bluuebunny/crossref_metadata_2025 huggingface dataset:
No Sex Differences in the Attentional Bias for the Right Side of Human Bodies
Authors: Lucafò Chiara , Marzoli Daniele , Ferrara Cosimo , Bertollo Maurizio , Tommasi Luca
Published: February 2023

Ambiguous silhouettes representing human individuals which perform unimanual actions are interpreted more often as right-handed. Such a preference might reflect a perceptual frequency effect, due to the fact that most social interactions occur with right-handers. As a consequence, observers would preferentially attend to the region in which others’ dominant hand usually falls, thus increasing the efficiency in monitoring both aggressive and communicative acts. Given that men can be more dangerous compared with women, the right-hand bias should be larger when observing male rather than female individuals, and given that aggressive interactions involve men more frequently than women, it should be larger in male rather than female observers. However, previous studies did not specifically test whether: (i) male—compared with female—observers pay more attention to the right side of others (regardless of the observed individuals’ sex), or (ii) observers (regardless of their sex) pay more attention to the right side of male—compared with female—individuals. Therefore, in the present study we used ambiguous human silhouettes rotating about their vertical axis with one arm extended in order to determine whether the rightward bias is larger for male rather than female figures and/or in male rather than female participants. According to our data, the bias toward the right side of human bodies was not significantly associated with either the figure’s or the participant’s sex.
Modelling and Analysis of a Measles Epidemic Model with the Constant Proportional Caputo Operator
Authors: Farman Muhammad , Shehzad Aamir , Akgül Ali , Baleanu Dumitru , Sen Manuel De la
Published: February 2023

Despite the existence of a secure and reliable immunization, measles, also known as rubeola, continues to be a leading cause of fatalities globally, especially in underdeveloped nations. For investigation and observation of the dynamical transmission of the disease with the influence of vaccination, we proposed a novel fractional order measles model with a constant proportional (CP) Caputo operator. We analysed the proposed model’s positivity, boundedness, well-posedness, and biological viability. Reproductive and strength numbers were also verified to examine how the illness dynamically behaves in society. For local and global stability analysis, we introduced the Lyapunov function with first and second derivatives. In order to evaluate the fractional integral operator, we used different techniques to invert the PC and CPC operators. We also used our suggested model’s fractional differential equations to derive the eigenfunctions of the CPC operator. There is a detailed discussion of additional analysis on the CPC and Hilfer generalised proportional operators. Employing the Laplace with the Adomian decomposition technique, we simulated a system of fractional differential equations numerically. Finally, numerical results and simulations were derived with the proposed measles model. The intricate and vital study of systems with symmetry is one of the many applications of contemporary fractional mathematical control. A strong tool that makes it possible to create numerical answers to a given fractional differential equation methodically is symmetry analysis. It is discovered that the proposed fractional order model provides a more realistic way of understanding the dynamics of a measles epidemic.
Relating Fluctuating Asymmetries and Mean Values and Discordances of Asymmetries in a Set of Morphological Traits
Authors: Lajus Dmitry L.
Published: February 2023

This study addresses the problem of concordance in fluctuating asymmetry (FA) across traits by analyzing the relationship between FAs and the mean values of character measurements in a set of morphological traits. Regression slopes vary in natural populations, thus, revealing discordance in FA across traits among these populations. Hence, commonly accepted techniques for measuring developmental instability with FA result in uncertainties. Here, I relate FA to mean as a two-dimensional complex to demonstrate the uniformly negative slopes of standardized FA vs. mean value regressions for sets of morphological traits from eighteen distinct natural marine and aquatic populations. Comprehensive analysis of the FA–mean complex cannot be recommended for wide use in assessing stress and fitness, but it offers promise to improve FA measuring methodologies and to better understand the nature of developmental instability.
Evolution Analysis of Green Innovation in Small and Medium-Sized Manufacturing Enterprises
Authors: Song Zhiting , Zhu Jianhua , Shi Jianfeng
Published: February 2023

In recent years, green innovation has gained substantial attention and popularity from the manufacturing industry around the world. As an essential part of the manufacturing industry, small and medium-sized manufacturing enterprises (SMMEs) are vital participants that promote green innovation to realize sustainable development. However, how green innovation evolves in SMMEs is unclear, which hinders SMMEs from implementing or even adopting green innovation. This study attempted to essentially reveal the evolution of green innovation in SMMEs based on complex systems theory. First, this study divided green innovation into green product innovation and green process innovation, defined the state variables of the two components, and dissected the symbiotic interactions between them. This study then designed a nonlinear dynamic model followed by extensive simulations to theoretically and visually describe how green innovation evolves. This study found that green innovation with non-zero levels in both dimensions is desired and determines the evolutionary paths with corresponding measures that can guide SMMEs to realize green innovation at desired stable states. Besides, symmetric mutualism is discovered to be the optimal symbiotic interaction. Based on these findings, regulatory subjects and SMMEs can duly adjust the inputs on green innovation and the symbiotic interactions within green innovation to better manage green innovation practices.
A Scoping Assessment of Implemented Toxicokinetic Models of Per- and Polyfluoro-Alkyl Substances, with a Focus on One-Compartment Models
Authors: East Alexander , Dawson Daniel E. , Brady Sydney , Vallero Daniel A. , Tornero-Velez Rogelio
Published: February 2023

