bluuebunny/crossref_metadata_2025 huggingface dataset:
Early diagnosis and management of finish type congenital nephrotic syndrome in a 3-year-old child: A case report
Authors: Tanzeel Ur Rahman  , Noman Salih  , Momal Irshad  , Israr Hussain  , Nabila Bibi  , Shad Muhammad Khan  , Waris Rafiq
Published: April 2024

This study describes a 3-year-old non Finnish girl who was diagnosed with Finnish-type nephrotic syndrome (FTNS), a rare kidney illness brought on by NPHS1 gene abnormalities. Even though she had low protein levels and severe swelling when she was three months old, her case of congenital nephrotic syndrome (CNS) was incorrectly identified as minimal change disease (MCD). The standard MCD treatments, cyclosporine and steroids, did not affect her. A genetic test and a kidney sample confirmed the diagnosis of FTNS, a condition that necessitates an early renal transplant for survival. She is awaiting a kidney transplant and was treated with drugs that save proteins to lessen her edema. The study emphasizes the significance of FTNS early and correct diagnosis as well as the requirement for alternate treatments for this difficult illness.
Pelizaeus disease Merzbacher like: About an observation
Authors: F. ETIENE IRINEU  , H. LACHRAF  , H. RHOUDA  , G. ZOUIRI  , S. MOUSSAOUI  , H. LAJI  , H. TALBAOUI  , S. DAHRI  , L. CHABRAOUI  , Y. KRIOUILE
Published: April 2024

Pelizaeus-Merzbacher disease (PM) is an X-linked leukodystrophy causing developmental delay, nystagmus, hypotonia, spasticity and variable intellectual deficit. Three forms are described according to age of onset and severity: neonatal forms (+ severe), classical form (moderate, first 2 months of life) and transient form (the least serious 2-3 years). Prevalence is estimated at 1/400,000. We report the sighting of a 12-year-old and 8-month-old girl, with no significant history, from a non-indigenous marriage. Presents since the age of 5 months a bilateral horizontal nystagmus, myoclonia and a psychomotor retardation and whose examination revealed a pyramidal syndrome and a discreet hepatomegaly. The biological balance objectivéhyperlactatemie, hyperammoniémieet Chromatography of Amino Acids in urine showed an increase in glycine, alanine and tyrosine with Amino Acid chromatography in the blood and chromatography of Organic Acids normal. MRI brain objectified a demyelinating aspect of the white substance and atrophy of the corpus callosum. PEV pathological retina-cortical conduction, PEA altered left, Muscle biopsy absence of shredded red fibers and genetic study confirms PelizaeusMerzbacher disease like.
D-dimer levels as an associated factor for pulmonary embolism in COVID-19 patients in Critical Care Unit: A case-control study
Authors: Marcela Cano Arboleda  , Juan Pablo Zuluaga-García  , Ricardo Uribe-Gonzalez  , Sara Moreno-Bedoya  , Andrea Sierra  , Andres Ramirez-Velez  , Jose Hugo Arias-Botero
Published: April 2024

Objective: Establish the association between the D-Dimer levels and pulmonary embolism (PE) in CT pulmonary angiogram (CTPA) in patients with COVID 19 in critical care. Methodology: Case Control study in patients with diagnosis of COVID 19 in three critical care units during 2021 in Medellin. All patients had CTPA as a diagnostic method for PE. Results: There were 135 cases and 136 controls, mean age 60 years old (IQ 51-70), 74.2 % were men. 39% had high blood pressure. Segmentary PE was found in 65.2%, lobar PE in 19.3% and 15.6% in the right or left pulmonary artery. We found that it is more likely to have PE if the D-Dimer value is more than 5000 ng/mL (ORa 7.8; IC95% 4.09-14.92). Conclusion: D-Dimer is an independent factor that is associated with PE in patients with COVID - 19 in critical care, especially if the value is over 5000 ng/mL.
Kohti ihmistä laajempaa kotia
Authors: Oulanne Laura
Published: April 2024

Koti toimii oletusarvoisesti näyttämönä intiimeille tunteille ja ihmissuhteille, ja siihen liitetään useita sukupuolittuneita arvoja. Artikkeli kysyy, miten ajallisia ja tilallisia skaaloja venyttävä kerronta voi siirtää perinteisesti kotiin liitettyjä affekteja ja arvoja ihmistä laajempaan kontekstiin, ja missä määrin tämä uudelleenkuviteltu koti voi tukea paitsi ihmiskeskeisyyttä vastustavaa, myös feminististä ajattelua. Tartun kahteen tutkimukselliseen katveeseen jääneeseen, omilla tavoillaan ekokriisin motiiveja hyödyntävään teokseen nykyisenlaisen ympäristötietoisuuden syntyvuosikymmeniltä. Stanley Crawfordin Log of the S.S. The Mrs Unguentine (1972) on avioliittokuvauksen tyylilajia parodioiva kertomus, joka sijoittuu vedenpaisumuksen jälkeisellä merellä seilaavalle proomulle, ja jossa perhe-elämän ja kotityön problematiikka sulaa kuvauksiin laivalle rakentuvan fantastisen ekosysteemin vaiheista. Joy Williamsin Breaking and Entering -romaanissa (1988) rakoilevan avioliiton näyttämönä sitä vastoin toimii hitaasti mereen uppoava Floridan rannikko ja rikkaiden talot, joihin sen päähenkilöt murtautuvat asumaan. Artikkeli tarkastelee kirjallisuutta affektien ja arvojen uudelleenkuvittelun potentiaalisena alueena ja kytkee ekonarratologisen keskustelun kerronnan mittakaavoista kirjallisuuden kotikuvausten feministiseen tarkasteluun.
Rakentaa vai kritisoida?
Authors: Rodriguez David
Published: April 2024

