bluuebunny/crossref_metadata_2025 huggingface dataset:
Robust asbestos-free brake pad from eucalyptus fiber reinforced polybenzoxazine composites
Authors: Bubphachart Pavarit , Tiptipakorn Sunan , Jubsilp Chanchira , Jongvisuttisun Passarin , Rimdusit Sarawut
Published: November 2022

This study explored the development of a robust asbestos-free brake pad composite material from benzoxazine resin, eucalyptus fibers and other constituents. Two different samples involving bleached and unbleached eucalyptus fibers reinforced polybenzoxazine composites were produced, denoted by BEFPC and UEFPC respectively. The effects of bleached and unbleached eucalyptus fibers reinforcement on the mechanical, thermal and tribological properties of the composite were investigated for the first time. The results obtained suggested that both the two composites possesses good flexural properties, great thermal stability, and high coefficient of friction (COF) at 5 wt% fiber reinforcement. The degradation temperature at 5% weight loss (Td5) for PBEC and PUBEC stood at 368 and 342 ℃ respectively, with both having residual weight of more than 68%. Storage modulus of 5.25 and 5.10 GPa, and glass transition temperature (Tg) of 219 and 237°C were recorded for the BEFPC and UEFPC respectively. Findings from the study of flexural strength of the BEFPC and UEFPC conducted reveals that the flexural strengths were as high as 54.5 and 51.3 MPa respectively. Furthermore, interesting results from the study on the tribology of the composites shows that the coefficient of friction (COF) is in the range of 0.2–0.7, and wear rates were lower than 3.5×10− 7 cm3/Nm as required by Thailand Industrial Standard (TIS: 97-2014). Therefore, this study presents eucalyptus fiber-reinforced polybenzoxazine brake pad composites (EFPBC) as a potential friction materials for the automobile industry.
WITHDRAWN: Global glycoproteomic analysis reveals specific glycation and glycosylation events associated with cognitive decline in older adults with type 2 diabetes
Authors: Tickotsky Nili , Morgenstern David , Wolf-Levy Hila , Cooper Itzik , Uribarri Jaime , Unger Ron , Buchman Aron S. , Levin Yishai , Beeri Michal Schnaider
Published: November 2022

INTRODUCTION: Molecular mechanisms underlying the well-known association between Type 2 diabetes (T2D) and late-life cognitive impairment are unknown. Alterations in glyco post-translational modifications (PTM) of serum proteins reflect altered cellular physiology and are associated with T2D and impaired cognition.
This novel large-scale mass spectrometry based glycoproteomics study aimed to identify therapeutic PTM targets that may link T2D with poor cognition.
METHODS: We performed LC-MS/MS–based novel glycoproteomic profiling of sera samples from 23 cognitively normal older adults with T2D. At baseline all people had normal cognition, but during 36-months, 8 participants developed cognitive impairment while 15 maintained normal cognition
RESULTS: We identified and quantified a total of 1,866 unique glycoproteoforms (i.e., peptides with a post-transcription sugar modification) that matched 201 annotated proteins. Group differences were observed for 72 glycoproteoforms at baseline. At the time of cognitive testing three years later, there were group differences for 137 glycoproteoforms. Group differences were observed for 14 glycoproteoforms both at baseline and at 3-year follow-up.
DISCUSSION: Glycoproteoforms may contribute to cognitive impairment in T2D, may identify adults with T2D at risk for cognitive impairment and are high value therapeutic targets for new therapies to mitigate the negative cognitive effects of T2D in old age.
CXCL2 participates in NDRG3-mediated colorectal cancer metastasis
Authors: Wu Huo , Hu Lei
Published: November 2022

Purpose: In our previous work, we showed that NDRG3 facilitated colorectal cancer (CRC) metastasis, yet the molecular mechanism underlying NDRG3-mediated CRC metastasis has not been elucidated. Thus, we explored the role of chemokine (C-X-C motif) ligand 2 (CXCL2) in NDRG3-mediated CRC metastasis.
Methods: Quantitative real-time polymerase chain reaction (qRT-PCR) and immunohistochemistry were used to detected the expression of CXCL2 in CRC. CXCL2 was modified in RKO/shNDRG3 and SW1116/NDRG3 cells. Wound healing assay, invasion assay and xenograft model were then introduced to determine the role of CXCL2 in NDRG3-mediated CRC metastasis. Western blotting analysis was used to investigate the potential mechanism of CXCL2 in CRC metastasis.
Results: CXCL2 was highly expressed in CRC tissue. CXCL2 contributed to the invasion of CRC cells, and acted as a downstream target of NDRG3. Knockdown of CXCL2 abolished the NDRG3-mediated invasive capacity of SW1116 cells, whereas the overexpression of CXCL2 enhanced the invasiveness of the RKO/shNDRG3 cells. Similar results were obtained in the xenograft model. Western blot result showed that CXCL2 knockdown inhibits Src activation in SW1116/NDRG3 cells.
Conclusion: CXCL2 serves as an oncogene in CRC and participates in NDRG3-mediated CRC metastasis.
A proposal of a unit of length for space in SI and English unit systems helps to imagine the universe
Authors: TAT Mustafa Ertunç
Published: November 2022

