bluuebunny/crossref_metadata_2025 huggingface dataset:
Symbolizm złotego pasa Chrystusa zmartwychwstałego (Ap 1,13) w świetle literatury greckiej
Authors: Podeszwa Paweł Adam
Published: October 2021

Artykuł podejmuje zagadnienie symbolicznego znaczenia złotego pasa Jezusa (Ap 1,13) w inauguracyjnej wizji Apokalipsy (1,12-20). Źródłem tego symbolizmu chromatycznego jest najpierw Stary Testament, w którego świetle złoty kolor wskazuje na Jezusa jako Boga, Króla i Arcykapłana. W zaproponowanej refleksji poszukuje się także możliwych źródeł (inspiracji) w antycznej literaturze greckiej, zwłaszcza w opisach bóstw mitologicznych: Zeusa, Posejdona, Artemidy, Apollona, Kirke. Ana­liza wybranych fragmentów, zaczerpniętych z Iliady i Odysei Homera oraz Hymnów Kallimacha, pozwala stwierdzić, że złoto jest ich dominującym kolorem, a wiele elementów stroju, ekwipunku i sprzętów, którymi posługują się greccy bogowie, zostało wykonanych z tego szlachetnego i cennego materiału. Można zatem powiedzieć, że barwa złota jest „kolorem bogów”, a sam kruszec kojarzy się w sposób naturalny w bóstwem. Autor Apokalipsy mógł zatem wykorzystać obrazy i motywy zapożyczone z mi­tologii i symboliki greckiej, traktując je jako materiał literacki, wyrażający symbolicznie prawdę o tran­scendencji Jezusa.
Dlaczego Mojżesz, Homer i Platon nie pisali wprost? Strategia interpretacji tekstów kanonicznych u Filona, Maksyma z Tyru i Numeniusza z Apamei
Authors: Bednarek Tomasz
Published: October 2021

Interpretacja alegoryczna była narzędziem hermeneutycznym często stosowanym w pismach myślicieli z kręgu medioplatonizmu. Pierwotnie powstała w dyskusjach nad spuścizną Homera alegoreza była wykorzystywana także przez interpretatorów Biblii oraz pism filozoficznych. Alegoreci, dostrzegający w interpretowanych tekstach wyrażenia figuratywne, byli świadomi, że przy ich dosłownym odczytaniu, są one niejasne, a czasami nawet nieprawdziwe. Celem artykułu jest analiza strategii obrony wyrażeń figuratywnych (głównie antropomorfizmów i alegorii), podjętej w utworach wybranych myślicieli medioplatońskich: Filona z Aleksandrii (Quod Deus immutabilis sit, De somniis oraz De sacrificiis Abeli et Caini), Maksyma z Tyru (Mowa IV, XVII i XXVI) oraz Numeniusza z Apamei (Fragment 23 i 24). Historyczno-filozoficzna analiza poszczególnych utworów, zawierających interpretacje pism Mojżesza, Homera i Platona, dowodzi, że obrona pism uznawanych za kanoniczne stanowiła ważny element interpretacji przeprowadzanej przez medioplatoników. Zastosowanie metody porównawczej pozwala zaś na dostrzeżenie w argumentacji medioplatońskich interpretatorów zarówno cech specyficznych dla każdego z nich, jak i elementów wspólnych, takich jak sceptyczne podejście do kompetencji intelektualnych i filozoficznych większości ludzi w poszczególnych społeczeństwach oraz przekonanie o pedagogicznej wartości języka figuratywnego i konieczności jego stosowania w komunikacji.
"Enneady" Plotyna inspiracją dla św. Jana od Krzyża w nauce o drodze do kontemplacji?
Authors: Zarzycki Stanisław
Published: October 2021

Uwzględniając wpływ neoplatonizmu na chrześcijaństwo w starożytności i w średniowieczu, autor pyta o możliwość wpływu Ennead Plotyna na naukę o drodze do kontemplacji św. Jana od Krzyża. Przybliża najpierw plotyńską wizję rzeczywistości, według której z jednej zasady, z Jednego, w procesie emanacji, wyłoniły się byty: umysł, dusza jednostkowa i dusza świata. Następnie ukazuje człowieka i jego powrót do Absolutu poprzez ascezę, kontemplację i ekstazę plotyńską. Analizując Enneady Plotyna i ich interpretację w zakresie doktryny duchowej u znanych komentatorów (A. Bord, J. Baruzi, M. de la Corte, B. Salmona, L. Bouyer), dokonuje porównania opisów wybranych momentów drogi duchowej do kontemplacji i ekstazy u dwóch mistrzów duchowych i interpretuje je z uwzględnieniem różnic doktrynalnych i duchowych pomiędzy neoplatonizmem i chrześcijaństwem. Identyfikując w opisach nieliczne podobieństwa dotyczące zwłaszcza drogi oczyszczenia i uwzględniając zasadnicze i bardziej szczegółowe różnice, przychyla się za Bordem do przyjęcia możliwej inspiracji Ennead Plotyna jedynie w pewnych aspektach opisu doświadczenia duchowego mistyka Karmelu.
Unconditional and conditional as categories of the dialectic of law
Authors: Utkin Grigory N.
Published: October 2021

