bluuebunny/crossref_metadata_2025 huggingface dataset:
Porto Murtinho (MS) – cidade canal: um meta-projeto para as cidades gêmeas da fronteira oeste do Brasil
Authors: Souza Rodrigo Mendes de , Delijaicov Alexandre Carlos Penha , Junqueira Juliana Villela , Carvalho Nicolas Xavier de , Santos Vitor Godinho Correa dos , Amaral Wagner Isaguirre do , Ahmed Juliana Ayako Okada , Azevedo Luiz Sampaio de Moura , Suguihara João Miguel , Karmann Lucas Barbosa , Oliveira João Gabriel Santos Lopes de
Published: August 2024

In recent years, a common South American agenda has focused on discussing integration axes via strategic infrastructure networks, such as the bi-oceanic corridor between Paranaguá and Santos in Brazil, and Antofagasta, Mejillones, Iquique, and Arica in Chile. By integrating borders, this development axis overlaps local and supranational relationss. Currently the road corridor, the only initiative of the IIRSA/COSIPLAN involving more than two countries, is still in progress and will be completed by 2025 with the construction of a bridge over the Paraguay River, connecting the cities of Carmelo Peralta, in Paraguay, and Porto Murtinho, in Brazil, thereby consolidating them as twin cities. This occurs in a context where over half of Mato Grosso do Sul’s exports are destined for China and two-thirds for the Asia-Pacific region, which is witnessing the strengthening of a new political-economic polarity. As a preliminary result of research conducted by four public universities, this article discusses a meta-project for Porto Murtinho, within the framework of desirable developments considering large infrastructure projects, having the flow of commodities and natural resources as the backdrop.
Muslim Neophytes in Venice: Enslaved and Free People, 1750–1824
Authors: Bonazza Giulia
Published: August 2024

This article focuses on continuity in the practice of the conversion of Muslims and its social implications in Venice in the period 1750–1824. Neophytes were people of other religious confessions who converted and were baptized as Catholics. Among neophytes of Muslim origin in Venice at this time were enslaved people, formerly enslaved individuals, and free men and women, as well as others of uncertain status. While the article discerns patterns of continuity in the practice of the conversion of Muslims and the wider experience of enslaved people in Venice, it argues that significant changes occurred after the fall of the Venetian Republic in 1797. These developments emerged in response to the shifting political climate and legal reforms of the Napoleonic period (1806–1814) and the post-1814 period in which Venice came under Austrian rule, culminating in a reduction in the number of neophytes and enslaved people in the city. The geographical origins of the neophytes ranged from the Ottoman Empire and its regencies to Eastern Africa, Sub-Saharan Africa, and the Atlantic. Sources from Venice’s Pius House of Catechumens reveal the types of work the neophytes performed and indicate how changes in ownership dictated slaves’ or former slaves’ trajectories before their arrival in Venice. The article also highlights how religious conversion from Islam to Catholicism was a watershed moment for individuals, one that had a major bearing on their living and working conditions and, in some cases, their social status.
New Revision of China’s Marine Environmental Protection Law
Authors: Zou Keyuan , Tan Ying
Published: August 2024

China’s Marine Environmental Protection Law was first adopted in August 1982 and came into force on 1 March 1983, and since then, it has gone through two revisions and three amendments. The latest revision in 2023 reflects China’s determination to further strengthen the protection of the marine environment and to prepare itself to meet new challenges and needs. This short article first provides a brief historical background of the Law and then evaluates some key changes in the 2023 revision. Finally, it highlights some features of the changes and pinpoints some concerns remaining in the Law even after the revision.
The French school of géoéconomie and its relation to géopolitique and géographie politique
Authors: Mamadouh Virginie
Published: August 2024

Exploring the possibilities of critical geoeconomics from a geographical perspective is an attempt to reclaim geoeconomics from the now established a-geographical and frequently uncritical uses of the term in International Relations. Something similar has been achieved before, from the 1990s onwards, when political geographers reclaimed – at least partially – geopolitics. The task is much harder however, because the geographical roots of this neologism have been forgotten and because the geo in geoeconomics remains underspecified. To explore alternatives, this essay reviews the French literature on geoeconomics and its relation to geopolitics and geography.
Video-Based Group-Values Affirmation Reduces Defensive Responses to Risk Messages
Authors: Arpan Laura , Yang Janet Z. , Shah Prerna , Lee Byeong Hyeon
Published: August 2024

This study evaluated an innovative, video-based, group-values affirmation against a traditional affirmation and a control group to demonstrate that the video induction increased group identity, which led to higher-level mental construal of the threat highlighted in risk messages about beef consumption. Consistent with self-affirmation theory, this higher-level mental construal resulted in lower message derogation, higher risk perception, and stronger intention to reduce beef consumption. These findings support the video-based approach to affirming group values.
Microangiopathic Hemolytic Anemia as a Paraneoplastic Syndrome in a Patient with Metastatic Gastric Cancer
Authors: Natsheh Shahd T , Abu Ihlayel Tuqa , Qasrawi Rawda , Alsalah Qusai A , Hammouri Ahmad G , Zughayyer Amer , Arafat Hasan
Published: August 2024

