bluuebunny/crossref_metadata_2025 huggingface dataset:
Avaliação da genotoxidade e citoxidade do Gligofosato em Allium cepa
Authors: Barzotto Ana Carolina , Vanini Julia , Busin Carmen Silvia
Published: January 2023

O modelo atual de agricultura tem buscado a elevação da produtividade e a potencialização de lucros com utilização extensiva de agroquímicos, dentre os quais se encontram os agrotóxicos. Os herbicidas são os mais empregados, sendo o glifosato puro e as suas formulações, os mais utilizados por apresentarem amplo espectro, contemplando uma ampla variedade de plantas. Com o intuito de verificar os danos ocasionados por estes químicos, diversos métodos de avaliação tem sido utilizados, dentre eles o Teste Allium cepa (cebola), um excelente bioindicador em testes de monitoramento da toxicidade e da genotoxicidade de poluentes ambientais. O objetivo do presente trabalho foi avaliar a genotoxicidade e a citotoxicidade do herbicida glifosato, utilizando o teste Allium cepa. Na avaliação da genotoxicidade foi utilizado como parâmetro as frequências de micronúcleos e de anormalidades da anáfase-telófases e, na avaliação da citotoxicidade, utilizou-se o comprimento das raízes e o índice mitótico. O experimento contou com cinco bulbos de cebola para cada uma das concentrações 65?l/L, 130?l/L e 260?l/L e mais cinco para controle negativo estes, imersos somente em água destilada. As cebolas tiveram seus bulbos imersos por 24 horas em água da torneira para estimular o crescimento, posteriormente as mesmas foram colocadas nas diferentes soluções e, após 48 horas foi efetuada a coleta das raízes e montagem das lâminas. Os resultados indicaram aumento significativo em anormalidades na anáfase-telófase relacionadas com o aumento nas concentrações, bem como uma significativa redução no crescimento das raízes e no índice mitótico nas concentrações de 130 ?l/Le 260 ?l/L, quando comparados aos resultados das cebolas do controle. Sendo assim, conclui-se que nas concentrações de 130 ?l/Le 260 ?l/L o herbicida glifosato desempenha papel genotóxico e citotóxico no organismo teste.
Minimally Invasive Foot and Ankle Surgery: A Primer for Orthopaedic Surgeons
Authors: Lausé Gregory E. , Miller Christopher P. , Smith Jeremy T.
Published: January 2023

There is rapidly growing interest in minimally invasive surgery (MIS) of the foot and ankle. Technological advances, specifically with the advent of low-speed high-torque burrs, have enabled the expansion of MIS techniques. Accordingly, there is growing literature reporting excellent outcomes of MIS surgery to address many different pathologies of the foot and ankle. MIS techniques are particularly useful for conducting percutaneous osteotomies and bony débridement. These can be used to address bunion deformity, hammertoes, metatarsalgia, bunionette deformity, bone spurs, and hindfoot deformity. A detailed understanding of the technology, equipment, and techniques is crucial to safely conduct MIS of the foot and ankle. When done safely, MIS provides favorable outcomes with an expedited recovery and limited complications.
A Novel Framework for Routine Versus Critical Communication in Surgical Education—Don't Take It Personally
Authors: Falk David , Cline Preston , Donegan Derek , Mehta Samir
Published: January 2023

Despite their impressive academic track records and mastery of controlled classroom-based didactic learning, many orthopaedic surgery residents struggle to adjust from learning in the classroom environment in medical school to learning in the operating room as surgical residents. Instead of learning in lectures, surgical residents take on a more apprenticeship-based role with the goal of mastering technical skills in an experiential learning environment. Yet, no framework has been explicitly described in the literature to help learners make this transition. Consequently, we feel there is a need to clearly define the different learning environments and modes of communication, such that the residents can better understand how information is acquired and retained as well as how feedback is delivered in the operating room compared with more traditional spaces (eg, medical school classroom). The objectives of this summary are to (1) identify the major differences between learning in the classroom environment and the operating room and (2) introduce the concept of routine versus critical communication. We hope that by better defining the new learning environment with an emphasis on communication styles that may be encountered in this setting, learners can more easily make the transition from high-performing academicians to high-performing surgeons.
Evaluation of Levels of Urea and Creatinine, Comorbidity and Socioeconomic Status in Diabetic Patients
Authors: Asif Hina , Anwar Tehreem , Sarwar Sadia
Published: January 2023

Nephropathy occurs in 10±40% of patients who have Type I (insulin-dependent) diabetes mellitus [1±3]. The development of diabetic nephropathy cannot be explained by poor glycaemic control alone. Objectives: To determine the frequency, association of diabetes with gender, correlation of diabetes duration with urea and creatinine, co morbidity, socioeconomic status renal disease in diabetic patients. Methods: The study was carried out in Mayo Hospital. A total of 100 patients were included in this study from 1st November 2019 to 31st January 2020. Blood samples were collected from diabetic people for chemical analysis to determine the protein and Urea Creatinine Ratio (UCR). RFTs was done to calculate the urea/creatinine values and their ratios. Statistical analysis was performed by using SPSS software version 13. Results: The ratio of male and female diabetic patients was 60:40. Mean age of male diabetic patients was 53.67 years and of female diabetic patients was 50.42 years. Frequency of renal diseases in diabetic patients was 55%. A significant p-value was obtained from the correlation of duration of diabetes (yrs) with urea and creatinine (mg%). Frequency of co-morbidity in all diabetic patients was measured and the highest frequency was of heart diseases. Conclusions: We conclude that diabetes is the single main and leading cause of renal diseases. It is clear that diabetic kidney disease is becoming a problem in Pakistan. As long as the duration of diabetes increases there will be more chances of renal disease so the proper diagnose at time and management is very necessary.
Dengue Infected Patients in Local Population of Lahore
Authors: Akhtar Khunsa
Published: January 2023

