bluuebunny/crossref_metadata_2025 huggingface dataset:
Fit of Professional Setting and Regional Industrial Structure of Financial Colleges in the Greater Bay Area from Industry-Education Integration
Authors: Liu Shuyuan
Published: January 2022

Promoting the initiative and subjectivity of the two main bodies of schools and enterprises, as well as fully exploiting their synergy in practice, is a necessary prerequisite for reflecting the benefits of school-enterprise integration, and without it, China’s vocational education cannot improve the quality of professional and technical personnel training. Simultaneously, it allows for high-level economic and social development. This is also the focus and challenge of current vocational and technical education reform and innovation. We discovered that the integration of industry and education, as well as school-enterprise cooperation, has made significant progress in City C’s higher vocational colleges through questionnaire surveys and on-site interviews: the cooperation mechanism has been steadily established and innovated, the talent joint training model is diverse; the level of cooperation between the two parties has been continuously improved; the benefits of enterprise cooperation are complementary, and s The current situation is “schools are hot and enterprises are hot,” and both supply and demand are booming, contrary to the empirical view that the education industry integrates “schools are hot and enterprises are cold.” The engineering talent training industry-education integration collaboration model is to establish and combine multiple case studies to illustrate its application scenarios, and then propose the characteristics of the collaboration model and the level analysis of the collaboration elements based on different systems, dynamics, and dynamic training models. This study collects data through questionnaire surveys and investigates the synergistic elements using the fs QCA empirical analysis method. These synergistic elements can help the integration project be more effective. Reproducible guidance is provided by various types of integration projects. Finally, in light of the current state of talent training in the integration of production and education, this research suggests three countermeasures: government optimization of top-level design, hierarchical implementation of the collaborative main model, and project implementation scope to coordinate school and enterprise path selection.
Effectiveness and Adverse Effects of Risperidone in Children with Autism Spectrum Disorder in a Naturalistic Clinical Setting at a University Hospital in Oman
Authors: Al-Huseini Salim , Al-Barhoumi Ali , Al-Balushi Miad , Al-Hosni Amira , Al-Mahrouqi Tamadhir , Al-Mahrizi Balqees , Jaju Sanjay , Mirza Hassan
Published: January 2022

Objective. This study aimed at examining the effectiveness of treating children with autism spectrum disorder (ASD) who present with irritability, aggression, and disruptive behavior at the Sultan Qaboos University Hospital (SQUH) in Muscat, Oman, with risperidone, and to note any sex-based differences among this cohort. Method. This was a retrospective study conducted at the Department of Behavioral Medicine at SQUH over two years from January 2017 to December 2018. This study included all children aged 3 to 18 years attending the Child and Adolescent Mental Health Service (CAMHS) outpatient clinic with a diagnosis of ASD, based on the DSM-5 criteria, and comorbid disruptive behavior, who had been prescribed risperidone. Result. This study identified 95 ASD patients (72 males). Male patients’ BMI score after 12 months of risperidone treatment showed an increase by 0.62 (1.57 SD;

P
=
0.001

); however, there was no significant change among female patients. Somnolence was noted in 69.6% of female patients as compared to 34.7% of males (

P
=
0.003

). Among those with a family history of ASD, 5 out of 17 patients had treatment success (29.4%), whereas 70 out of 78 patients (90.0%) who did not have a similar history had successful treatment. Conclusion. In conclusion, low-dose risperidone monotherapy is effective and well tolerated among some children with ASD who present with disruptive behavior in a naturalistic clinical setting. However, we found that some of the side effects, such as weight gain and somnolence, were concerning.
High Doses of Silica Nanoparticles Obtained by Microemulsion and Green Routes Compromise Human Alveolar Cells Morphology and Stiffness Differently
Authors: De Matteis Valeria , Cascione Mariafrancesca , De Luca Agnese , Manno Daniela Erminia , Rinaldi Rosaria
Published: January 2022

Among all the inorganic nanomaterials used in commercial products, industry, and medicine, the amorphous silica nanoparticles (SiO2 NPs) appeared to be often tolerated in living organisms. However, despite several toxicity studies, some concerns about the exposure to high doses of SiO2 NPs with different sizes were raised. Then, we used the microemulsion method to obtain stable SiO2 NPs having different sizes (110 nm, 50 nm, and 25 nm). In addition, a new one‐pot green synthetic route using leaves extract of Laurus nobilis was performed, obtaining monodispersed ultrasmall SiO2 NPs without the use of dangerous chemicals. The NPs achieved by microemulsion were further functionalized with amino groups making the NPs surface positively charged. Then, high doses of SiO2 NPs (1 mg/mL and 3 mg/mL) achieved from the two routes, having different sizes and surface charges, were used to assess their impact on human alveolar cells (A549), being the best cell model mimicking the inhalation route. Cell viability and caspase‐3 induction were analyzed as well as the cellular uptake, obtaining that the smallest (25 nm) and positive‐charged NPs were more able to induce cytotoxicity, reaching values of about 60% of cell death. Surprisingly, cells incubated with green SiO2 NPs did not show strong toxicity, and 70% of them remained vital. This result was unusual for ultrasmall nanoobjects, generally highly toxic. The actin reorganization, nuclear morphology alteration, and cell membrane elasticity analyses confirmed the trend achieved from the biological assays. The obtained data demonstrate that the increase in cellular softness, i.e., the decrease in Young’s modulus, could be associated with the smaller and positive NPs, recording values of about 3 kPa. On the contrary, green NPs triggered a slight decrease of stiffness values (c.a. 6 kPa) compared to the untreated cells (c.a. 8 kPa). As the softer cells were implicated in cancer progression and metastasization, this evidence strongly supported the idea of a link between the cell elasticity and physicochemical properties of NPs that, in turn, influenced the interaction with the cell membrane. Thus, the green SiO2 NPs compromised cells to a lesser extent than the other SiO2 NPs types. In this scenario, the elasticity evaluation could be an interesting tool to understand the toxicity of NPs with the aim of predicting some pathological phenomena associated with their exposure.
The Evaluation of the Efficacy and Safety of Oral Colchicine in the Treatment of Knee Osteoarthritis: A Meta‐Analysis of Randomized Controlled Trails
Authors: Liu Weijie , Wang HaoChen , Su Chao , Kuang Shida , Xiong Yilin , Li Yusheng , Gao Shuguang
Published: January 2022

