bluuebunny/crossref_metadata_2025 huggingface dataset:
Suplementação nutracêutica e fitoterápica no tratamento da fibromialgia: revisão de literatura
Authors: Santos Jefferson Jovelino Amaral dos , Tardivo Ana Paula , Salazar Thaís Cristina Coelho de Ornelas , Santos Victor Nascimento dos
Published: November 2021

A Fibromialgia (FB) é uma doença multifatorial que atinge uma grande parcela da população e ainda tem o seu diagnóstico como motivo de controvérsia. É caracterizada pela dor crônica em múltiplos pontos do corpo. O presente artigo teve como objetivo identificar ativos nutracêuticos que pudessem contribuir ao tratamento da FB nos seus múltiplos aspectos e assim, melhorar a qualidade de vida de seus portadores. O levantamento bibliográfico delimitou-se na busca de artigos em português e inglês nas bases de dados PubMed, SciELO e LILAC, publicados no período de janeiro de 2015 a março de 2020. Os princípios ativos mais encontrados no tratamento da FB foram a coenzima Q10, 25-hidroxivitamina D, probióticos (Lactobacillus Rhamnosus, Casei, Acidophilus e Bifidobacterium Bifidus) e fitoterápicos como gengibre, acerola, Spiraea Ulmari, passiflora, Elymus repens, em associação com outros produtos, o Crocus Sativus (açafrão) além do Ganoderma lucidum que é um tipo de cogumelo. É de fundamental importância a compreensão de como os suplementos podem auxiliar no tratamento da FB promovendo uma terapêutica mais natural, menos dispendiosa e com menos efeitos colaterais para os seus portadores.
Impacto de ácidos graxos essenciais na terapêutica suplementar da dismenorreia primária: uma revisão de ensaios clínicos
Authors: Guimarães Maiara Moeme Alvim , Araújo Edilene Maria Queiroz , Santos Junior Aníbal de Freitas , Travassos Ana Gabriela Álvares
Published: November 2021

Dismenorreia primária (DP) é a denominada cólica menstrual e o aparecimento de sintomas pode estar associado à ação das prostaglandinas (PG) e leucotrienos (LT). Os ácidos graxos essenciais (AGE), principalmente o ômega 3, possuem propriedades anti-inflamatórias inibitórias da síntese de PG.  Assim, esta revisão sistemática tem como objetivo discutir o uso da suplementação de AGE no tratamento de DP. Estudos originais do tipo ensaio clínico, publicados entre 2000 a 2021 foram pesquisados nos bancos de dados Pubmed e Scielo. Oito artigos foram incluídos e analisados neste estudo. A partir dos resultados afirma-se que os AGE, sobretudo ômega 3, são relevantes no tratamento da DP, identificando-se como mecanismo de ação a inibição da atividade da ciclo-oxigenase pelo ômega-3, que leva a menor produção de PG e LT pró-inflamatórias, aumentando a formação de seus derivados, anti-inflamatórios. Logo, sugere-se que a suplementação dietética a partir de 300 mg de ômega-3, 8-2 dias antes e até 3-2 dias após a menstruação, principalmente após 2 meses, reduz dor em mulheres com DP.
Crescimento e produção de feijão-caupi BRS Tumucumaque cultivada em diferentes densidades populacionais
Authors: Ottoni Guilherme , Oliveira Júnior Manoel Xavier de , Bezerra Neto Francisco Valdevino , Amaral Alisson Macendo , Santos Maria Ângela Cruz Macêdo dos
Published: November 2021

O feijão-caupi é uma excelente fonte proteica de origem vegetal com elevado valor nutricional, muito importante nas regiões Norte, Nordeste e Centro-Oeste do Brasil. A densidade de semeadura pode influenciar os caracteres agromorfológicos das culturas, principalmente a produtividade de grãos. Objetivou-se com este trabalho, avaliar a influência de diferentes densidades populacionais no crescimento e na produção de grãos da cultivar BRSTumucumaque. O experimento foi conduzido no município de Chapada Gaúcha - MG entre fevereiro e maio de 2019. O delineamento experimental foi o de blocos casualizados, com 4 repetições, composto por cinco densidades populacionais (100.000, 150.000, 200.000, 250.000 e 300.000 plantas ha-1) em espaçamento de 0,5 m. O crescimento foi avaliado pela altura de planta (AP) diâmetro de caule (DC) e número de vagens por planta (NVP). Os caracteres de produção avaliados foram número de grãos por vagens (NGV), massa de 100 grãos (M100G) e produtividade (PROD). Apenas a produtividade foi influenciada de forma linear e positiva pela variação da densidade populacional. O aumento da população de 100.000 para 300.000 plantas ha-1 resultou em um incremento total de 33,5% na produtividade de grãos, equivalente a 1.523,46 Kg ha-1.
Especialização e especialidade em Fisioterapia: estratégias de qualificação profissional
Authors: Silva Geraedson Aristides da , Teixeira Geraldo Magella , Junior Romildo Silva Dantas , Urubá Carlos Victor Tenório , Costa Lais da Silva , Pereira Jefferson Eduardo da Silva
Published: November 2021

A Fisioterapia é a profissão que dentre tantas competências e habilidades, objetiva desenvolver, manter e restaurar o movimento e a capacidade funcional ao longo da vida. A especialização nesta profissão tem grande contribuição e potencializa a capacidade técnica e na tomada de decisões de forma assertivas no que corresponde à promoção, recuperação e prevenção da saúde. Frente a isto, este estudo objetivou descrever sobre as especializações e especialidades na Fisioterapia como estratégias de formação e qualificação profissional. Trata-se de uma revisão bibliográfica descritiva tendo como fonte as seguintes bases de dados: SciELO, COFFITO, CREFITOS e Descritores em Ciências da Saúde. Observou-se a importância e contribuição dos processos de especializações e especialidades para a formação e qualificação profissional do fisioterapeuta desde o momento de refletir qual especialidade durante a graduação até a aplicação dos conhecimentos e práxis no dia a dia de trabalho assistencial ou docente adquiridos nas especializações. Observou-se também, quais estratégias e ferramentas são utilizadas para a formação e o aprimoramento para o profissional da Fisioterapia. Estima-se que os fisioterapeutas busquem mais qualificação seja através das especializações Latu Sensu, Stricto Sensu e/ou Especialidade Profissional por prova de qualificação, para que o mesmo possa atuar de forma mais precisa no processo saúde-doença da população e aperfeiçoe sua práxis.
Síndrome de Netherton: diagnóstico, formas de tratamento e o papel do cuidado farmacêutico em prol da saúde nesta patologia
Authors: Meyer Sabrina Ferreira , Trevisan Márcio
Published: November 2021

