bluuebunny/crossref_metadata_2025 huggingface dataset:
Control of a Multiphase Buck Converter, Based on Sliding Mode and Disturbance Estimation, Capable of Linear Large Signal Operation
Authors: Pajer Rok , Chowdhury Amor , Rodič Miran
Published: July 2019

Power-hardware-in-the-loop systems enable testing of power converters for electric vehicles (EV) without the use of real physical components. Battery emulation is one example of such a system, demanding the use of bidirectional power flow, a wide output voltage range and high current swings. A multiphase synchronous DC-DC converter is appropriate to handle all of these requirements. The control of the multiphase converter needs to make sure that the current is shared equally between phases. It is preferred that the closed-loop dynamic model is linear in a wide range of output currents and voltages, where parameter variations, control signal limits, dead time effects, and so on, are compensated for. In the case presented in this paper, a cascade control structure was used with inner sliding mode control for phase currents. For the outer voltage loop, a proportional controller with output current feedforward compensation was used. Disturbance observers were used in current loops and in the voltage loop to compensate mismatches between the model and the real circuit. The tuning rules are proposed for all loops and observers, to simplify the design and assure operation without saturation of control signals, that is, duty cycle and inductor current reference. By using the proposed control algorithms and tuning rules, a linear reduced order system model was devised, which is valid for the entire operational range of the converter. The operation was verified on a prototype 4-phase synchronous DC-DC converter.
A Feasibility Study of Fabrication of Piezoelectric Energy Harvesters on Commercially Available Aluminum Foil
Authors: Yoon Chongsei , Jeon Buil , Yoon Giwan
Published: July 2019

In this paper, we present zinc oxide (ZnO)-based flexible harvesting devices employing commercially available, cost-effective thin aluminum (Al) foils as substrates and conductive bottom electrodes. From the device fabrication point of view, Al-foils have a relatively high melting point, allowing for device processing and annealing treatments at elevated temperatures, which flexible plastic substrate materials cannot sustain because of their relatively low melting temperatures. Moreover, Al-foil is a highly cost-effective, commercially available material. In this work, we fabricated and characterized various kinds of multilayered thin-film energy harvesting devices, employing Al-foils in order to verify their device performance. The fabricated devices exhibited peak-to-peak output voltages ranging from 0.025 V to 0.140 V. These results suggest that it is feasible to employ Al-foils to fabricate energy-efficient energy harvesting devices at relatively high temperatures. It is anticipated that with further process optimization and device integration, device performance can be further improved.
An Innovative Planning Method for the Optimal Capacity Allocation of a Hybrid Wind–PV–Pumped Storage Power System
Authors: Xu Yumin , Lang Yansheng , Wen Boying , Yang Xiaonan
Published: July 2019

In recent years, wind and photovoltaic power (PV) have been the renewable energy sources (RESs) with the greatest growth, and both are commonly recognized as the major driving forces of energy system revolution. However, they are characterized by intermittency, volatility and randomness. Therefore, their stable and efficient implementation is one of the most significant topics in the field of renewable energy research. In order to improve the stability of RESs and reduce the curtailment of wind and solar energy, this paper proposes an innovative planning method for optimal capacity allocation. On one hand, a new power generation system is introduced which combines a pumped storage power station with a wind farm and PV; on the other hand, the sequential Monte Carlo method is utilized to analyze the economy and reliability of the system under different capacity configurations considering investment cost, operating characteristics and influence factors of wind and solar energy. Then, optimal capacity allocation can be achieved. In summary, this proposed scheme provides an effective solution for the planning and construction of a new power generation system with RESs.
Solution for Voltage and Frequency Regulation in Standalone Microgrid using Hybrid Multiobjective Symbiotic Organism Search Algorithm
Authors: Teekaraman Yuvaraja , Kuppusamy Ramya , Nikolovski Srete
Published: July 2019

Voltage and frequency regulation is one of the greatest challenges for proper operation subsequent to the isolated microgrid. To validate the satisfactory electric power quality supply to customers, the proposed manuscript tries to enhance the quality of energy provided by DG (Distributed generation) units connected to the subsequent isolated grid. Microgrid and simulation-based control structure including voltage and current control feedback loops is proposed for microgrid inverters to recover voltage and frequency of the system subsequently for any fluctuations in load change. The proportional-integral (PI) controller connected to the voltage controller is an end goal to obtain smooth response in most of the consistent frameworks. The present controller creates the space vector pulse width modulation signals which are given to the three-leg inverter. The objective elements of the multiobjective optimization issue are voltage overshoot and undershoot, rise time, settling time, and integral time absolute error (ITAE). The hybrid Multiobjective Symbiotic Organism Search (MOSOS) calculation is associated for self-tuning of control parameters keeping in mind the end goal to deal with the voltage and frequency. The proposed PI controller, along with the hybrid Multiobjective Symbiotic Organism Search algorithm, provides the solution for the greatest challenge of voltage and frequency regulation in an isolated-microgrid operation.
A Novel Multi-Agent-Based Collaborative Virtual Manufacturing Environment Integrated with Edge Computing Technique
Authors: Zhang Xiaohui , Tang Shufeng , Liu Xinhua , Malekian Reza , Li Zhixiong
Published: July 2019

