bluuebunny/crossref_metadata_2025 huggingface dataset:
Registro do farmacêutico hospitalar no prontuário do paciente: Ensino e prática no Brasil
Authors: de Lima Émilin Dreher , Blatt Carine Raquel , Caregnato Rita Catalina Aquino
Published: March 2023

Registar de forma clara e ordenada no prontuário do paciente possibilita a comunicação entre a equipe multiprofissional e facilita a continuidade do cuidado. O objetivo deste estudo foi conhecer a opinião e a prática dos farmacêuticos hospitalares e professores de graduação em Farmácia sobre a atuação e a formação relacionadas ao registro/documentação no prontuário do paciente no Brasil. A coleta de dados ocorreu por meio de dois questionários eletrônicos, direcionados a farmacêuticos atuantes em hospitais brasileiros e a professores dos cursos de Farmácia. Participaram do estudo 47 professores e 248 farmacêuticos. Em relação aos professores evidenciou-se que: 66% abordam o tema registro em prontuário em aula com uma carga horária média de 11,55 ±16,14 horas; 42,6% disponibilizam aos alunos acesso ao prontuário; 100% consideram o tema importante. Os professores que informaram maior carga horária de aula destinada ao tema consideram o farmacêutico egresso preparado para documentar em prontuário (p= <0,05). Entre os farmacêuticos participantes: 77,33% já documentaram em prontuário; 58,06% receberam instrução formal sobre o tema; 89,92% afirmaram que os farmacêuticos devem documentar o cuidado ao paciente em prontuário. Formação acadêmica, experiência em Farmácia Clínica, conhecimento sobre legislação e metodologia de registro foram apontados como fatores determinantes para o registro em prontuário (p < 0,05). A documentação do farmacêutico no prontuário do paciente foi considerada importante pelos farmacêuticos docentes e atuantes na área hospitalar, portanto a pesquisa e a educação permanente sobre esse tema devem ser estimuladas em todos os níveis de formação profissional.
Dynamic characteristics analysis of a novel vibrating screen based on electromechanical coupling simulation
Authors: Wang Zhenqian , Wu Jida , Kou Zhaojun , Zhang Yuanming , Liu Chusheng
Published: March 2023

The vibrating screen with statically indeterminate mesh beam structure (VSSIMBS) is a novel type of large vibrating screen, which is widely used in coal preparation plants due to its high strength and processing capacity. In this study, the VSSIMBS motion differential equations were obtained via on Lagrange equation, and the dynamic vibration system model was established. The eccentric block force conditions during the operation were analyzed, and the stable vibrating screen operational conditions were obtained. The electromechanical coupling simulation model of VSSIMBS was built in Simulink, allowing frequency control and vibration synchronization experiments. Experimental frequency control results have shown that when the output characteristics of both motors are either the same or similar, synchronous movement can be achieved. Regarding vibration synchronization, experiment results have shown that when two motors are in synchronous motion, and the power supply of one motor is cut off, they still can operate synchronously. Thus, the experimental results obtained in this study provide a theoretical reference for improving the motion stability of large vibrating screens.
Detection and Localization of Premature Flow Transitions on Rotor Blades
Authors: Parrey Ann-Marie , Sorg Michael , Fischer Andreas
Published: March 2023

Defects or contaminations on a wind turbine’s rotor blade can lead to wedge-shaped regions with turbulent flow, which can decrease the energy output of the wind turbine. An automated algorithm is proposed, which detects turbulence wedges in thermograms even for low contrast-to-noise ratios by using prior knowledge about the wedge shape. The algorithm is verified with simulated thermograms and validated with a measured thermogram of a rotor blade of an in-service wind turbine.Even at a contrast-to-noise ratio of 2, all turbulence wedges are detected and their dimensions are quantified. Additionally,the results are mapped to the blade’s geometry to realize 3D thermography
Heat transfer of impinging sweeping jets
Authors: D’Angelo C , Paolillo G , SGreco C , Astarita T , Cardone G
Published: March 2023

The convective heat transfer performances of sweeping jets impinging on a heated thin foil are experimentally investigated.The investigations are performed by employing Infrared Thermography technique coupled with the Heated Thin Foil heat flux sensor.In particular, two sweeping jet devices, characterized by different mixing region lengths, are employed and their heat transfer performances are evaluated for nozzle-to-plate distances ranging between 0.5 and 10.Time-averaged and phase-averaged analyses have been performed in order to characterize the heat transfer behaviour of these sweeping jetsand the influence of the mixing region length
Examples of singular value decomposition contribution in helping cultural heritage works of art conservation using stimulated infrared thermography
Authors: Mouhoubi K , Dieng K , Fomena C , Feddini H , Salami A , Vallet J M , Bodnar JL
Published: March 2023

As part of aid for the conservation of cultural heritage works of art, Infrared thermography is already widely used. However, the photothermal signal obtained can be dependent on the different colors of the pictorial layer of the artwork studied and on the inhomogeneity of energy deposition. In this work, we show experimentally, during the study of a marquetry chessboard and a "Vallauris pottery", that the combination of singular value decomposition with stimulated infrared thermography allows a significant reduction of these radiative effects. Consequently, it allows for better detection of the defects present in the works of art studied
Covid-19, wearing N-95 masks in Clinical Environments: Thermographic Detection of Air Leaks
Authors: Bari Aicha , Lamoureux-Lévesque Rémi , Ahmed Si Ahmed , Brousseau Jean , Bahloul Ali , Clothilde Brochot , Yaddaden Yacine , Maldague Xavier
Published: March 2023

