bluuebunny/crossref_metadata_2025 huggingface dataset:
Implication of dietary phenolic acids on inflammation in cardiovascular disease
Authors: Ali Shafreena Shaukat , Ahmad Wan Amir Nizam Wan , Budin Siti Balkis , Zainalabidin Satirah
Published: July 2020

In spite of medical advances, cardiovascular disease remains a significant concern, imposing a great burden upon the economy and public health of nations by causing the highest morbidity and mortality cases globally. Moreover, it is well established that inflammation is closely linked to the pathogenesis of cardiovascular diseases. Hence, targeting inflammation seems to be a promising strategy in reducing cardiovascular risks. Currently, the importance of natural products in modern medicine is well recognised and continues to be of interest to the pharmaceutical industry. Phenolic acids are a class of phytochemical compounds that are well-known for their health benefits. They consists of various phytochemical constituents and have been widely studied in various disease models. Research involving both animals and humans has proven that phenolic acids possess cardioprotective properties such as anti-hypertensive, anti-hyperlipidemia, anti-fibrotic and anti-hypertrophy activity. Furthermore, numerous studies have proven that phenolic acids in phytochemical constituents such as gallic acid, caffeic acid and chlorogenic acid are promising anti-inflammatory agents. Hence, in this review, we outline and review recent evidence on the role of phenolic acids and their anti-inflammatory significance in studies published during the last 5 years. We also discuss their possible mechanisms of action in modulating inflammation related to cardiovascular disease.
Sudden cardiac death in children and young adults without structural heart disease: a comprehensive review
Authors: Tsuda Takeshi , Fitzgerald Kristi K. , Temple Joel
Published: July 2020

Sudden cardiac death (SCD) is a rare clinical encounter in pediatrics, but its social impact is immense because of its unpredicted and catastrophic nature in previously healthy individuals. Unlike in adults where the primary cause of SCD is related to ischemic heart disease, the etiology is diverse in young SCD victims. Although certain structural heart diseases may be identified during autopsy in some SCD victims, autopsy-negative SCD is more common in pediatrics, which warrants the diagnosis of sudden arrhythmic death syndrome (SADS) based upon the assumption that the usual heart rhythm is abruptly replaced by lethal ventricular arrhythmia. Despite current advances in molecular genetics, the causes of more than half of SADS cases remain unanswered even after postmortem genetic testing. Moreover, the majority of these deaths occur at rest or during sleep even in the young. Recently, sudden unexpected death in epilepsy (SUDEP) has emerged as another etiology of SCD in children and adults, suggesting critical involvement of the central nervous system (CNS) in SCD. Primary cardiac disorders may not be solely responsible for SCD; abnormal CNS function may also contribute to the unexpected lethal event. In this review article, we provide an overview of the complex pathogenesis of SADS and its diverse clinical presentation in the young and postulate that SADS is, in part, induced by unfortunate miscommunication between the heart and CNS via the autonomic nervous system.
Current and emerging therapeutic approaches to pulmonary hypertension
Authors: Bisserier Malik , Pradhan Natasha , Hadri Lahouaria
Published: July 2020

Pulmonary arterial hypertension (PAH) is a progressive and fatal lung disease of multifactorial etiology. Most of the available drugs and FDA-approved therapies for treating pulmonary hypertension attempt to overcome the imbalance between vasoactive and vasodilator mediators, and restore the endothelial cell function. Traditional medications for treating PAH include the prostacyclin analogs and receptor agonists, phosphodiesterase 5 inhibitors, endothelin-receptor antagonists, and cGMP activators. While the current FDA-approved drugs showed improvements in quality of life and hemodynamic parameters, they have shown only very limited beneficial effects on survival and disease progression. None of them offers a cure against PAH, and the median survival rate remains less than three years from diagnosis. Extensive research efforts have led to the emergence of innovative therapeutic approaches in the area of PAH. In this review, we provide an overview of the current FDA-approved therapies in PAH and discuss the associated clinical trials and reported-side effects. As recent studies have led to the emergence of innovative therapeutic approaches in the area of PAH, we also focus on the latest promising therapies in preclinical studies such as stem cell-based therapies, gene transfer, and epigenetic therapies.
Clinical evaluation of infiltrative cardiomyopathies resulting in heart failure with preserved ejection fraction
Authors: Madan Nidhi , Kalra Dinesh
Published: July 2020

Heart failure with preserved ejection fraction is a very common clinical problem. Its prevalence is increasing with aging of the population. A diverse group of risk factors and etiologies comprise the HFpEF syndrome. No specific therapies have been shown to improve survival for the vast majority of HFpEF cases. Restrictive cardiomyopathies account for a significant portion of HFpEF patients and are characterized by diastolic dysfunction due to infiltration of the myocardium or ventricular hypertrophy. Many of these restrictive diseases occur in the context of myocardial infiltration by other substances such as amyloid, iron or glycogen or endomyocardial fibrosis. These infiltrative diseases usually have important clues in the clinical picture and on cardiac imaging that may allow differentiation from the usual HFpEF phenotype (that is commonly seen in the older, hypertensive patient). Noninvasive diagnosis has replaced endomyocardial biopsy for most instances in the workup of these conditions. Early recognition is important to institute specific therapies and to improve prognosis. In this review, we describe 4 major infiltrative cardiomyopathies (Cardiac Amyloidosis, Sarcoidosis, Hemochromatosis and Fabry disease), and their key imaging features.
Infective endocarditis after TAVI: a meta-analysis and systematic review of epidemiology, risk factors and clinical consequences
Authors: Tinica Grigore , Tarus Andrei , Enache Mihai , Artene Bogdan , Rotaru Iulian , Bacusca Alberto , Burlacu Alexandru
Published: July 2020

