bluuebunny/crossref_metadata_2025 huggingface dataset:
Employers’ Perceptions of the Manufacturing Industry on Workplace Safety Culture
Authors: Mohd Nawi Mohd Nasrom , Zainol Nur Azizah , Naim Faridah , Mamat Mohd Noor , Hamzah Nurul Ainun , Mohd Nawi Mohd Nazhari
Published: July 2023

Employees play important roles regarding safety culture in the manufacturing industry. The study was conducted among 108 manufacturing workers and aimed to determine employees' perceptions of safety culture in the manufacturing industry. The data obtained were analysed to see the relationship between sociodemographic factors and safety culture dimensions to safety performance. The four aspects of perception include four dimensions of management commitment, employee engagement, communication, and training and education. Demographic factors such as age and duration of work were not significantly related to variables related to staff perceptions (p > 0.05). In addition, the relationship between aspects of security culture dimensions and safety performance showed that there was a significant relationship between communication having the highest relationship (r = 0.403, P < 0.01) and the lowest relationship by management commitment dimension (r = 0.244, p < 0.01). The overall a grand total of these studies show a significant positive relationship with workers’ safety in the workplace (r = 0.377, p < 0.01). Therefore, companies are encouraged to increase training programs in the workplace to raise awareness of workplace hazard awareness as well as ongoing health and safety programs through helpful channels for employees to reduce workplace accidents.
Concerns of Airborne Ammonia in Ice-Production Facilities: Enhancing protection of workers in Malaysia.
Authors: Yon Hazlina
Published: July 2023

A study on profiling of ammonia concentration and its validation using two types of direct reading instruments has been conducted for eight months from September 2021 till May 2022 in four different zones in West Malaysia. The study is using a high performance multigas analyzer integrated with Fourier Transform Infrared (FTIR) and Multirae data analyzer to measure ammonia concentration in thirty-eight ice-production facilities in Malaysia. This study is limited to databases of ice-production facilities registered with the Department of Occupational Safety and Health (DOSH) Malaysia. The study involves thirty-eight ice-production facilities with fourteen compliance verification using USECHH checklist. The results of monitoring and validation confirmed that ammonia is detected at various locations in the factory layout. It is found to be localized and concentrated at the machine room followed by machine room combined with production room.  Both instruments seem to show similar trend which can validate the profile obtained for ammonia in the ice facilities. Recommendations are suggested for employers to improve layout of the ice-production facilities based on these measurements.

The study also seeks to find a correlation between the compliance of these facilities with the Use and Standards of Exposure of Chemicals Hazardous to Health (USECHH) Regulations 2000 and compliance with ammonia checklist from the Guideline of Safe Management of Ammonia Refrigeration System 2020. Pre and post assessment is conducted using the same ammonia checklist to identify any gap. It was found that the results obtained for the USECHH compliance, ammonia checklist compliance either pre or post assessment are not positively correlated. This finding emphasizes that there is still a lack of commitment from these ice-production facilities even after the visits by authorities. Comparison between the monitoring data and the degree of compliance using ammonia checklist from the said guideline was also made. The results obtained emphasize that there is no strong correlation between the monitoring data and the degree of compliance using the ammonia checklist.

            This study shows an insight of chemical management in Malaysia at ice-production facilities and provides suggestions, recommendations, measures and outcomes of enforcement. Future measures to be taken is also suggested to boost compliance. At the same time, the outcomes and implications of this study on chemical management and chemical safety status in Malaysia can also assist other developing countries to improve their chemical management. Future research with risk modelling of ammonia leakages could also be ventured into. Ice plants are recommended to redesign their layout based on this study.

Keywords: ammonia profiling, compliance enforcement, ice production facilities, lack of commitment, USECHH compliance.
On the boundedness and norm of certain generalized Hilbert operators in ℓp$\ell ^p$
Authors: Athanasiou Nikolaos
Published: July 2023

The Hilbert matrix has been extensively studied in the previous literature. In this paper, we look at generalized Hilbert operators arising from measures on the interval [0,1], such that the Hilbert matrix is obtained by the Lebesgue measure. We provide a necessary and sufficient condition for these operators to be bounded in and calculate their norm. Interestingly, we obtain complete results in this direction for both .
Transitando a la salud colectiva : una experiencia de la Facultad de Enfermería de la Pontificia Universidad Javeriana
Authors:   Pontificia Universidad Javeriana, Camargo-Rojas Claudia Marcela , Téllez Pedroza Marlín , Suárez Castro Edilma Marlén ,   Pontificia Universidad Javeriana, Quevedo León Liliana , Niño Cardozo Carmen Lucía , Melo-Hurtado Dora Stella , Lozano Beltrán Jenny Amparo , Granja Palacios Consuelo , Córdoba Rojas Diana Norella
Published: July 2023

Este libro tiene como propósito visibilizar la participación y el aporte de la Facultad de Enfermería de la Pontificia Universidad Javeriana a la salud colectiva, enmarcada en el contexto de la salud colombiana, la articulación histórica y los aportes de enfermería a las corrientes de pensamiento en salud pública en Colombia, a través del caso particular del Departamento de Enfermería en Salud Colectiva. Para ello, se realiza un recuento histórico en perspectiva crítica de la enfermería y la salud pública hasta la creación del Departamento de Enfermería en Salud Colectiva; de igual forma, se presentan los desarrollos en investigación, con preeminencia en un abordaje cualitativo, el enfoque curricular en salud pública y su materialización en tres de las prácticas llevadas a cabo con los estudiantes de pregrado.
Sound power and acoustic efficiency of an installed GE F404 jet engine
Authors: Christian Matthew A. , Gee Kent L. , Streeter Jacob B. , Wall Alan T. , Campbell Steven C.
Published: July 2023

