bluuebunny/crossref_metadata_2025 huggingface dataset:
Efficacy of a Web App for Cognitive Training (MeMo) Regarding Cognitive and Behavioral Performance in People With Neurocognitive Disorders: Randomized Controlled Trial
Authors: Robert Philippe , Manera Valeria , Derreumaux Alexandre , Ferrandez Y Montesino Marion , Leone Elsa , Fabre Roxane , Bourgeois Jeremy
Published: February 2020

Background

Cognitive and behavioral symptoms are the clinical hallmarks of neurocognitive disorders. Cognitive training may be offered to reduce the risks of cognitive decline and dementia and to reduce behavioral symptoms, such as apathy. Information and communication technology approaches, including serious games, can be useful in improving the playful aspect of computerized cognitive training and providing motivating solutions in elderly patients.

Objective

The objective of this study was to assess the effectiveness of employing the MeMo (Memory Motivation) Web app with regard to cognitive and behavioral symptoms in patients with neurocognitive disorders.

Methods

MeMo is a Web app that can be used on any Web browser (computer or tablet). The training activities proposed in MeMo are divided into the following two parts: memory and mental flexibility/attention. The study included 46 individuals (mean age 79.4 years) with a diagnosis of neurocognitive disorders at the Institut Claude Pompidou Memory Center in Nice. This randomized controlled study compared the evolution of cognition and behavior between patients not using MeMo (control group) and patients using MeMo (MeMo group) for 12 weeks (four sessions per week). Patients underwent memory and attention tests, as well as an apathy assessment at baseline, week 12 (end of the training period), and week 24 (12 weeks after the end of the training sessions). In addition, to assess the impact of high and low game uses, the MeMo group was divided into patients who used MeMo according to the instructions (about once every 2 days; active MeMo group) and those who used it less (nonactive MeMo group).

Results

When comparing cognitive and behavioral scores among baseline, week 12, and week 24, mixed model analysis for each cognitive and behavioral score indicated no significant interaction between testing time and group. On comparing the active MeMo group (n=9) and nonactive MeMo group (n=13), there were significant differences in two attention tests (Trial Making Test A [P=.045] and correct Digit Symbol Substitution Test items [P=.045]) and in the Apathy Inventory (AI) (P=.02). Mixed analysis (time: baseline, week 12, and week 24 × number of active days) indicated only one significant interaction for the AI score (P=.01), with a significant increase in apathy in the nonactive MeMo group.

Conclusions

This study indicates that the cognitive and behavioral efficacies of MeMo, a Web-based training app, can be observed only with regular use of the app. Improvements were observed in attention and motivation.

Trial Registration

ClinicalTrials.gov NCT04142801; https://clinicaltrials.gov/ct2/show/NCT04142801
Development and Testing of a Personalized Web-Based Diet and Physical Activity Intervention Based on Motivational Interviewing and the Self-Determination Theory: Protocol for the MyLifestyleCoach Randomized Controlled Trial (Preprint)
Authors: Coumans Juul M J , Bolman Catherine A W , Friederichs Stijn A H , Oenema Anke , Lechner Lilian
Published: February 2020

BACKGROUND

Unhealthy dietary patterns and insufficient physical activity (PA) are associated with negative health outcomes, such as cardiovascular diseases, type 2 diabetes, cancer, overweight, and obesity. This makes the promotion of healthy dietary and PA behaviors a public health priority.

OBJECTIVE

This paper describes the development, design, and evaluation protocol of a Web-based computer-tailored (CT) dietary and PA promotion intervention, MyLifestyleCoach. A Web-based format was chosen for its accessibility and large-scale reach and low-cost potential. To achieve effective and persistent behavioral change, this innovative intervention is tailored to individual characteristics and is based on the self-determination theory and motivational interviewing (MI).

METHODS

The 6 steps of the intervention mapping protocol were used to systematically develop MyLifestyleCoach based on the existing effective CT PA promotion intervention I Move. The MyLifestyleCoach intervention consists of 2 modules: I Move, which is aimed at promoting PA, and I Eat, which is aimed at promoting healthy eating. Development of the I Eat module was informed by the previously developed I Move. Both modules were integrated to form the comprehensive MyLifestyleCoach program. Furthermore, I Move was slightly adapted, for example, the new Dutch PA guidelines were implemented. A randomized controlled trial consisting of an intervention condition and waiting list control group will be used to evaluate the effectiveness of the intervention on diet and PA.

RESULTS

Self-reported measures take place at baseline, 6 months, and 12 months after baseline. Enrollment started in October 2018 and will be completed in June 2020. Data analysis is currently under way, and the first results are expected to be submitted for publication in 2020.

CONCLUSIONS

MyLifestyleCoach is one of the first interventions to translate and apply self-determination theory and techniques from MI in Web-based computer tailoring for an intervention targeting PA and dietary behavior. Intervention mapping served as a blueprint for the development of this intervention. We will evaluate whether this approach is also successful in promoting eating healthier and increasing PA using an randomized controlled trial by comparing the intervention to a waiting list control condition. The results will provide an insight into the short- and long-term efficacy and will result in recommendations for the implementation and promotion of healthy eating and PA among adults in the Netherlands.

