bluuebunny/crossref_metadata_2025 huggingface dataset:
From Water Oxidation to Reduction: Homologous Ni–Co Based Nanowires as Complementary Water Splitting Electrocatalysts
Authors: Peng Zheng , Jia Dingsi , Al‐Enizi Abdullah M. , Elzatahry Ahmed A. , Zheng Gengfeng
Published: February 2015

A homologous Ni–Co based nanowire system, consisting of both nickel cobalt oxide and nickel cobalt sulfide nanowires, is developed for efficient, complementary water splitting. The spinel‐type nickel cobalt oxide (NiCo2O4) nanowires are hydrothermally synthesized and can serve as an excellent oxygen evolution reaction catalyst. Subsequent sulfurization of the NiCo2O4 nanowires leads to the formation of pyrite‐type nickel cobalt sulfide (Ni0.33Co0.67S2) nanowires. Due to the 1D nanowire morphology and enhanced charge transport capability, the Ni0.33Co0.67S2 nanowires function as an efficient, stable, and robust nonnoble metal electrocatalyst for hydrogen evolution reaction (HER), substantially exceeding CoS2 or NiS2 nanostructures synthesized under similar methods. The Ni0.33Co0.67S2 nanowires exhibit low onset potential of −65, −39, and −50 mV versus reversible hydrogen electrode, Tafel slopes of 44, 68, and 118 mV dec−1 at acidic, neutral, and basic conditions, respectively, and excellent stability, comparable to the best reported non‐noble metal‐based HER catalysts. Furthermore, the homologous Ni0.33Co0.67S2 nanowires and NiCo2O4 nanowires are assembled into an all‐nanowire based water splitting electrolyzer with a current density of 5 mA cm−2 at a voltage as 1.65 V, thus suggesting a unique homologous, earth abundant material system for water splitting.
Bubble generation rules in microfluidic devices with microsieve array as dispersion medium
Authors: Zheng Chen , Zhao Bochao , Wang Kai , Luo Guangsheng
Published: February 2015

Microfluidic devices with microsieve array as the dispersion medium have been well recognized. However, few studies have been made on gas‐liquid two‐phase flow in microsieve dispersion devices. The bubble generation rules with single‐pore, radial‐array pores, axial‐array pores, and square‐array pores were systematically investigated. The rules of pore activation have been suggested by considering the capillary force, flow resistances of both dispersed phase and continuous phase. An empirical equation and a theoretical equation to predict the activation of pores in microfluidic devices were developed. An equation to correlate the average bubble diameter with parameter of channel structure, phase ratio, and Ca number of continuous phase was also developed. The strategy of design and scaling up for microsieve devices is proposed. Meanwhile, a device with dual‐size pores according to the rules derived is designed. This device achieved much better dispersion performance. © 2015 American Institute of Chemical Engineers AIChE J, 61: 1663–1676, 2015
The role of wall deposition and re‐entrainment in swirl spray dryers
Authors: Francia Víctor , Martín Luis , Bayly Andrew E. , Simmons Mark J. H.
Published: February 2015

A new experimental method is outlined to study fouling in spray dryers and similar devices. In essence, it makes the deposits traceable so that one can quantify the material that comes off the walls, how long it remains there and how the deposits agglomerate with particles in the air. This paper investigates a countercurrent swirl spray dryer of detergent and provides sound evidence that fouling is a dynamic process: clusters form and break at the walls renewing an active layer of deposits. Remarkably, the wall generates >20% of the product and most of the large granules, and increases drastically the residence time of the powder. The assumptions of current numerical models are clearly invalid (i.e. particles rebound at the wall or deposit indefinitely). Several re‐entrainment mechanisms and their times scales are identified in this work, and accordingly, a new general framework to describe fouling in spray dryers is proposed. © 2015 American Institute of Chemical Engineers AIChE J, 61: 1804–1821, 2015
A rapid paper‐based test for quantifying sickle hemoglobin in blood samples from patients with sickle cell disease
Authors: Piety Nathaniel Z. , Yang Xiaoxi , Lezzar Dalia , George Alex , Shevkoplyas Sergey S.
Published: February 2015

Quantification of sickle hemoglobin (HbS) in patients with sickle cell disease (SCD) undergoing hydroxyurea or chronic transfusion therapy is essential to monitoring the effectiveness of these therapies. The clinical monitoring of %HbS using conventional laboratory methods is limited by high per‐test costs and long turnaround times usually associated with these methods. Here we demonstrate a simple, rapid, inexpensive paper‐based assay capable of quantifying %HbS in blood samples from patients with SCD. A 20 μL droplet of whole blood and hemoglobin solubility buffer was deposited on chromatography paper. The relative color intensities of regions of the resulting blood stain, determined by automated image analysis, are used to estimate %HbS. We compared the paper‐based assay with hemoglobin electrophoresis (comparison method) using blood samples from 88 subjects. The test shows high correlation (R2 = 0.86) and strong agreement (standard deviation of difference = 7%HbS) with conventional Hb electrophoresis measurement of %HbS, and closely approximates clinically predicted change in %HbS with transfusion therapy (mean difference 2.6%HbS, n = 5). The paper‐based assay can be completed in less than 35 min and has a per‐test cost less than $0.25. The assay is accurate across a wide range of HbS levels (10–97%) and hemoglobin concentrations (5.6–12.9 g/dL) and is unaffected by high levels of HbF (up to 80.6%). This study demonstrates the feasibility of the paper‐based %HbS assay. The paper‐based test could improve clinical care for SCD, particularly in resource‐limited settings, by enabling more rapid and less expensive %HbS monitoring. Am. J. Hematol. 90:478–482, 2015. © 2015 Wiley Periodicals, Inc.
Spatially Resolved Quantification of Gadolinium(III)‐Based Magnetic Resonance Agents in Tissue by MALDI Imaging Mass Spectrometry after In Vivo MRI
Authors: Aichler Michaela , Huber Katharina , Schilling Franz , Lohöfer Fabian , Kosanke Katja , Meier Reinhard , Rummeny Ernst J. , Walch Axel , Wildgruber Moritz
Published: February 2015

