bluuebunny/crossref_metadata_2025 huggingface dataset:
Pediatric emergency department readiness among US trauma hospitals
Authors: Remick Katherine , Gaines Barbara , Ely Michael , Richards Rachel , Fendya Diana , Edgerton Elizabeth A.
Published: December 2018

BACKGROUND

Pediatric readiness among US emergency departments is not universal. Trauma hospitals adhere to standards that may support day-to-day readiness for children.

METHODS

In 2013 4,146 emergency departments participated in the NPRP to assess compliance with the 2009 Guidelines to Care for Children in the Emergency Department. Probabilistic linkage (90%) to the 2009 American Hospital Association survey found 1,247 self-identified trauma hospitals (levels 1, 2, 3, 4). Relationship between trauma hospital level and weighted pediatric readiness score (WPRS) on a 100-point scale was performed; significance was assessed using a Kruskal-Wallis test and pediatric readiness elements using χ2. Adjusted relative risks were calculated using modified Poisson regression, controlling for pediatric volume, hospital configuration, and geography.

RESULTS

The overall WPRS among all trauma hospitals (1,247) was 71.8. Among those not self-identified as a children's hospital or emergency department approved for pediatrics (EDAP) (1088), Level 1 and 2 trauma hospitals had higher WPRS than level 3 and 4 trauma hospitals, 83.5 and 71.8, respectively versus 64.9 and 62.6. Yet, compared with EDAP trauma hospitals (median 90.5), level 1 general trauma hospitals were less likely to have critical pediatric-specific elements. Common gaps among general trauma hospitals included presence of interfacility transfer agreements for children, measurement of pediatric weights solely in kilograms, quality improvement processes with pediatric-specific metrics, and disaster plans that include pediatric-specific needs.

CONCLUSION

Self-identified trauma hospital level may not translate to pediatric readiness in emergency departments. Across all levels of general non-EDAP, nonchildren's trauma hospitals, gaps in pediatric readiness exist. Nonchildren's hospital EDs (i.e., EDAPs) can be prepared to meet the emergency needs of all children and trauma hospital designation should incorporate these core elements of pediatric readiness.

LEVEL OF EVIDENCE

Care management, level III.
Tranexamic acid suppresses the release of mitochondrial DAMPs and reduces lung inflammation in a murine burn model
Authors: Carter Damien Wilson , Prudovsky Igor , Kacer Doreen , Soul Tee , Kumpel Chloe , Pyburn Kathleen , Palmeri Monica , Kramer Robert , Rappold Joseph
Published: December 2018

BACKGROUND

Severe burn injuries are known to initiate a profound systemic inflammatory response (SIRS) that may lead to burn shock and other SIRS-related complications. Damage-associated molecular patterns (DAMPs) are important early signaling molecules that initiate SIRS after burn injury. Previous work in a rodent model has shown that application of a topical immune modulator (p38MAPK inhibitor) applied directly to the burn wound decreases cytokine expression, reduces pulmonary inflammation and edema. Our group has demonstrated that tranexamic acid (TXA)—in addition to its use as an antifibrinolytic—has cell protective in vitro effects. We hypothesized that administration of TXA after burn injury would attenuate DAMP release and reduce lung inflammation.

METHODS

C57/BL6 male mice underwent a 40% Total Body Surface Area (TBSA) scald burn. Sham animals underwent the same procedure in room temperature water. One treatment group received the topical application of p38MAPK inhibitor after burn injury. The other treatment group received an intraperitoneal administration of TXA after burn injury. Animals were sacrificed at 5 hours. Plasma was collected by cardiac puncture. MtDNA levels in plasma were determined by quantitative Polymerase Chain Reaction (qPCR). Syndecan-1 levels in plasma were measured by ELISA. Lungs were harvested, fixed, and paraffin-embedded. Sections of lungs were stained for antigen to detect macrophages.

RESULTS

Topical p38MAPK inhibitor and TXA significantly attenuated mtDNA release. Both TXA and the topical p38MAPK inhibitor reduced lung inflammation as represented by decreased macrophage infiltration. Syndecan-1 levels showed no difference between burn and treatment groups.

CONCLUSION

Both p38 MAPK inhibitor and TXA demonstrated the ability to attenuate burn-induced DAMP release and lung inflammation. Beyond its role as an antifibrinolytic, TXA may have significant anti-inflammatory effects pertinent to burn resuscitation. Further study is required; however, TXA may be a useful adjunct in burn resuscitation.
Interactions of immediate and long-term action regulation in the course and complications of bipolar disorder
Authors: Lijffijt Marijn , O'Brien Brittany , Salas Ramiro , Mathew Sanjay J. , Swann Alan C.
Published: December 2018

