bluuebunny/crossref_metadata_2025 huggingface dataset:
THE IMPORTANCE OF REALISTIC SIMULATION LEARNING IN MANAGING RARE SITUATIONS IN ANESTHESIA: MALIGNANT HYPERTHERMIA
Authors:   Department of Anesthesiology and Intensive Care, Military Hospital Mohammed V, Faculty of Medicine and Pharmacy of Rabat, Mohammed V University, Rabat, Morocco., Youssef Aarjouni , Ibrahim Chikhi ,   Department of Anesthesiology and Intensive Care, Military Hospital Mohammed V, Faculty of Medicine and Pharmacy of Rabat, Mohammed V University, Rabat, Morocco., Ilyass Hmadate ,   Department of Anesthesiology and Intensive Care, Military Hospital Mohammed V, Faculty of Medicine and Pharmacy of Rabat, Mohammed V University, Rabat, Morocco., Mohamed Benani ,   Department of Anesthesiology and Intensive Care, Military Hospital Mohammed V, Faculty of Medicine and Pharmacy of Rabat, Mohammed V University, Rabat, Morocco., Walid Atmani ,   Department of Anesthesiology and Intensive Care, Military Hospital Mohammed V, Faculty of Medicine and Pharmacy of Rabat, Mohammed V University, Rabat, Morocco., Abdelhamid Jaafari ,   Department of Anesthesiology and Intensive Care, Military Hospital Mohammed V, Faculty of Medicine and Pharmacy of Rabat, Mohammed V University, Rabat, Morocco., Mustapha Bensghir ,   Head of the Anesthesia Department, Military Hospital Mohammed V, Faculty of Medicine and Pharmacy of Rabat, Mohammed V University, Rabat, Morocco.
Published: December 2024

Malignant hyperthermia (MH) is a rare, life-threatening pharmacogenetic disorder triggered by certain anesthetic agents, requiring rapid recognition and intervention to prevent serious complications. Given its infrequency, healthcare professionals, especially anesthesia providers, may have limited exposure to managing this critical emergency. This study aims to evaluate the impact of simulation-based training on improving the knowledge, skills, and confidence of anesthesia residents in managing malignant hyperthermia. A pre-experimental study was conducted with 50 anesthesia residents at the Mohamed V Military Instruction Hospital. Participants engaged in a simulation session designed to mimic the clinical scenario of malignant hyperthermia during surgery. Knowledge assessments conducted before and after the simulation revealed a significant improvement in the residentsÂ’ understanding of MH, including its recognition, triggers, and management. Self-reported confidence in handling MH crises also increased notably. Furthermore, 90% of residents expressed overall satisfaction with the simulation-based training, highlighting its value for enhancing critical care readiness. The results underscore the effectiveness of high-fidelity simulation in preparing anesthesia residents for rare but life-threatening scenarios, thereby contributing to better patient safety and clinical outcomes in anesthesia practice.
Health risk assessment using Monte-Carlo simulations due to arsenic contamination in groundwater in Punjab
Authors: Yadav Sangeeta , Kalkal Sunil
Published: December 2024

Groundwater contamination is a major environmental concern in many regions of India, including several districts of Punjab. In this study, a comparison is carried out between the deterministic and probabilistic approaches for calculating health hazard parameters due to arsenic contamination in groundwater in India. The probabilistic calculations are carried out through Monte-Carlo simulations to quantify the hazard index (HI) and carcinogenic risk. Sensitivity analysis is carried out to determine the contribution of input variables to the HI. From the deterministic and probabilistic approach, an HI greater than one is obtained in adults for all districts except Moga, whereas, for children, the HI is greater than 1 in all districts. This suggests a higher probability of risks, such as developmental problems and cardiovascular disorders. Excess lifetime carcinogenic risk, a measure of carcinogenic risk, is found above the US Environmental Protection Agency's recommended range of 1 × 10−6 to 1 × 10−4 in all districts. These values clearly indicate the long-term carcinogenic danger associated with arsenic exposure since they are far above the tolerable risk threshold of 1 × 10–4. Thus, necessary mitigation measures should be taken, and routine groundwater monitoring should be performed.
NEOCONSTITUCIONALISMO E CONSTITUCIONALISMO POPULAR
Authors: Urquhart de Cademartori Sérgio , Da Silva Barreto Júnior Williem
Published: December 2024

O debate em torno da legitimidade das deliberações democráticas tem se notabilizado por uma permanente tensão entre as perspectivas substancialistas, ligadas ao constitucionalismo jurídico, e as procedimentalistas, afeitas ao constitucionalismo político. Nesse contexto, o neoconstitucionalismo, de feição substancialista, e o constitucionalismo popular, de cariz procedimentalista, revelam-se duas poderosas ferramentas teóricas para se pensar o tema da legitimidade, razão pela qual o presente artigo propõe-se a analisar, de forma crítico-comparativa, similaridades e divergências que permeiam estas duas importantes tendências do constitucionalismo contemporâneo. Conclui-se que, enquanto o neoconstitucionalismo volta-se para o campo substancial, conferindo protagonismo aos tribunais para a resolução de conflitos, os adeptos do constitucionalismo popular consagram a efetiva participação dos cidadãos comuns nos processos decisórios, enfatizando a importância da regra majoritária.
INADEQUO-ME
Authors: Ribeiro Pók
Published: December 2024

Poiesis
GÊNERO E DESCONSTRUÇÃO DE ESTEREÓTIPOS DE NA CAMPANHA AVON PARA TODES
Authors: Nandi Formentin Claúdia , De Faveri Leacina Luiza
Published: December 2024

