bluuebunny/crossref_metadata_2025 huggingface dataset:
Economic and Lifestyle Factors Associated with the Vitamin D Deficiency among the Adult Population of Chandigarh
Authors: Dik Divesh
Published: May 2022

Background: Vitamin D deficiency is a matter of global concern. Various economic and lifestyle factors are associated with Vitamin D deficiency. However, the knowledge regarding the factors associated with Vitamin D deficiency is limited in consideration with the Chandigarh population, especially among adults. Aim and Objective: The present study aims at assessing the association of the Vitamin D deficiency with various economic and lifestyle factors among the adult population of Chandigarh. Materials and Methods: A cross-sectional study was conducted among 627 individuals of age group 30–70 years by adapting random sampling procedure. Economic and lifestyle particulars were collected using a detailed questionnaire. Vitamin D levels were analyzed using chemiluminescent immunoassay method. Results: The mean value of the Vitamin D level for the deficient, insufficient, and normal categories was reported to be 14.03 ± 3.41 ng/ml, 25 ± 3.16 ng/ml, and 36.96 ± 4.96 ng/ml, respectively. Vitamin D deficiency was significantly associated with occupation (P < 0.001), intake of multivitamin (P < 0.05), exposure to sunlight (P < 0.001), and type of food intake (P < 0.05). Conclusion: Working in closed environment, inadequate exposure to sunlight, lack of supplementation of multivitamin, and type of intake of food were possible factors significantly associated with the Vitamin D deficiency.
Epidemiological Study of Fluorosis on Different Age Groups in Tirunelveli District, Tamil Nadu, India
Authors: Suhirtha L. Gnana , Subramanian A.
Published: May 2022

The component fluorine has long been documented to have benefits for dental well-being. High doses have been linked to the development of dental fluorosis, skeletal fluorosis, and deformation of bones in children and adults. High fluoride concentrations are most often associated with groundwater as these accumulate fluoride from minerals sources. The use of this study was to determine the fluoride level of drinking water interrelated to different age groups of people nearby Radhapuram block, Tirunelveli district, Tamil Nadu, India. In the present study, 2500 samples were collected, analyzed, and performed to ascertain the prevalence of epidemiological fluorosis. Information on the total population 2500 in different age groups are recorded, among the normal people, 1273 (51.1%) were male and 1227 (48.9%) were female affected in Radhapuram block. Information on the total sample of 1183, 48.9% were male and 51.1% of females normal. Among the total number samples 328, 57.0% were male and 43.0% of females were questionable, 427 samples, 44.7% were male and 55.3% of females very mild, 228 samples, 45.2% were male and 54.8% of females mild, 262 samples, 47.3% were male and 52.7% of females moderate, and 72 samples, 59.7% were male and 40.3% of females were found severely affected. The persons belong to 11–20 years, 21–30 years, 31–40 years, 41–50 years, 51–60 years, and 60 above were normal (39, 52, 58, 50, 63, and 70%), questionable (18, 11, 9, 9, 5, and 0%), very mild (20, 18, 11, 17, 8, and 11%), mild (9, 8, 10, 9, 7, and 4%), moderate (10, 10, 9, 12, 13, and 15%), and severe (3, 2, 3, 3, 4, and 0%), respectively. The selected 2500 total population 2109 persons used tap water, 161 persons used mineral water, 147 persons used borewell water, and only 83 persons used municipal water for their drinking purpose.
Editorial
Authors: Hewitt Ramírez, Nohelia
Published: May 2022

Editorial Volumen 15 Número 2
Fractal dimensions of hydraulic parameters in sand mined alluvial channel
Authors: Barman Bandita , Barman Jyotirmoy , Kumar Bimlesh
Published: May 2022

Long-term extraction of sand from a river causes large mining pit on the river bed, and these pits change their fluvial processes. In this paper, an experimental study is executed to interpret the turbulence flow structure in a mining pit. This research mainly focuses on the fractal dimension of velocity fluctuations and Reynolds shear stress (RSS) of flow in the longitudinal and vertical plane for a mining pit region. The results show that the magnitude of fractal dimension for velocity fluctuation and RSS is smaller in the mining pit than the upstream and downstream of the pit. The large values of fractal dimensions at the pit downstream show an increase in flow roughness. It is found that the Taylor microscale decreases towards the channel bed, and this is because of increasing turbulence dissipation near the bed region. We have observed a significantly lower value of Taylor microscale in the mining pit. The higher value of the Taylor microscale is found far downstream of the pit. Nondimensional turbulence mixing length shows a decrease in the traversing length of an eddy at the far downstream of the pit.
Green Synthesis: A Land of Complex Nanostructures
Authors: Santo-Orihuela Pablo Luis , Catalano Paolo Nicolás , Desimone Martín Federico
Published: May 2022

The green synthesis of nanomaterials is nowadays gaining great attention owing to several
beneficial aspects in terms of the low toxicity of reagents and by-products, low damage to the
health and the environment, sustainability of energy savings and rational use of natural resources.
The intrinsic complexity offered by the biological sources (plants, microorganisms, animal products)
and the conditions applied in the synthetic procedures forms various nanomaterials with different
sizes, morphologies and surface properties that strongly determine their functionality and
applications. A deep understanding of the role of biological components, the mechanism of
nanostructure formation and growth, and the effects of green synthesis conditions is of paramount
importance to achieving the desired nanomaterial for the required application. In this context, this
review aims to provide an overview of the structural and functional complexity of nanomaterials
achieved by using green synthesis procedures, with a special focus on the role of biological sources
and parameters in controlling the complexity and benefit of nanomaterial applications.
Selection of Suitable Protein Structure from Protein Data Bank: An Important
Step in Structure-based Drug Design Studies
Authors: Yadav Mange Ram , Murumkar Prashant R. , Sharma Mayank Kumar , Gupta Pradeep , Patel Niyati M.
Published: May 2022