The presence of leaks in N95 masks represents a major issue and increases the risk of contamination. Usually, detecting these leaks is achieved manually and using expensive devices. The methods presented in this paper aim to automatically detect and locate leaks in N95 masks using recorded thermal image sequences. It is achieved by detecting the temperature variations on the skin around the N95 mask. These variations are closely related to leaks and are caused by breathing. The first proposed approach consists in processing the infrared digital images where traditional methods such as superposition and subtraction are employed. The second one employs a deep neural network architecture trained with labelled data before performing leak detection
Effects of region of interest on breast cancer detection using CNN and infrared imaging
Authors: Gonçalves CB , Prado Domingos AC , Yousefi B , Souza JR , Fernandes H
Published: March 2023

Breast cancer is one of the most common type of cancer that affects woman in the World. It affects millions of women every year killing hundreds of thousands yearly. Early detection of this disease is essential for improving chances of cure and recovery of the patients, thus, one of the most important factors in patients’ treatment is early detection. Mammography, the golden standard for detection this disease is not always 100% effective, which means that it is not always recommended.In this sense, infrared imaging is a promising technique that might be used as a complementary examination technique in a computer-aided diagnosis system. In this work we used genetic algorithms and convolutional neural networks to classify images from the DMR-IR public database. We analyzed both the entire image and only the breast region. Best results were F1-score of 0.92 for entire images and 0.90 for breast regions
Numerical and Experimental investigations of pulsed infrared Thermography for damage detection in Honeycomb Sandwich Composites
Authors: Unnikrishnakurup S , Zheng J , Manzano C , Ngo CY
Published: March 2023

This paper investigates the inspection and testing of internal structural damages in Honeycomb Sandwich composites by means of pulsed thermography experiments. The voids, delamination flaws, and epoxy-filled defects are also studied using numerical simulation in 3D FEM using COMSOL Multiphysics. Pulse thermography data processing methods such as Thermographic Signal Reconstruction (TSR) techniques, Pulse Phase Thermography (PPT) and Principle Component Analysis(PCA) were used to analyse the simulated and experimental data. Standard samples made of Nomex and fiberglass cores, both of which had identical flaws, were studied. The potted core defect, filled with epoxy, and the pillow insert (delamination)located in the front face plate of the composite could be clearly identified from the thermograms as well as the TSR results.On the contrary, the machined core defects showed very minute contrast and are more diﬀicult to be identified
Application of Newton's cooling model to interpret thermoregulation in the breast using dynamic infrared thermography
Authors: Ramírez-Gaviria A F , Vanegas-Montoya D A , Medina-Barreto M H , Bustamante-Mejía J
Published: March 2023

In this work was studied the thermo regulation process on skin breast using the dynamic infrared thermography(DIRT), there were captured sixty images on the chest region in a controlled closed space. The DIRT technique was used for getting an image each thirty seconds after cooling the breast with a conventional fan for 5 minutes. An algorithm implemented in Matlab permitted aligning, segmenting and verifying Newton's cooling model in order to compute the thermal proportionality coefficient in both breasts through average temperatures. A high coefficient Pearson's coefficient near to 0,96 was obtained in all cases
DETERMINING THERMAL ANISOTROPY OF WOODS USING ACTIVE INFRARED THERMOGRAPHY
Authors: Rodríguez F , Victoria S , Marín E , Bedoya A
Published: March 2023

Woods can have anisotropic thermal properties whose knowledge can be of importance for applications where heat transfer plays an important role. Here, we use laser-spot active infrared thermography in a front detection configuration to non destructively quantify the thermal anisotropy in different kinds of woods by determining their entire thermal properties components tensor. The used method takes advantage of heat losses by conduction from the sample to its surrounding air to recover both the thermal conductivity and the diffusivity from a single measurement along any spatial direction. From these parameters, volumetric heat capacity and effusivity can be calculated using well-known relationships
Tax сontext in the structure of corporate social responsibility
Authors:   Siberian Federal University, Demin Alexander V.
Published: March 2023

The article analyzes the issue of including tax issues in the concept of corporate social responsibility. The author defines corporate social responsibility as a voluntary acceptance of obligations by a company that go beyond strictly formal compliance with the letter of the law and maximize profits as a fundamental goal of corporate activity, but based on society’s expectations and universal ethical values. Within the framework of this concept, we are talking about responsibility not only (and not so much) to the state, but to the society as a whole. Can you remain a socially responsible corporation and still not pay your “fair share” of taxes? Does society have the right to impose tax requirements on businesses that go beyond the letter of tax laws? And what does proper tax compliance mean in the context of corporate tax liability? The author answers in the affirmative. The widespread introduction of ideas and principles of corporate social responsibility into tax strategies of modern business, accompanied by the introduction of ethical components in the tax sphere, can significantly increase the level of tax compliance both within individual countries and at the level of the world community. The main thing here is the understanding that the key needs, values, ideals and perspectives of the entire society (and not just the interests of interconnected market players) should be included in everyday business practices. After all, by supporting “sustainable development” in the context of CSR, each corporation creates the conditions for its own development. Obviously, the widespread introduction of ideas and principles of corporate social responsibility into the tax strategies of modern business, accompanied by the introduction of ethical components in the field of taxes, can significantly increase the level of tax compliance both within individual countries and at the level of the global community.
Criminological analysis of the identity of a fraudster in the field of misuse of electronic means of payment
Authors:   Kazan Federal University, Talan Maria V. , Shavaleev Bulat E. ,   Kazan Law Institute of the Ministry of Internal Affairs of Russia
Published: March 2023

