bluuebunny/crossref_metadata_2025 huggingface dataset:
Propuesta de Métricas para la implementación del estándar ISO/IEC 29110
Authors:   Centro de Investigación en Matemáticas- Unidad Zacatecas, Mejía Jezreel
Published: October 2022

El estándar ISO/IEC 29110 tiene como objetivo proveer y contribuir una serie de diferentes actividades, tareas y productos de trabajo que buscan mejorar la calidad de los diferentes productos de software desarrollado por Entidades Muy Pequeñas (EMPs). Sin embargo, la calidad no debe ser solo cualitativa sino cuantitativa a través del uso de métricas y aún en muchas EMPs existe el desconocimiento de la correcta aplicación de las diferentes métricas que pueden ser implementadas en este estándar. Este artículo presenta una propuesta de Métricas que apoyen a las EMPs en la implementación de este estándar y tener una visión cuantitativa en la calidad a nivel proceso, producto y proyecto. Para identificar las métricas viables, se analizaron dos proyectos presentados por dos EMPs para obtener su certificación, identificando el conjunto de métricas a través de la documentación presentada por las EMPs.
La inteligencia artificial en la Psicología: nuevos enfoques para la detección de las declaraciones falsas
Authors:   Posgrado de la Facultad de Ingeniería de Sistemas e Informática, Altamirano-Yupanqui Josue R. , Bernuy-Alva Augusto ,   Universidad de San Martin de Porres
Published: October 2022

Las mentiras a través de las declaraciones falsas tienen consecuencias negativas por los daños y perjuicios a personas e instituciones inocentes que son involucradas o por los beneficios indebidos que persiguen ciudadanos deshonestos. En las investigaciones las declaraciones son utilizadas para obtener información sobre los hechos y la detección temprana de su falsedad representa un desafío. Los instrumentos que dispone el profesional de psicología para detectar la falsedad tienen altas tasas de error y con mucho retraso en brindar resultados debido al estudio individual de los implicados. Proponemos nuevos enfoques basados en inteligencia artificial como un nuevo mecanismo a las técnicas psicológicas existentes para la detección temprana de la falsedad en las declaraciones escritas. Los resultados preliminares demuestran la viabilidad de la Inteligencia Artificial para la predicción de la falsedad, lo que permitirá que el profesional de psicología disponga de nuevas herramientas en el proceso de la detección de mentiras.
As águas onde pescam as mulheres: uma análise das invisibilidades e desigualdades na atividade pesqueira nos municípios produtores de Petróleo da Bacia de Campos
Authors: Souza Joseane de , Marinho Azula Marina Couto
Published: October 2022

Partindo do conceito ampliado de pesca artesanal, que inclui todas as atividades necessárias para a captura do peixe, para a coleta e/ou cultivo de algas e mariscos, e para a comercialização de todo o pescado, a presença de mulheres na pesca artesanal, na Bacia de Campos, é indubitável. Porém, nesse segmento do mercado de trabalho, há forte divisão sexual e social do trabalho e apesar das mulheres exercerem atividades fundamentais em todas as etapas da cadeia produtiva, o trabalho feminino é marcado por grande invisibilidade e desvalorização pela categoria, pelo mercado e pelo Estado. Este trabalho busca compreender as especificidades da invisibilidade das mulheres na pesca, no contexto dos municípios produtores de petróleo da Bacia de Campos e, para tanto, analisa as diferenças entre homens e mulheres na pesca artesanal, em três dimensões - mercado de trabalho, vida domiciliar e participação política – a partir dos dados do Censo Pescarte. Os resultados mostram haver grande desigualdade de gênero no interior do mercado de trabalho da pesca artesanal na Bacia de Campos e apontam a necessidade da implementação de políticas de gênero que possam alterar as estruturas de poder e as relações de gênero que se processam no interior das comunidades e do mercado de trabalho da pesca, de forma a dar maior visibilidade e protagonismo às mulheres na pesca.
Ambiente institucional e renda individual: uma aplicação multinível
Authors: Ribeiro Hilton Manoel Dias , Bastos Suzana Quinet de Andrade , Hermeto Ana Maria
Published: October 2022

O objetivo deste artigo é avaliar como as instituições, seja no nível do indivíduo ou no nível mais agregado (países), se relacionam com uma medida categórica de renda individual. Para atendê-lo, dado que se incluem variáveis em diferentes níveis, lança-se mão do modelo de regressão logística hierárquico, tendo a categoria de renda individual como variável dependente. Os resultados indicam que dimensões institucionais como família, confiança, igualdade de gênero, interesse por política e democracia, competição e tamanho de governo, apresentam-se positivamente relacionadas à renda mais alta. De outra forma, dimensões institucionais como religião, obediência, autoridade e igualdade de renda apresentam-se inversamente relacionados à categoria de renda mais alta. Além disso, sobre as instituições formais no nível agregado (países), sugere-se a associação positiva entre melhores garantia de direito de propriedade, menor tamanho do governo e alta medida de renda individual. Esses resultados revelam que ambientes institucionais que valorizam a confiança, a democracia e os direitos de propriedade podem influenciar diretamente na determinação do nível de renda per capita.
Desvio, problematização e solidariedade como atributos de criação de lugares sustentáveis
Authors: Mehmood Abid , Marsden Terry
Published: October 2022

