bluuebunny/crossref_metadata_2025 huggingface dataset:
Habitat connectivity and resource selection in an expanding bobcat (Lynx rufus) population
Authors: Popescu Viorel D. , Kenyon Madeline , Brown Ryan K. , Dyck Marissa A. , Prange Suzanne , Peterman William E. , Dennison Catherine
Published: November 2021

Terrestrial carnivores are among the most imperiled species worldwide, yet some species are resilient and are recovering in human-dominated landscapes after decades or centuries of absence. Bobcat (Lynx rufus) populations were extirpated from much of Midwestern US in the mid-1800’s, and are currently expanding and recolonizing their former range. In this study, we investigated multi-scale habitat selection for Ohio’s expanding bobcat population, and examined habitat connectivity in order to evaluate the conduits for dispersal statewide. We used citizen observations collected between 1978 and 2019 and logistic regression to evaluate population-level habitat selection, and GPS telemetry data for 20 individuals collected between 2012 and 2014 and a distribution-weighted exponential Resource Selection Function to evaluate individual-level habitat selection within home ranges. At the population level, bobcats selected for higher amounts of forest and pasture (at a 50 km2scale) and herbaceous vegetation (at 15–50 50 km2scales), thus overall heterogeneous forested habitat. At individual (home range) level, bobcats selected for forested habitats with low road density and farther away from high traffic roads; they also showed weak selection for open habitat at the home range level. Male home ranges were significantly greater than female home ranges. Lastly, we used the population-level spatial outputs (i.e. habitat suitability map) to parameterize habitat connectivity models using circuit theory in the program Circuitscape. We tested three relationships between habitat suitability and resistance to movement and used a subset of data on potential dispersing individuals to evaluate which relationship performed best. All three relationships performed almost equally well, and we calculated a weighted averaged connectivity map as our final map. Habitat was highly permeable to movements between core areas of two genetically distinct subpopulations located in southeastern Ohio. We also identified potential dispersal corridors from the core areas to other regions of Ohio dominated by agriculture and suburban developmentviaforested riparian corridors. Overall, our analysis offers new information on habitat selection and connectivity in a rebounding felid population and offers important ecological information for wildlife management strategies. We recommend that the suitability and connectivity models should be periodically updated until the population reaches an equilibrium, and be integrated with data from neighboring states for a comprehensive assessment of a conservation success story.
Hairy Projections on Non Hairy Cells- A Case Report
Authors: Das Rhituparna , Mukherjee Sriranjan , Sengupta Moumita
Published: November 2021

Adult T-Cell Leukaemia/Lymphoma (ATLL) is a mature T-cell neoplasm. It is caused by human retrovirus Human T-cell Lymphotropic Virus Type 1(HTLV-1). The neoplastic cells after monoclonal integration begin to express T-cell associated antigens namely CD2, CD3 and CD5. These leukaemic cells are highly pleomorphic in light microscopic appearance and also they have a highly variable clinical presentation ranging from acute to lymphomatous to chronic to smouldering. There is a chance of missed or miss diagnosis due to their morphological and clinical heterogeneity and specialised test like immunophenotyping or flow cytometry is essential for exact categorisation. Authors hereby, report a case of 45-year-old female patient suffering from ATLL whose peripheral smear showed leukaemic cells with unusual hairy projections resembling hairy cell leukaemia posing diagnostic dilemma.
Postpartum Depression: Can Participation in a Psychoeducational Group Therapy Program Help Mothers Better Cope with Their Symptoms?
Authors: Narvaez Linares Nicolás Francisco , Vandette Marie-Pier , Firzly Najat , MacAulay Mark , Aubry Tim
Published: November 2021

Up to 15% of mothers experience postpartum depression (PPD) symptoms. Using a pre—post design, results from two 8-week psychoeducational group programs for mothers with moderate levels of PPD symptoms are presented. Findings show the low-cost program to be a promising secondary preventative intervention for an undertreated population.
Study Materiality dalam Aplikasi Material Upcycle pada Desain Interior
Authors: Noorwatha I Kadek Dwi , Ika I Wayan Balika , Tiaga I Nyoman Adi
Published: November 2021

Materialitas (materiality) yang dapat diartikan sebagai pengaruh dan keberadaan material terhadap manusia dalam ruang interior khususnya material upcycle, keberadaannya semakin mengemuka di era kekinian. Material upcycle yang berasal dari  limbah  justru  dijadikan  nilai  tambah  materialitas  dalam  visualisasi  desain  interior  ruang  komersial.  Penelitian  ini bertujuan  untuk  mendapatkan  perumusan  tentang  prinsip  materialitas  dalam  aplikasi  material  upcycle  pada  desain interior.  Penelitian  ini  menggunakan  metode  observasional  dengan  pendekatan  kualitatif  dengan  membandingkan sumber  literatur  dan  data  lapangan,  untuk  mendapatkan  suatu  pemahaman  sesuai  dengan  tujuan  penelitian.  Temuan penelitian  menunjukkan  adanya  pertimbangan  dalam  memilih  materialitas  material  upcycle  dalam  interior  komersial  di Bali, seperti: (1) Keunikan (2) Tekstur (3) Transformasi (4) Memorabilia dan (5) Kesesuaian dengan Konsep.
Identifikasi Penerapan Biophilic Design pada Interior Fasilitas Pendidikan Tinggi
Authors: Kalonica Kay , Kusumarini Yusita , Rakhmawati Anik
Published: November 2021

