bluuebunny/crossref_metadata_2025 huggingface dataset:
The in vitro effects of black soldier fly larvae (Hermitia illucens) oil as a high-functional active ingredient for inhibiting hyaluronidase, anti-oxidation benefits, whitening, and UVB protection
Authors: Phongpradist Rungsinee , Semmarath Warathit , Kiattisin Kanokwan , Jiaranaikulwanitch Jutamas , Chaiyana Wantida , Chaichit Siripat , Phimolsiripol Yuthana , Dejkriengkraikul Pornngarm , Ampasavate Chadarat
Published: September 2023

Objective: Larvae of Hermitia illucens, or black soldier fly larvae (BSFL), have been recognized for their high lipid yield with a remarkable fatty acid profile. BSFL oil (SFO) offers the added value of a low environmental footprint and a sustainable product. In this study, the characteristics and cosmetic-related activities of SFO were investigated and compared with rice bran oil, olive oil and krill oil which are commonly used in cosmetics and supplements.

Methods: The physicochemical characteristics were determined including acid value, saponification value, unsaponifiable matter and water content of SFO. The fatty acid composition was determined using GC-MS equipped with TR-FAME. The in vitro antioxidant properties were determined using DPPH, FRAP and lipid peroxidation inhibition assays. Antihyaluronidase (anti-HAase) activity was measured by detecting enzyme activity and molecular docking of candidate compounds toward the HAase enzyme. The safety assessment towards normal human cells was determined using the MTT assay and the UVB protection upon UVB-irradiated fibroblasts was determined using the DCF-DA assay. The whitening effect of SFO was determined using melanin content inhibition.

Results: SFO contains more than 60% polyunsaturated fatty acids followed by saturated fatty acids (up to 37%). The most abundant component found in SFO was linoleic acid (C18:2 n-6 cis). Multiple anti-oxidant mechanisms of SFO were discovered. In addition, SFO and krill oil prevented hyaluronic acid (HA) degradation via strong HAase inhibition comparable with the positive control, oleanolic acid. The molecular docking confirmed the binding interactions and molecular recognition of major free fatty acids toward HAase. Furthermore, SFO exhibited no cytotoxicity on primary human skin fibroblasts, HaCaT keratinocytes and PBMCs (IC50 values > 200 μg/mL). SFO possessed significant in-situ anti-oxidant activity in UVB-irradiated fibroblasts and the melanin inhibition activity as effective as well-known anti-pigmenting compounds (kojic acid and arbutin, p < 0.05).

Conclusion: This study provides scientific support for various aspects of SFO. SFO can be considered an alternative oil ingredient in cosmetic products with potential implications for anti-skin aging, whitening and UVB protection properties, making it a potential candidate oil in the cosmetic industry.
Dapagliflozin promotes angiogenesis in hindlimb ischemia mice by inducing M2 macrophage polarization
Authors: Yang Heng , Lan Wanqi , Liu Wu , Chen Tingtao , Tang Yanhua
Published: September 2023

Critical limb ischemia (CLI) is associated with a higher risk of limb amputation and cardiovascular death. Dapagliflozin has shown great potential in the treatment of cardiovascular disease. However, the effects of dapagliflozin on CLI and the underlying mechanisms have not been fully elucidated. We evaluated the effect of dapagliflozin on recovery from limb ischemia using a mouse model of hindlimb ischemia. The flow of perfusion was evaluated using a laser Doppler system. Tissue response was assessed by analyzing capillary density, arterial density, and the degree of fibrosis in the gastrocnemius muscle. Immunofluorescence and Western blot were used to detect the expression of macrophage polarization markers and inflammatory factors. Our findings demonstrate the significant impact of dapagliflozin on the acceleration of blood flow recovery in a hindlimb ischemia mouse model, concomitant with a notable reduction in limb necrosis. Histological analysis revealed that dapagliflozin administration augmented the expression of key angiogenic markers, specifically CD31 and α-SMA, while concurrently mitigating muscle fibrosis. Furthermore, our investigation unveiled dapagliflozin’s ability to induce a phenotypic shift of macrophages from M1 to M2, thereby diminishing the expression of inflammatory factors, including IL-1β, IL-6, and TNF-α. These effects were partially mediated through modulation of the NF-κB signaling pathway. Lastly, we observed that endothelial cell proliferation, migration, and tube-forming function are enhanced in vitro by utilizing a macrophage-conditioned medium derived from dapagliflozin treatment. Taken together, our study provides evidence that dapagliflozin holds potential as an efficacious therapeutic intervention in managing CLI by stimulating angiogenesis, thereby offering a novel option for clinical CLI treatment.
Utility of pharmacogenetic testing to optimise antidepressant pharmacotherapy in youth: a narrative literature review
Authors: Roberts Bradley , Cooper Zahra , Lu Stephanie , Stanley Susanne , Majda Bernadette T. , Collins Khan R. L. , Gilkes Lucy , Rodger Jennifer , Akkari P. Anthony , Hood Sean D.
Published: September 2023

