bluuebunny/crossref_metadata_2025 huggingface dataset:
Predictors of success in establishing orthotopic patient-derived xenograft models of triple negative breast cancer
Authors: Echeverria Gloria V. , Cai Shirong , Tu Yizheng , Shao Jiansu , Powell Emily , Redwood Abena B. , Jiang Yan , McCoy Aaron , Rinkenbaugh Amanda L. , Lau Rosanna , Trevarton Alexander J. , Fu Chunxiao , Gould Rebekah , Ravenberg Elizabeth E. , Huo Lei , Candelaria Rosalind , Santiago Lumarie , Adrada Beatriz E. , Lane Deanna L. , Rauch Gaiane M. , Yang Wei T. , White Jason B. , Chang Jeffrey T. , Moulder Stacy L. , Symmans W. Fraser , Hilsenbeck Susan G. , Piwnica-Worms Helen
Published: January 2023

Patient-derived xenograft (PDX) models of breast cancer are an effective discovery platform and tool for preclinical pharmacologic testing and biomarker identification. We established orthotopic PDX models of triple negative breast cancer (TNBC) from the primary breast tumors of patients prior to and following neoadjuvant chemotherapy (NACT) while they were enrolled in the ARTEMIS trial (NCT02276443). Serial biopsies were obtained from patients prior to treatment (pre-NACT), from poorly responsive disease after four cycles of Adriamycin and cyclophosphamide (AC, mid-NACT), and in cases of AC-resistance, after a 3-month course of different experimental therapies and/or additional chemotherapy (post-NACT). Our study cohort includes a total of 269 fine needle aspirates (FNAs) from 217 women, generating a total of 62 PDX models (overall success-rate = 23%). Success of PDX engraftment was generally higher from those cancers that proved to be treatment-resistant, whether poorly responsive to AC as determined by ultrasound measurements mid-NACT (p = 0.063), RCB II/III status after NACT (p = 0.046), or metastatic relapse within 2 years of surgery (p = 0.008). TNBC molecular subtype determined from gene expression microarrays of pre-NACT tumors revealed no significant association with PDX engraftment rate (p = 0.877). Finally, we developed a statistical model predictive of PDX engraftment using percent Ki67 positive cells in the patient’s diagnostic biopsy, positive lymph node status at diagnosis, and low volumetric reduction of the patient’s tumor following AC treatment. This novel bank of 62 PDX models of TNBC provides a valuable resource for biomarker discovery and preclinical therapeutic trials aimed at improving neoadjuvant response rates for patients with TNBC.
Predicting lattice thermal conductivity via machine learning: a mini review
Authors: Luo Yufeng , Li Mengke , Yuan Hongmei , Liu Huijun , Fang Ying
Published: January 2023

Over the past few decades, molecular dynamics simulations and first-principles calculations have become two major approaches to predict the lattice thermal conductivity (κL), which are however limited by insufficient accuracy and high computational cost, respectively. To overcome such inherent disadvantages, machine learning (ML) has been successfully used to accurately predictκLin a high-throughput style. In this review, we give some introductions of recent ML works on the direct and indirect prediction ofκL, where the derivations and applications of data-driven models are discussed in details. A brief summary of current works and future perspectives are given in the end.
InvitroSPI and a large database of proteasome-generated spliced and non-spliced peptides
Authors: Roetschke Hanna P. , Rodriguez-Hernandez Guillermo , Cormican John A. , Yang Xiaoping , Lynham Steven , Mishto Michele , Liepe Juliane
Published: January 2023

Noncanonical epitopes presented by Human Leucocyte Antigen class I (HLA-I) complexes to CD8+ T cells attracted the spotlight in the research of novel immunotherapies against cancer, infection and autoimmunity. Proteasomes, which are the main producers of HLA-I-bound antigenic peptides, can catalyze both peptide hydrolysis and peptide splicing. The prediction of proteasome-generated spliced peptides is an objective that still requires a reliable (and large) database of non-spliced and spliced peptides produced by these proteases. Here, we present an extended database of proteasome-generated spliced and non-spliced peptides, which was obtained by analyzing in vitro digestions of 80 unique synthetic polypeptide substrates, measured by different mass spectrometers. Peptides were identified through invitroSPI method, which was validated through in silico and in vitro strategies. The peptide product database contains 16,631 unique peptide products (5,493 non-spliced, 6,453 cis-spliced and 4,685 trans-spliced peptide products), and a substrate sequence variety that is a valuable source for predictors of proteasome-catalyzed peptide hydrolysis and splicing. Potential artefacts and skewed results due to different identification and analysis strategies are discussed.
Solid-phase synthesis and pathological evaluation of pyroglutamate amyloid-β3-42 peptide
Authors: Cho Illhwan , Lee HeeYang , Lee Donghee , Park In Wook , Yoon Soljee , Kim Hye Yun , Kim YoungSoo
Published: January 2023