Over the past 20 years, dengue fever's demographic characteristics have significantly altered in Pakistan. Different facets of particular epidemics have been covered in small-scale research from around the nation during this time. However, there is a dearth of information on the country's general trend of dengue virus infection. Objectives: To examine liver function test of dengue infected patients, age and gender wise distribution of dengue virus infected patients. Methods: During August-November 2011, patients with clinical presentation of DF, who came to Emergency department of Mayo Hospital Lahore, were included in this study. Total 64 patients were included in this study and LFTs  were performed photometrically to see the effect of dengue virus infection on liver of affected patients during early days of infection from 2-7 days. Results: Out of 64 patients, 47 were males and 17 were females. Dengue fever was more common among the age group of 16-25 years and less common among children and older age group. All the patients had low platelet level with 29 patients had complaint of bleeding. Serum raised level of ALT and ALP was observed in some patients. Conclusions: Presently widespread throughout the year with a high frequency in the post-monsoon season, dengue fever is currently endemic in Pakistan. The median patient age for dengue has dropped, and younger patients, particularly men, may be more vulnerable. Total and differential leukocyte counts can assist identify individuals who are at risk for bleeding, and LFTs can show whether dengue virus infection has an impact on the liver.
Treatment of older patients with multiple myeloma
Authors:   , Stege Claudia Antoinette Maria
Published: January 2023

General discussion
Over the last decades, the prognosis of non-transplant eligible (NTE) patients with newly diagnosed multiple myeloma (NDMM) has improved substantially.1-3 However, this benefit is less in older patients, both when treated within clinical studies as in those patients receiving standard of care.2,4-6 There are several explanations for the inferior survival of older patients with MM. Firstly, older patients more often receive doublet therapies, instead of the generally more potent triplets. Secondly, older patients experience more pronounced treatment related toxicity hampering optimal treatment, leading to relapse or may even lead to death.7 Thirdly, older patients are less likely to receive a subsequent line of treatment, which might be due to comorbidities, persistent toxicity related to former treatment, or the patient’s wish for palliation.8 Finally, older patients may receive no treatment at all because physicians feel reluctant to treat them of fear for treatment related complications.2,9,10 This in turn may lead to under-treatment of a relatively fit subgroup of patients, causing inferior outcome.11,12
In order to improve the outcome of older patients with NDMM, it is needed:
I. to identify fit versus non-fit patients, in order to personalize treatment;
II. to perform clinical trials to investigate the efficacy of treatment regimens in older patients according to their frailty level;
III. to obtain meticulous data on side effects and quality of life (QoL), since older non-fit patients might value side effects and the effect of treatment on QoL as more important factors that impact the choice for treatment than length of life only.13,14
This thesis aimed to fill part of these knowledge gaps in the treatment of NTE patients with NDMM.
In PART I we validated the current gold standard of frailty assessment in MM, the IMWG frailty index (IMWG-FI), as well as the simplified frailty index that is more commonly used in clinical trials. We refined the IMWG-FI in order to improve the prognostic value for outcome.
In PART II we investigated the value of novel treatment options that were hypothesized to be suitable for non-fit older patients with NDMM.
in PART III we investigated the impact of treatment on health-related quality of life (HRQoL).
Stability Control of Frequency and Voltage in Wind Power Plant Using Complementary Load with Pid Control, Pwm and Thingspeak Monitor
Authors: Hermanto Yuli , Kiswantono Agus
Published: January 2023

Utilization of wind energy (wind) that blows from a certain height which is then used to turn wind turbines and converted into electrical energy or so-called wind power plants (PLTB) is one solution to the problem of the energy crisis so far. In addition, voltage stability is very necessary in the continuity of the use of power plants. Unstable voltage and frequency make electrical equipment (load) easily damaged. There are various ways to reduce instability, one of which is using a pseudo/complementary load electronic control circuit. The point is that the generator will be loaded with a total load that is always constant, the load on the consumer plus the complementary (pseudo) load is equal to the nominal capacity of the generator. This research uses a 3 phase generator and a 3 phase induction motor as a driving machine, the main load uses a lamp and the pseudo load uses a heater. The main control uses a Dspic30f4012 microcontroller connected to a voltage sensor. The microcontroller works using PWM with feedback using PID, which then PWM provides pulse information to the load drive circuit. The use of PID in this control system will produce a voltage in the generator at 50 Hz and 220Vac whether there is a load or not. So that the voltage supplied to consumers is stable and does not damage electronic equipment.
Prototype of Solar Cell Automatic Charging Handphone as Alternative Sources of Electricity
Authors: Purwibawa Bagus Ageng , Saidah
Published: January 2023

Electrical energy has not been able to adequately meet the needs of communication equipment in the remote areas,especially at a location far from electrical energy sources such as when conducting natural tourism, traveling to thebeach or doing mountain climbing. Utilizing solar cell as an alternative source of electrical energy will support themanufacture of automatic charger equipment that will be supplied to the load of handphone where the method used inthe charging process is constant current and constant voltage.This method uses LM317 as its main component. Thedesign of this tool uses two 3000 mAh capacity batteries that are assembled in parallel.Where the battery is flowingcurrent and voltage constantly so as not to happen overcharging.The circuit is controlled automatically using theArduino nano and is monitored via LCD.
RESISTÊNCIA À COMPRESSÃO DE PASTAS CIMENTÍCIAS COMPOSTAS COM PÓS RECICLADOS DE RCD
Authors: Oliveira Dayana Ruth Bola , Leite Gabriela , Possan Edna , Marques Filho José
Published: January 2023

