bluuebunny/crossref_metadata_2025 huggingface dataset:
Indicator species and characterization of the woody and herbaceous layer in an Atlantic Forest ecotone area at the Paraná portion of Serra do Mar
Authors: Miller Daniel Zambiazzi , Higuchi Pedro , Blum Christopher Thomas
Published: April 2023

Abstract The study aimed to evaluate the degree of conservation, analyse the structural and floristic similarity of the woody and herbaceous layers of two ecotone forest communities and evaluate the indicator species of a Mixed Ombrophilous Forest (MOF) and Dense Ombrophilous Forest (DOF). We outlined 30 sampling units of 100 m2 in each area (West and East), where we measured three woody and one herbaceous layers. Each species was classified into ecological groups, phytogeographic distribution and conservation status. We selected other 13 studies performed on similar ecosystems to carry out cluster and indicator species analyses. We registered 213 species, arranged into 63 families. The richest families were Myrtaceae, Lauraceae and Fabaceae. In the woody layers Araucaria angustifolia, Allophylus edulis and Cupania vernalis highlighted in West area, while Casearia sylvestris, Cyathea phalerata and Ilex paraguariensis highlighted in East area. Ctenitis paranaensis predominates in herbaceous layer of both areas. Our cluster analysis has formed two groups (MOF; DOF), including both study areas in MOF group. The study areas are in a maturation process. Serra da Baitaca State Park presents high conservationist importance. We list indicator species of montane MOF and DOF forests in the Paraná State, which can be used for monitoring alterations in vegetation caused by environmental changes.
Effect of bridge design parameters on multi-hazard performance of river-crossing bridges
Authors: Devendiran Dinesh Kumar , Banerjee Swagata
Published: April 2023

River-crossing bridges in seismically active regions are typically susceptible to two natural hazards – earthquakes and floods. For such bridges, design parameters related to piers may play major roles in bridge multi-hazard performance. In this study, the same was explored for key bridge design parameters – the aspect ratio and longitudinal reinforcement ratio of piers and the differential ground elevation between multiple bents. The multi-hazard condition in the southeast of Nepal was considered as the test-bed hazard condition. The regional seismic hazard was represented using a suite of earthquakes generated based on regional seismic design spectra. Due to the flood hazard in the region, expected pier scour of investigated bridges was estimated from 100-year flood discharge (including climate change projection) in the Koshi River, Nepal. Three-dimensional finite-element models of the chosen bridges, with and without scour and with ±10% variations in the stated design parameters, were developed. Fragility and risk curves of the bridges were developed and compared in order to assess the relative influence of the design parameters on bridge performance. It was found that the aspect ratio and longitudinal reinforcement ratio of piers can significantly influence the multi-hazard performance of riverine bridges. The findings also demonstrate how design parameters may be revised to perform risk-targeted multi-hazard design of bridges.
Selling San Narciso: Pierce Inverarity as Insider-Innovator in The Crying of Lot 49
Authors: Johnson Fred
Published: April 2023

This paper puts social networking theory into conversation with ideas from Michel de Certeau and Michel Serres, in order to explore the agency of Pierce Inverarity, whose death sets in motion Thomas Pynchon’s The Crying of Lot 49. Pierce—a 1960s war profiteer, maker of soulless cityscapes, and master manipulator—is justifiably seen as a villain. But he is also the novel’s most effective agent; he manipulates the culture he discovers and cultivates instabilities from which he profits. Lot 49’s protagonist, Oedipa Maas, habitually looks for central managers in control of the culture, but Pierce is not that. Instead, he is an often subtle persuader who designs ephemeral spaces that invite the agency of outsiders. He counts on the creative misuses people may find for his products. He does not have his community’s best interests at heart, but he demonstrates what it means to come alongside a community and foster gradual change. Pynchon—by making his villain an effective community change agent—sharpens his critique of middle-class complacency: Oedipa recoils from the decentralized cultural complexity that Pierce welcomes. Pynchon suggests that so long as Oedipa and her clever, educated cohort think of society as the product of other powerful ruling minds, agents like Pierce will have the advantage, as they diffuse their self-serving innovations through the networks of contemporary life, unchecked.
LIGHT-STIMULATED LOWERING OF GLUCOSE CONCENTRATION IN A DEXTROSE SOLUTION MEDIATED BY MEROCYANINE MOLECULES
Authors: Petriashvili Gia , Chubinidze Ketevan , Tatrishvili Tamara , Kalandia Elene , Petriashvili Ana , Chubinidze Mariam
Published: April 2023

Diabetes mellitus is a chronic metabolic disease characterized by elevated blood glucose levels and has become a global challenge. Currently, the widespread and regular treatment of diabetes mellitus involves the administration of insulin. However, insulin is no longer considered the first choice for type 2 diabetes, and an expanding range of new treatment modalities are emerging as noninsulin-based medications that are promising alternatives to regulate blood glucose levels. In this regard, controlling the glucose level in blood by external stimuli, such as light, offers a new route to governing the blood glucose concentration with the required dose and at the appropriate time. Here, we report on a light-stimulated glucose-lowering method based on spiropyran-merocyanine photoisomerization. We show that upon exposure to violet light (405 nm), the closed isoform of spiropyran molecules inside liquid crystal microspheres transforms into the open merocyanine isoform, which in turn stimulates merocyanine to translocate through the interface of the liquid crystal/dextrose emulsion. Merocyanine readily interacts with glucose molecules and causes a lowering of the emulsion’s total glucose concentration by 20 %.
Breast cancer association with oncogenic papillomaviruses: arguments pro and con
Authors: Volgareva G. M.
Published: April 2023

