bluuebunny/crossref_metadata_2025 huggingface dataset:
Stress and Stress Coping Strategies Among Iraqi Foreign Language Teachers: A Mixed-Method Inquiry
Authors: Salah Mahdi Yousif Al-Maliki
Published: September 2024

In today's society, the modern way of life is often associated with a significant level of stress. Education field is no exception. The occupational stress encountered by EFL teachers can be defined as the adverse emotions they experience as a result of different elements of their job. The stress experienced by individuals is often a response to perceived threats stemming from the pressures and expectations placed upon them.  Consequently, the objective of the present investigation was to examine the stressors encountered by EFL instructors and the techniques they employ to manage it. The study involved 115 EFL teachers.   Data was gathered through the utilization of two questionnaires, specifically the Teachers' Stressors Questionnaires and the teachers' coping strategy questionnaire, as well as a semi-structured interview.  In addition, descriptive statistics were used to analyze the data. The findings show that the majority of teachers have experienced stress and that all of the suggested factors are significantly associated with the issue.   The primary finding indicates that stress negatively affects the professional performance of English as a Foreign Language (EFL) educators.   Overall, these results hold important implications for the progression of future academic studies and pedagogical methodologies.
Transformasi Media Sosial dalam Praktik Public Relations
Authors: Ahmad Zakki Abdullah  , Mia Nurmiarani  , Priyono Sadjijo
Published: September 2024

The development of social media has transformed the landscape of communication and Public Relations (PR) practices. In this digital era, PR practitioners are required to understand and utilize social media effectively in efforts to build strong relationships with the public. This study aims to investigate the role of social media in PR practices, focusing on identifying current trends, changes, and challenges faced by PR practitioners in adopting social media. The method of literature review is used to gather and analyze information from various sources. The research findings show that social media has become an integral component in PR strategies, enabling practitioners to interact directly with the public, respond to issues in real-time, and measure their communication impact more accurately. Recent trends highlight the importance of visual content, collaboration with influencers, and attention to sustainability and social responsibility issues. In conclusion, the transformation of social media has had a significant impact on PR practices, expanding reach, increasing engagement, and allowing for more accurate performance measurement.
Implementasi Pembelajaran IPS Terpadu Terhadap Pembentukan Karakter Sikap Peduli Lingkungan pada Siswa Kelas VIII MTs Unggulan Rohmatul Ummah Mojokerto
Authors: Zarotul Agustin
Published: September 2024

This research is motivated by the formation of environmentally caring character in students by teaching children to throw away rubbish, love plants or the environment and always maintain cleanliness wherever they are, especially in the school environment. Students are given activities about loving and caring for the environment, even if it's just cleaning the classroom.  This research uses a qualitative approach, the research location was carried out at MTs Unggulan Rohmatul Ummah Mojokerto, by optimizing the presence of researchers in extracting data based on sources, namely: (1) primary data sources (2) secondary data sources. The data collection techniques used were observation, interviews and documentation. The data analysis techniques used in this research are data collection, data reduction, data presentation and conclusion drawing, then checking the validity of the data findings using triangulation. The results of this thesis research are (1) The children have succeeded in changing their personalities in the way they interact, in keeping the environment clean, such as throwing rubbish in its place, always carrying out picket duties and inviting their friends to maintain cleanliness (2) Evaluation of the implementation of character education used by the school is carried out every Sunday or if possible every day by the homeroom teachers, teachers and also the principal, and also carried out every semester. In forming a socially caring character through Social Sciences subjects, it is able to change the character of students for the better.
Perubahan Tradisi Baralek pada Masyakarat Minangkabau di Kecamatan Medan Denai Kota Medan
Authors: Era Syafriani  , Neila Susanti  , Muhammad Jailani
Published: September 2024

This research aims to: describe changes in the baralek tradition in the Minangkabau community in Medan Denai District, Medan City, describe the factors causing the change in baralek in the Minangkabau Community in Medan Denai District, Medan City, describe the social actions of the community in implementing the baralek tradition in the Minangkabau community in Medan Denai District Medan City. This research uses a qualitative research method with a descriptive approach. The results obtained from this research are that the Minangkabau people in Medan Denai District continue to uphold Minangkabau cultural values, one of which is by continuing to carry out wedding procession procedures in accordance with Minangkabau customs. However, this was not fully carried out so that the baralek tradition underwent changes by adapting or modifying part of the procession in the baralek tradition. Factors causing changes in Minangkabau marriage procedures were; Economic Factors, Time Efficiency, Living Environment, Marriages of Different Tribes. The solidarity of the Minangkabau people remains strong. This can be seen from the contribution of the community working together in organizing a wedding party, such as working together in cooking and enlivening the event.
Efektivitas Model Pembelajaran Berbasis Proyek (Project-Based Learning) terhadap Keterlibatan Siswa di SMA Negeri 08 Kota Serang
Authors: Popi Dayurni  , Ade Fricticarani  , Kurniati Rahmadani  , Siswandy Siswandy
Published: September 2024