Pyroglutamate amyloid-β3-42 (AβpE3-42) is an N-terminally truncated and pyroglutamate-modified Aβ peptide retaining highly hydrophobic, amyloidogenic, and neurotoxic properties. In Alzheimer’s disease (AD) patients, AβpE3-42 peptides accumulate into oligomers and induce cellular toxicity and synaptic dysfunction. AβpE3-42 aggregates further seed the formation of amyloid plaques, which are the pathological hallmarks of AD. Given that AβpE3-42 peptides play critical roles in the development of neurodegeneration, a reliable and reproducible synthetic access to these peptides may support pathological and medicinal studies of AD. Here, we synthesized AβpE3-42 peptides through the microwave-assisted solid-phase peptide synthesis (SPPS). Utilizing thioflavin T fluorescence assay and dot blotting analysis with anti-amyloid oligomer antibody, the amyloidogenic activity of synthesized AβpE3-42 peptides was confirmed. We further observed the cytotoxicity of AβpE3-42 aggregates in cell viability test. To examine the cognitive deficits induced by synthetic AβpE3-42 peptides, AβpE3-42 oligomers were intracerebroventricularly injected into imprinting control region mice and Y-maze and Morris water maze tests were performed. We found that AβpE3-42 aggregates altered the expression level of postsynaptic density protein 95 in cortical lysates. Collectively, we produced AβpE3-42 peptides in the microwave-assisted SPPS and evaluated the amyloidogenic and pathological function of the synthesized peptides.
Activity networks determine project performance
Authors: Vazquez Alexei , Pozzana Iacopo , Kalogridis Georgios , Ellinas Christos
Published: January 2023

Projects are characterised by activity networks with a critical path, a sequence of activities from start to end, that must be finished on time to complete the project on time. Watching over the critical path is the project manager’s strategy to ensure timely project completion. This intense focus on a single path contrasts the broader complex structure of the activity network, and is due to our poor understanding on how that structure influences this critical path. Here, we use a generative model and detailed data from 77 real world projects (+ $10 bn total budget) to demonstrate how this network structure forces us to look beyond the critical path. We introduce a duplication-split model of project schedules that yields (i) identical power-law in- and-out degree distributions and (ii) a vanishing fraction of critical path activities with schedule size. These predictions are corroborated in real projects. We demonstrate that the incidence of delayed activities in real projects is consistent with the expectation from percolation theory in complex networks. We conclude that delay propagation in project schedules is a network property and it is not confined to the critical path.
Development and validation of a prognostic nomogram for Takotsubo syndrome patients in the intensive care units: a retrospective cohort study
Authors: Chen Jun , Wang Yimin , Shou Xinyang , Liu Qiang , Mei Ziwei
Published: January 2023

Patients with Takotsubo syndrome (TTS) admitted to the intensive care unit (ICU) always confront a higher risk of in-hospital death than those hospitalized in the cardiology unit. The prognosis of the latter was analyzed by a large number of studies. However, there was no utility model to predict the risk of in-hospital death for patients with TTS in the ICU. This study aimed to establish a model predicting in-hospital death in patients with TTS admitted to ICU. We retrospectively included ICU patients with TTS from the MIMIC-IV database. The outcome of the nomogram was in-hospital death. Least Absolute Shrinkage Selection Operator (LASSO) analysis selected predictors preliminarily. The model was developed by multivariable logistic regression analysis. Calibration, decision curve analysis (DCA), and receiver operating characteristic (ROC) measured the performance of the nomogram on the accuracy, clinical utility, and discrimination, respectively. Eventually, 368 ICU patients with TTS were enrolled in this research. The in-hospital mortality was 13.04%. LASSO regression and multivariate logistic regression analysis verified risk factors significantly associated with in-hospital mortality. They were potassium, prothrombin time (PT), age, myocardial infarction, white cell count (WBC), hematocrit, anion gap, and sequential organ failure assessment (SOFA) score. This nomogram excellently discriminated against patients with a risk of in-hospital death. The area under curve (AUC) was 0.779 (95%CI: 0.732–0.826) in training set and 0.775 (95%CI: 0.711–0.839) in test set. The calibration plot and DCA showed good clinical benefits for this nomogram. We developed a nomogram that predicts the probability of in-hospital death for ICU patients with TTS. This nomogram was able to discriminate patients with a high risk of in-hospital death and performed clinical utility.
Partial wavelet coherence as a robust method for assessment of neurovascular coupling in neonates with hypoxic ischemic encephalopathy
Authors: Hermans Tim , Carkeek Katherine , Dereymaeker Anneleen , Jansen Katrien , Naulaers Gunnar , Van Huffel Sabine , De Vos Maarten
Published: January 2023

In neonates with hypoxic ischemic encephalopathy, the computation of wavelet coherence between electroencephalogram (EEG) power and regional cerebral oxygen saturation (rSO2) is a promising method for the assessment of neurovascular coupling (NVC), which in turn is a promising marker for brain injury. However, instabilities in arterial oxygen saturation (SpO2) limit the robustness of previously proposed methods. Therefore, we propose the use of partial wavelet coherence, which can eliminate the influence of SpO2. Furthermore, we study the added value of the novel NVC biomarkers for identification of brain injury compared to traditional EEG and NIRS biomarkers. 18 neonates with HIE were monitored for 72 h and classified into three groups based on short-term MRI outcome. Partial wavelet coherence was used to quantify the coupling between C3–C4 EEG bandpower (2–16 Hz) and rSO2, eliminating confounding effects of SpO2. NVC was defined as the amount of significant coherence in a frequency range of 0.25–1 mHz. Partial wavelet coherence successfully removed confounding influences of SpO2 when studying the coupling between EEG and rSO2. Decreased NVC was related to worse MRI outcome. Furthermore, the combination of NVC and EEG spectral edge frequency (SEF) improved the identification of neonates with mild vs moderate and severe MRI outcome compared to using EEG SEF alone. Partial wavelet coherence is an effective method for removing confounding effects of SpO2, improving the robustness of automated assessment of NVC in long-term EEG-NIRS recordings. The obtained NVC biomarkers are more sensitive to MRI outcome than traditional rSO2 biomarkers and provide complementary information to EEG biomarkers.
The pre-surgical role of halo-traction in patients with cervical infection associated with refractory kyphosis: a retrospective study
Authors: Manini Daudi R. , Zhang Hong-Qi , Gao Qile , Liu Shao-Hua , YuXiang Wang , Tang Ming-Xing , An Deng , Guo Chao-Feng , YuXuan Du
Published: January 2023

