bluuebunny/crossref_metadata_2025 huggingface dataset:
Genius Learning and Think Talk Write Reviewed from Junior High School Students’ Creativity
Authors: Wibowo Adi Ari , Rif'at Mohamad , Yani Ahmad
Published: July 2023

The study aimed to obtain information about comparing student learning outcomes, given the genius learning strategy and think talk write in terms of student creativity. The study was a quasi-experimental design and the research design was a 2x3 factorial design. The population in this study were all students of VIII grade at SMP Negeri 1 Sepauk, with a sample of VIIIC and VIIID grades who were randomly selected using cluster random sampling technique. Based on the results of data processing, the following conclusions were obtained: (1) The learning outcomes between students who were given a genius learning strategy were relatively the same as think talk write, both in general and based on the student's creativity category, (2) The learning outcomes between students who had relatively high creativity the same as students who have medium or low creativity, and students with moderate creativity have relatively the same learning outcomes as students who have low creativity both in general and in terms of learning strategies. Keywords: Creativity, Genius Learning, Think Talk Write
ANALYSIS OF BASE SUBSECTORS AND LEADING AGRICULTURAL COMMODITIES IN SEKADAU REGENCY, WEST KALIMANTAN PROVINCE
Authors: R Hernovianty F , B Soeryamassoeka S , Komala Erwan , Elsa Mukti Tri , Erni Yuniarti
Published: July 2023

The contribution of agriculture which has increased each year has been encouraged to be a strategic area for the economic development of Sekadau Regency. However, weakness of planning policy, insufficient quantity, and quality of infrastructure are obstacles to developing strategic areas. This study aims to analyze the basis of sub-sectors and leading commodities of agriculture in Sekadau Regency. The research approach used an exploratory qualitative with descriptive analysis methods to get an overview of agricultural productivity and Location Quotient Analysis, Shift-Share Analysis, and Klassen Typology to get the leading commodities of agriculture. The results of the study show that the productivity level of the agricultural sub-sector in Sekadau Regency is quite diverse. The agricultural and progressive sub-sector in Sekadau Regency is owned by food crops and plantations. Furthermore, the leading commodities of the food crop sub-sector in Sekadau Regency are corn, rice, and sweet potatoes. The main commodities of plantation sub-sectors in Sekadau Regency are pepper, rubber, and oil palm.
Energy Management and Economic Considerations of Intermittent Photovoltaic-Driven Electrochemical Ammonia Production
Authors: Varanasi Sai , Fernandez Carlos , Hatzell Marta
Published: July 2023

As the energy sector shifts from fossil fuels to renewable energy, there is a need for long-duration energy storage solutions to handle the intermittency of renewable electricity. Electrofuels, or fuels synthesized from excess electricity, are an emerging medium poised to meet long-duration energy storage requirements. Ammonia as an electrofuel is potentially ideal because ammonia has a relatively low liquefaction pressure, indicating that ammonia can be easily stored and transported. Here, we develop a framework to optimize the electrochemical production of ammonia powered by intermittent photovoltaic power. We also explore various buyback policies to understand the impact that policy has on the cost of intermittent ammonia and optimal sizing ratios. The optimal ratio of the photovoltaic to the electrolyzer is ~3.7 MW$_{PV}$/MW$_{ELEC}$ for an system that is completely powered by renewable photovoltaic power and operates intermittently. The optimal ratio of the photovoltaic to the electrolyzer is ~3.3 MW _PV/MW_Elec for a system that uses photovoltaics in conjunction with grid electricity and operates continuously. For the purchase price at the avoided cost of electricity, the optimal ratio of the solar panel to the electrolyzer increases to ~4 MW _PV/MW_Elec for a system that can only sell to the grid and ~5 MW_PV/MW_Elect for a system that can buy and sell electricity to the grid at the avoided cost. Optimizing energy management by setting auxiliary battery size limits is essential to reduce ammonia cost, and the optimal battery size decreases as the buyback price of electricity increases. Finally, we find that systems connected to the grid and operating continuously have emissions comparable to the Haber-Bosch process because of the current emissions tied to the United States electricity generation. Thus, unless the grid is completely decarbonized, it is essential to create electro-fuels that rely minimally on grid electricity.
Description of solvatochromism of peak broadening in absorption spectra in solution using the reference interaction site model self-consistent fields spatial electron density distribution
Authors: Negishi Naoki , Yokogawa Daisuke
Published: July 2023

We quantified and subsequently analyzed bandwidth of ultraviolet and visible photoabsorption spectral lines in solution by applying time-dependent first-order perturbation theory using the Born-Oppenheimer adiabatic potential calculated using the multi-state extended-multiconfigurational quasidegenerated second-order perturbation theory (MS-XMCQDPT2) coupled with the reference interaction site model self-consistent field spatial electron density distribution (RISM-SCF-cSED). The proposed method was implemented for 2-thiocytosine in solution, and solvatochromism of the bandwidth of the πSπ∗ transition was clearly observed. The standard deviation of a characteristic electronic excitation was decomposed into the contributions of the characteristic vibrational mode of 2-thiocytosine. The main vibrational modes 1 contributing to peak broadening were found to be for acetonitrile, methanol, and the aqueous phase. We concluded that the mechanism for peak broadening is qualitatively different for phases of protic and aprotic solvents because of the structural variation in 2-thiocytosine driven by breakage of the resonance structures.
Aportes a la síntesis de mecanismos de Lung-Wen Tsai, contextualización contemporánea y propuesta de aplicaciones
Authors: Osejo-Bucheli Camilo
Published: July 2023

