bluuebunny/crossref_metadata_2025 huggingface dataset:
Critical point approaches to nonlinear square root Laplacian equations
Authors: Bohner Martin , Caristi Giuseppe , Heidarkhani Shapour , Salari Amjad
Published: May 2024

This work is devoted to the study of multiplicity results of solutions for a class of nonlinear equations involving the square root of the Laplacian. Indeed, we will use variational methods for smooth functionals, defined on reflexive Banach spaces, in order to achieve the existence of at least three solutions for the equations. Moreover, assuming that the nonlinear terms are nonnegative, we will prove that the solutions are nonnegative. Finally, by presenting an example, we will ensure the applicability of our results.
On n-1-absorbing primary ideals
Authors: Ulucak Gulsen , Babaei Sakineh , Sevim Esra Sengelen
Published: May 2024

The paper aims to present a new primary ideal in a commutative ring R with nonzero identity element. We introduce the new primary ideal as an n-1-absorbing primary ideal that is a generalization of both primary and 1-absorbing primary ideals. We propose to achieve two goals with this paper. Firstly, we study and characterize some essential properties of an n-1-absorbing primary ideals and figure out the relations between the other types of ideals such as prime, 1-absorbing primary and irreducible ideals. Then, we classify some special rings that admit an n-1-absorbing primary ideal. We provide the results by introducing some examples.
On models of the Lie algebra K 5 and Lauricella functions using an integral transformation
Authors: Kapoor Ayushi , Sahai Vivek
Published: May 2024

We construct new (n + 1)-variable models of irreducible representations of the Lie algebra K 5. An n-fold integral transformation is used to obtain a new set of models of K 5 in terms of difference-differential operators. These models are further exploited to obtain recurrence relations, generating functions and addition theorems.
On a sequence of rational numbers with unusual divisibility by a power of 2
Authors: Dubickas Artūras
Published: May 2024

In this note we consider the sequence of rational numbersbn=∑k=1n2k∕k. We show that the power of2in the expansion ofbnis unusually large, at leastn+1−log2(n+1), and that this bound is best possible. The sequencebn,n=1,2,3,…, is related to the sequence A0031449 in the On-Line Encyclopedia of Integer Sequences.
Existence and multiplicity of solutions for a p(x)-Kirchhoff type equation with Steklov boundary
Authors: Yücedag Zehra
Published: May 2024

In this paper we study a class of p (x)-Kirchhoff type problem with Steklov boundary value in variable exponent Sobolev spaces. Precisely, we show the existence of at least three solutions and a nontrivial weak solution.
M-Srivastava hypergeometric functions: integral representations and solution of fractional differential equations
Authors: Ata Enes
Published: May 2024

In this paper, we introduce a new extensions of Srivastava’s triple hypergeometric functions HA, HB and HC, by using an modified beta function, which given with a generalized M-series in its kernel. We also introduce a new extension of Appell’s hypergeometric function of the first kind by using the same modified beta function. Furthermore, we give some integral representations of the new extensions of Srivastava’s triple hypergeometric functions. Finally, we obtain solutions of fractional differential equations involving new extensions of Srivastava’s triple hypergeometric functions.
The density of tuples restricted by relativelyr-prime conditions
Authors: Sittinger Brian D. , Chen Vickie V.
Published: May 2024

In order to considerj-wise relativer-primality conditions that do not necessarily require allj-tuples of elements in a Dedekind domain to be relativelyr-prime, we define the notion ofj-wise relativer-primality with respect to a fixedj-uniform hypergraphH. This allows us to provide further generalisations to several results on natural densities not only for a ring of algebraic integersO, but also for the ringFq[x].
A polynomial system of degree four with an invariant triangle containing at least four small amplitude limit cycles
Authors: Szántó Iván
Published: May 2024

In this work, the existence of a polynomial system of degree four with an invariant triangle containing at least four small-amplitude limit cycles is proved. This result improves the result obtained in [2].
Note on blow up solutions for a general class of semilinear parabolic equations involving second order operator
Authors: Bousgheiri Abdelhak , Ourraoui Anass
Published: May 2024

This work deals with an initial-boundary value problem of Laplacian parabolic equation (h(u))t + △pu = f(u(x,t)),inΩ × (0,∞), u(x,t) = 0,on∂Ω × (0,∞), u(x0) = u0 ≥ 0, x ∈Ω¯, where Ω is a bounded domain in RN, N ≥ 1. Our contribution is to give a new condition on nonlinearity to obtain the blow-up solutions of the above equations.
A Legendre wavelet collocation method for solving neutral delay differential equations
Authors: Ahmed Uzair , Faheem Mo , Khan Arshad , Manchanda Geetan
Published: May 2024

The Legendre wavelet based method has been employed in this paper to investigate neutral delay differential equations. The highest order derivative is approximated by Legendre wavelet using the integral operator technique. Then integrations of Legendre wavelet are used to approximate the lower order derivatives and unknown function. To get an algebraic system of linear or nonlinear equations, approximated values of unknown function and its derivatives are substituted in neutral delay differential equations. On solving the developed system, we get unknown wavelet coefficients and subsequently the approximate solution. To analyze the theoretical usability of the approach, the upper bound of error norm is established. Moreover, the theoretical results are confirmed through few numerical experiments. A comparison of the results of presented method with method available in literature is given to conclude the superiority of the proposed method.
AVANÇOS METODOLÓGICOS DOS ÚLTIMOS 10 ANOS DO CICLO DE REPRODUÇÃO HUMANA ASSISTIDA UTILIZANDO AS TÉCNICAS DE FIV E DE ICSI
Authors: De Souza Letícia Simão , Caneguim Breno Henrique
Published: May 2024