Pharmacogenetics (PGx) is the study and application of how interindividual differences in our genomes can influence drug responses. By evaluating individuals’ genetic variability in genes related to drug metabolism, PGx testing has the capabilities to individualise primary care and build a safer drug prescription model than the current “one-size-fits-all” approach. In particular, the use of PGx testing in psychiatry has shown promising evidence in improving drug efficacy as well as reducing toxicity and adverse drug reactions. Despite randomised controlled trials demonstrating an evidence base for its use, there are still numerous barriers impeding its implementation. This review paper will discuss the management of mental health conditions with PGx-guided treatment with a strong focus on youth mental illness. PGx testing in clinical practice, the concerns for its implementation in youth psychiatry, and some of the barriers inhibiting its integration in clinical healthcare will also be discussed. Overall, this paper provides a comprehensive review of the current state of knowledge and application for PGx in psychiatry and summarises the capabilities of genetic information to personalising medicine for the treatment of mental ill-health in youth.
The effects of a firefighting simulation on the vascular and autonomic functions and cognitive performance: a randomized crossover study
Authors: Teixeira Iara G. , Verzola Marcio R. , Filipini Richard E. , Speretta Guilherme F.
Published: September 2023

Introduction: During firefighting, physical and cognitive demands increase. However, the stress inherent to these events can decrease cognitive performance and increase the risk of cardiovascular events in firefighters. Thus, this crossover study aimed to evaluate the effects of a firefighting Simulation on cognitive performance and vascular and autonomic functions in military firefighters.

Methods: Sixteen firefighters (37.8 ± 5.6 years) underwent anthropometry, mental health status, and sleep quality assessments. They randomly performed two interventions, Simulation (Firefighting tasks; 10.0 ± 1.1 min) and Control (rest for 10 min), on different days. After both interventions, cognitive performance was assessed using the Stroop Test, Paced Auditory Serial Addition Test, and Trail Making Test. Then, the vascular function was assessed using ultrasonography through the carotid artery reactivity to the cold pressor test. The arterial pressure, heart rate, and cardiac intervals were recorded before interventions. The cardiac intervals were also measured during the cold pressor test. Student’s t-test and Wilcoxon were used for comparisons between Control and Simulation and the analysis of variance for repeated measures was used for comparison over time during the cold pressor test. A significance level of p < 0.05 was adopted.

Results: Although the mean and maximum heart rate were higher before the Simulation (p < 0.0001), all the heart rate variability parameters (p > 0.05) and mean arterial pressure (p > 0.3795) were similar before the interventions. After Simulation, the cognitive performance was similar to Control (p > 0.05), except for the improvement in Stroop Test part B (p < 0.0001). After Simulation, carotid artery reactivity was attenuated (p < 0.0010). During the cold pressor test, the high-frequency band of the heart rate variability was lower after the Simulation (p < 0.0104).

Discussion: Although firefighting Simulation did not substantially change cognitive performance, the lower carotid artery reactivity and parasympathetic modulation to the heart during the cold pressor test may contribute to greater vulnerability to cardiovascular events in firefighters on duty.
Mechanistic understanding of perianth traits hindering pollination in Aristolochia contorta Bunge
Authors: Park Si-Hyun , Kim Jae Geun
Published: September 2023

Insects are vital pollinators for angiosperms, playing a crucial role in their reproductive success and fruit production. Aristolochia contorta is a perennial herbaceous vine that occurs in fragmented populations across East Asia. One notable feature of this plant is its trap flower, which employs a unique mechanism to attract, trap, retain, and release insects, ensuring effective pollination. The presence of this trap flower significantly influences the pollination system of A. contorta. Field surveys and pollination experiments were conducted to understand the processes and effectiveness of its pollination mechanism. It was allogamous and was pollinated by the species from Ceratopogonidae. During the insect attraction stage, 11.57% of the flowers contained insects, primarily Ceratopogonidae spp. Most Ceratopogonidae spp. concentrated in few flowers, indicating that although overall attraction might be modest, specific flowers acted as significant focal points for gathering. Trichomes effectively trapped Ceratopogonidae spp. inside flower tubes. In the retention stage, 26.16% of Ceratopogonidae spp. were loaded with pollen grains, but only 7.91% of those exited the flowers in the release stage. The sticky texture of the perianth’s internal cavity posed challenges during this release, leading to adhesion and clogging of the narrow perianth tube. Consequently, a significant portion of Ceratopogonidae spp. became trapped on the perianth wall and perished. This highlights that despite the significant energy and resources invested in flower development, the perianth contributes to the low pollination effectiveness. This study revealed additive factors with negative effects on pollination, including the densely clustered distribution of its pollinators within only a few flowers, insufficient pollen loading onto pollinators, hindered release of entrapped pollinators due to the perianth adhesive surface, and a high rate of defective pollen grains in A. contorta. These factors account for the observed phenomenon of low fruit set (7.7%) and contribute to the diminished rate of sexual reproduction in A. contorta populations. This might lead the species to heavily rely on asexual reproduction, which could potentially lead to gene erosion within populations. The implications of these findings extend to the ecological and conservation aspects, emphasizing the need to understand and conserve the unique pollination system of A. contorta.
Effects of biochar application and nutrient fluctuation on the growth, and cadmium and nutrient uptake of Trifolium repens with different planting densities in Cd-contaminated soils
Authors: Zheng Wei-Long , Wang Yan-Fei , Mo Jingya , Zeng Pu , Chen Jiayi , Sun Chenliang
Published: September 2023

