bluuebunny/crossref_metadata_2025 huggingface dataset:
Infant liver biochemistry is different than current laboratory accepted norms
Authors: Kolho Kaija-Leena , Lahtiharju Tapio , Merras-Salmio Laura , Pakarinen Mikko P. , Knip Mikael
Published: October 2023

The purpose is to study liver biochemistry in a well-defined cohort of term infants. The methods include healthy term infants (n = 619) provided blood samples at 3 and 6 months of age when participating to the DIABIMMUNE study. The infants were followed up at clinical study visits 3, 6, 12, 18, 24, and 36 months the participation rate being 88.6% at the end of follow-up, while none disclosed any signs of a liver disease. The serum levels of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), total bilirubin (BIL), and conjugated bilirubin (BIL-conj) were determined using Siemens Atellica CH 930 analyzers. The results are at 3 months of age, the upper 90% CI for ALT, AST, ALP, GGT, BIL, and BIL-conj were higher than the current upper reference limits in our accredited hospital laboratory. At 6 months, the upper 90% CIs for ALT had declined but was still higher than the cut-offs for a raised value. The upper 90% CI for AST remained as high as at 3 months, whereas ALP, BIL-conj, and GGT had decreased close to the current cut-offs. The type of feeding was associated with the levels of liver biochemistry. Exclusively or partially breastfed infants showed higher ALT, AST, BIL, and BIL-conj values at 3 months than formula-fed. Breastfed infants had higher AST, Bil, and Bil-conj values also at 6 months.

  Conclusion: We encourage setting appropriate reference ranges for liver biochemistry for the first year of life and to note the type of feeding.

What is Known:• Healthy infants may show higher values of liver biochemistry during their first year of life than in later life.• It has been speculated that type of feeding may play a role in liver biochemistry levels among infants.

What is New:• In a cohort of healthy infants, several analytes of liver biochemistry were higher than the currently used upper reference limits at 3 and 6 months of age, and exclusively or partially breastfed infants showed higher values than formula-fed.• The findings address the importance of setting appropriate reference ranges for liver biochemistry for the first year of life.
Investigating the cell membrane localization of PADI4 in breast cancer cells and inhibition of anti-PADI4 monoclonal antibody
Authors: Wang Yan , Song Xianqin , Song Yu , Fang Kehua , Chang Xiaotian
Published: October 2023

Background

Peptidyl arginine deiminase 4 (PADI4) is a post-translational modification enzymecan that converts arginine in protein into citrulline in the presence of calcium ions, which is called citrullination. PADI4 has been reported to be expressed in the cytoplasm and nucleus in a variety of malignant tumors. Based on the GeneCards database and our previous research, it is speculated that PADI4 may also be expressed on the cell membrane. This study aimed to confirm the membrane expression of PADI4 and the effect of anti-PADI4 antibodies on cell membrane PADI4. This may be another mechanism of action of anti-PADI4 monoclonal antibodies in the treatment of breast cancer.

Methods

The subcellular localizations of PADI4 in MDA-MB-231 and MCF-7 breast cancer cells were determined by immunofluorescence, immunoelectron microscopy, and Western blot analysis. The tumor cells were treated with PADI4 antibody, and cell proliferation, migration, colony formation, apoptosis, glycolysis, and epithelial-mesenchymal transition (EMT) were measured as well as the expression of some essential tumor genes.

Results

PADI4 was not only localized in the nucleus and cytoplasm of breast cancer cells but was also detected on the cell membrane. Following PADI4 antibody treatment, cell proliferation, migration, colony formation, EMT, and ATP production through glycolysis were decreased, and the mRNA expression of MYC proto-oncogene (MYC), FAT atypical cadherin 1 (FAT1), nuclear factor kappa B subunit 1 (NFκB), and tumor necrosis factor (TNF-α) in breast cancer cells was downregulated, while the mRNA expression of tumor protein p63 (TP63) was upregulated.

Conclusions

PADI4 is expressed on the cell membrane in breast cancer cells. Anti-PADI4 antibodies can affect the biological functions of cell membrane PADI4, including proliferation, migration, apoptosis, and glycolysis, thereby inhibiting tumor progression.

Graphical abstract
Periodic Steiner Networks Minimizing Length
Authors: Alex Jerome , Grosse-Brauckmann Karsten
Published: October 2023

We study a problem of geometric graph theory: We determine the triply periodic graph in Euclidean 3-space which minimizes length among all graphs spanning a fundamental domain with the same volume. The minimizer is the so-called network with quotient the complete graph on four vertices $$K_4$$

K
4

. For comparison we consider a competing topological class, also with a quotient on four vertices, and determine the minimizing networks.
Dye-free visualisation of intestinal perfusion using laser speckle contrast imaging in laparoscopic surgery: a prospective, observational multi-centre study
Authors: Heeman Wido , Calon Joost , van der Bilt Arne , Pierie Jean-Pierre E. N. , Pereboom Ilona , van Dam Gooitzen M. , Boerma E. Christiaan
Published: October 2023

Introduction

Intraoperative perfusion imaging may help the surgeon in creating the intestinal anastomoses in optimally perfused tissue. Laser speckle contrast imaging (LSCI) is such a perfusion visualisation technique that is characterized by dye-free, real-time and continuous imaging. Our aim is to validate the use of a novel, dye-free visualization tool to detect perfusion deficits using laparoscopic LSCI.