Levine, Caroline 2023: The Activist Humanist. Form and Method in the Climate Crisis. Princeton: Princeton University Press, 202 s.
Project module for strengthening the profile of Pancasila students in the perspective of 21st-century learning design microsoft
Authors: Prihantini Prihantini , Khoirunnisa Qori
Published: April 2024

The objective of this study is to identify and evaluate the content of the module in terms of 21st-century learning design (21 CLD) dimensions. This study adopts a qualitative approach by applying the content analysis method of Krippendorff's model. The object of content analysis is the project module for strengthening the profile of Pancasila students with the theme of local wisdom for phase A of elementary school. The researcher is the primary tool employed in this study. The content analysis instrument uses a rubric that microsoft developed to determine the dimension level of each learning activity in the module. The data is collected using six phases to analyze the content, explicitly unitizing, sampling, recording, reducing, abductively inferring, and narrating. The project module for strengthening the profile of Pancasila students was identified as containing 5 of the six dimensions of microsoft's 21 CLD.
Exploring college students’ technostress phenomenon in using ed-tech
Authors: Yunita Sri , Susilawati Susilawati , Riniawati Rina , Fajriah Yustika Nur
Published: April 2024

The intense use of technology might lead students to technostress. The present study intends to figure out the technostress experienced by university students on educational technology (ed-tech) used in their academic environment and the factors underlying the stress. A qualitative approach with a case study method was used to investigate those issues. An open-ended questionnaire was administered to gather the data. 46 students in the 5th semester majoring in the management study program of one private college in Garut, West Java, participated in this study. The findings revealed that from the facets of technostress, most of the students do not experience intense technostress due to habitual use of ed-tech, campus reasonable policy or demand, simplicity of university-proposed technology, lecturers' instructions, and peer abetment. However, the rest of the participants feel the force of using ed-tech, which is attributable to the shortage of campus facilities, the absence of comprehensive ed-tech guidance, lecturers' tendency for traditional instruction, the students’ insufficient technological competence, the matter of self-confidence and motivation, and health concerns. Potential implications for higher education institutions as the policymakers are discussed.
ScholarOne - Exploring the Importance of Student Centered Learning in Higher Education Based on Constructivist Theories of Teaching and Learning and Psychology
Authors: Cui Ziyu
Published: April 2024

Objective: The essay delves into the transformative changes witnessed in
teaching and learning over the last 30 years, with a specific focus on
the shift from teacher-centered to student-centered education in higher
education. Emphasizing the widely accepted notion that students should
be the focal point of the learning experience, the author aims to
explore the reasons behind the increasing importance of student-centered
learning in contemporary higher education classrooms. The background
sets the stage for a comprehensive examination of the subject,
emphasizing its relevance in the evolving educational landscape.
Methods: The methodology employed encompasses a multifaceted approach.
The essay initiates with a contextual overview, tracing the evolution of
learning models from teacher-centered to student-centered. This
historical perspective provides a foundation for a detailed literature
review. The author intends to define and contextualize student-centered
learning, drawing connections to constructivist theories of teaching and
learning. Additionally, the inclusion of personal experiences in a
constructivist classroom adds a practical dimension to the exploration.
This combination of historical context, theoretical grounding, and
personal insights forms the methodological framework of the essay.
Results: The anticipated results involve a synthesis of insights into
the benefits and implications of student-centered learning. The essay
aspires to shed light on how this approach positively influences various
aspects of student learning. The literature review is expected to unveil
the theoretical underpinnings supporting student-centered learning,
emphasizing its role in nurturing skills such as problem-solving and
critical thinking. The integration of personal experiences aims to
bridge the gap between theory and practice, providing a tangible
illustration of how student-centered principles manifest in real-world
educational settings. Conclusion: The article aims to synthesize the
diverse elements explored throughout the text. Acknowledging the
benefits of student-centered learning, the author contends that the most
effective outcomes are achieved when both cognitive constructivism and
social constructivism are in equilibrium within the student-centered
classroom.
ScholarOne - Rational and Irrational Beliefs and Coping Strategies Among Palestinian Refugees: An Exploratory Analysis
Authors: Aldahadha Basim
Published: April 2024