CLINICALTRIAL

Dutch Trial Register NL7333; https://www.trialregister.nl/trial/7333

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/14491
Use and perceptions of digital health wearables by college students: A survey research study (Preprint)
Authors: Alva Dianna , Martinez Lourdes , Crespo Noe , Walsh-Buhi Eric R.
Published: February 2020

BACKGROUND

For many emerging adults, the transition to college can mark a critical life stage with increased risk for weight gain and obesity, the results of which may bring early onset of chronic disease and mortality. Weight gain among college students is a well-documented phenomenon, with current estimates placing the prevalence of obesity among college students in the United States at around 30%. Digital wearable devices may offer a promising solution toward further addressing the issue of weight gain and obesity. Wearables are defined as devices, accessories or clothing items utilizing computer and electronic technology to track, monitor and/or detect symptoms, behaviors or other health outcomes, and include pedometers, Fitbits or other activity/sleep monitoring bands or devices and smart phone apps used for health tracking and goal-setting.

OBJECTIVE

This paper reports on college students’ engagement with health tracking wearable devices including their specific device uses, intentions of use, satisfaction, and perception of benefits. We further explored characteristics of students who initiate and sustain use of their devices for longer than six months.

METHODS

Participants included undergraduate students at a large, urban public university in the Southwestern USA in 2017. A cross-sectional survey was administered and assessed college students’ use and perceptions of health tracking wearables. Method: Descriptive statistics summarize the data on participants’ common responses to device use and perceptions. Bivariate correlations were employed to identify characteristics of respondents who initiate and sustain engagement.

RESULTS

86% of respondents currently or previously owned a digital health wearable device. Less than 1% reported that they have never owned a device and would not be interested in ever owning one. Cell phone apps were the most commonly used device, followed by fitness tracking bands. Devices were most frequently used to track steps or exercise routine (81%), diet, calories, or weight (54%), and sleep (26%). About half of wearable users (48%) reported that they share data they collect, socially, from their wearables. It was found that high perceived usefulness and satisfaction, exercise levels, and high perception of social norms were statistically significantly correlated with sustained use.

CONCLUSIONS

In using wearables among college students to promote long-term healthy behavior changes, there are opportunities to utilize the critical roles that perceived social norms and perceived usefulness of a device can have on one’s long-term behaviors while emphasizing any enjoyable user experiences created by these devices.
Ethical considerations for monetizable big data in healthcare (Preprint)
Authors: Cahan Eli M. , Hernandez-Boussard Tina , Thadaney-Israni Sonoo
Published: February 2020

UNSTRUCTURED

Since Henrietta Lacks’ death from cervical cancer, so-called HeLa cells have become a ubiquitous substrate for scientific advancement. Such scientific advancement has bred innovation, and innovation, profit. Yet, these innovations have been unevenly distributed across demographic groups. To ensure the ethical conduct of research and the equitable distribution of its benefits, biospecimens, like HeLa’s tissue, were protected under consent conventions of the Belmont Report. Likewise, during the genomic era, the “biospecimen" concept was forced to evolve again. A third era—that of informatics—has the potential to empower truly “personalized” medicine. Nonetheless, issues related to unequal focus of research efforts and unequal provision of innovation already exist. Additionally, with increasing ease of re-identification, the anonymity of individualized data is at risk. Redesign of consent protocols and redefinition of the biospecimen concept may be required once more to protect the donors of de-identified transcriptomic data—and their families, in the long-run.
Heart Rate Measurements in Patients with Obstructive Sleep Apnea and Atrial Fibrillation: Prospective Pilot Study Assessing Apple Watch’s Agreement With Telemetry Data (Preprint)
Authors: Huynh Pauline , Shan Rongzi , Osuji Ngozi , Ding Jie , Isakadze Nino , Marvel Francoise A , Sharma Garima , Martin Seth S
Published: February 2020

BACKGROUND

Patients with obstructive sleep apnea (OSA) are at a higher risk for atrial fibrillation (AF). Consumer wearable heart rate (HR) sensors may be a means for passive HR monitoring in patients with AF.

OBJECTIVE

The aim of this study was to assess the Apple Watch’s agreement with telemetry in measuring HR in patients with OSA in AF.

METHODS

Patients with OSA in AF were prospectively recruited prior to cardioversion/ablation procedures. HR was sampled every 10 seconds for 60 seconds using telemetry and an Apple Watch concomitantly. Agreement of Apple Watch with telemetry, which is the current gold-standard device for measuring HR, was assessed using mixed effects limits agreement and Lin’s concordance correlation coefficient.

RESULTS

A total of 20 patients (mean 66 [SD 6.5] years, 85% [n=17] male) participated in this study, yielding 134 HR observations per device. Modified Bland–Altman plot revealed that the variability of the paired difference of the Apple Watch compared with telemetry increased as the magnitude of HR measurements increased. The Apple Watch produced regression-based 95% limits of agreement of 27.8 – 0.3 × average HR – 15.0 to 27.8 – 0.3 × average HR + 15.0 beats per minute (bpm) with a mean bias of 27.8 – 0.33 × average HR bpm. Lin’s concordance correlation coefficient was 0.88 (95% CI 0.85-0.91), suggesting acceptable agreement between the Apple Watch and telemetry.

CONCLUSIONS

In patients with OSA in AF, the Apple Watch provided acceptable agreement with HR measurements by telemetry. Further studies with larger sample populations and wider range of HR are needed to confirm these findings.
FORMULATION AND EVALUATION OF ANTIMICROBIAL OINTMENTS FROM EUPATORIUM GLANDULOSUM HORT. EX KUNTH
Authors: SILPA M  , SURESH JOGHEE  , HAMSALAKSHMI
Published: February 2020

Objective: The present study was undertaken to evaluate the antimicrobial activity of an ointment prepared from alcohol, ethyl acetate, and chloroform extracts of Eupatorium glandulosum Hort. ex Kunth.