Infective endocarditis (IE) represents one of the most challenging clinical entities, requiring a multidisciplinary approach. The increasing number of surgical and transcatheter heart valves replacements performed annually lead to a higher incidence of prosthetic valve endocarditis. Transcatheter aortic valve implantation (TAVI) brought a new alternative for the treatment of aortic stenosis and a new subgroup of IE with its features. We aimed to compare the incidence of IE in TAVI and surgical valve replacement (SAVR) to identify risk factors for TAVI-IE, evaluate the possible impact on mortality, and clarify the best treatment strategies. A digital scan in PubMed and SCOPUS databases was performed. 68 publications were selected to perform a meta-analysis and systematic review on epidemiology, risk factors, and mortality predictors in TAVI-IE. No significant difference in IE rate was noted between patients with TAVI and those with SAVR for in-hospital, early, mid-term and late IE. Male gender, intubation, new pacemaker implantation IE and CKD were correlated with TAVI-IE. Surgical treatment was performed in 22.3% of cases. Overall mortality for the pooled cohort was 38.3%. In a multivariate logistic regression model, surgical treatment and self-expandable device were linked to lower mortality in TAVI-IE. Even if the invasive procedure can trigger bacteremia, exposing the TAVI valve to future infection, no significant difference in IE rate was noted in our analysis between patients with TAVI and those with SAVR for in-hospital, early, mid-term and late IE. Surgical treatment of TAVI-IE can be a viable option in patients with a prohibitive risk score.
Safe performance of echocardiography during the COVID-19 pandemic: a practical guide
Authors: Cameli Matteo , Pastore Maria Concetta , Henein Michael , Aboumarie Hatem Soliman , Mandoli Giulia Elena , D’Ascenzi Flavio , Cameli Paolo , Franchi Federico , Mondillo Sergio , Valente Serafina
Published: July 2020

Coronavirus disease-2019 (COVID-19) outbreak has become a worldwide healthcare emergency, with continuously growing number of infected subjects. Considering the easy virus spread through respiratory droplets produced with cough, sneezes or spit or through close contact with infected people or surfaces, healthcare workers are further exposed to COVID-19. Particularly, echocardiography remains an essential diagnostic service which, due to the close contact with patients during the exam, provides echocardiographers high-risk of contagion. Therefore, the common modalities of performing echocardiography should be improved in this scenario, avoiding performing unnecessary exams, using the appropriate personal protective equipment depending on patients’ status and location, optimizing time-effectiveness of the echocardiographic study and accurately sanitizing the environment and devices after each exam. This paper aims to provide a simple guide for the clinicians to balance between providing the best care to each patient and protecting themselves and other patients from the spread of the virus. It also proposes the use of the mnemonic PREVENT to resume the crucial indications to be followed for the execution of appropriate echocardiographic examination during the COVID-19 pandemic.
ANALISIS RETORIKA TEKSTUAL PADA TEKS PROSEDUR, TEKS CERPEN, TEKS LINGKUNGAN, DAN KEMUNGKINAN PEMBELAJARAN DI SEKOLAH
Authors: Indahnesia Annisa
Published: July 2020

Secara etimologis istilah “wacana” berasal dari bahasa Sanskerta wac/wak/vak yang artinya berkata, berucap. Kata wacana dalam bahasa indonesia dipakai sebagai padanan (atau terjemahan) kata discourse dalam bahasa Inggris. Secara etimologis kata discourse itu berasal dari bahasa latin diskursus ‘lari kian kemari’. Kata diskursus itu diturunkan dari bentuk discurrere. Bentuk discurrere itu merupakan gabungan dari dis dan currere ‘lari, berjalan kencang’ (Wasber dalam Baryadi 2002:1).Dalam konteks tata bahasa, wacana merupakan satuan gramatikal tertinggi atau terbesar (Kridalaksana dalam Baryadi 2002:2). Hal ini berarti bahwa apa yang disebut wacana mencakup kalimat, gugus kalimat, alinea atau paragraf, penggalan wacana, dan wacana utuh.Wacana sangat berhubungan dengan retorika tekstual. Dalam kaitannya dengan bahasa, retorika tekstual berhubungan dengan bagaimana mengonstruksi teks atau wacana dengan menggunakan bahasa. (Baryadi, dalam Sumadi 2016).
Suplemen Materi Statistik Terapan dalam Ilmu Kesehatan
Authors: Jusmiana Andi , HERIANTO H.
Published: July 2020

