bluuebunny/crossref_metadata_2025 huggingface dataset:
Preparation and Characterization of a Hydrophilic Polysulfone Membrane Using Graphene Oxide
Authors: Nguyen Hoan Thi Vuong , Ngo Thu Hong Anh , Do Khai Dinh , Nguyen Minh Ngoc , Dang Nu Thi To , Nguyen Tham Thi Hong , Vien Vo , Vu Tuan Anh
Published: June 2019

In general, the polysulfone (PSf) membranes are popular choices for water treatment because they have high thermal stability and good chemical resistance. On the other hand, the filtration capacity of the polysulfone membrane is limited because of its low water flux and poor antifouling ability, which are caused by the low surface hydrophilicity of the membranes. In this research, blending of graphene oxide (GO) or graphene oxide-titanium dioxide (GO-TiO2) mixture into the polysulfone matrix had been carried out through the phase inversion method to enhance the hydrophilic and antifouling properties. Methods such as energy-dispersive X-ray spectroscopy, scanning electron microscopy, Fourier transform infrared spectroscopy, and water contact angle measurement were used to examine the surface properties of the prepared membranes. Experimental results have led to a conclusion that graphene oxide can be stabilized into prepared membranes, and then, by reducing the water contact angle values, the surface of these membranes becomes hydrophilic, which increases the permeability and the water flux of methylene blue from the aqueous feed solution, improving the membrane’s antifouling resistance.
Global Dynamics of a Prey-Predator Model with Antipredator Behavior and Two Predators
Authors: Li Chentong , Zhang Yingying , Xu Jinhu , Zhou Yicang
Published: June 2019

In this work, we establish a new model of one prey and two predators with antipredator behavior. The basic properties on the positivity and boundedness of solutions and the existence of equilibria are established. Through analyzing the global dynamics, we find that there exist some values of the parameters such that one of the predators can be driven into being extinct by another. Furthermore, the coexistence of the three species is investigated which shows that the antipredator behavior makes the species coexist by periodic oscillation. The results give a new insight into the influence of antipredator behavior in nature selection.
Spatiotemporal Patterns Induced by Hopf Bifurcations in a Homogeneous Diffusive Predator‐Prey System
Authors: Lin Meng , Chai Yanyou , Yang Xuguang , Wang Yufeng
Published: June 2019

In this paper, we consider a diffusive predator‐prey system where the prey exhibits the herd behavior in terms of the square root of the prey population. The model is supposed to impose on homogeneous Neumann boundary conditions in the bounded spatial domain. By using the abstract Hopf bifurcation theory in infinite dimensional dynamical system, we are capable of proving the existence of both spatial homogeneous and nonhomogeneous periodic solutions driven by Hopf bifurcations bifurcating from the positive constant steady state solutions. Our results allow for the clearer understanding of the mechanism of the spatiotemporal pattern formations of the predator‐prey interactions in ecology.
Effects of Royal Jelly Administration on Lipid Profile, Satiety, Inflammation, and Antioxidant Capacity in Asymptomatic Overweight Adults
Authors: Petelin Ana , Kenig Saša , Kopinč Rok , Deželak Matjaž , Černelič Bizjak Maša , Jenko Pražnikar Zala
Published: June 2019

Objectives. Obesity and overweight are chronic disorders of multifactorial origin that are characterized by high oxidative status and by chronic activation of macrophages in peripheral tissues. Effective therapeutic approaches to lower inflammation and oxidative stress are currently of general interest. Royal jelly (RJ) is a functional food with a broad range of pharmacological activities, mainly used by healthy individuals or borderline patients to protect themselves against disease onset. The objective of this randomized, double-blind, placebo-controlled trial was to investigate the effects of RJ supplementation on metabolic profile and oxidative and inflammatory parameters in asymptomatic overweight adults, considered at an early stage of developing metabolic syndrome. Material and Methods. The experimental group (n=30) was given RJ and the control group (n=30) was provided with a placebo for eight weeks. Anthropometric, biochemical parameters, biomarkers of oxidative stress, and inflammation were assessed at baseline, after 4 and 8 weeks of the intervention, and after additional 2 weeks of follow up. Results and Conclusion. Compared with the placebo, RJ supplementation demonstrated a statistically significant decrease in total cholesterol (6.7%; p=0.041) and inflammatory marker C-reactive protein (19%; p=0.027), whereas significant increases were observed in anti-inflammatory marker adiponectin (34%; p=0.011), endogenous antioxidants bilirubin (35%; p=0.002) and uric acid (5%; p=0.018), total antioxidant capacity in serum (54%; p=0.005), and leptin (17%; p=0.025). The present study demonstrated positive effects of RJ administration on lipid profile, satiety, inflammation, and antioxidant capacity in overweight adults. Therefore, our study supports the benefits of RJ supplementation for the improvement of human health.
Cytoprotective Effect ofLigustrum robustumPolyphenol Extract against Hydrogen Peroxide-Induced Oxidative Stress via Nrf2 Signaling Pathway in Caco-2 Cells
Authors: Chen Jiayi , He Fangting , Liu Sijing , Zhou Tao , Baloch Saira , Jiang Chunping , Pei Xiaofang
Published: June 2019