In this study, I propose two new units of length to regulate dimension perception in space: "space-meter" for metric and "space-yard" for the English unit system. The first unit proposal is based on the equatorial diameter of the Moon, the closest and biggest celestial body that is observable to the naked eye. The second one is referenced to the speed of light in a vacuum.
The first proposal includes that one space-meter equals a hundred times the Moon's equatorial diameter of 3475 km, equal to 347,500.0 km in the metric system. In the English unit system, it is assumed that a quarter of a space-inch equals the Moon's diameter of 2159 mil; one space-yard becomes 310,896 mils. The second proposal offers that one “space-meter” equals 299,792.458 km, and one “space-yard” equals 186,282.3971 mils; the distances a light beam can travel in a second in space. The second proposal will preserve the consistency from kilometer to mile or vice versa in space while preserving the perception of dimension.
Impact of Reciprocal Cross and Heterosis Phenomenon on Various Tomato Traits
Authors: Chawsh Shilan , Arkwazee Haidar Anwar
Published: November 2022

Reciprocal hybrids are achieved by crossing parental genotypes in both directions, while heterosis happens when the F1s surpass their parental lines for a characteristic. Two different tomatoes (Solanum lycopersicum L.) cultivars were crossed reciprocally to study the impact of the reciprocal cross and heterosis phenomenon on numerous tomato characteristics. Fifty-two different traits were measured, including flower, fruit, leaf, shoot, roots, yield and yield components, and physiochemical traits. The results showed that various traits were significantly influenced by reciprocal crosses, such as plant mass, petal length, cone length, pistil length, fruit width, fruit length, single fruit weight, fruit flesh weight, seed and placenta weight, number of fruits locules, fruit calyx weight, number of days to flower, total sugar, ascorbic acid, anthocyanin, and total phenolic content. In addition, the results showed that several traits showed positive high parent heterosis, which are the sepal length, pistil length, flower fresh weight, flower dry weight, flower moisture content, number of clusters per plant, number of flowers per plant, number of flowers per cluster, number of fruits per cluster, fruits number per plant, total fruits weight per plant, leaf length, leaf fresh weight, leaf dry weight, number of branches per plant, plant height, plant mass, ascorbic acid, total carotene, and anthocyanin. These results will be significantly helpful for the future breeding program, especially for breeding for yield and yield components that showed strong heterosis for most of the traits.
Neuroprotection by arbutin against haloperidol-induced Tardive Dyskinesia in rats and reducing neurotoxicity in SHSY-5Y cells
Authors: Singh Gursewak , Upadhayay Shubham , Navik Umashanker , Kumar Puneet
Published: November 2022

Background: Schizophrenia is a psychological condition, and its primary treatment is an antipsychotic medication. However, long-term use of typical antipsychotics often causes irregular involuntary movements, targeting the orofacial region. Due to its complex pathophysiology, there is no appropriate cure for Tardive Dyskinesia (TD). Arbutin, is a natural polyphenol, which is well known for neuroprotection. Therefore, this study evaluated the neuroprotective potential of arbutin against haloperidol induced neurotoxicity and orofacial dysfunction in TD rats.
Methods & results: SH-SY5Y cells were treated with 1 mM concentration of haloperidol and arbutin (5, 10, 15, and 20 µM) for 48 hours, arbutin significantly reduced haloperidol-induced neurotoxicity. Other side, Wistar rats were treated with haloperidol (1 mg/kg/for 21 days) for induced TD like symptoms and treatment with arbutin (50 and 100 mg/kg i.p.) for 21 days show significant decrease in vacuous chewing movements, tongue protrusions, and facial jerking and improved locomotor activity and motor coordination in haloperidol-treated rats. Further, arbutin treatment causes a significant reduction in nitric oxide, MDA, TNF-α, IL-β, and increases SOD, GSH and catalase levels in the striatum region in contrast to haloperidol-treated rats.
Conclusion: In-vitro and In-vivo experimental outcomes suggest that arbutin has the neuroprotective potential that limit TD progression. Their results indicate that arbutin has anti-inflammatory and antioxidant properties that strengthen motor activity and could be explored for cellular and molecular pathways for possible use in the treatment of TD.
PAFormer: Pyramid Attention Transformer for Polyp Segmentation
Authors: Huang Zhiyong , Xie Fang , Qing WenCheng , Wang MengYao , Liu Man , Sun Daming
Published: November 2022

Adenomatous polyps are usually the most common tumor in clinical screening for colorectal cancer. Early detection and removal of these precursor lesions have been proved to be effective in preventing many cancers and reducing the mortality rate. Therefore, intelligent polyp detection is an urgent matter, which could assist clinicians to quickly identify detected polyps at an early stage. This paper proposes a polyp segmentation method based on sequential self-attentive networks with the features such as the color and texture of images and the relationship features between them. The color and texture features of the region image are extracted and fused with the original image. The resulting feature maps are serially input to the Transformer model to learn high-level spatial and attentional features. The loss of spatial information is reduced by multiscale local aggregation. By aggregating the models from a global perspective, the transformer model can further reduce the loss of context information caused by deep convolution. Controlled experiments between the PAFormer network and the mainstream polyp segmentation networks are conducted on five datasets, including ColonDB, ETIS, CVC-ColonDB, CVC-612 and Kvasir. The results show that the segmentation accuracy of PAFormer has great improvement on the datasets and PAFormer is superior to existing mainstream baseline networks.
Predictors of long-term healing for endorectal advancement flap for anorectal fistulas
Authors: Muharrem Oner , Abbas Maher Aref
Published: November 2022

