bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of Arrhenius Activation Energy and Binary Chemical Reaction on Convective Flow of a Nanofluid over Frustum of a Cone with Convective Boundary Condition
Authors: Chetteti RamReddy , Rao Chukka Venkata
Published: June 2017

In this article, we investigate the effects of Arrhenius activation energy with binary chemical reaction and convective boundary condition on natural convective flow over vertical frustum of a cone in a Buongiorno nanofluid under the presence of thermal radiation. The zero nanoparticle flux condition is used at the surface of frustum of a cone rather than the uniform wall condition to execute physically applicable results. For this complex flow model, a suitable non-similarity transformations are used initially and then Bivariate pseudo-spectral local linearisation method is used to solve the non-similar, coupled partial differential equations. Further, the convergence test and error analysis are conducted to verify the accuracy of numerical method. The effects of flow influenced parameters on the non-dimensional velocity, temperature, nanoparticle volume fraction and regular concentration profiles as well as on the skin friction, heat transfer rate, nanoparticle and regular mass transfer rates are analyzed.
Modification of Konjac Glucomannan by Reduced-Pressure Radio-Frequency Air Plasma
Authors: Wang Shi-Qing , Huang Guo-Qing , Du Yan-Li , Xiao Jun-Xia
Published: June 2017

The potential of reduced-pressure radio-frequency air plasma (RFAP) in the modification of konjac glucomannan (KGM) was investigated. KGM film was exposed to 100 W RFAP for 50 s, 100 s, 150 s, 200 s, and 250 s, ground, and then subjected to various characterizations. Fourier Transform Infrared Spectroscopy (FTIR) revealed that RFAP treatment increased the content of –OH groups in KGM, with the lowest and highest rise occurring at the exposure durations 150 s and 250 s, respectively. RFAP radiation decreased the solubility of KGM at certain exposure durations, but slightly increased its thermal stability. Exposure to RFAP for 150 s and 250 s increased the hardness of the resultant KGM gel, but decreased the viscosity and elasticity of the KGM solution in a duration-dependent manner. Scanning Electron Microscope (SEM) observation revealed that RFAP treatment led to rougher surfaces and XRD (X-Ray Diffraction) analysis indicated the destroyed crystallinity of KGM. Hence, RFAP has potential application in the modification of KGM.
Habits as Signs: Some Reflections on the Ethical Shape of Christian Community
Authors: Goroncy Jason
Published: June 2017

The Christian faith is concerned not simply with what we might call “ideas” or “beliefs” but is also profoundly attentive to the question “How then shall we live?” This essay suggests ten particular habits and convictions that undergird, make judgements about, and give shape to Christian faith communities committed to pursuing such a question in ways that embody theological integrity.
Variation, contact, and change in language varieties in Yul shul (northern Khams)
Authors: Gelek Konchok
Published: June 2017

This article describes Tibetan dialect standardization due to rural-urban migration and participation in formal schooling in Yul shul Tibetan Autonomous Prefecture. As socio-economic development of China’s Tibetan regions accelerates in the twenty-first century, rural people travel and relocate to regional urban centers more frequently, and are thus exposed to a variety of dialects. Meanwhile, participation in formal state-sponsored schooling is also increasing. Both these phenomena create new sociolinguistic environments in which regiolect standardization is occurring. To investigate this situation, I conducted a survey of one middle school class and one associate diploma class at two different educational institutions in Khams, in order to investigate how students’ accents shift to standard regional regiolects, such as Sga ba regiolect in Yul shul.
An “Egyptianising” Underworld Judging an Assyrian Prince? New Perspectives on VAT 10057
Authors: Loktionov Alexandre Alexandrovich
Published: June 2017

This article makes the case for an Egyptian connection in the Neo-Assyrian tablet VAT 10057, commonly known as the Underworld Vision of an Assyrian Prince. It opens with a discussion of past work on this tablet, a synopsis of the text, and a survey of the evidence for Egyptian people and culture in the Neo-Assyrian Empire. It then proceeds to analyse specific lines of the composition which may reveal signs of what is termed “Egyptianising” influence. One description in particular, featuring a god standing atop a crocodile, is highlighted as especially convincing on the basis of a very close match with contemporary Egyptian iconography of the god Horus. In the light of this principal evidence, other possible but less definitive examples are put forward. The article also discusses the nature of the “Egyptianising” elements, assessing the possibilities of both purely descriptive and conceptual connections with Egyptian culture, and what this might indicate about the people behind the text. The “Egyptianising” elements are also located in the broader context of the composition, and their place in a complex Mesopotamian text also incorporating some Elamite elements is considered. Overall, the article aims to demonstrate that some sort of Egyptian connection was present, although it concedes that its scale and nature are perhaps impossible to gauge. It is hoped that this piece will encourage other scholars to pursue connections between Egypt and Assyria with renewed vigour, demonstrating that textual analysis may prove fruitful in this area.
Inflation in a Fully-Euroised Economy: Could Inflation Differentials Threaten Competitiveness?
Authors: Mitrović-Mijatović Marijana , Ivanović Maja
Published: June 2017

This paper analyses inflation in Montenegro, a country which uses euro outside the euro area, and investigates the factors which contribute to price differentials in Montenegro relative to the euro area. Furthermore, the paper examines whether changes in the real effective exchange rates, which in Montenegro’s case follow the path of price differentials, may have any influence on country’s competitiveness.
Tensor based approach to the numerical treatment of the
parameter estimation problems in mathematical immunology
Authors: Zheltkova Valeriya V. , Zheltkov Dmitry A. , Grossman Zvi , Bocharov Gennady A. , Tyrtyshnikov Eugene E.
Published: June 2017

The development of efficient computational tools for data assimilation and analysis using multi-parameter models is one of the major issues in systems immunology. The mathematical description of the immune processes across different scales calls for the development of multiscale models characterized by a high dimensionality of the state space and a large number of parameters. In this study we consider a standard parameter estimation problem for two models, formulated as ODEs systems: the model of HIV infection and BrdU-labeled cell division model. The data fitting is formulated as global optimization of variants of least squares objective function. A new computational method based on Tensor Train (TT) decomposition is applied to solve the formulated problem. The idea of proposed method is to extract the tensor structure of the optimized functional and use it for optimization. The method demonstrated a better performance in comparison with some other broadly used global optimization techniques.
A Semantic and Pragmatic Account of the -te-ar Construction in Japanese
Authors: Toratani Kiyoko
Published: June 2017

This study examines the conditions governing the distribution of the nominative-marked argument and the verb in the resultative -te-ar construction (e.g. E ga kake-te-ar-u ‘A picture has been hung (there)’). Much attention has been paid to agency and its associated character to elucidate the nature of this construction (e.g. Matsumoto 1990). The current analysis argues for a need to consider both semantic and pragmatic conditions. On the basis of Van Valin and LaPolla (1997), this study offers a lexical decompositional analysis of the verbs that can enter into the -te-ar construction. It argues that the construction requires the verb to possess an activity and a change-of-state component in its logical structure (LS), corroborating and expanding on Hasegawa (1996). The notion of coercion is drawn upon to explain why a verb that lacks the change-of-state component in its LS can be combined with -te-ar in some contexts. Further, the notion of objectivity (Kuno 1972) is drawn upon to account for infelicities arising when the sentence functions as presentational.
Verb movement in Japanese revisited
Authors: Hatakeyama Yuji , Honda Kensuke , Tanaka Kosuke
Published: June 2017

This paper argues for verb movement in Japanese. In Taro-ga sushi-o mo tabe-ta 'Taro also ate sushi,' for example, we claim that tabe 'eat' actually moves past mo 'also,' as in [Taro-ga sushi-o t tabe mo tabe-ta]. This analysis is supported by the interpretation of the adjunct clitic mo. We further claim that the verb-movement operation, coupled with the so-called Morphological Merger, successfully accounts for various data involving su-support (analogous to do-support in English). As a consequence, the present analysis has an important implication for the language typology on verb movement.
On the nature of the complementizer to
Authors: Saito Mamoru
Published: June 2017

This paper proposes that the Japanese complementizer to is not a comp for propositions as is widely assumed, but is a comp for reports of direct discourse. Plann (1982) argues that que in Spanish is ambiguous between a comp for propositions and a comp for reports. I first motivate the proposal by demonstrating the parallelism between to and que. Then, I show that to, unlike que, is employed specifically for reports of direct discourse. I argue that there is a division of labor between to and another complementizer no: the former is for reports and the latter is for propositions. Finally, I discuss the distribution of to in wider contexts, for example in adjunct CPs, and present further evidence for the proposal.
The verb doubling construction in Japanese
Authors: Hatakeyama Yuji , Honda Kensuke , Tanaka Kosuke
Published: June 2017

Japanese has expressions such as Basu-ga ki-ta ki-ta ‘A bus has finally come,’ where the verb-tense complex (ki-ta ‘came’ in this example) is doubled. This paper concentrates on these kinds of expressions, calling them the verb doubling construction (henceforth the VDC). The aim of this paper is to investigate the syntactic structure of the VDC in Japanese. Providing five pieces of evidence that the repeated verb-tense complex occupies the head of CP, we claim that the VDC constitutes a CP structure. We further point out that the analysis proposed here strongly supports the copy theory of movement (Chomsky, 1993).
Submergence of lexically encoded egocentricity in syntax: The case of subjective emotion predicates in Japanese
Authors: Minagawa Harumi
Published: June 2017

In Japanese, subjective emotion predicates such as kanashii ‘sad’ and tsurai ‘painful’ are exclusively used to describe the inner state of the speaker, reflecting a highly subjective construal. This study investigates systematically how emotion is expressed in formal but confidential narrative texts, in which the egocentric perspective normally conveyed by these predicates would be inappropriate. In the data examined, subjective predicates occurred very infrequently in the form of direct assertions. Instead, a range of syntactic structures is used which reflect a departure from a subjective construal; the emotion is either presented as severed in some way from the experiencer or a separate reporting self emerges, distanced from the experiencing self. These syntactic structures reflect a less egocentric, more objective construal of emotion, suitable for this narrative genre. In this way, syntax is shown to work to obscure the linguistic privilege lexically encoded in subjective emotion predicates in Japanese.
/p/-driven geminate devoicing in Japanese: Corpus and experimental evidence
Authors: Kawahara Shigeto , Sano Shin-ichiro
Published: June 2017

In Japanese loanwords, voiced geminates can be devoiced in the presence of another voiced obstruent (e.g., /doggu/ → /dokku/ ‘dog’). This devoicing pattern has been studied extensively in the recent phonological literature in terms of theoretical modeling as well as from the perspective of experimentation and corpus studies. Less well-known is the observation that /p/ may cause devoicing of geminates as well (e.g., /piramiddo/ → /piramitto/ ‘pyramid’), although to date no objective evidence has been offered to confirm this observation. The current study thus attempts to test this observation objectively by way of a corpus study and two phonological judgment experiments. The results generally support the idea that /p/ can cause devoicing of geminates in Japanese loanwords; in other words, /p/ may trigger Lyman’s Law in causing devoicing of geminates. In addition to this descriptive discovery, throughout the paper we discuss intriguing task effects in phonological experimentation, by comparing the corpus data and the results of the two judgment experiments. Although our aim is primarily descriptive, we offer some analytical possibilities for the /p/-driven devoicing of geminates at the end of the paper.
Linear Irreversible Phenomenological Thermodynamics of Polarization Processes in Rigid Unmagnetic Insulators
Authors: Wieth Patrick , Ellermeier Wolfgang
Published: June 2017

We show how classical irreversible thermodynamics is used to derive relaxation equations for dielectric polarization processes in insulators. We calculate susceptibilities for multiple polarization processes and show how coupling arises thermodynamically. Furthermore, we derive evolution equations for electromagnetic fields by combining the dielectric relaxation equations with Maxwell’s equations. Analytical solutions for various frequency regimes will be briefly discussed. A complete analogy exists between the dielectric problem, the Kelvin–Voigt viscoelasticity of solid media, and the non-equilibrium (reactive, vibrational) gasdynamic flow. Also, numerical solutions, using the method of characteristics, are given for a generic signal problem in half-space.
Excessive weight gain in exclusively breast-fed infants
Authors: Saure Carola , Armeno Marisa , Barcala Consuelo , Giudici Vanesa , Mazza Carmen Silvia
Published: June 2017

Background:

Breastfeeding is recommended as the best source of nutrition in the first months of life and observational studies have associated exclusive breastfeeding with decreased weight gain and a protective effect against obesity in childhood. The objective of this study was to describe the characteristics of a cohort of exclusively breastfed obese infants to determine factors that may lead to this unusual weight gain.

Methods:

Infants seen between 2003 and 2015 who were exclusively breastfed and showed excessive weight gain in the first year of life were followed with a focus on features of the mother, the child, feeding patterns and the presence of concomitant factors that influence nutritional status. Additionally, in a subset of the sample, macronutrients of the maternal breast milk were analyzed. A descriptive, prospective cross-sectional study was conducted.

Results:

Of 73 patients, 63% were girls. At 3 months of life, 64% had a weight-for-height standard deviation score (SDS) >2. At 6 and at 12 months, 100% of the patients had a weight-for-height >2 SDS. The mean age at semisolid-food introduction was 7 months. The mean age at weaning was 15.8 months. The babies were fed on demand and no hunger-satiety pattern was observed. In the breast milk samples analyzed, a significantly lower fat content was found.

Conclusions:

The results of our study lead to the assumption that inter-individual variations in mother’s milk composition may affect the growth patterns of children.
Pulmo uterinus: a history of ideas on fetal respiration
Authors: Obladen Michael
Published: June 2017

Theories about fetal respiration began in antiquity. Aristotle characterized pneuma as warm air, but also as the enabler of vital functions and instrument of the soul. In Galen’s system of physiology, the vital spirit was carried by the umbilical arteries, the nutrients by the umbilical vein from the placenta to the fetus. In 1569 Aranzio postulated that the maternal and fetal vasculatures are distinct. From 1670 to 1690, a century before the discovery of oxygen, researchers understood that during respiration some form of exchange with the air must occur, naming the substance biolychnium, phlogiston, sal-nitro, or nitro-aerial particles. An analogy of placental and pulmonary gas exchange was described in 1674 by Mayow. In 1779, Lavoisier understood the discovery of oxygen, discarded the phlogiston theory, and based respiration physiology on gas exchange. With the invention of the spectroscope, it became possible to measure hemoglobin oxygenation, and in 1876 Zweifel proved fetal oxygen uptake. Major progress in understanding fetal gas exchange was achieved in the 20th century by the physiologists Barcroft in Cambridge and Dawes in Oxford.
The development of finiteness in the Transeurasian languages
Authors: Robbeets Martine
Published: June 2017

Nonfinite verb forms can gradually acquire morphological and syntactic properties of finiteness. Across the languages of the world, such developments can follow various pathways with various results. In this article, I first discuss the four major pathways mechanisms for developing finite function on formerly nonfinite forms. Next, I argue that the Transeurasian languages (i. e., Japanese, Korean, Tungusic, Mongolic, and Turkic languages) share a common mechanism. Historical reconstruction indicates that these languages all show the tendency to reanalyze directly a nonfinite verb form as a finite one, without the omission of a specific matrix verb. I refer to this tendency as “indirect insubordination”. I argue that the recurrence of indirect insubordination on formally related suffixes can be taken as an indication of common ancestorship.
The crust structure of the Morasko meteorite – a preliminary hypothesis
Authors: Stankowski Wojciech T.J.
Published: June 2017

A small piece of the Morasko meteorite, weighing 970 g, yields traces of its journey through the Earth’s atmosphere and of its impact into a mineral substrate, such as reflected in the meteorite’s crust. This is seen in the crust structure in the form of sintered as well as fusion and semi-fusion layers for which ablative niches are optimum sites. Subsequent weathering processes have resulted in significant mineralogical changes in the crusts. The meteorite crusts originated during polygenetic processes.
Features of Synchronous Electronically Commutated Motors in Servomotor Operation Modes
Authors: Dirba J. , Lavrinovicha L. , Dobriyan R.
Published: June 2017

The authors consider the features and operation specifics of the synchronous permanent magnet motors and the synchronous reluctance motors with electronic commutation in servomotor operation modes. Calculation results show that mechanical and control characteristics of studied motors are close to a linear shape. The studied motor control is proposed to implement similar to phase control of induction servomotor; it means that angle θ (angle between vectors of the supply voltage and non-load electromotive force) or angle ε (angle between rotor direct axis and armature magnetomotive force axis) is changed. The analysis results show that synchronous electronically commutated motors could be used as servomotors.
Freedom of Conscience and Freedom of Religion within the Context of Human Security and Authenticity in Vito Mancuso’s Lay Secular Theology
Authors: Simuţ Corneliu C.
Published: June 2017

Vito Mancuso, one of Italy’s most famous intellectuals and author of best-selling books on religion – such as
Factors influencing the accumulation of Pb in sediments of deep and shallow dam reservoirs
Authors: Czaplicka Anna , Szarek-Gwiazda Ewa , Ślusarczyk Zbigniew
Published: June 2017

The study determines the differences in Pb accumulation in sediments of dam reservoirs with respect to locations of the old river beds and their depth (deep Czorsztyn Reservoir and shallow Goczałkowice Reservoir in southern Poland). Parameters (grain size, organic matter content and reservoir depth) that may influence the spatial distribution of Pb concentrations in the sediments were analyzed. Based on the hierarchical cluster analysis, sediment samples from the reservoirs were ranked with respect to particle size distribution. We found differences in the spatial distribution of grain size and organic matter in the studied reservoirs, caused mostly by the topography of these reservoirs. The spatial distribution of Pb concentrations in the sediments of the Czorsztyn Reservoir (range 4.8-35.8 μg g-1) and the Goczałkowice Reservoir (range 11.3-59.4 μg g-1), regardless of their average depth and their type (dimictic, polymictic), depends on the distribution of silty clay and clay fractions, organic matter and reservoir depth. Therefore, Pb spatial distribution was more regular in the Czorsztyn Reservoir than in the Goczałkowice Reservoir. Locations of the old river beds had a significant impact on the Pb distribution in the sediments of both reservoirs.
Analysis of zooplankton assemblages from man-made ditches in relation to current velocity
Authors: Czerniawski Robert , Sługocki Łukasz
Published: June 2017

Because of the slow current velocity, man-made ditches may create distinct physical and ecological conditions that are suitable for the growth of zooplankton populations. However, the influence of drainage ditches on zooplankton communities has not been studied yet. This study aims to answer the following questions: i) Are man-made ditches a rich source of zooplankton? ii) What current velocity value leads to abundant zooplankton in man-made ditches? iii) Do zooplankton communities differ between man-made ditches and connected natural streams? In man-made drainage ditches with a water current lower than 0.1 m s-1, the abundance of zooplankton was greater than in the majority of streams. Sometimes this level of abundance was equivalent to the densities of zooplankton in lakes or dammed reservoirs. The presence of zooplankton in man-made ditches may be of great importance to the establishment of food webs, particularly during periods of high water levels or heavy rainfall, both of which may accelerate the water current, causing the dispersion of zooplankton along the ditches and into natural streams.
Comparative Study of Machining Technology Selection to Manufacture Large-Size Components of Offshore Constructions
Authors: Deja Mariusz , Siemiątkowski Mieczysław , Sender P.
Published: June 2017

The focus of this paper is on process planning for large parts manufacture in systems of definite process capabilities, involving the use of multi-axis machining centres. The analysis of machining heavy mechanical components used in off-shore constructions has been carried out. Setup concepts applied and operation sequences determined in related process plans underwent studies. The paper presents in particular a reasoning approach to setup sequencing and machine assignment in manufacturing large-size components of offshore constructions. The relevant reasoning mechanism within a decision making scheme on generated process plan is shown based on a case study derived from the offshore sector. Recommendations for manufacture of selected exemplary and typical parts were formulated.
Modelling and Simulation of a New Variable Stiffness Holder for Milling of Flexible Details
Authors: Kaliński Krzysztof J. , Galewski Marek A. , Mazur Michał , Chodnicki Marek
Published: June 2017

Modern industry expectations in terms of milling operations often demand the milling of the flexible details by using slender ball-end tools. This is a difficult task because of possible vibration occurrence. Due to existence of certain conditions (small depths of cutting, regeneration phenomena), cutting process may become unstable and self-excited chatter vibration may appear. Frequency of the chatter vibration is close to dominant natural frequency of the workpiece or the tool. One of the methods of chatter vibration avoidance is matching the spindle speed to the optimum phase shift between subsequent cutting edges passes (i.e. the Liao-Young condition). However, the set of optimum spindle speeds from the point of view of vibration reduction may be not optimum one from other points of view. For example milling efficiency or machine tool capabilities cannot be assured. This article presents the idea of a workpiece holder with adjustable stiffness and discusses a new variant of its realization. In the holder, milling process is performed at constant spindle speed and feed speed. In order to avoid vibration the holder stiffness is modified. Stiffness changes modify natural frequencies of the workpiece and thus it is possible to modify dynamic properties of the workpiece in such a way that arbitrary chosen, constant spindle speed will be optimum, due to the Liao-Young condition performance. Calculation of the optimum stiffness is performed before milling, based on the workpieces modal identification results and the finite element model simulations.
Investigations On Water Circulation in Animal Sea-Water Basins – On the Example of Seals′ Breeding Pools
Authors: Zima Piotr
Published: June 2017

This paper presents general comments concerning investigations on water circulation in animal breeding pools containing sea water. As an example are given results of computer simulation of water circulation in seals′ breeding pools situated in Marine Station at Hel, belonging to Oceanographic Institute , Gdansk University. A mathematical model of three main pools was prepared with taking into account their inflow and outflow water supply points. Next, the object indication ( tracer) tests were done with the use of mathematical modelling as well as in-situ measurements. For description of flow field in steady conditions a simplified model of 2D flow in the form of Helmholtz biharmonic equation of stream function , recalculated then into velocity vector components, was used. The equation , supplemented with appropriate boundary conditions , was solved numerically by using the finite differences method. The spreading of a substance dissolved in water (tracer) was analyzed by solving 2D equation of transient advecting - dispersing transport. To solve it the finite volumes method was applied. The applied model was verified by conducting the indication tests with the use of the rhodamine WT as a tracer. The obtained results made it possible to reconstruct water circulation within the seals′ pools and identify stagnation zones in which water circulation may be made difficult.
Design of Structure of Tension Leg Platform for 6 MW Offshore Wind Turbine Based On Fem Analysis
Authors: Żywicki Jędrzej , Dymarski Paweł , Ciba Ewelina , Dymarski Czesław
Published: June 2017

The article presents the calculation and design stages of the TLP platform serving as a supporting construction of a 6 MW offshore wind turbine. This platform is designed to anchor at sea at a depth of 60 m. The authors presented the method of parameterization and optimization of the hull geometry. For the two selected geometry variants, the load and motion calculations of the platform subjected to wind, wave and current under 50-year storm conditions were performed. The maximum load on the structure was determined in these extreme storm conditions. For these loads, the MES calculation of the designed platform was performed for the selected variant. Authors have presented a method for calculating maximum wind, wave and current stresses on the structure during the worst storm in the past 50 years. For these loads the MES endurance calculations of the designed platform were made. Based on the results of these calculations, the required structural changes and recalculations have been made in succession to the structural design of the platform, which meets the design requirements and has the required ad hoc strength. The article contains stress analysis in „difficult“ nodes of constructions and discusses ways of solving their problems. The work is part of the WIND-TU-PLA project from the NCBR Research Agreement (Agreement No. MARTECII / 1/2014).
Experimental pharmacokinetics evaluation of chemotherapy delivery by PIPAC for colon cancer: first evidence for efficacy
Authors: Eveno Clarisse , Haidara Aminata , Ali Ibrahim , Pimpie Cynthia , Mirshahi Massoud , Pocard Marc
Published: June 2017

Background

Pressurised intraperitoneal aerosol chemotherapy (PIPAC) is a novel technique of intraperitoneal chemotherapy devoted to unresectable peritoneal metastasis (PM). The first results obtained with PIPAC in preclinical models of colon cancer are presented here.

Methods

In vitro, PIPAC (normotherm oxaliplatin at 0.028 mg/mL for 10 min at 1.6 bars) and HIPEC (hyperthermic oxaliplatin at 0.14 mg/mL for 30 min) were compared using the apoptosis and proliferation assay on two colon cancer cell lines (LS 174 and CT 26); ex vivo tumours from an orthotopic mouse model of PM and non-tumour peritoneum from a patient treated according to the two modalities were assessed, investigating the percentage of penetration of oxaliplatin in the tumour and oxaliplatin concentration below the peritoneum. In vivo, a mouse model of colon (CT 26) PM was used to create a PIPAC model (same modalities) for the comparison of IV oxaliplatin (at 5 mg/mL).

Results

In vitro, the rate of apoptotic and proliferative cells as well as the level of oxaliplatin penetration in tumour nodes was higher in PIPAC groups with less systemic passage through the peritoneum. In vivo, in the colon PM mouse model, the peritoneal cancer index (PCI) was decreased to the same level using PIPAC or IV oxaliplatin. Systemic passage was lower in the PIPAC group.

Conclusions

PIPAC with low-dose oxaliplatin is efficient in both in vitro and in vivo models of colon PM. Lower concentrations of chemotherapy are needed in PIPAC to achieve the same effect as IV chemotherapy on PCI. With a very low systemic oxaliplatin passage, this technique of drug delivery seems to be as effective as IV delivery for PM control.
Principles of ‘Newspeak’ in Polish Translations of British and American Press Articles under Communist Rule
Authors: Źrałka Edyta
Published: June 2017

The paper analyses selected Polish translations of British and American press articles published in the magazine Forum in the years 1965 – 1989. In communist Poland, all such texts were censored before publication, which forced the translators to avoid content and language that could be banned by censors and to adopt a specific style of expression known as Newspeak. The paper lists the linguistic phenomena in the target language that represent features typical of Newspeak and identifies manipulative procedures which led to their occurrence, using a corpus of 25 English texts and their Polish translations.
Interlocutors-Related and Hearer-Specific Causes of Misunderstanding: Processing Strategy, Confirmation Bias and Weak Vigilance
Authors: Padilla Cruz Manuel
Published: June 2017

Noises, similarities between words, slips of the tongue, ambiguities, wrong or false beliefs, lexical deficits, inappropriate inferences, cognitive overload, non-shared knowledge, topic organisation or focusing problems, among others, may cause misunderstanding. While some of these are structural factors, others pertain to the speaker or to both the speaker and the hearer. In addition to stable factors connected with the interlocutors’ communicative abilities, cultural knowledge or patterns of thinking, other less stable factors, such as their personal relationships, psychological states or actions motivated by physiological functions, may also result in communicative problems. This paper considers a series of further factors that may eventually lead to misunderstanding, and which solely pertain to the hearer: processing strategy, confirmation bias and weak vigilance.
What Was a Relevant Translation in the 18th Century?
Authors: Vasileanu Monica
Published: June 2017

The paper applies RT to analyse an 18th century translation of a Latin text by the preeminent Romanian scholar Demetrius Cantemir. The translation diverges significantly from the original and was met with harsh criticism. Using the conceptual toolkit of RT, I argue that the differences between the original and its English translation were motivated by the translator’s desire to yield the same cognitive effect without putting the audience to unnecessary processing effort. Both effects and effort need to be evaluated by taking into account the respective cognitive environments of the source-text and the target-text audiences. The intertextual dimension of the text under scrutiny adds to the difficulty of communicating the same message in different languages and cultures.
Cultural differences and their impact on the ecumenical issue in today’s Judaism
Authors: Pătru Alina
Published: June 2017

It is not only the case of Christianity that different religious options spring from cultural differences, but it goes the same for other religions too, even for ethnic religions. Using the example of today Judaism, this study seeks to show how different cultural backgrounds lead to different religious forms, and how they may bring about tensions between members of the same religion. I shall bring up to discussion situations where the cultural differences are finally bridged, as well as others where they persist, feeding the strained relationship. Via the example of Judaism, I shall elaborate on the importance of non-religious factors in the appearance of confessional differences and the attitude towards other practitioners. The material allows theologians to draw a comparison with the situation within Christianity and to reach to useful conclusions for Christian ecumenism.
Rapid liquid chromatography tandem mass spectrometry determination of rivaroxaban levels in human plasma for therapeutic drug monitoring
Authors: Varga Andreea , Șerban Răzvan Constantin , Muntean Daniela Lucia , Tătar Cristina Maria , Farczadi Lenard , Tilea Ioan
Published: June 2017

A rapid, sensitive, high-throughput liquid chromatography coupled with tandem mass spectrometry method for the quantification of rivaroxaban from human plasma has been developed and validated. For the analytical separation a Zorbax SB-C18 column with isocratic flow of mobile phase composed of 0.2% formic acid in water and acetonitril (65:35, V/V) with a flow rate of 1 mL/min at a temperature of 45ºC was used. Detection of rivaroxaban was performed using positive electrospray ionization and MS/MS mode (sum of m/z 231.1; 289.2 and 318.2 from m/z 436.3). Plasma samples were prepared using single-step protein precipitation with methanol. Method validation was performed with regards to selectivity, linearity (r >0.9927), within-run and between-run precision (CV< 13.1 %) and accuracy (bias< 9.4 %) over a concentration range of 24.00 - 960.00 ng/mL plasma. Recovery was between 96.5 - 108.5% and the lower limit of quantification of rivaroxaban was 24.00 ng/mL. The developed method is simple, rapid, and selective, requires small plasma sample volumes, and was successfully applied for therapeutic drug monitoring of rivaroxaban in treated patients.
Robin Hood: A cost-efficient two-stage approach to large-scale simultaneous inference with non-homogeneous sparse effects
Authors: Pecanka Jakub , Goeman Jelle
Published: June 2017

A classical approach to experimental design in many scientific fields is to first gather all of the data and then analyze it in a single analysis. It has been recognized that in many areas such practice leaves substantial room for improvement in terms of the researcher’s ability to identify relevant effects, in terms of cost efficiency, or both. Considerable attention has been paid in recent years to multi-stage designs, in which the user alternates between data collection and analysis and thereby sequentially reduces the size of the problem. However, the focus has generally been towards designs that require a hypothesis be tested in every single stage before it can be declared as rejected by the procedure. Such procedures are well-suited for homogeneous effects, i.e. effects of (almost) equal sizes, however, with effects of varying size a procedure that permits rejection at interim stages is much more suitable. Here we present precisely such multi-stage testing procedure called Robin Hood. We show that with heterogeneous effects our method substantially improves on the existing multi-stage procedures with an essentially zero efficiency trade-off in the homogeneous effect realm, which makes it especially useful in areas such as genetics, where heterogeneous effects are common. Our method improves on existing approaches in a number of ways including a novel way of performing two-sided testing in a multi-stage procedure with increased power for detecting small effects.
Stress-Dilatancy for Soils. Part III: Experimental Validation for the Biaxial Condition
Authors: Szypcio Zenon
Published: June 2017

The validation of the general stress-dilatancy relationship is shown based on biaxial compression test data presented in the literature under drained and undrained conditions. Rowe’s and Bolton’s relationships can be treated as simplified forms of the general stress-dilatancy relationship. The stress ratio values are a function of not only the dilatancy but also the intermediate principal stress, the non-coaxiality angle defined by Gutierrez and Ishihara and the stress-strain path. For many granular soils, the critical frictional state angle of the shearing resistance Φo = Φ′cv and parameters α and β are functions of the drainage condition, the stress level and the stress and strain paths.
Survival of node-negative breast cancer patients treated at the university medical centre Maribor in the period 2000–2009
Authors: Fokter Dovnik Nina , Arko Darja , Čas Sikošek Nina , Takač Iztok
Published: June 2017

Introduction

Breast cancer is increasingly diagnosed in the early stages without regional nodal involvement. The aim of the present study was to determine the 5-year overall (OS) and breast cancer specific survival (BCSS) for patients with node-negative breast cancer treated at the University Medical Centre Maribor, and compare it with survival at the national level.

Methods

Medical records were searched for information on patients with lymph node-negative invasive breast cancer who received primary treatment at the University Medical Centre Maribor in the period 2000–2009. Information on all Slovenian node-negative breast cancer patients diagnosed in the same period was obtained from the Cancer Registry of Republic of Slovenia. Time trends in survival were assessed by comparing the periods 2000–2004 and 2005–2009.

Results

The 5-year OS and BCSS of patients treated in Maribor in the period 2000–2009 were 92.3% (95% CI, 90.5%– 94.1%) and 96.4% (95% CI, 95.2%–97.6%), respectively, and did not differ from the corresponding OS and BCSS for Slovenian patients. Although the improvement in OS for patients from Maribor diagnosed in the period 2005–2009 compared to 2000–2004 did not reach statistical significance (HR 0.73; 95% CI, 0.51–1.05; p=0.086), BCSS significantly improved over the same time periods (HR 0.53; 95% CI, 0.30–0.94; p=0.028).

Conclusions

Survival of node-negative breast cancer patients treated at the University Medical Centre Maribor is comparable to survival of corresponding patients at the national level. The rising number of long-term breast cancer survivors places additional importance on survivorship care.
White matter sexual dimorphism of the adult human brain
Authors: Bourisly Ali K. , Gejo Grace , Hayat Abrar A. , Alsarraf Lamya , Dashti Fatima M. , Di Paola Margherita
Published: June 2017

Sex-biased psychophysiology, behavior, brain function, and conditions are extensive, yet underlying structural brain mechanisms remain unclear. There is contradicting evidence regarding sexual dimorphism when it comes to brain structure, and there is still no consensus on whether or not there exists such a dimorphism for brain white matter. Therefore, we conducted a voxel-based morphometry (VBM) analysis along with global volume analysis for white matter across sex. We analyzed 384 T1-weighted MRI brain images (192 male, 192 female) to investigate any differences in white matter (WM) between males and females. In the VBM analysis, we found males to have larger WM, compared to females, in occipital, temporal, insular, parietal, and frontal brain regions. In contrast, females showed only one WM region to be significantly larger than males: the right postcentral gyrus in the parietal lobe region. Although, on average, males showed larger global WM volume, we did not find any significant difference in global WM volume between males and females.
New Studies of Marcion’s Evangelion
Authors: BeDuhn Jason
Published: June 2017

Several recent publications have brought renewed vigor to the study of Marcion’s gospel text, the
Marcion’s Gospel and the Resurrected Jesus of Canonical Luke 24
Authors: Smith Daniel A.
Published: June 2017

New reconstructions of Marcion’s
Building verbs in language mixing varieties
Authors: Alexiadou Artemis
Published: June 2017

This paper discusses two patterns of language mixing involving verbal predicates produced by bilingual speakers,
the so-called light verb construction and the so-called affixal pattern. The empirical focus of the study is on Greek-German
and Cypriot Greek-English varieties, which are contrasted to the Spanish-German variety discussed in González-Vilbazo
and López (2011). An analysis of the constructions is offered using the tools of Distributed Morphology and Minimalist
Syntax. The paper shows that bilingual speakers have very detailed knowledge of fine properties of their two linguistic
systems that become apparent in the context of building verbs.
Supramolecular architectures in N-(4-bromobenzoyl)-arylsulfonamides: crystal structures and Hirshfeld surface analysis
Authors: Naveen Shivalingegowda , Sudha Achar Gurumurthy , Suresha Erachikkaiah , Lokanath Neratur Krishnappagowda , Suchetan Parameshwar Adimule
Published: June 2017

A detailed analysis of the molecular packing of five N-(4-bromobenzoyl)-substituted benzenesulfonamides, i-X~4-Br (1–5) [i-X=H, 2-CH3, 4-CH3, 2-Cl, 4-Cl] is presented. The intermolecular interactions and the packing patterns are evaluated along with an analysis of their Hirshfeld surfaces and fingerprint plots (FP). The crystals feature molecular self-assembly through N–H···O hydrogen-bonds forming three types of supramolecular synthon:

 C

1
1

(
4
)

${\rm{C}}_1^1(4)$

chain,

R
4
4

(
16
)

${\rm{R}}_4^4(16)$

tetramer and

R
2
2

(
8
)

${\rm{R}}_2^2(8)$

ring. These molecular assemblies extend to form one-dimensional (1D), 2D or 3D supramolecular architectures via diverse intermolecular interactions. A study of 33 i-X~4-Y (Y=H, CH3, OCH3, NO2, F, Cl, Br) structures shows the substituent on the sulfonamide ring modulates the intermolecular interactions and the subsequent supramolecular architectures drastically, with the fluoro- and bromo-substituted analogues providing distinctive self-assemblies. The

R
4
4

(
16
)

${\rm{R}}_4^4(16)$

synthon produced by N–H···O hydrogen-bonds in the 4-CH3~4-Br derivative is a rare phenomenon amongst a set of 74 i-X~j-Y structures.
Performance Test of Openflow Agent on Openflow Software-Based Mikrotik RB750 Switch
Authors: Kartadie Rikie
Published: June 2017

A network is usually developed by several devices such as router, switch etc. Every device forwards data package manipulation with complicated protocol planted in its hardware. An operator is responsible for running configuration either to manage rules or application applied in the network. Human error may occur when device configuration run manually by operator. Some famous vendors, one of them is MikroTik, has also been implementing this OpenFlow on its operation. It provides the implementation of SDN/OpenFlow architecture with affordable cost. The second phase research result showed that switch OF software-based MikroTik resulted higher latency value than both mininet and switch OF software-based OpenWRT. The average gap value of switch OF software-based MikroTik is 2012 kbps lower than the value of switch OF software-based OpenWRT. The average gap value of throughput bandwidth protocol UDP switch OF software-based MikroTik is 3.6176 kBps lower than switch OF software-based OpenWRT and it is 8.68 kBps lower than mininet. The average gap throughput jitter protokol UDP of switch OF software-based MiktoTik is 0.0103ms lower than switch OF software-based OpenWRT and 0.0093ms lower than mininet.
Role of miR-383 and miR-146b in different propensities to obesity in male mice
Authors: Xia Shu-Fang , Duan Xiao-Mei , Cheng Xiang-Rong , Chen Li-Mei , Kang Yan-Jun , Wang Peng , Tang Xue , Shi Yong-Hui , Le Guo-Wei
Published: June 2017

The study was designed to investigate the possible mechanisms of hepatic microRNAs (miRs) in regulating local thyroid hormone (TH) action and ultimately different propensities to high-fat diet (HFD)-induced obesity. When obesity-prone (OP) and obesity-resistant (OR) mice were fed HFD for 7 weeks, OP mice showed apparent hepatic steatosis, with significantly higher body weight and lower hepatic TH receptor b (TRb) expression and type 1 deiodinase (DIO1) activity than OR mice. Next-generation sequencing technology revealed that 13 miRs in liver were dysregulated between the two phenotypes, of which 8 miRs were predicted to target onDio1orTRb. When mice were fed for 17 weeks, OR mice had mild hepatic steatosis and increasedDio1andTRbexpression than OP mice, with downregulation of T3 target genes (includingSrebp1c,Acc1,Scd1andFasn) and upregulation ofCpt1α,Atp5c1,Cox7candCyp7a1. A stem-loop qRT-PCR analysis confirmed that the levels of miR-383, miR-34a and miR-146b were inversely correlated with those of DIO1 or TRb. Down-regulated expression of miR-383 or miR-146b by miR-383 inhibitor (anti-miR-383) or miR-146b inhibitor (anti-miR-146b) in free fatty acid-treated primary mouse hepatocytes led to increased DIO1 and TRb expressions, respectively, and subsequently decreased cellular lipid accumulation, while miR-34a inhibitor (anti-miR-34a) transfection had on effects on TRb expression. Luciferase reporter assay illustrated that miR-146b could directly targetTRb3′untranslated region (3′UTR). These findings suggested that miR-383 and miR-146b might play critical roles in different propensities to diet-induced obesity via targeting onDio1andTRb, respectively.
RNA Binding Protein Vigilin Collaborates with miRNAs To Regulate Gene Expression for Caenorhabditis elegans Larval Development
Authors: Zabinsky Rebecca A , Weum Brett M , Cui Mingxue , Han Min
Published: June 2017

Extensive studies have suggested that most miRNA functions are executed through complex miRNA-target interaction networks, and such networks function semiredundantly with other regulatory systems to shape gene expression dynamics for proper physiological functions. We found that knocking down vgln-1, which encodes a conserved RNA-binding protein associated with diverse functions, causes severe larval arrest at the early L1 stage in animals with compromised miRISC functions (an ain-2/GW182 mutant). Through an enhancer screen, we identified five specific miRNAs, and miRNA families, that act semiredundantly with VGLN-1 to regulate larval development. By RIP-Seq analysis, we identified mRNAs that are directly bound by VGLN-1, and highly enriched for miRNA binding sites, leading to a hypothesis that VGLN-1 may share common targets with miRNAs to regulate gene expression dynamics for development.