bluuebunny/crossref_metadata_2025 huggingface dataset:
Combined triple treatment of fibrin amyloid microclots and platelet pathology in individuals with Long COVID/ Post-Acute Sequelae of COVID-19 (PASC) can resolve their persistent symptoms
Authors: Pretorius Etheresia , Venter Chantelle , Laubscher Gert Jacobus , Kotze Maritha J. , Moremi Kelebogile , Oladejo Sunday , Watson Liam R. , Rajaratnam Kanshu , Watson Bruce W. , Kell Douglas B.
Published: December 2021

We recognise that fibrin(ogen) amyloid microclots and platelet hyperactivation, that we have previously observed in COVID-19 and Long COVID/Post-Acute Sequelae of COVID-19 (PASC) patients, might form a suitable set of foci for the clinical treatment of the symptoms of long COVID/PASC. We first report on the comorbidities and symptoms found in a cohort of 845 South African Long COVID/PASC patients who filled in the South African Long COVID/PASC registry, of which hypertension and high cholesterol levels (dyslipidaemia) were the most important comorbidities. The gender balance (70% female) and the most commonly reported Long COVID/PASC symptoms (fatigue, brain fog, loss of concentration and forgetfulness, shortness of breath, as well as joint and muscle pains) were comparable to those reported elsewhere. This suggests that our sample was not at all atypical. Using a previously published scoring system for fibrin amyloid microclots and platelet pathology, we analysed blood samples from 70 patients, and report the presence of significant fibrin amyloid microclots and platelet pathology in all cases; these were associated with Long COVID/PASC symptoms that persisted after the recovery from acute COVID-19. A subset of 24 patients was treated with one month of dual antiplatelet therapy (DAPT) (Clopidogrel 75mg/Aspirin 75mg) once a day, as well as a direct oral anticoagulant (DOAC) (Apixiban) 5 mg twice a day. A proton pump inhibitor (PPI) pantoprazole 40 mg/day was also prescribed for gastric protection. Such a regime must only be followed under strict and qualified medical guidance to obviate any dangers, especially haemorrhagic bleeding, and of the therapy as a whole. Thromboelastography (TEG®) was used to assist in determining their clotting status. Each of the 24 treated cases reported that their main symptoms were resolved and fatigue as the main symptom was relieved, and this was also reflected in a decrease of both the fibrin amyloid microclots and platelet pathology scores. Nine patients were genotyped for genetic variation in homocysteine metabolism implicated in hypertension, a common COVID-19 co-morbidity reported in both patients found to be homozygous for the risk-associated MTHFR 677 T-allele. Fibrin amyloid microclots that block capillaries and inhibit the transport of O2 to tissues, accompanied by platelet hyperactivation, provide a ready explanation for the symptoms of Long COVID/PASC. The removal and reversal of these underlying endotheliopathies provide an important treatment option that seems to be highly efficacious, and warrants controlled clinical studies.
Inhomogeneous spatial patterns in diffusive predator-prey system with spatial memory and predator-taxis
Authors: Lv Yehu
Published: December 2021

In this paper, we consider a diffusive predator-prey system with spatial memory and predator-taxis. Since in this system, the memory delay appears in the diffusion term, and the diffusion term is nonlinear, the classical normal form of Hopf bifurcation in the reaction-diffusion system with delay can't be applied to this system. Thus, in this paper, we first derive an algorithm for calculating the normal form of Hopf bifurcation in this system. Then in order to illustrate the effectiveness of our newly developed algorithm, we consider the diffusive Holling-Tanner model with spatial memory and predator-taxis. The stability and Hopf bifurcation analysis of this model are investigated, and the direction and stability of Hopf bifurcation periodic solution are also researched by using our newly developed algorithm for calculating the normal form of Hopf bifurcation. At last, we carry out some numerical simulations, two stable spatially inhomogeneous periodic solutions corresponding to the mode-1 and mode-2 Hopf bifurcations are found, which verifies our theoretical analysis results.
The Effect of Levetiracetam Treatment on Survival in Patients with Glioblastoma: A Systematic Review and Meta-Analysis.
Authors: Chen Jia-Shu , Clarke Ross , Haddad Alexander F. , Wang Elaina J. , Lacroix Michel , Sarkar Indra Neil , Zand Ramin , Chen Elizabeth S. , Toms Steven A.
Published: December 2021

