bluuebunny/crossref_metadata_2025 huggingface dataset:
Sobre a escrita acadêmico-científica: o ensaio da perspectiva de pós-graduandos
Authors: Moreira João Vitor , Corrêa Manoel Luiz Gonçalves
Published: January 2025

This article analyzes reading reports produced by students within the framework of a postgraduate course conducted as a workshop on academic literacies. The workshop problema-tized traditionally unquestioned boundaries in science, which, in scientific practice and writing, are marked by the exclusion of subjectivity, personal voice, and opinion, in favor of objectivity, impersonality, and truth. For the reading report, students were asked to compare the guidelines from a technical and scientific writing manual with one of three excerpts from essays written by three authors from different areas of knowledge. This comparison considered formal characteris-tics, including enunciative aspects. The study aimed to investigate students’ perceptions of scientific values, particularly the potential tensions between the manual’s standardizing guidelines and the essay as a genre, which, despite its presence in various fields of knowledge, does not adhere to cer-tain imperatives that govern contemporary academic-scientific writing practices. The analysis and interpretation of 32 reports were conducted from a discursive perspective within applied linguistics. The results highlight students’ observations, particularly: (a) the absence of explicit theoretical sup-port in the essays, which was evaluated in the reports as a deficiency in the essayists' argumentation; (b) the absence of bibliographic references in certain passages; and (c) the prominent presence of the authorial voice in the text, perceived as "freedom" of creation. These three observations reflect a dominant representation of academic-scientific writing among the students.
Comparison of Heavy Metal and Disinfectant Resistance of S. aureus and Enterococcus Isolates with Antibiotic Resistance Profiles
Authors: Acar Bahar Onaran , Şenarısoy Hakan , Keyvan Erhan
Published: January 2025

Antimicrobial resistance is one of the most significant threats to our present and future. Recently, it has been suggested that antibiotic-resistant microorganisms also exhibit resistance to heavy metals and disinfectants, and these resistance profiles may interact with each other. Microorganisms can be exposed to heavy metals and disinfectants in different ways in various environments. They are especially likely to be exposed to quaternary ammonium compounds used in the food industry or heavy metals due to tap water. Thus, microorganisms can adapt to their environment and gain resistance thanks to horizontal gene transfer. In our research, the heavy metal and disinfectant resistance profiles of 42 isolates whose antibiotic resistance profiles were determined in previous studies revealed the connection between the antibiotic - heavy metal - disinfectant resistances of the isolates. The resistance of the isolates to various heavy metals and disinfectants was determined by determining the minimum inhibition concentrations (MIC) using the broth microdilution method. MIC values obtained from the isolates were compared with those of the control well, and the resistance profiles of the isolates were determined. The isolates used in our research were found to be highly resistant to cobalt (83%), nickel (86%), and triclosan (81%). It has been observed that they are utterly resistant to zinc and lead. Based on the data obtained from the study, it is thought that the high rate of disinfectant and heavy metal resistance may be related to antibiotic resistance. However, more comprehensive studies are needed to understand this relationship fully.
Effects of Coenzyme Q10 on H2O2-Induced Oxidative Stress of Human Keratinocytes
Authors: Suntornnont Nuchanart , Kovavisarach Ammaraluk , Tammachote Rachaneekorn
Published: January 2025

Keratinocytes are particularly vulnerable to oxidative stress due to their function as the primary natural protective barrier exposed to chemicals, rays, and pollution to stimulate the formation of free radicals in the body. Two factors of interest correlate with cellular senescence under oxidative stress. These include regulating antioxidant synthesis, which maintains free-radical homeostasis through the Nrf2 gene, and the prevention of telomere shortening, which involves the collaboration of human telomerase genes, including the hTERT and hTR genes. Coenzyme Q10 (CoQ10) is a wildly used antioxidant in dietary supplements and the cosmetic industry. Therefore, this study aims to investigate the effect of CoQ10 in inhibiting the oxidation process induced by hydrogen peroxide on cell viability, intracellular ROS content, mRNA expression of the Nrf2 gene, hTERT gene, and hTR gene, and relative telomere lengths (RTL). When cells were treated with hydrogen peroxide at LC50 for 24 hours, followed by a 24-hour treatment with 1.00 µM CoQ10, cell viability increased by 16.57 ± 2.25%. Additionally, intracellular ROS content decreased by 37.20 ± 13.22%, Nrf2 gene expression significantly reduced (p < 0.001), and hTERT gene expression significantly increased (p < 0.01). No significant difference in the hTR gene expression and the RTL was detected. In conclusion, this study expands the knowledge of CoQ10 potential as an active ingredient in approaching anti-oxidant and anti-aging treatment.
Implementation of fully automated AI-integrated system for body composition assessment on CT for opportunistic sarcopenia screening: Multicenter prospective study (Preprint)
Authors: Urooj Bushra , Ko Yousun , Na Seongwon , Kim In-One , Lee Eun-Hee , Cho Seon , Jeong Heeryeol , Khang Seungwoo , Lee Jeongjin , Kim Kyung Won
Published: January 2025

BACKGROUND

Opportunistic CT screening for the evaluation of sarcopenia and myosteatosis has been gaining emphasis. A fully automated AI-integrated system for body composition assessment on CT scans is a prerequisite for effective opportunistic screening. However, no study has evaluated the implementation of fully automated AI systems for opportunistic screening in real-world clinical practice for routine health check-ups.

