bluuebunny/crossref_metadata_2025 huggingface dataset:
$$H^1$$-conforming finite element cochain complexes and commuting quasi-interpolation operators on Cartesian meshes
Authors: Bonizzoni Francesca , Kanschat Guido
Published: April 2021

A finite element cochain complex on Cartesian meshes of any dimension based on the $$H^1$$

H
1

-inner product is introduced. It yields $$H^1$$

H
1

-conforming finite element spaces with exterior derivatives in $$H^1$$

H
1

. We use a tensor product construction to obtain $$L^2$$

L
2

-stable projectors into these spaces which commute with the exterior derivative. The finite element complex is generalized to a family of arbitrary order.
The First Droplet in a Cloud Chamber Track
Authors: Schonfeld Jonathan F.
Published: April 2021

In a cloud chamber, the quantum measurement problem amounts to explaining the first droplet in a charged-particle track; subsequent droplets are explained by Mott’s 1929 wave-theoretic argument about collision-induced wavefunction collimation. I formulate a mechanism for how the first droplet in a cloud chamber track arises, making no reference to quantum measurement axioms. I look specifically at tracks of charged particles emitted in the simplest slow decays, because I can reason about rather than guess the form that wave packets take. The first visible droplet occurs when a randomly occurring, barely-subcritical vapor droplet is pushed past criticality by ionization triggered by the faint wavefunction of the emitted charged particle. This is possible because potential energy incurred when an ionized vapor molecule polarizes the other molecules in a droplet can balance the excitation energy needed for the emitted charged particle to create the ion in the first place. This degeneracy is a singular condition for Coulombic scattering, leading to infinite or near-infinite ionization cross sections, and from there to an emergent Born rule in position space, but not an operator projection as in the projection postulate. Analogous mechanisms may explain canonical quantum measurement behavior in detectors such as ionization chambers, proportional counters, photomultiplier tubes or bubble chambers. This work is important because attempts to understand canonical quantum measurement behavior and its limitations have become urgent in view of worldwide investment in quantum computing and in searches for super-rare processes (e.g., proton decay).
What Is Frailty? Perspectives from Chinese Clinicians and Older Immigrants in New Zealand
Authors: Cheung Gary , Gee Susan , Jamieson Hamish , Berger Ulrich
Published: April 2021

This qualitative study explores the meanings of frailty held by Chinese New Zealanders and Chinese health care professionals with the aim of identifying commonalities as well as potential differences. Two guided focus groups with Mandarin and Cantonese speaking older adults (n = 10), one individual interview with a English speaking older Chinese, and one focus group with Chinese New Zealand health care professionals (n = 7) were held to obtain views on frailty in older adults, followed by transcribing and a thematic qualitative analysis. Three main themes emerged: (1) Frailty is marked by ill-health, multiple chronic and unstable medical comorbidities, and is a linked with polypharmacy; (2) Frailty can involve physical weakness, decline in physical function such as reduced mobility or poor balance, and declining cognitive function; and (3) Frailty is associated with psychological and social health including depression, reduced motivation, social isolation, and loss of confidence. The perspectives of frailty that emerged are congruent with a multi-dimensional concept of frailty that has been described in both Chinese and non-Chinese medical research literature.
Explicationist Epistemology and the Explanatory Role of Knowledge
Authors: Olsson Erik J.
Published: April 2021

It has been argued that much of contemporary epistemology can be unified under Carnap’s methodology of explication, which originated in the neighboring field of philosophy of science. However, it is unclear to what extent epistemological theories that emphasize the explanatory role of knowledge fit into this picture, Kornblith’s natural kind epistemology and Williamson’s knowledge first approach being cases in point. In this connection, I raise three questions. Can we harvest the insights of these approaches without loss in the more standard and less idiosyncratic explicationist framework? Can we do so without falling prey to prominent criticism raised against those approaches? Finally, do the approaches come out as coherent under an explicationist rendering? I argue that in Kornblith’s case the answer to all three questions is essentially in the affirmative. Much of the knowledge first approach is also translatable into explicationism. However, from that perspective, Williamson’s central argument for treating knowledge as undefinable, referring to persistent yet unsuccessful attempts to solve the Gettier problem, amounts to an overreaction to that problem. Leaving explicationism aside, I ask, in the penultimate section, what Williamson’s own philosophical method really amounts to.
Design and characterization of 3D printed, neomycin-eluting poly-L-lactide mats for wound-healing applications
Authors: Singh Mahima , Jonnalagadda Sriramakamal
Published: April 2021

This study evaluates the suitability of 3D printed biodegradable mats to load and deliver the topical antibiotic, neomycin, for up to 3 weeks in vitro. A 3D printer equipped with a hot melt extruder was used to print bandage-like wound coverings with porous sizes appropriate for cellular attachment and viability. The semicrystalline polyester, poly-l-lactic acid (PLLA) was used as the base polymer, coated (post-printing) with polyethylene glycols (PEGs) of MWs 400 Da, 6 kDa, or 20 kDa to enable manipulation of physicochemical and biological properties to suit intended applications. The mats were further loaded with a topical antibiotic (neomycin sulfate), and cumulative drug-release monitored for 3 weeks in vitro. Microscopic imaging as well as Scanning Electron Microscopy (SEM) studies showed pore dimensions of 100 × 400 µm. These pore dimensions were achieved without compromising mechanical strength; because of the “tough” individual fibers constituting the mat (Young’s Moduli of 50 ± 20 MPa and Elastic Elongation of 10 ± 5%). The in vitro dissolution study showed first-order release kinetics for neomycin during the first 20 h, followed by diffusion-controlled (Fickian) release for the remaining duration of the study. The release of neomycin suggested that the ability to load neomycin on to PLLA mats increases threefold, as the MW of the applied PEG coating is lowered from 20 kDa to 400 Da. Overall, this study demonstrates a successful approach to using a 3D printer to prepare porous degradable mats for antibiotic delivery with potential applications to dermal regeneration and tissue engineering.
The Role of Worldview in Moral Case Deliberation: Visions and Experiences of Group Facilitators
Authors: Spronk Benita , Widdershoven Guy , Alma Hans
Published: April 2021

