bluuebunny/crossref_metadata_2025 huggingface dataset:
Development of Android-Based Learning Media in Computer and Basic Network Lessons Class X TKJ Cokroaminoto Vocational High School, Kotamobagu
Authors: Pelealu Ray Rivay Anugrah Aer , Oroh Rolly Robert , Rompas Parabelem T.D
Published: March 2024

Cokroaminoto Kotamobagu Vocational School is an educational institution that aims to develop the potential of the nation's children so they can compete at the world level. To fulfill these objectives, educational institutions need to be equipped with adequate computer networks. This study aims to develop learning media based on Android (m-learning) on the subject of Applying IP Addressing to Computer Networks for class X SMK Cokroaminoto Kotamobagu. The research method used in this research is research and development (R&D). The steps taken are Potential and Problems, Gathering Information, Product Design, Design Validation, Design Improvement, Product Trials, Revision of potentials and problems, data collection, product design, design validation, design revisions, product trials, and product revisions. After the product trials were carried out with two stages, namely small group trials carried out by twelve students, and wide trials carried out twice, the first stage was carried out by one teacher, and the second stage by thirty-four participants educated. From the product trials, the results regarding the android-based m-learning application in the material Applying IP Addressing on Computer Networks obtained an assessment with very feasible criteria based on the teacher's assessment and very interesting based on the student's assessment.
Leadership Type for Accelerating Digital Transformation at the Sub-District Level
Authors: Mamuaja Marlin Penina , Rawis Joulanda A.M. , Tambingon Henny N. , Kambey Joseph
Published: March 2024

Each leader types the other's leadership. Camat Tondano Selatan which has been relatively considered successful make researcher interested In knowing the type of leadership that belongs to Camat. Digital transformation has become a very important thing in increasing the quality of service in the public-level district. However, transformation needs effective leadership to reach optimal results. This article aims to analyze the type of most effective leadership in pushing digital transformation on the level district. The method used in this research is method study comparison. The comparison was done between two of the variables studied to see variable tendencies. Amount of whole office employee subdistrict South Tondano totaled 22 people plus 8 Lurah, a total of 30 people. because amount employees plus the village chief only 30 people then in the study This researcher use whole officials and village heads as sample research. Research results show that the average value of the answers questionnaire from respondent research is 4.1567 for type leadership transformational and 3.2767 for type leadership transactional. In other words employees in the District and Lurah are in the District area Tondano Selatan assessed that type the of the leadership of the Camat Tondano Selatan is more tend to Type Leadership transformational compared to with the type of leadership transactional. The result is a significant difference between the second type of average value leadership. it can be seen in the t value of 48.280 which is significant at an alpha value of 0.5. Research results also show that type of effective leadership in speeding up digital transformation at the level subdistrict is leadership transformational and leadership participatory. Leadership transformational can push innovation and creativity in the development of digital solutions, meanwhile, leadership participatory can increase the involvement of staff in the digital transformation process. Study This recommends that the head district and related staff with digital transformation in the sub-district must adopt type leadership transformational and participatory for speeding up digital transformation at the level district.
Future Trends for Direction in Enterprise Architecture: Systematic Literature Review
Authors: Batmetan Johan Reimon , Rawis Joulanda A.M. , Lengkong Jeffry Sony Junus , Rotty Viktory Nicodemus Joufree
Published: March 2024

In the modern business era, enterprise architecture is becoming increasingly important for companies to achieve their business goals. However, designing and implementing an effective enterprise architecture can be challenging, especially due to the ever-increasing complexity of information systems, changing business needs, and pressure to continually improve efficiency and performance. This study aims to analyze the literature review to map future trends in enterprise architecture related to technological developments and business needs. The research method used This study was conducted by conducting a systematic literature search using leading academic databases such as Scopus, Web of Science, and IEEE Xplore. Inclusion and exclusion criteria have been established to ensure that the selected articles are relevant to the topics discussed. Articles that met the inclusion criteria were then analyzed and critically assessed to identify trends in enterprise architecture. The results of this study produce arguments for the importance of enterprise architecture in helping companies to operate efficiently and integrate different systems and applications. The results of this study indicate that the future trends and topics of enterprise architecture help organizations achieve strategic goals and enable companies to adapt quickly to changes in business and technology. This study concludes that future trends in enterprise architecture can help companies adopt future information technology trends in enterprise architecture. The findings in this study have significant practical implications for enterprise architecture practices. Enterprises should take these trends into account when designing and deploying their enterprise architecture, to ensure that they maximize the benefits of the latest technologies and meet changing business needs.
An Investigation of E-Learning Readiness in Vocational High School During the Post Pandemic Covid-19: Case from North Sulawesi
Authors: Batmetan Johan Reimon , Katuuk Deitje Adolfien , Lengkong Jeffry Sony Junus , Rotty Viktory Nicodemus Joufree
Published: March 2024

