bluuebunny/crossref_metadata_2025 huggingface dataset:
Examining Impacts of COVID-19-Related Stay-At-Home Orders through a Two-Way Random Effects Model
Authors: Bamney Anshu , Jashami Hisham , Sonduru Pantangi Sarvani , Ambabo Jayson , Megat-Johari Megat-Usamah , Cai Qiuqi , Gupta Nischal , Savolainen Peter T.
Published: September 2021

The COVID-19 pandemic has had far-reaching impacts on public health and safety, economics, and the transportation system. To reduce the spread of this disease, federal and local governments around the world have introduced stay-at-home orders and other restrictions on travel to “non-essential” businesses to implement social distancing. Preliminary evidence suggests substantial variability in the impacts of these orders in the United States, both across states and over time. This study examines this issue using daily county-level vehicle miles traveled (VMT) data for the 48 continental U.S. states and the District of Columbia. A two-way random effects model is estimated to assess changes in VMT from March 1 to June 30, 2020 as compared with baseline January travel levels. The implementation of stay-at-home orders was associated with a 56.4 percent reduction in VMT on average. However, this effect was shown to dissipate over time, which may be attributable to “quarantine fatigue.” In the absence of full shelter-in-place orders, travel was also reduced where restrictions on select businesses were introduced. For example, restrictions on entertainment, indoor dining, and indoor recreational activities corresponded to reductions in VMT of 3 to 4 percent while restrictions on retail and personal care facilities showed 13 percent lower traffic levels. VMT was also shown to vary based on the number of COVID case reports, as well as with respect to other characteristics, including median household income, political leanings, and how rural the county was in nature.
Can Open Science be a Tool to Dismantle Claims of Hardwired Brain Sex Differences? Opportunities and Challenges for Feminist Researchers
Authors: Persson Sofia , Pownall Madeleine
Published: September 2021

Feminist scholars have long been concerned with claims of hardwired brain sex differences emanating from neuroscience and evolutionary psychology. Past criticisms of these claims have rightfully questioned the impact of this research on gender equality, pointing out how findings can be used to vindicate gender stereotypes. In this article, we appraise the brain sex differences literature through the lens of open science, a movement aimed at improving the robustness and reliability of science. In this discussion, we offer a feminist evaluation of the strategies (e.g., pre-registration, data sharing, and accountability) provided by open science, and we question whether these may be the novel and disruptive tools needed to dismantle claims about hardwired brain sex differences. We suggest that open science strategies can be useful in challenging some of these claims, and we note that promising initiatives are already being developed in neuroscience and allied fields. We end by acknowledging the distinct challenges that feminist researchers wishing to engage in open science face, particularly in the context of limited diversity. We conclude that open science presents considerable opportunity for feminist researchers, and that it will be crucial for feminists to be involved in shaping the future of this movement.
Psychological Functioning Among Latino Victims of Teen Dating Violence: The Role of Relational and Collective Resources
Authors: Sabina Chiara , Marsical E. Susana , Cuevas Carlos A.
Published: September 2021

This study examined whether the relationship between teen dating violence (DV) and psychological functioning (depression, anxiety, and hostility) varied as a function of relational and collective resources (social support, familism, and school connectedness) among Latino teen victims of DV. Data came from a subset of youth who experienced DV ( n = 95) from the Dating Violence Among Latinos Adolescents Study, a national survey of Latino teens aged 12-18 years old. Multivariate regression models showed that school connectedness was associated with lower depression and anxiety for DV victims. Additionally, five interactions were significant across depression, anxiety, and hostility: Three following a pattern of protective-enhancing (DV × School connectedness for depression and anxiety; DV × Social support for anxiety) and two following a pattern of vulnerability-reactive (DV × Familism for anxiety and hostility). School connectedness is an important protective factor for Latino teen victims of DV and one that can inform intervention efforts. Latino victims of DV benefit from high levels of school connectedness and social support, especially when DV is high. At high levels of DV familism is associated with a worsening of mental health. It is important to understand the nuances of how these resources work at varying levels of DV for intervention and prevention purposes.
Mesenchymal Stem Cell-Induced Anti-Neuroinflammation Against Traumatic Brain Injury
Authors: Cozene Blaise , Sadanandan Nadia , Farooq Jeffrey , Kingsbury Chase , Park You Jeong , Wang Zhen-Jie , Moscatello Alexa , Saft Madeline , Cho Justin , Gonzales-Portillo Bella , Borlongan Cesar V
Published: September 2021

Traumatic brain injury (TBI) is a pervasive and damaging form of acquired brain injury (ABI). Acute, subacute, and chronic cell death processes, as a result of TBI, contribute to the disease progression and exacerbate outcomes. Extended neuroinflammation can worsen secondary degradation of brain function and structure. Mesenchymal stem cell transplantation has surfaced as a viable approach as a TBI therapeutic due to its immunomodulatory and regenerative features. This article examines the role of inflammation and cell death in ABI as well as the effectiveness of bone marrow-derived mesenchymal stem/stromal cell (BM-MSC) transplants as a treatment for TBI. Furthermore, we analyze new studies featuring transplanted BM-MSCs as a neurorestorative and anti-inflammatory therapy for TBI patients. Although clinical trials support BM-MSC transplants as a viable TBI treatment due to their promising regenerative characteristics, further investigation is imperative to uncover innovative brain repair pathways associated with cell-based therapy as stand-alone or as combination treatments.
Entrepreneurs’ Ethnic and Political Identity Alignment as Determinants of Access to Government Support in Africa: A Conceptual Framework
Authors: Abebe Michael A. , Getachew Yamlaksira S. , Kimakwa Sarah
Published: September 2021