Pelajar,  pengajar,  dan  staf  pendidikan  membutuhkan  suatu  fasilitas  pendidikan  tinggi  yang  dapat  meningkatkan  kinerja  dan kenyamanan  pengguna.  Salah  satu  pendekatan  desain  yang  dapat  memenuhi  kebutuhan  tersebut adalah biophilic design. Biophilic design dapat meningkatkan produktivitas dan kreatifitas serta menurunkan tingkat stres. Penerapan biophilic design dalam interior fasilitas pendidikan tinggi perlu diteliti lebih lanjut karena minimnya informasi tentang hal ini. Permasalahan yang dapat dirumuskan adalah  bagaimana  identifikasi  penerapan  biophilic  design  dalam  interior  fasilitas  pendidikan  tinggi  serta  rekomendasi  terapan biophilic design pada interior gedung P1 dan P2 Universitas Kristen Petra. Penelitian kualitatif ini menggunakan pendekatan metode research  through  design  yang  mengadopsi  metode  dan  keterampilan  peneliti  yang  sifatnya  fleksibel.  Hasil  penelitian  ini mengungkapkan  bahwa  identifikasi  penerapan  biophilic  design  pada  interior  fasilitas  pendidikan  tinggi  dapat  dilakukan  dengan menerapkan semua 14 pola biophilic design. Rekomendasi terapan pola biophilic design pada objek studi kasus Gedung P1 dan P2 Universitas Kristen Petra telah disimulasikan dengan menerapkan semua 14 pola biophilic design pada interior ruang melalui ide-ide sketsa konseptual
Implementasi Konsep Eksistensi, Inovasi, Regenerasi pada Interior Pusat Komunitas Ludruk Irama Budaya Sinar Nusantara di Surabaya
Authors: . Immaculata , Wardani Laksmi Kusuma , Frans Stephanie Melinda
Published: November 2021

Ludruk sebagai kesenian tradisional khas Jawa Timur sering dianggap kuno dan telah banyak ditinggalkan masyarakat khususnya di Surabaya.  Akan  tetapi,  salah  satu  kelompok ludruk yang masih bertahan yaitu Komunitas Ludruk Irama Budaya Sinar Nusantara. Demi  mempertahankan  kesenian  ludruk,  komunitas  ini  melakukan  pertunjukkan  setiap  minggu  dan  pengajaraan  pada  anak-anak, sehingga  komunitas  ini  membutuhkan  sebuah  wadah  untuk  melestarikkan  kesenian  ludruk.  Konsep  perancangan  yang  diterapkan terinspirasi dari visi misi komunitas yaitu eksistensi, inovasi, dan regenerasi. Konsep eksistensi ini diterapkan pada organisasi ruang yang terpusat, suasana ruang yang homey, karakter naturalisme, dan sistem self-service. Konsep inovasi diterapkan pada penggunaan teknologi dan ruang multifungsi. Sedangkan, konsep regenerasi diterapkan pada ruang yang openspace dan mudah digunakan untuk semua orang. Dengan desain ini, suasana eksistensi, inovatif, dan regenerasi dapat dirasakan semua orang yang berkunjung.
Perancangan Produk Kriya Interior Berbahan Limbah Kayu Pabrik Gitar Di Ujung Berung Bandung
Authors: Purnomo Agus Dody
Published: November 2021

Salah  satu  permasalahan  di  kota  Bandung  yakni  limbah  industri.  Sebagai  contoh  limbah kayu  dari pabrik gitar Genta. Selama ini penanganan  limbah  tersebut  dengan  membuang  dan  membakar.  Hal  ini  tentu  akan  berdampak  pada  permasalahan  lingkungan. Sementara  limbah  tersebut  merupakan  kayu  yang  sudah  diolah  dan  jenis  kayu  yang  bagus.  Penelitian ini menjawab permasalahan limbah  yang  tidak  bernilai  diolah  menjadi  produk  yang  bernilai  estetis  dan  ekonomis.  Metode  yang  dilaksanakan  melalui  metode perancangan  produk.  Mulai  dari  survei,  analisis,  proses  desain,  workshop,  dan  evaluasi.  Kreatifitas  dan  desain  dibutuhkan  dalam mengolah  limbah  kayu.  Luaran  yang  dihasilkan  dalam  penelitian  ini  adalah  prototype  produk  kriya  interior  yang  siap  diproduksi. Penelitian ini diharapkan mampu menjadi langkah nyata untuk meminimalisir limbah kayu pabrik gitar.
Engineered Cell‐Derived Nanovesicles with CAR and PH20 for Enhanced Targeted Photodynamic Cancer Therapy and Tumor Microenvironment Modulation
Authors: Oh Hyeon‐Ji , Park Gwang Yeol , Han Jieun , Son Boram , Han Jun‐Hyeok , Choi Hyomin , Park Chun Gwon , Choi Dong Wook , Park Sung‐Soo , Park Wooram , Park Hee Ho
Published: December 2024

Photodynamic therapy (PDT) is a promising cancer treatment, but its clinical use is limited by nontargeted photosensitizers (PS) that accumulate in normal tissues, causing adverse effects, and poor penetration in tumor tissues due to the dense extracellular matrix (ECM). Here an innovative approach is presented using cell‐derived nanovesicles (CNVs) engineered with chimeric antigen receptor (CAR) and hyaluronidase PH20 to enhance targeted PDT. The CAR–PH20 CNVs, loaded with the photosensitizer pheophorbide a (PheoA), specifically target HER2‐expressing tumor cells and degrade hyaluronic acid in the tumor microenvironment (TME), improving tumor penetration and drug distribution. In vitro and in vivo experiments demonstrate increased reactive oxygen species (ROS) generation, improved tumor retention, and enhanced therapeutic efficacy compared to conventional methods. When combined with laser irradiation, these CNVs induce significant tumor cell apoptosis and inhibit tumor growth in mouse models, while minimizing toxicity to normal tissues. This platform offers a promising strategy for targeted, TME‐modulating PDT with improved efficacy, and reduced side effects, marking a significant advance in nanodrug‐based cancer therapies.
Dual‐Cascade Responsive H2Se Delivery Nanogels Bearing Selenobenzamide as H2Se Donor for the Treatment of Multidrug Resistant Bacteria Infections
Authors: Li Gangfeng , Feng Zhuoya , Hou Zishuo , Chen Runze , Cui Hannan , Wang Tengjiao , Li Peng
Published: December 2024

