bluuebunny/crossref_metadata_2025 huggingface dataset:
MAAWf: A Multifunctional and Visual Tool for Microbiomic Data Analyses
Authors: Zhu Sibo , Sun Tao , Zhu Chengkai , Qing Tao , Jiang Yanfeng , Ding Ruifeng , Su Haoxuan , Sun Yunwen , Xu Xiulin , Xu Kelin , Suo Chen , Yuan Ziyu , Zhang Tiejun , Zhao Genming , Ye Weimin , Jin Li , Chen Xingdong
Published: December 2019

Background: Microbiomic research has grown in popularity in recent decades. The widespread use of next-generation sequencing technologies, including 16S rRNA gene-based and metagenomic shotgun-based methods, has produced a wealth of microbiome data. At present, most software and analysis workflows for analysis and processing of microbiomic data are command line-based, which requires considerable computing time and makes interaction difficult. Results: To provide a command-line free, multifunctional, user interface friendly and online/local deployable microbiome analysis tool, we developed Microbiome Automated Analysis Workflows (MAAWf). MAAWf is composed of a whole metagenomic shotgun workflow (WMS) and a 16S Sequencing Workflow. The WMS analysis workflow assesses taxonomy, protein-coding genes, metabolic pathways, carbohydrate-active enzymes (CAZy) and antibiotic resistance genes (ARGs). The 16S ribosomal RNA (rRNA) analysis workflow counts and clusters operational taxonomic units (OTUs), estimates alpha- and beta-diversity and inter-group differences, and performs functional analysis. We also compared MAAWf with other commonly avaiable analysis tools using two public datasets. The MAAWf pipeline was established using the Ubuntu 16.04.6 LTS kernel with primary sequence files such as FASTQ format and taxonomic format such as OTU or BIOM formats. Following analysis of public 16S and WMS datasets, MAAWf obtained similar results to DIAMOND-MEGAN6, MG-RAST, DADA2 and QIIME2, but the running time was much shorter. Conclusions: MAAWf is a visual, integrated, rapid analysis tool that enables remote and local computing of microbiome data.
Prenatal diagnosis of a 16p11.2p11.1 mosaic small supernumerary marker chromosome (sSMC)
Authors: Tidrenczel Zsolt , Tardy Erika P , Pikó Henrietta , Sarkadi Edina , Böjtös Ildikó , Vermes Gábor , Demeter János , Kósa János P , Beke Artúr
Published: December 2019

Background. Small supernumerary marker chromosome (sSMC) is a challenge in prenatal diagnosis. Its’ presence is associated with advanced maternal age and distinct ultrasound findings, prediction of postnatal clinical consequences and prenatal counselling is difficult. Exact characterization of an sSMC is augmented by the application of novel molecular methods such as fluorescent in situ hybridization (FISH) and array comparative genome hybridization (aCGH). Case presentation. Chorion villous sampling of a fetus of a 42-year old secundipara was carried out due to advanced maternal age and the conventional banding cytogenetic examination revealed a mosaic sSMC. Detailed prenatal ultrasound scan showed no fetal malformations. The karyotype from confirmatory amniocentesis was 47,XY,+mar[45]/46,XY. The level of mosaicism was 70% from chorionic villus and amnion cells as well. By using FISH and SNP based aCGH the exact origin of the marker was described and the final prenatal karyotype was determined as 47,XY,+mar[70].arr[GRCh38]16p11.2p11.1(31699804_35989873)x3dn/46,XY[30]. The increase in DNA dosage was 4,29 Mb affecting 20 genes with two OMIM ones (ZNF267 and TP53TG3), the SNP analysis excluded the possibility of uniparental disomy (UPD) of the chromosome. The application of the molecular cytogenetic methods allowed us the differentiate the mosaic marker chromosome from the known 16p11.2 duplication syndrome in close neighboring that is connected to developmental delay and autism spectrum disorder. The present case was identified as a harmless de novo euchromatic variant (EV) of the short arm of chromosome 16. Postnatal karyotyping from neonatal peripheral blood confirmed the presence of the marker. FISH analysis with probe D16Z2 on cultured lymphocyte and buccal smear samples revealed a 64% and 45% mosaic state of the sSMC, respectively. The precise karyotype was finally defined as 47,XY,+min(16)(:16p11.2->p11.1:)dn[64]/46,XY. Conclusions. Novel microarray methods combined with molecular cytogenetic analysis is particularly effective in the rapid and accurate diagnosis of sSMCs, especially in a prenatal situation when the exact characterization of a genomic imbalance is of utmost importance. Precise diagnosis facilitates proper genetic counseling, allows informed decision making and helps avoiding unnecessary pregnancy termination.
Identification and prognosis analysis of germline WT1 (p.Arg370Pro) and TET2 (p.Asp1844Asn) mutations in an acute myeloid leukemia patient with t(9;11)(p21.3;q23.3);KM2TA-MLL3 
Authors: Ma Qiang , Guo Yixian , Lan Xiaoxi , Wang Guoxiang , Liu Congyan , He Jingjuan , Sun Xuejing , Liu Yan , Wan Suigui , Su Li , Sun Wanling
Published: December 2019

