bluuebunny/crossref_metadata_2025 huggingface dataset:
Una feromona de alarma produce reacción de congelamiento después de una sola exposición
Authors: Saldaña-Aguado Manuel , Gutiérrez-García Ana G. , Contreras Carlos M.
Published: December 2022

Los sistemas sensoriales permiten integrar estímulos y evocar respuestas ante situaciones de amenaza o peligro para favorecer la supervivencia. La 2-heptanona es una feromona de alarma identificada en varias especies y su acción se establece de inmediato, provocando reacciones de evitación y de huida. Dado que se desconoce su acción en el largo plazo, el objetivo de este estudio fue evaluar las conductas desplegadas por ratas macho (n= 24) en el laberinto de brazos elevados (LBE), en la prueba de enterramiento defensivo (ED) y en la prueba de campo abierto (CA). Usamos 3 grupos de ratas, un grupo fue expuesto a estimulación olfativa mediante un flujo de 1.5 l/min de aire impregnado con 3 µl de 2-heptanona. Otro grupo fue sometido a estrés mediante estímulos auditivos impredecibles (4 kHz, 75 dB). Un tercer grupo se empleó como control (sin estimulación sensorial). Las pruebas conductuales se realizaron 24 horas después de la estimulación sensorial. La exposición a 2-heptanona incrementó el tiempo de permanencia en brazos cerrados en el LBE (p<0.05) una reacción considerada ansiosa y el congelamiento en el ED (p<0.05), una respuesta adaptativa. No se encontraron diferencias en CA. La estimulación auditiva no produjo efectos conductuales observables 24h después de la exposición. En conclusión, la 2-heptanona permite la expresión de un comportamiento adaptativo para afrontar situaciones de amenaza, mediante el congelamiento lo que permite ser menos detectable por posibles predadores. La aportación, es que tal conducta ocurre aún 24h después de la exposición.
MicroRNAs and autism spectrum disorder: small tools for a complex disorder
Authors: Lara-Reyes Jesús Antonio , Llanes-Duran Alejandra , Aranda-Abreu Gonzalo Emiliano , Hernández-Aguilar María Elena , Rojas-Durán Fausto
Published: December 2022

El trastorno del espectro autista (TEA) abarca un grupo complejo de trastornos del desarrollo neural que se caracterizan por presentar deficiencias en la interacción social, la comunicación y motricidad del individuo. El TEA tiene un impacto en la salud pública, por lo que sería de gran utilidad contar con biomarcadores que permitan la identificación temprana del trastorno. En este sentido, los microRNAs (miRNAs), que son reguladores de una gran variedad de funciones celulares y cuyas alteraciones en su expresión han sido observadas en individuos con TEA, se comienzan a considerar como blancos potenciales para el desarrollo de estrategias de diagnóstico y terapéuticas para estos trastornos. Esta revisión se enfoca en algunos estudios sobre la participación de miRNAs en el TEA, en modelos animales y humanos, y hace una aproximación a su posible uso como biomarcadores.
Efectos de la avulsión unilateral de las raíces ventrales lumbosacras (L6-S2) sobre la conducta postural de la coneja: una propuesta de análisis
Authors: Castillo-Castillo Victor Manuel , Rodríguez-Alvarado Guadalupe Leonel , Bello-Zamora Miguel Angel , Corona-Quintanilla Dora Luz , Serrano-Meneses Martín Alejandro , López-García Kenia
Published: December 2022

El mantenimiento de la postura es una conducta motora fundamental de los mamíferos donde participan los sistemas nervioso y músculo esquelético. Un daño/alteración en la comunicación entre estos es capaz de modificarla. Se ha observado que lesiones directas o indirectas a nivel de médula espinal como la avulsión ventral lumbosacra (ARV) modifican la generación de patrones rítmicos formados por la actividad alternada entre un músculo flexor y un extensor (p. ej. locomoción y postura). Como objetivo de nuestra investigación buscamos evaluar el efecto de la avulsión unilateral derecha de las raíces ventrales lumbar 6 a sacro 2 (L6-S2) sobre la conducta postural de la coneja. Se utilizaron 12 conejas vírgenes (6 ± 2 meses de edad) divididas en dos grupos: 1) Sham (S) (n= 6), con simulación de la avulsión; y 2) Avulsionado (ARV L6-S2) (n= 6), con avulsión unilateral derecha a nivel lumbosacro (L6-S2). Quince días después de la cirugía se realizó el registro de la postura aplicando tinta en las huellas de las cuatro extremidades para ser registradas sobre papel doble carta. Las huellas fueron digitalizadas para medir las distancias y los ángulos entre ellas. La avulsión unilateral derecha L6-S2 afectó significativamente la conducta postural de la coneja mostrando diferencias significativas entre las distancias (p˂ 0.05) y los ángulos formados entre sus extremidades (p˂ 0.05). Nuestra conclusión es que la avulsión unilateral derecha L6-S2 en la coneja modifica su conducta postural y anula la locomoción debido al daño sobre la comunicación entre el sistema nervioso y el músculo esquelético.
La psicología clínica como disciplina de entrada y articuladora de las rutas en salud mental en Colombia
Authors: Delgado Reyes Andrés Camilo , Agudelo Hernández Andrés Felipe
Published: December 2022

