bluuebunny/crossref_metadata_2025 huggingface dataset:
Liberalism in Devon and Cornwall, 1910–1931: ‘the old-time religion’
Authors: Dawson Michael
Published: May 2019

Liberalism in Devon and Cornwall before 1914 pursued a traditional ‘democratic’ rhetoric based on a class division which associated the Liberal party with ‘the people’ and Unionism with a privileged aristocracy. The ‘new Liberalism’ and social reform were unimportant. In the 1920s, the Gladstonian trinity of peace, retrenchment and free trade comprised easily the most common theme in Liberal candidates’ speeches. The Gladstonian tradition remained central to Liberalism because it accurately reflected the preoccupations of the party's core supporters in the region. There was apparently no belief amongst Liberals that the party's policies after 1918 were out-dated and irrelevant; their view is supported by an analysis of the 1923, 1924 and 1929 contests and their results.

Throughout the period, Liberal candidates were as ready and able as their opponents to use the coarser arts of electioneering. Liberalism was not wedded to a restricted Edwardian electorate with a relatively high level of political intelligence. The argument that it was is contradicted by contemporary accounts that the electorate of the 1920s was more thoughtful and less susceptible to emotional appeals than were pre-war voters.
Last Word
Authors: Callan Eamonn
Published: May 2019

What are the virtues that befit citizens of a liberal democracy? What moral constraints should the state respect in its sponsorship of political education? In “Political Liberalism and Political Education” I gave a partial answer to the first question; apart from a solitary footnote, I ignored the second. Yet some of my Rawls-inspired remarks about the connection between the burdens of judgment and toleration blurred the distinction between the two questions. That is unfortunate because the distinction matters.

Suppose we answer the first question correctly. We might still be tempted to pursue the ends of political education with Jacobin ferocity, laying waste to all that impedes our righteous cause. That course is subject to overwhelming moral criticism. Liberals must care about freedom of conscience and not just about the freedom of the virtuous liberal conscience. Alternatively, a correct answer to the second question might coincide with a certain blindness to the importance of the first or with a tendency to confound what is properly tolerated in a liberal democracy with what is rightly deemed virtuous. Liberals cannot afford to be indifferent to the virtues that are distinctive of the liberal conscience or to neglect the educational practices that would nourish them. If a self-defeating cultural aggressiveness is the vice of some who are fixated by the first question, an equally destructive cultural complacency is the besetting sin of those who take the second question seriously without having a credible answer to the first.
The Honecker Trial: The East German Past and the German Future
Authors: McAdams A. James
Published: May 2019

Fifty years after the Nuremberg tribunals, Germany is once again caught up in a series of controversial trials involving former dictators. This time, officials of the former German Democratic Republic (GDR) sit in the docks. Some observers have criticized these proceedings, maintaining that they will result in the imposition of an arbitrary form of “victor's justice.” Others have claimed, in contrast, that the cumbersome GermanRechtsstaat(“state under the law”) will prove incapable of responding to public demands for retribution. In this article, the author maintains that Germany's courts have not been at a loss in answering these complaints. By grounding their judgments in preexisting East German law, the courts have managed to bring some of the GDR's former leaders to justice while at the same time guaranteeing most defendants the full protection of the rule of law. In the process, the courts have even conveyed an important message about the terms under which both German populations will be brought back together again.
Inheritance of Dicamba Resistance in Wild Mustard (Brassica kaber)
Authors: Jasieniuk Marie , Morrison Ian N. , Brûlé-Babel Anita L.
Published: May 2019

The inheritance of resistance to dicamba in wild mustard was determined by making reciprocal crosses between a resistant (R) population derived from a field treated repeatedly with auxin-type herbicides, and a known susceptible (S) population. The resulting F1hybrids were selfed to produce F2populations and backcrossed to the S parent. At the three- to four-leaf stage, parental, F1, F2, and backcross populations were screened for resistance to dicamba at three dosages (50, 200, and 400 g ai ha−1). F1progeny survived all dosages and exhibited levels of injury similar to the R parental population. F2populations segregated in a 3:1 ratio of R to S phenotypes. Progeny of backcrosses segregated in a 1:1 (R:S) ratio. Responses of the F1, F2, and backcross populations to treatment with dicamba indicate that resistance is determined by a single, completely dominant nuclear allele.
Influences of Temperature, Light and Water Stress on Germination of Fringed Sage (Artemisia frigida)
Authors: Bai Yuguang , Romo James T. , Young James A.
Published: May 2019

Experiments were conducted to determine the influences of temperature, light, winter storage, and water stress on seed germination of fringed sage. Seeds collected in 3 yr in central Saskatchewan were placed in sealed vials and buried in the soil after harvest, and germination was tested in spring and early summer. Seeds germinated over a wide range of temperatures with alternating 25/15 C being optimal. The range of optimal temperatures was higher for older seeds than younger seeds. The stimulating effect of light on germination varied among collections and incubating temperatures. Total germination and germination rate was limited by water stress and no seeds germinated at osmotic potentials below −0.9 MPa. Seeds hydrated in the autumn and exposed to low winter temperatures had higher germination the following spring than dry seeds exposed to the same conditions. Results suggest that sufficient soil moisture combined with moderate seedbed temperatures are optimal for fringed sage germination. Periodicity of germination may be influenced by variable germination requirements in different aging seeds.
Weed Control and Herbicide Tolerance in a Common Vetch-Oat Intercrop
Authors: Caballero Rafael , Barro Carmen , Alzueta Carmen , Arauzo Mercedes , Hernaiz Pedro J.
Published: May 2019

