bluuebunny/crossref_metadata_2025 huggingface dataset:
How I Deal With Breast Cancer: Iranian Women Survivors Coping Strategies - Content Analysis
Authors: Manouchehri E , Taghipour A , Ebadi A , Shandiz F Homaei , Roudsari Robab Latifnejad
Published: January 2022

Background: Breast cancer is the most frequent cancer in Iran. Understanding the coping strategies employed by cancer survivors can provide valuable information for designing interventions to help them adapt to their problems produced by cancer and its treatment. This study aimed to explore the coping strategies of BC survivors in Iran.Methods: This qualitative study was conducted in Mashhad, Northeast of Iran, between April to December 2021. 14 breast cancer survivors were selected through purposive sampling method. The data were collected using semi-structured interviews. Data were analyzed using conventional content analysis adopted by Graneheim & Lundman. MAXQDA 12 software, was used for data organization. Components of trustworthiness including credibility, dependability, confirmability and transferability were considered.Results: The main themes which emerged from participants' data analysis were "behavioral coping strategies" and "emotional coping strategies". Behavioral strategies such as change nutritional habits, improving lifestyle, trying to stay active, seeking help for improvement of physical and mental needs and efforts to increase knowledge and literacy about BC. The psychological strategies were denying the breast cancer, psychological empowerment, spirituality and seeking help of family and relatives. Conclusion: Our findings provide in-depth understanding of Iranian women’s strategies for coping with BC. The qualified teams of psychiatrics, oncologists and reproductive health specialists need to contribute significantly to an upgraded coping of patients to cancer that could lead to higher quality of life.
MicroRNA-223 Downregulation Promotes HBx-Induced Podocyte Pyroptosis by Targeting the NLRP3 Inflammasome
Authors: YU Yani , DONG Hui , ZHANG Yue , SUN Jingyi , LI Baoshuang , CHEN Yueqi , FENG Moxuan , YANG Xiaoqian , GAO Shengbo , JIANG Wei
Published: January 2022

Hepatitis B virus (HBV) and its related protein, HBV X (HBx), play an important role in podocyte injury in HBV-associated glomerulonephritis (HBV-GN). MiR-223 is expressed in several diseases, including HBV-associated disease, while nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome plays a major role in pyroptosis. This study aims to determine the potential function and related mechanism of miR-223 in HBx-induced podocyte pyroptosis. We observed that the results of polymerase chain reaction indicated that miR-223 was downregulated in HBx-transfected podocytes. Transfection of miR-223 mimic eliminated the expression of NLRP3 inflammasome and its related cytokines released by NLRP3 overexpression. Moreover, the transfection of HBx and NLRP3-overexpressing plasmids increased the expression of pyroptosis-related proteins especially in the presence of miR-223 inhibitors. In conclusion, miR-223 downregulation plays an important role in HBx-induced podocyte pyroptosis by targeting the NLRP3 inflammasome, suggesting that miR-223 is a potential therapeutic target for alleviating HBV-GN inflammation.
Functional Status and Its Related Factors Among Stroke Survivors in Rehabilitation Departments of Hospitals in Shenzhen, China
Authors: Zhou Jing , Liu Fang , Zhou Mingchao , Long Jianjun , Zha Fubing , Chen Miaoling , Li Jiehui , Yang Qingqing , Zhang Zeyu , Wang Yulong
Published: January 2022

Background: Many stroke survivors have multiple chronic diseases and complications, coupled with various other factors which may affect their functional status. We aimed to investigate the factors associated with poor functional status in hospitalized patients with stroke in Shenzhen, China.Methods: This is a cross-sectional study. Data on 646 patients with stroke were recruited from four urban hospitals using cluster sampling. The Longshi Scale was used to assess the functional status of stroke survivors. Explanatory variables, i.e. factors affecting functional status, included demographic, lifestyle factors, complications, and chronic conditions. The ordinal logistic regression model was used to investigate factors associated with poor functional status. Results: Stroke survivors with poor functional status accounted for 72.14% and were assessed as the bedridden group based on the Longshi scale, 21.67% of patients with moderate functional limitation were assessed as the domestic group and 6.19% of the patients with mild functional restriction was assessed as the community group. The highest dependence was noted for feeding (73.39%), bowel and bladder management (69.74%), and bedtime entertainment (69.53%) among the bedridden group, and housework (74.29%) among the domestic group. In the adjusted model, patients who were in older age groups (odds ratio [OR] = 2.39, 95% CI: 1.55–3.80), female (OR = 1.73, 95% CI: 1.08–2.77), duration of stroke more than 12 months (OR = 1.94, 95% CI: 1.28–2.95), with pulmonary infection (OR = 10.91, 95% CI: 5.81–20.50), and with deep venous thrombosis (OR = 3.00, 95% CI: 1.28–7.04) had almost or more than two times the risk of poorer functioning.Conclusions: Our study found that 72.14% of stroke survivors had poor functional status, 21.67% and 6.19% of stroke survivors had moderate functional limitations and mild functional restrictions in rehabilitation settings. The older age bracket (age ≥ 60) and females were more likely to exhibit poor functioning. Pulmonary infection and deep venous thrombosis, both common post-stroke complications, were related to the increased chance of dependence. Therefore, interventions aimed at treating or preventing pulmonary infection and deep vein thrombosis need to contribute to addressing these circumstances and subsequent dysfunction after stroke.
Lung and Colon Cancer Classification Using Medical Imaging : A Feature Engineering Approach
Authors: Chehade Aya Hage , Abdallah Nassib , Marion Jean-Marie , Oueidat Mohamad , Chauvet Pierre
Published: January 2022