Gadolinium(III)‐based contrast agents improve the sensitivity and specificity of magnetic resonance imaging (MRI), especially when targeted contrast agents are applied. Because of nonlinear correlation between the contrast agent concentration in tissue and the MRI signal obtained in vivo, quantification of certain biological or pathophysiological processes by MRI remains a challenge. Up to now, no technology has been able to provide a spatially resolved quantification of MRI agents directly within the tissue, which would allow a more precise verification of in vivo imaging results. MALDI imaging mass spectrometry for spatially resolved in situ quantification of gadolinium(III) agents, in correlation to in vivo MRI, were evaluated. Enhanced kinetics of Gadofluorine M were determined dynamically over time in a mouse model of myocardial infarction. MALDI imaging was able to corroborate the in vivo imaging MRI signals and enabled in situ quantification of the gadolinium probe with high spatial resolution.
Radical CH Arylation of the BODIPY Core with Aryldiazonium Salts: Synthesis of Highly Fluorescent Red‐Shifted Dyes
Authors: Verbelen Bram , Boodts Stijn , Hofkens Johan , Boens Noël , Dehaen Wim
Published: February 2015

We describe herein the first radical CH arylation of BODIPY dyes. This novel, general, one‐step synthetic procedure uses ferrocene to generate aryl radical species from aryldiazonium salts and allows the straightforward synthesis of brightly fluorescent (Φ>0.85) 3,5‐diarylated and 3‐monoarylated boron dipyrrins in up to 86 % yield for a broad range of aryl substituents. In this way, new and complex dyes with red‐shifted spectra can be easily prepared.
Photoswitching the Cytotoxic Properties of Platinum(II) Compounds
Authors: Presa Andreu , Brissos Rosa F. , Caballero Ana Belén , Borilovic Ivana , Korrodi‐Gregório Luís , Pérez‐Tomás Ricardo , Roubeau Olivier , Gamez Patrick
Published: February 2015

The photoactivation of potential anticancer metal complexes is a hot topic of current research as it may lead to the development of more selective drugs. Photoactivated chemotherapy (PACT) with coordination compounds is usually based on a (photo)chemical reaction taking place at the metal center. Herein, a new strategy is exploited that consists of “photomodifying” a ligand coordinated to metal ions. Platinum(II) complexes from photoswitchable 1,2‐dithienylethene‐containing ligands have been prepared, which exhibit two interconvertible photoisomeric forms that present distinct DNA‐interacting properties and cytotoxic behaviors.
Effect of aliphatic diacyl adipic dihydrazides on the crystallization of poly(lactic acid)
Authors: Qi Zhongfei , Yang Yong , Xiong Zhu , Deng Jun , Zhang Ruoyu , Zhu Jin
Published: February 2015

A series of aliphatic diacyl adipic dihydrazides (ADHs) with different alkyl moieties were synthesized by the reaction between adipic dihydrazide and acyl chloride. Then these ADHs were solution blended with PLA respectively and were evaluated as nucleating agents. Through the investigation of nonisothermal and isothermal crystallization, it was found that both the crystallization rate and the crystallinity of PLA could be enhanced by adding only 1 wt % of ADHs. Especially for ADH‐Oc (ADH‐Octyl), the crystallization rate of PLA increased about 4 times at 105°C. Optical morphology showed that and the size of PLA spherulites decreased and the nucleation density increased with the existence of ADH‐Oc. Meanwhile, the crystal structure of PLA were not discerniblly affected after the addition of ADHs as found by wide‐angle X‐ray diffraction. Thus, this study suggested these ADHs compounds are simple and potential nucleating agents to enhance crystallization ability of PLA. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42028.
Influence of Intracellular Zinc on Cultures of Rat Cardiac Neural Crest Cells
Authors: Yang Hsunhui , Keen Carl L. , Lanoue Louise
Published: February 2015

BACKGROUND

Developmental zinc (Zn) deficiency increases the incidence of heart anomalies in rat fetuses, in regions and structures derived from the outflow tract. Given that the development of the outflow tract requires the presence of cardiac neural crest cells (cNCC), we speculated that Zn deficiency selectively kills cNCC and could lead to heart malformations.

METHODS

Cardiac NCC were isolated from E10.5 rat embryos and cultured in control media (CTRL), media containing 3 μM of the cell permeable metal chelator N, N, N′, N′‐tetrakis (2‐pyridylmethyl) ethylene diamine (TPEN), or in TPEN‐treated media supplemented with 3 μM Zn (TPEN + Zn). Cardiac NCC were collected after 6, 8, and 24 h of treatment to assess cell viability, proliferation, and apoptosis.

RESULTS

The addition of TPEN to the culture media reduced free intracellular Zn pools and cell viability as assessed by low ATP production, compared to cells grown in control or Zn‐supplemented media. There was an accumulation of reactive oxygen species, a release of mitochondrial cytochrome c into the cytoplasm, and an increased cellular expression of active caspase‐3 in TPEN‐treated cNCC compared to cNCC cultured in CTRL or TPEN + Zn media.

CONCLUSION

Zn deficiency can result in oxidative stress in cNCC, and subsequent decreases in their population and metabolic activity. These data support the concept that Zn deficiency associated developmental heart defects may arise in part as a consequence of altered cNCC metabolism
PMCA4 (ATP2B4) mutation in familial spastic paraplegia causes delay in intracellular calcium extrusion
Authors: Ho Philip Wing‐Lok , Pang Shirley Yin‐Yu , Li Miaoxin , Tse Zero Ho‐Man , Kung Michelle Hiu‐Wai , Sham Pak‐Chung , Ho Shu‐Leong
Published: February 2015

Background

Familial spastic paraplegia (FSP) is a heterogeneous group of disorders characterized primarily by progressive lower limb spasticity and weakness. More than 50 disease loci have been described with different modes of inheritance. Recently, we described a novel missense mutation (c.803G>A, p.R268Q) in the plasma membrane calcium ATPase (PMCA4, or ATP2B4) gene in a Chinese family with autosomal dominant FSP. Further to this finding, here we describe the functional effect of this mutation.

Methods

As PMCA4 removes cytosolic calcium, we measured transient changes and the time‐dependent decay of cytosolic calcium level as visualized by using fura‐2 fluorescent dye with confocal microscopy in human SH‐SY5Y neuroblastoma cells overexpressing either wild‐type or R268Q mutant PMCA4.

Results

Overexpressing both wild‐type and R268Q PMCA4 significantly reduced maximum calcium surge after KCl‐induced depolarization as compared with vector control cells. However, cells overexpressing mutant PMCA4 protein demonstrated significantly higher level of calcium surge when compared with wild‐type. Furthermore, the steady‐state cytosolic calcium concentration in these mutant cells remained markedly higher than the wild‐type after SERCA inhibition by thapsigargin.