Background
Anorectal fistulas are some of the commonest surgical proctologic disorders treated by surgeons. Despite the recent introduction of various sphincter preserving techniques, the search for the optimal operation continues. The purpose of this study was to determine the predictors of long-term healing for the endorectal advancement flap
Methods
A retrospective review of a single surgeon experience with the endorectal advancement flap for anorectal fistulas over an 18-year period. The impact of various patient and fistula related factors were analyzed for their impact on the primary endpoint of long-term fistula healing
Results
87 patients underwent endorectal advancement flap (Male/Female 42.5/57.5%). Median age was 41 years. Sixty-nine patients (79.3%) had anal fistula while 18 patients had rectal fistula (20.7%). An anterior based fistula was noted in 45 patients (51.7%). The most common etiology was cryptoglandular disease (87.4%). The median operative time was 75 minutes (range 36–250). Postoperative septic complications were noted in 4 patients (4.6%). Fistula healing was documented in 80 patients (93%). During a median follow-up of 4 months (range 1–38, 1 patient lost to follow-up), recurrence was noted in 8 patients (9.3%), yielding an overall long-term success rate of 83.7%. The long-term healing rate was higher in patients with fistulas from cryptoglandular etiology (86.6%) compared to fistulas from other etiologies (63.6%) [p = 0.027].
Conclusions
The endorectal advancement is associated with a high healing rate, a low postoperative septic complication rate, and infrequent risk for recurrence. Long-term healing without recurrence is achieved more frequently in patients with cryptoglandular etiology of the fistula compared to patients with non-cryptoglandular etiology.
Eryngium bourgatii Extract Inhibits Iron Corrosion and Bacterial Growth in Fresh and Marine Water Media
Authors: Zaki Salma Hassan , Hassouna Mohammed Salah El-Din , Hefnawy Ahmed , Helmi Shacker
Published: November 2022

Bi-functional effect ofEryngium bourgatiiextract on inhibiting iron corrosion and bacterial growth in both fresh and marine water media was studied using weight loss measurements for corrosion inhibition and well diffusion method for bacterial growth inhibition. At 150 mg/100 mL inhibition efficiency of corrosion reached 95% and 91% in fresh and marine medium respectively. The results showed clearly thatE. bourgatiiethanol-hexane crude extract is strongly active in both media. Three quantitative methods were applied for measuring corrosion rate of iron metal cylinders: relative weight loss, iron released in the medium, and turbidity. Statistical analyses showed that the three methods are comparable and any method of the three could be used to measure corrosion rate. Experimental data obeyed Langmuir isotherm model. Optical and scanning electron microscopy (SEM) images revealed the smoothness and homogeneity of adsorption layer on the iron nail surface. Regarding bacterial growth inhibition at ratio of 150 mg/100 mL medium was found to be effective.
Phylogeny of transferable oxazolidinone resistance genes and homologs
Authors: Kardos G. , Laczkó L. , Kaszab E. , Timmer B. , Prépost E. , Bányai K.
Published: November 2022

This study aims at delving into the phylogenetic origin of transmissible oxazolidinones resistance mechanisms conferring cross-resistance to other drugs of human and veterinary importance. Amino acid sequences of the five cfr ribosome methylases, optrA and poxtA proteins were used as queries in search against 219549 bacterial genomes in the NCBI RefSeq database. Hits with > 40% amino acid identity and > 80% query coverage were aligned and phylogenetic trees were reconstructed. All five cfr genes produced very similar trees, with rlmN housekeeping ribosome methylases basal to sister groups of S-adenosyl-methionine dependent methyltransferases from Deltaproteobacteria and Actinomycetia, including antibiotic producer Streptomyces and of the monophyletic group of cfr proteins. Basal branches from the latter contained paenibacilli and other soil bacteria; then split to the clades [cfr(C):cfr(E)] and [[cfr:cfr(B)]:cfr(D)], always with various Bacillaceae in their stems. Lachnospiraceae were encountered in basal branches of both optrA and poxtA trees. The ultimate origin of cfr genes is rlmN housekeeping methylases, which evolved into a suicide-avoiding methylase in antibiotic producers; a soil organism (Lachnospiraceae, Paenibacilli) acted probably as agent of transfer into pathogens. In case of optrA, the porcine pathogenic Streptococcus suis was present in all branches, while closest to poxtA were proteins from Clostridia.
Cost effectiveness analysis of expanding tuberculosis preventive therapy to household contacts aged 5-14 years in the Philippines
Authors: Ilaiwy Ghassan , Keim-Malpass Jessica , Tuppal Romella , Ritua Alexander F. , Bassiag Flordeliza R. , Thomas Tania A.
Published: November 2022

