bluuebunny/crossref_metadata_2025 huggingface dataset:
Oxidation of glycerol-3-phosphate in porcine and bovineadrenal cortex mitochondria.
Authors: Popinigis Jerzy , Antosiewicz Jedrzej , Kaczor Jan Jacek , Rauchová Hana , Lenaz Giorgio
Published: December 2024

The capabilities of porcine adrenal cortex mitochondria to oxidize glycerol-3-phosphate (GP) were studied. In comparison with bovine adrenal cortex mitochondria, porcine mitochondria oxidized GP about three times more actively (18.9 vs 6.1 nmol O(2)/min per mg protein in the presence of ADP) and the activity of mitochondrial glycerol-3-phosphate dehydrogenase was about four times higher (33.4 vs 8.2 nmol/min per mg protein). In porcine adrenal cortex mitochondria we found similar values for succinate and GP oxidation both in the absence and presence of ADP or deoxycorticosterone (DOC). Rotenone sensitivity of DOC stimulation of GP oxidation indicated that porcine adrenal cortex mitochondria are able to oxidize GP and thus to generate NADPH from GP, presumably via reverse electron transport followed by energy-dependent NADH-NADP transhydrogenation.
Ovocystatin affects actin cytoskeleton organization and induces proapoptotic activity.
Authors: Malicka-Blaszkiewicz Maria , Filipczak Nina , Gołąb Krzysztof , Juszczyńska Katarzyna , Sebzda Tadeusz , Gburek Jakub
Published: December 2024

Ovocystatin is a chicken egg white protein, generally known for its inhibitory activity against cysteine proteases. However, biological activity of ovocystatin does not seem to be well recognized in respect to other possible cellular effects. Our attention has been focused on ovocystatin cytotoxic effects in relation to its influence on actin cytoskeleton organization and apoptosis induction. In vitro studies with human melanoma A375, human cervix HeLa cancer cells and normal human fibroblasts - NHDF were done. Cytotoxic activity of ovocystatin was seen in respect to apoptosis induction - manifested by cell shape changes, phosphatydylserine translocation and actin cytoskeleton reorganization. Normal human fibroblasts have shown lower sensitivity to ovocystatin as compared with human melanoma A375 and human cervix HeLa cancer cells. In conclusion, ovocystatin affects actin cytoskeleton organization and displays proapoptotic activity towards applied cell lines. This implicates its application as a potential anticancer drug. However, its adverse effects on normal cells should be taken into consideration.
Overexpression of the zinc finger protein gene OsZFP350 improves root development by increasing resistance to abiotic stress in rice
Authors: Kang Zhenhui , Qin Tong , Zhao Zhiping
Published: December 2024

The root system of rice is influenced by various environmental factors. However, how the root system responds to abiotic stress has not yet been fully understood. A zinc finger protein gene, OsZFP350, is exclusively expressed in the rice root, but its biological function needs to be investigated. Expression of OsZFP350 was up-regulated by salt, drought and high temperature, indicating that it might be a regulator in response to abiotic stress in rice root. The primary root length, the number of adventitious and lateral roots was significantly increased in OsZFP350 transgenic plants when compared to the wild-type. In addition, our results also show that the up-regulated OsZFP350 could significantly increase the germination rate of seeds under abiotic stress, and attenuate the heat, salinity and drought stress during the development of rice roots. Based on these findings, it could be concluded that OsZFP350 plays a positive role in the adaptability of rice roots to abiotic stress.
Preventive effect of salicin ether against type-2 diabetes mellitus through targeting PPARγ-regulated gene expression
Authors: Zhu Guangping , Zhang Junxia , Yue Ling , Xiang Guangda
Published: December 2024

Diabetes mellitus is the syndrome associated with metabolism having complicated pathogenesis and its morbidity rate is rapidly increasing every year. The present study investigated the preventive effect of salicin ether against type-2 diabetes and explored the underlying mechanism. Salicin ether reduced PPARγ-LBD level and transcriptional property of RXRα-PPARγ in 293T cells. The rosiglitazone significantly (p<0.01) increased grease droplet accumulation in adipocytes in comparison to control adipocytes. Increased grease droplet accumulation by rosiglitazone in adipocytes was reversed on treatment with salicin ether in dose-dependent manner. Salicin ether treatment of the adipocytes effectively suppressed rosiglitazone induced expression of FAS, C/EBPα, aP2, and HMG-CoA genes. Treatment of the adipocytes with salicin ether led to a prominent decrease in rosiglitazone mediated increase in aP2, CHIP, and C/EBPα protein expression. The inhibitory effect of rosiglitazone on expression of p-Akt/t-Akt, PPARa, p-FoxO1/t-FoxO1, and p-AMPK/t-AMPK was significantly (p<0.01) alleviated in the adipocytes by salicin ether. In summary, the present study demonstrated that salicin ether suppressed PPARγ activity and adipocyte differentiation. Moreover, the activation of FoxO1/Akt/AMPK was up-regulated and FAS/EBPα/aP2/HMG-CoA level inhibited by salicin ether in the adipocytes. Thus, salicin ether may be studied further for possible role in the treatment of diabetes.
The XLIX Winter School of the Faculty of Biochemistry, Biophysics and Biotechnology of the Jagiellonian University – “Omics research – from methodology to application”. February 22nd–24th, 2022, Kraków, Poland
Authors: Dziga Dariusz
Published: December 2024

