bluuebunny/crossref_metadata_2025 huggingface dataset:
Probabilistic Modeling of Maritime Accident Scenarios Leveraging Bayesian Network Techniques
Authors: Liao Shiguan , Weng Jinxian , Zhang Zhaomin , Li Zhuang , Li Fang
Published: July 2023

This paper introduces a scenario evolution model for maritime accidents, wherein Bayesian networks (BNs) were employed to predict the most probable causes of distinct types of maritime incidents. The BN nodes encompass factors such as accident type, life loss contingency, accident severity, quarter and time period of the accident, and type and gross tonnage of the involved ships. An analysis of 5660 global maritime accidents spanning the years 2005 to 2020 was conducted. Using Netica software, a tree augmented network (TAN) model was constructed, thus accounting for interdependencies among risk-influencing factors. To confirm these results, a validation process involving sensitivity analysis and historical accident records was performed. Following this, both forward causal inference and reverse diagnostic inference were carried out on each node variable to scrutinize the accident development trend and evolution process under preset conditions. The findings suggest that the model was competent in effectively predicting the likelihood of various accident scenarios under specific conditions, as well as extrapolating accident consequences. Forward causal reasoning unveiled that general cargo ships with a gross tonnage of 1–18,500 t were most prone to experiencing collision and stranding/grounding accidents in the first quarter. Reverse diagnostic reasoning indicated that, in the early morning hours, container ships, general cargo ships, and chemical ships with a tonnage of 1–18,500 t were less likely to involve life loss in the event of collision accidents.
Distributed Event-Triggered Fixed-Time Leader–Follower Formation Tracking Control of Multiple Underwater Vehicles Based on an Adaptive Fixed-Time Observer
Authors: An Shun , Liu Yang , Wang Xiaoyuan , Fan Zhimin , Zhang Qiang , He Yan , Wang Longjin
Published: July 2023

This paper focuses on the fixed-time leader–follower formation control of multiple underwater vehicles (MUVs) in the presence of external disturbances. First, an adaptive fixed-time disturbance observer (AFxDO) is developed to deal with unknown time-varying environmental disturbances. The developed AFxDO guarantees the fixed-time convergence property of the disturbance observation error and no prior information on the external disturbances or their derivatives is required. Then, with the aid of the developed AFxDO, a distributed event-triggered fixed-time backstepping controller was developed to achieve the leader–follower formation tracking control of MUVs. To solve the “explosion of complexity” problem inherent in the conventional backstepping, a nonlinear filter is introduced to obtain the derivative of the virtual control law. Furthermore, to reduce the communication burden, the event-triggered mechanism is integrated into the formation tracking controller. The stability analysis shows that the closed-loop MUV system is practical fixed-time stable. Finally, simulation results demonstrate the effectiveness of the proposed scheme.
Shoreline Delineation from Synthetic Aperture Radar (SAR) Imagery for High and Low Tidal States in Data-Deficient Niger Delta Region
Authors: Dike Emmanuel Chigozie , Oyetunji Abiodun Kolawole , Amaechi Chiemela Victor
Published: July 2023

Satellite image analysis is a potentially powerful tool for monitoring coastal shoreline positions. This study explores the use of multi-temporal, dual-polarised Sentinel-1 GRD synthetic aperture radar (SAR) imagery with a spatial resolution of 10 m for delineating shorelines. It was conducted in a data-deficient and complex environment (the Niger delta of Nigeria), in a developing country with a cloud-heavy climate. The study focuses on exploring and testing the capability of using multitemporal waterlines from SAR images to derive shoreline positions at high and low tidal states. From 54 Sentinel-1 images recorded in 2017, the study selected 12 images to represent both high and low tidal states. These were spread across the wet and dry seasons in order to account for seasonal differences. Shoreline positions were obtained by identifying the land–water boundary via segmentation using histogram-minimum thresholding, vectorizing and smoothing that boundary, and averaging its position over multiple waterlines. The land–water segmentation had an overall accuracy of 95–99%. It showed differences between wet and dry season shoreline positions in areas dominated by complex creek networks, but similarities along open coasts. The SAR-derived shorelines deviated from the reference lines by a maximum of 43 m (approximately four pixels), and often less than 10 m (one pixel) in most locations (open coast, estuarine, complex creek networks) at high and low tides, except low tide lines in areas with extensive inter-tidal flats at shorelines 70 m to 370 m from the reference lines. However, for applications such as coastal vulnerability assessment, the high tide shoreline is of greater importance. Thus, depending on the application of interest, problems with low tide shoreline delineation may be irrelevant. Despite limitations, notably the relatively small number of images available that were recorded at high or low tide, the method provides a simple, objective, and cost-effective approach to monitoring shorelines at high and low tide.
The Extracellular Lipopeptides and Volatile Organic Compounds of Bacillus subtilis DHA41 Display Broad-Spectrum Antifungal Activity against Soil-Borne Phytopathogenic Fungi
Authors: Al-Mutar Dhabyan Mutar Kareem , Noman Muhammad , Alzawar Noor Salih Abduljaleel , Qasim Hadi Hussein , Li Dayong , Song Fengming
Published: July 2023