Toxicokinetic (TK) models have been used for decades to estimate concentrations of per-and polyfluoroalkyl substances (PFAS) in serum. However, model complexity has varied across studies depending on the application and the state of the science. This scoping effort seeks to systematically map the current landscape of PFAS TK models by categorizing different trends and similarities across model type, PFAS, and use scenario. A literature review using Web of Science and SWIFT-Review was used to identify TK models used for PFAS. The assessment covered publications from 2005–2020. PFOA, the PFAS for which most models were designed, was included in 69 of the 92 papers, followed by PFOS with 60, PFHxS with 22, and PFNA with 15. Only 4 of the 92 papers did not include analysis of PFOA, PFOS, PFNA, or PFHxS. Within the corpus, 50 papers contained a one-compartment model, 17 two-compartment models were found, and 33 used physiologically based pharmacokinetic (PBTK) models. The scoping assessment suggests that scientific interest has centered around two chemicals—PFOA and PFOS—and most analyses use one-compartment models in human exposure scenarios.
The Molecular Composition of Peptide Toxins in the Venom of Spider Lycosa coelestis as Revealed by cDNA Library and Transcriptomic Sequencing
Authors: Wu Xiangyue , Chen Yan , Liu Hao , Kong Xiangjin , Liang Xinyao , Zhang Yu , Tang Cheng , Liu Zhonghua
Published: February 2023

In the so-called “struggle for existence” competition, the venomous animals developed a smart and effective strategy, envenomation, for predation and defense. Biochemical analysis revealed that animal venoms are chemical pools of proteinase, peptide toxins, and small organic molecules with various biological activities. Of them, peptide toxins are of great molecular diversity and possess the capacity to modulate the activity of ion channels, the second largest group of drug targets expressed on the cell membrane, which makes them a rich resource for developing peptide drug pioneers. The spider Lycosa coelestis (L. coelestis) commonly found in farmland in China is a dominant natural enemy of agricultural pests; however, its venom composition and activity were never explored. Herein, we conducted cDNA library and transcriptomic sequencing of the venom gland of L. coelestis, which identified 1131 high-quality expressed sequence tags (ESTs), grouped into three categories denoted as toxin-like ESTs (597, 52.79%), cellular component ESTs (357, 31.56%), and non-matched ESTs (177, 15.65%). These toxin-like ESTs encode 98 non-reductant toxins, which are artificially divided into 11 families based on their sequence homology and cysteine frameworks (2–14 cysteines forming 1–7 disulfide bonds to stabilize the toxin structure). Furthermore, RP-HPLC purification combined with off-line MALDI-TOF analysis have detected 147 different peptides physically existing in the venom of L. coelestis. Electrophysiology analysis confirmed that the venom preferably inhibits the voltage-gated calcium channels in rat dorsal root ganglion neurons. Altogether, the present study has added a great lot of new members to the spider toxin superfamily and built the foundation for characterizing novel active peptides in the L. coelestis venom.
Role of Biomarkers in Detecting Acute Rejection in Kidney Transplantation
Authors: Salvadori Maurizio
Published: February 2023

Medicine has evolved from the so-called experience-based medicine to evidence-based medicine, which is now evolving into precision-based medicine [...]
LRP2 and DOCK8 Are Potential Antigens for mRNA Vaccine Development in Immunologically ‘Cold’ KIRC Tumours
Authors: Zhang Shichao , Xia Kaide , Chang Yue , Wei Yimei , Xiong Yu , Tang Fuzhou , Peng Jian , Ouyang Yan
Published: February 2023

The administration of mRNA-based tumour vaccines is considered a promising strategy in tumour immunotherapy, although its application against kidney renal clear cell carcinoma (KIRC) is still at its infancy stage. The purpose of this study was to identify potential antigens and to further select suitable patients for vaccination. Gene expression data and clinical information were retrieved from Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases. GEPIA2 was used to evaluate the prognostic value of selected antigens. The relationship of antigens presenting cell infiltration with antigen expression was evaluated by TIMER, and immune subtypes were determined using unsupervised cluster analysis. Tumour antigens LRP2 and DOCK8, which are associated with prognosis and tumour-infiltrating antigen-presenting cells, were identified in KIRC. A total of six immune subtypes were identified, and patients with immune subtype 1–4 (IS1–4) tumours had an immune ‘cold’ phenotype, a higher tumour mutation burden, and poor survival. Moreover, these immune subtypes showed significant differences in the expression of immune checkpoint and immunogenic cell death modulators. Finally, the immune landscape of KIRC revealed the immune-related cell components in individual patients. This study suggests that LRP2 and DOCK8 are potential KIRC antigens in the development of mRNA vaccines, and patients with immune subtypes IS1–4 are suitable for vaccination.
In Vitro Expansion of Vδ1+ T Cells from Cord Blood by Using Artificial Antigen-Presenting Cells and Anti-CD3 Antibody
Authors: Hur Gaeun , Choi Haeyoun , Lee Yunkyeong , Sohn Hyun-Jung , Kim Su-Yeon , Kim Tai-Gyu
Published: February 2023