This research was motivated by the low level of student involvement in the subject. Student engagement is often a major challenge. Lack of student engagement can be caused by various factors, such as learning methods that are less interesting and irrelevant to their needs. The research aims to see the effectiveness of the project-based learning model on student involvement. The method used in this research is quantitative. The results of this research show that the Project Based Learning Model has proven to be effective for Student Engagement at SMA Negeri 08 Serang City by proving the results of this research using a paired sample t test, the result of tcount is -36.256 on df 17. The basis for decision making is if tcount > ttable then H0 is rejected and Ha accepted. The ttable value in df 17 is 2.110. Thus, 36.256 > 2.110 means H0 is rejected and Ha is accepted, which means that the Project-Based Learning model is effective for student engagement. Then the magnitude of effectiveness is calculated by calculating the N-gain score test, the average value of the N-gain score is 70.7864 or 70.78%, which is in the high category.
LOWER PERMIAN CONCHOSTRACANS (CLAM SHRIMPS) FROM SEDIMENTARY UNITS OF THE ATHESIAN VOLCANIC GROUP (SOUTHERN ALPS, N-ITALY)
Authors: SCHOLZE FRANK , MARCHETTI LORENZO
Published: September 2024

The present study describes two occurrences of clam shrimps (“Conchostraca”). Following a form-based classification of Schneider et al. (2005, 2022) and Schneider & Scholze (2018), the conchostracans have been classified as Pseudestheria form Oberbozen and Pseudestheria form Le Fraine. They come from the Guncina and Tregiovo formations, repectivey. These units are part of the northern Athesian Volcanic Group, North Italy. All of this material were obtained from grey coloured, fine-grained siliciclastic, lacustrine deposits of Kungurian (late Cisuralian, late Early Permian) age. Their carapace valves in lateral view are marked by concentric ribs. Often, growth lines can be observed to decrease in their preservation towards the umbonal area of the valve. An open nomenclature is applied to the taxonomy at the species level herein, because of either limited number of individuals or a plastic deformation due to tectonics. So far, the records reported herein are restricted geographically and stratigraphically to respective single occurrences. Further studies are recommended to establish their full biostratigraphic ranges.
Flexural behavior of high-strength reinforced concrete beam with hybrid fiber under normal and high temperature
Authors:   Department of Civil Engineering, College of Engineering in Al-Kharj, Prince Sattam Bin Abdulaziz University, Alkharj 11942, Saudi Arabia., Ashteyat Ahmed , Obaidat Ala ,   Civil Engineering Department, Philadelphia University, Amman 19392, Jordan., Kharabsheh Tarik ,   Jordan Standards and Metrology Organization, Amman 11194, Jordan., Harahsheh Ahmed ,   Faculty of Engineering, Department of Civil Engineering, The University of Jordan, Amman 11942, Jordan
Published: September 2024

The low cost of basalt and steel fibers makes their use in enhancing concrete properties very attractive, this paper presents experimental research on the use of Basalt Fibers (BF) and Steel Fibers (SF) and their effect on compressive, tensile, and flexural behavior of reinforced concrete beams under normal and elevated temperatures. Nineteen beams, 114 cubes, and 114 cylinders were tested to find the optimum percentage of fibers. The percentages of BF used were 1%, 2%, and 3.5% by cement weight, while the percentages of SF were 0%, 0.5%, 1%, and 1.5%. Heated samples were subjected to 600 ℃ for 3 hours and left to cool off naturally before testing. The test results show that using BF and SF significantly increased the tensile strength of unheated cylinders, with the optimum fiber content of 1% BF - 1.5% SF achieving an increase of 163% over the control. For heated cylinders, the optimum fiber content was (2% BF - 1.5% SF) achieving an increase of 175%. For compressive strength, enhancement was more modest for most of the fiber content ratios used, and the optimum mix of (1% BF - 1% SF) achieved an enhancement for unheated and heated conditions of 27% and 44%, respectively. Flexural results show that beams employing a mix of 2% BF and 1% SF yielded the most favorable result at normal temperature, enhancing the capacity by 27% compared to the control. While at high temperatures, using an optimum mix of 1% BF and 1.5% SF achieved a 27.2% increase compared to control. The use of BF and SF in concrete has also been proven to increase the ductility of the beams and has moved the failure mode from shear to flexural failure.
Finding the Units Tables of Finite Neutrosophic Rings Modulo Integers Z_n (I) for 3≤n≤16
Authors:   Department of Mathematics, University of Rijeka, City of Rijeka, Croatia, Stipan Stipan
Published: September 2024

This paper is dedicated to finding all invertible elements (algebraic units) in 14 different finite neutrosophic rings modulo integers 𝑍𝑛(𝐼) for all 3≤n≤16. We arrange the elements of the group of units of each ring in a table called the units table of the ring.
To What Extent Does Racial Discrimination Affect Blacks Working in the United States?
Authors: Chen Che
Published: September 2024

This study provides an in-depth discussion of the effects of racial discrimination in the United States on blacks when it comes to job searching and job advancement. Compared to Whites, blacks are inlcined to be more satisfied with their employment, but they have more difficulty finding jobs, and most of them are inclined to be in lower level jobs and slow to advance. Racial discrimination affects society in many ways. White racists can have a large impact on blacks so it is crucial to understand this impact. Previously, racial discrimination in the U.S. would have a large impact on the daily lives (work, participation in activities, range of socialization, living, living environment) of blacks-who generally clustered in a certain neighborhood with a crowded environment. Now, although this phenomenon has improved since the issuance of the Emancipation Proclamation in 1862, its still prevalent and there have been few changes. For this reason this essay investigates the extent to which racial discrimination affects black jobs in the United States and calls for more attention to racial discrimination and equal treatment of each race.
Future development trend of batteries for electric vehicles
Authors: Liao Zhihan
Published: September 2024

