bluuebunny/crossref_metadata_2025 huggingface dataset:
Patients’Perceptions of Having a Good Life One Year after Arthritis Patient Education: A Qualitative Study Nested within a Randomized Controlled Trial
Authors: Grønning Kjersti , Bratås Ola , Steinsbekk Aslak
Published: July 2017

Background: Patients with inflammatory polyarthritis have various degrees of disease-related challenges such as joint pain, stiffness, fatigue, and physical limitations. Despite these challenges, patients strive for a good life using their personal resources, often taught in patient education. The effect of patient education in polyarthritis is well studied; however, long-term studies on what patients perceive as a good life after participating in arthritis patient education are scarce.Purpose: The aim of this study was to explore patients’ perceptions of having a good life one year after attending a nurse-led patient education intervention.Methods: This was a qualitative study nested within a randomized controlled trial (RCT) studying the effect of nurse-led patient education. Fifteen individual semi-structured interviews were conducted among those who attended the nurse-led patient education intervention. The intervention focused on the consequences of living with chronic inflammatory arthritis. The interviews explored how and whether the intervention had made any changes in the informants perceived health, well-being, arthritis, flares, and treatment regimes. The data were analyzed thematically using systematic text condensation.Results: The findings showed that the informants’ perceptions of having a good life were related to a stable disease with few symptoms, effective treatment regimes, discovering new opportunities and perspectives in life, as well as making choices that felt right. Creating a good life was something the informants had acquired knowledge about in the nurse-led patient education intervention, particularly in the part where they had discussed and shared experiences with each other on how they managed their arthritis in different ways and settings.Conclusion: Participating in a nurse-led patient education intervention in arthritis helped the informants to discover new opportunities and perspectives on creating a good life, especially through exchanging experiences with fellow patients.
Ultrastructure of the spermatozoon of Macvicaria obovata (Digenea: Opecoelidae), a parasite of Sparus aurata(Pisces: Teleostei) from the Gulf of Gabès, Mediterranean Sea
Authors: Kacem Hichem , Quilichini Yann , Neifar Lassad , Torres Jordi , Miquel Jordi
Published: July 2017

The ultrastructural organization of the spermatozoon of the digenean
Durettenema guangdongense gen. et sp. nov. (Nematoda: Molineoidea) from Hipposideros larvatus (Horsfield) (Chiroptera: Rhinolophidae) with discussion of the taxonomic status of Macielia rhinolophi Yin, 1980
Authors: Ju Hui-Dong , Li Liang , Zhang Lu-Ping
Published: July 2017

gen. et sp. nov. is described from
Comparison Between the Economic-Statistical Design of Double and Triple Sampling X¯\bar{X} Control Charts
Authors: Iziy Azamsadat , Sadeghpour Gildeh Bahram , Monabbati Ehsan
Published: July 2017

Control charts have been established as major tools for quality control and improvement in industry. Therefore, it is always required to consider an appropriate design of a control chart from an economical point of view before using the chart.
The economic design of a control chart refers to the determination of three optimal control chart parameters: sample size, the sampling interval, and the control limits coefficient.
In this article, the double sampling (DS)

X
¯

{\bar{X}}

control chart is considered for the
economic design using nonlinear mixed integer programming approach. The triple sampling (TS)

X
¯

{\bar{X}}

control charts are developed for economic design based on the results of solving the DS

X
¯

{\bar{X}}

chart design problems.
In this model, we assume that the process must be shut down during the search for the assignable cause.
Multiple sampling

X
¯

{\bar{X}}

charts can be designed for quick detection of a small shift in process.
The results of the comparison between the economic-statistical design of DS and TS

X
¯

{\bar{X}}

control charts show that TS

X
¯

{\bar{X}}

control charts are more efficient in terms of minimizing the average sample size, but its expected average cost takes larger values.
Conceptual roots for innovation and innovativeness of the economy in Poland
Authors: Strahl Danuta , Sobczak Roman
Published: July 2017

The purpose of the article is to provide the evolutionary review and systemization of the basic concepts related to innovation and innovativeness in Polish research on regional economics and development. The emphasis is placed on the types of innovation and innovativeness of the economy and the main conceptual and practical sources for the innovation and innovativeness concept are being discussed within the framework of European regional policy.
Looks can be deceiving: body image dissatisfaction relates to social anxiety through fear of negative evaluation
Authors: Pawijit Yada , Likhitsuwan Watcharaphon , Ludington Jason , Pisitsungkagarn Kullaya
Published: July 2017

Introduction

Emerging adults are particularly vulnerable to body image dissatisfaction and social anxiety. These bring about a host of negative outcomes, including compromised social adjustment and well-being. Fear of negative evaluation has been shown to be a core element of social anxiety, but it is rarely considered in studies of body image and its effects on social anxiety. This study aimed to bridge this gap by examining the role of fear of negative evaluation in the association between body image dissatisfaction and social anxiety.

Methods

A cross-sectional study using 80 Thai undergraduates (mean age of 21 years) was conducted by self-reported (questionnaire) measures. Body image dissatisfaction was measured with the short version of the Body Shape Questionnaire (BSQ-8C), fear of negative evaluation with the Brief Fear of Negative Evaluation Scale, and social anxiety with the Interaction Anxiousness Scale (IAS). Correlation and mediation analyses were conducted to assess how these constructs were related to one another.

Results

The key hypothesis was supported: positive associations were found among body image dissatisfaction, fear of negative evaluation and social anxiety, and the association between body image dissatisfaction and social anxiety was mediated by fear of negative evaluation.

