bluuebunny/crossref_metadata_2025 huggingface dataset:
From Bakery Leftovers to Brewing Sustainability: Fermentation of Spent Grain with Yarrowia lipolytica and Lactobacillus acidophilus
Authors: Lalić Anita , Jagelavičiūtė Jolita , Rezić Tonči , Trivunović Zorana , Žadeikė Daiva , Bašinskienė Loreta
Published: January 2025

The use of bakery leftovers as a substitute for malt in brewing represents a sustainable approach that reduces costs and waste. In this paper, the fermentation of brewer’s spent grain, a byproduct of beer production, is integrated with the use of non-conventional yeasts to unlock the potential of yeasts beyond the common Saccharomyces species. This creates a circular system where byproducts are efficiently utilized, fostering sustainability and innovation in food production. This study assesses the fermentative capabilities of the non-conventional yeast Yarrowia lipolytica and the lactic acid bacterium Lactobacillus acidophilus DSM 20079 on brewer’s spent grain, a byproduct from brewing beer with old wheat bread and barley malt. Both hydrolyzed with a cell-wall-degrading enzyme complex and non-hydrolyzed brewer’s spent grain were evaluated for key fermentation indicators such as the number of microbial cells, total titratable acidity, pH, reduced sugar content, and fatty acid composition. The findings reveal that Yarrowia lipolytica effectively fermented brewer’s spent grain without prior hydrolysis, maintaining a balanced fatty acid profile. The combined action of both microorganisms provided optimal fermentation outcomes, offering a promising approach for valorizing brewer’s spent grain, reducing waste, and promoting a circular economy in the brewing and food industries.
Sustainable Design: Minimizing Discomfort Glare Through Data-Driven Methods for Responsive Facades
Authors: Matin Negar Heidari , Eydgahi Ali , Gharipour Amin
Published: January 2025

Ensuring visual comfort for occupants in sustainable buildings involves addressing discomfort glare and its associated risks. Responsive facades, designed based on pre-set algorithms, enhance visual performance and reduce discomfort glare by continuously adapting to changes in daylight intensity, reflection, or color. In this study, computational models were developed by incorporating hourly daylight glare probability (DGP) with occupants’ spatial data and facade active variables to minimize discomfort glare for responsive facades. To evaluate these models, a room with an office setting was parametrically simulated with a responsive facade, generating hourly DGP data for an entire year across different facade configurations, building orientations, and climate zones. The Exhaustive Search Algorithm was then used to calculate the optimal hourly angles for the facade configurations. The results indicate that the proposed models can significantly maintain DGPs within an imperceptible range (<0.35) in all scenarios compared to a no-louver scenario. These models offer valuable insights for architects, facade designers, and researchers aiming to enhance occupant visual comfort and productivity through innovative responsive facade strategies. Aligning visual comfort, well-being, and productivity with sustainability ensures that buildings operate efficiently while providing a healthy and comfortable environment for users.
Dynamic of Land Use and Associated Ecosystem Service Value in the Chengdu–Chongqing Urban Agglomeration, China
Authors: Jiang Qingyang , Li Bochao , Su Chao , Tang Xuguang
Published: January 2025

Understanding the long-term land use changes in the Chengdu–Chongqing urban agglomeration, a vital element of the Yangtze River Economic Belt and a key economic growth center in western China, can offer scientific basis and policy direction for improving regional ecosystem service values (ESVs), environmental conservation, and sustainable development. This study investigated the features connected to land use change, changes in landscape patterns, and variations in ESV across this region by means of time series of remote sensing and socio-economic data from 1990 to 2020. Additionally, the correlations between landscape pattern indices and ESV were examined. The findings indicated that: (1) cultivated land and grassland in the Chengdu–Chongqing urban agglomeration exhibited a declining trend, while forest, water, and construction land demonstrated increasing trends; (2) human activities significantly affected the Chengdu–Chongqing urban agglomeration, resulting in severe landscape fragmentation, heterogeneity, complexity of types, and patch separation, although the predominant patch types maintained strong connectivity; (3) the ESV of the Chengdu–Chongqing urban agglomeration initially decreased, reaching a minimum of CNY 5.017 billion in 2000, and subsequently rose again. Forest land accounted for approximately 69% of the overall ESV in the region over the preceding decades. The policy of reverting farmland to forest, the establishment of wetland parks, and the increased awareness of environmental protection have led to notable alterations in land use types and landscape patterns within the Chengdu–Chongqing urban agglomeration, which can significantly improve the regional ecosystem service value; however, the extent of influence and trends among various landscape indices are disparate.
Dynamic Stress Analysis of a Strip Plate with Elliptical Holes Subjected to Incident Shear Horizontal Waves
Authors: Cheng Yuzhen , Zhao Yuanbo , Han Kun
Published: January 2025

The dynamic stress analysis of a strip plate with elliptical holes under the action of an incident SH wave was performed using a complex function method and a successive mirror method. Firstly, a complex plane coordinate system of elliptic holes was established by using the complex variable function method and integral transformation method. The elliptic hole wave field and stress were established using the wave function expansion method. Then, the relation between the argument angle of any point on the edge of the ellipse hole and the angle between the vertical line and the coordinate axis was established. Using boundary conditions to solve the unknown coefficients in the equation, finally, the integral equation was simplified to a linear equation by means of the effective truncation method, and the steady-state response of dynamic stress under different parameters was analyzed. In addition, by comparing the finite element solution with the numerical solution, the accuracy of the results was effectively verified. The results show that the studied geometric model can provide solid theoretical support for the inspection of plate and shell structures, which is of great significance in practical engineering.
Short-Term Oral Administration of 1.5 μg/kg bw/day of Deoxynivalenol Significantly Exacerbates Inflammatory and Itching Symptoms in a Mouse Model of Imiquimod-Induced Psoriasis
Authors: Miyamoto Takayoshi , Komuro Mariko , Aihara Ryota , Ohira Chiharu , Kaneki Mao , Iwashita Naoki , Takagi Yoshiichi , Miyasaka Atsushi , Kushiro Masayo , Miyake Shiro , Fukuyama Tomoki
Published: January 2025