Field studies were conducted over 3 yr in central Spain to investigate the tolerance of common vetch and oat to some preemergence herbicides and their effects on weed control, forage yields, and botanical composition of the forage mixture. Pendimethalin was the only herbicide that injured common vetch. Pronamide and pronamide plus diuron injured oat by affecting plant emergence. Prevalent weed species were fumitory, henbit, and wild buckwheat. All herbicides provided more than 90% control of fumitory and most herbicides except pronamide provided more than 90% control of henbit relative to the untreated check. Wild buckwheat stands were reduced by isoxaben (68%), linuron (40%), prometryn (69%), pronamide (86%), and pronamide plus diuron (61%). More than 90% control of prostrate knotweed was achieved with isoxaben, pronamide, and terbutryn. Pronamide and pronamide plus diuron reduced forage yields and increased vetch in the forage. The untreated vetch and oat monocrop treatments showed the competitive advantage of oat over vetch and weedy species.
Nicosulfuron and Primisulfuron Root Uptake, Translocation, and Inhibition of Acetolactate Synthase in Sugarbeet (Beta vulgaris)
Authors: Novosel Karen M. , Renner Karen A.
Published: May 2019

Field studies have shown primisulfuron to be more injurious to sugarbeet than nicosulfuron 1 and 2 yr after herbicide application. Experiments were initiated to determine if primisulfuron is more injurious to sugarbeet grown in a nutrient culture and if the difference in sugarbeet response is a result of greater uptake, translocation, or acetolactate synthase (ALS) site sensitivity with primisulfuron. Concentrations of primisulfuron and nicosulfuron that reduced sugarbeet growth by 50% were 1.9 and 8.9 μg ai L−1, respectively, at pH 6.5. The pH of the nutrient solution did not influence sugarbeet response to either herbicide. Uptake of primisulfuron was greater (3%) than that of nicosulfuron (1%). Translocation (expressed as a percent of uptake) of nicosulfuron was more rapid than primisulfuron. Fifty-seven percent of the absorbed nicosulfuron translocated out of the root during the 12-h pulse period, while an equal concentration of primisulfuron was not translocated out of the root until 48 h after pulsing. The total nicosulfuron translocated after 144 h was half that of primisulfuron. The nutrient solution taken up by sugarbeet in the 12-h pulse period was reduced by 41% in the presence of either herbicide compared to the untreated control. The ALS enzyme was a minimum of 15 times more sensitive to primisulfuron compared to nicosulfuron which may account for greater sugarbeet response to primisulfuron.
Uptake, Translocation, and Metabolism in Alfalfa (Medicago sativa) Selected for Enhanced Tolerance to Terbacil
Authors: Anderson Michael. P , Bensch Curtis , Stritzke Jimmy F. , Caddel John L.
Published: May 2019

Terbacil tolerance was investigated in field-selected alfalfa strain ‘OK 182.’ Growth response studies indicated a 78% increase in tolerance over the unselected parental cultivar ‘Cimarron.’ Photosynthetic electron transport was inhibited similarly in both cultivars when isolated thylakoids were exposed to a wide range of terbacil concentration indicating that tolerance was not due to reduced sensitivity at the site-of-action. ‘OK 182’ took up an average of 22% less14C-terbacil over the 6-d labeling period. A similar proportion of total radiolabel was translocated in both strains indicating that differential translocation was not a factor in the tolerance mechanism. Once in the leaves, terbacil was rapidly metabolized to a glucosidic conjugate by both strains. Terbacil and total concentration of metabolites in leaf tissues were 17% and 33% lower in ‘OK 182’ than in ‘Cimarron,’ respectively. Enhanced tolerance to terbacil in ‘OK 182’ was attributed to decreased terbacil uptake.
Round-leaved Mallow (Malva pusilla) Interference in Spring Wheat (Triticum aestivum) and Lentil (Lens culinaris) in Saskatchewan
Authors: Makowski Roberte M. D.
Published: May 2019

The competitive ability of annual round-leaved mallow was determined in spring wheat and lentil at Indian Head and Regina, Saskatchewan, in 1985 and 1986 using paired quadrats. Significant biomass and seed yield loss occurred in three of four tests in lentil and two of three tests in spring wheat. Differences in numbers of wheat tillers produced between weedy and weed-free plots were found in three of four tests. A two-variable model comprised of early season crop density loss and round-leaved mallow biomass best accounted for the majority of variation in crop yield loss for both lentil and wheat, and tiller density loss in wheat. In 1985 at Indian Head, where no yield loss occurred for either wheat or lentil, round-leaved mallow had been seeded immediately before the crop. Greater yield losses occurred at Regina, in the presence of an older, well-established infestation. In the years and locations with the greatest crop yield losses, round-leaved mallow emerged before the crop causing poor crop emergence. At Regina in 1986, crop yield losses were more than 60% in wheat and 90 to 100% in lentil because of large differences in crop density between weed-free and weedy subplots. Round-leaved mallow exhibited great variability in growth, producing more biomass per plant, more capsules per plant, and more capsules per gram of biomass in the less competitive crop, lentil, than in wheat. Density and biomass of round-leaved mallow were not correlated; with a density of 200 plants m−2, round-leaved mallow biomass in wheat ranged from 100 to 500 g m−2; while in lentil, from 200 to as high as 1000 g m−2, approximately double the range found in wheat. The type of round-leaved mallow infestation (newly seeded or well-established) and environmental conditions (mainly early season precipitation) account for differences between sites and between years.
Alternaria helianthiand Imazaquin for Control of Imazaquin Susceptible and Resistant Cocklebur (Xanthium strumarium) Biotypes
Authors: Abbas Hamed K. , Barrentine William L.
Published: May 2019