Resumen— Introducción: Las ciencias aplicadas, y las artes aplicadas estudian diseño de mecanismos en diferentes niveles de complejidad. Se ha avanzado en la literatura académica metodológicamente, una de estas orientaciones del diseño, es la síntesis de mecanismos, la cual permite avanzar en un proceso de diseño sistemático. Problema: se carece de un texto en castellano que presente los métodos de síntesis de mecanismos para el diseño. Existen textos que abarcan el tema de manera demasiado extensa como para presentarla rápidamente a un profesional en formación. Objetivo: traducir de forma fidedigna y sucinta los tipos de síntesis que compiló el profesor Tsai, y presentarlas en un artículo que cite también los desarrollos en el tema posteriormente a la publicación seminal de Tsai. Metodología: se usa la exegesis textual y el análisis documental para construir una propuesta completa y sistemática. Resultados: un artículo que contiene procesos para síntesis de mecanismos necesarios para el diseño, sucintos, completos y con referencias actualizadas. Conclusión: los métodos de síntesis de mecanismos son de aplicación intuitiva y no requieren formación ni preparación previa para aplicarla. Este documento es suficiente para facilitar a los profesionales en formación la aplicación de la síntesis de mecanismos. Originalidad: si bien el documento es una traducción, el artículo da respuesta a una necesidad epistemológica en las áreas de conocimiento antes citadas, con alusiones a publicaciones actualizadas. limitaciones: la síntesis de mecanismos es útil para el diseño, existen otros procesos mentales diferentes que no se tratan aquí.
Clinical Recommendations to Improve Utilization of Fissure Sealants in Primary Healthcare Centers in Bahrain
Authors: Flaihan Alrowaili Eman
Published: July 2023

A situation analysis among which a cross-sectional survey of dental practitioners working in primary healthcare centers found that while 127 (94.8%) out of 134 respondents consider fissure sealants effective yet, most of them have misconceptions regarding which teeth to consider carious and which to seal as only 15 (11.2%) recognized that initial carious and non-cavitated carious lesions are the same and only around half sealed either. Fissure sealants are provided for free in primary healthcare centers, but they seem underutilized as only 35 (37.6%) dentists use them very often. To address these issues and others raised by dentists and dental hygienists on the indications and the use of fissure sealants; evidence-based clinical recommendations are provided keeping in mind the high level of caries among children and adolescents in Bahrain and the services provided in primary healthcare centers. Further studies will be needed to evaluate different reasons affecting dental practitioners' knowledge and use of fissure sealants as a method of preventing and controlling caries.
Organoleptic Tests of The Addition of Telang Flower Extract (Clitoria ternatea) on Cow's Milk Yoghurt (Bos taurus) Production in Air Tawar Village, Langkat
Authors: Baubara Yusraini , Zahara Arini Shinta , Wardania Silvia
Published: July 2023

Yogurt is the oldest dairy product and is quite popular almost all over the world. Yogurt comes from pure cow's milk. Butterfly pea (Clitoria ternatea ) often referred to as butterfly pea or blue bean is a distinctive flower with a single petal in purple, blue, pink and white. Researchers wanted to see the effect of adding butterfly pea flower extract (Clitoria ternatea) to cow's milk yogurt (Bos taurus). This study employs a quantitative approach as its method. A quantitative approach was used to understand what the research subjects experienced from the color, taste, aroma and texture of the yogurt. The results of the study found that the addition of butterfly pea flower extract (Clitoria ternatea) at different levels had an effect on the organoleptic characteristics and texture of yogurt. The best practice produces organoleptic characteristics of taste (slightly sour), color (light blue), texture (slightly thick) and aroma (typical of yogurt).
La contingencia de una “segunda transición” en Chile. Reflejos, equivalencias y proyecciones desde el caso español
Authors: Castellanos López José Antonio
Published: July 2023

Los paralelismos y el establecimiento de similitudes entre los procesos de transición en Chile y España han ido cobrando una considerable fuerza en el seno de las ciencias sociales de un tiempo a esta parte. Las conexiones entre ambos procesos pueden establecerse también a nivel del léxico político y académico usado en los dos países. Basándose en documentación oficial y en el discurso público presente en la prensa y en los medios de difusión intelectual, el presente trabajo pretende analizar la utilización en Chile del concepto segunda transición, tomando como base para ello la elaboración de un marco comparativo con el caso español, que actuará siempre como un referente sobre el que plantear posibles conexiones, vínculos, contrastes o diferencias.
An Alternative Multiple Contracts Version of the SACRE
Authors: De Faro Clovis , Lachtermacher Gerson
Published: July 2023