Pese al aumento en los indicadores de depresión y otros problemas de salud mental, el abordaje de los problemas y trastornos afectivos sigue siendo deficiente, incluso cuando se cuenta con un marco legislativo nacional y con orientaciones basadas en la evidencia científica. Esto se ha relacionado con algunas dificultades del personal de psicología clínica para trabajar en el primer nivel de atención, por ejemplo, las rutas de atención en salud que no consideran esta disciplina como un paso inicial para ingresar al sistema de salud.
El objetivo de este artículo es señalar la importancia de la psicología clínica en el primer nivel de atención, más allá del logro de los resultados clínicos, en procesos de continuidad del cuidado en salud, de clima laboral y en términos económicos. Se exponen algunas cifras relacionadas con la depresión y su abordaje. Se proponen, finalmente, argumentos para incluir, desde el sistema de salud colombiano, la psicología clínica como una de las disciplinas articuladoras y puerta de entrada a la ruta de atención en salud mental.
Ficción de ficciones
Authors: Subirats Eduardo
Published: December 2022

Ensayo
La metáfora del viaje en Cantos y encantamiento de la lluvia, de Albalucía Ángel
Authors: Castrillón Carlos A.
Published: December 2022

El libro de poemas Cantos y encantamiento de la lluvia, de Albalucía Ángel, se presenta como la metáfora de un viaje de encuentros y desencuentros que tendrá un desarrollo complejo en Las Andariegas. En este artículo se propone una primera lectura de los indicios de esa metáfora, ligada al encantamiento de la palabra, el descubrimiento del erotismo personal y la reflexividad de la búsqueda.
Distribuição dos CAPS no estado da Paraíba, PB, Brasil: análise quantitativa
Authors: Oliveira Roberta Chagas , Medeiros Heydrich Lopes Virgulino
Published: December 2022

Introdução:Os Centros de Atenção Psicossocial são o principal componente da rede extra-hospitalar dentro da reforma da assistência em saúde mental. Formam um importante instrumento dentro do atendimento com base territorial e comunitária. Objetivos: realizar mapeamento e análise da distribuição dos Centros de Atenção Psicossocial e de suas equipes multiprofissionais no estado da Paraíba, a partir do enfoque da regionalização. Métodos: estudo descritivo, de recorte transversal, com abordagem quantitativa. Foram utilizados dados da Coordenação de Saúde Mental do estado da Paraíba, do Cadastro Nacional de Estabelecimentos de Saúde e Recursos Humanos. Foram calculados os índices de cobertura para as 16 regionais de saúde. As portarias 336/2002 e 130/2012 do Ministério da Saúde serviram de base para as análises referentes à quantidade de profissionais por serviço. Resultados: A Paraíba possui 113 Centros de Atenção Psicossocial distribuídos nas modalidades: I, II, III, ad, ad III e i. Observou-se que a 1ª região apresentou o menor índice de cobertura (1,03) e a 4ª região obteve o melhor resultado (5,74), ambas diferindo bastante do índice total do estado (2,12). Em relação às equipes multiprofissionais, observou-se que a quantidade de enfermeiros (201) e de outros profissionais de saúde (448) supre numericamente a quantidade de serviços, mas que o número de médicos (60) é bem inferior ao esperado. Vale destacar que 3 regionais não possuem nenhum psiquiatra registrado em seus quadros funcionais, com destaque para a 12ª região que aparece sem nenhum profissional médico apesar da existência de 4 serviços em seu território. Conclusões: A distribuição de CAPS na Paraíba é ampla e satisfatória, porém, com pouco quantitativo de médicos psiquiatras atuando nestes serviços.
Histological Changes of Liver and Lung Induced by Bisphenol a in Pregnant Mice
Authors: Al-Mustafa Sarab S , Al-Sultan Rayya G
Published: December 2022

The current study was conducted to investigate the tissue lesions induced by Bisphenol (BPA) in pregnant mice. The administration of BPA (450 mg/kg) begins from the seventh to the eighteenth day of pregnancy. The results showed behavioral changes that include increased activity and movement excessive, aggressive behavior and irritability for 15 minutes after the dose, sensitivity and itching in the ear area, and sleeping for several hours with decreased activity and loss of appetite, especially on the 17th and 18th days of pregnancy, bleeding and inflammation in the vaginal area was also observed on the 16th day of pregnancy. On the other hand, the results showed that the weights of pregnant mothers increased with the increase in BPA concentration compared to the control group. Histological changes in the fetus included congestion and swelling of sinusoids, necrosis, degeneration of hepatocytes, and infiltration of mono-nucleated cells. The lung showed destruction of bronchi, and thickening of inflamed cells. Alveolar walls were showed inflammatory cell infiltration and hemorrhage.
Evaluation of Antibacterial and Cytotoxicity Properties of Zinc Oxide Nanoparticles Synthesized by Precipitation Method against Methicillin-resistant Staphylococcus aureus
Authors: Rashid Ayat E. , Ahmed Mais E. , Hamid Mazin K.
Published: December 2022