Fusarium oxysporum f. sp. niveum (Fon) is a devastating soil-borne fungus causing Fusarium wilt in watermelon. The present study investigated the biochemical mechanism underlying the antifungal activity exhibited by the antagonistic bacterial strain DHA41, particularly against Fon. Molecular characterization based on the 16S rRNA gene confirmed that DHA41 is a strain of Bacillus subtilis, capable of synthesizing antifungal lipopeptides, such as iturins and fengycins, which was further confirmed by detecting corresponding lipopeptide biosynthesis genes, namely ItuB, ItuD, and FenD. The cell-free culture filtrate and extracellular lipopeptide extract of B. subtilis DHA41 demonstrated significant inhibitory effects on the mycelial growth of Fon, Didymella bryoniae, Sclerotinia sclerotiorum, Fusarium graminearum, and Rhizoctonia solani. The lipopeptide extract showed emulsification activity and inhibited Fon mycelial growth by 86.4% at 100 µg/mL. Transmission electron microscope observations confirmed that the lipopeptide extract disrupted Fon cellular integrity. Furthermore, B. subtilis DHA41 emitted volatile organic compounds (VOCs) that exhibited antifungal activity against Fon, D. bryoniae, S. sclerotiorum, and F. graminearum. These findings provide evidence that B. subtilis DHA41 possesses broad-spectrum antifungal activity against different fungi pathogens, including Fon, through the production of extracellular lipopeptides and VOCs.
Candida parapsilosis Sensu Stricto Antifungal Resistance Mechanisms and Associated Epidemiology
Authors: Franconi Iacopo , Rizzato Cosmeri , Poma Noemi , Tavanti Arianna , Lupetti Antonella
Published: July 2023

Fungal diseases cause millions of deaths per year worldwide. Antifungal resistance has become a matter of great concern in public health. In recent years rates of non-albicans species have risen dramatically. Candida parapsilosis is now reported to be the second most frequent species causing candidemia in several countries in Europe, Latin America, South Africa and Asia. Rates of acquired azole resistance are reaching a worrisome threshold from multiple reports as in vitro susceptibility testing is now starting also to explore tolerance and heteroresistance to antifungal compounds. With this review, the authors seek to evaluate known antifungal resistance mechanisms and their worldwide distribution in Candida species infections with a specific focus on C. parapsilosis.
Inventory of the Secondary Metabolite Biosynthetic Potential of Members within the Terminal Clade of the Fusarium solani Species Complex
Authors: Pokhrel Ambika , Coleman Jeffrey J.
Published: July 2023

The Fusarium solani species complex (FSSC) constitutes at least 77 phylogenetically distinct species including several agriculturally important and clinically relevant opportunistic pathogens. As with other Fusaria, they have been well documented to produce many secondary metabolites—compounds that are not required for the fungus to grow or develop but may be beneficial to the organism. An analysis of ten genomes from fungi within the terminal clade (clade 3) of the FSSC revealed each genome encoded 35 (F. cucurbitcola) to 48 (F. tenucristatum) secondary metabolite biosynthetic gene clusters (BGCs). A total of seventy-four different BGCs were identified from the ten FSSC genomes including seven polyketide synthases (PKS), thirteen nonribosomal peptide synthetases (NRPS), two terpene synthase BGCs, and a single dimethylallytryptophan synthase (DMATS) BGC conserved in all the genomes. Some of the clusters that were shared included those responsible for producing naphthoquinones such as fusarubins, a red pigmented compound, squalestatin, and the siderophores malonichrome, ferricrocin, and triacetylfusarinine. Eight novel NRPS and five novel PKS BGCs were identified, while BGCs predicted to produce radicicol, gibberellin, and fusaoctaxin were identified, which have not previously described in members of the FSSC. The diversity of the secondary metabolite repertoire of the FSSC may contribute to the expansive host range of these fungi and their ability to colonize broad habitats.
Manual Chest Compression versus Automated Chest Compression Device during Day-Time and Night-Time Resuscitation Following Out-of-Hospital Cardiac Arrest: A Retrospective Historical Control Study
Authors: Takayama Wataru , Endo Akira , Morishita Koji , Otomo Yasuhiro
Published: July 2023

Objective: We assessed the effectiveness of automated chest compression devices depending on the time of admission based on the frequency of iatrogenic chest injuries, the duration of in-hospital resuscitation efforts, and clinical outcomes among out-of-hospital cardiac arrest (OHCA) patients. Methods: We conducted a retrospective historical control study of OHCA patients in Japan between 2015–2022. The patients were divided according to time of admission, where day-time was considered 07:00–22:59 and night-time 23:00–06:59. These patients were then divided into two categories based on the in-hospital cardiopulmonary resuscitation (IHCPR) device: manual chest compression (mCC) group and automatic chest compression devices (ACCD) group. We used univariate and multivariate ordered logistic regression models adjusted for pre-hospital confounders to evaluate the impact of ACCD use during IHCPR on outcomes (IHCPR duration, CPR-related chest injuries, and clinical outcomes) in the day-time and night-time groups. Results: Among 1101 patients with OHCA (day-time, 809; night-time, 292), including 215 patients who underwent ACCD during IHCPR in day-time (26.6%) and 104 patients in night-time group (35.6%), the multivariate model showed a significant association of ACCD use with the outcomes of in-hospital resuscitation and higher rates of return in spontaneous circulation, lower incidence of CPR-related chest injuries, longer in-hospital resuscitation durations, greater survival to Emergency Department and hospital discharge, and greater survival with good neurological outcome to hospital discharge, though only in the night-time group. Conclusions: Patients who underwent ACCD during in-hospital resuscitation at night had a significantly longer duration of in-hospital resuscitation, a lower incidence of CPR-related chest injuries, and better outcomes.
Primary Thyroid Lymphoma: How Molecular Biology and Ancillary Techniques Can Help the Cytopathologist Overcome This Diagnostic Challenge
Authors: Guidobaldi Leo , Cafiero Concetta , D’Amato Gerardo , Dell’Aquila Marco , Trimboli Pierpaolo , Palmirotta Raffaele , Pisconti Salvatore
Published: July 2023