This study investigates the role of worldview in moral case deliberation (MCD). MCD is a form of clinical ethics support which aims to assist caregivers in reflection on moral dilemmas, experienced in daily practice. Bioethicists acknowledge that existential and religious aspects must be taken into account in the analysis of ethical questions, but it remains unclear how these elements are addressed in clinical ethics support. We investigated how facilitators of MCD address worldview in MCD. MCD facilitation is often done by spiritual caregivers, but not in their role as spiritual caregiver. Discussing worldview is no standard part of the procedure in MCD. This study was qualitative, focusing on the views and experiences of the facilitators of MCD. Semi-structured interviews (N = 12) were conducted with facilitators of MCD. Grounded theory was used for analysis. The results show that worldview plays both an explicit and an implicit role in the MCD process. The explicit role concerns the religious beliefs of patients and professionals. This calls for avoiding stereotyping and devoting attention to different visions. The implicit role comes to the fore in addressing core values and spiritual fulfillment. In order to clarify the fundamental nature of values, more explicit attention for worldview might be useful during MCD. However, this should be done with caution as the term ‘worldview’ might be interpreted by participants in terms of religious and personal beliefs, rather than as an invitation to reflect on one’s view of the good life as a whole.
Ensemble-Based Seismic and Production Data Assimilation Using Selection Kalman Model
Authors: Conjard Maxime , Grana Dario
Published: April 2021

Data assimilation in reservoir modeling often involves model variables that are multimodal, such as porosity and permeability. Well established data assimilation methods such as ensemble Kalman filter and ensemble smoother approaches, are based on Gaussian assumptions that are not applicable to multimodal random variables. The selection ensemble smoother is introduced as an alternative to traditional ensemble methods. In the proposed method, the prior distribution of the model variables, for example the porosity field, is a selection-Gaussian distribution, which allows modeling of the multimodal behavior of the posterior ensemble. The proposed approach is applied for validation on a two-dimensional synthetic channelized reservoir. In the application, an unknown reservoir model of porosity and permeability is estimated from the measured data. Seismic and production data are assumed to be repeatedly measured in time and the reservoir model is updated every time new data are assimilated. The example shows that the selection ensemble Kalman model improves the characterisation of the bimodality of the model parameters compared to the results of the ensemble smoother.
The Berezin Transform of Toeplitz Operators on the Weighted Bergman Space
Authors: Tong Cezhong , Li Junfeng , Arroussi Hicham
Published: April 2021

In this paper, we obtain some interesting reproducing kernel estimates and some Carleson properties that play an important role. We characterize the bounded and compact Toeplitz operators on the weighted Bergman spaces with Békollé-Bonami weights in terms of Berezin transforms. Moreover, we estimate the essential norm of them assuming that they are bounded.
Performance and acceptance when using tablets as a multiple document learning tool: do application and guidance matter?
Authors: Lombard Jordan , Bråten Ivar , van de Leemput Cécile , Amadieu Franck
Published: April 2021

This study addressed whether an application adapted to working with multiple documents implemented in an iPad Pro tablet would promote students’ multiple document comprehension and acceptance of tablets as a multiple document learning tool relative to controls who used a traditional application adapted to sequential reading of single documents. Results indicated that students using the multiple document reading application outperformed the control students in terms of comprehension and also worked more efficiently on the assigned multiple document task, but only if given explicit guidance in selecting, organizing, and integrating information by utilizing the functions of the application. Still, after task completion, the more effective and efficient students guided in using the functions of the multiple document reading application displayed much less acceptance of tablets as a multiple document learning tool than did the control students. We discuss possible explanations for this intriguing performance-acceptance paradox and suggest some avenues for future research in this area.
Diagnostic utility of alarm features in predicting malignancy in patients with dyspeptic symptoms
Authors: Shetty Anurag , Balaraju Girisha , Shetty Shiran , Pai Cannanore Ganesh
Published: April 2021

Background

Clinical features are of modest benefit in determining the etiology of dyspepsia. Dyspeptic patients with alarm features are suspected to have malignancy; but the proportions of patients and true cutoff values of various quantitative parameters in predicting malignancy are explored to a lesser extent.

Methods

This is a prospective observational study of consecutive patients undergoing esophagogastroduodenoscopy (EGD) for dyspeptic symptoms. Patients’ alarm features and clinical details were recorded in a predesigned questionnaire. The diagnostic accuracy of alarm features in predicting malignancy was studied.