Immediate and long-term mechanisms interact in the regulation of action. We will examine neurobiology and practical clinical consequences of these interactions. Long-term regulation of immediate behavioural control is based on analogous responses to highly rewarding or stressful stimuli: (i) impulsivity is a failure of the balance between activation and inhibition in the immediate regulation of action. (ii) Sensitization is a persistently exaggerated behavioural or physiological response to highly salient stimuli, such as addictive stimuli or inescapable stress. Sensitization can generalize across classes of stimuli. (iii) Impulsivity, possibly related to poor modulation of catecholaminergic and glutamatergic functions, may facilitate development of long-term sensitized responses to stressful or addictive stimuli. In turn, impulsivity is prominent in sensitized behaviour. (iv) While impulsivity and sensitization are general components of behaviour, their interactions are prominent in the course of bipolar disorder, emphasizing roles of substance-use, recurrent course and stressors. (v) Suicide is a complex and severe behaviour that exemplifies the manner in which impulsivity facilitates behavioural sensitization and is, in turn, increased by it, leading to inherently unpredictable behaviour. (vi) Interactions between impulsivity and sensitization can provide targets for complementary preventive and treatment strategies for severe immediate and long-term behavioural disorders. Progress along these lines will be facilitated by predictors of susceptibility to behavioural sensitization.

This article is part of the theme issue ‘Risk taking and impulsive behaviour: fundamental discoveries, theoretical perspectives and clinical implications’.
Why has evolution not selected for perfect self-control?
Authors: Hayden Benjamin Y.
Published: December 2018

Self-control refers to the ability to deliberately reject tempting options and instead select ones that produce greater long-term benefits. Although some apparent failures of self-control are, on closer inspection, reward maximizing, at least some self-control failures are clearly disadvantageous and non-strategic. The existence of poor self-control presents an important evolutionary puzzle because there is no obvious reason why good self-control should be more costly than poor self-control. After all, a rock is infinitely patient. I propose that self-control failures result from cases in which well-learned (and thus routinized) decision-making strategies yield suboptimal choices. These mappings persist in the decision-makers’ repertoire because they result from learning processes that are adaptive in the broader context, either on the timescale of learning or of evolution. Self-control, then, is a form of cognitive control and the subjective feeling of effort likely reflects the true costs of cognitive control. Poor self-control, in this view, is ultimately a result of bounded optimality.

This article is part of the theme issue ‘Risk taking and impulsive behaviour: fundamental discoveries, theoretical perspectives and clinical implications.
Three gaps and what they may mean for risk preference
Authors: Hertwig Ralph , Wulff Dirk U. , Mata Rui
Published: December 2018

Risk preference is one of the most important building blocks of choice theories in the behavioural sciences. In economics, it is often conceptualized as preferences concerning the variance of monetary payoffs, whereas in psychology, risk preference is often thought to capture the propensity to engage in behaviour with the potential for loss or harm. Both concepts are associated with distinct measurement traditions: economics has traditionally relied on behavioural measures, while psychology has often relied on self-reports. We review three important gaps that have emerged from work stemming from these two measurement traditions: first, a description–experience gap which suggests that behavioural measures do not speak with one voice and can give very different views on an individual's appetite for risk; second, a behaviour–self-report gap which suggests that different self-report measures, but not behavioural measures, show a high degree of convergent validity; and, third, a temporal stability gap which suggests that self-reports, but not behavioural measures, show considerable temporal stability across periods of years. Risk preference, when measured through self-reports—but not behavioural tests—appears as a moderately stable psychological trait with both general and domain-specific components. We argue that future work needs to address the gaps that have emerged from the two measurement traditions and test their differential predictive validity for important economic, health and well-being outcomes.

This article is part of the theme issue ‘Risk taking and impulsive behaviour: fundamental discoveries, theoretical perspectives and clinical implications’.
Neural circuitry and mechanisms of waiting impulsivity: relevance to addiction
Authors: Dalley Jeffrey W. , Ersche Karen D.
Published: December 2018

Impatience—the failure to wait or tolerate delayed rewards (e.g. food, drug and monetary incentives)—is a common behavioural tendency in humans. However, when rigidly and rapidly expressed with limited regard for future, often negative consequences, impatient or impulsive actions underlie and confer susceptibility for such diverse brain disorders as drug addiction, attention-deficit hyperactivity disorder (ADHD) and major depressive disorder. Consequently, ‘waiting’ impulsivity has emerged as a candidate endophenotype to inform translational research on underlying neurobiological mechanisms and biomarker discovery for many of the so-called impulse-control disorders. Indeed, as reviewed in this article, this research enterprise has revealed a number of unexpected targets and mechanisms for intervention. However, in the context of drug addiction, impulsive decisions that maximize short-term gains (e.g. acute drug consumption) over longer-term punishment (e.g. unemployment, homelessness, personal harm) defines one aspect of impulsivity, which may or may not be related to rapid, unrestrained actions over shorter timescales. We discuss the relevance of this distinction in impulsivity subtypes for drug addiction with reference to translational research in humans and other animals.