Discussion

Generalizing from the current findings, ideas for possible amelioration of social anxiety are discussed.
In utero virilization secondary to a maternal Krukenberg tumor: case report and review of literature
Authors: Bustamante Carmen , Hoyos-Martínez Alfonso , Pirela Daniela , Díaz Alejandro
Published: July 2017

Background:

Krukenberg tumors are ovarian metastatic adenocarcinomas with a primary origin usually located in the stomach, colon, gallbladder, pancreas, or breast. Occasionally, these tumors produce virilization in the affected individual due to androgen production by luteinization of the tumoral stroma. It is believed that during pregnancy these tumors are more likely to increase androgen production due to the elevated levels of human chorionic gonadotropin (hCG). High maternal androgens can cross the placenta producing virilization of the female fetus.

Case presentation:

A 46,XX newborn female, whose mother was diagnosed with a metastatic ovarian tumor during her second trimester of gestation associated with worsening hirsutism and acne, was found to have ambiguous genitalia at birth. Testosterone levels in both the mother and infant were elevated. Follow-up laboratory tests showed progressive normalization of circulating androgens after delivery.

Conclusions:

Krukenberg tumors are rare and may produce virilization of the mother and the female fetus when present during pregnancy.
Effects of Wearing a Compression Garment During Night Sleep on Recovery From High-Intensity Eccentric-Concentric Quadriceps Muscle Fatigue
Authors: Shimokochi Yohei , Kuwano Satoshi , Yamaguchi Taichi , Abutani Hiroyuki , Shima Norihiro
Published: July 2017

Shimokochi, Y, Kuwano, S, Yamaguchi, T, Abutani, H, and Shima, N. Effects of wearing a compression garment during night sleep on recovery from high-intensity eccentric-concentric quadriceps muscle fatigue. J Strength Cond Res 31(10): 2816–2824, 2017—This study aimed to investigate the effects of wearing a compression garment (CG) during night sleep on muscle fatigue recovery after high-intensity eccentric and concentric knee extensor exercises. Seventeen male college students participated in 2 experimental sessions under CG and non-CG (NCG) wearing conditions. Before night sleep under CG or NCG wearing conditions, the subjects performed a fatiguing protocol consisting of 10 sets of 10 repetitions of maximal isokinetic eccentric and concentric knee extensor contractions, with 30-second rest intervals between the sets. Immediately before and after and 24 hours after the fatiguing protocol, maximum voluntary isometric contraction (MVIC) force for knee extensor muscles was measured; surface electromyographic data from the vastus medialis and rectus femoris were also measured. A 2-way repeated-measure analysis of variance followed by Bonferroni pairwise comparisons were used to analyze the differences in each variable. Paired-sample t-tests were used to analyze the mean differences between the conditions at the same time points for each variable. The MVIC 24 hours after the fatiguing protocol was approximately 10% greater in the CG than in the NCG condition (p = 0.033). Changes in the electromyographic variables over time did not significantly differ between the conditions. Thus, it was concluded that wearing a CG during night sleep may promote localized muscle fatigue recovery but does not influence neurological factors after the fatiguing exercise.
UM GEOPARK NA REGIÃO DE CAÇAPAVA DO SUL (RS, BRASIL): UMA DISCUSSÃO SOBRE VIABILIDADE E ABRANGÊNCIA TERRITORIAL / A GEOPARK IN THE REGION OF CAÇAPAVA DO SUL (RIO GRANDE DO SUL STATE, BRAZIL): A DISCUSSION ON VIABILITY AND TERRITORIAL LIMITS
Authors: De Borba André Weissheimer
Published: July 2017

Este trabalho discute o potencial e os desafios para a implementação e eventual certificação de uma estratégia tipo geopark na região de Caçapava do Sul, situada na chamada ‘metade sul’ gaúcha e na bacia do Alto Camaquã, extremo sul do Brasil. Possuidora de um contexto geológico-geomorfológico de nível internacional, representado pelas unidades pós-orogênicas da Bacia do Camaquã, e de geoformas de singular importância ecológica e beleza cênica, a região ainda não conta com unidades de conservação da natureza, mas já apresenta iniciativas de educação geopatrimonial e possui públicos interessantes para o geoturismo. Discutem-se aqui cinco possíveis abrangências territoriais para um eventual geopark, sendo as mais indicadas aquelas em que Caçapava do Sul compartilhe estratégias com os municípios vizinhos de Santana da Boa Vista e Lavras do Sul.Abstract:This paper discusses the potential and the challenges aiming at the adoption and possible certification of a geopark strategy for the region of Caçapava do Sul, located at the Camaquã river highlands, in the ‘southern half’ of the Rio Grande do Sul State of southernmost Brazil. The region encompasses a geological-geomorphological context of international level, represented by the post-orogenic stratigraphic units of the Camaquã Basin, as well as a relief of singular ecological importance and scenic beauty. Despite this, the region lacks official protected areas. There are, however, some initiatives of geoheritage education and an interesting public for geotourism. Five possible territorial limits for a geopark in that region are herein discussed, the most indicated being those in which Caçapava do Sul shares strategies with the neighboring municipalities of Santana da Boa Vista and Lavras do Sul.Keywords: geoconservation; geotourism; geopark; sustainable development; territorial limits.
FUNGOS PREDADORES DE NEMATOIDES EM AMOSTRAS DE SOLO DO MUNICÍPIO DE ALEGRETE-RS
Authors: Serra Emanoele Figueiredo , Silva Anna Luiza , Ripoll Márcia Kutscher , Tavares Nicolas Conter , Waller Stefanie Bressan , Osório Luiza Da Gama , Faria Renata Osório de , Meireles Mário Carlos Araújo
Published: July 2017

