bluuebunny/crossref_metadata_2025 huggingface dataset:
Creation of thesauri of regulatory and legal information in the conditions of digitalization
Authors: BRAYCHEVSKYY S.
Published: April 2022

The issues of automation of creation of subject thesauri in the field of regulatory and legal information are considered in the work. It is proposed to use documents of the regulatory framework as a source of creating a lexicographic resource. The possibilities of such an approach are demonstrated on the example of data related to the qualification of crimes.
Status and prospects of development of the management system of a parliamentary institution as a basis for improving the organizational and legal mechanism of parliamentary control
Authors: NIZHNIK A.
Published: April 2022

The article, based on a comparative analysis of the constitutional practices of European parliaments, outlines current trends in national parliamentary practice to optimize the parliamentary institution management system in the current government coalition model. The organizational and legal management mechanism peculiarities of a parliamentary institution as an integrated component of ensuring the implementation of internal and external parliamentary control are described.
Exploring the resilience of adults with autism spectrum disorder: A Scoping Review protocol
Authors:   National University of Ireland Galway., Whelan Sally , Ledis Gabriella , Menecola Alayna , Schulte Madie , Semiao Giavanna , Mannion Arlene , Leader Geraldine
Published: April 2022

Review question / Objective: This review aims to explore resilience in the context of autistic adults. To fulfil this aim, the review has the following objectives: • To explore how adults with autism experience and perceive their resilience. • To identify how empirical research has defined and measured resilience in populations of adults with autism. • To identify how resilience in autistic adults can be understood in terms of the resilience process. • To identify factors that can support the resilience of adults with autism. Condition being studied: Autism is a lifelong neurodevelopmental condition that has core features of intense interests, affective and social interaction difficulties, and a preference for repetitive behaviours (American Psychiatric Association, 2013). Resilience has been defined as an outcome, and/or a process through which people use resources to adapt positively to adversity, stress, or trauma (Windle, 2011).
The effect of acupressure for insomnia : A systematic review and meta-analysis
Authors:   National Cheng Kung University, Lee Huan-Fang , Liu Tzu-Yu , Lai Pei-Chun
Published: April 2022

Review question / Objective: This study aims to discuss the effectiveness of acupressure, without combining any other objects or methods, in treating insomnia. Condition being studied: Previous studies mostly chose acupuncture as intervention ; even if relevant studies were found, it was rare for them to solely focus on acupressure as many of which combined other methods to compare with the control groups. In the recent systematic reviews about insomnia, selected populations, hemodialysis and hypertensive patients, in particular, were put more emphasis on. Nevertheless, most of the studies included in these reviews have the same problem mentioned above. On top of that, the placebo effect in control group was not often considered, making it hard for us to truly distinguish the effectiveness of acupressure.
Applying the models of magneto-rheological substances in the study of exoskeleton variable-length link with adjustable stiffness
Authors:   Branch of the National Research University ", Blinov Alexander О. ,   MPEI",   in Smolensk, Konchina Larisa V. ,   Branch of the National Research University "MPEI" in Smolensk, Novikova Marina А. ,   The Branch of National Research University MPEI in Smolensk, Borisov Andrey V. ,   The Branch of National Research University MPEI in Smolensk
Published: April 2022

The article considers the existing mathematical models of magneto-rheological substances and describes some of their properties. As a result of the open sources analysis, it was found that there are no exoskeleton models with variable-length links with adjustable stiffness, based on the application of magneto-rheological fluids. Therefore, the application of these fluids in other technical systems is considered. A mathematical model of an exoskeleton variable-length link with adjustable stiffness is proposed. This link can be used for supporting and strengthening the lower limbs of the human musculoskeletal system. The difference between the proposed mathematical model of the link and the existing ones lies in the fact that the section that changes its length is considered weighty. Therefore, the mathematical model of the link with a variable inertial characteristic, the moment of inertia relative to the axis perpendicular to the longitudinal axis of the link symmetry and passing through its beginning – the point where the link is fixed to the stationary mount with a cylindrical hinge, is considered. A method of motion control based on the assignment of differentiable functions is applied. The trajectory of the link movement is found, linear and angular velocities and accelerations are calculated. To showcase the link motion, the computer-animated visualization of the link motion control problem solution is presented. The control actions required for the implementation of the given motion have been calculated in the numerical experiment. The drag coefficient range of the magneto-rheological substance has been identified during the implementation of the proposed link motion. The software implementation of the proposed mathematical model of the exoskeleton variable-length link with adjustable stiffness has been done in the Wolfram Mathematica 11.3 universal computer math environment. The software package including the unit for deriving the differential equations of motion in analytical form, the kinematic trajectory synthesis unit, the computational experiment unit, and the unit for animated visualization of the model motion and its export in the wide-spread 'gif' video format has been developed.
Development of the architecture of an intelligent information system oracle programs blockchain management systems
Authors:   Synergy University, Gumerov Emil A. , Alekseeva Tamara V. ,   Synergy University
Published: April 2022

