bluuebunny/crossref_metadata_2025 huggingface dataset:
Epidemiology of Yam Viruses in Guadeloupe: Role of Cropping Practices and Seed-Tuber Supply
Authors: Diouf Mame Boucar , Guyader Sébastien , Gaspard Olyvia , Francius Eric , Teycheney Pierre-Yves , Umber Marie
Published: October 2022

The epidemiology of yam viruses remains largely unexplored. We present a large-scale epidemiological study of yam viruses in Guadeloupe based on the analysis of 1124 leaf samples collected from yams and weeds. We addressed the prevalence of cucumber mosaic virus (CMV), Cordyline virus 1 (CoV1), Dioscorea mosaic associated virus (DMaV), yam asymptomatic virus 1 (YaV1), yam mosaic virus (YMV), yam mild mosaic virus (YMMV), badnaviruses, macluraviruses and potexviruses, and the key epidemiological drivers of these viruses. We provide evidence that several weeds are reservoirs of YMMV and that YMMV isolates infecting weeds cluster together with those infecting yams, pointing to the role of weeds in the epidemiology of YMMV. We report the occurrence of yam chlorotic necrosis virus (YCNV) in Guadeloupe, the introduction of YMMV isolates through the importation of yam tubers, and the absence of vertical transmission of YaV1. We identified specific effects on some cropping practices, such as weed management and the use of chemical pesticides, on the occurrence of a few viruses, but no crop-related factor had a strong or general effect on the overall epidemiology of the targeted viruses. Overall, our work provides insights into the epidemiology of yam viruses that will help design more efficient control strategies.
Kiwira Virus, a Newfound Hantavirus Discovered in Free-tailed Bats (Molossidae) in East and Central Africa
Authors: Weiss Sabrina , Sudi Lwitiho E. , Düx Ariane , Mangu Chacha D. , Ntinginya Nyanda Elias , Shirima Gabriel M. , Köndgen Sophie , Schubert Grit , Witkowski Peter T. , Muyembe Jean-Jacques , Ahuka Steve , Klempa Boris , Leendertz Fabian H. , Krüger Detlev H.
Published: October 2022

A novel hantavirus, named Kiwira virus, was molecularly detected in six Angolan free-tailed bats (Mops condylurus, family Molossidae) captured in Tanzania and in one free-tailed bat in the Democratic Republic of Congo. Hantavirus RNA was found in different organs, with the highest loads in the spleen. Nucleotide sequences of large parts of the genomic S and L segments were determined by in-solution hybridisation capture and high throughput sequencing. Phylogenetic analyses placed Kiwira virus into the genus Mobatvirus of the family Hantaviridae, with the bat-infecting Quezon virus and Robina virus as closest relatives. The detection of several infected individuals in two African countries, including animals with systemic hantavirus infection, provides evidence of active replication and a stable circulation of Kiwira virus in M. condylurus bats and points to this species as a natural host. Since the M. condylurus home range covers large regions of Sub-Saharan Africa and the species is known to roost inside and around human dwellings, a potential spillover of the Kiwira virus to humans must be considered.
Structural Insights into Common and Host-Specific Receptor-Binding Mechanisms in Algal Picorna-like Viruses
Authors: Wang Han , Munke Anna , Li Siqi , Tomaru Yuji , Okamoto Kenta
Published: October 2022

Marnaviridae viruses are abundant algal viruses that regulate the dynamics of algal blooms in aquatic environments. They employ a narrow host range because they merely lyse their algal host species. This host-specific lysis is thought to correspond to the unique receptor-binding mechanism of the Marnaviridae viruses. Here, we present the atomic structures of the full and empty capsids of Chaetoceros socialis forma radians RNA virus 1 built-in 3.0 Å and 3.1 Å cryo-electron microscopy maps. The empty capsid structure and the structural variability provide insights into its assembly and uncoating intermediates. In conjunction with the previously reported atomic model of the Chaetoceros tenuissimus RNA virus type II capsid, we have identified the common and diverse structural features of the VP1 surface between the Marnaviridae viruses. We have also tested the potential usage of AlphaFold2 for structural prediction of the VP1s and a subsequent structural phylogeny for classifying Marnaviridae viruses by their hosts. These findings will be crucial for inferring the host-specific receptor-binding mechanism in Marnaviridae viruses.
Combined Effects of Polystyrene Nanoplastics and Enrofloxacin on the Life Histories and Gut Microbiota of Daphnia magna
Authors: Maszczyk Piotr , Kiersztyn Bartosz , Gozzo Sebastiano , Kowalczyk Grzegorz , Jimenez-Lamana Javier , Szpunar Joanna , Pijanowska Joanna , Jines-Muñoz Cristina , Zebrowski Marcin Lukasz , Babkiewicz Ewa
Published: October 2022

