bluuebunny/crossref_metadata_2025 huggingface dataset:
Multiparameter magnetic resonance imaging in the diagnosis of herpes encephalitis in children
Authors: Marchenko N. V. , Voitenkov V. B. , Gorelik E. Yu. , Bedova M. A. , Klimkin A. V. , Artemov D. A.
Published: January 2022

Introduction. This study is determined with the high prevalence of encephalitis in children, as well as the severe course and the possible disability. Herpes encephalitis occurs in almost half of cases of viral encephalitis in children. It is known that changes on the brain magnetic resonance imaging (MRI) in the acute stage of the disease are detected more often than on brain computed tomography (CT), but the clarification of this brain MRI changes is needed.Objectives of the study. To assess the features of brain multiparametric MRI changes in herpes encephalitis in children.Materials and methods. Two groups of children were examined, the first group included 25 children aged 6,0±4,8 years with laboratory-confirmed acute EH, the second group (control) — 23 children without signs of central nervous system damage at the comparable gender and age. Structural changes were assessed using MRI of the brain in T1-WI, T2-WI, Flair, T1-WI modes post contrast, DWI, DTI and MR spectroscopy.Results. In 40% of cases revealed panencephalitis, 36% — leukoencephalitis, 24% — polioencephalitis. Most often, the process involved the cerebral hemispheres — 72%, the brain stem — 44%, the thalamus — 40% and basal nuclei — 36%. In 52% of cases changes in DWI were found, in 20% of cases the lesions accumulated contrast agent. There was a statistically significant decrease of FA both in the focus and in the intact area in children with EH compared with the control group.Conclusion. The application of multiparametric MRI using DWI, DTI, and MR spectroscopy methods are statistically significant for the detection and assessment of focal brain lesions in children with herpes encephalitis.
Диагностические возможности пренатальной эхографии в диагностике аномалий разви- тия срединных структур головного мозга во втором триместре беременности
Authors: Kozlova O. I. , Medvedev M. V.
Published: January 2022

Introduction. Тhe application of the volume ultrasound expands opportunities of prenatal diagnosis and increases the detection of brain abnormalities.Objective: to assess diagnostic capabilities of ultrasound in prenatal diagnosis of the cerebral midline structures abnormalities in the second trimester of pregnancy.Materials and methods. 39 women, who had fetuses with cerebral midline structures abnormalities, were included into the study.Results. Abnormal image or absence of the septum pellucidum are informative signs of the cerebral midline structures abnormalities. Agenesis of the corpus callosum always has indirect ultrasound signs.Conclusion. The volume ultrasound improves the multiplane fetal brain assessment, prenatal diagnosis of brain abnormalities.
Análisis de procedimientos autorreferenciales en algunas producciones teatrales de Luis Palacio a partir del estudio del material significante escénico
Authors: Palasí Mario Alberto
Published: January 2022

Las tensiones entre ficción y realidad en la escena se producen a partir del desplazamiento de los materiales significantes de los creadores desde su propio deseo. Desde el análisis de estos materiales en movimiento, tanto en el texto dramático como en la escena, en los cuadernos de bitácora y en las entrevistas con los creadores, utilizando como herramienta metodológica los vectores deseantes (Pavis, 2000), observamos que no sólo son procesos autorreferenciales los géneros docudramas, autoperformances, autoficciones y biodramas, sino que todo espectáculo, ficcional o no, tiene una carga autorreferencial relacionada con las segmentaciones de territorialización, des-territorialización y re- territorialización.Estos procedimientos de autorreferencialidad fueron estudiados en las producciones de Palacio, dramaturgo, director y actor de la provincia de San Luis, Argentina.
MELODY TRAINING WITH SEGMENT-BASED TILT CONTOUR FOR QURANIC TARANNUM
Authors: Mohamed Hanum Haslizatul , Md Abas Luqmanul Hakim , Aziz Aiman Syamil , Abu Bakar Zainab , Mat Diah Norizan , Wan Ahmad Wan Fatimah , Mohamad Ali Nazlena , Zamin Norshuhani
Published: January 2022

Tarannum, or melodic recitation of Quranic verses, employs the softness of the voice in reading the holy verses of the Quran. Melody training technology allows users to practise repetitively while also providing feedback on their performance. This paper describes an application that captures the pattern of tarannum melodies (from Quranic recitations) and provides feedback to the user. Recordings of Quranic verses are collected from an expert reciting Bayati tarannum. The samples are pre-processed into segmented tarannum verse-contours using pitch sequences. Using the k-Nearest Neighbor (kNN) classifier, the melody patterns are trained on 20 samples. Input vectors are formed by computing the melody verse-contour representation using mean, standard deviation, and slope values and combining them with an identified Tilt-based contour label. A tarannum training prototype is built to test similarity between a user’s recitation and the trained patterns. To identify similarity between a pair of verse-contours, the application employs a shape-based contour similarity algorithm. The proposed application also provides feedback in the form of a grade and a percentage of accuracy, as determined by a melody curve similarity algorithm. As results, the current samples have an overall shape-based weighted score of 66%. Some samples are successfully classified with a similarity score as high as 80% individually. The study provides an alternative interactive session for people who want to learn Tarannum, as well as a preliminary step toward understanding the melodic patterns for tarannum. The application provides a repetitive training experience and encourages users to improve their recitations in order to achieve the highest possible score.
AUTOMATED ARABIC ESSAY SCORING BASED ON HYBRID STEMMING WITH WORDNET
Authors: Alobed Mohammad , M Altrad Abdallah M , Abu Bakar Zainab Binti , Zamin Norshuhani
Published: January 2022