Objective. To evaluate the efficacy and safety of oral colchicine in the treatment for knee OA. Design. Meta‐analysis. Data Sources. Embase, PubMed (MEDLINE), the Cochrane Library, and Web of Science from inception to December 12, 2021. Study Selection. RCTs comparing colchicine with placebo for knee OA were included. No language or date restrictions were applied. Two authors abstracted data and determined quality. Outcomes of interest included VAS‐pain, WOMAC total index, and patient‐reported adverse events. Results. A total of five RCTs including 400 adult patients with OA met the inclusion criteria. The mean age of patients included was 56.05 years (range 21 to 79), and 80.87% were female. There was no difference in VAS‐pain (MD ‐1.49; 95% CI ‐3.15, 0.17; p = 0.08) when compared colchicine group with placebo group. And there was no statistically difference in WOMAC total index (std. MD ‐0.13; 95% CI ‐0.64, 0.38; p = 0.61) and patient report adverse events (RR 1.23; 95% CI 0.72, 2.11; p = 0.46). Conclusion. Colchicine is not currently recommended as a treatment for knee OA but might have insignificant effect. The conclusion is limited due to the variation in assessment indicator among available data. Further RCTs with larger sample size and longer follow‐up are needed to confirm the findings.
Application of Internet of Things Technology Based on Artificial Intelligence in Electronic Information Engineering
Authors: Zhang Haibo , Cheng Sining
Published: January 2022

Artificial intelligence is an intelligent system that can perform tasks in a complex and changeable environment without special manual intervention. It is a technology that can continuously optimize decisions and behaviors through machine learning. It is a portrayal of human intelligence in computers. The simple explanation is usually “artificial intelligence.” Since the invention of artificial intelligence, theory and technology have been continuously developed and its scope has also been continuously expanded. With the improvement of people’s rich and colorful material living standards, more and more areas of life where artificial intelligence products are used can be widely and conveniently accessed by people, but the abuse of artificial intelligence technology will also become the biggest public safety in the future. Artificial intelligence technology is used by some terrorists, making it more convenient for terrorist attacks. To this end, this article aims to study the artificial intelligence Internet of Things technology in electronic information engineering. It is hoped that the artificial intelligence Internet of Things technology can be better optimized and the technical means can be mastered and rationally used to improve people’s material living conditions and happiness. This article proposes how to better apply the artificial intelligence Internet of Things technology to electronic information engineering and analyze optimization schemes and early warning models to better simulate life and optimize information conditions. The experimental results of this paper are analyzed through model construction. Finally, this paper selects and uses 16 standard mechanics datasets to find that it is beneficial to the better application of artificial intelligence Internet of Things technology, which verifies the accuracy and overall applicability of the method.
Levosimendan Postconditioning Attenuates Cardiomyocyte Apoptosis after Myocardial Infarction
Authors: Xie Ying , Xing Zhengjiang , Wei Jie , Sun Xiaolin , Zhao Bin , Chen Yan , Geng Yue , Jia Zheng , Zou Honglin
Published: January 2022

Background. Levosimendan preconditioning has been shown to attenuate myocardial apoptosis in animal models. However, protective effects of levosimendan postconditioning against myocardial apoptosis following myocardial infarction (MI) have not been evaluated. Therefore, we investigated the effects of levosimendan postconditioning on myocardial apoptosis in MI rat models. Methods. In an anoxia/reoxygenation (A/R) model, H9c2 cells were pretreated with or without levosimendan postconditioning after which their apoptosis rates were assessed by flow cytometry, RT-qPCR, and western blot analyses. Then, postconditioning was performed with or without levosimendan in MI rat models. Myocardiocyte apoptosis was evaluated by echocardiography, TTC staining, TUNEL staining, immunohistochemical staining, RT-qPCR, and western blot analysis. Results. Levosimendan postconditioning inhibited H9c2 cell apoptosis in A/R models by elevating Bcl-2 while suppressing Caspase-3 and Bax at both mRNA and protein levels. Moreover, it improved cardiac functions and reduced the left ventricle infarction area in MI rat models. Compared to the MI control group, cardiomyocyte apoptosis rates in the levosimendan postconditioning group were low. The reduced cardiomyocyte apoptosis rates were associated with downregulation of Bax and Caspase-3 as well as with upregulation of Bcl-2 at mRNA and protein levels. Conclusions. Levosimendan postconditioning of MI rat models protected against cardiomyocyte apoptosis, implying that it is a potential strategy for preventing cardiomyocyte apoptosis in the treatment of cardiac dysfunction following MI.
An Analysis of the Motivation Mechanism of the Formation of Corporate Health Strategic Innovation Capability Based on the K-Means Algorithm
Authors: Shang Tingting
Published: January 2022

