bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring Embodied Experience via Videoconferencing: A Method for Body Mapping Online
Authors: Vaughan Priya , Dew Angela , Ngo Akii , Blayney Alise , Boydell Katherine
Published: December 2022

Faced with a series of COVID-19 related lockdowns in Australia across 2020 and 2021, and anxious about the safety of our research participants, we developed a novel approach to body mapping, an arts-based research method typically undertaken in-person. We produced a facilitated body mapping workshop hosted via an online videoconferencing platform. Workshops brought together 29 participants with disability, mental distress and/or refugee background who used body mapping to represent their embodied experiences of stigma and discrimination. These workshops generated rich data, and participants reported a high level of satisfaction with the process. In this paper we describe our novel approach to body mapping, and share practical tips for others who wish to undertake body mapping remotely. We outline strengths associated with this method: increased accessibility, enhanced connection between participants, the formation of a space to explore challenging subject matter, the production of rich data, and the creation of diverse body maps. We also discuss shortcomings and challenges which those considering the method should be aware of: increased logistical burden, demands related to space, IT difficulties, the danger of over-sharing, and diminished cohort sizes. To our knowledge, this is the first paper to report on body mapping facilitated via web-based workshops. Here, we seek to provide practical advice and useful insights for others hoping to utilise body mapping online.
CTSK variant implicated in suspected pyknodysostosis in a domestic cat
Authors: Lyraki Maria , Hibbert Angie , Langley-Hobbs Sorrel , Lait Philippa , Buckley Reuben M , Warren Wesley C , Lyons Leslie A ,   99 Lives Consortium
Published: December 2022

Case summary

A 9-month-old entire male domestic longhair cat presented with a history of pathological fractures, chronic musculoskeletal pain and poor growth. Multiple facial and skeletal abnormalities were identified on physical examination and advanced imaging (CT and radiographs). A variant in CTSK was identified in the affected cat following whole-exome sequencing (WES). The cat was managed symptomatically with diet, environmental modifications and analgesia.

Relevance and novel information

This is the first report of a cat with a similar clinical presentation and genetic variant to the hereditary human genetic disorder pyknodysostosis. In this case, WES was performed, which often facilitates the diagnosis of various hereditary disorders (ie, a conceptual framework for practicing feline genomic medicine). Despite the severe skeletal and appendicular abnormalities described, the cat was alive more than 2 years after its initial presentation.
llperm: a permutation of regressor residuals test for microbiome data
Authors: Viljanen Markus , Boshuizen Hendriek
Published: December 2022

Background

Differential abundance testing is an important aspect of microbiome data analysis, where each taxa is fitted with a statistical test or a regression model. However, many models do not provide a good fit to real microbiome data. This has been shown to result in high false positive rates. Permutation tests are a good alternative, but a regression approach is desired for small data sets with many covariates, where stratification is not an option.

Results

We implement an R package ‘llperm’ where the The Permutation of Regressor Residuals (PRR) test can be applied to any likelihood based model, not only generalized linear models. This enables distributions with zero-inflation and overdispersion, making the test suitable for count regression models popular in microbiome data analysis. Simulations based on a real data set show that the PRR-test approach is able to maintain the correct nominal false positive rate expected from the null hypothesis, while having equal or greater power to detect the true positives as models based on likelihood at a given false positive rate.

Conclusions

Standard count regression models can have a shockingly high false positive rate in microbiome data sets. As they may lead to false conclusions, the guaranteed nominal false positive rate gained from the PRR-test can be viewed as a major benefit.
Healthcare professionals’ knowledge of the systematic ABCDE approach: a cross-sectional study
Authors: Schoeber Nino H. C. , Linders Marjolein , Binkhorst Mathijs , De Boode Willem-Pieter , Draaisma Jos M. T. , Morsink Marlies , Nusmeier Anneliese , Pas Martijn , van Riessen Christine , Turner Nigel M. , Verhage Rutger , Fluit Cornelia R. M. G. , Hogeveen Marije
Published: December 2022

Background

The Airway, Breathing, Circulation, Disability and Exposure (ABCDE) approach is a universal, priority-based approach for the assessment and treatment of critically ill patients. Although the ABCDE approach is widely recommended, adherence in practice appears to be suboptimal. The cause of this non-compliance is unknown. As knowledge is a prerequisite for adherence, the aim of this study was to assess healthcare professionals’ knowledge of the ABCDE approach.

Methods

A cross-sectional study was conducted at the Radboud University Medical Center, the Netherlands. A digital multiple-choice assessment tool of the ABCDE approach was developed by an expert panel through a mini-Delphi method and validated by performing test item statistics and an expert-novice comparison. The validated test was sent to healthcare professionals (nurses, residents and medical specialists) of the participating departments: Anaesthesiology, Paediatrics, Emergency Department and the Neonatal, Paediatric and Adult Intensive Care Units. Primary outcome was the test score, reflecting individual level of knowledge. Descriptive statistics, regression analysis and ANOVA were used.

Results

Test validation showed a Cronbach’s alpha of 0.71 and an expert-novice comparison of 91.9% (standard deviation (SD) 9.1) and 72.4% (15.2) respectively (p < 0.001). Of 954 eligible participants, 240 filled out the questionnaire. The mean (SD) test score (% of correct answers) was 80.1% (12.2). Nurses had significantly lower scores (74.9% (10.9)) than residents (92.3% (7.5)) and medical specialists (88.0% (8.6)) (p < 0.001). The Neonatal Intensive Care Unit (75.9% (12.6)) and Adult Intensive Care Unit (77.4% (11.2)) had significantly lower scores than Paediatric Intensive Care Unit (85.6% (10.6)), Emergency Department (85.5% (10.4)) and Anaesthesiology (85.3% (10.6)) (p < 0.05). Younger participants scored higher than older participants (−0.30% (-0.46;-0.15) in test score/year increase in age).