Primary thyroid lymphoma (PTL) occurs rarely, its diagnosis is a challenge, and the prognosis of these patients depends on the time of diagnosis. Even though fine-needle aspiration cytology (FNAC) is recognized as the most accurate tool for detecting thyroid malignancies, its sensitivity for PTL is poor. Both clinical and ultrasound presentation of PTL can be atypical, and laboratory tests fail to furnish relevant data. Consequently, the reliability of a cytopathologist facing PTL can be poor, even when he is aware of its clinical information. In addition, the cases described in the literature are extremely rare and fragmentary, and consequently, the molecular data currently available for this neoplasm are practically negligible. Here, we present a case report in order to discuss the intrinsic limitations in achieving a final diagnosis of PTL and how using molecular diagnostics to identify potential mutational models can improve the evaluation of this neoplasm.
Radiomics and Radiogenomics in Preclinical Imaging on Murine Models: A Narrative Review
Authors: Monti Serena , Truppa Maria Elena , Albanese Sandra , Mancini Marcello
Published: July 2023

Over the past decade, medical imaging technologies have become increasingly significant in both clinical and preclinical research, leading to a better understanding of disease processes and the development of new diagnostic and theranostic methods. Radiomic and radiogenomic approaches have furthered this progress by exploring the relationship between imaging characteristics, genomic information, and outcomes that qualitative interpretations may have overlooked, offering valuable insights for personalized medicine. Preclinical research allows for a controlled environment where various aspects of a pathology can be replicated in animal models, providing radiomic and radiogenomic approaches with the unique opportunity to investigate the causal connection between imaging and molecular factors. The aim of this review is to present the current state of the art in the application of radiomics and radiogenomics on murine models. This review will provide a brief description of relevant articles found in the literature with a discussion on the implications and potential translational relevance of these findings.
A Prospective Observational Study on the Role of Immunohistochemical Expression of Orphanin in Laryngeal Squamous Cell Carcinoma Recurrence
Authors: Sireci Federico , Lorusso Francesco , Dispenza Francesco , Immordino Angelo , Gallina Salvatore , Salvago Pietro , Martines Francesco , Bonaventura Giuseppe , Uzzo Maria Laura , Spatola Giovanni Francesco
Published: July 2023

To date, histological biomarkers expressed by laryngeal cancer are poorly known. The identification of biomarkers associated with laryngeal squamous cell carcinoma (SCC), would help explain the tumorogenesis and prevent the possible recurrence of the lesion after treatment. For this reason, the aim of this study is to investigate, for the first time, the Orphanin expression in 48 human specimens of laryngeal SCC and evaluate its possible correlation with patients prognosis. We analyzed pathological specimens from 48 patients with laryngeal SCC to detect the presence of Orphanin by using an immunohistochemistry test. We compared the findings with healthy tissue acquired from patients who underwent surgery for mesenchymal benign tumours of the larynx. The specimens were stained with anti-Orphanin monoclonal antibodies. Results were processed through a computerised image analysis system to determine a scale of staining intensity. All the tumoural specimens examined showed a significant immunoreaction for Orphanin when compared with healthy tissues (p < 0.05) but with a different immune reactivity related to clinical-pathological features. A high Orphanin expression was not significantly related to Histological Grading (HG), TNM, and stage (p > 0.05). In the multivariate analysis, the Orphanin expression was significantly related only to the malignant recurrence (p < 0.05). Our study suggests that Orphanin could have a role in tumorigenesis by increasing the recurrence of cancer; therefore, it should be further explored as a possible biomarker for laryngeal cancer.
Advancing Patient Care: How Artificial Intelligence Is Transforming Healthcare
Authors: Poalelungi Diana Gina , Musat Carmina Liana , Fulga Ana , Neagu Marius , Neagu Anca Iulia , Piraianu Alin Ionut , Fulga Iuliu
Published: July 2023

Artificial Intelligence (AI) has emerged as a transformative technology with immense potential in the field of medicine. By leveraging machine learning and deep learning, AI can assist in diagnosis, treatment selection, and patient monitoring, enabling more accurate and efficient healthcare delivery. The widespread implementation of AI in healthcare has the role to revolutionize patients’ outcomes and transform the way healthcare is practiced, leading to improved accessibility, affordability, and quality of care. This article explores the diverse applications and reviews the current state of AI adoption in healthcare. It concludes by emphasizing the need for collaboration between physicians and technology experts to harness the full potential of AI.
Correction: Rivera-Picón et al. Factors Associated with Adherence to Treatment in Patients with HIV and Diabetes Mellitus. J. Pers. Med. 2023, 13, 269
Authors: Rivera-Picón Cristina , Benavente-Cuesta María Hinojal , Quevedo-Aguado María Paz , Sánchez-González Juan Luis , Rodríguez-Muñoz Pedro Manuel
Published: July 2023