To minimize surgical complications and staged procedures halo-traction is often used during deformity corrections. But the use of halo-traction in the treatment of refractory cervical kyphosis secondary to infections has never been reported. This study investigated the role of halo-traction in the treatment of cervical infection patients associated with refractory kyphosis. We retrospectively reviewed 48 patients with cervical infection associated with refractory kyphosis who were treated in our spine department. Patients were divided into two groups, the traction group (A) and the non-traction group (B). Group A underwent preoperative halo-traction followed by surgery, while group B underwent surgery alone. Between the two groups, we analyzed the kyphosis deformity correction, level of fusions, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), functional improvement by Neck disability index (NDI) score, and complications. Group A had a better correction of kyphosis deformity compared to group B (27.01 ± 11.54)0 versus (18.08 ± 10.04)0 (P = 0.01, Z =  − 2.44). No statistically significant differences between the two groups in terms of functional improvement, level of fusions, ESR and CRP. Group B had 3 revision surgery cases. Preoperative halo-traction followed by surgery is superior in kyphosis correction in the treatment of patients with cervical infections with refractory kyphosis.
CAR-tropic extracellular vesicles carry tumor-associated antigens and modulate CAR T cell functionality
Authors: Ukrainskaya V. M. , Musatova O. E. , Volkov D. V. , Osipova D. S. , Pershin D. S. , Moysenovich A. M. , Evtushenko E. G. , Kulakovskaya E. A. , Maksimov E. G. , Zhang H. , Rubtsov Y. P. , Maschan M. A. , Stepanov A. V. , Gabibov A. G.
Published: January 2023

Tumor-derived extracellular vesicles (EVs) are active contributors in metastasis and immunosuppression in tumor microenvironment. At least some of the EVs carry tumor surface molecules such as tumor-associated antigens (TAAs) and/or checkpoint inhibitors, and potentially could interact with T cells or CAR T cells. Upon contact with T cells, EVs could alter their phenotype and functions by triggering signaling through TCR or CAR reprogramming them to escape immune response. We hypothesize that EVs that possess TAA on the surface will probably interact with CAR T cells which can recognize and bind corresponding TAA. This interaction between EVs and CAR T cells may change the outcome of CAR T-based cancer immunotherapy since it should affect CAR T cells. Also, EVs could serve as adjuvants and antigenic components of antitumor vaccines. Herein, we isolated EVs from B cell precursor leukemia cell line (pre-B ALL) Nalm-6 and demonstrated that recognition and binding of CD19+EVs with CD19-CAR T cells strongly depends on the presence of CD19 antigen. CD19+EVs induce secretion of pro-inflammatory cytokines (IL-2 and IFN-y) and upregulated transcription of activation-related genes (IFNG, IFNGR1, FASLG, IL2) in CD19-CAR T cells. Tumor necrosis factor receptor superfamily (TNFRSF4 and TNFRSF9) and T-cell exhaustion markers (CTLA4, LAG3, TIM3 and PDCD1LG2) were also upregulated in CD19-CAR T cells after incubation with CD19+EVs. Long-term cultivation of CD19+ or PD-L1+EVs with CD19-CAR T cells led to increased terminal differentiation and functional exhaustion according to elevated expression of PD-1, TIGIT, CD57. In summary, our results suggest that chronic exposure of CD19-CAR T cells to CD19+EVs mediates activation and systemic exhaustion in antigen-specific manner, and this negative effect is accompanied by the impaired cytotoxic activity in vitro.
A strategy for evaluating potential antiviral resistance to small molecule drugs and application to SARS-CoV-2
Authors: Sargsyan Karen , Mazmanian Karine , Lim Carmay
Published: January 2023

Alterations in viral fitness cannot be inferred from only mutagenesis studies of an isolated viral protein. To-date, no systematic analysis has been performed to identify mutations that improve virus fitness and reduce drug efficacy. We present a generic strategy to evaluate which viral mutations might diminish drug efficacy and applied it to assess how SARS-CoV-2 evolution may affect the efficacy of current approved/candidate small-molecule antivirals for Mpro, PLpro, and RdRp. For each drug target, we determined the drug-interacting virus residues from available structures and the selection pressure of the virus residues from the SARS-CoV-2 genomes. This enabled the identification of promising drug target regions and small-molecule antivirals that the virus can develop resistance. Our strategy of utilizing sequence and structural information from genomic sequence and protein structure databanks can rapidly assess the fitness of any emerging virus variants and can aid antiviral drug design for future pathogens.
Mechanism of cystogenesis by Cd79a-driven, conditional mTOR activation in developing mouse nephrons
Authors: Tran Nguyen Truc Linh , Matsuda Satoshi , Takenouchi Akiko , Tran Thuy Huong Quynh , Kotani Yui , Miyazaki Tatsuhiko , Kanda Hiroaki , Yoshizawa Katsuhiko , Tsukaguchi Hiroyasu
Published: January 2023

