bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of neoadjuvant radiotherapy on survival of non-metastatic Pancreatic Ductal Adenocarcinoma: A SEER Database Analysis
Authors: Wang Dan , Liu Chongshun , Yan Tingyu , Li Chenglong , Yang Qionghui , Xu Yang , Zhao Lilan , Pei Qian , Tan Fengbo , Güngör Cenap , Li Yuqiang
Published: April 2020

Background: Neoadjuvant radiotherapy has been shown to improve marginal negative resection and local control of Pancreatic Ductal Adenocarcinoma (PDAC). However, whether it improves overall survival (OS) in patients with non-metastatic PDAC remains controversial. Therefore, the purpose of this study was to analyze the benefits of only surgery, neoadjuvant radiotherapy, adjuvant radiotherapy, and surgery plus chemotherapy for OS in patients with non-metastatic PDAC. Methods: PDAC diagnosed by surgical histopathology in the Surveillance, Epidemiology, and End Results (SEER) database between 2004 and 2016 was selected. Kaplan-Meier analysis was used to compare the prognosis of patients with different treatments. Cox proportional risk model was used to analyze independent predictors of OS. Results: For stage T1-3N0M0 PDAC patients, the OS of surgery plus chemotherapy (HRs = 0.896, 95%CIs, 0.827-0.970; P=0.007) were significantly better than the other three treatments. For stage T1-3N+M0 patients, adjuvant radiotherapy (HRs=0.613, 95% CIs, 0.579-0.649; P< 0.001) had significantly better OS than surgery plus chemotherapy and neoadjuvant radiotherapy. For stage T4N0M0 patients, neoadjuvant radiotherapy (HRs=0.482, 95% CIs, 0.347-0.670; P < 0.001) had significantly better OS than surgery plus chemotherapy and adjuvant radiotherapy. For stage T4N+M0 patients, neoadjuvant radiotherapy (HRs=0.338, 95% CIs, 0.215-0.532; P < 0.001) had significantly longer OS than adjuvant radiotherapy and surgery plus chemotherapy. Conclusions: For patients with non-metastatic PDAC, neoadjuvant radiotherapy, adjuvant radiotherapy and surgery plus chemotherapy were superior to only surgery in OS. For patients with stage T4 non-metastatic PDAC, neoadjuvant radiotherapy had the potential to be strongly recommended over adjuvant radiotherapy and surgery plus chemotherapy. However, neoadjuvant radiotherapy failed to benefit the survival of T1-3N0M0 stage patients, and surgery plus chemotherapy was preferred. For T1-3N+M0, neoadjuvant radiotherapy had no obvious advantage over adjuvant radiotherapy or surgery plus chemotherapy in OS, and adjuvant radiotherapy was more recommended.
Visualization analysis of the characteristics of COVID-19 clinical trial
Authors: Cai Xiaoqiong , Zheng Zengliang , Su Qianmin , Huang Jihan
Published: April 2020

Objectives: This article points out the characteristics and trends of COVID-19 clinical trials through data collection, translation, mining and visualization to help in clinical trial design.Method: The registered data of COVID-19 clinical trials are gathered from the Chinese Clinical Trial Registry and ClinicalTrials.gov website transformed by Python, further demonstrated by visual tools.Results: As of 24:00 on March 28, 2020, totally 732 trial registration records have been retrieved. Overall, there are 406 (55.46%) interventional studies and 271 (37.02%) observational studies. Among interventional studies, 38.93% are randomized parallel trials, 55 (13.55%) trials considered time condition for clinical recovery as the primary endpoint, and 46 (11.33%) trials through clinical parameters and laboratory index as the primary endpoint. In the selection of intervention measures, chemical or biological agents was under the responsibility of 43.60%, of which antivirals accounted for 14.53%, antimalarials accounted for 8.87%, and 98 cases (24.14%) of studies involving Traditional Chinese Medicine or Integrated Medicine. In addition, joint network analysis of antivirals to explore the combination of drugs is further conducted.Conclusions: By Mining characteristic information of topical COVID-19 clinical trial registration, this article deserves further trial design ideas for researchers to enhance the effects.
Factors associated with anxiety and depression in rheumatoid arthritis patients: a cross-sectional study
Authors: Uda Miyabi , Hashimoto Motomu , Uozumi Ryuji , Torii Mie , Fujii Takao , Tanaka Masao , Furu Moritoshi , Ito Hiromu , Terao Chikashi , Yamamoto Wataru , Sugihara Genichi , Nakagami Yukako , Mimori Tsuneyo , Nin Kazuko
Published: April 2020