γδ T cells have the potential for adoptive immunotherapy since they respond to bacteria, viruses, and tumors. However, these cells represent a small fraction of the peripheral T-cell pool and require activation and proliferation for clinical benefits. In cord blood, there are some γδ T cells, which exhibit a naïve phenotype, and mostly include Vδ1+ T cells. In this study, we investigated the effect of CD3 signaling on cord blood γδ T-cell proliferation using K562-based artificial antigen presenting cells expressing costimulatory molecules. There were significantly more Vδ1+ T cells in the group stimulated with anti-CD3 antibody than in the group without. In cultured Vδ1+ T cells, DNAM-1 and NKG2D were highly expressed, but NKp30 and NKp44 showed low expression. Among various target cells, Vδ1+ T cells showed the highest cytotoxicity against U937 cells, but Daudi and Raji cells were not susceptible to Vδ1+ T cells. The major cytokines secreted by Vδ1+ T cells responding to U937 cells were Granzyme B, IFN-γ, and sFasL. Cytotoxicity by Vδ1+ T cells correlated with the expression level of PVR and Nectin of DNAM-1 ligands on the surface of target cells. Compared to Vδ2+ T cells in peripheral blood, cord blood Vδ1+ T cells showed varying cytotoxicity patterns depending on the target cells. Here, we determined the ideal conditions for culturing cord blood Vδ1+ T cells by observing that Vδ1+ T cells were more sensitive to CD3 signals than other subtypes of γδ T cells in cord blood. Cultured cord blood Vδ1+ T cells recognized target cells through activating receptors and secreted numerous cytotoxic cytokines. These results are useful for the development of tumor immunotherapy based on γδ T cells.
Selenium Concentration Levels in Two Polluted Lagoons, Eastern Red Sea Coastal Waters
Authors: Ibrahim Ahmed S. A. , Al-Farawati Radwan
Published: February 2023

The importance of selenium in the marine environment is highlighted by its bilateral behavior as a nutrient and toxic element. The cathodic stripping voltammetry validated method was used to determine the selenium concentration. The concentration of total dissolved selenium (TDSe) in Al-Arbaeen and Sharm Obhur lagoons along the eastern Red Sea coastal waters was determined. The total selenium concentration in seven fish species’ muscles was determined. TDSe in the surface water of Al-Arbaeen and Sharm Obhur lagoons showed a maximum concentration of 18.56 and 8.38 nM, respectively. TDSe in the surface water of Al-Arbaeen revealed high concentrations near the wastewater discharging pipes in the lagoon. The linear regression between the TDSe and salinity reflected that the discharged water is the source of selenium with a significant negative correlation of (R2 = 0.80, p < 0.05). In contrast, TDSe in the surface water of Sharm Obhur showed a significant positive correlation (R2 = 0.78, p < 0.05). In the lagoon head, hypoxic and anoxic conditions were dominant. This condition reflected the low TDSe concentration and may affect the selenium chemical forms’ abundance in the lagoon. Two fish species Herklotsichthys punctatus and Herklotsichthys revealed high concentrations of 3.99 and 2.40 µg/g, respectively, which exceeded the permissible levels of the WHO, FAO, and ASTDR.
Experimental Study on the Purification Mechanism of Mine Water by Coal Gangue
Authors: Zhu Liu , Yao Qiangling , Xu Qiang , Li Yinghu , Li Xuehua
Published: February 2023

Coal mining has caused groundwater pollution and loss. Using a mined area as a water storage space for storing and purifying mine water is a low-cost environmentally friendly mining method. In this study, static and dynamic adsorption experiments on the ions in mine water were carried out using the roof rocks from the Lingxin coal mine. The sample analysis results show that the main chemical composition of the roof is mainly SiO2 and Al2O3. The water chemistry type of the mine water is SO4-HCO3-Cl-Na type, with an average mineralization of about 4000 mg/L. The experimental results show that gangue can stabilize the pH value of mine water with different pH values between 7.5 and 8.5. In the acidic and alkaline environment, the degree of void space increases the adsorption capacity of the gangue, in which the adsorption rate of gangue is between 3% and 5%. The calcium ion reduction rate reaches 75% in static leaching and 70% in dynamic leaching conditions. Medium-grained coarse sandstone has a stronger adsorption capacity than muddy siltstone. The results from this study can support further research on using gangue for water purification purposes in mines, simultaneously reducing the harmful accumulation of gangue and promoting the recycling of highly mineralized water.
Bioinformatics Analysis Reveals a Shared Pathway for Common Forms of Adult Nephrotic Syndrome
Authors: Li DengFeng , Liu Liang , Murea Mariana , Freedman Barry I. , Ma Lijun
Published: February 2023

Key Points

Dysregulation of the focal adhesion pathway is present in the three most common forms of glomerular disease, that is, Focal segmental glomerulosclerosis, membranous nephropathy, and minimal change disease.