Possible breast cancer (BC) association with oncogenic human papilloma viruses (HPV) remains subject for discussion. DNA of these viruses was found in numerous BC samples in predominant majority of researches into the problem, that being the main argument in favour of their involvement into genesis of the given tumor. The principal objection to the opinion is that the HPV genomes number per a single cancer cell in HPV-positive BC is several orders of magnitude inferior to the similar indicator for cervical cancer. Urgency of the issue of possible BC association with oncogenic HPVs increases under the development of effective preventive vaccines against HPV infection. To clarify this matter the data might help either confirming or disproving the oncogenic HPV genome activity in DNA HPV-positive BC.
Genes transcriptional activity features in different histological subtypes of tongue squamous cell carcinoma
Authors: Kutilin D. S. , Danilova A. E. , Maksimov A. Yu. , Snezhko A. V. , Engibaryan M. A.
Published: April 2023

Introduction. Over the past decade, tongue cancer has maintained a leading position in the overall structure of the incidence of head and neck malignant tumors. Squamous cell carcinoma of the tongue is an aggressive form and has a clinically unpredictable prognosis. Currently, there are several histological subtypes of this disease. And the search for new prognostic factors that could reflect the actual state of tumor progression and give an objective prognosis of disease development is an important research area in molecular oncology. Such factors may be certain transcriptomic characteristics of tumors, which determine the features of pathogenesis in each specific case.

Aim. To research genes transcriptional activity features in various histological subtypes of tongue squamous cell carcinoma using bioinformatic and molecular approaches.

Materials and methods. The stage of screening bioinformatics analysis was performed using an interactive web server for analyzing data on messenger RNA expression of 9736 tumors and 8587 normal samples from the The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) projects using a standard processing pipeline (GEPIA). The main (validation) stage of the study was performed on 300 patients with locally advanced malignant tumors of the tongue. The quantitative real-time polymerase chain reaction method was used to determine the values of the relative expression of genes identified at the stage of bioinformatic analysis.

Results. Bioinformatic analysis identified 1488 genes that increase expression and 589 genes that decrease expression in tongue squamous cell carcinoma. Of these 2077 genes, 23 genetic loci were selected that most strongly alter expression in tumor tissue relative to normal tissue of the tongue. Of these, when validated by polymerase chain reaction, only 14 changed their transcriptional profile in tumor tissue relative to normal: MMP1, MMP11, CA9, PTHLH, MMP9, LAMC2, MMP3, ANXA1, MT-ND6, CRNN, MAL, TGM3, IL1RN and CLU. The analysis of polymerase chain reaction data revealed significant heterogeneity in a number of biological samples studied. Cluster analysis made it possible to divide the total sample of 300 patients into 3 groups differing in gene expression: cluster 1 (n = 90), cluster 2 (n = 101) and cluster 3 (n = 109), corresponding to the basaloid, acantholytic and usual histological subtypes. Thus, the study made it possible to identify a number of molecular markers of tongue squamous cell carcinoma (MMP1, MMP11, CA9, PTHLH, MMP9, LAMC2, MMP3, ANXA1, MT-ND6, CRNN, MAL, TGM3, IL1RN and CLU), as well as to reveal the transcriptional features of various histological subtypes of this disease.
Study of the suppression of a tumor growth expressing a carcinoembryonic antigen with a new high-tech drug carplasmin (CAR-T therapy) in Balb/c nude mice
Authors: Bozhenko V. K. , Shishkin A. M. , Shkoporov A. N. , Kiseleva Y. Yu. , Kulinich T. M. , Bolshakova O. B. , Kudinova E. A. , Solodkiy V. A.
Published: April 2023

Introduction. Adoptive immunotherapy based on chimeric antigen receptors (CAR) is considered as a promising direction in the treatment of solid malignant tumors. To produce genetically modified human T-lymphocytes, lenti/retroviral transduction is currently most often used. However, safety concerns associated with the viral vector production and possible unwanted genome modification limit the clinical utility of CAR-T cells. Therefore, non-viral transfection methods, in particular electroporation, using of DNA or RNA vectors, are being actively studied as a method for producing CAR-T lymphocytes.

Aim. To evaluate in vivo antitumor activity of the new high-tech drug carplasmin, intended for CAR-T therapy of tumors expressing carcinoembryonic antigen (CEA). Materials and methods. Carplasmin was obtained by electroporation of activated human lymphocytes with plasmid DNA carrying the third generation CAR gene specific to CEA. The study was performed on a human colorectal cancer xenograft model obtained by intraperitoneal injection of CEA-positive HCT116 cell line to athymic Balb/c nude mice. Carplasmin treatment was carried out once a week, starting from the third day after HCT116 cell inoculation. Mice in the two control groups were treated with either electroporated lymphocytes without plasmid addition (pulse-lymphocytes) or RPMI-1640 culture medium (group without treatment).