This article is part of the theme issue ‘Risk taking and impulsive behaviour: fundamental discoveries, theoretical perspectives and clinical implications’.
Epstein-Barr virus reprograms human B-lymphocytes immediately in the pre-latent phase of infection
Authors: Mrozek-Gorska Paulina , Buschle Alexander , Pich Dagmar , Schwarzmayr Thomas , Fechtner Ron , Scialdone Antonio , Hammerschmidt Wolfgang
Published: December 2018

Epstein-Barr virus (EBV) is a human tumor virus and a model of herpesviral latency. The virus efficiently infects resting human B-lymphocytes and induces their continuous proliferation in vitro, which mimics certain aspects of EBV’s oncogenic potential in vivo. This seminal finding was made 50 years ago, but how EBV activates primary human B-lymphocytes and how lymphoblastoid cell lines (LCLs) evolve from the EBV-infected lymphocytes is uncertain. We conducted a systematic time-resolved longitudinal study of cellular functions and transcriptional profiles of newly infected naïve primary B-lymphocytes. EBV reprograms these human cells comprehensively and globally. Rapid and extensive transcriptional changes occur within 24 hours of infection and precede any metabolic and phenotypic changes. Within the next 48 hours, the virus activates the cells, changes their phenotypes with respect to cell size, RNA and protein content and induces metabolic pathways to cope with the increased demand for energy, supporting an efficient cell cycle entry on day three post infection. The transcriptional program that EBV initiates consists of three waves of clearly discernable clusters of cellular genes that peak on day one, two, or three and regulate RNA synthesis, metabolic pathways and cell division, respectively. Upon the onset of cell doublings on day four the cellular transcriptome appears to be completely reprogrammed to support the activated and proliferating cell, but three additional clusters of EBV regulated genes adjust the infected immune cells to fine-tune cell signaling, migration, and immune response pathways, eventually. Our study reveals that more than 98 % of the 13,000 expressed genes in B-lymphocytes are regulated upon infection demonstrating that EBV governs the entire biology of its target cell.
Somatic LINE-1 retrotransposition in cortical neurons and non-brain tissues of Rett patients and healthy individuals
Authors: Zhao Boxun , Wu Qixi , Ye Adam Yongxin , Guo Jing , Zheng Xianing , Yang Xiaoxu , Yan Linlin , Liu Qing-Rong , Hyde Thomas M. , Wei Liping , Huang August Yue
Published: December 2018

Mounting evidence supports that LINE-1 (L1) retrotransposition can occur postzygotically in healthy and diseased human tissues, contributing to genomic mosaicism in the brain and other somatic tissues of an individual. However, the genomic distribution of somatic L1Hs (Human-specific LINE-1) insertions and their potential impact on carrier cells remain unclear. Here, using a PCR-based targeted bulk sequencing approach, we profiled 9,181 somatic insertions from 20 postmortem tissues from five Rett patients and their matched healthy controls. We identified and validated somatic L1Hs insertions in both cortical neurons and non-brain tissues. In Rett patients, somatic insertions were significantly depleted in exons—mainly contributed by long genes—than healthy controls, implying that cells carryingMECP2mutations might be defenseless against a second exonic L1Hs insertion. We observed a significant increase of somatic L1Hs insertions in the brain compared with non-brain tissues from the same individual. Compared to germline insertions, somatic insertions were less sense-depleted to transcripts, indicating that they underwent weaker selective pressure on the orientation of insertion. Our observations demonstrate that somatic L1Hs insertions contribute to genomic diversity and MECP2 dysfunction alters their genomic patterns in Rett patients.

Author Summary

Human-specific LINE-1 (L1Hs) is the most active autonomous retrotransposon family in the human genome. Mounting evidence supports that L1Hs retrotransposition occurs postzygotically in the human brain cells, contributing to neuronal genomic diversity, but the extent of L1Hs-driven mosaicism in the brain is debated. In this study, we profiled genome-wide L1Hs insertions among 20 postmortem tissues from Rett patients and matched controls. We identified and validated somatic L1Hs insertions in both cortical neurons and non-brain tissues, with a higher jumping activity in the brain. We further found that MECP2 dysfunction might alter the genomic pattern of somatic L1Hs in Rett patients.
Therapeutic suppression of proteolipid protein rescues Pelizaeus-Merzbacher Disease in mice
Authors: Elitt Matthew S. , Barbar Lilianne , Shick H. Elizabeth , Powers Berit E. , Maeno-Hikichi Yuka , Madhavan Mayur , Allan Kevin C. , Nawash Baraa S. , Nevin Zachary S. , Olsen Hannah E. , Hitomi Midori , LePage David F. , Jiang Weihong , Conlon Ronald A. , Rigo Frank , Tesar Paul J.
Published: December 2018