Conclusion

Scores of a validated knowledge test regarding the ABCDE approach vary among healthcare professionals caring for critically ill patients. Type of department, profession category and age had a significant influence on the test score. Further research should relate theoretical knowledge level to clinical practice. Tailored interventions to increase ABCDE-related knowledge are recommended.
Normal spirometry prediction equations for the Iranian population
Authors: Sahebi Leyla , Rahimi Besharat , Shariat Mamak , Mousavy Seyyed Hosein , Hosseini Mohsen
Published: December 2022

Background

This study aimed to establish normative spirometric equations in a healthy population of Iranian children and adults, and compare these equations with those developed by the Caucasian Global Lung Initiative (GLI) for the first time.

Methods

Spirometric data from healthy Iranian aged 4–82 years sampled in 2019 were used to derive reference equations using the generalized additive model for location (mu), shape (lambda), and scale (sigma).

Results

A total of 418 females and 204 males were included in the study. Applying the GLI standards for the Iranian population resulted from the Z scores of FEV1, FVC, FEV1/FVC, and FEF25−75% was not different from zero. Based on the newly calculated LLN, eleven individuals showed significant values below the LLN for FEV1/FVC. In all age groups, this frequency was less than 5%, except for men over 70 years of age, which was 12.5%. There are significant differences between new data and GLI for Caucasian data.

Conclusion

It is recommended that the values and equations generated from this study should be used by physicians and technicians in their routine practice for the diagnosis and assessment of pulmonary disorders.
Stepwise reduction of bone mineral density increases the risk of cage subsidence in oblique lumbar interbody fusion patients biomechanically: an in-silico study
Authors: Yang Zhi-Qiang , Cai Ping , Li Jing-Chi , Wang Xian-Di , Xie Tian-Hang , Pu Xing-Xiao , Lin Run , Zeng Jian-Cheng , Song Yue-Ming
Published: December 2022

Background

Cage subsidence causes poor prognoses in patients treated by oblique lumbar interbody fusion (OLIF). Deterioration of the biomechanical environment initially triggers cage subsidence, and patients with low bone mineral density (BMD) suffer a higher risk of cage subsidence. However, whether low BMD increases the risk of cage subsidence by deteriorating the local biomechanical environment has not been clearly identified.

Methods

OLIF without additional fixation (stand-alone, S-A) and with different additional fixation devices (AFDs), including anterolateral single rod screws (ALSRs) and bilateral pedicle screws (BPSs) fixation, was simulated in the L4-L5 segment of a well-validated finite element model. The biomechanical effects of different BMDs were investigated by adjusting the material properties of bony structures. Biomechanical indicators related to cage subsidence were computed and recorded under different directional moments.

Results

Overall, low BMD triggers stress concentration in surgical segment, the highest equivalent stress can be observed in osteoporosis models under most loading conditions. Compared with the flexion-extension loading condition, this variation tendency was more pronounced under bending and rotation loading conditions. In addition, AFDs obviously reduced the stress concentration on both bony endplates and the OLIF cage, and the maximum stress on ALSRs was evidently higher than that on BPSs under almost all loading conditions.

Conclusions

Stepwise reduction of BMD increases the risk of a poor local biomechanical environment in OLIF patients, and regular anti-osteoporosis therapy should be considered an effective method to biomechanically optimize the prognosis of OLIF patients.
Daily dose evaluation based on corrected CBCTs for breast cancer patients: accuracy of dose and complication risk assessment
Authors: Hamming Vincent C. , Andersson Sebastian , Maduro John H. , Langendijk Johannes A. , Both Stefan , Sijtsema Nanna M.
Published: December 2022

Objectives

The goal of this study is to validate different CBCT correction methods to select the superior method that can be used for dose evaluation in breast cancer patients with large anatomical changes treated with photon irradiation.

Materials and method

Seventy-six breast cancer patients treated with a partial VMAT photon technique (70% conformal, 30% VMAT) were included in this study. All patients showed at least a 5 mm variation (swelling or shrinkage) of the breast on the CBCT compared to the planning-CT (pCT) and had a repeat-CT (rCT) for dose evaluation acquired within 3 days of this CBCT. The original CBCT was corrected using four methods: (1) HU-override correction (CBCTHU), (2) analytical correction and conversion (CBCTCC), (3) deep learning (DL) correction (CTDL) and (4) virtual correction (CTV). Image quality evaluation consisted of calculating the mean absolute error (MAE) and mean error (ME) within the whole breast clinical target volume (CTV) and the field of view of the CBCT minus 2 cm (CBCT-ROI) with respect to the rCT. The dose was calculated on all image sets using the clinical treatment plan for dose and gamma passing rate analysis.

Results

The MAE of the CBCT-ROI was below 66 HU for all corrected CBCTs, except for the CBCTHU with a MAE of 142 HU. No significant dose differences were observed in the CTV regions in the CBCTCC, CTDL and CTv. Only the CBCTHU deviated significantly (p < 0.01) resulting in 1.7% (± 1.1%) average dose deviation. Gamma passing rates were > 95% for 2%/2 mm for all corrected CBCTs.