The XLIX Winter School of the Faculty of Biochemistry,Biophysics and Biotechnology of the Jagiellonian University–“Omics research – from methodology to application”.February 22nd–24th, 2022, Kraków, Poland
The Influence of Social Support on Customer Engagement in Live Streaming Commerce: The Mediating Role of Perceived Value
Authors: Li Long , Pongsakornrungsilp Siwarit , Pongsakornrungsilp Pimlapas , Jiang Yuanyuan
Published: December 2024

This research leverages social support theory to examine how informational and emotional support affect customer engagement in live streaming commerce (LSC), emphasizing the mediation effect of perceived value. Specifically, this study explores how these types of support influence perceptions of symbolic, utilitarian, and hedonic value. The study establishes its conceptual framework by analyzing 762 valid surveys from Chinese LSC consumers using SPSS and SmartPLS. Findings reveal that customer engagement is influenced by customers' perceptions of symbolic, utilitarian, and hedonic value in LSC, with social support significantly impacting perceived value. Notably, hedonic value is critical in LSC, mediating the interaction between customer engagement and both types of social support. These insights offer strategic guidance for sector professionals, highlighting the importance of fostering social support to enhance user engagement. The study also underscores the need for platforms and brands to focus on creating engaging and value-driven content to build a loyal customer base. By understanding the intricate dynamics of social support and perceived value, businesses can better navigate the evolving landscape of LSC.
National Security Strategy Considerations: Reflections on Zambia
Authors: M. MUKWENA AMB. PROF. ROYSON
Published: December 2024

In this paper, the author highlights the importance of a National Security strategy to the overall development and well-being of any country. The author observes that National Security has a direct bearing on the development process of a country as several forms of insecurity have the potential of disrupting and preventing the development process of any country.
The author argues that in a modern democracy the National Security Sector has an important role to play in defending the constitution and protecting the ideals of democracy. The author further argues that good governance is a critical element in ensuring a viable National Security Strategy.
Given the critical role national security plays in the development process of a country and the need to have a national security strategy in order to effectively and efficiently respond to various threats to national security, the paper highlights some of the critical National Security Strategy considerations to be taken into account in the formulation of a consolidated National Strategy.
The author concludes that, given the fact that the threats to national security in Zambia are numerous and interrelated, there is need to urgently put in place a consolidated national security strategy that can deal with the various threats in a more coordinated manner. The author finally concludes that there is a direct correlation between good governance and the various sources of insecurity.
Students’ Evaluation of The Academic Performance Through Interactive Multimedia Integration in A State College
Authors: Badong Alvin B.
Published: December 2024

This study, conducted at a Polytechnic State College in Camarines Sur, evaluates the effectiveness of interactive multimedia integration in enhancing students’ academic performance. This study employed a quantitative method using a quasi-experimental design. It evolves pilot testing with pre-tests and post-tests for two sections of BS Nursing students. Section A (control group) consisted of 51 students, while Section B (experimental group) had 47 students. Statistical tools, including independent sample t-tests and analysis of variance (ANOVA), were used to analyze and interpret the data.
The results revealed that the experimental group had a post-test mean score of 68.51, compared to the control group's 55.85. Statistical analysis confirmed a significant improvement in post-test scores for both groups, with the experimental group showing a greater mean difference of -16.29, indicating enhanced learning gains. Correlational analysis showed no significant relationship between pre-and post-test scores in Pair 1 (experimental group, r = 0.032, p = 0.822). In contrast, Pair 2 (control group) exhibited a statistically significant but weak negative correlation (r = -0.309, p = 0.035). Despite these differences, both groups demonstrated above-average performance before and after the intervention.
The findings suggest that integrating multimedia technologies fosters an interactive and engaging learning environment, leading to a statistically significant improvement in academic performance. This highlights the potential of multimedia as a valuable tool for enhancing the quality and effectiveness of instruction in classroom settings.
Razoabilidade e proporcionalidade na hermenêutica do direito público
Authors: Rosa Maria Fernanda Pereira , Simioni Rafael Lazzarotto
Published: December 2024

O presente artigo objetiva explicitar as diferenças estruturais e funcionais inscritas na história dos conceitos de proporcionalidade e razoabilidade, de modo a demonstrar as diferentes possibilidade e âmbitos de aplicação no campo dos direitos fundamentais e sociais. Trata-se de conceitos que ultrapassaram as discussões hermenêuticas e hoje encontram-se presentes tanto na legislação nacional positiva, quanto em precedentes judiciais e doutrinas jurídicas importantes, mas com significados contingentes e muitas vezes utilizados com finalidades retóricas. Assim, esse uso predominantemente retórico da proporcionalidade e razoabilidade obstaculizam as suas respectivas funções interpretativas, especialmente a proteção dos direitos fundamentais-sociais. Através do método analítico e a técnica de revisão literária sistemática, esta pesquisa conclui que razoabilidade e proporcionalidade, com suas diferenças tanto estruturais quanto funcionais, são importantes chaves interpretativas da nossa cultura jurídica, que transcendem o direito positivo e a dogmática jurídica para afirmar, em um nível metalinguístico, a proteção e realização prática dos direitos fundamentais-sociais.
Nano-Catalytic Synthesis of 5-Substituted 1H Tetrazole Derivatives and Biological Applications
Authors: Shekh Khdir Jwankar Abdulla , Aziz Dara , Qader Ibrahim , Meena Bashdar Ismael Meena , İbrahim Bnar Mahmoud
Published: December 2024