Biochar has been used to remediate contaminated-soil with heavy metals, however, less is known on how biochar interacts with planting density and nutrient fluctuation to affect the remediation. A pot experiment was conducted in the greenhouse to investigate the effects of biochar application (without vs. with 1% biochar, g/g substrate), nutrient fluctuation (constant vs. pulsed) and planting density (1-, 3- and 6-individuals per pot) on the growth, and cadmium (Cd) and nutrient uptake of Trifolium repens population. Our results found that the growth of T. repens population increased significantly with increasing planting density, and the increment decreased with increasing planting density. Both the Cd and nutrient uptake were higher at higher planting density (e.g., 3- and 6-individuals) than at lower planting density (e.g., 1-individual). Biochar application increased the biomass and shoot Cd uptake, but decreased the ratio of root to shoot and root Cd uptake of T. repens population, the effects of which were significantly influenced by planting density. Although nutrient fluctuation had no effect on the growth of T. repens population, but its interaction with planting density had significant effects on Cd uptake in tissues. Overall, the effects of biochar application and nutrient fluctuation on the growth and Cd uptake were both influenced by planting density in the present study. Our findings highlight that biochar application and constant nutrient supply at an appropriate planting density, such as planting density of 3-individuals per pot in the present study, could promote the growth, and Cd and nutrient uptake of T. repens population.
Patterns of deep fine root and water utilization amongst trees, shrubs and herbs in subtropical pine plantations with seasonal droughts
Authors: Jiang Peipei , Yan Jinliang , Liu Rongxin , Zhang Xuejie , Fan Shoujin
Published: September 2023

Introduction

Seasonal droughts will become more severe and frequent under the context of global climate change, this would result in significant variations in the root distribution and water utilization patterns of plants. However, research on the determining factors of deep fine root and water utilization is limited.

Methods

We measured the fine root biomass and water utilization of trees, shrubs and herbs, and soil properties, light transmission, and community structure parameters in subtropical pine plantations with seasonal droughts.

Results and Discussion

We found that the proportion of deep fine roots (below 1 m depth) is only 0.2-5.1%, but that of deep soil water utilization can reach 20.9-38.6% during the dry season. Trees improve deep soil water capture capacity by enhancing their dominance in occupying deep soil volume, and enhance their deep resource foraging by increasing their branching capacity of absorptive roots. Shrubs and herbs showed different strategies for deep water competition: shrubs tend to exhibit a “conservative” strategy and tend to increase individual competitiveness, while herbs exhibited an “opportunistic” strategy and tend to increase variety and quantity to adapt to competitions.

Conclusion

Our results improve our understanding of different deep fine root distribution and water use strategies between overstory trees and understory vegetations, and emphasize the importance of deep fine root in drought resistance as well as the roles of deep soil water utilization in shaping community assembly.
Yoga and music intervention reduces inattention, hyperactivity/impulsivity, and oppositional defiant disorder in children’s consumer with comorbid ADHD and ODD
Authors: Luo Xue , Huang Xu , Lin Shuang
Published: September 2023

Introduction

To analyze the impact of yoga and music intervention on child consumers, we selected 60 eligible child consumers from yoga and music companies.

Methods

This preliminary study used a randomized controlled design to investigate whether a 16-week combined yoga and music intervention improves attention, hyperactivity/impulsivity, and oppositional defiant disorder (ODD) in 60 children with attention-deficit/hyperactivity disorder (ADHD) comorbid with ODD aged 4–6 years. It also preliminarily identified which intervention is best for these children among three types: combined yoga and music, yoga-only, and musiconly interventions. We used both the parent- and teacher-rated MTA SNAP-IV ADHD Rating Scale for data collection.

Results

We found that the combined yoga and music intervention had a positive effect on inattention, hyperactivity/impulsivity, and ODD in children with comorbid ADHD and ODD. The combined yoga and music intervention was the most effective in reducing inattention (in repeated measures ANOVA effect size, 0.9; followed by the yoga- and the music-only interventions, respectively), hyperactivity/impulsivity (effect size, 0.92), and ODD behaviors (effect size, 0.93) in children with comorbid ADHD and ODD. Thus, the combined yoga and music intervention was the most effective and had a more comprehensive effect on children with combined ADHD and ODD compared with the two other interventions (i.e., yoga- and music-only interventions).