The COVID-19 pandemic has changed the learning model in vocational high schools in Indonesia, which is usually face-to-face and has been turned into online learning. This learning uses e-learning with several models such as synchronous learning and asynchronous learning drastically without proper preparation. This creates problems in achieving learning outcomes because of many inhibiting factors. This research aims to investigate the readiness of e-learning implemented in vocational high schools during the post COVID-19 pandemic. The method used is the Aydin & Tasci ELR model for measuring the level of e-learning readiness. The results of this research investigation found that the e-learning readiness score was 4.15, which means that vocational high schools in Indonesia are ready to implement e-learning but still need a slight improvement in several factors. These factors are human resources, organization, technology, and infrastructure. This research concludes that vocational high schools in Indonesia are ready to implement e-learning as a supporter of learning in schools.
Strengthening the Acceleration of Digital Transformation in Developing a Digital Economy Curriculum
Authors: Tiwow Gilly Marlya , Rawis Joulanda A.M. , Lengkong Jeffry Sony Junus , Rotty Viktory Nicodemus Joufree
Published: March 2024

This study aims to analyze and identify effective strategies to accelerate digital transformation in developing digital economy curricula. Digital transformation has brought significant changes in various sectors, including the economic sector. In the context of education, curriculum development that is responsive to the needs of the digital economy is crucial in preparing students to face the demands of the ever-evolving world of work. This study will use qualitative and quantitative approaches to collect and analyze data. Through a comprehensive literature review, this research will identify best practices in digital economy curriculum development in various educational institutions. Furthermore, this research will conduct interviews with key stakeholders, such as educators, digital industry representatives, and education experts, to gain an in-depth understanding of the challenges and opportunities associated with digital transformation in developing digital economy curricula. The collected data will be analyzed using qualitative methods such as content analysis and thematic analysis, as well as quantitative methods such as descriptive statistics and factor analysis. This analysis will provide in-depth insight into the factors that influence the success of digital transformation in digital economy curriculum development, including challenges, training needs, available resources, and effective implementation strategies. The results of this study are expected to provide recommendations for education policymakers, curriculum developers, and educational institutions to strengthen their efforts in implementing digital transformation in developing digital economy curricula. It is also hoped that this research can contribute to our understanding of how digital economic education can prepare future generations to become competitive actors in the digital era.
Web-Based Academic Information Systems in Vocational School
Authors: Lengkong Jeffry Sony Junus , Jacobus Susan N H , Dondokambey Robby , Ratumbuisang Keith F. , Paath Deicy , Liow Evans S.
Published: March 2024

An academic information system is an application that can facilitate to processing of data and information related to academic problems. Currently, SMK Negeri 1 Tondano as one of the vocational schools in North Sulawesi still uses manual methods in processing the data and information needs, so it feels less effective and efficient. This causes the data process to not be integrated properly, and it takes a long time to process data or information. This research was conducted to develop a web-based academic information system at SMK Negeri 1 Tondano. Where this information system is expected to be able to help the data and information processing process. In developing the system to be built, the research method used is the prototype development method and Unified Modeling Language (UML) modeling to simplify the design of the system to be built. Based on the results of system testing using black-box testing, it is stated that the system can run as well as expected.
Developing Instructional Media for Vocational School Students
Authors: Rawis Joulanda A.M. , Jacobus Susan N H , Dondokambey Clay J H , Sauyai Stanly F M , Qowi Moh. , Kalesaran Renaldy J
Published: March 2024

Technology in the field of education can now be utilized with the aim of solving various existing problems, including students' learning problems at school. The aim of this research is to develop interactive learning media in network service technology subjects at Christian Vocational School 1 Tomohon as a tool in the learning process. The development method used is the Multimedia Development Life Cycle (MDLC) method. This development method consists of 6 stages, namely: (1) Concept, (2) Design, (3) Material Collecting, (4) Assembly, (5) Testing, (6) Distribution. This learning media testing includes 3 tests, namely compatibility testing by media experts, material suitability testing by material experts, and usability testing by users. Making this learning media itself uses the Adobe Animate application. From the tests that have been carried out, the results show that interactive learning media in the network service technology subject at Christian Vocational School 1 Tomohon has no problems and is suitable for use as a tool for students and teachers in the learning process.
Implementation of the Occupational Safety and Health Management System in the Automotive Light Vehicle Engineering Workshop of Cokroaminoto Vocational School, Kotamobagu
Authors: Sanusi Fadli M. , Rompas Parabelem Tinno Dolf , Oroh Rolly Robert
Published: March 2024

