bluuebunny/crossref_metadata_2025 huggingface dataset:
Altered Ex Vivo NLRP3 Inflammasome Activation Is Associated with 28-Day Mortality in Septic Patients
Authors: Coudereau Rémy , Monneret Guillaume , Lukaszewicz Anne-Claire , Py Bénédicte F. , Argaud Laurent , Cour Martin , Bidar Frank , Gossez Morgane , Venet Fabienne
Published: December 2023

Sepsis is a life-threatening organ dysfunction caused by a dysregulated response to infection. In this context, the aberrant activation of the NLRP3 inflammasome has been documented mostly through the measurement of increased plasmatic concentrations of IL-1β and IL-18. At the cellular level, contradictory results have been published. However, no study has comprehensively monitored NLRP3 inflammasome activation at the basal level and after ex vivo reactivation of whole blood monocytes and neutrophils focusing on ICU patients with bacterial and viral sepsis, including a longitudinal analysis. Thus, we conducted a prospective longitudinal study, examining NLRP3 inflammasome functionality in COVID-19 ICU patients (n = 15) and bacterial septic shock patients (n = 17) during the first week of ICU hospitalization, compared with healthy donors. Using two whole-blood flow cytometry assays, we detected ASC speck-positive monocytes (i.e., monocytes presenting the polymerization of ASC proteins) and activated caspase-1 in polymorphonuclear cells as read-outs, both at baseline and following nigericin stimulation, a drug that forms pores and activates the NLRP3 inflammasome. Our findings showed that, at baseline and regardless of the type of infection, patients exhibited reduced ASC speck-positive monocytes and decreased activated caspase-1 in PMN compared to healthy volunteers. This decrease was prominent at day 0. Following nigericin stimulation, this reduction was also observed and persisted throughout the first week of hospitalization, irrespective of the cellular population or parameter being considered. Notably, at day 0, this diminished activation and response to stimulation of NLRP3 was associated with a higher 28-day mortality rate. Consequently, our observations highlighted a concurrent decline in both basal expression and ex vivo activation of the NLRP3 inflammasome in circulating myeloid cells from patients with bacterial and viral sepsis in association with increased mortality.
Investigating Local Patterns of Mumps Virus Circulation, Using a Combination of Molecular Tools
Authors: Gavilán Ana M. , Perán-Ramos Paula , Sanz Juan Carlos , García-Comas Luis , Pérez-Abeledo Marta , Castellanos Ana M. , Berciano José M. , López-Perea Noemí , Masa-Calles Josefa , Echevarría Juan E. , Fernández-García Aurora
Published: December 2023

Mumps is a vaccine-preventable disease caused by the mumps virus (MuV). However, MuV has re-emerged in many countries with high vaccine coverage. The World Health Organization (WHO) recommends molecular surveillance based on sequencing of the small hydrophobic (SH) gene. Additionally, the combined use of SH and non-coding regions (NCR) has been described in different studies, proving to be a useful complement marker to discriminate general patterns of circulation at national and international levels. The aim of this work is to test local-level usefulness of the combination of SH and MF-NCR sequencing in tracing hidden transmission clusters and chains during the last epidemic wave (2015–2020) in Spain. A database with 903 cases from the Autonomous Community of Madrid was generated by the integration of microbiological and epidemiological data. Of these, 453 representative cases were genotyped. Eight different SH variants and thirty-four SH haplotypes were detected. Local MuV circulation showed the same temporal pattern previously described at a national level. Only two of the thirteen previously identified outbreaks were caused by more than one variant/haplotype. Geographical representation of SH variants allowed the identification of several previously undetected clusters, which were analysed phylogenetically by the combination of SH and MF-NCR, in a total of 90 cases. MF-NCR was not able to improve the discrimination of geographical clusters based on SH sequencing, showing limited resolution for outbreak investigations.
Enhancement of SARS-CoV-2 Infection via Crosslinking of Adjacent Spike Proteins by N-Terminal Domain-Targeting Antibodies
Authors: Lusiany Tina , Terada Tohru , Kishikawa Jun-ichi , Hirose Mika , Chen David Virya , Sugihara Fuminori , Ismanto Hendra Saputra , van Eerden Floris J. , Li Songling , Kato Takayuki , Arase Hisashi , Yoshiharu Matsuura , Okada Masato , Standley Daron M.
Published: December 2023

The entry of SARS-CoV-2 into host cells is mediated by the interaction between the spike receptor-binding domain (RBD) and host angiotensin-converting enzyme 2 (ACE2). Certain human antibodies, which target the spike N-terminal domain (NTD) at a distant epitope from the host cell binding surface, have been found to augment ACE2 binding and enhance SARS-CoV-2 infection. Notably, these antibodies exert their effect independently of the antibody fragment crystallizable (Fc) region, distinguishing their mode of action from previously described antibody-dependent infection-enhancing (ADE) mechanisms. Building upon previous hypotheses and experimental evidence, we propose that these NTD-targeting infection-enhancing antibodies (NIEAs) achieve their effect through the crosslinking of neighboring spike proteins. In this study, we present refined structural models of NIEA fragment antigen-binding region (Fab)–NTD complexes, supported by molecular dynamics simulations and hydrogen–deuterium exchange mass spectrometry (HDX-MS). Furthermore, we provide direct evidence confirming the crosslinking of spike NTDs by NIEAs. Collectively, our findings advance our understanding of the molecular mechanisms underlying NIEAs and their impact on SARS-CoV-2 infection.
Groundwater Sustainability Assessment against the Population Growth Modelling in Bima City, Indonesia
Authors: Husna Abdullah , Akmalia Rizka , Rohmat Faizal Immaddudin Wira , Rohmat Fauzan Ikhlas Wira , Rohmat Dede , Wijayasari Winda , Alvando Pascalia Vinca , Wijaya Arif
Published: December 2023