The effect of nanoplastics (NPs) has been shown to interact with the effect of pollutants, including antibiotics. However, little is known about studies performed on freshwater organisms. In this study, we aimed to test the hypothesis that both NPs and antibiotics affect the life history traits of freshwater planktonic Daphnia magna, a model organism in ecotoxicological research, as well as the metabolic and taxonomic fingerprint of their gut microbiota, and whether there is an interaction in the effect of both stressors. To assess this, we experimented with the effect of different spherical polystyrene nanoplastic concentrations and antibiotic enrofloxacin measured through (i) the Daphnia body size and their selected reproductive parameters (the clutch size, egg volume, and total reproductive investment), (ii) the metabolomic diversity of gut microbiota (the respiration rate and the relative use of different carbon sources), and (iii) the microbial taxonomic diversity in the Daphnia intestine. Our results supported the hypothesis as each of the stressors on its own significantly influenced most of the measured parameters, and because there was a significant interaction in the effect of both stressors on all of the measured parameters. Therefore, the results suggest an interactive negative effect of the stressors and a possible link between the observed effects at the different levels of a biological organisation.
Using IT to assess the functional efficacy of food products
Authors:   Department of Commodity Science and Commodity Expert Examination, Plekhanov Russian University of Economics, Ezhova M.V. , Eliseeva L.G. ,   Department of Commodity Science and Commodity Expert Examination, Plekhanov Russian University of Economics, Molodkina P.G. ,   Department of Commodity Science and Commodity Expert Examination, Plekhanov Russian University of Economics, Santuryan T.A. ,   Department of Commodity Science and Commodity Expert Examination, Plekhanov Russian University of Economics
Published: October 2022

The physiological role of vitamin D and its importance in the diet for the formation of adaptive immunity to infectious alimentary diseases are substantiated; the consequences and causes of its deficiency are described. The effectiveness of using IT for assessing the functional efficacy of students' diets and the formation of a balanced diet to provide nutritional support for the body is shown
Revelando a simetria de gauge do Modelo CFJ massivo através do formalismo Gauge Unfixing aprimorado
Authors:   , Alves Paulo Roberto Fernandes
Published: October 2022

No presente trabalho de dissertação de mestrado, analisamos uma versão aprimorada do formalismo de Gauge Ufixing (GU) no modelo de Carroll-Field-Jackiw massivo, modelo esse que viola as invariâncias de Lorentz e de gauge, com o objetivo de revelar simetrias ocultas, e recuperar a invariância de gauge, que é um principio fundamental do modelo padrão da física de partículas. Nesse processo, como é de costume, convertemos esse sistema com vínculos de segunda classe em um com vínculos de primeira classe, obtendo dois modelos invariantes de gauge. Verificamos que os parêntesis de Poisson das variáveis invariantes de gauge, obtidas por meio do formalismo GU, coincidem com os parêntesis de Dirac entre as variáveis originais de segunda classe do espaço de fase. Finalmente obtemos duas lagrangianas invariantes de gauge onde uma delas representa a forma de Stueckelberg. Também analisamos os aspectos gerais do modelo de Maxwell-Carroll-FieldJackiw masssivo, como as equações de movimento, as ondas eletromagnéticas, modificadas pela presença do termo campo de fundo e o termo de Proca.
Direitos fundamentais na jurisprudência constitucional brasileira: uma análise da aplicação da máxima da proporcionalidade e da fórmula do peso aos julgados do STF sobre o princípio da liberdade de expressão
Authors:   , Baeta Camila Silva
Published: October 2022

O objeto de estudo deste projeto relaciona-se ao exame crítico da aplicação da máxima da proporcionalidade e da fórmula do peso – teorias desenvolvidas por Robert Alexy – na jurisprudência constitucional brasileira. Para solucionar conflitos de interesses originados na colisão entre dois ou mais princípios de direitos fundamentais, a máxima em questão deve ser aplicada de forma procedimentalmente correta a fim de trazer racionalidade à decisão judicial. Portanto, especificamente para este trabalho, pretende-se analisar processos em que se verifique a colisão entre o princípio da liberdade de expressão e outro princípio de direito fundamental, com base constitucional. Nesse contexto, o estudo se divide em duas partes. A primeira, uma pesquisa teórica, mediante revisão bibliográfica, identificando-se os elementos do pensamento de Robert Alexy que são essenciais à investigação desenvolvida, porquanto seja o marco teórico utilizado. A segunda, uma pesquisa empírica, com o levantamento da jurisprudência do Supremo Tribunal Federal no tratamento do princípio da liberdade de expressão. Ao final, conclui-se que os ministros do STF se referem à máxima da proporcionalidade com uma frequência bem maior do que aos critérios determinantes para o preenchimento das variáveis da fórmula do peso, mesmo que os percentuais de não utilização de ambas as construções teóricas – máxima da proporcionalidade e fórmula do peso – sejam bastante expressivos.
Virtual Staining of Defocused Autofluorescence Images of Unlabeled Tissue Using Deep Neural Networks
Authors: Zhang Yijie , Huang Luzhe , Liu Tairan , Cheng Keyi , de Haan Kevin , Li Yuzhu , Bai Bijie , Ozcan Aydogan
Published: October 2022

Deep learning-based virtual staining was developed to introduce image contrast to label-free tissue sections, digitally matching the histological staining, which is time-consuming, labor-intensive, and destructive to tissue. Standard virtual staining requires high autofocusing precision during the whole slide imaging of label-free tissue, which consumes a significant portion of the total imaging time and can lead to tissue photodamage. Here, we introduce a fast virtual staining framework that can stain defocused autofluorescence images of unlabeled tissue, achieving equivalent performance to virtual staining of in-focus label-free images, also saving significant imaging time by lowering the microscope’s autofocusing precision. This framework incorporates a virtual autofocusing neural network to digitally refocus the defocused images and then transforms the refocused images into virtually stained images using a successive network. These cascaded networks form a collaborative inference scheme: the virtual staining model regularizes the virtual autofocusing network through a style loss during the training. To demonstrate the efficacy of this framework, we trained and blindly tested these networks using human lung tissue. Using 4× fewer focus points with 2× lower focusing precision, we successfully transformed the coarsely-focused autofluorescence images into high-quality virtually stained H&E images, matching the standard virtual staining framework that used finely-focused autofluorescence input images. Without sacrificing the staining quality, this framework decreases the total image acquisition time needed for virtual staining of a label-free whole-slide image (WSI) by ~32%, together with a ~89% decrease in the autofocusing time, and has the potential to eliminate the laborious and costly histochemical staining process in pathology.
Improving Insurance Protection for Rare Diseases: Economic Burden and Policy Effects — Simulation of People With Pompe Disease in China
Authors: Chen Shanquan , Dong Dong
Published: October 2022