Background: Children aged 5-14 years who are household contacts of index pulmonary TB cases have limited coverage for TB preventive therapy (TPT) due to variable uptake of the national guideline recommendations in the Philippines. We conducted a cost effectiveness analysis evaluating the expansion of latent TB testing and treatment among pediatric (5-14 years) household contacts of index TB patients in the Philippines.
Methods: Using a Markov state transition model, eligible household contacts (HHCs) age 5-14 years are screened for latent TB infection (LTBI) with either the tuberculin skin test (TST) or interferon gamma release assay (IGRA). Those who test positive are then simulated to receive one of the following TPT strategies: 6 months of daily isoniazid (6H), 3 months of weekly isoniazid and rifapentine (3HP), 3 months of daily isoniazid plus rifampicin (3HR) and the current practice of no testing or treatment for LTBI (NTT). The analysis assesses the projected cost and quality-adjusted life years (QALY) gained for every strategy from the perspective of the Philippines public healthcare system over a time horizon of 20 years. The total cost and gain in QALYs are presented as an incremental cost-effectiveness ratio (ICER) comparing cost per QALY gained for each strategy over NTT.
Results: Our model estimates that expanding TPT coverage to HHCs aged 5-14 years would be cost effective with incremental cost-effectiveness ratios (ICERs) ranging from 1,024 $/QALY gained when using TST and 6H (Uncertainty range: 497 - 2,334) to 2,293 $/QALY gained when IGRA and 3HR are used (Uncertainty range: 1,140 – 5,203). IGRA cost would have to drop to $5.50 to achieve similar results to strategies using TST. These findings were robust to sensitivity analyses over a wide range of parameter values.
Conclusion: Expanding TPT coverage to HHCs aged 5-14 years is cost effective when using TST and 6H closely followed by a strategy combining TST and 3HP. IGRA cost will require significant reduction to achieve results similar to TST.
Decimal to Excess-3 and Excess-3 to Decimal Code Converters in QCA Nanotechnology
Authors: Fouladinia Farhad , Gholami Mohammad
Published: November 2022

In this paper, two digital code converters are presented, excess-3 to decimal, and decimal to excess-3. The tile method is used to design proposed circuits in quantum-dot cellular automata (QCA) nanotechnology. The tile method gives a unique block for the majority and NOT gates. This property facilitates integrating circuits and since the NOT gate is not used in the tile method, the proposed circuits can do their work as fast as possible. Both of the proposed code converters has 1.75 clock cycles delay and have an energy dissipation of about 100meV. In the excess-3 code to decimal converter 516 cells are used, which occupy an area equal to 0.43µm2 also in the decimal to excess-3 code converter. 321 cells are used, which occupy an area equal to 0.28 µm2.
The effect of friction and wear behavior on the signal transmission of brush-ring system during electrical contact sliding
Authors: Yuan Youlu , Hu Tao , Song Lizhi , Lv Lei , Shuang Jiajun , Wu Haihua , Liu Jianyong , Zhang Yi
Published: November 2022

Copper-graphite brush and slip-ring systems are often used to transmit electrical energy and signal between moving and stationary parts. At present, the research on the brush-ring system mainly focuses on power transmission, while on signal transmission is relatively lesser. In this study, the effects of friction and wear behavior on signal waveform distortion were in-situ analyzed using a custom-designed tribotester, which can specially synchronize the slip-ring rotation period with the input signal waveform. Results were analyzed comprehensively from tribological and electrical aspects to find out the key factors, including friction coefficient, friction temperature, contact resistance, surface morphology, roughness, wear particles, and compositions. It was found that the distortion of signal waveform is mainly affected by the friction film. During the sliding electrical contact motion, the increase of friction film will increase the contact resistance, which in turn increases the signal waveform distortion. At the same time, under the normal load and shear force, the friction film moves along the sliding direction, hence causing the signal phase angle to shift. From a tribological point of view, the friction coefficient and temperature decrease with increasing the friction film. So, for the brush-ring system, the formation of friction film is good for the friction stability but bad for signal transmission.
Full title: Managing the fear of childbirth, developing a care program: a multi-method study
Authors: Bakhteh Azam , Jaberghaderi Nasrin , kolivand Mitra , Rezaei Mansour , Motaghi Zahra
Published: November 2022

Background: Despite the importance of fear of childbirth and the necessity of implementing appropriate care methods to increase women's willingness to childbearing and their more tendency to perform natural childbirth, there is no clear process in this field in the care programs of the country's health system. The present study was designed with the aim of developing a guideline for managing the fear of childbirth in the current context.
Methods: This is a multi-method study which was conducted in five stages within the framework of the National Institute for Health and Care Excellence (NICE) guideline. A research committee consisting of five focal and 16 secondary members was formed. The stages included determining the scope of the study, developing guideline (a qualitative study and a systematic review, triangulation of the data, and producing a preliminary draft), consultation stage (validation of the protocol Using nominal group method), as well as revision and publication stages.
Results: The clinical guideline of Managing the fear of childbirth with 190 evidence-based recommendations was developed in seven main areas, including the Pre-pregnancy period, pregnancy period, making childbirth more pleasant, training empowerment of employees, improving the service delivery system, social support and clinical guide evaluation methods.
Conclusions: We are hoping by applying this clinical guideline in maternal health care settings to move towards an integrated care plan for fear of child birth in the context of our health system. Health care organizations should support to form multi-specialty teams to care for mothers with fear of childbirth. Through holistic care, they can constantly examine the psychological needs of pregnant mothers, including the fear of childbirth, along with their other needs, and manage them correctly.
Machine Learning-based Ensemble Modeling for Mountain Hazards Susceptibility Assessment
Authors: Wang Zhijun , Chen Zhuofan , Ma Ke , Zhang Zuoxiong
Published: November 2022