Results

Nine hundred patients, 678 (75.3%) males, with a mean (standard deviation [SD]) age of 44.6 (13.54) years were enrolled. Commonest indication for EGD was epigastric pain in 614 (68.2%) patients. Dyspepsia was functional in 311 (34.6%) patients. EGD revealed benign lesions in 340 (37.8%) and malignancy in 50 (5.5%) patients. Among the malignant lesions, gastric malignancy was present in 28 (56%) and esophageal malignancy in 20 (40%) patients. Alarm features were present in 206 (22.9%), out of which malignant lesions were seen in 46 (22.3%) patients. Altogether, the alarm features had a sensitivity of 92% and specificity of 81.2% for predicting malignancy. The sensitivity and specificity for weight loss were 76% and 90.8%, while that of abdominal mass were 10% and 99.9% respectively. Based on receiver operating characteristic curve, the optimal age for screening of malignancy was 46.5 years in this population.

Conclusions

Patients of age group 40 to 49 years with dyspeptic alarm symptoms (predominant weight loss) need prompt endoscopy to screen for malignancy. The alarm features are inexpensive screening tools, found to be useful in India, and should be utilized in countries with similar healthcare conditions and disease epidemiology.
Coeffects of diet and neonicotinoid exposure on honeybee mobility and food choice
Authors: Vodovnik Chiara , Borshagovski Anna-Maria , Hakala Sanja Maria , Leponiemi Matti , Freitak Dalial
Published: April 2021

Malnutrition and pesticide exposure are severe factors contributing to the current losses of honeybee colonies. As these stressors often occur combined, we studied the synergistic effects of different diets and pesticide exposure on food choice and mobility of Apis mellifera. We fed beehives with different food sources and exposed the bees to sublethal doses of thiacloprid. After that three different types of honey and pollen were offered in separate choice assays and behaviour towards food was recorded. Thiacloprid significantly affected the food choice in the honey assay, increasing the bees’ preference of polyfloral honey, while pre-pesticide diet had no influence. The pollen choice remained similar regardless of treatments, as bees always preferred polyfloral pollen. Interestingly, pesticide exposure affected bee mobility differently, depending on the previous diet. These results indicate that the diet is an important factor influencing the susceptibility to pesticides.
Effect of different variants of filler metal S Ni 6625 on properties and microstructure by additive layer manufactured using CMT process
Authors: Zinke Manuela , Burger Stefan , Arnhold Julius , Jüttner Sven
Published: April 2021

The influence of arc energy and different filler metal composition on the mechanical properties and macro- and microstructure of additively welded thin-walled structures of Ni-based alloy were investigated using four different variants commercially available solid wire electrodes of type S Ni 6625. As the welding process, the Cold Metal Transfer (CMT) process was used. The heat input and cooling rate were varied by adjusting wire feed and travel speed. The results show that an increase in arc energy leads to longer t10/6 cooling times. This leads to an increase in the dendrite arm spacing and thus to a reduction in the strength values and hardness of the thin-walled structures. The higher Fe-containing variant of S Ni 6625 produces the highest strength and hardness values, while the W-alloyed solid wire electrode produces the lowest values. The porosity in the walled structures was very low, and unacceptable weld defects, hot cracks and lack of fusion did not occur. Segregations occur in all weld metal specimens. While niobium, molybdenum and titanium are the preferred segregations in the Nb-alloyed Ni 6625 type weld metal, only Mo is present in the W-alloyed Ni 6660 type weld metal.
I-surfaces with one T-singularity
Authors: Franciosi Marco , Pardini Rita , Rana Julie , Rollenske Sönke
Published: April 2021

We classify normal stable surfaces with $$K_X^2 = 1$$

K
X
2

=
1

, $$p_g = 2$$

p
g

=
2

and $$q=0$$

q
=
0

with a unique singular point which is a non-canonical T-singularity, thus exhibiting two divisors in the main component and a new irreducible component of the moduli space of stable surfaces $${{\overline{{{\mathfrak {M}}}}}}_{1,3}$$

M
¯

1
,
3

.
Teutonic Metal: Effects of Place- and Mythology-based Labels on Record Production
Authors: Herbst Jan-Peter
Published: April 2021

Viking, Mesopotamian and Hellenic metal; place-based metal labels full of mythology are commonplace in metal music. Focusing on ‘Teutonic’ metal, this article analyses such labels through a collaboration with one of the genre’s primary record producers: Karl Bauerfeind. Reflection on sixteen selected album productions with German, British, Swedish and Brazilian bands suggests that imagined communities with symbolic boundaries and shared invented traditions not only shape fan and media discourse but have tangible effects and sonic signatures in record productions, as demonstrated by discussions between bands, producers and record companies. The findings suggest that place- or mythology-based labels evoke vivid, partly fictional, historical inspiration for artists and record producers, which are further negotiated in journalistic media and fan discourse. It is suggested that these imagined communities with respective sonic signatures are both meaningful for fans in their ‘communicative leisure’ practices and used by the music industry as ‘instrumental leisure’ in their marketing efforts.
An Intra-Hindu Comparative Analysis of Caitanya Vaiṣṇavism’s Eco-Theological Motifs
Authors: Gupta Akshay
Published: April 2021

