bluuebunny/crossref_metadata_2025 huggingface dataset:
Influence of an Alternative Diagnosis on the Diagnosis of Pulmonary Thromboembolism
Authors: del Villar Carrero Rafael Suárez , Martínez-Urbistondo Diego , de Asua Miguel De la Serna Real , Mazarro Alberto Cano , Fernández María Agud , Cobo Ana Rodriguez , Fernández Paula Villares
Published: October 2024

Background: The diagnosis of Pulmonary Embolism (PE) is based on the application of a priori probability scales such as the Wells scale or PERC criteria. However, the clinical heterogeneity of this pathology results in the absence of a target population to apply these algorithms. Moreover, these scales do not consider the possible influence of the presence of an objective alternative diagnosis to PE, complicating its clinical assessment and possibly leading to an increase in unnecessary testing or missed diagnoses.
Objective: The aim of this study is to evaluate the discrimination capacity of clinical objective factors with a high negative predictive value for PE, compared to PERC in terms of reducing unnecessary testing across different risk strata of the Wells scale.
Materials and Methods: This was a single-center retrospective cohort study, including patients who underwent chest CT angiography to rule out PE at a University Hospital between 2008 and 2017, considering the presence of PE as the study outcome. The study collected demographic data, comorbidities, and clinical presentation data. The presence of objective criteria for pneumonia, heart failure, exacerbation of COPD, or the use of anticoagulation in non-oncological patients was considered a priori criteria with a high negative predictive value.
Results: The analyses were performed on a cohort of 399 patients with an average age of 65 years and 53% females. A total of 139 patients were diagnosed with PE by CT angiography. The presence of factors with a high NPV showed a sensitivity and NPV of 100% in low-risk patients according to Wells, with sensitivity dropping below 50% in other populations. The association of these factors in the PERC plus criteria would allow a reduction of up to 34% in CT angiographies in patients with low risk according to the Wells scale.
Conclusions: The combination of risk stratification of the Wells scale and PERC plus criteria allows an absolute reduction of 34.3% in the performance of CT angiographies in patients classified as low risk with a sensitivity and a negative predictive value of 100%. The preexistence of an alternative diagnosis does not allow ruling out PE in patients with intermediate or high risk according to the Wells scale.
Topological Reinforcement Adaptive Algorithm (TOREADA) Application to Alerting of Convulsive Seizures and Validation with Monte-Carlo Numerical Simulations
Authors: Kalitzin Stiliyan
Published: October 2024

Detection of adverse events, for example convulsive epileptic seizures, can be critical for the patients suffering from variety of pathological syndromes. Algorithms using remote sensing modalities, such as video camera input, can be effective for real-time alerting but the broad variability of environments and numerous non-stationary factors may limit their precision. In this work, we address the issue of adaptive reinforcement that can provide flexible application of the alerting devices. The generic concept of our approach is the topological reinforced adaptive algorithm (TOREADA. Three essential steps, embedding, assessment and envelope act iteratively during the operation of the system, providing thus a continuous, on the fly reinforced learning. We apply this concept on the case of detecting convulsive epileptic seizures where three parameters define the decision manifold. Monte-Carlo type simulations validate the effectiveness and robustness of the approach. We show that the adaptive procedure finds the correct detection parameters, providing optimal accuracy, from a large variety of initial states. With respect to the separation quality between simulated seizure and normal epochs, the detection reinforcement algorithm is robust within broad margins of signal generation scenarios. We conclude that our technique is applicable to a large variety of event-detection systems.
How Supervisors Managed Their OHS Roles with Workers Working from Home During the COVID Epidemic: A Qualitative Study
Authors: Tenkate Thomas , Kramer Desre M , Peter Strahlendorf Peter , Holness D Linn
Published: October 2024

During the Covid-19 pandemic, although the experience of workers and managers was examined, the role, experiences and functions of supervisors was relatively underexplored, with no investigation into their changing health and safety responsibilities. This project attempted to fill this gap. Twenty supervisors across Canada were interviewed for an hour. A Framework Method guided the study. We used a conceptual framework of 10 supervisor functions to help direct the data collection, identify codes, manage and organize the data analysis, and identify major themes which were highlighted in the findings. What was found was that since supervisors did not have access to workers’ homes, they could not execute most of their OHS functions. They were obliged to give workers more control over how and when they worked. They Increased their communications with their workers in response to workers’ psychological health concerns. Notably, supervisors reported that they were under extreme stress. A hybrid work environment, with workers sometimes working at home, has become the new norm. Supervisor stress will continue to escalate unless upper management provides more support, supervisors get training on how to deal with the psychological health and safety of workers, and supervisors’ responsibilities are re-defined for at-home workers.
Identification of Transcriptional Regulators of Immune Evasion across Cancers: An Alternative Immunotherapeutic Strategy for Cholangiocarcinoma
Authors: Venkatraman Simran , Balasubramanian Brinda , Kongpracha Pornpan , Yangngam Supaporn , Chuangchot Nisa , Khanaruksombat Suparada , Thongchot Suyanee , Suntiparpluacha Monthira , Myint Kyaw Zwar , Soodvilai Sunphahas , Janvilisri Tavan , Jirawatanotai Siwanon , Thuwajit Chanitra , Meller Jarek , Chutipongtanate Somchai , Tohtong Rutaiwan
Published: October 2024