O controle das endoparasitoses representa um grande desafio em vista do desenvolvimento de resistência dos parasitas aos medicamentos anti-helmínticos disponíveis, o que estimula a busca por formas alternativas de controle. Os fungos nematófagos são espécies capazes de utilizar larvas de nematoides como forma de nutrição podendo ser classificados como ovicidas, endoparasitos ou predadores. Fungos predadores são telúricos, saprofíticos e, em condições especiais, produzem armadilhas tridimensionais para capturar os nematoides. Por essa atividade nematofágica, os fungos predadores podem ser utilizados como controladores biológicos de larvas de parasitas no meio ambiente, evitando a ingestão dessas larvas pelos animais e sua posterior infestação. Este trabalho objetivou o isolamento de fungos predadores de nematoides a partir de amostras de solo do município de Alegrete-RS. Para isolar os fungos utilizou-se a técnica de espalhamento do solo sobre ágar-água a 2%, adicionando-se nematoides Panagrellus redivivus como isca para demonstração das estruturas predatórias fúngicas. Mediante aprisionamentos coletou-se o micélio reprodutivo fúngico que foi ressemeado em meio de cultura PDA para purificação das colônias. A identificação dos isolados foi realizada visualizando-se as características morfológicas das colônias, microcultura e exame direto com base em chaves classificatórias. Foram isolados, a partir das amostras de solo, duas espécies de fungos predadores identificados como Fusarium solani e Fusarium xylarioides. Portanto, conclui-se que existem fungos telúricos com atividade nematofágica no município de Alegrete-RS com uso potencial para descontaminação de pastagens.
Mitochondrial genome inheritance and replacement in the human germline
Authors: Wolf Don P , Hayama Tomonari , Mitalipov Shoukhrat
Published: July 2017

Mitochondria, the ubiquitous power packs in nearly every eukaryotic cell, contain their own DNA, known as mtDNA, which is inherited exclusively from the mother. The number of mitochondrial genomes varies depending on the cell's energy needs. The mature oocyte contains the highest number of mitochondria of any cell type, although there is little if any mtDNA replication after fertilization until the embryo implants. This has potential repercussions for mitochondrial replacement therapy (MRT; see description of currently employed methods below) used to prevent the transmission of mtDNA‐based disorders. If only a few mitochondria with defective mtDNA are left in the embryo and undergo extensive replication, it might therefore thwart the purpose of MRT. In order to improve the safety and efficacy of this experimental therapy, we need a better understanding of how and which mtDNA is tagged for replication versus transcription after fertilization of the oocyte.
Connected Gene Communities Underlie Transcriptional Changes in Cornelia de Lange Syndrome
Authors: Boudaoud Imène , Fournier Éric , Baguette Audrey , Vallée Maxime , Lamaze Fabien C , Droit Arnaud , Bilodeau Steve
Published: July 2017

Cornelia de Lange syndrome (CdLS) is a complex multisystem developmental disorder caused by mutations in cohesin subunits and regulators. While its precise molecular mechanisms are not well defined, they point toward a global deregulation of the transcriptional gene expression program. Cohesin is associated with the boundaries of chromosome domains and with enhancer and promoter regions connecting the three-dimensional genome organization with transcriptional regulation. Here, we show that connected gene communities, structures emerging from the interactions of noncoding regulatory elements and genes in the three-dimensional chromosomal space, provide a molecular explanation for the pathoetiology of CdLS associated with mutations in the cohesin-loading factor NIPBL and the cohesin subunit SMC1A. NIPBL and cohesin are important constituents of connected gene communities that are centrally positioned at noncoding regulatory elements. Accordingly, genes deregulated in CdLS are positioned within reach of NIPBL- and cohesin-occupied regions through promoter–promoter interactions. Our findings suggest a dynamic model where NIPBL loads cohesin to connect genes in communities, offering an explanation for the gene expression deregulation in the CdLS.
Predicting Risk of Serious Bacterial Infections in Febrile Children in the Emergency Department
Authors: Irwin Adam D. , Grant Alison , Williams Rhian , Kolamunnage-Dona Ruwanthi , Drew Richard J. , Paulus Stephane , Jeffers Graham , Williams Kim , Breen Rachel , Preston Jennifer , Appelbe Duncan , Chesters Christine , Newland Paul , Marzouk Omnia , McNamara Paul S. , Diggle Peter J. , Carrol Enitan D.
Published: July 2017

BACKGROUND:

Improving the diagnosis of serious bacterial infections (SBIs) in the children’s emergency department is a clinical priority. Early recognition reduces morbidity and mortality, and supporting clinicians in ruling out SBIs may limit unnecessary admissions and antibiotic use.

METHODS:

A prospective, diagnostic accuracy study of clinical and biomarker variables in the diagnosis of SBIs (pneumonia or other SBI) in febrile children <16 years old. A diagnostic model was derived by using multinomial logistic regression and internally validated. External validation of a published model was undertaken, followed by model updating and extension by the inclusion of procalcitonin and resistin.

RESULTS:

There were 1101 children studied, of whom 264 had an SBI. A diagnostic model discriminated well between pneumonia and no SBI (concordance statistic 0.84, 95% confidence interval 0.78–0.90) and between other SBIs and no SBI (0.77, 95% confidence interval 0.71–0.83) on internal validation. A published model discriminated well on external validation. Model updating yielded good calibration with good performance at both high-risk (positive likelihood ratios: 6.46 and 5.13 for pneumonia and other SBI, respectively) and low-risk (negative likelihood ratios: 0.16 and 0.13, respectively) thresholds. Extending the model with procalcitonin and resistin yielded improvements in discrimination.