In the midst of the earth’s pressing climate catastrophe, the nexus between ecology and religion merits further investigation. In this article, I attempt to illuminate certain important aspects of this nexus by analyzing various Hindu eco-theological motifs, with a particular focus on those of the Hindu religious tradition known as Caitanya Vaiṣṇavism. I will compare and contrast the eco-theological motifs of Caitanya Vaiṣṇavism with those of other notable Hindu religious traditions and texts. Ultimately, I attempt to demonstrate that certain Caitanya Vaiṣṇava eco-theological motifs can, when properly interpreted and applied, serve as valuable environmentally oriented conceptual resources. I also argue that these eco-theological motifs can offset some of the conceptual pitfalls that limit the effectiveness of various pan-Hindu eco-theological motifs as conceptual resources for environmental amelioration. Although the Caitanya Vaiṣṇava eco-theological framework is not without conceptual hurdles, I nevertheless maintain that Caitanya Vaiṣṇava eco-theological motifs are worthy of further reflection.
The Curious Douglas-Fir (Pseudotsuga Menziesii) Trees in Schulman Grove, Mesa Verde National Park, Southwestern Colorado, USA
Authors: Nash Stephen E. , Towner Ronald H. , Dean Jeffrey S.
Published: April 2021

In 1954, archaeologists James Allen Lancaster and Don Watson and dendrochronologist Edmund Schulman asserted that a small grove of Douglas-fir (Pseudotsuga menziesii [Mirbel] Franco var. glauca [Beissener] Franco) trees in Navajo Canyon on the west side of Chapin Mesa in Mesa Verde National Park contained evidence of stone-axe-cut tree limbs. In 1965, archaeologists Robert Nichols and David Smith published an article entitled “Evidence of Prehistoric Cultivation of Douglas-Fir Trees at Mesa Verde,” in which they supported the Lancaster/Watson/Schulman assertion with tree-ring dates from suspected stone-axe-cut limbs. If correct, Nichols and Smith (1965) document the only trees in the entire U.S. Southwest that contain ancient stone-axe-cut stubs and evidence of precolumbian forest management. Rather than accept their interpretations at face value, we attempt to replicate their dates through the (re)analysis of archived and recently collected tree-ring samples, and through a controlled analysis and comparison of archived and published records. We could not confirm their results, and we have no option but to reject their claim that Schulman Grove contains evidence of precolumbian tree manipulation by Ancestral Puebloan inhabitants of Mesa Verde.
A casting method using contrast-enhanced diethylphthalate for micro-computed tomography of snow
Authors: Lombardo Michael , Schneebeli Martin , Löwe Henning
Published: April 2021

Casting snow is necessary to prevent metamorphism and deformation prior to X-ray micro-computed tomography (μCT) imaging. Current methods are insufficient for large-scale field sampling of snow due to safety considerations associated with the casting medium and/or lengthy sample preparation times. Here, a casting method using contrast-enhanced diethylphthalate (DEP) for μCT of snow is presented. The X-ray contrast of DEP is enhanced with barium titanate nanoparticles (BaTiO3) and iodine (I2). A partially unsupervised, three-phase segmentation method utilizing traditional Gaussian smoothing followed by a three-step process to address transition voxels is also presented. Synthetic images derived from real snow samples are used to evaluate the segmentation method with various configurations of trapped air bubbles. Real snow samples spanning a range of specific surface areas (SSAs) (8–28 m2kg−1) and densities (135–463 kg m−3) are used to assess the performance of the segmentation method on real, cast samples. The method yields SSA, density and correlation length errors of less than 10% for synthetic images with air bubble surface areas less than 333 m−1per sample volume for eight of the nine snow samples. For eight of the nine cast samples, the method yields errors of less than 10% for all three parameters.
Spikes and Variance: Using Google Trends to Detect and Forecast Protests
Authors: Timoneda Joan C. , Wibbels Erik
Published: April 2021

Google search is ubiquitous, and Google Trends (GT) is a potentially useful access point for big data on many topics the world over. We propose a new ‘variance-in-time’ method for forecasting events using GT. By collecting multiple and overlapping samples of GT data over time, our algorithm leverages variation both in the mean and the variance of a search term in order to accommodate some idiosyncracies in the GT platform. To elucidate our approach, we use it to forecast protests in the United States. We use data from the Crowd Counting Consortium between 2017 and 2019 to build a sample of true protest events as well as a synthetic control group where no protests occurred. The model’s out-of-sample forecasts predict protests with higher accuracy than extant work using structural predictors, high frequency event data, or other sources of big data such as Twitter. Our results provide new insights into work specifically on political protests, while providing a general approach to GT that should be useful to researchers of many important, if rare, phenomena.
In memoriam: Albert Somit, PhD
Authors: Peterson Steven A.
Published: April 2021

Abstract

Dr. Albert Somit recently died at 100 years of age. He was a major figure in the development of biopolitics. This essay reflects on his career and his role in helping others in advancing the study of politics and the life sciences.
Do Large Gains Make Willing Sellers?
Authors: Hong Dong , Loh Roger K. , Warachka Mitch
Published: April 2021

Using unique real estate data that allow for accurately measured capital gains, we examine whether sell propensities depend on the magnitude of a seller’s capital gain. We find that short-term sell propensities are flat over losses and increasing in gains. Consistent with their higher sell propensities, selling prices are lower for properties with larger gains. Large-sized short-term stock investments also have sell propensities that are flat over losses and increasing in gains, although the sell propensities of typical-sized short-term stock investments are V-shaped. Our findings provide empirical support for theories of realization utility.
UNIFORM ASYMPTOTICS AND CONFIDENCE REGIONS BASED ON THE ADAPTIVE LASSO WITH PARTIALLY CONSISTENT TUNING
Authors: Amann Nicolai , Schneider Ulrike
Published: April 2021

