bluuebunny/crossref_metadata_2025 huggingface dataset:
Análisis de tensiones en tres tipos de diseños de implantes dentales a nivel de la interfase hueso-implante mediante el método de elementos finitos
Authors:   , Campos Merizalde Valeria Noemi
Published: February 2024

El desarrollo de materiales que sustituyan a largo plazo una pieza dentaria perdida, es uno de los objetivos con más desafíos que tienen los estomatólogos. Desde el descubrimiento del titanio y de los implantes dentales de titanio, un sustituto artificial biocompatible semejante a la raíz de un diente, que se coloca quirúrgicamente dentro del hueso maxilar y mandibular, se han ido implementando en la práctica odontológica, llegando a ser un tratamiento predecible y exitoso, aumentando su utilización con el paso del tiempo. Un implante dental, está compuesto por dos partes principales: el cuerpo del implante, que es la parte que va a estar en intimo contacto con el hueso adyacente y la parte emergente o plataforma en la cual se va a insertar el pilar protésico. Por otro lado, los implantes tienen distintas características como la superficie, longitud y diámetro, estas influyen en los cambios que se van a dar en la cresta ósea, alrededor del implante y que va a tener cambios en sentido horizontal y vertical. En comparación con una prótesis parcial o total, el implante dental nos trae como beneficios una mejor apariencia, más comodidad del paciente al hablar y comer, devuelven la estética y ayuda a detener la reabsorción ósea. La mandíbula presenta una reacción biomecánica impredecible, los dientes naturales tienen a su alrededor al ligamento periodontal el cual se encarga de amortiguar las fuerzas oclusales, en los implantes el patrón de distribución de estrés se da de manera distinta, para que el tratamiento sea exitoso, estas fuerzas se deben de distribuir de manera homogénea al hueso adyacente, pero al tener el hueso una reacción biomecánica impredecible, se complica el proceso de implantación e integración del implante en la mandíbula, siendo esta la razón por la que puede fracasar…
Aprovechamiento del efluente residual de suero de queso y estiércol de bovino en la producción de biogás y abonos líquidos orgánicos de una planta en Puno-Cabana
Authors:   , Quispe Apaza Nohemi
Published: February 2024

Este estudio investiga el uso del lactosuero y estiércol de bovino en la generación de biogás y biol en reactores artesanales tipo batch que trabajaron en condiciones mesofílicas (20-28 °C) a escala piloto. Se realizaron experimentos de digestión anaeróbica con cuatro tratamientos (T0, T1, T2 y T3) a diferentes dosis y cada uno con tres repeticiones durante 104 días. Los resultados mostraron que la monodigestión del lactosuero se acidificó más que aquellos que contenían estiércol de vacuno. La acumulación de biogás por tratamiento fue del siguiente orden T0 < T1 < T2 < T3. El T3, tuvo mayor producción de biogás. Los coliformes fecales fueron inferiores a lo establecido en el D.S. N°004-2017-MINAM (< 10 NMP/ml). El contenido de nutriente en los abonos líquidos orgánicos en la mayoría de tratamientos aumentó al adicionar el estiércol de bovino, por lo que T2 y T3 presentan mayor cantidad de nutrientes. Según la cantidad de Cu y Zn y de acuerdo con la Norma Chilena (NCh2880.Of2004), el biol pertenece al abono tipo A, sin restricción en su uso. En síntesis, el lactosuero tiene la capacidad de generar biogás y el T3 presentó mayor volumen. Los bioles (T0, T1, T2 y T3) cumplieron con el contenido de nitrógeno (> 700 mg/L) y fósforo (> 170 mg/L), en cuanto al potasio (> 1300 mg/L), el T0 no cumple. El pH ácido del biol puro permite la conservación más prologada del biol, en tanto el pH aumenta al mezclarse con agua antes de su aplicación en cultivos.
Evaluación de las razones albúmina a fibrinógeno y proteína C reactiva a albúmina como marcadores de riesgo cardiovascular en pacientes con Lupus Eritematoso Sistémico
Authors:   , Chaname Arriola Luis Alberto , Juarez Bendezu Joanne Aleska
Published: February 2024

