bluuebunny/crossref_metadata_2025 huggingface dataset:
Linking ecology and cognition: does ecological specialisation predict cognitive test performance?
Authors: Henke-von der Malsburg Johanna , Kappeler Peter M. , Fichtel Claudia
Published: December 2020

Variation in cognitive abilities is thought to be linked to variation in brain size, which varies across species with either social factors (Social Intelligence Hypothesis) or ecological challenges (Ecological Intelligence Hypothesis). However, the nature of the ecological processes invoked by theEcological Intelligence Hypothesis, like adaptations to certain habitat characteristics or dietary requirements, remains relatively poorly known. Here, we review comparative studies that experimentally investigated interspecific variation in cognitive performance in relation to a species’ degree of ecological specialisation. Overall, the relevant literature was biased towards studies of mammals and birds as well as studies focusing on ecological challenges related to diet. We separated ecological challenges into those related to searching for food, accessing a food item and memorising food locations. We found interspecific variation in cognitive performance that can be explained by adaptations to different foraging styles. Species-specific adaptations to certain ecological conditions, like food patch distribution, characteristics of food items or seasonality also broadly predicted variation in cognitive abilities. A species’ innovative problem-solving and spatial processing ability, for example, could be explained by its use of specific foraging techniques or search strategies, respectively. Further, habitat generalists were more likely to outperform habitat specialists. Hence, we found evidence that ecological adaptations and cognitive performance are linked and that the classification concept of ecological specialisation can explain variation in cognitive performance only with regard to habitat, but not dietary specialisation.
Use of insulin pump therapy is associated with reduced hospital-days in the long-term: a real-world study of 48,756 pediatric patients with type 1 diabetes
Authors: Auzanneau Marie , Karges Beate , Neu Andreas , Kapellen Thomas , Wudy Stefan A. , Grasemann Corinna , Krauch Gabriele , Gerstl Eva Maria , Däublin Gerhard , Holl Reinhard W.
Published: December 2020

In pediatric diabetes, insulin pump therapy is associated with less acute complications but inpatient pump education may lead to more hospital days. We investigated the number of hospital days associated with pump vs. injection therapy between 2009 and 2018 in 48,756 patients with type 1 diabetes < 20 years of age from the German Diabetes Prospective Follow-up Registry (DPV). Analyses were performed separately for hospitalizations at diagnosis (hierarchical linear models adjusted for sex, age, and migration), and for hospitalizations in the subsequent course of the disease (hierarchical Poisson models stratified by sex, age, migration, and therapy switch). At diagnosis, the length of hospital stay was longer with pump therapy than with injection therapy (mean estimate with 95% CI: 13.6 [13.3–13.9] days vs. 12.8 [12.5–13.1] days, P < 0.0001), whereas during the whole follow-up beyond diagnosis, the number of hospital days per person-year (/PY) was higher with injection therapy than with pump therapy (4.4 [4.1–4.8] vs. 3.9 [3.6–4.2] days/PY), especially for children under 5 years of age (4.9 [4.4–5.6] vs. 3.5 [3.1–3.9] days/PY).

Conclusions: Even in countries with hospitalizations at diabetes diagnosis of longer duration, the use of pump therapy is associated with a reduced number of hospital days in the long-term.

What is known:• In pediatric diabetes, insulin pump therapy is associated with better glycemic control and less acute complications compared with injection therapy.• However, pump therapy implies more costs and resources for education and management.What is new:• Even in countries where pump education is predominantly given in an inpatient setting, the use of pump therapy is associated with a reduced number of hospital days in the long-term.• Lower rates of hospitalization due to acute complications during the course of the disease counterbalance longer hospitalizations due to initial pump education
Human serum activates the tegument of female schistosomes and supports recovery from Praziquantel
Authors: Winkelmann Franziska , Frank Marcus , Rabes Anne , Koslowski Nicole , Schulz Cindy , Bischofsberger Miriam , Reisinger Emil C. , Sombetzki Martina
Published: December 2020

Schistosomiasis is one of the most devastating parasitic disease in the world. Schistosoma spp. survive for decades within the vasculature of their human hosts. They have evolved a vast array of mechanisms to avoid the immune reaction of the host. Due to their sexual dimorphism, with the female worm lying within the gynecophoric canal of the male worm, it is the male that is exposed to the immediate environment and the soluble parts of the host’s immune response. To understand how the worms are so successful in fending off the immune attacks of the host, comparative analyses of both worm sexes in human serum (with or without Praziquantel) were performed using scanning electron microscopy, transmission electron microscopy, and immunohistochemistry. Further, gene expression analyses of tegument-specific genes were performed. Following the incubation in human serum, males and females out of pairs show morphological changes such as an altered structure of the pits below the surface and an increased number of pits per area. In addition, female schistosomes presented a marked tuft-like repulsion of their opsonized surface. The observed resistance of females to Praziquantel seemed to depend on active proteins in the human serum. Moreover, different expression profiles of tegument-specific genes indicate different functions of female_single and male_single teguments in response to human serum. Our results indicate that female schistosomes developed different evasion strategies toward the host’s immune system in comparison to males that might lead to more robustness and has to be taken into account for the development of new anti-schistosomal drugs.
Selected components of physical fitness in rhythmic and artistic youth gymnast
Authors: Russo Luca , Palermi Stefano , Dhahbi Wissem , Kalinski Sunčica Delaš , Bragazzi Nicola Luigi , Padulo Johnny
Published: December 2020

Purpose

Rhythmic (RG) and artistic gymnastics (AG) are very popular female sports. These two disciplines share some common points but, at the same time, they display some relevant differences in terms of physical and technical characteristics. The aim of this study was as follows: (1) to clarify how gymnastic training background over the years could lead to the development and motor learning of the motor skills and (2) to highlight differences of conditional skills achieved by RG and AG athletes.