This research aims to determine the implementation of the Occupational Safety and Health (K3) management system in the Light Vehicle Engineering Automotive Workshop at Cokroaminoto Vocational School, Kotamonagu, which is based on the Occupational Safety and Health Management System. This research is a quantitative descriptive research. The research subjects were 3 respondents, namely 1 Head of Department, 1 Workshop Coordinator, and 1 Technician. Data was collected using a questionnaire and cross-checked with documentation and interviews. Testing the validity of the instrument is carried out through expert judgment. Data analysis is presented in the form of block graphs and presented briefly in tables in the form of percentages of achievement scores which are then categorized and described based on the sub-indicators. Based on the research results, the achievement of indicators in the implementation of the Occupational Health and Safety Management System in the Automotive Workshop for Light Vehicle Engineering at Cokroaminoto Vocational School, Kotamonagu, namely 73.57% achieved, falls into the sufficient category, because the implementation of K3 has been achieved sufficiently, so it is necessary to increase the implementation of K3 following the K3 management system. The obstacles that influence the implementation of SMK3 are the lack of awareness among students about the importance of K3, the absence of a special team that handles K3 at the Light Vehicle Engineering Automotive Workshop at SMK Cokroaminoto Kotamonagu and the lack of documentation at the Light Vehicle Engineering Automotive Workshop at SMK Cokroaminoto Kotamonagu. Efforts made to overcome obstacles are by providing direction and advice to students about the importance of K3 and students are advised to always use PPE when practicing. The need for a special team that handles K3 and documentation related to K3 must be improved so that the implementation of K3 in Automotive Workshops is run by regulations and legislation. When using tools, students must take part in maintaining and maintaining them so that the tools are not easily damaged and it is necessary to replace tools if one is damaged and add additional tools so that students do not have to take turns using the tools.
The Influence of The Project-Based Learning Model on the Poetry Writing Skills of Class V Students of Pineleng State Elementary School
Authors: Monigir Norma
Published: March 2024

This research aims to improve poetry writing skills using the Project-based Learning Model for Class V Students of Pineleng State Elementary School. This research method uses quantitative research with the type of research being experimental research. This research was carried out to improve poetry writing skills using the Project Based Learning Model. The results of this research show that there is an influence of the use of project-based learning on learning outcomes for poetry writing skills, in line with the results of observations made. Based on the results of observations, there were changes in students where at the beginning of learning activities there were several students who were doing other activities or acting indifferent during the learning process. Observation results show that there are a large number of students who answer when asked questions and students who volunteer to work on questions on the blackboard. Students also begin to be active and confident in responding to answers from other students so that other students are also motivated to follow the lesson.
The Influence of Field Work Practical Experience and Motivation to Enter the Industrial World on the Work Readiness of Class XII Students at Vocational School State 1 Ratahan Southeast Minahasa Regency
Authors: Kuhu Maikel Wolter , Rompas Parabelem Tinno Dolf , Olii Djami
Published: March 2024

This research aims to determine the influence of practical fieldwork experience and motivation to enter the world of work on the work readiness of class XII students at SMK Negeri 1 Ratahan Kab. Southeast Minahasa. The population in this study was all class The type of research contained in this research uses quantitative research. data collection techniques using questionnaires. Data processing uses inferential analysis techniques, Multiple Linear Regression Analysis; Regression Line analysis of variance; classical assumption test, Multicollinearity Test, Heteroscedasticity Test, Normality; F test, and t test with the help of the IBM SPSS program for Windows 25.0. The results of the research show that the general description of the experience of fieldwork practice and motivation for entering the world of work on the work readiness of class XII students at SMK Negeri 1 Ratahan is included in the high category. Fieldwork practice experience and motivation to enter the world of work influence students' work readiness by 57.3%. This research concludes that there is a positive and significant influence between practical fieldwork experience and motivation to enter the world of work on students' work readiness, both partially and simultaneously.
Vocational Education Management: Multi-Case Study at SMK Center of Excellence Bitung City, Manado City, Tomohon City North Sulawesi Province
Authors: Punuh Grace , Katuuk Deitje Adolfien , Rawis Joulanda A.M. , Rotty Viktory Nicodemus Joufree
Published: March 2024

The research in this dissertation is motivated by a phenomenon where there are still various challenges in the development and efforts to advance Vocational High Schools which include: the still high unemployment rate for Vocational High School graduates, and incomplete integration between Vocational High Schools and the industrial world/world of work such as: development curriculum, learning process, learning evaluation, to graduate marketing. The focus of the research in writing this thesis is: 1) How is Vocational Education Planning at Christian Vocational School 2 Tomohon, SMKN 2 Bitung and SMKN 1 Manado? 2) What is the Implementation of Vocational Education at Christian Vocational Schools 2 Tomohon, SMKN 2 Bitung and SMKN 1 Manado? 3) How is the Monitoring and Evaluation (Monev) of Vocational Education at Christian Vocational Schools 2 Tomohon, SMKN 2 Bitung and SMKN 1 Manado? This type of research is a qualitative descriptive study using a multi-case approach, data collection techniques 1) Participant Observation, 2) In-depth interviews, 3) Documentation, 4) FGD (Focus Group Discussion), and data analysis with the approach of (1) analysis of individual case data, and (2) cross-case analysis of data. From the results of this study, the authors conclude that: 1) Vocational Education Planning: the principal prepares the documents needed for registration SMK-PK and forms an SMK-PK team and a development team involving related stakeholders. 2) Implementation of Vocational Education: The implementation of the SMK-PK program starts in 2021 which is SMK-PK in the first stage the school gets assistance in the form of physical equipment, while in the second stage, it focuses on the program. The principal participates in every program or activity carried out such as collaboration with du/di, participates in the process of teaching and learning activities, and so on. 3) Monitoring and Evaluation (Monev) of Vocational Education: The school principal conducts internal evaluations related to the curriculum program and management of SMK-PK. The Principal also evaluates the learning process by controlling the implementation of the learning process. In the management of SMK-PK, there is also an evaluation in the form of control carried out by the government on the management of SMK PK funds so that schools must report regarding the progress of program implementation and the use of SMK-PK funds.
The Influence of School Principal Leadership, Family Environment, and Learning Motivation on Student Learning Outcomes at State Junior High School 1 and 3 Tareran
Authors: Rumengan Meylan Meyti , Wullur Mozes Markus , Lengkong Jeffry Sony Junus
Published: March 2024