Hydrogen selenide (H2Se) as one of the endogenous gaseous signaling molecules for antibacterial gas therapy, faces limitations such as high‐dose toxicity and short half‐life. Herein, a polymeric H2Se delivery nanogel (H2Se‐NG) incorporated with aldehyde‐modified selenobenzamide (SeAs) is designed for multidrug resistant (MDR) related healthcare‐associated infections (HAIs) treatment. H2Se‐NG facilitates a dual‐cascade responsive release of H2Se over 72 h, effectively addressing the safety issues caused by the rapid hydrolysis of traditional inorganic H2Se delivery methods. In vitro and in vivo studies demonstrate that nontoxic doses of H2Se‐NG at 150 µg mL−1 not only eliminated over 99% of MDR bacteria and their biofilm within 8 h while reducing levels of proinflammatory cytokines postinfection. Additionally, RNA sequencing results reveal that the released H2Se induces oxidative stress at infection site, kills biofilm‐embedded methicillin‐resistant Staphylococcus aureus (MRSA) and leads biofilm elimination by activating biofilm dispersion genes, suggesting the potential of H2Se‐NG as a promising strategy in antibacterial gas therapy.
Heterogeneous Architecture Light‐Responsive Stiffness‐Tunable Magnetic Actuator
Authors: Wu Chao , Li Jiawei , Zhang Qiankun , Kang Hongjun , Xie Zhimin , Cheng Zhongjun , Tao Qiang , Zhang Dongjie , Liu Yuyan
Published: December 2024

Actuators play important roles in various fields due to their high intelligence. However, the present actuators are hard to achieve high load capacity and easy and fast deformation simultaneously. Here, a novel heterostructure magnetic composite material is proposed, which can work as a matrix to create various actuators by easily tailored and magnetized. Initially, a UV‐responsive stiffness‐tunable polymer (URST‐polymer) is developed using in situ encapsulation of reactive double bonds, achieving a modulus increase of up to 15 600 times after stiffening. By introducing NdFeB@PDA particles into URST‐polymer, the heterostructure matrix is created through a one‐step curing process, which features dual‐functional layers: the layer with NdFeB@PDA particles ensures excellent magnetic actuation properties, while the pure polymer layer guarantees effective UV‐induced stiffening. Consequently, the light‐responsive stiffness‐tunable magnetic actuator (LRST‐MA) made by a heterostructure matrix demonstrates rapid actuation, bistable states, and high stiffness. The URST layer also imparts excellent shape memory properties due to a special polymer network. Combining those advantages with structural and magnetization design, the matrix can be used in applications such as multi‐morphic actuators, variable stiffness grippers, deployable antennas, and emergency robots, which provide a simple and effective strategy for designing actuators.
Critical Role of Nanomaterial Mechanical Properties in Drug Delivery, Nanovaccines and Beyond
Authors: Hui Yue , Liu Yun , Yang Guangze , Weng Yilun , Hou Fei , Wang Xing , Fang Sheng , Gao Huajian , Zhao Chun‐Xia
Published: December 2024

Nanomaterials have become essential in the daily lives, finding applications in food, skincare, drugs, and vaccines. Traditionally, the surface chemistry of nanoparticles (NPs) is considered the key factor in determining their interactions with biological systems. However, recent studies have shown that the mechanical properties of nanomaterials are equally important in regulating nano‐bio interactions, though they have often been overlooked. Tuning the mechanical properties of nanomaterials and designing them for biomedical applications is thus crucial. This review begins by discussing the various mechanical cues in biological processes, including how viruses and cells adjust their mechanical properties throughout their life cycles. Basic concepts and terminology related to NP mechanical properties are introduced. Next, five different groups of nanomaterials with tunable mechanical properties are explored. The review then examines the impact of NP mechanical properties on their interactions in vitro and in vivo, covering tumor‐targeted drug delivery, nanovaccines, and emerging applications such as oral and intranasal drug delivery. Current challenges in the field and perspectives on future developments are also provided.
Bioinspired Heterogeneous Surface for Radiative Cooling Enhanced Power‐Free Moisture Harvesting in Unsaturated Atmosphere
Authors: Zhang Congyuan , Xie Heng , Du Yu , Wu Ting , Wang Zuankai , Qu Jinping
Published: December 2024

The development of zero‐power moisture‐harvesting technology in an unsaturated atmosphere is of great significance for coping with global freshwater scarcity. Here, inspired by Pachydactylus rangei's (Namib sand gecko) ability to evade thermal radiation and harvest moisture, a power‐free cooling moisture harvester (PFCMH) is fabricated using the continuous, industrialized micro‐extrusion compression molding. A Luneburg lens is introduced in the PFCMH for the first time, endowing it with a high reflectivity of ≈92.9% in 0.3 to the 2.5 µm waveband and emissivity of ≈98.1% in 8–13 µm waveband, which are ≈19.2% and ≈15.4% higher than those of the unstructured radiative cooler, respectively. Consequently, a temperature reduction of ≈6.9 °C is achieved. In addition, the wettability of PFCMH is well regulated, at a contact angle of ≈153° and a rolling angle of ≈42°, enabling its surface to efficiently nucleate and transport water droplets. The synergy between the surface and interface functions endows the PFCMH with exceptional passive sub‐dewpoint cooling and efficient harvesting performance. Importantly, every 1 m2 of PFCMH can yield ≈294.5–490.6 kg year−1 of water and save ≈198.7–331.0 kWh year−1 of electricity. The PFCMH offers an environmentally, power‐free, and promising solution to freshwater scarcity.
Stabilizing the Fe Species of Nickel‐Iron Double Hydroxide via Chelating Asymmetric Aldehyde‐Containing THB Ligand for Long‐Lasting Water Oxidation
Authors: Huang Yifan , Kong Fantao , Yu Xu , Yang Tao , Wu Ping , Shen Ruxiang , Zhuo Shangjun , Cui Xiangzhi , Shi Jianlin
Published: December 2024