Classical jet noise theory indicates that radiated sound power is proportional to the jet velocity raised to the eighth and third powers for subsonic and supersonic jets, respectively. To connect full-scale measurements with classical jet noise theory, this letter presents sound power and acoustic efficiency values for an installed GE-F404 engine. When subsonic, the change in sound power follows the eighth-power law, and the sound power change approximately follows the third-power law at supersonic conditions, with an acoustic efficiency of ∼0.5-0.6%. However, the OAPWL increase from subsonic to supersonic jet velocities is greater than would be predicted.
Harmonic-aware tri-path convolution recurrent network for singing voice separation
Authors: Shen Yih-Liang , Lai Ya-Ching , Chi Tai-Shih
Published: July 2023

Temporal coherence and spectral regularity are critical cues for human auditory streaming processes and are considered in many sound separation models. Some examples include the Conv-tasnet model, which focuses on temporal coherence using short length kernels to analyze sound, and the dual-path convolution recurrent network (DPCRN) model, which uses two recurring neural networks to analyze general patterns along the temporal and spectral dimensions on a spectrogram. By expanding DPCRN, a harmonic-aware tri-path convolution recurrent network model via the addition of an inter-band RNN is proposed. Evaluation results on public datasets show that this addition can further boost the separation performances of DPCRN.
Why the day is 24 hours long: The history of Earth’s atmospheric thermal tide, composition, and mean temperature
Authors: Wu Hanbo , Murray Norman , Menou Kristen , Lee Christopher , Leconte Jeremy
Published: July 2023

The Sun drives a semidiurnal (12-hour) thermal tide in Earth’s atmosphere. Zahnle and Walker suggested that an atmospheric oscillation with period
P
res
≈ 10.5 hours resonated with the Solar driving ≈600 million years ago (Ma), when the length of day (lod) was ≈21 hours. They argued that the enhanced torque balanced the Lunar tidal torque, fixing the lod. We explore this hypothesis using two different global circulation models (GCMs), finding
P
res
= 11.4 and 11.5 hours today, in excellent agreement with a recent measurement. We quantify the relation between
P
res
, mean surface temperature

T
¯

, composition, and Solar luminosity. We use geologic data, a dynamical model, and a Monte Carlo sampler to find possible histories for the Earth-Moon system. In the most likely model, the lod was fixed at ≈19.5 hours between 2200 and 600 Ma ago, with sustained high

T
¯

and an increase in the angular momentum
L
EM
of the Earth-Moon system of ≈5%.
Hypoxia sensing requires H
2
S-dependent persulfidation of olfactory receptor 78
Authors: Peng Ying-Jie , Nanduri Jayasri , Wang Ning , Kumar Ganesh K. , Bindokas Vytautas , Paul Bindu D. , Chen Xuanmao , Fox Aaron P. , Vignane Thibaut , Filipovic Milos R. , Prabhakar Nanduri R.
Published: July 2023

Oxygen (O
2
) sensing by the carotid body is critical for maintaining cardiorespiratory homeostasis during hypoxia. Hydrogen sulfide (H
2
S) signaling is implicated in carotid body activation by low O
2
. Here, we show that persulfidation of olfactory receptor 78 (Olfr78) by H
2
S is an integral component of carotid body activation by hypoxia. Hypoxia and H
2
S increased persulfidation in carotid body glomus cells and persulfidated cysteine
240
in Olfr78 protein in heterologous system.
Olfr78
mutants manifest impaired carotid body sensory nerve, glomus cell, and breathing responses to H
2
S and hypoxia. Glomus cells are positive for G
Olf,
adenylate cyclase 3 (Adcy3) and cyclic nucleotide–gated channel alpha 2 (Cnga2), key molecules of odorant receptor signaling.
Adcy3
or
Cnga2
mutants exhibited impaired carotid body and glomus cell responses to H
2
S and breathing responses to hypoxia. These results suggest that H
2
S through redox modification of Olfr78 participates in carotid body activation by hypoxia to regulate breathing.
Physically defined long-term and short-term synapses for the development of reconfigurable analog-type operators capable of performing health care tasks
Authors: Choi Yongsuk , Ho Dong Hae , Kim Seongchan , Choi Young Jin , Roe Dong Gue , Kwak In Cheol , Min Jihong , Han Hong , Gao Wei , Cho Jeong Ho
Published: July 2023

Extracting valuable information from the overflowing data is a critical yet challenging task. Dealing with high volumes of biometric data, which are often unstructured, nonstatic, and ambiguous, requires extensive computer resources and data specialists. Emerging neuromorphic computing technologies that mimic the data processing properties of biological neural networks offer a promising solution for handling overflowing data. Here, the development of an electrolyte-gated organic transistor featuring a selective transition from short-term to long-term plasticity of the biological synapse is presented. The memory behaviors of the synaptic device were precisely modulated by restricting ion penetration through an organic channel via photochemical reactions of the cross-linking molecules. Furthermore, the applicability of the memory-controlled synaptic device was verified by constructing a reconfigurable synaptic logic gate for implementing a medical algorithm without further weight-update process. Last, the presented neuromorphic device demonstrated feasibility to handle biometric information with various update periods and perform health care tasks.
Development of organic reactions that productively leverage physical properties
Authors: Cassels William R. , Johnson Jeffrey S.
Published: July 2023

Crystallization-induced stereoconvergent Michael additions demonstrate the potential of using physical properties to reveal unique reactivity.
Soft, bioresorbable, transparent microelectrode arrays for multimodal spatiotemporal mapping and modulation of cardiac physiology
Authors: Chen Zhiyuan , Lin Zexu , Obaid Sofian N. , Rytkin Eric , George Sharon A. , Bach Christopher , Madrid Micah , Liu Miya , LaPiano Jessica , Fehr Amy , Shi Xinyu , Quirion Nathaniel , Russo Benjamin , Knight Helen , Aduwari Anthony , Efimov Igor R. , Lu Luyao
Published: July 2023