Deoxynivalenol (DON) is a mycotoxin commonly found worldwide and is implicated in various health effects. We recently demonstrated that subacute oral exposure to DON significantly exacerbates symptoms of type 2 helper T-cell-mediated allergic diseases in a model. We aim to investigate the role of oral DON exposure in type 17 helper T-cell-mediated immunoreactive diseases using a mouse psoriasis model. Psoriasis was induced by the dermal administration of 5% imiquimod in female BALB/c mice. A standard rodent diet was supplemented with DON to achieve a final concentration of 0.3 ppm (1.5 μg/kg bw/day), which was administered daily for 14 days. Skin thickness, scratching behavior, and transepidermal water loss (TEWL) were continuously measured during imiquimod administration. Mice exposed to DON exhibited significant increases in skin thickness, TEWL, and scratching behavior. Histological evaluations revealed aggravated hyperplasia, neutrophil infiltration, and inflammatory cell accumulation in the dermis. Furthermore, DON exposure significantly increased the number of CD4+ helper T cells and CD11c+ MHC class II+ dendritic cells in the auricular lymph nodes, along with elevated TNF-α and IL-17 levels in stimulated T cells. The gene expression of IL-17 in skin tissue was also significantly up-regulated in DON-treated mice. Collectively, these findings suggest that oral exposure to DON aggravates symptoms in a mouse psoriasis model.
Characterization of Endogenous Retroviral-like Particles Expressed from the Spodoptera frugiperda Sf9 Cell Line
Authors: Ma Hailun , Bae Eunhae H. , Chin Pei-Ju , Khan Arifa S.
Published: January 2025

The Spodoptera frugiperda Sf9 insect cell line is used in the baculovirus expression vector system for the development of various viral vaccines and some gene therapy products. Early studies indicated that Sf9 cells produced a reverse transcriptase (RT) activity that was detected using a sensitive PCR-enhanced reverse transcriptase (PERT) assay. Since RT is generally associated with retrovirus particles, we undertook the investigation of the physical properties and infectious nature of the extracellular RT activity that was constitutively expressed from Sf9 cells or induced after the chemical treatment of the cells with drugs known to activate endogenous retroviruses. A density gradient analysis indicated that the peak RT activity corresponded to a low buoyant density of about 1.08 g/mL. Ultracentrifugation and size filtration of cell-free Sf9 supernatant indicated that different particle sizes were associated with the RT activity. This was confirmed by transmission electron microscopy and cryoEM, which revealed a diversity in particle size and type, including viral-like and extracellular vesicles. The treatment of Sf9 cells with 5-iodo-2′-deoxyuridine (IUdR) induced a 33-fold higher RT activity with a similar low buoyant density compared to untreated cells. Infectivity studies using various target cells (human A204, A549, MRC-5, and Raji, and African green monkey Vero cells) inoculated with cell-free supernatant from untreated and IUdR-treated Sf9 cells showed the absence of a replicating retrovirus by PERT-testing of cell-free supernatant during the 30 day-culturing period. Additionally, there was no evidence of virus entry by whole genome analysis of inoculated MRC-5 cells using high-throughput sequencing. This is the first study to identify extracellular retroviral-like particles in Spodoptera.
Bovine Serum Albumin Nanoparticle-Mediated Delivery of Ribavirin and Mycophenolic Acid for Enhanced Antiviral Therapeutics
Authors: Castañeda Cataña Mayra A. , Rivas Marquina Andrea P. , Dodes Traian Martín M. , Carlucci M. Josefina , Damonte Elsa B. , Pérez Oscar E. , Arrua Eva C. , Sepúlveda Claudia S.
Published: January 2025

The global spread of viral diseases is a public health issue. Ribavirin (RBV) and mycophenolic acid (MPA) are well-known wide-spectrum antiviral agents. The present study evaluated the potential of bovine serum albumin (BSA) nanoparticles (NPs) as a vehicle to improve the efficacy of molecules with antiviral activity. The results demonstrated that NPs offer a promising strategy for the delivery of antiviral drugs, improving their stability and reducing toxicity compared to free agents. BSA-based NPs effectively encapsulated hydrophilic molecules such as MPA and water-soluble compounds such as RBV, achieving encapsulation efficiencies of 10% and 20%, respectively. The purified NPs exhibited a particle size between 60 and 100 nm and did not show toxicity at the evaluated concentrations. In cellular viral infection models against Zika virus (ZIKV), Junín virus (JUNV), vesicular stomatitis virus (VSV) and herpes simplex virus (HSV-1), the BSA-based NPs loaded with MPA or RBV demonstrated antiviral properties superior to those of non-encapsulated agents, as well as 100- and 200-fold effective dose reductions, respectively. These findings clearly indicate the potential of BSA NPs as a novel platform for the development of safer and more efficient antiviral therapies.
Application of the Probability of Extreme Sea Levels at Selected Baltic Sea Tide Gauge Stations
Authors: Wolski Tomasz , Giza Andrzej , Wiśniewski Bernard
Published: January 2025