A Síndrome de Netherton (SN) é uma dermatose bastante rara e grave, tem como características pele avermelhada com abundante descamação, gerando regeneração rápida da pele e provocando perda de líquidos. O diagnóstico é desafiador, geralmente pode ser confundida com outras comorbidades. A SN não possui cura, apenas tratamento. O cuidado farmacêutico deste agravo ajuda na melhoria da qualidade de vida do paciente, como também melhor adaptação ao tratamento. Este trabalho tem como objetivo levantar com base na literatura atual as características da SN, facilitar o diagnóstico; demostrar suas diversas formas de tratamento; analisar o papel do farmacêutico para melhorar a qualidade de vida do portador. Para essa investigação adotou-se uma pesquisa bibliográfica, fundamentada em revisão de literatura de artigos científicos disponibilizados no banco de dados eletrônico da Scientic Eletronic Library Online (SciELO) e Medical Literature Analysis And Retrieval System Online (MEDLINE). Nas bibliografias revisadas foi possível levantar que a SN é causada por mutação genética, possui diagnóstico complexo, podendo ser confundida ictiose bolhosa, dermatite atópica, entre outros. Alguns dos tratamentos é utilizado emolientes, diminuindo a perda transepidérmica de água, também se utiliza o dupilumabe, medicação biológica de anticorpo monoclonal humano IgG4, melhorando a condição da pele, bem como o cuidado farmacêutico neste cenário traz grandes melhorias na adesão ao tratamento. Percebe-se que ainda há muito estudo para ser realizado e conseguir melhorar ainda mais o bem-estar desses indivíduos, assim como mais pesquisas sobre a síndrome para ser possível um diagnóstico rápido e tratamentos eficazes.
Saúde e qualidade de vida dos agentes de nível médio do trabalho de enfermagem a partir da terceira idade
Authors: Sousa João Pedro Neto de , Ribeiro Antônio César , Bortolini Juliano
Published: November 2021

A investigação da qualidade de vida relacionado a saúde profissional é relevante podendo esta refletir na saúde do profissional de enfermagem e assim impactar em sua qualidade de vida relacionada à saúde. Objetivo: analisar o perfil de saúde e a qualidade de vida relacionada à saúde dos agentes de nível médio da enfermagem a partir da terceira idade. Método: Estudo transversal de abordagem quantitativa, com os agentes de nível médio da enfermagem na terceira idade, com aplicação de roteiro norteador além do instrumento The Medical Outcomes Study 36-item Short-Form Health Survey (SF-36), durante o segundo semestre de 2019. Os dados coletados foram organizados e tabulados por meio da frequência absoluta (n) e relativa (%) e apresentados em tabelas, além da realização do teste Shapiro-Wilk para verificar a normalidade dos dados e após procedeu-se com teste não paramétrico para medianas de Kruskal-Wallis, que quando significativo (p<0,05), realizou-se o teste de Conover-Iman para a comparação múltipla entre as medianas. Resultados: fatores como obesidade, sedentarismo, limitações físicas, doenças crônicas e ocupacionais, sobrecarga e desgastes oriundos do trabalho, foram identificados como agravantes à saúde e qualidade de vida dos profissionais. Com aplicação do instrumento SF-36 observou-se que o domínio aspectos sociais apresentou melhor escore médio, enquanto o domínio de estado geral da saúde refletiu um escore de menor média. Conclusão: Ademais, conclui-se que a enfermagem ainda carece de melhores condições em suas atividades laborais e de novas estratégias para o enfrentamento do adoecimento na enfermagem.
Discriminação racial de jovens negros no Brasil: revisão integrativa
Authors: Oliveira Eliany Nazaré , França Sabrina Silva , Silva Emília Nascimento , Rodrigues Caio San , Ziesemer Ravena Petra Mororó , Feijó Ivan Gabriel Sousa , Ximenes Neto Francisco Rosemiro Guimarães , Vasconcelos Maristela Inês Osawa , Aragão Joyce Mazza Nunes , Costa Maria Suely Alves , Lima Gleisson Ferreira , Furtado Juliana Solon
Published: November 2021

O objetivo do presente estudo foi investigar o que apontam as evidências científicas sobre a discriminação racial de jovens negros no Brasil. O método realizado foi uma revisão integrativa da literatura científica, a partir da questão norteadora: o que apontam as evidências científicas sobre a discriminação racial de jovens negros no Brasil? A busca foi realizada em seis bases de dados, sendo adotados como critérios de inclusão artigos originais, sem restrição de período, nos idiomas português, inglês ou espanhol, realizados no Brasil e com texto completo disponível. Excluíram-se os estudos incompletos e duplicados. Foram selecionados dez estudos, publicados entre 2003 e 2021, sendo oito artigos científicos e duas dissertações. Seis desses estudos foram publicados em língua portuguesa e quatro em língua inglesa. Evidenciou-se que os estudos analisam as consequências da discriminação racial em três grandes eixos: educação, violência e mercado de trabalho. Conclui-se que os estudos selecionados apontam evidências de que a discriminação racial no Brasil, ainda, é algo recorrente. O quantitativo reduzido de obras, torna-se preocupante, já que o conhecimento científico é de suma importância para compreensão desse fenômeno. Portanto, urge elaboração de mais estudos que abordem o fenômeno da discriminação racial de jovens negros no Brasil.
Vulnerabilidades e ações desenvolvidas na população indígena de Tocantínia - TO acometida por COVID-19: Percepção dos profissionais da saúde
Authors: Sousa Samara Silva de , Silva Andressa Layse Calixto , Brito Andressa de Sousa , Noleto Alícia Leocádio , Santos Pollyanna de Ulhôa
Published: November 2021