Estudo do pó reciclado de resíduo de construção e demolição (RCD) como material cimentício suplementar (MCS) ao cimento Portland comum (OPC) como uma alternativa para redução do consumo de aglomerante e à problemática da disposição de resíduos oriundos da Construção Civil. O objetivo da pesquisa foi avaliar a resistência à compressão de pastas compostas com teores de 0%, 7%, 15%, 20% e 25% de pó reciclado de RCD em substituição ao OPC, em volume. Os resíduos foram cominuídos em moinho de mandíbulas e peneirados até a fração <0,15mm, dando origem ao pó reciclado de concreto (RCP), pó reciclado misto (RMP) e pó reciclado cerâmico (RBP). A caracterização dos materiais foi realizada por massa específica, finura Blaine e granulometria a laser. O potencial pozolânico dos resíduos foi avaliado. Os resultados indicam que embora os pós de RCD não atendam os parâmetros normativos para classificação como materiais pozolânicos, estes auxiliam no incremento do desempenho mecânico de matrizes cimentícias compostas, a longo prazo. A resistência à compressão das pastas com até 20% de RCD como fíler atinge desempenho equivalente ou superior em relação à referência, cimento Portland composto com fíler – CPII – F 32 (FPC), com potencial de mitigar na mesma proporção o teor de ligante. O incremento mais expressivo de desempenho mecânico foi em pastas compostas com RCP aos 91 dias. O estudo indicou ainda que empregar pó reciclado de concreto e pó reciclado misto apresenta estatisticamente o mesmo efeito.
PLATAFORMIZAÇÃO, DESIGULDADE E PRECARIZAÇÃO DO TRABALHO: PERSPECTIVAS DAS POLÍTICAS PÚBLICAS NO BRASIL CONTEMPORÂNEO
Authors: Amaral Aluydio Bessa , Ferreira Eduardo Mohana Silva , Da Silva Enaire de Maria Sousa , Scriviner Neto José Samuel , Garcez Railson Marques
Published: January 2023

O trabalho em plataformas digitais tem crescido em todo o mundo trazendo em seu processo de disseminação muitas discussões e reflexões quanto ao seu modus operandi e rebatimentos para os trabalhadores “parceiros”. Assume-se a hipótese de que a plataformização atualiza o cenário de informalidade, precarização e desigualdade do mercado de trabalho no capitalismo contemporâneo, e é por considerar isso que buscou-se analisar, a partir de um estudo metodológico teórico-bibliográfico, com abordagem exploratória e qualitativa, a ascensão da plataformização e sua relação com a intensificação do trabalho e atualização da precarização do trabalhador considerando a dinâmica do gerenciamento algorítmico realizado pelas plataformas digitais de trabalho. Conclui-se que a dominação e exploração do trabalho neste século encontra terreno fértil no discurso e práticas neoliberais, na atuação despótica dos apps e na inércia Estatal em regular as plataformas e proteger os trabalhadores da exploração e escravidão plataformizada.
INTRODUÇÃO À HISTÓRIA URBANA POTIGUAR: EPÍTOME SOBRE NATAL E PARNAMIRIM
Authors: Fernandes Lenita Maria dos Santos
Published: January 2023

Este artigo possui como objetivo analisar a condição de formação social e a econômica da cidade de Natal e Parnamirim no Rio Grande do Norte. Para isso, utilizamos como fundamentação de pesquisa o materialismo histórico dialético e como metodologia uma pesquisa básica, qualitativa de caráter documental e bibliográfico a partir das obras História do Rio Grande do Norte e A História de Parnamirim e pesquisa quantitativa sobre a habitação e as atividades econômicas desenvolvidas através de dados do Atlas do Desenvolvimento Humano no Brasil e do Observatório de Trabalho Decente nos Municípios. Esses meios possibilitaram os seguintes resultados: conhecimento da estrutura social e econômica de formação social das cidades de Natal e Parnamirim no Rio Grande do Norte e setores econômicos atuais.
A ORDEM ECONÔMICA CONSTITUCIONAL BRASILEIRA À LUZ DA TEORIA DO DESENVOLVIMENTO COMO LIBERDADE
Authors: Sousa Mônica Teresa Costa , De Miranda Netto Edson Barbosa , de Miranda Sara Barros Pereira
Published: January 2023

Este artigo objetiva analisar a estrutura da ordem econômica constitucional brasileira inaugurada com a Constituição Federal de 1988 a partir da teoria do desenvolvimento como liberdade de Amartya Sen. Com relação à metodologia empregada, o presente artigo adotou a revisão sistemática. Verifica-se que a sua teoria discorda de visões limitadoras da atuação do Estado em uma livre economia de mercado, sendo fundamental a garantia das liberdades substantivas dos cidadãos. Por fim, constatou-se que o desenho institucional da ordem econômica brasileira almeja a construção de uma ampla rede protetiva e busca o desenvolvimento nacional não apenas sob o viés econômico.
ESTRUTURA E VIABILIDADE DO TREINAMENTO FÍSICO ATRAVÉS DA CONSULTORIA ONLINE
Authors: Da Silva Tayná Cristina Fernandes , Touguinha Henrique Menezes , Ribeiro-Silva Patrick Costa , Figueiredo Alan Peloso , Marins Fernanda Ribeiro , Lazo-Osorio Rodrigo Alexis , Rabello Luis Gustavo , Barbosa Erondina Leal
Published: January 2023