The aim of this study was to analyze the application of the probability of extreme water level predictions along the entire Baltic Sea coast. In the initial part of this work, the critical sea levels off the Baltic States were reviewed. These levels are related to the height of the breakwaters and were determined on the basis of probabilistic methods. Then, the heights of the theoretical water levels in the entire quantile range were determined. Calculations were performed using Gumbel and Pearson III type distributions. Visualizations of the theoretical maximum and minimum water levels, as well as calculations related to the sea surface and length of the coastline, were made using ArcGIS 10.2.1 software. A comparison of theoretical water levels from two periods showed that over the last 60 years, there has been a stable trend of an increase in both the theoretical and observed maximum water levels of 2.6 mm/year. At the same time, the return period for the Baltic tide gauge stations was reduced by an average of about 50%. It could thus be concluded that hydrological hazards in the Baltic Sea region appeared twice as often as they did in the first half of the 20th century. Later in this work, we determined what size of the sea surface and the coastline length corresponded to particular sea level ranges for different return periods. For the maximum theoretical water with a 200-year return period, as much as 19.1% of the Baltic Sea surface and 23.8% of its coastline length may be influenced by extremely high sea levels (≥200 cm). These are areas in the inner parts of the great Baltic gulfs. For them, critical water levels are lower than 200 cm, which indicates a potential risk of storm floods. Based on probability calculations, it could be concluded that Pärnu Bay, within which lies the Pärnu tide gauge station, is the most hydrologically dangerous basin in the Baltic Sea.
Colonizing the Anthropocene Refugia? Human Settlements Within and Around Wild Protected Areas in Southern Chile
Authors: Ospina Guillermo
Published: January 2025

Colonization of the “remnants of the natural world” or “last wild spaces” is a process that continues at the present time. This colonization is mainly happening in unprotected spaces outside the global protected area network but is sometimes also attracted by natural resources near or within these “Anthropocene refugia”. Critical perspectives consider that protection measures keeping people far away do not guarantee the saving of wild nature but are another way to colonize it under the neoliberal imperative. This article essays an image composition based on available explicit spatial data from public sources as a representation of human settlement distribution within and around (buffer zone) the Wild Protected Areas System in Southern Chile. From an interpretative perspective beyond the dichotomic framework of pristine wilderness versus anthropogenic pressures, this article explores patterns configurating complex assemblages with diffuse limits which challenge the mainstream conservation model adopted by the State, in which people remain invisible, to think about human activity within protected areas and the unprotected space around them in a different way. In conclusion, the current system of protected areas, by itself, is not sufficient to maintain diversity, while the change processes driven by neoliberal exploitation remain within a framework dominated by political economy. New directions in interdisciplinary research and policy interactions must be explored to develop innovative measures, such as the idea of refugia against the demands of the Anthropocene.
Nível de conhecimento tático declarativo nas MEC: uma revisão integrativa
Authors: Silva Luvanor Santana da , Santana Diogo Ferreira de , Leão Iberê Caldas Souza
Published: January 2025

Introdução. Na prática das modalidades esportivas coletivas (MEC), o atleta necessita de uma boa compreensão sobre o jogo. Durante o mesmo, processos cognitivos como atenção, concentração e tomada de decisão, são importantes para o atleta ter sucesso na competição. Objetivo. Analisar e discutir o nível de Conhecimento Tático Declarativo (CTD) de atletas de basquete, futsal, handebol e voleibol. Método. Utilizou-se as bases de dados PubMed, Science Direct, BVS (Biblioteca Virtual em Saúde), Google Acadêmico, SportsDiscus e SciELO, nos últimos 20 anos. Resultados. Encontrou-se 1.794 artigos e documentos, sendo que, 27 elegíveis. Foi visto 44,44% com atletas masculino, 33,33% com atletas feminino e 18,51% com atletas (masculino/feminino), (33,34%) voleibol, (25,93%) handebol, (29,62%) futsal e (11,11%) basquetebol. O nível de CTD apresentou-se como uma variável importante para o atleta/praticante. Conclusão, O CTD pode influenciar na compreensão do jogo e na tomada de decisão.
Les rythmes de la fête au Moyen Âge
Authors: Schmitt Jean-Claude
Published: January 2025

Après un rapide bilan des études sociologiques, anthropologiques et historiques concernant la fête (entendue au sens le plus large possible de toutes les manifestations portant en latin ou dans une langue vernaculaire le nom de «fête »), l’article propose de partir, de manière régressive, de la critique révolutionnaire – en 1789 – du rythme des fêtes d’Ancien Régime (Mona Ozouf) pour n’en venir qu’ensuite aux fêtes médiévales de toutes sortes, liturgiques, mais aussi princières ou villageoises. Les rythmes festifs ont pour caractéristiques la périodicité et aussi la variation (voire l’arythmie), en évitant toujours la simple répétition. Cette observation vaut autant pour la succession des fêtes dans le cycle de l’année que pour le déroulement de chaque fête dans sa durée propre. L’inventaire des fêtes étant par nature infini, l’étude se concentre sur un nombre limité d’exemples, notamment les fêtes de bachellerie étudiées naguère par Nicole Pellegrin ou plus récemment les fêtes médiévales (de France, Italie, Allemagne, Espagne) analysées dans un numéro spécial de la revue Questes.
Les enjeux socio-économiques des jours fériés à la fin du Moyen Âge : l’exemple d’un procès au Parlement de Paris entre la ville et le chapitre de Saint-Quentin
Authors: Hamel Sébastien
Published: January 2025

Du lundi 30 décembre 1443 au jeudi 30 janvier 1444 se tient au Parlement de Paris un procès opposant le maire, les jurés et les échevins au doyen et au chapitre collégial de la ville de Saint-Quentin. L’enjeu est de déterminer laquelle des deux parties a le droit de réglementer le commerce et le travail lors des jours fériés. Les prémisses de ce procès permettent d’illustrer le problème de façon concrète, principalement en le quantifiant, c’est-à-dire en mesurant l’incidence des jours fériés sur la vie économique de la ville de Saint-Quentin.
A Case of Mistaken Identity: An Ink Chrysanthemums Painting Attributed to Xiang Shengmo (1597–1658) and its Historical Significance
Authors: Bianchi Alice
Published: January 2025