Objetivo: Evaluar las razones AFR y CAR como marcadores de riesgo cardiovascular (RCV) en pacientes con LES. Materiales y métodos: Estudio retrospectivo transversal. Participaron 71 pacientes diagnosticados con LES (Casos) y 51 individuos aparentemente saludables (Controles, CTR). A los grupos se le determinó hipertensión, grado de obesidad, albúmina, parámetros inflamatorios (Fibrinógeno, Proteína C Reactiva, Velocidad de sedimentación Globular, Contaje de leucocitos e IL-6), perfil lipídico, AFR y CAR. Se estimaron medias, diferencias entre grupo por pruebas t Student, sensibilidad, especificidad, valor predictivo negativo (VPN), valor predictivo positivo (VPP) y eficiencia de la curva ROC por área bajo la curva (AUC) de ambas razones. Resultados: LES presentó CAR más alto y AFR más bajo versus CTR (p<0,001). La curva ROC demostró que CAR (AUC= 1,000) presentó una mayor capacidad de discriminar RCV en LES que AFR (AUC= 0,760). CAR tuvo una sensibilidad, especificidad, VPP, VPN de 100% a diferencia de AFR (p<0,001). El valor de CAR y AFR para discriminar RCV fue 0,016 y 13,6, respectivamente. LES en comparación con CTR presentaron un porcentaje mayor de factores de RCV clásico e inflamatorios. Conclusiones: AFR y CAR pueden ser considerados prometedores marcadores para evaluar el riesgo cardiovascular en pacientes con LES; sin embargo, CAR se puede clasificar un marcador excelente para diferencias riesgo cardiovascular en LES de acuerdo con los valores de AUC.
Selección de un floculante natural e implementación a un sistema de tratamiento combinado como alternativa de reutilización de aguas grises en el sector construcción
Authors:   , Otoya Bernaola Freshia Katherine Jesus , Saravia Zuñiga Fiorella
Published: February 2024

La presente investigación tiene como objetivo analizar el comportamiento dos tratamientos a base de penca de O. ficus-indica (TRAT-1) y semillas de M. oleifera (TRAT-2) como floculantes naturales, ambos combinados con carbón activado, para reducir la concentración de los contaminantes de las aguas grises de un proyecto de construcción. Para la determinación de la concentración óptima de los floculantes se trabajó con la prueba de jarras, se obtuvo que ambos tratamientos redujeron la turbidez en un 85% y 87%, respectivamente. Posteriormente al utilizar el filtro de carbón activado con cada floculante se evidenció que el TRAT-2 tuvo una mejor reducción de los parámetros de la calidad de agua en comparación con el TRAT-1, mostrando un mayor potencial de coagulación, además de mejorar varios parámetros de calidad del agua. En conclusión, la semilla de M. oleifera, en combinación con el carbón activado, tiene mayor potencial para reducir la concentración de los parámetros de las aguas grises tales como DBO, DQO, sólidos totales, aceites y grasas y coliformes Termotolerantes.
Exploring the Relationship Between Leadership Behaviour and Firm Performance in the RMG Industry of Bangladesh: The Mediating Role of Competitive Advantage and the Moderating Influences of Emotional Intelligence and Firm Strategy
Authors: Tareque Mohammad Alam , Islam Prof. Nazrul
Published: February 2024

This study delves into the intricate relationship between leadership behaviour and firm performance within Bangladesh's Ready-Made Garments (RMG) industry. Utilising a correlational quantitative approach with surveys from 400 leaders across various managerial echelons, the research uncovers the pivotal role of leadership in shaping firm outcomes. Notably, competitive advantage emerges as a mediator, with emotional intelligence and firm strategy serving as critical moderators.
Three dimensions’ comparison of two hospital centres : Usefulness, ease of use and functional analyses of the information system
Authors: Guetibi Sabrina , Hammoumi Mohammed El , Brito António Carvalho
Published: February 2024