Ligustrum robustumis a traditional herbal tea that is widely distributed in southwest China. The health effects ofL. robustumare characteristics of clearing heat, antioxidant, inducing resurgence, and improving digestion. However, the molecular mechanisms related to these effects, particularly the antioxidant mechanism, have been seldom reported. The objective of this study was to assess antioxidative capacity ofL. robustum, and its protective effects and mechanisms against hydrogen peroxide (H2O2) - induced toxicity in Caco-2 cells. Total phenolic contents, free radical scavenging activity, and reducing capacity ofL. robustumwere measured. The effects ofL. robustumon the cell viability and antioxidant defense system were explored. The expression of nuclear factor E2 related factor 2 (Nrf2) and antioxidant genes: quinone oxidoreductase 1 (NQO1), heme oxygenase-1 (HO-1), and glutamate cysteine ligase (GCL) were analyzed by western blot and qPCR. Pretreatment ofL. robustumcould significantly reduce H2O2-induced toxicity, decrease the level of reactive oxygen species (ROS) and malondialdehyde (MDA), and increase the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), and glutathione reductase (GR). By activating the expression of Nrf2 and antioxidant genes (NQO1, HO-1, and GCL),L. robustumexerts cytoprotective effect in Caco-2 cells dealt with H2O2. Therefore, the well-established model of Caco-2 cells demonstrates thatL. robustummay modulate the cytoprotective effect against the H2O2-induced oxidative stress through the Nrf2 signaling pathway.
Prepregnancy Obesity, Maternal Dietary Intake, and Oxidative Stress Biomarkers in the Fetomaternal Unit
Authors: Ballesteros-Guzmán Ana Karen , Carrasco-Legleu Claudia E. , Levario-Carrillo Margarita , Chávez-Corral Dora Virginia , Sánchez-Ramírez Blanca , Mariñelarena-Carrillo Edgar Omar , Guerrero-Salgado Fabiola , Reza-López Sandra Alicia
Published: June 2019

Background. Obesity and pregnancy increase levels of maternal oxidative stress (OS). However, little is known about the maternal, placental, and neonatal OS status. Objective. To analyze the relation between prepregnancy obesity and the expression of OS markers and antioxidant capacity in the fetomaternal unit and their association with dietary intake. Methods. This cross-sectional study included 33 women with singleton, noncomplicated pregnancies. Two groups were formed: women with prepregnancy body mass index (pBMI) within normal range (18.5-24.9 kg/m2, n = 18) and women with pBMI ≥ 30 kg/m2, suggestive of obesity (n = 15). Dietary and clinical information was obtained by questionnaire and from clinical records. Total antioxidant capacity (TAC) and malondialdehyde (MDA) concentration were measured on maternal and cord serum by colorimetric techniques, and placental expression of glutathione peroxidase 4 (GPx4) was measured by immunohistochemistry. Results. Placental GPx4 expression was lower in the group with pBMI suggestive of obesity than in the normal weight group (ß = -0.08, p = 0.03, adjusted for gestational age and magnesium intake). Concentrations of TAC and MDA in maternal and cord blood were not statistically different between groups (p>0.05). Cord MDA concentration was related to maternal MDA concentration (ß = 0.40, p < 0.01), vitamin A intake (tertile 2: ß = -0.04, p = 0.40, tertile 3: ß = 0.13, p = 0.03, vs tertile 1), and placental GPx4 expression (ß = -0.09, p = 0.02). Conclusion. Prepregnancy obesity is associated with a decrease in GPx4 expression in the placenta, which is related to OS in the newborn. The influence of micronutrient intake on OS biomarkers highlights the importance of nutritional assessment during pregnancy and adequate prenatal care.
The Development and Lifetime Stability Improvement of Guanosine-Based Supramolecular Hydrogels through Optimized Structure
Authors: Chen Miao , Lin Weimin , Hong Le , Ji Ning , Zhao Hang
Published: June 2019

Guanosine is an important building block for supramolecular gels owing to the unique self-assembly property that results from the unique hydrogen bond acceptors and donor groups. Guanosine-derived supramolecular hydrogels have promise in the fields of drug delivery, targeted release, tissue engineering applications,etc.However, the property of poor longevity and the need for excess cations hinder the widespread applications of guanosine hydrogels. Although guanosine-derived supramolecular hydrogels have been reviewed previously by Dash et al., the structural framework of this review is different, as the modification of guanosine is described at the molecular level. In this review, we summarize the development and lifetime stability improvement of guanosine-based supramolecular hydrogels through optimized structure and elaborate on three aspects: sugar modification, base modification, and binary gels. Additionally, we introduce the concept and recent research progress of self-healing gels, providing inspiration for the development of guanosine-derived supramolecular hydrogels with longer lifespans, unique physicochemical properties, and biological activities.
Evaluation of Shared Space to Reduce Traffic Congestion
Authors: Frosch Colin , Martinelli David , Unnikrishnan Avinash
Published: June 2019

Pedestrian and vehicle interactions often lead to conflicts that bring about safety, traffic congestion, and priority or right of way issues. Common methods used in the past to combat said issues have largely relied on the principle of separating the motions of pedestrians and vehicles by means of bridges, tunnels, signals, and access restrictions. A different approach known as shared space aims to solve the same problems with a less structured and defined environment which instead places more reliance on human interaction and perception. Although it has been used in multiple scenarios across Europe with success, instances of shared spaces in the United States are few. In the past, the success of shared space has mainly focused on safety, aesthetic, and pedestrian use metrics, with little quantitative knowledge regarding the traffic congestion relief benefits. This research focuses on evaluating and quantifying the traffic congestion relief abilities of shared space designs utilizing Vissim traffic microsimulation software and the economic impact these changes can make. A major pedestrian crossing location on West Virginia University’s Downtown campus along a major urban arterial was chosen as the case location upon which the model was to be built. This location posed unique aspects, which made it a prime choice for this research as the major concern for years has been traffic congestion, in addition to pedestrian safety and aesthetic appeal. The results of the analysis show that shared space can reduce vehicle travel time by up to 50% and delays by 66%.
Sum Rate of Multiuser Large-Scale MIMO in the Presence of Antenna Correlation and Mutual Coupling
Authors: Li Yusheng , An Kang , Liang Tao , Lu Weixin
Published: June 2019