Background:Levetiracetam (LEV) is an anti-epileptic drug (AED) that sensitizes glioblastoma (GBM) to temozolomide (TMZ) chemotherapy by inhibiting O6-methylguanine-DNA methyltransferase (MGMT) expression. Adding LEV to the standard of care (SOC) for GBM may improve TMZ efficacy. This study aimed to pool the existing evidence in the literature to quantify LEV’s effect on GBM survival and characterize its safety profile to determine whether incorporating LEV into the SOC is warranted.Method:A search of CINAHL, Embase, PubMed, and Web of Science from inception to May 2021 was performed to identify relevant articles. Hazard ratios (HR), median overall survival, and adverse events were pooled using random-effect models. Meta-regression, funnel plots, and the Newcastle-Ottawa Scale were utilized to identify sources of heterogeneity, bias, and statistical influence.Results:From 20 included studies, 5804 GBM patients underwent meta-analysis, of which 1923 (33%) were treated with LEV. Administration of LEV did not significantly improve survival in the entire patient population (HR=0.89, p=0.094). Significant heterogeneity was observed during pooling of HRs (I2=75%, p<0.01). Meta-regression determined that LEV treatment effect decreased with greater rates of MGMT methylation (RC=0.03, p=0.02) and increased with greater proportions of female patients (RC=-0.05, p=0.002). Concurrent LEV with the SOC for GBM did not increase odds of adverse events relative to other AEDs.Conclusions:Levetiracetam treatment may not be effective for all GBM patients. Instead, LEV may be better suited for treating specific molecular profiles of GBM. Further studies are necessary to identify optimal GBM candidates for LEV.
Spectral-Warping Based Noise-Robust Enhanced Children ASR System
Authors: Bawa Puneet , Kadyan Virender , Kumar Vaibhav , Raghuwanshi Ghanshyam
Published: December 2021

In real-life applications, noise originating from different sound sources modifies the characteristics of an input signal which affects the development of an enhanced ASR system. This contamination degrades the quality and comprehension of speech variables while impacting the performance of human-machine communication systems. This paper aims to minimise noise challenges by using a robust feature extraction methodology through introduction of an optimised filtering technique. Initially, the evaluations for enhancing input signals are constructed by using state transformation matrix and minimising a mean square error based upon the linear time variance techniques of Kalman and Adaptive Wiener Filtering. Consequently, Mel-frequency cepstral coefficients (MFCC), Linear Predictive Cepstral Coefficient (LPCC), RelAtive SpecTrAl-Perceptual Linear Prediction (RASTA-PLP) and Gammatone Frequency cepstral coefficient (GFCC) based feature extraction methods have been synthesised with their comparable efficiency in order to derive the adequate characteristics of a signal. It also handle the large-scale training complexities lies among the training and testing dataset. Consequently, the acoustic mismatch and linguistic complexity of large-scale variations lies within small set of speakers have been handle by utilising the Vocal Tract Length Normalization (VTLN) based warping of the test utterances. Furthermore, the spectral warping approach has been used by time reversing the samples inside a frame and passing them into the filter network corresponding to each frame. Finally, the overall Relative Improvement (RI) of 16.13% on 5-way perturbed spectral warped based noise augmented dataset through Wiener Filtering in comparison to other systems respectively.
Orthognathic surgery-first approach with lingual appliances: a case report
Authors: Pamukçu Hande , Özsoy Serhat , Tüz Hakan H. , Polat-Özsoy Ömur
Published: December 2021

Background

A surgery-first approach has many advantages related to a shortened treatment time and an immediate facial aesthetic improvement compared to a three-stage conventional orthognathic surgery protocol.

Objective

The aim of this case report was to describe the treatment of a 21-year-old, female, patient who presented with a skeletal Class III malocclusion, maxillary retrusion, a negative overjet, an anterior and bilateral posterior cross-bite, and a vertical facial pattern highlighted by a high mandibular plane angle.

Methods

Orthodontic treatment was performed using self-ligating lingual appliances and a surgery-first approach. The active treatment time was 16 months.

Results and conclusion

Successful treatment results were achieved using a combination of an orthognathic surgery-first approach and lingual appliances in a patient with high aesthetic expectations.
Innovative development of the management potential at a modern enterprise
Authors: Pysmak Viktoriia , Mazhnyk Lidiya , Sigaieva Tetiana
Published: December 2021

The development of the national economy and its components in modern conditions is increasingly dependent on technological shifts based on innovation. The ability to form and effectively use potential is becoming a decisive factor in enhancing the competitiveness and development of enterprises. The development of managerial capacity will allow enterprises to adapt quickly to new environmental conditions and make effective management decisions. With the transformation of the economic system towards social orientation, there is a transition from outdated forms of enterprise potential management to a new vision of the quality of management potential. Basic approaches to assessing the quality of management potential in its innovative development were formed. The main features of the innovative development of managerial potential were identified. The main features of the development of innovative management potential were determined. A basic structure for management potential innovative development measures was proposed, which regulates that a company’s policy in the field of improving the efficiency of management capacity is a subordinate element of the general strategy of an enterprise, but at the same time it is necessary to monitor the balance between economic performance and social justice.
Increasing resource efficiency in the industrial complex ensuring environmental human rights
Authors: Deineko Liudmyla , Sychevskiy Mykola , Tsyplitska Olena , Grebeniuk Nadiia , Deineko Oleksandr
Published: December 2021

