bluuebunny/crossref_metadata_2025 huggingface dataset:
Sigma Virus (DMelSV) Incidence in Lines of Drosophila melanogaster Selected for Survival following Infection with Bacillus cereus
Authors: Bentz Meghan L. , Humphrey Eve A. , Harshman Lawrence G. , Wayne Marta L.
Published: March 2017

The immune response of Drosophila melanogaster is complex and involves both specific and general responses to parasites. In this study we tested for cross-immunity for bacteria and viruses by scoring the incidence of infection with the vertically transmitted Sigma virus (DMelSV) in the progeny of a cross between females transmitting DMelSV at high frequencies and males from lines subjected to three selection regimes related to resistance to Bacillus cereus. There was no significant difference in transmission of DMelSV among selection regimes, though results suggest that the B. cereus selected lines had lower rates of infection by DMelSV. We found a significant difference in viral infection with respect to the sex of the progeny, with males consistently less likely to be infected than females. Given a finite energy budget, flies that have experienced immune system challenge may show alterations in other life history traits. Later eclosing progeny were also less likely to be infected than earlier eclosing progeny, indicating a relationship with development time. Finally, there was a significant interaction between the timing of collection and the sex of the progeny, such that later eclosing males were the most resistant group. Increased development time is sometimes associated with increased energy acquisition; from this perspective, increased development time may be associated with acquiring sufficient resources for effective resistance.
Dietary Saccharomyces cerevisiae Cell Wall Extract Supplementation Alleviates Oxidative Stress and Modulates Serum Amino Acids Profiles in Weaned Piglets
Authors: Liu Gang , Yu Lei , Martínez Yordan , Ren Wenkai , Ni Hengjia , Abdullah Al-Dhabi Naif , Duraipandiyan Veeramuthu , Yin Yulong
Published: March 2017

This research aims to evaluate the effects of dietary supplementation with Saccharomyces cerevisiae cell wall extract (SCCWE) on growth performance, oxidative stress, intestinal morphology, and serum amino acid concentration in weaned piglets. Utilizing a completely randomized design, 40 healthy piglets weaned at 21 d were grouped into 4 experimental treatments with 10 pigs per treatment group. Treatments consisted of a basal diet (T0), a basal diet with a 0.05% SCCWE (T1), a basal diet with a 0.10% SCCWE (T2), and a basal diet with a 0.15% SCCWE (T3). SCCWE supplementation increased the average daily gain and final body weight compared with T0 (P < 0.05). SCCWE in T2 and T3 improved the average daily feed intake and decreased the feed/gain ratio compared with T1 and T2 (P < 0.05). SCCWE decreased serum malondialdehyde (MDA) and increased activities of catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD) significantly compared to T0 (P < 0.05). SCCWE increased the concentration of Ile compared to T0 (P < 0.05). Moreover, the concentrations of Leu, Phe, and Arg were higher in T2 and T3 (P < 0.05). These findings indicate beneficial effects of SCCWE supplementation on growth performance, the concentration of some essential amino acids, and alleviation of oxidative stress in weaned piglets.
Overexpression ofCaAPXInduces Orchestrated Reactive Oxygen Scavenging and Enhances Cold and Heat Tolerances in Tobacco
Authors: Wang Jiangying , Wu Bin , Yin Hengfu , Fan Zhengqi , Li Xinlei , Ni Sui , He Libo , Li Jiyuan
Published: March 2017

Ascorbate peroxidase (APX) acts indispensably in synthesizing L-ascorbate (AsA) which is pivotal to plant stress tolerance by detoxifying reactive oxygen species (ROS). Enhanced activity of APX has been shown to be a key step for genetic engineering of improving plant tolerance. However it needs a deeper understanding on the maintenance of cellular ROS homeostasis in response to stress. In this study, we identified and characterized anAPX(CaAPX) gene fromCamellia azalea. Quantitative real-time PCR (qRT-PCR) analysis showed thatCaAPXwas expressed in all tissues and peaked in immature green fruits; the expression levels were significantly upregulated upon cold and hot stresses. Transgenic plants displayed marked enhancements of tolerance under both cold and heat treatments, and plant growth was correlated withCaAPXexpression levels. Furthermore, we monitored the activities of several ROS-scavenging enzymes includingCu/Zn-SOD,CAT,DHAR, andMDHAR, and we showed that stress tolerance was synchronized with elevated activities of ROS-scavenging. Moreover, gene expression analysis of ROS-scavenging enzymes revealed a role ofCaAPXto orchestrate ROS signaling in response to temperature stresses. Overall, this study presents a comprehensive characterization of cellular response related toCaAPXexpression and provides insights to breed crops with high temperature tolerances.
Laboratory Research on Fracture-Supported Shielding Temporary Plugging Drill-In Fluid for Fractured and Fracture-Pore Type Reservoirs
Authors: Liu Dawei , Kang Yili , Liu Quanwen , Lei Dengsheng , Zhang Bo
Published: March 2017

Based on fractures stress sensitivity, this paper experimentally studies fracture-supported shielding temporary plugging drill-in fluid (FSDIF) in order to protect fractured and fracture-pore type formation. Experimental results show the FSDIF was better than the CDIF for protecting fractured and fracture-pore type reservoir and the FSDIF temporary plugging rate was above 99%, temporary plugging ring strength was greater than 15 MPa, and return permeability was 91.35% and 120.83% before and after acidizing, respectively. The reasons for the better reservoir protection effect were analyzed. Theoretical and experiment studies conducted indicated that the FSDIF contained acid-soluble and non-acid-soluble temporary shielding agents; non-acid-soluble temporary shielding agents had high hardness and temporary plugging particles size was matched to the formation fracture width and pore throat size.
Complex Characteristics of Multichannel Household Appliance Supply Chain with the Price Competition
Authors: Ma Junhai , Lou Wandong
Published: March 2017

