bluuebunny/crossref_metadata_2025 huggingface dataset:
Giovanni Kreglianovich’s Orazio: An Exemplum of the Process of Rewriting
Authors: Granata Joanne
Published: January 2021

Rewriting and reinvention of previously told stories and recognizable themes build upon an established literary canon, creating new connections amongst texts, while creating increasingly hypertextual works. This article explores the nature of rewriting, the reinvention of previously existing themes within literature, and the dialectic between past, present, and future embodied within this process. The specific focus of this study is the Dalmatian author Giovanni Kreglianovich, who, with his tragedy Orazio (1797) rewrites and adapts the ancient Roman legend of the battle between the Curiatii and the Horatii to reflect the political, social, and literary changes of the late 1800s in Europe. Primary sources such as Livy’s Ab urbe condita, Aretino’s Orazia (1546), and Pierre Corneille’s Horace (1640) are compared to and contrasted with Kreglianovich’s Orazio in order to highlight the differences between these works and to bring to the fore how and why the source material was rewritten. Utilized as a vehicle to espouse contemporary concerns, Kreglianovich employed aspects of antiquity and transformed them into a means through which social and political issues pertinent to the time could be revealed. In reusing one of the most famous identity myths of ancient Rome, Kreglianovich was able to create a unique tragedy that partakes in the literary phenomenon of rewriting, while promoting patriotism, as well as a sense of identity and belonging in his fellow Dalmatian compatriots.
Food Consumption in Ferzan Ozpetek’s Hamam and Luca Guadagnino’s Io sono l’amore: A Gender Issue
Authors: Sambuco Patrizia
Published: January 2021

Within the wide range of scholarly works on food studies, the topic of food and cinema has gained increasing attention in recent years. This article contributes to the discussion offering a gender per­spective in the analysis of Italian films. It examines cinematic represen­tations of food consumption in Ferzan Ozpetek’s Hamam and Luca Guadagnino’s Io sono l’amore. Food consumption is a means of look­ing at self-identity and the relationship of the individual to the outside world. Eating implies taking part of the outside world inside, and as such it involves not only nutrition for the body but invests the sub­ject with cultural meanings. As a result, the analysis of food consump­tion lends itself to an examination of cultural gender dynamics that influence representations. Through a gender reading of specific scenes, the article argues that in spite of the apparent representations of inde­pendent, successful female protagonists who dare to challenge social conventions, the films considered contribute to the reinforcement of traditional gender constructions. Claude Fischler’s and Pasi Falk’s theo­ries of food consumption help to uncover how the sensory and aesthetic dimensions prevail in the representations of the women protagonists of the films analysed. The female protagonists’ relationship to the outside world remains an individual one, experienced at the sensory level, that cannot express the radical and collective transformations available to the male protagonists.
(Un)Human Relations: Transhumanism in Francesco Verso’s Nexhuman
Authors: Vizmuller-Zocco Jana
Published: January 2021

Transhumanism is an international movement which es­pouses the idea that any human organ, function, sense, ability, can be augmented and ameliorated with the judicious use of technology. The ethical, cultural, social, biological, economic implications for this view are far-reaching and point to a number of complex ques­tions whose solution eludes researchers so far. One of the possible sources for answers to these is found in science fiction. While trans­humanism is a relatively recent phenomenon (last 25 years or so), science fiction published in English that mirrors some of its issues and ideas has been flourishing for at least as long. In Italy, science fiction is starting to enjoy popularity and critical depth in no small measure due to the untiring abilities of a number of authors. This article analyzes the intersections between human and machine as they are portrayed in Francesco Verso’s Nexhuman. Francesco Verso has published 4 award-winning science fiction novels and a number of short stories. Nexhuman offers a considerable narrative construct which paints a dystopian future where trash is formed and re-formed, sold and reworked; however, strong emotions are not absent, since love may flourish in this “kipple”-laden setting, as well as violence and obsession. Transhumanist ideas explicitly dealt with in the novel include the end of death, the question of the soul, mind uploading, limb prosthesis, the co-existence of humans with mind-uploaded be­ings. The amalgam between human and machine does away with the Self and the Other(s) as separate entities and constructs a completely different Weltanschauung. Nexhuman is not only a transhumanist trailblazer within the flourishing arena of Italian science fiction, but also a springboard for deeper understanding of what makes us human and the extent to which binary categories need to be overcome in order to create a more accommodating world.
Nuovomondo, Ellis Island, and Italian Immigrants: A New Appraisal by Emanuele Crialese
Authors: Michaud Marie-Christine
Published: January 2021