Conclusion

Our result showed that p.R268Q mutation in PMCA4 resulted in functional changes in calcium homeostasis in human neuronal cells. This suggests that calcium dysregulation may be associated with the pathogenesis of FSP.
A 3D in situ cell counter reveals that breast tumor cell (MDA‐MB‐231) proliferation rate is reduced by the collagen matrix density
Authors: Kim Beum Jun , Zhao Shuting , Bunaciu Rodica P. , Yen Andrew , Wu Mingming
Published: February 2015

Many cell types require the biophysical and biochemical cues within the 3D extracellular matrix (ECM) to exhibit their true physiologically relevant behavior. As a result, cell culture platforms have been evolving from traditional 2D petridish plates into 3D biomatrices, and there is a need for developing analytic tools to characterize 3D cell culture. The existing cell counting method, using a hemocytometer or coulter counter, requires that cells are suspended in fluids prior to counting. This poses a challenge for 3D cell culture as cells are embedded in a 3D biomatrix. We use a facile 3D cell counting method that overcomes this limitation and allows for in situ cell counting in a 3D cell culture using equipment that is commonly available in a biology lab. Using a breast tumor cell line, MDA‐MB‐231, as a model system, we demonstrated that MDA‐MB‐231 cells (1) grow slower within a 3D collagen matrix than on a 2D substrate for an extended growth time (a week) with a comparable, initial cell‐to‐cell distance, (2) their cell growth rate decreases with the increase of collagen concentration, showing a linear growth rate rather than an exponential growth rate. Further work using flow cytometry showed that the observed growth rate reduction was consistent with the retardation of the transition to S (synthesis) phase in the cell cycle. This work demonstrates the validity of the 3D cell counting method and the importance of cell–ECM interactions in cell proliferation. © 2015 American Institute of Chemical Engineers Biotechnol. Prog., 31:990–996, 2015
From osmotic second virial coefficient (B22) to phase behavior of a monoclonal antibody
Authors: Rakel Natalie , Bauer Katharina Christin , Galm Lara , Hubbuch Juergen
Published: February 2015

Antibodies are complex macromolecules and their phase behavior as well as interactions within different solvents and precipitants are still not understood. To shed some light into the processes on a molecular dimension, the occurring self‐interactions between antibody molecules were analyzed by means of the osmotic second virial coefficient (B22). The determined B22 follows qualitatively the phenomenological Hofmeister series describing the aggregation probability of antibodies for the various solvent compositions. However, a direct correlation between crystallization probability and B22 in form of a crystallization slot does not seem to be feasible for antibodies since the phase behavior is strongly dependent on their anisotropy. Kinetic parameters have to be taken into account due to the molecular size and complexity of the molecules. This is confirmed by a comparison of experimental data with a theoretical phase diagram. On the other hand the solubility is thermodynamically driven and therefore the B22 could be used to establish a universal solubility line for the monoclonal antibody mAb04c and different solvent compositions by using thermodynamic models. © 2015 American Institute of Chemical Engineers Biotechnol. Prog., 31:438–451, 2015
Microbial Transglutaminase and c‐myc‐Tag: A Strong Couple for the Functionalization of Antibody‐Like Protein Scaffolds from Discovery Platforms
Authors: Dennler Patrick , Bailey Laura K. , Spycher Philipp R. , Schibli Roger , Fischer Eliane
Published: February 2015

Antibody‐like proteins selected from discovery platforms are preferentially functionalized by site‐specific modification as this approach preserves the binding abilities and allows a side‐by‐side comparison of multiple conjugates. Here we present an enzymatic bioconjugation platform that targets the c‐myc‐tag peptide sequence (EQKLISEEDL) as a handle for the site‐specific modification of antibody‐like proteins. Microbial transglutaminase (MTGase) was exploited to form a stable isopeptide bond between the glutamine on the c‐myc‐tag and various primary‐amine‐functionalized substrates. We attached eight different functionalities to a c‐myc‐tagged antibody fragment and used these bioconjugates for downstream applications such as protein multimerization, immobilization on surfaces, fluorescence microscopy, fluorescence‐activated cell sorting, and in vivo nuclear imaging. The results demonstrate the versatility of our conjugation strategy for transforming a c‐myc‐tagged protein into any desired probe.
NAF‐1 antagonizes starvation‐induced autophagy through AMPK signaling pathway in cardiomyocytes
Authors: Du Xiaohong , Xiao Renjie , Xiao Fan , Chen Yong , Hua Fuzhou , Yu Shuchun , Xu Guohai
Published: February 2015

NAF‐1 (nutrient‐deprivation autophagy factor‐1), an autophagy‐related gene‐related (ATG) protein, has been implicated in the autophagic pro‐survival response. However, its role in autophagy has not been examined in the cardiomyocytes. In this study, we found that nutritional stress (NS) induced by glucose deprivation strongly induced autophagy in cultured neonatal rat cardiomyocytes, which was associated with NAF‐1 down‐regulation in cardiomyocytes under NS conditions. Furthermore, we demonstrate that ectopic expression of NAF‐1 was sufficient to inhibit autophagy in cardiomyocytes under glucose deprivation conditions. Moreover, results of the co‐immunoprecipitation assay indicate that NAF‐1 antagonized autophagy by promoting the interaction between Beclin1 and Bcl‐2 in NS‐induced cardiomyocytes. Importantly, our results indicate that overexpression of NAF‐1 significantly inhibited AMPK activity and protected cardiomyocytes from NS‐induced cell death. Taken together, these data show that ectopic expression of NAF‐1 antagonizes the degree of autophagy in cardiomyocytes and enhances cell survival during starvation conditions.
Ultrasound‐ and Microwave‐Assisted Preparation of Lead‐Free Palladium Catalysts: Effects on the Kinetics of Diphenylacetylene Semi‐Hydrogenation
Authors: Wu Zhilin , Cherkasov Nikolay , Cravotto Giancarlo , Borretto Emily , Ibhadon Alex O. , Medlock Jonathan , Bonrath Werner
Published: February 2015

The effect of environmentally benign enabling technologies such as ultrasound and microwaves on the preparation of the lead‐free Pd catalyst has been studied. A one‐pot method of the catalyst preparation using ultrasound‐assisted dispersion of palladium acetate in the presence of the surfactant/capping agent and boehmite support produced the catalyst containing Pd nanoparticles and reduced the number of pores larger than 4 nm in the boehmite support. This catalyst demonstrated higher activity and selectivity. The comparison of kinetic parameters for diphenylacetylene hydrogenation showed that the catalyst obtained by using the one‐pot method was seven times as active as a commercial Lindlar catalyst and selectivity towards Z‐stilbene was high. Our work also illustrated that highly selective Pd/boehmite catalysts can be prepared through ultrasound‐assisted dispersion and microwave‐assisted reduction in water under hydrogen pressure without any surfactant.
Self‐Assembly and Gelation of Poly(aryl ether) Dendrons Containing Hydrazide Units: Factors Controlling the Formation of Helical Structures
Authors: Malakar Partha , Prasad Edamana
Published: February 2015