Background: Immune evasion in cancer is a multifaceted process that synchronizes pro-tumoral immune infiltration, immunosuppressive inflammation, and inhibitory immune checkpoint expression (IC). Recent developments have immunotherapies such as immune checkpoint blockade (ICB) and chimeric antigen receptor T-cell (CAR-T) therapy effectively impede this process but benefit a limited patient cohort. This investigation introduces a systemic immunotherapeutic strategy by inhibition of master-regulators of immune evasion (MR-IE). Methods: We utilized the TCGA PanCancer Atlas transcriptomic data to subset and stratify cancer samples based on IC expression levels and CIBERSORT to estimate immune cell infiltration. Differential gene expression analysis was conducted to unravel pathways associated with the immune evasion. Transcription Factor Enrichment Analysis and Survival Analysis was conducted to identify and rank candidate MR-IE per cancer type. The top-ranking candidate MR-IE of cholangiocarcinoma (CCA) was validated for its regulation of ICs using quantitative PCR and western blots. Orbitrap Proteomics was employed to assess changes in the immune-related proteome of CCA cells after MR-IE is inhibited or knocked-down. Lastly, CCA cell viability and immune-mediated cell death was assessed after MR-IE inhibition in combination with fourth-generation anti-folate receptor alpha (FRɑ) CAR-T cell therapy. Results: This workflow ranked and identified candidate MR-IE for 33 tumor types. MYC was identified as the high-ranking candidate MR-IE for CCA. MYC modulated PD-L1 expression adn key markers of inflammation and IC expression in CCA cells. Moreover, MYC inhibition was able to potentiate CAR-T mediated cell death in CCA cells. Conclusions: Cumulatively, these results offer a candidate list of MR-IE immunotherapeutic targets per cancer type that can be further explored and validated. This study also highlights the promise of MR-IE inhibition as a novel potent immunotherapeutic strategy for the treatment of CCA.
Consumer Understanding and Perceptions of Front-of-Pack Nutrition Labelling of Foods and Non-Alcoholic Beverages in Kenya; a Qualitative Study
Authors: Kirui Caliph , Asiki Gershim , Ojiambo Veronica , Karugu Caroline H , Mohamed Shukri F
Published: October 2024

Background: Front-of-package labelling (FoPL) is shown to be effective in assisting consumers make healthier food choices. Several countries are implementing various types of FoPL systems.
Objective: This study explored consumers’ perceptions and understanding of three different FoPLs and their insights into features that could influence the effectiveness of the symbols in Kenya
Methods: A qualitative study was conducted in four Counties in Kenya; Nairobi, Mombasa, Garissa, and Kisumu. Data was collected through twelve focus group discussions with 137 adults drawn from diverse socio-demographic and socio-economic backgrounds. Three FoPLs were assessed: Red and Green (RG) Octagon, Red and Green Octagon with icons and text (RGI), and the Black Octagon Warning label (WL). The FGDs explored participants’ perceptions of the symbols’ visibility and memorability, their understanding, potential effectiveness, and cultural appropriateness. Printed images displaying four different commonly consumed products bearing specific FoPLs were used during data collection. Data was analyzed thematically and organized using NVivo version 14.0.
Results: Results showed that Kenyan consumers had varied perceptions about the proposed FoPL symbols. Majority of the participants found the black Octagon WL to be most visible and memorable due to its good blend of black and white colours. Although the RG octagon symbol and RGI octagon symbols were also found to be eye-catching due to their bright colours, it emerged that the different colours often confused some participants on their meaning. Most participants understood the WL compared to the RG and RGI because they found the additional text more educative. Generally, the WL was preferred as the symbol most likely to influence consumer purchase behaviours and food consumption. All the three FoPLs tested were found to be culturally appropriate.
Conclusions: The Black Octagon Warning Label is the most easily visible and understood among the three FoPLs tested and has the potential to influence purchase and consumption behaviours among Kenyan consumers. Although the RG and RGI symbols are visually appealing to many, confusion related to different colours could affect their effectiveness. Consumers need to be educated on the use of FoPLs to ensure they discourage the purchase and consumption of unhealthy foods.
Modification and Validation of the System Causability Scale Using AI-Based Therapeutic Recommendations for Urological Cancer Patients: A Basis for the Development of a Prospective Comparative Study
Authors: Rinderknecht Emily , Winning Dominik von , Kravchuk Anton , Schäfer Christof , Schnabel Marco J. , Siepmann Stephan , Mayr Roman , Grassinger Jochen , Goßler Christopher , Pöhl Fabian , Siska Peter J. , Zeman Florian , Breyer Johannes , Schmelzer Anna Magdalena , Gilfrich Christian , Brookman-May Sabine. D. , Burger Maximilian , Haas Maximilian , May Matthias
Published: October 2024

The integration of artificial intelligence, particularly Large Language Models (LLMs), has the potential to significantly enhance therapeutic decision-making in clinical oncology. Initial studies across various disciplines have demonstrated that LLM based treatment recommendations can rival those of multidisciplinary tumor boards (MTBs); however, such data are currently lacking for urological cancers. This study provides the methodological foundation for the prospective CONCORDIA trial, which will generate this data for the first time. In this preliminary work, we evaluated the proposed measurement tool for the CONCORDIA study -the System-Causability-Scale (SCS) and its modified version (mSCS) - based on recommendations from ChatGPT-4 and an MTB for 40 urological cancer-scenarios. Both scales demonstrated strong validity, reliability (all aggregated Cohen’s K > 0.74), and internal consistency (all Cronbach’s Alpha > 0.9), with the mSCS showing superior reliability, internal consistency, and clinical applicability (p<0.01). Two Delphi processes were used to define the LLMs to be tested in the CONCORDIA study (ChatGPT-4 and Claude 3.5 Sonnet) and to establish the acceptable non-inferiority margin for LLM recommendations compared to MTB recommendations. The forthcoming ethics-approved and registered CONCORDIA non-inferiority trial will require 110 urological cancer scenarios, with an mSCS difference threshold of 0.15, a Bonferroni corrected alpha of 0.025, and a beta of 0.1. Blinded mSCS assessments of MTB recommendations will then be compared to those of the LLMs. In summary, this work establishes the necessary prerequisites prior to initiating the CONCORDIA study and validates a modified score with high applicability and reliability for this and future trials.
The Number of Health-Promoting Substances That All Edible Vascular Plants Contain Compared to the Total Number of Health-Promoting Substances of Five Wild Edible Plants (WEPs)
Authors: Åhlberg Mauri
Published: October 2024