Schools, universities, and other educational institutions have been forced to close their doors because of the coronavirus outbreak. E-learning has become an option and has long been discussed about the need to integrate it into the educational process-learning uses a variety of evaluation methods, one of which is the essay. This research introduces a new model for Arabic Automated Essay Grading (AAEG) that has been developed to reduce human bias mistakes and costs while saving time. However, (AAEG) is still in its infancy. The model relies on new hybrid stemming with Arabic WordNet (AWN). The primary goal of stemming is reducing inflectional forms of words to root words. The hybrid method is based on different techniques: Extended Light Stemmer, ISRI, and looking at tables (AWN). Data used in this study consists of 3050 words with their roots were retrieved from (AWN) and then stemmed using algorithms (Light10, ISRI, Hybrid...). For evaluation, the metrics used were accuracy, precision, recall, and F1-score. While comparing the performance of the different stemming algorithms, the hybrid stemming method had the greatest results, therefore the (AAEG) will improve with Hybrid Stemming.
LC method for quantitative determination of Ciprofloxacin in ophthalmic ointment
Authors: Aza-Gnandji Lionel Salem , Bueno Livia Maronesi , Oppe Tércio Paschke , Schapoval Elfrides Eva Scherman
Published: January 2022

The objective of the study was to validate an analytical method for the quantification of ciprofloxacin in ophthalmic ointment by high performance liquid chromatography. The chromatographic separation of ciprofloxacin hydrochloride was achieved on a Thermo hypersil Gold C18 column using UV detection at 278 nm. The optimized mobile phase consisted of a mixture of 0.025 M phosphoric acid with a pH previously adjusted with triethylamine to 3.0 and acetonitrile (85:15, v / v). The validation method yielded good results demonstrated statistically that the method was linear, precise, accurate, specific and robust. No interference from any components of the pharmaceutical dosage forms was observed.
O ESQUECIMENTO: UM LEITMOTIV DE ERICO VERISSIMO
Authors: Ferreira dos Santos Maria Cristina
Published: January 2022

Há uma vasta fortuna crítica acerca das obras de Erico Verissimo, sob diferentes enfoques exegéticos. No entanto, a questão do esquecimento, sua forte presença em todos os seus romances, como determina as ações das personagens e os desfechos, tornando-se um leitmotiv, carece de estudo. Dessa forma, o presente artigo, que é um recorte de minha tese doutoral, tem como escopo evidenciar as recorrências dos diversos tipos de olvido – como refúgio, de reserva, involuntário, político, autoimposto e impossível – nas narrativas do autor e como são forças motrizes para os enredos. Além disso, Erico Verissimo contribui com um novo viés para a história do esquecimento. Serão utilizados os pressupostos teóricos de Harald Weinrich, Sigmund Freud, Friedrich Nietzsche, Henri Bergson, Paul Ricoeur, Iván Izquierdo, Jacques Le Goff e Pierre Nora.
SISTEMA PRISIONAL E AUTOBIOGRAFIA: DOIS OLHARES (UM QUE PASSA E UM QUE FICA) SOBRE O CARANDIRU
Authors: Rettenmaier Miguel , Viciniescki Bruna
Published: January 2022

Este trabalho se debruça sobre duas autobiografias relacionadas à extinta Casa de Detenção de SP, popularmente conhecida como Carandiru, quais sejam: Memórias de um Sobrevivente (2001), de Luiz Alberto Mendes, e Estação Carandiru (1999), de Drauzio Varella. O título do trabalho alude à condição, em detalhe entre parênteses, às circunstâncias de ambos os enunciadores, um que passa pelo espaço voluntariamente, na posição de médico, outro que fica, sob termos que fogem à sua vontade, na condição de apenado. Nessa ordem, Varella relata, sob sua visão de médico, o que presenciou nos dez anos em que conviveu com a massa carcerária da Casa de Detenção entre 1989 e 1999; Mendes, como escritor autodidata que passa por um processo de formação leitora enquanto cumpria sua pena de mais de cem anos, testemunha sobre sua vivência de habitante do Carandiru na década de 1970. A base teórica se articula com os estudos sobre autobiografia, de Lejeune (2014;2004), associados a termos conceituais de Ricoeur (2007), sobre a memória, e de Bakhtin (2016) sobre a natureza do enunciado. Nas distinções entre ambas as vozes, um ponto comum, como espaço heterotópico (FOUCAULT, 2001) o Carandiru, é focalizado, em um mesmo cenário de violências e violações
OS DESAPARECIDOS POLÍTICOS DA DITADURA MILITAR, AS UTOPIAS E A ARTE: TRÊS MORTES EM AVANTI POPOLO, DE MICHAEL WAHRMANN, E K., DE BERNARDO KUCINSKI
Authors: Dadalto Weverson , Trefzger Fabíola Simão Padilha
Published: January 2022

O romance K., de Bernardo Kucinski (2011), e o filme Avanti popolo, dirigido por Michael Wahrmann (2012), tematizam os desaparecimentos de militantes políticos durante a ditadura militar no Brasil (1964-1985); o trauma consequente desses crimes afeta não só os familiares das vítimas, mas também toda a sociedade brasileira, que ainda não elaborou seu passado violento. Tanto o escritor quanto o cineasta associam essas histórias de violência ao declínio das utopias e aos limites da representação artística no relato de situações traumáticas. Este ensaio estabelece, nesse viés, uma aproximação entre as duas obras selecionadas para análise, observando especialmente os recursos formais empregados por ambas para a expressão do sofrimento causado pela ditadura. Também são investigados os sentidos das reflexões metalinguísticas e das relações intertextuais identificadas no filme e no livro. A partir de textos crítico-teóricos de Janaína de Almeida Teles (2010, 2012), Bernardo Kucinski (2001, 2013), Jaime Ginzburg (2017) e Jeanne Marie Gagnebin (2009), entre outros, este estudo também aponta como K. e Avanti popolo provocam a sociedade brasileira a rememorar seu passado autoritário e a discutir as consequências do esquecimento da barbárie nas relações sociopolíticas contemporâneas.
HISTÓRIA E DRAMATURGIA: PASSADO E PRESENTE EM RASGA CORAÇÃO, DE ODUVALDO VIANNA FILHO
Authors: Borges Luiz Paixão Lima
Published: January 2022