Transparent microelectrode arrays (MEAs) that allow multimodal investigation of the spatiotemporal cardiac characteristics are important in studying and treating heart disease. Existing implantable devices, however, are designed to support chronic operational lifetimes and require surgical extraction when they malfunction or are no longer needed. Meanwhile, bioresorbable systems that can self-eliminate after performing temporary functions are increasingly attractive because they avoid the costs/risks of surgical extraction. We report the design, fabrication, characterization, and validation of a soft, fully bioresorbable, and transparent MEA platform for bidirectional cardiac interfacing over a clinically relevant period. The MEA provides multiparametric electrical/optical mapping of cardiac dynamics and on-demand site-specific pacing to investigate and treat cardiac dysfunctions in rat and human heart models. The bioresorption dynamics and biocompatibility are investigated. The device designs serve as the basis for bioresorbable cardiac technologies for potential postsurgical monitoring and treating temporary patient pathological conditions in certain clinical scenarios, such as myocardial infarction, ischemia, and transcatheter aortic valve replacement.
Formation of polyrotaxane crystals driven by dative boron–nitrogen bonds
Authors: Xiao Xuedong , Xiao Ding , Sheng Guan , Shan Tianyu , Wang Jiao , Miao Xiaohe , Liu Yikuan , Li Guangfeng , Zhu Yihan , Sessler Jonathan L. , Huang Feihe
Published: July 2023

The integration of mechanically interlocked molecules (MIMs) into purely organic crystalline materials is expected to produce materials with properties that are not accessible using more classic approaches. To date, this integration has proved elusive. We present a dative boron–nitrogen bond-driven self-assembly strategy that allows for the preparation of polyrotaxane crystals. The polyrotaxane nature of the crystalline material was confirmed by both single-crystal x-ray diffraction analysis and cryogenic high-resolution low-dose transmission electron microscopy. Enhanced softness and greater elasticity are seen for the polyrotaxane crystals than for nonrotaxane polymer controls. This finding is rationalized in terms of the synergetic microscopic motion of the rotaxane subunits. The present work thus highlights the benefits of integrating MIMs into crystalline materials.
Dysregulated IFN-γ signals promote autoimmunity in STAT1 gain-of-function syndrome
Authors: Largent Andrea D. , Lambert Katharina , Chiang Kristy , Shumlak Natali , Liggitt Denny , Oukka Mohammed , Torgerson Troy R. , Buckner Jane H. , Allenspach Eric J. , Rawlings David J. , Jackson Shaun W.
Published: July 2023

Heterozygous signal transducer and activator of transcription 1 (
STAT1
) gain-of-function (GOF) mutations promote a clinical syndrome of immune dysregulation characterized by recurrent infections and predisposition to humoral autoimmunity. To gain insights into immune characteristics of STAT1-driven inflammation, we performed deep immunophenotyping of pediatric patients with STAT1 GOF syndrome and age-matched controls. Affected individuals exhibited dysregulated CD4
+
T cell and B cell activation, including expansion of T
H
1-skewed CXCR3
+
populations that correlated with serum autoantibody titers. To dissect underlying immune mechanisms, we generated
Stat1
GOF transgenic mice (

Stat1
GOF

mice) and confirmed the development of spontaneous humoral autoimmunity that recapitulated the human phenotype. Despite clinical resemblance to human regulatory T cell (T
reg
) deficiency,

Stat1
GOF

mice and humans with STAT1 GOF syndrome exhibited normal T
reg
development and function. In contrast, STAT1 GOF autoimmunity was characterized by adaptive immune activation driven by dysregulated STAT1-dependent signals downstream of the type 1 and type 2 interferon (IFN) receptors. However, in contrast to the prevailing type 1 IFN-centric model for STAT1 GOF autoimmunity,

Stat1
GOF

mice lacking the type 1 IFN receptor were only partially protected from STAT1-driven systemic inflammation, whereas loss of type 2 IFN (IFN-γ) signals abrogated autoimmunity. Last, germline
STAT1
GOF alleles are thought to enhance transcriptional activity by increasing total STAT1 protein, but the underlying biochemical mechanisms have not been defined. We showed that IFN-γ receptor deletion normalized total STAT1 expression across immune lineages, highlighting IFN-γ as the critical driver of feedforward STAT1 elevation in STAT1 GOF syndrome.
Class-Driven Synergy and Antagonism between a Pseudomonas Phage and Antibiotics
Authors: Nicholls Paul , Clark Justin R. , Gu Liu Carmen , Terwilliger Austen , Maresso Anthony W.
Published: July 2023

The ubiquitous bacterial pathogen
Pseudomonas aeruginosa
is responsible for severe infections in patients with burns, cystic fibrosis, and neutropenia. Biofilm formation gives physical refuge and a protected microenvironment for sessile cells, rendering cure by antibiotics a challenge.
Metagenomic Analysis of a Concrete Bridge Reveals a Microbial Community Dominated by Halophilic Bacteria and Archaea
Authors: Kiledal E. Anders , Shaw Mark , Polson Shawn W. , Maresca Julia A.
Published: July 2023

Prior work on the microbial communities of concrete focused on the surfaces of concrete structures such as sewage pipes or bridge pilings, where thick biofilms were easy to observe and sample. Because the biomass inside concrete is so low, more recent analyses of the microbial communities inside concrete used amplicon sequencing methods to describe those communities.
Rare Extranodal Manifestation of Rosai-Dorfman Disease Presenting as Nasal Obstruction and its Management
Authors: Oui Ting Jie , Zahedi Farah Dayana , Husain Salina , Wan Hamizan Aneeza Khairiyah
Published: July 2023

Rosai-Dorfman disease (RDD) is a rare and benign lymphoproliferative disorder that commonly presents as painless, bilateral neck swelling. Extranodal presentations are considered rare, but the most common extranodal locations involved include skin, subcutaneous followed by nasal/paranasal sinuses. Although it is a benign condition, it may be mistaken as a malignant lesion and requires a biopsy for diagnostic confirmation. In this study, we report a rare case of RDD with bilateral neck node and nasal/paranasal sinus involvement which initially presented with bilateral nasal obstruction. And, we reviewed the management in this unusual case and discussed the helpful role imaging studies play in the further workup and subsequent follow-up to treatment response.
HaemorrhagicMycobacterium aviumcomplex pericarditis presenting with cardiac tamponade in an immunocompetent woman
Authors: Anthony Jamal A , Williams Karlene
Published: July 2023