Cancer-associated microangiopathic hemolytic anemia (CA-MAHA) is a rare paraneoplastic syndrome. The most effective approach to treating CA-MAHA is to address the underlying malignancy. Documented cases of CA-MAHA are limited to fewer than 50 patients in the literature. Herein, we present a 51-year-old female patient who developed CA-MAHA as a complication of gastric adenocarcinoma. Despite receiving neoadjuvant and adjuvant chemotherapy for gastric cancer, the patient experienced disease progression with metastatic lesions in the liver, pancreas, and other sites. This report highlights the challenges in diagnosing and distinguishing CA-MAHA from other similar conditions such as disseminated intravascular coagulation (DIC), hemolytic uremic syndrome (HUS), thrombotic thrombocytopenic purpura (TTP), and rheumatological paraneoplastic syndromes. Additionally, it concludes that CA-MAHA is associated with a poor prognosis and limited clinical benefit from treatment, emphasizing the need for early diagnosis and effective management strategies.
The “negative” view of human nature: apologia for an unrealistic assumption
Authors: Raschi Francesco , Zambernardi Lorenzo
Published: August 2024

The “negative” view of human nature is customarily seen as a distinctive assumption of the classical realist approach. Such a controversial characterization is regarded either as a metaphysical conception belonging to the pre-scientific age of realism or as a dangerous self-fulfilling prophecy. Although the dark image of human nature has elicited fierce critiques, we contend that it needs to be reconsidered. The present article forms a kind of apologia for the “negative” view of human nature: not because of any belief that humans are all truly dangerous individuals, but for a purely political reason. Some of the most important mechanisms introduced in order to defend liberty, independence, domestic and international pluralism, and prevent power from concentrating in one point and thus becoming dominant, are themselves based on a view of the individual as problematic and potentially dangerous, whose behavior needs restraining by institutional and political measures. As we show in the article, it is no accident that the anthropological conception of human beings as dangerous is not the “private property” of political realism, but is shared by some illustrious fathers of liberalism such as Locke, Montesquieu, and Kant. It may be one of the ironies of history that the political philosophy whose manifesto proclaims the defense of freedom and individual rights should rest on a vision of the individual as potentially a dangerous bully, sometimes driven by greed and lust for power.
Group-Based Intervention Models in Treating Refugee Mental Health in High-Income Countries: A Systematic Review
Authors: Kirsch Jaclyn , Kitchens Katherine , Kerr Kristen , Sivakumaran Shamila
Published: August 2024

Refugees within the post-migration context experience higher rates of mental health symptoms due to a variety of pre- and post-migration factors. However, there is a lack of research in understanding best practices in culturally grounded interventions aimed at improving well-being outcomes. Recent research shows group interventions are a potential pathway to mental health treatment for refugees. This systematic review aimed to (1) assess best practices among group-based interventions within the refugee context, (2) provide literature-informed guidance on best practices within group-based interventions for this population, and (3) examine the impact of group-based interventions on the mental health outcomes of adult refugees in the post-migration context in high-income countries. A systematic literature search was conducted using Academic Search Complete, Social Work Abstracts, and PsycINFO. A total of 2,243 studies were identified, with 19 meeting the inclusion criteria to be from a peer-reviewed journal article; be published from 2003 to 2023; be written in English; have a study population of refugees in the post-resettlement context in a high-income country; include a group-based intervention model; and be quantitative or mixed methods. Results demonstrated that group-based interventions improve mental health symptoms, including post-traumatic stress disorder, depression, and anxiety. Studies varied on their use of culturally grounded mechanisms in developing and implementing interventions. Future research is needed to understand the longitudinal impacts of group-based interventions on mental health and better support current practices to facilitate access to intervention implementation.
Reverse Total Shoulder Arthroplasty in the Setting of an Intramuscular Lipoma With Extension Into the Glenoid: A Case Report
Authors: Griswold B. Gage , DeFoor Mikalyn T. , Steflik Michael J. , Parada Stephen A.
Published: August 2024

Glenoid bone loss from an infiltrating intramuscular lipoma causing erosive changes is a rare occurrence. A 71-year-old woman with symptomatic rotator cuff arthropathy in the setting of an intramuscular infiltrating lipoma and secondary glenoid bone loss was treated with single-stage tumor excision and reverse total shoulder arthroplasty (rTSA) using an injectable, hard self-setting calcium phosphate as structural bone graft substitute. The patient demonstrated excellent clinical and radiographic outcomes at 2-year follow-up. Infiltrating lipomas resulting in functional rotator cuff arthropathy and erosive osseous glenoid changes are exceedingly rare, yet significant glenoid bony defects present a challenge in the setting of shoulder arthroplasty. This report describes the use of structural bone graft substitute for the management of a glenoid bone defect from a rare case of an intramuscular infiltrating lipoma, while maintaining excellent improvement in functional outcomes and pain after rTSA.
Successful treatment of hemophagocytic intravascular large B-cell lymphoma with CNS involvement with BTK inhibitor combined with rituximab and high-dose methotrexate
Authors: Shao Fangfei , Su Wei , Zhao Xiujie , He Jianping , Wang Xiaofen , Guo Feng , Xiao Haowen
Published: August 2024

This is a case of hemophagocytic intravascular large B-cell lymphoma (IVLBCL) with central nervous system (CNS) involvement. Although R-CHOP chemotherapy regimen has been shown significant improvement in survival rate. The prognosis and outcomes remain unsatisfactory, which is identified as outstanding challenges and need solutions. Gene and molecular profiling studies may provide new therapeutic strategies, especially the BCR/TLR/IL-1R/NF-κB signaling pathway in IVLBCL. Here, we treated the hemophagocytic IVLBCL CNS-involved patient with the Bruton tyrosine kinase inhibitor (BTKi) to block NF-κB pathway, and indicated that the second-generation BTKi zanubrutinib-based treatment was feasible and efficient.
Positive Psychology Intervention (PPI) Program for Persons Who Use Drugs (PWUDS): A Pilot Study
Authors: Masanda Argel B.
Published: August 2024

