bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring the use of bimodal transcranial direct current stimulation to enhance movement in individuals with patellofemoral pain—A sham-controlled double blinded pilot study
Authors: Ho Kai-Yu , Wallace Connan , Aquino Jeno , Broadwell Bryce , Whimple Makenzie , Liang Jing Nong
Published: September 2024

Introduction

In individuals with patellofemoral pain (PFP), addressing increased knee valgus during weight-bearing activities typically involves strengthening weak hip muscles. However, recent literature highlights the role of altered descending central control in abnormal movements associated with PFP. While transcranial direct current stimulation (tDCS) has demonstrated the capacity to enhance neuroplasticity, its application targeting the corticomotor function of gluteal muscles in PFP remains unexplored. This study aimed to investigate the effects of combining bimodal tDCS with exercise on frontal plane kinematics in individuals with PFP. The hypothesis was that bimodal tDCS, specifically targeting the corticomotor function of the gluteal muscles, would augment the effectiveness of exercise interventions in improving frontal plane kinematics compared to sham stimulation.

Methods

Ten participants with PFP participated in two sessions involving either bimodal tDCS or sham stimulation, concurrently with hip strengthening exercises. Weight-bearing tasks, including single leg squat, single leg landing, single leg hopping, forward step-down, and lateral step-down, were performed and recorded before and after each session. Pain visual analog scale (VAS) scores were also documented. A one-way ANOVA with repeated measures was employed to compare kinematics, while a Friedman test was used to compare VAS across the three conditions (pre-test, post-tDCS, and post-Sham).

Results

We observed no significant differences in trunk lean angle, hip and knee frontal plane projection angles, or dynamic valgus index among the three conditions during the five weight-bearing tasks. VAS scores did not differ across the three conditions.

Discussion and conclusion

A single session of tDCS did not demonstrate immediate efficacy in enhancing frontal plane kinematics or relieving pain in individuals with PFP. Considering observed positive outcomes in other neurological and orthopedic populations with multi-session tDCS applications, suggesting potential cumulative effects, further research is essential to explore the effects of multi-session tDCS on weight-bearing movement and underlying neurophysiology in individuals with PFP.
Hepatocellular carcinoma cells induce γδ T cells through metabolic reprogramming into tumor-progressive subpopulation
Authors: Xia Jinkun , Wang Chaoyu , Li Biao
Published: September 2024

Tumor immune microenvironment (TIME) is a tiny structure that contains multiple immune cell components around tumor cells, which plays an important role in tumorigenesis, and is also the potential core area of activated immunotherapy. How immune cells with tumor-killing capacity in TIME are hijacked by tumor cells during the progression of tumorigenesis and transformed into subpopulations that facilitate cancer advancement is a question that needs to be urgently addressed nowadays. γδ T cells (their T cell receptors are composed of γ and δ chains), a unique T cell subpopulation distinguished from conventional αβ T cells, are involved in a variety of immune response processes through direct tumor-killing effects and/or indirectly influencing the activity of other immune cells. However, the presence of γδ T cells in the tumor microenvironment (TME) has been reported to be associated with poor prognosis in some tumors, suggesting that certain γδ T cell subsets may also have pro-tumorigenic effects. Recent studies have revealed that metabolic pathways such as activation of glycolysis, increase of lipid metabolism, enhancement of mitochondrial biosynthesis, alterations of fatty acid metabolism reshape the local TME, and immune cells trigger metabolic adaptation through metabolic reprogramming to meet their own needs and play the role of anti-tumor or immunosuppression. Combining previous studies and our bioinformatics results, we hypothesize that γδT cells compete for resources with hepatocellular carcinoma (HCC) cells by means of fatty acid metabolic regulation in the TME, which results in the weakening or loss of their ability to recognize and kill HCC cells through genetic and epigenetic alterations, thus allowing γδT cells to be hijacked by HCC cells as a subpopulation that promotes HCC progression.
Strategies for engineering oncolytic viruses to enhance cancer immunotherapy
Authors: Yin Ziyang (Steve) , Wang Zhengfeng
Published: September 2024

Non-small cell lung cancer (NSCLC) is the predominant form of lung cancer and is characterized by rapid metastasis and high mortality, presenting a challenge for early-stage treatment modalities. The heterogeneity of NSCLC’s tumor microenvironment (TME) significantly influences the efficacy of anti-PD-1 immune checkpoint inhibitors (ICIs) therapy, leading to varied patient responses. This review characterized different strains of oncolytic viruses in NSCLC and the different gene edits in pre-existing oncolytic viruses. This study also aimed to provide strategies to enhance anti-PD-1 therapy in NSCLC by engineering oncolytic viruses (OVs). This study offers insights into the genomic adaptations necessary for OVs targeting NSCLC, identify genetic determinants of anti-PD-1 response variability, and propose genomic edits to bolster therapy effectiveness. The primary goal of this study is to present a theoretically designed OV with a detailed genomic framework capable of enhancing the response to anti-PD-1 therapy, thereby advancing the field of cancer immunotherapy.
Life course and mental health: a thematic and systematic review
Authors: Zhang Yuhu , Shaojun Chen , Akintunde Tosin Yinka , Okagbue Ekene Francis , Isangha Stanley Oloji , Musa Taha Hussein
Published: September 2024

Objective

This study explored the influence of the life course on mental health by identifying key trends, seminal works, and themes in existing research. Additionally, it highlights the major discussions at the intersection of life course and mental health.