Methods: The dried plant materials of E. glandulosum were individually extracted using alcohol, ethyl acetate, and chloroform by Soxhlet method. These three different types of extracts were used for the preparation of ointment and evaluated for the phytochemicals, pH, homogeneity, spreadability, tube extrudability, stability, and antimicrobial activity. The activity of prepared ointments was evaluated against Escherichia coli and Bacillus subtilis and the in vitro antimicrobial activity of ointments of plant extracts was performed by cup plate methods. The most effective antimicrobial ointment was determined by comparing the results of the zone of inhibition of all the ointments of each solvent extract.

Results: The antimicrobial activity of optimized formulation was showed significant activity against the tested bacterial pathogens.

Conclusion: The present study confirmed the antimicrobial activity of the formulations. Furthermore, it can use as a potential dosage form for clinical utility. The results are the justification for the use of the plant in folk medicine.
STUDY OF DIRECT COMPRESSION METHOD FOR THE PREPARATION OF QUINAPRIL HYDROCHLORIDE TABLETS
Authors: SHWETHA MARGRET JL  , MADHAVI BLR
Published: February 2020

Objective: Direct compression method is preferable for tablet manufacture. The direct compression method is followed for many formulations but the relevant study is not reported. The present work aims to study the suitability of the direct compression process to prepare tablets of quinapril hydrochloride (QHCl), a low dose drug with a starting dose of 5 mg, indicated in the treatment of hypertension, congestive heart failure, and other conditions.

Methods: QHCl is reported to be unstable in the presence of moisture, heat, and some excipients. The direct compression method was tried instead of a wet granulation technique to prepare the tablets. Initially, drug-excipient compatibility study was carried out. For selected excipients and QHCl preformulation tests were conducted. The stabilizer was employed. Three formulations were tried. The blends were prepared by tumbling and trituration methods. Blend uniformity and precompression parameters were determined. Tablets were directly compressed and evaluated.

Results: Drug-excipient compatibility was studied at 60°C and 40°C with an Relative humidity (RH) of 75% for 4 weeks. It showed discoloration of the pure drug and most of the drug excipient mixtures. Three formulations Q1, Q2, and Q3 were prepared using magnesium oxide (light), magnesium carbonate (light), and Aerosil as stabilizers. Blending was done by trituration and tumbling method for 10 min and 15 min duration for the given batch size. Blend uniformity was determined. Tumbling method for 15 min showed good blending as evident from the percentage coefficient of variation values. The blends had a good flow. Tablet evaluation showed hardness in the range of 2.5–3 kg/cm2 and disintegration time of 1–2 min. Q1 and Q2 passed the friability test. The content uniformity criterion was achieved with an acceptance value <20. In vitro dissolution, Q1 and Q2 were 100% and 98.8%, respectively, in 30 min and followed first-order kinetics. The stability study of Q1 indicated a single peak in the chromatogram corresponding to the drug. Q2 showed spotted discoloration.

Conclusion: The direct compression technique could be employed for the preparation of QHCl tablets. Q1 showed better stability and release characteristics. Q2 and Q3 are considered for further study.
EFFECT OF SLEEP DEPRIVATION ON REMINISCENCE AND APPREHENSION BEHAVIOR IN WISTAR ALBINO RATS
Authors: PRIYA CS KEERTHI , S MALATHI , RAJAN RAVINDRAN
Published: February 2020

Objective: The aim of the present study is to investigate the effect of paradoxical sleep deprivation (SD) on learning and memory impairment and anxiety-like behavior in female Wistar albino rats.

Methods: Eight-arm radial maze, open-field test, and light and dark test were used to assess the animals learning and memory and anxiety-like behavior.

Results: SD associated with weaker learning and memory and increased anxiety- and depressive-like behavior in animals.

Conclusion: Animals were exposed to SD showed learning and memory impairment and also exhibited increased anxiety- and depressive-like behavior when compared to control animals.
AMELIORATION OF ACETAMINOPHEN-INDUCED HEPATOTOXICITY USING SOLANUM TORVUM SW. FRUIT EXTRACT IN WISTAR RATS
Authors: UMERA BEGAM AK  , SENTHILKUMAR R  , SIRAJUDEEN J
Published: February 2020

Objective: Ayurveda and Chinese pharmacopeia have highlighted the traditional medicinal uses of Solanum torvum Sw. The fruits are ethnomedical used in the treatment of liver and spleen enlargement, cough, and also used as a hematopoietic, antimicrobial, and analgesic agent. In the present study, the amelioration of acetaminophen (APAP)-induced hepatotoxicity of the aqueous extract of S. torvum Sw. fruits is evaluated.

Methods: The hepatoprotective activity of the fruit extract against APAP insult was evaluated by assessing it is in vivo antioxidants status, membrane-bound adenosine triphosphatases (ATPases), and tricarboxylic acid (TCA) cycle marker enzymes and also through histopathological studies of the liver.

Results: Administration of the aqueous fruit extract of the plant caused a significant increase in the in vivo antioxidant status as evident from the reduction in lipid peroxidation caused by APAP and improvement in the mitochondrial membrane stability which is proved from the activity of membrane-bound ATPases and TCA cycle marker enzymes. Histological studies also supported the fact that the plant extract proved to revive the architecture of the toxin damaged liver tissues in par with silymarin. The chemical pathological changes were consistent with histopathological observations suggesting marked hepatoprotective effect of the aqueous extract of S. torvum.