Self‐assembly of AB2 and AB3 type low molecular weight poly(aryl ether) dendrons that contain hydrazide units were used to investigate mechanistic aspects of helical structure formation during self‐assembly. The results suggest that there are three important aspects that control helical structure formation in such systems with acyl hydrazide/hydrazone linkage: i) J‐type aggregation, ii) the hydrogen‐bond donor/acceptor ability of the solvent, and iii) the dielectric constant of the solvent. The monomer units self‐assemble to form dimer structures through hydrogen‐bonding and further assembly of the hydrogen‐bonded dimers leads to macroscopic chirality in the present case. Dimer formation was confirmed by NMR spectroscopy and by mass spectrometry. The self‐assembly in the system was driven by hydrogen‐bonding and π–π stacking interactions. The morphology of the aggregates formed was examined by scanning electron microscopy, and the analysis suggests that aprotic solvent systems facilitate helical fibre formation, whereas introduction of protic solvents results in the formation of flat ribbons. This detailed mechanistic study suggests that the self‐assembly follows a nucleation–elongation model to form helical structures, rather than the isodesmic model.
Highly Selective Hydrothiolation of Unsaturated Organosilicon Compounds Catalyzed by Scandium(III) Triflate
Authors: Kuciński Krzysztof , Pawluć Piotr , Marciniec Bogdan , Hreczycho Grzegorz
Published: February 2015

The first use of a Lewis acid catalyst in the addition reaction of both aromatic and aliphatic thiols to unsaturated organosilicon compounds is reported. In catalytic tests, scandium(III) triflate demonstrates high catalytic activity in this process. Under mild conditions (25 °C, room temperature, 1–10 h) a number of thioether‐functionalized organosilicon species are obtained with appreciable selectivity. This study constitutes the first example of allylsilane hydrothiolation that gives the Markovnikov regioisomer as the main product. Ethynylsilanes are also successfully used in the hydrothiolation reaction in the presence of Sc(OTf)3.
Direct CH Amidation of Benzoic Acids to Introduce meta‐ and para‐Amino Groups by Tandem Decarboxylation
Authors: Lee Donggun , Chang Sukbok
Published: February 2015

The Ir‐catalyzed mild CH amidation of benzoic acids with sulfonyl azides was developed to give reactions with high efficiency and functional‐group compatibility. Subsequent protodecarboxylation of ortho‐amidated benzoic acid products afforded meta‐ or para‐substituted (N‐sulfonyl)aniline derivatives, the latter being inaccessible by other CH functionalization approaches. The decarboxylation step was compatible with the amidation conditions, enabling a convenient one‐pot, two‐step process.
An NHC‐Catalyzed In Situ Activation Strategy to β‐Functionalize Saturated Carboxylic Acid: An Enantioselective Formal [3+2] Annulation for Spirocyclic Oxindolo‐γ‐butyrolactones
Authors: Xie Yuanwei , Yu Chenxia , Li Tuanjie , Tu Shujiang , Yao Changsheng
Published: February 2015

An in situ NHC‐catalyzed activation strategy to β‐functionalize saturated carboxylic acid was developed. This asymmetric formal [3+2] annulation could deliver spirocyclic oxindolo‐γ‐butyrolactones from saturated carboxylic acid and isatin in good yields with high to excellent enantioselectivities. The easy availability of the starting materials, direct installation of functional units at unreactive carbon atom and the convergent assembly make this protocol attractive in the field of organic synthesis.
ChemInform Abstract: Structure of β‐AgGaO2; Ternary I—III—VI2 Oxide Semiconductor with a Wurtzite‐Derived Structure.
Authors: Nagatani Hiraku , Suzuki Issei , Kita Masao , Tanaka Masahiko , Katsuya Yoshio , Sakata Osami , Omata Takahisa
Published: February 2015

β‐AgGaO2 is prepared by Na+/Ag+ ion exchange of β‐NaGaO2 precursor in a mixed molten salt of AgNO3 and KNO3 (200 °C, 12 h).
ChemInform Abstract: Studies on the Thermal Stability of BiCuSeO.
Authors: Barreteau Celine , Berardan David , Dragoe Nita
Published: February 2015

Thermoelectric p‐type Pb‐free polycrystalline BiCuSeO is prepared by a two‐step solid state reaction using stoichiometric amounts of Bi2O3, Bi, Cu, and Se (silica tubes, 700 °C, 1 week) followed by densification via pressurized spark plasma sintering under Ar (675 °C, 10 min, 100 MPa).
ChemInform Abstract: Nuclear and Magnetic Supercells in the Multiferroic Candidate: Pb3TeMn3P2O14.
Authors: Silverstein Harlyn J. , Huq Ashfia , Lee Minseong , Choi Eun Sang , Zhou Haidong , Wiebe Christopher R.
Published: February 2015

The crystal and magnetic structures of the title compound are determined by synchrotron X‐ray and neutron diffraction.
ChemInform Abstract: Synthesis and Performance of Li4Ti5O12 Anode Materials Using the PVP‐Assisted Combustion Method.
Authors: Chang Long‐Jiao , Luo Shao‐Hua , Zhang Hai‐Liang , Qi Xi‐Wei , Wang Zhi‐Yuan , Liu Yan‐Guo , Zhai Yu‐Chun
Published: February 2015

Li4Ti5O12 is prepared by a gel‐combustion method using polyvinylpyrrolidone as chelating agent and fuel, TiO2, and Li(OAc) in H2O at pH 3 (100 °C) before igniting the dried gel and subsequent calcination in air (800 °C, 8 h).
ChemInform Abstract: Borate Fluoride and Fluoroborate in Alkali‐Metal Borate Prepared by an Open High‐Temperature Solution Method.
Authors: Wu Hongping , Yu Hongwei , Bian Qiang , Yang Zhihua , Han Shujuan , Pan Shilie
Published: February 2015

Single crystals of the new compounds (V) and (VIII) are prepared by a high temperature solution flux method.
ChemInform Abstract: Synthesis of New Ga7Ge3Te11—One‐Dimensional Phase in Ga—Ge—Te Ternary System: Crystal Structure and Physical Properties.
Authors: Drasar Cestmir , Cisarova Ivana , Kucek Vladimir , Benes Ludvik , Prokleska Jan , Kratochvilova Marie
Published: February 2015