Improving enterprises’ independent innovation capability is critical to improving their competitive strength, industries’ independent innovation capability, industries’ international competitiveness, and countries’ independent innovation capability, as well as building an innovative country. It is now the era of strategic innovation. Many growing businesses are focused on strategic innovation, but they overlook the issue of ensuring that strategic innovation is implemented. Management and innovation are perennial themes in the long-term development of businesses. The most pressing issue in enterprises’ strategic innovation activities is how to combine their strategic direction with their superior ability and choose a strategic innovation path that is appropriate for their development. This paper uses data mining theory to establish the K-means clustering algorithm to identify the best strategic orientation of enterprise innovation strategic direction selection based on the existing advantages and capabilities of enterprises based on the analysis of the direction of enterprise strategic innovation.
Association between Circulating Antioxidants and Longevity: Insight from Mendelian Randomization Study
Authors: Yu Zhimin , Zhang Fangfang , Xu Chengkai , Wang Yanggan
Published: January 2022

Background. Antioxidants attracted long‐standing attention as promising preventive agents worldwide. Previous observational studies have reported that circulating antioxidants are associated with reduced mortality; however, randomized clinical trials indicate neutral or harmful impacts. The association of long‐term circulating antioxidant exposure with longevity is still unclear. Objectives. We aim to determine whether long‐term circulating antioxidant exposure is causally associated with longevity in the general population using the two‐sample Mendelian randomization (MR) design. Methods. Genetic instruments for circulating antioxidants (ascorbate, lycopene, selenium, beta‐carotene, and retinol) and antioxidant metabolites (ascorbate, alpha‐tocopherol, gamma‐tocopherol, and retinol) were identified from the largest up‐to‐date genome‐wide association studies (GWASs). Summary statistics of these instruments with individual survival to the 90th vs. 60th percentile age (11,262 cases and 25,483 controls) and parental lifespan (N = 1,012,240 individuals) were extracted. The causal effect was estimated using the inverse‐variance weighted method in the main analysis and complemented by multiple sensitivity analyses to test the robustness of results. Results. We found that genetically determined higher concentration of circulating retinol (vitamin A) metabolite was casually associated with a higher odds of longevity (OR, 1.07; 95% CI, 1.02–1.13; P < 0.01) and increased parental lifespan (lifespan years per 10‐fold increase: 0.17; 95% CI, 0.07–0.27; P < 0.01). Present evidence did not support a causal impact of circulating ascorbate (vitamin C), tocopherol (vitamin E), lycopene, selenium or beta‐carotene on life expectancy. No evidence was identified to show the pleiotropic effects had biased the results. Conclusions. Long‐term higher exposure to retinol metabolite is causally associated with longevity in the general population. Future MR analyses could assess the current findings further by utilizing additional genetic variants and greater samples from large‐scale GWASs.
Genome Sequencing of Hericium coralloides by a Combination of PacBio RS II and Next-Generation Sequencing Platforms
Authors: Zhang Caixia , Xu Lijun , Li Jian , Chen Jiansong , Yang Manjun
Published: January 2022

The fruiting bodies or mycelia of Hericium coralloides (H. coralloides) contain many physiologically active compounds that are used to treat various diseases, including cardiovascular disorders and cancers. However, the genome of H. coralloides has not been sequenced, which hinders further investigations into aspects, such as bioactivity or evolutionary events. The present study is aimed at (i) performing de novo sequencing of the assembled genome; (ii) mapping the reads from PE400 DNA into the assembled genome; (iii) identifying the full length of all the repeated sequences; and (iv) annotating protein-coding genes using GO, eggNOG, and KEGG databases. The assembled genome comprised 5,59,05,675 bp, including 307 contigs. The mapping rate of reads obtained from PE400 DNA in the assembled genome was 92.46%. We identified 2,525 repeated sequences of 14,23,274 bp length. We predicted ncRNAs of 48,895 bp and 11,736 genes encoding proteins that were annotated in the GO, eggNOG, and KEGG databases. We are the first to sequence the entire H. coralloides genome (NCBI; Assembly: ASM367540v1), which will serve as a reference for studying the evolutionary diversification of edible and medicinal mushrooms and facilitate the application of bioactivity in H. coralloides.
Modified Adaptive Fusion Scheme for Kalman Filter Based on the Hypothesis Test
Authors: Jiang Chen , Liu Wenkai , Li Hui , Xu Haijun
Published: January 2022

In the literature, the fading factor was constructed to overcome the shortage of model uncertainties in the Kalman filter. However, the a priori covariance matrix might be inflated abnormally by the fading factor once the measurement is unreliable. Thus, the fading factor may become invalid, and this problem is rarely discussed and tested. In this paper, squares of the Mahalanobis distance are introduced as the judging index, and the fading factor or the covariance inflation factor is adopted conditionally according to the hypothesis testing result. Therefore, an adaptive filtering scheme based on the Mahalanobis distance is put forward for the systems with model uncertainties. The proposed algorithm is implemented with the actual data collected by the integration of the global navigation satellite system (GNSS) and the inertial navigation system and INS (inertial navigation system) integrated systems (INS). For the systems with model uncertainties, experimental results demonstrate that the influences of both the outlying measurements and model errors are controlled effectively with the proposed scheme.
Differential Diagnosis of Hemophagocytic Syndrome by 18F-FDG PET/CT: A Meta-Analysis
Authors: Zhang Jun , He Bang , Wang Jian , Ying Caiyun , Zeng Lingfeng , Zheng Shiyi
Published: January 2022

Hemophagocytic syndrome (HPS) is a rare disease in clinical practice, and there are often cases of delayed diagnosis. At present, researchers have applied 18F-FDG PET/CT in the differential diagnosis of HPS, but no consensus has been formed. Therefore, this study aims to systematically evaluate the application value of 18F-FDG PET/CT in the diagnosis of HPS patients. PubMed, Embase, Cochrane Library, Chinese National Knowledge Infrastructure (CNKI), Wangfang database (Wangfang), and Chinese Biomedical Network (CBM) were searched to collect the relevant studies of 18F-FDG PET/CT in the diagnosis of HPS. Data from the articles were screened and extracted for meta-analysis using Stata16.0 software. A total of 10 retrospective studies, including 300 patients, were included in this meta-analysis. The meta-analysis results showed that the pooled sensitivity was 0.82 (95% CI: 0.67–0.95), specificity was 0.72 (95% CI: 0.51–0.86), positive likelihood ratio was 2.89 (95% CI: 1.46–5.75), positive likelihood ratio was 0.25 (95% CI: 0.12–0.54), diagnostic odds ratio was 2.89 (95% CI: 1.46–5.75), and AUC was 0.84 (95% CI: 0.81–0.87). The SUVmax in the liver, spleen, lymph nodes, and bone marrow of HPS patients was greater than 2.5, and the SUVmax in the spleen, lymph nodes, and bone marrow of malignant HPS patients was higher than that of benign HPS patients. The difference was statistically significant (

P
<
0.05

). According to the existing literature evidence, 18F-FDG PET/CT is an effective method for diagnosing HPS.
Implementation of Taguchi and Genetic Algorithm Techniques for Prediction of Optimal Part Dimensions for Polymeric Biocomposites in Fused Deposition Modeling
Authors: Kumar Raman , Chohan Jasgurpreet Singh , Singh Sandeep , Sharma Shubham , Singh Yadvinder , Rajkumar S.
Published: January 2022

Additive manufacturing has gained popularity among material scientists, researchers, industries, and end users due to the flexible, low cost, and simple manufacturing process. Among number of techniques, fused deposition modeling (FDM) is the most recognized technology due to easy operation, lower environmental degradation, and portable apparatus. Despite numerous advantages, the limitations of this technique are poor surface finish, dimensional accuracy, and mechanical strength, which must be improved. The present study focuses on the implementation of the genetic algorithm and Taguchi techniques to achieve minimum dimensional variability of FDM parts especially for polymeric biocomposites. The output has been measured using standard testing techniques followed by Taguchi and genetic algorithm analyses. Four response variables were measured and were converted into single variable with combination of different weightages of each response. Maximum weightage was given to width of FDM polymeric biocomposite parts which may play critical role in biomedical and aerospace applications. The advanced optimization and production techniques have yielded promising results which have been validated by advanced algorithms. It was found that layer thickness and orientation angle were significant parameters which influenced the dimensional accuracy whereas best fitness value was 0.377.
A Mental Disorder Prediction Model with the Ability of Deep Information Expression Using Convolution Neural Networks Technology
Authors: Huang Pufang
Published: January 2022

The psychological health education work of all universities is currently facing the same problem, despite the rapidly expanding scale of universities and the ever-increasing demand for students: there are few teachers engaged in this field, who cannot meet the urgent needs of the majority of students. Because of their mental illness, university students are unable to complete their studies in a timely manner, affecting their own development. One after the other, such occurrences occur. This paper uses the common mental disorder identification of university students as an example and builds a mental disorder identification model based on CNN. The model has the ability to learn on its own, allowing it to diagnose psychological disorders in university students and provide support for college psychological counselling and the psychological health team. However, because China currently pays little attention to the psychological health of this population, it is necessary to investigate and analyse the psychological health of university students at this time.
The Borderless Integration of Financial Management Innovation Using Big Data Analysis of Social Media
Authors: Tang Jinghui , Li Chunling , Fu Ying , Li Chu
Published: January 2022

This article mainly studies the innovation of borderless integrated financial management in big data social media in the era of wireless communication networks. For evaluating company A’s financial sharing capabilities, five first-level indicators are divided into four dimensions: quality, efficiency, cost, and safety, and are allowed to score the financial sharing center capabilities. First of all, system integration takes performance appraisal as the core, and through the establishment of a reasonable appraisal system, performance appraisal for the members of the financial team is carried out. Secondly, team members need to accept two-way leadership, two-way assessment, and two-way incentives from the finance and business departments. The experimental factors were analyzed, and the results showed that the cumulative variance contribution rate with common factors reached 89.339%. The importance of the first-level indicators is in order of process reengineering (27.08%), operation management (22.33%), information system (20.24%), personnel management (17.178%), and strategic planning (12.46%).
Construction of “Interactive” English Translation Teaching Model Based on Data-Driven Learning
Authors: Huang Yabin
Published: January 2022