Methods

In this multi-centre study, a total of 64 patients were imaged using the laparoscopic laser speckle contrast imager. Post-operatively, surgeons were questioned if the additional visual feedback would have led to a change in clinical decision-making.

Results

This study suggests that the laparoscopic laser speckle contrast imager PerfusiX-Imaging is able to image colonic perfusion. All images were clear and easy to interpret for the surgeon. The device is non-disruptive of the surgical procedure with an average added surgical time of 2.5 min and no change in surgical equipment. The potential added clinical value is accentuated by the 17% of operating surgeons indicating a change in anastomosis location. Further assessment and analysis of both white light and PerfusiX perfusion images by non-involved, non-operating surgeons showed an overall agreement of 80%.

Conclusion

PerfusiX-Imaging is a suitable laparoscopic perfusion imaging system for colon surgery that can visualize perfusion in real-time with no change in surgical equipment. The additional visual feedback could help guide the surgeons in placing the anastomosis at the most optimal site.
Characteristic of bioclimatic conditions in Poland based on Physiologically Equivalent Temperature
Authors: Tomczyk Arkadiusz M. , Matzarakis Andreas
Published: October 2023

The aim of the study was to characterise bioclimatic conditions in Poland in the times of progressing warming. This type of research permits the verification whether the progressing climate warming also translates into a change in bioclimatic conditions. This study was based on data obtained for the period 1966–2021 from 37 synoptic stations located in Poland. All the data series were uniform and obtained from the data base of the Institute of Meteorology and Water Management—National Research Institute (IMGW-PIB). The study revealed high variability of bioclimatic conditions in Poland both in spatial and in temporal terms. The lowest mean annual PET values were recorded in the north and north-east of the country and the highest in the south-west of Poland. The study revealed changes in the frequency of occurrence of days with cold and heat stress, as well as days with no thermal stress. The most intensive changes were determined for days with cold stress. A decrease in the number of days in this category translated into an increase in the number of days with no thermal stress and days with heat stress.
Predictors for spinal deformity following resection of intramedullary tumor via posterior approach: a systematic review and meta-analysis
Authors: Szyduczyński Maciej , Korneliussen Johannes , Landé Oscar , Krakowiak Michał , Szmuda Tomasz , Miękisiak Grzegorz
Published: October 2023

Purpose

The present study aimed to identify the clinical predictive factors for worsened spinal deformity (SD) following surgical resection via posterior approach for primary intramedullary tumors.

Methods

A systematic search was performed using PubMed, Web of Science, and Scopus databases to extract potential references. Observational studies reporting predictive factors for worsened SD following surgical resection via posterior approach for primary intramedullary tumors were included. The odds ratio (OR) was calculated for dichotomous parameters.

Results

Four retrospective cohort studies were included in the meta-analysis. They were comprised of two groups of patients; those who developed SD (n = 87) and those who did not (n = 227). For patients with IMSCTs, age under 25 years as well as age under 13 years were the demographic variables associated with postoperative SD (odds ratio [OR] 3.92; p = 0.0002 and OR 4.22; p = 0.003). In both the fusion and the non-fusion subgroups, preoperative spinal deformity strongly predicted postoperative SD (OR 11.94; p < 0.001), with the risk highly elevated among the non-fusion patients (OR 24.64; p < 0.0002). Thoracolumbar junction involvement was also found to be a predictor of postoperative SD for patients with IMSCT (OR 2.89; p = 0.02).

Conclusion

This study highlights the importance of considering age, preoperative spinal deformity, and thoracolumbar junction involvement as predictors of postoperative spinal deformity following surgical resection for IMSCT. These findings may provide guidance for the management of these patients, including the development of preoperative planning strategies and the selection of the most appropriate surgical approach for high-risk patients.
Targeted muscle reinnervation in upper extremity amputations
Authors: Le Elliot L. H. , Iorio Matthew L. , Greyson Mark A.
Published: October 2023

Purpose

Targeted muscle reinnervation (TMR) is a relatively recent surgical innovation that involves the coaptation of major peripheral nerves to a recipient motor branch that innervates an expendable muscle target. The original indication for TMR was augmentation and optimization of myoelectric signals in the amputated limb for use of myoelectric prosthetics. Incidentally, surgeons and patients discovered that the technique also could treat and prevent phantom and residual limb pain. TMR is performed at the time of amputation or delayed any time after the amputation, and TMR can also be performed at any level of amputation. In the upper extremity, studies have detailed the various techniques and coaptations possible at each amputation level to create intuitive myoelectric signals and treat neurogenic pain. Treatment of peripheral nerves in the amputee with TMR should be a consideration for all patients with major upper extremity amputations, especially at large institutions able to support multidisciplinary limb salvage teams. This review article summarizes the current literature and authors’ techniques and recommendations surrounding TMR in the upper extremity amputee including techniques relevant to each level of upper extremity amputation.
Facial emotion expressivity in patients with Parkinson’s and Alzheimer’s disease
Authors: Cannavacciuolo Antonio , Paparella Giulia , Salzillo Martina , Colella Donato , Canevelli Marco , Costa Davide , Birreci Daniele , Angelini Luca , Guerra Andrea , Ricciardi Lucia , Bruno Giuseppe , Berardelli Alfredo , Bologna Matteo
Published: October 2023

