bluuebunny/crossref_metadata_2025 huggingface dataset:
Urgensi Legalitas Pelaksanaan Lelang Online Melalui Media Sosial Instagram
Authors: Putri Cut Maidina Ananda , - Sutiarnoto , Leviza Jelly , Kaban Maria
Published: February 2022

The implementation of auctions through Instagram social media often does not provide legal certainty for the parties participating in the auction because many in its implementation are not in accordance with the regulation of the Minister of Finance Number 213/PMK.06/2020 concerning auction implemention guidelines. So that in its implementation can cause disadvantage for the parties carrying out the auction.

            The research used descriptive analytical juridical normative method. Primary data and secondary data were obtained from library research and field research.

            The result of the research shows that the legal status of the Instagram account @usedbapeofficial was not an official auction house because it did not meet the requirements as an auction house, which should be in the form of limited liability company and obtaining permission form the Minister. Legal certainty for the owner of the goods has been carried out by @usedbapeofficial in the form of the payment proceeds being transferred to only one account, namely Kenneth Lee’s account as the account owner but does not provide legal certainty regarding when the owner of the goods will receive payment for the goods he auctions, legal certainty for the auction winner has been provides in the form of information that is listed in accordance with the format filled in by the owner of the goods. Legal protection for the owner of the goods is given in the form of holding funds in the @usedbapeofficial account until the goods are received by the buyer, while for the auction winner the legal protection is in the form of preventive and repressive legal protection.

            The conclusion of this research is the legal status of Instagram account @usedbapeofficial is not an official auction house. Legal certainty for the owner of the goods and the auction winner has not been fulfilled because most of the implementation of the auction on the Instagram account @usedbapeofficial do not comply with the provisions in the regulations of the Minister of Finance Number 213/PMK.06/2020 concerning auction implementation guidelines. Legal protection for the owner of the goods provided by @usedbapeofficial in the form of money auction sales is accommodated in one account, while legal protection for the auction winner has not been fully fulfilled because in its implementation legal protection is not provided by @usedbapeofficial in full to the injured party. It is recommended to @usedbapeofficial to improve the auction procedure into a buying and selling account with an auction mechanism and register its business as a Limited Liability Company, it is suggested to the government to update the regulations governing auction activities through social media, especially Instagram.
EKSEKUSI OBJEK JAMINAN FIDUSIA YANG TIDAK DIDAFTARKAN DAN AKIBAT HUKUMNYA BAGI KREDITUR (Studi Pada BRI Cabang Takengon dan PT. Mandala finance Cabang Takengon)
Authors: ARNILIS YANTI
Published: February 2022

The juridical consequence for a creditor who does not register his fiduciary collateral deed is that it is not protected by the Law No. 42/1999 on Fiduciary Collateral. The research problems are how about the legal consequence for a creditor who does not register his fiduciary object, how about the execution of unregistered fiduciary object in Bank BRI Takengon Branch and PT. Mandala Finance, and how about the obstacles encountered and efforts made by Bank BRI Takengon Branch and PT. Mandala Finance in the execution of the unregistered fiduciary object.

            The legal consequence for a creditor who does not register his fiduciary object is that the fiduciary object does not have any material rights for either Bank or financing companies as the creditor, the creditor does not have preference rights, the creditor does not have the rights to execute the fiduciary object and cannot request for protection to the police. What impedes Bank BRI Takengon Branch from conducting the execution is the provisions regulating that the minimum amount of a fiduciary object is IDR 50,000,000 (fifty million Rupiahs), the execution process takes much time, the fiduciary object is destroyed, the facility receiver name is different, the values of the fiduciary object is declined, and the debtor has different address. The impediment which is not included into a legal category is that the society has little understanding of fiduciary collaterals. The obstacles encountered by PT. Mandala Finance in the execution is that PT. Mandala Finance cannot make an execution because he has not registered the fiduciary object to the Fiduciary Collateral Office. The efforts made by BRI Takengon Branch is making an agreement; the execution is conducted by using an agreement of ownership right transfer of the object with trusts, by filinga simple lawsuit and re-registering the fiduciary object. The efforts that can be made by PT. Mandala Finance in the execution of the unregistered fiduciary object is by issuing Power of Attorney to grant the withdrawal authority and make negotiations with the debtor.
TINJAUAN YURIDIS PENERAPAN UNDANG-UNDANG NO.11 TAHUN 2012 TENTANG SISTEM PERADILAN ANAK, TERHADAP SANKSI PIDANA ANAK SEBAGAI PELAKU TINDAK PIDANA NARKOTIKA (STUDI KASUS PADA WILAYAH HUKUM PENGADILAN NEGERI LUBUK PAKAM No. 10/PID/SUS-Anak/2017/PN-LBP )
Authors: BR BARUS ERNAWATI
Published: February 2022

The child is a treasure God Almighty that is highly anticipated by a family, because aside from being a descendant of a family of children as well as the next generation of the nation and successor development, namely a generation that is prepared as a subject of implementing sustainable development and control the future of a country. As time goes by children not only as a victim in a crime but there have been many children involved as perpetrators of the crime, in this case was the crime of narcotics is one of the extraordinary crime or "extraordinary crime". Regulations governing the criminal justice system of children aims to protect the rights of the child. Based on the background, the author raised the Thesis entitled "Juridical Review the implementation of the law No. 11 Year 2012 On Child justice system, criminal sanctions against children as perpetrators of Crime Narcotics (case study on Pengadilam of State jurisdiction Lubukpakam No. 14/Pid. Child/Sus-2017/PN-LBP, no. 15/Pid. Sus-child/2017/PN-LBP and no. 32/Pid. Sus-child/2017/PN-LBPMetode research in this thesis is done with normative juridical research is to do an analysis of the problem through legal principles as well as referring to the legal norms contained in the legislation. The data used are sourced from primary and secondary legal materials through the library reseach using research data from a variety of sources such as legislation, reading books, and the internet are judged relevant to this thesis was elevated to discover sejauhmana the application of law number 11 Year 2012 against the perpetrators of the crime of narcotics on the State Court jurisdiction Lubukpakam.
PENGARUH INFERIORITY FEELING TERHADAP KECENDERUNGAN MELAKUKAN KEKERASAN DALAM BERPACARAN PADA DEWASA AWAL DI KARAWANG
Authors: Nopiyanti Sinta , Mubina Nuram , Simatupang Marhisar
Published: February 2022