With the growth of international trade, there is a greater demand for people with a diverse professional background and a high level of foreign language translation skills. This thesis covers the fundamental concepts and evolution of data-driven learning, well-known data-driven learning systems, common statistical parameters and analytical statistical methods of data-driven learning, and commonly used data-driven learning indexing software and its basic functions. A basic knowledge outline and data-driven learning thinking method are provided. Although English translation is widely used, there are still many flaws in professional training. In response to the current situation in which college English translation teaching is difficult to adapt to new requirements of college English teaching and talent training, it is proposed to combine multimedia technology and corpus, as well as support constructivist learning theory, data-driven learning theory, and autonomous learning theory, to create a “data-driven Learning (DLL) college English translation teaching model,” beginning with the teaching materials, teaching objectives, and a “data-driven Learning (DLL) college English translation teaching model,” starting from the teaching materials, teaching the impact of the model on college students’ translation learning. The results of the experiments show that this mode is associated with a significant improvement in students’ translation learning abilities. This model is shown to be effective when used in college English translation classes.
A Hierarchical Network with User Memory Matrix for Long Sequence Recommendation
Authors: Dong Jiawei , Sun Fuzhen , Wu Tianhui , Wu Xiangshuai , Zhang Wenlong , Wang Shaoqing
Published: January 2022

In many recommendation scenarios, the interactions between users and items are divided into a series of sessions according to the time interval. The traditional Recurrent Neural Network has some shortcomings, such as limited memory ability, inflexible access to memory data, and obvious deficiency in feature capture for long sequences. To deal with the mentioned issues, we propose a hierarchical network with user memory matrix, named HNUM2, which utilizes the memory network to store users' long-term and short-term interests. The memory network is more flexible to access memory data, which can solve the problem of insufficient capture of long sequence features. The proposed model is a hierarchical recommendation algorithm, which consists of two layers. The first layer is the session-level GRU model, which obtains the sequence characteristics of the current session to predict the next item. The second layer is the user-level memory network model which exploits the attention mechanism and incorporates the write module and read module. The experimental results on two public available datasets show that HNUM2 has achieved significant performance improvement comparing to the state-of-the-art methods.
The Burden of Likely Rubella Infection among Healthy Pregnant Women in Abakaliki, Ebonyi State, Nigeria
Authors: Ekuma Uchechukwu Onyeukwu , Ogbu Ogbonnaya , Oli Angus Nnamdi , Okolo Martin-Luther Oseni , Edeh Peter Anyigor , Al-Dahmoshi Hussein O. M. , Akrami Sousan , Saki Morteza
Published: January 2022

The first 140 days of pregnancy are critical as regards rubella virus infection because of the likelihood of a poor pregnancy outcome. This study was undertaken to investigate the likelihood of exposure to poor pregnancy outcomes due to seroprevalence of rubella among selected pregnant women attending Mile Four Hospital, Abakaliki, Ebonyi State, Nigeria. The seroprevalence of rubella immunoglobulin M (IgM) antibodies was investigated among pregnant women. A total of 187 sera samples collected from the women were screened for rubella virus IgM antibody using the enzyme-linked immunosorbent assay (ELISA). The results obtained were analyzed using SPSS. The chi square test was performed at a

P

value of 0.05 significance and at a 95% confidence interval. Of the 187 pregnant women, 35 (18.72%) were positive for the rubella virus. Pregnant women within 26–30 years of age had the highest prevalence (26.15%), while those aged 35–40 years had the least prevalence. Married women had the highest prevalence (20.0%), followed by singles (16.67%) and widows (15.38%), while divorced pregnant women recorded the least prevalence (9.20%). Pregnant women with no formal education were more predisposed to rubella virus (22.22%) infection compared to their educated counterparts. Occupationally, full-time housewives had the highest prevalence (24.26%). The infection rates seemed to wane as pregnancy advanced. The first trimester had the highest prevalence (21.88%), followed by the second trimester (18.84%) and the third trimester (17.44%). Pregnant women living in urban areas had higher IgM seroprevalence (20.18%) than those in rural areas (16.67%). Furthermore, grand multigravidas were more infected (22.73%) than primigravidas (14.52%) and multigravidas (20.39%). The seroprevalence of rubella in this study was high, and it calls for general surveillance and mass immunization of children and females of childbearing age in the area to help reduce the incidence of congenital rubella syndrome.
Evaluation on Distribution Characteristics of Pore Water Pressure within Saturated Pavement Structure Based on the Proposed Tire-Fluid-Pavement Coupling Model
Authors: Zheng Binshuang , Huang Xiaoming , Ma Jingwen , Hong Zhengqiang , Chen Jiaying , Zhao Runmin , Zhu Shengze
Published: January 2022