Com a pandemia da Covid-19, o isolamento social e a preocupação pela saúde a busca por profissionais que ofereçam um treinamento físico efetivo sem o acompanhamento presencial, evidencia a preocupação com a integridade do cliente. O objetivo deste artigo é, através de uma pesquisa de revisão bibliográfica em textos científicos, evidenciar pontos imprescindíveis na estrutura de um treinamento físico feito por meio de uma consultoria online e demarcar o quanto este tipo de serviço pode ser efetivo. Pôde-se constatar que o treinamento à distância é viável para um público específico, e que são necessários vários tipos de avaliação para determinar a condição do cliente e acompanhar sua progressão, tornando o treinamento mais seguro.
Estudio fenológico de Cinchona pubescens Vahl. en dos ecosistemas forestales, Intag, Imbabura
Authors: Cué García Jorge Luis , Ramírez-López Jorge , Changoluisa-Tumbaco Cristian , Quilismal-Paguay Miguel , Vallejos-Álvarez Hugo , Paredes-Rodríguez Hugo , Carrión-Burgos Andrés
Published: January 2023

La fenología es uno de los aspectos ecológicos principales cuando de manejo silvicultural y agroforestal se trata. Sin embargo, el conocimiento fenológico de especies forestales sigue siendo escaso y fragmentado, principalmente en los trópicos. Cinchona pubescens Vahl. presenta información fenológica limitada, por lo que se planteó el objetivo evaluar la fenología de la especie C. pubescens Vahl. en dos ecosistemas forestales (sistema silvopastoril y bosque secundario) ubicados en Pucará Alto, zona de Intag, Imbabura, por el periodo comprendido de abril 2018 – mayo 2020. Se caracterizaron y seleccionaron individuos de C. pubescens según características fenotípicas. El seguimiento fenológico se realizó con método semicualitativo de Fournier. Se calculó el Índice promedio (IP) y porcentaje ponderado de las fenofases. La foliación estuvo presente durante todo el año de manera intensa en los dos ecosistemas. La floración ocurrió una vez en el año, en el periodo enero-mayo en ambos ecosistemas con una masividad intensa. La fructificación para sistema silvopastoril ocurrió intensa en el periodo agosto-noviembre con su máximo en octubre y para bosque secundario con masividad media en el periodo septiembre-diciembre con su máximo en noviembre.
Effects of Various Social Media on Users’ Intercultural Communication Competence in Saudi Arabia
Authors: Abed Lowai
Published: January 2023

Intercultural communications have been transformed in recent years, largely due to the proliferation of social media applications. People from different countries and diverse cultures are now able to communicate with each other digitally, using multiple web-based communication platforms that have rapidly become an integral part of people’s daily lives. Thus, the effects of social media use on the intercultural communication competence (ICC) of individuals has attracted the attention of many scholars. This study examines, in a Saudi Arabian context, the extent to which different social media applications affect users’ ICC. The study is based on quantitative research methods, namely an online questionnaire to which 267 users responded. The study aims to explore participants’ perceptions of the effects of different social media applications on their own ICC, taking into account various demographic factors such as the age, gender, and level of education attained by each participant. In addition, the study investigates which social media applications are most common in Saudi Arabia, and which have the greatest influence on users’ ICC. The study’s findings show that while WhatsApp is the most commonly used social media application in Saudi Arabia, Twitter is perceived to have the greatest effect on users’ ICC.
A Study on the Phased Change in Political Participation of Chinese Citizen
Authors:   Center for Civic Politics Research, Chen Hong , Park Sang Do
Published: January 2023

Political participation has an important significance in political democracy and national governance in modern society which is also the basic operating system of modern democracy. Chinese citizens' political participation has always emphasized the concept of democracy in terms of not laying the foundation of the socialist political system.
However, previous studies analyze the political participation of Chinese citizens in terms of institutional and case studies, not in macro-level. Therefore, this study examines the time-series changes and current status of Chinese citizen political participation at a macro level.
The early form of Chinese civic political participation was mobilization-type political participation, which was an important driving force to break away from the feudal era and maintain a stable state system in the early days of the modern China. The next form that emerged is participation in various 'movement' dimensions reflecting the times when economic development was prioritized with independent civic political participation at a limited level. In the third stage, the form of government-led political participation appeared intensively after the 2000s, and at the same time, it was a process of more democratic political reform and institutionalization of citizens' political participation. The last stage is political participation in China's policy criticism, which is expanding based on ICT. A new form of political participation is emerging around online networked opinion leaders, which will establish itself as a basic participation method for generations living in the smart era in the future.
Based on this analysis, the paper is concluded by presenting suggestions and limitations for the sound development of Chinese civic politics.
Mathematical Modelling on the effect of Mercury on the Growth Rate of Serratia marcescens strain DRY6 on Sodium Dodecyl Sulphate
Authors: Abubakar Aisami , Yakasai Hafeez Muhammad
Published: January 2023

