bluuebunny/crossref_metadata_2025 huggingface dataset:
Lessons from Large-Scale Tolerability and Acceptability Studies of Triple Drug Mass Drug Administration Performed to Support Policy Change and Accelerate Elimination of Lymphatic Filariasis
Authors: Weil Gary J. , Fischer Peter U. , Krentel Alison
Published: March 2022

Early clinical trials clearly demonstrated the superior efficacy of triple drug therapy with ivermectin plus DEC and albendazole (IDA) for clearing microfilaremia (Mf) in individuals with lymphatic filariasis (LF). Although these initial pharmacokinetic and efficacy studies were necessary first steps in the clinical development of IDA, they were not sufficient to justify policy changes necessary for widespread use of this new regimen by national filariasis elimination programs. Processes and procedures that led to the World Health Organization’s (WHO) endorsement of IDA as a mass drug administration (MDA) regimen for LF are reviewed elsewhere in this supplement. However, the “guideline review process” depended heavily on preliminary results from multicenter studies that were performed to compare the safety, tolerability, and acceptability of IDA versus DA (the two-drug regimen of DEC plus albendazole that was recommended for use for filariasis elimination in countries without co-endemic onchocerciasis or loiasis). Efficacy and tolerability results from those studies have been recently published. Therefore, this paper will focus on practical aspects of the planning and conduct of the large-scale studies that were so critically important for policy change.
Introduction of Triple-Drug Therapy for Accelerating Lymphatic Filariasis Elimination in India: Lessons Learned
Authors: Tripathi Bhupendra , Roy Nupur , Dhingra Neeraj
Published: March 2022

There are 670 million people at risk of contracting lymphatic filariasis (LF) in India, which bears 40% of the global burden of the disease. The National Program to Eliminate LF was launched in 2004 first with a single-drug therapy—diethylcarbamazine (DEC), followed by a two-drug therapy—DEC + albendazole (DA). In 2017, following successful drug trials, World Health Organization endorsed a new triple-drug therapy to fight LF using ivermectin with DEC and albendazole (IDA).1 In June 2018, India made new commitments to accelerate their program to eliminate LF and initiated the new IDA protocol in five districts in the country. This article looks at the experience of India in the roll out of the new drug protocol and shares their preparations, successes, challenges, and lessons learned.
Lessons Learned from the Japanese Encephalitis Vaccine Introduction in India That Supported the Introduction of Ivermectin–Diethylcarbamazine–Albendazole for Lymphatic Filariasis Elimination
Authors: Ghosh Raj Shankar , Haldar Pradeep , Jacobson Julie
Published: March 2022

We used the introduction of the Japanese encephalitis (JE) vaccine in India as an example to understand more fully the process of introducing any new clinical product in India. We discuss the key decision-making points as well as the many activities involved in introducing a new clinical product in India’s public health program. We write from our experience in supporting the government of India to introduce new products successfully—namely, vaccines—to India’s health system. In India, the process begins with identifying the public health problem (e.g., an outbreak of JE), deciding to take action, prioritizing where action is needed, securing a supply and price of the intervention (the vaccine; in this case, the live, attenuated SA 14-14-2 vaccine), and determining how to ensure effective rollout of the intervention (the vaccination program). Reflecting on the experience of the JE vaccination program helped to inform the introduction of the triple-drug therapy of ivermectin, diethylcarbamazine, and albendazole in India as a new treatment protocol for lymphatic filariasis.
Kalekie świadectwa. Niepełnosprawność i protesty w Polsce w 2018 i 2020 roku
Authors: Pamuła Natalia
Published: March 2022

Crip Testimonies: Disability and Protests in Poland in 2018 and 2020

Author uses the category of Robert McRuer’s “crip resistance” to think of two waves of disability related protests, which took place in Poland. In 2018 disabled people and their caregivers occupied the Parliament for 40 days to demand higher social security benefits and many people, including those without disabilities, took to the streets to support the protest. In 2020, the Polish Constitutional Tribunal prohibited abortion based on disability status, which caused anger among huge parts of Polish population, including women with disabilities. This article looks at disabled people’s statements made in 2018 in support of the interabled group occupying the Parliament and compares them with disabled women’s voices regarding recent introduction of the ban on abortion based on disability status. I call these five statements made by disabled people “crip testimonies” and analyze how Polish experiences of disability do not fit neatly within Western conceptions of disability developed within disability studies, most prominently, the social and the medical model of disability. In other words, this article pays attention to what is unique about Polish experiences of disability and makes a case for thinking about disability through people’s testimonies, not theories.
Korpomuzeum jako typ idealny
Authors: Żak-Szwarc Justyna
Published: March 2022