Results. In vivo, carplasmin demonstrated a pronounced antitumor effect. Seven weekly injections of the drug to inoculated mice led to a prominent effect of antitumor therapy: 80 % of the animals in the experimental group survived (with 40 % of the mice had a complete remission without signs of a detectable tumor), compared to 100 % death in the control group (without treatment).

Conclusion. The results of preclinical efficacy studies demonstrate that carplasmin is a promising drug for the treatment of CEA-positive intraperitoneal tumors.
Hereditary diffuse gastric cancer associated with a novel germline variant c.1596G>A in the CDH1 gene
Authors: Danishevich A. M. , Lisitsa T. S. , Nikolaev S. E. , Abramov I. S. , Filippova M. G. , Pospekhova N. I. , Stroganova A. M. , Nikulin M. P. , Kalinin A. E. , Stilidi I. S. , Lyubchenko L. N.
Published: April 2023

Gastric cancer is one of the most common malignancies worldwide. Approximately 10 % of patients with gastric cancer are characterized by accumulation of gastric cancer cases in their family. The hereditary forms of gastric cancer account for 1–3 % of all gastric cancer cases. Hereditary diffuse GC syndrome is caused by germline mutations in CDH1 gene and determines a high risk of developing diffuse GC and lobular breast cancer. In this article, we present a clinical case of a 41-year-old patient with diffuse gastric cancer, who was found to be a carrier of novel germline mutation in the CDH1 gene. Next-generation sequencing (NGS) has facilitated an identification of CDH1 c.1596G>A genetic variant, thus enabling an accurate clinical diagnosis hereditary diffuse gastric cancer.
The effective use of neoepitope-based vaccines in personalized cancer immunotherapy
Authors: Ugovsek Ryan , Lee Cecilia
Published: April 2023

In an era where modern medicine has increased the duration and quality of life, cancer remains one of the world’s leading causes of death [1]. As cancer is characterized by random and somatic mutations within each tumour’s specific genome, personalized immunotherapies have become increasingly popular as potential courses of treatment [2-6]. Notably, therapeutic neoepitope-based vaccines have been shown to elicit potent, T-cell-mediated antitumour activity in numerous clinical and preclinical models. As an immunotherapy, neoepitope vaccination harnesses the immune system’s specificity to target tumour-specific markers present on cancer cells [2]. Thus, neoepitope vaccines represent a new frontier in personalized cancer treatment [2]. Although challenges remain in the development and administration of neoepitope vaccines, the technology shows incredible promise and merits further research. The following viewpoint will explore the efficacy of this emerging immunotherapy, support the case for its integration into modern healthcare, and identify areas that require further exploration.
Design of Bio-Inspired Optimized Integer And Fractional Pid Controller
Authors: Verma Tushar . , Saeed Syed Hasan
Published: April 2023

The PID controllers are being widely used in almost every real-time engineering problem in accordance with the increasing demand for aquick and consistent response of the system. To justify the performance of PID controllers, a mathematical model of an electric motor is considered in this paper. The complete system is simulated on MATLAB/SIMULINK with an integer and fractional-order PID controller and analyzed in terms of control characteristics. A comparative study of the various closed-loop response of the system is also carried out to compare the performance of an integer and fractional-order PID controller. The controllers used in the system are modern optimized, i.e., the particle swarm optimization technique is used to acquire a more optimized system response. The simple concept of application of integer and fractional-order PID controllers is proposed in this research article. A similar approach can be applied to various real-time problems to obtain optimized results. However, other modern optimization techniques are also available and emerging regularly that can produce a stable and optimized response to satisfy the demand for system stability.
Analytical Study of Effects of Lockdown on Air Pollution And Comparisonof Air Quality of Pune, Maharashtra, India Before And During The Lockdown
Authors: Patil Dipali S. , Sawai Deepali S.
Published: April 2023

Significant reduction in air pollution has occurred during the period of lockdown due to COVID-19 pandemic situation. It has given a wonderful opportunity to compare the air pollution as Industries and the maximum traffic of the city had been stopped during the lockdown, which otherwise could not be possible, to stop all the traffic and observe the impact. The study aims to compare the air pollution levels before and during the lockdown period in different areas of Pune city. The daily data of Air Quality Index, Sulphur di oxide and Oxides of Nitrogen is collected, compared, and analyzed. Analysis shows the fall in AQI in large extent which can be directly corelated with the traffic reduction in the city. The other factors like winter inversion, seasonal and festival effects are also considered for analysis. The data is also compared with previous year data for fair conclusions. The result shows the influence of anthropogenic sources of air pollution on AQI.
Failure Analysis – An Overview with Case Study
Authors: Sivaraman Krishnan , Singh Abhishek
Published: April 2023

Failure analysis is an important tool to determine the physical root causes of problems. The process is critical, based upon many different technical disciplines and uses a variety of observation, inspection, and laboratory techniques. It relies on collecting failed components for subsequent examination of the cause or causes of failure using a wide array of methods, especially microscopy and spectroscopy [1]. One of the important parameter in performing a failure analysis is properly observing each and every factor related to failed component and provide unbiased conclusion and corrective action. The objective of failure analysis is to identify whether component or product has failed in service or during manufacturing or during production processing. In any case, one must determine the cause of failure to prevent future occurrence, and/or to improve the performance of the device, component or structure.

