bluuebunny/crossref_metadata_2025 huggingface dataset:
Big Data− Análisis informétrico de documentos indexados en Scopus y Web of Science
Authors: Martínez Musiño Celso
Published: January 2020

El fenómeno Big Data es reciente, como lo demuestran las escasas publicaciones sobre el tema, lo cual incentiva esta investigación cuyos objetivos son compilar y referenciar documentos académicos incluidos en las bases de datos Scopus y Web of Science y analizar los contenidos. El método empleado es la investigación descriptiva, de primera aproximación, que consistió en la búsqueda y recuperación de información en Scopus y Web of Science en el periodo 2008-2018. Se analizaron 39 documentos, los cuales corresponden a 70 autores distribuidos en 14 títulos de revistas científicas, cuyo tipo de contribución se distribuye en 19 artículos, 10 comentarios, seis cartas al editor y cuatro reseñas. Otro de los resultados relevantes es que hay una alta concentración de publicaciones en Science y Nature. Los fenómenos Big Data y la CI son de reciente cuño y se encuentran en redefiniciones y conformaciones de dominios de estudios constantes. Encontramos un interés por las investigaciones Big Data; por otra parte, después de un análisis conceptual, proponemos una definición de Big Data.
Cucurbitacins and its Anticancer property: A Review
Authors: Samuel Ashmi
Published: January 2020

Cucurbitacins which are structurally unlike triterpenes found in the members of Cucurbitaceae and several other plant families possess immense pharmacological activity. This diverse group of compounds may substantiate to be important lead molecules for the treatment of cancer. Research focused on this unattended medicinal compound can prove the significance and explore the hidden potential to cure various diseases. These compounds show their proposed mode of action, probable molecular targets and have future aspects of their use as a medicinal agent. This review is aimed to provide the chemical nature and medicinal property of cucurbitacins.
Crédito para la frontera. Negociación institucional, coerción militar y financiación de la Real Hacienda en el Río de la Plata borbónico (1767-1777)
Authors: Wasserman Martín Leandro Ezequiel
Published: January 2020

La guerra de los Siete Años (1754-1763) demostró a la Corona española la urgencia de fortalecer la defensa en territorios estratégicos. La tensión entre España y Portugal condujo al gobierno borbónico a robustecer los recursos para la defensa de sus dominios en el Río de la Plata y a implementar reconfiguraciones institucionales concordantes. En ese proceso, una multitud de deudas con actores locales y regionales permitió a la Real Hacienda en Buenos Aires sostener el aparato defensivo. Si actores comerciales locales encontraban en dicho financiamiento un campo lucrativo, incrementar recursos fiscales con fines militares era un punto de confluencia entre los objetivos de la Corona, la reconfiguración institucional y los intereses de acreedores locales. Así, la mediación de actores locales en el funcionamiento del erario pervivía durante el proceso de centralización institucional borbónica.
Arquitectura religiosa en la Nueva Granada. La catedral de Santa Marta durante el siglo XVIII
Authors: Gámez Casado Manuel
Published: January 2020

El texto que se presenta tiene como objetivo analizar el proceso constructivo de la catedral de Santa Marta durante el siglo XVIII. Si bien se plantearán una serie de antecedentes necesarios para clarificar lo ocurrido en las primeras décadas de aquel siglo, la intervención de arquitectos e ingenieros militares a fines de este permitió concluir el principal edificio religioso de la ciudad. Para clarificar su importancia en el contexto del Nuevo Reino de Granada, partiendo de distintas publicaciones y aportando fuentes primarias, se publicarán nuevos datos y se analizarán distintos planos que contribuirán al conocimiento del edificio.
Visitar y cuantificar: la población de la real cárcel de corte de Santafé según los libros de visita (1776-1783)
Authors: Ariza Martínez Juan Sebastián
Published: January 2020

Durante el periodo colonial la cárcel fue entendida como un espacio de control utilizado por las autoridades para “limpiar” la sociedad de personas que a partir de su accionar alteraban el ordenamiento social. Los corpus legales utilizados por las autoridades coloniales establecían que toda ciudad de las Américas debía tener un espacio que fuera destinado para la custodia y guarda de los criminales; y Santafé, como capital virreinal del Nuevo Reino de Granada, contó con tres cárceles, además de cuarteles, hospitales y conventos que funcionaron como lugares de retención. Dentro de la cárcel de corte de Santafé, objeto de estudio de las siguientes líneas, se practicaron varias visitas institucionales con el fin de garantizar su correcto funcionamiento. A partir de ellas, se busca indagar acerca del funcionamiento de la cárcel, la población que en ella estaba recluida y el tipo de crímenes que se cometieron en la ciudad entre 1772 y 1800, con el fin de conocer la importancia de esta institución dentro de Santafé.
Cognitive pathways in small businesses decision-making processes
Authors: Rizza Carmela
Published: January 2020