Taking into consideration that the SACRE (system of increasing amortization in real terms), as originally instituted by Caixa Econômica Federal, is not financially consistent, an exact procedure, denoted as SACRE*, was proposed in de Faro and Lachtermacher (2022). An alternative version (SACRE-F) of this system was proposed by Forger (2010). The present paper submits a multiple contract version of SACRE-F. It is shown that, taking into due account the financial institution cost of capital, it is always better to implement the multiple contracts approach instead of the single contract option. An comparison between the both alternatives are detailed.
Pengaruh Dept to Equity Ratio (DER) dan Book Value per Share (BVS) terhadap Return Saham pada PT. Bisi Internasional, Tbk.
Authors: Purnama Ita , Suryadin Suryadin
Published: July 2023

This study aims to determine the effect of dept to equity ratio (DER) and book value per share (BVS) on stock return at PT. Bisi International, Tbk. The population in this study is financial statements that have been registered on the IDX from 2007 – 2020, namely 13 years, while the sample used is 10 years, namely from 2011 – 2020 where the sample determination uses purposive sampling, namely using certain criteria, one of which is the completeness of the report. finance. Data collection techniques use documentation and literature study while data analysis techniques use classic assumption tests, multiple linear regression tests, correlation and determination coefficients, t tests and F tests. the effect of book value per share and is significant on stock return, while simultaneously there is the influence of dept to equity and book value per share on stock return at PT. Bisi Internasional, Tbk.
Pengaruh Perceived Organizational Support (POS) dan Work Stress terhadap munculnya Perilaku Kontraproduktif dalam Perspektif Ekonomi Islam (Studi pada Karyawan PT. Gula Putih Mataram di Lampung Tengah)
Authors: Aziizah Salsabiila Nur , Zuliansyah Ahmad , Rosilawati Weny
Published: July 2023

The current business competition makes companies have to carry out a mature strategic plan. Mataram White Sugar Company is a company engaged in trade manufacturing. As for the background of this research, based on pre-research that has been done, it turns out that a number of employees experience work stress, this can be caused by the absence of bonuses given, or jobs that do not match their expertise. so that it shows the existence of deviant behavior carried out by employees in the company with various types such as: going home early and damaging the existing facilities at the company, leaving late, and working unprofessionally. The research method used in this study is a quantitative method. The population used in this research is all employees of PT. Mataram White Sugar, Central Lampung. The sample used in this research is the permanent employees of PT. Mataram White Sugar. The types of data used in this research are primary data and secondary data. Where the primary data obtained through distributing questionnaires. The questionnaire was distributed to employees via gform to 92 respondents using random sampling technique. The research results of perceived organizational support have no effect on counterproductive behavior and work stress has an effect on counterproductive behavior. In an Islamic economic perspective, it emphasizes that we as Muslims must always appreciate the contributions made by others. In addition, in Islam it has provided trials that the people themselves cannot possibly overcome, so that Islam prohibits people from despairing in carrying out activities and in Islam it is also forbidden to carry out behavior that can inhibit or harm other people.
Attitudes, Anxiety, Skills and Culture in Research: The Case of a Private Higher Education Institutions
Authors: Parilla Eric S , Dagani Arestday , Suguitan Ruby Ann
Published: July 2023

This study is about research attitudes, anxiety, skills and culture of private higher education institutions. Universities and colleges seek to cultivate and develop students. Their primary responsibilities are to provide quality education and substantially contribute to society. Moreover, the university should have a strong research culture to attain these goals. The study participants are full-time faculty members of the institution, and descriptive statistics and partial least squares are used to analyze data. The HEI under investigation showed a positive attitude towards research because the institution encourages its faculty members to do research activities. They also have moderate competence skills and are anxious about research activities.

 

On the other hand, the dominant research culture is constructive, and a supportive research environment characterizes it. According to the results of PLS-SEM, research skills are significantly related to research culture. Thus, the university should continuously upgrade its research skills to develop its research culture.
Direct Electrical Activation of the Shape Memory Effect
Authors: Schuh Christopher A. , Lai Alan
Published: July 2023

New research explores a zirconia-based shape memory ceramic that exhibits a unique type of electrically triggered martensitic transformation.
Fatigue Fracture of Nitinol
Authors: Malito Louis G. , Bowers Matthew L. , Briant Paul L. , Ganot Gabriel S. , James Brad
Published: July 2023

Nitinol fatigue fracture surfaces generally exhibit similar features to most engineering alloys, including a flat fracture plane, ratchet marks, radial lines, beachmarks, and striations.
Archaeometallurgical Study of an Ancient North-African Iron-Base Artifact
Authors: Salah Nihad Ben
Published: July 2023

A metallurgical study of a 10th century iron-base nail from the central-East coast of Tunisia reveals how early metallurgists without modern scientific knowledge created parts with engineered properties.
THE INFLUENCE OF PROBLEM BASED LEARNING AND MIND MAPPING MODELS ON LEARNING OUTCOMES INDONESIAN LANGUAGE STUDENTS OF CLASS X AT SMAN PAKUSARI
Authors: Aidah Chimayatul
Published: July 2023

