bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis, Electronic Structure and Anti-Cancer Activity of the Phenyl Substituted Pyrazolo[1,5-a][1,3,5]triazines
Authors: Velihina Evgenia S. , Obernikhina Nataliya V. , Pilyo Stepan G. , Kachkovsky Oleksiy D. , Brovarets Volodymyr S.
Published: June 2021

Background:

Synthesis of a series of 2-(dichloromethyl)pyrazolo[1,5-
a][1,3,5]triazines was carried out and evaluated in vitro for their anticancer activity against a
panel of 60 cell lines derived from nine cancer types.

Methods:

The joint quantum-chemical and experimental study of the influence of the extended
πconjugated phenyl substituents on the electron structure of the pyrazolo[1,5-
a][1,3,5]triazines as Pharmacophores were performed. It is shown that the decrease in the
barriers to the rotation of phenyl substituents in compounds 1-7 possibly leads to an increase
in the anti-cancer activity, which is in agreement with the change in the parameter biological
affinity Φ0. Analysis of the S0 → S1 electronic transitions (π→π*) of the pyrazolo[1,5-
a][1,3,5]triazines shows that an increase in their intensity correlates with anti-cancer activity.

Results:

Thus, the introduction of phenyl substituents increases the likelihood of investigated
pyrazolo[1,5-a][1,3,5]triazines interacting with protein molecules (Biomolecule) by the π-stacking mechanism. In
both methyl and phenyl derivatives of pyrazolo[1,5-a][1,3,5]triazines, the second electronic transition includes the n-
MO (the level of the lone electron pair in two-coordinated nitrogen atoms). The highest intensity of the η→π* electronic
transition is observed in pyrazolo[1,5-a][1,3,5]triazine with pyridine residue, which does not exhibit anticancer
activity, but exhibits antiviral activity [13].

Conclusion:

It can be assumed that the possibility of the formation of [Pharmacophore-Biomolecule] complex by
hydrogen bonding ([H-B]) mechanism with protein molecules increases.
Thermostable α-Glucan Phosphorylase-catalyzed Enzymatic Chain-elongation to Produce 6-Deoxygenated α(1γ4)-Oligoglucans
Authors: Kadokawa Jun-ichi , Lee Le Hooi , Yamamoto Kazuya
Published: June 2021

:

Herein, the synthesis of 6-deoxygenated α(1γ4)-oligoglucans via thermostable αglucan phosphorylase (from Aquifex aeolicus VF5)-catalyzed enzymatic chain-elongation is
reported from a maltotriose primer using a non-native substrate, 6-deoxy-α-D-glucose 1-
phosphate. The enzymatic reaction of the two substrates mainly produced a tetrasaccharide
with one 6-deoxy-α-D-glucose unit at the non-reducing end, together with a minor pentasaccharide with two 6-deoxy-α-D-glucose units. The enzymatic chain-elongation from the primer
in the presence of 6-deoxy-α-D-glucose 1-phosphate and a native substrate, α-D-glucose 1-
phosphate, afforded 6-deoxygenated α(1γ4)-oligoglucans with varying degrees of polymerization. This enzymatic chain-elongation catalyzed by thermostable α-glucan phosphorylase is
an efficient method to produce non-natural oligosaccharides, that is, 6-deoxygenated α(1γ4)-
oligoglucans.
Expanding the Frontiers of the Right to Work through Migration: An Evolving Regime
Authors: Nnawulezi Uche , Adeuti Bosede
Published: June 2021

This paper explores the strategic interest in promoting the right to work through migration. Ideally, migrant workers whether under contract or other formal arrangements, or simply setting off on their own initiative should be given a basic understanding of the language, culture, legal, social, and political structures of the states to which they are going. This is really important given the complex nature of the rights of all migrant workers and members of their families, as an evolving regime that has faced difficulties in the implementation of their rights to work at the global level. This paper therefore set out to examine why most migrant workers experience challenges in securing employment, while some have to surmount far more barriers either before their departure, or at the time of their admission to the state of employment of all conditions applicable to their admission, as well as of the requirements they must satisfy in the state of employment and the authority to which they must satisfy in the state of employment and the authority to which they must address themselves for any modifications of those conditions. The methodology underpinning the research is essentially descriptive, thus, deductive logical “content analysis” is employed. This paper among other things argues that the consequences of migration and the situation of vulnerability in which migrant workers and members of their families frequently-find themselves cannot only be solved by having a functional fundamental human rights approach on the complexity of social, economics, and cultural issues prevalent in the migration regime. This paper concludes that with due respect to the author and to his concern for the protection and promotion of the right to work through migration, is to say the least, is a first step towards a sustainable promotion of the right to work through migration.
Land Procurement for Upstream Oil and Gas Business Activities in Indonesia
Authors: Subadi Subadi
Published: June 2021

This paper aims to provide an understanding and insight regarding land procurement for oil and gas exploration activities as well as the development of regulations or legal and policy breakthroughs that have so far not been or very little exposed. Land procurement has always been a serious obstacle or obstacle to oil and gas exploration activities in Indonesia. Land procurement for oil and gas exploration using a business to business (B to B) mechanism makes it very difficult for SKK Migas and the contractor. In recent years, the government has made legal breakthroughs to simplify and accelerate the land procurement mechanism for exploration activities. This study uses a normative juridical method supported by in-depth interviews with legal experts, land acquisition committees and landowners and has produced conclusions: First, the business to business (B to B) mechanism often faces obstacles and obstacles, such as; 1) refusal from the landowner; 2) inconsistency with the spatial layout; 3) there is a land dispute with other parties; 4) it is difficult for oil and gas contractors to process land certification. Second, the discretion which is considered as a legal breakthrough or new policy that is ideal in helping to smooth and accelerate the process of oil and gas production in Indonesia.
Alternative Dispute Resolution (ADR) Hybrid in Cameroon as a Form of Legal Protection for Consumers of Defective Products
Authors: Amandong Egute
Published: June 2021