Ellis Island remains in the American collective consciousness a centre of immigration where thousands of Europeans who expected to enter the United States between 1892 and 1954, went through. As such, Ellis Island was a symbolic bridge between the Old World and the New. It is the vision of this bridge, or rather a no man’s land between the two worlds that Emanuele Crialese wants to give of Ellis Island in his movie Nuovomondo (Golden Door in the international version). It deals with the journey to America of a Sicilian family at the beginning of the 20th century. It is divided into three parts, one in Sicily dealing with the departure; the second one is the journey on the ship; the third one extensively deals with the arrival on Ellis Island. The film is rather realistic in the sense that it is widely based upon archival material, which becomes apparent when comparing photographs taken at the turn of the century and the scenes from the movie taking place in Ellis Island. By being realistic Crialese first associates Ellis Island to an alienating island, a devilish place where immigrants experienced trauma and humiliation, even possible deportation. The study of the staging reveals that the place is often seen as a prison and that it is linked to confusion and misunderstanding between the immigrants, their dreams and the requirements of the American immigration officers. Nevertheless, the movie is optimistic and displays a hopeful image of Ellis Island. The main characters manage to be admitted in America then seen as a Promised Land. But, the United States is never presented in the film, which provides a feeling of unreachability, as if Emanuele Crialese had wanted to challenge the myth of “il Nuovomondo” as a Promised Land.
Mutiny in the House: Domestic Rebellion in Fausta Cialente’s Natalia
Authors: Salsini Laura A.
Published: January 2021

The cult of domesticity positions women into a state of subservience while reinforcing gendered roles. The ideology was propagated in post-Unification Italy by Catholic doctrine as well as Fascist propaganda and practices that consigned women to the roles of wives and mothers. The physical site of the cult of domesticity was the home where traditional values were honored and upheld. In Fausta Cialente’s novel Natalia—originally published in 1930 and censored by the Fascist regime, then reissued in 1982—the home becomes a site of rebellion and resistance, which challenges ideology that limits female autonomy. In Natalia, a verdant house in the country is the scene of illicit sexual activity between the female protagonist and a young woman, and an ancestral home becomes the threatening locus of the protagonist’s marriage, as well as the setting of her failed attempt at motherhood. Throughout the text, the explicit connection between physical space—the home—and female autonomy, acts as a critique of female oppression and pervasive societal expectations.
Evolução clí­nica e social da hansení­ase em Pernambuco: um estudo etnobibliográfico
Authors: Silva Fernanda da Mata Vasconcelos , De Andrade Angela Roberta Lessa , De Carvalho Cristiane Rodrigues , Valeriano Daniella Alighiene de Carvalho , Regis Cinthia Ferreira , Jatobá Joana D"'Arc Vila Nova
Published: January 2021

Introdução: As consequências evolutivas do quadro clí­nico da hansení­ase trazem inúmeras sequelas degenerativas que além da dor vivenciada, impactam em prejuí­zos fí­sicos, psí­quicos e socioculturais. Objetivo: Realizar um resgate etnobibliográfico sobre a evolução social e clí­nica da hansení­ase no Estado de Pernambuco. Métodos: Estudo discursivo-textual de natureza etnobibliográfica ancorada na obra "História Vivida na Terra dos Esquecidos". Resultados: A evolução da hansení­ase está correlacionada a decisões polí­ticas e a estratégias de controle, que redefiniram os conceitos sobre a patologia, a partir da própria história da saúde pública no Brasil. Conclusão: A evolução clí­nica da hansení­ase a conduziu de uma doença grave, altamente contagiosa, que conduzia ao internamento compulsório em leprosários e isolamento social para doença crônica curável com tratamento disponí­vel de forma gratuita no Sistema Único de Saúde. Os dados descritos demonstram evolução social da doença e a associa í  eficácia das polí­ticas públicas voltadas ao paciente hansênico através da redução do í­ndice de mortalidade pela doença.Palavras-chave: hansení­ase, história, saúde pública.Â
An Analysis of Polysemy of “anding-andingen” Proverb in Karo Language: Problems of Natural Semantic MetaLanguage
Authors: Tarigan Karisma E. , Mulyadi Mulyadi
Published: January 2021

This article aims at proposing a way to identify polysemy ‘anding-andingen’ or proverb in bahasa karo. The writer has an interest to use proverb or anding-aningen in this study because in proverb contains a lot of semantic meaning. This study was conducted using the descriptive qualitative approach in nature; therefore it only describes the semantic knowledge theory. The results of this study indicate that the element DO may occur either with a subject (Actor) alone with a second (Patient) argument as well (in English, as DO TO). It opened the way for a new semantically-inspired approach to grammar constructions. An analysis of ‘X does this’ as ‘X can say this’ and of ‘A because B’ as if not B, the not A’, the writers admitted that both DO and BECAUSE into the stable of semantic primitives. A similar entailment-like relationship obtains between PEOPLE and SOMEONE, but there is at least one significant syntactic difference, namely, that PEOPLE cannot occur with quantifier ONE.
Implementation of the E-Pocket Book to Improve Learning Outcomes in Economics at Madrasah Aliyah Madinatussalam, Bandar Khalifah Regency, Indonesia
Authors: Afrianti Nur , Ruslan Dede , Yusuf Muhammad
Published: January 2021

Teaching materials playing a vital role in supporting the learning process in a classroom. The right teaching materials will make the learning process more effective. The problem that is often faced by students is the teaching materials that are not appropriate, so that it lowers student learning outcomes. This causes the low learning outcomes of students in class XI economics MA Madinatusallam. For this reason, researchers try to investigate the effectiveness of e-pocketbook teaching materials. Field test results showed that the experimental class obtained higher learning outcomes than the control class, with a significant difference (p = <.05).
The Difficulty Analysis of Students Spatial Ability Based on Level Van Hiele in Problem Based Learning
Authors: Chairunnisa Chairunnisa , Surya Edy , Sinaga Bornok
Published: January 2021