Kecenderungan melakukan kekerasan dalam berpacaran bisa terjadi kepadasiapapun, baik itu laki-laki maupun perempuan. Individu yang memiliki tingkat inferiorityfeeling tinggi tentu akan mempengaruhi bagaimana individu tersebut berperilaku dalam suatuhubungan. Bentuk dari kecenderungan kekerasan dalam berpacaran adalah kekerasanpsikologis, kekerasan finansial, kekerasan seksual, dan kekerasan fisik. Tujuan dari penelitianini adalah untuk mengetahui pengaruh inferiority feeling terhadap kecenderungan melakukankekerasan dalam berpacaran pada dewasa awal di Karawang. Penelitian ini menggunakanmetode penelitian kuantitatif dengan teknik sampling snowball dan kuota. Partisipan padapenelitian ini adalah dewasa awal berusia 18-40 tahun, berdomisili di Karawang dan menjalinsuatu hubungan dengan pasangan. Jumlah partisipan dalam penelitian ini adalah sebanyak647 orang, dengan jumlah partisipan laki-laki sebanyak 378, dan perempuan sebanyak 269.Metode pengumpulan data dilakukan dengan bantuan google form yang disebar melaluisosial media. Alat ukur yang digunakan dalam penelitian adalah the feeling of inadecuacyscale dengan jumlah aitem 38, dan skala kecenderungan kekerasan dalam berpacaran denganjumlah aitem 66. Hasil penelitian menunjukkan bahwa inferiority feeling memiliki pengaruhsebanyak 28% terhadap kecenderungan melakukan kekerasan dalam dalam berpacaran padadewasa awal di Karawang.
PENGARUH KONFLIK PERAN GANDA TERHADAP STRES KERJA PADA PEREMPUAN BEKERJA DI PT HASIL RAYA INDUSTRI KARAWANG
Authors: Eliana Eliana , Siregar Linda Mora , Sadijah Nur Ainy
Published: February 2022

Tujuan dalam penelitian ini adalah untuk mengetahui seberapa tinggi tingkat streskerja, seberapa tinggi tingkat konflik peran ganda yang di alami dan juga untuk mengetahuiapakah terdapat pengaruh antara stres kerja dan konflik peran ganda pada perempuan bekerjaPT Hasil Raya Industri Karawang. Penelitian ini merupakan penelitian kuantitatif denganmetode pengambilan sampel nonprobability sampling dan jenis sampling menggunakanteknik sampling jenuh atau sensus dengan jumlah subjek sebanyak 159 orang. Teknik yangdigunakan untuk mengumpulkan data dalam penelitian ini adalah menggunakan kuesioneratau angket dengan skala likert. Hasil yang di dapatkan dalam penelitian ini adalah adanyapengaruh konflik peran ganda terhadap stres kerja pada perempuan bekerja di PT hasil rayaindustri karawang.
PENGARUH LAYANAN INFORMASI TERHADAP PENGETAHUAN SEKSUAL SISWA KELAS IPS 1 SMS NEGERI 6 BINJAI TAHUN PEMBELAJARAN 2010/2011
Authors: Lumbantoruan Haposan
Published: February 2022

Penelitian bertujuan untuk mengetahui pengaruh layanan informasi terhadap pengetahuan seksual siswa remaja di SMA Negeri 6 Binjai.Berdasarkan kajian teori terdapat perbedaan pengaruh tentang seksual pada saat sebelum dan sesudah diberikan layanan informasi pada siswa kelas IPS 1 SMA Negeri 6 Binjai Tahun Ajaran 2010 / 2011”.Penelitian yang digunakan adalah kuantitatif, tehnik Analisis Varians 1 Jalur, yakni pre test dan post test. Siswa yang tidak diberikan pre testdiberikan kode A1 dan yang diberi  pos test diberi kode A2. Sedangkan variable yang akan diukur atau variable terikatnya adalah pengetahuan seksual.Sampelnya 127 orang, hasil Analisis Varians 1 Jalur, maka diperoleh hasil sebagai berikut : a)Terdapat perbedaan pengetahuan seksual yang sangat signifikan antar siswa sebelum dan sesudah diberikan layanan informasi tentang seksual dengan Anava F  =  117,914 dengan koefisien signifikan 0,000 artinya nilai signifikan yang diperoleh lebih kecil dari 0,010. Ada perbedaan pengetahuan seksual antar siswa sebelum dan sesudah diberikan layanan informasi tentang seksual, diterima.b)Diketahui bahwa setelah diberi layanan informasi tentang seksual memiliki pengetahuan seksual yang lebih tinggi dengan nilai rata-rata 144,688 dibandingkan dengan sebelum diberikan layanan informasi tentang seksual dengan nilai rata-rata 109,288. Ini berarti layanan informasi yang dilakukan peneliti memberikan pengaruh yang sangat berarti bagi remaja dalam memahami segala hal yang berkaitan dengan seksual. c)Bahwa para siswa SMA Negeri 6 Binjai , yang sedang duduk di tahun ajaran 2010 / 2011 memiliki pengetahuan seksual pada kategori tinggi, sebab mean empiric (128,9889) selisihnya dengan nilai rata-rata hipotetik (110) melebihi nilai SD yakni 23,521.
Перспективи ноогуманізму у світі без пандемій і колапсів
Authors: Кірик Тамара
Published: February 2022