A publicidade tem tido um papel de fundamental importância no contexto social. Com ela e por ela, ganham pauta temas relevantes para as questões sociais do cotidiano. Ao mesmo tempo que a publicidade aponta para mudanças, essa forma de comunicação também reproduz relações sociais que não são mais condizentes com as demandas sociais contemporâneas. Nesse sentido, o estudo busca pesquisar sobre a “Desconstrução de estereótipos de gênero na campanha Avon para Todes”. A partir da pesquisa bibliográfica e qualitativa, objetiva entender: questões identitária; definição de gênero; o que são estereótipos e o que eles carregam diante da identidade de gênero; linguagem neutra; diversidade em campanhas de beleza, com foco na campanha “Avon para Todes”. Para fundamentar teoricamente esta pesquisa, traz as ideias de Hall (2003) para tratar de identidade e de Butler (2008) no que se refere à identidade de gênero. No que tange ao tema estereótipo, os autores com estudos-base para esta pesquisa foram Homi Bhabha (2007) e Correa e Mendes (2015). Como principais resultados alcançados aponta que a percepção de que a marca Avon buscou romper com certos padrões mercadológicos que, em uma perspectiva emancipatória, trata da superação do discurso que reproduz estereótipos na busca de uma publicidade comprometida com as demandas sociais.
INSURGÊNCIAS FEMININAS NA POESIA DE LÍNGUA PORTUGUESA A PARTIR DOS ANOS 1970
Authors: Flores Conceição , Ferreira Cavalcante Ilane
Published: December 2024

A partir da década de 1970, sobretudo, e no rastro da segunda onda do feminismo, emergiram nas literaturas de língua portuguesa obras marcantes que ousaram confrontar o cânone, revelando um modo poético de escrita marcadamente feminino. Este trabalho tem seu olhar para a poesia publicada em língua portuguesa e reflete sobre algumas das obras que representam não somente um marco, mas também uma ruptura e uma referência para as produções posteriores. Nesse recorte, o estudo busca uma poesia que representa o sujeito feminino a partir de temáticas consideradas tabus: o corpo, o erotismo, o desejo das mulheres. Assim, considera como marcos da insurgência poética as seguintes publicações: em 1971, em Portugal, Minha senhora de mim, de Maria Teresa Horta; e em 1976, no Brasil, Bagagem, de Adélia Prado. Já em relação aos países africanos de língua portuguesa, cuja independência ocorreu na sequência da Revolução dos Cravos (1974), toma como referência: em relação a São Tomé e Príncipe, a poesia de Alda do Espírito Santo, publicada em É nosso o solo sagrado da terra – Poesia de protesto e luta de 1978; no tocante a Moçambique, a poesia de Noémia de Sousa, publicada inicialmente em jornais e revistas, reunida em livro somente no século XXI; em relação a Angola, a poesia de Paula Tavares publicada em Ritos de passagem, em 1985.
MST, LUTA DE CLASSES E IDENTIDADE NACIONAL NA QUESTÃO AGRÁRIA
Authors: Tavares e Silva Tiago
Published: December 2024

O presente trabalho tem como maior objetivo analisar o Movimento dos Trabalhadores Rurais Sem Terra e sua relação com a reforma agrária a partir da ideia de nação. Na década de sua emergência, anos 1980, o nacionalismo brasileiro estava profundamente atrelado aos anseios por democracia e esta se constituiu em uma espécie de linguagem política do período que abarcava não apenas o MST, mas também setores conservadores da política brasileira. O MST desenvolve então uma forma de perceber sua função social diferente dos movimentos que o antecederam como as Ligas Camponesas, incorporando o elemento da nação como capital político para fortalecer sua práxis.
ENTREVISTA COM A ESCRITORA CONCEIÇÃO EVARISTO
Authors: Lima Duarte Constância
Published: December 2024

Conceição Evaristo, escritora mineira radicada no Rio de Janeiro, considerada pela crítica o nome mais expressivo da literatura brasileira contemporânea, é a nossa entrevistada. Conhecida militante e ativista do movimento negro, sua obra reflete intensamente as discriminações de raça, classe e gênero sofridas pelas pessoas negras, em especial as mulheres, ao mesmo tempo em que recupera a ancestralidade da negritude brasileira. Mestra pela PUC-Rio, com a dissertação “Literatura Negra: uma poética de nossa afrobrasilidade”, Conceição Evaristo é também doutora em Literatura Comparada pela Universidade Federal Fluminense, com a tese “Poemas malungos, cânticos irmãos”, em que estuda a poesia de Nei Lopes, Edimilson de Almeida Pereira e Agostinho Neto.
NEOLIBERALISMO E REFORMA DO ENSINO MÉDIO
Authors: Lúcio dos Santos Júnior Gentil , Bruno da Costa Santos Rafael
Published: December 2024

A recente reforma do ensino médio brasileiro reabriu o debate sobre o papel da escola na sociedade. Diante disso, este artigo busca entender como esse fenômeno se inscreve no contexto brasileiro. Mediante uma pesquisa bibliográfica, o estudo verificou que, para cada revolução nos modelos de produção, houve uma estrutura escolar correlata. É possível afirmar que houve uma reorganização do ambiente escolar para responder às demandas tanto do taylorismo-fordismo quanto do toyotismo. A recente reforma do ensino médio se inscreve nessa lógica, em meio a um forte programa de reestruturação produtiva, procurando readaptar os currículos escolares para fazer frente às demandas neoliberais de formação de mão de obra para um mercado de trabalho precarizado.
DESIGUALDADES SOCIAIS E COVID-19 NO BRASIL:
Authors: Forattini Fernando , Clarete Livia
Published: December 2024

