bluuebunny/crossref_metadata_2025 huggingface dataset:
Efficacy of neuroendoscopic and small-bone-window craniotomy microsurgery for hypertensive cerebral hemorrhage: a meta-analysis of Chinese RCT studies
Authors: Zhi Tianpeng , Wang Hang , Wei Xiangyang , Wei Zhengjun , Sun Hong-tao
Published: August 2024

Objective

To compare the clinical efficacy of neuroendoscopy and small-bone-window craniotomy microsurgery in the treatment of supratentorial hypertensive intracerebral hemorrhage.

Methods

A search was conducted for Chinese randomized controlled trials on neuroendoscopy and small-bone-window craniotomy microsurgery treatment of hypertensive intracerebral hemorrhage published before February 1, 2024, in PubMed, Embase, Web of Science, Cochrane Library, China National Knowledge Infrastructure, Wanfang Data, and China Science and Technology Journal Database. Meta-analysis was performed using Review Manager 5.4 software.

Results

We included 9 randomized controlled trials, with 391 cases in the neuroendoscopy group and 403 cases in the craniotomy group. The meta-analysis results showed that compared to the small-bone-window craniotomy group, the neuroendoscopy group had a higher rate of hematoma clearance (95% CI [6.65, 18.52], p < 0.00001), less intraoperative bleeding (95% CI [−294.83, −284.75], p < 0.00001), shorter operation time (95% CI [−138.65, −63.04], p < 0.00001), fewer days in the ICU (95% CI [−8.56, −4.04], p < 0.00001), lower rate of postoperative complications (95% CI [0.15, 0.50], p < 0.0001), lower NIHSS score at 3 months postoperatively (95% CI [−6.82, −5.36], p < 0.00001), and higher ADL score (95% CI [16.5, 20.07], p < 0.00001). All comparison results were statistically significant.

Conclusion

Compared with small-bone-window craniotomy microsurgery, neuroendoscopic surgery for episodic hypertensive cerebral hemorrhage resulted in a higher rate of hematoma clearance, less intraoperative bleeding, shorter operative time, fewer days in the ICU, a lower rate of postoperative complications and a lower 3-month postoperative NIHSS score, and a higher ADL score.
Hyperactive mTORC1 in striatum dysregulates dopamine receptor expression and odor preference behavior
Authors: Chen Lin , Saito Ryo , Noda-Narita Shoko , Kassai Hidetoshi , Aiba Atsu
Published: August 2024

Mechanistic target of rapamycin (mTOR) plays an important role in brain development and synaptic plasticity. Dysregulation of the mTOR pathway is observed in various human central nervous system diseases, including tuberous sclerosis complex, autism spectrum disorder (ASD), and neurodegenerative diseases, including Parkinson’s disease and Huntington’s disease. Numerous studies focused on the effects of hyperactivation of mTOR on cortical excitatory neurons, while only a few studies focused on inhibitory neurons. Here we generated transgenic mice in which mTORC1 signaling is hyperactivated in inhibitory neurons in the striatum, while cortical neurons left unaffected. The hyperactivation of mTORC1 signaling increased GABAergic inhibitory neurons in the striatum. The transgenic mice exhibited the upregulation of dopamine receptor D1 and the downregulation of dopamine receptor D2 in medium spiny neurons in the ventral striatum. Finally, the transgenic mice demonstrated impaired motor learning and dysregulated olfactory preference behavior, though the basic function of olfaction was preserved. These findings reveal that the mTORC1 signaling pathway plays an essential role in the development and function of the striatal inhibitory neurons and suggest the critical involvement of the mTORC1 pathway in the locomotor abnormalities in neurodegenerative diseases and the sensory defects in ASD.
Advances in pathogenesis and treatment of vascular endothelial injury-related diseases mediated by mitochondrial abnormality
Authors: Pang Boxian , Dong Guangtong , Pang Tieliang , Sun Xinyao , Liu Xin , Nie Yifeng , Chang Xing
Published: August 2024

Vascular endothelial cells, serving as a barrier between blood and the arterial wall, play a crucial role in the early stages of the development of atherosclerosis, cardiovascular diseases (CVDs), and Alzheimer’s disease (AD). Mitochondria, known as the powerhouses of the cell, are not only involved in energy production but also regulate key biological processes in vascular endothelial cells, including redox signaling, cellular aging, calcium homeostasis, angiogenesis, apoptosis, and inflammatory responses. The mitochondrial quality control (MQC) system is essential for maintaining mitochondrial homeostasis. Current research indicates that mitochondrial dysfunction is a significant driver of endothelial injury and CVDs. This article provides a comprehensive overview of the causes of endothelial injury in CVDs, ischemic stroke in cerebrovascular diseases, and AD, elucidating the roles and mechanisms of mitochondria in these conditions, and aims to develop more effective therapeutic strategies. Additionally, the article offers treatment strategies for cardiovascular and cerebrovascular diseases, including the use of clinical drugs, antioxidants, stem cell therapy, and specific polyphenols, providing new insights and methods for the clinical diagnosis and treatment of related vascular injuries to improve patient prognosis and quality of life. Future research should delve deeper into the molecular and mechanistic links between mitochondrial abnormalities and endothelial injury, and explore how to regulate mitochondrial function to prevent and treat CVDs.
HLH-30/TFEB modulates autophagy to improve proteostasis in Aβ transgenic Caenorhabditis elegans
Authors: Lin Hongru , Zhang Chen , Gao Yehui , Zhou Yi , Ma Botian , Jiang Jinyun , Long Xue , Yimamu Nuerziya , Zhong Kaixin , Li Yingzi , Cui Xianghuan , Wang Hongbing
Published: August 2024