We consider the adaptive Lasso estimator with componentwise tuning in the framework of a low-dimensional linear regression model. In our setting, at least one of the components is penalized at the rate of consistent model selection and certain components may not be penalized at all. We perform a detailed study of the consistency properties and the asymptotic distribution which includes the effects of componentwise tuning within a so-called moving-parameter framework. These results enable us to explicitly provide a set$\mathcal {M}$such that every open superset acts as a confidence set with uniform asymptotic coverage equal to 1, whereas removing an arbitrarily small open set along the boundary yields a confidence set with uniform asymptotic coverage equal to 0. The shape of the set$\mathcal {M}$depends on the regressor matrix as well as the deviations within the componentwise tuning parameters. Our findings can be viewed as a broad generalization of Pötscher and Schneider (2009,Journal of Statistical Planning and Inference139, 2775–2790; 2010,Electronic Journal of Statistics4, 334–360), who considered distributional properties and confidence intervals based on components of the adaptive Lasso estimator for the case of orthogonal regressors.
BASIC PSYCHOLOGICAL NEEDS, MOTIVATIONAL ORIENTATIONS, EFFORT, AND VOCABULARY KNOWLEDGE
Authors: Alamer Abdullah
Published: April 2021

This study examined an integrated process model of second language motivation based on the framework of self-determination theory (SDT). Specifically, this research investigated the extent to which satisfying basic psychological needs (BPN) are related to SDT orientations and, in turn, to the effort expended and how these factors relate collectively to vocabulary knowledge. Revised scales assessing students’ BPN (the Basic Psychological Needs of Second Language Scale) and SDT orientations (the Self-Determination Theory of Second Language Scale) were considered and tested using a higher-order confirmatory factor analysis solution. The results of the structural model showed that BPN were only directly related to vocabulary knowledge, which indicated their direct importance for the attainment of the vocabulary. No other indirect effects through SDT orientations or effort were identified. Nonetheless, SDT orientations were both directly and indirectly linked to vocabulary knowledge over and above the role of expended effort. The results elucidated motivational pathways that yielded pedagogical implications for language learning.
INTERRATER RELIABILITY IN SECOND LANGUAGE META-ANALYSES
Authors: Norouzian Reza
Published: April 2021

There has recently been a surge of interest in improving the replicability of second language (L2) research. However, less attention is paid to replicability in the context of L2 meta-analyses. I argue that conducting interrater reliability (IRR) analyses is a key step toward improving the replicability of L2 meta-analyses. To that end, I first discuss the foundation of IRR in the context of meta-analytic research. Second, I introduce two IRR measures,S indexandSpecific Agreement, which aid in improving the replicability of meta-analytic research. Third, I offer a flexible R program,meta_rate, to facilitate the conduct of IRR analyses for L2 meta-analyses. Fourth, I apply the R program to an actual meta-analytic L2 coding sheet to demonstrate the practical use of the IRR methods discussed. Finally, I provide interpretive guidelines to assist both L2 meta-analysts and journals with the transparent reporting of the IRR findings.
Dynamics of an infection age-space structured cholera model with Neumann boundary condition
Authors: LIU WEIWEI , WANG JINLIANG , ZHANG RAN
Published: April 2021

This paper investigates global dynamics of an infection age-space structured cholera model. The model describes the vibrio cholerae transmission in human population, where infection-age structure of vibrio cholerae and infectious individuals are incorporated to measure the infectivity during the different stage of disease transmission. The model is described by reaction–diffusion models involving the spatial dispersal of vibrios and the mobility of human populations in the same domain Ω ⊂ ℝn. We first give the well-posedness of the model by converting the model to a reaction–diffusion model and two Volterra integral equations and obtain two constant equilibria. Our result suggest that the basic reproduction number determines the dichotomy of disease persistence and extinction, which is achieved by studying the local stability of equilibria, disease persistence and global attractivity of equilibria.
Insights into migratory connectivity and conservation concerns of Red Knots Calidris canutus in the austral Pacific coast of the Americas
Authors: GHERARDI-FUENTES CAMILA , RUIZ JORGE , NAVEDO JUAN G.
Published: April 2021

Migratory species rely on several distant sites during the annual cycle which makes their conservation more complex than that of non-migratory species. Even one of the most extensively studied migratory shorebirds - the Red Knot Calidris canutus - is currently ‘Near Threatened’ at the global level. Conflicting observations of migratory routes cast uncertainty on the subspecies classification and migratory connectivity of Red Knots in the Pacific coasts of the Americas. To fill essential information gaps, we present the first detailed population morphometrics of Red Knots during the non-breeding season in the southern Pacific coast, along with resightings of these birds throughout the Americas. We also estimated daily rate of weight gain during fuelling based on body mass at captures and known departure dates. Resightings demonstrate reliance on staging areas in both the Mid-continental and Atlantic flyways during the northward migration, and additionally in the Pacific Flyway during southward migration. In addition to the strong connection with several areas also used by C. c. rufa on the North American Atlantic coast, our results show morphometric differences within the ranges of both C. c. rufa and C. c. roselaari. Given the threats faced by Red Knots, the population in Chiloé Archipelago should be treated as a separate conservation unit within interhemispheric conservation programmes for endangered shorebirds within the Americas.
Evaluation of the relationship between ventricular function and serum growth differentiation factor-15 levels in patients with operated tetralogy of Fallot
Authors: Önal Damla , Eroğlu Ayşe G. , Akyel Nazlı G. , Yüksel Esra K. , Karakaş Hasan , Pirdal Betül Z. , Adaletli İbrahim
Published: April 2021

Aim:

Growth differentiation factor-15 is a novel biomarker of increasing importance in cardiovascular diseases. This study aimed to evaluate the relationship between ventricular measurements assessed by cardiac magnetic resonance imaging (MRI) and serum growth differentiation factor-15 levels in children with surgically corrected tetralogy of Fallot.