As part of the awareness creation exercise, this paper seeks to establish that consumers of defective products in Cameroon should be exposed to the various extra-judicial channels once they can be adopted by Government and through which the consumers can enforce their rights. This is known as Alternative Dispute Resolution (ADR). The acronym ADR is a group of flexible approaches which could be applied in resolving disputes related to defective products more quickly and at a lower cost than going through the tedious road of adversarial proceedings. ADR mechanisms generally are intended to mean alternatives to the traditional court process. Their adoption will involve the use of impartial interveners who are referred to as “third parties” or “neutrals”. On the whole, the choice of a consumer redress mechanism is a choice between judicial and non-judicial mechanisms. The paper argues that, considering the difficulties encountered by the consumer within the adversarial system, the non-judicial mechanisms are more impactful and satisfactory to consumers than the judicial. It is equally argued that the judicial mechanisms depict a certain level of risk taking, that is, the risk of winning or losing and hence going without a remedy. This risk factor is much lower in the non or extra – judicial system or mechanism which reveals that in appropriate circumstances, the producers using the good customer relation basis, are minded to compensate even where the consumer’s claim is baseless. In this wise, it is therefore necessary to encourage the utilization of the extra - judicial mechanisms in resolving consumer complaints. Expediency, speed and low cost no doubt support this call.
Gender-Dependent Effects of Thimerosal on Human Progenitor Neurons: A Potential Link to Regressive Autism
Authors:   Claﬂin University, South Carolina Center for Biotechnology, 400 Magnolia Street, Orangeburg, SC 29115, USA, Goodwin Gregory R. , Shamabadi Narges Sadat ,   Environment Research Center, University of Qom, Qom, IRAN, Pandey Pratima ,   Claﬂin University, South Carolina Center for Biotechnology, 400 Magnolia Street, Orangeburg, SC 29115, USA, McLean Ewen ,   Aqua Cognoscenti LLC, West Columbia, SC 29170, USA, Bagasra Omar ,   Claﬂin University, South Carolina Center for Biotechnology, 400 Magnolia Street, Orangeburg, SC 29115, USA
Published: June 2021

Regressive Autism [RA] is a subtype of autism spectrum disorder (ASD) that manifests as the loss of previously acquired developmental milestones and skills. Early life dysregulation of neurodevelopment due to exposure to toxic metals has been associated with ASD, but the underlying biological mechanisms by which metals influence neurodevelopment remain unclear. We explored the potential role of thimerosal or ethylmercury on neurite formation and oxytocin receptor (OXTR) modulation in four human-developing neuronal cell lines of male and female origin (N = 2 each). We exposed the cell lines to three levels of thimerosal that closely represented the concentrations an infant (equivalent to 1 L of blood volume), an adolescent (~5 L), and an adult (~10 L) might receive from multiple doses of vaccine containing 100 µg/mL of thimerosal. We found that exposure to vaccine-equivalent concentrations of thimerosal induced significantly greater neurite dysregulation, including central chromatolysis, neurite abnormalities (i.e., axonal length, relative diameter, and pathways in neurons), and syncytia formation in undifferentiated and partially differentiated human developing neurons compared to controls. Exposure of male neurons to thimerosal significantly affected neurite formation and OXTR expression compared to the female neurons. In developed nations, most vaccines are thimerosal-free; nonetheless, some still incorporate ethylmercury as a preservative. In contrast, due to the lack of refrigeration in many developing nations, thimerosal is still used widely in most vaccines. Our study shows that ethylmercury induced profound neurite dysregulation and downregulated OXTR expression. The progenitor neurons from males were significantly more susceptible to thimerosal than those from females. However, internal factors in vaccine recipients may trigger dysfunction in the Blood-Brain Barrier (BBB), and screening potentially vulnerable individuals for conditions that may contribute to a BBB breach before vaccination might be beneficial.
Examination of PCDD/F Formation in Thermal Systems Using Simple Mathematical Models
Authors:   McIvor Park Court, Junortoun, Victoria 3551, Australia, Stanmore Brian R.
Published: June 2021

A set of empirical models which accounts for the formation of gas phase polychlorinated dibenzo-p-dioxins and furans (PCDD and PCDF), and solid phase PCDD/F by the de novo mechanism is described.In each case, competing formation and destruction reactions are considered to operate.The effect of the time-temperature history on their formation is then examined.At high temperatures, steady-state is reached in fractions of a second, resulting in the observed low product concentrations.Rapid cooling as found in furnaces produces higher PCDD/F nett formation rates than slower cooling over the same temperature range, but with less overall yield.In addition, a cooling process will result in more PCDD/F production than heating at the same rate. Thus the conventionally-regarded temperature “windows” for formation are misleading, as in practical conditions PCDD/F are produced at higher temperatures.Simulations carried out of a pilot scale municipal solid waste (MSW)incinerator, a commercial fluidised bed boiler burning wood as a fuel, and of the laboratory scale thermal “annealing” of particulates taken from iron ore sintering off-gases illustrate the effects.There is sufficient promise in the approach to suggest that better characterisation of particulates will lead to acceptable predictions.
Personal Health Information Management Among Older Adults: Scoping Review (Preprint)
Authors: Kolotylo-Kulkarni Malgorzata , Seale Deborah E , LeRouge Cynthia M
Published: June 2021