Alzheimer’s disease (AD) is a complex neurodegenerative disease that affects elderly individuals, characterized by senile plaques formed by extracellular amyloid beta (Aβ). Autophagy dysfunction is a manifestation of protein homeostasis imbalance in patients with AD, but its relationship with Aβ remains unclear. Here, we showed that in Aβ transgenic Caenorhabditis elegans, Aβ activated the TOR pathway and reduced the nuclear entry of HLH-30, leading to autophagy dysfunction characterized by autophagosome accumulation. Then, utilizing RNA-seq, we investigated the regulatory mechanisms by which HLH-30 modulates autophagy in C. elegans. We found that HLH-30 elevated the transcript levels of v-ATPase and cathepsin, thus enhancing lysosomal activity. This led to an increase in autophagic flux, facilitating more pronounced degradation of Aβ. Moreover, HLH-30 reduced the level of ROS induction by Aβ and enhanced the antioxidant stress capacity of the worms through the gsto-1 gene. Additionally, we identified two HLH-30/TFEB activators, saikosaponin B2 and hypericin, that improved autophagic flux, thereby enhancing protein homeostasis in C. elegans. Overall, our findings suggested that HLH-30/TFEB plays a key role in modulating autophagy and can be considered a promising drug target for AD treatments.
Neurological activation during verbal fluency task and resting-state functional connectivity abnormalities in obsessive-compulsive disorder: a functional near-infrared spectroscopy study
Authors: Qiao Yongjun , Song Xiaohui , Yan Jin , Pan Wenxiu , Chia Chinhsuan , Zhao Dan , Niu Chuanxin M. , Xie Qing , Jin Haiyan
Published: August 2024

Objective

This study aims to investigate the activation of frontotemporal functional brain areas in patients with Obsessive-Compulsive Disorder (OCD) during a Verbal Fluency Task (VFT), and to compare their brain functional connectivity in a resting state with that of healthy controls. The goal is to deepen our understanding of the neuropathological mechanisms underlying OCD.

Methods

32 patients with OCD and 32 controls matched for age, gender, handedness, and years of education participated in this study, they were divided into OCD group and healthy comtrol group. We conducted VFT task tests and 10-minute resting state tests on both groups by using functional Near-Infrared Spectroscopy (fNIRS). The VFT was utilized to assess the activation (beta values) and the integral and centroid values of the frontal and bilateral temporal lobes, including brain areas BA9 and 46 (dorsolateral prefrontal cortex), BA10 (frontal pole), BA45 (inferior frontal gyrus), BA21 (middle temporal gyrus), and BA22 (superior temporal gyrus). We evaluated the functional connectivity levels of these areas during the resting state. Differences in these measures between OCD patients and healthy controls were analyzed using two-sample independent t-tests and non-parametric Mann-Whitney U tests.

Results

During VFT, OCD had smaller integral values(z=5.371, p<0.001; t=4.720, p<0.001), and larger centroid values(t=-2.281, p=0.026; z=-2.182, p=0.029) compared to healthy controls, along with a reduced number of activated channels detected by fNIRS. Additionally, activation values (β) in various functional brain areas, including BA9, BA46, BA10, BA45, BA21, and BA22, were significantly lower in the OCD group (all p< 0.01). In the resting state, notable disparities in functional connectivity were observed between the inferior frontal gyrus (IFG) and dorsolateral prefrontal cortex (DLPFC) in the OCD group, in comparison to the control group. Specifically, there was a significant increase in connectivity between the left IFG and right DLPFC, suggesting the presence of altered connectivity patterns in these areas.

Conclusions

The study highlights significant disparities in neural activation and functional connectivity between OCD patients and healthy controls during VFT. Specifically, reduced activation was noted in the frontal and bilateral temporal lobes of OCD patients, alongside alterations in resting-state functional connectivity between the IFG and DLPFC. These findings contribute to our understanding of the neurobiological underpinnings of OCD and may guide future therapeutic strategies.
On the development of a professional mandate by social workers in medical rehabilitation– key results from the SWIMMER Project
Authors: Knoop Tobias , Freymüller Nadja , Dettmers Stephan , Meyer-Feil Thorsten
Published: August 2024

Social work in the German rehabilitation sector is practiced with great variation and its interventions lack research evidence. The SWIMMER project aims to develop a program theory of social work in rehabilitation to explain this variation and to discuss possible conditions. The dealing with ethical dilemmas by social workers is one possible influence and the focus of this paper. The social workers’ practice was analyzed using the triple mandate, a German-Swiss concept that describes three possible, sometimes simultaneous directives without a concrete call to action from society, the client or the profession. This qualitative, case-comparative research project collected data from interviews with social workers and managers, participant observation and counseling sessions in ten German rehabilitation facilities. Social workers were confronted with all three mandates. They prioritized either the societal mandate or the client mandate. A consequence for social work practice was the limitation of options under social law (mandate by society). Social workers relied on their professional experience to reflect on the mandates. They used a variety of strategies when faced with conflicting mandates. The research project has succeeded in systematizing the orientations of social workers in goal conflicts. Further investigation on this topic on a broader basis would be beneficial.
Gender-Specific Implications of Foreign Direct Investments on Wage Dynamics in Croatia: A Comprehensive Management Perspective
Authors: Pirju Ionel Sergiu , Ioan Gina , Sirbu Carmen , Huru Dragoș , Săracu Alina Florentina
Published: August 2024