Прихід пандемії COVID-2019 є свідченням виразного загострення стосунків людства і довкілля. Ми усі зобов’язані знайти нові шляхи для вирішення кризових проблем людства на основі розвитку сукупності природничих і гуманітарних наук. Серед перспективних засобів – застосування в сучасних умовах забутого поняття "неогуманізм" та удосконаленої філософії освіти. Досліджено також сучасну тенденцію появи нових наукових термінів, які пов'язані з поняттям "ноосфера". Вони потрібні для опису інновацій у вищій освіті, наукових досліджень на виробництві, в управлінні, екології та ін. Нові терміни формують ноолексикон. У статті наведено авторський варіант ноолексикону для вищої школи ХХІ ст. і вказано на особливо велике значення поняття "ноогуманізм" для всієї діяльності людства у пост-пандемічному світі.
Трипільський ритуальний календар з простору Небелівського Храму
Authors: Завалій Олександр
Published: February 2022

В статті розглядається ймовірний астрономічно-календарний артефакт з групою фішок до нього, які були знайдені під час археологічних розкопок Трипільського Храму поблизу с. Небелівка, Кіровоградської області. Такі знахідки були зосереджені в західній частині храмового комплексу в районі ритуального вівтаря вогню. Основна увага зосереджується на питанні реконструкції знахідок та смислового базису Небелівського Диску. Виявлені особливості, які ймовірно вказують на ведення адміністративної практики в просторі Небелівського Храму та ритуальних дій, пов’язаних з календарним циклом. Аналізуються праці Михайла Відейка, Наталії Бурдо, Євгена Причепія та інших науковців, у яких мовиться про уявлення трипільців про календарно-астрономічні цикли. Досліджуються відомості про календарні уявлення інших стародавніх цивілізацій. З цим Небелівський ритуальний храмовий "Диск" проявляє себе в закономірностях існуючих світових культових предметів календарного призначення.
The Issue of Indirect Meaning: On the Rhetorical Modifications in Fine Arts
Authors: Вячеславова Олена
Published: February 2022

The article proposes to adapt the experience of rhetorical understanding of the text to the aesthetic issues of trope in the fine arts. Differentiating the rhetoric of figures and the rhetoric of the text as a whole, author proves the determination of the rhetorical (poetic) function in the fine arts as a means of self-detection of work’s artistic language involved in creation of meaning and as a set of operations leading to the semantic changes and to the integration of text semantics. Significance of metalogism as a type of rhetorical transformation in the fine arts has been revealed. A thesis that the category of visual metalogisms includes operations associated with the deviations from visual perceptual and logical codes present in a work, which is the specificity of the fine art systems of the modern art, has been put forward. Regarding the analysis of metalogisms, author concludes that the refusal from the principles of mimesis, the reduction of the optical illusion and the beginning of scene, which were typical for the art of the late nineteenth and twentieth centuries, are the ways to realize poetic (rhetorical) function of language in the fine arts. The article reveals the functional heterogeneity of the various types of intertextual relations, suggested by the rhetoric of text. It has been accented that one of the sources, that generate indirect meanings in art, is a communicative situation, given by the presence of the centers of semantic uncertainty in a work and leading to activation of autocommunication acts. Taking into account the distinguishing between linguistic and extralinguistic symbolism, the proposed model can become a methodological basis for the differentiation of historical types of symbolism in art, including non-classic specific for art.
FORMATION OF STREAMSIDES OF URBAN AND RURAL SETTLEMENTS IN THE ASPECT OF LEGAL CITY REGULATION
Authors: Baklazhenko E.
Published: February 2022

The problems of the formation and development of streamsides have long attracted researchers from different scientific communities. Modern anthropogenic impact leads to ecological degradation and deterioration of the state of water bodies, as well as adjacent territories. So, the need to establish water protection zones is an important step towards sustainable development and protection of water bodies. The paper deals with the process of establishing and formalizing water protection zones. The water legislation of the Russian Federation, which regulates water protection relations, was studied. The legal regime of economic activity and the possible form of ownership of territories in the framework of water protection zones were analyzed. Measures were proposed to protect surface water bodies and improve the use of streamsides from an environmental and legal point of view.
«GEOGRAPHICAL» DESIGN. TRAVELER ROAD KIT
Authors: Svalov M.
Published: February 2022

The article presents the key milestones in the development of navigation tools of the first territory researchers. The main inventions and discoveries that directly or indirectly influenced the formation of the entire historical, cultural and geographical world are presented. Tools for tracking own location (with astrolabe, sextant, planisphere, lighthouse), external changing factors, and physical phenomena (with compass, chronometer) are studied not only from the point of view of historical retrospective but also as key milestones that have become the starting points for the development of subject, environmental and graphic design. At the same time, the article is a cultural section of folklore and mythology/ It represents a look at the basics of the traditional formation of peoples of different geographical locations and national composition. On the example of a number of unique specific objects, the connection of the past with the environment of modern man is demonstrated. The article clearly shows the cause-effect relationships between the first inventions and tools related to orientation in space and modern technologies. The influence of various scientific and technical aspects on the formation of a platform for the formation of a digital society of the future is shown. All of the above allows formulating a hypothesis and predicting how navigation will develop in real and virtual space in the future and what will serve as a source of inspiration for it.
Macrophage Membrane-Camouflaged shRNA and Doxorubicin: A pH-Dependent Release System for Melanoma Chemo-Immunotherapy
Authors: Yang Chengli , Ming Yang , Zhou Kai , Hao Ying , Hu Danrong , Chu Bingyang , He Xinlong , Yang Yun , Qian Zhiyong
Published: February 2022

