bluuebunny/crossref_metadata_2025 huggingface dataset:
Study of the Membrane Activity of the Synthetic Peptide ∆M3 against Extended-Spectrum β-Lactamase Escherichia coli Isolates
Authors: Fandiño-Devia Estefanía , Santa-González Gloria A. , Klaiss-Luna Maria C. , Manrique-Moreno Marcela
Published: October 2023

Escherichia coli is the most common microorganism causing nosocomial or community-acquired bacteremia, and extended-spectrum β-lactamase-producing Escherichia coliisolates are identified worldwide with increasing frequency. For this reason, it is necessary to evaluate potential new molecules like antimicrobial peptides. They are recognized for their biological potential which makes them promising candidates in the fight against infections. The goal of this research was to evaluate the potential of the synthetic peptide ΔM3 on several extended-spectrum β-lactamase producing E. coli isolates. The antimicrobial and cytotoxic activity of the peptide spectrophotometrically determined. Additionally, the capacity of the peptide to interact with the bacterial membrane was monitored by fluorescence microscopy and infrared spectroscopy. The results demonstrated that the peptide is active against Escherichia coli isolates at concentrations similar to Meropenem. On the other hand, no cytotoxic effect was observed in keratinocyte cells even at 10 times the minimal inhibitory concentration. Microscopy results showed a permeabilizing effect of the peptide on the bacteria. The infrared results showed that ΔM3 showed affinity for the lipids of the microorganism's membrane. Finally, the peptide showed a random structure in solution that did not change during the interaction with the membranes.
The synthetic peptide ΔM3 was demonstrated to have potential antimicrobial activity against β-lactamase-producing E. coli isolates, and low cytotoxicity against HaCaT cells. The results suggest that the ∆M3 interacts with the negatively charged lipids from the E. coli by a disturbing effect on membrane. The secondary structure showed no conformational change for ∆M3.
Coastal populations experience sea level rise at least twice as large as the global average
Authors: Oelsmann Julius , Nicholls Robert , Lincke Daniel , Marcos Marta , Sánchez Laura , Dettmering Denise , Hinkel Jochen , Horton Benjamin , Seitz Florian
Published: October 2023

Coastal subsidence can significantly increase rates of relative sea level change over and above climate-related changes, and has been reported to be particularly large in densely populated regions. However, due to the small scale variability of vertical land motion (VLM) and the sparsity of VLM observations, there is currently still low confidence in VLM and the uncertainties this introduces in sea level change estimates. Therefore, we synergize currently available VLM observations (from GNSS, InSAR, tide gauges, and satellite altimetry) to investigate the impact of VLM on relative sea level changes and their uncertainties, as well as the implications for coastal populations. We find that the average contemporary (1995-2019) global relative sea level change experienced by coastal populations (5.14 mm/year) is more than twice as large as the average coastal relative sea level change (2.09 mm/year). This is because rates of subsidence tend to be higher in densely populated areas. A significant part of the coastline (representing 40% of the coastal population) lacks measurements or access to the direct measuring stations which are necessary to constrain VLM rates estimated with InSAR. Missing, or imprecise VLM constraints contribute to the increased population-weighted uncertainties in the relative sea level change trends of ~3 mm/year. Thus, future community efforts are needed to improve the observational database in the disproportionately exposed and densely populated coasts in order to reduce uncertainties in estimates of future relative sea-level rise and their societal implications.
Efficacy of Farsan Ventilation Equipment (FVE) on Oxygenation and End-Tidal Carbon Dioxide During Cataract Surgery under Local Sedation: A Randomized Clinical Trial
Authors: Farsani Hamidreza Azizi , Tafrishinejad Arash , Hassanpour Kiana , Farsani Zahra Azizi , Farsani Abolfazl Azizi , Karjou Zahra
Published: October 2023

Background:
This study aimed to investigate the efficacy of novel ventilation equipment on oxygenation and end-tidal carbon dioxide levels during cataract surgery under local anesthesia.
Methods:
A total of two hundred patients undergoing cataract surgery under local anesthesia were included in this randomized controlled trial. Patients were randomly assigned to receive local anesthesia using Farsan Ventilation Equipment (FVE) on their chest during the procedure, while the control group received oxygen through a nasal cannula (NC). The primary outcome measures were end-tidal CO2 (EtCO2) and the fraction of inspired carbon dioxide (FICO2). The secondary outcome measures included peripheral arterial O2 saturation (SpO2), the patient's respiratory rate, heart rate, and mean arterial pressure.
Results:
The mean surgery time was 35.5 ± 7.05 minutes in the NC group and 38.2 ± 6.2 minutes in the FVE group. The FVE group showed significantly lower levels of EtCO2 and FICO2 and higher SpO2 compared to the NC group during the operation. In the FVE group, SpO2 remained stable at high levels, and there was no increase in EtCO2 and FICO2 during the operation. Additionally, the FVE group exhibited significantly lower respiratory rate (RR), heart rate (HR), and mean arterial pressure (MAP) compared to the NC group.
Conclusion:
Farsan Ventilation Equipment (FVE) is easy to handle and proves helpful in preventing carbon dioxide accumulation, carbon dioxide rebreathing, unwanted tachypnea, and patient exhaustion. It is particularly beneficial for practical use in elderly patients undergoing eye surgery under local anesthesia.
Trial Registration Code: The trial is registered at https://irct.ir/ with the code IRCT20210216050379N2. Further details can be found at https://fa.irct.ir/trial/55786/pdf.
SPP1 promotes brain metastasis of NSCLC by up-regulating PI3K/AKT/mTOR pathway
Authors: Li Xiaoqin , Wu Yun , Yue Wenxiang , Lin Ming , Li Hongru , Lin Ying , Chen Yusheng
Published: October 2023

