bluuebunny/crossref_metadata_2025 huggingface dataset:
Visualidade e inventividade na obra de Ana Hatherly
Authors: Cirne Matthews
Published: August 2021

The article intends to discuss the visuality in the work of Ana Hatherly through plagiotropia, both in poetic and essayistic texts. It is an essencial experimental procedure for her revisitation to Portuguese baroque of the 17th and 18th centuries
O ensaísmo de Ana Hatherly: “na fronteira entre o diálogo e o duelo com tudo”
Authors: Klien Julia
Published: August 2021

One of the medullary aspects of Ana Hatherly’s poetics is its interest in the materiality of language, subjected to continuous investigations in the most varied forms. Each work seems to be a piece of the same incessant research and shows an attention to the performativity and physicality of writing, to the search for its most uneasy or suspensive – essayistic? – voltage. If the essayist, eminently experimental, sets up an “infinite game” and textualizes a “tactile tought” (Jean-Christophe Bailly), it is worth speculating on the configuration of an essayism in many of Hatherly’s poetic and visual experiences. Although the author also collects explicitly reflective texts, this essay starts from the hypothesis.
Sustainability in interior space organization of studio flats: Recommendations with examples of Northern Cyprus
Authors:   Graduate School of Applied Science, Near East University, Nicosia, Cyprus, Öncel Cansu , Turkan Zihni ,   Dpartment of Architecture, Faculty of Architecture, Near East University, Nicosia, Cyprus
Published: July 2021

The concept of housing began with the existence of people in this world with the need for sanctuary to isolate themselves from the physical environment and from other living creatures, and starting with the most primitive, hand-made places, evolved to the present. Different life cultures and different social needs, in parallel with the process of human development, resulted in various types of housing. Of these types of housing, Studio Houses, which provide the basic living functions within minimum space–mostly in a single space, have become a much-preferred house type by individuals living alone, and by students in the present day living conditions. The aim of this study is to examine the standard type interior organizations of the studio houses constructed in large numbers for students in North Cyprus, which is a university country. The study also aims at presenting design criteria for alternative studio-type houses with different fittings and interior designs meeting the needs of students studying in different branches of universities, thus having different lifestyles. Hence, after a literature review on the concept of housing and the history of housing, interior designs of studio houses of North Cyprus were analyzed, and classification was made according to their interior designs. Interviews were carried out with university students using these studio houses, thus establishing the spatial arrangements and fittings they need and assessing them. Although there are various studies related to the interior design of studio houses, the fact that there is no scientific research towards alternative interior designs for the specific needs of a different group of university students makes this study important.
Defining Patient-Oriented Natural Language Processing: A New Paradigm for Research and Development to Facilitate Adoption and Use by Medical Experts
Authors: Sarker Abeed , Al-Garadi Mohammed Ali , Yang Yuan-Chi , Choi Jinho , Quyyumi Arshed A , Martin Greg S
Published: August 2021

The capabilities of natural language processing (NLP) methods have expanded significantly in recent years, and progress has been particularly driven by advances in data science and machine learning. However, NLP is still largely underused in patient-oriented clinical research and care (POCRC). A key reason behind this is that clinical NLP methods are typically developed, optimized, and evaluated with narrowly focused data sets and tasks (eg, those for the detection of specific symptoms in free texts). Such research and development (R&D) approaches may be described as problem oriented, and the developed systems perform specialized tasks well. As standalone systems, however, they generally do not comprehensively meet the needs of POCRC. Thus, there is often a gap between the capabilities of clinical NLP methods and the needs of patient-facing medical experts. We believe that to increase the practical use of biomedical NLP, future R&D efforts need to be broadened to a new research paradigm—one that explicitly incorporates characteristics that are crucial for POCRC. We present our viewpoint about 4 such interrelated characteristics that can increase NLP systems’ suitability for POCRC (3 that represent NLP system properties and 1 associated with the R&D process)—(1) interpretability (the ability to explain system decisions), (2) patient centeredness (the capability to characterize diverse patients), (3) customizability (the flexibility for adapting to distinct settings, problems, and cohorts), and (4) multitask evaluation (the validation of system performance based on multiple tasks involving heterogeneous data sets). By using the NLP task of clinical concept detection as an example, we detail these characteristics and discuss how they may result in the increased uptake of NLP systems for POCRC.
Using the Behaviour Change Wheel Program Planning Model to Design Games for Health: Development Study
Authors: Robertson Michael C , Baranowski Tom , Thompson Debbe , Basen-Engquist Karen M , Swartz Maria Chang , Lyons Elizabeth J
Published: August 2021

Background

Games for health are a promising approach to health promotion. Their success depends on achieving both experiential (game) and instrumental (health) objectives. There is little to guide game for health (G4H) designers in integrating the science of behavior change with the art of game design.

Objective

The aim of this study is to extend the Behaviour Change Wheel program planning model to develop Challenges for Healthy Aging: Leveraging Limits for Engaging Networked Game-Based Exercise (CHALLENGE), a G4H centered on increasing physical activity in insufficiently active older women.

Methods

We present and apply the G4H Mechanics, Experiences, and Change (MECHA) process, which supplements the Behaviour Change Wheel program planning model. The additional steps are centered on identifying target G4H player experiences and corresponding game mechanics to help game designers integrate design elements and G4H objectives into behavioral interventions.

Results

We identified a target behavior of increasing moderate-intensity walking among insufficiently active older women and key psychosocial determinants of this behavior from self-determination theory (eg, autonomy). We used MECHA to map these constructs to intervention functions (eg, persuasion) and G4H target player experiences (eg, captivation). Next, we identified behavior change techniques (eg, framing or reframing) and specific game mechanics (eg, transforming) to help realize intervention functions and elicit targeted player experiences.