Kata statistik berasal dari bahasa Latin "Ratio Status" yang dalam bahasa Itali ekivalendengan kata "Region di stato". Statistik dalam arti sempit hanya didefinisikan sebagai fakta-fakta berbentuk angka yang terangkum dalam tabel-tabel atau kumpulan angka pada tabel yang menerangkan suatu fenomena. Pengertian secara luas statistik diartikan sebagai metoda, cara atau teknik mengumpulkan data, mengolah data, menyajikan data, mengalisis data dan menarik kesimpulan berdasarkan data. Banyak buku yang mendefiniskan statistik secara berbeda, dalam arti sempit biasanya hanya disebut statistik, sedangkan statistik dalam arti luas biasa disebut statistika. Kegunaan Statistik Dalam Bidang Kesehatan, diantaranya: 1) memberi keterangan tentang masalah-masalah kesehatan masyarakat yang dihadapi serta hal-hal perlu mendapat prioritas; 2) Memberikan keterangan penyebaran penyakit berdasarkan orang yang diserang, waktu penyerangan, luasnya wilayah serang dan kecenderungannya; 3) memperkirakan perkembangan suatu penyakit dengan berdasarkan periodisasinya/trend; 4) memperkirakan faktor-faktor penyebab masalah, fakta yang akan dan telah terjadi; 5) memperkirakan sumber daya dan potensi pemanfaatan serta pengembangannya dalam upaya mengantisipasi permasalahan yang terjadi; 6) merencanakan upaya yang efektif, efisien berdasarkan kenyataan, prioritas dan sumber daya yang tersedia; 7) memahami, menganalisis data dan informasi guna membantu mengambil keputusan; 8) menganalisis hambatan pelaksanaan program kesehatan masyarakat serta alternatif pemecahannya; 9) menilai hasil-hasil kegiatan yang telah dicapai; 10) mendokumentasikan semua data kesehatan masyarakat, untuk dapat dibandingkan dengan daerah lain atau keadaan yang akan datang.
Analisis Penonjolan dan Kesinambungan Topik pada Teks Cerpen, Teks Prosedur, dan Teks Lingkungan
Authors: Syahfitri Wilda
Published: July 2020

Berdasarkan hasil analisis di atas dapat disimpulkan bahwa topik itu merupakan sentral kedudukannya dalam wacana, topik ditonjolkan dan dipertahankan dan diacu oleh seluruh bagian wacana dan secara garis besar, wacana berperan penting dalam pembelajaran khususnya dalam hal meningkatkan literasi siswa, baik itu kemampuan membaca atau menulisnya. Dalam pembelajaran pemanfaatan teknologi untuk mengakses teks secara cepat dan efisien juga dapat dilakukan.
Psychotherapy and Dissent
Authors: Deshpande Aayushi
Published: July 2020

The presentation was made for a class assignment (February 23, 2020, University of Pennsylvania, Course: Practicum). It outlines a practical, research-based intervention that one could design and plausibly implement in their future career.
Revisiting potential associations between brain morphology, fear acquisition and extinction through new data and a literature review
Authors: Ehlers Mana R , Nold Janne , Kuhn Manuel , Klingelhöfer-Jens Maren , Lonsdorf Tina B
Published: July 2020

Inter-individual differences in defensive responding are widely established but their morphological correlates in humans have not been investigated exhaustively. Previous studies reported associations with cortical thickness of the dorsal anterior cingulate cortex, insula and medial orbitofrontal cortex as well as amygdala volume in fear conditioning studies. However, these associations are partly inconsistent and often derived from small samples. The current study aimed to replicate previously reported associations between physiological and subjective measures of fear acquisition and extinction and brain morphology. Structural magnetic resonance imaging was performed on 107 healthy adults who completed a differential cued fear conditioning paradigm with 24h delayed extinction while skin conductance response (SCR) and fear ratings were recorded. Cortical thickness and subcortical volume were obtained using the software Freesurfer. Results obtained by traditional null hypothesis significance testing and Bayesians statistics do not support structural brain-behavior relationships: Neither differential SCR nor fear ratings during fear acquisition or extinction training could be predicted by cortical thickness or subcortical volume in regions previously reported. In summary, the current pre-registered study does not corroborate associations between brain morphology and inter-individual differences in defensive responding but differences in experimental design and analyses approaches compared to previous work should be acknowledged.
Structural Validity and Reliability of The Urdu Translated Version of IPIP - NEO - 300 Web - Based Inventory
Authors: Rehman Minhaaj , Johnson John Anthony
Published: July 2020

The NEO-IPIP-300 is a 300-item version scale of freely available personality tests based on the OCEAN Model of 30 distinctive personality traits. The scale measures human personality preferences and groups them into five distinct factors, namely Openness to Experience, Conscientiousness, Extraversion, Agreeableness, and Neuroticism. The scale has been translated into many languages before, but there was no translation and norms available for the Urdu language.Paper reports the translation, creation of web version, data collection (N=869), and reliability of Urdu version of NEO-IPIP-300. We also did a CFA Analysis and Measurement Invariance test as part of the paper. Full measurement invariance was met for the full model, and partial measurement invariance was met for neuroticism (metric and scalar) and extraversion (metric). In general, all models fit well and suggest that the Urdu IPIP-300-NEO aligns well with the English IPIP-300-NEO. In some cases, the Urdu inventory performed better (e.g., higher internal consistency) than the English inventory.
A Person-Centered Approach to Profiling COVID-Related Experiences in the United States: Preliminary Findings from the Epidemic-Pandemic Impacts Inventory (EPII)
Authors: Grasso Damion , Briggs-Gowan Margaret J. , Carter Alice , Goldstein Brandon , Ford Julian D.
Published: July 2020

