bluuebunny/crossref_metadata_2025 huggingface dataset:
Antioxidant, antibacterial, and anticancer properties of Haloxylon salicornicum extracted by microwave-assisted extraction
Authors: Yousif Aala A. , Al-Shawi Ali A.A. , Hameed Mustafa F.
Published: September 2021

Background

The wild plant Haloxylon salicornicum is a desert shrub species that is present in North America and some Middle Eastern countries and is used as a source of vegetation. The reports demonstrated the significance of its bioactive compounds by extracting them with different solvents, such as hexane, methanol, and water fractions using standard extraction methods and evaluating their biological functions as antioxidants, antibacterial, and anti-inflammatory.

Objective

To analyze the chemical compositions of H. salicornicum extracted by microwave-assisted extraction (MAE) using the antioxidant, antibacterial, and anticancer activities.

Materials and methods

In this research, ethanol solvent and simple MAE with gas chromatography–mass spectrometry analysis were used to classify the chemical compositions, and the ethanol extract was evaluated for antioxidant activity using the 2,2-diphenyl-1-picrylhydrazyl process, antibacterial activity, anticancer activity using liver cancer cells (HCAM) through apoptosis (AO/EB staining), and flow cytometry analysis for apoptosis and cell cycle arrest ratios.

Results and conclusion

The gas chromatography–mass spectrometry study revealed ∼33 compounds. H. salicornicum antioxidant activity was IC50=4.120 μg/ml as compared with vitamin C IC50=4.898 μg/ml as a positive regulation. Antibacterial activity of H. salicornicum extract showed a significant inhibition toward Staphylococcus aureus and Escherichia coli.
H. salicornicum cytotoxicity against liver cancer cells (HCAM) at 1000 μg/ml showed a significant inhibition ratio (42.35%). The AO/EB staining revealed DNA damage and apoptosis in the morphology of the cells. Early and late apoptosis were established, and the cell cycle was stopped in G1 phase. Our findings indicate that H. salicornicum is a valuable medicinal plant with biological applications. As a result, future research will focus on isolating the responsible natural molecules using MAE and mechanic studies.
Cohort profile: the Environmental-Pollution-Induced Neurological EFfects (EPINEF) study: a multicenter cohort study of Korean adults
Authors: Jang Heeseon , Kim Woojin , Cho Jaelim , Sohn Jungwoo , Noh Juhwan , Seo Gayoung , Lee Seung-Koo , Noh Young , Oh Sung Soo , Koh Sang-Baek , Kim Hee Jin , Seo Sang Won , Kim Ho Hyun , Lee Jung Il , Kim Sun-Young , Kim Changsoo
Published: September 2021

The general population is exposed to numerous environmental pollutants, and it remains unclear which pollutants affect the brain, accelerating brain aging and increasing the risk of dementia. The Environmental-Pollution-Induced Neurological Effects study is a multi-city prospective cohort study aiming to comprehensively investigate the effect of different environmental pollutants on brain structures, neuropsychological function, and the development of dementia in adults. The baseline data of 3,775 healthy elderly people were collected from August 2014 to March 2018. The eligibility criteria were age ≥50 years and no self-reported history of dementia, movement disorders, or stroke. The assessment included demographics and anthropometrics, laboratory test results, and individual levels of exposure to air pollution. A neuroimaging sub-cohort was also recruited with 1,022 participants during the same period, and brain magnetic resonance imaging and neuropsychological tests were conducted. The first follow-up environmental pollutant measurements will start in 2022 and the follow-up for the sub-cohort will be conducted every 3-4 years. We have found that subtle structural changes in the brain may be induced by exposure to airborne pollutants such as particulate matter 10 μm or less in diameter (PM10), particulate matter 2.5 μm or less in diameter (PM2.5) and Mn10, manganese in PM10; Mn2.5, manganese in PM2.5. PM10, PM2.5, and nitrogen dioxide in healthy adults. This study provides a basis for research involving large-scale, long-term neuroimaging assessments in community-based populations.
COVID-19 outbreak, herd immunity formation, and future public health strategies
Authors: Kim Youngtaek , Park Yoon Hyung
Published: September 2021

In Korea, where the successful control of the coronavirus disease 2019 (COVID-19) epidemic have been implemented by the follow-up survey management (containment) of COVID-19-infected persons, the number of infected persons has increased rapidly, and a re-epidemic trend is emerging. The Korean government is strengthening epidemic prevention activities, such as increasing the social distance in the metropolitan area to four levels and increasing the vaccination rate. The public has been complaining of dissatisfaction with the atrophy of socioeconomic activities and of distrust of epidemic prevention policies. Australia started with an incidence similar to that of Korea, but its social activities are more flexible than those of Korea, where the incidence is maintained at approximately 0.1 per 100,000 people. In comparing the differences between both countries in terms of the Oxford COVID-19 Government Response Tracker Stringency Index, it was found that Australia effectively regulates the number of infected cases by high-intensity intermittent mitigation and the subsequent allowance of social activities. Korea has also recommended a high-intensity intermittent mitigation policy as in Australia until community herd immunity via vaccination is formed.
Partial replacement of DL-Methionine and methionine hydroxy analogue with betaine in diets for broiler chickens
Authors: Silva L. , Vieira B.S. , Castilha L.D. , Takahashi S.E. , Avila A.S. , Souza C. , Cella P.S. , Broch J. , Nunes R.V.
Published: September 2021