Conclusions

MECHA can help researchers map specific linkages between distal intervention objectives and more proximal game design mechanics in games for health. This can facilitate G4H program planning, evaluation, and clearer scientific communication.
Effects of temperature on growth performance, survival rate, digestive enzyme activities and physiological parameters of striped snakehead (Channa striata) at fry stage
Authors: Do Thi Thanh Huong , Nguyen Thi Kim Ha , Nguyen Tinh Em , Tang Minh Ky , Yasuaki Takagi , Nguyen Thanh Phuong
Published: July 2021

The effects of temperature on growth performance, survival rate, digestive enzymatic activities, and physiological responses of striped snakehead (Channa striata) at fry stage were evaluated. The study consisted of two trials including (1) determination of temperature threshold and (2) effects of different temperatures (24°C, 27°C (control), 30°C, 33°C and 36°C) on growth performance, survival rate, digestive enzyme activities and physiological parameters of striped snakehead fry stage for 90 days. The growth experiment was conducted in 500-L tank (250-L water) with triplicates. The stocking density was 300 individuals per tank. Striped snakehead at fry stage showed a high tolerance to temperature ranging from 10 to 40ºC. After 90 days, fish reared in 30°C performed the greatest weight and survival rate (13.1±3.12 g/fish and 15.5±4.63%, respectively). The number of red blood cells and hemoglobin concentrations increased with the increase in temperature. It was discovered that different temperatures (from 27 to 36°C) did not significantly influence the number of white blood cells, osmolality, and ion concentration of fish. Glucose and cortisol concentrations increased with temperature rises and peaked in fish reared at 36°C, while temperatures of 30oC and 33oC showed higher digestive enzyme activities. It proves that 30°C is the optimal level for striped snakehead fry rearing.
Effects of rotifer densities on larval performance of spotted scat (Scatophagus argus)
Authors: Le Quoc Viet , Ly Van Khanh , Duong Thi My Han , Tran Nguyen Duy Khoa , Kotani Tomonari , Tran Ngoc Hai
Published: July 2021

This study is aimed to determine the optimal rotifer feeding density for larviculture of spotted scat fish (Scatophagus argus). The experiment was randomly set up in triplicate with 5 treatments including 5, 10, 15, 20 and 25 rotifers/mL. The fish larvae with the initial body length and depth at 2,343 ± 110 µm and 812 ± 85µm, respectively, were stocked in 250-L tanks at 10 larva/L of density and 25‰ of salinity. After 21 days of rearing, the results showed that the larval growth were at 243 – 330 µm/day of DLG and 5.50 – 6.70 %/day of SGRL; 131 –204 µm/day of DDG and 7.20 – 8.93 %/day of SGRD, but no significant difference in larval growth performance was recorded among treatments (p>0.05). However, the highest survival rate of fish larvae (35.4-48.1%) was recorded in the treatments fed 5 and 10 rotifers/mL and was significantly higher than other treatments (p<0.05). The data demonstrated that spotted scat larvae fed effectively across as wide range of rotifer densities and the range at 5-10 rotifers/mL were suggested for the husbandry practices.
Intraspecific variations in morphology of swamp barb (Puntius brevis)
Authors: Le Ngoc Son , Duong Thuy Yen
Published: July 2021

Understanding inter-population variation and sexual differences in morphology is a fundamental part of taxonomic and biological research. External morphology of swamp barb (Puntius brevis) was compared between sexes and among three populations in the Mekong Delta, including O Mon-Can Tho (n=86), U Minh Thuong-Kien Giang (n=49) and U Minh Ha-Ca Mau (n=77). The results illustrate that color and countable parameters are similar in all populations. Nonetheless, 9 out of 20 morphometric indices are significantly different among three populations (P<0.05), where 6 indices are more important criteria to distinguish among swamp barb populations. Furthermore, the sexual dimorphism of this species is indicated in 16/20 morphometric indices consisting of 5 indices relating egg-carrying characteristics. In particular, the females have higher values of indices relating to abdomen and head parts while most of fin length indices are larger in males than in females. In sum, intraspecific variation in morphometrics of swamp barb is mainly due to sexual dimorphism rather than populations.
Status of using rope in purse seine fisheries in Viet Nam
Authors: Dinh Xuan Hung , Nguyen Phan Phuoc Long , Tran Xuan Lam
Published: July 2021

This study is to investigate the status of using rope in purse seine fisheries in Viet Nam based on surveyed data from 13 provinces/cities across country. Statistic data were taken randomly from 30 purse seine samples per each region of North, Middle, and South by pre-designed questionnaire with direct survey method of fishing gears combined with interview with the owners/captains. The results indicated that the initial constructing and annual replacing ropes of purse seine is mainly concentrated in the group of diameters from 10 - 20 mm. Up to 98% of Polypropylene (PP) material is used in Vietnamese purse seine. Float line and lead line are used the most ropes in purse seine. In purse seine fisheries, the annual additional rope is one quarter of the original amount of rope fitted. Purse seine in the Middle and the South is larger than that in the North of Viet Nam. The ratio of lengths between the float line and the lead line among the regions is different. The ratio of the main purse line with the lead line ranges from 1.1 to 1.75. Average life expectancy of main purse line is lowest in rope types of the purse seiners. The characteristics of the fishing grounds are different in these three regions, so the rope of purse seine is also different.
Chromosome status and yield characteristics of soybean (Glycine max L. (Merr)) in saline soil as affected by induced mutation
Authors: Simanjuntak Agus Pernando , Hanafiah Diana Sofia , Siregar Luthfi Aziz Mahmud
Published: August 2021

