bluuebunny/crossref_metadata_2025 huggingface dataset:
“More Worries Kept on Coming and Coming”: An Interpretative Phenomenological Analysis of How Early Adolescent Girls Experience Emotional Symptoms
Authors: Demkowicz Ola , Humphrey Neil , Holmes Joshua
Published: July 2020

Objectives: We sought to explore the subjective ways that at-risk early adolescent girls experience and make sense of emotional symptoms, characterised by depressive and anxious feelings. Research indicates higher rates of emotional symptoms and disorders among girls and women, and recent evidence indicates increasing prevalence among adolescent girls, warranting exploration of subjective experiences.Methods: Interpretative phenomenological analysis (IPA) was used to explore lived experience and sense-making. This approach aims to capture rich, in-depth insight into the way in which a small number of early adolescent girls subjectively understand and experience these types of symptoms. In-depth interviews were conducted with three early adolescent girls who described experiencing emotional symptoms and exposure to multiple sources of possible stress.Findings: Five themes were developed to capture participants’ experiences of symptoms: (a) the nature of symptoms, including differing conceptualisations of symptoms as objectified cognitive entities or an affective state; (b) symptoms are a collective mass that can grow, which can sometimes mean they go beyond one’s control; (c) symptoms as central and dominant in emotions; (d) passive experience of symptoms, whereby participants often considered themselves passive within occurrence and resolution of their symptoms; and (e) grappling with symptoms in relation to the self, which captures the separation participants created these feelings and their core identities. Conclusions: Early adolescent girls can experience symptoms as intense and at times uncontrollable, and may find it difficult to align these difficulties with their sense of self. It may be therapeutically valuable to support this group in understanding and making sense of these thoughts and feelings in order to facilitate a greater sense of control.
Patrimônio Territorial: abordagens teóricas e indicativos metodológicos para estudos territoriais
Authors: Dallabrida Valdir Roque
Published: July 2020

O patrimônio territorial é aqui concebido como o conjunto de ativos e recursos, materiais e imateriais, que se acumularam ao longo da história num determinado território, resultante de processos históricos de construção e reconstrução socioeconômica e cultural, na relação com o entorno ambiental. Inclui tanto os elementos herdados do passado longínquo, quanto os que se sobrepõem ao território constantemente. Apesar de sua importância, o tema ainda é pouco estudado no Brasil e América Latina. Com o propósito de amplificar sua divulgação junto aos pesquisadores e estudantes e instigar novas investigações, recorreu-se à literatura disponível, explicitando-se as principais abordagens teóricas sobre patrimônio, patrimônio territorial e patrimonialização, incluindo, também, as visões críticas. Adicionalmente, são apresentadas sugestões de questões que possam motivar novas investigações. Conseguiu-se acessar dezenas de publicações, sendo que as principais contribuições teóricas provêm de autores que se filiam à linha de pensamento da Escola Territorialista Italiana. Com base nas concepções dos autores referenciais, pode-se concluir que tomar o patrimônio territorial como ponto de partida e diretriz no planejamento ou elaboração de estratégias localizadas de desenvolvimento é seguir no caminho para superarmos análises setoriais e avançarmos rumo a um retorno ao território, ou seja, adotarmos uma abordagem territorial de desenvolvimento.
Niveles de hemoglobina y su relación con la ingesta de proteínas de alto valor biológico y hierro en gestantes
Authors: Echenique-Yupanqui Mario , Espinoza-Bernardo Sissy
Published: July 2020

En el Perú la anemia en gestantes es de 29,6%, siendo un indicador de malnutrición y de problemas de salud. Una dieta con nutrientes en calidad, cantidad y proporción adecuada puede reducir las complicaciones durante el embarazo. El objetivo fue determinar los niveles de hemoglobina y su relación con la ingesta de proteínas de alto valor biológico y hierro en gestantes que acuden al Hospital de Chincha de EsSalud. Estudio analítico, transversal y correlacional. Muestreo aleatorio simple conformado por 104 gestantes que se atendieron por consulta externa en el Servicio de Nutrición del Hospital de Chincha de EsSalud. Los datos fueron recolectados por una entrevista y una encuesta de frecuencia de consumo de alimentos. El estadístico empleado fue el análisis de regresión lineal bivariado y múltiple. Se encontró 35% de gestantes anémicas, 48% y 59% de gestantes con ingesta deficiente de proteínas de alto valor biológico y hierro, respectivamente. Hubo correlación alta y estadísticamente significativa entre los niveles de hemoglobina con la ingesta de proteínas de alto valor biológico y hierro (r=0,88; r2=0,78; p<0,001). Se concluyó que los niveles de hemoglobina tienen relación directa y fuerte con la ingesta de proteínas de alto valor biológico y hierro en gestantes.
Los médicos generales y la salud mental en la pandemia por COVID-19
Authors: Montes-Arcón Pablo Salomón , Campo-Arias Adalberto
Published: July 2020

En lo corrido del milenio hemos sido testigos de varios desafíos para el orden social y la estabilidad de la comunidad en el ámbito de salud mental con el brote de enfermedades infecciosas1. El nuevo coronavirus (COVID-19) se extendió rápidamente, de China a más de 200 países y es responsable de una pandemia sin precedentes de neumonía aguda2.
CENTRALIDADE E ÁREA DE INFLUÊNCIA DE SÃO PAULO DO POTENGI/RN NA REDE URBANA REGIONAL
Authors: Tavares Edseisy , Gomes Dina , Porfírio Escarlaty
Published: July 2020