Polycystic kidney disease (PKD) is a common genetic disorder arising from developmental and postnatal processes. Defects in primary cilia and their signaling (eg, mTOR) underlie the pathogenesis. However, how mTOR regulates tubular integrity remains unclear. The paucity of faithful models has limited our understanding of pathogenesis and, therefore, the refinement of therapeutic targets. To understand the role of mTOR in early cystogenesis, we studied an in-house mouse model, Cd79a-Cre;Tsc1ff. (Cd79a-Tsc1 KO hereafter), recapitulating human autosomal-dominant PKD histology. Cre-mediated Tsc1 depletion driven by the promoter for Cd79a, a known B-cell receptor, activated mTORC1 exclusively along the distal nephron from embryonic day 16 onward. Cysts appeared in the distal nephron at 1 weeks of age and mice developed definite PKD by 4 weeks. Cd79a-Tsc1 KO tubule cells proliferated at a rate comparable to controls after birth but continued to divide even after postnatal day 14 when tubulogenesis is normally completed. Apoptosis occurred only after 9 weeks. During postnatal days 7–11, pre-cystic Cd79a-Tsc1 KO tubule cells showed cilia elongation, aberrant cell intercalation, and mitotic division, suggesting that defective cell planar polarity (PCP) may underlie cystogenesis. mTORC1 was activated in a portion of cyst-lining cells and occasionally even when Tsc1 was not depleted, implying a non-autonomous mechanism. Our results indicate that mTORC1 overactivation in developing distal tubules impairs their postnatal narrowing by disrupting morphogenesis, which orients an actively proliferating cell toward the elongating axis. The interplay between mTOR and cilium signaling, which coordinate cell proliferation with PCP, may be essential for cystogenesis.
Detailed morphological structure and phylogenetic relationships of Degeeriella punctifer (Phthiraptera: Philopteridae), a parasite of the bearded vulture Gypaetus barbatus (Accipitriformes: Accipitridae)
Authors: Pérez Jesús M. , Sáez-Ventura Ángeles , Liébanas Gracia , Rossi Luca , Fernández Mercedes , Fraija-Fernández Natalia
Published: January 2023

Habitat loss is one of the main threats to species survival and, in the case of parasites, it is their hosts that provide their habitat. Therefore, extinction even at local scale of host taxa also implies the extinction of their parasites in a process known as co-extinction. This is the case of the bearded vulture (Gypaetus barbatus), which almost became extinct at the beginning of the twentieth century. After several attempts, this species was successfully reintroduced into the Alps at the end of the twentieth century. We collected 25 lice specimens from an electrocuted bearded vulture from Susa (Italian Alps) that were morphologically identified asDegeeriella punctifer. Six individuals were studied by scanning electron microscopy, with particular emphasis on their cephalic sensorial structures, while four further specimens were characterized at molecular level by amplifying partial regions of the12SrRNA,COX1and elongation factor 1 alpha (EF-1) genes. From a morphological perspective, the number, type and arrangement of the sensillae on the two distal antennal segments is quite similar to that of other species of the family Philopteridae (Phthiraptera: Ischnocera). The mandibles and tarsal claws allow lice to cling firmly to their host’s feathers. Phylogenetic analyses help unravel the paraphyletic nature of the genusDegeeriellaand demonstrate the clear differentiation between lice parasitizing Accipitriformes and Falconiformes, as well as the close relationship betweenD. punctifer, D. fulva, D. nisusandCapraiellasp. that, along with other genera, parasitize rollers (Aves: Coraciiformes).
Evolution of field induced magnetic phase attributed to higher order magnetic moments in TbVO4
Authors: Ranaut Dheeraj , Mukherjee K.
Published: January 2023

Study of quantum magnetism in rare earth orthovanadates (RVO4, R = rare earth) is a topic which is currently being investigated by the condensed matter physicists. In this work, through both experimental and theoretical tools, we report the presence of field induced magnetic phase, attributed to fifth order susceptibility, in TbVO4, at low temperatures. The structural transition reported around 31 K, results in the formation of pseudospin—$${\raise0.7ex\hbox{$1$} \!\mathord{\left/ {\vphantom {1 2}}\right.\kern-0pt} \!\lower0.7ex\hbox{$2$}}$$

1

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2

doublet ground state separated by an energy δ. Temperature dependent heat capacity indicates toward an increment in δ, on application of magnetic fields. Above 10 kOe, the Zeeman energy associated with magnetic anisotropy strengthens, resulting in an enhanced splitting of the pseudo-doublet ground state. This increased splitting stabilizes the magnetic phase associated with higher order moments. These observations are further supported by our theoretical model to evaluate δ, as a function of applied field. Our study provides a platform to study the possible presence of higher order moments in other Jahn–Teller systems.
Preparation of Au-RGO/TiO2 nanotubes and study on the photocatalytic degradation of ciprofloxacin
Authors: Zuo Jinlong , Ma Xuewei , Tan Chong , Xia Zhi , Zhang Yingting , Yu Shiyou , Li Yiwen , Li Yuanyuan , Li Junsheng
Published: January 2023

Au-RGO/TiO2 nanotubes were prepared by anodic oxidation and electrochemical deposition, and their performance for photocatalytic degradation of ciprofloxacin was investigated.
A dual-emission ratiometric fluorescent sensor based on copper nanoclusters encapsulated in zeolitic imidazolate framework-90 for rapid detection and imaging of adenosine triphosphate
Authors: Xin Yue , Zhang Dun , Zeng Yan , Wang Yingwen , Qi Peng
Published: January 2023

A dual-emission ratiometric fluorescent sensor Cu NCs–Al@ZIF-90 was synthesized for ATP detection. The fluorescence emission of Cu NCs and 2-ICA induced by ATP addition was changed reversely and independently.
A boronate-affinity magnetic molecularly imprinted polymer for luteolin recognition
Authors: Ding Li-xin , Wang Yong-qiang , Sun Xue , Jiang Zhao-qi , Wang Xiao-yu , Zhou Yan-fen , Hou Xing-yu
Published: January 2023

A novel boronate-affinity molecularly imprinted solid-phase extraction adsorbent is reported for the selective enrichment of luteolin.
Manganese Prussian blue nanozymes with antioxidant capacity prevent acetaminophen-induced acute liver injury
Authors: Chen Chongqing , Wu Haitao , Li Qianhui , Liu Menghua , Yin Fan , Wu Miaomiao , Wei Xiaoli , Wang Hua , Zha Zhengbao , Wang Fei
Published: January 2023