The study evaluated the effects on the growth performance and carcass characteristics of broiler chickens of DL-Methionine (DL-Met) and methionine hydroxy analogue (MHA) supplementation and their partial replacement with betaine (Bet). Two experiments were performed from day 1 to 21 and from day 22 to 42. Broiler chickens were assigned to six treatments, in a completely randomized design and a 2 × 2 + 2 factorial arrangement, consisting of two Met sources (DL-Met and MHA), with or without Bet, and two negative controls. The six treatments consisted of i) NC-DLM: negative control for DL-Met with 7% reduction in DL-Met; ii) NC-MHA: negative control for MHA with 7% reduction of MHA, iii) DLM100: without Bet, supplemented exclusively with DL-Met reaching 100% of requirements, iv) MHA100: without Bet supplemented exclusively with MHA reaching 100% of requirements, v) DLM93+Bet: DL-Met at 93% of recommended level plus betaine; vi) MHA93+Bet: MHA at 93% of recommended level plus betaine. Growth from day 1 to 21 was not altered by methionine source or betaine supplementation. However, the negative controls had numerically less weight gain and feed conversion ratio (FCR) . Between days and 42 there were no effects on growth. Betaine could partially replace methionine without altering the growth of broiler chickens. In addition, the partial replacement of DL-Met with betaine increased body crude protein content. However, its use increased body fat content regardless of methionine source.
Statistical assessment of feeding corn with higher oil content to piglets in the starter phase
Authors: Silva M.A.A. , Carvalho P.L.O. , Paiano D. , Silva M.A. , Genova J.L. , Grando M.A. , Carvalho S.T.
Published: September 2021

The aim of this study was to assess the digestibility coefficients (DC) of corn [maize] with an oil content above 3.46% and its effects on the performance of piglets when fed as dry grain (DG) and as rehydrated corn grain silage (RCGS). In Experiment I, 15 piglets (22.51 + 2.39 kg) were allocated to a reference diet (RD) and to two test diets in which corn in the RD was replaced with DG or RCGS. There were five replications of each treatment. Experiment II involved 36 piglets (14.76 ± 2.72 kg), which were assigned to a control diet with common corn grain and to diets in which DG or RCGS replaced the common corn. There were six replications of each treatment. Data were analysed with four statistical models. Model 1 included only the effect of treatment. Model 2 was similar to Model 1 but included initial bodyweight as a covariate. Model 3 was similar to model 1 but included the interaction of diet and period. Model 4 was similar to Model 3 but included the covariate. The more complicated models were generally preferred to Model 1 as they controlled more of the nuisance variation. Feeding a diet that contained RCGS reduced feed intake and improved feed conversion ratio (FCR).
Behavioral Models of Population Inhabiting the Fortresses in the South of Russia in the 17th century (as Documented in Voronezhsky, Kozlovsky and Tambovsky counties)
Authors: Lyapin Denis A. , Mizis Yuri A.
Published: September 2021

The article discusses the process of formation of the main behavioral patterns of the population of the southern counties during the period of the settlement in and development of the South of Russia in the 17th century. The authors analyze the behavior of migrants to the steppe periphery of the country, on the basis of large archival source. An important place in the development of steppe territories was occupied by fortresses, which were military, political and religious centers for the counties. The strong influence of collectivist principles is noted in the article. Particular attention is paid to studying the dynamics of changes in the social environment in the South of Russia, the formation of property stratification, the emergence of individualism. It is argued in the paper that social changes were associated with shifts in the behavioral models of the inhabitants of the fortresses: if at the early stage of its existence the population of the towns consisted of a single mass of the servicemen, then the second half of the 17th century is characterized by a gradual destruction of social cohesion. The behavioral models of servants and townspeople were determined by the desire for personal gain, material wealth, and individual benefits. This was due to the increase in the number and importance of townspeople, whose lives were a constant competition. Discovered shifts of behavioral patterns are indicative of important changes in society.
Experience of using the interactive application "AcademiХ3D" in the context of the COVID-19 pandemic in the educational process of students of the medical faculty.
Authors: Bank Mariya , Nevskaya Nina
Published: September 2021

An analysis of the experience of using the interactive application "Academics 3D" in the context of the COVID-19 pandemic in teaching students of the medical faculty is presented. Virtual technologies make it possible to optimally distribute the time limit and stages of mastering practical skills in the professional training of doctors. The analysis showed the significance, prospects and ways of increasing the efficiency of using simulation technologies in the process of training doctors.
Stopping life-threatening bleeding is one of the essential skills of simulation training in emergency medical care
Authors: Chursin A. A. , Lytkina A. S. , Podoprigora A. V. , Boev S. N.
Published: September 2021

More than 5 million people around the world die every year from severe injuries and their complications, among which massive blood loss is in the first place. The introduction of practical exercises for training in stopping massive bleeding using simulators and modern means will not only improve the quality of care at the prehospital and early hospital stages, but also significantly improve the process of all simulation training.
The Effectiveness of a New Approach to Teaching Botulinum Toxin Injection Technique Using Simulation Equipment
Authors: Tarasova G. N. , Grigorieva V. P. , Smirnova E. A. , Mamedova L. N.
Published: September 2021

Botulinum toxin injections are currently the most common direction in cosmetology. The continuing frequency of medical errors during this procedure dictates the search for new methodological approaches in training specialists using interactive and highly realistic simulation equipment.
Improving the Effectiveness of Critical Thinking Among Residents and Students of Surgical Departments
Authors: Murasov T. M.
Published: September 2021