In Åhlberg (2021, 2022b), I presented evidence for 57 health-promoting substances that all green vascular WEPs contain. I continued searching for health-promoting substances in the plant cells' basic structures and processes. While reading research reports of five invasive species, I found eight more health-promoting substances all green vascular wild edible plants have. This article adds eight new substances to the earlier 57, bringing the total to 65. This is a novel finding for which I provide research evidence. I present the latest research on five invasive wild edible plants (WEPs) species. Each contains at least the same 65 health-promoting substances and a varying number of species-specific health-promoting substances. Each WEP has 1) shared health-promoting substances that all green vascular plants have and 2) species-specific health-promoting substances. I also present how many of these substances prevent Alzheimer’s disease, according to experimental research.
An Approach to Studying Emotional Responses to Sustainability Materials Taking Natural Wood and Artificial Boards as Examples
Authors: Tan Shenghua , Gao Pin
Published: October 2024

Natural wood is generally perceived as expensive, while wood-based boards are cheap, but re-search has yet to explain definitively why these two materials receive such disparate evaluations. This study aimed to uncover the reasons behind this phenomenon by proposing an emo-tion-driven approach to material research. We collected 10 types of natural wood and artificial boards as experimental samples and tested 20 subjects' subjective evaluation of the samples and physiological indicators (electroencephalography and electrodermal activity). Through data analysis, we identified the relationships between the subjective and physiological data and the impact of material composition on these data. Specifically, we observed significant correlations between subjective and physiological data; however, no correlation was found between subjective and physiological valence. We also discovered that the components of materials significantly influence participants' subjective and physiological emotions. For example, materials with a rough texture elicited higher positive affectivity than those with a smooth texture, materials with coarse and mixed textures elicited higher positive affectivity than those with fine textures, and the brighter materials evoke more positive emotions in participants. This study revealed how material components influence participants' emotions and, more importantly, analyzed the processing techniques behind these components, providing a theoretical basis for the future development of high-value-added products made from wood-based boards.
El comandante de Janos protesta ante una fuerza armada de Sonora que entró a Chihuahua persiguiendo a los apaches (1844)
Authors: Orozco Víctor
Published: October 2024

Fragmento: Ahora que serán las 5 de la tarde acabo de tener noticia que Usted, con fuerza de 100 hombres del Departamento de Sonora, se ha introducido violentamente y, pasando por el Rancho de Pacheco distante de aquí cosa de dos leguas, se dirigió al presidio que está a igual distancia tomando prisionero al indio Negúle que con mi consentimiento se hallaba allí viviendo con su familia la que ha quedado dispersa.
Migrantes centroamericanos “atrapados” en Ciudad Juárez
Authors: Delgado Hernández Karla Iroazem
Published: October 2024

En el caso de la frontera de México con Estados Unidos, diferentes hechos ocurridos en ambos países a partir del siglo XXI, principalmente los ataques terroristas a las torres gemelas en Nueva York en 2001 y posteriormente la guerra contra el narcotráfico en México durante el gobierno de Felipe Calderón (2006-2012), propiciaron que las leyes que regulan el tránsito de personas al interior de Estados Unidos incorporaran mayores restricciones y enfocarlas como una carga no solamente política y económica, sino social y cultural.
Toma de decisiones y participación ciudadana
Authors: Guevara Camargo David
Published: October 2024

El propósito de este trabajo es examinar el camino que lleva a la decisión de una política pública y resaltar la necesidad de la participación ciudadana en la toma de decisiones gubernamentales. Se analiza el proceso por el que se tomó la decisión de asignar un predio para el esparcimiento en una zona habitacional ubicada al suroriente de la ciudad, de manera concreta se trata de construir una arena de rodeo donde se practique ese deporte y sea un atractivo turístico que desarrolle la economía del sector.
Camino de fierro
Authors: Orozco Víctor
Published: October 2024

La historia de los ferrocarriles se remonta a los comienzos de la revolución industrial en Inglaterra, durante la década de 1820-30, donde se empezaron a construir las primeras locomotoras de vapor y los trenes arrastrados por ellas. En unas cuantas décadas el novísimo medio de transporte se extendió por el mundo y se convirtió en el primer signo de la modernidad, que distinguía a los países ricos de los pobres. Tantas millas o tantos kilómetros de vías férreas tienes, tanto vales en el universo de la civilización, parecía ser la divisa del siglo XIX.
La poesía de Karen Cano como denuncia feminista
Authors: Armendariz Puentes Jorge Arturo
Published: October 2024

En este trabajo se analizan algunos de los poemas del poemario Cuna de Arena, de Karen Cano. Esta obra se centra en denunciar la violencia de género, el machismo, los feminicidios y otros temas de esa índole en Ciudad Juárez; el trabajo busca descubrir cómo la autora se vale de la poesía y de sus distintos recursos para realizar una denuncia efectiva, a la vez que poética.
La tríplice deshumanizante: fronteras, migración y marginación
Authors: Tena Muñoz Luis Manuel , Payán Alvarado Luis Antonio
Published: October 2024