Research on small firms decision-making processes has stimulated accounting scholars to investigate how peculiarities of these firms could affect the way how they are managed, focusing on the limited diffusion of managerial accounting practices in these contexts. Controversial results on how managerial accounting practices work in small firms, claim for further research that mostly focus on how managerial accounting systems work in the decision-making processes of small firms. In this view, adopting a sociological perspective managerial accounting practices are interpreted as tools for making sense of past decisions and to discover future alternatives through cognitive pathways. Thus, the attention is on learning processes activated through balance sheet analysis in a small firm that was implementing this tool. The main contribution of this paper concerns the crucial role that balance sheet analyses play in supporting the organizational actors to monitor the state of the company and the decision-making processes. The discussion of balance sheet analyses results enabled the owner and his staff to appraise the current situation and pinpoint weaknesses, allowing them to analyse past events with a new lens and activating new knowledge pathways. Case evidence supports theoretical contributions to the decision-making processes of small businesses helping to better understand how managerial accounting practices work to discover future alternatives through cognitive pathways. The paper provides also a practical contribution concerning the crucial role that balance sheet analyses play in small firms.
Diagnóstico prenatal de anomalías cromosómicas
Authors: Alegre G. , Anderlini C. , Sadir M. , Stehli C. , Cuestas E.
Published: January 2020

INTRODUCCION: Las anomalías cromosómicas son alteraciones en los cromosomas sexuales o de los autosomas que pueden ser estructurales o numéricas. El Síndrome de Down o trisomía 21 es una de las anomalías cromosómicas más frecuentes, donde el 95% de las afecciones se deben a una trisomía completa. Estas alteraciones generan un importante aumento de la morbimortalidad, por lo cual es importante conocer factores de riesgo y sospecharlas prenatalmente. Los métodos más utilizados para el screening prenatal de estas anomalías son los marcadores serológicos y las pruebas de imágenes ecográficas. Otras pruebas de diagnóstico prenatal no invasivas que se pueden utilizar se basan en la detección ADN fetal que circula libremente en plasma materno. METODOLOGÍA: A partir de un escenario clínico se planteó una pregunta clínica estructurada. Se realizó una búsqueda bibliográfica en Pubmed con el objetivo de encontrar un artículo que pueda responder a nuestro interrogante sobre si el estudio del ADN fetal circulante en comparación con el screening combinado es un método diagnóstico más sensible y específico para puede detectar el Síndrome de Down. Se seleccionó el siguiente artículo: “Cell-free DNA Analysis for Noninvasive Examination of Trisomy”. ANALISIS DEL ARTICULO: Para poder responder a nuestra pregunta clínica estructurada, se realizó un análisis secundario de los datos de las distintas variables calculando los valores de sensibilidad (S), especificidad (E), valor predictivo positivo (VPP), valor predictivo negativo (VPN) y su respectivo intervalo de confianza del 95% (IC 95%). Destacamos también el resultado del área bajo la curva (ABC) de la curva ROC (Receiver Operating Characteristic). CONCLUSIÓN: el screening con ADN fetal presenta una mayor sensibilidad y especificidad frente al screening combinado (ecografía y pruebas bioquímicas) para el diagnóstico del Síndrome de Down. Pero su elevado costo implica aún un limitante a resolver
Performance characteristics and mechanical resistance of a hot mix asphalt using gilsonite and blast furnace slag
Authors: Rondon-Quintana H. , Zafra-Majia C. , Chaves-Pabon S.
Published: January 2020

Replacing natural aggregates (NA) for blast furnace slag (BFS) is seen as a technique that is beneficial for the environment. Additionally, in high temperature climates, rigidizing the asphalt by employing gilsonites (G) could be an alternative in order to increase rutting resistance. This study substituted in volume, part of the coarse fraction of NA for BFS in a hot mix asphalt (HMA) that employed asphalt modified with G in wet process. Physical properties of BFS are presented, as well as its chemical and mineral compositions. Additionally, physical properties of asphalt modifi ed are shown. In regards to HMAs, their resistance under monotonic load (Marshall test and indirect tensile strength test), cyclic (resilient modulus, permanent deformation and fatigue) and moisture damage (tensile strength ratio – TSR) was evaluated. All HMAs were manufactured employing the same asphalt content from the control mix. An ANOVA variance analysis was conducted. Based on ANOVA, when the NA volume is substituted with BFS, Marshall stability/ /flow relation significantly drops. However, when such substitution is carried out using G-modified asphalt, resistance under monotonic load, stiffness under cyclic load, resistance to permanent deformation and moisture damage notably increase. Fatigue resistance also increases but such increase is not statistically significant.
First natural frequency of multi-segment floor joists with variable cross section
Authors: Chalecki M. , Jaworski J. , Szlachetka O.
Published: January 2020

The Rayleigh’s method can be used to determine the first natural frequency of beams with variable cross-section. The authors analyse multi-segment simply supported beams, symmetrical with respect to their midpoint, having a constant width and variable height. The beams consist generally of five segments. It has been assumed that the neutral bar axis deflected during vibrations has a shape of a beam deflected by a static uniform load. The calculations were made in Mathematica environment and their results are very close to those obtained with FEM.
A review of green roof incentives as motivators for the expansion of green infrastructure in European cities
Authors: Burszta-Adamiak E. , Fialkiewicz W.
Published: January 2020

Nowadays green roofs play a key role in alleviating the negative effects of urbanization. Despite investors awareness of the advantages of green roofs, there are still some barriers that hinder investments on a large scale. As a result a financial and non-financial incentives are implemented. The review presented in this paper allowed to identify the most popular initiatives and to formulate recommendations for creating incentive supporting implementation of green roofs in urban areas.
From the heap to the park - reclamation and adaptation of degraded urban areas for recreational functions in Poland
Authors: Lukaszewicz J. , Fortuna-Antoszkiewicz B. , Dlugonski A. , Wisniewski P.
Published: January 2020