Student learning outcomes are the main problem in this research. This research aims to analyze the influence of the principal's leadership, family environment, and learning motivation on student learning outcomes at State Junior High School 1 and 3 Tareran. This type of research uses a survey research method with a quantitative research approach and is analyzed using descriptive data analysis as well as percentages and multiple linear regression. The research population was 283 respondents and the sample was 57 respondents using probability sampling techniques. The data collection technique used consists of distributing questionnaires and documentation of student learning outcomes. The results of the analysis show that there is a significant and positive influence between the variables of principal leadership, family environment, and learning motivation on student learning outcomes in the two secondary schools. The family environment variable has the greatest influence at 20.25%, followed by the principal's leadership at 12.39%. and learning motivation of 7.29%.
The Influence of Human Capital, Relational Capital, Organizational Capital, and the Information Technology Utilization on the ASN Performance in the Regional Social Services of the North Sulawesi Province Government
Authors: Mangli Lili , Dotulong Lucky O.H. , Lumintang Genita G.
Published: March 2024

The Social Service is the technical implementing element of Regional Government in the social sector which is tasked with carrying out regional autonomy authority in the field of social welfare services so that good performance is very much needed. Data collection in this research involved all ASNs at the Regional Social Service of North Sulawesi Province as respondents, namely 144 people. This research aims to analyze the influence of Human Capital, Relational Capital, Organizational Capital, and the Use of Information Technology on the performance of ASN of the Regional Social Service of North Sulawesi Province. The results of this research are (1) Human Capital has a positive and significant effect on ASN Performance at the North Sulawesi Province Regional Social Service (2) Relational Capital has a positive and significant effect on ASN Performance at the North Sulawesi Province Regional Social Service (3) Organizational Capital has a positive and significant effect significant impact on the performance of ASN in the Regional Social Service of North Sulawesi Province (4) Utilization of IT has a positive and significant effect on ASN Performance in the Regional Social Service of North Sulawesi Province (5) Human Capital, Relational Capital, Organizational Capital, and Utilization of IT together have an influence significant impact on the performance of ASN at the Regional Social Service of North Sulawesi Province.
Perancangan Sistem Informasi Buku Tamu Pada Website Kantor Pencarian Dan Pertolongan Kelas A Medan
Authors: Yanti Fitri rahya , Br Purba Yunita dana yanti , Santoso Heri
Published: March 2024

Abstract

The Medan Class A Search and Rescue Office is a government agency whose main task is to carry out rescue, search and rescue operations. This agency is also a bridge for coordination with other agencies to improve the evacuation process in certain circumstances. An agency visit often occurs to this agency. Visitors or guests are often recorded in a special agenda or book which is recorded conventionally. This condition is certainly less effective because recording is still carried out using physical books which are easily damaged and often cause queues when guests register themselves. After knowing this problem, the author designed a guest book information system which was intended to fill in the features on the Medan Class A Search and Relief Office website. The goal is to fill in guest data more neatly and not cause data loss or damage. The method used in this research is the waterfall method, this method has its own specifications, so that a system can be developed according to what is desired. The way this method works is systematically and gradually so that all information and results will be recorded well and distributed accurately and quickly. The system was built using the PHP programming language with MySQL as the database.
Rancang Bangun Sistem Informasi Penerimaan Siswa Baru Berbasis Web
Authors: Fadhli Erlangga Lubis Bayu , Nurul Amanda Khairani Lubis  , Dwi Tyas Nurul Lita  , Friska Andriani  , Annisatul Padlah
Published: March 2024

Kemajuan teknologi baru-baru ini berkembang sangat cepat serta dapat menjawab tantangan dan hambatan. Salah satu bentuk pemanfaatan teknologi dapat digunakan dalam bidang Pendidikan dengan menggunakan Sistem Informasi Berbasis web dalam penerimaan siswa baru. SMA Swasta Prayatna Medan merupakan  Sekolah Menegah Atas Swasta yang memiliki 2 jurusan yaitu IPA dan IPS.SMA Prayatna Medan setiap tahunnya membuka pendaftaran siswa baru,SMA Swasta Prayatna Medan masih melakukan sistem manual yaitu mencatat semua nama nama siswa yang ingin mendaftar menggunakan  buku dan fomulir pendaftaran dan menyimpan berkas nya di dalam lemari.Hal ini menjadikan para pihak sekolah kesulitan dalam mengelolah data yang setiap waktunya akan berubah terus menerus.Solusi dari permasalahan yang terjadi di SMA Prayatna Medan adalah membangun Sistem Informasi  Penerimaan Siswa Baru Berbasis Web di SMA Prayatna. Sistem ini dikembangkan menggunakan bahasa pemrograman PHP Native dengan menggunakan Framework bosstrap dan MysSql sebagai database. Metode yang digunakan dalam membangun sistem ini adalah menggunakan metode waterfall. Sistem ini diharapkan dapat mempermudah dan mempercepat proses pengelolaan data calon siswa baru.
Der vil komme en dag, eller den vil nok ikke komme
Authors: Borchert Anne Mari
Published: March 2024