Improving the efficacy of melanoma treatment remains an important global challenge. Here, we combined chemotherapy with protein tyrosine phosphatase nonreceptor type 2(Ptpn2) based immunotherapy in an effort to address this challenge. Short-hairpin RNA (shRNA) targeting Ptpn2 was coencapsulated with doxorubicin (DOX) in the cell membrane of M1 macrophages (M1HD@RPR). The prepared nanoparticles (NPs) were effectively phagocytosed by B16F10 cells and M1 macrophages, but not by M0 macrophages. Hence, NP evasion from the reticuloendothelial system (RES) was improved and NP enrichment in tumor sites increased. M1HD@RPR can directly kill tumor cells and stimulate immunogenic cell death (ICD) by DOX and downregulate Ptpn2. It can promote M1 macrophage polarization and dendritic cell maturation and increase the proportion of CD8
+
T cells. M1HD@RPR killed and inhibited the growth of primary melanoma and lung metastatic tumor cells without harming the surrounding tissue. These findings establish M1HD@RPR as a safe multifunctional nanoparticle capable of effectively combining chemotherapy and gene immunotherapies against melanoma.
Сучасні тенденції розвитку танкових лазерних далекомірів
Authors: Федоренко Артем Вячеславович , Рижих Василь Миколайович , Маслов Володимир Петрович
Published: February 2022

В статті розглянуто тенденції розвитку танкових лазерних далекомірів. Предметом дослідження є лазерний далекомір.  Метою роботи є визначення сучасних тенденцій в розробці лазерних далекомірів та додаткових вимог, пов’язаних з  маскуванням танків в ІЧ-діапазоні, котрі потребують вирішення.Проаналізовано існуючі танкові лазерні далекоміри в сучасних системах прицілювання та визначено тенденції вибору їх  робочої довжини хвилі і основних приладових компонентів імпульсних лазерів та швидкодіючих фото-приймачів. Обґрунтовано перспективність використання джерела лазерного випромінювання з діодною накачкою та робочою  довжиною хвилі 1,54 мкм. Результати роботи можна застосувати в галузі оптоелектроніки, зокрема, для створення лазерних далекомірів.
Context, Culture, and the Complexity of De-Implementing Low-Value Care Comment on "Key Factors that Promote Low-Value Care: Views of Experts From the United States, Canada, and the Netherlands"
Authors: Sypes Emma E. , Leigh Jeanna Parsons , Stelfox Henry T. , Niven Daniel J.
Published: February 2022

Low-value care contributes to poor quality of care and wasteful spending in healthcare systems. In Verkerk and colleagues’ recent qualitative study, interviews with low-value care experts from Canada, the United States, and the Netherlands identified a broad range of nationally relevant social, system, and knowledge factors that promote ongoing use of low-value care. These factors highlight the complexity of the problem that is persistent use of low-value care and how it is heavily influenced by public and medical culture as well as healthcare system features. This commentary discusses how these findings integrate within current low-value care and de-implementation literature and uses specific low-value care examples to highlight the importance of considering context, culture, and clinical setting when considering how to apply these factors to future de-implementation initiatives.
Interrogating Business and Public Administration Research Attributes and Variables
Authors: Wotela Kambidima
Published: February 2022

Research proposal presentation or assessment panels and ethics assessment committees almost always ask us why we have included certain questions in our data or information collection instruments as well as why we think such questions will help us realise our research purpose. How can we answer these questions? First, let us step back. Numerous books have described what a conceptual framework is and why we need it. Further, there are several attempts to describe how we can conceptualise conceptual frameworks primarily through reviewing literature. One of the sets of literature that we should review is on attributes or variables, if not both, that are key to the research that we are pursuing. However, we find the discussion on how we should interrogate literature on attributes or variables not exhaustive to adequately guide a research student or a research novice on what they should do. Therefore, this paper proposes how we should explicitly identify, interrogate, and integrate literature on qualitative attributes or quantitative variables that are key to our business and public administration research. Apart from summoning basic systems thinking principles, the paper draws on reverse engineering comments compiled from examiners’ reports[1] and consequent discussions with colleagues and students through devising seminars. We believe that the approach we have proposed in this paper will guide business and public administration research students and novices on how they should interrogate literature on attributes or variables that are key to the research that they are pursuing. If they get this right, it would contribute to robustness of their conceptual framework and, therefore, the research report. Before then, it will also empower us to answer the research proposal presentation or assessment panels and ethics assessment committees on why we have included certain questions in our data or information collection instruments and why we think such questions will allow us to achieve our research objectives.

[1]Examiner’s reports of some WITS Graduate School of Governance and WITS Graduate School of Business Administration students.
Auditory Function of Newborns Born to Mothers Who Have Suffered COVID-19
Authors: Богомильский М.Р. , Рахманова И.В. , Матроскин А.Г. , Зашляхин А.Р. , Арютина П.С.
Published: February 2022

Настоящая статья представляет собой обзор клинических данных зарубежных, отечественных авторов и собственных наблюдений для более четкого понимания особенностей течения COVID-19-инфекции. Затрагиваются такие проблемы, как путь передачи SARS-CoV-2 от матери к ребенку, а также возможность и пути влияния на слуховую функцию у детей при рождении. В статье приведены данные собственных исследований 14 детей, рожденных от матерей, перенесших COVID-19 во время беременности. При исследовании у 10 детей была выявлена нейросенсорная тугоухость различной степени и глухота, а у 4 детей слуховая функция была в пределах нормы. На основании вышеизложенного считаем необходимым и целесообразным дальнейшее изучение пути и возможности передачи вируса SARS-CoV-2 от матери к плоду, а также проведение динамического аудиологического исследования в течение первого года жизни всем детям, рожденным от матерей, перенесших COVID-19.