The article covers the issue of land reclamation of two degraded urban areas: Silesia Park (Chorzów city, Southern Poland) and Górka Rogowska Park (Łódź city, Central Poland). The research raises the subject of vegetation condition, plant succession, and the usage of a given area in terms of recreational functions. The first example of Silesia Park (case study 1) indicates a successful nature and landscape reclamation. The intention of park’s designers was to create a permanent and self-regulating natural system in accordance with the principle that the wider the area of the park and the longer it exists, the more it is ecologically sustainable and the more it affects its surroundings. The second example of Górka Rogowska Park (case study 2) shows that despite numerous sensible design ideas for satisfactory development, the area has not been properly reclaimed. In this location, the conducted works have degraded landscape values and recreational opportunities. Nevertheless, the research showed that this park is an area with high natural potential, and with properly designed decisions and contribution of city’ authorities might become a popular year-round and multi-functional public space offering a various range of recreational activities similar to the Silesia Park. The research led to the conclusion that constant monitoring is necessary to counteract the negative effects of the anthropopression through appropriate care (plant control, elimination of invasive plants) and design (rational development of leisure activities of a given place) decisions on reclaimed urban areas.
Green infrastructure as a disease prevention and rehabilitation tool
Authors: Dmochowski T.
Published: January 2020

This article tackles with the problem of preventing diseases caused by physical inactivity. It offers a brief review of deadliest diseases and defi nes critical role of green public spaces in their prevention. Article presents patient treatment costs, in contrast to the costs of organizing green public spaces, suggesting substantial relief from economic burden sustained by national health fund by offering green public spaces designed specifi cally for disease prevention instead of conventional treatment.
First-principles and CALPHAD-type study of the Ir-Mo and Ir-W systems
Authors: Huang Y.-Y. , Wu B. , Li F. , Chen L.-L. , Deng Z.-X. , Chang K.
Published: January 2020

This study presents the thermodynamic modeling of the Ir-Mo and Ir-W systems by means of the CALPHAD (CALculation of PHAse Diagrams) approach supported with the first-principles calculations. A critical evaluation of the phase equilibria and the thermodynamic property data in literature was conducted for both systems. Due to the lack of experimental data, the first-principles calculations were applied to obtain the enthalpies of the solid and intermetallic phases. The thermodynamic parameters were assessed using the PARROT module of Thermo-Calc. A set of self-consistent parameters for the Ir-Mo and Ir-W systems was obtained after the optimization. Satisfactory agreement between the calculated results and the experimental data, including phase equilibria and thermodynamic properties was achieved.
Toxicity of plant essential oils to Cryphonectria parasitica (Murr.) barr, the causal agent of chestnut blight
Authors: Lukovic Jelena , Potocnik Ivana , Rekanovic Emil , Milijasevic-Marcic Svetlana , Todorovic Biljana , Kostic Miroslav , Radulovic Zlatan
Published: January 2020

Twenty-two essential oil samples from Germany and Albania were assayed to
test their inhibitory and fungicidal activity against Cryphonectria
parasitica (Murr.) Barr., the major causal agent of chestnut blight on
chestnut trees, using the fumigant macrodilution method. Test concentrations
of the oils in air phase were: 0.02, 0.04, 0.08, 0.16 and 0.32 ?l ml-1, and
minimum inhibitory and fungicidal concentrations were determined. The
strongest activity was shown by two samples of mint oil from Germany and
Albania, and black pine at the concentration of 0.02 ?l ml-1 of air for both
test isolates (M1 and 4S). The tested plant essential oils also included:
eucalyptus, sage, silver fir and cade. Only three samples of EOs (mint (2)
and black pine) were lethal to both isolates. Sage and silver fir oils were
more toxic to the M1 isolate, while cade and eucalyptus oils were more toxic
to the 4S isolate. Fifteen oils: mint (2), black pine, cade, eucalyptus,
silver fir, sage, pine (4), oregano, lavender, and rosemary (2), inhibited
the growth of Cryphonectria parasitica, and seven oils (two samples of mint,
eucaliptus, black pine, sage, silver fir and cade) showed fungicidal effects
on the pathogen.
Deconstruction of ‘scientifically based injustices’: About post-war traumatized populations of ‘spoilers’ in Croatia
Authors: Cvikic Sandra
Published: January 2020

Contemporary Croatian social reality's determined by the epistemological and
policy frameworks developed to understand and care for the post-war Yugoslav
?traumatized citizens.? Knowledge produced in that respect exerts powerful
influence on citizen?s lives thus subjecting them to detrimental effects of
scientifically designed conceptual frameworks and discursive practices of
conducted research (Hass, 2001). So far, researched ?transitional life? in
post-communist/postwar Croatia is rooted in ?knowledge power structures?
meticulously developed inside transitional justice academic and policy works
on former Yugoslav societies enabling continuous production of
?scientifically based injustices? (De Genova et al, 2016). Therefore, the
main objective in this paper is to examine knowledge production about
Croatian ?transitional society? and ?traumatized populations? and how its
discursive construction of the new ?Other? - ?spoilers? (Fisher, 2011) is
scientifically rooted in ?transitional justice? policy application (Leebaw,
2005).Thereby, a selection of transitional justice scholarly works on Croatia
and the Western Balkans along with documents produced by the international
organizations/institutions in the period 1997-2017 are studied. Foucauldian
discourse analysis (Klos-Czerowinska, 2015) coupled with his (2003, 2007) and
Agamben?s (1998, 2005) understanding of the postmodern European society are
used to ?deconstruct? (Janks, 2005) ?scientifically based injustices?
produced about post-war traumatized populations of ?spoilers? in Croatia.
PI3Kδ as a Novel Therapeutic Target in Pathological Angiogenesis
Authors: Wu Wenyi , Zhou Guohong , Han Haote , Huang Xionggao , Jiang Heng , Mukai Shizuo , Kazlauskas Andrius , Cui Jing , Matsubara Joanne Aiko , Vanhaesebroeck Bart , Xia Xiaobo , Wang Jiantao , Lei Hetian
Published: January 2020