Este breve texto se enfoca en esta compleja intersección manifiesta en la persona del migrante: La cambiante naturaleza de las fronteras en el siglo XXI, la migración y la identidad del sujeto ambulante, y la negación de la derechohabiencia a quienes por su itinerancia portan las fronteras en su cuerpo. El resultado, se hipotetiza, es una estructura deshumanizante, en la cual surge una estructura de castas—en la cual la sociedad se organiza en círculos concéntricos, con los migrantes situados en los márgenes de esta estructura social.
¿Un Museo en el Valle de Juárez?
Authors: Herrera Peña Alan Hernani
Published: October 2024

¿Un Museo en el Valle? Esa generalmente es la pregunta cuando se enteran de la existencia del Museo Regional del Valle de Juárez. Un proyecto que cumplió en abril de 2022 cuarenta años de haber sido impulsado por un joven profesor rural y su comunidad. Este profesor, de nombre Manuel Robles, impulsó otros proyectos alrededor del Museo, como lo es una clínica, un preescolar, guardería y una biblioteca. Así se plantea relatar la historia que llevó al profesor a desarrollar toda una visión de desarrollo social en los poblados a lo largo de la carretera Juárez- Porvenir. Asimismo, se plantea el presente y futuro del proyecto con respecto a las nuevas generaciones.
Los feminicidios en Ciudad Juárez
Authors: González Parada Ameyalli
Published: October 2024

La violencia de género es un tema delicado para México, pues desde hace tres décadas se ha posicionado como uno de los países con un mayor número de condenas en relación de violencia contra las mujeres. La creciente influencia de los grupos del crimen organizado no ha hecho más que recrudecer la violencia que viven las mujeres en el día a día en la región de la frontera norte del país, que se ha posicionado como un territorio clave para estos grupos.
ON THE MODELING OF BOUNDARY CONDITIONS IN THE PROBLEM OF DETERMINING THE NATURAL FREQUENCIES OF A PIPE
Authors: Trubayev Oleksandr , Larin Andrew , Prykhodko Nazar
Published: October 2024

The article discusses the issues of modeling boundary conditions for calculating the natural frequencies of a cylindrical straight pipe based on finite element models. For this purpose, various types of models were used, including rod (Pipe), shell (Shell) and solid (Solid). The study examines various options for implementing the conditions of hinged and rigid fastening: at two points, four points, along the middle surface of the pipe for the Shell model, along the end surface or along part of the outer surface of the pipe for the Solid model. The results of the study showed that the Pipe model provides a better approximation to the analytical solution. For the Shell and Solid models, when hinged, the best option for limit conditions to get closer to the analytical results is to fasten on each edge of the pipe at two points through which the neutral line of the cross-section of the pipe passes during bending. For rigid fastening, the results obtained from the Shell model are closest to the analytical solution if the fastening is carried out at four points or along the line of the middle surface of the pipe. For the Solid model, fastening along the end or part of the outer surface of the pipe is most effective. An analysis of the vibration modes showed that under different fastening conditions vibration modes arise that are associated with the deformation of the pipe as a shell. An assessment of the convergence of the obtained results was given, which confirmed the adequacy of the finite element models. The conclusions from the study made it possible to determine effective ways to set boundary conditions for the Shell and Solid models, which is also confirmed by the preliminary experimental studies of the authors. To obtain clearer results when determining the natural frequencies of pipeline systems, it is recommended to use experimental research methods along with numerical ones. The results obtained are of practical importance for solving problems of design and resource assessment of pipeline systems in various fields of industry.
GEOMETRICLY NONLINEAR BENDING OF FUNCTIONAL-GRADIENT SHALLOW SHELLS ON AN ELASTIC FOUNDASHION
Authors: Liubytska Kateryna , Morachkovska Iryna , Timchenko Galina
Published: October 2024

The paper considers the problem of geometrically nonlinear bending of shallow elements of structures made of functional gradient materials (FGM) under the influence of various transverse loads. The shallow shells under consideration can have arbitrary plan shapes and be in contact with an elastic base of the Winkler-Pasternak type. The mathematical formulation is made within the framework of classical geometric-nonlinear theory. To linearize the nonlinear system of differential equations of equilibrium, the sequential load method in combination with Newton's method is used. The effective mechanical properties of FGM vary along the thickness and are calculated according to the power law. The use of the theory of R-functions made it possible to build the necessary systems of coordinate functions for shells with arbitrary geometry and support conditions. The proposed approach is implemented in software, tested, and applied to solve the problems of bending shallow shells of complex plan shapes with holes. The influence of the elasticity coefficients of the base, the gradient index in the distribution of metal and ceramic particles, as well as other parameters on the deflections of structural elements, was studied.
Dual-Mobility Articulations in Revision Total Hip Arthroplasty
Authors: Khatod Monti , Chan Priscilla H. , Prentice Heather A. , Fasig Brian H. , Paxton Elizabeth W. , Reddy Nithin C. , Kelly Matthew P.
Published: October 2024

Background:

The increased availability of dual-mobility acetabular constructs (DMCs) provides surgeons with a newer option to increase the effective femoral head size in revision total hip arthroplasty (rTHA). We sought to evaluate risks of re-revision and prosthetic dislocation following rTHA involving a DMC compared with other articulations.