The efficacy ofAlternaria helianthion imazaquin-susceptible and -resistant biotypes of common cocklebur was evaluated with and without imazaquin.A. helianthicaused severe damage to both biotypes when applied at 80,000 conidia ml−1at the five- to six-leaf stage. Symptoms included necrotic lesions, stunting, and mortality. Mortality from imazaquin at 140 g ai ha−1was 0 and 100% and mortality fromA. helianthiat 80,000 conidia ml−1was 33 to 75% and 67 to 100% for resistant and susceptible biotypes, respectively, and surviving plants showed reduction in height, dry weight, and number of new leaves. The combination of imazaquin at 18 g ai ha−1andA. helianthiat 40,000 conidia ml−1was not synergistic or antagonistic in killing common cocklebur.
Palweed:Wheat: A Bioeconomic Decision Model for Postemergence Weed Management in Winter Wheat (Triticum aestivum)
Authors: Kwon Tae-Jin , Young Douglas L. , Young Frank L. , Boerboom Chris M.
Published: May 2019

Based on six years of data from a field experiment near Pullman, WA, a bioeconomic decision model was developed to annually estimate the optimal post-emergence herbicide types and rates to control multiple weed species in winter wheat under various tillage systems and crop rotations. The model name, PALWEED:WHEAT, signifies a Washington-Idaho Palouse region weed management model for winter wheat The model consists of linear preharvest weed density functions, a nonlinear yield response function, and a profit function. Preharvest weed density functions were estimated for four weed groups: summer annual grasses, winter annual grasses, summer annual broadleaves, and winter annual broadleaves. A single aggregated weed competition index was developed from the four density functions for use functions for use in the yield model. A yield model containing a logistic damage function performed better than a model containing a rectangular hyperbolic damage function. Herbicides were grouped into three categories: preplant nonselective, postemergence broadleaf, and postemergence grass. PALWEED:WHEAT was applied to average conditions of the 6-yr experiment to predict herbicide treatments that maximized profit. In comparison to average treatment rates in the 6-yr experiment, the bioeconomic decision model recommended less postemergence herbicide. The weed management recommendations of PALWEED:WHEAT behaved as expected by agronomic and economic theory in response to changes in assumed weed populations, herbicide costs, crop prices, and possible restrictions on herbicide application rates.
Productivity and Intraspecific Competitive Ability of a Velvetleaf (Abutilon theophrasti) Biotype Resistant to Atrazine
Authors: Gray James A. , Stoltenberg David E. , Balke Nelson E.
Published: May 2019

Studies were conducted to determine the relative competitive ability and productivity of an atrazine-resistant biotype (WRB1) and an atrazine-susceptible accession (WSA1) of velvetleaf from Wisconsin. Noncompetitive productivity studies conducted in the field and greenhouse during 1992 and 1993 showed that instantaneous relative growth rate, net assimilation rate, and leaf area ratio of the WRB1 biotype and WSA1 accession were similar. There were no consistent differences between the WRB1 biotype and WSA1 accession in plant height, shoot dry biomass, and leaf area over time. The WRB1 biotype and WSA1 accession did not differ in noncompetitive seed yield. A replacement series experiment conducted in the field in 1992 and 1993 showed that the WRB1 biotype and WSA1 accession did not differ in shoot dry biomass or seed yield at densities of 36, 64, and 100 plants m−2. Results suggest that resistance to atrazine has not reduced the noncompetitive productivity or the intraspecific competitive ability of the WRB1 biotype relative to the WSA1 accession. Thus, even in the absence of atrazine selection intensity, the frequency of atrazine resistance gene(s) is unlikely to decrease in the velvetleaf population from which the WRB1 biotype was selected.
Effects of Rotational Crop Herbicides on Rice (Oryza sativa)
Authors: Johnson David H. , Beaty J. Dwayne , Horton Diana K. , Talbert Ronald E. , Guy Charles B. , Mattice John D. , Lavy Terry L. , Smith Roy J.
Published: May 2019

Experiments were conducted from 1989 to 1991 on two silt loam and two clay soils to determine the effect of herbicides applied to the previous crop on growth and yield of rice. All herbicides were applied preplant-incorporated at recommended rates adjusted as needed for soil texture. Rice was planted the following year. Imazaquin, imazethapyr, alachlor, metolachlor, clomazone, trifluralin, and atrazine did not injure rice the year following application. Norflurazon was the only herbicide to injure rice on silt loam soils, with injury at one silt loam location in one of two years. Norflurazon and fluometuron residues caused rice injury on clay soils, and chlorimuron residues caused injury in one year on a day soil. This chlorimuron carryover injury was from August-planted soybean but did not occur from June-planted soybean. Norflurazon, fluometuron, and chlorimuron temporarily reduced rice dry matter early in the season. No herbicide reduced either rough rice or percent head rice yield on any of the soils.
Sugarcane (Saccharumspp.) Response to Simulated Fluazifop-P Drift
Authors: Richard Edward P.
Published: May 2019