BACKGROUND

Older adults face growing health care needs and could potentially benefit from personal health information management (PHIM) and PHIM technology. To ensure effective PHIM and to provide supportive tools, it is crucial to investigate the needs, challenges, processes, and tools used by this subpopulation. The literature on PHIM by older adults, however, remains scattered and has not provided a clear picture of what we know about the elements that play a role in older adults’ PHIM.

OBJECTIVE

The goal of our review was to provide a comprehensive overview of extant knowledge on PHIM by older adults, establish the status quo of research on this topic, and identify research gaps.

METHODS

We carried out a scoping review of the literature from 1998 to 2020, which followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) framework. First, we executed a broad and structured search. We then carried out a qualitative analysis of papers pertinent to the topic taking into consideration the five elements of the patient work system as follows: (1) personal-level factors, (2) PHIM tasks, (3) tools used, (4) physical settings of PHIM activities, and (5) socio-organizational aspects.

RESULTS

The review included 22 studies. Consolidated empirical evidence was related to all elements of the patient work system. Multiple personal factors affected PHIM. Various types of personal health information were managed (clinical, patient-generated, and general) and tools were used (electronic, paper-based, and others). Older adults’ PHIM was intertwined with their surroundings, and various individuals participated. The largest body of evidence concerned personal factors, while findings regarding the physical environment of PHIM were scarce. Most research has thus far examined older adults as a single group, and scant attention has been paid to age subgroups.

CONCLUSIONS

Opportunities for further PHIM studies remain across all elements of the patient work system in terms of empirical, design science, or review work.
Understanding the Relationship Between Mood Symptoms and Mobile App Engagement Among Patients With Breast Cancer Using Machine Learning: Case Study (Preprint)
Authors: Baglione Anna N , Cai Lihua , Bahrini Aram , Posey Isabella , Boukhechba Mehdi , Chow Philip I
Published: June 2021

BACKGROUND

Health interventions delivered via smart devices are increasingly being used to address mental health challenges associated with cancer treatment. Engagement with mobile interventions has been associated with treatment success; however, the relationship between mood and engagement among patients with cancer remains poorly understood. A reason for this is the lack of a data-driven process for analyzing mood and app engagement data for patients with cancer.

OBJECTIVE

This study aimed to provide a step-by-step process for using app engagement metrics to predict continuously assessed mood outcomes in patients with breast cancer.

METHODS

We described the steps involved in data preprocessing, feature extraction, and data modeling and prediction. We applied this process as a case study to data collected from patients with breast cancer who engaged with a mobile mental health app intervention (IntelliCare) over 7 weeks. We compared engagement patterns over time (eg, frequency and days of use) between participants with high and low anxiety and between participants with high and low depression. We then used a linear mixed model to identify significant effects and evaluate the performance of the random forest and XGBoost classifiers in predicting weekly mood from baseline affect and engagement features.

RESULTS

We observed differences in engagement patterns between the participants with high and low levels of anxiety and depression. The linear mixed model results varied by the feature set; these results revealed weak effects for several features of engagement, including duration-based metrics and frequency. The accuracy of predicting depressed mood varied according to the feature set and classifier. The feature set containing survey features and overall app engagement features achieved the best performance (accuracy: 84.6%; precision: 82.5%; recall: 64.4%; F1 score: 67.8%) when used with a random forest classifier.

CONCLUSIONS

The results from the case study support the feasibility and potential of our analytic process for understanding the relationship between app engagement and mood outcomes in patients with breast cancer. The ability to leverage both self-report and engagement features to analyze and predict mood during an intervention could be used to enhance decision-making for researchers and clinicians and assist in developing more personalized interventions for patients with breast cancer.

CLINICALTRIAL
The holistic health status of Chinese homosexual and bisexual adults: a scoping review protocol (Preprint)
Authors: WU Chanchan , CHOI Edmond Pui Hang , CHAU Pui Hing , CHOI Kitty Wai Ying
Published: June 2021

BACKGROUND

There is a considerable number of homosexual and bisexual Chinese, while their health conditions have not received sufficient attention compared with general population. Referring to World Health Organization (WHO)’s definition, holistic health is a comprehensive concept incorporating physical, mental, and social well-being. However, existing research seems inadequate and unbalanced on the holistic health of this population, especially many studies only focus on sexually transmitted infections (STI) and relating prevention interventions. Apart from these, the health status of these sexual minorities from a holistic perspective remains unclear.

OBJECTIVE

This scoping review aims to comprehensively examine all available literature and will be the first to map the existing evidence on the holistic health of homosexual and bisexual Chinese.

METHODS

This proposed scoping review has been structured according to standard framework recommended by Joanna Briggs Institute (JBI). Pilot searches of PubMed in English and SinoMed in Chinese were completed to identify all relevant search terms or keywords, then a comprehensive search strategy has been carried out across all relevant databases centering on health care, psychology, nursing and social science, including totally 20 electronic databases covering both English and traditional as well as simplified Chinese. Screening and study selection has been independently conducted by two reviewers and consulting a third senior reviewer based on consensus needs. Data will be extracted using a structured data form and a narrative synthesis of the findings will be used.