Conclusion

The analytical correction and conversion, deep learning correction and virtual correction methods can be applied for an accurate CBCT correction that can be used for dose evaluation during the course of photon radiotherapy of breast cancer patients.
Stool energy density is positively correlated to intestinal transit time and related to microbial enterotypes
Authors: Boekhorst Jos , Venlet Naomi , Procházková Nicola , Hansen Mathias L. , Lieberoth Christian B. , Bahl Martin I. , Lauritzen Lotte , Pedersen Oluf , Licht Tine Rask , Kleerebezem Michiel , Roager Henrik M.
Published: December 2022

Background

It has been hypothesised that the gut microbiota causally affects obesity via its capacity to extract energy from the diet. Yet, evidence elucidating the role of particular human microbial community structures and determinants of microbiota-dependent energy harvest is lacking.

Results

Here, we investigated whether energy extraction from the diet in 85 overweight adults, estimated by dry stool energy density, was associated with intestinal transit time and variations in microbial community diversity and overall structure stratified as enterotypes. We hypothesised that a slower intestinal transit would allow for more energy extraction. However, opposite of what we expected, the stool energy density was positively associated with intestinal transit time. Stratifications into enterotypes showed that individuals with a Bacteroides enterotype (B-type) had significantly lower stool energy density, shorter intestinal transit times, and lower alpha-diversity compared to individuals with a Ruminococcaceae enterotype (R-type). The Prevotella (P-type) individuals appeared in between the B- and R-type. The differences in stool energy density between enterotypes were not explained by differences in habitual diet, intake of dietary fibre or faecal bacterial cell counts. However, the R-type individuals showed higher urinary and faecal levels of microbial-derived proteolytic metabolites compared to the B-type, suggesting increased colonic proteolysis in the R-type individuals. This could imply a less effective colonic energy extraction in the R-type individuals compared to the B-type individuals. Notably, the R-type had significantly lower body weight compared to the B-type.

Conclusions

Our findings suggest that gut microbial energy harvest is diversified among individuals by intestinal transit time and associated gut microbiome ecosystem variations. A better understanding of these associations could support the development of personalised nutrition and improved weight-loss strategies.
Multivariate moment-matching for model order reduction of quadratic-bilinear systems using error bounds
Authors: Khattak Muhammad Altaf , Ahmad Mian Ilyas , Feng Lihong , Benner Peter
Published: December 2022

We propose an adaptive moment-matching framework for model order reduction of quadratic-bilinear systems. In this framework, an important issue is the selection of those shift frequencies where moment-matching is to be achieved. So far, the choice often has been random or linked to the linear part of the nonlinear system. In this paper, we extend the use of an existing a posteriori error bound for general linear time invariant systems to quadratic-bilinear systems and develop a greedy-type framework to select a good choice of interpolation points for the construction of the projection matrices. The results are compared with standard quadratic-bilinear projection methods and we observe that the approximations obtained by the proposed method yield high accuracy.
Japanese version of the Brief Sense of Community Scale: construct validity and reliability
Authors: Yu Kyung-Ran , Asai Keigo , Hiraizumi Taku , Wakashima Koubun
Published: December 2022

Background

The Brief Sense of Community Scale is a widely accepted eight-item scale that measures the four dimensions of sense of community; however, the factor structure of the Japanese version of this scale has never been confirmed. In this study, we demonstrated the reliability and validity of the Japanese version of the Brief Sense of Community Scale.

Methods

After completing the back translation of the scale, a sample of 993 Japanese individuals completed the Japanese version of the Brief Sense of Community Scale.

Results

The results indicate that the Japanese version of the Brief Sense of Community Scale is comparable to the original scale and demonstrated adequate goodness-of-fit for both the four-factor and second-order models, which demonstrates its validity. Nonetheless, it remains necessary to consider possible cross-national cultural concerns when utilizing the scale.

Conclusions

The Japanese version of the Brief Sense of Community Scale will contribute toward the creation of a community in which all members feel comfortable.
Improving L2 learners’ IELTS task 2 writing: the role of model essays and noticing hypothesis
Authors: Nguyen Long Quoc , Le Ha Van
Published: December 2022

Achieving a sufficient IELTS band score for academic purposes has been a major goal of many L2 learners around the world, especially those in Asia. However, IELTS writing scores were consistently reported to be the lowest when compared to the scores in speaking, reading, and listening. Despite a growing body of research in IELTS writing, little focused on the role of model essays and noticing hypotheses. The present study aimed to fill in this gap by examining whether or not the implementation of both noticing hypothesis and model essays had a discernible influence on learners’ IELTS task 2 writing. To reach this goal, a quasi-experimental design including a pretest and a posttest was conducted with the voluntary participation of 52 undergraduates. These participants were divided into two groups: control group (CG,n= 25), learning in the conventional method (peer feedback and teacher feedback), and experimental group (EG,n= 27), using the noticing-model essays method. Following this, semi-structured interviews were performed to gain insights into the quantitative data. The results from this mixed-methods approach showed that there were significant gains in the overall performance and in the lexical resources subscale in the EG while no considerable changes were observed in the CG. Additionally, the other subscales (task response, grammatical range and accuracy, and cohesion-coherence) did not witness any significant differences between the two groups. Several pedagogical implications and recommendations for future research, especially in the Asian context, were also discussed.
The 50 most cited studies on posterior tibial slope in joint preserving knee surgery
Authors: Vieider Romed P. , Berthold Daniel P. , Runer Armin , Winkler Philipp W. , Schulz Phillip , Rupp Marco-Christopher , Siebenlist Sebastian , Muench Lukas N.
Published: December 2022

Purpose

To determine the 50 most cited studies on posterior tibial slope (PTS) in joint preserving knee surgery and assess their level of evidence, objective study quality scores as well as to examine whether the study quality correlated with the citation count and citation density in the top 50 list.