A novel technique for nanoparticles with a chemical method and impact for resistance bacteria methicillin-resistant Staphylococcus aureus (MRSA), UV-visible analysis confirmed the by Fourier transform infrared spectroscopy (FT-IR) and Energy dispersive X-Ray (EDX), Scanning electron microscope (SEM) and X-ray diffraction pattern estimation antimicrobial excellent antibacterial activity against MRSA (with zone of inhibition of 11 ± 02 mm , 9 ± 01 mm,8 ± 03 mm and 7.5 ± 02 mm and 6.5 ± 02 mm) at different concentrations (0.5 ,0.25, 0.125, 0.0625, 0.03125) mg/ml while good activity was 16 ± 03 mm at 17 ± 02 mm zone at 0.25, 0.125 mg/mL, respectively. The increase in microorganism resistance to antibiotics a couple of have caused Antimicrobial factors are widely recognized (ZnO NPs) and are less toxic and biological safety . evaluation of MRSA by minimum inhibitory concentration (MIC) (0.5, 0.25, 0.125, 0.0625, 0.03125) mg/Ml of ZnO NPs. This research aims to study zinc oxide (ZnO) nanoparticles synthesis and antibacterial. In vivo evaluation precipitation method of cytotoxicity was determined WRL68 normal A375 cells.
Mouth Gargles and Antimicrobial Activities of Extracts of Corn Silk
Authors: Al-Janabi Ahmed S. , Khadim Oras M.
Published: December 2022

Carries and plaque of dental are the most widespread diseases, this problem are caused by the mixture of microorganisms and debris of food and are caused by a mixture of microorganisms and debris of food debris. Streptococcus mutans are the main culprit for dental problems that colonize on the dental surface and caused damage to the tooth surface. Corn silk alludes to the marks of shame of Zea mays L. (Gramineae) from the female blossoms of maize. it is restoratively utilized in the treatment various infection. Screening of plant against pathogenic microscopic organisms is a significant stage to approve its restorative properties. Subsequently, the point of this review was to research the capacity of extracted corn silk to inhibit the growth of cariogenic bacteria and compare the efficacy with commercial gargles and Amoxi-Clav antibiotics. Our in-vitro study results show a double inhibition effect on S. mutans as compared with amoxi-clav, and a significant inhibitory effect compared with commercial gargles. Corn silk extract were tested for their antimicrobial activity and showed higher significant activity than amoxi-clav and commercial gargle against S. mutans (p < 0.05)
Synthesis, Characterization and Bioactivity Study of Few Metal Complexes of Curcumin with 2-(1H-Benzimidazol-2-yl) Aniline
Authors: Rashid Khaled W. , Karem Lekaa K. A. , Rasheed Malath K.
Published: December 2022

We have synthesized many metal (II) complexes using curcumin L1 as the major ligand and 2-(1H-Benzimidazol-2-yl) aniline L2 as a supporting ligand. The complexes were characterized by spectroscopy methods such as; molar conductivity, elements microanalysis, Fourier-transform spectroscopy (FT-IR), UV-vis, and mass spectroscopy. Both curcumin ligands and L2 were found to be capable of binding to M(II) and metal ions via their two N atoms, according to the data. The formula for the complexes is the same. [M (L1)(L2)H2OCl], where M is Ni(II), Co(II), Cu(II), Cd(II), and Hg(II) (II). Octahedral complexes are proposed for the prepared compounds. The bio-actives suggested that the complexes are effective against bacteria and fungus on a mild to moderate level.
Comparison the Pathogenicity, Biofilm and Adhesion Activity of Acinetobacter baumannii Isolated from Patients using Thermoplastic Retainer with other Oral Isolates
Authors: Al-Khafaji Sarah A. , AL-Zreejaw Sarah Z. , Abed Saif M. , Kadhim Khalid H.
Published: December 2022

The study was focused on investigating the pathogenicity of Acinetobacter baumannii comparison with certain oral bacteria, Streptococcus mutans, Lactobacillus acidophilus, Streptococcus sangius, and Enterococcus faecalis associated with patients using a thermoplastic retainer by determination the response to Chlorhexidne (CHX), strength of biofilm formation and the adhesion ability. The results revealed that the isolation of bacteria reported by S. mutans was 95%, L. acidophilus 85%, S. sangius 75%, while A. baumannii and E. faecalis 65%. Moreover, the biofilm assay revealed various strengths of biofilm formation. The strong biofilm producer was A. baumannii, 0. 372 ± 009, the moderate biofilm producer was S. mutans, 0. 320 ± 012, the weak biofilm producers, L. Acidophilus 0. 195 ± 0. 10 S. sanguis 0. 170 ± 0. 00, and E. feacalis 0. 154 ± 0. 23 with significant differences between isolates at (p ≤ 0. 05). Furthermore, this current study found CHX was less effective against performed biofilm with various values, but the highest value was noticed in A. baumannii at 0. 125 ± 0. 03 comparison with other isolates, with significant differences at (p ≤ 0. 05). L. Acidophilus 0. 12 ± 0. 4, S. mutans 0. 102 ± 0. 12 S. sanguis 0. 113 ± 0. 5 and E. feacalis 0. 1 ± 00. Finally, The adhesion ability of isolates to the thermoplastic retainer during 30, 45, 60 minutes A. baumannii recorded the highest value during 30,45, and 60 minutes (220 ± 0. 09, 289 ± 0. 98 0. 87 ± 1. 1), respectively. Depending on the obtained results, A. baumannii played an important role in oral cavity infection especially in patients using thermoplastic retainers due to their resistance to CHX and their ability to form biofilm and adhesion to materials that are used to make thermoplastic retainers.
Anti-inflammatory Effects of Topically Applied Azilsartan in a Mouse Model of Imiquimod-induced Psoriasis
Authors: Mohammed Samer S. , Kadhim Haitham M. , AL-Sudani Israa M. , Musatafa Wael W.
Published: December 2022