This article is a review of the clinical data of Russian and foreign authors and our own observations for a clearer understanding of the course features of COVID-19 infection on auditory function of newborns. The problems such as the mother-to-child transmission of SARS-CoV-2, as well as the possibility and ways of influence on auditory function in children at birth are described. The article indicates the data of our own studies of 14 children born to mothers who had COVID-19 during pregnancy. During the study, 10 children showed neurosensory hearing loss of various degrees and deafness. Four children had auditory function within the limits of the norm. Based on their own observations, the authors of the article consider it necessary to study further the path and possibility of transmission of the virus SARS-CoV-2 from mother to fetus, as well as to conduct a dynamic audiological study during the first year of life for all children born to mothers who have suffered COVID-19.
Antioxidant Effect of Benphothyamine in the Retina and Optic Nerve Tissues of Rabbits with Experimental Glaucoma (Ophthalmohypertension) on the Background of Streptosotocin Diabetes
Authors: Юревич В.Р. , Михейцева И.Н.
Published: February 2022

Изучили влияние жирорастворимой формы витамина В1 бенфотиамина (БФТ) на маркеры оксидативного повреждения биомолекул (МДА и СО-группы) и активность антиоксидантных ферментов (СОД, каталаза, глутатионпероксидаза) сетчатки и зрительного нерва при экспериментальной глаукоме на фоне стрептозотоцинового диабета у кроликов. Глаукому воспроизводили введением метилцеллюлозы в переднюю камеру глаза. БФТ вводили per os 50 мг в сутки (дважды в день по 25 мг) на протяжении 2 месяцев. Получен выраженный метаболический эффект БФТ при моделировании глаукомы на фоне диабета у кроликов. В нервных тканях глаз животных этой группы уровень маркеров свободнорадикального окисления МДА и карбонильных групп белков снижался, а активность антиоксидантных ферментов первой линии защиты повышалась под влиянием курсового введения липофильной формы витамина В1. Это свидетельствует о протекторном действии этого препарата на сетчатку и зрительный нерв при окислительном стрессе, что может явиться обоснованием применения жирорастворимой формы витамина В1 в качестве нейропротекторного средства при лечении пациентов с первичной глаукомой, особенно сопровождающейся сахарным диабетом.

We studied the effect of the fat-soluble form of vitamin B1 benfotiamine (BFT) on markers of oxidative damage to biomolecules (MDA and CO groups) and the activity of antioxidant enzymes (SOD, catalase, glutathione peroxidase) of the retina and optic nerve in experimental glaucoma against the background of diabetic streptozotocin in rabbits. Glaucoma was reproduced by introducing methylcellulose into the anterior chamber of the eye. BFT was administered per os 50 mg per day (twice a day at 25 mg) for 2 months. A pronounced metabolic effect of BFT was obtained in modeling glaucoma and diabetes in rabbits. The level of free radical oxidation markers (MDA and carbonyl groups of proteins) was decreased, whereas the activity of antioxidant enzymes of the first line of defense was increased under the influence of course administration of the lipophilic form of vitamin B1 in the nerve tissues of the rabbit’s eyes with diabetes and glaucoma. This indicates the protective effect of BFT on the retina and optic nerve during oxidative stress, which may justify the use of the fat-soluble form of vitamin B1 as a neuroprotective agent in the treatment of patients with primary glaucoma, especially those accompanied by diabetes mellitus.
Olanzapine: Modern Application Concepts
Authors: Мангуби В.А.
Published: February 2022

В статье рассматриваются особенности применения оланзапина как антипсихотического препарата в психиатрии, а также пути возможной коррекции метаболического синдрома, ассоциированного с применением атипичных антипсихотиков, использование оланзапина в качестве антиэметогенного средства и как адъюванта при лечении анорексии, которые частично носят экспериментальный характер и находятся на стадии изучения и внедрения.

The article examines the features of the use of olanzapine as an antipsychotic drug in psychiatry. Also, ways of possible correction of metabolic syndrome associated with the use of atypical antipsychotics. The use of olanzapine as an antiemetic agent and as an adjuvant in the treatment of anorexia, which is partially experimental in nature and is under study and implementation.
UHF Bandı Haberleşme Sistemleri İçin Çoklu Frekans Maruziyeti Etkilerinin İncelenmesi
Authors: ZORLU Elgin , ALAGÖZ İzzet , ELMAS Bahadır
Published: February 2022

Elektromanyetik radyasyon; evlerimizde, iş yerlerimizde, toplu taşıma araçlarında ve kalabalık sosyal etkinliklerde çevremizi bizimle paylaşan bir unsurdur. Bu durum baz istasyonlarından, mobil telefonlardan, kablosuz yerel alan ağ cihazlarından veya Radyo-Televizyon vericilerinden kaynaklanabilir. Elektromanyetik radyasyonun insan vücuduna olan etkilerini hesaplayabilmek için bu radyasyonun ne kadarının insan vücudu tarafından emildiğinin bilinmesi gereklidir. Bunun için de elektromanyetik radyasyon yayan kaynakların Özgül Emilim Oranı olarak bilinen değerleri hesaplanmalıdır. Bu çalışmada, insanların günlük yaşamda vakitlerini geçirdiği ortamlarda, cep telefonlarından, kablosuz modemlerden, bilgisayarların üzerindeki kablosuz yerel alan ağ erişim kartlarından ve Bluetooth sistemlerden kaynaklanan elektromanyetik radyasyona maruz kalan insanlar üzerinde oluşan elektriksel alanlar, tek kullanıcı ve kalabalık ortamlar için benzetimler yapılarak senaryolaştırılmış ve bu senaryolar gereği insanlar üzerindeki toplam elektriksel alan değeri hesaplanarak, uluslararası standartlar ile belirlenmiş emniyetli maruziyet sınırları ile karşılaştırılmıştır. Elde edilen bu elektriksel alan değerleri kullanılarak da insan beyin sıvısındaki elektromanyetik radyasyon soğurulma miktarları ile maruziyet süresince beyin sıvısında meydana gelen sıcaklık artışları hesaplanmış ve sonuçlara ulaşılmıştır.
La custodia compartida en las relaciones familiares en conflicto
Authors: Garay Molina Ana Cecilia
Published: February 2022

Dos de los conflictos familiares que más afectan a los hijos son la violencia familiar y la separación de los padres (sean casados o no); en estos casos, surge la necesidad de decidir cuál de ellos ejercerá la custodia de los hijos menores de edad o si recaerá en ambos. Gracias a la fórmula de la custodia compartida, la cual analizamos en este trabajo, los hijos pueden tener un mayor disfrute de la presencia y los cuidados de ambos padres, quienes poseen las mejores condiciones para definir el régimen de custodia más apropiado para sus hijos, de acuerdo con sus circunstancias particulares. El ejercicio de la custodia compartida a cargo de los padres separados es más eficaz si han llegado a un acuerdo.