Purpose
Brain metastasis (BM) is a significant contributor to poor prognosis in patients with non-small cell lung cancer (NSCLC). Secreted phosphoprotein 1 (SPP1) is involved in the progression and metastasis of various cancers. However, the role of SPP1 in NSCLC, particularly in NSCLC BM, remains unclear. This study aimed to identify genes associated with NSCLC BM and investigate the involvement of SPP1 in NSCLC BM.
Methods
Integrated genomic analysis was used to identify candidate genes in NSCLC. Expression levels of SPP1 were evaluated in NSCLC tumor tissues and cell lines. In vitro and in vivo experiments were conducted to assess the impact of SPP1 on NSCLC cell behavior and BM. The underlying mechanism involving the PI3K/AKT/mTOR pathway was explored.
Results
SPP1 expression was found to be elevated in NSCLC tissues and cell lines. SPP1 depletion using shRNA inhibited cell proliferation, migration, and invasion in vitro and suppressed BM in vivo. Mechanistically, SPP1 partly influenced NSCLC progression through the PI3K/AKT/mTOR signaling pathway. Moreover, immunohistochemical staining demonstrated that SPP1 expression was higher in NSCLC tissues with BM than in those without BM. Furthermore, elevated SPP1 expression was associated with poor clinical outcomes in patients with NSCLC.
Conclusion
This study highlights the role of SPP1 as a regulator of cell metastasis and suggests its potential as a novel therapeutic target for BM in NSCLC.
Sustainable Tourist Behaviour: Role of Destination Social Responsibility and Tourist Value Orientation
Authors: Khaki Aijaz Ahmad , Mir Aaqib Bashir
Published: October 2023

The authors have requested that this preprint be removed from Research Square.
STRABO AND DIODORUS ON THE PHYSICAL BARBARITY OF THE IBERIANS
Authors: КАМАРИ Д.М.
Published: October 2023

Античные авторы неосознанно под этнонимом «иберийцы» называли разные этнические группы, которые проживали на территории Пиренейского полуострова. Эти этнические группы отличались друг от друга происхождением, традициями и уровнем культурного и социально-экономического развития. В источниках большая часть жителей этого далеко региона представлена дикими и неукротимыми. Однако жители юга Пиренейского полуострова, в отличие от населения внутренних областей, имели письменность и развитую систему торговых связей. По мнению автора, слава о дикости и варварских традициях иберийцев связана с кельтами, которые в конце VI в. до н.э. распространились по большей части Пиренейского полуострова, нападая на богатые финикийские города.

The ancient authors used the ethnonym Iberians for different ethnic groups that lived in the territory of the Iberian Peninsula. These ethnic groups differed from each other in origin, traditions and level of cultural and socio-economic development. In the sources, most of the inhabitants of this far region are wild and indomitable. However, the inhabitants of the south of the Iberian Peninsula, unlike the population of the interior, had a written language and a developed system of trade relations. According to the author, the fame of the savagery and barbarian traditions of the Iberians is associated with the Celts, who at the end of the 6th century BC spread throughout most of the Iberian Peninsula, attacking the wealthy Phoenician cities.
IMMANIS AND IMMANITAS AS APPLIED TO THE BARBARIANS IN THE USE OF CICERO
Authors: НИКИШИН В.О.
Published: October 2023

Семантический диапазон прилагательного immanis в словоупотреблении Цицерона довольно широк — от нейтрального «огромный» до унизительного «грубый». Характерно, что эпитет immanis с уничижительно-грубым и оскорбительным подтекстом Цицерон применяет по отношению не только к варварам, но и к своим личным врагам или оппонентам из числа римлян, т.е. носителей полисной цивилизации. Таким образом, варварство в худших своих проявлениях проникло в пространство античной культуры. Можно сказать, что вербальное варварство в известном смысле породнило римлян и варваров. То же самое относится и к существительному immanitas, которое может означать множество или толпу, но чаще всего — варварство в самых неприглядных его проявлениях. Все эти негативные качества, объединённые понятием immanitas, как и в случае с эпитетом immanis, применимы к некоторым представителям античной цивилизации в не меньшей степени, чем к «природным» варварам. Так этнолингвистический характер феномена «варварство» как бы переводится Цицероном в культурно-этическую, нравственную плоскость.

The semantic range of the adjective immanis in Cicero's usage is quite wide — from the neutral «huge» to the derogatory «rude». It is characteristic that Cicero uses the epithet immanis with a derogatory, rude and insulting connotation in relation not only to barbarians, but also to his personal enemies or opponents from among the Romans, i.e. carriers of the polis civilization. Thus, barbarism in its worst manifestations penetrated into the space of ancient culture. It can be said that verbal barbarism, in a certain sense, related the Romans and the barbarians. The same applies to the noun immanitas, which can mean a multitude or a crowd, but most often — barbarism in its most unsightly manifestations. All these negative qualities, united by the concept of immanitas, as in the case of the epithet immanis, are applicable to some representatives of ancient civilization to no lesser extent than to «natural» barbarians. Thus, the ethno-linguistic nature of the phenomenon of «barbarism» is, as it were, translated by Cicero into a cultural, ethical, moral plane.
Physical restraints practice in adult intensive care units: a review
Authors: Gorbachev Vladimir I. , Bragina N. V. , Netesin E. S. , Petrova I. L. , Gorbachev S. V.
Published: October 2023