This study investigates the nuanced influence of Foreign Direct Investments (FDIs) on wage dynamics among Croatian workers, specifically examining the differential effects on male and female salaried employees. The authors employed statistical indicators and regression analysis, utilizing data from reputable sources, such as UNCTAD and the World Bank, to assess the dependency of wages on FDIs at time periods n and n − 1. By focusing on these temporal dynamics, the study aims to capture potential changes in the relationship between wages and FDIs, aligning with the total quality management (TQM) principle of systematic analysis. The findings highlighted the differential impact of FDIs on wage evolution for male and female workers, underscoring the importance of integrating gender-sensitive strategies within quality management frameworks.
Simultaneous Presence of Antibodies against Five Respiratory Pathogens in Unvaccinated Dairy Calves from South-Western Poland
Authors: Lachowicz-Wolak Agnieszka , Klimowicz-Bodys Małgorzata D. , Płoneczka-Janeczko Katarzyna , Bednarski Michał , Dyba Kamil , Knap Piotr , Rypuła Krzysztof
Published: August 2024

Bovine Respiratory Disease (BRD) poses a significant threat to cattle welfare worldwide, affecting their respiratory system and causing substantial economic losses. BRD is multifactorial in nature. This research aimed to investigate the serological profile of calves for the five main bovine respiratory pathogens. Serum samples were collected from dairy calves aged 7–12 months that had never been vaccinated against tested pathogens and had recently shown signs of BRD. A total of 4095 calves from 650 dairy herds located in south-western Poland were examined. The Commercial Indirect Respiratory ELISA Kit Multiplexed—Double well—BIO K 284/5 (Bio-X Diagnostics, Rochefort, Belgium) was used to determine the presence of antibodies against BVDV, BoAHV1, BRSV, BPIV3, and M. bovis. The presence of antibodies against at least one of the tested pathogens was found in 306 (47.08%) herds. The overall prevalence of antibodies was as follows: BoAHV1 21.54%, BVDV 32.0%, BRSV 34.15%, BPIV3 34.31%, and M. bovis 31.38%. The strongest correlation was between BRSV antibodies positive sera and BPIV3 antibodies positive sera. Among the five pathogens tested, antibodies to BVDV, BRSV, BPIV3, and M. bovis were most commonly detected simultaneously. The results of this study indicate the need for preventive measures against these pathogens in the studied region.
Comparative Study of the Healing Process of Disbudding Wounds in Calves Using Bepanthene® or an Antibiotic Spray
Authors: Martins Gabriela , Stilwell George
Published: August 2024

The process of disbudding female calves is a common procedure in many dairy farms, avoiding injuries caused by horns and reducing feed bunk space requirements. The most common method for disbudding calves is by the use of a cautery iron, responsible for destroying the horn-generating tissue. After the procedure, wounds may be treated with an antibiotic-based spray. Nowadays, antimicrobial resistance is a worldwide concern in both human and veterinary medicine, highlighting the need to invest in the monitoring of antimicrobial use and in the development of alternative treatments in favour of One Health. The goal of this study is to promote a reduction in the use of antibiotics in farm animals by investigating an alternative treatment for disbudding wounds. Bepanthene® (dexpanthenol, a derivative of pantothenic acid, a component of the B vitamin complex) is a plausible option, since it is widely used in human medicine for the treatment of skin irritations and burns. The comparison of the healing process of disbudding wounds treated with Bepanthene® or a chlortetracycline-based spray was achieved through the presentation of a randomly-ordered sequence of images of the lesions to a panel of convenience-selected and blinded-to-treatment evaluators, composed of seven veterinarian practitioners, five veterinary medicine students, and five human medical field nurses. In order to classify the lesions, the panel applied an adapted format of a validated healing scale (Bates–Jensen Wound Assessment Tool), incorporating seven parameters of evaluation, culminating in the values used for statistical analyses. In the practitioners’ evaluation, a statistically significant effect for the factors of time and treatment in favour of Bepanthene® was found for the parameters “Edges”, “Necrotic Tissue Type”, and “Skin Colour Surrounding Wound”, indicating that Bepanthene® is superior to the spray when considering these parameters of healing. The assessment by the veterinary students showed a significant effect for the factors of time and treatment for the parameters “Necrotic Tissue Type”, in favour of the Bepanthene®, and “Granulation Tissue”, in favour of the antibiotic spray, demonstrating no clear benefit for either treatment. Lastly, the evaluation performed by nurses showed a significant effect for the factors of time and treatment, in favour of the Bepanthene®, for the parameters “Necrotic Tissue Type” and “Skin Colour Surrounding Wound”, leading to the conclusion that Bepanthene® is associated with better and faster healing when compared to the spray. Overall, these findings lead us to suggest that Bepanthene® presents a better healing index compared to a chlortetracycline-based spray, allowing it to be safely used as a substitute to an antimicrobial agent.
Variation in Antibiotic Prescription in High-Risk Febrile Neutropenia in Portuguese Hospitals
Authors: Freitas Marta , Andrade Paulo , Pinto Ricardo , Trigo Fernanda , Azevedo Ana , Almeida Francisco
Published: August 2024