This paper proposes a multi-agent-based collaborative virtual manufacturing environment (VME) to save energy consumption and improve efficiency in the manufacturing process. In order to achieve the high autonomy of the manufacturing system, a multi-agent system (MAS) is designed to build a collaborative VME. In this new VME environment, edge computing is embedded to strengthen the cyber resource utilization and system economy. Moreover, an efficient communication channel between networks is proposed. The subsequent cooperation and collaboration protocols among agents are designed to ensure flexible and process-oriented operations. Furthermore, the fuzzy resolution algorithm is employed to resolve the competition conflicts among function-similar MASs in the distributed manufacturing scenario. Lastly, a simulation and case study are performed to evaluate the performance of the proposed VME in Internet of Things (IoT)-based manufacturing. The analysis results have demonstrated the feasibility and effectiveness of the proposed VME system.
Evaluation of Infrared Radiation Combined with Hot Air Convection for Energy-Efficient Drying of Biomass
Authors: EL-Mesery Hany S. , Abomohra Abd El-Fatah , Kang Chan-Ung , Cheon Ji-Kwang , Basak Bikram , Jeon Byong-Hun
Published: July 2019

Cost-effective biomass drying is a key challenge for energy recovery from biomass by direct combustion, gasification, and pyrolysis. The aim of the present study was to optimize the process of biomass drying using hot air convection (HA), infrared (IR), and combined drying systems (IR-HA). The specific energy consumption (SEC) decreased significantly by increasing the drying temperature using convective drying, but higher air velocities increased the SEC. Similarly, increasing air velocity in the infrared dryer resulted in a significant increase in SEC. The lowest SEC was recorded at 7.8 MJ/kg at an air velocity of 0.5 m/s and an IR intensity of 0.30 W/cm2, while a maximum SEC (20.7 MJ/kg) was observed at 1.0 m/s and 0.15 W/cm2. However, a significant reduction in the SEC was noticed in the combined drying system. A minimum SEC of 3.8 MJ/kg was recorded using the combined infrared-hot air convection (IR-HA) drying system, which was 91.7% and 51.7% lower than convective and IR dryers, respectively. The present study suggested a combination of IR and hot air convection at 60 °C, 0.3 W/cm2 and 0.5 m/s as optimum conditions for efficient drying of biomass with a high water content.
Exploring the Profitability and Efficiency of Variable Renewable Energy in Spot Electricity Market: Uncovering the Locational Price Disadvantages
Authors: Xu Ruhang , Liu Zhilin , Yu Zhuangzhuang
Published: July 2019

While variable renewable energy (VRE) has been developed for decades, VRE market participation is developing relatively slowly, despite the potential economic efficiency it may bring. This paper tries to specify the efficiency of VRE in a deregulated pool-based electricity market. Based on standard pool-based market design, this paper built a direct current optimal power flow (DC-OPF) based simplified 2-settlement spot electricity market model conjugating electricity and ancillary service clearing. To address the outcomes of the imperfect market in the real world, this paper studied the consequences brought by agents’ learning and strategic behaviors. Simulations under different ancillary service levels and reliability cost levels are carried out. The results show that VRE may be unprofitable in the market, especially when learning and strategic behavior is considered. Learning and strategic market behavior will also hamper the role of VRE as a “better” energy source. This paper shows and proves a locational marginal price (LMP) disadvantage phenomenon, which will lead to low profitability of VRE. Three major suggestions are given based on the results.
Diesel Mean Value Engine Modeling Based on Thermodynamic Cycle Simulation Using Artificial Neural Network
Authors: Ko Eunhee , Park Jungsoo
Published: July 2019

This study aims to construct a reduced thermodynamic cycle model with high accuracy and high model execution speed based on artificial neural network training for real-time numerical analysis. This paper proposes a method of constructing a fast average-value model by combining a 1D plant model and exhaust gas recirculation (EGR) control logic. The combustion model of the detailed model uses a direct-injection diesel multi-pulse (DI-pulse) method similar to diesel combustion characteristics. The DI-pulse combustion method divides the volume of the cylinder into three zones, predicting combustion- and emission-related variables, and each combustion step comprises different correction variables. This detailed model is estimated to be within 5% of the reference engine test results. To reduce the analysis time while maintaining the accuracy of engine performance prediction, the cylinder volumetric efficiency and the exhaust gas temperature were predicted using an artificial neural network. Owing to the lack of input variables in the training of artificial neural networks, it was not possible to predict the 0.6–0.7 range for volumetric efficiency and the 1000–1200 K range for exhaust gas temperature. This is because the mean value model changes the fuel injection method from the common rail fuel injection mode to the single injection mode in the model reduction process and changes the in-cylinder combustion according to the injection timing of the fuel amount injected. In addition, the mean value model combined with EGR logic, i.e., the single-input single-output (SISO) coupled mean value model, verifies the accuracy and responsiveness of the EGR control logic model through a step-transient process. By comparing the engine performance results of the SISO coupled mean value model with those of the mean value model, it is observed that the SISO coupled mean value model achieves the desired target EGR rate within 10 s. The EGR rate is predicted to be similar to the response of volumetric efficiency. This process intuitively predicted the main performance parameters of the engine model through artificial neural networks.
A General Framework for Voltage Sag Performance Analysis of Distribution Networks
Authors: Safdarian Amir , Fotuhi-Firuzabad Mahmud , Lehtonen Matti
Published: July 2019

