bluuebunny/crossref_metadata_2025 huggingface dataset:
Molecular docking analysis of novel quercetin derivatives for combating SARS-CoV-2
Authors: Marashdeh Mohammad
Published: March 2023

Quercetin belongs to the flavonoid family, which is one of the most frequent types of plant phenolics. This flavonoid compound is a natural substance having a number of pharmacological effects, including anticancer and antioxidant capabilities, as well as being a strong inhibitor of various toxicologically important enzymes. We discuss the potential of newly recently synthesized quercetin-based derivatives to inhibit SARS-CoV-2 protein. ADMET analysis indicated that all of the studied compounds had low toxicities and good absorption and solubility properties. The molecular docking results revealed that the propensity for binding to SARS-CoV-2 main protease is extraordinary. The results are remarkable not only for the binding energy values, which outperform several compounds in prior studies, but also for the number of hydrogen bonds formed. Compound 7a was capable of forming 10 strong hydrogen bonds as well as interact to the protein receptor with a binding energy of -7.79 kcal/mol. Therefore, these compounds should be highlighted in further experimental studies in the context of treating SARS-CoV-2 infection and its effects.
Antimicrobial and anti-inflammatory activity of Terminalia arjuna
Authors: Mahendra Jaideep
Published: March 2023

Terminalia arjuna is one of the important herbal plants with cardioprotective, antihyperlipidemic activity and many more applications. In the present investigation, In order to find out the protective role, we prepared aqueous and ethanolic extract of Terminalia arjuna. The objective of this study was to comparatively evaluate the antimicrobial and anti-inflammatory activity of aqueous and ethanolic extract of Terminalia arjuna and to compare between the two. Antimicrobial activity of the plant extract was assessed by using agar well diffusion method against oral pathogens. The anti-inflammatory activity of prepared Terminalia arjuna plant extract was analyzed using egg albumin denaturation assay. The results of this study, showed that both aqueous and ethanolic extract had very good antimicrobial activity against Staphylococcus aureus, Pseudomonas species followed by Escherichia coli. However, the aqueous extract showed higher anti-inflammatory activity when compared with ethanolic extract. So it can be concluded that aqueous extract of Terminalia arjuna could be used as a local drug delivery agent in the treatment of chronic periodontitis.
Microsatellite diversity in four cultivated species of Actinidiaceae and Rutaceae
Authors: Kaur Simerpreet
Published: March 2023

Microsatellites or Simple Sequence Repeats (SSRs) are short iterations of 1-6 bp in the genomes of almost all living organisms. Our study aimed to explore the microsatellite diversity in four cultivated species, namely Actinidia chinensis, Actinidia eriantha, Citrus maxima, and Citrus sinensis of the Actinidiaceae and Rutaceae families. We present a comprehensive analysis of microsatellite abundance, distribution, and motif composition in the genomes of these species. The association of microsatellite abundance with genomic features such as genome size, GC content, number of microsatellites, relative abundance, and relative density was also examined. The results revealed significant variations in the frequency and distribution of microsatellites across the genomes of these four species. Notably, a positive correlation was observed between genome size and microsatellite number as well as with GC content, indicating that larger genomes provide more opportunities for the accumulation of microsatellites. Furthermore, a negative correlation of genome size with relative microsatellite abundance and relative density was observed. These findings provide new insights into the microsatellite landscape of Actinidiaceae and Rutaceae, which could be explored for the development of microsatellite markers for diverse applications in the characterization of genetic diversity, molecular plant breeding, and phylogenetic analysis.
« J’apran mon sexe à se pouvoir vanger » : les leçons de Médée (La Péruse, s.d.)
Authors: Hugot Nina
Published: March 2023

À la fin de Médée, La Péruse fait tenir à l’héroïne des propos particulièrement inquiétants, puisqu’elle indique que le spectacle qui vient d’avoir lieu pourra « [apprendre] à [son] sexe à se pouvoir vanger » (La Péruse, 1990 [s.d.] : 42). Comment comprendre ces vers? On peut conclure à l’ironie du dramaturge, puisque Médée, infanticide et régicide, ne saurait être sérieusement érigée en exemple. Néanmoins, si on se met à l’écoute de la Colchidienne, on peut observer d’autres résultats : La Péruse semble insister sur les pouvoirs de la parole féminine, si bien que Médée pourrait apprendre aux femmes non le meurtre, mais la puissance des mots.
Legal Framework for the Regulation of Sanctions Measures in the European Union
Authors: Topornin Nikolai Borisovich
Published: March 2023

The subject of this article is the legal basis of the mechanism for the adoption of sanctions (restrictive measures) within the European Union. The author traced the evolution of the application of sanctions since the creation of the European Economic Community (1957) to the present day, analyzed the relevant sections of the most important constituent acts of the EU and considered the features of the EU sanctions mechanism at the present stage. In recent decades, the practice of applying political and economic sanctions has significantly expanded in the system of international relations. At the same time, if earlier the initiator of international restrictive measures was usually the UN Security Council, now the world is dominated by unilateral national sanctions adopted on the basis of domestic political and legal norms. Somewhat apart in this process are the countries of the European Union, which are guided by collective sanctions measures approved within the EU. The purpose of this article is to study the specifics of the EU sanctions policy, to determine the legal nature of collective sanctions, as well as their compliance with the current principles and standards of modern international law.   In the course of the evolution of the European Union as a subject of international legal relations, a special place was given to the formation of the common Foreign and Security Policy of the EU. The author comes to the conclusion that the gradual transformation of an economic association into a political union has led to the need for a unified coordinated policy in the international arena. According to the author, at the present time, the sanctions measures of the European Union have become an integral part of the PRSP, strengthening its role and importance as an important chain in the system of international relations. At the same time, the EU, not having its own armed forces, increasingly considers collective sanctions as an instrument of its political and economic influence in the world. The novelty of this study lies in the consideration of the EU sanctions mechanism from the point of view of the formation of a single common foreign policy of this supranational union.
The role of personal characteristics of adolescents in the perception of outdoor advertising
Authors: Goryacheva Marina Andreevna
Published: March 2023