Corpomuseum as an Ideal Type The beginning of the 21st century was a time of great museum revolution. Many museums have been created that focus their activities not so much on collecting artefacts as on presenting impressive exhibitions, largely made of media relays. New museums are increasingly moving away from the concern for durable goods that characterizes traditional museums and transfer knowledge to their recipients through modern products and attractive technologies. In connection with the implementation of new and costly solutions regarding architecture, equipment, organizational structure and functioning, they actually need a lot of capital in the form of public finances and “human resources” from the very beginning of their activity. It seems that at present the need to raise this type of capital in a case of creating new institutions is far ahead of the need to collect works of culture that have constituted the essence and sense of museums created in previous centuries. The quality of planned projects also ceases to be related to the significance and reputation of the material culture heritage, and begins to be measured by the scale of the new museum buildings and the number of visitors. Products instead of cultural goods, or even products understood as cultural goods; visitors as engaged customers; capital understood by finance and “human resources”; large size ‒ which covers many issues ‒ ranging from structure, and architecture; modern technologies; political influence; brand strength and promotion ‒ all these aspects resemble the corporate model of organization. They provoke reflection on the functioning of the museum as a corporation, which is the purpose of the ideally typical structure of the “corpomuseum”.
Wiatr z Północy. Dyskursywne konstruowanie Heimat na przykładzie gmachu dawnej Królewskiej Szkoły Rzemiosł Budowlanych w Katowicach i jego wystroju
Authors: Gorzelik Jerzy
Published: March 2022

Wind from the North: The Discursive Construction of Heimat Exemplified by the Edifice of the Former Royal School of Building Crafts (Königliche Baugerwerkschule) in Katowice and its Decoration

The paper examines the edifice of the former school of building crafts (Baugewerkschule) in Katowice, Upper Silesia, which opened in 1901, and its decoration. The works of architecture, painting and sculpture were interpreted as carriers of a discourse calculated to construct Heimat, located within the borders of the Prussian Silesian Province. The building’s forms, reminiscent of the brick Gothic of northern Germany, were characteristic of the milieu of the Technische Hochschule in Hannover, where the designers of the edifice were educated. The city’s coat of arms was depicted on the facade, the vaulted ceiling of the auditorium was decorated with dragon and gryphon motifs of Scandinavian origin, and its walls painted with images of St. Hedwig ‒ the patron saint of Silesia, viewed here as a deconfessionalized personification of the land ‒ the Prussian eagle, and four iconic monuments of historic Silesian architecture. Thus, references were made to various levels of identity ‒ local, regional, national, and the mythologised Germanic North. The narrative constructed in this way fits into the cultural nationalism of the educated German bourgeoisie (Bildungsbürgertum), which grows out of the Romantic tradition. At the same time, the emphasis on the opposition of the North and South can be seen as a strategy for overcoming the peripheral status of Silesia in a world organised by the West-East axis. The school’s building in Katowice exemplifies how the elites of the German Empire used visual means to construct modern imagined communities.
Stefana Morawskiego wizja sztuki masowej i estetyzacji świata – uwagi krytyczne
Authors: Rogoziecki Robert
Published: March 2022

The text considers the concept of aestheticization and the influence of mass culture on it in the light of Stefan Morawski’s views. Morawski adopted a value-laden attitude towards mass art. That is why in his reflections on aestheticization processes its role remains unnoticed by him, contrary to his original declarations. This is why I have to ask Morawski questions that he leaves unanswered. Does in fact the spectacularity of contemporary life result in its “art-like” constitution? The author of the essay gives a positive answer here, stressing that mass art becomes the model for shaping life, and tries to answer what this pattern is based on. Thus Morawski’s views appear here as a negative point of reference. The positive part of the considerations, on the other hand, focuses on Walter Benjamin and Jean Baudrillard.
Density of Arithmetic Representations of Function Fields
Authors: Esnault Hélène , Kerz Moritz
Published: March 2022

We propose a conjecture on the density of arithmetic points in the deformation space of representations of the \'etale fundamental group in positive characteristic. This? conjecture has applications to \'etale cohomology theory, for example it implies a Hard Lefschetz conjecture. We prove the density conjecture in tame degree two for the curve $\mathbb{P}^1\setminus \{0,1,\infty\}$. v2: very small typos corrected.v3: final. Publication in Epiga.

Comment: 18 pages
A non-local model for the description of twinning in polycrystalline materials in the context of infinitesimal strains: application to a magnesium alloy
Authors: Mareau Charles , Abdolvand Hamidreza
Published: March 2022

A polycrystalline plasticity model, which incorporates the contribution of
deformation twinning, is proposed. For this purpose, each material point is
treated as a composite material consisting of a parent constituent and multiple
twin variants. In the constitutive equations, the twin volume fractions and
their spatial gradients are treated as external state variables to account for
the contribution of twin boundaries to free energy. The set of constitutive
relations is implemented in a spectral solver, which allows solving the
differential equations resulting from equilibrium and compatibility conditions.
The proposed model is then used to investigate the behavior of a AZ31 magnesium
alloy. For the investigated loading conditions, the mechanical behavior is
controlled by the joint contribution of basal slip and tensile twinning. Also,
according to the numerical results, the development of crystallographic
texture, morphological texture and internal stresses is consistent with the
experimental observations of the literature.
A computational homogenization framework with enhanced localization criterion for macroscopic cohesive failure in heterogeneous materials
Authors: Ke Lu , van Der Meer Frans
Published: March 2022