Zyxin is seen to be upregulated in the glomerular compartment of patients with the three most common forms of glomerular disease.

Background

Focal segmental glomerulosclerosis, membranous nephropathy, and minimal change disease are common causes of nephrotic syndrome. Although triggers for these diseases differ, disease progression may share common molecular mechanisms. The aim of this study was to investigate the presence of molecular pathways that are dysregulated across these glomerular diseases.

Methods

The gene expression dataset GSE200828 from the Nephrotic Syndrome Study Network study was obtained from the Gene Expression Omnibus database. R and Python packages, Cytoscape software, and online tools (DAVID and STRING) were used to identify core genes and topologically relevant nodes and molecular pathways. Single-cell RNA sequencing analysis was applied to identify the expression patterns of core genes across kidney cell types in glomerular compartments.

Results

A total of 1087 differentially expressed genes were identified, including 691 upregulated genes and 396 downregulated genes, which are common in all three forms of nephrotic syndrome compared with kidney donor controls (FDR P<0.01). A multiapproach bioinformatics analysis narrowed down to 28 similarly dysregulated genes across the three proteinuric glomerulopathies. The most topologically relevant nodes belonged to the adherens junction, focal adhesion, and cytoskeleton pathways, where zyxin covers all of those gene ontology terms.

Conclusions

We report that dysregulation of cell adhesion complexes was present in the three most common forms of glomerular disease. Zyxin could be a biomarker in all three common forms of nephrotic syndrome. If further functional studies confirm its role in their development, zyxin could be a potential therapeutic target.
Practices for readiness of future specialists for professional self-determination in the information society
Authors: Knysh Inna , Dubinka Mykola , Kochubei Olena , Poliakov Ihor , Tiahur Vasyl
Published: February 2023

Professional self-determination of the individual is a complex and lengthy process of finding and realizing yourself in the profession. The main goal of professional self-determination is clarified. The basic concepts of readiness for professional self-determination of future specialists in the modern information society are revealed. The following approaches to the consideration of the concept of readiness are defined: functional-psychological, personal, activity-based. Based on the components of readiness identified by the researchers, it can be assumed that the structure of professional self-determination of the future specialist contains motivational, cognitive and activity components. Self-determination is defined as a multidimensional process that can be considered from different points of view: as a series of tasks, that society sets for the emerging individual, and which the individual must solve in a certain period. As a process of step-by-step decision-making, with the help of which the individual forms a balance between his desires and inclinations, on the one hand, and the needs of society, on the other; as a process of forming an individual lifestyle, part of which is professional activity. A number of tasks of professional self-determination of a future specialist in the information society are formulated.
Prosodic means’ interaction in realising the anecdote humorous effect
Authors: Taranenko Larysa , Aleksenko Svitlana
Published: February 2023

In the paper, on the basis of auditory analysis of English spoken anecdotes the authors come up with the system of prosodic means that serve to create the text humorous effect. To define the specificity of a complex interaction of emotional, pragmatic, structural and semantic factors of prosodic means’ functioning in English anecdotes, we substantiated two algorithmic models presenting the text story-line development: one being similar to the structure of the fairy tale (introduction → commentary → code), and the other one resembling the riddle (topic → commentary → code). By way of using these models as well as the traditional method of linguistic interpretation of the auditory analysis results, the authors substantiate the specificity of prosodic, lexico-grammatical and stylistic means interaction of an English anecdote oral actualisation functioning within its structural components. It has been found out that realisation of the anecdote humorous effect is ensured by the predominance of the unidirectional functioning of the language means of all levels with the leading role of prosodic means aimed at drawing the listeners’ attention to the anecdote’s two-plane semantics and its key lexical units, thus stimulating their thinking activities while decoding the humour of the anecdote. The authors come to the conclusion that the application of a functional-and-energetic approach to the study of a complex interaction of emotional, pragmatic, semantic and structural factors makes it possible to present a comprehensive description of invariant and variant prosodic patterns of any type of texts.
Archaic archetypes and symbols of the Ukrainian and Russian peoples: to debunk the myth of a single people
Authors: Binbin Shen , Kravchenko Nataliia , Matvieieva Svitlana
Published: February 2023

The article models the protocultural fields of the archetypal-mythological memory of Ukrainians and Russians as consisting of divergent elements. The core of the fields are archaic cultural archetypes and archetypal motifs “mother”, “field”, “plowman”, “labor”, “individualism”, and “equality” for Ukrainians, and “father”, “distance”, “vastness”, “inertia”, “collectivism”, and “submission” for Russians. The сore archetypes determine the differences in the ethnic mentality of two peoples and can enter the subsequent semiospheres and political mythology without significant adaptation, transforming into symbols of national identity. The periphery is formed by archetypes common, but re-articulated in subsequent semiospheres to be adapted to national narratives of different periods. The general archetype Sacred space was associated in the archaic consciousness of Ukrainians with the “House”, symbolizing the maternal principle and the Motherland, while the Russians embodied this archetype in the symbols of the Holy Mountain, metonymically expanded to the symbols of “Holy Rus”, Heartland, Rimland, defining the motif of messianism in symbolic politics of Russia. The archetype of the Hero is manifested in Ukrainian folklore by the images of the legendary plowmen, who conquer the steppe elements from the nomads, while in the Russian ethnic consciousness it is interpreted as the Messiah-Savior of the world.
Digitization process in the local self-government: International-legal experience
Authors: Perezhniak Boris , Vasylchuk Larysa , Bevz Tetiana , Pyroha Serhii , Batan Yurii
Published: February 2023