Methods

Documents were extracted from the Web of Science Core Collection (WoSCC), to systematically analyze themes on mental health outcomes across the life course. The analysis was based on key bibliometric tools, including VOSviewer 1.6.11, R Studio software, and GraphPad Prism 9 to analyze the evolution and impact of scholarly contributions in this domain.

Results

The accumulated body of research concerning the life course’s impact on mental health, which began to emerge around 1990 displayed a consistently upward trend. Predominant contributions originate from developed nations and frequently look into the psychosocial determinants of mental health over life course. Life course and mental health studies have been extensively infused with biopsychosocial frameworks that consider the role of genetic makeup, neurodevelopment, cognition, affect, sociocultural dynamics, and interpersonal relationships. Life course theory application in mental health highlight the substantive effects of accumulated adversities, notably social determinants of health, adverse childhood experiences (ACEs), and their implications for subsequent mental health outcomes.

Conclusion

The nexus of life course and mental health outcomes demands further scholarly interrogation, particularly within underserved regions, to strengthen protective mechanisms for vulnerable populations.
The effects of mindfulness enhanced Tai Chi Chuan training on mental and physical health among beginners: a randomized controlled trial
Authors: Qu Ping , Zhu Xiaoqing , Zhou Hui , Kang Zhengyu , Li Ran , Wen Jingsi , Pan Feng , Liu Yang , Zhu Ting , Cao Qian , Wang Xiaoyan , Wang Yuyin
Published: September 2024

Introduction

Tai Chi Chuan (TCC) is a traditional Chinese mind–body exercise widely adopted in Chinese communities and colleges. However, the mindful essence of TCC is rarely emphasized during popularization. This makes it difficult for beginners to benefit from it. The present study aimed to examine the effects of a Mindfulness-enhanced Tai Chi Chuan (MTCC) intervention, which enhances mindfulness components embedded within TCC, on mental and physical health among beginners.

Methods

A randomized controlled trial was conducted with 119 healthy college students new to Tai Chi Chuan training. Participants were assigned to either the MTCC group or the TCC group. Both interventions consisted of 10 weekly 90-min training sessions, with the MTCC group emphasizing and enhancing mindfulness components. Outcome measures included mindfulness, depression, anxiety, stress, and physical fitness, assessed at baseline and post-intervention.

Results

The results showed that the MTCC group had significantly greater improvements than the TCC group in mindfulness, anxiety, stress, and health—and skill-related physical fitness. There were no significant differences between the two groups in depression.

Conclusion

The findings suggest that compared to TCC, MTCC can effectively promote individuals’ physical fitness and provide additional benefits to mental well-being. MTCC can be recommended as an accessible and beneficial intervention for beginners to improve mental health and strengthen their bodies.

Clinical review registration

https://www.chictr.org.cn/, identifier ChiCTR2200058175.
Religion, culture, and cancer: insights from a qualitative study on coping experiences of Filipino patients
Authors: Ahmadi Fereshteh , Zandi Saeid , Poblete Mae-Lanie
Published: September 2024

Introduction

Meaning-making coping is used by people with cancer to help them deal with the stress and emotional turmoil associated with their diagnosis. It is a multifaceted approach that can be influenced by cultural, existential, and personal factors. Research on meaning-making coping among Filipinos diagnosed with cancer is sparse. This study examines how a sample of Filipino people with cancer cope with their illnesses.

Methods

We employed a qualitative approach. The study involved 20 participants with various types of cancer in the Philippines who were selected through purposive sampling and agreed to be interviewed.

Results

The thematic analysis of the interviews revealed the application of both religious and secular meaning-making coping by participants. The study also confirmed the potential influence of culture on coping strategies.

Discussion

The results indicate that religion plays a significant role in Filipino coping mechanisms, given that the Philippines is predominantly a Christian nation. Additionally, the findings highlight the importance of close family ties in Filipino culture and how it contributes to coping with cancer.
Suicidal ideation following internet-delivered tailored CBT for depression – a secondary analysis of a factorial design trial
Authors: Käll Anton , Andersson Gerhard
Published: September 2024

Introduction

Suicidal ideation is common in major depressive disorder (MDD) and a risk factor for suicidal behavior. Although it can be reduced with psychological treatments, the risks often make clinicians hesitant to offer treatment. This concerns remote treatment options, such as internet-delivered cognitive behavior therapy (ICBT), which may be considered unsafe. Although previous studies indicate that ICBT can reduce self-reported suicidal ideation both as primary and indirect treatment target, questions remain about under what circumstances ICBT can be offered as the primary treatment. In this secondary report, we investigated the importance of different treatment factors in reducing suicidal ideation via ICBT, including different kinds of therapist support.

Methods

We analyzed data from 197 participants from a factorial trial of ICBT for symptoms of MDD. Before inclusion all participants completed a structured clinical interview where obvious suicidal intent lead to exclusion. Suicidal ideation was assessed at pre- and posttreatment using one item of the PHQ-9 and one from BDI-II. The data were analyzed using generalized linear models.

Results

The pre- to posttreatment comparisons showed decreases in the reporting of suicidal ideation. Findings were consistent across the two measures that was used. There was no effect of support format and content tailoring.