Learning needs to be emphasized on process and quality to realize maximum learning outcomes. Learning Indonesian in class X is still not getting optimal results, so there is a need for a new model to be implemented, namely by using a problem based learning model and a mind mapping model. Learning with this observation report material is appropriate to use the problem based learning model because students are directly involved with what they see. Meanwhile, the concept map model makes it easier for students to design texts.The purpose of this study was to determine: (1) there is an effect of the Problem Basic Learning (PBL) Model on Indonesian Language Learning Outcomes for Class X Students at SMAN Pakusari Jember Regency, (2) there is an influence of the Mind Mapping Model (MM) on Language Learning Outcomes. Indonesia Class X Students at SMAN Pakusari Jember Regency, and (3) Is there an effect of the Problem Basic Learning (PBL) Model with the MIND MAPPING (MM) Model on the Indonesian Language Learning Outcomes of Class X Students at SMAN Pakusari Jember Regency. This quantitative research method is experimental. Due to the large population, the sub- population of the study was taken as many as 35 students. The school is SMA Negeri Pakusari class X 1 which uses 2 models, namely the Problem Basic Learning Model (PBL) and the Mind Mapping Model (MM). The data analysis technique in this study is to use two-way analysis. Based on the hypothesis test, it is proven that: (1) there is an effect of the Problem Based Learning model on the Indonesian Language Learning Outcomes of Class X Students on the LHO learning outcomes in the comparison of learning outcomes before and after treatment, the tcount value is 33.4356 with a significance value of 0.110. Because the value of tcount > ttable or the significance value is smaller than the 5% significance level. (2) There is an effect of the Mind Mapping model on Indonesian Language Learning Outcomes of Class X Students on learning outcomes in the comparison of Learning Outcomes before and after treatment, the tcount value is 32.569 with a significance value of .000 Because the tcount > ttable or the significance value is more smaller than the 5% level of significance. (3) There is an Influence of Problem Based Learning Model and Mind Mapping Model Together on Learning Outcomes for class X LHO in comparison of learning outcomes before and after treatment, the tcount value is 6.377 with a significance value of 0.206. Because the value of tcount > ttable or the significance value is smaller than the 5% significance level
Trend Komunikasi Politik di Media Sosial
Authors: Nurhidayat Ipan , Garis Regi Refian
Published: July 2023

Communication is an activity that cannot be separated from human life. Based on its form, there is interpersonal communication, small group communication, public communication, organizational communication and mass communication. Based on the context, there are several types of communication, such as business communication, health communication, intercultural communication, family communication and also political communication. Basically communication is a relationship between humans in order to achieve mutual understanding (mutual understanding). To explain about ganjar pranowo's political communication through Instagram social media, the author uses a descriptive method with a qualitative approach. With this method the researcher tries to describe, analyze, and build meaning about political communication in the current era. Ganjar Pranowo is a political figure who is very active on social media and often uses social media to communicate with his people. Ganjar Pranowo is well-known on social media for his accomplishments in advancing Central Java, and he also enjoys being involved in society both virtually and in person. The image of a politician must be effective and channeled to be effective. Social media is a popular media used and followed by many people. This has the potential to change public opinion in a number of ways. Ganjar Pranowo is a political figure who is very active on social media and often uses social media to communicate with his people.
The Empty Chair
Authors: Schwartz Susan
Published: July 2023

This research paper, focusing on psychology and drawing upon the works of Carl Jung and Andre Green, explores the concept of the “empty chair” as a symbol for emotional absence and the formation of an ‘as-if’ personality. It delves into the impact of early emotional wounds, particularly related to parental figures, on the development of this personality type. Through dreams and symbolic messages, the paper uncovers the potential for healing and transformation within the therapeutic process. It emphasizes the importance of emotional engagement in therapy and the role of the analyst in facilitating meaning-making and exploring unconscious fantasies. By revisiting emotional territories and navigating inner conflicts, individuals with an ‘as-if’ personality can move towards a more authentic and emotionally connected existence. This research paper sheds light on the origins, manifestations, and therapeutic possibilities for individuals with an ‘as-if’ personality, offering insights into personal growth and transformation.
A Simple Argument Proves the Riemann Hypothesis
Authors: Martila Dmitri
Published: July 2023

I have written a new proof of Riemann Hypothesis.
Pengaruh Lingkungan Kerja Fisik Terhadap Kinerja Pegawai PT. Beringin Jaya Kabupaten Simalungun
Authors: Siahaan Agus Ronaldo , Sulaiman Fahmi
Published: July 2023