Objetivo: Analisar a percepção dos profissionais de saúde sobre as vulnerabilidades dos povos indígenas diante do COVID-19, bem como identificar estratégias que são usadas para minimizá-las. Metodologia: Estudo do tipo qualitativo, descritivo, elaborado após a análise de questionários para avaliação do conhecimento e comportamento referido desses povos na visão dos profissionais que atuam diretamente e efetivamente nessa assistência. Os dados apresentados foram executados pelo software IRAMUTEQ com análises estatísticas sobre os corpus textuais e palavras. Foi aplicada a Classificação Hierárquica Descendente, em que as palavras foram aglomeradas em classes e os dados interpretados para a discussão subsequente. Resultados: Foram apresentadas três categorias: Estrutura física e Equipamentos de Proteção Individual (EPI’s) para o atendimento de saúde aos indígenas; Ações de promoção de Saúde e prevenção de agravos referentes à COVID- 19 nas aldeias e a percepção dos indígenas sobre o coronavírus na visão dos profissionais. As categorias foram elaboradas de acordo com a frequência das palavras citadas nas entrevistas aos profissionais, conforme a Classificação Hierárquica Descendente (CHD). Considerações finais: Notou-se o empenho dos profissionais de saúde na assessoria dos povos indígenas, assim como na propagação de informações e medidas de prevenção ao coronavírus. Apesar das dificuldades enfrentadas, como a resistência e os hábitos culturais, houveram grandes mudanças que contribuíram nas estratégias de promoção à saúde e prevenção de doenças.
Evaluation of the integrated model of the rational drug use into the Bachelor of Nursing Science program in Thailand: A mixed-methods study
Authors: Turner Kamolrat , Suwannapong Kanoklekha , Putthikhan Phawida , Charoensuk Sukjai , Radabutr Matanee , Angsirisak Naruemol , Thadakant Streerut , Vaisurasingha Laddawon , Theinpichet Suntharawadee
Published: November 2021

Background: Integration of rational drug use (RDU) into a nursing program to increase nurse graduates’ RDU competencies is essential to solving the problem of irrational drug use.
Objective: This study aimed to evaluate the integrated model of the RDU into the Bachelor of Nursing Science (BNS) program developed by the Thailand Nursing and Midwifery Council (TNMC).
Methods: A mixed-methods study was designed using a sequential explanatory design. The whole population of 3,848 nurse educators and 9,249 nurse graduates from 86 nursing education institutions across Thailand in Academic Year 2018 were recruited for quantitative data collection. Fifty nurse educators selected as representatives of the nursing education institutions were recruited for qualitative data collection. Online questionnaires were sent to collect information regarding the context, input, process, and product relating to the model, while structured focus group guidelines were developed to obtain more details in assessing the model. The data were analyzed using descriptive statistics and content analysis.
Results: The findings showed that the context and policy of utilizing the model to increase nurse graduates’ RDU competencies were well accepted. The nurse educators’ RDU competencies, the input of the model, were rated at a high level. The process of the model was implemented as guided at almost all nursing education institutions. The product of the model, the RDU competencies of the nurse graduates, was reported at a high level.
Conclusion: The model of integrating the RDU into the BNS program developed by the TNMC was well performed and resulted in high RDU competencies of the nurse graduates. This integration model should be published and applied in nursing schools worldwide to enhance RDU competencies of nurse graduates.
Питання зовнішнього контролю якості лабораторних досліджень на сифіліс у лікувальних закладах України
Authors:   SE «Institute of Dermatology and Venereology of NAMS of Ukraine», Kutova V. V. , Kutasevych Ya. F. ,   SE «Institute of Dermatology and Venereology of NAMS of Ukraine», Belokon O. N. ,   SE «Institute of Dermatology and Venereology of NAMS of Ukraine», Degtyar T. V. ,   SE «Institute of Dermatology and Venereology of NAMS of Ukraine», Nikitenko I. N. ,   SE «Institute of Dermatology and Venereology of NAMS of Ukraine», Shcherbakova Yu. V. ,   SE «Institute of Dermatology and Venereology of NAMS of Ukraine»
Published: November 2021

The objective of the work is to identify systemic and random errors in the formulation of controlled methods and to achieve comparative results obtained by laboratories participating in external quality control of laboratory tests for syphilis. Materials and methods. Laboratories of three levels took part in the activities of external quality control of serological diagnostics of syphilis: clinical diagnostic laboratories (CDL) of medical institutions of scientific research institutes of the NAMS of Ukraine, serological departments as part of the CDL of the dermatovenerological profile of the RDVD, CDVD. Results. The quality of serological tests for syphilis in 21 CDL (serological departments) was assessed using the following methods: RMP, RPR, Rapid-test, TPHA, FTA-abs, ELISA in three control serum samples according to formal and essential characteristics. The most significant differences in the results were revealed in the study of control serum samples with a low content of antibodies and those without antibodies to the causative agent of syphilis in the non-treponemal RMP test and the treponemal FTA-abs test. Conclusions. The conducted studies have shown the high efficiency of the practical application of the developed system of external quality control of laboratory methods for diagnosing syphilis.
BIM-моделирование как технология повышения конкурентноспособности строительной отрасли
Authors: Байорис Александра Ромасовна , Малиновский Максим Александрович , Ершов Анатолий Викторович
Published: November 2021

В статье описывается применение BIM в качестве повышения конкурентоспособности в строительной отрасли. Реализация BIM осуществляется путем программно-аппаратного обеспечения, позволяющего организовывать совместную работу всех заинтересованных лиц.
Pengabaian Penerapan Sanksi oleh Pejabat Berwenang Terhadap Pelanggaran Disiplin Berat Pegawai Negeri Sipil
Authors: Rasyid Fahrudin , Sensu La , Jafar Kamaruddin
Published: November 2021