RESULTS

The final database search has been conducted in May 2020, and totally yielded 14811 references from January 1st 2001 to May 31st 2020. After removing 4227 duplicates, there are 10584 references remained for further screen. As of May 2021, the full-text screening is just completed, and data extraction and charting is in progress. This review is projected to be completed by Fall 2021.

CONCLUSIONS

There is no systematically reviewed evidence available or underway review on the holistic health of either homosexual or bisexual Chinese, so this scoping review will serve as the first and most comprehensive way to map the existing evidence and draw a big picture of their health conditions. Results of this review can be used to inform scholars of existing health issues and other major needs, then to provide scientific references for the development of person-centered culturally sensitive programs with Chinese characteristics.

CLINICALTRIAL

This protocol has been registered within Open Science Framework (https://osf.io/82r7z) on April 27, 2020.
Comparison of Nursing Diagnostic Accuracy of a Knowledge-Based Clinical Decision Support System with Clinical Diagnostic Validity and Bayesian Decision Models for Psychiatric Care Plan Formulation among Nursing Students (Preprint)
Authors: Ho Kuei-Fang , Chou Po-Hsiang , Chung Min-Huey
Published: June 2021

BACKGROUND

Information technology can improve patient care plans to achieve high-quality care. However, few information systems can strengthen decision-making competency in health care environments. The most suitable and reliable inference engines for clinical decision support systems in nursing clinical practice have rarely been explored.

OBJECTIVE

This study examined the nursing diagnostic accuracy of a knowledge-based clinical decision support system (KBCDSS) based on clinical diagnostic validity (CDV) and the Bayesian decision models for nursing students to use during a psychiatric–mental health nursing practicum.

METHODS

A single-blinded, nonequivalent control group pretest–posttest design was adopted. Participants were 607 nursing students. In the quasi-experimental design, 2 intervention groups using a KBCDSS with the CDV (n=203) or the Bayesian decision (n=198) inference engine and a control group (n=206) used the psychiatric care plan system without guidance indicators to support decision-making.

RESULTS

Positive predictive value (PPV) and sensitivity indicated that decision-making competency was the highest for those in the CDV group followed by the Bayesian decision (BADE) and control groups. Relative to the control group, both the CDV and BADE groups exhibited significantly higher 3Q model questionnaire and modified TAM3 scores. In terms of perceived usefulness and behavioral intention, the CDV group had significantly higher 3Q model and modified TAM3 scores than did the BADE group, which had significantly higher scores than the control group did.

CONCLUSIONS

KBCDSSs can be adopted to provide empirical patient-oriented information and help nursing students rapidly manage patient information and formulate patient-centered care plans.
Polarity Effect on the Electronic Structure of Molybdenum Dichalcogenides MoXY (X, Y = S, Se): A Computational Study Based on Density-Functional Theory
Authors: Putri Salsabila Amanda , Suharyadi Edi , Absor Moh. Adhib Ulil
Published: June 2021

Computational research based on the Density Functional Theory (DFT) has been performed to explore the electronic structure of monolayer material Transition Metal Dichalcogenides (TMDCs) Molybdenum Dichalcogenides MoXY (X; Y = S; Se) in the first Brillouin zone by breaking its mirror symmetry due to the polarity effect. Our study discovered that Rashba spin-splitting could be identified around the Γ point by proposing the polarity effect on the system. Moreover, the anisotropic characteristic of Rashba spin-splitting in this system can be explicitly analyzed by using  perturbation theory and the third-order symmetry group analysis. By performing the spin textures analysis, this research also recognizes the in-plane direction of spin textures. The tunable characteristic of the Rashba parameter of this monolayer polar MoSSe system under the strain effects control exhibits its potential to be the candidate of semiconductor material for the Spin Field Effect Transistor (SFET) device.
Synthesis of Colloidal Silver Nanoparticles in Various Liquid Media Using Pulse Laser Ablation Method and Its Antibacterial Properties
Authors: Avicenna Syifa , Nurhasanah Iis , Khumaeni Ali
Published: June 2021

The silver nanoparticles (AgNPs) have been applied as an antibacterial agent in consumer products, cosmetics, and food industries. In this present work, AgNPs were synthesized in various mediums of polyvinylpyrrolidone (PVP), polyethylene glycol (PEG), and chitosan using the pulse laser ablation synthesis method. Experimentally, a pulse Nd:YAG laser beam (1064 nm, 7 ns, 30 mJ) was directed using a silver mirror and focused using a quartz lens with a focal length of 30 mm on a silver metal plate placed in a petri dish containing liquid mediums for 120 min to produce colloidal silver nanoparticles. The results certified that All AgNPs have a spherical shape with polydisperse size in all media, including PVP, PEG, and chitosan. The smallest AgNPs have been produced in PVP medium with an averaged smallest size of 11.62 nm. Based on this result, PVP is the preferred medium to produce AgNPs with the smallest size and good stability. The produced silver nanoparticles have been successfully employed as an antibacterial agent, which is experimentally demonstrated by using Escherichia coli and Staphylococcus aureus. The result certified that the produced silver nanoparticles could effectively kill the bacteria with a killing percentage of 99.6 to 100%.
A Theoretical Study on Vibrational Energies of Molecular Hydrogen and Its Isotopes Using a Semi-classical Approximation
Authors: Pingak Redi Kristian , Johannes Albert Zicko , Nitti Fidelis , Ndii Meksianis Zadrak
Published: June 2021