Background: The economic burden of Pompe disease (PD) is under-researched. This study aimed to fill this gap and provide evidence-based suggestions for policy improvement based on policy simulation. Methods: Data were derived from a nationally based cross-sectional survey on rare diseases in early 2018. Answers from 92 PD patients were used for data analysis and simulation. Catastrophic health expenditure (CHE) and impoverishment due to illness (IDI) were adopted to measure PD patients’ economic burden. Two typical reimbursement patterns, a dosage-based model and a cost-based model, in China were simulated. Results: Twenty-four pediatric and 68 adult PD patients were investigated. Families with pediatric PD patients on average had lower annual household incomes than families with adult PD patients (RMB 37 890 vs. RMB 66 120). The direct medical expense and out-of-pocket expenses were almost double for pediatric patients compared with adult patients (RMB 120 050 vs. RMB 66 350; RMB 112 710 vs. RMB 57 940, respectively). The direct non-medical expense for patients was almost six times the expense of adult patients (RMB 73 790 vs. RMB 13 080, respectively). About 88.24% of families with pediatric PD patients and 67.21% of families with adult PD patients suffered from CHE. Around 84.21% of families with pediatric PD patients and 45.90% of families with adult PD patients were forced to live in poverty due to illness. The simulation indicated that, although the two current reimbursement schemes helped reduce CHE, they almost had no effect on reducing IDI; the dosage-based model was more sensitive to changes in policy parameters. Conclusion: Our study highlighted the alarmingly high disease burden faced by PD patients with first-hand patient-reported evidence. Our series of simulations could be a good reference for China and other countries to improve their reimbursement policy regarding PD.
Is the Blue Economy possible in Poland?
Authors: Szyja Paulina , Michalak Dorota
Published: October 2022

Although the concept of the blue economy is relatively new, the European Union is already taking steps to make it a reality. Therefore, it is necessary to determine the scope of activities that should be carried out for the sustainable development of the blue economy in Poland. It was decided to analyze basic data and indicators to verify whether the Polish maritime and coastal economy meets the goals of the blue economy. During the research, it became apparent that inaccuracies in terminology affect the selection of indicators. Therefore, the definitions and classification of sectors related to the blue economy were verified. Based on the literature review and the available data, the Polish maritime and coastal economy has considerable potential to be transformed into a blue economy. However, major barriers have also been identified, the removal of which requires a systematic approach. Furthermore, the benefits and costs associated with the transformation are highlighted.
Determinants and effects of Poland’s road accidents in the context of the 2030 agenda for sustainable development – poviat level analysis for the years 2010-2019
Authors: Romanowska Aleksandra , Pangsy-Kania Sylwia , Budzyński Marcin , Wierzbicka Katarzyna , Prystrom Joanna
Published: October 2022

The objective of the research was to assess how selected factors influence road safety in Poland’s poviats. To that end, an analysis was conducted of road accident determinants and effects in the poviats in the years 2010-2019. The time horizon fits in with Goal 3.6. of Agenda 2030 which is to halve the number of global deaths and injuries from road traffic accidents by 2020. The article presents the results of the analysis for the following determinants: the rate of car ownership by poviat, poviat spending on transport and length of road network, and quality of road infrastructure. The research problem was to establish which of the poviats are closest to achieving Goal 3.6. of  Agenda 2030 and how likely it is, and, as a consequence, which of the poviats should step up their road safety policies to align them to the targets set out in the Agenda. To identify groups of poviats sharing similar characteristics, they were grouped using the k-means method. Five groups of poviats were identified and analysed for how their road safety indicators changed between 2010 and 2019. The results of the analysis show that the highest fatality reduction (-40%) was achieved by urban poviats with the highest per capita spending on transport. The same poviats, however, have the highest increases in serious injuries (+30%). The analyses show that Polish poviats are still far from achieving Goal 3.6 of Agenda 2030. The research results presented in the article are original for the poviat level.
Value of recreation utility of the Polish Baltic coast – willingness to pay or willingness to declare?
Authors: Berbeka Krzysztof , Misiak Tomasz
Published: October 2022

The idea of improving the quality of the Baltic Sea enjoys common understanding and acceptance. An implementation of this idea requires a cost benefit analysis in order to define the correct scope of intervention. Monetary valuation of the benefits arising from the quality improvement was conducted for the Baltic Sea with the use of contingent valuation method, choice experiments, and travel cost method. Crucial sources for such valuation were the stated preferences of the respondents. Availability of ex-post data describing the occupancy rate of the swimming sites on the Polish stretch of the Baltic coast, collected for four consecutive years, makes it possible to compare two concepts i.e. the ex-ante declarations concerning willingness to use high quality environment and the actual consumers’ choices. The results reveal serious discrepancies between the ex-ante and ex-post methods.
Meningococcal Infection in the Republic of Belarus: from "Harmless" Carrier to Sepsis
Authors: Федорова И.В. , Сергиенко Е.Н. , Романова О.Н. , Высоцкая В.С. , Запольская В.В.
Published: October 2022