Hospitals globally are increasingly transitioning activities to digital platforms, particularly through Hospital Information Systems. These systems are vital for operational management, necessitating an understanding of professionals' perspectives to facilitate necessary adjustments. This report details a research project analyzing user behavior towards the information system, focusing on two hospital centers in Morocco and Portugal. Utilizing both SPSS for quantitative analysis and NVivo for qualitative insights, data collection spanned 2015–2017. While offering valuable insights into user behavior during this period, it's crucial to acknowledge potential changes in HIS technology and healthcare practices since 2017. The chosen timeframe allows exploration of historical perspectives. The comparison between hospitals enables assessment of cultural, ethical, and professional factors influencing user acceptance and perceived system performance, providing a nuanced understanding of the HIS landscape, incorporating dynamic healthcare practices over time.
Estimating Telecommuting Rates in the US Using Twitter Sentiment Analysis
Authors: Acosta-Sequeda Juan , Mohammadi Motahare , Patipati Sarthak , Mohammadian Abolfazl , Derrible Sybil
Published: February 2024

The COVID-19 pandemic had a significant impact on virtually every human activity. Millions of workers around the globe from eligible professions stayed at home working as part of the measures taken to contain the virus’ spread. The change in transportation demand associated to this phenomenon poses a challenge for cities, especially regarding public transportation, where the decrease in demand arose critical questions on how to assess decreased ridership and potential rebound effects. With this in mind, we ask: can we obtain real-time demand change estimates using social media data? Hence, the aim of this work is to take social media unstructured information and transform it into structured insights that can offer almost real-time estimates on demand trends associated with telecommuting. To achieve this, we obtained around 50,000 geo-tagged tweets relevant to telecommuting in the US. With that, we leveraged transformers Machine Learning methods to fine-tune a language model capable of automatically assigning a sentiment to tweets on this topic. We used the time evolution of the obtained sentiments as covariates in time series forecasting models to estimate telecommuting rates at both the national and state levels, observing a drastic improvement over the estimates without such covariates. Our major finding indicates that it is possible to structure social media data in order to use it to obtain demand change estimates, and that the accuracy of such estimates is going to depend heavily on how much people discuss the topic in question in a determined geography. This finding is in line with others that have found alternative ways of obtaining insights on transportation data, and hence, is a relevant contribution towards real-time data-driven approaches for transportation demand assessment.
Mult-omics Approach-Based Autophagy Pathway Analysis in Alzheimer’s Disease
Authors: Xia Dong
Published: February 2024

Autophagy, as an important cellular protective mechanism, is closely associated with the occurrence and progression of neurode- generative diseases such as Alzheimer’s disease. However, the specific mechanisms underlying autophagy in neurodegenerative diseases remain unclear, and there are still many unknowns regarding its detailed regulation and involvement mechanisms. In this study, we aimed to use a multi-omics bioinformatics approach to integrate large-scale transcriptomic data and identify a series of autophagy key genes, namely CDKN2A, CXCR4, and IFNG, whose expression levels significantly differ between disease pa- tients and normal controls. Additionally, single-cell omics data will be supplemented to further investigate these findings. Our goal is to provide important clues for unraveling the pathogenesis of Alzheimer’s disease and potentially identify novel targets for future therapeutics and diagnostics. Furthermore, by incorporating Mendelian randomization analysis, we will explore the causal relationships between vascular inflammation, depression, and mood fluctuations with Alzheimer’s disease to provide insights into the associations among these related diseases and offer a theoretical basis and clinical application value for their treatment and prevention.
Therapeutic Potential of Physiological Starvation: Impact of Nutritional Support on Autophagy and Inflammasome Dynamics in an Lps-induced Sepsis Model
Authors: Bakır Gizem , Armağan Coşkun , Deliloğlu Burak , Tüfekçi Kemal Uğur , Erdoğan Funda Tüzün , Genç Şermin , Keskinoğlu Pembe , Yılmaz Osman , Duman Nuray , Özkan Hasan
Published: February 2024