Methods

A literature search on Web of Science was performed to determine the 50 most cited studies on the topic of PTS in joint preserving knee surgery between 1990 and 2022. The studies were evaluated for their bibliographic parameters, level of evidence rating (LOE), citation counts, the Modified Coleman Methodological Score (MCMS), the Methodological Index for Non-Randomized Studies (MINORS), and the Radiologic Methodology and Quality Scale (MQCSRE).

Results

Of the top 50 list, 16 studies were published in theAmerican Journal of Sports Medicine. A total of 23studies were produced in the United States (46%). Of 10 different study types, case control studies (n = 16, 32%) and cadaveric studies (n = 10, 20%) were most common. 15 studies (30%) were purely radiological studies. 6 studies were level II (12%), 23 level III (46%), 15 level IV (30%), and 6 level V studies (12%), respectively. The number of citations ranged from 42 to 447 (mean 105.6 ± 79.2 citations) and showed a mean citation density of 10.3 ± 5.2, composed of the decades 1994 – 2000 (8.3 ± 4.1), 2001 – 2010 (11.1 ± 5.9), 2011 – 2019 (10.1 ± 5.1). Mean quality scores were 55.9 ± 13.0 for MCMS (n= 18), 14.5 ± 3.2 for MINORS (n = 18) and 18.1 ± 3.7 for MQCSRE (n = 20), respectively. High citation counts did not correlate with higher study quality scores (p > 0.05). Radiological studies were not significantly cited more often than non-radiological studies (mean 116.9 ± 88.3 vs. 100.8 ± 75.8 citations;p > 0.05).

Conclusion

In joint preserving knee surgery, the 50 most cited studies on PTS did not represent a ranking of the highest methodological quality scores. Citation counts and citation density over the past three decades did not significantly differ, even though the number of articles in the presented list multiplied over the same period. This list can serve as a reference tool for orthopedic surgeons aiming to review PTS literature.
Investigating the feasibility and acceptability of using Instagram to engage post-graduate students in a mass communication social media-based health intervention, #WeeStepsToHealth
Authors: O’Kane Niamh , McKinley Michelle C. , Gough Aisling , Hunter Ruth F.
Published: December 2022

Background

Instagram’s popularity among young adults continues to rise, and previous work has identified diffusion of unhealthy messages and misinformation throughout the platform. However, we know little about how to use Instagram to promote health messages. This study aims to assess the feasibility and acceptability of using Instagram to engage post-graduate students in a mass communication social media (SM)-based health intervention.

Methods

A 4-week intervention targeting post-graduate students with physical activity (PA), nutrition, and general wellbeing messages was conducted via Instagram. Feasibility and acceptability were assessed using SM metrics (likes, comments, and shares), pre- and post-intervention online surveys (knowledge, attitude, and behavioural outcomes), and a focus group conducted with a sample of individuals in the target population (to assess intervention recall, feedback on message framing, and acceptability of Instagram).

Results

The two independent samples captured by online surveys (pre-intervention, n = 43, post-intervention, n = 41, representing 12.3% and 11.7% of Instagram followers, respectively) were predominantly female (88.4%, 80.5%) aged 18–34 (95.4%, 95.1%). Respondents in the second survey reported higher weekly PA levels (+ 13.7%) and more frequent nutritional behaviours including consumption of five or more fruits and vegetables (+ 23.3%) and looking at nutritional labels (+ 10.3%). However, respondents in the second survey also reported less frequent meal preparation (− 18.0%) and a small increase in fast food consumption (+ 2.8% consuming fast food 3–4 days a week). A total of 247 ‘likes’ were collected from 28 Instagram posts (mean 8.8 likes per post). Humorous posts achieved a moderately higher level of engagement than non-humorous posts (median 10 and 8 likes, respectively). Focus group participants liked the campaign content and trusted the information source.

Conclusions

Findings indicate that Instagram could be a feasible and acceptable platform for engaging post-graduate students in a SM-based mass communication health intervention, and that humour may have the potential to encourage further engagement.
Transcranial Doppler assessment of patients with cerebral small vessel disease
Authors: Tawfik Mohamed M. , Ebrahim Alaa , Hamed Salma , Haroun Mahmoud
Published: December 2022

Background

Cerebral small vessel disease (SVD) is associated with acute events such as lacunar and hemorrhagic strokes, or chronic events such as cognitive deficit in the form of subcortical dementia, mood deficit in the form of late onset depression, sphincteric affection, and gait apraxia. Under conditions of moderate blood flow deficit, the inability of sclerotic vessels to dilate due to impairment of the cerebral autoregulation, renders the periventricular white matter seriously ischemic. Therefore, it is important to detect the implications of cerebral large artery disease on the severity of SVD, and the ability of transcranial duplex (TCD) to evaluate it in people at risk.

Methods

Fifty lacunar stroke patients were recruited, and evaluated using MRI brain to assess SVD score, carotid duplex and TCD to assess extracranial and intracranial stenoses, respectively.

