bluuebunny/crossref_metadata_2025 huggingface dataset:
RENDEMEN DAN KUALITAS MINYAK KAYU PUTIH (Melaleuca cajuputi) DARI PENYULINGAN PT INHUTANI II PULAU LAUT
Authors: Rahmah Aprilia , Sari Noor Mirad , Ulfah Diana
Published: November 2022

The yield and quality of cajuput oil refined by PT Inhutani II aims to determine the yield and quality of the distillation of cajuput oil (Melaleuca cajuputi). This research was conducted in Semaras Village, Pulau Laut Barat District, Kotabaru Regency. The time required to carry out this research is three months including observation, distillation process and data processing for the preparation of research. The leaves used in this study were 2 tons, where the distillation was carried out 2 times with one distillation using 1 ton of dry cajuput leaves. The method used is steam and water for 6-7 hours. Data processing includes calculating yield and testing the quality of oil samples sent to the laboratory with a total of six parameters including, among others, cineol content with GC and visual color using the 2014 SNI quality standard. The first yield is 1.13%, the second is 1.01%. The quality of cajuputi oil from the distillation of PT Inhutani II Pulau Laut has met the SNI requirements with the results of the first distillation quality being color, pale yellow and brown, specific gravity 0.9186 0.9171, refractive index 1.4630, 1.4553, optical rotation -0-50 °- 0.90 °, the solubility in alcohol 80% is 1:1 and the cineol content is 78.51% and 71.03%Rendemen dan kualitas minyak kayu putih dari penyulingan PT Inhutani II bertujuan untuk mengetahui hasil rendemen dan kualitas dari penyulingan daun minyak kayu putih (Melaleuca cajuputi). Penelitian ini dilaksanakan di Desa Semaras Kecamatan Pulau Laut Barat Kabupaten Kotabaru. Waktu yang diperlukan dalam pelaksanaan penelitian ini tiga bulan yaitu kegiatan observasi, proses menyuling serta pengolahan hasil data untuk penyusunan penelitian. Daun yang digunakan dalam penelitian ini sebanyak 2 ton, dimana penyulingan dilakukan sebanyak 2 kali dengan satu kali penyulingan menggunakan 1 ton daun kayu putih kering. Metode yang digunakan adalah uap dan air selama 6-7 jam. Pengolahan data meliputi perhitungan rendemen dan pengujian kualitas sampel minyak yang dikirim pada Laboratorium sejumlah enam parameter mencakup antara lain yaitu kadar sineol dengan GC dan warna secara visual dengan menggunakan standar mutu SNI 2014. Hasil rendemen penyulingan pertama sebesar 1,13% sedangkan yang kedua sebesar 1,01%. Rendemen pertama sebesar 1,13%, kedua sebesar 1,01%. Kualitas minyak kayu putih hasil dari penyulingan PT Inhutani II Pulau Laut telah memenuhi syarat SNI dengan hasil kualitas penyulingan pertama yaitu warna, berwarna kuning pucat dan coklat, berat jenis 0,9186, 0,9171, indeks biasnya sebesar 1,4630, 1,4553, putaran optik -0-50°, -0,90°, kelarutan dalam alkohol 80% yaitu 1:1 serta kadar sineol 78,51% dan 71,03%.
KINERJA PENYULUH KEHUTANAN DI KESATUAN PENGELOLAAN HUTAN (KPH) TANAH LAUT
Authors: Asrifa Astri Belinda Nur , Asysyifa Asysyifa , Hafizianor Hafizianor
Published: November 2022

The aims of this research was to analyze the level of foresty intructor performance in KPH Tanah Laut and to analyze the factors that affect the level of foresty intructor performance in KPH Tanah Laut. The research method used is saturation sampling method. Saturation sampling method is the sampling method with entire population. The data was collected by interview and distributing questionnaires as primary data and secondary data of information from journals, report or data from related intitute. The result showed that the performence of forestry intructor in KPH Tanah Laut based on an assessment of 7 criteria (Employee Administration, The Condition of Working Area, The Planning, The Forestry Conseling Activity, Result and Impact of the Forestry Conseling Activity, Monitoring, Evaluation and Reporting, and Development Activities of the Supporting Profession) overall got a “good” level of performance with score of 60,45. Meanwhile, for each respondent such as respondent 1, the performance level was "enough" with a score of 57.88, respondent 2 received a "good" performance level with a score of 67.24 and respondent 3 received a performance level "enough” with a value of 56.24. The factors that influence the level of performance of the forestry instructor in the Tanah Laut KPH are age, education and competence, motivation and independence, and the scope of the forestry instructor's work areaPenelitian ini bertujuan menganalisis tingkat kinerja penyuluh kehutanan di KPH Tanah Laut dan menganalisis faktor-faktor apa saja yang mempengaruhi tingkat kinerja penyuluh kehutanan di KPH Tanah Laut. Metode penelitian menggunakan metode sampling jenuh. Metode sampling jenuh adalah metode pengambilan sampel dengan seluruh populasi. Pengumpulan data dilakukan dengan wawancara dan pembagian kuesoner sebagai data primer dan data sekunder berupa informasi dari jurnal, laporan, atau data dari instansi terkait. Hasil penelitian menunjukkan kinerja penyuluh kehutanan di KPH Tanah Laut berdasarkan penilaian dari 7 kriteria (Administrasi Kepegawaian, Kondisi Wilayah Kerja/Binaan, Perencanaan, Kegiatan Penyuluhan, Hasil dan Dampak Kegiatan Penyuluhan, Pemantauan, Evaluasi Dan Pelaporan, dan Kegiatan  Pengembangan Profesi Penunjang) secara keseluruhan mendapat tingkat kinerja “bagus” dengan nilai 60,45. Sedangkan untuk masing-masing responden seperti responden 1 mendapat tingkat kinerja “cukup” dengan nilai 57,88, responden 2 mendapat tingkat kinerja “bagus” dengan nilai 67,24 dan responden 3 mendapat tingkat kinerja “cukup” dengan nilai 56,24. Faktor-faktor yang mempengaruhi tingkat kinerja penyuluh kehutanan di KPH Tanah Laut yaitu usia, pendidikan dan kompetensi, motivasi dan kemandirian, serta cangkupan wilayah kerja penyuluh kehutanan.
BIODIESEL FROM PALM OIL WITH INTERESTERIFICATION PROCESS USING BIO-CATALYST CAJUPUT OIL
Authors: Daryono Elvianto Dwi , Dewi Rini Kartika
Published: November 2022