Aim: This study aimed to investigate the influence of nutritional support on autophagic activity and inflammatory markers in an experimental sepsis model induced by lipopolysaccharide (LPS) in rats.
Material and Method: Thirty-five male Wistar albino rats were divided into three groups: control, LPS-induced sepsis, and LPS-induced sepsis with nutritional support. Sepsis was induced by intraperitoneal LPS administration, and nutritional support was provided via orogastric tube feeding. Sickness behavior, body weight changes, and molecular markers (NLRP3, Caspase-1, IL-1β, Beclin, LC3) were assessed.
Results: Sepsis induction led to significant weight loss and increased sickness scores, with notable changes in molecular markers. Nutritional support showed a potential influence on NLRP3 and LC3 levels, suggesting a regulatory role in inflammasome activity and autophagy during sepsis.
Discussion and Conclusion: The study sheds light on the complex interplay between sepsis, nutritional support, and molecular markers. Notably, NLRP3 exhibited significant differences, while other markers showed nuanced responses. The findings suggest a potential regulatory effect of nutritional support on the inflammatory response and autophagy during sepsis. Further investigations into temporal dynamics and specific pathways are warranted for a comprehensive understanding of these interactions, offering valuable insights for therapeutic strategies in sepsis.
Ehmt2 Loss-of-function Alterations Cause a Kleefstra-like Syndrome
Authors: Barrero Maria , Martínez-Delgado Beatriz , López-Martín Estrella , Kerkhof Jennifer , Baladron Beatriz , Mielu Lidia , Sanchez-Ponce Diana , Bada-Navarro Ariadna , Matesanz Marina Herrero , Lopez-Jimenez Lidia , Rzasa Jesica , Rots Dmitrijs , Fernandez-Prieto Marta , Hernandez-SanMiguel Esther , Gómez-Mariano Gema , Marin-Reina Purificacion , Cazorla-Calleja Rosario , Alonso Javier , Kleefstra Tjitske , Posada Manuel , Bermejo-Sánchez Eva , Sadikovic Bekim
Published: February 2024

The dysregulation of the epigenetic machinery has been linked to neurodevelopmental defects in humans. One such syndrome is Kleefstra syndrome (KS), which results from heterozygous alterations in the EHMT1 gene, leading to loss of function. EHMT1 and EHMT2 are highly similar histone methyltransferases that play crucial roles in development. Despite their similarity, alterations in EHMT2 have not been previously reported. In this study, we present a pediatric patient exhibiting a phenotype overlapping with KS, harboring a de novo single base substitution in EHMT2. This substitution results in the amino acid change p.Ala1077Ser in the catalytic SET domain, causing a decrease in the affinity of this domain for histone H3 tail and a three- to five-fold reduction in enzyme activity. As part of an advanced diagnostic strategy, we leveraged epigenomics and proteomics data to comprehensively characterize the EHMT2 p.Ala1077Ser variant. Analysis of DNA methylation, histone methylation, and gene expression profiles reveals a substantial overlap between the EHMT2 p.Ala1077Ser variant and KS. Based on these findings, we propose that EHMT2 haploinsufficiency leads to a Kleefstra-like syndrome. While we cannot entirely rule out dominant negative effects caused by the EHMT2 p.Ala1077Ser variant, our data, in conjunction with previously published studies, suggest that the loss of EHMT2 function is more detrimental to cells than the loss of EHMT1. This may explain the rarity of individuals with alterations in EHMT2.
Assessment of mobility of seniors using ‘Timed Up and Go’ test and the risk of falls by means of the Tinetti test in the context of various aspects of life in a population covered by the family doctor care
Authors: Drobnik Jarosław , Roemer-Ślimak Roma , Siekierka Joanna , Grata-Borkowska Urszula
Published: February 2024