The article reveals the conceptual, meaning-forming role of the categories of the unconditional and conditional in law. At the same time, their dialectical relationship with each other and with other categories is put in the center of attention. The dialectic of the unconditional and conditional is revealed by achieving the unity of the three stages of theoretical analysis, which allows us to present the unconditional and conditional, on the one hand, as the content of all concepts, through which the idea of law is generally expressed in various aspects and elements; on the other hand, the entire set of categories subject to dialectical analysis appears as elements of the content of the unconditional and conditional as semantic units that Express the universal characteristics of law in its features, isolation from other forms of social life.
Constitutional and legal foundations of the public organization of business activity within the oil sector of the energy-producing industry
Authors: Gusyakov Vyacheslav Yu.
Published: October 2021

The article deals with constitutional and legal foundations of the public organization of business activity within the oil sector of the energy-producing industry in the Russian Federation. It is on the one hand connected with the basic constitutional principles of the common economic area in the Russian Federation such as the admission of varying legal standing in relation to proprietorial right to natural resources, the obligatory normative separation of the jurisdiction between different governmental agencies, and on the other hand the mandatory legal regulation of the public organization of business activity, particularly within the oil sector. Due to this, attention is paid to the necessity of consistency regarding the legal regulation of accounting, currency transactions, tax system, sustainability issues and other most important legal bodies of business activity regulation.
Long-term degradation, damage and fracture in deep rock tunnels: A review on the effect of excavation methods
Authors: Frenelus Wadslin , Peng Hui , Zhang Jingyu
Published: October 2021

Rocks are frequently host materials for underground structures, particularly for deep Tunnels. Their behavior plays a fundamental role in the overall stability of these structures. In fact, the erection of deep tunnels imposes rocks excavations around the defined routes. These excavations are generally carried out by various methods of which the most used are Drill-and-Blast (DB) and Tunnel Boring Machine (TBM).  However, regardless of the tunnelling method used, the impacts such as the perturbation of the initial stress field in rocks and the release of the stored energy are always significant. The impacts produce damage, fractures and deformations which are generally time-dependent and influence the long-term stability of deep tunnels built in rocks. Thus, by considering the aforementioned excavation methods, this paper identifies, reviews and describes the relevant factors generated during and after rock excavations. Interestingly, such factors directly or indirectly influence the long-term stability and therefore the structural integrity of deep rock tunnels. In addition, some recommendations and proposals for future works are presented. This paper can provide useful references in understanding the degradations, damage and fractures generated by tunnelling methods and facilitate suitable actions to ensure long-term stability of deep underground structures.
Numerical prediction of the ductile damage for axial cracks in pipe under internal pressure
Authors: Fezazi Amina Ismahène , Mechab Belaïd , Mokadem Salem , Serier Boualem
Published: October 2021

This study presents a numerical prediction of the ductile damage for axial cracks in pipe subjected to internal pressure. The three dimensional finite element methods used to evaluate the J-integral. The effect of the external radius (Rext),the thickness (t), length crack (a) , the applied loads (P) and the crack position of the pipes has studied. The Monte Carlo method was used to determine the probabilistic characteristics of the J-integral. It’s also used later to predict the failure probability based on initiation of the crack growth. We note that the crack size and the geometries of the pipe are an important factor influencing on the durability of the pipe.
Influence of themo-mechanical treatments and microstructural state on the fatigue behaviour of a weald seam: case of API X60 steel
Authors: Achoui Mohammed , Sebaa Fethi , Bouchouicha Benattou
Published: October 2021

The aim of this work is the study of the fatigue behaviour of API X60 steel and the influence of thermal and mechanical treatments. The evaluation of the integrity and safety of welded structures dictates the approach taken in this research. The microstructural observations on the different zones of the weld seam indicates that the variation of heterogeneous structure is a progressive destruction of the strips of lamination which cause a new phase leading to a drop in the mechanical properties requiring treatment after welding. The fatigue cracking rate diverges beyond the threshold of DK, but no deviation of the crack from its propagation axis was noticed, which confirms the correct choice of filler metal over that of the base metal with an overmatching M = 1.1, and the treatments applied to the structure. This fatigue cracking rate transversal to the welding direction initially presents an aspect similar to that of BM but registers a delay as soon as the crack tip enters the second zone (HAZ) then it progresses rapidly. This evolution is characterized by a disturbance due to the repeated change of microstructure.
Experimental study of the Portevin-Le Chatelier effect under complex loading of Al-Mg alloy: procedure issues
Authors: Tretyakova Tatyana Viсtorovna , Tretyakov Mikhail , Chechulina Evgeniia
Published: October 2021

The aim of this work is to solve the methodological issues of the experimental study of the nucleation and propagation of deformation bands due to the Portevin-Le Chatelier effect under conditions of complex loading. It is of interest to determine the boundaries of unstable plastic deformation of the AMg6 alloy under complex loading conditions. A technique for controlling the loading process with a given rate of deformation intensity of materials has been worked out. The results showed that short-term stops and unloading during loading influence on the value of critical deformation, at which the manifestation of the jerky flow begins. The evolution of inhomogeneous strain fields and local strain rates under conditions of manifestation of jerky flow during tension with torsion tests of Al-Mg alloy samples.
On Ideal Convergent Difference Double Sequence Spaces in Intuitionistic Fuzzy Normed Linear Spaces
Authors: KAMBER Esra , ALTUNDAĞ Selma
Published: October 2021

