bluuebunny/crossref_metadata_2025 huggingface dataset:
ФРАЗЕОЛОГІЗМИ У ПРОЦЕСІ ВИКЛАДАННЯ УГОРСЬКОЇ МОВИ ЯК ІНОЗЕМНОЇ
Authors: ТАЛАБІРЧУК Оксана
Published: April 2023

У статті розглядається не зʼясоване досі мовознавче питання – роль фразеологізмів у процесі викладання угорської мови як іноземної. Відзначено важливість фразеологізмів під час вивчення мови як іноземної, адже вони виражають духовне надбання кожного народу, виступають своєрідними представниками лінгвокультури, розширюють словник студента, сприяють розвитку інтересу до вивчення іноземної мови, формують уміння розуміти зміст автентичних текстів. У звʼязку з актуальністю вивчення угорської мови студентами у ВНЗ зросла потреба і в осмисленні фразеологізмів у процесі опанування угорської мови як іноземної, зокрема їхньої ролі у формуванні в українськомовного студента комунікативної компетенції.Аналіз досліджень засвідчив, що питання залучення фразеологічних одиниць (далі – ФО) у процес викладання угорської мови як іноземної ні в угорській, ні в українській лінгводидактиці ще не ставало предметом окремого дослі- дження. Детально у статті розглянуто класифікації фразеологізмів, розроблені Ш. Кароєм, Л. Гадровичем та Я. Жемʼєі. Саме класифікація останнього вченого взята за основу під час вибору ФО, що рекомендуються до вивчення. Також узя- то до уваги рекомендаціяї Б. Ґіоі стостовно необхідності на початковому етапі вивчення мови засвоєння граматичних форм ФО як лексичних, тобто без жодного граматичного пояснення.У статті обґрунтовано необхідність формування фразеологічного мінімуму як складника угорської лінгводидак- тики, зокрема під час викладання угорської мови як іноземної. Розглянуто можливий метод вивчення ФО – навчальні картки, а також звернено увагу на важливість включення фразеологічного матеріалу у вправи та тексти, які даються студентам для опрацювання. Наголошено на доцільності поступового, поетапного введення фразеологізмів до словникового запасу студентів із розрахунку на 15 лексичних одиниць вивчати 1 фразеологізм. Запропоновано перелік фразе- ологізмів для вивчення на початковому етапі засвоєння угорської мови, на рівні володіння «елементарний користувач».
ФРАЗЕОЛОГІЗОВАНІ ПИТАЛЬНІ КОМУНІКАТИ В ДІАЛОГІЧНОМУ ДИСКУРСІ
Authors: ШАБАТ-САВКА Світлана
Published: April 2023

Прагнення до успішної вербалізації комунікативних інтенцій стимулює мовця як основного субʼєкта комунікації, як представника тієї або тієї етнокультури й лінгвоментальності до пошуку адекватних мовних засобів, що відповідають його намірам та вподобанням. У статті проаналізовано питальні речення фразеологізованої структури, що слугують оптимальними маркерами вираження мовленнєвих інтенцій, увиразнюють субстанцію українського мовця і за своєю синтаксичною природою становлять ідіоматичні побудови, особливі формули-реакції та моделі кому- нікування в діалогічному дискурсі.За допомогою лінгвістичної методології інвентаризовано значний за обсягом українськомовний матеріал й обґрунтовано релевантність двох основних моделей функціювання фразеологізованих питальних комунікатів у діалогічному дискурсі, зокрема постульовано думку про те, що фразеологізовані питальні комунікати як ідіоматичні конструкції реалі- зують інтенції запиту й виражають низку комунікативно-прагматичних функцій (ствердження, заперечення, емоційність, оцінка), створюючи експресивність, динамічність та природність діалогічного способу людської інтеракції.На ілюстративному матеріалі здійснено аналіз фразеологізованих питальних компонентів із факультативним, лексично змінним компонентом, що їх використовують мовці для зʼясування певної інформації, для вербалізації ін- тенцій ствердження чи заперечення, для репрезентації аксіологічно-емоційних настанов мовця; зазначено, що модель (фразеологізований маркер і лексично змінний повнозначний компонент) є амбівалентною з огляду на реалізацію інтенцій (питальних і непитальних значень).Йдеться і про вигукові фразеологізовані комунікати, що функціюють у діалогічному дискурсі як застиглі, нечленовані формули-реакції на висловлення адресанта й увиразнюють широкий комунікативно-інтенційний зміст: згоду, здивування, захоплення, байдужість, обурення тощо.Обґрунтовано думку про те, що в діалогічному дискурсі фразеологізовані питальні комунікати відображають перебіг толерантної / атолерантної (конфліктної) комунікації й виокремлюють та характеризують мовця як репрезентанта української лінгвоментальності й культури.
Mondros Mütarekesi’nden Lozan Antlaşması’na Türk-Fransız İlişkileri
Authors: Demir Enes Mert
Published: April 2023