In Ingeborg Bachmann’s Malina, the I ends up disappearing into the wall of her apartment. The ending points to gendered aspects of the novel and is also significant in a historical context. In a lecture, Bachmann states that whereas the I used to be situated in history, history has recently situated itself in the I. This statement is dealt with at length in order to connect the ending with questions of gender and historiography in the novel.
Slutspil
Authors: Rye Andersen Tore
Published: March 2024

The article begins with a close reading of the concluding passage of Cormac McCarthy’s novel The Road (2006), which depicts a postcatastrophic and anthropocentic scenario where the planet is destroyed beyond repair. The article then analyzes the rest of The Road, which on several levels is a novel about endings, and in dialogue with theories by for instance Frank Kermode, Peter Brooks, J. Hillis Miller and Marianna Torgovnick, it concludes by discussing McCarthy’s predilection for double endings, where the conclusion of the plot and the conclusion of the novel are not the same.
I trettende time
Authors: Schatz-Jakobsen Claus
Published: March 2024

Anmeldelse af: Marianne Barlyng (red.): Solen er ligeglad – er litteraturen?, Forlaget Spring, 2022.
Hvad er litteratursociologi?
Authors: Tanderup Linkis Sara , Gormsen Schmidt Johanne
Published: March 2024

Since its heyday in the 1960 and 70s, the sociology of literature has been declared dead and gone, yet research related to the field also seems to be reemerging in the first decades of the 21st century. Research relating to the field is scattered across other disciplines, such as literary studies, media studies and cultural studies; indeed, sociology of literature is “everywhere and nowhere”, as James English put it in 2010. But where is it now? Departing from recent perspectives on the sociology of literature by e.g. English, Wendy Griswold, and Johan Svedjedal, the article traces a brief history of the field and discusses future directions for the sociology of literature relating to current trends in literary studies and studies in book culture – including a recent attention towards uses of literature and methodological developments linked to digital methods as well as media-specific analysis and intermedial approaches to books and literature.
Litterär Kvinnokamp, anno 2014
Authors: Janson Oscar
Published: March 2024

This article examines the functions of feminism in the critical reception of Kristina Sandberg’s Maj-Trilogy, published 2010-2014. Detailing the evaluative patterns of reviews, it is shown that critics’ increased attention to feminist politics and women’s history in the novels was tied to a de-aestheticizing rhetoric, exemplifying gender hierarchies on the literary field. However, the trilogy’s critical and commercial success is also shown to be based on conception of the women’s cause and feminist writing traditions. Connecting these points, the article argues that a principal function of feminism on the contemporary Swedish book market is to make varying evaluative principles visible, and to bridge the boundaries of cultural, political and social fields.
Når litteraturfestivalen finner sted
Authors: Oterholm Knut , Vold Tonje
Published: March 2024

The article presents a qualitative analyses of three Norwegian literary festivals (Litteratursymposiet in Odda, Bergen International Literary Festival and Norsk Litteraturfestival Sigrid Undset-dagene). The analyses build on interviews with central actors of the festivals and participating observations at the festivals, during 2021 and 2022. We discuss what traditions the festivals build on, and take particular interest in the varied ways these three festivals build communities in the post-pandemics period, interact with their host cities and with their audiences, and discuss how the festivals’ centripetal and centrifugal forces are in play.
"S¨å hang den bare ned!"
Authors: Frostholm Peter Hornbæk , Krøyer Thomas Rauff
Published: March 2024

Denne artikel tager sit udspring i et tre måneder langt etnografisk feltarbejde på et togværksted. Her arbejder over 400 medarbejdere, herunder dieselmekanikere, smede og elektrikere – næsten alle er mænd. Det, de fleste af dem har til fælles, er, at de har været på værkstedet i lang tid – flere i 25-30 år og mere. Værkstedet bærer en historicitet og arv, der viser sig central for kulturen og de sociale forståelser blandt mændene, da de sammen opbygger og dyrker den. Gennem udvalgte empiriske fund fra projektets datamateriale viser denne artikel, hvordan flere mænd på værkstedet producerer mytelignende beretninger om tidligere og nuværende medarbejdere gennem særlige fortællinger og gennem brugen af øgenavne, drillerier og præstationer og skaber mytologiske repræsentationer af stedet og dets mænd.
Enquete: Nordatlantens autopia
Authors: Gaini Firouz
Published: March 2024