Sodium dodecyl sulfate (SDS) or sodium lauryl sulfate (SLS) is a common anionic surfactant found in various cleaning and personal hygiene products. It has both a polar "headgroup" and a hydrocarbon tail, giving it amphiphilic properties that make it effective as a detergent. However, this also makes it a major pollutant in aquatic environments. Researchers have studied the biodegradation of SDS by microorganisms, particularly bacteria, as a potential cleanup method. It has been found that mercury can significantly inhibit the degradation of SDS by the Serratia marcescens strain DRY6 bacteria. At different mercury concentrations, the bacteria exhibited sigmoidal growth with lag times of 7 to 10 hours, but overall growth was decreased with higher mercury concentrations, with a concentration of 1.0 g/L virtually stopping all growth. A modified Gompertz model was used to calculate growth rates at various mercury concentrations, and these rates were then modeled using five different models: modified Han-Levenspiel, Wang, Liu, modified Andrews, and Amor. Only three of the models (Wang, modified Han-Levenspiel, and Liu) were able to accurately fit the curve, with the Wang model performing the best statistically. The Wang model yielded estimates of 0.216 (95% confidence interval: 0.193 to 0.239) for the critical heavy metal ion concentration, 1.05 (95% confidence interval: 0.938 to 1.167) for the maximum growth rate, and 0.389 (95% confidence interval: 0.148 to 0.636) for the empirical constant , represented by Ccrit, max and m, respectively.
FOREST FIRE ANALYSIS USING MACHINE LEARNING
Authors: VARSHNEY CHIRAG , TUSHAR TUSHAR , Goel Dr.Amita , Sengar Er.Nidhi , Bahl Dr. Vasudha
Published: January 2023

Forest fires have become a major threat worldwide, causing many negative impacts on human habitats and forest ecosystems. Climate change and the greenhouse effect are some of the consequences of this destruction. Interestingly, the rate of forest fires occurring due to human activities is higher. Therefore, in order to minimize the devastation caused by forest fires, it is necessary to detect forest fires at an early stage. This paper proposes a system and method that can be used to detect forest fires at an early stage using a CNN model. Detecting smoke and fire is a difficult task, because variations in color and texture are so whimsical. Many smoke and fire image classification methods have been proposed to overcome this problem, but most of them are rule-based methods where accuracy is lower or homemade methods are expensive to produce. In this paper, we propose a new fire detection system using convolutional neural network. Fire detection using machine learning. It can be extremely difficult to detect fire and smoke with sensors already installed in buildings. They are slow and unprofitable due to their rudimentary design and technology. To solve this problem caused by training the network on a limited dataset, we improve the number of training images available using traditional techniques of data usage and enhancement.
TINGKAT PENGETAHUAN IBU TENTANG PENANGANAN DEMAM PADA ANAK DI APOTEK SEHAT SUKOHARJO
Authors: Puspitosari Adik , Hartono Hartono
Published: January 2023

ABSTRAK

Demam adalah tanda tubuh sedang melawan infeksi atau bakteri yang membuatnya sakit. Penanganan demam pada anak tergantung pada peran orang tua terutama ibu, sehingga diperlukan pengetahuan dalam menangani demam. Tingkat pengetahuan ibu sangat bervariasi sehingga terdapat perbedaan penanganan demam pada anak. Penelitian ini bertujuan untuk mengetahui gambaran tingkat pengetahuan ibu tentang penanganan demam pada anak di Apotek Sehat Sukoharjo. Jenis penelitian ini deskriptif, dengan metode yang digunakan adalah purposive sampling. Pengumpulan data dilakukan dengan menggunakan kuesioner dengan sampel 140 orang responden. Hasil penelitian menunjukkan responden mempunyai pengetahuan baik tentang definisi demam, mekanisme demam, penyebab demam, pengukuran suhu, obat demam, dosis obat, dan penyimpanan obat. Hampir semua responden (91%) belum memahami bahwa tidak semua demam merupakan keadaan berbahaya sehingga harus segera diturunkan dan akan terus meningkat jika tidak segera diturunkan dan terdapat 66% ibu masih salah dalam penggunaan kompres air dingin untuk menurunkan demam anak. Berdasarkan keseluruhan penelitian maka dapat disimpulkan bahwa gambaran tingkat pengetahuan ibu tentang penanganan demam pada anak di Apotek Sehat Sukoharjo dinyatakan baik sebesar 51,4% (72 orang) dan 45,7% (64 orang) memiliki pengetahuan yang cukup tentang penanganan damam pada anak, sedangkan pengetahuan yang kurang sebesar 2,9% (4 orang)

 

Kata Kunci: anak, demam, pengetahuan ibu.
HUBUNGAN PENGETAHUAN DAN PERSEPSI MASYARAKAT TERHADAP PENERIMAAN VAKSIN COVID- 19 DI DESA CISANTANA TAHUN 2021
Authors: Lisnawati Lilis , Azizah Nur
Published: January 2023

Persepsi masyarakat terhadap vaksin Covid-19 merupakan suatu tanggapan atau penerimaan dari informasi yang diperoleh mengenai keyakinan terhadap kehalalan vaksin, kesediaan divaksinasi dan kapasitas tenaga kesehatan yang memberikan vaksin Covid-19. Hal tersebut dikarenakan banyak sekali isu-isu yang mempengaruhi tentang informasi mengenai vaksin Covid-19 seperti faktor kehalalan dan keamanan dari vaksin Covid-19. Penelitian ini bertujuan untuk mengetahui persepsi masyarakat terhadap vaksin Covid-19 di Desa Cisantana. Penelitian ini merupakan penelitian kuantitatif dengan menggunakan desain cross sectional. Pada penelitian ini berjumlah 97 sampel yang diperoleh dari wawancara langsung serta pengisian kuisioner. Analisis data menggunakan Chi Square.