Mutations in proteolipid protein 1 (PLP1) result in failure of myelination and severe neurological dysfunction in the X-linked pediatric leukodystrophy Pelizaeus-Merzbacher disease (PMD). The majority of PLP1 variants, including supernumerary copies and various point mutations, lead to early mortality. However, PLP1-null patients and mice display comparatively mild phenotypes, suggesting that reduction of aberrant PLP1 expression might provide a therapeutic strategy across PMD genotypes. Here we show, CRISPR-Cas9 mediated germline knockdown of Plp1 in the severe jimpy (Plp1jp) point mutation mouse model of PMD rescued myelinating oligodendrocytes, nerve conduction velocity, motor function, and lifespan to wild-type levels, thereby validating PLP1 suppression as a therapeutic approach. To evaluate the therapeutic potential of Plp1 suppression in postnatal PMD mice, we tested antisense oligonucleotides (ASOs) that stably decrease mouse Plp1 mRNA and protein in vivo. Administration of a single intraventricular dose of Plp1-targeted ASOs to postnatal jimpy mice increased myelination, improved motor behavior, and extended lifespan through an 8-month endpoint. Collectively, these results support the development of PLP1 suppression as a disease-modifying therapy for most PMD patients. More broadly, we demonstrate that RNA therapeutics can be delivered to oligodendrocytes in vivo to modulate neurological function and lifespan, opening a new treatment modality for myelin disorders.
Combinatorial Control through Allostery
Authors: Galstyan Vahe , Funk Luke , Einav Tal , Phillips Rob
Published: December 2018

Many instances of cellular signaling and transcriptional regulation involve switch-like molecular responses to the presence or absence of input ligands. To understand how these responses come about and how they can be harnessed, we develop a statistical mechanical model to characterize the types of Boolean logic that can arise from allosteric molecules following the Monod-Wyman-Changeux (MWC) model. Building upon previous work, we show how an allosteric molecule regulated by two inputs can elicit AND, OR, NAND and NOR responses, but is unable to realize XOR or XNOR gates. Next, we demonstrate the ability of an MWC molecule to perform ratiometric sensing - a response behavior where activity depends monotonically on the ratio of ligand concentrations. We then extend our analysis to more general schemes of combinatorial control involving either additional binding sites for the two ligands or an additional third ligand and show how these additions can cause a switch in the logic behavior of the molecule. Overall, our results demonstrate the wide variety of control schemes that biological systems can implement using simple mechanisms.
Bi-clustering based biological and clinical characterization of colorectal cancer in complementary to CMS classification
Authors: Cao Sha , Chang Wennan , Wan Changlin , Zhang Yong , Zhao Jing , Li Bo , Ma Qin , Zhang Chi
Published: December 2018

In light of the marked differences in the intrinsic biological underpinnings and prognostic outcomes among different subtypes, Consensus Molecular Subtype (CMS) classification provides a new taxonomy of colorectal cancer (CRC) solely based on transcriptomics data and has been accepted as a standard rule for CRC stratification. Even though CMS was built on highly cancer relevant features, it suffers from limitations in capturing the promiscuous mechanisms in a clinical setting. There are at least two facts about using transcriptomic data for prognosis prediction: the engagement of genes or pathways that execute the clinical response pathway are highly dynamic and interactive with others; and a predefined patient stratification not only largely decrease the statistical analysis power, but also excludes the fact that clusters of patients that confer similar clinical outcomes may or may not overlap with a pre-defined subgrouping. To enable a flexible and prospective stratified exploration, we here present a novel computational framework based on bi-clustering aiming to identify gene regulatory mechanisms associated with various biological, clinical and drug-resistance features, with full recognition of the transiency of transcriptional regulation and complicacies of patients subgrouping with regards to different biological and clinical settings. Our analysis on multiple large scale CRC transcriptomics data sets using a bi-clustering based formulation suggests that the detected local low rank modules can not only generate new biological understanding coherent to CMS stratification, but also identify predictive markers for prognosis that are general to CRC or CMS dependent, as well as novel alternative drug resistance mechanisms. Our key results include: (1) a comprehensive annotation of the local low rank module landscape of CRC; (2) a mechanistic relationship between different clinical subtypes and outcomes, as well as their characteristic biological underpinnings, visible through a novel consensus map; and (3) a few (novel) resistance mechanisms of Oxaliplatin, 5-Fluorouracil, and the FOLFOX therapy are revealed, some of which are validated on independent datasets.
31° South: Dietary niche of an arid-zone endemic passerine
Authors: Ribeiro Ângela M. , Smit Ben , Gilbert M. Thomas P.
Published: December 2018