In this paper, we introduce difference double sequence spaces ${I_{2} }^{(\mu,\upsilon)}(M,\Delta)$ and ${I_{2}^{0}}^{(\mu,\upsilon)}(M,\Delta)$ in the intuitionistic fuzzy normed linear spaces. We also investigate some topological properties of these spaces.
The effects of plasma viscosity in thromboembolic events among patients with essential thrombocytosis: A case-control study
Authors: Güney Tekin , Can Ferda , Alkan Afra , Akıncı Sema , Dilek İmdat
Published: October 2021

INTRODUCTION:

Essential thrombocythemia (ET) is an entity of classic Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs), characterized by thrombocytosis with megakaryocytic hyperplasia where in the thrombocytes are increased with abnormal function. Thrombotic events are seen frequently and represent the main cause of morbidity and mortality in patients with MPNs, mainly polycythemia vera and ET. This study has aimed to research the effects of clonally increased thrombocytes on plasma viscosity (PV) levels among patients with ET and the relationship between PV and thromboembolism history, according to the hypotheses about the effects of PV in thromboembolic events among patients with ET.

METHODS:

A total of 55 patients were enrolled in the study group, 18 of who had been newly diagnosed with ET according to 2016 World Health Organization criteria and had not previously been treated. 37 of them had already been diagnosed with ET and had been treated. There were 47 healthy volunteers in the control group. 5 cc blood samples were taken from the patients into tubes including an anticoagulant to measure their PV levels.

RESULTS:

PV of the control group was found to be lower than in the study group and both each patient groups ( p < 0.05). No relationship was found between the patient groups in terms of PV ( p = 0.404). The mean PV levels of the 16 patients with a history of thromboembolism and the 39 patients with no such history were 2.42±0.17 cP and 2.33±0.20 cP, respectively. The mean PV levels were found to be similar according to their history of thromboembolism in all patient groups and in treated patients ( p = 0.572 vs p = 0.991).

CONCLUSION:

We have found that PV levels were increased in clonally increased thrombocytes in patients with ET when compared with the control group. This is the first study in this field according to our knowledge.
Soundness Verification of Data-Aware Process Models with Variable-to-Variable Conditions
Authors: Felli Paolo , de Leoni Massimiliano , Montali Marco
Published: October 2021

Traditionally Business Process Modeling has only focused on the control-flow perspective, thus allowing process designers to specify the constraints on the activities of the process: the order and potential concurrency of their execution, their mutual exclusivity, the possibility of being repeated, etc. However, activities are executed by different resources, manipulate data objects and are constrained by the state of such objects. This requires that the traditional notion of soundness, typically introduced for control-flow-only models, is extended so as to consider data. Intuitively, a (data-aware) process model is sound if (1) it does not contain deadlocks, (2) no more activities are enabled when the process instance is marked as completed and finally (3) there are no parts of the model that cannot be executed. Although several data-aware notations have been introduced in the literature, not all of these are given a formal semantics. In this paper, we propose a technique for checking the data-aware soundness for a specific class of such integrated models, with a simple syntax and semantics, building on Data Petri Nets (DPNs). These are Petri nets enriched with case variables, where transitions are guarded by formulas that inspect and update such variables, and are of the form variable-operator-variable or variable-operator-constant. Even though DPNs are less expressive than Petri nets where data are carried by tokens, they elegantly capture business processes operating over simple case data, allowing to model complex data-aware decisions. We show that, if a DPN is data-aware sound, the Constraint Graph is a finite-state automaton; however, a finite-state Constraint Graph does not guarantee data-aware soundness, but provides a finite structure through which this property can be checked. Finally, we investigate further properties beyond data-aware soundness, such as the problem of verifying that an actor participating in the business process can unilaterally enforce data-aware soundness by restricting the possible executions of a bounded DPN, assuming this actor to be able to control the firing of some transitions and decide the value of some of the case variables whenever these are updated.
KNN Loss and Deep KNN
Authors: Le Linh , Xie Ying , Raghavan Vijay V.
Published: October 2021

The k Nearest Neighbor (KNN) algorithm has been widely applied in various supervised learning tasks due to its simplicity and effectiveness. However, the quality of KNN decision making is directly affected by the quality of the neighborhoods in the modeling space. Efforts have been made to map data to a better feature space either implicitly with kernel functions, or explicitly through learning linear or nonlinear transformations. However, all these methods use pre-determined distance or similarity functions, which may limit their learning capacity. In this paper, we present two loss functions, namely KNN Loss and Fuzzy KNN Loss, to quantify the quality of neighborhoods formed by KNN with respect to supervised learning, such that minimizing the loss function on the training data leads to maximizing KNN decision accuracy on the training data. We further present a deep learning strategy that is able to learn, by minimizing KNN loss, pairwise similarities of data that implicitly maps data to a feature space where the quality of KNN neighborhoods is optimized. Experimental results show that this deep learning strategy (denoted as Deep KNN) outperforms state-of-the-art supervised learning methods on multiple benchmark data sets.
Inhibitory Fcγ Receptor and Paired Immunoglobulin Type 2 Receptor Alpha Genotypes in Alzheimer’s Disease
Authors: Pandey Janardan P. , Namboodiri Aryan M. , Nietert Paul J. , Barnes Lisa L. , Bennett David A.
Published: October 2021