A young woman in her mid-40s was referred by her primary care physician for fever, worsening shortness of breath, pleuritic chest pain and tachycardia. CT angiogram of the chest revealed a large pericardial effusion. Echocardiogram confirmed tamponade physiology despite her being haemodynamically stable. She had an emergency pericardiocentesis which revealed evidence of a haemorrhagic pericardial effusion. However, the patient was still symptomatic after treatment and had to undergo video-assisted thoracoscopic surgery with a pericardial window and chest tube. Postoperatively, her fevers resolved. Pan-culture was initially negative, and all antibiotics were discontinued. Acid-fast bacilli cultures later grewMycobacterium aviumcomplex. She continued to have chest discomfort postoperatively, but follow-up CT of the chest 3 months postoperatively showed continued resolution of her pericardial effusion. The patient’s symptoms improved, and she has had no recurrence of effusion without the need for anti-tuberculosis drugs.
‘DISSEMINATE’: a roadmap for facilitating adoption of affordable surgical innovations in low and middle-income countries
Authors: Sharma Dhananjaya , Agrawal Vikesh , Sam-Agudu Nadia Adjoa , Agarwal Pawan , Yadav Sanjay Kumar , Bajaj Jitin
Published: July 2023

Importance

Affordable surgical innovations (ASIs) provide simple, safe and equitable solutions in resource-limited settings. Effective dissemination is needed for widespread adoption and uptake of ASIs in low and middle-income countries (LMICs). However, surgical systems in these settings face challenges with adoption and uptake of ASIs, which remain unknown and/or unused even after supporting evidence is published. A surgery-specific, implementation science-informed framework can provide a roadmap delineating the actions needed to achieve this goal; however, none exist currently. This prompted the development of a well-defined roadmap for this purpose.

Methods

The roadmap was developed after several rounds of structured brainstorming discussions among the authors, who are LMIC-based experts in academic surgery, ASIs, global health and implementation science.

Results and conclusion

The proposed ‘DISSEMINATE’ roadmap presents 18 non-sequential domains to be considered in a comprehensive approach to equitable accessibility for surgical innovations:Designof the innovation;Innovateby combining the IDEAL (Idea,Development,Exploration,Assessment andLong-term follow-up) surgical innovation framework with local multidisciplinary expertise;Substantiateavailable evidence;Scale upapplication of evidence in surgical practice;Shareknowledge on multidisciplinary platforms;Sustainability;Endorsementof the innovation by local catalysts;Mediapromotion;Identifyearly adopters;Improveand refine the innovation;Improviseduring setbacks;Implementationscience methods;Navigatethrough barriers;Aspirationalaffordability;Advocacyfor the value of ASIs;Toolsfor scalability and adoption;Evaluateimpact of dissemination; andExtenduse of the innovation to resource-rich settings. This surgery-specific roadmap provides structure for effective dissemination to help in overcoming know-do gaps in the use of ASIs in LMICs.
Outcomes after implantation of right-sided mechanical valve prostheses in congenital heart disease
Authors: Abozied Omar , Miranda William , Younis Ahmed , Burchill Luke , Jain Charles , Connolly Heidi , Dearani Joseph , Stephens Elizabeth H , Egbe Alexander C
Published: July 2023

Background

Bioprosthetic valves are often used for pulmonary valve replacement (PVR) and tricuspid valve replacement (TVR) because of concerns about mechanical valve thrombosis in the right heart. The purpose of this study was to assess prosthetic valve function and outcomes (prosthetic valve dysfunction, reoperations and major bleeding events) after mechanical PVR and TVR and to compare these to bioprostheses implanted in the same positions.

Method

Case–control study of adults with congenital heart disease that underwent mechanical TVR or PVR (2003–2021) at Mayo Clinic Rochester, Minnesota. For each mechanical prosthesis, we identified two patients that received bioprosthesis in the same position (1:2 matching).

Results

We identified 48 consecutive patients that underwent mechanical PVR (n=39, age 32 (26–38) years, men 22 (56%)) and/or mechanical TVR (n=17, age 36 (31–42) years, men 9 (53%)), as control group of 78 patients (age 30 (24–36) years, men 44 (56%)) and 34 patients (age 34 (29–39) years, men 18 (53%)) that underwent bioprosthetic PVR and TVR, respectively. The most common diagnoses in patients that received mechanical prosthesis were: tetralogy of Fallot (n=14, 19%), aortic stenosis status post Ross operation (n=11, 23%), truncus arteriosus (n=5, 11%), atrioventricular canal defect (n=4, 8%), Ebstein anomaly (n=3, 6%), double outlet right ventricle (n=2, 4%), valvular pulmonic stenosis (n=2, 4%). Compared with the bioprosthesis group, the mechanical prosthesis group had lower temporal increase in Doppler systolic mean gradient after PVR (∆ −1±2 vs 3±2 mm Hg, p<0.001) and Doppler diastolic mean gradient after TVR (∆ 0±1 vs 2±1 mm Hg, p=0.005). The mechanical prosthesis group also had lower risk of prosthetic valve dysfunction after PVR (1.0% vs 2.8% /year, p=0.02) and after TVR (2.6% vs 4.3% /year, p=0.008), but higher risk of major bleeding events (2.2% vs 0.1% /year, p<0.001).