Proses interesterifikasi yang telah dilakukan menggunakan katalis homogen maupun heterogen yang perlu proses pemisahan di akhir reaksi. Minyak atsiri merupakan alternatif pilihan katalis yang lebih efisien sebab tidak perlu proses pemisahan di akhir reaksi karena berfungsi sebagai antioksidan untuk biodiesel dan lebih ramah lingkungan. Tujuan penelitian adalah untuk mendapatkan proses pembuatan biodiesel yang lebih efektif dan efisien yaitu dengan tahapan proses yang lebih sedikit sehingga akan mengurangi biaya produksi. Pada penelitian ini reaksi interesterifikasi minyak kelapa sawit dengan metil asetat untuk menghasilkan metil ester dan triasetin, dilakukan dengan bio-katalis  minyak kayu putih. Kondisi operasi penelitian adalah massa minyak kelapa sawit 250 gram, rasio molar minyak kelapa sawit:metil asetat adalah 1:6, suhu reaksi 60oC, kecepatan pengadukan 300 rpm, massa katalis 0,75% massa minyak kelapa sawit dan waktu reaksi (15, 30, 45, 60, dan 75 menit). Minyak kelapa sawit, metil asetat dan katalis direaksikan dalam labu leher tiga sebagai reaktor sesuai dengan kondisi operasi penelitian. Setelah waktu reaksi tercapai, sample sebanyak 50 gram diambil untuk dilakukan proses pemisahan. Hasil penelitian mendapatkan kondisi terbaik proses interesterifikasi minyak kelapa sawit dengan bio-katalis minyak kayu putih pada waktu reaksi 75 menit dengan crude yield 65,88% dan angka asam 0,426 mg KOH/gr sampel yang memenuhi SNI 7182:2015.
ABSORBER DESIGN SIMULATION FOR CO2 USING K2CO3 ABSORBENT WITH ASPEN HYSYS V.10 SOFTWARE
Authors: Chotimah Chusnul , Syafitri Naja Nikmah , Udyani Kartika
Published: November 2022

An absorber is a tool used in the absorption process to separate a certain gas component from a gas mixture using a chemical solution as an absorbent. This simulation aimed to determine the effects of the packing type and column diameter on flooding, the packing type and column diameter on pressure drop, and the gas flow rate on CO2 removal. It also investigated the best absorber design based on %flooding and pressure drop. This simulation was carried out using the Aspen Hysys software version V.10. The variables of packing type consisted of PALL, berl, and raschig. The simulation results indicated that the larger the column diameter for each type of packing, the smaller the %flooding value. Meanwhile, the limit value of the %flooding for each type of packing given by Aspen Hysys was 30%– 80%. Further simulation results showed that the larger the column diameter in each type of packing, the smaller the pressure drop value. The pressure drop limit value given by Aspen Hysys was 3,658 mbar. In addition, the next simulation results demonstrated that the greater the value of the given gas flow rate, the greater the % CO2 removal value. Thus, the effective absorber design viewed from the %flooding and pressure drop was a 0.5-inch berl dimension with ceramic material. Keywords: absorber, type of packing, flooding, pressure drop, CO2 removai
DIFFUSION OF CIVIC ENGAGEMENT LITERATURE WEBSITE INNOVATION FOR SMART AND PARTICIPATORY VILLAGE COMMUNITIES
Authors: Batubara Abdinur
Published: November 2022

DIFFUSION OF CIVIC ENGAGEMENT LITERATURE WEBSITE INNOVATION FOR SMART AND PARTICIPATORY VILLAGE COMMUNITIES ABTRACTThis research was conducted to develop a digital-based literacy innovation in an effort to form participatory village citizen engagement literacy. The method used is a qualitative method and a realist ethnographic research design. The population is the people of Tumpatan village, Beringin sub-district, Deli Serdang regency and the sample is people aged 17-36 years. The data analysis used is the Miles and Hubermann model data analysis. Based on the research results obtained, it shows that the existence of a civic engagement literacy website developed by the research team has a positive impact on the Tumpatan village community so that their daily activities in the village support the realization of a participatory village. So that the website project is empowered by the village community to explore their various activities in the fields of politics, education, social, religion, art, etc.Keywords: Civic Engagement, Educational innovation, and citizen participation.
Upaya Guru PPKn Meningkatkan Pemahaman Peserta Didik Tentang Bhinneka Tunggal Ikan di SMAN 1 Kec.Lareh Sago Halaban
Authors: Yuhasnil Yuhasnil , Kurnia Ade , Wati Mulia Kusuma
Published: November 2022