Background: Somatic mutations in WT1 and TET2 were separately perceived as contributors to hematopoietic disorders and thought to have a mutually exclusive effect in acute myeloid leukemia (AML). Here, we report a case in which WT1 and TET2 mutations co-existed at different stages in an AML patient with t(9;11)(p21.3;q23.3), and without abnormal WT1 expression, which did not synchronize with the patient's tumor state. Hence, the origins and prognostic value of these two mutations were investigated. Methods: Bone marrow (BM) and buccal mucosal cells were obtained from a 27-year-old male AML patient, and next-generation sequencing (NGS), targeting multiple genes, was performed after DNA extraction. Single nucleotide variant (SNV) and insertion-deletion (Indel) associated with AML were identified in these two samples by using SAM tools. Then, peripheral blood or buccal mucosal cells were obtained from the patient’s relatives, and NGS targeting multiple genes was applied. Besides, the relationship between overall survival (OS) and alteration of these two genes in AML patients was analyzed by using cBioPortal and UALCAN databases, respectively. Results: SNV of WT1 (NM_024426:exon7:c.1109G>C；p.Arg370Pro) and TET2 (NM_001127208:exon11:c.5530G>A；p.Asp1844Asn) were present in the BM of the patient, and these two mutations were also observed in his buccal mucosal cells, which suggested that they were germline mutations. Variation analysis of samples from other relatives indicated that WT1 (NM_024426:exon7:c.1109G>C;p.Arg370Pro) and TET2 (NM_001127208:exon11:c.5530G>A;p.Asp1844Asn) were also present in his father and mother, respectively. The patient’s brother also carried TET2 (NM_001127208:exon11:c.5530G>A；p.Asp1844Asn) mutations. Bioinformatic analysis suggested that mutations in the WT1 and TET2 genes are both associated with a poor prognosis of AML, and abnormal TET2 expression is associated with a poorer prognosis than abnormal WT1 expression. Conclusion: It is firstly report that WT1 p.Arg370Pro and TET2 p.Asp1844Asn mutations co-existed in an AML patient with t(9;11)(p21.3;q23.3) and no WT1 abnormal expression, which highlight the importance of the identification and prognostic evaluation of germline mutations in clinical practice for AML.
Changes in regional cerebral tissue oxygen saturation during anesthesia induction in female patients undergoing breast cancer surgery
Authors: Sheng Fang , Jin Feng , Tan Wen-fei , Ma Hong
Published: December 2019

Background Although the monitoring of regional cerebral oxygen saturation (rScO 2 ) is widely used for cardiac and non-cardiac surgeries, conflicting reports regarding changes in rScO 2 during anesthesia induction remain. We designed this cohort clinical study to assess precise alterations in rScO 2 and the possible mechanism . Methods This cohort study was designed to examine changes in rScO 2 with anesthesia induced by a target control infusion of propofol from the beginning of anesthesia to 30 minutes after induction in patients undergoing breast cancer surgery. rScO 2 values from the right and left sides of patients’ foreheads were averaged to directly determine cerebral oxygenation from FORE-SIGHT data. Mean arterial pressure (MAP), heart rate (HR), partial pressure of oxygen in arterial blood (PaO 2 ), partial pressure of carbon dioxide in arterial blood (PaCO 2 ), hemoglobin concentration (Hb), and cardiac output (CO) were measured every minute until 30 minutes after anesthesia induction. Results A total of 30 female patients treated between January 2016 and April 2016 were included in this study. The average rScO 2 at 7 minutes was 81.7%, which was higher than the average rScO 2 at baseline (67.3%) and at 15 minutes (68.3%). Average rScO 2 correlated significantly with PaO 2 during the first 7 minutes of anesthesia induction. Conclusion During anesthesia induction, changes in rScO 2 , which increased to a peak value at 7 minutes, may be correlated with increases in PaO 2 , and the return of rScO 2 to baseline at 15 minutes may have occurred due to flow-metabolism coupling and balancing between white matter and gray matter.
Assessment of factors affecting voluntary counseling and testing service utilization among preparatory school students in Gondar town, Amhara region, Ethiopia
Authors: Demeke Getaneh Bizuayehu , Alazbih Nega Mihret
Published: December 2019

Background Globally the adolescent and youths are facing different sexual and reproductive health problems like unwanted pregnancy, unsafe abortion, STI including HIV.HIV / AIDS is continue to be a major global health priority. HIV counseling and testing is a key strategic entry point to prevention, treatment, care and support services .HIV/AIDS counseling is “confidential communication between client and a care provider aimed at enabling the client to cope with stress and to take personal decisions relating to HIV/AIDS.VCT give clients an opportunity to explore their HIV risks and to learn their HIV test results in complete confidence.Objective The objective of the study was to asses factors affecting voluntary counseling and testing service utilization among preparatory school students in Gondar town.Methods Institutional based cross-sectional study design was employed. A multistage sampling procedure was conducted in the study area. Data were collected using pretested self-administered questionnaire and the data entered, clean and analyzed by using SPSS version 16 software. Descriptive, bivariate and multivariate analysis were employed. Multivariate analysis with 95% CI was computed to identify factors associated with voluntary counseling and testing service utilization at P-value <0.05.Results A total of 654 study participants were included in the study with the response rate of 97%. The study indicated that 81.7% of study participants knew about voluntary counseling and testing services utilization .But the practice of voluntary counseling and testing was 48.3% with (95% CI: 44.5 -52.1).Based on the finding of multivariate analysis among independent variables, age, place of birth, mother’s educational level and discussed with parents on the issue of VCT were significantly associated with voluntary counseling and testing services utilization.Conclusion Majority of the study participants were not utilize voluntary counseling and testing services, only few respondents ever had VCT test as well as the proportion of students who had discussed on VCT issues with their parent was also very low. Cultural taboos was the main obstacle to students did not discuss with parents on the issue of VCT in the study area. Therefore; it needs great effort all concerned body to improve their services utilization. In broadly family life education should be encourage for the students and parents to promote VCT utilization.
CpG single nucleotide polymorphisms of the insulin signaling pathway associated with the risk of prediabetic status/type 2 diabetes in Chinese population
Authors: Tang Linlin , Wang Changyi , Han Liyuan , Ma Jianping , Cheng Jia , Duan Shiwei
Published: December 2019