CONCLUSIONS:

Diagnostic models discriminated well between pneumonia, other SBIs, and no SBI in febrile children in the emergency department. Improvements in the classification of nonevents have the potential to reduce unnecessary hospital admissions and improve antibiotic prescribing. The benefits of this improved risk prediction should be further evaluated in robust impact studies.
LAS CELDAS SOLARES COMO ALTERNATIVA PEDAGÓGICA EN LA ENSEN˜ ANZA DE LA ELECTRICIDAD
Authors: Calderón Clara , Aguirre John
Published: July 2017

En este trabajo se usan las celdas solares para enseñar a los estudiantes de educación media los conceptos básicos de electricidad y la importancia del uso de fuentes de energía renovable y no contaminante para generar electricidad. Para lograr estos objetivos se diseñó y desarrolló un programa de actividades pedagógicas en el cual se usaron diferentes metodologías y se llevaron a cabo varias actividades dentro del proceso de enseñanza-aprendizaje. Las actividades desarrolladas permitieron enseñar a las nuevas generaciones las ventajas de usar la energía solar para obtener energía eléctrica, con respecto al uso de fuentes de energía no renovables que principalmente se usan en la actualidad. Mediante el funcionamiento de un dispositivo de alta tecnología como la celda solar, se enseñaron los conceptos de corriente eléctrica, voltaje, resistencia y potencia eléctrica. La enseñanza de los conceptos de electricidad de esta forma novedosa constituye un ejemplo de innovación en el proceso de enseñanza-aprendizaje en el nivel de educación secundaria, que involucra el fomento del uso de energías provenientes de fuentes renovables en la enseñanza tradicional. El aprendizaje y la motivación de los estudiantes se evidenciaron en el desarrollo de proyectos escolares en los cuales utilizaron las celdas solares.
Identificación de especies del género Colletotrichum asociadas a la antracnosis en papaya (Carica papaya L.) en Costa Rica1
Authors: Molina-Chaves Anthony , Gómez-Alpízar Luis , Umaña-Rojas Gerardina
Published: July 2017

La antracnosis, causada por Colletotrichum spp., es una de la enfermedades poscosecha más importantes en papaya. En este estudio, frutas de papaya, híbrido Pococí, recolectados en plantaciones ubicadas en el cantón de Guácimo, provincia de Limón, presentaron 7 síntomas de antracnosis, luego de un período de almacenamiento. De cada síntoma se obtuvieron aislados de Colletotrichum en medio de cultivo PDA (papa-dextrosa-agar). Los aislamientos se clasificaron en 3 grupos según la similitud de los síntomas y la morfología de la colonia. El análisis de la secuencia de la región espaciadora interna transcrita (ITS) del ADN ribosomal reveló que los aislamientos pertenecieron a 3 especies del género Colletotrichum: C. gloeosporioides sensu lato, C. magnum y C. capsici (C. truncatum). La identificación de las especies fue confirmada con imprimadores taxón específico para C. gloeosporioides e imprimadores especie-específicos para C. magnum. Las 3 especies identificadas mostraron ser patogénicas sobre frutas de papaya. Las especies C. magnum y C. capsici (C. truncatum) se registran por primera vez en Costa Rica, como agentes causales de la antracnosis en papaya.
Da’i Muda Pilihan (DMP) ANTV dalam Perspektif Dakwah
Authors: Fatmawati Fatmawati
Published: July 2017

This paper attempts to unravel the involvement of media in orbit would be preachers and da'iah as a television program. The position of television as a medium to be very important in clarifying the boundaries of da'iah professionalism because a preacher or items related to the assessment standards applied by the media as an organizer of the contest. In addition, this paper also presents the phenomenon of young preachers that the selection program is a form of positive cooperation between the Islamic syi'ar the media so that the message of Islam can exist in the development of information and communication technology is rapidly increasing.
Pemikiran Muthahhari tentang Manusia Masa Depan sebagai Subyek Dakwah
Authors: Sanusi Irfan
Published: July 2017

This paper departed from Muthahhari’s statement that human nature in Islam is paradoxical creatures. In itself there are good qualities and have a tendency to go towards the truths and sacred entities, and the nature of evil as well. All of this is the potential of the human being and should establish itself to become a more perfect self. In view Muthahhari, man as the vicegerent of Allah on earth and as the preaching subjects in which have the nature of God confess, free reliable. Humans as subjects of da’wah initiated the tendency towards good and evil, with their capacity that is not limited, having a whole and instinctive dignity, human driving motivation in many ways is not only material but is transcendent (divine) that finally can freely make use of the grace and gifts bestowed him that will shape the future humans as subjects propaganda bright, awakened, has theistic and spiritual freedom and not experiencing alienation of the self, the world and God.
Minat dan Bakat Mahasiswa Dakwah Pada Kegiatan Khithabah
Authors: Junaedi Jujun
Published: July 2017

Khithabah as part of sermons, including one method of propagation in the context of mass communication that preachers often do. Khithabah become a popular paradigm that the escort mission dynamics of mass media propaganda with all kedakwahannya effectiveness. Often khithabah conducted limited spread Islamic ideology which incidentally is the transfer of ideas with a bunch of speeches recreational bandage which in turn offers the essence of propaganda about itself. However, the insertions are not rare in any recreational activity khithabah a bargaining power for their own propaganda and a lover of excellence in the Islamic world that in fact describe the nature of grace for the whole of nature.
Fundamentalisme Agama: Antara Fenomena Dakwah dan Kekerasan Atas Nama Agama
Authors: Dahlan Fahrurrozi
Published: July 2017