This review explores the innovative use of nano-catalysts in the synthesis of 5-substituted 1H-tetrazole derivatives, highlighting their significant biological applications. The novel methodologies discussed demonstrate enhanced efficiency and selectivity in the production of these compounds. Key findings include the optimization of reaction conditions and the discovery of new catalytic pathways that improve yield and reduce reaction time. The synthesized tetrazole derivatives exhibit strong potential as therapeutic agents due to their biological activity. This work provides a comprehensive overview of the state-of-the-art techniques in nano-catalytic synthesis, emphasizing their practical applications in medicinal chemistry and materials science.
Pro-life, Pro-Choice and everything in between: A quantitative study of popular attitudes on abortion in the Faroe Islands
Authors: Skorini Heini í , Albinus Herit
Published: December 2024

Having debated the rights of sexual minorities for two decades, the question of abortion is increasingly emerging as a new fault line in Faroese politics. In spring of 2024, the Faroese Parliament rejected the legalisation of free abortion by the slimmest margin possible, and civil society NGOs are spearheading “pro-choice” and “pro-life” campaigns. But how does the Faroese voter relate to the question? Who supports and who opposes the legalisation of free abortion before week twelve? On the basis of a quantitative survey conducted in November 2022, this article examines public opinion on abortion legislation and what demographic and personal factors predict abortion attitudes. While it is not possible to present conclusive evidence on the basis of one single study, the findings indicate that the Faroese public is divided on the issue. Furthermore, there is a positive correlation between pro-life attitudes and the importance of religion as well as right-wing attitudes, while centre-periphery tensions are also visible. However, and in contrast with international surveys in the cross-national literature on abortion and public opinion, the survey finds no difference between men and women, and educational level does not predict abortion attitudes either. Finally, when examining the role of age, the generation between 30-44 years proves most likely to oppose the legalisation of abortion on demand.
Úrtak
Eftir at hava kjakast um rættindi hjá seksuellum minnilutum í tvey áratíggju er ósemjan um abort ella fosturtøku vorðin alsamt sjónligari í føroyskum politikki. Á vári í 2024 atkvøddi ein tepur meiriluti ímóti nýggjari lóg, sum loyvir fríari fosturtøku, samstundis sum felagsskapir stríðast bæði fyri og ímóti rættinum til abort. Men hvat hugsar føroyski veljarin um hendan spurning? Hvør er fyri og hvør er ímóti fríari abort áðrenn 12. viku? Við støði í kvantitativari kanning frá november 2022 kannar hendan greinin almennan hugburð til abort og hvørji demografisk og persónlig viðurskifti mynda hugburð til hendan spurning. Uttan at draga ov greiðar niðurstøður við støði í einstøkum kanningum geva úrslitini ábendingar um, at føroyskir veljarar eru sera ósamdir. Hagfrøðiliga finst ein signifikantur samanhangur millum átrúnað, høgravendan hugburð og mótstøðu ímóti fríari abort, samstundis sum munirnir millum miðstaðarøkið og økini kring landið eisini eru sjónligir. Men í andsøgn til gransking aðrastaðni finst eingin signifikantur munur á monnum og kvinnum, og útbúgving hevur heldur ongan týdning. Viðvíkjandi aldri er aldursbólkurin millum 30 og 44 ár í størri mun ímóti fríari abort samanborið við aðrar aldursbólkar.
Inclusive education as human rights for immigrant students in Faroese compulsory schools – a desktop study of Faroese policy documents and current Faroese research in the field
Authors: Vijayavarathan-R. Kalpana
Published: December 2024

The desktop article studies the status quo regarding the inclusion of immigrant children in Faroese compulsory schools as a human rights issue through analysis of policy documents, relevant official documents and Faroese research in the field of inclusive education for the target demographic. Using content analysis, an attempt is made to study whether the policies are socially just, equitable and fall within the human rights of immigrant children to equitable access to education. The policies are evaluated using the language orientation framework (Ruiz, 1984) to elicit the policy stance towards immigrant children.  
Existing research on Faroese educational policies for inclusion in education is used to determine if fit-for-purpose educational measures exist for immigrant children to learn Faroese, fulfil learning outcomes and integrate into the society while retaining their own first language and culture. It appears that language-as-problem dominates policy stance, and its implementation without consideration for the human rights of these children has potential implications for their integration and their becoming meaningful, full-fledged members of Faroese society.   
Úrtak
Í greinini verður inklusjón sum mannarættindi hjá tilflytarabørnum í føroyska fólkaskúlanum kannað. Kanningin umfatar greining av útbúgvingarpolitiksskjølum, viðkomandi almennum skjølum og føroyskari gransking um inkluderandi útbúgving fyri hesar tilflytaranæmingar.  Við støði í innihaldsgreiningum verður roynt at kanna, hvørt politikkurin er sosialt grundaður, rættvísur og lýkur mannarættindakravinum hjá tilflytarabørnum um rættvísa atgongd til útbúgving. Politikkurin er eftirmettur við støði í karminum um málstøðu (language orientation) (Ruiz, 1984) til tess at fáa støðuna hjá tilflytarabørnum fram í ljósmála.
Gransking, sum fevnir um føroyskan útbúgvingarpolitikk og inklusjón í útbúgving, er nýtt til at gera av, hvørt hóskandi útbúgvingarmál eru til taks hjá tilflytarabørnum at læra føroyskt, lúka læruúrtøkur og fella inn í samfelagið, samstundis sum tey varðveita sítt egna móðurmál og mentanina í upprunalandinum. Úrslitini benda á, at sjónarmiðið mál-sum-trupulleiki (language-as-problem), er ráðandi, og útinningarstigið ikki hevur fyrilit fyri, at mannarættindastøðan hjá børnunum hevur møguligar avleiðingar fyri integrasjónina í føroyska samfelagið og teirra møguleikar at gerast týðandi, fullbúnir limir í føroyska samfelagnum.
Towards a New Approach to External Public Audit in Romania — A Brief Essay
Authors: Bostan Ionel
Published: December 2024