Diabetic retinopathy is the most common microvascular complication of diabetes, and in the advanced diabetic retinopathy appear vitreal fibrovascular membranes that consist of a variety of cells, including vascular endothelial cells (ECs). New therapeutic approaches for this diabetic complication are urgently needed. Here, we report that in cultured human retinal microvascular ECs, high glucose induced expression of p110δ, which was also expressed in ECs of fibrovascular membranes from patients with diabetes. This catalytic subunit of a receptor-regulated PI3K isoform δ is known to be highly enriched in leukocytes. Using genetic and pharmacological approaches, we show that p110δ activity in cultured ECs controls Akt activation, cell proliferation, migration, and tube formation induced by vascular endothelial growth factor, basic fibroblast growth factor, and epidermal growth factor. Using a mouse model of oxygen-induced retinopathy, p110δ inactivation was found to attenuate pathological retinal angiogenesis. p110δ inhibitors have been approved for use in human B-cell malignancies. Our data suggest that antagonizing p110δ constitutes a previously unappreciated therapeutic opportunity for diabetic retinopathy.
Bariatric Surgery Rapidly Decreases Cardiac Dietary Fatty Acid Partitioning and Hepatic Insulin Resistance Through Increased Intra-abdominal Adipose Tissue Storage and Reduced Spillover in Type 2 Diabetes
Authors: Carreau Anne-Marie , Noll Christophe , Blondin Denis P. , Frisch Frédérique , Nadeau Mélanie , Pelletier Mélissa , Phoenix Serge , Cunnane Stephen C. , Guérin Brigitte , Turcotte Eric E. , Lebel Stéfane , Biertho Laurent , Tchernof André , Carpentier André C.
Published: January 2020

Reduced storage of dietary fatty acids (DFAs) in abdominal adipose tissues with enhanced cardiac partitioning has been shown in subjects with type 2 diabetes (T2D) and prediabetes. We measured DFA metabolism and organ partitioning using positron emission tomography with oral and intravenous long-chain fatty acid and glucose tracers during a standard liquid meal in 12 obese subjects with T2D before and 8–12 days after bariatric surgery (sleeve gastrectomy or sleeve gastrectomy and biliopancreatic diversion with duodenal switch). Bariatric surgery reduced cardiac DFA uptake from a median (standard uptake value [SUV]) 1.75 (interquartile range 1.39–2.57) before to 1.09 (1.04–1.53) after surgery (P = 0.01) and systemic DFA spillover from 56.7 mmol before to 24.7 mmol over 6 h after meal intake after surgery (P = 0.01), with a significant increase in intra-abdominal adipose tissue DFA uptake from 0.15 (0.04–0.31] before to 0.49 (0.20–0.59) SUV after surgery (P = 0.008). Hepatic insulin resistance was significantly reduced in close association with increased DFA storage in intra-abdominal adipose tissues (r = −0.79, P = 0.05) and reduced DFA spillover (r = 0.76, P = 0.01). We conclude that bariatric surgery in subjects with T2D rapidly reduces cardiac DFA partitioning and hepatic insulin resistance at least in part through increased intra-abdominal DFA storage and reduced spillover.
Plasma N-Glycans as Emerging Biomarkers of Cardiometabolic Risk: A Prospective Investigation in the EPIC-Potsdam Cohort Study
Authors: Wittenbecher Clemens , Štambuk Tamara , Kuxhaus Olga , Rudman Najda , Vučković Frano , Štambuk Jerko , Schiborn Catarina , Rahelić Dario , Dietrich Stefan , Gornik Olga , Perola Markus , Boeing Heiner , Schulze Matthias B. , Lauc Gordan
Published: January 2020

OBJECTIVE

Plasma protein N-glycan profiling integrates information on enzymatic protein glycosylation, which is a highly controlled ubiquitous posttranslational modification. Here we investigate the ability of the plasma N-glycome to predict incidence of type 2 diabetes and cardiovascular diseases (CVDs; i.e., myocardial infarction and stroke).

RESEARCH DESIGN AND METHODS

Based on the prospective European Prospective Investigation of Cancer (EPIC)-Potsdam cohort (n = 27,548), we constructed case-cohorts including a random subsample of 2,500 participants and all physician-verified incident cases of type 2 diabetes (n = 820; median follow-up time 6.5 years) and CVD (n = 508; median follow-up time 8.2 years). Information on the relative abundance of 39 N-glycan groups in baseline plasma samples was generated by chromatographic profiling. We selected predictive N-glycans for type 2 diabetes and CVD separately, based on cross-validated machine learning, nonlinear model building, and construction of weighted prediction scores. This workflow for CVD was applied separately in men and women.