Background: Many studies showed a possible exacerbation of psoriasis after exposure to angiotensin receptor antagonists. Azilsartan is a competitive angiotensin II receptor antagonist and has anti-inflammatory effects in various inflammatory disorders. Objective: Investigate dose-dependent effects of topical Azilsartan on Imiquimod-induced psoriasis in mice. Methods: Forty-eight mice are allocated into six groups (8 mice per group). They all received Imiquimod for the induction of psoriasis (except Group I, a negative control group). Group II (Induction group) received petroleum gel for six days after induction with Imiquimod. The other groups (III, IV, V, and VI) were given Clobetasol propionate 0.05, 1% Azilsartan, 3% Azilsartan, and a combination of 3% Azilsartan and 0.05% Clobetasol propionate ointments, respectively once daily for six days after induction. Results: Azilsartan decreased psoriasis area severity index (PASI) score and attenuated the histological manifestations after induction. It significantly decreased the serum and tissue levels of the inflammatory biomarkers (TNF-α, IL-17, IL-23, and NF-Kβ), especially when used as an add-on therapy to Clobetasol. Conclusion: Topically-applied Azilsartan shows anti-psoriatic effects in Imiquimod-induced psoriasis in mice via anti-inflammatory and anti-proliferative activities.
Experimental Design Statistically by Design Expert Software: A Model Poorly Soluble Drug with Dissolution Enhancement and Optimization
Authors: Challa Taraka R. , Reshma K. .
Published: December 2022

The experimental factorial design was performed design expert software to the formulation of rapid orally disintegrating tablets of a poorly soluble model drug to investigate by using superdisintegran.
Retinal nerve fiber layer thickness and its correlation with visual symptoms and radiological features in pituitary macroadenoma
Authors: Menon Sudha , Nair Soumya , Kodnani Anuj , Hegde Ajay , Nayak Raghavendra , Menon Girish
Published: December 2022

Objective:

The aim of the study was to evaluate the association of the thickness of retinal nerve fiber layer (RNFL) with (i) visual symptoms and (ii) suprasellar extension defined by magnetic resonance imaging (MRI) in patients with pituitary macroadenoma.

Materials and Methods:

RNFL thickness of 50 consecutive patients operated for pituitary macroadenoma between July 2019 and April 2021 were compared with standard visual examination findings and MRI measurements such as optic chiasm height, distance between the optic chiasm and adenoma, suprasellar extension, and chiasmal lift.

Results:

The study group included 100 eyes of 50 patients operated for pituitary adenomas with suprasellar extension. RNFL thinning predominantly involved the nasal (84.26 ± 16.43 μm) and temporal quadrants (70.72 ± 14.80 μm) and correlated well with the visual field deficit (P < 0.001). Patients with moderate-to-severe deficit in visual acuity had a mean RNFL thickness <85 μm and patients with severe disc pallor had extremely thin RNFLs (<70 μm). Suprasellar extension defined as Wilsons Grade C, D, and E and Fujimotos Grades 3 and 4 were significantly associated with thin RNFLs <85 μm (P < 0.01). Chiasmal lift more than 1 cm and tumor chiasm distance of <0.5 mm were associated with thin RNFL (P < 0.002).

Conclusion:

RNFL thinning correlates directly with the severity of visual deficits in patients with pituitary adenoma. Wilsons Grade D and E, Fujimoto Grade 3 and 4, chiasmal lift more than 1 cm, and chiasm tumor distance <0.5 mm are strong predictors of RNFL thinning and poor vision. Pituitary macro adenoma and other suprasellar tumors need to be excluded in patients with preserved vision but having obvious RNFL thinning.
Differences of physical literacy perception of kindergarten teachers: Seen from demographic information
Authors: Friskawati Gita Febria , Dwijantie Jeane Siti
Published: December 2022

Physical Literacy must be instilled in Early Childhood Education teachers have a very crucial role in this. The aim of this study is to reveal Early Childhood Education teachers' Physical Literacy perceptions in terms of demographic information. The survey research was conducted with a population of 74 teachers in West Java with convenience sampling. The Perceived Physical Literacy Instrument (PPLI) was used as an instrument to measure it. This instrument was distributed through a google form and filled out voluntarily by the participants. Analysis of the data used is descriptive analysis. The results of this study reveal that teachers with a younger age, teaching experience of 11-20 years, coming from Bachelor's graduates, and teaching in urban areas have a high perception of Physical Literacy compared to the demographic status of other teachers. There is a need for special education and training programs for Early Childhood Education teachers in designing learning scenes that are adapted to the concept of Physical Literacy and are able to harmonize it according to the level of growth and development of children, so that teachers can be formed from an early age. The unrepresentative sample in this study is a limitation that can be used as a recommendation for further research to reveal the perception of early childhood education teachers on physical literacy in Indonesia.
Need analysis of digital technology-based push up test: Instrument of arm muscle strength
Authors: Artanayasa I Wayan , Kusuma Ketut Chandra Adinata , Ariawan Ketut Udy
Published: December 2022