Parkinson’s disease (PD) and Alzheimer’s disease (AD) are neurodegenerative disorders with some overlapping clinical features. Hypomimia (reduced facial expressivity) is a prominent sign of PD and it is also present in AD. However, no study has experimentally assessed hypomimia in AD and compared facial expressivity between PD and AD patients. We compared facial emotion expressivity in patients with PD, AD, and healthy controls (HCs). Twenty-four PD patients, 24 AD patients and 24 HCs were videotaped during neutral facial expressions and while posing six facial emotions (anger, surprise, disgust, fear, happiness, and sadness). Fifteen raters were asked to evaluate the videos using MDS-UPDRS-III (item 3.2) and to identify the corresponding emotion from a seven-forced-choice response format. We measured the percentage of accuracy, the reaction time (RT), and the confidence level (CL) in the perceived accuracy of the raters’ responses. We found the highest MDS-UPDRS 3.2 scores in PD, and higher in AD than HCs. When evaluating the posed expression captures, raters identified a lower percentage of correct answers in the PD and AD groups than HCs. There was no difference in raters’ response accuracy between the PD and AD. No difference was observed in RT and CL data between groups. Hypomimia in patients correlated positively with the global MDS-UPDRS-III and negatively with Mini Mental State Examination scores. PD and AD patients have a similar pattern of reduced facial emotion expressivity compared to controls. These findings hold potential pathophysiological and clinical implications.
The effect of parenting behaviours on adolescents’ rumination: a systematic review of longitudinal studies
Authors: Castro Tiago , Pinto Tiago Miguel , Morais Ana , Costa Raquel , Jongenelen Inês , Lamela Diogo
Published: October 2023

Rumination is an emotional regulation mechanism strongly associated with the development and maintenance of internalising psychopathology in adolescence and adulthood. Parenting behaviours (PBs) play a pivotal role in the development of rumination in children and adolescents. Nonetheless, the specific PBs that can either protect against or increase the risk of rumination development remain poorly understood. This systematic review aimed to explore the (1) temporal associations between PBs and adolescents’ rumination and (2) potential moderators influencing these associations. We conducted a comprehensive search across Web of Science, Scopus, PubMed, Academic Search Complete and Eric databases, adhering to PRISMA reporting guidelines. Out of 1,868 abstracts screened, 182 articles underwent full-text examination, with nine meeting the inclusion criteria for the systematic review. Overall, the studies indicated that PBs characterised by criticism, rejection and control were positively associated with the development of rumination in adolescents, whilst PBs marked by authoritative practises exhibited a negative association with rumination. Gender, temperament, environmental sensitivity and pubertal timing emerged as significant moderators in the effects of PBs on rumination. However, conclusions were limited due to the studies’ methodological heterogeneity. Future studies on PBs and rumination should address various dimensions of PBs and different moderators to identify factors that can modify the development of rumination across adolescence. Findings may inform family-based prevention programmes to promote emotion regulation in adolescents as a protective factor against internalising psychopathology across adulthood.
Preconditioning of discrete state- and control-constrained optimal control convection-diffusion problems
Authors: Dravins Ivo , Neytcheva Maya
Published: October 2023

We consider the iterative solution of algebraic systems, arising in optimal control problems constrained by a partial differential equation with additional box constraints on the state and the control variables, and sparsity imposed on the control. A nonsymmetric two-by-two block preconditioner is analysed and tested for a wide range of problem, regularization and discretization parameters. The constraint equation characterizes convection-diffusion processes.
eGFR slope as a surrogate endpoint for end-stage kidney disease in patients with diabetes and eGFR > 30 mL/min/1.73 m2 in the J-DREAMS cohort
Authors: Sugawara Yuka , Kanda Eiichiro , Ohsugi Mitsuru , Ueki Kohjiro , Kashihara Naoki , Nangaku Masaomi
Published: October 2023

Background

An analysis of European and American individuals revealed that a reduction in estimated glomerular filtration rate (eGFR) slope by 0.5 to 1.0 mL/min/1.73 m2 per year is a surrogate endpoint for end-stage kidney disease (ESKD) in patients with early chronic kidney disease. However, it remains unclear whether this can be extrapolated to Japanese patients.

Methods

Using data from the Japan diabetes comprehensive database project based on an advanced electronic medical record system (J-DREAMS) cohort of 51,483 Japanese patients with diabetes and a baseline eGFR ≥ 30 mL/min/1.73 m2, we examined whether the eGFR slope could be a surrogate indicator for ESKD. The eGFR slope was calculated at 1, 2, and 3 years, and the relationship between each eGFR slope and ESKD risk was estimated using a Cox proportional hazards model to obtain adjusted hazard ratios (aHRs).

Results

Slower eGFR decline by 0.75 mL/min/1.73 m2/year reduction in 1-, 2-, and 3-year slopes was associated with lower risk of ESKD (aHR 0.93 (95% confidence interval (CI) 0.92–0.95), 0.84 (95% CI 0.82–0.86), and 0.77 (95% CI 0.73–0.82), respectively); this relationship became more apparent as the slope calculation period increased. Similar results were obtained in subgroup analyses divided by baseline eGFR or baseline urine albumin-creatinine ratio (UACR), with a stronger correlation with ESKD in the baseline eGFR < 60 mL/min/1.73 m2 group and in the baseline UACR < 30 mg/gCre group.