Environmental pollution and energy crisis have become the focus of global attention and urgent issues to be solved. To address these challenges, electric vehicles have emerged. Nowadays, some studies has gradually solved the problem of environmental pollution. However, these studies not note the performance issues with batteries. This article note the cruising range, the charging time and the Battery recycling and reuse technology. Thus the development of batteries will lead to a bright future.
Research on the application of the construction technology of the residential exterior wall thermal insulation structure
Authors: Lu Ziyu
Published: September 2024

The energy problem has become the main factor restricting the sustainable development of society and protecting the ecological environment. Chinas vast territory, changeable climate and environment increase the difficulty of building energy conservation and emission reduction, and restrict Chinas sustainable development strategy. It is urgent to reduce building energy consumption and improve energy utilization. The external wall insulation can effectively reduce the energy consumption of buildings. Through the analysis of the current situation of civil building wall insulation and energy-saving system, it is found that there are many problems in the construction, management and material application of external wall insulation; According to the concept of energy conservation, environmental protection and sustainable development, this paper puts forward countermeasures, hoping to have a certain reference significance for the external wall insulation construction of other similar projects.
Advances and Prospects of 3D Semiconductor Nanocomposite Materials for Solar Cells in Renewable Energy
Authors: Sun Boyang
Published: September 2024

With the escalating environmental pressures, the multifaceted characteristics of 3D materials in terms of energy utilization and stability have attracted widespread attention. This paper employs literature research, surveys, and descriptive research methods to discuss how 3D composite nanomaterials promote further innovation in new solar cells and their application in practical situations. The article mainly focuses on 2D/3D perovskite solar cells, multi-walled carbon nanomaterials, and three-dimensional ordered macroporous materials (3DOM) and deeply explores their roles in various battery frameworks. The research finds that the incorporation of 3D composite nanomaterials has promoted progress in solar cells in terms of conversion efficiency and high transmission speed, but there are still great challenges in terms of popularization and stability. It also emphasizes their far-reaching impact on promoting sustainable energy development. This paper not only provides insights into cutting-edge research but also highlights the profound impact that the development of 3D nanomaterials has on advancing sustainable energy development options. Unlocking the full potential of three-dimensional nanomaterials through interdisciplinary cooperation holds great promise for solving energy problems and creating new fields.
Microbiological Differences Among Age Groups in Patients Diagnosed With Periprosthetic Joint Infection: A Database Analysis of 2,392 Patients
Authors: Ekhtiari Seper , Mai Franka , Karlidag Taner , Gehrke Thorsten , Citak Mustafa
Published: September 2024

Introduction:

Periprosthetic joint infection (PJI) after total joint arthroplasty (TJA) poses substantial economic and quality-of-life challenges. With the rising incidence of hip and knee arthritis globally, understanding the changing profile of PJIs across different age groups becomes crucial. While various studies have explored risk factors, the influence of age on PJI remains debated, with potential bimodal relationships. This study aims to investigate the causative organisms of PJIs in patients of different age groups undergoing TJA.

Methods:

Conducted as a retrospective cohort study at a high-volume PJI referral center, the study adhered to Strengthening the Reporting of Observational Studies in Epidemiology guidelines. Data spanned from January 1, 2001, to December 31, 2022, including patients with documented PJI undergoing revision TJA. Patients were categorized into age quintiles, and outcomes analyzed included causative organisms, difficult-to-treat infections, antimicrobial resistance, and Gram stain characteristics. Statistical analyses used descriptive statistics, chi-square tests, and sensitivity analyses for hip and knee patients separately.

Results:

The study comprised 2,392 patients, with 60.7% undergoing hip arthroplasty and 39.3% undergoing knee arthroplasty. 1,080 women (45.2%) and 1,312 men (54.8%) were included. Older patients were markedly more likely to have gram-negative infections and atypical infections. Patients in the youngest age group had the lowest rates of methicillin-resistant Staphylococcus aureus infection. Results were similar between hip and knee PJIs.

Conclusions:

The study reveals age-related variations in the characteristics of PJIs after TJA, emphasizing higher risks of atypical and resistant infections in older patients. These findings underscore the importance of tailored preventive measures and potential considerations for adjunctive or prolonged antibiotic therapies, especially in the elderly population. Recognizing the unique infection patterns in older patients may inform better prevention and treatment strategies, with implications for enhanced patient care and outcomes. Future directions should focus on patient-specific strategies for preventing and treating PJIs, particularly in high-risk populations.
Detection of Eimeria Parasites in Sheeps and Goats in Alhamada Area, Libya
Authors: Amal Hmaid
Published: September 2024

Since the Alhamada area is known for its rangelands and most of its inhabitants raise animals, especially sheep and goats, this study was conducted by collecting samples randomly from six herds of sheep distributed randomly from the specific areas of Qurayat and Ghadames This study was aimed to determine the prevalance of Eimeria, which causes coccidian in sheep's and study the effects of many factors such as age, sex, and the breeding system, it is the first study conducted in the Hamada area on this parasite, using microscopic examination, 54 samples of sheep and goat feces were examined, of different ages and of both sexes in the month of May 2022. The result showed that the infection rate was 28% in sheep and 43% in goats. It was noted that there were no significant differences for age in the infection rate, as the highest infection rate was in the age group (>2) years (39%), while the lowest infection rate was in the age group of (1-2) years (7%), it was also shown that there is no significant difference for gender on the infection rate, as the infection rate in males was (22%) and females (48%). The results showed a slight difference in the infection rate between the open and closed breeding systems in the Hamada region, with the closed system averaging 25% compared to 20% in the open system. Clinical signs also appeared on some of the infected animals, including diarrhea, general weakness, and some of them showed plucking of wool/hair.
Strategi Guru dalam Meningkatkan Motivasi Belajar Siswa Pembelajaran Informatika
Authors: Mawaddah Mawaddah , Darman Darman , Saputra Hendra Nelva
Published: September 2024