OBJECTIVE

To evaluate the performance and clinical utility of a fully automated AI-integrated system for body composition assessment on opportunistic CT during routine health check-ups.

METHODS

This prospective multicenter study included 537 patients who underwent routine health check-ups across three institutions. Our AI algorithm models are composed of selecting L3 slice and segmenting muscle and fat area in an end-to-end manner. The AI models were integrated into the Picture Archiving and Communication System (PACS) at each institution. Technical success rate, processing time, and segmentation accuracy in Dice similarity coefficient were assessed. Body composition metrics were analyzed across age and sex groups.

RESULTS

The fully automated AI-integrated system successfully retrieved anonymized CT images from the PACS, performed L3 selection and segmentation, and provided body composition metrics, including muscle quality maps and muscle age. The technical success rate was 100% without any failed cases requiring manual adjustment. The mean processing time from CT acquisition to report generation was 4.12 seconds. Segmentation accuracy comparing AI results and human expert results was 97.4%. Significant age-related declines in skeletal muscle area and normal-attenuation muscle area were observed, alongside increases in low-attenuation muscle area and intramuscular adipose tissue.

CONCLUSIONS

Implementation of the fully automated AI-integrated system significantly enhanced opportunistic sarcopenia screening, achieving excellent technical success and high segmentation accuracy without manual intervention. This system has the potential to transform routine health check-ups by providing rapid and accurate assessments of body composition.
Territorial Resources in the Province of Al Hoceima Between Undervaluation and Territorial Development Issues Case: of the Commune Abdelghaya Souahel
Authors: Bouhlal Iliass
Published: January 2025

This study aims to address the problem of the deterioration of territorial resources in light of the spatial dynamics in the Rif Mountains and the resulting constraints that hinder the path of sustainable development, which are mainly linked to natural factors and the accelerating rate of deterioration of land resources, and to human factors such as the intensive exploitation of a narrow and limited area and the increasing reverse migration towards the studied area.Through which we have achieved several results, namely: The study area has various human and natural resources as well as a very important strategic location. Valuing these resources will contribute to achieving sustainable development and revitalizing the local economy. However, these vulnerable resources are subject to intensive exploitation due to their vulnerability and they are not mobilized and valued adequately, which has negative repercussions on the economic and social situation of the population. Added to this is the traditional and irrational exploitation of territorial resources, which leads to an acceleration in the pace of environmental deterioration, such as the uprooting of forests and the spread of kif cultivation. So, what are the territorial resources available in the study area? and to what extent are they capable of achieving sustainable development?
Keywords: Territorial resources - kif culture - Abdelghaya Souahel commune - territorial development.
El recurso indirecto en el contencioso-administrativo español y francés: entre legalidad y seguridad
Authors: Harris Moya Pedro
Published: January 2025

El objetivo de este artículo es comparar cómo los recursos indirectos del derecho administrativo francés y español han articulado los principios de seguridad y legalidad a través del método dogmático. La primera parte de la investigación, analiza la fase de control. Por no condicionar el recurso a la existencia de un reglamento, y adoptar una comprensión amplia de los vicios, se aprecia la prevalencia que el derecho francés le otorga a la legalidad en este ámbito, lo que se invierte en España, a favor de la seguridad, por una concepción más estricta del acto revisado y de sus irregularidades. La segunda parte de este artículo, estudia la sanción aplicable una vez verificada la ilegalidad. Por extender la competencia jurisdiccional para inaplicar los actos impugnados, y consagrar mecanismos para anular los actos inaplicados, se observa la prevalencia de la legalidad en España, lo que se invierte en Francia en pos de la seguridad, por una concepción más estricta de tal competencia y dichas vías anulatorias.
Estas diferencias permiten concluir la existencia de distintas variantes de recursos indirectos, una circunstancia de utilidad a nivel comparado, especialmente en ordenamientos carentes de una interpretación afianzada del ejercicio de estos reclamos.
Aproximación teórica a la tipología de la responsabilidad constitucional
Authors: Uribe Arzate Enrique , Uribe Bustamante Diego Enrique
Published: January 2025

La responsabilidad de los servidores públicos es un tema fundamental para el Estado constitucional; la doctrina y el derecho positivo identifican varios tipos de responsabilidad como son la administrativa, la civil, la penal y la política. Esta última que se tramita como juicio político, ha sido establecida para algunos servidores públicos de la mayor jerarquía, empero no está claro cuáles son las características especiales que determinan qué servidores públicos pueden ser sometidos a este juicio y tampoco cuál es la naturaleza de este mecanismo de control constitucional que concluye con la imposición de sanciones de naturaleza administrativa como son la destitución y la inhabilitación. Por eso creemos que es necesario convertir al juicio político en un juicio de responsabilidad constitucional e incluir las sanciones de naturaleza constitucional correspondientes a este tipo de transgresión que es diferente a la de orden administrativo.
La fuerza de atracción de los regímenes especiales para el manejo de recursos públicos en Colombia: el uso de los poderes legislativos del Ejecutivo para la creación de excepciones al régimen general de contratación estatal
Authors: Barreto Moreno Antonio Alejandro , Celemín Caicedo Yenny Andrea
Published: January 2025