Building on the premises of Positive Psychology, this undertaking conducted a pilot study of the designed 14-session Positive Psychology Intervention (PPI) program established based on the character strengths and virtues (CSV) of persons who use drugs (PWUDs) to assess its usefulness, delivery details, and impacts. Conducted in one of the biggest Drug Abuse Treatment and Rehabilitation Center in the Philippines, 24 PWUDs were randomly selected by the program staff to participate in its pilot run while securing all necessary ethical guidelines and requirements. Via within-subjects pretest-posttest experimental design, the especially adapted and developed tools were used to assess the PWUDs’ progress as they were facilitated by the said program. Results yielded significant improvements in the PWUDs’ mental wellbeing ( M  =  1.29, SD =  0.35; t(21) = 9.30, P < .00001), life satisfaction ( M  =  1.82, SD  =  0.24; t(21) = 9.89, P < .00001), and psychological functioning ( M  =  1.65, SD  =  0.19; t(21) = 8.58, P < .00001). Moreover, the PWUDs regarded the designed PPI program very highly and experienced it with positive outcomes, especially for their CSVs. Further improvement of the said program centers around proper time allotment, number of participants in the program sessions, appropriate activities per session, including specific ice breaker games, activity materials needed, and the proper sequencing of each session. These data are used to improve the PPI program structures and components. Pertinent conclusions about the gathered data were drawn, and relevant recommendations were also thereby provided.
Association of Well-Being in Middle-Aged and Older Adults With Enhanced Personal Health and Social Support: A Nationally Representative Cohort Study
Authors: Chung Ping-Chen , Chiang Yen-Sheng , Liu Yi-Chien , Chuang Yi-Fang , Hsu Hsiao-Han , Chan Ta-Chien
Published: August 2024

Objectives:

This study aimed to explore the relationship between multidimensional factors, such as environment, health status, behavior, social support, and the well-being of middle-aged and older adults.

Methods:

This study utilized data from 2 waves of the nationally representative Taiwan Longitudinal Study on Aging Survey Report (TLSA) conducted in 2015 and 2019. The TLSA assesses socioeconomic status, physical and health status, the 5-item World Health Organization Well-Being Index (WHO-5 index), and social support. Data regarding the degree of digital development were obtained from the 2020 Township Digital Development Report. We applied a generalized estimating equation (GEE) to analyze the influencing factors.

Results:

This study included 4796 participants. Residing in areas with a higher degree of digital development, having a higher socioeconomic status, and experiencing better physical and mental health were significantly associated with well-being. Furthermore, emotional and attentive support mediated the association between physical and mental status and well-being.

Conclusion:

People’s awareness of searching for and receiving social support and medical resources is important for enhancing their well-being. It is also crucial to pay attention to the living environment and maintain one’s health status to promote well-being.
Investigation of Football Fans’ Perceptions of Event Quality According to their Typologies
Authors: Halici Alperen , Azmi Yetim Ahmet
Published: August 2024

This research aims to develop a reliable and validated fan typology scale and to examine whether the perception of the quality of a sports event differs according to fan typology. In the first stage of the research, the scale was developed using quantitative research methods. Exploratory Factor Analysis (EFA) was applied to 339 fans, and Confirmatory Factor Analysis (CFA) was used on 260 fans. Analysis results show that the structure of the tested scale provides valid and reliable evidence, and the structure consists of 35 items gathered under seven dimensions. After the development of the scale, in the second stage of the research, the relationship between the typologies of the fans and the quality perceptions of the sports event was examined. While Gençlerbirliği and Ankaragücü supporters using the Eryaman Stadium constituted the universe of the research, the sample of the study consisted of 502 fans selected by criterion sampling method. A two-stage hierarchical cluster analysis was used to reveal the fan typology. In addition, the research questions were tested using the t-test, ANOVA, and χ2. It was determined that four types of fans emerged: “hooligan,”“fanatic,”“classical,” and “social.” In addition, it was determined that the perceptions of event quality differed significantly according to the fan’s typologies. In this direction, it can be said that football clubs should develop different communication strategies to improve the perception of all fan types.
Medial Meniscectomy at the Time of ACL Reconstruction Is Associated With Postoperative Anterior Tibial Translation: A Retrospective Analysis
Authors: Fithian Andrew , Manoharan Aditya , Chapek Michael , Xie Virginia , Ghahremani Jacob , Culler Mckenzie , Watarastaporn Tanya , Khan Najeeb
Published: August 2024

Background:

Medial meniscal pathology and management have not been associated with postoperative anterior tibial translation (ATT) after anterior cruciate ligament reconstruction (ACLR).

Purpose:

The purpose of this study was to evaluate the role of medial meniscal injury and treatment on pre- and postoperative ATT in the setting of primary ACLR. More specifically, the association between repairable medial meniscal tears, medial meniscectomy, and postoperative ATT, along with rates of revision surgery, was examined.

Study Design:

Cohort study; Level of evidence, 3.

Methods:

A retrospective review was performed for patients who underwent ACLR between January 1, 2010 and December 31, 2015 at a single center. Descriptive data were obtained from an institutional database for a total of 396 patients included in this study and followed for 1 year postoperatively. Statistical analysis was performed to examine associations of meniscal treatment with postoperative ATT measurements made by KT-1000 arthrometer.