Apoiado no conceito de cronotopo, criado por Mikhail Bakhtin (1895-1975), e por uma análise dialética e materialista, o presente artigo propõe uma reflexão crítica sobre a relação passado/presente como configuração dramatúrgica na peça Rasga coração, do dramaturgo brasileiro Oduvaldo Vianna Filho (1936-1974). A dialética das formas, que tem como operador do presente o realismo psicológico, e do passado o realismo épico-dialético, nos apresenta uma hibridização em que formas aparentemente contrárias se harmonizam para recontar dramaticamente quarenta anos da História política brasileira. Rasga coração não é apenas uma das maiores obras dramatúrgicas brasileiras, mas o resgate da memória como processo de revisão do comportamento de um lutador anônimo, que dedicou sua vida à luta pela transformação social do país.
DEBATES SOBRE A ESCRITA DE HISTÓRIAS LITERÁRIAS ARGENTINAS NO PÓS-DITADURA, EM “CONTIENDAS EN TORNO AL CANON”
Authors: Albuquerque de Souza Adriele
Published: January 2022

Em Contiendas en torno al canon: las historias de la literatura argentina posdicatura, a pesquisadora Guadalupe Maradei (Universidad de Buenos Aires, UBA) analisa três novas histórias da literatura argentina, que surgiram no período pós-ditadura no país. A autora observa os viéses críticos envolvidos na organização e escrita das obras, impactadas por um novo momento político, por mudanças profundas na sociedade argentina e por um trauma coletivo ainda não elaborado. Debate, também, os conflitos, permanências e alterações com relação ao cânone, evidentes nas obras analisadas; a história da literatura enquanto gênero e a presença da ideia de tensões/processos nas mesmas; a questão da autoria feminina em cada obra; e a presença da literatura de testemunho nessas publicações.
REFLEXÕES CONTEMPORÂNEAS NOS 30 ANOS DE TERRA À VISTA: DOMESTICAÇÃO E PROTEÇÃO
Authors: Silva Ariceneide Oliveira da , Lemos Marilene Aparecida , Nero Patrícia Helena
Published: January 2022

Resenha da obra Terra à vista - Discurso do confronto: Velho e Novo Mundo, de Eni Puccinelli Orlandi, com especial atenção ao capítulo IV, da segunda parte, “Domesticação e proteção: o discurso dos padres na raiz do latifúndio”.
Relación entre paneles de vidrio y colisión de aves silvestres contra ventanas en San Gerardo de Dota, San José. Costa Rica
Authors: Hernández Barboza Yandry
Published: January 2022

La colisión de aves silvestres contra ventanas es un problema recurrente en las edificaciones de la comunidad de San Gerardo de Dota. Se Analizó la problemática de la colisión de las aves silvestres contra los ventanales de edificaciones de la comunidad de San Gerardo de Dota. Esta problemática fue descrita a partir de la observación directa de la infraestructura, identificación de especies de aves y la cuantificación del número de individuos que han sufrido colisiones contra paneles de vidrio. El estudio se realizó de febrero a mayo del 2018 en el Hotel Savegre, Hotel El Trogón, Hotel Sueños del Bosque, Centro de Investigación el Quetzal y una casa de habitación, donde funcionarios, habitantes, personal de estos sitios voluntariamente enviaron sus reportes sobre aves golpeadas contra ventanas, en el proceso se tomaron datos como fecha, hora y lugar del incidente que fueron enviados junto a una fotografía del ave para posteriormente poder ser identificada. Se registró un total de 13 familias reportadas, 24 especies y 40 individuos, entre los que se encuentran 9 especies endémicas de la región, 6 especies migratorias y 18 residentes. Se observó un aumento de colisiones conforme aumentaba el área de vidrio en los edificios. Las familias más afectadas fueron Trochilidae, Turdidae, Tyrannidae, Thraupidae y Passerellidae, se encontró especies con poblaciones decrecientes como el quetzal (Pharomachrus mocinno) y el tucancillo verde (Aulacorhynchus prasinus) y especies con poblaciones amenazadas como el loro Aliazufrado (Pyrrhura hoffmanni). El número de individuos que golpean contra cristales puede representar una amenaza para la estabilidad en las poblaciones de aves
Descripción de un periodo del ciclo de vida de Alabama argillacea (Erebidae: Lepidóptera)
Authors: Zuñiga Orozco Andres
Published: January 2022

Introducción: Alabama argillacea es una especie de polilla ampliamente distribuida por toda América Central y Suramérica. Es una plaga potencialmente dañina que afecta los cultivos de algodón. A pesar de lo anterior, no existe información concreta sobre su ciclo de vida. Objetivo: Por tanto, el objetivo de nuestro trabajo es la descripción de los estadios inmaduros (larva y pupa) de esta especie y de algunos aspectos de su historia natural. Métodos: Se observaron y realizaron mediciones a los diferentes estadios de 65 individuos, los cuales inicialmente se colectaron de larvas. Se describieron los diferentes estadios en cuanto a morfología, tiempo de duración y algunos aspectos de su historia natural. Resultados: De forma general la descripción morfométrica coincidió con otros estudios. El tiempo de duración del estadio de pupa difirió con lo registrado en la literatura. Conclusiones: Se observaron diferentes comportamientos de la larva sobre plantas del género Abutilon a los descritos en la literatura sobre el algodonero, lo cual es justificable porque se trata de plantas de diferente género.
El cuidado de niños con discapacidad, actitudes de cuidadores y madres sustitutas
Authors: Arias-Becerra Nidia Johana , Lopera-Escobar Alejandra , Ayala-Hernandez Jessica María
Published: January 2022