Methods

For these aims, 45 athletes were selected, belonging to three balanced groups: promotional (PG, n = 15), RG (n = 15), and AG (n = 15). Participants were tested for joints mobility, balance, explosive strength, speed, and endurance tests.

Results

Statistical analysis showed a good test–retest reliability of the measurements (ICC > 0.870) and some significant differences between PG, RG, and AG. RG showed higher values in joint mobility tests (coxo-femoral mobility, 166.7 ± 6.3°; sit and reach, 20.5 ± 1.9 cm; and scapulo-humeral mobility, 45.5 ± 4.4 cm) with respect to AG, while AG showed higher values in endurance (1626.7 ± 7.4 m), balance (4.33 ± 1.35 n/60 s), and explosive strength (164.1 ± 11.6 cm) compared to RG (p < 0.05).

Conclusion

RG and AG seem to be effective in enhancing different and sport-specific physical fitness and conditioning. RG enables, indeed, to develop more joints mobility whereas AG improves more strength, balance, and endurance. However, given the small sample size employed, these results should be replicated by further studies utilizing larger samples.
Effect of Nitriding Potential KN on the Formation and Growth of a “White Layer” on Iron Aluminide Alloy
Authors: Le Ngoc Minh , Schimpf Christian , Biermann Horst , Dalke Anke
Published: December 2020

This paper investigates the effect of nitriding potential under well-defined gas nitriding conditions on the formation and growth of a compound layer called “white layer” on a FeAl40 (with the composition of 40 at. pct Al) iron aluminide alloy. The nitriding potential was systematically varied in the range of 0.1 to 1.75 bar−1/2 at 590 °C for 5 hour nitriding time with an ammonia-hydrogen-nitrogen atmosphere. Characterization of the microstructure and phases formed within the white layer was performed using optical and scanning electron microscopy, X-ray diffraction (XRD), electron backscatter diffraction (EBSD), and glow discharge optical emission spectroscopy (GDOES). Experimental results indicated that the nitriding potential strongly influences morphology and crystal structure of the white layer. The nitride compound layer consists of the phases γ′-Fe4N, ε-Fe2-3N, and AlN. A mechanism is proposed for the formation and growth of the white layer, depending on the effect of the nitriding potential.
Tests for multivariate normality—a critical review with emphasis on weighted $$L^2$$-statistics
Authors: Ebner Bruno , Henze Norbert
Published: December 2020

This article gives a synopsis on new developments in affine invariant tests for multivariate normality in an i.i.d.-setting, with special emphasis on asymptotic properties of several classes of weighted$$L^2$$L2-statistics. Since weighted$$L^2$$L2-statistics typically have limit normal distributions under fixed alternatives to normality, they open ground for a neighborhood of model validation for normality. The paper also reviews several other invariant tests for this problem, notably the energy test, and it presents the results of a large-scale simulation study. All tests under study are implemented in the accompanying -package .
Influence of CO2 retention mechanism storage in Alberta tight oil and gas reservoirs at Western Canadian Sedimentary Basin, Canada: hysteresis modeling and appraisal
Authors: Rajkumar Perumal , Pranesh Venkat , Kesavakumar Ramadoss
Published: December 2020

Rapid combustion of fossil fuels in huge quantities resulted in the enormous release of CO2in the atmosphere. Subsequently, leading to the greenhouse gas effect and climate change and contemporarily, quest and usage of fossil fuels has increased dramatically in recent times. The only solution to resolve the problem of CO2emissions to the atmosphere is geological/subsurface storage of carbon dioxide or carbon capture and storage (CCS). Additionally, CO2can be employed in the oil and gas fields for enhanced oil recovery operations and this cyclic form of the carbon dioxide injection into reservoirs for recovering oil and gas is known as CO2Enhanced Oil and Gas Recovery (EOGR). Hence, this paper presents the CO2retention dominance in tight oil and gas reservoirs in the Western Canadian Sedimentary Basin (WCSB) of the Alberta Province, Canada. Actually, hysteresis modeling was applied in the oil and gas reservoirs of WCSB for sequestering or trapping CO2and EOR as well. Totally, four cases were taken for the investigation, such as WCSB Alberta tight oil and gas reservoirs with CO2huff-n-puff and flooding processes. Actually, Canada has complex geology and therefore, implicate that it can serve as a promising candidate that is suitable and safer place for CO2storage. Furthermore, injection pressure, time, rate (mass), number of cycles, soaking time, fracture half-length, conductivity, porosity, permeability, and initial reservoir pressure were taken as input parameters and cumulative oil production and oil recovery factor are the output parameters, this is mainly for tight oil reservoirs. In the tight gas reservoirs, only the output parameters differ from the oil reservoir, such as cumulative gas production and gas recovery factor. Reservoirs were modelled to operate for 30 years of oil and gas production and the factor year was designated as decision-making unit (DMU). CO2retention was estimated in all four models and overall the gas retention in four cases showed a near sinusoidal behavior and the variations are sporadic. More than 80% CO2retention in these tight formations were achieved and the major influencing factors that govern the CO2storage in these tight reservoirs are injection pressure, time, mass, number of cycles, and soaking time. In general, the subsurface geology of the Canada is very complex consisting with many structural and stratigraphic layers and thus, it offers safe location for CO2storage through retention mechanism and increasing the efficiency and reliability of oil and gas extraction from these complicated subsurface formations.
Oncocytic variant, a novel subtype of chromophobe renal cell carcinoma: a report of two cases and a literature review
Authors: Karashima Takashi , Kuroda Naoto , Taguchi Takahiro , Fukuhara Hideo , Kuno Takahira , Tamura Kenji , Hiroi Makoto , Inoue Keiji , Yamaguchi Tadanori
Published: December 2020