This study aimed to identify rational and irrational beliefs and coping
mechanisms that were expressed spontaneously by a sample of Palestinian
refugees (n = 35) during conditions of asylum and displacement after the
wars of 1948 and 1967. The participants ranged in age from 17 to 33
years when they sought refuge in Jordan and lived in camps. The coding
of the interviews into separate sentences and paragraphs showed that
93.8% of the participants expressed irrational beliefs while 51.3%
expressed rational beliefs. In addition, 78.2% of the participants used
and employed coping skills focused on emotions, while 49.8% used coping
skills focused on solutions. The most common irrational beliefs were
generalizations about others (85.5%) and exaggeration (63.7%). This
study provides the first information about the rational and irrational
beliefs of a sample of Palestinian refugees in Jordan in addition to the
coping strategies they employed to overcome the conditions of asylum,
which can be used in treating similar cases. This study is one of the
first studies worldwide to explore the extent of rational and irrational
beliefs among a sample of Palestinian refugees in Jordanian camps.
Keywords: rational, irrational, beliefs, coping strategies, refugees
ScholarOne - Development and test-retest reliability of an effector-specific stop signal task in young, healthy and active adults
Authors: Piskin Daghan , Gokeler Alli , Chen Yin-Hsuan , Baumeister Jochen
Published: April 2024

Inhibitory control has high significance in sports context in terms of
performance and injury prevention. Although it steps in during complex
maneuvers such as change of direction and deceleration, it is vastly
tested using computerized tests which require a simple finger movement.
This study aims to develope and assess the test-retest reliability of an
alternative stop signal task which is specific to lower extremities and
may provide an example in transition to mobile settings. Ten healthy and
physically active participants performed the effector-specific stop
signal task developed with the Fitlight System™ with a
one-week-interval. Four different stop signal delays were adopted which
were constant within the blocks. The main outcomes were determined as
reaction time, stop signal reaction time and response accuracy. The
effect of delay and time was explored using a 4x2 ANOVA. The test-retest
reliability of each outcome was assessed using intraclass correlation
coefficient. The findings showed a significant main effect of delay and
a significant interaction of delay and time. The overall reliability of
the reaction time, stop signal reaction time and response accuracy was
substantial, whereas differences were observed among stop signal delays.
Our findings may show that the suggested effector-specific stop signal
task may provide a reliable SSRT estimation during a stepping movement.
Further studies should consider different positions and tasks to
increase ecological validity.
ScholarOne - The impact of peer attachment on internet addiction among rural adolescents a moderated mediation model
Authors: tang jianping , xu sheng , Jiang Jing , Luo Tingrui , Wu Wenjing
Published: April 2024

The purpose of this study is to explore the mediating mechanism of peer
attachment in regulating internet addiction among rural adolescents. The
method used the Likert five point self-report scale for field sampling,
SPSS 25.0 software for data analysis, two tailed Pearson correlation
analysis, and regression analysis. As a result, peer attachment has a
direct impact of 0.36 on internet addiction and 0.48 on loneliness.
Loneliness has a direct impact of 0.52 on internet addiction, with a
mediating effect of loneliness is 0.249(0.48*0.52) ,it is a partial
mediator. The impact of the interaction between high and low shyness and
high and low peer attachment on loneliness is 0.44 and 0.12,
respectively. In the moderated mediating effect, the indirect moderating
effect of high shyness was 0.26, low shyness was 0.11, and the
difference between the two groups was 0.15.Conclusion:Peer attachment
has a positive impact on internet addiction among rural adolescents.
Loneliness plays a mediating role in peer attachment and internet
addiction. Shyness plays a differential regulatory role in the
relationship between peer attachment and individual loneliness, and the
indirect impact of peer attachment on internet addiction will be
enhanced or weakened by the strength of the mediating effect of
shyness’s differential regulation of loneliness.
ScholarOne - A validation study of the State Self-Esteem Scale-20 (SSES-20) and the State Self-Esteem Scale-6 (SSES-6) in a Spanish-speaking sample
Authors: Escrivá-Martínez Tamara , Molinari Guadalupe , Ciudad Victor , Corno Giulia , Baños Rosa
Published: April 2024

The State Self-Esteem Scale has not been studied in Spanish population
yet. The first objective was to test the factor structure and internal
consistency of the State Self-Esteem Scale (long and short versions,
SSES-20 and SSES-6) in a Spanish-speaking sample. The second objective
was to assess the convergent and discriminant validity by examining its
relationships with variables such as trait self-esteem, social
desirability, depression, and anxiety. The whole sample was composed of
713 Spaniards (79.4% female; Mage = 24.75 years). Results suggest that
the bifactor model with a general factor and three subdimensions better
fit the data in the SSES-20. For the SSES-6 version, the hierarchical
model with three correlated first-order factors and a common superior
factor was found to be the best fit for the data. All dimensions showed
moderate to excellent reliability. All factors were positively
associated with trait self-esteem and social desirability, and inversely
associated with depression and state anxiety. Lastly, performance,
appearance, and social state self-esteem dimensions from the SSES-20
positively predicted depression and state anxiety using linear
regression models. Both the Spanish SSES-20 and SSES-6 showed adequate
psychometric properties within this sample, suggesting potential
generalizability to different Spanish samples.
ScholarOne - Teacher identity construction from epistemological and axiological perspectives in Tanzanian schools
Authors: Lawrent Godlove
Published: April 2024