Materials and method:

Serum growth differentiation factor-15 levels were measured in 40 patients (mean age: 15.2 ± 2.9 years; 52.5% male; 87.5% NYHA I). End-diastolic volume index, end-systolic volume index, and ejection fractions of both ventricles and pulmonary regurgitation fraction were measured on cardiac MRI. The correlation between growth differentiation factor-15 levels and cardiac MRI parameters of the patients was investigated. Also, growth differentiation factor-15 levels of the patients were compared with healthy controls since reference values have not been determined in children.

Results:

The mean growth differentiation factor-15 level was 254.9 ± 6.3 pg/ml in the patient group. There was no correlation between growth differentiation factor-15 levels and cardiac MRI parameters in patients. Also, there was no significant difference in growth differentiation factor-15 levels between the patients and control groups.

Conclusion:

The serum levels of growth differentiation factor-15 were uncorrelated with ventricular size, function, and pulmonary regurgitation fraction assessed by cardiac MRI in children with operated tetralogy of Fallot. Moreover, growth differentiation factor-15 levels were not different in these patients from healthy children.
What do they get out of it? Considering a partnership model in health service research
Authors: Askerud Anna , Jaye Chrystal , Doolan-Noble Fiona , McKinlay Eileen
Published: April 2021

A research study to evaluate the implementation of a long-term conditions model of care provoked questions regarding the potential impact of the researcher’s role in health service research. Traditional methods of qualitative interviewing require researchers to be a disembodied presence, objective, and free from bias. When health service research is conducted by health professionals, role conflict may occur if the topic is one they have expertise in, and therefore the ability to provide guidance or information. An alternative perspective to the idea of an independent and objective researcher is the notion of a partnership. In this research collaboration, participants utilised the interview process to reflect and explore different perspectives, and the researcher bracketed their own participation in the phenomenon being studied. Reflexivity was utilised by both participants and the interviewer to ensure transparency and thus bridge the gap between subjectivity and objectivity in qualitative health service research interviewing.
NORMAL FUNCTIONALS ON LIPSCHITZ SPACES ARE WEAK* CONTINUOUS
Authors: Aliaga Ramón J. , Pernecká Eva
Published: April 2021

Let
$\mathrm {Lip}_0(M)$
be the space of Lipschitz functions on a complete metric space M that vanish at a base point. We prove that every normal functional in

${\mathrm {Lip}_0(M)}^*$
is weak* continuous; that is, in order to verify weak* continuity it suffices to do so for bounded monotone nets of Lipschitz functions. This solves a problem posed by N. Weaver. As an auxiliary result, we show that the series decomposition developed by N. J. Kalton for functionals in the predual of

$\mathrm {Lip}_0(M)$
can be partially extended to

${\mathrm {Lip}_0(M)}^*$
.
TRANSLATIONS BETWEEN LINEAR AND TREE NATURAL DEDUCTION SYSTEMS FOR RELEVANT LOGICS
Authors: STANDEFER SHAWN
Published: April 2021

Anderson and Belnap presented indexed Fitch-style natural deduction systems for the relevant logics R, E, and T. This work was extended by Brady to cover a range of relevant logics. In this paper I present indexed tree natural deduction systems for the Anderson–Belnap–Brady systems and show how to translate proofs in one format into proofs in the other, which establishes the adequacy of the tree systems.
How Will Deforestation and Vegetation Degradation Affect Global Fire Activity?
Authors: Park C. Y. , Takahashi K. , Takakura J. , Li F. , Fujimori S. , Hasegawa T. , Ito A. , Lee D. K.
Published: April 2021

Globally, many parts of fire emissions are driven by deforestation. However, few studies have attempted to evaluate deforestation and vegetation degradation fires (DDF) and predict how they will change in the future. In this study, we expanded a fire model used in the Community Land Model to reflect the diverse causes of DDF. This enabled us to differentiate DDFs by cause (climate change, wood harvesting, and cropland, pastureland, and urban land‐use changes) and seasonality. We then predicted the state of fire regimes in the 2050s and 2090s under RCP 2.6 and RCP 6.0 scenarios. Our results indicate that the area affected by global total fires will decrease from the current 452 to 211–378 Mha yr−1 in the 2090s under RCP 6.0 and to 184–333 Mha yr−1 under RCP 2.6, mainly due to socioeconomic factors such as population and economic growth. We also predict that DDF will decrease from the current 73 million hectares per year (Mha yr−1) to 54–66 Mha yr−1 in the 2090s under RCP 6.0 and 46–55 Mha yr−1 under RCP 2.6. The main contributor to these decreases in DDF burned area was climate change, especially the increasing of precipitation. The impact of future land use change on future DDF was similar or slightly lower than present‐day. South America, Indonesia, and Australia were identified as high‐risk regions for future DDF, mainly due to the expansion of wood harvest and pastureland. Appropriate land and fire management policies will be needed to reduce future fire damage in these areas.
A Detailed, Multi‐Scale Assessment of an Atmospheric River Event and Its Impact on Extreme Glacier Melt in the Southern Alps of New Zealand
Authors: Kropač Elena , Mölg Thomas , Cullen Nicolas J. , Collier Emily , Pickler Carolyne , Turton Jenny V.
Published: April 2021