Conclusions

The findings suggest that ICBT can help alleviate suicidal ideation even when it is not the focus of the treatment. This was the case regardless of mode of therapist support, who tailored the treatment content, and if case supervision was available or not.
The impact of a 12-week tele-exercise program on cognitive function and cerebral oxygenation in patients with OSA: randomized controlled trial—protocol study
Authors: Stavrou Vasileios T. , Pitris Konstantinos , Constantinidou Fofi , Adamide Tonia , Frangopoulos Frangiskos , Bargiotas Panagiotis
Published: September 2024

Obstructive sleep apnea (OSA) is associated with a number of adverse health effects, particularly on brain health. Chronic sleep disruption caused by OSA can adversely affect cognitive health. Exercise is recommended as a non-pharmacological intervention for patients who are intolerant to continuous positive airway pressure (CPAP) and has been shown to have beneficial effects on brain health and cognitive function. This protocol aims to investigate the effects of a 12-week tele-exercise program on cognitive function and specific parameters of brain activity, including brain metabolism and oxygenation, in patients with OSA. The project aims to demonstrate the multidimensional relationship between exercise, cognition, and brain oxygenation/metabolism. Our local ethics committee has approved the study. Our population sample (Group A, OSA with cognitive impairment (CI) and tele-exercise; Group B, OSA with CI and no tele-exercise; Group C, OSA without CI and no tele-exercise) will undergo assessment both before and after a 12-week tele-exercise intervention program. This assessment will include a comprehensive battery of subjective and objective assessment tests. Data will be analyzed according to group stratification. We hypothesize a beneficial effect of tele-exercise on sleep and cognitive parameters, and we are confident that this study will raise awareness among healthcare professionals of the brain health benefits of exercise in patients with low compliance to CPAP treatment. The protocol of our manuscript entitled "The impact of a 12-week tele-exercise program on cognitive function and cerebral oxygenation in patients with OSA: Randomized Controlled Trial -Protocol Study" has been registered on ClinicalTrials.gov with ID NCT06467682.
Correspondence between the Simple Physical Activity Questionnaire (SIMPAQ) and accelerometer-based physical activity in inpatients treated for major depressive disorders in comparison to non-depressed controls
Authors: Schilling René , Cody Robyn , Kreppke Jan-Niklas , Faude Oliver , Beck Johannes , Brand Serge , Donath Lars , Hatzinger Martin , Imboden Christian , Lang Undine , Mans Sarah , Mikoteit Thorsten , Oswald Anja , Schweinfurth-Keck Nina , Gerber Markus
Published: September 2024

Introduction

Major depressive disorders (MDD) are a leading health concern worldwide. While first line medication treatments may fall short of desired therapeutic outcomes, physical activity (PA) interventions appear to be a promising and cost-effective add-on to improve symptoms of depression. This study aimed to address challenges in the assessment of PA in inpatients treated for MDD by examining the correspondence of self-reported and accelerometer-based PA.

Methods

In 178 inpatients treated for MDD (mean age: M = 41.11 years, SD = 12.84; 45.5% female) and 97 non-depressed controls (mean age: M = 35.24 years, SD = 13.40; 36.1% female), we assessed self-reported PA via the Simple Physical Activity Questionnaire (SIMPAQ) for one week, followed by a week where PA was monitored using an accelerometer device (Actigraph wGT3x-BT). Additionally, we examined correlations between PA levels assessed with the SIMPAQ and exercise determinants in both groups.

Results

Descriptively, inpatients treated for MDD showed lower levels of light PA on accelerometer-based measures, whereas they self-reported increased levels of certain types of PA on the SIMPAQ. More importantly, there was only a small degree of correspondence between self-reported and actigraphy-based PA levels in both in patients (r = 0.15, p < 0.05) and controls (r = 0.03, ns). Only few significant correlations were found for self-reported PA (SIMPAQ subscores) and perceived fitness, whereas self-reported PA and estimated VO2max were unrelated. Furthermore, only weak (and mostly statistically non-significant) correlations were found between exercise determinants and SIMPAQ-based exercise behavior in both populations.

Discussion

Our findings emphasize the intricate challenges in the assessment of PA, not only in inpatients treated for MDD, but also in non-depressed controls. Our findings also underline the necessity for a diversified data assessment. Further efforts are needed to refine and improve PA questionnaires for a more accurate data assessment in psychiatric patients and healthy controls.
Food safety and hygiene knowledge, attitudes and practices in street restaurants selling chicken in Ouagadougou, Burkina Faso
Authors: Gemeda Biruk Alemu , Dione Michel , Ilboudo Guy , Assefa Ayalew , Lallogo Valerie , Grace Delia , Knight-Jones Theodore J. D.
Published: September 2024

Introduction

Chicken is the most commonly consumed animal source food in street restaurants in Burkina Faso. In most of these restaurants, slaughtering, processing, and cooking practices are carried out under poor hygienic conditions.

Methods

A cross-sectional survey using a semi-structured interview was carried out to assess food safety knowledge, attitude, and hygienic practices of food handlers in street restaurants selling chicken in Burkina Faso’s capital, Ouagadougou. One hundred chicken restaurants were randomly selected, and food handlers were interviewed.