The close relationship between industrial development and environmental pollution is considered the main problem of negative climate changes and the deterioration of life quality leading to an increase in mortality. In this regard, the protection of environmental human rights is of great importance. The paper aims to assess the trends of industrial influence on the human environment and the level of protection of environmental human rights in different countries through reviewing and analysis of the set of relevant studies. The paper brings novelty exploring an array of objectives for protecting human environmental rights in the framework of the Sustainable Development Goals, implementation of a circular and resource-efficient economy, together with the Industry 4.0 technologies for industrialized countries, including Ukraine. Most studies consider contradictions between the economic and environmental goals of both businesses and the state the main obstacle for the ecologization of industrial production. The economic feasibility of introducing more resource-efficient business models has been proved. The impact of Ukrainian industrial companies on the environment and the state of human environmental rights protection is studied. The results of the study allow stating that the resource and energy inefficiency of industrial technology in the country, as well as the weakness of state institutions in the implementation of reforms for sustainable development, is a fundamental threat to human rights and a healthy life.
Ambient dose equivalent rate and soil contamination density with 137Cs in kitchen gardens in settlements of the Bryansk region, Russia in 2020–2021
Authors: Ramzaev V. P. , Barkovsky A. N. , Bratilova A. A.
Published: December 2021

The article provides results of application of the field (in situ) gamma spectrometry method for carrying out mass monitoring measurements of ambient dose equivalent rate and soil contamination density with 137Cs in kitchen garden plots located in the zone of radioactive contamination after the Chernobyl accident. In 2020 and 2021, 115 private farmsteads in 46 settlements of the Bryansk region were surveyed. At the time of the survey, the officially established average density of soil contamination with 137Cs in the settlements ranged from 27 to 533 kBq/m2 . The field spectra were measured using a portable scintillation gamma-spectrometer-dosimeter. Results of the field measurements and subsequent calculations of soil contamination density with 137Cs in the kitchen gardens were in good agreement with official data on the average soil contamination density with 137Cs in the surveyed settlements. The mean value of the ratio of the experimental data to the official data was 1.04. Individual values of experimental data deviated from corresponding official values by no more than two times. The use of the gamma spectrometry method in situ made it possible: 1) to determine separately values of the ambient dose equivalent rate from 137Cs and from natural radionuclides in the soil, and 2) to estimate the effective external doses to a person who worked in the kitchen gardens. The measured values of ambient dose equivalent rate varied from 17 to 53 nSv/h (mean ± standard deviation = 35 ± 9 nSv/h) for natural radionuclides and from 8 to 432 nSv/h (mean ± standard deviation = 125 ± 91 nSv/h) for 137Cs. The ambient dose equivalent rate from 137Cs normalized to the soil contamination density with 137Cs in the same kitchen garden was in the range of 0.41–0.84 (nSv/h)/(kBq/m2 ) with a mean value of 0.55 (nSv/h)/(kBq/m2 ). If a person stayed in kitchen garden for 840 hours per year, the estimated effective external doses from natural radionuclides and 137Cs were respectively in the range of 0.008–0.025 mSv/year and 0.004–0.20 mSv/year.
The use of Hajj fund for investment purpose: a maqashid sharia approach
Authors: Muheramtohadi Singgih
Published: December 2021

Purpose -  Hajj financial use The Hajj is an obligation for Muslims who can carry out. Over time, the number of people who perform Hajj is increasing, but the quota is minimal. It raises new problems; one of them is the problem of the financial management of Hajj. The financial of Hajj accumulates and inflation occurs every year. One of the solutions to the financial problem in Hajj is to invest in a productive field. The purpose of this paper is to find out the Islamic scholars’ consideration of the justification of using Hajj fund and investing it in productive fields.Method - This research is conducted through a qualitative descriptive approach.Result - All Islamic organizations in Indonesia, especially MUI (Majelis Ulama Indonesia/ Indonesian Ulama Council), justify the Hajj financial use.Implication  -  The result can be used by society as information and consideration regarding Hajj and the mechanism of financial management in religious prayers administered by the government.Originality  - This research study the recent existence of investment purposes in Hajj fund management.
The role of public management in Hospital Social Responsibility (HSR) activities in building the image of Sunan Kudus Islamic Hospital
Authors: Lailyah Nurzahroh
Published: December 2021

Purpose – The purpose of this research is to understand the role of Public Relations Management in activities Hospital Social Responsibility (HSR) to improve image of Sunan Kudus Islamic Hospital. This study is also designed to understand the ability of Hospital Social Responsibility (HSR) in bringing benefits to the hospital Islam Sunan Kudus.Method – Primary data were obtained directly from observations and interviews with the Sunan Kudus Islamic Hospital, in this case the Public Relations Management and the community involved in HSR activities. The data analysis technique used several analyzes, namely descriptive, sociological, hostoris, and data validity.Result – The role of Public Relations in HSR activities can improve image of the Sunan Kudus Islamic Hospital, this is proven with the HSR activities carried out by RSI Sunan Kudus followed by all levels of society in the city Kudus so that through the HSR activity the name RSI Sunan Kudus is known to the wider community and ultimately society who is in the Kudus city to entrust his health to Sunan Kudus Islamic Hospital.Implication – This study can motivate other hospitals to implement HSR (Hospital Social Responsibility), so that a mutual symbiotic relationship can be created between the hospital and the community.Originality – In other studies only discussing CSR in general, there are no findings regarding HSR, and there is no CSR or HSR aspect in it Islamic perspective, apart from that there are no other benefits seen due to the existence of CSR in the hospital
The implementation of PSBB on the development of retail MSMEs with the COVID-19 pandemic as a moderating variable
Authors: Trihudiyatmanto M
Published: December 2021