The processes of digitalization and technologization developed the social relations, but also acted as a catalyst for the development of illegal activities. A typical example of a crime of this group is fraud using electronic means of payment. Based on the low detection rate of this crime, about 30 %, according to the Ministry of Internal Affairs of Russia, as well as the high degree of latency of illegal banking transactions, the optimization of preventive activities is of particular relevance, which requires research the personality of the offender. Within the framework of this article, the socio-demographic, socio-role and socio-psychological substructures of the offender’s personality are analyzed. The official statistics for the period 2013–2020 were studied, as well as the judicial practice in the amount of 115 verdicts in criminal cases for the same period. The typical gender of the offender, his age, education and territory of residence, his professional affiliation were established. The analysis of the socio-psychological substructure of the personality made it possible to produce a conclusion about the depth and stability of the criminalization of the offender, as well as his criminal motivation. As a result of a comprehensive study, a criminological portrait of the personality of a fraudster in the field of misuse of electronic means of payment was compiled, contradictions were revealed between the portraits of the personality of a general criminal fraudster and a cybercriminal formed in the doctrine of criminology with the data obtained. The results of the study can be used in the framework of improving the prevention of crimes committed using information technology in general, and the misuse of electronic means of payment, in particular.
TRANSFORMATION OF ELECTORAL EXPECTATIONS OF RUSSIANS DURING THE COVID-19 PANDEMIC: RESULTS OF SOCIAL MEDIA ANALYSIS
Authors:   Financial University under the Government of the Russian Federation, BRODOVSKAYA ELENA , LUKUSHIN VLADIMIR ,   Financial University under the Government of the Russian Federation
Published: March 2023

The article presents the results of applied political research on the phenomenon of transformation of electoral expectations of Russian citizens during the COVID-19 pandemic. The context of the study is due to serious changes in public sentiment, formed under the influence of the negative effects of the pandemic. In the context of large-scale restrictions and increased volatility of political processes, among the key trends in the development of electoral expectations, the demand of citizens for the development of social institutions of the state and the development of new forms of social projects is fixed. Consequently, the subject of close attention of modern Russian researchers is the dynamics, structure and content of the processes of transformation of the electoral expectations. The category ‘socially-oriented information flow’ introduced in the framework of this study combines a set of open digital footprints of Internet users that reflect the declaration of these social requirements. The research methodology is based on the use of a hybrid strategy and a combination of modern methods of social media predictive analytics: cognitive mapping of digital content, automated social media analysis of information flows and event analysis. Based on the results of the study, the authors made a conclusion about the formation of a trend of «social turn» in the development of electoral expectations of Russian citizens. During the COVID-19 pandemic, a fourfold increase in socially oriented information flow was recorded, which is popular among all age groups. Based on the selection of digital markers, the authors determined the most common value-ideological models in the information space, the conditions for the formation of a new «social contact» in Russia, as well as the role of various political actors in the articulation of public demands. The study determined the relationship between the dominant social and political requirements and the development of electoral processes, acting as a catalyst for these changes. The low degree of politicization and radicalization of public expectations testifies to the demand for maintaining the stability of political processes while changing the vector and content of social and economic policy.
IMPORT DEPENDENCY VS PUBLIC OPINION: EVIDENCE-BASED READINESS RESEARCH OF THE EU COUNTRIES TO INTRODUCE NEW RESTRICTIVE MEASURES AGAINST RUSSIAN ENERGY CARRIERS
Authors:   St. Petersburg State University, KONDRATENKO KONSTANTIN
Published: March 2023

The article is devoted to the study of the positions of the EU countries of readiness or unwillingness to join new restrictive measures against Russian energy carriers. The topic of blocking Russian raw materials is one of the most painful problems that arose as a result of the Ukrainian crisis. Many leaders and high-ranking officials of the EU countries expressed clear concern about the possibility of an economic shock as a result of the expansion of sanctions. The article, therefore, is devoted to the study of the factors of developing a political position and the role of evidence-based politics in this process. The key issue in the article is the contradiction between values and interests in the member states of the European Union - for this, a study was undertaken of the general behavior of the EU countries, public opinion, basic interests, as well as strategies to overcome the energy impasse. In order to achieve the required results, correlation and regression analysis, as well as qualitative comparative analysis based on Boolean algebra, was undertaken in the article. Cases were studied from the position of acceptable diversity, so economic, political, social and political-cultural variables were selected to obtain the results. The study of the evidence base as the basis for developing a political position and tools for its implementation is important for understanding the emerging energy strategy of the European Union, which will determine the development of the Eurozone in the coming years and possibly decades.
International literature characteristics and hotspots evolution of the impact of climate change on cotton: A bibliographic study
Authors: Li Na , Liang Jiaping , Yang Qiliang , Du Tianmu
Published: March 2023