The proliferation of more sensitive loads has obliged distribution companies to pay greater attention to the voltage sag mitigation potential of different design alternatives in network planning studies. In doing so, a company has to have effective tools for estimating the voltage sag performance of its network. In this regard, this paper establishes a three-step framework for evaluating voltage sag performance of a distribution network. The first step, designated as state selection, is to select a network state in which voltage sag is likely. Although voltage sags have various causes, those that originated from faults in distribution networks are considered in this paper. The stochastic nature of fault location, type, resistance, and duration as well as the response of the protection system are taken into account. The second step, called state evaluation, deals with sag characteristics during the fault clearing time and the protection system response. The third step, named index calculation, is to estimate indices reflecting the sag performance of the network. A number of indices are proposed in this paper to reflect both system and load point-oriented issues. In light of the indices, companies may find effective solutions for voltage sag mitigation and customers choose appropriate solutions to provide ride-through support for their critical processes.
An Open Source GIS-Based Application for the Assessment of Groundwater Vulnerability to Pollution
Authors: Duarte Lia , Espinha Marques Jorge , Teodoro Ana Cláudia
Published: July 2019

Groundwater is a crucial natural resource for regular socio-economic function. Groundwater vulnerability to pollution can be assessed through Geographical Information System (GIS)-based qualitative methods. GIS-based tools, dedicated to the assessment of groundwater vulnerability, usually present several limitations, such as high cost, unavailable code, and a lack of functionality concerning the flexible application of vulnerability indices and vulnerability map comparison. The objective of this work was to create a new GIS-based open source application for groundwater vulnerability assessment, GVTool, developed using QGIS software, with the capability of creating and comparing groundwater vulnerability maps considering four different methods: DRASTIC, GOD, SINTACS, and Susceptibility Index (SI). This application incorporates features from a previous tool, DRASTIC Model, and new functionalities were included, namely three additional vulnerability assessment methods, map comparative analysis, map statistics, and index interval reclassification and symbology definition. The GVTool functionalities and capabilities are illustrated through a groundwater vulnerability assessment in Serra da Estrela mountain (Central Portugal). GVTool is mostly useful in integrated assessments, helping to verify if the groundwater vulnerability maps are accurate and to decide which is the most suitable method or the combination of methods to express groundwater vulnerability to pollution in a specific area.
Multi-Functional Electrospun Nanofibers from Polymer Blends for Scaffold Tissue Engineering
Authors: Nagam Hanumantharao Samerender , Rao Smitha
Published: July 2019

Electrospinning and polymer blending have been the focus of research and the industry for their versatility, scalability, and potential applications across many different fields. In tissue engineering, nanofiber scaffolds composed of natural fibers, synthetic fibers, or a mixture of both have been reported. This review reports recent advances in polymer blended scaffolds for tissue engineering and the fabrication of functional scaffolds by electrospinning. A brief theory of electrospinning and the general setup as well as modifications used are presented. Polymer blends, including blends with natural polymers, synthetic polymers, mixture of natural and synthetic polymers, and nanofiller systems, are discussed in detail and reviewed.
Prevalence and Toxicity Characterization of Bacillus cereus in Food Products from Poland
Authors: Berthold-Pluta Anna , Pluta Antoni , Garbowska Monika , Stefańska Ilona
Published: July 2019

The prevalence of Bacillus cereus in a total of 585 samples of food products (herbs and spices, breakfast cereals, pasta, rice, infant formulas, pasteurized milk, fresh acid and acid/rennet cheeses, mold cheeses and ripening rennet cheeses) marketed in Poland was investigated. The potential of 1022 selected isolates of B. cereus to hydrolyze casein, starch and tributyrin, to ferment lactose, to grow at 7 °C/10 days, to produce Nhe and Hbl toxin and to possess the ces gene was verified. B. cereus was found in 38.8% of the analyzed samples, reaching levels from 0.3 to 3.8 log CFU g−1 or mL−1. From the 1022 isolates, 48.8%, 36.0%, 98.9%, 80.0% and 25.0% were capable of fermenting lactose, producing amylase, protease, lipase and growing at 7 °C/10 days, respectively, indicating spoilage potentiality. The occurrence of toxigenic B. cereus strains in all tested market products, both of plant (55.8% Hbl(+), 70.7% Nhe(+) and 1.7% ces(+) isolates) and animal origin (84.9% Hbl(+), 82.7% Nhe(+) and 0.9% ces(+) isolates) indicates the possible risk of foodborne infections/intoxications that occur as a result of the possibility of the development of B. cereus in favorable conditions and consumption of these products.
Dispersive Solid–Liquid Extraction Coupled with LC-MS/MS for the Determination of Sulfonylurea Herbicides in Strawberries
Authors: Song Nho-Eul , Seo Dong-Ho , Choi Ji Yeon , Yoo Miyoung , Koo Minseon , Nam Tae Gyu
Published: July 2019