Manganese Prussian blue nanoparticles (MPBZs), bioactive antidotes for APAP poisoning, efficacious against APAP-induced liver injury (AILI) by inhibiting oxidative stress, suppressing hepatocyte apoptosis, and reducing inflammation.
Targeted photothermal release of antibiotics by a graphene nanoribbon-based supramolecular glycomaterial
Authors: Shang Ying , Zhang Sheng , Gan Hui-Qi , Yan Kai-Cheng , Xu Fugui , Mai Yiyong , Chen Daijie , Hu Xi-Le , Zou Lei , James Tony D. , He Xiao-Peng
Published: January 2023

A supramolecular glycomaterial has been developed using the self-assembly of pyrenyl glycosides and graphene nanoribbon-based nanowires for the targeted, photothermally-controlled release of antibiotics to bacteria.
Nanoscale domain imaging of Li-rich disordered rocksalt-type cathode materials with X-ray spectroscopic ptychography
Authors: Uematsu Hideshi , Ishiguro Nozomu , Abe Masaki , Takazawa Shuntaro , Kang Jungmin , Konuma Itsuki , Yabuuchi Naoaki , Takahashi Yukio
Published: January 2023

Domain structure in Li-rich disordered rocksalt-type cathode particles is visualized using X-ray spectroscopic ptychography and clustering analysis.
The structure of protic ionic liquids based on sulfuric acid, doped with excess of sulfuric acid or with water
Authors: McGrogan Anne , Byrne Emily L. , Guiney Robert , Headen Thomas F. , Youngs Tristan G. A. , Chrobok Anna , Holbrey John D. , Swadźba-Kwaśny Małgorzata
Published: January 2023

Sulfuric acid-based protic ionic liquids (PILs) incorporate water into their hydrogen-bonded anionic chains via strong hydrogen bonds. These water-doped PILs form a new water-in-ionic liquid solvent system, with distinct structure and properties.
The role of single-atom Rh-dopants in the adsorption properties of OH and CO on stepped Ag(211) surfaces
Authors: Neto Marionir M. C. B. , Verga Lucas G. , Da Silva Juarez L. F. , Galvão Breno R. L.
Published: January 2023

We explore how the adsorption of OH and CO are affected by the presence of isolated Rh atoms on stepped Ag surfaces.
The pure spin current and fully spin-polarized current induced by the photogalvanic effect and spin-Seebeck effect in halogen-decorated phosphorene
Authors: Zheng Zibin , Zhu Lin , Cao Zenglin , Guo Xiaohui , Wang Yin , Yao Kailun
Published: January 2023

A device based on halogen-decorated phosphorene can behave multifunctionally, where a pure spin photocurrent and a fully spin-polarized photocurrent can be effectively controlled by the incident light and the temperature gradient.
Metallic bonds and thermal vibration in brass
Authors: Yokoyama Toshihiko
Published: January 2023

The thermal vibrational amplitude around Zn is found to be meaningfully smaller than Cu. The peculiar finding is interpreted as a result of confinement of Zn in a smaller space and a significantly larger repulsive potential of Zn than Cu.
Effect of MoSe2 nanoribbons with NW30 edge reconstructions on the electronic and catalytic properties by strain engineering
Authors: Gao Nan , Yang Xiaowei , Chen Jinghuang , Chen Xinru , Li Jiadong , Fan Junyu
Published: January 2023

MoSe2 nanoribbons with NW30 edge reconstructions increase the dynamic stability and catalytic activity by DFT investigation.
Microwell array chip-based single-cell analysis
Authors: Zhang Jin , Xue Jing , Luo Ningfeng , Chen Feng , Chen Badong , Zhao Yongxi
Published: January 2023

This review summarizes microwell array chip-based single-cell analysis of versatile biomolecules including nucleic acids, proteins and metabolites.
Virtual-freezing fluorescence imaging flow cytometry with 5-aminolevulinic acid stimulation and antibody labeling for detecting all forms of circulating tumor cells
Authors: Matsumura Hiroki , Shen Larina Tzu-Wei , Isozaki Akihiro , Mikami Hideharu , Yuan Dan , Miura Taichi , Kondo Yuto , Mori Tomoko , Kusumoto Yoshika , Nishikawa Masako , Yasumoto Atsushi , Ueda Aya , Bando Hiroko , Hara Hisato , Liu Yuhong , Deng Yunjie , Sonoshita Masahiro , Yatomi Yutaka , Goda Keisuke , Matsusaka Satoshi
Published: January 2023

Heterogeneous clusters of cancer cells and leukocytes in blood were visualized by combining high-throughput and high-sensitivity fluorescence imaging flow cytometry with 5-aminolevulinic acid stimulation.
Binary solvent engineering for small-molecular organic semiconductor crystallization
Authors: He Zhengran , Zhang Ziyang , Asare-Yeboah Kyeiwaa , Bi Sheng
Published: January 2023

This article reviews the synergistic effects of engineering binary solvents on the crystallization, morphology and charge transport of organic semiconductors.
Tuning oxygen-containing functional groups of graphene for supercapacitors with high stability
Authors: Lin Shiqi , Tang Jie , Zhang Kun , Chen Youhu , Gao Runsheng , Yin Hang , Qin Lu-Chang
Published: January 2023

This study aims to investigate the relationship between the residual functional groups on graphene sheets and the stability of graphene supercapacitors, thereby improving the performance of graphene supercapacitors.
Synthesis of SiO2@MnCo2O4 core–shell nanorattles using layered double hydroxide precursors and studies on their peroxidase-like activity
Authors: Rana Pankaj , Jeevanandam Pethaiyan
Published: January 2023