Most of Indonesia’s population lives in areas with volcanic–alluvium geological characteristics. Based on the national hydrogeological map of the Indonesian Geological Agency, areas with volcanic–alluvium geological conditions have high groundwater potential and potential for groundwater damage. This study aims to test the resilience of groundwater areas with volcanic–alluvial characteristics to population growth. The MODFLOW groundwater model was built based on the site’s volcanic and alluvial geological conditions. This groundwater model was tested against pumping scenarios based on population water demand in 2011–2020 and then predicted population growth until 2030. The result shows that groundwater resilience in volcanic–alluvium locations has different characteristics based on lithology and population density characteristics. Urban areas that are mostly located in alluvium areas tend to have a linear groundwater decline pattern but have the sharpest groundwater decline gradient. In contrast, suburban areas in the alluvium-to-volcanic transition area initially experience exponential groundwater decline but change to linear, while rural areas located in volcanic areas that become the main development target have exponential groundwater decline characteristics. To counteract the continuous depletion of groundwater, researchers conducted a scenario for optimizing surface water use. Based on the results of the scenario, a 60% reduction in groundwater use is sufficient to stop continuous groundwater depletion. The results of this study can be used as a recommendation for long-term water resources management targets for volcanic and alluvium areas that are being targeted for development.
Decadal Trends in the Zooplankton Community of the Western Mediterranean
Authors: Fernandez de Puelles Maria Luz , Gazá Magdalena , Cabanellas-Reboredo Miguel , O’Brien Todd D.
Published: December 2023

Decadal trends in the zooplankton community were seasonally investigated in multiple monitoring transects of the western Mediterranean Sea during a period of increasing and record-high water temperatures. The transition area around the Baleares archipelago can be separated into two regions: the Alborán Sea and the Balearic Sea. Differences were found in the abundance and structure of the dominant zooplankton groups: the cladocerans and copepods. The highest zooplankton abundances were found during the stratified summer season, when cladoceran numbers peaked. However, copepods were more abundant during the winter. A marked seasonality was found in all groups and the dominant taxa: 114 species of copepods and 5 species of cladocerans were identified, but less than 8 species of copepods and 2 species of cladocerans dominated the populations. During the 2007–2017 study, warm and salty waters were observed in the Balearic Sea. In the Alborán Sea, cool and fresh waters were observed, along with a decline in chlorophyll. Irregular group and species trends were observed in both regions, exhibiting both increases and decreases depending on region and season. Trends differed, often oppositely, for the Alborán versus the Balearic Sea, with the transition region between them mirroring one or the other, switching with the seasons. The most dominant species, including Penilia avirostris and Clausocalanus arcuicornis, but also Evadne spinifera, C. lividus, C. furcatus, Paracalanus parvus, Acartia clausi, Centropages typicus, Subeucalanus monachus, and Calanus helgolandicus, are proposed as biological tracers to be used in further studies on climate and zooplankton community changes in the western Mediterranean Sea.
Paleoflood Reconstruction in the Lower Yellow River Floodplain (China) Based on Sediment Grain Size and Chemical Composition
Authors: Yang Jinsong , Liu Zhe , Yin Jinhui , Tang Liang , Zhao Hua , Song Lei , Zhang Peng
Published: December 2023

Alluvial sedimentary records in the North China Plain are essential in expanding flood history and understanding hazard patterns in the Yellow River basin where inundation risk exists and would probably increase under future global change. A detailed study of the Longwangmiao profile in the lower Yellow River floodplain reveals ancient flooding records over the late Holocene. Slackwater deposits are distinguished by typical sedimentary features and share similarities with those in the upper and middle Yellow River. This indicates that the traditional method can still be applied for paleoflood research beyond the gorge. However, unlike confined bedrock gorges, multiphase flood deposits of slackwater and overbank deposits represent different stages of flood events. These sedimentary assemblages recorded six flooding periods, further confirmed by the analysis of grain size and geochemistry. The profile was broadly subdivided into two flood-poor phases (3.7–6.7 ka, 0.8–1.7 ka) and three flood-rich phases (before 6.7 ka, 1.7–3.7 ka, after 0.8 ka) based on the dating results. Compared with the existing related research in the nearby area, the synchronous deposition cycles of floods and inter-floods are mainly controlled by the hydrodynamic conditions of the old Yellow River course. This study provides an analogue of paleoflood research in the lower Yellow River and similar alluvial plains. It explores the potential of interlinking paleoflood records in the whole Yellow River basin.
„Szívvel és lélekkel kell írni…”
Authors: Sajó Zalán
Published: December 2023

Martin Andersen Nexø, az akkor már idős dán író neve hirtelen vált ismertté Magyarországon a második világháború után. Nexø régóta baráti viszonyt ápolt kelet-európai kommunista politikusokkal, köztük Rákosi Mátyással. Számos utazást tett a Szovjetunióban, ill. az NDK-ban is, ahol végül letelepedett. Egy ízben Budapestre is ellátogatott, amiről a magyar sajtó részletesen beszámolt. Művei közül többet is lefordítottak magyarra. Leghíresebb regényének, a Ditte Menneskebarnnak tizenhárom magyar nyelvű kiadása jelent meg, az utolsó már a rendszerváltozás után.
Alles ist umgekehrt
Authors: Kádár-Karr Elisabeth
Published: December 2023