This study aims to (1) determine the level of students' spatial ability at Van Hiele's level in problem-based learning. (2) to find out the location of the students' difficulties in solving spatial power problems with the Van Hiele level. This research is a qualitative descriptive study. The subjects of this study were students of class XII SMK Bima Utomo Batang Kuis. The object of this research is the spatial ability based on Van Hiele's level in Problem Based Learning. The results of this study indicate that the level of spatial ability in the low category reaches 51.4%, while the medium category reaches 34.3%, and the high category reaches 14.3%. Subjects in the low category experienced skill difficultiesSubject S.01 (low spatial ability), at Level 1 experienced skill difficulties (question number 1) and concept difficulty (question number 4), at Level 2 experienced skill difficulties, at Level 3 and Level 4 experienced difficulty in principle. Subject S.02 (low spatial ability), has difficulty skills at Level 2 and has difficulty in principle at Level 3 and Level 4. Subject S.03 (moderate spatial ability), has difficulty in principle at Level 3 and Level 4. Subject S. 04 (moderate spatial ability), has difficulty skills at Level 3 and has difficulty in principle at Level 4. Subject S.05 (high spatial ability), has difficulty in principle at Level 4. Subject S.06 (high spatial ability), has difficulty principles at Level 4.Based on the results of this study, it is expected to be an inspiration for users.
Development of Educational Game Media Based on Problem Based Learning in German Language in the First Grade Senior High School Students SMA Negeri 1 Sibolga
Authors: Marbun Syahraini
Published: January 2021

This study aims to: (1) determine the feasibility of problem-based learning educational game media in German language learning (2) to determine the effectiveness of using problem-based learning-based educational game media on German language material. This type of research is development research using the ASSURE product development model and combined with the Dick and Carey learning design model. This research was conducted on class X students at senior high school   SMA Negeri 1 Sibolga. The method used in this research is a quasi-experimental method. The research sample consisted of 60 students consisting of 30 students as an experimental class who were taught using educational game media based on problem based learning and 30 students as a control class who were taught using youtube-based learning media. The results of hypothesis testing prove that there is a significant difference between the learning outcomes of students who are taught about self-introduction in German using problem-based educational game learning media and students who are taught using YouTube-based learning media. This is shown by the data acquisition, namely tcount = 11.27 while ttable = 1.695, at a significant level of 0.05 through interpolation ttable 1.695. It is concluded that the effectiveness of German language learning using problem-based educational game learning media is higher than using Youtube-based learning media.
The Existency of Traditional and Modern Dance in Medan City
Authors: Martozet Martozet
Published: January 2021

The purpose of this study was to determine the existence or existence of traditional dances and modern dances in Medan. The research problem focuses on the existence of these two dance forms, how is the journey of traditional dance forms from the pre-independence era to the present and the glories of the emergence of new, modern-style dance forms from the 1960s, especially in the city of Meda. In order to approach this problem, the theory of existence is used WJS Poerwadaminta. Apart from that, it was also emphasized aboutunderstanding of traditional and modern dance by Indonesian dance expertsSoedarsono.While the data were collected through field observations, interviews, documentation, and literature study. Furthermore, the data obtained were analyzed through qualitative descriptive methods, narrating the data obtained in the field according to existing facts. From the research results it is known that the city of Medan as a large heterogeneous city, has traditional dances such as the Inai and Zapin Labuhan dances. Inai dance is performed at the evening ceremony, while Zapin Labuhan is performed at the apostolic circumcision ceremony.Zapin appeared in line with the existence of the Malays who lived in this area and were related to the existence of the Deli Sultanate. Zapin Labuhan developed during the reign of Tuanku Panglima Gandar Wahid in the 18th century AD, who was the King of Deli to V. Zapin.consists of several variants such as Zapin Anak Ayam, Zapin Pecah Tiga, Zapin Elang, Zapin Selendang, Zapin Lancang Kuning, Zapin Zat, Zapin Gergaji, and Zapin Zig-Zag.
Development of Mandailing Culture-Based Learning Devices with an Open-Ended Approach to Improve Students 'Mathematic Connection and Self-Efficiency Abilities SMPN 2 Batangtoru
Authors: Siregar Ajizah , Sinaga Bornok , Syahputra Hermawan
Published: January 2021

This study aims to: 1) describe learning tools with an open-ended approach that meets the criteria of being valid, practical, and effective; 2) Describe the improvement of mathematical connection ability using learning tools with the developed open-ended approach; 3) Describe the increase in ability self efficacy by using learning tools with the developed open-ended approach. This research is a development research conducted in two stages. Learning tools produced from this research are: Learning Implementation Plan (RPP), Student Worksheet (LKPD), Student Book (BS), mathematical connection ability test and questionnaire. Self efficacy students. From the results of the first trial and second trial, it was obtained: 1) the learning device with the Open-ended approach developed had been meet the criteria of being valid, practical, and effective in terms of their respective criteria;2) there was an increase in the students' mathematical connection ability using learning tools with an open-ended approach developed in the first trial, obtaining an average posttest score of 61.76, and an increase in the second trial with an average posttest score of 82.35; 3) there is an increase in ability self efficacy students using learning tools with an open-ended approach developed in the first trial obtained a value of 68.64 and increased in the second trial with a value of 87.52. Based on the results of the study it is suggested that mathematics teachers strive for mathematics learning using an open-ended learning approach and the learning tools developed can improve mathematical connection skills and self efficacy students in mathematics learning.
Development of Mathematics Teaching Materials Based on the Realistic Mathematics Approach (PMR) to Improve the Mathematical Reasoning and Representation Ability of Class VII Students of SMP Muhammadiyah 47 Medan Sunggal
Authors: Aleslami Ibnu Raash , Minarni Ani , Fauzi KMS. M. Amin
Published: January 2021