Aims: Cytosine-phosphate-guanine single nucleotide polymorphisms (CpG SNPs) have been identified as new markers in human diseases. We aimed to evaluate the contribution of 29 CpG SNPs in the insulin signaling pathways to the risk of prediabetes and type 2 diabetes (T2D) in Han Chinese. Materials and methods: We recruited 708 T2D subjects, 253 prediabetes subjects and 575 healthy controls from 16 community health service centers (CHSC) in Shenzhen Nanshan district. Detailed clinical information and DNA samples were collected. A total of 29 CpG SNPs of the insulin signaling pathways were sequenced using the MassARRAY platform. Binary logistic regression was applied to evaluate the association between these 29 CpG SNPs with prediabetes and T2D after adjusted the relevant confounding factors. The potential interactions among the 29 CpG SNPs were conducted by the generalized multifactor dimensionality reduction (GMDR). Results: Significant associations are found between KRAS rs7311692 [Padjusted = 0.009, OR = 0.562(0.363-0.868) by allele] and CBLC rs2965143 [Padjusted = 0.008, OR = 1.591(1.128-2.242) under the dominant model] with prediabetes. A further breakdown analysis by gender identify a significant association between MAPK9 rs1363513 and T2D risk in males [Padjusted = 0.004, OR = 0.57(0.399-0.836) by allele], while FLOT2 rs4795473 is associated with prediabetes in females (P = 0.007 by genotype). However, no significant effect of potential interaction is observed among the 29 CpG SNPs. Conclusion: These results indicated that KRAS rs7311692, CBLC rs2965143 and FLOT2 rs4795473 are related with prediabetes, while MAPK9 rs1363513 was associated with male T2D.
MicroRNAs as potential biomarkers for the diagnosis of traumatic brain injury: a systematic review and meta-analysis
Authors: Zhou Qian , Yin Jian , Wang Yadong , Zhuang Xinsuo , He Zhiyang , Chen Zuobing , Yang Xiaofeng
Published: December 2019

Background: Traumatic brain injury (TBI) is a sudden trauma on the head, commonly associated with death and long-term disability. MicroRNAs (miRNAs) are potential biomarkers of diverse diseases, including TBI. However, few systematic reviews and meta-analyses have been conducted to determine the clinical value of miRNAs expression in TBI patients.Methods: We did a comprehensive literature search to identify articles that have reported on the diagnostic and prognostic value of miRNAs expression in TBI patients.Results: Six studies investating the diagnostic value of miRNA in TBI were analyzed in this study. The overall sensitivity, specificity and area under the curve (AUC) of miRNAs in diagnosis of TBI were 92% [95% confidence interval (CI): 0.87–0.95]; 92% (95% CI 0.78–0.97) and 96% (95% CI 0.94–0.97), respectively. We found that panels of multiple miRNAs could improve the diagnostic accuracy of TBI. Compared to saliva, detected samples like blood and brain tissue could significantly enhance diagnostic accuracy. Besides, the AUC of miRNAs in severe TBI was 0.97, with 92% sensitivity and 92% specificity.Conclusions: This systematic review and meta-analysis demonstrated that miRNAs could be potential diagnostic markers in TBI patients. MiRNAs detected in blood and brain tissue display high accuracy for TBI diagnosis.
Epidemiology of Epizootic Lymphangitis of cart horses in Northern Ethiopia Using Conventional diagnostic Methods and Nested Polymerase Chain Reaction
Authors: Abera Birhanu Hadush , Michaelay Molla , Taddele Habtamu , Abebe Nigus , Tesfay Abrha , Bitsue Habtom Kiros , Afera Berihun , Duguma Bojia E. , Gugsa Getachew , Ameni Gobena
Published: December 2019

Background: Epizootic lymphangitis (EL), caused by Histoplasma capsulatum variety farciminosum (HCF) is a contagious chronic disease of equines characterized by development of nodular lesions in the lymph nodes, lymphatic vessels and skin. This disease is the most important diseases of equines in Ethiopia causing a significant economic loss, particularly cart pulling equines. Todate there is no sound diagnostic nor control measure implemented in the country. Furthermore, there is a shortage of data on the epidemiology of the disease in different regions of the country including northern Ethiopia. This study was conducted to investigate the epidemiology of EL in northern Ethiopia using the conventional methods and the nested polymerase chain reaction (PCR). Methods: A total of 191 cart-horses were enrolled and used as sources of pus and blood samples. The blood was used for the extraction of the DNA of HCF from buffy coat for nested PCR while the pus samples were cultured on Sabourauds Dextrose Agar for isolation. Statistical Package for Social Sciences (SPSS) version 21 was used for data analysis by applying logistic regression, receiver operating characteristic (ROC) curve and Cohen’s kappa coefficient test. In addition, the level of agreement between the clinical examination and the nested PCR was evaluated. Results: Infection with HCF was confirmed in 44% (84/191) of the horses using nested PCR. Subclinical infection was observed in 18.18% (22/121) of the apparently healthy horses. Considering nested PCR as a gold standard, the sensitivity and specificity of the clinical examination were 74% and 95%, respectively while the area under the ROC curve (AUR) was 0.83 (95% confidence interval, 0.77, 0.896). Moreover, a moderate (k=0.675) agreement was observed between the nested PCR and clinical examination.Conclusions: The findings of the present study showed the wide spread occurrence of EL in northern Ethiopia and the advantage of the nested PCR in detecting of the infection of HCF even before the clinical symptoms are apparent.
Differential Network Analysis Reveals Regulatory Patterns in Neural Stem Cell Fate Decision
Authors: Xie Jiang , yang Fuzhang , Sun Jiamin , Wang Jiao
Published: December 2019