Introducción: La labor del cuidado de niños con discapacidad en primera infancia, esta mediada por las prácticas y los conocimientos de sus cuidadores y de sus actitudes. Entender el término actitud es complejo; para su análisis, se retoma la teoría de la autodeterminación, ya que la motivación es fundamental en la labor realizada por un cuidador y determina, en gran medida, la actitud con la que se afrontan las circunstancias. Objetivo: comprender las actitudes que tienen los cuidadores de niños con discapacidad física. Materiales y métodos: estudio cualitativo, basado en la teoría fundamentada. Participaron 12 madres sustitutas a cargo de niños menores de 6 años con discapacidad motora. Se utilizó un muestreo por conveniencia, que finalizó con la saturación teórica de las categorías. La recolección de la información se llevó a cabo por medio entrevistas semiestructuradas, las cuales fueron audio grabadas y posteriormente transcritas para su análisis. Teóricamente se estudiaron las actitudes de cuidadoras de niños con discapacidad motora. Resultados: Las actitudes de las cuidadoras pueden clasificarse en tres dimensiones: afectivas, cognitivas y comportamentales, lo que permite entender su naturaleza. Por otro lado, la motivación y la autodeterminación son elementos que determinan el por qué elegir una labor como el cuidado de otra persona. Conclusiones: El cuidado, analizado en el contexto de madres sustitutas trasciende la figura de un trabajo remunerado, hacia una construcción de un rol que aporta disfrute y le da sentido a la vida.
Efecto Ecotoxicológico de la Mezcla de Aroclor 1254 y Plomo en el Bioindicador Daphnia magna
Authors: Dellafredad-Tesén Carlos Nicolás , Innacone José Alberto
Published: January 2022

Introducción: el bioensayo con la especie bioindicadora Daphnia magna Strauss, 1820 posibilita obtener el efecto ecotoxicológico agudo individual y en mezcla de diversos tóxicos químicos mediante la concentración letal media (CL50). Objetivo: determinar el efecto ecotoxicológico de la mezcla de aroclor 1254 y del plomo (Pb2+) sobre D. magna. Materiales y Métodos: se midió la CL50 siendo aroclor 1254 > Pb2+, y ulteriormente la concentración sin efecto ecológico (PNEC) para el efecto individual y en mezcla. Se contrastaron los valores de PNEC con la categoría 4 – E1 (lagunas y lagos) y E2 (ríos) del Estándar de Calidad Ambiental Peruano (Decreto Supremo N° 004 2017-MINAM –Perú). Resultados: los valores de CL50 disminuyeron de forma gradual a 48 h de exposición para ambos compuestos en forma individual y en mezcla. Se calculó la proporción – sinergia (PS) en relaciones de 1:1, 3:2 y 4:1 (aroclor 1254: Pb2+), obteniéndose mayores valores de PS en 3:2 y 4:1 en contrastación a 1:1. Conclusiones: la concentración de aroclor 1254 estimada de PNEC es similar al valor de la conservación del ambiente acuático categoría 4 – E1 y E2, y la concentración máxima para Pb2+ no es adecuada y debe reducirse para fortalecer la conservación de la biota acuática. Finalmente, el bioindicador D. magna determinó idóneamente la mezcla de aroclor 1254 y Pb2+.
Estrategias de Acompañamiento Educativo y Familiar en la Educación Inicial
Authors: Álvarez-Gallego Mónica María , Herrera-Rivera Ovidio , Guzmán-Atehortúa Natalia
Published: January 2022

Introducción: El primer capítulo dará cuenta de las percepciones sobre educación inicial y su relación con los ámbitos familiar y escolar y cómo inciden en el desempeño escolar en la infancia. El segundo capítulo referencia los estudios relacionados con las responsabilidades y obligaciones de la familia y la escuela en el acompañamiento educativo de los niños y finalmente se desarrolla un apartado que indaga las estrategias de acompañamiento educativo en el contexto familiar y escolar. Objetivo: Realizar una revisión bibliográfica sobre las estrategias de acompañamiento educativo y familiar y su incidencia en el proceso formativo en la infancia. Materiales y Métodos: El enfoque privilegiado, es cualitativo a partir de una estrategia de revisión documental. Se presenta un estudio analítico de artículos de investigación, lo cual permite evidenciar el grado de profundización que ha tenido el tema en los últimos tiempos. Resultado: Carencia de estrategias de acompañamiento en el entorno familiar que sean exitosas y favorezcan el proceso educativo de los niños. Conclusión: Las instituciones gubernamentales continúan apostándole a la vinculación familia y escuela, pero la realidad muestra una brecha entre ellas que afecta de manera indirecta el proceso educativo en la infancia.
Interactions between hormonal contraception and single or intermittently dosed rifampicin: a pharmacokinetic modelling and simulation study
Authors: Hill Jeremy , Radtke Kendra , Schoenmakers Anne , Mulder Christiaan , Grinten Emmy van der , Overbeek Floor , Salazar-Austin Nicole , Nascimento Wilcare de Medeiros Cordeiro , Brakel Wim van , Weld Ethel
Published: January 2022