This paper studies the complex characteristics caused by the price competition in multichannel household appliance supply chains. We consider a two-level household appliance supply chain system consisting of a manufacturer with an Internet channel and a retailer with a traditional channel and an Internet channel. Each channel’s price-setting follows the bounded rational decision process in order to obtain the optimal profit or more market share. Considering that the price competition often leads to the demand and order fluctuation, we also investigate the bullwhip effect of the multichannel supply chains on the basis of the order-up-to-inventory policy. From the numerical simulation, we find a system in a chaotic state will suffer larger bullwhip effect than a stable system, and the manufacturer’s Internet channel is helpful to mitigate the bullwhip effect. Our results provide some useful managerial inspirations for the household manufacturer and retailers. Firstly, each channel should make their retail price with a suitable price adjustment speed in the stable region, and each time pricing cannot exceed the domain of attraction. Secondly, the manufacturer can adopt a more radical pricing strategy in their Internet channel to mitigate the bullwhip effect. Thirdly, the price adjustment should be reviewed and be appropriately reduced if the price adjustment is too large.
The Impact of Ce-Zr Addition on Nickel Dispersion and Catalytic Behavior for CO2 Methanation of Ni/AC Catalyst at Low Temperature
Authors: Le Minh Cam , Van Khu Le , Nguyen Thu Ha T. , Nguyen Ngoc Ha
Published: March 2017

The CO2 methanation was studied over 7 wt.% nickel supported on Ce0.2Zr0.8O2/AC to evaluate the correlation of the structural properties with catalytic performance. The catalysts were investigated in more detail by means of X-ray diffraction (XRD), transmission electron microscopy (TEM), and scanning electron microscopy (SEM). A sample of 7 wt.% nickel loading supported on activated carbon (AC) was also prepared for comparison. The results demonstrated that the ceria-zirconia solid solution phase could disperse and stabilize the nickel species more effectively and resulted in stronger interaction with nickel than the parent activated carbon phase. Therefore, 7% Ni/Ce0.2Zr0.8O2/AC catalyst exhibited higher activity for CO2 reduction than 7% Ni//AC. It can attain 85% CO2 conversion at 350°C and have a CH4 selectivity of 100% at a pressure as low as 1 atm. The high activity of prepared catalysts is attributed to the good interaction between Ni and Ce0.2Zr0.8O2 and the high CO2 adsorption capacity of the activated carbon as well.
1-(2-Chlorobenzyloxy)-3-[1,2,3]triazol-1-yl-propan-2-ol Derivatives: Synthesis, Characterization, and DFT-Based Descriptors Analysis
Authors: Román-Maldonado Eloisa , Reyes Horacio , Sanchez-Carmona Miguel A. , González-Rivas Nelly , Cuevas-Yañez Erick
Published: March 2017

A novel series of 1-(2-chlorobenzyloxy)-3-[1,2,3]triazol-1-yl-propan-2-ol derivatives was designed and synthesized using copper catalyzed alkyne-azide cycloaddition in the key step. Theoretical investigation of molecular and electronic properties by means of global and local reactivity indexes of the synthetized compounds was carried out, using DFT (Density Functional Theory) at PBEPBE/6-31++G⁎⁎level.
Driving Factor Analysis of Carbon Emissions in China’s Power Sector for Low‐Carbon Economy
Authors: Yan Dan , Lei Yalin , Li Li
Published: March 2017

The largest percentage of China’s total coal consumption is used for coal‐fired power generation, which has resulted in the power sector becoming China’s largest carbon emissions emitter. Most of the previous studies concerning the driving factors of carbon emissions changes lacked considerations of different socioeconomic factors. This study examines the impacts of eight factors from different aspects on carbon emissions within power sector from 1981 to 2013 by using the extended Stochastic Impacts by Regression on Population, Affluence and Technology (STIRPAT) model; in addition, the regression coefficients are effectively determined by a partial least squares regression (PLS) method. The empirical results show that (1) the degree of influence of various factors from strong to weak is urbanization level (UL) > technology level (T1) > population (P) > GDP per capita (A) > line loss (T2) > power generation structure (T3) > energy intensity (T4) > industry structure (IS); (2) economic activity is no longer the most important contributing factor; the strong correlation between electricity consumption and economic growth is weakening; and (3) the coal consumption rate of power generation had the most obvious inhibitory effect, indicating that technological progress is still a vital means of achieving emissions reductions.
Analysis of Differentially Expressed Genes in Gastrocnemius Muscle between DGAT1 Transgenic Mice and Wild-Type Mice
Authors: Ying Fei , Gu Hao , Xiong Yuanzhu , Zuo Bo
Published: March 2017