The COVID-19 pandemic has had a profound impact on individuals, families, and communities around the world. Intensive health precautions have created constraints on mobility, work, education, family life, and interpersonal relationships. Preliminary survey studies have reported an increase in the prevalence and severity of psychosocial impairments in the pandemic’s immediate wake. However, the impact of specific pandemic-related experiences and patterns of experiences has not been systematically assessed and studied. The goal of the present study was to develop and conduct a preliminary empirical test of a novel, comprehensive assessment of pandemic-related experiences, the Epidemic-Pandemic Impacts Inventory (EPII), using person-centered latent class analysis (LCA). Aims were to (1) test the hypothesis that LCA would identify unique subgroups based on patterns of negative and positive pandemic-related experiences across personal and social domains, and (2) examine whether identified subgroups would significantly differ on sociodemographic characteristics and indicators of mental health and functioning. Results supported hypotheses, with several unique subgroups identified across domains that were differentiated on sociodemographic characteristics and measures of perceived stress, depression, anxiety, PTSD, and perceived social support. Findings support the EPII as an instrument for measuring tangible and meaningful experiences in the context of an unprecedented pandemic disaster. This study, combined with future research with the EPII, may serve to inform public health strategies for supporting families and communities in the current pandemic and under similar mass public health crisis circumstances in the future.
Genetic Risks, Adolescent Health, and Schooling Attainment
Authors: Amin Vikesh , Behrman Jere , Fletcher Jason , Flores Carlos A , Flores-Lagunes Alfonso , Kohler Hans Peter
Published: July 2020

We provide new evidence on the effect of adolescent health on schooling attainment using the National Longitudinal Study of Adolescent to Adult Health. We take two different approaches to deal with omitted variable bias and reverse causality. Our first approach attends to the issue of reverse causality by using health polygenic scores (PGSs) as proxies for actual adolescent health. Second, we estimate the effect of adolescent health using sibling fixed-effects models that control for unmeasured genetic and family factors shared by siblings. We find that being genetically predisposed to smoking and smoking regularly in adolescence reduces schooling attainment.
CYBERCRIME Penghinaan dan Pencemaran Nama Baik Melalui Dunia Maya
Authors: Guntara Bima
Published: July 2020

Buku ini merupakan hasil penelitian penulis terkait persoalan kejahatan di dunia maya (cybercrime) khususnya penghinaan dan pencemaran nama baik di dunia maya yang akhir-akhir marak terjadi didalam kehidupan masyarakat. Buku ini disajikan untuk melengkapi literatur dan kebutuhan akademik dalam bidang ilmu hukum pidana. Penyajian ini menjadi penting, karena pada dasarnya penghinaan dan pencemaran nama baik sangat lekat dalam kehidupan sehari-hari di masyarakat dan berkaitan erat dengan hukum pidana. Dengan hadirnya buku ini diharapkan masyarakat dapat memahami tindak pidana dalam bentuk penghinaan dan pencemaran nama baik di dunia maya. Oleh karena itu, buku ini perlu dimiliki dan dibaca, terutama bagi mahasiswa yang sedang belajar ilmu hukum khususnya kejahatan di dunia maya, termasuk juga masyarakat secara keseluruhan.
A ‘horrid way of feeding’
Authors: Bellamy Desmond Fraser
Published: July 2020

Cannibalism both fascinates and repels. The concept of the cannibal has changed and evolved, from the semi- or in-human anthropophagi of Classical texts to the ‘savage’ cannibals of colonial times, whose alleged aberrations served as a justification for invasion, conversion and extermination, to the contemporary cannibal driven often by psychosexual drives. Cannibal texts typically present the act as pervasive, aggressive and repulsive. If these parameters are admitted, alleged cannibals immediately fall outside normative European humanist morality. This paper examines cannibalism as a major delineator of the civilised human. Cannibals offer social scientists a handy milestone to confirm the constant improvement and progress of humanity. The idea that colonised peoples were not savage, degenerate cannibals threatens the concept of the ‘Great Chain of Being’, which was assumed to show an inexorable progress from plants to animals to humans, and upward toward the divine, led by enlightened Western civilisation. But cannibal mythology, factual or imaginary, offers an opportunity to re-evaluate the assumptions of human supremacism and see ourselves as edible, natural beings.
Academic Fraud
Authors: Wilson Paul
Published: July 2020

Academic fraud is a rising threat. Schemes to defraud funding bodies, institutions and researchers for personal gain are not a modern invention within academia but one that threatens to topple the integrity of research practice. These manifest in the form of internal research misconduct and external predatory practice, the former perpetrated by the over-ambitious and the latter by organizations predating on unsuspecting researchers. Such academic fraud can undermine academic integrity, profoundly influence key legislation, and cause societal damage. Major reform of the academic system is required to overcome these difficulties. These measures are discussed and can be divided into detection and prevention methods. Detection methods include peer-review, replication, whistle-blowing, external review bodies, digital solutions, and incentivization. Prevention methods include awareness, data repositories, institutional and editorial policies, punishment and deterrence, transparency indices, and changes to the ‘publish or perish’ mentality. These solutions are as of yet immature, flawed or in need of major revision but do have some potential in overcoming the rising threat of academic fraud.
O zachodnioeuropejskim i euroazjatyckim modelu integracji politycznej – próba analizy porównawczej
Authors: Węsierski Michał R.
Published: July 2020

The paper is an attempt to compare Western European and Eurasiatic models of political integration. The analysis includes an overview of the similarities and essential differences between the models. The author presents, in a concise way, the two different processes of political integration in their historical and institutional perspective, including geocultural and geopolitical background related to the forming the models under consideration.
O potrzebie jakościowej zmiany w konsultacjach społecznych w mieście
Authors: Przybylska Anna
Published: July 2020

Public consultations may contribute to the knowledge growth; among politicians it would involve needs and preferences of citizens, and among citizens it would concern budgetary constraints and other limitations to decisions in the given public policy area. Further, public consultations may also have positive effects on building mutual understanding and trust between political representatives and common members of political community. However, it is dependent on the quality of communication about consultative procedures, the transparency and justification of choices made in reference to whom to consult, how and with what aim. The article demonstrates both the empirical findings in the area of practice of public consultations in Poland as well as their critical assessment from the point of view of deliberative ideal discussed across Europe and worldwide.
Socialisation and decision-making in the Council of the European Union
Authors: Ławniczak Kamil
Published: July 2020