Die Edition der vorliegenden Leseprobe aus Elisabeth Kádár-Karrs Roman Alles ist umgekehrt entstand im Rahmen eines Seminars über die deutsch-ungarischen Beziehungen im Wintersemester 2023/24. Der Roman über das Budapest der 1910er Jahre gewann 1938 den für die im Exil tätigen Nachwuchsschriftsteller ausgeschriebenen Heine-Preis, erschien aber erst 1958 in einer von der Autorin stark überarbeiteten ungarischsprachigen Fassung mit dem Titel Gyönyörű ősz [Herrlicher Herbst].
Prevalence of anaemia, iron, and vitamin deficiencies in the health system in the Republic of Ireland: a retrospective cohort study
Authors: Clancy Conor Cian , Browne Leonard D , Gilligan Robert , Blake Ophelia , Stack Austin G
Published: December 2023

Background

Anaemia is a common but treatable condition that predicts adverse clinical outcomes. However, standards of anaemia management vary considerably.

Aim

To estimate the prevalence of anaemia and extent of screening for common underlying causes in the healthcare system in the Republic of Ireland.

Design & setting

We conducted a retrospective cohort study of 112 181 adult patients, aged ≥18 years, who had a full blood count performed in 2013, using data from the National Kidney Disease Surveillance System.

Method

The prevalence of anaemia was determined across demographic and clinical subgroups, according to World Health Organization (WHO) definitions. The proportion screened for iron, vitamin B12, and folate deficiency was determined within a 3-month follow-up period and the corresponding prevalence for each deficiency determined.

Results

The overall prevalence of anaemia was 12.0% (95% confidence interval [CI] = 11.8% to 12.2%) and was higher in women than men (13.2% versus 10.5%,
P
<0.001). Anaemia increased with advancing age (33.4% for those aged >75 years) and worsening kidney function (8.2%, 10.9%, 33.2%, and 63.8% for each estimated glomerular filtration rate [eGFR] categories >90, 60–89, 30–59 and <30 ml/min/1.73 m², respectively,
P
<0.001). After 3-months' follow-up, the proportion screened for iron deficiency was 11.2% based on transferrin saturation and 33.7% using serum ferritin. Screening for folate and B12 deficiency was 17.6% and 19.8%, respectively. Among screened patients, the prevalence of iron deficiency, B12, and folate deficiency was 37.0%, 6.3%, and 5.8%, respectively.

Conclusion

The burden of anaemia in the healthcare system is substantial especially for older patients and those with advanced kidney disease. Low screening rates for iron, B12, and folate deficiency are common and warrant quality improvement initiatives.
Efecto de la monetización de datos personales, provenientes de plataformas digitales, sobre el derecho a la privacidad
Authors: Alfonso Rojas Juan Ricardo , Loriet Diaz Sthefany , Ramírez Montúfar Alvaro Hernando
Published: December 2023

La monetización de datos personales provenientes de plataformas digitales recopila grandes cantidades de datos personales, desde preferencias de búsqueda hasta hábitos de compra. Esta recolección masiva puede llevar a la creación de perfiles detallados de usuarios, lo que representa una amenaza para la privacidad. Abordar estos problemas requiere un enfoque integral que combine regulaciones efectivas, prácticas éticas de las empresas y una mayor conciencia por parte de los usuarios sobre la importancia de proteger su privacidad en el entorno digital. De acuerdo a esta perspectiva se presenta un análisis sobre las nuevas formas de valorar los datos desde un componente económico y de sostenibilidad amparado en el derecho a la privacidad. Se construyó un análisis crítico de perspectiva. A manera de cierre se pudo establecer que la monetización de datos plantea desafíos legales y éticos en cuanto a la privacidad. Las leyes de protección de datos pueden no ser suficientes para abordar las complejidades de la recopilación y el uso de datos en el entorno digital, lo que deja a los usuarios en una posición vulnerable.
Wine tourism market research: Bringing the psychophysiology lab to the field
Authors: Pedro Bem-Haja  , Isabel Santos  , Cunha Diana , Elisabeth Kastenholz
Published: December 2023

Wine tourism is of growing academic and business interest, being also acknowledged as an important driver of rural development. Successful management and marketing decisions, matching visitor demand, requires solid market data. The questionnaire-based survey is one of the most popular approaches to collect quantitative data in tourism, with statistics playing an important role in supporting management decisions. One of the advantages of this data collection method is the possibility of obtaining large amounts of data from large numbers of tourists in a relatively easy, economic, broadly accessible and not too time-consuming way. However, given the subjective character of self-report responses, which are highly influenced by aspects such as social desirability, conscious data processing, validity and reliability of the measures used, many experts argue that questionnaires are insufficient to fully understand human behavior, attitudes and feelings. One way to obtain more objective data is through the use of psychophysiological indicators such as peripheral nervous system measurements, usually collected in the laboratory. The artificial character of this collection method (in the lab) is recognized, however, as its main disadvantage. In the present work, an innovative methodology (through peripheral nervous system measures) for collecting objective data in wine tourism contexts is proposed, thus overcoming the subjectivity of survey data and the possible bias resulting from the collection of objective measures in artificial laboratory contexts. Visitors at two Bairrada wineries wore small portable and wireless sensors to capture their electrocardiogram and electrodermal activity during guided visits to the premises. A small hand-held push button allowed them to register any moment they found particularly interesting or exciting. Signals were recorded on a smartphone by the experimenter, who was part of the visitor group, and who also registered different stimuli and activities along the visit. Additionally, psychophysiological data were complemented by an interview and survey data to enhance the interpretation of results. Preliminary results will be presented, illustrating the potential of this method to produce important and valid evidence in wine tourism, to inform stakeholders about their market and allow better management decisions.
The relationship of the change context with the resilience of hotels: Proposal for a Research Framework on Hotels during the Covid-19 crisis
Authors: Belias Dimitrios , Nikolaos Trihas
Published: December 2023