A multiuser large-scale MIMO system with antenna correlation and mutual coupling is investigated in this paper. Based on the maximum signal-to-interference-plus-noise ratio (SINR) criteria, the optimal beamforming (BF) vector at the base station (BS) for each user is first obtained using statistical channel state information (CSI). Then, a closed-form expression for the achievable sum rate is derived in terms of a finite number of generalized Meijer-G functions, which is applicable to an arbitrary number of array elements and/or users, and provides an efficient means of evaluating the system performance. Finally, numerical results are provided to confirm the validity of the theoretical analysis and show the impact of various channel parameters on the system performance.
Research on the Influence of Smartphone Navigation on Driving Behavior Based on Real Vehicle Driving
Authors: Dong Chen-hao , Ma Rong-guo , Zhang Dong , Zhang Wan-ting , Wang Fang-fang
Published: June 2019

This paper discusses a study of the influence of different positions and modes of smartphone navigation devices on driving behavior based on real vehicle driving. Twenty professional drivers participated in the experiment in free-flowing traffic and good weather conditions. The eye movement and vehicle control data obtained in the experiment were used as indicators for evaluation. Comparison of the mean, variance, and significance analysis shows that a smartphone navigation device placed on the right side of the car dashboard (position 1) has less impact on driving behavior than when placed above the air conditioning vent (position 2). A smaller angle of view can increase the fixation frequency and the length of time that the driver spends looking out the windshield and reduce the range and time spent in glancing at the navigation device. Using only sound navigation (the audio group in this paper) has the least influence on driving behavior because the driver’s visual attention is not transferred inside the vehicle rather than on the road ahead, and the vehicle is operated in the most stable state. These findings have practical significance for reducing the negative influence of smartphone navigation.
Loss of ARID1A in Tumor Cells Renders Selective Vulnerability to Combined Ionizing Radiation and PARP Inhibitor Therapy
Authors: Park Youngran , Chui M. Herman , Suryo Rahmanto Yohan , Yu Zheng-Cheng , Shamanna Raghavendra A. , Bellani Marina A. , Gaillard Stephanie , Ayhan Ayse , Viswanathan Akila , Seidman Michael M. , Franco Sonia , Leung Anthony K.L. , Bohr Vilhelm A. , Shih Ie-Ming , Wang Tian-Li
Published: June 2019

Purpose:

Somatic inactivating mutations in ARID1A, a component of the SWI/SNF chromatin remodeling complex, are detected in various types of human malignancies. Loss of ARID1A compromises DNA damage repair. The induced DNA damage burden may increase reliance on PARP-dependent DNA repair of cancer cells to maintain genome integrity and render susceptibility to PARP inhibitor therapy.

Experimental Design: Isogenic ARID1A−/− and wild-type cell lines were used for assessing DNA damage response, DNA compactness, and profiling global serine/threonine phosphoproteomic in vivo. A panel of inhibitors targeting DNA repair pathways was screened for a synergistic antitumor effect with irradiation in ARID1A−/− tumors.

Results:

ARID1A-deficient endometrial cells exhibit sustained levels in DNA damage response, a result further supported by in vivo phosphoproteomic analysis. Our results show that ARID1A is essential for establishing an open chromatin state upon DNA damage, a process required for recruitment of 53BP1 and RIF1, key mediators of non-homologous end-joining (NHEJ) machinery, to DNA lesions. The inability of ARID1A−/− cells to mount NHEJ repair results in a partial cytotoxic response to radiation. Small-molecule compound screens revealed that PARP inhibitors act synergistically with radiation to potentiate cytotoxicity in ARID1A−/− cells. Combination treatment with low-dose radiation and olaparib greatly improved antitumor efficacy, resulting in long-term remission in mice bearing ARID1A-deficient tumors.

Conclusions:

ARID1A-deficient cells acquire high sensitivity to PARP inhibition after exposure to exogenously induced DNA breaks such as ionizing radiation. Our findings suggest a novel biologically informed strategy for treating ARID1A-deficient malignancies.
Combinatorial Therapy of Zinc Metallochaperones with Mutant p53 Reactivation and Diminished Copper Binding
Authors: Zaman Saif , Yu Xin , Bencivenga Anthony F. , Blanden Adam R. , Liu Yue , Withers Tracy , Na Bing , Blayney Alan J. , Gilleran John , Boothman David A. , Loh Stewart N. , Kimball S. David , Carpizo Darren R.
Published: June 2019