A rede urbana do Rio Grande do Norte tem apresentado modificações quanto ao papeis e funções das cidades em todos os níveis da hierarquia urbana. Neste sentido, o objetivo deste trabalho é analisar a centralidade de São Paulo do Potengi/RN no período atual na rede de influência regional. Para tanto, foram identificados os principais fluxos desse centro urbano nos estudos do IBGE, realizado em 2008 e analisados os usos do território que mais movimentam fluxos nesse centro urbano entre 2018 e 2019. A pesquisa contemplou um estudo teórico-conceitual e empírico, abordando discussões sobre a urbanização do território, rede urbana e usos do território e teve como variáveis de análise os sistemas técnicos de telecomunicações e transportes e redes de comércio e serviços. Constatamos que novas redes de interações territoriais estão sendo estabelecidas com fluxos que expandiram sua área de influência.
O CONTEXTO GEOMORFOLÓGICO E A DINÂMICA MORFOMÉTRICA DA BACIA HIDROGRÁFICA DO RIO TENENTE AMARAL/MT
Authors: De Lourdes Lazzarotto Cabral Ivaniza , Ribeiro de Jesuz Cleberson
Published: July 2020

A bacia hidrográfica do rio Tenente Amaral faz parte do sistema São Lourenço, desaguando no Pantanal Setentrional. Assim, propõe-se apresentar a análise das formas de relevo para a referida área a partir de uma proposta metodológica que utilize como suporte os estudos de materiais bibliográficos e bancos de dados geoespaciais. Esta área faz parte das unidades morfoesculturais da Depressão Interplanáltica de Rondonópolis e do Planalto e Chapada dos Guimarães. Na primeira unidade predominam os processos de recuo da superfície planáltica com destaque para feições geomorfológicas de escarpas erosivas, rampas coluvionares, superfícies erodidas/rebaixadas, relevo residual e vales encaixados, e na segunda têm-se eventos de erosão superficial (em meio agropecuário/vegetação nativa primária e/ou secundária), vales encaixados, sistemas de voçorocamentos em cabeceiras de drenagem e superfícies com feições trapeizoidais.
INFLUÊNCIA SÓCIOECONÓMICA DA EXISTÊNCIA DOS GRUPOS DE POUPANÇA E CRÉDITO ROTATIVO NO DISTRITO DE MARRACUENE, PROVÍNCIA DE MAPUTO-MOÇAMBIQUE
Authors: Rosário Nelson Maria , Cumbe Amélia
Published: July 2020

O presente artigo avalia a influência socioeconómica da existência dos grupos de poupança e crédito rotativo no distrito de Marracuene. Para o alcance dos objectivos preconizados no estudo, optou-se pelo uso da abordagem qualitativa e quantitativa, tendo sido inquiridos 30 integrantes dos Grupos de Poupança e Crédito Rotativo existentes no distrito de Marracuene e entrevistados dois técnicos afectos ao Serviço Distrital de Actividades económicas de Marracuene que assistem os grupos existentes. Dentre vários aspectos positivos que podem se elencar dos Grupos de poupança e crédito rotativo (GPCR), a mais importante é o fato de os grupos de Poupança e Crédito constituírem em verdadeiras escolas de gestão financeira e de promoção das poupanças para as comunidades. Os resultados do estudo mostraram que as famílias inserida nos GPCR melhoraram as suas condições sociais bem como económicas, são os casos de acesso a saúde, educação, habitação e capital para iniciar novos negócios. Assim sendo, foi possível concluir-se que a existência de Grupos de Poupança e Crédito Rotativo no distrito de Marracuene, tem impactos sociais e económicos positivos.

Palavras-chave: Influência socioeconómica, Poupança e Crédito Rotativo, e Marracuene.
GESTÃO TERRITORIAL E O PROGRAMA DE INFRAESTRUTURA E SERVIÇOS (PROINF) NO MÉDIO SERTÃO DE ALAGOAS
Authors: Antero da Silva Juliana , Pereira Santos Priscila
Published: July 2020

O objetivo geral desta pesquisa foi analisar a gestão territorial no Médio Sertão de Alagoas sob a perspectiva das ações dos Projetos de Infraestrutura e Serviços (PROINF). Este estudo tem como delineamento os seguintes procedimentos metodológicos, a saber: pesquisa bibliográfica, pesquisa documental e pesquisa de campo. Observou-se maior participação dos atores sociais nas plenárias do Colegiado que tratavam das chamadas para o PROINF. Possivelmente, o PROINF é a chave de atração do Colegiado, no entanto, como força que atrai também pode apresentar força inversa. No Colegiado, o espaço de discussão torna-se arena de poder na tomada de decisões. O interesse de determinado grupo é evidenciado, o que possivelmente tende a excluir os grupos ou associações não participantes. A proposta de coletividade é sucumbida por um processo perverso e desagregador.