Methods:

A cohort study was conducted using data from a U.S. integrated health-care system’s Total Joint Replacement Registry. Adult patients who underwent primary THA and went on to undergo an aseptic rTHA in 2002 to 2022 were identified. Patients who received a DMC, a constrained liner, or a metal or ceramic unipolar femoral head on highly cross-linked polyethylene (XLPE) at the time of rTHA were the treatment groups. Subsequent aseptic re-revision and dislocation were the outcomes of interest. Multivariable Cox proportional-hazards regression was used to evaluate the risks of the outcomes, with adjustment for patient, operative, and surgeon confounders.

Results:

The analyzed rTHAs comprised 375 with a DMC, 268 with a constrained liner, 995 with a <36-mm head on XLPE, and 2,087 with a ≥36-mm head on XLPE. DMC utilization increased from 1.0% of rTHAs in 2011 to 21.6% in 2022. In adjusted analyses, a higher re-revision risk was observed for the constrained liner (hazard ratio [HR] = 2.43, 95% confidence interval [CI] = 1.29 to 4.59), <36 mm on XLPE (HR = 2.05, 95% CI = 1.13 to 3.75), and ≥36 mm on XLPE (HR = 2.03, 95% CI = 1.19 to 3.48) groups compared with the DMC group. A higher dislocation risk was observed in both XLPE groups (<36 mm: HR = 2.04, 95% CI = 1.33 to 3.14; ≥36 mm: HR = 2.46, 95% CI = 1.69 to 3.57) compared with the DMC group; a nonsignificant trend toward a higher dislocation rate in the group with a constrained liner than in the DMC group was also observed.

Conclusions:

In a large U.S.-based cohort, rTHAs using DMCs had the lowest re-revision risk and dislocation risk. Both outcomes were significantly lower than those using a unipolar femoral head on XLPE, re-revision risk was significantly lower than using a constrained liner, and dislocation risk trended toward a lower risk than using a constrained liner.

Level of Evidence:

Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
TEKNOLOGI PERANGKAT MEDIA PEMBELAJARAN UNTUK MENINGKATKAN KUALITAS BELAJAR SISWA
Authors: Astuti Arin Yuli , Az-Zahra Rifqi Rahmatika , Abdurozzaq Ismail
Published: October 2024

Pembelajaran yang menarik merupakan suatu keberhasilan dalam menyerap pengetahuan/ ilmu. Namun dalam hal ini banyak sekali permasalahan yang terjadi khususnya saat melakukan ujian. Tidak sedikit dari siswa yang masih mengandalkan jawaban dari teman sehingga munculnya tingkat kecurangan sangat tinggi. Hal tersebut terutama muncul pada ujian pilihan ganda, sehingga memudahkan antar siswa saling bertanya/ mencontek jawaban dari siswa lainnya. Dalam meningkatkan kualitas ilmu pengetahuan perlu adanya sebuah sentuhan teknologi yang mampu memberikan inovasi dan juga fasilitas yang lebih cepat dalam menangkap ilmu pengetahuan. Dengan merancang sebuah sistem dengan pengacakan soal, diharapkan ada inovasi yang lebih menarik dalam memberikan kuis ataupun ujian dikelas. Untuk membangun sistem pembelajaran dengan teknologi digital maka penulis akan menggunakan algoritma Fisher-Yates. Dimana algoritma ini akan membantu dalam sistem pengacakan soal untuk menjawab pertanyaan yang ada dalam materi di aplikasi yang digunakan. Dengan perancangan sistem pengacakan soal diharapkan anntinya tidak ada lagi pertanyaan yang sama di nomor yang sama, sehingga akan mengurangi tindakan kecurangan dikalangan siswa. Untuk mengetahui tingkat keberhasilan dalam menerapkan teknologi digital ini maka akan dibutkan suatu angket perbandingan yang dapat dilihat hasil dari sistem pembelajaran sebelum dan sesudah melakukan pembelajaran dengan media teknologi digital yang dibagun.
Pengaruh Model Pembelajaran Project Based Learning Dengan Pendekatan TPACK Terhadap Hasil Belajar Siswa Pada Materi Jaringan WLAN
Authors: Auria Vivia , Arif Muchamad , Ningsih Puji Rahayu
Published: October 2024

Penelitian ini bertujuan untuk mengetahui pengaruh model pembelajaran project based learning dengan pendekatan TPACK terhadap hasil belajar siswa pada materi jaringan WLAN, berserta aktivitas keterlaksanaan pembelajaran dan respon siswanya. Penelitian ini menggunakan metode kuantitatif dengan model penelitian eksperimen.  Populasi yang digunakan sebanyak 60 siswa kelas X TKJ di SMKN 1 Sepulu, dimana 30 siswa kelas X TKJ 1 sebagai kelas eksperimen dan 30 siswa kelas X TKJ 2 sebagai kelas kontrol. Peneliti menggunakan pretest, posttest, wawancara, observasi, dan angket untuk mengumpulkan data. Berdasarkan hasil penelitian diperoleh,(1) Terdapat pengaruh model pembelajaran project based learning dengan pendekatan TPACK dengan hasil belajar siswa(ranah kognitif) berdasarkan uji siggnifikan dengan hasil thitung lebih dari ttabel atau 2,284 lebih dari 2,048, sehingga H­­a diterima.(2) Aktivitas pelaksanaan pelaksanaan pembelajaran menggunakan model project based learning dengan pendekatan TPACK menunjukkan hasil baik.aktivitas guru memperoleh presentase 85,62% dengan kategori “baik” dan aktivitas siswa memperoleh presentase 86,93% dengan kategori “baik”.(3) Respon siswa pada pembelajaran dengan model project based learning dengan pendekatan TPACK memperoleh presentase 83,53% berkategori baik dari siswa. Sehingga dapat disimpulkan bahwa terdapat pengaruh model pembelajaran project based learning dengan pendekatan TPACK terhadap hasil belajar siswa pada mata pelajaran jaringan WLAN kelas X TKJ di SMKN 1 Sepulu
Implementasi Sistem Informasi Recruitment Tenaga Kerja Berbasis Web pada Aplikasi BKK SMKN 1 Tulungagung
Authors: Primajaya Grezio Arifiyan , Mu’arifin Mu’arifin , Mustaqim Dimas Purbo Choirul
Published: October 2024