Conclusion

We found that changes in the eGFR slope were associated with ESKD risk in this population.
Diagnostic biopsy does not accurately reflect the PD-L1 expression in triple-negative breast cancer
Authors: Zdrenka Marek , Kowalewski Adam , Borowczak Jędrzej , Łysik-Miśkurka Joanna , Andrusewicz Hanna , Nowikiewicz Tomasz , Szylberg Łukasz
Published: October 2023

PD-L1 expression is known to predict the benefits of immune checkpoint inhibitor therapy for triple-negative breast cancer (TNBC). We examined whether the PD-L1 expression evaluated in biopsy specimens accurately reflects its expression in the whole tumor. Immunohistochemistry was performed on 81 biopsy and resection specimens from patients with TNBC to determine their PD-L1 status. We found PD-L1-positive tumors in 23 (28%) biopsy specimens and primarily PD-L1-negative tumors in 58 (72%). The PD-L1 status was reevaluated in matching postoperative specimens of primarily PD-L1-negative tumors. Of them, 31% (18/58) were positive, whereas 69% (40/58) were negative. Considering the pre- and postoperative analyses, 41 (51%) patients had PD-L1-positive tumors, while 40 had PD-L1-negative tumors. We found 18 (22%) more PD-L1-positive tumors while examining the resection specimens compared to biopsies, and the difference was statistically significant (p = 0.0038). Diagnostic biopsies do not fully reflect the PD-L1 expression in TNBC. Our results suggest that a significant subset of TNBC patients may be misclassified as PD-L1-negative and disqualified from anti-PD-L1 therapy.
Improved crop productivity and soil properties under varying planting densities of Pentaclethra macrophylla Benth. and Acacia auriculiformis A. Cunn. in Congo Basin
Authors: Mapenzi Neville , Katayi Alain L. , Bauters Marijn , Masimane Jules , Schure Jolien , Kweyu Raphael , Nabahungu Nsharwasi L.
Published: October 2023

Soil fertility depletion is a major constraint to agricultural production in the Congo Basin and is aggravated by climate change. Therefore, agroforestry systems (AFS) are used to improve soil fertility and crop productivity. Indeed,Pentaclethra macrophyllaandAcacia auriculiformisare among the most agroforestry species used in this basin. However, smallholders are limited in their choice of agroforestry species and the spacing. Hence, this study comparatively evaluated the effects ofP. macrophylla(native) andA. auriculiformis(exotic) legume tree species on soil macronutrients and food crops’ yield during four cropping seasons. To do this, a multifactor trial design was implemented in Lobilo catchment, Congo Basin, with two tree species, four tree planting densities (T1: 2500 trees × ha−1, T2: 625 trees × ha−1, T3: 278 trees × ha−1; and T0: crop monoculture), and three intercrops (cassava, maize, and peanut). The results revealed that both agroforestry species did not significantly differ regarding their impact on soil macronutrients. The total nitrogen and the pH in soil have increased with the cropping seasons. With regard to the food crops, cassava and maize yield were greater underP. macrophyllathan underA. auriculiformis.However, the 2500 trees × ha−1density negatively affected food crops’ yield and did not allow food crop production after the second cropping season. To maximize the positive effects of these AFS, it is essential to plant or co-plant these two agroforestry species at 625 trees × ha−1density. Future research could investigate other native species and include water and light interactions.
Assessing concrete nest boxes for cavity-nesting bees
Authors: Henry Mickaël , Berrou Pierre-Jules , Bourdon Sarah , Guilbaud Laurent , Vaissière Bernard E.
Published: October 2023

Artificial nest boxes for solitary bees and other cavity-nesting Hymenoptera are increasingly used for a variety of purposes, including ecological research, crop pollination support and public outreach. Their attractivity and colonization success by cavity-nesting solitary bees depend on their design and placement, including hole dimensions, orientation and the neighboring habitats and available resources. While most bee nest boxes are made of wooden materials, we assessed here the suitability of perennial, concrete nest boxes for cavity-nesting bees. We carried out a three-year nesting survey of 52 custom-made nest boxes located in 11 different sites throughout France and totaling 2912 available holes of 6, 8, 10 or 12 mm in diameter. Concrete nest boxes successfully attracted reproductive females of solitary bee species and supported successful larval development until the emergence of new individuals. Preferred cavities were the smallest ones (6-8 mm), located at the lowest tested positions above ground (31-47 cm) and oriented southward. Local bee populations established in nest boxes steadily increased throughout the three successive seasons in nearly all study sites. The cavity-nesting bee communities were mostly composed of rather common and generalist species, but also comprised a foraging specialist. Additionally, two cleptoparasitic bee species were detected. All species belonged to the Megachilidae. We further discuss the effects of neighboring urban and natural habitats as potential source or sink of nesting bees, as well as opportunities of concrete nest boxes as tools for urban agriculture and more generally for the new biomimetic urban designs to restore local ecosystem services in cities.
Patient Knowledge and Trust in Health Care. A Theoretical Discussion on the Relationship Between Patients’ Knowledge and Their Trust in Health Care Personnel in High Modernity
Authors: Conradsen Stein , Vardinghus-Nielsen Henrik , Skirbekk Helge
Published: October 2023