Discussion

Our findings provide preliminary evidence for the use of combined yoga and music interventions on a daily basis as a safe and effective adjunctive treatment for children with comorbid ADHD and ODD. The children in the article refer to child consumers of yoga and music companies.
Detection of emotion by text analysis using machine learning
Authors: Machová Kristína , Szabóova Martina , Paralič Ján , Mičko Ján
Published: September 2023

Emotions are an integral part of human life. We know many different definitions of emotions. They are most often defined as a complex pattern of reactions, and they could be confused with feelings or moods. They are the way in which individuals cope with matters or situations that they find personally significant. Emotion can also be characterized as a conscious mental reaction (such as anger or fear) subjectively experienced as a strong feeling, usually directed at a specific object. Emotions can be communicated in different ways. Understanding the emotions conveyed in a text or speech of a human by a machine is one of the challenges in the field of human-machine interaction. The article proposes the artificial intelligence approach to automatically detect human emotions, enabling a machine (i.e., a chatbot) to accurately assess emotional state of a human and to adapt its communication accordingly. A complete automation of this process is still a problem. This gap can be filled with machine learning approaches based on automatic learning from experiences represented by the text data from conversations. We conducted experiments with a lexicon-based approach and classic methods of machine learning, appropriate for text processing, such as Naïve Bayes (NB), support vector machine (SVM) and with deep learning using neural networks (NN) to develop a model for detecting emotions in a text. We have compared these models’ effectiveness. The NN detection model performed particularly well in a multi-classification task involving six emotions from the text data. It achieved an F1-score = 0.95 for sadness, among other high scores for other emotions. We also verified the best model in use through a web application and in a Chatbot communication with a human. We created a web application based on our detection model that can analyze a text input by web user and detect emotions expressed in a text of a post or a comment. The model for emotions detection was used also to improve the communication of the Chatbot with a human since the Chatbot has the information about emotional state of a human during communication. Our research demonstrates the potential of machine learning approaches to detect emotions from a text and improve human-machine interaction. However, it is important to note that full automation of an emotion detection is still an open research question, and further work is needed to improve the accuracy and robustness of this system. The paper also offers the description of new aspects of automated detection of emotions from philosophy-psychological point of view.
Relationships between the magnitude of representational momentum and the spatial and temporal anticipatory judgments of opponent’s kicks in taekwondo
Authors: Imanaka Kuniyasu , Sugi Takahiro , Nakamoto Hiroki
Published: September 2023

For successful actions in a fast, dynamic environment such as sports, a quick successful anticipation of a forthcoming environmental state is essential. However, the perceptual mechanisms involved in successful anticipation are not fully understood. This study examined the relationships between the magnitude of representational momentum (RM) as a forward displacement of the memory representation of the final position of a moving object (which implies that observers perceptually “see” a near future forthcoming dynamic environmental state) and the temporal and spatial anticipatory judgments of the opponent’s high or middle kicks in taekwondo. Twenty-seven participants (university taekwondo club members and non-members) observed video clips of taekwondo kicks that vanished at one of 10 frame positions prior to the kick impact and performed three tasks consecutively: anticipatory coincidence timing (CT) with the arrival of kick impact, judgment of the kick type (high and middle kicks) by forced choice, and judgment of the vanishing frame position (measuring RM). Our results showed significant group effects for the number of correct kick-type judgments and the judgment threshold for kick-type choice (kick-typeJT), which was estimated in terms of individual psychometric function curves. A significant correlation was found between the magnitude of RM (estimated at kick-typeJT) and kick-typeJT, but not between the CT errors (estimated at kick-typeJT) and kick-typeJT. This indicates that the magnitude of RM may play an influential role in quick kick-type judgments, but not in coincidence timing while observing an opponent’s kick motion. These findings suggest that subjective anticipatory perception or judgment of the future spatial state is vital to anticipatory actions under severe time constraints.
Effect of an activity wristband-based intermittent teaching unit in Physical Education on studentsʼ physical activity and its psychological mediators: a cluster-randomized controlled trial. School-fit study
Authors: Guijarro-Romero Santiago , Mayorga-Vega Daniel , Casado-Robles Carolina , Viciana Jesús
Published: September 2023

Objective

The main objective of the present study was to examine the effects of an intermittent teaching unit based on the use of activity wristbands and behavior modification strategies on high school studentsʼ perceptions of autonomy support, satisfaction of basic psychological needs, motivation toward Physical Education and physical activity, intention to be physically active, and habitual physical activity levels.

Materials and methods

An initial sample of 353 high school students (final sample = 175; 45.7% females; mean age = 13.3 ± 1.2 years) from two public high schools were cluster-randomly assigned into the intermittent (IG, n = 100) and control (CG, n = 75) groups. The IG performed an intermittent teaching unit twice a week for eight weeks. Specifically, the last 15 min of each lesson were used. As the main strategy to promote the practice of regular physical activity, students wore an activity wristband the whole day during the intervention period. Additionally, other behavior modification strategies were also applied (e.g., educational counseling, physical activity goals or reminders). Regarding the CG, during the intervention period (i.e,, the eight weeks that took place the intermittent teaching unit) they also performed two Physical Education sessions, but without using activity wristbands or other behavior modification strategies. Before and after the intervention, as well as at the end of the follow-up period (six weeks), students’ physical activity practice mediators and physical activity levels were measured by validated questionnaires.

Results

The Multilevel Linear Model results showed that the IG students statistically significantly improved cognitive and procedural autonomy support from pre- to post-intervention (p < 0.05). They also statistically significantly improved autonomy and relatedness basic psychological needs, and autonomous motivation toward physical activity scores from post-intervention to follow-up (p < 0.05). Moreover, the results showed that the IG students statistically significantly improved habitual physical activity scores from pre- to post-intervention, and from post-intervention to follow-up (p < 0.05).