Latar belakang penelitian ini, yaitu guru PPKn, diharapkan akan melahirkan anak didik yang memiliki cakrawala pandangan luas, menghargai perbedaan, penuh toleransi, dan penghargaan terhadap segala bentuk perbedaan dalam pemahaman Bhinneka Tunggal Ika  seperti kebersamaan, kerukunan, dan keadilan harus bisa diinternalisasikan dengan baik kepada peserta didik supaya tercermin dalam kehidupannya sehari-hari. Penelitian ini bertujuan untuk mendeskripsikan upaya guru PPKn dalam meningkatkan pemahaman peserta didik  tentang Bhinneka Tunggal Ika di SMA N 1 Kecamatan Lareh Sago Halaban Kabupaten Lima Puluh kota.Jenis penelitian ini adalah kualitatif dengan menggunakan metode deskriptif, teknik pengumpulan data yang digunakan adalah Obsevasi, wawancara mendalam, Studi pustaka dan Dokumentasi. Informan penelitian ditentukan secara purposive sampling. Untuk menjamin keabsahan data dilakukan dengan teknik triangulasi dan  analisis data dengan menggunakan langkah- langkah reduksi data, penyajian data dan yang terakhir penarikan kesimpulan.Hasil penelitian menunjukan Upaya guru PPKn dalam meningkatkan pemhaaman mengenai Bhinneka Tunggal Ika yaitu dengan meningkatkan pemahaman melalui  pembelajaran  di kelas dan juga melalui pembelajaran bimbingan belajar SMAN 1 Kec. Lareh Sago Halaban  dan adapun kendala yang di hadapi guru PPKn dalam memberikan materi Bhinneka Tunggal Ika yaitu kurangnya sarana dan prasarana pendukung pembelajaran  dan kurangnya minat peserta didik dalam pembelajaran PPKn.
KESULTANAN BANJAR SEBAGAI ASET PARIWISATA: KREDIBILITAS SUMBER INFORMASI UNTUK MEMBANGUN PEMAHAMAN MASYARAKAT KABUPATEN BANJAR
Authors: Chandrabuwono Achmad Bayu , Alif Muhammad
Published: November 2022

Kredibilitas komunikator menjadi penentu efektifitas komunikasi agar pesan dapat diterima oleh komunikan. pada gilirannya akan menentukan efektivitas sosialisasi nilai dalam membangun pemahaman masyarakat bahwa Kesultanan Banjar sebagai asset wisata budaya dan menggerakkan atau merubah sikap khalayak untuk memelihara warisan budaya tersebut. Kredibilitas sumber informasi berkaitan dengan kinerja komunikator untuk memberikan pemahaman tentang Kesultanan Banjar sebagai Aset Pariwisata menurut pandangan masyarakat di Kabupaten Banjar. Alo Liliweri, (2003) Kredibilitas biasanya yang dilihat , kewenangan dan kompetensi , Karakter , karisma diri. Selain itu (Shimp, 2010) mengatakan ada dua sifat penting dari kredibilitas sebagai pendukung adalah yang pertama Keahlian , Kepercayaan.Metode yang digunakan adalah metode kualitatif. Hasil penelitian menunjukkan kredibilitas komunikator dalam membangun pemahaman  tentang  Kesultanan Banjar sebagai aset Wisata Budaya di Kabupaten Banjar  Kalimantan Selatan sudah termasuk dalam kategori kredibel.
A RELAÇÃO GESTOR-SUBORDINADOS À LUZ DA PSICODINÂMICA DO TRABALHO
Authors: Evaristo Jorge Luiz de Souza , Batista-dos-Santos Ana Cristina , Araújo Andressa Aguiar , Rocha Ana Raquel Silva
Published: November 2022

O objetivo dessa pesquisa é compreender a relação gestor-subordinado à luz da Psicodinâmica do Trabalho, em instituições públicas, em tempos de flexibilidade. A revisão de literatura abrange os precedentes e características gerais da Nova Gestão Pública. Metodologicamente, empreendeu-se uma pesquisa qualitativa. Para coleta de dados, utilizou-se entrevistas narrativas com gestores e subordinados, adotando-se a técnica de análise dos núcleos de sentido com o auxílio do software Atlas.ti para compreensão das narrativas. Após a transcrição e categorização das entrevistas emergiram três temas: relações de trabalho, prazer-sofrimento e reconhecimento. Da análise e discussão dos resultados foi possível identificar que os entrevistados apresentam uma postura defensiva quando suscitado temas associados a conflito e adoecimento, sugerindo a existência de uma estratégia defensiva coletiva de negação do sofrimento. Ademais, o reconhecimento é tratado como algo subentendido, de modo que os entrevistados demonstram dificuldades ao tratar do assunto.
Galactic Symmetry
Authors: Oldani Richard
Published: November 2022

Differences between the quantum mechanical and relativistic concepts of time are explained by applying the strong equivalence principle to the electron in an atomic clock. The resulting clock model calls for the microscopic equations of motion of the electron to be formulated in Minkowski space, and for the photon to be described relativistically as a four-dimensional localization of energy. The resulting Lagrangian formulation of quantum mechanics is completely analogous to the more familiar nonrelativistic Hamiltonian model based on the Schrödinger equation. It accounts for the 720 degree rotation of a wave function as the absorption of one 360 degree electromagnetic wave cycle and the emission of another, yielding two wave cycles to correspond with one clock cycle. Because the properties of energy are universal the equations are able to be extended to include galaxies in spite of vast differences in lifetime. They show that symmetry exists between the electromagnetic fields of atoms and the gravitational fields of galaxies due to the presence in both of radial and transverse fields. The description of galaxy structure is fundamentally distinct because it is based on the conjugate variables energy and time.
Cyber Security Threats to Educational Institutes: A Growing Concern for the New Era of Cybersecurity
Authors: Jawaid Syed Adnan
Published: November 2022

Background: The outbreak of the Covid-19 pandemic has significantly affected the operations of higher education institutions. Due to the limited use of video conferencing and cloud computing in these facilities, distance learning became the only option available to them. Objective: The study focused on identifying the most common types of attacks that can affect e-learning assets. Results: There was a lack of clear cybersecurity policies for educational institutes and universities in 2020, according to a report by Microsoft Security Intelligence. The report showed that the education industry was the most targeted sector for malware attacks in the last 30 days. Conclusion: The recommendations for improving the security of e-learning systems. Some of these include implementing policies that restrict access to the resources and applications, updating security patches, and using cryptographic protocols.
Osmanlı Son Dönemi Ulemasından Cemil Molla’ya Göre Siyasal Yönetim Biçimleri ve II. Abdülhamid Yönetimi
Authors: EYİGÜN Melek , ÖZKAN Selim Hilmi
Published: November 2022