In this paper we aim to discuss a theoretical explanation for the positive relationship between patients’ knowledge and their trust in healthcare personnel. Our approach is based on John Dewey’s notion of continuity. This notion entails that the individual’s experiences are interpreted as interrelated to each other, and that knowledge is related to future experience, not merely a record of the past. Furthermore, we apply Niklas Luhmann’s theory on trust as a way of reducing complexity and enabling action. Anthony Giddens’ description and analysis of the high modern society provides a frame for discussing the preconditions for patient-healthcare personnel interaction. High modernity is dominated by expert systems and demands trust in these. We conclude that patient knowledge and trust in healthcare personnel is related because both knowledge and trust are future- and action-oriented concepts. The traits of high modernity provides opportunities and challenges as the personnel can and must perform discretion. This discretion must be made in a context where knowledge is considered uncertain and preliminary.
Finitary Type Theories With and Without Contexts
Authors: Haselwarter Philipp G. , Bauer Andrej
Published: October 2023

We give a definition of finitary type theories that subsumes many examples of dependent type theories, such as variants of Martin–Löf type theory, simple type theories, first-order and higher-order logics, and homotopy type theory. We prove several general meta-theorems about finitary type theories: weakening, admissibility of substitution and instantiation of metavariables, derivability of presuppositions, uniqueness of typing, and inversion principles. We then give a second formulation of finitary type theories in which there are no explicit contexts. Instead, free variables are explicitly annotated with their types. We provide translations between finitary type theories with and without contexts, thereby showing that they have the same expressive power. The context-free type theory is implemented in the nucleus of the Andromeda 2 proof assistant.
Influence of polydopamine and tannic acid coatings on thermal properties of polylactide
Authors: Moraczewski Krzysztof , Szabliński Krzysztof
Published: October 2023

In this paper, the research findings about the impact of polydopamine and tannic acid coatings on specific thermal properties of polylactide are discussed. The influence of deposited coatings on the resistance to oxidation, heat resistance, and the temperatures of phase transitions was determined. Therefore, the oxidation induction temperature, thermogravimetry, and differential scanning calorimetry studies were carried out. To gain a deeper understanding of the findings, mass measurements for the samples before and after the deposition process were conducted, as well as scanning electron microscopy studies. Studies have shown that the application of coatings can improve the resistance of polylactide against oxidative and thermal degradation. However, these coatings have minimal impact on the intensity and temperature of phase transformations. The polylactide showed increased thermal resistance when coated with polydopamine, whereas tannic acid coating was found to be more effective in increasing oxidation resistance. The differences observed were likely caused by variations in the structure of the coatings applied, impacting the level of oxygen diffusion and heat transfer within the material.
Evaluating the environmental performance of mezcal production in Michoacán, México: A life cycle assessment approach
Authors: Ruiz-Camou César , Núñez José , Musule Ricardo
Published: October 2023

Purpose

The purpose of this work is to evaluate the environmental impacts of mezcal production from Agave cupreata in Michoacán, México. The central question is the influence of management options for vinasse, bagasse, and biomass energy.

Methods

The study was conducted using life cycle assessment (LCA) based on the conceptual framework of ISO 14040, guidelines of ISO 14044, and material and energy flow analysis, in a cradle-to-gate approach. The functional unit considered is a packaged mezcal of 0.75 ls produced in compliance with the official Mexican standard for this type of alcoholic beverage. Site measurements were conducted at two agave processing facilities, and descriptive surveys were carried out in collaboration with local producers. Related ecoefficiency indicators were evaluated and shown in a transparent and reproducible way. Environmental impact categories such as global warming potential (GWP), fine particulate matter formation (PMFP), freshwater eutrophication (FEP), and cumulative energy demand (CED) were calculated.

Results

The results indicate that bioenergy is 87% of the cumulative energy for production. The main source of impacts from the PMFP category was the distillation process (50%). The vinasse contribution is around 60.4% for the FEP category. Bagasse’s contribution to the GWP category is around 22.7%. Even though carbon dioxide produced from biomass is considered biogenic, the overall impact is still significant due to the presence of other compounds such as methane. We also evaluate barriers to the implementation of alternative waste management technologies for bagasse and vinasse.

Conclusions

From this study, it is concluded that biomass energy plays a crucial role in the sustainable manufacturing of mezcal.
Segregation between the parietal memory network and the default mode network: effects of spatial smoothing and model order in ICA
Authors: Hu Yang , Wang Jijun , Li Chunbo , Wang Yin-Shan , Yang Zhi , Zuo Xi-Nian
Published: October 2023