Penelitian ini mengkaji tentang pengabaian penerapan sanksi oleh pejabat berwenang bagi pegawai negeri sipil yang melanggar peraturan disiplin kepegawaian dapat dinilai sebagai pelanggaran hukum, serta mengetahui sanksi hukum bagi pejabat berwenang yang mengabaikan penerapan sanksi terhadap pelanggaran disiplin berat Pegawai Negeri Sipil.Penelitian ini adalah penelitian Hukum Normatif atau doktrinal dalam sifat penelitian preskriptif. Pendekatan yang digunakan adalah pendekatan Undang-Undang dan pendekatan historis dengan bahan hukum yang digunakan berupa data sekunder yang terdiri dari bahan hukumprimer, sekunder dannonhukum.Teknik pengumpulan bahan hukum dilakukan dengan penelitian kepustakaan dan dianalisis menggunakan logika deduktif.Berdasarkan penelitian ini diperoleh hasil bahwa Pengabaian penerapan sanksi oleh pejabat berwenang terhadap pelanggaran disiplin berat Pegawai Negeri Sipil dapat dikualifikasi perbuatan pelanggaran hukum. Karena telah menyalahi ketentuan hukum pada pasal 21 ayat (1), (2), (3), dan (4) Peraturan Pemerintah Nomor 53 tahun 2010 serta tidak menjalankan norma hukum dalam Pasal 87 ayat (4) huruf b Undang-undang5 tahun 2014 dan Pasal 250 huruf b Peraturan Pemerintah Nomor 11 tahun 2017. Sanksi pejabat yang mengabaikan penerapan sanksi terhadap pelanggaran Disiplin berat Pegawai Negeri Sipil, pejabat tersebut dijatuhi hukuman disiplin atasannya yang sama dengan jenis hukuman disiplin yang seharusnya dijatuhkan kepada PNS yang melakukan pelanggaran disiplin dan apabila penjatuhan sanksi disiplin berat PNS menjadi kewenangan kepala daerah selaku pejabat pembina kepegawaian tidak melaksanakan penjatuhan sanksi disiplin dapat dikualifikasi perbuatan pelanggaran hukum serta diberikan sanksi hukum yaitu diberhentikan dari jabatannya.
Kedudukan Hukum Peraturan Desa dalam Sistem Peraturan Perundang-Undangan
Authors: Agustin Agustin , Sinapoy Muh. Sabaruddin , Jafar Kamaruddin
Published: November 2021

Peraturan Desa adalah peraturan perundang-undangan yang ditetapkan oleh Kepala Desa setelah dibahas dan disepakati bersama Badan Permusyawaratan Desa. Setelah Undang-Undang Nomor 12 Tahun 2011 Tentang Pembentukan Peraturan Perundang-Undangan berlaku, menghapus peraturan desa dalam jenis dan hierarki peraturan perundang-undangan. Peraturan Desa yang berbentuk rancangan Peraturan Desa, mendapatkan evaluasi dari Bupati/Walikota sebelum ditetapkan menjadi Peraturan Desa. Terkait dengan pembentukan Peraturan Desa, pembinaan dan pengawasan dilakukan oleh Pemerintah Kabupaten/Kota sebagaimana dimaksud yakni melakukan evaluasi dan pengawasan Peraturan Desa. Pengawasan dalam hal ini adalah termasuk pembatalan peraturan desa.
Keberlakuan Produk Hukum Daerah Tanpa Prosedur Fasilitasi dalam Pembentukan Peraturan Daerah
Authors: Hasan Muhammad , Sensu La , Jafar Kamaruddin
Published: November 2021

Penelitian ini difokuskan pada keberlakuan produk hukum daerah tanpa prosedur fasilitasi dalam pembentukan peraturan daerah. keberlakuan produk hukum daerah berkaitan dengan pembentukan Peraturan Daerah di Kabupaten/Kota tanpa prosedur fasilitasi ke Gubernur dalam pembentukan Peraturan Daerah. Oleh karena itu, penelitian ini memfokuskan pada masalah sebagai berikut: 1. Apakah rancangan peraturan daerah (ranperda) tanpa prosedur fasilitasi dalam pembentukan produk hukum daerah dapat diberlakukan? 2. Bagaimana kedudukan hukum fungsi fasilitasi dalam pembentukan produk hukum peraturan daerah kabupaten/kota? Penelitian ini adalah penelitian hukum normatif, yaitu melihat keberlakuan dengan menjawab, menganalisis keberlakuan produk hukum daerah terhadap fasilitasi dalam pembentukan peraturan daerah. Penelitian yang berbasis pada inventarisasi hukum positif, penelitian terhadap asas-asas hukum, dan penelitian hukum inconcreto. Pendekatan yang digunakan adalah pendekatan secara yuridis normatif. Pendekatan secara yuridis normatif adalah pendekatan yang dilakukan dengan cara mempelajari perundang-undangan, teori-teori dan konsep-konsep yang berhubungan dengan permasalahan yang akan diteliti. Penelitian ini menggunakan bahan hukum primer, yaitu bahan hukum yang erat kaitannya dengan permasalahan yang akan diteliti yang meliputi peraturan perundang-undangan dan bahan hukum sekunder yang memberikan penjelasan mengenai bahan hukum primer, meliputi dokumen, buku, makalah, laporan penelitian, serta bahan hukum lainnya yang relevan dengan materi penelitian ini.Berdasarkan penelitian yang dilakukan, hasil penelitian menunjukkan bahwa rancangan Perda tanpa prosedur fasilitasi dalam pembentukan produk hukum daerah tidak sesuai dengan ketentuan peraturan perundang-undangan dalam hal ini UU No. 23 Tahun 2014, karena prosedur fasilitasi merupakan bagian dari prosedur dalam pembentukan rancangan Perda sebagaimana dimaksud dalam UU No. 23 Tahun 2014. Sehingga dalam pembentukan rancangan Perda harus melewati prosedur fasilitasi sebagai pedoman dalam pemberian nomor register rancangan Perda sebelum ditetapkan oleh Kepala Daerah dan diundangkan oleh Sekretaris Daerah dan dampak/akibat hukum tanpa prosedur fasilitasi dalam pembentukan Perda adalah batal demi hukum karena melanggar prosedur pemberian nomor register rancangan Perda sebagaimana diatur dalam UU No. 23 Tahun 2014 yang mencakup pula prosedur fasilitasi yang diatur dalam Permendagri No. 80 Tahun 2015 sebagai pedoman dalam pemberian nomor register rancangan Perda.
Analisis Hukum Penggunaan Spektrum Frekuensi Radio Tanpa Izin Berdasarkan Undang-Undang Nomor 36 Tahun 1999 Tentang Telekomunikasi
Authors: Ali Umar , Tatawu Guasman , Sinapoy Muhammad Sabaruddin
Published: November 2021