Balancing energy budgets is thought to be challenging for birds living in arid ecosystems because food supplies are low and unpredictable, and climatic conditions extreme. Thus, to ensure they obtain sufficient energy to fuel daily energetic budgets, birds may need to adjust their diets and become less selective (generalist) as conditions become harsher. To test this hypothesis, we used DNA metabarcoding to characterize both the prey availability and the dietary content of several conspecific populations of a semi- and arid-endemic insectivorous bird, the Karoo-scrub-robin (Cercotrichas coryphaeus) across a climatic gradient. Our results showed that Coleoptera, Hymenoptera, Orthoptera, and Lepidoptera were the main prey. When accounting for their presence as available prey, Coleoptera and Hymenoptera were preferred in all regions, whereas robins avoided Orthoptera and Lepidoptera in all but the most arid region. Although the different populations live in regions that vary with regards to productivity and thermoregulatory demands, we found that the dietary niche breadth (Bs) of the three populations was intermediate to low, and did not differ significantly. As a whole, our findings show that regardless of environmental harshness these insectivores have similar dietary niches, suggesting that large dietary plasticity is fundamental for their survival in energy-depauperated ecosystems.
WBC-Profiler: an Unsupervised Feature Learning System for Leukocytes Characterization and Classification
Authors: Yan Hong , Mao Xuanyu , Xia Yongquan , Li Zhiyang , Wang Chengbin , Xia Rui , Xu Xuejing , Wang Zhiqiang , Zhao Xie , Li Yan , Shen Han , Chang Hang
Published: December 2018

The characterization and classification of white blood cells (WBC) is critical for the diagnosis of anemia, leukemia and many other hematologic diseases. We developed WBC-Profiler, an unsupervised feature learning system for quantitative analysis of leukocytes. We demonstrate that WBC-Profiler enables automatic extraction of complex signatures from microscopic images without human-intervention and thereafter effective construction of leukocytes profiles, which decouples large scale complex leukocytes characterization from limitations in both human-based feature engineering/optimization and the end-to-end solutions provided by modern deep neural networks, and therefore has the potential to provide new opportunities towards meaningful studies/applications with scientific and/or clinical impact
Combinations of low-level and high-level neural processes can account for distinct patterns of context-dependent choice
Authors: Spitmaan Mehran , Horno Oihane , Chu Emily , Soltani Alireza
Published: December 2018

Context effects have been explained by either high-level cognitive processes or low-level neural adjustments but not their combination. It is currently unclear how these processes interact to shape individuals’ responses to context. Here, we used a large cohort of human subjects in experiments involving choice between two or three gambles in order to study the dependence of context effects on neural adaptation and individuals’ risk attitudes. We found no evidence that neural adaptation on long timescales (~100 trials) contributes to context effects. However, we identified two groups of subjects with distinct patterns of responses to decoys, both of which depended on individuals’ risk aversion. Subjects in the first group exhibited strong, consistent decoy effects and became more risk averse due to decoy presentation. In contrast, subjects in the second group did not show consistent decoy effects and became more risk seeking. The degree of change in risk aversion due to decoy presentation was positively correlated with the initial degrees of risk aversion. To explain these results and reveal underlying neural mechanisms, we developed a new model that incorporates both low- and high-level processes to fit individuals’ choice behavior. We found that observed decoy effects can be explained by a combination of adjustments in neural representations and competitive weighting of reward attributes, both of which depend on risk aversion but in opposite directions. Altogether, our results demonstrate how a combination of low- and high-level processes shapes multi-attribute choice, modulates overall risk preference, and explains distinct behavioral phenotypes.

Significance statement

A large body of experimental work has illustrated that the introduction of a new, and often irrelevant, option can influence preference among the existing options, a phenomenon referred to as context or decoy effects. Although context effects have been explained by high-level cognitive processes—such as comparisons and competitions between attributes—or low-level adjustments of neural representations, it is unclear how these processes interact to shape individuals’ responses to context. Here, we show that both high-level cognitive processes and low-level neural adjustments shift risk preference during choice between multiple options but in opposite directions. Moreover, we demonstrate that a combination of these processes can account for distinct patterns of context effects in human subjects.
Functional systemic CD4 immunity is a differential factor for clinical responses to PD-L1/PD-1 blockade therapy in lung cancer
Authors: Zuazo Miren , Arasanz Hugo , Fernandez-Hinojal Gonzalo , Garcia-Granda Maria Jesus , Gato Maria , Bocanegra Ana , Hernandez Berta , Martinez Maite , Teijeira Lucia , Morilla Idoia , Lecumberri Maria Jose , Fernandez de Lascoiti Angela , Vera Ruth , Kochan Grazyna , Escors David
Published: December 2018

The majority of lung cancer patients progressing from conventional therapies are refractory to PD-L1/PD-1 blockade monotherapy. Here we show that baseline systemic CD4 immunity is a differential factor for clinical responses. Patients with functional systemic CD4 T cells included all objective responders and could be identified before the start of therapy by having a high proportion of memory CD4 T cells. In these patients CD4 T cells possessed significant proliferative capacities, co-expressed low levels of PD-1/LAG-3 and were responsive to PD-1 blockade ex vivo and in vivo. In contrast, patients with dysfunctional systemic CD4 immunity did not respond even though they had circulating lung cancer antigen-specific CD4 and CD8 T cells. CD4 T cells in these patients proliferated very poorly, strongly co-upregulated PD-1/LAG-3 after stimulation, and were largely refractory to PD-1 monoblockade ex vivo and in vivo. Although baseline CD8 immunity was strongly dysfunctional in all patients before the start of therapy, it only recovered in patients with functional CD4 immunity. CD4 and CD8 T cell dysfunctionality was caused by PD-1/LAG-3 co-expression, which could be reverted by PD-1/LAG-3 co-blockade. Patients with functional CD4 immunity and PD-L1 tumor positivity exhibited response rates of 70%, highlighting the contribution of CD4 immunity for efficacious PD-L1/PD-1 blockade therapy.
Neural response variability and divisive normalization
Authors: Coen-Cagli Ruben , Solomon Selina S
Published: December 2018