Background:
The latest demographic trends show that the number of elderly people will continue to grow dramatically. Mobility is extremely important for seniors because it allows them to remain independent, to participate in the lives of families and communities, and to take part in physical activities. Falls increase the frequency of hospitalization, which negatively affects patients' physical fitness. In the presented study, our goal was to assess the degree of mobility of seniors in the context of various aspects of life. The increasing prevalence of mobility limitations among seniors is a concern because it affects the quality of life of the elderly population.
Methods:
230 patients, who were under the care of a family doctor's clinic, were subject to the test. The tools used in the study were the Tinneti test and Timed UP and GO test. The start of the study was preceded by the consent of the Bioethics Committee of the State Medical Higher Vocational School in Opole No. 10/PI/2019
Results:
The results of our study indicate the existence of relationships, among others: between the status of residence or place of residence and the tendency to falls or functional mobility. The results, which were obtained in our research, cannot be compared with the results from other studies because we have not been able to find analyses on mobility of patients in the contexts we discussed.
Conclusions:
Men constitute a larger group with significant mobility restrictions. People living alone were characterized by greater physical fitness in everyday life. The high level of risk of falls is connected with limited mobility and limited motor functions of the elderly over 75 and seniors living in a village.
Sunlight-powered hovering of an ultra-light micro aerial vehicle
Authors: Qi Mingjing
Published: February 2024

The limited flight duration presents a significant obstacle to the widespread application of micro aerial vehicles (MAVs)1-3, especially for ultra-lightweight ones weighing less than 10 grams, generally having a flight endurance of no more than 10 minutes1,4. Sunlight power5-7 is a potential alternative to improve the endurance of ultra-light micro aerial vehicles, but owing to the restricted payload capacity of the vehicle and low lift-to-power efficiency of traditional propulsion systems, previous studies can not achieve untethered flight or sustaining hovering of MAVs powered by natural sunlight 8,9. To address the challenges, here we present a novel electrostatic-driven propulsion system with ultra-low power consumption (137 mW) and high lift-to-power efficiency (30.7 g·W-1) to realize the first sunlight-powered hovering of a micro aerial vehicle (with a total lift-to-power efficiency of 7.4 g·W-1) under natural sunlight conditions (920 W·m-2). The vehicle mainly consists of an electrostatic-driven propulsion system and an ultra-light kilovolt power system, with a total mass of 4.21 g, which is 1/600 of the existing lightest sunlight-powered aerial vehicle capable of hovering6. The sunlight-powered aerial vehicle we present is the first micro aerial vehicle to achieve untethered flight and sustained hovering under natural sunlight conditions (as opposed to artificial light sources 8,10 and wireless radiofrequency11).
A Scoping Review of Digital Interventions to Improve Communication Between Children and Their Parents
Authors: Bank Sakarias Einar Sefik , Løkkeberg Stine Eileen Torp , Busso Lilliana Andrea Del , Larsson Margaretha
Published: February 2024

Introduction: Parents can struggle with communication with their children. This can cause stress for parents and disturb family functioning. Digital innovations could give parents a tool to relate to and strengthen interactions with their children.
Aims and objectives: This review aims to summarize previous attempts to improve communication and interactions between child and parent/guardian using digital tools and techniques.
Methods: a scoping review approach was used, applying systematic searches and screening methods in Rayyan software. The included studies were then analysed using a narrative review, mapping results onto intervention functions from the behaviour change wheel.
Results: 322 articles were screened, and seven were found to be relevant. Education, coercion, training, and enablement functions were used throughout, with mostly positive results.
Discussion: Although more research is needed, the initial results are positive. Digital innovations can prove useful in promoting communication and improving the interactions between parents and children. Future research is needed with a more varied set of techniques and functions inherent to the innovations.
Implications: Digital innovations may provide a useful, cheap and easy-to-use complement to support parents during child rearing if developed and evaluated systematically and the contents are sufficiently complex and user-friendly.
Sediment load assessments under climate change scenarios - lack of integration between climatologists and environmental modelers
Authors: Szalinska Ewa , Orlinska-Wozniak Paulina , Wilk Pawel , Jakusik Ewa , Skalak Petr , Wypych Agnieszka , Arnold Jeff
Published: February 2024