This study uses information visualization analysis software to quantitatively analyze the literature characteristics and hotspot evolution in the field of research on the impact of climate change on cotton. The results showed that the number of literature was on the rise, and environmental sciences, agronomy, plant sciences, water resources and agriculture were the main disciplines in this field. Countries and regions such as China, the U.S.A, Argentina, Pakistan and India pay great attention to the research field, and the cooperation between countries was relatively closed. Many well-known institutions such as the Chinese Academy of Sciences, University of Agriculture Faisalabad, Nanjing Agricultural University and United States Department of Agriculture-Agricultural Research Service were committed to research in this field. ‘Yield’, ‘CO2’, ‘Adaptation strategy’, ‘Irrigation’, ‘Model’, etc., were the hot words in the research. Research hotspots had developed from the research on assessing the impact of climate change on future cotton production to focus on the impact of CO2 concentration on cotton production, coping strategies for cotton industry development under climate change and climate-smart agriculture issues.
The Value of Emerging Prostate Cancer-associated lncRNA PCGEM1 in
Various Tumors
Authors: Lv Xing , Zhang Mingzhu , Xu Wen
Published: March 2023

Background:

LncRNA not only plays an auxiliary role as an intermediate carrier of genetic
information, but also mediates various regulatory functions. The complex and precise regulatory function
of lncRNA in development and gene expression has greatly explained the complexity of the genome,
and also opened a new avenue for people to understand the complexity of life from the dimension
of gene expression. Long non-coding RNA (lncRNA) prostate cancer gene expression marker 1
(PCGEM1) is a characterized oncogenic lncRNA in different cancers. This review is dedicated to
summarizing the various molecular mechanisms of PCGEM1 and demonstrates that the biological
functions exerted by PCGEM1 are good starting points for therapy.

Methods:

The molecular mechanism of PCGEM1 acting on tumors has been summarized by reviewing
the literature available on PubMed.

Results:

The expression of lncRNA PCGEM1 is abnormally increased in all kinds of tumors, including
cervical cancer, prostate cancer, renal carcinoma, gastric cancer, lung cancer, ovarian carcinoma,
cough variant asthma, and castration tolerant prostate cancer. Besides, PCGEM1 mediates multiple
processes involved in carcinogenesis, including proliferation, invasion, anti-apoptosis, and migration.

Conclusion:

The potential of PCGEM1 as a therapeutic target for cancer is revealed.
New Psychometric Strategies for the Evaluation of Affective, Cognitive,
and Psychosocial Functioning in Unipolar versus Bipolar Depression:
Impact of Drug Treatment
Authors: Guerrera Claudia Savia , Platania Giuseppe Alessio , Varrasi Simone , De Vivo Simona , Pirrone Concetta , Vezzosi Venera Francesca , Tascedda Fabio , Drago Filippo , Di Nuovo Santo , Blom Johanna M.C. , Castellano Sabrina , Caraci Filippo
Published: March 2023

Background:

Different studies have been conducted to understand how patients with unipolar
and bipolar depression differ in terms of cognitive and affective symptoms as well as in psychosocial
function. Furthermore, the impact of antidepressants, second-generation antipsychotics, and mood
stabilizers on these dimensions needs to be characterized, as well as the best psychometric approach to
measure changes after pharmacological treatment.

Objectives:

This study aims to analyze the impact of psychotropic drugs on cognitive, affective, and
psychosocial functioning in MDD and BD patients; to test the sensitivity of psychometric tools for
measuring those changes; also, to understand how psychosocial abilities are associated with affective
and cognitive dimensions in patients with MDD and BD.

Methods:

A total of 22 patients with MDD and 21 patients with BD in the depressive phase were recruited.
Several psychometric tests were administered to assess affective, cognitive, and psychosocial symptoms
before and after 12 weeks of drug treatment (T0 and T1) with different psychotropic drugs including
second-generation antidepressants, second-generation antipsychotics and mood stabilizers (lamotrigine).

Results:

MDD patients showed significant improvement in MoCA, Delayed Recall of Rey’s 15 Words
and HDRS, while a significant worsening was detected on Digit Span Backwards and on FAST scores.
Instead, patients with BD showed significant improvements in the MoCA as the MDD patients, but only
a trend of improvement (non-statistically significant) on the BDI-II. A positive correlation was detected
in both groups between FAST and HDRS and BDI-II scores, especially in BD patients.

Conclusion:

Our results demonstrate that drug treatment with psychotropic drugs can improve cognitive
and affective symptoms, but not all psychometric tools may be equally sensitive to detect those
changes in MDD vs. BD patients. Moreover, we found that affective and cognitive dimensions can be
considered as different psychopathological dimensions both in unipolar and bipolar depression.
Pharmacological Progress of Mitophagy Regulation
Authors: Sehgal Sheikh Arslan , Wu Hao , Sajid Muhammad , Sohail Summar , Ahsan Muhammad , Parveen Gulnaz , Riaz Mehreen , Khan Muhammad Saleem , Iqbal Muhammad Nasir , Malik Abbeha
Published: March 2023