This study aims to apply a semi-classical approach using some analytically solvable potential functions to accurately compute the first ten pure vibrational energies of molecular hydrogen (H2) and its isotopes in their ground electronic states. This study also aims at comparing the accuracy of the potential functions within the framework of the semi-classical approximation. The performance of the approximation was investigated as a function of the molecular mass. In this approximation, the nuclei were assumed to move in a classical potential. The Bohr-Sommerfeld quantization rule was then applied to calculate the vibrational energies of the molecules numerically. The results indicated that the first vibrational transition frequencies (v1ß0) of all hydrogen isotopes were consistent with the experimental ones, with a minimum percentage error of 0.02% for ditritium (T2) molecule using the Modified-Rosen-Morse potential. It was also demonstrated that, in general, the Rosen-Morse and the Modified-Rosen-Morse potential functions were better in terms of calculating the vibrational energies of the molecules than Morse potential. Interestingly, the Morse potential was found to be better than the Manning-Rosen potential. Finally, the semi-classical approximation was found to perform better for heavier isotopes for all potentials applied in this study.
Retinal involvement of coronavirus disease (COVID-19): A systematic review
Authors: Prayogo Mohammad Eko , Agni Angela Nurini
Published: June 2021

COVID-19 has wide-ranging manifestations which involve various organs. Although COVID-19 is known to affect mainly the respiratory system, many patients suffered from ocular manifestations following SARS-CoV-2 infection, especially conjunctivitis. However, there was some evidence of broader ocular involvement, which could involve the retinal layer. This review aims to analyze the possible explanation of retinal involvement in COVID-19 and whether comorbidities increase the risk of retinal involvement in COVID-19. We conducted a systematic literature search during September 2020 using the PUBMED database and other additional sources (e.g., Google Scholar). There was no year of publication nor language restriction. Six papers are used in this literature review: two studies reported retinal lesions in COVID-19 patients, one study detected SARS-CoV-2 RNA in retinal biopsies and three studies proposed possible mechanisms of retinal involvement in COVID-19. Ocular structures express ACE-2, such as the aqueous humor, pigmented epithelium, and retina. This is supported by the finding of SARS-CoV-2 nucleic acid in postmortem patients. Retinal involvement in COVID-19 patients includes hyperreflective retina lesions, subtle cotton wool spots, and microhemorrhage. However, these findings do not necessarily indicate the specificity of retinal involvement. Diabetes mellitus may be associated with disease severity in patients with COVID-19. Some evidence of retinal involvement in SARS-CoV-2 infection involves the detection of retinal lesions, the expression of ACE-2 in the retina, and the role of comorbidities.
Diagonal Based Feature Extraction and Backpropagation Neural Network in Handwritten Batak Toba Characters Recognition
Authors: Zamzami Elviawaty Muisa , Hayanti Septi , Nababan Erna Budhiarti
Published: June 2021

Handwritten character recognition is considered a complex problem since one’s handwritten character has its characteristics.  Data used for this research was a photo of handwritten or scanned handwritten.  In this research, Backpropagation Neural Network (BPNN) was used to recognize handwritten Batak Toba character, wherein preprocessing stage feature extraction was done using Diagonal Based Feature Extraction (DBFE) to obtain feature value.  Furthermore, the feature value will be used as an input to BPNN. The total number of data used was190 data, where 114 data was used for the training process and another 76 data was used for testing. From the testing process carried out, the accuracy obtained was 87,19 %.
Rule-Based Bibliographic Computer Science Indexing Review with COVID-19 Disease
Authors: Andrianingsih Andrianingsih , Widyaningsih Tri Wahyu , Dewi Meta Amalya
Published: June 2021

A researcher in conducting his research usually uses a search through the homepage of the publication, based on expertise, collaboration in research, and research interests. Today, the COVID-19 pandemic is becoming a trending topic for researchers from various scientific fields. The study classified the case based on publications located in the homepage sources such as Scopus, Crossref, IEEE Xplore, and Google Scholar, by analyzing the following topics, namely Artificial Intelligence, Data Mining, Deep Learning, Machine Learning and the Internet of Things by using Named Entity Recognition to detect and classify named entities in text and using occurence and link strength methods. Based on this study, the results were obtained that Scopus has the most equitable percentage, which has a good occurrence and link strength among the five scientific fields, namely Artificial Intelligence 33.33%, Machine Learning 15.38%, Deep Learning 23.08%, Data Mining 12.82% and IoT 15.38%. The second-best are Google Scholar, then IEEE Xplore, and Crossref.
Evaluation of Complementary Filter Method in Increasing the Performance of Motion Tracking Gloves for Virtual Reality Games
Authors: Atoir Fairus Zuhair Azizy , Putrada Aji Gautama , Pahlevi Rizka Reza
Published: June 2021