Increasing precipitation accelerates soil erosion and boosts sediment loads, especially in mountain catchments. Therefore, there is significant pressure to deliver plausible assessments of these phenomena on a local scale under future climate change scenarios. Such assessments are primarily drawn from a combination of climate change projections and environmental model simulations, usually performed by climatologists and environmental modelers independently. Our example shows that without communication from both groups the final results are ambiguous. Here, we estimate sediment loads delivered from a Carpathian catchment to a reservoir to illustrate how the choice of meteorological data, reference period, and model ensemble can affect final results. Differences in future loads could reach up to even 6,000 tons of sediment per year. We postulate there has to be better integration between climatologists and environmental modelers, focusing on introducing multi-model ensembles targeting specific impacts to facilitate an informed choice on climate information.
Perspectives of General Dental Practitioners on Restoring Endodontically Treated Molars: A UK-Based Vignette Study.
Authors: Butt Sadia , Patel Shenil , Kasperek Dariusz , Mowad Emad , Jarad Fadi
Published: February 2024

Aims: To assess and compare how UK general dental practitioners restore endodontically treated molars and what tooth-related factors they consider relevant to their management.
Method: An online cross-sectional vignette survey was sent out to UK dentists via email and the use of social media platforms. Three clinical cases were designed.
Results: 394 participants completed the survey. GDPs showed a preference towards restoring the endodontically treated molars with indirect restorations such as crowns and onlays. Material election varied, with a notable inclination towards gold and lithium disilicate. This was influenced by factors such as the number of remaining tooth walls, thickness of walls, and the presence of parafunction.
Conclusion: Clinicians generally agreed on whether to place a direct or indirect restoration but there was greater disagreement when deciding on the type of restoration and material. Further evidence and education are required to help UK dentists decide more objectively whether to place an onlay or a crown, what material to select, and what prognostic factors are most pertinent to the case.
No Effect of Tattoos on Local Sweat Concentrations of Select Cytokines, Cortisol, Glucose, Blood Urea Nitrogen, or Lactate During Exercise
Authors: Merritt James , Ozga Michal , De Chavez Peter John , Boolani Ali , Baker Lindsay
Published: February 2024

Due to growing interest in the investigation of exercise induced sweat biomarkers to assess an individual’s health and the increasing prevalence of tattoos in the world’s population, investigators sought to determine whether local sweat concentrations and excretion rates of epidermal growth factor (EGF), interleukin (IL)-10, IL-1α, IL-1β, IL-6, IL-8, tumor necrosis factor alpha (TNF-α), cortisol, glucose, blood urea nitrogen (BUN), and lactate differ between tattooed and contralateral non-tattooed skin during exercise. Sixteen recreational exercisers [female (50%)] (age = 25-48yrs) with ≥ 1 unilateral permanent tattoo [median age = 6yrs, IQR = 5] on the arm/torso completed an outdoor group fitness session. There were no significant differences between tattooed and non-tattooed skin for sweat EGF, IL-10, IL-1α, IL-1β, IL-8, TNF-α, cortisol, glucose, BUN, or lactate concentrations. There were no significant differences between tattooed and non-tattooed skin for sweat EGF, IL-10, IL-1α, IL-1β, IL-8, TNF-α, cortisol, glucose, BUN, or lactate excretion rate. Findings suggest that permanent tattoos older than 1 year may not impact local sweat EGF, IL-10, IL-1α, IL-1β, IL-8, TNF-α, cortisol, glucose, BUN, and lactate concentrations or excretion rates during exercise. Clinical trial identifier NCT04920266 was registered on June 9, 2021
Stress drives polymer phase separation and microplastic release
Authors: Wang Jing Jing , Li Dunzhu , Li Peijing , Shi Yunhong , Sheerin Emmet , Yang Luming , Hill Christopher , Sader John , Gordon Conall , Ruether Manuel , Xiao Liwen , Boland John
Published: February 2024