Aim Scale up of rifampicin-based prevention regimens is an essential
part of the global leprosy strategy. Daily rifampicin may reduce the
effectiveness of the oral contraceptive pill (OCP), but little is known
about rifampicin’s effects at the less frequent dosing intervals used
for leprosy prophylaxis. Since many women of reproductive age who are
eligible for rifampicin-based regimens rely on OCP for family planning,
additional information characterising the interaction would enhance
scalability and acceptability of leprosy prophylaxis. Methods We used a
semi-mechanistic pharmacokinetic model to predict the expected induction
effect of rifampicin on OCP oral clearance (CL/F) when used for leprosy
prophylaxis. Rifampicin dosing schedules were selected based on
WHO-recommended and investigational leprosy prophylaxis regimens.
Uncertainty in the model was explored using a scenario analysis. Results
Hormonal contraceptive CL/F with rifampicin given as a single 600mg
dose, a single 1200mg dose, or as 600mg once every four weeks was
predicted to increase by a maximum of 12%, 14% and 14%, respectively,
and return to baseline before the next dose. Hormonal contraceptive CL/F
was predicted to increase by >20% with once-weekly and
once-daily dosing of 600mg rifampicin. Using a threshold of 20%,
rifampicin used for leprosy prophylaxis does not have a clinically
relevant interaction with OCP. Conclusion These modelling study findings
suggest that women using OCP can expect efficacy to be maintained with
coadministration of rifampicin-based leprosy prophylaxis and should
provide reassurance to stakeholders that leprosy prophylaxis need not be
accompanied by any additional specific recommendation about use of OCP.
Effects of corrective exercises on kyphotic angle reduction: A systematic review and meta-analysis
Authors: Dimitrijevic Vanja , Protic-Gava Branka , Vinaji Tatjana , Popovic Nela
Published: January 2022

Introduction. Kyphosis is a deformity of the spine characterized by excessive
backward curvature of the thoracic spine. The normal range of thoracic
kyphosis in teenagers is 20 - 40 degrees, and the diagnosis of
hyper-kyphosis is beyond 45 degrees. The aim of this review was to assess
the magnitude of the effects of various corrective exercises on kyphotic
angle reduction. Material and Methods. The Web of Science and PubMed were
searched to retrieve relevant literature. Ten studies were included in our
systematic review and meta-analysis. Results. The magnitude of the effects
of corrective exercises on the kyphotic angle correction was estimated and
the results showed a statistical significance in standardized mean
difference (-0.504, P < 0.001). The analysis of the subgroups regarding the
age showed a heterogeneity that was not statistically significant and the
magnitude of the effects in different age groups. Conclusion. The results of
our meta-analysis may be useful to many physiotherapists and clinicians in
solving problems in patients with kyphosis and hyper-kyphosis.
Congenital duodenal atresia associated with intrauterine intestinal volvulus and meconium peritonitis: A case report
Authors: Bukarica Svetlana , Antic Jelena , Zakula Nenad , Lukic Ivana , Milenkovic Marina
Published: January 2022

Introduction. Duodenal atresia is one of the most common small bowel
anomalies usually diagnosed in utero. We present a case of a newborn with
duodenal atresia associated with intestinal volvulus and meconium
peritonitis. Case Report. A premature newborn with a birth weight of 1970 g
was admitted due to radiological signs of duodenal atresia.
Intraoperatively, in addition to duodenal atresia, we found that almost all
intestinal loops were adherent to each other and to the liver in the form of
conglomerates, as a consequence of intestinal (jejunal) volvulus and
meconium peritonitis. A minimal intestinal resection was performed with
creation of duodeno-jejunal anastomosis. The postoperative course was
prolonged due to serious complications including cardiac tamponade and
sepsis. After 77 days, with full enteral feeding, spontaneous bowel
movement, and after appropriate weight gain, the child was discharged from
the clinic. Conclusion. Treating congenital anomalies of the newborn is a
challenge, even for an experienced surgeon, especially when associated with
premature birth and low birth-weight. Despite adequate surgical techniques
and intensive treatment, complex congenital anomalies are associated with
high morbidity and mortality rates.
Up-to-date breast cancer imaging
Authors: Prvulovic-Bunovic Natasa , Vucaj-Cirilovic Viktorija , Andjelic Nikola , Boban Jasmina
Published: January 2022

Introduction. Breast cancer is a major health and economic problem in Serbia.
On the one hand, most patients see a the doctor at an advanced stage of the
disease, and on the other hand, screening response rate is low. Early
detection increases the chances of survival. Digital mammography is the gold
standard in breast cancer imaging, together with supplemental ultrasound and
tomosynthesis. Mammography combined with tomosynthesis has a greater
detection rate regardless of breast density, although the difference is more
pronounced in high-density lesions, and it has fewer falsenegative results
than mammography alone. Ultrasound, apart from being a complementary method,
is ideal for ultrasound guided breast biopsy. Magnetic resonance mammography
is an imaging method with the highest sensitivity in the detection of
invasive breast cancer and has an important role in the evaluation of the
post-therapeutic response and in preoperative preparation. Magnetic
resonance spectroscopy measures the choline levels and helps to
differentiate malignant from benign lesions. It is also a promising method
for early assessment of the post-therapeutic response. Positron emission
tomography is likely to gain more significant roles in breast cancer imaging
in the near future, especially in measuring the treatment response.
Correlation between thermo-mechanical properties and network structure in Pb-As2S3 quasibinar chalcogenides
Authors: Siljegovic Mirjana , Skuban Fedor , Strbac Goran , Raonic Rados , Lukic-Petrovic Svetlana
Published: January 2022