The impact of POST applications of fluazifop-P on sugarcane grown in Louisiana was determined for 3, 6,11, 22, and 44% of the lowest rate recommended for the control of johnsongrass in soybean (100 g ai ha−1). In field studies, sugarcane injury 4 WAT increased as the rate of fluazifop-P increased. Injury in excess of 80% was observed when fluazifop-P at 44 g ha−1was applied in May and June and 54% when applied in August Sugarcane stalks treated with fluazifop-P were fewer in number, shorter and lighter, and immature at harvest This resulted in lower Brix and sucrose levels, higher fiber content, and ultimately lower sugar yields. Reductions in sugar yields associated with an application of fluazifop-P closely paralleled visual injury 4 WAT. Injury from application of fluazifop-P was also evident in the subsequent ratoon crop where reductions in spring shoot counts of 14 to 25% were obtained even when fluazifop-P had been applied at 6 g ha−1the previous year. Greenhouse studies indicated that the response observed in the field with CP 70-321 sugarcane was indicative of the major cultivars grown, with the possible exception of CP 74-383.
Decision Rules for Postemergence Control of Pigweed (Amaranthusspp.) in Soybean (Glycine max)
Authors: Dieleman Anita , Hamill Allan S. , Fox Glenn C. , Swanton Clarence J.
Published: May 2019

Weed control decision rules were derived for the application of postemergence herbicides to control pigweed species in soybean. Field experiments were conducted at two locations in 1992 and 1993 to evaluate soybean-pigweed interference. A damage function was determined that related yield loss to time of pigweed emergence, density, and soybean weed-free yield. A control function described pigweed species response to variable doses of imazethapyr and thifensulfuron. The integration of these two functions formed the basis of an economic model used to derive two weed control decision rules, the biologist's “threshold weed density” and the economist's “optimal dose.” Time of weed emergence had a more significant role than weed density in the economic model. Later-emerging pigweed caused less yield loss and therefore, decision rules lead to overuse of herbicides if emergence time is not considered. The selected herbicide dose influenced the outcome of the control function. Depending on the desired level of weed control, a herbicide could be chosen to either eradicate the escaped weed species (label or biologically-effective doses) or reduce the growth of the weed species and thereby offset interference (optimal dose). The development of a biologically-effective dose by weed species matrix was recommended. Decision rules should not be utilized as an exclusive weed management strategy but rather as a component of an integrated weed management program.
Weed Control With Reduced Rates of Four Soil Applied Soybean Herbicides
Authors: Muyonga Kilwake C. , Defelice Michael S. , Sims Barry D.
Published: May 2019

Field studies were conducted at two locations in Missouri in 1990 and 1991 to evaluate control of velvetleaf, ivyleaf morningglory, and cocklebur in soybean with label rates (1×) or reduced rates (0.5×) of four PPI herbicides followed with or without cultivation and POST application of one fourth (0.25×) the label rate of imazethapyr. Weed control and soybean yield with the 0.5× rate of preplant clomazone, imazaquin, metribuzin, and metribuzin + chlorimuron followed by either cultivation or imazethapyr POST was equivalent to a 1× rate of the PPI herbicides followed by either cultivation or imazethapyr. Weed control and soybean yield with the 0.5× rates of the PPI herbicides without cultivation or POST imazethapyr were lower than with 1× rates of PPI herbicides.
The Evolution and Genetics of Herbicide Resistance in Weeds
Authors: Jasieniuk Marie , Brûlé-Babel Anita L. , Morrison Ian N.
Published: May 2019

The importance of various factors influencing the evolution of herbicide resistance in weeds is critically examined using population genetic models. The factors include gene mutation, initial frequency of resistance alleles, inheritance, weed fitness in the presence and absence of herbicide, mating system, and gene flow. Where weed infestations are heavy, the probability of selecting for resistance can be high even when the rate of mutation is low. Subsequent to the occurrence of a resistant mutant, repeated treatments with herbicides having the same mode of action can lead to the rapid evolution of a predominantly resistant population. At a given herbicide selection intensity, the initial frequency of resistance alleles determines the number of generations required to reach a specific frequency of resistant plants. The initial frequency of resistance alleles has a greater influence on the evolutionary process when herbicides impose weak selection, as opposed to very strong selection. Under selection, dominant resistance alleles increase in frequency more rapidly than recessive alleles in random mating or highly outcrossing weed populations. In highly self-fertilizing species, dominant and recessive resistance alleles increase in frequency at approximately the same rate. Gene flow through pollen or seed movement from resistant weed populations can provide a source of resistance alleles in previously susceptible populations. Because rates of gene flow are generally higher than rates of mutation, the time required to reach a high level of resistance in such situations is greatly reduced. Contrary to common misconception, gene flow from a susceptible population to a population undergoing resistance evolution is unlikely to slow the evolutionary process significantly. Accurate measurements of many factors that influence resistance evolution are difficult, if not impossible, to obtain experimentally. Thus, the use of models to predict times to resistance in specific situations is markedly limited. However, with appropriate assumptions, they can be invaluable in assessing the relative effectiveness of various management practices to avoid, or delay, the occurrence of herbicide resistance in weed populations.
OBSERVING THE EMERGENCE OF CONSTRUCTIONAL KNOWLEDGE
Authors: Römer Ute , Berger Cynthia M.
Published: May 2019

