bluuebunny/crossref_metadata_2025 huggingface dataset:
Faktor-Faktor Yang Mempengaruhi Kualitas Hidup Orang Dengan Hiv/Aids (ODHA)
Authors: Kolbi Vindi elok latifatul
Published: November 2022

Latar Belakang: Seluruh Dunia masih dihadapkan oleh permasalahan yang sama yakni HIV/AIDS. Penyakit yang tak kunjung usai ini cukup membahayakan mengingat belum adanya obat untuk penyakit ini hanya ada Anti Retro Viral (ARV) yang merupakan obat untuk membekukan virus dan mempertahankan hidup Data terakhir sampai Maret 2021, seperti dilaporkan oleh Ditjen P2P, Kemenkes RI, tanggal 25 Mei 2021, menunjukkan jumlah kumulatif kasus HIV/AIDS di Indonesia sebanyak 558.618 yang terdiri atas 427.201 HIV dan 131.417 AIDS.
Tujuan: tujuan dalam penelitian ini adalah untuk mengetahui factor-faktor yang mempengaruhi Kualitas Hidup Orang Dengan Hiv/Aids (ODHA).
Metode: Metode yang digunakan dalam analitik ini adalah systematic literatur review, mengenai factor-faktor yang mempengaruhi kualitas hidup Orang Dengan Hiv/Aids(ODHA)  menggunakan modifikasi Population, Intervensi, Outcom (PICO) dengan database elektronik garuda, google schooler dan neliti. Menggunakan kata kunci. Kriteria inklusi dan eksklusi artikel dengan tahun terbit 2013-2021, responden seluruh Orang Dengan Hiv/Aids (ODHA) yang terdampingi, menggunakan metode RATER, artikel full text.
Ulasan: menunjukkan 7 jurnal dengan berbagai variable diukur pengaruhnya dimana 4 jurnal dengan variable sama dan 3 jurnal variable berkaitan dihasilkan 7 variabel tidak berpengaruh dan lainnya memiliki pengaruh signifikan. Berdasarkan 7 jurnal tersebut didapatkan  dengan hasil akhir 9 variabel berhubungan dengan 2 barkaitan memiliki pengaruh tertinggi terhadap kualitas Hidup Orang Dengan Hiv/Aids (ODHA).
Kesimpulan: Kesimpulan yang dapat diambil bahwasannya dukungan social merupakan factor yang paling berpengaruh terhadap Kualitas hidup Odha. Setelah itu disusul oleh factor kepatuhan dalam minum obat juga memiliki pengaruh yang cukup tinggi. Dalam hal ini peran keluarga sangat diperlukan. Factor depresi memiliki pengaruh 10 kali lipat disbanding jrnis kelamin, status marital serta stadium penyakit terhadap kualitas hidup Orang Dengan Hiv/Aids (ODHA). Saran yang dsebaiknya dibutuhkan adalah peran social, peran pemerintah dalam membuat kebijakan, layanan kesehatan dalam memprhatikan pasien HIV/AIDS, serta control pandangan masyarakat terhadap Orang Dengan Hiv/Aids (ODHA). Factor lain yang juga mempengaruhi kualitas hidup Orang Dengan Hiv/Aids (ODHA) adalah pendidikan, pengetahuan, status marital serta jenis kelamin.
Multi-epitope mRNA Vaccine Design that Exploits Variola Virus and Monkeypox Virus Proteins for Elicitation of Long-lasting Humoral and Cellular Protection Against Severe Disease
Authors: Kovačić Dženan , Salihović Adna
Published: November 2022

Human monkeypox represents a relatively underexplored infection that has received increased attention since the reported outbreak in May 2022. Due to its clinical similarities with human smallpox, this virus represents a potentially tremendous health problem demanding further research in the context of host-pathogen interactions and vaccine development. Furthermore, the cross-continental spread of monkeypox has reaffirmed the need for devoting attention to human poxviruses in general, as they represent potential bioterrorism agents. Currently, smallpox vaccines are utilized in immunization efforts against monkeypox, an unsurprising fact considering their genomic and phenotypic similarities. Though it offers long-lasting protection against smallpox, its protective effects against human monkeypox continue to be explored, with encouraging results. Taking this into account, this works aims at utilizing in silico tools to identify potent peptide-based epitopes stemming from the variola virus and monkeypox virus proteomes, to devise a vaccine that would offer significant protection against smallpox and monkeypox. In theory, a vaccine that offers cross-protection against variola and monkeypox would also protect against related viruses, at least in severe clinical manifestation. Herein, we introduce a novel multi-epitope mRNA vaccine design that exploits these two viral proteomes to elicit long-lasting humoral and cellular immunity. Special consideration was taken in ensuring that the vaccine candidate elicits a Th1 immune response, correlated with protection against clinically severe disease for both viruses. Immune system simulations and physicochemical and safety analyses characterize our vaccine candidate as antigenically potent, safe, and overall stable. The protein product displays high binding affinity towards relevant immune receptors. Furthermore, the vaccine candidate is to elicit a protective, humoral and Th1-dominated cellular immune response that lasts over five years. Lastly, we build a case about the rapidity and convenience of circumventing the live attenuated vaccine platform using mRNA vaccine technology.
Strategi Mitigasi Risiko Terhadap Aset Keuangan dan Fisik Koperasi Melalui Penerapan Key Risk Indicators
Authors: Nugraha Muhamad , Aini Nurul
Published: November 2022