This study gained insights into how the secondary education expansion
policy shaped teacher identity. A qualitative case study design was
adopted, and interviews and document analysis were used for data
gathering. The main participants were teachers and school principals
from the Iringa region, Tanzania. It was revealed that the inadequate
policy enactment adversely affected teachers’ own perceived teaching
aptitudes, and intensified them to behave unprofessionally. These issues
prompted the teaching profession to lose social standing. The study adds
to a growing body of literature on how teachers “construct” what
secondary expansion means for them as both effective and ethical
professionals.
Restoration manager: Adapting project delivery methods for the restoration of architectural heritage
Authors: Aktuna Mehmet Emre , Eskici Bekir
Published: April 2024

The restoration of architectural heritage is a complex process and presents intricate and formidable challenges. The project delivery method plays a pivotal role for the success of the restoration process. There exists a diverse array of project delivery methods, each characterized by its distinct set of advantages and disadvantages. In the context of architectural heritage restoration, given its distinct characteristics, these advantages and disadvantages encompass a wide spectrum. Current project delivery methods, while effective for certain contexts, often fall short in addressing the unique requisites of restoration projects. Acknowledging this inadequacy, this article undertakes a research that includes a literature review that not only examines prevailing project delivery methods but also articulates the need for a tailored framework within the restoration field. This article is produced from the doctoral thesis titled "Development of a Sustainable Integrated Management System for the Conservation of Architectural Heritage", which is in the process of preparation. In the light of the results of the survey which is conducted within the scope of the first author's doctoral study in order to examine the project delivery approach preferred among the participants that are working in the field of the conservation of architectural heritage, a project delivery method called "Restoration Manager", which has been precisely prepared to meet the requirements inherent in restoration initiatives, is presented. This comprehensive project delivery method seeks to fill the void by addressing the distinct needs and challenges encountered in restoration projects. The essence of this work is to create an appropriate project delivery system that adapts to the nuances of the restoration works, and through this project delivery framework, the restoration processes and outcomes will successfully be completed.
Improving of Paraffin Wax Properties by Adding of Low Density Polyethylene (LDPE)
Authors: Yousif Siham Mezher , Mohammed Intisar Yahiya , Mouhy Salma Nagem
Published: April 2024

Petroleum wax is a polymer completely similar to ethylene with a high degree of crystalline and linearity. The method of mixing polymer with wax is one of the most common methods used in the field of improving the specifications of polymeric materials and making them widely used in various industrial fields. By mixing wax with different proportions of the polymer, to obtain better specifications in terms of solubility, hardness, thermal stability, and chemical resistance. Thus, it can be used in the electrical industries. This study examines some characteristics of the prepared wax such hardness, melting point, ash percentage, and electrical conductivity.
The process of mixing with different percentages of wax, polyethylene and nano silver led to a clear increase in the electrical conductivity property, as the increase in the proportion of nano silver led to an increase in electrical conductivity. The polymer worked to prevent silver nanoparticles from clumping and making them cover the surface of the polymer, and thus an electrical circuit was made without metal wires.
Where Have All the Alphas Gone? A Meta-Analysis of Hedge Fund Performance
Authors: Yang Fan , Havranek Tomas , Irsova Zuzana , Novak Jiri
Published: April 2024

We examine the factors influencing published estimates of hedge fund performance. Using a sample of 1,019 intercept terms from regressions of hedge fund returns on risk factors (the alphas) collected from 74 studies, we document a strong downward trend in the reported alphas. The trend persists even after controlling for heterogeneity in hedge fund characteristics and research design choices in the underlying studies. Estimates of current performance implied by best practice methodology are close to zero across all common hedge fund strategies. Additionally, our data allow us to estimate the mean management and performance fees charged by hedge funds. We also document how reported performance estimates vary with hedge fund and study characteristics. Overall, our findings indicate that, while hedge funds historically generated positive value for investors, their ability to do so has diminished substantially.
Novel Parent Survey Measures Sensory Behaviors Incorporating Sensory Modality and Stimulus Intensity
Authors: Yee Connor , Rather Ellie , Hoque Sakib , Lee Joon , Marton Stephanie , Roth Jill , Oswald Frederick Louis , Nobleza Kenneth , Banerjee Ankona , Harris Holly , Lyons-Warren Ariel
Published: April 2024

Objective: Sensory behaviors are common clinically relevant features of many neurodevelopmental disorders including Autism. However, existing assessments critically lack granularity in evaluating hypersensitivity and hyposensitivity, particularly in relation to stimulus intensity. We address this gap by developing the Sensory Response Questionnaire Phenotyper (SRQP), a parent questionnaire that comprehensively assesses sensory behaviors across five sensory modalities. Here we report the development of the SRQP, validation against established tools and assessment of its effectiveness in identifying nuanced sensory processing patterns in children with Autism.Methods: A convenience sample of 317 participants (57 with Autism, 260 typically developing) aged 3-17 years were enrolled in a cross-sectional study. The SRQP’s psychometric properties were analyzed using classical test theory (CTT), and item response theory (IRT). Statistical tests were used to evaluate patterns of sensory processing from SRQP results.Results: Data from 271 participants were included. The SRQP demonstrated strong psychometric properties: a receiver operating characteristic (ROC) curve analysis identified 37 as the cut-off value for most accurately distinguishing between typical and atypical responses on the SRQP (sensitivity 0.75, specificity 0.79, AUC 0.87). Total but not modality-specific hyper vs hyposensitivity scores were moderately correlated (ρ = .5). Responses to high-intensity stimuli were not correlated with responses to low-intensity stimuli for auditory, visual, taste, or tactile hyposensitivity (ρ < .4).Conclusion: The SRQP is a new validated parent questionnaire to assess multi-dimensional properties of sensory behaviors. Stimulus intensity is an important parameter of sensory behaviors that should be accounted for in future models.
Negative Capability in Keats’s “Ode to Autumn”
Authors: Kandel Churamoni
Published: April 2024

