Abstract P5-13-18: Barriers to adjuvant radiotherapy treatment for breast cancer in a teaching hospital in Brazil
Authors: Vieira CM , Nogueira-Rodrigues A , Sousa CF , Krush L , Goss PE 
Published: May 2019

BACKGROUND: Adjuvant treatment of non-metastatic breast cancer (BC) represents an important paradigm of multimodality approach in oncology practice, with an established role for radiotherapy (RT). A delay of adjuvant radiotherapy can lead to poorer results. When chemotherapy (CT) is not indicated, RT should be initiated within 8 weeks after surgery. If CT is administered first, RT should be started within 7 months from surgery, since there is a continuous relation between time to radiotherapy and local recurrence. Brazil's public healthcare system, SUS, faces many challenges caring for cancer patients: inadequate funding, inequitable distribution of resources and services, among others. According to research done by Lins et al, around 458 linear accelerators would be necessary to supply the Brazilian public health demand and end the waiting line for radiation therapy. Currently, our healthcare system has 283 machines, which are responsible for more than 70% of our population. Furthermore, patients lack understanding of treatment windows, which is an additional hurdle.

METHODS: We randomly selected 122 charts of female BC patients submitted to treatment with curative intent from 2003-2017 in Hospital das Clínicas da UFMG, the biggest teaching hospital of the 3rd largest city in Brazil. Primary endpoint was to determine median time from surgery to adjuvant radiotherapy, and second point was to determine median radiotherapy time.

RESULTS: Twenty eight patients were not included in the analysis, 26 due to lack of information in the charts and two for not having received the proposed radiotherapy. Ninety four patients were included: median age was 49 years old (21-90), 21.5% were stage I, 41.9% stage II and 34.4% stage III at diagnosis. Patients received chemotherapy (neo or adjuvant), hormonotherapy, or both, according to oncologists discretion. All patients were submitted to surgery and radiotherapy. Long median times from referral to RT initiation and to radiotherapy completion were identified: 54 days and 97 days, respectively, as well as 7 months from surgery to beginning of RT (1-16) and 9 months from diagnosis to its completion (2-29).Biopsies were performed in 27 different sites and RT in 12.

IntervalMedian Time (days)Biopsy to results13 (1-77)Referral to RT initiation54 (1-238)Referral to RT completion97 (43-238)RT initiation to RT completion42 (20-80)

IntervalMedian Time (months)Surgery to RT initiation7 (1-16)Diagnosis to RT completion9 (2-29)

CONCLUSIONS: This study shows that intervals for completion of adjuvant radiotherapy are well above recommended, mostly due to long delays in initiating radiotherapy. Although in our study all patients were conducted by the same oncology team, the system is fragmented, making it even more difficult for patients to receive multidisciplinary care and improve prognosis. There is undeniable need for more radiotherapy machines, but since their acquisition depends on costly governmental actions, we need to think about strategies that may allow us to better use the resources already available. We believe that Patient Navigation plays an important role here and were are establishing this program in our institution with Global Cancer Institute support.

Citation Format: Vieira CM, Nogueira-Rodrigues A, Sousa CF, Krush L, Goss PE. Barriers to adjuvant radiotherapy treatment for breast cancer in a teaching hospital in Brazil [abstract]. In: Proceedings of the 2018 San Antonio Breast Cancer Symposium; 2018 Dec 4-8; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2019;79(4 Suppl):Abstract nr P5-13-18.