Conclusions

Patients that received right-sided mechanical valve prostheses had lower temporal increase in valve gradient, lower risk of prosthetic valve dysfunction, but higher risk of bleeding complications compared with those that underwent right-sided bioprosthetic valve implantation.
Challenging event horizons with spin (3/2) fields
Authors: Düztaş Koray
Published: July 2023

We attempt to destroy the event horizons of Kerr black holes by perturbing them with massless spin (3/2) fields. We carry out a detailed analysis by incorporating the explicit form of the absorption probabilities and backreaction effects due to the self energy of the test fields. For extremal and nearly extremal black holes, backreaction effects dominate for perturbations with large magnitudes. However, small perturbations can destroy the event horizons of extremal black holes and drive nearly extremal black holes closer to extremality. Eventually, nearly extremal black holes reach a certain stage where they can be continuously driven to extremality and beyond. Both the cosmic censorship conjecture and the third law of black hole dynamics can be violated by spin (3/2) fields. This directly follows from the fact that fermionic fields do not satisfy the null energy condition. Therefore this result does not contradict with the fact that cosmic censorship and the laws of black hole mechanics remain valid for perturbations satisfying the null energy condition.
Quantitative evidence for Arctic continental freezing in a high-CO
2
world: Junggar Basin, NW China
Authors: Chang Clara Y. , Kinney Sean T. , Fang Yanan , Sha Jingeng , Olsen Paul E.
Published: July 2023

We show that the Late Triassic–Early Jurassic continental Arctic experienced wintertime freezing conditions, despite the exceptionally high atmospheric CO
2
levels, by quantifying common lake ice-rafted debris (L-IRD) identified in the Junggar Basin of Xinjian, NW China. This L-IRD consists of outsized (0.1–12 mm) lithic clasts ‘floating’ in otherwise fine-grained, profundal lake sediment matrix. Laser-diffraction grain-size analysis demonstrates that the grain-size distribution for lacustrine strata of Junggar Basin is very similar to modern sediments from the seasonally ice-covered Sea of Okhotsk, reflecting a similar depositional mechanism. Three-dimensional computed tomography and two-dimensional thin sections demonstrate that the outsized clasts are dispersed, rather than confined to sand lenses or layers. These results are inconsistent with alternative methods of bimodal sediment deposition such as mud flows, algae rafting or root rafting. The discovery of Triassic–Jurassic continental freezing provides new context for understanding global climate during periods with high-CO
2
conditions and climate and biotic changes in the Mesozoic Era.
Enriching Image Archives via Facial Recognition
Authors: Milleville Kenzo , Van den Broeck Alec , Vanderperren Nastasia , Vissers Rony , Priem Matthias , Van de Weghe Nico , Verstockt Steven
Published: July 2023

The digitization of image archives across the globe has opened up vast collections of libraries, museums, and cultural heritage institutions. These collections provide valuable historical information to the public and researchers. Many image collections have little metadata describing who or what is depicted in a structured format, making it difficult to search for specific persons. This work presents a facial recognition pipeline to enrich these collections by recognizing the persons in each image. A reference dataset of over 6,000 known persons was constructed and facial recognition was performed on a dataset of over 150 thousand images. Detected faces were matched with the known faces using a similarity score on the face embeddings. We developed an interactive labeling tool to efficiently validate the face recognition predictions. A total of 182 thousand detected faces were labeled with this tool. Using a minimum similarity score of 0.5, the face recognition model achieved a precision of 0.936 and identified over 62 thousand persons from the image archives. We show how clustering can be used to identify new persons that were not included in the reference dataset. Furthermore, we highlight the potential of facial recognition to enhance the accessibility of the collections and offer new insights.
Owner-free Distributed Symmetric Searchable Encryption Supporting Conjunctive Queries
Authors: Tong Qiuyun , Li Xinghua , Miao Yinbin , Wang Yunwei , Liu Ximeng , Deng Robert H.
Published: July 2023

Symmetric Searchable Encryption (SSE), as an ideal primitive, can ensure data privacy while supporting retrieval over encrypted data. However, existing multi-user SSE schemes require the data owner to share the secret key with all query users or always be online to generate search tokens. While there are some solutions to this problem, they have at least one weakness, such as non-supporting conjunctive query, result decryption assistance of the data owner, and unauthorized access. To solve the above issues, we propose an
O
wner-free
Di
stributed
S
ymmetric searchable encryption supporting
C
onjunctive query (ODiSC). Specifically, we first evaluate the Learning-Parity-with-Noise weak Pseudorandom Function (LPN-wPRF) in dual-cloud architecture to generate search tokens with the data owner free from sharing key and being online. Then, we provide fine-grained conjunctive query in the distributed architecture using additive secret sharing and symmetric-key hidden vector encryption. Finally, formal security analysis and empirical performance evaluation demonstrate that ODiSC is adaptively simulation-secure and efficient.
Developing Coding Instruction Videos for K12 Hearing Impaired Students Using American Sign Language
Authors: Marghitu Daniela , Howard Ayanna , Das Meenakshi
Published: July 2023

Disability Inclusion and Accessibility in technology has today emerged as a necessity of national importance. NSF funded projects like AccessCSforALL, Bootstrap, and CSforAll are making efforts to make computer science (CS) inclusive to the 7.4 million K-12 students with disabilities. Bringing people with disabilities into the tech workforce would not only create equal opportunities for all but would also better equip the society to serve its diverse population. Our proposed project focuses on making CS concepts accessible to K-12 students who are deaf or hard-of-hearing (D/HH).
Two-Hit Model of Behavioral Inhibition and Anxiety
Authors: Ostlund Brendan , Pérez-Edgar Koraly
Published: July 2023