Computational homogenization allows to let the macroscopic constitutive behavior of materials emerge from microscale simulations without loss of generality with respect to microstructure and microscale constitutive response. Although computationally demanding, computational homogenization works very well for the hardening response of materials where the macroscopic stress and strain fields are smooth. However, in case of softening materials, when localization of deformation takes place, special care is needed to ensure objectivity of the method. In this paper, a generic multiscale computational homogenization approach for modeling onset and propagation of cracks in heterogeneous materials that is capable of considering various microscale mechanisms is presented. The common acoustic tensor bifurcation criterion is reinforced by an additional condition to help detect the localization mode more robustly. After the onset of macroscale localization, a key scale transition parameter is needed to translate the macroscopic displacement jump to an averaged strain over the micromodel domain. Then the macroscale crack is governed by a homogenized traction-separation relation evaluated from the underlying micromodel in which micro-failure accumulates. The scale transition parameter is studied for a range of different scenarios and endowed with a geometrical interpretation. Various numerical tests have been performed to confirm the objectivity and validity of the framework. The framework is generic in the sense that no assumptions on the microscale constitutive or kinematic representation of material failure are made in the scale transition. The framework is also highly compatible with the first order computational homogenization, which minimizes the additional complexity of adding macroscopic crack growth to the computational implementation.
BDD-Based Algorithm for SCC Decomposition of Edge-Coloured Graphs
Authors: Beneš Nikola , Brim Luboš , Pastva Samuel , Šafránek David
Published: March 2022

Edge-coloured directed graphs provide an essential structure for modelling
and analysis of complex systems arising in many scientific disciplines (e.g.
feature-oriented systems, gene regulatory networks, etc.). One of the
fundamental problems for edge-coloured graphs is the detection of strongly
connected components, or SCCs. The size of edge-coloured graphs appearing in
practice can be enormous both in the number of vertices and colours. The large
number of vertices prevents us from analysing such graphs using explicit SCC
detection algorithms, such as Tarjan's, which motivates the use of a symbolic
approach. However, the large number of colours also renders existing symbolic
SCC detection algorithms impractical. This paper proposes a novel algorithm
that symbolically computes all the monochromatic strongly connected components
of an edge-coloured graph. In the worst case, the algorithm performs $O(p \cdot
n \cdot log~n)$ symbolic steps, where $p$ is the number of colours and $n$ is
the number of vertices. We evaluate the algorithm using an experimental
implementation based on binary decision diagrams (BDDs). Specifically, we use
our implementation to explore the SCCs of a large collection of coloured graphs
(up to $2^{48}$) obtained from Boolean networks -- a modelling framework
commonly appearing in systems biology.
Academic Foundations of Global Economic Governance – an Assessment
Authors: Gabriela Sterian Maria
Published: March 2022

The concept of global economic governance can be used to describing the prevailing global order and the most appropriate way of redefining the actual economic system. This concept is interesting not only because of the growing literature and interest in finding a proper definition, but more in challenging the limits of traditional international relations theories to explain a world where the shape and the role of individual states is changing. Even if particular theoretical paradigms try to emphasize specific characteristics of global governance, no one has been able to capture the complexity of this subject. Thus, the conceptualization of global economic governance requires a combination of particular aspects of different theories, which are deficient independently speaking, but together they can explain power, order, norms and change in world order. Objectives: This paper provides a critical analysis of the theoretical literature on global governance, especially in what regards liberalism, realism and constructivism, considered to be major theories in defining international relations concepts. Each paradigm is analyzed according to the key themes in order to define the main aspects of global governance. Prior Work: It has been tried to emphasizing the concepts already developed by known researchers in the field. Approach: The approach is a more theoretic one done in a comparative manner with emphasis on results and future research. The critical method approach is done with qualitative results. Results: The key results are related to theoretical foundations of defining the paradigm of global governance, as well as presenting a comparative approach of the most important features. Implications: The implications are varied in terms of studying the concepts and addresses researchers in the field, but also lecturers and students. Value: The main added value is the critical and subjective analysis of international relations’ economic theories in terms of defining the paradigm of global economic governance.
Penghargaan pada Kerja Tangan dalam 1 Tesalonika 4:9-12
Authors: Alam Bonifasius Pradipta Putra
Published: March 2022

In his first letter to the Thessalonians, Paul wrote three main problems based on Timothy’s reports (1Thess 3:6). For the second problem, Paul discusses it with the technique of captatio benevolentiae. Paul first commended the Thessalonian way of life. For Paul, the Thessalonians had retained a distinctive Christian virtue, namely φιλαδελφία. Paul wrote the proof, “And indeed ye do it toward all the brethren which are in all Macedonia” (1Thess 4:10). Out of praise, Paul later turned his letter into exhortation. Paul asked the Thessalonians “to be quiet, and to do your own business, and to work with your own hands” (1Thess 4:11). By using social and lexical approaches in interpreting 1 Thess 4:9-12, the writer finds the main focus of the second problem. Paul actually wanted to direct his advice to few Thessalonians who were able to work but chose not to work and instead depended on others. Paul refers to them as ἀτάκτοι. For Paul, they had damaged the reputation of the church in the eyes of τοὺς ἔξω by being a parasite and a burden to the rest of the Thessalonians.
Patrimonio cultural, protección jurídica y turismo en el Valle de Teotihuacán
Authors: Ortega Cabrera Verónica , Esquivel Rios Susana , González Corona Norma Lizbet
Published: March 2022