Oracle programs are a key link in the interaction of blockchain systems with the outside world. They must ensure the authenticity and security of data transmitted over a computer network to blockchain smart contracts. It is possible to increase security by creating a blockchain network for oracle programs, and a consensus of independent assessments of the authenticity of data in oracle programs will ensure the security of data transmitted to the main blockchain. Blockchain control systems in real time take several milliseconds to verify the authenticity of data, to data mining and to develop a control effect on the actuators. The consensus mechanism, which requires much more time, is not acceptable in these management systems. The purpose of this work is to develop the architecture of an intelligent information system of oracle programs for a real-time blockchain management system. To achieve the goal, the following tasks were solved: analysis of the state of the problem of ensuring the reliability and completeness of data, research of the capabilities of intelligent smart contracts, research of the intellectual capabilities of peripheral computing, development of the architecture of an intelligent information system of oracle programs. The scientific novelty of the work consists in the fact that a way has been found for high-speed transmission of the reliability of data transmitted by the oracle program system to the smart contracts of the blockchain management system in real time. The practical significance of the work is to solve the problem of providing reliable data to the blockchain management system in real time.
Genotypic and Phenotypic Characterisation of Isolated Marine Bacteria and its Potential to Produce Alkaline Protease
Authors: Maya Dehimi  , Faridah Yusof  , Raha Ahmad Raus  , Noor Faizul Hadry  , Radhia Nedjai
Published: April 2022

In several industries such as food and detergent, enzymes are commonly used out of which microorganisms' proteolytic enzymes are dominant. Microorganisms from marine sources have advantageous commercial characteristics when it comes to protease production. Protease producing bacterial strains were isolated from four different stations in the South China Sea, located at Kuantan, Pahang-Malaysia. The temperature was ranging from 29 to 36.2°C; salinity varied from 36,18 to 37,9 ppt, turbidity from 10.21 to 16.4 NTU. Dissolved Oxygen had an average of 4.44 mg/mL, and pH was around 8. All the bacterial strains were screened for protease activity using Skim Milk agar plates. Out of 18 isolates, ten strains formed a clear zone on skim milk agar plates. Molecular identification by 16S rRNA results revealed that Bacillus spp was the most dominant bacteria, four isolates belong to Bacillus cereus, another 04 identified as Bacillus licheniformis in addition of one isolate was Bacillus safensis. They were followed by one isolate Staphylococcus warneri. Furthermore, a phenotypic characterization is conducted using The Biolog GENIII MicroPlate with 94 phenotypic tests. These tests consist of 71 carbon source utilization assays and 23 chemical sensitivity assays. The proteolytic activity was confirmed through a quantitative protease assay. Where the strain B. cereus-MD152 was the highest yield, followed by B. licheniformis-ABN13. On the contrary, the lowest yield was secreted by B. cereus-IIUM6 with no more than 16.5 U/ml.
Effect of Gamma Irradiation on Physicochemical Properties and Microbiological Quality of Yellow Noodle with Addition of Rice Bran
Authors: Farah Nadiah Abd Rahim  , Wan-Zunairah Wan-Ibadullah  , Nor Izzati Ibrahim  , Ahmad Zainuri Mohamad Dzomir  , Radhiah Shukri  , Nur Hanani Zainal Abedin  , Nor Afizah Mustapha  , Nor-Khaizura Mahmud Ab Rashid  , Ismail-Fitry Mohammad Rashedi
Published: April 2022

Irradiation is principally used as preservation to improve food shelf-life. The effect of gamma irradiation on physicochemical properties and microbiological quality of yellow noodles with addition of rice bran were observed. Wheat flour was replaced with rice bran at different levels (5%, 10%, 15%, 20%). The rice bran yellow (RBY) noodles were exposed to different irradiation doses (4 kGy, 6 kGy 8 kGy) using Cobalt-60. Gamma irradiation significantly decreased the pH, moisture content, hardness, lightness and redness; whereas significantly increased the breaking length of RBY noodles. Total plate count of RBY noodles stored at 8°C was observed on day 0, 3, 5 and 7. No bacterial growth was observed at dose 6 kGy and 8 kGy on day 5 and 7. Micrograph of RBY noodles under SEM at 500x magnification showed that different gamma irradiation dose and replacement of rice bran resulted in small changes on starch granules. Additionally, increment of rice bran showed significant increase in moisture content, breaking length, redness, cooking yield and cooking loss; but significantly decreased the water activity at high dose, hardness, lightness and yellowness. In conclusion, irradiation positively impacted the microbiological quality and incorporation of rice bran gave positive effect on the cooking yield.
The Effect of Maltodextrin and Acacia Gum on Encapsulation of Fig Powder Physicochemical Properties
Authors: Noorsabrina M. Salbi  , Norhayati Muhammad  , Norazlin Abdullah
Published: April 2022

In this study, the effect of coating material composition on the encapsulation of physical and chemical properties of fig powder was investigated. As coating material maltodextrin and acacia gum at different ratios were chosen (100% and 75%:25%). The core to coating ratio was 1:1. The microcapsules were prepared with high-speed homogenizer at 10000 rpm for 10 min. The vacuum dried microcapsules were analyzed in terms of moisture, total soluble solid, bulk and tapped density, Carr’s index, Hausher ratio, total flavonoid content, and antioxidant activity. The antioxidant activity was mostly higher when coating ratio was 100% acacia gum in the core and coating ratio of 1:1 as compared to others. There was positive correlation between total flavonoid content and antioxidant activity. Combination of coating agent in ratio 75%: 25% vice versa significantly improve the physical properties of fig powder. The ratio of maltodextrin and gum arabic had significant effect on all physical and chemical properties analyzed.
Carrier-to-Noise Ratio for Distributed Raman Amplifiers with Different Pumping Configurations
Authors: Arwa Hassan Beshr  , Moustafa H. Aly  , Mohamed B. Saleh  , Mahmoud Beshr
Published: April 2022