Introduction / objectives Management of anxiety and depression in rheumatoid arthritis (RA) patients is vital. Previous studies investigating this topic are conflicting, and this topic still has not been thoroughly investigated. This study aimed to clarify the association of disease activity with anxiety and depression after controlling for physical disability, pain, and treatment. Method We conducted a cross-sectional study of RA patients from the Kyoto University Rheumatoid Arthritis Management Alliance cohort. For assessments, we used the Disease Activity Score (DAS28), Health Assessment Questionnaire Disability Index (HAQ-DI), and Hospital Anxiety Depression Scale. Depression and anxiety were defined by a Hospital Anxiety Depression Scale score ≥8. We then performed multivariable logistic regression analyses. Results Of 517 participants, 17.9% had anxiety, and 28.2% had depression. The multivariable logistic regression analyses showed patients with DAS28-based non-remission had low association with anxiety (odds ratio [OR] [95% confidence interval {CI}], 0.93 [0.48–1.78]: p = 0.82) but slight association with depression (OR [95% CI], 1.45 [0.81–2.61]: p = 0.22). However, severity of the patient’s global assessment (PtGA) on DAS28 was associated with anxiety (OR [95% CI], 1.15 [1.02–1.29]; p = 0.03) and depression (OR [95% CI], 1.21 [1.09–1.35]; p < 0.01). Additionally, HAQ-DI-based non-remission was associated with anxiety (OR [95% CI], 3.51 [1.85–6.64]; p < 0.01) and depression (OR [95% CI], 2.65 [1.56–4.50]; p < 0.01). Younger patients (OR [95% CI], 0.83 [0.68–1.01]; p = 0.07) and patients not treated with methotrexate (OR [95% CI], 0.67 [0.40–1.13]; p = 0.13) tended to suffer from anxiety. Patients using steroids had a closer association with depression than those not using them (OR [95% CI], 1.66 [1.03–2.67]; p = 0.04). Conclusions Assessment of disease activity, PtGA, and HAQ-DI are important for assessing anxiety and depression in RA patients. Attention should be paid to improving PtGA and physical function.
1893-1895 İstanbul Kolera Salgınında Avrupalı Uzmanlar ve Osmanlı Devleti’nde Sağlık Modernizasyonuna Katkıları
Authors: YILDIRIM Nuran , ERTIN Hakan
Published: April 2020

Kolera salgınları, tarihte Veba, İnfluenza , Çiçek gibi tıp tarihinde önemli yer almıştır. Bu salgınlardan bakteriyel olanları antibiyotiklerin keşfi ile etkisini yitirmişken viral olanları halen insanlığı tehdit etmektedir. Günümüzde var olan Covid19 pandemisi de viral niteliği sebebiyle büyük bir korku yaratmıştır. Tarihte yer alan salgınlarda insanlığın tecrübesi bugünlere yardımcı olabilir. Bu makalede öncelikle mikrop ve bulaşma kavramlarının ortaya çıkışındaki tartışmalı süreçleri ele alınmış ve kolera ile 1831’de tanışan Osmanlı Devleti,'nde kolerayla savaşın bir bölümü anlatılmıştır. Bu savaşta başta Dr. Andre Chantemesse olmak üzere Avrupa'lı doktorların katkıları ve Osmanlı Devleti'nin modernizasyonuna katkıları incelenmiştir.
Твердые растворы AlGaInSbAs, выращенные на подложках InAs методом зонной перекристаллизации градиентом температуры
Authors: Лунин Л.С. , Лунина М.Л. , Алфимова Д.Л. , Пащенко А.С. , Пащенко О.С. , Богатов Н.М.
Published: April 2020

Growth of AlGaInSbAs solid solutions on InAs substrates from liquid phase in a temperature gradient field is discussed. There are calculated parameters and studied luminescent properties and spectral characteristics of AlGaInSbAs solid solutions isoperiodic to InAs substrates. Within the model of regular solutions, an analysis of heterophased neutrality in Al–Ga–In–Sb–As system is carried out. Regions of hermodynamic stability to spinodal decomposition of AlGaInSbAs solid solutions and isoperiodicity intervals to InAs substrate are revealed.
Investigation of Pd|HfO-=SUB=-2-=/SUB=-|AlGaN|GaN Enhancement-Mode High Electron Mobility Transistor with Sensitization, Activation, and Electroless-Plating Approaches
Authors: Lin Y.-C. , Niu J.-S. , Liu W.-C. , Tsai J.-H.
Published: April 2020

A new Pd|HfO2|AlGaN|GaN metal-oxide-semiconductor (MOS) enhancement-mode high electron mobility transistor (HEMT) is fabricated with low-temperature sensitization, activation, electroless-plating, and two-step gate-recess approaches. Experimentally, a high positive threshold voltage Vth of 1.96 V, a very low gate leakage IG of 6.3·10-8 mA/mm, a high maximum extrinsic transconductance gm,max of 75.3 mS/mm, a high maximum drain saturation current ID,max of 266.9 mA/mm, and a high ON/OFF current ratio of 7.6·107 are obtained at 300 K. Moreover, the related temperature-dependent characteristics, over temperature ranges from 300 to 500 K, are comprehensively studied. The very low temperature coefficients on gate current, drain saturation current, transconductance, and threshold voltage confirm the thermal-stable capability of the studied device. Therefore, based on these advantages, the studied Pd|HfO2|AlGaN|GaN MOS structure is suitable for the development of high-performance HEMTs. Keywords: HfO2, AlGaN|GaN, metal-oxide-semiconductor, high electron mobility transistor, electroless plating, gate recess, threshold voltage.
Электропроводность монокристаллов MnGaInSе-=SUB=-4-=/SUB=- на переменном токе
Authors: Нифтиев Н.Н. , Мамедов Ф.М. , Мурадов М.Б.
Published: April 2020

The results of studying the frequency and temperature dependences of the electrical conductivity of MnGaInSe4 single crystals on alternating electric current are presented. It was found that in the temperature range of 295.5–360 K at frequencies of 2•104–106 Hz, the regularity σ ∼ fS (0.1≤ s≤1.0) holds for electrical conductivity. It is shown that in the MnGaInSe4 single crystal the frequency dependence of electrical conductivity can be explained using the multiplet model, and the conductivity in these single crystals is characterized by a band-hop mechanism. Based on the dependences log σ ∼ 103/T, the activation energies are determined.
The MILP Model for Locating the Temporary Disaster Emergency Operation Centers in Manado Indonesia
Authors: Lasut Andre Ch. , Opit Prudensy Febreine , Rottie Ronaldo
Published: April 2020