 This paper briefly introduces the basics of failure analysis, various modes of failure and the role of failure analysis as a general engineering tool for enhancing product quality and failure prevention. In addition, this paper also covers a typical case study to explain the process methodology in detail.
Disk Comparison to Achieve a Load-balanced Solution in Azure Cloud Systems
Authors: Kolte S S , Pradhan M A
Published: April 2023

The main goal of this paper is to know and evaluate how to avail various cloud computing services provided to get the best performance cost-effectively and can be used in load balancing. Load balance plays a crucial role in the information acquiring system’s performance which helps to get maximum results in minimum response time in the education field and in any business environment. Mainly in the situation of cloud storage, the load balance is well done, which brings to the full consumption of computing resources and reduces the response time of distributed operations. Load balancing can be done only when all the storage nodes are in data sync. This paper mainly focuses on cloud Storage types available in Azure VM and their performances to achieve data replication and load balancing.
Dynamic Analysis of Cantilever Retaining Wall
Authors: Patil Prajakta , Waghmare M V
Published: April 2023

Retaining walls are relatively stiff walls used for supporting soil laterally. Study of seismic behavior of retaining wall is important for safe design and to know the behaviour of how the response of soil influences the motion of the structure. This paper presents static and dynamic analysis of cantilever retaining wall by 3D finite element analysis using ANSYS software. Aim of this study is to investigate seismic behaviour of wall. For that purpose, soil modeling is done by direct method of analysis carried out by bonding of wall and soil together. Study contains three-parts, modal analysis is carried out after static analysis, mode shapes and natural frequencies of the wall is calculated and then nonlinear time history analysis is done by using three different earthquake ground motions. The influences of parameter are discussed such as dynamic characteristics of wall and soil, shear stresses, equivalent stresses. From this analysis it is observed that maximum displacement occurs at top of the wall and wall does not fail under given loading condition. The significant effect on seismic behaviour of retaining wall has been found in the soil. Also, the Equivalent (Von Mises) stress distribution for retaining wall supporting clayey soil, the lowest Von Mises stress values are detected near the ground level and increases at bottommost of retaining wall and higher stress detected amongst the base slab and the stem of the retaining wall in the soil cover zone.
Grading Method of Ensemble and Genetic Algorithm for Intrusion Detection System
Authors: Gaikwad D P , Chaitanya S V
Published: April 2023

Intrusion Detection System is very important tool for network security. However, Intrusion Detection System suffers from the problem of handling large volume of data and produces high false positive rate. In this paper, a novel Grading method of ensemble has proposed to overcome limitation of intrusion detection system. Partial decision tree (PART), RIpple DOwn Rule (RIDOR) learner and J48 decision tree have used as base classifiers of Grading classifier. Optimzed Genetic Search algorithm have used for selection of features.These three base classifiers have graded using RandomForest decision tree as a Meta classifier. Experimental results show that the proposed Grading method of classification offers accuracies of 81.3742%, 99.9159% and 99.8023% on testing, training datasets and cross validation respectively. It is found that the proposed graded classifier outperform its base classifiers and existing hybrid intrusion detection system in term of accuracy, false positive rate and model building time.
Query Optimization in Object Oriented Database Using Cursor with Special Reference to Parallel Processing
Authors: Banubakode Abhijit , Gadhia Mohammed
Published: April 2023

Intrusion Detection System is very important tool for network security. However, Intrusion Detection System suffers from the problem of handling large volume of data and produces high false positive rate. In this paper, a novel Grading method of ensemble has proposed to overcome limitation of intrusion detection system. Partial decision tree (PART), RIpple DOwn Rule (RIDOR) learner and J48 decision tree have used as base classifiers of Grading classifier. Optimzed Genetic Search algorithm have used for selection of features.These three base classifiers have graded using RandomForest decision tree as a Meta classifier. Experimental results show that the proposed Grading method of classification offers accuracies of 81.3742%, 99.9159% and 99.8023% on testing, training datasets and cross validation respectively. It is found that the proposed graded classifier outperform its base classifiers and existing hybrid intrusion detection system in term of accuracy, false positive rate and model building time.
Digital Technology's Application: Using Data Science Access, a Structured Exploration of the Composition for Senior Adults
Authors: Banubakode Abhijit , Patil Harshali , Chougule Sahil
Published: April 2023