The current work demonstrates a simple soft chemical approach to synthesize SiO2@MnCo2O4 core–shell nanorattles using SiO2@MnCo-LDH (layered double hydroxide) precursors.
Adsorption-enhanced rapid catalytic degradation of ofloxacin by a CoS2@montmorillonite catalystviaperoxymonosulfate activation
Authors: Hong Peiping , Wu Lian , Zhao Yifang , Yu Yue , Gao Shuxi , Liao Bing , Pang Hao
Published: January 2023

With the combination of absorption capability and catalytic activity, the CoS2@MMT exhibited the potential as the AOP catalyst to degrade ofloxacin rapidly and effectively.
Biomolecules incorporated in halide perovskite nanocrystals: synthesis, optical properties, and applications
Authors: Aminzare Masoud , Jiang Jennifer , Mandl Gabrielle A. , Mahshid Sara , Capobianco John A. , Dorval Courchesne Noémie-Manuelle
Published: January 2023

Biomolecules have been integrated in halide perovskite nanocrystals (HPNCs), impacting their formation, physicochemical properties, and stability. We address the biomolecule's role in modulating HPNCs properties and extending their applications.
Metal-free synthesis of dihydrofuran derivatives as anti-vicinal amino alcohol isosteres
Authors: Nangunuri Bhargav Gupta , Shirke Rajendra P. , Kim Mi-hyun
Published: January 2023

Dihydrofuran cores are commonly incorporated into synthetically and pharmacologically significant scaffolds in natural product and drug discovery chemistry.
Self-recovery of chiral microphase separation in an achiral diblock copolymer system
Authors: Miao Tengfei , Cheng Xiaoxiao , Zhang Gong , Wang Yuqing , He Zixiang , Wang Zhao , Zhang Wei
Published: January 2023

A chirality-storing copolymer MPS structure will overcome the external chiral source dependence and avoid tedious synthesis and expensive raw materials.
Three-component reductive conjugate addition/aldol tandem reaction enabled by nickel/photoredox dual catalysis
Authors: Zhao Hongping , Yuan Weiming
Published: January 2023

A three-component reductive cross-coupling of aryl halides, aldehydes, and alkenes by nickel/photoredox dual catalysis is reported. The key to success for this tandem transformation is to identify α-silylamine as a unique organic reductant.
Light-driven redox deracemization of indolines and tetrahydroquinolines using a photocatalyst coupled with chiral phosphoric acid
Authors: Chen Qipeng , Zhu Yuanli , Shi Xujing , Huang Renfu , Jiang Chuang , Zhang Kun , Liu Guohua
Published: January 2023

A light-driven redox deracemization to prepare optically pure cyclamines from their racemates is developed. This reaction provides a wide range of chiral indolines and tetrahydroquinolines with high yields and enantioselectivities.
Vertically π-extended strong acceptor unit boosting near-infrared photothermal conversion of conjugated polymers toward highly efficient solar-driven water evaporation
Authors: Li Hua-Chun , Li Hao-Nan , Zou Ling-Yun , Li Qian , Chen Peng-Fei , Quan Xiu-Ni , Deng Ke , Sheng Chun-Qi , Ji Jian , Fan Quli , Xu Zhi-Kang , Wan Jun-Hua
Published: January 2023

A donor–acceptor polymer with broad absorption from 300 to 1700 nm as a photothermal material toward highly efficient solar-driven water evaporation.
Orbital hybridization states of carbon functionalize the alkali-ion storage capability of hard carbons
Authors: Yang Ying , Huang Chenli , Zhao Ruirui , Gao Zhonghui , Qi Xiaoqun , Zhang Wang , Lu Xing , Qie Long , Huang Yunhui
Published: January 2023

A series of “pure” hard carbon models, built using C60 as precursor, help to correlate the alkali-ion (e.g., Li+, Na+, and K+) storage behaviour of hard carbons to orbital hybridization states of carbon atoms.
Highly selective semiconductor photocatalysis for CO2 reduction
Authors: Yao Shan , He Jiaqing , Gao Feng , Wang Haowei , Lin Jiahui , Bai Yang , Fang Jingyun , Zhu Feng , Huang Feng , Wang Mengye
Published: January 2023

Herein, to provide ideas for the design of highly selective CO2 reduction materials, we introduce each step of the photocatalytic CO2 reduction process and summarize how each step is adjusted to promote the selectivity of CO2 reduction.
An Interactive and Neurodiversity-Affirming Approach to Communication Supports for Autistic Students Through Videogaming
Authors: Santhanam Siva priya
Published: January 2023

Purpose:

Videogaming offers an interactive, enjoyable, and socially valid context for interaction between autistic and non-autistic students in schools. In this tutorial, I describe an approach that supports communication and peer interaction through group-based videogaming. This approach creates an opportunity for autistic and non-autistic students to engage in a meaningful and enjoyable activity and to promote acceptance and appreciation of communication differences.

Method:

This tutorial includes development, planning, essential components, goal writing, and a list of resources and directions to implement the videogaming-based group intervention in middle and high school settings. This tutorial is grounded in a supports-based, anti-ableist, neurodiversity framework that embraces a difference-based view of autistic communication. Cost-effectiveness and ease of implementation make this intervention feasible for school settings.