Penelitian ini berfokus pada strategi guru dalam meningkatkan motivasi belajar siswa pembelajaran informatika yang merupakan aspek penting dalam keberhasilan pendidikan. Penelitian ini bertujuan untuk mengetahui bagaimana strategi guru dalam meningkatkan motivasi belajar siswa dan faktor apa saja yang sering ditemukan guru saat memberikan motivasi kepada siswa. Penelitian menggunakan metode kualitatif dengan metode observasi dan wawancara dengan guru informatika di sebuah sekolah menengah pertama di kendari yaitu SMPN 4 Kendari. Hasil penelitian menunjukkan bahwa strategi yang digunakan dalam meningkatkan motivasi belajar siswa pembelajaran informatika yaitu menggunakan pembelajaran media interaktif, project based learning (PBL), memberikan umpan balik yang konstruktif, menciptakan lingkungan pembelajaran yang medukung, memanfaatkan minat dan kebutuhan siswa, memberikan tantangan yang sesuai dan penghargaan atau pujian. Adapun faktor  penghambat yang sering di dapatkan guru saat meningkatkan motivasi belajar siswa yaitu kepribadian siswa yang tidak disiplin, sulit untuk diatur, kecerdasan siswa juga masih rendah, serta efek dari lingkungan siswa yang kurang baik dan pergaulan siswa yang tidak sehat.
Identifying Sustainable Development Goals (SDG's) on the Papua-Papua New Guinea Skouw Border as Study Material for the Development of the ASEAN Outlook on Indo-Pacific Framework: A case study in Skouw Mabo Village, Muara Tami District, Jayapura City
Authors: Pugu Melyana Ratana
Published: September 2024

This study aims to obtain an in-depth analysis of the implementation of development based on sustainable development goals on the border of Papua and Papua New Guinea, especially in the border village of Skouw Mabo, Muara Tami District, Jayapura City. that countries in the world today continue to strive to create a state of every society that lives sustainably because there are various indicators offered to achieve sustainable life known as the concept of sustainable development goals (SDG's). The SDG's is a sustainable development program prepared by UN member countries in 2015 and is expected to be achieved by 2030. This border research uses a qualitative research method, namely by collecting data directly through observation and interviews, then the data is processed by filtering various data and information obtained to then be presented in the form of an in-depth analysis of the implementation of sustainable development in the border village of Skouw Mabo. The results of the study show that the components of SDG's indicator 4 are quality education, indicator 5 is gender equality; Indicator 6 is clean water and proper sanitation and indicator 10 of the SDG's is the reduction of the gap that has not been seen in the border village of Skouw Mabo which is described quite clearly in this paper. The role of the local government, districts, cities and also community elements as well as private parties and non-governmental organizations are very necessary for the sustainability of development in this region.
Meningkatan Keaktifan Peserta Didik Menggunakan Pendekatan Culturally Responsive Teaching (CRT) pada Mata Pelajaran PKn Kelas IV Sekolah Dasar
Authors: Fatimah Suci Nuriya , Yantoro Yantoro , Misnawati Misnawati , Basyir Basyir
Published: September 2024

Tujuan dilakukan penelitian ini adalah untuk bisa meningkatkan keaktifan pembelajaran peserta didik mata pelajaran Pendidikan Kewarganegaraan melalui penerapan pembelajaran berbasis Culturally responsive Teaching. Adapun metode yang digunakan pada penelitian ini adalah Penelitian Tindakan Kelas (PTK) dengan mengadopsi model Kemiis dan McTaggart, yang dilakukan pada peserta didik kelas IV SD Negeri 042/IV Kota Jambi selama II Siklus. Adapun Hasil penelitian menunjukkan bahwa terdapat peningkatan terhadap keaktifan peserta didik dari 50, 86% pada pra-siklus menjadi 63,10% pada siklus I dan pada siklus II mendapat hasil 81,02%. Pembelajaran Culturally Responsive Teaching dapat bertujuan untuk dapat menguatkan pembelajaran pada pelajaran Pendidikan Kewarganegaraan.
Pengaruh Beban Kerja dan Kepribadian Proaktif terhadap Kinerja Karyawan Perusahaan Daerah Air Minum (PDAM)
Authors: Saputri Clariska Oktania Mega , Rini Hesty Prima
Published: September 2024