There was an error in the original publication [...]
Influence of Intercity Network on Land Comprehensive Carrying Capacity: A Perspective of Population Flow
Authors: Shi Xiang , Yu Xiao , Wang Shijun , Hao Feilong
Published: July 2023

The world is experiencing the largest wave of urban growth in history. Maintaining the rapid growth of cities without causing land and resource shortages is a severe problem that must be solved urgently. With the rapid development of globalization and information technology, the meaning of land comprehensive carrying capacity presents new changes. It is no longer entirely dependent on local resources and is likely to benefit from intercity connections beyond urban boundaries. However, can an inter-city network be a non-local solution to sustain urban growth without increasing land pressure? To address this question, this study adopted 287 cities in China as the research object to describe the spatial carrying characteristics of land at the national level by constructing an evaluation index system for land comprehensive carrying capacity. Furthermore, we constructed a population flow network model through social network analysis to explore the influence of intercity network on land comprehensive carrying capacity. Our findings are as follows: (1) The regional differentiation characteristics of land comprehensive carrying capacity at the national scale are evident, and reveal a spatial pattern significantly related to the urban economic development level. (2) The weighted in-degree, weighted degree centrality, and betweenness centrality in the intercity network positively impact the land comprehensive carrying capacity, and land use efficiency has a partial mediating effect. (3) Land comprehensive carrying capacity can be determined by non-local factors rather than local factors. As an effective non-local channel, strengthening intercity population flow and network integration can flexibly manage urban land scarcity.
Rights-Based Approaches to Environmental Protection and Pandemic Prevention
Authors: Rudall Jason
Published: July 2023

This article reflects on the proposed pandemic treaty negotiations, the content of the recently published Zero Draft and its prospects for success in preventing future pandemics from emerging at all. It argues that, as presently conceived, the proposed instrument does little to address environmental damage as the primary driver of zoonotic spillover, nor does it make sufficient provision for the implementation and enforcement of legal obligations. In particular, the piece suggests that human rights and rights of nature can and should feature more prominently in efforts to fully realize the One Health agenda and strengthen environmental governance with a view to mitigating the risk of future pandemics. Experience from rights-based approaches in other contexts suggests that they offer a promising conduit for achieving genuine policy reform and accountability regarding environmental degradation. Indeed, human rights and rights of nature can play an important role in mitigating ecological destruction, biodiversity loss and, in turn, preventing disease transmission from the natural world.
Legal Framework for Social Infrastructure for Social Integration of the Roma and Their Preferences: Case of Slovenia
Authors: Sluga Andrej , Bogataj David , Drobež Eneja
Published: July 2023

The EU and its Member States share responsibility for improving the living conditions and integration of the Roma into society. When developing systemic solutions to address the challenges of the Roma population, the first thing to do is to provide them with a suitable living environment. A suitable living environment for vulnerable social groups includes social housing adapted to their needs and preferences as part of the social infrastructure. In the first, theoretical part, this paper explores the existing international, EU, and Slovenian legal framework for addressing the housing needs of the Roma community. In the second, empirical part, the preferences of the members of the Roma Community regarding the type and architecture of housing, and their financial capacity regarding the type and location of accommodation are examined through a survey that was conducted in the Roma settlement “Kerinov Grm”. The research paper gives answers to the following research questions: (1) what are the preferences of the inhabitants of Roma settlements regarding the type of housing and architecture? (2) how to provide adequate housing for members of the Roma community? and (3) do the Roma take advantage of the available free non-profit housing, and if not, why? The survey shows a very low level of satisfaction with living in Roma settlements, which, in combination with the growing population, limited possibilities for settlement expansion, and specific housing preferences, poses a unique challenge to the state and local communities.
Obesity-Related Knee Osteoarthritis—Current Concepts
Authors: Shumnalieva Russka , Kotov Georgi , Monov Simeon
Published: July 2023

The knee is the joint most frequently involved in osteoarthritis and represents a significant contributor to patient morbidity and impaired functional status. Major risk factors include genetics, age, sex, mechanical load and obesity/metabolic syndrome. Recent studies highlighted the role of obesity and metabolic syndrome in the pathogenesis of knee osteoarthritis not simply through increased mechanical loading but the systemic effects of obesity-induced inflammation. The current concept of knee osteoarthritis is that of a ‘whole joint disease’, which highlights the involvement not only of articular cartilage but also the synovium, subchondral bone, ligaments and muscles. Obesity and metabolic syndrome are associated with higher levels of pro-inflammatory cytokines, increased production of adipokines with both protective and destructive effects on articular cartilage, an up-regulation of proteolytic enzymes such as matrix metalloproteinases and aggrecanases and an increase in free fatty acids and reactive oxygen species induced by dyslipidemia. These findings underscore that the adequate management of knee osteoarthritis needs to include an optimization of body weight and a beneficial mobility regimen. The possible introduction of pharmacological therapy targeting specific molecules involved in the pathogenesis of obesity-related osteoarthritis will likely also be considered in future therapeutic strategies, including personalized treatment approaches.
Subcutaneous Implantable Cardioverter Defibrillator: A Contemporary Overview
Authors: Guarracini Fabrizio , Preda Alberto , Bonvicini Eleonora , Coser Alessio , Martin Marta , Quintarelli Silvia , Gigli Lorenzo , Baroni Matteo , Vargiu Sara , Varrenti Marisa , Forleo Giovanni Battista , Mazzone Patrizio , Bonmassari Roberto , Marini Massimiliano , Droghetti Andrea
Published: July 2023