Conclusions:

Ableist practices are pervasive in academic and clinical settings. There is an urgency within the field of speech-language pathology to address misconceptions regarding autism and autistic individuals, increase the understanding and appreciation of diversity in autistic communication, and eliminate practices that may promote autistic masking. These can be achieved by developing supports that value the preferences and experiences of autistic individuals and honor their strengths. Videogaming is one context that supports social communication. It does not hinge upon normative communication as a benchmark. Increased contact and exposure to autistic peers through fun and engaging game-based interactions help reduce stigma and prejudice toward autistic students.
Teacher Questioning to Promote Extended Language Use for Preschool Emergent Bilinguals
Authors: Buckley Laura , Mancilla-Martinez Jeannette , Ozdemir Merve
Published: January 2023

Purpose:

Emergent bilinguals (EBs) from Spanish-speaking households are a sizable and quickly growing segment of the preschool population in the United States. However, there is limited research on the provision of opportunities for EBs to engage in language-rich classroom discussion, particularly in English-dominant contexts where most EBs attend preschool. This study focused on teacher and Spanish–English EBs' language interactions in an English-dominant preschool program to better understand whether and, if so, how teachers' use of questioning strategies provided extended oral language use opportunities for Spanish-speaking EBs in their classrooms.

Method:

We adopted a sequential–explanatory mixed-methods design to examine audio recordings from whole-group instruction across seven preschool classrooms and investigate how EBs responded to teachers' conversationally responsive questioning strategies, with a specific focus on how they used Spanish as they composed extended responses. Researchers coded 31 audio recordings from 12 EB students to identify teachers' (
n
= 7) use of questioning strategies (closed-response, open-response, and single-word-response), as well as students' responses to questions (one-word-response or extended response) and Spanish use.

Results:

Teachers' use of closed-response and single-word-response questions emerged as most important in supporting Spanish–English EBs' extended language use during whole-group instruction. Furthermore, the majority of student responses that included Spanish utterances were extended responses, underscoring the value of Spanish use for students to develop extended responses.

Conclusion:

Findings suggest that equitable opportunities to enter into classroom dialogue for EBs might require more explicitly scaffolded questioning strategies and might necessitate the purposeful and intentional use of Spanish.
Reducing carbon emissions and energy costs in multi‐building facilities: A Co‐optimisation approach
Authors: Abbas Akintonde , Chowdhury Badrul
Published: January 2023

Commercial buildings remain one of the most significant consumers of energy. As such, any sustainable pathway to a zero‐emissions future will need to pay close attention to emissions reduction in commercial buildings. An interesting category of commercial buildings is the multi‐building commercial facility with different buildings collocated within a defined geographical area, serving different purposes and containing varying equipment types. While most existing facility management approaches focus on minimising energy costs and emissions at the level of each building, this work considers a different perspective where energy and emissions are co‐optimised across all buildings within the facility. Illustrative case studies based on a multi‐building facility consisting of individual buildings adapted from the United States Department of Energy's (DOE) Commercial Reference Buildings database are considered. Different diurnal and seasonal variations in building usage are also considered. Simulations are run using a Python‐based commercial building simulation toolbox. Results indicate that the co‐optimisation approach can indeed provide superlinear emissions reductions and energy cost savings while satisfying predefined comfort limits compared to when each building is separately optimised.
A 2022τ-Herculid meteor cluster from an airborne experiment: automated detection, characterization, and consequences for meteoroids
Authors: Vaubaillon J. , Loir C. , Ciocan C. , Kandeepan M. , Millet M. , Cassagne A. , Lacassagne L. , Da Fonseca P. , Zander F. , Buttsworth D. , Loehle S. , Toth J. , Gray S. , Moingeon A. , Rambaux N.
Published: January 2023

Context. The existence of meteor clusters has long since been a subject of speculation and so far only seven events have been reported, among which two involve less than five meteors, and three were seen during the Leonid storms.

Aims. The 1995 outburst of Comet 73P/Schwassmann-Wachmann was predicted to result in a meteor shower in May 2022. We detected the shower, proved this to be the result of this outburst, and detected another meteor cluster during the same observation mission.

Methods. Theτ-Herculids meteor shower outburst on 31 May 2022 was continuously monitored for 4 h during an airborne campaign. The video data were analyzed using a recently developed computer-vision processing chain for meteor real-time detection.

Results. We report and characterize the detection of a meteor cluster involving 38 fragments, detected at 06:48 UT for a total duration of 11.3 s. The derived cumulative size frequency distribution index is relatively shallow:s= 3.1. Our open-source computer-vision processing chain (named FMDT) detects 100% of the meteors that a human eye is able to detect in the video. Classical automated motion detection assuming a static camera was not suitable for the stabilized camera setup because of residual motion.

Conclusions. From all reported meteor clusters, we crudely estimate their occurrence to be less than one per million observed meteors. Low heliocentric distance enhances the probability of such meteoroid self-disruption in the interplanetary space.
Offset between X-ray and optical centers in clusters of galaxies: Connecting eROSITA data with simulations
Authors: Seppi R. , Comparat J. , Nandra K. , Dolag K. , Biffi V. , Bulbul E. , Liu A. , Ghirardini V. , Ider-Chitham J.
Published: January 2023

Context.The characterization of the dynamical state of galaxy clusters is key to studying their evolution, evaluating their selection, and using them as a cosmological probe. In this context, the offsets between different definitions of the center have been used to estimate the cluster disturbance.

Aims.Our goal is to study the distribution of the offset between the X-ray and optical centers in clusters of galaxies. We study the offset for clusters detected by the extended ROentgen Survey with an Imaging Telescope Array (eROSITA) on board the Spectrum-Roentgen-Gamma (SRG) observatory. We aim to connect observations to predictions by hydrodynamical simulations andN-body models. We assess the astrophysical effects affecting the displacements.