A infertilidade humana é a incapacidade da geração de uma gestação por métodos naturais dentro de 12 meses de tentativas sem a utilização de métodos contraceptivos. A reprodução humana assistida pode ser descrita como um conjunto de técnicas e procedimentos utilizados no tratamento da infertilidade. O presente trabalho apresenta dados sobre os avanços metodológicos dos ciclos de FIV (fertilização in vitro) e ICSI (injeção intracitoplasmática de espermatozoides) e a frequência de utilização das técnicas com os anos. Trata-se de uma revisão sistemática de artigos científicos de duas bases de dados (PubMed e BVS) do período de 2011 a 2021. Foram incluídos 29 artigos, sendo sua maioria encontrada no período de 2011 e 2012. A maioria das pacientes incluídas nos estudos apresentavam idade avançada. Os estudos relataram o uso de seis tipos de indutores de estimulação oocitária, sendo as gonadotrofinas recombinantes as mais utilizadas. Por outro lado, cinco tipos de indutores de maturação foram listados, mas a utilização do hCG foi predominante. Nossos achados mostraram que houve franco aumento dos números de ciclos de FIV e de ICSI entre 2011 e 2014, assim como aumentou o número de ciclos de FIV/ICSI no período de 2015 a 2019. Além disso, questões como fatores de infertilidade, tempo de experiência dos profissionais, idade dos pacientes, foram fatores abordados nos artigos. É imprescindível a continuação de estudos sobre ciclos de reprodução humana assistida, pois são através dos avanços e na melhoria dos resultados que um número de maior de pessoas é atendida, aumentando consequentemente a procura das técnicas.
GUT MICROBIOTA AND ITS EFFECTS ON METABOLIC AND NEUROLOGICAL HEALTH
Authors: Pinheiro Bruna Santana Silva , Rodrigues Julia Gonçalves , Hildebrand Letícia Beretta , Pacheco Helen Fernanda Marcelino , Lopes Beatriz Gabiatti , Dias Fernanda Carolina Ribeiro , Paiva Aline Dias , Gomes Marcos de Lucca Moreira
Published: May 2024

The human gut microbiota plays various essential roles, including protection against pathogens, intestinal function regulation, synthesis of compounds for the host, diet compound metabolism, and direct influence on host homeostasis. The composition of the microbiota is influenced by factors like diet, age, and lifestyle, with the Westernized culture being associated with harmful imbalances. Disruption of the gut microbiota has been linked to various pathological processes, from intestinal syndromes to systemic conditions like allergies, insulin resistance, and neurological alterations. Microbiota disturbances can lead to cellular changes in colorectal tissue due to metabolic, genomic, and inflammatory influences. Therapeutic interventions to modulate the gut microbiota are considered promising approaches for managing and preventing these diseases. Continuous research on the gut microbiota and its relation to human health is of utmost importance to understand the underlying mechanisms and develop specific therapeutic interventions, complementing conventional treatment approaches.
Dobro-wolność – refleksje z czasu pandemii i nie tylko – wypowiedź o charakterze autoetnograficznym
Authors: Józefowski Eugeniusz
Published: May 2024

The author of the article is a visual creator describing his creative activity during the pandemic period. He places it in the space of his previous achievements. It does so with the awareness of creating source material with the features of maximum authenticity in order to present such an autoethnographic study to other researchers. The text presents the artist’s creative process in a methodical way. The illustrations of the works are presented and a certain key to their reading is based on the extensive set of titles attached to the article.
The significance of Podcasting for EFL learning
Authors: Fachriza Aries , Virgiyanti Diska Fatima , Nuraini Eka Indah , Dipta Dinar , Luthfi Mohammad
Published: May 2024

The use of podcasts as language teaching and learning has obtained more attention today. Podcasts have been used mostly to improve students' listening skill that is proven by numerous studies to determine how podcasts might assist students in improving their listening skills. Whereas, podcasting promotes activities for the students to practice their whole English skills. This is a literature research that provides a review of podcasting to assist EFL learners in mastering English. As many as 20 articles were used as the data sources in arranging this article. The researchers searched the articles using the keywords ‘podcast’ and ‘podcasting’. The difference between this article among previous studies is the focus on the use of podcasting for EFL learnings. The previous studies mostly discussed podcasts and podcasting for improving listening ability. The review found that podcasting is an interesting medium to be used in English learning. However, several challenges arise such as lack of technological competence, lack of vocabulary and grammar, unstable internet connection, and limited facilities. Consequently, it is advised that when using podcasts, teachers give their students appropriate direction on how to maximize their potential.
The implementation of metacognitive strategies in students’ teaching practice in microteaching class
Authors: Wahyuni Hanna Irma , Kuswandono Paulus
Published: May 2024

A B S T R A C T
Microteaching classes can be a challenging area of negotiation between personal and professional values which can help and provide pre-service teachers understanding and opportunities to hone their teaching and learning process better. This research aims to identify the application of metacognitive strategies in the preparation process for teaching practice in microteaching classes, by focusing on the research questions regarding the implementation of metacognitive strategies in teaching practice exercises and students’s motivation to apply metacognitive strategies in micro-teaching classes. A qualitative case study method was used to answer these two research questions by employing purposive sampling with three participants in a micro-teaching class (semester five). The study reveals that students applied metacognitive strategies of goal-setting, planning, monitoring, and evaluating strategies to enhance their teaching practices. These strategies are influenced by internal and external motivation factors, such as intuition, personal experience, and self-awareness. Nevertheless, as this study involved a small group and did not focus on real classroom practices, future studies are suggested to involve more participants and combine methods to track both the immediate and long-term effects of using metacognitive strategies in teacher training.
EFL students’ challenges in TOEIC® updated test: listening section
Authors: Zewitra Zewitra , Purnamasari Yessy
Published: May 2024