Background Neural stem cell (NSC) differentiation is one of many multi-stage lineage systems that require multiple cell fate decisions. Recent single-cell transcriptome datasets became available at individual differentiation, however, a systematic and integrative analysis of multiple datasets at multiple temporal points of NSC differentiation is lacking. Results Here we investigate five NSC differentiation paths by analyzing and comparing four different single-cell transcriptome datasets. By constructing gene regulatory networks for each cell type, we delineate their regulatory patterns via analyses of differential topology and network diffusion. Among the five NSC differentiation paths, we find 12 common differentially expressed genes, with one common three-gene regulatory pattern shared by all paths. The identified regulatory pattern, partly supported by previous experimental evidence, is found to be essential to all differentiation paths, however, plays a different role in each path when regulating other genes. Conclusions Together, our integrative analysis provides both common and specific regulatory mechanisms for each of the five NSC differentiation paths, and the approach can be applied to analyzing other complex multi-stage lineage systems.
Research on Education Effect for Chinese Medical Students' Learning Style Based on Kirkpatrick Model and Structural Equation Model
Authors: Lu Juan , Shi Yang , Hu Xiuhua , Qiu Xueping , He Qian , Liu Jun
Published: December 2019

Background: The recognition of learning style was not optimistic in China. The evaluating indices of education effect were vague and adopted some ready-made indices such as teaching satisfaction or academic achievement. Those indices have their own basis and significance, but one mere index can not reflect education effect comprehensively.Methods: We used Kirkpatrick model to appraise Chinese medical education effect by selecting appropriate indices for the four levels and structural equation model (SEM) to explore the correlation among those indices after a survey on 17460 medical students.Results: 1) Kirkpatrick model: Level 1 students’ satisfaction scored 4.19±0.993; Level 2 learning motivation 1.95±0.568; Level 3 the Visual 0.227±0.131, Aural 0.300±0.138, Read/Write 0.273±0.138 and Kinesthetic 0.324±0.144 for sensory learning style, Extroversion 0.531±0.207, Sensing 0.597±0.186, Thinking 0.585±0.207, Judging 0.662±0.225 for personality type and Concrete Experience 32.03±6.394, Reflective Observation 33.41±6.486, Abstract Conceptualization 34.13±6.650, Active Experimentation 34.00±6.600 for empirical learning style; Level 4 learning attitude 2.68±0.781, learning expectation 2.14±0.953 and academic achievement 2.43±0.793. 2) SEM: the fitting indices were 0.687-0.581. Most of the paths were valid except for VARK, T and J parts (t < 2, P > 0.05).Conclusions: Kirkpatrick model with selected indices evaluated comprehensively the education effect (learning style was one important index); there were actually relations among those indices; based on the importance tested by SEM and students’ satisfaction obtained from the survey, we sorted the college cultivating works into four types, among which type B (important but unsatisfactory work) urge most to be strengthened.
Cloning and characterization of an exocellulase and synergistic effect with recombinant endocellulase and beta-glucosidase from Bacillus subtilis 1AJ3
Authors: Ma Lingling , Chen Jiaxin , Wang Xin , Yi Yanglei , Shan Yuanyuan , Liu Bianfang , Zhou Yuan , Lü Xin
Published: December 2019

Background: Biomass lignocellulose provide abandon cellulosic material for bioenergy. The synergy effect of the cellulase system still needs more attention to make it more efficient. Exocellulase was less of studies in former studies, especially recombinant exocellulase from bacteria. Results: An exocellulase Cbh -A from strain B. subtilis 1AJ3 was cloned and expressed in E.coli BL21. By sequence analysis, Cbh -A contains two domains: FlgJ and SH3_8. Enzymatic properties of Cbh -A were characterized, and the maximum enzyme activity was gotten under the condition of pH 6.4 and 50℃. Moreover, the enzyme reached the highest enzyme activity and kept stable under 50℃ for 4 h. Ion metal Mn 2+ had an activating effect on Cbh -A, while Cu 2+ as well as chemical EDTA had inhibition effect. Cbh -A had widely substrates specification that it could hydrolyze β-1,3-1,4/β-1,3/β-1,4 glucan linkage, α-1,4 glucan linkage . When it took cooperation with recombinant endocellulase and β-glucosidase also from the strain B. subtilis 1AJ3, synergism effect was observed through DS (degree of synergism) value by hydrolyzing CMC-Na, Avicel, and filter paper. At the same time, the synergism effect was also examined in biomass lignocellulose by comparing the saccharification rate and DS value of each material. Conclusions: Cbh -A contained a FlgJ domain and first studied as an exocellulase cloned from B. subtilis 1AJ3. The biochemical, enzymatic properties, ion metal, and substrate specificity of Cbh -A were analyzed, and a special character of Cbh -A could keep maximum activity after pre-warm at 50℃ for 4h. Cbh-A had good synergy effect with endocellulase and β-glucosidase from the same strain in variety kind of cellulosic substrates, including simple and complex biomass cellulose. It laid a foundation of application by mixed cellulases via synergy effect, and supply new thought for the degradation of biomass lignocellulose.
Correlates of mistime pregnancy and unmet need for family planning among women of reproductive age in Sandema, Ghana.
Authors: Dun-Dery Elvis Junior , Yendaw Elijah , Dun-Dery Frederick , Bagrmwin Lawrence
Published: December 2019