The purpose of the work was: the development of a non-costly, effective method for assessing students' knowledge, which would stimulate the interest of a medical student in the educational process. The assessment method consists in the fact that in advance the teacher will date the students or residents to prepare an analysis of the standard protocol of surgery for basic surgical pathology. During the lesson, the teacher reports that there are 3 errors in the protocol of the same operation, which he will now read. The student's goal is to find them. The mistakes are made by the teacher.
Features of Simulation Training of Emergency Medical Care for Doctors of Nonurgent Specialties in the Framework of Continuing Medical Education
Authors: Lovchikova I. A. , Chursin A. A. , Podoprigora A. V. , Boev S. N. , Boev D. E. , Vislova O. P. , Sergeeva O. S. , Zhukov A. A.
Published: September 2021

According to the current legislation medical institutions of any specialization and form of ownership are obliged to provide emergency medical care without delay and free of charge. Emergency medical care is not a profile one for many specialists and, within the framework of the current law, it is necessary to introduce an emergency medical care course into the CME system for all medical specialties at least once every five years, which will correspond to both the previously adopted system of postgraduate education and the existing standards of work of medical facilities.
Student-Patient Communication. A View from the Practitioner
Authors: Murasov T. M. , Murasov A. M.
Published: September 2021

The main goal of communication skills in medicine was considered to be the acquisition of the necessary knowledge for the diagnosis and implementation of effective treatment. This goal is still a priority. But taking into account the development of review sites, increasing the availability of awareness, a new item appeared that interested medical and educational institutions. This is the rating of the institution. The rating is built on two main points: 1) technical equipment, personnel and new technologies and 2) public opinion about the institution. Institutional opinion is based on the opinion of patients or students.
Educational Adaptation and Digital Transformation in the Context of the Novel Coronavirus Infection COVID-19
Authors: Shlyakhto E. V. , Parmon E. V. , Kosyakov G. V. , Kukharchik G. A.
Published: September 2021

The materials highlight the experience of digital transformation and educational adaptation to the conditions of the novel coronavirus infection. The report presents new formats for organizing training sessions and practical training, tested in V.A. Almazov National Medical Research Center.
From ex situ simulation to in situ simulation in the "Comprehensive educational program to reduce infant mortality in the Khabarovsk Territory"
Authors: Nevskaya N. A. , Plotonenko Z. A. , Senkevich O. A.
Published: September 2021

Infant mortality is an important statistical indicator, and at the same time an indirect criterion of the economic, social and political component of the state. The experience of conducting simulation training "in situ" within the framework of the "Comprehensive educational program to reduce infant mortality in the Khabarovsk Territory" is presented.
Methodological Approach to Updating the Structure of Accreditation Materials for a Specialty for Primary Specialized Accreditation of Specialists
Authors: Parolina L. E. , Otpuschennikova O. N.
Published: September 2021

The methodological approaches to updating the list of the main sections of the specialty, which are the basis for the preparation of assessment materials for primary specialized accreditation, taking into account the professional competencies of specialists, are presented.
Process Factory as Simulation Training
Authors: Kabirova Yu. A. , Rudin V. V. , Isaeva N. V.
Published: September 2021

The authors present the experience of combining simulation training in clinical skills and training in lean technologies at the "Process Factory"
Analysis of the structure of the main errors of ordinators in the specialty «anesthesiology-reseanimatology» by the results of the first specialized accreditation in 2021
Authors: Dragovoz E. A. , Grigorian M. F. , Dolzhenkova I. G.
Published: September 2021

The work proves the need for systematization of theoretical knowledge and regular training in a simulation center.
ORGANISMOS MULTILATERAIS E ENTIDADES FISCALIZADORAS NO PROCESSO DE EMPRESARIZAÇÃO DO ESTADO: A GOVERNANÇA DAS AQUISIÇÕES
Authors: Passos Silveira Juliana , Rodrigues Marcio Silva
Published: September 2021

O artigo analisa a empresarização do Estado e o papel exercido por organismos multilaterais internacionais e entidades fiscalizadoras superiores na indução deste processo, através da atuação do Tribunal de Contas da União (TCU) junto a área de aquisições públicas, visando o estabelecimento de uma governança que traduz os princípios da governança corporativa ao setor público. Foram utilizadas perspectivas teóricas sobre o conceito de governança pública e os processos de empresarização do mundo contemporâneo e a generalização da “forma empresa” na sociedade. Realizou-se análise documental através de documentos e estudos oficiais, cartilhas, manuais, legislação e normativos infralegais que consolidaram a governança das aquisições no âmbito da administração pública federal, demonstrando a ideia de empresa como paradigma de gestão para a área de aquisições públicas, analisando-se as seguintes dimensões: a ideia de empresa como paradigma para a gestão pública e a lógica empresarial estabelecida no conceito de governança pública.
Infecções em lúpus eritematoso sistêmico
Authors: Proença Adriana Coracini Tonacio de
Published: September 2021

Pacientes lúpicos estão mais sujeitos à infecção se comparados aos imunocompetentes. Isso se explica tanto pela imunossupressão relacionada com doença, como pelo uso de drogas imunossupressoras. As infecções, por sua vez, também figuram entre as principais causas de óbito entre os lúpicos, o que torna imprescindível aos profissionais que cuidam destes pacientes estarem a par das particularidades do tema nesta população específica. Serão discutidos os principais agentes infecciosos implicados, bem como considerações clínicas, diagnósticas e abordagem preventiva, quando disponível.
Os principais agentes abordados nesta breve discussão são: vírus respiratórios, herpes-zóster, citomegalovírus, parvovírus B19, infecções bacterianas comunitárias, infecções fúngicas invasivas e micobactérias.
Outro aspecto relevante é a difícil diferenciação em quadros febris entre atividade de doença, processo infeccioso ou ambos apresentando-se de forma concomitante. Discutiremos os parâmetros que podem ser utilizados para auxiliar na elaboração diagnóstica.