The research proposes the Mixed Integer Linear Programming Model (MILP). This model integrates the location decisions and the number of temporary Emergency Operations Center (EOC) to be constructed. This model also focuses on events related to natural disasters, particularly floods. The researchers applied this model according to the flood scenario in five flood-prone districts in Manado, Indonesia. This research focused on maximizing the number of temporary constructed EOCs to provide the relief demands of disaster areas by considering multiple periods. The available budgets were considered as the limited constraints in this model. Therefore, the results showed that the percentage of relief demand satisfaction ranges from 28% to 100%; meanwhile, the number of the to-be-constructed temporary EOCs ranges from 0-3 for each scenario.
Energy cost analysis to station keeping for satellite formation type “TerraSAR-X - TanDEM-X”
Authors: Baranov Andrey A. , Chernov Nikita V.
Published: April 2020

The maintenance of a given configuration of the satellite formation of the “TerraSAR-X - TanDEM-X” type is considered. It is assumed that the master satellite performs only maneuvers to maintain the working orbit, and the slave satellite performs identical maneuvers to maintain the working orbit and additionally performs maneuvers to maintain a given relative configuration of the group. For the working orbit of the master satellite, the dependence of the total characteristic velocity costs for maintaining a large semi-axis, eccentricity, inclination, and their various combinations on the maintenance accuracy is studied. The minimum limits of accuracy at which maneuvering is not required are set for each of the elements. This study is general in nature and allows future missions to be planned, providing the necessary trade-offs between the accuracy of maintenance and the total characteristic speed costs that increase as maintenance accuracy increases. Also, a study of the energy costs of relative maintenance, provided that the engines of the master and slave satellites operate almost the same. It is shown that the relative maintenance requires significantly lower fuel costs, even with the accuracy required in the project. The software product developed for this study is of universal application and will be used to investigate the cost of maintaining a more complex system of four satellites, in which three satellites rotate relative to the base satellite.
Application of intelligent systems in transport
Authors: Popova Irina M. , Timofeev Sergey V. , Danilov Igor K.
Published: April 2020

The article discusses the application of intelligent transport systems for railway transport. The purpose of developing intelligent transport systems on railway transport is to strictly comply with the requirements for ensuring transport safety, reducing the level of environmental impact, significantly improving the efficiency of production activities. The software makes automatic accounting, control and analysis of fuel and energy resources consumption on the basis of the obtained data. At the same time, the dynamics of changes in fuel consumption indicators, actual and estimated costs of diesel fuel are visually reflected in real time on the monitor screen. If necessary, the system will help to identify the reasons for non-matching of these parameters and quickly contact the locomotive team to provide qualified assistance in their elimination. It is important that the hardware structure and the structure of the system software expand functionality, providing continuous operation and repair work, increasing the number of measured parameters, creating a closed fuel consumption control system in a locomotive economy. The use of these systems makes it possible to obtain an integrated assessment of the heat engineering condition of a locomotive with further scientifically substantiated correction of overhaul runs, to control its location and solve many other problems, which contributes to an increase in overhaul runs and the operational life of the locomotive.
Population ageing: demographic security threat or silver industry development potential
Authors: Zueva Anna Sergeevna , Khrolenko Tatiana Sergeevna
Published: April 2020

The authors grasped the crucial points of such demographic phenomenon as population ageing and defined the most important consequences for the economy of the country on the increase in the proportion of older persons. On the one hand, population ageing is noted as Russian demographic security threat. On the other hand, the international experience of the formation of the silver industry and focused on a certain category of older citizens economy are noticed. Prospects of development of the market of services for pensioners are estimated.
“Una especie de oriente en occidente”
Authors: Ciria Alberto
Published: April 2020

.
El Yo y su tiempo
Authors: Segura Naya Armando
Published: April 2020

.
El albor del tiempo: el arte simbólico en el pensamiento hegeliano
Authors: Luque Moya Gloria
Published: April 2020

.
Jan Patocka y la Carta 77. Antropología fenomenológica crítica y activismo de los derechos humanos
Authors: Calvo González José
Published: April 2020

RESUMENEste trabajo ofrece las claves de análisis desde la Fenomenología, por influencia de crisis antropológica y contexto político, en el compromiso de Jan Patocka en defensa de los Derechos Humanos en la antigua República de Chechoslovaquia. Declaración y Movimiento "Carta 77".PALABRAS CLAVEFENOMENOLOGÍA-ANTROPOLOGÍA-DERECHOS HUMANOS-SOCIEDAD CIVILABTRACTThis articles provides, from the point of view of phenomenology, the clues to explore Jan Patocka´s compromise in defense of human rights in the former Republic of Czechoslovakia. It includes an appendix on the Movement Carta 77 and the text of the Declaration.KEYWORDSPHENOMENOLOGY-ANTHROPOLOGY-HUMAN RIGHTS-CIVIL SOCIETY
El inconsciente: una confrontación entre Bergson y Freud
Authors: Rodríguez Serón Alicia
Published: April 2020

RESUMENAunque Bergson no ignoró las tesis de Freud ni el psicoanálisis, sin embargo las divergencias entre los dos pensadores respecto al inconsciente resultan, en gran medida, irreconciliables. El presente trabajo pretende mostrar que sus intereses en este ámbito fueron dispares: mientras Freud se interesó por el funcionamiento de los procesos inconscientes atendiendo a un punto de vista experimental más que especulativo, a Bergson le preocupa su existencia y naturaleza.PALABRAS CLAVEINCONSCIENTE – PSICOLOGÍA – BERGSON – FREUD ABSTRACTAlthough Bergson did not ignore Freud’s theses nor phychoanalysis, their divergencies concerning the unconcious are, to a great extent, irrenconciliable. The present article intentds to demostrate that ther interests were completely different : whereas Freud was interested in the unconcious processes from an experimental rather than a spectualtive point of view, Bergson was concerned with their existence and nature.KEYWORDSUNCONSCIOUS – PSYCHOLOGY – BEGSON – FREUD
La intuición en el pensamiento de Ortega
Authors: González-Sandoval Buedo José
Published: April 2020