North‐westerly airflow and associated atmospheric rivers (ARs) have been found to profoundly influence New Zealand’s west coasts, by causing flooding, landslides and extreme ablation and accumulation on glaciers in the Southern Alps. However, the response of local glacier mass balance to synoptic‐scale circulation, including events with ARs, has typically not been investigated by considering mesoscale processes explicitly. In this study, high‐resolution atmospheric simulations from the Weather Research and Forecasting model are used to investigate the mesoscale drivers of an extreme ablation event on Brewster Glacier (Southern Alps), which occurred on February 6, 2011 during the landfall of an AR on the South Island. The following processes were found to be crucial for transferring the high temperature and water vapor contained in the AR into energy available for melt on Brewster Glacier: First, the moist‐neutral character of the air mass enabled the flow to pass over the ridge, leading to the development of orographic clouds and precipitation on the windward side of the orography, and foehn winds on the leeside. These processes fueled melt through longwave radiation and strong turbulent and rain heat fluxes within the high‐condensation environment of the orographic cloud. Second, orographic enhancement occurred due to both cellular convection within the cloud and the combined effect of multiple precipitating systems by the seeder‐feeder‐mechanism. These results indicate the potential importance of AR dynamics for New Zealand’s glaciers. They also illustrate the benefit of mesoscale atmospheric modeling for advancing process understanding of the glacier‐climate relationship in New Zealand.
Distribution and Settling Regime of Transparent Exopolymer Particles (TEP) Potentially Associated With Bio‐Physical Processes in the Eastern Indian Ocean
Authors: Guo Congcong , Sun Jun , Wang Xingzhou , Jian Shan , Abu Noman Md. , Huang Ke , Zhang Guicheng
Published: April 2021

The detailed transparent exopolymer particles (TEP) distribution, sinking behavior and the potential mechanisms behind that were revealed in the upper 200 m water column of the eastern Indian Ocean (EIO). The biological process and nutrient limitation have proved to be non‐negligible, both of which possessed potential functions in controlling the TEP pool. TEP production and fate presented significant subregional variations in the study area. The vertical distributions of TEP displayed coherent declined patterns with depth between the marginal sea and pelagic ecosystems, but the concentration of TEP horizontally decreased from marginal sea to open ocean. Dissimilarly, variable distribution patterns and magnitudes were distinguished between stratified and active current zones with the conclusion that the stratified condition was in favor of downward remove of TEP pool but turbulence facilitated the accumulation of TEP especially in the deep chlorophyll maximum (DCM) layer. Distinct sinking regimes of TEP in the stratified zone were distinguishable between layers, with the regulatory mechanisms in the upper, DCM and lower layer of water column being physical diffusion of denser seawater and solutes, aggregation by biotic and abiotic processes and buoyancy effect by entrained lighter fluid, respectively. By comparing the theoretical and measured sinking rates of TEP‐formed aggregates and considering the complicated and uncontrollable situations in non‐culture scenarios, the coupling effects of physical and biological variables on TEP dynamics were elucidated, thus providing a compelling theory for predicting the downward fate of carbon flux in the field environments.
Polarization-insensitive 3D conformal-skin metasurface cloak
Authors: Xu He-Xiu , Hu Guangwei , Wang Yanzhao , Wang Chaohui , Wang Mingzhao , Wang Shaojie , Huang Yongjun , Genevet Patrice , Huang Wei , Qiu Cheng-Wei
Published: April 2021

Electromagnetic metasurface cloaks provide an alternative paradigm toward rendering arbitrarily shaped scatterers invisible. Most transformation-optics (TO) cloaks intrinsically need wavelength-scale volume/thickness, such that the incoming waves could have enough long paths to interact with structured meta-atoms in the cloak region and consequently restore the wavefront. Other challenges of TO cloaks include the polarization-dependent operation to avoid singular parameters of composite cloaking materials and limitations of canonical geometries, e.g., circular, elliptical, trapezoidal, and triangular shapes. Here, we report for the first time a conformal-skin metasurface carpet cloak, enabling to work under arbitrary states of polarization (SOP) at Poincaré sphere for the incident light and arbitrary conformal platform of the object to be cloaked. By exploiting the foundry three-dimensional (3D) printing techniques to fabricate judiciously designed meta-atoms on the external surface of a conformal object, the spatial distributions of intensity and polarization of its scattered lights can be reconstructed exactly the same as if the scattering wavefront were deflected from a flat ground at any SOP, concealing targets under polarization-scanning detections. Two conformal-skin carpet cloaks working for partial- and full-azimuth plane operation are respectively fabricated on trapezoid and pyramid platforms via 3D printing. Experimental results are in good agreement with numerical simulations and both demonstrate the polarization-insensitive cloaking within a desirable bandwidth. Our approach paves a deterministic and robust step forward to the realization of interfacial, free-form, and full-polarization cloaking for a realistic arbitrary-shape target in real-world applications.
Mutant KRAS drives metabolic reprogramming and autophagic flux in premalignant pancreatic cells
Authors: Suzuki Tatsunori , Kishikawa Takahiro , Sato Tatsuyuki , Takeda Norihiko , Sugiura Yuki , Seimiya Takahiro , Sekiba Kazuma , Ohno Motoko , Iwata Takuma , Ishibashi Rei , Otsuka Motoyuki , Koike Kazuhiko
Published: April 2021