Adipose tissue was the major energy deposition site of the mammals and provided the energy for the body and released the external pressure to the internal organs. In animal production, fat deposition in muscle can affect the meat quality, especially the intramuscular fat (IMF) content. Diacylglycerol acyltransferase-1 (DGAT1) was the key enzyme to control the synthesis of the triacylglycerol in adipose tissue. In order to better understand the regulation mechanism of the DGAT1 in the intramuscular fat deposition, the global gene expression profiling was performed in gastrocnemius muscle between DGAT1 transgenic mice and wild-type mice by microarray. 281 differentially expressed transcripts were identified with at least 1.5-fold change and thepvalue < 0.05. 169 transcripts were upregulated and 112 transcripts were downregulated. Ten genes (SREBF1, DUSP1, PLAGL1, FKBP5, ZBTB16, PPP1R3C, CDC14A, GLUL, PDK4, and UCP3) were selected to validate the reliability of the chip’s results by the real-time PCR. The finding of RT-PCR was consistent with the gene chip. Seventeen signal pathways were analyzed using KEGG pathway database and the pathways concentrated mainly on the G-protein coupled receptor protein signaling pathway, signal transduction, oxidation-reduction reaction, olfactory receptor activity, protein binding, and zinc ion binding. This study implied a function role of DGAT1 in the synthesis of TAG, insulin resistance, and IMF deposition.
Mathematical and Computational Modeling in Complex Biological Systems
Authors: Ji Zhiwei , Yan Ke , Li Wenyang , Hu Haigen , Zhu Xiaoliang
Published: March 2017

The biological process and molecular functions involved in the cancer progression remain difficult to understand for biologists and clinical doctors. Recent developments in high-throughput technologies urge the systems biology to achieve more precise models for complex diseases. Computational and mathematical models are gradually being used to help us understand the omics data produced by high-throughput experimental techniques. The use of computational models in systems biology allows us to explore the pathogenesis of complex diseases, improve our understanding of the latent molecular mechanisms, and promote treatment strategy optimization and new drug discovery. Currently, it is urgent to bridge the gap between the developments of high-throughput technologies and systemic modeling of the biological process in cancer research. In this review, we firstly studied several typical mathematical modeling approaches of biological systems in different scales and deeply analyzed their characteristics, advantages, applications, and limitations. Next, three potential research directions in systems modeling were summarized. To conclude, this review provides an update of important solutions using computational modeling approaches in systems biology.
Changes in the MicroRNA Profile Observed in the Subcutaneous Adipose Tissue of Obese Patients after Laparoscopic Adjustable Gastric Banding
Authors: Nardelli Carmela , Iaffaldano Laura , Pilone Vincenzo , Labruna Giuseppe , Ferrigno Maddalena , Carlomagno Nicola , Dodaro Concetta Anna , Forestieri Pietro , Buono Pasqualina , Salvatore Francesco , Sacchetti Lucia
Published: March 2017

Background. Laparoscopic adjustable gastric banding (LAGB) results in significant lasting weight loss and improved metabolism in obese patients. To evaluate whether epigenetic factors could concur to these benefits, we investigated the subcutaneous adipose tissue (SAT) microRNA (miRNA) profile before (T0) and three years (T1) after LAGB in three morbidly obese women. Case Reports. SAT miRNA profiling, evaluated by TaqMan Array, showed four downexpressed (miR-519d, miR-299-5p, miR-212, and miR-671-3p) and two upexpressed (miR-370 and miR-487a) miRNAs at T1 versus T0. Bioinformatics predicted that these miRNAs regulate genes belonging to pathways associated with the cytoskeleton, inflammation, and metabolism. Western blot analysis showed that PPAR-alpha, which is the target gene of miR-519d, increased after LAGB, thereby suggesting an improvement in SAT lipid metabolism. Accordingly, the number and diameter of adipocytes were significantly higher and lower, respectively, at T1 versus T0. Bioinformatics predicted that the decreased levels of miR-212, miR-299-5p, and miR-671-3p at T1 concur in reducing SAT inflammation. Conclusion. We show that the miRNA profile changes after LAGB. This finding, although obtained in only three cases, suggests that this epigenetic mechanism, by regulating the expression of genes involved in inflammation and lipid metabolism, could concur to improve SAT functionality in postoperative obese patients.
Antioxidant and Ex Vivo Immune System Regulatory Properties of Boswellia serrata Extracts
Authors: Beghelli Daniela , Isani Gloria , Roncada Paola , Andreani Giulia , Bistoni Onelia , Bertocchi Martina , Lupidi Giulio , Alunno Alessia
Published: March 2017

Boswellia serrata (BS) is an important traditional medicinal plant that currently represents an interesting topic for pharmaceutical research since it possesses several pharmacological properties (e.g., anti‐inflammatory, antimicrobial, and antitumour). The safety and versatility of this dietary supplement should allow for its use in numerous pathological conditions; however the quality of the extracts needs to be standardized to increase the clinical success rate resulting from its use. In the present study, different commercially available B. serrata extracts were employed to compare their AKBA content and in vitro antioxidant power. Furthermore, their ability to modulate the immune system regulatory properties was investigated. Our results showed that the AKBA content varied from 3.83 ± 0.10 to 0.03 ± 0.004%, with one sample in which it was not detectable. The highest antioxidant power and phenolic content were shown by the same extract, which also exhibited the highest AKBA concentration. Finally, the BS extracts showed the ability to influence the regulatory and effector T‐cell compartments. Our results suggest that frankincense should be further investigated for its promising potentiality to modulate not only inflammation/oxidative stress but also immune dysregulation, but attention should be paid to the composition of the commercial extracts.
Fimasartan Ameliorates Nonalcoholic Fatty Liver Disease through PPARδ Regulation in Hyperlipidemic and Hypertensive Conditions
Authors: Lee Yong-Jik , Jang Yoo-Na , Han Yoon-Mi , Kim Hyun-Min , Jeong Jong-Min , Seo Hong Seog
Published: March 2017