This paper is concerned with establishing the correlation between some
mechanical, thermal and structural properties of Pbx(As2S3)100-x glassy
samples, x = 1, 2 and 3 at.%. Measurements of mechanical parameters were
performed using a Fischerscope HM2000 S nanoindentation device. The obtained
results indicated decrease in the microhardness as a function of the doping
element content, as well as a pronounced normal indentation size effect
(ISE) phenomenon in the range of lower indentation loads. In order to
describe the microhardness data in the ISE regime and to determine the load
independent microhardness value, the MPRS model was used. The increase in
glass transition temperature with heating rate observed in DSC curves was
described according to the Lasocka equation. The activation energy of
softening process was evaluated using the Kissinger?s method. The KAS model
was applied to estimate the activation energy as a function of the
conversion rate. Raman measurements were employed to investigate structural
changes due to Pb doping.
Transport properties of SM doped CeO2 ceramics
Authors: Ramesh Somoju
Published: January 2022

Pure (CeO2) and Sm doped (Ce0.8Sm0.2O2-?) ceria were synthesized by the
maltose and pectin-modified solgel process. The dense ceramic samples, with
relative density of >96%TD, were prepared by sintering of the pressed
pellets at 1300?C for 6 h. The structure and phase of Ce0.8Sm0.2O2-?
samples were analysed by XRD method. Raman spectroscopy studies were carried
out to study the Sm-doping effect. The microstructural images were recorded
by FE-SEM. The electrical properties were measured by impedance
spectroscopy. The association and the migration energies were calculated
from the dielectric loss tangent. The Jonscher power law was applied to
study the frequency variation of electrical conductivity. The
electricmodulus studies confirm that the charge carriers follow the hopping
mechanism.
Bioactivity evaluation of nanosized ZnFe2O4 fabricated by hydrothermal method
Authors: Hangai Bruno , Acero Gonny , Ortega Pedro , Garcia Filiberto , Simões Alexandre
Published: January 2022

In this study, we investigated the structural, microstructural, magnetic and
cytotoxic properties of encapsulated ZnFe2O4 nanoparticles. The
nanoparticles were synthesized using the microwave-assisted hydrothermal
method and their surfaces were silanized and later encapsulated with
poly-2-hydroxyethyl methacrylate (PHEMA). Due to the compatibility of Zn2+
ions with a human body, ZnFe2O4 nanoparticles are preferable among all kinds
of ferrites for biomedical applications. Quantitative phase analysis
obtained by the Rietveld refinement reveals the formation of a single-phase
spinel cubic structure. Magnetic hysteresis loops measured at 2 and 300K
reveal a remanent magnetization of 4.427 emu/g and 1.002 emu/g,
respectively. Such behaviour was ascribed to change in the inversion degree
of the spinel structure. The experimental g-factor (g = 1.897) obtained
using electron paramagnetic resonance analysis can be attributed to the
microwave heating, which induces more surface-active oxygen species. In
addition, we demonstrated that the encapsulated ZnFe2O4 nanoparticles showed
an absence of cytotoxicity at concentrations of 1.0, 10 and 20 ?g/ml against
human embryonic kidney (HEK) cells since no significant changes in cell
morphology were observed. Hence, our results indicate the possibility to
explore the use of ZnFe2O4 nanoparticles encapsulated with PHEMA for
biomedical applications, such as cancer therapies.
Single-cell Transcriptomics Reveals Novel Role of Microglia in Fibrovascular Membrane of Proliferative Diabetic Retinopathy
Authors: Hu Zizhong , Mao Xiying , Chen Mingkang , Wu Xinjing , Zhu Tianye , Liu Yu , Zhang Zhengyu , Fan Wen , Xie Ping , Yuan Songtao , Liu Qinghuai
Published: January 2022

Vitreous
fibrovascular membranes (FVMs), the hallmark of proliferative diabetic
retinopathy (PDR), cause retinal hemorrhage, detachment and eventually
blindness. However, little is known about the pathophysiology of FVM. In this
study, we employed single-cell RNA sequencing on surgically harvested PDR-FVMs
and generated a
comprehensive cell atlas of FVM. A total of 8 cellular compositions were
identified, with microglia as the major cell population. We identified a GPNMB+
subpopulation of microglia, which presented both profibrotic and fibrogenic
properties. Pseudotime analysis further revealed the profibrotic microglia was uniquely
differentiated from retina-resident microglia and expanded in PDR setting.
Ligand-receptor interactions between the profibrotic microglia and cytokines
upregulated in PDR vitreous implicated the involvement of several pathways,
including CCR5, IFNGR1 and CD44 signaling, in the microglial activation within
PDR microenvironment. Collectively, our description of the novel microglia
phenotypes in PDR-FVM
may offer new insight
into the cellular and molecular mechanism underlying the pathogenesis of DR, as
well as potential signaling pathways amenable to disease-specific
intervention.
Rare Variant Analysis of Obesity-Associated Genes in Young Adults With Severe Obesity From a Consanguineous Population of Pakistan
Authors: Saeed Sadia , Janjua Qasim M , Haseeb Attiya , Khanam Roohia , Durand Emmanuelle , Vaillant Emmanuel , Ning Lijiao , Badreddine Alaa , Berberian Lionel , Boissel Mathilde , Amanzougarene Souhila , Canouil Mickaël , Derhourhi Mehdi , Bonnefond Amélie , Arslan Muhammad , Froguel Philippe
Published: January 2022