Conclusion: The results showed that the extract of S. torvum Sw. fruits has hepatoprotective potential which may be due to the antioxidant activity of its phytoconstituents, especially flavonoids, alkaloids, phenolics, etc.
ELECTRICAL VESTIBULAR NERVE STIMULATION FOR THE MANAGEMENT OF TENSION HEADACHE
Authors: SAI SAILESH KUMAR GOOTHY  , SRILATHA GOOTHY  , JASON MCKEOWN
Published: February 2020

Tension headache is the most common type of headache and typically it is described as pain or pressure in the head, scalp, or neck, often associated with localized muscle discomfort. It was hypothesized that stimulation of vestibular nerve may relieve pain. In this single-person study, vestibular nerve stimulation was administered daily for a period of 6 weeks. The participant was an 18 years male with a 4 years history of moderate headache at least once week and with repeated periods of moderate stress. He was under medications; however, the pain was not relieved. Stress levels were measured using DASS 21 scale. Pain was measured using pain scale, autonomic, and cognitive parameters recorded by standard methods. During this study, the participant reported a significant reduction in both the frequency and intensity of headaches and by the end of the 6 weeks of the study, it was noticed that he reduced the usage of pain medication. Autonomic parameters remained within normal limits after the periods of stimulation and cognitive functions were improved. This study suggests that electrical stimulation of the vestibular nerve may help to reduce tension headache and highlights the need for larger studies in this area and further exploratory studies in the management of other regional pain such as orofacial pain, dental pain, and management of pain after mandibular surgery.
SIMPLE BIOANALYTICAL QUANTIFICATION METHOD FOR SIMULTANEOUS ESTIMATION OF SIMVASTATIN AND EZETIMIBE IN HUMAN PLASMA BY REVERSE-PHASE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY TECHNIQUE
Authors: DYADE GK  , SAWANT RL
Published: February 2020

Objective: A bioanalytical quantification method was developed for the simultaneous estimation of simvastatin (SIM) and ezetimibe (EZE) from the human plasma.

Methods: The technique was developed and equipped with reverse-phase (RP) high-performance liquid chromatography, using RP-C18 column with an ultraviolet detector. For the estimation of SIM and EZE, the mobile phase (acetonitrile:acetate buffer pH 4.0, pH adjusted with acetic acid) was pumped at a flow rate of 0.8 ml/min in the ratio of 85:15% v/v and the eluents were monitored at 234 nm. A calibration graph to study linearity of the SIM and EZE in biological matrix was carried out in the concentration range of 400–4000 ng/ml for both these drugs SIM and EZE.

Results: The developed method was validated according to the US FDA and European Medicines Agency guidelines for sensitivity, accuracy, precision, and stability. The obtained statistical data of validation were found to be within prescribed limit assures rigidity of the method. Both the drugs in combined form were estimated in human plasma by the proposed method.

Conclusions: The developed method is free from solid-phase extraction so it becomes simple and economical. The method is efficient for precise and accurate quantification of SIM and EZE in plasma and hence applied for bioequivalence, bioavailability study in real clinical samples.
THE INFLUENCE OF PARTICIPATIVE COUNSELING APPROACH ON IMPROVING BREASTFEEDING SELF-EFFICACY TO PREGNANT WOMEN IN INDONESIA
Authors: FAUZIA FAUZIA  , NI WAYAN DIAN EKAYANTHI  , AHMAD FUDHOLI
Published: February 2020

Objective: The objective of this study was to know the effect of participatory counseling on increasing breastfeeding self-efficacy (BSE) in pregnant women in Bogor city, Indonesia.

Methods: The pre-experimental design method, namely, one group pretest-posttest, with the number of study subjects was 35 third trimester pregnant women with normal reproductive age without complications in the Bogor City. Data analysis was performed by univariable and bivariable by Friedman test and Wilcoxon post hoc test and multivariable using linear regression test.

Results: Participatory counseling has an effect on increasing breastfeeding efficacy in pregnant women (p<0.001), while confounding variables (education, parity, own breastfeeding experience, and other’s experience of breastfeeding) have no significant effect on increasing BSE in pregnant women (p>0.05).

Conclusion: Participatory counseling increases BSE in pregnant women.
IVABRADINE HYDROCHLORIDE DIRECTLY COMPRESSED TABLETS USING NANO-CELLULOSE EXTRACTED FROM ARACHIS HYPOGAEA SHELLS
Authors: JEEVANA JYOTHI B  , APARNA J
Published: February 2020

Objective: The main objective of this work was the extraction of nanocellulose from Arachis hypogaea shells, characterization of nanocellulose, development, and in vitro evaluation of directly compressed tablets of ivabradine hydrochloride (IVH) using nanocellulose.

Methods: IVH and colloidal silicon dioxide are gift samples from Mylan Laboratory, Hyderabad, and Karnataka Antibiotics and Pharmaceuticals Ltd., Bengaluru, respectively. Nanocellulose was extracted from A. hypogaea shells by alkaline treatment followed by acid hydrolysis and it was characterized by particle size analysis by zeta sizer, melting point determination, differential scanning calorimetry (DSC), and Fourier transform infrared (FTIR) analysis. Compatibility between IVH and nanocellulose was confirmed by FTIR and DSC analysis. Then, fast-release tablets of containing 5 mg of IVH were prepared by direct compression using various compositions containing nanocellulose, starch, and colloidal silicon dioxide and evaluated.

Results: Nanocellulose in the size of 273.4 nm was extracted from A. hypogaea shells to possess its ideal characteristics. IVH and nanocellulose were compatible according to FTIR and DSC analysis. Fast-release tablets of IVH were prepared as directly compressed tablets by direct compression. Tablets made with 5 mg of IVH and nanocellulose, starch, and colloidal silicon dioxide evidenced fast release of 96.37% in 5 min.