Our paper analyzes recent transformations in the field of external public auditing in Romania, with a particular focus on the transition toward a modern, performance-oriented approach aimed at improving processes. The reforms initiated by the Romanian Court of Accounts aim to adopt best international practices, moving away from traditional coercive methods such as „error hunting” and a focus on sanctions. The proposed „pure” auditing approach emphasizes the formulation of actionable recommendations and effective measures, grounded in professional missions and rigorous performance analysis. The paper also highlights the progress made in increasing the transparency of the Court of Accounts' activities, including the development of guidance mechanisms and uniform practices for external auditors and audited entities. In the context of accelerated digitalization, the institution has implemented modern solutions for data collection and processing, contributing to the prompt drafting of reports and providing better assistance to beneficiaries. These developments position Romania's external public auditing on an upward trajectory, with the potential for alignment with the standards of similar institutions in advanced countries, while also offering substantial support to the majority of good-faith entities. To capture the new directions adopted in external public auditing in Romania, after this brief Introduction (1), we focus on the issue of The renunciation of the jurisdictional function of the Court of Accounts (2) and the topic of Breaking away from the past through continuous reform measures (3), concluding with a Conclusions section (4).
Impact of iPads on secondary school children’s learning from the teachers’ perspective
Authors: Kaulanov Magzhan , Kazimova Dinara
Published: December 2024

This article explored the impact of iPad-based learning on secondary school children's motivation and engagement with school subjects. The use of iPads in the classroom has become increasingly common in recent years, with many schools incorporating this technology into their curricula. However, there is a lack of research on the specific impact of iPad-based learning on student motivation and engagement. To address this gap in the literature, the present research conducted a study with a sample of secondary school students to assess the effects of iPad-based learning on motivation and engagement. The results indicated that iPad-based learning had a positive impact on both motivation and engagement, with teachers reporting increased interest and enjoyment of the students in their school subjects when using iPads in the classroom. These findings suggest that iPad-based learning has the potential to enhance student learning experiences and support student success in school. This article tried to find out the impact of using iPads on students’ motivation and engagement among Kazakhstani secondary school teachers.
Keywords: Education technology; iPads; learning; motivation; students
STRATEGI PONDOK PESANTREN DARUL ULUM BANYUANYAR DALAM MEMBANGUN IMAGE BRANDING DI MEDIA SOSIAL
Authors: Ghazali Ziyadul Ifdhal , Nasrullah
Published: December 2024

Sekolah saat ini dipandang sebagai perusahaan penyedia jasa pendidikan. Sebagai perusahaan, masyarakat sudah tidak lagi dipandang sebagai user pendidikan melainkan costumer pendidikan. Akibatnya, muncul persaingan antar lembaga pendidikan untuk mendapatkan costumer (siswa) sebanyak-banyak. Penelitian memiliki misi untuk mengetahui strategi yang digunakan oleh pondok pesantren Darul Ulum Banyuanyar Pamekasan dalam membangun image branding melalui media sosial di masyarakat. Metode yang digunakan dalam penelitian ini adalah pendekatan analisis deksriptif kualitatif. Metode yang digunakan dalam penelitian ini adalah pendekatan analisis deksriptif kualitatif. Ada dua data primer yang digunakan, yaitu aktivitas pondok pesantren Darul Ulum Banyuanyar di media sosial seperti Facebook, Instagram, Twitter (X), Youtube, dan Tiktok dan wawancara. Penelitian menunjukkan jika pondok pesantren Darul Ulum Banyuanyar menggunakan media sosial untuk tiga hal, sebagai media dakwah dan edukasi, media komunikasi dan informasi pondok pesantren, dan membangun image branding pondok pesantren di masyarakat. Demi mencapai ketiganya, pondok pesantren membentuk tim media sosial yang terdiri dari konten kreator dan pengawas untuk membangun image branding pondok pesantren.
STRATEGI KOMPETENSI MANAJERIAL DAN SUPERVISI PENDIDIKAN DALAM MENINGKATKAN PROFESIONAL GURU
Authors: Syarif Hidayatullah  , Yusrianti Susi
Published: December 2024