Four decades of research have examined the antecedents and consequences of behavioral inhibition (BI), a temperament profile associated with heightened reactivity to sensory stimuli in infancy, reticence toward social cues in childhood, and the later emergence of social anxiety in adolescence. This review proposes that a two-hit model can supplement prior work to better understand these developmental pathways. Specifically, time limited experiences (“hits”) centered in infancy and adolescence stress idiosyncratic BI-linked processes that uniquely trigger the developmental pathway from temperament to disorder. To illustrate, we focus on caregiver distress in infancy (including fetal development), social reorientation in adolescence, and their impact on malleable attentional and cognitive systems. These are developmental challenges and processes that go to the heart of the BI phenotype. Finally, we note open questions in this conceptual model, potential caveats, and needed future research.
Investigation on Thermal Energy Storage Properties of Polyethylene Glycol with Hybrid Nanoparticles of Al2O3 and CuO for Solar Thermal Energy Storage
Authors: Pandya Mohit , Ansu A. K. , Sharma R. K. , Tripathi D. , Tyagi V. V. , Sari Ahmet
Published: July 2023

The ability to store high latent heat energy makes polyethylene glycol (PEG) one of the most promising materials in the organic phase change material (PCM) family. Nevertheless, the poor heat conductivity limits its potential to a large extent in the real time applications. In this study, polyethylene glycol (PEG2000) was incorporated with nano aluminium oxide (Al2O3) and copper oxide (CuO) composites to develop a hybrid nanomaterials based PCM with higher thermal conductivity. To accomplish the objectives of the study, six (06) samples were prepared. It was ensured that the total mass of both the nano particles remains 3% of the total mass of the sample. For characterization of the samples, FTIR, TGA, DSC, XRD techniques were used to test the thermal and chemical stability of the materials. The results show that the prepared composite has higher thermal conductivity than pure PCM and they are also chemically and thermally stable. Also, the interaction between PCM and nanoparticles is purely physical. The DSC findings showed that the developed nano enhanced PCM possess significantly high latent heat. The developed composites have the potential of being used as thermal energy storage materials for electronic board and various solar based applications.
Review—The K2SiF6:Mn4+ (PFS/KSF) Phosphor
Authors: Cohen W. E. , Du F. , Beers W. W. , Srivastava A. M.
Published: July 2023

In the modern-day phosphor-converted light emitting diodes (pc-LEDs), white-light for general illumination is generated by combiningblue light from the InGaN chip with the yellow-green emission of Ce doped garnet phosphor and a red emitter. The red emitter is required to induce a “warm-white” color temperature (2700–3500 K). The optical properties of the red emitter are critical to achieving high luminous efficacy (lumens per watt or LPW) and high color rendering index (CRI) of the white light. The red emitter must display both strong absorption at 450 nm and sharp line emission in the range of 610 nm − 650 nm. Currently, the red emitter that satisfies these requirements is the K2SiF6:Mn4+ (PSF/KFS) phosphor. This review summarizes the fundamental aspects of the Mn4+ ion luminescence in solids, the spectroscopic properties of the Mn4+ ion in K2SiF6 and the manufacturing procedures with particular emphasis on post-synthesis processes that are required to produce phosphor with acceptable reliability. The review also discusses alternate compositions, future improvements, and challenges.
Dissecting unsupervised learning through hidden Markov modeling in electrophysiological data
Authors: Masaracchia Laura , Fredes Felipe , Woolrich Mark W. , Vidaurre Diego
Published: July 2023

Compared with classical supervised methods, unsupervised methods of analysis have the advantage to be freer of subjective biases. However, it is not always clear what aspects of the data these methods are most sensitive to, which complicates interpretation. Focusing on the hidden Markov model, commonly used to describe electrophysiological data, we explore in detail the nature of its estimates through simulations and real data examples, providing important insights about what to expect from these models.
Exploring the role of task success in implicit motor adaptation
Authors: Al-Fawakhiri Naser , Ma Ambri , Taylor Jordan A. , Kim Olivia A.
Published: July 2023

Recent work has suggested that task success, namely, hitting a target, influences implicit motor adaptation. Here, we observed that implicit adaptation is modulated by target jump manipulations, where the target abruptly “jumps” to meet the cursor; however, implicit adaptation was only weakly modulated by target size manipulations, where a static target either envelops or excludes the cursor. We discuss how these manipulations may exert their effects through different mechanisms.
Priming of the autonomic nervous system after an experimental human pain model
Authors: Scheuren Paulina Simonne , Bösch Sofia , Rosner Jan , Allmendinger Florin , Kramer John Lawrence Kipling , Curt Armin , Hubli Michèle
Published: July 2023

The facilitation of pain-induced sympathetic skin responses observed after experimentally induced central sensitization is unspecific to the stimulation modality and thereby unlikely solely driven by nociceptive sensitization. In addition, these enhanced pain-induced autonomic responses are also not related to higher stimulus-associated arousal, but rather a general priming of the autonomic nervous system. Hence, autonomic readouts may be able to detect generalized hyperexcitability in chronic pain, beyond the nociceptive system, which may contribute to clinical pain phenotypes.
LINC00174 Promotes Colon Cancer Progression by Regulating Inflammation and Glycolysis by Targeting the MicroRNA-2467-3p/Enolase 3 Axis
Authors: Xu Sheng , Lin Jiawei , Chen Rong , Xie Junjie , Yuan Enquan , Cen Fajie , Kong Fanbiao
Published: July 2023