Distributed Raman amplifiers (DRAs) achieve higher bit rate, low noise figure, a decreased nonlinear penalty, long-haul transmission, small channel spacing and operating near zero dispersion wavelength. In this paper, a model is derived for the DRA carrier-to-noise ratio (CNR) caused by amplified spontaneous emission (ASE) using different pumping configurations: co-pumping, counter and bidirectional-pumping. The bit error rate (BER) is evaluated in the S-band from optical signal to noise ratio (OSNR). The simulation results show that, at 100 km fiber length, the CNR reaches its minimum value of 40 and 41 and 42 dB, in counter and bidirectional pumping, and 42 dB in co-pumping scheme. Moreover, the co-pumping provides the lowest BER in contrast to the counter pumping which achieves the highest BER among the three pumping schemes.
Chaotic and Clumpy Galaxy Formation in an Extremely Massive Reionization-era Halo
Authors: Spilker Justin S. , Hayward Christopher C. , Marrone Daniel P. , Aravena Manuel , Béthermin Matthieu , Burgoyne James , Chapman Scott C. , Greve Thomas R. , Gururajan Gayathri , Hezaveh Yashar D. , Hill Ryley , Litke Katrina C. , Lovell Christopher C. , Malkan Matthew A. , Murphy Eric J. , Narayanan Desika , Phadke Kedar A. , Reuter Cassie , Stark Antony A. , Sulzenauer Nikolaus , Vieira Joaquin D. , Vizgan David , Weiß Axel
Published: April 2022

The SPT 0311–58 system at z = 6.900 is an extremely massive structure within the reionization epoch and offers a chance to understand the formation of galaxies at an extreme peak in the primordial density field. We present 70 mas Atacama Large Millimeter/submillimeter Array observations of the dust continuum and [C ii] 158 μm emission in the central pair of galaxies and reach physical resolutions of ∼100–350 pc, among the most detailed views of any reionization-era system to date. The observations resolve the source into at least a dozen kiloparsec-size clumps. The global kinematics and high turbulent velocity dispersion within the galaxies present a striking contrast to recent claims of dynamically cold thin-disk kinematics in some dusty galaxies just 800 Myr later at z ∼ 4. We speculate that both gravitational interactions and fragmentation from massive parent disks have likely played a role in the overall dynamics and formation of clumps in the system. Each clump individually is comparable in mass to other 6 < z < 8 galaxies identified in rest-UV/optical deep field surveys, but with star formation rates elevated by a factor of ~3-5. Internally, the clumps themselves bear close resemblance to greatly scaled-up versions of virialized cloud-scale structures identified in low-redshift galaxies. Our observations are qualitatively similar to the chaotic and clumpy assembly within massive halos seen in simulations of high-redshift galaxies.
Cumulative effects of hypertriglyceridemia in HIV-infected patients switching from NNRTIs to PI-based antiretroviral therapy
Authors: Zhang Yu , Xiao Jiang , Zhang Wen , Han Ning , Yang Di , Liu Wei , Zeng Hui , Han Junyan , Zhao Hongxin
Published: April 2022

Introduction: The objective of this study was to investigate changes in serum lipids among HIV-infected patients switching from non-nucleoside-reverse transcriptase inhibitors (NNRTI) to protease inhibitor (PI)-based highly active antiretroviral therapy (HAART), and to determine if changes of lipid profiles impacted the monocyte subsets recovery.

Methodology: Fifty-seven subjects who switched from NNRTIs to PI-based HAART (NNRTIs to PI group) and fifty-five subjects who initially started with PI-based HAART (initial PI group) were recruited. According to their baseline triglyceride (TG) levels, the NNRTIs to PI and initial PI groups were further divided into non-hypertriglyceridemia and hypertriglyceridemia subgroups, respectively. The effects of PI-based HAART on lipid profiles and monocyte subsets were analyzed.

Results: At 48 weeks, the TG changes in the NNRTIs to PI group was higher than that of the initial PI group. The increases of serum TG levels in the initial PI non-hypertriglyceridemia group was greater than that of the NNRTIs to PI non-hypertriglyceridemia group. For the hypertriglyceridemia group at baseline, significant increment in TG levels were observed in the NNRTIs to PI hypertriglyceridemia group. The percentages of circulating CD14highCD16+ and CD14lowCD16+ subsets were elevated in the two groups. At 48 weeks, the proportion of CD14highCD16+ monocytes declined gradually, and the proportion of CD14lowCD16+ monocytes decreased independently of the TG level.