Polycrystalline samples of compositions between Ga8Ge2Te11 and Ga6Ge4Te11 are prepared from the elements (evacuated quartz tubes, 1170 K, 2 h) from which single crystals are grown by transport in a small temperature gradient (average 960 K).
ChemInform Abstract: Chiral Room Temperature Ionic Liquids as Enantioselective Promoters for the Asymmetric Aldol Reaction.
Authors: Gonzalez Laura , Escorihuela Jorge , Altava Belen , Burguete M. Isabel , Luis Santiago V.
Published: February 2015

Chiral ionic liquids (CIL), derived from natural amino acids, are used as reaction media for direct asymmetric aldol reactions catalyzed by L‐proline.
ChemInform Abstract: Enantioselective Copper Catalyzed C—H Insertion Reaction of 2‐Sulfonyl‐2‐diazoacetamides to Form γ‐Lactams.
Authors: Clarke Leslie Ann , Ring Aoife , Ford Alan , Sinha Abhijeet S. , Lawrence Simon E. , Maguire Anita R.
Published: February 2015

The first example of asymmetric Cu‐catalyzed intramolecular C—H insertion reaction of title compounds (I) is described.
ChemInform Abstract: Water‐Promoted Ring‐Opening Reactions of N‐Substituted Saccharins and Phthalimides by Amines.
Authors: Bai Lisha , Zhang Xuan , Ma Ning
Published: February 2015

Various o‐sulfamoyl benzamides and N,N′‐disubstituted phthalamides are prepared under mild reaction conditions using water as the reaction medium.
ChemInform Abstract: Supported Palladium Oxide Nanoparticles in SBA‐15 as a Heterogeneous Catalyst for the Aerobic Oxidation of Alcohols.
Authors: Atashin Hassan , Malakooti Reihaneh
Published: February 2015

The title heterogeneous catalyst allows the efficient conversion of primary and secondary alcohols into the corresponding aldehydes and ketones under oxygen atmosphere.
ChemInform Abstract: Methandiide as a Non‐innocent Ligand in Carbene Complexes: From the Electronic Structure to Bond Activation Reactions and Cooperative Catalysis.
Authors: Becker Julia , Modl Tanja , Gessner Viktoria H.
Published: February 2015

The synthesis of a ruthenium‐carbene complex based on a dilithio methandiide and its application in O—H‐ and H—H‐ bond activation reactions as well as in the catalytic transfer hydrogenation for the reduction of acetophenone is described.
ChemInform Abstract: Efficient Cobalt‐Catalyzed C—N Cross‐Coupling Reaction Between Benzamide and Aryl Iodide in Water.
Authors: Tan Bryan Yong‐Hao , Teo Yong‐Chua
Published: February 2015

Under optimized conditions, a wide variety of N‐arylated benzamides (III) and (V) is obtained in good yields, in general.
ChemInform Abstract: Palladium‐Catalyzed Carbonylations of Aryl Bromides Using Paraformaldehyde: Synthesis of Aldehydes and Esters.
Authors: Natte Kishore , Dumrath Andreas , Neumann Helfried , Beller Matthias
Published: February 2015

The first successful application of readily available paraformaldehyde in a CO‐gas‐free synthetic protocol for palladium‐catalyzed carbonylations of aryl halides is reported.
ChemInform Abstract: Development of a Mild and Efficient Protocol for the Protection and O‐Alkylation of Allyl Alcohols.
Authors: Selvakumar Kodirajan , Prasath Lingam Kandapalam Arun , Luxmi Varma Rama Varma
Published: February 2015

The microwave‐assisted protection is found to proceed under clean and pyridine‐free conditions in shorter reaction time compared to the conventional method.
ChemInform Abstract: Aerobic Direct C—H Arylation of Nonbiased Olefins.
Authors: Gigant Nicolas , Baeckval Jan‐E.
Published: February 2015

A complex catalytic system is presented for the aerobic oxidative dehydrogenative cross‐coupling between olefins, arenes, perfluoroarenes, and heterocycles.
ChemInform Abstract: Palladium‐Catalyzed Cascade C—H Trifluoroethylation of Aryl Iodides and Heck Reaction: Efficient Synthesis of ortho‐Trifluoroethylstyrenes.
Authors: Zhang Hao , Chen Pinhong , Liu Guosheng
Published: February 2015

An efficient approach to the title compounds becomes possible under conditions A).
ChemInform Abstract: An Unprecedented Approach to the Gabriel Amine Synthesis Utilizing Tosylhydrazones as Alkylating Agents.
Authors: Yadav Arvind K. , Yadav Lal Dhar S.
Published: February 2015

A significant modification of the Gabriel amine synthesis is developed.
ChemInform Abstract: Base‐Free Chemoselective Transfer Hydrogenation of Nitroarenes to Anilines with Formic Acid as Hydrogen Source by a Reusable Heterogeneous Pd/ZrP Catalyst.
Authors: Tuteja Jaya , Nishimura Shun , Ebitani Kohki
Published: February 2015

The catalyst is recovered and reused in three additional cycles without loss of its activity.
ChemInform Abstract: Copper‐Catalyzed Three‐Component Azidotrifluoromethylation/Difunctionalization of Alkenes.
Authors: Yang Mingbo , Wang Wenlu , Liu Yin , Feng Lijie , Ju Xuexia
Published: February 2015

A novel three‐component strategy for the azidotrifluoromethylation of alkene is developed.
ChemInform Abstract: Catalytic Cleavage of Ether C—O Bonds by Pincer Iridium Complexes.
Authors: Haibach Michael C. , Lease Nicholas , Goldman Alan S.
Published: February 2015

Optimized conditions including the pincer complex shown allow the cleavage of substrates (I) and (III) to produce the corresponding phenol components, accompanied by olefins derived from the alkyl substituents R.
ChemInform Abstract: Enantioselective Hydrosilylation of Ketones Catalyzed by a Readily Accessible N‐Heterocyclic Carbene—Ir Complex at Room Temperature.
Authors: Shinohara Kanako , Kawabata Shun , Nakamura Hanako , Manabe Yoshiki , Sakaguchi Satoshi
Published: February 2015

Novel types of air‐stable Ir NHC‐complexes containing a hydroxy‐amide functionalized azolium ligand are developed and used as catalyst for the asymmetric hydrosilylation of ketones in the presence of (EtO)2MeSiH under mild reaction conditions.
ChemInform Abstract: Oxidative Cleavage of α‐Sulfonyl Ketones to Carboxylic Acids with Ce(NH4)2(NO3)6.
Authors: Chang Meng‐Yang , Tsai Chung‐Yu
Published: February 2015