OBJECTIVE: To describe the available evidence on indications, complications, care and alternative strategies in the use of physical restraint in adult patients in Intensive Care Units. MATERIALS AND METHODS: An integrative review conducted in the Cochrane, PubMed, Scopus, LILACS, Nursing Database and the eLibrary portal. The search was performed on the queries: “physical restriction”, “fixation devices in intensive care”, “patient safety”, “fixation of the patient”. RESULTS: The final selection was of 93 articles, from which the indications, complications, care and alternative strategies were extracted. CONCLUSIONS: The most common practices regarding physical restraints in Russia and foreign countries were described, and the need for the elaboration and implementation of protocols on intervention to support decision — making was observed.
Cyclosporine A therapy in patients with COVID-19 and failure of immunosuppression therapy: a retrospective cohort propensity-score matched analysis
Authors: Merzhoeva Z. M. , Yaroshetskiy A. I. , Savko S. A. , Krasnoshchekova A. P. , Mandel Irina A. , Tsareva N. A. , Trushenko N. V. , Nuralieva G. S. , Avdeev S. N.
Published: October 2023

INTRODUCTION: Therapy of COVID-19 patients with progressive lung damage after the use of glucocorticosteroids (GCS) and interleukin-6 inhibitors (IIL-6) has not yet been developed. OBJECTIVE: Assessment of the effectiveness of cyclosporine A in patients with COVID-19 with progression of lung damage and hypoxemic acute respiratory failure, who received therapy with GCS and IIL-6. MATERIALS AND METHODS: A retrospective cohort propensity-score matched analysis (n = 98). Cyclosporine A was prescribed in the first 72–96 hours after IIL-6 administration when the patient's condition worsened. The patients of comparison group corresponded to the study group, but did not receive cyclosporine A therapy. The primary end point was in-hospital mortality. Secondary endpoints — duration of hospitalization, number of patients admitted to the intensive care unit (ICU), need for respiratory support. RESULTS: Mortality was 12 (22) % in the cyclosporine group and 27 (61) % in the comparison group, р = 0.001 (hazard ratio [HR] 2.00 (1.12–3.48), р = 0.018), ICU admission rate 14 (26) % vs 29 (66) %, р = 0.001, respectively. In the cyclosporine group on day 7 CT-4, there were 26 % of patients vs 52 % in the control group, р = 0.014, the need for respiratory support (37 % vs 63.6 %, р = 0.011); saturation 88 % (82–93) vs 80 % (70–86), р = 0.001, respectively. The need for respiratory support at day 11 after IIL-6 increased the likelihood of death (HR 7.10 (2.5–20), р = 0.001). Risk factors for death: age over 57.5 years, body mass index over 30 kg/m2, hemoglobin oxygen saturation below 85.5 % on the day of IIL-6 application. Duration of hospitalization was 18.5 (14–24) days vs 18 (12–24) days, р = 0.778. CONCLUSIONS: Cyclosporine A in addition to GCS and IIL-6 for COVID-19 therapy may reduce mortality, ICU admissions, and respiratory support requirements.
The ultrasound assessment of the inferior vena cava collapsibility in the prone volunteers through a new acoustic window: a prospective observational study
Authors: Kasatkin Anton A. , Matreshkin V. A.
Published: October 2023

INTRODUCTION: Ultrasound assessment of inferior vena cava (IVC) collapsibility is used in clinical practice to assess patients' volume status. Finding the subject in the prone position limits the ability to assess IVC collapse by the traditional method, which requires the use of alternative methods. OBJECTIVE: Conducting a comparative assessment of the IVC collapse index in healthy volunteers in the back position and in the pro position using a new acoustic window. MATERIALS AND METHODS: Ultrasound observation was performed in 25 adult healthy volunteers of both sexes. Ultrasound measurement of IVC was carried out sequentially in the position of volunteers on the back and abdomen. The mean (M) and standard deviation (SD) of the maximum and minimum IVC size. The values of the collapsing index (CI) obtained during the study are presented as a median (Me) and quartiles (Q1–Q3). Wilcoxon's nonparametric test was selected for comparative analysis (significance level accepted 0.05). RESULTS: Measurements of the diameter of the inferior vena cava obtained the following results: the average maximum and minimum vein size in volunteers in the supine position were 1.58 ± 0.37 cm and 1.30 ± 0.36 cm, respectively; in prone — 1.51 ± 0.37 cm and 1.24 ± 0.36 cm, respectively. Me (Q1–Q3) IVC-CI values (%) in volunteers in the supine and in the prone position of the voice were 16.84 (8.86–24.39) and 15.63 (10.23–24.77), respectively. Statistical analysis of the obtained results did not reveal a significant difference between CI values (p = 0.861). CONCLUSIONS: The absence of a statistically significant difference in IVC-CI values in the supine and abdominal volunteers demonstrates the possibility of using a new acoustic window to assess volume status in the clinical setting in patients in the prone position.
The effect of a tyrosyl-D-alanyl-glycyl-phenylalanyl-leucyl-arginine diacetate (Dalargin) on oxidative stress in patients with severe combined trauma: a prospective clinical study
Authors: Antonova V. V. , Evseev A. K. , Goroncharovskaya I. V. , Ryzhkov A. Yu. , Grebenchikov Oleg A. , Shabanov A. K.
Published: October 2023