The difference between subcutaneous implantable cardioverter defibrillators (S-ICDs) and transvenous ICDs (TV-ICDs) concerns a whole extra thoracic implantation, including a defibrillator coil and pulse generator, without endovascular components. The improved safety profile has allowed the S-ICD to be rapidly taken up, especially among younger patients. Reports of its role in different cardiac diseases at high risk of SCD such as hypertrophic and arrhythmic cardiomyopathies, as well as channelopathies, is increasing. S-ICDs show comparable efficacy, reliability, and safety outcomes compared to TV-ICD. However, some technical issues (i.e., the inability to perform anti-bradycardia pacing) strongly limit the employment of S-ICDs. Therefore, it still remains only an alternative to the traditional ICD thus far. This review aims to provide a contemporary overview of the role of S-ICDs compared to TV-ICDs in clinical practice, including technical aspects regarding device manufacture and implantation techniques. Newer outlooks and future perspectives of S-ICDs are also brought up to date.
Antioxidant and Anti-Inflammatory Activities of Stellera chamaejasme L. Roots and Aerial Parts Extracts
Authors: Selenge Temuulen , Vieira Sara F. , Gendaram Odontuya , Reis Rui L. , Tsolmon Soninkhishig , Tsendeekhuu Enkhtuul , Ferreira Helena , Neves Nuno M.
Published: July 2023

Natural products, mainly plants, have a crucial role in folk medicine. Particularly, Stellera chamaejasme L. has been traditionally used in Mongolian medicine to treat various diseases, including chronic tracheitis, tuberculosis, and psoriasis. In this study, ethanol (EtOH) and dichloromethane (DCM) extracts of its roots (R) and aerial parts (AP) were evaluated for their antioxidant and anti-inflammatory activities. Thin-layer chromatography demonstrated the presence of flavonoids, namely kaempferol and quercetin-3-O-glucopyranoside, only in the EtOH-AP. Conversely, it showed that kaempferol, quercetin-3-O-glucopyranoside, coumarin, luteolin, rutin, morin, and riboflavin were not present in the other three extracts. The S. chamaejasme extracts exhibited strong antioxidant activity. In addition, the roots extracts presented the highest antioxidant activity against peroxyl radicals, with the EtOH-R being the most potent (IC50 = 0.90 ± 0.07 µg/mL). S. chamaejasme extracts also efficiently inhibited the production of one of the main pro-inflammatory cytokines, interleukin (IL)-6, in a dose-dependent manner by lipopolysaccharide-stimulated macrophages. Particularly, DCM-R was the strongest extract, reducing ≈ 91.5% of the IL-6 production. Since this extract was the most effective, gas chromatography–mass spectrometry (GC-MS) analyses were performed and demonstrated the presence of two fatty acids (palmitic acid and 9-octadecenoic acid), one fatty alcohol (1-hexadecanol), and one triterpenoid (squalene) that can contribute to the observed bioactivity. Herewith, S. chamaejasme extracts, mainly DCM-R, exhibit antioxidant and anti-inflammatory activities that could be applied as new and innovative natural formulations for the treatment of chronic inflammatory diseases.
Sinonasal Orbital Apex Syndrome, Horner Syndrome and Pterygopalatine Fossa Infection: A Case Report and Mini-Review
Authors: Benites Gregorio , Urbančič Jure , Bardales Carolina , Vozel Domen
Published: July 2023

This paper presents a literature review and a case of an 83-year-old otherwise healthy female patient with a history of recent syncope, a sudden-onset right-sided temporal headache, diplopia, and vision loss. An exam revealed right-sided upper eyelid ptosis, myosis, vision loss, ophthalmoplegia, and a positive relative afferent pupillary defect on the right eye. CT showed sphenoid sinus opacification, eroded lateral sinus wall, Vidian canal, disease extension to the posterior ethmoid air cells, orbital apex, medial orbital wall, and pterygopalatine fossa. An orbital apex syndrome (Jacod’s syndrome), Horner syndrome, and pterygopalatine fossa infection were diagnosed due to the acute invasive fungal sinusitis developed from a sphenoid sinus fungal ball. The patient was treated with antimicrobial therapy and transnasal endoscopic surgery twice to decompress the orbital apex, drain the abscess and obtain specimens for analysis. The right-sided ptosis, visual loss, ophthalmoplegia, and headache resolved entirely. No immune or comorbid diseases were identified, microbiological and histopathological analyses were negative, and MRI could not be performed on the presented patient. For that reason, the diagnostic procedure was non-standard. Nevertheless, the treatment outcome of this vision and life-threatening disease was satisfactory. Treating the fungal ball in an older or immunocompromised patient is essential to prevent invasive fungal rhinosinusitis and fatal complications.
Presence of p25alpha-Domain in Seed Plants (Spermatophyta): Microbial/Animal Contaminations and/or Orthologs
Authors: Orosz Ferenc
Published: July 2023