To investigate the effects of fimasartan on nonalcoholic fatty liver disease in hyperlipidemic and hypertensive conditions, the levels of biomarkers related to fatty acid metabolism were determined in HepG2 and differentiated 3T3-L1 cells treated by high fatty acid and liver and visceral fat tissue samples of spontaneously hypertensive rats (SHRs) given high-fat diet. In HepG2 cells and liver tissues, fimasartan was shown to increase the protein levels of peroxisome proliferator-activated receptor delta (PPARδ), phosphorylated 5′ adenosine monophosphate-activated protein kinase (p-AMPK), phosphorylated acetyl-CoA carboxylase (p-ACC), malonyl-CoA decarboxylase (MCD), medium chain acyl-CoA dehydrogenase (MCAD), and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), and it led to a decrease in the protein levels of 11 beta-hydroxysteroid dehydrogenase 1 (11β-HSDH1), fatty acid synthase (FAS), and tumor necrosis factor-alpha (TNF-α). Fimasartan decreased lipid contents in HepG2 and differentiated 3T3-L1 cells and liver tissues. In addition, fimasartan increased the adiponectin level in visceral fat tissues. The antiadipogenic effects of fimasartan were offset by PPARδ antagonist (GSK0660). Consequently, fimasartan ameliorates nonalcoholic fatty liver disease mainly through the activation of oxidative metabolism represented by PPARδ-AMPK-PGC-1α pathway.
Bilateral Sertoli Cell Tumors in a Patient with Androgen Insensitivity Syndrome
Authors: de Souza Roberta Fonseca , Pereira da Silva Janaina , Vieira Balla Bruno , Neves Ferreira Rodrigo , Chambô Filho Antônio
Published: March 2017

Androgen insensitivity syndrome is the most common cause of male pseudohermaphroditism and the third most common cause of primary amenorrhea. This genetic alteration is a consequence of inherited defects on the X chromosome causing total or partial damage to the intrauterine virilization process due to functional abnormalities in the androgen receptors. The present report describes a 22-year-old patient with a female phenotype and a 46, XY karyotype, presenting with bilateral inguinal tumors. The tumors were surgically removed at the Santa Casa de Misericórdia Hospital in Vitória, Espírito Santo, Brazil. Pathology revealed bilateral testicles with Sertoli cell tumors. According to the international literature, prophylactic gonadectomy following puberty is recommended due to the progressive risk of neoplastic transformation in the residual gonads.
Esterification of Microwave Pyrolytic Oil from Palm Oil Kernel Shell
Authors: Abdul Aziz Sharifah Mona , Wahi Rafeah , Ngaini Zainab , Hamdan Sinin , Yahaya Syamila Aimi
Published: March 2017

Microwave pyrolysis is a potential for producing alternative fuel from biomass, such as palm kernel shell (PKS). However, the resulting microwave pyrolytic oil (bio-oil) was highly acidic and has low calorific value and therefore must undergo additional process to improve the physicochemical properties. In this study, attempt was made to improve the pH and calorific value of bio-oil produced from PKS via esterification process. The effect of esterification with ethanol in the presence of sulphuric acid as a catalyst on selected biodiesel qualities was also investigated. The esterification process has successfully improved the pH value from 3.37 to 5.09–5.12 and the calorific value was increased from 27.19 to 34.78–41.52 MJ/kg. Conclusively, the EO has comparatively better properties in terms of its smell, pH, calorific value, and absence of environmentally undesirable compounds. However, future works should include ASTM 6751 specifications tests for biodiesel to evaluate the bio-oil’s suitability for commercial use.
Elastomeric Nanocomposite Based on Exfoliated Graphene Oxide and Its Characteristics without Vulcanization
Authors: Habib Nasser Abdullah , Chieng Buong Woei , Mazlan Norkhairunnisa , Rashid Umer , Yunus Robiah , Rashid Suraya Abdul
Published: March 2017

Rubber nanocomposites have emerged as one of the advanced materials in recent years. The aim of this work was to homogeneously disperse graphene oxide (GO) sheets into Nitrile Butadiene Rubber (NBR) and investigate the characteristics of GO/NBR nanocomposite without vulcanization. A suitable solvent was found to dissolve dry NBR while GO was exfoliated completely in an aqueous base solution using sonication. GO was dispersed into NBR at different loadings by solution mixing to produce unvulcanized GO/NBR nanocomposites. Scanning Electron Microscopy (SEM), Fourier-Transform Infrared Spectroscopy (FTIR), and X-Ray Diffraction (XRD) were used to characterize the samples. Furthermore, mechanical and electrical properties of unvulcanized GO/NBR nanocomposites were carried out to determine the influence of GO on the NBR properties. The results showed that the modulus of GO/NBR nanocomposite at 1 wt% of GO was enhanced by about 238% compared with unfilled NBR. These results provide insight into the properties of unvulcanized GO/NBR nanocomposite for application as coatings or adhesives.
Data Analysis and Modeling of Chilled Water Loops in Air Conditioning Systems
Authors: Zhao Zhida , Yu Nanyang , Yu Tao , Zhang Haofei
Published: March 2017