Este artigo examina as narrativas das mídias sociais durante a pandemia de Covid-19 no Brasil, focando em narrativas socioeconômicas e raciais e na importância da comunicação precisa e confiável. Para isso, foram coletadas mais de 28,1 milhões de postagens no Facebook, Instagram e Twitter, entre 13 de março e 16 de outubro de 2020. Foi visto que essas narrativas refletiam interesses e perspectivas distintas da sociedade brasileira, enquanto algumas destacavam a responsabilidade individual na prevenção do vírus, outras enfatizavam a necessidade de políticas públicas para mitigar seus efeitos sobre as populações mais vulneráveis. Essas narrativas também estavam relacionadas a questões políticas e econômicas, refletindo disputas entre diferentes modelos político-econômicos. Representantes de um modelo neoliberal defenderam menor intervenção estatal e foram incapazes de lidar com os efeitos da pandemia, promovendo a desinformação e narrativas falsas visando a deslegitimação do impacto desigual da pandemia como resposta defensiva. Já os representantes de um modelo estatal mais participativo reconheciam a importância das medidas de prevenção e o reforço do sistema de saúde pública para combater a pandemia. Este estudo busca contribuir à compreensão das dinâmicas sociais e políticas em tempos de crise, mostrando como as narrativas presentes na arena pública, como as mídias sociais, foram usadas tanto como meio de ataque como de resistência ao desmonte do sistema de saúde, à desigualdade social exacerbada pela pandemia e como modo de disseminação de informações precisas para combater o vírus e a desinformação.
SUS COMO PATRIMÔNIO CULTURAL BRASILEIRO:
Authors: Fagundes de Souza Elizabethe Souza , Montechiari Renata
Published: December 2024

Este ensaio apresenta alguns elementos para justificar a importância do reconhecimento social do Sistema Único de Saúde na perspectiva de vir a ser patrimônio cultural. O estudo apresenta pontuações sobre sua trajetória e, particularmente, evidencia seu papel no enfrentamento da pandemia de covid-19 quando demonstrou grande capacidade de cuidar de pessoas e de salvar vidas, ganhando visibilidade positiva na sociedade e nas mídias. Recupera, na literatura, alguns aportes conceituais sobre patrimonialização a partir da Constituição Federal de 1988, que ampliou a noção de patrimônio ao abranger diversas tipologias, recortes temporais e sociais. Destaca a importância de desencadear o debate na sociedade para difundir e pleitear junto às instituições competentes o reconhe cimento e a preservação do Sistema Único de Saúde como patrimônio cultural brasileiro, articulando memória, história e conquistas sociais, com ênfase nos diferenciais culturais e políticos que permeiam a construção do sistema de saúde brasileiro. Por fim, apresenta algumas anotações que podem servir de trilha para compor o quadro de referências argumentativas que dê base a uma possível proposta de reconhecimento e preservação do Sistema Único de Saúde como patrimônio cultural brasileiro.
CAUSAS SUBJACENTES DA ESCALADA DAS TENSÕES SINO-ESTADUNIDENSES
Authors: Seron Miyakawa Seiji , Ribeiro Jansen Ferreira Mariana
Published: December 2024

O presente artigo visa salientar algumas das causas do acirramento crescente das tensões entre EUA e China nos últimos anos. A restauração do capitalismo na China foi essencial para a superação da crise capitalista internacional da década de 1970, possibilitada pela transferência de boa parte da atividade manufatureira situada, até então, nos países centrais para a Ásia. Até 2008, o crescimento econômico mundial foi motorizado pelas exportações manufatureiras asiáticas – chinesas, sobretudo – para os EUA, e pela sustentação dos déficits comerciais estadunidenses por meio da aquisição de títulos do Tesouro deste país pelas economias comercialmente superavitárias. A forte retração do comércio mundial que se seguiu ao estouro da bolha imobiliária estadunidense açodou a transição da China a um novo padrão de acumulação, cujo dinamismo provenha mais do consumo das famílias e da inovação autóctone do que das exportações e dos investimentos, além de ocasionar uma drástica expansão das exportações de capital chinesas. Este aumento da internacionalização do capital, e também das capacidades tecnológicas da China, contrasta com a baixa produtividade da economia chinesa e com outras vulnerabilidades que o país ainda sofre nos âmbitos financeiro, militar e até cultural e ideológico. Assim, a China ainda não é capaz de contestar a hegemonia estadunidense, embora já se equipare aos EUA e a outras potências mundiais em vários aspectos parciais.
APRESENTAÇÃO
Authors: De Paula Barbieri André Augusto
Published: December 2024

APRESENTAÇÃO
O TRABALHO DOS ENTREGADORES POR APLICATIVOS DIGITAIS NA PRODUÇÃO CIENTÍFICA DO NORDESTE
Authors: Guedes Ladosky Mario Henrique , Pereira Couto Marcia de Lima , Lima Teixeira Luiza Dantas de Souza
Published: December 2024

Os estudos sobre trabalho têm se dedicado cada vez mais a compreender a atividade de entregadores por meio dos aplicativos digitais. É crescente a presença de resultados de pesquisa em congressos acadêmicos nacionais e internacionais, em artigos para revistas científicas, em monografias de conclusão de curso de graduação, teses e dissertações em diversos Programas de Pós-graduação. Dentro dessa ampla gama, este artigo traz breves considerações, com recorte na produção bibliográfica dos Programas de Pós-graduação e de cursos de graduação levantadas no acervo da Biblioteca Digital de Teses e Dissertações (BDTD) de Universidades no Nordeste, e artigos encontrados no Portal de periódico da CAPES e na base do Google Acadêmico. Interessa-nos compreender qual o perfil de tais estudos sobre entregadores por meio das publicações: quais as áreas de conhecimento que têm se ocupado de investigar o trabalho de entregadores? Desde quando os entregadores se tornaram tema de interesse científico? Quais métodos e/ou técnicas de pesquisa têm sido utilizados? Qual o foco principal de questões abordadas? Em que medida os aportes teóricos-conceituais sobre o modo de produção capitalista têm sido utilizados nas publicações sobre os entregadores no Nordeste? Estas são algumas questões que este artigo trata. Antes de entrar nelas, dedicamos uma primeira seção a reflexões sobre a articulação do capitalismo de plataforma com formas de superexploração da força de trabalho no Nordeste, de modo a ter um “pano de fundo” com o qual as pesquisas sobre entregadores nesta região têm que lidar. Considerações finais sintetizam as reflexões do texto.
TRABALHO NOS CLÁSSICOS DA SOCIOLOGIA
Authors: Barbosa Guilherme Ryan
Published: December 2024