Background: Universally, an estimated 80 million unintended pregnancies comprising both mistimed and unwanted pregnancies are recorded yearly, but only half of women at risk of a mistimed pregnancy use contraceptives. In developing countries, over 100 million females have unmet need and national surveys in Ghana indicate a 29% unmet need rate. Methods: A cross-sectional community based study was used, involving the use of multi-step cluster sampling methods in selecting 300 women of reproductive age. The study was quantitative in nature, using structured interviewer administered questionnaires. Results: More than half (66%) of the women in reproductive age still had unmet need, 71% were currently pregnant and 36% confirmed ever having a mistimed pregnancy. Overall, 53% of the women confirmed never communicating on family planning issues with their partners, a little below half (45%) of the respondents took their own health care decisions and 79% ever received family planning services from a health professional. Factors related to unmet need included mistimed pregnancy, level of education, preferred birth/pregnancy interval, communication between partners and the autonomy to spend self-earnings. Conclusion: Considering that high rates of unmet need results in mistimed pregnancy, improved policies around the influence of unmet need on mistimed pregnancies are needed.
Didelį kategorijų kiekį turinčių draudimo bendrovės klientų užklausų, gautų elektroniniais laiškais, lietuviško teksto klasifikavimas
Authors: Kiaune Karolis , Ramanauskaitė Simona
Published: December 2019

Natūralios kalbos apdorojimas ir klasifikavimas jau plačiai naudojamas anglakalbėse šalyse. Tačiau lietuviško teksto analizė ir klasifikacija yra sudėtinga ir dar nevisiškai įgyvendinta. Taip yra dėl lietuvių kalbos sudėtingumo ir savitumo, todėl kitoms kalboms tinkami metodai ne visada tinka lietuvių kalbai.Šiame straipsnyje naudojamos trys pasirinktos tekstų apdorojimo parinktys bei įvairios jų kombinacijos ir įvertinama, kaip skirtingi nuoseklūs teksto klasifikavimo būdai gali klasifikuoti draudimo bendrovės klientų užklausas, gautas el. paštu. Šis tyrimas yra išskirtinis naudojamų metodų gausa ir papildomai įvertina lietuviško teksto klasifikavimo tikslumą daugelyje (33) kategorijų.Straipsnyje aptariamos natūralios kalbos apdorojimo problemos, analogiški tyrimai su lietuvių kalba parašytų tekstų klasifikacija, pristatoma siūloma tyrimo metodika ir aptariami tyrimo rezultatai.
European SMEs’ value management based on controlling, financial analysis and ratios – empirical study
Authors: Písař Přemysl
Published: December 2019

Small and medium enterprises (SMEs) are a powerful economic force, significant employers, and creators of added value. In the European Union SMEs are the backbone of its economic and innovative potential, and for this reason, economic development and stability of SMEs are critical. The goal of this study is to apply modern controlling to the management of SME value growth using the tools and indicators of financial analysis. This study is based on a detailed analysis of 359 companies from the European Union in order to test 4 hypotheses. The data obtained were subjected to statistical analysis to identify the dependence between the controlling management of a company, tools of financial analysis, innovative potential, level of digitization, internal auditing, and HR communication tools used in the SME. The statistical analysis confirmed a close relationship between the studied variables and created a model for managing the company’s value growth for the study sample of SMEs. Subsequent experimental testing was used to confirm these conclusions, and other important associations were found that are important for successful management of SMEs value growth. The findings obtained are applicable in practice and can be used for a deeper analysis of the issues in question.
DISCRICIONARIEDADE ADMINISTRATIVA E RESPONSABILIDADE DECISÓRIA: UMA LEITURA CONTEMPORÂNEA
Authors: Balera José Eduardo Ribeiro
Published: December 2019

O surgimento e o fortalecimento do Estado de Direito impuseram, a partir do substrato normativo constitucional, balizas ao agir dos indivíduos em sociedade, ao próprio aparato estatal e aos seus administradores. Assim, a Administração Pública, dotada de prerrogativas, é incumbida do atingimento de resultados coletivamente relevantes e desejados. Neste cenário, o presente trabalho tem por objetivo analisar o espaço da discricionariedade administrativa em face às exigências de correção decisória, em especial, pelo rigorismo imposto pela teoria hermenêutica jurídica contemporânea. Inicialmente, apresenta-se o entendimento consolidado na dogmática jurídica acerca da discricionariedade e seus aspectos de divergência. Em seguida, expõe-se a relação entre a atividade interpretativa e o agir discricionário, segundo a doutrina administrativista. Em continuidade ao estudo sistemático deste instituto jurídico, examina-se as diferentes espécies de discricionariedade e suas potenciais fragilidades. Por fim, são pormenorizadas as críticas advindas da hermenêutica contemporânea em razão do direito fundamental à resposta correta ou “verdadeira”.
O VOTO NO DIREITO BRASILEIRO: HISTÓRIA, PROBLEMAS E PROPOSTAS DE MUDANÇA
Authors: De Laurentiis Lucas Catib , Azevedo Bianchi Yohanan David
Published: December 2019