Artificial neural network has been widely used in air conditioning systems as an effective method for predicting parameters, and the accuracy of ANN model relies on training data and network structure. In order to increase the quality of chilled water loops model, this paper develops an optimal data processing algorithm combining Kalman filtering with particle swarm optimization to compensate for uncertain factors and disturbances of collected data from the case building and establishes the nonlinear variation trend database. Based on Elman and BP neural networks, this paper proposes the improved network structures to avoid the local optimum predicted value of chilled water loops and increase data training speed. Simulation results show that this algorithm improves the data accuracy of current percentage (CP) of chillers and chilled water temperatures 12% and 9%. Compared with Elman and BP models, mean absolute errors of CP improved models are improved 24.1% and 10.3%, and mean squared errors of water temperature improved models are improved 5.2% and 4.8%. For the purpose of energy conservation control in air conditioning systems, this work has an application value and can be used for predicting other parameters of buildings.
Expression Pattern of Smad4/GATA3 as a Predictor of Survival in Invasive Ductal Carcinoma of the Breast
Authors: Min Kyueng-Whan , Kim Dong-Hoon , Do Sung-Im , Chae Seoung Wan , Kim Kyungeun , Sohn Jin Hee , Lee Hyun Joo , Do In-Gu , Pyo Jung-Soo , Kim Yuil , Kim Dong Hyun , Yang Jung-Ho , Lee Sang-Jo , Oh Young Ha , Oh Sukjoong , Choi Seon Hyeong , Park Yong Lai , Park Chan Heun , Kim Eun-Kyung , Kwon Mi Jung , Seo Jinwon
Published: March 2017

Background: Smad4 and GATA3 proteins are known prognostic markers in various cancers. Smad4 is a mediator linked to both tumour suppression and progression. GATA3 is a regulator of development and morphogenesis of the mammary gland. We assessed and compared the predictive performance of Smad4 and GATA3 for clinical outcomes in patients with breast cancer. Methods: The combined expression pattern based on Smad4+/- and GATA3+/- was evaluated by immunostaining using breast cancer tissue microarray, and the relationships between protein expression and clinicopathological variables were analysed. Results: Smad4 expression was only associated with an ill-defined tumour border, whereas GATA3 was associated with several good prognostic factors. On analysis of combined markers, there was a significant difference in the expression of fascin (an important factor for cancer invasiveness) between the Smad4+/GATA3- and Smad4-/GATA3+ groups. Smad4+/GATA3- was correlated with worse clinicopathological parameters, relapse-free survival (RFS), and overall survival (OS), compared to Smad4-/GATA3+. Conclusion: Combined markers of Smad4/GATA3 showed a superior performance compared to single markers for predicting RFS and OS in patients with breast cancer.
Cholangiocellular Carcinoma
Authors: Vogel Arndt , Saborowski Anna
Published: March 2017

Background: Cholangiocarcinomas (CCAs) are aggressive malignancies that display features of biliary differentiation. According to their anatomical location, CCAs are commonly classified as intrahepatic and extrahepatic tumors, the latter entity being further subdivided into perihilar CCAs, also termed as Klatskin tumors, and distal tumors. While a majority of CCAs occur sporadically, established risk factors such as liver fluke infestation or primary sclerosing cholangitis exist. Summary: Due to lack of efficient early screening markers, CCAs are frequently diagnosed at an advanced stage when curative surgical resection is not an option. Chemotherapy with gemcitabine and cisplatin is currently the standard palliative treatment that prolongs overall survival by 3.6 months as compared to monotherapy with gemcitabine. For CCA patients who progress under gemcitabine/cisplatin, the paucity of prospective, randomized trials is detrimental, and there is currently no recommended second-line regimen with respect to chemotherapy or loco-regional treatment modalities. Molecular profiling of CCAs supports the implementation of targeted approaches, and it is reasonable that personalized therapy will become a mainstay of CCA treatment. In addition, the advent of immunotherapy holds considerable promise, yet, similar to targeted treatment, needs to be prospectively evaluated in clinically and genetically thoroughly characterized patients. Key Points: (1) CCA is a genetically diverse and highly aggressive malignancy. (2) Gemcitabine in combination with cisplatin or oxaliplatin is the current first-line chemotherapy in non-resectable patients. (3) Loco-regional treatment modalities exist but need to be evaluated in prospective randomized trials in the context of systemic chemotherapy. (4) Targeted therapies in molecularly defined subgroups of patients and immunotherapies alone or in combinations will most likely improve survival in the future.
Fetal Magnetic Resonance Imaging Findings in Prenatal Zika Virus Infection
Authors: Sanín-Blair José Enrique , Gutiérrez-Márquez Carolina , Herrera Diego A. , Vossough Arastoo
Published: March 2017

Brain lesions and malformations have been described on ultrasonography of prenatal Zika infection; however, there are scarce reports about fetal magnetic resonance (MR) findings. We report 3 cases of fetuses with confirmed intrauterine Zika virus infection evaluated by ultrasound and fetal MR. Various morphometric measurements were assessed and brain maturation was calculated with the fetal total maturation score. Fetuses with prenatal Zika virus infection showed retardation in brain maturation indexes evaluated by fetal MR. Brain calcifications were demonstrated by neurosonography in all cases, while fetal MR characterized the specific type of cortical development malformation.
Gastric Acid Suppression Is Associated with an Increased Risk of Adverse Outcomes in Inflammatory Bowel Disease
Authors: Shah Rajesh , Richardson Peter , Yu Hong , Kramer Jennifer , Hou Jason Ken
Published: March 2017