Cemil Molla, Osmanlı Devleti’nde 17. yüzyıldan itibaren ilmiye sınıfının çeşitli üst kademelerinde görev yapmış bir ulema ailesi olan Üryanizâdelerin son temsilcilerinden biri olarak Osmanlı bürokrasisinde çeşitli görevler almıştır. Ulema ailesinin geleneksel eğitim anlayışı çerçevesinde İslâmî ilimleri tahsil ettikten sonra müspet ilimlerde, özellikle hukuk alanında söz sahibi olabilecek kadar eğitim alma fırsatı bulmuştur. Cemil Molla’nın daha önce basılmamış Dağarcığım adıyla bilinen hatıratı bu çalışmanın ana kaynağıdır. Bu çalışmada, hatırattan yola çıkılarak padişaha ve saraya yakınlığı ile tanınan Osmanlı’nın son dönem ulemasından Cemil Molla’nın siyasal yönetim biçimlerine ve II. Abdülhamid iktidarına yönelik fikirlerinin yansıtılması amaçlanmıştır. Ayrıca söz konusu döneme tanıklık etmiş aydın ve bürokratların yönetim anlayışları ve bu konudaki temel iddialarına değinilmiştir. Dönemin mutlakiyet ve meşrutiyet yönetim biçimlerine dair tartışmaları çerçevesinde Cemil Molla’nın zihin dünyasına ışık tutulmaya çalışılmıştır. Konu ile ilgili araştırma eserleri ve makalelerin yanı sıra biyografi kaynaklarından, vakanüvis tarihlerinden, Aile Özel Arşivi’nden, Cumhurbaşkanlığı Devlet Arşivleri ve İstanbul Müftülüğü Şer’iyye Sicilleri Arşivi’nden istifade edilmiştir.
Presentismo y trastornos músculo esqueléticos en las enfermeras del Instituto Nacional de Salud del Niño de Breña 2020
Authors:   , Valdiviezo Salazar Lourdes Maribel , Campos Landeo Janet
Published: November 2022

Actualmente, las actividades laborales de las enfermeras son repetitivas, constantes y abrumadoras de 12 horas continuas, por ese motivo se encuentran en riesgo de sufrir diversos trastornos músculo esqueléticos y asistir a laborar con dolencias. Objetivo: determinar la relación entre presentismo y trastornos músculo esqueléticos en las enfermeras del Instituto Nacional de Salud del Niño (INSN) de Breña 2020. Materiales y métodos: La presente investigación fue elaborada utilizando un enfoque cuantitativo, correlacional, de diseño no experimental, y con corte transversal. La muestra fue obtenida mediante técnica de muestreo aleatorio por racimo, cuyo número fue 87 enfermeras. Para evaluar las variables se utilizaron como instrumentos el cuestionario Nórdico de Kuorinka (alfa de Cronbach 0,85) y la Escala Stanford versión española (mayor a 0,70) respectivamente; se cumplió con los criterios de rigor científico y principios éticos Resultados: La población estudiada fue 100% de sexo femenino, principalmente entre 30 y 40 años (36,8%), de estado civil casadas (44,8%), con 1 o 2 hijos (57.5%). Se identificó los trastornos músculo esqueléticos, siendo el más frecuente en el área cuello (43.3%), dorsal o lumbar (29.8%), hombro (12.5%) y presentismo en enfermería (54%). El resultado de estas dos variables evidencia una relación de significancia (p=0,002) entre presentismo y trastornos músculo esqueléticos Conclusión: se concluye que, existe una relación entre presentismo y trastornos músculo esqueléticos, lo cual pone en riesgo la calidad de la atención de las enfermeras.
Costos de servicio y rentabilidad en una agencia de relaciones públicas, distrito de San Isidro (Lima-Perú), 2020
Authors:   , Rivero Palacios Eduardo Leonard
Published: November 2022

El presente trabajo de investigación tuvo como objetivo general determinar la relación entre los costos de servicio y rentabilidad en una agencia de relaciones públicas, distrito de San Isidro (Lima-Perú), 2020. Como la empresa es prestadora de servicio, uno de sus recursos más importantes es el capital humano, por lo que es necesario que se mantenga el buen desempeño de dicho personal al prestar los servicios, ya que esto incide directamente en la rentabilidad de la misma. La investigación se realizó bajo un diseño no experimental, de tipo descriptivo correlacional y transversal, con un enfoque cuantitativo. La población objeto de estudio estuvo conformada por los trabajadores de la agencia de relaciones públicas, en total 36 trabajadores, y la muestra fue por conveniencia, un total de 12 personas. Para recopilar los datos, se implementó un cuestionario de 22 preguntas cerradas, con escala de Likert. Se obtuvo como resultado que los costos de servicio inciden de forma negativa y moderada sobre la rentabilidad, debido a que mientras más altos son dichos costos, menor es la rentabilidad. Se recomienda a la agencia publicitaria mantener el control de sus costos de servicio a través de un sistema de costos por servicio, y de igual forma mantener actualizados sus procesos contables en materia de costos por servicios para evitar información que carezca de fidelidad.
Health-related quality of life and family well-being in pediatric patients with genetic conditions and their families: a scoping review protocol
Authors: Smith Hadley Stevens , Hanmer Janel
Published: November 2022