In the last few years, social media usage has swept the globe, and the number of users has exploded. From arranging neighbourhood meetings to reconnecting with old friends, social media has helped to make the world a smaller place and brought generations together on a common platform. Social media has changed the way we engage with the world around us, and social media sites are now considered as valuable companions for senior citizens (those aged 60 years and above).It’s crucial to understand how this age group uses social media, as well as the potential benefits and drawbacks of doing so. This chapter provides a structured overview of social media and its use to senior citizens. It also focuses on the senior’s interests and priorities for using specific social media networks. The use of social media by seniors has increased significantly over the years; formerly, it was primarily used by the younger generation. Those who live alone, in particular, are increasingly adopting social media to better connect with the world around them. The pandemic lockdown time has also put pressure on many seniors to learn how to utilise social media platforms to stay in touch with family and friends.
Investigation on Seismic Performance of Outrigger Structure For High Rise Building
Authors: Patil Pratiksha , Satarkar P R
Published: April 2023

As of today's growing population, tall buildings are now being built, with various sorts of high-rise buildings
in terms of lateral resisting systems. Outriggers are one of the most effective lateral load resisting techniques
for increasing the stiffness and seismic capabilities of a building. Shake table tests are effective ways of
determining a building's seismic capacity in seismic engineering. Due to the limited size and capacity of
existing shake tables, scale structural models will be required. However, to know the real effect of a building
and because of the limited capacity of shake table, we can use software to analyze building's seismic
performance. In this paper, an investigation of the seismic performance of past experimental work has been
performed in the software Etab, and to validate the result same method has been applied. A software tool
was used to do modal analysis on the prototype structure, and the experimental data was compared with
the software results to acquire a better understanding of the building's seismic performance. In past
experimental study, free vibration test was carried out to know the time period of the structure. In order to
observe the same result, modal analysis is performed in software to find out modal period and the damping
ratio was calculated manually. After comparing the software result and experimental values of time period
and damping, it was clear that the software application and the experimental findings were in good
concordance.
External Portable Cooling System for Mobile Phones
Authors: Chaitanya S V , Gaikwad D P , Ali Hyder , Gurav Sudhanshu , Thakur Harsh , Hatkhambkar Advait , Horne Rushikesh
Published: April 2023

Basically, a cooler word depicts the meaning of cool or relief from heat. Same as above a phone cooler cool down the phone or gives relief from heat which is radiated due to continuous use of phone. The working principle of the cooler is so easy to understand. Now- a-days power dissipation levels in mobile phones are continue to increase due to gaming, higher power apps and increased functionality associated with internet. With this power dissipation level, products such as mobile phones will require active cooling to ensure that the comfort and reliability perspectives. The current cooling methodologies of natural convection and radiation limit the power dissipation within a mobile phone to between 1-2 w depending on size. In this paper, the external portable mobile phone cooling system has proposed. This system does not need any changes in designing of mobile phone. It can be used for any types of mobile phone. The proposed cooling system is portable and reliable in cooling phones. The result of this project shows up to phone heating can be controlled in any condition without any external higher power source.It has very less limitations. If the model is connected to phone to provide input power to it the fan and cool it, it will result in drainage of battery of phone. It will not so comfortable to use it for long time less than two hours.
History and Assessment of the War Environment on the Subsequent Health of the Vietnam Veteran
Authors: Young Alvin , Alexander Lynda
Published: April 2023

In January 1962, the first Allied combat, combat advisory, and support forces arrived in South Vietnam. By the end of the War, almost 3 million allied personnel had been engaged in this violent Conflict. Six nations provided the Allied Military Forces to support the Republic of South Vietnam from 1965 through March of 1973. The tropical environment posed many challenges to the Allied Military Forces in waging a war against an elusive enemy who had a history of fighting in such an environment. Most Allied combat units spent weeks in the brush enduring the inhospitable environment that included an invisible but deadly enemy. For those soldiers living in outposts or isolated bases or airfields, the constant enemy shelling deprived them of sleep, leaving them exhausted, disoriented, and too often contentious and increasingly depressed. Beyond the possibilities of injury and death during combat, military personnel were exposed to diverse agents and environments that may have affected their health, and thus caused injury and disease while in service or after discharge. Indeed, insect-transmitted diseases and other health related issues accounted for more casualties then did enemy bullets and bombs. Many of those exposures reflected the diverse tasks and functions of military personnel serving in unfamiliar environments associated with combat operations. Fifty health studies of Vietnam veterans by four of the Allied Nations confirmed that with two exceptions, no Vietnam veterans were ever exposed to Agent Orange. What the health studies did confirm was the impact of the “Vietnam Experience” on the long-term health of the men and women who served in the Vietnam War.
ON EXPONENTIAL STABILITY OF A CLASS OF DELAY DIFFERENTIAL EQUATIONS IN NEOCLASSICAL GROWTH MODELS
Authors: Hoang Tuan Nghia
Published: April 2023

In this paper, the problem of global exponential stability of delay differential equations in a neoclassical growth model is investigated by comparison techniques via differential inequalities.
COHEN-MACAULAYNESS OF SOME EDGE-WEIGHTED GRAPHS
Authors: Ly Thi Kieu Diem , Nguyen Phung Nguyen
Published: April 2023

In this paper, we will study the characterization of Cohen-Macaulayness of some edge-weighted graphs. For cycle and tree edge-weighted graph, we will reprove the characterization of Cohen-Macaulayness of an edge-weighted cycle and an edge-weighted tree due to C.Paulsen and Wagstaff (2013) [1]. Our proof used a criterion of Hochster for Cohen-Macaulayness of a monomial ideal [2].
SYNTHESIS OF SOME BENZOTHIAZOLE ANILINE DERIVATIVES AND THEIR BIOLOGICAL ACTIVITIES
Authors: Duong Quoc Hoan , Nguyen Duc Du , Truong Minh Luong , Nguyen Thi Thach Thao , Nguyen Thi Thu Hien
Published: April 2023