The monitoring of food quality and safety requires a suitable analytical method with simultaneous detection in order to control pesticide and herbicide residues. In this study, a novel analytical method, referred to as “dispersive solid–liquid extraction”, was applied to monitor seven sulfonylurea herbicides in strawberries. This method was optimized in terms of the amount of C18 and the volume of added water, and it was validated through satisfactory linearities (R2 > 0.99), recoveries of 70% to 84% with acceptable precisions, and limits of quantification lower than the maximum residue limits for the seven sulfonylurea herbicides in strawberries. The cleanup efficiency of the dispersive solid–liquid extraction technique was compared to that of the QuEChERS- (“quick, easy, cheap, effective, rugged and safe”) based method with dispersive solid phase extraction. The recoveries of the former were found to be comparable to those involving QuEChERS C18 cleanup (recoveries of 74%–87%). The method was used to determine sulfonylurea herbicide residues in ten strawberry samples. None of the samples had herbicide residues higher than that of limit of quantifications (LOQs) or maximum residue limits (MRLs). The results suggest that the dispersive solid–liquid extraction method combined with liquid chromatography-tandem mass spectrometry (LC-MS/MS) is effective for the analysis of sulfonylurea herbicide residues in strawberries.
Anthropometric Indices and Some Aspects of Physical Fitness in Croatian Adolescents by Gender
Authors: Zvonar Martin , Kasović Mario , Štefan Lovro
Published: July 2019

Background. The main purpose of this study was to explore the body-mass index and waist circumference associated with physical fitness by gender. Methods. In this cross-sectional study, we included 1036 adolescents (55.4% girls) from eight randomly selected secondary schools within the city of Zagreb (Croatia). Body-mass index and waist circumference were objectively measured. Physical fitness included three tests: (1) 1 min sit-ups, (2) standing long jump and (3) a sit-and-reach test. Associations were calculated using linear regression models. Results. Boys had higher body-mass index and waist circumference values, compared to girls (p < 0.001). They also performed better in 1 min sit-ups and the standing long jump tests (p < 0.001), while girls obtained higher values in the sit-and-reach test (p < 0.001). In boys, body-mass index and waist circumference were associated with 1 min sit-ups and the standing long jump. In girls, waist circumference was also associated with 1 min sit-ups and the standing long jump, while body-mass index was only associated with this standing long jump. Conclusions. Our study shows that anthropometric indices have non-linear associations with physical fitness tests in a large sample of Croatian adolescents. Screening for thinness and obesity to predict the level of physical fitness should be of a great interest.
Prevalence, Related Factors, and Levels of Burnout Syndrome Among Nurses Working in Gynecology and Obstetrics Services: A Systematic Review and Meta-Analysis
Authors: De la Fuente-Solana Emilia I. , Suleiman-Martos Nora , Pradas-Hernández Laura , Gomez-Urquiza Jose L. , Cañadas-De la Fuente Guillermo A. , Albendín-García Luis
Published: July 2019

Background: Although burnout levels and the corresponding risk factors have been studied in many nursing services, to date no meta-analytical studies have been undertaken of obstetrics and gynecology units to examine the heterogeneity of burnout in this environment and the variables associated with it. In the present paper, we aim to determine the prevalence, levels, and related factors of burnout syndrome among nurses working in gynecology and obstetrics services. Methods: A systematic review and meta-analysis of the literature were carried out using the following sources: CINAHL (Cumulative Index of Nursing and Allied Health Literature), LILACS (Latin American and Caribbean Health Sciences Literature), Medline, ProQuest (Proquest Health and Medical Complete), SciELO (Scientific Electronic Library Online), and Scopus. Results: Fourteen relevant studies were identified, including, for this meta-analysis, n = 464 nurses. The following prevalence values were obtained: emotional exhaustion 29% (95% CI: 11–52%), depersonalization 19% (95% CI: 6–38%), and low personal accomplishment 44% (95% CI: 18–71%). The burnout variables considered were sociodemographic (age, marital status, number of children, gender), work-related (duration of the workday, nurse-patient ratio, experience or number of miscarriages/abortions), and psychological (anxiety, stress, and verbal violence). Conclusion: Nurses working in obstetrics and gynecology units present high levels of burnout syndrome. In over 33% of the study sample, at least two of the burnout dimensions considered are apparent.
Association of Access to Healthcare with Self-Assessed Health and Quality of Life among Old Adults with Chronic Disease in China: Urban Versus Rural Populations
Authors: Zhang Tao , Liu Chaojie , Ni Ziling
Published: July 2019