This article contributes to research on the role of government in entrepreneurship by extending the current focus from government policies to policymakers. Specifically, we examine how entrepreneurs’ identity alignment with regime leaders influences their access to government support in Africa. Drawing from ethnocentrism and neopatrimonialism perspectives, we develop a theoretical model that explains how entrepreneurs’ ethnic and political identity alignment influences their access to government support. We also advance theory by discussing the “dark side” of identity-based government support in Africa. In doing so, we shed some light on the rather complex sociopolitical determinants of resource access in Africa.
Development and Implementation of an Integrated Academic-Behavior Intervention
Authors: Gettinger Maribeth , Kratochwill Thomas R. , Foy Alison , Eubanks Abigail
Published: September 2021

The relationship between learning disabilities and behavior disorders is well documented and has led to the development of integrated interventions that target both academic and behavior deficits in elementary school–age students. This paper describes the rationale for, development of and implementation of an integrated academic-behavior intervention called a cademic and behavior combined support ( ABC Support). The intervention was developed by integrating the critical intervention elements from two single-focus interventions (i.e., repeated reading and check-in/check-out) into a single comprehensive intervention designed to improve reading fluency for early elementary school–age students with reading disorders while also strengthening their engagement and compliance with behavior expectations.
Endoscopic Flexor Hallucis Longus Transfer for the Management of Acute Achilles Tendon Ruptures in Professional Soccer Players
Authors: Abdelatif Nasef Mohamed N. , Batista Jorge Pablo
Published: September 2021

Background:

Acute Achilles tendon ruptures (AATRs) that occur in athletes can be a career-ending injury. The aim of this study was to describe return to play and clinical outcomes of isolated endoscopic flexor hallucis longus (FHL) transfer in active soccer players with AATR.

Methods:

Twenty-seven active male soccer players who underwent endoscopically assisted FHL tendon transfer for acute Achilles tendon ruptures were included in this study. Follow up was 46.2 (±10.9) months after surgery. Return to play criteria and clinical outcome measures were evaluated.

Results:

All players returned to playing professional competitive soccer games. Return to active team training was at a mean of 5.8 (±1.1) months postoperatively. However, return to active competitive match play occurred at a mean of 8.3 (±1.4) months. Twenty-two players (82%) were able to return to their preinjury levels and performances and resumed their professional careers at the same soccer club as their preinjury state. One player (3.7%) shifted his career to professional indoor soccer. At 26 months postoperatively, the mean Tegner activity scale score was 9.7 (±0.4), the mean Achilles tendon total rupture score was 99 (±2), and the mean American Orthopaedic Foot & Ankle Society ankle-hindfoot score was 99 (±3). No patients reported any great toe complaints or symptomatic deficits of flexion strength.

Conclusion:

The current study demonstrated satisfactory and comparable return to play criteria and clinical results with minimal complications when using an advanced endoscopically assisted technique involving FHL tendon transfer to treat acute Achilles tendon ruptures in this specific subset of patient cohort.

Level of Evidence:

Level II, prospective cohort case series study.
Evaluating Initial Empiric Therapy for Neutropenic Fever in Vancomycin-Resistant Enterococcus-Colonized Patients
Authors: Snyder Matthew , Pasikhova Yanina , Baluch Aliyah
Published: September 2021

Objectives

Vancomycin-resistant enterococcus infections impact mortality in oncology patients. Given the low rate of vancomycin-resistant enterococcus bacteremia, low virulence of vancomycin-resistant enterococcus, and advent of rapid diagnostic systems, vancomycin-resistant enterococcus-directed empiric therapy in vancomycin-resistant enterococcus-colonized patients with neutropenic fever may be unnecessary, promoting increased antimicrobial resistance, drug-related toxicity, and cost.

Methods

Vancomycin-resistant enterococcus-colonized adults admitted for hematopoietic stem cell transplantation or induction therapy for acute leukemia/myeloid sarcoma with neutropenic fever were stratified by vancomycin-resistant enterococcus bacteremia development and empiric vancomycin-resistant enterococcus-directed antimicrobial strategy for first neutropenic fever (Empiric Therapy vs. non-Empiric Therapy). Primary endpoints included vancomycin-resistant enterococcus-related, in-hospital, and 100-day mortality rates. Secondary outcomes included vancomycin-resistant enterococcus bacteremia incidence for first neutropenic fever and the entire hospitalization, length of stay, Clostridioides difficile infection rate, and duration and cost of vancomycin-resistant enterococcus-directed therapy.