En atención a las necesidades especiales de ciertas entidades públicas, y a la importancia de cumplir requerimientos insatisfechos, el legislador colombiano, a la par de expedir el Estatuto General de Contratación de la Administración Pública, creó algunas excepciones a las reglas de este, mediante el diseño de regímenes especiales. Esta generación de excepciones debería atender a criterios de máxima racionalidad legislativa, e incluso restringir en un solo órgano, y por muy pocas y predefinidas razones, su emisión; y no dejarse, simplemente, al arbitrio de la libertad configurativa del Congreso. Esto, al entender la importancia cardinal que tiene el ejercicio de la función contractual para el cumplimiento de los fines del Estado. De forma adicional, el presidente de la República, en uso de sus facultades de legislador extraordinario y excepcional, ha creado sin mayores exigencias un sinnúmero de regímenes especiales, y ha contribuido por esta vía a difuminar la pretensión de que exista un régimen general de contratación pública, con pocas y limitadas excepciones. En este escrito se analizarán las implicaciones de la creación de regímenes especiales de contratación por parte del presidente de la República, en uso de facultades de legislador extraordinario y excepcional.
Estudio comparado de la legislación cooperativa México-Brasil. Aprendizajes para la armonización del derecho cooperativo latinoamericano
Authors: González Rivera Tatiana Vanessa , Nagao Menezes Daniel Francisco
Published: January 2025

Actualizar y armonizar la legislación cooperativa de la región de América Latina continúa siendo una tarea inconclusa que demanda el sector cooperativo; y aunque hay esfuerzos regionales que han atendido tal exigencia, las nuevas tendencias y necesidades del sector a nivel nacional y regional hacen indispensable retomar estos esfuerzos. Para llevar a cabo tal labor, se requiere un relevamiento de las legislaciones domésticas que, si bien son heterogéneas, a partir del derecho comparado, es posible identificar aspectos comunes y líneas de tendencia que aportan al esfuerzo unificador, sin alterar contexto ni factores endógenos que caracterizan a la economía social y solidaria y en la cual se sitúa la cooperativa como figura asociativa por excelencia. Por lo tanto, este trabajo estudia, a través del método comparado y con aplicación de la técnica documental, la legislación cooperativa en México y Brasil, ambos países con una reconocida trayectoria en materia de cooperativismo. Los resultados obtenidos permiten concluir que hay ciertos elementos jurídicos de ambos ordenamientos que se pueden rescatar a efecto de contemplarlos y reflexionarlos en un esfuerzo armonizador regional; otros más resultan en aprendizajes de lo que debe superarse en legislaciones futuras aplicadas a regular aspectos sustantivos de la sociedad cooperativa.
Who watches the watchmen? Kelsen and Schmitt on the guardian of the Constitution
Authors: Alves da Silva Felipe
Published: January 2025

This article analyses one of the most well-known debates in 20th-century political and legal theory between Carl Schmitt and Hans Kelsen. Although it dates back to the early years of the Weimar Republic, the discussion of the guardian of the constitution focused on the years 1928 and 1931, when the personalistic character of power took place within discussions of constitutional jurisdiction. This article proposes to analyze part of Schmitt’s argument constructed during the 1920s that, to some extent, anticipates the arguments later developed in Der Hüter der Verfassung.
La educación diferenciada por sexo. Derecho a la igualdad y el pluralismo en la educación en España
Authors: Rivas Alberti Jhenny , Espinoza Alexander
Published: January 2025

El pluralismo del modelo educativo que se deriva del artículo 27 de la Constitución Española (CE) —que es, a su vez, una manifestación del pluralismo político que garantiza el artículo 1.1 CE— deja un amplio margen de libertad al legislador para que pueda configurar un modelo educativo en el que quepan opciones pedagógicas de muy diversa índole, con la única exigencia de que no sean contrarias a los derechos constitucionalmente consagrados. Se analiza la conformidad de la educación diferenciada por sexo con el derecho a la igualdad. La escuela diferenciada y la escuela mixta deben promover el desarrollo de todos los aspectos propios de la personalidad y excluir cualquier tipo de aprendizaje que perpetúe la asignación tradicional de roles en la sociedad.
La defensa de derechos colectivos con las obligaciones erga omnes en el derecho internacional: un nuevo paradigma de responsabilidad internacional
Authors: Olvera Amado José María
Published: January 2025

A partir de la sentencia de la Corte Internacional de Justicia en el caso Barcelona Traction, se introdujo al derecho internacional el concepto de obligaciones erga omnes. A pesar de las similitudes con la actio popularis, estas figuras procesales difieren fundamentalmente. No obstante, ambas buscan el mismo fin: hacer exigibles los derechos que corresponden a una colectividad. Es a través de la figura de erga omnes partes que emerge la posibilidad de proteger los valores compartidos de la comunidad internacional. En este sentido, no sólo es evidente la necesidad de esta clase de obligaciones, sino que su concepción modifica el paradigma a nivel internacional, respecto a la perspectiva tradicional de responsabilidad bilateral entre los estados. En este artículo, se realiza un análisis sobre las obligaciones erga omnes.
Políticas públicas y acceso a la vivienda en Argentina durante el gobierno de Cambiemos (2015-2019)
Authors: Cristeche Mauro , Vértiz Francisco , Aguirre Macarena Yasmín
Published: January 2025