Fundamental Islam is a religious view that has its roots in orthodox understanding who interpret the religious texts in rigid, static and exclusive ways. Fundamentalism involves efforts to purify or reform the beliefs and practices of the followers according to their principles. The study of fundamentalism is a part in diversity in understanding a religion which has its own characteristics, not least reflected in their interpretation of the doctrine of rigid and literalist religion. This is motivated by several factors including; interpretation as it is important for them to maintain the purity of doctrine and practice. Next characteristic that the application of the doctrine as a whole is the only way to save mankind from ignorance. The conclusion of this study is the rise of fundamentalism in Islam, is actually a strong reaction on the growth of Islamic liberalism.
Konseling Islam: Studi terhadap Posisi dan Peta Keilmuan
Authors: Tajiri Hajir
Published: July 2017

Islamic counseling positions are in the debate between education, psychology and dakwah. All of them have a chance to develop Islamic counseling further. Educational counseling regards as one of the approaches in education and has had a very long history. Meanwhile counseling psychology claims as part of the work is the application of psychology and psychologists called counseling psychologists. In the middle of the debate, in Islamic science, it is dakwah science has been developed what is called irsyad and formula is not much different from counseling, just because it is in dakwah domain, it is shades of religious activity. Dakwah looked more entitled to counseling skills, because in dakwah, counseling activities that have been carried out by Muslims and fused with the dakwah activities.
HEMANGIOMAS E HEMANGIOSSARCOMAS EM CÃES: ESTUDO RETROSPECTIVO DE 192 CASOS (2002-2014)
Authors: Soares Nicolle Pereira , Medeiros Alessandra Aparecida , Szabó Matias Pablo Juan , Guimarães Ednaldo Carvalho , Fernandes Lígia Gundim , Santos Thaísa Reis dos
Published: July 2017

Resumo O hemangioma e o hemangiossarcoma são neoplasias mesenquimais originárias do endotélio vascular e o cão é o animal doméstico mais frequentemente acometido. Os registros do Laboratório de Patologia Animal do Hospital Veterinário da Universidade Federal de Uberlândia de 2002 a 2014 foram revisados. Os dados epidemiológicos e a frequência de cães com diagnóstico de hemangioma e hemangiossarcoma foram verificados e estatisticamente comparados. Foram identificados 64 casos de hemangioma e 128 casos de hemangiossarcoma. Para os hemangiomas, não houve diferença na frequência de acordo com sexo e raça. Quanto à localização, os hemangiomas não viscerais foram os mais frequentes em relação aos viscerais. As cadelas e animais adultos e idosos foram frequentemente acometidos por hemangiossarcoma, assim como a raça Pitbull. Os hemangiossarcomas apresentaram predominantemente tamanho médio e localização cutânea, ou seja, não visceral.
DYNAMIC CAPABILITIES IN AUTOMOTIVE POLLUTANTS REDUCTION TECHNOLOGIES: CASE STUDY
Authors: MESQUITA DANIEL LEITE , BORGES ALEX FERNANDO , SANTOS ANTÔNIO CARLOS DOS , SUGANO JOEL YUTAKA , VELOSO TAIS CASTRO
Published: July 2017

ABSTRACT Purpose: The aim of this paper is to analyze the dynamic capabilities related to the generation of pollutant reduction techniques according with Teece's proposition. In order to do so, we developed a case study in a Brazilian automaker. Originality/gap/relevance/implications: This paper discusses empirically aspects of creation of dynamic capabilities and innovations from its foundations. The originality of the study resides in a clearer understanding inside an organization the conception of dynamic capabilities and innovations through time. Key methodological aspects: In this paper, an automaker was studied, focusing on interviewers' interpretations concerning on the creation of reduction of pollutants technologies. The data collected were qualitative and they were analyzed through the technique of content analysis. Summary of key results: As main results, we observed that Integration and development capabilities were found and they were characterized as dynamic capabilities in the sense that, they are all based in the automaker's adaptation to its external environment. The path dependence of the automaker was also observed, through all the innovations that were created during the automaker's history towards more efficient and less pollutant vehicles. Key considerations/conclusions: Summarizing, the automaker seeks to ‘perceive' its dynamic capabilities from market's actions, since the organization has an historical path and also its R&D capabilities. So on the seizing phase of the Dynamic Capabilities, the organization seeks to ‘create value' to its customers.
Medidas de polarização da distribuição da renda e sua evolução no Brasil de 1995 a 2013
Authors: Hoffmann Rodolfo
Published: July 2017

Resumo As principais medidas de polarização em uso são criticamente avaliadas. Posteriormente, medidas de polarização baseadas no índice de Gini ou no índice T de Theil, considerando a divisão da distribuição da renda em dois ou três estratos, são aplicadas à distribuição da renda domiciliar per capita no Brasil, no período de 1995 a 2013. Constata-se clara tendência de redução da polarização, acompanhando a redução da desigualdade. Uma análise de dados regionais mostra o comportamento divergente da polarização da distribuição da renda no Distrito Federal. Finalmente, procura-se explicar os erros de trabalhos com resultados contrários.
Violência autoinfligida por intoxicação exógena em um serviço de urgência e emergência
Authors: Veloso Caique , Monteiro Claudete Ferreira de Souza , Veloso Lorena Uchôa Portela , Figueiredo Maria do Livramento Fortes , Fonseca Ruth Suelle Barros , Araújo Telma Maria Evangelista de , Machado Raylane da Silva
Published: July 2017