Aset merupakan bagian dari kekayaan yang dimiliki oleh suatu industri dan perlu dilakukan pengendalian sehingga risiko kerugian dapat diidentifikasi dan dihindari, termasuk yang terjadi pada entitas/sektor “koperasi”. Koperasi dalam meningkatkan kinerja tidak hanya bergantung pada aset dari anggota, tetapi juga memerlukan berbagai upaya termasuk operasi bisnis di luar, sehingga dapat memberikan dampak finansial dan operasional. Melalui pendekatan key risk indicator dan analisa kinerja koperasi dengan pengukuran rasio pertumbuhan dan kemandirian, diketahui bahwa terdapat 10 risiko utama dan 15 indikator kunci yang perlu dilakukan mitigasi sebagai langkah pencegahan oleh manajemen Koperasi Pegawai Industri XYZ. Selain itu, strategi mitigasi yang perlu dilakukan pada aspek sasaran Key Risk Indicators Manajemen dan Organisasi, Orang dan Budaya, dan Operasi & Sistem. Sedangkan sisanya pada aspek produk dan layanan dan teknologi yang menjadi pendukung atas mitigasi yang perlu dilakukan. Dengan demikian diharapkan Manajemen Koperasi Industri XYZ dapat melakukan pengendalian risiko atas aset keuangan dan aset fisik yang dimiliki serta meningkatkan pertumbuhan dan kemandirian koperasi secara keberlanjutan.
OPTIMALISASI PENINGKATAN KUALITAS MUTU PENDIDIKAN PROVINSI PAPUA SEBAGAI DAERAH 3T DI INDONESIA
Authors:   Program Studi Hubungan Internasional, Fakultas Psikologi dan Ilmu Sosial Budaya Universitas Islam Indonesia Yogyakarta, Faruqi Tutukansa Aldho , Dwi Tuffahati Enjang ,   Program Studi Hubungan Internasional, Fakultas Psikologi dan Ilmu Sosial Budaya Universitas Islam Indonesia Yogyakarta
Published: November 2022

Indonesia menjadi negara dengan kualitas mutu pendidikan yang tergolong rendah terutama pada daerah 3T (Terluar, Terdepan, Tertinggal). Programme for International Student Assessment 2019 menyatakan bahwa, kualitas pendidikan Indonesia menempati peringkat ke-72 dari 77 negara. Provinsi Papua menjadi wilayah dengan jumlah daerah 3T terbanyak di Indonesia dengan total tiga puluh kabupaten. Rendahnya kualitas mutu pendidikan daerah 3T disebabkan oleh kondisi sosial masyarakat, kualitas sumber daya manusia, hingga akses pendidikan yang tidak merata. Tujuan penulisan ini untuk memberikan gambaran fenomena daerah 3T di Indonesia, seperti kualitas mutu pendidikan di Provinsi Papua. Kemudian, terdapat rekomendasi kebijakan dalam mengoptimalisasikan kualitas mutu pendidikan melalui upaya-upaya pemerintah pusat dan daerah. Penulisan karya tulis ilmiah ini menggunakan jenis metode kualitatif dengan sumber data primer dan sekunder. Apabila dapat dilakukan pemerataan pendidikan di Indonesia beserta peningkatan kualitas mutu tenaga pendidik dan fasilitas pendidikan, maka Indonesia dapat mengejar ketertinggalan dan menjadi negara unggul dalam aspek pendidikan. Kata Kunci: Kualitas Mutu Pendidikan, Daerah 3T, Provinsi Papua, Sumber Daya Manusia
The Light Inside: A Reflection on an Art Program, Traumatised Women and Thriving during the 2020 Pandemic
Authors: Riggs Anne
Published: November 2022

COVID-19 and the lockdown are not the worst things to have been imposed upon the people with whom I work. In fact, their lives marinated in childhood sexual trauma, abuse, neglect, family violence, severe mental ill health, and/or disability, have prepared them well for isolation, self-reliance, and uncertainty. Deep wells of resilience, coping skills and an outlook on life formed in the shadow of trauma has enabled these women to manage the impact of the virus much better than they or I expected at the start of the pandemic lockdown. However, that is not to say it has been all smooth sailing. 
This study reflects on some of the inner and external resources that supported women through this. As users of this service receive National Disability Insurance Scheme (NDIS) funding, it is valuable to reflect upon how its continued active support of users assists them and helps minimise the multiple losses and effects of the lockdown and virus.
This is a case study of one small art service being provided to women in Melbourne, Australia. It explores how COVID-19 has impacted them, some of their losses, and their desires for the future post-lockdown. Its focus is on the threads that have woven a sense of community through this service and how women who have never met each other have provided practical and emotional support to each other to alleviate some of the adverse effects of the virus. It speaks to the artist's contributions, the NDIS, and the service provided in enabling those who could have expected to be overwhelmed and severely impacted by this situation, if not to flourish during this time, at least not sink into despair and depression.
Working with Young Children in a New World Replete with Assumptions
Authors: Pulla Venkat Rao , Hergass Shiri
Published: November 2022