El acceso a la vivienda está atravesado por una serie de problemas socioeconómicos que afectan a la sociedad argentina desde hace décadas. Las políticas públicas pueden tender a mitigar o remover los obstáculos para el acceso, pero también a profundizarlos y/o multiplicarlos. Este trabajo propone un acercamiento a las principales políticas de vivienda en Argentina durante el gobierno de Cambiemos y algunas lecturas críticas sobre su impacto en la satisfacción del derecho. A partir de un análisis multidimensional de aspectos teóricos, jurídicos, económicos y de políticas públicas, explora el contexto socioeconómico y político, algunas políticas macroeconómicas con impacto específico, los programas públicos de construcción de viviendas y de urbanización de villas de emergencias, el mercado de créditos hipotecarios, y la situación de los alquileres. Del análisis surge que, más allá de algunas medidas positivas, como el lanzamiento del RENABAP y el sistema de créditos hipotecarios UVA, no ha habido avances considerables en la resolución del problema de la vivienda. Las políticas específicas del área fueron insuficientes y el programa general de gobierno provocó un retroceso significativo de las condiciones materiales de la clase trabajadora, lo que se tradujo en mayores obstáculos para lograr la satisfacción de este derecho fundamental.
La conciliación como herramienta de acceso a la justicia social, conforme a la reforma laboral 2019 en México
Authors: López Pérez Moisés David , Gorjón Gómez Gabriel de Jesús , Tórrez Tórrez Mario Isaías
Published: January 2025

En este artículo se realiza un trabajo investigativo para conocer la efectividad de la reforma laboral de 2019, respecto a la conciliación laboral como herramienta de acceso a la justicia en México, tomando en consideración los conflictos individuales suscitados entre patrones y trabajadores. La metodología se basa en un estudio cuantitativo, la técnica es la encuesta bajo la escala Likert. Los datos se procesaron a través del SPSS. El objetivo de la investigación es demostrar los elementos principales que influyen en la efectividad de la reforma, respecto a la conciliación como acceso a la justicia social. Se presenta una aproximación de la importancia de la conciliación prejudicial, con el cual se pretende incentivar el estudio en otros Estados del país, para conocer cómo se está desarrollando el procedimiento tomando en consideración la apreciación de los sujetos conflictuados. Por factores de tiempo y recursos, la investigación se centró en Monterrey, Estado de Nuevo León, sin embargo, esta nos brinda resultados representativos por ser una de las ciudades económicas más importante de México. Los resultados encontrados son significativos y nos dan un panorama positivo de los logros que se están alcanzando con la reforma.
Diálogos interculturales y cosmovisiones indígenas en su relación con el agua en Colombia
Authors: Ortega Guzmán Luis Fernando , Tirado Acero Misael , Rey-Guerrero Diego Fernando
Published: January 2025

Este artículo explora las relaciones entre las cosmovisiones indígenas sobre el agua y su impacto en la organización social y territorial en Colombia, destacando la importancia de un diálogo intercultural para la sostenibilidad del agua. Se revela cómo el agua, más allá de ser un recurso natural, es considerada un ente sagrado y central en las prácticas culturales y espirituales. Los hallazgos subrayan la profunda interconexión entre las concepciones del agua y la estructura social y territorial, mostrando que las prácticas de gestión del agua son sostenibles y están intrínsecamente ligadas al mundo material y espiritual del sistema de conocimiento indígena. El estudio concluye resaltando la necesidad de integrar estas perspectivas en las políticas de gestión del agua para promover prácticas más sostenibles y justas, enfatizando el valor del conocimiento indígena en la conservación del agua.
Descolonización de los derechos de los pueblos originarios en México: ¿hacia dónde vamos?
Authors: León Ortiz Miguel Ángel
Published: January 2025

La colonización ibérica de los pueblos autóctonos de la antigua Mesoamérica trajo consigo la imposición del régimen monocultural eurocéntrico de los conquistadores, que borró casi por completo los órdenes normativos, basados en usos y costumbres, de las poblaciones que residían en los territorios descubiertos, apelando a las ideas de progreso, civilidad, cohesión y orden social. Al consumarse la Independencia de México, esta situación no cambió mucho, por lo que, los intereses y necesidades de las comunidades indígenas, no se consideraron dentro de la organización política de los territorios colonizados. Fue hasta hace no mucho que los estudios críticos del derecho, plantearon la descolonización de los sistemas jurídicos de América Latina como hito para reconocer los derechos de los pueblos y comunidades indígenas de la región, valiéndose de las premisas de nuevos constitucionalismos, cimentados en epistemologías emancipadoras de los derechos de estas poblaciones, que surgieron en los albores del siglo XXI. En este trabajo, se exploran las bases que dieron lugar a estos últimos, y se analiza si es posible materializarlas en México para conseguir el respeto, reconocimiento, protección y garantía de los derechos de estos pueblos en los próximos años.
Healthcare System using AI and Machine Learning
Authors: Nagar Harsh
Published: January 2025

Artificial Intelligence (AI) and Machine Learning (ML) are at the forefront of healthcare in scaling innovations in
healthcare & medicine as the technology is expanding – helping in screening of large populations for diseases, diagnosis,
treatment, and preventive services at individual level. This paper provides a review on the state of several AI technologies in the
health domain and its usage in the different areas such as diagnostic and real-time health monitoring and decision support
systems. Wearable devices come with compelling artefacts that can improve the accuracy of AI based models like CNN and
Random Forest however it shows difficulties with respect to data privacy, scalability and explainability. It gives a broad-scope
view on potential research challenges, as well as challenges and barriers, regarding the regulation of AI within current
healthcare systems, paving the way for more effective, more accessible and even more equitable solutions.
Reseña: Productive Fandom. Intermediality and Affective Reception in Fan Cultures
Authors: Huerta Miranda Ayla
Published: January 2025