The article presents the results of an empirical study of the perception of outdoor advertising by a teenage audience. In the course of a study conducted among Novosibirsk schoolchildren of the middle and older age groups, the influence of such personal characteristics as the level of aggressiveness and value orientations on the image of ideal advertising, as well as the perception of outdoor advertising of a neutral, aggressive and cynical type was studied. The subject of the study is the personal characteristics of adolescents in the perception of advertising. The object of the study is the perception of advertising by teenagers. This article presents the results of an empirical study, the purpose of which was to identify the personal characteristics of adolescents that affect the perception of outdoor advertising.   The scientific novelty of the study is to study the attitude to unethical advertising of teenage schoolchildren of different age categories. Since the perception of outdoor advertising by teenagers, taking into account the key personal and psychological traits of this age group, remain poorly researched. In the course of the study, it was revealed that only neutral advertising corresponds to the profile of ideal advertising, whereas aggressive and cynical advertising does not have the appropriate features regardless of age and personality characteristics. The study revealed differences in the perception of advertising materials by adolescents of different ages, levels of aggression and the severity of life orientations. However, there were no socio-psychological grounds for the use of aggressive and cynical elements in advertising communication with a teenage audience.
Novel Ion-imprinted Polymer as a Tool for Selective Determination of SbIII in Natural Waters
Authors: Yordanova Tanya , Dakova Ivanka , Karadjova Irina
Published: March 2023

A novel SbIII-imprinted polymer was synthesized via radical copolymerization of methacrylic acid and trimethylolpropane trimethacrylate in the presence of 2-mercapto-N-(2-naphthyl)acetamide as a chelating ligand forming the functionality of specific binding sites. The extent of ligand incorporation in the active centres was evaluated by elemental analysis and found to be 73.6%. The IIP was utilized as a sorbent material for selective solid-phase extraction of SbIII in drinking waters after optimization of sorption and desorption processes in a batch mode. Excellent separation of SbIII and SbV was accomplished at pH 8 followed by elution of SbIII with 0.5 M thiocarbamide. Analytical procedure for non-chromatographic speciation and determination of SbIII was developed demonstrating very good precision (RSD 7–11%) and recoveries between 97–105%. This procedure enabled up to 25-fold reconcentration and completely met the requirements of EU legislation for the quality of water intended for human consumption.
A New Combined Non-invasive Method for Assessment of Liver Steatosis and Fibrosis in NAFLD Patients – Pilot Study
Authors: Komitova Teodora , Mitova Rumiana , Pavlov Kaloyan , Gerdzhikova Klimentina , Terziev Ivan , Vladimirov Borislav , Genov Jordan
Published: March 2023

The aim of this study was to investigate the clinical efficacy (sensitivity,  specificity) of ultrasound-based imaging methods for the assessment of fibrosis and steatosis in patients with non-àlcoholic fatty liver disease (NAFLD). Sixty-six patients with NAFLD and 43 healthy volunteers (control group) were tested. Liver biopsy was used as a reference method for the evaluation of NAFLD. Liver stiffness measurement (LSM) with transient elastography (TE) and two-dimensional shear wave elastography (2D-SWE) was used to assess fibrosis. Steatosis was assessed by Controlled Attenuation Parameter (CAP) and EchoLevels (ELs). Using the ELs, two hepato-renal indices were calculated – the hepato-renal index difference (HRIdiff) and hepato-renal index ratio (HRIratio). Additionally, one serum biomarker was calculated – APRI. Cut-offs of cirrhosis (F4) were defined as follows: ≥ 9.64 kPa and ≥ 9.85 kPa for 2D-SWE and TE. Only 2D-SWE had a correlation for significant fibrosis – the cut-off was ≥ 6.50 kPa and for lack of significant fibrosis (F < 2) less than 5.26 kPa. Steatosis was diagnosed with a cut-off of 240.50 dB/m for CAP, and HRIdiff ≥ 0.39, and HRIratio ≤ 0.99 for ELs. Both types of SWE and the two methods for evaluation of ultrasound (US) attenuation have good correlation with fibrosis and steatosis in NAFLD.
Histone deacetylase 1 maintains lineage integrity through histone acetylome refinement during early embryogenesis
Authors: Zhou Jeff Jiajing , Cho Jin Sun , Han Han , Blitz Ira L , Wang Wenqi , Cho Ken WY
Published: March 2023

Histone acetylation is a pivotal epigenetic modification that controls chromatin structure and regulates gene expression. It plays an essential role in modulating zygotic transcription and cell lineage specification of developing embryos. While the outcomes of many inductive signals have been described to require enzymatic activities of histone acetyltransferases and deacetylases (HDACs), the mechanisms by which HDACs confine the utilization of the zygotic genome remain to be elucidated. Here, we show that histone deacetylase 1 (Hdac1) progressively binds to the zygotic genome from mid-blastula and onward. The recruitment of Hdac1 to the genome at blastula is instructed maternally. Cis-regulatory modules (CRMs) bound by Hdac1 possess epigenetic signatures underlying distinct functions. We highlight a dual function model of Hdac1 where Hdac1 not only represses gene expression by sustaining a histone hypoacetylation state on inactive chromatin, but also maintains gene expression through participating in dynamic histone acetylation–deacetylation cycles on active chromatin. As a result, Hdac1 maintains differential histone acetylation states of bound CRMs between different germ layers and reinforces the transcriptional program underlying cell lineage identities, both in time and space. Taken together, our study reveals a comprehensive role for Hdac1 during early vertebrate embryogenesis.
The role of expectations, control and reward in the development of pain persistence based on a unified model
Authors: Büchel Christian
Published: March 2023