We lived in an assumptive world until COVID-19 told us that all forms of coziness and security seem to have vanished. By focusing on three basic assumptions about worldview, that the universe is compassionate, that the world is important, and that the world is worthy of itself, we explore how to cope with trauma and sophisticated emotional information. We focus on teachers and their relationship with young children as both groups try to develop strategies to handle their own trauma—teachers helping children cope and teachers managing their own trauma. We worked in a preschool that supports a large number of children that have experienced trauma. Our work focused on 10 teachers and 100 children. The Seasonal Model (2019) was implemented, and groups ran over a 10-week period. Outcomes showed positive trends toward helping teachers develop a deeper understanding of “big behaviours” and managing them, enabling them to help children build strategies to handle their trauma and emotions.
Additionally, outcomes showed that teachers were better equipped to handle their own trauma, whether personal or related to “taking in” the traumatic experiences of the children they were working with. Here is an attempt to knit together the assumptions of educators and young children through the language of art and social work. A conversation is carefully re-crafted around the concept of the assumptive world. This attempt also intends to see how else we can build a world with those who have survived and help them attain their well-being whilst dealing with and coming to terms with their losses.
Cytotoxic Potential of Bioactive Compounds From Aspergillus Flavus, an Endophytic Fungus Isolated From Cynodon dactylon: Experimental and Computational Approach
Authors: Kalimuthu Arjun Kumar , Parasuraman Pavadai , Panneerselvam Theivendren , Babkiewicz Ewa , Pijanowska Joanna , Mrowka Piotr , Rajagopal Gopalan , Venkatraman Deepak , Sundar Krishnan , Maszczyk Piotr , Kunjiappan Selvaraj
Published: November 2022

Endophytic fungi are a diverse group of microorganisms that colonize the inter- or intracellular spaces of plants for mutual benefits. The interactions with a host plant and other microbiomes are multidimensional and play a crucial role in the production of secondary metabolites. We screened bioactive compounds present in the extracts of Aspergillus flavus, an endophytic fungus isolated from the roots of the medicinal grass Cynodon dactylon, for its anticancer potential. Ethyl acetate extract from isolated A. flavus showed significant cytostatic effects (IC50: 16.25 μg mL−1) against breast cancer cells (MCF-7). Morphology of cells and DAPI stained nuclei along with the results of flow cytometry annexin V/PI assay suggested apoptosis to be the main process leading to cells’ death. While investigating the mechanism that triggers apoptosis, we found that the extract of A. flavus increased ROS generation and caused loss of mitochondrial membrane potential of MCF-7 cells. To identify the metabolites that might be responsible for the anticancer effect, the extract was examined using gas chromatography-mass spectrometry (GC-MS). Interestingly, nine phytochemicals were found to have potential inhibitory effects of anti-apoptotic protein (Bcl-2) in the breast cancer cells. In the in silico molecular docking and molecular dynamics simulation studies revealed that two compounds: 2,4,7-Trinitrofluorenone and 3alpha, 5alpha-Cyclo-ergosta-7,9(11),22t-triene-6beta-ol exhibited significant binding affinities (-9.20, and -9.50 Kcal mol-1, respectively) against Bcl-2 along with binding stability and intermolecular interactions of its ligand-Bcl-2 complexes. Overall, the study found that the endophytic A. flavus from C. dactylon contains plant-like bioactive compounds that have a promising effect in breast cancer.
Towards a Just Monetary and Economic System
Authors: Belouafi Ahmed
Published: November 2022

The paper draws attention and opens the debate on major societal issues that concern not only Muslims but human societies, at large, because of their profound implications, afflictions, and their present and future transitive dimensions. The paper discusses two major issues that have attracted a great deal of attention in the recent past: wealth and income disparities, and global indebtedness. Four remedies have stressed upon and/or proposed to eradicate and/or lessen some of the burdens of these problems have been thoroughly examined. These are: - Stripping commercial banks of their power to create money out of thin air (i.e., Ex Nihilo). Thus, reviving financial reform in line with the spirit of the call for the “Establishment of a National Bank [in England]” in the 1820s by the renowned British economist David Ricardo (1772-1823). The Bank of England was a private commercial entity at that time. - Prohibiting of ‘harmful’ speculation activities in financial and economic transactions and/or imposing hefty taxes on transactions relating to such activities. The implementation of such a policy requires and clear-cut distinction between the ‘harmful’ and ‘non-harmful’ speculative activities in financial and non-financial markets. - Levying adequate and fair taxes on the wealthiest upper class at the global scene. Calls for such a policy is on rise in the past few years. For instance, “Speakers at the European Development Days summit in Brussels, [in 2017], said that a just tax system should be “at the heart” of the development debate, and that more transparency is needed to ensure that companies pay their fair share. Tax avoidance schemes used by multinational companies, such as moving profits to tax havens, result in global losses of around $650 billion a year in tax receipts — with developing countries losing $200 billion, according to a study from the International Monetary Fund”, (Edwards, 2017; Crivello et al., 2015, p. 21) - Establishing a neutral legislative and tax regimes for different modes of financing. Thus, providing ‘a level playing field’ for equity and debt modes of financing due to the current biasness of the tax regimes to debt-based financing instruments as it has been documented in various studies carried out by the IMF, the European Commission, and other international prominent bodies.
Simultaneous Assessment of Reactive Oxygen Species and Radiosensitization of Brain Cancer Cells using Nanoparticle Spectroscopy
Authors: Djam Honour , Kramer Harrison , Thiegs Caleb , Hubbard Anne , Walter Yohan , Merrick Michael , Mimlitz Michael , Weeder Catherine , Akhter Haris , Jacob Megha , Khaparde Gargee , Abraham Ashley , Bamesberger Joe , Ekpenyong Andrew
Published: November 2022

Nanoparticle-mediated radiation therapy (NPRT) is an emerging modality for radiosensitization of highly resistant cancers such as brain cancers. This is due to the ability of specific nanoparticles (NPs) to increase physical dose deposition and subsequent direct damage to cells and DNA within their local vicinity, through enhanced generation of reactive oxygen species, ROS. Here, we report the successful use of PEGylated (biocompatible) core-shell quantum dots (QDs) and carbon quantum dots (CQDs) to simultaneously enhance and assess ROS generation while radiosensitizing highly radioresistant brain cancer cell lines: T98G and U87 Glioblastoma cells. Relative peak fluorescence intensity ratio calculations and average intensity comparisons show highly significant (***p<0.001) enhancement of ROS generation, for 5 Gy and 20 Gy irradiation, applied using a Faxitron Cell Irradiator. By quantifying post-radiotherapy cell attachment, proliferation, migration, cell survival and cell death using electric cell-substrate impedance sensing and clonogenic assays, we demonstrate potentially improved in vitro radiotherapeutic outcomes for brain cancer cells radiosensitized using PEGylated CdSe/ZnS QDs and CQDs.
Autonomic Function Recovery in Post-Covid-19 Young Adults After Immunization: An Observational Follow up Case-control Study
Authors: Freire Ana Paula Coelho Figueira , Amin Shaan , Lira Fabio Santos , Morano Ana Elisa von Ah , Pereira Telmo , Coelho-e-Silva Manuel J. , Caseiro Armando , Christofaro Diego Giulliano Destro , Ribeiro-Santos Vanessa , Marchioto Júnior Osmar , Pinho Ricardo A , Silva Bruna Spolador de Alencar
Published: November 2022

Coronavirus disease 2019 (COVID-19) has detrimental multi-system consequences. Symptoms may appear during the acute phase of infection, but literature on long-term recovery of young adults after mild-to-moderate infection is lacking. Heart rate variability (HRV) allows observation of autonomic nervous system (ANS) modulation post SARS-CoV-2 infection. Additionally, physical activity (PA) helps improve ANS modulation, where investigation of PA influence on ANS recovery is vital to reduce risk and severity of symptoms. Clinicians may use this research to aid development of non-medication interventions. At baseline, 18 control (CT) and 20 post-COVID-19 (PCOV) participants were observed where general amnamnesis was performed, followed by HRV and PA assessment. 10 CT and 7 PCOV subjects returned for follow-up (FU) evaluation 6 weeks after complete immunization (2 doses) and assessments were repeated. Over the follow-up period, decrease in sympathetic (SNS) activity (mean heart rate: p=0.0024, CI=-24.67- -3.26; SNS index: p=0.0068, CI=-2.50- -0.32) and increase in parasympathetic (PNS) activity (mean RR:p=0.0097, CI=33.72-225.51; PNS index: p=0.0091, CI=-0.20-1.47) were observed. At follow-up, HRV was not different between groups (p>0.05). Additionally, no differences were observed in PA between moments and groups. This study provides evidence of ANS recovery after SARS-CoV-2 insult in young adults over a follow-up period, independent of changes in PA.
Avoidable Intensive Care Resource Use of Unvaccinated COVID-19 Patients: Interpretation and Policy Implications
Authors: Joffe Ari , Milburn Chris
Published: November 2022

We aim to use a recently published research study as an example in order to demonstrate how data can be misinterpreted and result in deriving misleading policy implications. Bagshaw et al wrote that unvaccinated patients with COVID-19 in Alberta, Canada “had substantially greater rates of ICU admissions, ICU bed days, and ICU related costs than vaccinated patients did. This increased resource use would have been potentially avoidable had these unvaccinated patients been vaccinated.” The authors in Bagshaw et al then concluded that their findings “have important implications for discourse on the relative balance of increasingly stringent public health protection (restrictions), including mandatory vaccination policies, and the sustainability and function of health system infrastructure and capacity during the ongoing COVID-19 pandemic.” Here we show the following. First, the effect of vaccination on intensive care admissions were grossly over-estimated. Second, an effect of vaccination on access to acute care and on all-cause excess deaths was grossly over-stated. Third, policy implications were overstated and at best unclear. Overall, the data cannot support what Bagshaw et al called “increasingly stringent public health protection (restrictions), including mandatory vaccination policies”.
A Mixture of Chemicals Found in Human Amniotic Fluid Disrupts Brain Gene Expression and Behavior in Xenopus laevis
Authors: Leemans Michelle , Spirhanzlova Petra , Couderq Stephan Chi , Le Mével Sébastien , Grimaldi Alexis , Duvernois-Berthet Evelyne , Demeneix Barbara Ann , Fini Jean-Baptiste
Published: November 2022

Thyroid hormones (THs) are essential for normal brain development, influencing neural cell differentiation, migration, and synaptogenesis. Multiple endocrine-disrupting chemicals (EDCs) are found in the environment, raising concern for their potential effects on thyroid hormone signaling and the consequences on neurodevelopment and behavior. While most research on EDCs investigates the effects of individual chemicals, human health may be adversely affected by a mixture of chemicals. Many compounds belonging to a wide range of chemical classes have been identified as EDCs, notably those affecting thyroid hormone signaling. We hypothesized that embryonic exposure to a mixture of chemicals (containing phenols, phthalates, pesticides, heavy metals, perfluorinated -, polychlorinated, and polybrominated compound) commonly found in the human amniotic fluid could lead to altered brain development to assess its effect on thyroid hormone signaling and neurodevelopment in an amphibian model (Xenopus laevis), highly sensitive to thyroid disruption. Newly hatched tadpoles were exposed for eight days to either TH (thyroxine, T4 10nM) or the amniotic mixture (1x concentration) and gene expression was analyzed in the brains of exposed tadpoles using both RT-qPCR and RNA sequencing. Results indicate that whilst some overlap on TH-dependent genes exist, T4 and the mixture have different gene signatures. Immunohistochemistry showed increased proliferation in the brains of T4-treated animals whereas no difference was observed for the amniotic mixture. Further, we demonstrated diminished tadpoles’ motility in response to T4 and mixture exposure. As the individual chemicals composing the mixture are considered safe, these results highlight the importance of examining the effects of mixtures to improve risk assessment
Machine Learning Brings Vast Core-Analysis Legacy Data to Life
Authors: Carpenter Chris
Published: November 2022

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This article, written by JPT Technology Editor Chris Carpenter, contains highlights of paper OTC 31419, “Bringing Huge Core-Analysis Legacy Data to Life Using Machine Learning,” by Siti N.F. Zulkipli, SPE, Benard Ralphie, and Jamari M. Shah, SPE, Petronas, et al. The paper has not been peer reviewed. Copyright 2022 Offshore Technology Conference. Reproduced by permission.

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Among the sources of subsurface data, rock and fluid analyses stand out as the best means of directly measuring subsurface properties. The implication of modeling this data into an organized data store means better assessment of economic viability and producibility in frontier basins and the capability to identify bypassed pay in old wells that may not have rock material. The complete paper presents agile technologies that integrate data management, data-quality assessment, and predictive machine learning (ML) to maximize company asset value with legacy core data.

Introduction

The complete paper integrates data gathering, data filtering, the connecting of scattered data, and the building of useful knowledge models using legacy core data from various operating assets. This integration is achieved by a data quality check (QC) work flow and ML to improve the definition of reservoir rock properties that affect field development and asset management. ML and deep-learning capabilities have been implemented to predict critical reservoir properties based on qualified legacy data.

The work flow is aimed at bridging gaps in areas with limited core data coverage, reducing subsurface uncertainty and risk, and accelerating project delivery. In addition, data-prediction accuracy can be improved with ML applications as new data become available.

Phase I: Data Preparation and Verification

In this stage, more than 60,000 data points are gathered from 327 wells and grouped into different categories such as routine core analysis, special core analysis, geology, and rock mechanics. Leveraging on best practices in laboratory core analysis and subject-matter expert (SME) expertise, 88 QC rules are generated to delineate the data, identify outliers, and classify the data into good quality (labeled as 0), data requiring further QC (1), and rejected data (2). The generated QC rules target various rock properties such as porosity, permeability, capillary pressure, electrical properties, relative permeability, and rock mechanics. QC-rule implementation is an iterative process in which, after the initial screening, the rules are further optimized and enhanced to assist data classification based on practical experiences. These QC rules are needed because some observed data errors are related to data tabulation and incorrect naming.

A total of 1,826 relevant variables, generated by different vendors, was extracted during QC-rule creation. These variables had to be merged in the QC process, which reduced the number of variables to 240.
Assisted Cement Log Interpretation Using Machine Learning
Authors: Viggen Erlend Magnus , Singstad Bjørn-Jostein , Time Eirik , Mishra Siddharth , Berg Eirik
Published: November 2022

The Assisted Cement Log Interpretation Project has used machine learning (ML) to create a tool that interprets cement logs by predicting a predefined set of annular condition codes used in the cement log interpretation process.

The development of a cement log interpretation tool speeds up the log interpretation process and enables expert knowledge to be efficiently shared when training new professionals. By using high-quality and consistent training data sets, the project has trained a model that will support unbiased and consistent interpretations over time.

The tool consists of a training and a prediction tool integrated with cased-hole logging interpretation software. By containerizing the code using an “API First” design principle (API: application programming interface), the applicability of this add-on tool is broad. The ML model is trained using selected and engineered features from cement logs, and the tool predicts an annular condition code according to the cement classification system for each depth segment in the log. The interpreters can easily fetch a complete cement log interpretation prediction for the log and use that as a template for their final interpretation. The ML model can easily be retrained with new data sets to improve accuracy even further.

To improve cement log interpretation consistency in the industry, the code will be made available as open source.
HER2 expression in peritoneal dissemination of high-grade serous ovarian carcinoma: a comparative study of immunohistochemical reactivity using four HER2 antibodies
Authors: Yeo Min-Kyung , Kim Sup , Yoo Heon Jong , Suh Kwang-Sun , Kim Kyung-Hee
Published: November 2022

Objective: Most high-grade serous ovarian carcinomas (HGSOCs) involving the peritoneum are highly aggressive. Epidermal growth factor receptor 2 (HER2) is aberrantly activated and a therapeutic target in a variety of solid cancers. However, the role of HER2 in HGSOC is still controversial. The HER2 status of a tumor is based on cytoplasmic membrane staining of an intracellular domain (ICD)-specific HER2 antibody. In this study, we compared four anti-HER2 antibodies in an immunohistochemical study of HGSOC with peritoneal dissemination.
Methods: HER2 expression was assessed in peritoneal disseminated HGSOC specimens from 38 patients by immunohistochemistry using four different anti-HER2 antibodies [an ICD antibody (clone A0485), an extracellular domain (ECD) antibody (clone SP3), and two antibodies recognizing HER2 phosphorylated at tyrosine 877 or 1248 (pHER2Y877 and pHER2Y1248)]. HER2 gene amplification was accessed by chromogenic in situ hybridization (CISH).
Results: The antibodies showed HER2 positivity as follows: 31.6 % of cases (12/38) with A0485, 26.3 % (10/38) with SP3, 7.9 % (3/38) with pHER2Y877, and 21.1% (8/38) with pHER2Y1248. Fifteen of 38 (39.5 %) cases were positive with at least one of the four HER2 antibodies, and two cases tested positive with all four antibodies. Differences in the HER2 expression using the pHER2Y877 assay and the A0485 or SP3 assay were observed (p = 0.012 and p = 0.039, respectively). HER2 gene amplification was detected in 3/19 cases.
Conclusion: All four HER2 antibodies could be used for patient selection for anti-HER2 therapies. These findings raise the possibility of anti-HER2 therapeutic strategies for HGSOC with peritoneal dissemination.
Effect of cepharanthine on the stemness of lung squamous cell carcinoma Based on Network Pharmacology and Bioinformatics
Authors: Liu Bo , Deng Jian-xiong
Published: November 2022

Background. Lung squamous cell carcinoma (LUSC) has poor survival prognosis and few clinical treatment options. We urgently need to explore new therapeutic drugs in clinical practice. Cepharanthine (CEP), which has been shown to have anticancer effects in several tumors, but the mechanism of CEP in treating LUSC has not been reported.
Methods. SwissTargetPrediction, PharmMapper and GeneCards were used to identify targets of CEP and LUSC. Further topological analysis was used to obtain hub genes via Cytoscape. Molecular docking was carried out to verify the combination of CEP with hub targets. Based on bioinformatics, we first analyzed the expression and survival of hub targets in LUSC, and further analyzed the correlation between hub targets and cancer stemness, immune cell infiltration and tumor mutation burden (TMB).
Results. A total of 41 targets were identified. Further topological analysis identified 6 hub genes: AURKA, CCNA2, CCNE1, CDK1, CHEK1 and PLK1. Molecular docking analysis showed that CEP had stable binding to all these 6 target proteins. In-depth bioinformatics analysis of these 6 targets showed that high expression of these targets were positively correlated with cancer stemness index, and negatively correlated with tumor infiltrating immune cells. In immune subtype analysis, the expressions of these targets were significantly decreased in inflammatory tumors. In addition, we also found that the expressions of these targets were positively correlated with TMB.
Conclusion. Based on multidisciplinary analysis, we preliminarily identified potential targets of CEP for LUSC treatment and suggested that CEP may play a role in regulating LUSC stemness.
Grow Newtonian rigid inertia into parameter repetitiveness memory equivalent bio-inertia over the “super-simultaneousness” of quantum mechanics for growth turnover selection inheritance
Authors: Lai Yi Yu
Published: November 2022

Inversion energy is defined as parameter-against-gravity-internal-fluctuation, the non-simultaneousness in correlated internal fluctuations is quantizing time. Modified Newtonian Three Laws are, first: cosx = sinx = ; second: + ; third: Wavelength = L, frequency = n . Bio-systems are topological spaces that can process input objects into inversion energy for entropy-control by repetitiveness memory, the capability of equivalent procured inversion energy with memorized trigonometric repetitiveness by quantizing time is bio-inertia. Evolution grows the trigonometric folding equivalent capacity of a topological space. Schrödinger equation has only quantized energy but hasn’t quantized time thus inducing quantum collapse. We then define in vivo conditions to grow over the “super-simultaneousness” of conventional quantum to reverse collapse for lifespan. Originating from the quantum scale difference between Planck regions and surface tension regions, bio quantum duality grows in vivo cross folded-surface tension region flow. Life relies on trigonometric negentropy procured from elastic entropy generation ground states and physically inherit by bio quantum growthturnover selection.
Multi-UAVs cooperative coverage search for non-convex region without prior information
Authors: Li Minghan , Xia Xuewen
Published: November 2022

An Unmanned Aerial Vehicle (UAV) is considered as a suitable equipment in coverage search missions due to its small size, high maneuverability, low cost and portability. However, due to the non convexity of reality coverage tasks, the complexity is further increased, a single UAV can not effectively perform the task due to its shortcomings in endurance. Therefore, using a group of UAVs in coverage search missions has become a research hotspot in recent years. In this paper, a Multi-UAVs cooperative coverage algorithm for non-convex region call CSANCR is proposed to deal with non-convex tasks. The strategy adopts the path planning algorithm based on differential evolution algorithm for prior planning, the information interaction between UAVs is carried out through the network, and a Distributed Model Predictive Control (DMPC) is used for cooperative control and path optimization among UAVs. A dynamic reward function is designed to evaluate the quality of the solution according to the change of UAV state.The experimental results show that the strategy can achieve high coverage and low energy consumption index under the constraints of collision avoidance.
PACS: 0000, 1111 2000 MSC: 0000, 1111
Rockfall Feature Investigation and Kinematic Simulation Based on Nap-of-the-Object Photogrammetry and GIS Spatial Modeling
Authors: li xude , Liu Fuzhen , Zhao Li , Deng Na , Chen Long , pan Jingshen , Tang Guoqiang
Published: November 2022