Based on writing produced by second language learners at different proficiency levels (CEFR A1 to C1), we adopted a usage-based approach (Ellis, Römer, & O’Donnell, 2016; Tyler & Ortega, 2018) to investigate how German and Spanish learner knowledge of 19 English verb-argument constructions (VACs; e.g., “Vwithn,” illustrated byhe always agrees with her) develops. We extracted VACs from subsets of the Education First-Cambridge Open Language Database, altogether comprising more than 68,000 texts and 6 million words. For each VAC, L1 learner group, and proficiency level, we determined type and token frequencies, as well as the most dominant verb-VAC associations. To study effects of proficiency and L1 on VAC production, we carried out correlation analyses to compare verb-VAC associations of learners at different levels and different L1 backgrounds. We also correlated each learner dataset with comparable data from a large reference corpus of native English usage. Results indicate that with increasing proficiency, learners expand their VAC repertoire and productivity, and verb-VAC associations move closer to native usage.
Psychometric Properties of Spanish Version Student Utrecht Work Engagement Scale (UWES–S–9) in High-school Students
Authors: Serrano Cristina , Andreu Yolanda , Murgui Sergio , Martínez Paula
Published: May 2019

The Utrecht Work Engagement Scale (UWES) is a self-report instrument widely used, both in the original and its abbreviated version of nine items, to assess the work -UWES, UWES–9– and academic engagement -UWES-S, UWES–S–9–. The present study examines factor structure of the UWES–S–9 using confirmatory factor analysis (CFA), its convergent validity and invariance across sex and age groups in a sample of 626 Spanish high school students. The results support an unidimensional conceptualization of engagement (S-Bχ2/df= 5.29; CFI = .96; NNFI = .94; RMSEA = .083; IFI = .96; AIC = 82.21; BIC = 267.38), revealed an essentially invariant structure of the UWES–S–9 across the sex, ΔS-Bχ2(Δ6)= 10.67;p≤ .05, and age, ΔS-Bχ2(Δ7)= 9.67;p≤ .05, and confirmed the positive association between academic engagement and achievement (r= .30;p≤ .001), dispositional optimism (r= .21;p≤ .001), and subjective well-being (r= .16;p≤ .001), and the negative association with perceived stress (r=. –13;p≤ .001). In short, the Spanish version of UWES–S–9 is presented as a brief, reliable and valid tool to measure academic engagement in high school students (α = .91, AVE = .52, Ω = .911).
Do Self-Reports and Informant-Ratings Measure the Same Personality	Constructs?
Authors: Mõttus René , Allik Jüri , Realo Anu
Published: May 2019

Abstract. Personality researchers often supplement or substitute self-reports with ratings from knowledgeable informants, at least implicitly assuming that the same constructs are being measured regardless of the source of ratings. However, measurement invariance (MI) of personality constructs across these rating types has rarely been empirically tested. Here, this was done for the Five-Factor Model domains and their 30 facets ( N = 3,253). All facets and all domains but Agreeableness met the level of invariance (metric MI) required for comparing the relative standings of individuals across self-reports and informant-ratings, which is what researchers mostly do. However, ten facets and the Agreeableness domain failed to achieve the level of invariance (scalar MI) recommended when comparing mean scores. In conclusion, self-reports and informant-ratings appear to measure similar constructs for most research purposes.
The Latin Square Task as a Measure of Relational	Reasoning
Authors: Hearne Luke J. , Birney Damian P. , Cocchi Luca , Mattingley Jason B.
Published: May 2019

Abstract. The Latin Square Task (LST) is a relational reasoning paradigm developed by Birney, Halford, and Andrews (2006) . Previous work has shown that the LST elicits typical reasoning complexity effects, such that increases in complexity are associated with decrements in task accuracy and increases in response times. Here we modified the LST for use in functional brain imaging experiments, in which presentation durations must be strictly controlled, and assessed its validity and reliability. Modifications included presenting the components within each trial serially, such that the reasoning and response periods were separated. In addition, the inspection time for each LST problem was constrained to five seconds. We replicated previous findings of higher error rates and slower response times with increasing relational complexity and observed relatively large effect sizes (η2p > 0.70, r > .50). Moreover, measures of internal consistency and test-retest reliability confirmed the stability of the LST within and across separate testing sessions. Interestingly, we found that limiting the inspection time for individual problems in the LST had little effect on accuracy relative to the unconstrained times used in previous work, a finding that is important for future brain imaging experiments aimed at investigating the neural correlates of relational reasoning.
DInSAR Analysis and Analytical Modeling of Mount Etna Displacements: The December 2018 Volcano‐Tectonic Crisis
Authors: De Novellis V. , Atzori S. , De Luca C. , Manzo M. , Valerio E. , Bonano M. , Cardaci C. , Castaldo R. , Di Bucci D. , Manunta M. , Onorato G. , Pepe S. , Solaro G. , Tizzani P. , Zinno I. , Neri M. , Lanari R. , Casu F.
Published: May 2019