Background: The intestinal microbiota may influence inflammatory bowel disease (IBD) activity. Histamine 2 receptor antagonists (H2RAs) and proton pump inhibitors (PPIs) can alter the intestinal microbiota. The aim of this study was to assess the relationship between H2RAs, PPIs, and IBD-related outcomes. Methods: We conducted a case-control study of IBD patients using the Veterans Health Affairs databases. Cases were defined by their first instance of an IBD-related hospitalization or surgery and the exposure of interest was H2RA or PPI use 30 days prior to the outcome. Incidence density ratios were calculated using conditional logistic regression. Results: In a cohort of 58,459 patients with IBD, we found 4,887 cases and 9,761 controls with ulcerative colitis (UC) and 4,876 cases and 9,745 controls with Crohn disease (CD). Filled prescriptions for H2RAs were associated with an increased risk of IBD-related hospitalization or surgery in CD patients (adjusted incidence density ratio 1.18; 95% CI 1.03-1.34). A similar association was found for PPIs in UC patients (adjusted incidence density ratio 1.11; 95% CI 1.02-1.21) and CD patients (adjusted incidence density ratio 1.12; 95% CI 1.02-1.22). Conclusions: H2RAs and PPIs were associated with a modestly increased risk of IBD-related hospitalization or surgery.
Validation of the Nuclear Cataract Grading System BCN 10
Authors: Barraquer Rafael I. , Pinilla Cortés Laura , Allende Miriam J. , Montenegro Gustavo A. , Ivankovic Bozidar , D'Antin Justin Christopher , Martínez Osorio Hernán , Michael Ralph
Published: March 2017

Purpose: To evaluate a new nuclear cataract grading system which is intended as a surgical guidance system to predict lens hardness before cataract surgery. Methods: The new BCN 10 grading system consists of frontal and cross-sectional slit-lamp images of human eye lenses, ranging from a completely transparent lens nucleus to a totally black nuclear cataract. Validation was done with 9 observers for 110 cases. Two modalities were applied, and observers were asked to use only whole digits and then half digits for grading. Results: Repeatability with regard to test-retest differences showed a mean limit of agreement of 1.70 for whole digits and 1.32 for half digits. The absolute test-retest difference was close to zero for low as well high degrees of cataracts. Reliability for the entire group of 9 observers yielded an intraclass correlation coefficient which was within the same confidence interval, i.e., 0.991-0.995, for whole digits and half digits. Conclusions: BCN 10 grading repeatability was not affected by the severity of the cataract. It showed very good repeatability. Repeatability was significantly higher when the observers used half digits compared to whole digits. Reliability was found to be very good as well, independently of the use of whole or half digits.
Early-Stage Gastric Cancer Can Be Found in Improved Atrophic Mucosa over Time from Successful Helicobacter pylori Eradication
Authors: Majima Atsushi , Handa Osamu , Naito Yuji , Dohi Osamu , Okayama Tetsuya , Yoshida Naohisa , Kamada Kazuhiro , Katada Kazuhiro , Uchiyama Kazuhiko , Ishikawa Takeshi , Takagi Tomohisa , Konishi Hideyuki , Yagi Nobuaki , Itoh Yoshito
Published: March 2017

Background/Aims: Early-stage gastric cancer (EGC) is detected even after successful Helicobacter pylori eradication. This study is aimed at clarifying the clinicopathological characteristics of EGC detected after successful H. pylori eradication. Methods: This retrospective study analyzed 57 cases of EGC detected after successful H. pylori eradication and resected endoscopically at Kyoto Prefectural University of Medicine, between January 2009 and June 2014. Clinicopathological findings of 57 cases (H. pylori-eradicated group) were investigated, and compared with those in active H. pylori infection resected in the same period (H. pylori-positive group). Results: Most EGCs were detected in patients with severe atrophic mucosa, both in H. pylori-eradicated and H. pylori-positive groups, while the percentage of EGC detected in patients with mild atrophic mucosa gradually increased over time from successful eradication (H. pylori-positive: 7%, up to the fourth year since eradication: 11%, after the fifth year since eradication: 32%). The percentage of EGC detected in patients with mild atrophic mucosa after the fifth year since eradication was significantly higher than that in patients with active H. pylori infection (p = 0.004). Conclusion: After the fifth year following eradication, we should be alert to the incidence of EGC, irrespective of the severity of mucosal atrophic change.
Quantitative Assessment of Trunk Muscles Involvement in Patients with Myotonic Dystrophy Type 1 Using a Whole Body Muscle Magnetic Resonance Imaging
Authors: Park Donghwi , Park Jin-Sung
Published: March 2017

Objective: The aim of this study was to analyze the pattern of trunk muscles involvement through a muscle MRI, in relation to the clinical data of patients diagnosed with myotonic dystrophy type 1 (DM1). Materials and Methods: Patients with DM1 who visited the neurology department were enrolled (n = 19). In all patients, the fatty degeneration of the muscle MRI in the lower cervical, upper thoracic, middle thoracic, and lumbosacral spine extensor muscle group and trunk flexor muscle group was evaluated. Clinical data, including CTG repeats, spinal deformity were analyzed to find the correlations with the fatty degeneration of trunk muscles in the muscle MRI. Results: All DM1 patients who presented with very mild to severe functional status showed T1-weghted high intensity signals in the upper-thoracic spine extensor muscle group. The sum MRI score of the spine extensor muscle group showed a significant correlation with the 6-min walking test, and Cobb's angle. Conclusions: DM1 frequently affects the trunk muscles, even in the early stage of disease progression, regardless of disease severity or age of onset. Among the para-vertebral muscles, the selective involvement of spine extensor muscles may explain the cause of spinal deformities, which mirrors the functional status of DM1.
Thawing of Pooled, Solvent/Detergent-Treated Plasma octaplasLG®: Validation Studies Using Different Thawing Devices
Authors: Heger Andrea , Pock Katharina , Römisch Jürgen
Published: March 2017