El Valle de Teotihuacán alberga uno de los yacimientos arqueológicos más importantes del mundo, además de un complejo paisaje cultural. La exploración de sus monumentos más prominentes y la apertura de la zona arqueológica, han generado un extraordinario nicho para el turismo cultural en el centro de México, cuya tendencia de crecimiento se ha incrementado conforme se integran nuevas ofertas y equipamientos turísticos. Sin embargo, la falta de diálogo entre los diversos actores sociales involucrados en estas actividades y la carencia de planes integrales que generen un turismo respetuoso, inclusivo y sustentable, podría poner en riesgo los principales atractivos, al generar acciones no concertadas e incluso, contrarias a las normas de protección del patrimonio cultural. Este trabajo revisa el estado que guarda la relación entre patrimonio cultural, marco normativo y turismo, estudiando un caso que resulta paradigmático para México y Latinoamérica, a través de una metodología cualitativa que nos permite identificar y describir las condiciones en que se han activado los recursos patrimoniales a lo largo del tiempo, así como las estrategias de gestión turística implementadas por diversos organismos de los tres niveles de gobierno y sus implicaciones en el contexto social, para establecer una propuesta de gestión turística del patrimonio desde la perspectiva integral.
How Multinational Corporations Can Support Refugee Workforce Integration: Empathize Globally, Strategize Locally
Authors: Szkudlarek Betina , Roy Priya , Lee Eun Su
Published: March 2022

In the global war for talent, refugees are often overlooked. Yet, research indicates that employers who expanded their recruitment strategies to include refugee jobseekers were not only satisfied with their new hires, but also excited about the potential impact refugee recruitment could have on their diversity, equity, and inclusion (DEI) strategies. We use the case of IKEA to show how localization and global strategy interact to create sustainable refugee workforce integration solutions for multinational corporations. Our insights have practical implications for other industry leaders who aim to create their own refugee inclusion programs.
Bankarski uslužni poslovi
Authors:   University of Kragujevac, Faculty of Law, Vujisić Dragan
Published: March 2022

The subject of this paper are banking transactions where the bank does certain services to third parties by the order of its client (banking services). Specifically, these are letter of credit (documentary and ordinary), bank guarantee and documentary bills for collection. These transactions include a couple of parties, three at least and they are the bank, orderer and user (of the letter of credit guarantee), but there may be a few banks as well. Special analysis is made of legal relationships between the participants in these transactions. These banking services are often used in international transactions (sale, others) and this fact then additionally makes their application complex (implying as a rule, participation of several banks having main offices in different countries). A special emphasis is also put on their role, the documentary letter of credit as a means of payment the bank guarantee as a means of securing but often it may be of multiple character (the documentary letter of credit may also have the function of means of funding and means of securing). In addition, all these services have similiraties to other legal activities (assurance, security, contract in favour of a third party contract on crediting and the like) but they are independent and autonomous legal activities.
OBAVEZNO OSIGURANjE VLASNIKA MOTORNIH VOZILA OD ODGOVORNOSTI ZA ŠTETU PRIČINjENU TREĆIM LICIMA
Authors:   University of Kragujevac, Faculty of Law, Miladinović Zoran
Published: March 2022

Motor vehicles no longer represent luxury goods, they are the means of satisfying vital human needs. However, as it often happens in life with many other objects, the use of motor vehicles also has its positive and negative effects. Due to the enormous power embodied in these machines, motor vehicles represent one of major risks for human lives. Not only the passengers are exposed to these hazards, by also the third parties, that is the persons outside the motor vehicles. Given this large discrepancy between the benefits of motor vehicles and the damages they cause, there have been many attempts in various fields aimed at mitigating the adverse effects of their use which cannot be completely eliminated. Thus in the field of law, there are a number of measures undertaken with the aim to prevent traffic accidents and reduce their negative effects. Taking into account that damages caused by motor vehicles mostly fall in domain of property law, a whole series of rules and provisions have been passed in order to regulate the issues such as in what cases and to what extent a motor vehicle insurance can cover damage claims in case of accidents involving motor vehicles. The compulsory motor vehicle insurance covering the liability of the vehicles owners in the event of incurring damages to third parties has become a very efficient method of reducing negative consequences of using motor vehicles. Establishing the legal relationship in domain of compulsory car insurance and its legal effect is regulated by imperative legal norms which protect the interests of persons participating in this legal relationship, but also the interests of wider social audience. In this paper the author analyzes the legal relationships established as a result of compulsory insurance imposed on the motor vehicle owners in the event of damages incurred by motor vehicles, the legal position of the insured and the insurer who, by receiving the insurance premium payments assume the responsibility to provide coverage for claims being made against the policy by all damage parties, including the damages incurred to third parties.
PRAVO DETETA NA USLUGE POVERLjIVOG SAVETOVANjA IZ DOMENA SEKSUALNOG I REPRODUKTIVNOG ZDRAVLjA
Authors:   University of Kragujevac, Faculty of Law, Vlašković Veljko
Published: March 2022

Adolescence is the final childhood stage, but extremely sensitive period. By entering puberty, widening social relationships and searching for the personal identity, a child has been rapidly gone through physical and psychological changes. Thus, transition to adulthood poses serious challenges, particularly in domains of sexual and reproductive health preservation and protection. Therefore, the right of a child to health includes also the application of the right to confidential medical counselling and advice in order to assist children so they can enjoy adequate level of sexual and reproductive autonomy in accordance with their evolving capacities and the best interests of the child. Although, confidential counselling service is provided primarily by adequate medical institutions, the obligation to provide children with information on sexual and reproductive health risks is much wider. Beside the parental duties regarding upbringing of children, it is highly important to introduce compulsory education on sexual and reproductive health in school curriculum. The UN Committee on the Rights of the Child recommended Serbia to develop comprehensive and ageappropriate education in this field which is necessary having in mind discouraging data on adolescent sexual and reproductive autonomy enjoyment in our society. Adolescents have the right to access to services of confidential counselling even without consent of their parents or legal representatives. However, the child’s best interests and their right to life, survival and development imply that parents must be provided with information in cases of serious dangers to life and health of the child.
Estimating the Impact of Corporate Science-based Emissions Targets on India’s Nationally Determined Contribution Goals
Authors: Gajjar Chirag , Chakrabarty Subrata , Shah Priyal
Published: March 2022