Selection of a protein structure is an important step for the success of the drug discovery process using structure-based design. Selection of the right crystal structure is a critical step as multiple crystal structures are available for the same protein in the protein data bank (PDB). In this communication, we have discussed a systematic approach for selecting the right type of protein structure. Some case studies for the selection of crystal structures of TACE, 11β-HSD1, DprE1 andSARS-CoV-2 Mpro enzymes have been discussed for the purpose of illustration.
Targeting of ErbB1, ErbB2, and their Dual Targeting Using Small Molecules
and Natural Peptides: Blocking EGFR Cell Signaling Pathways in
Cancer: A Mini-Review
Authors: Chandrasekar M.J.N. , Patnaik Sunil Kumar , Nagarjuna Palathoti , Ramamurthi Deepthi , Swaroop Akey Krishna
Published: May 2022

Cancer is one of the deadliest diseases involving dysregulated cell proliferation and has
been the leading cause of death worldwide. The chemotherapeutic drugs currently used for treating
cancer have serious drawbacks of non-specific toxicity and drug resistance. The four members
of the human epidermal growth factor receptor (EGFR), namely, ErbB1/HER1, ErbB2/HER2/neu,
ErbB3/HER3 and ErbB4/HER4, the trans-membrane family of tyrosine kinase receptors, are
overexpressed in many types of cancers. These receptors play an important role in cell proliferation,
differentiation, invasion, metastasis and angiogenesis and unregulated activation of cancer
cells. Overexpression of ErbB1 and ErbB2 occurs in several types of cancers and is associated
with a poor prognosis leading to resistance to ErbB1 directed therapies. Heterodimerization with
ErbB2/HER2 is a potent activator of Epidermal Growth Factor Receptor-Tyrosine kinase (EGFRTK)
complex than EGFR alone. Though ErbB3/HER3 can bind to a ligand, its kinase domain is
devoid of catalytic activity and hence relies on its partner (ErbB2/HER2) for initiation of signals,
thus, ErbB2 is involved in the activation of ErbB3. However, recent evidence reveals that ErbB1
and ErbB2 are the most important targets for cancer therapy. By inhibiting these two important
kinases, the cancer cell signaling transduction pathways can be inhibited. Lapatinib and monoclonal
antibodies like trastuzumab have been used for the dual inhibition of ErbB1 and ErbB2 in the
treatment of various cancers. Resistance, however, develops soon. The present report reviews the
investigations that have been carried out by earlier workers for targeting ErbB1, ErbB2, and both
using small molecules and novel peptides that could help/facilitate researchers to design and develop
better cancer chemotherapy.
One-Pot Synthesis of Novel Hydrazono-1,3-Thıazolıdın-4-One Derivatives
as Anti-HIV and Anti-Tubercular Agents: Synthesıs, Bıologıcal Evaluatıon,
Molecular Modelling and Admet Studıes
Authors: Mondal Sumanta , Pasha Mohammad Arif , Panigrahi Naresh , Shetye Gauri , Ma Rui , Franzblau Scott G. , Zheng Yong-Tang , Murugesan Sankaranarayanan
Published: May 2022

Background:

The necessity for newer anti-HIV and anti-tubercular medications has arisen as a
result of the prevalence of opportunistic infections caused by HIV (human immunodeficiency virus).

Objective:

A series of ten new hydrazono 1,3-thiazolidin-4-one derivatives were synthesized in one-pot
and evaluated for anti-HIV and anti-tubercular activities. Molecular Docking was accomplished with
HIV-1 reverse transcriptase protein (PDB ID: 1REV) and Mycobacterium Tuberculosis (M. tuberculosis)
H37Rv protein (PDB ID: 2YES) receptors along with drug-likeness and ADMET properties.

Methods:

One-pot synthesis of hydrazono 1,3-thiazolidin-4-one derivatives was carried out by ketones,
thiosemicarbazide and ethylchloroacetate with the catalyst of anhydrous sodium acetate. All
the synthesized compounds were characterized and evaluated for their in-vitro anti-HIV and also
evaluated for their in-vitro anti-tubercular activity against M. tuberculosis H37Rv. In-silico predicted
physicochemical parameters were done by MedChem DesignerTM software version 5.5 and ADMET
parameters by pkCSM online tool. Furthermore, molecular docking was performed with pyrx 0.8 by
autodock vina software.

Results:

All the synthesized compounds were characterized and evaluated for their in-vitro anti-
HIV activity for inhibition of syncytia formation, which shows KTE1 with EC50 47.95 μM and Selectivity
Index (SI) of >4.17 and for inhibition of p24 antigen production EC50 was found to be
80.02 μM and SI of >2.49. The compounds were also evaluated for their in-vitro anti-tubercular activity
against M. tuberculosis H37Rv, in which KTE1 MIC values of 12.5μg/ml with SI of >4.0 and
cytotoxicity against Vero cell lines. In-silico predicted physicochemical parameters for synthesized
compounds which were found to be drug-like. Furthermore, docking has shown a good dock score
and binding energy with anti-HIV and anti-tubercular receptors.