This study examined urban–rural differences in the association of access to healthcare with self-assessed health and quality of life (QOL) among old adults with chronic diseases (CDs) in China. The data of 5796 older adults (≥60) with self-reported CDs were collected from the Study on Global Ageing and Adult Health in China, including indicators of self-assessed health and QOL and information on access to healthcare. Associations of access to healthcare with self-assessed health and QOL at the 10th, 50th, and 90th conditional quantiles were determined after controlling individual and household factors, showing that urban patients who received healthcare within two weeks gave higher ratings on self-assessed health scores at the 10th and 50th quantiles. In rural areas, one-year and two-week access to healthcare was found to be associated with QOL scores at the 10th and 90th quantiles, respectively. Marginal effects of using needed health service decreased with a growth in QOL and self-assessed health scores in both urban and rural locations despite these effects being significant across the whole distribution. Overall, access to healthcare affects the self-assessed health and QOL of the elderly with CDs in China, especially in patients with poor health, though differently for urban and rural patients. Policy actions targeted at vulnerable and rural populations should give priority to reducing barriers to seeking health services.
Dose–Response Relationship of Outdoor Exposure and Myopia Indicators: A Systematic Review and Meta-Analysis of Various Research Methods
Authors: Ho Ciao-Lin , Wu Wei-Fong , Liou Yiing Mei
Published: July 2019

Myopia in children has dramatically increased worldwide. A systematic review and meta-analysis were conducted to evaluate the effects of outdoor light exposure on myopia. According to research data from 13 studies of 15,081 children aged 4–14 at baseline, outdoor light exposure significantly reduced myopia incidence/prevalence (odds ratio [OR] = 0.85, 95% confidence interval [CI]: 0.80–0.91, p < 0.00001; I2 = 90%), spherical equivalent refractive error (SER) by 0.15 D/year (0.09–0.27, p < 0.0001), and axial elongation by 0.08 mm/year (−0.14 to −0.02, p = 0.02). The benefits of outdoor light exposure intervention, according to pooled overall results, included decreases in three myopia indicators: 50% in myopia incidence, 32.9% in SER, and 24.9% in axial elongation for individuals in Asia. Daily outdoor light exposure of more than 120 min was the most effective intervention, and weekly intervention time exhibited a dose–response relationship with all three indicators. Subgroup comparisons revealed that interventional studies report greater benefits from outdoor light exposure compared with cohort and cross-sectional studies, and individuals with myopia in intervention studies experienced slightly greater benefits than individuals without, in terms of SER and axial elongation. Therefore, this study suggests 120 min/day of outdoor light exposure at school.
The Actual Demand for the Elimination of Architectural Barriers among Senior Citizens in Poland
Authors: Kurtyka-Marcak Izabela , Hełdak Maria , Przybyła Katarzyna
Published: July 2019

The purpose of the study is to determine the actual demand for the elimination of architectural barriers among senior citizens in their place of residence and also in its immediate environment in Poland. The research covered a group of people in the post-productive age, living in the Lower Silesia voivodship in Poland. Different research methods were used in the study, primarily including the public opinion survey based on a questionnaire as well as statistical analyses. The cross-tabulation analysis of differences in quality characteristics was performed using Pearson’s chi-square test (χ2 test of independence) or Fisher’s exact test, when the expected number was lower than five. As a post hoc analysis, checking the nature of differences between the studied groups, the analyses were carried out using the method by Baesley and Schumacker. For all analyses, the maximum permissible error class I α = 0.05 was adopted, whereas p ≤ 0.05 was considered statistically significant. The research revealed that a much larger group of people aged 55 and older suffers from mobility limitations than the ones resulting from disability certificates, thus confirming the assumption that along with the respondents’ age, their mobility limitations intensify, resulting in the need for assistance while moving outside their houses/apartments.
The Disparity in Mental Health Between Two Generations of Internal Migrants (IMs) in China: Evidence from A Nationwide Cross-Sectional Study
Authors: Chen Wen , Zhang Qi , Renzaho Andre M.N. , Ling Li
Published: July 2019

Background: Internal migrants (IMs) are a large, vulnerable population in China and are mostly driven by national economic reform. IMs who were born before and after 1980, when the general social and economic reform began to appear in China, are considered to be two separate generations. The generational differences in mental health across IMs remain undocumented. In this study, the intergenerational disparity in IMs’ mental health, using data from a national cross-sectional study, was assessed. Methods: Cross-sectional data from the “National Internal Migrant Dynamic Monitoring Survey 2014” were used. IMs were divided into the “old” or “new” generation, based on their date of birth (before 1980 vs. from 1980 onwards). Mental health includes psychological distress, which was measured using the Kessler Screening Scale for Psychological Distress (K6), and perceived stress, which was measured with the Perceived Stress Scales (PSS-4). Two-level Generalized Linear Mixed Models were performed so as to assess the generation gap and associated factors of each group’s mental health. IM demographics, migration characteristics, and social integration indicators were controlled for when assessing the intergenerational disparity in mental health. Results: A total of 15,999 IMs from eight different cities participated in the survey. New generation migrants accounted for 61.5% (9838/15,999) of the total sample. After controlling for participants’ characteristics, new generation migrants had higher psychological distress scores (βad = 0.084, 95% CI: (0.026,0.193) and higher perceived stress scores (βad = 0.118, 95% CI: 0.029, 0.207) than the older generation. For both generations, factors associated with good mental health included high levels of social integration, personal autonomy, and life satisfaction, as well as self-rated good physical health. For the new generation, the mental health of urban-to-urban IMs (βad = 0.201, 95%CI: 0.009, 0.410) for the K6, βad = 0.241, 95% CI: 0.073, 0.409 for the PSS-4), IMs with a longer migration duration (βad = 0.002, 95% CI: (0.000, 0.003) for the PSS-4) and IMs with a higher annual income (βad = 0.124, 95% CI: (0.029, 0.218) for the K6) was significantly poorer than their counterparts. Conclusions: New-generation migrants’ mental health is worse compared to older IMs. An array of services for addressing these generation-specific needs may facilitate the promotion of mental health among IMs in China.
Rural Households’ Poverty and Relocation and Settlement: Evidence from Western China
Authors: Liu Wei , Xu Jie , Li Jie , Li Shuzhuo
Published: July 2019