Antes de nuestro encuentro ya había leído su libro Productive Fandom. Intermediality and Affective Reception in Fan Cultures, debido a ello se creó en mí la impresión de que se trataba de una persona involucrada con fandoms de productos culturales muy variados, este libro es la prueba. Después de nuestra conversación en un café cercano a la estación central de Utrecht y de presenciar cara a cara el entusiasmo con el que mi interlocutora se expresaba de los textos objeto de su fanatismo entendí por qué las relaciones afectivas que los fans establecen con productos de la cultura pop es un tema central en su libro.
Tendências na prescrição do ensino da avaliação: uma análise comparativa nos cursos de formação de professores de educação física em sete países Latino-Americanos
Authors: Paula Sayonara Cunha de , Stieg Ronildo , Ferreira Neto Amarílio , Dos Santos Wagner
Published: January 2025

Este artigo tem como objetivo analisar e comparar quais disciplinas prescrevem o ensino da avaliação e quais são as características dessas prescrições nos cursos de formação de professores de Educação Física em sete países da América Latina. Caracteriza-se como uma pesquisa qualitativa documental, fundamentada no método comparado e que utiliza o software Iramuteq como ferramenta de auxílio para organização dos dados. As fontes são compostas por 183 planos de disciplinas de 16 cursos de Educação Física. Os resultados indicaram duas categorias: a) disciplinas que prescrevem o ensino da avaliação; e b) a prescrição da avaliação enquanto teorização, materialização e/ou estabelecendo o par dialético teoria e prática. Conclui-se que a integração teorização-materialização é essencial para a formação e preparação de professores para os desafios prática docente com a avaliação educacional.
Abundance of Hudsonian Godwits (Limosa haemastica) and Whimbrels (Numenius phaeopus) in two marine wetlands on Quinchao Island, Chiloé, southern Chile
Authors: Delgado Claudio , Cursach Valenzuela Jaime , Espinoza Luis , Pfeifer Ana , Rau Jaime
Published: January 2025

This study focuses on the abundance of Hudsonian Godwits (Limosa haemastica) and Whimbrels (Numenius phaeopus) in two marine wetlands on Quinchao Island, in the Chiloé Archipelago, southern Chile. Over a ten-year period (2010-2020), seasonal counts were conducted in the wetlands of Curaco de Vélez and Chullec. The results indicate fluctuations in the abundance of both species, with significant seasonal differences, especially between winter and summer. Annual median abundances for Hudsonian Godwits were 2450 individuals in Curaco de Vélez and 3450 in Chullec, while for Whimbrels they were 79.5 and 72.5 individuals respectively. The data suggest that both wetlands are important wintering sites for the conservation of this birds. The study highlights the importance of protecting the Chullec marine wetland, currently without legal protection, similar to Curaco de Vélez as a Nature Sanctuary, for effective and integrated conservation of these migratory species
Predation of sea turtles (Chelonia mydas) by southern sea lions (Otaria byronia) and its relationship with overfishing in northern Chile
Authors: Contreras D. , Sielfeld Walter , Salinas P. , Berrios R. , Rivera T. , Astudillo M. , Pizarro K.
Published: January 2025

The disruption of a new food chain in the South American sea lion (SSL, Otaria byronia), with predation on green sea turtles (GST, Chelonia mydas) is reported for Northern Chile, probably from “nutritional stress” as result of anchovy (Engraulis ringens) overfishing, its fundamental food, with implications that cross multinational barriers in the South Pacific due to the shared nature of the resource. From 2011 an increase in carcasses of GST turtles with damages attributable to attacks by larger predators was observed on beaches of Arica (18°28´S), for which a necropsy study for signs attributable to predation, was carried out between November 2013 and May 2019. Jointly, direct observations of SSL attacks were made between Arica (18°28´S) and Iquique (20°13´S), that document predation of GST by SSL. 195 strandings including 179 Chelonia mydas, 15 Lepidochelys olivacea y 1 Eretmochelys imbricatea were recorded. 96.01% were strandings, 2.23% concentrated in drift, 1.12% as ghost fishing and 0.56% by fishermen from a gillnet.

The necropsies of 14 carcasses in stage 1 and 2, showed damage attributable to interaction (alive or dead) with predators and/or scavengers. Most part of the observed injuries (tears of breakage and detachment of skin, muscles, internal structures such as the trachea, esophagus, stomach and part of the intestines, heart and liver) were attributable to SSL attacks and agree with the direct observations. Attacks by sharks or killer whales, and death by immersion or health problems could not be confirmed.