Rekrutmen merupakan proses penting untuk mendapatkan calon tenaga kerja yang berkualitas. Tujuan dari perekrutan yang diadakan di SMKN 1 Tulungagung adalah untuk mendapatkan kandidat di suatu lowongan kerja, setelah sebuah lowongan diisi oleh kanidat kemudian dilakukan proses seleksi, proses seleksi bertujuan untuk mendapatkan kandidat sesuai kriteria tenaga kerja sebuah perusahaan, aktivitas rekrutment tidak terbatas untuk para siswa atau alumni SMKN 1 Tulungagung saja tetapi bisa mengakomodir kanidat yang berasal dari luar SMKN 1 Tulungagung. Namun, terdapat permasalahan dalam sistem pengelolaan data penjadwalan rekrutmen di SMKN 1 Tulungagung. Sistem tersebut masih manual dan tidak terotomatisasi, sehingga menyebabkan proses rekrutmen menjadi kurang efisien dan akurat. Untuk mengatasi permasalahan tersebut, SMKN 1 Tulungagung mengembangkan sistem informasi recruitment berbasis web. Sistem ini dirancang untuk meningkatkan efisiensi proses rekrutmen, meningkatkan kualitas tenaga kerja yang direkrut, dan menghemat biaya. Sistem ini memiliki fitur-fitur canggih, seperti fitur analisis data kandidat, fitur daftar rekrutmen, fitur notifikasi email, fitur export data hadir dengan output pdf, dan fitur export daftar peserta. Dengan adanya sistem informasi recruitment ini, SMKN 1 Tulungagung dapat menghemat waktu dan tenaga yang sebelumnya diperlukan dalam proses rekrutmen. Selain itu, sistem ini juga dapat membantu SMKN 1 Tulungagung untuk meningkatkan efisiensi proses rekrutmen dan mendapatkan tenaga kerja yang berkualitas sesuai dengan kriteria perusahaan.
UPAYA PENINGKATAN HASIL BELAJAR PADA MATA PELAJARAN BAHASA INDONESIA MELALUI MEDIA PEMBELAJARAN DIGITAL KELAS 1 MI DI TAUFIQ LAKARSANTRI SURABAYA
Authors: Novianti Ika , Suartiningsih Wahyu , Istiq'faroh Nurul , Effindi Muhamad Afif
Published: October 2024

Bahasa Indonesia adalah bahasa nasional yang digunakan dalam berbagai aspek kehidupan sehari-hari, mulai dari kegiatan Pendidikan, politik hingga bisnis. Pembelajaran bahasa Indonesia berperan penting dalam Pendidikan, karena mata Pelajaran bahasa Indonesia menjadi sarana untuk bernalar dan berpikir kritis. Kegiatan pembelajaran bahasa Indonesia harus diimplementasikan dengan baik agar memperoleh hasil yang maksimal. Peneliti menemukan hasil belajar yang rendah pada materi merawat anggota tubuh mata Pelajaran Bahasa Indonesia pada siswa kelas 1 Madrasah Ibtidaiyah At Taufiq Lakarsantri Surabaya. Sebagai upaya melakukan perbaikan hasil belajar peneliti menggunakan metode Penelitian Tindakan Kelas dengan model spiral Stephen Kemmis dan taggart dengan menggunakan media pembelajaran digital. Penelitian ini bertujuan untuk mendeskripsikan Upaya meningkatkan hasil belajar Mata Pelajaran Bahasa Indonesia Melalui Media Pembelajaran Digital Kelas 1 MI At Taufiq Lakarsantri Surabaya. berdasarkan hasil penelitian diketahui ketuntasan klasikal pra siklus yaitu 50%, setelah diberi Tindakan pada Siklus I mengalami peningkatan hasil belajar menjadi 67% dan mengalami peningkatan kembali menjadi 88% setelah dilakukan Tindakan pada Siklus II. Kesimpulan yang diperoleh adalah hasil belajar siswa mengalami peningkatan dari kualifikasi cukup menjadi kualifikasi sangat baik.
Pengembangan E-Modul Berbasis CTL Materi Suhu dan Kalor Di Kelas XI SMA Negeri 1 Torjun
Authors: Biroso Syaidin Joyo , Saputro Sigit Dwi
Published: October 2024