Introduction: Febrile neutropenia (FN) is a potentially severe entity, particularly in hemato-oncologic patients who have higher incidence of colonization with multidrug-resistant bacteria. Discrepancies among guidelines contribute to divergence in antimicrobial practices. Our objective was to assess the variation of practices in antimicrobial therapy in high-risk FN among Portuguese hematologists. Methods: We conducted a cross-sectional study through the implementation of an online survey, open to all clinical hematologists in the country. To characterize practice patterns regarding critical elements in FN management, three clinical vignettes were designed to describe typical situations where narrow-spectrum empiric antibiotics (vignette 1), short-course therapy (vignette 2) and de-escalation (vignette 3) could be performed. The remaining questions characterized clinical experience, department size, and differentiation and decision-making process regarding FN antibiotic therapy. Results: The survey yielded 31 responses from 11 hospitals across four regions. All respondents opted for empiric narrow-spectrum antibiotics, 22.6% opted for short-course therapy (mostly senior specialists from larger settings) and 35.5% for de-escalation (mostly young specialists). Availability of an FN protocol seemed to favor both approaches. These findings should be complemented by qualitative assessments of barriers to best practices and should support the need for interventions to improve antibiotic use in febrile neutropenia.
Priming of Exogenous Salicylic Acid under Field Conditions Enhances Crop Yield through Resistance to Magnaporthe oryzae by Modulating Phytohormones and Antioxidant Enzymes
Authors: Thepbandit Wannaporn , Srisuwan Anake , Athinuwat Dusit
Published: August 2024

This study explores the impact of exogenous salicylic acid (SA) alongside conventional treatment by farmers providing positive (Mancozeb 80 % WP) and negative (water) controls on rice plants (Oryza sativa L.), focusing on antioxidant enzyme activities, phytohormone levels, disease resistance, and yield components under greenhouse and field conditions. In greenhouse assays, SA application significantly enhanced the activities of peroxidase (POX), polyphenol oxidase (PPO), catalase (CAT), and superoxide dismutase (SOD) within 12–24 h post-inoculation (hpi) with Magnaporthe oryzae. Additionally, SA-treated plants showed higher levels of endogenous SA and indole-3-acetic acid (IAA) within 24 hpi compared to the controls. In terms of disease resistance, SA-treated plants exhibited a reduced severity of rice blast under greenhouse conditions, with a significant decrease in disease symptoms compared to negative control treatment. The field study was extended over three consecutive crop seasons during 2021–2023, further examining the efficacy of SA in regular agricultural practice settings. The SA treatment consistently led to a reduction in rice blast disease severity across all three seasons. Yield-related parameters such as plant height, the number of tillers and panicles per hill, grains per panicle, and 1000-grain weight all showed improvements under SA treatment compared to both positive and negative control treatments. Specifically, SA-treated plants yielded higher grain outputs in all three crop seasons, underscoring the potential of SA as a growth enhancer and as a protective agent against rice blast disease under both controlled and field conditions. These findings state the broad-spectrum benefits of SA application in rice cultivation, highlighting its role not only in bolstering plant defense mechanisms and growth under greenhouse conditions but also in enhancing yield and disease resistance in field settings across multiple crop cycles. This research presents valuable insights into the practical applications of SA in improving rice plant resilience and productivity, offering a promising approach for sustainable agriculture practices.
Phytochemical-Based Nanoantioxidants Stabilized with Polyvinylpyrrolidone for Enhanced Antibacterial, Antioxidant, and Anti-Inflammatory Activities
Authors: Oh Hyeryeon , Lee Jin Sil , Park Hyojung , Son Panmo , Jeon Byoung Seung , Lee Sang Soo , Sung Daekyung , Lim Jong-Min , Choi Won Il
Published: August 2024

Despite the inhibitory effect of phytoncide (Pht) on food-borne pathogenic bacterial growth, the hydrophobic nature and susceptibility to biodegradation under physiological conditions limits its applications. Here, we developed Pht-loaded polyvinylpyrrolidone (PVP) micelles (Pht@PVP MC) via micelle packing. Pht was solubilized using different types of PVP as micellar vehicles. The as-prepared Pht@PVP MCs were characterized using dynamic light scattering and transmission electron microscopy. The sizes of the Pht@PVP MCs were controlled from 301 ± 51 to 80 ± 3 nm by adjusting the PVP content. The polydispersity index of Pht@PVP MC was between 0.21 ± 0.03 and 0.16 ± 0.04, indicating homogeneous size. A colony-counting method was employed to evaluate the improvement in antibacterial activity after Pht encapsulation in PVP micelles. The reactive oxygen species (ROS)-scavenging activity and anti-inflammatory efficacy of Pht@PVP MC were analyzed in a concentration range of 10–100 μg/mL by evaluating in vitro ROS and nitric oxide levels using DCFDA and Griess reagents. PVP with both hydrophobic and hydrophilic moieties improved the aqueous solubility of Pht and stabilized it via steric hindrance. Higher-molecular-weight PVP at higher concentrations resulted in a smaller hydrodynamic diameter of Pht@PVP MC with uniform size distribution. The spherical Pht@PVP MC maintained its size and polydispersity index in a biological buffer for 2 weeks. Pht@PVP MC exhibited enhanced antibacterial activity compared to bare Pht. The growth of Staphylococcus aureus was effectively inhibited by Pht@PVP MC treatment. Furthermore, biocompatible Pht@PVP MC exhibited dose-dependent antioxidant and anti-inflammatory activities in vitro. Overall, Pht@PVP MC is an effective alternative to synthetic antibacterial, antioxidant, and anti-inflammatory chemicals.
Sodium Houttuybonate Promotes the Browning of White Adipose Tissue by Inhibiting Ferroptosis via the AMPK-NRF2-HO1 Pathway
Authors: Liu Wenhui , Zou Huren , You Danming , Zhang Huijie , Xu Lingling
Published: August 2024