This study aims to analyze the validity and effectiveness of teaching materials developed based on a realistic mathematical approach in improving students 'mathematical reasoning and representation abilities, to analyze the increase in students' reasoning skills and mathematical representation abilities taught using teaching materials based on realistic mathematical approaches. The data were obtained through the validation sheet of teaching materials, observation sheets, student response questionnaires, mathematical reasoning ability test instruments and mathematical representation ability tests. This study uses a 4-D development model Thiagarajan, Semmel and Semmel by developing teaching materials with a realistic mathematical approach. Based on the results of the validation, the total average value of the RPP validity was 4.81, the student books were 4.83 and the LKPD was 4.85, the students' mathematical reasoning ability tests and the mathematical representation ability tests were in the valid category. Classical mastery of learning reaches 90.62% which has met the completeness criteria, namely ≥85% of students have reached the KKM. The increase in students' mathematical reasoning abilities using teaching materials based on a realistic mathematical approach on fraction material seen from N-Gain in the first trial and second trial has increased from 0.36 to 0.50 meaning that it is in the medium category. As well as an increase in the ability of students' mathematical representation using teaching materials based on a realistic mathematical approach on fraction material seen from N-Gain in the first trial and second trial, it increased from 0.43 to 0.50, meaning that it was in the medium category.
Development of Mathematics Teaching Materials to Improve Students' Critical Thinking Ability with Realistic Mathematics Learning Approach (PMR) Class VIII MTsS PP Al - Qomariah Galang
Authors: Asiyah Nur , Siagian Pargaulan , Fauzi KMS. M. Amin
Published: January 2021

This study aims to determine the validity, practicality and effectiveness of the developed teaching materials, as well as to determine the improvement of students' critical thinking skills using the developed teaching materials. Data obtained through the validation sheet of teaching materials, observation sheets, student response questionnaires, and critical thinking skills test instruments. This study uses the 4-D development model Thiagarajan, Semmel and Semmel (1974) by developing mathematics teaching materials with a realistic mathematics approach. Based on the results of the validity of the learning tools developed, it was included in the valid category with an average value of the total validity of students' books of 4.50, LKPD of 4.62 and the critical thinking ability test in the valid category. The effectiveness of learning devices that meet the effective criteria with the achievement of student learning completeness with a classical completeness percentage of 86.1%., Active student activities meet the ideal time tolerance criteria set, and student responses to learning devices are in good categories. And the average increase in students' critical thinking skills from trial I to trial II was 0.34 points with an increase in classical learning completeness of 17.35%.
Taakankantajat
Authors: Nykänen Elise
Published: January 2021

Artikkelissani tarkastelen kielteisten tunteiden, kuten ahdistuksen ja syyllisyyden, esityksiä ja tunne-efektejä Tapion vuonna 1956 ilmestyneessä romaanissa Aapo Heiskasen viikatetanssi. Osoitan, kuinka ironialle tyypillinen rakenteellinen ja temaattinen kaksikasvoisuus kytkeytyy romaanissa sekä kotimaisen kansankuvauksen tradition että eksistentialistis-filosofisen kirjallisuuden tunnekuvaston muunteluun ja parodiointiin. Kuvatessaan rintamalta palaavan sotamiehen mielen järkkymistä romaani kommentoi erityisesti 1940-luvulla ilmestyneitä kotiinpaluukertomuksia sekä sota-ajan tunneyhteisössä vallinnutta isänmaallisen uhrautuvuuden eetosta. Katoavan idyllin kuvauksissa korostuu päähenkilön ahdistus ja vieraantuminen omasta kansallisesta alkuperästään sekä syyllisyys, jota vanhoista arvoista ja ihanteista luopuminen aiheuttaa. Romaani rakentaa lukijalle vaihtoehtoisia yleisöpositioita, jotka perustuvat erilaisten kulttuurishistoriallisten tunneyhteisöjen olemassaoloon ja vastaanoton malleihin. Teoksen tunnevaikutukset liikkuvat eettisestä vieraantumisesta päähenkilön kärsimyksen tunnistamiseen ja esteettiseen etäännyttämiseen sen mukaisesti, millaiseen vastaanottaja-asemaan lukija ironisen kerronnan kutsumana kulloinkin asettuu.
Atividade alelopática de caju-de-árvore-do-cerrado sobre a germinação e crescimento de alface e rabanete
Authors: Arcanjo Waleska , Silva Lilian dos Santos , Bitencourt Raphaela Gabrí , Aguiar Ana Carolina Ribeiro , Ramos Luciana Machado , Chaves Andréa Rodrigues , Andrade Rômulo Davi Albuquerque
Published: January 2021