A facile protocol using CAN and O2 as the co‐oxidant is developed for the oxidative cleavage of C—S and C—C bonds of α‐sulfonyl ketones to yield carboxylic acids.
ChemInform Abstract: Preparation of Highly Substituted (β‐Acylamino)acrylates via Iron‐Catalyzed Alkoxycarbonylation of N‐Vinylacetamides with Carbazates.
Authors: Ding Ran , Zhang Qiu‐Chi , Xu Yun‐He , Loh Teck‐Peng
Published: February 2015

The reaction proceeds with high diastereoselectivity and can be scaled up.
ChemInform Abstract: Combining Rhodium and Photoredox Catalysis for C—H Functionalizations of Arenes: Oxidative Heck Reactions with Visible Light.
Authors: Fabry David C. , Zoller Jochen , Raja Sadiya , Rueping Magnus
Published: February 2015

The title reactions, carried out under dual catalysis, render possible the preparation of various aryl amides with an olefin side chain in ortho position.
ChemInform Abstract: Conversion of N‐Benzyloxycarbonylamino‐ and N‐Tosylamino‐benzyl Phenylsulfones by Green Strecker Reactions to α‐Aminobenzyl Nitriles Using Potassium Hexacyanoferrate(II).
Authors: Hu Xiaochun , Li Rongzhi , Li Zheng
Published: February 2015

The introduced protocol has the advantages of using a nontoxic, nonvolatile and inexpensive cyanating agent, employing a simple work‐up procedure and producing high yields.
ChemInform Abstract: Zinc Chloride Catalyzed Ring Opening of N‐Arylsulfonyl Aziridines by Thioamides: A New Approach to the Synthesis of Amidines.
Authors: Hajibabaei Khadijeh , Zali‐Boeini Hassan
Published: February 2015

The method proceeds with similar efficiency as previously developed methods, but has an advantage of not requiring toxic or explosive reagents.
ChemInform Abstract: Gold(I)‐Catalyzed Direct Thioetherifications Using Allylic Alcohols: An Experimental and Computational Study.
Authors: Herkert Lorena , Green Samantha L. J. , Barker Graeme , Johnson David G. , Young Paul C. , Macgregor Stuart A. , Lee Ai‐Lan
Published: February 2015

A mild regioselective and stereoselective direct formal SN2′ thioetherification of allylic alcohols is developed.
ChemInform Abstract: Efficient One‐Pot Cross‐Coupling of Two Aryl Halides by Stannylation/Stille Reaction in Water under Microwave Irradiation.
Authors: Tan Xin , Zhou Zi Jie , Zhang Jia Xin , Duan Xin Hong
Published: February 2015

The synthetic value of this protocol is demonstrated by preparation of the boscalide intermediate (XIV).
ChemInform Abstract: Direct Carbocyclizations of Benzoic Acids: Catalyst‐Controlled Synthesis of Cyclic Ketones and the Development of Tandem aHH (acyl Heck‐Heck) Reactions.
Authors: Miles Kelsey C. , Le Chi , Stambuli James P.
Published: February 2015

A highly selective method for the cyclization of ortho‐allylated arylcarboxylates to exo‐methylene indanones or analogous 3‐methylindenones is developed.
ChemInform Abstract: Sterically Controlled Diels—Alder Cycloadditions: Rapid Entry into the Illudin Scaffold.
Authors: Stevens‐Cullinane Lars , Lucas Nigel T. , Hawkins Bill C.
Published: February 2015

Hoveyda—Grubbs catalyzed enyne ring‐closing metathesis produces the diene (II) in good yields.
ChemInform Abstract: A Three‐Component Reaction for the Synthesis of Diverse, Densely Substituted 2′,3′‐Dihydrospiro[indoline‐3,6′‐[1,3]oxazine]s.
Authors: Zhang Jing , Gao Hong , Sun Jing , Yan Chao‐Guo
Published: February 2015

A three‐component reaction of N‐arylaldimines with isatin and dialkylacetylene dicarboxylates is developed to yield diastereomeric mixtures of spirocyclic indoline‐oxazine derivatives.
ChemInform Abstract: Diastereo‐ and Enantioselective Construction of a Bispirooxindole Scaffold Containing a Tetrahydro‐β‐carboline Moiety Through an Organocatalytic Asymmetric Cascade Reaction.
Authors: Dai Wei , Lu Han , Li Xin , Shi Feng , Tu Shu‐Jiang
Published: February 2015

A three‐component cascade Michael/Pictet—Spengler reaction of isatins, isatin‐derived 3‐indolylmethanols, and 2‐aminomalonate in the presence of a BINOL‐phosphonic acid catalyst is developed to provide bisspirooxindoles with excellent diastereo‐ and enantioselectivities.
ChemInform Abstract: Synthetic Epoxy‐Mycolic Acids.
Authors: Al Kremawi Dakhil Z. , Al Dulayymi Juma'a R. , Baird Mark S.
Published: February 2015

Some single enantiomers of epoxy‐mycolic acids containing an α‐methyl‐trans‐alkene or a cis‐cyclopropane are synthesized.
ChemInform Abstract: Synthesis of Functionalized β‐Lactams and Pyrrolidine‐2,5‐diones Through a Metal‐Free Sequential Ugi‐4CR/Cyclization Reaction.
Authors: Ghabraie Elmira , Balalaie Saeed , Mehrparvar Saber , Rominger Frank
Published: February 2015

The 4‐component reaction affords intermediate N‐substituted 2‐alkynamides of type (V).
ChemInform Abstract: Regioselective Synthesis of Novel and Diverse Naphtho[1,2‐b]furan‐3‐carboxamides and Benzofuran‐3‐carboxamides by Cascade Formal [3 + 2] Cycloaddition.
Authors: Xia Likai , Lee Yong Rok
Published: February 2015

The title compounds (III) and (V) are efficiently obtained by In(OTf)3‐catalyzed formal cascade [3 + 2] cycloaddition of 1,4‐naphthoquinones or benzoquinones with β‐ketoamides.
ChemInform Abstract: Solvent‐Free Synthesis of 2‐Aminothiophene‐3‐carbonitrile Derivatives Using High‐Speed Vibration Milling.
Authors: Xu Fang , Li Yujin , Xu Fengshuang , Ye Qing , Han Liang , Gao Jianrong , Yu Wubin
Published: February 2015