Berdasarkan hasil analisis maka dapat diketahui terdapat hubungan antara pengetahuan dan persepsi masyarakat dengan penerimaan vaksin Covid-19  di Desa Cisantana dengan p value 0,000 dan 0,002.
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Authors:   贵州省务川县实验学校, 王 若仲
Published: January 2023

本文基于如下数学问题来导入研究：数学问题1：对于平面上两两位置互不相同的n点(n≥3)，必对应存在一常数kn(kn≥1)，在连接任意两点而得到的全体线段中，至少有两条线段使得一条线段与另一条线段的比值不小于kn。数学问题2：对于空间中两两位置互不相同的n点(n≥4)，必对应存在一常数kn(kn≥1)，在连接任意两点而得到的全体线段中，至少有两条线段使得一条线段与另一条线段的比值不小于kn。先抛开这两个数学问题，本文发现基于平面上两两位置互不相同的n点(n≥3)或者空间中两两位置互不相同的n点(n≥4)，可以发掘出一些有趣的现象，本文对这些有趣的现象进行归纳，总结，整理出一套系统的理论，统称为点阵论。所谓点阵论即关于平面上两两位置互不相同的n点(n≥3)或者空间中两两位置互不相同的n点(n≥4)，所表现出来的某些性质特征。这些性质特征统称为点阵论。本文对点阵论进行描述和讨论相关的数学定理。
Reviewer Acknowledgements for International Education Studies, Vol. 16, No. 1
Authors: Lee Chris
Published: January 2023

Reviewer acknowledgements for International Education Studies, Vol. 16, No. 1, 2023.
Advances in Squamous Cell Carcinoma Antigen and Cervix Cancer Relationship
Authors:   Department for Gynecology, Obstetrics and Reproductive Medicine, Saarland University Hospital, 66421 Hamburg, Germany, bashar.hajhamoud@uks.eu, Hamoud Bashar H. , Georgescu Dragoș E. ,   "“Carol Davila” University of Medicine and Pharmacy, Department of Surgery, 020021, Bucharest, Romania; gfdragos@yahoo.com  “Dr. Ion Cantacuzino” Clinical Hospital, Department of Surgery, 030167, Bucharest, Romania", Călinoiu Amalia L. ,   “Prof Dr. Agrippa Ionescu” Emergency Clinical Hospital, Internal Medicine Clinic, Bucharest, Romania; acalinoiu@gmail.com, Văcăroiu Ileana A. ,   "“Carol Davila” University of Medicine and Pharmacy, Department of Nephrology, 020021, Bucharest, Romania; ileana.vacaroiu@umfcd.ro; “Sfantul Ioan” Clinical Emergency Hospital, Department of Nephrology, 042122, Bucharest, Romania", Georgescu Mihai T. ,   "“Carol Davila” University of Medicine and Pharmacy, Discipline of Oncology, Department 8, 020021, Bucharest, Romania; mihai.georgescu@umfcd.ro  “Prof. Dr. Al. Trestioreanu” Institute of Oncology, Department of Radiotherapy, 022328, Bucharest, Romania"
Published: January 2023

The squamous cell carcinoma antigen is a tumor marker that is receiving more interest due to its biological properties and importance in both pathological and normal physiological processes. Numerous clinical studies have been conducted to determine the potential function of squamous cell carcinoma antigen and its isoform complexes in clinical practice. These studies have been prompted by the fact that not only squamous cell carcinoma antigen but also circulating immune complexes of it and immunoglobulin M are involved in normal physiological and pathological processes. The therapeutic use of squamous cell carcinoma antigen as a tumor marker for either squamous carcinoma diagnosis or for monitoring the response to radiation or chemotherapy, tumor recurrence, and treatment failure are supported by prior investigations. The diagnostic or prognostic utility of squamous cell carcinoma antigen is debatable, nevertheless, as these investigations provide conflicting findings. A uniform detection method, scoring system, and cutoff level must be devised to limit clinical variability between studies and to provide a more accurate and trustworthy comparison of data. Additionally, even if the effectiveness of several approaches is equivalent, only one method should be used for the dynamic monitoring of tumor marker kinetics.
Concise Review on Modulation Mechanism of Matrix Metalloproteinase via Oncoviruses in Aggressiveness of Malignancies
Authors:   Applied Microbiology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran, Ramezani Ali ,   ramezaniali73@gmail.com (AR), ali.mirh@gmail.com (SAM), Behboodi Emad ,   Department of Microbiology, Golestan University of Medical Sciences, Gorgan, Iran; behboodi_emad@gmail.com, Mirhosseini Seyed A. ,   Applied Microbiology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran; ramezaniali73@gmail.com (AR), ali.mirh@gmail.com (SAM), Hashemzadeh Mohammad S. ,   Nanobiotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran; msh.biotechnology@gmail.com
Published: January 2023