Conclusion: Nanocellulose from A. hypogaea shells can be produced successfully by alkali treatment followed by acid hydrolysis, ball milling, and lyophilization. This nanocellulose can be exploited successfully for the design of fast-release tablets of IVH.
EVALUATION OF INNOVATED FORMULA OF BISACODYL SUPPOSITORY FOLLOWING THE DISSOLUTION PROFILE AND STABILITY DATA USING DEVELOPED HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY METHOD
Authors: J HASSON KAHTAN , G JABAR ESRAA , I ALKHALIFA IHAB
Published: February 2020

Objective: Bisacodyl is a laxative drug used in the treatment of constipation, it is soluble in mineral acids, but it is practically insoluble in water. Therefore, it is very hard task to dissolve bisacodyl in alkaline medium so the objective of this study was the development of proper dissolution method for a new formulation of bisacodyl suppositories in a medium simulated to rectal region. Obviously, most of the bisacodyl suppositories preparation products will yield low percentages of dissolution in the alkaline medium of phosphate buffer pH 7.2.

Methods: Preparation inclusion complex of bisacodyl with the solubilizing agent beta-cyclodextrin then incorporated in a suppository base. The quantitative analysis of bisacodyl in suppositories was carried by a developed and validated high-performance liquid chromatography method.

Results and Discussion: The dissolution rates for the innovated formulation of bisacodyl complexed with beta-cyclodextrin suppositories were in average of 97.5% and the stored suppositories of this formulation maintained their specified physical and chemical properties along the real stability study.

Conclusion: The application of the inclusion complexation technique of bisacodyl with beta-cyclodextrin in the production of suppositories enhances the dissolution rate and improves the stability of suppositories performance.
Assessment of antimicrobial activity in Diplostephium phylicoides and Diplostephium revolutum extracts by plates and wells method
Authors: Palacios Janeth Arias
Published: February 2020

Abstract. In the present work, the evaluation of the antimicrobial activity of Diplostephium phylicoides and Diplostephium revolutum on different microorganisms was carried out on using bacteria such as Escherichia coli (CMPUJ:034), Staphylococcus aureus (CMPUJ:370), Salmonella typhi (CMPUJ:045) and Pseudomonas aeruginosa (CMPUJ:065), yeasts such as Saccharomyces cerevisiae (CMPUJ:H042) and Candida albicans (CMPUJ:H022), and filamentous fungi such as Penicillium chrysogenum (CMPUJ:H061) and Aspergillus niger (CMPUJ:H002). This assessment was made by the method of plates and wells using extracts from the leaves of the previously mentioned plants. The extracts were made with different solvents, ethanol, ethyl acetate, dichloromethane and petroleum ether. The results showed that the ethyl acetate extract of Diplostephium phylicoides has antimicrobial activity against Staphylococcus aureus and Candida albicans; furthermore, the dichloromethane extract showed an inhibitory effect against Saccharomyces cerevisiae. When comparing the extracts of the two plants, under the evaluated conditions, the extracts presented antimicrobial activity, and the ethyl acetate extract of Diplostephium revolutum the one that showed better activity against all the microorganisms.
En torno a un nuevo realismo feminista como superación ontológica del constructivismo sociolingüisticista
Authors: Binetti María J
Published: February 2020

La segunda mitad del siglo xx ha estado dominada por el giro lingüístico y la conversión de la filosofía en un sociologismo de/constructivista. En el ámbito de las teorías feministas, el paradigma sociolingüisticista avanzó desde la incorporación del “género” como categoría hegemónica hacia la disolución transgenérica de lo sexual y su remate en la queerización del feminismo y la eliminación de las mujeres como sujetos ontológicos. Por el contrario, el siglo xxi ha levantado su vuelo especulativo sobre el agotamiento de la posmodernidad discursiva, con la certeza ontológica de lo real en su consistencia irreductible a discursos, textos, interpretaciones, relaciones económicas o normativas biotecnológicas. En el marco del así llamado nuevo giro especulativo o realista, las siguientes páginas intentarán reontologizar la diferencia sexual femenina por fuera de la falsa alternativa dualista esencialismo vs. antiesencialismo o sustancialismo vs. nominalismo a la cual ha sido posmetafísicamente forzada.
Escuchar la ley
Authors: Parrini Roses Rodrigo
Published: February 2020

Reseña de El género en la ley penal: crítica feminista a la ilusión punitiva
Repensar categorías fundamentales en la escritura de la historia de las mujeres
Authors: Núñez B. Fernanda
Published: February 2020

Repensar categorías fundamentales en la escritura de la historia de las mujeres
redes de la sexualidad en Tehuantepec
Authors: Constant Chloé
Published: February 2020

Reseña del libro Las redes de la sexualidad en Tehuantepec. Belleza, espacio, prácticas sexuales, maternidad y violencia íntima
artistas españolas y su actividad económica: trabajo precario en tiempos de crisis. Análisis y comparativa a partir de un estudio global
Authors: Pérez Ibáñez Marta , López-Aparicio Pérez Isidro
Published: February 2020