Genome and transcriptome assembly data often contain DNA and RNA contaminations from external organisms, introduced during nucleotide extraction or sequencing. In this study, contamination of seed plant (Spermatophyta) transcriptomes/genomes with p25alpha domain encoding RNA/DNA was systematically investigated. This domain only occurs in organisms possessing a eukaryotic flagellum (cilium), which seed plants usually do not have. Nucleotide sequences available at the National Center for Biotechnology Information website, including transcriptome shotgun assemblies (TSAs), whole-genome shotgun contigs (WGSs), and expressed sequence tags (ESTs), were searched for sequences containing a p25alpha domain in Spermatophyta. Despite the lack of proteins containing the p25alpha domain, such fragments or complete mRNAs in some EST and TSA databases were found. A phylogenetic analysis showed that these were contaminations whose possible sources were microorganisms (flagellated fungi, protists) and arthropods/worms; however, there were cases where it cannot be excluded that the sequences found were genuine hits and not of external origin.
Review of Recent Prevalence of Urogenital Schistosomiasis in Sub-Saharan Africa and Diagnostic Challenges in the Field Setting
Authors: Hong Sung-Tae
Published: July 2023

Human schistosomiasis is one of neglected tropical diseases that remain highly prevalent in sub-Saharan Africa (SSA). Human schistosomiasis is mainly caused by two species, Schistosoma haematobium and S. mansoni, leading to urogenital and intestinal schistosomiasis, respectively. The World Health Organization (WHO) recommends mass drug administration (MDA) with praziquantel as the primary method of global intervention. Currently, MDA with praziquantel covers over half of the target population in endemic SSA countries. However, an accurate diagnosis is crucial for monitoring and evaluating the effectiveness of MDA. The standard diagnosis of both urogenital and intestinal schistosomiasis relies on the microscopic identification of eggs. However, the diagnostic sensitivity of this approach is low, especially for light or ultra-light infections. This is because Schistosoma eggs are laid inside of the venous plexus of the urinary bladder or mesenteric vein, where the adult flukes live. Approximately half of the eggs circulate in the blood vessels or are packed in neighboring tissues, while the remaining half are expelled into the lumen of the urinary bladder or intestine intermittently when the blood vessels are ruptured. In the field setting, the accuracy of any diagnostic method is critical for proper management of the intervention. The present article reviews the recent prevalence of urogenital schistosomiasis in SSA and highlights the practical limitations of diagnostic methods such as urine microscopy, urine reagent strips, molecular diagnosis, and ultrasound scanning in the field setting. Despite continuous global efforts to eliminate schistosomiasis over the past 20 years, many areas still remain endemic in SSA. No single diagnostic approach achieves acceptable sensitivity and specificity in the field setting. Therefore, any field survey should employ a combination of these methods based on the purpose of the study to accurately monitor and evaluate urogenital schistosomiasis. Based on diagnostic values and a cost–benefit analysis, a urine reagent strip test can replace urine microscopy in the field setting. The WHO criteria by ultrasound diagnosis should be updated including the echogenic snow sign and contour distortion.
A Bi-Objective Mixed-Integer Linear Programming Model for a Sustainable Agro-Food Supply Chain with Product Perishability and Environmental Considerations
Authors: Azab Rana , Mahmoud Rana S. , Elbehery Rahma , Gheith Mohamed
Published: July 2023

Background: Agro-food supply chains possess specific characteristics due to the diverse nature of products involved and contribute to all three pillars of sustainability, making the optimal design of a sustainable agro-food supply chain a complex problem. Therefore, efficient models incorporating the unique characteristics of such chains are essential for making optimal supply chain decisions and achieving economically and environmentally sustainable agro-food supply chains that contribute to global food security. Methods: This article presents a multi-objective mixed-integer linear programing model that integrates agricultural-related strategic decisions into the tactical design of an agro-food supply chain. The model considers transportation, inventory, processing, demand fulfilment, and waste disposal decisions. It also accounts for seasonality and perishability, ensuring a comprehensive approach to sustainability. The model aims to maximize the total generated profits across the supply chain while simultaneously minimizing CO2 emissions as a measure of environmental impact. Results: By implementing the model on a sugar beet supply chain in the Netherlands, strategic crop rotation farm schedules for the crop rotation cycle and the optimum supply network decisions are obtained. Furthermore, different objectives are analyzed and the Pareto-efficient frontier is investigated to analyze the underlying trade-offs. Additionally, the model serves as a decision support tool for managers facilitating informed investment decisions in technologies that prolong product shelf life while maintaining profitability. Conclusions: The proposed multi-objective model offers a valuable framework for designing economically and environmentally sustainable agro-food supply chains. By aligning with sustainability goals and providing decision support, this research contributes to enhancing global food security and promoting sustainable resource utilization.
Evaluation of Effective Composite Biosorbents Based on Wood Sawdust and Natural Clay for Heavy Metals Removal from Water
Authors: Del Sole Roberta , Fogel Alena A. , Somin Vladimir A. , Vasapollo Giuseppe , Mergola Lucia
Published: July 2023

Bentonitic clay and wood sawdust are natural materials widely available in nature at low cost with high heavy metals sorption properties that, in this work, were combined to achieve an effective composite biosorbent with high sorption properties and enhanced mechanical stability. Pine, aspen, and birch wood sawdust, as well as different bentonite clays and different sawdust modification methods (H3PO4 or HCl) were used for preparing new composite biosorbents. A mixture of wood sawdust and bentonite in a ratio of 2:1 was used. All materials were characterized by using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and scanning electron microscope (SEM) methods and tested for Cu and Ni ions removal from water. The adsorption process for all composite biosorbents was well described from a pseudo-second order kinetic model (R2 > 0.9999) with a very high initial adsorption rate of Cu and Ni ions and a maximum uptake recorded within 2 h. The results have shown that the adsorption capacity depends mainly on the kind of wood and the acid treatment of the wood that enhances the adsorption capacity. At a concentration of 50 mg/L, the biosorbent prepared using birch wood sawdust showed the worst performance, removing barely 30% of Cu and Ni ions, while aspen wood sawdust improved the adsorption of Cu (88.6%) and Ni (52.4%) ions. Finally, composite biosorbent with pine wood sawdust showed the best adsorption be haviour with an efficiency removal of 98.2 and 96.3% of Cu and Ni ions, respectively, making it a good candidate as an inexpensive and effective biosorbent for the removal of heavy metals.
3D Printing of Layered Structures of Metal-Ionic Polymers: Recent Progress, Challenges and Opportunities
Authors: Martinelli Angelo , Nitti Andrea , Po Riccardo , Pasini Dario
Published: July 2023

Layered Structures of Metal Ionic Polymers, or Ionic Polymer-Metal Composites (IPMCs) are formed by a membrane of an ionic electroactive materials flanked by two metal electrodes on both surfaces; they are devices able to change their shape upon application of an electrical external stimulus. This class of materials is used in various fields such as biomedicine, soft robotics, and sensor technology because of their favorable properties (light weight, biocompatibility, fast response to stimulus and good flexibility). With additive manufacturing, actuators can be customized and tailored to specific applications, allowing for the optimization of performance, size, and weight, thus reducing costs and time of fabrication and enhancing functionality and efficiency in various applications. In this review, we present an overview of the newest trend in using different 3D printing techniques to produce electrically responsive IPMC devices.
Experimental Study on the Effect of an Organic Matrix on Improving the Strength of Tailings Strengthened by MICP
Authors: Hu Lin , Zheng Huaimiao , Wu Lingling , Zhang Zhijun , Yu Qing , Tian Yakun , He Guicheng
Published: July 2023

In order to improve the effect of microbial-induced calcium carbonate precipitation (MICP) in tailings reinforcement, sodium citrate, an organic matrix with good water solubility, was selected as the crystal form adjustment template for inducing calcium carbonate crystallization, and the reinforcements of tailings by MICP were conducted in several experiments. The effects of sodium citrate on the yield, crystal form, crystal appearance, and distribution of calcium carbonate were analyzed by MICP solution test; thus, the related results were obtained. These showed that the addition of a proper amount of organic matrix sodium citrate could result in an increment in the yield of calcium carbonate. The growth rate of calcium carbonate reached 22.6% under the optimum amount of sodium citrate, and the crystals of calcium carbonate were diverse and closely arranged. Based on this, the MICP reinforcement test of tailings was carried out under the action of the optimum amount of sodium citrate. The microscopic analysis using CT and other means showed that the calcium carbonate is distributed more uniformly in tailings, and the porosity of samples is significantly reduced by layered scanning analysis. The results of triaxial shear tests showed that adding organic matrix sodium citrate effectively increased the cohesion, internal friction angle, and peak stress of the reinforced tailings. It aims to provide a novel idea, a creative approach, and a method to enhance the reinforcement effect of tailings and green solidification technology in the mining environment.
High-Pressure Synthesis of Cubic ZnO and Its Solid Solutions with MgO Doped with Li, Na, and K
Authors: Taibarei Nikolai O. , Kytin Vladimir G. , Konstantinova Elizaveta A. , Kulbachinskii Vladimir A. , Savilov Serguei V. , Mukhanov Vladimir A. , Solozhenko Vladimir L. , Brazhkin Vadim V. , Baranov Andrei N.
Published: July 2023

The possibility of doping ZnO in its metastable rock salt structure with Li, Na, and K intended to act as acceptor dopants was investigated. For the first time, MgxZn1−xO alloys and pure ZnO with a rock salt structure doped with Li, Na, and K metals was obtained by high-pressure synthesis from pure oxides with the addition of carbonates or acetates of the corresponding metals as dopant sources. Successful stabilization of the metastable rock salt structure and phase purity were confirmed by X-ray diffraction. Transmission electron microscopy was used to study the particle size of nanocrystalline precursors, while the presence of Li, Na, and K metals in rock salt ZnO was detected by electron energy-loss spectroscopy and X-ray photoelectron spectroscopy in MgxZn1−xO alloys. Electron paramagnetic resonance measurements revealed the acceptor behavior of Li, Na, and K dopants based on the influence of the latter on native defects and natural impurities in ZnO-MgO alloys. In addition, diffuse reflectance spectroscopy was used to derive band gaps of quenched rock salt ZnO and its alloys with MgO.
Adsorption of Sc on the Surface of Kaolinite (001): A Density Functional Theory Study
Authors: Zhao Zilong , Wang Kaiyu , Wu Guoyuan , Jiang Dengbang , Lan Yaozhong
Published: July 2023