Results:

A total of 243 patients underwent isolated ACLR with autograft, 72 patients underwent autograft ACLR and partial medial meniscectomy (MMx) (ACLR + MMx), and 81 patients underwent autograft ACLR and medial meniscal repair (MMR) (ACLR + MMR). Patients with ACLR + MMx had higher mean age and body mass index compared with patients in the other groups. Patients who underwent ACLR + MMx had greater postoperative side-to-side ATT compared with patients undergoing ACLR (1.55 mm vs 1.07 mm; P = .04) or patients undergoing ACLR + MMR (1.55 mm vs 1.01 mm; P = .03). The ACLR + MMx group was less likely to have symmetric (<3-mm side-to-side difference) postoperative ATT compared with the ACLR group (85% vs 93%; P = .03). There was no difference in postoperative ATT between ACLR and ACLR + MMR. Postoperative return to the operating room was greater in the ACLR + MRR group compared with the ACLR + MMx group (21.9% vs 8.2%; P = .05).

Conclusion:

MMx at the time of ACLR led to higher postoperative ATT compared with isolated ACLR or ACLR + MMR.
Paper 26: Role of Age on Survival of Anterior Cruciate Ligament Primary Repair at minimum 5-year follow-up
Authors: Rilk Sebastian , DiFelice Gregory , van der List Jelle , Vermeijden Harmen Daniel , Goodhart Gabriel , O'Brien Robert
Published: August 2024

Objectives:

Short-term follow-up of anterior cruciate ligament (ACL) primary repair (ACLPR) presented increased failure risk (37%) in patients ≤21 years of age (y/o), however low rates in patients >21 y/o (3.5%). Mid- and long-term clinical evidence for contemporary anterior cruciate ligament primary repair (ACLPR) is lacking, whereas outcomes of historical ACL repair were shown to deteriorate at midterm follow-up after initial good short-term outcomes. This study evaluates age-differentiated survival rates of ACLPR at 5-year FU to assess whether the previously presented rates at 2-year FU can be maintained at 5-year FU.

Methods:

The first 113 consecutive patients with proximal ACL tears undergoing ACLPR by a single surgeon, from 04/2008 to 09/2017, were prospectively followed up. Indication for ACLPR was determined if a proximal type I or II tear and good to excellent tissue quality was present. Failure and re-operation rates, patient reported outcome measurements (PROMs) (IKDC score, Lysholm score, Forgotten Joint score, ACL-RSI score, and Tegner Activity Scale Difference) and instrumented anterior-tibial translation side-to-side difference (ATT-SSD) were recorded at minimum 5-year FU.

Results:

A total of 96 patients (85%) with a mean final FU of 7.2 ±2.3 (5.0 – 12.8) years were evaluated. Ipsilateral reinjury rates for patients ≤21 y/o, from 2- to 5-year FU, remained stable (40.0%) with no additional failure recorded. Six additional re-injuries were detected in patients >21 y/o, leading to a failure rate of 9.8% at 5-year FU. Mean time to failure following surgery was 17 ±11 months in patients ≤21 y/o versus 26 ±16 months in patients >21 y/o. Re-operation rates for patients ≤21- and >21 y/o were 0.0% and 4.0% respectively. PROMs showed no significant differences as compared to outcomes at 2-year FU (p <.001) and 5-year ATT-SSD was 0.75 ±1.2 mm.

Conclusions:

ACLPR is correlated with a high risk of early failure (40.0% at 17 ±11 months) in patients < 21 y/o, however no additional subsequent re-injuries were reported at minimum final 5-year FU. In contrast, patients >21 y/o demonstrate low failure rates at 2- (3.5%) and 5-year FU (9.8%).
Paper 37: Outcomes of Medial Patellofemoral Ligament Reconstruction Patients Over 30 Years of Age
Authors: Magnussen Robert , Cavendish Parker , Milliron Eric , Heyniger John , Barker Tyler , Flanigan David
Published: August 2024

Objectives:

Medial patellofemoral ligament reconstruction (MPFLR) is a common procedure to treat recurrent patellofemoral instability, typically in a younger, active patient population. While many patients treated with MPFLR fall into this age group, patellar instability is encountered in older patients as well. Outcomes in older patient populations have been less frequently reported in the literature. We hypothesize that patients over 30 at the time of surgery will have poorer postoperative patient reported outcome measures (PROMs) following MPFLR than patients under age 30.

Methods:

Retrospective review was undertaken to identify patients who underwent isolated MPFLR between 2008 and 2020. Chart review was utilized to obtain patient demographic, anatomical, and surgical factors. Patients were contacted via mail and/or phone and patient-reported outcomes were recorded. PROMs included the knee injury and osteoarthritis injury outcome score (KOOS), Norwich patellar instability score, and Marx activity score. Differences between groups were evaluated by Mann-Whitney and Fisher-exact tests. KOOS and Norwich scores were also evaluated using a multivariable linear regression adjusting for the following variables selected a priori: sex, body mass index, Caton-Deschamps index, TT-TG distance, sulcus angle, and the presence or absence of ≥ Grade 2 cartilage damage.

Results:

A total of 228 patients underwent isolated MPFL reconstruction in the study period. 177 patients (78%) had data on repeat patellar dislocations at least 1 year postoperatively, with a median follow-up interval of 40.8 months (3.4 years) postoperative. Of these 177, 140 were under age 30 at time of surgery, 7 (5%) of whom had a repeat dislocation; of 37 patients at or over age 30 at time of surgery, 2 (6.6%) had a repeat dislocation. 147 patients further completed KOOS, Norwich, and Marx activity score surveys with a median follow-up of 45.3 months (3.8 years) post-operative. Patients ≥ 30 years old at surgery (n=31) had lower KOOS pain (82.1 vs 91.7; p=0.03), KOOS activities of daily living (94.1 vs 97.1; p=0.04), and Marx activity scores (1 vs 7; p<0.001) compared to the patients under age 30 (n=116) (Table 1). After adjusting for covariates, multivariable regression models for KOOS and Norwich scores showed only KOOS pain subscores were lower for patients ≥ 30 years (β= -4.2; 95% CI -8.3, -0.2; p=0.04).

Conclusions:

Patients over age 30 at the time of MPFLR demonstrated similar recurrence risk but lower KOOS pain and Marx activity scores at 3.8 years postoperative than patients under age 30 at the time of MPFLR. [Figure: see text]
Poster 130: Incidence and Treatment Characteristics of Coracoclavicular Ligament Injuries with Associated Lateral Clavicle Fractures in a Military Population
Authors: Panarello Nicholas , O'Hara Matthew , Feeley Scott , Colantonio Donald , Harrington Colin , Dickens Jonathan , Kilcoyne Kelly
Published: August 2024

Objectives:

To identify the demographics and characteristics of lateral clavicle fractures treated with coracoclavicular ligament repair or reconstruction, as well as to the subsequent postoperative complications.

Methods:

The United States Military Health System Data Repository was queried for patients with a Current Procedural Terminology (CPT) code for coracoclavicular ligament reconstruction between October 2013 and March 2020. Radiographs were evaluated for the presence of a lateral clavicle fracture at the time of initial injury and classified based on the modified Neer classification. The electronic health records to include operative reports and clinical notes were then reviewed for patient demographics, operative technique, and clinical course.

Results:

A total of 965 patients underwent coracoclavicular ligament repair or reconstruction between October 2013 and March 2020. Forty patients (4.6%) were identified with concomitant lateral clavicle fractures. The mean age of 29.575 years (SD 10.1) of which 85% male and 80% were active duty. Based on the Neer classification, there were three type I, 18 type IIB, 12 type III, and seven type V. Twenty-two of these injuries were addressed acutely (55%), while 18 were managed chronically (45%). Open reduction internal fixation of the distal clavicle was performed in 16 of the 40 patients (40%). An equivalent distribution of concomitant coracoclavicular ligament repair versus reconstruction was performed amongst the forty total patients. Postoperatively, two patients went on to nonunion and seven patients had loss of coracoclavicular reduction. Five patients returned to the operating room for removal of symptomatic hardware (3), revision (1), and irrigation and debridement (1). At the conclusion of their fracture care, five (12.5%) of patients necessitated medical separation from the military.

Conclusions:

A small subset of coracoclavicular reconstructions performed in the military occur for a concomitant lateral clavicle fracture. The majority of military patients who underwent coracoclavicular ligament repair or reconstruction in the setting of a lateral clavicle regained full, pain-free range of motion. Although malunion and nonunion are known complications of this injury pattern, only two patients went on to develop these complications. However, postoperative complications were common, occurring in 25% of patients. At the conclusion of their fracture care, five (12.5%) of patients necessitated medical separation from the military.
Poster 201: Comparison of Short-Term Patient-Reported Outcomes Between Patients Undergoing Hip Arthroscopy With Versus Without a Perineal Post
Authors: Fasulo Sydney , Marder Ryan , Kraeutler Matthew , Castrodad Iciar Davila , Mei-Dan Omer , Scillia Anthony
Published: August 2024

Objectives:

Previous studies have demonstrated rates of groin-related nerve and/or soft-tissue complications as high as 46% following hip arthroscopy; however, the recent use of a postless hip distraction setup has shown promising reductions in these complications. A recent prospective study compared postoperative complications of patients undergoing hip arthroscopy with and without the use of a perineal post, with significantly fewer complications among patients undergoing postless hip arthroscopy. The purpose of this study was to prospectively compare the short-term clinical outcomes of patients undergoing hip arthroscopy with versus without the use of a perineal post.

Methods:

A prospective, single-surgeon cohort study was performed on all patients undergoing hip arthroscopy between January 2020 and March 2022. A post-free hip distraction system was used at one center at which the senior author operates, and a setup with a perineal post was used at another surgical location. An electronic survey of patient-reported outcome measures (PROMs) was completed by each patient at a minimum of 1 year postoperatively. PROMs included a visual analog scale (VAS) for pain, University of California Los Angeles (UCLA) Activity Scale, modified Harris Hip Score (mHHS), Hip Outcome Score-Sport (HOS-Sport), and a Single Assessment Numeric Evaluation (SANE).