O estudo da atividade alelopática vem sendo utilizado no combate e controle de doenças, insetos e plantas daninhas. Este trabalho teve por objetivo avaliar o efeito alelopático de extratos das folhas de caju-de-árvore-do-cerrado (Anacardium othonianum Rizz.) na germinação e no crescimento inicial de plântulas de alface (Lactuca sativa L.) e rabanete (Raphanus sativus L.). Inicialmente, foram obtidos extratos aquosos das folhas da planta in natura por dois métodos de extração aquosa: infusão e decocção. Os bioensaios de germinação e crescimento de alface e rabanete foram realizados em triplicata, com tratamentos compostos por seis diferentes diluições dos extratos, sendo feita a análise da porcentagem de germinação, comprimento de radículas e da parte aérea das plântulas após 7 dias de incubação, sob condições de temperatura e luz artificiais. Verificou-se a existência do potencial alelopático em ambos os extratos das folhas de caju-de-árvore-do-cerrado, pela sensibilidade observada nas sementes de alface e rabanete. Além disso, constatou-se que os efeitos dos aleloquímicos são dependentes da dosagem utilizada, já que foram observadas variações nos efeitos alelopáticos (inibitório e/ou estimulante) apenas alterando a concentração aplicada dos extratos.
Effect of the curcumin and piperine co-administration on the blood lipid levels and the cardiovascular risk: a systematic review
Authors: Simionatto Mackelly , Rech Katlin Suellen , Gomes Mona Lisa Simionatto , Manfron Jane , Farago Paulo Vitor
Published: January 2021

Some plant species show medicinal potential in atherosclerosis and other coronary diseases. Curcumin (CUR) is a yellow-colored phenolic compound from rhizomes of Curcuma longa L. that is mainly used as anti-inflammatory, antioxidant, and anticancer. Piperine (PIP) is an alkaloid from the fruits and the seeds of Piper nigrum L. and Piper longum L. It has several pharmacological activities, including the antioxidant and the immunomodulatory properties. PIP also increases the nutrients absorption. This review aims at investigating the effect of the CUR and PIP co-administration on the lipid profile and the cardiovascular events based on animal and human studies. This study was performed in the main scientific search bases. Among the 4,992 references found, 2,004 papers were initially chosen for the partial reading and 15 of them filled all the selection criteria for the entire reading. The CUR and PIP co-administration generally demonstrated positive effects on lipid profile in animals and humans by reducing total cholesterol, triglycerides, and LP(a) and by increasing HDL-c. In spite of no long-term clinical trial was carried out for investigating the effect of CUR and PIP co-administration on cardiovascular events, the reduction of glucose, AST, and ALP, and the increase of CAT and SOD were recorded as secondary serum markers to avoid the cardiovascular risk. Therefore, the studies usually report that co-administration of CUR and PIP shows efficacy for reducing serum lipids. The effect on preventing cardiovascular events by reducing the cardiovascular risk is lacking of direct evidence.
Estudo de Eventos – Análise das decisões do Conselho Administrativo de Defesa Econômica em fusões e aquisições nos setores de energia elétrica e telecomunicações
Authors: Ferreira Julie Lima , Araújo Jonathans Oliveira Campos de , Viana Jade Vitor , Silva Francisco Gildemir Ferreira da
Published: January 2021

Diante das situações que o mercado financeiro pode passar, fusões e aquisições têm grandes impactos na eficiência de mercado, como abordado na teoria clássica das finanças. Diante disso, o seguinte trabalho se baseia na Hipótese de Mercados Eficientes para a aplicação do método de Estudo de Eventos para a análise de Fusões e Aquisições (F&A) dos setores regulados de Energia Elétrica e Telecomunicações no Brasil, a fim de verificar se as decisões de permissão das fusões por parte do Conselho Administrativo de Defesa Econômica (CADE) foram assertivas e se não tiveram impacto anticompetitivo no mercado. Para cada setor foi utilizado uma variação do método do Estudo de Eventos quanto as janelas de tempo analisadas, mas sua metodologia foi mantida. Para o setor de Energia elétrica foi contemplado as fusões de Enel x CELG, de 2017, e Enel x Eletropaulo, de 2018, e para o setor de Telecomunicações foi analisado a aquisição Telefônica x GVT, de 2018. Com a aplicação do método não há evidência de interferência no mercado competitivo, na ótica do mercado de capitais, para todos os eventos contemplados, mostrando assim que as decisões do CADE se mostraram corretas e o mercado se comportou de maneira eficiente.
Role of incubation environment in determining thermal tolerance of sea turtle hatchlings
Authors: Gatto CR , Matthews B , Reina RD
Published: January 2021

Warming global temperatures are predicted to reduce population viability in many oviparous ectothermic taxa, with increased embryonic mortality likely to be a main cause. While research on embryonic upper thermal limits is extensive, sea turtle hatchling thermal tolerance has received less attention and our understanding of how incubation conditions influence hatchling thermal tolerance is limited. Here, we report green turtle Chelonia mydas hatchling hydration and thermal tolerance following incubation in dry and wet conditions. We used packed cell volume and total protein as indicators of hydration and measured the critical thermal maximum (CTmax) of hatchlings in air. Neither hydration nor thermal tolerance was directly influenced by moisture treatment. However, hatchlings from moister nests had longer incubation durations (wet: 60.11 d vs. dry: 54.86 d), and, using incubation duration as a proxy for incubation temperature, hatchlings from cooler nests had significantly lower CTmax (wet: 39.84°C vs. dry: 40.51°C). Thus, despite not directly influencing thermal tolerance, moisture treatment influenced nest temperature indirectly; hatchlings that experienced warmer conditions in dry nests had a higher thermal tolerance than hatchlings from cooler and wetter nests. Ectothermic neonates may have greater plasticity in their thermal tolerance than previously thought, but their ability to adapt to increasing temperature is likely limited. Additionally, common management techniques to reduce nest temperatures, such as watering and shading nests, may only reduce embryonic mortality at the cost of decreased hatchling thermal tolerance and increased hatchling mortality during emergence. Nesting-site management interventions designed to reduce embryonic mortality will need to consider mitigation of the possible effects of those interventions on hatchling mortality.
Eco-innovative Mechanisms of Tourism Development in the Aral Sea Region
Authors: Halimova M.
Published: January 2021

The article discusses innovative mechanisms for the development of ecological tourism in Karakalpakstan and in the zone of the ecological crisis — the Aral Sea region, analyzes the current state and prospects of eco-innovative formation of the tourism industry in the Aral Sea region. Through the prism of the possibilities of using the tourism potential of the region, innovative mechanisms for implementing the regional development strategy are analyzed, problematic shortcomings are identified that occur in the process of implementing state and international programs aimed at eliminating the consequences of the drying up of the Aral Sea and the effective organization of ecological tourism in the areas adjacent to it. Analysis of the current state and prospects for the development of ecological tourism and its innovative component allowed the author to formulate specific recommendations for eliminating the shortcomings and improving the innovative mechanisms for the development of ecotourism in the region.
Energy and Economic Efficiency of Cultivation of Legumes
Authors: Mammadova Sh.
Published: January 2021

The article presents materials of the influence of various norms of organic and inorganic fertilizers on the bioenergetic and economic efficiency of vegetable beans. Comparison of the studied options shows that the bioenergetic efficiency of vegetable beans is the most rational in the N30P30K30 option. The intensive technology of growing vegetable beans is energy efficient, since the energy supply of all options for applying organic and inorganic fertilizers is more than one unit.
Optimization of Rehabilitation of Frequently Ill Children
Authors: Suvorov S. , Tolstokorov S.
Published: January 2021

The article provides data from studies conducted on the basis of the Saratov State Medical University on the prevention of respiratory diseases using physiotherapy and exercise therapy. In the course of the measures taken, a decrease in the incidence rate among children of this group was noted.
Prognosis the Incidence Rate of Ear and Mastoid Diseases in the Kyrgyz Republic
Authors: Nasyrov V. , Beishenbaeva B.
Published: January 2021

The article presents the prognosis of ear disease and mastoid disease in the adult population and adolescents in the Kyrgyzstan according to the National Statistical Committee. For the predictive trend, the logarithmic trend line was chosen as the most appropriate.
Prognosis the Incidence Rate of Allergic Rhinitis in Children and Adults in the Kyrgyz Republic
Authors: Beishenbaeva B.
Published: January 2021

Based on static data for the period 2010-2019. Submitted by the National Statistical Committee of the Kyrgyz Republic, an analysis of the overall incidence of allergic rhinitis in the child and adult population of the Kyrgyz Republic was carried out. A logarithmic prognostic trend line was drawn for general morbidity and children aged 0 to 14 years.
Assessment of Changes in the Level of Somatotropic Hormone, Cortisol and Blood Glucose in Adolescents With Meningitis of Different Etiology
Authors: Beregovoi A. , Dzholbunova Z.
Published: January 2021

This article provides a comparative description of changes in the level of growth hormone and blood cortisol in adolescents with the development of meningitis of various etiologies. The study was conducted in 2019 on 48 patients aged 10 to 19 years. In comparison, the groups of patients with acute bacterial and serous meningitis are presented. The results of the study help to determine what metabolic disorders can occur with meningitis of various etiological agents, which aggravates the course of the disease, increases the risk of complications and death, as well as to build a tactics of treatment and management of such patients. Particular attention is paid to the development of stress hyperglycemia — a condition that significantly aggravates the course of a generalized infectious and inflammatory process and increases the risk of complications from many body systems.
Information System for Registration of Research Results of a Synthetic Chemist
Authors: Dmitrieva Yu. , Limanova N. , Gubin V.
Published: January 2021

This article describes the information system, which is an electronic version of the laboratory journal of chemist-synthetics. An overview of the basic functionality of the program is presented.
Development of the Energy Circuits of Development of Contour Regulation of the Supply of Hot Water for Buildings With Variable Flow
Authors: Shan J. , Li J. , Guo Z. , Levtsev A.
Published: January 2021