This paper, for the first time, analyses and presents the emission reduction potential of the Indian companies who have set science-based targets and highlight as to how it contributes to meeting the India’s NDC goals. The paper provides insights into the SBTs of 22 Indian companies who have adopted GHG emission reduction targets that are aligned with climate science.
A incidência dos sintomas de depressão pós-parto durante a pandemia de COVID-19
Authors: Gutierrez Sara Duarte , Da Silveira Juliana Penso , Santos Andressa Bessa , Ribeiro Asaph Lucas Cunha , Da Silva Daniele Oliveira Ferreira
Published: March 2022

A vulnerabilidade física e psíquica durante o período gravídico-puerperal (PGP) pode predispor a mulher ao adoecimento psíquico. Nesse contexto, esse trabalho objetivou revisar a literatura com a finalidade de verificar o impacto da pandemia de COVID-19 na saúde mental de puérperas, com enfoque na incidência de sintomas de depressão pós parto. Em 7 dos 8 estudos selecionados pela metodologia empregada, verificou-se aumento da incidência de sintomas depressivos no PGP após início da pandemia. Um dos estudos encontrou diminuição dos sintomas depressivos no PGP. A diminuição da rede de apoio e o menor contato com profissionais de saúde foram apontados como fatores responsáveis pela piora na saúde mental das puérperas.
Benefícios da farmacogenética para o direcionamento correto do tratamento farmacológico ao paciente: revisão integrativa
Authors: Kos Bruno Morais , Queiroz Grazielly Lima , Branco Alessandra Camillo da Silveira Castello
Published: March 2022

Introdução: A farmacogenética é uma área focada no entendimento e compreensão do metabolismo de fármacos, a partir dos genes do paciente, para melhorar o tratamento terapêutico. Objetivo: Revisar a literatura científica com a finalidade de verificar os benefícios da farmacogenética diante de alterações por polimorfismo em fármacos. Metodologia: Trata-se de uma revisão integrativa, utilizando estudos indexados em bases de dados, através de uma estratégia de busca baseada no acrônimo PICO. Resultados e Discussão: Foram encontrados 25.446 estudos, sendo 10 artigos selecionados através do critério de inclusão e exclusão estabelecidos. Dentre as possíveis modificações nas isoformas das enzimas na família da CYP 450, foram destacadas as CYP2C9 e CYP2D6. Classes farmacológicas como antidepressivos, anticoagulantes e inibidores de bomba de prótons apresentam ter interferência em sua eficácia pela expressão das enzimas metabolizadoras. Considerações finais: Infere-se que houve benefícios significativos utilizando a aplicação da farmacogenética para o tratamento individual ao paciente.
VIX KORKU ENDEKSİ VE GELİŞMEKTE OLAN ÜLKE BORSALARI ÜZERİNE AMPİRİK BİR ANALİZ
Authors: MÜNYAS Turgay
Published: March 2022

Korku Endeksi (VIX), finansal piyasalarda sermaye piyasası araçlarının gelecekte beklenen hareketlerinin tahmini için kullanılan önemli göstergelerden biridir.

Amaç: Bu çalışmanın amacı [01.01.2009-01.06.2020] aylık veriler için Korku Endeksi (VIX) endeksinin gelişmekte olan ülkeler olan Türkiye (BİST 100), Hindistan (BSE Sensex 30), Brezilya (Bovespa-BVSP), Rusya (MOEX Russia) ve Çin (Shanghai Composite-SSEC) borsaları ile ilişkisini uzun ve kısa dönem için analiz etmektir.

Yöntem: Durağanlık testleri için Augmented Dickey-Fuller (ADF) ve Phillips-Perron (PP) testleri uygulanmıştır. Uzun dönem ilişkinin incelenmesi için Bayer-Hanck (2013) Eşbütünleşme Analizi uygulanmıştır. Uzun dönemde birlikte hareket eden değişkenlerin kısa dönem dinamiklerini araştırmak amacıyla hata düzeltme modeli (Vector Error Correction Model: VECM) tahmin edilmiştir.

Bulgular: Araştırmanın sonucunda, Korku Endeksi (VIX) endeksinin gelişmekte olan ülke borsalarını olumsuz yönde etkilediği tespit edilmiştir. İncelemeye konu olan borsalardan Korku Endeksi (VIX) endeksindeki değişimden en çok etkilenen borsa Türkiye (BİST100) endeksi olmuştur. En az etkilenen borsa ise Brezilya (Bovespa-BVSP) endeksi olmuştur. Korku Endeksi (VIX) endeksinin borsalar üzerindeki etkisi kısa dönemde daha yüksek, uzun dönemde ise biraz daha azalarak devam etmektedir