INTRODUCTION: Severe combined trauma remains the leading cause of mortality and disability of the workable population. Under damaging factor influence, a whole cascade of pathological processes is triggered, leading to development of multiple organ failure. OBJECTIVE: Exploration of the effects synthetic analogue of tyrosyl-D-alanyl-glycyl-phenylalanyl-leucyl-arginine diacetate (Dalargin) on the dynamics of oxidative stress markers in patients with severe polytrauma and the development of organ dysfunction. MATERIALS AND METHODS: 104 patients with severe combined trauma were included in study. There were 38 patients in the Dalargin group and 66 patients in the control group. Patients from main group received Dalargin in the form of a constant infusion through a syringe dispenser at the dose of 10 mcg/kg/hour at first 12 hours of hospitalization and 5 mcg/kg/hour up to 72 hours from the moment of admission. The control group received standard treatment. Indicators of oxidative stress were evaluated at the time of admission (0 days), 1, 3, 5, 7, 10 and 14 days from the therapy onset. RESULTS: In the main group, there was a significant decrease in oxidative stress markers such as malondialdehyde from the first day of treatment (p < 0.05), normalization of stable nitric oxide metabolites at day 10, and a decrease in total antioxidant activity below normal throughout the observation period. Mortality was comparable in both groups (p > 0.05), but the length of hospital stay was lower in surviving patients in the Dalargin group (p < 0.05). The development of organ dysfunction (acute respiratory distress syndrome, acute kidney injury) was less frequent in the Dalargine group (p < 0.05), but infectious complications (pneumonia, meningitis, wound suppuration) were comparable. CONCLUSIONS: Dalargin leads to a decrease of oxidative stress markers and normalization of endothelial function indicators, which contributes to a decrease of organ dysfunction frequency.
ESTRUTURA DE GOVERNANÇA PARA ENFRENTAMENTO DA PANDEMIA DA COVID-19: ESTUDO DE CASO NA SES/MG
Authors: Meneghini Vale Larissa , Campos Vanessa , Gonçalves da Cruz Marcus Vinicius
Published: October 2023

O artigo analisa o processo de mudança ocorrido com a implementação da estrutura de governança na Secretaria de Estado de Saúde de Minas Gerais (SES/MG) para o enfrentamento da pandemia da COVID-19. A partir da mobilização de referências teóricas de mudança organizacional e governança pública, realizou-se pesquisa qualitativa, por meio de estudo de caso, comparando aos parâmetros de governança delineados pelo Tribunal de Contas da União (TCU). Os achados indicam que a inovação da SES/MG se deu com o estabelecimento de nova estrutura de governança, definiu-se o nível de decisão estratégica, incorporou novos atores no processo, incentivou o fluxo de informações e seu compartilhamento, e aprimorou a utilização de facilities existentes. Concluiu-se que a mudança com introdução da nova estrutura mostrou-se aderente aos elementos de governança do TCU, contribuindo para uma resposta efetiva à pandemia por instituição do Sistema Único de Saúde brasileiro.
COMO A SECRETARIA MUNICIPAL DE SAÚDE DE MANAUS EXECUTOU AS DESPESAS INERENTES AO ENFRENTAMENTO DA PANDEMIA DE COVID-19 NO ANO DE 2020?
Authors: Da silva Williane Gama , Escate Lay Eduardo Genaro , Lasmar Cruz Rosa Cláudia , De Souza Ederson Almeida
Published: October 2023

Problematizou-se: Como a Secretaria de Saúde de Manaus (SEMSA) executou despesas da pandemia de COVID-19 em 2020? Objetivou analisar a execução de despesas da SEMSA com a pandemia por meio destes objetivos específicos: levantar metas da Programação Anual de Saúde (PAS) de 2020; verificar percentuais de execução das metasdos indicadores de pactuação interfederativa do Relatório Anual de Gestão (RAG) de 2020; coletar informações quali-quantitativas sobre a execução de despesas com o enfrentamento pandêmico nos demonstrativos contábeis do RAG/2020; e apontar metas de Atenção de Saúde Básicas impactadas pela priorização das ações de enfrentamento da pandemia de COVID-19. Metodologicamente, trata-se de pesquisa descritiva que analisou os financiamentos das ações de saúde pública de Manaus e a variação, execução e efetividade das despesas com o enfretamento da pandemia em 2020. Resultados: cumprimento da obrigatoriedade de detalhar as despesas ao enfrentamento da pandemia pela municipalidade estudada. Identificou-se que os créditos extraordinários destinados à aplicação de despesas da referida pandemia encontraram amparo nos Decretos Municipais n.os 4.838/2020, 4.849/2020 e 4.873/2020.
Sensuality Representation Of Guinness Dark Beer Advertising
Authors: Migotuwio Namuri , Ika Indrayati Refita , Wisnu Wijaya P.G.
Published: October 2023

This study examines the rhetorical meaning of "stout" dark beer advertising photos  with the Guinness trademark presented with a sensuality approach. Roland Barthes' semiotics is used to reveal symbolic meaning in advertising. In addition, to explain the concept of secrecy and the psychological aspects implied in the advertisement elaborated using Lacan's psychoanalytic theory. Based on an in-depth analysis, it was concluded that the sensuality approach through bodily on Guinness dark beer advertising posters was considered in line with the spirit of the company that wanted to present an elegant, masculine impression and able to accommodate the cultural spirit of patriarchal society in Ireland and the world. In addition, the use of legs and the use of black are considered to be able to represent the history of the slave trade in Ireland and express the discourse of sensuality that developed in the country. Visualization with digital imaging techniques is a  bridge to the ideological conflict between sensuality as a concept that is still considered taboo by society and advertising as a medium for commodification of Guinness products.
Designing User Interface (UI) & User Experience (UX) Mobile Website Templates Digital Wedding Invitations
Authors: Siregar Parlindungan , Haswanto Naomi
Published: October 2023