With the advancement in novel drug discovery, biologically active compounds are considered
pharmacological tools to understand complex biological mechanisms and the identification of potent
therapeutic agents. Mitochondria boast a central role in different integral biological processes and mitochondrial
dysfunction is associated with multiple pathologies. It is, therefore, prudent to target mitochondrial
quality control mechanisms by using pharmacological approaches. However, there is a scarcity of
biologically active molecules, which can interact with mitochondria directly. Currently, the chemical
compounds used to induce mitophagy include oligomycin and antimycin A for impaired respiration and
acute dissipation of mitochondrial membrane potential by using CCCP/FCCP, the mitochondrial uncouplers.
These chemical probes alter the homeostasis of the mitochondria and limit our understanding of the
energy regulatory mechanisms. Efforts are underway to find molecules that can bring about selective removal
of defective mitochondria without compromising normal mitochondrial respiration. In this report,
we have tried to summarize and status of the recently reported modulators of mitophagy.
Recent Updates on the Management of Human Papillomavirus-related
Cancers
Authors: Karikalan Barani , Chakravarthi Srikumar
Published: March 2023

Cervical cancer incidence and mortality rates have been steadily decreasing in developed
nations owing to the excellent screening programs executed. However, it still remains one of the
most prevalent tumors in developing nations, contributing significantly to cancer-related mortality in
females. The major causal factor in the genesis of cervical cancer is recognized to be human papillomavirus
(HPV) infection. The female population, particularly in poor countries, is highly susceptible
to HPV infections and cervical cancer as a result of the increasing costs posed by widespread
cervical screening and HPV vaccination methods. Understanding the roles of HPV oncoproteins (E6
and E7) and non-coding RNAs, along with their many cellular targets, can help us develop targeted
drug therapy to manage cervical cancer. In the hunt for novel ways for effective disease control and
prevention, new insights and methodologies in molecular biology keep evolving continuously. In the
recent past, newer studies have revealed deeper knowledge of HPV-activated molecular signaling
pathways as well as prospective targets for early diagnosis, prevention, and therapy of HPV-related
malignancies. Also, there has been much new research conducted on genome-editing tools for HPVinduced
cervical cancer treatment in conjunction with other treatment strategies, such as immunotherapy
and therapeutic vaccines.
Analysis of Microbial and Physicochemical Properties of Raw and
Pasteurized Milk at Some Selected Areas of Tangail District, Bangladesh
Authors: Dey Dipa , Sharmin Saima , Mahmud Shahin , Ali Md. Firoz , Mia Md. Younus
Published: March 2023

Objectives:

The aim of this study is to analyze the microbial quality and physicochemical
properties of raw and pasteurized milk from Tangail District of Bangladesh.

Methods:

A rigorous study was carried out from April - August 2019 at the Tangail District of
Bangladesh for investigation. A total of 18 samples were examined by following the standard
bacteriological methods and by using a refractometer and digital pH meter.

Results:

The results revealed that the highest log of Total Viable Count (TVC) was found as 6.9
and 8.7 CFU/ml in raw and pasteurized milk, whereas the highest log of Total Coliform Count
(TCC) was found as 4.4 and 6.3 CFU/ml in raw and pasteurized milk, respectively. When the
mean value is greater, then the mean value is displayed on the graph as a logarithm. The highest
log of Total E. coli Count (TE.cC) was 6.6 and 6.4 CFU/ml in raw and pasteurized milk, whereas
the highest log of Total Staphylococcus Count (TSC) was found as 7.6 and 6.5 CFU/ml in raw
and pasteurized milk, respectively. The highest mean pH value was 7.43 and 7.19 in raw and
pasteurized milk and the greatest mean value of Total Soluble Solids (TSS) was found as 6.33
and 10.33% in raw and pasteurized milk.

Conclusion:

It can be summarized that both the raw and pasteurized milk bear higher microorganisms
than standards. It might hurt consumers in the long term. So, the milk producers should
be trained up properly and the apposite authority should inspect hygienic conditions around milk
production and processing and marketed milks to ensure the minimal legal requirements.
In vitro Anti-inflammatory Activity with Ethanolic Leaf Extracts of Rivea
hypocrateriformis LPS Stimulated Raw 264.7 Macrophages
Authors: Nachiar Shanthini , Ramachandran Pathangi Kumar
Published: March 2023

Aims:

To investigate the effect of R. hypocrateriformis extract on the production of proinflammatory
cytokines by macrophages.

Background:

The whole plant was extracted with ethanol at room temperature. The in vitro antiinflammatory
activity of RH was investigated on lipopolysaccharide (LPS)-stimulated RAW264.7
macrophages.

Objective:

LPS-induced nitric oxide (NO) production was determined by the Griess method. Production
of pro-inflammatory cytokines including Interleukin-1 beta (IL-1 β), Interleukin-6 (IL-6),
tumor necrosis factor-alpha (TNF-α), and cyclooxygenase-2 (COX-2) was examined using reverse
transcriptase - polymerase chain reaction (RT-PCR) and Western blot analysis. Under in vitro conditions,
RH in doses ranging from 6.25 - 100 μg/mL significantly inhibited lipopolysaccharideinduced
nitric oxide production and the production of pro-inflammatory mediators.