Results and discussion

Most restaurants served eat-in and takeaway chicken (66%); the remaining 34% were takeaway only; restaurants served grilled, flamed or roasted chicken. Only 11% of the food handlers had training on food hygiene and safety. Half the outlets were not regularly inspected by the authorities. Less than half (40%) slaughtered their own chickens at the restaurant: of these 85% bled chickens on bare earth. About 80% cleaned the bleeding surface immediately after slaughter with water but only 20% used water with either soap or disinfectant detergent. Eighty-two percent of them used the same cloth during slaughtering and food preparation stages. Many used the same knife in all stages of the slaughtering process. Two-thirds kept carcasses unrefrigerated at ambient temperature until cooking started. Around a quarter buried slaughter waste on-site whereas 20% disposed of it on the street near the restaurant. Only 20% had taken steps to improve food safety, and about 80% of food handlers stated that cleanliness and hygiene were not important to their customers when choosing where to eat. Almost half (42%) the food handlers continued to work when they were ill. The poor standards of hygiene observed are typical for street food and small-scale eateries in LMICs in Sub Saharan Africa. An integrated approach is required to improve the situation, including staff training, introduction of food-grade equipment and appropriate technology, behavior-change approaches, as well as worker and consumer awareness campaigns on good food safety practices. However, significant, sustained improvement in food safety will also require major upgrading of infrastructure and facilities including power and water supply, and cold chain.
Positive Impact of UV Photography on Individual Sun Protection: A Swiss Feasibility Study
Authors: Corre Tanguy , Zimmermann Kathrine , Gaide Olivier , Vernez David , Bulliard Jean-Luc
Published: September 2024

Objectives

This study evaluates the feasibility and impact of conveying personalized sun protection message supported by a UV photograph of the face in Switzerland.

Methods

440 adults from 14 private and public sites associated with high sun exposure received a skin cancer prevention intervention composed of a facial UV-filtered photograph and individual counselling by a trained registered nurse. Pre-/post intervention surveys assessed sun protection of participants, their skin cancer risk and reasons for behavioural change.

Results

The range of facial UV spots’ count per individual was very broad (0–590) and mainly determined by phototype, followed by age. Three months after the intervention, 61% of participants positively changed their sun protection habit both during leisure and at work. Use of all sun protection means increased. No factor could be specifically associated to that propension for change. The individualized message was perceived as the main motivation for change.

Conclusion

Personalized sun protection messages supported by a facial UV photograph led to significant favourable behavioural change in a highly sun-exposed population of adults.
Barriers and Facilitators Related to Undertaking Physical Activities in Colorectal Cancer Patients: A Scoping Review
Authors: Yan Hu , Shuying Chang , Yuege Li , Han Kong
Published: September 2024

Background:

Colorectal cancer (CRC) and its treatments cause significant acute, chronic, or latent adverse effects, leading to decreased physical function and quality of life. Robust evidence supports the positive effects of physical activity (PA) on various health outcomes in CRC patients. However, there is limited understanding regarding the factors that influence PA engagement, including facilitators, preferences, and barriers in this population.

Purpose:

This scoping review aims to document the breadth and depth of literature concerning the various aspects of PA participation among patients with CRC. We conducted a scoping review of PA among CRC patients.

Methods:

We searched several databases, including PubMed, Web of Science, Embase, and Cochrane, from their inception to 25 July 2023. Multiple reviewers were involved in all screening and data abstractions. The search yielded 834 individual citations after removing duplicates. After screening the titles and abstracts, 20 articles underwent full-text review, and 11 were included.

Results:

Our research findings indicate that among CRC patients, the most prevalent facilitators/preferences for PA are understanding its importance and perceiving its benefits, whereas treatment-related effects and lack of time are the most common barriers.

Conclusion:

CRC patients have unique facilitators and barriers concerning PA. Further research and clinical interventions are required to support and encourage this population to participate in and maintain regular PA.
The Relative Risk of COVID-19 in Solid Organ Transplant Recipients Over Waves of the Pandemic
Authors: Vinson Amanda J. , Anzalone Alfred J. , Schissel Makayla , Dai Ran , Agarwal Gaurav , Lee Stephen B. , Olex Amy , Mannon Roslyn B.
Published: September 2024

Solid organ transplant recipients (SOTR) are at increased risk from COVID-19. Over time, the absolute risk of adverse outcomes after COVID-19 has decreased in both the non-immunosuppressed/immunocompromised (non-ISC) general population, and amongst SOTR. Using the N3C, we examined the absolute risk of mortality, major adverse renal or cardiac events, and hospitalization after COVID-19 diagnosis amongst non-ISC and SOTR populations over five waves of the pandemic (Wave 1: Ancestral COVID; Wave 2: Alpha; Wave 3: Delta; Wave 4: Omicron; Wave 5: Omicron). Within each wave, we determined the relative risk of each outcome for SOTR versus the non-ISC population based on crude event rates, and then used multivariable cox proportional hazards models and logistic regression to determine the adjusted risk of each outcome based on SOT status. Throughout the pandemic, including during the Omicron wave (Wave 5), SOTR were at greater absolute risk for each outcome than non-ISC patients (p-values all <0.001). The adjusted risk of SOT status for each outcome was relatively stable over time (aHR 1.28–1.61 for mortality; aHR 1.31–1.47 for MACE; aHR 1.72–1.90 for MARCE; aHR 1.75–2.07 for AKI; and aOR 1.53–1.81 for hospitalization). Despite a reduction in the absolute risk of COVID-19 complications, the relative risk for SOTR versus the non-ISC population has not improved.
In-Depth Insights into the Application of Recurrent Neural Networks (RNNs) in Traffic Prediction: A Comprehensive Review
Authors: He Yuxin , Huang Ping , Hong Weihang , Luo Qin , Li Lishuai , Tsui Kwok-Leung
Published: September 2024