Este documento tem como objetivo avançar uma visão conceptual e analítica da apreciação e conectividade dos espaços, lugares e natureza na reconceitualização e progresso das transições de sustentabilidade. Analisamos as inter-relações entre as abordagens distintas de integração de práticas socialmente inovadoras, problematização através de traduções inovadoras, e ancoragem de traduções sustentáveis através de assembleias solidárias. Estas três dimensões permitem-nos desenvolver uma perspectiva neocallonista para a construção de um lugar e tradução sustentáveis na ciência da sustentabilidade. Referimo-nos a algumas experiências empíricas para apreciar estas inter-relações que contribuem para novas realidades e criam novos espaços e lugares de inovação.
Projeto Governo Cidadão e o enfoque em Arranjos Produtivos Locais: uma análise dos limites da abordagem no Rio Grande do Norte
Authors: Fernandes Vinícius Rodrigues Vieira , Jesus Clesio Marcelino de
Published: October 2022

A abordagem de desenvolvimento pautada na constituição de Arranjos Produtivos Locais (APLs) tem, ao longo dos anos, despertado o interesse de diversas instituições, como o Banco Mundial, que vem recomendando a sua adoção no âmbito das políticas públicas. O estado do Rio Grande do Norte passou a adotar este enfoque no Projeto Governo Cidadão. À luz do contexto econômico, social e político de espaços deprimidos, questionam-se os limites que se apresentam para as políticas públicas ao adotarem a abordagem de APL como estratégia para o desenvolvimento territorial. Busca-se discutir os principais problemas de se institucionalizar a ideia de APL como instrumento de política pública no Rio Grande do Norte. A construção teórica respalda-se sobre a noção de APLs, a inserção desta abordagem na agenda de desenvolvimento do Banco Mundial e a apresentação do Projeto Governo Cidadão. Utiliza-se, na análise, dados secundários presentes na literatura, bem como lança-se mão de entrevistas semiestruturadas, grupos focais e observações simples e participante, tomando-se como referência um estudo de caso, o território Açu-Mossoró. Identificam-se importantes aspectos limitantes, dentre os quais, a falta de um conceito aglutinador de APL, a reduzida geração de economias externas e o baixo nível de capital social e governança. Conclui-se que é preciso refletir sobre a relação entre espaços subnacionais e organismos multilaterais. Ademais, o enfoque em APLs exige um processo pautado na participação efetiva do Estado.
Assessment of the Spatial Heterogeneity of Economic Activity in the Municipalities of Sverdlovsk Oblast
Authors:   Institute of Economics of the Ural Branch of RAS, Naumov I. V. , Nikulina N. L. ,   Institute of Economics of the Ural Branch of RAS
Published: October 2022

Uneven socio-economic development of municipalities in various regions depends on many factors, in particular, on the peculiarities of the distribution of economic entities and their activities. We hypothesise that this heterogeneity increases due to unequal distribution of labour and investment resources. In order to test this hypothesis, the study assesses the impact of the distribution of personnel and investment resources in the municipalities of Sverdlovsk oblast on the spatial heterogeneity of economic activity. To this end, the methods of regression and spatial autocorrelation analysis were used. The developed methodology involves assessing the spatial heterogeneity of economic activities of various enterprises in territorial systems. Spatial regression analysis was applied to examine the impact of labour and investment resources on the heterogeneity dynamics, while spatial autocorrelation analysis was used to consider the distribution of these factors. Due to the systematic use of spatial autocorrelation analysis for various spatial weights matrices, as well as regression analysis based on panel data and geographically weighted regression, the degree of the influence of factors on the heterogeneity of economic activities in certain municipalities was established. Testing of the presented methodology revealed a trend towards an increase in the spatial heterogeneity of economic activity, its concentration in Ekaterinburg, Nizhny Tagil, Kamensk-Uralsky, as well as in Verkhnyaya Pyshma, Pervouralsk, Verkhnesaldinsky, Polevskoy, Revda, Kachkanarsky, Berezovsky, Zarechny and Serovsky urban okrugs in the period from 2017 to 2020. The Cobb-Douglas model showed that the main factor contributing to the increase in the spatial heterogeneity of the economic entity activity is labour costs; the volume of attracted investments plays an important role in municipalities with a high concentration of shipped goods and rendered services. Based on the model modified using geographically weighted regression, the study established a degree of spatial influence of the examined factors on the economic activity and, together with a spatial autocorrelation analysis of the distribution of human resources and investments in the municipalities of the region, to confirm the hypothesis put forward.
Factors of Export Diversification: Empirical Analysis of Russian Industrial Regions
Authors:   Ural Federal University, Vasilyeva R. I. , Mariev O. S. ,   Ural Federal University, Voytenkov V. A. ,   Ural Federal University, Urazbaeva A. R. ,   Ural Federal University
Published: October 2022