The complex system of decision-making in the Council of the European Union has many specific features which require explanation. This article presents a constructivist approach to this problem and focuses on the influence of socialisation. First, it explains why inquiry into the decision-making in the Council from the constructivist perspective is justified and then proposes the use of process-tracing, a method that allows to trace causal mechanisms linking the effects of socialisation and the characteristics of decision-making in the Council. Second, a typology of socialisation mechanisms and effects is presented. The third section is an attempt to use the inductive variety of process-tracing in order to explain certain qualities of decision-making in the Council. The final section outlines the theory-oriented approach to process-tracing, which could follow from the presented conceptualisation and explains the need to include the constitutive aspects of socialisation within the causal framework of process-tracing research.
Security threats and risk management: European and Chinese responses to the climate disruption
Authors: Śliwiński Krzysztof , Rakowska Agata
Published: July 2020

Most academics and policy makers agree upon irreversible phenomena affecting planet Earth’s climate – we have finally faced a climate disruption. As triggered by humans, environmental degradation ultimately threatens not only the security but even the survival of individuals, communities, states and perhaps even the international system as a whole. This paper addresses differences with regards to risk assessment of climate disruption in Europe and in China. Its departure point is that the divergence between European and Chinese approaches is based on structural and institutional distinctions. Specifically, it tries to assess those distinctions (importance of sovereignty and non-interference) with regards to methods (assessment of vulnerability) and principles (transparency and inclusiveness) of risk assessment. Initial analysis leads to a tentative conclusion, which confirms the importance of political culture in national responses to security threats (be it traditional or non-traditional). In this respect EU-China strategic partnership is suggested as one of the possibly effective platforms for future cooperation.
Does Cloud-Based Accounting Information System Harmonize the Small Business Needs?
Authors: Pramuka Bambang Agus , Pinasti Margani
Published: July 2020

Cloud technology is now becoming a valuable resource, as it provides cost-saving business technology. Businesses exist to earn a profit by keeping their capital and expenses low. In an attempt to address the issue, this study employs structural equation model to complement literature on users' technology acceptance behavior. The framework of the study was based on the technology acceptance model (TAM) to better understand the adoption of cloud computing by small businesses owners. This study looks at the perception and attitudes of small businesses (SMEs) towards cloud technology based accounting information systems, therefore, their intention to adopt the technology. Result support the view that perceived usefulness, ease of use and credibility positively influenced SMEs' attitudes towards cloud-based accounting information systems and therefore their intention to adopt the technology. The result enhances literature in the field of cloud-based accounting systems for small businesses.
A Novel Rule based Data Mining Approach towards Movie Recommender System
Authors: Sharma Mugdha , Ahuja Laxmi , Kumar Vinay
Published: July 2020

The proposed research work is an effort to provide accurate movie recommendations to a group of users with the help of a rule-based content-based group recommender system. The whole approach is categorized into 2 phases. In phase 1, a rule- based approach has been proposed which considers the users’ viewing history to provide the Rule Base for every individual user. In phase 2, a novel group recommendation system has been proposed which considers the ratings of the movies as per the rule base generated in phase 1. Phase 2 also considers the weightage of every individual member of the group to provide the accurate movie recommendation to that particular group of users. The results of experimental setup also establish the fact that the proposed system provides more accurate outcomes in terms of precision and recall over other rule learning algorithms such as C4.5.
Security Challenges Behind the Development and Increased Use of Open Source Web Content Management Systems
Authors: Viduka Dejan , Kraguljac Vladimir , Lavrnić Igor
Published: July 2020

Nowadays the IT market is enriched with free Open Source Web Content Systems offers that are available to all users. No system is perfect, and some of them have better solutions in one segment but are more vulnerable in others and vice versa, all in order to be more user-friendly. The most common form of Content Management System (CMS) implemented on the Internet today is the Web Content Management System(WCMS). This solution includes numerous advantages for site administrators as well as communication with the site designer for all users in order to improve the content, through written remarks, opinions and evaluations of the site content, resulting in a more dynamic and interactive site. This modern approach offers users with a poor IT background the opportunity to be independent and creative in creating their own website. In this paper we present data collected from several websites monitored for various cyber-attacks. Moreover, we will describe and analyze security challenges that follow cyber-attacks. During the monitoring process we followed 15 web addresses over a period of nine months and collected 520 reports of various cyber-attacks. The following analysis presents the different kinds of attacks, their frequency and some of the ways to reduce cyber-attacks to the lowest possible level.
Double and dual numbers. SU(2) groups, two-component spinors and generating functions
Authors: Torres del Castillo G. F. , Gutiérrez-Herrera K. C.
Published: July 2020

We explicitly show that the groups of $2 \times 2$ unitary matrices with determinant equal to 1 whose entries are double or dual numbers are homomorphic to ${\rm SO}(2,1)$ or to the group of rigid motions of the Euclidean plane, respectively, and we introduce the corresponding two-component spinors. We show that with the aid of the double numbers we can find generating functions for separable solutions of the Laplace equation in the $(2 + 1)$ Minkowski space, which contain special functions that also appear in the solution of the Laplace equation in the three-dimensional Euclidean space, in spheroidal and toroidal coordinates.
On the Lagrangians and potentials of a two coupled damped Duffing oscillators system and their application on three-node motif networks
Authors: Barba-Franco, J. J. , Espinoza, P. B. , Gallegos, A. , Jaimes-Reategui R. , Macias-Diaz J.E.
Published: July 2020