In the use of Virtual Reality-based video games, users need additional devices to interact, one of which is a Motion Tracking Glove. The Motion Tracking Glove is one of the enhancements that users can use to interact with objects in VR video games. To get the angle value, an accelerometer sensor is used in the MPU6050 module. However, the problem that arises is the accuracy of the sensor because VR demands a low error rate. The purpose of this study is to improve the accuracy of the angular value of the accelerometer sensor value with a complementary filter. Complementary filters can increase the accuracy of the accelerometer sensor by combining its value with the gyroscope sensor value. The Motion Tracking Glove is built using the Arduino Nano and the MPU6050 module to capture angles that move according to hand movements, to connect and exchange data to the main VR device, the Motion Tracking Glove using the Bluetooth module. The results are RMSE 0.6 and MAPE 2.5% with a static Motion Tracking Glove position without movement. In sending Motion Tracking Glove data using the Bluetooth module, the resulting delay time when sending ranges from 0.1 second to 0.4 seconds by trying to move the Motion Tracking Glove from 0 degrees to 90 degrees and back to 0 degrees.
Experiment of Path Planning Using Multi-way Points with A* Algorithm for Autonomous Surface Vehicle
Authors: Erfianto Bayu , Adrianne Adysti , Arif Ramzy Rashaun
Published: June 2021

Commonly, surveillance activities on lake waters is mostly carried out by using a surface vehicle as special-designed vehicle, especially to conduct water quality measurements, underwater surveys, and bathymetry mapping. However, conventional survey and monitoring still involves humans on the site. If a survey is conducted during strong wind conditions, it could jeopardize surveyor’s safety. Therefore, a vehicle must have several criteria, e.g., it must be pretty spacious and comfortable to carry surveyors, free from engine vibrations, stabilized and easy to maneuver, and the surveyor's safety can be guaranteed. This paper discusses preliminary research aiming to develop an Autonomous Raft Vehicle (ARV), a type of autonomous unmanned surface vehicle.  The ARV is equipped with autonomous control based on multi-way-points with an A* algorithm. Thus, a user only requires giving a command once initially during path planning. A* algorithm over multi-way-point could improve ARV navigation when there are obstacles along the predetermined trajectory. Hence the predetermined trajectory will be maintained throughout the mission. It is a significant contribution to this paper.
THE STRUGGLE BETWEEN POLITICAL AND IDEOLOGICAL OVER THE IMPLEMENTATION SHARIA-NUANCED REGIONAL REGULATION
Authors: Ham Musahadi
Published: June 2021

The positivation of Sharia (Islamic law) is an important topic that remains interesting to raise when discussing the institutionalization of Sharia in Indonesia. This topic is also a significant theme in the discussions of Islamic law in other parts of the Islamic world. How to make Islamic law as legal rules that apply nationally is one of the primary agenda. The objective is clear, that is so that Islamic law is neither merely an ideal law found in the collective awareness in the community’s belief system nor an "archive" discussed to satisfy the needs of intellectual exercise in academic institutions. It should become the law that applies positively. The establishment of Law Number 1 of 1974 concerning Marriage, Law Number 7 of 1989 concerning Religious Courts, and Presidential Instruction Number 1 of 1991 concerning the compilation of Islamic laws became important milestones in the history of Islamic law in Indonesia. Since the beginning of the reform era, the implementation of Islamic Sharia entered a new phase, as marked by the flourishing of Sharia regional regulations in various regions. The emergence of the Sharia regional regulations is certainly through serious political struggles, given that the real law is a product of the political process. The regional regulations, at the same time, has been through a massive ideological struggle, because the plurality of religions and ideologies in Indonesia will be powerful energy for the emergence of pros and cons of the emergence of this regional regulation. This article will explain the political and ideological struggle around the Sharia regional regulation.
THEORETICAL REVIEW OF ISLAMIC LEGAL SOURCES ACCORDING TO THE MISREPRESENTATION THEORY OF HALLAQ
Authors: Budiman Rahmat
Published: June 2021

The existence of Islamic law from time to time in a Muslim community is believed to be the result of an in-depth study of the sources of Islamic law: the Qur’an (the Word of God), Hadith (sayings of the Prophet Muhammad), Ijtihad (the process of making a legal decision by independent interpretation of the legal sources, the Qur’an and the Sunnah), Qiyas (the deduction of legal prescriptions from the Qur’an or Sunnah by analogic reasoning), as well as Ijma (the result of the agreement of the Scholars). These sources of Islamic law were then poured into Usul al-Fiqh, which was then considered as a concrete form of Islamic law itself. This is reinforced by the classical teachings of orientalist Scholars who acknowledge that Islamic law is preserved in Usul al-Fiqh by great Scholars. However, this concept was challenged by Hallaq with a misrepresentation of his theory. He stated that Sharia can exist in society, not because of the role of Usul al-Fiqh but the role of the Fatwa (authoritative legal opinion), which is given by the Mufti and is applied by practitioners of Islamic law in Muslim-majority societies.
PRAGUE QUADRENNIAL: SPACE AND SCENE DESIGN - PART 2
Authors: Scheffler Ismael , De Araúdo José Sávio Oliveira , Muniz Rosane , Dias Massa Clóvis
Published: June 2021

Presentation of articles from issue 31 of the periodical, second part of the dossier that addresses themes around the 14th edition of the Prague Quadrennial: Space and Scene Design, 2019.
Topographies of the Obsolete
Authors:   ,   Universitetet i Bergen, Brownsword Neil , Mydland Anne Helen
Published: June 2021

