bluuebunny/crossref_metadata_2025 huggingface dataset:
Serum Phospholipids Fatty Acids and Breast Cancer Risk by Pathological Subtype
Authors: Lope Virginia , Guerrero-Zotano Ángel , Casas Ana , Baena-Cañada José Manuel , Bermejo Begoña , Pérez-Gómez Beatriz , Criado-Navarro Inmaculada , Antolín Silvia , Sánchez-Rovira Pedro , Ramos-Vázquez Manuel , Antón Antonio , Castelló Adela , García-Saénz José Ángel , Muñoz Montserrat , de Juan Ana , Andrés Raquel , Llombart-Cussac Antonio , Hernando Blanca , Franquesa Rosa María , Caballero Rosalia , Priego-Capote Feliciano , Martín Miguel , Pollán Marina
Published: October 2020

This study evaluates whether serum phospholipids fatty acids (PL-FAs) and markers of their endogenous metabolism are associated with breast cancer (BC) subtypes. EpiGEICAM is a Spanish multicenter matched case-control study. A lifestyle and food frequency questionnaire was completed by 1017 BC cases and healthy women pairs. Serum PL-FA percentages were measured by gas chromatography-mass spectrometry. Conditional and multinomial logistic regression models were used to quantify the association of PL-FA tertiles with BC risk, overall and by pathological subtype (luminal, HER2+ and triple negative). Stratified analyses by body mass index and menopausal status were also performed. Serum PL-FAs were measured in 795 (78%) pairs. Women with high serum levels of stearic acid (odds ratio (OR)T3vsT1 = 0.44; 95% confidence interval (CI) = 0.30–0.66), linoleic acid (ORT3vsT1 = 0.66; 95% CI = 0.49–0.90) and arachidonic to dihomo-γ-linolenic acid ratio (OR T3vsT1 = 0.64; 95% CI = 0.48–0.84) presented lower BC risk. Participants with high concentrations of palmitoleic acid (ORT3vsT1 = 1.65; 95% CI = 1.20–2.26), trans-ruminant palmitelaidic acid (ORT3vsT1 = 1.51; 95% CI = 1.12–2.02), trans-industrial elaidic acid (ORT3vsT1 = 1.52; 95% CI = 1.14–2.03), and high oleic to stearic acid ratio (ORT3vsT1 = 2.04; 95% CI = 1.45–2.87) showed higher risk. These associations were similar in all BC pathological subtypes. Our results emphasize the importance of analyzing fatty acids individually, as well as the desaturase activity indices.
Impact of Strategies for Preventing Obesity and Risk Factors for Eating Disorders among Adolescents: A Systematic Review
Authors: Leme Ana Carolina B. , Haines Jess , Tang Lisa , Dunker Karin L. L. , Philippi Sonia T. , Fisberg Mauro , Ferrari Gerson L. , Fisberg Regina M.
Published: October 2020

An effective behavior change program is the first line of prevention for youth obesity. However, effectiveness in prevention of adolescent obesity requires several approaches, with special attention paid to disordered eating behaviors and psychological support, among other environmental factors. The aim of this systematic review is to compare the impact of two types of obesity prevention programs, inclusive of behavior change components, on weight outcomes. “Energy-balance” studies are aimed at reducing calories from high-energy sources and increasing physical activity (PA) levels, while “shared risk factors for obesity and eating disorders” focus on reducing disordered eating behaviors to promote a positive food and eating relationship. A systematic search of ProQuest, PubMed, PsycInfo, SciELO, and Web of Science identified 8825 articles. Thirty-five studies were included in the review, of which 20 regarded “energy-balance” and 15 “shared risk factors for obesity and eating disorders”. “Energy-balance” studies were unable to support maintenance weight status, diet, and PA. “Shared risk factors for obesity and eating disorders” programs also did not result in significant differences in weight status over time. However, the majority of “shared risk factors for obesity and eating disorders” studies demonstrated reduced body dissatisfaction, dieting, and weight-control behaviors. Research is needed to examine how a shared risk factor approach can address both obesity and eating disorders.
Increased Serum IgG4 Associates with Asthma and Tissue Eosinophilia in Chronic Rhinosinusitis Patients
Authors: Ramezanpour Mahnaz , Hu Hua , Lau Aden , Liu Sha , De Silva April , Bolt Harrison , Patterson Karen , Rischmueller Maureen , Psaltis Alkis J , Wormald Peter-John , Lester Susan , Vreugde Sarah
Published: October 2020