Lung and colon cancers are the most common causes of death. Their simultaneous occurrence is uncommon, however, in the absence of early diagnosis, the metastasis of cancer cells is very high between these two organs. Currently, histopathological diagnosis and appropriate treatment are the only possibility to improve the chances of survival and reduce cancer mortality. Using artificial intelligence in the histopathological diagnosis of colon and lung cancer can provide significant help to specialists in identifying cases of colon and lung cancers with less effort, time and cost. The objective of this study is to set up a computer-aided diagnostic system that can accurately classify five types of colon and lung tissues (two classes for colon cancer and three classes for lung cancer) by analyzing their histopathological images. Using machine learning, features engineering and image processing techniques, the five models XGBoost, SVM, RF, LDA and MLP were used to perform the classification of histopathological images of lung and colon cancers that were acquired from the LC25000 dataset. The main advantage of using machine learning models is that they allow for better interpretability of the classification model since they are based on feature engineering; however, deep learning models are black box networks whose working is very difficult to understand due to the complex network design. The acquired experimental results show that machine learning models give satisfactory results and are very precise in identifying classes of lung and colon cancer subtypes. The XGBoost model gave the best performance with an accuracy of 99% and a F1-score of 98.8%. The implementation and the development of this model will help healthcare specialists identify types of colon and lung cancers. The code will be available upon request.
Integrated Product, Process and Manufacturing System Development for Multifunctional Micromachine Tool
Authors: Cortés Daniel , Ramírez José , Medina Jorge , Molina Arturo
Published: January 2022

Novel practices in the formation of students are encouraged to be multidisciplinary which in fact, allows them to better understand the behaviour of systems. This skill allows them to identify existing needs that impact multiple areas, both for an organization and to complement their entrepreneurial training. In this work, there is exposed a reference framework that arose to aid in the innovative design process among the manufacturing sector, it seeks to stretch the gap between conceptualization and implementation for engineering projects. Furthermore, the formation of the learners is enriched due to the breakdown of complex systems into entities as it gathers existing knowledge and provides structure to systematize the development process, allocate problems and provide feedback. Thus, design stages are detailed, engineering stages are described, and a toolbox is presented to guide designers into their task. The methodology has been tested under multidisciplinary projects in different time lapses, observing a positive impact in the formation of participants, as it guarantees the inclusion of desired attributes, documentation and milestones in the scenario being developed. In this article, there are described three case studies. Findings when developing using the methodology shows a structural, documented process followed by the designers, capable of recognizing the abilities acquired and reinforced skills, documented entities corresponding to what is developed at the end of the projects and time of deployment is enhanced.
Amisulpride Augmentation Therapy Improves Cognitive Performance and Psychopathology in Clozapine-resistant Treatment-refractory Schizophrenia (CTRS): a 12-week Randomized, Double-blind, Placebo-controlled Trial
Authors: Li Zezhi , Zhu Minghuan , Liu Zhenjing , Hu Qiongyue , Yang Jiayu , Jin Ying , Zhu Na , Huang Ying , Shi Dianhong , Liu Minjia , Zhao Lei , Lv Qinyu , Yi Zhenghui , Wu Fengchun
Published: January 2022

BackgroundAlthough clozapine is an effective option for treatment-resistant schizophrenia (TRS), there are still 1/3 to 1/2 of TRS patients who do not respond to clozapine. The main purposes of this randomized, double-blind, placebo-controlled trial was to explore the amisulpride augmentation efficacy on the psychopathological symptoms and cognitive function of CTRS patients. MethodsA total of 80 patients were recruited and randomly assigned to receive an initial clozapine plus amisulpride or clozapine plus placebo. Positive and Negative Syndrome Scale (PANSS), Scale for the Assessment of Negative Symptoms (SANS), Clinical Global Impression (CGI) scale scores, Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), Treatment Emergent Symptom Scale (TESS), laboratory measurements and electrocardiograms (ECG) were performed at baseline, week 6, and week 12. ResultsCompared with clozapine plus placebo group, clozapine plus amisulpride had lower PANSS total score, positive subscore and general psychopathology subscore at week 6 and week 12 (all p Bonferroni< 0.01). Furthermore, compared with clozapine plus placebo group, clozapine plus amisulpride showed improved RBANS language score at week 12 (p Bonferroni< 0.001). Clozapine plus amisulpride group had a higher treatment response rate (p = 0.04), lower scores of CGI severity (CGI-S) and CGI efficacy (CGI-E) at week 6 and week 12 than clozapine plus placebo (all p Bonferroni< 0.05). There were no differences in BMI, QT intervals or laboratory measurements between the groups. Our results demonstrate that amisulpride augmentation therapy can safely improve the psychiatric symptoms and cognitive performance of CTRS patients. ConclusionsOur study indicates that amisulpride augmentation therapy has important clinical significance for the treatment of CTRS to improve clinical symptoms and cognitive function with tolerability and safety.Trial registrationClinicaltrials.gov identifier- NCT03652974. Registered 31 August 2018, https://clinicaltrials.gov/ct2/show/NCT03652974
First Report of Rickettsia Asembonensis in Small Ruminants
Authors: Low Van Lun , Azhar Siti Sarah , Tan Tiong Kai , Bathmanaban Premaalatha , AbuBakar Sazaly , Chandrawathani Panchadcharam , Nizamuddin Hassan Nizam Quaza , Hanim Mohd Saeid Faizah , Akma Ngah Hamid , Norlizan Mohd Noor , Lim Yvonne Ai Lian
Published: January 2022