Unitermos: Lúpus eritematoso sistêmico. Infecção em imunossuprimidos. Imunossupressão. Citomegalovírus. Infecção.
Alvos terapêuticos em osteoporose
Authors: Domiciano Diogo S.
Published: September 2021

Indivíduos que estão sob risco iminente de fratura por osteoporose (ou seja, risco de fratura nos próximos dois anos) são aqueles com muito baixa densidade mineral óssea, história de fratura recente, idade avançada e presença de quedas recorrentes. A estratégia treat-to-target, recentemente incorporada às diretrizes de tratamento da osteoporose, preconiza uma meta terapêutica objetiva a ser atingida, no caso, o mais baixo risco de fratura possível. Análises dos ensaios clínicos pivotais das drogas antifratura sugerem um T-score > -2,5 (preferencialmente > -2,0) como possível alvo de tratamento clinicamente útil associado a um nível aceitável de risco de fratura. A droga capaz de levar mais rapidamente à obtenção desse alvo deve ser a primeira escolha terapêutica. Decisões subsequentes devem ser tomadas de acordo com a resposta na obtenção do alvo desejado2,23. Os fármacos atualmente disponíveis em nosso meio com efeito benéfico comprovado em pacientes de alto risco de fratura são: alendronato, risedronato, ácido zoledrônico, denosumabe e teriparatida. O tratamento deve oferecer, no mínimo, 50% de chance de atingir o alvo terapêutico dentro de 3 a 5 anos do início da terapia. Neste artigo, revisaremos os conceitos de risco de fratura iminente e a melhor abordagem terapêutica para os pacientes de elevado risco, considerando a estratégia treat-to-target em osteoporose.

Unitermos: Osteoporose. Risco de fratura. Treat-to-target. T-score. Fatores de risco.
Biomarcadores em Hepatologia
Authors: Oliveira Elze Maria Gomes , Ferraz Maria Lucia Gomes
Published: September 2021

As hepatopatias autoimunes compõem um conjunto de doenças, entre as quais se destacam a hepatite autoimune, a colangite biliar primária e a colangite esclerosante primária. A determinação sérica de autoanticorpos é de fundamental importância para o diagnóstico dessas doenças, assim como para acompanhamento terapêutico e estabelecimento de critérios prognósticos. Entre os autoanticorpos disponíveis na prática clínica, os mais utilizados na abordagem das doenças hepáticas autoimunes são o anticorpo contra antígenos celulares, chamado de anticorpo antinúcleo (FAN), o anticorpo antimúsculo liso (AML), o anticorpo antimitocôndria (AMA) e o anticorpo antimicrossoma de fígado e rim (anti-LKM1). Na avaliação de anticorpos nas doenças hepáticas, tanto títulos, como padrões e comportamento ao longo do tempo são extremamente importantes para estabelecimento do correto diagnóstico, tendo em vista que esses marcadores carecem de especificidade e podem estar expressos de forma isolada ou em diferentes combinações. Em conjunto com outros elementos, como as determinações bioquímicas e o estudo histológico, permitem estabelecer com maior precisão o diagnóstico correto de cada doença. A presente revisão aborda o papel de cada biomarcador nas diversas doenças hepáticas de natureza autoimune, procurando estabelecer a relevância para o diagnóstico e a orientação prognóstica, incluindo o uso de marcadores menos utilizados na prática clínica, mas que vêm se mostrando de grande importância para auxiliar no diagnóstico e acompanhamento dos pacientes, tais como o anticorpo antiantígeno hepático solúvel fígado-pâncreas (anti-SLA/LP), o anticorpo anticitosol hepático (ALC1) e os anticorpos anti-Sp100 e anti-gp210.

Unitermos: Autoanticorpos. Hepatite autoimune. Colangite biliar primária. Colangite esclerosante primária. Síndrome de sobreposição.
Aplicabilidade de biomarcadores em miopatias autoimunes sistêmicas
Authors: Shinjo Samuel Katsuyuki , Souza Fernando Henrique Carlos de
Published: September 2021

As miopatias autoimunes sistêmicas são um grupo heterogêneo de doenças raras que acometem primariamente a musculatura esquelética. Entretanto, outros órgãos e sistemas podem estar afetados. Entre diversos biomarcadores disponíveis, serão abordados no presente estudo os autoanticorpos miosite-específicos e miosite-associados que têm sido caracterizados e correlacionados com diversas manifestações fenotípicas dessas doenças.

Unitermos: Autoanticorpos. Autoimunidade. Biomarcadores. Miopatias inflamatórias. Miosite.
Prescrição de atividade física em pacientes com doenças reumáticas
Authors: Lima Fernanda Rodrigues , Peçanha Tiago
Published: September 2021

A inatividade física e o sedentarismo são comportamentos comuns à maior parte das doenças reumáticas, levando a uma piora do controle destas doenças e a uma menor qualidade de vida. Por outro lado, estudos recentes têm demonstrado que a adoção de um estilo de vida ativo pode auxiliar no tratamento das doenças reumáticas, seja promovendo um melhor controle dos sinais e sintomas ou atenuando diversas comorbidades. O objetivo da presente revisão foi apontar aspectos importantes para a prescrição de atividade física (AF) nas doenças reumáticas. Em geral, um programa de AF voltado à saúde de pacientes com doenças reumáticas deve envolver uma equipe multidisciplinar, que será responsável por realizar as avaliações, o planejamento, a entrega e supervisão do programa. Adicionalmente, o paciente deve ser considerado parte fundamental no sucesso da intervenção, visto que ele precisa aderir de maneira ativa à AF, sendo corresponsável pela execução do programa. Um programa de AF para esta população deve objetivar a melhora da aptidão cardiorrespiratória, força muscular, flexibilidade e desempenho neuromotor. Essas capacidades físicas devem ser desenvolvidas por um programa de treinamento físico que componha o treinamento aeróbio, de força, de flexibilidade e neuromotor. Mais recentemente, novas modalidades/abordagens têm sido incorporadas no tratamento de pacientes com doenças reumáticas, tais como o treinamento intervalado de alta intensidade, o treinamento de força com oclusão vascular e a redução do tempo sedentário. É importante que os profissionais de saúde incorporem estas informações no manejo de pacientes com doenças reumáticas.