Enquete: Nordatlantens autopia
Doktorens bord: Maveproblemer
Authors: Larsen Camilla Brændstrup
Published: March 2024

Doktorens bord: Maveproblemer - Irritation, eksperimenteren og velfærd i Danmark
Mindeord: Oscar Salemink
Authors: Gammeltoft Tine
Published: March 2024

Mindeord: Oscar Salemink
Gamle og kommende numre
Authors: Temaredaktionen
Published: March 2024

Gamle og kommende numre
Danske resuméer
Authors: Temaredaktionen
Published: March 2024

Danske resuméer
Enquete: Christiania - Et mytisk sted?
Authors: Pedersen Jiesper Strandsbjerg Tristan
Published: March 2024

Enquete: Christiania - Et mytisk sted?
The Court of Justice Kicks Around the Dichotomy Between Data Protection and Competition Law Case Comment of the Preliminary Ruling in Case C-252/21 Meta Platforms v. Bundeskartellamt
Authors:   University Carlos III of Madrid, Ribera Martínez Alba
Published: March 2024

Data protection and competition law have been at a crossroads in terms of their integration. Antitrust authorities as well as data protection supervisory authorities have grappled with the question of whether both fields of law should be combined into the same analysis. The German competition authority, the Bundeskartellamt, was the first to fuse them in its landmark case against Facebook’s data processing terms and conditions. The exploitative theory of harm put forward by the German NCA is the first of its kind to integrate data protection considerations into the antitrust analysis, namely by drawing a line between an infringement with the General Data Protection Regulation (GDPR) and anti-competitive harm. This case comment outlines its key developments at the national level, to then address the questions that have been answered by the Court of Justice of the European Union, CJEU, in Case C-252/21 concerning the interpretation of the GDPR in the context of competition law.
Gut microbiota-derived gamma-aminobutyric acid from metformin treatment reduces hepatic ischemia/reperfusion injury through inhibiting ferroptosis
Authors: Wang Fangyan , Liu Xiujie , Huang Furong , Zhou Yan , Wang Xinyu , Song Zhengyang , Wang Sisi , Wang Xiaoting , Shi Dibang , Ruan Gaoyi , Ji Xiawei , Zhang Eryao , Tan Zenglin , Ye Yuqing , Wang Chuang , Zhu Jesse , Wang Wantie
Published: March 2024

Hepatic ischemia/reperfusion injury (HIRI) is a common and inevitable factor leading to poor prognosis in various liver diseases, making the outcomes of current treatments in clinic unsatisfactory. Metformin has been demonstrated to be beneficial to alleviate HIRI in recent studies, however, the underpinning mechanism remains unclear. In this study, we found metformin mitigates HIRI-induced ferroptosis through reshaped gut microbiota in mice, which was confirmed by the results of fecal microbiota transplantation treatment but showed the elimination of the beneficial effects when gut bacteria were depleted using antibiotics. Detailedly, through 16S rRNA and metagenomic sequencing, we identified that the metformin-reshaped microbiota was characterized by the increase of gamma-aminobutyric acid (GABA) producing bacteria. This increase was further confirmed by the elevation of GABA synthesis key enzymes, glutamic acid decarboxylase and putrescine aminotransferase, in gut microbes of metformin-treated mice and healthy volunteers. Furthermore, the benefit of GABA against HIRI-induced ferroptosis was demonstrated in GABA-treated mice. Collectively, our data indicate that metformin can mitigate HIRI-induced ferroptosis by reshaped gut microbiota, with GABA identified as a key metabolite.
Comparative neuroimaging of sex differences in human and mouse brain anatomy
Authors: Guma Elisa , Beauchamp Antoine , Liu Siyuan , Levitis Elizabeth , Ellegood Jacob , Pham Linh , Mars Rogier B , Raznahan Armin , Lerch Jason P
Published: March 2024

In vivo neuroimaging studies have established several reproducible volumetric sex differences in the human brain, but the causes of such differences are hard to parse. While mouse models are useful for understanding the cellular and mechanistic bases of sex-specific brain development, there have been no attempts to formally compare human and mouse neuroanatomical sex differences to ascertain how well they translate. Addressing this question would shed critical light on the use of the mouse as a translational model for sex differences in the human brain and provide insights into the degree to which sex differences in brain volume are conserved across mammals. Here, we use structural magnetic resonance imaging to conduct the first comparative neuroimaging study of sex-specific neuroanatomy of the human and mouse brain. In line with previous findings, we observe that in humans, males have significantly larger and more variable total brain volume; these sex differences are not mirrored in mice. After controlling for total brain volume, we observe modest cross-species congruence in the volumetric effect size of sex across 60 homologous regions (r=0.30). This cross-species congruence is greater in the cortex (r=0.33) than non-cortex (r=0.16). By incorporating regional measures of gene expression in both species, we reveal that cortical regions with greater cross-species congruence in volumetric sex differences also show greater cross-species congruence in the expression profile of 2835 homologous genes. This phenomenon differentiates primary sensory regions with high congruence of sex effects and gene expression from limbic cortices where congruence in both these features was weaker between species. These findings help identify aspects of sex-biased brain anatomy present in mice that are retained, lost, or inverted in humans. More broadly, our work provides an empirical basis for targeting mechanistic studies of sex-specific brain development in mice to brain regions that best echo sex-specific brain development in humans.
Open-top Bessel beam two-photon light sheet microscopy for three-dimensional pathology
Authors: Park Won Yeong , Yun Jieun , Shin Jinho , Oh Byung Ho , Yoon Gilsuk , Hong Seung-Mo , Kim Ki Hean
Published: March 2024