Palavras-chave: Agricultura familiar; PROINF; Gestão territorial; Médio Sertão; Alagoas.
LOS GUARANÍ Y LOS CHANÉ EN EL AHORA. CHAMANISMO, RELIGIÓN Y ETNOPOLÍTICA EN EL NOROESTE ARGENTINO
Authors: Flores Maria Eugenia
Published: July 2020

El objetivo del presente artículo es indagar sobre el pasado y el presente de los líderes religiosos guaraní y chané en el territorio del actual Norte Argentino. Por un lado, se indagará sobre lo que fue el sistema chamánico del complejo chiriguano-chané, descrito en estudios etnohistóricos, y, por otro lado, se pretende analizar los procesos de yuxtaposición de estos sistemas chamánicos con los sistemas religiosos cristianos, trayendo a colación algunos casos etnográficos actuales de líderes políticos y religiosos indígenas y evangélicos, que manejan las artes de la curación. Por último, se presentará un análisis sobre las emergencias espirituales, las mediaciones culturales y las transfiguraciones religiosas entre los pueblos amerindios contemporáneos.
Single Nucleotide Polymorphisms in Colitis-Associated Colorectal Cancer: A Current Overview with Emphasis on the Role of the Associated Genes Products
Authors: Makaro Adam , Fichna Jakub , Włodarczyk Marcin
Published: July 2020

Colitis-Associated Colorectal Cancer (CA-CRC) is one of the most severe complications of
Inflammatory Bowel Disease (IBD) and constitutes the cause of death in 10-15% of patients. The risk
ratio for carcinogenesis depends on numerous factors, such as the extent of intestinal inflammatory lesions
and the duration of the disease. CA-CRC is a major problem of today's gastroenterology and
colorectal surgery due to the fact that the incidence and prevalence of IBD are increasing. In this review,
we discussed the current state of knowledge regarding genetic differences between sporadic
CRC and CA-CRC, especially pertaining to the chromosomal instability mechanism (CIN). In order to
explain CA-CRC molecular basis, we have analyzed the data from studies regarding the correlations
between CA-CRC and the presence of Single Nucleotide Polymorphisms (SNPs). Further focus on the
role of associated proteins has emphasized the role of NF-κB signaling as the main link between inflammation
and carcinogenesis during the course of IBD.
Have We Learnt all from IMPROVE-IT? Part I. Core Results and Subanalyses on the Effects of Ezetimibe Added to Statin Therapy Related to Age, Gender and Selected Chronic Diseases (Kidney Disease, Diabetes Mellitus and Non-Alcoholic Fatty Liver Disease)
Authors: Fras Zlatko , Mikhailidis Dimitri P.
Published: July 2020

IMPROVE-IT (IMProved Reduction of Outcomes: Vytorin Efficacy International Trial) was
a randomized clinical trial (including 18,144 patients) that evaluated the efficacy of the combination of
ezetimibe with simvastatin vs. simvastatin monotherapy in patients with acute coronary syndrome
(ACS) and moderately increased low-density lipoprotein cholesterol (LDL-C) levels (of up to 2.6-3.2
mmol/L; 100-120 mg/dL). After 7 years of follow-up, combination therapy resulted in an additional
LDL-C decrease [to 1.8 mmol/L, or 70 mg/dL, within the simvastatin (40 mg/day) monotherapy arm
and to 1.4 mmol/L, or 53 mg/dL for simvastatin (40 mg/day) + ezetimibe (10 mg/day)] and showed an
incremental clinical benefit [composite of cardiovascular death, nonfatal myocardial infarction, unstable
angina requiring rehospitalization, coronary revascularization (≥30 days after randomization), or nonfatal
stroke; hazard ratio (HR) of 0.936, and 95% CI 0.887-0.996, p=0.016]. Therefore, for very high cardiovascular
risk patients “even lower is even better” regarding LDL-C, independently of the LDL-C
reducing strategy. These findings confirm ezetimibe as an option to treat very-high-risk patients who
cannot achieve LDL-C targets with statin monotherapy. Additional analyses of the IMPROVE-IT (both
prespecified and post-hoc) include specific very-high-risk subgroups of patients (those with previous
acute events and/or coronary revascularization, older than 75 years, as well as patients with diabetes
mellitus, chronic kidney disease or non-alcoholic fatty liver disease). The data from IMPROVE-IT also
provide reassurance regarding longer-term safety and efficacy of the intensification of lipid-lowering
therapy in very-high-risk patients resulting in very low LDL-C levels. We comment on the results of
several (sub) analyses of IMPROVE-IT.
Have We Learnt all from IMPROVE-IT? Part II. Subanalyses of the Effects of Ezetimibe Added to Statin Therapy on Selected Clinical and Laboratory Outcomes, Cost-Effectiveness, Guidelines, and Clinical Implications
Authors: Fras Zlatko , Mikhailidis Dimitri P.
Published: July 2020

In this second part of the review of the IMProved Reduction of Outcomes: Vytorin Efficacy
International Trial (IMPROVE-IT), the findings in relation to patients with stroke, the ACS phenotype,
history of coronary artery bypass graft surgery, heart failure, concurrent polyvascular atherosclerotic
cardiovascular disease (ASCVD) and diabetes mellitus, and different levels of expression of selected
cardiovascular biomarkers, are discussed. The combination therapy was proven safe, and drug discontinuation
rates were not increased by adding ezetimibe. Since both statins and ezetimibe are now almost
globally generically available, it can be concluded that for secondary prevention of ASCVD, adding
ezetimibe to high-intensity statin therapy further reduces low-density lipoprotein cholesterol (LDL-C)
and cardiovascular risk, cost-effectively.
Gut Microbiota and Gender in Autism Spectrum Disorders
Authors: Kushak Rafail I. , Winter Harland S.
Published: July 2020