Chronic Rhinosinusitis (CRS) is a multifactorial disease where microorganisms’ innate and adaptive immunity can play a role. This study assessed the total IgG, IgG subclasses, IgE and IgA levels in serum samples from CRS and non-CRS control patients in relation to the disease severity, phenotype, histopathology and comorbidities. Total serum IgG, IgG1, IgG2, IgG3, IgG4 and IgE was determined from 10 non-CRS controls, 10 CRS without nasal polyp (CRSsNP) and 26 CRS with nasal polyp (CRSwNP) patients using ImmunoCap assays. Tissue lysates were analyzed for IgG levels by ELISA. Immunohistochemical analysis was used to measure the expression of IgE and IgG4 in tissue sections. The presence of anti-nuclear antigens (ANAs) against 12 autoantigens in sera and tissue lysates was determined by immunoblot assays. Total serum IgG/IgG1/IgG2 levels were higher in CRS patients vs. controls (p < 0.001), but were not different between CRSwNP and CRSsNP patients (p = 0.57). Serum IgG4/IgE levels were increased in CRSwNP patients compared to controls (p = 0.006), however, this relationship was attenuated by the inclusion of covariates. Serum IgG4 levels were more strongly associated with asthma (p = 0.038, exact median test) and tissue eosinophilia (Spearman’s rank rho = 0.51, p = 0.016) than IgE levels. No systemic ANAs were detected in any of the subjects tested. There was a polyclonal increase in serum immunoglobulins in CRS patients with elevated IgG4/IgE levels in CRSwNP patients having tissue eosinophilia and asthma.
Porcine Circovirus Type 2 Pathogenicity Alters Host’s Central Tolerance for Propagation
Authors: Sidler Xaver , Sydler Titus , Mateos José Maria , Klausmann Stefanie , Brugnera Enrico
Published: October 2020

Porcine circovirus type 2 (PCV2) infections and resulting diseases are a worldwide threat to pig production. PCV2 bears a uniqueness that allows for us to understand more about chronic infections and the immune system in general. The virus can be phylogenetically subdivided into PCV2a to PCV2h genotypes. Although vaccination against PCV2 has been seen to prevent the manifestation of PCV disease, PCV2 still lingers as subclinical infections in all developmental stages of pigs. The “slow and low” tactic gives PCV2 a particular advantage in a host’s immune surveillance. Since the inception of the PCV2 associated panzootic, research scientists have been trying to understand the pathogenicity of PCV2. Different research groups found that one genotype group member was more pathogenic than others. We found, in our weaner infection model with in vivo transfection of different recombinant PCV2 genotype group members that these viruses alter T cell maturation in the thymus, including host’s central tolerance. Here, we extend these original observations by showing that PCV2 infected cells were also found in proximity within the female and male reproductive organs of stillborn pig fetuses. These PCV2 pools were sufficient in infecting three and half-day-old embryos in sows. Furthermore, the dominant PCV2 group member was more pathogenic in our weaner infection model. PCV2 pre-immunocompetence infection makes PCV2 recognized by central immune tolerance as belonging to the host. This also explains why pathogenicity is not a genetically intrinsic characteristic of PCV2; however, the dominance of any one PCV2 genotype group member leads to a more efficient deletion of the T cells against that specific genotype group member in the thymus.
The Principles, Mechanisms, and Benefits of Unconventional Agents in the Treatment of Biofilm Infection
Authors: Talapko Jasminka , Škrlec Ivana
Published: October 2020

Today, researchers are looking at new ways to treat severe infections caused by resistance to standard antibiotic therapy. This is quite challenging due to the complex and interdependent relationships involved: the cause of infection–the patient–antimicrobial agents. The sessile biofilm form is essential in research to reduce resistance to very severe infections (such as ESKAPE pathogens: Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumanni, Pseudomonas aeruginosa, and Enterobacter spp). The purpose of this study is to elucidate the mechanisms of the occurrence, maintenance, and suppression of biofilm infections. One form of biofilm suppression is the efficient action of natural antagonists of bacteria—bacteriophages. Bacteriophages effectively penetrate the biofilm’s causative cells. They infect those bacterial cells and either destroy them or prevent the infection spreading. In this process, bacteriophages are specific, relatively easy to apply, and harmless to the patient. Antimicrobial peptides (AMPs) support the mechanisms of bacteriophages’ action. AMPs could also attack and destroy infectious agents on their own (even on biofilm). AMPs are simple, universal peptide molecules, mainly cationic peptides. Additional AMP research could help develop even more effective treatments of biofilm (bacteriophages, antibiotics, AMPs, nanoparticles). Here, we review recent unconventional agents, such as bacteriophages and AMPs, used for eradication of biofilm, providing an overview of potentially new biofilm treatment strategies.
Determination of Very Low Concentration of Bisphenol A in Toys and Baby Pacifiers Using Dispersive Liquid–Liquid Microextraction by In Situ Ionic Liquid Formation and High-Performance Liquid Chromatography
Authors: Vicente-Martínez Yesica , Caravaca Manuel , Soto-Meca Antonio
Published: October 2020