Alasan dilakukannya penelitian ini adalah untuk memilih dan mengambil Tujuan dari PeneIitian ini adaIah untuk melihat bagaimana eIemen Iingkungan kerja fisik mempengaruhi kinerja pegawai di PT Beringin Jaya di Kabupaten Simalungun. Karena organisasi ini bergerak di bidang industri manufaktur, maka diasumsikan bahwa Iingkungan kerja fisik mempengaruhi kinerja pegawai. PeneIitian diIakukan selama tiga bulan dengan memberikan kuesioner PeneIitian kepada 30 responden. HasiI pengoIahan data menunjukkan signifikansi sebesar 0,0 yang lebih kecil dari 0,05, dan variabeI Iingkungan kerja fisik berpengaruh signifikan terhadap kinerja pegawai, hal ini menunjukkan bahwa faktor Iingkungan kerja fisik berpengaruh terhadap kinerja pegawai di antara beberapa faktor yang mendukung kinerja pegawai. The goal of this study was to see how physical work environment eIements affected employee performance at PT Beringin Jaya in Simalungun Regency. Because the organization is in the manufacturing industry, it is assumed that the physical work environment influences employee performance. The study was done over a three-month period by delivering research questionnaires to 30 respondents. The data processing results show a significance of 0.0, which is less than 0.05, and the physical work environment variable has a significant effect on employee performance, indicating that the physical work environment factor affects employee performance among several factors that support employee performance.
DIMENSIONAL PERILAKU KEPEMIMPINAN MELAYANI DALAM MENINGKATKAN KINERJA DI DALAM PERAN, DENGAN KETERLIBATAN KERJA SEBAGAI MEDIASI
Authors: Mulyaningrum Eka , Chrsta Ussup Riassy , Tunjang Hansly , Mahrita Ani
Published: July 2023

The objective of this study is to investigate the behavior of servant leadership (BSL) in enhancing in role performance. The role of work involvement was also examined as a mediator by the researchers. The study employed a survey methodology to collect data from 128 civil servants in Central Kalimantan. Out of the total respondents, 96 individuals willingly and accurately completed the questionnaire. The employed analytical approach utilises the hierarchical component model (HCM) and entails the examination of the second-order model that encompasses a dual-layered structure within the partial least squares structural equation modelling (PLS-SEM) framework to assess the proposed hypotheses. The results indicate that the manifestation of servant leadership behaviour, also known as BSL, has the potential to enhance one's performance within their designated role. Furthermore, the construct of job involvement (JI), assumes a significant function as a mediator in the examined associations. This study aims to investigate the various dimensions of servant leadership behaviour and its impact on role performance within government organisations in Indonesia. Additionally, the study seeks to explore the potential mediating role of work involvement in this relationship.
We need it: How Digital Marketing Tactics Influence the Purchasing Behaviour of Nigerian Millenials
Authors: Oyenuga Michael Oyedele  , Akhaine Mary Enose  , Omale Sunday Alewo
Published: July 2023

Businesses have come to the realization that customers of today especially the millenials are actively engaged over the internet and to give them place utility, they need to engage them digitally. The objective of this study was to determine the influence of selected digital marketing tactics and their influence on the purchasing behavior of Nigerian Millenials. Research was conducted using cross-sectional survey design with data collected using close ended questionnaires designed with 5-point Likert scale questions. The study’s population comprised active internet subscribers in FCT within the millennial age group, and a sample size of 400 was arrived at using Taro Yamani’s formula. Linear regression analysis was used to test all three hypotheses, and results showed that all two selected digital marketing tactics (social media marketing and search engine optimization) have positive influence on purchasing behavior of Nigerian Millenials. Thus, it was concluded that increased use of digital marketing tactics would positively affect the purchasing behavior of Nigerian Millenials.
Targeted mutagenesis and high-throughput screening of diversified gene and promoter libraries for isolating gain-of-function mutations
Authors: Huttanus Herbert M. , Triola Ellin-Kristina H. , Velasquez-Guzman Jeanette C. , Shin Sang-Min , Granja-Travez Rommel S. , Singh Anmoldeep , Dale Taraka , Jha Ramesh K.
Published: July 2023

Targeted mutagenesis of a promoter or gene is essential for attaining new functions in microbial and protein engineering efforts. In the burgeoning field of synthetic biology, heterologous genes are expressed in new host organisms. Similarly, natural or designed proteins are mutagenized at targeted positions and screened for gain-of-function mutations. Here, we describe methods to attain complete randomization or controlled mutations in promoters or genes. Combinatorial libraries of one hundred thousands to tens of millions of variants can be created using commercially synthesized oligonucleotides, simply by performing two rounds of polymerase chain reactions. With a suitably engineered reporter in a whole cell, these libraries can be screened rapidly by performing fluorescence-activated cell sorting (FACS). Within a few rounds of positive and negative sorting based on the response from the reporter, the library can rapidly converge to a few optimal or extremely rare variants with desired phenotypes. Library construction, transformation and sequence verification takes 6–9 days and requires only basic molecular biology lab experience. Screening the library by FACS takes 3–5 days and requires training for the specific cytometer used. Further steps after sorting, including colony picking, sequencing, verification, and characterization of individual clones may take longer, depending on number of clones and required experiments.
Effective service provision and partnerships in service providers for children and young people with special educational needs and disabilities: a mixed methods systematic review protocol
Authors: Tyldesley-Marshall Natalie , Parr Janette , Brown Anna , Chen Yen-Fu , Grove Amy
Published: July 2023