Traffic prediction is crucial for transportation management and user convenience. With the rapid development of deep learning techniques, numerous models have emerged for traffic prediction. Recurrent Neural Networks (RNNs) are extensively utilized as representative predictive models in this domain. This paper comprehensively reviews RNN applications in traffic prediction, focusing on their significance and challenges. The review begins by discussing the evolution of traffic prediction methods and summarizing state-of-the-art techniques. It then delves into the unique characteristics of traffic data, outlines common forms of input representations in traffic prediction, and generalizes an abstract description of traffic prediction problems. Then, the paper systematically categorizes models based on RNN structures designed for traffic prediction. Moreover, it provides a comprehensive overview of seven sub-categories of applications of deep learning models based on RNN in traffic prediction. Finally, the review compares RNNs with other state-of-the-art methods and highlights the challenges RNNs face in traffic prediction. This review is expected to offer significant reference value for comprehensively understanding the various applications of RNNs and common state-of-the-art models in traffic prediction. By discussing the strengths and weaknesses of these models and proposing strategies to address the challenges faced by RNNs, it aims to provide scholars with insights for designing better traffic prediction models.
Stiffness Analysis of Cable-Driven Parallel Robot for UAV Aerial Recovery System
Authors: Wu Jun , Yue Honghao , Pan Xueting , Wang Yanbing , Zhao Yong , Yang Fei
Published: September 2024

Unmanned Aerial Vehicle (UAV) aerial recovery is a challenging task due to the limited maneuverability of both the transport aircraft and the UAV, making it difficult to establish an effective capture connection in the airflow field. In previous studies, we proposed using a Cable-Driven Parallel Robot (CDPR) for active interception and recovery of UAVs. However, during the aerial recovery process, the CDPR is continuously subjected to aerodynamic loads, which significantly affect the stiffness characteristics of the CDPR. This paper conducts a stiffness analysis of a single cable and a CDPR in a flow field environment. Firstly, we derive the stiffness matrix of a single cable based on a model that considers aerodynamic loads. The CDPR is then divided into elements using the finite element method (FEM), and the stiffness matrix for each element is obtained. These element stiffness matrices are assembled to form the stiffness matrix of the CDPR system. Secondly, we analyze the stiffness distribution of a single cable at various equilibrium positions within a flow field environment. Aerodynamic loads were observed to alter the equilibrium position of the cable, thereby impacting its stiffness. The more the cable bends, the greater the reduction in its stiffness. We examine the stiffness distribution characteristics of the CDPR’s end-effector within its workspace and analyze the impact of varying flow velocities and different cable materials on the system’s stiffness. This research offers a methodology for analyzing the stiffness of CDPR systems operating in a flow field environment.
Research on Lower Limb Exoskeleton Trajectory Tracking Control Based on the Dung Beetle Optimizer and Feedforward Proportional–Integral–Derivative Controller
Authors: Li Changming , Di Haiting , Liu Yongwang , Liu Ke
Published: September 2024

The lower limb exoskeleton (LLE) plays an important role in production activities requiring assistance and load bearing. One of the challenges is to propose a control strategy that can meet the requirements of LLE trajectory tracking in different scenes. Therefore, this study proposes a control strategy (DBO–FPID) that combines the dung beetle optimizer (DBO) with feedforward proportional–integral–derivative controller (FPID) to improve the performance of LLE trajectory tracking in different scenes. The Lagrange method is used to establish the dynamic model of the LLE rod, and it is combined with the dynamic equations of the motor to obtain the LLE transfer function model. Based on the LLE model and target trajectory compensation, the feedforward controller is designed to achieve trajectory tracking in different scenes. To obtain the best performance of the controller, the DBO is utilized to perform offline parameter tuning of the feedforward controller and PID controller. The proposed control strategy is compared with the DBO tuning PID (DBO–PID), particle swarm optimizer (PSO) tuning FPID (PSO–FPID), and PSO tuning PID (PSO–PID) in simulation and joint module experiments. The results show that DBO–FPID has the best accuracy and robustness in trajectory tracking in different scenes, which has the smallest sum of absolute error (IAE), mean absolute error (MEAE), maximum absolute error (MAE), and root mean square error (RMSE). In addition, the MEAE of DBO–FPID is lower than 1.5 degrees in unloaded tests and lower than 3.6 degrees in the hip load tests, with only a few iterations, showing great practical potential.
The Design and Analysis of Reinforcement Schemes for Pultruded Rod Stitched Efficient Unitized Structure Open-Panel Structures
Authors: Zhang Yongjie , Zhang Tongxin , Zhou Jingpiao , Cui Bo , Chen Fangyu
Published: September 2024