Conclusions: For non-hypertriglyceridemia individuals at baseline, PI-based regimens increased the TG level in the initial PI group. For the NNRTIs to PI hypertriglyceridemia group, PI-based regimens reinforced HAART-related hypertriglyceridemia.
Pulmonary aspergilloma in immunocompromised patients in a Respiratory Care Unit
Authors: Hernández-Solís Alejandro , Álvarez-Maldonado Pablo , Araiza-Santibáñez Javier , Cruz-Muñoz Kevin , Cícero-Sabido Raúl , Quintana Martínez Andrea
Published: April 2022

Introduction: Pulmonary aspergilloma is commonly associated with comorbidities that cause immunodeficiency such as diabetes mellitus, tuberculosis, human immunodeficiency virus/acquired immunodeficiency syndrome and/or a pre-existing parenchymal lung disease such as chronic obstructive pulmonary disease. Predisposing factors can further increase the risk of acquiring this mycosis. Our objective was to determine the frequency, clinical and microbiological characteristics of pulmonary aspergilloma in immunocompromised patients.

Methodology: Retrospective case series of patients diagnosed with pulmonary aspergilloma in a respiratory care unit in Mexico City from 2000 to 2019 was studied. Bronchoalveolar lavage cultures on Sabouraud-dextrose agar and serum galactomannan determination were performed on each patient.

Results: We identified twenty-four patients with pulmonary aspergilloma (sixteen male and eight female), thirteen had a history of tuberculosis (54%), seven of diabetes mellitus (29%), three of human immunodeficiency virus/acquired immunodeficiency syndrome (13%) and one of chronic obstructive pulmonary disease (4%). The most commonly reported symptoms were hemoptysis in eighteen patients (75%), dyspnea in sixteen patients (67%) and chest pain in thirteen patients (54%). Aspergillus fumigatus was identified in all cultures and galactomannan was positive in 21 serum samples (87%).

Conclusions: Coexistence of diseases that could suppress the immune system predispose to pulmonary aspergilloma; clinical presentation is often confused with other systemic diseases. A high degree of clinical suspicion is important for early detection.
A case of pulmonary histoplasmosis treated with voriconazole
Authors: Xie Congyi , Yang Yimin , Wu Xiaodan , Chen Zhangzhang , Zhu Na , Song Yuanlin , Tong Lin
Published: April 2022

Histoplasmosis is an infection caused by the dimorphic fungus Histoplasma capsulatum. The lungs are the most common site of infection, especially in patients with immune deficiency. We report a case of 62-year-old male patient presented with cough for 3 months and had been taking immunosuppressive drugs for 10 years after heart transplantation. Chest CT scan showed multiple pulmonary nodules. Lung tissue biopsy specimen culture suggested fungal infection, and Histoplasma capsulatum was confirmed by next-generation sequencing (NGS) detection. The patient was diagnosed with pulmonary histoplasmosis. After administration of voriconazole for 46 days, the symptom of cough was markedly relieved and the lesions were partly absorbed. After 13 months of treatment, the lesions completely disappeared, and no significant side-effect of voriconazole was observed. To our knowledge, report of voriconazole as the treatment of histoplasmosis is rare, especially in non-endemic areas. Moreover, this case enriches our experience in the adjustment between immunosuppressive and antifungal agents in treating histoplasmosis.
Clinical characteristics and risk factors associated with severe disease and outcome of patients with COVID-19
Authors: Ozel Ayse Serra , Altunal Lutfiye Nilsun , Aydin Mehtap , Unal Busra , Cam Gulsum , Caglar Ozer Merve , Korten Volkan
Published: April 2022

Introduction: Since the beginning of the pandemic, factors associated with mortality in patients with corona virus infection disease 2019 (COVID-19) have been investigated. Comorbidities and increased age have been frequently reported to be associated with mortality. We aimed to evaluate the factors associated with unfavorable outcome of patients with COVID-19 at an early period of the pandemic.

Methodology: This single center, retrospective, observational study was conducted among laboratory confirmed COVID-19 patients hospitalized between March 11 and May 5, 2020, at Umraniye Training and Research Hospital, Istanbul, Turkey. The effects of the severity of illness, comorbidities, symptoms, and laboratory findings on the clinical outcome were evaluated. Factors associated with unfavorable outcome (necessity of mechanical ventilation or death) were examined using Cox proportional hazards models.

Results: Out of a total of 728 patients, 53.8% were men and median age 54 years. The 30-day mortality rate was 4.9% among all hospitalized patients. A logistic regression model identified six predictors of unfavorable clinical outcome: age, severity of illness, the numbers of comorbidities, lymphopenia, high levels of C-reactive protein, and procalcitonin.

Conclusions: The mortality rate was lower among the patients with COVID-19, hospitalized during the early period of the pandemic. Older age, higher severity score on admission, the numbers of comorbidities, higher levels of C-reactive protein, procalcitonin, and lymphopenia were identified to be associated with unfavorable outcome of the hospitalized patients with COVID-19.
The Tuberculosis and COVID-19 coinfection: A report of two cases at a tertiary referral in Indonesia
Authors: Zaini Jamal , Fadhillah Muhamad Rizqy , Reisa Tina , Isbaniyah Fathiyah , Handayani Raden Rara Diah
Published: April 2022

COVID-19 cases are still rising globally in the middle of the tuberculosis epidemic. Several countries have reported TB-COVID-19 coinfection that could pose a double burden in the health care facilities in developing countries. We reported two pulmonary tuberculosis patients coinfected with COVID-19 with an overlapping clinical manifestation of tuberculosis and COVID-19 with a good prognosis at the end of COVID-19 treatment. This paper aims to discuss TB patients' susceptibility against SARS-COV-2 infection, the clinical profile of TB-COVID-19 coinfection, and the disease's prognosis. The clinician should be aware of both common disease symptoms that appear in a patient and should be confirmed and treat promptly.
Application of Chitosan and Hydroxyapatite in Periodontal Tissue Regeneration: A Review
Authors: Gani Asdar , Yulianti Risfah , Supiaty Supiaty , Rusdy Machirah
Published: April 2022