Rickettsioses is an emerging infectious disease in Southeast Asia caused by different organisms in the Rickettsiae bacterial tribe, a gram-negative obligate intracellular bacterium. There is limited information regarding the vertebrate hosts of Rickettsia spp. This study aims to detect and identify Rickettsia agents present in wildlife and domesticated animals in Malaysia using Polymerase Chain Reaction (PCR) and sequencing approach with phylogenetic analysis. Rickettsia sp. was detected in 2 (0.67%) of 300 animal blood samples. The positive samples were derived from a goat (5.56% of 18) and a sheep (2.22% of 45). Based on the analysis of the Rickettsia citrate synthase gene (gltA), both sequences demonstrated 99.64% sequence similarity to Rickettsia asembonensis, a species that is known to infect humans and macaques. This study reported for the first time the detection of R. asembonensis in sheep and goats in Malaysian farms, suggesting this species may be adapting in a wider range of animals, specifically farm animals, therefore, poses a zoonotic threat to the local populace particularly to the farm workers or animal handlers. The low infection rate of this pathogen yet is of public health importance highlighted the needs of continuous surveillance of emerging and reemerging pathogens among animal reservoirs.
The immunosenescence and lipotoxicity in thyrotoxicosis mice
Authors: Feng Qin
Published: January 2022

COVID-19 is a worldwide outbreak now, and it is found to be age-related. Immunosenescence may be a predisposing and severe factor for COVID-19. Besides, many infectious diseases in clinic are age-related, and elderly patients have longer hospitalization and worse prognosis. Therefore, finding suitable aging models is of great significance for fighting aging related diseases and promoting the prognosis of elderly patients. In this study, the relationship between thyrotoxicosis and aging was investigated by routine detection and serum metabonomics in mice. The results of routine blood test and flow cytometry showed significant decrease in neutrophils, lymphocytes, CD4+/CD8+ and CD4+IFN-γ + lymphocytes in thyrotoxicosis mice. Biochemical examination combined with serum metabolomics analysis showed that serious disorder of lipid metabolism may be one of the causes of immunosenescence, including lower cholesterol levels, lower levels of VD and bile acids, high level of glucocorticoids, triglycerides, free fatty acids, Sphingolipids and decrease of Docosanoids, especially DPA. This study proves that thyrotoxicosis mice are an accelerated aging model. In present study, the main performance is immunosenescence, which may be due to lipotoxicity, suggesting that the immunosenescence state can be adjusted by improving lipotoxicity, whether anti thyroxine or not. However, there are other manifestations of thyroid toxicity mouse model simulating aging, such as organ aging, which need to continue to be studied by means of system biology to provide more comprehensive evidence.
Critical SWOT analysis of fresh fruit handling practices by traders in Uganda’s Capital City. A rapid cross-sectional study
Authors: Nakayiza Suzan , Walekhwa Abel Wilson , Tumwine Gabriel , Muleme James , Musewa Angella
Published: January 2022

Poor fruit handling practices causes physical damage to fruits and exposes them to pathogenic microbial contamination with Salmonella spp, E. coli and Vibrio spp. These contribute to food borne illnesses such as Salmonellosis, Shigellosis, Cholera, E. coli O157:H7 infection Campylobacteriosis among others. An estimated 14 percent of all diseases registered at health centers are food borne related in Uganda making this a public health concern. The economic burden of foodborne diseases was estimated at about 300 million United States Dollars in 2016. A rapid cross-sectional study was conducted using a SWOT framework to understand the fruit handling practices by traders in one of the markets in Uganda’s Capital City (Kampala). Our study showed that there existed some strengths such as Presence of an established market leadership and presence of organized registered and unregistered trade and social groups. Furthermore, there existed weaknesses that needed immediate attention such as (a) lack of clean water, (b) selling fruits on dirty market floor which exposes consumers to contaminated fruits, (c) disposal of spoilt fruits in open waste areas contaminates the soil, clogs drainage channels, creates a bad smell in the market and attracts rodents to feed on disposed fruits. We therefore recommend, establishing a ‘One Health’ market task force made up of traders, suppliers, farmers, consumers, local council, public health scientists and Kampala Capital City Authority (KCCA) that can work with Ministry of Local Governments and Ministry of Health to train traders to implement appropriate fruit handling practices as detailed in KCCA market laws. The One Health task force can work with Ministry of Science and Technology to design and develop tools such as insulated fruit crates, raised fruit stands, and closed waste bins that could be used by market traders to improve fruit hygiene practices. The One health market taskforce will be in position to link with private international organizations such WASH international to draft proposals to provision for free clean water for the market which could improve fruit hygiene and market sanitation.
Vesical Gossypiboma with Urethral Migration Causing Acute Urinary Retention: A Case Report and Literature Review
Authors: Gebreselassie Kaleab Habtemichael , Mummed Ferid Ousman , Gebrehiwot Fitsum Gebreegziabher , Adam Mubarek Bargicho , Adam Ramzi Yesuf , Issack Feysel Hassen
Published: January 2022

Introduction:

Vesical gossypiboma is a retained surgical sponge in the urinary bladder following abdominal or pelvic surgery. It is probably under-reported due to medico-legal issues. It usually poses a diagnostic challenge to clinicians. A high index of suspicion is essential to make a timely diagnosis.
Case Presentation:

We present a case of vesical gossypiboma in a 64-year-old male patient who presented with a history of persistent lower urinary tract symptoms (LUTS) and acute urinary retention following trans-vesical prostatectomy. The urinary retention was relieved by a suprapubic cystostomy. On cystoscopic examination, a large whitish spongiform structure in the urethra and bladder was revealed. A gentle attempt of cystoscopic removal was failed. At exploration, a retained surgical sponge was revealed and removed from the bladder. Postoperatively, the patient reported improvement of symptoms and was passing urine normally.
Clinical Discussion:

Vesical gossypiboma is relatively rare as very few isolated cases have been reported, and its migration through the urethra is even rarer. Patients with intravesical gossypiboma may manifest with either acute or chronic symptoms due to complications. Gossypiboma is an avoidable condition, and its occurrence can be prevented by thorough exploration of the surgical site and count of surgical materials at the end of the procedure.
Conclusion

Vesical gossypiboma should be considered as a differential diagnosis in patients with persistent LUTS following open bladder or prostate surgery. Open surgical removal is one of the feasible treatment options. But prevention is a preferable solution.
Identification of Multi-omics Biomarkers and Construction of the Novel Prognostic Model for Hepatocellular Carcinoma
Authors: Yan Xiaokai , Xiao Chiying , Yue Kunyan , Chen Min , Zhou Hang , Liu Xiao
Published: January 2022

Background: Change in the genome plays a crucial role in cancerogenesis and many biomarkers can be used as effective prognostic indicators in diverse tumors. Currently, although many studies have constructed some predictive models for hepatocellular carcinoma (HCC) based on molecular signatures, the performance of which is unsatisfactory. To fill this shortcoming, we hope to construct a novel and accurate prognostic model with multi-omics data to guide prognostic assessments of HCC. Methods: The TCGA training set was used to identify crucial biomarkers and construct single-omic prognostic models through difference analysis, univariate Cox, and LASSO/stepwise Cox analysis. Then the performances of single-omic models were evaluated and validated through survival analysis, Harrell’s concordance index (C-index), and receiver operating characteristic (ROC) curve, in the TCGA test set and external cohorts. Besides, a comprehensive model based on multi-omics data was constructed via multiple Cox analysis, and the performance of which was evaluated in the TCGA training set and TCGA test set. Results: We identified 16 key mRNAs, 20 key lncRNAs, 5 key miRNAs, 5 key CNV genes, and 7 key SNPs which were significantly associated with the prognosis of HCC, and constructed 5 single-omic models which showed relatively good performance in prognostic prediction with c-index ranged from 0.63 to 0.75 in the TCGA training set and test set. Besides, we validated the mRNA model and the SNP model in two independent external datasets respectively, and good discriminating abilities were observed through survival analysis (P < 0.05). Moreover, the multi-omics model based on mRNA, lncRNA, miRNA, CNV, and SNP information presented a quite strong predictive ability with c-index over 0.80 and all AUC values at 1,3,5-years more than 0.84.Conclusion: In this study, we identified many biomarkers that may help study underlying carcinogenesis mechanisms in HCC, and constructed five single-omic models and an integrated multi-omics model that may provide effective and reliable guides for prognosis assessment and treatment decision-making.
Children with Strabismus and Amblyopia Presented Abnormal Spontaneous Brain Activities Measured through Fractional Amplitude of Low-frequency Fluctuation (fALFF)
Authors: Shi Yi-Dan , Liu Li-Qi , Liang Rong-Bin , Ge Qian-Min , Li Qiu-Yu , Pan Yi-Cong , Shu Hui-Ye , Zhang Li-Juan , Shao Yi
Published: January 2022

Purpose: Based on fMRI technology, we explored whether children with strabismus and amblyopia (SA) showed significant change in fractional amplitude of low-frequency fluctuation (fALFF) values in specific brain regions compared with healthy controls, and whether this change could point to the clinical manifestations and pathogenesis of children with strabismus to a certain extent.Methods: We enrolled 23 children with SA and same number matched healthy control in the ophthalmology department of the First Affiliated Hospital of Nanchang University, and the whole brain was scanned by rs-fMRI. The fALFF value of each brain area was derived to examine whether there is a statistical difference in the two groups. Meanwhile, ROC curve was made in a view to evaluate whether this difference proves useful as a diagnostic index. Finally, analyze whether changes in the fALFF value of some specific brain regions are related to clinical manifestations.Results: report to HCs children with SA presented a decreased fALFF values in left temporal pole: the superior temporal gyrus, right middle temporal gyrus, right superior frontal gyrus, right supplementary motor area. Meanwhile, they also showed higher fALFF values in specific brain areas, which included left precentral gyrus, left inferior Parietal, left Precuneus.Conclusion: Children with SA showed abnormal fALFF values in different brain regions. Most of these regions were allocated to the visual formation pathway. The eye movement-related pathway or other visual-related pathways, suggesting the pathological mechanism of the patient.
LncRNA-KCNQ1OT1 Promotes the Odontoblastic Differentiation of Dental Pulp Stem Cells via Regulating miR-153-3p/RUNX2 Axis
Authors: Lu Xiaohui , Zhang Jiawen , Lu Yuanzhou , Xing Jing , Lian Min , Feng Guijuan , Huang Dan , Wang Chenfei , Shen Nimei , Feng Xingmei
Published: January 2022