RESUMO Objetivo Analisar as violências autoinfligidas por intoxicação exógena notificadas em um serviço de saúde. Métodos Estudo epidemiológico, retrospectivo e analítico realizado em um serviço de urgência e emergência do município de Teresina, Piauí. Procedeu-se nos meses de janeiro e fevereiro de 2015, mediante análise de todos os casos de violência autoinfligida por intoxicação exógena notificados no Sistema de Informação de Agravos de Notificação, no período de 2009 a 2014. O teste qui-quadrado de Pearson foi utilizado na análise. Resultados Foram notificadas 277 vítimas de violência autoinfligida por intoxicação exógena, sendo que 10,5% morreram por suicídio. Houve associação entre o óbito e as variáveis idade, escolaridade, zona de ocorrência e tipo de exposição, assim como entre o tipo de exposição e a quantidade de agentes utilizados. Conclusão Os resultados fornecem subsídios para a definição de estratégias de prevenção considerando os grupos vulneráveis e a complexidade dos fatores associados à violência autoinfligida.
ASSESSMENT OF NUTRITIONAL STATUS OF CHILDREN AND ADOLESCENTS WITH SPASTIC QUADRIPLEGIC CEREBRAL PALSY
Authors: CASELLI Thaisa Barboza , LOMAZI Elizete Aparecida , MONTENEGRO Maria Augusta Santos , BELLOMO-BRANDÃO Maria Angela
Published: July 2017

ABSTRACT BACKGROUND: Due to several factors, such as gastrointestinal’s diseases and difficulty in feeding, children with Spastic Quadriplegic Cerebral Palsy tend to present nutritional deficits. OBJECTIVE: To assess the nutritional status of pediatric patients with Spastic Quadriplegic Cerebral Palsy according to reference curves for this population and with the measures of folds and circumferences, obtained by the upper arm circumference and triceps skin fold. METHODS: The data were obtained from: knee-height, estimated height, weight, upper arm circumference, and triceps skin fold. Values of folds and circumferences were compared with Frisancho, and specific curves for these patients were used as reference. The relationship between the values in the growth curve for healthy children, Z-Score, and comparison with the reference curve were verified by Fisher’s exact test. We adopted the significance level of 5%. RESULTS: We evaluated 54 patients. The mean age was 10.2 years, and 34 were male, 25 fed by gastrostomy and 29, orally. The frequency of low weight by the reference curve was 22.22%. More than half of the patients presented the parameters indicating lean mass below the 5th percentile. The height of all patients was classified as adequate for the age by the reference curve. CONCLUSION: Low weight was found in 22% of patients, and there is a greater tendency to present reduced muscle mass and increased fat mass, showing the need for evaluation and appropriate interventions for patients with Spastic Quadriplegic Cerebral Palsy.
Modelagem da qualidade da água do rio Poti em Teresina (PI)
Authors: Oliveira Filho Antônio Alves de , Lima Neto Iran Eduardo
Published: July 2017

RESUMO O crescimento desordenado da capital piauiense - marcado, sobretudo, pela ocupação habitacional às margens do rio Poti e pela existência de ligações clandestinas de esgoto bruto nas tubulações de drenagem pluvial - tem contribuído significativamente para a poluição das águas da bacia hidrográfica do rio Parnaíba (região semiárida do Brasil). A presente pesquisa tem como objetivo realizar a modelagem matemática da qualidade da água em um trecho de 36,8 km de extensão do rio Poti, com base na plataforma QUAL-UFMG. A pesquisa apresenta-se como o primeiro estudo envolvendo modelagem da qualidade da água no referido rio. Os componentes modelados foram: oxigênio dissolvido (OD), demanda bioquímica de oxigênio (DBO) e coliformes termotolerantes (CT). Os resultados das medições de campo indicaram desconformidades do parâmetro CT com relação à Resolução CONAMA nº 357/2005. A calibração dos coeficientes de decaimento para cada parâmetro resultou em desvios médios entre dados medidos e modelados de até 20% e coeficientes de eficiência de Nash-Sutcliffe superiores a 0,75, o que indica que o QUAL-UFMG pode ser utilizado como base para predição da qualidade da água em rios localizados em regiões semiáridas. O modelo calibrado também foi comparado aos dados de campo obtidos na literatura. Finalmente, foram realizadas simulações do modelo para diferentes cenários de vazão (mínimas e máximas), apresentando resultados coerentes e que podem ser utilizados para a gestão dos recursos hídricos do estado do Piauí.
Aplicação de um Programa de Ensino de Palavras em Libras Utilizando Tecnologia de Realidade Aumentada
Authors: CARVALHO Dariel de , MANZINI Eduardo José
Published: July 2017

RESUMO: a Língua Brasileira de Sinais (Libras) é uma língua gestual que abrange as necessidades da comunidade surda e, instituída no Brasil como língua oficial; é ensinada em instituições de atendimento a alunos com surdez. Em vista disso, objetivou-se verificar a eficácia na aplicação de um programa de ensino de um grupo de palavras em Libras por meio de um software com tecnologia de realidade aumentada, avaliando o repertório inicial e final de alunos com surdez. Participaram deste estudo oito alunos com idades entre sete e 16 anos com surdez. Estes foram submetidos a avaliações inicial e final, nas quais, pudemos obter um panorama geral das relações e conhecimento das palavras. A intervenção foi subdividida em cinco sessões para o ensino de 15 palavras, sendo três palavras em cada passo de ensino. Após o emprego do software, foram aplicadas avaliações de sondagem com o objetivo de acompanhar o ensino dessas palavras. Os resultados obtidos apontam para a dificuldade em selecionarem letras do alfabeto e construírem o nome de uma determinada palavra. Em relação ao sinal, foi observado que os participantes dominavam os sinais relacionados e apresentavam dificuldades em identificar seus correspondentes: figura e palavra escrita em Língua Portuguesa. Foi evidenciado a dificuldade dos participantes, de memorizar a sequência correta de letras que compõe uma palavra em Língua Portuguesa. A aplicação do recurso pode não só ensinar palavras e relações novas, como também ampliar a elaboração de estratégias para o ensino planejado em Educação Especial.
Revisão Sistemática das Pesquisas Colaborativas em Educação Especial na Perspectiva da Inclusão Escolar no Brasil
Authors: SOUZA Christianne Thatiana Ramos de , MENDES Eniceia Gonçalves
Published: July 2017