COVID-19 pandemic has brought many changes to the way that the tourist sector operates. Almost all of the tourist businesses are affected by the impact of the measures which were taken in order to deal with the effects of COVID-19. As a result there is high uncertainty on the internal and external environment that the management of tourist businesses would have to take into consideration. Indeed, the change context (internal and external environment) is unstable and this creates uncertainty. For this reason, this publication aims to develop a research framework which links the change context with the level of resilience of hotels during the COVID-19 crisis as well as the impact that this has on the performance. For this reason the paper recommends the use of Melián-Alzola et al (2020)’s research framework which is going to be enriched with the measure taken for COVID-19, which is its key contribution on the academia and the practitioners.
Q-sort Methodology - the systematic study of participant viewpoints in Social Research
Authors: Lopes Paula , Rodrigues Rosa , Varela Miguel
Published: December 2023

In social sciences research there are instruments made up of questions and that aim to ascertain opinions, behaviors and attitudes, aim to find out how the person would act in a given situation, instead of putting the person to the test. Although there are no right or wrong answers, there is a tendency to respond in a socially acceptable way, even if the answer does not correspond to reality. This problem can be circumvented through the Q-sort methodology that combines quantitative and qualitative data and analytical techniques that are not present in other methods. In this way, it consists of presenting participants with a set of statements on a given topic and asking them to classify them according to their opinion, according to a predefined distribution, which, in general, is approximately normal. This methodology forces participants to distribute the score among the items on the scale, thus avoiding the constraints associated with social desirability and the tendency to respond in the same way or always through the midpoint to different questions. Another advantage is that it provides linearity and near-normality to the scale, which makes it possible to compare subjects more easily with each other. Notwithstanding its advantages, Q-sort methodology also has negative points because forced-choice measures produce ipsative data that lead to distorted scales and problematic psychometric properties. As the data are obtained by ordering a set of items or by forcefully choosing one item over another, it is impossible to reach very high or very low values on all scales, which gives rise to a large number of negative values that, in turn, they result in an average correlation between the scales, which is also negative. In view of the above, it was considered pertinent to review the research carried out on the q-sort methodology, presenting its main advantages and disadvantages.
The Double Cognitive Bias of Mistakes: A Measurement Method
Authors: Kucharska Wioleta , Bedford Denise A.D. , Kopytko Aleksandra
Published: December 2023

There is no learning without mistakes. However, making mistakes among knowledge workers is still seeing shameful. There is a clash between positive attitudes and beliefs regarding the power of gaining new (tacit) knowledge by acting in new contexts and negative attitudes and beliefs toward accompanying mistakes that are sources of learning. These contradictory attitudes create a bias that is doubled by the other shared solid belief that “BOSSES NEVER MAKE MISTAKES.” The double cognitive bias of mistakes introduced by Kucharska and Bedford (2023) is assumed in this paper to harm organizational learning and collective intelligence development. To justify this point empirically in this paper, the authors propose a procedure enabling the measurement of the double cognitive bias of mistakes. Moreover, to validate the proposed method, authors empirically examine the influence of the KLC cultures’ synergy on knowledge sharing and organizational intelligence and compare obtained results with the effect observed for the sample free of the double bias of mistakes. Novelty: this study is the first to propose identifying the double bias of mistakes and empirically exposing its impacts.
Змішане навчання в закладах вищої педагогічної освіти України в умовах війни: аналітична записка
Authors: Котун К. , Лук’янова Л. , Баніт О. , Годлевська К. , Петренко Л. , Радомський І
Published: December 2023

В аналітичній записці висвітлено результати аналізу сучасного стану змішаного навчання в закладах вищої педагогічної освіти Україні в умовах війни; проведено діагностування рівня готовності викладачів педагогічних ЗВО (на прикладі науково-педагогічних працівників Вінницького державного педагогічного університету імені Михайла Коцюбинського) до організації змішаного навчання в умовах війни; виявлено ключові деструктивні наслідки війни для вищої педагогічної освіти. Теоретикоаналітична складова аналітичної записки виконана у межах реалізації проєкту (2022.01/0098) «Максимізація ефективності ресурсів змішаного навчання в закладах вищої педагогічної освіти у воєнний час та повоєнного відновлення України» за грантової підтримки Національного фонду досліджень України.
Здійснення змішаного навчання у ЗВО педагогічного профілю: програма тренінг-курсу
Authors:   Інститут педагогічної освіти і освіти дорослих імені Івана Зязюна НАПН України, Котун К. , Годлевська К. ,   Інститут педагогічної освіти і освіти дорослих імені Івана Зязюна НАПН України
Published: December 2023

