Puskesmas Kecamatan Grogol Petamburan, pada Oktober - Desember 2020 menggunakan kuisioner. Data kemudian dikumpulkan dan diolah dengan menggunakan aplikasi SPSS. Hasil penelitian didapatkan cakupan pemberian ASI Eksklusif di Puskesmas Kecamatan Grogol Petamburan sudah mencapai cakupan yang disarankan oleh WHO. Penelitian ini menyimpulkan bahwa terdapat hubungan antara pemberian ASI Eksklusif dengan panjang badan, berat badan, dan perkembangan bayi.
Posisi dan Lama Duduk saat Bekerja dalam Menimbulkan Low Back Pain
Authors: Hartanto Hartanto , Hartono Budiman , Margaret Theodora
Published: July 2022

Low back pain (LBP) adalah sensasi nyeri pada regio L1-S1 yang dapat menjalar hingga ke arah tungkai dan kaki. Posisi dan lama duduk saat bekerja menjadi salah satu faktor yang menyebabkan timbulnya keluhan LBP. Tujuan dari studi literatur ini adalah untuk mengetahui posisi dan lama duduk saat bekerja dalam menimbukan LBP. Metode yang digunakan dalam studi literatur dilakukan dengan pencarian artikel dalam database jurnal penelitian yaitu Google Scholar dan Pubmed. Hasil penelusuran literatur, diperoleh 11 artikel yang memenuhi kriteria inklusi dan ekslusi. Posisi duduk tegak dan membungkuk meningkatkan keluhan LBP, karena mempengaruhi besarnya tekanan yang diberikan pada tulang belakang. Tekanan ini akan menimbulkan mikrotrauma disertai dengan peradangan sehingga muncul rasa nyeri pada punggung bawah. Durasi duduk >4 jam cukup menimbulkan keluhan LBP dan resiko LBP semakin meningkat bila duduk dalam waktu yang lebih lama, yakni 6–9 jam dan >9 jam. Duduk yang terlalu lama akan menyebabkan otot menjadi lelah sehingga mengurangi dukungan otot ke tulang belakang. Hal ini menyebabkan tekanan pada ligamen dan diskus intervertebralis meningkat. Pada studi literatur ini juga ditemukan faktor lain yang dapat menimbulkan LBP yaitu: usia, sandaran kursi, masa kerja dan stretching.
Efektivitas Tanaman Sambiloto (Andrographis Paniculata) dan Senyawa Andrographolide dalam Menghambat Infeksi COVID-19 : Literature Review
Authors: Christina Shintia , Meta Kali Kristin Natalia , Angeline Reni
Published: July 2022

Andrographis paniculata (AP) telah lama digunakan sebagai bahan jamu oleh masyarakat lokal Indonesia karena tanaman tersebut mudah ditemukan di pekarangan rumah. Sejak terjadinya pandemi COVID-19 berbagai upaya penanganan dilakukan, mulai dari farmakologis dan non-farmakologis. Berbagai tanaman herbal yang berpotensi menjadi pengobatan COVID-19 mulai diuji, termasuk Andrographis paniculata. Untuk mengetahui manfaat dan mekanisme Andrographis paniculata dalam pengobatan COVID-19, dilakukan studi literature review dengan penelusuran data berupa jurnal ilmiah yang dipublikasi dalam 2 tahun terakhir sejak pandemi dimulai. Pada akhir hasil studi ini, Andrographis paniculata menunjukkan fungsinya dalam menghambat COVID-19 melalui mekanisme pencegahan perlekatan virus dengan reseptor permukaan sel dan penghambatan replikasi virus.
As sociedades em risco e os múltiplos fatores que fragilizam as relações sociais em tempos de pandemia
Authors: Faria Lina , de Castro Santos Luiz Antonio , Chavez Alvarez Rocio Elizabeth
Published: July 2022

O texto é uma reflexão sobre as noções de risco, vulnerabilidades, desigualdades, violências e seus impactos nas sociedades em tempos de pandemia. Abordar as interrelações entre esses conceitos e os fatores que fragilizam as relações sociais é uma problemática que ainda carece de discussão. O objetivo foi analisar algumas proposições conceituais e epistemológicas da teoria da sociedade global de risco de Ulrich Beck, da teoria dos sistemas e o conceito de risco de Niklas Luhmann e a produção de sentidos sobre riscos de Mary Jane Spink, em consonância com a relação paradoxal entre autonomia e vulnerabilidade no “pensar e agir” humano de Paul Ricoeur. Aborda também, o cenário de aprofundamento das desigualdades e das violências entre os grupos em situação de vulnerabilidade, em tempos de pandemia, mais evidente em função do crescimento das taxas de homicídios nos últimos três anos. Essas análises ajudam a entender as inseguranças com as quais a sociedade de risco diariamente se defronta, como uma pandemia, que podem fragilizar ainda mais as condições básicas de vida das populações em situação de vulnerabilidade e ampliar as desigualdades e violências.
Voltar no passado mirando o futuro: Os limites e avanços das políticas de memória no Brasil nos governos da Nova República
Authors: Almeida Resende Pâmela
Published: July 2022

Nas últimas décadas, com o processo de redemocratização ocorrido a partir dos anos de 1980, os países da América Latina implementaram importantes medidas para enfrentar o legado autoritário nas sociedades contemporâneas. A presença dos familiares dos mortos e desaparecidos políticos é fundamental nesse processo, enquanto sujeitos centrais na luta por memória, verdade e justiça. No caso brasileiro, entre o final da ditadura civil-militar, em 1985, e a criação da Comissão Nacional da Verdade, em 2012, passaram-se 27 anos. O objetivo deste artigo é analisar como o tema das violações aos direitos humanos foi incorporado nos governos da Nova República, observando os limites, avanços e retrocessos nas políticas de enfrentamento do passado e suas reverberações no presente.
Outline of a sociology of intimate troubles: The “passages” of a single self between Evangelicalism and crime
Authors: Silva Corrêa Diogo , Grillo Barbara
Published: July 2022

This article is a study on life trajectories and changes of the self of one single person, following the transformation processes that occurred in Rio de Janeiro’s favelas during the last two decades and focusing on the relationship between Evangelicals and drug traffickers. Based on an ethnography of almost two years in Cidade de Deus favela, the trajectory of a single individual, a former drug dealer and a crack addict who switched between the church and the traffic throughout the fieldwork process, is presented in what can be called sociology of intimate troubles or sociology of self-inquiry, that is, a methodology that aims to capture the actors through their problems.
Conservadorismo religioso na política brasileira: A discreta presença da teologia política calvinista na esfera pública
Authors: Bahia Joana , Tuguio Ladeira Kitagawa Sergio
Published: July 2022

O texto aborda as conexões por afinidade eletiva entre o calvinismo e o conservadorismo moral, político e econômico em vigor no Brasil contemporâneo, que sustenta a construção de identidades e representações do bolsonarismo. O foco recai não sobre uma denominação evangélica, mas sobre a teologia política calvinista que defende a participação ativa do cristão evangélico na esfera pública professando sua fé sem necessariamente fazê-lo em linguagem religiosa. Assim, o trabalho mapeia e analisa redes de relacionamento com presença calvinista afim de compreender a difusão de ideias religiosas que apresentam afinidade eletiva com o conservadorismo bolsonarista. São destacadas quatro redes de relacionamento com presença calvinista: 1) entre religiões cristãs (IBDR); 2) entre juristas evangélicos (ANAJURE); 3) entre pensadores conservadores (Burke Instituto Conservador); e 4) entre denominações evangélicas (Coalizão pelo Evangelho).