Cet article est consacré à un rouleau horizontal représentant des chrysanthèmes à l’encre, attribué au peintre Xiang Shengmo (1597-1658) et réalisé pour Yu Junshen (1628-après 1697), collectionneur fukiénais résidant à Nankin, où s’étaient réfugiés nombre de loyalistes Ming (yimin) dans la deuxième moitié du XVIIe siècle. Après avoir analysé les différents éléments qui remettent en cause l’attribution actuelle à Xiang Shengmo et proposé de réattribuer cette peinture à un maître moins célèbre de l’époque, l’article met en lumière le contexte très particulier de sa création à travers une interprétation de ses motifs picturaux ainsi qu’une étude détaillée d’une partie de ses colophons composés par des loyalistes célèbres de l’époque, permettant d’examiner leurs réactions face à la transition dynastique. En conclusion, bien qu’il ne s’agisse pas d’une œuvre de Xiang Shengmo, l’article montre que cette peinture n’en est pas moins importante, emblématique du moment charnière où la communauté yimin de Nanjing passa d’une résistance active à la nouvelle dynastie Qing à une forme de résistance passive, en se retirant de la vie politique et sociale.
Saint-Martial de Limoges, l’abbatiale du Sauveur. Le chevet roman d’après les textes et la documentation graphique
Authors: Vergnolle Éliane
Published: January 2025

Der Verlust der romanischen Abteikirche Sankt Salvator, zwischen 1791 und 1807, beraubt uns eines erstrangigen Baudenkmals des 11. Jhs. Verschiedene Texte geben indessen Auskunft über ihre Baugeschichte und eine bemerkenswerte Sammlung von Plänen und Zeichnungen des 18. Jhs. ermöglicht uns, ihre Baugestalt annäherungsweise nachzuzeichnen. Unser Kenntnisstand wurde aufgrund von Grabungen zwischen 2014 und 2016 grundlegend erneuert, die Substrukturen eines Umgangschores mit Kapellenkranz offengelegt haben, die 1017-1018 im Bau waren und 1028 geweiht wurden. Eine Analyse der graphischen Dokumentation, gekreuzt mit den Schriftquellen führt zu der Annahme, dass nach dem Brand von 1043 die Ostteile durch umfangreiche Bauarbeiten erneuert wurden, die 1063 mit der von Abt Odolric (1025-1040) beauftragten Aufstellung der Altarmensa aus weißem Marmor beendet waren. Zu diesem Zeitpunkt waren die drei östlichen Langhausjoche, die zum Chor der Mönche gehörten, zweifellos vollendet. Das Langhaus wurde vom cluniazensischen Abt Adémar de Laurière (1063-1084) vollendet, der auch ein Ensemble Wandmalereien in Auftrag gab. Dagegen gibt kein Text Auskunft über den Vorhallenturm am Eingang der Abteikirche, der lediglich durch eine alte graphische Dokumentation bekannt ist.
Saint-Martial de Limoges. L’apport des fouilles à la connaissance de l’abbatiale du Sauveur
Authors: Lhermite Xavier , Marty Angélique
Published: January 2025

Following surveys carried out in 2014, an archaeological research programme was undertaken on the Saint-Martial site in 2015 and 2016. The excavation sought to discover vestiges of the abbey church that could be used in a valorization of the site. The investigations revealed a previously unknown early medieval church. Despite the very partial state of conservation of the first phases of the abbey, their early date and quality raise questions about the origins of the religious institution and about the possible part played by the Carolingian sovereigns in its development. The rediscovery of the great Romanesque abbey church of the Saviour was fully expected, but the vestiges brought to light both the quality of the design of the chevet and the extremely careful preparation of the foundation walls, with a fine revetment several meters high. It also opened up new questions about the plan and disposition of the edifice, which is largely tributary to pre-existing buildings.
Adémar de Chabannes et l’apostolicité de saint Martial : pèlerinage, liturgie et architecture à l’approche du millénaire de la passion
Authors: Landes Richard
Published: January 2025

Der vorliegende Essay untersucht eine enthusiastische christliche Volksbewegung und ihre Rolle beim Bau der neuen Abteikirche Sankt Salvator in Sankt Martial von Limoges in den 1020er Jahren. Die ersten Erscheinungsformen dieser Religiosität waren die Gottesfriedensversammlungen in den Jahren 990-1030 ; Pilgermassen eilten durch das Land, die Heiligenverehrung und damit verbundene Liturgien wurden initiiert oder neu belebt und schließlich verbreiteten sich ikonoklastische „Häresien“ im einfachen Volk, die die Kirche und ihre Liturgie ablehnten. In Limoges flammte bei einer Gottesfriedensversammlung 994 der Kult um Sankt Martial auf und von nun an eilten alljährlich in der Fastenzeit Scharen von Pilgern herbei. 1018 wurde die Menge zu Tode getrampelt ; nach Ansicht Adémars de Chabannes bestärkte dieses Ereignis anti-kirchliche Bewegungen. In diesem Schmelztiegel im Limoges der 20er Jahre des neuen Jahrhunderts wurde der Bau einer neuen Kirche maiori amplitude in Angriff genommen, deren Grundriss auf die Aufnahme der Pilgerscharen zugeschnitten war. Die neue Architektur gewährte Laien, einfachen Leuten aus dem Volk, Männern und Frauen einen bis dahin nie dagewesenen Zugang. Mit den großen Pilgerkirchen eröffnete sich für die Pilger ein neues Zeitalter, in dem neue religiöse, ökonomische, soziale und intellektuelle Bewegungen entstanden.
Techniques constructives du XIe siècle. L’exemple du Val de Loire
Authors: Prigent Daniel
Published: January 2025