To investigate the flow characteristics of pore water in asphalt pavement and the variation law of the pore water pressure under vehicle loading, a novel method based on BA network and quartet structure generation set method was proposed to reconstruct the three-dimensional (3D) pavement model with pores. The permeability coefficient and the gradation curve were adopted to evaluate the reliability and stability of the random growth pavement model. Then, the tire-fluid-pavement coupling model was established with FLUENT 3D based on the fluid Mie–Gruneisen state equation. According to the built fluid-solid coupling model, the pressure-velocity coupled finite volume algorithm was applied to study the distribution of the pore water pressure in asphalt pavement. Results show that the pore water pressure in asphalt pavement decays periodically with time under vehicle loading. For different types of asphalt pavement, the pore water pressure in open-graded friction course (OGFC) pavement is the smallest during the whole process. Moreover, the peak values of the pore water pressure decrease in the order of asphalt concrete (AC) pavement, stone mastic asphalt (SMA) pavement, and OGFC pavement. The maximum negative value of the pore water pressure is generally less than 0.3 times the maximum positive values. As for saturated pavement pores, the pore water pressure is hardly affected by the water film thickness. The positive peak value of the pore water pressure increases on an approximate parabolic curve as the vehicle speed improves gradually, while the negative one remains largely unchanged. The results are expected to help reduce tire hydroplaning risk and provide guidance for the selection of asphalt mixtures of drainage asphalt pavement.
Healthcare and Scientific Treatment of Knee Osteoarthritis
Authors: Wang Huan , Ma Baoan
Published: January 2022

Knee osteoarthritis is a chronic degenerative disease companied with chronic knee pain and dysfunction. However, the etiology and pathogenesis of knee osteoarthritis were unclear. Currently, age, diet, trauma, obesity, and inheritance are the main risk factors. The major pathological hallmarks of knee osteoarthritis included subchondral bone sclerosis, articular cartilage degeneration, arthrosynovitis, and osteophyte. With the acceleration of the aging process in China, the treatment of knee arthritis and the methods to improve the quality of life have become the focus of medical staff. Currently, therapies in clinical practice include surgery and nonoperative treatment; however, the clinical effects of different individuals at different stages will still be very different. This article reviews the recent advances in the treatment of knee osteoarthritis from three aspects: nonsurgical treatment, surgical treatment, and modern new medical means.
Distributed Energy Management for Port Power System under False Data Injection Attacks
Authors: Shan Qihe , Zhang Xin , Zhang Qiongyue , Sun Qiuye
Published: January 2022

This paper investigates a distributed energy management strategy for the port power system under false data injection attacks. The attacker can tamper with the interaction information of energy equipment, penetrate the boundary between port information system and port power system, and cause serious operation failure of port energy equipment. Firstly, a hierarchical topology is proposed to allocate the security resources of the port power system. Secondly, by reconstructing the topological structure of the port information system, the robustness of the information system is improved, and the impact of false data injection attacks on the port power system is reduced, which realizes secure distributed energy management of the port power system. Finally, the simulation results show the effectiveness of the proposed strategy, and the defense capability of the port power system is improved.
Efficacy of NHP66 Bioactive Cage on Patients with Cervical Spine Injury in Short-Track Speed Skating
Authors: Yang Xinming , Liu Fei , Yin Yanlin , Zhang Peinan , Jia Yongli , Zhang Ying , Yao Yao , Tian Ye
Published: January 2022

Background. Short-track speed skating (STSS) is an extreme sport in pursuit of extreme speed and explosive force. In such a sport, once athletes fall down, they are susceptible to serious cervical spine injury (CSI) under the inertia of high-velocity movement. Nanohydroxyapatite/polyamide 66 (NHP66) bioactive cage is a high-tech product of nanotechnology in the medical field in recent years. With a structure similar to that of human cortical bone, NHP66 bioactive cage has extremely high toughness and strength, which tailors to the needs of STSS. Objective. This study mainly analyzed the therapeutic effect of NHP66 on patients with CSI in STSS, aiming to provide new opportunities for the treatment of this patient population. Methods. A total of 51 patients with CSI treated in our hospital were enrolled, including 19 cases of short-track speed skaters (observation group) and 32 cases of car accidents, falls from heights, or collision injuries (control group). The relevant surgical indicators (operation time, intraoperative blood loss, etc.), the incidence of adverse reactions, the Cobb angle of cervical lordosis before and after surgery, and the fusion segment height of the cage were observed and compared between the two groups. Postoperative pain was evaluated by the visual analog scale (VAS), improvement of spinal cord injury was assessed by the American Spinal Cord Injury Association (ASIA) Impairment Scale, and bone fusion, bone subsidence, and other motor functions were assessed by the Japanese Orthopaedic Association (JOA) score rating system. Results. The operation time, intraoperative blood loss, and incidence of adverse reactions in the observation group were significantly lower than those in the control group. The Cobb angle of cervical lordosis and the fusion segment height of cage increased significantly higher in both groups after surgery. In addition, the VAS scores of the observation group 2 h and 3 d after operation were significantly lower than those of the control group. In terms of improvement of spinal cord injury, ASIA and JOA scores in the observation group were significantly higher than those before treatment and in the control group. There was no significant difference in bone fusion activity between the two groups. Conclusions. In this study, it is found through experiments that NHP66 has higher safety and application value than autogenous iliac bone, confirming that NHP66 can achieve significant results as a cage for anterior cervical decompression and iliac bone graft fusion and internal fixation in short-track speed skaters after CSI.
Diagnostic Value of Contrast-Enhanced Ultrasound Image Features under Deep Learning in Benign and Malignant Thyroid Lesions
Authors: Xu Ping , Du Zusheng , Sun Long , Zhang Yan , Zhang Jingjing , Qiu Qin
Published: January 2022