El juez ratificará o no el acuerdo de los padres según lo considere o no idóneo para el bienestar del niño, la niña o el adolescente, pues la tendencia debe regirse por el mayor beneficio de los hijos y no por un sentido de justicia o equidad hacia los padres.
Presentación
Authors: Cupe Calcina Eloy Marcelo
Published: February 2022

Nos complace presentar el cuarto número de Ius Vocatio. Revista de Investigación de la Corte Superior de Justicia de Huánuco, un órgano intelectual que, a lo largo de estos cuatro años, no ha detenido su continuidad ni mermado su calidad académica y rigurosa, a pesar de las dificultades contextuales que la Corte Superior de Justicia de Huánuco, el Poder Judicial y el país, en general, han enfrentado, especialmente en este 2021, segundo año en que la pandemia por la COVID-19 azota sin clemencia a nuestras familias. Sin embargo, nuestro compromiso profesional nos ha impulsado a desempeñar con eficiencia nuestras funciones en la judicatura y, sobre todo, en esta noble misión de difundir los trabajos académicos de nuestros servidores judiciales, promoviendo la investigación en los distintos ámbitos del derecho.
El razonamiento indiciario para probar los estados mentales. La realidad psicológica del dolo a través de indicios
Authors: Mendiguri Peralta David Rosario
Published: February 2022

El presente trabajo expone las concepciones normativas y psicológicas sobre la prueba de estados mentales. Se decanta por la última y se sustenta que un caso de feminicidio pone a prueba el razonamiento indiciario para verificar el sustrato psicológico del dolo: finalidad típica.
Professor of the department of Hygiene and medical police of the Saint Vladimir university in Kiev Vladimir Dmitrievich Orlov (1856-1915)
Authors: Vasyliev Yu.K.
Published: February 2022

For the first time, the article examined the life and work of a prominent representative of preventive science before the Soviet period in Ukraine, Vladimir Dmitrievich Orlov. Two periods of his scientific and pedagogical activity that are approximately the same in duration are distinguished, i. e. the Kazan and Kiev periods. In Kazan, he received a higher medical education, formed as a scientist and teacher (1873–1893); and in Kiev, he was further formed as a man of science, no longer an assistant, laboratory assistant and assistant professor, but Professor (since 1893). At the St. Vladimir University, where Professor V.D. Orlov headed the Department of Hygiene and Medical Police (1893–1914), he first introduced practical classes (1894) and visits by students to sanitary institutions in Kiev (1895). He prepared and published "A Guide to Practical Training in Hygiene and Medical Police" (1905). In the Russian Empire V.D. Orlov was Professor-hygienist of the second generation and in teaching he devoted much to the issues of Experimental Hygiene, and less to the second faculty discipline, which was assigned to his Department, i. e. Medical Police. Dissertation work came out for the first time from the Department of Hygiene and Medical Police led by Professor V.D. Orlov. In 1912, a supernumerary assistant of the Department Yaroslav Ventselevich Rezhabek (1865–1943) defended his thesis for the degree of Doctor of Medicine; in 1913 a supernumerary assistant of the Department Leonid Orestovich Dubitsky (1865–1931), being a student of Professor Orlov, prepared a dissertation research at the Würzburg Professor K.B. Lehmann. For the first time at the Department under Professor Orlov student scientific work began to be carried out and some of them were awarded gold (Mikhail Yasnikov, 1896; Alexey Filov, 1899; Vladislav Marzhetsky, 1900; Nikolai Posudzevsky, 1903) and silver (Anatoly Vasyutinsky, 1896) medals.

Keywords: hygiene, medical police, teaching, Kiev, Ukraine, the Russian Empire.
Pengaruh Edukasi Deteksi Dini Stroke dengan Metode Fast Terhadap Tingkat Pengetahuan Keluarga dengan Risiko Tinggi Stroke di Wilayah Kerja Puskesmas Suwawa Kabupaten Bone Bolango
Authors: Zulkifli
Published: February 2022

Deteksi dini merupakan pemeriksaan yang dilakukan pada orang yang belum menunjukkan adanya gejala penyakit untuk menemukan penyakit yang belum terlihat atau masih pada stadium praklinik. Metode yang dapat dilakukan untuk mendeteksi dini stroke adalah dengan metode FAST.

Tujuan penelitian ini yakni ntuk mengetahui pengaruh edukasi deteksi dini stroke dengan metode FAST terhadap tingkat pengetahuan Keluarga dengan risiko tinggi Stroke di Wilayah Kerja Puskesmas Suwawa Kabupaten Bone Bolango. Metode: metode kuantitatif dengan disain quasi experiment berupa pre test and post test nonequivalent control group. Penelitian ini menggunakan non probability sampling dengan sampel 34 responden. Instrumen yang digunakan adalah kuesioner tingkat pengetahuan.