Buku merupakan sumber belajar yang memegang peranan penting kesuksesan dari peserta didik. Banyaknya visualisasi pada pembahasan suhu dan kalor tidak dapat difasilitasi oleh buku teks. Modul elektronik (E-Modul) menjadi penting untuk dapat menjelaskan suhu dan kalor secara kontekstual. Penelitian ini bertujuan untuk mengembangan modul elektronik berbasis CTL (Contextual Teaching and Learning) materi suhu dan kalor di kelas XI  SMA. Penelitian ini menggunakan model penelitian ADDIE yang mempunyai beberapa tahapan seperti Analysis (analisis), Design (perencanaan), Development (pengembangan), Implementation (penerapan), Evaluation (evaluasi). Subjek penelitian siswa kelas XI SMAN 1 Torjun dengan instrument penelitian meliputi lembar validasi dan angket respon siswa. Hasil dari penelitian ini memiliki kriteri sangat valid karena mendapatkan 88% dari ahli media, 84% dari ahli materi, 94,78% dari ahli konstruk, sedangkan dari uji coba kelompok kecil mendapatkan hasil 82.7% dan uji kelompok besar mendapatkan hasil 87,9% dengan kriteria interpretasi sangat baik. Dapat disimpulkan bahwa pengembangan E-Modul berbasis CTL materi suhu dan kalor di kelas XI SMA layak digunakan.
Mechanism and Data Fusion Method for Predicting Wear and Life of Polycrystalline Diamond Compact Bits Based on the Gaussian Process Regression
Authors: Yan Zhi , Fan Honghai , Song Xianzhi , Zhang Hongbao , Zhu Zhaopeng , Liu Yuhan , Diao Haoyu , Ye Yuguang
Published: October 2024

Subterranean oil and gas reserves are abundant, offering significant potential for exploration and development. However, oil and gas drilling often suffers from low efficiency due to the dense rock layers encountered. A major cause of this inefficiency is the rapid wear of bits, which significantly reduces their performance. This not only increases the time spent on inefficient drilling but also leads to frequent bit changes, adding to nonproductive time.

Therefore, this study focuses on the wear prediction of the widely used polycrystalline diamond compact (PDC) bit in oil and gas drilling operations. In this study, we focused on exploring and validating the smooth wear failure mode of PDC bits in sandstone and mudstone formations. Based on this pattern, we modified the traditional wear mechanism model to suit a data-driven approach and integrated the nonparametric intelligent algorithm, Gaussian process regression (GPR), which performs well with small sample data, for characterizing bit performance. Finally, we applied an adaptive differential evolution (ADE) algorithm to extract the cumulative wear characteristics curve that leads to the degradation of bit performance.

This method has been applied to multiple wells in the southwestern China block and the South China Sea block, achieving more than 90% accuracy in model predictions with small sample data. Furthermore, when this method is incorporated into an engineering parameter optimization model, it further unlocks the potential for bit penetration. In practical field applications, it not only enhances the bit footage but also significantly improves overall time efficiency by 11% and 59%, respectively. The application of this method can assist field engineers in identifying inefficient states in oil and gas drilling operations, thereby reducing nonproductive operation time and guiding engineering parameters to enhance drilling efficiency.
Identification of channel shifting patterns and bank erosion-prone sites and challenges of riverine livelihood in the lower Tista River Basin, India
Authors: Mitra Rajib , Das Jayanta
Published: October 2024

River channels shifting and bank erosion behaviour in fluvial environments often vary and are caused by both physical and anthropogenic elements. Riverine hazards like bank erosion and course alterations offer severe issues to the riparian villages along the lower basin of the Tista River in Jalpaiguri and Koch Bihar District of India, which substantially influence the livelihoods and essential satisfaction of people living there. This research addressed river channel shifting tendency and identified major bank erosion-prone villages along the lower course of the Tista River and challenges to the livelihoods of the riparian inhabitants. Along with these, land use and land cover changes of the riparian villages since 1993–2023 have been assessed with accuracy testing based on Kappa co-efficient. The results of this study observed that on the right bank of the Tista River, migration is occurring at a rapid pace. Due to the consequences of numerous riverine hazards, the demographic profile of the riparian villages (viz., Case Study-I: Domohani village in Jalpaiguri District) exhibited a negative tendency in the rate of population growth. The study of the riparian villages' changes in land use and cover reveals 20% decrease in vegetation cover, and both sandbars and water bodies witnessed a declining quantity. The household survey was conducted based on Cochran's method (1963); acquired results demonstrated that floods, bank erosion, and the Tista River's channel shifting behaviour negatively impacted the majority (more than 80%) of the inhabitant's income. The continuous erosion threatens the stability of the riparian villages and necessitates measures to protect riverbanks and prevent further damage. By acknowledging these hazards and implementing appropriate measures, riparian villages can enhance their resilience, protect their livelihoods, and ensure the well-being of their communities in the face of these natural threats.
The Australian clinical trial landscape: Perceptions of rural, regional, and remote health service capacity and capability
Authors: Pinchbeck Jenna , Johnston Karen , Farrington Alison , McPhail Steven , Larkins Sarah
Published: October 2024

Background: Access to clinical trials by rural, regional, and remote Australians is limited, adding to the current health inequity between rural and metropolitan populations. The Australasian Teletrial Model was developed to bring clinical trials ‘closer to home’. In 2020, the Australian Teletrial Program was funded to expand and support the uptake of the model across six Australian states and territories. The aim of this study was to explore and describe the clinical trial landscape in Australia prior to the implementation of the Australian Teletrial Program with a particular focus on rural, regional and remote health services.
Methods: This qualitative study provides a descriptive exploration of the clinical trial landscape across rural, regional, and remote Australia. Data were obtained from semi-structured interviews (n=33) and one focus group (n=5) involving clinical trial stakeholders between August 2022 and May 2023. Deductive then inductive thematic analysis used the broad topic areas of the interview schedule as a framework, as follows: education and training, workforce, equipment and services, clinical trial sites, participant recruitment and clinical trial approval process.
Results: This study identified barriers that are generalizable to the Australian clinical trial landscape and those specific to the rural, regional, and remote health service context. The main barriers to conducting clinical trials in rural, regional, and remote areas were lack of investment and engagement by health service executives, workforce limitations, inconsistent training, lack of physical infrastructure and competing clinical priorities. Despite these challenges, clinicians reported enthusiasm to conduct clinical trials and opportunities were reported for these health services to partner with larger metropolitan/regional health services, regional universities, and communities to support the growth of clinical trial capability and capacity.
Conclusions: The clinical trial landscape in Australian health services varies in terms of quality and availability of training, workforce capacity, executive support, site capability, and approval processes. The ATP has an immense opportunity to overcome some of the reported challenges by supporting capacity and capability building. Ultimately, however, sustainable reform to bring trials closer to home requires a collaborative approach that considers implementation strategies across all levels of the health service and government, alongside other initiatives.
The effect of timing on handgrip strength test in the determination of malnutrition status in patients undergoing haemodialysis therapy
Authors: Cremona Alexandra , McCarthy Rachel , Fitzgerald Jane , Kilkelly Alex , Hayes Kevin , Reddan Donal
Published: October 2024