Background: Genetic conditions can have a substantial impact on the health and well-being of children and their family members and caregivers. However, little is known about how health-related quality of life and family well-being compare across various pediatric genetic conditions and the instruments used to measure these constructs.
Methods: The proposed scoping review of the literature will follow standard methodological guidance for scoping reviews, including the six-stage framework developed by Arksey & O’Malley. We use the Arksey & O’Malley framework to structure the review protocol, which adheres to preferred reporting items for systematic review and meta-analysis protocols reporting systematic review protocols (PRISMA-P) reporting standards with modifications as appropriate for scoping reviews. We will systematically search PubMed and EMBASE for original, peer-reviewed research articles published after January 1, 2010 that report primary data on: 1) pediatric health-related quality of life for patients with genetic conditions; 2) health-related quality of life in family members and caregivers of pediatric patients with genetic conditions; 3) family well-being in families affected by pediatric genetic conditions. We will summarize the genetic conditions studied and the instruments used to assess health-related quality of life and well-being.
Discussion: The proposed scoping review will provide an overview of the state of the literature on health-related quality of life in pediatric patients affected by genetic conditions and their family members and caregivers. Findings will inform research study design, clinical care, and future research needs.
Systematic review registration: This review is prospectively registered on the Open Science Framework (https://osf.io/sxk8u/).
Rehabilitation in Survivors of COVID-19 (RE2SCUE): a non-randomized, controlled and open study
Authors: Campos Maria Cristine , Nery Tatyana , Speck Ana Elisa , Arpini Maiqueli , Antunes Moisés Moraes , Alves Ana Cristina de Bem , Santos Naiara de Souza , Matos Maria Paula Pereira , Junior Nelson Schmidt , Bicca Letícia Roehe , Panisson Camila Mascarelo , Freitas Mariana Alves , Diefenthaeler Fernando , Kuriki Heloyse Uliam , Damin Vanessa , Rosa Rodrigo Oliveira Da , Gress Josiane Bueno , Schneider Ione Jayce Ceola , Vieira Danielle Soares Rocha , Arcêncio Livia , Aguiar Aderbal S
Published: November 2022

The sequelae of coronavirus disease-2019 (COVID-19) are another socio-economic problem of the pandemic. Fatigue and dyspnea are the most prevalent symptoms. It is not known whether exercise can be used to treat long COVID-19. This study aimed to investigate the effects of an 8-week face-to-face rehabilitation program on COVID-19 compared to a remote monitoring group. A total of 37 participants (24.3% hospitalized) were assessed before and after rehabilitation (n = 22; 40.8 ± 10.0 years) or remote monitoring (n = 15; 45.4 ± 10.5 years). The participants were allocated according to their preferences. Both groups showed improved fatigue and exercise capacity (Incremental Shuttle Walk Test). Participants in the face-to-face rehabilitation group showed improved dyspnea (Pulmonary Functional Status and Dyspnea Questionnaire), anxiety (Hospital Anxiety and Depression Scale), attention, and short-term memory (d2-R and Rey's Auditory-Verbal Learning Test). Of the main sequelae, fatigue improves naturally, whereas dyspnea requires rehabilitation. Our results demonstrated the benefits of exercise for COVID-19 sequelae.
Anatomical and functional outcomes after bilateral sacrospinous colposuspension (BSC) for the treatment of female genital prolapse
Authors: Hosni Wael , Schmidt Carl-Michael , Ludwig Sebastian , Mallmann Peter
Published: November 2022

Background
Pelvic organ prolapse is a bothersome condition affecting many women at advanced age, but also frequently observed in young women with certain risk factors. Various surgical techniques have been developed with the aim of providing effective surgical treatment for apical prolapse. The vaginal bilateral sacrospinous colposuspension surgery with BSC-mesh and utilization of the i- stich is a relatively new minimal invasive technique with very promising outcomes. The technique offers apical suspension, in the presence or absence of the uterus. The objective of this study is to evaluate the anatomical and functional outcomes of bilateral sacrospinous colposuspension (BSC) in 30 Patients treated with the vaginal single incision standardized technique.
Methods
In this retrospective study, 30 patients were treated by BSC for significant vaginal, uterovaginal or cervical prolapse. A simultaneous anterior colporrhaphy, posterior colporrhaphy or both were performed when indicated. Anatomical and functional outcomes were assessed 1 year postoperatively using the pelvic organ prolapse quantification system (POP-Q) and the standardised Perceived Quality of Life (P-QOL) questionnair.
Results
The POP-Q parameters were significantly improved at twelve months after surgery compared to baseline. The total score and all four subdomains of the P-QOL-questionnaire showed positive trends and improvement at twelve months after surgery when compared to preoperative values. All patients were asymptomatic and expressed high satisfaction one year after surgery. No intraoperative adverse events were recorded for all patients. Only minimal postoperative complicatations were recorded and they all resolved completely with conservative management.
Conclusion
This study highlights the functional and anatomical outcomes of the minimally invasive bilateral sacrospinal colposuspension for the management of apical prolapse. The BSC procedure can produce excellent outcomes with minimal complications. The data published here are very promising and warrant further investigations and more studies to evaluate the long-term outcomes of BSC in the surgical management of apical defects.
Trial registration:
The study protocol was approved by the Ethics Committee at the University Hospital of Cologne, Germany (Date of registration: 08.02.2022) (Registration number: 21-1494-retro) (retrospectively registered).
Incidence of QTc interval prolongation in patients treated for covid-19 with Doubase C or Hydroxychloroquine-azithromycin at University Hospital of Kinshasa
Authors: Madioko Brady Makanzu , Rissassi Jean-Robert Makulo , Mihigo Constantin Bashengezi , Kurhenga Gilbert Kabanda , Mwilambwe Benjamin Kabue , Kasago Freddy Mugisho , Mufungizi Jeancy Ngaboyeka , Khonde Stanilsas Nsasi , Ezabika Christian Bashengezi , Okwé Augustin Ngé , Longo-Mbenza Benjamin
Published: November 2022