Methods:

In vitro determinations of the toxic effects of unknown compounds have been performed
by counting viable cells after staining with a vital dye. Alternative methods used are the measurement
of radioisotope incorporation as a measure of DNA synthesis, counting by automated counters,
and others that rely on dyes and cellular activity. The MTT system is a means of measuring the
activity of living cells via mitochondrial dehydrogenases. The MTT method is simple, accurate, and
yields reproducible results.

Results:

In this study, we investigated whether R. hyocrateriformis can inhibit the production of
pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) in LPS-activated macrophages. In addition to its
pivotal role in many body functions, NO has also been implicated in the pathology of many inflammatory
diseases, including arthritis, myocarditis, colitis, and nephritis.

Conclusion:

R. hypocrateriformis extract suppressed the pro-inflammatory cytokine production in
LPS-stimulated RAW264.7 macrophages. Hence, R. hypocrateriformis extract is a potential candidate
for the development of pharmacological agents useful in the treatment of inflammatory diseases.
Further research on the effects and molecular mechanisms of the active compound in the extract
is needed to precisely define thestructure-activity relationship in various molecular regulatory
mechanisms.
Effects of Community-potential Factors on the Quality of Life of Urban Elderly of Bangkok Metropolitan
Authors: Thongsri Praleena , Jai-Aree Apichart , Srisuantang Sunti
Published: March 2023

Background:

The population structure in Thailand has changed to an elderly society. The promotion of quality of life for the urban elderly is essential in order to prepare them to become sustainable community members.

Objective:

This study aimed at evaluating the effects related to the community-potential factors on the quality of life of urban elderly and developing the guidelines for the capacity of the community to enhance the quality of life of urban elderly.

Methods:

A mixed-method approach was utilized in two steps. In the first step, quantitative data were collected from 56 elderly people and their caregivers living in an urban area. This data were analyzed by descriptive statistics, Pearson’s correlation coefficient, and stepwise multiple regression. In the second step, the qualitative data were also gathered with a semi-structured interview and community surveys from 36 key informants consisting of community leaders, elderly people, partner agencies, community representative groups, public-sector agencies, educational institutions, and people from the civil-society sector to form a focused group in order to analyze their strengths, weaknesses, opportunities, and threats (SWOT). Content analysis was carried out to analyze this data.

Results:

The levels of quality of life among the elderly living in the Chan-Kasem community were high. The community potential factors influencing the quality of life of the urban elderly were also high. Results of regression analysis showed that one variable factor affected the quality of life in the elderly (12.6%).

Conclusion:

Three guideline themes for determining the capacity of the community to enhance the quality of life of the urban elderly were found: 1) building a community network and a community learning process to generate a volunteer group in order to incorporate and solve the elderly’s problems, 2) increasing the capacity and promoting the livelihoods of the elderly, and 3) constructing elderly awareness as a valuable human resource of the community.
FACTORS AFFECTING FARMERS' DECISIONS TO APPLY HYDROPONIC SYSTEMS IN TARAKAN CITY
Authors: Machmuddin Nurlela
Published: March 2023

Tarakan City has limited agricultural land potential and is less productive so that most of the consumption needs for vegetables are imported from outside the island of Tarakan. It is hoped that with the development of hydroponic technology, the community can meet the needs of vegetables independently. The purpose of this study was to determine the factors that influence the decision of farmers to implement a hydroponic system. The research is located in Tarakan City with the research period from April to October 2021. The method of determining respondents was carried out intentionally to 40 respondents with the consideration that the community had obtained information about hydroponic system, either through direct agricultural extension workers, from friends or through other electronic media. such as television, YouTube, Facebook and other social media. To find out the factors that affect farmers' opportunities to apply hydroponic system, an analysis is carried out using the logit function approach. Analysis of the factors that influence farmers' decisions to apply hydroponic system using logit regression function analysis obtained a Nagelkerke R2 value of 0.494 meaning that the variation of the independent variables included in the model was able to explain 49.4% of the existing phenomena and the remaining 50.6% was explained by other variables. The variable hydroponic planting experience (X4) has a significant and significant effect at the 5 %, meaning that the more often people cultivate hydroponic plants, the greater the opportunity to apply hydroponic system, while age (X1), formal education (X2), Membership Dummy in the farmer group (X3), and Dummy nutrient costs (X5) are not significant. One of the obstacles for farmers in applying hydroponic system is the cost of purchasing nutrients.
DEVELOPING STRATEGIES OF AGROTOURISM X
Authors: Hasanah Ajeng Uswatun , Riana Fitria Dina , Meitasari Deny
Published: March 2023

Agrotourism is a series of tourism activities related to optimizing the potential of agriculture as a tourist attraction. The development of agrotourism can be done with resources, increasing the income of farmers or local communities, and choice preposition. Currently, agrotourism is widely spread in various regions, one of which is Agrotourism X. As a new business unit, Agrotourism X experienced various obstacles including a less strategic business location, facilities, infrastructure that agreement not maximized, limited agrotourism area, capital sourced from personal funds, and choice activities carried out were still not optimal. This study uses descriptive statistical analysis. The criteria for respondents in this study were tourists who had visited Agrotourism X and consumed the product at least once. The data collection technique was carried out by interviewing as well as using a questionnaire with an online questionnaire instrument via Google Form. Processing of research data is carried out using SWOT analysis and QSPM (Quantitative Strategy Planning Matrix). The priority that can be applied based on the QSPM analysis to be implemented is product development. This strategy has the highest TAS value among other alternative strategies, which is 7.5 based on developing product or second strategy.
ANALYSIS OF SOCIO-ECONOMIC OF TOBACCO FARMERS IN PROBOLINGGO REGENCY EAST JAVA INDONESIA
Authors: Wisnujati Nugrahini Susantinah , Patiung Markus
Published: March 2023