"Matrix metalloproteinases (MMPs) are a member of the protein family intimately associated with zinc-containing endopeptidases, which are the main proteases implicated in extracellular matrix (ECM) degradation. The high ability of MMPs in the degradation of extracellular proteins is an important event in many normal biological as well as pathologic processes, including tumor progression, tissue repair, wound healing, developmental morphogenesis, and inflammatory diseases. This review is focused on the description of the modulation mechanism of MMPs via oncoviruses. Up to now, a large number of oncogenic viruses have been detected and recognized as etiologic factors of multiple human cancers. Actually, by expression of several viral oncoproteins of tumorigenic viruses with the simple genetic system, we are able to deregulate or modulate the pathways of cell transformation procedure in malignancy. In brief, upregulated expression of MMPs genes by direct (through DNA binding) , as well as indirect interactions (by activating PI-3K/AKT, ERK/MAPK, IFN/JAK/STAT, JNK, NF-κB signaling pathways and/or immune response) with tumorigenic viruses, have a noticeable role in the proliferation of cells, as well as angiogenesis, mobility, EMT, invasiveness, and metastatic features. In fact, the growth of tumor-related researchers offers a future perspective for the efficiency of targeted, molecular-based therapies and its anticancer effects via diverse mechanisms such as the suppression of viral oncoproteins. "
Diagnosis of Chronic Kidney Disease in the Elderly – A Challenge for the Practitioner
Authors:   Department of Nephrology, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, Rădulescu Daniela , Perde Filip ,   Mina Minovici National Institute of Legal Medicine, Bucharest, Romania, David Cristiana ,   Department of Nephrology, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, Lupuşoru Gabriela E. ,   Department of Nephrology, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, Lupuşoru Mircea O.D. ,   Discipline of Physiology, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, Tulin Florentina R. ,   "Department of Embryology, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania   Department of Endocrinology, Prof. Dr. Agrippa Ionescu Clinical Emergency Hospital, Bucharest, Romania", Ionescu Dorin ,   "Discipline of Internal Medicine I and Nephrology, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania ", Călinoiu Amalia L. ,   "Department of Internal Medicine, Prof. Dr. Agrippa Ionescu Clinical Emergency Hospital, Bucharest ", Isac Sebastian ,   "Discipline of Physiology, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania Department of Anesthesiology and Intensive Care 1, Fundeni Clinical Institute, Bucharest, Romania", Văcăroiu Ileana A. ,   Department of Nephrology, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Published: January 2023

"The recent increase in life expectancy is the main argument for a better understanding of the pathophysiological mechanisms underlying aging. These, once known, can provide possible links to therapies to prevent aging or slow down the process. Normal aging is associated with a progressive decrease in the glomerular filtration rate. Accurate estimation of GFR in the elderly is under the suspicion of multiple errors mainly due to sarcopenia and decreased protein intake. Differentiation between chronic kidney disease and the physiological decline of GFR might be a challenge in clinical practice and this has consequences on the evolution and treatment of the numerous comorbidities of the elderly. The current trend to use non-invasive diagnostic techniques explains the need to identify a serological marker to help differentiate between decreased GFR secondary to kidney aging or the development of chronic kidney disease."
Is Still Neurology Desirable as a Specialty for Aspiring Physicians?
Authors:   Department of Neurology, Central Military Emergency University Hospital, Bucharest, Romania, Sîrbu Carmen A. , Mihai Alexandra C. ,   Department of Neurology, Central Military Emergency University Hospital, Bucharest, Romania, Pleșa Florentina C. ,   "Department of Neurology, Central Military Emergency University Hospital, Bucharest, Romania   Department of Preclinical Disciplines, Faculty of Medicine, Titu Maiorescu University, Bucharest, Romania", Vasile Titus M. ,   "Department of Neurology, Central Military Emergency University Hospital, Bucharest, Romania Clinical Neurosciences Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Bucharest, Romania", Caloianu Ionuț ,   Department of Neurology, Central Military Emergency University Hospital, Bucharest, Romania, Manole Aida M. ,   Department of Neurology, Central Military Emergency University Hospital, Bucharest, Romania, Tuță Sorin ,   "Clinical Neurosciences Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Bucharest, Romania Department of Neurology, National Institute of Neurology and Neurovascular Diseases, Bucharest, Romania"
Published: January 2023

"This article aims to highlight the burnout burden among neurologists and provide information on some of its causes and consequences. We report an original article that reviews our current understanding of burnout matter in the neurology field. The main search engine through which we performed extensive literature research was PubMed, Scopus, and Google Scholar. The following information was collected: triggers of burnout and factors that perpetuate it, major complaints, values, and goals that dictate how coaching with it. Physician burnout is an umbrella term characterized by symptoms determined by exposure to chronic workplace stressors. Simply put, it encompasses many dimensions: emotional exhaustion, feelings of cynism, detachment (depersonalization), and a sense of ineffectiveness at work (low personal accomplishment). Burnout is common among all medical specialties, but neurology ranks at the top of the list. Several identified factors continue to fuel this problem. Properly addressing them, rethinking practice, and implementing wise, modern strategies can make significant contributions to reducing it. Aside from the chronic harm to the physician, burnout puts at risk the healthcare community at many levels including patients, other professionals, finances, etc. This paper wants to emphasize that burnout in neurology should be regarded as a global crisis. Thus, some strategies are proposed "
Mongolian-Russian Border Cooperation: The Role of the Republic of Buryatia
Authors: Dashnyam Zolboo , Tsend Baatar
Published: January 2023

This study has focused on border regions relations and cooperation between the Mongolia and Buryatia. As a border region, Buryatia has a centuries-old history of economic, political, cultural and humanitarian relations with Mongolia.Our relations have been successfully developing in all areas, high-level reciprocal visits have become regular, and mutual trust has been expanding.
The Ideas On The Unity Of Islam Have Been Provided In The National Revolution In Indonesia(8.1945) - One Approach
Authors:   The Academy of Real Korean History, Bui Thi Anh Van , Jang Anyoung
Published: January 2023