The effect of this new feeding strategy of the SSL casts a shadow of uncertainty about the success of the green sea turtle population recovery program of northern Chile started in 2012. The results also suggest the need for evaluation of anchovy management programs and standards and the incorporation of an ecosystem approach to management plans, including the trophic needs of top depredators of the system.
Optimization of the production of sodium alginate derivatives
Authors:   University of Latvia, Institute of Biology, Vasiļjeva Svetlana , Krumiņš Roberts , Smirnova Gaļina , Basova Natālija , Mirshafiey Abbas , Partsvania Hamlet , Babarykin Dmitry ,   Faculty of Biology, University of Latvia,   Institute of Innovative Biomedical Technology Ltd,   Italian Multiple Sclerosis Society Foundation (FISM)
Published: January 2025

A natural polysaccharide sodium alginate, a salt of alginic acid, is widely used as a wetting and thickening agent in food, pharmaceuticals, cosmetics and other fields. Interest in the practical use of the derivatives of sodium alginate poses the problem of their convenient and cost-effective production.
Two methods applied for the synthesis of uronic acids from sodium alginate were studied. The previously created method of Prof. A. Mirshafiey (Mirshafiey & Lalander, 2024) has been tested in the laboratory. The method is based on the hydrolysis of sodium alginate with sulfuric acid followed by the separation of D-mannuronic acid (MA) and L-guluronic acid (GA), that included pH regulation and precipitation by centrifugation and quite long-time drying process. However, the method is rather complex, time-consuming and energy-intensive. To simplify and reduce the cost of uronic acids production, it was necessary to optimize the technology. Optimized in the laboratory method kept the previous step of sodium alginate hydrolysis unchanged. Further, the method differed in that the MA and GA mixture was precipitated, washed and filtered on membrane filter without prior separation. The obtained MA + GA gel composition may be used without drying in the creation of new innovative products for human health. The optimization of the method has greatly simplified the synthesis of sodium alginate derivatives and makes it possible to increase the economic efficiency of the process.
Gamma Secretase Inhibitors in Cancer
Authors: Aruna Dr. V. , Jha Dr. Anand Mohan , A Fatima Dr Riffat , Prasada Kumar Mahapatra Dr. Abikesh
Published: January 2025

Gamma secretase inhibitors (GSIs), for Alzheimer's disease treatment, have been repurposed as anticancer agents because they inhibit receptor cleavage. Preclinical studies suggested that GSIs effectively promote the differentiation and apoptosis of cancer stem-like cells while obstructing epithelial-to-mesenchymal transition and increasing sensitivity to conventional chemotherapy and radiotherapies. However, their clinical application remains limited, as GSIs have shown minimal efficacy in the majority of solid tumors, with significant exceptions including central nervous system malignancies and desmoid tumors. It highlights several unresolved questions, including their overall impact on anticancer immune responses and whether targeting tumor-intrinsic compensatory pathways would be necessary for achieving optimal results. Advancing our understanding of GSI mechanisms is critical for effectively integrating these inhibitors into combination therapies and addressing Notch-dependent cancers. This review aims to provide a comprehensive overview of GSI mechanisms, analyze their clinical effects thus far, and propose future research directions. It emphasizes the importance of evaluating GSIs' effects on immune responses in cancer patients and overcoming tumor-intrinsic resistance to unlock their full therapeutic potential, paving the way for more effective combinatorial strategies in oncology.
Targeting Angiogenesis: New Horizons in Ocular Tumor Therapy
Authors: A. Razzak Mahmood Prof Dr. Ammar , Mohan Jha Dr. Anand , Abraham Dr. John , Elizabeth Devi Dr. Laishram
Published: January 2025

Angiogenesis, the formation of new blood vessels within malignant tumors, is essential for cancer growth, sustenance, and metastasis. This complex process is regulated by a variety of molecular factors and pathways, as explored in a recent comprehensive review on angiogenesis. The review highlights the regulatory mechanisms that unlock therapeutic potential, focusing on hypoxia and its role in inducing vascular endothelial growth factor (VEGF) expression, a key driver of angiogenesis. It examines the interplay between angiopoietins, fibroblast growth factors (FGFs), and endogenous inhibitors of angiogenesis, as well as the role of transmembrane adhesion proteins, such as integrins, in mediating cellular responses critical to vascular development. The review also discusses the critical role of angiogenesis in tumor growth, emphasizing how the "angiogenic switch" enables tumors to acquire an aggressive phenotype. In this context, anti-angiogenic (AAG) therapies targeting these pathways are being investigated for various cancers, including ocular malignancies. Despite the widespread use of angiogenesis inhibitors in non-malignant ocular diseases, reports of their application in ocular tumors remain limited. Evidence supports the involvement of angiogenesis in the progression and metastasis of ocular malignancies, including retinoblastoma, ocular melanoma, and Von Hippel-Lindau (VHL) disease. Preliminary studies of AAG therapies for ocular tumors, such as ocular melanoma and VHL, show promising results. However, their efficacy needs to be confirmed through well-designed, controlled clinical trials. By providing a detailed overview of the molecular underpinnings of angiogenesis and its implications for tumor growth, this review underscores the potential of targeting angiogenic pathways as a therapeutic strategy for ocular tumors and other malignancies.
Detection of Bone Metastasis On Whole Body Bone Scan Among Sudanese Patients with Proven Cancer in Tumours Therapy and Cancer Research Center –Shendi –Sudan
Authors: Awad Elkareim Imam Dr. Motwakil Imam , Mohammed Taha Taha Ali , Abdalla Abukleawa Abdalla Atta , Hassan Mohammed Mahmoud Babekir
Published: January 2025