In mountain hazard susceptibility mapping and assessment using machine learning models, the choice of model parameters is a significant factor in determining the accuracy of the model prediction. This work provides a novel method for developing a random forest (RF)-based prediction model by embedding hyperparametric optimization ensembles. The performance of the RF model is enhanced by employing a Bayesian optimization (Bayes) method and a Genetic algorithm (GA) and verified in the Wudu section of the Bailong River basin, China, a typical mountainous hazard-prone area. Fourteen influencing factors were selected in conjunction with field measurements to characterize the cascading ''collapse-landslide-debris flow'' hazard chains in the study area, and datasets for training (80%) and validation (20%) models were constructed for 378 hazard sites. Based on multicollinearity analysis and Relief-F two-step evaluation, typical statistical performance metrics such as the confusion matrix, recall, precision, accuracy, F1 and area under the operating characteristic curve (AUC) of individuals were used to evaluate model performance. Our results revealed that all the 3 models (i.e., RF, GA-RF, and Bayes-RF) performed well (AUC: 0.89 ~ 0.92), but the Bayes-RF model performed the best (AUC = 0.92), which can be used as a highly accurate and robust mountain hazard susceptibility assessment model applicable in the study area and other regions. Meanwhile, the generated susceptibility map can guide stakeholders in making appropriate mountain hazard prevention and control measurements in the region.
Multi-Channel 2D-CNN And Attention-Based BiLSTM Method for Sentiment Analysis on Low-Resource Ewe Language
Authors: Agbesi Victor Kwaku , Wenyu Chen , Ukwuoma Chiagoziem C. , Kuadey Noble A. , Browne Judith A. , Agyemang Isaac Osei
Published: November 2022

The unavailability of annotated dataset for a low-resource Ewe language makes it difficult to develop an automated system to appropriately evaluate public opinion on events, news, policies, and regulations in the language. In this study, we collected and preprocessed a low-resourced document-level Ewe sentiment dataset based on social media comments on five (5) different topics. Additionally, we generate three (3) word embedding models (Global vectors, word-to-vector and continuous bag-of-words ) for exploiting sentiment representation based on the dataset. We further proposed a novel multi-channel two-dimensional (2D) convolutional neural network fuse with attention-based-bidirectional long-short term memory (MC2D-CNN+BiLSTM-Attn) to detect the exact sentiment feature from the Ewe document. The proposed method can efficiently describe the following emotions: anger, annoyance, happiness, surprise, and, sadness from the newly developed dataset. Extensive experiments indicate that MC2D-CNN+BiLSTM-Attn method marginally outperformed other known state-of-the-art methods. Results show that in detecting the precise sentiments from raw Ewe textual context, the BiLSTM incorporating Glove outperforms word2vec and CBOW embedding with an accuracy of 0.72714. Furthermore, Attn+BiLSTM and Multi-channel CNN methods incorporating word2vec embedding layer perform better than Glove and CBOW embedding with an accuracy of 0.8483 and 0.8965 while our proposed technique with the same word2vec embedding recorded 0.9493.
Debridement, decompression and interbody fusion by using biportal spine endoscopy on patients diagnosed with lumbar spine tuberculosis: 1 year follow-up
Authors: Yu Yang , Xie Yizhou , Zhou Qun , Wang Yongtao , Feng Chengzhi , Fan Xiaohong
Published: November 2022

Objectives
The study is aimed to evaluate clinical outcomes of debridement, decompression and interbody fusion by using biportal spine endoscopy to treat patients diagnosed with lumbar spine tuberculosis (LST).
Methods
Forty patients diagnosed with LST who underwent debridement, decompression and interbody fusion by using biportal spine endoscopy between January 2020 to March 2021 were studied. The operation time, blood loss, complication rate, fusion rate, Visual Analog Scale (VAS), Oswetry disability index (ODI), Japanese Orthopedic Association (JOA), Erythrocyte Sedimentation Rate (ESR), C-reactive protein (CRP) and kyphotic Cobb’s angle were measured to explore the effects on LST patients.
Results
The patients were followed up for 12–16 months, with a mean of 14.6 months. The mean operation time was 223.4 ± 94.4 min (range, 140–410 min), together with 235.0 ± 190.5 cc of blood loss (range, 120–700 cc). From preoperation till last phase of follow-up, the mean preoperative VAS (5.86 ± 0.86) and ODI (74.29 ± 6.26) decreased significantly to 1.57 ± 0.65 and 8.29 ± 3.05, respectively. Additionally, the mean JOA increased from preoperative (10.29 ± 2.58) to (24.93 ± 1.86). Meanwhile, the mean preoperative ESR and CRP (74.36 ± 8.18 and 71.28 ± 8.58, respectively) decreased to average values. The preoperative kyphotic Cobb’s angle (21.40 ± 2.22 ) decreased to (9.86 ± 0.76 ) postoperatively. However, the kyphotic correction remained unchanged at the last phase of follow up. Furthermore, the fusion rate was identified to be 90%. Besides, the complication rate was 7.3% ( three cases of cerebrospinal fluid leakage).
Conclusion
Debridement, decompression and interbody fusion by using biportal spine endoscopy might be an ideal options to treat LST patients. More long term and multi-samples studies are needed to further verify the perspective.
Sodium butyrate ameliorates fluorosis-induced neurotoxicity by regulating hippocampal glycolysis in vivo
Authors: Li Yangjie , Wang Zhengdong , Li Jing , Yu Yang , Wang Yuan , Jin Xiaoxia , Dong Yun , Liu Qingsong , Duan Xiaoxu , Yan Nan
Published: November 2022