Strategi kompetensi manajerial kepala sekolah dan supervisi pendidikan merupakan faktor penting dalam upaya peningkatan profesionalisme guru. Kompetensi manajerial kepala sekolah yang meliputi kemampuan merencanakan, mengorganisasi, mengkoordinasikan, mengontrol, serta mampu memanfaatkan sumber daya sekolah secara maksimal turut berperan dalam memberdayakan guru untuk meningkatkan kompetensinya. Penelitian ini berjenis kualitatif dengan metode kepustakaan. Informasi dikumpulkan lewat referensi yang relevan buat dianalisis semacam mengumpulkan informasi dengan mengenali wacana dari bermacam rujukan semacam buku-buku, makalah ataupun postingan, jurnal, internet (website) ataupun informasi lain berbentuk data, majalah serta lain sebagainya yang berkaitan dengan strategi kompetensi manajerial dan supervisi pendidikan dalam meningkatkan profesional guru. Upaya peningkatan profesionalisme guru yang dilaksanakan secara terpadu antara kompetensi manajerial kepala sekolah dan supervisi pendidikan diharapkan mampu meningkatkan kualitas pembelajaran sehingga tujuan pendidikan dapat tercapai. Dengan demikian, strategi tersebut akan memberikan kontribusi positif terhadap peningkatan mutu pendidikan secara keseluruhanperlu adanya komitmen bersama antara kepala sekolah dan guru untuk terus meningkatkan kompetensi masing-masing secara profesional demi peningkatan mutu pendidikan. kinerja guru sangat menentukan dalam kualitas hasil pendidikan, karena guru merupakan pihak yang paling banyak bersentuhan langsung dengan peserta didik dalam proses pembelajaran disekolah.
MANAGEMENT OF QUALITY IMPROVEMENT IN LEARNING BASED ON DIGITALIZATION AT MADRASAH UMMUL QURO AT-TARBAWIYAH PUTRI PLAKPAK PEGANTENAN PAMEKASAN
Authors: Fahmi Ach. Syafiq Fahmi , Fathor Rosid  , Ali Nurhadi  , Abdul Aziz  , Abdul Wahid
Published: December 2024

This research aims to explore the implementation, results, and supporting and inhibiting factors of digitalization-based learning quality improvement management implemented at Madrasah Ummul Quro At-Tarbawiyah Putri. This research was conducted using a qualitative model with a variety of case study approaches. The results of this research show that the implementation of management to improve the quality of digitalization-based learning at Madrasah Ummul Quro At-Tarbawiyah Putri was carried out in three stages, namely planning, implementation and evaluation. The results of the management of improving the quality of digitalization-based learning are very visible, it is easier for teachers to convey learning, and female students can easily understand lessons related to visualization. Supporting factors in improving the quality of digitalization-based learning include developments in digitalization and the demands of the times, the availability of digital technology, and full support from the boarding school leadership, as well as the enthusiasm of the teacher council in improving the quality of learning. Meanwhile, the inhibiting factors are that the cost of providing digital facilities is very expensive, and teachers' digital literacy abilities are uneven.
CHANGE MANAGEMENT OF TAHFIDZ KHAIRUNNAS SRESEH SAMPANG ISLAMIC BOARDING SCHOOL AS A STRATEGIC EFFORT TO DEVELOP INSTITUTIONAL QUALITY
Authors: Soleh Badrus , Wahyudi Kacung , Buna'i  , Karofis Shofiatul , Masrurah Waqiatul
Published: December 2024

This research aims to describe the change management of the Tahfidz Khairunnas Sreseh Sampang Islamic Boarding School which includes planning, implementation and control systems. This research uses a qualitative approach with a case study type. Data sources were obtained through interviews, observation and documentation. Informants include the Islamic boarding school manager, dormitory head/caretaker, and mudabbir. Meanwhile, data analysis is carried out through condensation, presentation and conclusions. The results of this research show that the planning for changes to the Tahfidz Khairunnas Islamic boarding school includes planning for takhassus and non-takhassus programs, student targets that are clearly arranged in the Sikhair application system, financing with two types, namely regular and scholarships, sophisticated teaching and learning facilities such as tablets and projectors, a clear vision and mission. created from the center, as well as gel system planning. The implementation of changes in Islamic boarding schools includes the implementation of the vision and mission carried out with collaboration (internal and external), the use of the tasmi', ziyadah and murojaah curriculum, and the application of the cultures found in Islamic boarding schools. Meanwhile, controlling changes in Islamic boarding schools is by implementing the Trello application as a performance control system, implementing the Sikhair application, and holding regular ten-minute meetings every day.
Plantations forestières en Afrique tropicale sèche. Techniques et espèces à utiliser : 3e partie : techniques à utiliser de la plantation à l’exploitation et aux rejets
Authors: Delwaulle J.C.
Published: December 2024

La plantation ayant été réalisée, ce troisième volet traite des techniques à employer jusqu'à la récolte.Naturellement, les plants doivent être protégés contre les animaux et l'entretien doit être mécanique ou manuel, selon l'ampleur du projet.La méthode taungya ne doit pas être utilisée la première année et lorsque les précipitations annuelles sont inférieures à 1 000 mm Des voies d'accès et des coupe-feux contribueront à lutter contre les incendies. Des essais sont en cours concernant la fréquence des éclaircies, l'irrigation et l'âge de la récolte. En moyenne, trois ou quatre rejets doivent être conservées afin d'utiliser toute la potentialité nutritionnelle de la souche.
Louis Bégué : hommage
Authors: Chollet A.
Published: December 2024

Pas de résumé
The Effectiveness Of Red Power Injection On The Hematological Profile Of Layer Chicken (Gallus domesticus)
Authors: Lazwari Rahamaddanu Surya , Yasmin Anandira Dania , Lutfiah Fatun Latifa , Fahmi Zarkasya Zahra Nur Saffanah , Nugroho Zatya Dimas Prakoso , Dewa Gogod Wahyu , Eros Easter Palma Dewi , Fadhila Azzahra Shafa Fadhila
Published: December 2024