Osmanlı Devleti ve Fransa arasında esas olarak 16. yüzyılda başlayan ve dostane şekilde devam eden ikili münasebetler, Birinci Dünya Savaşı’na kadar gâh olumlu gâh olumsuz bir çerçevede seyretmiştir. Savaşa gelindiğinde ise Fransa, Osmanlı Devleti ile karşıt saflarda yer almıştır. Neticede savaşın galibi olan Fransa; İngiltere ile yaptığı gizli paylaşım mutabakatlarına göre Anadolu’nun güneyindeki birçok bölgeyi işgal etmiştir. Fransız işgaline karşı bölgede Millî Mücadele Harekâtı başlatılmış; Türk ve Fransız birlikleri arasında çok sayıda çarpışma ve muharebe yaşanmıştır. Millî Mücadele karşısında ağır kayıplar vermesi, Suriye’deki kazanımlarını kaybetme riski, bunun yanı sıra müttefiki İngiltere’yle bazı anlaşmazlıklar yaşaması Fransa’yı Ankara Hükûmetiyle uzlaşı arayışına yöneltmiştir.
İki ülke ilişkilerini bu dönemde, ayrıca Sevr, Mudanya ve Lozan Konferansı süreçlerinde yaşanan gelişmeler ile tarafların tartışmalı meselelerdeki tutum ve istekleri belirlemiştir. Neticede Lozan Antlaşmasıyla birçok problem çözüme kavuşturulmuş; Hatay meselesi gibi kritik bazı sorunlar istisna olmak üzere Türkiye-Fransa arasında kalıcı barış tesis edilmiştir.
Zikredilen malumattan hareketle makalenin konusunu, Mondros Mütarekesi’nden Lozan Antlaşması’na kadar olan dönemdeki Türk-Fransız ilişkileri oluşturmaktadır. İki ülke ilişkilerini bahsedilen süreçte etkileyen siyasi, askerî ve iktisâdi gelişmeler üzerinde durulmuş; yaşananlar iki taraf penceresinden karşılaştırmalı olarak ele alınmıştır. Nitel araştırma ve analiz yöntemiyle hazırlanan çalışmada TBMM Tutanakları Gizli Celse Zabıtları ile mevcut telif ve tercüme eserlerden istifade edilmiştir.
Kinetic Study of Ethanol Dehydration to Ethylene and Diethyl Ether in Catalytic Packed Bed Reactor Over ZSM-5 Catalyst
Authors: Aali Narin A. , Hadi Ghassan J.
Published: April 2023

Dehydration of ethanol is one of the crucial processes as it is considered a green route for producing ethylene and diethyl ether and is promoted mainly by economics and environmental appeal. In this study, different kinetic models for ethanol dehydration to ethylene and diethyl ether were developed based on two parallel reactions and different mechanisms. Additionally, a mathematical model of a packed bed reactor was also suggested based on a set of hypotheses for investigating the axial concentration profile of ethanol. Kinetic parameters of each model were estimated by nonlinear regression analysis of obtained experimental data reported in the literature at temperatures between (523.15 – 623.15) K. The analysis showed that the single-site model I for ethylene formation and dual-site (LHHW) model for diethyl ether formation gave the best representation of experimental data compared to other proposed models. Kinetic parameters were found to be in good accordance with the Arrhenius equation with acceptable straight-line plots, and they have been satisfactorily correlated as functions of reaction temperature. The mathematical model presented a smooth linear change in ethanol concentration at various temperatures. The AARD% obtained for each chosen ethylene and diethyl ether formation model were about (1.4502-2.5978) and (0.9135-2.9394), respectively.
Multi-Comfortable Urban Architectural Environment
Authors: Leshchenko Nellia , Holovatiuk Alina
Published: April 2023

The paper is aimed at defining a multi-comfortable urban architectural environment and strategies for achieving it during the restoration-reconstructive transformations of historical city centers. The definition of the “multi-comfortable urban architectural environment” is given. Its ten criteria are highlighted and recommendations are given for its achieverment. A model of a multi-comfortable historical urban environment has been developed, where its image (beauty) – function (interest) – infrastructure (convenience) – “urban performance” (activity), criteria for multi-comfort and key strategies suitable for improving each of the four components are interconnected. The developed model, the highlighted criteria for determining the multi-comfortable urban environment, and the proposed recommendations will be useful in the development of complex projects of restoration-reconstructive transformations of historical cities, as well as in the new design in them. It has been determined that a multi-comfortable urban architectural environment, where a person is in the main, should be the result of any restoration-reconstructive transformations of historical city centers.
Flying Robot Technology (Drone) Trends: A Review in the Building and Construction Industry
Authors: Takva Çağatay , İlerisoy Zeynep Yeşim
Published: April 2023

With the emergence of Industry 4.0, the use of robotic technologies is among today’s trends. The innovations that this revolution brought to robotic construction in the fields of communication, control, and software also improve flying robot technology. In the study, the place and importance of drone technology, which is one of the flying robot technologies at the intersection of Industry 4.0 and AEC (architecture, engineering, and construction) industry, in architecture is defined. The research aims to analyze the digital fabrication studies with drone technology in the field of architecture by reviewing the literature and to reveal how these applications are followed. Studies with drones, which are the technology of the future, are presented by creating a timeline. Drone studies in the building and construction industry were classified according to drone type, gripper and software features and comparative analyses were made. As a result, it is desired to show the development of drone technology in architecture, examine how it is used, and create a reference study in the light of existing examples for its use in future applications.
Impressing Your Journal Editor. Interview With Debi Brannan, PhD
Authors: Cannon Bradley
Published: April 2023

New and experienced journal authors alike can always improve their writing and publishing skills. Psi Chi Journal Editor Dr. Debi Brannan shares mistakes to avoid and tips to impress your editor.
Evaluation of Teacher Professional Development - International Experiences and Recommendations for Vietnam
Authors: Hoang Doan Huy Nguyen , Hai Pham Thi Thanh
Published: April 2023