To fulfill the demand of soybeans, the expansion of the planting area can be one of the choices through the conversion of marginal land by utilizing suboptimal land, such as saline soil. One of the plant breeding techniques to obtain tolerant plants to salinity is the use of chemical mutations, such as colchicine. The study aimed to reveal the effect of salinity on the characters of soybean plants (mutated with colchicine) and the effect of colchicine on the number of chromosomes and ploidy level. This study was conducted from January to March 2020 and carried out in the plastic house of Faculty of Agriculture, Universitas Sumatera Utara. The experiment was arranged in a Randomized Block Design with salinity levels (0 dS.m-1, 2 dS.m-1, 4 dS.m-1, 6 dS.m-1) as treatments and consisted of ten replications in each treatment. The result showed that the soybean plants were not successfully induced by colchicine at a concentration of 0.04 % with soaking duration of 10 hours, as indicated by the number of chromosomes and analysis of ploidy level. The soybeans that had been induced were planted in saline soil. There were significant effects observed on the productive branch, number of filled pods, and the weight of seeds per plant. Colchicine treatment did not successfully affect the number of chromosomes of soybeans but had an impact on the chromosome pattern. In addition, the salinity treatment of 4 dS.m-1 significantly affected the number of filled pods compared to the treatment of 6 dS.m-1.
THE REPRESENTATION OF INDONESIAN WOMEN IN CONTEMPORARY TRAVEL WRITING: A STUDY OF DISCOURSE ON GENDER AND TRAVEL WRITING
Authors: Jaya Akmal , Pratama Mochamad Rizqi Adhi
Published: August 2021

This research aims to examine the representation of Indonesian women in contemporary travel writings. The rise of globalization has challenged the domination of discourses that tend to place Indonesian women in the subordinate position. However, the challenge does not warrant a symmetrical relation between genders, as it sometimes blurs the relation as a result of clashes between discourses. This study, then, provides an overview of how discourses have shaped the representation of Indonesian women by revealing images that appear explicitly and implicitly in travel stories. Using the Foucauldian discourse analysis approach allowed the writers to exclude subjects, objects, and meanings to discover a comprehensive web of image construction. This research found that Indonesian women’s representation is stuck in an ambiguous position as it strives to be an independent individual subject. Penelitian ini bertujuan untuk menjelaskan representasi perempuan Indonesia melalui cerita perjalanan kontemporer. Pada dasarnya, globalisasi telah menantang kuasa hegemoni wacana yang cenderung menempatkan perempuan Indonesia pada posisi kedua. Akan tetapi, hal tersebut tidak menjamin kesetaraan antara hubungan gender, melainkan terkadang menjadikannya semakin kabur sebagai konsekuensi adanya pertentangan antar wacana. Kajian ini memberikan gambaran bagaimana wacana membentuk representasi perempuan Indonesia dengan menunjukkan citra-citra yang hadir secara eksplisit maupun implisit dalam cerita perjalanan. Dengan menggunakan pendekatan analisis Foucauldian memberikan sebuah kemungkinan kepada kita untuk memisahkan antara subjek, objek dan makna dan untuk menemukan jaring-jaring konstruksi citra yang komprehensif. Penelitian ini menemukan bahwa representasi perempuan Indonesia terjebak dalam posisi yang ambigu yang tampaknya mencoba untuk hadir sebagai subjek independen.
GLOBAL OUTLOOK ON MEDICAL DEVICE INDUSTRY
Authors: LALWANI YASH , SUVARNA VASANTI
Published: August 2021

Medical devices assume a significant job in providing various healthcare services. The purpose of this article is tantamount to bring about the highlight key insights of the medical device industry and current innovative developments taking place, unique insights, and expectations for coming years from medical device industry professionals around the world. Global markets expect from the sturdiest growth, biggest regulatory challenges. The rising occurrence of acute diseases, regulatory requirements, and consistency in innovation is central point driving the medical device business sector development, later it is significant for the medical device industry to regularize and enhance the method to take into account the requirements of patients.
Relación entre el nivel de ansiedad y rendimiento académico en estudiantes de enfermería
Authors: Mosqueira-Soto C. , Poblete-Troncoso M.
Published: August 2021

Introducción: La ansiedad ante exámenes es un tipo de ansiedad de ejecución y puede afectar el rendimiento académico, en especial en los estudiantes de enfermería que sufren altos niveles de estrés.

Objetivo: Establecer la relación entre el nivel de ansiedad, el rendimiento académico y variables sociodemográficas en estudiantes de enfermería de la Universidad Católica del Maule.

Metodología: Estudio cuantitativo, descriptivo y de corte transversal. La muestra fue censal, de 94 estudiantes. Para la recolección de los datos se utilizaron dos instrumentos: de antecedentes sociodemográficos (edad, género, colegio de procedencia, lugar de origen y ocupación del estudiante); y el Cuestionario de Ansiedad frente a los Exámenes (CAEX). El rendimiento académico se obtuvo del Examen Clínico Objetivo Estructurado (OSCE por sus siglas en inglés). Para el análisis de los datos se usó T-Student y Anova.

Resultados: Se observó una relación significativa entre el rendimiento académico y el semestre que cursaban los estudiantes. Los estudiantes de los semestres más avanzados tuvieron mejor rendimiento (p= 0.015). El alumno que trabaja y estudia presentó mejor rendimiento en el examen OSCE con respecto al que sólo estudia (p= 0.027). El sexo femenino presentó diferencias significativas con el nivel ansiedad (p= 0.038).