Results

Both intracranial and extracranial stenoses showed significant relation to the severity of cerebral SVD. Moreover, there were significant relation between intracranial stenosis and presence of lacuna and EPVS.

Conclusion

Cerebral large artery disease contributes to the pathogenesis and severity of cerebral SVD. Therefore, TCD may be a useful tool for the prediction of occurrence of cerebral SVD in high-risk individuals, especially hypertensives.
Navigating the Evolving Treatment Landscape of Diffuse Large B-Cell Lymphoma
Authors: Nastoupil Loretta J. , Bartlett Nancy L.
Published: December 2022

Diffuse large B-cell lymphoma, the most common subtype of non-Hodgkin lymphoma, comprises a heterogenous group of morphologically, genetically, and clinically distinct diseases. Several recent advances have affected the treatment landscape, which had been mostly stagnant for the past few decades. We will review the practice-changing studies in frontline (POLARIX), early relapse (ZUMA-7 and TRANSFORM), and multiple recurrent (ZUMA-1, JULIET, TRANSCEND, L-MIND, and LOTIS-2) stages and discuss how the treatment landscape may evolve with the emergence of bispecific antibodies.
Achilles Tendon Injuries Requiring Surgical Treatment in the Pediatric and Adolescent Population: A Case Series
Authors: Chen Daniel L. , Beran Matthew C. , Duncan Molly , Young Julie A. , Napolitano Jonathan T. , MacDonald James
Published: December 2022

Pediatric Achilles tendon injuries requiring surgical treatment are considered rare and have not been well described. A retrospective chart review was conducted from 2010 to 2020 to identify cases of acute Achilles tendon rupture or laceration that required surgical repair in individuals 19 years or younger. A total of 24 individuals with acute Achilles tendon ruptures (n= 8) and lacerations (n= 16) were identified. All spontaneous ruptures occurred in skeletally mature individuals during sports. One subject was on minocycline at the time of injury, while two had a body mass index (BMI) ≥ 99% for age. Another had a history of clubfoot surgery on the injured side. Patients with lacerations were younger (9.9 ± 3.3 vs 16.3 ± 1.6 years) and had lower BMI (17.3 ± 3.8 vs. 28.0 ± 9.4) than those with spontaneous ruptures. The majority of cases had good outcomes with no postoperative complications.
Primary Periphyseal Stress Injuries of the Fingers in Adolescent Climbers: A Critical Review
Authors: Jones Gareth , Johnson Rowena , Schöffl Volker , Schöffl Isabelle , Lutter Chris , Johnson Mark I. , Halsey Tim
Published: December 2022

The worldwide rise in popularity of climbing and development of climbing as a competitive sport is reflected by its debut at the 2021 Summer Olympic Games in Tokyo. Digital primary periphyseal stress injuries in adolescent climbers may pose a significant risk to long-term skeletal health. The aim of this article is to critically review research on the diagnosis and management of primary periphyseal stress injuries of the fingers in adolescent climbers. We adopted a systematic approach to searching for relevant literature. Articles were identified after searches of the following electronic databases: Discover, Academic Search Complete, PubMed, Embase, SPORTDiscus, and ScienceDirect. Conclusive evidence suggests digital primary periphyseal stress injuries are a consequence of repetitive microtrauma. Pain reported by adolescent climbers on the dorsal aspect of the proximal interphalangeal joint should be investigated promptly to avoid serious negative consequences. Clinicians should be aware of the efficacy of imaging techniques to inform a clinical diagnosis. A conservative management approach is preferred but in rare cases surgical intervention may be necessary. A diagnostic and therapeutic algorithm for digital primary periphyseal stress injuries is presented.
Neural Drive Impairment in Chronic Kidney Disease Patients Is Associated with Neuromuscular Fatigability and Fatigue
Authors: CHATRENET ANTOINE , PICCOLI GIORGINA , ANTHIERENS AGATHE , TORREGGIANI MASSIMO , AUDEBRAND JEAN MICHEL , MOREL BAPTISTE , BEAUNE BRUNO , DURAND SYLVAIN
Published: December 2022

Introduction

Chronic kidney disease (CKD) patients have a high degree of fatigue relating to neuromuscular symptoms. There is a lack of evidence regarding the etiology of neuromuscular fatigability in elderly CKD patients.

Methods

Inclusion criteria are as follows: age ≥60 yr, glomerular filtration rate (GFR) <45 mL·min−1 per 1.73 m2 in CKD patients, and GFR >60 mL·min−1·1.73 m−2 in controls. The fatigability protocol consisted in a submaximal handgrip task at 40% peak force. Fatigue was assessed using the Multidimensional Fatigue Inventory–20 items (MFI-20) and the Functional Assessment of Chronic Illness Therapy–Fatigue questionnaires. Peak rate of force development (RFDpeak, normalized: NRFDpeak) and rate of EMG rise (RER) were measured during explosive contractions; peak force and mean surface EMG were measured during maximum voluntary contractions. Multilevel models tested neuromuscular parameters adjusted for clinical and Multidimensional Fatigue Inventory–20 items subscales. Neuromuscular fatigability contribution to fatigue description was tested using model comparison.