Менингококковая инфекция на сегодняшний день не утратила своей актуальности, несмотря на достижения современной медицины, в том числе в вопросах развития вакцинопрофилактики. С клинических позиций актуальность МИ определяется риском возникновения генерализованных форм с развитием осложнений, ведущих к долговременным последствиям, и высокими показателями летальности.Цель исследования. Изучение эпидемиологических особенностей менингококковой инфекции в Республике Беларусь за период с 1998 г. по 2020 г.Материалы и методы. Материалом для изучения механизма развития и проявлений эпидемического МИ явились данные о случаях заболевания этой инфекцией, зарегистрированных на территории Республики Беларусь за период с 1998 по 2020 г. Результаты. В статье представлены эпидемиологические особенности менингококковой инфекции и возможности специфической профилактики, описаны клинические случаи генерализованных форм.Заключение. На фоне выраженного тренда к снижению показателей заболеваемости установлен неснижаемый уровень популяционной летальности, который находился в пределах от 3,8% в 2008 г. до 15,7% в 2020 г. За последние 10 лет наблюдения в структуре заболевших МИ доля детского населения составляет 78,3% с максимальным удельным весом в группе детей 0–2 лет (56,5%).

Meningococcal infection has not lost its relevance today, despite the achievements of modern medicine, including in the development of vaccination. From a clinical standpoint, the relevance of MI is determined by the risk of generalized forms with the development of complications leading to long-term consequences and high mortality rates.The purpose of work. To study the epidemiological features of meningococcal infection in the Republic of Belarus for the period from 1998 to 2020.Materials and methods. Data on cases of this infection registered on the territory of the Republic of Belarus for the period from 1998 to 2020 were the material for studying the mechanism of development and manifestations of epidemic MI.Results. The article presents the epidemiological features of meningococcal infection and the possibilities of specific prevention; clinical cases of generalized forms are described. Conclusion. Against the background of a pronounced trend towards a decrease in morbidity rates, an irreducible level of population mortality was established, which ranged from 3.8% in 2008 to 15.7% in 2020. Over the past 10 years of observation, the proportion of children in the structure of cases of MI is 78.3%, with the maximum proportion in the group of children 0–2 years old (56.5%).
Efisiensi Model Mesh Kasus Deteksi Simulasi Korosi Beton Bertulang Menggunakan Metode Axisymmetric Mesh Problem
Authors: Ihsan Muhammad , Susanto Herdi
Published: October 2022

In this study, a computational numerical modelling for corrosion simulation in reinforcing steel is developed. The corrosion simulation using Boundary element Method (BEM) and focusing for cylindrical reinforced concrete (RC). The main problem is high performance computer was required for the reinforced concrete corrosion simulation. Therefore, main purpose of this study is to reduce the needs of high-performance computer during the corrosion simulation. For the purpose, axisymmetric computational problem was integrated to the numerical BEM that considered able to reduce the computational effort. On the analysis process, the whole axial RC structures column was modeled by Laplace equation. The boundary condition for the corroded and non-corroded areas on the reinforcing steel (rebar) were represented by their established polarization curve. The Laplace equation was solved by BEM, thereby the potential on the structure can be analyzed. The simulation results show the similar potential distribution between BEM computational modelling by triangle element mesh and improvement BEM using axisymmetric element mesh problem. The simulation shows a significant differences, thereby the corrosion simulation using axisymmetric element mesh problem significantly reduces the computer effort in term of time-consuming and computer effort for the simulation. Thus, the improvement of the axisymmetric modelling for BEM becomes a powerful method for reducing the computational effort in term of cylindrical reinforcing steel corrosion simulation. Keywords— corrosion modelling, axisymmetric, BEM, cylindrical column, reinforced concrete
KUR KORUMALI MEVDUAT HESABINA TANINAN VERGİ AYRICALIKLARININ BÜTÇEYE ETKİLERİ
Authors: YAYMAN Derya
Published: October 2022

Türk Lirasının Amerikan Doları karşısındaki değer kaybını önlemek için getirilen kur korumalı mevduat hesabı üç ayı geride bırakmıştır. Kur korumalı mevduat hesabı önce gerçek kişilerin belli döviz cinsinden hesaplarına yönelik getirilmiş, sonra kapsama altın hesapları alınmış, en sonunda ise tüzel kişiler sisteme dahil edilmiş ve bu hesaplara dönüşüm halinde kurumlar ve gelir vergisi avantajları getirilmiştir. Kur korumalı mevduat hesabının başlangıçta bütçeye yük olmayacağı, çünkü Merkez Bankasından karşılanacağı belirtilmiştir. Ancak her vergisel ayrıcalık vergi harcaması niteliğinde olduğundan, devlet bütçesi için bir giderdir. Araştırmanın amacı, kur korumalı mevduat sistemine tanınan vergi ayrıcalıklarının devlet bütçesine maliyeti olup-olmadığını tartışmaktır. Literatür taraması yapılmış ve konu ile ilgili çalışmalar incelenmiştir. Araştırma metodolojisi nitel içerik analizidir. Veri kaynakları; konu ile ilgili çıkarılan kanunlar, tebliğler, sirkülerler, açıklamalar, Hazine ve Maliye Bakanlığının bütçe istatistikleri ve TCMB’ nın para ve banka istatistikleridir. Çalışmanın bulguları; kamunun üstlendiği şartlı yükümlülüğün yurt içi yerleşiklere, TL’nin mali değerini koruma konusunda güven vermesi, yurt dışında yaşayan Türklere tanınan net getiri garantisini belirlemenin henüz mümkün olmadığı, bütçe giderlerinin incelenen dönem itibariyle arttığı, ancak bütçe gelirlerinin de neredeyse bu artış düzeyinde arttığı, faiz dışı fazlanın arttığı, dolayısıyla henüz bütçeye etkisinin düşük kaldığı, kur korumalı mevduat hesaplarındaki artışın maliyetinin giderek arttığı ve esas riskin kurda öngörülmeyen sıçramalar olduğudur
ENGELLİ HAKLARI HAREKETİ: BİR AKTİVİST HAREKET OLARAK GELİŞİMİ, TALEPLERİ VE TOPLUMSAL BAĞLAMI
Authors: KALDIK Behçet
Published: October 2022