Wedding invitations have been using the conventional way, with paper. Costs are not cheap, invitation printing takes a long time, and environmental issues in the use of paper. Wedding invitations no longer use paper media. Wedding invitations with user interface (UI) and user experience (UX) designs provide a new experience. UI/UX design is an important stage because it gives an initial impression to potential users. The design of digital wedding invitations uses a design thinking method approach which is consists of several stages, namely empathize, define, ideate, prototype, and testing. Empathize process using questionnaires and interviews. Respondents to the questionnaire were 92 people with an age range of 25 to 35 years and had a middle to upper economic level.Apart from being well educated, the respondents are active internet users. The results showed that respondents preferred the simple modern invitation design style. In the define process, users need several digital wedding invitation templates with international and traditional nuances. It is designed to be interactive, user friendly, and has features that can be customized. Furthermore, the ideation process is carried out based on the analysis of the define process, namely the design of mobile website templates for digital wedding invitations. Bride and groom are made easy with several template choices. The prototype process is carried out by getting the initial design, then testing it and doing it iteratively to get feedback from the bride and groom in order to get the digital wedding invitations that the bride and groom need.
Managing Corporate Reputation, Stakeholder Relations, and Corporate Social Responsibility Using Best Practice Public Relations Strategy: A Nigerian Perspective
Authors: O. A Abraham
Published: October 2023

Studies have proven that the reputation of any organisation is an aftermath of a robust relationship between that organisation and its stakeholders. The relationships that exist between these stakeholders are also on the grounds of the interrelationship existing between the organisation and its publics and the social behaviour of the organisation and the stakeholders who are also the publics of an organisation thereafter. For this reason, an organisations’ reputation among its stakeholders is in accordance with the treatment the organisation gives its publics that translate into a corporate image and then to corporate reputation which on the whole informs the reputation the stakeholders would have later. The purpose of this paper is to identify the managerial role of managing corporate reputation, stakeholder relations, and corporate social responsibility of an organisation especially in Nigeria. The relationships that exist between these three key concepts; corporate reputation, stakeholder relations, and corporate social responsibility from a managerial perspective of corporate public relations strategies identifies and places organisations in the eyes of their publics as reputable. The study is relying on the postulation of the stakeholder theory which attempts to present a model that looks at who or what really is of essence. It hinges on the assumption that organisations, whether private or public, have an obligation to serve groups that constitutes into that organisation’s publics. Keywords: Social Responsibility, Corporate Reputation, Corporate Stakeholders, Public Relations.
Survival of Partial Laminate Veneers and Categorical Covariates Affecting the Survival: A Systematic Review
Authors: Çötert İrem , Çötert H. Serdar
Published: October 2023

Background:

Partial laminate veneers (PLV) have been accepted widely among both clinicians and patients with their favorable specifications, such as conservativeness, superior esthetics, bond strength and durability, for three decades. Various esthetic and functional impairments spreading in a wide range may be restored with veneers instead of full contour crowns.

Objective:

Although advantages, partial laminate veneers are not free from complications and various factors can influence the service duration of these restorations.

Methods:

An electronic Pubmed/Medline and Google Academic search was conducted without time restriction, providing information on porcelain laminate veneer’s failure rate and survival. Assessment of the identified studies was performed by two independent reviewers. Clinical service durations and various types of failures were evaluated.

Results:

Debonding, fracture, discoloration of the porcelain; staining or disintegration of tooth-porcelain margin; hypersensitivity, secondary caries, pulp necrosis and the periodontal responses were the more frequently studied failures. The mean CFR was found as 8,22% per study. Enamel substrate, incisal overlapping and lithium disilicate veneers presented lower failure rates in comparison with dentine substrate, non-overlapping and feldspathic veneers.

Conclusion:

PLV’s have high survival rates. The overall survival of PLV restorations can be affected by several prognostic variables.
Keeping the Swing on Par: Golfers and Upper Extremity Injuries they Face
Authors: Parikh Harin , Phillips Andrew , Stone Michael , Yoshida Ryu , McCullough Meghan , Herman Mojca , Shin Steven
Published: October 2023

Golf is a sport enjoyed by a rapidly growing population. While it is perceived as a low-demand activity, golf and its thousands of high-energy rotational swings can result in a plethora of upper extremity injuries. We examine the biomechanics of the golf swing and carry out a review, divided by anatomical region of the upper extremity (shoulder, elbow, forearm, wrist, and hand), of common injuries associated with golf. Part I of this review details the shoulder and elbow pathology seen in golfers, while Part II covers the forearm, wrist, and hand injuries associated with the sport. PubMed was searched for articles using terms that corresponded to the specific injury and golf. Additional data was obtained via outside journal searches that did not appear in PubMed. This is a clinical review. Specific phases of the golf swing place golfers at risk for unique injuries that may affect either the leading (left side in a right-handed golfer) or trailing (right side in a left-handed golfer) extremity. Amateur and professional golfers are at higher risk for different injuries, as pros are more likely to suffer overuse injuries, while amateurs may have injuries secondary to improper grip or swing form. We identify and comment on six shoulders, two elbow, eight forearm and wrist, and three hand injuries associated with golf. Current trends in management, as well as golf-specific rehabilitation and return to sport timelines, are discussed for each injury. Growing participation and an aging population make golf a common source of upper extremity injury. We delineate 19 of the most common upper extremity injuries that golfers face and equip providers with up-to-date information to appropriately diagnose, manage, and rehabilitate these injuries.
The Activity of α-glucosidase Inhibition of Pediococcus Acidilactici BAMA 4 Isolated from “Naniura” Traditional Foods from North Sumatera, Indonesia
Authors: Riastawaty Dewi , Girsang Ermi , Fachrial Edy , Ginting Chrismis Novalinda , Piska Finna , Nasution Ali Napiah
Published: October 2023