A green and convenient method for the synthesis of the title thiophenecarbonitrile derivatives using a three‐component reaction under vibration milling is developed.
ChemInform Abstract: Studies on the Synthesis and Bioactivities of 4‐Amino Derivatives of Tetramic Acid.
Authors: Liu Yu‐Xiu , Zhao Hua‐Ping , Song Hai‐Bin , Gu Yu‐Cheng , Wang Qing‐Min
Published: February 2015

New derivatives (IIIa) and (IIId) exhibit good herbicidal activities against Arabidopsis thaliana and compound (VIIIb) shows relatively good antifungal activity against Alternaria solani and Botrytis cineria.
ChemInform Abstract: AcOH‐Mediated Dichloroimination of Indoles Using Chloramine‐B: A Facile Access to 2,3‐Functionalized Indolines.
Authors: Liu Xiaozu , Hu Qinghong , Yuan Zeli , Liu Peijun
Published: February 2015

Application of the described method to tryptamine (VI) affords pyrrolidinoindole (VII).
ChemInform Abstract: A Facile Synthesis of 2H‐Indazoles under Neat Conditions and Further Transformation into Aza‐γ‐Carboline Alkaloid Analogues in a Tandem One‐Pot Fashion.
Authors: Vidyacharan Shinde , Sagar A. , Chaitra N. C. , Sharada Duddu S.
Published: February 2015

An efficient and green protocol for the microwave‐promoted synthesis of indazoles via a consecutive formation of C—N and N—N bonds without any catalyst and solvent is described.
ChemInform Abstract: Efficient One‐Pot Solvent‐Free Synthesis of 1H‐Pyrazolo[1,2‐b]phthalazine‐5,10‐diones Catalyzed by Sulfonic Acid Functionalized Nanoporous Silica (SBA‐Pr‐SO3H).
Authors: Ziarani Ghodsi Mohammadi , Mohtasham Nina Hosseini , Badiei Alireza , Lashgari Negar
Published: February 2015

Sulfonic acid functionalized nanoporous silica SBA‐15 catalyzes the cyclocondensation reaction of phthalhydrazide, malononitrile, or ethyl cyanoacetate and aldehydes to afford the title species in a one‐pot manner.
ChemInform Abstract: Sequential Synthesis of Amino‐1,4‐naphthoquinone‐appended Triazoles and Triazole‐chromene Hybrids and Their Antimycobacterial Evaluation.
Authors: Devi Bala Balasubramanian , Muthusaravanan Sivasubramanian , Choon Tan Soo , Ashraf Ali Mohamed , Perumal Subbu
Published: February 2015

38 Title compounds of type (III) and (V) are prepared and screened for their in vitro activity against Mycobacterium tuberculosis H37Rv (MTB).
ChemInform Abstract: An Efficient One‐Pot Strategy for the Highly Regioselective Metal‐Free Synthesis of 1,4‐Disubstituted‐1,2,3‐triazoles.
Authors: Ali Akbar , Correa Arlene G. , Alves Diego , Zukerman‐Schpector Julio , Westermann Bernhard , Ferreira Marco A. B. , Paixao Marcio W.
Published: February 2015

The target products are obtained from various alkylidene malonitriles and aromatic azides.
ChemInform Abstract: Modular Synthesis of Bis‐ and Tris‐1,2,3‐triazoles by Permutable Sequential Azide—Aryne and Azide—Alkyne Cycloadditions.
Authors: Yoshida Suguru , Nonaka Takako , Morita Takamoto , Hosoya Takamitsu
Published: February 2015

Key of the described method is the efficient generation of arynes from ortho‐iodoaryl triflates, e.g. (I), bearing a base‐sensitive terminal alkyne moiety, which is achieved using trimethylsilylmethyl Grignard reagent.
ChemInform Abstract: A Convenient Eco‐Friendly System for the Synthesis of 5‐Sulfenyl Tetrazole Derivatives of Indoles and Pyrroles Employing CeCl3·7H2O in PEG‐400.
Authors: Fortes Margiani P. , Bassaco Mariana M. , Kaufman Teodoro S. , Silveira Claudio C.
Published: February 2015

A facile and efficient synthesis of 5‐sulfenyltetrazoles from thiocyanates derived from 1H‐indoles, and 1‐phenyl pyrroles under environmentally friendly conditions, is reported.
ChemInform Abstract: Catalytic 1,4‐Rhodium(III) Migration Enables 1,3‐Enynes to Function as One‐Carbon Oxidative Annulation Partners in C—H Functionalizations.
Authors: Burns David J. , Lam Hon Wai
Published: February 2015

An unexpected mode of oxidative annulation in Rh‐catalyzed C‐H functionalizations of arenes having hydroxy‐substituted functionalities with 1,3‐enynes containing allylic hydrogens cis to the alkynes is described.
ChemInform Abstract: Rhodium(III)‐Catalyzed Decarbonylative Coupling of Maleic Anhydrides with Alkynes.
Authors: Matsuda Takanori , Suzuki Kentaro
Published: February 2015

The coupling of diphenylacetylene (IIa) with the parent maleic anhydride and succinic anhydride derivatives fails.
ChemInform Abstract: Organocatalytic Cascade Reactions: Towards the Diversification of Hydroisochromenes and Chromenes Through Two Different Activation Modes.
Authors: Cruz Cruz David , Mose Rasmus , Villegas Gomez Clarisa , Torbensen Stine V. , Larsen Martin S. , Joergensen Karl Anker
Published: February 2015

Functionalized hydroisochromenes (III), (V) and chromenes (VII) are enantioselectively obtained by trienamine‐mediated [4+2]‐cycloaddition/nucleophilic ring‐closing or iminium‐ion/aminal‐mediated oxa‐Michael/Michael/nucleophilic ring‐closing reactions of 2‐nitroallylic alcohols (II).
ChemInform Abstract: An Efficient and Reusable Ionic Liquid Catalyst for the Synthesis of 14‐Aryl‐14H‐dibenzo[a,j]xanthenes under Solvent‐Free Conditions.
Authors: Zhu Anlian , Bai Shukun , Jin Wei , Liu Ruixia , Li Lingjun , Zhao Yang , Wang Jianji
Published: February 2015

Catalyst is recyclable and reusable at least 6 times.
ChemInform Abstract: Pd‐Mediated Multicomponent Synthesis of Highly Functionalized Pyridines and Consequential C—C Coupling Using Suzuki Reaction in One Pot: Their in vitro Evaluation as Potential Antibacterial Agents.
Authors: Srinivasula Reddy L. , Ram Reddy T. , Gangi Reddy N. C. , Mohan Reddy Bodireddy , Lingappa Y.
Published: February 2015