A brain network consisting of two key parietal nodes, the precuneus and the posterior cingulate cortex, has emerged from recent fMRI studies. Though it is anatomically adjacent to and spatially overlaps with the default mode network (DMN), its function has been associated with memory processing, and it has been referred to as the parietal memory network (PMN). Independent component analysis (ICA) is the most common data-driven method used to extract PMN and DMN simultaneously. However, the effects of data preprocessing and parameter determination in ICA on PMN–DMN segregation are completely unknown. Here, we employ three typical algorithms of group ICA to assess how spatial smoothing and model order influence the degree of PMN–DMN segregation. Our findings indicate that PMN and DMN can only be stably separated using a combination of low-level spatial smoothing and high model order across the three ICA algorithms. We thus argue for more considerations on parametric settings for interpreting DMN data.
Are some morphological units more prone to spelling variation than others? A case study using spontaneous handwritten data
Authors: Berg Kristian , Hartmann Stefan , Claeser Daniel
Published: October 2023

The relation between morphology and spelling is an important source of evidence for theories of linguistic processing. In particular, spelling errors can help us assess the role of morphological structure in language users’ mental representations of words in authentic texts. Previous research suggests that some morphological units are more prone to spelling errors than others, partly depending on the degree to which they are perceived as separate units. In this paper, we want to test this hypothesis by exploring graphemic variation in a collection of 1,667 German school-exit exams. Specifically, we code the spelling errors for their morphological structure. We can show that inflectional suffixes show a much higher probability of final letter omissions compared to final stems or derivational suffixes. We also find tentative evidence that case markers are more often affected by omissions than number markers.
Effect of Surgically Induced Weight Loss on Pelvic Organ Prolapse: A Meta-analysis
Authors: Tian Zhao , Wang Xiuqi , Hu Xiaopeng , Sun Zhijing
Published: October 2023

Introduction

Bariatric surgery alleviates certain aspects of pelvic floor disorder, but the effect on pelvic organ prolapse (POP) is unclear. To assess the effect of bariatric surgery on POP we conducted the present meta-analysis and firstly performed a subgroup analysis based on the duration of follow-up.

Methods

Four databases including PubMed, The Cochrane Library, Web of Science, and Embase were searched to identify relevant studies published before February 24, 2023. The main outcome was the prevalence and severity of POP symptoms before and after bariatric surgery. Then we assessed the heterogeneity, publication bias and performed subgroup analyses based on follow-up time, study quality and region.

Results

Eleven studies with a total of 696 participants met the inclusion criteria. The results showed that the prevalence of POP decreased after bariatric surgery (odds ratio[OR] = 2.29, 95% confidence interval[CI]: 1.05, 5.01; P = 0.04, I2 = 78%), with significant differences observed both at 3–6 months (OR = 2.24, 95% CI: 1.25, 4.01; P = 0.007, I2 = 59%) and 12 months (OR = 4.64, 95% CI: 2.83, 7.58; P < 0.0001, I2 = 0%) of follow-up compared with pre-surgery. Pelvic Organ Prolapse Distress Inventory scores 6-item also decreased after bariatric surgery (mean difference [MD] = 2.11, 95% CI: 0.32, 3.89; P = 0.02, I2 = 55%) with significant differences observed both at 3–6 months (MD = 3.72; 95% CI: [0.10, 7.34], P = 0.04, I2 = 70%) and ≥ 12 months (MD = 3.24; 95% CI: [0.56, 5.91], P = 0.02, I2 = 56%) of follow-up.

Conclusion

Bariatric surgery alleviated POP symptoms in women with obesity both during short-term (3–6 months) and long-term (≥ 12 months) follow-up.

Graphical Abstract
Approach for the monetary evaluation of process innovations in early innovation phases focusing on manufacturing and material costs
Authors: Demke Tabea Marie , Emminghaus Nicole , Overmeyer Ludger , Kaierle Stefan , Klose Christian , Thürer Susanne Elisabeth , Denkena Berend , Bergmann Benjamin , Schaper Florian , Nyhuis Peter , Kuprat Vivian Katharina
Published: October 2023

In early innovation phases, the monetary evaluation of process innovations is a challenge for companies due to a lack of data. However, an innovation evaluation is essential in an early innovation phase to ensure that process innovations deliver economic value added (EVA) in early innovation phases and to channel technology transfer expenditures in a goal-oriented manner. This paper presents an approach for a semi-quantitative procedure for the monetary evaluation of process innovations in the early innovation phase focusing on manufacturing and material costs. Exemplarily, the approach is applied to process innovations of the Collaborative Research Center 1368 on oxygen-free production. In order to ensure the net present value orientation within the innovation evaluation, the procedure developed is based on a driver tree of the EVA. To link value drivers of the EVA and innovation-driven factors influencing EVA, the EVA driver tree is further systematized with a focus on manufacturing and material costs using a literature-based impact model. Based on the last level of the impact model, a guideline for a semi-structured expert interview is developed. Using this interview guideline, data is collected in the form of innovation-driven influencing factors, which represent the input for the final monetary innovation evaluation. An adapted weighted scoring model is used to draw a semi-quantitative conclusion regarding the EVA achieved by the process innovation. The practical application of the approach developed to process innovations in oxygen-free production has shown that, in the context of three process innovations under consideration, their implementation with the aim of achieving an EVA through reduced manufacturing and material costs at the current innovation status is not effective. However, based on the impact model developed, corresponding levers can be identified to positively influence the EVA and thus also the industrialization of the process innovation. Finally, further necessary steps are identified to evolve the presented approach into a complete method for monetary innovation evaluation in early innovation phases.
Hydrogels for Cardiac Restorative Support: Relevance of Gelation Mechanisms for Prospective Clinical Use
Authors: Vetter Valentine C. , Bouten Carlijn V. C. , van der Pol Atze
Published: October 2023

Purpose of Review

Cardiac tissue regenerative strategies have gained much traction over the years, in particular those utilizing hydrogels. With our review, and with special focus on supporting post-myocardial infarcted tissue, we aim to provide insights in determining crucial design considerations of a hydrogel and the implications these could have for future clinical use.