Purpose – This study aims to analyse the effect of the implementation of PSBB on the development of Retail MSMEs (micro, small, and medium enterprises).Method – Respondents in the study were 100 respondents. The sampling technique used in this study was purposive sampling, with the criteria for Retail MSMEs actors in Garung District, Wonosobo Regency, and at least the business had been operating for one year. The data analysis technique used in this research was SEM Smart PLS.Result – The development of Retail MSMEs was significantly influenced by the implementation of PSBB and was moderated by the Covid-19 pandemic. Implication – This study can assist businesses and the government during a pandemic outbreak.Originality – This is the first study examining the influence of a pandemic outbreak on the development of MSMEs in the retail industry.
The implementation of good corporate governance at Baitut Tamwil Muhammadiyah (BTM) Tegal
Authors: Hidayat Arip
Published: December 2021

Purpose – Author studied the implementation of good corporate governance in a context of microfinance institution. Corporate Governance is a very strategic determining factor for the progress of a company in order to continuously increase value and maintain an ongoing and sustainable growth process.Method – Sources of data used in this study were taken from primary data and secondary data. Apart from interviews, other primary data source categories include reviewing, reading several global financial reports and standard operating procedure (SOP). Secondary data were obtained from books as a complement to primary data sources. Additional secondary data source of this research was obtained by conducting literature reviews.Result – Modern pondok of Tazakka uses at least six different waqf program as a financial source of their activities. These programmes are asset waqf, cash waqf, productive waqf, benefits waqf, profession waqf, and transfer of rights waqf. The programmes help the pondok to be more autonomous and able to provide various benefits for the scholars of the pondok and the people surround it. Implication – The results show that the Baitut Tamwil Muhammadiyah (BTM) implemented a good corporate governance.Originality – This study has enriched an empirical study of corporate governance in microfinance institution in Indonesia.
Waqf empowerment for the autonomy of Islamic boarding school (pesantren); study of modern Islamic boarding school (pondok) Tazakka Batang
Authors: Mahmassani Subhi
Published: December 2021

Purpose – This study aims to study waqf instrument developed by modern Islamic boarding school (pondok) Tazakka, Batang.Method – This study is a qualitative field research, which utilizes observation, interview, and documentation. The character of this research is descriptive analysis.Result – Modern pondok of Tazakka uses at least six different waqf program as a financial source of their activities. These programmes are asset waqf, cash waqf, productive waqf, benefits waqf, profession waqf, and transfer of rights waqf. The programmes help the pondok to be more autonomous and able to provide various benefits for the scholars of the pondok and the people surround it. Implication – This research gives illustration of waqf management in an Islamic boarding school. By understanding the mechanism of the waqf management, hopefully Islamic boarding schools in Indonesia able to empower themselves better.Originality – A lot of Islamic boarding schools use waqf for his research is among the few researchs which taking a perspective of empowering religious social organization in Indonesia.
Research of the thermal interface of LED lighting sources by thermal relaxation differential spectrometry (TRDS)
Authors: Aliakseyeu Yu , Bumai Yu , Vaskou A. , Niss V. , Vėžys J. , Minchenya V.
Published: December 2021

Thermal relaxation differential spectrometry (TRDS) was used to study the thermal parameters of samples with various design features for heat removal - a powerful LED lamp (150 W) used in industrial and street lighting, low power LED lamps (4 W) with filament emitters, as well as SMD emitter. It is shown that the method of thermal relaxation differential spectrometry is effectively applicable to the study of the structure of thermal parameters of both high-power and low-power LED devices. The method is informative and allows to study in the distribution of thermal resistance and heat flux over the volume and layers of the LED device detail. The use of the TRDS method allows the optimization of the thermal design of LED devices to reduce the overheating temperature of their active regions, and, therefore, to reduce the degradation of LED devices.
Kitsch ve Estetik
Authors: Karagüzel Rabia , Karaca Gülçin
Published: December 2021

Kitsch kavramının kökeni çok eski tarihlere dayalı olsa da gerçek varlığını ilk olarak 1800’lü yılların ikinci yarısından sonraki sanat piyasasında bulunan basit, gösterişli, kolayca pazarlanabilen, karşıt estetik değer ve klişe tarzdaki özellikleri içeren eserleri tanımlamak adına ortaya çıktığı gözlemlenebilir. Çok yönlü uygulanma alanına sahip olan kitschin geçmişten günümüze birçok sanatsal yaratı ve uygulamalarda var olduğu kabul edilebilir fakat kitsch olarak nitelenen görüntülerin anlamına yönelik tanımının bugün dahil bir kesinlik barındırmaması kitsch kavramını sanatsal yönlerden tartışmalara açık hale getirmektedir.