Digitalization of the activity of state authorities and local self-government bodies significantly facilitates communication between citizens, the state, and businesses. In modern conditions of globalization and comprehensive digitalization of the service sector, the development and implementation of digital technologies in the field of local self-government are taking place. Due to this, the authors analyzed how the transformational path to digitization in the field of local self-government in Ukraine and abroad is taking place in detail. The purpose of the work is to study the international legal experience of digitalization of local self-government, to determine the main advantages and problematic aspects, as well as the peculiarities of the implementation of digitalization tools in municipal administration. The methodological basis of this study is such methods as logical generalization, method of economic analysis, method of comparison, graphic methods, method of theoretical generalization, the system method, methods of positive and normative analysis, metaphysical method, historical method, synergistic method, and intuitive method. As a result of the conducted research, both the national and international experience of digitalization of local authorities were analyzed and the prospects for the development of digital management tools in the near future were noted.
Methodic of professionally-oriented English-language competence formation in monologue-presentation of future designers
Authors: Kornyeyeva Irene , Makhovych Inna
Published: February 2023

This paper offers the methodic of professionally-oriented English-language competence formation (POELCF) in monologue-presentation (MP) of future designers (FD). The relevance of the research is determined by social order of society to train professionals capable for professional foreign-language communication; the contradiction between the specified program documents requirements and current state of English-language learning in Ukraine; the need of future designers to have professionally-oriented English-language-monologue for effective foreign-language communication. The purpose of the study is to substantiate the developed and experimentally tested methodic. We can outline the results of the present study: the peculiarities of the POELCF are defined, which are founded the base of the corresponding Methodology; the author’s system of exercises for learning the monologue-presentation-report, monologue-presentation-advertising; the definition of monologue-presentation is proposed as the target type of monologue utterance of future designers; linguistic analysis of the “monologue-presentation” discourse was conducted; checking experiment results are submitted. We make a conclusion: monologue-presentation is the most demanded and convenient target type of monologue broadcasting of future designers, who are capable to rebuild our Motherland after the War against Russian invaders and consolidate all European community.
Value of the acute asthma intensity research score (AAIRS) for asthma exacerbations in children
Authors: Bui Binh Bao Son , Pham Trong Phu , Do Ho Tinh Tam
Published: February 2023

Background: Correct severity assessment of asthma exacerbations helps in appropriate management. The purpose of the study was to investigate the value of the Acute Asthma Intensity Research Score (AAIRS) in assessing the severity of asthma exacerbations in children. Methods: A cross-sectional descriptive study was conducted in 226 children aged 1-15 years admitted with asthma exacerbations from April 2018 to June 2020. Results: The majority of children were admitted with severe asthma exacerbations (44.2% in children aged 1-5 years and 85.5% in children aged 6-15 years). The prevalence of mild, moderate, and severe AAIRS were 31.0%, 56.6%, and 12.4%, respectively. In children 5 years and younger, AAIRS ≥ 9 had a sensitivity of
73.81% and a specificity of 83.02% in the classification of severe asthma exacerbations according to the guidelines of Vietnam Ministry of Health (AUC = 0.833) with Cohen’s kappa coefficient k = 0.17. In children aged 6-15 years, AAIRS ≥ 6 had a sensitivity of 89.29% and a specificity of 100% in the classification of severe asthma exacerbations according to the GINA guidelines (AUC = 0.951) with Cohen’s kappa coefficient k = 0.56. Conclusion: The AAIRS was not a substitute for current guidelines for assessing asthma exacerbation severity, especially in children aged 1-5 years.
Key words: asthma exacerbations, AAIRS, children
Clinical and Doppler echocardiography characteristics in children with ventricular septal defect
Authors: Do Ho Tinh Tam
Published: February 2023

Background: Ventricular septal defect is the most common congenital heart disease. Without early diagnosis and appropriate treatments, this disease can lead to many complications. Objectives: To describe clinical and Doppler echocardiography characteristics of the ventricular septal defect in children; To determine the relevance between clinical and Doppler echocardiography symptoms. Subjects and methods: 56 patients from 0 months to 15 years of age were diagnosed with ventricular septal defect and admitted to Pediatric Center - Hue Central Hospital from March 2018 to April 2019. Set up a cross-sectional study. Results: The most common symptoms are sweating, exercise intolerance, failure to thrive, systolic murmur, and hyperactive precordium. The majority of patients had complications. Over 90 percent of defects were perimembranous. The percentage of failure to thrive, persistent tachypnea, sweating, Harzer sign, reduced murmur intensity, and malnutrition in the group with severe or fixed pulmonary arterial hypertension was higher with statistical significance. Conclusion: Most children with ventricular septal defects were hospitalized with symptoms and complications. Most defects are medium and large on Doppler echocardiography. There is a significant association between symptoms failure to thrive, persistent tachypnea, sweating, chest deformity, Harzer’s sign, reduced murmur intensity, and complications malnutrition and heart failure with the severity of pulmonary arterial pressure hypertension.
Key words: clinical, Doppler echocardiography, ventricular septal defect
In silico inhibitory activities of flavonoid and curcumin derivatives against GP IIb/IIIa receptor
Authors: Vo Thi Quynh Nhi , Nguyen Thinh Tin , Cao Thi Cam Nhung , Nguyen Thanh Bich Chau , Tran The Huan , Tran Thai Son
Published: February 2023