Aspek perizinan spektrum frekuensi Radio sesuai dengan Undang-Undang nomor 36 Tahun 1999 Tentang Telekomunikasi merupakan konsep perizinan yang mengedepankan prosedur administrasi dan mendorong pembinaan dan pertumbuhan telekomunikasi yang sehat, lebih efisien dan dapat meningkatkan pendapatan Negara Bukan Pajak. Pelaksanaan pengawasan terhadap penggunaan spektrum frekuensi radio terletak pada aspek administrasi dan ekonomi, ini terbukti dengan adanya unsur perizinan, dan biaya Hak Penggunaan (BHP) frekuensi. Pasal 11 Undang-Undang Nomor 36 Tahun 1999 secara jelas menyatakan bahwa izin dikeluarkan oleh Menteri, dilakukan dengan prinsip sederhana, transparan dan tepat waktu. Dari aspek pengendalian sendiri selain sanksi administrasi berupa pencabutan izin, pelanggar juga dapat dikenakan pidana jika penyelenggaraan telekomunikasi belum mendapat izin dari Menteri. Maka terhadap penyelenggara telekomunikasi baik itu instansi pemerintah, swasta, maupun perusahaan penyedia jasa layanan telekomunikasi secara tegas dan diwajibkan memiliki izin penggunaan spektrum frekuensi radio.
Kebijakan Hukum Pidana terhadap Kedaruratan di Situasi Pandemi COVID-19 Sebagai Alasan Pembebasan Bersyarat
Authors: Jaya Muhar , Herman Herman , Handrawan Handrawan
Published: November 2021

Tulisan ini ditujukan pada analisis penerapan kebijakan pembebasan narapidana di tengah pandemi COVID-19 melalui Peraturan Menteri Hukum dan Hak Asasi Manusia Nomor 10 Tahun 2020 tentang Syarat Pemberian Asimilasi dan Hak Integrasi Bagi Narapidana dan Anak. Selain itu, artikel ini menguji Pencegahan dan Penanggulangan Penyebaran COVID-19, serta Keputusan Menteri Hukum dan HAM No. M.HH-19.PK.01.04.04/2020 tentang Pengeluaran dan Pembebasan Narapidana dan Anak Melalui Asimilasi dan Integrasi dalam Rangka Pencegahan dan Penanggulangan Penyebaran COVID-19. Penelitian ini menggunakan penelitian hukum melalui pendekatan peraturan undang-undangan dan konsep. Penelitian ini menghasilkan kebijakan guna mencegah penularan dan penyebaran COVID-19 bukan solusi yang tepat dan hanya bersifat sementara. Dalam konsepsi Pendekatan-Kebijakan seharusnya kebijakan pembebasan bersyarat disituasi pandemi COVID-19 ini berupaya untuk mengatasi COVID-19 sebagai masalah-masalah sosial dan masalah kemanusian serta merupakan bagian dari upaya memberikan perlindungan kepada masyarakat. Sehingga pembebasan narapidana jangan hanya difokuskan untuk sekedar mencegah COVID-19 dan over kapasitas penjara, namun tetap harus memperhatikan aspek keadilan dan efek jera sebagai tujuan pemidanaan yaitu untuk memperbaiki pelaku agar menjadi baik dan tidak mengulangi kejahatannya kembali.
Biomechanics of Lumbar Spine Injury in Road Barrier Collision–Finite Element Study
Authors: Pachocki L. , Daszkiewicz K. , Łuczkiewicz P. , Witkowski W.
Published: November 2021

Literature and field data from CIREN database have shown that lumbar spine injuries occur during car crashes. There are multiple hypotheses regarding how they occur; however, there is no biomechanical explanation for these injuries during collisions with road safety barriers (RSBs). Therefore, the objective of this study was to investigate the mechanics of vertebral fractures during car collisions with concrete RSBs. The finite element method was used for the numerical simulations. The global model of the car collision with the concrete RSB was created. The lumbar spine kinematics were extracted from the global simulation and then applied as boundary conditions to the detailed lumbar spine model. The results showed that during the collision, the occupant was elevated, and then dropped during the vehicle landing. This resulted in axial compression forces 2.6 kN with flexion bending moments 34.7 and 37.8 Nm in the L2 and L3 vertebrae. It was shown that the bending moment is the result of the longitudinal force on the eccentricity. The lumbar spine index for the L1–L5 section was 2.80, thus indicating a lumbar spine fracture. The minimum principal strain criterion of 7.4% and damage variable indicated L2 and L3 vertebrae and the inferior part of L1, as those potentially prone to fracture. This study found that lumbar spine fractures could occur as a consequence of vehicle landing during a collision with a concrete RSB mostly affecting the L1–L3 lumbar spine section. The fracture was caused by a combination of axial forces and flexion bending moments.
Dephosphorylation of Caveolin-1 Controls C-X-C Motif Chemokine Ligand 10 Secretion in Mesenchymal Stem Cells to Regulate the Process of Wound Healing
Authors: Wang Panpan , Zhao Yingji , Wang Juan , Wu Zhiying , Sui Bingdong , Mao Xueli , Shi Songtao , Kou Xiaoxing
Published: November 2021