Bu araştırmanın amacı da çoğu zaman farkında olmadan üretilen, sanatın beklentileri karşısında yetersiz olarak değerlendirilebilen kitsch eserleri güzel ve çirkin kavramları arasındaki karşıtlık yönünden ele almak ve 21. Yüzyıldaki estetik anlayışla birlikte kitschin güncel sanat pratiklerinde farklı ve yaratıcı bir yöntem olarak da kullanılabilecek bir yönü olduğunu vurgulamaktır. Bu amaç doğrultusunda yöntem olarak döküman analizi uygulanmış ve konuyla ilişkili eser görselleri ek kaynak olarak değerlendirilmiştir. Araştırma Giriş; Kitsch; Güzel, Estetik ve Çirkin; Kitsch ve Estetik; Sonuç ve Öneriler olmak üzere 5 başlıktan oluşmaktadır.
Sonuç olarak güzel ve çirkinin çatışkısındaki kitsch kavramından yola çıkarak, kitschin sanatsal yönü incelenmiş ve bu alanda üretilen eserler için farklı gözlem ve ele alış biçimleri kaynaklarla birlikte değerlendirilmiştir. Böylelikle değişen estetik anlayışla birlikte kitschin tanımının da yeni anlamlara büründüğü vurgulanmak istenmiştir. Araştırmada kitsch kavramı sanatsal bir ifade biçimi olarak belirtilmiş ve bundan sonraki süreçte sanat alanında kitsche atfedilen değerleri tanımlayabilmek için araştırmanın yarar sağlayacağı düşünülmektedir.
Improving the dependability of light vented foundations exposed to vibration load on frost soils
Authors: Tyurin M. A. , Bocharov M. E. , Vorontsov V. A. , Melnikova A. V.
Published: December 2021

Aim. Today, dynamically-loaded foundations of process equipment often prove to be oversized with significantly overestimated values of stiffness, mass and material consumption. Therefore, reducing the costs and time of construction of gas pipeline facilities, especially on permafrost, is of relevance to PJSC Gazprom. One of the primary ways of solving this problem is installing gas pumping equipment on light vented support structures. The disadvantage of such structures is the low vibration rigidity. A method [1] is proposed for improving the vibration rigidity of a foundation subjected to vibration load. The simulation aims to improve the dependability of light vented foundations by studying vibration displacements of foundations with attached reinforced concrete panels depending on the thermal state of frost soils, parameters of the attached panels and connectors. Methods. Vibration displacements of a foundation with an attached device were identified using the finite element method and the improved computational model of the foundation – GCU – soil system. Results. Computational experiments identified the vibration displacements of the foundation in the cold and warm seasons for the following cases of reinforced concrete plates attached to the foundation: symmetrical and non-symmetrical; at different distances; through connectors with different stiffness parameters; with additional weights; frozen to the ground. Conclusions were made based on the results of simulation of vibration displacements of foundations with an attached device in cold and warm seasons. Conclusion. The presented results of computational experiments aimed at improving the vibration rigidity of light foundations by using method [1] show sufficiently good indicators of reduced vibration displacements of the foundation. Thus, in the case of symmetrical connection of four reinforced concrete panels in summer, the reduction of vibration displacements is 42.4%, while increased stiffness of the connectors, attachment of additional weights and freezing of reinforced concrete panels into the ground will allow reducing the vibration displacements of the foundation up to 2.5 times. However, it should be noted, that applying the findings in the process of development of project documentation and construction of foundations requires R&D activities involving verification and comparison of the obtained results of numerical simulation with a natural experiment.
Preserve it or not: civilizational identity in the context of globalization
Authors: Zazulina Mariya R.
Published: December 2021

The article was prepared as a part of the discussion “Russia and Siberia in the Eurasian socio-cultural space” and is devoted to understanding the problems raised in the work of A. V. Ivanov and Yu. V. Popkov “Spiritual and ecological civilizational perspective: the value potential of youth in the Siberian context”, which initiated this discussion. The aim of the article is to study the place of civilizational identity in the general coordinate system formed by multilevel identity, and in which way the value of civilizational identity as an independent sociocultural phenomenon changes under the influence of globalization processes. The novelty of the research is determined by the research attitude towards the comparative analysis of global and civilizational identities in modern conditions. The author’s view of the changes taking place with the idea of civilization under the influence of globalization, the logic of these processes, internal mechanisms and prospects for further development is proposed. It is shown that globalization initially serves as a trigger for the process of transformation of civilizational identity and sociocultural space in general and then continues to retain its influence as its significant factor. The result of cultural globalization is the formation of a global identity. As a result, global and civilizational identities find themselves in a state of competition, since in the modern system of values they represent two “neighboring” highest levels of identity, transnational in nature, and are largely determined by similar factors. The formation process features of civilizational identity in different conditions (Russia and Europe) are outlined. It is concluded that the general trend is its directed and conscious construction, accompanied by the politicization of this phenomenon. Meanwhile, the difference in the strategies for formation of civilizational identity in Russia and Europe is determined by the emerging relations between civilizational identity and the institution of the national state.
White Matter Microstructure is Associated with Serum Clusterin and
Everyday Functioning in a Sample of Nondemented Older Adults
Authors: Clark Alexandra L. , Solders Seraphina K. , Thomas Kelsey R. , Bangen Katherine J.
Published: December 2021

Background:

Although clusterin-a protein involved in lipid metabolism, amyloid beta
clearance, and myelination-has been linked to gray matter atrophy within samples of older adults at
risk for Alzheimer’s disease, research exploring associations with white matter (WM) micro- and
macro- structural markers are largely limited.