Engelli hakları hareketi, engellilerin yüzyıllarca yaşadıkları sorun ve engellere yönelik bir itiraz olarak ancak 1960’lı yıllarda ortaya çıkmaya başlamıştır. Engellilik, ilk dönemlerde daha çok ahlaki bir çöküntünün cezası biçiminde değerlendirilirken, bilimin gelişmesi ve rasyonel düşüncenin öne çıkmasıyla patoloji ve anomali olarak görülmüş; bireyler, tıp ve rehabilitasyon gibi uygulamalı disiplinlerle tedavi edilmeye çalışılmıştır. Bu anlayış ekseninde engelli bireyler, çeşitli kurumlara kapatılmış ve toplumsal bağlamdaki ayrımcılıklar, engeller ve ön yargılar sorunun bir parçası olarak görülmemiştir. Engelli hakları hareketi ise bu tıbbi indirgemeci anlayışın ayrımcı, damgalayıcı ve dışlayıcı uygulamalarına karşı çıkarak, yaşanan sorunların kaynağının aktörlerin bedeninde değil, toplumsal ve kültürel yapıda aranması gerektiğini savunmuştur. Böylece engelli hakları hareketi, engellilerin eşit vatandaşlık haklarına sahip olmasını, bağımsız yaşamasını ve kendileriyle ilgili düzenlemelerde görüş ve düşüncelerinin dikkate alınmasını talep etmiştir. Ayrıca engellilerin önündeki toplumsal bariyerlerin kaldırılarak yeni bir engellilik kültürünün ve kimliğinin inşa edilmesi için mücadele etmiştir. Dolayısıyla bu çalışmada, engelli hakları hareketinin gelişimi, mücadele alanları ve talepleri üzerinde durulmuştur.
Valoración económica de los servicios ambientales de la cuenca del río Coata, Puno-Perú
Authors: Quispe-Mamani Julio , Quispe-Mamani Felix , Roque-Guizada Cesar , Yapuchura-Saico Cristobal , Catachura-Vilca Alberto
Published: October 2022

El objetivo fue de valorar económicamente los servicios ambientales de la cuenca del río Coata; así mismo, determinar la disponibilidad a pagar por la mejora de los servicios ambientales e identificar las variables socio-económicas que determinan la disposición a pagar. Se aplicó el método de valoración contingente y modelo econométrico logit binomial, con una muestra de 369 hogares que viven alrededor de la cuenca, para esto se utilizó la técnica de recolección de datos de fuente primaria y como instrumento se utilizó la encuesta, sobre la población que radica en la cuenca, utilizando los paquetes estadísticos SPSS 25.0 y Stata 16.0 para la estimación y contraste de hipótesis. Se determinó que el valor económico de la DAP asciende a 4.88 soles mensuales, por lo que evidencia la existencia de una plena disponibilidad a pagar por parte de las familias que habitan en las cercanías de la cuenca del río. Finalmente, la DAP es explicado por la edad en 2.77%, la educación en 3.1%, la frecuencia de uso del servicio ambiental en 2.3% y distancia al río en 2.3%.
SNEDDS Formulation of Black Cumin Seed Oil using Tween 80 and Sorbitol as a Surfactant and Cosurfactant
Authors: Wahyuningsih Iis , Latief Yenni
Published: October 2022

Black cumin seed oil has many benefits. One of which is as an anticancer, it can be used as an opportunity to develop drugs that utilizes the black cumin seed oil. A method to improve the stability and absorption of the drug in the body is within the formulation of Self Nano Emulsifying Drug Delivery System (SNEDDS). This study aims to determine whether the black cumin seed oil can be made into SNEDDS formula with tween 80 and sorbitol as a surfactant and cosurfactant along with the establishment for the optimal formula. SNEDDS formula of black cumin seed oil was optimized using SLD method by DX.10 software. SNEDDS formula was made using tween 80 as surfactant and sorbitol as cosurfactant. Previously carried out with the manufacturing of a trial formula to determine the lower and upper value of each component, then 14 formulas were made based on DX.10. The formula were evaluated for transmittance percentage in 650 nm wavelength and emulsification time of 37oC. Results of the tests included in DX10 is to obtain the optimal formula. The optimal formula was validated by t-test and evaluated for droplet size, zeta potential, and stability test of nanoemulsion in artificial gastric fluid (AGF) and artificial intestinal fluid (AIF) for 4 hours. The results showed that the proportion of 13% black cumin seed oil, 60% tween 80 and 27% sorbitol is able to establish the optimal SNEDDS formula of black cumin seed oil. Transmittan value of the optimal formula was 92% with the emulsification time of 56 seconds, SNEDDS black cumin seed oil droplet size of 21.5 nm, zeta potential value -31.5 mV and nanoemulsion stable in the AIF and AGF.
Formulation of Moringa oleifera Leaf Cereal Granules with Variation Types of Binder and Xanthan Gum Concentration
Authors: Rani Karina Citra , Parfati Nani , Fitriani Endang Wahyu , Sari Dina Novita , Islamia Hilmiyatul , Wulansari Tiara Yuni
Published: October 2022