The rapid development of science and technology has an impact on the development of sports, both achievement sports, educational sports, and recreational sports. The use of technology and sport science is very important for the advancement of sports achievements. One of these implementations is the stage of testing and measuring physical conditions using instruments with a low level of human error. The purpose of this study was to analyze the need for the development of a digital technology-based push up test as an instrument for arm muscle strength. This research is a survey research that uses a quantitative descriptive approach. 256 respondents with a background as a lecturer at the Faculty of Sports and Health Undiksha, as well as athletes from Buleleng Regency, Badung Regency, Bangli Regency and Denpasar City filled out a questionnaire consisting of six statements. Questionnaires are used to determine the opinion of respondents on the needs of the developed instrument. Based on the results of the survey, the majority of respondents experienced difficulties in doing push up according to the procedure, and they stated that the manual push up test was prone to human error during calculations. Thus, all respondents agree with the development of digital technology-based arm muscle strength instruments. Referring to the results of the research above, this data can be one of the basic considerations in the development of a digital technology-based push up test which is intended in the process of measuring arm muscle strength with a good level of validity.
How is the mental toughness of student-athletes? An investigation of elite student-athletes in Bengkulu City
Authors: Pujianto Dian , Nopiyanto Yahya Eko , Kardi Ipa Sari
Published: December 2022

The objectives to be achieved in this study are knowing the level of the mental toughness of student-athletes in Bengkulu City. This research applies a quantitative descriptive method through a  causal-comparative design. The research population was 34 student-athletes from 5 sports. Determination of the sample using purposive random sampling. Data were collected using the Mental Toughness in Sport Questionnaire instrument. The data analysis technique uses standard deviation and the ideal mean to determine the level of the mental toughness of student-athletes, meanwhile to determine the level of the mental toughness of student-athletes who are reviewed based on sport and gender by hypothesis testing (one-way ANOVA and t-test) using SPSS. The results of data analysis found the category  of the mental toughness of student-athletes in Bengkulu City was very high and there were no differences in the mental toughness of athletes from each sport and gender. However, this study has not yet discussed the strategies and mental training programs implemented by athletes in each sport. Therefore, it is recommended that researchers who have an interest in continuing this research are advised to study further the strategies and programs of athletes' mental training.
PRACTICAL ASPECTS OF MATERIAL INVENTORY MANAGEMENT OF TRADING ENTERPRISES
Authors:   Odessa National Economic University, Karpenko Yuliia , Danylchak Anzhelika ,   Odessa National Economic University
Published: December 2022

The article considers the methodological bases of the inventory management process and the inventory distribution system of non- food and food retail enterprises of Ukraine. In particular, it was found that the inventory management process of the investigated enterprises is based on such models and methods as the model with a fixed period of time between orders, the principles of the theory of constraints; model of the economic size of the order, method of ABC analysis; a model with a fixed period of time between orders, a method of combined ABC and XYZ analysis. In addition, it was determined that enterprises use centralized and decentralized systems in the process of distributing stocks. As a result of the analysis, a number of advantages and disadvantages of the mentioned processes were highlighted. In particular, the key advantages of the inventory management process of trading enterprises include: taking into account the factor of seasonality and the location of stores; weekly tracking of store sales intensity; the possibility of taking into account the demand of each chain store; use of direct delivery services from suppliers, which allows to take into account perishable categories of goods; use of EDI electronic data exchange, etc. The main shortcomings include: untimely response of managers to possible unexpected circumstances of the external environment, which leads to an excess or shortage of goods in stores; unreasonableness of changes in the stock buffer when making decisions about the amount of material stock; insufficient validity of the calculation of the insurance reserve, lack of a clear distribution of the size of the insurance reserve by groups; the difficulty of promptly and fully resolving issues related to the purchase of goods, etc. Prospects for further research are the development of proposals for solving the identified problems, in particular, recommendations for optimizing the process of inventory management of trading enterprises.
THE ROLE OF COGNITIVE TECHNOLOGIES IN THE DIGITAL ECONOMY IN THE ASPECT OF BUSINESS ACTIVITIES
Authors:   Odesа Polytechnic National University, Yatskevych Inna , Stankevych Iryna ,   Odesa State Academy of Civil Engineering and Architecture, Sakun Hanna ,   Odesa State Academy of Civil Engineering and Architecture
Published: December 2022