Background: Over the past 15 years, thrombosis has been one of the most common causes of death. Current antiplatelet therapies could limit the morbidity and mortality from thromboembolic diseases, but they still have side effects such as uncontrolled bleeding, and patients’ intolerance. Therefore, finding new antiplatelet agents is an important goal in improving the treatment of thrombotic diseases. Objective: To design flavonoid and curcumin derivatives that inhibit the glycoprotein (GP) IIb/IIIa receptor, which plays an important role in platelet aggregation. Materials and Methods: In silico models were built to predict the biological activities of chemical compounds. These models were used in virtual screening, and new structures were designed from most promising molecules. Results: The 2D-QSAR and molecular docking models were developed with good
predictability. From the virtual screening process, 16 curcumin and 29 flavonoid derivatives were obtained with potential activities on target protein. Two substances S4 and S35 were selected for structural optimization, and two new compounds with the greatest potential for further research were found. Conclusion: The study will contribute to the orientation of finding lead compounds capable of inhibiting the receptor GP IIb/IIIa, thereby shortening the time to search for new substances in the treatment of thrombotic diseases.
Key words: Thrombosis, GP IIb/IIIa receptor, in silico, QSAR, molecular docking, flavonoid, curcumin.
Psychological stress in women with ovarian tumors
Authors: Le Lam Huong , Le Minh Tam , Nguyen Thi Phuong Dung , Vo Hoang Lam , Vo Van Khoa
Published: February 2023

Objective: To determine the level of psychological stress in women with ovarian tumors. Methods: A crosssectional description of 461 women hospitalized with ovarian tumors at Hue Central Hospital and Hue University of Medicine and Pharmacy Hospital from January 2019 to December 2020. Selection criteria: Ovarian tumor had surgical indication. There were histopathological results after surgery. They were accepted to participate in the study. Results: 65.2% of benign ovarian tumors and 93.8% of malignant ovarian tumors exhibited anxiety and depression. In the group of benign ovarian tumors, irritation for 42.2%, but it accounted for 47.7% in the group of malignant ovarian tumors. In the group of malignant ovarian tumors, the prevalence of depressive symptoms was 98.5% (p < 0.05). Fear was reported by 47.9% and 95.4% of the population, respectively (p < 0.05). In terms of physical health, the benign ovarian tumor group had an average level of 75%. In contrast, the malignant ovarian tumor group had 9.2%, with low and deficient levels of 86.2% and 4.6%, respectively.
Regarding the quality of mental life, the rate of those with a high level was 0%. The average percentage of benign ovarian tumors was 69.4%, while the rate of malignant ovarian tumors was 29.2%. In contrast, the lowgrade portions were 19.2% and 38.5%, respectively. 49% of patients with benign tumors had low psychological stress. The intermediate and high levels of psychological stress were 35.1% and 24.0%, respectively. 73.8% of patients with malignant ovarian tumors had a significant level of psychological stress. Conclusion: In terms of physical and mental health, the quality of life in the ovarian tumor group was intermediate average. Patients with malignant ovarian tumors had highly elevated levels of psychological stress.
Key words: Quality of life, ovarian tumor, ovarian cancer.
The impact of Covid-19 pandemic on Gastroenterology Department activity of Da Nang Hospital
Authors: Nguyen Thanh Trung , Le Duc Nhan , Doan Hieu Trung , Mai Van Thuat
Published: February 2023