The TOEIC® Listening and Reading Test has been updated since 2018 and has been utilized for various purposes. This present study attempts to investigate the challenges faced by EFL students in achieving certain desired scores on the TOEIC® Updated Test, particularly in the listening section. This study employed qualitative methodology and CBT (computer-based test) of TOEIC® updated test was used as the instrument. Data was taken from the test results of 52 participants who joined POLBAN’s (Politeknik Negeri Bandung) TOEIC® Preparation and Prediction for IISMA 2024 conducted in January 2024. The results reveal that in solving the listening section in the TOEIC® Updated Test, test takers encounter difficulties in 12 different targeted skills. Some targeted skills are considered more challenging than others, i.e., understanding information questions and tag questions in the listening part II and making inferences as well as understanding graphics in the listening part IV. Surprisingly, understanding graphics is one of the new types of questions in the TOEIC® Updated Test. The fruitful implications of this study, both theoretically and practically, will be further explained in this article.
Exploring the impact of time allocation on students’ writing performance: A quantitative study
Authors: Ramadhani Dwiansari
Published: May 2024

Many educational institutions have been conducting writing assessments to measure students’ ability in writing, yet little is known about whether time restriction and learning strategies are contributing factors to students’ performance. In Indonesian educational institutions, writing assessments serve as a means to measure students’ proficiency in articulating thoughts in the target language, providing teachers with insights into their linguistic ability. The objective of this study is to determine whether allocating extra time for timed academic essays will substantially enhance the quality of students' writing. Additionally, this study seeks to uncover the correlation between students' L2 learning strategies and their writing performance. This study used a quantitative design. The main instruments were questionnaires and writing tests collected at two parallel classes of a private university in Indonesia, comprising of 50 students in total as the study participants. The quantitative methods used independent t-tests and Spearman’s rho correlation to analyze the data. The result showed that time limit had a significant effect on writing performance (t(34.6)= 3.185, p= .003). Another result indicated minimal to no correlation between writing scores and autonomous learning practices. In conclusion, this study offers valuable and practical implications in the writing assessment industry that there should be a re-evaluation in the administration of writing assessment in educational institutions in Indonesia that truly reflects students’ writing ability.
La relación del empoderamiento gerencial de la mujer y los roles gerenciales en el sector de Consumo Masivo en Lima Metropolitana en el año 2023
Authors:   , Gutierrez Torres Angela , Quinto Ramírez Diana
Published: May 2024

El presente trabajo de investigación denominado “La relación del empoderamiento gerencial de la mujer y los roles gerenciales en el sector de Consumo Masivo en Lima Metropolitana en el año 2023” posee como finalidad primordial poder conocer si el empoderamiento gerencial de la mujer influye en los roles gerenciales. De esta manera, es importante mencionar que, actualmente, el Perú se encuentra ubicado en el puesto N° 66 en el ranking mundial de brecha de género, incluyendo ámbitos laborales, educación, política y salud. El presente estudio posee una división de cinco capítulos. En primer lugar, el capítulo N° 1 está compuesto por los antecedentes del problema de investigación, planteamiento del problema, y marco teórico, principalmente. Para ello, en este capítulo se hicieron uso de ciertas definiciones de términos claves y se encontraron las limitaciones existentes del estudio, así como también se usaron autores principales del empoderamiento gerencial de la mujer y los roles gerenciales. En el capítulo N° 2 se realizó el resumen histórico para ambas variables y se encontraron los principales hallazgos de los estudios ejecutados en el transcurso del tiempo del empoderamiento gerencial de la mujer y los roles gerenciales. En el capítulo N° 3, se determinó la metodología del estudio y, a su vez, se halló el tamaño de la población y muestra, así como también se determinó el instrumento de estudio. En el capítulo N° 4, se realizaron diversas pruebas estadísticas para poder probar las hipótesis señaladas en el presente trabajo, en el cual se confirmó que sí existe una relación entre ambas variables. En el capítulo N° 5, se realizaron las conclusiones y recomendaciones del presente estudio, en la cual se afirma que existe una relación entre el empoderamiento gerencial de la mujer y los roles gerenciales en el sector de Consumo Masivo en Lima Metropolitana en el año 2023.
Análisis jurídico de la obligatoriedad del sufragio en la Constitución Política del Perú de 1993: ¿Un paralogismo o acierto?
Authors:   , Montoya Arenas Diego
Published: May 2024

La presente tesis se enfoca en el análisis jurídico e histórico del derecho al sufragio y su obligatoriedad en el marco de la Constitución Política del Perú de 1993. Los conceptos teóricos generales del derecho a la libertad y del sufragio junto con su evolución histórica como concepción jurídica son desarrollados en el Capítulo I. En el Capítulo II, se aplica un análisis de legislación comparada considerando la evolución del sufragio obligatorio y/o facultativo en Europa, América y Australia, con particular enfoque en los debates legislativos de los países de estas regiones. El Capítulo III aborda el análisis jurídico del voto, tratando la dualidad del derecho de sufragio, la ratio legis del sufragio obligatorio, la multa como penalización por no votar, el estatus de los votos en blanco, así como las virtudes y desventajas del sufragio facultativo. Finalmente, en función a las conclusiones de la presente investigación, en la sección de recomendaciones se propone una reforma jurídica en el marco constitucional y electoral.
Propuesta de pavimento de bajo costo mediante base estabilizada con aditivo químico BS-100 para caminos de bajo volumen de tránsito en la Vía Vecinal Picuro-Gengen, Iquitos
Authors:   , Ramirez Salazar Romanuel
Published: May 2024