Resenha do livro
SANSON, Cesar. O trabalho nos clássicos da sociologia: Marx, Durkheim e Weber. São Paulo: Expressão Popular; Natal: EDUFRN, 2021. 221 p.
CRÍTICA AL MONTAJE CAPITALISTA, COLONIAL, PATRIARCAL
Authors: Expósito Julia , Sacchi Emiliano
Published: December 2024

En este trabajo nos proponemos indagar de modo crítico la relación entre capitalismo, patriarcado, colonialidad. Estas tres dimensiones se constituyen mutuamente y sin jerarquías, formando un montaje en el que cada una sostiene a la otra. El capitalismo, la colonialidad y el patriarcado nacieron el mismo día y bajo una relación de mutua presuposición. Es decir, las respectivas formas de organización de la experiencia en términos de clase, raza, sexo, género, no son realidades distintas que existan aisladas entre sí y cuya articulación solo sea posible a posteriori. Para plantear estas cuestiones vamos a encarar nuestro trabajo desde dos perspectivas. Por un lado desde una crítica decolonial que ha trabajado, sobre todo, en la vinculación entre capitalismo y colonialidad. Por otro, desde una crítica feminista que ha trabajado en la relación entre capitalismo y patriarcado. Siguiendo estos desarrollos, reconociendo sus potencialidades y sus límites, pretendemos lograr algunas estrategias para comprender el triedro capitalista colonial patriarcal, la figura que componen, la fuerza de sus relaciones y sus líneas de fractura.
HETEROSEXUALIDAD COMO CONDICIÓN SINE QUA NON
Authors: Prado Carli
Published: December 2024

Hablar de “la heterosexualidad” de forma anacrónica resulta, sin duda, problemático, tal como demuestra Katz en La invención de la heterosexualidad. Ahora bien, si bien el uso del concepto “heterosexualidad” como descriptor vincular consolidado en relación al pasado es desacertado, existe una preocupación por nombrar las prácticas que, aun antes de esta formulación médico-jurídica, ya eran fuertemente controladas (y hasta eliminadas, física y discursivamente) y que, a su vez, funcionaron como parte fundamental en la consolidación del ego conquiro capitalista. En este sentido, más que advertir el corte entre los discursos sobre la sodomía y la homosexualidad, este trabajo se propone dar un primer paso en la recomposición de sus relaciones en función de pensar no una heterosexualidad ahistórica, sino un régimen de diferencias sexo-genérica (y raciales) que aún sobrevive en nuestros imaginarios poscoloniales. En este sentido, en tanto introducción, este trabajo retomará una Arqueología del mestizaje (Catelli, 2020) a la par de reconstruir el argumento en La invención de la heterosexualidad (Katz, 2011) para desarrollar la problemática antes mencionada.
WALTER BENJAMIN E A DECOLONIALIDADE
Authors: Mülbersted Pereira Pedro , Paim Elison Antonio
Published: December 2024

O artigo propõe um debate sobre a possibilidade de estabelecer uma relação dialógica entre o ideário de Walter Benjamin e a perspectiva decolonial. Para isso, analisamos o pensamento de Benjamin a partir de alguns de seus interlocutores, bem como a decolonialidade a partir de autores vinculados a esta perspectiva. Ambos têm como ponto em comum a crítica à Modernidade: debatemos se estas críticas se aproximam ou são incompatíveis; se a crítica benjaminiana pode estender-se para além da Europa; como as experiências coloniais europeias estão presentes na maneira como Benjamin pensa a cultura e a História; e, por fim, se a categoria benjaminiana dos vencidos da História comporta o conceito de condenados da terra de Fanon. Apontamos que o pensamento de Benjamin, por mais singular e original que seja, parte de uma epistemologia eurocentrada, construída a partir da retórica da modernidade, e insere-se dentro do cânone ocidental; contudo possui brechas por onde a decolonialidade pode ser infiltrada para potencializar a sua crítica e, assim, construir algo novo, um pensamento de fronteira.
NÃO SEI - TRILOGIA DO SILÊNCIO E DA DÚVIDA
Authors: Miguel Marcelo Calderari
Published: December 2024

Poiesis.
Eficiência e demanda nutricional de cultivares de melão em função de doses de fósforo
Authors:   , Sousa Valdívia de Fátima Lima de
Published: December 2024