Cortical responses to repeated presentations of a stimulus are variable. This variability is sensitive to experimental manipulations that are also known to engage divisive normalization: a widespread description of neural activity as the ratio of a numerator (the excitatory stimulus drive) and denominator (the normalization signal). Yet, we lack a framework to quantify the effects of normalization on response variability. We extended the standard normalization model, treating the numerator and denominator as stochastic quantities, and derived a method to infer the single-trial normalization strength, which cannot be measured directly. The model revealed a general reduction of response variability in macaque primary visual cortex for neurons that were more strongly normalized, and during trials in which normalization was inferred to be strong. This framework could enable a direct quantification of the impact of single-trial normalization on perceptual judgments, and can readily be applied to other sensory and non-sensory factors.
Parallel spatial channels converge at a bottleneck in anterior word-selective cortex
Authors: White Alex L. , Palmer John , Boynton Geoffrey M. , Yeatman Jason D.
Published: December 2018

In most environments, the visual system is confronted with many relevant objects simultaneously. That is especially true during reading. However, behavioral data demonstrate that a serial bottleneck prevents recognition of more than one word at a time. We used functional magnetic resonance imaging (fMRI) to investigate how parallel spatial channels of visual processing converge into a serial bottleneck for word recognition. Observers viewed pairs of words presented simultaneously. We found that retinotopic cortex processed the two words in parallel spatial channels, one in each contralateral hemisphere. Responses were higher for attended words than ignored words, but were not reduced when attention was divided, even though behavioral performance suffered greatly. We then analyzed two word-selective regions along the occipito-temporal sulcus (OTS) of both hemispheres (i.e., sub-regions of visual word form area, VWFA). Unlike retinotopic cortex, each word-selective region responded to words on both sides of fixation. Nonetheless, a single region in the left hemisphere (VWFA-1 in posterior OTS) contained spatial channels for both hemifields that were independently modulated by selective attention. Thus, the left posterior VWFA supports parallel processing of multiple words. In contrast, a more anterior word-selective region in the left hemisphere (VWFA-2 in mid- OTS) showed limited spatial and attentional selectivity, consistent with activity of a single channel. Therefore, the visual system can process two words in parallel up to a late stage in the ventral stream. The transition from two parallel channels to a single channel in more anterior regions is consistent with the observed bottleneck in behavior.
MARK2/Par1b present at retraction fibres corrects spindle off-centering induced by actin disassembly
Authors: Hart Madeleine , Zulkipli Ihsan , Shrestha Roshan Lal , Dang David D , Conti Duccio , Kujawiak Izabela , Draviam Viji M.
Published: December 2018

Tissue maintenance requires adequate cell proliferation and a directed plane of cell division. While it is clear that the division-plane can be determined by retraction fibres that direct spindle movements, the components of retraction fibres that direct spindle movements are poorly understood. We report MARK2/Par1b kinase as a novel component of actin-rich retraction fibres, important for directed spindle movements. A kinase-dead mutant of MARK2 reveals the ability of MARK2 to monitor actin status. MARK2 localisation at actin-rich retraction fibres, but not the rest of the cortical membrane or centrosome, is dependent on its activity, highlighting a specialised spatial regulation of MARK2. By subtly perturbing the actin cytoskeleton, we demonstrate MARK2 has a role in correcting spindle off-centering, induced by actin disassembly. In addition to this mitotic role, we show MARK2 has a post-mitotic role in ensuring normal G1-S transition and cell proliferation. We propose that MARK2 provides a molecular framework to integrate cortical signals and cytoskeletal changes in both mitosis and interphase.
Patient attitudes toward physicians
Authors: Shareef Mahmud Akhter , Dwivedi Yogesh K. , Archer Norm , Rahman Mohammad Mahboob
Published: December 2018

Purpose

Stakeholders affiliated with healthcare services should understand patient attitudes and criteria that are involved in selecting a personal physician. The purpose of this paper is to identify the factors that are significant to patients in selecting or deselecting physicians as providers of healthcare services.

Design/methodology/approach

The research structure was set to theorize the physician selection criteria (PSC) model into two phases. The first phase developed a conceptual model as revealed from healthcare consumer perceptions. The second phase was designed to test and validate the model through cause–effect statistical analysis underpinned by theoretical explanations through an empirical study.