Recent advances in genetic
analysis have significantly helped in progressively attenuating the
heritability gap of obesity and have brought into focus monogenic variants that
disrupt the melanocortin signalling. In a previous study, next generation
sequencing has revealed a monogenic aetiology in ~50% of the children with
severe obesity from a consanguineous population in Pakistan. Here we assess rare
variants in obesity causing genes in young adults with severe obesity from the
same region. Genomic DNA from randomly selected 128 young adult obese subjects
(BMI=37.2 ± 0.3; age=18.4 ± 0.3 years)
was screened by conventional or augmented whole exome analysis for point
mutations and copy number variants (CNVs). Leptin, insulin and cortisol levels
were measured by ELISA. We identified thirteen subjects carrying 13 different pathogenic
or likely pathogenic variants in LEPR, PCSK1, MC4R,
NTRK2, POMC, SH2B1 and SIM1. We also identified for the
first time in the human, two homozygous stop-gain mutations in ASNSD1 and
IFI16 genes. Inactivation of these genes in mouse models has been shown
to result in obesity. Additionally, we describe 9 homozygous mutations (7 missense, 1 stop-gain and
1 stop-loss) and 4 copy-loss CNVs in genes or genomic regions previously linked
to obesity-associated traits by genome-wide association studies (GWAS). Unexpectedly,
in contrast to obese children, pathogenic mutations in LEP and LEPR were either
absent or rare, in this cohort of young adults. High morbidity and mortality
risks and social disadvantage of children with LEP or LEPR deficiency
may in part explain this difference between the two cohorts.
Recalibration and validation of the Charlson Comorbidity Index in acute kidney injury patients underwent continuous renal replacement therapy
Authors: Lee Jinwoo , Jung Jiyun , Lee Jangwook , Park Jung Tak , Jung Chan-Young , Kim Yong Chul , Kim Dong Ki , Lee Jung Pyo , Shin Sung Jun , Park Jae Yoon
Published: January 2022

Background: Comorbid conditions impact the survival of patients with severe acute kidney injury (AKI) who require continuous renal replacement therapy (CRRT). The weights assigned to comorbidities in predicting survival vary based on type of index, disease, and advances in management of comorbidities. We developed a modified Charlson Comorbidity Index (CCI) for use in patients with AKI requiring CRRT (mCCI-CRRT) and improved the accuracy of risk stratification for mortality. Methods: A total of 828 patients who received CRRT between 2008 and 2013, from three university hospital cohorts was included to develop the comorbidity score. The weights of the comorbidities were recalibrated using a Cox proportional hazards model adjusted for demographic and clinical information. The modified index was validated in a university hospital cohort (n = 919) using the data of patients treated from 2009 to 2015. Results: Weights for dementia, peptic ulcer disease, any tumor, and metastatic solid tumor were used to recalibrate the mCCI-CRRT. Use of these calibrated weights achieved a 35.4% (95% confidence interval [CI], 22.1%–48.1%) higher performance than unadjusted CCI in reclassification based on continuous net reclassification improvement in logistic regression adjusted for age and sex. After additionally adjusting for hemoglobin and albumin, consistent results were found in risk reclassification, which improved by 35.9% (95% CI, 23.3%–48.5%). Conclusion: The mCCI-CRRT stratifies risk of mortality in AKI patients who require CRRT more accurately than does the original CCI, suggesting that it could serve as a preferred index for use in clinical practice.
Experience of extended transtriceps approach in osteosynthesis of complex fractures of the distal metaepiphysis of the humerus
Authors: Sergyeev A. Yu. , Fain A. M. , Vasa A. Yu. , Gnetetsky S. F. , Bondarev V. B.
Published: January 2022

Background.The preferred treatment for intra-articular displaced fractures is open reduction and internal fixation. The need to obtain a better visualization of the fracture geometry made it necessary to develop a large number of new approaches and their modifications.

Material and methods.The study included 186 patients with an intra-articular fracture of the distal humerus, who underwent plate osteosynthesis using the standard technique. The main group included 112 patients who were operated on using ETTA. The comparison group included 74 patients with a similar type of fracture, who were operated on using chevron olecranon osteotomy. The groups were comparable in terms of age, gender, mechanism of injury, and nature of the fracture. Long-term results were evaluated in 186 patients (minimum follow-up period – 12 months).

Results.Comparative analysis revealed that the time of surgery was reduced by an average of 20 minutes (p=0.03) in the main group. The immediate and medium-term results were assessed according to the data of physical examinations, control radiography, dynamics of the increase in the amplitude of motion in the elbow joint. The results were comparable. When assessing complications, the migration of fixators was detected in 5.5% in the main group and 16% in the comparison group. In the comparison group, failure of union of the olecranon after osteotomy, migration of wires with skin perforation, and reactive bursitis were observed.

Conclusion.1. The extended transtriceps approach provides good visualization for fixing fractures of the distal humerus. 2. Evaluation of treatment results confirms that osteosynthesis using this access allows to reduce the time and trauma of the operation, to avoid complications associated with osteotomy of the olecranon, and to carry out successful postoperative rehabilitation, achieving good functional results.
Prognostic Score for Assessing the Risk of Incisional Ventral Hernias Strangulation
Authors: Sigua B. V. , Zemlyanoy V. P. , Kozobin A. A. , Semin D. S.
Published: January 2022

The problem of treatment for strangulated incisional hernia does not lose its relevance due to the large number of postoperative complications and high mortality rates, which significantly exceed these indicators in selective surgery. One of the solutions to this problem is to identify patients with a high risk of strangulation, which will allow you to perform the operation in a timely manner and avoid possible complications. The most relevant issue is the timing of surgery in patients with postoperative hernias after strangulation.
Applying User Interface Analytics to Identify Online Shop Performance Factors
Authors: Bellanov A. , Suharyanti Y. , Daryanto Y.
Published: January 2022