Background: QTc prolongation has been described in COVID-19 patients treated with Hydroxychloroquine (HCQ) and Azithromycin (AZT) in western countries. In the Democratic Republic of the Congo (DRC), few studies have assessed the safety of these molecules, and neither have they for new molecules proposed for COVID-19 treatment, such as Doubase C. This study aimed to determine the incidence of QTc prolongation in COVID-19 patients treated with HCQ-AZT or Doubase C.
Methods: This study was part of a randomized clinical trial. Data were collected from May 20, 2021, to January 15, 2022. Patients were randomized into two arms; one was treated with Doubase C and the other with HCQ-AZT at standard dosages. Only patients with mild to moderate COVID-19 were included.
Results: A total of 261 patients were included. At inclusion, the two groups were comparable (52.5% men, 47.5% women, mean age 41±15 years. The incidence of prolonged QTc interval was 1.5% in the whole group (3.3% on the HCQ-AZT arm and 0% on the Doubase C arm). No ventricular arrhythmias or torsade de pointes, or cardiac arrest were observed.
Conclusion: Unlike Doubase C, the HCQ-AZT strategy has a risk of QTc prolongation.
Knockout of formyl peptide receptor 1 reduces osteogenesis and bone healing
Authors: Yang Xinlin , Xiao Wan'an , Le Quang , Lee Sang-Hyun , Dighe Abhijit , Kerrigan Jason R , Cui Quanjun
Published: November 2022

Background
Formyl peptide receptor 1 (FPR1), a key member of Formyl peptide receptors (FPRs) from a G-protein coupled receptor family, was previously well-characterized in immune cells. But the function of FPR1 in osteogenesis and fracture healing was rarely reported. In this study, using the FPR1 knockout (KO) mouse, for the first time, we demonstrated a close correlation of FPR1 function to osteogenic differentiation of bone marrow-derived stem cells (BMSCs) in vitro and bone fracture healing in vivo.
Methods
Primary BMSCs were isolated from both FPR1 KO and wild type (WT) mice. Osteogenic markers were detected during osteogenic differentiation of BMSCs. Biomechanical and structural properties of femur were compared between healthy WT and KO mice by mechanical test and microcomputed tomographic. A closed, transverse fracture at the femoral midshaft was created to compare bone healing between KO and WT mice.
Results
The FPR1 mRNA level increased significantly during osteogenesis of BMSCs. More importantly, compared to BMSCs from FPR1 KO mice, WT BMSCs expressed significantly higher levels of common osteogenic markers as well as mineralization at day 14 and 21. In addition, the femur from WT mice had better biomechanical and structural properties than the femur from FPR1 KO mice. Furthermore, at day 35 following femur fracture, bone healing in WT mice was remarkably improved compared to FPR1 KO mice, demonstrated by X-ray appearance, H&E stain, bone density, and bone volume/total volume.
Conclusion
FPR1 plays an important role in osteogenic differentiation, bone mechanical strength, and regenerative capacity of fractured bone. Knockout of FPR1 reduces osteogenesis and bone healing in vivo and vitro.
Direct enantioselective allylation of nitriles to NH2-α-tertiary amines
Authors: Li Qing , Shi Yinrui , Li Jiuling , Guo Yafei , Fan Baomin
Published: November 2022

Organic molecules, containing one or more amine chiral centers, are pretty common to see in natural products and medicines. Although a large number of methods have been developed to afford enantiopure amines, most of the known approaches are limited with various reasons. For example, many methodologies start from nitrogen protected and activated substrates, which usually need multistep operations and seriously decrease the atom economy. Here we disclose a new catalytic three-component strategy from commercial nitriles directly to high enantioselective a-tertiary primary amines in up to 90% yield and 95% enantiomeric excess. This transformation firstly undergoes an addition process of organolithium reagents to nitrile to generate the imine intermediate in situ. Subsequently, the most challenging step is by employing copper catalytic enantioselective addition of AllylBpin to the lithium imine intermediate to form the final amine in one pot.
Deep-trap Dominated Degradation of the Endurance Characteristics in OFET memory with Polymer Charge-Trapping Layer
Authors: Yu Tianpeng , Liu Zhenliang , Wang Yiru , Zhang Lunqiang , Hou Shuyi , Wan Zuteng , Yin Jiang , Gao Xu , Wu Lei , Xia Yidong , Liu Zhiguo
Published: November 2022

Organic field-effect transistors (OFETs) with polymer charge-trapping dielectric, which exhibit many advantages over Si-based memory devices such as low cost, light weight, and flexibility, still suffer challenges in practical application due to the unsatisfied endurance characteristics and even the lack of fundamental of behind mechanism. Here, we real that the degradation of endurance characteristics of pentacene OFET with poly(2-vinyl naphthalene) (PVN) as charge-storage layer is dominated by the deep hole-traps in PVN by using the photo-stimulated charge de-trapping technique with the fiber-coupled monochromatic-light probes. The depth distribution of hole-traps in PVN film of pentacene OFET is also provided.
Comparison of recommendations from cirrhosis Clinical Practice Guidelines and from Cochrane systematic reviews
Authors: Roberts Danielle , Leung Jeffrey , Gluud Christian , Nikolova Dimitrinka , Pavlov Chavdar , Davidson Brian , Gurusamy Kurinchi
Published: November 2022