The paper defines the role of the digital economy for the development of Ukraine and determines that the structure of the digital economy includes basic interconnected components: markets and areas of activity, platforms and technologies, and the environment. It is substantiated that one of the directions for implementing the digital development of the country is the formation of an appropriate cognitive-technological environment. It has been determined that cognitive technologies are a wide range of technologies for rationalizing and formalizing the functioning of intelligent systems for creating and building models of knowledge processing, communication and ensuring the reliability, validity and accuracy of managerial decision-making in an entrepreneurial ecosystem. It is substantiated that cognitive technologies are a tool for implementing cognitive methodology and a cognitive approach to the study of complex ecosystems in the business environment. The paper systematizes the features of the cognitive approach: the object of study, the entrepreneurial ecosystem, the researcher (observer). It is substantiated that the most effective cognitive approach is used in the study of bottlenecks and situations that include many elements and dependencies between them and are both quantitative and qualitative. The expediency of using cognitive technologies in solving bottleneck issues is determined. It is substantiated that the implementation of cognitive technologies in the control system is implemented through a software and hardware complex, which is a set of hardware and software tools that work together to perform one or more similar tasks. This software and hardware complex consists of data arrays (databases) and knowledge bases. The basis for the development and creation of a software and hardware complex is a set of economic and mathematical models of both tactical and strategic levels, which should become the organizational and technical basis for building a model of the digital economy as an economic cyber system, with the large-scale use of end-to-end technologies and platforms, which will effectively form relationships between the participants-partners of the entrepreneurial ecosystem.
CORPORATE CULTURE AS A KEY ELEMENT OF FORMING THE SOCIAL RESPONSIBILITY OF THE ORGANIZATION
Authors:   Kharkiv State Akademy of Culture, Ostropolska Zoia
Published: December 2022

The problems of the development of social responsibility in business due to the management of the corporate culture of the organization are considered; attention is paid to the importance, reasons and factors of the implementation of social responsibility in the modern business world; it is stated that when implementing social responsibility, organizations should act in two key directions: external communications (intended for an external audience, namely partners, consumers, influence groups, contractors, state authorities, etc. categories of society), internal communications (intended for the internal audience of the organization, namely the staff); emphasis is placed on the image components of the process of implementing social responsibility, namely the external and internal image of the organization; when studying the problem of implementing social responsibility, attention is focused on the formation of organizational culture as a key element of the organization's internal environment and the impact of corporate culture on the organization's development opportunities and its positioning as socially responsible; the key directions of formation of organizational culture, its functions and tools are defined; attention is paid to communication tools of organizational culture formation, namely intracompany information exchange (corporate newspaper, newsletters, codes of conduct, information portals, holidays, etc.); indirect methods (in-house training, trainings, certifications, interviews); methods of intergroup interaction (business games, group decision-making methods, mass events with presentations, public speeches, etc.); multimedia programs, corporate video (with the involvement of employees in the production); it is stated that communication tools are involved in the implementation of internal PR as a basic social technology in the formation of the organization's corporate culture; it was concluded that thanks to the formation of organizational culture, the company is able to use human potential to strengthen the reputation and image of the company and realize social direction and responsibility in full.
Education and training: qualification and competence
Authors: Соколова А.Ю.
Published: December 2022

В статье анализируются термины «компетенция» и «квалификация», обсуждается их применимость в рамках современных образовательных стандартов. Рассматриваются понятия «обучение» и «образование», которые составляют две взаимосвязанные стороны познавательной деятельности человека. Приводятся различия и сферы пересечения этих двух явлений и связи с понятиями «компетенция» и «квалификация». Провозглашенное всеобщее высшее образование привело к обесцениванию аттестатов и дипломов, прекращению равных возможностей профессионального продвижения, к отсутствию взаимосвязи между квалификацией и должностью. Модель компетенций пришла на смену модели квалификаций. Потребность в использовании новой терминологии была вызвана не столь внутренними противоречиями, сколько требованиями Болонского процесса общего понимания содержания квалификаций и степеней во всех образовательных стандартах стран - участниц. Действительно, понятие компетенции лежит в основе всех зарубежных образовательных стандартов.

The article analyzes the terms "competence" and "qualification", discusses their applicability within the framework of modern educational standards. The concepts of "training" and "education", which constitute two interrelated aspects of human cognitive activity, are considered. The differences and areas of intersection of these two phenomena and their connection with the concepts of "competence" and "qualification" are given. The proclaimed universal higher education has led to the depreciation of certificates and diplomas, the termination of equal opportunities for professional advancement, and the absence of a relationship between qualifications and positions. The competence model has replaced the qualifications model. The need to use the new terminology was caused not so much by internal contradictions as by the requirements of the Bologna Process for a common understanding of the content of qualifications and degrees in all educational standards of the participating countries. Indeed, the concept of competence underlies all foreign educational standards.
The effect of motivation on achieving job satisfaction through organizational justice - A field study on employees of the General Directorates of Education in the Sultanate of Oman –: أثر التحفيز على تحقيق الرضا الوظيفي من خلال العدالة التنظيمية - دراسة ميدانية على موظفي المديريات العامة للتربية والتعليم بسلطنة عُمان –
Authors: Fatma Hamed Mohammed Alnaimi, Nouna Sammari Fatma Hamed Mohammed Alnaimi, Nouna Sammari
Published: December 2022

The study aims at examining the validity of the influence of financial and moral motivation on job satisfaction through organizational justice as a mediator (an influential) variable of personnel at the general directorates of general education in the Sultanate of Oman, as well as investigating the nature of relations within the virtual model of the study, The researcher used a questionnaire as an instrument that was designed based on previous studies of each variable and was distributed to a random sample of (381) individuals from a population of (4137) individuals working in each of the education directorates in sultanate of Oman. The results of the study showed that there is a positive influence of financial and moral motivation on achieving job satisfaction, as the values of the standard evaluations showed that moral incentives will contribute (by 40%) in achieving job satisfaction and that financial incentives will contribute (by 60%) in achieving job satisfaction. The study also concluded that there are significant differences in the moral significance of the influential variable on the relationship between financial and moral motivation and job satisfaction in favor of the samples that support the organizational justice in the concerned public directorates.  The study recommends raising the level of job satisfaction of personnel by setting a system for incentives based on justice and objectivity and providing an environment that helps the staff feel positive towards the directorates.
The electrochemical response of electrode-attached redox oligo-nucleotides is governed by low activation energy electron transfer kinetics
Authors: Demaille Christophe , Clément Nicolas , Chovin Arnaud , Kim Soo Hyeon , Zheng Zhiyong
Published: December 2022