RESUMENEste artículo constituye un estudio sobre el concepto de la intuición en el pensamiento de Ortega  y Gasset, referido a los tres órdenes de “cosas” en los que es requerida como forma de conocimiento: intuición sensible, intuición de valores e intuición del prójimo. Como intuición sensible se analiza la diversidad de significados presentes en su obra, así como una determinación genérica de dicho concepto, en conexión con el “yo ejecutivo”, que sirve de base para determinar los niveles en el proceso perceptivo, y los modos de relación del hombre con las “cosas”. En la intuición de valores, e intuición del prójimo, se determina que el planteamiento “superador” de Ortega es desplegado desde una inicial adscripción al pensamiento de Scheler, hasta posiciones más personales, que le llevan a proponer una problemática facultad “estimativa”, mediante la cual “asimila” la intuición de valores, o la “perspicacia”, y la “experiencia” como intuición del prójimo.PALABRAS CLAVEINTUICION – VALORES – PERCEPCION – ALTERIDADABSTRACTThe paper deals with the concept of intuition in Ortega y Gasset’s thought, where its reference to “things” reveals it as a form of cognition: sensible, intuition, value intuition and intuition of the other. In the first case, the different meanings of sensible intuition will be discussed and its very concept, as connecetd with the “yo ejecutivo”, wich is the base to determining the levels of the perception process and the ways man deals with “things”. Concerning the issues of value intuition and intuition of the other, from an initial assumption of Scheler’s thesis, Ortega moves on to advance a problematical “estimative” faculty, under wich value intuition, or “sharpeness”, and “experience” as intuition of the other are “assimilated”.KEYWORDSINTUITION – VALUES – PERCEPTION – OTHERNESS
De la condición política medieval: el paradigma político antes de la crisis
Authors: Rosales José María
Published: April 2020

RESUMENEl trabajo presenta algunos de los rasgos básicos de la condición política moderna. Esboza así su génesis interna desde la sacralización del ámbito político hasta los inicios de la secularización en el siglo XIII. Para ilustrar ambos momentos de la filosofía política de Santo Tomás (elaborada a la luz de los textos de Aristóteles) provee una argumentación básica que, aun siendo incompleta para reconstruir este tránsito, resulta significativamente clarificadora. PALABRAS CLAVEFILOSOFIA POLITICA MEDIEVAL-HISTORIA DEL PENSAMIENTO POLITICO- SANTO TOMAS DE AQUINOABSTRACTThe paper presents some of the basic features of the medieval political condition. This, it outlines the genesis from the sacralization of the political realm to the beginnings of secularization in the XIIIth century. To illustrate both moments, Saint Thomas' political philosophy (worked out in the ight of Aristotle's thext) provdes a significant, though incomplete, argumentative basis. KEYWORDSMEDIEVAL POLITICAL PHILOSOPHY-HISTORY OF POLITICAL THOUGHT- AQUINAS
ReactionCode: a new versatile format for searching, analysis, classification, transform, and encoding/decoding of reactions
Authors: Delannée Victorien , Nicklaus Marc
Published: April 2020

In the past two decades a lot of different formats for molecules and reactions have been created. These formats were mostly developed for the purposes of identifiers, representation, classification, analysis and data exchange. A lot of efforts have been made on molecule formats but only few for reactions where the endeavors have been made mostly by companies leading to proprietary formats. Here, we developed a new open-source format which allows to encode and decode a reaction into multi-layers machine readable code, which aggregates reactants and products into a condensed graph of reaction (CGR). This format is flexible and can be used in a context of reaction similarity searching and classification. It is also designed for database organization, machine learning applications and as a new transform reaction language.
Peranan Audit Sistem Informasi Pada Perusahaan
Authors: Sari Ranita
Published: April 2020

Dalam lingkup perusahaan, audit sistem informasi dapat ditujukan untukmengamankanaset-asetperusahaan,menjagaintegritasdata,menjagaefektivitassistem,danmencapaiefisiensisumberdaya.Mengamankanasetyangberhubungandenganinstalasisistem informasimencakup:perangkatkeras(hardware),perangkatlunak(software),manusia(people),filedata,dokumentasisistem,danperalatanpendukung lainnya.Integritas data merupakan data yang memenuhiaspekkelengkapan,baikdandipercaya,kemurnian,danketelitian
Primeras enseñanzas y reflexiones sobre la pandemia SARS-Cov-2
Authors: Chicaiza Tayupanta Jesus Onorato
Published: April 2020

La diseminación de la pandemia nos demuestra que las fronteras, nacionalidades, razas son un artificio inútil, destinado a la repartición de las áreas de influencia de las clases dominantes en el mundo. Llama la atención el mapa geo-referencial de la diseminación hacia las grandes potencias.

La premisa de “sálvese quien pueda” es inútil para enfrentar esta crisis sanitaria en la que el ser humano es el vector directo de agente infeccioso, únicamente una mirada solidaria de arriba hacia abajo y de abajo hacia arriba para ponernos en una panorámica horizontal constituye una estrategia válida para enfrentar la pandemia.
Testigos de Jehová: un desafio transfusional medico y quirurgico
Authors: Fonseca Milton , Yugsi Cuichan Marco Vinicio
Published: April 2020

Introducción: El rechazo de una transfusión de sangre y hemoderivados es una situación específica del derecho del paciente ante cualquier tratamiento y se sustenta en el principio de autonomía que se ejerce a través del consentimiento. Este derecho se pone a prueba cuando se rechaza un tratamiento vital, lo que puede causar contrariedad y dudas en la actuación del profesional. En este artículo se revisan los principios éticos, principios religiosos y los fundamentos médico-legales referentes al rechazo del tratamiento. Esta revisión persigue orientar la acción del médico que debe respetar los derechos del paciente y actuar con seguridad jurídica.