Results

The study included 102 participants; 45 CKD patients and 57 controls. CKD mainly affected the mental and the reduced motivation subscales of fatigue. CKD was associated with greater neuromuscular fatigability assessed using NRFDpeak (group–time interaction, −16.7 % MVF·s−1, P = 0.024), which increased with fatigue severity (P = 0.018) and with a higher rate of decrement in RER compared with controls (RER at 50 ms: β = −121.2 μV·s−1, P = 0.016, and β = −48.5 μV·s−1, P = 0.196, respectively). Furthermore, these patients show an association between the reduced motivation subscale and the RER (e.g., 30 ms: β = −59.8% EMGpeak·s−1, P < 0.001). Only peak force fatigability contributed to fatigue variance, whereas RFDpeak did not.

Conclusions

In CKD patients, the neuromuscular fatigability assessed using RFDpeak is related to an impairment in motor-unit recruitment or discharge rates, whereas only peak force fatigability was related to fatigue. This suggests that targeting exercise interventions might lessen fatigue and improve quality of life in CKD patients.
Circadian stabilization loop: the regulatory hub and therapeutic target promoting circadian resilience and physiological health
Authors: Kim Eunju , Yoo Seung-Hee , Chen Zheng
Published: December 2022

The circadian clock is a fundamental biological mechanism that orchestrates essential cellular and physiological processes to optimize fitness and health. The basic functional unit is the cell-autonomous oscillator, consisting of intersecting negative feedback loops. Whereas the core loop is primarily responsible for rhythm generation, auxiliary loops, most notably the secondary or stabilization loop, play pivotal roles to confer temporal precision and molecular robustness. The stabilization loop contains opposing nuclear receptor subfamilies REV-ERBs and retinoic acid receptor-related orphan receptors (RORs), competing to modulate rhythmic expression of the basic helix-loop-helix ARNT like 1 (Bmal1) genes in the core loop as well as other clock-controlled genes. Therefore, REV-ERBs and RORs are strategically located to interface the oscillator and the global transcriptomic network, promoting cellular homeostasis and physiological fitness throughout lifespan. Disruption of REV-ERB and ROR functions has been linked with diseases and aging, and pharmacological manipulation of these factors has shown promise in various mouse disease models. Nobiletin is a natural compound that directly binds to and activates RORα/γ, modulating circadian rhythms, and shows robust in vivo efficacies to combat clock-associated pathophysiologies and age-related decline. Results from several studies demonstrate an inverse relation between nobiletin efficacy and clock functional state, where nobiletin elicits little effect in young and healthy mice with growing efficacy as the clock is perturbed by environmental and genetic challenges. This mode of action is consistent with the function of the stabilization loop to promote circadian and physiological resilience. Future studies should further investigate the function and mechanism of REV-ERBs and RORs, and test strategies targeting these factors against disease and aging.
DETECTION OF CREDIT CARD FRAUDS WITH MACHINE LEARNING SOLUTIONS: AN EXPERIMENTAL APPROACH
Authors: Mabani Courage , Tuskov Andrey A. , Shchanina Elizaveta V.
Published: December 2022

Purpose – propose an experimental way to create ML solutions to the problem of detecting credit card fraud.

Method or methodology of the work: the article uses machine learning (ML) and data mining methods

Results: the paper showed that machine learning (ML) and data mining techniques are effective in improving fraud detection accuracy. The study proposes an experimental way to create ML solutions to the problem aimed at minimizing financial losses by monitoring the client’s behavior when using credit cards. The model is tested on a publicly available dataset available to the research community in terms of detection accuracy.

The sphere of application of the results: in practice, it is advisable to use the results when planning effective strategies for detecting fraud in credit cards.
Learning Fables: Third Grade Literary Reading Lesson
Authors: Voskoboynikova E. , Struchaeva T.
Published: December 2022

The article presents a possible version of the methodology for studying fables as a genre of literary work in the third grade. Such teaching methods and techniques are disclosed as the analysis of literary models, "SMS messages", work with an explanatory dictionary, comparison of several literary texts. The significance of the formation of expressive reading skills in third-graders on the basis of their joint activities in pairs is discussed. Particular attention is paid to the description of individual studies of students, conducted on the basis of works of art.
The development of the personality of a younger student is a priority goal of modern primary education (Part 2)
Authors: Vinogradova Natalya
Published: December 2022

The article deals with the problem of the development of the personality of a younger schoolchild as a member of Russian society, a citizen of the Russian Federation, as well as a subject of a new for him, socially important educational and cognitive activity. The content of the process of education in elementary school, its methods, techniques and forms of organization are characterized. Examples of the integration of educational and upbringing tasks in the classroom and in extracurricular activities of schoolchildren are given.
O trzęsieniach ziemi w średniowieczu i ich badaniu. Wokół pracy Konrada Schellbacha Erdbeben in der Geschichtsschreibung des Frühund Hochmittelalters. Ursprung, Verständnis und Anwendung einer spezifisch mittelalterlichen Traditionsbildung
Authors: Krawiec Adam
Published: December 2022

Głównym tematem artykułu jest monografia Konrada Schellbacha poświęcona sposobowi konceptualizacji fenomenu trzęsienia ziemi w dziejopisarstwie łacińskim od końca VIII do połowy XIII w. Została ona omówiona na szerszym tle problematyki badań nad dawnymi zjawiskami sejsmicznymi. Krytycznej analizie poddane zostały założenia pracy oraz efekty ich realizacji, ze szczególnym uwzględnieniem doboru analizowanych treści, a także możliwości źródłowej weryfikacji tez, stawianych w pracy przez Autora.
Produkcja ksiąg muzycznych w skryptorium lubiąskim do połowy XIV w.
Authors: Chachulska Irina
Published: December 2022