Topographies of the Obsolete is an artistic research project initiated by Professors Neil Brownsword and Anne Helen Mydland at Bergen Academy of Art and Design (KHiB) in collaboration with partner universities/institutions in Denmark, Germany, Switzerland, France and the UK. In 2012 the British Ceramics Biennial invited Bergen Academy of Art and Design (KHiB) to develop a site-specific artistic response to the former Spode Factory in Stoke-on-Trent as a key element of their 2013 exhibition programme. The project explores the landscape and associated histories of post-industry, with an initial emphasis on Stoke-on-Trent, a world-renowned ceramics capital that bears evidence of fluctuations in global fortunes.
Favipiravir Use in Kidney Transplant Recipients with Covid 19: A Single Center Experience
Authors: Kaya Burcu , Atas Dilek Barutcu , Tükenmez Elif Tigen , Asicioglu Ebru , Arikan Hakki , Tuglular Serhan , Velioglu Arzu
Published: June 2021

Aim: Kidney transplant patients are amongst the high-risk groups for
severe Covid 19. To date, no specific antiviral agent has been found
uniformly effective against severe acute respiratory syndrome
coronavirus 2 (SARS-CoV2). Favipiravir, the recommended drug by The
Turkish Ministry of Health, was uniformly supplied to all patients
diagnosed to have COVID 19 with a positive nasopharyngeal swap PCR test.
The aim of our study was to retrospectively compare our kidney
transplant recipients who developed COVID-19 infection started on
Favipiravir to those who did not use Favipiravir for the clinical course
of the disease with a special emphasis on the occurrence of side
effects/adverse events. Methods: Thirty-seven consecutive KT recipients
with a median age of 46 years and of whom 62.2% were women; 8 deceased
/29 living related donor, with a 8.0 (5.5-12.5) years median duration of
transplantation were included in the study. Results: Twenty-six (70.3%)
patients received Favipiravir, 11(29.7%) did not. There was no
statistical significance in baseline demographic, clinical and
laboratory findings between the groups except that the Favipiravir group
was older and had a higher requirement of oxygen treatment. There was no
statistically significant difference in the course and outcome of
COVID-19 infection, in the occurrence of side effects/adverse events
related to Favipiravir between the two groups. Laboratory data at
baseline, day7 and 30 were also comparable between the groups.
Conclusion: Although the efficacy of Favipiravir in the treatment of
COVID-19 infection is currently controversial, Favipiravir can safely be
used in kidney transplant patients.
Blow-up Versus Global Well-posedness for the focusing INLS with inverse-square potential
Authors: Deng Mingming , Lu Jing , Meng Fanfei
Published: June 2021

We study the focusing inhomogeneous nonlinear
Schr\”odinger equation with inverse-square potential
$$ i\partial_tu+\Delta
u-\frac{a}{|x|^2}u+|x|^{-b}|u|^{2}u=0,
$$ where $a>-\frac14$ and $0
Olfactory training assists in olfactory recovery after sinonasal surgery
Authors: Park Joon Yong , Lee Jiyeon , Kim Hansol , Jung Taesik , Kim Jin Kook
Published: June 2021

Abstract Objectives: In patients with chronic rhinosinusitis (CRS),
olfactory dysfunction (OD) is a common complaint. The focus of this
research was to evaluate the effectiveness of olfactory training (OT) in
patients with CRS after sinonasal surgery. Design : Prospective
controlled trial. Participants: We enrolled 111 Korean CRS patients who
underwent sinonasal surgery. Main Outcome Measures: At baseline and
three months after starting OT, both participants were assessed by an
olfactory function test and endoscopy. The Korean version of the
Sniffin’ stick II (KVSS-II) was used to perform the olfactory function
test. A visual analog scale and the Mini-Mental State Examination were
used to assess nasal and psychological functions. Over the course of
three months, five odorants were used in OT (rose, lemon, cinnamon,
orange, and peach). Results: Over a 12-week duration, OT increased
olfactory activity in nearly 62 percent of subjects than in non-OT
subjects. The OT group had significantly higher olfactory outcomes for
the total KVSS-II and identification scores than the non-OT group
between the initial and follow-up assessments. The initial score
influenced the degree of olfactory improvement after OT. Conclusions: OT
patients exhibited significantly higher total KVSS-II scores compared
with non-OT patients after sinonasal surgery; in particular, the odor
identification score was different between the two groups. The results
of this study show that a 12-week period of repeated short-term exposure
to various odors could be useful in enhancing olfactory activity in
patients who underwent sinonasal surgery for the improvement of
sensory-neural olfactory impairment.
Intraoperative Hyperoxygenation May Negatively Affect Postoperative Cognitive Functions in Coronary Artery Bypass Graft Operations: A Randomized Controlled Study
Authors: ONUR TUĞBA , Karaca Ümran , Ata Filiz , Sayan Halil , Onur Anıl , Yılmaz Canan , Balkaya Ayşe , Eris Cuneyt
Published: June 2021