Sumber daya manusia merupakan salah satu faktor yang dapat berpengaruh terhadap tujuan suatu perusahaan. Suatu aktifitas perusahaan yang berjalan baik, tentunya dibutuhkan seorang karyawan yang memiliki kompetensi tinggi guna mencapai suatu tujuan perusahaan tersebut. Kinerja seorang karyawan sangat berpengaruh terhadap perusahaan. Apabila suatu kinerja seorang karyawan baik, maka akan berdampak baik pula terhadap perusahaan. Begitupula sebaliknya, jika suatu kinerja seorang karyawan buruk maka akan berdampak buruk pula terhadap perusahaan. Tujuan dari penelitian ini yaitu untuk mengetahui pengaruh beban kerja dan keprbadian proaktif berpengaruh terhadap kinerja karyawan bagian teknik Perusahaan Daerah Air Minum (PDAM) Kabupaten Lamongan. Penelitian ini tergolong penelitian kuantitatif dengan teknik pengumpulan data melalui penyebaran kuesioner kepada karyawan PDAM. Metode yang digunakan yaitu metide Structural Equation Modeling (SEM) berbasis komponen menggunakan alat Partial Least Square (PLS). Hasil dari penelitian ini menunjukkan bahwa beban kerja dan kepribadian proaktif berpengaruh terhadap kinerja karyawan bagian teknik Perusahaan Daerah Air Minum (PDAM) Kabupaten Lamongan.
The Role of Epigenetics in Disease and Health: Beyond DNA Sequences
Authors: Diki .
Published: September 2024

In recent decades, the field of genetics has revolutionized our understanding of biology. In particular, we know about how genetic information encodes the blueprint for life and how variations and mutations in these sequences contribute to disease or health. What is unique is that the genetic trait changes do not always caused by any changes in genetic sequences.
Epigenetics refers to the study of how environmental factors and lifestyle choices can affect the gene activity. Changes in the heritable traits of organisms can be caused by modification of gene expression rather than alteration to the underlying DNA sequence. Therefore, this change does not involve any DNA mutation.
DNA methylation is a biological process of adding a methyl group to the DNA molecule. The activity of DNA segments can change without changing the sequence by the process of methylation. This process plays an important role in normal development and aberrant DNA methylation patterns are associated with various diseases. Histones are highly basic proteins around which DNA is wound. The modifications in histone protein plays a fundamental role in most biological processes and can alter the accessibility of the DNA for transcription, as well as influencing gene expression. There are non-coding RNA molecules that do not encode proteins but play vital role in regulating the gene expression by interacting with other molecules and influencing chromatin structure.
Over the past few decades, mechanisms of epigenetics have emerged as a crucial factor in governing every biological process in the human body. Throughout human life, these mechanisms have been impacted various physiological and pathological conditions. For example, cancer is often characterized by epigenetics abnormalities, such as hypermethylation of tumor suppressor genes or hypomethylation of oncogenes. Epigenetic modifications are also implicated in complex diseases like cardiovascular disease, autoimmune conditions and neurodegenerative disorder. Beyond these diseases, epigenetics also offers insights into health and development. Furthermore, understanding the epigenetic mechanisms influence human health, leading to new preventive strategies and treatment of various diseases. Early life experiences, including nutrition and stress, can lead to epigenetic changes that affect long-term health outcomes of the individual.  
Advances in this research can pinpoint any epigenetic changes that affect long-term health outcomes. The advances of epigenetic research can lead to early diagnosis and preventive measures. Identifying the epigenetic markers associated with the diseases enable early detection of the diseases and more effective preventative strategies. Some epigenetic therapies like; drugs that modify histone acetylation or DNA methylation, are already in development and provide future treatments for disease. To understand how life style factors, influence epigenetic regulation can lead to personalized lifestyle recommendations that influence the public health strategies
Modulation of non-canonical CXCR4 and ACKR3 functions
Authors:   , Perez Almeria Claudia Victoria
Published: September 2024

The large family of G protein-coupled receptor (GPCR) family transduce extracellular signals via diverse signaling pathways to control physiological functions. They are implicated, amongst others, in cardiovascular and neurodegenerative diseases and cancer. GPCRs represent the most targeted family of membrane receptors, being targeted by around 34% of the FDA-approved drugs. GPCRs interact with different proteins leading to different intracellular signaling and trafficking.

Within the GPCR family, chemokine receptors such as CXCR4 and ACKR3 play important roles in immune surveillance, inflammation, and regulation of cell migration. CXCR4 is widely expressed across tissues and is essential for embryonic development but also highly expressed in various types of cancer. ACKR3 is notable for its role in cancer progression, influencing cell proliferation, migration, and drug resistance. In cancer, CXCR4 and ACKR3, and their shared ligand CXCL12, play critical roles in tumor growth, invasion, and metastasis, making them potential targets for therapeutic intervention in oncology and inflammatory diseases.

Research has increasingly focused on GPCRs in oncology, particularly CXCR4 and ACKR3, due to their overexpression in multiple cancers. This thesis explores the non-canonical functional consequences of these receptors in a cancer setting using distinct CXCR4 and ACKR3-directed nanobodies.

CXCR4-targeting nanobodies have been used to modulate CXCR4 oligomerization and consequently study the functional consequences of these oligomers. We could disrupt CXCR4 oligomers, monomerizing CXCR4, or further induce CXCR4 oligomers. These tools aided us to validate that CXCR4 oligomers activate the oncogenic JAK2/STAT3 signaling pathway.

Different approaches have been taken to study ACKR3. First, different phosphorylation mutants in ACKR3's C-terminal tail were generated to understand the importance of phosphorylation in β-arrestin recruitment and trafficking. We showed that distinct residues within the C-tail of ACKR3 differentially regulate CXCL12-induced β-arrestin recruitment, ACKR3 internalization and trafficking. Second, ACKR3-targeting nanobodies with different modes of action were employed to explore the basal activity of ACKR3. Structural analysis of nanobody-bound ACKR3 is carried out to assess their effects at a molecular level. Lastly, we initiated studies using CRISPR-Cas9 tools in a cancer cell line and Turbo-ID as proximity labelling enzyme, to gain deeper insight into its function in a cancer setting under basal conditions. Here, putative interacting partners of ACKR3 are identified which may play a role in basal activity of ACKR3 in cancer cells.