A novel variant of chromophobe renal cell carcinoma showing an oncocytic phenotype is proposed. Two new cases of this rare entity are presented and discussed along with six previous cases from our colleagues. A 76-year-old man and a 78-year-old man had a 3.4-cm and a 3.2-cm-diameter renal mass, respectively. On histopathological examination of surgical specimens, uniform eosinophilic cuboidal cells without a perinuclear halo growing in a tubular pattern were seen, and differential diagnosis from oncocytoma was necessary. Immunohistochemical staining for cytokeratin 7 and E-cadherin showed diffusely positive patterns in both, as in the previous reports. Although monosomy of chromosomes 7, 10, 13, and 17 was commonly observed in the previous reports, gains of chromosome 19 were observed in the two present cases. Immunohistochemical and cytogenetic approaches lead to exclusion of oncocytoma and the diagnosis of an oncocytic variant of chromophobe renal cell carcinoma.
Development and Social Implementation of Smartphone App Nige-Tore for Improving Tsunami Evacuation Drills: Synergistic Effects Between Commitment and Contingency
Authors: Yamori Katsuya , Sugiyama Takashi
Published: December 2020

This research explored how we can improve tsunami evacuation behavior, which has been a major social issue since the 2011 Great East Japan Earthquake and Tsunami. We introduce Nige-Tore, a smartphone app for supporting tsunami evacuation drills, which was developed within an interdisciplinary research framework. Nige-Tore serves as an effective interface tool that successfully visualizes the dynamic interactions between human actions (evacuation behavior) and natural phenomena (tsunami behavior). Drill participants can check, on their smartphone, the estimated inundation area of the approaching tsunami, along with their own current evacuation trajectory. The results of real-world trials using Nige-Tore show that the app is more powerful than conventional devices and methods that have been used in tsunami evacuation training, such as hazard maps and traditional drills that do not make use of any apps, because Nige-Tore provides an interface that enables commitment and contingency thinking—which at first glance appear to represent different orientations—to not only coexist but to synergize. “Commitment” (devotion or involvement) refers to the act of immersing oneself in and viewing as absolute one particular scenario or its potential to be actualized, given conditions in which infinite scenarios may be actualized, depending on the interactions between human systems and natural systems. “Contingency” thinking (an accidental or incidental state) refers to the act of relativizing and separating oneself from any particular scenario or its potential to be actualized, given the same conditions. The synergistic effect of “commitment” and “contingency” thinking also expands people’s capacity to cope with unexpected and unforeseen events.
Sport and sustainable development in Botswana: towards policy coherence
Authors: Moustakas Louis , Işık Arda Alan
Published: December 2020

There are increasing connections made between sport and sustainable development, both internationally and within Botswana’s national policies. However, these policy documents are vague and overly broad. There is no focus on where or how sport can be positioned to support sustainable development within Botswana’s unique national context. Using policy coherence as a theoretical framework, the goal of this paper is to analyse the current policy as well as propose national policy objectives and instruments to support sport’s contribution to sustainable development in Botswana. This paper relies on findings generated through semi-structured qualitative interviews, policy documents and academic literature. We propose that sport should be re-oriented to achieve objectives related to economic development, education, and health. Numerous concrete policy instruments are likewise suggested, including investing in small-scale sport infrastructure, public awareness campaigns and better sport educator training. Ultimately, these instruments enhance the coherence of the overall policy and create synergies by addressing multiple overarching objectives simultaneously.
The Question of 2047: Constitutional Fate of “One Country, Two Systems” in Hong Kong
Authors: Tu Yunxin
Published: December 2020