Oil and gas dependence and the volatility of their prices is currently a serious challenge for the Russian economy. Coincidently, export revenues from oil and gas products are the main source of the federal budget. Export diversification can contribute to risk reduction for the Russian economy by increasing the share of products from other industries in the export structure. In this regard, the present study examines the determinants of export diversification in Russian industrial regions using econometric modelling methods. To this end, the Herfindahl and Theil indices for 97 export groups were calculated. It is hypothesised that the development of small and medium-sized enterprises, as well as the sanctions imposed by Western states against Russia are the main factors of export diversification in industrial regions. Simultaneously, natural resource extraction is assumed to significantly increase the concentration of exports in the regions. To test this hypothesis, panel data of 50 Russian industrial regions for the period 2001-2019 were analysed. The quantile regression approach was applied to solve the heteroscedasticity problem. Three groups of regions were distinguished according to their level of diversification: regions with a high level of export diversification (Q10-Q30), with an average level of diversification (Q40-Q60), with a low level of export diversification (Q70-Q90). The research findings show that the development of small and medium-sized enterprises contributes to export diversification in Russian industrial regions. While the sanctions did not have a significant impact on export diversification, regional potential and natural resource extraction increase the concentration of exports. The obtained study results complement the existing literature on export diversification in Russia, and contribute to the development of policy implications.
Heterogeneous Effects of Individual Socio-Economic Characteristics and Regional Environmental Conditions on Self-Reported Health
Authors:   HSE University, Leonova L. A. , Lakshina V. V. ,   HSE University, Aladyshkina A. S. ,   HSE University
Published: October 2022

Health is a comprehensive phenomenon with many determinants. The influence of environmental conditions on human health poses challenges for public health scientists. One of the main issues is the availability and relevance of the data on public health, including such indicators as morbidity and decease prevalence. In this study, we overcome this obstacle by using micro data on self-reported health from the Russia Longitudinal Monitoring Survey of Higher School of Economics. The study analyses the influence of environmental conditions on individual self-rated health in Russia, taking into account the heterogeneity of coefficients among self-rated health levels. We used generalised ordered probit model with random effects and embedded procedure for parallel line assumption violation testing. The characteristics of air, water and the quantity of pollutants in each region were considered as independent factors. The study showed significant negative influence of environmental factors on self-rated health throughout Russia. It is also demonstrated that higher self-rated health estimates are given by respondents whose level of education is no lower than that of vocational or trade school, who are married, and who are regularly engaged in physical activity. The results obtained can be used to improve regional state programmes aimed at improving the quality of life of the population in groups with different levels of health, for example, to the development and targeting of a set of health policy measures. Additionally, these findings can be utilised in programmes to improve the quality of the environment, which can increase the overall level of self-assessment of health in a particular region.
Testing Unemployment Hysteresis with Multi-Factor Panel Unit Root: Evidence from OECD Countries
Authors:   Abant Izzet Baysal University, Konat G. , Coşkun M. F. ,   İnönü University
Published: October 2022

Hysteresis is a dominant feature of unemployment in numerous countries. According to the hysteresis hypothesis, it is a well-known fact that high unemployment may persist and remain an economic threat in the long run if policy measures are not taken. In this study, it is tested whether the unemployment rates for 10 selected countries of the Organisation for Economic Co-operation and Development (OECD) (Belgium, Canada, Czech Republic, Estonia, France, Japan, Netherlands, Spain, Britain and the USA) contain unit root or not, in other words, whether the hysteresis effect is valid for these countries. For this purpose, this study utilises the concept of the multi-factor panel unit root test proposed by Pesaran, Smith and Yamagata. This method measures cross-section dependence through factors. The test analyses whether the unit root is valid or not, using information about a sufficient number of additional explanatory variables. The characteristic of these additional variables is that they must share a common factor with the variable whose stationarity is tested. It is accepted that this common factor causes cross-sectional dependence. We have taken tax wedge, trade union density and minimum wage as factors that cause cross-sectional dependency and affect unemployment hysteresis. In this test developed by the authors, in the case of a multi-factor error structure, the test procedure is completed by using the information contained in 3 additional variables. The study explores not only the validity of unemployment hysteresis but also the factors that affect the rigidity of the unemployment rate. However, the research was unable to encompass the entire OECD countries and all times because of the lack of data. The results showed that the hysteresis is valid for 10 selected OECD countries.
Characterisation of a Standard Fan Test Facility to Accommodate Reflection of Sound During Noise Measurements
Authors: du Plessis C. , Van der Spuy S.J. , Reuter H.C.R.
Published: October 2022

Axial flow fans are fundamental to air-cooled condensers. While they provide the air flow for heat transfer, they also generate noise, which is a growing environmental concern. Sound reflections are characterised in an existing fan performance test facility, which does not conform to fan noise measurement standards. Corrections to the measured SPL spectrum is deduced along with the uncertainty in noise measurements. Corrections are compared to a reflection correction standard relating to buildings. This methodology can be repeated for other fan test facilities which do not comply with noise measurement standards.
Dielectric Elastomer Actuators and Optical Character Recognition in a Braille Display
Authors: Botha I.R. , Bright G. , Collins J.E.T.
Published: October 2022