Three benzothiazole aniline derivatives 2a, 2b, and 2c were synthesized successfully by the reduction reaction of the respective nitro compound in neutral condition with Na2S2O4 in moderate yield. Structures of these derivatives were elucidated by IR, NMR, and MS analysis that referred to a strong agreement between spectral data and structures. Three compounds 2a, 2b, and 2c showed weak antioxidant, antibacterial and antifungal activities.
SODIUM SULFIDE-PROMOTED REACTION OF 2-AMINOBENZAMIDE AND BENZYL ALCOHOLS WITH ELEMENTAL SULFUR: A NOVEL APPROACH WITH 2-ARYL-QUINAZOLIN-4(3H)
Authors: Nguyen Hien , Nguyen Trung Hieu , Nguyen Thi Ngoc Mai , Pham Thi Thu May , Nguyen Thi Thu Hien , Duong Quoc Hoan
Published: April 2023

Six derivatives containing benzoxazole were synthesized from phydroxybenzaldehyde via four step-route in high yields. The benzoxazole cyclization step was promoted with microwave irradiation for 10 to 30 min. Free oaminophenol derivative A3 reacted with aldehydes to form benzoxazole A4a-f, but A3.HCl couldn’t due to the presence of iron (II). Their structures were elucidated with spectroscopic methods: IR, 1D, 2D NMR, and MS.
DETERMINATION OF SOME NUTRITIONAL COMPONENTS AND SENSORY CRITERIA OF IGNAME YAM IN BAC GIANG PROVINCE (Dioscorea esculenta)
Authors: Nguyen Van Loi , Le Anh Tuan , Do Thi Hanh
Published: April 2023

Igname yams are agricultural products with high economic and nutritional value. Igname yam plants are grown a lot in our country, especially in Bac Giang province. The aim of this study was to the determination of nutritional components and sensory of igname yam in Bac Giang province. Research results have identified water content in igname yam is 69.3 ± 0.2%, total lipid content is 4.2 ± 0.1%, total glucide content is 20.5 ± 0.1%, total protein content was 2.6 ± 0.1%, vitamin B1 was 28.5 ± 0.1mg% and vitamin B2 was 12.3 ± 0.1mg%. Besides, the content of minerals, such as Ca, Mg, Mn, P, K, Na, Zn, Cu, S, and Fe, fluctuates in the range of 1.4 to 34mg%. By the HPLC method, 17 amino acids have been identified in igname yam. Among those, there were 9 non-substituting amino acids, including histidine, arginine, threonine, valine, methionine, lysine, isoleucine, leucine, and phenylalanine. The igname yam meat has an ivory white color, a characteristic aroma, a fatty taste, a spongy and friable structure. These are important scientific bases for selecting igname yam for processing food products.
OPTIMIZING GENOTYPING PROCEDURE AND DETERMINING FREQUENCY OF SINGLE NUCLEOTIDE POLYMORPHISM RS7799039 BELONGING TO LEP GENE IN FOUR-YEAR-OLD BOYS IN HANOI
Authors: Nguyen Thi Trung Thu , Pham Bui Quang Minh , Le Thi Tuyet
Published: April 2023

The LEP (leptin) gene plays an important role in the regulation of food intake and energy metabolism. The single nucleotide polymorphism (SNP) rs7799039 located in the promoter of the LEP gene may affect the risk of obesity and other diseases such as diabetes, cardiovascular disease, cancer, etc. due to altering the gene expression. The objective of this study is to find out the optimum procedure for genotyping SNP rs7799039 by using the polymerase chain reactionrestriction fragment length polymorphism (PCR-RFLP) method and determine the allele and genotype frequencies of this SNP in 61 four-year-old boys with normal nutritional status in Hanoi. The sequence of primers has been designed as follows: forward primer 5'-tttcctgtaattttcccatgag-3' and reverse primer 5'-aaagcaaagacaggcataaaa-3'. The thermal cycle for the PCR reaction includes initiation at 94 °C (3 minutes), 34 cycles of denaturation at 94 °C (30 seconds), annealing at 56 °C (30 seconds), extension at 72 °C (30 seconds), final extension at 72 °C (8 minutes), and then keep the products chilling at 4 °C. HhaI restriction enzyme was used to distinguish A and G alleles of rs7799039. PCR products are incubated with 0.5 µl HhaI restriction enzyme for 15 minutes at 37°C and then the products of restriction enzyme digestion are separated by gel electrophoresis. Genotype frequencies of our studied population are 62.3% AA, 31.1% AG, and 6.6% GG (P HWE = 0.452).
USING SENTINEL IMAGES FOR THE ESTIMATION OF RICE BIOMASS IN QUOC OAI DISTRICT (HANOI)
Authors: Dang Vu Khac , Doan Hoai Trang
Published: April 2023