This study aimed to analyze the application of the diagnostic model based on deep learning technology in the evaluation of thyroid contrast-enhanced ultrasound images and to provide a reference for the evaluation of benign and malignant thyroid. A diagnosis model of ultrasound images based on long- and short-term memory neural network (LSTM), C-LSTM, was proposed. The diagnostic method was compared with that based on support vector machine (SVM) and manual feature (MF), and it was applied to the diagnosis of thyroid contrast-enhanced ultrasound images. The results showed that the sensitivity, specificity, and accuracy of the C-LSTM model were greatly higher than those of SVM and MF, and the differences were considerable (

P
<
0.05

). The number of parameters and the calculation amount of the C-LSTM model were greatly lower than those of SVM- and MF-based diagnosis methods (

P
<
0.05

). The sensitivity, specificity, and accuracy of the C-LSTM model were greatly greater than those of the C-LSTM-0 model, while the amounts of parameters and calculations were greatly lesser than those of the C-LSTM-0 model (

P
<
0.05

). The numbers of benign tumors with contrast-enhanced ultrasound modes of no enhancement, no enhancement at early stage, and low enhancement were more than those of malignant tumors, while the numbers of high-enhancement tumors were greatly less than those of malignant tumors (

P
<
0.05

). The diagnostic area under the curve (AUC) of rise time (RT) ratio, time to peak (TTP) ratio, and mean transit time (mTT) ratio for malignant masses were large, which were 0.856, 0.794, and 0.761, respectively. RT ratio, TTP ratio, and mTT ratio were of high diagnostic sensitivity and specificity for malignant masses, while RT, TTP, and mTT were of low diagnostic sensitivity and specificity. In summary, the contrast-enhanced ultrasound images based on the deep learning C-LSTM model can effectively improve the diagnostic effect of benign and malignant thyroid masses. The image feature parameters RT ratio, TTP ratio, and mTT ratio were of good efficiency in diagnosing benign and malignant thyroid masses.
Physicochemical, Organoleptic Evaluation and Shelf Life Extension of Quinoa Flour-Coated Chicken Nuggets
Authors: El-Sohaimy Sobhy A. , Abd El-Wahab Miral G. , Oleneva Zilolakhon A. , Toshev Abduvali D.
Published: January 2022

The objective of the current study was to develop innovative quinoa-coated chicken nuggets by using quinoa flour instead of wheat flour and evaluate the impact of this substitution on the shelf life of the product and its nutritional and sensorial stability. The evaluation of the product has been done through physiochemical and microbiological analysis every three days of the storage period compared with negative control (NC) and positive control (BHT) through 24 days of cold storage (4 ± 1°C). During storage, the quinoa flour-coated chicken nuggets showed the best ability for delay of lipid oxidation with a lowest TBARS value of 1.07 mg MDA/kg compared to negative control (NC) (2.39 mg MDA/kg) and positive control (BHT) (2.00 mg MDA/kg). The same trend was observed in protein oxidation, where the quinoa flour was able to retard the protein oxidation better than negative and positive control (BHT) where it showed a carbonyl content of 6.44, 5.39, and 4.20 nmol carbonyl content/mg protein, respectively. The quinoa-coated chicken nuggets showed the lowest microbial load (5.8 × 103 cfu/g) compared to negative and positive controls (1.8 × 105 and 3.8 × 104 cfu/g) at 24 days of cold storage. These findings could be emphasized such that the utilization of quinoa flour in the coating of chicken nuggets is more effective in retarding lipid and protein oxidation, furthermore preventing microbial contamination during cold storage. All these findings might be playing a crucial role in the extending of the shelf life of the product in addition to giving the product a pleasant taste and flavor to consumers.
Muscle Mass and Inflammation in Older Adults: Impact of the Metabolic Syndrome
Authors: Buchmann Nikolaus , Fielitz Jens , Spira Dominik , König Maximilian , Norman Kristina , Pawelec Graham , Goldeck David , Demuth Ilja , Steinhagen-Thiessen Elisabeth
Published: January 2022