The findings underscore the significance of GPCRs, particularly CXCR4 and ACKR3, in cancer biology, emphasizing their potential as targets for novel therapies and providing insights into their molecular mechanisms in cancer cells.
Exploração dos avanços em tecnologia robótica e suas aplicações em diferentes tipos de cirurgias: uma revisão integrativa
Authors: Pereira Fagner Marques , Delatore Camilla Spindola , Castro Filho Jaques Adriano de , Silva Anna Luiza Barbosa Ribeiro de Sales , Nascimento Lívia , Lima Vitor Oliveira , Oliveira Gustavo Mendonça de , Balula Aline Martins , Laignier Neto Ely Francisco , Silva Acsa Rhayenne de Morais , Marinho Taynara Gonçalves , Marques Lindolfo Gabriel Justa
Published: September 2024

Esta revisão integrativa explora os avanços em tecnologia robótica e suas aplicações em diversos tipos de cirurgias. A cirurgia robótica, iniciada com o sistema da Vinci, tem transformado a prática cirúrgica ao oferecer maior precisão, controle e menos invasividade. Os principais avanços incluem melhorias na visualização tridimensional, maior precisão nos movimentos e a introdução de feedback háptico e inteligência artificial. A tecnologia tem mostrado benefícios em áreas como urologia, ginecologia, cardiovascular, gastrointestinal e ortopédica, com evidências de melhor recuperação e menos complicações comparadas às técnicas tradicionais. No entanto, desafios como altos custos e a necessidade de treinamento especializado ainda limitam sua adoção ampla. Para pesquisas futuras, recomenda-se a análise de resultados a longo prazo, a redução dos custos e a expansão do treinamento em tecnologia robótica. A integração com tecnologias emergentes, como realidade aumentada, pode potencializar ainda mais os benefícios da cirurgia robótica.
PREVALÊNCIA DE INCONTINÊNCIA URINÁRIA NO ESTADO DE GOIÁS (2008-2024)
Authors: Lemos Isabella Gomes Machado , Biella Ana Flávia de Carvalho Lima , Miura Mariana Paixão Freitas , Correia Ludmila Neris , Nascimento Thaylla Horbylon , Barcelar Clara Steffany Araujo , Lima Lucas Victor de , Almeida Nathalia Bandeira de
Published: September 2024

Este estudo aborda a prevalência de incontinência urinária (IU) no estado de Goiás de 2008 a 2024, com o objetivo de analisar as tendências temporais e espaciais da condição. Utilizando dados do sistema TabNet do DataSUS, a pesquisa calculou a prevalência anual de IU em diferentes cidades, identificando a cidade com a maior prevalência em 2024 e examinando as variações ao longo dos anos. A análise estatística, que incluiu regressão linear, revelou um aumento geral na prevalência de IU em Goiás, com Goiânia apresentando a maior prevalência em 2024, seguida por Anápolis e Aparecida de Goiânia. A tendência de aumento foi significativa em todas as cidades, sugerindo um crescimento consistente da condição. Conclui-se que a incontinência urinária está em ascensão no estado, destacando a necessidade de políticas públicas e intervenções direcionadas para as regiões com maior prevalência.
ASSOCIAÇÃO DA DISFUNÇÃO SEXUAL COM SINTOMAS DEPRESSIVOS EM PUÉRPERAS DE ABORTO
Authors: Silva Letícia Danielly Tenório , Brito Luana Mayara Tenório de , Gomes Filho Sérgio Luiz da Rocha , Magalhães Edilane Jales Leite , Marques Maiara Bernardes , Gilly Daphne
Published: September 2024

Objetivo: investigar a associação da disfunção sexual com sintomas depressivos em puérperas de aborto. Métodos: trata-se de um estudo do tipo revisão de literatura onde foi realizada uma busca referente ao tema abordado em artigos publicados nas bases de dados Bireme, Pubmed, Lilacs e SciElo, no período de 2005 a 2023. Os estudos foram pré-selecionados por meio da leitura dos artigos na íntegra e aplicados os critérios de inclusão e exclusão. Resultados: somando todas as bases de dados, foram encontrados 250 artigos. Após a leitura dos artigos, notou-se que 62,4% (n=146) não preenchiam os critérios do presente estudo e 92,05% (n=81) não correspondiam ao tema. Sendo assim, restou um total de 7 fontes que contextualizavam o assunto de interesse, onde 28,6% (n=2) analisaram a disfunção sexual feminina, 57,14% (n=4) o treinamento dos músculos do assoalho pélvico e 14,3% (n=1) observaram a relação entre o aborto e a depressão. Conclusão: conclui-se que a fisioterapia no período puerperal do aborto é uma prática ainda não estabelecida nos hospitais maternidade, e espera-se que o presente artigo beneficie a comunidade acadêmica a respeito do tema, os profissionais de saúde que diariamente lidam com esse público e as mulheres que sofreram aborto.
Evaluasi Kelembagaan Kota Samarinda Berdasarkan Kebijakan Penataan Kelembagaan Pemerintah Daerah : Studi Kasus pada Dinas Kesehatan Kota Samarinda
Authors: Sartika Dewi , Rustan amarullah  , Kemal Hidayah  , Fani Heru Wismono  , MARIA AGUSTINI PERMATA SARI  , Mayahayati Kusumaningrum  , Tri Noor Aziza  , Tri Wahyuni  , Novi Prawitasari  , Ricky Noor Permadi
Published: September 2024

Perubahan lingkungan strategis dan peraturan yang dinamis merupakan tantangan sekaligus peluang bagi pemerintah kota untuk merumuskan dan menyusun kebijakan organisasi yang sejalan dengan arah pembangunan. Penataan organisasi perangkat daerah adalah hal biasa dalam suatu siklus organisasi, termasuk dalam organisasi pemerintah daerah. Dengan penyederhanaan organisasi, Pemerintah daerah tersebut diharapkan kinerja pemerintah daerah menjadi lebih efektif dan efisien. Penataan kelembagaan tidak terbatas pada nomenklatur, tapi juga berdampak pada tata kelola koordinasi, ruang lingkup pekerjaan, pengelolaan sumber daya, dan lain lain. Dengan menggunakan kriteria penataan kelembagaan dari perspektif kebijakan penganggaran, menganalisis nilai isu strategis terkait visi dan misi daerah serta program unggulan daerah, analisis preskripsi model dan nomenklatur kelembagaan daerah, menganalisis tipologi urusan, yang kemudian ditawarkan menjadi dua model, yaitu: 1) Model Kelembagaan Progresif dan 2) Model Kelembagaan Pragmatis. Singkatnya, perbedaan dari model kelembagaan alternatif secara mendasar mengubah kelembagaan yang ada, tetapi tetap mengutamakan faktor kunci dalam pencapaian tujuan pemerintah daerah. Di sisi lain, pilihan model pragramatis merepresentatifkan model kelembagaan yang moderat, realistis, dan rasional, namun kedua model alternatif tersebut tetap tetap menawarkan struktur yang lebih ramping dan alokasi sumberdaya yang lebih efisien. Dimungkinkan untuk memilih model hybrid, dengan mempertimbangkan intesitas beban kerja, dan mengoptimalkan kinerja program unggulan.
INFORMATION DETECTION OF BID-ASK SPREAD AND FIRM SIZE ON EARNING MANAGEMENT WITH GOOD CORPORATE GOVERNANCE AS A MODERATING VARIABLE
Authors: Putri Roostina Nugrahani
Published: September 2024

The objective of this research is to examine how bid-ask spread and company size impact earnings manipulation, with effective corporate governance acting as a moderating factor. This research employs a quantitative method by analyzing secondary data sourced from the annual reports of manufacturing businesses that are publicly traded on the Indonesia Stock Exchange (IDX) between 2018 and 2022. Samples were collected using purposive sampling with specific criteria. The results showed that a larger bid-ask spread can result in more earnings manipulation, while company size does not significantly affect earnings manipulation. Good corporate governance affects the bid-ask spread and earnings management relationship, but not the company size and earnings management relationship. This study highlights the significance of implementing good corporate governance in reducing earnings management practices and advises investors to consider corporate governance before investing.
Petsamon Kalastajasaarennon siviilisotavankien kovat kokemukset
Authors: Lähteenmäki Maria
Published: September 2024

Artikkelissa kartoitetaan ja arvioidaan Suomen pohjoisimmalle raja-seudulle, Petsamon Kalastajasaarennolle, jääneiden suomalaisten kohtaloita Neuvostoliiton hyökätessä seudulle talvisodan alka-essa marraskuun lopussa 1939; miten paikalliset ihmisetselvisivät sotatoimien vyöryessä yli. Seudun asukkaat olivat pää-osin niin sanottua tavallista, pienillä tiloilla tai palveluamma-teissa toiminutta palkkatyöväkeä, kalastajia ja perheenäitejä, sekä saamelaisia että suomalaisia. Heidän ammateikseen on merkitty muun muassa talousapulainen, emännöitsijä, kaupanhoitaja, lau-tamies, työmies, kalastaja ja poromies.
Venäjän historia ja tutkimuksen tulevaisuus
Authors: Mikkonen Simo
Published: September 2024

Päätäntöessee vetää yhteen artikkelikokoelman teemoja sekäpohtii Venäjä-tutkimuksen tilannetta Venäjän aloittamanUkrainan hyökkäyssodan aikana sekä tulevaisuudessa.
Longevity Through Storytelling: The Silver Passport Case Study
Authors: Rosakebia Estela
Published: September 2024

The Silver Passport Case Study investigates the preservation and dissemination of collec-tive wisdom through storytelling, focusing on the active engagement of older adults as knowledge sharers. This initiative addresses the digital divide among older adults in Peru, fostering intergenerational connections through innovative methodologies for capturing and sharing personal histories. The study details the project's inception, implementation, and impact, underscoring its role in enhancing social inclusion and emotional well-being among senior participants. The primary results indicate notable improvements in digital literacy, social connectivity, and emotional health among the older adults. The project ef-fectively bridged generational gaps and fostered mutual understanding between age groups. Future research should explore the long-term effects of digital storytelling on so-cial inclusion and psychological health across different cultural contexts. This exploration is essential for developing strategies to address the challenges of aging populations and the digital divide. Keywords: storytelling, digital inclusion, intergenerational connections, senior engage-ment, collective wisdom, emotional well-being
Critical Analysis of Obstetric Interventions: Perspectives from the ARRIVE Trial and Subsequent Findings in Slovenia
Authors: Smerkolj Kaja , Verdenik Ivan , Kornhauser Cerar Lilijana , Lučovnik Miha , Jeran Marko
Published: September 2024