The rising prevalence of obesity has resulted in an increased demand for innovative and effective treatment strategies. Houttuynia cordata Thunb. (H. cordata) has demonstrated promising potential in preventing obesity. However, the mechanism underlying the anti-obesity effects of H. cordata and its bioactive component, sodium houttuybonate (SH), remains unclear. Our study reveals that SH treatment promotes the browning of inguinal white adipose tissue (iWAT) and prevents the obesity induced by a high-fat diet. SH significantly mitigates ferroptosis by upregulating glutathione peroxidase 4 (Gpx4) and decreasing malondialdehyde (MDA) levels, while also enhancing superoxide dismutase (SOD) levels. Furthermore, SH promotes the phosphorylation of AMP-activated protein kinase (AMPK), which subsequently increases the expression of nuclear factor erythroid 2-related factor 2 (NRF2) and heme oxygenase-1 (HO-1) in the iWAT. However, the effects of SH were attenuated by ML385, an Nrf2 inhibitor. Collectively, our findings suggest that SH induces iWAT browning and prevents diet-induced obesity primarily through the AMPK/NRF2/HO-1 pathway by inhibiting ferroptosis.
Oxidative State in Cutaneous Melanoma Progression: A Question of Balance
Authors: Benedusi Mascia , Lee Heaji , Lim Yunsook , Valacchi Giuseppe
Published: August 2024

Reactive oxygen species (ROS) are highly bioactive molecules involved not only in tissue physiology but also in the development of different human conditions, including premature aging, cardiovascular pathologies, neurological and neurodegenerative disorders, inflammatory diseases, and cancer. Among the different human tumors, cutaneous melanoma, the most aggressive and lethal form of skin cancer, is undoubtedly one of the most well-known “ROS-driven tumor”, of which one of the main causes is represented by ultraviolet (UV) rays’ exposure. Although the role of excessive ROS production in melanoma development in pro-tumorigenic cell fate is now well established, little is known about its contribution to the progression of the melanoma metastatic process. Increasing evidence suggests a dual role of ROS in melanoma progression: excessive ROS production may enhance cellular growth and promote therapeutic resistance, but at the same time, it can also have cytotoxic effects on cancer cells, inducing their apoptosis. In this context, the aim of the present work was to focus on the relationship between cell redox state and the signaling pathways directly involved in the metastatic processes. In addition, oxidative or antioxidant therapeutic strategies for metastatic melanoma were also reviewed and discussed.
Valorizing Tea Waste: Green Synthesis of Iron Nanoparticles for Efficient Dye Removal from Water
Authors: Rodríguez-Rasero Cristina , Alexandre-Franco María F. , Fernández-González Carmen , Montes-Jiménez Vicente , Cuerda-Correa Eduardo M.
Published: August 2024

This study explores the valorization of tea leaf waste by extracting polyphenols through reflux extraction, subsequently using them to synthesize zero-valent iron nanoparticles (nZVI). The in situ generated nanoparticles, when combined with fixed amounts of hydrogen peroxide, facilitated the removal of various dyes (methylene blue, methyl orange, and orange G) via a hetero-catalytic Fenton process. The iron nanoparticles were thoroughly characterized by gas adsorption of N2 at 77 K, scanning electron microscopy (SEM), Transmission Electron Microscopy (TEM), FT-IR spectroscopy, X-ray diffraction (XRD), and thermal analysis, including thermogravimetric analysis (TG) and temperature-programmed reduction (TPR). A statistical design of experiments and response surface methodology were employed to analyze the influence of polyphenol, Fe(III), and H2O2 concentrations on dye removal efficiency. The results demonstrated that optimizing the operational conditions could achieve 100% dye removal efficiency. This study highlights the potential of nZVI synthesized through eco-friendly methods as a promising solution for water decontamination involving diverse model dyes, thus contributing to sustainable waste management and environmental protection.
Redox Homeostasis, Gut Microbiota, and Epigenetics in Neurodegenerative Diseases: A Systematic Review
Authors: Munteanu Constantin , Galaction Anca Irina , Turnea Marius , Blendea Corneliu Dan , Rotariu Mariana , Poștaru Mădălina
Published: August 2024

Neurodegenerative diseases encompass a spectrum of disorders marked by the progressive degeneration of the structure and function of the nervous system. These conditions, including Parkinson’s disease (PD), Alzheimer’s disease (AD), Huntington’s disease (HD), Amyotrophic lateral sclerosis (ALS), and Multiple sclerosis (MS), often lead to severe cognitive and motor deficits. A critical component of neurodegenerative disease pathologies is the imbalance between pro-oxidant and antioxidant mechanisms, culminating in oxidative stress. The brain’s high oxygen consumption and lipid-rich environment make it particularly vulnerable to oxidative damage. Pro-oxidants such as reactive nitrogen species (RNS) and reactive oxygen species (ROS) are continuously generated during normal metabolism, counteracted by enzymatic and non-enzymatic antioxidant defenses. In neurodegenerative diseases, this balance is disrupted, leading to neuronal damage. This systematic review explores the roles of oxidative stress, gut microbiota, and epigenetic modifications in neurodegenerative diseases, aiming to elucidate the interplay between these factors and identify potential therapeutic strategies. We conducted a comprehensive search of articles published in 2024 across major databases, focusing on studies examining the relationships between redox homeostasis, gut microbiota, and epigenetic changes in neurodegeneration. A total of 161 studies were included, comprising clinical trials, observational studies, and experimental research. Our findings reveal that oxidative stress plays a central role in the pathogenesis of neurodegenerative diseases, with gut microbiota composition and epigenetic modifications significantly influencing redox balance. Specific bacterial taxa and epigenetic markers were identified as potential modulators of oxidative stress, suggesting novel avenues for therapeutic intervention. Moreover, recent evidence from human and animal studies supports the emerging concept of targeting redox homeostasis through microbiota and epigenetic therapies. Future research should focus on validating these targets in clinical settings and exploring the potential for personalized medicine strategies based on individual microbiota and epigenetic profiles.
Antioxidant Capacity, Enzyme Activities Related to Energy Metabolism, and Transcriptome Analysis of Crassostrea hongkongensis Exposed to Hypoxia
Authors: He Pingping , Li Wei , Wei Pinyuan , Jiang Linyuan , Guan Junliang , Ma Yuan , Zhang Li , Chen Yongxian , Zheng Yusi , Zhang Xingzhi , Peng Jinxia
Published: August 2024

Crassostrea hongkongensis (C. hongkongensis) is one of the three most commonly cultivated oyster species in China. Seasonal hypoxia is one of the most serious threats to its metabolism, reproductive behavior, and survival. To investigate the effects of hypoxia stress on the antioxidant capacity and energy metabolism of C. hongkongensis, the total antioxidant capacity (T-AOC), glycogen content, and enzyme activities (phosphofructokinase, PFK; pyruvate kinase, PK; phosphoenolpyruvate carboxykinase, PEPCK) of oysters were determined under normoxic (DO 6 ± 0.2 mg/L) and hypoxic (DO 1.5 mg/L) conditions at 0 h, 6 h, 48 h, and 72 h. We also determined the T-AOC, glycogen content, and enzyme activities of oysters under reoxygenation (recovered to normoxia for 24 h). To further examine the potential molecular regulatory mechanism of hypoxic adaptation, a transcriptome analysis was conducted on the gill of C. hongkongensis under normoxia (N, 72 h), hypoxia (H, 72 h), and reoxygenation (R). After being exposed to hypoxia for 6 h, the T-AOC, glycogen content, and enzyme activities of PK, PFK, and PEPCK in C. hongkongensis were significantly decreased. However, after prolonging the duration of hypoxia exposure for 72 h, the T-AOC, glycogen content, and enzyme activities increased compared to that of 48 h. After 24 h reoxygenation, the T-AOC, glycogen content, and enzyme activity of PK and PFK returned to close to initial levels. In addition, a transcriptome analysis discovered 6097 novel genes by mapping the C. hongkongensis genome with the clean reads. In total, 352 differentially expressed genes (DEGs) were identified in the H vs. N comparison group (235 upregulated and 117 downregulated genes). After recovery to normoxia, 292 DEGs (134 upregulated and 158 downregulated genes) were identified in the R vs. N comparison group, and 632 DEGs were identified (253 upregulated and 379 downregulated genes) in the R vs. H comparison group. The DEGs included some hypoxia-tolerant genes, such as phosphoenolpyruvate carboxykinase (PEPCK), mitochondrial (AOX), tyramine beta-hydroxylase (TBH), superoxide dismutase (SOD), glutathione S-transferase (GST), and egl nine homolog 1 isoform X2 (EGLN1). Additionally, DEGs were significantly enriched in the KEGG pathways that are involved in hypoxia tolerance, including the metabolism of xenobiotics by cytochrome P450 pathways and the HIF-1 signaling pathway. Then, we selected the five hypoxic-tolerant candidate DEGs for real-time quantitative polymerase chain reaction (RT-qPCR) validation, and the results were consistent with the transcriptome sequencing data. These discoveries have increased our understanding of hypoxia tolerance, recovery ability after reoxygenation, and molecular mechanisms governing the responses to hypoxia in C. hongkongensis.
Deep Eutectic Solvent Pretreatment and Green Separation of Lignocellulose
Authors: Yao Zhengyuan , Chong Gunhean , Guo Haixin
Published: August 2024

Plant-based waste biomass with lignocellulose as an important component is produced in large quantities worldwide every year. The components of lignocellulose that typically exhibit high utilization value include cellulose and hemicellulose, as well as pentoses and hexoses derived from their hydrolysis. As a pretreatment for the hydrolysis process, delignification is a pivotal step to enhance cellulose/hemicellulose accessibility and achieve high yields of fermentable sugars. Additionally, deep eutectic solvents (DESs) are the most widely used solvents for delignification during biomass fractionation due to their clean and environmentally friendly attributes. DESs dissolve lignin by inducing a large amount of β-O-4 bond cleavage and partial carbon–carbon bond cleavage, retaining cellulose in the solid residue, while most of the hemicellulose is hydrolyzed in DES pretreatment. This article provides a comprehensive review of the influence of DESs in the lignocellulose separation process. Key factors such as lignin removal rate, sugar conversion rate, and product chemical structure are critically reviewed to assess the feasibility of employing DESs for lignocellulose separation.
A Nonlinear Damper with Dynamic Load and an Elastic Slit Membrane: Modeling and Interaction Analysis
Authors: Sadeghian Mostafa , Pilkauskas Kestutis , Palevicius Paulius , Ragulskiene Jurate , Janusas Giedrius , Dorosevas Viktoras , Palevicius Arvydas
Published: August 2024