Background: Inflammatory processes are a cause of accelerated loss of muscle mass. Metabolic syndrome (MetS) is a highly prevalent age-related condition, which may promote and be promoted by inflammation. However, whether inflammation in MetS (metaflammation) is associated with lower muscle mass is still unclear. Methods: Complete cross-sectional data on body composition, MetS, and the inflammatory markers interleukin (IL)-1β, IL-6, IL-10, tumor necrosis factor (TNF), and C-reactive protein (CRP) were available for 1,377 BASE-II participants (51.1% women; 68 ± 4 years old). Appendicular lean mass (ALM) was assessed by dual-energy X-ray absorptiometry. Low muscle mass (low ALM-to-BMI ratio [ALMBMI]) was defined according to the Foundation for the National Institutes of Health (FNIH) Sarcopenia Project. Regression models, adjusted for an increasing number of confounders (sex, age, physical activity, morbidities, diabetes mellitus type II, TSH, albumin, HbA1c, smoking habits, alcohol intake, education, and energy intake/day), were used to calculate the association between low ALMBMI and high inflammation (tertile 3) according to MetS. Results: MetS was present in 36.2% of the study population, and 9% had low ALMBMI. In the whole study population, high CRP (odds ratio [OR]: 2.7 [95% CI: 1.6–4.7; p = 0.001]) and high IL-6 (OR: 2.1 [95% CI: 1.2–1.9; p = 0.005]) were associated with low ALMBMI. In contrast, no significant association was found between TNF, IL-10, or IL-1β with low ALMBMI. When participants were stratified by MetS, results for IL-6 remained significant only in participants with MetS. Conclusions: Among BASE-II participants, low ALMBMI was associated with inflammation. Low-grade inflammation triggered by disease state, especially in the context of MetS, might favor loss of muscle mass, so a better control of MetS might help to prevent sarcopenia. Intervention studies to test whether strategies to prevent MetS might also prevent loss of muscle mass seem to be promising.
Anesthetic Pharmacology of the Mint Extracts L-Carvone and Methyl Salicylate
Authors: Brosnan Robert J. , Ramos Kimberly , Aguiar Antonio Jose de Araujo , Cenani Alessia , Knych Heather K.
Published: January 2022

Introduction: Hydrocarbons with sufficient water solubility allosterically modulate anesthetic-sensitive ion channels. Mint extracts L-carvone and methyl salicylate water solubility exceeds modulation cutoff values for γ-amino butyric acid type A (GABAA) receptors, N-methyl-D-aspartate (NMDA) receptors, and type-2 voltage-gated sodium (Nav1.2) channels. We hypothesized that mint extracts modulate these channels at concentrations that anesthetize rats. Methods: Channels were expressed separately in frog oocytes and studied using 2-electrode voltage clamp techniques at drug concentrations up to 10 mM. Normalized current effects were fit to Hill equations. Mint compounds were formulated in a lipid emulsion and administered IV to rats. When unresponsive to the tail clamp, rats were exsanguinated, and plasma drug concentrations were measured. Results: Both mint compounds caused concentration-dependent inhibition of all channels except for methyl salicylate which inhibited GABAA receptors at low concentrations and potentiated at high concentrations. Plasma drug concentrations in anesthetized rats were 7.9 mM for L-carvone and 2.7 mM for methyl salicylate. This corresponded to ≥53% NMDA receptor inhibition and ≥78% Nav1.2 channel inhibition by both compounds and 30% potentiation of GABAA receptors by methyl salicylate. Conclusion: L-Carvone and methyl salicylate allosterically modulate cell receptor targets important to molecular actions of conventional anesthetics at concentrations that also induce general anesthesia in rats.
Cilioretinal Sparing Central Retinal Artery Occlusion from Giant Cell Arteritis
Authors: Kasimov Michelle , Popovic Marko M. , Micieli Jonathan A.
Published: January 2022

A 93-year-old woman presented with a 1-day history of sudden painless vision loss in her right eye with a background of new temporal headaches and jaw claudication. Dilated fundus examination of the right eye showed mild retinal whitening and edema throughout the right fundus with selective sparing in the distribution of the cilioretinal artery. A diagnosis of giant-cell arteritis (GCA) was made and confirmed with temporal artery biopsy. Oral prednisone was initiated and her vision improved to 20/200 in the right eye at 3-month follow-up. GCA-related cilioretinal artery sparing central retinal artery occlusion is rare and may have mild improvement with promt treatment.
Effect of SGLT2 Inhibitors on Risk of Stroke in Diabetes: A Meta-Analysis
Authors: Zhang Chunhui , Zhang Xian , Wang Peng , Zhu Qinghua , Mei Yongxia , Zhang Zhenxiang , Xu Hui
Published: January 2022

Background: The effect of sodium-glucose cotransporter 2 (SGLT2) inhibitors on reducing the risk of stroke in patients with type 2 diabetes mellitus (T2DM) remains unclear. Thus, we conducted this systemic review and meta-analysis of all relevant studies and trials to explore the role of SGLT2 inhibitors on the stroke prevention. Methods: The present study included articles published before October 2021 and searched in Web of Science, PubMed databases. We used STATA 12.0 software to compute hazard ratio (HR) and 95% confidence interval (CI). Results: Meta-analysis indicated that SGLT2 inhibitors showed no significant effects on risk of stroke in diabetes in randomized controlled trials with a fixed effects model (HR = 0.98; 95% CI: 0.88–1.09, I2 = 22.3%, p = 0.272). Compared to other glucose-lowering drugs (oGLD) and insulin, SGLT2 inhibitors alone significantly affected risk of stroke in diabetes in observational studies with a random effects model (HR = 0.87; 95% CI: 0.80–0.95, I2 = 72.2%, p < 0.001). Conclusions: In summary, this meta-analysis indicated that the use of SGLT2 inhibitors did not decrease the risk of stroke. And for some T2DM patients with high-risk factor of stroke, SGLT2 inhibitors therapy may be more suitable compared to some oGLD such as dipeptidyl peptidase-4 inhibitors. The results of this meta-analysis are necessary to be confirmed with further studies and clinical trials.