Background:

Type 2 diabetes is caused by unhealthy lifestyles, such as consuming foods rich in simple sugars and lack of exercise. One of the treatment therapies for this disease is α-glucosidase inhibitors. Some strains of the lactic acid bacteria (LAB) group typically exhibit α-glucosidase inhibitory activity, antimicrobial activity, acids and bile salt tolerance, and probiotic status.

Objective:

This study aims to isolate LAB from naniura, characterize and test its activity as an α-glucosidase inhibitor, as well as identify those with the highest activity.

Methods:

The method used to molecularly identify potentially good LAB was through the amplification of the 16S rRNA gene.

Results:

This study obtained a total of 9 strains using BAMA codes 1, 2, 3, 4, 5, 6, 7, 8, and 9. The cocci cell activity, gram-positive, and antibacterial activity of BAMA 4 against E.coli was 7.54 mm, while against S. aureus was 8.05 mm. The percentage of viability in acid and bile salt is 28.7% and 68.6%, respectively. Additionally, the proportion of α-glucosidase inhibition is 65%.

Discussion:

The BAMA 4 strain is a species of Pediococcus acidilactici. Pediococcus is a genus of gram-positive lactic acid bacteria in the Lactobacillacea family.

Conclusion:

BAMA 4 strain produced antibacterial optimally and its cells survived the growth in acid and bile conditions. The percentage of probiotics was relevantly high in this activity. This study will be helpful for other in-vivo research.
Can Gratitude Become a Religiosity Mediator on Employee Job Satisfaction?
Authors: Winarsunu Tulus , Aminuddin Riskun Karim , Djudiyah  , Anwar Zainul
Published: October 2023

Aims:

This study aimed to determine the role of gratitude as a mediator between the influence of religiosity on employee job satisfaction

Methods:

Quantitative research design with purposive sampling technique on 40 Primagroup Indonesia employees. Data were collected using the Religiosity Scale, Minnesota Satisfaction Questionnaire, and Gratitude Scale, distributed directly to the respondents. Data analysis used Mediation Regression Analysis with the help of the SPSS version 26 program.

Results:

The test results of the direct influence of religiosity on job satisfaction were not significant (β = 0.10; p = 0.56 (p > 0.05)), meaning that hypothesis 1 was rejected. These results show that there is no direct influence of religiosity on job satisfaction when a gratitude mediator is presented. The results of the gratitude test as a mediator of the influence of religiosity on job satisfaction showed significant results (β = 0.23; p = 0.04 (p < 0.05)), which means that hypothesis 2 is accepted.

Conclusion:

The results showed that gratitude could mediate the effect of religiosity on employee job satisfaction. Gratitude can fully mediate the influence of religiosity on employee job satisfaction. So employees who have religiosity will feel more satisfied with their workers if through gratitude.
Sutika Paricharya - Post Natal Care in Ayurveda
Authors: Anudeepa Nath  , Dipak Kumar Goswami
Published: October 2023

Ayurveda gives importance to the care of women at every stage of life like during Rajasvala (during menstruation), Garbhini (during pregnancy) and Sutika (during puerperium). A postnatal period beginning immediately after the expulsion of placenta and extending up to 12 weeks, otherwise puerperium, puerperal period. In Ayurveda puerperial period is called Sutika Kala and postnatal care is named as Sutika Paricharya. During delivery due to loss of blood and other important Dhatus of body a Sutika becomes more prone to disease; therefore, she needs special and proper care which also ensures the healthy child to grow in a healthy way. Archaryas have explained 74 types of Sutika Roga which occurs due to improper Sutika Paricharya, Apatarpana, Vata Prakopa, Dhatu Ksheenata. Prognosis of Sutika Roga is incurable or difficult to cure as purifying measures are contraindicated in this stage. Sutika Paricharya includes the regimen that helps the women to regain her vitality and helps her body to revert back in pre-pregnant state. Three factors have been emphasized that is Dhatu Pratipurnata, Sharira Samavasthita, Sanchita Rudhira Yoni for which Acharyas have mentioned certain Ahara, Vihara, Aushadi, Yogasana, some Pathya and Apathya.
Management of Vatarakta with Yashtyahwa Niruha Basti: A Case Study
Authors: Neha Chaudhary  , Shweta Mishra
Published: October 2023