This paper examines and analyzes the ideations of negative capability postulated by Keats in his “Ode to Autumn”. His negative capability embraces uncertainty, doubt, and ambiguity in poetry, without seeking to impose rational explanations or resolutions. He employs the third- person narration, depersonalized imagery, universal themes, and avoids using personal pronouns in writing the odes. These aspects expose his fundamental concept of negative capability because he desires to remain in doubt, uncertainty, and mysteries by the process of depersonalization of the authorship. He explicates the true nature of beauty in his “Ode to Autumn”. He embraces the mystery and complexity of the ripening of fruits like grapes, apples, gourd and hazelnuts. The bee-hives are filled with honey. The season embodies the contrasting qualities with their harmonious coexistence. Keats explores the occupations of autumn. The season performs various activities in the form of a reaper, a winnower, a gleaner and a cider –presser. Keats juxtaposes the activities of life as well as the passivity/ death in these occupations. He introduces the songs of autumn. The mournful sounds of the gnats, the bleating of the lambs, the singing of the crickets, the whistling of the redbreast and the twittering of the swallows offer the music of autumn. The ambiguities of the abundance and the decline in these songs reflect the cyclical nature of the autumn season. This paper applies the dynamics of the qualitative approach, with an interpretive research design to unveil the beauty of the autumn season.
Role of Earliest Arrival Flow in an Evacuation Network
Authors: Adhikari Iswar Mani
Published: April 2024

Traffic route guidance, destination optimization, and optimal route choice are some of the approaches to accelerate the evacuation process of transit-based evacuation problems. Their effectiveness depends upon the evacuee arrival patterns at the pickup locations and their assignment in an appropriate way to the resources in the network. The arrival patterns of the evacuees at different pickup locations might be a constant or random variable, deterministic or stochastic, time-dependent, or flow-dependent, or can be categorized either way. In this work, we are focused on the collections of evacuees at the pickup locations from the danger zone in the earliest arrival flow patterns, which can be further assigned to the transit vehicles in the integrated evacuation network by treating such pickup locations as the sources for the subsequent process to minimize the overall network clearance time from the danger zone to the safety.
A Novel Approach for the Particle-in-Cell Modelling of Gridded Ion Engine Plume Neutralisation
Authors: Parke Sturrock Joseff Ian , Jelic Z. , Evans Ben , Davis R. J.
Published: April 2024

The Particle-in-Cell modelling of gridded ion engine plume neutralisation has been simplified when compared to traditional methods. This results in significantly less computational resources being required. The NSTAR engine was modelled as a reference, where simulated specific impulse values were found to be 5% higher than the real engine. This method will be most suited to rapid prototyping and optimisation studies, where speed of simulations is an important factor.
On fusion chain reactions in 11B targets for laser driven aneutronic fusion
Authors: Gruenwald Johannes
Published: April 2024

The work presented in this letter suggests that it is possible to enhance the yield in laser driven aneutronic fusion devices by fusion chain reactions. This mechanism will be described using the example of aneutronic fusion between an incoming high-energy proton beam and a 11B target. Such fusion reactions create alphas that can again fuse with a 11B particle in a dense solid state target. An improved target design will be shown that enhances the recycling of fast alpha particles that are created from fusion reactions. It will also be argued that such alpha recycling may have already been observed in experiments, although it was attributed to another, more complex physical mechanism.
EPIDEMIOLOGY OF MENTAL HEALTH DISORDERS: FROM PREDICTORS TO CONSEQUENCES
Authors:   Belarusian State Medical University, Minsk, Republic of Belarus, Valchuk Irina N. , Kirilenko Ekaterina S. ,   Belarusian State Medical University, Minsk, Republic of Belarus
Published: April 2024

Introduction. Due to the high social significance of mental health disorders, the study of the spread and degree of influence of modifiable predictors of depressive psychoemotional status can contribute to the development of new approaches to active prevention. The purpose of the study. To study the epidemiological characteristics of mental health disorders and identify key predictors among students. Methods. To conduct the study, epidemiological diagnostic methods were used, such as: retrospective epidemiological analysis, descriptive and evaluative methods, as well as statistical methods, methods of epidemiological diagnostics using methods of clinical epidemiology and statistical analysis were used. Results. There was a moderate long-term epidemic trend towards an increase in the incidence of mental disorders (an increase rate of 3.68%) and a high long-term average (164.44+1.72о/оооо). The risk area is determined on the basis of the characteristic pronounced tendency to growth and an increased level of relative epidemiological risk: Minsk region, Minsk, Vitebsk and Mogilev regions (Tpr = 6.56%, 9.99%, 15.21%, and 15.57%, respectively. Consequently, the risks were: in Minsk – 0.77, in Vitebsk and Mogilev regions – 0.78 and 0.86, respectively). The result of our own original research was the identification of a depressive state in 59.25% of cases and generalized anxiety disorder – in 64.1% of cases. An aggravating circumstance is the fact of comorbidity in more than 80% of cases. When studying the epidemiological characteristics of these disorders, significant predictors were identified that increased the chance of developing a state by 2.5-11.5 times. Conclusion. The high levels of prevalence and comorbidity of depressive psychoemotional status and anxiety disorder characterize the general epidemiological situation within the mental health of students as unfavorable and require the development of preventive measures.
Application of polymer concrete containing industrial bottom ashes in footing plates for energy poles
Authors: Korol Jerzy , Skotniczy Grzegorz , Kozioł Mateusz , Chmielnicka Ewelina , Kowalik Magdalena
Published: April 2024