We investigated whether FCGRIIB (rs1050501 C/T) and PILRA (rs1859788 A/G) genotypes contributed to the development of Alzheimer’s disease (AD). We genotyped 209 African American (AA) and 638 European American (EA) participants for the FCGRIIB and PILRA alleles. In the AA cohort, subjects homozygous for the C allele of FCGRIIB were more than 4 times as likely to develop AD as those homozygous for the alternative T allele. This SNP also interacted with PILRA: participants who were the carriers of the FCGRIIB C allele and PILRA A allele were 3 times as likely to develop AD as those who lacked these alleles.
EVALUATION OF THE THERAPEUTIC EFFECT OF THE COMBINED USE OF CRYOPRESERVED PLACENTA EXTRACT AND DICLOFENAC SODIUM IN EXPERIMENTAL RHEUMATOID ARTHRITIS BY HEMATOLOGICAL PARAMETERS
Authors: Hladkykh F. V.
Published: October 2021

Relevance. Cryopreserved placenta extract (CPE) increase the resistance of the mucous membrane of the gastrointestinal tract to the damaging effects of nonsteroidal anti-inflammatory drugs. Preventive administration of CPE can reduce the ulcerogenic effect of meloxicam, ibuprofen, diclofenac sodium (DS) and others. There is evidence of CPE's own anti-inflammatory activity, which can be successfully combined with the pharmacological properties of nonsteroidal anti-inflammatory drugs, while improving their safety profile.

Objective: to characterize the therapeutic activity of the combined use of CPE and DS according to hematological parameters in the model of experimental rheumatoid arthritis (RA).

Materials and methods. Studies were performed on 28 nonlinear laboratory rats. The rats were divided into 4 groups: I (n = 7) – intact rats; II (n = 7) – rats with experimental RA; ІІІ (n = 7) – rats with experimental RA, treated with DN; IV (n = 7) – rats with experimental RA, treated with DN and CPE. Adjuvant arthritis was modeled by subplantar administration of complete Freund's adjuvant. Treatment was performed from 14 to 28 days. CPE was administered on days 14, 17, 20, 23 and 26, and DS – daily. Blood tests were performed on day 28 of the experiment.

Results. The combined use of CPE and DS is accompanied by a more pronounced leveling of inflammatory signs by hematological parameters – erythrocyte clotting rate decreased by 72.2% (p<0.001), and the number of leukocytes decreased by 54.81% (p<0.001) relative to rats with adjuvant arthritis without treatment. There was a leveling of signs of anemia of chronic inflammation – the level of hemoglobin and erythrocytes increased (p<0,001) by 17.6% and 36.8%, respectively, relative to rats with adjuvant arthritis without treatment.

Conclusions. The combined use of CPE and DS is superior in therapeutic activity to monotherapy with this nonsteroidal anti-inflammatory drug of experimental rheumatoid arthritis.
PROPHYLACTIC EFFECT OF A PROBIOTIC INTERVENTION IN CHILDREN PRONE TO ACUTE UPPER RESPIRATORY TRACT INFECTIONS: A RANDOMIZED CONTROLLED TRIAL
Authors: Marushko Y.V. , Hyshchak T.V. , Todyka Y.I.
Published: October 2021

Relevance. Upper respiratory tract infections (URTIs) are common in children and often progress with secondary complications such as otitis media, bronchitis, or pneumonia, especially in children with recurrent URTIs. Probiotics displayed immunomodulatory effects in children and adults, supporting immune functions to prevent winter diseases or common colds.

Objectives. We assessed the effectiveness of a 6-week prophylaxis with probiotics (Lactobacillus helveticus Rosell®-52, Bifidobacterium infantis Rosell®-33 and Bifidobacterium bifidum Rosell®-71) for preventing primary infections and/or secondary complications in URTI-prone children.

Methods. URTI-prone children were randomly divided into the probiotics (3×109 CFU/day; 6 weeks) or control arm (no preventive intervention). The number of URTIs, duration and related complications were monitored for 6 months. Resistance index, number of medical visits, and antibiotics prescriptions were also recorded.

Results. After 2 months, probiotics reduced the number of URTIs (-2.34±0.13 vs -0.24±0.14; P<0.0001) and duration in (-1.13 ±0.18 vs -0.18±0.18 days; P=0.0011), and the number of secondary complications (-53% vs -5.8%; RR 0.5313 95% CI [0.3534, 0.7986] P= 0.0058). Probiotic lowered resistance index (P<0.0001), number of medical consultations with specialized physicians (P=0.0033) and antibiotics prescriptions (P<0.0001).

Conclusions. Overall, a 6-week prophylaxis with combined probiotic (Lactobacillus helveticus Rosell®-52, Bifidobacterium infantis Rosell®-33 and Bifidobacterium bifidum Rosell®-71) in URTI-prone children exerted a significant and clinically important health benefit, decreasing the number and duration of URTI episodes and secondary complications and reducing the resistance index to a near-normal value. Furthermore, potential societal benefits of reducing health care use and inadequate antibiotic prescriptions in children favours the use of this probiotic product as a preventive strategy against URTIs and their consequences in frequently sick children.