The purpose of this study was the development and experimental validation of a novel portable tactile braille reading device. This design aimed to address the lack of quality braille reading material in South African schools dedicated to the blind and visually impaired. The design was divided into four subsystems: the actuation of the refreshable braille display, the mechanical design of the hand mounted device, the Optical Character Recognition (OCR) software and the electronic control system. The objectives of the study included the design of the electrical, mechanical and software subsystems of the device with emphasis on miniaturisation and a low-cost design, as well as the experimental validation of the haptic feedback and OCR subsystems. The system validation focussed on the experimental analysis of the OCR software design and the Dielectric Elastomer Actuators (DEAs) utilised in the refreshable display. The performance of low-cost elastomer and electrode materials were experimentally assessed during the design of the miniature DEAs. The ideal material combination for the proposed application was identified as a VHB4910 acrylic film lined with MG Chemicals 846 carbon grease. The largest vertical deflections of the diaphragm-type DEA were attained with a stipple-based electrode application, with the elastomer prestrained to 300 % initial area. The OCR program analysis indicated that multiple character recognition was more efficient and less prone to inaccuracies than the initially proposed single character recognition method. The integration of OCR software with miniature DEAs served as a novel approach to text-to-braille transcription.
Crónica íntima y política de una metamorfosis
Authors: CAPLAN Raúl
Published: October 2022

"Volverse Palestina" es n texto híbrido, a la vez testimonio, ensayo, crónica, diario íntimo, relato de viaje y panfleto, En sus páginas, la escritora chilena Lina Meruane hace más que dar cuenta de un viaje exploratorio de sus raíces. De manera sensible, poética y argumentada, va dando cuenta de los cambios que se han ido produciendo en su ser al explorar esos orígenes, asumirlos y emprendar una metamorfosis a la vez íntima y política.
Yield, profitability and agronomic efficiency of nitrogen in rainfed maize with complementary foliar fertilization of Zn and Mo
Authors: Muñoz Líder , Cedeño George , Cedeño Galo , Avellan Benny
Published: October 2022

The research aimed to evaluate the effect of complementary foliar applications of Zn and Mo on the yield, profitability, and agronomic efficiency of nitrogen in rainfed maize. The work was carried out during the rainy seasons of 2020 and 2021 in the Carrizal river valley, Manabí, Ecuador. The treatments evaluated were: NPK soil fertilization supplemented with foliar application of Zn and Mo (T1) and NPK soil fertilization without foliar application of Zn and Mo (T2). Grain yield (RG), agronomic efficiency of N (EAN), and the net economic benefit of fertilization (BEN) were recorded. Data were analyzed with Student's t-test for paired observations. Treatment T1 increased the RG by 15.58% and 14.03% during 2020 and 2021, respectively, concerning treatment T2. Similarly, the T1 treatment increased the EAN by 28.30% and 24.60% in the 2020 and 2021 seasons, respectively, concerning the T2 treatment. Finally, treatment T1 produced the highest BEN, with an increase of 23.05% and 16.37%, during 2020 and 2021, respectively, about treatment T2. Complementary foliar fertilization with Zn and Mo enhanced the effect of NPK soil fertilization and increased yield, profitability, and EAN in rainfed maize.
Characterization of preening from male Leistes bellicosus at Jaén airport, Perú
Authors: Azabache Javier , Marcial Ronald
Published: October 2022

Preening in birds is a biologic aspect very important, its allow to ensure their welfare through the maintenance from external parts of theirs body. In relation to that was numerically characterized the preening of male Leistes bellicosus (specie most hit by airplanes Jaen aerodrome), between February and July 2022 at Jaén airport. A continuous recording for 2 hours and focal behavior for 5 minutes was performed, also using the fuzzy logic algorithm and exploratory analysis to measure this behavior. The preening is characterized by having a frequency between 1-4times/5minutes, a duration concentrated mainly between 1-50 seconds and an intensity of 4.7 points (Membership function=0.8). These variables have no correlation with temperature, humidity, wind speed and cloudiness. The wings and the back are the structures that are most cleaned (29 and 21 times/80 observations, respectively).
CompetentCell v1
Authors: Belem García González Ana
Published: October 2022

A protocol for making chemically competent cells is shown.
Klasik Elit Teorisyenlerinde Makyavelist İzler
Authors: YALÇIN Muhammed Akif
Published: October 2022

Bu çalışmanın amacı Siyaset sosyolojisi disiplini içerisinde ele alınan elit teorileri ve seçkinci yaklaşımların klasik temsilcileri olan Pareto, Mosca ve Michels’in yaklaşımlarına İtalyan düşünür Machiavelli’nin etkisini incelemektir. Siyasal açıdan yönetim biçimlerini şekillendiren, çoğunluk-azınlık ilişkileri, güçlü ve etkili olanın yönetimde sahip olduğu pay, iktidarın toplumsal kabulünü sağlayan nedenler ve bu nedenlerin meşrulaştırılması elit teorilerinin kapsamına girmektedir. Elit teorisyenlerinin üzerinde durduğu bazı kavramlar Machiavelli’nin öğretilerinde ileri sürdüğü temel kavramlarla ilişkilidir. Bu kavramlar ve kullanıldığı bağlamlar güçlü olmaya, kurnaz olmaya ve sahip olunan statünün korunmasına vb. ilişkindir. Makyavelist tutum ve yöntemlerin elit teorilerinin oluşumundaki etkilerinin incelenmesinin, klasik elit yaklaşımlarının farklı bir perspektiften irdelenmesine imkân vereceği düşünülmektedir.

Sosyolojik bir kavram olarak irdelenen “eşitsizlik” ve buna bağlı olarak temellenen “tabakalaşma” kavramının siyasal alandaki izdüşümünün elit teorilerinin yardımıyla incelenmesi hem sosyoloji hem de siyasal bilimler açısından önemlidir. Zira seçkin-elit yaklaşımların arka planındaki Makyavelist felsefe siyasal tabakalaşmanın sistematiğini ana hatlarını aydınlatmaktadır.

Bu çalışmada birincil ve ikincil kaynakların incelendiği ve düşünürlerin görüşlerinin karşılaştırmalı olarak sunulduğu bir yöntem benimsenmiştir. Dolayısıyla öncelikle Machiavelli’nin eserlerinde ileri sürdüğü görüşlerinden hareket edilerek teorik arka plana dair bilgi verilmiştir. Ardından yukarıda isimleri geçen düşünürlerin elit teorilerine yaptıkları katkıları karşılaştırmalı olarak ele alınmıştır.
Design Simulation and Analysis of Deep Convolutional Neural Network Based Complex Image Classification System
Authors: Rajput Bhumika Singh , Gangele Anshul , Alaria Satish Kumar , Raj Ashish
Published: October 2022

There are 350 families and over 250,000 known varieties of flowering plants. Furthermore, effective flower classification, including content-based image recovery, is essential for the order, plant inspections of buildings, the gardening sector, live plantations, and scientific flower classification guidelines. The representation of flowers has a broad variety of uses. However, manual categorization is time-consuming and exhausting, particularly when the image basis is confusing, has a large number of images, and is perhaps erroneous for several flower groupings. Therefore, effective flower division, discovery, and categorization processes are of great significance. To ensure robust, trustworthy, and ongoing characterization during the preparation stage, new approaches are proposed in this work. On three datasets of flowers that are undeniably known, our technique is tested. Results that are better than the best in this aim for all data sets with accuracy over 98 percent. The categorization of flowers from a wide variety of animal groups is attempted in this research using a unique two-way deep learning method. In order for the foundation box to be placed around the floral area, it was first separated into sections. In a system that uses just convolutional networks, the suggested method for floral distribution is shown to be a parallel classifier. Make a powerful classification using convolutional neural networks in order to recognize the various flower types.
Numerical Simulation and Assessment of Meta Heuristic Optimization Based Multi Objective Dynamic Job Shop Scheduling System
Authors: Rajput Bhumika Singh , Gangele Anshul , Alaria Satish Kumar
Published: October 2022

In today's world of manufacturing, cost reduction becomes one of the most important issues. A successful business needs to reduce its cost to be competitive. The programming of the machine is playing an important role in production planning and control as a tool to help manufacturers reduce their costs maximizing   the   use   of   their   resources.   The   programming problem is not only limited to the programming of the machine, but also covers many other areas such such as computer and information technology and communication. From the definition, programming is an art that involves allocating, planning the allocation and utilization of resources to achieve a goal. The aim of the program is complete tasks in a reasonable amount of time. This reasonableness is a performance measure of how well the resources   are   allocated   to   tasks.   Time   or   time-dependent functions are always it used as performance measures. The objectives of this research are to develop Intelligent Search Heuristic algorithms (ISHA) for equal and variable size sub lot for  m  machine  flow  shop  problems,  to  Implement  Particle Swarm Optimization algorithm (PSO) in matlab, to develop PSO based Optimization program for efficient job shop scheduling problem. The work also address solution to observe and verify results of PSO based Job Shop Scheduling with help of graft chart.
ANALYSIS OF DETECTION AND REGISTRATION OF INFECTIONS RELATED TO MEDICAL CARE IN THE URAL AND SIBERIAN FEDERAL DISTRICTS IN 2021
Authors: Smirnova Svetlana S. , Egorov Ivan A , Malkova Elena V. , Zhuikov Nikolai N. , Shelkova Elena S. , Zainagabdinova Yulia R. , Semenov Aleksandr V
Published: October 2022

Despite of significant advances in the development of healthcare as well as the introduction of new safe diagnosis and treatment technologies of various diseases, the problem of preventing health care-associated infections (HAIs) does not lose its relevance.
The article presents an data analysis of officially registered HAIs cases within medical organizations of Ural and Siberian Federal Districts. The analysis was carried out on the basis of data from Federal Statistical Observation Forms No. 2 "Information on infectious and parasitic diseases", No. 23-17 "Information on outbreaks of infectious diseases" and additional request materials "Information on medical manipulations and contingents treated" for 2021 and in dynamics for 7 years (2015-2021) in comparison with indicators for whole Russian Federation.
Statistical data were provided by the Departments of Rospotrebnadzor from Irkutsk, Kemerovo, Kurgan, Novosibirsk, Omsk, Sverdlovsk, Tomsk, Tyumen, Chelyabinsk regions; Altai, Transbaikal, Krasnoyarsk Territory; republics of Altai, Buryatia, Tyva, Khakassia; Khanty-Mansi Autonomous Okrug Yugra, Yamalo-Nenets Autonomous Okrug. Data for Russian Federation were provided by Federal Center for Hygiene and Epidemiology of Rospotrebnadzor according the duties of Ural-Siberian Scientific and Methodological Center for the Prevention of Health Care-associated Infections.
Based on the analysis results the rating assessment of HAIs detection and registration quality in subjects of Ural and Siberian Federal Districts and the ranking of subjects taking into account the HAIs epidemiological surveillance system functioning activity was carried out. The information presented in the article is intended for employees of Rospotrebnadzor bodies and organizations, medical organizations, educational organizations, executive authorities in the field of healthcare.
The effect of polymorphic alleles carriage of the VKORC1 gene on clinical and laboratory ­parameters in patients with acute coronary syndrome
Authors: Kantemirova Bela I. , Chernysheva Elena N. , Orlova Ekaterina A. , Abdullaev Musalitdin A. , Petrova Olga  V. , Rostoshvili Giorgi A.
Published: October 2022

Background. The role of the VKORC1 (1639GA, rs9923231) gene polymorphism in hypersensitivity to warfarin and hypocoagulation is known. It has been proven that polymorphisms in the VKORC1 gene can lead to the progression of atherosclerosis and hypercoagulability, and, therefore, can be factors contributing to the development of acute coronary syndrome.
Aim. To study the effect of polymorphic genotypes carriage of the VKORC1 gene on the clinical and laboratory parameters of patients with acute coronary syndrome.
Material and methods. The pilot observational cross-sectional study involved 77 patients who were under observation in the conditions of the Federal Center for Cardiovascular Surgery in Astrakhan and the vascular center of Kirov City Hospital No. 3 (Astrakhan), from October 2020 to May 2021. Genotyping for CYP2C9, VKORC1, CYP4F2 on a PCR analyzer was performed. For statistical processing, the HardyWeinberg and Student criteria; 95% confidence interval were determined using Statistica Trial 13 and IBM SPSS Statistics 26.0. Differences were considered statistically significant at p 0.05.
Results. Significant differences related to the frequency of hemodynamically significant stenosis in homozygous carriers of the GG gene for VKORC1 compared with the group of carriers of the GA genotype 3 (8.8%) versus 7 (22.5%); p=0.0058. Carriers of the GA and GG genotypes were most often diagnosed with myocardial infarction (Q- and non-Q-forming). Carriers of the AA genotype were more likely to have new or progressive angina pectoris. The level of hyperglycemia and triglyceridemia was the highest in the group of patients with the AA genotype, VKORC1 gene.
Conclusion. Statistically significant differences were established in the clinical and laboratory parameters of patients with acute coronary syndrome, carriers of different genotypes of the VKORC1 gene.
Inhibitory effect of DL-butionine sulfoximine on P-glycoprotein activity in vitro
Authors: Abalenikhina Yulia V. , Mylnikov Pavel Yu. , Shchulkin Alexey V. , Yakusheva Elena N.
Published: October 2022

Background. P-glycoprotein (Pgp) is a multidrug resistance protein 1 with broad substrate specificity. Its functioning can change under the influence of various substances, so the search for endogenous and exogenous compounds that modulate the activity of the transporter protein is an important area of research.
Aim. To evaluate the effect of DL-butionine sulfoximine on the activity and amount of the Pgp transporter protein in Caco-2 cells.
Material and methods. The study was performed on a human colon adenocarcinoma cell line (Caco-2). Cells were incubated with DL-butionine sulfoximine and quinidine (a classical Pgp inhibitor) at concentrations of 1, 5, 10, 50, 100, and 500 M for 3 hours. Pgp activity was evaluated by the transport of its substrate, fexofenadine, which concentration was determined by high performance liquid chromatography with ultraviolet detection (Stayer, Russia). The results were analyzed using StatSoft Statistica 13.0 (ANOVA), IC50 was calculated using GraphPad Prism 8 software. Differences were considered statistically significant at p 0.05.
Results. Incubation with DL-butionine sulfoximine and quinidine at concentrations of 1500 M for 3 hours did not affect the amount of Pgp in Caco-2 cells. Pgp activity decreased when using DL-butionine sulfoximine at concentrations of 50500 M by a maximum of 47.7% (p=0.040). Quinidine at concentrations of 5500 M reduced Pgp activity by a maximum of 79.1% (p=0.0002) at a concentration of 500 M. Quinidine inhibited Pgp activity at lower concentrations compared to DL-butionine sulfoximine: the IC50 of fexofenadine with quinidine was 5.160.59 mol/l, for DL-butionine sulfoximine it was 17.212.46 mol/l (p= 0.001).
Conclusion. DL-butionine sulfoximine has a direct inhibitory effect on the activity of the Pgp transporter protein on the Caco-2 cell line.
Economic assessment of the high-tech and primary health care technologies for coronary heart disease according to personalized accounting of medical care for compulsory health insurance
Authors: Nazarov Alexander M. , Saifutdinov Rustam I. , Sayfutdinov Farkhad R.
Published: October 2022

Background. The assessment of medical technologies based on digital information is prompt and accurate, but it is currently not widely used, and analysis methods for this have not been developed, which became the basis for this study.
Aim. To economically evaluate the technologies of reperfusion therapy and dispensary observation in coronary heart disease using electronic data on medical care.
Material and methods. 586 patients with myocardial infarction treated in 2016 in two vascular centers of the Orenburg region were identified according to the registers-accounts of the compulsory health insurance fund. Among them were 349 patients with reperfusion therapy (main group) and 237 without it (control group). In the groups, the cost-effectiveness indicator, the cost of inpatient treatment of myocardial infarction and treatment in the postinfarction period were determined. Also, according to the registers-accounts for 2016, 17 225 patients with angina pectoris were identified. Among them, 13 208 patients, who applied to polyclinics for dispensary purposes during 20162017, and 4017 patients who did not apply, were registered the main and control groups. Between groups, the total cost of outpatient, emergency, emergency hospital care and the cost-effectiveness ratio were compared. When processing the data, linear statistics methods and parametric comparison methods (Student's t-test and z-test) were used.
Results. The cost-effectiveness indicator in the group with reperfusion therapy was 425 879, without it 643 069 rubles/unit, 1.5 times more in the control group. In the postinfarction period, the cost of treatment in the main group was lower than in the control group, 1223.6619.04 and 1321.1121.15 rubles, respectively, for outpatient care (p=0.001), 35 138.91299.85 and 51 189.64903.15 rubles for inpatient care (p=0.002), 4093.058.98 and 5428.652.95 rubles for an ambulance (p=0.001). The cost of angina treatment in the main group was 2.1 times less than in the control group, 6541.385.58 and 13 671.492.12 rubles (p=0.001). The cost-effectiveness indicator in the main group was 6867, in the control group it was 15 293 rubles/unit, 2.2 times more in the control group.
Conclusion. The use of reperfusion therapy and dispensary observation in coronary heart disease is economically feasible.
Principles of modeling brain diseases and their therapy based on zebrafish studies
Authors: Kalueff Allan V.
Published: October 2022

Here, we introduce the multidisciplinary readers of the present specialized issue of the journal to the significance and principal approaches to modeling various brain disorders in laboratory fish species the zebrafish (Danio rerio).
Despair-like behavior in fish based on the zebrafish (Danio rerio)
Authors: Galstyan David S. , Kolesnikova Tatyana O. , Kositsyn Yurii M. , Zabegalov Konstantin N. , Gubaidullina Mariya A. , Maslov Gleb O. , Demin Konstantin A. , Kalueff Allan V.
Published: October 2022

The zebrafish tail immobilization test is a relatively new method for analyzing zebrafish behavior, based on the paradigm of learned helplessness, when the animal is exposed to an uncontrollable stressor, and soon abandons all attempts to avoid the aversive stimulus, adopting a posture of immobility. As an aversive stimulus acts restraining fish tail in a viscose sponge, without restricting the mobility of the lateral fins and the front of the body. The zebrafish tail immobilization test is suitable for detecting depressive-like despair behavior in zebrafish, paralleling clinical apathy and lethargy in depression.
Modeling the drug withdrawal syndrome in zebrafish (Danio rerio)
Authors: Zabegalov Konstantin N. , Galstyan David S. , Kolesnikova Tatyana O. , Kositsyn Yurii M. , Gubaidullina Mariya A. , Maslov Gleb O. , Demin Konstantin A. , Khatsko Sergey L. , Kalueff Allan V.
Published: October 2022

The central pathological link in addictive states is the drug withdrawal syndrome. Usually, severe manifestations of the withdrawal syndrome are associated with reduced sensitivity of postsynaptic receptors (desensitization), lower density of receptors and impaired transport of neurotransmitters, and the rebound effect. Zebrafish is an effective tool in the study of classic withdrawal symptoms and special cases of withdrawal of other selected psychoactive drugs.
The influence of the extract of Panax ginseng on the behavior of chronically alcoholized Danio rerio during ethanol withdrawal
Authors: Airapetov Marat I. , Eresko Sergei O. , Galustyan Anna N. , Lebedev Andrei A. , Shabanov Petr D.
Published: October 2022

BACKGROUND: The search for new ways to correct the pathophysiological mechanisms underlying the alcohol withdrawal syndrome is an urgent and promising direction in the pharmacotherapy of alcoholism. The extract of Panax ginseng is of interest in relation to the correction of pathological behaviors caused by long-term alcohol consumption. With the help of behavioral tests, you can evaluate the features of various forms of behavior.
AIM: To study the effect of Panax ginseng extract solution on the behavior of Danio rerio fish during the period of alcohol withdrawal after prolonged alcoholization.
MATERIALS AND METHODS: Prolonged alcoholization was modeled by placing the fish in an aquarium with 0.3 ethanol solution for 14 days. After the abolition of ethanol, intraperitoneal injections of Panax ginseng root extract solution (0.3 mg / 1 g) were performed for 7 days. The behavior of fish was studied in the test Motor activity in a new place and after habituation.
RESULTS: The article presents the results of the effect of Panax ginseng extract solution on the behavior of Danio rerio fish during the period of alcohol withdrawal after prolonged alcoholization. The time spent in sections in the Panax ginseng (0.3 mg / 1 g) injection group was restored to control levels compared to the alcohol withdrawal group of fish injected with saline.
CONCLUSIONS: The study showed that the behavior of Danio rerio fish in the test Motor activity in a new place and after habituation was subject to changes, while the Panax ginseng extract recover the behavioral changes of the fish up to control indexes.
Digitalization of railway station complexes
Authors: Nikonova Yana I. , Proskuryakova Elena A.
Published: October 2022

Background: Digital railway is the most important global trend in the development of railway transport. Smart station is part of the digital railway concept. Currently, there is no unambiguous solution to the problem of how to introduce advanced information technologies to improve the efficiency and level of service of the railway transport system in the station complexes. The construction of new and reconstruction of existing station complexes in accordance with the concept of smart station is also relevant for Russian railways.
Aim: identify priority areas for the development of station complexes; to characterize the main measures for the digitalization of the management system of railway stations of Russian Railways.
Materials and Methods: in the course of the study, a systematic approach, analysis, synthesis, methods and tools for statistical data processing were used: tabular method, methods for calculating average and relative values, methods for analyzing dynamics. Activities for the digitalization of station management systems were evaluated on the basis of methods for evaluating the effectiveness of investment projects in the field of railway transport. The information base consists of the works of domestic and foreign scientists in the field of digitalization of railways, the development of railway stations, as well as strategic documents of Russian Railways: Long-term program for the development of railway stations of the Directorate of Railway Stations a branch of Russian Railways for the period up to 2025; The concept of efficient use and development of railway stations for the period up to 2030; Development strategy of the Russian Railways holding for the period up to 2030; Long-term development program of Russian Railways until 2025.
Results: the world trends in the development of station complexes are considered; clarified the essence of the category smart station; the characteristics of the main directions of digitalization of the station complexes of Russian Railways are given.
Conclusion: the concept of smart station is the basis for changes in the organization of the activities of station complexes being implemented in modern conditions. The introduction of digitalization contributes to an increase in the efficiency of all types of activities of the station complexes of Russian Railways.
Ritual Economy, or How Much Is Spent on A Wedding in Central Asia
Authors:   HSE University, Barsukova Svetlana Yu.
Published: October 2022

The article describes the rituals that form a complex of wedding traditions in the countries of Central Asia. We are talking about rites (pre-wedding, wedding and post-wedding) and related expenses. Observance of traditions imposes heavy financial obligations on the families of the bride and groom, driving them into credit burden and depriving them of economic well-being for many years. Why do families participate in this wasteful excess? What drives them? The article focuses on decoding the institute of Central Asian wedding. The article is based on interviews with students from Central Asian countries studying in Moscow. Arrival in Moscow indicates a willingness to accept values conventionally called "Western". Representatives of the westernized youth critically evaluate the economy of weddings, seeing no sense in following traditions that condemn families to excessive waste. In their opinion, the reproduction of the ritual economy is supported by public opinion and is based on the fear of the family to spoil the reputation. The wedding turns into an act of demonstrative generosity, which confirms the social status of families.Students reconstruct the logic of parents in terms of being forced to follow certain rules under vigilant social control: the rule of the reciprocal exchange of gifts; demonstration of social status and maintaining the prestige of the family; competition between the families of the bride and groom; confirmation of membership in a related clan; showing loyalty within the official hierarchy, investing in a career. Despite the legislative restrictions on the scale of weddings adopted in Uzbekistan and Tajikistan no impressive results have been achieved. The discrepancy between social expectations threaten to turn into reputational losses. People continue to pay tribute to the requirements of the ritual economy, going to all sorts of tricks in order not to fall under the sanctions of the state
Russia's Forest Sector After The Years of Reforms: More Laws, but Less Order?
Authors:   Siberian Federal University, Pyzhev Anton I.
Published: October 2022

The article discusses the impact of the growing intensity of normative activity in the forestry complex of Russia on the efficiency of the industry. Estimates show that over the last decade and a half, various ministries and departments have adopted at least 400 normative documents regulating various spheres of forest relations. Meanwhile, even without analyzing the statistics, it is clear that such a vigorous normative activity hardly leads to prosperity of the national forestry complex, and certainly does little to help solve the most important problems of forestry, which is especially evident against the background of steadily growing from year to year forest fires and the accompanying damage. We propose a way to reconstruct a long time series volume of logging from official statistics on the export of wood, which was available before 2009. By the example of Siberian regions according to the data for 2005–2020 year regression models panel data are built, providing evidence in favor of the fact that the intensity of rule-making has a negative impact on the amount of timber harvest. It is proposed to fundamentally revise the approaches to the regulation of the forest industry, abandoning the adoption of redundant regulations in favor of government complicity in solving the problems of Russian forests, which have accumulated for many decades.
The Utilities of Online Formative Assessment in Indonesian EFL Learning Contexts during Covid-19 Era
Authors: Wijaya Kristian Florensio
Published: October 2022

Amid COVID-19 pandemic, online formative assessment has grown in English Language Teaching. Previous researchers strongly contended that the accurate usage of online formative assessment could remarkably substantiate EFL learners’ target language learning motivation, achievements, and outcomes. This present qualitative study was conducted in support of a document analysis approach to generate varied insightful perspectives for Indonesian EFL teachers and learners to begin valuing the potential rewarding merits as a result of online formative assessment implementations in distant learning situations. Twenty relevant online formative assessment studies from 2020 until 2022 year were selectively chosen to produce more up-to-date and rewarding research findings worth applicable in nowadays Indonesian EFL teaching-learning enterprises. Based on the in-depth document analysis, two major pivotal research results strongly encouraged Indonesian EFL teachers to make use of online formative assessment in daily-based online learning activities namely: (1) online formative assessment progressively promotes holistic second language learning rewards for learners and (2) online formative assessment fully creates a more convenient EFL teaching-learning atmosphere for learners. These above-depicted research results opened a broader perspective for future researchers to replicate this research theme in the light of potential online formative assessment shortcomings and a greater number of relevant investigation sources.