A cultura do melão apresenta uma alta demanda por nutrientes sendo o fósforo (P) o que mais limita a produção. Devido a grande maioria dos solos brasileiros apresentarem elevada capacidade de retenção de P, se faz necessário a aplicação de elevadas doses de fosfatos. Assim, tem-se intensificado a busca para o aproveitamento do potencial adaptativo de genótipos as
condições adversas de fertilidade do solo, buscando cultivares que apresentem maiores eficiência nutricional. Com o objetivo de avaliar a eficiência e a demanda nutricional quanto ao uso de fósforo em cultivares de melão em diferentes doses de fósforo dois experimentos foram realizados no período de outubro a dezembro de 2015 (Experimento 1) e de agosto a novembro de 2016 (Experimento 2). Nos dois experimentos o delineamento experimental foi em blocos casualizados
completos e os tratamentos foram distribuídos em parcelas subdivididas com cinco repetições. Nas parcelas foram dispostos as três doses de fósforo (0, 105 e 210 kg ha-1, respectivamente, que corresponde a 0, 50 e 100% da quantidade de P2O5 utilizado na região para melão) e nas subparcelas as dez cultivares de melão, para o experimento 1 e 8 genótipos, no experimento 2. Foram avaliadas
as seguintes características: Produtividade, Peso médio de fruto, número de frutos por planta, teor foliar de fósforo, demanda de nutrientes e os índices de eficiência agronômica, fisiológica, recuperação e de utilização. Os resultados encontrados mostram que os genótipos de melão apresentaram comportamento diferenciado com relação à eficiência de utilização de P; Os genótipos responderam de forma significativa ao aumento do nível de fósforo no solo, com incrementos no número de frutos por planta, peso médio de fruto e produtividade; Dentre os genótipos avaliados o acesso A50 foi eficiente e responsivo, podendo ser indicado para aumentar a eficiência no uso de P por meio de cruzamentos com cultivares ou linhagens melhoradas; Os maiores acúmulos de NPK foram observados no genótipo A50
Daidzein Inhibits Non-small Cell Lung Cancer Growth by Pyroptosis
Authors: Zeng Fanfan , Zhang Yu , Luo Ting , Wang Chengman , Fu Denggang , Wang Xin
Published: December 2024

Introduction:

Non-small cell lung cancer (NSCLC) represents the leading cause of cancer deaths in
the world. We previously found that daidzein, one of the key bioactivators in soy isoflavone, can inhibit
NSCLC cell proliferation and migration, while the molecular mechanisms of daidzein in NSCLC remain unclear.

Methods:

We developed an NSCLC nude mouse model using H1299 cells and treated the mice with daidzein
(30 mg/kg/day). Mass spectrometry analysis of tumor tissues from daidzein-treated mice identified 601 differentially
expressed proteins (DEPs) compared to the vehicle-treated group. Gene enrichment analysis revealed
that these DEPs were primarily associated with immune regulatory functions, including B cell receptor and
chemokine pathways, as well as natural killer cell-mediated cytotoxicity. Notably, the NOD-like receptor signaling
pathway, which is closely linked to pyroptosis, was significantly enriched.

Results:

Further analysis of key pyroptosis-related molecules, such as ASC, CASP1, GSDMD, and IL-1β, revealed
differential expression in NSCLC versus normal tissues. High levels of ASC and CASP1 were associated
with a favorable prognosis in NSCLC, suggesting that they may be critical effectors of daidzein's action.
In NSCLC-bearing mice treated with daidzein, RT-qPCR and Western blot analyses showed elevated mRNA
and protein levels of ASC, CASP1, and IL-1β but not GSDMD, which was consistent with the proteomic data.

Conclusion:

In summary, this study demonstrated that daidzein inhibits NSCLC growth by inducing pyroptosis.
Key pathway modulators ASC, CASP1, and IL-1β were identified as primary targets of daidzein. These
findings offer insights into the molecular mechanisms underlying the anti-NSCLC effects of daidzein and
could offer dietary recommendations for managing NSCLC.
Nitroheterocyclics as Anti-Tuberculosis Agents: An Overview
Authors: De Suparna S. , Gupta Shweta D. , Degani Mariam S.
Published: December 2024

Nitroheterocyclics have been used for treating infections since the beginning
of the 20th century, however, because of their potential toxicities, they have not been
exploited thoroughly, except for a few well known drugs like metronidazole. With the
growing threat of multidrug resistant tuberculosis in the last two decades, and
interesting preliminary results obtained for nitro heterocyclics, their potential as
antituberculosis agents has been realised relatively recently.
Thus, after a gap of several decades, nitroheterocyclics are in the forefront amongst the
newer scaffolds that have shown utility in treating TB, with five molecules containing
the nitro functionality in various phases of clinical trials as well as therapeutic use.
Interestingly, these compounds act by multiple different mechanisms of action, and this
aspect can be explored further for designing newer molecules.
This review presents a detailed discussion of chemical properties of nitro compounds,
the importance of which is highlighted in their mechanisms of action as well as
toxicity. This is followed by their classification according to the heterocyclic structures,
leading to an understanding of mechanisms of action, structure activity relationship and
toxicity. Thus, this review about the current status of nitro containing compounds as
anti-TB agents could aid in the design of newer molecules containing
nitroheterocyclics in the scaffolds, and maintain optimum balance between anti-TB
potency and potential toxicity.
Role of HR Analytics in People Management: Challenges and Opportunities in the Indian IT/ITeS Space
Authors: M. Freeda Maria Swarna , Khan Shaheed , Ramalingam Panch , P. Amarnatha Reddy
Published: December 2024

Human capability and capacity are what determine what an organization can
do, and thence, managing human resources (HR), or human capital, is one of the most
important, if not significant, functions of an organization. Considering the size of the
organization, and in a day and age where organizations have thousands of employees
that are spread across a wide geographical area, HR analytics comes into play. HR
analytics, in a true sense, provides the necessary scientific support to decision-making
and process improvement concerning a firm/organization’s HR and the organization in
general. The way organizations are growing, and the dynamic role that the HR
ecosystem plays makes it pertinent that a robust HR analytics system is in place. With
more organizations realizing that qualitative data helps to hire, engage, and retain the
right talent, the investment in HR analytics has seen an increase. It is right to say that
HR analytics aims to provide insights into how best to manage employees and reach
business goals. Because of data availability, it is important for HR teams to identify
data relevance and its usage, leading to maximizing return on investment (RoI). The
chapter places a perspective on how HR is i) identifying high-performing applicants, ii)
supportingthe analysis of pertinent aspects of engagement, iii) identifying high-value
career paths and leadership applicants, iv) analyzing strengths of prospective and
existing associates, v) ushering in a qualitative and metric oriented performance
management system (PMS), and vi) managing/predicting attrition.
Impact of HR Analytics on Organizational Performance: A Modern Approach in HR
Authors: Srivastava Nidhi , Bhardwaj Isha
Published: December 2024