O presente trabalho discute sobre o sistema eleitoral brasileiro no Estado Democrático de Direito e o voto obrigatório dentro deste sistema, levantando hipóteses a serem respondidas no decorrer da pesquisa. O método de pesquisa utilizado é o qualitativo, para sintetizar as informaçõese conclusões do referido trabalho. A princípio, faz necessário um estudo histórico dos sistemas eleitorais e do voto bem como suas origens, fundamentos, finalidades, limites e conceito atual. Outra questão que será abordada é o direito comparado entre outros sistemas eleitorais existentes. Sendo que ao final, o trabalho será concluído na busca de respostas dos questionamentos levantados, através das considerações finais.
DIREITO CIVIL CONSTITUCIONAL E A FUNÇÃO SOCIAL DA POSSE: REFLEXÕES SOBRE O ACÓRDÃO ARE N. 1047694–RJ DO SUPREMO TRIBUNAL FEDERAL
Authors: Vieira Marcelo De Mello , Matos Sillmann Marina Carneiro
Published: December 2019

Neste artigo é proposta uma análise da posse sob o prisma do direito civil constitucional, destacando os aspectos da função social. A fim de avaliar como o conceito de função social da posse se apresenta nos tribunais brasileiros, utilizou-se como base, o acórdão ARE n. 1047694 do Supremo Tribunal Federal. Foi feita uma pesquisa teórica-documental, analisando obras escritas sobre a temática proposta e alguns julgados do Supremo Tribunal Federal e do Superior Tribunal de Justiça. Concluiu-se que a função social da posse é um conceito dinâmico e que para verificar seu cumprimento deve-se analisar o caso concreto.
Francisco Rodríguez Valls. (2017). Orígenes del hombre. La singularidad del ser humano. Madrid: Biblioteca Nueva, S. L.
Authors: Toso Andreu Pablo Ilian
Published: December 2019

La siguiente es una reseña del estudio realizado por el profesor Francisco Rodríguez Valls de la Universidad de Sevilla respecto a la incertidumbre que supone la naturaleza y la condiciónn de la realidad humana. El análisis se avoca a una visión paranorámica del trabajo del profesor Valls, y de manera introductoria apunta los aspecto claves de su texto a fin de que el lector pueda hacerse una idea clara y concisa de la propia postura del autor.
Javier Espino Martín, Giuditta Cavalletti (eds.) (2017). Recepción y modernidad en el siglo XVIII. La antigüedad clásica en la configuración del pensamiento ilustrado. México: Centro de Estudios Clásicos, Instituto de Investigaciones Filológicas, UNAM
Authors: Charpenel Eduardo
Published: December 2019

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Formulasi Model Perkuliahan Daring Sebagai Upaya Menekan Disparitas Kualitas Perguruan Tinggi
Authors: Mustofa Mokhamad Iklil , Chodzirin Muhammad , Sayekti Lina , Fauzan Roman
Published: December 2019

A one-step using network technology and information technology for the development of learning system in universities is online lecturing system. This learning system is assessed as highly efficient, because the same learning resources can be used by hundred people at the same time. So, college student that lives in isolated area can access the subjects of reputable universities in Indonesia. Hence, the quality disparity of universities will be decreased.

This study is qualitative descriptive research. The object of this study is on website pditt.belajar.kemdikbud.go.id. This website is developed by the Ministry of Education and Culture Indonesia. The selection of that locus is because the website is an official website of government which collaborate with some reputable universities in Indonesia, such as University of Indonesia, Bandung Institute of Technology, Gajahmada University, Sepuluh November Institut of Technology, Aptikom, and Bina Nusantara University.

The result showed that online lecturing system has positive contribution for  pushing the quality disparity of universities in Indonesia. The indications such as 1) Minimize the limitation of access to higher education that have a certain quality. 2) Cut-off the limitation of facilities that had been cosidered as one of obstacles of the lower quality of higher education. 3) Eliminate the limitation of understanding to certain material. 4) Online lecturing system gives wide access to educational resources, especially in reputable universities.
Perancangan Geographic Information System Berbasis Android Untuk Potensi Mebel Di Kecamatan Tahunan Kabupaten Jepara
Authors: Tamrin Teguh , Zyen Akhmad Khanif , Dina Maula Hashina
Published: December 2019

Jepara is a city called carving city because it has a large furniture and carving industry

potential. Tahunan Subdistrict is an area located in Jepara regency with the biggest potential of the furniture industry compared to other districts. Everyone who wants to buy furniture from Tahunan may visit the showroom which is located not far from the main road because of the limited information about the potential of furniture, especially small and medium business category in less strategic locations. Judging from these problems, it is necessary to make an information system about the potential of furniture in Tahunan district based on android that is easy to use and integrated with Geographic Information System (GIS) to make it  easier for users to find directions to the location. The system development method used is Rapid Application Development (RAD) with Construct 2 as the maker of the application.
Sistem Informasi Penjualan Obat Pertanian Berbasis Web pada Toko BUTANI Blora
Authors: Damayanti Erni
Published: December 2019

Sistem Informasi ini membahas mengenai penjualan barang, penelitian ini dilakukan pada toko BUTANI Blora adalah sebuah wirausaha yang bergerak dibidang penjualan obat pertanian antar lain obat-obatan pertanian, pupuk pertanian, peralatan pertanian. Masalah yang sering dihadapi toko BUTANI Blora adalah pencatatan transaksi penjualan yang masih manual, sulitnya dalam perhitungan nilai akhir penjualan barang, pencatatan transaksi penjualan yang memerlukan ketelitian dan ketepatan dalam menghitung , dikarenakan antara lain pencatatan dan perhitungan jumlah suatu barang saat ini masih menggunakan sistem yang belum tertata, sehingga sering terjadi kelebihan atau kekurangan stok, hal tersebut akan berdampak pada pelayanan kebutuhan konsumen yang kurang laku.