The hot water supply system is one of the important components of the water supply and drainage system of high-rise civil buildings. With the development of the national economy and the improvement of people’s living standards, people’s requirements for popularizing hot water supply and improving hot water supply technology are becoming more and more urgent. In the process of hot water supply, the flow pressure of the pipeline is increased, and the purpose of hot water supply in high-rise buildings is achieved. The experiment analyzes the effect of the pressure ratio on the pipeline in front of the accumulator and the impact valve on the flow of coolant through the check valve. First, through the periodic opening and closing of the shock valve, the pressure continues to rise and fall, and the spring hose exhibits periodic pulsation. The effects of different pressure ratios on pipeline pressure and flow rate are studied, and the data of simulation calculation and actual measurement are analyzed through experiments. The research results have practical significance for improving the water supply efficiency of the hot water supply system of high-rise buildings.
Study of the Separation of Wood Resin Into Organic Fractions Based on Individual Boiling off of Substances
Authors: Toktorbaeva G. , Tashpolotov Y. , Ysmanov E.
Published: January 2021

Pyrogenic gums of walnut shells are raw materials for various commercial products, for example, phenols. In the process of pyrolysis, valuable organic products are formed: volatile gases — 33.5%, liquid substances (organic substances) — 35% and charcoal — 31.4%. In this work, we studied the chemical composition of the fraction of the pyrolysis resin of walnut shells using a TKP-160 Cr-MIUKhL thermostat using a refrigerator. In the resin reactor, the following products were separated: light, phenolic, naphthalene, absorbent, anthrocene and pitch. It has been established that the separated organic fractions depend on the individual boiling off of substances.
Clinical value of echocardiography in patients with COVID-19: a systematic review
Authors: Alekhin M. N. , Ivanov S. I. , Stepanova A. I.
Published: January 2021

This systematic review is dedicated to the role of echocardiography in diagnostics of possible cardiovascular complications in patients with COVID-19, the emerging infectious disease that has recently challenged global healthcare. The results of the largest current available clinical studies on the given topic from the leading medical databases were analyzed. Up-to-date data about the beneficial advantages and possible limitations of the use of echocardiography in the highly contagious disease pandemic is provided.
Basic paradigms of antidepressants use in real clinical practice
Authors: Putilina M. V. , Teplova N. V. , Chervyakova G. A. , Eryomina Yu. N.
Published: January 2021

The article is devoted to the basic principles of diagnosis and treatment of anxiety-depressive disorders. The indications, features of the use of antidepressants are considered separately on the example of drugs of the class of selective serotonin reuptake inhibitors. The advantages of Sertraline as the only dopamine-sparing’ antidepressant with a high degree of safety and a minimal risk of unwanted drug interactions are described.
Filaminopathy type C
Authors: Kopishinskaia S. V. , Lesnikova A. A. , Abramova D. I. , Velichko I. A.
Published: January 2021

Filamin is an actin-binding protein that, by forming flexible molecular cross-links, stabilizes the three-dimensional F-actin networks and gives them the mechanical properties of a gel. It is represented by three isoforms: filamine A (FLNA), filamin B (FLNB), and filamin C (FLNC), derived from 3 homologous genes. Laminopathies caused by mutations in the FLNA, FLNB, and FLNC genes represent an extensive allelic series of diseases. The review discusses in detail the genotype-phenotypic correlation of all types of phylaminopathies. The neuromuscular and cardiac clinic of C-type phylaminopathy is described in detail. Three variants of C phylaminopathy known at the moment are analyzed.
Parental Monitoring of Academics and Adolescents’ Engagement in Substance Use
Authors: Goswami Debadutta , Thompson Kip R.
Published: January 2021

Lifelong substance use often begins during adolesence. Eighty eight percent of adult daily smokers began before age 18. By 12th grade, about two-thirds of student have tried alcohol; approximately half of 9th through 12th grade students have reported ever having used marijuana; and among 12th graders, approximately 2 in 10 reported using prescription medicine without a prescription. Adolescents reporting lower levels of parental monitoring are more likely to use illicit substance (primarily cannabis use). Poor parental monitoring is associated with many negative youth outcomes, including maladjustment, association with deviant peers, and poor performance in school. The purpose of this research was to determine if parental involvement in student academics, specifically parental checking student homework and parental help with student homework, were significantly associated with substance use based on data from the 2018 National Survey on Drug Use and Health (NSDUH). The results of this study indicate both parental checking of homework and helping with homework are strongly and significantly associated with a reduction in substance use by adolescents (p = 0.0001).
Control Theory and Cancer Chemotherapy: How They Interact
Authors: Lecca Paola
Published: January 2021

Control theory arises in most modern real-life applications, not least in biological and medical applications. In particular, in biological and medical contexts, the role of control theory began to take shape in the early 1980s when the first works appeared on the application of control theory in models of pharmacokinetics and pharmacodynamics for antitumor therapies. Forty years after those first works, the theory of control continues to be considered a mathematical analysis tool of extreme importance and usefulness, but the challenges it must overcome in order to manage the complexity of biological processes are in fact not yet overcome. In this article, we introduce the reader to the basic ideas of control theory, its aims and its mathematical formalization, and we review its use in cell phase-specific models for cancer chemotherapy. We discuss strengths and limitations of the control theory approach to the analysis pharmacokinetics and pharmacodynamics models, and we will see that most of them are strongly related to data availability and mathematical form of the model. We propose some future research directions that could prove useful in overcoming the these limitations and we indicate the crucial steps preliminary to a useful and informative application of control theory to cancer chemotherapy modeling.
Polyhydroxyalkanoate Synthesis by Burkholderia glumae into a Sustainable Sugarcane Biorefinery Concept
Authors: de Paula Carolina Bilia Chimello , de Paula-Elias Fabrício Coutinho , Rodrigues Marcela Nogueira , Coelho Luciana Fontes , de Oliveira Nayra Morgana Lima , de Almeida Alex Fernando , Contiero Jonas
Published: January 2021