Nickel‐iron layered double hydroxides (NiFe LDHs) are considered as promising substitutes for precious metals in oxygen evolution reaction (OER). However, most of the reported NiFe LDHs suffer from poor long‐term stability because of the Fe loss during OER resulting in severe inactivation. Herein, a dynamically stable chelating interface through in situ transformation of asymmetric aldehyde‐ligand (THB, 1,3,5‐Tris(3′‐hydroxy‐4′‐formylphenyl)‐benzene) modified NiFe LDHs to anchor Fe and significantly enhance the OER stability is reported. The fabricated asymmetric aldehyde‐containing ligand THB is capable of stimulating much more interfacial charge transfer from NiFe LDHs to the oxygen group of THB and accelerating the formation of highly valent active Fe species leading to the strong combination between Fe and ligand and the reduced activation energy barrier of the intermediate, respectively. The optimized aldehyde‐ligand‐chelated NiFe LDHs (NiFe LDH/THB) shows enhanced OER performance featuring an overpotential of 224 mV at 100 mA cm−2 and robust stability for over 3860 h at 100 mA cm−2 in a water splitting device maintaining a cell voltage of only 1.68 V, which paves a new avenue to improve the water electrolysis performance of non‐noble metal catalysts.
Wireless Printed Large‐Area Sensors for Continuous Structural Health Monitoring
Authors: Hassan Md Farhad , Li Zijie , Islam Mohammad Shafiqul , Gencturk Bora , Zheng Botong , Pan Xiaoying , Khan Yasser , Muin Sifat
Published: December 2024

Structural health monitoring (SHM) is critical to the continuous safety assessment of infrastructure components, particularly for those with concerns over aging and structural deterioration. Traditional strain sensors in SHM often face limitations in sensitivity, durability, and scalability, particularly for large‐area monitoring. In this work, these challenges are addressed by introducing a digitally fabricated strain sensor using additive 3D direct writing technology. The sensor uses a hybrid structure of stretchable carbon and silver materials to improve sensitivity and durability. It achieves dual‐axis strain sensing by positioning carbon elements in both horizontal and vertical directions, enabling 2D strain mapping. A temperature sensor with nickel oxide nanoparticles provides temperature compensation, ensuring accurate strain measurements. To optimize performance, design parameters are fine‐tuned, and comprehensive tests—including static, dynamic, and tensile strength evaluations are performed. The sensor, measuring 5 cm in length and 0.8 mm in width, reaches a maximum gauge factor of 2.45 at room temperature and shows minimal resistance change (0.01%) after 1000 bending cycles with a 5 mm radius. It detects small deformations with a resolution of 0.05%, and dynamic tests, such as earthquake simulations, verify its stability. Tensile testing, using a dynamic servohydraulic Material Testing System (MTS) frame for tension/compression, validates the accuracy of the sensor. This research advances SHM technology by offering a novel digital manufacturing approach for dual‐axis strain sensing, demonstrating the potential of the sensor for continuous, low‐cost, large‐area monitoring.
In Silico Study on the Geometry of Thermal Transducers in Magnetothermal Stimulation
Authors: Midler Noy , Kuznetsova Ekaterina , Shalom Shahar , Begmatova Dilorom , Rosenfeld Dekel
Published: December 2024

Hyperthermia therapy involves the controlled elevation of tissue temperature. It holds promise as a therapeutic modality for various medical applications, including tissue ablation and the activation of thermosensitive cellular mechanisms. This study leverages finite element modeling (FEM) of nanomaterial‐mediated hyperthermia to optimize the geometry of the heat source within the tissue, with the goal of maximizing temperature distribution in solid and hollow organs, tailored for activation of heat‐sensitive ion channels while aspiring to minimize tissue damage or ablation. The models consider physiological factors, such as surrounding fat tissues, vascularization, and fluids, and are developed to match rodent experiments with a scale‐up to human scale organs. The two examined heat source configurations are direct injection of droplets of magnetic nanoparticles versus attached heat‐generating magnetic transducers. The externally attached heat sources prove more effective at achieving therapeutic temperatures with minimal invasiveness, particularly in hollow organs. Furthermore, the simulations demonstrate the importance of heat source volume and density for uniform temperature distribution and reduced tissue damage. Human‐scale models demonstrate the heat source and stimulation duration required for hyperthermia in organs. The suggested model is verified experimentally to match electrogenic cell modulation via heat‐sensitive receptors, paving the way for more precise and safer treatments.
Inhibition of CDH11 Activates cGAS‐STING by Stimulating Branched Chain Amino Acid Catabolism and Mitigates Lung Metastasis of Adenoid Cystic Carcinoma
Authors: Li Rui‐Feng , Liu Shuo , Gao Qian , Fu Min , Sun Xin‐Yi , Xiao Mian , Ge Xi‐Yuan , Peng Xin
Published: December 2024

Salivary adenoid cystic carcinoma (SACC) is an intractable malignant tumor originates in the secretory glands and frequently metastasizes to the lungs. Hybrid epithelial‐mesenchymal transition (EMT) cells within the tumors are correlated with augmented proliferative capacity and facilitation of lung metastasis. Single‐cell RNA sequencing and spatial transcriptomic sequencing are employed to reveal the hybrid EMT subsets within the vascular fibroblast microenvironment. These hybrid EMT cells exhibit a pro‐tumorigenic impact in vitro. Notably, cadherin 11 (CDH11), a specific marker for hybrid EMT cells, may exert its regulatory role in cellular function by interfering with branched‐chain amino acids (BCAA) metabolism by inhibiting branched‐chain ketoacid dehydrogenase to activate the mammalian target of the rapamycin pathway, thus making it a potential therapeutic target for SACC. Furthermore, celecoxib and its derivatives are specific CDH11 inhibitors that regulate BCAA metabolism, increase reactive oxygen species production, and subsequently activate the cyclic GMP‐AMP synthase‐stimulator of the interferongene pathway (cGAS‐STING). They also inhibit lung metastasis in NOD‐SCID mice in vivo. Overall, these findings suggest a promising treatment strategy that targets hybrid EMT cells to mitigate lung metastasis in SACC. Celecoxib may serve as a promising clinical intervention for the treatment of lung metastases in patients with SACC.
Toward Green Liquid Nitrogen Fertilizer Synthesis: Plasma‐Driven Nitrogen Oxidation and Partial Electrocatalytic Reduction
Authors: Qu Zhongping , Hong Jungmi , Gao Yuting , Sun Jing , Huang Jingwen , Zhang Mingyan , Zhu Mengying , Li Tianyu , Wang Xiangyu , Gan Dingwei , Song Qiang , Zhang Tianqi , Zhou Rusen , Liu Dingxin , Cullen Patrick J. , Zhou Renwu
Published: December 2024