Chronic, or persistent pain affects more than 10% of adults in the general population. This makes it one of the major physical and mental health care problems. Although pain is an important acute warning signal that allows the organism to take action before tissue damage occurs, it can become persistent and its role as a warning signal thereby inadequate. Although per definition, pain can only be labeled as persistent after 3 months, the trajectory from acute to persistent pain is likely to be determined very early and might even start at the time of injury. The biopsychosocial model has revolutionized our understanding of chronic pain and paved the way for psychological treatments for persistent pain, which routinely outperform other forms of treatment. This suggests that psychological processes could also be important in shaping the very early trajectory from acute to persistent pain and that targeting these processes could prevent the development of persistent pain. In this review, we develop an integrative model and suggest novel interventions during early pain trajectories, based on predictions from this model.
Dorothea Tanning: Erotic and Dark Aesthetics
Authors: Hamimed Nadia
Published: March 2023

Inspired by the greatly stimulating psycho-dramas of gothic and erotic fiction and the revolutionary potential of Surrealism, Dorothea Tanning renovates images which aim to go into the nature of feminine (and infancy) sensual and corporal experience, falling down the frontier between the real world and imagination pro a smooth inventive world wherein all odds can imaginably exist. The most famous work of Tanning art is perhaps the one from the 1940s where the artist utilizes a specific vivid approach to represent eroticism. Nevertheless, in deviating from this method to a further theoretical way, the woman artist scatters her wish to depict the gothic just as she was illustrating a gothic tale, to remind the gothic appreciation of difference and disintegration via pensiveness. An erotic charge throbs throughout Tanning’s work; youthful girls’ clothes seem ragged and hair tackled a lavish life of its own as the boundary between inexperience and knowledge becomes blurred. A power rises above the specifically erotic and turns out to be a more broad desire to live in any of its demonstrations.
Analysis on the Problems and Improvement Strategies in the Development of Fine Arts in China in the New Era
Authors: Zhang Naiqian , Xiao Mengfei , Liu Liuhan
Published: March 2023

This dissertation examines the problems and improvement strategies in the development of fine arts in my country in the new era. It starts with a brief introduction to the history and current situation of fine arts development in my country. Then, it analyzes the problems and challenges faced by the development of fine arts in my country, such as insufficient funding, lack of innovation, and inadequate education and training. Finally, the dissertation proposes several improvement strategies, including increasing investment in fine arts, promoting innovation, and improving education and training for artists. Through this analysis, this dissertation aims to provide insights into the development of fine arts in my country and contribute to its future growth and prosperity.
Application of Apriori Algorithm in the Development of Hotel Management Information
Authors: Zhu Peifeng
Published: March 2023

The Apriori algorithm can effectively improve the efficiency and quality of the same time help accelerate the construction of smart hotels. Starting from understanding the application advantages of Apriori technology in the teaching of hotel management in higher vocational colleges, combining teaching cases to explore its specific application methods, and committed to giving It is hoped that the reports and related data generated by the evaluation system can be freely used by users, and users can operate and calculate the obtained data by themselves. higher vocational colleges. The thesis mainly discusses the information development and construction of the hotel management major courses in universities, taking the information development and construction of the marketing courses in this major as an example to carry out innovative applications of teaching reforms.
Design of English Guidance Information System Based on Multiple Reading and Writing Information Fusion Algorithm
Authors: Pengfei Zhou
Published: March 2023

Diversified literacy is a new requirement for students' literacy in today's information globalization and culturally diverse society. In college English teaching, based on the theory of multiple reading and writing, this paper designs an information-based system to guide the teaching of college English. According to the four steps of multiple reading and writing teaching method, students are trained in visual reading and writing, media reading and writing, digital reading and writing, and digital reading and writing. Multiple reading and writing skills such as critical reading and writing. Master multiple ways to build a multi-modal teaching model, and optimize the available multi-modal resources to the greatest extent, so as to stimulate the interest of non-English majors in English learning and cultivate their multiple reading and writing skills Ability and comprehensive application ability of English.
Development of Smart Sports in Colleges Based on Intelligent IoT Equipment with Digital Reform System
Authors: Honglin YOU , Zhuo BAO
Published: March 2023

The management of digital teaching system and the control of digital teaching quality are discussed in detail in the construction of software and hardware in the practice of digital reform of medical imaging and the key problems to be solved Based on the material conditions and human conditions of colleges and universities, a variety of practice paths will promote college sports to adapt to the changes of the times, and then promote the scientific fitness of the public. some advices. We work hard to address these issues and mobilize the forces of all parties. Take various measures. Actively strive to promote the scientific and humanized development of college physical education curriculum construction from the aspects of value orientation, functional system, status improvement, structural system, evaluation system, teaching qualifications, target system and teaching mode.
A Collection and Retrieval of Intelligent Teaching Data for Higher Vocational Finance and Economics Major Based on External Data Interface Optimization
Authors: Zou Jianjun
Published: March 2023