Este trabajo se origina debido a la carencia de opciones sustentables para pavimentar en vías rurales de bajo flujo vehicular en la región Amazónica, debido a los gastos elevados que requieren los rubros de transporte y movimiento de tierras relacionados con los enfoques tradicionales de pavimentación, y la insuficiencia de recursos naturales en el área para aprovisionar esta clase de proyectos, por lo tanto, esta investigación sugiere una estructura de pavimentación conformada por una base estabilizada con un aditivo estabilizador de tipo BS-100 como superficie de rodaje para este tipo de rutas. Se efectuó un análisis técnico económico a un proyecto de inversión público, donde se comparó la aplicación del método convencional de pavimentación aplicado en la zona de estudio y la propuesta de pavimentación con base estabilizada con aditivo estabilizador BS-100 analizada en esta investigación, en la cual se verificó que ambas alternativas cumplan con el criterio estructural necesario para satisfacer la demanda existente y atraída del proyecto. Asimismo, analizando la alternativa propuesta se evidenció una disminución del 71.52% en el costo directo del proyecto en comparación con el método convencional de pavimentación, una reducción de 33% en los plazos de ejecución y un aprovechamiento óptimo de los recursos naturales, evidenciando la viabilidad de esta propuesta para futuros proyectos que permitan el desarrollo y la faciliten la intercomunicación entre los pueblos de la región Amazónica.
Solución tecnológica basada en IA conversacional para un servicio de atención al cliente inteligente
Authors:   , Chumpitaz Terry Alessandro , Yanqui Huarocc Liliana
Published: May 2024

Los asistentes virtuales se utilizan para enriquecer la experiencia del usuario en diversos sitios web de comercio electrónico y servicios en línea. Varios estudios indican que mejorar la experiencia del usuario es posible si el asistente virtual simula una interacción humana o si facilita la adquisición de productos o servicios específicos. Para lograr este objetivo, los asistentes pueden emplear técnicas de Procesamiento del Lenguaje Natural para comprender el lenguaje humano y ofrecer respuestas adecuadas. Este estudio se centra en el desarrollo de un asistente virtual basado en inteligencia artificial para un sitio web dedicado a la venta de productos avícolas, con el fin de mejorar la experiencia del cliente. Para evaluar los beneficios de esta implementación, se recopilaron comentarios de un grupo de 58 clientes en la ciudad de Lima que interactuaron con el asistente virtual. Los resultados demostraron que el asistente virtual tuvo un impacto positivo en el servicio al cliente, con un índice de aceptación promedio del 83.66% en términos de usabilidad, funcionalidad y satisfacción del cliente.
ANÁLISIS DEL DISCURSO PERIODÍSTICO EN LA SEGUNDA VUELTA PRESIDENCIAL 2021: REVISIÓN DE PORTADAS DE PERÚ21
Authors:   , Aguayo Quintos Leonardo
Published: May 2024

El estudio detallado de las portadas del diario Perú21 se enfoca en analizar la intencionalidad y el procedimiento detrás de la elección y disposición de las imágenes en su versión digital. Mediante un enfoque cualitativo, se examinaron 17 portadas seleccionadas, desvelando un marcado sesgo en la representación de Pedro Castillo, con una inclinación a omitir contenido que pudiera perjudicar a Keiko Fujimori. Frecuentemente, se evidenció que las imágenes escogidas no capturaban el aspecto más relevante de las noticias. Este análisis resalta cómo el encuadre de agenda, que determina el enfoque temático de la cobertura informativa, es empleado con eficacia por los medios impresos para influir en la opinión pública. Finalmente, se constató, que las portadas fueron diseñadas ajustando el contenido para con una intención desfavorable para el candidato presidencial Pedro Castillo.
Percepción de la población indígena andina sobre su representación en la campaña “Intercambiados”.
Authors:   , Mendoza Rázuri Maria
Published: May 2024

Este estudio analiza la percepción de las personas indígenas sobre su representación usada en la construcción de una marca país, la estrategia que utilizan las naciones para mejorar su reputación y abrir las puertas para empresas o turistas internacionales. Se analizó la narrativa de la campaña “Intercambiados” de Marca Perú que fue grabada en la Isla Taquile de Puno, adaptando una metodología cualitativa con el fin de recolectar las percepciones de las personas indígenas de la que residen en esta y se desempeñen en el rubro turístico sobre su representación en el material audiovisual. Según lo revisado, la representación indígena en los medios de comunicación y, específicamente en la publicidad, a través de la historia, ha estado cargada de estereotipos, lo que provoca que se les exotice y trate de manera distante, agravando su estado de vulnerabilidad. Palabras clave: Representación; pueblos indígenas; estereotipos; marca país; narrativa.
La responsabilidad social corporativa y su relación con la ventaja competitiva en los clientes internos de las empresas del sector transporte de pasajeros en Lima Metropolitana en el 2023
Authors:   , Leyton Cruzado Juan , Romero Mori Daniela
Published: May 2024