It is widely recognized that provision of services for children and young people (CYP) with Special Educational Needs and Disabilities (SEND) are enhanced when services such as healthcare, social care, and education collaborate and interact effectively, rather than separately. In the UK, while there have been significant changes to policy and provision which support and improve collaboration, professionals responsible for implementing these changes face multiple challenges, including a lack of specific implementation guidance and a logic model or framework to illustrate how effective multi-agency working could, or should, work. This systematic review aims to identify the ‘key ingredients’ for effective multi-agency working in services for CYP with SEND; and the most effective forms of partnership working in this setting. In addition, the review will highlight interventions that lead to improved service outcomes; and the conditions in the local area (organisational or geographical) that support and encourage success. This protocol has been written following the Preferred Reporting Items for Systematic Review and Meta-Analyses Protocols guidelines. Searches will be conducted on several health, care, education and applied social science databases from the year 2012 onwards. Citation chaining will be undertaken, as will broader grey literature searching to enrich the findings. Qualitative, quantitative, and mixed methods studies will be included, assessed independently and critically appraised or assessed for risk of bias using appropriate tools based on study design. Data will be extracted using a standardized, pre-piloted data extraction form. A convergent segregated approach to synthesis and integration will be used in which the quantitative and qualitative data will be synthesized independently, and then integrated using a joint display integration matrix. Results will be of interest to educators and health and social care professionals that provide services to those with SEND. These will also be used to develop policy recommendations for how UK healthcare, social care, and education services for CYP with SEND aged 0–25 can most effectively collaborate and improve service outcomes. The review will also identify any gaps in the literature to recommend areas for future research. Funding for this review was provided by the Department for Education.

PROSPERO registration: CRD42022352194.
Nomogram predicting overall survival after surgical resection for retroperitoneal leiomyosarcoma patients
Authors: Zhuang Aojia , Yue Xuetong , Tong Hanxing , Zhang Yong , He Fuchu , Lu Weiqi
Published: July 2023

Background

Surgery is the best way to cure the retroperitoneal leiomyosarcoma (RLMS), and there is currently no prediction model on RLMS after surgical resection. The objective of this study was to develop a nomogram to predict the overall survival (OS) of patients with RLMS after surgical resection.

Methods

Patients who underwent surgical resection from September 2010 to December 2020 were included. The nomogram was constructed based on the COX regression model, and the discrimination was assessed using the concordance index. The predicted OS and actual OS were evaluated with the assistance of calibration plots.

Results

118 patients were included. The median OS for all patients was 47.8 (95% confidence interval (CI), 35.9-59.7) months. Most tumor were completely resected (n=106, 89.8%). The proportions of French National Federation of Comprehensive Cancer Centres (FNCLCC) classification were equal as grade 1, grade 2, and grade 3 (31.4%, 30.5%, and 38.1%, respectively). The tumor diameter of 73.7% (n=85) patients was greater than 5 cm, the lesions of 23.7% (n=28) were multifocal, and 55.1% (n=65) patients had more than one organ resected. The OS nomogram was constructed based on the number of resected organs, tumor diameter, FNCLCC grade, and multifocal lesions. The concordance index of the nomogram was 0.779 (95% CI, 0.659-0.898), the predicted OS and actual OS were in good fitness in calibration curves.

Conclusion

The nomogram prediction model established in this study is helpful for postoperative consultation and the selection of patients for clinical trial enrollment.
Exploring the option of student-run free health clinics to support people living with type 2 diabetes mellitus: a scoping review
Authors: Kovanur Sampath Kesava , Ann-Rong Yan , Haggie Marrin , Tapara Timi , Brownie Sharon
Published: July 2023

Diabetes is a major cause of morbidity and premature mortality worldwide and now identified as a ‘public health emergency’ and a ‘modern and preventable pandemic’. Indigenous populations are disproportionately affected by type 2 diabetes mellitus (T2DM) and associated complications. Student run free clinics (SRFCs) may play an important role in the prevention and management of T2DM. The primary objective of this scoping review was to investigate the opportunity for curriculum enhancement through the role and effectiveness of SRFCs in managing T2DM. Electronic databases such as PubMed, CINAHL, Science Direct and Cochrane Library were searched from inception to October 2022. Identified records from database literature searches were imported into Covidence®. Two independent reviewers screened and extracted the data. The research team collectively created a data charting table/form to standardize data collection. A narrative synthesis was used to summarize the evidence. Six studies (total of 319 participants) that met our eligibility criteria were included in this scoping review. SRFCs can provide high-quality diabetic care, especially for uninsured and economically weaker population. Preliminary evidence further indicate that shared medical appointments and telehealth may facilitate diabetic care especially during times where access to care may be difficult (e.g., COVID lockdown). However, no study included in the review explored or discussed family centred/culturally sensitive interventions. Hence, such interventions should be made part of the curriculum in the future with students in SRFCs exposed to such an approach.
Associations between overweight, obesity, and mental health: a retrospective study among European adults aged 50+
Authors: Rindler Gregor Alexander , Gries Anna , Freidl Wolfgang
Published: July 2023

Background

The comorbidities associated with overweight and obesity have been well researched and scientifically proven while their relationship to mental health is still not verified.

Methods

This study is aimed at investigating reciprocal associations between obesity and mental health, and is intended to further analyze possible long-term effects using data from the Survey of Health, Ageing and Retirement in Europe (SHARE). In order to do that, waves 4 and 8, conducted in 2010 and 2019/20 of this survey, were analyzed in a cross-lagged panel approach including 16,184 adult Europeans (50+) using multiple linear regression analysis focusing on the Body Mass Index (BMI), depression status and quality of life (QoL).