Програма тренінг-курсу щодо максимізації ефективності психологічних, методичних і технологічних ресурсів змішаного навчання у воєнний час та повоєнного відновлення України для теоретичної і практичної підготовки викладачів-супервізорів у практичній реалізації змішаного навчання у закладах вищої педагогічної освіти України. Програма тренінг-курсу укладена у межах реалізації проєкту (2022.01/0098) «Максимізація ефективності ресурсів змішаного навчання в закладах вищої педагогічної освіти у воєнний час та повоєнного відновлення України» за грантової підтримки Національного фонду досліджень України.
ANALISIS DAMPAK PEMASARAN ONLINE TERHADAP PENINGKATAN PENJUALAN DAN RASIO-RASIO KEUANGAN
Authors: Nansi Maria Regina , Arbintarso Ellyawan Setyo , Rahayu Suparni Setyowati
Published: December 2023

Penelitian ini bertujuan mengetahui dampak pemasaran online yang dilakukan oleh UMKM Tahu Sehat Mas Khale pada tahun 2022 dalam upaya untuk meningkatkan omset penjualan dan profit. Hasil penelitian menunjukkan bahwa strategi baru yakni pemasaran tahu secara online tanpa meninggalkan pemasaran offline yang dilakukan Tahu Sehat Mas Khale di semester kedua tahun 2022 terbukti efektif menaikkan omset penjualan dan profit. Penjualan yang membaik ini membawa dampak positif juga ke rasio-rasio keuangan dan juga efisiensi perusahaan. Pemasaran secara online juga memberikan kemudahan dalam melakukan analisis bisnis karena mampu memberikan data yang sangat akurat. Saran yang direkomendasikan berdasarkan hasil penelitian ini adalah menggalakkan pemasaran online secara massif, meningkatan kemampuan pemasaran online dan pengoperasian e-commerce oleh UMKM, memberikan program-program promosi kepada pelangan, melakukan pengawasan produksi dengan baik agar tidak terjadi gagal produksi, dan bekerja sama dengan paguyuban pengrajin tahu setempat untuk mempertahankan kelangsungan suplai bahan baku kedelai.
SUPPLY CHAIN MANAGEMENT IN THE MEDICAL TOURISM NETWORKING SYSTEM: A REVIEW
Authors: Harahap Lia Adelina
Published: December 2023

The science development in the medicine field, brings the new methods and systems for health care and medical treatment, and also brings the convenience in transportation and communication. Accordingly, a new field of tourism emerges, that is the medical tourism. Medical tourism is an emerging tourism trend that has recently gained increasing popularity. The idea of medical tourism is that when individuals travel abroad to seek for medical services while at the same time have the intention of healing and relaxation. In practice, this particular field involves many stakeholders that collaborate each other to serve the customer. Consequently, the medical tourism industry depends mainly on the networking system. For that reason, one of the most beneficial management methods for coordinating and integrating these relevant parties in this particular field is through Supply Chain Management (SCM) in that SCM covers the management of numerous activities multiple role-players from various divisional functions and organizations. Accordingly, this paper aims to explore the system that supports medical tourism, particularly by searching the literature and sources of information related to this particular field. Several selected studies suggested a medical tourism supply chain conceptual model to develop better understanding of medical tourism system as a whole.
PENGARUH DIGITAL TAXATION (E-FILING, E-BILLING DAN E-FAKTUR) TERHADAP KEPATUHAN WAJIB PAJAK
Authors: Eddy Endah Purnama Sari , Carolina Verani , Jovi Christian
Published: December 2023

Peningkatan kepatuhan wajib pajak dari tahun ke tahun terus diharapkan oleh pemerintah. Seiring berjalannya waktu, teknologi digital juga terus mengalami kemajuan. Direktorat Jenderal Pajak (DJP) meluncurkan teknologi e-System (Electronic System) dalam upaya mengembangkan layanan perpajakan dengan kualitas yang lebih tinggi serta mempermudah pengawasan terhadap kepatuhan wajib pajak, diantaranya adalah e-Filing, e-Billing, dan e-Faktur. Penelitian ini bertujuan untuk memahami dan mengkaji  pengaruh digital taxation (e-Filing, e-Billing, dan e-Faktur) terhadap kepatuhan wajib pajak. Penelitian ini menggunakan metode survei dengan jumlah 100 responden yang mewakili 61.419 wajib pajak di Kota Bandung Kecamatan Bandung Kidul dan menerapkan teknik statistik inferensial dalam menganalisis datanya. Hasil penelitian ini menunjukkan bahwa digital taxation (e-Filing, e-Billing, dan e-Faktur) berpengaruh terhadap kepatuhan wajib pajak.
PENGARUH GAYA KEPEMIMPINAN TRANSFORMASIONAL, LINGKUNGAN KERJA, DAN MOTIVASI KERJA TERHADAP KEPUASAN KERJA PADA BANK NTT CABANG KALABAHI
Authors: Ningrum Dwi Mariana , Mongid Abdul , Julianti Emma
Published: December 2023

This study aims to determine whether transformational leadership style, work environment, and work motivation have a positive effect on employee job satisfaction. This research was conducted on employees of the Kalabahi Branch of Bank NTT who had worked for at least one year. The number of respondents was 54 employees using the purposive sampling method and the analytical technique used was the SPSS Statistics 26 multiple linear regression analysis technique. The results showed that there was a positive and significant influence of transformational leadership style, work environment, and work motivation on job satisfaction of Bank NTT employees Kalabahi Branch. This research is expected to be input for companies to be able to manage transformational leadership style, work environment, and better work motivation in order to provide greater job satisfaction for all employees of Bank NTT Kalabahi Branch so that employee performance can increase and company goals are well achieved.
JUMLAH UNIT USAHA DAN TENAGA KERJA TERHADAP NILAI TAMBAH INDUSTRI MANUFAKTUR BESAR SEDANG DI SUMATERA SELATAN
Authors: Novalia Nurkardina , Maulana Ahmad , Kurniawan Muhammad , Sudiyanto Totok , Puspita Santi
Published: December 2023