The history of Hong Kong is intertwined with British colonialism and China’s Hong Kong policies. This history offers unique and important lessons on the rise and fall of Hong Kong’s constitutional order. In accordance with the 1984 Sino-British Joint Declaration, China declares 12 basic policies regarding Hong Kong and has translated these into the 1990 Hong Kong Basic Law. It is generally held that “One Country, Two Systems” will be the main constitutional architecture of Hong Kong for 50 years, and it will remain basically unchanged even after 2047. However, there are obvious difficulties and enormous differences on the interpretation of Article 5 of the Hong Kong Basic Law concerning the true meaning of “unchanged for 50 years.” Recent years have witnessed the great need for deciphering the time-code of the Basic Law because the question of 2047 draws closer and closer to the central stage for the determination of Hong Kong’s constitutional future. This Article aims to provide legal analysis on Article 5 of Hong Kong Basic Law and the constitutional fate of Hong Kong toward 2047. It distinguishes all sorts of Article 5 interpretations into three broad categories: “Unchanged for 50 years” as international promise, “unchanged for 50 years” as political commitment, and “unchanged for 50 years” as constitutional obligation. Different approaches have been utilized for various constitutional interpretations. But all in all, the constitutional puzzles regarding “unchanged for 50 years” must be addressed within the framework of the temporality of the Basic Law in a fast-paced world. In order to maintain the constitutional stability and endurance, to secure the unamendability of “One Country, Two Systems” in 2047 will be the best blessing for Hong Kong in every possible way.
Antibiotic utilization variability among training services at an academic medical center: An observational study
Authors: Cinnamon Katherine A. , Schulz Lucas T , Sheehy Ann M. , O’Neill Sean M. , Lalik Edward , Fox Barry C.
Published: December 2020

Objective:

Evaluate the difference in antibiotic prescribing between various levels of resident training or attending types.

Design:

Observational, retrospective study.

Setting:

Tertiary-care, academic medical center in Madison, Wisconsin.

Methods:

We measured antibiotic utilization from January 1, 2016, through December 31, 2018, in our general medicine (GM) and hospitalist services. The GM1 service is staffed by outpatient internal medicine physicians, the GM2 service is staffed by geriatricians and hospitalists, and the GM3 service is staffed by only hospitalists. The GMA service is led by junior resident physicians, and the GMB service is led by senior resident physicians. We measured utilization using days of therapy (DOT) per 1,000 patient days (PD). In a secondary analysis based on antibiotic spectrum, we used average DOT per 1,000 PD.

Results:

Teaching services prescribed more antibiotics than nonteaching services (671.6 vs 575.2 DOT per 1,000 PD; P < .0001). Junior resident–led services used more antibiotics than senior resident–led services (740.9 vs 510.0 DOT per 1,000 PD; P < .0001). Overall, antibiotic prescribing was numerically similar between various attending physician backgrounds. A secondary analysis showed that GM services prescribed more broad-spectrum, anti-MRSA, and anti-pseudomonal antibiotics than the hospitalist services. GM junior resident–led services prescribed more broad-spectrum, anti-MRSA, and antipseudomonal therapy compared to their senior counterparts.

Conclusions:

Antibiotics were prescribed at a significantly higher rate in services associated with trainees than those without. Services led by a junior resident physician prescribed antibiotics at a significantly higher rate than services led by a senior resident. Interventions to reduce unnecessary antibiotic exposure should be targeted toward resident physicians, especially junior trainees.
Dietary quality is associated with reduced risk of diabetes among adults in Northern China: a cross-sectional study
Authors: Tan Siyue , Lu Haiwen , Song Ruier , Wu Jing , Xue Mingming , Qian Yonggang , Wang Wenrui , Wang Xuemei
Published: December 2020

In this study, we analysed the prevalence of diabetes in Inner Mongolia and explored the relationship between dietary patterns and diabetes using the Chinese Dietary Balance Index-16 (DBI-16). This study was a surveillance survey of Chronic Disease and Nutrition Monitoring among Chinese Adults in Inner Mongolia in 2015. Dietary data were collected using the 24-h dietary recall and weighing method over three consecutive days. Dietary quality was evaluated via the DBI-16. A generalised linear model was used to examine the associations between the DBI-16 and dietary patterns. The relationship between dietary patterns and diabetes was analysed using logistic regression. In Inner Mongolia, the diabetes prevalence was 8·5 % and the estimated standardised prevalence was 6·0 %. Four major dietary patterns were identified: ‘meat/dairy products’, ‘traditional northern’, ‘high cereal/tuber’ and ‘high-salt/alcohol’. Generalised linear models showed that the ‘meat/dairy product’ pattern was relatively balanced (βLBS = –1·993, βHBS = –0·206, βDQD = –2·199; all P < 0·05) and was associated with a lower diabetes risk (OR 0·565; 95 % CI 0·338, 0·945; P < 0·05) after adjusting for potential confounders. The other three dietary patterns (i.e. ‘traditional northern’, ‘high cereal/tuber’ and ‘high-salt/alcohol’) exhibited relatively unbalanced dietary quality and were unassociated with diabetes risk. Diabetes prevalence in Inner Mongolia was moderate. The dietary quality of the ‘meat/dairy product’ pattern was relatively balanced and was correlated with a decreased risk of diabetes prevalence, suggesting that dietary quality may help decrease diabetes prevalence and provide a suggestion for local dietary guidelines.
Microencapsulated pomegranate peel extract induces mitochondrial complex IV activity and prevents mitochondrial cristae alteration in brown adipose tissue in mice fed on a high-fat diet
Authors: Echeverria Francisca , Jimenez Patino Paula Andrea , Castro-Sepulveda Mauricio , Bustamante Andres , Garcia Concha Paula Andrea , Poblete-Aro Carlos , Valenzuela Rodrigo , Garcia-Diaz Diego F.
Published: December 2020