Mutational activation of the KRAS gene occurs in almost all pancreatic ductal adenocarcinoma (PDAC) and is the earliest molecular event in their carcinogenesis. Evidence has accumulated of the metabolic reprogramming in PDAC, such as amino acid homeostasis and autophagic flux. However, the biological effects of KRAS mutation on metabolic reprogramming at the earlier stages of PDAC carcinogenesis are unclear. Here we report dynamic metabolic reprogramming in immortalized human non-cancerous pancreatic ductal epithelial cells, in which a KRAS mutation was induced by gene-editing, which may mimic early pancreatic carcinogenesis. Similar to the cases of PDAC, KRAS gene mutation increased the dependency on glucose and glutamine for maintaining the intracellular redox balance. In addition, the intracellular levels of amino acids were significantly decreased because of active protein synthesis, and the cells required greater autophagic flux to maintain their viability. The lysosomal inhibitor chloroquine significantly inhibited cell proliferation. Therefore, metabolic reprogramming is an early event in carcinogenesis initiated by KRAS gene mutation, suggesting a rationale for the development of nutritional interventions that suppress or delay the development of PDAC.
Repurposing cabozantinib with therapeutic potential in KIT-driven t(8;21) acute myeloid leukaemias
Authors: Su Kuan-Wei , Ou Da-Liang , Fu Yu-Hsuan , Tien Hwei-Fang , Hou Hsin-An , Lin Liang-In
Published: April 2021

Cabozantinib is an orally available, multi-target tyrosine kinase inhibitor approved for the treatment of several solid tumours and known to inhibit KIT tyrosine kinase. In acute myeloid leukaemia (AML), aberrant KIT tyrosine kinase often coexists with t(8;21) to drive leukaemogenesis. Here we evaluated the potential therapeutic effect of cabozantinib on a selected AML subtype characterised by t(8;21) coupled with KIT mutation. Cabozantinib exerted substantial cytotoxicity in Kasumi-1 cells with an IC50 of 88.06 ± 4.32 nM, which was well within clinically achievable plasma levels. The suppression of KIT phosphorylation and its downstream signals, including AKT/mTOR, STAT3, and ERK1/2, was elicited by cabozantinib treatment and associated with subsequent alterations of cell cycle- and apoptosis-related molecules. Cabozantinib also disrupted the synthesis of an AML1-ETO fusion protein in a dose- and time-dependent manner. In a mouse xenograft model, cabozantinib suppressed tumourigenesis at 10 mg/kg and significantly prolonged survival of the mice. Further RNA-sequencing analysis revealed that mTOR-mediated signalling pathways were substantially inactivated by cabozantinib treatment, causing the downregulation of ribosome biogenesis and glycolysis, along with myeloid leukocyte activation. We suggest that cabozantinib may be effective in the treatment of AML with t(8;21) and KIT mutation. Relevant clinical trials are warranted.
E47 upregulates ΔNp63α to promote growth of squamous cell carcinoma
Authors: Xu Jing , Li Fengtian , Gao Ya , Guo Rongtian , Ding Liangping , Fu Mengyuan , Yi Yong , Chen Hu , Xiao Zhi-Xiong Jim , Niu Mengmeng
Published: April 2021

Targeted therapy has greatly improved both survival and prognosis of cancer patients. However, while therapeutic treatment of adenocarcinoma has been advanced greatly, progress in treatment of squamous cell carcinoma (SCC) has been slow and ineffective. Therefore, it is of great importance to decipher mechanisms and identify new drug targets involved in squamous cell carcinoma development. In this study, we demonstrate that E47 plays the distinctive and opposite roles on cell proliferation in adenocarcinoma and squamous cell carcinoma. While E47 suppresses cell proliferation in adenocarcinoma cells, it functions as a oncoprotein to promote cell proliferation and tumor growth of squamous cell carcinoma. Mechanistically, we show that E47 can directly bind to the promoter and transactivate ΔNp63 gene expression in squamous cell carcinoma cells, resulting in upregulation of cyclins D1/E1 and downregulation of p21, and thereby promoting cell proliferation and tumor growth. We further show that expression of E2A (E12/E47) is positively correlated with p63 and that high expression of E2A is associated with poor outcomes in clinical samples of squamous cell carcinoma. These results highlight that the E47-ΔNp63α axis may be potential therapeutic targets for treatment of squamous cell carcinoma.
Correction: Characterization of ferroptosis in kidney tubular cell death under diabetic conditions
Authors: Kim Seonghun , Kang Shin-Wook , Joo Jeongho , Han Seung Hyeok , Shin Huiyoon , Nam Bo Young , Park Jimin , Yoo Tae-Hyun , Kim Gyuri , Lee Pureunchowon , Park Jung Tak
Published: April 2021

A Correction to this paper has been published: https://doi.org/10.1038/s41419-021-03667-y