Sektor industri memiliki peran yang cukup besar dalam mendorong pertumbuhan ekonomi di Sumatera Selatan karena kemampuannya dalam menciptakan nilai tambah yang tinggi. Industri juga dapat membuka kesempatan untuk menciptakan dan memperluas lapangan pekerjaan sekaligus mengurangi angka pengangguran, yang berarti meningkatkan kesejahteraan serta mengurangi kemiskinan. Penelitian ini merupakan penelitian deskriptif kuantitatif. Data dalam penelitian ini adalah data yang diperoleh langsung melalui studi dokumentasi. Metode analisis yang digunakan dalam penelitian ini adalah metode penelitian deskriptif kuantitatif dengan pendekatan OLS. Sumber data diperoleh dari Badan Pusat Statistik (BPS) tahun 2023. Penelitian ini menunjukkan hasil bahwa tenaga kerja IBS tidak memiliki pengaruh yang positif terhadap nilai tambah industri Provinsi Sumatera Selatan sementara jumlah unit usaha ibs memiliki pengaruh yang positif namun tidak signifikansi terhadap nilai tambah industri Provinsi Sumatera Selatan.
Lipstick on a Pig? Critical Theory, Cognitive Science and Ontario’s New Language Curriculum.
Authors: Reich Stephen
Published: December 2023

This article investigates the responsiveness of Ontario’s new 2023 Language Curriculum to recommendations from the Ontario Human Rights Commission’s (2022) Right to Read Report. The report connected many students’ failure to master reading to the Ministry and Ontario teacher training programs’ neglect of cognitive science-based approaches (CSBAs) to reading, in favour of focusing on socio-cultural issues promoted by contemporary variants of Critical Theory (CT). Arguably, those variants distract elementary educators from their primary job of teaching children to read, and are pedagogically misguided, harmful to low socio-economic students, and hostile to science and evidence. Employing mixed methods, I compare the 2023 Curriculum to the OHRC’s curriculum and pedagogy recommendations, exploring differences in terminology used in both previous (2006) and new language curricula. I find that the Ministry has not in fact supplanted the terminology of CT with that of CSBAs. While the use of CSBA terminology doubled from 2006 to 2023, there was also a 355.24% increase in CT language, including an increase of 2,233.87% in use of identity, one of CT’s prime terms. I attribute these findings to an ideological disconnect between Ontario’s educational bureaucracy and its provincial government, which I argue is itself a product of Anglo-American isomorphism and bureaucratic agenda setting. These findings mirror those from previous research into the Ministry’s decades-long adoption of CT terminology, which I suggest is hindering efforts to promote reading mastery.
Plan for the Power Requirements of The Lights in the Fishing Boat Room Using LED Lights
Authors: Baya Nur , Suardi  , Wira Setiawan  , Mambang Rezalut T  , Aung Ye Kyaw
Published: December 2023

In the process of building a ship, electrical and lighting installation is one of the important components in the construction of a ship that concerns every room on the ship. This study conducted tests on the study of LED lights in the room above the ship. The method used is the zonal cavity method with division in one room into three parts, namely the height ceiling cavity (hcc), height room cavity (hrc), and height floor cavity (hfc) as well as determining the illumination value according to the standards set for each room. And the results obtained for the lamp power at TASA 22 by using the type of lighting with the LED type obtained a lighting electric load of 1.483 Kw. The results of this study provide for the fact that from various other research sources, it is concluded that LED lamps are better than TL lamps.
Strength Analysis on Yoke Single Point Mooring with Finite Element Method
Authors: Dianiswara Anggoronadhi , Rahmatikah Maya , Huda Abiyani Choirul
Published: December 2023

Analysis of stresses and deformations in the Single Point Mooring (SPM) yoke structure using the Finite Element Method (FEM) aims to determine and understand the stress distribution and deformation of the yoke, so that offloading activities comply with safety standards. The finite element method is a numerical modeling technique used to predict the behavior of a system by dividing an object into a number of elements that can be analyzed independently. This study uses 3 geometric models, namely single point mooring yoke geometry aged 0, 20, and 30 years. The results of the analysis will assist in understanding the stresses and deformations that occur in the SPM yoke structure. To simulate the tension of the ship during unloading, tensions of 75, 100, and 125 tons are represented. For each geometry, the greatest stress and deformation values found are 89 MPa for the 0-year model, 89.2 MPa for the 20-year model, 97.1 MPa for the 30-year model, respectively, and 0.08 mm for the 0-year model, 0.10 mm for the 20-year model, 0.11 mm for the 30-year model. This investigation demonstrates that the observed stress levels and deformations comply with safety standards.
GENUINE PROGRESS INDICATORS SEBAGAI PENDEKATAN ALTERNATIF MENUJU EKONOMI BERKELANJUTAN
Authors: LM Syuhada Ridzky  , La Ode Agus Said  , Siti Kadri Yanti Sari
Published: December 2023