Pomegranate peel is an agro-industrial residue obtained after fruit processing with high total polyphenol (TP) content, making it an attractive by-product for its reuse. Pomegranate peel extract (PPE) and its bioactive compounds have shown positive effects on obesity models. Effects on favouring mitochondrial biogenesis and function have also been described. However, once phenolic compounds are extracted, their stability can be affected by diverse factors. Microencapsulation could improve PPE stability, allowing its incorporation into functional foods. Nevertheless, studies on the potential biological effects of PPE microparticles (MPPE) in obesity models are lacking. This study aims to evaluate the effect of MPPE on brown adipose tissue (BAT) mitochondrial structure and function and metabolic alterations related to obesity in mice fed a high-fat diet (HFD). PPE was microencapsulated by spray drying using inulin (IN) as a wall material and physically–chemically characterised. Eight-week-old male C57BL/6J mice (n40) were randomly distributed into five groups: control diet (CD), HFD, HFD + IN, HFD + PPE (50 mg/kg per d TP) and HFD + MPPE (50 mg/kg per d TP), for 14 weeks. A glucose tolerance test and indirect calorimetry were conducted. Blood and adipose tissue samples were obtained. MPPE supplementation prevented HFD-induced body weight gain (P< 0·001), fasting glycaemia (P= 0·007) and total cholesterol rise (P= 0·001). MPPE resulted in higher BAT mitochondrial complex IV activity (P= 0·03) and prevented HFD-induced mitochondrial cristae alteration (P= 0·02). In conclusion, MPPE prevented HFD-induced excessive body weight gain and associated metabolic disturbances, potentially by activating complex IV activity and preserving mitochondrial cristae structure in BAT in mice fed with a HFD.
Self-magnetic insulation in plasma opening switches
Authors: Loginov Sergey V.
Published: December 2020

The paper analyses the penetration of a magnetic field into the plasma bridge of nanosecond and microsecond opening switches. For switches with a conduction time of ~100 ns, simple formulae are derived to estimate the magnetic field velocity in collisionless and collisional plasmas. It is shown that in both cases this velocity is determined by the magnetic field rise rate to plasma density ratio raised to the power of 1/2. As the conduction time is increased to ~1

${\rm \mu}$

s, the field velocity starts to depend on the plasma aggregation by a magnetic piston. At the same time, irrespective of the conduction time, the electron flow velocity is limited by the radial drift velocity in crossed magnetic and polarization electric fields. Such a limitation suppresses the current channel conductivity with respect to the Spitzer value by a factor equal to the electron magnetization parameter raised to one or another power. On completion of the conduction phase, the rate of rise of the switch resistance is proportional to the electron drift velocity. The peak switch voltage obtained in calculations is compared with its values recorded in experiments on mega-ampere current switching. A procedure is also presented for calculating the switch parameters to obtain the maximum possible voltage in the phase of current cutoff.
A cross-cultural investigation of design and visual preference of signage information from Hong Kong and Pakistan
Authors: Iftikhar Hassan , Asghar Salman , Luximon Yan
Published: December 2020

Signage design has been considered critically important for wayfinding, being a functional medium of delivering environmental information. Complex institutional environments have several factors affecting the wayfinding, including but not limited to the design of information signage and its visual preference. Visual preferences of information design in wayfinding signage vary, depending on the cultural and individual differences. This study explores the variance in design and visual preferences of wayfinding signage and its influencing elements. Responses through online questionnaire have been accumulated by the participants from Hong Kong and Pakistan based on their design and visual preference of campus wayfinding signage. Questions were asked related to the user preferences for signage colour if in line with the institutional visual identity, mono or multi-colour coding of information and its visual volume. In total, 170 university students and visitors participated in the exploratory study from the respective countries. The results demonstrated that participants of Hong Kong preferred inline colours of signage, along with mono or less colour coding and detailed information. While the other group preferred attractive colours with multi-colour coding and less detailed wayfinding information with pictograms. Individual differences concerning age, literacy level and gender were also computed, however trivial differences have been recorded. This study suggests the need for detailed cross-cultural investigation concerning elements of signage design and visual preference to identify the drivers for culturally consistent university signage.
A new visual/inertial integrated navigation algorithm based on sliding-window factor graph optimisation
Authors: Liu Haiying , Wang Jingqi , Feng Jianxin , Wang Xinyao
Published: December 2020

Visual–Inertial Navigation Systems (VINS) plays an important role in many navigation applications. In order to improve the performance of VINS, a new visual/inertial integrated navigation method, named Sliding-Window Factor Graph optimised algorithm with Dynamic prior information (DSWFG), is proposed. To bound computational complexity, the algorithm limits the scale of data operations through sliding windows, and constructs the states to be optimised in the window with factor graph; at the same time, the prior information for sliding windows is set dynamically to maintain interframe constraints and ensure the accuracy of the state estimation after optimisation. First, the dynamic model of vehicle and the observation equation of VINS are introduced. Next, as a contrast, an Invariant Extended Kalman Filter (InEKF) is constructed. Then, the DSWFG algorithm is described in detail. Finally, based on the test data, the comparison experiments of Extended Kalman Filter (EKF), InEKF and DSWFG algorithms in different motion scenes are presented. The results show that the new method can achieve superior accuracy and stability in almost all motion scenes.
Designing, Implementing, and Managing a National Emergency Medical Service in Sierra Leone
Authors: Ragazzoni Luca , Caviglia Marta , Rosi Paolo , Buson Riccardo , Pini Sara , Merlo Federico , Della Corte Francesco , Vandy Matthew Jusu , Jambai Amara , Putoto Giovanni
Published: December 2020