Findings

Through an empirical study of benchmarking perceptions of people from 15 different countries, qualitative PSC were gathered and used to formulate an initial PSC model. Based on the proposed model, a validity test was conducted, and finally, the PSC model was developed, resulting in several interesting and self-explanatory outcomes.

Research limitations/implications

The model was tested in only one (relatively cosmopolitan) city. For proper generalization, it should be tested in countries with differing healthcare service systems.

Practical implications

The results of this study are interesting, important and have potential values to academics and medical professionals. The study provides strong evidence that a physician’s external approach to patients is the most significant issue for patients seeking medical services. This does not refer to basic medical services, but rather the treatment process, where the physician’s behavior and positive attitude has the strongest effect on the patient’s decision to choose one physician over others.

Originality/value

Final PSC model has identified some significant theoretical explanations for academics and professional justifications for practitioners.
Effect of tilt angle on the multi-pipe channel with sinusoidal/curved walls – numerical modelling based on finite volume method
Authors: Hooshmand Payam , Bahrami Mohammad , Bagheri Navid , Jamshidian Meysam , Hasani Malekshah Emad
Published: December 2018

Purpose

This paper aims to investigate the two-dimensional numerical modeling of fluid flow and heat transfer in a fluid channel.

Design/methodology/approach

The channel is filled with the CuO-water nanofluid. The KKL model is used to estimate the dynamic viscosity and considering Brownian motion. On the other hand, the influence of CuO nanoparticles’ shapes on the heat transfer rate is taken account in the simulations. The channel is included with several active pipes with hot and cold temperatures. Furthermore, the external curved and sinusoidal walls have cold and hot temperatures, respectively.

Findings

Three different tilt angles are considered with similar boundary and operating conditions. The Rayleigh numbers, solid volume fraction of CuO nanoparticles in the pure water and the tilt angles are the governing parameters. Different cases studies, such as streamlines, heat transfer rate, local and total entropy generation and heatlines, are analysed under influences of these governing parameters.

Originality/value

The originality of this work is investigation of fluid flow, heat transfer and entropy generation within a nanofluid filled channel using FVM.
The impact of innovation strategies on the relationship between supplier integration and operational performance
Authors: Duhaylongsod Jose Benedicto , De Giovanni Pietro
Published: December 2018

Purpose

The purpose of this paper is to investigate whether implementing certain innovation strategies and adopting a portfolio of innovations improve the relationship between supplier integration (SI) and operational performance (OP).

Design/methodology/approach

The authors test several research hypotheses by using a data set of 173 firms. Data were collected by interviewing managers, presidents and directors, from ten European countries and across nine different industries. The authors use structural equation modeling to estimate the relationships between SI and OP. The authors apply multi-group analysis to test the effects of certain innovation strategies and a portfolio of innovations on these relationships.

Findings

The authors show that SI improves internal OP but has no direct effect on external OP. The latter can only be improved through well-performing internal operations. The adoption of an incremental product innovation strategy improves the relationship between internal and external OP and leads to more effective SI. Other types of innovations do not help in improving the impact of SI on OP. Finally, the adoption of a portfolio of innovations does not enhance the influence of SI on OP. Thus, firms should focus on a small number of innovations rather than expanding their innovation portfolio to improve the effectiveness of SI on OP.

Practical implications

When firms aim to improve the impact of SI on OP, they should concentrate on incremental product innovations. Other strategies obtained by combining process, incremental and radical innovations are not adequate for that purpose. An expanded portfolio of innovations does not improve the effect of supplier innovation on OP.

Originality/value

This research suggests how the impact of SI on OP can be improved by adopting certain innovation strategies and without diversifying the portfolio of innovation projects.
Performance indicators of public private partnership in Bangladesh
Authors: Hossain Mohammad , Guest Ross , Smith Christine
Published: December 2018

Purpose

The purpose of this paper is to develop weights of key performance areas (KPAs) and performance indicators for public private partnerships (PPPs) in Bangladesh. Since a variety of PPP arrangements is observable, different performance measurement approaches exist in the literature. However, analysing the relative importance of indicators influencing the performance score of particular projects using the perspective of developing countries remains unexplored.

Design/methodology/approach

The authors’ method involves application of the analytical hierarchy process (AHP) to develop weights for eight KPAs for which 41 contributing performance indicators have been developed. In total, 68 respondents (62 per cent of the PPP practitioners in Bangladesh) participated in a structured questionnaire survey and their judgements have been found to be consistent, using consistency ratios, a geometric consistency index and one-way ANOVA test.

Findings

“Feasibility analysis”, “life cycle evaluation and monitoring” and “optimal risk allocation” are the most significant performance indicators in Bangladesh. “Financing” is the most important KPA, followed by “planning and initiation” and “transparency and accountability”. Interestingly, unlike the cost, time and quality measures of the public sector comparator analysis used in most developed countries, a different set of indicators and KPAs are found dominant.

Research limitations/implications

This suggests that performance indicators and their weights may differ for developing countries. Future research could usefully focus on testing this model in different countries and applying it to derive performance scores for individual PPPs.