Since the mid-1980s, following in-depth studies of Romanesque buildings, occasionally benefitting with objective dating, the number of edifices attributable to the eleventh century in the Loire Valley has grown considerably. Among the characteristics now taken into account, those concerning the use of materials have clarified certain aspects of the evolution of construction techniques. In the continuation of earlier practices, rubble masonry is dominant at the start of the century. The stones, regularly set and of similar size, are progressively replace by elements of irregular volume. Other, less representative types of revetment (decorative, composite, mixed, etc.) also continue to be used. But the eleventh century sees an ample development of cut stone, sometimes associated in the early decades with a revetment of regular rubble stones of homogeneous size. The cut stone adopts, after a few precursors from the ninth and tenth centuries, a veritable standardization of height, leading to a perceptible improvement in the functioning of the worksite. The length of the stones follows a single module distribution, but sometimes bi-module. The dressing of the stones with a straight cutting hammer, rough, often irregular, evolves in the last decades into a more careful treatment.
Les hôtels gothiques nantais
Authors: Charrier Lény
Published: January 2025

Cet article condense les résultats obtenus lors de notre thèse de doctorat sur les hôtels particuliers de Nantes à la fin du Moyen Âge. Il met en avant l’implantation du duc et de sa cour à Nantes de manière pérenne et dont la présence a favorisé l’émergence d’une architecture édilitaire. Partant de ce constat, il montre les relations de ces dignitaires avec le pouvoir ducal puis avec l’autorité royale. Cet article analyse également les caractéristiques architecturales de ces hôtels et le mode de vie de leurs habitants afin de définir ce qu’est un hôtel nantais. Enfin, par l’intermédiaire de leur typologie et de leur décor, il montre les influences qui les unissent en faisant ressortir leurs traits communs et leurs particularismes tout en les mettant en perspective avec les édifices bretons et ceux du Val de Loire. Cela dans le but de faire valoir les mécanismes qui ont, semble-t-il, permis à Nantes d’être la première place du duché, offrant ainsi au duc la possibilité de rivaliser avec le roi de France.
الدوائر الإقليمية والدولية للسياسة الخارجية الجزائرية (الإنتشار، الأداء والتأثير)
Authors: BOUKARRAS Roukaia
Published: January 2025

تتفاعل السياسة الخارجية الجزائرية ضمن الدوائر الإقليمية والدولية التي تنتمي إليها: تتأثر بها، وتؤثر فيها؛ ضمن علاقة اعتماد متبادل إقليمية، تسعى خلالها إلى لعب دور قوة إقليمية مؤثرة. لكنها تواجه تحديات عديدة ناتجة عن التنافس المتزايد والضغوطات التي تعيشها المناطق التي تشكل عمقا استراتيجيا ومجالا حيويا للجزائر.  من ذلك يسعى صانع القرار الجزائري إلى تبني استراتيجية شاملة ومتكيفة تعزز تأثيرها وأدائها وتزيد من انتشارها؛ عن طريق اعتماد دبلوماسية استباقية وحركية تؤكد العقيدة الراسخة، التي تجسدت في موقفها الثابت من القضية الفلسطينية وحركات التحرر والقضايا العادلة، ورغبتها في احياء التعاون البيني في المنطقة المغاربية، والتي دعمت بانتخابها كعضو غير دائم في مجلس الأمن الدولي الى غاية ديسمبر 2025، وهو ما جعلها لاعبا محوريا في المشهد المحلي والدولي. تعمل الجزائر من اجل الوصول إلى تحقيق تموقع قوي في الأقاليم الفرعية التي تنتمي اليها بتعزيز دورها كوسيط موثوق في قضايا الشرق الأوسط، والتركيز على دفع علاقاتها مع الدول العربية (والمغاربية) والمتوسطية والإفريقية من خلال حلول أكثر ابتكارا؛ خاصة وإنها تملك عناصر القوة الكامنة من طاقة واقتصاد وديموغرافيا الى جانب الإرادة السياسية القوية.
Adesão à assistência fisioterapêutica em pacientes com fixação proximal de fêmur
Authors: Sobral Tayná de Oliveira , Vaceli José Vinicius de Souza , Ferreira Murilo David , Andrade Jessyca Alves de , Costa Angelo Ferreira Meireles da , Santos Danilo Rodrigues dos , Rodrigues Daniele Sanches , Oliveira Amanda Aparecida Cruz
Published: January 2025

Introdução: A fratura de fêmur está entre as lesões traumáticas mais frequentes em adultos mais velhos, sendo a fratura proximal o tipo mais comum, classificada em intracapsular ou extracapsular. O mecanismo de lesão está associado a quedas da própria altura, levando a perda da funcionalidade e independência. Desta forma, a fisioterapia atua diretamente na reabilitação desses pacientes. Objetivo: Avaliar a funcionalidade e caracterizar se há ou não adesão à assistência fisioterapêutica pós alta hospitalar. Metodologia: Foi realizado um estudo do tipo ensaio clínico randomizado, retrospectivo, com análise de prontuários de pacientes internados na enfermaria ortopédica do Hospital de Base de São José do Rio Preto - SP, entre setembro e novembro de 2024. Resultados: Após a análise de 21 prontuário, perante o teste-t, obteve-se correlação entre a escala de Johns Hopkins no momento da alta hospitalar com a mesma escala no momento após a alta, foi analisado e identificado um valor de Tc: 1,725, com confiabilidade de 95% de que não houve uma piora estatisticamente significativa entre o momento da alta com o pós alta pela escala de funcionalidade.Conclusão: Conclui-se que os pacientes não obtiveram uma diferença estatisticamente significante entre o momento da alta hospitalar com o momento pós alta, não sendo encontrado uma piora e nem melhora da funcionalidade após o período de internação, além disso, a maioria dos pacientes apresentaram adesão fisioterapêutica após a alta hospitalar.
Repercussões do transtorno do estresse pós-traumático em vítimas de abuso sexual infantil
Authors: Caneschi Gian Lucas Teixeira , Miranda Carolina Silva , Gama Jairo Roberto de Almeida
Published: January 2025

Introdução:  O abuso sexual infantil (ASI) é um problema altamente prevalente em todo o mundo, com taxas variando entre 8 e 31% para mulheres e 3 e 7% para homens1. Tal evento traumático é capaz de gerar repercussões físicas, emocionais, cognitivas e comportamentais negativas a curto e a longo prazo2. O TEPT está entre os sintomas mais frequentemente relatados pelas vítimas, sendo caracterizado pela revivência do trauma, alterações de cognição, de humor e evitação de experiências relacionadas ao trauma1. Objetivos: Analisar as implicações do TEPT em vítimas de abuso sexual infantil, no âmbito do desenvolvimento neuropsicológico, cognitivo e comportamental a longo prazo. Métodos: Revisão  integrativa  da  literatura  sobre transtorno do estresse pós-traumatico em vitimas de abuso sexual infantil. Foram  analisados ensaios clínicos e estudos observacionais publicados originalmente em inglês, dos últimos 11 anos, tendo como referência as bases de dados MedLine e Scielo. Os descritores utilizados foram: Post-Traumatic Stress Disorders; Sexual Child Abuse; Sexual Trauma; Sex Offenses. Resultados: O abuso sexual infantil impacta o desenvolvimento neuropsicológico, cognitivo e comportamental, agravado pela ausência de apoio social. Além disso, fatores como idade, proximidade com o agressor e autoculpa têm forte influência no desenvolvimento do TEPT. Suporte social e intervenções precoces mostraram-se capazes de reduzir os danos da experiência traumática. Conclusão: O TEPT pode estar associado a variadas manifestações nocivas a longo prazo, tais como autoculpa e dificuldade de reconhecimento e de demonstração de afeto. A complexidade desse cenário leva à necessidade de uma abordagem terapêutica individualizada.
Beneficios del probiótico local vs la terapia con antibióticos sistémicos en el tratamiento no quirúrgico en la periodontitis
Authors: Enríquez Cristian David Pesantez , Ortega Jonathan Joao Veliz , Muñoz Priscila Fernández , Aguilera Diego Xavier Toral
Published: January 2025

La periodontitis es una enfermedad inflamatoria crónica que afecta los tejidos que rodean y soportan los dientes; el tratamiento no quirúrgico tradicionalmente incluye la terapia con antibióticos sistémicos que pueden asociarse con efectos adversos y resistencia bacteriana. Los probióticos locales emergen como una alternativa terapéutica potencial, ofreciendo beneficios al modular la microbiota oral sin efectos adversos. El objetivo fue evaluar la eficacia de los probióticos locales en comparación con la terapia antibiótica sistémica en el tratamiento no quirúrgico de la periodontitis en adultos. Se realizó una revisión bibliográfica mediante la selección de 40 estudios en bases de datos indexadas como PubMed, Scopus, SciELO y Web of Science, incluyendo publicaciones en inglés y español. Se establecieron criterios de inclusión para guiar una exploración meticulosa de la literatura científica. Se aplicaron filtros para garantizar la relevancia y actualidad de la información, excluyendo artículos con más de diez años de antigüedad y no redactados en inglés o español. Los estudios revisados muestran que los probióticos pueden ser efectivos en la reducción de la profundidad de sondaje y la pérdida de inserción clínica. No obstante, los antibióticos fueron más efectivos en reducir el índice de placa e índice gingival. La combinación de probióticos y antibióticos demostró ser superior al uso individual. Se concluyó que los probióticos locales son una alternativa viable y segura a los antibióticos sistémicos, aunque su eficacia varía. Nuevos estudios son necesarios para determinar su uso óptimo en el tratamiento periodontal.
Perspectiva discente do estágio extracurricular como complemento crucial da aprendizagem teórica e desenvolvimento de habilidades na formação médica de ensino tradicional
Authors: Queiroz Bruno Dias , Sant'Anna Tatiani Almeida Louzado , Vicópulos Isabela Matos , Rosa Anna Carolina da
Published: January 2025

Com o crescente número de formandos na área da saúde, bem como o aumento da abertura de faculdades que oferecem o curso de Medicina, as discussões sobre métodos eficazes de ensino se tornam cada vez mais relevante. O objetivo deste trabalho é de narrar a experiência discente de um estágio extracurricular hospitalar e discutir a importância da proatividade no processo de aprendizagem médica.  Aliado a literatura, o embasamento do texto foi feito com busca de artigos nas bases de dados Biblioteca Virtual de Saúde, Scielo e PubMed. Este estudo conclui como benéfica, apesar de insuficiente por si só, a aprendizagem ativa na formação do profissional de saúde, tanto em aspectos acadêmicos como psicológicos.
Abordagem cirúrgica na pancreatite biliar: o papel da colecistectomia
Authors: Stuczynski Eduardo Vettorazzi , Nepomuceno Gabriela Lima Mendes , Tedd Rosana da Costa Figueiredo Gabriel , Filho Carlos Alberto de Oliveira , Araújo Giovanna Crevelaro , Fazan Valéria Paula Sassoli , Caro Jaime Javier Garcia , Silva Jéssica de Jesus , Verolese Andressa Maffei , Ronchi Maristela Stockl , Pereira Clara Inês Mesquita
Published: January 2025