This trial was retrospectively registered on ClinicalTrials.gov (NCT04525040).
Covid-19 : Natural immunity versus vaccine immunity
Authors: Banoun Helene
Published: October 2021

It should not be necessary to write an article to demonstrate the superiority of natural immunity over vaccine immunity, but it is necessary in view of the many underhanded attacks that tend to make artificial immunity seem more effective. Furthermore, it is officially recommended to vaccinate people who have already been infected with Covid-19.
Survivors of the 2003 SARS-CoV have cellular immune memory more than 17 years after infection.
Numerous studies have explored humoral (antibody) and cellular immunity to SARS-CoV-2 after Covid-19 infection: it persists for at least one year (and even 14 months) in a robust manner in convalescents and would be of better quality than vaccine immunity: natural antibodies are more potent, have a broader spectrum, and are able to evolve against variants more efficiently than vaccine antibodies.
These _in vitro _studies are confirmed by the protection against reinfections conferred by a primary infection, particularly in early and highly vaccinated countries such as Israel and the United Kingdom.
Vaccination of a primo-infected person could also decrease the effectiveness of his natural immunity against future reinfections.
Neutralizing antibodies may not be the correct correlate of protection against infection, as high levels of neutralizing antibodies have been found in patients with severe Covid, and vaccinated patients, who are more susceptible to reinfection than primary patients, have antibody levels equivalent to or higher than those observed in primary patients.
The neutralizing capacity of these antibodies directed against the membrane spike protein is measured _in vitro_. This neutralizing capacity may be different _in vivo_; it may be diminished by the presence of antibodies that facilitate infection; and antibodies are produced against other viral antigens during natural infection. Cellular immunity could be the right correlate of protection and this type of response could be of lower quality in vaccinated subjects.
In addition, vaccination of convalescent subjects could be risky: more systemic adverse events are observed in convalescent subjects than in naïve subjects after the first dose of vaccine.
Vaccination may decrease the ability to respond to future variants. It could also have a non- specific effect of remodeling the innate immune response by decreasing the potential response to other viruses or cancers and by modifying the course of inflammatory and autoimmune diseases.
The natural immunity of a population should therefore be explored before proposing vaccination: up to 50% of the population may have been infected in some countries.
Effects of brachytherapy on cytogenetic parameters and oxidative status in peripheral blood lymphocytes of gynecologic cancer patients
Authors: Ivankova V.S. , Domina E.A. , Khrulenko T.V. , Makovetska L.I. , Hrinchenko O.O. , Baranovska L.M.
Published: October 2021

Summary. Background: The state-of-the-art brachytherapy technologies with high-dose sources of 60Co and 192Ir within contemporary treatment protocols for cancer patients allow achieving maximum dose distribution in the clinical target and with minimum radiation exposure of surrounding organs and tissues. For minimization and overcoming the early and late radiation complications, development of respective radiobiological criteria along with perfecting of physical and technical characteristics of the ionizing radiation sources are required. Aim: To study the effect of 192Ir radiation on the chromosomal aberrations and prooxidant/antioxidant status of blood lymphocytes in gynecological cancer patients. Materials and Methods: The patients (n = 45) with endometrial, cervical and secondary cancer of vagina were enrolled in the study. For brachytherapy, the irradiation of vaginal mucosa was conducted using “GammaMed plus” device for contact radiation therapy with 192Ir source. Prior to irradiation and in 20–24 h after brachytherapy session, the venous blood samples were obtained and peripheral blood lymphocytes (PBL) were cultured for cytogenetic analysis. The prooxidant/antioxidant status was determined in hemolysates by the method of hydrogen peroxide-induced chemiluminescence. Results: The average level of spontaneous chromosome aberrations in PBL of the patients was (7.8 ± 0.4) per 100 metaphases, which is more than twice higher than the upper limit of the average population values. The frequency of chromosome aberrations in PBL of patients after brachytherapy session was (15.3 ± 1.0) per 100 metaphases. An increased intensity of O2- generation by PBL after brachytherapy session was also noticed. Conclusion: Local irradiation at a dose of 6 Gy featuring the first dose fraction of brachytherapy induces extra chromosomal aberrations in PBL of gynecological cancer patients and intensifies prooxidant processes in the blood.
Evaluation of serum levels of selected cytokine receptors in adult B-cell precursor acute lymphoblastic leukemia and their association with prognostic factors and survival
Authors: Horacek J.M. , Kupsa T. , Vanek J. , Jakl M. , Stajer M. , Jebavy L. , Zak P.
Published: October 2021