Conclusión: Los niveles de ansiedad se encontraron entre los rangos bajos y medios, se sugiere mantenerlos para promover aprendizajes significativos. Resulta necesario analizar la planificación curricular para reestructurar las mallas curriculares y así apoyar a los estudiantes trabajadores al hacer compatible el trabajo con el estudio, con la finalidad de mejorar su calidad de vida.
A transdisciplinary approach to disease ecology: Emerging coronaviruses
Authors: Ojeda-Flores Rafael , Martínez-Duque Paola , Alonso Morales Rogelio , Corona-Barrera Enrique , Rico-Chávez Oscar , Suzán Gerardo
Published: August 2021

Humankind is currently facing the effects of an unparalleled pandemic that has impacted healthcare, social, and economic systems worldwide. Numerous studies have been published since the SARS-CoV-2 outbreak began in Wuhan, China. Most have focused on virology, epidemiology, pathogenesis, and therapeutic medicine, having been centered by reactive strategies to control the pandemic. Meanwhile, publications addressing the ecological, evolutionary, and anthropogenic drivers of virus emergence, and potential strategies to prevent future outbreaks have been sparse. Here, we highlight the necessity of complementary and transdisciplinary insight and methodologies from an integrated perspective to study emergent diseases. It is paramount to situate the consistently associated factors to understand the complexity of the current pandemic. Disease ecology can examine information to recognize the causes of emergence while appraising the role of interactions among pathogens, domestic animals, wildlife, and humans, integratively. Here we draw on a variety of disciplines and perspectives, from evolutionary biology, biogeography, ecology, molecular epidemiology and integrative health, to address the emergence of coronaviruses, with particular emphasis on SARS-CoV-2. We describe the process of the surfacing of zoonotic diseases, highlighting the interactions among wildlife, domestic animals, and humans, as well as the genetic, evolutionary, ecological, and anthropogenic processes that favor coronavirus epidemics and epizootics. We discuss specific results related to coronavirus investigations conducted in Mexico based on disease ecology methodologies. Finally, we describe alternative approaches for understanding and preventing future outbreaks and we suggest strategies to entice integrative and transdisciplinary research within the One Health/Ecohealth paradigm.
Design of Automated Screen-Printing Machine
Authors: Dedhia Utsav
Published: August 2021

India being one of the growing countries still uses manual screen-printing methods which involves using bare hands to spread the ink across and film and aligning the film with the print surface along with loading and unloading of material. This process is very time consuming and results in a decline in production rate. Automating these movements of the process help in enhancing quality of the print and an increase in the production rates and process time which in turn reduces labour cost.
A NOVEL ANALYTICAL METHOD FOR SIMULTANEOUS QUANTIFICATION OF DAPAGLIFLOZIN AND SITAGLIPTIN BY REVERSE PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY
Authors: Gupta Ajay
Published: July 2021

The Reverse phase HPLC method was developed for simultaneous determination of Dapagliflozin and Sitagliptin in single analytical method. Chromatographic separation was achieved on a Hypersil BDS C18 (250mmx4.6mm, 5µm) column applying an gradient elution based on potassium phosphate monobasic buffer pH (3.0) as mobile phase A while methanol and acetonitrile in the ratio of (60:40 v/v) as a mobile phase B with gradient program Time/Mobile phase A%/Mobile phase B% is as 0 min./55/45, 3 min./55/45, 9 min./20/80, 13 min.20/80, 15 min./55/45, 20 min./55/45. Validation parameters specificity, linearity, accuracy, precision and robustness have been observed to be desirable over the concentration ranges of 50-150 µg/ml for Dapagliflozin and Sitagliptin respectively. All the variables have been studied to optimize the chromatographic conditions. The optimized approach verified through validation and confirmed to be the intended purpose for the quality control of the mentioned drugs, as per ICH guidelines. For simultaneous quantification of Dapagliflozin and Sitagliptin, the developed method was found to be genuinely exact precise, accurate, linear, fast, and cost effective.
Transapical Aortic Valve Replacement Aided by Cardiopulmonary Bypass in a Patient with a Left Ventricular Thrombus
Authors: Qu Mingyu , Bao Li , Jing Sheng
Published: July 2021

Aortic stenosis is one of the most common degenerative valvular diseases
in the elderly. Transapical aortic valve implantation (TAVI) is an
innovative technique for high-risk patients with severe, symptomatic
aortic stenosis and multiple comorbidities. However, potential
obstruction to the left ventricular outflow tract, from a left
ventricular thrombus, poses significant patient risk and challenge for
the anesthetist. An 82-year-old man with these conditions underwent TAVI
and intracardiac thrombectomy under general anesthesia, combined with
cardiopulmonary bypass. We abandoned traditional surgical aortic valve
replacement and thrombectomy; a fast-track cardiac anesthesia strategy
was adopted. No complications were observed during recovery. Cardiac
function was normal upon follow-up 1 year, post-operatively. Transapical
aortic valve replacement aided by cardiopulmonary bypass, implemented
under Enhanced Recovery After Surgery (ERAS) strategy, is suitable for
high-risk patients under similar conditions. Strategies and equipment
should be maximized for analgesia, organ protection, and circulatory
homeostasis for perioperative safety and enhanced prognosis.
Autoimmune Overload: An atypical presentation of granulomatosis with polyangiitis in an adolescent with type-1 diabetes mellitus
Authors: Wardinger Jamie , Sussman Lauren , Litwa Breann , Irish Elizabeth , Foulke Llewellyn , Kaslovsky Robert
Published: July 2021