A pancreatite aguda é caracterizada por uma inflamação súbita do pâncreas, com sintomas de início rápido. Nos Estados Unidos, cerca de 270 mil casos são registrados anualmente, sendo essa a principal causa de internações hospitalares relacionadas ao trato gastrointestinal. No Brasil, é a quinta maior causa de mortalidade entre as doenças gastrointestinais. A principal origem da pancreatite aguda é a colelitíase, que responde por 40% a 65% dos casos. O manejo desses pacientes inclui a realização de colecistectomia, que pode ser precoce ou eletiva, dependendo da gravidade do quadro. Este estudo teve como objetivo comparar os resultados da colecistectomia precoce e eletiva em pacientes com pancreatite aguda causada por cálculos biliares. A pesquisa foi conduzida por meio de uma revisão de literatura, em que inicialmente foram selecionados 27 artigos, dos quais 16 atenderam aos critérios definidos. Após a análise, concluiu-se que a colecistectomia precoce é indicada para casos leves de pancreatite aguda biliar, enquanto a abordagem eletiva é mais apropriada para pacientes com quadros moderados a graves.
Manual técnico: mormo ou lamparão, uma doença infectocontagiosa
Authors: Pinto Pedro Henrique Damasceno , Moura Marielly Maria Almeida , Ribeiro Joyce Costa , Santos Leandra Cristina Soares , Dias Wlly Polliana Antunes , Castro Sabrina Gonçalves Vieira de , Coutinho Juddy de Souza , Lopes Maria Eduarda Ramalho , Santos Jaine Aparecida dos , Gitirana Ruanna Rosa , Versiani Ana Ariela Gusmão , Sousa Irisléia Pereira Soares de , Matos Amanda Dayanne Malta , Lopes Isadora Leite e , Lima Maria Clara Chaves , Fernandes Álvaro Henrique Lopes , Dias Júnior Carlos Antônio , Alves Nysa Neves
Published: January 2025

O mormo é uma doença infecto-contagiosa grave causada pela bactéria Burkholderia mallei, que afeta equídeos e é zoonótica, com alta letalidade em humanos. A transmissão ocorre por contato com secreções infectadas, ingestão ou inalação, sendo favorecida por manejo inadequado. Clinicamente, apresenta formas nasal (secreção purulenta e úlceras), pulmonar (tosse, febre e lesões pulmonares) e cutânea (nódulos ulcerados e linfangite). Em humanos, varia de febre e lesões cutâneas a insuficiência multiorgânica na forma septicêmica.O diagnóstico combina exames clínicos, PCR e sorologia. No Brasil, equídeos infectados são eutanasiados, e o controle depende de quarentena, desinfecção e manejo rigoroso. Em humanos, o tratamento inclui antibióticos como ceftazidima, imipenem ou doxiciclina, além de suporte clínico para formas graves. A prevenção do mormo baseia-se em medidas sanitárias, como triagem sorológica, isolamento de animais suspeitos, controle de movimentação, desinfecção de ambientes e conscientização dos criadores. Não há vacina disponível, e a erradicação depende de vigilância epidemiológica e notificação compulsória dos casos. A gravidade da doença reforça a necessidade de manejo adequado e protocolos preventivos rigorosos para proteger tanto os animais quanto os seres humanos.
MODEL OF A DEMONSTRATION EXAM IN THE DISCIPLINES OF PRESCHOOL EDUCATION PROFILE
Authors: Krotova T.V. , Nikiforova O.V. , Gaidukova K.O.
Published: January 2025

The article considers the demonstration exam as a form of intermediate certification. A review of research in this area has been conducted. A model of a professional (demonstration) exam as a form of intermediate certification in the discipline of the core of pedagogical education is presented using the example of the discipline “Creating a developing subject-spatial environment in a preschool educational organization” for future preschool education teachers, developed by the author’s team of the Faculty of Preschool Pedagogy and Psychology of Moscow Pedagogical State University.
О МОДЕЛЯХ ЦЕНТРАЛИЗАЦИИ И ДЕЦЕНТРАЛИЗАЦИИ УПРАВЛЕНИЯ В ЦИФРОВОМ ОБЩЕСТВЕ
Authors: Ф.И. Ерешко , М.А. Горелов
Published: January 2025

В работе обсуждается ситуация, сложившаяся в теории управления в связи с активным развитием идей цифровизации общества. Наиболее ярко публицистически трансформация общества представлена в книге-манифесте К. Шваба «Четвертая промышленная революция». Приводится описание позиции и проектов отечественных ученых. Рассмотрен проект Биткоин как текущий социально-экономический эксперимент, а в связи с ним - ряд теоретико-игровых моделей. Рассмотрена серия линейных моделей принятия решений, приводятся некоторые формальные результаты о соотнесении централизации и децентрализации в общем нелинейном случае.

In article the situation which has developed in the theory of management in connection with active development of the ideas of digitalization of society is considered. Most brightly publicistic transformation of society is presented in the book manifesto by K. Schwab «The fourth industrial revolution». The description of a position and projects of domestic scientists is provided. The Bitcoin project as the current social and economic experiment, and communications with him a number of game-theoretic models is considered. A series of linear models of decision-making is considered, some formal results about correlation of centralization and decentralization are given in the general nonlinear case.
ПЕРСПЕКТИВА РАЗВИТИЯ ГЛОБАЛЬНОЙ КОСМИЧЕСКОЙ ИНФОРМАЦИОННОЙ СИСТЕМЫ РЕАЛЬНОГО ВРЕМЕНИ ДЛЯ РЕШЕНИЯ ЗАДАЧ ЦИФРОВОЙ ЭКОНОМИКИ РОССИИ
Authors: А.И. Галькевич
Published: January 2025

В статье предлагается глобальная космическая информационная система на базе космических информационных узлов из малых космических аппаратов (МКА), объединенных в единое цифровое информационное поле (космическая шина). Целью создания системы является обеспечение глобальности, непрерывности, оперативности и живучести кластеров космических систем. Обосновываются актуальность создания системы. Описано современное состояние исследований по этому направлению. Показаны технологии, которые необходимо отработать для практической реализации системы. Оценена эффективность и конкурентоспособность системы.