Gender dimorphism in autism spectrum disorders (ASD) is well known; however, the
reasons for gender differences in autism are poorly understood. There are several hypotheses that
might explain male prevalence in ASD, including increased levels of androgens, “extreme male
brain,” and a combination of elevated levels of prenatal testosterone in conjunction with prenatal
stress. In this comprehensive review, differences in the gut microbiome and metabolome in humans
and animals are described to explain gender differences in individuals with ASD, effects on behavior
and social interactions and the impact of antibiotics, probiotics and fecal transplants. The bidirectional
relationship between sex hormones and intestinal microbiota could also be relevant. Such
interactions have been described in autoimmune diseases, but thus far, are not implicated in ASD.
Since intestinal microbiota may affect behavior, it is possible that the prevalence of ASD in boys
may be associated with more significant changes in the intestinal microbiome than in affected girls.
Clinical Profile, Severity Pattern and Socio-demographic Risk Factors of Acute Lower Respiratory Tract Infection (ALRTI) in Children in Enugu, Nigeria
Authors: Chinawa Awoere , Chinawa Josephat , Nduagubam Obinna , Chukwu Bartholomew , Nwokoye Ikenna , Amadi Oge , Ndu Ikenna , Aronu Ann , Eze Joy
Published: July 2020

Introduction:

Acute lower respiratory tract infection (ALRTI) is a major public health
problem that causes significant morbidity and mortality and is the main reason for utilization of
health services among children.

Obectives:

The study aimed to evaluate the clinical profile, severity pattern, and sociodemographic
risk factors of ALRTI in hospitalized children under the age of five years in two tertiary hospitals in
South East Nigeria.

Materials and Methods:

This is a cross-sectional study of children aged two months to five years in
two teaching hospitals in the country. They were evaluated for ALRTI, focusing on their clinical
profile and socio-demographic risk factors.

Results:

Two hundred children presented with features of ALRTI, mostly pneumonias and
bronchiolitis. ALRTI occurred throughout the year with a peak in October. The majority had severe
disease and risk factors for severity were infancy, type of ALRTI, presence of comorbidity and lack
of measles vaccination or vitamin A supplementation, and exposure to wood smoke. Fast breathing
was the most sensitive symptom, while breathlessness was the most specific for ALRTI.

Conclusion:

Bronchopneumonia and bronchiolitis are the most common ALRTI in under-five age
children with bronchopneumonia occurring in severe forms. Poor breastfeeding, infancy, poor rate of
immunization and exposure to biomass smoke are all risk factors for severity.
Computed Tomography in the Diagnosis of Ascites: The Role of Fluid Attenuation Values
Authors: Ştefan Paul-Andrei , Lebovici Andrei , Csutak Csaba , Mihu Carmen Mihaela
Published: July 2020

Background:

Intraperitoneal fluid accumulations are a common matter in current clinical
practice, being encountered by most medical and surgical fields.

Objective:

To assess ascites fluid with attenuation values in the form of Hounsfield units (HU) in
order to determine a non-invasive differentiation criterion for the diagnosis of intraperitoneal collections.

Methods:

Sixty patients with known intra-peritoneal collections who underwent computed tomography
(CT) for reasons such as tumor staging, post-surgical follow-up or other indications, were
retrospectively included in this study. All subjects had a final pathological analysis of the fluid collections.
Two radiologists measured the attenuation values for each collection. The averaged values
were used for comparing benign and malignancy-related ascites (MRA), bland and hemorrhagic
ascites and infected and noninfected fluid collections by consuming the Mann–Whitney U test. Also,
the receiver operating characteristic analysis was performed for the statistically significant results
(P<0.05), and the area under the curve (AUC) was calculated.

Results:

Attenuation values could differentiate between benign and MRA (P=0.04; AUC=0.656;
sensitivity, 65.52%; specificity, 71.43%) but failed to distinguish between bland ascites and ascites
with hemorrhagic component (P=0.85), and between infected and noninfected fluid collections
(P=0.47).

Conclusion:

Although the results are statistically significant, the substrate of differentiation between
benign and MRA ascites cannot be clearly stated. As being the first study to investigate this
issue, it opens the way for other researches in the field to determine the dynamics of imaging quantitative
measurements according to the fluid’s pathological features.
Self-Assembled Amphotericin B Pharmacosome-Like Vesicles Derived from Lipid-Based Microtubes: A Model Carrier to Further Explore
Authors: Salerno Claudia , Cuestas Maria L. , Manco Karina , Chiappetta Diego A , Lucangioli Silvia E.
Published: July 2020

Background:

Self-assembled drug delivery systems are of much interest since they can be
produced by simple low cost and solvent-free procedures. Pharmacosomes are supramolecularstructured
nanocarriers with benefits for drug stability and targeting delivery. Amphotericin B (AmB)
still remains an important agent for the treatment of invasive mold infections, e.g invasive aspergillosis,
although the challenge for new formulations is still prevailing due to high rates of toxicity.

Objective:

We have previously reported the incorporation of AmB into 12-hydroxystearic acid lipidbased
microtubes (MTs) for topical use, herein we report the ability of AmB-MTs to self-assemble into
vesicles upon dilution.

Methods:

AmB-MTs with different drug concentrations (1, 3, 5 mg/ml) were prepared, and size determination
was carried out for different dilutions. Morphology was evaluated by microscopy. In vitro
cytotoxicity was evaluated in Vero cells and in vitro activity against Aspergillus fumigatus and Aspergillus
flavus was assessed.

Results:

AmB-MTs closed upon dilution to form vesicles ranging from 200 nm to 1μm. AmB MIC
(Minimum inhibitory concentration) for both Aspergillus species was 0.0625 and 0.125 μg/ml for dispersion
and reconstituted lyophilized, respectively.