Bisphenol A (BPA) is a chemical compound used in the manufacturing of plastics and resins whose presence in the body in low concentrations can cause serious health problems. Due to this, there is a growing interest in the scientific community to develop analytical methods that allow quantifying trace concentrations of BPA in different types of samples. The determination of this compound in toys made of plastics that can be manipulated by children leads to an extra concern, because it is possible for BPA to enter the body by introducing these toys into the mouth. This work presents a novel procedure to the quickly and easily quantification of trace levels of BPA in samples of toys and pacifiers according to the current demanding regulations. The determination of very low levels of BPA was carried out by ionic liquid dispersive liquid–liquid microextraction (IL-DLLME) followed by high-performance liquid chromatography (HPLC). The formation in situ of the ionic liquid (IL) 1-octyl-3-methylimidazolium bis((trifluoromethane)sulfonyl)imide ([C8MIm] [NTf2]), was achieved by mixing 1-octyl-3-methylimidazolium chloride ([C8MIm]Cl) and lithium bis(trifluoromethanesulfonyl)imide ([NTf2]Li) aqueous solutions, reaching an instant dispersion whose cloud of microdrops allows the total extraction of BPA in the IL from aqueous solutions. After centrifugation, BPA concentration in the sedimented phase was determined by HPLC. The optimal experimental conditions for the microextraction and determination of BPA in the IL were studied. The total extraction was achieved at pH 4, heating the sample at 30 °C for 5 min, using 100 µL of IL precursor volume, and spinning after the formation of dispersion at 3000 rpm for 10 min. The enrichment factor (EF) and detection limit (LOD) reached with the procedure were 299 and 0.19 µg L−1, respectively. The relative standard deviation for ten replications at the 0.5 µg L−1 level was 5.2%. Recovery studies showed a mean value for BPA recovery percentage in the samples of 99%. Additionally, a hybrid model was applied to characterize the extraction kinetics. This simple, low cost and fast method simplifies traditional microextraction techniques, representing an outstanding alternative.
Antibacterial Drug-Release Polydimethylsiloxane Coating for 3D-Printing Dental Polymer: Surface Alterations and Antimicrobial Effects
Authors: Mai Hang-Nga , Hyun Dong Choon , Park Ju Hayng , Kim Do-Yeon , Lee Sang Min , Lee Du-Hyeong
Published: October 2020

Polymers are the most commonly used material for three-dimensional (3D) printing in dentistry; however, the high porosity and water absorptiveness of the material adversely influence biofilm formation on the surface of the 3D-printed dental prostheses. This study evaluated the effects of a newly developed chlorhexidine (CHX)-loaded polydimethylsiloxane (PDMS)-based coating material on the surface microstructure, surface wettability and antibacterial activity of 3D-printing dental polymer. First, mesoporous silica nanoparticles (MSN) were used to encapsulate CHX, and the combination was added to PDMS to synthesize the antibacterial agent-releasing coating substance. Then, a thin coating film was formed on the 3D-printing polymer specimens using oxygen plasma and thermal treatment. The results show that using the coating substance significantly reduced the surface irregularity and increased the hydrophobicity of the specimens. Remarkably, the culture media containing coated specimens had a significantly lower number of bacterial colony formation units than the noncoated specimens, thereby indicating the effective antibacterial activity of the coating.
Prediction of Antidepressant Treatment Response and Remission Using an Ensemble Machine Learning Framework
Authors: Lin Eugene , Kuo Po-Hsiu , Liu Yu-Li , Yu Younger W.-Y. , Yang Albert C. , Tsai Shih-Jen
Published: October 2020

In the wake of recent advances in machine learning research, the study of pharmacogenomics using predictive algorithms serves as a new paradigmatic application. In this work, our goal was to explore an ensemble machine learning approach which aims to predict probable antidepressant treatment response and remission in major depressive disorder (MDD). To discover the status of antidepressant treatments, we established an ensemble predictive model with a feature selection algorithm resulting from the analysis of genetic variants and clinical variables of 421 patients who were treated with selective serotonin reuptake inhibitors. We also compared our ensemble machine learning framework with other state-of-the-art models including multi-layer feedforward neural networks (MFNNs), logistic regression, support vector machine, C4.5 decision tree, naïve Bayes, and random forests. Our data revealed that the ensemble predictive algorithm with feature selection (using fewer biomarkers) performed comparably to other predictive algorithms (such as MFNNs and logistic regression) to derive the perplexing relationship between biomarkers and the status of antidepressant treatments. Our study demonstrates that the ensemble machine learning framework may present a useful technique to create bioinformatics tools for discriminating non-responders from responders prior to antidepressant treatments.
Dimethyl Fumarate and Its Esters: A Drug with Broad Clinical Utility?
Authors: Kourakis Stephanie , Timpani Cara A. , de Haan Judy B. , Gueven Nuri , Fischer Dirk , Rybalka Emma
Published: October 2020

Fumaric acid esters (FAEs) are small molecules with anti-oxidative, anti-inflammatory and immune-modulating effects. Dimethyl fumarate (DMF) is the best characterised FAE and is approved and registered for the treatment of psoriasis and Relapsing-Remitting Multiple Sclerosis (RRMS). Psoriasis and RRMS share an immune-mediated aetiology, driven by severe inflammation and oxidative stress. DMF, as well as monomethyl fumarate and diroximel fumarate, are commonly prescribed first-line agents with favourable safety and efficacy profiles. The potential benefits of FAEs against other diseases that appear pathogenically different but share the pathologies of oxidative stress and inflammation are currently investigated.
Recent Progress of Chitosan and Chitosan Derivatives-Based Nanoparticles: Pharmaceutical Perspectives of Oral Insulin Delivery
Authors: Seyam Salma , Nordin Norsyafikah Asyilla , Alfatama Mulham
Published: October 2020

Diabetes mellitus is a chronic endocrine disease, affecting more than 400 million people around the world. Patients with poorly controlled blood glucose levels are liable to suffer from life-threatening complications, such as cardiovascular, neuropathy, retinopathy and even premature death. Today, subcutaneous parenteral is still the most common route for insulin therapy. Oral insulin administration is favourable and convenient to the patients. In contrast to injection route, oral insulin delivery mimics the physiological pathway of endogenous insulin secretion. However, oral insulin has poor bioavailability (less than 2%) due to the harsh physiological environment through the gastrointestinal tract (GIT). Over the last few decades, many attempts have been made to achieve an effective oral insulin formulation with high bioavailability using insulin encapsulation into nanoparticles as advanced technology. Various natural polymers have been employed to fabricate nanoparticles as a delivery vehicle for insulin oral administration. Chitosan, a natural polymer, is extensively studied due to the attractive properties, such as biodegradability, biocompatibility, bioactivity, nontoxicity and polycationic nature. Numerous studies were conducted to evaluate chitosan and chitosan derivatives-based nanoparticles capabilities for oral insulin delivery. This review highlights strategies that have been applied in the recent five years to fabricate chitosan/chitosan derivatives-based nanoparticles for oral insulin delivery. A summary of the barriers hurdle insulin absorption rendering its low bioavailability such as physical, chemical and enzymatic barriers are highlighted with an emphasis on the most common methods of chitosan nanoparticles preparation. Nanocarriers are able to improve the absorption of insulin through GIT, deliver insulin to the blood circulation and lower blood glucose levels. In spite of some drawbacks encountered in this technology, chitosan and chitosan derivatives-based nanoparticles are greatly promising entities for oral insulin delivery.
VUOIŊŊALAŠVUOHTA—Sámi Spirituality, Yoik and Its Relations
Authors: Sharma Vassvik Tuula
Published: October 2020

The subject of identity is important in today’s political landscape. This article explores the way in which indigenous identity in particular is a contested subject, taking into account the way indigeneity in itself was, and still is, created within colonial contexts. The “validity” of indigenous peoples and their political aims, as well as their right to live according to their own cultural paths, will often be determined according to racist ideas connected to authenticity and its stereotypical demands. Such concepts can furthermore turn inward, disconnecting indigenous peoples from their own heritage. How ideas of authenticity affect indigenous individuals and their processes of identification serves as a central question within this text. Central to the Standing Rock movement was the focus on spirituality and religion grounded in Lakota traditions and other indigenous cultures. The text accounts for how these practices affected Marielle Beaska Gaup, Sámi artist, activist, and mother, especially through her experiences as a juoigi, a traditional Sámi yoiker. The ever-present singing and drumming at camp, chiefly during the summer, tied the mundane and ritualistic together, a characteristic mirroring traditional Lakota and Sámi ways of life, in which the spiritual at times seem to be an integral part of daily life. Building upon Marielle’s observations, the text looks at the way indigenous people’s relationships with spiritual traditions can affect processes of identification, and how indigenous identity can be intimately link to its spiritual heritage. This article employs indigenous methodologies, centering research on Sámi and indigenous perspectives, values and agendas. Marielle’s reflections contribute to the exploration of the connections between spirituality and Sámi identities; furthermore, they enable us to connect ideas about moving beyond the authoritarian ideals of “authentic identities”, through re-centering on indigenous experiences and processes of identification My main source is Marielle’s interview and articles based on interviews with people from Standing Rock The analysis centers on Marielle’s thoughts together with my own, with support from indigenous researchers bringing their own knowledge about identity and spirituality forward.
Spiritual Struggles of Nones and ‘Spiritual but Not Religious’ (SBNRs)
Authors: Mercadante Linda
Published: October 2020

Spiritual struggles are a distinct problem which have implications for psychological, social, emotional and physical health. They are not unique to religious persons; instead both the religiously unaffiliated (Nones) and those who call themselves “Spiritual but not Religious,” (SBNR) have struggles with existential issues common to all humans, and which can be identified as “spiritual”. Nones are a very diverse group and different types of Nones struggle differently. This qualitative study, based on interviews in North America with over 100 Nones, particularly SBNRs, explains the types of spiritual struggles, with many examples and illustrative quotes. Nones’ key struggles are in the areas of Self and Self-in-Relation. This is a vastly under-researched topic which will only grow in importance, given the rapid and continuing rise of the None population. The topic is of concern to social scientists, but is equally important for psychologists, counselors, medical personnel, chaplains and others in the helping professions given that Nones will come to them for assistance.
Reconciling the God of Traditional Theism with the World’s Evils
Authors: Attfield Robin
Published: October 2020

Replying to James Sterba’s argument for the incompatibility of the world’s evils with the existence of the God of traditional theism, I argue for their compatibility, using the proposition that God has reasons for permitting these evils. Developing this case involves appeal to an enlarged version of both the Free Will Defence and Hick’s Vale of Soul-Making Defence, in the context of God’s decision to generate the kind of natural regularities conducive to the evolution of a range of creatures, including free and rational ones. Sterba writes as if God would be required to authorise frequent infringements of these regularities. Sterba’s arguments from ethics and from the inadequacy of post-mortem compensation are problematised. Predicates used of God must bear a sense appropriate to the level of creator, and not of a very powerful cosmic observer. The ethics that applies within creation should not be confused with the ethics of creating.
Exclusionary Populism and Islamophobia: A Comparative Analysis of Italy and Spain
Authors: Cervi Laura
Published: October 2020

Exclusionary populism is well known for twisting real grievances of the citizens, by problematizing the gap between “us” and “them”, capitalizing on identity lines, calling out as “others” those who do not share “pure people’s” identity and culture. Especially after 9/11, Muslims have become the ideal-type of “other”, making Islamophobia the primary populist anti-paradigm. This article contributes to the burgeoning literature on Islamophobic populism analyzing the presence of Islamophobia in the electoral discourse of Vox party in Spain and Lega in Italy. In addition, it makes a novel contribution by discussing and testing the existence of different models of Islamophobia, distinguishing between “banal Islamophobia” and “ontological Islamophobia”. Applying clause-based semantic text analysis—including qualitative and quantitative variables—to thirty speeches by the two party leaders, Santiago Abascal and Matteo Salvini, during the last three elections (General, Regional and European), the paper concludes that, despite the similarities, the two politician display two different models of Islamophobia. Whereas Abascal displays a clear “ontological Islamophobia”, depicting Muslims ontologically incompatible with Spanish civilization (defined precisely by its anti-Muslim history), the latter presents a mix of arguments that oscillate between “ontological” and “banal” Islamophobia.
Ritual Void or Ritual Muddle? Deconsecration Rites of Roman Catholic Church Buildings
Authors: de Wildt Kim
Published: October 2020

The decrease in people who regularly celebrate liturgy in western Europe has led to the question of what to do with so-called obsolete church buildings. This question not only refers to whether or not a church building will be converted, reused or demolished, but also to the question of whether or not such a building needs to be deconsecrated, and if so, what does deconsecration of a church building actually entail? In this contribution, I will consider the role deconsecration rites play in the Roman Catholic church when a church building is taken out of liturgical use. In Roman Catholic liturgy, there are no prescribed, official deconsecration rites that are mandatory for a church building that is to be taken out of liturgical use. The actual deconsecration of a church building is, according to canon law, established by a decree that is issued by the responsible diocesan bishop. In the case of a church being taken out of liturgical use, however, there seems to be a shift from having a ritual void with regard to deconsecration rites, and also a focus on the “legitimate” way (in the sense of canon law) to deconsecrate a church building (object orientation), towards, in recent decades, paying more attention to a growing pastoral need (subject orientation) for deconsecration rites. These new ritual initiatives can be regarded as forms of pastoral care intended to help parishioners cope with the loss of their church building. I will show that different interpretations of canon law articles complicate straightforward answers to the question of which arguments are legitimate to deconsecrate a church. Furthermore, I will address the “ritual muddle”, the mixture of the actual deconsecration act in the sense of canon law and deconsecration rites that, from the perspective of canon law, do not effect church deconsecration. I will also address the differentiation between desecration and deconsecration, address historical forms of deconsecration rites and pay attention to the making and unmaking of sacred space. Finally, I will focus on contemporary deconsecration rites against the background of the complex reality in which such rites are situated.
Funded Research in Relation to Curriculum Development—Tendencies in Religious Education in Sweden 2001–2019
Authors: Osbeck Christina , Franck Olof
Published: October 2020

In 2001, the Swedish Research Council (VR) set up a new section to expand educational research. The section has now existed for almost 20 years without receiving much attention within research. During the same period, the demands on teachers to base their teaching on research have increased, e.g., through the revised Education Act, which can be understood as presupposing available relevant research and a research-based curriculum. In this article, the focus of funded research projects relevant to religious education (RE) during these years is explored. The resulting patterns are discussed against the background of published RE research and put in relation to a study of curriculum changes in Sweden during the same period. The overall aim of this paper is to discuss the relationship between RE research and RE curricula in Sweden. The study is conducted through content analyses of project applications and reports to VR, and of curricula. The research interest of the projects concerning ‘religion’ and ‘ethics’ are presented, and their possible contribution to curriculum development is also outlined. The absence of obvious research influence on current curriculum development suggests further research on this topic is required, since the legitimacy of the curriculum can be understood to be dependent on its being based on research.
Religious Hallucinations and Religious Delusions among Older Adults in Treatment for Psychoses in the Netherlands
Authors: Noort Annemarie , Beekman Aartjan T. F. , Braam Arjan W.
Published: October 2020

Background. Although religious delusions (RDs) are common in geriatric psychiatry, we know little about their frequency and content. Our study examines the prevalence and content of religious hallucinations (RHs) and RDs and how they relate to the diagnosis and the patients’ denominational background and other aspects of religiousness. Methods. Semi-structured diagnostic interviews were conducted with inpatients and outpatients (N = 155, mean age 76.5) at a geriatric psychiatry department in the Netherlands. We used the Schedules for Clinical Assessment in Neuropsychiatry 2.1. Results. The prevalences of RHs and RDs were 19% and 32%, respectively. RHs were mostly auditory. There was no statistically significant difference between the prevalence of RHs in schizophrenia (17.5%) and in psychotic depression (9.4%). Compared to non-affiliated patients and mainline Protestants, RDs were significantly more prevalent in raised and current strict Protestants, especially in those with psychotic depression. RHs were more prevalent in Evangelical (e.g., Pentecostal) and strict Protestant patients. The presence of RDs was associated with several measures of religiousness (e.g., dogmatism, religious coping). Conclusions. Religion is likely to act as a symptom-formation factor for psychotic symptoms in strict Protestant older adults. More detailed research might lead to a fuller understanding of how strict religious beliefs may affect the content of psychotic symptoms and unintentionally add a component of existential suffering. It is important for mental health professionals, especially the predominantly secular professionals in the Netherlands, to recognize and address religious themes.
Paratexts Seeking Understanding: Manuscripts and Aesthetic Cognitivism
Authors: Allen Garrick V. , Royle Anthony P.
Published: October 2020

This article explores the relationship between manuscripts of ancient religious literature and aesthetic cognitivism, a normative theory of the value of art. Arguing that manuscripts both contain and constitute works of art, we explore paratextuality as a phenomenon that connects manuscript studies to both qualitative and quantitative sides of aesthetic cognitivism. Focusing on our work with a single unpublished gospel manuscript (Dublin, CBL W 139) in the context of a larger project called Paratextual Understanding, we make that case that paratexts have aesthetic functions that allow them to contribute to the knowledge yielded by the larger literary work of which they are a part. We suggest a number of avenues for further research that engages with material culture, non-typography, paratexts, and the arts.
Controversial Issues and the Rhetoric of Common Values
Authors: Iversen Lars Laird
Published: October 2020

In this article, I identify a broad, international ‘rhetoric of common values’, which hinges on the poorly supported assumption that values should be promoted because the sharing of values are the basis for social cohesion in groups. Through discussing two cases, I identify, analyse and critique key features of the empirical phenomenon that I call the rhetoric of common values. The two cases are the British government response to the so-called ’Trojan Horse’ incident in 2014, and Norwegian core curricula since 1974. Previous research has critiqued the use of the term ’fundamental British values’ as being unhelpful when schools teach controversial issues. The results of my analysis provide international breadth, some historical depth and metaphorical structure to our understanding of how the rhetoric of common values is used in education policy today. The article focusses less on dilemmas faced by teachers and more on the context of choice established ‘upstream’ by education policy. I argue that it is timely and important for teachers in religious education to understand the rhetoric of common values. It is a contemporary and politically relevant way in which religion is mobilised and politicised for exclusionary forms of national identity. Avoiding the rhetoric of common values does not mean avoiding values in education policy. The rhetoric of common values identitizes values. This causes the terms ‘values’ to be mobilised in boundary work separating ‘us’ from ‘them’, thus undercutting a better role of values in education policy: to reflect upon, and make relevant in life, guidelines for future action.
On the Benefits of Color Information for Feature Matching in Outdoor Environments
Authors: Hoffmann Annika
Published: October 2020

The detection and description of features is one basic technique for many visual robot navigation systems in both indoor and outdoor environments. Matched features from two or more images are used to solve navigation problems, e.g., by establishing spatial relationships between different poses in which the robot captured the images. Feature detection and description is particularly challenging in outdoor environments, and widely used grayscale methods lead to high numbers of outliers. In this paper, we analyze the use of color information for keypoint detection and description. We consider grayscale and color-based detectors and descriptors, as well as combinations of them, and evaluate their matching performance. We demonstrate that the use of color information for feature detection and description markedly increases the matching performance.
Energy–Momentum Pseudotensor and Superpotential for Generally Covariant Theories of Gravity of General Form
Authors: Ilin Roman , Paston Sergey
Published: October 2020

The current paper is devoted to the investigation of the general form of the energy–momentum pseudotensor (pEMT) and the corresponding superpotential for the wide class of theories. The only requirement for such a theory is the general covariance of the action without any restrictions on the order of derivatives of the independent variables in it or their transformation laws. As a result of the generalized Noether procedure, we obtain a recurrent chain of the equations, which allows one to express canonical pEMT as a divergence of the superpotential. The explicit expression for this superpotential is also given. We discuss the structure of the obtained expressions and the conditions for the derived pEMT conservation laws to be satisfied independently (fully or partially) by the equations of motion. Deformations of the superpotential form for theories with a change in the independent variables in action are also considered. We apply these results to some interesting particular cases: general relativity and its modifications, particularly mimetic gravity and Regge–Teitelboim embedding gravity.
Impact of Microbiota: A Paradigm for Evolving Herd Immunity against Viral Diseases
Authors: Shelly Asha , Gupta Priya , Ahuja Rahul , Srichandan Sudeepa , Meena Jairam , Majumdar Tanmay
Published: October 2020

Herd immunity is the most critical and essential prophylactic intervention that delivers protection against infectious diseases at both the individual and community level. This process of natural vaccination is immensely pertinent to the current context of a pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection around the globe. The conventional idea of herd immunity is based on efficient transmission of pathogens and developing natural immunity within a population. This is entirely encouraging while fighting against any disease in pandemic circumstances. A spatial community is occupied by people having variable resistance capacity against a pathogen. Protection efficacy against once very common diseases like smallpox, poliovirus or measles has been possible only because of either natural vaccination through contagious infections or expanded immunization programs among communities. This has led to achieving herd immunity in some cohorts. The microbiome plays an essential role in developing the body’s immune cells for the emerging competent vaccination process, ensuring herd immunity. Frequency of interaction among microbiota, metabolic nutrients and individual immunity preserve the degree of vaccine effectiveness against several pathogens. Microbiome symbiosis regulates pathogen transmissibility and the success of vaccination among different age groups. Imbalance of nutrients perturbs microbiota and abrogates immunity. Thus, a particular population can become vulnerable to the infection. Intestinal dysbiosis leads to environmental enteropathy (EE). As a consequence, the generation of herd immunity can either be delayed or not start in a particular cohort. Moreover, disparities of the protective response of many vaccines in developing countries outside of developed countries are due to inconsistencies of healthy microbiota among the individuals. We suggested that pan-India poliovirus vaccination program, capable of inducing herd immunity among communities for the last 30 years, may also influence the inception of natural course of heterologous immunity against SARS-CoV-2 infection. Nonetheless, this anamnestic recall is somewhat counterintuitive, as antibody generation against original antigens of SARS-CoV-2 will be subdued due to original antigenic sin.
House Dust Mite Exposure Causes Increased Susceptibility of Nasal Epithelial Cells to Adenovirus Infection
Authors: Aydin Malik , Naumova Ella A. , Paulsen Friedrich , Zhang Wenli , Gopon Felix , Theis Christian , Lutz Sören , Ehrke-Schulz Eric , Arnold Wolfgang H. , Wirth Stefan , Ehrhardt Anja
Published: October 2020

Adenovirus (AdV) infections in the respiratory tract may cause asthma exacerbation and allergic predisposition, and the house dust mite (HDM) may aggravate virus-induced asthma exacerbations. However, the underlying mechanisms of whether and how AdV affects asthmatic patients remains unclear. To address this question, we investigated nasal epithelial cells (NAEPCs) derived from a pediatric exacerbation study cohort for experimental analyses. We analyzed twenty-one different green-fluorescent protein- and luciferase-tagged AdV types in submerged 2D and organotypic 3D cell culture models. Transduction experiments revealed robust transduction of AdV type 5 (AdV5) in NAEPCs, which was associated with an increased uptake of AdV5 in the presence of HDM. In healthy and asthmatic NAEPCs exposed to HDM before infection, we observed a time- and dose-dependent increase of AdV5 uptake associated with upregulation of entry receptors for AdV5. Furthermore, electron microscopic and histologic analyses of 3D cell cultures revealed an impairment of the respiratory cilia after HDM exposition. This ex vivo pilot study shows the impact of AdV infection and HDM exposition in a primary cell culture model for asthma.
When school comes home: How low-income families are adapting to distance learning
Authors: Aguilar Stephen J , Galperin Hernan , Baek Clare , Gonzalez Eduardo
Published: October 2020

School campus closures due to COVID-19 forced transition to remote learning in March 2020, which continues in Fall 2020. Remote learning measures presents multiple challenges for low-income, minority families, and these families have been disproportionately affected by the COVID-19 crisis. We sought to understand the challenges they faced, including the lack of Internet access and devices, digital skills and lack of appropriate learning space at home.
Architecture of 2X2 FIR Filter using Vedic Multiplier and Brent-Kung Adder
Authors:   Professor, Department of ECE, Technocrats Institute of Technology, Bhopal (M.P), India., Bhatt* Dr. Abhishek , Ms. Fatima  ,   M.Tech Scholar, Department of ECE, Technocrats Institute of Technology, Bhopal (M.P), India.
Published: October 2020

This paper proposed, a 2X2 FIR filter which is based on the Brent-Kung adder and Vedic multiplier. A 2X2 FIR filter has been designed using Brent-Kung-Adder (BKA) and filter coefficient. Verilog platform and Xilinx 14.5 software. The Brent- Kung adder is much faster than the look ahead carry adder (LACD), carry select adder and ripple carry adder (RCA) and it is a parallel prefix adder. Lowarea and the power consumption in Brent-kung adder is also less as compared to various adders. Multiplication of a number using the Vedic multiplier is arithmetic key operation to be performed with low power consumption of and increase the speed in the consequence applications. Proposed design utilize the common multiplication in cross multiply to compensate the problem of delay which is occurring in the Booth Multiplier and Array Multiplier and etc. Brent-kung adder used to decrease the delay which was occur in the multiplier and significantly reduce the quantity of logic elements such as gates, signals etc.
O ALEITAMENTO MATERNO EM TEMPOS DE PANDEMIA POR COVID-19 E A ATUAÇÃO EMPREENDEDORA DO ENFERMEIRO
Authors: França Niquélen Bianca Miller , Lourenço Bruno da Silva , Fernandes Ilma Marques , Oliveira Helaine Maria da Silva , Praun Teresinha Herdvig , Silva Janaina Rosa Lourenço da
Published: October 2020

Objetivos: Descrever os aspectos que envolvem o aleitamento materno em tempos de pandemia e discutir as ações do enfermeiro em sua prática empreendedora. Metodologia: Trata-se de estudo reflexivo consubstanciado por fontes secundárias da literatura pertinente à temática, considerando artigos de periódicos nacionais e internacionais e produções recentes sobre aleitamento materno, saúde da mulher, enfermagem e o Covid-19. Resultados: O enfermeiro junto a sua equipe, deve investir em estratégias que possam minimizar tais entraves, a fim de fortalecer o afeto entre o binômio. Para isso é relevante impulsionar a puérpera a se perceber e assim, identificar o que ela pode oferecer ao seu RN. Conclusão: Ao enfermeiro empreendedor cabe desmistificar hábitos, costumes e embasar cientificamente técnicas que viabilize o aleitamento e esclarecimento de dúvidas a respeito e para tal têm que ter habilidades e cuidado de não emitir julgo sobre como essa relação entre binômio deve acontecer.
Esquemas tributarios de las entidades No lucrativas en México
Authors: Paz Pérez Daniel Eduardo
Published: October 2020

Las entidades no lucrativas juegan un papel importante desde la iniciativa social, ya que realizan un amplio rango de actividades: desde lo asistencial hasta lo filantrópico, sin ánimo de especulación comercial. El objetivo de esta investigación fue mostrar cómo tributan estas entidades, así como su evolución en el sistema tributario mexicano, utilizando el análisis documental histórico y el método interpretativo exegético a partir de la legislación mexicana en el siglo XX. El principal hallazgo es el reconocimiento de las organizaciones a las que se les ha ido concediendo la exención tributaria en las leyes mexicanas de renta, así como los esquemas tributarios que le son aplicables a las entidades no lucrativas en la legislación vigente.
Pengaruh Kecerdasan Emosional Terhadap Motivasi Belajar Matematika Siswa Kelas IV SD Negeri 1 Ngulankulon
Authors: Sidik Fitriana As , Febriandari Efi Ika , Setiawan Angga
Published: October 2020

This study aims to determine the level of emotional intelligence, find out the motivation to learn mathematics and determine the effect of emotional intelligence on motivation to learn mathematics. Using quantitative research with survey methods. Population and sample of all fourth grade students with 21 students. Data obtained by observation and disseminating the first questionnaire aims to find out emotional intelligence and the second questionnaire to determine student motivation. The research instrument uses a scale of emotional intelligence and motivation to learn mathematics. Descriptive analysis results show that the emotional intelligence of class IV students is in the medium category with a percentage of 14%, while the motivation to learn mathematics in class IV is in the moderate category with a percentage of 29%. After analyzing the data it is known that there is a significant influence with the results of r count = 16.991 and consulted with a value of t table = 1.729. While the influence of variable X (emotional intelligence) on the Y variable (mathematics learning motivation) was 93.8%. With these results, the alternative hypothesis is accepted and the null hypothesis is rejected. It can be concluded that there is a significant influence of the influence of emotional intelligence on mathematics learning motivation of fourth grade students of SD Negeri 1 Ngulankulon.
Research note: The scale of Facebook’s problem depends upon how ‘fake news’ is classified
Authors: Rogers Richard
Published: October 2020

Ushering in the contemporary ‘fake news’ crisis, Craig Silverman of Buzzfeed News reported that it outperformed mainstream news on Facebook in the three months prior to the 2016 US presidential elections. Here the report’s methods and findings are revisited for 2020. Examining Facebook user engagement of election-related stories, and applying Silverman’s classification of fake news, it was found that the problem has worsened, implying that the measures undertaken to date have not remedied the issue. If, however, one were to classify ‘fake news’ in a stricter fashion, as Facebook as well as certain media organizations do with the notion of ‘false news’, the scale of the problem shrinks. A smaller scale problem could imply a greater role for fact-checkers (rather than deferring to mass-scale content moderation), while a larger one could lead to the further politicisation of source adjudication, where labelling particular sources broadly as ‘fake’, ‘problematic’ and/or ‘junk’ results in backlash.
Influence of Social Cultural Factors on HIV Seropositivity Disclosure to Sexual Partners in Kenya
Authors: Ngige Lucy W , Ndayala Phoebe D
Published: October 2020

The purpose of the study was to assess whether sociocultural factors have an influence on the self-disclosure of HIV serostatus to intimate partners among People Living with HIV and AIDS (PLWHA). A survey was conducted among 232 randomly selected respondents who were HIV seropositive and were members of a registered community-based support group for PLWHA in Nairobi, Kenya. Data was gathered by means of semi-structured interviews and focus group discussions. Results revealed that the marital status of the respondents varied from never married (13.4%), married (27.6%), separated (26.3%), divorced (4.3%) and widowed (28.4%). Approximately half of the respondents (50.4%) had disclosed their HIV serostatus to their intimate partners while 49.6% had not. The binary logistic regression results established that some socio-cultural factors fostered HIV seropositivity disclosure while others did not. The positive predictors of HIV serostatus disclosure were gender inequalities in the sexual relationship (AOR=4.129; p=0.011), the role of females as dependent housewives (AOR=1.322; P=0.004), anticipated divorce following HIV disclosure (AOR=2.578; p=0.014) and the cultural belief that HIV was a curse (AOR=2.444; p=0.005). However, sexual behaviour such as homosexuality, rape, incest, sex with minors and extramarital sex (AOR=0.225; p=0.001), intimate partner violence (AOR=0.220; p=0.001), the subordination of females by their male partners (AOR=0.351; p=0.002) and the fear of exclusion from the cultural rite of wife inheritance during widowhood (AOR=0.410; p=0.002) were negative predictors of disclosure of HIV serostatus. This implies that there was no likelihood of HIV disclosure, thereby putting intimate partners at risk of HIV infection. It was recommended that there was the need to promote community discourse on HIV and AIDS in order to reduce the socio-cultural barriers to self-disclosure of HIV seropositive status and to increase the community acceptance of people living with HIV and AIDS.