Background: Clinical practice guidelines (CPGs) contain recommendations intended to aid clinicians in providing optimal care for patients and should be derived from the best quality evidence available. The highest quality evidence is obtained through systematic reviews using Cochrane methodology. This exploratory study aimed to determine the proportion of guideline statements from major liver organisations in USA and Europe that were consistent with the conclusions of recent systematic reviews using Cochrane methodology.
Methods: We selected four topics related to decompensated cirrhosis on which our group has recently published Cochrane systematic reviews (variceal bleeding; spontaneous bacterial peritonitis; ascites; hepatorenal syndrome). We performed a purposive sample of CPGs from leading organisations covering these topics: American Association for the Study of Liver Diseases (AASLD); British Society of Gastroenterology (BSG); European Association for the Study of the Liver (EASL); and National Institute for Health and Care Excellence (NICE) until January 2022. For each guideline recommendation statement, two researchers independently assessed whether there was agreement in the statement and the strength of recommendation given by guideline authors when compared to those derived from the Cochrane reviews. We meta-analysed the proportion of agreement using ‘meta’ package for R utilising the ‘Generalised Linear Mixed Model’ method for meta-analysis of proportions.
Results: We identified 9 CPGs containing 62 guideline statements that were also covered in 7 Cochrane reviews. Agreement between the guideline authors and independent assessment was 0.145 (95% CI: 0.077 to 0.256), i.e., there was disagreement in 85.5% of recommendation statements. There was disagreement on four of the 62 guideline statements about the use or consideration of an intervention when there was no evidence to support their use or consideration. The remaining disagreements related to the disagreement in the strength of recommendation: in each of these disagreements, the guideline author had provided a strong recommendation for or against an intervention when there was only weak evidence for or against the intervention. For each disagreement in the strength of recommendation, the strength of recommendation was overstated rather than understated by the guideline authors. The disagreement could not be explained by the difference in the search dates between the guidelines and Cochrane reviews.
Conclusion: The strength of recommendation given in the majority of CPGs from leading liver organisations on decompensated liver cirrhosis did not match those derived from Cochrane reviews. Our findings suggest a systematic issue with guideline developers overstating the strength of recommendations, which has the potential for direct impact on patient care.
External and limited internal fixation in the treatment of open Gustilo-Anderson Grade III ankle fractures: A single-center retrospective cohort study
Authors: Zheng Lei , MU Weidong , Xu Peng
Published: November 2022

Background
The treatment of Gustilo-Anderson grade III open distal tibia fractures remains controversial, and often results in serious complications, including amputation. External fixation combined with limited internal fixation (EFLIF) can provide stability and exert beneficial effects on the fracture. This study evaluated the functional and clinical outcomes of EFLIF in patients with Gustilo-Anderson grade III open distal tibia fractures.
Methods
We retrospectively reviewed the clinical and follow-up data of 36 patients with open distal tibia fracture treated in our hospital between January 2017 and July 2021. We excluded cases lost to follow-up and those who underwent amputation. The data analysis included 26 patients with Gustilo-Anderson grade III fractures. The patients were followed up for traumatic surface recovery, ankle complications, and ankle function. The American Orthopedic Foot & Ankle score (AOFAS) was used to evaluate the functional outcomes.
Results
The 26 patients were followed up for 6–24 (mean, 14) months. Based on the AOFAS, the outcome in 17 patients was excellent, good in five, medium in three, and poor in one. No patient experienced incision breakdown, postoperative infection, or fracture nonunion.
Conclusion
The EFLIF can achieve positive outcomes when used to treat open distal tibia fractures. Sometimes, it can be considered the first line of treatment for open distal tibia fractures.
Sex-Specific Disruption in Human Placental miRNAs and mRNAs Involved in IUGR Placental Insufficiency and Capillary Angiogenesis
Authors: Song Wenhui , Guo Qing , Puttabyatappa Muraly , Elangovan Venkateswaran Ramamoorthi , Wang Jianping , Li Fang , Liu Fangfang , Bi Xuejie , Li Haiying , Fu Guangping , Padmanabhan Vasantha , Wu XiaoHua
Published: November 2022

Intrauterine growth restriction (IUGR) is one of the most common pregnancy complications culminating in adverse fetal outcome, including preterm birth, neonatal mortality and stillbirth. Compromised placental development and function, especially disruption in angiogenesis and inadequate nutrient supply are contributing factors. Fetal sex also influences placental function. Knowledge of gene expression changes and epigenetic factors contributing to placental dysfunction in IUGR pregnancies will help identify biomarkers and help target interventions. This study tested the hypothesis that IUGR pregnancies are associated with sexually-dimorphic disruptions in miRNA - an epigenetic factor and mRNAs invloving key mediators of angiogenesis and microvessel development. Changes in expression of key genes/proteins involved in placental dysfunction by RT-PCR and immunohistochemistry and miRNA changes by RNA sequencing were undertaken with term placenta from 12 control and 20 IUGR pregnancies. Findings showed sex-dependent changes in expression of genes involved in steroidogenesis, steroid action, IGF family members, inflammatory cytokines and angiogenic factors in IUGR pregnancies. In addition, upregulation of MIR451A and downregulation of MIR543 in placentas from IUGR group with female newborns and upregulation of MIR520G in placentas from IUGR group with male newborns were also noted. MIR451A and MIR543 have been implicated in angiogenesis. Consistent with gene changes, CD34, the microvessel angiogenesis marker, also showed reduced staining only in female IUGR group. These findings provide evidence in support of sexual dimorphism in the capillary development of IUGR manifested at the level of key mediators of placental angiogenesis and placental function that include changes in expression of miRNA with potential to serve as biomarkers.
Safety and efficacy of atosiban: a systematic review and a meta-analysis of randomized controlled trials and observational studies
Authors: Zhang Yi , Feng Xin
Published: November 2022