Layer chickens are one of the most popular types of mass-produced laying hens in Indonesia. One way to keep laying hens healthy is to fulfill their micronutrient and vitamin needs. Giving vitamins such as Red power injection is very good for broilers, layers and fighters. Red power injection contains extra liver which contains vitamin B12, folic acid, and iron which are useful for maintaining chicken health. In this study, researchers wanted to test the effectiveness of Red power injection supplements in increasing blood in laying hens (Gallus domesticus). The study used an experimental research method using two treatments for one day. Four laying hens (Gallus domesticus) that have been provided are divided into two treatment groups with a dose of group one 0.8 ml / head and a dose of group two 1.2 ml / head. The variable observed was the increase of Hematology Profile (Erythrocytes, Leukocytes, and Hemoglobin). The results showed an increase in the Hematology Profile tested. The increase in the Hematology Profile is due to the effect of nutrition on chickens has been fulfilled, Red power injection is a supplement containing liver extract which helps the formation of Hematology Profile in Laying Hens (Gallus domesticus).
Orthopedic Surgery Meets Serious Illness Care: Palliative Care and Advance Care Planning for the Orthopedic Surgeon
Authors: Mand Davinder , Mand Donya , Kilpatrick Laurel , Probe Robert A.
Published: December 2024

» Advance care planning and palliative care can improve care for orthopedic patients.

» The “surprise question” is a useful prognostication tool and trigger for palliative care referral.

» Engage in routine advance care planning conversations.

» Confirm code status before surgery.

» Any surgeon can determine capacity and need for a surrogate decision maker.
Evaluation of the Food Security Program in Sidoarjo Regency
Authors: Rustianingsih Eni
Published: December 2024

The increase in Indonesian rice imports in 2023 reflects a shortage in the supply of rice food. The irony is that Indonesia is an agricultural country that wants to be self-sufficient in food. To achieve this, good synergy is needed between the Central Government and Regional Governments, including the Sidoarjo Regency Government. This research aims to evaluate the food security program implemented in Sidoarjo Regency, with a focus on the availability of rice and obstacles in meeting food needs. The method used is qualitative research with a library research approach, which involves collecting data through observation and documentation. The research results show that the availability of rice in Sidoarjo Regency will fluctuate from 2018 to 2024, with total rice production reaching 195,855 tons of GKG in 2023. Even though there is a rice surplus of 117,451 tons, challenges such as land conversion and unfavorable weather conditions remain obstacles in increasing agricultural productivity. The conclusions of this research emphasize the need for integrated policies and community support to increase rice food security in Sidoarjo Regency, as well as the importance of ongoing evaluation of existing programs to ensure the sustainability of food supplies in the future.
DISBIOSE DO TRATO GASTROINTESTINAL E DOENÇA DE ALZHEIMER
Authors: BACIUK-SOUZA LETICIA , PASSOS BACIUK ERICA , Do Amaral Toma Marízia
Published: December 2024

Resumo: Esta revisão integrativa teve por objetivo verificar as associações possíveis entre disbiose intestinal e Doença de Alzheimer (DA). Foi realizada busca sistematizada nas bases de dados Medline, Lilacs, PubMed e Scielo, com os termos Alzheimer’s disease, Gut microbiota e Neuroinflammation. A patogênese da DA apresenta alta relação com a imunidade.  Os pacientes com DA têm diferenças significativas na taxonomia microbiana intestinal, com diminuição de inúmeras bactérias Gram-positivas, e aumento de várias Gram-negativas. Dentre os mecanismos envolvidos na patogênese estão: liberação de moduladores inflamatórios, proteína beta-amilóide (Aβ) e outras substâncias neurotóxicas, que induzem a neuroinflamação; aumento da permeabilidade das membranas no trato gastrointestinal e na barreira hematoencefálica, facilitando o aumento da agregação Aβ e lipopolissacarídeos, redução de ácidos graxos de cadeia curta (SCFAs) e baixos níveis de ácido γ-aminobutírico (GABA); excitotoxicidade do glutamato associada à neurodegeneração tardia; diferença nos níveis de aminoácidos e SCFAs, associando o APOE4 à DA. Conclui-se que os principais mecanismos de associação entre disbiose e DA envolvem acumulado de Aβ e emaranhados neurofibrilares, astrogliose associada à ativação microglial, neuroinflamação, estresse oxidativo e lesão de neurônios colinérgicos. E, apesar da disbiose ser associada a fatores genéticos, tem aumentado o número de estudos relacionando-a a fatores comportamentais como dieta, uso excessivo de antibióticos e disfunções metabólicas passíveis de controle.
SPECIFICS OF LATE HOLOCENE SEDIMENTATION IN THE CHUKCHI SEA INFERRED FROM GRAIN SIZE AND MINERALOGICAL ANALYSES OF BOTTOM SEDIMENTS
Authors: Vologina E.G. , Kolesnik A.N. , Kolesnik O.N. , Selyutin S.A.
Published: December 2024