Teacher professional development is considered as one of the important stages of improving the quality of education; Accordingly, teacher professional development assessment also needs to be researched and applied effectively to ensure its contribution to the improvement of teachers’ quality. This study uses the document analysis based on international articles retrieved from databases such as ScienceDirect, Scopus, Google Scholar... on the issue of teacher professional development assessment. Research results show that a number of works have proposed assessment standards, assessment forms and other recommendations necessary to help not only recognize the results of professional development that teachers achieve, thereby helping to further improve the respective professional development process. The analysis also shows that there is currently a major shortage in the development and validation of teacher professional development assessment toolkits, especially in the context of Vietnam. Based on the observations related to international practice on assessment and development of instruments to evaluate teacher professional development, the author proposes a number of recommendations to develop Vietnamese teacher professional development evaluation instruments.
IMPLEMENTASI BUDAYA SEKOLAH DALAM MEMBENTUK KARAKTER RELIGIUS PESERTA DIDIK DI SD NO. 6 BELOK KECAMATAN PETANG KABUPATEN BADUNG
Authors: Ari Armini Ni Made , Sujana, M.Pd Drs. I Made , Putra Aryana, M.Pd.H I Made
Published: April 2023

Abstrak: Sekolah merupakan tempat berlangsungnya pendidikan formal, sekolah tidak saja menjadi tempat guru menyampaikan berbagai mata pelajaran saja akan tetapi sekolah juga menjadi lembaga dalam pembentukan karaker. Suatu fenomena di SD No. 6 Belok diduga menerapkan budaya sekolah dalam membentuk karakter peserta didik sehingga layak diteliti. Adapun rumusan masalah yang dibahas ada 3 yaitu 1) bagaimanakah bentuk implementasi budaya sekolah dalam membentuk karakter religius peserta didik di SD No. 6 Belok Kecamatan Petang Kabupaten Badung? 2) upaya-upaya apa saja yang dilakukan dalam membentuk karakter religius peserta didik di SD No. 6 Belok Kecamatan Petang Kabupaten Badung? 3) Bagaimanakah dampak implementasi budaya sekolah dalam membentuk karakter religius peserta didik di SD No. 6 Belok Kecamatan Petang Kabupaten Badung. Teori yang digunakan 1) Teori behaviorisme, 2) Teori motivasi. Jenis penelitian menggunakan kualitatif pendekatan deskriptif. Metode pengumpulan data dengan observasi, wawancara, dokumentasi dan studi kepustakaan. Teknik penenuan informan dengan purposive sampling. Teknik pengecekan keabsaahan data 1) credibility, 2) transferability, 3) dependability, 4) confirmability. Analisis data dengan 1) data reduction/reduksi, data, 2) data display/penyajian data, 3) conclusion/kesimpulan.

Hasil penelitian 1) Bentuk implementasi budaya sekolah dalam membentuk karakter peserta didik melalui pembiasaan (1) melaksanakan persembahyangan di kelas, (2) memperingati hari besar keagamaan, (3) budaya 5S, (4) budaya jujur, (5) budaya persahabatan, (6) budaya toleransi, (7) budaya literasi, (8) budaya melaksanakan upacara bendera, (9) budaya peduli lingkungan sekolah, (10) ekstrakurikuler. 2) upaya-upaya yang dilakukan dalam membentuk karakter religius peserta didik melalui 3 upaya (1) upaya kepala sekolah, (2) upaya guru, (3) upaya peserta didik. 3) dampak implementasi budaya sekolah dalam membentuk karakter religius peserta didik (1) dampak bagi peserta didik, (2) dampak bagi guru, (3) dampak bagi sekolah, (4) dampak bagi lingkungan masyarakat.
UPAYA MENINGKATKAN MINAT BELAJAR SISWA HINDU PADA PASRAMAN GIRI AJI SENGKONGO KABUPATEN LOMBOK BARAT
Authors: Waemese Jeki , Putera Gusti Ngurah Ketut , Rudiarta I Wayan
Published: April 2023

This research is motivated by the phenomenon that the learning process that takes place at the Giri Aji Sengkongo pasraman is less attractive to students. Interest as a form of motivation should be an energy that is always present in an effort to improve the quality of education. Students' interest in learning is very important because without students' interest in participating in learning, the material provided will not arrive in its entirety. This study aims to reveal the factors causing the lack of interest in learning Hindu students at the Giri Aji Sengkongo pasraman and describe the efforts to increase the learning interest of Hindu students at the Giri Aji Sengkongo pasraman. This research is a qualitative research with data collection using non-participant observation techniques, structured interviews and documentation studies. The data that has been collected is then analyzed by means of data reduction, data verification, and conclusion drawing. The theory used in the data analysis of field findings is Maslow's theory of motivation. The research findings indicate that several factors cause the students' lack of interest in learning at the Giri Aji Sengkongo boarding school in the form of lack of infrastructure, students get bored quickly, monotonous learning methods, and lack of teaching staff. Furthermore, the efforts made to overcome this are teachers always motivating students, intensive communication between teachers and students' parents, giving pocket money, reward and punishment, requesting assistance, empowering stakeholders.
MEREKONSTRUKSI SIKLUS KEHIDUPAN SEBAGAI DAYA TARIK WISATA BUDAYA DI SAMSARA LIVING MUSEUM
Authors: Putu Guntur Pramana Putra  , Ni Nyoman Arini  , Komang Shintiya Nita Kristiana Putri
Published: April 2023