Objetivos: Identificar los fundamentos bíblicos de los testigos de Jehová para el rechazo a las transfusiones sanguíneas.

Analizar desde la perspectiva bioética el conflicto de hemotransfundir a un paciente Testigo de Jehová y su solución.

Material y Métodos: Se realizó una revisión sistemática de la literatura y de documentos de sociedades científicas dedicadas al estudió de la controversia sobre la aplicabilidad de la ética de transfusiones sanguíneas en testigos de Jehová, así como de revisiones sistemáticas, metaanálisis y estudios científicos de los últimos cinco años. Estrategia de búsqueda: Se realizaron búsquedas electrónicas en MEDLINE, EMBASE, LILACS localizados por medio de PubMed.  

Resultados: En la búsqueda inicial se localizaron 52 estudios sobre el tema, aunque se excluyeron 32 que no fueron relevantes para el objetivo de esta revisión. Finalmente se seleccionaron 12 revisiones sistemáticas, 1 estudio original, 4 metaanálisis, y 3 revisiones bibliográficas.

Conclusiones: La formación de los médicos en métodos de ahorro de sangre y la mejor comprensión de los fundamentos religiosos del problema, así como de los aspectos éticos y el marco legal en nuestro país, pueden ayudar a mejorar la comunicación entre el médico y el paciente Testigo de Jehová, evitando que se generen situaciones conflictivas que en algunos casos suponen una demora en el tratamiento que puede repercutir negativamente en la salud del paciente.
Prognostic value of vitamin-D level in non-metastatic breast cancer patients in Saudi Arabia.
Authors: Elsamany Shereef , Elemam Omaima , Zeeneldin Ahmed , Elmorsy Soha , Khatry Ahmed , Alhuthali Faisal , Alsayed Suha
Published: April 2020

Background

Deficiency of vitamin-D (Vit-D) was associated with poor survival outcome in several studies across different tumour types. The present study aims to assess the prevalence and prognostic value of Vit-D deficiency among breast cancer patients in a single institution in Saudi Arabia.

Methods

In this retrospective study, we screened patients who presented with non-metastatic breast cancer to King Abdullah Medical City, Saudi Arabia from June 2011 to December 2015. We checked baseline Vit-D level before starting systemic therapy in addition to other clinicopathological factors. Low Vit-D was defined as Vit-D level less than 30 ng /ml. The relations of Vit-D level (taking the median as the cutoff) with clinicopathological factors were assessed using Chi-Square test. Differences in survival outcome were compared using log rank test.

Results

We screened 340 patients with non-metastatic breast cancer. Baseline Vit-D levels were available for 189 patients. The median age was 50 years (range: 26- 86 years). Noteworthy, 169 (89.4%) of patients had Vit-D level <30 ng/ml with a median of 14.9 ng/ml (range: 4.0 - 45.0). Low Vit-D level (below the median) was significantly more common in premenopausal (p=0.011) and ER-negative patients (p=0.011). However, lymphovascular invasion (p=0.001), clinically (p=0.023) and pathologically positive axillary LNs (p=0.041) were linked with higher Vit- D level.

After a median follow up period of 58.2 months, 14 patients died and 40 relapsed. The 5-year disease-free survival (DFS) rates was 74.8%. The 5-year DFS rate in patients with higher Vit-D level above the median was 78.8% compared to 71.1% in patients with lower Vit-D level with no statistically significance difference (p= 0.22). The 5-year overall survival (OS) rate was 90.2%. Meanwhile, no difference in 5-year OS rate in patients with higher and lower Vit-D levels (90.3% and 89.7% respectively, p=0.6).

Conclusion

Low Vit-D level was prevalent among the studied breast cancer patients. Low Vit-D level was associated with ER-negative phenotype and premenopausal patients. Baseline Vit-D level was not significantly linked with survival outcome.
SEPARATE VIEWS ON THE RELATIONSHIP OF SPECIAL TECHNOLOGY OF LAW ENFORCEMENT BODIES AND CRIMINALISTIC TECHNIQUE
Authors: Kharaberiush I.
Published: April 2020

The correlation of forensic technology and operational technology among themselves and with special equipment of law enforcement agencies was investigated. It is shown that the constant growth of technical equipment of the law enforcement agencies of Ukraine and the presence of law enforcement structures led to the emergence of independent groups of technical means. It is emphasized that the forensic technique has a special character for its purpose, manifested in the maintenance of the main criminal process to obtain procedural information. It is proved that operational technology, as a section of the theory of operational-search activity and a component of the more general scientific concept of “special technology of law enforcement agencies”, has its own system and correlates with the forensic technique as equivalent categories of legal science. The emergence of a very important means of collecting, accumulating, storing, processing, searching and providing the necessary information is shown - automated information retrieval systems, automated specialized systems and intelligent systems that make up a separate group of special equipment. It is proved that the methodological basis of special equipment is scientifically based tactical techniques, methods and information technology. Special equipment of law enforcement agencies as an interdisciplinary branch of legal science is a system of scientific regulations and recommendations, create conditions for the development of technical tools (forensic, operational, organizational, security), as well as scientifically based methods, techniques and information technology to counter crime law enforcement agencies. The system of special equipment of law enforcement agencies consists of elements that include general provisions and branches of special equipment of law enforcement agencies. Branches of special equipment of law enforcement agencies consist of the main directions of its use in law enforcement, namely: with respect to investigative activities ― forensic technology, operational search activities ― operational technology, administrative activities ― organizational technology. It is proved that the special technique of law enforcement and forensic technology are both common and particular, respectively.
Research of Kokzhide deposits oil for increasing oil recovery by polymers
Authors: Dzhakupova Zh , Zhatkanbayeva Zh , Begaliyeva R , Salimova D
Published: April 2020