The aim of this work is to elucidate the specifics of recent sedimentation in the Chukchi Sea, based on the study of the material composition of Late Holocene bottom sediments. Analytical methods included grain size and mineralogical analyses. The results of 210Pb and 137Cs dating were used. The sediments are clayey silt and silty clay containing sand admixture and single gravel grains and pebble. The content of coarse-grained material increases slightly in the upper parts of the studied sections. This is probably due to the greater contribution of ice rafting to the recent Chukchi Sea sedimentation as a result of climate warming. The ultrafine- and fine-grained (0.25–0.05 mm) sandy material is dominated by light-fraction minerals. Volcanic glass was discovered in the sediments sampled in the southern and central areas of the Chukchi Sea. It might have been transported from the volcanoes of Alaska, the Aleutian Islands, and the Kamchatka Peninsula through the Bering Strait by the Pacific currents directed from south to north. The sediments collected in the southern, central, and northern areas of the Chukchi Sea differ in grain size and mineral composition. This is probably due to their remoteness from the coastline and provenance areas and is also caused by different rates of sedimentation.
Reacciones psicológicas en población española derivadas del confinamiento por COVID-19.
Authors: Pérez Requena Adriana , Rodríguez de Santos Lucía , Velardo Tierno Jessica , Pablos Vida Rafael , Catalina Fernández Cristina , Franco Martín Manuel Ángel
Published: December 2024

Background and purpose: The measures adopted to control the COVID-19 pandemic cause emotional difficulties and have a significant psychosocial impact on the population. This research was conducted with the aim of exploring possible psychological effects, understood as symptoms of anxiety and depression, experienced in the confined population in Spain, as well as knowing the mediating role played by demographic variables. Method: A sample of 452 participants was recruited and administered an online questionnaire about anxiety symptoms (GAD-7 scale) and depression (PHQ-9 Questionnaire), as well as demographic variables. Two measures were made, the first between 30 March and 5 April, and the second between 13 and 21 April. The statistical package SPSS v.21 was used for the analysis of the results. Results: The results of the second measure reveal that around 30% of the population had moderate or severe symptoms of anxiety and depression within 30 days of confinement. These were higher in women, students, residents in an interior flat, those who saw their income decreased or those with a history of mental health. On the other hand, being over 56 years old, having higher education or living with a person, was related to lower levels of symptoms. Conclusions: The Spanish population experienced anxiety and depression reactions after a month of home confinement. Demographic variables acted as modulators of these effects.
Pseudoisotherm: A Revised Concept of Desorption Phenomena of Coalbed Gas Reservoirs Integrating Isotherm, Material Balance, and Pressure for Optimized Field Development
Authors: Parida B. P. , Sinharay R. , Upadhyay R. , Dixit M.
Published: December 2024

Gas in the coal is found mainly in the form of adsorbed methane on the surface of micropores. Methane desorbs and diffuses from micropores to cleat systems; then, the cleat network delivers the gas to the wellbore. The Langmuir isotherm empirically explains this phenomenon, a plot between pressure and adsorbed gas content (GC). The isotherm is generated in a laboratory, indicating how a particular reservoir will desorb the gas from the coal surface with a reduction in pressure throughout the production stage from startup to abandonment. This study aims to validate the laboratory-derived isotherm after a few years of field production, impacting the revised development plan for infill wells.

Assuming that the initially established isotherm is correct, the difference between the initial and current adsorbed gas volume should match closely with the produced gas volume. However, production analysis after 5 years indicates that the calculated produced gas volume is significantly higher than the observed, thus invalidating the fundamental material balance equation. This triggers the question: What is wrong with using the initially established adsorption isotherm in recovery calculations of depleted coal reservoirs, and how can it be corrected?

This necessitates revision/review of isotherms to match current pressure and GC/gas in place (GIP = area × current GC × thickness × density). As explained before, for coalbed methane (CBM) reservoirs, GC, cumulative gas production, and current reservoir pressure are direct measurements and require a solid logic to change the parameters. On the other hand, a Langmuir isotherm is a laboratory-derived isotherm from a representative sample of coal with inherent uncertainties from sampling to measurement. Hence, the isotherm shape is modified based on production data analysis and associated material balance results.

Considering all these empirical calculations, the laboratory isotherm is revised to satisfy both initial and current reservoir conditions. This solution is validated with hard field data in the form of new core holes drilled after 3 years of production. The pressure and GC measured in those core holes were plotted, which matched the pseudoisotherm, validating the new concept.

Instead of using the laboratory-derived core-scale isotherm throughout field life, it is modified with respect to production data analysis and material balance to make it a field-scale isotherm. In the coalbed gas or CBM industry, a new name is coined as “pseudoisotherm” to differentiate it from laboratory-derived isotherm. This method can be used in other reservoirs to optimize field development through infill wells during the production stage and unlock the full potential of coal-gas reservoirs.
The incidence and influencing factors of suicide attempts in major depressive disorder patients comorbid with moderate-to-severe anxiety: a large-scale cross-sectional study
Authors: Ren Lina , Dong Yeqing , Zhang Chuhao , Gao Jiajia , Zhang Xiao , Zeng Min , Luo Guoshuai , Zhang Xiangyang
Published: December 2024