Background: The aim of this study was to perform validation of the thawing process for solvent/detergent-treated plasma octaplasLG® using different thawing devices. Optimized settings for temperature and thawing time should be defined based on the results of both temperature measurements and extensive biochemical characterization studies. Methods: octaplasLG units were thawed using water bath systems (i.e. MB-13A, QuickThaw® DH4), dry tempering systems (i.e. plasmatherm, SAHARA-III), and microwave oven (i.e. transfusio-therm® 2000). Optimized thawing conditions were defined. Subsequently, using the selected thawing conditions, octaplasLG units were thawed and tested on product release parameters. Results: The fastest thawing was observed for the microwave oven. All octaplasLG units thawed by different devices and optimized thawing conditions were clear and free of solid and gelatinous particles, indicating no protein denaturation or overheating. In addition, no significant differences were found in the coagulation and inhibition activity and hemostatic potency of octaplasLG when thawed by the different devices tested. All parameters after thawing were within the product release specification levels. Conclusion: Our study demonstrated that octaplasLG can be thawed using all above listed devices without any negative influence on the plasma quality, presupposed that optimized settings defined for this plasma product are used.
Clinical Pattern of Recurrent Disease during the Follow-Up of Rectal Carcinoma
Authors: Wieldraaijer Thijs , Bruin Pascal , Duineveld Laura A.M. , Tanis Pieter J. , Smits Anke B. , van Weert Henk C.P.M. , Wind Jan
Published: March 2017

Background/Aims: Several initiatives have started to transfer colorectal cancer follow-up (FU) from secondary to primary care. For this purpose, it is important to assess when and how recurrences of rectal carcinoma are detected after treatment with curative intent. Methods: Retrospective multicentre cohort study. Patients participating in an FU programme after curative intended treatment for rectal cancer stages I-III between 2007 and 2014. Results: Of the 378 patients, 64 (17%) developed recurrent disease (RD). Most were detected during scheduled FU consultations (n = 55) by (a combination of) radiological examinations and carcinoembryonic antigen levels, and were asymptomatic (n = 53); outside scheduled FU consultations, RD was detected during the treatment of postoperative complications or ostomy reversal (n = 5), or due to symptoms (n = 4). Most frequent sites of recurrence were liver (50%), lung (44%), multiple (22%) or locoregional (16%). Treatment of RD with curative intent was performed more frequently when detected during scheduled FU (60 vs. 22%). The only predictive factor for developing RD was stage III disease on initial presentation. Conclusions: The majority of rectal cancer patients are diagnosed with RD at an asymptomatic stage during scheduled FU consultations. Only a few patients presented with RD outside the FU programme. Arguably, general practitioners could order these same diagnostic tests during FU.
Speech Recognition Using Combined Fuzzy and Ant Colony algorithm
Authors: Jalili Fooad , Jafari Barani Milad
Published: March 2017

In recent years various methods has been proposed for speech recognition and removing noise from the speech signal became an important issue. In this paper a fuzzy system has been proposed for speech recognition that can obtain accurate results using classification of speech signals with “Ant Colony” algorithm.  First, speech samples are given to the fuzzy system to obtain a pattern for every set of signals that can be helpful for dimensionality reduction, easier checking of outcome and better recognition of signals.  Then, the “ACO” algorithm is used to cluster these signals and determine a cluster for each input signal. Also, with this method we will be able to recognize noise and consider it in a separate cluster and remove it from the input signal. Results show that the accuracy for speech detection and noise removal is desirable.
Synthesis of an Optimal Dynamic Regulator Based on Linear Quadratic Gaussian (LQG) for the Control of the Relative Humidity under Experimental Greenhouse
Authors: Outanoute M. , Lachhab A. , Ed-dahhak A. , Guerbaoui M. , Selmani A. , Bouchikhi B.
Published: March 2017

This paper describes one practical approach that suggests a model based technique to control in real time the relative humidity under greenhouse. The humidity level is one of the most difficult environmental factors to be regulated in greenhouse. Moreover, maintaining and correcting for more or less humidity can be a challenge for even the most sophisticated monitoring and control equipment. For these raisons, a Linear Quadratic Gaussian (LQG) controller for relative humidity regulation under greenhouse turns out to be useful. Indeed a LQG controller is proposed for a relative humidity under a greenhouse control task. So, the state space model, which is best fitting the acquired data, was identified using the Numerical Subspace State Space System IDentification (N4SID) algorithm. The mathematical model that is obtained will be used for evaluating the parameters of LQG strategy. The proposed controller is implemented in two steps, in one hand, Kalman filter (KF) is used to develop an observer that estimates the state of relative humidity under greenhouse. In the other hand, the state feedback controller gain is estimated using a linear quadratic criterion function. The suggested optimal implemented controller using Matlab/Simulink environment is applied to an experimental greenhouse. We found, according to the results, that the controller is able to lead the inside relative humidity to the desired value with high accuracy, regardless of the external disturbances.
Optimal Placement of TCSC Based on Sensitivity Analysis for Congestion Management
Authors: Kumari.CH Naga Raja , Sekhar K. Chendra
Published: March 2017