Microplastic release from semicrystalline plastics threaten the environment and human health. We investigated polypropylene and polyethylene plastics, which together account for 54% of the global market. Mimicking common levels of residual stress found in plastics via cantilever beam experiments, we demonstrated that compressive stress drives nano and microscale segregation of amorphous polymer droplets onto the plastic’s surface. Simulations reveal this stress-driven volumetric flow is consistent with that of a Bingham plastic material, with a temperature-dependent threshold yield stress. Flow is thermally activated and stress dependent, with a reduced energy barrier at higher compressive stresses. Transfer of surface segregated amorphous droplets into the surroundings generates microplastics. Studies with water-containing plastic bottles showed that the highly compressed neck and mouth regions were predominantly responsible for the release of microplastics.
Qualitative somatosensory evaluation of recipient and donor sites of subepithelial connective tissue grafts
Authors: Nascimento Esther Belotti do , Jurkevicz Talyta Sasaki , Bonjardim Leonardo Rigoldi , Sant`Ana Adriana Campos Passanesi , Damante Carla Andreotti , Zangrando Mariana Schutzer Ragghianti
Published: February 2024

Objectives
The subepithelial connective tissue graft (SCTG) plus coronal advanced flap is commonly evaluated by clinical parameters, but potential sensory changes (patients’ perception of painful or painless sensations) need to be further explored. This study aimed to qualitatively evaluate the somatosensory profile of recipient and palatal donor sites of SCTG.
Materials and Methods
Sensory tests were applied at SCTG recipient and donor sites at baseline, after 3 and 6 months. A single calibrated examiner applied Douleur Neuropathique 4 questionnaire (DN4), qualitative sensory test (QualST), discriminating the areas as hypersensitive, hyposensitive or normosensitive, and two-point acuity test. Descriptive statistics, non-parametric Kruskal Wallis test for QualST evaluation and ANOVA for Two-point test (p < 0.05) were used.
Results
QualST revealed that recipient areas presented no significant differences in tactile, pressure and thermal tests. Brush test revealed hyposensitivity after 3 months (p = 0.03). In donor areas, only thermal evaluation showed a significant difference (p = 0.01), being hypersensitive after 3 months and hyposensitive after 6 months. At baseline, all evaluations in recipient and donor areas were normosensitive. According to DN4, no patient reported pain in recipient and donor sites. Non-painful sensory perception was reported as numbness in recipient (3.14% of patients) and donor (18.4%) areas. No significant differences were found for two-point acuity test values.
Conclusions
The extent to which these alterations in sensations affected oral functions showed no impairment. Clinical Relevance: Although some punctual somatosensory changes occurred, they did not disable important oral functions, thus reinforcing the positive results obtained with periodontal plastic surgeries.
A SuperLearner approach for predicting diabetic kidney disease upon the initial diagnosis of T2DM in hospital
Authors: Lin Xiaomeng , Liu Chao , Wang Huaiyu , Fan Xiaohui , Li Linfeng , Xu Jiming , Li Changlin , Wang Yao , Cai Xudong , Peng Xin
Published: February 2024