Background: Atosiban has shown ameliorative effects in preterm birth (PTB), repeated implantation failure, and breech delivery by suppressing contractions, but its safety profile has not been fully established.
Methods: Published randomized controlled trials and observational studies was electronically searched from inception to September 1, 2022. Our primary outcomes were maternal adverse events and neonatal comorbidities. Random effects model was used for data synthesis, and pooled risk ratios (RRs) with corresponding 95% confidence intervals (CIs) were calculated.
Results: 43 studies comprising 11,772 patients were identified eligible. The incidence of maternal adverse events in atosiban group and controls were 4.0% and 12.4%, respectively. Overall, the risk of maternal adverse events and the discontinuation of treatment due to adverse events were significantly lower with atosiban compared with controls (RR 0.38, 95% CI [0.23, 0.61], P < 0.0001; RR 0.11, 95% CI [0.04, 0.29], P < 0.00001; respectively). The incidence of neonatal comorbidities was similar, and a higher risk of neonatal apnoea was observed in atosiban group compared with controls (RR 1.40, 95% CI [1.04, 1.90], P = 0.03).
Conclusion: Atosiban has comparable efficacy and substantial better safety profile in the management of PTB, in vitro fertilization-embryo transfer (IVF-ET) and external cephalic version (ECV) compared with controls. Additionally, awareness of the presence of neonatal apnoea is required. In clinical practice, the appropriate treatment regimen needs to be selected according to the local circumstances and the individual patient condition.
Supplementation of carbohydrate enzymes plus protease to the diet of finishing pigs containing 2 protein levels on the effects of growth performance, toxic gas emissions, meat quality, and colonic microbiota community
Authors: Zhang Qianqian , Cho Sungbo , Song Junho , Jeong Jinuk , Yu Minjae , Mun Seyoung , Han Kyudong , Kim Inho
Published: November 2022

Background Dietary supplementation with exogenous enzymes may positively affect the traits of finishing pigs. The present study investigated the effects of different protein levels and exogenous carbohydrate enzymes plus protease on growth performance, meat quality, toxic gas emissions, and the structure and function of colonic microbiota in finishing pigs.
The correlation between bank risk, performance, and regulatory capital for Conventional banks in golf cooperation countries
Authors: BENALI Wissem , mhamid imen
Published: November 2022

This article aims at illustrating the link between the bank risk, regulatory capital, and the bank performance. By using a panel dynamic data in the GMM estimator on a large dataset of 73 banks belonging to Golf Cooperation Countries from 2000 to 2018, we have discovered that both the regulatory capital and the bank performance have a negative association with bank risk. Thus, we have analyzed the link between the bank risk and the bank performance on regulatory capital and discovered that the bank risk negatively influences the bank performance. However, with banks with larger capital ratios the bank performance improves noticeably. Finally, we finished by demonstrating the impact of the financial crisis on these relationships, and our robustness check confirms our major findings.
What is the Impact of Vitamin D Levels on COVID-19 Severity?: A Systematic Review
Authors: Kersh Lydia , Geary Kyla , Roberts Michael , Daghigh Farzaneh
Published: November 2022

Keywords:
Vitamin D, Covid-19
BACKGROUND
COVID-19, a novel virus, was first discovered in 2019. It is a respiratory disease caused by SARS-CoV-2. It has been suspected that vitamin D levels play an important role in the immune response to respiratory illnesses causing the attenuation of infection. Considering this, vitamin D levels have also been found to have a similar effect on patients infected with COVID-19.
Application and Research of Basketball Footwork Supported by Intelligent Edge Cloud Computing and Deep Learning Unsupervised Transfer Method
Authors: Sun Hui , Gao Meng
Published: November 2022

Basketball is a comprehensive physical sport in which footwork migration is the key point. To explore the current teaching status of basketball footwork mobile, Deep Learning (DL) and unsupervised transfer methods are combined to extract the footwork movement characteristics of basketball players for data analysis and research. At the same time, to effectively analyze the feature data of the collected player footwork, intelligent edge cloud computing is used to carry out advanced processing on the extracted data features, and Convolutional Neural Networks (CNNs) are employed to perform transfer learning on the extracted target domain samples. Feature extraction is performed on the data, and the impending action of a basketball player is predicted. Meanwhile, the unsupervised human action transfer method is studied to provide new ideas for basketball footwork action series data modeling. Finally, the theoretical framework based on intelligent edge cloud computing and DL unsupervised transfer method is summarized. Its principle is explored and applied in the teaching of basketball footwork. The results show that: (1) The converged convolutional network and classification network parameters can predict players’ movement trajectories. (2) Compared with the existing supervised learning methods on synthetic datasets, unsupervised training using network data dramatically increases the variety of actions during training. (3) The classification accuracy of the transfer learning method is high, and it can be used for the different basketball footwork in the corresponding stage of the court.
Suitability evaluation of land reclamation as arable land in coal mining area based on catastrophe theory
Authors: Li Yinghui
Published: November 2022

A catastrophe progression model for the suitability evaluation of land reclamation as arable land in coal mining area was put forward based on the catastrophe theory. The suitability classification of land reclamation as arable land in coal mining area was divided into four grades: suitable, moderately suitable, less suitable, and unsuitable. On the basis of comprehensive consideration of three factors including land quality, soil nutrients and engineering suitability in the reclamation area, eleven parameters including terrain slope grade, effective thickness of soil layer, soil parent materials, soil contamination, organic content, alkali hydrolyzable nitrogen (N), available phosphorus (P), available potassium (K), ground collapse, land destruction extent, and conditions of irrigation and drainage were selected as evaluation indicators, and the classification standards of each evaluation indicator was determined. Using MATLAB software to generate 800 total samples (200 samples per level) between the arrays corresponding to each level of standards according to the principle of normal distribution, of which 600 were used as training samples to establish the catastrophe progression criteria, and 200 were used as test samples to verify the reliability of the proposed criteria, and the proposed criteria also were verified by engineering examples. The suitability of land reclamation as arable land in coal mining area in Shaodong county, China, was comprehensively evaluated by using the proposed model. The research results have reference and guiding significance for the comprehensive evaluation of the suitability of land reclamation as arable land in coal mining areas.