Summary. Aim: To evaluate serum levels of selected cytokine receptors in B-cell precursor acute lymphoblastic leukemia (B-ALL) and their association with acknowledged prognostic factors, relapse-free survival (RFS) and overall survival (OS). Materials and Methods: A total of 42 de novo adult B-ALL patients, 19 BCR/ABL positive, were included in this study. Soluble receptor α for IL-2 (sIL-2Rα), soluble receptor for IL-6 (sIL-6R), soluble receptor for TNF-α type I and II (sTNFR-1, sTNFR-2) and matrix metalloproteinase-9 (MMP-9) were measured by biochip array technology at diagnosis and in complete remission (CR). Results: At diagnosis of B-ALL, we found significantly higher levels of sIL-2Rα, sIL-6R, sTNFR-1, sTNFR-2 and significantly lower levels MMP-9 in comparison with CR (p < 0.001 in all cases). BCR/ABL positive patients had higher levels of sIL-2Rα at diagnosis (r = 0.484; p = 0.014). Serum levels of evaluated cytokines were not associated with achievement of CR after one cycle of induction therapy, RFS or OS. Conclusion: Serum levels of all evaluated cytokines are significantly altered in newly diagnosed B-ALL reflecting activity of the disease. No significant correlations with response to first induction therapy, RFS or OS were found. Further studies with a longer follow-up will be needed.
Experimental substantiation of the use of hydroxyapatite — tricalcium phosphate bioceramics for replacing bone defects after tumor removal
Authors: Konovalenko V.F. , Ternovyi N.K. , Tuz E.V. , Protsenko V.V. , Solonitsyn E.O. , Audai A. , Drobotun O.V. , Ulianchych N.V.
Published: October 2021

Summary. Background: Recently, bioactive ceramics based on hydroxyapatite (HAP) and tricalcium phosphate (TCP) have been preferred as implants in bone engineering. Aim: To study bone regeneration under conditions of filling metaphyseal defects with the original HAP-TCP composition. Materials and Methods: The experiment was carried out on inbred rats, the observation period was 2, 4, 8 weeks. Morphological studies were carried out using light and electron microscopy. Results: In the dynamics of observation at 2, 4 and 8 weeks, a gradual arrangement of osteoclasts and osteoblasts on the surface of HAP-TCP was recorded, which indicates its high biocompatibility with bone tissue. During the experiment, the processes of resorption of implants, mineralization, proliferation of cellular elements of collagen and osteogenesis (osteoblasts and osteoclasts) and the formation of mature bone tissue were recorded. Conclusions. Experimental studies of plastic bone defects proved the presence of the osteoinductive and osteointegrative effect of HAP-TCP composition, which contributes to a more dynamic uncomplicated course of reparative osteogenesis.
Highly Nonlinear Solitary Waves to Estimate Orientation and Degree of Anisotropy in Rocks
Authors: Jalali Hoda , Zeng Yuhui , Rizzo Piervincenzo , Bunger Andrew
Published: October 2021

This paper delves into the use of highly nonlinear solitary waves for the nondestructive identification and characterization of anisotropy in rocks. The nondestructive testing approach proposed expands upon a technique developed recently by some of the authors for the nondestructive characterization of engineering materials and structures. The technique uses the characteristics of solitary waves propagating in a periodic array of spherical particles in contact with the rock to be characterized. The features of the waves that bounce off the chain rock interface are used to infer some properties of the geomaterial under consideration. Numerical models and experimental validation were conducted to explore the feasibility of the method and to standardize the methodology for future widespread applications.
Understanding Eddy Current Array for High-Performance Inspections
Authors: Allard Anne-Marie , Grenier Marc , Sirois Michael , Wassink Casper
Published: October 2021

Eddy current testing (ECT) has been used for quite a while now and has been proven a reliable surface inspection technique for conductive materials. In the last 15 to 20 years, this technique has evolved toward the use of eddy current arrays (ECAs), and many applications can now benefit from this configuration to improve data quality, inspection speed, and ease of deployment, and considerably reduce operator dependency. The physics principle behind ECT and ECA is the same and was addressed in a previous issue of Materials Evaluation (Wassink et al. 2021). In this paper, we will discuss the main differences between ECT and ECA as well as how the arrangement of coils in an array can allow for optimized detection capabilities on different materials or types of defects. Common applications where ECA has demonstrated its strength will also be discussed.
Câncer Gástrico em Adultos Jovens
Authors: Mauad Edmundo Carvalho , Nogueira Jarbas Leite , Souza José Maria Pacheco de , Wohnrath Durval Renato , Oliveira Antonio Talvane Torres de , Colli Gilberto , Costa Aluyzio de Mendonça
Published: October 2021

Estudos realizados em outros países relatam que menos de 5% dos casos de câncer gástrico ocorrem em pessoas com menos de 40 anos, faixa etária em que não é comum suspeitar-se desse diagnóstico. O propósito deste estudo foi avaliar os aspectos clínicos e a sobrevida de câncer gástrico em menores de 40 anos. Um estudo retrospectivo no período de 1970 a 1996 foi realizado no Hospital S. Judas Tadeu, Barretos, SP, utilizando os prontuários de 37 (4,9%) pacientes na faixa etária acima. Estadiamento utilizado: TNM (UICC/ União Internacional Contra o Câncer)); programa de computação Stata para fazer a análise multivariada, segundo o modelo de Cox, e a análise de sobrevida segundo o método Kaplan-Meier. Dos 37 pacientes, 81,1% tinham idade de 30 a 39 anos e 18,9% de 20 a 29 anos, e 54,3% eram do sexo masculino. Os sintomas mais comuns foram nessa ordem: dor epigástrica, vômitos, emagrecimento, plenitude pós prandial e astenia. Estadiamento: EC I: 3 pacientes; EC II: 3 pacientes; EC III: 11 pacientes; EC IV: 18 pacientes e em 2 pacientes o estádio não pode ser determinado. A sobrevida média foi de 561 dias, variando de 3 a 3736 dias. Foi encontrada uma diferença significativa (p<0,005) na comparação da sobrevida entre os pacientes com estádios I e II e os com estádios III e IV. Todos os pacientes com diagnóstico inicial I e II estão vivos e os demais foram ao óbito, em média 9 meses após o diagnóstico.
Administración Pública Electrónica: Un modelo para las parroquias rurales de Carchi
Authors: Almeida Burbano Diego Guillermo
Published: October 2021