Las industrias peruanas aún luchan con la falta de comprensión de la responsabilidad social corporativa y las ventajas competitivas que trae a las organizaciones. En una empresa, tanto los clientes internos como los externos pueden experimentar estas ventajas. Estos, sin embargo, no se utilizan porque la mayoría de los ejecutivos de empresas lo consideran poco importante. Este proyecto examina cómo un equipo de colaboradores percibe el vínculo entre la responsabilidad social corporativa y una ventaja competitiva entre los clientes internos. Para ello, se aplicaron 379 encuestas a trabajadores del sector transporte de pasajeros en 2023. Se examinaron las variables motivación laboral, economía y cultura empresarial para la variable ventaja competitiva. Según los resultados de la encuesta, existe una fuerte correlación entre la ventaja competitiva y la responsabilidad social empresarial en las tres áreas mencionadas.
Propuesta de mejora en el proceso de recolección de información para la realización de informes técnicos en una empresa ambiental mediante el uso de la herramienta de Data Analytics y 5S
Authors:   , Chavez Osorio Gianella , Guillen Valdivia Sebastian
Published: May 2024

La herramienta Data Analytics hace posible que todas las organizaciones respondan con agilidad, realicen cambios a tiempo, toma de decisiones inteligentemente y ejecución rápida. La empresa en el tiempo actual es el principal representante del desarrollo, porque es imperativo e inaplazable que todos los empresarios laboren para crear prácticas de acción política y social responsables en una compartida cultura que accede la interacción de costumbres y valores de las diferentes sociedades. En la realización de Ciper se involucra el proceso de recolección y el desarrollo de todas las actividades clave en manejo de información y procesamiento de documentos. La razón principal del proyecto comprende integrar la parte del conocimiento aprendido en clases con la práctica y establecer vínculos de información y mejoras, en la parte inicial de la entrevista con el Gerente general de Ciper Consulting se realizó las preguntas correspondientes a la gestión de la empresa y a los principales retos que tiene la empresa en la recolección y manejo de los informes técnicos donde uno de los principales puntos es la data generada por la empresa en los años correspondiente del 2011 al 2020 y que permite tener una fuente de riqueza para una mejor toma de decisiones. Muy a menudo suele confundirse que al tratar de Data Analytics es un software que procesa información y que se desarrolla con todos los colaboradores que ya están familiarizados con el manejo y desarrollo de las actividades.
Relación entre la utilización de la plataforma B2B “Peru Marketplace” de Promperú y el desempeño exportador de las pymes peruanas del sector cacao entre los años 2020-2022
Authors:   , Guevara Yáñez Jorge , Garcia Tapia Ashley
Published: May 2024

El Perú es uno de los principales lugares originarios del cacao y cuenta con el 60% de las variedades de cacao en el mundo (Palma, 2018). Debido a ello, el cacao peruano se ha convertido en uno de los principales ingredientes peruanos con mayor calidad mundial generando así un importante valor agregado en las fábricas chocolateras. Dichos acontecimientos han impulsado a que el Perú se posicione en tercer lugar como el mayor productor de la región. Por lo tanto, el Gobierno del Perú ha buscado promover su consumo y su internacionalización a través de distintas medidas, como la implementación de ciertas plataformas y programas como con el caso de “Perú Marketplace de Promperú”, el cual dispone de una línea específica de cacao publicada en su plataforma web lo cual permite promocionar la oferta exportable peruana (Municipalidad de Lima, s.f.). De este modo, la presente investigación tiene como objetivo principal determinar si la participación en la plataforma virtual B2B “Perú Marketplace” de Promperú se relaciona con el desempeño exportador de las empresas pymes exportadoras de cacao y sus derivados entre los años 2020-2022. Para ello, las dimensiones analizadas para la variable “Peru Marketplace” son: Conocimiento Exportador, Contacto con comprador extranjero y Compromiso Exportador. Asimismo, para la variable “Desempeño Exportador” se han analizado: Desempeño Comercial y Estrategia de Expansión Internacional. Esta investigación cuenta con un enfoque mixto y diseño no experimental transversal correlacional. Para el estudio cualitativo se llevaron a cabo 16 entrevistas a pymes exportadoras y 2 entrevistas a expertos de la entidad Promperú, analizados mediante el programa Atlas Ti. En cuanto al análisis cuantitativo se diseñó una encuesta cerrada a escala de Likert a 18 pymes exportadoras de cacao que se analizaron mediante el software SPSS.
Analysis of actual results of drug supply implementation within framework of High-Cost Nosologies Program
Authors: Ivakhnenko O. I. , Ryazhenov V. V. , Maksimkina E. A. , Fisenko V. S. , Savoskin O. V. , Kuznetsova M. M.
Published: May 2024

The accessibility and pharmaceutical care coverage are linked to political, economic and managerial decisions. That fact necessitates the evaluation of the state programs results in the field of the drug provision.

The aim of the work was to assess the quantitative results of the implementation of the High-Cost Nosologies program in the Russian Federation from 2008 to 2023 to determine further vectors of its improvement.

Materials and methods. The regulatory base of the work was made up of the Russian Federation legislation in the field of the drug provision. The open sources were used as the research information base for the data collection and analysis: reports of federal and regional executive authorities, materials of specialized conferences, results of published studies.

Results. The drug coverage under the High-Cost Nosologies (VZN) program is provided for 14 nosologies, 11 of which are classified as orphan diseases. Since its implementation, the HCNs program has been expanded twice by including new nosologies in 2019 and 2020. As of 01 October 2023, the number of patients in the Federal Register of VZN was 263 721 people, which was 13.58 times greater compared to 2008. The drug provision is carried out according to the list of 47 INNs. The amount of funding for the program increased from RUB 32 bn in 2008 to RUB 87.96 bn in 2023. The most resource-intensive nosologies include hemophilia, multiple sclerosis and oncohematology.