RESULTS

The N-glycan–based type 2 diabetes score was strongly predictive for diabetes risk in an internal validation cohort (weighted C-index 0.83, 95% CI 0.78–0.88), and this finding was externally validated in the Finland Cardiovascular Risk Study (FINRISK) cohort. N-glycans were moderately predictive for CVD incidence (weighted C-indices 0.66, 95% CI 0.60–0.72, for men; 0.64, 95% CI 0.55–0.73, for women). Information on the selected N-glycans improved the accuracy of established and clinically applied risk prediction scores for type 2 diabetes and CVD.

CONCLUSIONS

Selected N-glycans improve type 2 diabetes and CVD prediction beyond established risk markers. Plasma protein N-glycan profiling may thus be useful for risk stratification in the context of precisely targeted primary prevention of cardiometabolic diseases.
The Spatial Planning of Sustainable Transportation: Study Case of Semarang City
Authors: Nihayah Dyah Maya , Nurfitrokha Yunilia
Published: January 2020

As capital of Central Java, Semarang City has high accessibility since it has harbor, airport, and as the main lane of the mobility. The common urban issues felt by the community are traffic, air pollution, and the lack of public facilities for the non-motorize such as pedestrian track. It is necessary for urban managers and planners to conduct necessary planning and analysis for the development of urban transportation system through a strategic perspective. The objective of this article is to determine the process of spatial planning prioritized to achieve a sustainable transportation in Semarang City. This research was qualitative descriptive. Data were analyzed using the Analysis Hierarchy Process Method. The result showed that the planning of sustainable spatial transportation in Semarang City was arranged by some criteria in its planning; economic aspect, environment and the third is social aspect. The planning of sustainable transportation can be done by providing mode of reliable and well integrated mass transportation, the determining of policy of one RTH for one sub-district and providing a City Walk (a free vehicle area) so that the a friendly non-motorize city concept could be created
Opportunities and Challenges of Jointly Building of the Polar Silk Road: China’s Perspective
Authors: Jian Yang , Long Zhao
Published: January 2020

Dramatic changes, mainly caused by global warming and globalization in recent decades, have been evident in the Arctic. The peace and stability of the Arctic, scientific research in the region, potential business opportunities and international governance have sparked widespread attention and debates around the globe. The joint establishment of the Polar Silk Road (PSR) is tantamount to international cooperation initiative between Russia, China and the related Arctic countries, which is intended to achieve common development and joint governance of the Arctic through knowledge accumulation, helps to promote interconnectivity and sustainable development in the region. As a part of China’s Arctic policy and cooperation between Eurasian Economic Union (EAEU) and the Belt and Road Initiative (BRI), China focuses on the coordination of national interests and strategies of relevant states regarding development of Arctic sea routes and infrastructure, prioritizes knowledge accumulation and scientific research as the guiding principle for cooperation, promotes green technology solutions and humanistic concerns, and recognizes the PSR cooperation as a new growth pole for China-Russia pragmatic cooperation. However, due to fragile natural environment and political, economic and social sensitivities of the Arctic, significant interference of global and regional geopolitics, potential challenges of global environmental politics, Acknowledgement and capacity gaps between participants, economic and technological uncertainties are major challenges for feasibility and efficiency of cooperation, requiring more in-depth scientific research, comprehensive assessments and regular coordination and communication between all stakeholders.
Arctic Port State Control as a Tool of Enforcement of the Polar Code
Authors: Todorov A. A.
Published: January 2020

Intensification of Arctic shipping requires the regional states to take appropriate measures aimed at mitigation of emerging risks. This relates to ensuring the compliance by vessels with the relevant provisions of international law in the field of safety of navigation and protection of the marine environment. The Polar code, which entered into force in 2017, set the minimum safety and environmental standards for the vessels navigating in the severe waters of the Arctic and the Antarctic. However, under the Code the responsibilty for ensuring compliance with the requirements rests with the administration of the flag state. In general, this reflects the approach of the international law, according to which the flag state is fully responsible for ensuring that a vessel under its flag meets international standards. Nevertheless, polar shipping represents a special kind of activities, which requires special experience and skills, including of the flag state administration carrying out the control. The problem is aggravated by the fact that vessels navigate in the Arctic waters often under a flag of convinience, with states not being able to perform a proper control. One of the potential efficient measures to ensure the compliance with the provisins of the Polar Code by vessels in the Arctic is the development of a regional port state control mechanism. Such instruments are widely used on the regional level and are highly valued by the International Maritime Organization. Implementation of an Arctic port state control mechanism will require development of a vessel inspections system aimed at ensuring compliance with the Polar Code standards, exchange of information between participating states, in particular on non-compliant vessels and weather forecasts in specific areas of the Arctic. An important element of the Arctic mechanism should be engaging of non-arctic states from Asia and Northern Europe, given that states from these regions would be the ports of departure in case of a transit passage through the Arctic Ocean without entering the Arctic coastal states’ ports. An option of extending the mandate and scope of existing port state control mechanisms is also considered as an alternative to creating a new one specifically for the Arctic. However, this approach would entail more difficulties and would not ensure the needed involvment of all parties concerned.
Economic Transformation of Regions of the Arctic Zone of the Russian Federation
Authors: Gamukin V. V.
Published: January 2020