Liquid fertilizers, particularly when integrated with precision irrigation systems, offer a more efficient and sustainable alternative to traditional solid nitrogen fertilizers. The industrial production of ammonium nitrate (NH4NO3) is environmentally detrimental due to its reliance on fossil fuels. This study introduces an innovative air‐to‐NOx‐to‐NH4NO3 pathway for synthesizing liquid nitrogen fertilizer. The process employs an underwater multi‐bubble plasma reactor powered by nanosecond pulse to generate aqueous NOx, which is then partially reduced to NH4NO3 through electrocatalysis. Results show that the highest NOx production rate, 786.5 mol h−1, is achieved when the N2/O2 ratio closely resemble that of air, and short pulse rise/fall times significantly increase NOx yield. Further plasma diagnostic and global plasma chemistry modeling indicate that short rise/fall times facilitate simultaneous dielectric barrier discharge and spark discharge, synergistically enhancing nitrogen fixation efficiency. The partially electro‐reduced liquid NH4NO3 fertilizer significantly improves plant growth, with stem length and leaf length increasing by 91.26% and 54.72%, respectively. Cost estimation reveals that 44.22% of the production cost is attributed to electricity consumption, underscoring the potential for optimization with renewable energy integration. Overall, the study provides new insight for the sustainable production and in‐place utilization of liquid nitrogen fertilizers which may advance sustainable agriculture.
Specific Monitoring the DNA Helicase Function via Anchor‐Embedded DNA Probe
Authors: Ning Keni , Tang Xiaoyan , Li Zhe , Zhong Liting , Zhou Yingchen , Wang Jiaen , Huang Wanyi , Zhang Han , Ke Jiajun , Luan Tiangang , Chen Shuo‐Bin , Zhai Junqiu
Published: December 2024

DNA helicases play a pivotal role in maintaining genome integrity by unwinding the DNA double helix and are often considered promising targets for drug development. However, assessing specific DNA helicase activity in living cells remains challenging. Herein, the first anchor‐embedded duplex (ATED) probe, 17GC, is constructed to uniquely monitor the unwinding activity of Werner syndrome helicase (WRN), a clinical anticancer target. This probe integrates biophysical screening and molecular simulation approaches. The 17GC probe consists of two components: the first one is a bubble structure as an anchor for recruiting WRN in cells, and the second one is GC‐rich double helices on both ends of the bubble, which allow high sensitivity in detecting WRN activity. In vitro evaluations demonstrate that 17GC is highly sensitive and specific to WRN (LOD = 33.5 pm) compared to a wide range of other enzymes, including helicases and nucleases. Cellular evaluation reveals that the ATED probe exhibits remarkable performance in monitoring WRN helicase activity and assessing the inhibitory efficiency of clinical WRN inhibitors in various cell types. This study introduces a novel approach for designing specific and sensitive probes for DNA helicases in cells, which holds promise for biological characterization and drug development.
Ferritin‐Based Supramolecular Assembly Drug Delivery System for Aminated Fullerene Derivatives to Enhance Tumor‐Targeted Therapy
Authors: Zhang Baoli , Yang Libin , Jin Yiliang , Lu Yicheng , Li Jianru , Tang Guoheng , Liu Yang , Huo Jiawei , Xu Ran , Wang Chunru , Yan Xiyun , Li Jie , Fan Kelong
Published: December 2024

Owing to their attractive antitumor effects, aminated fullerene derivatives are emerging as promising therapeutic drugs for cancer. However, their in vivo applications are severely limited due to cation toxicity. To address this problem, human heavy chain ferritin (HFn), possessing natural biocompatibility is utilized, to develop a novel supramolecular assembly drug delivery system. Specifically, tetra[4‐(amino)piperidin‐1‐yl]‐C60 (TAPC) is selected as the representative aminated fullerene, and a layer‐by‐layer assembly strategy is designed to controllably assemble TAPC with the negatively charged HFn into a hierarchical coassembly (H@T@H) via electrostatic interactions and hydrogen bonds. In this ordered multilayer structure, the surface displayed HFn endows the inner TAPC with biocompatibility, tumor‐targeting and blood‐brain barrier crossing ability. Additionally, the electrostatic assembly mode enables the acid‐responsive disassembly of H@T@H to release TAPC in lysosomes. In the orthotopic glioma mouse model, the HFn‐assembled TAPC (H@T@H) shows higher brain accumulation and a stronger inhibitory effect on glioma than polyethylene glycol (PEG)‐coated TAPC. Moreover, in an experimental metastasis mouse model, H@T@H have significant preventive and therapeutic effects on tumor metastasis. Encouragingly, the ferritin‐based supramolecular assembly strategy has been proven to have broad applicability for various aminated fullerene derivatives, showing promising potential for tackling the in vivo delivery challenges of cationic drugs.
Redox‐active Co(II) and Zn(II) Pincer Complexes as High‐Capacity Anode Materials for Lithium‐Ion Batteries
Authors: Seong Honggyu , Moon Joon Ha , Jin Youngho , Kim Geongil , Jung Taejung , Yoo Hyerin , Lee Woonghee , Lee Kyounghoon , Cho Se Youn , Choi Jaewon
Published: December 2024