This article examines the nature of current oil recovery and knowledge of residualoil types, which is especially important when developing and introducing new ways to increase oilrecovery. In this regard, the geological characteristics, features of natural reservoirs, heterogeneity ofreservoirs and properties of oil from some fields have been studied. Physical and chemical indicatorsof oil were investigated, as well as samples of produced water from the Kokzhide deposit wereanalyzed for further research on the possibility of using polymers for enhanced oil recovery
Ферроқорытпа өндiрiсiнiң қалдықтары негiзiнде алынған катализатордың физика-химиялық сипаттамасы мен белсендiлiгi
Authors: Шоманова Ж , Сафаров Р , Носенко Ю , Жунусова К
Published: April 2020

Ақсу ферроқорытпа зауытының күл-қож қалдықтары мұнай-химияпроцестерi үшiн катализаторды дайындау үшiн пайдаланылған. Рентгеноспектралықталдау, электрондық микроскопия, оже-спектроскопия әдiстерiнiң көмегiмен орындалғанталдаулардың нәтижелерi ұсынылған. Алынған катализаторды қолдану арқылы химиялықпроцестердiң нәтижелерi ұсынылған.
Табиғи-ресурстық әлеует Oр өзенi алабының геожүйесiне техногендiк әсер ету көзi ретiнде
Authors: Бекетова А , Джаналеева Г , Атаева Г , Мендыбаев Е
Published: April 2020

Бұл ғылыми мақала Ор өзенi алабының геожүйесiне әсер ететiн техногендiккөздерiн зерттеуге арналған. Жұмыста зерттеу аймағының табиғи-ресурстық әлеуетiнiңнегiзi ретiнде геоморфологиялық жағдайлар және геожүйелердiң физико-географиялықсипаттамасы келтiрiлген. Ғылыми жұмыста антропогендiк әсер ету көздерiнiң жiктелуiберiлген. Қорытынды бойынша Ор өзенi алабының табиғи ортасына техногендiк әсер етукөздерiнiң картасы жасалынды.
Комплексная оценка геосистем бассейновых территорий
Authors: Берденов Ж
Published: April 2020

Излагаются концептуальные и методические подходы к проведениюгеоэкологической оценки геоэкосистем. Представлен анализ взаимодействия природной,хозяйственной, социальной подсистем и системы управления современными геосистемами,основанного на учете системных услуг, предоставляемых природной подсистемой ивостребованных обществом и хозяйством. По результатам исследования разработана модельтехногенной геосистемы и серии индикаторов, отражающих свойства, количественные икачественные особенности каждого блока подсистем. Структурные изменения, возникающиев геосистеме в результате антропогенной трансформации, позволяют установить качествотехногенной геосистемы и ранжировать их от устойчиво функционирующих до активнодеградирующих систем.
论水资源合理配置与可持续利用
Authors: 马 玲
Published: April 2020

伴随现代化城市建设进程的加快,水资源供需矛盾进一步凸显。与此同时,水生态环境污染恶化,更是加剧了淡水资源供应匮乏的问题。为此,全面探究水资源合理配置与可持续利用显得尤为重要。
浅谈雾霾产生的原因和危害以及治理措施
Authors: 史 娜
Published: April 2020

随着工业化的不断发展,中国经济发展迅速,同时,空气污染也逐渐加剧,造成霾霾天气。霾不仅严重影响国民经济的发展,而且严重影响国民的日常生活与身体健康。因此,雾霾防治已成为各地方政府环保部门的主要工作之一。通过查阅大量相关文献,本文简要综述了雾霾天气形成的原因及其危害,并提出相应的环保措施,为改善空气质量提出合理的建议。
Efeito do armazenamento em cultivares de feijoeiro para comercialização
Authors: Cipriano Pinto Carolina , Amaral Camila Baptista , Oliveira Carina Oliveira e , Flôres Jordana De Araújo , Lemos Leandro Borges
Published: April 2020

Os consumidores de feijão são exigentes quanto às características grão, demandando baixo tempo de cozimento, alta capacidade de hidratação e qualidade proteica. Entretanto esses atributos durante o armazenamento podem ser alterados, levando à perda de qualidade. O objetivo deste trabalho foi avaliar os atributos qualitativos de cultivares de feijoeiro do grupo comercial carioca durante o armazenamento. O delineamento utilizado foi inteiramente casualizado, em esquema fatorial 13x3, constituído por cultivares de feijoeiro (Pérola, BRSMG Majestoso, BRS Estilo, BRSMG Madrepérola, IPR Campos Gerais, IPR Tangará, IPR Andorinha, IPR 139, IAC Imperador, IAC Formoso, IAC Alvorada, IAC Milênio e Bola Cheia) e três tempos de armazenamento (grãos recém colhidos, com quatro e oito meses após a colheita), com quatro repetições. Foram avaliados a coloração do tegumento, teor de proteína bruta, tempo de cozimento, relação de hidratação e tempo para máxima hidratação. O período de armazenamento não altera significativamente os atributos qualitativos dos grãos, mantendo a maioria das características essenciais ao mercado consumidor. A BRSMG Madre pérola não apresentou alteração na cor do tegumento, e o menor tempo de cozimento foi apresentado pela cultivar IPR Andorinha. O escurecimento dos grãos de feijão não está associado com o aumento do tempo de cozimento. Todas as cultivares apresentam resultado satisfatório para o tempo de máxima hidratação e a relação de hidratação.
Potenciais genitores visando o melhoramento de batata para aparência de tubérculos e tolerância ao calor
Authors: Ribeiro Guilherme Henrique Martins Rodrigues , Pereira Pinto César Augusto Brasil
Published: April 2020