Chronic periodontitis is an infection caused by bacteria in the gum tissue that supports the teeth. The current periodontal therapy manages or removes periodontal infections and repairs the periodontium destroyed due to periodontal disease. Due to its biodegradability and biocompatibility, chitosan (CH) and hydroxyapatite (HAP) are employed for bone tissue healing. The purpose of this study was to compare the utilization of CH and HAP in the regeneration of periodontal tissue. The presented study is a systematic review prepared from a collection of recent relevant published articles. This research was conducted by reviewing articles from 2016 to August 2021. The analysis found that CH/HAP is a therapeutic strategy for chronic periodontitis patients that allow low-cost bone regeneration, mHA/CH scaffolds may inhibit the growth of periodontal pathogens, and CH or HAP has the potential to be developed bone tissue engineering.
A Trance Case Report with Ruqya (Exorcism) Approach in Aceh
Authors: Yulia Erlina , Effendy Elmeida , Amin Mustafa M.
Published: April 2022

Trance disorders or possessed spirit is a form of invisible control over human beings and they also have an influence on the mind, five sense organs, and body functions, which have similar symptoms to Dissociative Identity Disorder (DID). However, Ruqya, also known as Islamic exorcism, is a practice of exorcism in the form of incantations or spell recitation from the Qur’an and hadith. It is a great hope in Islamic society used as a form of treatment according to the Sunnah of the Prophet Mohammed. A 53-year-old businessman suffering from psychological problems brought by his 48-year-old wife to a raqi (ruqya practitioner) after being treated by a general medical practitioner for several months was presented. The ruqya procedure was conducted several times which shows an improvement in his mental state.
Formulation and in vitro evaluation of inosine acedoben dimepranol tablets
Authors: Kafedjiiski Krum
Published: April 2022

The present work was carried out to formulate and evaluate immediate release tablets of Inosine Acedoben Dimepranol (IAD). Tablets were prepared by wet granulation process to overcome the poor compression properties of IAD powder and produce high-dose tablets. Various type of binders and disintegrants like Povidone K-30, K-25, wheat starch, mannitol were used to prepare some series of tablets. Granules were evaluated for pre-compression parameters and tablets were evaluated for post- compression parameters. The composition batch № IAD L03 was the best for producing IAD 500 mg tablets. The optimal lubricant is glycerol dibehenate at a concentration of 3.08%. Optimized formulation was evaluated for in-vitro dissolution test. Stability studies were performed for the selected composition.
Treatment Guidelines for Rheumatoid Arthritis
Authors: Lee Jennifer Jooha
Published: April 2022

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease with synovitis and extra-articular systemic involvement. Chronic RA treatment is challenging and represents a major health burden worldwide. Recent insights regarding RA pathogenesis have led to novel therapeutic agents, especially biologics. Furthermore, accumulating experience and new clinical studies have helped to inform updated recommendations for treatment of RA. Recently, treatment guidelines from the American College of Rheumatology were released. Here, we review these guidelines and their application to daily practice.
Risk Factors for Dislocation After Reverse Total Shoulder Arthroplasty: A Systematic Review and Meta-Analysis
Authors: Loucas Marios , Borbas Paul , Vetter Maximilian , Loucas Rafael , Ernstbrunner Lukas , Wieser Karl
Published: April 2022

Instability after reverse total shoulder arthroplasty (RTSA) is a dreaded complication. Risk factors for postoperative instability are uncertain. The goal of this systematic review was to quantitatively and qualitatively analyze the risk factors for instability after RTSA. Of 1183 studies identified, 12 studies involving 3810 patients were included. The mean age was 68.8 years, and the mean follow-up was 46 months. The pooled rate of dislocation after RTSA was 4.0%. Several patient-specific and implant-specific risk factors have been identified, and especially the implant-specific risk factors appear avoidable with current knowledge, implant design, and technology. [
Orthopedics
. 2022;45(6):e303–e308.]
Teoría tullida. Un recorrido crítico desde los estudios de la discapacidad o diversidad funcional hasta la teoría CRIP
Authors: Moya Laura
Published: April 2022

Los estudios de la discapacidad cuentan con cuatro décadas de historia en las que este campo de conocimiento ha evolucionado y complejizado su análisis sumando nuevos enfoques teóricos y prácticos. En esta ocasión, con el fin de conocer la evolución de estos estudios hasta la teoría crip o teoría tullida, partimos del marco teórico anglosajón que nos permite trazar una genealogía de este campo de conocimiento para, posteriormente, poner esta en diálogo con la producida en nuestro contexto. Dado que los principales análisis del campo apenas han sido traducidos a nuestro idioma y que el mismo no cuenta con una amplia trayectoria en nuestro contexto, este artículo se propone como una breve guía de aproximación al campo de los estudios sobre la discapacidad y, en especial, al surgimiento de la teoría tullida.
Le multilinguisme de l’Organisation des Nations unies
Authors: Saint Robert Marie-Josée de
Published: April 2022