Objective: Covid-19 is a global pandemic that severely affects healthcare systems around the world. The aim of this study was to evaluate the impact of Covid-19 in the treatment and operation of the Department of Gastroenterology, Da Nang Hospital. Materials and menthods: Retrospective descriptive study was conducted from January 1, 2019 to December 31, 2020 at the Department of Gastroenterology, Da Nang Hospital. Results: During the period of 02 years, a total of 12,282 patients were included to our analysis (in 2019: 7838 patients, with 54.4% male 45.6% female, mean age 51, 46 ± 18.87 years. In 2020: 4446 patients with 57.2% male and 42.8% female, mean age 52.05 ± 18.36 years). During the Covid-19 epidemic, the most common groups of hospitalized symptoms included melena (7.3%), Hematochezia (6.3%), Hematemesis (6.3%) and jaundice (8.3%). Similarly, the disease groups increased the rate of hospitalization such as gastric ulcer (15.6% compared to before the epidemic 11.9%, p < 0.001), combined gastro-duodenum ulcer (4.7% compared to 3.1%, p < 0.01), stomach cancer (5.1% vs 3.4%, p < 0.01), colorectal cancer (14.7% vs 10.3%, p < 0.01), cirrhosis (58% vs 54.4%, p < 0.05), acute hepatitis (9.7% vs 5.8%, p < 0.05), acute pancreatitis (70.7% versus 63.1%, p < 0.05). In particular, the number of gastrointestinal endoscopy decreased significantly during the Covid-19 epidemic compared with before the epidemic (17156 timescompared with 10880, p < 0.001), of which the number of gastroscopy and ERCP was mainly reduced. In contrast, the rate of emergency endoscopy increased significantly compared to the pre-epidemic period (6.69% vs 5.85%, p < 0.01), so the number of endoscopy intervention also increased significantly (5.29% vs 2.71%, p < 0.001) as well as the need for surgical intervention also increased (5.6% vs 4.2%, p < 0.001). The rate of patients with complications and death was also higher during the Covid-19 epidemic than before the epidemic, respectively (2.5% vs 1.7%, p < 0.01), mortality (1.4% vs 0.9%, p < 0.01) and duration of hospitalization were also longer (6.7 ± 4.54 vs 6.44 ± 4.68 days, p < 0.01). Conclusion: The Covid-19 pandemic has significantly reduced the number of patients at the Department of Gastroenterology, Da Nang Hospital. It is necessary to change the mode of operation to flexibly adapt to the current situation. Thereby helping to significantly reduce the impact on non-Covid-19 patients
Key words: Covid-19 pandemic, Department of Gastroenterology, Da Nang Hospital
Assessment of Waste Management Efficiency Using Subjective and Objective Indicators in 26 Major Chinese Cities
Authors: Xiao Lishan , Ye Hong , Xu Su , Lin Tao
Published: February 2023

Waste management (WM) is a complex social–ecological system that should be evaluated by socioeconomic and environmental indicators. A new waste separation strategy was implemented in China in 2017. Whether the high recycling target in this strategy is conducive to the sustainability of the WM system remains uncertain, and the effects of public satisfaction on WM efficiency should be further assessed. This research used data envelopment analysis and a Malmquist index to incorporate both objective and subjective indicators. The results showed that half of the selected cities achieved managerial efficiency and that WM efficiency improved substantially after the implementation of the new strategy. Geodetector analysis found that satisfaction was driven by economic factors and environmental impacts. Sensitivity analysis confirmed that food recycling rate positively affected WM efficiency, but with diminishing marginal returns. The influence of environmental emissions and resident satisfaction on WM efficiency both increased with the recycling rate. When the recycling rate rose more than 33%, environmental satisfaction exerted a stronger influence on WM efficiency than environmental emissions. The results indicated that the combined application of objective and subjective indicators is necessary to accurately reflect changes in WM efficiency. Efforts to improve WM efficiency in China should focus on cities with low and declining efficiency, and increasing resident satisfaction and reducing CO
2
emissions will be primary paths to achieve efficiency improvements in future.
Game Theoretical-Based Logistics Costs Analysis: A Review (ITALIC)
Authors: Teja Sukmana Husni , Emmanuel Widjaja Andree , Situmorang Hery Juan
Published: February 2023

As the range and complexity of outsourced services for logistics increase, Logistics has evolved into a distinct commercial service. The question of how to fairly charge logistics services has grown urgent. In this study, we conduct a comprehensive evaluation of the academic research on the cost of logistics services employing bibliometric and analyzing the content methodologies, with a focus on the application of game theory. Using three criteria logistics situations, game models, and influencing factors, we contrast and evaluate the research. This research examines the important stakeholders and research situations in logistics pricing examine the most suitable and often utilized game models, as well as highlights the primary elements determining logistics pricing. To close the gaps in our current understanding, we offer potential study directions. The present level of evidence-based study in the area of price for logistics is thoroughly reviewed in this work, this contributes to the creation of new models. From a pricing perspective, the results of this investigation are helpful in the advancement of logistics services, as a result, logistical activities will be more economical as well as environmentally sustainable.
The Digital Economy's Use of Big Data (ITALIC)
Authors: Wahyudi Mochamad , Meilinda Vivi , Khoirunisa Alfiah
Published: February 2023

The function of Big Data technology and Data Science in the contemporary digital economy is examined in this article. According to the author, large and medium-sized businesses in the retail and service sectors have a greater interest in utilizing them. Banks, mobile operators, and major manufacturing firms actively employ these technologies (Artificial Intelligence) to evaluate data on equipment failures and minimize downtime, which enables cost-reduction. Big Data technology serves as a liquid product and a prerequisite for boosting business profitability through individualized customer care and predictive analytics. It is crucial to ensure the formation of unique data exchanges and legalize a single definition of big data for the modern digital economy.
Functions of Artificial Intelligence, Income Investment Instrument, and Crypto Money in Era of The Fourth Revolution (ITALIC)
Authors: Sriliasta Cicilia , Surya Wuisan Dewi Sri , Mariyanti Tatik
Published: February 2023