Objective::

The current study [1] explored associations between serum clusterin protein levels and
WM micro- and macro- structural markers, and [2] clarified whether variations in WM fractional
anisotropy (FA) were associated with functional abilities within in a racially homogenous sample
of relatively well-educated older adults free of dementia.

Methods:

Participants underwent magnetic resonance imaging (MRI) brain exams and a blood
draw and completed a performance-based measure of everyday functioning. Multiple linear regression
adjusting for age, sex, APOE e4 positivity, and vascular risk were used to explore serum clusterin
associations with WM metrics, as well clarify potential links between WM microstructure and
everyday functioning.

Results:

Higher serum clusterin was associated with lower FA in several thalamocortical (anterior
and posterior internal capsule, posterior thalamic radiation; ßs = -.32 to -.37, ps = .01 to .02) and association
fiber tracts (external capsule, superior longitudinal fasciculus; ßs = -.32 to -.40, ps = .02).
Serum clusterin was not associated with white matter hyperintensity volume (ß = .14, p = .28), but
higher FA of several WM tracts was associated with better performance on the Independent Living
Scale (ßs = .37 to .53, ps = .006 to .03).

Conclusion:

Serum clusterin is differentially associated with WM metrics, and WM microstructure
is associated with everyday functioning.
Animal Placental Therapy: An Emerging Tool for Health Care
Authors: Gupta Madhu , Mumtaz Sayed Md. , Goyal Ramesh K. , Ameen A. Najeerul , Alexandrovich Bazikov Igor
Published: December 2021

Background:

The placenta maintains and regulates the growth of fetus and consists of various biologically active nutrients such as cytomedines, vitamins, trace elements, amino acids, peptides, growth factors, and other biologically active constituents.

Introduction:

The therapeutic effectiveness of the placenta can be well defined with respect to several biochemical mechanisms of various components present in it. The placental extract derived from biomedical wastes has also shown a great potential for treatment of various diseases.

Method:

Placental therapy has been reported specifically to have potent action in the treatment of diseases and tissue regeneration.

Result:

Placental bioactive components and their multi-targeting identity prompted us to compile the précise information on placental extract products. However, some findings are needed to be explored by scientific community to prove their clinical potential with significant statistical validation.

Conclusion:

In the light of available information and the usefulness of the placental extract, it is necessary that the formulations of various desirable properties may be developed to meet the clinical requirements in several treatment paradigms. The potential effects of placental extract-based therapy are an interesting topic for investigation.
Analysis of post-stroke anxiety (PSA) factors during the COVID-19 pandemic in Indonesia
Authors: Mufidah Nisfil , Suhron M. , Wahyudi Rahmad
Published: December 2021

This study aims to determine the incidence of PSA and the factors that influence it. The study was conducted on 78 patients with neurologic stroke at ANNA Medika Madura Hospital from May to July 2021 and aged over 40 years using simple random sampling. Measuring tools using Hamilton Anxiety Rating Scale, vascular disorders, stroke disorders, and Neurophysiological disorders. Analysis using the Structural Equation Modeling with the software Partial Least Square. Based on the results of statistical tests, it was found that demographic factors (T-statistics 1.756), vascular disorders factor (T-statistics 2.873), stroke disturbance factor (T-statistics 2.164), and neurophysiological disorders factor (T-statistic 3.070). The factor that had the greatest influence on PSA was the neurophysiological factor, with the most influencing subfactor being the cognitive function of stroke patients indicated with MMSE results. Stroke patients with decreased cognitive function will affect the effectiveness of the rehabilitation program. This will lead to an increase in their anxiety with the subsequent effect being a decrease in the quality of life in stroke patients. So rated important for the power of Health assess cognitive function is to reduce PSA.
Indexs in About The Authors Adi Susanto ORCID iD	Universitas Gadjah Mada Indonesia Nico Chandra Aditya Fakultas Biologi, Universitas Gadjah Mada Indonesia Sari'ah Cintami Damayanti Fakultas Biologi, Universitas Gadjah Mada Indonesia Hendry Saragih Fakultas Biologi, Universitas Gadjah Mada User You are logged in as... widi_1 My Profile Log Out Notifications View (59 new) Manage Journal Content Search Search Scope Browse By Issue By Author By Title Information For Readers For Authors For Librarians Keywords CMT IL-2 JSS babi classical swine fever conjunctivitis coryza demografi peternakan diazinon extract of dragon fruit peel fascioliasis liver liver histopathology malondialdehyde (MDA) mastitis subklinis mononuclear inflammatory cells open wound papua prevalensi sapi perah vaksinasi Pengaruh Pemberian Infused Water Buah Naga Merah (Hylocereus polyrhizus (F.A.C. Weber) Britton & Rose) Terhadap Performa Pertumbuhan Broiler
Authors: Susanto Adi , Aditya Nico Chandra , Damayanti Sari'ah Cintami , Saragih Hendry
Published: December 2021