Fluorosis can induce neurotoxicity. Sodium butyrate (SB), a histone deacetylase inhibitor, has important research potential in correcting glucose metabolism disorders and is widely used in a variety of neurological diseases and metabolic diseases, but it is not yet known whether it plays a role in combating fluoride-induced neurotoxicity. This study aims to evaluate the effect of SB on fluoride neurotoxicity and the possible associated mechanisms. The results of HE staining and Morris water maze showed that in mice exposed to 100 mg/L fluoride for three months, the hippocampal cells arranged in loosely with large cell gaps and diminished in number. In addition, 1000 mg/kg/day SB treatment improved fluoride-induced neuronal cell damage and spatial learning memory impairment. Western blotting showed that the abundance of malate dehydrogenase 2 (MDH2) and pyruvate dehydrogenase (PDH) in the hippocampus of mice increased after fluorosis, while the abundance of pyruvate kinase M (PKM), lactate dehydrogenase (LDH) and hexokinase (HK) decreased. SB treatment reversed the decreased glycolysis in the hippocampus of fluorosis mice. We suspected that the PI3K/AKT/HIF-1α pathway may be involved in mediating the protective effects of SB against fluorosis invasion in the hippocampus. These results suggested that SB could ameliorate fluorosis-induced neurotoxicity, which might be linked with its function in regulating glycolysis as well as inhibition of the PI3K/AKT/HIF-1α pathway.
Prediction for Nonlinear Time Series by Improved Deep Echo State Network Based on Reservoir States Reconstruction
Authors: Yu Qiufeng , Zhao Hui , Li Li
Published: November 2022

Echo state networks (ESN) have received extensive attention because of their superior performance in nonlinear time series forecasting tasks. Most of the research on ESN focuses on extracting features from time series and improving the activation function to enhance prediction accuracy. In this study, we creatively propose recombining the obtained features to improve the prediction accuracy further. To this end, two state reconstruction methods are developed based on the existing features in the ESN. Additionally, ESN is very sensitive to the setting of hyperparameters, resulting in its unstable performance of time series prediction. Thus, we adopt the Self-Normalizing Activation (SNA) function to reduce the model’s sensitivity to hyperparameters and improve its stability. Then our proposed model is compared with the popular improved ESN models like DeepESN, GroupESN, and Grouped DeepESN on four time series datasets. The results show that our model has the best prediction performance.
Clinical practice guidelines for the pharmacological treatment of chronic asthma in a paediatric population – A Systematic Review Protocol
Authors: Addae-Kyereme Christine , Chandanani Mehak , Shah Aishwarya , Bantounou Maria Anna , Kumar Niraj , Turner Stephen
Published: November 2022

Background: Chronic asthma is one of the most common childhood conditions. However, discrepancies can be identified amongst treatment recommendations made by clinical practice guidelines for the management of this condition. As such, the proposed systematic review will aim to summarise and compare paediatric chronic asthma guideline recommendations, to promote the development of cohesive guidelines for the appropriate management of this patient cohort.
Methods: Our proposed systematic review will identify guidelines for chronic paediatric asthma management. The MEDLINE, Embase and Scopus databases were searched using synonyms of the following keywords: “asthma” AND “guidelines” AND “treatment” AND “pediatrics”.The quality of included studies will be assessed using the Appraisal of Guidelines, Research and Evaluation II (AGREE II) instrument. Narrative synthesis will be used to describe the quality and recommendations of the guidelines.
Discussion: The results of this systematic review will enhance clinical decision-making in the management of paediatric chronic asthma, and will additionally identify heterogeneity in guidelines internationally. These outcomes may minimise this heterogeneity and promote the development of an established common treatment matrix in future guidelines. Additionally, this systematic review will aid researchers in identifying gaps in knowledge and further avenues for clinical study. The results of this systematic review will be published in a peer-reviewed journal and presented at conferences.
Synthesis, characterization, and application of nanohybrid formed by mixing carboxylated cellulose nanocrystal and zinc nitrate hexahydrate by precipitation method using Oxytenanthera abyssinica as raw material
Authors: Worku Limenew Abate , Bachheti Rakesh Kumar , Tadesse Mesfin Getachew , Bachheti Archana
Published: November 2022

In this study, cellulose from Oxytenanthera abyssinica was hydrolyzed to create carboxylated cellulose nanocrystals in a solution of citric acid and sulfuric acid. Afterward, nanohybrids were synthesized using carboxylated cellulose nanocrystals, zinc nitrate hexahydrate for photocatalytic degradation, and antibacterial and antioxidant properties. The experimental results were characterized using FTIR, XRD, SEM, and UV-Vis spectroscopy. Data from SEM, XRD, DLS, and FTIR spectra showed that ZnO nanoparticles were loaded on carboxylated CNC to form a nanohybrid of CNC/ZnO with mean nanoparticles size of 164.18 nm and size distribution between 94–351 nm. The data showed CNC/ ZnO nanohybrid had higher antibacterial, photocatalytic and antioxidant activities than CNC. The higher antibacterial activity was observed against both grams positive (Klebsiella pneumonia and Escherichia coli) and gram-negative bacteria (Staphylococcus epidermidis and Staphylococcus aureus) with an inhibition zone of 26.00±1.00 to 41.33±1.15 mm in comparison with Ciprofloxacin. The maximal amount of methylene blue photodegradation (about 91.52%) was seen after 75 minutes of exposure to a UV lamp. 53.151.03% DPPH radical scavenging actives with IC50 value of 117.66 µm/ml were obtained at 125 µm/ml concentration of CNC/ZnO sample. Biomedical and environmental applications of cellulose are limited by its extremely low antibacterial, photocatalytic, and antioxidant properties. Therefore, this study was done to enhance these properties by synthesizing a nanohybrid of cellulose nanocrystals from cellulose produced from Oxytenanthera abyssinica and ZnO inorganic salt.
A BRAT1 synonymous mutation affecting exon splicing leads to lethal neonatal rigidity and multifocal seizure syndrome: A Chinese case report.
Authors: Luo Zhihua
Published: November 2022