This article presents research into the feasibility of applying a nonlinear damper of a new conceptual structure. The key component of the damper is a circular membrane with slits that can move in a cylinder filled with viscous fluid. When an external load is applied to the damper, the membrane deforms, opening the slits. The flow of viscous fluid through the slits generates a damping force. The phenomenological model of the damper is based on the notion that the slit membrane moves according to the fundamental axisymmetric vibration mode of a circular membrane. The slit membrane blocks the entire radius of the pipe in the state of equilibrium when all slits are closed. As the membrane moves, the opening area of the slits varies depending on its deformation. This gives a nonlinear damping characteristic. The damping constant depends on the input displacement and velocity, which is the reason for the nonlinearity of the damping characteristic. From the phenomenological model, the nonlinear characteristic of the drag force is obtained. The performance of the damper is simulated using a mass–spring–damper system. Two cases of harmonic excitation and impulse excitation are analyzed. The results show that, using the slit membrane damper, the suppression of dynamic loads is more effective compared to a conventional linear damper.
Leveraging LLMs for Efficient Topic Reviews
Authors: Gana Bady , Leiva-Araos Andrés , Allende-Cid Héctor , García José
Published: August 2024

This paper presents the topic review (TR), a novel semi-automatic framework designed to enhance the efficiency and accuracy of literature reviews. By leveraging the capabilities of large language models (LLMs), TR addresses the inefficiencies and error-proneness of traditional review methods, especially in rapidly evolving fields. The framework significantly improves literature review processes by integrating advanced text mining and machine learning techniques. Through a case study approach, TR offers a step-by-step methodology that begins with query generation and refinement, followed by semi-automated text mining to identify relevant articles. LLMs are then employed to extract and categorize key themes and concepts, facilitating an in-depth literature analysis. This approach demonstrates the transformative potential of natural language processing in literature reviews. With an average similarity of 69.56% between generated and indexed keywords, TR effectively manages the growing volume of scientific publications, providing researchers with robust strategies for complex text synthesis and advancing knowledge in various domains. An expert analysis highlights a positive Fleiss’ Kappa score, underscoring the significance and interpretability of the results.
Nanoscale Surface Roughness Effects on Photoluminescence and Resonant Raman Scattering of Cadmium Telluride
Authors: Medel-Ruiz Carlos Israel , Chiu Roger , Sevilla-Escoboza Jesús Ricardo , Casillas-Rodríguez Francisco Javier
Published: August 2024

Surface roughness significantly affects light reflection and absorption, which is crucial for light–matter interaction studies and material characterization. This work examines how nanoscale surface roughness affects the electronic states and vibrational properties of cadmium telluride (CdTe) single crystals, using photoluminescence (PL) and resonant Raman scattering (RRS) spectroscopies. We have evaluated the surface roughness across various sample regions as the root-mean-square (RMS) value measured by atomic force microscopy (AFM). At room temperature, increasing RMS correlated with changes in PL intensity and peak width, as well as enhanced second-order longitudinal optical (2LO) phonon mode intensity. Fitting the PL and RRS spectra with Gaussian and Lorentzian functions, respectively, allowed us to explain the relationship between surface morphology and the observed spectral changes. Our findings demonstrate that surface roughness is a critical parameter influencing the surface states and vibrational properties of CdTe, with implications for the performance of CdTe-based devices.
Assessing Evapotranspiration Models for Regional Implementation in the Mediterranean: A Comparative Analysis of STEPS, TSEB, and SCOPE with Global Datasets
Authors: Unnisa Zaib , Govind Ajit , Prikaziuk Egor , Van der Tol Christiaan , Lasserre Bruno , Burchard-Levine Vicente , Marchetti Marco
Published: August 2024

Accurate evapotranspiration (ET) estimation is crucial for sustainable water management in the diverse and water-scarce Mediterranean region. This study compares three prominent models (Simulator of Terrestrial Ecohydrological Processes and Systems (STEPS), Soil-Canopy-Observation of Photosynthesis and Energy fluxes (SCOPE), and Two-Source Energy Balance (TSEB)) with established global datasets (Moderate Resolution Imaging Spectroradiometer 8-day global terrestrial product (MOD16A2), Global Land Evaporation Amsterdam Model (GLEAM), and TerraClimate) at multiple spatial and temporal scales and validates model outcomes with eddy covariance based ground measurements. Insufficient ground-based observations limit comprehensive model validation in the eastern Mediterranean part (Turkey and Balkans). The results reveal significant discrepancies among models and datasets, highlighting the challenges of capturing ET variability in this complex region. Differences are attributed to variations in ecosystem type, energy balance calculations, and water availability constraints. Ground validation shows that STEPS performs well in some French and Italian forests and crops sites but struggles with seasonal ET patterns in some locations. SCOPE mostly overestimates ET due to detailed radiation flux calculations and lacks accurate water limitation representation. TSEB faces challenges in capturing ET variations across different ecosystems at a coarser 10 km resolution. No single model and global dataset accurately represent ET across the entire region. Model performance varies by region and ecosystem. As GLEAM and TSEB excel in semi-arid Savannahs, STEPS and SCOPE are better in grasslands, croplands, and forests in few locations (5 out of 18 sites) which indicates these models need calibration for other locations and ecosystem types. Thus, a region-specific model calibration and validation, sensitive to extremely humid and arid conditions can improve ET estimation across the diverse Mediterranean region.
Portable VR Welding Simulator
Authors: Michalak Dariusz , Rozmus Magdalena , Tokarczyk Jarosław , Szewerda Kamil
Published: August 2024