Firstly, it analyzes the requirements of the high-speed data transmission system, and then gives the design scheme of the bridge chip based on PCI EXPRESSS, including the logic design block diagram, interface description and bus timing. Higher vocational finance and economics majors mainly train high-skilled professionals in front-line management and service, and their professional characteristics of management and service put forward unique requirements for students' operational skills, professional ability and comprehensive quality. Aiming at the current teaching status of this course and some problems in the teaching process, under the guidance of the virtual learning situation teaching method, the corresponding solutions are put forward through the task-based teaching of the course knowledge points. Different from full-text crawling, distributed directional crawler requires fast crawling of deep and precise structured data from the Internet.
Conhecimento e senso de pertencimento territorial como indicadores de capital social em um município com economia de base mineral na Amazônia brasileira
Authors: De Loureiro João Paulo Borges , Dos Santos Marcos Antônio Souza , Lopes Maria Lúcia Bahia , Dos Santos Jorge Manuel Filipe , Demajorovic Jacques , Costa Nilson Luiz , Martins Cyntia Meireles
Published: March 2023

Neste trabalho avalia-se o grau de conhecimento da população de Parauapebas – maior município minerador do estado do Pará – sobre o recebimento da Compensação Financeira pela exploração de recursos minerais (CFEM) e sobre as compensações ambientais obrigatórias a serem desenvolvidas pelas mineradoras, além de captar o grau de pertencimento territorial da população da cidade. A proposta é confirmar a hipótese de que os habitantes da cidade, apesar do elevado grau de dependência econômica da mineração, ainda não conhecem aspectos legais inerentes a atividade e possuem baixo grau de pertencimento territorial. Para isso foram realizados dois levantamentos: um com 1.000 e outro com 1.024 habitantes da cidade para a geração de dois indicadores referentes ao conhecimento sobre mineração e pertencimento territorial. Foi comprovado que a população de Parauapebas possui, em sua maioria, um baixo grau de conhecimento sobre aspectos legais de recebimento de CFEM e compensações ambientais, assim como existe um baixo grau de engajamento da população nas atividades ligadas a gestão e cuidado do município, tais como audiências públicas e participação nas eleições. Isso evidencia um baixo grau de pertencimento com a cidade e esses dois problemas refletem na formação do capital social, visto que o panorama é de uma população de município minerador que não entende sobre mineração e que se manifesta pouco em termos de participação cívica na gestão da cidade.
Teletrabalho e atitudes frente à mudança em organizações públicas brasileiras: experiências e desafios
Authors: Oliveira Míriam Aparecida Mesquita , Pantoja Maria Júlia
Published: March 2023

As cooperativistas de crédito estão expostas ao risco de crédito como qualquer outra instituição financeira e este risco é definido como a possibilidade de o tomador não cumprir com suas obrigações junto a cooperativa, ou seja, de não honrar com o compromisso de pagar suas dívidas. Para mitigar este risco, as cooperativas realizam as provisões para crédito de liquidação duvidosa (PCLD), com a finalidade de cobrirem este tipo de risco que é inerente a suas operações. Temos que no início de 2020, uma forte crise de saúde pública, causada por uma pandemia seriamente contagiosa e com elevado grau de mortalidade, que ficou conhecida como pandemia da COVID-19 impactou toda a economia, com sérios desdobramentos sociais e econômicos. Estes eventos causaram uma crise financeira que se espalhou rapidamente, afetando a renda das pessoas, empresas e governo, sendo que este último, precisou socorrer os dois primeiros por meio de programas sociais e financeiros. Baseado neste contexto, este estudo, teve como objetivo, analisar se a PCLD aumentou após o início da crise econômica e de saúde nas 99 maiores cooperativas de crédito do Brasil, sendo que estas organizações foram selecionadas de acordo com os seus ativos totais. Foram analisadas as carteiras de crédito e a PCLD destas organizações no período de 2018 a 2021. Esta pesquisa é de cunho quantitativo e sua coleta de dados ocorreu por meio do banco de dados do BACEN. Os resultados, apontaram que durante a crise econômica, houve mudança significativa e acentuada na PCLD das instituições cooperativistas analisadas, porém esta mudança é percebida desde 2018, início das observações deste estudo.Palavras-chave: Cooperativas de Crédito. Provisão. Risco de Perdas. Covid-19.
The Theology of Salah and Psychosocial Some Wisdom for Social Life
Authors: ORAL Osman
Published: March 2023

Salât; sosyal hayatta destekleşme, yardımlaşma, danışma, duâ ve merhamet gibi psikolojik ve sosyolojik eylemleri kapsar. Kavram, Kur’an’da Allah’a, meleklere, insanlara ve kuşlara isnad edilir. Teolojik anlamda Allah’ın salâtı, kendisine
güvenen kulunu karanlıklardan aydınlığa çıkartması, yardımı ve rahmetidir. İnsan iradesini iyi ve güzele yönlendirdiğinde Allah’ın lütfu, meleklerin yardımıyla cehâlet ve inkâr karanlıklarından ilim ve iman ışığına çıkar, salih
amel ve güzel ahlâk davranışlarına yönelir. Her varlığın salâtı, yaratılış hikmetine uygun eylemlerle evrenin işleyişine destektir. Kişinin insanî onur ve karakterle yaşayabilmesi için salât türü psikolojik ve sosyolojik eylemlere
ihtiyacı vardır. O, kalpleri arındırır, toplumsal bütünleşme ve uyumu sağlayarak ortak niyet, irade ve akıllar işlevsel hale gelir. Bu durum sosyal hayatta problemlerin çözümü ile başarılara, iyilik ve güzelliklere daha kolay ve
hızlı bir şekilde ulaşılmasını sağlar. Aynı zamanda kişinin hayatta insanî onur ve karakterle yaşayabilmesi için duâ, meşveret, destekleşme ve dayanışma gibi psikososyal tevhidî eylemlere ihtiyacını gösterir. İman, tevhid ve takvâ
gibi teolojik unsurlar salât ile yaşayabilir. Allah kendisine güvenen, fert ve toplum hayatında huzurlu ve mutlu yaşamak isteyenlere salâtı sabırla ve içten yapmalarını öğütler. Kur’an’da yüzden fazla âyette geçen salât ilahî rızaya
uygun doğru bir şekilde anlaşıldığında fert ve toplum hayatına güzel ahlâk ve salih amel olarak yansıyabilir. Sadece “Namaz” anlamı kavramın kapsamını daraltacağından birçok anlama problemine sebep olabilir. Geniş anlam alanına
sahip psikososyal bir kavram olan salâtın hikmetleri işlevsiz kaldığı takdirde gâfil birey ve toplumlar sefâlet, atâlet ve cehâlete düşebilir, felsefî ve mistik eğilimlere yönelebilirler. Farklılıklarla birlikte insanca yaşam,
barış, vahdet, eşitlik, adâlet, hoşgörü ve kardeşlik gibi eylemlerle mümkün olduğundan arkaplanında tevhid olan herbir salât eylemi Kur’an’a göre ibadettir, tüm varlıkların yaratılış hikmetidir. Hayatın canlılığı ve değerlendirilmesi,
akıl, duyu, duygu ve iradeyi içeren destekleşme, yardımlaşma, danışma, üretim, eğitim, öğretim, duâ ve merhamet gibi salât eylemleriyle olur. Sosyal hayat için salâtın psikososyal hikmetlerini canlı tutmak “Salâtın ikâmesi ve muhafazası”
olarak adlandırılabilir.
Use Of Reading Texts Based on Reading Strategies in the Process of Distance Education: Child Development Associate Sample
Authors: OKUTKAN Cansev
Published: March 2023