We investigate the 24–27 December 2018 eruption of Mount Etna occurred from fissures located on the volcano eastern flank and accompanied by a seismic swarm, which was triggered by the magma intrusion and continued for weeks after the end of the eruption. Moreover, this swarm involved some of the shallow volcano‐tectonic structures located on the Mount Etna flanks and culminated on 26 December with the strongest event (ML 4.8), occurred along the Fiandaca Fault. In this work, we analyze seismological data and Sentinel‐1 Differential Interferometric Synthetic Aperture Radar (DInSAR) measurements, the latter inverted through analytical modeling. Our results suggest that a dike source intruded, promoting the opening of the eruptive fissures fed by a shallower dike. Moreover, our findings indicate that the activation of faults in different sectors of the volcano may be considered as a response to accommodate the deformations induced by the magma volumes injection.
Mechanism for oral tumor cell lysyl oxidase like-2 in cancer development: synergy with PDGF-AB
Authors: Mahjour Faranak , Dambal Vrinda , Shrestha Neha , Singh Varun , Noonan Vikki , Kantarci Alpdogan , Trackman Philip C.
Published: May 2019

Extracellular lysyl oxidases (LOX and LOXL1–LOXL4) are critical for collagen biosynthesis. LOXL2 is a marker of poor survival in oral squamous cell cancer. We investigated mechanisms by which tumor cell secreted LOXL2 targets proximal mesenchymal cells to enhance tumor growth and metastasis. This study identified the first molecular mechanism for LOXL2 in the promotion of cancer via its enzymatic modification of a non-collagenous substrate in the context of paracrine signaling between tumor cells and resident fibroblasts. The role and mechanism of active LOXL2 in promoting oral cancer was evaluated and employed a novel LOXL2 small molecule inhibitor, PSX-S1C, administered to immunodeficient, and syngeneic immunocompetent orthotopic oral cancer mouse models. Tumor growth, histopathology, and metastases were monitored. In vitro mechanistic studies with conditioned tumor cell medium treatment of normal human oral fibroblasts were carried out in the presence and absence of the LOXL2 inhibitor to identify signaling mechanisms promoted by LOXL2 activity. Inhibition of LOXL2 attenuated cancer growth and lymph node metastases in the orthotopic tongue mouse models. Immunohistochemistry data indicated that LOXL2 expression in and around tumors was decreased in mice treated with the inhibitor. Inhibition of LOXL2 activity by administration of PXS-S1C to mice reduced tumor cell proliferation, accompanied by changes in morphology and in the expression of epithelial to mesenchymal transition markers. In vitro studies identified PDGFRβ as a direct substrate for LOXL2, and indicated that LOXL2 and PDGF-AB together secreted by tumor cells optimally activated PDGFRβ in fibroblasts to promote proliferation and the tendency toward fibrosis via ERK activation, but not AKT. Optimal fibroblast proliferation in vitro required LOXL2 activity, while tumor cell proliferation did not. Thus, tumor cell-derived LOXL2 in the microenvironment directly targets neighboring resident cells to promote a permissive local niche, in addition to its known role in collagen maturation.
Meta-analysis of urbanization impact on rainfall modification
Authors: Liu Jie , Niyogi Dev
Published: May 2019

Even though it is known that urbanization affects rainfall, studies vary regarding the magnitude and location of rainfall change. To develop a comprehensive understanding of rainfall modification due to urbanization, a systematic meta-analysis is undertaken. The initial search identified over 2000 papers of which 489 were carefully analyzed. From these papers, 85 studies from 48 papers could be used in a quantitative meta-analysis assessment. Results were analyzed for case studies versus climatological assessments, observational versus modeling studies and for day versus night. Results highlight that urbanization modifies rainfall, such that mean precipitation is enhanced by 18% downwind of the city, 16% over the city, 2% on the left and 4% on the right with respect to the storm direction. The rainfall enhancement occurred approximately 20–50 km from the city center. Study results help develop a more complete picture of the role of urban processes in rainfall modification and highlight that rainfall increases not only downwind of the city but also over the city. These findings have implications for urban flooding as well as hydroclimatological studies. This meta-analysis highlights the need for standardizing how the results are presented in future studies to aid the generalization of findings.
Temporal dependence of shifts in mu opioid receptor mobility at the cell surface after agonist binding observed by single-particle tracking
Authors: Metz Marissa J. , Pennock Reagan L. , Krapf Diego , Hentges Shane T.
Published: May 2019

Agonist binding to the mu opioid receptor (MOR) results in conformational changes that allow recruitment of G-proteins, activation of downstream effectors and eventual desensitization and internalization, all of which could affect receptor mobility. The present study employed single particle tracking (SPT) of quantum dot labeled FLAG-tagged MORs to examine shifts in MOR mobility after agonist binding. FLAG-MORs on the plasma membrane were in both mobile and immobile states under basal conditions. Activation of FLAG-MORs with DAMGO caused an acute increase in the fraction of mobile MORs, and free portions of mobile tracks were partially dependent on interactions with G-proteins. In contrast, 10-minute exposure to DAMGO or morphine increased the fraction of immobile FLAG-MORs. While the decrease in mobility with prolonged DAMGO exposure corresponded to an increase in colocalization with clathrin, the increase in colocalization was present in both mobile and immobile FLAG-MORs. Thus, no single mobility state of the receptor accounted for colocalization with clathrin. These findings demonstrate that SPT can be used to track agonist-dependent changes in MOR mobility over time, but that the mobility states observed likely arise from a diverse set of interactions and will be most informative when examined in concert with particular downstream effectors.
Implications of genetic variation of common Drug Metabolizing Enzymes and ABC Transporters among the Pakistani Population
Authors: Afsar Nasir Ali , Bruckmueller Henrike , Werk Anneke Nina , Nisar Muhammad Kashif , Ahmad H. R. , Cascorbi Ingolf
Published: May 2019