Este artículo describe la actividad profesional y económica de las artistas españolas, a partir de los resultados obtenidos en el estudio realizado por los autores a nivel nacional con datos provistos por más de 1,100 artistas. Es el primer análisis en profundidad sobre el sector de artistas plásticas/os y visuales en España, su actividad profesional y circunstancias económicas y laborales, su relación con agentes del mercado del arte y la evolución histórica de las últimas décadas. Se ha segmentado el colectivo de mujeres artistas, 52% del total, y se han contextualizado y analizado sus circunstancias en comparación con las de los hombres y con los datos globales, dentro de la actual coyuntura económica española. Además de ofrecer aspectos generales de la actividad artística de las mujeres en España y su relación con el mercado, se aportan datos que reafirman nuestra hipótesis sobre el grado de precariedad y desigualdad que sufren las artistas españolas, agravada por su menor visibilidad en el sistema del arte.
Abanico de maternidades. Un estado del arte desde los aportes feministas
Authors: Romero Guzmán María Lizet , Tapia Tovar Evangelina , Meza Márquez Consuelo
Published: February 2020

El artículo contiene un estado del arte de investigaciones prominentes que han abordado las maternidades desde los estudios feministas de la segunda ola y desde los Estudios de género, cuyas autoras, principalmente del hemisferio occidental, tomaron referentes de la historia, la sociología y la antropología. Abre con un enfoque histórico con el fin de contextualizar la maternidad como una construcción cultural multiforme; posteriormente, presenta investigaciones de maternidades diversas, señaladas por salirse de los parámetros de la maternidad tradicional: madres adolescentes, madres lesbianas, madres filicidas, mujeres que no quieren ser madres, madres feministas. El análisis de las contribuciones posibilita vertientes de debates actuales a nivel nacional e internacional. Asimismo, puntea directrices para la continuación y la profundización en estudios sobre las llamadas “nuevas maternidades”. Abanico
Predicción de opinión going concern en clubes de fútbol: evidencia para la liga española
Authors: Alaminos David , Del Castillo Agustín , Fernández Manuel Ángel
Published: February 2020

El principio contable de gestión continuada (going concern) ha sido foco de atención de la investigación financiera en las últimas décadas, y ha dado lugar al desarrollo de modelos de predicción de opiniones de auditoría calificadas por going concern que ayudan a evaluar la continuidad de las empresas. Dichos modelos se han centrado exclusivamente en empresas industriales y financieras. Sin embargo, no se ha creado un modelo específico que recoja las especiales características de la industria del fútbol. Dado que recientemente los órganos de gobierno de la industria del fútbol han aumentado el control financiero de los clubes, como es el caso de la UEFA con la aprobación del Reglamento de Fair Play Financiero, y exigen un pronunciamiento sobre going concern en las cuentas anuales de los clubes, parece necesario disponer de un modelo adaptado a las características propias de esta industria. El presente trabajo proporciona un modelo exclusivo de predicción de opiniones de auditoría calificadas por going concern en la industria del fútbol con una precisión que supera el 95%. También ofrece una visión de los desafíos a los que se enfrenta la industria del fútbol en materia financiera, ayudando a los distintos grupos de interés a evaluar las expectativas de continuidad de los clubes.
A Cluster-First Route-Second Heuristic Approach to Solve The Multi-Trip Periodic Vehicle Routing Problem
Authors: Garside Annisa Kesy , Laili Nabila Rohmatul
Published: February 2020

This paper discusses periodic vehicle routing problems that allow vehicles to travel on multiple trips in a single day. It is known as the Multi-Trip Periodic Vehicles (MTPVRP) Problem Route. Cluster-first route-second (CFRS) heuristics to solve MTPVRP was proposed in this study. In phase 1, customers were divided into clusters using the formulation of integer programming. Phase 2 determined the route of the cluster and verified that the total journey time to visit the trips does not exceed the working hours of the vehicle. Implementing the heuristic CFRS to solve the real problem faced by the  Liquefied petroleum gas (LPG) distributor shows that the procedure could provide a better routing solution.
REMOÇÃO CIRÚRGICA DE CISTO RADICULAR COM TRATAMENTO ENDODÔNTICO RETRÓGRADO: 2 ANOS DE ACOMPANHAMENTO
Authors: Almeida Costa Yasmin Jeane
Published: February 2020

RESUMO             O cisto inflamatório radicular é uma cavidade patológica verdadeiramente revestida por epitélio geralmente originária de um dente desvitalizado com necrose pulpar. Sua exérese, quando devidamente indicada, é necessária devido a possibilidade de alcançar grandes proporções provocando a destruição do tecido ósseo circundante, além de ser foco para o desenvolvimento de processos infecciosos. A técnica de enucleação cística com tratamento endodôntico retrógrado, permite que a lesão seja removida preservando-se os elementos dentários envolvidos. Este trabalho tem como objetivo relatar e discutir o caso clínico realizado nas clínicas de Cirurgia Oral Menor e Endodontia da Faculdade de Odontologia da Universidade Federal Fluminense (UFF). O exame histopatológico, realizado no Laboratório Associado de Pesquisa Clínica em Odontologia da UFF comprovou a suspeita diagnóstica inicial de cisto radicular. Concluímos que o tratamento do cisto radicular inflamatório é bastante previsível quando precedido de uma minuciosa abordagem clínica pré-operatória. A conduta terapêutica adotada para este caso foi correta e conduziu o paciente à cura, recebendo alta definitiva após dois anos de acompanhamento.Palavras-chave: Cirurgia Paraendodôntica. Cisto Radicular. Apicectomia. Cistos Odontogênicos. Enucleação Cística. Obturação Simultânea. ABSTRACT  The radicular inflammatory cyst is a pathological cavity truly lined with epithelium, usually originating from a devitalized tooth with pulp necrosis. Its excision, when properly indicated, is necessary due to the possibility of reaching large proportions destroying the surrounding bone tissue, besides being a focus for the development of infectious processes. The cystic enucleation technique with retrograde endodontic treatment allows the lesion to be removed while preserving the involved dental elements. This paper aims to report and to discuss the case report conducted at the Clinics of Minor Oral Surgery and Endodontics, Faculty of Dentistry, Fluminense Federal University (UFF). The histopathological examination, performed at the Associated Laboratory of Clinical Research in Dentistry of UFF, confirmed the initial diagnostic suspicion of root cyst. We conclude that the treatment of the inflammatory root cyst is quite predictable when preceded by a thorough preoperative clinical approach. The therapeutic approach adopted for this case was correct and led the patient to cure and was discharged after two years of follow-up.Keywords: Paraendodontic Surgery. Radicular Cyst. Apicoectomy. Odontogenic Cyst. Cystic Enucleation. Simultaneous Filling.
Pengetahuan dan Sikap Masyarakat dalam Pencegahan dan Pemberantasan Jentik Nyamuk Demam Berdarah Dengue (DBD) Di Jayaraga Garut
Authors: Sumarni Nina , Rosidin Udin , Witdiawati Witdiawati
Published: February 2020