Conclusion:

From the novel synthesized molecules, none of the molecule is as effective as standards
for anti-HIV and anti-tubercular drugs and hence can be further explored for its potential activities.
Furthermore, derivatization was made to achieve more potent compounds for anti-HIV and
anti-tubercular drugs.
Assessing the Performance of GOLD, Glide and MM-GBSA on a Dataset
of Hydrazide-hydrazone-based Tuberculostatics
Authors: Mateev Emilio , Georgieva Maya , Zlatkov Alexander
Published: May 2022

Background:

Tuberculosis is considered a global health problem; hence, the screening and
synthesis of novel tuberculostatic drugs are a necessity. Molecular docking could drastically reduce the
time of hit identification; however, initial validation is required to reduce the false-positive results.

Objective:

Assessment of several searching and scoring algorithms for a custom dataset of hydrazidehydrazone-
based tuberculostatics was conducted to obtain a reliable docking protocol for future virtual
screening.

Methods:

Modification in the scoring functions, size of the grid space, and presence of active waters of a
GOLD 5.3 docking protocol was conducted. Subsequently, side-chain flexibility and ensemble docking
were carried out to assess the role of protein flexibility in the correlation coefficient. In addition, docking
simulations with Glide and free binding energy calculations with MM-GBSA were implemented. The
Pearson correlation coefficient between the experimental and the acquired in silico data was calculated
after each work step. The major interactions between the top-scored ligands and the active site of 2X22
were visualized applying Discovery Studio.

Results:

An optimized GOLD 5.3 docking protocol led to a drastically enhanced Pearson correlation coefficient
of the training set, from 0.461 to 0.823, as well as an excellent pairwise correlation coefficient in
the test set - 0,8405. Interestingly, the Glide docking scores and the free binding energy calculations with
MM-GBSA did not achieve reliable results. During the visualization of the top-ranked compounds, it was
observed that Lys165 played a major role in the formation of stable complexes.

Conclusion:

It could be concluded that the performance of the optimized GOLD 5.3 docking protocol
demonstrated significantly higher reliability against the hydrazide-hydrazone dataset when compared to
Glide docking simulations and MM-GBSA free binding energy calculations. The results could be utilized
for future virtual screenings.
Bacillus Calmette Guerin Injection Improves Hindlimb Motor Function
and Alleviates Inflammation through Upregulating Foxp3 Expression in
Rats with Spinal Cord Injury
Authors: Pu Xingwei , Wang Lihang , Luo Chunshan , Sun Guodong , Li Zhizhong
Published: May 2022

Background:

Immune and inflammatory reactions are important factors leading to secondary
spinal cord injury.

Aim:

This study aimed to investigate the effect of BCG on behavior after acute spinal cord injury in rats
and its related mechanisms.

Methods:

Rats with spinal cord injury were generated according to modified Allen’s method. Rats were
divided into the BCG group (rats with spinal cord injury intraperitoneally injecting with BCG), Model
group (rats with spinal cord injury intraperitoneally injecting with normal saline), and Sham group (normal
rats intraperitoneally injecting with normal saline). Basso, Beattie, and Bresnahan (BBB) scoring
system was used for evaluating behavioral outcomes. Foxp3 expression in spinal cord tissues was evaluated
using immunofluorescence analysis. HE staining was used for assessing the injury of spinal cord
tissues.

Results:

BBB scores of the Model group were remarkably lower compared to that of the Sham group
(P<0.05). Foxp3 expression was significantly downregulated in the Model group compared with that of
the Sham group (P<0.05). BBB scores of the BCG group were significantly higher compared to that of
the Model group at 3, 5, 7, and 14 days post-treatment (P<0.05). In the BCG group, there were fewer
inflammatory cells, smaller cavities, and a complete structural arrangement than in the Model group.
BCG treatment significantly reduced the spinal cord injury score compared to that of the Model group
(P<0.05). Post BCG treatment, Foxp3 expression was predominantly enhanced compared with that of the
Model group (P<0.05).

Conclusion:

BCG could affect inflammation after spinal cord injury through upregulating the expression
of Foxp3 and further promote the recovery of hindlimb motor function in rats with spinal cord injury.
In-silico Identification and Analysis of Hub Proteins for Designing Novel
First-line Anti-seizure Medications
Authors: Kumar Pawan , Sheokand Deepak , Saini Vandana , Kumar Ajit
Published: May 2022

Background:

Epilepsy is a seizure-related disease with different symptoms and types, depending
on the origin and propagation region of the brain. There are several marketed anti-seizure medications
(ASMs) available for choice of treatment by clinicians but there is a huge paucity of ideal first-line
ASMs.

Objective:

The present study was undertaken to identify and get an insight into the major target (hub)
proteins, which can be comprehensively used as a platform for designing first-line ASMs.

Method:

Large-scale text mining was done to generate a data warehouse of available ASMs and their
MOAs, followed by the identification of specific isoforms of target proteins for designing next-generation
ASMs, using network biology and other in-silico approaches.

Results:

The study resulted in the identification of 3 major classes of target proteins of major ASMs and
their specific isoforms, namely – GABA receptors (GABRA1, GABRB1, and GABARAP); VGSC (α-
subunitSCN2A (Nav1.2)) and VGCC (α-subunitCACNA1G (Cav3.1)). The identified proteins were also
observed to be concurrent with the target sites of majorly sold ASMs currently.