Unitermos: Exercício físico. Reumatologia. Doenças articulares. Comportamento sedentário. Intervenções comportamentais.
Exercício físico nas miopatias autoimunes sistêmicas: novas evidências para um antigo aliado
Authors: Santos Alexandre Moura dos , Oliveira Diego Sales de , Misse Rafael Giovane , Souza Jean Marcos de , Shinjo Samuel Katsuyuki
Published: September 2021

Por muito tempo a prática de exercício físico foi considerada problemática em pacientes com miopatias autoimunes sistêmicas, partindo-se do pressuposto de que o exercício físico pudesse reativar ou exacerbar a resposta inflamatória autoimune. Entretanto, nos últimos anos, numerosas evidências asseguram que a prática regular de exercícios físicos é segura e eficaz sobre a manutenção da massa e força muscular, melhora a qualidade de vida, reduz a prevalência de comorbidades, sobretudo as cardiovasculares e seus fatores de risco, entre outros benefícios. Neste contexto, o presente estudo tem como objetivo compilar as evidências recentes sobre o papel do exercício físico em pacientes com miopatias autoimunes sistêmicas. Unitermos: Exercício físico. Miopatias inflamatórias. Miopatias autoimunes sistêmicas. Miosites.
Exercícios físicos nas espondiloartrites
Authors: Jennings Fabio
Published: September 2021

As espondiloartrites são doenças inflamatórias sistêmicas que podem causar redução da capacidade funcional, da aptidão física e levar a danos articulares estruturais. Os exercícios físicos fazem parte do tratamento das EpAs no sentido de reduzir o impacto na funcionalidade como também na melhora da atividade de doença e do condicionamento físico geral. As evidências científicas atuais apontam resultados benéficos dos exercícios nos pacientes com espondiloartrites, mesmo naqueles em uso das terapias biológicas. O artigo revisa as principais evidências e os guidelines atuais para a prescrição dos exercícios nas EpAs.

Unitermos: Espondiloartrites. Exercício físico. Fisioterapia. Tratamento. Qualidade de vida.
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI AUDIT DELAY PELAPORAN KEUANGAN PADA PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BURSA EFEK INDONESIA
Authors: Damanik Hormaingat , Sinaga Sarman , Buulolo Renungkan
Published: September 2021

Audit delay is a delay in submitting or publishing the company's financial statements which can make a financial report quality doubtful by the parties interested in making decisions. The purpose of this study is to test and analyze the effect of profitability, solvency, and KAP size on audit delay in financial report submission in consumer goods industrial sector manufacturing companies listed on the IDX for the period 2017 - 2019. In this study there are 3 independent variables, namely profitability. , solvency and hood size and the dependent variable there is 1, namely audit delay. The sampling method used in this research is purposive sampling method. The total population in this study were 36 companies and then eighteen (18) companies fulfilled the purposive sampling. The type of regression model used in this study is logistic regression, then to test the research in logistic regression using Statistical Product and Service Solution (SPSS) version 22.0 for windows using simultaneous test (Omnibus Test Of Model Coefficient) and Wald test (partial). The results in this study indicate that together (Simultaneous Test) all independent variables affect audit delay where the Chi-square value is 4.291 with a significance value of 0.032 <0.05, then the hypothesis is accepted. Then in the Wald Test only the KAP size variable affects audit delay significantly where the Wald test value is 2.068 with a significance of 0.048 <0.05, so the hypothesis is accepted. Meanwhile, the profitability and solvency variables have no effect on audit delay where the Wald test value is 0.663> 0.05 and 1.187> 0.05, so the hypothesis is rejected.
ORNAMENTS OF LAPO BATAKIN KUALA TANJUNG, BATUBARA REGENCY A SEMIOTICS INTERPRETATION
Authors: Manullang Elisa Betty , Lizasadela Windy
Published: September 2021

This article aims to clarify the semiotic meaning in Lapo Batak ornaments in Kuala Tanjung, Batubara Regency. The data of this study were taken from the interpretation from Batak Toba people who live in Kuala Tanjung, Batubara Regency is located in North Sumatera Indonesia in interpreting their cultural symbols. In clarifying the data, the writer was conducted by using qualitative method. The result showed the semiotic meaning and how the cultural values were realized in Lapo Batak ornaments. The dates were analysed by using Roland Barthes’ order of signification theory; denotation, connotation, and myth to emphasize the interaction between the sign with the personal cultural experience of the viewers, and the interaction between convention in the sign with the conventions experienced and expected by viewers. The writer found that the interpretations of the personal cultural experience from the viewers were still far from the Batak Toba convention (myth) in interpreting the ornaments.
FLOUTING MAXIM PERFORMED BY THE MAIN CHARACTER IN THE EDGE OF SEVENTEEN MOVIE
Authors: H Tracy Rabecca , Lubis Masdiana , Nasution Ely Hayati
Published: September 2021