Post-crisis development of national economy substantially is defined by global trends on restoration of growth rates. It is necessary to use the capacity of macro regions of the country among which the important place is taken by the Arctic Zone of the Russian Federation (AZRF). There is a need for a research of ability of structure of economy of the territorial subjects of the federation entering it in whole or in part to adapta tion to the changing managing conditions. It is important to reveal effectiveness of efforts of large and small business, the regional and federal bodies of authority and management, the available market institutes in general directed to activation of economic factors of AZRF. In article the hypothesis of a possibility of assessment of dynamics of change of this structure with the indicators characterizing structure of the gross regional product (GRP) of the territorial subjects of the Russian Federation included in AZRF is made and considered. The research of structure of this indicator is conducted during 2005–2016 with application of the index of structure offered by the author. It is revealed that during the analyzed period of fluctuation of the sizes of shares in structures of GRP of subjects of AZRF significantly differ among themselves. Entry into AZRF into the analyzed period had no significant effect on change of structure of GRP of the entering territorial subjects of the Russian Federation yet. It says about prevalence of the economic practice which developed under the influence of a geographical factor. In subjects of AZRF the trend on reduction of a share of agriculture, hunting and forestry, the processing productions, transport and communication and financial activity with simultaneous increase in a share of mining proceeds. Significant growth in a share of public administration and ensuring military safety is observed; obligatory social insurance at stagnation of the size of a contribution of education, health care and providing social services. Fluctuations of the sizes of shares in structures of GRP of subjects of AZRF are uneven that speaks about preservation of a trend on a variety of structures of regional economies. The insignificant tendency to more balanced participation of subjects of the district in creation of total amount of GRP due to high dynamics of the extracting sector is revealed. In the Arctic in the analyzed years the industrial logic of development assuming large-scale industrial exploitation of natural resources amplified.
Soviet Scientific Elite of the 1930s under the Patronage of the Commission for the Promotion of Scientists under the Council of People’s Commissars of the USSR: Life, Health, International Book Relations (1934-1937)
Authors: Posadskov A. L.
Published: January 2020

The article is devoted to the history of the Commission for the Promotion of Scientists (CPS) under the Council of People's Commissars of the USSR, which existed in 1931-1937. It is reported that the CPS replaced the Central Commission for the Improvement of the Life of Scientists (CCILS), which had operated under the Council of People’s Commissars of the USSR since 1921. It is shown that in the first years of its existence, the Commission continued the traditional directions of state supervision over the material, logistic, housing, and leisure aspects of the life of Soviet scientists (which was typical for CCILS), and then, from the mid-1930s, the Commission acquired new functions and strengthened some of the previous areas of activity that have become more in demand among scientists. Among these areas, in particular, the propaganda of scientific achievements of the USSR, which had been updated by that time, the provision of scientists with foreign scientific literature, and the improvement of medical and health resort services for the highest stratum of the scientific intellectuals are mentioned. The author of the article claims that the Commission for the Promotion of Scientists was an effective tool for managing the Soviet scientific community from a totalitarian state. It is proved that in the 1930s it solved the problem of “buying” loyalty and devotional service of the top scientific intellectuals to the communist government in exchange for benefits, privileges and preferences.
Information about the Siberian Murza of the Kulmametevs in the light of the Generational Painting of the Late 18th Century
Authors: Tychinskikh Z. A. , Samigulov G. H.
Published: January 2020

The article considers the early stage of the history of the famous Siberian Murza genus Kulmametevs. Documents from the central, regional and local archives became the material for publication, the main of which was the generation of paintings - a document from the State Archives of the Perm Territory, dating to the end of the 18th century and containing information about the service representatives of the genus. Based on the analysis of the complex of various sources, individual moments of the genealogy from the end of the 16th to the 18th century are identified and refined. The origin of the Kulmametevs from Prince Begish of the era of the Siberian Khanate is proved. Based on the analysis of the complex of various sources, individual moments of the genealogy from the end of the 16th to the 18th century are identified and refined. The origin of the Kulmametevs from Prince Begish of the era of the Siberian Khanate is proved. As the prospects of the study the significance of the results obtained for studying both individual significant representatives of the Turkic population of Western Siberia after its inclusion in the Russian state and the features of the formation of the upper stratum of this population, building relations between the top of the serving Tatars and the Russian administration is emphasized.
Front Mater
Authors: Front Mater
Published: January 2020

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Correlation between Alpha Fetoprotein and Platelet Profile in Hepatocellular Carcinoma
Authors: Rahmawati Rahmawati , Abdullah Agus Alim , Samad Ibrahim Abdul
Published: January 2020

Hematology abnormalities are commonly found in Hepatocellular Carcinoma (HCC) patients. Platelet (PLT) count in HCC can be low, normal or high, and influenced by tumor and liver damage. There are limited studies about the correlationp between AFP and platelet profile of HCC in Indonesia, especially in Makassar. This study is aimed to analyze the correlation between AFP and platelet profile in HCC patients. A retrospective cross-sectional study was carried out from  January 2016 to June 2017 on 231 HCC subjects. The correlation between AFP and platelet profile, the correlation of AFP and platelet profile with the diagnosis were analyzed by Independent t-test and Chi-Square. There was no significant correlation between AFP and PLT profile and no significant correlation between AFP and HCC with and without cirrhosis with p>0.05 and p=0.094, respectively. Platelet count and PCT were significantly lower in cirrhotic HCC ompared to non-cirrhotic HCC (p<0.01, p<0.01, respectively), PDW and MPV were significantly higher in cirrhotic HCC compared to non-cirrhotic HCC  (p<0.05, p<0.05,  respectively). Mean platelet count and PCT in cirrhotic HCC were significantly lower compared to non- cirrhotic HCC, and mean PDW and MPV in cirrhotic HCC c were significantly higher compared to non-cirrhotic HCC. Further research was suggested to evaluate tumor size and nodules of HCC.
Correlation between Lactic Acid Concentration and The Severity of Neonatal Sepsis
Authors: Iskandar Agustin , Pranidya Nada Putri , Sulistijono Eko , Aryati Aryati
Published: January 2020