Mesenchymal stem cells (MSCs) secrete cytokines in a paracrine or autocrine manner to regulate immune response and tissue regeneration. Our previous research revealed that MSCs use the complex of Fas/Fas-associated phosphatase-1 (Fap-1)/caveolin-1 (Cav-1) mediated exocytotic process to regulate cytokine and small extracellular vesicles (EVs) secretion, which contributes to accelerated wound healing. However, the detailed underlying mechanism of cytokine secretion controlled by Cav-1 remains to be explored. We show that Gingiva-derived MSCs (GMSCs) could secrete more C-X-C motif chemokine ligand 10 (CXCL10) but showed lower phospho-Cav-1 (p-Cav-1) expression than skin-derived MSCs (SMSCs). Moreover, dephosphorylation of Cav-1 by a Src kinase inhibitor PP2 significantly enhances CXCL10 secretion, while activating phosphorylation of Cav-1 by H2O2 restraints CXCL10 secretion in GMSCs. We also found that Fas and Fap-1 contribute to the dephosphorylation of Cav-1 to elevate CXCL10 secretion. Tumor necrosis factor-α serves as an activator to up-regulate Fas, Fap-1, and down-regulate p-Cav-1 expression to promote CXCL10 release. Furthermore, local applying p-Cav-1 inhibitor PP2 could accelerate wound healing, reduce the expression of α-smooth muscle actin and increase cleaved-caspase 3 expression. These results indicated that dephosphorylation of Cav-1 could inhibit fibrosis during wound healing. The present study establishes a previously unknown role of p-Cav-1 in controlling cytokine release of MSC and may present a potential therapeutic approach for promoting scarless wound healing.
Loss of Angiotensin II Type 2 Receptor Improves Blood Pressure in Elastin Insufficiency
Authors: Lin Michelle , Roth Robyn A. , Kozel Beth A. , Mecham Robert P. , Halabi Carmen M.
Published: November 2021

There is ample evidence supporting a role for angiotensin II type 2 receptor (AT2R) in counterbalancing the effects of angiotensin II (ang II) through the angiotensin II type 1 receptor by promoting vasodilation and having anti-inflammatory effects. Elastin insufficiency in both humans and mice results in large artery stiffness and systolic hypertension. Unexpectedly, mesenteric arteries from elastin insufficient (Eln+/−) mice were shown to have significant vasoconstriction to AT2R agonism in vitro suggesting that AT2R may have vasoconstrictor effects in elastin insufficiency. Given the potential promise for the use of AT2R agonists clinically, the goal of this study was to determine whether AT2R has vasoconstrictive effects in elastin insufficiency in vivo. To avoid off-target effects of agonists and antagonists, mice lacking AT2R (Agtr2−/Y) were bred to Eln+/− mice and cardiovascular parameters were assessed in wild-type (WT), Agtr2−/Y, Eln+/−, and Agtr2−/Y;Eln+/− littermates. As previously published, Agtr2−/Y mice were normotensive at baseline and had no large artery stiffness, while Eln+/− mice exhibited systolic hypertension and large artery stiffness. Loss of AT2R in Eln+/− mice did not affect large artery stiffness or arterial structure but resulted in significant reduction of both systolic and diastolic blood pressure. These data support a potential vasocontractile role for AT2R in elastin insufficiency. Careful consideration and investigation are necessary to determine the patient population that might benefit from the use of AT2R agonists.
Geodiversity Assessment as a First Step in Designating Areas of Geotourism Potential. Case Study: Western Carpathians
Authors: Chrobak Anna , Novotný Ján , Struś Paweł
Published: November 2021

Geodiversity is the natural diversity of features of geological structure, relief, and soil cover, including the relationships between these features, their properties, and their impact on other elements of the natural and cultural environment. It is described and analyzed using various types of quantitative, qualitative, or quantitative–qualitative methods. The concept of a geodiversity map presented in this article belongs to the third of these groups of methods. Despite the use of optimization methods in the form of a hexagon grid or the analytic hierarchy process calculator, it still remains partially subjective. The use of this method to calculate the geodiversity of an entire province (the Western Carpathians) gives a general view of the natural diversity of this area and allows regions to be selected for more detailed analyses or comparisons to be made between them. The geodiversity map is also a very good background on which to illustrate geotourist potential, which is expressed in terms of the number and distribution of geosites. However, in the case of the Western Carpathians, these two variables do not correlate with each other.
The Mode of Trench-Parallel Subduction of the Middle Ocean Ridge
Authors: Shen Xiaobing , Leng Wei
Published: November 2021

Trench-parallel subduction of mid-ocean ridges occurs frequently in plate motion history, such as along the western boundary of the Pacific plate in the early Cenozoic and along the eastern boundary of the Pacific plate at present. Such subduction may strongly alter the surface topography, volcanic activity and slab morphology in the mantle, whereas few studies have been conducted to investigate its evolutionary process. Here, we construct a 2-D viscoelastoplastic numerical model to study the modes and key parameters controlling trench-parallel subduction of mid-ocean ridges. Our model results show that the subduction modes of mid-ocean ridges can be primarily categorized into three types: the fast spreading mode, the slow spreading mode, and the extinction mode. The key factor controlling these subduction modes is the relative motion between the foregoing and the following oceanic plates, which are separated by the mid-ocean ridge. Different subduction modes exert different surface geological expressions, which may explain specific evolutionary processes related to mid-ocean ridge subduction, such as topographic deformation and the eruption gap of volcanic rocks in East Asia within 55–45 Ma and in the western North American plate during the late Cenozoic.
Radiotherapy Plus Chemotherapy Leads to Prolonged Survival in Patients With Anaplastic Thyroid Cancer Compared With Radiotherapy Alone Regardless of Surgical Resection and Distant Metastasis: A Retrospective Population Study
Authors: Zhou Weili , Yue Yangyang , Zhang Xin
Published: November 2021

Background

Whether anaplastic thyroid cancer (ATC) patients benefit more from radiotherapy plus chemotherapy (RCT) than from radiotherapy alone (RT) was controversial. We aimed to investigate the effectiveness of RCT versus RT on ATC overall and within subgroups by surgical resection and distant metastasis in a large real-world cohort.

Methods

Patients with ATC diagnosed between 2004 and 2015 were identified from the Surveillance, Epidemiology, and End Results Program database. Inverse probability weighting (IPW) was performed to balance variables between the two groups. Multivariate Cox proportional hazard model and Fine-Gray compete-risk model were carried out to investigate prognostic factors relating to overall survival (OS) and cancer-specific survival (CSS). Subgroup analysis was carried out, and a forest plot was graphed.