Objective. To elucidate the mechanism by which LINC00174 promotes colon cancer progression by targeting the microRNA-2467-3p (miR-2467-3p)/enolase 3 (ENO3) axis to regulate inflammation and glycolysis. Methods. The expression of LINC00174 and ENO3 in colon cancer tissues, its relationship with survival rate, and correlation were analyzed using bioinformatic analysis. The effects of LINC00174 overexpression and silencing on the biological behavior of and inflammation in colon cancer cells were analyzed via transfection experiments. The target relationships between miR-2467-3p or LINC00174 and ENO3 were verified using sequence prediction and the dual-luciferase reporter assay, respectively. Furthermore, LINC00174- and/or miR-2467-3p-overexpressing cells were prepared to determine the effects on ENO3 protein levels and glycolysis. Finally, the effects of LINC00174 and/or miR-2467-3p overexpression on colon cancer, ENO3 protein levels, and inflammation were analyzed using a tumor-bearing mice model. Results. LINC00174 and ENO3 were overexpressed and associated with a lower survival rate. LINC00174 was positively correlated with ENO3 in colon cancer tissues. Furthermore, the overexpression of LINC00174 in colon cancer cell lines promoted the proliferation, migration, and invasion of colon cancer cells and inflammation but inhibited apoptosis. The overexpression of miR-2467-3p inhibited ENO3 protein levels, which was attenuated via LINC00174 overexpression. Furthermore, it inhibited the biological behavior of and inflammation and glycolysis in colon cancer cells and blocked their LINC00174-induced promotion. Moreover, using animal experiments, the regulatory effects of LINC00174 on tumor growth, ENO3 protein levels, and inflammation via miR-2467-3p were confirmed. Conclusion. LINC00174 promotes the glycolysis, inflammation, proliferation, migration, and invasion of colon cancer cells and inhibits apoptosis. The cancer-promoting mechanism of LINC00174 is related to targeting miR-2467-3p to promote ENO3 protein levels.
Supplementary Data from Genetic Modulation of BET1L Confers Colorectal Cancer Susceptibility by Reducing miRNA Binding and m6A Modification
Authors: Li Shuwei , Du Mulong , Xu Kaili , Ben Shuai , Zhu Tianru , Guo Mengfan , Xin Junyi , Zhu Lingjun , Gu Dongying , Zhang Zhengdong , Wang Meilin
Published: July 2023

Supplementary Figures 1-13
Supplementary Data from Genetic Modulation of BET1L Confers Colorectal Cancer Susceptibility by Reducing miRNA Binding and m6A Modification
Authors: Li Shuwei , Du Mulong , Xu Kaili , Ben Shuai , Zhu Tianru , Guo Mengfan , Xin Junyi , Zhu Lingjun , Gu Dongying , Zhang Zhengdong , Wang Meilin
Published: July 2023

Supplementary Tables 1-19
Supplementary Data from Periostin+ Stromal Cells Guide Lymphovascular Invasion by Cancer Cells
Authors: Null Jamie L. , Kim Dae Joong , McCann James V. , Pramoonjago Patcharin , Fox Jay W. , Zeng Jianhao , Kumar Pankaj , Edatt Lincy , Pecot Chad V. , Dudley Andrew C.
Published: July 2023

Data supplement
Supplementary Table 9_Pro metastatic pathways identified by differential expression singlePT setting from A Rare Subset of Primary Tumor Cells with Concomitant Hyperactivation of Extracellular Matrix Remodeling and dsRNA-IFN1 Signaling Metastasizes in Breast Cancer
Authors: Roda Niccolò , Cossa Andrea , Hillje Roman , Tirelli Andrea , Ruscitto Federica , Cheloni Stefano , Priami Chiara , Dalmasso Alberto , Gambino Valentina , Blandano Giada , Polazzi Andrea , Falvo Paolo , Gatti Elena , Mazzarella Luca , Luzi Lucilla , Migliaccio Enrica , Pelicci Pier Giuseppe
Published: July 2023

Supplementary Table reporting the Pro metastatic pathways identified by differential expression in singlePT setting
Supplementary Table 8_Genes identified by classification analysis in pro vs non metastatic clones from A Rare Subset of Primary Tumor Cells with Concomitant Hyperactivation of Extracellular Matrix Remodeling and dsRNA-IFN1 Signaling Metastasizes in Breast Cancer
Authors: Roda Niccolò , Cossa Andrea , Hillje Roman , Tirelli Andrea , Ruscitto Federica , Cheloni Stefano , Priami Chiara , Dalmasso Alberto , Gambino Valentina , Blandano Giada , Polazzi Andrea , Falvo Paolo , Gatti Elena , Mazzarella Luca , Luzi Lucilla , Migliaccio Enrica , Pelicci Pier Giuseppe
Published: July 2023

Supplementary Table reporting the genes identified by classification analysis in pro vs non metastatic clones
Supplementary Table 6_Gene modules analysis_GO and curated pathways associated to gene modules from A Rare Subset of Primary Tumor Cells with Concomitant Hyperactivation of Extracellular Matrix Remodeling and dsRNA-IFN1 Signaling Metastasizes in Breast Cancer
Authors: Roda Niccolò , Cossa Andrea , Hillje Roman , Tirelli Andrea , Ruscitto Federica , Cheloni Stefano , Priami Chiara , Dalmasso Alberto , Gambino Valentina , Blandano Giada , Polazzi Andrea , Falvo Paolo , Gatti Elena , Mazzarella Luca , Luzi Lucilla , Migliaccio Enrica , Pelicci Pier Giuseppe
Published: July 2023

Supplementary Table including Gene modules analysis and GO and curated pathways associated to gene modules
Supplementary Table 5_Marker genes all and some per cluster no cell cycle_GO and curated pathways per cluster no cell cycle from A Rare Subset of Primary Tumor Cells with Concomitant Hyperactivation of Extracellular Matrix Remodeling and dsRNA-IFN1 Signaling Metastasizes in Breast Cancer
Authors: Roda Niccolò , Cossa Andrea , Hillje Roman , Tirelli Andrea , Ruscitto Federica , Cheloni Stefano , Priami Chiara , Dalmasso Alberto , Gambino Valentina , Blandano Giada , Polazzi Andrea , Falvo Paolo , Gatti Elena , Mazzarella Luca , Luzi Lucilla , Migliaccio Enrica , Pelicci Pier Giuseppe
Published: July 2023

Supplementary Table including Marker genes (ALL and SOME settings) per cluster upon cell cycle regression, and GO and curated pathways per cluster upon cell cycle regression
Supplementary Table 2_Predictive power of genes and signatures_Patient cohorts GEO accession number from A Rare Subset of Primary Tumor Cells with Concomitant Hyperactivation of Extracellular Matrix Remodeling and dsRNA-IFN1 Signaling Metastasizes in Breast Cancer
Authors: Roda Niccolò , Cossa Andrea , Hillje Roman , Tirelli Andrea , Ruscitto Federica , Cheloni Stefano , Priami Chiara , Dalmasso Alberto , Gambino Valentina , Blandano Giada , Polazzi Andrea , Falvo Paolo , Gatti Elena , Mazzarella Luca , Luzi Lucilla , Migliaccio Enrica , Pelicci Pier Giuseppe
Published: July 2023