Conclusion:

AmB pharmacosome-like vesicles are smaller structures than MTs may thus be favourable
for other delivery routes. We assume that this kind of pharmacosomes-like carrier is a promising
model for the obtention of new vesicular carriers based on lipid MTs.
Preparation and Evaluation of Polymeric Microparticles of Human Recombinant IL-1 Receptor Antagonist by Spray Drying
Authors: Ubhe Anand , D’Souza Gerard G.M.
Published: July 2020

Background:

Formulating protein drugs into delivery systems with high drug loading is particularly
challenging. Another major hurdle for formulation processes generally used for protein drugs
is their scalability. In this article, we present the application of spray drying to prepare polymeric microparticles
of human recombinant IL-1 receptor antagonist (IL-1 ra).

Objective:

The objective of this study was to formulate polymeric microparticles entrapping a therapeutic
protein, human recombinant IL-1 ra using a spray drying process.

Methods:

IL-1 ra was formulated using three polymers viz. gelatin, pectin, and sodium alginate by using
a spray drying process to produce polymer entrapped drug microparticles. A single drug to polymer
ratio was used in the three drug-polymer formulation combinations. The prepared microparticles were
evaluated for morphology by scanning electron microscopy, average particle size by dynamic light scattering
and drug entrapment efficiency by ELISA.

Results:

Microparticles of three drug-polymer combinations were prepared using the Buchi B-90 spray
dryer. The morphology of the three types of polymeric microparticles was found to be uniform by
scanning electron microscopy. The average particle size for the three formulations ranged from 1 to 2.2
μ with a low standard deviation implying narrow particle size distribution. The drug loading efficiency
ranged from 62 to 90 % W/W for the three formulations.

Conclusion:

The presented study demonstrates the feasibility of using spray drying to prepare morphologically
uniform polymer entrapped protein drug microparticles with high drug entrapment efficiency.
Method Validation for the Determination of Carbamazepine in Spiked-saliva Using HPLC-UV for Therapeutic Drug Monitoring Application
Authors: Wibowo Ari , Ningrum Vitarani D.A. , Ilhamy Rahma N.
Published: July 2020

Background::

Carbamazepine has been used in the treatment of bipolar disorder,
both in acute mania and maintenance therapy, particularly in developing countries. Not only
its interaction with various drugs and auto-inducer nature, but the narrow therapeutic
range of carbamazepine also makes monitoring necessary to guarantee the adequacy of its
safety and therapeutic concentration. To date, the most common biological specimen used
for therapeutic drug monitoring (TDM) purposes is still plasma, but saliva can become an
alternative biological matrix since its level in saliva strongly correlates with carbamazepine
plasma concentration.

Objective::

This study validated the bioanalytical method parameters used for carbamazepine
in spiked-saliva in accordance with the Food and Drug Administration (FDA) criteria
in the Guidance for Industry Bioanalytical Method Validation.

Methods:

HPLC-UV detector was employed at 285 nm λ with methanol: water: glacial
acetic acid (65:34:1) as the mobile phase and C8 as the stationary phase (4.6x150 mm; 5 μm).

Results::

The linearity test in a range of 0.0 - 5 μg/mL carbamazepine concentration resulted
in a correlation coefficient of 0.999 with 0.20 μg/mL LoD, 0.30 μg/mL LLoQ, and 0.61
μg/mL LoQ. The coefficient of variation and 0iff in the selectivity, accuracy, and precision
parameters remained below 20%, indicating fulfillment of the criteria for a bioanalytical
method, while the average % recovery was more than 90%.

Conclusion::

The currently-developed bioanalytical method has fulfilled the stipulated validation
criteria to be used for determining carbamazepine concentration in spiked-saliva as
an alternative method for relative bioequivalence studies or TDM application in a clinical
setting.
Lifestyle and Health promotional Guidelines in Irritable Bowel Syndrome
Patients from the Viewpoint of Persian Medicine
Authors: Jamalizadeh Hossein , Ahmadi Bijan , Setayesh Mohammad , Sharififar Fariba , Ansari Mehdi , Shahesmaelli Armita , Tajadini Haleh
Published: July 2020

Introduction:

Irritable Bowel Syndrome (IBS) is a chronic disorder. Considering its unknown etiology, the aim
of IBS treatment is to control symptoms, and most patients are dissatisfied with current treatments. The World Health Organization (WHO) has emphasized, in its latest announcement in this regard, on the safe and effective use of traditional
and complementary medicine in the health structures of countries
The aim of the present study was to investigate the lifestyle of IBS patients from the perspective of Persian Medicine.

Methods:

This is a library study. At first symptoms of IBS were first studied in databases and reference books of classical
medicine and their Persian equivalents were extracted from PM sources. Then, we explained the total etiologies that were
discussed for the occurrence of the causes, with respect to the principles of health care in PM. finally collected information was categorized and analyzed.

Results:

Iranian physicians have presented their views on health preservation and disease prevention in the form of the six
core principles. The influence of diet and lifestyle, sleep disturbances, eating habits, and physical activity have been found
to be effective in causing this disease.

Discussion:

Many of the guidelines given by PM for preservation and restoration of health are incorporated into lifestylerelated topics. Some of these recommendations and guidelines such as sleep, exercise, regular meals, and treatment of
mental disorders have been supported with a number of new studies.