L’objet de cet article est d’analyser la politique linguistique de l’ONU, telle que définie en 1946, ainsi que les principaux obstacles rencontrés depuis lors pour la mettre en œuvre. Sont principalement décrits les efforts des États membres et du secrétaire général pour parvenir à la parité linguistique entre les deux langues de travail du Secrétariat que sont l’anglais et le français, et entre les six langues officielles des autres organes principaux des Nations unies, tels que l’Assemblée générale, à savoir l’anglais, l’arabe, le chinois, l’espagnol, le français et le russe. Leurs récents efforts en vue de l’intégration systématique du multilinguisme dans les activités de l’Organisation se sont traduits par la multiplication du nombre de langues employées au Secrétariat pour entendre et servir les peuples du monde, au point qu’un terme tel que « omnilinguisme » semble mieux rendre compte que « multilinguisme » de ce nouvel aspect de la politique linguistique de l’Organisation.
DESIGN AND DEVELOPMENT OF ADVANCED SIMILARITY MEASURE FOR RECONSTRUCTING GRN USING mRNA EXPRESSION PROFILES
Authors: Bhyratae Suhas A. , Mangla Neha
Published: April 2022

Gene Regulatory Networks (GRNs) reconstruction aims to infer relationships of potential regulation among the genes. With the rapid growth of the biotechnology, such as Ribonucleic acid (RNA)-sequencing and gene chip microarray, the generated high-throughput data provide gene–gene interaction relationships with more opportunities based on gene expression data. Several approaches are introduced to reconstruct the GRNs, but low accuracy is a major drawback. Hence, this paper introduces the hybrid distance measure and the Pearson’s correlation coefficient for reconstructing GRN. The hybrid distance, such as Tversky index, Tanimoto similarity, and Minkowski distance, is employed to connect the edges. The asymmetric partial correlation network is introduced for determining two influence functions for every pair, and edge direction is determined among them. However, the direction of edges is unknown usually and seems difficult to be identified based on gene expression data. Thus, it extends the data processing inequality applying in the directed network for removing the transitive interactions. The influence value of every node is calculated for identifying the significant regulator. The performance of the proposed Hybrid Distance_Entropy based GRN Reconstruction method is analyzed in terms of correlation, reconstruction error, precision, and recall, which provides superior results with values 0.9450, 0.00052, 0.9095, and 0.8913 based on dataset-1.
A Case of Affordances
Authors: Sharma Swapnil , Mir Umar Bashir , Kar Arpan Kumar , Gupta M. P.
Published: April 2022

This study attempts to explore the contextual factors that play a significant role in promoting collaborative governance using mobile phones in developing countries. The study utilises review of academic literature and experts’ opinion to identify critical conversion factors and their interrelationship. Affordance Theory is used as a theoretical lens to identify eight significant factors covering development of infrastructure, citizen up-skilling, cost of access, ease of use, reliable infrastructure, ensured privacy & security, process accountability and a standardised m-governance policy. A combination of Total Interpretative Structure Modelling (TISM) and Cross-impact matrix multiplication applied to classification (MICMAC) analysis is employed to prioritise these conversion factors and classify them based on their dependence and driving power. A priority-based hierarchical model is proposed for establishing a sustainable m-governance ecosystem.
Alleviation of Health Complaints Following Regular Consumption of Filtered Tap Water (AcalaQuell®) Is Independent from Placebo Effects
Authors: Schneider Rainer
Published: April 2022

Recently, it was shown that regular consumption of a standardized amount of filtered tap water improved the self-reported physical complaints. However, since individuals were fully aware of the type of water they consumed it was unclear to what extent this effect was ascribable to placebo effects. This paper tests the effectiveness of an in-home water filter system (AcalaQuell®) which was compared with a sham water filter containing no significant filter ingredients. Both filters were concealed, and participants knew that the probability to receive the clinically proven filter was 50 percent. There were large differences between the two groups (d = 0.7 < d < 2). For individual-specific complaints, the reduction was 38 percent for the filtered water group while the reduction in the placebo group was about 8 percent. Subjective health complaints are considerably reduced after daily intake of AcalaQuell®-filtered tap water during a three-week administration period. This effect is specific and independent from placebo effects.
Balancing WTO-TRIPS Standard Against Nigeria Counterfeit Regulatory Efforts
Authors: Imasuen Ifueko Itohan , Nwajana Augustine O.
Published: April 2022

Recent years has seen the rapid growth and scale of Counterfeit Pharmaceuticals in Nigeria irrespective of the Intellectual Property Right (IPR) standard provided by the World Trade Organisation-Trade Related aspect of Intellectual Property Right (WTO-TRIPS) Agreement. The effect of the WTO-TRIPS protection of Intellectual Property Rights creates the problem of access to medicine for developing countries. This has provoked counterfeit pharmaceutical activities worldwide and prevalently in Nigeria. The aim is to ascertain, by way of analytical framework the viability of the WTO-TRIPS agreement for addressing the scourge of counterfeit pharmaceuticals in Nigeria. The concept of counterfeit pharmaceuticals will be explored, and its parameters defined as a premise for testing the viability of the WTO-TRIPS and the Nigerian Counterfeit regulatory framework.
Linkage Between Culture, Leadership, and Knowledge Sharing in MNCs
Authors: Rahman Safayet , Hossain Munir , Islam Md. Zahidul , Jasimuddin Sajjad M.
Published: April 2022