The paper presents a procedure of preparing, molding and testing polymer concrete containing 10 – 60% of bottom ash from power plant fluid circulating fluidized bed boiler (CFB)– the rest of the filler was a standard sand. The tests of static bending and mass changes after exposition to acid, base and salt were conducted. Also mass changes after freeze-thaw tests were registered. The tested polymer concretes showed no problems during manufacturing procedures. Compositions containing 10 - 20% by weight of the ash showed higher flexural strength than polymer concrete containing 100% sand and it was about 35 MPa. Relatively small changes in mass (less than 0.5% excluding base exposition for which it was less than 3%) caused by environmental factors, in general consistent with theoretical predictions, allow us to assume that the tested materials will meet the strength requirements for the footplates. It is studied in second part of the set. According to the environmental resistance and description of a whole designing and production process. It was found that the concrete containing 10%wt of the ash is optimal material for producing the plates. It has showed the best resistance to environmental aging from all tested concretes. The designed mold system is simple and reliable - it is applicable for serial production of the plates in industrial conditions. Visual quality of the produced plates was very good. In general, polymer concrete once again turned out to be very good material, applicable in various elements for construction industry.
The Prevalence of Hospitalized Parkinson’s Disease Patients in All Case Hospitalization among Different Race/Ethnic Subgroups in Hawaii
Authors: Bruno Michiko Kimura , Matsunaga Masako , Krening Emma , Gao Fay , Chen John J. , Seto Todd , Ross G. Webster
Published: April 2024

Background:

Little is known about the epidemiology of Parkinson’s disease (PD) patients in Native Hawaiian Or Other Pacific Islander (NHPI) and Asian American (AA) subgroups.

Objective:

To determine if the prevalence of hospitalized PD patients is different across age groups and racial/ethnic subgroups in Hawaii.

Methods:

We conducted a retrospective analysis of Hawaii statewide registry (2016–2020) hospitalization data for patients who were 50 years or older. PD patients were identified using an ICD 10 code: Parkinson’s Disease (G20) as their primary/secondary hospitalization discharge diagnosis code. Demographic and clinical characteristics among racial/ethnic subgroups (White, Japanese, Filipino, Chinese, NHPI, or Other) were compared.

Results:

Of 146,844 total hospitalized patients ( n = 429,879 records), 1.6% ( n = 2,401) had a PD diagnosis. The prevalence of hospitalized PD patients was 2.3% among Japanese and Chinese, followed by 1.7% for Whites, 1.2% for Filipinos and was lowest for NHPI with 0.9% ( p < 0.001). As patient’s age increased, the prevalence of hospitalized PD patients increased, with 80–84 years old for the highest age range (3.4%). The prevalence of hospitalized PD patients at 80–84 years old varied across the race/ethnic subgroups (Chinese 4.3%, Japanese 4.0%, Whites 3.7%, Filipinos 2.5%, NHPI 2.3%).

Conclusions:

The prevalence of hospitalized PD patients among all case hospitalizations were lower for NHPI and Filipino compared to that of Japanese, Chinese, and Whites. As patients’ age increased, the prevalence of hospitalized patients with PD increased, but less so in NHPI and Filipino groups. Further research is warranted to understand the reason for these observed differences among racial/ethnic subgroups.
Combating Child Sexual Violence And Exploitation: Psycho-Legal Experience Of Ukraine And The World
Authors: Filipenko Nataliia , Spitsyna Hanna , Lukashevych Serhii , Yazan Nataliia , Slipets Olena
Published: April 2024

Summary. The article examines issues related to Ukrainian and international experience in combating sexual violence and exploitation of children. At the same time, the book highlights that crimes related to sexual violence and child exploitation can cross borders when the perpetrator lives in one country and the victim in another. In cases of child sexual exploitation, the service provider is often a resident of another state. Therefore, legal approaches aimed at preventing and combating sexual violence and exploitation of children should be coordinated and coordinated as much as possible, in order to avoid that perpetrators of sexual crimes against children direct their efforts towards countries where children are more vulnerable, as such people know.

The authors note that ending violence against children requires both primary prevention and effective countermeasures. Primary prevention aims to address underlying beliefs, attitudes and behaviors, inequalities, risks and drivers of violence at the level of the individual, family and relationships, community, organization /institution and the broader social and political context.