We report a case of granulomatosis with polyangiitis (GPA) in a
pediatric patient with a history of type 1 diabetes mellitus (T1DM)
after a somewhat unusual presentation. Antineutrophil cytoplasmic
antibody (ANCA)-associated vasculitides are a relatively rare entity in
the general population, and are even less common amongst the pediatric
population. Our patient’s chronic history of vague and systemic symptoms
paired with social and environmental stressors contributed to her
convoluted picture and late diagnosis. In addition, her T1DM adds an
interesting element to her case, begging the question of whether her
propensity for autoimmune conditions played a role in the development of
this disease. With this case, we hope to increase clinician level of
suspicion and promote early diagnosis and treatment for future pediatric
patients.
Pine defense responses to eggs of an herbivorous sawfly are elicited by an annexin-like protein
Authors: Hundacker Janik , Bittner Norbert , Weise Christoph , Bröhan Gunnar , Varama Martti , Hilker Monika
Published: August 2021

Known elicitors of plant defenses against eggs of herbivorous insects
are low-molecular-weight organic compounds associated with the eggs.
However, previous studies provided evidence that also proteinaceous
compounds present in secretion associated with eggs of the herbivorous
sawfly Diprion pini can elicit defensive responses in Pinus sylvestris.
Pine responses induced by the proteinaceous secretion are known to
result in enhanced emission of (E)-β-farnesene, which attracts egg
parasitoids killing the eggs. Here, we aimed to identify the
defense-eliciting protein and elucidate its function. After isolating
the defense-eliciting protein from D. pini egg secretion by
ultrafiltration and gel electrophoresis, we identified it by MALDI-ToF
mass spectrometry as an annexin-like protein, which we named
“diprionin”. Further GC-MS analyses showed that pine needles treated
with heterologously expressed diprionin released enhanced quantities of
(E)-β-farnesene. Our bioassays confirmed attractiveness of
diprionin-treated pine to egg parasitoids. Expression of several pine
candidate genes involved in terpene biosynthesis and regulation of ROS
homeostasis was similarly affected by diprionin and natural sawfly egg
deposition. However, the two treatments had different effects on
expression of pathogenesis related genes (PR1, PR5). Diprionin is the
first egg-associated proteinaceous elicitor of indirect plant defense
against insect eggs described so far.
Recommendations by the ClinGen Rett/Angelman-like Expert Panel for Gene-specific Variant Interpretation Methods
Authors: McKnight Dianalee , Bean Lora , Karbassi Izabela , Beattie Katelynn , Bienvenu Thierry , Bonin Hope , Fang Ping , Christodoulou John , Friez Michael , Helgeson Maria , Krishnaraj Rahul , Meng Linyan , Mighion Lindsey , Neul Jeffrey , Percy Alan , Ramsden Simon , Zoghbi Huda Y. , Das Soma
Published: August 2021

The genes MECP2, CDKL5, FOXG1, UBE3A, SLC9A6, and TCF4 present unique
challenges for current ACMG/AMP variant interpretation guidelines. To
address those challenges, the Rett and Angelman-like Disorders Variant
Curation Expert Panel (Rett/AS VCEP) drafted gene-specific
modifications. A pilot study was conducted to test the clarity and
accuracy of using the customized variant interpretation criteria.
Multiple curators obtained the same interpretation for 78 out of the 87
variants (~90%), indicating appropriate usage of the
modified guidelines the majority of times by all the curators. The
classification of 13 variants changed using these criteria
specifications compared to when the variants were originally curated and
as present in ClinVar. Many of these changes were due to internal data
shared from laboratory members however some changes were because of
changes in strength of criteria. There were no two step classification
changes and only 1 clinically relevant change (Likely pathogenic to
VUS). The Rett/AS VCEP hopes that these gene-specific variant curation
rules and the assertions provided help clinicians, clinical
laboratories, and others interpret variants in these genes but also
other fully penetrant, early-onset genes associated with rare disorders.
Cardiogenic Shock & Machine Learning: A Systematic Review on Prediction Through Clinical Decision Support Softwares
Authors: Aleman Rene , Patel Sinal , Sleiman Jose , Navia Jose , Sheffield Cedric , Brozzi Nicolas
Published: August 2021

Background & Aim Cardiogenic shock (CS) withholds a significantly high
mortality rate between 40-60% despite advances in diagnosis and
medical/surgical intervention. To-date, machine learning(ML) is being
implemented to integrate numerous data to optimize early diagnostic
predictions and suggest clinical courses. This systematic review
summarizes the area under the curve (AUC) receiver operating
characteristics (ROC) accuracy for the early prediction of CS. Methods A
systematic review was conducted within databases of PubMed,
ScienceDirect, Clinical Key/MEDLINE, Embase, GoogleScholar, and
Cochrane. Cohort studies that assessed accuracy of early detection of CS
using ML software were included. Data extraction was focused on AUC-ROC
values directed towards early detection of CS. Results A total of 943
studies were included for systematic review. From the reviewed studies,
2.2% (N=21) evaluated patient outcomes, of which 14.3% (N=3) were
assessed. The collective patient cohort (N=698) consisted of 314(45.0%)
females, with an average age and body mass index (BMI) of 64.1years and
28.1kg/m2, respectively. Collectively, 159 (22.8%) mortalities were
reported following early CS detection. Altogether, the AUC-ROC value was
0.82 (alfa=0.05), deeming it of superb sensitivity and specificity.
Conclusions From the present comprehensively gathered data, this study
accounts the use of ML software for the early detection of CS in a
clinical setting as a valid tool to predict patients at risk of CS. The
complexity of ML and its parallel lack of clinical evidence implies that
further prospective randomized control trials are needed to draw
definitive conclusions prior to standardizing use of these technologies.
Eastern red-backed salamanders: A comprehensive review of an undervalued model in evolution, ecology, & behavior
Authors: Fisher-Reid M. Caitlin , Grayson Kristine , Grouleff Sara R. , Hair Madelyn A. , Matlaga Tanya J. Hawley , Ireland Angelina K. , Mead Louise S. , John Alyssa St , Starr Meigan , Sterrett Sean C. , Streeter Kody N.
Published: August 2021