Hasil penelitian didapatkan sebelum diberikan edukasi deteksi dini stroke dengan metode FAST yakni dengan kategori baik sejumlah 3 responden, setelah diberikan edukasi deteksi dini stroke dengan metode FAST yakni terjadi peningkatakan dengan kategori baik sejumlah 13 responden. Kesimpulan: Ada pengaruh edukasi deteksi dini stroke dengan metode FAST terhadap tingkat pengetahuan Keluarga dengan risiko tinggi Stroke di Wilayah Kerja Puskesmas Suwawa Kabupaten Bone Bolango. Saran penelitian selanjutnya perlu adanya pengingkatan sistem dalam penanganan pasien stroke di tahap pra hospital.

 

Kata Kunci : Edukasi, FAST, Deteksi Dini, Stroke, Pengetahuan
Tumor fibroso solitario gigante de pleura
Authors: Pérez Palenzuela Javier , Pérez García Kymani
Published: February 2022

Objetivo: Reportar el caso de una masa gigante en hemitórax izquierdo de 19 cm de diámetro en un paciente de 59 años que debutó con disnea, tos y dolor torácico, confirmándose por estudio imagenológico. Material y Método:  Registro clínico de un paciente al cual se le diagnostica tumor fibroso solitario de pleura, siendo intervenido quirúrgicamente para exéresis de la lesión. Resultados: Se realiza toracotomía posterolateral izquierda para exéresis de tumor gigante, requiriendo además resección de diafragma y pericardiectomía parcial con evolución favorable. Discusión: El tumor fibroso solitario es una neoplasia rara derivada del mesénquima que afecta más comúnmente a la pleura, típicamente bien circunscrita, pediculada, con vasos dentro del pedículo tumoral, pudiendo llegar a ser de gran tamaño, siendo considerados gigantes cuando tienen más de 15cm de diámetro. Conclusión: El diagnóstico correcto es de vital importancia, ya que con la resección quirúrgica es potencialmente curable. El tratamiento quirúrgico puede efectuarse por toracotomía o videotoracoscopia, dependiendo del tamaño del tumor. A pesar del comportamiento benigno, requiere seguimiento a largo plazo debido a la tendencia a la recidiva.
Recovery of potential-induced degraded p-type multicrystalline Si PV modules by application of a reverse DC bias
Authors: Huai Go Sian , Takada Kiyoshiro , Ono Kota , Hashimoto Shingo , Htun Naing Lin , Ohashi Fumitaka , Yoshida Norimitsu , Sobajima Yasushi , Nonomura Shuichi
Published: February 2022

Potential-induced degradation (PID) of photovoltaic (PV) modules based on p-type crystalline Si occurs in large-scale PV systems. The development of a low-cost PID recovery technique is important to maximize the power generation capacity of PID-affected facilities. In this paper, we study a simple PID recovery method for multicrystalline silicon solar cells. PID recovery was conducted by application of a reverse DC-bias voltage to the p-n junction of solar cells in PV modules, without temperature control devices. By using this method, the conversion efficiency of solar cells reduced to approximately 20% of their initial value via a PID test was recovered up to 92%. Additionally, nonuniform temperature increases of PV modules by leakage current were observed during the voltage application.
Effect of three different doses of intrathecal dexmedetomidine on subarachnoid block: a prospective randomized double-blind trial
Authors: Mowar Ashita , Singh Vishwadeep , Pahade Akhilesh , Karki Geeta
Published: February 2022

Background: Dexmedetomidine has increasingly been used in regional anesthesia as an adjuvant, but there is still no consensus on the optimum dose when it is used intrathecally. We conducted this study to elucidate the dose-response relation between three different doses of intrathecal dexmedetomidine (2.5, 5, or 10 µg) as an adjuvant to 0.5% hyperbaric bupivacaine in patients undergoing elective lower abdominal and lower limb surgeries.

Methodology: 90 patients, aged 18-60 y, were randomized into three groups of 30 patients each. Group A received 0.5% hyperbaric bupivacaine 12.5 mg (2.5 ml) with 2.5 µg dexmedetomidine, Group B received 5 µg dexmedetomidine with bupivacaine, and Group C received 10 µg dexmedetomidine with bupivacaine. Duration of the spinal sensory blockade (primary outcome), onset of the blockade, time to rescue analgesia, level of sedation, duration of motor blockade, comparison of hemodynamic variables and complications, if any were assessed.

Results: There was a significant dose dependent prolongation of sensory block; Group A - 250.67 ± 51.39, Group B - 286 ± 52.76, and Group C - 351.00 ± 47.00 min; (p < 0.001), motor block; Group A - 255.53 ± 44.25, Group B - 312 ± 29.64, and Group C - 361.4 ± 16.14 min (p < 0.001). Time to two segment regression was 132.33 ± 48.29, 148.77 ± 48.89, 171.57 ± 25.46 min (p = 0.002) and time for rescue analgesia was 351.33 ± 101.19, 472.00 ± 24.41, 738.00 ± 67.79 min (p < 0.001). VAS was significantly low in Group C (p < 0.05). Intergroup hemodynamic parameters were comparable (p > 0.05) without any appreciable side effects.

Conclusion: Spinal dexmedetomidine increases the sensory and motor block durations as well as time to first analgesic use, and decreases analgesic consumption in a dose-dependent manner, when used with hyperbaric bupivacaine.