Recent Findings

To date, two hydrogel delivery strategies are being explored, cardiac injection or patch, to treat myocardial infarction. Recent advances have demonstrated that the mechanism by which a hydrogel is gelated (i.e., physically or chemically cross-linked) not only impacts the biocompatibility, mechanical properties, and chemical structure, but also the route of delivery of the hydrogel and thus its effect on cardiac repair.

With regard to cardiac regeneration, various hydrogels have been developed with the ability to function as a delivery system for therapeutic strategies (e.g., drug and stem cells treatments), as well as a scaffold to guide cardiac tissue regeneration following myocardial infarction. However, these developments remain within the experimental and pre-clinical realm and have yet to transition towards the clinical setting.
Homotolerant versus Homophobic? Swedish Sexual Exceptionalism and the Russian Other
Authors: Polkov Kirill
Published: October 2023

This article explores how discourses of LGBTQI rights, homophobia, and homotolerance intersect in specific nation-state contexts. Focusing on Sweden’s self-image of homotolerance, the author shows how this image has depended on the construction of non-tolerant and sexually backward Russia since 1991. This article suggests sexual exceptionalism as a more precise term to understand the relationship between Sweden and Russia in terms of geopolitics of sexuality. To do so, it examines the construction of Russia in the Swedish media discourse, with a focus on the position of LGBTQI people, and analyzes how this discourse, in turn, constructs the Swedish Self as exceptional and tolerant. My conclusions are based on a material consisting of around 500 articles from the five largest Swedish newspapers, published from 1991 to 2019. I show how the Swedish newspapers’ portrayals of attitudes towards the LGBTQI subjects in Russia have relied on constructions of temporal difference and geographical closeness between the two nations and exhibited little change throughout the period. The article contributes to scholarship on global sexualities by demonstrating how the constructions of the homophobic Other become embedded in existing historical discourses on othering by helping produce notions of the sexual-politically exceptional Self.
The Japanese Breast Cancer Society Clinical Practice Guidelines for systemic treatment of breast cancer, 2022 edition
Authors: Terada Mitsuo , Ito Aki , Kikawa Yuichiro , Koizumi Kei , Naito Yoichi , Shimoi Tatsunori , Ishihara Mikiya , Yamanaka Takashi , Ozaki Yukinori , Hara Fumikata , Nakamura Rikiya , Hattori Masaya , Miyashita Minoru , Kondo Naoto , Yoshinami Tetsuhiro , Takada Masahiro , Matsumoto Koji , Narui Kazukata , Sasada Shinsuke , Iwamoto Takayuki , Hosoda Mitsuchika , Takano Yuko , Oba Takaaki , Sakai Hitomi , Murakami Akari , Higuchi Toru , Tsuchida Junko , Tanabe Yuko , Shigechi Tomoko , Tokuda Emi , Harao Michiko , Kashiwagi Shinichiro , Mase Junichi , Watanabe Junichiro , Nagai Shigenori E. , Yamauchi Chikako , Yamamoto Yutaka , Iwata Hiroji , Saji Shigehira , Toyama Tatsuya
Published: October 2023

The Japanese Breast Cancer Society (JBCS) Clinical Practice Guidelines for systemic treatment of breast cancer were updated to the 2022 edition through a process started in 2018. The updated guidelines consist of 12 background questions (BQs), 33 clinical questions (CQs), and 20 future research questions (FRQs). Multiple outcomes including efficacy and safety were selected in each CQ, and then quantitative and qualitative systematic reviews were conducted to determine the strength of evidence and strength of recommendation, which was finally determined through a voting process among designated committee members. Here, we describe eight selected CQs as important updates from the previous guidelines, including novel practice-changing updates, and recommendations based on evidence that has emerged specifically from Japanese clinical trials.
On vector variational E-inequalities and differentiable vector optimization problem
Authors: Antczak Tadeusz , Abdulaleem Najeeb
Published: October 2023

In this paper, in order to characterize optimality of a class of nonconvex differentiable multiobjective programming problems, we introduce two new types of vector variational-like inequalities, namely, a weak variationalE-inequality and a vector variationalE-inequality. Namely, under (strictly)E-convexity, we prove relationships between the aforesaid vector variational-like inequalities and differentiable vector optimization problems. Further, under (strictly) pseudo-E-convexity, we are in position to identify vector criticalE-points, weakE-Pareto (E-Pareto) solutions of differentiable vector optimization problems and solutions of these introduced vector variational-like inequalities.
Electrochemical Estimation of Cd and Cu Ions Simultaneously Using a Modified MgO/Fe2O3 Nanocomposite/Carbon Paste Electrode
Authors: Abd-Elsabur Keriman M. , Abd-Elsabour Mohamed , Assaf Fawzy H. , Hasan Ibrahem M. A.
Published: October 2023