Background
Major depressive disorder (MDD) is a recurrent and persistent mental illness. However, there is a lack of research that distinguishes the severity of comorbid anxiety disorders in MDD, and insufficient evidence exists regarding the prevalence of MDD patients with comorbid moderate-to-severe anxiety in the Chinese population.
Methods
The study included 1718 MDD patients (894 with moderate-to-severe anxiety symptoms and 824 without moderate-to-severe anxiety symptoms). Clinical symptoms and development were assessed using the Hamilton Depression Rating Scale-17 (HAMD-17), Hamilton Anxiety Rating Scale-14 (HAMA-14), Positive and Negative Syndrome Scale (PANSS), and Clinical Global Impression (CGI). The blood pressure and thyroid hormone levels were measured.
Results
We found that the incidence of MDD patients with moderate-to-severe anxiety symptoms was 52.04%. The prevalence of suicide attempts in MDD comorbid moderate-to-severe anxiety patients was 31.8%, which was 4.58 times higher than that in patients without moderate-to-severe anxiety. Additionally, suicide attempters had elevated levels of thyroid stimulating hormone (TSH), anti-thyroglobulin (TgAb), thyroid peroxidases antibody (TPOAb), systolic blood pressure (SBP), and diastolic blood pressure (DBP) compared to non-suicide attempters. We further identified CGI score, TSH, TPOAb, and DBP as influential factors for suicide attempts in MDD individuals who had moderate-to-severe anxiety symptoms. These indexes could distinguish between suicide attempts and non-suicide attempts in MDD patients with moderate-to-severe anxiety symptoms.
Conclusions
Our findings mainly indicated a high prevalence of suicide attempts in MDD patients with moderate-to-severe anxiety. Several clinical correlates, thyroid hormones, and blood pressure might contribute to suicide attempts in MDD patients with moderate-to-severe anxiety symptoms.
Machine learning models predict the progression of long-term renal insufficiency in patients with renal cancer after radical nephrectomy
Authors: Yan Yongchao , Sun Qihang , Du Haotian , Guo Yize , Li Bin , Wang Xinning
Published: December 2024

Background: Chronic Kidney Disease (CKD) is a common severe complication after radical nephrectomy in patients with renal cancer. The timely and accurate prediction of the long-term progression of renal function post-surgery is crucial for early intervention and ultimately improving patient survival rates. Objective: This study aimed to establish a machine learning model to predict the likelihood of long-term renal dysfunction progression after surgery by analyzing patients’ general information in depth. Methods: We retrospectively collected data of eligible patients from the Affiliated Hospital of Qingdao University. The primary outcome was upgrading of the Chronic Kidney Disease stage between pre- and 3-year post-surgery. We constructed seven different machine-learning models based on Logistic Regression (LR), Support Vector Machine (SVM), Random Forest (RF), Extreme Gradient Boosting (XGBoost), Light Gradient Boosting Machine (Lightgbm), Gaussian Naive Bayes (GaussianNB), and K-Nearest Neighbors (KNN). The performance of all predictive models was evaluated using the area under the receiver operating characteristic curve (AUC), precision-recall curves, confusion matrices, and calibration curves. Results: Among 360 patients with renal cancer who underwent radical nephrectomy included in this study, 185 (51.3%) experienced an upgrade in Chronic Kidney Disease stage 3-year post-surgery. Eleven predictive variables were selected for further construction of the machine learning models. The logistic regression model provided the most accurate prediction, with the highest AUC (0.8154) and an accuracy of 0.787. Conclusion: The logistic regression model can more accurately predict long-term renal dysfunction progression after radical nephrectomy in patients with renal cancer.
The role of spatial planning in strengthening human settlement resilience to natural disasters in Chimanimani District, Zimbabwe
Authors: Zivhave Morgen , Chatiza Kudzai , Bvuma Tendai , Zimunya Willoughby , Musvoto Godfrey
Published: December 2024

The effectiveness of spatial planning in guiding human settlements has come under increasing scrutiny with the increasing occurrence and severity of climate-induced disasters. This study interrogates the role of spatial planning in promoting resilient settlements in rural service centres, often overlooked in favour of large cities and towns. Our study adopted mixed methods research and collected quantitative data using questionnaires from households and qualitative using detailed semi-structured interview guides from key informants from Chimanimani District and national government departments/agencies. Findings show that spatial planning responses to climate change impacts are negatively affected by institutional capacity gaps within the Chimanimani Rural District Council and the District Development Coordinator’s office to plan and implement resilience strategies. District institutions are stifled by direct planning and implementation of projects by the national government which bypasses, duplicates and denies district stakeholders the opportunity to learn and develop capacity. The rigid spatial planning standards, the flouting of planning guidelines, the parcelling of land by traditional leadership, and political interference contributed to poor district spatial planning for resilient human settlements. We recommend a framework for spatial planning for resilience that taps local and scientific knowledge to evolve strategies, through decentralised institutions, to enforce environmentally sensitive standards.
Investigating the Effect of Parameters in the Thermodynamic Analysis of the Solid Oxide Fuel Cell Cycle Using Response Surface Methodology
Authors: Ghaebi Hadi , Soleymani Elahe
Published: December 2024

In this article, the effect of parameters in the solid oxide fuel cell cycle has investigated using the response surface method. The thermodynamic modeling of this cycle has been done by EES software, which by considering three variables (current density, molar flow rate and fuel cell temperature) as input parameters, to examine the mutual effects of parameters on the objective functions (net output power and exergy efficiency) using the experimental design method. According to the results of thermodynamic analysis, the net power output and exergy efficiency of solid oxide fuel cell are 2424 kW, 52.29% and 50.43%, respectively. By transferring the tests based on the central composite design for the parameters obtained by the Design Expert software, the extracted results show the interaction effect of the input parameters. According to the results of the regression analysis, the values ​​of R2 in the responses of net output power and exergy efficiency are 96% and 87.79%, respectively, which shows the accuracy of the model. The parameters have a good interaction effect with each other and the optimal points for the input parameters of current density (i), input methane molar flow rate (nCH4) and solid oxide fuel cell temperature (TSOFC) has been calculated at the points of 2311.53 A/m2, 0.0068 kmol/s and 1200 K, as well as the responses of net output power and exergy efficiency at points 3555.18 kW and 0.68345%.