This research examines those related to Artificial Intelligence, stock robotics, and revenue intruments portfolio diversity in the context of the Fourth Industrial Revolution era, artificial intelligence, and concern for the environment. First, our results suggest that a portfolio of these assets is highly dependent, suggesting that large mutual losses are likely to occur during times of disruption in the economy. Second, it supports a large market mood in the near future, indicating that this disruption in the approaching time can increase the market mood of assets, while to support the market mood decreases for a long time.
Machine Learning and Artificial Intelligence as Educational Games
Authors: Sunarya Po Abas
Published: February 2023

Digital games are establishing themselves as a new paradigm in teaching. Everyone can play digital games, they're economical, and they're a terrific way to learn. Digital games that encourage computational thinking and programming have recently attracted more attention in pre-college (K–12) educational institutions. A growing number of students have been drawn to the subjects of In recent years, there has been an increase in artificial intelligence (AI) and machine learning (ML). Researchers in teaching and learning are interested in the integration of AI/ML with digital gaming, however there hasn't been a literature review in this field. This paper aims to summarize the most recent findings on instructional video games for AI and ML. A qualitative content analysis was conducted using the relevant essays and games that were selected following a comprehensive search. Using this summary as a base, we present a list of research publications and games that are relevant. illustrating the unique opportunities that diverse games offer to teach various AI and ML techniques and topics.
Analysis of the Influence of Quality of Education Services and Facilities and Infrastructure on the Trust of the Community of Boarding Boards Az - Ziyadah with Satisfaction as a Mediation Variable
Authors: Laila Nur , Guswandi Guswandi , Subagja Iwan Kurniawan
Published: February 2023

This study aims to: 1) test and analyze the effect of Quality of Education Services and Infrastructure Facilities on Satisfaction, 2) test and analyze the effect of Quality of Educational Services Community Trust, 3) test and analyze the effect of Satisfaction on Public Trust, 4) test and analyze the effect of Quality Education Services on Public Trust through Satisfaction, 5) test and analyze the influence of Infrastructure on Public Trust through Satisfaction at the Az Ziyadah Islamic Boarding School, East Jakarta. The research was conducted at the Az Ziyadah Islamic Boarding School in East Jakarta with a research sample of 175 respondents. Sampling technique used is the Simple Random Sampling. The data analysis method used is path analysis. The results of the study show that: 1) There is an influence of Quality Educational Services and Infrastructure Facilities on Satisfaction. 2) There is an influence of the Quality of Educational Services and Infrastructure Facilities on Public Trust. 3) There is an influence of Satisfaction on Public Trust. 4) There is an influence of the Quality of Educational Services on Public Trust through Satisfaction. 5) There is an influence of Infrastructure to Public Trust through Satisfaction at the Az Ziyadah Islamic Boarding School, East Jakarta.
The Effect of Load and Stress on Work Performance with Motivation as a Moderation Variable (Case Study at the Ministry of Religious Affairs of the Republic of Indonesia)
Authors: Rahim Dian Anggraeny , Sjafrudin Asep , Prafitaningrum Dewi
Published: February 2023

This study aims to analyze the effect of burden and stress on the work performance of employees of the Ministry of Religious Affairs of the Republic of Indonesia with motivation as a moderation variable. One of the main duties of the Ministry of Religious Affairs of the Republic of Indonesia is to provide services to the community related to education in the level of kindergarten to university in Indonesia. Given the large work area of employees and the heavy workload in the ministry, it is not uncommon for employees to lose motivation at work, that makes the achievement is low. 97 employees were involved in this study. Using the SEM-PLS method, the results of this study show that the indicator reliability, Cronbach alpha, composite reliability and AVE values are valid. The discriminant validity value is greater than the factor charge value. Workload negatively influences work performance either directly or indirectly, moderated by motivation. Work stress positively influences work performance directly or indirectly, moderated by motivation. Motivation has a positive influence on work performance.
Gestión estratégica de una ciudad
Authors:   , Marinangelli María Ileana
Published: February 2023

Se aborda la gestión y planificación estratégica de las ciudades, desde una concreta perspectiva tomando como objeto de estudio a dos ciudades que, inmersas en contextos muy disimiles, llegan a mantener ciertos rasgos comunes que habilitan una comparación a partir de una serie de criterios que a tal propósito se definen. Las ciudades son Barcelona (España) y La Plata (Argentina), consideradas como ciudades en sí mismas y con el contorno de superficie urbanizada que las circunda en forma inmediata, más no como siendo parte de áreas metropolitanas en las que están inmersas. El escrito comienza formulando un objetivo general y tres objetivos específicos, seguidos de una muy breve referencia a modo de proceder metodológico desarrollado. En un primer apartado se consagra una enunciación específica sobre nociones de gestión y planificación estratégica de ciudades. Se procede a plantear un análisis de cómo fue la formulación e implementación de planes estratégicos en Barcelona y en La Plata durante las últimas décadas, y el tercero y último de la sección exponiendo un análisis comparativo de ambas ciudades en función de una breve serie de criterios definidos para ello.