Moringa leaves contain macronutrients and micronutrients, potential to be developed into cereal products in the form of granules using the wet granulation method. The type of binder and the concentration of the suspending agent are the main factors that affect the physical characteristics and proximate content of cereals. In this research, 6 formulas of cereal granules were optimized with various types of binders (arrowroot flour, sorghum flour, cornstarch) and variations in the concentration of xanthan gum (0.5% and 1.0%). This study aims to obtain a granule formula of Moringa leaf cereal that meets the requirements of physical, chemical, proximate, and heavy metal characteristics. The results of the evaluation of the granule characteristics showed that all Moringa leaf cereal formulas had good flow characteristics. The results of the evaluation of cereal characteristics after reconstitution showed that cereal granules dispersed quickly (12.58–16.45 seconds), viscosity 73.75 -245 cps, pseudoplastic flow characteristics, and met the pH requirements of food products (5.00-6.00). The results of proximate analysis and metal content showed that all cereal formulas met the SNI requirements for cereal milk (SNI 01-4270-1996) in terms of protein, carbohydrate, ash, lead (Pb), and copper (Cu) content parameters. The most optimal cereal formula is formula 2 because it shows physical characteristics, fat content, carbohydrates, protein, and heavy metals that meet the requirements, as well as crude fiber content (0.76%) which is closest to the requirements (0.7%).
Analisis Biaya dan Manfaat Berbagai Skema untuk Pelayanan Hemodialisis di Rumah Sakit DR. Sitanala Tangerang
Authors: Azizan Nasron , Sutoto  , S. Maryam Mary
Published: October 2022

This research was conducted to review the clinical pathway and the calculation of total cost of hemodialysis services and to see the comparison of cost and benefits of hemodialysis services with the Operational Cooperation system and self-management in RSK DR Sitanala Tangerang in 2017 from 3 (three) Hemodialysis Machine Providers. The total cost of hemodialysis services with the Operational Cooperation system and self-management is the result of direct and indirect cost calculation with a combination of Activity Based Costing (ABC) methods in accordance with outpatient clinical pathways. Total Cost is obtained by summing the multiplication results between each activity cost in the period of 18 months. Revenue is obtained by summing the multiplication of hospital rates to the number of actions or visits of patients in 18 months. The result of the analysis of the benefits of hemodialysis costs turns out that the Operational Cooperation system is more profitable than self-managed.
Pengaruh Strategi Bisnis dan Corporate Social Responsibility terhadap Tax Avoidance dengan Kinerja Laba Sebagai Variabel Moderasi (Studi Empiris pada Perusahaan Jasa Properti, Real Estate dan Konstruksi Bangunan yang Terdaftar di BEI Periode 2015-2019)
Authors: Herianti Eva , Elinda Ritnawati
Published: October 2022

The research aims to analyze the effect of Business Strategy and Corporate Social Responsibility against Tax Avoidance with Earnings Performance Variabel as a moderating variabel. The research is a quantitative study using secondary data in the form of Annual Report of Service Company sektor property, Real Estate, and Building Construction listed on the Indonesia Stock Exchangne (IDX) in 2015-2019. In this research the process of sampling uses purposive sampling with criteria determined by the research. Then produced 27 Service Company sektor property, Real Estate, and Building Construction. The data analysis technique used is multiple linear regression analysis using E-views version 10 as a data analysis tool. The result of this research indicate that Business Strategy have no significant effect on Tax Avoidance with probability value of 0.754 and Earning Performance moderating Business Strategy have no significant effect on Tax Avoidance with probability value of 0.487. Meanwhile Corporate Social Responsbility have a significant effect on Tax Avoidance with probability value of 0.000 and Earning Perfomance strengthen the Corprate Social responsibility on Tax Avoidance wuth probability value of 0.005.
Gerchberg-Saxton Based FIR Filter for Electronic Dispersion Compensation in IM/DD Transmission Part II: Experimental Demonstration and Analysis
Authors: Wu Xiong , Karar Abdullah S. , Zhong Kangping , Gürkan Zeynep Nilhan , Lau Alan Pak Tao , Lu Chao
Published: October 2022

In this article, the first experimental demonstration of a non-iterative electronic dispersion compensation (EDC) solution implemented at the transmitter using a finite impulse response (FIR) filter optimized with the Gerchberg-Saxton (GS) algorithm, is presented, for intensity-modulation and direct- detection (IM/DD) systems. The theoretical framework for the GS FIR filter and preliminary simulations have been presented in Part I of this work. Here, the performance of the GS FIR filter is compared to that of the iterative GS algorithm in the transmissions of 56-Gb/s on-off keying (OOK) over 80 km of single mode fiber (SMF) with a post feed-forward equalizer (FFE) for combating residual inter-symbol interference (ISI). Furthermore, the influence of the pulse shape (raised cosine or rectangular) and modulation format (return-to-zero (RZ) or non- return-to-zero (NRZ)) on the measured bit error ratio (BER) is experimentally investigated, while changing the number of FIR taps, the number of post-FFE taps, and the number of post-FFE samples-per-symbol. It is shown that within the range of the target digital extinction ratios (DERs) for which the original iterative GS algorithm offers benefit, both analytical and numerical methods for calculating the optimum FIR taps, outlined in Part I of this work, produce similar BER performance as predicted. To that end, the former method is extended, here, through a non-recursive frequency response formula, which offers insight into the action of the GS filter with different pulse shaping and enables the derivation of the explicit GS impulse response. It is also shown that rectangular RZ pulse shaping exploits the full benefit of GS filtering through a uniform spectrum, enabling a BER below the 7% hard-decision forward error correction (HD-FEC) limit, with a 641-tap T/2-spaced pre-EDC FIR filter and a 3-tap adaptive T-spaced post-FFE. 
Quantifying the Complexity of Modeling Power Magnetic Material Characteristics
Authors: Chen Minjie
Published: October 2022