BackgroundsNeonatal sepsis remains a major cause of high infant mortality rate in Indonesia, and served as one of risk factor for early neonatal mortality. This study aims to determine the relationship between lactate levels andthe severity of sepsis and prognostic value of lactic acid as a predictor of severity in neonatal sepsis.. MethodsThis research is analytic observational research using cross sectional method. The subjects were patients of neonatal sepsis treated in the Perinatology Room of Saiful Anwar Hospital Malang from February to June 2015. Lactic acid concentration in plasma was measured by using enzymatic colorimetric  methodResults and DiscussionThe results showed a positive and significant correlation (p = 0,023; r= o,414) between lactate concentration and severity of sepsis, where every increase of sepsis degree increased lactate level of 0,151 mmol / L. Whereas by using  cut off â‰¥ 2.5 mmol / L, the prognostic test showed  66.7% of sensitivity and 76.2% of specificity. The chi square test of lactate> 2 mmol / L and <2 mmol / L showed Odd Ratio (OR) of 1,3 whereas at lactate level > 5 mmol / L and <5 mmol / L showed OR of 4,8 indicated that although there was no difference but the mortality outcomes of neonatal sepsis 4.8 times greater those of life. Thus lactate levelsof > 5 mmol / L can determine mortality outcome of neonatal sepsis.Conclusions and suggestionsThe higher the lactic acid level the more severe of neonatal sepsis. Lactate levels greater than 5 mmol / L was predictor for determining mortality outcome in neonatal sepsis
HASHIMOTO’S THYROIDITIS HYPERTHYROID STAGE
Authors: Hapsari Siti Nurul , Soehita Sidarti
Published: January 2020

Preliminary: Hashimoto thyroiditis (chronic autoimmune thyroiditis) is the most common cause of hypothyroidism in iodine- sufficient areas of the world, but can sometimes show hyperthyroidism. Case: A 39-year-old female was referred due to shortness of breath and tremor, four hours before hospitalization. There was nausea, chest pain, cold chills and palpitation. She was diagnosed with Hashimoto’s thyroiditis and routinely received tyrosol, propanolol and dexamethasone. Physical examination: cervical mass, afebrile, blood pressure 130/70 mmHg, pulse rate 110 x/minute and respiratory rate 20 x /minute. Laboratory examinations showed WBC 7.53 x 109/L, Hb 11.0 g/dL and  platelet count 168 x 109/L.  Chest X-Ray: negative for infiltrates. Several laboratory tests were performed, abnormal results were as follows: FT4 2.96 ng/dL (increased), TSH 0.003 uIU/mL (decreased), anti-TPO (antithyroid microsomal antibody) 306 IU/ml (increased), Ig E 213.6 IU/mL (increased). Peripheral blood smear, coagulation test, serum electrolytes, liver function tests, renal function tests, urinalysis, CEA and Ca 125 were within normal limits. A thyroid ultrasound resulted in a benign lesion. Fine Needle Aspiration Biopsy concluded in lymphocytic Hashimoto’s thyroiditis. Echocardiography showed hyperthyroid heart disease. Discussion: Due to an increase in anti-TPO and  FT4, a decrease in TSH and lymphocytic thyroiditis from FNAB, this patient was diagnosed with Hashimoto’s Thyroiditis Hyperthyroid Stage. Conclusion: Thyroid function tests and thyroid antibody tests must be monitored to decide whether it is hyperthyroid or hypothyroid stage of Hashimoto thyroiditis.
Middle Career Trap
Authors: Johan Suwinto
Published: January 2020

The aim of the paper is to study the middle career trap for white collar worker. The research will be focused on the challenges which are faced by middle management. We will use the qualitative method on the analysis. The sample are 50 midlle managers who have more than 10 years working experience. The analysis will be faced to faced interview basis. The empirical results show that more than 10% of the middle managers are facing financial problem due to life style and family issues. There is a trap for the manager to improve their capabilities due to financial problem. The trap become a hurdle for the manager to promote to next level.
Strategi Manajemen dalam Meningkatkan Daya Saing pada Celebrity Fitness Central Park Mall
Authors: Wiseno Christian Lyonal
Published: January 2020

This research was conducted to find out the most precise management strategy to enhance competitiveness of Celebrity Fitness Central Park Mall. This study applies a qualitative method, by conducting interviews and also observation by directly reviewing the subject of the study. The analytical method consists Input Stage consisting of Internal Factor Evaluation and External Factor Evaluation, Matching Stage consisting of Strength-Weakness-Opportunity-Threat Matrix and Internal External Matrix, and Decision Stage consisting of Quantitative Strategic Planning Matrix. After analyzing from the existing data, it is known that the Market Penetration strategy is the most appropriate to be implemented for Celebrity Fitness Central Park Mall and Market Development strategy can be used as a support.
Pengaruh Brand Image, Product Involvement, dan Brand Engagement Terhadap Purchase Intention Teh Pucuk di Kota Jakarta
Authors: Chairy Annisa Intan Ramadhan Dan
Published: January 2020