Cultural tourism is a type of tourism that specifically conserves the various resources it uses, namely tourism that develops culture in a sustainable manner. Bali has wealth in the form of a variety of cultural arts, customs and traditions, and religious procedures and their existence as a legacy from the past. Cultural arts in Bali can live and develop influenced by various religious ceremonial activities. This study analyzed the reconstructing the cycle of life as a cultural tourism attraction in the Samsara Living Museum. This study aims to find out the destination branding and the life cycle of the Balinese people which are appointed as the concept of this samsara living museum. Data were collected through observation, in-depth interviews, and literature study. The data analysis used is descriptive qualitative. This study concludes that the Samsara Living Museum has sparked destination branding and has implemented the reconstruction of the Balinese life cycle as a cultural tourism attraction.

Keywords : destination branding, balinese life cycle, samsara living museum
KONSEP JNANA YAJNA DALAM KAKAWIN SUTASOMA
Authors: Purwanto Heri , Titasari Coleta Palupi
Published: April 2023

Kajian ini bertujuan untuk mengungkapkan konsep jnana yajna yang terkandung dalam teks Kakawin Sutasoma. Data primer yang menjadi penelitian ini adalah Kakawin Sutasoma yang telah diterjemahkan oleh Mastuti dan Bramantyo (2019). Data primer dikaji dengan mengunakan analisis tekstual, lalu dalam interpretasi maknanya dibantu dengan sumber-sumber pendukung (data arkeologi). Berdasarkan hasil penelitian ini menunjukkan bahwa persembahan ilmu pengetahuan dapat dilakukan dengan cara belajar-mengajar dalam sebuah tempat pendidikan yang dinamakan dengan mandala kadewaguruan. Tempat-tempat pendidikan tersebut terletak di lereng-lereng gunung, lembah, sungai, dan perbukitan. Sebagaimana Sang Sutasoma mencari pengetahuan di Gunung Agung (Semeru), yang pada akhirnya menjadi seorang guru dan mengajarkan berbagai ajaran suci.
MODULATION STRATEGY IN TRANSLATING VERB PHRASES IN ENGLISH COOKBOOK INTO INDONESIAN
Authors: Kadek Ayu Ekasani
Published: April 2023

This research is focused on the modulation strategy in translating verb phrases in English cookbook into Indonesian. The data used in this study is taken from English cookbook entitled “The Essential Book of Sauces & Dressings” written by Murdoch Books and published by Periplus, Singapore and the translation into Indonesian entitled “Saus dan Dressing yang esensial” translated by Hadyana P. and published by Periplus, Indonesia. The main theory is adopted from the book “A Text book of Translation” by Newmark (1988) about the translation strategy. The methods that are used to collect data are documentation and observation. The results of this study not only found a number of independent modulation translation strategys, but there was also a combination of the modulation translation strategy with other strategys, including modulation and transposition; literal translation and modulation; modulation and reduction; transposition, modulation and calce; modulation, addition and transposition.
Russia's State Family Policy: Analysis of Current Legislation and Problematic Issues
Authors: Kravtsov Aleksey Yur'evich , Filimonov Arkadiy Dmitrievich
Published: April 2023

The subject of the study is the implementation of the state family policy in the Russian Federation, as an institution of family support, on the decent existence of which the functioning and development of any society and state directly depends. The authors consider in detail such aspects of the topic as the availability of a comprehensively elaborated regulatory framework as a foundation for the implementation of various measures laid down in the state family policy, including the provision of financial and economic measures aimed at supporting the family, as well as the preservation and strengthening of traditional family values (including countering the ideology of same-sex marriages, LGBT communities, childfree worldview, etc.). A special contribution of the authors to the study of the topic is the identification of legislative gaps in the regulation of certain types of family and legal relations, in particular in the regulation of marriage and family relations, countering the spread of same-sex marriages and sex change, as factors negatively affecting the strengthening and development of the family, the demographic situation in the Russian Federation. The result of the study is proposals to amend the current legislation of the Russian Federation regarding the grounds for refusal to register a marriage, invalidation of the marriage, as well as giving the prosecutor the authority to apply to the court with a statement of claim containing a requirement to recognize a marriage in which persons of the same sex are invalid. In addition, measures are proposed to strengthen counteraction to the propaganda of non-traditional views on gender identity (primarily among minors).
Revisiting Reentry Roll Resonance
Authors: Judd Stephen L.
Published: April 2023

This paper revisits the subject of reentry roll resonance, which occurs when the roll rate and pitch frequency become equal in a spinning reentry vehicle. A first-principles model is developed and analyzed numerically and by using a reduced-order pendulum model for the relative phase of the roll and pitch/yaw axes. The results show good qualitative agreement with recent flight data and provide a natural physical interpretation. Based on the model it is suggested that sustained roll resonance depends primarily on the initial phase relationship between the pitch and roll axes, in addition to the vehicle moments of inertia and the vehicle symmetry. Finally the model is used to propose a mechanism for sustained resonance in vehicles spinning about a major axis, a condition previously thought to be forbidden.
Mapping Relationships Between Airship Original Design and Stability Modes
Authors: Ge Yuyang , Wang Xiaoliang , Wang Quanbao
Published: April 2023