Küresel covid 19 salgını ile eğitimde önemli bir yer edinmeye başlayan dijital öğrenme ortamlarının, pandemi sonrasında da eğitimde kalıcı olacağı tahmin edilmektedir. Uzaktan eğitime uyum sağlamaya çalışan eğitimciler ve öğrenciler
için dijital öğrenme ortamları ile ilgili araştırmalar önem kazanmaktadır. Bireyselleştirilmiş öğretime dayalı uzaktan öğrenme ortamlarında öğrencilerin okuma becerilerinin gelişmiş olması başarıyı artıracaktır. Öğrencilerin okuduklarını
daha iyi anlamlandırabilmeleri için, öğrenme ortamlarında okuma stratejileri ile ilgili çalışmalara ağırlık vermek gerektiği düşünülmektedir. Bu ihtiyaçtan yola çıkılarak bu çalışmada 2021-2022 Güz yarıyılında Çocuk Gelişimi önlisans
programında yer alan “Çocukla İletişim” dersini uzaktan eğitim yoluyla daha verimli kılacak uygulamaları değerlendirmek amaçlanmıştır. Araştırmada nitel araştırma yöntemlerinden eylem araştırması tercih edilmiştir. Araştırmacının
uygulayıcı olarak yer aldığı bu araştırmada dersin öğrenme-öğretme sürecinde “okuma metinlerinin ve okuma stratejilerinin temele alındığı bir yaklaşım” benimsenmiş ve bu yaklaşıma uygun uygulamaların süreç boyunca yansımaları araştırılmıştır.
Araştırma için 14 haftalık bir eylem planı hazırlanmıştır. Araştırmaya amaçlı örnekleme yöntemi kullanılarak farklı başarı seviyesi ve sınıflardan kırk öğrenci dahil edilmiştir. Öğrencilerden toplanan veriler; açık uçlu anketler,
öğrenci ödevleri ve görüşmeler ile elde edilmiştir. Süreç boyunca öğrencilerden alınan geribildirimler doğrultusunda gerekli düzenlemeler yapılmıştır. Araştırma bulgularına göre, Çocukla İletişim dersinde okuma stratejilerinin
kullanımına dayalı okuma metinlerinin temel alındığı bir uzaktan öğrenme sürecinin, öğrenci motivasyonuna ve dersin verimliliğine katkı sağladığı sonucuna varılmıştır. Bu sonuçlardan hareketle konuyla ilgili farklı araştırmalar
yapılması ve farklı derslerde de benzer uygulamalar yapılması önerilmektedir.
Cognitive Basis of Digital Language Learning Meterials
Authors: KAYGISIZ Çağrı
Published: March 2023

Digital transformation, which emerged as a natural result of technological development, has caused radical changes in learning–teaching paradigms, as in other areas of life. While this situation allows for the review of teaching methods
and techniques and improvement in the quality of education, it also necessitates the integration of all educational practices and procedures to the new system. Digitalization in education is most evident in terms of material development.
Therefore, it is necessary to set the standards for and take a series of decisions on adapting teaching materials, which interact with elements in the learning–teaching environment, to digital teaching environments. The most important
factor in the effectiveness of instructional designs for meaningful learning is knowledge about the functioning of the cognitive system. Therefore, because of the critical role it plays in perception and learning processes, information
about the functioning of the cognitive system has a vital role in the design and development of language teaching materials; thus, it is considered the main subject of material development studies. Accordingly, the study aims to
theoretically discuss the cognitive principles that should be taken into account in the design and development processes of digital teaching materials based on the research on the operation principles of the cognitive system.
Bibliometric Analysis of Educational Research Articles Published in the Field of Environmental Literacy
Authors: BOZDOĞAN Kerem , ŞAHİNPINAR Dilek , KARATEKİN Emrullah
Published: March 2023

Bu çalışmada bibliyometrik göstergeler açısından çevre okuryazarlığına ilişkin eğitim araştırmaları makaleleri incelenmiştir. Araştırma nitel araştırma modellerinden olan betimsel tarama modelinde olup verilerin analizinde bibliyometrik
analiz tekniği kullanılmıştır. Veriler Clarivate Analytics tarafından üretilen Web of Science veri tabanından alınmıştır ve tarama aralığı 1975-18 Ocak 2022 olarak belirlenmiştir. Tarama sonucunda 73.741.061 çalışmadan 419 tanesinin
Çevre Okuryazarlığı ile ilgili olduğu belirlenmiş, bunların 138 tanesinin (%32,93) eğitim/eğitim araştırmaları kategorisinde yer alan makaleler olduğu ortaya çıkmıştır. Yapılan analizlerde çevre okuryazarlığına ilişkin olarak en
çok yapılan çalışmanın makale olduğu belirlenmiştir. Söz konusu makalelerde toplam 426 farklı anahtar kelime kullanıldığı görülmüştür. Yayınlanan makalelerin 72 tanesinin son beş yıla ait olduğu tespit edilmiştir. Bu oran çevre
okuryazarlığı ile ilgili eğitim araştırmalarının son yıllarda artma eğiliminde olduğunu göstermektedir. Yapılan analizlerde literatüre katkıda bulunan 339 farklı yazar olduğu gözlenmiştir. Bu kapsamda en etkin derginin “Environmental
Education Research” olduğu tespit edilmiştir. Elde edilen bir başka bulguya göre eğitim/eğitim araştırmaları kategorisinde yayınlanan makalelerde 37 farklı yayıncı kuruluşun adı yer almaktadır. Bu kapsamda en aktif kuruluşun Taylor
& Francis olduğu belirlenmiştir. 33 farklı ülkeden araştırmacıların alana katkı sağlayan makaleler yayınladıkları belirlenmiş ve bu kapsamda en aktif ülkenin Amerika Birleşik Devletleri olduğu ortaya çıkmıştır. Bu ülkeyi sırasıyla
İsrail ve Türkiye’nin izlediği görülmüştür. 20 makale ile Türkiye 3. sırada yer almıştır. Bu durum alanla ilgili önemli çalışmalara zaman ayrıldığını göstermektedir.
Cindy Sherman: Grotesque and Fantasmagoria
Authors: TURAN Seda Liman
Published: March 2023

Postmodernist sanatçı Cindy Sherman, filmlerden ve feminen dergilerden ilham aldığı kurgusal portreleri ile eleştirel fotoğrafçılığı gündeme getirmiştir. Sherman’ın eserleri fotoğraf ve performans sanatını sentezleyip postmodernizme
yeni bir bakış açısı kazandırmıştır. Sherman, kadın arketiplerini ve toplumsal cinsiyet konularını marjinal bir şekilde ifade etmeyi başarmıştır. Gündeme geldiğinden beri feminist bir sanatçı olarak tanımlanan Sherman’ın eserlerinde
bedene yüklenen misyon izleyiciyi daha derinden etkileyebilmek ve kimliklerimizi daha eleştirel bir dille sorgulamamızı sağlamak amacıyla abartılı bir biçimde ifade edilmiştir. Araştırmanın amacı; feminist sanat hareketinin en
önemli temsilcilerinden Cindy Sherman’ın eserlerini grotesk ve fantazmagori kavramları bağlamında incelemektir. Nitel araştırma yöntemlerinden doküman analizi kullanılan araştırmada konu ile ilgili veriler, psikanalitik eleştiri
yöntemi ile analiz edilmiştir. Araştırma sonucunda; Sherman’ın eserlerinde idealize edilmiş güzelliğe tepki olarak kadın figürlerini, toplumsal cinsiyet rol kısıtlamalarını, kadınlarla ilişkilendirilmiş klişe rolleri, istismarı;
iğrenç, çirkin, şaşırtıcı, tedirgin edici, ürkütücü misyonları grotesk bir tavırla fantazmagorik görüntülerle ifade ettiği sonucuna ulaşılmıştır. Postmodernist sanatçı Sherman eserlerinde, özelikle fotoğraf ve performans sanatını
melez bir bakış açısıyla paradoksal olarak izleyiciye sunarak; kadınların sahte bronzluk, makyaj, kozmetik cerrahi ve moda aracılığıyla yaptıkları tuhaf seçimleri sorgulamaktadır. Eserlerindeki grotesk tavırlar, canlandırdığı rollerle
empati kurarak hayranlık, parodi, suç ortaklığı ve alay arasında oldukça ince bir çizgide dengede kalmaktadır. İzleyicinin kurguya dâhil olduğu, ancak nasıl okunacağı konusunda yönlendirilmediği grotesk görüntüler; bazen büyüleyici,
bazen şaşırtıcı, bazen savunmasız, bazen tehditkâr, bazen iğrendirici, bazen korkutucu ama her şeyden önemlisi asla Sherman’ın kendisi olmayan; oldukça yaratıcı ve eleştirel bir bakış açısının fantazmagorileridir.
Views of Turkish Teachers on Textbooks in the Context of Refugee Students' Education
Authors: DURHAT Gözde , ÖKTEN Celile Eren
Published: March 2023