What makes a model organism? Identifying the qualities of a model
organism has been given a great deal of attention in the biomolecular
sciences, but less so in the fields of evolution, ecology, and behavior
(EEB). In EEB, biotic and abiotic variation are features to understand,
not bugs to get rid of, and EEB scientists often select organisms to
study which best suit the scientific question at hand. Successful EEB
model organisms can be studied at multiple biological scales and have a
wealth of accumulated knowledge on which current research programs
build. A recent call within EEB to invest in the inclusive development
of diverse model systems and scientists has led us to evaluate the
standing of the widespread, abundant, terrestrial salamander we study,
the eastern red-backed salamander (Plethodon cinereus). We first
look at salamanders as EEB models more generally, to determine
where P. cinereus fits in this broader context. We next present a
comprehensive review of the literature on the eastern red-backed
salamander (Plethodon cinereus) since the last comprehensive
review was completed in 1998. The core of our paper reviews 410 recent
studies and highlights inconsistencies, gaps in our knowledge, and
future directions in the context of the 1998 review. Finally, we present
a collaborative research network, SPARCnet, as a nascent infrastructure
for continued research on P. cinereus. Here, we especially
discuss how this type of infrastructure can be broadly applied not just
to other salamanders, but to other model systems, so that the future of
EEB research may benefit from models which accurately represent, in
Darwin’s words, “endless forms most beautiful and most wonderful.”
A general meta-ecosystem model to predict ecosystem function at landscape extents
Authors: Harvey Eric , Marleau Justin , Gounand Isabelle , Leroux Shawn , Firkowski Carina Rauen , Altermatt Florian , Blanchet F. Guillaume , Cazelles Kevin , Chu Cindy , D'Aloia Cassidy , Donelle Louis , Gravel Dominique , Guichard Frédéric , McCann Kevin , Ruppert Jonathan , Ward Colette , Fortin Marie-Josee
Published: August 2021

The integration of meta-ecosystem processes over large spatial extent is
critical to predicting whether and how global changes might impact
biodiversity and ecosystem functions. Yet, there remains an important
gap in meta-ecosystem models to predict multiple ecosystem functions
(e.g., carbon sequestration, elemental cycling, trophic efficiency)
across different ecosystem types (e.g., terrestrial-aquatic,
benthic-pelagic). We derive a generic meta-ecosystem model to predict
ecosystem function at landscape extents by integrating the spatial
dimension of natural systems as spatial networks of different habitat
types connected by cross-ecosystem flows of materials and organisms.
This model partitions the physical connectedness of ecosystems from the
spatial flow rates of materials and organisms, allowing the
representation of all types of connectivity across ecosystem boundaries
as well as the interaction(s) between them. The model predicts that
cross-ecosystem flows maximize the realization of multiple functions at
landscape extent. Spatial flows, even the ones that significantly reduce
the overall amount of nutrients in the meta-ecosystem, can reallocate
nutrients to more efficient ecosystems, leading to greater levels of
productivity at both local and regional scales. This ‘cross-ecosystem
efficiency hypothesis’ is a general and testable hypothesis emphasizing
the complementarity and interconnectedness among ecosystems and the
importance of addressing ecosystem diversity for meta-ecosystem
function.
Dieta líquida rica en ácidos grasos, estrategia de alimentación para cerdos en el trópico
Authors: Bolívar Sierra Andrés Felipe
Published: August 2021

El uso de diferentes tecnologías y recursos relacionados con la alimentación de los cerdos se debe enfocar en un mejoramiento continuo de las condiciones de los animales, que satisfaga sus requerimientos nutricionales (en cantidad y calidad) y les permita un buen desempeño, lo cual se evidencia en los parámetros productivos y reproductivos, como también en la salud y el bienestar del hato. La nutrición es uno de los pilares que sustenta la producción de cerdos, ya sea para garantizar el producto final de buena calidad o por tratarse del componente de mayor peso en el costo final de producción. Los principales componentes que suplen los requerimientos energéticos de los cerdos son carbohidratos y lípidos. EI maíz es la principal fuente de energía utilizada en la alimentación porcina, contiene niveles de energía digestible y metabolizable de 3.5 y 3.3 Mcal/kg, respectivamente. Mientras que las grasas y aceites aportan 9.0 a 9.5 Mcal/kg de energía digestible, siendo consideradas como una muy buena fuente de energía, pero estos componentes lipídicos son adicionados tan solo en niveles de 3 a 5% en la dieta. Una diferencia que existe entre los componentes de la dieta se debe al incremento calórico (IC), representado por el aumento de la producción de calor después del consumo de alimento por parte del animal. Por otro lado, un problema muy común en el uso de grasas y aceites en la formulación de dietas es la rancidez. Factores como temperatura, enzimas, luz e iones metálicos pueden influenciar la formación de radicales libres que en contacto con oxígeno molecular lleva a la formación de un peróxido. La reacción con otra molécula oxidable induce la formación de hidroperóxido y otro radical libre. Los hidroperóxidos dan origen a dos radicales libres capaces de atacar otras moléculas y formar más radicales libres. Al romperse las moléculas formadas, generan productos de peso molecular más bajo como aldehídos, cetonas, alcoholes y esteres, los cuales son volátiles y responsables por la rancificación. Cuando la grasa está sujeta a oxidación y se torna rancia, reduce su palatabilidad y puede ser causa de problemas nutricionales y digestivos.
Chronic Antidiabetic Actions of Leptin: Evidence from Parabiosis Studies for a CNS-Derived Circulating Antidiabetic Factor
Authors: Silva Alexandre A. da , Hall John E. , Dai Xuemei , Wang Zhen , Salgado Mateus C. , Carmo Jussara M. do
Published: August 2021