In this work, we investigate the Lagrangians and potentials for two coupled damped Duffing oscillators both directionally and bi-directionally. We show that, although it is not always possible to define a potential in dissipative systems, the potential of our model can be defined if the damping coefficient has a logarithmic derivative form. It is possible to apply these results to the analysis of the dynamics of complex networks based on three-node motif configurations. As an example, we study numerically the dynamics for one of the thirteen different possible configurations. Here, the phenomenon of synchronization is observed in terms of the coupling parameter.
Configuración y montaje de instrumento para la caracterización magnetoeléctrica de compuestos cerámicos multiferroicos
Authors: Camargo J. , Lere M. , Castro M. , Ramajo L.
Published: July 2020

Este trabajo presenta la configuración y montaje de un equipo empleado para la cuantificar el coeficiente magnetoeléctrico dinámico (α) de compuestos cerámicos multiferroicos. En particular, se analizan las propiedades magnetoeléctricas de los compuestos de composición Bi0.5(Na0.8K0.2)0.5TiO3-Ni0.5Co0.5Fe2O4 (BNKT-NCF). En el método dinámico, la señal magnetoeléctrica (ME) es registrada midiendo el potencial eléctrico a través de la muestra bajo un campo magnético continuo y variable en presencia de un campo magnético de CA. Los elementos de medición constan de un sistema de polarización (eléctrico y magnético), para polarizar la cerámica magnetoeléctrica, y un lock-in para generar la señal alterna y filtrar el ruido. Además, dada la baja señal ME es necesario un blindaje adecuado y una sección fina de electrodos junto al amplificador tipo lock-in. El rendimiento de los dispositivos fabricados resulta satisfactorio para realizar la medición dinámica del efecto ME para materiales magnetoeléctricos basados en cerámicos multiferroicos.
Triggerless charge measurement system for fast characterization with APDs and PMTs
Authors: Muñoz G. Tejeda , Grados Luyando M. del C. , Fernández Téllez A. , Cahuantzi M. Rodríguez , Hernández M. I. Martínez , Alonso B. de Celis
Published: July 2020

Particle detectors based on the response of sensitive material (plastic scintillator, saturated gas, etc.) usually need characterization and test procedures before final installation. Cosmic ray particles are normally used to perform those preliminary tests which includes a detailed inspection of the readout electronics and a data acquisition to obtain a charge distribution of cosmic ray detection.The Data Processing Interface is implemented in an FPGA (ALTERA family), designed to test the acquisition of digitized signals from light sensors, fotomultipliers (PMTs)  and Avalanche photodiodes (APDs) are the most common ones. The architecture is based on a medium density FPGA that continuously reads the data coming from a 10-bit, 40MHz ADC. Input data is stored in a dual port memory designed to search for valid pulses and compress them by removing data below a programmable voltage threshold. The Interface can produce two types of data packets, non-Zero packets and empty packets. Data in non-zero packets are compressed with a lossless technique and they are marked with a start of data, time stamp, valid data and data size information for reconstruction purposes. Empty events are generated when the maximum waiting time for a valid pulse is exceeded and information is added to preserve the time continuity.
Local quantum uncertainty as a robust metric to characterize discord-like quantum correlations in subsets of the chromophores in photosynthetic light-harvesting complexes
Authors: Chávez-Huerta M. , Rojas F.
Published: July 2020

Green sulfur bacteria is a photosynthetic organism whose light-harvesting complex accommodates a pigment-protein complex called Fenna-Matthews-Olson (FMO). The FMO complex sustains quantum coherence and quantum correlations between the electronic states of spatially separated pigment molecules as energy moves with nearly a 100% quantum efficiency to the reaction center. We present a method based on the quantum uncertainty associated to local measurements to quantify discord-like quantum correlations between two subsystems where one is a qubit and the other is a qudit. We implement the method by calculating local quantum uncertainty (LQU), concurrence, and coherence between subsystems of pure and mixed states represented by the eigenstates and by the thermal equilibrium state determined by the FMO Hamiltonian. Three partitions of the seven chromophores network define the subsystems: one chromophore with six chromophores, pairs of chromophores, and one chromophore with two chromophores. Implementation of the LQU approach allows us to characterize quantum correlations that had not been studied before, identify the most quantum correlated subsets of chromophores, and determine that, in the strongest associations of chromophores, the LQU is a monotonically increasing function of the coherence.
Virus Zika en el embarazo
Authors: Chaves Loaiza Estefanía , Silva Díaz Romario Francisco , Johynny Bernarda
Published: July 2020

El virus del Zika es un flavivirus de la familia Flaviviridae. Fue aislado por primera vez en 1947, en el bosque de Zika en Uganda. Se identificó en América en 2014 en la Isla de Pascua, Chile. Múltiples estudios demuestran una fuerte asociación de la infección durante el embarazo y una predilección para el tejido neuronal, aumentando el riesgo de presentar malformaciones fetales, de las cuales la microcefalia ha sido el hallazgo predominante. Sin embargo, muchas otras manifestaciones clínicas e imagenológicas se pueden encontrar e incluir en el llamado síndrome de Zika congénito. La infección del feto debería ocurrir durante el primer trimestre, donde el trofoblasto es más permisivo para el virus Zika que en el tercer trimestre, período en el cual hay mayor producción de INF λ l, factor protector contra la infección por virus Zika.  Por esta razón, la OMS lo declaró en 2016 como una emergencia de salud pública y de interés nacional.
Protocolo de análise rápida: alternativa para avaliar qualidade ambiental em riachos de cabeceira em Mata Atlântica, Sul do Brasil
Authors: Marques da Silva Jair , Larissa Rauch Caciane , Biasi Cristiane , Ubiratan Hepp Luiz , Secretti Decian Vanderlei , Maria Restello Rozane
Published: July 2020