Background and Objective: Long non-coding RNAs (LncRNAs) play a key role in the odontoblastic differentiation. This study aimed to explore the role of LncRNA-KCNQ1OT1 in the odontoblastic differentiation of human dental pulp stem cells (DPSCs) and its possible mechanism. Methods: The expression of LncRNA-KCNQ1OT1, miR-153-3p, RUNX2 in the odontoblastic differentiation was detected by qRT-PCR. Interaction between LncRNA-KCNQ1OT1 and miR-153-3p and interaction between miR-153-3p and RUNX2 were detected by dual-luciferase assay. The cell viability of DPSCs was detected by cell counting kit-8 (CCK-8), and the effect of LncRNA-KCNQ1OT1 and miR-153-3p on the odontoblastic differentiation of DPSCs was observed by alizarin red staining, alkaline phosphatase (ALP) activity assay and Western blot for RUNX2, DSPP, DMP-1. Results: During odontoblastic differentiation of DPSCs, the expression of LncRNA-KCNQ1OT1 increased, miR-153-3p expression decreased, and RUNX2 expression increased. Dual-luciferase assay showed that LncRNA-KCNQ1OT1 sponges miR-153-3p and miR-153-3p targets on RUNX2. After LncRNA-KCNQ1OT1 and miR-153-3p expressions of DPSCs were changed, the cell viability was not notably changed, but the odontoblastic differentiation was notably changed which was confirmed with alizarin red staining, ALP activity and Western blot for RUNX2, DSPP, DMP-1. Conclusion: LncRNA-KCNQ1OT1 promotes the odontoblastic differentiation of DPSCs via regulating miR-153-3p/RUNX2 axis, which may provide a therapeutic clue for odontogenesis.
A correlação entre a leptospirose e as condições socioambientais: ênfase na região do Cariri – CE, Brasil
Authors: Bezerra Agnes Jennine Alves , Viana Lucas Batista , Feitosa Marina Tavares , Alves Rayka Dantas Rodrigues , Leite Daniel Gonçalves , Malheiro Djailson Ricardo
Published: January 2022

O presente artigo tem como objetivo estudar a Leptospirose, além de entender como está concentrada sua disseminação pelas regiões brasileiras, em especial a região do Cariri cearense, a fim de associar o ciclo de vida da bactéria e sua relação de contágio com a condição socioambiental da população em geral. Foi analisada a relação do número de residências com esgoto a céu aberto e sua interferência com a leptospirose, como a água das enchentes que fica acumulada devido à falta de uma drenagem adequada contribui para o aumento da doença. Nesse estudo também foi possível observar a escassez de estudos e artigos científicos que procurarem pesquisar e se aprofundar sobre o assunto na área da região do Cariri. Desse modo, foi possível observar a falta de atenção básica e políticas públicas por parte do governo, seja ele municipal ou estadual, em buscar promover uma condição de vida favorável para sua população, seja ela urbana ou rural. Em especial foi observado a falta de atenção a pessoas de uma certa faixa etária, tendo a maior média de contágio. Dessa forma, viu-se a necessidade de questionar e buscar se aprofundar cada vez mais sobre a questão, procurando sempre informar a população, a fim de que possa se evitar que o número de pessoas infectadas amplie.
Queratocisto odontogênico: índice de recorrência em função do tipo de tratamento
Authors: Oliveira Mateus Henrique de , Aguillera Maisa de Oliveira , Santos Muryllo Eduardo Sales dos , Figueiredo Francielly Thomas , Nejaim Yuri , Antunes Daniella Moraes , Silva Julio Cesar Leite da , Melo Rosana Leite de , Gaetti Jardim Ellen Cristina
Published: January 2022

O queratocisto odontogênico é um cisto de desenvolvimento com alto poder de recorrência que acomete principalmente a região posterior de mandibula sendo muitas vezes assintomático e diagnosticado somente a partir de um achado imaginológico. Seu tratamento pode variar desde a descompressão cística seguida de enucleação com auxílio de técnicas complementares como a osteotomia periférica ate uma intervenção mais agressiva como a ressecção em bloco da região envolvida. Desde modo, em virtude do índice de recidiva e a gama de tratamentos existentes este trabalho tem como objetivo realizar uma revisão de literatura para analisar uma possível relação entre a porcentagem de recorrência e a escolha do tipo de tratamento. Para tal, foi realizada uma pesquisa bibliográfica tendo como base de dados PUBMED, SCIELO e MEDLINE. Foram incluídos os artigos que tenham o tema queratocisto odontogênico ou tumor odontogênico queratocístico e suas abordagens cirúrgicas de tratamento. de acordo com a classificação da Organização Mundial da Saúde. Os estudos concluíram que pode haver uma correlação entre o tratamento mais agressivo e o menor índice de recorrência da lesão.
THE FUNCTIONING OF HUMANITARIAN AID IN THE MALAGASY URBAN ENVIRONMENT TO ENSURE RESILIENCE TOWARDS SUSTAINABLE DEVELOPMENT
Authors:   Doctor in Management Sciences, Senior Lecturer, Faculty of Letters and Human Sciences, DYOGM Laboratory, University of Antananarivo, Madagascar., Andry Lova Herizo Rakotondramanana , Fanja Tiana Claudia Rakotomalala ,   Doctor in Management Sciences, Department of Management Sciences, University of Antananarivo, Madagascar., Mamy Alfa Randriamiharisoa ,   Senior Lecturer, / Doctor HDR Faculty of Economics, Management and Sociology, University of Antananarivo, Madagascar., Marc Tiana Andrianarizaka ,   Doctor in Cognitive Sciences and Applications, Faculty of Letters and Human Sciences, University of Antananarivo, Madagascar.
Published: January 2022