Chemotherapy and radiation are more effective in wild-type (WT) p53 tumors due to p53 activation. This is one rationale for developing drugs that reactivate mutant p53 to synergize with chemotherapy and radiation. Zinc metallochaperones (ZMC) are a new class of mutant p53 reactivators that restore WT structure and function to zinc-deficient p53 mutants. We hypothesized that the thiosemicarbazone, ZMC1, would synergize with chemotherapy and radiation. Surprisingly, this was not found. We explored the mechanism of this and found the reactive oxygen species (ROS) activity of ZMC1 negates the signal on p53 that is generated with chemotherapy and radiation. We hypothesized that a zinc scaffold generating less ROS would synergize with chemotherapy and radiation. The ROS effect of ZMC1 is generated by its chelation of redox active copper. ZMC1 copper binding (KCu) studies reveal its affinity for copper is approximately 108 greater than Zn2+. We identified an alternative zinc scaffold (nitrilotriacetic acid) and synthesized derivatives to improve cell permeability. These compounds bind zinc in the same range as ZMC1 but bound copper much less avidly (106- to 107-fold lower) and induced less ROS. These compounds were synergistic with chemotherapy and radiation by inducing p53 signaling events on mutant p53. We explored other combinations with ZMC1 based on its mechanism of action and demonstrate that ZMC1 is synergistic with MDM2 antagonists, BCL2 antagonists, and molecules that deplete cellular reducing agents. We have identified an optimal Cu2+:Zn2+ binding ratio to facilitate development of ZMCs as chemotherapy and radiation sensitizers. Although ZMC1 is not synergistic with chemotherapy and radiation, it is synergistic with a number of other targeted agents.
Towards a Rational and Efficient Diagnostic Approach in Children Referred for Growth Failure to the General Paediatrician
Authors: Wit Jan M. , Kamp Gerdine A. , Oostdijk Wilma ,   on behalf of the Dutch Working Group on Triage and Diagnosis of Growth Disorders in Children
Published: June 2019

Based on a recent Dutch national guideline, we propose a structured stepwise diagnostic approach for children with growth failure (short stature and/or growth faltering), aiming at high sensitivity for pathologic causes at acceptable specificity. The first step is a detailed clinical assessment, aiming at obtaining relevant clinical clues from the medical history (including family history), physical examination (emphasising head circumference, body proportions and dysmorphic features) and assessment of the growth curve. The second step consists of screening: a radiograph of the hand and wrist (for bone age and assessment of anatomical abnormalities suggestive for a skeletal dysplasia) and laboratory tests aiming at detecting disorders that can present as isolated short stature (anaemia, growth hormone deficiency, hypothyroidism, coeliac disease, renal failure, metabolic bone diseases, renal tubular acidosis, inflammatory bowel disease, Turner syndrome [TS]). We advise molecular array analysis rather than conventional karyotyping for short girls because this detects not only TS but also copy number variants and uniparental isodisomy, increasing diagnostic yield at a lower cost. Third, in case of diagnostic clues for primary growth disorders, further specific testing for candidate genes or a hypothesis-free approach is indicated; suspicion of a secondary growth disorder warrants adequate further targeted testing.
Impact of Age on Long-Term Survival in Patients with Esophageal Cancer Who Underwent Transthoracic Esophagectomy
Authors: Motoori Masaaki , Ito Yuri , Miyashiro Isao , Sugimura Keijiro , Miyata Hiroshi , Omori Takeshi , Fujiwara Yoshiyuki , Yano Masahiko
Published: June 2019

Background and Objective: Esophagectomy, which is one of the most invasive operations among gastrointestinal surgeries, deteriorates the physical condition of patients. Such deterioration may be severe in elderly patients and advanced age may negatively affect long-term survival. However, elderly patients are more likely to die from cancer-unrelated causes than younger patients. Therefore, when comparing the survival of elderly patients after cancer surgery with that of younger patients, it is necessary to control the influence of cancer-unrelated death. To address this problem, we calculated the relative survival and applied the excess hazard model to control the influence of competing risk of death from cancer. Methods: We retrospectively analyzed 505 patients with thoracic esophageal cancer who underwent transthoracic esophagectomy. Prognostic information was followed up to 10 years after surgery or until death in all patients. Prognostic information of patients lost to follow-up was retrieved from the Osaka Cancer Registry’s database. First, we identified prognostic variables as confounders of age by univariate and multivariate analysis. Then, we estimated age effects using the excess hazard model including the prognostic variables as confounders. Results: Univariate and multivariate analysis showed that clinical stage, residual tumor, and postoperative complications (p < 0.1) were confounders of age. Multivariate excess hazard model revealed that age was not a significant prognostic factor at any cutoff point. However, the excess hazard ratio of death tended to increase continuously in patients aged 70 years or older. Conclusions: When clinicians offer esophagectomy for esophageal cancer, age per se should not be a limiting factor. Strict evaluation of patients should be performed before surgery, especially in the elderly.
miR-130b Promotes Sunitinib Resistance through Regulation of PTEN in Renal Cell Carcinoma
Authors: Sekino Yohei , Sakamoto Naoya , Sentani Kazuhiro , Oue Naohide , Teishima Jun , Matsubara Akio , Yasui Wataru
Published: June 2019