This article aims to discuss how measuring economic growth such as GDP or GRDP in the context of a region no longer translates the reality of society. Using a literature review approach, this article explains how the Genuine Progress Indicator (GPI) can be the latest alternative towards a sustainable economy. There are two important findings from this analysis: first, GPI can act as a catalyst for a paradigm change in understanding economic growth holistically. Second, this change in mindset will be a reference for policymaking that supports the green economic agenda and accelerates the transition to renewable energy.
Possibility to determine the necessary length of WRC survey routes based on the area of hunting grounds
Authors: Kondratenkov I. A.
Published: December 2023

Article 36 of the Federal Law on Hunting and Conservation of Hunting Resources of 24.07.2009 No. 209-FZ (in the edition of the Federal Law of 22.12.2020 No. 455-FZ) stipulates that the accounting of hunting animals, in respect of which, in accordance with the above Federal Law, the limit of extraction and the quota of their extraction are established, is carried out on the basis of scientifically substantiated methods. Currently recommended by the authorized federal executive body and posted on the information and telecommunication network “Internet” on the official website of the authorized federal executive body is the Methodology of accounting for the number of hunting resources by the method of winter route counting, approved by the order of FGBU “Federal Research Center for Hunting” from November 14, 2022 no. 74. One of the main differences of the mentioned methodology is the algorithm of determining the minimum necessary total length of counting routes from the total area of hunting grounds located within the boundaries of the relevant hunting farms. However, in the open press there are no data on the conducted scientific studies justifying such an approach to determining the necessary length of survey routes. This was the basis for the present study. On the example of moose counting for some hunting farms of Saratov region the possibility of objective determination of the minimum necessary total length of counting routes depending on the total area of hunting grounds located within the boundaries of these farms was checked. The results of the study showed that such an approach in planning the volume of survey work is fundamentally flawed and cannot be considered scientifically justified, and since it takes the central place in the considered Methodology of counting the number of hunting resources by the method of winter route counting, the latter is scientifically unjustified. Consequently, its placement in the information and telecommunication network “Internet” on the official website of the authorized federal executive body contradicts the current legislation of the Russian Federation in the field of hunting and conservation of hunting resources.
Genetic differentiation within two large phylogroups of the common hamster (Cricetus cricetus) (Cricetidae, Rodentia), the boundary between them, and the population abundance
Authors: Feoktistova N. Yu. , Meschersky I. G. , Katsman E. A. , Meschersky S. I. , Gureeva A. V. , Kupriyanov V. P. , Bogomolov P. L. , Kropotkina M. V. , Davydov I. D. , Leonov A. G. , Surov A. V.
Published: December 2023

clarification. In the course of our specially organized expedition, tissue samples of the common hamster were collected in 12 regions of Russia and Kazakhstan, including areas at the potential border of the ranges of phylogroups “A” and “E” (“Europe”). Analysis of the nucleotide sequences of the cytb gene of the captured animals has shown that the boundary between these phylogroups runs between Turinsk and Yekaterinburg, further between Chelyabinsk and Kurgan, between Omsk and Tatarsk, and turns to the south, leaving the village of Turgai and the town of Temirtau in the west and the village of Bayanaul in the east. The structure of territorial genetic clades belonging to phylogroups “A” and “E” and the history of their formation were also analyzed. Most of the detected territorial clades were formed during the Late Pleistocene and Holocene. The population dynamics of phylogroups “A” and “E” was analyzed and its decline was shown in 8 of the 12 surveyed regions.
Concetto e realtà: il metodo della logica combinatoria in Hegel
Authors: Piccini Caterina
Published: December 2023

All’interno del grande problema metodologico sul rapporto tra Logica e Realphilosophie, Hegel identifica come realmente scientifica la comprensione della relazione tra Begriff e Vorstellung, in cui si tratta della rappresentazione come strumento categoriale dove il pensiero è immerso nell’alterità. A partire dalla necessità metodologica di un nesso sistematico tra rappresentazione e concetto, costitutivo di una logica combinatoria, il presente contributo si propone di comprendere quali ragioni sistematico-concettuali hanno portato Hegel nell’Enciclopedia delle scienze filosofiche in compendio (nelle sue edizioni più tarde: 1827,1830) a una rivalutazione della rappresentazione in quanto materia indispensabile e condizione necessaria per la conoscenza. La ripresa hegeliana della Vorstellung come sinonimo del logico immerso nell’alterità porterà a interrogarsi sul modo in cui la nozione di Übersetzung sia idonea a esprimere quella delicata azione svolta dalla coscienza nell’atto di far assumere ai propri contenuti una forma filosofica, consentendo di comprendere tutti i gradi della Realphilosophie come momenti di una logica della rappresentazione. Muovendo da tali osservazioni sarà necessario domandarsi se e in che senso la logica combinatoria possa essere considerata una semplice trasposizione del concetto nella rappresentazione o la messa in atto della componente concettuale che nella rappresentazione si volge all’esperienza.
 
Within the methodological problem of the relationship between Logic and Realphilosophie, Hegel identifies as truly scientific the understanding of the relationship between Begriff and Vorstellung. In that relationship, representation is treated as a categorical instrument where thought is immersed in otherness. Starting from the methodological necessity of a systematic link between representation and concept, constitutive of a combinatory logic, the present contribution aims to understand what systemic-conceptual reasons led Hegel in the Encyclopaedia of the Philosophical Sciences in Compendium (in its later editions: 1827,1830) to a re-evaluation of representation as an indispensable subject and necessary condition for knowledge. The Hegelian revival of Vorstellung as a synonym for the logical immersed in otherness will then lead to questioning how the notion of Übersetzung is suitable for expressing that delicate action performed by consciousness in the act of making its contents take on a philosophical form, making it possible to understand all the degrees of the Realphilosophie as moments of a logic of representation. On the basis of these observations, it will finally be necessary to ask whether and in what sense combinatorial logic can be considered as a simple transposition of the concept into representation or as the implementation of the conceptual component that in representation turns to experience.
STUDI POLA ALIRAN BAHAN PROSES PEMBEKUAN FILLET IKAN KAKAP MERAH (LUTJANUS CAMPECHANUS) DI PT. XYZ
Authors: Febry Pradana Hermawansyah Mochammad , Mubarok A.S.F.Q.R. , Kusuma Bayu , Wira Perdana Angga
Published: December 2023

Pola aliran bahan yang digunakan pada PT. XYZ bersifat tidak tetap. Hal ini dikarenakan keterbatasan ruang yang tersedia dan ragam produk yang dihasilkan cukup tinggi. Akan tetapi, keadaan tersebut tidak menghambat proses produksi dikarenakan tetap menjalankan SOP sesuai dengan yang ditetapkan. Penelitian ini bertujuan untuk mengetahui tipe layout dan tipe pola aliran bahan yang digunakan pada PT. XYZ. Metode penelitian dilakukan secara observasi dan wawancara yang kemudian disusun secara deskriptif. Hasil penelitian menunjukkan layout yang digunakan oleh PT. XYZ adalah product layout dengan pola aliran bahan pada proses pembekuan fillet ikan kakap merah berjenis zig-zag. Achievement Rate (AR) digunakan untuk mengetahui efektifitas produksi pada PT. XYZ. Hasil nilai AR berurutan dari minggu 1, 2, 3, dan 4 sebesar 96%, 96,4%, 82,1%, dan 98,6%. Saran yang dapat diberikan yaitu pola aliran bahan pada PT. XYZ dapat digunakan untuk mengevaluasi kinerja pekerja agar dapat mencapai target efektif produksi.
Surmounting Obstacles in STEM Education: An In-depth Analysis of Literature Paving the Way for Proficient Pedagogy in STEM Learning
Authors: Salvetti Fernando , Rijal Khaerul , Owusu-Darko Isaac , Prayogi Saiful
Published: December 2023

The modern educational system has recognized the significance of STEM as a vital component of students' preparation for a promising future. Consequently, there is a need for comprehensive research in STEM education, encompassing an understanding of its context, challenges, and strategies to overcome these obstacles. Ongoing research continues to focus on developing coherent studies in this area, particularly emphasizing effective STEM pedagogy, which has proven to positively impact students' learning outcomes. However, despite its potential, STEM education faces several challenges that could impede its progress. In the scope of this study, a thorough examination revealed at least six key challenges confronting, these challenges encompass: pedagogical challenges, curriculum-related issues, structural complexities, student apprehensions, assessment concerns, and the critical need for teacher support. These challenges, along with proposed solutions, are discussed in-depth in this article. It is worth noting that pedagogical challenges hold paramount importance, as teachers play a pivotal role in implementing successful STEM education in schools. As such, this article delves into various effective pedagogical aspects that can facilitate the advancement of STEM education and foster enhanced learning experiences for students. Several key aspects contribute to effective pedagogy in STEM education and learning, including: (a) cultivating an innovative learning environment that nurtures inquiry, experimentation, and critical thinking; (b) utilizing a diverse range of authentic learning methods and relevant educational resources; (c) facilitating a collaborative learning environment that encourages teamwork and knowledge sharing; (d) creating an inclusive learning environment that accommodates the diverse needs of students; and (e) encouraging continuous reflection on and improvement of teaching practices to optimize learning outcomes.
Trancatheter Aortic Valve Implantation in the Treatment of Heyde's Syndrome: A Case Report
Authors: Choukri Moulay Achraf , Bourzeg Khaoula , Hendy Ilias , Bouzerda Abdelmajid , Rafei Ayoub , Yahiaoui Hicham
Published: December 2023

Calcified aortic stenosis is the most common valvulopathy of the elderly. Its association with angiodysplasia and digestive bleeding is known as Heyde syndrome. This clinical case highlights the importance of the diagnosis of this syndrome whose complications can be fatal. The cessation of gastrointestinal bleeding is often remarkable after aortic valve replacement. Transcatheter aortic valve implantation (TAVI) can represents a good alternative to surgical valve replacement, especially in patients with high surgical risk. We report a case of 62-year-old patient, admitted for management of global cardiac decompensation on a tight aortic stenosis, confirmed by transthoracic echocardiography as well as a few episodes of syncope. He had a history of repeated lower digestive hemorrhages that required several transfusions. The evolution was marked by the appearance of heavy rectal bleeding on cecum angiodysplasia lesions confirmed by colonoscopy. The association of digestive bleeding and aortic stenosis raised the diagnosis of Heyde syndrome. An assay of von Willebrand factor (vWF) antigen, vWF binding collagen activity and their ratio confirmed a qualitative deficiency of vWF type 2A. The proposed treatment was TAVI because of the high surgical risk and the patient's refusal of the surgery. The evolution at 1 month post TAVI was marked by the improvement of hemostatic parameters related to the vWF and the disappearance of cardiac symptomatology. The cessation of gastrointestinal bleeding in Heyde's syndrome is conditioned by percutaneous aortic valve replacement in the high-risk surgical subject with a good clinical and biological evolution.