Genetic polymorphism of drug metabolizing enzymes and transporters may influence drug response. The frequency varies substantially between ethnicities thus having implications on appropriate selection and dosage of various drugs in different populations. The distribution of genetic polymorphisms in healthy Pakistanis has so far not been described. In this study, 155 healthy adults (98 females) were included from all districts of Karachi. DNA was extracted from saliva and genotyped for relevant SNVs in CYP1A1, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP3A4 and CYP3A5 as well as ALDH3A1, GSTA1, ABCB1 and ABCC2. About 64% of the participants were born to parents who were unrelated to each other. There was generally a higher prevalence (p < 0.05) of variant alleles of CYP450 1A2, 2B6, 2C19, 3A5, ALDH3A1, GSTM1 as well as ABCB1 and ABCC2 in this study cohort than in other ethnicities reported in the HapMap database. In contrast, the prevalence of variant alleles was lower in GSTA1. Therefore, in the Pakistani population sample from Karachi a significantly different prevalence of variant drug metabolizing enzymes and ABC transporters was observed as compared to other ethnicities, which could have putative clinical consequences on drug efficacy and safety.
The role of the triglyceride (triacylglycerol) glucose index in the development of cardiovascular events: a retrospective cohort analysis
Authors: Li Sangsang , Guo Bingxin , Chen Huanan , Shi Zhan , Li Yapeng , Tian Qingfeng , Shi Songhe
Published: May 2019

This study aimed to evaluate the role of the triglyceride (triacylglycerol) glucose (TyG) index in predicting and mediating the development of cardiovascular disease (CVD). This cohort study included 6078 participants aged over 60 years who participated in a routine health check-up programme from 2011 to 2017. The competing risk model, cox regression model and multimediator analyses were performed. TyG was calculated as ln [fasting triglyceride (mg/dl) × fasting plasma glucose (mg/dl)/2]. During a median 6 years of follow-up, 705 (21.01/1000 person-years) CVD events occurred. In fully adjusted analyses, quartiles 3 and 4 versus quartile 1 of TyG index (adjusted subhazard ratios [SHRs] 1.33 [95% CI: 1.05–1.68] and 1.72 [1.37–2.16]) were associated with an increased risk of CVD events. The continuous time-dependent TyG remained significant in predicting CVD events (adjusted hazard ratios [HR] 1.43 [1.24–1.63]). The adverse estimated effects of body mass index (BMI) or resting heart rate (RHR) on CVD mediated through the joint effect of the baseline and follow-up TyG index. In addition, an effect mediated only through the follow-up TyG existed (P < 0.05). Thus, it is necessary to routinely measure the TyG. The TyG index might be useful for predicting CVD events in clinical practice.
A Device for measuring the in-situ response of Human Bronchial Epithelial Cells to airborne environmental agents
Authors: Chandrala Lakshmana D. , Afshar-Mohajer Nima , Nishida Kristine , Ronzhes Yury , Sidhaye Venkataramana K. , Koehler Kirsten , Katz Joseph
Published: May 2019

Measuring the time evolution of response of Normal Human Bronchial Epithelial (NHBE) cells to aerosols is essential for understanding the pathogenesis of airway disease. This study introduces a novel Real-Time Examination of Cell Exposure (RTECE) system, which enables direct in situ assessment of functional responses of the cell culture during and following exposure to environmental agents. Included are cell morphology, migration, and specialised responses, such as ciliary beat frequency (CBF). Utilising annular nozzles for aerosol injection and installing windows above and below the culture, the cells can be illuminated and examined during exposure. The performance of RTECE is compared to that of the commercial Vitrocell by exposing NHBE cells to cigarette smoke. Both systems show the same mass deposition and similar trends in smoke-induced changes to monolayer permeability, CBF and transepithelial resistance. In situ measurements performed during and after two exposures to smoke show that the CBF decreases gradually during both exposures, recovering after the first, but decreasing sharply after the second. Using Particle image velocimetry, the cell motions are monitored for twelve hours. Exposure to smoke increases the spatially-averaged cell velocity by an order of magnitude. The relative motion between cells peaks shortly after each exposure, but remains elevated and even increases further several hours later.
Developing a Quantitative Ultrasound Image Feature Analysis Scheme to Assess Tumor Treatment Efficacy Using a Mouse Model
Authors: Mirniaharikandehei Seyedehnafiseh , VanOsdol Joshua , Heidari Morteza , Danala Gopichandh , Sethuraman Sri Nandhini , Ranjan Ashish , Zheng Bin
Published: May 2019