Penggunaan Antibiotics Growth Promotors (AGP) sintetis dalam pemeliharaan ayam broiler menyebabkan efek negatif jangka panjang. Penggunaan infused water buah naga merah (IWBNM) sebagai suplemen alami sangat diperlukan. Penelitian dilakukan guna mengetahui pengaruh IWBNM terhadap pertumbuhan ayam broiler. Rancangan acak lengkap menggunakan 5 kelompok dengan tiga ulangan adalah desain penelitian yang digunakan. Setiap ulangan berjumlah 20 ekor DOC. IWBNM diberikan melalui air minum. Perlakuan dilakukan hingga umur 21 hari. Perlakuan terdiri atas P0 (Kontrol) air biasa : P (Perlakuan) konsentrasi buah naga. Kelompok perlakuan yaitu 1 = konsentrasi 0,25% ; 2 = konsentrasi 0,5% ; 3 = konsentrasi 1% ; 4 = konsentrasi 2%. Data penelitian diuji dengan One Way ANOVA, dengan uji Least Significant Difference (LSD) dan Duncan sebagai uji lanjutan. Hasil pengujian, 1 ml IWBNM mengandung total flavonoid sebesar 676,19 µg. Pemberian IWBNM selama 21 hari secara umum dapat meningkatkan performa pertumbuhan ayam broiler. Pengukuran morfometri dan berat badan pada hari ke-21 merupakan indikator peningkatan performa pertumbuhan ayam broiler dengan rata-rata performa paling tinggi terdapat dalam kelompok P4 dibandingkan dengan P1, P2, P3, dan P0. Sedangkan untuk rasio organ visceral terhadap berat badan, IWBNM tidak berpengaruh signifikan baik pada organ jantung atau hepar
Problems of European civil proceedings
Authors:   O. A. Derbisheva Donetsk Academy of Internal Affairs of the Ministry of Internal Affairs of the DPR, Derbisheva O. A.
Published: December 2021

. The topic of this article is devoted to the analysis of the problems of European civil proceedings. The author of this article has studied the theoretical foundations and regulatory framework related to this issue. The purpose of this work is to study the theoretical and practical aspects of European civil proceedings, identify existing problems and search for possible solutions. Methodological basis: The article discusses the main directions and branches of the branch of the European civil procedure. During the research, methods of observation, generalization, comparison, analysis were used. Results: In the course of the work, the system of European court proceedings in civil cases was studied. The conducted research has revealed the problems existing in the system of the European civil procedure. Research implications: The study of the directions and branches of the branch of the European civil procedure and the practice of its application can serve as a tool for improving the current domestic legislation, and identifying problems existing in foreign countries will help prevent the adoption of irrational and unnecessary legal acts.
Responsibility of the employer for non-compliance with the terms of the employment contract
Authors:   Z. A. Alieva Dagestan State University, Alieva Z. A.
Published: December 2021

The article is devoted to the issues of the employer's liability for non-compliance with the terms of the employment contract. The aim of the study is to examine the types of liability of employers for violation of the terms of the employment contract. It says that employers guilty of non-compliance with the terms of the employment contract are subject to material, disciplinary, civil, administrative and criminal liability. The problematic issues of compensation for damage to an employee caused by violation of labor legislation are considered. Revealed and substantiated the need for timely payment of wages to employees. Analyzed materials of judicial practice concerning the illegal dismissal of an employee, as well as non-payment of wages to the employee. It is concluded that employers who are guilty of non-compliance with the terms of the employment contract are liable in the cases and in the manner established by the Labor Code of the Russian Federation and other federal laws
Problems of appointment and execution of a criminal punishment in the form of a penal
Authors:   A. А. Akaeva Dagestan State University, Akaeva A. А.
Published: December 2021

The article analyses problematic issues in the enforcement of a criminal penalty in the form of a fine, and examines the actual situation of a fine in the system of criminal penalties Despite the efforts of the legislature to make fines the most common form of criminal punishment, recent statistics show the contrary. The low level of enforcement of the penalty of a fine is indicative of the existence of problems in the legal regulation, especially with regard to the enforcement of the penalty of a fine imposed as an additional penalty. On the basis of the results of the study, some proposals have been made to remedy the problems
The right of Police officers and the Criminal-executive system to use firearms: some issues of theory and practice
Authors:   A. А. Alimov Professional Training Center of the Main Directorate of the Ministry of Internal Affairs of Russia for the Chelyabinsk Region, Alimov A.  А. , Yunusov S. A. ,   S. A. Yunusov Research Institute of the Federal Penitentiary Service of Russia
Published: December 2021

