bluuebunny/crossref_metadata_2025 huggingface dataset:
The Latest Data Specifically Focused on Long-Term Oncologic Prognostication for Very Old Adults with Acute Vulnerable Localized Prostate Cancer: A Nationwide Cohort Study
Authors: Wu Szu-Yuan , Effendi Fransisca Fortunata , Canales Ricardo E. , Huang Chung-Chien
Published: June 2022

Purpose: Few studies have evaluated the prime treatment choice for men older than 80 years with acute vulnerable localized prostate cancer (AV-LPC). Clinicians have been deeply troubled by this near end-of-life medical choice for a very specific group of patients. We compared the oncological prognostication of very old patients with AV-LPC after they underwent either radical prostatectomy (RP) or massive-dose intensity-modulated radiotherapy (IMRT) coupled with long-term androgen deprivation therapy (ADT) over a long-term investigation. Methods: In this nationwide cohort study, we used the Taiwan Cancer Registry Database and retrieved information related to patients (aged ≥ 80 years) with AV-LPC who underwent standard RP (the RP group) or massive-dose IMRT + long-term ADT (at least 72 Gy and ADT use ≥18 months; the IMRT + ADT group). After potential confounders were controlled for using propensity score matching (PSM), we utilized the Cox proportional hazards regression to evaluate the oncologic prognostication. Results: The IMRT + ADT group had a significantly higher adjusted hazard ratio (aHR) for all-cause mortality (aHR, 2.00; 95% confidence interval [CI], 1.41–2.87) than the RP group. Analysis of the secondary outcomes revealed that compared with the RP group, the aHRs of biochemical failure, locoregional recurrence, and distant metastasis in the IMRT + ADT group were 1.77 (95% CI: 1.36–2.11, p < 0.0001), 1.12 (95% CI: 1.04–1.33, p < 0.0001), and 1.15 (95% CI: 1.06–1.71, p = 0.0311), respectively. Conclusion: RP provides more favorable oncological prognostication than IMRT in very old adults with AV-LPC.
Maternal Race and Stillbirth: Cohort Study and Systematic Review with Meta-Analysis
Authors: Arechvo Anastasija , Nikolaidi Despoina A. , Gil María M. , Rolle Valeria , Syngelaki Argyro , Akolekar Ranjit , Nicolaides Kypros H.
Published: June 2022

Accurate identification of independent predictors of stillbirth is needed to define preventive strategies. We aim to examine the independent contribution of maternal race in the risk of stillbirth after adjusting for maternal characteristics and medical history. There are two components to the study: first, prospective screening in 168,966 women with singleton pregnancies coordinated by the Fetal Medicine Foundation (FMF) and second, a systematic review and meta-analysis of studies reporting on race and stillbirth. In the FMF study, logistic regression analysis found that in black women, the risk of stillbirth, after adjustment for confounders, was higher than in white women (odds ratio 1.78, 95% confidence interval 1.50 to 2.11). The risk for other racial groups was not significantly different. The literature search identified 20 studies that provided data on over 6,500,000 pregnancies, but only 10 studies provided risks adjusted for some maternal characteristics; consequently, the majority of these studies did not provide accurate contribution of different racial groups to the prediction of stillbirth. It is concluded that in women of black origin, the risk of stillbirth, after adjustment for confounders, is about twofold higher than in white women. Consequently, closer surveillance should be granted for these women.
The Patho-Neurophysiological Basis and Treatment of Focal Laryngeal Dystonia: A Narrative Review and Two Case Reports Applying TMS over the Laryngeal Motor Cortex
Authors: Rogić Vidaković Maja , Gunjača Ivana , Bukić Josipa , Košta Vana , Šoda Joško , Konstantinović Ivan , Bošković Braco , Bilić Irena , Režić Mužinić Nikolina
Published: June 2022

Focal laryngeal dystonia (LD) is a rare, idiopathic disease affecting the laryngeal musculature with an unknown cause and clinically presented as adductor LD or rarely as abductor LD. The most effective treatment options include the injection of botulinum toxin (BoNT) into the affected laryngeal muscle. The aim of this narrative review is to summarize the patho-neuro-physiological and genetic background of LD, as well as the standard recommended therapy (BoNT) and pharmacological treatment options, and to discuss possible treatment perspectives using neuro-modulation techniques such as repetitive transcranial magnetic stimulation (rTMS) and vibrotactile stimulation. The review will present two LD cases, patients with adductor and abductor LD, standard diagnostic procedure, treatments and achievement, and the results of cortical excitability mapping the primary motor cortex for the representation of the laryngeal muscles in the assessment of corticospinal and corticobulbar excitability.
An Accuracy-Maximization Approach for Claims Classifiers in Document Content Analytics for Cybersecurity
Authors: Ameri Kimia , Hempel Michael , Sharif Hamid , Lopez Jr. Juan , Perumalla Kalyan
Published: June 2022

This paper presents our research approach and findings towards maximizing the accuracy of our classifier of feature claims for cybersecurity literature analytics, and introduces the resulting model ClaimsBERT. Its architecture, after extensive evaluations of different approaches, introduces a feature map concatenated with a Bidirectional Encoder Representation from Transformers (BERT) model. We discuss deployment of this new concept and the research insights that resulted in the selection of Convolution Neural Networks for its feature mapping aspects. We also present our results showing ClaimsBERT to outperform all other evaluated approaches. This new claims classifier represents an essential processing stage within our vetting framework aiming to improve the cybersecurity of industrial control systems (ICS). Furthermore, in order to maximize the accuracy of our new ClaimsBERT classifier, we propose an approach for optimal architecture selection and determination of optimized hyperparameters, in particular the best learning rate, number of convolutions, filter sizes, activation function, the number of dense layers, as well as the number of neurons and the drop-out rate for each layer. Fine-tuning these hyperparameters within our model led to an increase in classification accuracy from 76% obtained with BertForSequenceClassification’s original model to a 97% accuracy obtained with ClaimsBERT.
The Rise of Polymeric Microneedles: Recent Developments, Advances, Challenges, and Applications with Regard to Transdermal Drug Delivery
Authors: Gera Aswani Kumar , Burra Rajesh Kumar
Published: June 2022

The current scenario of the quest for microneedles (MNs) with biodegradability and biocompatibility properties is a potential research area of interest. Microneedles are considered to be robust, can penetrate the skin’s deep-seated layers, and are easy to manufacture, and their applications from the clinical perspective are still ongoing with standard escalation. This review paper focuses on some of the pivotal variants of polymeric microneedles which are specifically dissolvable and swell-based MNs. It further explores the drug dissolution kinetics and insertion behavior mechanisms with an emphasis on the need for mathematical modeling of MNs. This review further evaluates the multifarious fabrication methods, with an update on the advances in the fabrication of polymeric MNs, the choice of materials used for the fabrication, the challenges in polymeric MN fabrication, and the prospects of polymeric MNs with applications pertinent to healthcare, by exclusively focusing on the procurable literature over the last decade.
Research on AUV Energy Saving 3D Path Planning with Mobility Constraints
Authors: Zhang Guocheng , Liu Jixiao , Sun Yushan , Ran Xiangrui , Chai Puxin
Published: June 2022

This paper aims to focus on the path planning problem of AUV in the marine environment. As well as considering the path length and safe obstacle avoidance, ocean currents should not be ignored as the main factor affecting the navigation energy consumption of AUV. At the same time, the path should satisfy the mobility constraint of AUV; otherwise, the path is inaccessible to AUV. For the above problems, this paper presents a path planning algorithm based on an improved particle swarm (EPA-PSO); the fitness function is designed based on path length, energy consumption, and mobility constraints. The updated law of particle velocity and the initialization law of particles are improved, and the possible optimal solutions are stored in the feasible solution set; finally, the optimal solutions are obtained by comparison. The local jumping ability is given to the particle swarm so that the particles can jump out of the local optimal solution. The path planning simulation experiment is compared with the traditional PSO algorithm. The results show that the EPA-PSO algorithm proposed in this paper can be used in the AUV three-dimensional path planning process. It can effectively save energy and make the navigation path of AUV satisfy the requirements of maneuverability. The field experiment was completed in Shanghai, China, and the experiment proved that it was feasible to obtain a path satisfying the maneuverability constraints with optimal energy consumption for the problems studied in this paper.
On Average Losses of Low-Frequency Sound in a Two-Dimensional Shallow-Water Random Waveguide
Authors: Gulin Oleg E. , Yaroshchuk Igor O.
Published: June 2022

For a low-frequency sound signal propagating in a two-dimensionally inhomogeneous shallow-water waveguide, the influence of random bathymetry (fluctuating bottom boundary) was considered based on the local-mode approach and statistical modeling using first-order evolution equations. The study was carried out in shallow sea conditions corresponding to the coastal waveguides of the Russian Arctic seas. Here, a feature was the presence of an almost homogeneous water layer with various characteristics of seabed sediments. To describe the latter, a random model of the impedance was adopted. For the conditions of a strongly penetrable bottom boundary, on average, the calculations predicted adequate weak effects of bathymetry fluctuations on the average sound intensity compared to the effect of fluctuations in the sediment parameters and volumetric random inhomogeneities of the water column. In addition, it was shown that, in terms of statistics, the roughness of the bottom boundary perturbed the average sound intensity in a shallow-water waveguide differently than volumetric fluctuations in the speed of sound. The dependence of the statistical effects (the first and second moments of the signal intensity) on the parameters of the waveguide and the frequency range was studied. As a result of numerical modeling, comparative quantitative estimates of the influence of both the random roughness of the bottom interface and fluctuations of bottom sediment parameters on the average losses of the propagating signal, not presented in the literature, were obtained.
Coenzyme Q10 and Parkinsonian Syndromes: A Systematic Review
Authors: Jiménez-Jiménez Félix Javier , Alonso-Navarro Hortensia , García-Martín Elena , Agúndez José A. G.
Published: June 2022

Coenzyme Q10 (CoQ10) has an important role as an antioxidant. Being that oxidative stress is one of the mechanisms involved in the pathogenesis of Parkinson’s disease (PD) and other neurodegenerative diseases, several studies addressed the concentrations of CoQ10 in the different tissues of patients with PD and other parkinsonian syndromes (PS), trying to elucidate their value as a marker of these diseases. Other studies addressed the potential therapeutic role of CoQ10 in PD and PS. We underwent a systematic review and a meta-analysis of studies measuring tissue CoQ10 concentrations which shows that, compared with controls, PD patients have decreased CoQ10 levels in the cerebellar cortex, platelets, and lymphocytes, increased total and oxidized CoQ10 levels in the cerebrospinal fluid and a non-significant trend toward decreased serum/plasma CoQ10 levels. Patients with multiple system atrophy (MSA) showed decreased CoQ10 levels in the cerebellar cortex, serum/plasma, cerebrospinal fluid, and skin fibroblasts. Patients with Lewy body dementia (LBD) showed decreased cerebellar cortex CoQ10, and those with progressive supranuclear palsy (PSP) had decreased CoQ10 levels in the cerebrospinal fluid. A previous meta-analysis of studies addressing the therapeutic effects of CoQ10 in PD showed a lack of improvement in patients with early PD. Results of the treatment with CoQ10 in PSP should be considered preliminary. The potential role of CoQ10 therapy in the MSA and selected groups of PD patients deserves future studies.
Biological Therapy of Severe Asthma and Nasal Polyps
Authors: Bakakos Agamemnon , Schleich Florence , Bakakos Petros
Published: June 2022

Chronic rhinosinusitis is a common disease worldwide and can be categorized into chronic rhinosinusitis with nasal polyps and chronic rhinosinusitis without nasal polyps. Chronic rhinosinusitis with nasal polyps is common in patients with asthma and, particularly, severe asthma. Severe asthma is effectively treated with biologics and the coexistence of severe asthma with chronic rhinosinusitis with nasal polyps presents a phenotype that is more likely to respond to such treatment. In this review, we focus on the link between asthma and nasal polyps, and we review the treatment effect of various monoclonal antibodies in patients with severe asthma and nasal polyps as well as in patients with nasal polyps without asthma or with mild-to-moderate asthma. With the enhancement of our armamentarium with new monoclonal antibodies the right choice of biologic becomes an important target and one that is difficult to achieve due to the lack of comparative head-to-head studies.
A Knowledge Map Study of an Application of a Smart Land Planning Free-Trade Zone and China’s Contribution
Authors: Ye Penghao , Zhang Huarong , Ma Siyi , Yang Fang , Li Yanan
Published: June 2022

The use of a free-trade zone (FTZ) has emerged as a smart land tool in increasing trading, attracting foreign investment, attempting financial openness and conducting other pilot economic reforms, which adds higher requirements for smart spatial planning, smart industry planning and smart management planning. However, no systematic analysis has been performed, making it difficult to provide deeper insights into FTZs. Thus, this study conducted bibliometric and visual analysis to identify the research status, new theories or practices, and potential future directions of FTZs based on 953 publications from the Web of Science Core Collection. The results show that there is a marked rise in the number of FTZ studies since 2013, which is the same year China authorized the first FTZ in Shanghai. China and the United States of America have played a leading role in FTZ research. Finally, the increasing trend in FTZ utilization will remain sizeable during its deepening development. The findings may contribute to a better understanding of FTZs and make some references to smart land-use planning experience and practices around the globe.
Performance and Obstacle Tracking to Qilian Mountains’ Ecological Resettlement Project: A Case Study on the Theory of Public Value
Authors: Wang Ya , Zhou Lihua
Published: June 2022

In Gansu Province, China, Wuwei City is an ecologically fragile migration area at the intersection of the Loess Plateau, the Qinghai-Tibet Plateau, and the Mongolia-New Plateau. Using the Triangular Fuzzy TOPSIS method and the obstacle factor diagnostic model, the implementation performance and follow-up support issues of the Ecological Resettlement Project were analyzed from the perspective of the eco-migrant and the public value theory. In contrast to traditional performance appraisal methods, Triangular Fuzzy TOPSIS breaks through the ambiguity of complex environments and subjective information and effectively quantifies the fuzziness of evaluator language variables to improve the validity. The overall performance of the Ecological Resettlement Project in Wuwei is good; the average closeness degree of process is higher than outcome. Migrants rated the fairness of the project as the highest, followed by support, economic outcome, and satisfaction. Gulang County’s performance in the Ecological Resettlement Project is the best, followed by Tianzhu County and Liangzhou District. Project obstacles were mostly related to the outcome dimension, especially the ecological restoration and management, the return to poverty risk, and industrial development on the resettlement site. The main obstacle to the process dimension is migrant satisfaction with government subsidies. Research results provide case study support and experience inspiration for migrant relocation models and their long-term livelihood improvement in the context of rural revitalization.
Insect Outbreak and Long-Term Post-Fire Effects on Soil Erosion in Mediterranean Suburban Forest
Authors: Kastridis Aristeidis , Stathis Dimitrios , Sapountzis Marios , Theodosiou Georgios
Published: June 2022

Our study was conducted in the suburban forest of Thessaloniki (Seich Sou), which constitutes one of the most significant suburban forests of Greece and is located northeast of Thessaloniki. In 1997, more than the half of the forest area was destroyed by a wildfire, while recently (May 2019), a significant insect outbreak by the bark beetle Tomicus piniperda was detected. The insect action still goes on, while the infestation has destroyed so far more than 300 ha of forest area. Extensive selective logging and removal of infected trees from the forest were carried out in order to mitigate and restrict the outbreak spread. In the current study, silt-fenced erosion plots were installed on representative locations of disturbed (by fire and insect action) and undisturbed areas, in order to quantify the effect of the above-mentioned forest disturbances on soil erosion and correlate the height and intensity of precipitation with the soil erosion rate. The results show that there was no statistically significant increase in soil erosion in the areas of insect outbreak compared with the control plots. However, there was a statistically significant increase in soil erosion in areas where logging works had been applied as an infestation preventive measure. In addition, the study revealed that 25 years after the forest fire, the erosion rate is still at higher level compared with the undisturbed forest areas. This study could be considered as one of the first attempts to evaluate the impact of an insect outbreak infestation on soil erosion, while there is also a great lack of information concerning the assessment of long-term post-fire effects on the soil erosion of a forest ecosystem.
A Heuristic Method to Evaluate the Effect of Soil Tillage on Slope Stability: A Pilot Case in Central Italy
Authors: Volpe Evelina , Gariano Stefano Luigi , Ardizzone Francesca , Fiorucci Federica , Salciarini Diana
Published: June 2022

Among the various predisposing factors of rainfall-induced shallow landslides, land use is constantly evolving, being linked to human activities. Between different land uses, improper agricultural practices can have a negative impact on slope stability. Indeed, unsustainable soil tillage can modify the mechanical properties of the soils, leading to a possible increase of the instability phenomena. However, the effects of soil tillage on slope stability are poorly investigated. To address this topic, the PG_TRIGRS model (a probabilistic, geostatistic-based extension of TRIGRS) was applied to a cultivated, landslide-prone area in central Italy, thoroughly studied and periodically monitored through systematic image analysis and field surveys. A heuristic approach was adopted to quantitatively evaluate the effect of soil tillage on the mechanical properties of the soil: after a first run of the model with unbiased parameters, the slope stability analysis was carried out assuming several percentages of reduction of the effective soil cohesion to mimic an increasing impact of soil tillage on the strength conditions. Then, a comparison between observed landslides and the spatial distribution of the probability of failure derived from the application of PG_TRIGRS was carried out. A back analysis with contingency matrix and skill scores was adopted to search for the best compromise between correct and incorrect model outcomes. The results show that soil tillage caused a 20 to 30% reduction in soil cohesion in the analyzed area.
Rediscovering the Scaling Law of Urban Land from a Multi-Scale Perspective—A Case Study of Wuhan
Authors: He Qingsong , Huang Lingping , Li Jing
Published: June 2022

The law of urban scaling implies that there is a universally applicable nonlinear scaling relationship between population size and urban indicators, which is a method of quantitative analysis that can reflect the growth law and internal logic of the urban system. However, most present research is conducted at the municipal scale, and studies of scaling law in the inner-city system are scarce, especially from the perspective of compact urban form development. The goal of this paper is to discover the scaling law within urban systems from a multi-scale perspective. Through the empirical analysis of Wuhan, this paper examines the internal scale law of the urban system from the municipal and district scales. Moreover, we use the landscape expansion index to perform spatial autocorrelation analysis. In this way, we assess the relationship between the compactness of urban morphological development and the urban scaling law. The results indicate that the temporal scaling law on the city scale has a more significant linear law than the single-year scaling law. The analysis also shows the scaling law relationship within the inner-city system. Nevertheless, there is a deviation between the temporal scaling law and the cross-section scaling law. Namely, the time series development of a district does not follow the section scaling law of the urban system. Furthermore, the urban scaling law shows a negative correlation with the compactness of the urban form development. It is crucial to understand the current economic development and resource endowment of an urban system in the urbanization process, as it significantly contributes to urban development and regional coordinated planning.
The Impacts of Regional Cooperation on Urban Land-Use Efficiency: Evidence from the Yangtze River Delta, China
Authors: Pan Lisha , Hu Hangang , Jing Xin , Chen Yang , Li Guan , Xu Zhongguo , Zhuo Yuefei , Wang Xueqi
Published: June 2022

Urban land-use efficiency (ULUE) has been increasingly recognized as an issue of land-use management across the world in the last century as the globe experienced unprecedented rapid urban expansion. However, although a large body of studies was dedicated to analyzing the driving forces of ULUE, literature was rarely focused on the impacts of regional cooperation on ULUE. To bridge the knowledge gap, we used the Chinese trailblazer of regional cooperation–Yangtze River delta (YRD)—as a case to reveal the impacts of regional cooperation on ULUE. Social network analysis and a super efficiency SBM model with undesirable outputs were used to measure regional cooperation and ULUE, respectively. Furthermore, the impacts of regional cooperation on ULUE were examined by using the geographically and temporally weighted regression model. The results show that regional cooperation in the YRD strengthened from 2009 to 2016, among which Shanghai was the core node city in the YRD. Only seven cities maintained good ULUE with a stable trend during 2009–2016. The regression results indicated the positive impacts of regional cooperation on ULUE, which was more evident in the southern cities of the YRD. The potential mechanism to explain the impacts of regional cooperation on ULUE includes co-building transportation facilities and joint development zones. These findings provide insightful implications for improving ULUE by strengthening regional cooperation in Chinese cities.
Morphometric Analysis of Scoria Cones to Define the ‘Volcano-Type’ of the Campo de Calatrava Volcanic Region (Central Spain)
Authors: Becerra-Ramírez Rafael , Dóniz-Páez Javier , González Elena
Published: June 2022

The Campo de Calatrava Volcanic Region is the largest volcanic field in the Iberian Peninsula and presents a complex volcanic history, with more than 360 monogenetic basaltic volcanoes developed in effusive, Strombolian, and hydromagmatic eruptions. The large number of scoria cones, compared to the other existing types of volcanic morphologies, indicates that these landforms represent the most common eruptive events that occurred during Calatrava’s geological past. In this work, a morphometric analysis of the scoria cones was carried out, based on statistical analysis of the main morphological parameters of these volcanoes (height, cone width, crater width, crater depth, slope, area, etc.). The results were used to identify the most frequent scoria cone by means of statistical analysis of its main morphological features. To do this, a methodology based on statistical correlations of the morphological and morphometric parameters that best define the morphology of these volcanoes was applied. The number of cones and their distribution correspond to platform volcanic fields. The most frequent identified monogenetic volcano corresponds to a scoria cone developed in Strombolian dynamics with lava flows, with mean dimensions of 36.54 m height, 0.008113 km3 volume and an area of 0.454 km2.
Comparing Community Needs and REDD+ Activities for Capacity Building and Forest Protection in the Équateur Province of the Democratic Republic of Congo
Authors: Morgan Edward A. , Bush Glenn , Mandea Joseph Zambo , Kermarc Melaine , Mackey Brendan
Published: June 2022

Primary forests are essential ecosystems that can play a key role in mitigating climate change. REDD+ is designed to help countries and communities secure benefits for avoiding deforestation but has faced significant implementation challenges. There are substantial potential benefits for REDD+ in the Democratic Republic of Congo (DRC), where shifting agriculture is the major cause of deforestation. However, implementation requires significant capacity building in a number of sectors and at a number of levels. This paper explores how well the capacity building activities within the DRC REDD+ strategy are aligned with the capacity needs identified by provincial government stakeholders and local communities in the Équateur province of the DRC, identified through workshops and surveys. The research suggests that while many technical capacity needs identified by stakeholders could be potentially addressed by the REDD+ strategy, there are number of systemic capacity needs that are unlikely to be addressed. Failure to address these needs risks undermining any implementation of REDD+. The results suggest that education and training in governance and management, as well as fundamental education in sustainability, are key capacity needs that REDD+ may need to incorporate. The results also provide further evidence that REDD+ projects need to be long-term and take into account the local context and needs in order to be effective.
Coupling Coordination Development of New-Type Urbanization and Cultivated Land Low-Carbon Utilization in the Yangtze River Delta, China
Authors: Zhang Yue , Dai Yaqiang , Chen Yuanyuan , Ke Xinli
Published: June 2022

Although urbanization greatly benefits economy-society development in China, it poses enormous challenges to cultivated land utilization. In the context of urbanization acceleration and carbon neutrality, it’s of significance to achieve high-quality economy-society development and sustainable agricultural development. Thus, the coupling coordination relationship between new-type urbanization and cultivated land low-carbon utilization (CLLCU) needs to be examined. However, this topic has not been adequately addressed in previous studies. To fill the gap, this paper adopted a comprehensive evaluation model and a super-efficiency SBM (Slacked Based Measure) model to evaluate the level of new-type urbanization and the cultivated land low-carbon utilization efficiency (CLLCUE) of cities in the Yangtze River Delta in China from 2000 to 2018. Furthermore, the coupling coordination degree model (CCDM) and the relative development degree model (RDDM) were employed to measure the coupling coordination degree and the relative state of the new-type urbanization and CLLCU The results show that the coupling coordination degree between the new-type urbanization level and CLLCUE experienced a process of “rapid increase-steady develop” and presented a spatial pattern of “polarization-regional equilibrium”. In addition, the relative state of the new-type urbanization and CLLCU presented the “reversal” phenomenon. In other words, the relative state changed from the new-type urbanization lagging behind CLLCU to the new-type urbanization ahead of CLLCU. None of the cities were in the state of simultaneous development. Finally, this paper puts forward policy recommendations to explore differentiated CLLCU modes and improve the quality and efficiency of new-type urbanization.
Anti-Inflammatory, Antioxidant, and Anti-Atherosclerotic Effects of Natural Supplements on Patients with FMF-Related AA Amyloidosis: A Non-Randomized 24-Week Open-Label Interventional Study
Authors: Romano Micol , Garcia-Bournissen Facundo , Piskin David , Rodoplu Ulkumen , Piskin Lizzy , Elzagallaai Abdelbaset , Tuncer Tunc , Sezer Siren , Ucuncuoglu Didar , Honca Tevfik , Poddighe Dimitri , Yavuz Izzet , Stenvinkel Peter , Yilmaz Mahmut , Demirkaya Erkan
Published: June 2022

We aimed to evaluate the effect of a combination of natural products on parameters related to inflammation, endothelial dysfunction, and oxidative stress in a cohort of familial Mediterranean fever (FMF) patients with Serum Amyloid A amyloidosis, in a non-randomized, 24-week open-label interventional study. Morinda citrifolia (anti-atherosclerotic-AAL), omega-3 (anti-inflammatory-AIC), and extract with Alaskan blueberry (antioxidant-AOL) were given to patients with FMF-related biopsy-proven AA amyloidosis. Patients were >18 years and had proteinuria (>3500 mg/day) but a normal estimated glomerular filtration rate (eGFR). Arterial flow-mediated dilatation (FMD), carotid intima media thickness (CIMT), and serum biomarkers asymmetric dimethylarginine (ADMA), high sensitivity C-reactive protein (hs-CRP), pentraxin (PTX3), malondialdehyde (MDA), Cu/Zn-superoxide dismutase (Cu/Zn-SOD), and glutathione peroxidase (GSH-Px) were studied at baseline and after 24 weeks of treatment. A total of 67 FMF-related amyloidosis patients (52 male (77.6%); median age 36 years (range 21–66)) were enrolled. At the end of a 24-week treatment period with AAL, AIC, and AOL combination therapy, ADMA, MDA, PTX3, hsCRP, cholesterol, and proteinuria were significantly decreased compared to baseline, while CuZn-SOD, GSH-Px, and FMD levels were significantly increased. Changes in inflammatory markers PTX3, and hsCRP were negatively correlated with FMD change, and positively correlated with decreases in proteinuria, ADMA, MDA, cholesterol, and CIMT. Treatment with AAL, AIC and AOL combination for 24 weeks were significantly associated with reduction in inflammatory markers, improved endothelial functions, and oxidative state. Efficient control of these three mechanisms can have long term cardiovascular and renal benefits for patients with AA amyloidosis.
Multidrug Resistance of Cancer Cells and the Vital Role of P-Glycoprotein
Authors: Karthika Chenmala , Sureshkumar Raman , Zehravi Mehrukh , Akter Rokeya , Ali Faraat , Ramproshad Sarker , Mondal Banani , Tagde Priti , Ahmed Zubair , Khan Farhat S. , Rahman Md. Habibur , Cavalu Simona
Published: June 2022

P-glycoprotein (P-gp) is a major factor in the multidrug resistance phenotype in cancer cells. P-gp is a protein that regulates the ATP-dependent efflux of a wide range of anticancer medicines and confers resistance. Due to its wide specificity, several attempts have been made to block the action of P-gp to restore the efficacy of anticancer drugs. The major goal has been to create molecules that either compete with anticancer medicines for transport or function as a direct P-gp inhibitor. Despite significant in vitro success, there are presently no drugs available in the clinic that can “block” P-gp–mediated resistance. Toxicity, unfavourable pharmacological interactions, and a variety of pharmacokinetic difficulties might all be the reason for the failure. On the other hand, P-gp has a significant effect in the body. It protects the vital organs from the entry of foreign bodies and other toxic chemicals. Hence, the inhibitors of P-gp should not hinder its action in the normal cells. To develop an effective inhibitor of P-gp, thorough background knowledge is needed in this field. The main aim of this review article was to set forth the merits and demerits of the action of P-gp on cancer cells as well as on normal cells. The influence of P-gp on cancer drug delivery and the contribution of P-gp to activating drug resistance were also mentioned.
Transbronchial Cryobiopsy Compared to Forceps Biopsy for Diagnosis of Acute Cellular Rejection in Lung Transplants: Analysis of 63 Consecutive Procedures
Authors: Steinack Carolin , Gaspert Ariana , Gautschi Fiorenza , Hage René , Vrugt Bart , Soltermann Alex , Schuurmans Macé Matthew , Franzen Daniel
Published: June 2022

Background: Acute cellular rejection (ACR) is a complication after lung transplantation (LTx). The diagnosis of ACR is based on histologic findings using transbronchial forceps biopsy (FB). However, its diagnostic accuracy is limited because of the small biopsy size and crush artifacts. Transbronchial cryobiopsy (CB) provides a larger tissue size compared with FB. Methods: FB and CB were obtained consecutively during the same bronchoscopy (February 2020–April 2021). All biopsies were scored according to the ISHLT criteria by three pathologists. Interobserver agreement was scored by the kappa index. We assessed the severity of bleeding and the presence of pneumothorax. Results: In total, 35 lung transplant recipients were included, and 126 CBs and 315 FBs were performed in 63 consecutive bronchoscopies. ACR (A1–A3, minimal–moderate) was detected in 18 cases (28.6%) by CB, whereas ACR was detected in 3 cases (4.8%) by FB. Moderate and severe bleeding complicated FB and CB procedures in 23 cases (36.5%) and 1 case (1.6%), respectively. Pneumothorax occurred in 6.3% of patients. The interobserver agreement was comparable for both CB and FB. Conclusions: CB provided an improved diagnostic yield for ACR diagnosis, leading to reclassification and changes in treatment strategies in 28.6% of cases. Prospective studies should better define the role of CB after LTx.
In Vitro Characterization of the Human Skeletal Stem Cell-like Properties of Primary Bone-Derived Mesenchymal Stem/Stromal Cells in Patients with Late and Early Hip Osteoarthritis
Authors: Jasenc Lara , Stražar Klemen , Mihelič Anže , Mihalič Rene , Trebše Rihard , Haring Gregor , Jeras Matjaž , Zupan Janja
Published: June 2022

Human skeletal stem cells (hSSCs) were recently identified as podoplanin (PDPN)/CD73/CD164-positive and CD146-negative cells that decline with age, and play a role in the pathogenesis of osteoarthritis (OA). The aim of this study was to identify the hSSC-like properties of bone-derived mesenchymal stem/stromal cells (MSCs) of patients with late and early OA. Methods: First, we performed gene expression profiling for the hSSC markers in 32 patients with late and early OA, and donors without OA. Having identified the low expression of hSSC markers in late OA patients, we further performed trilineage differentiation and immunophenotyping for hSSC makers in the selected subsets from each donor group. Results: Our results show no differences in osteogenesis, chondrogenesis, and adipogenesis between the MSCs from the three groups. However, the immunophenotyping shows lower CD164 in MSCs from early OA patients in comparison with late and no OA subjects (p = 0.002 and p = 0.017). Conclusions: Our study shows that the in vitro hSSC-like properties of bone-derived MSCs are similar in patients with early and late OA, and in donors without OA. However, the lower percentage of CD164-positive MSCs in early OA patients indicates the potential of CD164 as a marker of the onset of OA.
Self-Reported Long COVID in the General Population: Sociodemographic and Health Correlates in a Cross-National Sample
Authors: Bonsaksen Tore , Leung Janni , Price Daicia , Ruffolo Mary , Lamph Gary , Kabelenga Isaac , Thygesen Hilde , Geirdal Amy Østertun
Published: June 2022

We aimed to gain knowledge of possible sociodemographic predictors of long COVID and whether long COVID was associated with health outcomes almost two years after the pandemic outbreak. There were 1649 adults who participated in the study by completing a cross-sectional online survey disseminated openly in Norway, the UK, the USA, and Australia between November 2021 and January 2022. Participants were defined as having long COVID based on self-reports that they had been infected by COVID-19 and were experiencing long-lasting COVID symptoms. Logistic regression analyses were used to examine possible sociodemographic predictors, and multivariate analysis of variance was used to examine whether long COVID status was associated with health outcomes. None of the sociodemographic variables was significantly associated with reporting long COVID. Having long COVID was associated with higher levels of psychological distress, fatigue, and perceived stress. The effect of long COVID on health outcomes was greater among men than among women. In conclusion, long COVID appeared across sociodemographic groups. People with long COVID reported worsened health outcomes compared to those who had had COVID-19 but without long-term symptoms. Men experiencing long COVID appear to be particularly vulnerable to experiencing poorer health outcomes; health services may pay extra attention to potentially unnoticed needs for support among men experiencing long COVID.
Evolution of Shear Surface Morphology of Jointed Rock Masses Based on Gaussian Filtering Method under Freeze-Thaw Cycles
Authors: Lei Daxing , Chen Yifan , Lin Hang , Zhang Chunshun , Lu Zhigang , Wang Guangli , Zhang Yaoping
Published: June 2022

This study aims to quantify the shear surface morphology of jointed rock and its evolution under shearing, cyclic freezing, and thawing using the Gaussian filtering method. Gaussian filtering method enables the construction of the (large-scale) waviness surface and the (small-scale) unevenness surface of a digitized surface (created by laser scanning). Both waviness and unevenness surfaces are then quantified by roughness coefficient ratio (S) and degradation degrees of the waviness surface (Dw) and unevenness surface (Dr). These (microscopic) morphological parameters (S, Dw and Dr) are subsequently used to explain the development of the (macroscopic) shear strength of the jointed rocks on direct shear tests. The results indicate that compared with fresh jointed rocks, the freezing and thawing causes the potential shear surface asperities to be easier to damage and fail under shear load. Such damage is well represented by the significant decrease in Dw and Dr. On the other hand, with the increase of the freeze-thaw cycle (N), Dw increases while Dr reaches the maximum at an early stage of the cycle, where Dr > Dw. This difference reveals the underlying shear mechanism microscopically; that is, in the initial stage, the shear surface morphology is mainly dominated by the unevenness surface Dr, and then it is controlled by the waviness surface Dw during the freeze-thaw cycle.
An Investigation on the Total Thickness Variation Control and Optimization in the Wafer Backside Grinding Process
Authors: Liu Yuanhang , Tao Hongfei , Zhao Dewen , Lu Xinchun
Published: June 2022

The wafer backside grinding process has been a crucial technology to realize multi-layer stacking and chip performance improvement in the three dimension integrated circuits (3D IC) manufacturing. The total thickness variation (TTV) control is the bottleneck in the advanced process. However, the quantitative analysis theory model and adjustment strategy for TTV control are not currently available. This paper developed a comprehensive simulation model based on the optimized grinding tool configuration, and several typical TTV shapes were obtained. The relationship between the TTV feature components and the spindle posture was established. The linear superposition effect of TTV feature components and a new formation mechanism of TTV shape were revealed. It illustrated that the couple variation between the two TTV feature components could not be eliminated completely. To achieve the desired wafer thickness uniformity through a concise spindle posture adjustment operation, an effective strategy for TTV control was proposed. The experiments on TTV optimization were carried out, through which the developed model and TTV control strategy were verified to play a significant role in wafer thickness uniformity improvement. This work revealed a new insight into the fine control method to the TTV optimization, and provided a guidance for high-end grinding tool and advanced thinning process development.
Sr and Zr Co-Doped CaCu3Ti4O12 Ceramics with Improved Dielectric Properties
Authors: Yu Yunfei , Wang Qun , Li Yongqing , Rehman Mehtab Ur , Khan Waheed Qamar
Published: June 2022

The dielectric constant of CCTO materials can be as high as 104, which makes it suitable for use in electronic devices but the high dielectric loss limits its application. In this paper, a series of Sr and Zr co-doped CCTO ceramics having the formula Ca0.8Sr0.2Cu3Ti4−xZrxO12 (x = 0.1, 0.2, 0.3, 0.4) were obtained via a solid-state reaction technique. We force the effect of the Zr content on the phase composition, microstructure, cationic valence states, impedance, and dielectric properties of the as-prepared ceramics to reduce dielectric loss. The results demonstrate that Sr and Zr co-doping increases dielectric constant and reduces dielectric loss simultaneously, and the maximum dielectric constant (1.87 × 105, 1 Hz) and minimum dielectric loss (0.43, 102 Hz) are obtained when x = 0.3. Mixed Cu+/Cu2+ and Ti3+/Ti4+ valence states are observed to coexist in the co-doped material lattices, which promote dipole polarization, and thereby increase the dielectric constant of the ceramics. The dielectric properties of the materials are analyzed according to the internal barrier layer capacitance model, which elucidates the contributions of the grains and grain boundaries to dielectric performance. The maximum grain boundary resistance (3.7 × 105 Ω) is obtained for x = 0.3, which contributes toward the minimum dielectric loss (0.43) obtained for this ceramic at a frequency less than 1 kHz. The average grain sizes of the samples decrease with increasing Zr content, which is the primary factor increasing the grain boundary resistance of the co-doped ceramics.
Friction Force Adjustment by an Innovative Covering System Applied with Superelastic NiTi Brackets and Wires—An In-Vitro Study
Authors: Wichelhaus Andrea , Eichenberg Tena , Gruber Philip , Bamidis Elias Panos , Stocker Thomas
Published: June 2022

The aim of this study was the investigation of polymeric coverings to adjust frictional forces between V-shaped wires and brackets, both made of superelastic NiTi. Adjustment of frictional forces is relevant for certain stages during orthodontic therapy. Coverings able to generate frictional forces when assembled to such brackets are additively manufactured. Six different internal widths of coverings were examined in three different environments: dry condition at room temperature (RT) or body temperature (BT), or artificial saliva (AS) at RT. The different coverings significantly affected the frictional forces for all media (p < 0.001). A correlation between internal width of the covering and resulting frictional forces was found. BT and dry environment showed the lowest friction forces for all samples. The highest force was found for two covering types at RT in AS, while the remaining four covering types showed the highest values in dry environment (p < 0.001). Friction could, therefore, be adjusted by variation of bracket covering clipped onto brackets, which is useful for orthodontic therapy. Coverings delivering higher friction provide dental anchorage, while coverings with lower friction can be used for tooth movement or purely esthetic reasons. It was shown that the variation of covering width may be used for adjustment of frictional forces.
Investigation of Interlaminar Shear Properties of CFRP Composites at Elevated Temperatures Using the Lempel-Ziv Complexity of Acoustic Emission Signals
Authors: Barile Claudia , Casavola Caterina , Pappalettera Giovanni , Kannan Vimalathithan Paramsamy , Renna Gilda
Published: June 2022

Three-point bending tests on Short Beam Shear (SBS) specimens are performed to investigate the interlaminar shear properties of plain weave fabric CFRP composites. The tests are performed in a controlled environmental chamber at two different elevated temperatures. The interlaminar shear properties of the specimens remain largely unaffected by the testing temperature. However, the SEM micrographs show different damage progressions between the specimens tested at 100 °C and 120 °C. Fibre ruptures and longer delamination between the plies, as a result of a high temperature, are observed in the specimens tested at 120 °C, which are not observed in the specimens tested at 100 °C. In addition, the acoustic emission activities during the tests are investigated by using piezoelectric sensors. The information-theoretic parameter, the Lempel-Ziv (LZ) complexity, is calculated for the recorded acoustic signals. The LZ Complexities are used for identifying the occurrence of the first delamination failure in the specimens. Additionally, the two features of the acoustic signals, LZ complexity and Weighted Peak Frequency (W.P-Freq), are used for distinguishing the different damage sources in the CFRP specimens. The results are well-supported by the time-frequency analysis of the acoustic signals using a Continuous Wavelet Transform (CWT).
Nano-Modified Vibrocentrifuged Concrete with Granulated Blast Slag: The Relationship between Mechanical Properties and Micro-Structural Analysis
Authors: Beskopylny Alexey N. , Shcherban’ Evgenii M. , Stel’makh Sergey A. , Mailyan Levon R. , Meskhi Besarion , Evtushenko Alexandr , Varavka Valery , Beskopylny Nikita
Published: June 2022

Currently, in civil engineering, the relevant direction is to minimize the cost of the manufacture of the hollow structures of annular sections, as well as their construction and installation efficiency. To optimize the costs associated with building products and structures, it is proposed to apply the technology of vibrocentrifugation, to reconsider and comprehensively approach the raw materials for the manufacture of such products and structures. The purpose of this study is a theoretical substantiation and experimental verification with analytical numerical confirmation of the possibility of creating improved variotropic structures of vibrocentrifuged concrete nano-modified with ground granulated blast-furnace slag. The study used the methods of electron microscopy, laser granulometry, and X-ray diffraction. