bluuebunny/crossref_metadata_2025 huggingface dataset:
Molecular Dissection of Phagocytosis by Proteomic Analysis in Entamoeba histolytica
Authors: Watanabe Natsuki , Nakada-Tsukui Kumiko , Nozaki Tomoyoshi
Published: February 2023

Entamoeba histolytica is the enteric protozoan parasite responsible for amebiasis. Trophozoites of E. histolytica ingest human cells in the intestine and other organs, which is the hallmark of its pathogenesis. Phagocytosis and trogocytosis are pivotal biological functions for its virulence and also contribute to the proliferation of nutrient uptake from the environment. We previously elucidated the role of a variety of proteins associated with phagocytosis and trogocytosis, including Rab small GTPases, Rab effectors, including retromer, phosphoinositide-binding proteins, lysosomal hydrolase receptors, protein kinases, and cytoskeletal proteins. However, a number of proteins involved in phagocytosis and trogocytosis remain to be identified, and mechanistic details of their involvement must be elucidated at the molecular level. To date, a number of studies in which a repertoire of proteins associated with phagosomes and potentially involved in phagocytosis have been conducted. In this review, we revisited all phagosome proteome studies we previously conducted in order to reiterate information on the proteome of phagosomes. We demonstrated the core set of constitutive phagosomal proteins and also the set of phagosomal proteins recruited only transiently or in condition-dependent fashions. The catalogs of phagosome proteomes resulting from such analyses can be a useful source of information for future mechanistic studies as well as for confirming or excluding a possibility of whether a protein of interest in various investigations is likely or is potentially involved in phagocytosis and phagosome biogenesis.
Multiple Genetic Loci Associated with Pug Dog Thoracolumbar Myelopathy
Authors: Brander Gustaf , Rohdin Cecilia , Bianchi Matteo , Bergvall Kerstin , Andersson Göran , Ljungvall Ingrid , Hultin Jäderlund Karin , Häggström Jens , Hedhammar Åke , Lindblad-Toh Kerstin , Tengvall Katarina
Published: February 2023

Pug dogs with thoracolumbar myelopathy (PDM) present with a specific clinical phenotype that includes progressive pelvic limb ataxia and paresis, commonly accompanied by incontinence. Vertebral column malformations and lesions, excessive scar tissue of the meninges, and central nervous system inflammation have been described. PDM has a late onset and affects more male than female dogs. The breed-specific presentation of the disorder suggests that genetic risk factors are involved in the disease development. To perform a genome-wide search for PDM-associated loci, we applied a Bayesian model adapted for mapping complex traits (BayesR) and a cross-population extended haplotype homozygosity test (XP-EHH) in 51 affected and 38 control pugs. Nineteen associated loci (harboring 67 genes in total, including 34 potential candidate genes) and three candidate regions under selection (with four genes within or next to the signal) were identified. The multiple candidate genes identified have implicated functions in bone homeostasis, fibrotic scar tissue, inflammatory responses, or the formation, regulation, and differentiation of cartilage, suggesting the potential relevance of these processes to the pathogenesis of PDM.
PCIer: Pavement Condition Evaluation Using Aerial Imagery and Deep Learning
Authors: Han Sisi , Chung In-Hun , Jiang Yuhan , Uwakweh Benjamin
Published: February 2023

This paper aims to explore and evaluate aerial imagery and deep learning technology in pavement condition evaluation. A convolutional neural network (CNN) model, named PCIer, was designed to process aerial images and produce pavement condition index (PCI) estimations, which are classified into four scales of Good (PCI ≥ 70), Fair (50 ≤ PCI < 70), Poor (25 ≤ PCI < 50), and Very Poor (PCI < 25). In the experiment, the PCI datasets were retrieved from the published pavement condition report by the City of Sacramento, CA. Following the retrieved datasets, the authors also collected the corresponding aerial image datasets containing 100 images for each PCI grade from Google Earth. An 80% proportion of datasets were used for PCIer model training, and the remaining were used for testing. Comparisons showed using a 128-channel heatmap layer in the proposed PCIer model and saving the PCIer model with the best validation accuracy would yield the best performance, with a testing accuracy of 0.97, and a weighted average precision, recall, and F1-score of 0.98, 0.97, and 0.97, respectively. Moreover, future research recommendations are provided in the discussion for improving the effectiveness of pavement evaluation via aerial imagery and deep learning.
Columbia River Rhyolites: Age-Distribution Patterns and Their Implications for Arrival, Location, and Dispersion of Continental Flood Basalt Magmas in the Crust
Authors: Streck Martin J. , Swenton Vanessa M. , McIntosh William , Ferns Mark L. , Heizler Matt
Published: February 2023

Columbia River province magmatism is now known to include abundant and widespread rhyolite centers even though the view that the earliest rhyolites erupted from the McDermitt Caldera and other nearby volcanic fields along the Oregon–Nevada state border has persisted. Our study covers little-studied or unknown rhyolite occurrences in eastern Oregon that show a much wider distribution of older centers. With our new data on distribution of rhyolite centers and ages along with literature data, we consider rhyolites spanning from 17.5 to 14.5 Ma of eastern Oregon, northern Nevada, and western Idaho to be a direct response to flood basalts of the Columbia River Basalt Group (CRBG) and collectively categorize them as Columbia River Rhyolites. The age distribution patterns of Columbia River Rhyolites have implications for the arrival, location, and dispersion of flood basalt magmas in the crust. We consider the period from 17.5 to 16.4 Ma to be the waxing phase of rhyolite activity and the period from 15.3 to 14.5 Ma to be the waning phase. The largest number of centers was active between 16.3–15.4 Ma. The existence of crustal CRBG magma reservoirs beneath rhyolites seems inevitable, and hence, rhyolites suggest the following. The locations of centers of the waxing phase imply the arrival of CRBG magmas across the distribution area of rhyolites and are thought to correspond to the thermal pulses of arriving Picture Gorge Basalt and Picture-Gorge-Basalt-like magmas of the Imnaha Basalt in the north and to those of Steens Basalt magmas in the south. The earlier main rhyolite activity phase corresponds with Grande Ronde Basalt and evolved Picture Gorge Basalt and Steens Basalt. The later main phase rhyolite activity slightly postdated these basalts but is contemporaneous with icelanditic magmas that evolved from flood basalts. Similarly, centers of the waning phase span the area distribution of earlier phases and are similarly contemporaneous with icelanditic magmas and with other local basalts. These data have a number of implications for long-held notions about flood basalt migration through time and the age-progressive Snake River Plain Yellowstone rhyolite trend. There is no age progression in rhyolite activity from south-to-north, and this places doubt on the postulated south-to-north progression in basalt activity, at least for main-phase CRBG lavas. Furthermore, we suggest that age-progressive rhyolite activity of the Snake River Plain–Yellowstone trend starts at ~12 Ma with activity at the Bruneau Jarbidge center, and early centers along the Oregon–Nevada border, such as McDermitt, belong to the early to main phase rhyolites identified here.
Movement Behaviour and Health Outcomes in Rural Children: A Systematic Review
Authors: Vieira Douglas , Gomes Elenir Campelo , Negrão Ângelo Solano , Thuany Mabliny , Gomes Thayse Natacha
Published: February 2023

Background: Studies with rural children are limited, and results are divergent regarding the information on movement behaviours. Purpose: to (i) describe the physical activity and sedentary behaviour in children; (ii) synthetize the year and place of publication, methodological quality, and instruments used to measure physical activity and sedentary behaviour; and (iii) to analyse the relationship between physical activity, sedentary behaviour, and health outcomes in these children. Methods: We use the databases PubMed, Web of Science, SPORTDiscus, Scopus, Virtual Health Library, and SciELO, considering papers published until October 2021. A total of 12,196 studies were identified, and after the exclusion of duplicate, title and abstract screening, and the full-text assessment, a total of 68 were included in the study. Results: A cross-sectional design was dominant among the studies, with sample sizes ranging from 23 to 44,631 children of both sexes. One-third of the studies were conducted in North America and Europe, and most of them used device-based measurements. Inequalities were observed regarding sex, age, economic level, race, and physical activity domains within and between the places of residence. Sociodemographic characteristics were also related to health outcomes for children living in rural and urban areas. Conclusion: It is necessary to increase the evidence on movement behaviours among children living in the countries of South America and Oceania, as well as to increase the level of evidence on the role of school for physical activity in children in rural areas, given the inconsistent findings.
Enamel Analysis by 3D Scanning after Three Orthodontic Clean-Up Procedures: An In-Vitro Test of a New Piezoelectric Tool
Authors: Nardi Gianna Maria , Mazur Marta , Grassi Roberta , Rifuggiato Serena , Stiuso Vito , Janiszewska-Olszowska Joanna , Ottolenghi Livia , Barbato Ersilia , Minetola Paolo , Iuliano Luca
Published: February 2023

(1) Background: To assess the clinical safety and efficacy of a new piezoelectric instrument for orthodontic clean-up; (2) Methods: An in-vitro comparative study on 75 teeth extracted for orthodontic reasons compared the tested method (Treatment 1) with two other procedures: One step finisher and polisher (Inverted cone One gloss Shofu Dental, Kyoto, Japan) (Treatment 2) and twelve-fluted tungsten carbide bur (123-603-00, Dentaurum, Pforzheim, Germany) and Sof-Lex discs Pop-On XT Kit (3M ESPE) (Treatment 3), with n:25 samples in each group. Clinical safety (enamel volume loss) and effectiveness (residual adhesive volume) were assessed using the structured light 3D scanner Atos Compact Scan (GOM GmbH) together with the support of Atos Professional software. The surfaces were scanned three times to assess: (i) the volume of the residual adhesive (RAV) after bracket removal; (ii) the volume of the relative residual adhesive (dAV) after the clean-up procedure; (iii) volume of the enamel loss (EVL); (3) Results: The mean RAV (mm3) was 0.239 ± 0.337; 0.069 ± 0.124, 0.120 ± 0.193 and the mean EVL (mm3) was 0.1870 ± 0.177, 0.187 ± 0.299 and 0.290 ± 0.205, for treatment 1, 2 and 3, respectively. The distribution was asymmetrical between groups in both cases; (4) Conclusions: The tested instrument proved to be effective and safe for post-orthodontic clean-up. With the increasing use of invisible aligners, the possibility of using an ergonomic and fast instrument is of benefit to both patient and practitioner.
Race and Ethnic Differences in the Protective Effect of Parental Educational Attainment on Subsequent Perceived Tobacco Norms among US Youth
Authors: Adinkrah Edward , Najand Babak , Young-Brinn Angela
Published: February 2023

Background: Although parental educational attainment is known to be associated with a lower prevalence of behaviors such as tobacco use, these effects are shown to be weaker for Black than White youth. It is important to study whether this difference is due to higher perceived tobacco use norms for Black youth. Aim: To study the association between parental educational attainment and perceived tobacco use norms overall and by race/ethnicity among youth in the US. Methods: The current study used four years of follow-up data from the Population Assessment of Tobacco and Health (PATH-Youth) study conducted between 2013 and 2017. All participants were 12- to 17-year-old non-smokers at baseline and were successfully followed for four years (n = 4329). The outcome of interest was perceived tobacco use norms risk at year four. The predictor of interest was baseline parental educational attainment, the moderator was race/ethnicity, and the covariates were age, sex, and parental marital status at baseline. Results: Our linear regressions in the pooled sample showed that higher parental educational attainment at baseline was predictive of perceived disapproval of tobacco use at year four; however, this association was weaker for Latino than non-Latino youth. Our stratified models also showed that higher parental educational attainment was associated with perceived tobacco use norms for non-Latino but not for Latino youth. Conclusion: The effect of high parental educational attainment on anti-tobacco norms differs between Latino and non-Latino youth. Latino youth with highly educated parents remain at risk of tobacco use, while non-Latino youth with highly educated parents show low susceptibility to tobacco use.
Trace Metal(loid) Migration from Road Dust to Local Vegetables and Tree Tissues and the Bioaccessibility-Based Health Risk: Impacts of Vehicle Operation-Associated Emissions
Authors: Liu Guangbo , Chen Tian , Cui Jinli , Zhao Yanping , Li Zhi , Liang Weixin , Sun Jianteng , Liu Zhenghui , Xiao Tangfu
Published: February 2023

Traffic activities release large amounts of trace metal(loid)s in urban environments. However, the impact of vehicle operation-associated emissions on trace metal(loid) enrichment in road dust and the potential migration of these trace metal(loid)s to the surrounding environment remain unclear. We evaluated the contamination, sequential fraction, and bioaccessibility of trace metal(loid)s in urban environments by assessing their presence in road dust, garden vegetables, and tree tissues, including bark and aerial roots, at a traffic-training venue impacted by vehicle operation emissions and, finally, calculated the bioaccessibility-based health risk. The results indicated a significant accumulation of trace metal(loid)s in road dust, with the highest lead (Pb), cadmium (Cd), and antimony (Sb) concentrations in the garage entrance area due to higher vehicle volumes, frequent vehicle starts and stops, and lower speeds. Aerial roots exposed to hill start conditions exhibited the highest Pb, Zn, and Sb levels, potentially caused by high road dust resuspension, confirming that this tree tissue is an appropriate bioindicator. Sequential extraction revealed high percentages of carbonate-, Fe/Mn oxide-, and organic/sulphide-associated fractions of Pb, copper (Cu), and zinc (Zn) in road dust, while most Cd, Cr, Ni, and Sb occurred as residual fractions. According to the potential mobilizable fractions in sequential extraction, the in vitro gastrointestinal method could be more suitable than the physiologically based extraction test to evaluate the bioaccessibility-related risk of traffic-impacted road dust. The bioaccessibility-based health risk assessment of the road dust or soil confirmed no concern about noncarcinogenic risk, while the major risk originated from Pb although leaded gasoline was prohibited before the venue establishment. Furthermore, the cancer risks (CRs) analysis showed the probable occurrence of carcinogenic health effects from Cd and Ni to adults and from Cd, Cr, and Ni to children. Furthermore, the Cd and Pb concentrations in the edible leaves of cabbage and radish growing in gardens were higher than the recommended maximum value. This study focused on the health risks of road dust directly impacted by vehicle emissions and provides accurate predictions of trace metal(loid) contamination sources in the urban environment.
Immunopathological Assessment of the Oral Mucosa in Dermatitis Herpetiformis
Authors: Mania-Końsko Agnieszka , Szponar Elżbieta , Dańczak-Pazdrowska Aleksandra , Bowszyc-Dmochowska Monika , Pazdrowski Jakub , Wyganowska Marzena
Published: February 2023

Dermatitis herpetiformis (Duhring’s disease, DH) is a chronic blistering cutaneous condition with pruritic polymorphic lesions, consisting of vesicles, papules or nodules and erythema, found predominantly on the extensor surfaces of the limbs, buttocks, and neck. Diagnosis is based on characteristic clinical and immunopathological findings. Oral manifestations of DH have rarely been described. The aim of the study was to evaluate IgA, IgG, IgM and C3 complement deposits in the oral mucosa in DH patients. Direct immunofluorescence (DIF) was performed on the oral mucosa specimens collected from 10 DH patients. Biopsy was taken in a local anesthesia from perilesional site from the buccal mucosa and then preserved in a standard procedure using polyclonal rabbit IgG, IgA, IgM and C3 antibodies. Granular IgA and C3 deposits were found in 6 patients (60%), and in 3 subjects (30%) the result was indeterminate. Significant fluorescence of the deposits along the basement membrane was observed in 2 patients, moderate fluorescence in 3 patients, and in 4 cases the result was indeterminate. C3 deposits were found in 5 subjects (50%), 3 of them being moderate and 2 indeterminate. No IgM and IgG deposits were detected in the collected buccal mucosa specimens.
Multi-Source Data Fusion and Hydrodynamics for Urban Waterlogging Risk Identification
Authors: Zhang Zongjia , Zeng Yiping , Huang Zhejun , Liu Junguo , Yang Lili
Published: February 2023

The complex formation mechanism and numerous influencing factors of urban waterlogging disasters make the identification of their risk an essential matter. This paper proposes a framework for identifying urban waterlogging risk that combines multi-source data fusion with hydrodynamics (MDF-H). The framework consists of a source data layer, a model parameter layer, and a calculation layer. Using multi-source data fusion technology, we processed urban meteorological information, geographic information, and municipal engineering information in a unified computation-oriented manner to form a deep fusion of a globalized multi-data layer. In conjunction with the hydrological analysis results, the irregular sub-catchment regions are divided and utilized as calculating containers for the localized runoff yield and flow concentration. Four categories of source data, meteorological data, topographic data, urban underlying surface data, and municipal and traffic data, with a total of 12 factors, are considered the model input variables to define a real-time and comprehensive runoff coefficient. The computational layer consists of three calculating levels: total study area, sub-catchment, and grid. The surface runoff inter-regional connectivity is realized at all levels of the urban road network when combined with hydrodynamic theory. A two-level drainage capacity assessment model is proposed based on the drainage pipe volume density. The final result is the extent and depth of waterlogging in the study area, and a real-time waterlogging distribution map is formed. It demonstrates a mathematical study and an effective simulation of the horizontal transition of rainfall into the surface runoff in a large-scale urban area. The proposed method was validated by the sudden rainstorm event in Futian District, Shenzhen, on 11 April 2019. The average accuracy for identifying waterlogging depth was greater than 95%. The MDF-H framework has the advantages of precise prediction, rapid calculation speed, and wide applicability to large-scale regions.
Novel Mutations in MPT64 Secretory Protein of Mycobacterium tuberculosis Complex
Authors: Muhammad Noor , Khan Muhammad Tahir , Ali Sajid , Khan Taj Ali , Khan Anwar Sheed , Ullah Nadeem , Higazi Hassan , Ali Sara , Mohamed Salma , Qasim Muhammad
Published: February 2023

Tuberculosis (TB) is a global health problem caused by the Mycobacterium tuberculosis complex (MTBC). These bacteria secrete various proteins involved in the pathogenesis and persistence of MTBC. Among the secretory proteins, MPT64 (Rv1980C) is highly conserved and is also known as a major culture filtrate that is used in rapid diagnosis of MTBC. In the current study, we aimed to find the mutation in this highly conserved protein in isolates from the Pashtun-dominant province of Pakistan. We analyzed 470 M. tuberculosis whole-genome sequences of Khyber Pakhtunkhwa Province. Mutations in the MPT64 gene were screened through TB-Profiler and BioEdit software tools. The DynaMut web server was used to analyze the impact of the mutation on protein dynamics and stability. Among 470 MTB genomes, three non-synonymous mutations were detected in nine isolates, and one synonymous mutation (G208A) was found in four isolates. Mutation G211T (F159L), which was detected at the C-terminal domain of the protein in six isolates, was the most prominent. The second novel mutation, T480C (I70V), was detected in two isolates at the C-terminal side of the protein structure. The third novel mutation, A491C (L66R), was detected in a single isolate at the N-terminal side of the MPT64 protein. The effect of these three mutations was destabilizing on the protein structure. The molecular flexibility of the first two mutations increased, and the last one decreased. MPT64 is a highly conserved secretory protein, harboring only a few mutations. This study provides useful information for better managing the diagnosis of MTB isolates in high TB-burden countries.
Smoke Exposure Reduces the Protective Effect of Physical Activity on Hypertension: Evidence from the National Health and Nutrition Examination Survey (NHANES) 2013–2018
Authors: Li Chen , Wang Yiyi , Wang Shouyu , Huang Lei
Published: February 2023

The joint effects between smoke exposure (SE) and physical activity (PA) on hypertension are still unclear, and the effect of SE is still debated. To explore associations and joint effects of SE and PA on hypertension, the data of 14,456 selected participants from the NHANES (2013–2018) were used for analyses. SE status was divided by serum cotinine concentrations. Moderate-to-vigorous intensity PA (MVPA) and insufficient or no PA (INPA) were divided by the Global Physical Activity Questionnaire. Hypertension was assessed by blood pressure and questionnaires. Survey logistic multivariable regression models were conducted for data analyses. In fully adjusted models, hypertension risk among SE participants increased (OR = 1.175, 95% CI: 1.036–1.332), especially those who were <40 years or female. However, the risk among MVPA participants decreased (OR = 0.747, 95% CI: 0.663–0.841), especially those who were ≥40 years. Additionally, the OR for MVPA participants without SE when compared with INPA ones without SE was 0.740 (95% CI: 0.654–0.837), especially those who were <60 years. However, the OR for MVPA participants with SE was 0.880 (95% CI: 0.747–1.037). For INPA participants, we did not observe significant ORs for SE compared with non-SE participants (p > 0.150). In conclusion, SE increased the risk of hypertension and MVPA reduced it, but SE could reduce such protective effect.
Decreased Respiratory-Related Absenteeism among Preschool Students after Installation of Upper Room Germicidal Ultraviolet Light: Analysis of Newly Discovered Historical Data
Authors: Ryan Christopher W.
Published: February 2023

The COVID-19 pandemic has brought renewed urgency to air disinfection. Upper room germicidal ultraviolet light (GUV) disinfects room air very efficiently. Its effect on practical outcomes in public settings remains unclear, but history may provide some insights. An interrupted time series model was fitted to a newly discovered dataset of attendance records from a preschool between 1941 to 1949, where GUV was installed in December 1945. GUV was associated with a sizable reduction in child absenteeism due to respiratory illnesses of any cause. Odds ratios for the effect ranged from 0.5 to 0.77, depending on the season. In all but high summer, model-predicted absenteeism rates were reduced by between a third and a half by GUV. Wider use of upper room germicidal UV systems in schools and preschools may be worthwhile, to reduce absenteeism due to respiratory illness and the educational, social, and economic consequences that ensue.
Evaluation and Optimization of Cultural Perception of Coastal Greenway Landscape Based on Structural Equation Model
Authors: Yang Yili , Chen Yuxing , Liu Yueyan , He Tianyou , Chen Lingyan
Published: February 2023

The island-type greenway should emphasize the role of maintaining and promoting the island cultural landscape as it serves the function of a general greenway green infrastructure while also having a unique landscape appearance. The northern greenway of Pingtan is used as an example in the paper to illustrate how regional culture is perceived. The first part of the analysis looks at how demographic factors affect the quality of cultural perception. The study reveals that: from a gender perspective, women are more likely than men to perceive regional culture; from an age perspective, people between the ages of 18 and 40 are more likely to perceive regional culture; older people and children are less likely to perceive regional culture; and from a level of education perspective, the higher the education, the stronger the perception. The relationship between tourists’ perceived quality, cognitive image, perceived value, satisfaction, and loyalty to the cultural expression of the greenway landscape is then analyzed by building a structural equation model. According to the findings, visitors’ perceptions of the island’s cultural quality have a positive impact on their cognitive images and perceptions of value, while their satisfaction with the cultural expressions along the coastal greenway has a positive impact on their loyalty.
Birth Outcomes in DES Children and Grandchildren: A Multigenerational National Cohort Study on Informative Families
Authors: Gaspari Laura , Soyer-Gobillard Marie-Odile , Rincheval Nathalie , Paris Françoise , Kalfa Nicolas , Hamamah Samir , Sultan Charles
Published: February 2023

Objective: Diethylstilbestrol (DES), a potent synthetic nonsteroidal estrogen belonging to the family of endocrine disrupting chemicals (EDCs), can cross the placenta and may cause permanent adverse health effects in the exposed mothers, their children (exposed in utero), and also their grandchildren through germline contribution to the zygote. This study evaluated pregnancy duration and birthweight (BW) variations in the children and grandchildren born before, during, and after maternal DES treatment in the same informative families, to rule out genetic, endocrine, and environmental factors. Design and setting: Nationwide retrospective observational study on 529 families of DES-treated women registered at the HHORAGES-France Association. The inclusion criteria were: (i) women with at least three pregnancies and three viable children among whom the first was not exposed in utero to DES, followed by one or more children with fetal exposure to DES, and then by one or more children born after DES treatment; (ii) women with at least one pre-DES or post-DES grandchild and one DES grandchild; (iii) confirmed data on total DES dose. Women with severe pathologies or whose illness status, habitat, lifestyle habits, profession, treatment changed between pregnancies, and all mothers who reported pregnancy-related problems, were excluded. Results: In all, 74 women met all criteria. The preterm birth (PTB) rate was 2.7% in pre-DES, 14.9% in DES, and 10.8% in post-DES children (Cochran-Armitage test for trend, p = 0.0095). The mean BW was higher in DES than pre-DES full-term neonates (≥37 weeks of gestation) (p = 0.007). In grandchildren, BW was not different, whereas the PTB and low BW rates were slightly increased in children of DES women. Conclusions: These data within the same informative families show the DES impact on BW and PTB in DES and post-DES children and grandchildren. In particular, mean BW was higher in DES than pre-DES full-term neonates. This result may be in opposition to previous data from American cohorts, which reported lower BW in DES children, but is consistent with animal study. Our retrospective observational study highlights a multigenerational and likely transgenerational effect of this EDC in humans.
Assessment of Physical Tests in 6–11 Years Old Children: Findings from the Play Lifestyle and Activity in Youth (PLAY) Study
Authors: Sugimoto Dai , Stracciolini Andrea , Berbert Laura , Nohelty Eric , Kobelski Greggory P. , Parmeter Becky , Weller Edie , Faigenbaum Avery D. , Myer Gregory D.
Published: February 2023

The purpose was to evaluate selected physical tests in children and to compare the outcomes by sex. A cross-sectional study design was used to evaluate children 6–11 years who completed five physical tests: hand grip, vertical jump, sit and reach, Y-balance, and obstacle course (time and score). The outcome measures including test results were descriptively examined and compared by sex. The study participants consisted of 133 children (62 males and 71 females, with a median age of 7.8 years). Girls showed superior sit and reach performance (p = 0.002) compared with boys. Boys demonstrated better Y-balance scores (p = 0.007) and faster obstacle time (p = 0.042) than girls. Sex comparison within three age groups (6–<8 years, 8–<10 years, and 10–<12 years) showed that girls performed better on the sit and reach compared with boys in the in 6–<8 years (p = 0.009). Boys demonstrated higher Y-balance scores (p = 0.017) and faster obstacle time (p = 0.007) compared with girls in the 8–<10-year age group. These data will serve to guide future efforts to evaluate normative measures of physical literacy and guide targeted training interventions to promote sustained physical activity in children with deficits relative to their age and sex norms.
Age-Friendly Community Interventions for Health and Social Outcomes: A Scoping Review
Authors: Hong Andy , Welch-Stockton Jessie , Kim Ja Young , Canham Sarah L. , Greer Valerie , Sorweid Michelle
Published: February 2023

To address the numerous challenges associated with aging, increased attention has been given to the development of age-friendly cities and communities (AFCC) to promote healthy aging and social participation. However, limited evidence exists for addressing both health and social needs through the AFCC framework. We address this gap by conducting a scoping review of the interventions that target both health and social outcomes within the purview of the AFCC framework. The results showed that many of the successful interventions used a partnership model and behavioral change theories to inform the program design and implementation. The results also indicated that social participation and engagement played a key role in making the interventions successful. However, the results revealed that the literature is dominated by person-focused approaches. Future research should focus more on evaluating environmental-focused interventions and develop a holistic framework that combines both person- and environment-based approaches to healthy aging.
The Legal Guarantee for Achieving Carbon Peak and Neutrality Goals in China
Authors: Shi Hui , He Xiaobin
Published: February 2023

In order to actively fulfill its international treaty obligations, China has established the goal of peaking CO2 emissions by 2030 and achieving carbon neutrality by 2060. Since 2018, when ecological civilization was written into the Constitution, the realization of carbon peak and neutrality goals has had an ideological foundation and a constitutional basis. China has formulated various special laws and built a 1 + N policy system to reduce carbon emissions, which together with the environmental protection law, climate change law, energy law and other related laws and regulations constitute a unified legal system and provide legal support to achieve carbon peak and neutrality goals. At the same time, China has taken advantage of the new national system with concentrated efforts and resources to delineate the different roles of the government and market mechanisms in carbon emission reduction, and to make the operation of the legal system of carbon peak and neutrality suitable for its actual situation by giving full paly to the initiative of both central and local governments. This article analyzes the current legal system and its characteristics in China in the process of achieving carbon peak and neutrality goals in the context of the new era, and outlooks on the improvement path of the legal system from both domestic and international dimensions. The practice, experience and development direction of China in the construction of the legal guarantee for carbon peak and neutrality goals can provide reference for other countries to achieve carbon reduction.
Valorization of Sargassum Biomass as Potential Material for the Remediation of Heavy-Metals-Contaminated Waters
Authors: González Fernández Lázaro Adrián , Navarro Frómeta Amado Enrique , Carranza Álvarez Candy , Flores Ramírez Rogelio , Díaz Flores Paola Elizabeth , Castillo Ramos Ventura , Sánchez Polo Manuel , Carrasco Marín Francisco , Medellín Castillo Nahum Andrés
Published: February 2023

Sargassum algae has become a major environmental issue due to its abundance in the Pacific Ocean with hundreds of tons reaching the beaches of the Mexican Caribbean every year. This generates large quantities of decomposing organic matter that have a negative impact on the region’s economy and ecosystems. Sargassum valorization has turned out to be a fundamental aspect to mitigate its environmental impact. This study proposes the use and application of untreated Sargassum biomass for the decontamination of waters polluted with lead (Pb) and cadmium (Cd) through single and binary adsorption tests. Physicochemical and textural properties examined by SEM, XRD, and FT-IR elucidated that Sargassum biomass is viable to be used as a potential environmental benign adsorbent, exhibiting Cd(II) and Pb(II) adsorption capacities as high as 240 mg g−1 and 350 mg g−1, respectively, outperforming conventionally used adsorbents. This is attributed to its morphology, favorable surface charge distribution, and the presence of -OH and -COH groups. A strong affinity between the biomass and metal pollutants was evidenced by a thermodynamics study, showing a spontaneous and endothermic process. This work sets a practical route for the utilization of the Sargassum biomass, demonstrating its applicability as a potential material for heavy-metal-polluted water remediation, making a substantial contribution to a circular economy system.
Models of Support for Caregivers and Patients with the Post-COVID-19 Condition: A Scoping Review
Authors: Cavalcante Tahissa , Lourenço Caroline , Ferreira José , Oliveira Lídia , Neto João , Amaro Josemberg , Moreira Rafaella
Published: February 2023

Background: In December 2019, an outbreak of the coronavirus disease 2019 (COVID-19), caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), occurred in the city of Wuhan, China. On 30 January 2020, the World Health Organization declared the outbreak a public health emergency of international concern. In October 2021, with the advancement of the disease, the World Health Organization defined the post-COVID-19 condition. The post-COVID-19 condition occurs in individuals with a history of probable or confirmed infection with SARS-CoV-2, usually 3 months after the onset of the disease. The chronicity of COVID-19 has increased the importance of recognizing caregivers and their needs. Methods: We conducted a scoping review following international guidelines to map the models of support for caregivers and patients with the post-COVID-19 condition. The searches were conducted in electronic databases and the grey literature. The Population, Concept, and Context framework was used: Population: patients with the post-COVID-19 condition and caregivers; Concept: models of caregiver and patient support; and Context: post-COVID-19 condition. A total of 3258 records were identified through the electronic search, and 20 articles were included in the final sample. Results: The studies approached existing guidelines and health policies for post-COVID-19 condition patients and support services for patients and home caregivers such as telerehabilitation, multidisciplinary care, hybrid models of care, and follow-up services. Only one study specifically addressed the home caregivers of patients with this clinical condition. Conclusions: The review indicates that strategies such as telerehabilitation are effective for training and monitoring the patient–family dyad, but the conditions of access and digital literacy must be considered.
Family Resilience Progress from the Perspective of Parents of Adolescents with Depression: An Interpretative Phenomenological Analysis
Authors: Zhang Yinying , Huang Chongmei , Yang Min
Published: February 2023

Family resilience plays an important role in the healthy family development of adolescents with depression, but few studies have explored the specific process of family resilience. This study aims to explore the dynamic processes of family resilience from parents of adolescents with depression. Data were collected from 14 Chinese parents of adolescents with depression by interpretative phenomenological analysis method. Four themes and 12 sub-themes emerged: (1) decompensation phase: (i) misinterpretations of illness, (ii) heavy psychological burden, (iii) chaotic rhythms in family; (2) launch phase: (i) potential influences of labeling, (ii) we must cure my child anyway, (iii) begin adjusting to family roles; (3) recovery phase: (i) family reflection, (ii) subsequent reorganization of family resources, (iii) ultimately establishing a new balance; (4) normality phase: (i) adaption for medical seeking process, (ii) actively lower expectations, (iii) concerns of future needs. Mental health professionals could provide targeted suggestions to help the parents achieve family resilience by assessing its different phases.
Relation between VT1, VT2, and VO2max with the Special Wrestling Fitness Test in Youth Wrestlers: A Short Report
Authors: Herrera-Valenzuela Tomás , Franchini Emerson , Valdés-Badilla Pablo , Ojeda-Aravena Alex , Pardo-Tamayo Carolina , Zapata-Huenullán Carolina , Cofre-Bolados Cristián , Sanchez-Ramirez Celso
Published: February 2023

This study investigated the relationship between peak oxygen uptake and ventilatory threshold 1 (VT1) and 2 (VT2) with the Special Wrestling Fitness Test variables. Thirteen wrestlers (male: six; female: seven) of Olympic freestyle wrestling were assessed. The Pearson’s correlation coefficient (p < 0.05) was used to establish the relationship between variables. A positive correlation was found between VT1 with throws in set B (r = 0.77; p = 0.002; 95%CI = 0.37–0.93), total throws (r = 0.73; p = 0.004; 95%CI = 0.30–0.91), heart rate recovery (r = 0.58; p = 0.036; 95%CI = 0.05–0.86), and test index (r = −0.60; p = 0.031; 95%CI = −0.86–0.07); between VT2 and throws in set B (r = 0.57; p = 0.043; 95%CI = 0.01–0.86); and between peak oxygen uptake with throws in set B (r = 0.77; p = 0.002; 95%CI = 0.39–0.93), throws in set C (r = 0.64; p = 0.02; 95%CI = 0.12–0.89), and total throws (r = 0.72; p = 0.006; 95%CI = 0.28–0.91). In conclusion, the peak oxygen uptake and ventilatory thresholds correlated with specific Special Wrestling Fitness Test variables.
Validation of the Arabic Version of the Edmonton Symptom Assessment System
Authors: Shamieh Omar , Alarjeh Ghadeer , Qadire Mohammad Al , Amin Zaid , AlHawamdeh Abdelrahman , Al-Omari Mohammad , Mohtadi Omar , Illeyyan Abdullah , Ayaad Omar , Al-Ajarmeh Sawsan , Al-Tabba Amal , Ammar Khawlah , Al-Rimawi Dalia , Abu-Nasser Mahmoud , Abu Farsakh Fadi , Hui David
Published: February 2023

Quality cancer care is a team effort. In addition, patients’ symptoms change over the course of treatment. As such, the Edmonton Symptom Assessment System (ESAS) is a simple tool designed to quickly monitor symptom change. Here, we present the results from a two-phase study aimed at validating the Arabic version of the ESAS (ESAS-A). Phase one involved the creation of two versions of the ESAS with both reverse and forward translations by bilingual, native Arabic speakers as well as evaluation by an expert panel. The reconciled version was then administered to 20 patients as a pilot from which to create the final version, which was then used with 244 patients. Phase two for the ESAS—involved an ESAS-based validation of 244 adults aged 18 years and older who were diagnosed with advanced cancer; then, further validation was completed in conjunction with two other symptom survey tools, the EORTC-Pal 15 and the HADS. The ESAS-A items possessed good internal consistency with an average Cronbach’s alpha of 0.84, ranging from 0.82 to 0.85. Moreover, the results of ESAS-A showed good agreement with those of EORTC QLQ- 15 PAL (r = 0.36 to 0.69) and HADS (r = 0.60 and 0.57) regarding anxiety and depression. We found the ESAS-A to be responsive to symptom change and a median time to completion of 3.73 min. The results of our study demonstrate that the ESAS-A is a reliable, valid, and feasible tool for the purposes of monitoring symptom change over the course of cancer treatment.
The Relationship between Childcare-Giving Arrangements and Children’s Malnutrition Status in South Africa
Authors: Sello Matshidiso , Adedini Sunday A. , Odimegwu Clifford , Petlele Rebaone , Tapera Talent
Published: February 2023