The mechanism responsible for electron transport within layers of redox DNA anchored to electrodes has been the subject of numerous studies over the last twenty years, but remains a controversial issue. Herein, we thoroughly study the electrochemical behavior of a series of short, model, ferrocene (Fc) end-labeled dT oligonucleotides, terminally attached to gold electrodes, using high scan rate cyclic voltammetry complemented by molecular dynamics simulations reproducing DNA Brownian motion. We evidence that the electrochemical response of both single-stranded and du-plexed oligonucleotides is controlled by the kinetics of electron transfer at the electrode, obeying Marcus theory, but with reorganization energies considerably lowered by the attachment of the ferrocene to the electrode via the flexible DNA chain. This so far unreported effect, that we attribute to a slower relaxation of water around Fc when attached to moving DNA, is shown to uniquely shape the time-dependent electrochemical response of Fc-DNA strands and, being markedly dissimilar for single-stranded and duplexed DNA, likely contributes to the signaling mechanism of E-DNA sensors.
New ionic liquids constructed on complexation of Aluminum chloride anhydrous and Chloroacetamide
Authors: Hasan Bassam , Salman Taghried
Published: December 2022

A new kind of ionic liquid was prepared by reacting chloroacetamide (CA) and AlCl3 at the best mole ratio (1:2) respectively. The resulting clear brown ionic liquid showed good heat stability at room temperature in a nitrogen gas-filled glove box, having an ionic conductivity of 0.34 mS/cm. FT-IR was used to establish its coordination. Other physical properties, such as viscosity and cyclic voltammetry have been measured.
Enantioselective diversification of alkene radical anions
Authors: Zhang Bin , Jiang Min , Zhang Zhi-Han , Zhao Ke , Qu Wen-Yuan , Xiao Wen-Jing , Chen Jia-Rong
Published: December 2022

Alkene radical ions constitute an integral and unique class of reactive intermediates for the synthesis of valuable compounds, because they have both unpaired spins and charge. However, relatively few synthetic applications of alkene radical anions have emerged, due to a dearth of generally applicable and mild radical anion generation approaches. Precise control over the chemo- and stereoselectivity in alkene radical anion-mediated processes represents another long-standing challenge due their high reactivity. To overcome these issues, here, we develop a new redox-neutral strategy that seamlessly merges photoredox and copper catalysis to enable the controlled generation of alkene radical anions and their orthogonal enantioselective diversification via distonic-like species. This new strategy enables highly regio-, chemo- and enantioselective hydrocyanation, deuterocyanation, and cyanocarboxylation of alkenes without stoichiometric reductants or oxidants under visible light irradiation. This work demonstrates the power of photochemistry in expanding new chemical space and overcoming persistent challenges in radical anion chemistry.
The Mechanism of Actions for Herbal Bioenhancers
Authors: Shenoy M Ashoka , Mahurkar Nitin
Published: December 2022

Herbal bioenhancers do not possess their own inherent pharmacological activity but when coadministered with other drugs enhances their bioavailability and thus the efficacy. The interest for bioenhancers arises because of the chemotherapeutic agents which are poorly bioavailable and administered for prolonged periods which can be toxic and expensive. One of the unique ways to achieve reduction in drug dosage and thereby drug toxicity and cost is to increase the bioavailability of drug. The present pharmaceutical research is more concerned with different aspects of exploring new chemical molecules having new modes of action. New drug development technologies were developed from the economics of treatment. There is a revolutionary shift in the way medicines are administered due to recent developments in enhancing the bioavailability. The present global focus is on methods aimed at reducing drug treatment period leading to decrease in drug treatment cost. The reduction in cost of therapy will make the treatment more affordable for the financially challenged sections of the society.nbspnbsp
Neem Gum as an Alternative to Synthetic Pharmaceutical Excipients
Authors: Kopparam Manjunath , Ravindrakullai Reddy M
Published: December 2022