Sierra Leone is one of the least developed low-income countries (LICs), slowly recovering from the effects of a devastating civil war and an Ebola outbreak. The health care system is characterized by chronic shortage of skilled human resources, equipment, and essential medicines. The referral system is weak and vulnerable, with 75% of the country having insufficient access to essential health care. Consequently, Sierra Leone has the highest maternal and child mortality rates in the world. This manuscript describes the implementation of a National Emergency Medical Service (NEMS), a project aiming to create the first prehospital emergency medical system in the country. In 2017, a joint venture of Doctors with Africa (CUAMM), Veneto Region, and Research Center in Emergency and Disaster Medicine (CRIMEDIM) was developed to support the Ministry of Health and Sanitation (MOHS) in designing and managing the NEMS system, one of the very few structured, fully equipped, and free-of-charge prehospital service in the African continent. The NEMS design was the result of an in-depth research phase that included a preliminary assessment, literature review, and consultations with key stakeholders and managers of similar systems in other African countries. From May 27, 2019, after a timeframe of six months in which all the districts have been progressively trained and made operational, the NEMS became operative at national level. By the end of March 2020, the NEMS operation center (OC) and the 81 ambulances dispatched on the ground handled a total number of 36,814 emergency calls, 35,493 missions, and 31,036 referrals.
IMMIGRATION, ENDOGENOUS SKILL BIAS OF TECHNOLOGICAL CHANGE, AND WELFARE ANALYSIS
Authors: Senel Gonca
Published: December 2020

This paper investigates the long-run effects of immigration on wages and welfare in a model with endogenous technology choice (ETC) where firms are allowed to choose their optimal skill intensity from a menu of available technologies. I embed the ETC framework into the Auerbach and Kotlikoff model (1987) that features a large set of overlapping generations, a rich collection of population dynamics, and a social security system. I calibrate the model to match with the U.S. data and evaluate the effect of ETC with the help of two experiments. In the first experiment, I increase the share of high-skilled immigrants and compare the wage and welfare predictions of the model with ETC to a standard model where the skill intensities in production technology are fixed. In the standard model, since the skill intensities are constant, increase in the supply of high-skilled labor leads to a decrease in high-skilled wages and an increase in low-skilled wages. On the other hand, in the model with ETC, negative supply-side effects are counterbalanced by an increase in the intensity of the more abundant high-skilled labor, leading to a smaller decrease in their wages. The discrepancy between wage predictions of these two models is also reflected in the welfare: while the model with ETC predicts an increase in both high- and low-skilled natives’ welfare, the standard model would predict a decrease in the welfare of the high skilled and a larger increase in the welfare of the low skilled. In the second experiment, I examine the effects of an increase in low-skilled immigration and find that in this case, since the initial production technology is low-skilled intensive, the ETC effects are smaller. These results imply that if ETC is ignored, both in the short run and long run, wage and welfare analyses of immigration will be incomplete, and even misleading.
Energetic Neutral Atoms From Jupiter's Polar Regions
Authors: Mauk B. H. , Allegrini F. , Bagenal F. , Bolton S. J. , Clark G. , Connerney J. E. P. , Gladstone G. R. , Haggerty D. K. , Kollmann P. , Mitchell D. G. , Paranicas C. P. , Roelof E. C. , Rymer A. M.
Published: December 2020

Energetic Neutral Atom (ENA) cameras on orbiting spacecraft at Earth and Saturn helped greatly to diagnose these complex magnetospheres. Within this decade, the European Space Agency's Jupiter Icy Moons Explorer will make ENA imaging a major thrust in understanding Jupiter's complex magnetosphere. The present polar‐orbiting Juno mission at Jupiter carries no ENA camera. But, the Jupiter Energetic‐particle Detector Instrument is sensitive to >50 keV ENAs, provided there are no local charged particles to mask their presence. Juno offers great service to interpreting past serendipitous and future dedicated ENA imaging with its orbit providing unique viewing perspectives. Here we report Juno observations of ENAs from Jupiter's polar regions. These ENAs likely arise from energetic ions that nearly precipitate in the main auroral regions and mirror magnetically within, and charge exchange with, Jupiter's upper atmosphere. Jupiter proves itself different from Saturn, as ENAs generated from precipitating ions were not identified there.
Super resolution microscopy and deep learning identify Zika virus reorganization of the endoplasmic reticulum
Authors: Long Rory K. M. , Moriarty Kathleen P. , Cardoen Ben , Gao Guang , Vogl A. Wayne , Jean François , Hamarneh Ghassan , Nabi Ivan R.
Published: December 2020