Background: MicroRNAs are a class of small noncoding RNAs that play an important role in progression and drug resistance in cancer. Several reports have shown that miR-130b modulates cell growth and drug resistance in some cancers. However, the expression and biological role of miR-130b in renal cell carcinoma (RCC) remain poorly understood. This study aimed to examine the expression and functional role of miR-130b and to analyze the association between miR-130b and sunitinib resistance in RCC. Methods: The expression of miR-130b in 32 RCC tissues and their corresponding normal kidney tissues was determined by quantitative reverse transcription polymerase chain reaction (qRT-PCR). We performed a 4,5-dimethylthiazol-2-yl-2,5-diphenyltetrazolium bromide (MTT) assay in RCC cell lines transfected with miR-130b inhibitor or miR-130b mimics. We evaluated the relationship between miR-130b and PTEN and also analyzed the effect of miR-130b on sunitinib resistance. Results: qRT-PCR analysis showed that the expression of miR-130b was higher in RCC tissues than in corresponding normal kidney tissues. The MTT assay revealed that miR-130b modulated cell growth. qRT-PCR revealed an inverse correlation between miR-130b and PTEN in RCC. Western blotting demonstrated that miR-130b regulated the expression of PTEN in the RCC cell line. Additionally, miR-130b was associated with sunitinib resistance through regulation of PTEN. We established the sunitinib-resistant Caki-1 (Caki-1-SR) cells and observed that the expression of miR-130b was elevated in Caki-1-SR cells compared with parental Caki-1 cells. Knockdown of miR-130b improved sunitinib resistance in Caki-1-SR cells. Conclusion: The expression of miR-130b was upregulated in RCC. miR-130b promoted cell growth and was associated with sunitinib resistance through regulating PTEN expression. Collectively, these results suggest that miR-130b may play an oncogenic role and be a promising therapeutic target.
Kooperation in der Versorgung psychischer Störungen aus hausärztlicher, fachärztlicher und fachpsychotherapeutischer Perspektive
Authors: Dorr Florence , Maun Andy , Farin-Glattacker Erik , Fichtner Urs , Bengel Jürgen
Published: June 2019

Hintergrund: Die Kooperation von Hausärzten mit ambulant und stationär tätigen Spezialisten ist in der Versorgung bei psychischen Störungen von zentraler Bedeutung. Empirische Studien zum aktuellen Kooperationsgeschehen fehlen. Ziel war die Analyse der Zusammenarbeit von hausärztlichen, fachärztlichen und psychologisch-psychotherapeutischen Behandlern in der ambulanten und stationären Versorgung. Methode: Mittels eines Online- und postali­schen Fragebogens wurden Kooperationsformen, Probleme in der Kooperation, Kooperationsbedarf, Zufriedenheit und Verbesserungsvorschläge zur Vernetzung erhoben. Ergebnisse: Insgesamt füllten N = 504 Behandler den Fragebogen aus, darunter 108 Hausärzte, 96 ambulant und 63 stationär tätige Fachärzte sowie 216 ambulant und 21 stationär tätige psychologische Psychotherapeuten. Kooperation findet in erster Linie bei Bedarf im Einzelfall statt und basiert nur wenig auf festgelegten Strukturen und definierten Routi­nen. Obwohl sich die Teilnehmenden relativ zufrieden mit der aktuellen Kooperation zeigen, ist der wahrgenommene Bedarf an Kooperation groß. Schwierigkeiten werden v.a. aufgrund von fehlenden ambulanten Therapieplätzen, Zeitmangel, Problemen bei der Erreichbarkeit von Kollegen und wenig etablierten Kooperationsprozessen gesehen. Implikationen: Die Behandler sind grundsätzlich zufrieden, sehen aber dennoch Verbesserungsbedarf bei der Vernetzung der psychischen Versorgung. Daher ist die Optimie­rung entsprechender Strukturen und Prozesse mit dem Ziel der Verbesserung der patientenorientierten Behandlung von Menschen mit psychischen Störungen notwendig.
Inflammatory Pseudotumor of the Pancreas Mimicking a Pancreatic Neoplasm
Authors: Baião José Miguel , Martins Rui Miguel , Correia João Guardado , Jordão Daniel , Vieira Caroço Teresa , Caetano Oliveira Rui , Agostinho Paulo Gil , Ferrão Henrique
Published: June 2019

A 78-year-old woman was admitted to our hospital with a pancreatic tumor, incidentally discovered in an abdominal ultrasound exam. She was asymptomatic and without any previous personal pathological condition. The computed tomography (CT) and the magnetic resonance imaging (MRI) scan showed a mass lesion of 4 cm in diameter, located in the pancreatic body, conditioning the invasion of the splenic vein. The patient was admitted to surgery. During the laparotomy, we found a tumoral lesion highly suspicious of pancreatic neoplasia located in the transition of the head/body of the pancreas, with an invasion of the portal vein and several peri-regional lymph nodes. We performed biopsies of the pancreatic mass and lymphadenectomy of the peri-regional pancreatic lymph nodes. Histological analysis found an inflammatory pseudotumor of the head/body of the pancreas, without signals of malign epithelial neoplasm and also without criteria for immunoglobulin G4-related disease. During the follow-up, a PET/CT and MRI confirmed that the pancreatic lesion had disappeared without any treatment. Inflammatory pseudotumor of the pancreas is a rare entity not fully understood. Despite this, the administration of corticosteroids and immunosuppressive therapy could be taken into consideration as the disease carries a risk.
Moda e modas no vestuário
Authors: Dulci Luciana Crivellari
Published: June 2019

Este trabalho propõe uma análise comparativa acerca de dois momentos da moda no vestuário. O primeiro refere-se às teorias que inicialmente compreenderam o fenômeno da moda como uma hierarquia simbólica entre classes que ditam e classes que copiam moda. Esta perspectiva analítica explicou a moda desde o seu surgimento no Ocidente até meados do século XX. O segundo momento trata das modas plurais do tempo presente que, acredita-se, não podem mais ser explicadas por este primeiro cenário teórico. A investigação buscou evidenciar regularidades e singularidades entre os diferentes contextos de moda, examinando até que ponto a proposta analítica da hierarquia simbólica ainda explica as modas contemporâneas e em quais aspectos as modas plurais de hoje se diferenciam no seu movimento de renovação.
Stroke Incidence and Survival in American Indians, Blacks, and Whites: The Strong Heart Study and Atherosclerosis Risk in Communities Study
Authors: Muller Clemma J. , Alonso Alvaro , Forster Jean , Vock David M. , Zhang Ying , Gottesman Rebecca F. , Rosamond Wayne , Longstreth W.T. , MacLehose Richard F.
Published: June 2019

Background

American Indians (
AIs
) have high stroke morbidity and mortality. We compared stroke incidence and mortality in
AI
s, blacks, and whites.