Suriye Arap Cumhuriyeti’nde meydana gelen iç savaş neticesinde milyonlarca Suriye vatandaşı sınır komşusu olan Türkiye’ye göç etmiştir. Göç edenlerden %30’una yakınının eğitim çağındaki çocuklardan oluşması Türkçenin ikinci dil olarak
öğretimi sürecine de yeni bir soluk getirmiştir. Kapsayıcı eğitim bağlamında devlet okullarında karma sınıflarda öğrenim gören Suriyeli öğrenciler yerli akranlarıyla birlikte farklı bir programa tabi olmadan Türkçeyi ikinci dil
olarak öğrenmeye çalışmaktadır. Araştırma kapsamında karma sınıflarda öğrenim gören Suriyeli öğrenciler için 6. sınıf Türkçe ders kitaplarının dil yeterliklerini karşılama düzeyi üzerine Türkçe öğretmenlerinin görüşleri alınmıştır.
“Kapsayıcı Eğitim Bağlamında Türkçenin İkinci Dil Olarak Öğretilmesine Yönelik Öğretmen Kapasitesinin Güçlendirilmesi Eğitici Eğitimi Hizmet İçi Eğitim Kursu”na katılan, Türkiye’nin farklı coğrafi bölgelerinde öğretmenlik yapan
ve sınıflarında mülteci öğrenci bulunan 18 Türkçe öğretmeniyle yarı yapılandırılmış görüşme gerçekleştirilmiştir. Nitel araştırma desenlerinden olgubilim kapsamında yürütülen araştırmada veriler, ses kaydı yoluyla toplanmış; tümevarımsal
içerik analizine göre çözümlenmiştir. Araştırmadan hareketle Türkçe öğretmenlerinin ders kitabını mülteci öğrencilerin dil yeterliklerine göre uyarladıkları, bazı öğretmenlerin yalnızca çalışma kâğıdı ve teknoloji destekli uygulamalarla
dersi işledikleri, mülteci öğrencilerin Türkçe dersine uyum sağlayabilmesi için hâlihazırda uygulamada olan uyum sınıflarının temel düzeyde okuma yazma eğitimi alınabilmesi için çözüm olarak görüldüğü, yerli öğrencilerle aynı sınıf
ortamından koparılmadan eğitim almaları gerektiği, 6. sınıf Türkçe ders kitabının mülteci öğrencilerin dil yeterliklerinin üzerinde olduğu ve derse katılımı teşvik etmediği, yerli öğrenci tutumlarının mülteci öğrencilerin derse
katılımını ciddi oranda etkilediği, en çok yazma becerisinde sorunlarla karşılaştıkları sonucuna ulaşılmıştır.
Could not Muslim Philosophers Prove that God is not Corporeal? al-Ghazālī’s Claims in Tahāfut, Muḥyī al-Dīn al-Qarabāghī’s Approach
Authors: BAGA Mehmet Sami
Published: March 2023

İslam felsefe-bilim tarihinin önemli metinlerinden biri olan Gazzâlî’nin Tehâfütü'l-Felâsife adlı eserinde Meşşâî filozofların görüşleri yirmi başlık altında sıkı bir eleştiriden geçirilmiştir. Bu eleştirilerden bir kısmı, felâsifenin
görüşlerinin dini açıdan problem teşkil etmesi ile ilgilidir. Ancak bazı başlıklardaki eleştiriler ise farklı bir sebebe dayanmaktadır: İddia edilen görüşü yeterince delillendirememek. Bu başlıklardan biri de Tanrının cisim olup
olmadığıdır. Burada Gazzâlî iddialı bir açıklama yaparak filozofların Tanrının cisim olmadığını dahi ispatlamaktan aciz olduklarını öne sürmektedir. Onun, şeriate aykırı olmadığı sonraki düşünürler tarafından da açıkça ifade edilen
“Tanrı cisim değildir” şeklindeki bir görüşü neden eleştiri konusu yaptığı ilgi çekici bir husustur. Öyle görünüyor ki Gazzâlî, filozofların kesinlik iddialarının herkesçe anlaşılır bir konuda dahi sorgulanmaya açık olduğunu ortaya
koymayı amaçlamaktadır. Böylece farklı eserlerinde çeşitli vesilelerle dikkat çektiği filozofların kesinlik iddiasının aslında sağlam temellere dayanmadığını göstermek istemiş olmalıdır. Ancak Tehâfüt geleneği içerisindeki pek
çok düşünürün bu yaklaşım biçimini ciddi manada eleştirdiği görülür. Bu düşünürlerden biri de Muhyiddin Karabâğî’dir. Karabâğî, filozofların şeriata aykırı olmayan bu türden görüşlerinin eleştiri konusu yapılmasını çok açık ifadelerle
eleştirmekte ve bunu gereksiz bulmaktadır. Bu çalışmada Gazzâlî'nin bu konudaki iddialarının dayanakları ortaya konulacak, sonraki Tehâfüt müelliflerinin bu iddiaya nasıl yaklaştıkları incelenecek, ardından Karabâğî’nin bu konudaki
yaklaşımı değerlendirilecektir. Böylece Tahâfüt’ün nisbeten az ele alınan bir başlığının cisim teorisi açısından irdelenmeye ve Gazzâlî’nin bu eseri kaleme almasındaki nihai hedefleri tespitine gayret edilecektir.
Panoptic City and the Pragmatism of Surveillance: A Qualitative Research on Gated Communities
Authors: KURTBAŞ İhsan , AKÇAKAYA Onur , SARAÇBAŞI Yasemin HAYTA
Published: March 2023