Based on survey data collected from five counties across southern Shaanxi, China, the present study employs a multinomial logistic model to explore the main factors related to the type of poverty of rural households, particularly focusing on the role of relocation time, reason for relocation, and type of relocation. The results showed that three types of poverty, “voluntary poverty”, “transient poverty”, and “chronic poverty”, are distinguished by combining income and consumption criteria. Moreover, relocation and settlement programs contribute to a certain degree to these three kinds of poverty, and the effects vary according to the relocation characteristics. Specifically, those relocated long-term were more likely to be trapped in “voluntary poverty” and “chronic poverty”, whereas those relocated short-term were less likely to fall into “voluntary poverty” and “transient poverty”. The poverty alleviation and disaster-related resettlers were less likely to be trapped in “chronic poverty”, whereas centralized resettlers were less likely to be trapped in “voluntary poverty” and “chronic poverty”. Additionally, demographic characteristics, capital endowment variables, and geographical features are all important factors affecting rural households’ type of poverty. This study can serve as a reference for further resettlement practice in China and other developing countries.
COMET’s Education and Training for the Worldwide Meteorological Satellite User Community: Meeting Evolving Needs with Innovative Instruction
Authors: Dills Patrick , Stevermer Amy , Mancus Tony , Guarente Bryan , Alberta Tim , Page Elizabeth
Published: July 2019

Since 1989, the COMET® Program’s staff of instructional designers, scientists, graphic artists, and web developers has been creating targeted, effective, and scientifically sound instructional materials for the geosciences in multiple languages and formats. The majority of COMET training materials and services are available via COMET’s online training portal, MetEd. MetEd hosts over 500 self-paced English-language lessons, which are freely available to registered users. The lessons cover a broad array of topics, including satellite meteorology, numerical weather prediction, hydrometeorology, oceanography, aviation weather, climate science, and decision support. Nearly 300 lessons have been translated to other languages. NOAA NESDIS, EUMETSAT, the Meteorological Service of Canada, and the US National Weather Service all provide funding and subject matter expertise for satellite training efforts at COMET. The COMET team is focused on helping our sponsors refine their learning objectives and produce instructional material that is focused on learner engagement, knowledge retention, and measurable performance improvement. The COMET Program has continually transformed its instructional approach to better meet the shifting needs of learners. Our satellite remote sensing educational and training materials provide sound foundational knowledge for existing and new satellite products paired with increasing opportunities to apply that knowledge.
Genetic Associations between Voltage-Gated Calcium Channels and Psychiatric Disorders
Authors: Andrade Arturo , Brennecke Ashton , Mallat Shayna , Brown Julian , Gomez-Rivadeneira Juan , Czepiel Natalie , Londrigan Laura
Published: July 2019

Psychiatric disorders are mental, behavioral or emotional disorders. These conditions are prevalent, one in four adults suffer from any type of psychiatric disorders world-wide. It has always been observed that psychiatric disorders have a genetic component, however, new methods to sequence full genomes of large cohorts have identified with high precision genetic risk loci for these conditions. Psychiatric disorders include, but are not limited to, bipolar disorder, schizophrenia, autism spectrum disorder, anxiety disorders, major depressive disorder, and attention-deficit and hyperactivity disorder. Several risk loci for psychiatric disorders fall within genes that encode for voltage-gated calcium channels (CaVs). Calcium entering through CaVs is crucial for multiple neuronal processes. In this review, we will summarize recent findings that link CaVs and their auxiliary subunits to psychiatric disorders. First, we will provide a general overview of CaVs structure, classification, function, expression and pharmacology. Next, we will summarize tools to study risk loci associated with psychiatric disorders. We will examine functional studies of risk variations in CaV genes when available. Finally, we will review pharmacological evidence of the use of CaV modulators to treat psychiatric disorders. Our review will be of interest for those studying pathophysiological aspects of CaVs.
Multiscale Molecular Dynamics Simulation of Multiple Protein Adsorption on Gold Nanoparticles
Authors: Tavanti Francesco , Pedone Alfonso , Menziani Maria Cristina
Published: July 2019