The field of human resource analytics, characterized by its emphasis on
data-driven and analytical approaches within human resources management, is rapidly
emerging as a critical element in organizational contexts. Our work environments are
evolving due to the swift integration of data and information processing advancements
with the progress of human resources management (HRM). This paper explores the
existing body of research on HR analytics and its significance in making predictive
decisions within organizations. HRM is centered on identifying tools and metrics,
founded on the fundamental principle that employers and employees can collaborate to
achieve shared objectives within the hierarchical structure of an organization. In such a
dynamic landscape, human resources remain a pivotal distinguishing factor for any
organization, presenting opportunities for competitive growth and the creation of
essential organizational value.
Predicting Employee Performance Using Predictive Models
Authors: V. Sasirekha , P. Gomuprakash , R. Suresh
Published: December 2024

An employee performance forecasting overview typically outlines the key
components and objectives of a forecasting model developed to assess employee
effectiveness in the workplace. Such models include employee demographics, jobrelated factors (job description, tenure, etc.), performance metrics (sales figures,
customer feedback, etc.), and psychometric scores (personality traits, cognitive
abilities). The goal of such models is to identify the factors most strongly associated
with high performance and use this information to predict future employee success.
This chapter describes potential challenges and limitations associated with the
predictive models, such as ethical concerns about the use of personal data, the potential
for bias or error in predictive algorithms, and the need to balance the benefits of
predictive modeling with concerns about employee privacy and autonomy.
A Numbers Game or a People Game: An Analytical Approach to Bring the Best Talent to the Organizations
Authors: Rathee Rupa , Lamba Madhvi
Published: December 2024

Human resources analytics (HR analytics) is an interesting field of study for
those who love to play with numbers. Playing with numbers seems fun, but the
quantified data helps organizations in many ways. Do you want to go a long way in
your business? Then, yes! HR analytics is for you. HR analytics deals with interpreting
data by applying statistical tools in order to get meaningful information so that
predictive analysis for the growth of an organization can be done. The modern concept
of HR is more data-driven, and HR analytics provide an opportunity for organizations
to follow data-driven approach in order to manage people. HR analytics can be applied
to numerous functions of HR, but this chapter will specifically cover the concept of HR
analytics by emphasizing more on talent management analytics and its aspects. Are you
looking for the best talent in the market? Do you want to get qualitative people in
minimum costs and time? Then, this chapter will help you by elaborating on numerous
recruitment metrics and suggesting how talent management analytics can help in
managing people and enhancing an organization’s profitability. Moreover, this chapter
also provides theoretical and practical insights to the readers to enhance their
understanding with the help of numerical interpretations.
Exploring Differences In-house Human Resource Versus Outsourced Human Resource Small Business Employee Samples in Perceived Organizational Support
Authors: Carter Precious , Blau Gary , Deckop John
Published: December 2024

No prior research has focused on comparing in-house human resource (HRI) versus outsourced human resource (HRO) small organization employee samples on perceived organizational support (POS). Using a survey methodology, the sample sizes of 101 HRI United States (US) employees and ninety-seven HRO US employees were equivalent in terms of company size, company age, gender, years of work experience, work schedule, average HR response time, and POS. Comparisons between HRI versus HRO samples for specific type of organizational support on POS showed that the HRI employee sample perceived higher POS for the Personalized and Collectivist than Monistic type. No differences were found for the HRO sample. In addition, a significant difference in correlations was found between HRI versus HRO employees’ average HR response time for resolving an issue to POS, with the relationship more negative for the HRI sample. Collectively these results suggest that HRI employees were more sensitive to the type of perceived organization support, and a slower HR response time negatively affected their POS. Study limitations and future research issues are discussed.
Impact of Point-of-Care Laboratory Diagnostics on Emergency Department Processing Times During the COVID-19 Pandemic
Authors: Kureljak Dunja , Šimić Ševerdija Lidija , Krapić Mia , Marinović Iva , Lerga Mate , Juranić Lisnić Vanda , Pavletić Martina
Published: December 2024

Aim: In 2020 Emergency department (ED) in the Clinical hospital centre Rijeka established Point-of-care polymerase chain reaction (POC-PCR) testing for Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In addition to suspect cases, the ED also regularly tested hospital employees. To reduce the number of samples, employee’s swab samples were pooled for testing. This study aimed to analyse the impact of POC-PCR on diagnostic samples’ processing times, evaluated the efficacy of the pooling method among hospital personnel, and determined percentage of false-negative rapid antigen tests (RATs) in comparison with POC-PCR. Materials and Methods: The study included ED patients, hospitalized patients, and hospital personnel. Patients underwent oropharyngeal and nasopharyngeal swabbing. Personnel were screened using the pooling method, combining up to five swabs per test tube. Real time PCR (RT-PCR) was modified to POC-PCR, with or without automated nucleic acid extraction. High-priority patients were tested using the Multiplex PCR QIAstat-Dx Respiratory SARS-CoV-2 Panel. Results: Before the POC-PCR laboratory was established, the median processing times from sample collection to PCR results were 74.29 and 8.35 hours, respectively. Following the establishment of the POC-PCR laboratory in 2021, the median further reduced to 3.25 hours in September 2021, 2.30 hours in September 2022, and eventually reached 1.30 hours in September 2023. Additionally, out of the total 1608 RATs conducted over a 3-month period, 3.4% were false negatives. The pooling method allowed hospital staff samples to be analysed within 2.30 hours, or in the case of a positive pool, within 6 hours of each shift. Multiplex PCR for severe ED patients showed predominant SARS-CoV-2, followed by Rhinovirus/Enterovirus, Influenza, and other Coronaviruses. Conclusion: POC-PCR integration in the ED has significantly reduced time to diagnoses and proved the efficacy of the pooling method, easing the burden on ED and paving the way for further POC-PCR laboratory development.
Recommendation for Management of Deep Vein Thrombosis in the Emergency Medicine
Authors: Rošić Damir , Radaković Ivan , Kinkela Fran , Premužić Meštrović Ivica , Lulić Davorka , Keranović Adis
Published: December 2024