Nondestructive pathology based on three-dimensional (3D) optical microscopy holds promise as a complement to traditional destructive hematoxylin and eosin (H&E) stained slide-based pathology by providing cellular information in high throughput manner. However, conventional techniques provided superficial information only due to shallow imaging depths. Herein, we developed open-top two-photon light sheet microscopy (OT-TP-LSM) for intraoperative 3D pathology. An extended depth of field two-photon excitation light sheet was generated by scanning a nondiffractive Bessel beam, and selective planar imaging was conducted with cameras at 400 frames/s max during the lateral translation of tissue specimens. Intrinsic second harmonic generation was collected for additional extracellular matrix (ECM) visualization. OT-TP-LSM was tested in various human cancer specimens including skin, pancreas, and prostate. High imaging depths were achieved owing to long excitation wavelengths and long wavelength fluorophores. 3D visualization of both cells and ECM enhanced the ability of cancer detection. Furthermore, an unsupervised deep learning network was employed for the style transfer of OT-TP-LSM images to virtual H&E images. The virtual H&E images exhibited comparable histological characteristics to real ones. OT-TP-LSM may have the potential for histopathological examination in surgical and biopsy applications by rapidly providing 3D information.
The voyage is as important as the harbor
Authors: Sabantsev Anton , Deindl Sebastian
Published: March 2024

To find nucleosomes, chromatin remodelers slide and hop along DNA, and their direction of approach affects the direction that nucleosomes slide in.
Resting heart rate and risk of dementia: a Mendelian randomization study in the international genomics of Alzheimer’s Project and UK Biobank
Authors: Chen Xingxing , Zheng Yi , Wang Jun , Yue Blake , Zhang Xian , Nakai Kenta , Yan Lijing L.
Published: March 2024

Background

Observational studies have demonstrated that a higher resting heart rate (RHR) is associated with an increased risk of dementia. However, it is not clear whether the association is causal. This study aimed to determine the causal effects of higher genetically predicted RHR on the risk of dementia.

Methods

We performed a two-sample Mendelian randomization analysis to investigate the causal effect of higher genetically predicted RHR on Alzheimer’s disease (AD) using summary statistics from genome-wide association studies. The generalized summary Mendelian randomization (GSMR) analysis was used to analyze the corresponding effects of RHR on following different outcomes: 1) diagnosis of AD (International Genomics of Alzheimer’s Project), 2) family history (maternal and paternal) of AD from UK Biobank, 3) combined meta-analysis including these three GWAS results. Further analyses were conducted to determine the possibility of reverse causal association by adjusting for RHR modifying medication.

Results

The results of GSMR showed no significant causal effect of higher genetically predicted RHR on the risk of AD (βGSMR = 0.12, P = 0.30). GSMR applied to the maternal family history of AD (βGSMR = −0.18, P = 0.13) and to the paternal family history of AD (βGSMR = −0.14, P = 0.39) showed the same results. Furthermore, the results were robust after adjusting for RHR modifying drugs (βGSMR = −0.03, P = 0.72).

Conclusion

Our study did not find any evidence that supports a causal effect of RHR on dementia. Previous observational associations between RHR and dementia are likely attributed to the correlation between RHR and other cardiovascular diseases.
The impact of FASTQ and alignment read order on structural variant calling from long-read sequencing data
Authors: Lesack Kyle J. , Wasmuth James D.
Published: March 2024

Background

Structural variant (SV) calling from DNA sequencing data has been challenging due to several factors, including the ambiguity of short-read alignments, multiple complex SVs in the same genomic region, and the lack of “truth” datasets for benchmarking. Additionally, caller choice, parameter settings, and alignment method are known to affect SV calling. However, the impact of FASTQ read order on SV calling has not been explored for long-read data.

Results

Here, we used PacBio DNA sequencing data from 15 Caenorhabditis elegans strains and four Arabidopsis thaliana ecotypes to evaluate the sensitivity of different SV callers on FASTQ read order. Comparisons of variant call format files generated from the original and permutated FASTQ files demonstrated that the order of input data affected the SVs predicted by each caller. In particular, pbsv was highly sensitive to the order of the input data, especially at the highest depths where over 70% of the SV calls generated from pairs of differently ordered FASTQ files were in disagreement. These demonstrate that read order sensitivity is a complex, multifactorial process, as the differences observed both within and between species varied considerably according to the specific combination of aligner, SV caller, and sequencing depth. In addition to the SV callers being sensitive to the input data order, the SAMtools alignment sorting algorithm was identified as a source of variability following read order randomization.