During the rice production process, the rice straw - one of the residual products becomes an environmental pollutant due to the open burning giving rise to greenhouse gases emission. That’s why the identification of gas emissions needs to estimate the amount of rice biomass. Remote sensing data has been exploited to determine the area of rice cultivation and to estimate the dry rice biomass in Quoc Oai district, Hanoi city. On the one hand, the Sentinel-2 image was used to classify the land cover categories, thereby identifying the spatial distribution of the rice to delimit the extent of rice biomass, which was obtained from regression analysis. On the other hand, the Sentinel-1 radar image was used to calculate the rice biomass during the summer season when Sentinel-2 images have constraints due to clouds, fog, and mist. The validation of image classification has provided an overall accuracy of 86.31% with a Kappa index of 0.81. Meanwhile, the regression analysis shows a high correlation between the backscattering values of VV and VH in the radar image and the dry rice biomass measured on the ground (R = 0.923 and R2 = 0.852), with a relatively low average error (RMSE = 6.58 kg\100 m2). By linear regression method, the study has found the total dry rice biomass of 28728.5 tons, which was revealed after the Summer-Autumn rice crop 2021 for the whole Quoc Oai district. The results from this study have proved the effectiveness of the method and they have contributed to supporting managers in proposing the appropriate policies to monitor and protect the environment in the future.
ASSESSING THE RELATIONSHIP BETWEEN URBAN GREEN SPACE AND URBAN HEAT ISLAND IN HANOI CITY
Authors: Duong Thi Loi
Published: April 2023

Uncontrolled urbanization with the encroachment of constructions has caused negative impacts on the environment, promoting a significant increase in temperature in the cities. The urban heat island (UHI) effect is making the climate in cities more extreme, increasing energy consumption and seriously affecting people's health. Green space development is considered a strategic solution to limit the negative impacts of the urban heat island effect. The main purpose of this study is to assess the relationship between urban green space and urban heat island effect in Hanoi city. The normalized vegetation difference index (NDVI) and land surface temperature (LST) extracted from the 2015 and 2020 Landsat satellite data of Hanoi city were used for analysis, comparison, and analysis to determine the role of green space in keeping the temperature down in summer temperature. Research results showed that green space plays an important role in cooling in the summer period. At the same time, the surface temperature in the non-vegetated areas is always higher than that in the vegetated areas at high levels of 2 to 3°C. The research results provide a significant source of reference material that makes an important contribution to an effective and sustainable urban planning strategy.
DOCUMENTARY OVERVIEW SYSTEM ON SOCIAL WORK IN THE PREVENTION OF CHILD LABOUR IN VIETNAM
Authors: Hoang Thi Hai Yen
Published: April 2023

Child labor is still a persistent problem in the world today, including Vietnam. The percentage of children in early labor according to statistics tends to increase after the impact of the Covid 19 pandemic worldwide. This situation causes many serious consequences for the children themselves, their families, and the social community. Faced with that situation, it is necessary to further improve the prevention and reduction of child labor. The social work profession has affirmed its advantages and effectiveness in preventing, supporting and intervening in difficult problems in schools. Social work activities in the prevention of child labor at schools will help retain students to stay in school and minimize the consequences of child labor, especially those related to the children themselves. Although this is a new approach, it will confirm certain effectiveness in the prevent ion and reduction of child labor from the perspective of social work. That is also the main issue discussed in the content of this article. The article is the result of collecting, analyzing, synthesizing and systematizing 26 prestigious and reliable documents, including reports on child labor in the world and in Vietnam, textbooks, published articles in international journals and conferences with peer review, publication, dissertations and dissertations related to the issue of social work in the prevention of child labor in Vietnam. Therefore, the overview of theoretical studies will help visualize the general picture of the approach, content and implementation of social work activities in the prevention of child labor, thereby creating an important premise for the implementation and evaluation of the effectiveness of these activities in practice.
Some of the Training solution Preschool teachers Accessory Emotional - social capacity
Authors: Le Thi Luan
Published: April 2023

Preschool teachers are an important factor in determining the quality of preschool education. Currently, the new Early Childhood Education Program (ECE) is being renewed in the direction of a competency approach, especially with SEL (emotional-social) as the focus. Social contact is a necessary requirement to improve the professional capacity of preschool students at preschool teacher training institutions. In this article, we focus on introducing core social-emotional (SEL) competencies, thereby recommending some solutions to training preschool teachers towards a competency-based approach (SEL) in schools. Vietnam's colleges and universities contribute to further improving the quality of training to meet the current requirements of reforming preschool education in the direction of approaching learners' capabilities.
Design and use situations to educate gratitude for 5-6 years old
Authors: Le Thi Nhung , Bui Thi Lam
Published: April 2023

Gratitude is a positive emotion and important role in the process of forming human personality from preschool age. Educating children about gratitude for the things, phenomena, and people around them is very necessary, especially for 5-6 years old because gratitude has clearly shown at this age. Building and using situations is one of the ways to teach gratitude to children. Based on the results of theoretical research, the article focuses on clarifying the process of designing and using gratitude education situations for 5-6 years old with illustrative examples. Accordingly, preschool teachers can design more different situations and use them to make gratitude education for 5- 6 years old more effective.
Proposing way to use storybooks to regulate emotions for preschool5-6 years old
Authors: Nguyen Thi Thanh Huong , Tran Thi Lan Huong
Published: April 2023