Heavy metals are serious inorganic pollutants that need to be monitored in the hydrosphere with simple and cheap methods. Herein, a new sensor was fabricated by modifying a carbon paste electrode with MgO/Fe2O3 nanocomposite for simple, rapid, accurate, and highly sensitive simultaneous determination of Cd (II) and Cu (II) using differential pulse anodic stripping voltammetry. The electrochemical behavior of the constructed sensor was examined, and all parameters were optimized including deposition potential, time, pH, and scan rate. For Cd (II) and Cu (II), the respective detection limits were determined to be 3.3 × 10−11 M and 3.6 × 10−11 M, and the respective quantification limits were 1.1 × 10−10 M and 1.2 × 10−10 M. The sensor estimated Cd (II) and Cu (II) in Nile river, tap, and bottled real water samples with high recoveries ranging from 99 to 117%.

Graphical Abstract
Cubosomal functionalized block copolymer platform for dual delivery of linagliptin and empagliflozin: Recent advances in synergistic strategies for maximizing control of high-risk type II diabetes
Authors: Hammad Reham Waheed , Sanad Rania Abdel-Basset , Abdelmalak Nevine Shawky , Latif Randa
Published: October 2023

A well-made chitosan-PVP block copolymer platform was equipped with highly ordered and uniform nano-channels. This highly adhesive block copolymer platform was designed to ensure the efficient co-delivery of two synergistic-acting hypoglycemic drugs. Linagliptin oral bioavailability is 30% due to poor permeability and intestinal degradation. Its pharmacokinetics shows a non-linear profile. Empagliflozin exhibited decreased permeability and decreased solubility in aqueous media between pH 1 and 7.5. Cubosomes were functionalized as a good microdomain to guest and improve the physicochemical characteristics of drug molecules with decreased permeability and solubility. Cubosomes loaded with linagliptin (linagliptin cubosomes (LCs)) and empagliflozin (empagliflozin cubosomes ECs) were separately prepared using the top-down method and optimized by applying 23 factorial design. Optimized cubosomal systems LCs (F3) and ECs (F4) were incorporated into a chitosan-PVP gel to obtain dual cubosome-loaded platforms (LECF) optimized through 22 factorial design. The permeation study from the optimized LECF (C1) ensured enhanced empagliflozin permeation alongside continued efflux for linagliptin, resolving potential risks due to its non-linear plasma profile. The in-vivo study revealed that AUC(0–∞) of linagliptin and empagliflozin was enhanced by 2- and threefold, respectively. Therefore, the chitosan-PVP block copolymer platform buccal application for the co-delivery of linagliptin and empagliflozin could contribute to enhanced clinical effectiveness in treating diabetes.

Graphical Abstract

Graphical abstract showing dual cubosome-loaded platform tested in-vivo using a rabbit model
Two-dimensional forward and backward transition rates
Authors: Bathke Theis , Christiansen Marcus C.
Published: October 2023

Forward transition rates were originally introduced with the aim to evaluate life insurance liabilities market-consistently. While this idea turned out to have its limitations, recent literature repurposes forward transition rates as a tool for avoiding Markov assumptions in the calculation of life insurance reserves. While life insurance reserves are some form of conditional first-order moments, the calculation of conditional second-order moments needs an extension of the forward transition rate concept from one dimension to two dimensions. Two-dimensional forward transition rates are also needed for the calculation of path-dependent life insurance cash-flows as they occur upon contract modifications. Forward transition rates are designed for doing prospective calculations, and by a time-symmetric definition of so-called backward transition rates one can do retrospective calculations.
β cell function and insulin resistance have gender-specific correlations with carotid intima-media thickness in type 2 diabetes
Authors: Lu Weifeng , Wang Kai , Luo Xiumei , Zheng Silan , Zhou Jingqi , Li Shangjian , Chen Ning , Luan Cheng
Published: October 2023

Objective

The relationships between carotid intima-media thickness (C-IMT) and β cell function and insulin resistance in patients with type 2 diabetes (T2D) have not been fully elucidated. This study is to investigate whether impaired glucose metabolism is etiologically associated with C-IMT in patients with T2D.

Methods

The study group consisted of 490 (284 men, 206 women) participants. Venous blood specimens were obtained from all subjects for biochemical profiles after an >8-h overnight fast. C-IMT was measured as the distance between the luminal-intimal leading edge (I-line) and the medial-adventitial leading edge (M-line) on the far wall. Insulin resistance was estimated with the homeostasis model assessment of insulin resistance (HOMA-IR). The acute insulin response to arginine was calculated as the mean of the three plasma insulin levels obtained within 2, 4, and 6 min after the arginine bolus minus the pre-stimulus plasma insulin levels.

Results

There was a graded increase in C-IMT values according to tertiles of HOMA-IR in men; the values of C-IMT were significantly decreased across the tertiles of acute insulin and C-peptide responses in women. Multivariate analysis revealed that HOMA-IR and age were positively associated with C-IMT among men participants, and acute insulin response and current smoking were the independent determinants of C-IMT in women.

Conclusion

Early insulin response stimulated by arginine is independently associated with C-IMT in women T2D individuals, whereas insulin resistance is positively correlated with C-IMT in men T2D subjects.