This paper presents the design and analysis of PRSEUS structures with no openings, small openings, and mid-sized openings. For the typical panel structure of the small-opening PRSEUS (Pultruded Rod Stitched Efficient Unitized Structure), five reinforcement schemes are developed using different types, such as mouth frames and convex platforms. Simulation analyses of tensile and compressive load are conducted. Compared to the non-opening PRSEUS panel, the small-opening PRSEUS panel’s maximum von Mises stress increases by 4.57 times under uniaxial tensile load, and the maximum von Mises stress increases by 2.55 times under uniaxial compressive load. The reinforcement efficiency of the small-opening PRSEUS panel in all five schemes exceeded 30%, Scheme E exhibits the highest load-bearing efficiency under both tensile and compressive load conditions, at 673.63 MPa/kg and 503.38 MPa/kg, respectively. For the typical PRSEUS panel structure with a mid-sized opening, three reinforcement schemes are proposed based on different methods, such as grid and cross-shaped reinforcement. These address the impact of mid-sized openings on the bearing capacity of the PRSEUS pane by analyzing the bearing efficiency of the three schemes. Compared to the non-opening PRSEUS panel, the maximum von Mises stress increases by 15.22 times under a uniaxial tensile load and by 32.45 times under a uniaxial compressive load. The reinforcement efficiency of the mid-sized-opening PRSEUS panel in these three schemes is greater than 50%, with Scheme III providing the highest bearing efficiency under a tensile load at 20.74 MPa/kg and 50.66 MPa/kg under a compressive load.
Effect of Gurney Flaps on Non-Planar Wings at Low Reynolds Number
Authors: Traub Lance W.
Published: September 2024

The effect of spanwise wing non-planarity, employed in conjunction with a Gurney flap, is presented. Testing was undertaken in a low-speed wind tunnel using a rectangular wing with an aspect ratio of three. The outer one-third of the wing was non-planar, which took the form of either dihedral or a circular arc. A 2% high Gurney flap was implemented such that it could extend over the entire span or the planar inboard section. The loads were measured using a sting balance. The data show that non-planarity increases the maximum lift coefficient and the wing’s lift curve slope. Gurney flap lift modulation was enhanced in the presence of non-planarity. The addition of Gurney flaps caused a greater increment in the minimum drag coefficient for the non-planar wings. The Gurney flaps reduced the lift-dependent drag of the wings. As a whole, the Gurney flaps reduced the maximum lift-to-drag ratio (L/D)max for the non-planar wings; however, the flat wing exhibited a small L/D increment with flap addition.
The Key Role of Research in Flight Dynamics, Control, and Simulation for Advancing Aeronautical Sciences
Authors: Abu Salem Karim
Published: September 2024

In the evolving field of research on civil and commercial aviation, the study of flight dynamics, control, and simulation is pivotal for technological progress [...]
Hay Yield, Chemical Composition, and In Vitro Digestibility of Five Varieties of Common Vetch
Authors: Cheng Xiao , Wang Sunze , Zhang Kefan , Jiang Ting , Ye Yang , Lu Yuan , Yu Yajie , Wei Huiqing , Zhang Zijun , Huang Yafeng
Published: September 2024

Diversifying feed with annual legumes could help to reduce reliance on imported sources of alfalfa hay, ensuring a consistent supply of forage throughout year, and potentially decreasing the cost of raising ruminants. This study evaluated the varietal variability in hay yield, chemical composition, carbohydrate and protein fractions, and in vitro digestibility of five common vetch varieties used in this experiment during the full-flowering period in Jianghuai region during the 2022 crop season. Results showed that improved varieties (Lanjian No. 1 and Lanjian No. 2, 6.30 and 6.11 t DM/ha) had significantly higher hay yields than the local variety (333A, Longjian No. 1), with Lanjian No. 3 showing intermediate yields. Variety Lanjian No. 1 had the highest non-protein nitrogen concentration and in vitro digestibility, while Lanjian No. 2 had the highest starch concentration, fraction of intermediately degradable pectin and starch, and fraction of neutral detergent-soluble protein and acid detergent-soluble protein. Pearson correlation showed that hay yield was not significantly correlated with quality parameters. Principal component analysis showed that Lanjian No. 1 and Lanjian No. 2 received higher nutritive value. In summary, Lanjian No. 1 and Lanjian No. 2 had better potential use as high-protein feedstuffs for dairy cattle and sheep in the Jianghuai region based on yield, protein fractions, and in vitro digestibility.
Exploring the Physicochemical and Antioxidant Characteristics of Honey from Eastern Morocco: Insights into Potential Health Benefits and Molecular Docking Analysis
Authors: Abeslami Azzedine , El Farissi Hammadi , El Bachiri Ali , Sindic Mariane , Fauconnier Marie-Laure , Bruneau Etienne , Talhaoui Abdelmonaem
Published: September 2024

This study evaluates the physicochemical properties, phenolic and flavonoid content, antioxidant activity, and molecular docking interactions of honey from eastern Morocco. Analysis confirmed compliance with European Commission standards, with moisture content ranging from 15.39% to 19.74% and pH between 3.79 and 4.94. Carob honey exhibited the highest protein content (0.42%), polyphenol concentration (720.16 mg gallic acid/kg), flavonoid content (90.5 mg catechin/kg), and antioxidant activity (63.5% DPPH inhibition). Strong correlations were observed between phenolic and flavonoid content and antioxidant properties. Molecular docking identified ethyl phenylacetate and thymol as key compounds with significant interactions with cytochrome c peroxidase, suggesting potential therapeutic effects. DFT calculations supported these findings, indicating these compounds may enhance antioxidant activity. The study highlights the exceptional quality and antioxidant capacity of honey from eastern Morocco, reflecting its unique floral sources and potential as a natural source of antioxidants with therapeutic benefits.
Study on the Characteristics of Residual Film–Soil–Root Stubble Complex in Maize Stubble Fields of the Hexi Corridor and Establishment of a Discrete Element Model
Authors: Liu Xiaolong , Shi Ruijie , Zhao Wuyun , Sun Wei , Li Peiwen , Li Hui , Zhang Hua , Wang Jiuxin , Wang Guanping , Dai Fei
Published: September 2024