Duboka venska tromboza je multifaktorska bolest u koje dolazi do nastanka tromba u dubokim venama. Važno je njezino rano prepoznavanje i liječenje jer može uzrokovati plućnu emboliju te najopasniju komplikaciju, smrtni ishod. Cilj je ovih smjernica standardiziran pristup bolesniku u hitnoj medicinskoj službi, koji će omogućiti brzo i točno postavljanje dijagnoze i pravovremeno liječenje u bolničkim ili kućnim uvjetima. U dijagnostičkom smislu, najprije je važno procijeniti kliničku vjerojatnost pomoću Wellsova skora, potom odrediti D-dimere i, ako je potrebno, prema postupniku učiniti kolor-dopler. Osnovu liječenja duboke venske tromboze predstavlja antikoagulantna terapija, čime sprječavamo progresiju tromba i potencijalnu embolizaciju, a samim time i ozbiljne životno ugrožavajuće komplikacije.
Iron-chelating agent alleviates chronic hydrocephalus in an experimental model of subarachnoid hemorrhage
Authors: Havryliv T. , Smolanka V. , Smolanka A. , Chaulagain Deepak , Devinyak O. , Petrikonis Kestutis , Balnytė Ingrida
Published: December 2024

Background. The iron-chelating agent is being tested in this research to see whether or not it may aid rats with experimental communicating hydrocephalus caused by an intraventricular blood clot. Subarachnoid hemorrhage (SAH) causes chronic post-hemorrhagic hydrocephalus (CPHH) in one-third of patients, and up to 45 % of patients require permanent cerebrospinal fluid diversion during follow-up, with about 50 % shunt failures within a year. Hemoglobin degradation products induce subarachnoid fibrosis and consequent hydrocephalus, with iron as a critical factor. Iron-chelating agents reduce iron overload after SAH. ­Materials and methods. Our study used Wistar rats weighing 250–500 g. The first group (the controls) was without surgery. In the sham group, 0.15 ml of normal saline was administered into the cisterna magna, followed by a second injection 48 hours later. A 0.15 ml blood injection into cisterna magna was followed by a 0.15 ml blood injection 48 hours later, which was performed in the third treatment group, a blood group minus minocycline (BGMM). The fourth double hemorrhagic group (blood group plus minocycline — BGPM) received iron-chelating agent — minocycline. Transcranial ultrasonography was used in all groups, assessing the Levene index (LI) in the rats before and after surgery. CPHH was defined as a ventricular index above the 97th percentile of the pre-intervention LI (1.297). Morphological signs of SAH (blood in subarachnoid space and ventricular wall damage) were evaluated histologically. Results. Ninety-seven operations were done in 50 rats with a 15% posthemorrhagic postoperative mortality. Hydrocephalus in the BGMM group occurred in 56 % of rats, according to the ultrasonography, and all had SAH features with ependymal integrity disruption, according to histological investigations. The introduction of minocycline in the BGPM group prevented an increase in LI after autologous blood injection (similar values of preoperative mean LI = 1.079 ± 0.096 and postoperative mean LI = 1.034 ± 0.058). The difference between BGMM and BGPM groups was highly significant, with a mean of 0.179 ± 0.029, t(41) = 6.12, p < 0.00001. Conclusions. Based on the findings, minocycline alleviates ventriculomegaly in rats. The data suggests that iron-chelating agents may be utilized to treat and prevent CPHH. By illustrating vascular disorders, the technology may become more valuable.
The Influence of Climate Factors on the Incidence Area of Fusarium spp. in Shallots on Java Island during the Triple-Dip La Niña (2020-2022)
Authors: Dharma Krisnanda Surya
Published: December 2024

Shallots are a strategic horticultural commodity that contributes to inflation in Indonesia. The productivity of shallots is vulnerable to pests and diseases. Based on the incidence area during the La Niña period (2020 – 2022), Fusarium spp. is among the top five main pests and diseases reported to attack shallot crops in Java. Climate factors are suspected to have an effect on diseases incidence in the field. So far, there has been no research on the influence of climate factors on Fusarium twisted disease in Java. This study aims to analyze the influence of climate factors on the monthly incidence area of Fusarium spp. in Java during the La Niña period (2020 – 2022). The analysis used correlation and simple linear regression tests. Based on the correlation test, humidity and precipitation had a strong positive correlation with the incidence area of Fusarium spp. in shallots. Conversely, the sunshine duration had a strong negative correlation, while the temperature showed no correlation. From the simple linear regression test, humidity, precipitation and sunshine duration was found to strongly influence Fusarium spp. incidence, accounting for 47%, 48% and 40%, respectively (p<0.05). Temperature had no effect because it had the lowest fluctuation among other climate factors, ranging between 26 - 27.5°C, which was ideal for the development of Fusarium spp. To manage Fusarium spp. on shallots, it is recommended to select resistant varieties, optimize plant spacing, use fertilizers judiciously, and utilize healthy seeds. Additionally, the application of biological agents can suppress the growth of pathogenic fungi and increase plant resistance.
Kesepakatan ASEAN dalam Menangani Kebakaran Hutan dan Lahan Indonesia, 1990-2015
Authors: Hamdani Muhammad Fachrizal , Rohmawati Yulia , Nurhidayati Reni Putri
Published: December 2024