Background Diabetic kidney disease (DKD) is a serious complication of diabetes mellitus (DM), with patients typically remaining asymptomatic until reaching an advanced stage. We aimed to develop and validate a predictive model for DKD in patients with an initial diagnosis of type 2 diabetes mellitus (T2DM) using real-world data. Methods We retrospectively examined data from 3,291 patients (1740 men, 1551 women) newly diagnosed with T2DM at Ningbo Municipal Hospital of Traditional Chinese Medicine (2011–2023). The dataset was randomly divided into training and validation cohorts. Forty-six readily available medical characteristics at initial diagnosis of T2DM from the electronic medical record were used to develop prediction models based on linear, non-linear, and SuperLearner approaches. Model performance was evaluated using the area under the curve (AUC). SHapley Additive exPlanation (SHAP) was used to interpret the best-performing models. Results Among 3291 participants, 563 (17.1%) were diagnosed with DKD during median follow-up of 2.53 years. The SuperLearner model exhibited the highest AUC (0.7138, 95% confidence interval: [0.673, 0.7546]) for the holdout internal validation set in predicting any DKD stage. Top-ranked features were WBC_Cnt*, Neut_Cnt, Hct, and Hb. High WBC_Cnt, low Neut_Cnt, high Hct, and low Hb levels were associated with an increased risk of DKD. Conclusions We developed and validated a DKD risk prediction model for patients with newly diagnosed T2DM. Using routinely available clinical measurements, the SuperLearner model could predict DKD during hospital visits. Prediction accuracy and SHAP-based model interpretability may help improve early detection, targeted interventions, and prognosis of patients with DM.
Nurses’ practice towards Evidence Based Practice in nursing process and associated factors in South Wollo Zone Public Hospitals, Northeast Ethiopia: Mixed Method
Authors: Edmealem Afework , Fentaw Nurye , Bekele Abebe , Tegegne Belachew , Mohammed Jemal , Liknaw Tiliksew
Published: February 2024

Background: Evidence-based practice is clinical decision-making using the best evidence available in the context of individual patients' preferences and clinical expertise. It is serving as a crucial instrument for the health science disciplines to minimize the theory-practice gap. Despite clinical effectiveness and patient safety being among its successes, its practice in the nursing process was low.
Methods: An institution-based-based-sectional study with a mixed method was employed from April 1 to 30, 2023, among 419 nurses for the quantitative part and 15 others for the qualitative part. The data were collected using structured, pretested, self-administered questionnaires. Simple random sampling was used to select participants. The bivariable analysis was done primarily, and variables with a p-value < 0.25 were further examined using a multivariable logistic regression model to control con-founders. Then, variables having a p-value less than 0.05 with a 95% CI were used to declare significantly associated factors.
Result: A total of 434 nurses were involved in this study; 15 of them were for the qualitative part and 419 were for the quantitative part, with a response rate of 100%. Nurses who had poor implementation of evidence-based practice in the nursing process were 191 (45.6%). Participants who were working at general hospitals (AOR = 3.37, 95% CI 1.39–8.18) and comprehensive and specialized hospitals (AOR = 7.29, 95% CI 3.06–17.31), lack of training about evidence-based practice (AOR = 2.50, 95% CI 1.36-4.56), and lack of internet access (AOR = 2.46, 95% CI 1.43–4.23) were factors associated with poor levels of nurses’ practice towards evidence-based practice in the nursing process.
Conclusion: Nurses’ practice towards evidence-based practice in the nursing process was low. Age, working in general hospitals, working in comprehensive and specialized hospitals, lack of training, and lack of internet access were factors that had associations with a poor level of nurses’ practice towards evidence-based practice in the nursing process. Hence, hospital managers give attention to internet access and training about evidence-based practice.
Viral Induced Reactive Plasmacytosis
Authors: Bhatnagar Aishwarya , Joshi Anamika , Morya Kailash Chandra , Kewalia Kailash
Published: February 2024

Plasmacytosis is a condition of increased number of plasma cells in tissues, exudate or blood as a defence mechanism. Transient immune reactions in any infection or autoimmune disorder may present as reactive plasmacytosis that might rarely also manifest as plasma cell mucositis. Reactive plasmacytosis has been reported in several viral infections and has been found to completely disappear within 2 weeks. Complete clinical evaluation, individualised investigation and more specific tests are required to rule out these oral manifestations. Thus, we hereby present an extremely rare condition wherein Human Papilloma Virus (HPV) led to reactive plasmacytosis.