Results

Findings yield significant cross-lagged effects in one direction regarding BMI predicting QoL and depression state, whereas depression state and QoL do not significantly predict BMI. Findings include people living with obesity, overweight, and underweight showing significantly decreased levels of QoL as well as increased depression scores compared to people of normal weight over a lag time of 10 years, where people living with obesity indicate the strongest effect.

Conclusions

However, results do not confirm reciprocal associations in the long term. Hence, there is a strong need to carry out further research on this issue.
Non-Covalent Bruton’s Tyrosine Kinase Inhibitors in the Treatment of Chronic Lymphocytic Leukemia
Authors: Montoya Skye , Thompson Meghan C.
Published: July 2023

Covalent Bruton’s tyrosine kinase inhibitors (cBTKi) have led to a paradigm shift in the treatment of chronic lymphocytic leukemia (CLL). These targeted oral therapies are administered as standard treatments in both the front-line and relapsed and/or refractory settings. Given their administration as a continuous therapy with a “treat-to-progression” strategy, limitations of their use include discontinuation due to toxicity or from progression of the disease. Non-covalent Bruton’s tyrosine kinase inhibitors (ncBTKi) distinguish themselves by binding reversibly to the BTK target, which may address the limitations of toxicity and acquired resistance seen with cBTKi. Several ncBTKis have been studied preclinically and in clinical trials, including pirtobrutinib and nemtabrutinib. Pirtobrutinib, which is now FDA approved for relapsed and/or refractory mantle cell lymphoma (MCL), has shown outstanding safety and preliminary efficacy in CLL in phase 1 and 2 clinical trials, with phase 3 trials underway. This agent may fill an unmet medical need for CLL patients requiring treatment after a cBTKi. Pirtobrutinib is particularly promising for the treatment of “double exposed” CLL, defined as CLL requiring treatment after both a cBTKi and venetoclax. Some patients have now developedacquired resistance to pirtobrutinib, and resistance mechanisms (including novel acquired mutations in BTK outside of the C481 position) have been recently described. Further study regarding the mechanisms of resistance to pirtobrutinib in patients without prior cBTKi exposure, as well as the potential for cross-resistance between cBTKi and ncBTKis, may be important to help inform where ncBTKis will ultimately fit in the treatment sequencing paradigm for CLL. An emerging clinical challenge is the treatment of CLL after ncBTKi discontinuation. Novel therapeutic strategies are being investigated to address the treatment of patients following disease progression on ncBTKis. Such strategies include novel agents (BTK degraders, bispecific antibody therapy, CAR T-cell therapy, PKC-beta inhibitors) as well as combination approaches incorporating a ncBTKi (e.g., pirtobrutinib and venetoclax) that may help overcome this acquired resistance.
A Novel Bispecific Antibody for EpCAM-Directed Inhibition of the CD73/Adenosine Immune Checkpoint in Ovarian Cancer
Authors: Ploeg Emily Maria , Britsch Isabel , van Wijngaarden Anne Paulien , Ke Xiurong , Hendriks Mark Alexander Johannes Martinus , Samplonius Douwe Freerk , Helfrich Wijnand
Published: July 2023

PD-1/PD-L1-inhibiting antibodies have shown disappointing efficacy in patients with refractory ovarian cancer (OC). Apparently, OC cells exploit nonoverlapping immunosuppressive mechanisms to evade the immune system. In this respect, the CD73-adenosine inhibitory immune checkpoint is of particular interest, as it rapidly converts pro-inflammatory ATP released from cancer cells to immunosuppressive adenosine (ADO). Moreover, cancer-cell-produced ADO is known to form a highly immunosuppressive extra-tumoral ‘halo’ that chronically inhibits the anticancer activity of various immune effector cells. Thus far, conventional CD73-blocking antibodies such as oleclumab show limited clinical efficacy, probably due to the fact that it indiscriminately binds to and blocks CD73 on a massive surplus of normal cells. To address this issue, we constructed a novel bispecific antibody (bsAb) CD73xEpCAM that inhibits CD73 expressed on the OC cell surface in an EpCAM-directed manner. Importantly, bsAb CD73xEpCAM showed potent capacity to inhibit the CD73 enzyme activity in an EpCAM-directed manner and restore the cytotoxic activity of ADO-suppressed anticancer T cells. Additionally, treatment with bsAb CD73xEpCAM potently inhibited the proliferative capacity of OC cells and enhanced their sensitivity to cisplatin, doxorubicin, 5FU, and ionizing radiation. BsAb CD73xEpCAM may be useful in the development of tumor-directed immunotherapeutic approaches to overcome the CD73-mediated immunosuppression in patients with refractory OC.
Self-Healing in Cyber–Physical Systems Using Machine Learning: A Critical Analysis of Theories and Tools
Authors: Johnphill Obinna , Sadiq Ali Safaa , Al-Obeidat Feras , Al-Khateeb Haider , Taheir Mohammed Adam , Kaiwartya Omprakash , Ali Mohammed
Published: July 2023