In this paper, we study the influence of an original airship design on its stability modes. Based on the verified model of the YEZ-2A airship, the Sobol sensitivities are calculated to filter the design parameters. The airship hull length, the slenderness ratio of the airship hull, the exponent of the tail, the fin installation position on the hull, and the fin half-span are found to be of large influences on all stability modes, whereas the stability modes are comparatively insensitive to the exponent of the bow and the fin relative thickness. The empirical formulas for mapping relationships are fitted to the experimental data and are verified by both sensitivities and root locus diagrams. The empirical formulas representing the mapping relationships between the original design parameters and the stability mode parameters of the airship can be used as references to simplify and estimate the stability and performance in the preliminary design of the airship.
FORMATION OF A CREDIT MECHANISM IN THE TRANSFORMATION PROCESSES CONDITIONS: SYSTEM ASPECTS
Authors:   State Biotechnological University, Vovk Viktoriia , Sadchykova Iryna ,   Chernihiv Polytechnic National University, Sadchykov Victor ,   Chernihiv Polytechnic National University
Published: April 2023

Within thearticle,theoretical aspects of the credit mechanism formation in the conditions of transformational changes according tothe system approachare substantiated. The purpose of the article is to deepen conceptual foundations of the formation and development of the credit mechanism in the context of crisis phenomena and transformational processes in economy. It has beennoted that the maximum effect from the management of financial resources can be obtained from their effective interaction in the field of the credit regulation mechanism. Only within the framework of such integration can the contradiction between the need for additional resources and their scarcity be resolved, so as not to disrupt continuity of the reproduction process. It has been substantiated that the presence of a common goal, paying attention to the complexity and systematicity of financial management create prerequisites for applying a systemic approach in the study of the credit mechanism. It has been noted that in the process of the credit mechanismfunctinongwith the condition of strengthening the processes of financial support, the resources of the state and local budgets, banking institutions, the parabanking sector, investors, as well as financial resources of the population for investing in socio-economic development programs at the macro and meso levels should be consolidated. Creation of the conditions for effective functioning of the credit mechanism, the development of the credit market and credit infrastructure requires the use of a complex system approach to overcome the problems of the shortage of funding sources. The main tasks, principles, elemental composition and characteristics of the credit mechanism has beendefined. The following factors influencing the mechanism functioning has beensingled out, such as: state of the development of the state administration system and the political situation; unity of the monetary and credit system of the state; stability and interaction of the distribution and redistributionprocessesof financial and credit resources at all levels of state administration; state of the development of credit infrastructure facilities; state economic policy in the field of financial and credit regulation.Themethodology for determining the effectiveness of the credit mechanism in the conditions of transformational processes has beenproposed
Formation of the Information Service in the Criminal Investigation Bodies in Siberia in the 1920s
Authors: Isaev V. I. , Mikheev D. Y.
Published: April 2023

The article examines the formation of the information service of the criminal investigation authorities in Siberia in the 1920s. The article analyzes the activities of the criminal investigation department to obtain operational information from the criminal environment in conditions of a sharp increase in crime. The authors come to the conclusion that the organization of operational investigative work was difficult, with an acute shortage of funding. The article emphasizes that the work of the information service of the criminal investigation authorities was well staged in the cities. Insufficient operational and agent capabilities in rural Siberia have led to the low effectiveness of the fight against crime in rural areas. In general, the activities of informants of the criminal investigation department increased the effectiveness of the fight against crime. During the period under study, the criminal investigation information service became an important part of the law enforcement system of the Soviet state.
Laser ablation of a sphenoid wing meningioma: A case report and review of the literature
Authors: Haskell-Mendoza Aden P. , Srinivasan Ethan S. , Suarez Alexander D. , Fecci Peter E.
Published: April 2023

Background:

Meningiomas are the most common primary central nervous system neoplasm in the United States. While the majority of meningiomas are benign, the World Health Organization (WHO) Grade I tumors, a not-insignificant proportion of tumors are in anatomically complex locations or demonstrate more aggressive phenotypes, presenting a challenge for local disease control with surgery and radiation. Laser interstitial thermal therapy (LITT) consists of stereotactic delivery of laser light for tumor ablation and is minimally invasive, requiring implantation of a laser fiber through a cranial burr hole. Herein, we demonstrate the first use of this technology in a progressive atypical sphenoid wing meningioma for a previously resected and irradiated tumor.

Case Description:

A 47-year-old female was diagnosed with a left-sided atypical meningioma, the WHO 2, of the sphenoid wing following acute worsening of bitemporal headache and dizziness. Given neurovascular involvement, a subtotal resection was performed, followed by stereotactic radiosurgery. Following progression 9 months from resection, the patient elected to proceed with LITT. The patient’s postoperative course was uncomplicated and she remains progression free at 24 months following LITT.