In Madagascar, faced with a galloping poverty rate, diseases, malnutrition, natural disasters, unemployment, illiteracy and illiteracy are hitting the population hard. In this context, social and economic aid aimed at an increasingly vulnerable population group is diversifying considerably. In general, humanitarians come to the aid of the most vulnerable to restore human dignity and alleviate the suffering of families in precarious situations. The question then becomes how will these humanitarian actions work to ensure resilience for socially sustainable development? This study, which aims to analyze the functioning of NGOs in the resolution of post-disaster socio-economic problems, allows us to affirm that taking into account the underlying factors: structural and situational, contributes to the achievement of the expected objectives for the strengthening of their resilience.
ETUDE DE LA CAPACITE DUNE PHOTOPILE AU SILICIUM A JONCTIONS VERTICALES SERIES SOUS ECLAIREMENT MONOCHROMATIQUE
Authors:   Polytechnic School of Thies, BP A10, Thies, Senegal., Yacine BA Mamadou , Faty MBAY FALL Mame ,   Polytechnic School of Thies, BP A10, Thies, Senegal., KABORE Mbi ,   Universite Nazi Boni (Unb), Bobo Dioulasso, Burkina Faso.,   Groupe International de Recherche en Energie Renouvelable(GIRER). BP. 15003, Dakar, Senegal., DIOP Gora ,   Polytechnic School of Thies, BP A10, Thies, Senegal., DIATTA Ibrahima ,   Groupe International de Recherche en Energie Renouvelable(GIRER). BP. 15003, Dakar, Senegal., SARR Mor ,   Groupe International de Recherche en Energie Renouvelable(GIRER). BP. 15003, Dakar, Senegal., SALL Mamadou ,   Polytechnic School of Thies, BP A10, Thies, Senegal., WADE Mamadou ,   Polytechnic School of Thies, BP A10, Thies, Senegal., SISSOKO Gregoire ,   Groupe International de Recherche en Energie Renouvelable(GIRER). BP. 15003, Dakar, Senegal.
Published: January 2022

Ce travail consiste a faire une etude de la capacite de la photopile a jonction verticale serie sous eclairement monochromatique en tenant compte de la longueur donde et de la profondeur. Lequation de continuite, traduisant, les phenomenes de generation, de diffusion et de recombinaison des porteurs de charge photogeneres dans la base de la photopile est resolue en tenant compte des vitesses de recombinaison a la jonction et en face arriere. Une etude de la capacite de diffusion en fonction des vitesses de recombinaison a la jonction base-emetteur mais aussi en fonction de la phototension a permis de determiner une capacite initiale Co, pour differentes longueurs donde de leclairement incident et pour differentes valeurs de la profondeur.
STUDY OF ANTIBIOTIC-RESISTANCE AND SENSITIVITY PATTERN IN A TERTIARY CARE TEACHING HOSPITAL
Authors:   Postgraduate, Associate Professor, Postgraduate., Parlapalli Sailajapriyadarsini , Padmavathy V.V ,   Associate professor, Siddhartha Medical College, Vijayawada., Rama Mohan Reddy Gunapati ,   Postgraduate, Associate Professor, Postgraduate.
Published: January 2022

Introduction: Antibiotics are helpful in bacterial infection control and management. Irrational antibiotic use leads to resistance, which puts modern medicines achievements at risk. This study aims to know antibiotic resistance and sensitivity patterns and to assess possible factors that favor the development of antibiotic resistance. Methods: It is a retrospective observational study. Data collected from June 2019 to May 2020 from the culture & sensitivity records of various clinical isolates at the Microbiology department of SMC, Vijayawada, and analyzed by descriptive statistics. Results: Total samples collected 2905. Only746 samples showed significant growth. Most commonly, isolated organisms were from Pus and Body fluids Staphylococcus aureus (31.16%), Klebsiella (23.02%), from blood samples Staphylococcus aureus (44%,) Klebsiella (32%), from urine samples Escherichia coli (27.31%),Staphylococcus aureus (16.66%). Bacteria isolated from, Blood and Pus & body fluid samples showed more resistance to Amoxicillin + Clavulanic acid, 60% &58.60%, and urine samples showed more resistance to Norfloxacin69.44%. Conclusion: In this study, bacteria isolated from, blood, pus, and body fluid samples showed more resistance to Amoxicillin + Clavulanic acid, from urine samples showed more resistance to Norfloxacin. Parenterally used drugs like aminoglycosides and vancomycin have retained their sensitivity but bacteria also showed resistance to Imipenem, Vancomycin, new combinations like Cefoperazone + Sulbactam. A culture & sensitivity test and following antibiotic stewardship guidelines before prescribing antibiotics will give good results to prevent antibiotic resistance.
ANTIOXIDANT PROPERTIES OF METHANOLIC EXTRACT OF BRYPHYLLUM PINNATUM ON ALBINO WISTAR RATS
Authors:   Department of Human Anatomy, Faculty of Basic Medical Sciences, College of Medicine and Health Sciences, Abia State University, Uturu, Nigeria., Chimaraoke Egeonu Solomon , Kelechi Uzoma Akataobi ,   Department of Medical Biochemistry, College of Medicine, Abia State University, Uturu., Ugorji Iheanacho Eke ,   Department of Medical Biochemistry, College of Medicine, Abia State University, Uturu.
Published: January 2022