Convenience and busy schedules have become typically major issues in today’s society, with unhealthy food habits and sedentary lifestyle, leading to increase in various types of health issues day by day. Vatarakta is a disease explained in Ayurveda, in which derangement of metabolism occurs due to indulgence in unwholesome dietary habits and sedentary lifestyle. It occurs when both Vata and Rakta are vitiated by distinct etiological factors.[1] Initially vitiated Vata obstructs the path of vitiated Rakta and then gets obstructed by Rakta itself. It can be correlated with Gout due to similarity in the clinical presentation. Various Ayurvedic drugs and Panchakarma procedures have been proved useful for this disease. Here is a case of Vatarakta, which was treated for 16 days with Yashtyahwa Niruha Basti.[2] Observations and results were drawn on the basis of assessment criteria. Marked improvement in signs and symptoms in Patient’s condition were seen.
Wave Transformation Pattern in Submerged Breakwater Planning with 2D Wave Model at Mengening Beach, Badung Regency, Bali, Indonesia
Authors: Ayu Meia Damayanthi I Dewa , Agung Putu Eryani I Gusti , Yasa Bagiarta I Ketut
Published: October 2023

Mengening Beach is located in Badung Regency, Bali, Indonesia. The average erosion rate in Badung Regency is 1.96 m/year, so the right plan is a submerged breakwater to reduce wave energy coming to the beach, which causes erosion. This building artistically does not lessen the beauty of the beach and sea because it’s below the sea mean sea water level (MSL). Because the beach is a tourist area, it is essential to maintain the beauty of the beach. Two-dimensional wave modeling uses the CMS Wave model on SMS software version 10.1 with two modeling scenarios: before and after there is a submerged breakwater. The two-dimensional wave results show that the submerged breakwater plan can dampen waves in the building placement area, which was initially 1.3 m-1.4 m high to 0.9 m-1.3 m, so this submerged breakwater plan can reduce waves by 10%-40%. From this research, readers can learn how to plan a submerged breakwater and know the performance of the planned breakwater function at Mengening Beach.
A Bluetooth-Enabled Device for Real-Time Detection of Sitting, Standing, and Walking: Cross-Sectional Validation Study
Authors: Daryabeygi-Khotbehsara Reza , Rawstorn Jonathan C , Dunstan David W , Shariful Islam Sheikh Mohammed , Abdelrazek Mohamed , Kouzani Abbas Z , Thummala Poojith , McVicar Jenna , Maddison Ralph
Published: October 2023

Background

This study assesses the accuracy of a Bluetooth-enabled prototype activity tracker called the Sedentary behaviOR Detector (SORD) device in identifying sedentary, standing, and walking behaviors in a group of adult participants.

Objective

The primary objective of this study was to determine the criterion and convergent validity of SORD against direct observation and activPAL.

Methods

A total of 15 healthy adults wore SORD and activPAL devices on their thighs while engaging in activities (lying, reclining, sitting, standing, and walking). Direct observation was facilitated with cameras. Algorithms were developed using the Python programming language. The Bland-Altman method was used to assess the level of agreement.

Results

Overall, 1 model generated a low level of bias and high precision for SORD. In this model, accuracy, sensitivity, and specificity were all above 0.95 for detecting sitting, reclining, standing, and walking. Bland-Altman results showed that mean biases between SORD and direct observation were 0.3% for sitting and reclining (limits of agreement [LoA]=–0.3% to 0.9%), 1.19% for standing (LoA=–1.5% to 3.42%), and –4.71% for walking (LoA=–9.26% to –0.16%). The mean biases between SORD and activPAL were –3.45% for sitting and reclining (LoA=–11.59% to 4.68%), 7.45% for standing (LoA=–5.04% to 19.95%), and –5.40% for walking (LoA=–11.44% to 0.64%).

Conclusions

Results suggest that SORD is a valid device for detecting sitting, standing, and walking, which was demonstrated by excellent accuracy compared to direct observation. SORD offers promise for future inclusion in theory-based, real-time, and adaptive interventions to encourage physical activity and reduce sedentary behavior.
Joint Modeling of Social Determinants and Clinical Factors to Define Subphenotypes in Out-of-Hospital Cardiac Arrest Survival: Cluster Analysis
Authors: Abbott Ethan E , Oh Wonsuk , Dai Yang , Feuer Cole , Chan Lili , Carr Brendan G , Nadkarni Girish N
Published: October 2023

Background

Machine learning clustering offers an unbiased approach to better understand the interactions of complex social and clinical variables via integrative subphenotypes, an approach not studied in out-of-hospital cardiac arrest (OHCA).

Objective

We conducted a cluster analysis for a cohort of OHCA survivors to examine the association of clinical and social factors for mortality at 1 year.

Methods

We used a retrospective observational OHCA cohort identified from Medicare claims data, including area-level social determinants of health (SDOH) features and hospital-level data sets. We applied k-means clustering algorithms to identify subphenotypes of beneficiaries who had survived an OHCA and examined associations of outcomes by subphenotype.

Results

We identified 27,028 unique beneficiaries who survived to discharge after OHCA. We derived 4 distinct subphenotypes. Subphenotype 1 included a distribution of more urban, female, and Black beneficiaries with the least robust area-level SDOH measures and the highest 1-year mortality (2375/4417, 53.8%). Subphenotype 2 was characterized by a greater distribution of male, White beneficiaries and had the strongest zip code–level SDOH measures, with 1-year mortality at 49.9% (4577/9165). Subphenotype 3 had the highest rates of cardiac catheterization at 34.7% (1342/3866) and the greatest distribution with a driving distance to the index OHCA hospital from their primary residence >16.1 km at 85.4% (8179/9580); more were also discharged to a skilled nursing facility after index hospitalization. Subphenotype 4 had moderate median household income at US $51,659.50 (IQR US $41,295 to $67,081) and moderate to high median unemployment at 5.5% (IQR 4.2%-7.1%), with the lowest 1-year mortality (1207/3866, 31.2%). Joint modeling of these features demonstrated an increased hazard of death for subphenotypes 1 to 3 but not for subphenotype 4 when compared to reference.

Conclusions

We identified 4 distinct subphenotypes with differences in outcomes by clinical and area-level SDOH features for OHCA. Further work is needed to determine if individual or other SDOH domains are specifically tied to long-term survival after OHCA.
Peran Disregulasi Emosi terhadap Kecenderungan Melakukan Perilaku Nonsuicidal Self-Injury (NSSI) pada Remaja
Authors: Sabrina Vanda Azmi , Afiatin Tina
Published: October 2023

Nonsuicidal self-injury (NSSI) merupakan perilaku melukai diri sendiri secara sengaja tanpa ada niatan untuk bunuh diri. Terdapat berbagai macam faktor yang menjadi penyebab seseorang melakukan perilaku NSSI, salah satunya adalah disregulasi emosi. Namun, publikasi penelitian mengenai topik serupa di Indonesia masih sangat terbatas sehingga tujuan dari penelitian ini adalah mengetahui peran disregulasi emosi terhadap kecenderungan melakukan perilaku NSSI pada remaja. Partisipan (N=159) merupakan remaja berusia 14-24 tahun (laki-laki= 15, perempuan= 130, tidak menjawab= 14) yang pernah atau sedang melakukan perilaku NSSI. Data didapatkan dengan menyebarkan instrumen Inventory of Statement about Self-Injury (ISAS) dan Difficulties in Emotion Regulation Scale (DERS) yang sudah dimodifikasi. Hasil analisis menggunakan regresi linier sederhana menunjukkan bahwa disregulasi emosi berperan terhadap kecenderungan remaja melakukan perilaku NSSI dengan sumbangan efektif sebesar 26,1% (p<0,05).
Formulation Development and Cevaluation of Mucoadhesive Patch for Diabetes Using Plant Based Polysaccharide
Authors: S Tapade S. , Dappadwad Priyanka P. , Mane Priti M. , Suryawanshi Punam P. , Sangle Rameshwar , Lahade Ramraje , Tandle Rutuja , Bedre Rutuja
Published: October 2023

Abstract: Using plant-based polysaccharides, this study created a mucoadhesive patch for diabetes with the goal of delivering regulated medication release and improved therapeutic efficacy through sustained contact with the buccal mucosa. The patches' physicochemical characteristics, drug release kinetics, and mucoadhesive strength were examined after they had been made using the solvent casting procedure. . The created patch had exceptional mechanical, flexible, and physical qualities, as well as prolonged drug release and minimized burst release. Through in vitro cytotoxicity tests, the patch's biocompatibility was verified, demonstrating its suitability for buccal administration.the buccal region offcers and attractive route of administration for systemic drug delivery. The patches were prepared by solvent casting method the design of patches were evaluated for thickness, uniformity ,folding ,endurance ,weight uniformity ,swelling behavior,determination of mucoadhesive time. . To confirm the effectiveness and safety of this unique medication delivery method, additional in vivo research and clinical trials are required. If successful, these studies could pave the way for more individualized and efficient diabetic treatment options.
Hubungan self control dengan perilaku konsumtif belanja online pada mahasiswa rantau
Authors: Laura Putri Anggraini  , Hudaniah Hudaniah
Published: October 2023

Abstract. Technological advances have brought changes in various aspects of life, including shopping. Various online shopping sites appear and make it easier for someone to make a purchase If migrate students do online shopping, if it is not accompanied by good self-control, it can give rise to consumerist behavior. If online shopping activities carried out by overseas students are not balanced with good self-control, it will lead to consumptive behavior. The purpose of this study was to find out whether there is a correlation between self-control and consumptive behavior in online shopping among overseas students. This study used a correlational quantitative approach with 358 respondents as subjects. Sampling was carried out using a purposive sampling technique with the criteria are overseas students who are studying outside the city, aged 18-24 years, and routinely shop online at least once a month. The instruments used in this research are the self-control scale and the consumptive behavior scale. Data analysis in this study used Spearman’s rank correlation. The results showed that there was a negative relationship between self-control and online shopping consumptive behavior among overseas students because p=-0,521 and p=0,000 < 0,05 was obtained. This shows that the higher the self-control of overseas students, the lower the consumptive behavior and otherwise.
Keyword: Consumptive behavior, overseas student, self control
Perceptions of prospective biology teachers about collaboration in the prospective teacher training program
Authors: Sudrajat Ahmad Kamal , Ibrohim  , Herawati Susilo , Dita Purwinda Anggrella
Published: October 2023

Collaboration is an important skill for a teacher. Prospective teachers' perceptions about collaboration must be explored to discover their collaboration skills before becoming a teacher. This research aims to determine prospective biology teachers' perceptions regarding collaboration in their teacher preparation program. The study uses a mixed-method approach with an explanatory design. This research uses a survey instrument to obtain quantitative data and semi-structured interviews to obtain qualitative data. A total of 73 prospective biology teacher students were involved in this research. Data were analyzed using a mixed-method approach with explanatory design. The research results show that students have an expert level of collaboration. The gender factor does not significantly influence collaboration, but females have a higher overall score than males. Prospective biology teacher students have been able to define collaboration well, but their definition is not yet in-depth. Prospective biology teacher students have realized the importance of having collaboration skills to support their careers. The recommendation in this research is to develop an appropriate training model to train the collaboration skills of prospective biology teacher students.