Results:

Sixty patients were reached for follow-up (35 post, 25 patients postless). No differences were found between the post and postless groups in terms of age at surgery (34 ± 13 vs 30 ± 11 years, p = 0.18), sex (60% vs 56% female patients, p = 0.76), body mass index (26 ± 7 vs 24 ± 4, p = 0.25), or follow-up duration (23.5 ± 8 vs 20.8 ± 10 months, p = 0.25). There was a significantly higher VAS for pain (3.0 ± 2.6 vs 1.6 ± 1.6, p = 0.03) and lower UCLA Activity Score (6.9 ± 2.5 vs 8.2 ± 2.1, p = 0.04) in the post-assisted group. There were no significant differences between groups in other PROMs including mHHS (73.4 ± 16.7 vs 81.0 ± 12.5, p = 0.07), HOS-Sport (72.4 ± 26.1 vs 82.1 ± 25.8, p = 0.18), or SANE (78.6 ± 25.2 vs 87.6 ± 12.2, p = 0.13).

Conclusions:

Postless hip arthroscopy may result in an extended reduction in pain and perhaps higher activity levels compared to traditional post-assisted hip arthroscopy. Larger studies are warranted to corroborate these findings.
Poster 360: Long-Leg Lateral Monopodal Stress Radiographs for the Assessment of Anterior Tibial Translation with Anterior Cruciate Ligament Injury: A Prospective Study
Authors: Otremba Jace , Tollefson Luke , Knowlan Claire , Kennedy Nicholas , LaPrade Robert
Published: August 2024

Objectives:

The purpose of this study is to use standing anterior cruciate ligament (ACL) stress radiographs to evaluate how posterior tibial slope (PTS) compared to anterior tibial translation (ATT) in an injured knee. A secondary purpose was to determine how posterior tibial slope (PTS) affects ATT side-to-side difference. Our hypothesis was that anterior tibial translation would be higher in the injured knee compared to the contralateral side and posterior tibial slope will have a positive effect on anterior tibial translation.

Methods:

A retrospective study of ACL stress radiographs was assessed from patients with primary ACL reconstructions with no concomitant ligamentous injury between January 2023 and August 2023. Institutional Review Board approval was obtained. The bilateral radiographs were long-leg lateral “stress views” which was accomplished by monopodal weight-bearing in 20° flexion and are a part of the initial patient workup. Stress radiographs were utilized to measure the anterior tibial translation (ATT) and posterior tibial slope (PTS) for both knees. Differences in ATT between knees and the correlation between PTS and ATT was assessed via paired t-tests and regression analysis.

Results:

A final cohort of 39 patients were analyzed using preoperative ACL stress radiographs. The results reported a significant regression with positive correlation between posterior tibial slope (PTS) and anterior tibial translation for the injured knee using both anatomic (Figure 1, P<0.001, R2=0.302) and mechanical (Figure 2, P=0.038, R2=0.111) PTS measurements. Anatomic PTS measurements are better at predicting ATT for the injured knee compared to mechanical PTS measurements.

Conclusions:

The findings of this study report a significant regression with a positive correlation between posterior tibial slope (PTS) and anterior tibial translation (ATT) of the injured knee, with anatomic PTS measurements being a better predictor of ATT than mechanical PTS measurements. This indicates an important relationship between PTS and ATT with higher PTRS predicting higher ATT.
An interdisciplinary consensus approach to pulmonary hypertension in developmental lung disease
Authors: Varghese Nidhy P. , Austin Eric D. , Galambos Csaba , Mullen Mary P. , Yung Delphine , Guillerman R. Paul , Vargas Sara O. , Avitabile Catherine M. , Chartan Corey A. , Cortes-Santiago Nahir , Ibach Michaela , Jackson Emma O. , Jarrell Jill Ann , Keller Roberta L. , Krishnan Usha S. , Patel Kalyani R. , Pogoriler Jennifer , Whalen Elise C. , Wikenheiser-Brokamp Kathryn A. , Villafranco Natalie M. , Hopper Rachel K. , Usha Raj J. , Abman Steven H.
Published: August 2024

It is increasingly recognised that diverse genetic respiratory disorders present as severe pulmonary hypertension (PH) in the neonate and young infant, but many controversies and uncertainties persist regarding optimal strategies for diagnosis and management to maximise long-term outcomes. To better define the nature of PH in the setting of developmental lung disease (DEVLD), in addition to the common diagnoses of bronchopulmonary dysplasia and congenital diaphragmatic hernia, we established a multidisciplinary group of expert clinicians from stakeholder paediatric specialties to highlight current challenges and recommendations for clinical approaches, as well as counselling and support of families. In this review, we characterise clinical features of infants with DEVLD/DEVLD-PH and identify decision-making challenges including genetic evaluations, the role of lung biopsies, the use of imaging modalities and treatment approaches. The importance of working with team members from multiple disciplines, enhancing communication and providing sufficient counselling services for families is emphasised to create an interdisciplinary consensus.
Transcriptomic profiling reveals histone acetylation-regulated genes involved in somatic embryogenesis in Arabidopsis thaliana
Authors: Wójcikowska Barbara , Chwiałkowska Karolina , Nowak Katarzyna , Citerne Sylvie , Morończyk Joanna , Wójcik Anna Maria , Kiwior-Wesołowska Agnieszka , Francikowski Jacek , Kwaśniewski Mirosław , Gaj Małgorzata Danuta
Published: August 2024

Background

Somatic embryogenesis (SE) exemplifies the unique developmental plasticity of plant cells. The regulatory processes, including epigenetic modifications controlling embryogenic reprogramming of cell transcriptome, have just started to be revealed.