The article proposes a global space information system based on space information nodes from small spacecrafts (MCAs), united in a single digital information field (space bus). The goal of the system is to ensure the globality, continuity, efficiency and survivability of clusters of space systems. The urgency of creating a system is justified. A modern state of research in this area is described. Technologies are shown that need to be worked out for practical implementation of the system. The efficiency and competitiveness of the system is assessed.
ИСПОЛЬЗОВАНИЕ ОНТОЛОГИЙ В КОРПОРАТИВНЫХ АВТОМАТИЗИРОВАННЫХ СИСТЕМАХ
Authors: С.В. Горшков
Published: January 2025

Любая крупная организация накапливает огромное количество информации в информационных системах, автоматизирующих ее деятельность. Как правило, данные в разных системах структурированы без единой концепции, слабо связаны, плохо поддаются поиску и использованию вне заранее предусмотренных рутинных бизнес-процессов. В результате накопленная информация становится неэффективно используемым активом, на поддержку которого тратятся значительные средства, но который приносит довольно ограниченную выгоду. Потенциал использования этой информации огромен, но для его раскрытия необходимо не часто встречающееся на практике сочетание управленческой воли и мотивации, видения ИТ-архитектуры и адекватных технологических средств с возможностью воплотить в жизнь амбициозный проект.

Any organization accumulates a huge number of information in the information systems automating her activity. As a rule, data in different systems are structured without uniform concept, poorly connected, badly give in to search and use out of in advance provided routine business processes. As a result the saved-up information becomes inefficiently used asset for which support considerable means, but which brings quite limited benefit are spent. Potential of use of this information is huge, but his disclosure requires the combination of administrative will and motivation, vision of IT architecture and adequate technological means to an opportunity which isnt often found in practice to realize the ambitious project.
РОКОВОЙ БИТКОИН
Authors: И.В. Неволин
Published: January 2025

Энтузиасты криптовалюты гордятся ее децентрализованным характером и противятся попыткам регулирования со стороны национальных ведомств. Последние, кстати, не всегда способны четко сформулировать свою позицию. Тем интереснее читать документы, в которых это удается. В докладе ФРС США (Mills et al, 2016) явно читается негативный настрой к P2P проектам по блокчейн из-за отсутствия в них возможности удовлетворить ряд требований, в том числе, нормы по борьбе с отмыванием денег. По мнению авторов, если блокчейн имеет шансы на успех в построении платежной системы, он должен объединять исключительно финансовые организации, каждая из которых регулируется соответствующим образом. Решения этого идейного противоречия - транзакций между организациями, а не гражданами напрямую - пока не предвидится.

Cryptocurrency enthusiasts are proud of its decentralized nature and oppose attempts at regulation by national authorities. The latter, incidentally, are not always able to articulate their position. Its interesting to read the documents in which it is possible. The report of the US Federal reserve (Mills et al, 2016) clearly reads the negative attitude to p2p projects on blockchain due to the lack of opportunities in them to meet many requirements including norms against money laundering. According to the authors if the blockchain has a chance of success in the construction of the payment system it should unite exclusively financial organizations each of which is regulated by the relevant industry. Solutions to this ideological contradiction-transactions between organizations not citizens directly is not yet expected.
ВОЗМОЖНЫЕ ОБЩИЕ ПОДХОДЫ К РЕАЛИЗАЦИИ СИСТЕМЫ ОЦЕНКИ ПЕРСОНАЛА В ИССЛЕДОВАТЕЛЬСКОЙ ОРГАНИЗАЦИИ
Authors: А.А. Белянов
Published: January 2025

Обсуждаются методы сетевого анализа и источники данных для расчёта индивидуального рейтинга сотрудников в исследовательской организации. В том числе упомянуты библиометрические показатели и граф корпоративных коммуникаций.

The paper discusses methods of network analysis as well as data sources for the personal rating calculation in the research organization. Bibliometric indicators and graph of corporate communications are also in focus of our analysis.
ЗАЧЕМ НАМ ВООБЩЕ ЗАМЕЩАТЬ “УСЛОВНЫЙ ORACLE”
Authors: А.Н Прохоров
Published: January 2025

В статье идет речь о возможностях и целесообразности импортозамещения западных СУБД на российском рынке, о роли Open Source в этом процессе. Известно, что в реестре отечественного софта львиную долю занимает прикладное ПО, и подчас импортозамещение касается в основном так называемой «видимой части айсберга», - прикладного ПО, оставляя без должного внимания другие слои технологического стека. Очевидно, что серьезное импортозамещение невозможно без замещения системного ПО и, в частности, продуктов класса СУБД. Насколько это возможно и оправдано? Полемика на данную тему представляет определенный интерес.

The article deals with the possibilities and feasibility of import substitution of Western DBMS in the Russian market, the role of Open Source in this process. It is known that in the Russian software market the lions share is occupied by applied SOFTWARE, and sometimes port substitution concerns mainly the so-called visible part of the iceberg-applied SOFTWARE, leaving other layers of the technological stage without due attention. It is obvious that serious import substitution is impossible without replacement of system SOFTWARE and, in particular, products of DBMS class. As far as possible and justified The controversy on this topic is of some interest.
ЦИФРОВАЯ ТРАНСФОРМАЦИЯ РЫНОЧНЫХ ИНСТИТУТОВ
Authors: А.Н. Козырев
Published: January 2025

В статье показано, как все более широкое проникновение цифровых технологий в различные сферы жизни приводит к необходимости изменений целого ряда институтов, прежде всего, экономических институтов, обеспечивающих функционирование рыночной экономики. Институты здесь понимаются предельно конкретно, как их понимают юристы, что позволяет обсуждать их изменения предметно, апеллируя к изменениям в законодательстве или судебным решениям, и соотносить эти изменения с техническими достижениями в сфере технологий.

The article shows how the increasing penetration of digital technologies in various spheres of life leads to the need to change a number of institutions, especially economic institutions that ensure the functioning of the market economy. Institutions here are understood very specifically, as lawyers understand them, which allows to discuss their changes in detail, appealing to changes in legislation or judicial decisions, and to correlate these changes with technical achievements in the field of technology.