To address the ongoing demand for high‐performance energy storage devices, it is crucial to identify new electrode materials. Lithium‐ion batteries (LIBs) store energy via the electrochemical redox process, so their electrode materials should have reversible redox properties for rechargeability. On that note, redox‐active metal complexes are explored as innovative electrode materials for LIBs. Redox‐active metal(II) chloride complexes (MCC) demonstrate promising potential as anode materials, exhibiting high capacity and excellent rate capability. In particular, zinc(II) chloride complexes, referred to as ZCC, achieve a capacity of 1720 mAh g−1 at 2.0 A g−1 over 200 cycles. Additionally, the lithium‐ion storage mechanism of MCC is elucidated using ex situ analyses of MCC anode's surface in its fully discharged state. The high capacity of the MCC anode is attributed to conversion reaction with Li+ ions forming LiCl and electrodeposition of metallic lithium from the over‐lithiated Li+ ions. These findings support the potential use of redox‐active metal complexes as novel anode materials for LIBs.
On farm soil health assessment across seven sub‐tropical cover crop management systems
Authors: Jesmin Tanjila , Amgain Naba R. , Rabbany Abul , Manirakiza Noel , Capasso Jay , Korus Kevin , Bhadha Jehangir H.
Published: December 2024

The integration of cover cropping in conventional farming systems has shown positive impacts on soil health enhancement. In Florida, where concerns persist about low productivity in mineral soils and significant carbon loss from organic soils, farmers are increasingly adopting cover crops in their routines. This collaborative study aimed to evaluate the immediate effects of cover cropping, comprehend the connections between soil health indicators, and measure quality indices for both mineral and organic soils. Across Florida, we conducted a comprehensive on‐farm study, gathering 272 samples from both mineral and organic surface soils, which were treated with winter or summer cover cropping, rice cultivation, and fallow or flooded fallow. After analyzing 12 health indicators, we employed statistical methods such as mean comparison, non‐parametric correlation, and regression for both pre‐ and post‐cover cropping periods. A modified Comprehensive Assessment of Soil Health scoring system was utilized to assess the quality indices of both soil types. Notably, cover cropping enhanced cation exchange capacity (CEC) and soil protein (SP) in organic soil while preserving an unchanged active carbon (AC) pool. In mineral soils, such practices improved CEC, organic matter, maximum water holding capacity, SP, and total Kjeldahl nitrogen while reducing bulk density and AC. Following cover cropping, correlations among indicators became more pronounced, emphasizing the intricate relationships among soil properties and essential nutrients. Despite this alteration, the health indices did not change in both soils after cover cropping. The study's confined duration, limited to a single cover crop season, may account for the observed impact.
Precision nitrogen management for optimal yield and cannabinoid profile in CBD hemp agronomy
Authors: Panday Dinesh , Acharya Bharat Sharma , Bhusal Nikita , Afshar Reza Keshavarz , Smith Andrew , Ghalehgolabbehbahani Arash
Published: December 2024

Industrial hemp (Cannabis sativa L.), displaying more than 25,000 products, has been grown in North America since the 16th century. However, knowledge gaps persist in optimizing agronomic practices, including precision nitrogen (N) management, which is crucial for yield and phytochemical quality, for example, delta‐9‐tetrahydrocannabinol (THC) and cannabidiol (CBD). Addressing these gaps, a 2‐year field trial (2022 and 2023) was conducted at the Rodale Institute‐Pocono Organic Center in Blakeslee, PA, aiming to optimize CBD hemp production through precision N management. Forty experimental plots were established, with each assessing two main factors: (i) N rate: 0, 56, 112, 168, and 224 kg N ha−1 using an OMRI‐listed fertilizer, blood meal (12% N) and (ii) application method: banding and broadcasting. The 3‐week‐old hemp seedlings were transplanted into main plots, followed by fertilizer application and drip irrigation. Parameters including plant height, bud weight, biomass, and CBD yield were assessed, alongside CBD and THC concentrations in floral components and N concentration in leaves and flowers. There was a significant interaction of N rate and application method, impacting biomass yield, while the N rate also influenced CBD concentration. Blood meal supplied at 224 kg N ha−1 yielded the highest biomass and elevated CBD and THC concentrations; however, this did not differ significantly from 168 kg N ha−1 application. Therefore, the recommended optimal N fertilizer rate for Northeastern CBD hemp production is 168 kg N ha−1, with an upper limit of 224 kg N ha−1. Furthermore, the banding method of fertilizer application was more effective than broadcasting.
Roles of blood monocytes carrying TREM2R47H mutation in pathogenesis of Alzheimer's disease and its therapeutic potential in APP/PS1 mice
Authors: Yu Zhong‐Yuan , Liu Jie , Liu Zhi‐Hao , Liu Xiao‐Yu , Tuo Jin‐Mei , Li Jiang‐Hui , Tu Yun‐Feng , Tan Qi , Ma Yuan‐Yuan , Bai Yu‐Di , Xin Jia‐Yan , Huang Shan , Zeng Gui‐Hua , Shi An‐Yu , Wang Jun , Liu Yu‐Hui , Bu Xian‐Le , Ye Li‐Lin , Wan Ying , Liu Tong‐Fei , Chen Xiao‐Wei , Qiu Zi‐Long , Gao Chang‐Yue , Wang Yan‐Jiang
Published: December 2024

INTRODUCTION

The triggering receptor expressed on myeloid cells 2 (TREM2) arginine‐47‐histidine (R47H) mutation is a significant risk for Alzheimer's disease (AD) with unclear mechanisms. Previous studies focused on microglial amyloid‐β (Aβ) phagocytosis with less attention on the impact of TREM2R47H mutation on blood monocytes.

METHODS

Bone marrow transplantation (BMT) models were used to assess the contribution of blood monocytes carrying TREM2R47H mutation to AD.

RESULTS

Aβ phagocytosis was compromised in mouse monocytes carrying the TREM2R47H mutation. Transplantation of bone marrow cells (BMCs) carrying TREM2R47H mutation increased cerebral Aβ burden and aggravated AD‐type pathologies. Moreover, the replacement of TREM2R47H‐BMCs restored monocytic Aβ phagocytosis, lowered Aβ levels in the blood and brain, and improved cognitive function.