The adsorption behavior of Sc on the surface of kaolinite (001) was investigated using the density functional theory via the generalized gradient approximation plane-wave pseudopotential method. The highest coordination numbers of hydrated Sc3+,  ScOH2+, and  ScOH2 + species are eight, six, and five, respectively. The adsorption model was based on ScOH2H2O5+, which has the most stable ionic configuration in the liquid phase. According to the adsorption energy and bonding mechanism, the adsorption of Sc ionic species can be categorized into outer layer and inner layer adsorptions. We found that the hydrated Sc ions were mainly adsorbed on the outer layer of the kaolinite (001)Al-OH and (00−1)Si-O surfaces through hydrogen bonding while also being adsorbed on the inner layer of the deprotonated kaolinite (001)Al-OH surface through coordination bonding. The inner layer adsorption has three adsorption configurations, with the lying hydroxyl group (Ol) position having the lowest adsorption energy (−653.32 KJ/mol). The adsorption energy for the inner layer is lower compared to the outer layer, while the extent of deprotonation is limited. This is because the deprotonation of the inner adsorption layer is energetically unfavorable. We speculate that Sc ions species predominantly adsorb onto the surface of kaolinite (001) in an outer layer configuration.
The Out-Of-Plane Compression Behavior of In Situ Ethylene Vinyl Acetate (EVA)-Foam-Filled Aluminum Honeycomb Sandwich Structures
Authors: Atalay Kalsen Tuğba Selcen , Karadağ Hakan Burak , Eker Yasin Ramazan
Published: July 2023

In this study, the mechanical behavior of aluminum honeycomb (AHC) sandwich structures filled with ethylene vinyl acetate copolymer (EVA) foam in situ under out-of-plane compression loading was investigated experimentally. Both non-filled and EVA-foam-filled sandwich specimens with three different AHC core cell sizes (5.20, 6.78, and 8.66 mm) were studied to correlate the foam-filling effect with a key structural parameter. The results showed that compression characteristic properties such as peak stress, plateau stress, and absorbed energy per unit volume of the sandwich structure increased with EVA foam filling. The structure showed high recoverability when the compression loading was removed due to the viscoelastic nature of EVA foam. Cored EVA sandwich with 8.66 mm AHC cell size was recovered at 44% of the original thickness. This result promises groundbreaking applications such as impact-resistant and self-healing structures. The microstructures were also observed using scanning electron microscopy (SEM) to investigate the failure and the recoverability mechanisms.
Synergistic Effect of Precursor and Interface Engineering Enables High Efficiencies in FAPbI3 Perovskite Solar Cells
Authors: Sahayaraj Sylvester , Starowicz Zbigniew , Ziółek Marcin , Socha Robert , Major Łukasz , Góral Anna , Gawlińska-Nęcek Katarzyna , Palewicz Marcin , Sikora Andrzej , Piasecki Tomasz , Gotszalk Teodor , Lipiński Marek
Published: July 2023

Formamidinium lead iodide (FAPbI3)-based perovskite solar cells have gained immense popularity over the last few years within the perovskite research community due to their incredible opto-electronic properties and the record power conversion efficiencies (PCEs) achieved by the solar cells. However, FAPbI3 is vulnerable to phase transitions even at room temperature, which cause structural instability and eventual device failure during operation. We performed post-treatment of the FAPbI3 surface with octyl ammonium iodide (OAI) in order to stabilize the active phase and preserve the crystal structure of FAPbI3. The formation of a 2D perovskite at the interface depends on the stoichiometry of the precursor. By optimizing the precursor stoichiometry and the concentration of OAI, we observe a synergistic effect, which results in improved power conversion efficiencies, reaching the best values of 22% on a glass substrate. Using physical and detailed optical analysis, we verify the presence of the 2D layer on the top of the 3D surface of the perovskite film.
Investigation of the Impact of High-Speed Machining in the Milling Process of Titanium Alloy on Tool Wear, Surface Layer Properties, and Fatigue Life of the Machined Object
Authors: Matuszak Jakub , Zaleski Kazimierz , Zyśko Andrzej
Published: July 2023

This article presents the results of experimental research on the effect of high-speed machining (HSM) in the milling process on the tool wear, surface layer properties, and fatigue life of objects made of Ti-6Al-4V titanium alloy. Titanium alloys are widely used in many industries due to their high strength-to-density ratio, corrosion resistance, and resistance to dynamic loads. The experiment was conducted on a vertical three-axis machining centre, Avia VMC800HS. The influence of increased cutting speeds on the average values and amplitudes of the total cutting force components and the surface roughness of the machined workpiece was determined. Variable cutting speeds vc = 70; 130; 190; 250; 310 m/min were applied. The impact of HSM on machinability indicators, such as the microhardness of the surface layer, the distribution of residual stresses, and the fatigue life of the samples after milling, was analysed. The thickness of the hardened layer varied from 20 to 28 micrometres. The maximum compressive residual stress Ϭm = 190 MPa was achieved at the speed of vc = 190 m/min. A significant influence of increased cutting speeds on tool wear was demonstrated. The longest tool life (t = 70 min) was obtained for low cutting speeds (conventional) vc = 70 m/min.