Multiple caregiving arrangements have become common for childcare globally, and South Africa is no exception. Previous childcare studies mainly focused on the caregiver and household characteristics. Evidence on the influence of childcare on malnutrition is sparse. This study aimed to examine the relationship between exposure to secondary and multiple forms of care and child malnutrition, with a particular focus on child stunting and overweight among children. A cross-sectional study of a sample of 2966 dyads of mothers and children under five were analysed from the 2017 National Income Dynamics Study (NIDS) Wave 5. Descriptive and inferential statistics were used to analyse the data. The results indicated that 22.16% of the children were stunted and that 16.40% were overweight. Most children were mainly cared for at home (67.16%) during the day. Some results of the obtained multivariable analyses show that lack of being cared for in a crèche or school during the day was significantly associated with stunting (odds ratio (OR) 2; confidence interval (CI) 1.10–3.62, p < 0.05) and overweight (OR) 3.82; (CI) 1.60–9.08, p < 0.05). Furthermore, in this study, 69.88% of children who were cared for at home by the primary caregiver had no other forms of multiple care arrangements. The results showing high stunting and overweight rates among children cared for at home suggest that the government needs to look into supporting caregiver parenting. The high unemployment rates in the country highlight the importance of socioeconomic status in childcare and its implication for children’s nutritional outcomes. The study’s findings suggest the need for innovative strategies to address the challenges associated with multi-caregiving which negatively affects children’s nutritional outcomes.
Changes in Sources and Composition of Beach Waste in Coastal Cities around the Bohai Sea of China during the Tourist Peak and Off-Peak Seasons
Authors: Kong Tianqi , Li Xuefei , Pan Ke , Zhang Wanli , Li Rundong
Published: February 2023

Beach waste is an important pollutant in the Bohai Sea and coastal cities around the Bohai Sea and has raised many social and environmental concerns in China. The semi-closed characteristics of the Bohai Sea, the well-developed tourism, the special industrial structure and residents’ living habits endow the beach waste around Bohai sea with a unique character that should be explored. This study investigated changes in the sources and composition of beach waste in coastal cities around the Bohai Sea of China during the tourist peak and off-peak seasons. Beach waste from twenty beaches in thirteen coastal cities around the Bohai Sea was sampled and analyzed in March and August 2021, respectively. The results showed that beach waste around the Bohai Sea was characterized by large quantities and small weights and was greatly affected by human coastal activities. The sources and composition of beach waste from different coasts and different seasons varied, whereas the overall trend was consistent. In terms of composition, beach waste in both the tourist peak season and off-peak season was mainly composed of plastics, fabrics and paper, which accounted for more than 70% of the total in weight. Meanwhile, the proportion of plastics in the total quantity of beach waste was greatest (maximum of up to 71%) and exhibited seasonal fluctuations, trending higher in the tourist peak season than in the off-peak season. In contrast, trends in the proportion of paper and fabrics in the total quantity and total weight of beach waste were relatively stable in different seasons. In terms of sources, beach waste mainly derived from human coastal activities, the proportion of which in the total quantity of beach waste in the tourist peak season reached 70.55% and was 11% higher than that in the tourist off-peak season. Shipping/fishing activities were the second largest source of beach waste, and their proportion in the total quantity of beach waste in the tourist peak season was 5% lower than that in the tourist off-peak season, as the tourist peak season around the Bohai Sea coincides exactly with the fishing moratorium. The quantity of smoking-related waste only accounted for 9.35% and 7.73% of beach waste in the tourist peak and off-peak seasons, respectively. The special semi-enclosed structure of the Bohai gulf, surrounded by land on three sides, aggravated the accumulation of beach waste on the coast. Source reduction and classified recovery, collaborative management of marine waste and beach waste, and joint prevention and control mechanisms of three provinces (Liaoning, Hebei and Shandong) and one municipality (Tianjin) were suggested for comprehensive management of beach waste in coastal cities around the Bohai Sea of China. This study provided valuable information for beach waste management in coastal cities around the Bohai Sea of China.
Conservation Practices for Personal Protective Equipment: A Systematic Review with Focus on Lower-Income Countries
Authors: Thiel Cassandra L. , Sreedhar Pallavi , Silva Genevieve S. , Greene Hannah C. , Seetharaman Meenakshi , Durr Meghan , Roberts Timothy , Vedanthan Rajesh , Lee Paul H. , Andrade Gizely , El-Shahawy Omar , Hochman Sarah E.
Published: February 2023

During the start of the COVID-19 pandemic, shortages of personal protective equipment (PPE) necessitated unprecedented and non-validated approaches to conserve PPE at healthcare facilities, especially in high income countries where single-use disposable PPE was ubiquitous. Our team conducted a systematic literature review to evaluate historic approaches for conserving single-use PPE, expecting that lower-income countries or developing contexts may already be uniquely conserving PPE. However, of the 50 included studies, only 3 originated from middle-income countries and none originated from low-income countries. Data from the included studies suggest PPE remained effective with extended use and with multiple or repeated use in clinical settings, as long as donning and doffing were performed in a standard manner. Multiple decontamination techniques were effective in disinfecting single use PPE for repeated use. These findings can inform healthcare facilities and providers in establishing protocols for safe conservation of PPE supplies and updating existing protocols to improve sustainability and overall resilience. Future studies should evaluate conservation practices in low-resource settings during non-pandemic times to develop strategies for more sustainable and resilient healthcare worldwide.