Em todo programa de melhoramento depois de definido os objetivos a etapa mais importante é a escolha dos genitores a serem utilizados. Assim este trabalho teve por objetivo a seleção de genitores que agregassem boa aparência dos tubérculos e tolerância ao calor a suas progênies. Utilizou-se neste trabalho famílias clonais obtidas de dialelo parcial entre cultivares com boa aparência de tubérculos e clones tolerantes ao calor. Foram avaliados caracteres de aparência, produtividade e peso específico dos tubérculos na primeira e segunda geração clonal, em condições de calor e temperaturas amenas respectivamente, por fim foi estimada a capacidade geral e especifica. Nos caracteres apontamento, profundidade de olhos, textura da periderme e peso específico dos tubérculos houve predomínio dos efeitos da capacidade geral de combinação em ambas as condições de ambiente. Formato e aparência geral dos tubérculos apresentaram predomínio de capacidade especifica de combinação. Constatou-se que alguns genótipos foram promissores em agregar boa aparência aos tubérculos como SR2 21-02, SR2 35-05, Monalisa e Vivaldi. Para tolerância ao calor e responsividade a melhoria do ambiente apenas o clone SR2 21-02 contribuiu favoravelmente para produtividade em ambos os ambientes. Concluiu-se que não existe genitor ideal para todas as características simultaneamente, entretanto o clone SR2 21-02 e a cultivar Vivaldi foram os mais promissores em produzir descendentes com boa aparência de tubérculos e com bom desempenho produtivo.
Витрати на охорону праці як об'єкт управлінського обліку і аналізу
Authors: Тацій І.В.
Published: April 2020

У статті досліджено динаміку  професійних захворювань і травматизму в Україні за останні роки. Обумовлена необхідність надання достовірних даних підприємствами різних форм власності для формування прозорої та об'єктивної інформації про витрати на охорону праці для вирішення проблем підвищення рівня професійної безпеки. Внесено зміни у класифікацію факторів щодо оцінки ефективності системи управління охороною праці. Запропоновано впровадження інтегрованої системи управління небезпеками і ризиками,  екологічними аспектами шляхом постійного вдосконалення діяльності підприємства в області охорони навколишнього середовища, здоров'я та безпеки на виробництві.
MODEL MANAJEMEN PEMASARAN BERSAMA BERBASIS INTERNET DALAM UPAYA MENINGKATKAN SISTEM PENJUALAN PRODUK MASYARAKAT DESA DI KABUPATEN SERANG
Authors: Deviyantoro Deviyantoro , Wahyudin  , Amarul
Published: April 2020

The research purpose was to produce a model of marketing management, the model is  joint marketing management of Internet-based for village product. The results of this research are expected to overcome the deadlock village product marketing that is less extensive and often trapped by realtor marketing system. This research method used is research and development approach.The results of comparative hypotheses on marketing management model shown significant differences product sales performance effectiveness of rural communities in the district Waringin Kurung and Keramatwatu before and after implementation of the model joint marketing management based onInternet or the  joint marketing management of Internet-based for village product is effective

 

Tujuan penelitian ini adalah menghasilkan suatu model manajemen pemasaran, hasil inovasi berupa cara pengelolaan pemasaran bersama produk unggulan desa berbasis internet. Hasil penelitian ini diharapkan dapat mengatasi kebuntuan pemasaran produk desa yang kurang luas dan sering terjebak oleh sistim makelar pemasaran. Metode penelitian ini menggunakan pendekatan penelitian dan pengembangan (research and development).Berdasarkan hasil pengamartan serta analisis data penelitian menunjukan bahwa pengujian hipotesis atas penerapan model yang dilakukan secara terbatas hanya pada 2 kecamatan menunjukkan terdapat perbedaan secara signifikan efektifitas kinerja penjualan produk masyarakat desa di kecamatan Waringin Kurung dan Kecamatan Keramatwatu  sebelum dan setelah penerapan model Pemasaran bersama berbasis Internet.
The Effect of Capital Structure on Profitability of Electricity Companies In Southeast Asia
Authors: Wibowo Agung , Rahim Rida
Published: April 2020

Capital structure is increasingly important in determining the optimal combination of funding for investment needs that can increase firm value from profitability. The study aims to examine the effect of capital structure on profitability of electricity companies in Southeast Asia. The study used multiple regression model represented by pooled least square to calculate 48-panel data from the annual financial report during the time period of 2009-2016. We utilized short-term debt to total assets (STD), long-term debt to total assets (LTD), total debt to total assets (TD), and debt to equity ratio (DER) as proxies of capital structure (independent variables). Operating income margin (OIM), return on asset (ROA), and return on equity (ROE) were the profitability proxies (dependent variables). Firm size and firm age were used as control variables in the study. The results of this study indicate that STD and LTD have a negative relationship that consequently has significant effect on LTD and OIM. Other than positive and negative relationships between the capital structure (TD and DER) and profitability, this study also finds that TD and DER have positive significant influence on OIM and ROE, but have negative insignificant relation with ROA. Thus, it is necessary to optimize the capital structure by adjusting the target of capital structure that can provide a balance on the marginal cost and marginal benefit.
The Implementation of Good University Governance in State Universities
Authors: Rulyanti Susi Wardhani  , Taufik Taufik  , Luk luk Fuadah  , Saadah Siddik
Published: April 2020