Los procesos de transformación tecnológica y social en que hoy está inmersa la sociedad y, por ende, sus instituciones han generado una nueva forma de ver y entender la acción de las organizaciones gubernamentales. De hecho, dentro de este movimiento de modernización administrativa es urgente que los gobiernos locales, en específico las juntas parroquiales del Carchi, inserten en su accionar el uso de herramientas tecnológicas para la prestación de más y mejores servicios públicos. La presente investigación es resultado del proyecto de investigación denominado “Diseño de un modelo integrado de Administración Pública Electrónica aplicable en las parroquias de la provincial del Carchi, casos de estudio: Julio Andrade, Tufiño, Cristóbal Colón, Fernández Salvador, García Moreno, Los Andes, Mariscal Sucre, La Libertad, San Isidro, La Concepción y Juan Montalvo.” Dicho proyecto ha sido ejecutado por un equipo de docentes y estudiantes investigadores de la carrera de Administración Pública de la Universidad Politécnica Estatal de Carchi. Esta investigación se enfocó en el estudio de once juntas parroquiales de la provincia de Carchi, lo que nos permitió visualizar un panorama de la realidad administrativa de los gobiernos locales en territorio. La motivación esencial por la cual se presenta este trabajo parte de la necesidad imperante de mejorar nuestras administraciones públicas. Esto en virtud de que, como se pudo evidenciar en el trabajo de campoy en la realidad actual de nuestras instituciones, el uso de la tecnología mejora la calidad en los procesos y servicios públicos. A pesar de ello, sin embargo, no ha tenido el desarrollo e impacto significativo que la sociedad demanda.
Reflexões sobre os paradigmas baseados no conhecimento do senso comum e científico
Authors: Antunes Maria de Fatima Nunes , Guglielmi Juçara , Arcari Inedio
Published: October 2021

Na educação de um país são fundadas as primeiras bases da reflexão sobre paradigmas, sendo esta a primeira base de reflexão que extrapola as convicções da família. O estudante é então exposto a uma grande variedade de verdades, afirmações de diferentes culturas e modos de vida. Logo, com este artigo pretende tecer algumas reflexões sobre os paradigmas relacionados ao senso comum e a ciência, discutindo aspectos voltados ao ambiente vivenciado por professores e alunos de acordo com a literatura. O estudo baseou-se em uma pesquisa bibliográfica entrelaçando e discutindo a questão dos paradigmas, que no dia a dia da sala de aula são presenciados. Concluiu-se nessas reflexões que o modo tradicional de se apresentar a educação envolto de paradigmas, passa por algumas discussões que aos poucos tem provocado uma ruptura neste modo de educação, reconstruindo assim, novos paradigmas.
PECULIARITIES OF MATERIAL RESOURCE MANAGEMENT OF ENTERPRISES OF BUILDING MATERIALS
Authors: Hobyr Iryna , Hobyr Lidiia
Published: October 2021

In a market economy, it becomes important to improve the organization of enterprise management and, above all, the production process, efficient use of financial, material resources and inventories. Effective management of material resources increases profits and provides the necessary investment. To maintain high profitability and liquidity, the management of current activities of enterprises, in particular inventory management plays a significant role. The categorical apparatus of material resources management at the enterprise is considered, the definition of “material resources” is generalized, the definition of "material resources management" is offered, and also the system of material resources management at the enterprise is considered. In the management of material resources at the enterprise there are 2 approaches – logistics and reengineering. The main tasks of the mechanism of management of material resources of the enterprise of building materials are defined. These are: increasing the efficiency of material resources and choosing cheap sources of funding; introduction of new production, resource-saving technologies; minimization of costs for procurement, production and marketing activities; increasing the interest of employees of all services in the effective performance of their duties; product quality management.
The analysis of efficiency of use of material resources at the enterprises of building materials which has shown, that manufacture of production is rather material-intensive is carried out. This is evidenced by the share of material costs in the cost of work, and the value of the utilization factor of materials indicates the economical use of material resources in production. Reserves for improving the efficiency of material resources at construction materials enterprises have been identified. The ways of the most rational use of material resources of construction materials enterprises are offered, in particular it is improvement of a design and technology of manufacturing of products, introduction of more progressive norms of expenses of resources, use of substitute materials, and reduction of losses at stages of transportation, storage and industrial use.
THE INFLUENCE OF MARKETING INSTRUMENTS ON THE FORMATION OF INVESTMENT ATTRACTIVENESS OF UNITED TERRITORIAL COMMUNITIES
Authors: Deineha Oleksandr , Deineha Inna
Published: October 2021