A multiscale molecular dynamics simulation study has been carried out in order to provide in-depth information on the adsorption of hemoglobin, myoglobin, and trypsin over citrate-capped AuNPs of 15 nm diameter. In particular, determinants for single proteins adsorption and simultaneous adsorption of the three types of proteins considered have been studied by Coarse-Grained and Meso-Scale molecular simulations, respectively. The results, discussed in the light of the controversial experimental data reported in the current experimental literature, have provided a detailed description of the (i) recognition process, (ii) number of proteins involved in the early stages of corona formation, (iii) protein competition for AuNP adsorption, (iv) interaction modalities between AuNP and protein binding sites, and (v) protein structural preservation and alteration.
Do DLX3 and CD271 Protect Human Keratinocytes from Squamous Tumor Development?
Authors: Palazzo Elisabetta , Marconi Alessandra , Pincelli Carlo , Morasso Maria I.
Published: July 2019

Well-regulated epidermal homeostasis depends on the function of different classes of factors, such as transcription regulators and receptors. Alterations in this homeostatic balance may lead to the development of cutaneous squamous tumorigenesis. The homeobox transcription factor DLX3 is determinant for a p53-dependent regulation of epidermal differentiation and modulates skin carcinogenesis. The maintenance of skin homeostasis also involves the action of neurotrophins (NTs) and their receptors, Trk and CD271. While Trk receptor overexpression is a hallmark of cancer, there are conflicting data on CD271 expression and function in cutaneous SCC (cSCC). Previous studies have reported NT receptors expression in head and neck SSC (HNSCC). We show that CD271 is expressed at low levels in primary cSCC cells and the number of CD271+ cells correlates with cell cohesion in SCC spheroids. In normal epidermis, CD271 is expressed in proliferative progenitor cells and DLX3 in terminally differentiated keratinocytes. Brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT3) increase DLX3 expression. In the absence of a functional BDNF receptor TrkB in keratinocytes, we hypothesize that the BDNF-dependent DLX3 response could be mediated via CD271. Altogether, our results support a putative CD271-DLX3 connection in keratinocytes, which might be crucial to preventing squamous skin cancer.
Age-Dependent Levels of Protein Kinase Cs in Brain: Reduction of Endogenous Mechanisms of Neuroprotection
Authors: Pastore Donatella , Pacifici Francesca , Dave Kunjan R. , Palmirotta Raffaele , Bellia Alfonso , Pasquantonio Guido , Guadagni Fiorella , Donadel Giulia , Di Daniele Nicola , Abete Pasquale , Lauro Davide , Rundek Tatjana , Perez-Pinzon Miguel A. , Della-Morte David
Published: July 2019

Neurodegenerative diseases are among the leading causes of mortality and disability worldwide. However, current therapeutic approaches have failed to reach significant results in their prevention and cure. Protein Kinase Cs (PKCs) are kinases involved in the pathophysiology of neurodegenerative diseases, such as Alzheimer’s Disease (AD) and cerebral ischemia. Specifically ε, δ, and γPKC are associated with the endogenous mechanism of protection referred to as ischemic preconditioning (IPC). Existing modulators of PKCs, in particular of εPKC, such as ψεReceptor for Activated C-Kinase (ψεRACK) and Resveratrol, have been proposed as a potential therapeutic strategy for cerebrovascular and cognitive diseases. PKCs change in expression during aging, which likely suggests their association with IPC-induced reduction against ischemia and increase of neuronal loss occurring in senescent brain. This review describes the link between PKCs and cerebrovascular and cognitive disorders, and proposes PKCs modulators as innovative candidates for their treatment. We report original data showing εPKC reduction in levels and activity in the hippocampus of old compared to young rats and a reduction in the levels of δPKC and γPKC in old hippocampus, without a change in their activity. These data, integrated with other findings discussed in this review, demonstrate that PKCs modulators may have potential to restore age-related reduction of endogenous mechanisms of protection against neurodegeneration.
Genomic Organization of Repetitive DNA Elements and Extensive Karyotype Diversity of Silurid Catfishes (Teleostei: Siluriformes): A Comparative Cytogenetic Approach
Authors: Ditcharoen Sukhonthip , Antonio Carlos Bertollo Luiz , Ráb Petr , Hnátková Eva , Franco Molina Wagner , Liehr Thomas , Tanomtong Alongklod , Triantaphyllidis Costas , Ozouf-Costaz Catherine , Tongnunui Sampan , Pengseng Puan , Supiwong Weerayuth , Aroutiounian Rouben , de Bello Cioffi Marcelo
Published: July 2019