Badania pisma muzycznego ksiąg cysterskich na Śląsku, podjęte z uwzględnieniem osiągnięć badaczy z zakresu paleografii i iluminacji książkowej, pozwoliły na identyfikację kolejnych woluminów lubiąskiego pochodzenia, poszerzając tym samym grupę znanych źródeł sporządzonych w tym skryptorium. Artykuł przedstawia aktualną listę źródeł muzycznych (20 jednostek) powstałych w Lubiążu od powstania opactwa w trzeciej ćwierci XII w. do połowy XIV stulecia.
Księgi gromadzkie we wsiach Ordynacji Zamojskiej oraz na terytoriach sąsiednich w drugiej połowie XVII i w XVIII w.
Authors: Łosowski Janusz
Published: December 2022

W artykule przedstawiono dyskusję dotyczącą genezy, istoty i funkcji ksiąg gromadzkich w okresie staropolskim, którą Stanisław Grodziski i Ludwik Łysiak toczyli w latach 60. ubiegłego stulecia. W dalszej części tekstu dokonano charakterystyki organizacji Ordynacji Zamojskiej i jej sądownictwa, a także opisano nieznane badaczom przypadki używania ksiąg gromadzkich w należących do niej dobrach wiejskich. Przeanalizowano również nieliczne informacje o tego rodzaju księgach funkcjonujących w ziemi lubelskiej. Dokonano też próby wyjaśnienia powodów niewykorzystywania ksiąg gromadzkich w ziemi chełmskiej (poza terenem Ordynacji). Nieliczne wzmianki o istnieniu ksiąg gromadzkich na tych terenach stanowią dowód słuszności tezy L. Łysiaka o ich rzadkim występowaniu w Rzeczypospolitej poza południową Małopolską i zachodnią częścią województwa ruskiego.
Género y estructura capitalista-patriarcal en la escena latinoamericana.
Authors: Proaño Gomez Lola
Published: December 2022

Este ensayo reflexiona sobre las últimas producciones escénicas feministas de algunos países latinoamericanos y propone que, junto al feminismo popular, es un espacio ideológico que plantea reivindicaciones por la justicia de género centrándose en los conflictos específicos contemporáneos. El ensayo analiza la escena, como metáfora dramática y visual y su sentido en la lucha de los derechos de género (Esquinas en el cielo y Mecánicas); el desplazamiento del sujeto masculino de ciertos espacios y la ocupación de los mismos por sujetos no masculinos como posible causa de la violencia de género (Ya vas a ver y Femicidio es Genocidio) y finalmente, la lucha feminista en los colectivos artivistas (ARDA, Lastesis y la Corporación Colombiana de Teatro) con la característica de una nueva y poderosa presencia del cuerpo plural y colectivo en las acciones, el surgimiento de espacios de aparición y de afectividad que afirma y exhibe la lucha feminista en los espacios del poder. Esta escena dialoga con la contextualidad histórico-política contemporánea y las asociaciones simbólico-culturales y ofrece una mirada nada ingenua con nuevas herramientas teatrales y una creciente sutileza ideológica.
Liquidity Windfalls and Reallocation: Evidence from Farming and Fracking
Authors: Thakor Richard T.
Published: December 2022

Financing frictions may create a misallocation of assets in a market, thus depressing output, productivity, and asset values. This paper empirically explores how liquidity shocks generate a reallocation that diminishes this misallocation. Using a unique data set of agricultural outcomes, I explore how farmers respond to a relaxation of financial constraints through a liquidity shock unrelated to farming fundamentals, namely exogenous cash inflows caused by an expansion of hydraulic fracturing (fracking) leases. Farmers experiencing positive cash flow shocks increase their land purchases, which results in a reallocation effect. Examining purchases across areas, I find that farmers in high-productivity areas who receive cash flow shocks buy farmland in low-productivity areas, but farmers in low-productivity areas receiving positive cash flow shocks do not. Moreover, farmers increase their purchases of vacant (undeveloped) land. Average output, productivity, equipment investment, and profits all increase significantly following these positive cash flow shocks. Farmland prices also rise significantly, consistent with a cash-in-the-market pricing effect. These effects are consistent with an efficient reallocation of land toward more productive users.

This paper was accepted by Tyler Shumway, finance.

Funding: This work was supported by the Kritzman and Gorman Research Fund Grant.

Supplemental Material: The online appendix is available at https://doi.org/10.1287/mnsc.2022.4602 .
Evaluating the Occurrence and Relative Abundance of Mosquitoes in Rainwater Harvesting Systems
Authors: Gee Kathy DeBusk , Dobyns Kaitlyn , Gage Kyrsten , Woodward Mitch , Hunt William , Kennedy Shawn , Lehr David
Published: December 2022

Highlights

Rainwater harvesting systems can harbor mosquitoes and their larvae.

Approximately half of sampled systems were found to contain mosquito larvae.

Mosquitoes were more abundant in systems with unscreened openings and multiple inlet filters.

Frequent maintenance and eliminating unscreened openings minimize mosquito presence.