Conclusion. The main quantitative characteristics of the implementation of the HCNs program and the identified vectors for its further improvement have been analyzed in this study. The results obtained can be used to conduct analytical studies, including the ones within nosologies and nosological groups included in the program, in order to optimize a pharmaceutical care. The focus of improving the implementation of the VZN program is related to the improvement of the legal framework, a patient treatment paradigm and approaches to its financing.
Development of a method for quantitative determination of nitric oxide (NO) in rat tissues based on high-performance liquid chromatography and mass spectrometry
Authors: Popov N. S. , Gavrilenko D. A. , Baranov M. S. , Balabanyan V. Yu.
Published: May 2024

A quantitative assessment of nitric oxide (NO) production in body tissues is an urgent problem in pharmacology and biochemistry. The study of physiological processes occurring with the participation of NO, as well as the metabolism and pharmacodynamics of pharmacological agents from the group of NO donors, requires the introduction of accurate and reproducible methods for the quantitative determination of this metabolite in biological media.

The aim of the study was to develop the HPLC-MS/MS methods for the quantitative determination of NO in various tissues of rats.

Materials and methods. The indirect NO quantification was based on estimation of the level of more stable metabolites: nitrites and nitrates extracted from rat tissues by homogenization with water. The reduction of nitrates to nitrites was carried out using nitrate reductase. The derivatization of nitrites was based on a reaction with Griess reagent. The resulting azo dye was determined by HPLC-MS/MS using an Agilent InfinityLab Poroshell 120 EC-C18 4.6×100 mm, 2.7 μm analytical column. The total chromatographic analysis time was 12 minutes, and the analyte retention time was 6.1 minutes. The analytical range of the method was 0.1–100.0 nmol (in terms of nitrite) per 1 ml of plasma or tissue homogenate.

Results. The developed a bioanalytical method was validated according to the following parameters: a selectivity, a matrix effect, a recovery degree, a sample transfer, an analytical range linearity, a lower limit of quantification (LLOQ), an intra- and inter-assay accuracy and precision, and a stability at all the stages of the analysis. To test the method, the NO content in the plasma, brain, heart, aorta and lungs of rats was determined.

Conclusion. The developed bioanalytical HPLC-MS/MS methods fully meets the validation requirements. The metrological characteristics of the technique make it possible to highly accurately estimate the NO production in various tissues of rats, which is undoubtedly relevant and in demand in the study of pathological processes as well as the mechanism of action of pharmacological agents from the group of NO donors.
SIPELAPAK LIAR (SISTEM PENGAWASAN DAN PELAPORAN PARKIR LIAR): PERANCANGAN APLIKASI PENGAWASAN DAN PELAPORAN SEBAGAI SOLUSI PENANGANAN PARKIR LIAR DI KOTA DENPASAR
Authors: Ananda Lukita Mulya , Mukti Kadek Cakra Wisnu , Pranajaya A.A. Sagung Intan Aprilia , Firdaus Ferdi , Suartawan Putu Eka
Published: May 2024

Today, many people already have private vehicles such as cars and motorcycles, which causes the number of private vehicles to increase in Indonesia. This causes transportation problems, namely the availability of parking spaces that are not proportional to the number of vehicles. These problems lead to the occurrence of illegal parking which can hinder the smooth flow of traffic. The location of the case study in this research is in the area of Denpasar City. Utilization of information technology is a solution in overcoming illegal parking. One of them is by designing an application in the form of a monitoring and reporting system called SIPELAPAK LIAR (Sistem Pengawasan dan Pelaporan Parkir Liar). The materials for this application are Sublime Text 3, Google Chrome, and Xampp Version 7.4. Sublime Text 3. This application aims as a forum for the community to assist the government in efforts to reduce illegal parking. It is hoped that this application can help advance the quality of service in Denpasar City in overcoming the problem of illegal parking.
ABSTRAK
Dewasa ini, banyak masyarakat yang telah memiliki kendaraan pribadi seperti mobil dan sepeda motor yang menyebabkan membludaknya jumlah kendaraan pribadi di Indonesia. Hal ini menimbulkan masalah transportasi yaitu ketersediaan lahan parkir yang tidak sebanding dengan jumlah kendaraan. Permasalahan tersebut menyebabkan terjadinya parkir liar yang dapat menghambat kelancaran lalu lintas. Lokasi studi kasus pada penelitian ini yaitu di wilayah Kota Denpasar. Pemanfaatan teknologi informasi menjadi solusi dalam mengatasi parkir liar. Salah satunya dengan perancangan aplikasi berupa sistem pengawasan dan pelaporan yang diberi nama SIPELAPAK LIAR (Sistem Pengawasan dan Pelaporan Parkir Liar). Bahan pembuatan aplikasi ini yaitu Sublime Text 3, Google Chrome, dan Xampp Versi 7.4. Sublime Text 3. Aplikasi ini bertujuan sebagai wadah bagi masyarakat untuk membantu pemerintah dalam upaya mengurangi parkir liar. Diharapkan aplikasi ini mampu membantu memajukan kualitas pelayanan di Kota Denpasar dalam mengatasi masalah parkir liar.
PENINGKATAN KINERJA SIMPANG BERSINYAL TEGALLEGA BERDASARKAN PEMODELAN SIMPANG KOORDINASI
Authors: Reina Amanda Dwi , Akbardin Juang , Ma’soem Dadang M.
Published: May 2024