Conclusion:

We present the first use of LITT for a sphenoid wing meningioma documented in the literature, which demonstrated enhanced disease control for a lesion that was refractory to both surgery and radiation. LITT could represent an additional option for local control of progressive meningiomas, even in locations that are challenging to access surgically. More evidence is needed regarding the technical nuances of LITT for lesions of the skull base.
An Overview about the Relationship between Cystatin C and Inflammatory Diseases
Authors:   College of Biological Science and Technology, Agricultural University Of Hunan, 410128, China, Huang Yixin
Published: April 2023

Cystatin C (Cys-C) is a protease inhibitor that can be produced by nuclear cells in the human body. Its principal function is to inhibit the activity of various cysteine proteases in vivo. In addition, Cys-C also plays an essential role in regulating antigen presentation, extracellular matrix degradation, and the balance of protein production and decomposition in living cells. Cys-C is involved in the pathophysiological processes of chronic inflammatory diseases, including cardiovascular, cerebrovascular, and respiratory diseases. This article reviews the effects of Cys-C on chronic inflammatory diseases and its therapeutic prospects.
Hyperbaric Bupivacaine for Spinal Anaesthesia in Adults Patients: Comparison of Isobaric Bupivacaine 0.5% in 80mg/Ml and 40 Mg/Ml Glucose Solutions
Authors:   Clinical Instructor of Anesthesiology, Mount Lebanon Hospital-Balamand University Medical Center, Beirut- Lebanon, PW Nehme , JM Maalouli ,   Clinical Instructor of Anesthesiology, Mount Lebanon Hospital-Balamand University Medical Center, Lebanon, MT Merheb ,   Assistant medical director for clinical affairs at Mount, lebanon hospital-Balamand University Medical Center, EM Gharios ,   Medical Director, Mount lebanon hospital-Balamand University Medical Center, Lebanon
Published: April 2023

Background: The Baricity of bupivacaine is one of the most important factors to influence the characteristics of distribution of the local anaesthetic and spread of the blockade. Bupivacaine is rendered hyperbaric by adding glucose. The effect of differing degrees of hyperbaricity remains to be evaluated in term of spinal anesthesia blockade. Methods: Hundred patients who underwent lower abdominal, hips, and lower extremity surgeries were randomized into two groups in a double-blind, randomised, parallel group, prospective study. Group I received 0.5% isobaric bupivacaine with 80 mg/ml of glucose, while Group II received 0.5% isobaric bupivacaine with 40 mg/ml of glucose. Injection was made intrathecally in midline position at L3-4 and L4-L5 interspace in sitting position. The measured sensory blockade and motor blockade are the onset and duration. Duration of sensory block was the time measured from the time of the highest block for the regression to the S2 dermatome. Results: Success rate, spread and duration of sensory block were similar in both groups. The highest median level of sensory block was T3 (T2-T7) (median (10th/90th percentiles)) in both groups. Time to reach T10 did not differ between the groups. Power analysis suggested that a total number of 100 adults were required in both groups for a 90% chance at the 0.05 level of significance of detecting a10% difference in success between groups. Categorical data were tested using the chi square test. For continuous data the Mann–Whitney test was used. Results are presented as median (10–90th percentiles), number (%) of cases, the significance was set as P<0.05. Conclusion: These results demonstrate that bupivacaine in 80mg/ml glucose provides reliable spinal anaesthesia of shorter duration and with less hypotension than bupivacaine in 40 mg/ml glucose. The recovery profile for ropivacaine may be of interest given that more surgery is being performed in the day-case setting.
Transformation of enterprise management systems in the context of digitalization
Authors: Belova E. Yu. , Shevchenko M. O.
Published: April 2023

The article deals with the issues of qualitative transformation of enterprise management systems in the digital economy, the impact of the introduction of digital intelligence in the market space on the improvement of technologies for building business processes. The relevance of the problem under consideration is due to the huge competition in the existing business space, as well as the need to improve the efficiency of enterprises in the conditions of digitalization, adaptation of their business models to the new digital environment. The purpose of the study is to develop a methodology for the transformation of enterprise management systems that would improve the efficiency of all business processes in practice. The objectives of the study include the following: finding tools for determining the level of digital intelligence of Russian enterprises; establishing dependencies of profitability of enterprises on the level of digitalization of the latter; determining the nature and ways of transformation of management systems in the conditions of digitalization. Sociological and empirical research methods are widely used in the work. The main results of the study can be considered the introduction of an integral indicator of the level of digital intelligence of business systems; the formation of an enterprise business model in the context of digitalization; the derivation of the dependence of the integral indicator of the level of digital intelligence and profitability of enterprises; the establishment of a correlation between the growth of gross income of large enterprises in Russia and its GDP.
Research of the concept of polysensory branding and the possibilities of its adaptation to the web communication environment
Authors: Aleksandrova I. Yu.
Published: April 2023

The concept of polysensory branding and the problem of its adaptation to the web environment are investigated. The content specificity, genesis and psychological basis of the concept of polysensory branding are carried out. The article analyzed the «Smash your brand» technique, developed by Martin Lindstrom, in order to test the communicative effectiveness of the twelve components of the brand identity system, focused on different channels of perception. In order to scientifically substantiate the practical significance of the tools of polysensory branding and sensory marketing in an offline environment, the results of an empirical study conducted under the guidance of the author are considered. The empirical research is aimed at the identifying the impact features of the of the brand’s olfactory communication system on consumers. The study reveals the dependence of brand perception and consumer activity on the specifics of marginal suggestive aromatization of the store’s sales area. The problem of the limitations of sensory channels of brand communications in the web environment is studied, in particular, the impossibility of mechanical transfer of polysensory branding tools to the web environment due to technical limitations, as well as the peculiarities of the psychology of perception and behavior of online users. As a result of the conducted study, possible channels and tools for the implementation of brand polysensory web communications are identified and systematized, the author’s psychological model of the brand’s multi-channel communicative field is developed, which includes a mechanism for adapting offline channels of polysensory branding to the web communication environment.
Innovative development of regions and internal migration in Russia
Authors: Apenko S. N. , Lukash A. V.
Published: April 2023