Results

Of the 491 ATC patients, 321 (65.4%) were in the RCT group and 170 (34.6%) were in the RT group. The median OS was 4 months [interquartile range (IQR) 2–7] and 2 months (IQR 1–4) for patients in the RCT and RT groups, respectively. As indicated by the inverse probability weighting multivariate regression, RCT was associated with significantly improved OS (adjusted HR = 0.69, 95% CI = 0.56–0.85, p < 0.001) and CSS (adjusted subdistribution HR = 0.77, 95% CI = 0.61–0.96, p = 0.018). The prominent effect of RCT versus RT alone remains significant within each subgroup stratified by surgical resection and distant metastasis. Older age, single marital status, surgical resection, distant metastasis, and tumor extension were significant prognostic factors of survival.

Conclusions

RCT contributes to prolonged OS and CSS compared with RT alone in ATC patients, regardless of surgical resection and distant metastasis. RCT should be preferentially applied to ATC patients.
The Role of the Global Value Chain in Improving Trade and the Sustainable Competitive Advantage: Evidence From China’s Manufacturing Industry
Authors: Deqiang Shi , Zhijun Chen , Hajduk-Stelmachowicz Marzena , Larik Abdul Razaque , Rafique Muhammad Zahid
Published: November 2021

In the domain of globalization, the global value chain (GVC) is formed across diverse economies. Owing to the expansion of economic globalization and the resultant global trade liberalization, the geographical isolation of production and consumption has resulted in the transfer of polluting emissions from advanced economies to developing states. Developing economies, falling in the middle and low end of the GVC, have to strive hard to expand their production in the GVC, while simultaneously addressing the consequent environmental damage and attending to the core environmental concerns of sustainable growth, energy preservation and drastic cuts in CO2. This paper addresses how manufacturing subsidiaries can improve their low-carbon innovation ability and help to achieve a sustainable competitive advantage through the embedded GVC. Data were gathered employing interview and survey methods, 31 manufacturing companies and 56 enterprise groups across 16 Chinese provinces were selected as the case study. A partial least square structural equation modelling was adopted to analyse the responses. The results indicate that the embedded GVC significantly enhances low-carbon innovation capability and promotes a sustainable competitive advantage. This study proposes that companies should continuously identify high-quality resources from the GVC and discover ways of integrating internal and external carbon innovation resources to form innovation capabilities.
Physiological Responses of Sargassum muticum, a Potential Golden Tide Species, to Different Levels of Light and Nitrogen
Authors: Yan Fang , Li Lingxue , Yu Daode , Cui Cuiju , Zang Shasha , Xu Zhiguang , Wu Hongyan
Published: November 2021

Sargassum golden tides have bloomed frequently in many sea areas throughout the world, and negatively impacted on the local marine ecology. Sargassum muticum commonly inhabits rocky shores. It is now distributed worldwide due to its invasiveness, and recently drifting individuals have been observed on the coasts of Canary Islands. However, as a potential golden tide alga, physiological, and ecological studies of this species have not been frequently explored. To investigate the responses of S. muticum to light and nitrogen, two key environmental factors in golden tide formation, we established three light levels (LL, low light, 10 μmol photons m–2 s–1; ML, medium light, 60 μmol photons m–2 s–1, and HL, high light, 300 μmol photons m–2 s–1) and two nitrogen levels (LN, low nitrogen, 25.0 μM of natural seawater; HN, high nitrogen, 125.0 μM), and cultivated the thalli under different conditions for 12 days before measuring the physiological properties of alga. The results showed that higher light and/or nitrogen levels enhanced the relative algal growth rate. The maximum net photosynthesis rate of alga increased with the light, while it remained unaffected by the nitrogen. The HN treatment had no effect on the apparent photosynthetic efficiency of algae in the LL culture, while increased it in the ML and HL cultures. The irradiance saturation point of photosynthesis was approximately 300 μmol photons m–2 s–1 with no significant difference among the six treatments, except for a slight increase under HLHN in contrast to the LLHN and MLLN treatments. HL treatment decreased the maximum quantum yield of photosynthesis (Fv/Fm) in both nitrogen levels. In the HN culture, ML and HL led to lower values of photoinhibition, indicating higher survivability in the alga. The HN culture led to higher nitrogen uptake but had no effects on Fv/Fm and the contents of pigments and soluble protein, regardless of culture light level. Based on these results, we speculate that drifting individuals of S. muticum would be possible to form a golden tide owing to its rapid growth rate at light level of 300 μmol photons m–2 s–1, when they encountered the sustained lower light level on the sea surface (≤300 μmol photons m–2 s–1). A high nitrogen supply caused by eutrophication of seawater might facilitate this process. Our results provide an important reference for the prediction of golden tides formed by S. muticum.
Thermal Conductivity of Sodium Silicate Glasses and Melts: Contribution of Diffusive and Propagative Vibration Modes
Authors: Sukenaga Sohei , Endo Takahiko , Nishi Tsuyoshi , Yamada Hiroki , Ohara Koji , Wakihara Toru , Inoue Koji , Kawanishi Sakiko , Ohta Hiromichi , Shibata Hiroyuki
Published: November 2021

The thermal conductivity of silicate melts and glasses is an important physical property for understanding the temperature distribution in high-temperature metallurgical processes; however, the mechanism of heat conduction in these non-crystalline materials remains unclear. Two types of vibration modes must be considered to understand the mechanism of heat conduction, namely, propagative and diffusive vibration modes. In the present study, we carefully derived the thermal conductivity of pure silica and sodium disilicate glasses and melts, and estimated the contribution of the diffusive vibration mode using a recently developed model. The results indicated that the diffusive vibration mode was not dominant in the silicate non-crystalline materials, whereas the propagative vibration mode (i.e., phonons) was dominant in the heat conduction of silicate glasses and melts, which is in contrast with borate glasses.
Construction of Concave PdAg Nanoshells with Limited Thickness for Efficient Electroxidation of Ethanol
Authors: Wu Quanlin , Zhang Gongguo , Zhao Na , Zheng Yiqun , Ma Yanyun , Liu Feng , Liu Maochang
Published: November 2021