Conclusion

The intermittent teaching unit based on the use of activity wristbands and other behavior modification strategies was effective for improving studentsʼ autonomy support and habitual physical activity levels, but not the rest of physical activity practice mediators.

Clinical trial registration

https://register.clinicaltrials.gov/, ID: NCT05949463.
Anxiety in response to the climate and environmental crises: validation of the Hogg Eco-Anxiety Scale in Germany
Authors: Heinzel Stephan , Tschorn Mira , Schulte-Hutner Michael , Schäfer Fabian , Reese Gerhard , Pohle Carina , Peter Felix , Neuber Michael , Liu Shuyan , Keller Jan , Eichinger Michael , Bechtoldt Myriam
Published: September 2023

Background

As the climate and environmental crises unfold, eco-anxiety, defined as anxiety about the crises’ devastating consequences for life on earth, affects mental health worldwide. Despite its importance, research on eco-anxiety is currently limited by a lack of validated assessment instruments available in different languages. Recently, Hogg and colleagues proposed a multidimensional approach to assess eco-anxiety. Here, we aim to translate the original English Hogg Eco-Anxiety Scale (HEAS) into German and to assess its reliability and validity in a German sample.

Methods

Following the TRAPD (translation, review, adjudication, pre-test, documentation) approach, we translated the original English scale into German. In total, 486 participants completed the German HEAS. We used Bayesian confirmatory factor analysis (CFA) to assess whether the four-factorial model of the original English version could be replicated in the German sample. Furthermore, associations with a variety of emotional reactions towards the climate crisis, general depression, anxiety, and stress were investigated.

Results

The German HEAS was internally consistent (Cronbach’s alphas 0.71–0.86) and the Bayesian CFA showed that model fit was best for the four-factorial model, comparable to the factorial structure of the original English scale (affective symptoms, rumination, behavioral symptoms, anxiety about personal impact). Weak to moderate associations were found with negative emotional reactions towards the climate crisis and with general depression, anxiety, and stress.

Discussion

Our results support the original four-factorial model of the scale and indicate that the German HEAS is a reliable and valid scale to assess eco-anxiety in German speaking populations.
Phenomenology yesterday, today, and tomorrow: a proposed phenomenological response to the double challenges of contemporary recovery-oriented person-centered mental health care
Authors: Messas Guilherme , Stanghellini Giovanni , Fulford K. W. M. (Bill)
Published: September 2023

This paper argues that a dialectical synthesis of phenomenology’s traditional twin roles in psychiatry (one science-centered, the other individual-centered) is needed to support the recovery-oriented practice that is at the heart of contemporary person-centered mental health care. The paper is in two main sections. Section I illustrates the different ways in which phenomenology’s two roles have played out over three significant periods of the history of phenomenology in 20th century psychiatry: with the introduction of phenomenology in Karl Jaspers’ General Psychopathology in 1913; with the development a few years later of structural phenomenological psychopathology; and in the period of post-War humanism. Section II is concerned with the role of phenomenology in contemporary mental health. There has been a turn to phenomenology in the current period, we argue, in response to what amounts to an uncoupling of academic psychiatry from front-line clinical care. Corresponding with the two roles of phenomenology, this uncoupling has both scientific aspects and clinical aspects. The latter, we suggest, is most fully expressed in a new model of “recovery,” defined, not by the values of professionals as experts-by-training, but by the values of patients and carers as experts-by-experience, specifically, by what is important to the quality of life of the individual concerned in the situation in question. We illustrate the importance of recovery, so defined, and the challenges raised by it for both the evidence-base and the values-base of clinical decision-making, with brief clinical vignettes. It is to these challenges we argue, that phenomenology through a synthesis of its twin roles is uniquely equipped to respond. Noting, however, the many barriers to such a synthesis, we argue that in the current state of development of the field, it is by way of a dialectical synthesis of phenomenology’s roles that we should proceed. From such a dialectic, a genuine synthesis of roles may ultimately emerge. We conclude with a note on the wider significance of these developments, arguing that contrary to 20th century stereotypes, they show psychiatry to be leading the way for healthcare as a whole, in developing the resources for 21st century person-centered clinical care.
Cultural variations in perceptions and reactions to social norm transgressions: a comparative study
Authors: Chen-Xia Xing J. , Betancor Verónica , Rodríguez-Gómez Laura , Rodríguez-Pérez Armando
Published: September 2023

Introduction

Humans are similar but behave differently, and one main reason is the culture in which they are born and raised. The purpose of this research is to examine how the perception and reaction to those who transgress social norms may vary based on the individualism/collectivism of their culture.

Methods

A study (N = 398) conducted in the United Kingdom, Spain, and China showed differences in the perception and reaction to incivilities based on individualism/collectivism.

Results

People from highly collective countries (China) perceive uncivil transgressors as immoral and enact more social control over them than people from highly individualistic countries (U.K.). They also experience more discomfort when facing uncivil transgressors, and this discomfort mediates the increasing immorality perceived on the agents of incivilities in contrast with people from less collective countries.