Plastic film mulching is one of the key technologies for improving agricultural productivity in arid and semi-arid regions. However, residual plastic film can severely disrupt the structure of the topsoil in farmland, leading to a decrease in crop yield. The Hexi Corridor, as the largest seed maize production base in the arid regions of Northwest China, is facing an increasingly prominent issue of residual plastic film recovery. This study designed experiments based on the typical maize planting model in the Hexi Corridor. A discrete element simulation model of the residual film–soil–root stubble complex was established using the Bonding-V2 model and API rapid filling technology. The reliability of the simulation model was verified through shear and puncture tests. The study revealed that the soil type in the Hexi Corridor is heavy sandy soil. The differences between the average maximum shear forces in the simulated and actual shear tests for root stubble–soil complexes at depths of 30 mm, 50 mm, and 100 mm were 4.8%, 6.4%, and 6.5%, respectively. Additionally, the differences in the average maximum vertical loading forces in the simulated and actual puncture tests for root stubble–soil complexes at depths of 50 mm and 100 mm were 6.4% and 12.37%, respectively. The small discrepancies between the simulated and actual values, along with the consistency of particle movement trends with real-world conditions, confirmed the reliability and accuracy of the simulation model. This indicates that the established discrete element flexible model can effectively represent actual field conditions, providing discrete element model parameters and theoretical support for optimizing the design of key components in China’s mechanized root stubble handling and residual film recovery machinery.
Design and Experiment of an Independent Leg-Type Chassis Vehicle Attitude Adjustment System
Authors: Li Chao , Xiang Siliang , Ye Kang , Luo Xiao , Zhu Chenglin , Li Jiarong , Shi Yixin
Published: September 2024

In response to the current low work efficiency of soil ridge-working machinery, as well as its poor stability, passability, and adaptability, this paper designs an independent leg-type working platform that can autonomously adjust its vehicle attitude through LiDAR scanning in a soil ridge-working environment. The platform, in terms of its mechanism and structural design, adopts dual parallelogram mechanisms, dual lead screw mechanisms, and independent column leg mechanisms, with a maximum adjustable ground clearance of 107 mm and a maximum wheelbase adjustment of 150 mm. A gyroscope is mounted at the center of the platform for attitude adjustment, ensuring the accurate data collection of the ultrasonic ranging module. Moreover, the platform adopts an adaptive adjustment method based on vehicle attitude and soil ridge shape parameters, obtaining soil ridge parameters through LiDAR and combining ultrasonic ranging module data with stepper motor pulse signals to obtain the absolute vehicle attitude parameters, using first and second linear regression methods to adjust the vehicle attitude and other working parameters. A prototype was also created, and the test data from the soil obtained through experiments show that, after leveling with the gyroscope leveling algorithm, the average value of the pitch angle is up to 0.6154°, and the average value of the roll angle is up to 0.9989°, with the maximum variance of the pitch angle being 0.0474° and the maximum variance of the tilt angle being 0.1320°. After the ultrasonic ranging module data are filtered by the Kalman filter, the maximum variance is 0.0304, and after applying the final fusion algorithm, the maximum variance is only 0.0085. The LiDAR measurement width value deviates from the actual width value by no more than 1.0 cm, and the LiDAR measurement height value deviates from the actual height value by no more than 1.0 cm. The platform’s actual adjusted width deviates from the actual soil ridge width by no more than 2.0 cm, and the platform’s actual adjusted height deviates from the actual soil ridge height by no more than 1.2 cm. This platform can improve the passability, adaptability, and stability of agricultural machinery in soil ridge work and provide technical references for subsequent related research.
Lightweight Wheat Spike Detection Method Based on Activation and Loss Function Enhancements for YOLOv5s
Authors: Li Jingsong , Dai Feijie , Qian Haiming , Huang Linsheng , Zhao Jinling
Published: September 2024

Wheat spike count is one of the critical indicators for assessing the growth and yield of wheat. However, illumination variations, mutual occlusion, and background interference have greatly affected wheat spike detection. A lightweight detection method was proposed based on the YOLOv5s. Initially, the original YOLOv5s was improved by combing the additional small-scale detection layer and integrating the ECA (Efficient Channel Attention) attention mechanism into all C3 modules (YOLOv5s + 4 + ECAC3). After comparing GhostNet, ShuffleNetV2, and MobileNetV3, the GhostNet architecture was finally selected as the optimal lightweight model framework based on its superior performance in various evaluations. Subsequently, the incorporation of five different activation functions into the network led to the identification of the RReLU (Randomized Leaky ReLU) activation function as the most effective in augmenting the network’s performance. Ultimately, the network’s loss function of CIoU (Complete Intersection over Union) was optimized using the EIoU (Efficient Intersection over Union) loss function. Despite a minor reduction of 2.17% in accuracy for the refined YOLOv5s + 4 + ECAC3 + G + RR + E network when compared to the YOLOv5s + 4 + ECAC3, there was a marginal improvement of 0.77% over the original YOLOv5s. Furthermore, the parameter count was diminished by 32% and 28.2% relative to the YOLOv5s + 4 + ECAC3 and YOLOv5s, respectively. The model size was reduced by 28.0% and 20%, and the Giga Floating-point Operations Per Second (GFLOPs) were lowered by 33.2% and 9.5%, respectively, signifying a substantial improvement in the network’s efficiency without significantly compromising accuracy. This study offers a methodological reference for the rapid and accurate detection of agricultural objects through the enhancement of a deep learning network.
Crop Productivity, Phytochemicals, and Bioactivities of Wild and Grown in Controlled Environment Slender Amaranth (Amaranthus viridis L.)
Authors: Cunha-Chiamolera Tatiana Pagan Loeiro da , Chileh-Chelh Tarik , Urrestarazu Miguel , Ezzaitouni Mohamed , López-Ruiz Rosalía , Gallón-Bedoya Manuela , Rincón-Cervera Miguel Á. , Guil-Guerrero José L.
Published: September 2024