Noble metal nanocrystals enclosed with curved surfaces are of great benefit for applications in electrocatalysis since the atomic steps and kinks on these facets have higher chemical activity. Herein, we report the fabrication of PdAg nanoshells with tunable thickness in the range of 5–13 nm and a unique concave cubic morphology, as well as the exploration of their applications for ethanol oxidation reaction (EOR) in alkaline media. The success of current work relies on the conformal deposition of PdAg on concave Au nanocubes, where the controlled reaction kinetics and proper chosen capping agent are both crucial for the growth mode. When loaded on carbon black and working as electrocatalysts, they exhibited superb electrochemical activity (e.g., 600.21 mA mg−1 in mass activity and 19.57 A m−2 in specific activity), together with improved EOR kinetics and long-term durability, as compared to Au@Pd nanoparticles and commercial Pd/C. The current work offers a feasible strategy to produce PdAg bimetallic nanocrystals with concave surface and validates their promising application as fuel cell catalysts, which could be extended to morphology engineering of other noble-metal nanocrystals for a broad range of applications.
Impaired Microcirculation and Vascular Hemodynamics in Relation to Macrocirculation in Patients With Systemic Lupus Erythematosus
Authors: Svensson Christina , Eriksson Per , Bjarnegård Niclas , Jonasson Hanna , Strömberg Tomas , Sjöwall Christopher , Zachrisson Helene
Published: November 2021

Introduction: Systemic lupus erythematosus (SLE) is associated with premature cardiovascular disease (CVD) and mortality, unexplained by traditional risk factors. Impairment of microcirculation and vascular hemodynamics may represent early signs of vascular affection. We hypothesized that studies of microcirculation and pulse waves may provide additional information, compared to ultrasound (US) alone, for the detection of early vascular disease in SLE.

Methods: Sixty well-characterized SLE-patients (52 women, eight men; mean age 43.21 ± 1.3 years) characterized by lupus nephritis (LN; n = 20), antiphospholipid syndrome (APS; n = 20) or skin and joint involvement (n = 20) and 60 healthy controls were included. Microcirculatory peak oxygen saturation (OxyP) was evaluated using a novel combined laser Doppler flowmetry/diffuse reflectance spectroscopy method. Pulse waves were recorded in the radial artery by the aid of applanation tonometry in order to calculate central augmentation index (AIx75). Intima-media thickness (IMT) and plaque occurrence were evaluated using high frequency US, in carotid and central arteries.

Results: Lower OxyP (84 ± 8 vs. 87 ± 5 %, p = 0.01) and higher AIx75 (17.3 ± 13.9 vs. 10.0 ± 14.2 %, p = 0.005) were seen in the SLE cohort. OxyP was inversely correlated with IMT in internal carotid artery (ICA), (R = −0.32, p = 0.01). AIx75 correlated with IMT in common carotid artery (CCA), (R = 0.36, p = 0.005), common femoral artery (CFA), (R = 0.43, p = 0.001), and ICA (R = 0.27, p = 0.04). AIx75 correlated negatively with OxyP (R = −0.29, p = 0.02). SLE-patients with plaque had lower OxyP values (80 ± 8 vs. 85 ± 7 %, p < 0.001) and higher AIx75 (23.0 ± 11.6 vs. 15.5 ± 14.2 %, p < 0.001) compared to those without plaque.

Conclusion: Impaired microcirculation and vessel hemodynamics were observed in SLE. These methods correlated with IMT and plaque occurrence. The importance of early macro- and micro-circulatory vascular affection for increased risk of CVD in SLE will be followed-up in future studies.
Risk Factors and Management of Catheter Malfunction During Urgent-Start Peritoneal Dialysis
Authors: Zhao Lijuan , Yang Jun , Bai Ming , Dong Fanfan , Sun Shiren , Xu Guoshuang
Published: November 2021

Background: Catheter malfunction is a common complication of peritoneal dialysis (PD). This study aimed to retrospectively analyze the risk factors and management of catheter malfunction in urgent-start PD.

Methods: Patients who underwent urgent-start PD were divided into catheter-malfunction and control groups. Baseline demographic and laboratory data of the two groups were compared, and the risk factors for catheter malfunction were analyzed. Primary outcome measure was catheter survival, and the secondary outcomes were surgical complications and malfunction treatment.

Results: Total of 700 patients was analyzed, among whom 143 (20.4%) experienced catheter malfunctions, specifically catheter migration (96, 67.1%), omental wrapping (36, 25.2%), and migration plus omental wrapping (11, 7.7%). Catheter survival time in the malfunction group (202.5 ± 479.4 days) was significantly shorter than that in the control group (1295.3 ± 637.0 days) (P < 0.001). Multivariate analysis revealed higher body mass index [hazard ratio (HR), 1.061; 95% confidence intervals (CI), 1.010–1.115; P = 0.018], lower surgeon count (HR, 1.083; 95% CI, 1.032–1.136; P = 0.001), and higher serum potassium (HR, 1.231; 95% CI, 1.041–1.494; P = 0.036) as independent risk factors for catheter malfunction, while older age (HR, 0.976, 95% CI, 0.962–0.991; P = 0.002) and colonic dialysis (HR, 0.384; 95% CI, 0.254–0.581; P < 0.001) as protective factors. Further subgroup analysis revealed a shorter catheter survival time in patients with younger age ( ≤ 40 years), higher serum potassium levels (≥5 mmol/L), while a longer catheter survival time in patients with colonic dialysis. PD tube and subcutaneous tunnel preservation was successful in 41 out of 44 patients with omental wrapping. All patients had good post-incision prognoses.

Conclusions: Urgent-start PD is safe and effective for unplanned PD patients. Adequate pre-operative colonic dialysis and serum potassium level control are conducive in preventing catheter malfunction. Conservative treatment is effective in managing catheter migration alone, while preservation of the PD tube and the subcutaneous tunnel is effective for omental wrapping.