Discussion

Our findings provide insights into how cultural factors shape individuals’ perceptions of social norm violations and emphasize the importance of considering cultural differences when addressing incivility.
Mediating effect of depressive symptoms on the relationship between digital literacy and cognitive function in older adults
Authors: Hong Jae Woo , Nam You Jin , Hong Sunhwa , Roh Hyun Woong
Published: September 2023

Introduction

Although several studies have examined the individual relationships among digital literacy, cognitive function, and depressive symptoms, few have integrated all three factors into a single model. This study aimed to address this gap by investigating the mediating effect of depressive symptoms on the relationship between digital literacy and cognition. In doing so, we hoped to contribute to a more comprehensive understanding of the complex interplay among these variables and their implications for mental health and well-being.

Methods

Participants were 7,988 older adults (65 years or older) who participated in the Living Profiles of Older People Survey 2020. The main type of exposure was digital literacy (communication, information, media, and online transaction literacy). The main outcomes were depressive symptoms measured using the Short Geriatric Depression Scale of Korean version and cognitive function measured using the Mini-Mental State Examination score. Multiple linear regression and mediation analyses were also performed.

Results

After adjusting for covariates, our analysis found a significant association between digital literacy and both depressive symptoms and cognitive function (β of four types of digital literacy and depressive symptoms = −0.123, −0.172, −0.702, and − 0.639, respectively; β of four types of digital literacy and cognitive function = 2.102, 2.217, 1.711, and 1.436, respectively). Moreover, our study showed that depressive symptoms play a mediating role in the relationship between media and online transaction literacy and cognitive function (95% CI of indirect effects = 0.0647–0.1212 and 0.0639–0.1277, respectively), implying an indirect pathway (digital literacy, depressive symptoms, and cognitive function).

Discussion

This study sheds light on the relationship between digital literacy, depressive symptoms, and cognitive function in older adults. We found that depressive symptoms mediated the association between specific aspects of digital literacy (online transaction and media literacy) and cognitive function. Our results indicate that community-based digital literacy programs could be effective in reducing depression and preserving or improving cognitive function in older adults.
Technology adoption review for ageing well: analysis of technical solutions
Authors: Gambo Ishaya , Bueno-Delgado M. Victoria , Mooses Kerli , Melero Muñoz Francisco J. , Zviel-Girshin Rina , Andrushevich Aliaksei , Mrissa Michael , Landowska Agnieszka , Taveter Kuldar
Published: September 2023

While several technological solutions are available for older adults to improve their wellbeing and quality of life, little is known about the gaps between the needs, provided solutions, and their adoption from a more pragmatic perspective. This paper reports on reviewing existing technological solutions for older adults, which span the work life, life in the community, and wellbeing at home. We analyzed 50 different solutions to uncover both negative and positive features of these solutions from the perspective of the impact of technology adoption on the quality of life of older adults. Our approach harnesses holistic reasoning to determine the most suitable technologies available today and provides suggestions for improvement toward designing and implementing better solutions.
A machine learning approach to personalized predictors of dyslipidemia: a cohort study
Authors: Gutiérrez-Esparza Guadalupe , Pulido Tomas , Martínez-García Mireya , Ramírez-delReal Tania , Groves-Miralrio Lucero E. , Márquez-Murillo Manlio F. , Amezcua-Guerra Luis M. , Vargas-Alarcón Gilberto , Hernández-Lemus Enrique
Published: September 2023

Introduction

Mexico ranks second in the global prevalence of obesity in the adult population, which increases the probability of developing dyslipidemia. Dyslipidemia is closely related to cardiovascular diseases, which are the leading cause of death in the country. Therefore, developing tools that facilitate the prediction of dyslipidemias is essential for prevention and early treatment.

Methods

In this study, we utilized a dataset from a Mexico City cohort consisting of 2,621 participants, men and women aged between 20 and 50 years, with and without some type of dyslipidemia. Our primary objective was to identify potential factors associated with different types of dyslipidemia in both men and women. Machine learning algorithms were employed to achieve this goal. To facilitate feature selection, we applied the Variable Importance Measures (VIM) of Random Forest (RF), XGBoost, and Gradient Boosting Machine (GBM). Additionally, to address class imbalance, we employed Synthetic Minority Over-sampling Technique (SMOTE) for dataset resampling. The dataset encompassed anthropometric measurements, biochemical tests, dietary intake, family health history, and other health parameters, including smoking habits, alcohol consumption, quality of sleep, and physical activity.

Results

Our results revealed that the VIM algorithm of RF yielded the most optimal subset of attributes, closely followed by GBM, achieving a balanced accuracy of up to 80%. The selection of the best subset of attributes was based on the comparative performance of classifiers, evaluated through balanced accuracy, sensitivity, and specificity metrics.