The endoplasmic reticulum (ER) is a complex subcellular organelle composed of diverse structures such as tubules, sheets and tubular matrices. Flaviviruses such as Zika virus (ZIKV) induce reorganization of ER membranes to facilitate viral replication. Here, using 3D super resolution microscopy, ZIKV infection is shown to induce the formation of dense tubular matrices associated with viral replication in the central ER. Viral non-structural proteins NS4B and NS2B associate with replication complexes within the ZIKV-induced tubular matrix and exhibit distinct ER distributions outside this central ER region. Deep neural networks trained to distinguish ZIKV-infected versus mock-infected cells successfully identified ZIKV-induced central ER tubular matrices as a determinant of viral infection. Super resolution microscopy and deep learning are therefore able to identify and localize morphological features of the ER and allow for better understanding of how ER morphology changes due to viral infection.
Evaluation of FGFR inhibitor ASP5878 as a drug candidate for achondroplasia
Authors: Ozaki Tomonori , Kawamoto Tatsuya , Iimori Yuki , Takeshita Nobuaki , Yamagishi Yukiko , Nakamura Hiroaki , Kamohara Masazumi , Fujita Kaori , Tanahashi Masayuki , Tsumaki Noriyuki
Published: December 2020

Achondroplasia is caused by gain-of-function mutations in FGFR3 gene and leads to short-limb dwarfism. A stabilized analogue of C-type natriuretic peptide (CNP) is known to elongate bone by interacting with FGFR3 signals and thus is a promising drug candidate. However, it needs daily administration by percutaneous injection. FGFR inhibitor compounds are other drug candidates for achondroplasia because they directly fix the mutant protein malfunction. Although FGFR inhibitors elongate the bone of model mice, their adverse effects are not well studied. In this study, we found that a new FGFR inhibitor, ASP5878, which was originally developed as an anti-cancer drug, elongated the bone of achondroplasia model male mice at the dose of 300 μg/kg, which confers an AUC of 275 ng·h/ml in juvenile mice. Although ASP5878 was less effective in bone elongation than a CNP analogue, it is advantageous in that ASP5878 can be administered orally. The AUC at which minimal adverse effects were observed (very slight atrophy of the corneal epithelium) was 459 ng·h/ml in juvenile rats. The positive discrepancy between AUCs that brought efficacy and minimal adverse effect suggests the applicability of ASP5878 to achondroplasia in the clinical setting. We also analyzed effects of ASP5878 in a patient-specific induced pluripotent stem cell (iPSC) model for achondroplasia and found the effects on patient chondrocyte equivalents. Nevertheless, cautious consideration is needed when referring to safety data obtained from its application to adult patients with cancer in clinical tests.
Incidence and risk factors of hepatocellular carcinoma in patients with hepatitis C in China and the United States
Authors: Yang Ming , Parikh Neehar D. , Liu Huixin , Wu Elizabeth , Rao Huiying , Feng Bo , Lin Andy , Wei Lai , Lok Anna S.
Published: December 2020

Hepatitis C virus (HCV) infection is the main cause of hepatocellular carcinoma (HCC) in the United States (US) and an increasingly common cause of HCC in China. We aimed to evaluate the incidence and risk factors of HCC in HCV patients in the US and China. 795 HCV RNA + patients without HCC from University of Michigan Health System (UMHS) in the US and 854 from Peking University Health Sciences Center (PUHSC) in China were prospectively followed for a median of 3.2 and 4.0 years, respectively. 45.4% UMHS and 16.2% PUHSC patients had cirrhosis. 57.6% UMHS and 52.0% PUHSC patients achieved SVR. 45 UMHS and 13 PUHSC patients developed HCC. Cumulative incidence of HCC at 5 years was 7.6% in UMHS and 1.8% in PUHSC cohort (P < 0.001). Ten patients not diagnosed with cirrhosis at enrollment but median APRI ≥ 2.0 developed HCC. Multivariate analysis showed age, gender, cirrhosis and APRI were predictors of HCC while study site and SVR were not. In this study of HCV patients, HCC incidence in the PUHSC cohort was lower than in the UMHS cohort, due to lower proportion of PUHSC patients with cirrhosis. APRI can identify risk of HCC among patients not diagnosed to have cirrhosis.
Destination of apyrene sperm following migration from the bursa copulatrix in the monandrous swallowtail butterfly Byasa alcinous
Authors: Konagaya Tatsuro , Idogawa Naoto , Watanabe Mamoru
Published: December 2020

Most male lepidopterans produce fertile eupyrene sperm and non-fertile apyrene sperm, both of which are transferred to the female in a spermatophore during mating. Apyrene sperm outnumbers eupyrene sperm and both sperm types migrate from the bursa copulatrix to the spermatheca after mating. While eupyrene sperm are maintained in the spermatheca until oviposition, the number of apyrene sperm decreases with time. It is unclear whether apyrene sperm disappear from all sperm storage organs in females because both sperm types are often observed in the spermathecal gland. To investigate this, the numbers of both sperm types were estimated in the spermatheca and spermathecal gland of female Byasa alcinous (a monandrous butterfly) 6, 12, 48, 96, and 192 h after mating terminated. Apyrene sperm arrived in the spermatheca earlier than eupyrene sperm; however, some eupyrene and apyrene sperm migrated to the spermathecal gland from the spermatheca at almost the same time. The number of apyrene sperm reached a peak 12 h after the termination of mating and then decreased with time in both the spermatheca and spermathecal gland. Our results suggest that the role of apyrene sperm might be completed early after arriving in the spermatheca of B. alcinous.
The retinal toxicity profile towards assemblies of Amyloid-β indicate the predominant pathophysiological activity of oligomeric species
Authors: Naaman Efrat , Ya’ari Sarah , Itzkovich Chen , Safuri Shadi , Macsi Flora , Kellerman Lior , Mimouni Michael , Mann Irit , Gazit Ehud , Adler-Abramovich Lihi , Zayit-Soudry Shiri
Published: December 2020