Este trabalho teve por objetivo elaborar um Protocolo de Análise Rápida (PAR) destinado à avaliação da diversidade de habitats e do nível de conservação de riachos, como ferramenta para o monitoramento e a gestão de bacias hidrográficas. Para a elaboração do PAR foram selecionadas duas Bacias Hidrográficas, uma no Rio Grande do Sul e uma em Santa Catarina. A partir dos dados de uso e ocupação da terra, foram selecionados quatro trechos de riachos onde foram elencados 19 parâmetros. Para cada característica do parâmetro atribui-se uma pontuação de 0 a 4 pontos, de acordo com uma condição de estresse ambiental. Ao final, a somatória da pontuação dos parâmetros classifica os trechos em natural, alterado e impactado. Dos trechos selecionados, apenas um em cada bacia apresentou-se natural; os demais, alterados ou impactados. O protocolo elaborado foi validado pela aplicação do índice Biological Monitoring Working Party (BMWP) que usa macroinvertebrados bentônicos como bioindicadores. Esta validação demonstrou resultados semelhantes em 50% dos trechos avaliados, com uma correlação positiva entre os resultados do PAR e do BMWP (r=0,85). Assim, o uso de PAR pode ser considerado uma ferramenta de avaliação eficiente, além de proporcionar a gestão participativa e integrada que é preconizada pela Política Nacional de Recursos Hídricos.
Invertebrados associados a detritos de macrófitas aquáticas em área úmida subtropical do Sul do Brasil
Authors: Faria Albertoni Edélti , De Azevedo Carneiro Thais , Palma-Silva Cleber
Published: July 2020

Macrófitas aquáticas são abundantes em ecossistemas rasos da Planície Costeira do Rio Grande do Sul. A velocidade de decomposição dessas plantas é regulada pela qualidade nutricional do detrito, pela presença de compostos inibidores de fitófagos e presença de invertebrados fragmentadores. Em sistemas subtropicais e tropicais, é relatada a virtual ausência de fragmentadores participando desse processo. Este estudo teve como objetivo principal avaliar a decomposição de três espécies de macrófitas aquáticas em uma área de banhado no Sul do Brasil. Foram medidos concentração de carbono e nitrogênio, teores de polifenóis e a comunidade de invertebrados, classificando-os em grupos tróficos funcionais. Os resultados demonstraram que a planta com maior concentração de nitrogênio e menor teor de polifenóis teve a maior velocidade de decomposição. A comunidade de invertebrados associados teve baixa presença de fragmentadores e maior abundância de raspadores. Sugerimos que o papel de fragmentação de detritos por invertebrados em áreas úmidas subtropicais pode estar sendo subestimado. Provavelmente, o detrito não está sendo utilizado como recurso alimentar, mas os mecanismos de comportamento alimentar de organismos raspadores auxiliam na quebra da matéria orgânica nesses sistemas, incrementando a velocidade de degradação.
Kapabilitas Dynamic Governance Dalam Pencapaian Pertumbuhan Ekonomi Provinsi Kepulauan Riau Tahun 2012 – 2017
Authors: Tuah Fitriano Putra Donie
Published: July 2020

Pertumbuhan ekonomi Provinsi Kepulauan Riau mengalami penurunan sejak tahun 2012 hingga 2017. Pemerintah sebagai aktor utama governance menjadi insititusi yang harus lebih responsif, memunculkan kebijakan yang adaptif sebagai solusi. Kapabilitas pemerintah menjadi ukuran keberhasilan kinerja perekonomian dalam pencapaian pertumbuhan ekonomi. Penelitian ini bertujuan untuk menganalisis kapabilitas pemerintah dalam pencapaian pertumbuhan ekonomi Provinsi Kepulauan Riau tahun 2012-2017. Kapabilitas pemerintah dianalisis dan dideskripsikan menggunakan enam indikator dalam teori Dynamic Governance, yakni: (1) Thinking ahead; (2) Thinking again; (3) Thinking across; (4) Able people; (5) Agile Process; (6) Culture. Metode penelitian yang digunakan adalah metode penelitian kualitatif. Hasil penelitian menunjukkan bahwa kapabilitas pemerintah Provinsi Kepulauan Riau belum mencerminkan kapabilitas dynamic governance. Di mana empat dari enam indikator belum terwujud pada penyelenggaraan pemerintahan. Kebijakan adapatif yang dihasilkan dalam implementasinya tidak konsisten dilakukan, bahkan ada yang tidak berjalan yang akhirnya tidak mampu meningkatkan pertumbuhan ekonomi daerah.
Karakter Birokrasi Pemerintahan Dalam Pelayanan Perizinan Mendirikan Bangunan Di Dinas Penanaman Modal Pelayanan Terpadu Satu Pintu Kabupaten Karawang
Authors: Ramdani Rachmat
Published: July 2020