Chaya County, as one of the important towns in the "Three Rivers Region" in southeastern Tibet, is the key target for future expansion and development. Disaster risk investigation and research are the primary task of county expansion and development. UAVs have been widely used in disaster surveys by virtue of their ability to rapidly acquire rich and diverse geospatial data. However, due to the comprehensive influence of terrain environment, GPS positioning accuracy, and image acquisition and processing methods, the positioning accuracy and resolution acquired from the 3D model and DSM data are difficult to guarantee its reliability. In this case, when interpreting rock mass characteristics, there will be limitations such as inaccurate extraction of joint and fissure information, inability to reflect rock mass surface roughness, and even incapacity to identify fine joints. Meanwhile, the resolution of terrain data will also affect the reliability of the simulation results of rockfall motion characteristics. Therefore, a new image acquisition method and modeling idea are summarized in this paper, and obtains a real-world 3D model with a positioning accuracy of less than 5 cm and DSM data with sub-centimeter resolution for a slope in the study area by this way. According to these data, a rock mass characteristic survey was completed, and a 3D numerical simulation of the potential rockfall movement characteristics was performed in GIS. At present, there are three potential rockfall areas in the study area, with a volume of about 2690m³. Affected by factors such as freeze-thaw erosion, differential weathering, faults, and unfavorable structural plane combinations, rockfall disasters may continue to occur in the future. The simulation results show that after the high-level rockfall occurs, the movement trajectory presents a diversion phenomenon, and the side of the township road is more threatened than the side of the G349 National Highway. The results of this paper have important reference value for disaster prevention and mitigation for the expansion of Chaya County, and can also provide important basic data for the research on fault activity, landform formation and evolution in Changdu and surrounding areas.
Majorana corner states on the dice lattice
Authors: Mohanta Narayan , Soni Rahul , Okamoto Satoshi , Dagotto Elbio
Published: November 2022

Lattice geometry continues providing exotic new topological phases in condensed matter physics. Exciting recent examples are the higher-order topological phases, manifesting via localized lower-dimensional boundary states. Moreover, flat electronic bands with a non-trivial topology arise in various lattices and can hold a finite superfluid density, bounded by the Chern number $C$. Here we provide a general route to analyze the topological properties of flat bands in the superconducting state. We argue that the topological superconductivity induced in a flat band with $C=n$ is of order $n$ and the associated boundary Majorana states have a complex structure when $n>1$. As example, we show that an attractive interaction in the dice lattice, that exhibits flat bands with $C=2$, gives rise to second-order topological superconductivity with mixed singlet-triplet pairing. The second-order nature of the topological superconducting phase is revealed by the zero-energy Majorana bound states at the lattice corners. These findings suggest that flat bands with a finite Chern number provide feasible platforms for inducing topological superconductivity of various orders.
WITHDRAWN: Investigation of Seasonal Metal Pollution in Karacaören II Dam Lake Sediment Samples by X-ray Fluorescence Technique
Authors: Apaydın G. , Koksal O. K. , Cengiz E. , Şirin M. , Baltaş H. , Tıraşoğlu E.
Published: November 2022

Sediment samples collected from twelve different notes of the Karacaören II Dam Lake were analysed for seasonal metal pollution in this study. Energy dispersive X-ray fluorescence spectrometry was used to measure the amount of metal in soil samples. Metal concentrations found in the sediments were used to generate the geoaccumulation index and enrichment factor expressions. The results were compared seasonally to values at the local, state, and international levels. Copper, zinc, lead, arsenic, nickel, chromium, and mercury element content ratios (in ppm) measured in sediments in all seasons were determined to be 42–96, 53–78, 11–14, 4–7, 233–244, and 611–711, respectively. The elemental content of the sediments and their contamination levels are also discussed.
A novel HOXD13 mutation causes synpolydactyly and promotes osteoclast differentiation by regulating pSMAD5/p65/c-Fos/RANK axis
Authors: Zhang Lishan , Fang Ziqi , Cheng Guangdong , He Mengting , Lin Yanliang
Published: November 2022

The mutations of HoxD13 gene have been involved in synpolydactyly (SPD), and the polyalanine extension mutation of HoxD13 gene could lead to SPD in mice. In this study, a novel missense mutation of HoxD13 (NM_000523: exon2: c.G917T: p.R306L) was identified in a Chinese family with SPD. The mice carrying the corresponding HoxD13 mutation were generated. The results showed that the homozygous mutation of HoxD13 also caused SPD, but heterozygous mutation did not affect limbs development, which was different from that of SPD patients. With the increasing generation, the mice with homozygous HoxD13 mutation presented more severe syndactyly. Western blotting showed that this mutation did not affect HOXD13 expression, suggesting that this mutation did not result in haploinsufficiency. Further analysis demonstrated that this homozygous HoxD13 mutation promoted osteoclast differentiation and bone loss, and enhanced the expression of osteoclast-related genes RANK, c-Fos, and p65. Meanwhile, this homozygous HoxD13 mutation elevated the level of phosphorylated SMAD5 (pSMAD5). Co-immunoprecipitation verified that this mutation attenuated the interaction between pSMAD5 and HOXD13, suggesting that this mutation released more pSMAD5. Inhibition of pSMAD5 reduced the expression of RANK, c-Fos and p65 despite in the mutation group. In addition, inhibition of pSMAD5 repressed the osteoclast differentiation. ChIP assay confirmed that p65 and c-Fos could bind to the promoter of RANK. These results suggested that this novel HoxD13 mutation promoted osteoclast differentiation by regulating smad5/p65/c-Fos/RANK axis, which might provide a new insight into SPD development.
Differential Associations between Trauma Types and Borderline Personality Disorder from the Perspective of Emotion Dysregulation
Authors: Yuan Yan , Lee Hyunji , Newhill Christina , Eack Shaun , Fusco Rachel , Scott Lori
Published: November 2022