Bony metastasis is one of the most common causes of death in patients with proven cancer, most of the patients present by pathological fracture, and carry poor prognosis. The bone scan is the main investigation for diagnosis. Our objective is to determine the most common cancer that causes metastasis, the commonest site involved in the skeleton, and the metastatic pattern for each cancer. We studied 150 cases collected in tumor therapy and cancer research centers, those who underwent bone scans using a gamma camera. The most age of our patients ranged between (40 and 60) years old. The predominance of females was noticed (68.7%). 90% of the patients were married. The study showed that 35.3% with left breast cancer, 20% with right breast cancer, and 22% with prostate cancer. The study showed that 40% of the participants had bone metastasis, 41.7% with prostate cancer, 21.7% with left breast cancer, and 16.7% with right breast cancer. The study showed that the lumber vertebra involved in 51.7% of bone metastasis, thoracic vertebra involved in (50%) with bone metastasis, the anterior ribs involved in 28.3% with bone metastasis, while posterior ribs in 25%, the right femur involved in 28.3 while the left femur engaged in 25% of bone metastasis and 25% metastasis to the skull. About 40% of the patients had bony metastasis. Breast and prostate are the most common cancers that cause bony metastasis. The spine is the most common site for metastasis. Prostate cancer metastasized mainly to the spine followed by the femur, ribs, skull, and shoulders
Examining Piperine's Potential for Cancer Chemoprevention
Authors: Sheetal Asutkar Prof Dr , Lakshmi E. , Singh Chhabra Dr. Gurmeet
Published: January 2025

Cancer is a major global health issue that raises morbidity and death rates everywhere. It is distinguished by the unchecked growth, survival, and dissemination of cancerous cells. Complex genetic, molecular, and metabolic changes that facilitate the conversion of healthy cells to malignant cells characterize the multi-stage process of cancer formation. Cancer chemoprevention, which uses pharmaceutically active drugs to stop, slow, postpone, or reverse the progression of cancer at various stages, is one of the innovative ways needed to treat this complex illness. Black pepper (Piper nigrum) contains piperine, a naturally occurring alkaloid that has garnered a lot of attention due to its several therapeutic applications, which include immunomodulatory, antibacterial, anti-inflammatory, and antioxidant properties. Piperine can inhibit important signaling pathways and molecular processes associated with carcinogenesis, including inflammation, oxidative stress, and the control of apoptosis. These processes are all essential for the development, progression, and spread of cancer. It has been demonstrated that piperine dramatically modulates many pathways, such as MAPK, PI3K/Akt, STAT3, and NF-κB, which are frequently dysregulated in various cancer types. Piperine has shown promise in enhancing the therapeutic effectiveness of traditional cancer treatments by increasing the sensitivity of cancer cells to UV phototherapy and TRAIL-based treatments and reducing resistance. Synergistic effects with chemotherapeutic medications may result in combination therapy that improves clinical results. This review assesses the potential effects, and long-term safety of drugs based on piperine, highlighting the urgent need for comprehensive preclinical and clinical research to confirm the drugs' safety profile and therapeutic efficacy.
Targeting PIN1 enzyme for pancreatic cancer
Authors: Subramaniam Aswinprakash , Selvaraj Vinoth Kumar , Dhamodharan Jagadeesh , Gurumoorthy Ragesh
Published: January 2025

Hepatocellular carcinoma (HCC) is a major global health concern, ranking as the fourth most common cancer in men and eighth in women, with an alarming mortality rate. Despite advances in medical interventions, including surgical resection, liver transplantation, and molecular-targeted therapies like sorafenib and lenvatinib, outcomes for advanced HCC remain suboptimal. Protein phosphorylation and isomerization have emerged as critical regulators of cancer progression, with the peptidyl-prolyl cis-trans isomerase PIN1 playing a significant role in hepatocarcinogenesis. PIN1 is implicated in the stability and activity of key oncogenic and tumor suppressor proteins, driving uncontrolled cell proliferation and tumor growth in HCC. This review explores the molecular mechanisms by which PIN1 facilitates HCC progression, focusing on its interaction with cyclin D1 and its role in oncogenic signaling pathways. The research also highlights the potential of targeting PIN1 as a therapeutic strategy. Preclinical studies showed that PIN1 inhibition reduces tumor growth, induces cell death, and enhances survival in animal models. Moreover, PIN1 inhibitors like API-1, ATRA, and ATO have demonstrated promising anti-proliferative effects on HCC cells, paving the way for novel treatment avenues. Given the resistance challenges to current therapies like sorafenib, combining PIN1 inhibitors with existing drugs may offer enhanced efficacy and mitigate resistance. Further research is essential to understand PIN1-mediated pathways in drug resistance and to optimize PIN1-targeted therapies for clinical use. This review underscores the therapeutic potential of PIN1 inhibition in improving outcomes for HCC patients.
Sustainability Disclosure, Institutional Ownership and Value of Listed Companies in Nigeria
Authors: ORSHI TERYIMA SAMUEL , YUSUF MOHAMMED ALIYU
Published: January 2025