Results

To identify the genes of histone acetylation-regulated expression in SE, we analyzed global transcriptomes of Arabidopsis explants undergoing embryogenic induction in response to treatment with histone deacetylase inhibitor, trichostatin A (TSA). The TSA-induced and auxin (2,4-dichlorophenoxyacetic acid; 2,4-D)-induced transcriptomes were compared. RNA-seq results revealed the similarities of the TSA- and auxin-induced transcriptomic responses that involve extensive deregulation, mostly repression, of the majority of genes. Within the differentially expressed genes (DEGs), we identified the master regulators (transcription factors - TFs) of SE, genes involved in biosynthesis, signaling, and polar transport of auxin and NITRILASE-encoding genes of the function in indole-3-acetic acid (IAA) biosynthesis. TSA-upregulated TF genes of essential functions in auxin-induced SE, included LEC1/LEC2, FUS3, AGL15, MYB118, PHB, PHV, PLTs, and WUS/WOXs. The TSA-induced transcriptome revealed also extensive upregulation of stress-related genes, including those related to stress hormone biosynthesis. In line with transcriptomic data, TSA-induced explants accumulated salicylic acid (SA) and abscisic acid (ABA), suggesting the role of histone acetylation (Hac) in regulating stress hormone-related responses during SE induction. Since mostly the adaxial side of cotyledon explant contributes to SE induction, we also identified organ polarity-related genes responding to TSA treatment, including AIL7/PLT7, RGE1, LBD18, 40, HB32, CBF1, and ULT2. Analysis of the relevant mutants supported the role of polarity-related genes in SE induction.

Conclusion

The study results provide a step forward in deciphering the epigenetic network controlling embryogenic transition in somatic cells of plants.
Precise partial root-zone irrigation technique and potassium-zinc fertigation management improve maize physio-biochemical responses, yield, and water use in arid climate
Authors: Elshamly Ayman M. S. , Abaza A. S.
Published: August 2024

Background

To optimize irrigation water use and productivity, understanding the interactions between plants, irrigation techniques, and fertilization practices is crucial. Therefore, the experiment aims to assess the effectiveness of two application methods of potassium humate combined with chelated zinc under partial root-zone drip irrigation techniques on maize nutrient uptake, yield, and irrigation water use efficiency across two irrigation levels.

Methods

Open-field experiments were carried out in two summer seasons of 2021 and 2022 under alternate and fixed partial root-zone drip irrigation techniques to investigate their impacts at two irrigation levels and applied foliar and soil applications of potassium humate or chelated zinc in a sole and combinations on maize.

Results

Deficit irrigation significantly increased hydrogen peroxide levels and decreased proline, antioxidant enzymes, carbohydrate, chlorophyll (a + b), and nutrient uptake in both partial root-zone techniques. The implementation of combined soil application of potassium humate and chelated zinc under drought conditions on maize led to varying impacts on antioxidant enzymes and nutritional status, depending on the type of partial root-zone technique. Meanwhile, the results showed that fixed partial root-zone irrigation diminished the negative effects of drought stress by enhancing phosphorus uptake (53.8%), potassium uptake (59.2%), proline (74.4%) and catalase (75%); compared to the control. These enhancements may contribute to improving the defense system of maize plants in such conditions. On the other hand, the same previous treatments under alternate partial root zone modified the defense mechanism of plants and improved the contents of peroxidase, superoxide dismutase, and the uptake of magnesium, zinc, and iron by 81.3%, 82.3%, 85.1%, 56.9%, and 80.2%, respectively.

Conclusions

Adopting 75% of the irrigation requirements and treating maize plants with the soil application of 3 g l−1 potassium humate combined with 1.25 kg ha−1 chelated zinc under alternate partial root-zone technique, resulted in the maximum root length, leaf water content, chlorophyll content, yield, and irrigation water use efficiency.
Decoding IBS: a machine learning approach to psychological distress and gut-brain interaction
Authors: Lundervold Astri J. , Billing Julie E. , Berentsen Birgitte , Lied Gülen A. , Steinsvik Elisabeth K. , Hausken Trygve , Lundervold Arvid
Published: August 2024

Purpose

Irritable bowel syndrome (IBS) is a diagnosis defined by gastrointestinal (GI) symptoms like abdominal pain and changes associated with defecation. The condition is classified as a disorder of the gut-brain interaction (DGBI), and patients with IBS commonly experience psychological distress. The present study focuses on this distress, defined from reports of fatigue, anxiety, depression, sleep disturbances, and performance on cognitive tests. The aim was to investigate the joint contribution of these features of psychological distress in predicting IBS versus healthy controls (HCs) and to disentangle clinically meaningful subgroups of IBS patients.

Methods

IBS patients ($$n = 49$$

n
=
49

) and HCs ($$n = 28$$

n
=
28

) completed the Chalder Fatigue Scale (CFQ), the Hamilton Anxiety and Depression Scale (HADS), and the Bergen Insomnia Scale (BIS), and performed tests of memory function and attention from the Repeatable Battery Assessing Neuropsychological Symptoms (RBANS). An initial exploratory data analysis was followed by supervised () and unsupervised () classification procedures.

Results

The explorative data analysis showed that the group of IBS patients obtained significantly more severe scores than HCs on all included measures, with the strongest pairwise correlation between fatigue and a quality measure of sleep disturbances. The supervised classification model correctly predicted belongings to the IBS group in 80% of the cases in a test set of unseen data. Two methods for calculating feature importance in the test set gave mental and physical fatigue and anxiety the strongest weights. An unsupervised procedure with $$K = 3$$

K
=
3

showed that one cluster contained 24% of the patients and all but two HCs. In the two other clusters, their IBS members were overall more impaired, with the following differences. One of the two clusters showed more severe cognitive problems and anxiety symptoms than the other, which experienced more severe problems related to the quality of sleep and fatigue. The three clusters were not different on a severity measure of IBS and age.