 

Sistem informasi penjualan obat pertanian berbasis web juga sangat dibutuhkan dalam perusahaan untuk mencatat transaksi penjualan dan untuk membuat laporan penjualan. Untuk membangun sistem informasi tersebut menggunakan bahasa pemrograman PHP dengan database MySQL, aplikasi ini dibuat untuk mempermudah mencatat transaksi penjualan dan membat laporan penjualan.

 

Dengan adanya sistem informasi penjualan diharapkan perusahaan dapat membantu manajemen dalam melakukan pencatatan transaksi penjualan, dapat mengetahui stok barang, dan laporan-laporan yang dibutuhkan.
Evaluasi Faktor-Faktor Yang Mempengaruhi Performa Implementasi SAP ERP Di Industri Retail
Authors: Bakhri Syaiful
Published: December 2019

This study aims to examine the factors that affect the performance of the ERP implementation. These factors are: the data migration, system documentation, knowledge transfer, system testing, and integration interfaces. These factors can increase the performance of the implementation of ERP software applications that are on retail industry. The case study method in this research is using interviews and direct observation, the object of the interview in this study is Functional modules of SAP ERP. Sources of data derived from primary data and secondary data. The results of this study indicate that factors influence on the performance of retail industry. Therefore, the factors to be considered in order to improve the success of SAP ERP project in the future. The theoretical implications and suggestions for future research are also discussed in the final part of this study. (SB)
Outstanding Contemporaries on the Formation of School Education in Russia of the Second Half of the XIX Century
Authors: Emelyanova Natalia
Published: December 2019

The research featured some trends in the formation of the Russian school during the second half of the XIX century in the interpretation of the contemporary representatives of pedagogy, science, and journalism. The paper also focuses on their participation in the formation of the educational system and female education. The author identified directions in the formation of school during that period, as well as revealed the attitude of academia and improvements they suggested. The methodological basis was provided by previously unstudied material. Its theoretical and comparative analysis made it possible to reveal the opinions of celebrated authors of that time about the organization of the educational process in male and female grammar schools that belonged to various departments. Grammar schools for girls seemed to play a special role in Russia as they were connected with teacher training and contributed to the formation of elementary schools. The opinions of the famous contemporaries made it possible to draw certain conclusions regarding the organization of the educational process, the specifics of the educational situation, and the problems that had to be addressed in order to develop the Russian system of education. The results can be used in the syllabus of History of Pedagogy and Education, various elective courses, and research work of students.
Academic Mobility at Siberian Federal University
Authors: Shelkunova Tatyana , Artyukhova T.
Published: December 2019

The article provides a theoretical analysis of the concept of "academic mobility" and focuses on the components of academic mobility of students at Siberian Federal University. The authors analyzed the documents that regulate academic exchange at Siberian Federal University. The paper summarizes pedagogical studies of problems experienced by Russian and foreign students, both participating and not participating in academic mobility programs. The paper introduces a questionnaire for the ascertaining experiment and its analysis. The theoretical and experimental analysis revealed the main difficulties faced by Russian and foreign Erasmus students. It also checked their awareness of various academic mobility programs and opportunities. Based on the results obtained, the authors developed recommendations that will help program managers to improve the implementation of academic exchange programs and their promotion.
Bioavailability Study of Recombinant Plasmid DNA Nerve Growth Factor after Intramuscular Injection by Electroporation
Authors: Shilov Viktor V. , Yudin Mikhail A. , Vengerovich Nikolai G. , Shcherbakov Taras V. , Bogacheva Aleksandra S.
Published: December 2019

Comparative analysis of plasmid DNA delivery into cells efficiency (with effective agent concentration 250 μg/kg), ensuring accumulation of nerve growth factor (NGF) after intramuscular injection and intramuscular administration using electroporation method on rats was performed. Application of electroporation method ensured over 4 times increase of DNA plasmid concentration in muscle tissue within the first hour after its injection and increased the duration of its determination. Higher bioavailability parameters were confirmed by 3 times increase in gene expression level, encoding NGF accumulation and 3 times increase in concentration of the target NGF protein in blood plasma. The results obtained allow us to recommend this method for introduction of NGF plDNA in its biological activity and effectiveness in models of nerve damage investigation.
Problems of diagnostics and treatment of diffuse — toxic goiter (Graves’ disease)
Authors: Ismailov Saydiganikxodja I. , Khayitboyeva Komila Kh.
Published: December 2019

The article is devoted to prevalence, contemporary diagnostic methods and treatment of Grave’s disease. Advantages and disadvantages of different treatment options are discussed. The cause of the disease can be environmental conditions, infectious diseases, severe operational intervention, drugs, trauma, especially brain traumas, iodine deficiency and radiation damage of thyroid in iodine deficiency conditions, familial predisposition. The ideal treatment of Graves’ disease should ensure a fairly rapid elimination of clinical symptoms of thyrotoxicosis, return to an euthyroid state, with minimal risk of complications. The relapse rate of the disease can reach up to 80 %, using conservative treatment. The radioiodine ablation is relatively simple, non-invasive, effective and cheap. There are special indications for surgical treatment. Indications for surgical treatment: 1) large goiter (the volume of the thyroid gland is more than 45 ml); 2) frequent recurrences of thyrotoxicosis and failure of the drug and RIT; 3)malignancy of goiter; 4) allergic and toxic (leukopenic) reactions to thyreostatics. Patients with Graves’ disease should referred to a specialized center with multidisciplinary team.
Arrangement of social aid for children with orthopedic pathology considering their psychological constitution
Authors: Kopytenkova Olga I. , Pyatakova Galina V. , Umnov Valery V.
Published: December 2019