Population growth in Bandung Bandung encourages higher activity so it increases the number of vehicles at intersections. Congestion often occurs during peak hours, including at three adjacent intersections namely PT Inti Intersection, Tegallega Intersection, and Leuwi Panjang Intersection which are 332 meters and 622 meters apart. A solution is needed to make the performance of the intersection improves so that it remains safe and comfortable when passing. The data used are traffic flow at peak hours, vehicle speed, cycle time, and intersection geometry. Analysis was carried out using PKJI 2014 and micro-simulation-based analysis using PTV Vissim so the existing condition and alternative performance improvements can be defined. From alternatives 1, 2, and 3 at peak hours the best result obtained is the second alternative with a cycle time of 203 seconds. Alternative 2 decreases 14,9% of queue length, 20,11% of delay, and 0,3 of level of service.
ABSTRAK
Pertumbuhan penduduk di Kota Bandung mendorong aktivitas yang semakin tinggi sehingga meningkatkan jumlah kendaraan di persimpangan. Pada jam-jam sibuk seringkali ditemui kemacetan termasuk di tiga simpang berdekatan yakni Simpang PT Inti, Simpang Tegallega, dan Simpang Leuwi Panjang yang berjarak masing-masing 332 meter dan 622 meter. Dibutuhkan suatu solusi dalam meningkatkan kinerja simpang agar tetap aman dan nyaman saat dilewati. Data yang digunakan adalah kecepatan kendaraan, arus lalu lintas pada jam puncak, waktu siklus, dan geometri simpang. Pada penelitian dilakukan analisis menggunakan PKJI 2014 kemudian analisis berbasis mikro-simulasi menggunakan perangkat lunak PTV Vissim sehingga kondisi kinerja simpang eksisting dan alternatif peningkatan kinerja simpang dapat didefinisikan. Hasil analisis didapatkan dari perencanaan Alternatif 1, 2, dan 3 pada jam puncak yang terbaik yakni alternatif kedua dengan waktu siklus 203 detik. Alternatif 2 menghasilkan penurunan panjang antrian 14,9%, tundaan 20,11%, dan derajat kejenuhan sebesar 0,3.
ESTIMASI DISTRIBUSI PERGERAKAN DI KABUPATEN SRAGEN DENGAN METODE INFERENSI-BAYES DAN FUNGSI HAMBATAN EKSPONENSIAL NEGATIF
Authors: Krisnanda Cesario Alvian , Syafi’i  , Handayani Dewi
Published: May 2024

Huge intensity of activities in a specific area could cause transportation problems. Therefore, it’s important to make a transportation planning, especially in the form of an origin-destination matrix using the Gravity Model and β parameter as the resistance function. This study’s goal was to acquire the value of the β parameter, study area’s total movement, and the validity level of the modeled traffic flow compared to the observed traffic flow. This Origin Destination Matrix estimations used the Gravity Model with generation and pulls as the constrains helped by the EMME/3 application. This Origin Destination Matrix estimation needed β parameter that’s obtained by the Newton-Raphson Calibration Method with the User Equilibrium method resulted in modeled traffic flow. The β parameter of this study obtained from Microsoft Excel program calculations, which was 0.0800. The Origin Destination Matrix estimation bring out the total movement estimation of Sragen District in 2022 was 9,892 pcu/hour and had the validity level (R2) of 0.7851.
ABSTRAK
 
Intensitas tinggi aktivitas di suatu area tertentu bisa menyebabkan permasalahan transportasi. Oleh karena itu, perlu dibentuk perencanaan transportasi, khususnya dalam bentuk Matriks Asal Tujuan menggunakan Model Gravity dan parameter β sebagai fungsi hambatan. Tujuan dari penelitian ini adalah untuk mendapatkan nilai parameter β, total pergerakan dalam wilayah kajian, dan tingkat validitas arus lalu lintas hasil pemodelan yang didapat dari pembandingan dengan arus lalu lintas pengamatan. Estimasi Matriks Asal Tujuan ini menggunakan Model Gravity dengan bangkitan dan tarikan sebagai batasan yang dibantu dengan aplikasi EMME/3. Estimasi Matriks Asal Tujuan ini membutuhkan parameter β yang didapatkan dengan Metode Kalibrasi Newton-Raphson dengan Metode User Equilibrium yang menghasilkan arus lalu lintas pemodelan. Parameter β yang didapatkan dari penelitian ini didapatkan dari kalkulasi program aplikasi Microsoft Excel adalah sebesar 0,0800. Estimasi Matriks Asal Tujuan menghasilkan total pergerakan estimasi dari Kabupaten Sragen pada tahun 2022 adalah 9.892 smp/jam dan memiliki tingkat validitas (R2) sebesar 0,7851.
PENINGKATAN PELAYANAN JALAN MELALUI PERENCANAAN TRAFFIC LIGHT PADA SIMPANG TIGA JL. ANTANG RAYA - JL. UJUNG BORI KOTA MAKASSAR
Authors: Zakaria Aisyah , Anton Erning Ertami , Ananda A. Ansyar , Tajuddin Armansyah
Published: May 2024