The aim of this study is to investigate the feasibility of identifying and applying quantitative imaging features computed from ultrasound images of athymic nude mice to predict tumor response to treatment at an early stage. A computer-aided detection (CAD) scheme with a graphic user interface was developed to conduct tumor segmentation and image feature analysis. A dataset involving ultrasound images of 23 athymic nude mice bearing C26 mouse adenocarcinomas was assembled. These mice were divided into 7 treatment groups utilizing a combination of thermal and nanoparticle-controlled drug delivery. Longitudinal ultrasound images of mice were taken prior and post-treatment in day 3 and day 6. After tumor segmentation, CAD scheme computed image features and created four feature pools including features computed from (1) prior treatment images only and (2) difference between prior and post-treatment images of day 3 and day 6, respectively. To predict tumor treatment efficacy, data analysis was performed to identify top image features and an optimal feature fusion method, which have a higher correlation to tumor size increase ratio (TSIR) determined at Day 10. Using image features computed from day 3, the highest Pearson Correlation coefficients between the top two features selected from two feature pools versus TSIR were 0.373 and 0.552, respectively. Using an equally weighted fusion method of two features computed from prior and post-treatment images, the correlation coefficient increased to 0.679. Meanwhile, using image features computed from day 6, the highest correlation coefficient was 0.680. Study demonstrated the feasibility of extracting quantitative image features from the ultrasound images taken at an early treatment stage to predict tumor response to therapies.
Bayesian Data Analysis for Revealing Causes of the Middle Pleistocene Transition
Authors: Mukhin Dmitry , Gavrilov Andrey , Loskutov Evgeny , Kurths Juergen , Feigin Alexander
Published: May 2019

Currently, causes of the middle Pleistocene transition (MPT) – the onset of large-amplitude glacial variability with 100 kyr time scale instead of regular 41 kyr cycles before – are a challenging puzzle in Paleoclimatology. Here we show how a Bayesian data analysis based on machine learning approaches can help to reveal the main mechanisms underlying the Pleistocene variability, which most likely explain proxy records and can be used for testing existing theories. We construct a Bayesian data-driven model from benthic δ18O records (LR04 stack) accounting for the main factors which may potentially impact climate of the Pleistocene: internal climate dynamics, gradual trends, variations of insolation, and millennial variability. In contrast to some theories, we uncover that under long-term trends in climate, the strong glacial cycles have appeared due to internal nonlinear oscillations induced by millennial noise. We find that while the orbital Milankovitch forcing does not matter for the MPT onset, the obliquity oscillation phase-locks the climate cycles through the meridional gradient of insolation.
Hydrothermal generation, structural versatility and properties of metal(ii)-organic architectures driven by a pyridine-tricarboxylic acid
Authors: Zhao Na , Li Yu , Gu Jin-Zhong , Kirillova Marina V. , Kirillov Alexander M.
Published: May 2019

A new series of metal(ii) coordination compounds driven by a pyridine-tricarboxylate block was generated, their structural features, magnetic, luminescent or photocatalytic properties were explored.
Computational studies of ene reactions between aminoborane (F3C)2BN(CH3)2and substituted propenes: additive effects on barriers and reaction energies
Authors: Gille Austin L. , Hammer Staci E. , Lafferty Jenna M. , Lawson Keaton R. , Gustafson James R. , Dutmer Brendan C. , Gilbert Thomas M.
Published: May 2019

Investigations of ene reactions between (F3C)2BNMe2and substituted propenes reveal additive substitutional effects on barriers and reaction energies.
How important is the coordinating atom in controlling magnetic anisotropy in uranium(iii) single-ion magnets? A theoretical perspective
Authors: Dey Sourav , Velmurugan Gunasekaran , Rajaraman Gopalan
Published: May 2019

Strong dependency of magnetic anisotropy on U(iii) centre by the nature of coordinating atom of the ligand (carbon vs. nitrogen) is studied using ab initio calculations employing well-characterised systems [U(BcMe)3] and [U(BpMe)3].
Bilberry anthocyanin improves the serum cholesterol in aging perimenopausal rats via the estrogen receptor signaling pathway
Authors: Li Na , Li Jing , Hao Junyu , Zhang Min , Yin Jinjin , Geng Jieting , Wu Tao , Lyv Xiaoling
Published: May 2019

With aging, there is an increasing risk for women to develop perimenopause syndrome, which is harmful to women's physical and mental health.
MHD simulations of the in situ generation of kink and sausage waves in the solar corona by collision of dense plasma clumps
Authors: Pagano P. , Van Damme H. J. , Antolin P. , De Moortel I.
Published: May 2019

Context. Magnetohydrodynamic (MHD) waves are ubiquitous in the solar corona where the highly structured magnetic fields provide efficient wave guides for their propagation. While MHD waves have been observed originating from lower layers of the solar atmosphere, recent studies have shown that some can be generated in situ by the collision of dense counter-propagating flows.

Aims. In this theoretical study, we analyse the mechanism that triggers the propagation of kink and sausage modes in the solar corona following the collision of counter-propagating flows, and how the properties of the flows affect the properties of the generated waves.

Methods. To study in detail this mechanism we ran a series of ideal 2D and 3D MHD simulations where we varied the properties of the counter-propagating flows; by means of a simple technique to estimate the amplitudes of the kink and sausage modes, we investigated their role in the generation and propagation of the MHD waves.

Results. We find that the amplitude of the waves is largely dependent on the kinetic energy of the flows, and that the onset of kink or sausage modes depends on the asymmetries between the colliding blobs. Moreover, the initial wavelength of the MHD waves is associated with the magnetic configuration resulting from the collision of the flows. We also find that genuine 3D systems respond with smaller wave amplitudes.

Conclusions. In this study, we present a parameter space description of the mechanism that leads to the generation of MHD waves from the collision of flows in the corona. Future observations of these waves can be used to understand the properties of the plasma and magnetic field of the solar corona.