Penelitian ini bertujuan untuk menganalisis karakter birokrasi pemerintahan dalam pelayanan perizinan IMB di DPMPTSP Kabupaten Karawang. Penulisan ini di latarbelakangi birokrasi pemerintahan di Kantor DPMPTSP Kabupaten Karawang dalam memberikan pelayanan perizinan mendirikan bangunan belum berjalan dengan baik. Pertanyaan yang akan dibahas bagaimana karakteristik birokrasi pemerintahan dalam pelayanan perizinan IMB di DPMTPSP Kabupaten Karawang. Penulisan  ini menggunakan metode deskriptif dengan pendekatan kualitatif. Tujuan penulisan ini untuk mengetahui karakter birokrasi dalam pelayanan perizinan IMB di DPMPTSP Kabupaten Karawang. Teknik pengumpulan data yang dilakukan melalui studi pustaka dan studi lapangan berupa observasi serta wawancara dan dokumentasi. Hasil pembahasan menunjukan bahwa karakter birokrasi dalam pelayanan perizinan IMB di DPMPTPSP Kabupaten Karawang dilihat dari beberapa aspek. Pertama, keberadaan hirarkhi yang panjang dalam memberikan pelayanan perizinan IMB di DPMPTSP Kabupaten Karawang terdapat makna yang sama seperti yang di kemukakan oleh Max Weber dalam type birokrasi idealnya. Kedua, formalisasi aturan dan prosedur dalam birokrasi pelayanan perizinan IMB do DPMPTSP Kabupaten Karawang sebagaimana mencerminkan birokrasi type ideal Weberian yang menyatakan bahwa formalisasi diperlukan sebagai dasar bagi pengambilan keputusan seorang pejabat birokrasi dalam memberikan pelayanan agar pelayanan yang diberikan dapat cepat dan adil. Ketiga, debirokratisasi memangkas struktur dan prosedur birokrasi yang berbelit-belit untuk efisien dan efektivitas DPMPTSP Kabupaten Karawang melakukan debirokratisasi karena pelayanan perizinan sudah berlebihan dan melewati titik optimalisasi.
Extracorporeal Shock Wave Therapy for Lateral Epicondylitis, Lonely or in Combination with Topical Corticosteroid; Which Approach is Superior?
Authors: Vahdatpour Babak , Taheri Parisa , Abasi Fatemeh
Published: July 2020

Background: Lateral epicondylitis (LE) is a common musculoskeletal disorder. Although varieties of modalities have been proposed for its treatment, the outcomes are uncertain, and the responses would diminish early by the time passage. The current study was aimed to assess the efficacy of extracorporeal shock wave therapy (ESWT) merely and in combination with topical corticosteroid for the treatment of LE. Materials and Methods: In the current double-blinded randomized clinical trial, 70 patients with the diagnosis of LE were randomly allocated to two intervention groups of ESWT merely (control group) (n=35) or ESWT plus topical corticosteroid (intervention group) (n=35). The ESWT was performed weekly for three weeks. Topical clobetasol was utilized within 30 minutes before ESWT for the intervention group, while Vaseline gel was used in a similar pattern for controls. Pain based on a visual analog scale (VAS), handgrip strength (HGS) and the Patient-Rated Tennis Elbow Evaluation (PRTEE) were assessed for the patients before the intervention, following the intervention cessation, and within two months post-intervention. Results: Statistically significant improvement was found following both interventions in terms of pain, HGS, and function (P-value0.05). Conclusion: The findings of our study are in favor of ESWT use either merely or in combination with topical steroids for the treatment of LE, while the comparison of the two techniques revealed insignificant differences. [GMJ.2020;9:e1791]
Clinical applications of neurochemical and electrophysiological measurements for closed-loop neurostimulation
Authors: Price J. Blair , Rusheen Aaron E. , Barath Abhijeet S. , Rojas Cabrera Juan M. , Shin Hojin , Chang Su-Youne , Kimble Christopher J. , Bennet Kevin E. , Blaha Charles D. , Lee Kendall H. , Oh Yoonbae
Published: July 2020

The development of closed-loop deep brain stimulation (DBS) systems represents a significant opportunity for innovation in the clinical application of neurostimulation therapies. Despite the highly dynamic nature of neurological diseases, open-loop DBS applications are incapable of modifying parameters in real time to react to fluctuations in disease states. Thus, current practice for the designation of stimulation parameters, such as duration, amplitude, and pulse frequency, is an algorithmic process. Ideal stimulation parameters are highly individualized and must reflect both the specific disease presentation and the unique pathophysiology presented by the individual. Stimulation parameters currently require a lengthy trial-and-error process to achieve the maximal therapeutic effect and can only be modified during clinical visits. The major impediment to the development of automated, adaptive closed-loop systems involves the selection of highly specific disease-related biomarkers to provide feedback for the stimulation platform. This review explores the disease relevance of neurochemical and electrophysiological biomarkers for the development of closed-loop neurostimulation technologies. Electrophysiological biomarkers, such as local field potentials, have been used to monitor disease states. Real-time measurement of neurochemical substances may be similarly useful for disease characterization. Thus, the introduction of measurable neurochemical analytes has significantly expanded biomarker options for feedback-sensitive neuromodulation systems. The potential use of biomarker monitoring to advance neurostimulation approaches for treatment of Parkinson’s disease, essential tremor, epilepsy, Tourette syndrome, obsessive-compulsive disorder, chronic pain, and depression is examined. Further, challenges and advances in the development of closed-loop neurostimulation technology are reviewed, as well as opportunities for next-generation closed-loop platforms.