Conclusion:

The predicted hub protein families and their specific isoforms can be further validated and
comprehensively used to design next-generation novel first-line ASM(s).
Adjuvant Approach to Mitigate the Adverse Effects of Cancer Treatments
Using Homeopathic Medicines
Authors: Gupta Pankaj , Kumar Arun , Sharma Mahima , Prajapati Suneel
Published: May 2022

Background:

Worldwide, cancer patients are facing problems with life-and-death decisions due to the associated severe adverse and sometimes fatal effects of existing conventional
treatments. Due to the severe adverse effects of existing therapies, effective cures are progressively
explored for anticancer treatment. Mostly the conventional therapies are based upon nonspecific
cellular destruction properties; therefore, a treatment approach is desired to reduce the toxic burden
upon normal tissues. Among all alternative medicine systems, homeopathy is one of the most popular treatments for cancer patients globally due to its minimal side effects.

Methods:

In this present review, we have attempted to comprehend the literature reports on homeopathic medicine in cancer treatment.

Results:

Homeopathy has also proved its adjuvant approach to minimizing the symptomatic consequences of cancer. However, the insufficiency of evidence and lack of recurrence of the trials cause
difficulty in drawing any conclusion about homeopathy as adjuvant therapy. Based upon the etiology, the genoprotective potential of homeopathic drugs was reviewed and found inconsequential
evaluation and scanty literature

Conclusion:

Hence, the present review gives a comprehensive summary of retrospective studies and
suggests an integration of rational drug selection, standard protocols, and quantitative analysis for
revealing the differential role and plausible application of homeopathy in better cancer management.
Ethno-Medicinal Uses of Dongoria Kandha of Niyamgiri Hill, Odisha,
India
Authors: Das Sangeeta , Patnaik Swarnalata , Veni A. Leela
Published: May 2022

Background:

In the current study, the Ethnomedicinal data have been collected from tribal people of Niyamgiri hill region of Kalahandi district, Odisha, India. The tribals of this region have been using the medicinal plants to treat various diseases since the time immemorial.

Objective:

The main objective is to find out the mostly used plant parts and their Ethnomedicinal values used to cure different diseases by tribal people of Niyamgiri hill region of Kalahandi district, Odisha, India.

Methods:

It includes to record the information on medicinal uses of plant by leading healers by taking interviews and recording the comprehensive knowledge about the medicinal properties of different plants with the snow ball technique and sampling method. Plants are recognized by the local practitioner also known as Kabiraja or Vaidya in forest floor and were classified botanically.

Results:

The present study records the use of different parts of 50 plant species which belongs to 47 genera of 35 families, against 48 human diseases, with special reference to diarrhoea, dysentery, cold, cough, piles and fever. The practitioners use these plants to treat kinds of ailments like asthma, skin diseases, constipation, diabetes, toothache, wound healing, headache, infertility in women, mouth ulcer, insect bites, ring worms, thirst and eczema. All these medicinal plants are used as healing sources as there is not modern medical facilities available nearby. The collected data are analysed through use value (UV). Bacopa monnieri (UV of 1.50), Bryonia laciniosa (UV of 1.33), Andrographis paniculata (UV of 1.0), Bryophyllum pinnatum (UV of 0.83) and Celastrus paniculalus (UV of 0.83) are the most frequently and popularly used medicinal plant species in the study area.

Conclusion:

50 plant species that were collected from Niyamgiri hill region. It is found that still a large number of tribal people use their traditional knowledge and culture and have adopted herbal therapy for most of the diseases because of the strong belief of the local practitioners.
Stochastic Optimization Approach for Current Channel Arrangement of
LED Lights Fed by AC Direct LED Drivers
Authors: Asadpour-Ahmadchali Mohammad bagher , Enayati Javad , Yousefi Aliakbar
Published: May 2022

Background:

Because of significant challenges in locating conventional drivers into luminaires,
and also cost issues, a noticeable attitude toward AC direct LED drivers has been shaped. Nevertheless, the
multiplicity of target parameters like output lumen, efficacy in lumen per watt, power consumption, PF, THD,
and so on limits designers to select an optimal design of LED modules applying AC direct LED drivers.

Methods:

The most crucial issue in the design phase is selecting the Optimal Number of LEDs in Current
Channels (ONLCC) fed by the AC direct driver. The main contribution of the paper is utilizing an optimization
method based on a stochastic search to optimize the aforementioned parameters.

Results:

The parameters to be optimized are inserted into the predefined objective functions. Different case
studies conducted in the presented work show that the proposed method finds the optimal parameters while
the objective function is minimized. Such a paradigm can save time spent in the design phase. Furthermore,
a stability study is conducted to explore the stochastic search capability in solving the ONLCC problem.

Conclusion:

The obtained results from the simulation are supported by practical tests. All the validation
tests in practice are conducted in the electro-optics laboratory of the Mazinoor lighting industry.
Implementation of Barrier Sensing and Avoidance System on FPGA for a
Wheeled Robot
Authors: Pine Sandipan , Choudhury Bibhuti Bhusan
Published: May 2022

Aims:

This paper is to describe the process of spotting a barrier on the path of a wheeled robot and finding an alternate way to keep away from it.

Method:

For path, planning, image-processing technique is used and for this barrier-sensing and avoidance system, ultrasonic sensor is used. FPGA board processes the sensor output and after processing, it gives instruction to the motor arrangement to control the speed and direction of the wheeled robot.