Abstract. Cases of dengue hemorrhagic fever (DHF) are still a threat in Indonesia, especially entering the rainy season, the number of sufferers usually tends to increase, this occurs due to the proliferation of Aedes aegypti mosquito breeding breed. Prevention and eradication of dengue fever must be the responsibility of all communities. Efforts that can be done by the community are to be able to play an active role in monitoring mosquito larvae. This study aims to identify the knowledge and attitudes of the community in the prevention and eradication of dengue mosquito larvae. The head of the family in Jayaraga Garut, 103 kk, the amount of total populations, the study time was October 2018. Aspect Research Results Respondents' knowledge of participation in prevention and eradication of dengue vector still had 8 respondents whose knowledge was lacking. Attitude, there are still 9 responses whose attitude is not good. Participation in doing 3M most of the people of Jayaraga have prevented the breeding of the Aedes aegypti mosquito larvae even though there are still respondents who did nothing. The conclusion is that there are still some respondents whose knowledge, attitudes and actions are not good or not good.
Primary Care Behavioral Health Training in Family Medicine Residencies:
Authors: Landoll Ryan R. , Cervero Ronald M. , Quinlan Jeffrey D. , Maggio Lauren A.
Published: February 2020

Background and Objectives: Primary care behavioral health (PCBH) is a service delivery model of integrated care linked to a wide variety of positive patient and system outcomes. However, considerable challenges with provider training and attrition exist. While training for nonphysician behavioral scientists is well established, little is known about how to train physicians to work efficiently within integrated teams.
Methods: We conducted a case study analysis of family medicine residencies in the military health system using a series of 30 to 45-minute semistructured interviews. We conducted qualitative template analysis of these cases to chart programs’ current educational processes related to PCBH. Thirteen individuals consisting of program directors, behavioral and nonbehavioral faculty, and residents across five programs participated in the study.
Results: Current educational processes included a variety of content on PCBH (eg, treatment for depression, clinical referral pathways, patient-centered communication), primarily using a mix of didactic and practice-based placements. Resource allocation was seen as a critical contributor to quality. There was variability in the degree to which integrated behavioral health providers were incorporated as residency faculty, such that programs where these specialists were more incorporated reported more intentional curriculum development and health care systems-level content.
Conclusions: While behavioral health content was well represented in family medicine residency curriculum, the depth and integration of content was inconsistent. More intentional and integrated curriculum accompanied faculty development and integration of behavioral health faculty. Future research should evaluate if faculty development programs and faculty status of behavioral scientists results in different educational or health care outcomes.
Educating Physicians in Family Medicine Residencies About Nonpharmacologic Approaches to Pain:
Authors: Chiasson Ann Marie , Brooks Audrey J. , Ricker Mari , Lebensohn Patricia , Chen Mei-Kuang , Maizes Victoria
Published: February 2020

Background and Objectives: Opioid misuse is at an all-time crisis level, and nationally enhanced resident and clinician education on chronic pain management is in demand. To date, broad-reaching, scalable, integrative pain management educational interventions have not been evaluated for effectiveness on learner knowledge or attitudes toward chronic pain management.
Methods: An 11-hour integrative pain management (IPM) online course was evaluated for effect on resident and faculty attitudes toward and knowledge about chronic pain. Participants were recruited from family medicine residencies participating in the integrative medicine in residency program. Twenty-two residencies participated, with 11 receiving the course and 11 serving as a control group. Evaluation included pre/post medical knowledge and validated measures of attitude toward pain patients, self-efficacy for nondrug therapies, burnout, and compassion.
Results: Forty-three participants (34.4%) completed the course. The intervention group (n=50), who received the course, improved significantly (P<.05) in medical knowledge, attitude toward pain patients, and self-efficacy to prescribe nondrug therapies while the control group (n=54) showed no improvement. There was no effect on burnout or compassion for either group. The course was positively evaluated, with 83%-94% rating the course content and delivery very high. All participants responded that they would incorporate course information into practice, and almost all thought what they learned in the course would improve patient care (98%).
Conclusions: Our findings demonstrate the feasibility of an online IPM course as an effective and scalable intervention for residents and primary care providers in response to the current opioid crisis and need for better management of chronic pain. Future directions include testing scalability in formats that lead to improved completion rates, implementation in nonacademic settings, and evaluation of clinical outcomes such as decreased opioid prescribing.
Governança Colaborativa em Instituições de Ensino: Uma Quasi- Revisão Sistemática da Literatura
Authors: Ferreira Neves Danilo , Cerqueira Santos Lidiany , Alves Santos Mylena , Colaço Rodrigues Júnior Methanias
Published: February 2020