Results

During first neutropenic fever, 3 of 70 eligible patients (4%) developed vancomycin-resistant enterococcus bacteremia. Although all 3 (100%) were non-Empiric Therapy, no mortality (0%) occurred. Of 67 patients not developing vancomycin-resistant enterococcus bacteremia, 42 (63%) received Empiric Therapy and 25 (37%) non-Empiric Therapy. Empiric Therapy had significantly greater median duration (3 days vs. 0 days; P<.001) and cost ($1604 vs. $0; P<.001) of vancomycin-resistant enterococcus-directed therapy but demonstrated no significant differences in clinical outcomes.

Conclusion

Available data suggest Empiric Therapy may offer no clinical benefit to this population, regardless of whether vancomycin-resistant enterococcus is identified in blood culture or no pathogen is found. Such an approach may only expose the majority of patients to unnecessary vancomycin-resistant enterococcus-directed therapy and drug-related toxicities while increasing institutional drug and monitoring costs. Even in the few patients developing vancomycin-resistant enterococcus bacteremia, waiting until the organism is identified in culture to start directed therapy likely makes no difference in mortality. This lack of benefit warrants consideration to potentially omit empiric vancomycin-resistant enterococcus-directed therapy in first neutropenic fever in many of these patients.
Factors Influencing the Selection of Non-Vitamin K Antagonist Oral Anticoagulants for Stroke Prevention in Patients With Non-Valvular Atrial Fibrillation
Authors: Park Susin , Je Nam Kyung
Published: September 2021

Background:

Major atrial fibrillation (AF) guidelines recommend non-vitamin K antagonist oral anticoagulants (NOACs) over warfarin, except in rare clinical circumstances based on 4 randomized controlled trials comparing each NOAC with warfarin. We aimed to investigate the current NOAC prescription behaviors in alignment with the recent clinical evidence available.

Method:

We conducted a cross-sectional analysis of NOAC-using patients with non-valvular atrial fibrillation (NVAF) who were aged ≥65 years on the index date (July 1, 2018) based on nationwide claims data. The types of NOACs being taken were analyzed using chi-squared tests, and factors influencing NOAC selection were identified using multinomial logistic regression analysis.

Results:

A total of 6,061 patients were included. Among the 4 NOACs, rivaroxaban was the most used NOAC. Patients aged ≥75 years (odds ratio [OR] = 1.270, confidence interval [CI] = 1.089-1.450) and women (OR = 1.148, CI = 1.011-1.284) were more likely to use apixaban relative to rivaroxaban. Patients with prior stroke/transient ischemic attack/thromboembolism had higher odds of using dabigatran (OR = 1.508, CI = 1.312-1.704) and apixaban (OR = 1.186, CI = 1.026-1.346). Patients with renal disease had higher odds of using apixaban (OR = 1.466, 95% CI = 1.238-1.693). These findings are consistent with the efficacy and safety profiles reported in pivotal trials and observational studies comparing individual NOACs.

Conclusion:

Among the 4 NOACs, rivaroxaban was the most commonly used NOAC. Apixaban was preferred for patients aged ≥75 years, females, and patients with renal disease.
Sexual and Relationship Violence Prevention Programming on Commuter Campuses: Wisdom From Students and Campus Personnel
Authors: Casey Erin A. , Hampson Sarah C.
Published: September 2021

Responding to the dearth of literature regarding sexual and relationship violence prevention programming on nonresidential university campuses, this study investigates how students and staff conceptualize prevention on commuter campuses. We use qualitative analysis of data from interviews with personnel, and focus groups with students on three commuter campuses and describe (a) the unique considerations associated with implementing prevention in commuter contexts and (b) core elements of comprehensive prevention approaches on these campuses. Results suggest that comprehensive prevention programming is desired by commuter campus stakeholders, but requires policy revision, creative delivery strategies, and student involvement, among other factors, to be realized.
Bruton tyrosine kinase inhibitors for Waldenström macroglobulinemia: A review
Authors: Moore Donald C
Published: September 2021

Objective

The objective of this review is to evaluate the available evidence for the Bruton tyrosine kinase inhibitors in the treatment of Waldenström macroglobulinemia.

Data sources

A search of the PubMed database was conducted using the following search terms: ibrutinib, PCI-32765, acalabrutinib, ACP-196, zanubrutinib, BGB-3111, and Waldenström macroglobulinemia. Prospective clinical trials evaluating the efficacy and safety of ibrutinib, acalabrutinib, and zanubrutinib in patients with Waldenström macroglobulinemia were evaluated. Abstracts from the American Society of Hematology and American Society of Clinical Oncology annual meetings were reviewed as well as the prescribing information for each drug.

Data summary

The first-generation Bruton tyrosine kinase inhibitor ibrutinib received Food and Drug Administration approval for Waldenström macroglobulinemia in 2015; this was the first drug approved for this rare condition. Ibrutinib has been evaluated as monotherapy and in combination with rituximab for the treatment of Waldenström macroglobulinemia. Since then, second-generation Bruton tyrosine kinase inhibitors, acalabrutinib and zanubrutinib, have been evaluated in prospective clinical trials for the treatment of Waldenström macroglobulinemia. All three agents have demonstrated high overall response rates and durable responses.

Conclusion

Bruton tyrosine kinase inhibitors have demonstrated significant clinical activity in the treatment of Waldenström macroglobulinemia, both in treatment naïve as well as the relapsed/refractory patient populations.
Differences in Mortality Rates of Gunshot Victims: The Influence of Neighborhood Social Processes
Authors: Magee Lauren A.
Published: September 2021

Firearm violence is considered a public health crisis in the United States. Firearm violence spatially concentrates within neighborhoods and is associated with community factors; however, little is understood about the geographic differences in gunshot wound mortality and associated neighborhood social processes. Applying a public health approach through the Haddon’s Matrix, the results demonstrate systematic differences in social and physical features associated with gunshot mortality. These findings have important implications to improve neighborhood physical and social conditions, police transporting gunshot victims, and police-public health partnerships to improve data collection on nonfatal shootings and shots fired.
Vancomycin and daptomycin stability in heparin or sodium citrate lock solutions
Authors: Bodega-Azuara Julia , Bellés-Medall Maria Dolores , Edo-Peñarrocha Josep , Ferrando-Piqueres Raúl , Perez-Alba Alejandro , Reque-Santivañez Javier
Published: September 2021

Background:

We investigated physical and chemical stability of daptomycin and vancomycin in heparin or sodium citrate lock solutions. The aim of this study was to find the optimal combination of antimicrobials and additives for lock solutions, which maximized patient safety.

Methods:

Vancomycin and daptomycin were diluted with heparin or sodium citrate to achieve final concentrations of vancomycin-heparin 2.5 mg/mL–833.33 U/mL, vancomycin-citrate 2.5–33.3 mg/mL, daptomycin-heparin 5 mg/mL–800 U/mL, and daptomycin-citrate 5–32 mg/mL and they were stored at room temperature (+25°C), 4°C, −20°C, and 37°C. Physical and chemical stability were analyzed for each antibiotic-anticoagulant combination in all conditions immediately after preparation, at 24, 48, 72 h and at different time points until unstable concentrations were obtained. Daptomycin-sodium citrate microbiological activity was also studied by evaluating two Staphylococcus aureus cultures in a calcium enriched medium with a daptomycin E test, with and without sodium citrate.

Results:

After incubation at 37°C vancomycin and daptomycin combined with heparin retained at least 90% of the initial concentration over 48 h. Vancomycin-sodium citrate solution stored at 37°C reduced more than 10% of the initial concentration at 24 h. On the other hand, daptomycin-sodium citrate preparation was stable at 37°C for 72 h but the microbiological activity of daptomycin was lower in the presence of sodium citrate.

Conclusions:

The purpose is to prepare vancomycin and daptomycin lock solutions combined with heparin. They should be changed at 48 h and its stability is over 3 days at 25°C and 7 days at 4°C, which allow Hospital Pharmacy Services to manage their stocks. Daptomycin-sodium citrate combination is more stable for extended periods but its bioactivity has not been demonstrated.
The virtuous cycle: the reinforcing relationship between L2 attitudes and L2 use among young Italian-speaking South-Tyrolese
Authors: Marton Enikő , Kovács Magdolna , Vincze László
Published: September 2021

Aims and Objectives:

The aim of the present study is to address the reciprocal relationship between L2 attitudes and L2 use in a bilingual setting among teenaged L2 learners. Whereas several scholars suggested that L2 attitudes and L2 use mutually facilitate each other, empirical studies have traditionally assessed the relationship between L2 attitudes and L2 use from one direction. Design/Methodology: We propose a complex model that integrates concepts tied to the larger social context surrounding formal L2 teaching, such as attitudes towards L2 speakers and L2 use outside the school, with concepts that are more closely associated with formal L2 teaching, such as L2 motivation and L2 competence. In addition, acknowledging that peers’ opinion is a salient issue for teenagers, we also included L2 related peer norms into the model we propose. Based on earlier research we developed six hypotheses regarding the relationships between the theoretical concepts. Self-report questionnaire data were collected among students in Italian language secondary schools in South Tyrol ( N = 315). The questionnaire included items from well-established and validated measurement instruments. We tested the proposed model with non-recursive path modelling.

Findings/Conclusions:

All the hypotheses were substantiated by the data. We found that both L2 attitudes and L2 related peer norms predicted L2 motivation. In addition, a significant interaction emerged between L2 attitudes and peer norms. L2 motivation predicted L2 competence which in turn predicted L2 use. Finally, the results have provided evidence of a reinforcement process, namely, that L2 use can contribute to positive intergroup attitudes.

Originality:

To the best of our knowledge, the present paper is the first that utilized non-recursive path modelling in exploring patterns of bilingualism. Significance/Implications: In bilingual settings, L2 use can promote better L2 attitudes. Positive peer norms regarding L2 can counterbalance the effect of negative attitudes on second language acquisition.
Serviceability performance of fiber-reinforced lightweight aggregate concrete beams with CFRP bars
Authors: Sun Yijia , Wu Tao , Liu Xi
Published: September 2021

Six lightweight aggregate concrete (LWC) beams reinforced with carbon fiber–reinforced polymer (CFRP) bars were tested under a four-point bending load with different steel fiber contents, reinforcement ratios, and clear span lengths to investigate their flexural behavior and serviceability performance. The test results showed that using steel fiber–reinforced lightweight aggregate concrete (SFLWC) and increasing the reinforcement ratio enhanced the serviceability performance of the beams. The incorporation of 0.6% by volume of steel fibers reduced the midspan deflection by 22.70%–36.87% at the same load level in service stage. At service load, all the CFRP-reinforced beams exhibited conservative deflections when compared to the deflection limits recommended by ACI 440.1 R and GB 50608, and satisfied the crack width limit of 0.7 mm. Comparing the measured maximum crack widths with the corresponding predictions revealed that the bond-dependent coefficient value of 1.4 specified in ACI 440.1 R was reasonable yet conservative. Moreover, an energy-based method was adopted to quantify the influence of the fibers on the beam stiffness. On this basis, a rational deflection model for SFLWC beams reinforced with CFRP bars was suggested.
Effect of delayed resonator on the vibration reduction performance of vehicle active seat suspension
Authors: Zhang Yongguo , Ren Chuanbo , Ma Kehui , Xu Zhen , Zhou Pengcheng , Chen Yajie
Published: September 2021

The combination of dynamic vibration absorber and partial state feedback with time-delay is called delayed resonator. In order to suppress the seat vibration caused by uneven road surface and improve ride comfort, the delayed resonator is applied to the seat suspension to realize active control of the seat suspension system. The dynamic model of the half-vehicle suspension system is established, and the time-delay differential equation of the system under external excitation is solved by the precise integration method. The root mean square of the time-domain vibration response of seat displacement, seat acceleration and vehicle acceleration are selected as the objective function. Then, the optimal time-delay control parameters are obtained by particle swarm optimization algorithm. The frequency sweeping method is used to obtain the critical time-delay value and time-delay stable interval of the system. Finally, an active seat suspension model with delayed resonator is established for numerical simulation. The results show that the delayed resonator can greatly suppress the seat vibration response regardless of the road simple harmonic excitation or random excitation. Compared with dynamic vibration absorber, it has a better vibration absorption effect and a wider vibration reduction frequency band.
Datafication research: Mapping the field for a future agenda
Authors: Flensburg Sofie , Lomborg Stine
Published: September 2021

A growing body of research centers around the concept of “datafication” suggesting a buzz around data studies and, perhaps, the emergence of a research field. This article analyzes and discusses the current state of datafication research. Our dataset comprises 463 publications on datafication identified through a systematic literature search in Web of Science and Scopus, an explorative network analysis of keyword co-occurrences and a content analysis of these publications. We map datafication research interests in various research fields, find that the majority of studies are theoretically oriented, whereas empirical analyses largely apply qualitative approaches and rarely make use of data-driven methods. We suggest studies on datafication can be devised into categories reflecting research interests in either user understandings and practices or in infrastructure and technological processes of datafication. The latter strand is particularly sparse in empirical anchoring, and needs empirical and methodological attention. We conclude by outlining three paths for future datafication research to cross-pollinate infrastructural and user perspectives, highlighting the bridging role of communication research in such an endeavor.
Coloniality, just war & carceral injustice in Brazil
Authors: Darke Sacha , Khan Omar Phoenix
Published: September 2021

The Portuguese empire brought inescapable violence to the indigenous communities of Brazil and to those it enslaved. Throughout the centuries of colonial subjugation, driven by the Iberian monarchical traditions of hierarchy, militarism and moral crusade, ‘just war’ narratives were employed to legitimate the use of violent legal and extra-legal measures against enslaved peoples and others deemed unruly or rebellious and a threat to colonial order. Two centuries after independence, Brazil remains at war with its ‘internal enemies’. Its justice practices continue to be characterised by colonial rationalisations. This paper illustrates the contemporary coloniality inherent in the carceral system from the moment of detention pre-trial through sentencing and imprisonment.
A Theory of Justice Fifty Years Later
Authors: Gališanka Andrius
Published: September 2021

John Rawls's A Theory of Justice has reshaped liberal political theory, but what fruitful arguments does it generate today, fifty years after its publication? To show Theory's productive contemporary lives, I outline its key concepts and commitments, focusing on Rawls’ goal to uncover a consensus among reasonable persons. I highlight arguments in global justice and animal rights in which Theory's concept of the basic structure was fruitfully employed. Moreover, I argue that Rawls envisioned consensus as agreement only on very broad terms. Perhaps more than he realized, he left it to citizens to deal with everyday questions about justice, in which identities and power are central. I suggest that to extend Theory to such questions, theorists can combine its central values, such as those of self-respect and autonomy, with independent conceptions of power, so long as these treat arguments as irreducible to power relations.
Video Game Development in India: A Cultural and Creative Industry Embracing Regional Cultural Heritage(s)
Authors: Zeiler Xenia , Mukherjee Souvik
Published: September 2021

Game development and production practices are complex and highly reflected processes—worldwide. This explorative article discusses video game development as a cultural and creative industry in India, including the industry’s history and introducing recent trends which indicate profound transformations—the use and implementation of Indian cultural heritage in game settings. In the rather short history of Indian game development as compared to other countries—a significant number of games made in India first were produced around 2010—the industry has already lived through big changes and challenges. This article aims at introducing Indian game development and argues that especially independent (so-called indie) game studios in their search for their own, region-specific game development and stand-alone characteristics for Indian games increasingly turn to what they perceive as their own cultural heritage, including, for example, elements from history, art (music, dance, dress styles, and others), and architecture.
Public Awareness of a Plant-Based Diet Following the Release of “Game Changers” and “What The Health” Documentaries
Authors: Hartwell Micah , Torgerson Trevor , Essex Ryan , Campbell Ben , Belardo Danielle , Vassar Matt
Published: September 2021

Background: Poor diet is a leading cause of premature death and thus diet and lifestyle changes are needed; yet, no consensus exists regarding diets that provide the greatest benefit. One of these diets gaining popularity around the world is a plant-based, vegan diet. Recently, Netflix documentaries What the Health (2017) and The Game Changers (2019) have attempted to improve public awareness of veganism and plant-based diets. Methods: We used Google Trends to obtain data for keywords specific to plant-based diets, veganism, and documentary-specific terms over a time period before and after the release of the Netflix documentaries. We then created a forecasted model for trended search terms using autoregressive integrated moving algorithms and compared the actual trends to the forecast model to determine the effect of the documentaries on each selected term. Results: Search interest for the term “plant-based diet” increased significantly—2.8 times the mean forecasted value for What the Health ( t = 12.892, df = 30.012, P < .001) and 2 times the forecasted mean for The Game Changers ( t = 19.826, df = 30.118, P < .001). Additionally, following the release of The Game Changers, mean search interest for “plant-based athlete” was 2.8 times higher than the forecasted values. Conclusion: The documentaries What the Health (2017) and The Game Changers (2019) are associated with an increased interest in plant-based diets based on Google search trends, highlighting the need for continued research regarding plant-based diets and their health benefits related to chronic disease.
Development of a new type of automatic magnetic particle inspection wall-climbing robot
Authors: Liu Jun , Yu Hanlin , Mei Linbo , Han Bo
Published: September 2021

In the paper, a permanent magnet adsorption wall-climbing robot using magnetic particle detection technology for crack detection is introduced, which solves the problems of low efficiency of traditional manual detection and long detection time. According to the working environment of the detection system and the detection functions that need to be completed, the body structure of the robot is designed, the overall size of the robot is smaller than the distance between two steam turbine blades, so it can achieve the crack detection function of large steam turbine blades, and the stability and force analysis of the robot are carried out, and the adsorption conditions that meet the conditions of no sliding and overturning are obtained. In the paper, we use the magnetic circuit method to design a miniature excitation device for robotic applications and use the simulation software Ansoft-Maxwell to verify its feasibility. In the final experiment, it can be shown that the robot designed can achieve a series of functions such as magnetic particle inspection and image acquisition. There is a good prospect for the inspection of turbine blades.
Lived Experience of Hereditary Chronic Pancreatitis – A Qualitative Interview Study
Authors: Müller Regina , Aghdassi Ali A , Kruse Judith , Lerch Markus M , Rach Christoph , Simon Peter , Salloch Sabine
Published: September 2021

Objectives

Hereditary chronic pancreatitis is a rare condition characterized by intermittent acute episodes of pancreatitis and long-term impairment of pancreatic functions. However, the subjective perspective of individuals affected by hereditary chronic pancreatitis has been little studied. This qualitative study investigates the experience of hereditary chronic pancreatitis patients and their relatives because the awareness of the needs of those affected is an essential component of a patient-centered management of chronic conditions.

Methods

Semi-structured qualitative interviews were conducted with hereditary chronic pancreatitis patients and their relatives. Data were analysed using qualitative content analysis. The concepts of ‘biographical contingency,’ ‘biographical disruption’ and the ‘shifting perspectives model’ served as theoretical frameworks.

Results

A total of 24 participants (17 patients, 7 relatives) were interviewed individually. Four main themes were identified: (1) The unpredictable clinical course of hereditary chronic pancreatitis; (2) hereditary chronic pancreatitis as a devastating experience; (3) hereditary chronic pancreatitis as part of a normal life; and (4) being reduced to hereditary chronic pancreatitis.

Discussion

The ‘shifting perspectives model’ of chronic illness covers the four dimensions adequately and can serve as a theoretical model to explain hereditary chronic pancreatitis patients’ experience. A better understanding of the patients and their families’ experience and the shifting character of hereditary chronic pancreatitis can help healthcare professionals to tailor the care to meet the needs of those affected.
A prospective multicentre observational study to quantify nocturnal light exposure in intensive care
Authors: Craig Thomas , Mathieu Steve , Morden Clare , Patel Mitul , Matthews Lewis
Published: September 2021

Background

Disrupted circadian rhythms can have a major effect on human physiology and healthcare outcomes, with proven increases in ICU morbidity, mortality and length of stay.

Methods

We performed a multicentre observational study to study the nocturnal lux exposure of patients in 3 intensive care units.

Results

The median light intensity recorded was 1 lux over the 6-hour recording period; however, this is deceptive as it hides short periods of high lux. When looked at in shorter time segments of 30 minutes, there were significant periods of lux higher than a crude median, especially in higher acuity patients. There was a positive correlation between acuity (as estimated by SOFA score) and maximum lux (R = 0.479, p = .0001), median lux (R = 0.35, p = .006) and cumulative lux (R = 0.55, p = .000001). There was no relationship between neighbouring patient acuity and lux.

Conclusions

Clinicians should practice vigilance at night to provide optimal environmental conditions for patients to minimise potential harm.
Key elements of an evidence-based clinical psychology service within adult critical care
Authors: Beadman Matthew , Carraretto Mike
Published: September 2021

The COVID-19 pandemic has generated renewed interest in the psychological rehabilitation needs of patients admitted to intensive care units. While the availability of embedded practitioner psychologists within adult critical care teams remains inconsistent, post numbers have increased in response to the clinical needs of the pandemic. As psychology services within adult critical care become more widely established, models for service provision will be required. We describe our experience of developing a model for the delivery of a clinical psychology service within critical care in a District General Hospital with specialist tertiary surgical and cancer services. The current paper describes a service design that is firmly rooted in psychological theory and the broader clinical health psychology evidence base. We hope that our learning will be helpful to others.
Less Exposure for Health Care Workers, More Comfort for Patients During COVID-19 Swab Testing
Authors: Karaca Adeviyye , Akçimen Mehmet , Özen Hatice
Published: September 2021

Background

Nasopharyngeal (NP) and oropharyngeal (OP) swab sampling for coronavirus disease 2019 (COVID-19) diagnosis may lead to release of particles of varying sizes and increase the exposure risk for health care workers (HCWs). However, there is limited evidence for effective methods to reduce occupational exposure from NP and OP swab sampling. This study aimed to reduce droplet-forming responses (DFRs) and the related exposure risk of NP and OP swab sampling by administering 10% lidocaine spray (LS) to the NP and OP areas prior to conducting swab tests.

Methods

This quasi-experimental study was conducted with 100 patients who presented to our tertiary care hospital with symptoms of COVID-19 between December 1 and 15, 2020. First, NP and OP swabbings were performed on each patient. Thereafter, LS was applied to the OP and NP regions, and the swab samples were taken once again. Frequency of DFRs and real-time polymerase chain reaction (RT-PCR) test results before and after LS application were recorded for comparison. In addition, the cycle threshold (Ct) was used as a proxy indicator for SARS-CoV-2 viral load in COVID-19 positive cases.

Findings

Significant differences in OP DFR frequencies before and after LS intervention were found (37% and 9%, respectively), as well as before and after NP DFR (31% and 18%, respectively). The mean Ct values for the positive samples did not differ before and after applying LS.

Conclusion

Our results suggest that applying LS to the OP and NP area prior to swab testing reduces DFR frequencies without affecting (RT-PCR) test results for SARS-CoV-2 and may increase patient and practitioner comfort.
Prospective and Randomized Clinical Evaluation of Hamstring Versus Patellar Tendon Autograft for Anterior Cruciate Ligament Reconstruction in Soccer Players
Authors: Guglielmetti Luiz Gabriel Betoni , Salas Victor Eduardo Roman , Jorge Pedro Baches , Severino Fabrício Roberto , Duarte Aires , de Oliveira Victor Marques , Cury Ricardo de Paula Leite
Published: September 2021

Background:

Anterior cruciate ligament (ACL) reconstruction is usually performed with autologous bone–patellar tendon–bone (PT) or hamstring tendon (HT) graft. There has been only 1 randomized clinical trial examining ACL reconstruction with these grafts specifically in soccer players, and more studies comparing these graft types within a homogenous cohort such as soccer athletes may better highlight differences in outcomes.

Purpose:

To compare the results of ACL reconstruction with PT versus HT autograft in soccer players and to evaluate objective and subjective outcomes.

Study Design:

Randomized controlled trial; Level of evidence, 1.

Methods:

A total of 62 professional or semiprofessional soccer players (mean age, 25.1 years) with ACL injury were randomized to undergo reconstruction with PT or HT autograft by a single orthopaedic surgeon (n = 31 in each group). Outcome measures were recorded preoperatively and at 2 years postoperatively. The primary outcome was the modified Cincinnati Knee Rating System, and secondary outcomes were the objective and subjective International Knee Documentation Committee scores, Lachman test, pivot-shift test, anterior drawer test, and Lysholm score. The following variables were also evaluated postoperatively: return to soccer, level at return, graft rerupture, postoperative complications, anterior knee pain, patellar tendinitis, difficulty sprinting, and loss of kicking power.

Results:

The PT and HT groups were homogenous in terms of age, sex distribution, injured side, and time from injury to surgery, and there was no difference between them on any preoperative outcome score. At 2 years postoperatively, there were no differences between the groups on any outcome score; however, there were significantly fewer patients with anterior knee pain in the HT group compared with the PT group (7 [22.6%] vs 15 [48.4%], respectively; P = .03). Two patients from each group (2/31; 6.5%) sustained rerupture.

Conclusion:

There were no differences between soccer players who underwent different types of ACL reconstruction with the exception of anterior knee pain, which was more frequent in players who underwent reconstruction with PT graft. Registration: NCT02642692 ( ClinicalTrials.gov ).
Prior Bone Marrow Stimulation Surgery Influences Outcomes After Cell-Based Cartilage Restoration: A Systematic Review and Meta-analysis
Authors: Cogan Charles J. , Friedman James , You Jae , Zhang Alan L. , Feeley Brian T. , Ma C. Benjamin , Lansdown Drew A.
Published: September 2021

Background:

Cell-based cartilage restoration with autologous chondrocyte implantation (ACI) is a safe and effective treatment for symptomatic cartilage lesions. Many patients undergoing ACI have a history of prior surgery, including bone marrow stimulation (BMS). There is mounting evidence that a history of prior BMS may impede healing of the ACI graft.

Purpose/Hypothesis:

The purpose of this study was to compare the failure rates of primary ACI with ACI after prior BMS. We hypothesized that ACI after BMS would have a significantly higher failure rate (defined as reoperation, conversion to arthroplasty, and/or imaging-based failure) compared with primary ACI.

Study Design:

Systematic review; Level of evidence, 4.

Methods:

A literature search was performed by use of PubMed and Embase databases for relevant articles published through October 2, 2020, to identify studies evaluating outcomes and failures rates of ACI after prior BMS in the knee.

Results:

Included were 11 studies comprising 1479 ACI procedures. The mean age at surgery ranged from 18.3 to 39.1 years, and the mean follow-up ranged from 3 to 20.6 years. All studies reported failure rates. The overall failure rate was significantly higher in the patients who underwent ACI after BMS, at 26.4% compared with 14.8% in the ACI group ( P < .001). Meta-analysis demonstrated an increased risk of failure in patients with a history of prior BMS (log odds ratio = –0.90 [95% confidence interval, –1.38 to –0.42]).

Conclusion:

This systematic review demonstrated that failure rates were significantly higher for patients treated with ACI after BMS relative to patients undergoing ACI without prior BMS. This finding has important implications when considering the use of BMS for defects that are amenable to cell-based restoration and when determining treatment options after failed BMS.

Registration:

PROSPERO (CRD42020180387).
Application of a Simulation-Based Interprofessional Teamwork Assessment Tool (SITAT) to Individual Student Performance in a Team-Based Simulation
Authors: Daulton Brittany J , Romito Laura , Weber Zach , Burba Jennifer , Ahmed Rami A
Published: September 2021

There are a very limited number of instruments to assess individual performance in simulation-based interprofessional education (IPE). The purpose of this study was to apply the Simulation-Based Interprofessional Teamwork Assessment Tool (SITAT) to the individualized assessment of medicine, pharmacy, and nursing students (N = 94) in a team-based IPE simulation, as well as to explore potential differences between disciplines, and calculate reliability estimates for utilization of the tool. Results of an analysis of variance provided evidence that there was no statistically significant difference among professions on overall competency ( F(2, 91)  =  0.756, P  = .472). The competency reports for nursing ( M = 3.06, SD = 0.45), medicine ( M = 3.19, SD = 0.42), and pharmacy ( M = 3.08, SD = 0.49) students were comparable across professions. Cronbach's alpha provided a reliability estimate of the tool, with evidence of high internal consistency ( α = .92). The interrater reliability of the SITAT was also investigated. There was moderate absolute agreement across the 3 faculty raters using the 2-way mixed model design and “average” unit (kappa = 0.536, P = .000, 95% CI [0.34, 0.68]). The novel SITAT demonstrates internal consistency and interrater reliability when used for evaluation of individual performance during IPE simulation. The SITAT provides value in the education and evaluation of individual students engaged in IPE curriculum.
“Church and World”
Authors: Harsveld Egbertine
Published: September 2021

The Missionary Research Library has received a number of requests for information on Kerk en Wereld, the home mission center of the Reformed Church in the Netherlands, which has attempted to carry out a broad and inclusive strategy for the evangelization of all aspects of Dutch life. The Library is, therefore, pleased to present this article by Miss Egbertine Harsveld of Groningen, the Netherlands. After her university studies at Leyden, Miss Harsveld studied theology at Basel and at union Theological Seminary in New York.– Editor.
List of Theses in Missions and Related Subjects Accepted during the Academic Year 1952–1953
Authors: Person Laura
Published: September 2021

The editor wishes to express deep gratitude to the professors of missions in fifty-four theological schools and seminaries for the reports which have made possible the compilation of the following list of theses. No theses were written in about one-half of the institutions reporting.

The annotations following the titles of theses are by the professors reporting the theses. Neither the compiler nor the editor has examined these theses or passed any judgment upon them. Each professor making a report has indicated that each particular thesis is related to foreign missions or, in a few cases, to home missions. We assume this to be the case where no annotation has been given.

Inquiries concerning a title should be addressed to the school concerned and not to the Missionary Research Library. A subject list to the theses may be found on page 8.
List of Theses in Missions and Related Subjects Accepted during the Academic Year 1953–1954
Authors: Person Laura
Published: September 2021

Replies were received from forty-six schools, thirteen of which reported no theses had been written in the field of missions. The Missionary Research Library is grateful for the cooperation of the seminaries and their professors of missions.

The annotations following the titles of theses are by the professors reporting each thesis. Neither the compiler nor the editor has examined these theses or passed Judgment upon them. Each professor making a report has indicated that each particular thesis is related to foreign missions or, in a few instances, to home missions. It is assumed that this is the case where no annotation has been given.

Inquiries concerning a title should be addressed to the school concerned and not to the Missionary Research Library. A subject list to the theses will be found on page 8.