Therefore, in order to combat sexual violence and exploitation of children, it is necessary to develop and implement in the life of the Ukrainian community effective strategies to end violence against children, which should include all forms of violence, whether physical, emotional, psychological, sexual violence or outrage.
Peculiarities Of Investigating Negligent Severe Or Moderately Severe Bodily Harm At The Initial Stage
Authors: Penzieva Kateryna
Published: April 2024

One of the important stages in the development of a separate sub-type methodology for investigating negligent severe or moderately severe bodily harm is the determination of the specifics of the initiation of criminal proceedings based on this fact and circumstances to be established during investigation of the specified criminal offense.

Conducting a study of this issue will serve to eliminate the gap in forensic science, since currently the indicated methodology has not yet been developed.

The Article purpose is to provide scientifically-based criminological recommendations regarding the specifics of initiating a pre-trial investigation into the infliction of negligent severe or moderately severe bodily harm. This includes outlining a set of investigative (search) and other procedural actions based on various typical investigative situations, with a focus on determining circumstances to be established during investigation of this crime.

An analysis of investigative and judicial practices was conducted to study the methods used in investigating specific types of criminal offenses, peculiarities of initiating pre-trial investigations for the specified criminal offense. As a result, information sources about the committed crime have been determined.

The tasks that must be solved by a person conducting a pre-trial investigation at its initial stage are formulated. The most typical investigative situations at the initial stage of investigating negligent severe or moderately severe bodily harm have been determined, taking into account informational, psychological, tactical, and procedural factors affecting their formation. The main investigative situations occurring during investigation of the specified type of crime are:

- Investigative Situation No. 1. At the time of opening a criminal proceeding, there is information about a person’s identity and his/her whereabouts; the suspect has been apprehended.

- Investigative situation No. 2. The offender’s identity is known, but his/ her whereabouts has not been established.

- Investigative situation No. 3. The suspect’s identity and his/her whereabouts are unknown.

Depending on each specific investigative situation, recommendations are provided regarding the optimal conduct of a pre-trial investigation at this stage, namely, a list of tasks, investigative (search) and other procedural actions.

The list of circumstances to be established during investigation of criminal offenses based on the fact of negligent infliction of severe or moderately severe bodily harm is defined.
Features Of Tactics And Fixation The Results Of A Search Carried Out With The Participation Of A Specialist
Authors: Kovalenko Oksana
Published: April 2024

One of the procedural actions is a search, the tactics of which was and continues to be a topic discussed in the legal literature. It is axiomatic that the effectiveness of the search is determined not only by the competence and coherence of the actions of its participants but also by the expertise of the specialists involved. The purpose of the article is to elucidate the problematic moments of conducting and recording the results of the search, in which specialists took part, formulating scientifically based recommendations aimed at solving them and minimizing the negative impact. Based on the analysis of investigative and judicial practice, it was determined that typical mistakes made by investigators during a search, the participants of which are specialists of various specialties, include the following: entrusting the investigation (search) action to the involved knowledgeable persons; improper recording in the protocol of the actions taken by the specialists, etc. The importance of researching this issue and eradicating similar mistakes from investigative practice, in particular by conducting educational and scientific activities, to increase the professional competence of representatives of the prosecution, was emphasized.
Influence of Animal Nutrition on Milk Quality With Special Reference to the Fatty Acid Composition of Milk Fat
Authors: Kowalska Malgorzata Katarzyna , Mitrosz Paulina , Żbikowska Anna , Molik Artur
Published: April 2024

The aim of this study was to compare the composition of fatty acids (FA) present in raw milk. The variable factor that was used was the type of food that was fed to the cows from which milk was collected and time of year. Special attention was paid to the FA factor important in human nutrition.
The animals from which the raw material was collected were kept in a traditional system. i.e. in an alcove-pasture system (farm A) and in an alcove system with the use of food delivered by a mixer feeder wagon (farm B). The study material consisted of collected milk, which was tested in 12 replications at each farm during the winter as summer season in 2019. The FA content showed variability for cows grazed on a pasture farm in the summer compared to little changes in the FA obtained from cows fed on the TMR feeding system.
The FA content showed variability for cows grazed on a pasture farm in the summer compared to little changes in the FA obtained from cows fed on the TMR feeding system.
In general, the study showed that the choice of feed and the season in which the animals are fed are important, as these factors affect milk fat (fatty acid) and, more specifically, have an impact on the overall quality of the milk.
Validation of Novel High-Performance Liquid Chromatography Method for Meropenem Quantification in Plasma
Authors: Rančić Aleksandar , Folić Marko , Petrović Nemanja , Ilić Todorović Violeta , Stanojević Milica , Milosavljević Miloš , Milentijević Milica , Janković Slobodan
Published: April 2024