Rigidity and Multifocal Seizure Syndrome, Lethal Neonatal (RMFSL, OMIM#614498), is caused by mutations of the BRAT1 gene. Our patient had the typical syndromes of RMFSL, and Trio whole exome sequencing (trio-WES) identified a homozygous synonymous variant (BRAT1:C.1395(exon10)G > C). Given that the pathogenicity of synonymous mutation (p.Thr465Thr) is most likely underestimated, a further transcriptional study of the father showed that C.1395(exon10)G > C mutation would result in abnormal splicing, which caused the exon 10 skipping and affected protein features. We first confirmed the pathogenicity of the synonymous mutation of BRAT1 using a transcriptional study.
Evaluation of 25-hydroxyvitamin D (25(OH)D) levels before and during the COVID-19 pandemic: a cross-sectional study and trend analysis involving 86,772 samples
Authors: Arayici Mehmet Emin , Uysal Sila Ovgu Korkut , Leblebici Asim , Akcali Zeynep , Edizer Deniz Tuna , Kabul Seher , Cimrin Dilek , Ellidokuz Ender Berat
Published: November 2022

Purpose
The aim of this paper was to evaluate the change in 25-hidroxyvitamin D (25(OH)D) levels before and during the COVID-19 pandemic.
Methods
In this retrospective, cross-sectional and methodological study included 86,772 patients (18–75 years) samples who were admitted to the University Hospital for various reasons and whose 25(OH)D levels were measured in the biochemistry unit between 2019–2020 and 2020–2021 (before and during the COVID-19 outbreak). A time series analysis of monthly averages for 25(OH)D was performed. For the purpose of seasonal study, the mean levels of 25(OH)D are grouped by years. Data were modeled in terms of 25(OH)D levels using the MATLAB Curve Fitting Toolbox.
Results
There was no significant difference between the sexes according to 25(OH)D levels (p > .05). 25(OH)D levels were significantly higher in the summer months and lower in the winter months (p < .001). When comparing the spring months, 25(OH)D levels in 2020 were found to be significantly lower than in 2019 (p < .001); on the contrary, when examined based on the summer, autumn, and winter months, 25(OH)D levels increased in 2020 compared to 2019 (p < .001). In the estimates curve obtained with an error margin of 11% in the time series analysis, it was estimated that the 25(OH)D averages after the pandemic would be similar to those before the pandemic.
Conclusion
Restrictions, partial or complete closures, and curfews can significantly affect individuals' 25(OH)D levels during the COVID-19 outbreak. Evidence-based public health policies regarding vitamin D, especially during pandemic and closure periods, have critical importance.
The level of headache disability among different population samples in Kuwait and its relationship to cognitive distortions
Authors: Haggag Abdelmotaleb Abdelkader
Published: November 2022

Headache disorder is spreading at a high rate all over the world. And it is not only painful, but also disabling. Headache disorders impose a significant burden on patients including significant personal suffering, deterioration in quality of life, financial cost, and damage to family life, social life and employment. This research aimed to know the level of headache disability among different population samples in Kuwait and its relationship to cognitive distortions. An Internet-based cross-sectional study was conducted where the participants from different population samples in Kuwait were targeted using total population sampling. 450 participants from Kuwaiti society were recruited, between September4 and October28, 2022. Participants completed two self-reported scales. The scales included The Henry Ford Hospital headache disability inventory (HDI):and The Cognitive Distortions Questionnaire (CD-Quest). The results reveal that there is low level of headache disability among participants. There were differences between participants with high headache disability and participants with low headache disability in the total score of CD-Quest and its dimensions. There was a positive correlation between headache disability and the total score of CD-Quest and most of its dimensions. The groups most suffering from headache disability were: high -income peoples, residents, participants aged 25-40 years, females, marrieds, patients with chronic diseases, participants with post-graduate qualifications.
COVID-19 related changes in eating disorder pathology, emotional and binge eating and need for care: a systematic review with frequentist and Bayesian meta-analyses
Authors: Molendijk Marc , Guzel Âmine , Mutlu Naz Lâl
Published: November 2022

Objective
The COVID-19 pandemic has been a leading cause of stress and feelings of loss of control, both of which have been related to Eating Disorder (ED) pathology onset and symptom deterioration. To estimate the magnitude of changes in the prevalence rates of, and indicators for, ED psychopathology in the face of the COVID-19 pandemic.
Method
Pre-registered systematic review with frequentist and Bayesian meta-analyses. Searches for eligible studies were performed in PubMed, Web of Science and pre-print servers until March 18 2022.
Results
Our searches yielded 39 eligible studies on a total of 4.639.947 subjects. Rates of diagnosed and self-reported ED’s and ED symptoms significantly increased in the face of the pandemic. ED symptoms and severity, and emotional and binge eating were reported more often during the pandemic. The need for ED related care increased concordantly. The strength of significant associations was small-to-moderate in most cases. Findings of frequentist and Bayesian meta-analysis converged. Moderators of the substantial between-study heterogeneity were not detected and there was little evidence for the existence of publication bias.
Conclusions
Altogether, our results suggest that the COVID-19 pandemic is associated with a wide spread negative effect on ED pathology. The development of online prevention and intervention programs for EDs during stressful times like a pandemic is encouraged. A limitation is that results may be prone to biases, amongst others, self-report bias.
Preregistration
Prospero [https://www.crd.york.ac.uk/prospero] ID: CRD42022316105
Evaluating the efficacy of human dental pulp stem cells and scaffold combination for bone regeneration in animal models: A systematic review and meta-analysis
Authors: Namjoynik Amin , Islam Md Asiful , Islam Mohammad
Published: November 2022