Results:

We took one digital storage oscilloscope to collect all the data from sensor board. Although the color and lumen of the reflection matters a lot in the reading, so a variety of different objects we have selected to reduce the probability of error. A Very High Speed Integrated Circuit (VHSIC) Hardware Description Language (VHDL) block we generate for control algorithm and connect to the enable pin. Fig-8 shows the calculation block and fig-9 shows the ADC. As the FPGA board reads digital signal, hence the received signal we converted to digital with the help of an ADC of type NS ADC128S022. It is a 12-bit converter. Initially a bigger particle we kept in front of the sensor to understand and quantify the highest scope of it. DSO we used to view the response of both pulse and the analog signal. The code, which we have written for the operation of the ultrasonic sensor, has used a high logic of 10 µs width for triggering input. Program is measuring the object distance by calculating the logic high time of the ECHO pin that we have programmed as input. For servo operation, a pulse we used with 1.5ms on time and 20-millisecond time-period. To change the rotating angle different on time we have adopted.

Conclusion:

Wheeled robots have a no of applications. Depending on what sensor people use or what actuators or microprocessors they apply, the response time differs from one model to the other. To use it in real time applications a robot should give very fast response. In realistic approach FPGA development board is widely used in robot models recently because of its very fast response time, flexible system approach, quick generation of signals, parallel processing ability and obviously cost is pretty less when compared to other processor. References, figures, tables, chemical structures etc.
AI-Based Security Protocols for IoT Applications: A Critical Review
Authors: Chadha Harshita , Gupta Shruti , Khanna Ashish , Kumar Neeraj
Published: May 2022

The Internet Of Things (IoT) is a network of heterogeneous nodes that exchange data
and critical information amongst themselves with minimum human intervention. The utility of
this technology is large, thus it is used today in most modern applications. With billions of nodes
connected across multiple applications, the area for potential security attacks is ever increasing.
In addition to this, the nature of the data being transmitted also becomes more sensitive to the
latest applications and this calls for effective security provisions. Due to its unique nature,
traditional security provisions are not as successfully applicable in IoT networks. This leaves
these networks vulnerable to malicious intruders. In such a scenario, Artificial Intelligence (AI)
comes out as a powerful solution. This article serves to provide an overview of previously
proposed AI-based solutions that can be applied to IoT networks to secure them. An industrywide
overview of security provisions is provided by categorizing IoT applications into three
broad sectors, namely, healthcare, smart grid, and smart city. The survey strives to give a clear
industry-oriented vision of the available AI solutions and address the requirement of an
application-ready security survey in the field.
The Poetics of Mutilation in Apuleius’ Tale of Thelyphron (Met. 2,21-30)
Authors: Panayotakis Stelios , Papadimitriou Athanasios , Gemenetzi Eva
Published: May 2022

This paper discusses the episode of Thelyphron in the second book of Apuleius’ Metamorphoses and explores the significance of the recurring references to the bodily parts of the narrator/hero Thelyphron in the tale, pointing out their centrality, intertextual connections, and metaliterary function in the narrative. We argue that the processes of mutilation and prosthesis regarding the hero’s face correspond to the multifaceted literary character of the tale, and we discuss how the intertextual background of the above-mentioned physical change raises questions about literary composition and artistic creation.
Human Resistin as a Marker to Monitor Lupus Nephritis and Atherosclerotic Changes in Females with SLE
Authors: Ismael khaleel Sinan , Ghazzay Hazim , Faeq Hammad Ahmed
Published: May 2022

Systemic lupus erythematosus (SLE) is a polygenic chronic inflammatory condition that influences several body organs. While renal and dermatological changes are among the most common presentations of the disease. The current study examines the possible association between human Resistin (h-Res) and signs of disorder activities such as inflammation, renal function, lipids, and Bone Mineral Density (BMD) in females with SLE.

We performed cross-sectional research on 50 females with SLE diagnosed using the American College of Rheumatology (ACR) criteria. Forty females were recruited as controls. They matched the following items, including gender and body mass index (BMI) with age. In SLE patients, we discovered a statistically significant positive relationship between h-Res levels and ESR, CRP, Cr, ds-DNA, C3, duration of steroid treatment, and other variables. Disorder activity as determined by systemic lupus erythematosus disease index (SLEDAI) and carotid intima-media thickness (CIMT) (p-value <0.05). The levels of h-Res and C3 are discovered to have a statistically significant negative relationship. In the case of SLE, the h-Res level can be used as a marker for Lupus Nephritis (LN) and atherosclerosis. In patients of SLE, more aggressive therapy of the underlying inflammatory process and better control of the traditional risk factors may be beneficial in reducing the risk of renal and atherosclerotic derangement.

Keywords. biomarker, lupus nephritis, systemic lupus erythematous, Atherosclerosis
Whatever Happened to Liberation Theology? Demobilization of a Social Movement
Authors: Armet Stephen
Published: May 2022

This study uses Liberation Theology as a vehicle for understanding the demobilization of a religious social movement due to democratic consolidation. Building on social movement organizational literature, I analyze the case history of Departamento Ecuménico de Investigaciones in San José, Costa Rica in order to explain how a social movement remains effective in a competitive field of change organizations by becoming embedded in a representative organization that is able to mobilize its core constituency and maintain social influence. Macro organizational analysis is used to determine its position in the organizational field while organizational theory is used develop five characteristics of movement transformation that enable the organization to resist attrition and develop an enduring niche. Documentary and interview data of first and second generation Liberationists are used to provide an account of the structure and strategies that have enabled Liberation Theology to continue its influence in Latin America. I will argue that Liberation Theology has established a slow, protracted and unobtrusive strategy that has enabled the movement’s activists to extend their influence and establish a permanent niche in the socio-religious landscape of Latin America. This study contributes to the body of knowledge regarding social movement demobilization; particularly of a religious movement and contributes an update on the status of Liberation Theology in Latin America and the Caribbean.
RUSIJA NA BALKANU
Authors: Simeunovic Dragan
Published: May 2022