Conclusion:

Introducing PM strategies to control the symptoms or treatment of IBS may provide researchers with new
clues.
Elementos para una propuesta de política pública en gestión comunitaria del agua
Authors: Núñez Marín Raúl Fernando , Valencia Serrano Felipe
Published: July 2020

El presente artículo expone la necesidad de una política pública en Colombia con enfoque de derechos humanos, que promueva y fortalezca la gestión comunitaria del agua en las zonas rurales del país, dado que esta se ha visto amenazada por el olvido gubernamental y el modelo neoliberal de libertad económica regulada desarrollado en la Ley 142 de 1994. Con este propósito se empleó una metodología hermenéutica y analítica, para la proposición de categorías que permitieran la comprensión histórica y jurídica de las formas de gestión pública, privada y comunitaria del recurso hídrico. Así, los resultados que se obtuvieron permitieron presentar un panorama sobre la gestión comunitaria del agua y la carga regulatoria que deben asumir los acueductos comunitarios en Colombia. Tema que demanda una respuesta estatal estructurada y centrada en el reconocimiento del derecho fundamental al agua, el cumplimiento de las obligaciones que se derivan de instrumentos jurídicos nacionales e internacionales de derechos humanos y la afirmación de las comunidades campesinas y rurales como sujetos colectivos de derechos que tienen una relación especial con el territorio y el recurso hídrico, por lo que deben ser consultados en el diseño e implementación de esta política pública.
Remote Care for Caregivers of People With Psychosis: Mixed Methods Pilot Study (Preprint)
Authors: Romm Kristin Lie , Nilsen Liv , Gjermundsen Kristine , Holter Marit , Fjell Anne , Melle Ingrid , Repål Arne , Lobban Fiona
Published: July 2020

BACKGROUND

A reduced availability of resources has hampered the implementation of family work in psychosis. Web-based support programs have the potential to increase access to high-quality, standardized resources. This pilot study tested the Norwegian version of the Relatives Education and Coping Toolkit (REACT), a web-based United Kingdom National Health Service program in combination with phone-based support by trained family therapists.

OBJECTIVE

We investigated how the program was perceived by its users and identified the facilitators and barriers to its clinical implementation.

METHODS

Relatives of people with psychosis were offered access to REACT and to weekly family therapist support (with 1 of 2 trained family therapists) for 26 weeks. Level of distress and level of expressed emotion data were collected at baseline and after 26 weeks using the Family Questionnaire and the Relatives Stress Scale. Both family therapists and a subset of the relatives were interviewed about their experiences after completing the program.

RESULTS

During the program, relatives (n=19) had a median of 8 (range 4-11) consultations with the family therapists. Postintervention, there was a significant reduction in stress and in expressed emotions in the relatives of people with psychosis. Interviews with the relatives (n=7) and the family therapists (n=2) indicated the following themes as important—the intervention turned knowledge into action; the intervention strengthened the feeling of being involved and taken seriously by the health services; and management support and the ability for self-referral were important, while lack of reimbursement and clinician resistance to technology were barriers to implementation.

CONCLUSIONS

The service was found to offer a valued clinical benefit; however, strategies that aim to engage clinicians and increase organizational support toward new technology need to be developed.
ANALISIS KESTABILAN MODEL PENYEBARAN PENYAKIT TUBERKULOSIS DENGAN LAJU INFEKSI TERSATURASI (STABILITY ANALYSIS OF TUBERCOLOSIS SPREAD DISEASES MODEL CONSIDERING SATURATED INFECTION RATE)
Authors: Saputra Handika Lintang , Sutimin Sutimin , Sutrisno Sutrisno
Published: July 2020

This paper deals with the analysis of tuberculosis disease spread model with saturated infection rate and the treatment effect. We analyze the dynamical behavior of the model to observe the stability peroperty of the model’s equilibrium points. The Routh-Hurwitz Theorem is used to analyze the local stability peroperty of the free disease equilibrium point whereas Transcritical Bifurcation principle is used to analyze the local stability property of the endemic equilibrium pont. The result show that the local stability property of the equilibrium points is depending on the basic reproduction number value calculated by the next generation matrix (NGM). When the basic reproduction number is less than 1, the free disease equilibrium point is locally asymptotically stable, and when it is greater than 1, the endemic equilibrium point is locally asymptotically stable. Numeric simulation results were presented to describe the evolution of the dynamical behavior and to understand the treatment effectiveness for the tuberculosis disease of the population. From the simulation results, it was derived that the treatment in the infected subpopulation had a better result than the one in latent.
Dengue Incidence and Climatic Factors
Authors: Loffredo Leonor de Castro Monteiro , Júnior Rodolpho Telarolli , Figueiredo Walter Manso , Segantini Bruno Lian Sartore , Maurencio Christian Wagner , Galego Fabiano Santos , Borges João Ramalho , Benevides Társis Eschaquetti
Published: July 2020

Introduction: This study was carried out to analyze the temporal evolution of the incidence of dengue in Araraquara-SP, Brazil, from 2012 to 2016, correlating the incidence with temperature and pluviometry. Methods: It was a cross-sectional design. The monthly number of cases from 2012 to 2016 was collected in the datafile of the Special Health Service of Araraquara-SESA of USP. Climatic variables related to temperature and rainfall were obtained from the websites of Agritempo and Department of Water and Electric Power, respectively. Statistical planning included incidence rates, and the tendency from 2012 to 2016, and it was studied the correlation between the number of dengue cases and each one of the climatic variables, considering the time-lag concept. Results: The incidence rates were 52.68, 376.52, 737.39, 3,660 and 809.48 per 100,000 inhabitants. Significant correlations were observed between the number of dengue cases and climatic variables after 2-4 months for high temperature and after 1-4 months for rainfall. Conclusions: The city faced an epidemic of dengue in 2015. It was identified the time lag in which hot weather and rain favored the occurrence of new cases: 2 to 4 months later for high temperature, and 1 to 4 months later for rainfall.
Daya Terima, Zat Gizi, dan Nilai Energi Roti Tawar Anti- Diabetes dengan Penambahan Sari Mengkudu (Morinda citrifolia L.)
Authors: Anggriani Rista , Laelatunisa Nurul , Rizky Nikmatul , Arum Rachmadhanti
Published: July 2020