In 1945, the Second World War entered its final stage - it was also a time for Indonesia and the peoples of Southeast Asia to stand up to fight for independence. All classes of Indonesian people - regardless of political affiliation, regardless of religion - had all gathered under the banner of Merdeka independence. contributed significantly to the victory of the 1945 August Revolution.
They had thoroughly and effectively applied the “Unification” view of Islam in the national liberation revolution.
Since there are many differences, even ideological contradictions between Islam and nationalism, the relationship between them has always been difficult and uncertain. In Indonesia, the confrontation between Islam and nationalism during the interwar period was evident in political debate and action. If that had not stopped, it would have created fundamental ideological disagreements, thereby adversely affecting the anti-colonial movement.
In the first half of the twentieth century, Islam was the predominant religion in Indonesia and its followers made great contributions to the struggle against colonialism. In August 1945, Japanese fascism - the only enemy of the people of Southeast Asia was completely defeated in the Asian battlefield. Seizing the “once in a thousand years” opportunity, under the leadership of the Indonesian National Party, the Muslims rose up with the Indonesian people and carried out the August Revolution successfully in 1945.
It can be seen that the August 1945 revolution in Indonesia fully converged patriotic forces in the same national front. The combination of all sectors, all followers of religions under the banner of independence “Merdeka” has been the main reason for the success of the Indonesian national liberation revolution. It can be affirmed that the force of “Unity in Diversity” (“Bhineka Tunggal Ika”) has created a peaceful path to ward uniting the revolutionary forces of Indonesia.
An Analysis of Racial Economic Disparity and the Law in the United States
Authors:   Korea Public Choice Association, Lee Yong-Shik
Published: January 2023

Over six decades have passed since the civil rights movement began in the mid-50s, but American society has not yet fully realized the promise of the civil rights movement, which at its core embodies the protection and promotion of equity and dignity of all people. Despite the historic improvements that accord the legal protection of equal rights among different races, genders, and ethnic groups, significant economic disparity among races persists. The Reverend Martin Luther King, Jr. declared, “Now our struggle is for genuine equality, which means economic equality.” However, the pursuit of economic equality has not been successful. Growing racial economic disparity creates serious social, economic, and political problems in American society and pulls America away from the ideals of the civil rights movement. Structural economic problems in the United States, such as persistent income and wealth disparities along racial lines have exacerbated inequality that divides the country. This challenge requires a fundamental paradigm change. Racial economic disparity can no longer be overcome solely by individual efforts and self-reliance. The federal government must address racial economic disparity by facilitating economic development for minorities in close cooperation and coordination with state and local governments, as well as the private sector. Before America can fully meet the objectives of the civil rights movement, this country must achieve successful economic development that bridges racial economic disparity.
Studi Penambahan Gardu Sisipan Tipe Tiang untuk Mengatasi Beban Lebih di PT PLN (PERSERO) Area Cianjur Rayon Mande
Authors: Setia Giri Angga , Setiawan Hadi Umar , Haz Fauzia , Taryana Een
Published: January 2023

In the distribution system, blackouts caused by excessive loads cause losses for both consumers and electricity providers. Based on this, it is necessary to analyze the addition of distribution substations using an accurate methodology so that when applied it can be a solution to the need for electrical energi. Several stages of the method are determining the specifications of each component, calculating the optimal capacity of each component, measuring the voltage value contained in the panel and the primary part of the transformer at the hook-up substation, and simulating using ETAP software. The cantol substation was chosen because field studies have been carried out according to load requirements. The results of the calculation analysis show that with the addition of insertion substations, the total power becomes 100 kVA. The measured load at night is 77.7 kVA and during the day is 67.5 kVA. This indicates that the loading is in the allowable standard range below 80%. The voltage increased to 0.9828 per unit from the previous condition where there was a voltage drop of 11%. So that the load needs are met on demand.
Vulneración de derechos y protección de datos personales en Ecuador. Caso de estudio: Empresa SmartSolutions.
Authors: Durán Ramírez María Fernanda , Zamora Vázquez Ana Fabiola
Published: January 2023

Fundamentos: Este estudio se enfocó en el análisis de la Ley de Protección de Datos Personales, en Ecuador, al identificarse vulneraciones dentro de la página web de la empresa SmartSolutions, donde un usuario comparte información de carácter personal a través de un foro perjudicando a otra persona sin conocimiento de la normativa vigente y las posibles sanciones, penalidades y responsables al cometer este tipo de actividad. Métodos: Revisión sistemática de artículos científicos consultando diferentes bases de datos científicas, con un rango de fechas de los últimos 10 años, en los idiomas español e inglés. Se incluyó literatura gris mediante búsqueda manual. No hay restricciones en cuanto al tipo y método de investigación, además, se revisaron los resúmenes y, en algunos casos, los artículos completos, considerando finalmente todos los artículos que contenían recomendaciones y análisis sobre la protección de datos personales y su legislación en diferentes países. Resultados: Se seleccionaron artículos referentes a protección de datos personales, identificación de casos sobre vulneración de derechos en plataformas digitales, y se realizó el análisis concreto de lo que sucede con respeto a la legislación de Ecuador. Conclusiones: Para determinar la responsabilidad de la Empresa SmartSolutions de acuerdo a la Ley Orgánica de Protección de Datos Personales en su Art. 5 literal 2, el responsable de la seguridad de los datos personales es el responsable del tratamiento, y una de sus obligaciones es implementar políticas de protección de datos, así lo menciona el Art. 47 literal 4 de la ley en mención, pero, si la empresa se encuentra domiciliada fuera de nuestro territorio, nuestra normativa no tendría efecto.