Conclusion

The results showed that psychological distress is an integral component of IBS symptomatology. The study should inspire future longitudinal studies to further dissect clinical patterns of IBS to improve the assessment and personalized treatment for this and other patient groups defined as disorders of the gut-brain interaction. The project is registered at https://classic.clinicaltrials.gov/ct2/show/NCT04296552 20/05/2019.
Pakistan’s path to universal health coverage: national and regional insights
Authors: Yang Di , Nikoloski Zlatko , Khalid Ghazna , Mossialos Elias
Published: August 2024

Background

Universal Health Coverage (UHC) is a common health policy objective outlined in the Sustainable Development Goals. With provincial governments taking the initiative, Pakistan has implemented and extended UHC program amid a complex public health landscape. In this context, we assess Pakistan’s progress toward achieving UHC at the national and subnational level.

Methods

We use data from the Demographic and Health Surveys and the Household Integrated Economic Survey to construct a UHC index at the national and subnational level for 2007, 2013, and 2018. Furthermore, we use Concentration Index (CI) and CI decomposition methodologies to assess the primary drivers of inequality in accessing medical services. Logistic regression and Sartori’s two-step model are applied to examine the key determinants of catastrophic health expenditure (CHE).

Results

Our analysis underscores Pakistan’s steady progress toward UHC, while revealing significant provincial disparities in UHC progress. Provinces with lower poverty rate achieve higher UHC index, which highlights the synergy of poverty alleviation and UHC expansion. Among the examined indicators, child immunization remains a key weakness that one third of the children are not fully vaccinated and one sixth of these not-fully-vaccinated children have never received any vaccination. Socioeconomic status emerges as a main contributor to disparities in accessing medical services, albeit with a declining trend over time. Household socioeconomic status is negatively correlated with CHE incidence, indicating that wealthier households are less susceptible to CHE. For individuals experiencing CHE, medicine expenditure takes the highest share of their health spending, registering a staggering 70% in 2018.

Conclusion

Pakistan’s progress toward UHC aligns closely with its economic development trajectory and policy efforts in expanding UHC program. However, economic underdevelopment and provincial disparities persist as significant hurdles on Pakistan’s journey toward UHC. We suggest continued efforts in UHC program expansion with a focus on policy consistency and fiscal support, combined with targeted interventions to alleviate poverty in the underdeveloped provinces.
Clinical and genetic characteristics of Chinese patients with congenital fibrosis of the extraocular muscles
Authors: Wu Jin , Huang Lijuan , Zhou Yunyu , Xie Yan , Mo Tong , Li Ningdong
Published: August 2024

Objective

This study aimed to describe the clinical and genetic characteristics of Chinese patients with congenital fibrosis of the extraocular muscles (CFEOM), and to evaluate the phenotype–genotype correlations in these patients.

Methods

This was a retrospective study. Patients with CFEOM underwent detailed ophthalmic examinations and magnetic resonance imaging (MRI). Panel-based next-generation sequencing was performed to identify pathogenic variants of disease-causing genes.

Results

Sixty-two patients with CFEOM were recruited into this study. Thirty-nine patients were diagnosed with CFEOM1 and 23 with CFEOM3. Forty-nine of the 62 patients with CFEOM carried either KIF21A (41/49) or TUBB3 variants (8/49). Six known missense variants in the KIF21A and TUBB3 genes, and a novel variant (c.3906T > A, p.D1302E) in the KIF21A gene were detected. Most patients with CFEOM1 carrying the KIF21A mutation displayed isolated CFEOM, whereas patients with CFEOM3 carrying the TUBB3 mutation had a wide range of clinical manifestations, either CFEOM alone or syndromes. Nystagmus was also present in 12 patients with CFEOM. Furthermore, the MRI findings varied, ranging from attenuation of the extraocular muscles to dysgenesis of the cranial nerves and brain structure.

Conclusions

The novel variants identified in this study will further expand the spectrum of pathogenic variants in CFEOM-related genes. However, no phenotype–genotype correlations were established because of the diversity of the clinical characteristics of these patients.
Guide to extraluminal fish bone retrieval with serial computed tomography scans: a case series
Authors: Yew Ting Ting , Tang Ing Ping , Lim Li Yun , Cheah Yuanzhi , Yew Shiong Leong
Published: August 2024

Background

Fish bone ingestion is commonly encountered in emergency department. It poses a diagnostic and therapeutic challenge particularly when it migrates extraluminally, necessitating a comprehensive and multidisciplinary approach for successful management.

Case presentation

Here we reported four cases of extraluminal fish bone. The first patient was a 68-year-old Chinese man who had odynophagia shortly after a meal involving fish. The second was a 50-year-old Iban man who reported a sharp throat pain after consuming fish 1 day prior. The third patient was a 55-year-old Malay woman who developed throat pain and odynophagia after consuming fish 1 day earlier. The fourth patient, a 70 year-old Iban man, presented late with odynophagia, neck pain, swelling, and fever 1 week after fish bone ingestion. These unintentional fish bone ingestions faced challenges and required repeat computed tomography scans using multiplanar reconstruction in guiding the surgical removal of the fish bone.

Conclusion

We underscore the significance of multiplanar reconstruction in pinpointing the fish bone’s location, demonstrating the migratory route, and devising an accurate surgical plan.