Bryophyllumpinnatum, which belong to the family Crassulceae, is a succulent plant native to Madagascar, which is a popular houseplant and has become naturalized in tropical and subtropical areas. It has been in traditional medicine for the treatment of hypertension and kidney stones. Despite these acclaimed efficacies of its use in trado-medical practices, the effects on body organs are not well understood. The aim of this study was to evaluate antioxidant properties of Bryophyllumpinnatum. Fifteen adult Sprague dowley rats were use in this study split into three groups (group 1, 2 and 3). Group 1 animals served as the control, while group 2 and 3 served as the experimental groups. Acute toxicity, and antioxidants. The result of this study found LD50 to be above 5000mg/kg. In vitro antioxidant test found the presence of alkaloids, saponins, thiamin, riboflavin etc. Antioxidant activity test result found an increase in GSH, GPx, a decrease in MDA and a stable CAT. In conclusion, we recommend its uses in human, but at a regulated doses because of its efficacy as stated in this study.
EVALUACION DE RESULTADOSCLINICOS PARA CUADRICEPLASTIA PERCUTANEAENMILITARESEN EL ACTIVO CON DIAGNOSTICO DE RIGIDEZ ARTICULAR DE RODILLAEN EL ANO 2018, 2019 Y 2020 EN EL CENTRO MEDICO NAVAL
Authors:   Departamento De Traumatologia y Ortopedia, Centro Medico Naval, Ciudad De Mexico, 04470, Mexico., S. Escandon-Villafan , J. Gomez-Espindola ,   Departamento De Traumatologia y Ortopedia, Centro Medico Naval, Ciudad De Mexico, 04470, Mexico.
Published: January 2022

Statement of theproblem: Currentlyitis of utmostimportance to keep in mindone of themaincomplicationsorsequelaethatgeneratevariousjoint and periarticular conditionslocated in theknee and thatresult in decreased flexion and extensionmovements and isknown as jointstiffness, thereis a surgicaltherapeuticalternativecalledminimallyinvasivequadriceplastythat can restore flexion movementsthathavebeenalteredbythispathology. TheWorldHealthOrganizationemphasizesthatone of themostimportantstandards in thearea of traumatology and orthopedicshospitalizationisthe time ittakes to perform a surgicalprocedurefromthe time of diagnosis to theday of surgery. Knowingorknowingthissurgicaltechniquewouldfacilitate and reduce the time of choosingtheprocedure, sinceitwould be used in specificsituationssuch as, forexample: active militarywith a diagnosis of jointstiffness, alreadywithotherconditionstreated, and withlimitation to flexion and extension of thekneewithouthavingperformedanotherquadriceplastybefore. Objective: to determine theclinicaloutcome of percutaneousquadriceplastybyassessingthe pre- and post-surgicalrange of motion in patientswithkneejointstiffnesssecondary to peri- and intra-articular conditions. Methodology: Type of study: anobservational, cross-sectional, retrospectivestudywascarriedout. Population: 10 patientswith a diagnosis of kneejointstiffness, wherethe variables of age, sex, pre- and post-surgicalmobilityarches, physicaltherapy and rehabilitationsessions, orthopedicsurgicalhistory, and whethertheyhadanycomorbidityduringthestudywereanalyzedtaken. Results, Theaverage of thevaluesobtainedfromthearches of mobility in a pre-surgicalwaywas 38 compared to theresultobtainedfromtheaveragepostoperativewas 90 degreesobservedthattherewasanincrease in thearches of mobilityduringthepostoperative.
KNOWLEDGE AND AWARENESS OF INFORMED CONSENT AMONG DENTAL PATIENTS
Authors:   Research Scholar Prof & Head Department of Orthodontics RMDCH., Bhaskar V. , Rajasigamani K. ,   Research Guide Prof Department of Orthodontics RMDCH., Reddy Duvvuri S.N. ,   Associate Prof Department of Orthodontics RMDCH., R. Vinoddhine ,   Post Graduate Student Department of Orthodontics RMDCH., M. Shreeja ,   Post Graduate Student Department of Orthodontics RMDCH., R. Savitha ,   Post Graduate Student Department of Orthodontics RMDCH.
Published: January 2022

Obtaining informed consent from the patient is fundamental. The consent document should be in local language and should be simple and easy to understand. The awareness and knowledge on informed consent among both patients and the physician is essential in order to practice an efficient process as it is a continuous, two- way communication where transparency and partnership plays an important role.This study was undertaken to examine patients knowledge and awareness about informed consent process. 100 patients attending the Out Patient department were interviewed through questionnaire to assess the awareness and knowledge of the informed consent process. The present study revealed the percentage of patients who were aware of the informed consent process and the information provided in it.
A CONCEPTUAL STUDY ON ADAB OF THE LEARNED AND THE LEARNER IN ISLAM
Authors:   Faculty of Major Language Studies&Centre for Core Studies, Universiti Sains Islam Malaysia, 71800 Bandar Baru Nilai, Negeri Sembilan, Malaysia., Sulaiman Adibah , Zulfazdlee Abul Hassan Ashari Mohamad ,   Research Centre for Arabic Language and Islamic Civilization, Faculty of Islamic Studies, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia., Azraai Jamsari Ezad ,   Research Centre for Arabic Language and Islamic Civilization, Faculty of Islamic Studies, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia., Muhammad Imran Raja Abdul Aziz Raja ,   Kolej GENIUS@Pintar Negara, Universiti Kebangsaan Malaysia Kampus Seremban, IPG Raja Melewar, Jalan Sikamat, 70400 Seremban, Negeri Sembilan, Malaysia.
Published: January 2022