DISCUSSION

Our study reveals that blood monocytes carrying the TREM2R47H mutation substantially contribute to the pathogenesis of AD, and correcting the TREM2R47H mutation in BMCs would be a potential therapeutic approach for those carrying this mutation.

Highlights

TREM2R47H mutation compromises the Aβ phagocytosis of blood monocytes.

Blood monocytes carrying TREM2R47H mutation contribute substantially to AD pathogenesis.

Correction of the TREM2R47H mutation in bone marrow cells ameliorates AD pathologies and cognitive impairments.
MRI free water mediates the association between diffusion tensor image analysis along the perivascular space and executive function in four independent middle to aged cohorts
Authors: Liu Xiaodan , Maillard Pauline , Barisano Giuseppe , Caprihan Arvind , Cen Steven , Shao Xingfeng , Jann Kay , Ringman John M. , Lu Hanzhang , Arfanakis Konstantinos , DeCarli Charles S. , Gold Brian T. , Seshadri Sudha , Satizabal Claudia L. , Beiser Alexa S. , Habes Mohamad , Kramer Joel H. , Stables Lara , Singh Herpreet , Helmer Karl G. , Greenberg Steven M. , Wang Danny J. J. ,   for the MarkVCID Consortium
Published: December 2024

INTRODUCTION

Diffusion tensor image analysis along the perivascular space (DTI‐ALPS) index was proposed for assessing glymphatic clearance function. This study evaluated DTI‐ALPS as a biomarker for cerebral small vessel disease (cSVD) related vascular cognitive impairment and dementia (VCID).

METHODS

Four independent cohorts were examined. A composite score of executive function (UDS3‐EF) was used to evaluate EF status. The association between the ALPS index and UDS3‐EF scores and the mediator effect of free water in white matter (WM‐FW) on such association was analyzed.

RESULTS

The ALPS index was significantly associated with UDS3‐EF scores in all cohorts. Additionally, WM‐FW mediates the relationship between the ALPS index and UDS3‐EF scores.

DISCUSSION

Lower ALPS index may be a surrogate marker of glymphatic dysfunction, which is associated with impaired EF, and this association is mediated by the interstitial fluid (ISF) drainage ISF in WM, providing a clinical rationale for using ALPS index as a biomarker for cSVD‐related VCID.

Highlights

This is the first study to investigate the mediation role of interstitial FW fraction (WM‐FW) on the relationship between glymphatic clearance (ALPS index) and EF (UDS3‐EF scores) in four independent middle to aged cohorts at risk for cSVD.

This study identified that ALPS index was independently associated with UDS3‐EF scores after adjusting for demographics, VRFs, and WM hyperintensity burden and that WM‐FW mediated this association in all middle to aged cohorts.

Our findings suggest that in middle to aged individuals, glymphatic dysfunction (reflected by ALPS index) is strongly associated with EF and that this association is mediated by the ISF drainage in WM.

This study provides a strong clinical rationale for the use of the ALPS index as a marker of cognitive function in multi‐site observational studies and clinical trials to monitor and prevent VCID.
Composite From Superparamagnetic Iron Oxide Nanoparticles and Copper Benzene‐1,3,5‐Tricarboxylate as Rapidly Regenerated CO2 Adsorbent
Authors: Phuong Nguyen Thu , Giang Ha Ngan , Hai Do Thi , Osial Magdalena , Nam Nguyen Hong , Thanh Dinh Thi Mai
Published: December 2024

Rising global warming concerns drive the demand for cost‐effective CO2 capture technologies for industrial reuse. In this study, a novel composite material for CO2 adsorption based on superparamagnetic iron oxide nanoparticles (SPIONs) and copper benzene‐1,3,5‐tricarboxylate (CuBTC) was proposed by a chronoamperometry electrochemical method. XRD, FT‐IR, and SEM–EDX techniques confirmed the presence of SPION and CuBTC in the synthesized composites. SPIONs were small, uniform, and spherical, facilitating their effective combination with CuBTC. Among the synthesized composites, the 1:1 ratio of SPION to CuBTC exhibited the highest CO2 adsorption capacity. Under controlled laboratory conditions (0°C, 1 bar, without the influence of ambient moisture or CO2 diffusion limitations), the SPION/CuBTC 1:1 composite demonstrated a CO2 adsorption capacity of 3.5 mmol/g. Under more realistic conditions (25°C, 1 bar, with the influence of ambient moisture) the SPION/CuBTC 1:1 composite exhibited the highest CO2 adsorption efficiency of 12% (expressed as weigh percentage of dry sorbent). The CO2 adsorption capacity of the composite decreased by more than half when the CO2 concentration dropped from 100% to 15%. The adsorption mechanism is primarily driven by chemical adsorption via surface functional groups and physical adsorption through microcapillary formation and van der Waals interactions, mainly due to CuBTC. The incorporation of SPION in the composite accelerated the CO2 desorption process. The combined magnetic behavior and heat generation results suggest that SPION/CuBTC composites possess enhanced magnetic properties and thermal responses, highlighting their potential for efficient heat‐mediated desorption in industrial applications.
Facile Preparation and Enhanced Visible Light Photocatalytic Performance of AgI/Ag3PO4/WO3·H2O Heterojunction Photocatalysts
Authors: Tang Jianke , Li Qiaoling , Meng Rongqian , Xue Yanfeng , Zhang Shengjian , Shao Shengjuan
Published: December 2024