Amaranthus viridis L. is a wild edible plant that occasionally is cultivated as an alternative crop because of its interest as a functional food and its adaptation to high-saline soils. In this work, leaves from A. viridis were compared with their grown in controlled environment (GCE) counterparts in a soilless system at electrical conductivities (EC) and different light exposures for assessing growth parameters, moisture, total phenolic and total flavonoid content, phenolic compound profiles, vitamin C, antioxidant activity, and antiproliferative activity against the HT–29 human colorectal cancer cell line. The highest biomass production was obtained using EC of 2.5 dS m−1 and the AP67 Milk LED lamp. Vitamin C in wild samples ranged from 83.1 to 104.9 mg 100 g−1 fresh weight (fw), and in GCE ones, it ranged from 112.3 to 236.7 mg 100 g−1 fw. Measured by the DPPH and ABTS assays, the antioxidant activity was higher in wild than in GCE plants: the ranges for wild samples were in the 1.8–4.9 and 2.0–3.9 mmol of Trolox Equivalent (TE) 100 g−1 dry weight (dw) ranges, and for GCE ones in the 1.3–1.9 and 1.5–2.2 mmol TE 100 g−1 dw ranges, respectively. As for phenolic compounds, in wild samples, the range was from 14.65 to 22.70 mg 100 g−1 fw, and these amounts were much higher than those found in their GCE counterparts, in which the range was from 2.58 to 5.95 mg 100 g−1 fw. In wild plants three compounds, namely trans-p-coumaric acid, isorhamnetin-3-O-glucoside, and nicotiflorin, accounted for more than half of the total quantified phenolic compounds. The MTT assay revealed concentration- and time-dependent inhibitory effects on HT–29 cells for all checked extracts. Cancer cells were less influenced by extracts from GCE plants, which showed higher GI50 compared to wild plants. This work improves knowledge on the growth parameters, phytochemical profiles, and biological activities of wild and GCE A. viridis.
MiR-206 Suppresses Triacylglycerol Accumulation via Fatty Acid Elongase 6 in Dairy Cow Mammary Epithelial Cells
Authors: Zhao Xin , Liu Yu , Li Yupeng , Zhang Yuxin , Yang Chunlei , Yao Dawei
Published: September 2024

Cow milk possesses high nutritional value due to its rich array of beneficial fatty acids. It is important to understand the mechanisms involved in lipid metabolism in dairy cows. These mechanisms are driven by a complex molecular regulatory network. In addition, there are many regulatory factors involved in the process of fatty acid metabolism, including transcription factors and non-coding RNAs, amongst others. MicroRNAs (miRNAs) can regulate the expression of target genes and modulate various biological processes, including lipid metabolism. Specifically, miR-206 has been reported to impair lipid accumulation in nonruminant hepatocytes. However, the effects and regulatory mechanisms of miR-206 on lipid metabolism in bovine mammary cells remain unclear. In the present study, we investigated the effects of miR-206 on lipid-related genes and TAG accumulation. The direct downstream gene of miR-206 was subsequently determined via a dual-luciferase assay. Finally, the fatty acid content of bovine mammary epithelial cells (BMECs) upon ELOVL6 inhibition was examined. The results revealed that miR-206 overexpression significantly decreased triacylglycerol (TAG) concentration and abundances of the following: acetyl-coenzyme A carboxylase alpha (ACACA); fatty acid synthase (FASN); sterol regulatory element binding transcription factor 1 (SREBF1); diacylglycerol acyltransferase 1 (DGAT1); 1-acylglycerol-3-phosphate O-acyltransferase 6 (AGPAT6); lipin 1 (LPIN1); and fatty acid elongase 6 (ELOVL6). Overexpression of miR-206 was also associated with an increase in patatin-like phospholipase domain-containing 2 (PNPLA2), while inhibition of miR-206 promoted milk fat metabolism in vitro. In addition, we found that ELOVL6 is a direct target gene of miR-206 through mutation of the binding site. Furthermore, ELOVL6 intervention significantly decreased the TAG levels and elongation indexes of C16:0 and C16:1n-7 in BMECs. Finally, ELOVL6 siRNA partially alleviated the increased TAG accumulation caused by miR-206 inhibition. In summary, we found that miR-206 inhibits milk fatty acid synthesis and lipid accumulation by targeting ELOVL6 in BMECs. The results presented in this paper may contribute to the development of strategies for enhancing the quality of cow milk and its beneficial fatty acids, from the perspective of miRNA–mRNA networks.