Objective: In this study, it was aimed to compare various parameters
during surgery and postoperative cognitive functions in patients
undergoing coronary artery bypass graft (CABG) surgery using different
levels of perioperative oxygen. Methods: One hundred patients scheduled
for elective CABG surgery were included in the study. The patients were
divided into two groups according to arterial oxygen levels during
surgery. In the normoxia group (NG) (n = 50), PaO2 was between ≥100mmHg
and <180mmHg with at least 40% FiO2 mechanical ventilation
(MV), and in the hyperoxia group (HG) (n = 50), PaO2 was ≥180 mmHg with
100% FiO2 MV. Hemodynamic parameters, peripheral oxygen saturation
(SpO2), cerebral oxygen saturation (rSO2) measured from bilateral
sensors, and blood gas values were recorded at the planned measurement
times. Mini-mental state examination test (MMSE) was applied to the
patients before and at the 12th, 24th hours; on the 1st, 3rd, 6th months
after surgery. Results: Extubation time was found to be shorter in NG (p
<0.05). Between the groups, rSO2 and mean arterial pressure
(MAP) were found to be significantly lower in HG at the time of T4
measurement (p = 0.042, p = 0.038, respectively). MMSE values of the
groups at the 1st, 3rd and 6th months were found to be significantly
higher in NG (respectively p = 0.017, p = 0.014, p = 0.002). Conclusion:
Hyperoxemia application during CABG may be associated with worse
postoperative late-term cognitive functions. Keywords: cardiopulmonary
bypass; hyperoxia; postoperative complications; cognitive function;
spectroscopy, near-infrared.
An adaptable microreactor to investigate the influence of interfaces on biofilm development of Pseudomonas aeruginosa
Authors: zhang Ye , Silva Dina , Traini Daniela , Yound Paul , Cheng Shaokoon , Ong Huixin
Published: June 2021

Biofilms are ubiquitous and notoriously difficult to eradicate and
control, complicating human infections, industrial and agricultural
biofouling. Current biofilm studies are commonly performed with the
biofilm cultured on mono-interface and generally have neglected to
consider more realistic biofilm, where diverse interfaces are involved.
In our study, a reusable dual-chamber microreactor with interchangeable
membranes was developed to establish multiple interfaces for biofilm
culture and test. Protocol for culturing Pseudomonas aeruginosa (PAO1)
on the air-liquid interface (ALI) and liquid-liquid interface (LLI)
under static environmental conditions for 48h was optimized using this
novel device. This study shows that LLI model biofilms are more
susceptible to physical disruption compared to ALI model biofilm. SEM
images revealed a unique ‘mushroom-shaped’ microcolonies morphological
feature, which is more distinct on ALI biofilms than LLI. Furthermore,
the study showed that ALI and LLI biofilms produced a similar amount of
extracellular polymeric substances (EPS). As differences in biofilm
structure and properties may lead to different outcomes when using the
same eradication approaches, the antimicrobial effect of an antibiotic,
Ciprofloxacin (CIP), was chosen to test the susceptibility of 48h-old
ALI and LLI biofilms. Our results show that the minimum eradication
concentration (MBCE) of CIP using our dual-chamber device reached
1600μg/ml, which is significantly higher than the conventional
microtiter plate method (64μg/ml). The results highlight the importance
of having a model that can closely mimic in-vivo conditions to develop
more effective biofilm management strategies.
Epidermoid Cyst of the Buccal Mucosa: An Uncommon Entity. Case report and literature review
Authors: dammak nouha , chokri abdellatif , slim afef , Bellalah Ahlem , Bouguezzi Adel , sioud sameh , hentati hajer , selmi jamil
Published: June 2021

Epidermoid, dermoid and teratoid cysts are nonodontogenic benign lesions
derived from the germinative epithelium, appearing any where of the
body. In the oral cavity, these are uncommon and account for less than
0.01% of all the oral cysts. These cysts often remain asymptomatic for
years however can become acutely symptomatic.
Physical activity in asthma control and its immune modulatory effect in asthmatic preschoolers
Authors: Maurer Debbie , Liu Chengyao , XEPAPADAKI PARASKEVI , Bachert Claus , Finotto Susetta , Gao Ya-dong , Graser Anna , Jartti Tuomas , Kistler Walter , Kowalski Marek , Lukkarinen Heikki , Passioti Maria , Stanic Barbara , Tan Ge , Villiger Michael , Zhang Luo , Zhang Nan , Akdis Mübeccel , Papadopoulos Nikolaos , Akdis Cezmi
Published: June 2021

Background: The impact of physical activity (PA) on immune response is a
hot topic in exercise immunology, but studies involving asthmatic
children are scarce. We examine the level of PA and TV attendance (TVA)
in asthmatic children to assess the role on asthma control and immune
response to various stimulants. Methods: Weekly PA and daily TVA were
obtained from questionnaires at inclusion of the PreDicta study. PBMC
cultures were stimulated with phytohemagglutinin (PHA), R848, poly I:C
and zymosan. Cytokines were measured and quantified in cell culture
supernatants using luminometric multiplex immunofluorescence beads-based
assay. Results: Asthmatic preschoolers showed significantly more TVA
than their healthy peers (58.6% vs. 41.5% 1-3h daily and only 25.7%
vs. 47.2% ≤ 1h daily). Poor asthma control was associated with less
frequent PA (75% no or occasional activity in uncontrolled vs. 20% in
controlled asthma; 25% ≥ 3x weekly vs. 62%). Asthmatics with increased
PA exhibited elevated cytokine levels in response to stimulants,
suggesting a readiness of circulating immune cells for type-1, -2 and
-17 cytokine release compared to low-PA and high-TVA subjects. Low PA
and high TVA were associated with increased proinflammatory cytokines.
Proinflammatory cytokines were correlating with each other in in-vitro
immune responses of asthmatic children, but not healthy controls.
Conclusion: Asthmatic children show more sedentary behavior than healthy
subjects, while poor asthma control leads to a decrease in PA. Asthmatic
children profit from exercise, as elevated cytokine levels in stimulated
conditions indicate an immune system prepared for a strong response in
case of infection.