We used parabiosis to determine whether the central nervous system
(CNS)-mediated antidiabetic effects of leptin are mediated by release of a
brain-derived circulating factor(s). Parabiosis was surgically induced at 4
weeks of age and an intracerebroventricular (ICV) cannula was placed in the lateral
cerebral ventricles at 12 weeks of age for ICV infusion of leptin or saline
vehicle. Ten days after surgery, food intake, body weight and blood glucose
were measured for 5 consecutive days and insulin-deficiency diabetes was
induced in all rats by a single streptozotocin (STZ) injection (40 mg/kg). Five
days after STZ injection, leptin or vehicle was infused ICV for 7 days,
followed by 5-day recovery period. STZ increased blood glucose and food intake.
Chronic ICV leptin infusion restored normoglycemia in leptin-infused rats while
reducing blood glucose by ~27% in conjoined vehicle-infused rats. This glucose
reduction was caused mainly by decreased hepatic gluconeogenesis. Chronic ICV
leptin infusion also reduced net cumulative food intake and increased GLUT4
expression in skeletal muscle in leptin/vehicle compared to vehicle/vehicle
conjoined rats. These results indicate that leptin’s CNS-mediated antidiabetic
effects are mediated, in part, by release into the systemic circulation of a
leptin-stimulated factor(s) that enhances glucose utilization and reduces liver
gluconeogenesis.
Modele architektoniczne narzędziem włoskiej praktyki projektowania i ich stosowanie w dawnej Rzeczypospolitej
Authors: Dettloff Paweł
Published: July 2021

Artykuł poświęcony jest wyjaśnieniu pojęcia modelu architektonicznego, jego genezy i praktyki zastosowania na ziemiach polskich. Zwyczaj ich wykonywania wprowadzili w Rzeczypospolitej włoscy architekci, a ugruntować mogli budowniczowie z krajów niemieckich. Modele były znane i wykonywane od XVI w., zapewne znacznie częściej niż wskazują na to nieliczne, zachowane do dziś egzemplarze. Te ostatnie pochodzą z XVIII w., a przedstawiają hełmy wież kolegiaty św. Anny w Krakowie, fasadę katedry poznańskiej oraz drewniany kościół w Szalowej.
A ASSISTÊNCIA JUDICIÁRIA INTEGRAL E GRATUITA E O PAPEL DO ADVOGADO NAS QUESTÕES DE PRO BONO
Authors: Correia Italo Schelive , Carvalho Leandro Couto , Rodrigues Deivison de Castro
Published: August 2021

A resposta judicial à solução dos conflitos é o meio mais expressivo para a solução dos conflitos. O acesso ao Poder judiciário é uma garantia constitucional e que também pode ser exercida por pessoas carentes, por meio da Defensoria Pública, da atuação em nome próprio, nos termos da lei do Juizado Especial, mas também por meio de advogado privado como pro bono, que é o advogado privado que atua gratuitamente. O estudo teve por objetivo pesquisar e discurso sobre a importância da Justiça Integral e Gratuita aos hipossuficientes na forma da Lei, identificaar o papel fundamental da Defensoria Pública na assistência aos mais carentes, bem como o Papel dos advogados quando não havia Defensoria cuja importância continua até os dias atuais, porque mesmo com o advento da criação dos Defensores Públicos, o advogado tem o direito fornecer assistência jurídica gratuita em casos pro bono, que é o foco do estudo. O estudo foi desenvolvido por meio de método dedutivo, com base em pesquisa bibliográfica exploratóriaem legislação, livros e dados públicos. Dentre as principais considerações, ficou constatado a importância da assistência judiciária integral e gratuita para a defesa jurídica dos mais carentes e também a importância e o papel do advogado privado em atuação pro bono. Também foi demonstrada a importância da atuação da Defensoria Pública e a possibilidade de atuação do jurisdicionado em nome próprio, nos termos da Lei 9.099/95.
Reconhecimento da dignidade da pessoa humana furto de energia elétrica e água, estado de necessidade resenha da apelação criminal N.º 0003175-43.2009.8.26.0145
Authors: Da Silva Marco Antonio Marques , Furtado Régis Munari
Published: August 2021

FURTO DE ENERGIA ELÉTRICA E ÁGUA, ESTADO DE NECESSIDADE E RECONHECIMENTO DA DIGNIDADE DA PESSOA HUMANA: RESENHA DA APELAÇÃO CRIMINAL N.º 0003175-43.2009.8.26.0145
Cystic Lymphangioma of the Pancreas: About A Case and Literature Review
Authors: Kouame Dr Kouassi Armel Serge , El Mehdi Dr Aboulfeth , Mohamed Dr Bouzroud , Mohamed Pr Najih , Hakim Pr Kaoui , Ahmed Pr Bounaim
Published: August 2021