Özgünlük: Bu konuda yapılan çalışmalar incelendiğinde, genellikle Korku Endeksi (VIX) çeşitli finansal göstergeler ve BİST 100 endeksi üzerinde bir etkisinin olup olmadığı araştırılmıştır. Bu çalışmada, kapsam geniş tutularak korku ikliminin gelişmekte olan ülke borsaları üzerindeki etkisi araştırılmıştır.
Influencia de la enseñanza en proyectos y las actividades extraescolares en el rendimiento académico de los alumnos en los Montes de María
Authors: Gutiérrez Yenifer Ángel Tovio , Ramos María Clareth Méndez , Gutierrez Katerine Edith Tobio , Morinson Melba Liliana Vertel
Published: March 2022

En Colombia, y en forma particular la costa Caribe Colombiana son pocas las investigaciones relativas a las actividades extraescolares como un puente que une el ámbito educativo y el ámbito asistencial en un ambiente colaborativo con la enseñanza-aprendizaje en proyectos y cómo influyen en el rendimiento académico del alumnado de Educación Obligatoria, principalmente de Educación Primaria. Es aquí donde se enmarca nuestra investigación, cuyo objetivo fue analizar la influencia de la enseñanza en proyectos y de actividades extraescolares con el rendimiento académico de alumnos de Educación Primaria en la subregión Montes de María, Sucre-Colombia. La población objeto de estudio son alumnos de quinto grado de Básica Primaria de dos instituciones educativas públicas de la subregión, para el análisis de la información se aplicó técnicas estadísticas descriptivas (uni-bivariado) y multivariadas (Análisis Factorial Múltiple –AFM-), para lo cual se utilizó el software R (R Development Core Team, 2019). Los resultados obtenidos mostraron que alumnos que practican actividades extraescolares, participan en el desarrollo de proyectos y poseen hábitos adecuados de estudio y de sueño presentan mejor rendimiento académico.
Desempeño del tutor desde la percepción del estudiante de enfermería
Authors: Martínez-García Gregorio Adrián , López-Cocotle José Juan , Ramón-Ramos Alexia , García-Jiménez José Roberto , González-Angulo Pedro , Ortiz-Ojeda Rosa Felicita
Published: March 2022

Objetivo: conocer el desempeño del tutor desde la percepción del estudiante de enfermería. Material y metodos: estudio cuantitativo, descriptivo y transversal. Se consideró el censo de estudiantes de la Licenciatura en Enfermería de un campus universitario del estado de Tabasco, México que reciben tutoría individual. Fueron 110 estudiantes los que cumplieron los criterios de selección. Se utilizó la sub-escala Desempeño del tutor de la Cédula de Evaluación de Tutoría, con un total de 19 ítems, cuenta con un Alpha de Cronbach de 0.90. Este estudio se realizó conforme a lo estipulado en el Reglamento de la Ley General de Salud en Materia de Investigación para la Salud. Resultados: del total de los participantes el 82.7% refieren que el desempeño del tutor es eficiente, seguido del 15.5% que lo consideran bueno y solo el 1.8% lo encuentra regular, ningún estudiante lo considera malo. El 94.5% refiere que si recomendaría su tutor a otros estudiantes. Conclusiones: el desempeño que tiene el tutor en el programa de Licenciatura en Enfermería de la DAMJM de la UJAT es eficiente, se puede percibir al tutor como eje articulador entre el programa de tutoría y el estudiante, ya que gracias a éste se logra que las acciones que se derivan del programa se ejecuten correctamente e impacten en la formación integral del estudiante universitario.
Pathogenic Photobacterium sp. induce mortality in the lined seahorse (Hippocampus erectus): First case report from China
Authors: ZHANG Shouyuan , ZHANG Shikui , BAI Xiaohui , LUO Zhang , LIU Jiabing , KE Ke
Published: March 2022

In August 2019, an unknown disease was first reported in farmed seahorses (Hippocampus erectus) in Binhai New Area in Tianjin city, China, with a cumulative mortality rate of 25% within seven days of onset. The main symptoms of the affected seahorses were discoloration of the body surface, abdominal distention, kidney erosion, and intestinal enlargement. Histopathological observation revealed apparent damage to the diseased seahorses’ intestines, liver, and kidneys. Strains HM-2019-5 and HM-2019-6 were isolated from diseased kidneys and identified as Photobacterium sp. based on physiological and biochemical tests and 16S rDNA sequencing analysis. Artificial infection experiments demonstrated that strain HM-2019-5 could cause a 90% morbidity rate in healthy seahorses. Antimicrobial susceptibility tests showed that HM-2019-5 and HM-2019-6 were resistant to 13 of 16 antimicrobial agents tested. This is the first report of photobacterial disease in a seahorse to the best of our knowledge.
Legal Politics of Environmental Protection and Management in Indonesia
Authors:   Faculty of Law, Universitas Diponegoro, A’yun Ayu Qurrota
Published: March 2022

This paper examines the position of Law No. 32 of 2009 concerning Environmental Protection and Management as a legal product based on the legal ideals of Pancasila and examines the legal politics of the position of Law No. 32 of 2009 concerning Environmental Protection and Management so that it can become a legal product that creates environmental sustainability. This paper uses a normative juridical method. The results of this paper indicate that Law No. 32 of 2009 concerning Environmental Protection and Management has a position under the goals of the Indonesian state, namely to create a good and healthy environment that makes people prosperous. It has been stated in Article 65 that everyone has the right to a good and healthy environment as part of human rights. The legal politics of Law Number 32 of 2009 concerning Environmental Protection and Management in accordance with the provisions of Article 28 H paragraph (1), Article 33 paragraph (3), (4) and (5) of the 1945 Constitution, which is the state's legal policy in managing the environment and use of natural resources.
THE EFFECTIVENESS OF INTRADIALYTIC STRETCHING EXERCISES REDUCTION OF MUSCLE CRAMPS AMONG PATIENTS UNDERGOING HEMODIALYSIS
Authors: saranaya Ms. Saranya , rani Dr. Rajrani
Published: March 2022