Considered as an effective means of not only developing language, providing knowledge, and enhancing imagination for children, story books are also a tool to help children recognize and regulate emotions. The article proposes four ways to use comics to regulate emotions for preschoolers 5-6 years old, including 1. Choosing story books with emotional regulation value, 2. Organizing role-playing games to be transferred can be from the content of comics to regulate emotions. 3. Read story books to regulate emotions after a situation where children lose control of their emotions. 4. Collaborate with parents in using comic books to help children regulate their emotions.
Social awareness education for childlen with asd 5-6 years old in steam oriented preschool
Authors: Nguyen Thi Nhu Quynh , Nguyen Cong Khanh
Published: April 2023

Education of social cognition through experiential activities with an interdisciplinary approach, which combine with practical lessons for children with autism spectrum disorder (ASD) 5- 6 years old integrates into issues related to science, technology, engineering, art and math in specific contexts, creating conditions for children with ASD 5-6 years old to accurately understand other people's emotions, empathize, care, create interaction, behave positively with people around, bring value to the community. This study focuses on presenting 4 main components of a theoretical model of social cognitive education for children with autism spectrum disorders aged 5-6 years old in STEAM-oriented preschools with a combination of construction from social emotional learning theory, theory of STEAM education and theory of children with ASD according to ICD 10, ICD 11, including: Social emotions; Sharing cooperation; Social adjustment; Communicate behavior.
Designing of STEAM activities to increase the participation of children with disabilities in inclusive kindergarten
Authors: Tran Thi Minh Thanh , Nguyen Minh Phuong , Hoang Thi Le Quyen , Dao Thi Phuong Lien
Published: April 2023

STEAM is defined as Science and Technology, interpreted through Engineering and the Arts, all based in a language of Mathematics. Over the world, STEAM education has been confirmed as an appropriate approach for all children, including children with disabilities. In Vietnam, STEAM education has been paid attention in recent years and implimented as pilot models in a limited number of main international, private and public schools. Based on the analysis of previous researches about STEAM, characteristics of students with disabilties and STEAM education for children with disabilities, this article aims to provide some suggestions and illustrate the design of STEAM activities to increase the participation of children with disabilities in inclusive kindergarten.
Applying Finger Math method in activities to get acquainted with some elementary concepts of math according to the approach of STEAM education in inclusive preschool for children with intellectual disabilities
Authors: Vuong Thuy Duong , Nguyen Thi Cam Huong
Published: April 2023

STEAM education is now very focused in schools, including inclusive preschools for children with intellectual disabilities. Mathematics is one of the core contents of STEAM education. The use of Finger Math, one mental math method in activities to get acquainted with some elementary concepts of math has many advantages in realizing the goals of forming symbols for preschool children and children with intellectual disabilities in inclusive settings. When organizing these activities, teachers can apply the Finger Math method according to the STEAM approach by enhancing the exploitation of image features symbols, practice associated with real situations, experiential practice, enhance children's initiative and cooperation.
Adjustment of teaching plans in Vietnamese subject for students with hearing and speech disabilities in General Education Program 2018
Authors: Nguyen Minh Phuong , Nguyen Ha My
Published: April 2023

For students with hearing and speech disabilities, hearing loss affects the student’s development in all areas such as cognition, behavior, language, etc., especially in the field of language and communication. Therefore, students with hearing and speech disabilities face difficulties in most areas of learning, especially in learning Vietnamese subject. This article analyzed the difficulties in learning Vietnamese subject of students with hearing and speech disabilities. The authors also proposed some adjustment to the Vietnamese teaching plans according to the General Education Program 2018 in order to appropriate the abilities and needs of the students with hearing and speech disabilities, help them develop their full potential, and achieve the basic requirements of the subject.
Current situation to social awareness education via experience activity with STEAM for integrating and 5-6-year-old children at the nursery
Authors: Nguyen Thi Nhu Quynh , Nguyen Cong Khanh , Hoang Thi Nho
Published: April 2023

Experiential activities with STEAM are an interdisciplinary approach to learning. In the process of social cognitive education (SCE) for children with autism spectrum disorder (ASD) 5-6 years old, educators will combine simple topics and concepts related to Science, Technology, Engineering, Art and Mathematics in specific contexts and associated with children's daily life. This study aims to present the results of a survey of 480 preschool teachers and administrators at inclusive preschools in Ho Chi Minh City on the perception of SCE goals for children with ASD 5-6 years old through the STEAM experience. The survey results show that the majority of preschool teachers are properly aware of the goal of SCE through STEAM experiences for children with ASD 5-6 years old. However, there are still a significant number of preschool teachers who have not shown the correct and appropriate awareness of this SCE. The actual results also indicate some necessary requirements for SCE through STEAM experiences for children with ASD 5-6 years old. This result contributes to providing useful information in building a measure of SCE through STEAM experience for children with ASD 5- 6 years old in inclusive preschools in Vietnam.