Background Use of natural excipients benefits the national economy by delivering low-cost formulations and utilising locally available resources. The current study aimed to determine the ability of neem gum to serve as a binding and suspending agent as an alternative to synthetic excipients.Objective To prepare aceclofenac tablets and suspension by using locally available neem gum and to investigate the effect of neem gum on aceclofenac release from tablets and suspension.Methodology Aceclofenac tablets were prepared by wet granulation method containing mannitol as diluent using neem gum as a binding agent in concentrations of 2.5 5 7.5 and 10 ww and 7.5 ww of PVP as reference binding agent in the tablet formulation. In preparation of aceclofenac suspensions neem gum at concentrations of 0.5 1 1.5 and 2 wv were selected to function as suspending agent and the reference suspending agent used was 1.5 wv of sodium carboxymethylcellulose CMC.nbsp Results Investigation by the FT-IR spectroscopy and Differential scanning calorimetry DSC indicated that there were no chemical interactions between aceclofenac and neem gum. Prepared aceclofenac granules were evaluated and found satisfactory results for Carrrsquos index 9.14 -12.63 angle of repose 26.72 - 28.32deg and Haunserrsquos ratio 1.09 - 1.13. The corresponding tablets showed remarkable values for friability 0.45 - 0.86 disintegration time 243 - 321 sec and hardness 3.24 - 5.94 kgcm2. Aceclofenac suspension exhibited appropriate sedimentation volume 64 ndash 100 redispersibility 1 - 3 strokes pH 5.32 - 6.27 degree of flocculation 1.06 - 1.15.Conclusion As the concentration of neem gum in the formulation increased the rate of drug release slowed. Neem gum revealed a significant ability to bind granules in aceclofenac tablets at 10 ww and a good suspending capacity in aceclofenac suspension at 2 wv.
TREN, BIAYA, DAN TANTANGAN STRUCTURAL HEALTH MONITORING JEMBATAN
Authors: Pramudya Andreas A. , Wibowo Andreas , Soekiman Anton
Published: December 2022

Abstract

 

Information technology and the Internet of Things are developing rapidly, resulting in changes in all fields, including monitoring and testing bridges. Structural Health Monitoring (SHM) is currently an alternative to replace conventional visual inspections. This study aims to determine trends in the use of Structural Health Monitoring on bridges, including cost factors and challenges faced, so that they can be considered and referenced in the installation of Structural Health Monitoring on bridges in the future. This study uses biblio-metric analysis methods and literature review. Bibliometric analysis was carried out to determine the type of bridge, the method of Structural Health Monitoring, the type of sensor, and the part that the sensor was installed on, so that the trend of Structural Health Monitoring installation could be observed. A literature review was carried out on the challenges that occurred and the cost factors that were considered and their potential in the future. This research shows that the method of Structural Health Monitoring is still evolving and that new technologies have been used to overcome various challenges, including the cost factor. If Structural Health Monitoring can be mass produced, the cost of producing Structural Health Monitoring is expected to decrease.

 

Keywords: bridge; structural health monitoring; visual inspection; bibliometrics

 

 

Abstrak

 

Teknologi informasi dan Internet of Things berkembang dengan pesat, yang mengakibatkan terjadinya perubahan di segala bidang, termasuk pada pemantauan dan pengujian jembatan. Structural Health Monitoring (SHM) saat ini menjadi alternatif untuk menggantikan inspeksi visual yang bersifat konvensional. Penelitian ini bertujuan untuk mengetahui tren penggunaan Structural Health Monitoring pada jembatan, termasuk faktor biaya dan tantangan yang dihadapi, sehingga dapat menjadi pertimbangan dan acuan dalam pemasangan Structural Health Monitoring pada jembatan di masa mendatang. Studi ini menggunakan metode analisis bibliometrik dan tinjauan literatur. Analisis bibliometrik dilakukan untuk mengetahui jenis jembatan, metode Structural Health Monitoring, jenis sensor, dan bagian yang dipasang sensor, sehingga tren pemasangan Struc-tural Health Monitoring dapat diamati. Tinjauan literatur dilakukan pada tantangan yang terjadi dan faktor biaya yang menjadi pertimbangan serta potensinya di masa mendatang. Penelitian ini menunjukkan bahwa metode Structural Health Monitoring masih terus berkembang dan berbagai teknologi baru telah digunakan untuk mengatasi berbagai tantangan, termasuk faktor biaya. Jika Structural Health Monitoring dapat dipro-duksi secara massal, biaya produksi Structural Health Monitoring diharapkan menurun.

 

Kata-kata kunci: jembatan; structural health monitoring; inspeksi visual; bibliometrik
Chronicles - April, 2021
Authors: Tedjoworo Hadrianus
Published: December 2022

'Chronicles' is a journal column of "MELINTAS" which contains information about the various events, congresses, conferences, symposia, necrologies, publications, and periodicals in the fields of philosophy and theology.
From ‘Christification’ to Mission of Salvation: Impact of Damascus Event on Saint Paul
Authors: Hidayat Elvin Atmaja
Published: December 2022

Saint Paul is one of the most important apostles in Christianity. The mission of evangelism he carried out was fruitful in various parts of the world. Paul’s missionary journey brought great risks to himself through the challenges and the sufferings, while he was also previously known as a persecutor of Christ’s followers. His radical change or conversion occurred since his spiritual encounter with the Lord Jesus on his journey to Damascus. This article explores the impact of the unforgettable encounter that brings to Paul more admiration and love for Christ, that also brings an extraordinary mystical experience of ‘christification’, an experience of becoming more and more alike and united with the Christ. The Damascus event and the christification open the divine revelation of human salvation. As a Jew, Paul recognises that salvation is obtained by obeying the law, but now he believes that only the risen Jesus Christ is able to save humankind. Paul’s christification brings direct implications to his courage in becoming a follower of Christ with a burning passion to proclaim the Gospel to all nations. God’s choice for an apostle is unfathomable, even for Paul himself who considers himself as the most sinful and unworthy person.