Renal failure could be a non-communicable unwellness that has drastically affected a majority of the globe population including Indians. With several patients undergoing qualitative analysis, muscle cramps square measure a typical complication during qualitative analysis treatments. Aim: To assess the effectiveness of intradialytic stretching exercises on reduction of muscle cramps among patients undergoing haemodialysis. Materials and Methods: A quantitative critical pre-experimental analysis style with one cluster pre-test pot-test was used. Sixty patients undergoing haemodialysis United Nations agency met the inclusion criteria were recruited victimization non chance purposive sampling technique. Intradialytic stretching exercises were performed for the gastronomies and soleus muscle (calf) muscles of the patient throughout the ordinal hour of haemodialysis. Knowledge collected before and when intervention was collected victimisation changed Penn’s Spasm Frequency Scale. Results: Findings disclosed that before performance of intradialytic stretching exercises, 66.7% and 33.3% of samples had usurious and severe muscle cramps severally. Post intervention one.7% of samples had severe muscle cramps, 8.3% had delicate muscle cramps and one.7% didn't have muscle cramps. This showed that intra dialytic stretching exercises were effective in reducing muscle cramps among patients undergoing hemodialysis.
Information Essence of Spiritual Substance and Universe and Man in Cosmology
Authors:   Research Department, Research Center, Natural Informatics, Novosibirsk, Russia, Bryndin Evgeny
Published: March 2022

So far, neither philosophers, nor scientists, nor theologians have been able to identify the origin and essence of information. The author reveals the essence of the information based on the opinion of Orthodox saints, as well as the opinion of the philosopher and theologian William Dembaki. The article is devoted to the consideration of the informational essence of the spiritual substance based on the reception of the logical and philosophical theological ideas of theology and cosmology about man and the Universe. The essence and participation of Wisdom in the creation of the Universe is considered. The essence of the information of the spiritual substance, as well as the secular and theological teachings about man and the Universe, is considered. A person’s soul, spirit, mind, as natural means of interaction with universal information, allows him to hypothesize, formulate theorems and prove them, form axioms and build theories, identify laws and laws, and make discoveries based on knowledge acquired in society. Secular knowledge makes us arrogant. Theological knowledge and life in love with people teaches us the right life. The article highlights the spiritual categories of the relationship between man and society with the universe in an ideal way, and also shows how these connections are established. Special attention is paid to the spiritual transformation of man and society, primarily due to a religious factor. Spiritual improvement contributes to the arrangement of universal life in love according to the will of God, an increase in the knowledge of spiritual substance and divine creation. The spiritual improvement of man and society contributes to the improvement of the skills of maintaining the original universal beauty by a harmonious combination of spiritual and informational aspects of eternal life.
An Alliance for Life
Authors:   Chairman of the Chico Mendes Committee, Acre. Brazil., Mendes Angela , Mendes Filha de Chico ,   Chairman of the Chico Mendes Committee, Acre. Brazil.
Published: March 2022

I begin this text with the sentence that my father left when he began to feel that his life was being threatened: “At first I thought I was fighting to save rubber trees, then I was fighting to save the Amazon Rainforest. Now, I realize that I’m fighting to save humanity. Chico Mendes, 1987”. The socio-environmental movement and its leaders are under threat today. The rubber tree is under threat. The Amazon is under threat. Humanity is under threat.
Sala de aula invertida
Authors: Pereira Santos William , Teixeira Gomes Fernando
Published: March 2022

Métodos ativos de ensino têm sido adotados na formação de profissionais de diferentes áreas, estimulando o pensamento crítico e melhorando o processo de ensino-aprendizagem. O formato de “sala de aula invertida” é uma ferramenta de aprendizagem que combina a preparação do aluno, que assume postura mais ativa, tornando-se o agente principal e (co)responsável pela sua aprendizagem, diferente do modelo tradicional de ensino que centra-se na transmissão unilateral do conhecimento, mostrando algumas deficiências no processo de ensino / aprendizagem. O presente relato de experiência tem como objetivo observar e avaliar a inserção da “sala de aula invertida” como metodologia ativa aplicada ao ensino de Bioquímica, com o intuito de sensibilizar os alunos a se aproximarem e desenvolverem habilidades que auxiliem na compreensão de conteúdos propostos e despertar o interesse dos mesmos para áreas ditas complexas e, por vezes, abstratas, além de investir na formação dos futuros docentes. O diálogo entre os resultados obtidos na atividade prática e o contexto, mediado por uma parceria colaborativa entre grupo instrutor e professor, sob a proposta crítico-reflexiva desencadeada pela metodologia ativa de “sala de aula invertida”, transformou o panorama do ensino superior, melhorando o processo de aprendizagem.
Resolução de Problemas em matemática
Authors: Poffo Possamai Janaína , Müller Jonathan Gil , Stein Suelen Sasse , Poffo Cíntia , Bertotti Junior Vilmar Ibanor
Published: March 2022