Methods and Results

Pooled data from 2 cardiovascular disease cohort studies included 3182
AI
s from the SHS (Strong Heart Study), aged 45 to 74 years at baseline (1988–1990) and 3765 blacks and 10 413 whites from the ARIC (Atherosclerosis Risk in Communities) Study, aged 45 to 64 years at baseline (1987–1989). Stroke surveillance was based on self‐report, hospital records, and death certificates. We estimated hazard ratios for incident stroke (ischemic and hemorrhagic combined) through 2008, stratified by sex and birth‐year tertile, and relative risk for poststroke mortality. Incident strokes numbered 282 for
AI
s, 416 for blacks, and 613 for whites. For women and men, stroke incidence among
AI
s was similar to or lower than blacks and higher than whites. Covariate adjustment resulted in lower hazard ratios for most comparisons, but results for these models were not always statistically significant. After covariate adjustment,
AI
women and men had higher 30‐day poststroke mortality than blacks (relative risk=2.1 [95% CI=1.0, 3.2] and 2.2 [95% CI=1.3, 3.1], respectively), and whites (relative risk=1.6 [95% CI=0.8, 2.5] and 1.7 [95% CI=1.1, 2.4]), and higher 1‐year mortality (relative risk range=1.3–1.5 for all comparisons).

Conclusions

Stroke incidence in
AI
s was lower than for blacks and higher than for whites; differences were larger for blacks and smaller for whites after covariate adjustment. Poststroke mortality was higher in
AI
s than blacks and whites.
Repeat Measurements of High Sensitivity Troponins for the Prediction of Recurrent Cardiovascular Events in Patients With Established Coronary Heart Disease: An Analysis From the KAROLA Study
Authors: Jansen Henning , Jaensch Andrea , Schöttker Ben , Dallmeier Dhayana , Schmucker Roman , Brenner Hermann , Koenig Wolfgang , Rothenbacher Dietrich
Published: June 2019

Background

High‐sensitivity cardiac troponins T and I (hs‐
cTnT
and hs‐
cTnI
) are established biomarkers for myocardial injury and used for diagnostic and prognostic purposes. However, whether repeat measurements improve prediction of recurrent cardiovascular disease (
CVD
) events in patients with stable coronary heart disease (
CHD
) after adjustment for several other novel biomarkers remains unclear.

Methods and Results

We measured both troponins in 873 coronary heart disease patients from the KAROLA (Langzeiterfolge der Kardiologischen Anschlussheilbehandlung) study about 9 weeks after their initial acute event (baseline) and after 12 months, followed them for 12 years, assessed a combined
CVD
end point, and adjusted for several risk factors. As we found evidence for effect modification, results were stratified according to presence of myocardial infarction at baseline. During follow‐up, 186 fatal and non‐fatal
CVD
events occurred. Both baseline and 12‐months troponin concentrations were significantly associated with
CVD
events in patients without myocardial infarction at baseline; in tendency 12 months of troponin showed stronger hazard ratios (hs‐
cTnT
: hazard ratios 1.91 (95%
CI
1.17–3.11) versus baseline values 1.71 (95%
CI
1.08–2.70) and for hs‐
cTnI
: hazard ratio 1.55 (95%
CI
1.05–2.30) versus baseline value 1.22 (95%
CI
0.88–1.68) in the fully and simultaneously adjusted model.

Conclusions

Both troponins are consistently associated with recurrent cardiovascular events after adjustment for emerging risk factors during follow‐up in our study especially evident in patients without myocardial infarction at baseline. Troponin values at 12 months of follow‐up showed independent associations with future
CVD
events in addition to baseline assessments of troponins.
Setting The Record Straighter: Part II
Authors: Filho José Oiticica
Published: June 2019

This text introduces article “Setting the Record Straighter” (1951) by Brazilian photographer and artist José Oiticica Filho (1906–1964). The core of Oiticica Filho's article is a discussion of the significance of photo-club exhibitions, based on the example of an ongoing rivalry between the members of São Paulo-based photo club Foto Cine Clube Bandeirante (FCCB) and Rio de Janeiro-based club Sociedade Fluminense de Fotografia. Oiticica Filho, as a member of the São Paulo-based club who resided in Rio, emerged as a mediator between the two groups—an impartial scientist who sought a solution in data, not in the clashes between egos. The article, partially translated here for the first time, illuminates the inner workings of photo-club culture, the motivation for photographers to participate, and their major concerns about the club exhibitions. Oiticica Filho's method, based on statistics and data analysis, anticipate the sociological approach to photography developed by Pierre Bourdieu in Photography: A Middle-Brow Art (1965). Understanding Oiticica Filho's statistical work is key to establishing a broader perspective on postwar photo-club culture as an international phenomenon that contributed to the recognition of photography as an autonomous art form during the 1950s.
Re-Worlding Postwar
Authors: Johal Rattanamol Singh
Published: June 2019

