bluuebunny/crossref_metadata_2025 huggingface dataset:
Machine Learning-Enhanced Evaluation of Neuroleptics Efficacy and Management in Schizoaffective Disorder
Authors:   Neuroscience, Institute of Psychopathology, Rome, Italy, Filippis Rocco de , Foysal Abdullah Al ,   Computer Engineering (AI), University of Genova, Italy
Published: December 2024

Background
Neuroleptics or antipsychotic medications are widely used in the treatment of various psychiatric disorders. However, they have
been associated with the secondary development of obsessive-compulsive symptoms (OCS) in some patients. This case report
examines two patients who developed obsessive-compulsive aspects secondary to neuroleptic treatment, analysed using visual
data representations and machine learning.
Objective
To evaluate the development of OCS in patients treated with neuroleptics and to analyse their clinical outcomes using Y-BOCS
and CGI-S scores, complemented by machine learning predictions.
Methods
Two patients treated with neuroleptics were assessed for the emergence of OCS using the Yale-Brown Obsessive Compulsive
Scale (Y-BOCS) and Clinical Global Impression-Severity (CGI-S). Data were collected before and after the onset of OCS, and
visualizations were employed to illustrate symptom progression and treatment effectiveness. Machine learning techniques were
applied to predict OCS outcomes.
Results
Both patients developed significant OCS after the initiation of neuroleptic treatment. Their Y-BOCS and CGI-S scores increased,
indicating the emergence and severity of OCS. Following treatment adjustments, both patients showed marked improvement in
their scores. Machine learning models provided additional insights into the factors influencing OCS development.
Conclusion
These findings highlight the potential for neuroleptics to induce secondary OCS in patients, necessitating careful monitoring
and management of these symptoms. Visual data analysis and machine learning provide powerful tools to understand and
communicate these clinical changes.
Predictive Analysis of Neuroleptics-Induced Obsessive-Compulsive Symptoms Using Machine Learning
Authors:   Neuroscience, Institute of Psychopathology, Rome, Italy, Filippis Rocco de , Foysal Abdullah Al ,   Computer Engineering (AI), University of Genova, Italy
Published: December 2024

Background
Neuroleptics, or antipsychotic medications, are widely used in the treatment of various psychiatric disorders. However, they
have been associated with the secondary development of obsessive-compulsive symptoms (OCS) in some patients. This case
report examines two patients who developed obsessive-compulsive aspects secondary to neuroleptic treatment.
Objective
To evaluate the development of OCS in patients treated with neuroleptics and to analyse their clinical outcomes.
Methods
Two patients treated with neuroleptics were assessed for the emergence of obsessive-compulsive symptoms using the Yale-Brown
Obsessive Compulsive Scale (Y-BOCS) and Clinical Global Impression-Severity (CGI-S). Data were collected before and after
the onset of OCS.
Results
Both patients developed significant OCS after the initiation of neuroleptic treatment. Their Y-BOCS and CGI-S scores increased,
indicating the emergence and severity of OCS. Also include the bar plots, line plots, pair plots, heatmap, and box plots to present
the findings visually. Explain each plot in the context of the patients' symptom progression and treatment adjustments.
Conclusion
These findings highlight the potential for neuroleptics to induce secondary obsessive-compulsive aspects in patients, necessitating
careful monitoring and management of these symptoms.
Device for Signaling and Blocking Unauthorized Voltage Supply to a Rural Electrical Network and Its Reliability
Authors:   FGBNU FNATS VIM, Vinogradov A.V. , Panfilov A.A. ,   Oryol State Agrarian University, Vinogradova A.V. ,   FGBNU FNATS VIM
Published: December 2024

The article deals with the issues of danger and the main probable causes of unauthorized voltage supply in rural electrical networks. The variants of signaling and blocking devices from reconversion at 10/0.4 kV transformer substations in case of unauthorized voltage supply to the substation buses or to the outgoing 0.4 kV lines are given. The device of the USBOT-PK type meant for signaling and blocking from reconversion is considered and the principles of its application are shown. The calculation of the main reliability indicators of the USBOT-PK device is performed.
Determining the Contact Patch Area of Tires of Tractors and Agricultural Machinery
Authors:   Rosinformagrotech, Revenko V.Yu.
Published: December 2024

The results of the analysis of the existing methods of determining the contact patch area of the tractor and agricultural machinery tires are presented, the need to develop a new method and technical means for determining the contact patch area is substantiated.
La Estrategia de recuperación de activos: El enriquecimiento ilícito, El lavado de activos y el comiso, Algunas pinceladas sobre la Legislación ecuatoriana y española
Authors: Vélez-Zhindón María Teresa
Published: December 2024

El "Derecho penal moderno" ha generado una cierta "desarmonización del Derecho penal", dando lugar a la creación de "nuevos tipos penales",  técnicas de tipificación que se asemejan a modelos sancionatorios del Derecho administrativo. Un ejemplo de ello es el delito de enriquecimiento ilícito en modalidad de desobediencia, como pretende clasificarlo el legislador español. Esta tendencia también se observa en la desnaturalización de consecuencias accesorias, como el decomiso ampliado en la legislación española. Además, la tipificación de delitos como el enriquecimiento ilícito y el lavado de activos refleja un enfoque que sanciona conductas postdelictivas, tanto el legislador ecuatoriano como el español han optado por procedimientos procesales que facilitan la persecución de delitos en los que no es posible determinar el origen delictivo del incremento patrimonial. Este origen se considera “inexplicable” o “injustificado” y se presume que proviene de un delito previo, este enfoque nos lleva a cuestionar si, en el contexto del "Derecho penal moderno", la recuperación de activos de origen ilícito, basada en presunciones de culpabilidad o de activos de origen ilícito, puede justificar una sentencia condenatoria o el decomiso de activos.
Sistema de Rehabilitación Social: Hacia un modelo que promueva la reinserción
Authors: Ochoa-Rodríguez Guillermo Alejandro , Tamariz-Eguiguren Mikaela Paola , Palacios-Miño Valentina
Published: December 2024

El sistema penitenciario de los países latinoamericanos y especialmente refiriéndonos al Ecuador se ha caracterizado por presentar factores sociales que potencian la delincuencia como: la pobreza y la creación de grupos delictivos. Estos han generado los siguientes problemas que perturban el sistema penitenciario: hacinamiento, mega cárceles, violencia y corrupción.  Ante la preocupación internacional sobre la crisis penitenciaria en Ecuador, la Comisión Interamericana de Derechos Humanos (CIDH) realiza una visita técnica ante la latente inseguridad e incertidumbre presente en el país. Con este informe se realiza una interpretación de las diferentes recomendaciones emitidas por la CIDH y las medidas adoptadas por el Estado Ecuatoriano. Finalmente, se toma a la reinserción como punto medular que busca la reintegración de los privados de libertad de una manera positiva en la sociedad.
La Dignidad Humana: Principio y Fin del Derecho y del Orden Social
Authors: Jaramillo-Malo Santiago
Published: December 2024

El presente trabajo analiza y busca demostrar que la dignidad humana debe ser el fundamento y razón de ser del derecho. Si bien a partir de la post guerra el mundo, básicamente occidental, dio un giro en su mirada hacia el ser humano, no solo en lo jurídico sino en lo político, social y económico, esta mirada ha estado encaminada a desarrollar, garantizar y construir los derechos humanos, desde los llamados de primera generación, hasta lo que hoy conocemos como emergentes. Sin embargo, ningún derecho que pueda reconocerse y garantizarse en favor de las personas, tendría razón de ser si no miramos y reconocemos profundamente a la dignidad, que más que un derecho, es una condición intrínseca a toda persona humana por el solo hecho de ser y existir. Es así que la dignidad humana permea a todos los demás derechos siendo por tanto principio, fin y fundamento, no solo del derecho sino de todo orden político, económico y social. Este trabajo desarrolla básicamente lo que el profesor Alfonso Santiago ha denominado como “el principio de la igual e inviolable dignidad de la persona humana” (Santiago, 2022), para que se convierta en faro iluminador de la convivencia y el desarrollo de las naciones.
4to Congreso Virtual de Microcontroladores y sus Aplicaciones
Authors: Paraná UTN Facultad Regional
Published: December 2024

Cuarto Congreso Virtual de Microcontroladores y sus Aplicaciones
Con participación de la comunidad técnica de habla hispana del Continente
Con los siguientes objetivos

Abrir un espacio de reflexión y debate sobre el uso de microcontroladores como solución a problemas y desarrollo de productos.
Fomentar el desarrollo tecnológico y la investigación.
Promover mediante este tipo de encuentro la calidad y actualización académica.
Divulgar modelos y tendencias tecnológicas.
Promover el intercambio institucional, profesional y personal entre todos los participantes respecto de experiencias, métodos y desarrollos de su trabajo con microcontroladores y sistemas embebidos.
Generar un espacio de discusión de amplia cobertura sobre la temática.
Difundir en el ámbito profesional y académico las tecnologías asociadas a los sistemas microcontrolados.
Fomentar la interacción industria-academia en temas asociados a los sistemas microcontrolados.
Incentivar entre los estudiantes universitarios y los jóvenes profesionales el interés por los sistemas de control digital microcontrolado.
Permitir un mayor acceso de los interesados a este conocimiento, sin importar la ubicación geográfica que los mismos tengan.

 
Comité Organizador
Coordinador
Ing. Raúl Manuel Caballero
Colaboradores
Ing. Enrique Sergio Burgos
Ing. Alejandro Raúl Dachary
Ing. Pablo Javier Suculini
Ing. Rubén Adrián Britos
Ing. Gustavo Daniel Maggiolo
Sr. Joaquín Leikam
Sr. Darío Hernán Klug
 
Eje Temático:

Aplicaciones en Bioelectrónica
Aplicaciones en Conectividad y Comunicaciones
Aplicaciones en Ecología
Aplicaciones en Educación y Enseñanza
Aplicaciones de uso Hogareño
Aplicaciones en Inteligencia Artificial
Aplicaciones en la Industria y Control de Potencia
Aplicaciones de Internet de las Cosas (IoT)
Aplicaciones en Robótica
Aplicaciones en Seguridad
Aplicaciones en Software
A problemática da adoção de tecnologias de produção agrícola: Uma análise das relações de poder baseadas no género, no Distrito de Barué, Moçambique
Authors: Cau Henrique , Langa Patrício
Published: December 2024

Este artigo tem como objetivo compreender se as relações de poder baseadas no género têm alguma influência sobre as decisões que os agricultores familiares tomam em relação a adoção das tecnologias que aprendem nas Escolas na Machamba do Camponês (EMCs) no Distrito de Barué, em Moçambique. Trata se de uma pesquisa com uma abordagem qualitativa e método de pesquisa Estudo de Caso e foi realizada no distrito de Barué, província de Manica, Moçambique e foram entrevistados 12 produtores familiares integrados nas Escolas na Machamba do Camponês (EMC), que é uma metodologia usada pelo Fundo das Nações Unidas para Alimentação (FAO) para transferir tecnologias agrícolas resilientes às mudanças climáticas para os agricultores da região centro de Moçambique. O estudo revela a existência de espaços de manifestação de exercício de poder baseadas no género caraterizadas pela partilha de responsabilidades entre mulheres e homens quando se trata da decisão sobre adoção de uma determinada tecnologia. . A natureza e o tipo de tecnologia são fatores determinantes no exercício de poder de decisão.
Avaliação da saúde física e mental de uma idosa com sintomas de depressão: Um relato de experiência
Authors: Moura Beatriz de Lima , Abreu Marcelly da Conceição Silva Seixas , Rosário Julianne Beathriz Abdon do , Santos Fabiana Souza dos , Rocha Neto Miguel Barros da , Moreira Mariana Rodrigues
Published: December 2024

O objetivo deste trabalho foi desenvolver e implementar um plano de cuidado interdisciplinar para uma idosa de 80 anos com sinais de depressão, visando melhorar sua qualidade de vida. O cuidado buscou fortalecer sua autonomia, bem-estar físico e emocional, e reintegração social, considerando suas necessidades e particularidades. O estudo foi realizado no contexto da disciplina IESC do curso de medicina da Faculdade AFYA Bragança, por meio de visitas domiciliares com os Agentes Comunitários de Saúde (ACS), entre agosto e outubro de 2024. A coleta de dados envolveu anamnese, exames físicos, e a aplicação de escalas como a Escala de Depressão de Beck, o Índice de Vulnerabilidade Clínico Funcional-20 e o Teste de Timed-up and Go. Além disso, foram usados o genograma, ecomapa e o APGAR-familiar para analisar o contexto social da paciente. Os resultados indicaram que a idosa apresentava sintomas de depressão moderada e fragilidade, mas sem risco elevado para quedas. O plano de cuidados inclui metas de curto, médio e longo prazo, como estímulo à atividade social, apoio psicológico e adesão a tratamentos médicos. O Projeto Terapêutico Singular mostrou ser eficaz na identificação de problemas de saúde mental e na articulação da rede de cuidados, promovendo uma abordagem integral e humanizada.
A rotina do autocuidado em estudantes de graduação durante a pandemia do Covid-19
Authors: Oliveira Jessika Pricilla Ferreira de , Ary Maria Luiza Morais Regis Bezerra
Published: December 2024

Introdução: Autocuidado à saúde representa muito mais do que a capacidade do indivíduo de “fazer coisas” por si e para si mesmo. A pandemia do Covid-19 marcou as pessoas com o distanciamento social, mudança do cotidiano e da rotina das pessoas, trazendo assim questionamentos, preocupações, medo, tornando tudo muito instável. Objetivo: Identificar se a rotina do autocuidado dos estudantes de graduação sofreu mudanças na pandemia do covid-19. Metodologia: Este é um estudo de abordagem quantitativa, de natureza descritiva e modo transversal. Participaram dessa pesquisa estudantes do curso de terapia ocupacional estudantes de uma universidade estadual do nordeste brasileiro. O estudo foi realizado de forma online, onde um link foi disponibilizado via e-mail e whatsapp com o questionário. Na coleta de dados utilizou-se algumas perguntas para identificação e a Escala de avaliação da capacidade de autocuidado- EACAC (ASA-A). Utilizamos uma análise simples e descritiva. Resultados/discussão: O resultado geral da escala mostra resultados proveitosos, entretanto nas questões individuais houve pontos significativos de destaque a serem mencionados. Os estudantes não conseguiram manter uma rotina no autocuidado, sendo a alimentação, o sono e o tempo para si mesmos as áreas mais afetadas. Conclusão: A pandemia do Covid-19 causou alterações na rotina de autocuidado dos estudantes. Apesar desses estudantes não precisarem se deslocar à Universidade devido a virtualização das aulas, eles não conseguiram estabelecer um planejamento para o desenvolvimento de uma rotina de autocuidado satisfatória.
Diversidade de recursos vegetais utilizados por agricultores familiares em Altamira, Pará
Authors: Silva Cintia Correa e , Rufino Elias Souza , Pinheiro Johnny Sales , Pessoa Thaynara Sabrina Santos , Silva Maristela Marques da
Published: December 2024

Este estudo teve como objetivo identificar a diversidade de recursos vegetais utilizados por agricultores familiares no Projeto de Assentamento Assurini, no município de Altamira, Pará. A pesquisa foi realizada na comunidade Dispensa e comunidade Gorgulho da Rita, sendo entrevistadas 17 famílias durante o mês de outubro de 2023 e março de 2024. As famílias utilizam uma diversidade de recursos vegetais na dinâmica familiar, sendo citadas 131 espécies vegetais. As espécies são obtidas em diferentes locais, como os quintais (67,93%), com incidência de plantas frutífera e medicinais, nas roças (11,45 %), nas capoeiras (11,45%) e nas matas (9,6%). Essas espécies são utilizadas para fins medicinais, alimentícios e outros usos como a fabricação de equipamentos que são utilizados nas roças. Sendo muito importante divulgar a importância da manutenção e preservação destes saberes que contribuem na qualidade de vida, segurança alimentar das famílias e na biodiversidade no Assentamento.
Sífilis Congênita no Brasil: Uma análise do perfil epidemiológico de 2013 a 2022
Authors: Santos Mariana Castro Mesquita dos , Santana Amanda Rafaella Silva , Santos Neto Belmiro Firmino dos , Abud Ana Carolina Freire , Silva Marcos Alexandre Santiago , Oliveira Halley Ferraro
Published: December 2024

A Sífilis Congênita (SC) é causada pela transmissão vertical da bactéria Treponema pallidum, e ocorre em qualquer período gestacional e estágio da doença materna. A detecção precoce durante os cuidados pré-natais é essencial para um rápido início do tratamento, com intuito de prevenir danos ao desenvolvimento infantil. Esse estudo identifica e analisa as variáveis que interferiram no aumento das taxas de SC, e tem o objetivo de compreender o perfil epidemiológico dessa doença no Brasil, no período de 2013 a 2022. Foi desenvolvido um estudo ecológico de série temporal, descritivo e quantitativo usando dados disponibilizados pelo Departamento de Informática do Sistema Único de Saúde (DATASUS), nas seções do Sistema de Informação de Agravos de Notificação (SINAN) e do Sistema de Informações sobre Nascidos Vivos (SINASC), via TABNET. Observou-se um número elevado de casos de SC no Brasil, com resultados que ultrapassam os valores preconizados pela Organização Mundial da Saúde (OMS). A análise sociodemográfica demonstrou uma maior incidência em crianças pardas, de até seis dias de vida, filhos de mulheres com baixa escolaridade que realizaram pré-natal. Assim, tal cenário aponta tanto para uma falha na assistência ao diagnóstico, quanto para um programa precário de tratamento para a sífilis gestacional no Brasil, visto que, mesmo com o pré-natal realizado, esses casos ainda aumentaram. A desigualdade social, portanto, mostra-se como um fator significante no aumento da incidência da SC, o que indica a necessidade de uma oferta justa e igualitária desse serviço, como uma medida essencial.
On the Uses and Abuses of Psychological Research in Moral Philosophy
Authors:   , Rehren Paul Heinrich Peter
Published: December 2024

Recent decades have seen a steep increase in the numbers of moral philosophers who cite, engage with and make serious use of empirical research from psychology and its neighbouring disciplines. These are welcome developments; however, they also come with considerable new challenges.

The First Challenge is to make the case that these developments are not fundamentally wrong-headed. Moral philosophy, so goes the objection, operates in normative space. Moral philosophers are in the business of figuring out how humans ought to live, think and act in the world. Yet it is impossible to derive an ‘ought’ statement from an ‘is’ statement, and so empirical premises do not in fact (and could not) play any significant role in moral philosophy. The moral philosophers who aim to incorporate more be behavioral science into their own work are therefore either misguided, incompetent or both.

To addresses the First Challenge, Walter Sinnott-Armstrong and I argue that, as a matter of fact, lots of work in moral philosophy relies on assumptions about how people think, feel and act (chapter 3). Therefore, there are many lessons that disciplines like psychology, neuroscience, experimental economics and cognitive anthropology have to teach moral philosophers. We illustrate our argument using the case study of the reliability of moral judgments and decisions.

The Second Challenge is to bridge the gap between empirical research and philosophical argument. It is one thing to recognize that an argument relies on assumptions about how people think, feel or act, and so needs empirical support. It is another thing to then make a convincing empirically-informed case for these assumptions. To achieve this, there are a series of inferential gaps between these assumptions and the (quantitative) research that need to be bridged. In my thesis (chapters 4-6), I focus on four of these inferential gaps: construct validity; effect size; generalizability; and causal inference from observational data. I further illustrate, explain and discuss each gap with the help of two case studies from the literature on the causes of large-scale moral progress.

In the final chapter, I summarize the main points of the thesis. I then argue that three of the four challenges discussed throughout the thesis (construct validity; generalizability; effect size) are not just of concern in the literature on the causes of moral progress, but likely affect empirically-informed arguments in many other areas of philosophy, as well. To make this case, for each challenge, I highlight a series of additional examples where empirically-informed arguments failed (or have been argued to fail) due to not meeting that challenge. I then argue that these examples and other examples like them are to be expected given the types of questions philosophers seek to answer and the approaches they tend to use to answer these questions. I conclude that if this picture is approximately correct, then empirically-informed philosophy faces a crisis.
Analysis of Tax Extensification and the Role of Renjani in Increasing Individual Taxpayer Compliance
Authors: Ayu Lestari Pratiwi  , Sonny Pangerapan  , Syermi Mintalangi
Published: December 2024

ABSTRAK
Penelitian ini bertujuan untuk menganalisis Ekstensifikasi Pajak dan peran Renjani dalam rangka meningkatkan Kepatuhan Wajib Pajak Orang Pribadi. Penelitian ini menggunakan pendekatan kualitatif dengan metode wawancara sebagai sumber data primer. Hasil penelitian menunjukkan bahwa kebijakan pemadanan Nomor Induk Kependudukan menjadi Nomor Pokok Wajib Pajak dan keterlibatan Renjani (Relawan Pajak untuk Negeri) sangat membantu proses Ekstensifikasi. Berdasarkan data yang diperoleh dari tahun 2020-2023, kepatuhan WP OP terus meningkat dari tahun ke tahun terutama selama pelaksanaan pemberlakuan kebijakan pemadanan NIK menjadi NPWP pada tahun 2022.  Penelitian ini memberikan implikasi terhadap kebijakan dan pemberdayagunaan program Renjani guna meningkatkan kepatuhan pajak.
Kata Kunci: Ekstensifikasi Pajak; Renjani; Kepatuhan Perpajakan
Niat Gen Z Berinvestasi pada Cryptocurrency: Apakah Profitability, Awareness, dan Compatibility Berpengaruh?
Authors: Muhammad Aditiya Saputra  , Husna Salsabila  , Raissa Varahita Bahtiar  , Sativa Afriyanti  , Sekar Wulan Oktavia  , Isna Putri Rahmawati
Published: December 2024

Abstract
This study aims to examine the effect of profitability, awareness, and compatibility variables on Gen Z's intention to invest in cryptocurrency. This study used a survey method with a convenience sampling technique and obtained 141 Gen Z respondents in Surakarta City. The data was then analyzed using multiple regression analysis. The findings of this study indicate that profitability, awareness, and compatibility positively affect Gen Z's intention to invest in cryptocurrency. Understanding the Gen Z generation regarding the characteristics of cryptocurrency has an impact on the intention to invest.
Keywords: cryptocurrency; Gen Z; profitability; awareness; compatibility
Place and Scale in Sustainability Transitions
Authors: Coenen Lars , Binz Christian , Murphy James , Truffer Bernhard
Published: December 2024

In today’s world of increasing spatial inequalities, geopolitical tensions and global shifts in value chains, having a solid grasp of the spatial and multi-scalar dynamics that condition transition dynamics is of ever more importance. Initial theories of sustainability transitions have been criticized for being insufficiently equipped to assess the benefits, conflicts and unevenness that are constituted by the territorial contexts in which transitions dynamics and pathways unfold. Questions how sustainability transitions emerge across places and scales were largely off the radar. Interest and engagement with geographical dimensions of sustainability transitions grew however quickly into a prominent sub-field, characterized by a fruitful trading zone populated by geographers, transition scholars and other social scientists seeking to better account for place specificity, multi-scalarity, and spatial unevenness. This chapter outlines the contours of the Geography of Sustainability Transitions (GeoST) wider theoretical research agenda and ongoing debates, framing these specifically around conceptualizations of place and scale.
Status Quo of the Energy System and Consumption in Zambia
Authors: Chitandula Albert , Abuzayed Anas , Nyoni Kumbuso Joshua , Solà Vilalta Albert , Maliye Ruth L , Kabala Edna , Cheelo Caesar
Published: December 2024

This report offers a comprehensive overview of Zambia’s energy system, focusing on consumption trends, energy production, and the associated challenges. The first in a three-part series, it serves as the basis for understanding Zambia’s energy framework by highlighting the critical sectors that shape the nation’s energy dynamics and the broader implications for sustainable growth. Zambia’s energy system is characterised by a dependence on traditional energy sources, particularly hydropower and biomass, which has constrained the country’s ability to achieve energy security and sustainability. The urgent need for reforms to diversify energy sources, modernise infrastructure, and implement cost-reflective tariffs is evident. Addressing these issues is crucial for improving energy access and supporting Zambia’s broader development objectives.
Contributions of Gibson's Ecological Psychology to the Creation of Interactive Sound Installations
Authors: Bertarelli Gimenes Toffolo Rael
Published: December 2024

This article explores the potential contributions of Gibson's Ecological Psychology to artistic creation within the scope of Interactive Sound Installations. It provides a historical overview of the evolution of this form of art, highlighting the growing emphasis on the role of space and body (audience action) in shaping interactive art concepts. The article delves into how ecological acoustics research has integrated interdisciplinary perspectives from sociology, anthropology, and cognitive science to promote a more equitable and fair acoustic environment. Considering that the concept of the body embedded in the world is both central to interactive arts and Cognitive Science, particularly to Gibson's Ecological Psychology, this text presents its main aspects. It then discusses how these aspects can be applied in Interactive Sound Installations. In conclusion, it suggests that applying Ecological Psychology concepts to Interactive Sound Installations can contribute to the goals of recent acoustic ecology in creating a fairer acoustic environment.
Murmúrios de estorninhos como modelo para espacialização sonora
Authors: Bonduki Said , Steidle Leon
Published: December 2024

A pesquisa aqui exposta busca demonstrar a aplicabilidade de movimentos de murmurações de estorninhos como modelo para a espacialização sonora. A partir de uma transdução a ser adotada em diversos níveis, este estudo propõe a aplicação e desenvolvimento de um modelo no qual se operem controle dinâmico e perspectiva espacial a partir da abstração de murmurações e sistemas dinâmicos. Para tanto é utilizado o software Max/Msp/Jitter para implementar no meio computacional o modelo de Boids para a representação do comportamento de murmurações, que é utilizado para a espacialização sonora.
Enhancing pharmacogenomic data accessibility and drug safety with large language models: a case study with Llama3.1
Authors: Li Dan , Wu Leihong , Lin Ying-Chi , Huang Ho-Yin , Cotton Ebony , Liu Qi , Chen Ru , Huang Ruihao , Zhang Yifan , Xu Joshua
Published: December 2024

Pharmacogenomics (PGx) holds the promise of personalizing medical treatments based on individual genetic profiles, thereby enhancing drug efficacy and safety. However, the current landscape of PGx research is hindered by fragmented data sources, time-consuming manual data extraction processes, and the need for comprehensive and up-to-date information. This study aims to address these challenges by evaluating the ability of Large Language Models (LLMs), specifically Llama3.1-70B, to automate and improve the accuracy of PGx information extraction from the FDA Table of Pharmacogenomic Biomarkers in Drug Labeling (FDA PGx Biomarker table), which is well-structured with drug names, biomarkers, therapeutic area, and related labeling texts. Our primary goal was to test the feasibility of LLMs in streamlining PGx data extraction, as an alternative to traditional, labor-intensive approaches. Llama3.1-70B achieved 91.4% accuracy in identifying drug-biomarker pairs from single labeling texts and 82% from mixed texts, with over 85% consistency in aligning extracted PGx categories from FDA PGx Biomarker table and relevant scientific abstracts, demonstrating its effectiveness for PGx data extraction. By integrating data from diverse sources, including scientific abstracts, this approach can support pharmacologists, regulatory bodies, and healthcare researchers in updating PGx resources more efficiently, making critical information more accessible for applications in personalized medicine. In addition, this approach shows potential of discovering novel PGx information, particularly of underrepresented minority ethnic groups. This study highlights the ability of LLMs to enhance the efficiency and completeness of PGx research, thus laying a foundation for advancements in personalized medicine by ensuring that drug therapies are tailored to the genetic profiles of diverse populations.
Clinical and sensitization profile in peach allergy due to LTP sensitization
Authors: Gabriela Zambrano Ibarra , M. Elena Rodríguez Mazariego , Carlos López Tovar , Marta Blanco López , Ochoa M. Luisa Baeza
Published: December 2024

Background

Lipid transfer proteins (LTP) are associated with a wide range of severity of allergic reactions. However, the risk factors associated with this severity are not fully understood.

Objectives

To describe the clinical characteristics of peach-allergic patients due to LTP sensitization and analyze the relationship between the severity of the reactions and patients’ sensitization profiles.

Methods

A retrospective study of peach-allergic patients was performed. Patients were classified into LTP-monoallergic (only peach allergy) or LTP-Syndrome (peach allergy and allergy to other plants-foods related with LTP). Symptoms with Rosaceae family and other related plant foods, skin prick tests (SPTs), and IgE values were recorded.

Results

Seventy-one patients were included, 46.5% suffering from anaphylaxis, 32.3% from urticaria angioedema, and 21.2% from oral allergy syndrome. Six had monoallergy to LTP and 65 LTP syndrome. Clinical severity showed no differences according to peach SPT wheal size or Pru p 3 IgE levels. We also found no differences between the components of LTP-containing foods analyzed, the number of LTPs recognized, and the severity of symptoms. However, anaphylaxis was more frequent in patients with concomitant allergies to ≥3 groups of plant foods.

Conclusions

LTP syndrome was the most common presentation in patients with Rosaceae food allergy. The severity of the reactions was not related to peach SPT wheal size or sIgE levels to Pru p 3, but concomitant allergies to ≥3 plant food groups could be a good marker of severity.
Biotechnological progresses in modelling the human endometrium: the evolution of current in vitro techniques and emerging trends
Authors: Agustina-Hernández Marcos , Francés-Herrero Emilio , Gómez-Álvarez María , Alonso-Frías Paula , Romeu Mónica , Monzó Ana , Ferrero Hortensia , Bueno-Fernandez Clara , Cervelló Irene
Published: December 2024

The endometrium plays a fundamental role in the reproductive system yet many etiologies of infertility-related endometrial diseases such as endometriosis, adenomyosis, Asherman’s syndrome or endometrial cancer remain unknown. There are currently no treatments that minimize the effects of this devastating disorder. Appropriate model systems that closely mimic the architecture and function of the endometrium in healthy and pathological states are needed to understand the underlying molecular pathways and develop novel or more effective treatments. This review summarizes the key milestones of in vitro culture models of the human endometrium throughout history, as well as the applications of advanced bioengineering techniques in the modelling of both healthy and pathological endometrium. Opportunities for future approaches are also discussed.
The efficacy of a nitric oxide-releasing formulation on nares isolated Methicillin-Resistant Staphylococcus aureus in porcine wound infection model
Authors: Davis Stephen C. , Gil Joel , Solis Michael , Strong Ryan
Published: December 2024

Background

The colonization of Staphylococcus aureus (SA) acquired in nosocomial infections may develop acute and chronic infections such as Methicillin-Resistant Staphylococcus aureus (MRSA) in the nose. As a commensal microorganism with the ability to form a biofilm, SA can dwell on the skin, nostrils, throat, perineum, and axillae of healthy humans. Nitric oxide (NO) is an unstable gas with various molecular functions and has antimicrobial properties which are converted into many potential treatments.

Methods

Methicillin-Resistant Staphylococcus aureus MRSA BAA1686 isolated from nasal infection was used in a porcine wound infection model. Deep partial-thickness wounds (10mm x 7mm x 0.5mm) were made on three animals using a specialized electrokeratome. All wounds were inoculated and then covered with polyurethane film dressings for biofilm formation. After 48 hours, three wounds were recovered from each animal for baseline enumeration. The remaining wounds were randomly assigned to six treatment groups and treated once daily. The treatment groups are as follows: NO topical ointments concentrations of 0.3, 0.9 and 1.8%, Vehicle Ointment, Mupirocin 2%, and Untreated Control. Microbiological recoveries were conducted on day 4 and day 7.

Results

The greatest efficacy observed from the NO formulations against MRSA BAA1686 was the 1.8% concentration. This agent was able to reduce more than 99% of bacterial counts when compared to Baseline, Vehicle Ointment, and Untreated Control wounds on both assessment days. Mupirocin 2% was the overall best treatment against MRSA BAA1686 on both assessment days, with a significant reduction (p ≤ 0.05) of 4.70 ± 0.13 Log CFU/mL from day 4 to day 7.

Conclusions

Overall, the positive control Mupirocin 2% was the most effective in eliminating MRSA BAA1686 throughout the study. This experiment demonstrated a downward trend from the highest concentration of NO topical ointment formulations to the lowest concentrations on both assessment days (0.3% - 1.8%). Out of all NO topical ointments, the highest concentration (1.8%) was the most effective with the potential to be an alternative treatment against a MRSA nasal strain biofilm.
Linking habitat and population viability analysis models to account for vegetation dynamics, habitat fragmentation, and social behavior of a metapopulation of Florida scrub-jays
Authors: Lacy Robert C. , Breininger David R. , Breininger Daniel J. , Savage Anna E. , Forsman Anna M. , Hoffman Eric A. , McGuffey Stephen D. , DeMeyer David , Mecklenborg Todd
Published: December 2024

Population dynamics and viability are driven by interactions among habitat and species biology. The Florida scrub-jay (Aphelocoma coerulescens) is a declining and Federally Threatened bird species that requires mid-succession habitat of partly open soil surface with mid-height vegetation. This habitat is created and sustained in a dynamic state of vegetation growth and periodic natural (e.g., fire) or managed (e.g., mechanical clearing) disturbances. Florida scrub-jays once occupied open oak scrub habitats across much of peninsular Florida but have been reduced to a few regional metapopulations and scattered isolated remnant populations. Many of these populations are undergoing continuing decline as open scrub is either converted to residential development or transitions into closed pine and oak forests due to fire suppression. Long-term field studies have shown that breeding and survival rates are determined by the quality of the scrub habitat, with the demography influenced by and in turn mediating the social structure. Prior Population Viability Analyses (PVA) that included dependencies of demographic rates on habitat and social structure indicated that the east coast Florida metapopulations were fragmented into remnant protected patches that were too small and isolated to support long-term persistence, even if the remaining habitat area and quality was sustained. Moreover, recent modeling of habitat transitions under various proposed management schemes, in conjunction with implementation of Adaptive Resource Management (ARM), projected that the proportion of optimal habitat will continue to decline. In this study, we integrated these habitat projections within the PVA and found that the Brevard County mainland metapopulation is projected to decline toward extinction unless habitat quality, extent, and connectivity can be improved. Land managers have recently implemented new innovative methods for restoring optimal scrub habitat, identifying potential improvements in habitat connectivity of nearby populations, and translocation methods to increase and reinforce the demographic and genetic integrity of local populations. Our linked habitat-population models project that the combination of such habitat and population management actions can stabilize the metapopulation and achieve long-term viability.
Anatomy of the aortic segmental arteries—the fundamentals of preventing spinal cord ischemia in aortic aneurysm repair
Authors: Pruidze Paata , Weninger Jeremias T. , Didava Giorgi , Schwendt Karoline M. , Geyer Stefan H. , Neumayer Christoph , Nanobachvili Josif , Eilenberg Wolf , Czerny Martin , Weninger Wolfgang J.
Published: December 2024

Objective

Spinal cord ischemia due to damage or occlusion of the orifices of aortic segmental arteries (ASA) is a serious complication of open and endovascular aortic repair. Our study aims to provide detailed descriptions of the proximal course of the ASAs and metric information on their origins.

Materials and methods

Initially, 200 randomly selected, embalmed cadavers of human body donors were anatomically dissected and systematically examined. On macroscopic inspection, 47 showed severe pathologies and were excluded. Of the remaining 153, 73 were males and 80 females.

Results

In total, 69.9% of the aortae showed 26–28 ASA orifices. In 59.5% the most proximal ASA, at least unilaterally, was the third posterior intercostal artery, which originated from the descending aorta at approximately 10% of its length. In 56.2%, the left and right ASAs had a common origin in at least one body segment. This mainly affected the abdominal aorta and L4 in particular (54.2%). The ASAs of lumber segments 1–3 originated strictly segmentally. In contrast, in 80.4%, at least one posterior intercostal artery originated from a cranially or caudally located ipsilateral ASA. Such an arrangement was seen along the entire thoracic aorta. Further descriptions of variants and metric data on ASA orifices are presented.

Conclusion

Our large-scale study presents a detailed topographic map of ASAs. It underscores the value of preoperative CT councils and provides crucial information for interpreting the results. Furthermore, it aids in planning and conducting safe aortic intervention and assists in deciding on single- or two-staged stent graft procedures.
Summary of Keynote Speeches from the 2024 Voice AI Symposium, presented by the Bridge2AI-Voice Consortium
Authors: Patel Rupal , Price Nicholson , Bahr Ruth , Bedrick Steven , Bensoussan Yael , Bélisle-Pipon Jean-Christophe , Dorr David , Jackson Christie , Krussel Andrea , Salvi Cruz Samantha , Toghranegar Jamie , Watts Stephanie , Zhao Robin ,   The Bridge2AI-Voice Consortium, Powell Maria
Published: December 2024

Introduction

The 2024 Voice AI Symposium, hosted by the Bridge2AI-Voice Consortium in Tampa, FL, featured two keynote speeches that addressed the intersection of voice AI, healthcare, ethics, and law. Dr. Rupal Patel and Dr. Nicholson Price provided insights into the advancements, applications, and challenges of AI-driven voice tools in healthcare. The symposium aimed to advance cross-disciplinary collaboration and establish frameworks for the ethical use of AI technologies in healthcare.

Methods

The keynote speeches, delivered on May 1st and 2nd, were 30 minutes each, followed by 10-minutes Q&A sessions. The audio was recorded and transcribed using Whisper (v7.13.1). Content summaries were generated with the aid of ChatGPT (v4.0), and the authors reviewed and edited the final transcripts to ensure accuracy and clarity.

Results

Dr. Rupal Patel’s keynote, “Reflections and New Frontiers in Voice AI”, explored the potential of voice AI for early detection of health conditions, monitoring disease progression, and promoting non-invasive global health management. She highlighted innovative uses beyond traditional applications, such as examining menopause-related symptoms. Dr. Nicholson Price’s keynote, “Governance for Clinical Voice AI”, addressed the regulatory and ethical challenges posed by AI in healthcare. He stressed the need for context-aware systems and dynamic legal frameworks to address liability and accountability.

Conclusions

The 2024 Voice AI Symposium highlighted the transformative potential of voice AI for early detection, health monitoring, and reducing healthcare disparities. It also underscored the importance of dynamic governance to address the ethical and regulatory challenges of deploying AI in clinical settings.
The role of exosomes in the pathogenesis and management of diabetic kidney disease: a systematic review and meta-analysis
Authors: Zheng Yan , Xu Chu , Jin Yan
Published: December 2024

Objective

This systematic review and meta-analysis aimed to synthesize the role of exosomes in the pathogenesis and management of diabetic kidney disease.

Methods

PubMed, Embase, Cochrane Library, and Web of Science were searched for studies that compared the levels of exosomes between patients with diabetic kidney disease and controls published up to 27 November 2023. Methodological quality was assessed using the JBI Appraisal Checklist for Case–Control Studies. The methodology of the samples and the main results were summarized. A meta-analysis of the diagnostic performance of exosomes was performed using estimates of test sensitivity and specificity, and these values were summarized using summary receiver-operating characteristic curves. The results were reported following the PRISMA 2020 checklist.

Results

A total of 32 studies, including 1,119 patients with diabetic kidney disease and 1,328 controls, met the inclusion criteria. A total of 78 upregulated and 22 downregulated microRNAs, 2 upregulated and 4 downregulated mRNAs, 6 upregulated and 1 downregulated proteins, and 4 upregulated lipids were identified. The miR-126, miR-145, miR-150, miR-21, and WT1 mRNA dysregulation were consistently reported in at least two studies. The overall sensitivity and specificity of the exosomes in diabetic kidney disease diagnosis were 0.70 (95% CI: 0.59–0.80) and 0.79 (95% CI: 0.70–0.85), respectively. The summary receiver operating characteristic curve was plotted to assess diagnostic accuracy with the area under the curve (AUC) of 0.82 (95% CI: 0.78–0.85).

Conclusion

Exosomes have great potential to become effective diagnostic biomarkers for diabetic kidney disease. Panels of exosomes or the combination of exosomes with other clinical indicators seemed more accurate than single exosomes.
Exposure to air pollution and the risk of type II diabetes mellitus: a time-series study
Authors: Hou Zhuomin , Wang Yongbin , Chen Zhigang , Sun Siyu , Xie Na , Chen Yingen , Wang Lujie , Lin Fei , Zhao Guoan
Published: December 2024

Background

Environmental factors have been identified as primary risk factors for type 2 diabetes mellitus (T2DM). However, studies on the association between environmental factors and T2DM have mainly focused on morbidity and mortality, which do not fully reflect the disease burden stemming from air pollution. Therefore, we aimed to evaluate the correlation between air pollution and T2DM, including hospital length of stay (LOS) and costs.

Methods

We collected data on patients with T2DM from three healthcare institutions in Xinxiang from 2016–2021. Data on particulate and gaseous pollutants in Xinxiang and daily meteorological data were collected from national databases. The distribution lag nonlinear model was used to evaluate the correlation between air pollution and the number of inpatients with T2DM, LOS, and hospital costs. Subgroup analyses were conducted to identify potential modifying factors.

Results

Overall, 13,797 patients with T2DM were included in our analysis. Within the cumulative lag of 7 days, with every increase of 1 mg/m3 of carbon monoxide (CO) and 10 μg/m3 of 2.5 microns particulate matter, nitrogen dioxide and ozone exhibited significant associations with an increase in diabetes hospitalization risk. CO exhibited adverse effects on LOS on most lag days. Moreover, hospital costs were significantly associated with the attributable fraction of LOS and hospital costs attributed to diabetes.

Conclusions

Exposure to air pollutants increased T2DM risk, imposing significant economic and social burdens in Xinxiang, China. Implementing policies to reduce air pollutant exposure may decrease T2DM admissions, costs, and LOS.
Optimal configuration strategy of energy storage for enhancing the comprehensive resilience and power quality of distribution networks
Authors: Liu Zhihong , Wang Bingqiang , Chen Yunyao , Chen Yuzhou , Jiayang Lamu , Zhang Qingyuan , Yuan Ningting , Lu Qing , Zhu Liuyong , Lin Yujie
Published: December 2024

Resilience assessment and enhancement in distribution networks primarily focus on the ability to support and recover critical loads after extreme events. With the increasing integration of new energy sources and power electronics, distribution networks have gained a degree of resilience. However, the impact of power quality issues on these networks has become more severe. In some cases, even networks assessed as highly resilient by users suffer equipment damage and substantial economic losses due to power quality issues. To address this issue, this paper builds upon conventional distribution network resilience assessment methods by supplementing and modifying indices in the dimensions of resistance and recovery to account for power quality issues. Furthermore, an optimized energy storage system (ESS) configuration model is proposed as a technical means to minimize the total operational cost of the distribution network while enhancing comprehensive resilience indices. The proposed nonlinear optimization model is solved using second-order cone relaxation techniques. Finally, the proposed strategy is simulated on the IEEE 33-node distribution network. The simulation results demonstrate that the proposed strategy effectively improves the comprehensive resilience indices of the distribution network and reduces the total operational cost.