Este artigo tem como objetivo identificar características que permitem indicar quando uma aula de Matemática baseada em Resolução de Problemas está associada a uma metodologia ativa de ensino. Para tanto, fez-se um estudo teórico que se enquadra, quanto ao objetivo, como uma pesquisa descritiva e quanto ao procedimento, como bibliográfica, no qual se apresentam as concepções de metodologias ativas, bem como a Resolução de Problemas enquanto estratégia de ensino, definindo o entendimento de problema e o ensino para e através da Resolução de Problemas. Os resultados indicam que o papel do professor e dos estudantes, bem como a natureza das atividades matemáticas propostas, são o que definem a caracterização pretendida.
EĞİTİM SENDİKALARININ 2023 EĞİTİM VİZYONUNA İLİŞKİN GÖRÜŞLERİ
Authors: YAŞAR Ömer , ÇALIK Temel
Published: March 2022

Bu nitel araştırmanın amacı, eğitim, öğretim ve bilim hizmetleri kolundaki sendikaların 2023 Eğitim Vizyonuna ilişkin görüşlerini ortaya koymaktır. Veriler doküman incelemesi yöntemi ile toplanmıştır. Araştırmanın evrenini 2023 Eğitim Vizyonu hakkında internet web adreslerinde basın açıklamalarını yayınlayan (Eğitim Bir-Sen, Türk Eğitim-Sen, Eğitim-Sen, Eğitim-İş, Anadolu Eğitim Sen), eğitim, öğretim ve bilim hizmetleri iş kolunda en fazla üyeye sahip 5 sendikanın basın açıklamaları oluşturmaktadır. Elde edilen verilerin analizinde içerik analizi yöntemi kullanılmıştır. Yapılan analiz sonucunda basın açıklamalarında ifade edilen hedefler 5 tema başlığı altında sınıflandırılmıştır. Bunlar 19 hedeften oluşan Okul Gelişim Modeli; 7 hedeften oluşan Öğretmen; 2 hedeften oluşan Yönetim ve Denetim; 4 hedeften oluşan Öğrenci ve 13 hedeften oluşan Öğretim Programı (Müfredat) temalarıdır. “Ücretli öğretmenliğin ücretlerinin iyileştirilmesi” hedefini tüm sendikalar onaylamadıklarını ifade ederken; “Öğretmenlik meslek kanununu çıkarılması” hedefini tüm sendikalar onayladıklarını açıklamışlardır. En fazla değerlendirme “Öğretmen” ve “Öğretim Programı (Müfredat)” temalarına yapılırken en az değerlendirme “Öğrenci” ve “Yönetim ve Denetim” temalarına yapılmıştır. En fazla “onaylıyorum” değerlendirmesi yapılan tema “Okul Gelişim Programı” olurken en fazla “onaylamıyorum” değerlendirmesi yapılan tema “Öğretmen” teması olmuştur.
Evaluation of the Sensitivity and Specificity of three Rapid Test Kits Used in the Detection of Human Immunodeficiency Virus (Hiv) in Public Hospital Niger State, Nigeria
Authors: Saba Adamu Mohammed , Abdullahi Muhammad , John Baba , Angulu Samuel , Dogari James
Published: March 2022

Purpose: The assessment of HIV rapid test kits commonly used was evaluated for optimum performance on the suspected patient. This study aims to determine the sensitivity and specificity of rapid test kits used in public hospitals in Minna, Niger State.
Methods: A total of 300 gold positive and gold negative samples were analyzed. Three rapid test kits (Determine, Stat-Pak, and Uni-Gold) were tested against gold standard serum using the method provided by the manufacturers of these kits.
Results: Determine kit gave result sensitivity of (100%), specificity (96.5%), while Stat-Pak sensitivity was (99%), specificity (98%) and Uni-Gold sensitivity (100%), specificity (99%). In all Uni-Gold has the highest performance followed by Stat-Pak and lastly, Determine, but the differences were not statistically significant (p>0.05).
Conclusion: This evaluation provides evidence for reliable rapid test kits for HIV testing in Nigeria. However, the claim by the manufacturers that their kit was 100% sensitive and 100% specific remains doubtful which may be a market strategy. Therefore, it is pertinent on a routine basis to evaluate the rapid test kits in circulation to re-validate their performance before usage for accurate HIV testing.
Development and Evaluation of Elisa Kits Based on Proteomics Technology for Detection and Semi-Quantification of Meat Species Adulteration
Authors: Ahmed Manal Mohamed Elsayed , Nazmy Walid , Noureen Asmaa
Published: March 2022

Purpose: This study aimed to develop ELISA kits for the detection of meat species adulteration in raw and processed meat and evaluate its specificity and sensitivity.
Method: We identify the unique peptide markers based on the proteomics approach. Subsequently, we prepared specific antisera for beef, pork, horse, sheep, chicken and developed ELISA kits.
Results: Evaluation of the developed kits in testing crooked reference sample mixtures revealed that the developed  ELISA kits showed 100% specificity with no cross-reactivity detected for the non-target species. In terms of sensitivity, the developed ELISA kits were able to consistently detect pork in the sample mixtures and horses at levels down to 5% w/w. Although sheep and chicken were detected at levels as low as 1% w/w. The beef-specific ELISA test showed greater sensitivity.
 
Conclusions: It is concluded that the developed ELISA kits are a promising tool but further studies are still required for validation of the developed kits and comparing its results with the commercially used kits before entry into the production phase.