Core losses and hysteresis loops are critical information in the design process of power magnetics, yet the physics behind core loss and hysteresis loops are not fully understood. Core losses and hysteresis loops change for each magnetic material, are highly nonlinear, and depend heavily on the electrical operating conditions (e.g., waveform, frequency, amplitude, dc bias) and the mechanical properties (e.g. pressure, vibration), as well as temperature, and geometry of the magnetic components. Understanding the complexity of these factors is important for the development of accurate models, in addition to addressing the applicability and limitations of each model. Existing studies on power magnetics are usually developed based on a small amount of data and do not reveal the full magnetic behavior across a wide range of operating conditions. In this paper, based on a recently developed large-scale open-source database - MagNet - the core losses and hysteresis loops of Mn-Zn ferrites are analyzed in a wide range of amplitudes, frequencies, waveform shapes, dc bias, and temperatures, to quantify the complexity of modeling magnetic core losses and hysteresis loops and provide guidelines for modeling power magnetics with data-driven methods.
MetaFed: Population-Based Meta Federated Learning Framework for Edge Intelligence
Authors: THAR KYI , Pandey Shashi Raj , Munir Md. Shirajum , Gidlund Mikael , Abedin Sarder Fakhrul , Huh Eui-Nam , Park Seong-Bae , Hong Choong Seon
Published: October 2022

The immediate adoption of deep learning models into domain-specific tasks for edge intelligence-based services still poses several challenges to overcome. The first is efficiently constructing the most suitable neural network architecture amongst the numerous types of available architectures. Once addressing this challenge, the second is understanding how to gather knowledge to build efficient neural network models from the user's devices (i.e., smartphone) without affecting the user's privacy. And the third critical issue is minimizing the gap between estimated and actual performance while building models. In this work, we propose a novel framework for deploying deep learning models for domain-specific tasks called MetaFed, which combines population-based meta-learning and federated learning to resolve the three challenges mentioned earlier. MetaFed autonomously constructs the potential domain-specific models with the help of population-based meta-learning by utilizing the model knowledge base. We improve the model knowledge base by using the population's knowledge via federated learning while minimizing the performance estimation gap for model construction. Experimental results show that our proposed framework offers a promising solution for deploying deep learning models at edge devices, with a significant performance gain than the existing alternative approaches.
MetaFed: Population-Based Meta Federated Learning Framework for Edge Intelligence
Authors: THAR KYI , Pandey Shashi Raj , Gidlund Mikael , Abedin Sarder Fakhrul , Huh Eui-Nam , Park Seong-Bae , Hong Choong Seon
Published: October 2022

The immediate adoption of deep learning models into domain-specific tasks for edge intelligence-based services still poses several challenges to overcome. The first is efficiently constructing the most suitable neural network architecture amongst the numerous types of available architectures. Once addressing this challenge, the second is understanding how to gather knowledge to build efficient neural network models from the user's devices (i.e., smartphone) without affecting the user's privacy. And the third critical issue is minimizing the gap between estimated and actual performance while building models. In this work, we propose a novel framework for deploying deep learning models for domain-specific tasks called MetaFed, which combines population-based meta-learning and federated learning to resolve the three challenges mentioned earlier. MetaFed autonomously constructs the potential domain-specific models with the help of population-based meta-learning by utilizing the model knowledge base. We improve the model knowledge base by using the population's knowledge via federated learning while minimizing the performance estimation gap for model construction. Experimental results show that our proposed framework offers a promising solution for deploying deep learning models at edge devices, with a significant performance gain than the existing alternative approaches.
Robust Subspace Tracking With Contamination Mitigation via α-Divergence
Authors: Thanh Le Trung , Miri Rekavandi Aref , SEGHOUANE ABD-KRIM , abed-meraim karim
Published: October 2022

 We studied the problem of robust subspace tracking (RST) in contaminated environments. Leveraging the fast approximated power iteration and α-divergence, a novel robust algorithm called αFAPI was developed for tracking the underlying principal subspace of streaming data over time. αFAPI is fast and it outperforms many RST methods while only having a low complexity linear to the data dimension. Some experiments were conducted to illustrate the performance of αFAPI.  
Organizational Culture and Corporate Performance: A Review
Authors: Christopher Obah Amechi , Edwinah Amah
Published: October 2022