The catfish family Siluridae contains 107 described species distributed in Asia, but with some distributed in Europe. In this study, karyotypes and other chromosomal characteristics of 15 species from eight genera were examined using conventional and molecular cytogenetic protocols. Our results showed the diploid number (2n) to be highly divergent among species, ranging from 2n = 40 to 92, with the modal frequency comprising 56 to 64 chromosomes. Accordingly, the ratio of uni- and bi-armed chromosomes is also highly variable, thus suggesting extensive chromosomal rearrangements. Only one chromosome pair bearing major rDNA sites occurs in most species, except for Wallago micropogon, Ompok siluroides, and Kryptoterus giminus with two; and Silurichthys phaiosoma with five such pairs. In contrast, chromosomes bearing 5S rDNA sites range from one to as high as nine pairs among the species. Comparative genomic hybridization (CGH) experiments evidenced large genomic divergence, even between congeneric species. As a whole, we conclude that karyotype features and chromosomal diversity of the silurid catfishes are unusually extensive, but parallel some other catfish lineages and primary freshwater fish groups, thus making silurids an important model for investigating the evolutionary dynamics of fish chromosomes.
Alteration of the Total Cellular Glycome during Late Differentiation of Chondrocytes
Authors: Homan Kentaro , Hanamatsu Hisatoshi , Furukawa Jun-ichi , Okada Kazue , Yokota Ikuko , Onodera Tomohiro , Iwasaki Norimasa
Published: July 2019

In normal articular cartilage, chondrocytes do not readily proliferate or terminally differentiate, and exhibit a low level of metabolism. Hypertrophy-like changes of chondrocytes have been proposed to play a role in the pathogenesis of osteoarthritis by inducing protease-mediated cartilage degradation and calcification; however, the molecular mechanisms underlying these changes are unclear. Glycans are located on the outermost cell surface. Dynamic cellular differentiation can be monitored and quantitatively characterized by profiling the glycan structures of total cellular glycoproteins. This study aimed to clarify the alterations in glycans upon late differentiation of chondrocytes, during which hypertrophy-like changes occur. Primary mouse chondrocytes were differentiated using an insulin-induced chondro-osteogenic differentiation model. Comprehensive glycomics, including N-glycans, O-glycans, free oligosaccharides, glycosaminoglycan, and glycosphingolipid, were analyzed for the chondrocytes after 0-, 10- and 20-days cultivation. The comparison and clustering of the alteration of glycans upon hypertrophy-like changes of primary chondrocytes were performed. Comprehensive glycomic analyses provided complementary alterations in the levels of various glycans derived from glycoconjugates during hypertrophic differentiation. In addition, expression of genes related to glycan biosynthesis and metabolic processes was significantly correlated with glycan alterations. Our results indicate that total cellular glycan alterations are closely associated with chondrocyte hypertrophy and help to describe the glycophenotype by chondrocytes and their hypertrophic differentiation. our results will assist the identification of diagnostic and differentiation biomarkers in the future.
Plasticity of High-Density Neutrophils in Multiple Myeloma is Associated with Increased Autophagy Via STAT3
Authors: Puglisi Fabrizio , Parrinello Nunziatina , Giallongo Cesarina , Cambria Daniela , Camiolo Giuseppina , Bellofiore Claudia , Conticello Concetta , Del Fabro Vittorio , Leotta Valerio , Markovic Uros , Sapienza Giuseppe , Barbato Alessandro , Scalese Silvia , Tibullo Daniele , Brundo Maria , Palumbo Giuseppe , Di Raimondo Francesco , Romano Alessandra
Published: July 2019

In both monoclonal gammopathy of uncertain significance (MGUS) and multiple myeloma (MM) patients, immune functions are variably impaired, and there is a high risk of bacterial infections. Neutrophils are the most abundant circulating leukocytes and constitute the first line of host defense. Since little is known about the contribution of autophagy in the neutrophil function of MGUS and MM patients, we investigated the basal autophagy flux in freshly sorted neutrophils of patients and tested the plastic response of healthy neutrophils to soluble factors of MM. In freshly sorted high-density neutrophils obtained from patients with MGUS and MM or healthy subjects, we found a progressive autophagy trigger associated with soluble factors circulating in both peripheral blood and bone marrow, associated with increased IFNγ and pSTAT3S727. In normal high-density neutrophils, the formation of acidic vesicular organelles, a morphological characteristic of autophagy, could be induced after exposure for three hours with myeloma conditioned media or MM sera, an effect associated with increased phosphorylation of STAT3-pS727 and reverted by treatment with pan-JAK2 inhibitor ruxolitinib. Taken together, our data suggest that soluble factors in MM can trigger contemporary JAK2 signaling and autophagy in neutrophils, targetable with ruxolitinib.
Complement System in Cutaneous Squamous Cell Carcinoma
Authors: Riihilä Pilvi , Nissinen Liisa , Knuutila Jaakko , Rahmati Nezhad Pegah , Viiklepp Kristina , Kähäri Veli-Matti
Published: July 2019

Epidermal keratinocyte-derived cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer with high mortality rates in the advanced stage. Chronic inflammation is a recognized risk factor for cSCC progression and the complement system, as a part of innate immunity, belongs to the microenvironment of tumors. The complement system is a double-edged sword in cancer, since complement activation is involved in anti-tumor cytotoxicity and immune responses, but it also promotes cancer progression directly and indirectly. Recently, the role of several complement components and inhibitors in the regulation of progression of cSCC has been shown. In this review, we will discuss the role of complement system components and inhibitors as biomarkers and potential new targets for therapeutic intervention in cSCC.