Methods.We measured the offset for clusters observed in the eROSITA Final Equatorial-Depth Survey (eFEDS) and the first eROSITA all-sky survey (eRASS1). We focus on a subsample of 87 massive eFEDS clusters at low redshift, withM500c> 1×1014 M⊙and 0.15 <z< 0.4. We compared the displacements in such sample to those predicted by the TNG and the Magneticum simulations. We additionally link the observations to the offset parameterXoffmeasured for dark matter halos inN-body simulations, using the hydrodynamical simulations as a bridge.

Results.We find that, on average, the eFEDS clusters show a smaller offset compared to eRASS1 because the latter contains a larger fraction of massive and disturbed structures. We measured an average offset of ΔX−O = 76.3−27.1+30.1kpc, when focusing on the subsample of 87 eFEDS clusters. This is in agreement with the predictions from TNG and Magneticum, and the distribution ofXofffrom dark matter only (DMO) simulations. However, the tails of the distributions are different. Using ΔX − Oto classify relaxed and disturbed clusters, we measured a relaxed fraction of 31% in the eFEDS subsample. Finally, we found a correlation between the offset measured on hydrodynamical simulations andXoffmeasured on their parent dark-matter-only run and we calibrated the relation between them.

Conclusions.We conclude that there is good agreement between the offsets measured in eROSITA data and the predictions from simulations. Baryonic effects cause a decrement (increment) in the low (high) offset regime compared to theXoffdistribution from dark matter-only simulations. The offset–Xoffrelation provides an accurate prediction of the trueXoffdistribution in Magneticum and TNG. It allows for the offsets to be introduced in a cosmological context with a new method in order to marginalize over selection effects related to the cluster dynamical state.
Visions contrastées des services écosystémiques des zones humides saisonnières du Gharb, Maroc
Authors: Choukrani Hajar , Kuper Marcel , Hammani Ali , Lacombe Guillaume , Taky Abdelilah
Published: January 2023

Immergés en hiver, les marais saisonniers (merjas) de la plaine du Gharb au Maroc étaient traditionnellement exploités pour le pâturage en été, à côté d’autres usages productifs. Pourtant, ils étaient considérés par l’administration coloniale comme des milieux insalubres et peu valorisés, malgré leur abondance en ressources naturelles. Au cours du XXe siècle, la plaine a fait l’objet d’un aménagement hydro-agricole, incorporant les merjas, pour contribuer aux objectifs nationaux de sécurité alimentaire et d’exportation de produits agricoles. Cet article interroge le regard porté par les acteurs locaux et institutionnels sur les merjas et les bénéfices qu’elles procurent, à travers une analyse des services écosystémiques. Si les institutions les considèrent comme des terres vierges à aménager et des zones tampon de régulation des crues pour protéger les secteurs aménagés et les villes, les collectivités riveraines les considèrent comme des espaces productifs, défavorisés par les crues. L’étude montre des visions contrastées des services écosystémiques, où chaque acteur a une vision utilitariste des merjas. Malgré le débat international sur la biodiversité et le stockage de carbone dans les zones humides, les dimensions écologiques sont peu citées. L’approche par les services écosystémiques dévoile les antagonismes entre acteurs, mais peut être un moyen de négociation sur le devenir des merjas dans une vision territoriale.
Measuring film: A visual exploration of cinema under the wave of digital humanities
Authors: Wang Hong
Published: January 2023

Searching the relevant literature analysis in the CNKI database, it is found that the research boom of quantitative film science in the domestic academic community has been heating up year by year in recent years. Quantitative empirical research is integrated into the research of film ontology, which really finds a new path for the domestic film research academic community. According to Barry Salt, the director's personal style can be expressed in the external form of the film. Taking the inland China film “Spring Tide” and the Taiwan film “ Little Big Women” as examples, the quantitative film thinking combined with narrative theory as a reference frame is used to conduct quantitative empirical research on the text of family ethics films in the same period between inland China and China Taiwan.
Research on the impact mechanism of major public health emergency on China's economic growth
Authors: Zheng Fang , Yu Xiaowen
Published: January 2023

Under different transmission mechanisms, major public health emergencies have different effects on economic growth. Based on the specific economic impact of COVID-19, a literature analysis method was used to systematically explain the economic impact of different channels and specific transmission mechanisms caused by major public health emergencies. Major public health emergencies caused serious damage to life and health, and had a huge impact on the entire economic environment. However, different economic sectors have different levels and channels of impact from the pandemic. The existing literature has analysed the various impact mechanisms of major public health emergencies on the economic development process from many angles, but there are still problems that need in-depth discussion and supplementary research.
Research on university teaching in Metaverse era from the perspective of interactive ritual chain
Authors: Kong Cui
Published: January 2023

According to the development of Metaverse, its outstanding features and the logical relationship of Metaverse empowerment education, this paper uses the interactive ritual chain theory to explore that the arrival of Metaverse will bring new changes to link in the ritual chain of new educational symbols, “presence” in teaching, boundaries and barriers, ways of sharing emotional experience, etc. Therefore, this study mainly discusses the chain interactive logic of college teaching situation setting from the perspective of Metaverse, and then provides some ideas of teaching changes in university under the Metaverse era.
Research on the influence, causes and countermeasures of college students' mobile phone dependence
Authors: Xu Peihong , Chen Liang , Jiang Ziyi , Tao Rong , Chen Qiying
Published: January 2023

Based on the rapid development of Internet technology and the popularity of mobile phone use, there are more problems caused by college students' mobile phone use. This paper analyzes the influence of College Students' mobile phone dependence from two aspects, and states the causes of this phenomenon from both subjective and objective aspects. Finally, it gives the Countermeasures of College Students' mobile phone dependence from five aspects, in order to enable college students to reasonably control the time of using mobile phones, Use mobile phones scientifically.