Research aim: This study seeks to examine the relationship between sustainability
disclosure and the value of listed companies in Nigeria, using institutional ownership as
a moderator.
Design/ Methodology/ Approach: Data was collected from annual reports and accounts of
the firms and daily price listings of the Nigerian Exchange Group from 2014 to 2021. The
study uses the Feltham and Ohlson (1995) linear information valuation model to estimate
industry-based influence on firm value variations.
Research finding: The results show that economic and environmental disclosures as well
as institutional ownership significantly and positively impact the value of listed firms,
while social disclosure has an insignificant effect. Institutional ownership enhances the
positive effect of economic disclosure, but does not enhance the effect of environmental
disclosure on firm value, and there is no statistical evidence that it affects the impact of
social disclosure on firms’ value.
Theoretical contribution/Originality: The study uses stakeholder and legitimacy theories
to guide decision-making in sustainability disclosure and institutional ownership. It
suggests that greater transparency and accountability in sustainability reporting in Nigeria
are needed.
Practitioner/Policy implication: The study findings support regulators to mandate
sustainability disclosure, raise awareness about its benefits and impact on value, and
encourage investor participation in corporate sustainability decision-making. This would
enhance the value creation and governance process, ultimately leading to better governance
and increased firm value.
Research limitation: This study focuses only on sustainability disclosure of Nigerian
companies in selected sectors of the economy. Future studies can explore the long-term
effects of sustainability disclosures on firm value to understand whether social disclosures
yield delayed financial benefits, investigate the impact of sustainability disclosures on firm
value across different sectors in Nigeria, and explore how governance frameworks influence
the quality of sustainability disclosures and their subsequent effect on firm value.
التحليل الإيديولوجي والمنهجي عن الحفريات الإسرائيلية في القدس والمسجد الأقصى المبارك Ideological and Methodological Analysis on Israeli Excavations in Islamicjerusalem and al-Aqsa Mosque
Authors: Amro Arafat Mohammad , (Corresponding Author) Aminurraasyid Yatiban
Published: January 2025

This study aims to analyse alternative cultural awareness among nations, understanding the intellectual invasion strategies and accompanying colonial normalization policies. This research employed a critical and analytical approach, comparing information gathered from previous literature, institutional documents, Jerusalem archaeological institutes, and daily observations stemming from a long-standing work in the city. It utilized scientific and unbiased analytical methods, particularly in conflict settings, drawing on the settler colonial theory and the Copenhagen School of Security Studies. The study found that these excavations, from their inception, have been ideologically driven with a biblical settler agenda as their primary methodology in dealing with archaeological evidence and Arab historical records on this land. The main objective is to entrench biblical narratives as historical realities, even though falsification and distortion, including erasing and Judaizing all evidence contradicting Jewish beliefs. This serves the broader aim of entrenching the colonial Zionist entity in Palestine and fulfilling the so-called biblical concept of "Greater Israel" in the heart of the Arab world.
Física, Ambiente y Educación Ambiental; Percepciones desde los docentes de Ciencias Naturales en formación
Authors: Valderrama Daniel Alejandro , Garzón Velasco Marlon Damian , Alfonso Chaparro Lina Paola
Published: January 2025

La Educación Ambiental (EA) es vital para formar ciudadanos que entiendan y valoren la sustentabilidad con alternativa epistemológica y practica que mitiga las problemáticas ambientales actuales. Esta investigación surge a partir de la problematización de la relación entre la EA y las ciencias físicas, integraciones que frecuentemente se pasa por alto en los currículos y en los procesos de enseñanza de esta ciencia y de la EA. Es crucial resaltar que la física brinda marcos conceptuales y herramientas metodológicas que pueden profundizar la comprensión de fenómenos ambientales desde una óptica amplia y multidimensional. Para explorar estas relaciones, se llevó a cabo una investigación con un matiz hermenéutico interpretativo. A través de un cuestionario, se recogieron las percepciones de los futuros docentes en el área de ciencias naturales sobre el tema. Los hallazgos revelaron que una considerable cantidad de ellos reconoce y valora la correlación entre la física y la EA. Desde su punto de vista, esta unión es fundamental no solo para tener una visión integral de las dinámicas ambientales, sino también para fomentar en los estudiantes un pensamiento crítico, articulado y fundamentado frente al equilibrio ambiental. La investigación también destacó las oportunidades didácticas que se presentan al entrelazar la física con la EA. Al relacionar conceptos físicos con problemáticas ambientales reales, se puede reforzar el aprendizaje, haciéndolo significativo y perdurable en el tiempo. Esta fusión interdisciplinaria también tiene el potencial de incrementar la motivación e interés de los estudiantes, impulsando una actitud más activa y comprometida en su proceso educativo.
El cine foro como modelo didáctico para mejorar los procesos lectores en estudiantes de secundaria: un modelo de investigación acción participativa
Authors: Vides Argel Karina Paola , Montes Miranda Alexander Javier
Published: January 2025

El presente artículo detalla los resultados de una investigación realizada en la Institución Educativa San José CIP, Sincelejo, Sucre, con el objetivo de fortalecer el hábito lector entre los estudiantes de grado once mediante la técnica del cine foro. La investigación, de enfoque cualitativo empleó un modelo de investigación acción participativa, utilizó entrevistas estructuradas y observación directa para recolectar datos sobre el comportamiento lector de los estudiantes. Los hallazgos revelaron la falta de estímulo hacia la lectura desde temprana edad tanto en el entorno familiar como en la escuela, y destacaron limitaciones en las habilidades de expresión oral, argumentación y pensamiento crítico, así como una tendencia generalizada a la falta de interés o motivación para interactuar con un libro. Estos factores se consideran negativos para el desarrollo adecuado de las habilidades comunicativas de los estudiantes y para alcanzar un rendimiento académico óptimo en el nivel superior.