The quest for optimal maternal and neonatal outcomes in midwifery and obstetrics revolves around the timing of labor induction, a subject of ongoing debate. The ARRIVE trial (A Randomized Trial of Induction Versus Expectant Management) furthered this discourse by comparing labor induction with expectant management, revealing reduced cesarean section rates and improved perinatal outcomes with induction. Concerns arose regarding the generalizability and potential biases of the ARRIVE trial's findings. European studies questioned the applicability of its findings to their populations, given demographic disparities. Despite varied results on cesarean section rates, Cochrane reviews affirmed induction's positive impact on perinatal outcomes. However, recent studies indicated increased risk for cesarean delivery for low-risk nulliparous women undergoing induction. Following the publication of the ARRIVE trial, obstetric practices worldwide experienced a notable shift towards earlier inductions. However, our own study, conducted across all 14 Slovenian hospitals, indicates a rise in labor induction rates that does not correspond with the timeline of the ARRIVE trial's publication. Specifically, the trend of inducing labor in women whose labor started spontaneously in Slovenia is concerning, suggesting a trend towards medicalization of labor. Considering the complexities surrounding the ARRIVE trial, recommendations suggest a balanced approach. Healthcare providers should offer comprehensive information, including trial findings and limitations, empowering women to make personalized decisions. This patient-centered approach ensures optimal outcomes while acknowledging the nuances of individual circumstances. Keywords: Labor induction, Low-risk pregnancy, Gynecology and obstetrics, ARRIVE trial, Healthcare, Slovenia
Analysis of The Strengths and Weaknesses of Burai Tourism Village in Ogan Ilir Regency
Authors: Prima L , Amalia F , Ulfa A , Berlian M N , Prayoga Aziz F A , Rahmadhino N
Published: September 2024

Burai Village, situated in Tanjung Batu District, Ogan Ilir Regency, South Sumatra Province, has been classified as a tourist village since 2018. The village's economy, which heavily depends on tourism, has been adversely affected by the Covid-19 pandemic. This situation has hindered the village's ability to utilise its significant potential fully. The objective of the research is to analyse the strengths and weaknesses of the village, serving as a foundation for exploring its potential for development. The research utilises qualitative methods, interviews, and SWOT analysis. The findings from this analysis can be used to maximise the tourism potential in Burai Village and other tourist villages across Indonesia. Ultimately, the goal is to uncover and revitalise Burai Village's potential as a tourist destination.
“Born in the first light of the morning”: Feminist pedagogy in art museums and exhibitions toward a new professional development of care
Authors: Luraschi Silvia , Del Negro Gaia
Published: September 2024

We share our own experiences of visiting exhibitions as a practice of feminist pedagogy and how we used them to help master students in a residential care programme in Master in the University of Milano Bicocca to expand their thinking about the idea of care. We reflect on how the idea of taking up ‘care’ as (dis)connections to the land based on an experience of visiting First People’s House at the University of Victoria, and returns to childhood sites of memory. Using one particular art exhibition by Dineo Seshee Bopape’, who uses organic materials to explore concepts of land, memory, identity, and colonialism, we discuss how this exhibition actually enabled new thinking as witnessed in the research dairies kept by four students. Based on diary entries we developed I-poems to show how understandings of care had expanded using art and exhibitions to break boundaries of normative thinking.
Afro-Caribbean women and resistance An exploration of decolonial feminist pedagogies in the Women's Museum Costa Rica
Authors: Mandelkatz Claudia
Published: September 2024

As a professor and founder of the Women's Museum Costa Rica I explore in this article how exhibitions help us in our pedagogical mission of a new decolonial gender awareness. Specifically, I analyze a number of selected artworks in online exhibition titled Memories and resistances. Women, artists, Afro-America and Caribbean stories in terms of how they make visible and represent women of Afro-descendants as complex political subjects. My findings show that this exhibition operated very effectively as an instrument of feminist decoloniality, by addressing the matrix of gender and race oppression, recovering different stories of women and memories of historical resistances, and offering a more collective sense of identity and agency. By curating exhibitions like this, our women's museum can play a crucial role in providing new anti-racist, anti-traditional and anti-patriarchal perspectives that educate current and younger generations about the histories and lives of women who have long been ignored.
CONCEPTUAL VOCABULARY AMONG PRESCHOOLERS
Authors: Mancilla-Martinez Jeannette
Published: September 2024

This study examined Spanish-English preschoolersâ€™ (n = 32) vocabulary performance when using traditional English-only compared to those that utilize conceptual scoring (i.e., vocabulary knowledge in terms of known concepts independent of whether the label for the concept is known in either Spanish or English) designed for and normed on Spanish-English bilinguals. Childrenâ€™s performance at the item level on the conceptually-scored measures was also examined. In English, receptive and expressive average scores were in the below-average ranges. However, on the conceptually-scored vocabulary measures, the average scores were within the average range, receptively and expressively. Examination of childrenâ€™s performance at the item level suggests there may be differences by language in bilingual childrenâ€™s receptive and expressive vocabulary performance. The findings underscore the value of utilizing conceptually-scored vocabulary measures, suggesting that their use may have potential for differentiating language difference from language disorder among young bilingual learners.