Eminent societies of clinicians worldwide advise the implementation of therapeutic monitoring of meropenem. Our aim was to validate the new high-performance liquid chromatography (HPLC) technique for the measurement of meropenem in plasma that we developed. The validation of the method was performed in accordance with the official European Medicines Agency (EMA) guideline for bioanalytical method validation through the assessment of the following validation parameters: linearity and limit of detection/quantification, trueness and precision, recovery, selectivity, matrix-effect assessment, dilution integrity, carry-over assessment, and stability. Our calibration curve was found to be linear over the concentration ranges of 1.25–100 μg/mL, which covers the therapeutic range of meropenem in patients. From the calibration curve, the limits of detection and quantification were calculated to be 0.4 μg/mL and 1.2 μg/mL, respectively. Recovery ranged from 81.7 to 95.9 percent. Intra-day truennes ranged from −1.9 to 2.6% and inter-day trueness ranged from −4.7 to 3.8%. Intra-day precision was less than 4 percent, while inter-day precision was less than 7 percent. Meropenem remained stable in the patient plasma sample for one week at −20°C. Our HPLC technique can be applied in clinical practice for the therapeutic monitoring of meropenem in critically ill and other vulnerable patients since it is simple, rapid, and reliable.
Inhibitors of CK2 Kinase for the Treatment of Gliomas and Other Brain Tumors
Authors: Pucko Emanuela B. , Ostrowski Robert P.
Published: April 2024

Protein kinase CK2 has become a target of experimental antiglioma therapies as laboratory data are almost uniformly favorable and the number of synthetized CK2 inhibitors is rapidly growing. The evidence of their use for other brain tumors is on the increase as well. Great expectations are entrusted in naturally occurring compounds capable of inhibiting CK2 kinase. These compounds are extracted and purified by means of biochemistry methods and are amenable for innovative drug delivery systems as well. CK2 kinase inhibitors have been proven suitable for combined therapies with other investigational antiglioma agents and treatment modalities. However a greater share of efforts should be undertaken towards inhibiting functions relatively specific for glial tumors including infiltrative growth and invasiveness or maintenance of glioma initiating cells. Many of these function appear to converge on mTOR and JAK/STAT pathways which are being meticulously studied in this respect. Protein kinase CK2 holds therapeutic promise especially when combined with other agents aimed at molecular signatures of gliomas.
Current State of Community Pharmacist-Physician Collaboration — A Cross-sectional Survey Among Pharmacists
in Poland
Authors: Wrześniewska - Wal Iwona , Pinkas Jarosław , Jankowski Mateusz
Published: April 2024

A patient-centered partnership between different healthcare professionals is critical to improving the quality of health services. While the cooperation of physicians, nurses, midwives, and paramedics is well documented, more and more attention is paid to the role of pharmacists in interdisciplinary care. This study aimed to evaluate the pharmacist’s perception of the current state of community pharmacist-physician collaborative working as well as to identify barriers to the implementation of the community pharmacist-physician collaborative working model in Poland. This cross-sectional survey was carried out between October and December 2022 among community pharmacists in Poland. A total number of 1327 pharmacists from one of the largest franchise chain pharmacy networks in Poland were invited to take part in this study. The study questionnaire included 23 questions on the current state of pharmacist-physician collaborative working, the scope of cooperation, barriers to cooperation, and educational and organizational needs. Completed questionnaires were received from 635 pharmacists (response rate of 47.9%). Formal correction of the prescription (91.3%) was the most common cause of pharmacist-physician collaborative working. Moreover, 62.7% of pharmacists indicated that modification of ordered drugs was the reason for pharmacist-physician collaborative working. Only 3.3% of community pharmacists indicated that they collaborate with physicians during the drug review. Lack of IT systems enabling pharmacist-physician collaborative working (67.6%) and lack of recommendations on pharmacist-physician collaborative working (57.3%) were the most common barriers to collaboration with the physician. Pharmacists declare their readiness to cooperate with physicians, but there is a need to strengthen trust between both groups.
Effect of ACEA 1021 on Neurotoxicity Induced by Dexamethasone — Initial Behavioral Study
Authors: Krasuska-Grzegorczyk Beata , Komsta Łukasz , Danilczuk Zofia
Published: April 2024

Considerable evidence suggests that glucocorticoids (GCs) play an important role in neurodegeneration. Chronic elevated levels of GCs can result in neuronal degeneration of the hippocampal piramidal neurons, which are paralleled by cognitive deficits. Moreover, GCs potentiate stress or ischemia-induced accumulation of excitatory amino acids (EAA) in the extracellular space of hippocampus. ACEA 1021 (licostinel), a selective antagonist of the N-methyl-D-aspartate (NMDA) receptor, has been reported to prevent the excitotoxic action of high extracellular glutamate levels. The aim of this study was to investigate the effect of ACEA 1021 on neurotoxic effect of dexamethasone (DEX - a synthetic GCs receptor agonist). The experiments were carried out on Albino Swiss mice (25-30 g). ACEA 1021, at the doses: 1.25 and 2.5 mg/kg/day, ip, was administered 15 min before DEX (16 mg/kg/day, ip). The long-term memory acquisition (passive avoidance test) and the motor performance (“chimney” test) were evaluated 14 days after the drugs administration. The prolongation of climbing time in the “chimney” test and decrease of the retention time in the memory task of mice treated with DEX for 14 days. In mice treated with DEX for 14 days, ACEA 1021 at the both doses reduced the climbing time in the “chimney” test, at the dose of 1.25 mg/kg improved memory acquisition. The above findings suggest that ACEA 1021 could prevent the neurotoxic effects induced by DEX, but further study needs to be carried out to explain this effect.
Acknowledgement to Reviewers 2023
Authors: Tomczyk Michał
Published: April 2024

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