The paper develops a theoretical model that focuses on the integrated effect of organizational factors on knowledge sharing, taking the moderating effect of training and development. The proposed hypotheses were tested with structural equations modeling using self-reports of 200 personnel working in Bngladesh-based MNCs. The organizational factors such as respect for people, job stability, aggressiveness, transformational leadership, transactional leadership and decentralization have a direct influence on knowledge sharing. The substantial effect of training and development was not evident in moderating the relationship between organizational factors and knowledge sharing. However, this study reveals that training and development moderates only the relationship between team orientation and knowledge sharing. the findings broaden the understanding of the impact of organizational culture, leadership, and training and development, and knowledge sharin. This study helps managers to formulate strategies and provide new knowledge to researchers to look further into this field.
The proportionality of merger remedies in differentiated product markets
Authors: März Oliver , Tosini Nicola
Published: April 2022

Horizontal mergers that raise competition concerns may require divestitures that eliminate the identified concerns. At the same time, divestitures should be proportionate, not going above and beyond what is necessary to eliminate the identified concerns. In this article, we argue that in differentiated product markets out-of-market substitutes exert stronger competitive pressure on some products within the relevant product market than on others. As a result, a divestiture of products that are subject to strong competitive pressure from out-of-market substitutes may not be needed if other products that are subject to weaker competitive pressure are divested. A simplistic solution that requires divestitures in all areas of horizontal overlap could result in overly broad remedies that violate the proportionality principle.
CLIMA ORGANIZACIONAL Y ESTRÉS LABORAL EN TRABAJADORES DEL DISTRITO DE EDUCACIÓN, MANTA, MONTECRISTI, JARAMIJÓ
Authors: Bailón-González César Augusto , Cedeño-Zambrano Rosa Maricela
Published: April 2022

En el contexto laboral el clima organizacional y estrés laboral juega un papel preponderante para el correcto desarrollo de las empresas, por ende, se debe tomar en cuenta que es un tema de mucha relevancia para las entidades tanto públicas como privadas, siendo el ministerio de educación y sus distritos, partes principales ya que cumplen funciones vitales en la formación académica de jóvenes y niños. Sin embargo, atrás de las funciones de vital importancia que llevan a cabo los distritos tenemos al equipo de talento humano, colaboradores de trabajo, que se encuentran desempeñando diversas funciones a través de cada puesto en la organización. El departamento de talento humano cumple varias funciones en las entidades, entre estas se encuentra la medición del clima organizacional, por lo tanto, también le corresponde tomar medidas correctivas a aplicar para la reducción del estrés laboral. Por consiguiente, la presente investigación tuvo como finalidad evaluar el clima organizacional y el estrés laboral en los trabajadores del distrito de educación, Manta, Montecristi, Jaramijó, provincia de Manabí en el año 2020. Para ello, se empleó una metodología cuantitativa, con un enfoque no experimental, de tipo descriptiva, documental y de campo. Entre los principales resultados se destaca que las supresiones de partidas, así como los avances tecnológicos han provocado en el personal administrativo y educativo un ambiente de trabajo tenso, que se traduce en un estrés laboral que en ciertas ocasiones está mermando el logro de los objetivos institucionales.

Palabras claves: Clima organizacional, estrés laboral, educación, trabajadores.
AUDITORÍA DE GESTIÓN AMBIENTAL A LOS DESECHOS DEL HOSPITAL DE ESPECIALIDADES DE PORTOVIEJO, 2020
Authors: Cabrera-Pinargote Martha Beatriz , Vélez-Mendoza Leither Pamela
Published: April 2022

Los remanentes de las actividades hospitalarias originan incontables vestigios negativos en el contexto que repercute en el entorno ya sea a corto, mediano o largo plazo. En este sentido, el presente artículo de investigación, se desarrolla con el objetivo de evaluar el proceso de auditoría a la gestión ambiental a los desechos del Hospital de Especialidades de Portoviejo, enmarcado en una metodología de diseño no experimental, con un enfoque mixto y de tipo exploratoria, descriptivos, de campo y bibliográficos. Aplicando el cuestionario y la entrevista como técnica de recolección de datos dirigida a 7 personas que conforman la muestra del estudio. Entre los principales resultados obtenidos en la investigación se destacan las deficiencias ambientales dentro del Hospital de Especialidades de Portoviejo, al no contar con un profesional en el campo de la ingeniería ambiental y al no existir evidencia de auditorías ambientales realizadas para evaluar los riesgos inherentes a esta actividad. Esta situación genera una problemática que puede incurrir en grandes impactos negativos para el hospital y el entorno ya que la actividad de estos establecimientos genera incidencias en el entorno que sin un procesamiento acorde podrían suscitar peligros latentes contra el bienestar del individuo y su contexto; por consiguiente, se asume que es preciso efectuar una política de gestión ambiental hospitalaria. Se recomienda tomar las acciones requeridas para formular políticas que se enfoquen en la prevención de riesgos ambientales, a través de auditorías evaluativas que promuevan un eficiente manejo de los residuos y el cuidado del ambiente.