The study was to examine the relationship between organizational culture and corporate performance. It examines the way organizational culture influences corporate performance in companies. The study employs four elements of organizational culture mode (a) involvement (b) consistency (c) adaptability, and (d) mission. The establishment and upkeep of a successful organizational culture within the organization depends on the four components of the organizational culture model. The specific objective was to: evaluate the relationship between involvement and corporate performance and to assess the relationship between mission and corporate performance. The Denison model was used to examine the operational metrics for measuring organizational culture and corporate success. The research shows a statistically significant link between business performance and organizational culture. Additionally, engagement, adaptability, consistency, and mission impact the organization's non-financial performance. While training demonstrates the strongest association with organizational culture, involvement is the censorious aspect affecting how organizational culture affects corporate performance. This study concluded that lack of effective organizational culture is a primary cause of poor performance and productivity in the corporate organization. The relevance of an effective organizational culture must therefore be understood by company managers if they are to increase performance and productivity in the corporate setting. It was recommended among others that, there should be training for managers and employees on some principles that are important for effective performance. The conceptual underpinning for the investigation was provided by the Denison organizational culture model. The finding of the study included a well-defined mission that attribute to developing shared understanding between employees and managers and employee-focused leadership that contributed to motivating employees. The well-being of society through self-regulatory corporate social responsibility was one of the core corporate value findings. The finding single out in this study cloud have prospects for economic development in the local economy and may subscribe to social change with strategies business and improve the life standards of employees and the local community.
The Relationship Between Self-Concept and Anxiety In Facing The Future on Narcotics Prisoners In Class II a Drawing Institutions, Muara Beliti
Authors: Nisa Khoiru , Nugroho Arista Adi , Kusumawati Rafika Nur
Published: October 2022

This research is a quantitative research with the goal to be achievedis to find a relationship between anxiety facing the future with self-concept in narcotics prisoners in Class IIA Narcotics Prison Muara Beliti. The research data was collected using the self-concept scale and the anxiety scale in facing the future with 88 samples of Narcotics Prisoners. Simple random sampling was used as a sampling technique in this study. The hypothesis was tested using the Peorson Product Moment Correlation technique. The results of the hypothesis test show the value of Sig. (2-tailed) between self-concept and anxiety in dealing with narcotics inmates at the Class IIA Narcotics Prison Muara Beliti is 0.00 <0.05, which means there is a significant correlation between self-concept variables and anxiety variables in facing the future at narcotics inmates at the Class IIA Narcotics Prison in Muara Beliti. Furthermore, based on the Pearson correlation value, it is known that the calculated r value for the relationship between self-concept and anxiety in facing the future is 0.453 > r table (0.209). Thus, it can be concluded that there is a relationship or correlation between the self-concept variable and the anxiety variable in facing the future in narcotics prisoners at the Class IIA Narcotics Prison Muara Beliti.
Utilization of Drug Delivery Technologies & Screening in Present Day Drug Development and Discovery
Authors: Musthafa Jezila , Sravani Bodipudi
Published: October 2022

In this following thesis the technologies that offer an effectiveness and efficiency during drug delivery will be discussed in an explained and detailed way. Drug delivery can be considered towards the engagement in order to manufacture systems, formulation, storage systems or inventory and other critical technologies that can offer sufficient work efficiency and smoothness in the area of transporting towards the destined site. This essential movement provides desired therapeutic effects in requirement of drug development and delivering a pharmaceutical compound towards the target area. Keyword : — Drug, Drug development, Technologies, Pharmaceutical, transportation
Role of Financial Innovation in Achieving Economic Sustainability: A Review Study
Authors: Gerged Ali Meftah
Published: October 2022

Financial innovation accelerates the economic sustainability of firms by enhancing financial markets’ productivity, accelerating capital development, improving financial services, and creating more effective financial intermediation. This article, therefore, highlights the possible economic performance associated with applying different methods of financial innovation. Employing a desk study methodology, this paper discusses the effectiveness of financial innovation techniques in enhancing firms’ economic sustainability performance theoretically. In doing so, this review paper provides policymakers and practitioners with several insights into the efficiency of such strategies for businesses’ sustainable economic growth. Abstract: Economic Sustainability, Exchanged-traded funds, Financial innovation, Hedge funds, private equity, weather derivative.
СТАТИСТИЧНЕ МОДЕЛЮВАННЯ ТЕХНІЧНИХ ХАРАКТЕРИСТИК МЕТАЛОРІЗАЛЬНИХ ВЕРСТАТІВ
Authors: Четвержук Т.І. , Полінкевич Р.М. , Редько Р.Г. , Залета О.М. , Скляров Р.А.
Published: October 2022

Проведено комплексний розгляд математичних моделей верстатних елементів на різних рівняхпроектування, включаючи питання отримання математичних моделей і їх реалізації на ЕОМ з метоювдосконалення технічних характеристик металорізальних верстатів та розширення технологічнихможливостей оброблення деталей.
АНАЛІЗ КОНСТРУКЦІЙ ТА РОБОТИ ПІДБИРАЛЬНИХ АПАРАТІВ МАШИН ДЛЯ ЗБИРАННЯ ЛЬОНУ
Authors: Чайка О.О. , Толстушко Н.О. , Толстушко М.М. , Сацюк В.В. , Булік Ю.В.
Published: October 2022

В статті проаналізовано конструкції та роботу підбиральних апаратів машин для збирання льону, виявлено їх недоліки та окреслити шляхи удосконалення цих апаратів для поліпшення якості підбирання стрічкистебел льону. Якість роботи підбиральних апаратів льонозбиральних машин оцінювалась за виконаннямвстановлених агротехнічних вимог. Представлено загальну класифікацію підбиральних апаратів машин за їхфункціональним призначенням та конструктивним виконанням.
ЗНАЧЕННЯ СТАНДАРТИЗАЦІЇ У ІННОВАЦІЙНИХ ПРОЦЕСАХ
Authors: Павлиго Т.М.
Published: October 2022

Проаналізовано вплив стандартизації на інноваційні процеси та визначено загальні механізми такого впливу.