Prikaz knjige:

Slavenko, Terzić. 2021. Na kapijama Konstantinopolja. Rusija i balkansko pitanje u 19. veku. Beograd: Istorijski institut. Novi Sad: Pravoslavna reč, 742 str.
„DVOJNIK DRŽAVE” U KULTURNOJ POLITICI SRBIJE (1971-2021)
Authors: Djukic Vesna
Published: May 2022

Predmet rada je model „Dvojnik državeˮ koji je u kulturnoj politici Srbije razvijala disidentska intelektualna elita izražavajući neslaganje sa vladajućim političkim i kulturnim tokovima. Cilj rada je da se utvrdi korelacija između ovog nezvaničnog modela i zvaničnih modela kulturnih politika. Istraživanje obuhvata analizu paradržavnog modela „samoupravljanja u kulturi” Socijalističke Federativne Republike Jugoslavije (SFRJ) i državnog modela „blokirane tranzicije” sa varijacijama u periodu Savezne Republike Jugoslavije (SRJ) i Republike Srbije (RS).
Za potrebe teorijskog istraživanja primenjen je metod istorijsko-koparativne analize modela odlučivanja o kulturi u periodu 1971-2021. Period od 50 godina je posmatran kroz četiri vremenske tačke preseka koje predstavljaju prelomne trenutke daljeg razvoja kulturnih politika u Srbiji: sedamdesete (Kongres kulturne akcije 1971. i uvođenje samoupravljanja u kulturi 1974) i devedesete godine 20. veka (Osnivanje fondova za finansiranje kulture i ukidanje samoupravljanja u kulturi 1990), desete (donošenje Zakona o kulturi 2009. i izbori 2012) i dvadesete godine 21.veka (ponovno otvaranje muzeja i donošenje prvog strateškog dokumenta o prioritetima razvoja kulture Vlade RS (2021).
Empirijski podaci koji se odnose na period 2012-2021. prikupljeni sa zvaničnih internet prezentacija Ministarstva kulture i informisanja Republike Srbije, Službenog glasnika Republike Srbije, Fondacije 2022. Novi sad Evropska prestonica kulture, Portala za kulturu jugoistočne Evrope “SEE cult”, nevladine organizacije Balkanska istraživačka mreža „BIRN Srbija” i online izdanja medija (BBC news – na srpskom, Blic, VREME, Danas, Dnevnik, Peščanik, Politika, Slobodna Evropa, Nova S, Novi plamen BiH, Novosti), kontekstualizovani su primenom metode medijske arheologije.
Rezultati istraživanja su pokazali da uprkos teorijskim razlikama između modela kulturnih politika, u praksi odlučujuću ulogu na donošenje strateških odluka o kulturnom razvoju ima simbioza birokratije u javnoj administraciji i mreže političkih partija, civilnih organizacija, medija i intelektualne, kulturne i umetničke elite koja deluje u okviru „disidentskog potkulturnog modela”. Tako je u oblasti kulture stvoren treći model koji smo nazvali „dvojnik države”. Budući da sputava i ograničava umesto da podstiče kulturni razvoj, ne može se nazvati istinskom kulturnom politikom već pseudokulturnom politikom koja je prema pravcu delovanja restriktivna, a ne podsticajna, što je samo korak od antikulturne politike.
THE FATE OF TWO REVOLUTIONARY PROPHECIES: MARY WOLLSTONECRAFT AND WILLIAM BLAKE ON EDMUND BURKE
Authors: Peto Zoltan
Published: May 2022

In my paper, I would like to investigate two forms of criticism directed towards one of the most famous texts of the “founding father” of conservatism, Edmund Burke’s Reflections on the Revolution in France. The one is a critique by an adherent of radical enlightenment, the “proto-feminist Mary Wollstonecraft who sees the French “Ancién Regime” and the British system of government of the time both in a negative context and would like to replace them with strict political rationality and “pure reason.” The other critique, William Blake sees the French Revolution not as an act of political rationalism but as a spiritual renewal and interprets it not as a tabula rasa but as a return from an already too rationalist to a free and just state of existence. I investigate Wollstonecraft’s essay Vindication of the Rights of Men and Blake’s poem The French Revolution. In conclusion, I try to find the answer why the two aforementioned authors, (as the majority of Burke’s initial critics) lost their enthusiasm about the revolution, within the context of the Jacobin dictatorship and the birth of anti-revolutionary political conservatism defended and justified by Burke.
Partidos vecinales: introducción a denominaciones y características regionales en Argentina
Authors: Tonon María Cecilia
Published: May 2022

Este artículo es una aproximación al estudio de los partidos vecinales durante la transición democrática en Argentina, particularmente en el Departamento Castellanos del Centro-Oeste de la provincia de Santa Fe. La propuesta se focaliza en indagar las posibles denominaciones de estas organizaciones, para poder definirlas y caracterizarlas. Para ello, combina tres ejes de análisis: el de las perspectivas disciplinares (centradas en las contribuciones de la ciencia políti-ca, la sociología y la historia política), el de los aspectos jurídicos y el de los aportes empíricos
Análisis de la implementación en la política pública pesquera en México (LGPAS)
Authors: Suasnávar Imán Mariana , Fitzmaurice Cahluni Fernanda , Fernández-Rivera Melo Francisco J. , Espinosa Romero María José
Published: May 2022