This article was written to look into the pros and cons, as well as the different effects, of surveillance in cities in a deep and multifaceted way. In this context, in-depth interviews were conducted using a semi-structured interview
form with 14 people, consisting of site managers and residents of a high-security site in Erzurum. The aim of the study is to reveal the multiplier effects of surveillance (positively and negatively) by examining the purpose of
the existence of high-security sites where the urban elites are clustered, how these sites fill the gap in community life, why people cluster in these places, and what their residents' expectations are from secure sites. The intersection
of surveillance and urban security literature is explored and focused on the urban panopticon phenomenology in this context. The urban panopticon is a diagram of mechanisms that includes the psycho-spatial, psycho-social, and psycho-political
effects of surveillance sets consisting of various control and control mechanisms in cities. This concept will enable the enrichment of two powerful fields, the city and surveillance, by producing its own literature, as well as
the crystallization of the meaning and context arising from the evaluation of surveillance as a whole. In fact, when we look at the literature on surveillance within social theory, we see two common but opposing views: surveillance
is either referred to as a tool of power or as one of the modern demographic participation mechanisms. Based on the field research data, this study put forward the concept of "Pragmatism of Surveillance" as a third way to reconcile
these opposing approaches and strengthened it with various arguments. The pragmatism of surveillance refers to the fact that people living in cities in modern times regard surveillance as an indispensable element of their lives,
putting "security" at the center. In this context, the argument that surveillance restricts freedom and violates private space is an issue that should be approached cautiously in terms of the urban panopticon. Similarly, residents
of the high-security complex stated that security is the most important factor in choosing these locations, that surveillance regulates social relations within the complex and contributes to the revival of civilized society. Another
striking finding here is the requests and demands of the residents of the site to have camera surveillance throughout the site, including the elevators, so as not to leave any gaps. Although the secure sites house the elites of
the cities, almost all of the interviewees stated that the places where there is no camera can give the impression of "dereliction, anonymity, and desolation." In the study, this situation was identified with the "broken glass
theory" and tried to be explained through this theory.
Effectiveness of Procalcitonin as a Diagnostic Marker vs Other Inflammatory Markers in Infected Diabetic Foot Ulcers: A Case-control Study
Authors: Dhruva HM , Gopal Sridhar , Narayanswamy T
Published: March 2023

Introduction: Procalcitonin (PCT), is an amino acid protein precursor of calcitonin hormone, which is released by thyroid parafollicular cells or other body cells. Procalcitonin alone or along with other biomarkers of infection such as erythrocyte sedimentation rate( ESR) and C-reactive protein (CRP) can be used as a marker for diagnosing diabetic foot infection. Aim: To determine the effectiveness of PCT, as a marker for infected Diabetic Foot Ulcer (DFU) in comparison with other inflammatory markers such as CRP, White Blood Cell count (WBC), and ESR. Materials and Methods: This case-control study was conducted at Department of General Surgery, Kempegowda Institute of Medical Sciences, Bangalore, Karnataka, India from January 2018 to December 2018. Total 90 patients were classified into three groups with 30 patients in each group: group I had patients with diabetes but without foot ulcers while group II patients having Non infected DFU (NIDFU) and group III patients having Infected Diabetic Foot Ulcer (IDFU) served as cases. The parameters assessed were demographic data, blood pressure, Body Mass Index (BMI), diabetic complications like nephropathy, retinopathy and myocardial ischaemia and inflammatory markers. Results: The mean age in group I was 46.9±5.11 years., group II was 47.8±6.65 years and in group III was 49.3±7.83 years. The gender distribution were group I (male 19, female 11), group II (male 13, female 17), group III (male 14, female 16). Serum PCT levels were 1.43±0.52 ng/mL in group III versus 0.18±0.17 ng/mL and 0.08±0.05 ng/mL in group II and group I respectively, with a significant p-value of 0.001. The PCT levels was significantly higher in patients with IDFU compared with the traditional markers like CRP (53.8±16.4 mg/dL, p-value=0.001), ESR (49.0±9.24 mm/hr, p-value=0.034) and WBC (10.2±3.18×109 / dL, p-value=0.014). Conclusion: It was concluded that PCT, as a vital biochemical parameter, has an significant role to diagnose the infection in DFU as compared to CRP, WBC count and ESR.
Phenytoin versus Normal Saline Dressings in the Healing of Chronic Diabetic Foot Ulcers: A Longitudinal Study
Authors: Babu Bogarapu Chaithanya , Ramu Ulala Kodanda , Mahalakshmi Budda Kanaka , Rao Konkena Janardhana , Sai Jami Yaswanth , Siri Gopisetty , Aishwarya Munagala Poornima , Manohar Devi Murali
Published: March 2023

Introduction: Chronic wounds, especially the non healing type, are among the foremost common conditions encountered by a surgeon. Currently, steady research is being pursued on the creation of fancy and indulgent topical growth factors for wound healing. One such agent is phenytoin which has a stimulatory effect on connective tissue. Several studies were conducted worldwide to study the effect of phenytoin on chronic ulcers. However, such studies are lacking in our geographical area. Aim: To compare the efficacy of topical phenytoin dressings with conventional saline dressings in the healing of chronic Diabetic Foot Ulcers (DFUs), in terms of the surface area of ulcer, granulation tissue formation as a percentage of the surface area of ulcer, duration of hospital stay, and side effects. Materials and Methods: This was a longitudinal study that included 100 patients with chronic DFUs admitted to a tertiary care hospital, in North Andhra Pradesh for a period of 1 year. The study population was divided into two groups based on the patient’s willingness for undergoing topical phenytoin therapy. Patients willing to undergo the topical phenytoin dressing therapy formed the study group (n=50) and those who were not willing were subjected to traditional saline dressings, which formed the control group (n=50). The variables of the surface area of the ulcer, granulation tissue formation as a percentage of the surface area of the ulcer, duration of hospital stay, and side effects of topical phenytoin dressings were compared using Paired, and Unpaired Student’s t-test, and the p-value of <0.05 was considered significant. Results: The mean age in the study group was 53.94 years and in the control group was 55.92 years. The male:female ratio in the study group was 5:1 and in the control group was 3:1. The mean ulcer surface area in the control group was 37.6 cm2 and in the study group was 40.4 cm2 (p-value=0.012). The mean area of granulation tissue formation in the control group was 36.07 cm2±5.7, and in the study group was 39.63 cm2±2.6 of the total ulcer surface area (p-value=0.001). The granulation tissue formation in the control group was 95.93% of the total ulcer surface area, and in the study group was 98.09% of the total ulcer surface area (p-value=0.001). The mean hospital stay in the control group was 31.3±4.2 days and in the study group was 27.8±2.4 days (p-value=0.001). Conclusion: Phenytoin is better alternative dressing agent with lesser side effects for diabetic foot ulcer care.