RESUMO: a implementação da política de inclusão escolar no Brasil tem produzido mudanças que impactam desde a formação docente até a atenção dada aos alunos do público-alvo da Educação Especial nos contextos escolares. Essas modificações vêm sendo acompanhadas por investigações científicas que buscam evidenciar as características desse processo e os problemas surgidos a partir dele. Aos poucos, os pesquisadores começaram a assumir um papel mais ativo nesse processo de transformação do cotidiano escolar inclusivo, o que levou a um aumento na quantidade de pesquisas colaborativas realizadas na área da Educação Especial na perspectiva da inclusão escolar. Neste sentido, nosso objetivo foi descrever e analisar o que tem sido produzido pelas pesquisas-ação colaborativas desenvolvidas na área da Educação Especial na perspectiva da inclusão escolar, no período de 2008 a 2015, tomando como fonte os resumos das teses e dissertações nacionais. Os descritores utilizados foram: pesquisa participante; pesquisa ação; pesquisa colaborativa; pesquisa-ação colaborativa; pesquisa ação crítico-colaborativa; inclusão escolar; e educação especial. A busca foi realizada na base de dados da Biblioteca Digital Brasileira de Teses e Dissertações. Os resumos de 41 trabalhos foram analisados com base em um protocolo elaborado para esta investigação. A caracterização das pesquisas evidenciou suas contribuições para a formação dos profissionais que atuam na escola junto aos alunos do público-alvo da Educação Especial; para a inclusão escolar desses alunos; além de apontar as lacunas e possíveis sugestões para a solução de problemas identificados no campo da Educação Especial e da Inclusão Escolar.
Endogenous Heat-Shock Protein Induction with or Without Radiofrequency Ablation or Cryoablation in Patients with Stage IV Melanoma
Authors: Domingo-Musibay Evidio , Heun James M. , Nevala Wendy K. , Callstrom Matthew , Atwell Thomas , Galanis Evanthia , Erickson Lori A. , Markovic Svetomir N.
Published: July 2017

Lessons Learned

Percutaneous thermal ablation combined with in situ granulocyte-macrophage colony-stimulating factor cytokine therapy was technically feasible and well tolerated. No significant clinical or immunologic responses were seen.

Background

Melanoma tumor-derived heat-shock proteins (HSPs) and HSP-peptide complexes can elicit protective antitumor responses. The granulocyte-macrophage colony-stimulating factor (GM-CSF) chemokine can also promote uptake and processing by professional antigen presenting cells (APCs). On this basis, we designed a pilot study of percutaneous thermal ablation as a means to induce heat-shock protein vaccination plus GM-CSF to determine safety and preliminary antitumor activity of this combination.

Materials and Methods

This study was designed to assess overall safety of percutaneous ablation combined with GM-CSF for unresectable, metastatic melanoma including uveal and mucosal types. All patients received heat-shock therapy (42°C for 30 minutes), then received one of three treatments: (a) intralesional GM-CSF (500 mcg standard dose); (b) radiofrequency ablation (RFA) + GM-CSF; or (c) cryoablation plus GM-CSF. The primary endpoint of the study was the induction of endogenous HSP70 and melanoma-specific cytotoxic T lymphocytes (CTL).

Results

Nine patients (three per study arm) were enrolled. No dose-limiting toxicity was observed as specified per protocol. All patients developed progressive disease and went on to receive alternative therapy. Median overall survival (OS) was 8.2 months (95% confidence interval [CI] 2–17.2). The study was not powered to detect a difference in clinical outcome among treatment groups.

Conclusion

Percutaneous thermal ablation plus GM-CSF was well tolerated, technically feasible, and demonstrated an acceptable adverse event profile comparable to conventional RFA and cryoablation. While HSP70 was induced following therapy, the degree of HSP70 elevation was not associated with clinical outcome or induced CTL responses. While percutaneous thermal ablation plus GM-CSF combinations including checkpoint inhibitors could be considered in future studies, the use of GM-CSF remains experimental and for use in the context of clinical trials.
Produção leiteira no Brasil e características da bovinocultura leiteira no Rio Grande do Sul
Authors: Matte Júnior Alexandre Aloys , Jung Carlos Fernando
Published: July 2017

Este artigo apresenta uma revisão sistemática que teve por finalidade evidenciar e analisar as contribuições advindas de pesquisas sobre a produção leiteira no Brasil, em especial, a estrutura da produção da bovinocultura leiteira no estado do Rio Grande do Sulo. Para tanto, foram selecionados 28 publicações nas bases Scielo, Periódicos CAPES, Directory of Open Access Journals (DOAJ), e publicações da Embrapa - Pesquisa Agropecuária e Fundação de Economia e Estatística (FEE) do Rio Grande do Sul. O estudo mostrou que 48% das publicações têm origem na Região Sul do Brasil. As publicações ressaltam a importância da produção de leite para a economia brasileira e para o desenvolvimento social das regiões produtoras. A análise também evidenciou a necessidade de investimentos em qualificação dos meios de produção, recursos humanos e produto final.
Adverse drug reaction reports in Iceland from 2013 to 2016. A comparison with other Nordic countries
Authors:   Landspitali University Hospital of Iceland, Jónsdóttir Sara Skúlína , Ólafsdóttir Sigríður ,   Icelandic Medicines Agency, Guðmundsdóttir Hrefna ,   Landspitali University Hospital of Iceland‚ Icelandic Medicines Agency
Published: July 2017