The article substantiates the expediency of using marketing tools to increase the investment attractiveness of the united territorial communities. Positive tendencies of creation and unification of territorial communities in Ukraine have been identified. This is primarily due to raising public awareness of the decentralization process, awareness of the positive results of the merger, including an increase in financial revenues from the state budget. Changes in the structure of state financing of local and regional development are studied. It is established that since 2017 the most important financial source for ensuring the development of territorial communities was the State Fund for Regional Development. Since 2016, a gradual increase in financial support by the state for infrastructure development, and in 2017 in the structure of state financial support there are funds for the construction of sports facilities and their share is growing steadily in 2018–2019. The specifics of the content of “state marketing” and “public marketing”. It is established that technological marketing in public administration does not differ significantly in essence from state marketing, but today it is more appropriate to use the term «marketing in public administration», which fully covers all subjects and objects of public administration, including territorial communities. The specific features of the marketing concept implementation in the activity of the united territorial communities have been identified. The components of the marketing complex of the united territorial communities are determined, in particular the goods, price, promotion, place, people, process, environment, i.e. the marketing of the united territorial community is carried out according to the principle “7p”, which is characteristic of marketing of all service organizations. The mechanism and key marketing tools for influencing the capacity of the united territorial communities have been identified. The essence of the concept of “investment attractiveness of the territorial community” is formed. The main tasks to be solved by the united territorial community in order to increase its own investment attractiveness have been identified.
RESEARCH OF LOGISTIC SYSTEM EFFICIENCY AT AGRICULTURAL ENTERPRISE
Authors: Mashchak Nataliia , Prokopenko Karyna
Published: October 2021

The article considers the current state and development trends of the agricultural sector of Ukraine, which is closely linked to natural conditions, resources, technical capabilities and skilled professionals, is one of the main budget-generating areas of the economy and ranks second in the commodity structure of exports. Based on the analysis, the positive and negative factors influencing the development of the agricultural sector are identified; the resource potential and opportunities for further active development of the industry are assessed. The essence of the concept of agrologistics as an effective tool for improving the efficiency of agricultural enterprises, which will provide real opportunities for specialists and employees of the agricultural sector to focus on the organization of the appropriate level of logistics activities in agricultural enterprises, its effective implementation and further development. The activity of the domestic agrarian holding, which is engaged in the cultivation of grain crops (not including rice), legumes and oilseeds, is considered. The main problems of the logistics system of this agricultural enterprise by surveying employees for its efficiency and the presence of management problems are studied. The study identified a number of problems in the logistics system, including supply system failures, problems in information flow management, warehousing and storage of unused resources, difficulties in reverse logistics, which causes additional costs and reduces the efficiency of the holding. It is noted that the identified shortcomings and problems are the task of agro-logistics, which confirms the need and feasibility of its implementation in the activities of the agroholding to increase the efficiency of its logistics system and increase economic performance. This study emphasizes the need to use the basic principles and approaches of agrologistics in the production, processing, storage and transportation. Widespread use of agrologistics by domestic agricultural holdings will contribute to the formation of a successful agricultural policy of the country, which will strengthen their position domestically and internationally.
MARKETING INFORMATION SYSTEM IN THE CONDITIONS OF MODERN CONSUMPTION ECOSYSTEMS
Authors: Radchenko Hanna , Kazanska Olena , Khoroshykh Viktoriia
Published: October 2021

The article draws attention to the global nature of the pandemic, accelerating digitalization at an unprecedented rate, with online platforms playing an indispensable role in helping citizens transition to the new life realities in the pandemic and enabling them to lead their normal daily lives despite periodic blockages. In the next decade, a technological solutions wave will affect and transform almost every area of our lives. Technology can both solve existing problems and exacerbate them, as well as create new ones. It is important to shape a fair and responsible future in which we want to live and exist, because technology can scale both solutions and problems.
Marketing is an intermediate link in the information path between the enterprise and the consumer. If marketing with the help of appropriate methods and tools correctly interprets the features that characterize market processes, the market will receive consumer-oriented products. The article gives the author's definition of this term, as well as the trends in the such systems development and their ability to adapt to ever-changing conditions. It is determined that for the normal system existence it is necessary to implement an adaptive marketing information system that will resolve issues between the main system components: consumers, business structures and the state.
We can assume that the modern consumption ecosystem is an information and communication environment consisting of information and technical (artificially created by man - the world of technology, etc.) and information and psychological (the world of wildlife, which includes man himself) systems. In this case, as a supply system or service system can be considered just a marketing information system that helps the whole system to achieve a social goal, and in the case of modern ecosystems to ensure the normal functioning of all elements of the system.
It is concluded that it is necessary to implement an adaptive marketing information system for the normal system existence that will resolve issues between the main system components: consumers, business structures and the state. It is proved that such an information system will become the main core of a digital organization, and will be able to cover the providing solutions technology for staff, as well as managing the partner digital ecosystem and new models of administrative processes that it implements. The main functions of such a system include: the use of ready-made solutions that simplify the applications development and deployment; platform economy challenges and risks and the reaction of regulators.