Some of the new compounds, (Vb), (Vg), (Vh), show good inhibition against the multi drug resistant gram‐negative bacterial strain Klebsiella pneumoniae (MTCC 109), nearly equivalent to that of reference drug chloramphenicol.
ChemInform Abstract: α‐Acryloylamidoalkyl Sulfones in a Synthetic Approach for the Preparation of 6‐Alkyltetrahydropyridin‐2‐ones.
Authors: Lucchetti Nicola , Lancianesi Stefano , Petrini Marino
Published: February 2015

α‐Acryloylamidoalkyl sulfones are converted with in situ generated allylzinc bromides to give a range of dienic products.
ChemInform Abstract: Oxidative Catalysis Using the Stoichiometric Oxidant as a Reagent: An Efficient Strategy for Single‐Electron‐Transfer‐Induced Tandem Anion—Radical Reactions.
Authors: Kafka Frantisek , Holan Martin , Hidasova Denisa , Pohl Radek , Cisarova Ivana , Klepetarova Blanka , Jahn Ullrich
Published: February 2015

Catalytic aza‐Michael and Michael addition reactions/radical cyclizations/oxygenation reactions which incorporate the N‐oxopiperidinium oxidant (III) as a functionality into the products are described.
ChemInform Abstract: Easily Accessible Auxiliary for Palladium‐Catalyzed Intramolecular Amination of C(sp2)—H and C(sp3)—H Bonds at δ‐ and ε‐Positions.
Authors: Wang Chao , Chen Changpeng , Zhang Jingyu , Han Jian , Wang Qian , Guo Kun , Liu Pei , Guan Mingyu , Yao Yingming , Zhao Yingsheng
Published: February 2015

An oxalamide derived N,O‐bidentate auxiliary is developed to offer the synthesis of various 5‐ and 6‐membered nitrogen heterocycles.
ChemInform Abstract: Cobalt‐Catalyzed, Aminoquinoline‐Directed Coupling of sp2 C—H Bonds with Alkenes.
Authors: Grigorjeva Liene , Daugulis Olafs
Published: February 2015

The coupling of N‐(8‐quinolinyl) substituted amides with olefins is developed using air as the oxidant.
ChemInform Abstract: An Efficient Synthesis of Pyrroline‐Fused Acridine Derivatives Catalyzed by Silica Sulfuric Acid.
Authors: Hu Ming‐Hua , Lin Wei , Cao Cheng‐Pao , Huang Zhi‐Bin , Shi Da‐Qing
Published: February 2015

The title compounds (III) and (V) are efficiently obtained by cascade reaction of isatins with enaminones.
ChemInform Abstract: A One‐Pot Four‐Component Synthesis of Pyrrolo[1,2‐a]quinolines
Authors: Adib Mehdi , Azimzadeh Marjan , Rahimi‐Nasrabadi Mehdi , Zhu Long‐Guan
Published: February 2015

under solvent‐free conditions
ChemInform Abstract: Synthesis of 2,5,7‐Triaryl‐4,7(6,7)‐dihydropyrazolo[1,5‐a]pyrimidine‐3‐carbonitriles by Reaction of 5(3)‐Amino‐3(5)‐aryl‐1H‐pyrazole‐4‐carbonitriles with Chalcones.
Authors: Kolosov Maksim A. , Beloborodov Dmitriy A. , Kulyk Olesia G. , Orlov Valeriy D.
Published: February 2015

In DMSO solution, derivatives (III) exist in equilibrium of two tautomeric forms in various ratios depending on the nature of aryl substituents in chalcone building blocks.
ChemInform Abstract: A Regioselective Biginelli‐Like Reaction Controlled by the Size of Alicyclic Mono‐ketones.
Authors: Wan Yu , Yuan Rui , Xu Hua‐hong , Wang Chao , Qi Jin‐long , Wu Hui
Published: February 2015

The regioselective Biginelli‐like reaction of alicyclic mono‐ketones, aromatic aldehydes, and urea in ionic liquid is controlled by the size of the alicyclic mono‐ketones and the steric hindrance of aromatic aldehydes.
ChemInform Abstract: 8‐Alkyl[1,2,4]triazolo[5,1‐b]purines.
Authors: Savateev K. V. , Ulomsky E. N. , Borisov S. S. , Voinkov E. K. , Fedotov V. V. , Rusinov V. L.
Published: February 2015

A novel, regioselective method for the synthesis of the title compounds (VI) as structural analogues of unnatural nucleosides is developed.
ChemInform Abstract: A Synthesis of Novel Pyrazolylthienopyrimidine Derivatives as IL‐6/STAT3 Inhibitors.
Authors: Kim Sung Min , Lee Seung Woong , Song Yang‐Heon
Published: February 2015

A series of title compounds of type (III) are prepared and screened as IL‐6/STAT3 inhibitors.
ChemInform Abstract: Access to 6‐Arylpyrrolo[2,3‐d]pyrimidines via a Palladium‐Catalyzed Direct C—H Arylation Reaction.
Authors: Dodonova Jelena , Tumkevicius Sigitas
Published: February 2015

The title compounds are prepared by regioselective 6‐arylation of 7‐methyl‐2,4‐diaryl‐7H‐pyrrolo[2,3‐d]pyrimidines (I), (IV), and (VI) with aryl bromides (II).
ChemInform Abstract: A Highly Efficient Procedure for the Synthesis of Quinoxaline Derivatives Using Polyvinylpolypyrrolidone Supported Triflic Acid Catalyst (PVPP·OTf).
Authors: Khaksar Samad , Tajbakhsh Mahmoud , Gholami Milad , Rostamnezhad Fariba
Published: February 2015

Supported TfOH appears to be a useful and recyclable heterogeneous catalyst for the rapid and efficient synthesis of guinoxaline derivatives via condensation of aromatic 1,2‐diamines with 1,2‐dicarbonyl compounds in water.
ChemInform Abstract: Regioselective Synthesis of Thiophene Fused Sultam Derivatives via Iodocyclization Approach and Their Application Towards Triazole Linker.
Authors: Barange Deepak Kumar , Kavala Veerababurao , Kuo Chun‐Wei , Wang Cheng‐Chuan , Rajawinslin R. R. , Donala Janreddy , Yao Ching‐Fa
Published: February 2015

An efficient synthesis of 4‐iodo‐thieno[3,2‐e]thiazines (II) via intramolecular iodocyclization is described.