La sobreexplotación de los recursos marinos conduce a la escasez de éstos, dejando como principales actores vulnerables a las comunidades costeras en términos de seguridad alimen-taria y social. En México, uno de los modos de atención a estas problemáticas ha sido a través de la generación de cambios en la gobernanza de los recursos mediante las políticas públicas. La Ley General de Pesca y Acuacultura Sustentable (LGPAS) regula la actividad pesquera y acuícola en el país por medio de 152 artículos, describiendo las facultades y obligaciones del Estado, así como los principales actores involucrados y propone fundar sus acciones a través de herramientas internacionales
Library Management System
Authors: Sharma Sourabh , Mishra Sunny , Gupta Shubham , Kumar Sachin
Published: May 2022

Abstract: A Library Management System is a project that tries to create an automated and computerised version for a library so that the daily work of a library can be managed and monitored easily and efficiently. Earlier, the librarian used to manage the whole work in manual mode in the form of files and record books. Also, the process of adding new books, new students, issuing and returning books had to be managed in a manual manner which is very slow and inefficient. The library management system resolves this problem and provide a better solution to this. It provides a user-friendly interface application to the librarian where he can do all the operations of a library very easily. The application mainly consists of three modules which are admin module, librarian module and student module. The admin module will be managed by the system administrator. He manages the overall functioning of the application. The librarian module will be accessed by the librarian. He can perform various operations inside the application such as add new students, new books to the database, issuing and returning of books, updating student’s details, book’s details, generating weekly/monthly reports etc. The student module can be accessed by the registered students only. The operations that can be performed by the student includes: view all books available in the library, search the availability of a particular book, number of books he has issued, overall fine he has to pay etc. These three modules are interconnected with each other and also with the database. The application is built using Java technology and Sql database. Keywords: Library Management System, Module, Java, Sql, Database
Taxi Demand Forecasting Utilizing Neighbourhood Influence Based on Ensemble Learning
Authors: Thakur Apoorva , Monga Dr. Sandeep
Published: May 2022

Abstract: This Time series forecasting (TSF) assists in making better strategic decisions under uncertain circumstances so that financial crisis can be avoided, wise investments can be made, under/over contracting of utility can be avoided, staffs can be scheduled appropriately, service providers can provide better service, mankind can get prepared for natural disasters and many more. However, the accuracy in forecasting plays a vital role and achieving such is a challenging task owing to the vagueness and nonlinearity associated with most of the real world time series. Therefore, improving the forecasting accuracy has become a keen area of interest among the forecasters from different domains of science and engineering. In this work, a time series forecasting model for Chicgo taxi trip data is proposed. The proposed model utilizes neighbourhood influence in terms of taxi demand to predict taxi demand. Keywords: Time series forecasting, Regularization, Regression
Desktop Voice Assistant
Authors: Gupta Ujjwal , Jindal Utkarsh , Goel Apurv , Malik Vaishali
Published: May 2022

Abstract: The primary goal of trending technology artificial intelligence (AI) is to realize natural human-machine dialogue. Various IT-based companies also utilized dialogue networks technology to create various types of Virtual Personal Assistants focused on their products and areas for expanding human-machine contact, such as Alexa, Cortana, Google's Assistant, Siri and so more. Just like the Microsoft voice assistant named 'Cortana', we designed our virtual assistant which performs basic tasks based on the instruction provided to it on the Windows platform using Python. Here, Python is used as a scripting language as it has a large library that is used to perform instructions. Using Python packages, a personalized virtual assistant recognizes and processes the user's voice. Voice assistants are a fantastic advancement in the sector of Artificial Intelligence that can transform people's lives in a variety of ways. The voice-based assistant was initially given on cellphones and quickly gained popularity. It was widely acknowledged by all. Previously, voice assistants were largely found in smartphones and laptops, but they are now increasingly available in various home automation setups and smart speakers. Many technologies seem to become wiser in their very own way, allowing them to converse with humans in a simple language. Desktop voice assistants are programme that can identify people's speech and answer through an integrated speech system. This paper will outline how different voice assistants work, as well as their primary challenges and limitations. The way of developing a voice-based assistant without requiring cloud services is discussed in this paper, which would promote the future growth of such devices. Keywords: Voice Assistant, Speech Recognition, Python, Smtplib, Automation.
TINDAK TUTUR DIREKTIF DAN IMPLIKATUR KONVENSIONAL DALAM WACANA MEME DILAN
Authors: Achsani Ferdian
Published: May 2022