This research aims to find out influence of Brand Image, Product Involvement, and Brand Engagement to Teh Pucuk’s Purchase Intention in Jakarta. Research conducted by distributing questionnaires to 272 respondents randomly. Analysis technique used is technique of quantitative analysis. Data of this research was taken from August until Dec 2018. The research data was analyzed by SmartPLS application. The results showed that Brand Image, Product Involvement, and Brand Engagement had significantly influence on Teh Pucuk’s Purchase Intention. The population in this study were people living in Jakarta, researchers took samples of 272 respondents using the questionnaire method. The sampling technique used is simple random sampling, where each element of the population has the same opportunity to be selected as a sample. Brand Engagement had influence Purchase Intention; Brand Image had influence Brand Engagement; Brand Image had influence Purchase Intention; Product Involvement had influence Brand Engagement; and Product Involvement had influence Purchase Intention. Also this research had indirect effect, that Brand Engagement had influence as mediator between Brand Image and Purchase Intention and Product Involvement and Purchase Intention.
Pelatihan Menulis Penelitian Tindakan Kelas Bagi Guru TK Se-Kecamatan Pauh Di Kota Padang
Authors: Ayendi Ayendi , Najma Eva , Novalinda Novalinda
Published: January 2020

Tema kegitan pengabdian yang dilaksanakan pada tanggal 27 Oktober 2014 ini adalah “Pelatihan Menulis Penelitian Tindakan Kelas (PTK) bagi Guru TK Se-Kecamatan Pauh di Kota Padang”. Adapun yang melatarbelakangi diadakannya pelatihan ini adalah para guru TK tersebut memiliki pengetahuan yang kurang terhadap bagaimana melakukan penelitian, terutama PTK. Hal ini disebabkan latar belakang pendidikan para guru TK tersebut yang kebanyakan tamatan PGTK Diploma II, dan juga ada yang berasal dari jurusan non- kependidikan. Para guru TK saat sekarang ini dituntut untuk dapat mengembangkan dirinya dan profesional dalam segala hal dalam menjalankan tugas dan fungsinya. Pengembangan diri ini dapat dilihat dari portofolio yang mereka miliki, disamping sertifikat pelatihan juga adalah laporan penelitian yang dipublikasikan maupun tidak dipublikasikan. PTK itu sendiri adalah suatu bentuk penelitian reflektif diri sendiri yang memiliki siklus yaitu Perencanaan, Pelaksanaan, Monitoring dan Evaluasi, dan Refleksi. Metode pelatihan yang diterapkan adalah melalui presentasi, diskusi dan tanya jawab. Peserta yang hadir terdiri dari 44 orang guru TK yang berasal dari 12 sekolah TK yang ada di Kecamatan Pauh kota Padang. Hasil dari pelatihan ini mampu meningkatkan pemahaman para guru TK se-Kecamatan Pauh tentang apa itu PTK, bagaimana melakukannya, dan bagaimana membuat laporan/makalahnya.
Miejsce Biblii w życiu Ulricha Zwingliego
Authors: Jaskóła Piotr
Published: January 2020

Artykuł prezentuje centralne miejsce Biblii w życiu U. Zwingliego. Reformacja w Zurychu, której początki były głównie jego dziełem, ujawniła to na kilku polach: w kaznodziejstwie, prowadzonych dysputach teologicznych i w tzw. „szkole proroctw” (Prophezei). Na każdym z tych pól szwajcarski reformator eksponował autorytet Biblii – nieporównywalny z innymi autorytetami. Równocześnie podkreślał rolę Ducha Świętego w interpretacji tekstów biblijnych. Prawda o inspirującym działaniu Ducha Świętego, jak i prawda o suwerenności Boga leżą u podstaw życia i teologicznego dziedzictwa reformatora z Zurychu.
Ten years of Ordinariates for Anglicans – a few reflections on the new ecclesiological model
Authors: Kantyka Przemysław Jan
Published: January 2020

The article describes the Ordinariates for Anglicans from the ecclesiological point of view. The publication of Pope Benedict XVI’s Apostolic Constitution Anglicanorum coetibus created a new situation in the interconfessional relations and in the search for the unity of the Church. Firstly the Author explains what are the Ordinariates for Anglicans and what solutions contains the Apostolic Constitution Anglicanorum coetibus. In the second point of the article we find an analysis of an ecclesiological model created by the constitution Anglicanorum coetibus. While not being the return to the past method of gaining the unity of the Church by partial unions (i.e. so called “uniatism” or “unionism”) the Ordinariates offer to the conversing Anglicans the possibility of upkeeping their liturgical tradition. The Ordinariates also enjoy a large scale of independence in the frame of the Catholic Church. Alongside the bright spells there are also some shadows. The Author points at the major ecclesiological weakness of the construction called “Ordinariate”. The liturgical tradition of Anglicanism transferred to the Ordinariates is, in fact, deprived of its natural theological background, which is Anglican. That is why the solution offered by the Ordinariates one of the Anglican theologians called “the shortened version of Anglicanism”. The last point of the article is consecrated to the depiction of first Anglican reactions to the situation introduced by the apostolic constitution Anglicanorum coetibus. The most promising initiative is the establishment of so called “Anglican Communion Covenant”, which is designated to consolidate the Communion from inside, also by preventing the provinces from taking unilateral decisions leading to the breaks in the whole of the Anglican World.