Discussion

The top five features contributing to an increased risk of various types of dyslipidemia were identified through the machine learning technique. These features include body mass index, elevated uric acid levels, age, sleep disorders, and anxiety. The findings of this study shed light on significant factors that play a role in dyslipidemia development, aiding in the early identification, prevention, and treatment of this condition.
Diagnostic value of the cerebrospinal fluid lipoarabinomannan assay for tuberculous meningitis: a systematic review and meta-analysis
Authors: Chen Ya-Li , Zhu Meng-Meng , Guan Cui-Ping , Zhang Yan-An , Wang Mao-Shui
Published: September 2023

Objective

This systematic review aims to evaluate the diagnostic accuracy of cerebrospinal fluid (CSF) lipoarabinomannan (LAM) assays in detecting tuberculous meningitis (TBM).

Methods

A systematic review search was conducted in PubMed and five other databases up to April 2023. Studies that evaluated the diagnostic accuracy of CSF LAM assays were included with either definitive or composite reference standard used as the preferred reference standard. The quality of the included studies was assessed using the QUADAS-2 tool. We performed a bivariate random-effects meta-analysis and calculated the summary diagnostic statistics.

Results

A total of six studies, including a sample size of 999, were included in the final analysis. The pooled sensitivity, specificity, and area under the receiver operating characteristic curve (AUC) of CSF LAM for diagnosing TBM were determined to be 0.44 (95% CI: 0.31–0.58), 0.89 (95% CI: 0.81–0.93), and 0.76 (95% CI: 0.73–0.80), respectively. Significant heterogeneity was observed in both sensitivity (Q = 73.82, p < 0.01; I2 = 86.45, 95%CI: 79.64–93.27) and specificity (Q = 95.34, p < 0.01; I2 = 89.51, 95% CI: 84.61–94.42). Regression analysis indicated that the study design (retrospective vs. prospective) was associated with the heterogeneity of pooled sensitivity and specificity (all p < 0.05).

Conclusion

Although more prospective studies are required to validate the role of the CSF LAM assay, current evidence supports that the performance of the CSF LAM assay is unsatisfactory for the TBM diagnosis. Additionally, the optimization of the CSF LAM assay (e.g., improvements in CSF collection and preparation methods) should be considered to improve its performance.
Unaddressed regulatory issues in xenotransplantation: a hypothetical example
Authors: Kwisda Koko
Published: September 2023

The last few years have seen a significant increase in the use of technology to manipulate genetic sequences and generate animals as a source of xeno-organs. This has made the generation of genetically bespoke organisms a reality. This paper will analyze the regulatory and practical aspects of such an innovative approach to xenotransplantation on the basis of a hypothetical case study applied to Germany and highlight the gaps in the current regulation. This paper thus provides the basis for legal debate within a specific country. In addition, the identified gaps also pose a barrier toward the harmonization of international regulation. This publication therefore lays the groundwork for guiding the international debate regarding the regulatory framework for solid organ xenotransplantation toward specific issues.
Primary extraskeletal osteosarcoma of the post-hepatic caudal vena cava in a dog—Case report
Authors: Tremolada Giovanni , Griffin Lynn , Manchester Alison C. , Aboellail Tawfik , Lapsley Janis M. , Selmic Laura E.
Published: September 2023

Extraskeletal osteosarcoma (EOSA) in dogs is a rare malignant mesenchymal tumor of somatic soft tissues or more commonly visceral organs with a poor prognosis. In dogs, EOSAs have been described as arising from multiple locations, but differently from humans, never from a main vessel. In this report, we describe the first case of an EOSA arising from the post-hepatic caudal vena cava in a 7-year-old male neutered mix breed dog. This report focuses on the description of the diagnostic challenges to obtain a preoperative diagnosis, highlights the importance of histopathology for a correct diagnosis, and introduces a new differential diagnosis for an animal presenting with a suspected thrombus of the vena cava.
Effects of Yu-Ping-Feng polysaccharides on animal growth performance and immune function: a review
Authors: Chu Huangbin , Zong Yi , Yang Hong , Chen Siyu , Ma Zheng , Li Hua
Published: September 2023

Yu-Ping-Feng polysaccharides (YPF-P) is the primary component of Yu-Ping-Feng San (YPF-S) medicine prescription, which consists of three polysaccharides from Astragalus Membranaceus polysaccharide (AM-P), Atractylodes Macrocephala polysaccharide (AM-P), and Saposhnikovia Divaricata polysaccharide (SD-P). The use of Yu-Ping-Feng polysaccharides dates back to the Yuan Dynasty when Yilin Wei first utilized it. The remedy is included in “Effective Formulae Handed Down for Generations” and “The Pharmacopoeia of the People’s Republic of China.” Yu-Ping-Feng polysaccharides is known to promote growth and enhance the body’s immune function in animals. As such, it has promising application prospects in animal husbandry. This review mainly introduces the main components and characteristics of Yu-Ping-Feng polysaccharides, its effects on animal production, and its impact on animal immune function. Additionally, this paper offers a preliminary discussion on the development and utilization of Yu-Ping-Feng polysaccharides, laying the foundation for further research and application. This review may also provide insight and reference for the development of the farming industry, reducing production costs and improving productivity.
Cutting-edge knowledge on the roles of phytobiotics and their proposed modes of action in swine
Authors: Pandey Sriniwas , Kim Eun Sol , Cho Jin Ho , Song Minho , Doo Hyunok , Kim Sheena , Keum Gi Beom , Kwak Jinok , Ryu Sumin , Choi Yejin , Kang Juyoun , Choe Jeehwan , Kim Hyeun Bum
Published: September 2023

With the ban on antibiotics in the swine industry, the exploration of alternative options has highlighted phytobiotics as a promising substitute for antibiotic growth promoters, aiming to foster a more sustainable swine industry. Phytobiotics are non-nutritive natural bioactive components derived from plants that offer numerous health benefits. They exhibit antioxidative, antimicrobial, and anti-inflammatory effects. Phytobiotics can be utilized in various forms, including solid, dried, ground, or as extracts, either in crude or concentrated form. They are characterized by low residual levels, a lack of resistance development, and minimal adverse effects. These qualities make phytobiotics an attractive choice for enhancing health and productivity in swine, presenting them as a viable alternative to antibiotics. While there is a general understanding of the effects of phytobiotics, there is still a need for detailed information regarding their effectiveness and mechanisms of action in practical settings. Therefore, the purpose of this mini review was to summarize the current knowledge supporting the roles of phytobiotics and their proposed modes of action, with a specific focus on swine.
An Information Theoretic Approach to Privacy-Preserving Interpretable and Transferable Learning
Authors: Kumar Mohit , Moser Bernhard A. , Fischer Lukas , Freudenthaler Bernhard
Published: September 2023

In order to develop machine learning and deep learning models that take into account the guidelines and principles of trustworthy AI, a novel information theoretic approach is introduced in this article. A unified approach to privacy-preserving interpretable and transferable learning is considered for studying and optimizing the trade-offs between the privacy, interpretability, and transferability aspects of trustworthy AI. A variational membership-mapping Bayesian model is used for the analytical approximation of the defined information theoretic measures for privacy leakage, interpretability, and transferability. The approach consists of approximating the information theoretic measures by maximizing a lower-bound using variational optimization. The approach is demonstrated through numerous experiments on benchmark datasets and a real-world biomedical application concerned with the detection of mental stress in individuals using heart rate variability analysis.
Seasonal Pollinosis Due to Kans Grass Pollen: Prevalence and Immune-Biochemical Approach
Authors: Basak Tanmoy , Bhattacharya Kashinath
Published: September 2023

Background: It has been recognized from the early days of allergology that aerobiological investigations have an important role to play in the development of respiratory allergic diseases. An increasing number of allergic complaints occurred among the atopic population during the blooming season of Kans grass, Saccharum spontaneum (SS), an obnoxious weed growing in and around suburban West Bengal. The present study aimed to identify SS pollen as a potential aero allergen through aerobiological, clinical, statistical, and biochemical analyses. Methods: An aerobiological survey was conducted for 2 years followed by a clinical diagnosis of 134 local atopic patients suffering from a respiratory allergy by a standard questionnaire survey and the skin prick test (SPT) using SS antigens. The antigenic protein profile was analyzed by SDS-PAGE and the allergizing potential of this pollen was investigated by an in vitro enzyme-linked immunosorbent assay to recognize the presence of the sero-reactive proteins which were the suspected cause of the respiratory allergy. A Box-plot and regression analysis were performed to establish the significance of clinical data. Results: SS pollen was found to evoke about 70.14% sensitivity among the atopic population causing early spring hay fever, allergic rhinitis, and seasonal allergic conjunctivitis. A regression analysis for the pollen antigen for estimating the total IgE value of a patient’s sera from their specific IgE value was a novel approach by our study. The antigenic extract of pollen resolved into more than 15 distinct protein bands ranging from 14.4 to 116 kDa, some of which were found to be glycosylated. The results showed that SS pollen has a significant presence in the atmosphere, which may trigger an allergic response in immunocompromised patients. Conclusions: This is, to our knowledge, the first attempt to identify allergens from Kans pollen causing seasonal pollinosis among the Indian atopic population using an immuno-clinical approach.
The Influence of Grassland Ecological Compensation Policy on Grassland Quality: Evidence from the Perspective of Grassland Ecosystem Vulnerability
Authors: Liu Mengmeng , Wu Wanqing , Li Hua
Published: September 2023

The grassland ecological compensation policy (GECP) is currently the largest grassland ecosystem payment program in the world, trying to manage and restore degraded grasslands to achieve a virtuous cycle of grassland ecosystems. However, responses to the policy may vary across different regions. Based on panel data from 395 counties in six provinces in China’s pastoral areas from 2001 to 2021, this paper uses the difference-in-difference (DID) and moderation effect models to test the relationship between GECP and grassland quality from the perspective of grassland ecosystem vulnerability. The study found the following: (1) The spatial differentiation pattern of grassland ecosystem vulnerability in the six provinces of China’s pastoral areas is obvious, and the vulnerability is mainly slight and moderate (2) The GECP generally has a significant positive impact on grassland quality. (3) Grassland ecosystem vulnerability has a negative regulatory effect on the impact of the GECP on grassland quality. The positive impacts of policies become more pronounced as the vulnerability of grassland ecosystems decreases.