In this research, there are two objectives. First, to identify the kinds of flouting maxim performed by the main character in The Edge of Seventeen movie and Second, to find out the effect of flouting maxim performed by the main character in the movie. The method used in this research is descriptive qualitative method. The data of this research are twenty dialogues of The Edge of Seventeen movie which is containing flouting maxim. In analyzing the data, the researcher found that Nadine as the main character of the movie flouted all types of maxim. The most flouting maxim used by Nadine is floating maxim of quantity and, the least flouting maxim performed by Nadine are flouting maxim of quality and flouting maxim of manner. For the effects, Nadine gave seven effects based on Austin’s Perlocutionary effect theory to the other character of the movie. The seven effects based on Austin’s theory are annoying, boring, convincing, causing, getting the hearer realize something, getting the hearer to do something, and insulting. Further, the effect that mostly performed by Nadine in the movie is getting the hearer realize something effect.
Prototype of IoT-Based Fruit Alcohol Level Measurement Tool
Authors: Nursila Nursila , Ilham Dirja Nur , Yunan Amsar , Harahap Muhammad Khoiruddin , Candra Rudi Arif
Published: September 2021

The effect of alcohol on health is very large if you consume too much, and the fact that excessive alcohol levels can interfere with digestion can cause eye function disorders, decreased brain and nerve function as well as cancer. Knowing the alcohol content in fruits that are suitable for consumption by the body from an early age is very important. Based on this problem, this study aims to create a prototype measuring instrument for the alcohol content of fruits using the Blynk application. This circuit consists of 3 circuits, namely the input part in the form of an Mq3 sensor, the control part in the form of Nodemcu, and the output port in the form of the Blynk application. From the results of testing tools for four samples including durian, grapes, papaya, and apples for 25 times the test of the fruit is peeled for the next 2 hours the average percentage of durian alcohol content is 28.57%, grapes are 12.68%, papaya is 5.79 %, and apples by 18.6%. In this study, there is also the notification facility to the third smartphone that the alcohol content exceeds the alcohol content which is not good from the value set on the device.
A Prospective Study Of Management of Fracture Shaft Femur by
Closed Interlocking Nail in adults
Authors: Goyal Ankesh , Beniwal Brijmohan , Marotia Anilkumar
Published: September 2021

Introduction: Fractures of femoral shaft are among the
most common fractures that orthopedic surgeons encounter.
Femoral shaft fractures can be managed conservatively or
surgically. The surgical treatment has gone into revolutionary
changes over the period of time and with advent of new
antibiotics and better surgical procedures, even open fractures
can be fixed internally. The method studied for this research is
Surgical Management of Fracture Shaft of Femur with
Intramedullary Interlocking Nail.
Aim : to study the effectiveness of interlocking
intramedullary nailing of diaphyseal fracture of femur in adults.
We also studied complications of interlocking intramedullary
nailing.
Methods : This prospective short term study was
done from October 2018 to December 2019 in 20 patients with
20 diaphysis fracture of femur who were admitted in SDM
Hospital, Jaipur and who were treated with A.O. femoral
interlocking nail. The patients were followed for about 1 year.
Results : Majority of fractures were oblique-8(40%),
comminuted fractures in 5(25%), spiral fractures in 4 (20%)
and transverse in case of 3(15%) of fractures. Excellent result
were obtained in 10 cases (50%), good result were obtained in
7 cases (35%) and fair result in 3 cases (15%).
Phân tích thành phần, tính chất sản phẩm khí và condensate mỏ Thiên Ưng
Authors: Khoa Nguyen Ba , Anh Nguyen Huynh , Tri Nguyen Phan , Thu Nguyen Thi Anh , Phong Nguyen Hien , Hop Nguyen Xuan , Loan Ngo Thi , Hai Luong Thi Hong , Lam Nguyen Van , Tung Nguyen Thanh , Hung Nguyen Van , Khoi Truong Huu Dang
Published: September 2021

Bài báo giới thiệu kết quả phân tích thành phần, tính chất mẫu khí và condensate mỏ Thiên Ưng, so sánh với tính chất sản phẩm khí và condensate khác tại Việt Nam. Khí tự nhiên mỏ Thiên Ưng có thành phần chủ yếu là methane với hàm lượng dao động từ 75,231 - 76,402 %mol. Tổng các thành phần hydrocarbon còn lại trong khí mỏ Thiên Ưng chiếm từ 7,083 - 7,123 %mol, trong đó hàm lượng hydrocarbon lỏng (C6+) rất thấp, từ 0,172 - 0,226 %mol. Khí mỏ Thiên Ưng là khí ngọt, có hàm lượng H2S dao động từ 0,3 - 1,5 ppm.Condensate Thiên Ưng có khối lượng riêng ở 15 oC là 0,7743 g/mL nên thuộc loại condensate trung bình so với các loại condensate đã từng khai thác trước đây tại Việt Nam. Hiệu suất phân đoạn naphtha trong condensate Thiên Ưng khá cao (61,39 % khối lượng). Hàm lượng aromatic thuộc loại trung bình, mang đặc tính chung của dầu thô và condensate Việt Nam (hàm lượng lưu huỳnh, ni-tơ, nhựa và asphaltene đều thấp; hàm lượng kim loại vi lượng nickel, vanadium rất thấp).Kết quả nghiên cứu này bổ sung vào hệ thống cơ sở dữ liệu tính chất dầu khí Việt Nam, từ đó giúp lựa chọn, thiết kế công nghệ phù hợp để khai thác, sử dụng hiệu quả tài nguyên dầu khí trong nước.
COMPARATIVE BIOLOGY AND PREDATORY POTENTIAL OF Cryptolaemus montrouzieri ON MEALYBUGS
Authors: Allwin L. , Radhakrishnan V.
Published: September 2021