In many industries, there is a continuous high demand for skilled welders. Practical training in welding is cost- and time-intensive. To reduce this problem, VR welding simulators have been developed in recent years. They vary in terms of portability, hardware and software components, and functionalities. In this paper, a VR simulator to support practical training in MIG/MAG welding, as a highly portable and affordable solution, is presented. Its only hardware components are an off-the-shelf mobile VR set, a welding torch, and welding coupons that are manufactured using the FDM 3D printing method. The software part is accessed and used via an Internet browser. An important feature of the simulator is also the possibility to differ immersion in the working environment while carrying out virtual welding, which makes the solution also usable for users prone to cybersickness. The VR welding simulator was refined based on feedback obtained during pilot tests. The test participants found it a useful aid for welders’ training, which justifies further work on its development and integration into the teaching of welding in educational and training units.
Art Notions in the Age of (Mis)anthropic AI
Authors: Grba Dejan
Published: August 2024

In this paper, I take the cultural effects of generative artificial intelligence (generative AI) as a context for examining a broader perspective of AI’s impact on contemporary art notions. After the introductory overview of generative AI, I summarize the distinct but often confused aspects of art notions and review the principal lines in which AI influences them: the strategic normalization of AI through art, the representation of AI art in the artworld, academia, and AI research, and the mutual permeability of art and kitsch in the digital culture. I connect these notional factors with the conceptual and ideological substrate of the computer science and AI industry, which blends the machinic agency fetishism, the equalization of computers and humans, the sociotechnical blindness, and cyberlibertarianism. The overtones of alienation, sociopathy, and misanthropy in the disparate but somehow coalescing philosophical premises, technical ideas, and political views in this substrate remain underexposed in AI studies so, in the closing discussion, I outline their manifestations in generative AI and introduce several viewpoints for a further critique of AI’s cultural zeitgeist. They add a touch of skepticism to pondering how technological trends change our understanding of art and in which directions they stir its social, economic, and political roles.
Hybrid Fuzzy C-Means Clustering Algorithm, Improving Solution Quality and Reducing Computational Complexity
Authors: Pérez-Ortega Joaquín , Moreno-Calderón Carlos Fernando , Roblero-Aguilar Sandra Silvia , Almanza-Ortega Nelva Nely , Frausto-Solís Juan , Pazos-Rangel Rodolfo , Martínez-Rebollar Alicia
Published: August 2024

Fuzzy C-Means is a clustering algorithm widely used in many applications. However, its computational complexity is very large, which prevents its use for large problem instances. Therefore, a hybrid improvement is proposed for the algorithm, which considerably reduces the number of iterations and, in many cases, improves the solution quality, expressed as the value of the objective function. This improvement integrates two heuristics, one in the initialization phase and the other in the convergence phase or the convergence criterion. This improvement was called HPFCM. A set of experiments was designed to validate this proposal; to this end, four sets of real data were solved from a prestigious repository. The solutions obtained by HPFCM were compared against those of the Fuzzy C-Means algorithm. In the best case, reductions of an average of 97.65% in the number of required iterations and an improvement in quality solution of 82.42% were observed when solving the SPAM dataset. Finally, we consider that the proposed heuristics may inspire improvements in other specific purpose variants of Fuzzy C-Means.
Aberrant Flexibility of Dynamic Brain Network in Patients with Autism Spectrum Disorder
Authors: Zhang Hui , Peng Dehong , Tang Shixiong , Bi Anyao , Long Yicheng
Published: August 2024

Autism spectrum disorder (ASD) is a collection of neurodevelopmental disorders whose pathobiology remains elusive. This study aimed to investigate the possible neural mechanisms underlying ASD using a dynamic brain network model and a relatively large-sample, multi-site dataset. Resting-state functional magnetic resonance imaging data were acquired from 208 ASD patients and 227 typical development (TD) controls, who were drawn from the multi-site Autism Brain Imaging Data Exchange (ABIDE) database. Brain network flexibilities were estimated and compared between the ASD and TD groups at both global and local levels, after adjusting for sex, age, head motion, and site effects. The results revealed significantly increased brain network flexibilities (indicating a decreased stability) at the global level, as well as at the local level within the default mode and sensorimotor areas in ASD patients than TD participants. Additionally, significant ASD-related decreases in flexibilities were also observed in several occipital regions at the nodal level. Most of these changes were significantly correlated with the Autism Diagnostic Observation Schedule (ADOS) total score in the entire sample. These results suggested that ASD is characterized by significant changes in temporal stabilities of the functional brain network, which can further strengthen our understanding of the pathobiology of ASD.