Supplementary Table including information about the predictive power of genes and signatures identified from metastatic clones and patient cohorts GEO accession numbers
Supplementary Table 10_Pro metastatic pathways identified by classification analysis from A Rare Subset of Primary Tumor Cells with Concomitant Hyperactivation of Extracellular Matrix Remodeling and dsRNA-IFN1 Signaling Metastasizes in Breast Cancer
Authors: Roda Niccolò , Cossa Andrea , Hillje Roman , Tirelli Andrea , Ruscitto Federica , Cheloni Stefano , Priami Chiara , Dalmasso Alberto , Gambino Valentina , Blandano Giada , Polazzi Andrea , Falvo Paolo , Gatti Elena , Mazzarella Luca , Luzi Lucilla , Migliaccio Enrica , Pelicci Pier Giuseppe
Published: July 2023

Supplementary Table reporting the Pro metastatic pathways identified by classification analysis
Table S3 from Caffeine Supplementation and FOXM1 Inhibition Enhance the Antitumor Effect of Statins in Neuroblastoma
Authors: Tran Gia-Buu , Ding Jane , Ye Bingwei , Liu Mengling , Yu Yajie , Zha Yunhong , Dong Zheng , Liu Kebin , Sudarshan Sunil , Ding Han-Fei
Published: July 2023

GO analysis of genes down-regulated by simvastatin
Supplementary Table S1 from Caffeine Supplementation and FOXM1 Inhibition Enhance the Antitumor Effect of Statins in Neuroblastoma
Authors: Tran Gia-Buu , Ding Jane , Ye Bingwei , Liu Mengling , Yu Yajie , Zha Yunhong , Dong Zheng , Liu Kebin , Sudarshan Sunil , Ding Han-Fei
Published: July 2023

qRT-PCR primers
Supplementary Table 2 from N6-Methyladenosine Promotes Translation of VEGFA to Accelerate Angiogenesis in Lung Cancer
Authors: Zhang Haisheng , Zhou Jiawang , Li Jiexin , Wang Zhaotong , Chen Zhuojia , Lv Ziyan , Ge Lichen , Xie Guoyou , Deng Guoming , Rui Yalan , Huang Hongbing , Chen Likun , Wang Hongsheng
Published: July 2023

Table S2
Supplementary Table 1 from N6-Methyladenosine Promotes Translation of VEGFA to Accelerate Angiogenesis in Lung Cancer
Authors: Zhang Haisheng , Zhou Jiawang , Li Jiexin , Wang Zhaotong , Chen Zhuojia , Lv Ziyan , Ge Lichen , Xie Guoyou , Deng Guoming , Rui Yalan , Huang Hongbing , Chen Likun , Wang Hongsheng
Published: July 2023

Table S1
Supplementary Data from N6-Methyladenosine Promotes Translation of VEGFA to Accelerate Angiogenesis in Lung Cancer
Authors: Zhang Haisheng , Zhou Jiawang , Li Jiexin , Wang Zhaotong , Chen Zhuojia , Lv Ziyan , Ge Lichen , Xie Guoyou , Deng Guoming , Rui Yalan , Huang Hongbing , Chen Likun , Wang Hongsheng
Published: July 2023

The detailed procedures of methods and eight figures are attached in supplementary.
Supplementary Data from Metabolic Reprogramming Driven by IGF2BP3 Promotes Acquired Resistance to EGFR Inhibitors in Non–Small Cell Lung Cancer
Authors: Lin Ziyou , Li Jingwei , Zhang Jian , Feng Weineng , Lu Jiaye , Ma Xiaofan , Ding Wen , Ouyang Shumin , Lu Jinjian , Yue Peibin , Wan Guohui , Liu Peiqing , Zhang Xiaolei
Published: July 2023

Supplementary Data
Supplementary Data from TGFβ Antagonizes IFNγ-Mediated Adaptive Immune Evasion via Activation of the AKT–Smad3–SHP1 Axis in Lung Adenocarcinoma
Authors: Ye Fan , Cai Zihao , Wang Boyu , Zeng Chenxi , Xi Yu , Hu Shaojie , Qu Rirong , Yuan Zhiwei , Yue Jiaqi , Tian Yitao , Wang Xue , Fu Xiangning , Li Lequn
Published: July 2023

Figure S
Table S4 from MEN1 Degradation Induced by Neddylation and the CUL4B–DCAF7 Axis Promotes Pancreatic Neuroendocrine Tumor Progression
Authors: Xu Junfeng , Ye Zeng , Zhuo Qifeng , Gao Heli , Qin Yi , Lou Xin , Zhang Wuhu , Wang Fei , Wang Yan , Jing Desheng , Fan Guixiong , Zhang Yue , Chen Xuemin , Chen Jie , Xu Xiaowu , Yu Xianjun , Ji Shunrong
Published: July 2023

No difference in DCAF7 expression levels in MEN1 wildtype vs mutant samples
Table S3 from MEN1 Degradation Induced by Neddylation and the CUL4B–DCAF7 Axis Promotes Pancreatic Neuroendocrine Tumor Progression
Authors: Xu Junfeng , Ye Zeng , Zhuo Qifeng , Gao Heli , Qin Yi , Lou Xin , Zhang Wuhu , Wang Fei , Wang Yan , Jing Desheng , Fan Guixiong , Zhang Yue , Chen Xuemin , Chen Jie , Xu Xiaowu , Yu Xianjun , Ji Shunrong
Published: July 2023

Gene mutation analysis identified in 50 patients with PanNETs