Comparative biology of Cryptolaemus montrouzieri on Maconellicoccus hirsutus and Pseudococcus citri revealed that it had completed its life cycle successfully on both species. The mean total developmental period (egg to pupa) was 18.1 days, when reared on P. citri and it was 20.9 days in M. hirsutus. The adults developed on P. citri had high fecundity 284.2 eggs / female and longevity 47.0 days than those developed on M. hirsutus. Analysis on the growth indices of C. montrouzieri showed more preference on P. citri with high suitability index of 2.51 than M. hirsutus (1.78). Among two life stages, adults of C. montrouzieri was more voracious and each adult consumed an average 258.7, 352.1 and 217.3 numbers on M. hirsutus while, it was 323.8, 715.6 and 328.6 number of eggs, nymphs and adults for P. citri, respectively. The grubs required 221.1, 55.1 and 36.6 numbers of M. hirsutus and 1079.0, 341.3 and 41.0 number of eggs, nymphs and adults of P. citri, respectively to complete life stages. Out of different instars of C. montrouzieri, third and fourth instars required around 92.1, 78.5 and 85.9 per cent and 88.9, 93.5 and 79.0 per cent of total eggs, nymphs and adults of P. citri and M. hirsutus consumed, respectively.
Histiocitosis de células de Langerhans: seguimiento de 5 años del caso y revisión sistemática de literatura.
Authors: Medina Ruiz Benanette , Arocho Lis , López Del-Valle Lydia M , Molina Negrón Damaris
Published: September 2021

La Histiocitosis de células de Langerhans (HCL), es una enfermedad rara, caracterizada por la proliferación clonal agresiva de células de Langerhans dendríticas de la médula ósea. La enfermedad crea lesiones osteolíticas en donde las manifestaciones orales usualmente están presentes. El objetivo de este reporte de caso es, presentar el seguimiento de cinco años de un caso diagnosticado en el 2014 y una revisión sistemática de literatura de las manifestaciones orales de HCL. Para la revisión sistemática, el argumento de búsqueda con palabras claves como HCL, histiocitosis X y manifestaciones orales, fueron conducidas en cinco bases de datos como PUBMED, LILACS, EBSCO, OVID y SCOPUS. Las manifestaciones orales más comunes son inflamación, enrojecimiento y pérdida de hueso en las áreas afectadas. Es importante mantener un seguimiento periódico en el consultorio dental de los casos de HCL en la población pediátrica. La HCL usualmente presenta manifestaciones orales que pueden ser un signo de diagnóstico temprano de esta condición, especialmente en la población pediátrica.
Manejo de secuelas de defectos del esmalte en paciente con Síndrome Muenke: Reporte de caso
Authors: Huamán Ochoa Anahí Francisca , Torres Ramos Gilmer , Medrano Hernández María , López Ramos Roxana Patricia
Published: September 2021

Resumen: El síndrome Muenke se caracteriza por retraso del desarrollo y pérdida auditiva neurosensorial. Personas que presentan síndromes podrían presentar defectos del desarrollo del esmalte. Sin embargo, en personas con síndrome Muenke no existe evidencia sobre la presencia y el manejo de las secuelas de estos defectos.   Objetivo: Describir el manejo de secuelas de los defectos del desarrollo del esmalte en dientes primarios con un procedimiento odontológico integral en sala de operaciones de paciente con síndrome Muenke. Caso Clínico: Paciente de 2 años de edad, sexo masculino, con diagnóstico sistémico de Síndrome Muenke y diagnóstico odontológico: fracturas post eruptivas del defecto del esmalte extensión I (< 1/3 del diente)  y II (de 1/3 a 2/3 del diente) en los dientes anteroinferiores y fracturas post eruptivas del defecto del esmalte extensión III (> 2/3 del diente) de los dientes 62 y 52. El manejo clínico de estas secuelas, realizadas en sala de operaciones, fueron con: carillas de resina compuestas fotopolimerizable que permitieron restaurar las fracturas post eruptivas del defecto del esmalte extensión I y II de los dientes antero inferiores; y en los dientes 62 y 52  con fracturas post eruptivas del defecto del esmalte extensión III fueron rehabilitadas con coronas de resina compuesta fotopolimerizable a mano alzada. Conclusión: El manejo de las secuelas de los defectos de desarrollo del esmalte, en paciente con Síndrome Muenke, se consideró clínicamente positivo; pues después de 6 meses los dientes tratados no presentaron dolor espontáneo, ni se observó fistulas o absceso, ni movilidad dentaria.
A favor de la democratización del conocimiento científico para el logro de los objetivos de desarrollo sostenible
Authors: Niño Téllez Ana Lorena , Castillo Mayorga Olga Rocio
Published: September 2021

Los Objetivos de Desarrollo Sostenible (ODS), también conocidos como Objetivos Mundiales, son un llamado universal a la adopción de medidas para poner fin a la pobreza, proteger el planeta y garantizar que todas las personas gocen de paz y prosperidad(UNDP-Programa de las Naciones Unidas para el Desarrollo, 2019a); 17 objetivos transversales orientados a los países que los adoptan, en el cumplimiento de las metas para lograrlos.
Determinación del flujo salivar en niños uruguayos portadores de HIV
Authors: Alvarez Loureiro Licet , L Hermida , A Fabruccini , G Suárez , M Ourens , E Gutiérrez
Published: September 2021