The rapid advancement of networking, computing, sensing, and control systems has introduced a wide range of cyber threats, including those from new devices deployed during the development of scenarios. With recent advancements in automobiles, medical devices, smart industrial systems, and other technologies, system failures resulting from external attacks or internal process malfunctions are increasingly common. Restoring the system’s stable state requires autonomous intervention through the self-healing process to maintain service quality. This paper, therefore, aims to analyse state of the art and identify where self-healing using machine learning can be applied to cyber–physical systems to enhance security and prevent failures within the system. The paper describes three key components of self-healing functionality in computer systems: anomaly detection, fault alert, and fault auto-remediation. The significance of these components is that self-healing functionality cannot be practical without considering all three. Understanding the self-healing theories that form the guiding principles for implementing these functionalities with real-life implications is crucial. There are strong indications that self-healing functionality in the cyber–physical system is an emerging area of research that holds great promise for the future of computing technology. It has the potential to provide seamless self-organising and self-restoration functionality to cyber–physical systems, leading to increased security of systems and improved user experience. For instance, a functional self-healing system implemented on a power grid will react autonomously when a threat or fault occurs, without requiring human intervention to restore power to communities and preserve critical services after power outages or defects. This paper presents the existing vulnerabilities, threats, and challenges and critically analyses the current self-healing theories and methods that use machine learning for cyber–physical systems.
Intermediate-Level Diet Quality of Brazilian Paralympic Athletes Based on National and International Indexes
Authors: Schneider Willian V. D. , Sasaki Carolina A. L. , da Costa Teresa H. M.
Published: July 2023

Diet quality indexes are used to characterize the dietary patterns of individuals and populations. The objective of this study was to compare two specific diet quality indexes, namely the Brazilian Healthy Eating Index Revised (BHEI-R) and the Global Diet Quality Score (GDQS), among Brazilian parathletes. This comparison was performed using either the initial 24 h recall (Rec1) or an assessment of usual dietary intake. Additionally, our study aimed to explore the association of these indexes with sociodemographic and behavioral sport variables. This cross-sectional, observational study evaluated 101 disabled athletes, including 23 international-level and 78 regional-/national-level participants, with a distribution of 82 males and 19 females across 13 Paralympic modalities. The Multiple Source Method (MSM) was employed, utilizing data from two or four non-consecutive 24 h food recalls. The comparison between the Rec1 and the assessment of usual dietary intake revealed the following median (IQR) values: for the BHEI-R, they were 60.3 ± 11.1 and 80.7 ± 6.2, respectively; for the GDQS, they were 19.5 ± 6.5 and 18.3 ± 2.6, respectively. Most athletes had diets classified as either “in need of modification” (according to BHEI-R) or of “moderate risk” (according to GDQS). The comparison between type of sport (team/individual), age, sex, income, education, sport scholarship, and nutritional support between the diet quality indexes is presented. Athletes involved in individual sports exhibited higher scores than team sports for BHEI-R (p < 0.02), and athletes receiving nutritional support achieved higher scores on both indexes (p < 0.03). The analysis of diet quality using the initial Rec1 with the BHEI-R was deemed sufficient to evaluate the diet quality of these athletes. However, when evaluating sporadically consumed food groups, the adoption of GDQS is necessary to assess usual dietary intake. We found that both BHEI-R and GDQS can be utilized to evaluate the diet quality of athletes with disabilities, and the diet quality of parathletes reached an intermediate score level.
Are Guideline Recommendations on Supportive Nutrition and Exercise Therapy for Cancer Patients Implemented in Clinical Routine? A National Survey with Real-Life Data
Authors: Hardt Luisa M. , Herrmann Hans J. , Reljic Dejan , Jaensch Peter , Zerth Jürgen , Neurath Markus F. , Zopf Yurdagül
Published: July 2023

Malnutrition and cancer cachexia are highly prevalent comorbidities of cancer, limiting patients’ quality of life and being relevant to prognosis. International and national clinical guidelines recommend supportive nutrition and exercise therapy for cancer patients. However, there is little current epidemiological evidence on the implementation of these guideline recommendations in clinical routine. To close this data gap, a national survey in Germany using an online questionnaire was conducted. There were 261 of a total of 5074 contacted hospitals and medical offices who participated in the survey (5.1% response rate). The data indicated that nutrition and exercise therapy for cancer patients is so far inadequately implemented, with 59% of the respondents reporting nutrition therapy as an integral part of oncological treatment, 66.7% having a nutrition specialist/team, and 65.1% routinely conducting a screening for nutritional status. Only half of the participants stated that there are defined goals in nutrition therapy. The majority of respondents (85.8%) generally recommend exercise therapy, but only a few of them provide specific offers at their own institution (19.6%) or at cooperation partners (31.7%). In order to implement the recommended combined nutrition and exercise therapy as part of regular care, there is a need for nationwide availability of multidisciplinary nutrition teams and targeted offers of individualized exercise therapy. Health policy support would be important to create the structural, financial, and staff conditions for appropriate guideline implementation in order to achieve the optimal treatment of cancer patients.