In a deregulated electricity market whenever congestion management problem occurs, the network collapse because of voltage instability. In this paper total real and reactive power loss deviation based sensitivity indexes (PLDS and QLDS) with rank co-relation concept, has been proposed for the optimal location and operating range of TCSC device. With this placement  the power flow in over loaded overhead lines has been reduced and that results in an increased loadability of the power system and also improves the voltage stability and security and also solves the congestion management problem. So ultimately, a more energy efficient transmission system is possible. The case studies were conducted on IEEE 14 bus test system. The ensue corroborate the intended approach for social welfare maximization inreal time.
Single Perceptron Model for Smart Beam forming in Array Antennas
Authors: Senthilkumar K.S. , Pirapaharan K. , Hoole P.R.P , Hoole R.R.H
Published: March 2017

In this paper, a single neuron neural network beamformer is proposed. A perceptron model is designed to optimize the complex weights of a dipole array antenna to steer the beam to desired directions. The objective is to reduce the complexity by using a single neuron neural network and utilize it for adaptive beamforming in array antennas. The selection of nonlinear activation function plays the pivotal role in optimization depends on whether the weights are real or complex. We have appropriately proposed two types of activation functions for respective real and complex weight values.   The optimized radiation patterns obtained from the single neuron neural network are compared with the respective optimized radiation patterns from the traditional Least Mean Square (LMS) method. Matlab is used to optimize the weights in neural network and LMS method as well as display the radiation patterns.
Feasibility and Efficacy of BLE Beacon IoT Devices in Inventory Management at the Shop Floor
Authors: Ramakrishnan Ravi , Gaur Loveleen , Singh Gurinder
Published: March 2017

Inventory Management is a key area for customer service and cost optimization in any manufacturing setup. As companies turn global and have thousands of components and hundreds of warehouses the inventory becomes a nightmare and a lot of time is spend in tracking inventory and ensuring right shipments. Traditional systems of robotic arms for inventory pick and drop have been based on premises of marking areas of the warehouse and tracking it. However with the advent of IoT all this is set to change as inventory objects become more self-aware and self-broadcasting. This paper technically suggests an approach of managing inventory using low energy blue tooth beacons and also does a statistical case research on two groups of the same organization one before the pilot run where traditional barcode scanners are used to track inventory and other one where the pilot trial BLE beacon technology was used. Statistically the IoT-beacon users are much more efficient and accurate and save lot of time and costs in the short run itself.
A Secured Cloud Data Storage with Access Privileges
Authors: Vurukonda Naresh , Rao B. Thirumala , Reddy B. Tirapathi
Published: March 2017

In proposed framework client source information reinforcements off-site to outsider distributed storage benefits to decrease information administration costs. In any case, client must get protection ensure for the outsourced information, which is currently safeguarded by outsiders. To accomplish such security objectives, FADE is based upon an arrangement of cryptographic key operations that are self-kept up by a majority of key supervisors that are free of outsider mists. In unmistakable, FADE goes about as an overlay framework that works flawlessly on today's distributed storage administrations. Actualize a proof-of-idea model of FADE on Amazon S3, one of today's distributed storage administrations. My work oversee, esteem included security highlights acclimatize were today's distributed storage administration. our research work proceeds in ensuring the file access control and assured deletion in multi cloud environment and reducing the meta data management, there by the cloud storage become more attractive and many users will adopt the cloud space in order to diminish the data storage cost.
A Non-Linear Controller for Forecasting the Rising Demand for Electric Vehicles Applicable to Indian Road Conditions
Authors: S Poorani , R Murugan
Published: March 2017

These days load forecasting is much more required  in order to reduce the wastage of energy. This paper is to implement & develop the idea of short term load forecasting by using Artificial Neural Network, the design of the neural network model, input data selection and Training & Testing by using short term load forecasting will be described in paper. For the EV load forecasting only 2 variables are being used as temperature and humidity to forecast the output as load. This type of designed ANN model will be mapped by using historical data of temperature and humidity (taken from meteorological sites), whereas it is being Trained & Tested by using historical data of loading of EV charging stations (Chetan maini ,Bangalore) of a particular area as Coimbatore to give the desired result. Training & Testing done by using large amount of historical data of weather conditions and loading data (kV). By the help of this model they can predict their daily loads (next day's load) by putting historical data in the acquired algorithm.
Empirical Mode Decomposition (EMD) Based Denoising Method for Heart Sound Signal and Its Performance Analysis
Authors: Salman Amy Hamidah , Ahmadi Nur , Mengko Richard , Langi Armein Z. R. , Mengko Tati L. R.
Published: March 2017

In this paper, a denoising method for heart sound signal based on empirical mode decomposition (EMD) is proposed. To evaluate the performance of the proposed method, extensive simulations are performed using synthetic normal and abnormal heart sound data corrupted with white, colored, exponential and alpha-stable noise under different SNR input values. The performance is evaluated in terms of signal-to-noise ratio (SNR), root mean square error (RMSE), and percent root mean square difference (PRD), and compared with wavelet transform (WT) and total variation (TV) denoising methods. The simulation results show that the proposed method outperforms two other methods in removing three types of noises.