Conclusion

The results of this study highlight the sensitivity of SV calling on the order of reads encoded in FASTQ files, which has not been recognized in long-read approaches. These findings have implications for the replication of SV studies and the development of consistent SV calling protocols. Our study suggests that researchers should pay attention to the input order sensitivity of read alignment sorting methods when analyzing long-read sequencing data for SV calling, as mitigating a source of variability could facilitate future replication work. These results also raise important questions surrounding the relationship between SV caller read order sensitivity and tool performance. Therefore, tool developers should also consider input order sensitivity as a potential source of variability during the development and benchmarking of new and improved methods for SV calling.
Game Intention Analysis and Optimal Decision Methods: A Survey
Authors: Zhu Zeyu
Published: March 2024

This paper provides a comprehensive review of the research on intention analysis and optimal decision-making methods for group games in the field of air combat. Air combat is considered as a complex game process involving multiple participants, stages, and incomplete information. It encompasses three key aspects: intention analysis, mission planning, and autonomous decision-making. The paper presents an overview of the principles, methodologies, and applications related to intention representation and recognition methods, competition and cooperation models, as well as optimal decision generation algorithms in group games. Furthermore, future research directions are proposed including the integration of optimization algorithms with learning algorithms, exploration of large-scale optimization techniques, and investigation into leveraging deep learning approaches for modeling, prediction, and optimization in crowd games.
La licencia de propiedad industrial: entre la infracción y el incumplimiento. El caso español
Authors: Carreño Mendoza Sergio
Published: March 2024

El contrato de licencia ha ganado preponderancia en el tráfico jurídico por la capacidad que tiene para integrar los bienes inmateriales en los procesos de producción y/o de comercialización de productos y servicios. El titular no puede quedar en peor condición con la suscripción del contrato y, como mínimo, debería ser neutral frente a la eficacia jurí- dico-real de la propiedad industrial. En determinados contextos, los remedios contractuales resultan insuficientes para garantizar la aludida eficacia porque dejan en manos del licenciata- rio la posibilidad de hacerse con derechos adicionales a los inicialmente otorgados por la vía del incumplimiento. Frente a la disyuntiva, el legislador español (inspirado en el derecho co- munitario) ha establecido las materias que permiten el ejercicio del ius prohibendi. Intuitiva- mente podría pensarse que el titular preferirá las acciones de infracción porque ofrecen mejor protección de su titularidad, pero, como se verá en el presente trabajo, no es infrecuente que el titular opte por los remedios contractuales.
A expansão de cursos de graduação a distância na Universidade Federal do Pará, no período de 2007-2017
Authors: Ribeiro Maria Edilene da Silva , Silva Eliomar Nascimento da
Published: March 2024

O artigo intitulado "A expansão de cursos de graduação a distância na Universidade Federal do Pará, no período de 2007-2017" teve como objetivo analisar a expansão dos cursos de graduação a distância na UFPA, com destaque para o Curso de Licenciatura em Matemática, no período 2007 a 2017. Trata-se de uma pesquisa qualitativa com estudo de caso. Autores como Malanchen (2007, 2015), Giolo (2010), Machado (2006), Castro (2005, 2009), entre outros contribuíram para o arcabouço teórico que fundamentou a análise documental. Nas considerações finais ressalta-se que a oferta de cursos EaD segue a lógica neoliberal impregnada na reforma do Estado brasileiro e na Educação Superior. Como resultado, a pesquisa mostrou que a Educação a Distância na UFPA apresenta características semelhantes a observada no cenário nacional, com tendência a ampliação do acesso, sem garantia da permanência e com alto índice de evasão, levando-nos a acreditar que esta modalidade de ensino ainda está distante de se apresentar como alternativa capaz de promover a democratização do ensino superior na região.
Spectrum of Unusual Cytomorphology of Axillary Swellings: A Series of Four Cases
Authors: Adhlakha Paridhi, Bhuvan , Kalhan Shivani , Shukla Shalini , Gupta Vivek
Published: March 2024

The axilla is a triangular area situated anatomically beneath the shoulder joint, between the upper arm and thorax. It contains lymph nodes and numerous non lymphatic tissues such as neurovascular structures, muscle, and fat. Axillary swellings can arise from any of these mesenchymal soft tissues. Fine Needle Aspiration Cytology (FNAC) is the first-line investigative technique widely used in evaluating axillary swellings, as it is a simple outpatient procedure that causes minimal complications, unlike core biopsy, which is invasive and carries a high-risk of bleeding. Hereby, the authors present a case series of four unusual cases: bilateral accessory breast tissue (32-year-old female), bilateral galactocele (28-year-old female), unilateral galactocele (24-year-old female), and fibroadenoma (35-year-old female) in the axilla, all of which were cytomorphologically diagnosed with the aid of FNAC. Axillary lumps can present with a variety of unusual lesions and can pose a significant diagnostic challenge to a clinicians. Although histopathology of the biopsy of the lesion remains the gold standard, clinical features along with imaging can aid in the diagnosis with better patient compliance.