White bread is a popular food product in Indonesia which is dominated by carbohydrate content. To improve its function, the noni juice which has phytochemical compounds of the alkaloid group was added. However, noni has a very strong aroma, which makes this noni rarely processed. This study aims to analyze the nutritional content, energy value, and organoleptic test of white bread added with noni juice. This research used a descriptive experimental design that the data is compared with SNI No 01-3840-1995 of white bread (Standard Nasional Indonesia = Indonesia Standard Requirement). Noni juice is added by four levels (0, 50, 150, 250ml). The results found that the more noni juice added would cause the addition of flour used, thereby increasing the calories per serving. In addition, the addition of noni juice causes an increase in brown color and aroma but decreases the tenderness, and sweetness of white bread.
Kajian Fitokimia dan Aktivitas Antioksidan Jamur Tiram Putih (Pleurotus ostreatus)
Authors: Wahyudi Vritta Amroini , Octaviana Laurent , Sutrisno Sutrisno
Published: July 2020

Processed products derived from mushrooms have been found and enjoyed by the community. One of the edible mushrooms used as traditional medicinal ingredients andalso, functional food is oyster mushrooms. Although oyster mushrooms have often been studied even using sophisticated instruments, some chemical laboratories that do not yet have sophisticated instruments still need literature data in the process of separation until pure isolates are obtained. This research was conducted to be the solution. The study uses descriptive methods by collecting data from the results of extraction, characterization, identification, and testing of antioxidant activity. Characterization includes retention factor (Rf) from elution of thin-layer chromatography (TLC), determination of melting point (to determine the purity of isolates), and solubility test (to determine the nature of polarity). The identification of isolates was done by analyzing the results of Infrared and UV-Vis spectra. Phytochemical studies of white oyster mushrooms can be done based on secondary metabolite screening, separation by extraction, and fractionation using organic solvents. Based on phytochemical screening, white oyster mushrooms are known to positively contain flavonoids, alkaloids, and terpenoids. The crude extract had an absorbance of 0.669 at 274 nm, the chloroform fraction had an absorbance of 0.827 at 267 nm, and pure isolates had an absorbance of 0.628 at 282 nm. A spectrum with a maximum wavelength of> 210 nm indicates a conjugated system. The longer the conjugated system, the more inactive in the UV region of 200- 360 nm (UV) but more active in the 360-729 nm (Visible) region (Worsfold et al, 2019). UV-Vis spectrum of methanol extract, chloroform fraction, and pure isolate showed wave crests in the region> 210 nm so that all three were shown to have a conjugated system.
Even Order Ranked Set Sampling with Auxiliary Variable
Authors: Tayyab Muhammad , Noor ul-Amin Muhammad , Hanif Muhammad
Published: July 2020

Even order ranked set sampling (EORSS) is a novel proposed ranked set sampling scheme connected with an auxiliary variable correlated with the study variable. This scheme quantifies only the one sampling unit which is at even position from each ranking set by employing specific criteria. The performance of the ratio estimator under EORSS is compared to its contemporary estimators in simple random sampling (SRS), ranked set sampling (RSS), median ranked set sampling (MRSS) and quartile ranked set sampling (QRSS) exploiting the same number of quantified units. The simulation results proved that EORSS is an efficient alternative sampling scheme for ratio estimation than SRS, RSS, MRSS and QRSS.
To commemorate the 75th anniversary of Victory in the World War II: how has digitalization changed our attitude to history
Authors: Lvova Olga V.
Published: July 2020

Problem and goal. The actual problem of digitalization means, degree and consequences of influence on fostering public and personal opinion in society is considered in the article. The purpose of the study was to show that digitalization is qualitatively changing some aspects of social life. Methodology. Determination of digitalization means, degree and consequences of influence on some aspects of social life was carried out by analysis of work results of some sites/portals devoted to events of World War II. Results. Digitalization nowadays is a process being quickly spread all around the world. It covers a wide range of human activities: business, industry, agriculture, education, healthcare, culture and social life. The process being very new, complex and challenging demands developing of a high (state) level strategy such as Industrie 4.0 - one of ten projects for State Hi-Tech Strategy of Germany up 2020 or Digital Economy of the Russian Federation. Moreover it becomes obvious that digitalization influences not only production but also society. In 2016 Japan released concept Society 5.0 - a large plan of social transformations. Interesting and remarkable results in fostering some aspects of social life were also reached in the Russian Federation during preparation of Great Victory 75th anniversary celebration. Conclusion. It is demonstrated that massive digitalization of personal archives (photos, documents, family/participant of events stories, eyewitness accounts) as well as access to archived data of state institutions and possibility to translate all information for free has fostered qualitatively new personal and social attitude to remarkable historical events.
Development of ICT competence in high school students when teaching physics using digital laboratories
Authors: Kornilov Viktor S. , Khanina Irina A.
Published: July 2020