Palabras claves: Auditoria, gestión, desechos, hospital, ambiente.
Promoting Workplace Innovation in an Innovation Policy Context
Authors: Alasoini Tuomo
Published: April 2022

The wider societal impact of workplace innovation development programmes has typically been limited by their poor ability to scale up project outcomes and disseminate good practice. Researchers have proposed different means to address the challenges of diffusion. One of the suggested means is to strengthen the integration of programmes to industrial or innovation policy frameworks, instead of an industrial relations framework. Using the “Finnish Liideri – Business, Productivity and Joy at Work” (2012–18) programme as an object of analysis, this article examines what added value the programme’s attachment to the innovation policy context brought compared to previous Finnish programmes and to what extent this attachment helped to bring new solutions to the challenges of diffusion. The analysis shows that the Liideri programme included many new features compared to previous Finnish programmes, opening up opportunities for more holistic development work in companies. However, based on the data available, it was not possible to give a clear answer to the question of the real added value of this integration to the development of companies or compared with the results of projects funded by previous Finnish workplace innovation development programmes. Concerning the question on dissemination of good practice, the article concludes that, despite its large-scale and high-quality activation work, the Liideri programme did not include sufficiently efficient and innovative measures that would have enabled it to meet better the challenges of diffusion.
A New Health and Care System
Authors: Fox Alex
Published: April 2022

This book outlines a new, human focussed model for public services - an approach focused on achieving and maintaining wellbeing, rather than on reacting to crisis or attempting to ‘fix’ people.
Natural and anthropogenic sources of atmospheric air pollution by asbestos fibers
Authors: Tskhomariia Iraklii M. , Kovalevskiy Evgeny V. , Kashanskiy Sergey V.
Published: April 2022

Introduction. Deposits of various types of asbestos are widespread in the earth’s crust. In these areas there may be a possibility of the atmospheric air pollution by asbestos fibers, especially in the case of industrial development of these deposits or active use by the resident population. The purpose of this study was to assess the possibility of air pollution by amphibole asbestos fibers in the areas of disused flooded quarries in Sverdlovsk region. Materials and methods. 5 samples of atmospheric air, water and soil were taken and analyzed at the territories in Sverdlovsk region where magnesio-arfvedsonite and anthophyllite were extracted in the past years. Results. An extremely high content of free fibers of magnesio-arfvedsonite and anthophyllite (up to 20% of the total weight of the samples) was discovered in the soil samples. The concentrations of asbestos fibers in the water averaged 67∙10 6 f/L and 79∙10 6 f/L, respectively. The average concentrations of respirable amphibole asbestos fibers were 0.06 f/ml and 0.05 f/ml, respectively. Limitations. The paper presents the results of a pilot study of air pollution by fibrous particles, based on which it is not possible to give a full description of the situation, taking into account all possible types of anthropogenic activity in the surveyed areas in different seasons of the year. Conclusion. The results obtained indicate an increased risk of air pollution and water environment contamination by free amphibole asbestos fibers due to their leaching and weathering from rocks, as a result of which disused flooded quarries should be considered as natural and anthropogenic sources of pollution. It is necessary to conduct regular monitoring of the environmental situation at these facilities, as well as to develop measures to prevent the exposure of amphibole asbestos fibers on the population.
Leadership Theories: Application in the University Setting
Authors: Alajmi Meaad
Published: April 2022

The paper discusses the application of three major theories of leadership in the education field. The paper starts with the trait theories and the possibility of its application in the education system from the highest position down to the teacher classroom.  The second theory this paper sheds light on is the situational leadership theory. It looks into the literature regarding its application in the same system, i.e. education. The last theory this paper discusses is the contingency theory. It showcases the definition of the theory and the literature around its application in the educational system. The paper finally concludes that all theories are applicable according to the literature and research made on the topic.
Repair organisations in English as second language classrooms in a Ghanaian Technical University
Authors: Bukari Francis , Asafo-Adjei Ramos , Klu Ernest Kwesi
Published: April 2022

Communication breakdowns usually occur in teaching and learning interactions, necessitating repair. This study investigated the types of conversation repair organisations utilised by both lecturers and students during classroom interaction at the Takoradi Technical University. The study adopted the Conversation Analysis (CA) theory as a framework and methodology. The repair organisations identified in the study included self-initiated self-repair, self-initiated other-repair and other-initiated self-repair.  Also, during classroom interaction, lecturers and students use paralinguistic elements such silence, cupping of the ear and smiling to convey their feelings and thoughts. Some implications of the study are that university lecturers should repair in their classroom interactions to make them more aware of communication breakdowns and what to do when there are issues with comprehensibility and intelligibility. Additionally, they have to design courses that will educate students on the application of various types of repair organisations and paralinguistic features in classroom discourse to engender effective communication.
The Evolutionary Course of Theory of Mind – Factors that facilitate or inhibit its operation & the role of ICTs
Authors: Bamicha Victoria , Drigas Athanasios
Published: April 2022

The Theory of Mind is a bridge of mental understanding between us and others. Its proper functioning provides opportunities for communication, effective social interaction, development on a cognitive and metacognitive level. The present study aims to examine its developmental stages from infancy to adolescence, as well as the main factors that stimulate or defeat its course. The crucial development of executive skills, language function, and the importance of the role of ICTs is pointed out, as they compensate for the difficulties in the formation of Theory of Mind and promote its continuous improvement throughout an individual's life.