Background: Borderline Personality Disorder (BPD) is characterized by pervasive instability in a range of areas including interpersonal relationships, self-image, and affect. Extant studies have consistently identified significant correlations between childhood trauma and BPD. While exploring this trauma-BPD link, a number of cross-sectional studies commonly emphasize the role of emotion dysregulation (ED). A better understanding of the association between trauma and BPD is essential in formulating early, effective intervention approaches, and in addressing varied adverse impacts.
Methods: We analyzed a subset of data collected for a larger community-based longitudinal study. Given that our current focus on trauma and ED, only those participants who completed the baseline assessment measures of trauma and ED (N=144) were included for the primary analyses. We conducted stepwise multivariate linear models to examine the differential relationships between BPD features, ED, and specific traumas. A path analysis with latent factors using the structural equation modeling (SEM) method was performed to test the indirect effect from trauma to BPD features via ED.
Results: Linear regression models revealed that emotional abuse (relative to other trauma types) was significantly associated with high BPD features. The SEM, by constructing direct and indirect effects simultaneously, showed that (1) ED partially mediated the path from trauma to BPD features; and (2) trauma played a complex role in which the direct effect remained significant even after accounting for the indirect effect through ED.
Conclusions: Our results highlight a most consistent association between emotional abuse and trauma, indicating its unique role in understanding BPD features in the context of childhood adversity. Further, shame-related negative appraisal and ED were found critical when examining the association between trauma and BPD, possibly providing promising treatment targets for future practices.
Transforming growth factor β (TGF-β) pathway in immunopathogenesis of multiple sclerosis (MS); molecular approaches
Authors: Esmaeilzadeh Abdolreza , Mohammadi Vahid , Elahi Reza
Published: November 2022

Multiple sclerosis (MS) is an acute demyelinating disease with an autoimmune nature, followed by gradual neurodegeneration and enervating scar formation. Dysregulated immune response is an important dilemma contributing to the pathogenesis of MS. The role of chemokines and cytokines, such as transforming growth factor-β (TGF-β), have been recently highlighted regarding their altered expressions in MS. TGF-β has three isoforms, TGF-β1, TGF-β2, and TGF-β3, that are structurally similar; however, they can show different functions. All three isoforms are known to induce immune tolerance by modifying Foxp3+ regulatory T cells. Nevertheless, there are controversial reports concerning the role of TGF-β1 and 2 in the progression of scar formation in MS, while these proteins are also known to improve oligodendrocyte differentiation and have shown neuroprotective behavior, two cellular processes that suppress the pathogenesis of MS. TGF-β3 shares the same properties but is less likely to contribute to scar formation and its direct role in MS remains elusive. To develop novel neuroimmunological treatment strategies for MS, the optimal strategy could be the one that causes immune suppression, induces neurogenesis, stimulates remyelination, and prevents excessive scar formation. Therefore, regarding its immunological properties, TGF-β could be an appropriate candidate for this; however, contradictory results of previous studies have questioned its role and therapeutic potential in MS. In this review article, we provide an overview of the immunopathogenesis of MS, the role of TGF-β in this process, related clinical and animal studies, and the treatment potential of TGF-β in MS by emphasizing the role of different TGF-β isoforms.
Criticality and Heterogeneity as General Principles to Optimize Performance for Spiking Cameras
Authors: Jin Chao , Wang Chen , Qi Xin , Wang Zhijun , He Yuan , Yu Lianchun
Published: November 2022

As a bioinspired sensor with high temporal resolution, the spiking cameras have enormous potential in real applications, yet it remains largely unknown how to improve their performance. In this study, we showed that the dynamic range of neuronal networks could be maximized jointly by critical dynamics resulting from balanced excitatory and inhibitory synaptic currents and the heterogeneity in the resting potentials of neurons in the networks. We then built a spiking camera to demonstrate that its performance, characterized by the peak signal-to-noise ratio (PSNR) and the structural similarity index measure (SSIM), could be optimized if the critical dynamics and heterogeneity were included in its core module. we argue that criticality and heterogeneity can serve as basic optimization principles of neuromorphic device design to improve their performance.
Systemic Paracoccidioidomycosis in a Patient With Enzymatic Myeloperoxidase Deficiency and Acute Lymphoblastic Leukemia: Case Report
Authors: Hoyos Sebastian , Quintero Cristián Camilo Agudelo , Lozano Diana Mercedes , Naranjo Luis Eduardo Buitrago
Published: November 2022

Background:
Paracoccidioidomycosis is a systemic fungal infection that is potentially fatal, and the most prevalent of its kind in Latin America. The predisposition to infection appears to be related to abnormalities in cellular immunity, given its low prevalence in endemic regions. The role of myeloperoxidase deficiency has not been elucidated.
Case presentation:
We present a case of 48-year-old female patient with acute lymphoblastic leukemia, stem cell transplant candidate, who developed a fever with lymphadenopathy and lung nodules, consistent with paracoccidioidomycosis infection, in whom a myeloperoxidase deficiency was later discovered. The treatment of the hematologic malignancy had a good impact solving the enzymatic deficiency and antifungal therapy achieve controlling the infection.
Conclusions:
This case lays out the possible association between acute leukemia, an alteration in neutrophil function (needed to fight fungal infections) and an infection due to Paracoccidioides brasiliensis.