The interest of tobacco ranchers in the Probolinggo Regency has forever been unsure because of changes in the cost of creation factors and tobacco items, affecting tobacco ranchers' pay and financial circumstances. The motivation behind the review is (1) to Analyze the pay of tobacco ranchers; (2) to Analyze the elements that influence the pay of tobacco ranchers. (3) Analyze the social states of tobacco ranchers. The strategies utilized in this study are specific techniques with R/C proportion investigation instruments and relapse examination. According to this review (1), the typical pay of tobacco ranchers in the Probolinggo rule added up to Rp 18,540,000/ha/developing season with an RC proportion = 1.6. (2 Factors that influence the pay of tobacco ranchers are land lease, ZA cost, urea cost, and pesticide cost. (3) Based on research, 83% of tobacco ranchers own their homes and are incredibly durable dividers for the responsibility for merchandise utilized daily, such as fridges, TVs, and handphones. For vehicle possession, which is utilized to work and drop off from school, 57% use bikes, 28% use cruisers, and 14.29% use vehicles. Rata-normal wards of the rancher family at most is 3, to be specific, two youngsters and one spouse. Tobacco ranchers are OK with the climate; this is described by their functional improvement of a water system to clean the general climate, building love offices, and socialization spots to interface kinship. It demonstrates that the financial states of tobacco ranchers are satisfied and prosperous.
THE INFLUENCE OF PRODUCT ATTRIBUTES, CONSUMER ATTITUDE AND CONSUMER INTEREST ON THE PURCHASE DECISION OF LOCAL ORANGE FRUIT IN MALANG CITY
Authors: Eldisthia Erika , Setiawan Budi , Muhaimin Abdul Wahib
Published: March 2023

This study aims to determine the effect of product attributes, consumer attitudes and consumer interest on purchasing decisions of local citrus fruits on consumers in Malang City. This research method is descriptive quantitative using Structural Equation Modeling (SEM) analysis with Warp Partial Least Square (WarpPLS) approach. Primary data was obtained through filling out a questionnaire as an online interview media. Meanwhile, secondary data was obtained through literature studies from various related sources. Sampling was done based on non-probability sampling technique and 124 samples were selected as respondents in this study. The results showed that product attributes had a positive and significant effect on consumer attitudes and interests, consumer attitudes had a positive and significant effect on purchasing decisions, and positive and significant consumer interest on purchasing decisions.
Influence of Temperature and Pressure on the Evaporation of 6-Aminopenicillinic Acid
Authors:   Program Studi Teknik Kimia, Fakultas Teknologi Industri, Institut Teknologi Bandung, Aliwarga Lienda , Kusumo Widhi Setyo ,   Program Studi Teknik Kimia, Fakultas Teknologi Industri, Institut Teknologi Bandung, Pramono Agung ,   Program Studi Teknik Kimia, Fakultas Teknologi Industri, Institut Teknologi Bandung
Published: March 2023

6-aminopenicillinic acid (6-APA) is the raw materials for producing semi-synthetic penicillin. In commercial scale, penicillin G is conversed into 6-APA enzymatically by penicillin acylase. Due to the nature of equilibrium reaction, the products are in mixture solution of penicillin G, 6-APA, and phenil acetic acid (PAA). In order to purify the targetted 6-APA, steps of evaporation, crystallisation, and drying are thereby compulsory. In this research, the optimum operation conditions for model solution evaporation were observed. Operation variables, like temperature was varied in the range between 30-65°C at -100mmHg, and pressure was also set between -300 and -50mmHg at constant temperature of 50°C. The results showed that temperature is a dominant factor determining the yield of 6-APA, compared to vacuum pressure from -300 mmHg to -50 mmHg that provided similar yield value. This fact was supported by interpretation of the crystal’s purity for the pressure variation that overall was more than 90% (suggested the homogeneity and higher 6-APA content); hence, operation in each pressure for that range is feasible. To conclude, at 50°C and evaporation pressure of -100mmHg, the highest 6-APA yield and total yield of 97.46% and 91.76%, respectively, were attained.
Clinical Characteristics of Benign Paroxysmal Positional Vertigo Positive on Bilateral Dix-Hallpike Test
Authors: Jo Youngrok , Lee Gun Min , Cho Youn Jin , Kim Mi Joo , Kim Minbum
Published: March 2023