This study aims to determine the differences in the implementation of good university governance at state universities in South Sumatra and Bangka Belitung. The state universities were Bangka Belitung University, Sriwijaya University, Sriwijaya State Polytechnic, and Bangka Belitung Manufacturing Polytechnic. The principles of good university governance in this study include governance structure, autonomy, accountability, leadership, and transparency. The respondents of the study were structural officials. Research data were collected using a questionnaire. The analysis used Friedman different test because the groups comprised new and long-established state universities. The results of the analysis indicate that accountability and transparency in the implementation of good university governance in Bangka Belitung University are different from those in Sriwijaya University. Meanwhile, the implementation of good university governance in Sriwijaya Polytechnic is similar to that in Bangka Belitung Manufacturing Polytechnic.
The Capacity of the Road Network: Data Collection and Statistical Analysis of Traffic Characteristics
Authors: Shepelev Vladimir , Aliukov Sergei , Nikolskaya Kseniya , Shabiev Salavat
Published: April 2020

The possibilities of collecting the necessary information using multi-touch cameras and ways to improve road traffic data collection are considered. An increase in the number of vehicles leads to traffic jams, which in turn leads to an increase in travel time, additional fuel consumption and other negative consequences. To solve this problem, it is necessary to have a reliable information collection system and apply modern effective methods of processing the collected information. The technology considered in the article allows taking into account pedestrians crossing the intersection. The purpose of this article is to determine the most important traffic characteristics that affect the traffic capacity of the intersection, in other words, the actual number of passing cars. Throughput is taken as a dependent variable. Based on the results of the regression analysis, a model was developed to predict the intersection throughput taking into account the most important traffic characteristics. Besides, this model is based on the fuzzy logic method and using the Fuzzy TECH 5.81d Professional Edition computer program.
Multi-Step Short-Term Wind Speed Prediction Using a Residual Dilated Causal Convolutional Network with Nonlinear Attention
Authors: Shivam Kumar , Tzou Jong-Chyuan , Wu Shang-Chen
Published: April 2020

Wind energy is the most used renewable energy worldwide second only to hydropower. However, the stochastic nature of wind speed makes it harder for wind farms to manage the future power production and maintenance schedules efficiently. Many wind speed prediction models exist that focus on advance neural networks and/or preprocessing techniques to improve the accuracy. Since most of these models require a large amount of historic wind data and are validated using the data split method, the application to real-world scenarios cannot be determined. In this paper, we present a multi-step univariate prediction model for wind speed data inspired by the residual U-net architecture of the convolutional neural network (CNN). We propose a residual dilated causal convolutional neural network (Res-DCCNN) with nonlinear attention for multi-step-ahead wind speed forecasting. Our model can outperform long-term short-term memory networks (LSTM), gated recurrent units (GRU), and Res-DCCNN using sliding window validation techniques for 50-step-ahead wind speed prediction. We tested the performance of the proposed model on six real-world wind speed datasets with different probability distributions to confirm its effectiveness, and using several error metrics, we demonstrated that our proposed model was robust, precise, and applicable to real-world cases.
The Effect of Deep Energy Retrofit on The Hourly Power Demand of Finnish Detached Houses
Authors: Hirvonen Janne , Jokisalo Juha , Kosonen Risto
Published: April 2020

This study examines how the energy renovation of old detached houses affects the hourly power consumption of heating and electricity in Finland. As electrification of heating through heat pumps becomes more common, the effects on the grid need to be quantified. Increased fluctuation and peak power demand could increase the need for fossil-based peaking power plants or call for new investments to the distribution infrastructure. The novelty in this study is the focus on hourly power demand instead of just annual energy consumption. Identifying the influence of building energy retrofits on the instantaneous power demand can help guide policy and investments into building retrofits and related technology. The work was done through dynamic building simulation and utilized building configurations obtained through multi-objective optimization. Deep energy retrofits decreased both the total and peak heating power consumption. However, the use of air-source heat pumps increased the peak power demand of electricity in district heated and wood heated buildings by as much as 100%. On the other hand, peak power demand in buildings with direct electric heating was reduced by 30 to 40%. On the building stock level, the demand reduction in buildings with direct electric heating could compensate for the increase in the share of buildings with ground-source heat pumps, so that the national peak electricity demand would not increase. This prevents the increase of demand for high emission peaking power plants as heat pump penetration rises. However, a use is needed for the excess solar electricity generated by the optimally retrofitted buildings, because much of the solar electricity cannot be utilized in the single-family houses during summer.
Ukraine Energy Sector Management Using Hybrid Renewable Energy Systems
Authors: Sabishchenko Oleksandr , Rębilas Rafał , Sczygiol Norbert , Urbański Mariusz
Published: April 2020

The Ukrainian energy sector is one of the most inflexible energy sectors in the world as a result of the almost complete depreciation of the equipment of the main sources of power supply: nuclear, thermal, and hydropower. In connection with existing problems, there is a need to develop and use new energy-saving technologies based on renewable energy sources. In this proposed research, a regression model of renewable energy growth in the energy sector of Ukraine was developed. The studied literature reveals that the independent use of individual functioning elements of renewable energy sources function as the primary power source that is not an optimal solution for stable energy supply. This study proposes the use of hybrid renewable energy systems, namely a combination of two or more renewable energy sources that will help each other to achieve higher energy efficiency, accelerate the growth of renewable energy in the share of the Ukrainian energy sector and/or improve functioning with battery energy storages. Moreover, the use of hybrid renewable energy systems in Ukraine will reduce the human impact on the environment, realize the potential of local renewable energy resources and also increase the share of electricity generation from renewable energy sources. Therefore, mechanisms for managing state regulation of stimulating the development of hybrid renewable energy systems have been developed.