The article is devoted to the analysis of the Federal Law «On the Police» and the law of the Russian Federation «On Institutions and Bodies Executing Criminal Sentences in the Form of Imprisonment», which empowers the police and the penal system with the right to use firearms. Possible problems of the implementation of the provisions of the legislation are identified, specific measures are proposed to improve the efficiency of legal regulation of the use of firearms by police officers and the penal system
To the question of the need to maintain accounts in social networks by the Federal Penitentiary Service of the Russian Federation
Authors:   A. О. Kashtanova Research Institute of the Federal Penitentiary Service of Russia, Kashtanova A. О.
Published: December 2021

Social networks are online platforms that allow you to create social relationships between people based on their interests. The article lists the most popular social networks in Russia, identifies electronic resources in which the Federal Penitentiary Service of Russia actively brings information about the professional activities of the department. The purpose of this article is to determine the need to maintain accounts in social networks of the Federal Penitentiary Service of Russia, as well as the format of the information presented to attract public interest in the activities of the department. When writing the work, we used the statistical method (when studying and analyzing statistical data from a population survey, automatic measurement of Internet use), the method of comparative analysis (when studying data from a population survey of different age categories), the formal logical method (when formulating research conclusions), and other general scientific and private scientific methods of cognition (deduction, induction, etc.). In the course of the study, conclusions were formulated regarding the need for the use of social networks by the founder, as well as the centralization of the list of accounts in social networks on the official website of the department.
On some problems of legal regulation of the use of personal data during the election campaign
Authors:   V. L. Rasskazov Kuban State Agrarian University named after I.T. Trubilin, Rasskazov V. L. , Pastukhov M. M. ,   M. M. Pastukhov Kuban State Agrarian University named after I.T. Trubilin
Published: December 2021

This article is devoted to the analysis of some problems of legal regulation of the use of personal data during election campaigning. The authors carried out a study of the risks of using personal data, including those obtained by owners and operators of social networks and communication platforms on the Internet, for the purpose of political campaigning during the election campaign. The paper develops and justifies a system of proposals to resolve these problems, including: to counteract illegal actions related to the processing, transfer or use of personal data for political agitation; to supplement the current legislation with a number of terms, for example, "targeted advertising".
On the question of agrarian, administrative and judicial reform in the Kurin Khanate in the XIX century
Authors:   R. A. Bogdanov Dagestan State University, Bogdanov R. A.
Published: December 2021

The article is devoted to information on the history of the Kurin Khanate and Dagestan, especially in the XIX century, about the orders that reigned in the khanates, about the mountain rulers and their power. Along with administrative reforms, tsarism also implemented judicial reform in the North Caucasus, which was completely subordinated to the interests of Russia and its policies in the region. This reform was carried out, gradually replacing the centuries-old judicial system in Cure, based on customary law. The reform of the rural government occupies a prominent place in the administrative reform of the Dagestan region. The need for its implementation stemmed from the need to create a unified system of rural administration: rural (aul) public administration was the lowest step of the administrative ladder. The main issues of the social life of rural society were solved by the village (aul) assembly. Administrative-territorial transformations of the 60-70s of the XIX century were practically aimed at strengthening control over the local population.
State council in the light of the 2020 constitutional reforms
Authors:   P. R. Magomedova Dagestan State University, Magomedova P. R.
Published: December 2021

The article analyzes the prerequisites for changing the legal status of the State Council of the Russian Federation, analyzes the Federal Law "On the State Council of the Russian Federation" dated December 8, 2020 No. 394-FZ and studies the changes that came into force in the light of the constitutional reforms of 2020. According to this Law, the State Council of the Russian Federation should become a real mechanism of public power in Russia, while remaining an advisory body and a platform for coordinating the interests of the regions and the center. The author conducted a comparative analysis of the State Council, which acted in accordance with the Presidential Decree of 2000, and the law adopted in 2020. Based on the conducted research, the author concludes that the amendments to the Constitution of the Russian Federation adopted in 2020 are timely and necessary in order to restore the existing government.
Editorial Comment on the Article by Mushkin M.A. et al. “Effect of Prehospital Pause on the Outcomes of Emergency Decompression and Stabilization Procedures in Patients with Tumor and Infectious Spine Diseases”
Authors: Ptashnikov Dmitry A.
Published: December 2021

The editorial comment evaluates the current state of issue of medical care at urgent states caused by pathological vertebral fractures and spinal cord compression in patients with spine destructive diseases. The rare occurrence of pathology and the deficiency of objective data determine the lack of consensus on the medical care for this category of patients. The article by M.A. Mushkin et al helps to understand how the prehospital pause affects the outcomes of emergency decompression and stabilization procedures in patients with tumor and infectious diseases of the spine, as well as to determine how much time the surgeon has at his disposal. The author of the comment believes that close cooperation of orthopedic surgeons, neurosurgeons, oncologists is necessary to solve this problem. Even despite the absence of oncologists in the staff of emergency hospitals, telemedicine allows to receive methodological support in a timely manner for making a correct decision for each patient. Interaction between clinicians, radiologists and pathologists is equally important. An important aspect is continuity in patient care. An urgently performed spinal cord decompression is only a stage of the complex treatment. Such patients should be provided with accurate routing depending on the diagnosis and the treatment early outcome.