Objectives: The purpose of this study is to investigate the clinical characteristics of benign paroxysmal positional vertigo (BPPV) which showed torsional nystagmus on bilateral Dix-Hallpike test, and to analyze the clinical features of pseudo-bilateral BPPV.Methods: This study is a retrospective chart review of a total of 341 patients diagnosed with BPPV of posterior canal (PC-BPPV). Among them, patients who showed torsional nystagmus on bilateral Dix-Hallpike test were defined as “bilateral DixHallpike positive patients,” who were classified into true- and pseudo-bilateral PC-BPPV group through analysis of nystagmus direction. And pseudo-bilateral PC-BPPV were categorized into two subtypes according to their pathomechanisms. Clinical characteristics including sex, age, underlying vestibular disorders, recurrence and the number of Epley maneuvers were analyzed. Student t-test and Mann-Whitney U-test were used for statistical analysis.Results: Among 341 patients, 27 patients (7.9%) were “bilateral Dix-Hallpike positive patients”. They received more Epley maneuvers than the group of unilateral PC-BPPV until the resolution of nystagmus (2.3 vs. 1.4, p＜0.001). Fifteen patients out of 27 were diagnosed with pseudo-bilateral PC-BPPV, who were classified into two subtypes according to their pathomechanisms. The number of Epley maneuvers was not different between true- and pseudo-bilateral PC-BPPV.Conclusions: Patients with pseudo-bilateral PC-BPPV were common among “bilateral Dix-Hallpike positive patients.” For their better treatment, understanding of possible pathophysiology, accurate Dix-Hallpike test and detailed analysis of nystagmus direction are necessary.
Visual Fixation-Induced Hemi-Seesaw Nystagmus
Authors: Kim Hyun Sung , Oh Eun Hye , Choi Jae-Hwan
Published: March 2023

Seesaw nystagmus (SSN) is characterized by conjugate torsional nystagmus with opposite vertical components in the two eyes. The waveform may be pendular or jerk (hemi-seesaw nystagmus, HSSN), in which the slow phase corresponds to one half-cycle and the quick phase to the other. Pendular SSN and HSSN have distinct clinical presentations and underlying causes. The pathophysiology of pendular SSN may be instability of visuovestibular interactions, while the underlying mechanism for HSSN may be related to the ocular tilt reaction or an imbalance in vestibular pathways. We report a patient with HSSN due to unilateral mesodiencephalic infarction that becomes apparent during visual fixation only.
Dedicated to the memory of V.D. Aleksandrov Effect of annealing in an inert atmosphere on the electrical properties of crystalline pentacene films
Authors: Yurasik G. A.  , Kulishov A. A.  , Givargizov M. E.  , Postnikov V. A.
Published: March 2023

The results of a study of the effect of annealing at 150^oC in an inert atmosphere (Ar + 5% H2) on the electrical properties of organic field-effect transistors based on pentacene are presented. Crystalline pentacene films with a thickness of 95±5 nm were obtained using thermal vacuum deposition. The transfer and output characteristics of field-effect transistors before and after annealing for 15 hours are investigated. It was found that as a result of heat treatment, the hole mobility in the saturation regime increased by an average of 30%, and the threshold voltage decreased approximately two times. According to the data of atomic force microscopy, annealing led to a more than twofold decrease in the surface roughness of pentacene films, as well as to a noticeable enlargement of grains, which led to a decrease in the concentration of traps for hole electric transport in the channel of the field-effect transistor. Keywords: pentacene, vacuum thermal deposition, crystalline films, organic field-effect transistors, hole mobility, annealing in an inert atmosphere.
Spectrophotometric and Spectrofluorimetric Quantification of Urea via Silver Nanoparticles Prepared by Wet Chemical Method
Authors: Ismail Muhammad
Published: March 2023

Silver nanoparticles have been utilized in an easy, sensitive, and effective approach through spectrophotometry and spectrofluorimetry to quantify urea in water samples. Here, 1,3-di-(1H-imidazole-1-yl) -2-propanol (DIPO) was employed to stabilize Ag NPs produced from the reduction of aqueous silver nitrate by sodium borohydride (NaBH4). Beer-Lambert's law was applied for determination using the complexation of Ag NPs with urea molecules. The results show urea can be assessed concurrently with good results and percent recoveries. The UV-visible absorbance and fluorescence emission calibration curves were plotted at 445 and 471 nm wavelengths, respectively. Beer-Lambert’s law was obeyed in the 0.1-15 mM concentration range. A linear correlation for both UV-visible spectrophotometry and spectrofluorimetry was obtained on optimum conditions using the suggested methods having a limit of detection (LOD) was found to be 0.897 and 0.048, respectively. The percent recovery ± RSD by the spectrophotometric and spectrofluorimetric method was found to be 88 ± 19.7%, 96.67 ± 21.53%, 130.8 ± 1.33% and 102.3 ± 12.7%, 97.26 ± 5.63%, 111.4 ± 3.8%, respectively. Following a comparison of the obtained data, it may be possible to identify spectroscopic approaches with greater efficacy and efficiency that may be used to determine urea's presence in actual samples of biological and non-biological fluids.
Contexto de cadena fríjol
Authors: Ortiz Flórez Sebastián Alejandro
Published: March 2023

En esta ficha de contexto se mencionan los aspectos importantes de la cadena de fríjol enfocados a su marco productivo, regional, económico, comercio internacional, así como sus perspectivas y tendencias frente al mercado, dando a conocer su entorno de Ciencia y Tecnología e Innovación.
Contexto de cadena apícola
Authors: Yepes Vargas Luz Andrea
Published: March 2023

En esta ficha de contexto se mencionan los aspectos importantes de la cadena apícola enfocado a su marco productivo, regional, económico, comercio internacional, así como sus perspectivas y tendencias frente al mercado, dando a conocer su entorno de Ciencia y Tecnología e Innovación.