The massive use of information systems and digital applications drives the growth of e-commerce, including online shops in marketplaces. However, some of the online shops are not successful. To improve their performance, the success factors of the online shops should be recognized. This study develops a model of online shop success factors. Unlike the other researches that use customer preference data from surveys, this study uses user interface analytics to develop the model. A marketplace operated in Indonesia was selected as the case study. The study begins with a scraping process of the data available at online shops' user interfaces in the marketplace. After data cleaning, outliers handling, and data clustering by product category, a series of multiple regression analyses are performed to get the model estimates. Eight variables are defined to develop the model, i.e., product price, percentage of responded chat, shop joining time in the marketplace, number of product types, number of raters, shop rating, shop reputation, and number of followers. The results of the multiple regression process show that the model estimate is specific for every product category. The final model can be used as a reference by the online shop sellers to develop their strategy to improve their shop performance. Moreover, the results also prove that user interface analytics is effective in estimating the performance factors of online shops in a marketplace.
Folk Toponymy and Offshore Fishing Ground Names on the Dudley Peninsula, Kangaroo Island, South Australia
Authors: Nash Joshua
Published: January 2022

This paper analyses data on two aspects of unofficial place-naming or folk toponymy on the Dudley Peninsula, the eastern peninsula of Kangaroo Island, South Australia, namely (1) local unofficial toponyms, and (2) offshore fishing ground names. These place-name categories reflect naming patterns that embody specific local events, history and land use in the island’s colourful past, and represent an important element of the collective memory of the area. It argues that a deeper analysis of various taxa of folk toponymy, especially in remote island locations with brief histories, can help toponymists and linguists understand broad principles involved in place-naming. Furthermore, it suggests island toponymy in Australia is an under-researched field, which deserves greater prominence in Australian place-name studies.
Saltwater Chronicles: Reading Representational Spaces in Selected Book Clubs in St. John’s, Newfoundland
Authors: P. Robertson Judith , Lewkowich David , Rottmann Jennifer
Published: January 2022

Saltwater Chronicles investigates the notion of “islandness” in contemporary Newfoundland readership through two in-depth case studies of book clubs as representational spaces in the elaboration of local knowledge and identities. We demonstrate how select Newfoundland readers perform acts of regeneration in which the lived, loved, and experiential dimensions of literary space come to invoke the permeability of psychic and geographic borders, the dangers and possibilities of the landwash, and the always-already precarious designation of limits between self and other. We provide examples of how, for these island readers, “islandness” as a symbolic point of address slips and border-crosses in the in-between semiotic spaces of literary encounter.
In or On? Island Words, Island Worlds: II
Authors: Ronström Owe
Published: January 2022

The first part of the paper examines uses and meanings of the orientational metaphors ‘in’, ‘on’, ‘out’ and ‘off’. In the discussed languages in North Western Europe there are general principles of metaphoric entailment and underlying image schemas that guide the choice of positional metaphor: islands you are normally ‘on’, and mainlands ‘in’. The second part of the paper examines cases where this use is debated or contested. The author finds that these contestations seem to be fuelled by the different relations between subject and object that positional metaphors entail. Expressions with ‘in’ highlight belonging and collective identity, enlarge objects by conceptualizing them as encompassing containers, and reduce subjects to a part of the object. Expressions with ‘on’ highlight individuality and agency, reduce the object, and enlarge the subject by placing it above the object. Such differing entailments of positional metaphors may influence how islands are positioned and understood.
Development of Information System Management Customer Satisfaction Using the Simple Additive Weighting Method and Website-Based Google Maps API at ISP XYZ
Authors: Habib Ahmad , Nova Putra Aditya , Januantoro Ardy
Published: January 2022

Internet Service Provider XYZ is a service company that provides a variety of Internet  service  package  products,  cloud data, communication networks, and complete installations,  as  well  as  various  local  and international  TV  channel  service  packages interactively  using  fiber  optic  technology. However,  over  time,  problems  arose,  where many  customers  complained  about  the troubleshooter service management provided by the ISP, for example, related to reports of disturbances  from  customers,  the  length  of time  in  handling  disturbances,  the  lack  of clarity  of  officers  who  handled  disturbances and so on which led to a decrease in the level of  customer  satisfaction.  To  deal  with  these problems,  researchers  developed  a  customer satisfaction  management  information  system by  applying  the  Simple  Additive  Weighting method supported by a website-based google maps API to solve the problems being faced by  ISP  XYZ.  The  results  of  the  system development  are  expected  to  facilitate  and speed  up  the  handling  of  problems  that  are being experienced by customers and with the application  of  the  SAW  method  can  easily find  out  the  level  of  customer  satisfaction  at the XYZ ISP.
The Use Of Fixed Assets Management System In Souvenir Centre
Authors: Farida Elisa , Koeswoyo G. Freddy , Nugroho Erdhi Widyarto
Published: January 2022

Assets have a large role in shoring up a business process in a particular entity. Without fixed assets, a business will be difficult to do its business processes well. Fixed assets owned by Souvenir Centre Group 58 have not been well recorded, from the physical amount or in accounting records. Often the recording of assets manually causes problems due to the possibility of human error. Recording the depreciation of an asset is also a necessity of an entity that runs business processes. Therefore, an application is needed that can replace the manual process to be systemized. The aim of the research to be conducted is to design and develop and implement a fixed asset inventory system at a central store by QR-Code-based "Group 58" and look at the impact it has on the process of manually recording fixed asset inventory. Designing a Fixed Asset Management System at the Souvenir Centre "Group 58", through interviews, a study of company documents, designing Use Case Diagram, ER Diagram, Flowchart, and display design. Once the system is complete, a final interview is conducted with 5 employees/owners of the Souvenir Centre "Group 58" and get the result that the use of the asset management system has a positive impact on the Souvenir Centre "Group 58".