Problem and goal. Currently, to school education in Russia is given a lot of attention, both from state structures and from the Ministry of Education of the Russian Federation. Federal State Educational Standards of secondary general education of the Russian Federation define high requirements for the level of training of schoolchildren. In modern conditions of the information society, the school education system is designed to prepare students who form a fundamental system of subject knowledge in school disciplines, develop active, creative, critical, analytical thinking, and ICT competence. Today, those students successfully study at higher educational institutions in the educational process which are widely used information and communication technologies, self-learning and shaping system of fundamental knowledge in university disciplines which are based on modern achievements of world science. Methodology. The development of ICT competence in high school students in teaching physics will depend on success rate of: improving the goals, objectives and content of teaching physics using digital laboratories together with educational Internet resources; implementing didactic principles of teaching physics using digital laboratories together with educational Internet resources, as well as forms, methods and tools for teaching physics using digital laboratories together with educational Internet resources. Results. At laboratory workshops in physics in the conditions of using digital laboratories together with educational Internet resources, high school students acquire the skills to apply modern computer technologies. High school students gain experience in analyzing the results of experiments on various physical processes and phenomena using digital laboratories together with educational Internet resources. High school students acquire in-depth knowledge not only of subject knowledge in physics, but also of the potential of digital laboratories and information technologies. Such knowledge, skills and abilities allow high school students to develop ICT competence. Conclusion. Developed in the process of teaching physics in the conditions of joint use of digital laboratories and educational Internet resources, ICT competence will allow high school students to be a successful student after graduation, entering a higher educational institution.
Hybrid environments for training engineering students the basics of working with geodetic equipment
Authors: Dudysheva Elena V. , Solnyshkova Olga V.
Published: July 2020

Problem and goal. The article describes an approach to solving the actual problem of identifying effective and approved by students blended learning tools in the initial stages of working with equipment for engineering education courses. The goal of the research was to study the applicability of hybrid environments of simplified configuration for learning work with geodetic equipment based on interactive virtual educational tools and students' mobile devices in the Novosibirsk State University of Architecture and Civil Engineering (Sibstrin). Methodology. A variant of hybrid laboratories with a virtual component and a variable (on-site or mobile) physical component is quite new for pedagogical research. The physical component is important when learning geodetic equipment since stationary devices are studied at university laboratories when portable analogs are used in real geodetic practice. The virtual component of a hybrid environment during initial work with engineering equipment can be represented by a set of multimedia educational tools that simulate the operation of engineering instruments and devices with a high degree of interactivity which available on one online platform for a specific engineering course. Results. The study found that the presented configuration of the hybrid environment is effectively applicable for initial work with geodetic equipment and is approved by students both during laboratory work in an on-site stationary laboratory, as well when using portable equipment and mobile devices in geodetic practice. Conclusion. For the initial stages of training students for working with geodetic equipment, a hybrid learning environment configuration is proposed based on interactive virtual educational tools and mobile devices which is an affordable and functional solution for engineering universities. Virtual e-learning tools can be accumulated on the site with online support for a separate engineering course and supplemented by means of distance interaction and cooperation of the lecturer and students. The hybrid environment can be used for initial training when working in a stationary laboratory or for conducting a professional business game or individual practical tasks on the ground with portable geodetic equipment.
USO DE ANIMAIS COMO ALTERNATIVA NO TRATAMENTO PALIATIVO: UMA REVISÃO DE LITERATURA
Authors: Canadas Costa Maria Carolina , Monteiro de Paula Gabriela , Santana Bianca , Dias Lopes Martins Marcela , Figueiredo de Brito Resende Rodrigo
Published: July 2020

A terapia assistida por animais (TAA) é a modalidade terapêutica onde o animal é a parte principal do tratamento, com supervisão profissional, objetivando promover a melhora social, emocional, física e/oucognitiva de pacientes humanos.  Este artigo visa identificar, através de uma revisão de literatura, os benefícios da utilização da TAA na saúde humana, assim como as espécies usadas nas modalidades de terapia. Os resultados apontaram a possibilidade de implantação da TAA em configurações diversas como hospitais, casas de repouso, clínicas ou escolas e demonstraram o potencial benéfico dessa intervenção para a reabilitação física, mental e emocional.Palavras-Chave: Terapia assistida por animais; Paliativo; Zooterapia.  ABSTRACTAnimal-assisted therapy (TAA) is the therapeutic modality where the animal is the main part of the treatment, with professional supervision, aiming to promote the social, emotional, physical and / or cognitive improvement of human patients. This article aims to identify, through a literature review, the benefits of using TAA on human health, as well as the species used in the modalities of therapy. The results pointed out the possibility of implementing TAA in different configurations such as hospitals, nursing homes, clinics or schools and demonstrated the beneficial potential of this intervention for physical, mental and emotional rehabilitation. Key words: Animal-assisted therapy; Palliative; Zootherapy.
Performance Measurement of Local Government in Indonesia: A Conceptual Study
Authors: Putri Lovina Eka , Aswar Khoirul , Ermawati
Published: July 2020

This study begins with the problem of the many Indonesia’s local governments that have not been able to compile a Government Agency Performance Accountability Report or LAKIP. This is because there are still many local governments that have not been able to measure performance with applicable standards. And therefore, many local governments still get poor grades in preparing their LAKIP. This due to several factors such as the commitment of management which is still questionable, the lack resources used to measure performance and so forth. This study aims to find out how far have local government efforts are taken to measure performance according to organizational factors of local government in Indonesia specifically in Bekasi. Through the institutional theory, this study has three objectives, to find out the effects of technical knowledge, management commitment, and resources on performance measurement. Therefore, this study contributes to provide a picture for the local government in measuring performance based on organizational factors.