The exhibition, Postwar: Art between the Pacific and the Atlantic, 1945–1965 (2016-17), presented nearly 350 works by 218 artists from sixty-five countries, providing an ambitious and expansive account of mid-century modernism. Curated by Okwui Enwezor, Katy Siegel, and Ulrich Wilmes at Haus der Kunst in Munich, Postwar proposed a vision of artistic production in the post-World War II period that foregrounded experiences of war, decolonization, transnational movement, and changing technology. This review situates the show within a history of global exhibitions, articulating the stakes of the project for curatorial practice and pedagogy. It also evaluates its organization and display in the institution’s gallery spaces, reckoning with the limits of the exhibition format and the mode of decentering enacted through a simultaneous presentation of works created by artists in widely varying contexts.
Funding and Directing Research or Rewarding Scientific Achievements?
Authors: Bret Patrice
Published: June 2019

This study examines the science and technology prize system of the Académie des Sciences through a first survey of the prizes granted over the period extending from the 1720s to the end of the 19th century. No reward policy was envisaged by the Royal Academy of Sciences in the Réglement (statute) promulgated by King Louis XIV in 1699. Prizes were proposed later, first by private donors and then by the state, and awarded in international contests setting out specific scientific or technical problems for savants, inventors and artists to solve. Using cash prizes, under the Ancien Régime the Academy effectively directed and funded research for specific purposes set by donors. By providing it with significant extra funding, the donor-sponsored prizes progressively gave the Academy relative autonomy from the political power of the state. In the 19th century, with the growing awareness of the importance of scientific research, the main question became whether to use the prizes to reward past achievements or to incentivize future research, and the scale and nature of the prizes changed.
How Gaspara Stampa Challenged Classical Tradition and Conventional Notions of Women’s Anger
Authors: Sardu Luisanna
Published: June 2019

The collection of Rime by the Italian sonneteer Gaspara Stampa (1523–1554) has often been compared in style and format to the Canzoniere of Petrarch. Such analysis places emphasis on Petrarch instead of Stampa, and limits discussion of her work to its relation with the literary tradition he established. Interpretation of the work of Stampa and other female authors requires a new perspective, recognising that they sought to create for themselves a literary safe space in which to convey deeply held emotional states – especially anger – and in the process to reclaim the voices and emotions of women from the male literary traditions in which they had been ensnared.
Notification concerning Planned Measures on Shared Watercourses
Authors: Salman Salman M. A.
Published: June 2019

Notification of co-riparian states of planned measures on shared watercourses has been widely accepted as an established principle of international water law, and is codified and elaborated in the United Nations Watercourses Convention. However, despite this wide acceptance, issues have arisen in operationalizing notification, and in dealing with the different types of responses that may ensue following notification. The World Bank has been financing projects on international watercourses since its inception in the late 1940s, and has built an extensive wealth of policies and experience in this field. This monograph discusses the historical and legal foundations of notification under international law, analyses the policies and implementation experience of the World Bank thereon, and identifies comparators and synergies between the provisions of the Watercourses Convention and the Bank policies and practice.
A new species of the genus Plumaroides Brothers (Hymenoptera, Chrysidoidea, Plumariidae) from Santiago del Estero, Argentina: male and female description
Authors: DIEZ PATRICIA A.
Published: June 2019

This work describes a new species of the genus Plumaroides Brothers called P. tiphlus, sp. nov. This new species was collected in the province of Santiago del Estero, Argentina. Both sexes are described for this species, and this work represents the first association and description of the female for this genus.
A new Siphonoperla species from the Eastern Alps (Plecoptera: Chloroperlidae), with comments on the genus
Authors: GRAF WOLFRAM , STRADNER DENNIS , WEISS STEVE
Published: June 2019

We describe a new species of stonefly from the genus Siphonoperla, from a glacial refuge in the Eastern Alps of Austria. The species’ unique genitalia among congenitors as well as high genetic divergence from the co-occuring Siphonoperla montana strongly support its status as a distinct species. We describe Siphonoperla ottomoogi nov. sp. based on morphological and genetic characteristics as well as provide notes on its presumed habitat and distribution. Further notes on the biogeography of the genus are provided.
The Stegana coleoptrata species group (Diptera: Drosophilidae) from mainland China
Authors: CHEN XI-PENG , CHEN HONG-WEI
Published: June 2019

Nine species of the Stegana coleoptrata species group are found from mainland China, including six newly described: S. (Stegana) melanostoma sp. nov., S. (S.) pililobasa sp. nov. and S. (S.) psilolobosa sp. nov. from Hubei Province; S. (S.) arcygramma sp. nov., S. (S.) melanostigma sp. nov. and S. (S.) monodonata sp. nov. from Yunnan Province. A key to all species of the group from the mainland China is provided.
Salticid spider phylogeny revisited, with the discovery of a large Australasian clade (Araneae: Salticidae)
Authors: MADDISON WAYNE P. , BODNER MELISSA R. , NEEDHAM KAREN M.
Published: June 2019