Abbreviations: IT - Intrathecal; ITD - Intrathecal Dexmedetomidine; SAB - Subarachnoid Block; VAS - Visual Analogue Scale; BMI - Body Mass Index; NIBP - Non-Invasive Blood Pressure; RSS - Ramsay Sedation Score; TSSR - Two segment sensory regression; ANOVA - Analysis of Variance; OSB - Onset of sensory block, TSSRT - Two segment sensory regression time; Duration of sensory blockade; OMB - Onset of motor block; DMB - Duration of motor blockade

Key words: Dexmedetomidine; Bupivacaine; Anesthesia, Spinal; Dexmedetomidine; Post-operative analgesia

Citation: Mowar A, Singh V, Pahade A, Karki G. Effect of three different doses of intrathecal dexmedetomidine on subarachnoid block: a prospective randomized double-blind trial. Anaesth. pain intensive care 2021;26(1):8–13;

DOI: 10.35975/apic.v26i1.1759

Received: July 24, 2021, Reviewed: November 18, 2021, Accepted: November 28, 2021
An online study of knowledge and practices of local anesthetic systemic toxicity among doctors in Sri Lanka
Authors: Munasinghe B. M. , Subramaniam Nishanthan , Srisothinathan Nimalan , Jayamanne B. D. W.
Published: February 2022

Background: Inadvertent over-dosage or intravascular injections may still lead to systemic toxicity. Local anesthetic systemic toxicity (LAST) could be potentially life threatening. This study focused on the current knowledge and practices in use of LA by the doctors in Sri Lanka and their ability to detect and manage an event of LAST.
Methodology: A descriptive cross-sectional study was conducted among doctors in Sri Lanka using an online self-administered questionnaire based on AAGBI guidelines (2010). Descriptive statistics were analyzed by cross-tabulations and presented as numbers and percentages using IBM-SPSS 25.
Results: The response rate was 60% out of 600 doctors. Majority were males (58%) while 45% of the respondents were anesthetists. Ultrasound was used by 47.4% during specific LA use. The majority (74%) considered total body weight for dose calculations. Around 50% of the respondents identified bupivacaine as the most cardiotoxic. The majority (77%) utilized some form of monitoring and were knowledgeable on identification, prevention and initial management of LAST. Approximately 45% identified Intralipid (ILE) as the definitive treatment of LAST, out of which, 66.8% knew the correct dose, 77.2% and 26.5%, the availability and the location of the stored drug, respectively.
Conclusion: The basic knowledge about LAST was satisfactory among the respondents. A statistically significant difference on knowledge on maximum safe doses of LA, ILE in established LAST, its dosage and the availability was identified between anesthetists and non-anesthesia doctors; and postgraduate trainees and the rest of the doctors. Overall, significant lapses were noted with regard to the use of total body weight for dose calculations, use of ultrasound during LA administration and dosage, availability and storage of the definitive therapy and ILE.
Abbreviations: LA - Local anesthetics; LAST - Local anesthetic systemic toxicity; ILE - Intralipid
Key words: Local Anesthetic Systemic Toxicity; LAST, cardiac toxicity, Intralipid
Citation: Munasinghe BM, Subramaniam N, Srisothinathan N, Jayamanne BDW. An online study of knowledge and practices of local anesthetic systemic toxicity among doctors in Sri Lanka. Anaesth. pain intensive care 2022;26(1):69-74.
DOI: 10.35975/apic.v26i1.1770
Received: August 27, 2021, Reviewed: October 05, 2021, Accepted: October 10, 2021
Comparison of propofol and ketofol for sedation in patients undergoing shoulder surgery with interscalene and suprascapular nerve blocks
Authors: Akcaalan Yasemin , Sahap Mehmet , Gulec Handan , Horasanli Eyup , Ugurlu Mahmut , Akcaalan Serhat
Published: February 2022

Introduction and Purpose: We compared propofol and ketofol for sedation in patients who underwent shoulder arthroscopy under anesthesia with interscalene and suprascapular blocks. We evaluated both of agents the intraoperative hemodynamic effects, sedation efficiency, postoperative recovery times and the time to discharge to the service. We aimed to achieve an effective sedation with stable hemodynamics, resulting in rapid recovery with early onset.

Methodology: The study was carried out prospectively in a double-blind randomized study on ASA I and II patients aged 18-65, total of 42 shoulder surgeries planned. Anesthesia was provided to the patients by performing interscalene and suprascapular nerve block with USG. Group 1 (Propofol group), 1 mg/kg propofol iv, in Group 2 (Ketofol group), a mixture of ketamine-propofol was prepared in a 1:1 ratio, 1 mg / kg ketofol iv was administered. Processing was started in both groups when Ramsey Sedation Scale (RSS) was 3. SBP, DBP, MBP, heart rate, O2 saturation, RSS, Faces scale were recorded throughout the case. The patients with an Aldrete score of 9 were discharged and sent to the service.

Results: A total of 42 patients undergoing planned shoulder surgeries were enrolled. No statistically significant was determined between the groups in respect of demographic data (age, gender, height, weight, ASA), operating time and postoperative length of stay in hospital. More patients required esmolol in the ketofol group compared to propofol group; 15 (71.4%) vs. 7 (33%) patients (p < 0.05). Significant higher mean values of hemodynamic findings in the ketofol  group were noted; SBP at 55 min, DBP at 60 min, MBP at 60 min and MBP on discharge (p < 0.05). In the absence of esmolol, the pulse measurements at 0, 1, 3, 25, and 30 min were determined to be statistically significantly higher in the ketofol group than the propofol group (p < 0.05). The mean values of the SpO2 measurements were significantly lower in the ketofol group (p < 0.05). No statistically significant difference was determined in respect of the postoperative modified Aldrete Scores (MAS) at any of the time points (p > 0.05).

Conclusion: While a deeper and higher quality sedation was provided with ketofol, we achieved rapid onset and short-acting sedation with propofol. Both agents have different superior properties and can be used safely for sedation.

Key words: Brachial plexus block, ketofol, shoulder arthroscopy, propofol, sedation

Citation: Akcaalan Y, Sahap M, Gulec H, Horasanli E, Ugurlu M, Akcaalan S. Comparison of propofol and ketofol for sedation in patients undergoing shoulder surgery with interscalene and suprascapular nerve blocks. Anaesth. pain intensive care 2022;26(1):102-109.

DOI: 10.35975/apic.v26i1.1775

Received: September 24, 2021, Reviewed: October 18, 2021, Accepted: Nov 09, 2021