Introduction: Information regarding adverse drug reactions (ADRs) of new medications is based on clinical studies of selected populations. The reporting of ADRs from real-life use following the marketing of new active substances is instrumental for the continuous evaluation of their benefit-risk balance. The aim of this study was to determine the number and nature of ADR reports in Iceland and compare with other Nordic countries. Materials and methods: Reports of ADRs from 2013 to 2016 were examined using the Icelandic Medicines Agency´s database. The total number and seriousness of ADRs by ATC-classification of drugs were compared with data published in the 2013 to 2015 annual reports from the Swedish, Danish and Norwegian Medicines Agencies. Comparison of sales between countries was examined. Results: The number of ADR reports in Iceland was between 36 to 104 per 100 thousand inhabitants/year, with less than 10% defined as serious. This compares to 58 to 133 ADR reports per 100 thousand inhabitants in the other Nordic countries, with 38% to 64% of ADRs classified as serious. In Iceland, ADR reports were more common for medications in ATC-class A and less common for classes B, J and L compared to the other Nordic countries. Sales of medications were comparable between these nations. Conclusion: There is great variability in the number of ADRs reported annually in Iceland. The drugs reported are within different ATC-classes and the proportion of serious ADRs is low compared to the other Nordic countries. This is not explained by different sales volumes.
Directed self-assembly software for single cell deposition
Authors: C. Sklare Samuel , L. Richey Winona , T. Vinson Benjamin , B. Chrisey Douglas
Published: July 2017

Laser direct-write (LDW) bioprinting methods offer a diverse set of tools to design experiments, fabricate tissue constructs and to cellular microenvironments all in a CAD/CAM manner. To date, we have just scratched the surface of the system’s potential and for LDW to be utilized to its fullest, there are many distinct hardware and software components that must be integrated and communicate seamlessly. In this perspective article, we detail the development of novel graphical user interface (GUI) software to improve LDW capability and functionality. The main modules in the control software correspond to cell transfer, microbead fabrication, and micromachining. The modules make the control of each of these features, and the management of printing programs that utilize one or more features, to be facile. The software also addresses problems related to construct scale-up, print speed, experimental conditions, and management of sensor data. The control software and possibilities for integrated sensor data are presented.
Motivação no Ensino Superior: Estratégias e Desafios
Authors: De Oliveira Êmila Silveira
Published: July 2017

O processo de educação é necessário na formação dos indivíduos, através dele, objetiva-se contribuir com a formação de indivíduos autônomos, críticos, criativos e ativos na sociedade em que vivem. Ao contrário do que pensamos, os conhecidos problemas educacionais do nosso país, não estão restritos apenas à educação básica e podem ser facilmente visualizados também no ensino superior. Portanto, a partir da necessidade de se conhecer, debater e colocar em prática estratégias de ensino que contribuam com a melhora da qualidade de ensino e da aprendizagem no ensino superior no Brasil, esse trabalho teve por objetivo, discutir a respeito da utilização da motivação como estratégia fundamental para a efetivação da aprendizagem de acadêmicos. Bem como, compreender as principais teorias motivacionais e a sua relação com a aprendizagem, conhecer o papel do professor no ensino superior e, através da compreensão da importância da atuação desse profissional, estabelecer estratégias de ensino e de motivação que auxiliem no aprendizado de graduandos.
¿Obedecer las leyes?: utilitarismo, retórica forense y autoridad en el Critón de Platón (50a6-50b5)
Authors: Magoja Eduardo Esteban
Published: July 2017

En el Critón de Platón se instala un interesante argumento utilitarista para justificar la obligación política de los ciudadanos. El argumento sostiene que la violación de las leyes lleva a la destrucción de cualquier sistema jurídico y acarrea resultados perjudiciales para los miembros de la comunidad (50a6-50c). En este trabajo realizaremos un análisis crítico del argumento bajo los postulados de tres corrientes utilitaristas: el utilitarismo de acto, la generalización utilitarista y el utilitarismo de regla. Veremos cómo esta clase de argumentación presenta algunos inconvenientes a la hora de justificar la obediencia al derecho. Una vez realizado este estudio se propondrá otra interpretación complementaria sobre el significado del pasaje, en la que se destacará su costado retórico forense y la idea de la autoridad del derecho.
Assessment of rainwater harvesting tank size for livestock use
Authors: Londra P. A. , Theocharis A. T. , Baltas E. , Tsihrintzis V. A.
Published: July 2017

Rainwater harvesting is an ancient practice aiming to cover water needs for domestic, irrigation and livestock uses. In this study, the rainwater harvesting tank size was investigated to meet five water-need levels of a mixed goat–sheep farm using a daily water balance method. This method was applied using daily rainfall data for a period of 16 years from six meteorological stations in selected regions of Greece, characterized by different rainfall regimes and well-developed livestock activity, taking into account, among other parameters, the water needs of animals, the rainwater collection area and the runoff coefficient. There is a great variation in the rainwater harvesting tank size among the stations studied due to differences in the annual rainfall and the maximum dry period. Results showed that meeting full demands (100% reliability) requires tank sizes ranging from 20 m3 for short dry period stations–low demand scenario (320 L/day) to 115 m3 for long dry period stations–high demand scenario (576 L/day), assuming a maximum collection area of 450 m2. Correspondingly, reliability analysis showed that very high values of reliability (95%) can be obtained with tank sizes ranging from 10 to 85 m3, respectively.