La mayoría de niños infectados por el virus de la inmunodeficiencia humana (VIH) presentan, dentro de sus primeros signos de enfermedad, manifestaciones orales. Uno de los factores a considerar es la disminución del flujo salival producido por infiltración glandular por el propio virus o como efecto secundario a la toma de medicación antiretroviral. Objetivo: Determinar el flujo salival en niños uruguayos portadores de VIH, que asisten al Centro Nacional de Referencia VIH SIDA del Centro Hospitalario Pereira Rossell, (CHPR) en Montevideo-Uruguay. Material y métodos: Se realizó un estudio descriptivo cuantitativo analítico de casos y controles. Se incluyeron todos los pacientes portadores de VIH que asisten al Centro Nacional de Referencia (CHPR) y los pacientes del grupo control eran usuarios del mismo Hospital, con similares condiciones socio-económicas y sanos desde el punto de vista general. Se realizó el recuento de flujo salival. Los niños del grupo de estudio se dividieron a su vez en dos grupos, según su adherencia al tratamiento antirretroviral, que era calificada en buena o mala. Se estudiaron también otros parámetros como hipertrofia parotídea y actividad de caries. Resultados: Se encontró diferencia estadísticamente significativa entre los niños del grupo de estudio y grupo control en relación a flujo salival (p= 0,0002), independiente de la adherencia al tratamiento antiretroviral.
Descripción del patrón y el recorrido de la apertura mandibular en niños con dentición mixta
Authors: Ramìrez S , Espinosa I , Muñoz G
Published: September 2021

Introducción: El recorrido de la apertura mandibular y las desviaciones que se presentan al abrir la boca, pueden ser un parámetro excelente para detectar de manera oportuna cualquier anomalía a nivel de del complejo temporomandibular.
El recorrido normal de la apertura mandibular en el adulto se encuentra entre los 53 y los 58 mm, con un promedio de 40 mm, un niño a partir de los 7 años puede lograr estos promedios de apertura mandibular. Solo el 1.2% de los adultos jóvenes abren menos de 40 mm, por lo tanto una apertura mandibular menor puede ser calificada como restringida de acuerdo a la edad y la talla del paciente.
Con el objetivo de determinar el patrón y el recorrido de la apertura mandibular con un método de diagnóstico validado, en un estudio observacional, descriptivo, se incluyeron 139 niños sanos con dentición mixta completa de 8 a 12 años de edad. Los resultados demostraron que el 30.9% de los niños presentó un patrón de apertura mandibular alterado, siendo la desviación mandibular izquierda corregida la más frecuente (16.5%), la apertura mandibularl promedio fue de 50±4.77mm, y las lateralidades; derecha 8.3±3,1 mm, y la izquierda 8.45±3.00mm. Lo cual permite concluir que la apertura mandibular en la dentición mixta, se encuentra dentro del recorrido descrito para los adultos en la literatura, con un porcentaje considerable de alteración en el patrón de apertura mandibular, lo cual puede ser considerado uno de los primeros signos de alteración en la función del sistema Temporomandibular.
¿Porqué el trauma em la dentición decídua es importante?
Authors: Turolla Wanderley Márcia , Bonini Gabriela , Cordesi Thais , Vargas-Machuca Monica Valdivieso , Martinez Maria Gabriela , Cortese Silvina G.
Published: September 2021

El trauma de la dentición caduca puede causar un impacto físico, emocional y psicológico en los niños de cualquier edad, sin embargo, muchos acaban por no atribuirle la importancia adecuada. Teniendo en cuenta que a los 2 años ya se está formando el diente permanente, el primer aspecto que debe ser relevante es el impacto que puede causar en el diente permanente. Los niños ponen a prueba sus límites y muchas veces pueden sufrir traumas que son difíciles de prevenir, pero hay algunas precauciones que se pueden tomar para evitar estos traumas. Este trabajo destaca la importancia de los traumatismos en la dentición decidua para aclarar dudas sobre las diferentes secuelas y sus tratamientos, a partir de los testimonios de los profesionales presentes en el 17º Congreso de la Academia Latinoamericana de Odontopediatría y 6º Congreso de la APO, 2014. Para evaluar el tratamiento y las secuelas en el diente permanente, se debe valorar el tipo de traumatismo, la edad del niño, la evaluación clínica y radiográfica, y finalmente el seguimiento hasta la erupción del diente permanente.
Enseñanza de Cariologia en el currículo de pregrado - Experiencia Latinoamericana
Authors: De Almeida Rodrigues Jonas , Lara Juan Sebastián , Argentieri Ángela , Zillmann Geerdts Gisela , Álvarez Licet , Loayza Susana , González Julio , Guerra María Elena , Martínez María Gabriela
Published: September 2021

La caries dental continua siendo una enfermedad que afecta a millones de personas a nivel mundial (1). En este sentido, es de suma importancia la creación de currículos de Cariología basados en la mejores evidencias científicas disponibles, dirigidos a estudiantes de odontología como futuros odontólogos y responsables por la salud oral de las poblaciones. Algunas iniciativas han sido desarrolladas con el fin de conocer la forma de enseñanza de Cariología en diferentes facultades del mundo e incentivar la creación de consensos que logren una educación en esta área mejor estructurada e unificada (27). Sin embargo, y a pesar de que dichas iniciativas han sido desarrolladas también en América Latina, no se conoce con amplitud la forma de enseñanza de Cariologia así como tampoco existen consensos en los currículos en la región. De esta manera, durante el 17º Congreso de la Asociación Latinoamericana de Odontopediatria ALOP en São Paulo, Brasil, fue realizado el primer encuentro de profesores de Odontopediatría de los países Latinoamericanos sobre la enseñanza de Cariología en el currículo de pregrado. La experiencia y conclusiones son relatadas en el presente documento.