Modern society development is accompanied by increase of number of physically challenged individuals, including children. In Russia, about 15 million people are disabled. The social sphere is developing and improving, the priority direction of which is the creation of an optimal system of life support for children with disabilities. One of the most numerous handicapped children groups is a group with orthopedic pathology. Today information concerning number of handicapped children is coming from three different sources which are not harmonized internally. The work presents comparative analysis of statistical data form, containing information on handicapped children prevalence in relation to orthopedic pathology; dependence of handicapped children prevalence in relation to orthopedic pathology on the number of children with pathology, revealed for the first time. All the data concerning psychological particularities of handicapped children with orthopedic pathology was systematized. Directions of social aid improvement were justified.
On-line optimization of biomethane production in continuous AD processes via model-based ESC approach
Authors: Lara-Cisneros G. , Dochain D. , Álvarez-Ramírez J.
Published: December 2019

This paper is aimed at designing a class of model based extremum-seeking feedback controllers (ESC) for the on-line optimization of biomethane production rate in continuous anaerobic digestion (AD) processes. The ESC scheme is based on the modelling error compensation approach coupled with a first-order gradient estimator. The feedback control law is able to keep the concentration of volatile fatty acids (VFAs) near the unknown optimal setpoint while the methane production rate is maximized. Unlike other ESC algorithms applied to AD processes, the proposed control scheme includes a continuous uncertain estimator and avoids excessive oscillations in the control action. Numerical simulations compare the performance of the proposed ESC controller with traditional perturbation-based and sliding mode based approaches.
Study on mitigating membrane fouling based on precursor and flocculant Alb matching in EC/O-UF system
Authors: Su Fei , Li Ying-Hua , Deng Wen-He , Li Hai-Bo , Yang Lei , Chen Tian-yu
Published: December 2019

One of the effective ways to remove halogenated disinfection by-products (DBPs) from drinking water is the application of ultrafiltration technology. However, membrane fouling is an important factor affecting the service life and treatment effect. In this study, the electrocoagulation/oxidation-ultrafiltration (EC/O-UF) process was used to remove the precursor substance that produced DBPs, i.e. dissolved organic matters (DOMs). Operating parameters were optimized from the matching of different flocculant morphology to low concentration DOM. The degree of membrane fouling was characterized by analyzing DOMs concentration and membrane flux. The results showed that the optimal conditions for the production of Alb were: current density 10 A/m2, hydraulic retention time 10 min, and initial pH 5.0–7.0. Under these conditions, the production of flocculant Alb could reach 58–61%, 94–97% DOMs were removed by EC/O-UF.
Editorial
Authors: COSTA Erli Schneider , Semensatto Simone
Published: December 2019

Estamos encerrando o ano de 2019 com a certeza de que a Revista Eletrônica Científica da UERGS está ganhando a confiança de autores e de leitores de áreas do conhecimento interdisciplinar e da comunidade em geral. Neste ano, a Diretoria de Avaliação da Coordenação de Aperfeiçoamento de Nível Superior – CAPES – divulgou uma recente classificação de periódicos que utiliza uma nova forma de avaliação levando em consideração a qualidade do periódico. Conforme esse atual processo de avaliação, a RevUergs passou a ser classificada no estrato Qualis B1, o que indica um avanço em relação à classificação anterior, B4.
Efeito de Azospirillum brasilense e ácido indolbutírico no enraizamento de miniestacas de Tibouchina fothergillae
Authors: DUARTE Manoela Mendes , MARTIN Daniela Maria , MORAES Renata Franciéli , ZUFFELLATO-RIBAS Katia Christina
Published: December 2019

O presente estudo objetivou avaliar a influência de bactérias promotoras do crescimento (Azospirillum brasilense) e do ácido indolbutírico (IBA) na rizogênese de miniestacas de Tibouchina fothergillae (D.C.) Cogn. Para tanto, miniestacas caulinares foram coletadas de minijardim clonal, preparadas com 6 ± 0,2 cm de comprimento e mantendo-se um par de folhas reduzidas à metade. Após a desinfestação, as bases das miniestacas foram tratadas com ácido indolbutírico (0, 1000 e 1500 mg L-1) e com solução inoculante de Azospirillum brasilense (puro e diluído 1:1), sendo os propágulos plantados em tubetes com vermiculita e mantido em casa de vegetação. Após 60 dias foram avaliadas a porcentagem de enraizamento, número de raízes por estaca, comprimento médio das 3 maiores raízes por estaca, miniestacas vivas e mortas, emissão de brotação, manutenção de folhas. e massa seca de parte aérea e raiz. Os resultados para todas as variáveis não apresentaram diferença estatística ao nível de 5% de probabilidade pelo teste de Tukey. Os resultados indicam que T. fothergillae é de fácil enraizamento, e que os tratamentos com IBA e Azospirillum brasiliense não influenciam na rizogênese da espécie.
Instruções sobre as escolas de primeiras letras expedidas pelo Príncipe Regente e o Conde de Linhares (Portugal, 1798-1800)
Authors: Alves Dias Thiago
Published: December 2019

Instruções sobre as escolas de primeiras letras expedidas pelo Príncipe Regente e o Conde de Linhares (Portugal, 1798-1800)