Amyloid-β (Aβ), reported as a significant constituent of drusen, was implicated in the pathophysiology of age-related macular degeneration (AMD), yet the identity of the major pathogenic Aβ species in the retina has remained hitherto unclear. Here, we examined the in-vivo retinal impact of distinct supramolecular assemblies of Aβ. Fibrillar (Aβ40, Aβ42) and oligomeric (Aβ42) preparations showed clear biophysical hallmarks of amyloid assemblies. Measures of retinal structure and function were studied longitudinally following intravitreal administration of the various Aβ assemblies in rats. Electroretinography (ERG) delineated differential retinal neurotoxicity of Aβ species. Oligomeric Aβ42 inflicted the major toxic effect, exerting diminished ERG responses through 30 days post injection. A lesser degree of retinal dysfunction was noted following treatment with fibrillar Aβ42, whereas no retinal compromise was recorded in response to Aβ40 fibrils. The toxic effect of Aβ42 architectures was further reflected by retinal glial response. Fluorescence labelling of Aβ42 species was used to detect their accumulation into the retinal tissue. These results provide conceptual evidence of the differential toxicity of particular Aβ species in-vivo, and promote the mechanistic understanding of their retinal pathogenicity. Stratifying the impact of pathological Aβ aggregation in the retina may merit further investigation to decipher the pathophysiological relevance of processes of molecular self-assembly in retinal disorders.
Eribulin as a first-line treatment for soft tissue sarcoma patients with contraindications for doxorubicin
Authors: Tsuchihashi Kenji , Kusaba Hitoshi , Yoshihiro Tomoyasu , Fujiwara Toshifumi , Setsu Nokitaka , Endo Makoto , Matsumoto Yoshihiro , Imajima Takashi , Shinohara Yudai , Ito Mamoru , Yamaga Satoru , Tanoue Kenro , Arimizu Kohei , Ohmura Hirofumi , Hanamura Fumiyasu , Yamaguchi Kyoko , Isobe Taichi , Ariyama Hiroshi , Nakashima Yasuharu , Akashi Koichi , Baba Eishi
Published: December 2020

Doxorubicin is a first-line therapy for patients with unresectable advanced soft tissue sarcoma (STS). However, because of cardiotoxicities, it is not used for patients with cardiac problems. Eribulin has exhibited efficacy for advanced STS in second- or later-line treatments. In the present study, we retrospectively analyzed the efficacy and safety of first-line eribulin therapy for patients with advanced STS unable to receive doxorubicin. Six of 28 patients who received eribulin as any line treatment received eribulin as a first-line treatment. The reasons for avoiding doxorubicin were as follows: cardiac problems for four patients and advanced age for two. Median progression-free survival (PFS) of the patients who received eribulin as first-line and, second or later-line therapy were 9.7 months (95% CI: 1.0-not reached) and 3.9 months (95% CI: 2.7–5.9), which were not significantly different. The reasons for discontinuation of eribulin were disease progression and adverse events (2 fatigue and 1 neuropathy) for three patients each. No treatment-related cardiotoxicity was observed. The findings of this study indicated that eribulin exhibits meaningful efficacy for the patients with contraindications for doxorubicin as a first-line treatment without cardiac adverse events. However, appropriate safety management is necessary because older patients are typically among those intolerable of doxorubicin.
Activation of PAR2 by tissue factor induces the release of the PTEN from MAGI proteins and regulates PTEN and Akt activities
Authors: Mohammad Mohammad A. , Greenman John , Maraveyas Anthony , Ettelaie Camille
Published: December 2020

Tissue factor (TF) signalling has been associated with alterations in Akt activity influencing cellular survival and proliferation. TF is also shown to induce signalling through activation of the protease activated receptor (PAR)2. Seven cell lines were exposed to recombinant-TF (rec-TF), or activated using a PAR2-agonist peptide and the phosphorylation state of PTEN, and the activities of PTEN and Akt measured. Furthermore, by measuring the association of PTEN with MAGI proteins a mechanism for the induction of signalling by TF was proposed. Short term treatment of cells resulted in de-phosphorylation of PTEN, increased lipid-phosphatase activity and reduced Akt kinase activity in most of the cell lines examined. In contrast, continuous exposure to rec-TF up to 14 days, resulted in lower PTEN antigen levels, enhanced Akt activity and increased rate of cell proliferation. To explore the mechanism of activation of PTEN by TF, the association of "membrane-associated guanylate kinase-with inverted configuration" (MAGI)1–3 proteins with PTEN was assessed using the proximity ligation assay and by co-immunoprecipitation. The interaction of PTEN with all three MAGI proteins was transiently reduced following PAR2 activation and explains the changes in PTEN activity. Our data is first to show that PAR2 activation directly, or through exposure of cells to TF releases PTEN from MAGI proteins and is concurrent with increases in PTEN phosphatase activity. However, prolonged exposure to TF results in the reduction in PTEN antigen with concurrent increase in Akt activity which may explain the aberrant cell survival, proliferation and invasion associated with TF during chronic diseases.