Distinguished Muslim scholars in the past and at present time have given a great emphasis on the importance of adab (Islamic ethics) in a believers life. Due to global ever-changing progress and development in terms of advanced technologies, almost all aspects of human beings life are considerably affected. In education, the teaching and learning process has evolved accordingly where users have, eagerly or unwillingly, accepted online learning as part of teaching and learning strategies. This situation has created worries among those who uphold the conventional Islamic corpus approach and those who support todays need in education. Therefore, the objective of this study is to examine the concept of adab of the learned and the learner from the viewpoint of Imam al-Nawawi to provide a fundamental guideline for the online learning educators and novices. A deductive textual approach is used to achieve the purpose. It can be concluded that the narrative of adab for the learned and the learner is undeniably apparent which may benefit users of online learning. It is suggested that a further study may analyze this subject matter in-depth to provide clear adab-based teaching and learning strategies for Muslim users in particular.
NEOLOGISM IN ENGLISH-ARABIC TRANSLATION OF INFORMATION TECHNOLOGY TERMS
Authors:   Research Centre for Arabic Language and Islamic Civilization, Faculty of Islamic Studies, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia., Azman Wan Mohammad Wan , Abu Bakar Kaseh ,   Research Centre for Arabic Language and Islamic Civilization, Faculty of Islamic Studies, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia., Zainal Hakim ,   Research Centre for Arabic Language and Islamic Civilization, Faculty of Islamic Studies, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia., Azraai Jamsari Ezad ,   Research Centre for Arabic Language and Islamic Civilization, Faculty of Islamic Studies, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia.
Published: January 2022

Technological advancements have aided in the expansion of a languages vocabulary through the addition of new items. Naming items can be accomplished during the translation process by constructing a diverse structure of neologisms. The purpose of this study was to analyse the results of technical term translations from English to Arabic in the field of Information Technology (IT) and to ascertain the frequency with which Arabic neologisms are published as a result of the process. Additionally, the study identified factors that influence the formation of neologisms through the translation process of translators. The study analysed data from the ProZ.com website regarding IT terms. The data were analysed by dividing the source term into a variety of neologism structures, such as derivatives, blended, compound, and acronym. The research was conducted using al-Sihabis theoretical framework for word formation, which classified word formation into two categories: Morphological Neologism, which refers to the process of word development, and Loan Neologism, which refers to the process of converting foreign language words to Arabic. The findings indicate that ProZ.com translators took one of two approaches to the formation of Arabic neologism: they either altered the original structure of the source term or preserved it as the structure of Arabic neologism. Nonetheless, 44% of the data wereconverted to compound form. While the majority of other neological structures are derived from the original structure of the source language. The structure of such neologisms is shaped by the translators translation process. Translators frequently translate data literally in order to preserve the source language neologism in its original form, according to studies. However, 25% of data were translated using descriptive and functional equivalence, while 13.1% of data were translated using the Arabization process, which converts source language terms that lack an Arabic equivalent.
EVALUATION OF THE VALIDITY OF HEMOCUE HB 201+ FOR PREDONATION ASSESSMENT OF LOW AND HIGH HAEMOGLOBIN LEVELS IN BLOOD DONORS: ONE YEAR PROSPECTIVE STUDY IN BLOOD BANK OF GMC DODA
Authors:   Medical Officer Department of Blood Transfusion Medicine., Mahvesh Sheikh , Gupta Nidhi ,   Assistant Professor Department of Pathology, GMC Doda., Bhagat Ritu ,   Assistant Professor Department of Pathology, GMC Doda.
Published: January 2022

Introduction: Predonation assessment of haemoglobin in blood donors is important to avoid unnecessary rejection of potential blood donors. Compared to the conventional screening methods for haemoglobin assessment the method to be used in blood banks needs to be rapid, sensitive and accurate for both low and high haemoglobin values. Materials and methods: This was a prospective study conducted in blood bank of GMC Doda w.e.f 1st April 2020 to 31st March 2021. Finger prick samples were taken from 1214 potential blood donors and hemoglobin was estimated using HemoCue Hb 201+. Also venous samples of potential blood donors were obtained and run on automated haematologyanalysers. The values were compared. Male donors with haemoglobin in the range of 12.5g/dl -18.5g/dl and females with hemoglobin in the range of 12.5g/dl -16.5g/dl were considered fit for donation. Results: We analyzed that haemoglobin levels measured by HemoCue Hb 201+ were higher than those measured by automated haematologyanalyser. We found a significant correlation between the standard method and HemoCue Hb 201+ for haemoglobin levels less than 12.5 g/dL. However the correlation was found to be less for high haemoglobin levels >18.5g/dl. Sixty percent of donors, who had haemoglobin levels higher than upper limit were unnecessarily rejected accounting for high deferral rate. Conclusion: We concluded that HemoCue Hb 201+ was suitable for screening for low haemoglobin in blood donors. Male predominance among blood donors and topography of this particular area accounts for donors with haemoglobin values near upper limit which were falsely deferred on the basis of HemoCue Hb 201+. Also testing with this method was found to be expensive, so it was recommended that qualitative methods should be used for primary screening among blood donors and accurate quantitative methods to be used only when qualitative methods fail.
FORMATION OF PROFESSIONAL COMMUNICATIVE COMPETENCE OF STUDENTS OF ECONOMIC SPECIALTIES (IN THE PROCESS OF LEARNING ENGLISH)
Authors:   Tashkent State University of Economics Islam Karimov 49 100066 Tashkent, Uzbekistan., Umida Tursunova
Published: January 2022

At present, the system of general and vocational education is undergoing fundamental changes, as never before, orient specialists towards creativity in their professional activities. The main goal of modern vocational education is to train a qualified, competent specialist who is ready to work in an increasingly competitive labor market. Modern professional activity imposes special requirements on the communicative training of specialists, which is manifested in the ability to negotiate, conduct a dialogue, correlate linguistic means with the tasks and conditions of learning, take into account social norms of behavior and the communicative expediency of statements.