Contexto. Tecnologias para estimular a participação eletrônica vem sendo adotadas por governos como forma de legitimar direitos, promover transparência e resolver problemas de forma mais eficiente. Embora validada no cenário político, a governança colaborativa ainda é pouco adotada em centros acadêmicos. Objetivo. Entender e mapear como práticas colaborativas estão sendo adotadas na governança de instituições de ensino. Metodologia. Foi elaborada uma Quasi-revisão sistemática da literatura. Resultado. A busca selecionou 3 estudos entre 526. Após análise, foram identificados nos estudos os recursos pertinentes para viabilização de colaboração, as práticas de participação utilizadas e como a inserção desse modelo administrativo influenciou na qualidade de ensino e no desenvolvimento da comunidade acadêmica. Conclusão. Pelo caráter metodológico aplicado, o trabalho serve como um guia, identificando tendências e sintetizando práticas que podem ser replicadas em novos projetos.
Identificação dos fatores de melhorias no IDEB pelo uso de mineração de dados: Um estudo de caso em escolas municipais de Teotônio Vilela-Alagoas
Authors: Da Silva Pinto Glevson , De Gusmão Freitas Júnior Olival , De Barros Costa Evandro
Published: February 2020

A Mineração de Dados Educacionais vem auxiliando educadores e gestores no apoio a tomada de decisões, permitindo extração de informações relevantes de bases de dados. O objetivo deste artigo é identificar os fatores que afetam o desempenho escolar dos alunos (IDEB) das escolas de ensino fundamental do município de Teotônio Vilela através dos resultados obtidos na Prova Brasil. Neste artigo explorou-se técnicas de seleção de atributos e mineração de dados, identificando quais fatores impactam no IDEB das escolas municipais de Alagoas para posteriores estudos e reflexões na área da educação. Para tanto, utilizou-se dados do SAEB das escolas públicas municipais de Teotônio Vilela, conduzindo um estudo experimental, produzindo relevantes resultados na tarefa de identificação de atributos relevantes para apoiar os gestores educacionais.
LocalLearn: Um modelo U-Learning para auxílio no aprendizado do vocabulário de Inglês
Authors: Garcia da Silva Letícia , Francisco Rosemary , Barbosa Jorge
Published: February 2020

Aprendizes de idiomas geralmente enfrentam problemas de comunicação aodesejarem falar algo e não saberem a palavra ideal. Além disso, os contínuos avanços da tecnologia estão criando novas oportunidades para a aquisição de vocabulário de uma segunda língua por meio da tecnologia. Este artigo apresenta um modelo de aprendizado ubíquo para auxiliar os estudantes de inglês a aprender novos vocabulários. O estudo avaliou a viabilidade de apoiar o aprendizado de inglês no contexto do usuário. Os resultados indicam uma resposta favorável ao uso do contexto para auxiliar o usuário em sua aprendizagem. Foi alcançada uma aceitação de 78,66% para a percepção de utilidade e 96% para a percepção de facilidade de uso.
Análise do Uso da Cultura Maker em Contextos Educacionais: Revisão Sistemática da Literatura
Authors: Braga de Paula Bruna , De Oliveira Tiago , Bertini Martins Camila
Published: February 2020

A cultura maker tem como principal objetivo a mão na massa, possibilitar ainvenção e a solução de problemas; onde criar, modificar ou construir algum objeto é o foco. No contexto educacional a cultura maker busca explorar as atividades práticas em sala de aula, possibilitando a criação e resolução de problemas ao se construir protótipos e outros objetos que visam desenvolver diferentes habilidades. Dentro deste contexto, o objetivo do trabalho é apresentar uma visão geral dos estudos que abordam a cultura maker no meio educacional, utilizando uma Revisão Sistemática da Literatura (RSL). Para a obtenção dos estudos da RSL, foram utilizadas as bases de dados da ACM Digital Library, Emerald Insight, IEEE Xplore e Springer Link. De acordo com os resultados obtidos, verifica-se que o tema tem atraído a atenção da comunidade científica internacional, sendo a maior parte das pesquisas voltadas para o domínio de aprendizagem de Ciência e Tecnologia. A RSL aponta, também, para a necessidade de mais estudos relacionados à aplicação maker no ensino, o que propiciaria uma exploração e desenvolvimento de novas ferramentas e materiais, bem como a carência de novos instrumentos para medir a sua eficácia na educação.
CONCEPÇÕES DOCENTES SOBRE O USO DAS TECNOLOGIAS NA EDUCAÇÃO
Authors: Claudia Loureiro Ana , Costa Cavalcanti Carolina , Zukowsky Cristina
Published: February 2020

Este estudo objetivou relatar as concepções do professor sobre o uso das TIC na educação e a mudança dessas concepções após uma formação docente pautada na vivência de modelos pedagógicos, habilidades e organização que pudessem ser incorporados às práticas docentes. Para atendimento do objetivo do estudo foram comparadas as respostas de dois questionários aplicados a 36 docentes para verificar a utilização das TIC em seu cotidiano escolar. Os resultados indicaram que a maioria adota as tecnologias, mas ainda não sabe integrá-las à prática pedagógica. Após a formação recebida, as professoras apresentaram mudança de concepção e intenção de modificar a prática adotada, incorporando as TIC e as estratégias ativas em suas aulas.