Abstract. Mosquitoes are associated with the spread of diseases such as the Zika and West Nile viruses. Government and health officials recommend the elimination of standing water to prevent the breeding of mosquitoes that transmit these viruses. Previous research has shown that rainwater harvesting (RWH) systems in high-rainfall regions tend to be underutilized, thereby creating a source of standing water that could potentially harbor mosquitoes and their larvae. As RWH is an important tool for conserving potable water and mitigating stormwater runoff, it is imperative to determine if these systems are contributing to the proliferation of mosquitoes and, if they are, to identify measures to prevent this. The prevalence and relative abundance of mosquitoes were investigated in 64 RWH cisterns throughout Virginia and North Carolina. Mosquito larvae captured during sampling were identified morphologically to genus and species. Of the 64 systems sampled, 47% contained mosquitoes; the predominant species found was Aedes albopictus, a potential carrier of Eastern Equine Encephalitis, LaCrosse Encephalitis, West Nile virus, and Zika virus. Systems with multiple inlet filters, unscreened storage tank openings, and/or heavy foliage in the immediate vicinity were most likely to contain mosquito larvae. Study results indicate that frequent maintenance, the elimination of unscreened tank openings, and the eradication of sources of standing water in the area surrounding a system greatly reduce the likelihood of mosquitoes proliferating in rainwater harvesting systems. Keywords: Container breeding, Mosquito, Mosquito larvae, Rainwater harvesting.
La violencia institucional en las sanciones disciplinarias a reclusas
Authors: Alonso Merino Alicia
Published: December 2022

El estudio en profundidad de las sanciones disciplinarias, a través de entrevistas realizadas a reclusas,  revela la existencia de una serie de violencias institucionales que se producen o que son causas del régimen de control. Para las mujeres y disidencias privadas de libertad, la prisión además es un continuum de las violencias de género vividas extramuros. De tal manera que algunas manifestaciones de la violencia institucional se intersecan con violencias propias de otros sistemas de dominación como en el caso del patriarcado, reforzando el rol de sumisión que para ellas representa la prisión.  
Palabras Claves: Cárceles, violencia institucional, sanciones disciplinarias, presas, violencia de género
Marina Graziosi, In Memoriam
Authors: Rivera Beiras Iñaki
Published: December 2022

Debo empezar por reconocer que no me es nada fácil escribir este texto in memoriam de Marina Graziosi. El recuerdo de esta extraordinaria mujer, tan jovial como fina y generosa en la relación que me deparó, hacen muy difícil tener una “distancia” que permita comentar algo de su vida y sus obras. No obstante ello, y con la firme voluntad de difundir ambas dimensiones de Marina, me acerco a los recuerdos y a sus escritos, esperando que este texto contribuya al necesario conocimiento de la querida amiga, profesora comprometida y autora italiana
Gerlinda Smaus - In Memoriam
Authors: Giannoulis Christina
Published: December 2022

Gerlinda Šmausová (13/12/1940 – 01/06/2022). Fue sobre todo una científica excepcional: profesora de sociología, crítica del sistema de justicia penal, y defensora de la criminología crítica, feminista.
Mask configurable readout circuit architecture for an ultra-high-resolution CMOS image sensor: publisher’s note
Authors: Nie Kaiming , Liu Jingheng , Wang Dejian , Xu Jiangtao , Yang Zhengxu , Gao Zhiyuan
Published: December 2022

This publisher’s note reports a correction in Appl. Opt. 61, 2565 (2022)APOPAI0003-693510.1364/AO.453904.
Logistic splicing correction for VNIR–SWIR reflectance imaging spectroscopy
Authors: Grillini Federico , Thomas Jean-Baptiste , George Sony
Published: December 2022

In the field of spectroscopy, a splicing correction is a process by which two spectra captured with different sensors in adjacent or overlapping electromagnetic spectrum ranges are smoothly connected. In our study, we extend this concept to the case of reflectance imaging spectroscopy in the visible–near-infrared (VNIR) and short-wave infrared (SWIR), accounting for additional sources of noise that arise at the pixel level. The proposed approach exploits the adaptive fitting of a logistic function to compute correcting coefficients that harmonize the two spectral sets. This short Letter addresses usage conditions and compares results against the existing state of the art.
Factors associated with stunting among children 0 to 59 months of age in Angola: A cross-sectional study using the 2015–2016 Demographic and Health Survey
Authors: Correa Paulo Renato
Published: December 2022

Stunting among children under five years of age is a serious public health problem globally, with life-long consequences to health, well-being, and productivity. Stunted growth has complex and multifactorial causes, reflecting the interaction of a broad range of conditions that determine child health. The Angola 2015–2016 Demographic and Health Survey (DHS) collected nationally representative anthropometry for 6,359 children 0 to 59 months of age in Angola, and ascertained exposure to a wide range of child, parental, socio-economic, and geographic variables. This study used a cross-sectional design to identify exposures associated with stunting among children 0 to 59 months of age in Angola, while considering the multifactorial and multi-level causes of stunting. Main outcome was prevalence of stunting, defined as proportion of children with height-for-age Z-score (HAZ) two or more standard deviations below the median. Prevalence of stunting was associated with individual, household, and area-level exposure variables, including child age and sex, birth order, birthweight, diarrhea, maternal and paternal age and education, source of water, sanitary system, and province. In conclusion, prevalence of stunting in Angola is associated with several factors previously described in the literature. Stunting is associated with exposures at the distal, intermediate, and proximal levels, in line with the framework on the causes of childhood malnutrition. This study identifies opportunities for interventions at multiple levels to decrease prevalence of stunting among children in Angola. Main limitations of this study are the potential for survival bias and residual confounding.