Polyhydroxyalkanoate (PHA) bioplastic was synthesized by Burkholderia glumae MA13 from carbon sources and industrial byproducts related to sugarcane biorefineries: sucrose, xylose, molasses, vinasse, bagasse hydrolysate, yeast extract, yeast autolysate, and inactivated dry yeast besides different inorganic nitrogen sources. Sugarcane molasses free of pre-treatment was the best carbon source, even compared to pure sucrose, with intracellular polymer accumulation values of 41.1–46.6% cell dry weight. Whereas, xylose and bagasse hydrolysate were poor inducers of microbial growth and polymer synthesis, the addition of 25% (v/v) sugarcane vinasse to the culture media containing molasses was not deleterious and resulted in a statistically similar maximum polymer content of 44.8% and a maximum PHA yield of 0.18 g/g, at 34°C and initial pH of 6.5, which is economic and ecologically interesting to save water required for the industrial processes and especially to offer a fermentative recycling for this final byproduct from bioethanol industry, as an alternative to its inappropriate disposal in water bodies and soil contamination. Ammonium sulfate was better even than tested organic nitrogen sources to trigger the PHA synthesis with polymer content ranging from 29.7 to 44.8%. GC-MS analysis showed a biopolymer constituted mainly of poly(3-hydroxybutyrate) although low fractions of 3-hydroxyvalerate monomer were achieved, which were not higher than 1.5 mol% free of copolymer precursors. B. glumae MA13 has been demonstrated to be adapted to synthesize bioplastics from different sugarcane feedstocks and corroborates to support a biorefinery concept with value-added green chemicals for the sugarcane productive chain with additional ecologic benefits into a sustainable model.
Unveiling the Importance and Evolution of Design Components Through the “Tree of Blockchain”
Authors: Spychiger Florian , Tasca Paolo , Tessone Claudio J.
Published: January 2021

This study covers the evolutionary development of blockchain technologies over the last 11 years (2009–2019) and sheds lights on potential areas of innovation in heretofore unexplored sub-components. For this purpose, we collected and analyzed detailed data on 107 different blockchain technologies and studied their component-wise technological evolution. The diversity of their designs was captured by deconstructing the blockchains using the Tasca-Tessone taxonomy to build what we call the “tree of blockchain” composed of blockchain main and sub-components. With the support of information theory and phylogenetics, we found that most design explorations have been conducted within the components in the areas of consensus mechanisms and cryptographic primitives. We also show that some sub-components like Consensus Immutability and Failure Tolerance, Access and Control layer, and Access Supply Management have predictive power over other sub-components. We finally found that few dominant design models—the genetic driving clusters of Bitcoin, Ethereum, and XRP—influenced the evolutionary paths of most of the succeeding blockchains.
Integrated Metabolomics and Lipidomics Analysis Reveal Remodeling of Lipid Metabolism and Amino Acid Metabolism in Glucagon Receptor–Deficient Zebrafish
Authors: Bai Xuanxuan , Jia Jianxin , Kang Qi , Fu Yadong , Zhou You , Zhong Yingbin , Zhang Chao , Li Mingyu
Published: January 2021

The glucagon receptor (GCGR) is activated by glucagon and is essential for glucose, amino acid, and lipid metabolism of animals. GCGR blockade has been demonstrated to induce hypoglycemia, hyperaminoacidemia, hyperglucagonemia, decreased adiposity, hepatosteatosis, and pancreatic α cells hyperplasia in organisms. However, the mechanism of how GCGR regulates these physiological functions is not yet very clear. In our previous study, we revealed that GCGR regulated metabolic network at transcriptional level by RNA-seq using GCGR mutant zebrafish (gcgr−/−). Here, we further performed whole-organism metabolomics and lipidomics profiling on wild-type and gcgr−/− zebrafish to study the changes of metabolites. We found 107 significantly different metabolites from metabolomics analysis and 87 significantly different lipids from lipidomics analysis. Chemical substance classification and pathway analysis integrated with transcriptomics data both revealed that amino acid metabolism and lipid metabolism were remodeled in gcgr-deficient zebrafish. Similar to other studies, our study showed that gcgr−/− zebrafish exhibited decreased ureagenesis and impaired cholesterol metabolism. More interestingly, we found that the glycerophospholipid metabolism was disrupted, the arachidonic acid metabolism was up-regulated, and the tryptophan metabolism pathway was down-regulated in gcgr−/− zebrafish. Based on the omics data, we further validated our findings by revealing that gcgr−/− zebrafish exhibited dampened melatonin diel rhythmicity and increased locomotor activity. These global omics data provide us a better understanding about the role of GCGR in regulating metabolic network and new insight into GCGR physiological functions.