The article considers internal migration and its connection with innovative transformations in the subjects of the Russian Federation from 2016 to 2021. The relevance of the topic is due to the need to overcome the negative trends associated with the constant outflow of the economically active population from some regions of the country. The purpose of the article is to establish the strength of statistical relationship between the interregional movement of labor resources and the key indicators that reveal the innovation potential of the subjects of the Russian Federation. The following tasks were solved: internal and interregional migration of able–bodied population was analyzed; federal districts with a positive and negative difference between incoming and outgoing able–bodied population were identified; the dynamics of interregional movement in the context of migration causes was examined, including the most common of them for the period from 2016 to 2021. The article uses general scientific methods of research, as well as statistical analysis of migration movement data within the country and indicators of the rating of innovative development of regions. The novelty of the work is related to the comparison of regional labor migration and aggregated assessments of economic, educational, digital and institutional development of the regions. As a result of the study it was found that to assess the strength of the statistical relationship between the migration activity of the population of the country’s regions and their position, respectively, in the ratings of aggregate innovative development with such indicators as the Russian regional Innovation Index (hereinafter referred to as the RRII); the index of socio–economic conditions of innovation activity (hereinafter referred to as the ISEC); the index of the quality of innovation policy (hereinafter referred to as the - IQIP), it can be both medium (for RRI) and weakly expressed (for ISEC and IQIP).
High throughput proteomics enabled by a fully automated dual-column liquid chromatography system coupled with mass spectrometry
Authors: Chen Liang , Zhang Ziwei , Gao Yu
Published: April 2023

This technical note presents a dual-column liquid chromatography system coupled with mass spectrometry (LC-MS), designed for high-throughput bottom-up proteomic analysis. Utilizing two 2-position 10-port valves, a binary nanoflow pump, and an integrated loading pump, the system enables the simultaneous operation of two parallel subsystems. Each subsystem comprises a trap column and an analytical column. A T-junction union is employed to divide the mobile phase from the loading pump into two parts, which permits one set of columns to undergo washing and equilibration while the subsequent sample is injected. Meanwhile, the previous sample elutes and undergoes analysis on the alternate set of columns, significantly increasing the analysis throughput. The approach demonstrates high reproducibility when analyzing HeLa tryptic digests, with average relative standard deviations (RSD) of 1.64% for protein identification across nine consecutive runs. This system exhibits comparable capacity for protein identification and proteome depth to that of traditional single-column systems. Owing to its straightforward equipment requirements and set up process, this method is highly accessible and easily adopted by other laboratories.
Point-of-care applicable metabotyping using biofluid-specific electrospun MetaSAMP®s directly amenable to ambient ionization mass spectrometry
Authors: De Spiegeleer Margot , Plekhova Vera , Geltmeyer Jozefien , Schoolaert Ella , Pomian Beata , Singh Varoon , Wijnant Kathleen , Dewindt Kimberly , Paukku Volter , De Loof Alexander , Gies Inge , Michels Nathalie , De Henauw Stefaan , De Graeve Marilyn , De Clerck Karen , Vanhaecke Lynn
Published: April 2023

While rapid analysis of the human biofluid metabolome is now possible using ambient ionization mass spectrometry (AIMS), these procedures are hampered by in-source matrix effects and reduced sample stability impeding metabolome coverage while remaining relatively labor-intensive. In this study, we aimed at developing biofluid-specific metabolome sampling membranes (MetaSAMP®s, WO2021/191467) that offer a directly applicable and stabilizing substrate for AIMS. Customized rectal, salivary and urinary MetaSAMP®s consisting of multilayered electrospun nanofibrous membranes of blended hydrophilic (polyvinylpyrrolidone and polyacrylonitrile) and lipophilic (polystyrene) polymers supported adequate metabolite ab- , ad-, and desorption. Moreover, MetaSAMP® demonstrated superior metabolome coverage and transport stability compared to crude biofluid analysis and was successfully validated in two pediatric cohorts (MetaBEAse, n=234, feces and urine; OPERA, n=138, saliva). By integrating anthropometric and (patho)physiological with MetaSAMP®-AIMS metabolome data, we obtained significant weight-driven predictions and clinical correlations. In conclusion, MetaSAMP® holds great clinical application potential for on-the-spot metabolic health stratification.
Combined Homogeneous and Heterogeneous Hydrogenation with Parahydrogen to Yield Catalyst-Free Solutions of Hyperpolarized [1-13C]Succinate
Authors: Eills James , Picazo-Frutos Román , Burueva Dudari , Kovtunova Larisa , Azagra Marc , Marco Rius Irene , Budker Dmitry , Koptyug Igor
Published: April 2023

We show that catalyst-free aqueous solutions of hyperpolarized [1-13C]succinate can be produced using parahydrogen-induced polarization (PHIP) and a combination of homogeneous and heterogeneous catalytic hydrogenation reactions. We generate hyperpolarized [1-13C]fumarate at 23% 13C polarization via PHIP with a homogeneous ruthenium catalyst, and subsequently remove the toxic catalyst and reaction side products via a purification procedure. Following this, we perform a second hydrogenation reaction to convert the fumarate into succinate using a solid Pd/Al2O3 catalyst. The catalyst is filtered off to yield a clean aqueous solution containing [1-13C]succinate at 11.9% 13C polarization for the hyperpolarized molecules. In this proof-of-principle demonstration we simplified the purification procedure by adding unpolarized fumarate to the mixtures so the observed succinate polarization was lower, but this step is not necessary for applications. This inexpensive polarization protocol has a turnover time of a few minutes, and represents a major advance for in vivo applications of [1-13C]succinate as a hyperpolarized contrast agent.
Substituting fossil-based with bio-based chemicals: The case of limonene as a greener pore expander for micellar templated silica
Authors: Sultan Umair , Städtke Katrin , Göpfert Andreas , Lemmen Daniel , Metwali Ezzeldin , Maiti Santanu , Schlumberger Carola , Yokosawa Tadahiro , Apeleo Zubiri Benjamin , Spiecker Erdmann , Vogel Nicolas , Unruh Tobias , Thommes Matthias , Inayat Alexandra
Published: April 2023

Porous materials are widely used in applications such as adsorption, catalysis and separation. The use of expander molecules is a versatile route to enlarge the mesopore size in micellar templated mesoporous silica materials. Typical expanders used for this purpose are fossil-based organic molecules such as trimethylbenzene (TMB). In the course of making such syntheses greener and more sustainable, it is highly desirable to substitute such fossil-based chemicals with renewable ones. Here, we show that bio-based limonene can be used as an alternative expander molecule for the synthesis of large-pore templated silica. On the basis of electron microscopy, nitrogen physisorption and small angle X-ray scattering we show that the substitution of TMB by limonene leads to very similar material characteristics, reaching mean mesopore diameters of 17-19 nm. A comparative life-cycle assessment demonstrates the reduced environmental impact of limonene production from citrus peel waste compared to TMB production, supporting the call for more applications of renewable chemicals, ideally from waste-streams, also for the production of porous materials.
Effects of herpes simplex virus on the mother and fetus during pregnancy: A review
Authors: Tumanyan Liliya A. , Isaeva Fidan M. , Aidamirova Khedi I. , Ibragimova Nuray Ya. , Zakharova Polina V.
Published: April 2023

The herpes virus is an urgent problem, particularly in the obstetrician-gynecologist practice. The main objective of this paper was to review and analyze current literature data on the effect of the herpes virus on the mother and child during gestation. A variation of the diagnosis of prenatal herpes infection was reviewed. The treatment and prevention methods of the herpes simplex virus for a pregnant woman are addressed. It was shown that preventive antihomotoxic therapy had a fetoprotective effect, significantly reducing the risk of prenatal infection. Introducing preconception preparation for a wide population cohort, including the suppression of viruses in the mother's body, is relevant. The following methodology was used during work on the article: selection of publications using modern information databases, analysis of the obtained information, systematization of materials, and presentation of conclusions. An electronic search was conducted using publications identified in the following databases: eLIBRARY.RU, Google Scholar, and PubMed.
LUMOS
Authors: k Dr.Shakila
Published: April 2023

The many facets of college life at Idhaya College of Arts and Science for Women are also depicted in LUMOS. We've had some of the most memorable experiences as a group through our participation in campus organizations. Through his magazine, we wish to share some of his vitality, excitement, and joy.
Nose bleeding on the background of antithrombotic therapy: features of the clinical picture and stopping of bleeding
Authors: Bychkova Nataliia
Published: April 2023

Introduction. At present, an increase in the number of patients with pathology of the cardiovascular system in need of antithrombotic therapy is stated. Features of the clinical picture of nosebleeds against the background of antithrombotic therapy are little studied and there are isolated reports on the effectiveness of various methods of stopping bleeding in this category of patients. Objective. Study of the features of the clinical picture and improvement of methods for stopping nosebleeds during antithrombotic therapy. Materials and methods. A study was made of the features of the clinical picture and the effectiveness of various methods of stopping bleeding in 156 patients with epistaxis, which developed against the background of antithrombotic therapy. All patients were divided into two groups: the main group (104 patients), in which nasal bleeding was stopped by a combined method, including the use of a two-chamber hydrotampon of our own design in combination with Nozochem gel and thermal exposure, and a control group (52 patients) where classical gauze tamponade of the nasal cavity was used. Results. Against the background of antithrombotic therapy, bleeding from the anterior parts of the nasal cavity was noted in 144 (92.3 %) patients. Bleeding from the posterior parts of the nasal cavity was diagnosed in 12 (7.7 %) patients. In the majority of patients (80.1 %), epistaxis had a diapedetic character of varying intensity. Against the background of antiplatelet therapy, epistaxis had a less intense character and a tendency to recurrence than in patients receiving anticoagulant therapy. Among anticoagulant therapy, a more intense and recurrent nature of epistaxis was noted in patients treated with warfarin. The method proposed by us showed its effectiveness in stopping nosebleeds in 100 (96.1 %) patients of the main group. In the control group of patients, gauze tamponade of the nasal cavity provided stable hemostasis in 44 (84.6 %) patients. Conclusions. Nosebleeds during antithrombotic therapy most often occur in the anterior parts of the nasal cavity and are predominantly diapedetic in nature. Against the background of antiplatelet therapy, nosebleeds are less intense and prone to recurrence than in patients undergoing anticoagulant therapy. The combined method proposed by us for stopping nosebleeds is more effective and safe in comparison with traditional gauze tamponade and can be recommended as a choice for stopping nosebleeds during antithrombotic therapy.