Indonesia is a country that experiences many cases of forest and land fires, so this has triggered ASEAN to take the initiative to resolve the problem through two agreements, namely the 1997 Regional Haze Action Plan (RHAP) and the ASEAN Agreement on Transboundary Haze Pollution (AATHP) which was ratified by all ASEAN members. 2014. Therefore, this research focuses on Malaysia's and Singapore's responses to Indonesia in handling Indonesia's forest and land fire cases through the RHAP and AATHP from 1990 to 2015, as well as the impact of these two ASEAN policies on Indonesia in addressing forest and land fires. This research method is a historical research method using laws, written regulations, newspapers, articles, and books as research sources. The research results indicate that Malaysia's and Singapore's responses to Indonesia within the RHAP framework were effective because each country had its own focused tasks. Indonesia experienced positive impacts from the RHAP policy because the three countries took direct actions in addressing forest and land fires in Indonesia. Conversely, Malaysia's and Singapore's responses to Indonesia within the AATHP framework were less effective due to their persistent pressure on Indonesia to ratify the AATHP quickly. Indonesia experienced more negative impacts from the AATHP policy because it received a negative image from Malaysia and Singapore due to the prolonged AATHP ratification process.
РАЗРАБОТКА И МОДЕЛИРОВАНИЕ СВЧ-ФИЛЬТРА С КОНТАКТАМИ ТИПА FLIP-CHIP
Authors: Сковородников С. , Семенов Д.
Published: December 2024

В рамках совместной работы по проектированию и организации
серийного производства полосно-пропускающего фильтра Х-диапазона
специалистами ООО «СДС Электроникс» была выполнена разработка
СВЧ-фильтра с контактами типа flip-chip. В статье представлены
результаты моделирования СВЧ полосно-пропускающего фильтра
с использованием отечественной САПР «Гамма» и сравнение
их с параметрами, измеренными на серийных образцах. Исследована
возможность оценки диэлектрической проницаемости материалов,
применяемых для изготовления СВЧ-фильтров.
STUDENTS’ UNDERSTANDING OF WORKPLACE DIVERSITY: THE CASE OF REPUBLIC OF NORTH MACEDONIA
Authors: Bozhinovska Tihona , Etimov Ljupcho
Published: December 2024

The importance of the research on workplace diversity has significantly increased in the past few decades. Namely, as a result of the increased possibilities for working from distance and the changes in the regulations that protect the rights of the individuals and groups with different background and physical and psychological characteristics, the workplace diversity and inclusion issues become a prominent research topic in the human resource management and management literature.  Therefore, the aim of this study is to investigate students’ understanding of diversity in our country, on a sample of students from the Faculty of Economics – Skopje. The need for conducting such a study in our country emanated from the fact that we live in a society where diversity issues are perceived and acknowledged. For investigating students’ understanding of diversity, we used two instruments (Reaction-to-Diversity Inventory and Workplace Diversity Survey) developed by De Meuse and Hostager (2001). The first one was used for investigating students understanding of the term workplace diversity and the second one for researching the determinants of the students’ understanding of diversity. The questionnaire was distributed electronically among students from the Faculty of Economics – Skopje, Ss. Cyril and Methodius University in Skopje. The analysis of the responses on Reaction-to-Diversity Inventory has shown that most of the students relate diversity with the term unity (47), which refers to the organizational outcomes as one of the dimensions of diversity. Besides referring to the organizational outcomes, it is important to note that unity is a term that has positive connotation. The results from the multiple regression analysis on the sample of 184 respondents, indicate that besides teachers’/professors’ engagement in educating on diversity and students’ gender, students’ academic success should be considered as a predictor of their understanding of diversity (although the statistical association of students’ grade and their understanding of diversity is statistically weaker and negative).
Stream Hub: Video Chat and Live Streaming Platform
Authors: Ahirwar Manoj
Published: December 2024

Summary: With its emphasis on user-centric features, SyncMate is a trailblazing advancement in distant collaboration
that improves digital teamwork. Focusing on smooth file sharing and high-quality video conferencing, SyncMate creates
realistic online meetings where communication is easy. Its user-friendly UI and live chat feature make for a lively conversation
that increases productivity and engagement. SyncMate's ability to accommodate a variety of communication requirements is
demonstrated by its ability to facilitate both private messaging and group collaboration. Its immersive screen-sharing function
also improves clarity and interaction, elevating presentations and group work sessions. SyncMate stands out as an innovator in a
time when constant connectivity is essential, providing an extensive toolkit to revolutionize team communication and
collaboration. This essay investigates the revolutionary effects of SyncMate on modern digital collaboration, highlighting its role
in driving efficiency, creativity, and success in remote workenvironments
FEM Analysis of Crane Hooks with Different Cross Section
Authors: Mereuta Valentin
Published: December 2024

In this paper the 3D model of the crane hook was realized using Autodesk Inventor Professional 2025 and finite
element analysis, was performed using Ansys Workbench, in order to determine the state of stress, deformation and safety factor,
by applying restrictions and loads conditions. Two materials were chosen, for crane hook, in accordance with the specialized
literature. The materials taken for static analysis was Stainless Steel AISI 1020 and 34CrMo4. The FEM analysis of a crane
hook provides critical information for evaluating the design's structural integrity, identifying potential problem areas, and
ensuring that the hook can safely carry the loads it is intended to handle.