Cystic lymphangioma is a rare malformative benign tumour of the lymph vessels, its histogenesis is still hypothetical. This tumour is mainly found in child’s neck and axillary, the pancreatic location remains exceptional and represents less than 1% of whole lymphangiomas, and occurs more frequently in women and especially in the left pancreas.
Its clinical presentation is polymorphic; however, the diagnosis can’t be specifically evoked by imaging and requires therefore histological confirmation. Surgery remains the only curative treatment.
We report in this work the case of an incidentally discovered cystic lymphangioma of the pancreatic tail in a 58-year-old woman. The histological study of the surgical specimen concluded on a benign cystic lymphangioma.
On later surgical outcomes, the patient developed a pseudokyst of the remaining pancreas and today she has not had any recurrences.
The aim of this article is to share our experience in the management of this case and to review the clinical and therapeutic aspects of this rare pathology.
Hodgkin Lymphoma in Multifocal Unilateral Breast Cancer: Is it Simple Coincidence?
Authors: Al-Rashdi Aya , Al Qassabi Badryia , Al Ajmi Radiya , Al Aghbari Suad
Published: August 2021

Breast cancer (BC) and malignant lymphoma (ML) each of them are considered as a common primary malignant disease worldwide. Synchronous occurrences of BC and ML are rare. We are presenting a case of a 34 year old patient with breast cancer and Hodgkin lymphoma detected in non-sentinel lymph node biopsy. This represents a rare case of coexistence of dual malignancies. We review the literature and discuss possible etiologies for these synchronous tumors.
POTENSI GELATIN DARI BERBAGAI SUMBER DALAM MEMPERBAIKI KARAKTERISTIK MARSHMALLOW: REVIEW
Authors: Cahyaningrum Rafida , Safira Kesya Khansa , Lutfiyah Gina Nazilah , Zahra Sarah Izdihar , Rahasticha Aza Aisyah
Published: July 2021

Marshmallow merupakan jenis makanan ringan yaitu sejenis permen lunak (soft candy) dengan salah satu bahan utama pembuatannya adalah gelatin. Gelatin merupakan hidrokoloid yang memiliki sifat dapat melakukan perubahan secara reversible atau dapat kembali ke keadaan semula dari bentuk sol menjadi gel atau gel menjadi sol, yang pada pembuatan marshmallow berperan penting sebagai gelling agent. Tujuan dari penelitian ini untuk mengetahui potensi penggunaan gelatin dalam memperbaiki karakteristik marshmallow. Dari hasil, didapatkan bahwa gelatin dapat mempengaruhi karakteristik dari marshmallow, yaitu kadar air, kadar abu, kadar vitamin C, tekstur dan elastisitas, tetapi tidak dengan kadar gula reduksi nya. Karakteristik marshmallow yang dihasilkan juga bergantung pada banyaknya atau proporsi gelatin yang ditambahkan.
Kesiapan Perpustakaan dalam Implementasi Teknologi Informasi (Studi Kasus Perpustakaan UIN Sumatera Utara Medan)
Authors: Habiburrahman Habiburrahman
Published: August 2021

This research aims to determine the level of ereadiness at Library of UIN Sumatra Utara Medan. This research uses mix method concurrent triangulation model. The instrument of e readiness used in this research was developed by Mutula & Brakel. Data collection techniques used in this research are questionnaire to get the quantitative data and deep interview and observation to get the qualitative data. Population which become subject in this research is 16 people who are library staff at Library of UIN Sumatera Utara Medan. The sample in this research is determined by saturation sampling technique to get quantitative data and purposive sampling teechnique to get qualitative data. Quantitative analysis showed that in the enterprise readiness segment, the score was 2.93 which means ready, in human resource readiness segment obtained the score of 2.63 which is categorized as ready but has very low e-readiness score because the library doesn’t have sufficient profesional staff, in the information readiness segment the score was 2.89 which is categorized ready, in ICT readiness segment obtained 2.94 which is categorized ready, while in the of external environment readiness segment obtained the score of 2.88 which is also in the ready category. While the qualitative analysis got the result that the ICT infrastructure is quite ready for the implementation of information technology altough there are still component that have not been feasible which is the quality of the internet WiFi network for users. In addintion, in terms of professional human resources, the library doesn’t have edaquate experts. For that it is necessary to add some profesionals in the field of information technology also the provision of continuous training to the staff and librarians by involving them in professional trainings so that the librarians and library staff have sufficient ability to handle the problems that occur in the implementation of information technology.
Pengelolaan Arsip Sejarah Di Perpustakaan Daerah Lampung
Authors: Carolline Veronica , Sari Novita , Putri Sherly Armelia , Sagita Rahmad Dwi
Published: August 2021

Pengelolahan arsip di Perpustakaan Daerah Lampung memiliki peranan yang penting bagi seluruh kegiatan di instansi terutama mengenai dokumen yang berhubungan dengan sejarah daerah maupun perjalanan sebuah organisasi yang tidak hanya disim=[pan begitu saja tetapi juga perlu memiliki tata aturan dalam pengelolaannya. Secara tidak langsung manajemen pengelolaan arsip diperlukan sebagai suatu sistem pengelolaan arsip yang menjadi usaha dalam penyediaan informasi pada saat dibutuhkan. Penelitian ini bertujuan untuk mengetahui bagaimana sistem manajemen pengelolaan arsip di Perpustakaan Daerah Provinsi Lampung. Jenis penelitian yang digunakan adalah penelitian kualitatif dengan pendekatan deskriptif. Teknik pengumpulan data melalui wawancara, observasi, dan studi kepustakaan. Mengingat pentingnya arsip, maka diperlukan sebuah sistem pengelolaan arsip sebagai salah satu usaha dalam penyediaan informasi di masa mendatang.