Originality/value

An application of AHP in determining weights of the performance indicators represents a major contribution to the literature on PPP performance measurement in the developing countries including Bangladesh.
Methodology for application of Maynard Operation Sequence Technique (MOST) for time-driven activity-based costing (TDABC)
Authors: Ganorkar Ashwin Bhimrao , Lakhe Ramesh R. , Agrawal Kamalkishor N.
Published: December 2018

Purpose

The purpose of this paper is to present a procedure to implement time-driven activity-based costing (TDABC) using Maynard Operation Sequence Technique (MOST). In this paper three research questions are addressed: How can MOST be used to frame time equations? How can MOST be used for the improvement of productivity? How can TDABC cost information be used?

Design/methodology/approach

Case study research was performed at a manufacturing industry. Data have been collected for overhead distribution. The overhead cost was distributed on activity. Time equations are framed using MOST. Cost of activity is assigned to the product using time equations.

Findings

The proposed system simplifies the process of implementation of TDABC using MOST. This system not only determines the cost but also identifies the area where cost is consumed. It also identifies opportunity for productivity improvement.

Research limitations/implications

The case study was conducted in a manufacturing industry. The proposed methodology is suitable for manufacturing industry where standard work procedure is adapted.

Practical implications

The study explains the implementation of TDABC using MOST using a case study and results are meticulously discussed from a management point of view for appropriate decision making.

Originality/value

Besides the articles published so far dealing with the implementation of TDABC, no research was found on the implementation of TDABC using MOST.
Bootstrapped operating efficiency in container ports: a case study in Spain and Portugal
Authors: Gil Ropero Antonio , Turias Dominguez Ignacio , Cerbán Jiménez Maria del Mar
Published: December 2018

Purpose

The purpose of this paper is to evaluate the functioning of the main Spanish and Portuguese containers ports to observe if they are operating below their production capabilities.

Design/methodology/approach

To achieve the above-mentioned objective, one possible method is to calculate the data envelopment analysis (DEA) efficiency, and the scale efficiency (SE) of targets, and in order to consider the variability across different samples, a bootstrap scheme has been applied.

Findings

The results showed that the DEA bootstrap-based approach can not only select a suitable unit which accords with a port’s actual input capabilities, but also provides a more accurate result. The bootstrapped results indicate that all ports do not need to develop future investments to expand port infrastructure.

Practical implications

The proposed DEA bootstrap-based approach provides useful implications in the robust measurement of port efficiency considering different samples. The study proves the usefulness of this approach as a decision-making tool in port efficiency.

Originality/value

This study is one of the first studies to apply bootstrap to measure port efficiency under the background of the Spain and Portugal case. In the first stage, two models of DEA have been used to obtain the pure technical, and the technical and SE, and both the input-oriented options: constant return scale and variable return scale. In the second stage, the bootstrap method has been applied in order to determine efficiency rankings of Iberian Peninsula container ports taking into consideration different samples. Confidence interval estimates of efficiency for each port are reported. This paper provides useful insights into the application of a DEA bootstrap-based approach as a modeling tool to aid decision making in measuring port efficiency.
Engaging m-commerce adopters in India
Authors: Pandey Shweta , Chawla Deepak
Published: December 2018

Purpose

The purpose of this paper is to identify the impact of factors derived from the unified theory of user acceptance of technology (performance expectancy, effort expectancy, social influence, facilitating conditions, age, gender) and of those drawn from literature (perceived risk, perceived enjoyment and innovativeness) on the adoption of m-commerce in India. It also suggests implications of these for the consumer behavior theory practitioners and marketers.

Design/methodology/approach

Data were collected using an online survey from 321 respondents, split into two groups (high and low adoption level users) based on the usage scores of the four categories of m-commerce- location-based, transaction-based, entertainment and content delivery. Logistic regression technique was used to identify the prominent factors among the nine identified influencers to understand the differences between the two groups.

Findings

The findings of this paper are sample biasness, self-reported m-commerce adoption level, limited m-commerce categories and specific context.

Research limitations/implications

Except the two factors of performance expectancy and facilitating conditions, all other variables discriminate between low and high adoption levels of m-commerce services in India. Social influence, perceived enjoyment and innovativeness were the three main factors that were found to have the most significant impact on the discrimination levels of m-commerce service users in India. Further, it was found that women and the younger generation users of m-commerce showed a greater propensity for adopting m-commerce practices.

Practical implications

Marketers need to focus on key factors like social influence, perceived enjoyment, perceived risk and effort expectancy to persuade the young and innovative consumer target groups increase their adoption of m-commerce services.

Originality/value

This is the first study of its kind to explore factors that distinguish users with low and high levels of m-commerce adoption, by taking into consideration all four categories of m-commerce (transaction-based, content delivery, location-based and entertainment). In doing so, it highlights the need for marketers to focus on factors beyond facilitating conditions and performance expectancy, to enhance the adoption of m-commerce practices.