Meme merupakan salah satu wacana yang paling baru, yang akhir-akhir ini sering dijumpai di media social. Kehadiran meme digunakan oleh penutur sebagai sarana untuk mengekspresikan diri melalui bahasa humor dan disertai gambar yang mendukung. Penelitian ini bertujuan untuk mendeskripsikan implikatur atau makna yang terkandung dalam meme Dilan. penelitian diskriptif kualitatif, dengan teknik pengumpulan dokumen dan teknik analisis interaktif ini menyimpulkan bahwa beberapa wacana meme dilan mengandung tindak tutur direktif dan memiliki makna yang variatif sesuai dengan konteks wacana meme sendiri. Beberaapa tindak tutur yang terdapat dalam wacana meme dilan seperti memerintah, menyarankan, menuntut dan memberi nasihat. Sedangkan makna implikatur yang terdapat dalam wacana meme dilan seperti, mematuhi peraturan, membantu orang tua, beribadah, iklan, sindiran dll. Melalui hasil dari penelitian ini dapat digunakan guru sebagai media pembelajaran pada materi teks iklan, slogan, poster pada kelas VIII. Hal ini dikarenakan melalui sebuah meme, maka akan membantu siswa dalam mengembangkan bahasa, gagasan atau opini siswa, sehingga dapat digunakan sebagai media pembelajaran.
Pemetaan Penguasaan Kosakata Budaya Dasar Penutur Jati Bahasa Kafoa sebagai Wahana Pemelajaran Bahasa Daerah
Authors: Zabadi Fairul
Published: May 2022

Abstrak

Penelitian ini bertujuan untuk memetakan penguasaan kosakata budaya dasar bahasa Kafoa di Nusa Tenggara Timur oleh penutur jati agar dapat dimanfaatkan sebagai wahana pemelajaran bahasa daerah. Metode yang digunakan adalah kualitatif deskriptif melalui teknik kuisioner dan tanya jawab. Data penelitian berupa jawaban informan terhadap kuisoner yang sudah disiapkan dan tanya jawab langsung. Data tersebut bersumber penutur jati bahasa Kafoa yang terdiri atas penutur berusia di atas 25 tahan dan di bawah 25 tahan yang berasal dari Desa Probur Utara. Hasil penelitian memperlihatkan bahwa berdasarkan  446 kosakata badaya dari sembilan ranah yang ditanyakan, kosakata kata yang dikuasai berjumlah 376 (84,30%) dan yang tidak dikuasai berjumlah 70 kosakata (15,70%). Kosakata yang tidak dikuasai tersebut sersebar pada kedua kelompok penutur jati, yaitu penutur di atas 25 tahun sebanyak 21 kosakata (30%) dan penutur di bawah 25 tahun sebanyak 49 kosakata (70%). Sementara itu, kosakata yang tidak dikuasai oleh penutur di bawah 25 tahun, tapi dikuasai penutur di atas 25 tahun berjumlah 28 kosakata (40%). Oleha karena itu, kosakata budaya yang tidak dikuasai penutur jati tersebut menjadi prioritas dalam pembelajaran bahasa daerah di Kabupaten Alor, NTT, sehingga vitalitasnya dapat terus terjaga.

Kata kunci: Pemetaan; Kosakata Budaya; Penutur Jati: Kepunahan.

Abstract

This study aims to map the mastery of basic cultural vocabulary of the Kafoa language in East Nusa Tenggara by native speakers so that it can be used as a vehicle for learning local languages. The method used is descriptive qualitative through questionnaire technique. The research data are  informants' answers to the prepared questionnaires and direct questions and answers. The data is sourced from native speakers of the Kafoa language, consisting of speakers aged over 25 and under 25 from North Probur Village. The results showed that based on 446 basic cultural vocabularies from the nine domains asked, the vocabulary mastered was 376 (84.30%) and 70 vocabularies were not mastered (15.70%). The vocabularies that are not mastered are spread over the two groups of native speakers, namely speakers over 25 years old with 21 vocabularies (30%) and speakers under 25 years old with 49 vocabularies (70%). Meanwhile, the vocabulary that is not mastered by speakers under 25 years old, but mastered by speakers over 25 years is 28 vocabularies (40%). Therefore, the cultural vocabulary that is not mastered by native speakers becomes a priority in learning local languages ​​in Alor Regency, NTT, so that its vitality can be maintained.

Keywords: Mapping; Cultural Vocabulary; Native speakers; Extinction.
Moral Lingkungan Alam pada Dongeng dari Yunani The Peasant And The Apple Tree Melalui Pendekatan Ekokritik
Authors: Amalia Nur , Nawawi
Published: May 2022

Salah satu aspek moral yang perlu diperkenalkan pada anak usia dini adalah sikap moral terhadap lingkungan yang dideskripsikan sebagai sebuah evolusi alamiah dalam dunia. Penelitian ini bertujuan untuk memberikan kritik ekologi dalam dongeng Yunani The Peasant and The Apple Tree melalui pendekatan ekokritik. Metode penelitian yang digunakan dalam penelitian ini metode deskriptif kualitatif, sedangkan pendekatan yang digunakan untuk menganilisa data adalah pendekatan ekokritik. Teknik Analisis data yang digunakan adalah analisis isi. Hasil analisa dan pembehasan menunjukkan bahwa manusia adalah bagian dari lingkungan oleh karena itu manusia harus mengerti moral linkungan hidup dan harus mempunyai kesadaran akan pentingnya kesadaran ekologi, manusia harus mencintai lingkungan alam. Moral lingkungan hidup yang harus dipahami dan ditanamkan pada anak-anak adalah lingkungan yang berkaitan dengan kesadaran akan pentingnya menjaga kebersihan lingkungan,  refleksi masyarakat tentang lingkungan alam, mencintai kearifan alam ekologi, dengan  pemberian hak hidup bagi mahluk hidup lainnya, penghormatan pada alam,  pada makhluk kecil dan tidak berdaya dengan menggunakan unsur alam, adanya mekanisme pengendalian perilaku masyarakat agar menghormati mahluk ekologis lainnya, dan menciptakan sistem pertanian yang sesuai dengan lingkungan