Introduction:
Human adult dental pulp stem cells (hDPSC) and stem cells from human exfoliated deciduous teeth (SHED) hold promise in bone regeneration for their easy accessibility, high proliferation rate, self-renewal and osteogenic differentiation capacity. Various organic and inorganic scaffold materials were pre-seeded with human dental pulp stem cells in animals with promising outcomes in new bone formation. Yet, the clinical trial for bone regeneration using dental pulp stem cells is still in infancy. Thus, the aim of this systematic review and meta-analysis is to synthesise the evidence of the efficacy of human dental pulp stem cells and the scaffold combination for bone regeneration in animal bone defect models.
Methodology:
This study was registered in PROSPERO (CRD2021274976) and PRISMA guideline was followed to include the relevant full-text papers using exclusion and inclusion criteria. Data were extracted for the systematic review. Quality assessment and the risk of bias of the included papers were also carried out using CAMARADES tool. Quantitative bone regeneration data of the experimental (Scaffold + hDPSC/SHED) and the control (Scaffold only) groups were also extracted for meta-analysis.
Results
49 papers were included for systematic review and only 27 of them were qualified for meta-analysis. 90% of the included papers were assessed as medium to low risk. In the meta-analysis, qualified studies were grouped by the unit of bone regeneration measurement. Overall, bone regeneration was significantly higher (p < 0.0001) in experimental group (scaffold + hDPSC/SHED) compared to the control group (scaffold only) (SMD: 1.863, 95% CI: 1.121–2.605). However, the effect is almost entirely driven by the % bone formation group (SMD: 3.929, 95% CI: 2.612–5.246) while % BV/TV (SMD: 2.693, 95% CI: -0.001-5.388) shows a marginal effect and both bone mineral density (mg/cm3) and new bone formation (mm2) showed no effects. The funnel plot exhibits no obvious asymmetry representing a lack of remarkable publication bias. Sensitivity analysis also indicated that the results generated in this meta-analysis are robust and reliable.
Conclusion
This is the first synthesised evidence that showed that irrespective of the types or composition of the scaffolds, DPSCs/SHED and scaffold combination enhanced bone regeneration highly significantly compared to the cell-free scaffold. So, dental pulp stem cells would be a promising tool for treating various bone diseases, and more clinical trials need to be conducted to evaluate the effectiveness of dental pulp stem cell-based therapies.
STRATEGI MARKETING WISATA SYARIAH MELALUI INSTAGRAM
Authors: Amalina Danish Nur , Anwar Mashudi , Rachmawati Galuh
Published: November 2022

Tourism Marketing Strategy Through Instagram (Case Study of Blitar Chocolate Village). This type of research uses primary data and secondary data using qualitative research. The number of informants in this study amounted to 13 people (managers, employees, parking attendants, traders and visitors). Data collection techniques were carried out by means of interviews (interviews), and observations (observations), directly from respondents who were selected as samples. Based on the results obtained using qualitative analysis, it can be concluded in this study that the reasons why currently switching ways from conventional methods to Instagram marketing are, firstly because of technological advances, consumers are more inclined to use Instagram social media, secondly by using social media marketing in particular. Instagram can reduce prices in marketing financing, thirdly by utilizing influencers to further improve marketing on Instagram, and have a positive impact on the progress of Chocolate Village, lastly, the role of the variable place in the marketing mix can make visitors come back to Chocolate Village because Chocolate Village provides and presents an attractive place atmosphere for consumers and the price is also in accordance with the consumer's pocket. With advances in technology and promotional strategies can immediately move the hearts of consumers.
MANAJEMEN BISNIS : TINJAUAN ATAS PERLAKUAN AKUNTANSI ASET BIOLOGIS BERDASARKAN PSAK NO.69
Authors: Shalichah Nur’i Hidayatus
Published: November 2022

The accounting treatment of agricultural businesses should be in accordance with the reference to PSAK No. 69 on accounting for biological assets in agriculture. This paper aims to analyze comparatively PSAK No. 69 on UD. Barokah and UD. Makmur regarding the accounting treatment of biological assets using a qualitative approach and the type of case study. The results of the study are 1. The similarities between the two research objects are a) Standard financial reports for broilers by recording financial reports periodically every harvest (35 days). Biological assets come from outsiders by buying biological assets for maintenance and then selling them. Biological assets are measured by how much DOC yields and minus maintenance costs. The financial statements disclose the gains and losses for the current period. b). Broiler financial report standard UD. Barokah and UD. prosperous in accordance with PSAK 69, namely the statement of fixed assets is always recorded in each accounting period. Biological assets come from breeds not purchases. Agricultural assets are recognized by purchase or from crossbreeds from past events. Biological assets are measured at initial recognition and at the end of each reporting period at fair value less costs to sell. The presentation of biological assets in the financial statements is grouped under non-current assets. 2. Analysis of differences in recording biological assets of broiler chicken farms UD. Barokah and UD. Prosperity lies in the placement of the account. Financial reporting standards used by UD. Barokah is still simple and there are financial reports that have not applied applicable accounting standards. UD. Barokah does not record biological assets that have been classified in PSAK No. 69 (paragraph 43). The implication of this research is that the skill of recording financial statements is improved, in accordance with PSAK No. 69).