DNA sequence data from four gene regions (28S, 18S, 16S-ND1, and CO1) were gathered from 65 jumping spider (salticid) taxa to supplement previously gathered molecular data for the family's phylogeny. The additional taxa are mostly from Australasia and other regions of the Old World. Bayesian and parsimony analyses support a clade, here called the Astioida, representing a large proportion of the Australasian fauna. Included in the Astioida are, for example, the robustbodied Simaetha and Mopsus, the flattened bark-dweller Holoplatys, the delicate foliage-dweller Tauala, the antlike Myrmarachne and the litter-dwelling Neon. One astioid, Rhondes neocaledonicus, is returned to that genus from its placement in Hasarius. Another newly supported clade, the Aelurilloida, includes the aelurillines, the freyines, and the Bacelarella group of genera. Other newly delimited clades are the Philaeus group (Philaeus, Mogrus, Carrhotus and others), the Leptorchesteae (Leporchestes, Yllenus and Paramarpissa) and the Hasarieae (Hasarius, Habrocestum and Chinattus). These results concur with previous discoveries (e.g., Amycoida, Marpissoida) in suggesting that salticid clades are largely restricted to continental regions.
Four new species of the spider genus Cicurina Menge, 1871 from China (Araneae: Dictynidae)
Authors: WANG LU-YU , ZHOU GU-CHUN , PENG XIAN-JIN
Published: June 2019

Four new species of the genus Cicurina are described: C. daweishanensis spec. nov. (female), C. kekei spec. nov. (male and female), C. lichuanensis spec. nov. (male and female) and C. yuelushanensis spec. nov. (male and female). Photos of body and copulatory organs, line drawings of copulatory organs, as well as the locality map are provided. The type specimens of Cicurina eburnata Wang, 1994 were reexamined for the comparison of allied species. Photos of C. calyciforma Wang & Xu, 1989 are also presented in order to compare it with two new species.
Impact of Multiple Altimeter Data and Mean Dynamic Topography in a Global Analysis and Forecasting System
Authors: Hamon Mathieu , Greiner Eric , Le Traon Pierre-Yves , Remy Elisabeth
Published: June 2019

Satellite altimetry is one of the main sources of information used to constrain global ocean analysis and forecasting systems. In addition to in situ vertical temperature and salinity profiles and sea surface temperature (SST) data, sea level anomalies (SLA) from multiple altimeters are assimilated through the knowledge of a surface reference, the mean dynamic topography (MDT). The quality of analyses and forecasts mainly depends on the availability of SLA observations and on the accuracy of the MDT. A series of observing system evaluations (OSEs) were conducted to assess the relative importance of the number of assimilated altimeters and the accuracy of the MDT in a Mercator Ocean global 1/4° ocean data assimilation system. Dedicated tools were used to quantify impacts on analyzed and forecast sea surface height and temperature/salinity in deeper layers. The study shows that a constellation of four altimeters associated with a precise MDT is required to adequately describe and predict upper-ocean circulation in a global 1/4° ocean data assimilation system. Compared to a one-altimeter configuration, a four-altimeter configuration reduces the mean forecast error by about 30%, but the reduction can reach more than 80% in western boundary current (WBC) regions. The use of the most recent MDT updates improves the accuracy of analyses and forecasts to the same extent as assimilating a fourth altimeter.
Adjusted vs Total Body Weight–Based Dosing of Sedation and Analgesia Used in the Intensive Care Unit
Authors: Yeary Julianne , Greco Alexandra , McKnight Richard , Petros Karen , Schaefer Gregory , Garavaglia Jeffrey
Published: June 2019

Background: The purpose of this study was to evaluate if dosing fentanyl, dexmedetomidine, and propofol based on ideal or adjusted vs actual weight in patients would decrease overall opioid and sedative use. Methods: This was a retrospective chart review comparing adjusted vs actual weight-based dosing protocol of mechanically ventilated (MV) intensive care unit (ICU) adult patients who required fentanyl and either propofol or dexmedetomidine. Results: A total of 261 patients were included in which 101 patients were in the actual weight group and 160 patients were in the adjusted weight group. Total doses per MV day of fentanyl was 1042 ± 1060 µg in the actual weight group vs 901 ± 1025 µg in the adjusted weight group ( P = .13). Total doses per MV day of midazolam was 20 ± 19 mg in the actual group vs 15 ± 19 mg adjusted group ( P = .02). Average MV days was 8.2 vs 7.1 days, ICU length of stay was 10.6 vs 9.4 days, and self-extubation rates were 17.8% vs 4.4% in the actual group and adjusted group, respectively. Conclusion: Total midazolam doses per MV day were lower in the adjusted group. No significant change was seen in MV days, ICU length of stay, or self-extubation rates.
On the Inter-Laminar Shear Strength of Composites Manufactured via a Stepped-Concurrent UV Curing and Layering Process
Authors: Beyene Shiferaw D , Ayalew Beshah , Pilla Srikanth
Published: June 2019

In this paper, we set to examine the inter-laminar shear strength of a fiber-reinforced composite part manufactured via a stepped-concurrent ultraviolet curing and layering process. This process was specifically proposed for making epoxy-based thick parts, whereby a layer-by-layer, model-based, optimal layering time and ultraviolet control scheme is set up with the objective of minimizing the degree of cure deviation across the final thick part. We focus on a cationic curing process wherein additional energy savings are possible by switching off the ultraviolet source after initiating the curing reaction with the ultraviolet source at each layer addition. Since the inter-laminar sheer strength of parts made via a layering process is often a concern, we consider the application of in-situ consolidation pressure in the layering process. We then characterize the inter-laminar shear strength by manufacturing samples with application of different in-situ consolidation pressures and measuring the inter-laminar shear strength of each sample by the short-beam shear test. The results showed that the inter-laminar shear strength of composite parts fabricated with the proposed stepped-concurrent curing, and layering process increases with the applied consolidation pressure up to a point. Scanning electron microscopy of samples cured at different in-situ consolidation pressure showed that the sample with optimum consolidation pressure has relatively uniform fiber to resin distribution and hence improved inter-laminar shear strength.