Background
The incidence of end-stage renal disease (ESRD) in Ireland has increased by 2.3% annually over the last decade. Patients undergoing haemodialysis are particularly susceptible to protein-energy malnutrition (PEM), a critical predictor of morbidity and mortality. The subjective global assessment (SGA) tool is commonly used to assess nutritional status, but its effectiveness in detecting malnutrition within this cohort remains uncertain. Similarly, handgrip strength (HGS) has been proposed as an indicator of PEM due to its association with poorer renal outcomes. However, there is no standardized protocol for HGS measurement, and data on the optimal timing of assessment are limited.
Aim
This study aims to determine the optimal timing for HGS measurement to assess malnutrition status in patients receiving haemodialysis treatment.
Methods
A total of 101 participants were recruited from dialysis units in Galway, Ireland. The SGA tool and three repeated HGS measures were administered to each patient before, during, and after dialysis. Malnutrition status was assessed using the SGA tool and the Irish Nutrition and Dietetic Institute (INDI) HGS reference values.
Results
The sample comprised 101 participants (64.4% males, 35.6% females) with a median age of 69 years (range: 30–95). Pre-dialysis HGS measurements were higher than those recorded during dialysis (median: 23.5kg [IQR: 16.3] vs. 22.7kg [IQR: 14.7], p < 0.0001). No significant difference was found between pre- and post-dialysis measurements (23.5kg [IQR: 16.3] vs. 23.0kg [IQR: 14.8], p = 0.052). HGS values during dialysis were lower than post-dialysis (22.7kg [IQR: 14.7] vs. 23.0kg [IQR: 14.8], p = 0.047). The SGA identified 18.8% (n = 19) of participants as malnourished, with 16.8% (n = 17) being mildly/moderately malnourished and 2% (n = 2) severely malnourished. In contrast, 64.4% (n = 65) were considered at risk of PEM according to the INDI reference values for HGS.
Conclusions
Pre-dialysis HGS measurements were the highest among the three time points, indicating that HGS should be measured before haemodialysis to assess nutritional status accurately. The SGA tool showed limited sensitivity in detecting malnutrition compared to the INDI reference values for HGS.
Prevalence of Fatigue and Perceived Fatigability in Older Adults: A Systematic Review and Meta-analysis
Authors: Hu Ting , Wang Feiling , Duan Qiuchen , Zhao Xueyang , Yang Fen
Published: October 2024

Fatigue is a common health complaint in older adults, but its prevalence varies widely among studies due to differences in populations and assessment tools. The object of this review is to systematically evaluate the prevalence of fatigue and perceived fatigability in older adults. Four major public databases (PubMed, Embase, Web of Science (WoS), and Cochran Library) were searched for eligible studies on the prevalence of fatigue and perceived fatigability in older adults from January 1, 2000 to December 27, 2023. Cochrane Q tests and the I2 statistic were used to assess between-study heterogeneity via Stata16.0. A total of 21 studies involving 17843 participants were included in this study. The prevalence of fatigue in older adults was 42.6%, and the prevalence of perceived physical fatigability and mental fatigability was 58.2% and 24.0%. Meta-analysis showed that the prevalence of perceived physical fatigability among older adults was very high, which varied with regional economic development level, age of the subjects, sample size and representativeness of the subjects. Fatigue is a health dilemma faced by most older adults. To improve quality of life, early and regular fatigue assessment should be part of routine health screening for older adults.
Rare Presentation of Cervical Choriocarcinoma with Metastasis: A Case Report
Authors: Haider Javeria , Mahmood Humera , Faheem Muhammad , Khurshid Shaista , MBBS Abdullah
Published: October 2024

Introduction:
Choriocarcinoma of the cervix is an extremely rare sporadic disease with an incidence of 0.76 to 4%. This malignant form of gestational trophoblastic disease typically originates in the uterus but can occasionally arise in the vagina, fallopian tubes, vulva, cervix, or pelvic region.
Case Presentation:
Our patient presented with heavy menstrual bleeding and elevated B-HCG levels. She underwent total hysterectomy with bilateral salpingo-oophorectomy (TAH + BSO). Histopathological diagnosis confirmed choriocarcinoma and a post-treatment CT scan revealed lung metastasis. Treatment usually involves combination chemotherapy, which is highly effective, with cure rates reaching 100% in low-risk patients and 80–90% in high-risk patients.
Conclusion:
This report highlights the importance of a meticulous, multidisciplinary approach in managing patients who present with choriocarcinoma at unusual sites like cervix that can easily be missed and misdiagnosed.