Jl. Antang Raya-Jl. Ujung Bori’s intersection is an unsignalized intersection in Makassar City that has traffic problems and need attention because its activities are increasing day by day, especially mobility enhancement of shopping, office, and business activities that cause congestion. This study aims to determine the timing of the traffic light based on the MKJI 1997 guidelines with 3 signal phases and road widening which results in a service level of C (DS < 0.75). It is planned that the effective road width is 7 meters for each intersection arm with a cycle time of 52 seconds and a yellow time of 3 seconds. For setting traffic lights for the southern arm, red and green times are 39 and 10 seconds. For the northern arm, red and green times are 35 and 14 seconds. For the western arm, red and green times are 33 and 16 seconds.
ABSTRAK
Simpang Jl. Antang Raya-Jl. Ujung Bori merupakan persimpangan tidak bersinyal di Kota Makassar yang mengalami permasalahan lalu lintas dan perlu diperhatikan dikarenakan aktivitasnya yang kian meningkat tiap harinya, terutama peningkatan pergerakan kegiatan perbelanjaan, perkantoran, dan bisnis yang menyebabkan kemacetan. Penelitian ini bertujuan untuk menentukan waktu traffic light berdasarkan pedoman MKJI 1997 dengan 3 fase sinyal dan melalui pelebaran jalan yang menghasilkan tingkat pelayanan C (DS < 0,75). Direncanakan lebar jalan efektif 7 meter tiap lengan simpang dengan waktu siklus 52 detik dan waktu kuning 3 detik. Untuk pengaturan traffic light lengan selatan diperoleh waktu merah dan hijau, yaitu 39 dan 10 detik. Untuk lengan utara diperoleh waktu merah dan hijau yaitu 35 dan 14 detik. Untuk lengan barat diperoleh waktu merah dan hijau yaitu 33 dan 16 detik.
ANALISIS TINGKAT PELAYANAN PEJALAN KAKI BERDASARKAN KARAKTERISTIK PEJALAN KAKI DAN KINERJA INFORMASI PENUMPANG PADA STASIUN DUKUH ATAS
Authors: Raflipasya Muhammad Abyan , Adwitiya R. Ivan , Sumabrata Jachrizal
Published: May 2024

Dukuh Atas Station area is a place where the Transit Oriented Development concept was developed. To maximize the TOD, good pedestrian facilities are needed. The purpose of the study was to analyze the level of pedestrian service, characteristics, and passenger information in the Dukuh Atas Station area. This type of research was conducted with a quantitative approach. The independent variables of this study were pedestrian time and pavement dimensions. The dependent variables of this study are speed, flow, density, pedestrian space, and level of service. The method of collecting data is by means of a field survey to measure the dimensions of the sidewalk and record pedestrian movements for 1 hour in the morning and 1 hour in the afternoon 1 location. Data processing is calculating pedestrian speed, flow, density, pedestrian space. The results of this study are the level of pedestrian service in the Dukuh Atas Station area.
ABSTRAK
Kawasan Stasiun Dukuh Atas merupakan tempat yang dikembangkan konsep Transiet Oriented Development. Untuk memaksimalkan TOD, dibutuhkannya fasilitas pejalan kaki yang baik. Tujuan penelitian untuk menganalisis tingkat pelayanan pejalan kaki, karakteristik, dan informasi penumpang pada kawasan Stasiun Dukuh Atas. Jenis penelitian ini dilakukan dengan pendekatan kuantitatif. Variabel bebas penelitian ini adalah waktu pejalan kaki dan dimensi trotoar. Variabel terikat penelitian ini adalah kecepatan, arus, kepadatan, ruang pejalan kaki, dan tingkat pelayanan. Metode pengumpulan data dengan cara survei lapangan untuk mengukur dimensi trotoar dan merekam pergerakan pejalan kaki selama 1 jam pada pagi hari dan sore hari pada 3 lokasi, lalu dilanjutkan dengan perhitungan kecepatan dan jumlah pejalan kaki berdasarkan rekaman yang sudah didapat. Selanjutnya, dilakukan identifikasi terhadap informasi penumpang yang tersedia pada lokasi penelitian. Pengolahan data dilakukan dengan menghitung kecepatan pejalan kaki, arus, kepadatan, ruang pejalan kaki. Hasil penelitian ini adalah tingkat pelayanan pejalan kaki pada kawasan Stasiun Dukuh Atas.
PENILAIAN KRITERIA PELABUHAN PENYEBERANGAN “HIJAU” DALAM RANGKA PEMBANGUNAN BERKELANJUTAN: STUDI KASUS PELABUHAN PENYEBERANGAN MERAK
Authors: Saputra Muhammad Hendra , Christin Gloriani Novita
Published: May 2024

The “Green” Ferry Port is an environmentally friendly port or also known as an ecoport. The sustainable development of ports in the future must be committed to making green ports that utilize information technology to build prosperity for present and future generations. For this purpose, port sustainability will be at the core of development strategies and plans beyond systems and policies. This could be the most important step for ports to become a more sustainable business, setting the foundation for growth. The concept of sustainability for ports is the integration of environmentally friendly methods of port activities, operations and management. Each development causes the minimum possible impact, contributing to improved actions and controls for air, water, noise, and waste quality.
ABSTRAK
Pelabuhan Penyeberangan “Hijau” merupakan pelabuhan yang berwawasan lingkungan atau juga disebut dengan ecoport. Pembangunan berkelanjutan pelabuhan di masa depan harus berkomitmen untuk menjadikan pelabuhan hijau yang memanfaatkan teknologi informasi untuk membangun kemakmuran bagi generasi sekarang dan masa depan. Untuk tujuan ini, keberlanjutan pelabuhan akan menjadi inti dan strategi dan rencana pembangunan di luar sistem dan kebijakan. Ini bisa menjadi langkah paling penting bagi pelabuhan untuk menjadi bisnis yang lebih berkelanjutan, menetapkan fondasi untuk berkembang. Konsep keberlanjutan untuk pelabuhan adalah integrasi metode kegiatan, operasi, dan manajemen pelabuhan yang ramah lingkungan. Setiap perkembangan menyebabkan dampak seminimal mungkin, berkontribusi pada peningkatan tindakan dan kontrol untuk kualitas udara, air, kebisingan, dan limbah.