Using the prepared Ag3PO4/WO3·H2O composite as the matrix, AgI nanoparticles were introduced onto the surface of Ag3PO4 to construct AgI/Ag3PO4/WO3·H2O ternary heterojunction photocatalysts. The ternary composite photocatalysts exhibited higher photocatalytic degradation activities for rhodamine B (RhB) and tetracycline hydrochloride (TCH) than those of binary Ag3PO4/WO3·H2O and AgI/WO3·H2O photocatalysts and individual AgI, Ag3PO4, and WO3·H2O photocatalysts. After exposure to visible light for 12 and 24 min, the removal efficiencies of RhB and TCH by the S2‐50% photocatalyst (50% molar percentage of AgI to Ag3PO4) reached 98.0% and 85.3%, respectively. After four degradation cycles, the removal efficiency of RhB by S2‐50% remained at 93.2%, significantly surpassing that of the Ag3PO4/WO3·H2O photocatalyst. The enhanced photocatalytic performance of the AgI/Ag3PO4/WO3·H2O photocatalyst is primarily attributed to the formation of Z‐scheme/conventional Type II heterojunctions, which facilitate spatial separation of the photogenerated electrons and holes while maintaining the strong reductive capabilities of electrons in the AgI conduction band.
A CNN‐LSTM Method Based on Voltage Deviation for Predicting the State of Health of Lithium‐Ion Batteries
Authors: Xiao Fen , Yang Wei , Ding Yanhuai , Li Xiang , Zhang Kehang , Liu Jiaxiong
Published: December 2024

Ensuring the accurate estimation of the state of health (SOH) of lithium‐ion batteries (LIBs) is essential for the reliability and safe operation of battery management systems. The prediction of SOH has witnessed significant advancements recently, largely propelled by the powerful nonlinear modeling capabilities of deep learning. Despite these advancements, the intricate nature of the battery degradation process poses a challenge in accurately simulating it using measurement data. In this paper, we introduce a novel approach by focusing on the charging voltage deviation, which is defined as the discrepancy between the charging voltage and its average value over each charge/discharge cycle. This deviation is rooted in the electrochemical reactions that lead to capacity decay and voltage fluctuations. We propose a convolutional neural network‐long short‐term memory (CNN‐LSTM) hybrid framework aimed at estimating the SOH of the battery. For each charge/discharge cycle, a conventional CNN is employed to extract key capacity features from sequential charging data, encompassing voltage deviation, current, and charging duration. Following this, an LSTM network is leveraged to build the long‐term dependencies of battery capacities, facilitating the SOH prediction process. The experimental results indicate that our model not only simplifies the computational complexity but also significantly enhances the precision of SOH predictions. This innovative approach holds promise for the advancement of battery management systems, ensuring their continued reliability and safety.
Improving the Performance of Potassium Birnessite Cathodes for Sodium‐Ion Batteries by Partial Ion Exchange
Authors: Aranda Manuel , Klee Rafael , Lavela Pedro , Tirado José L.
Published: December 2024

The current study explores the synthesis and electrochemical performance of potassium birnessite as a cathode material for sodium‐ion batteries (SIBs), achieved through partial ion exchange resulting from partial potassium deintercalation followed by sodium intercalation during the first electrochemical cycle. Three samples of potassium birnessite (KB400, KB500, and KB600) are synthesized using a sol–gel method and subsequently calcined at different temperatures to evaluate the influence of crystal water and K+ ions on structural stability and their electrochemical performance. X‐ray diffraction analysis confirms the formation of samples with high crystallinity. Additionally, X‐ray fluorescence, X‐ray photoelectron spectroscopy, and thermogravimetric analysis are employed to verify their chemical composition and oxidation states. Among the samples, KB500 exhibits the most favorable electrochemical performance, achieving a specific capacity of 175 mAh g–1 at C/10 when cycled within a voltage range of 1.6–4.2 V. Long‐term cycling tests at a narrower potential range of 2–3.6 V demonstrate promising values of 110 mAh g–1 in capacity for KB500, with a retention of 90% over 80 cycles. The presence of potassium and interlayer water is crucial for enhancing structural stability and ion diffusion. These findings suggest that KB500 could serve as a promising cathode material for SIBs, providing a structurally stable option for energy storage applications.
Bioinspired Coordination for Fabricating Self‐healing and Injectable Hydrogels with Antibacterial and Immunoregulatory Activities†
Authors: Diao Youlu , Gao Jia , Li Xinrui , Wang Miao , Pan Guoqing
Published: December 2024

Comprehensive Summary

Inspired by the molecular mechanism of mussel adhesion, here, we developed a class of injectable and self‐healing hydrogels based on natural polysaccharide hyaluronic acid (HA). The dynamic property of hydrogels is derived from histidine‐metal coordination, which widely exists in the mussel adhesive plaque. To mimic components of mussel byssal threads, we first grafted histidine‐containing peptides onto the HA chains. Followed by the addition of Zn2+ ions, the modified HA could then transform into a pH‐sensitive hydrogel network (HA‐His‐Zn) with tunable sol‐gel transitions. The dynamic metal‐ligand coordination could significantly enhance the mechanical properties of HA hydrogels and also endow them with self‐healing and injectable abilities. In addition, the HA‐His‐Zn hydrogels could also exhibit antibacterial and immunoregulatory activities due to the bioactive Zn2+ ions. These results, together with the dynamic properties and good biocompatibility, indicated that the HA‐His‐Zn hydrogels could be applied as a class of easy‐to‐handle scaffold materials for regeneration medicine, particularly for tissue traumas with chronic inflammations and infections.
Catalytic Difunctionalization of Alkenes under Visible Light Irradiation: Synthesis of Iminofuranones
Authors: Liu Boyu , Chen Guangxian , Zhang Lele , Yan Feiwei , Li Feiming , Cai Zhixiong , Huang Mingqiang , Cai Lina , Cai Shunyou
Published: December 2024

Comprehensive Summary

Here, we show a cost‐effective and environmentally friendly method for synthesizing iminofuranones using visible light and the photocatalyst 2‐bromoanthraquinone. Our approach uses only oxygen as the oxidant, avoiding the need for additional transition metals and strong oxidizing agents. By employing a mixed solvent system of DMF and CHCl3 under ambient conditions, we have achieved highly diastereoselective conversions of various 2‐vinyl benzamides and alkenyl amides into functionalized iminoisobenzofuranones and iminofuranones. This versatile process is broadly applicable and enables late‐stage structural modifications of complex substrates with bioactive moieties.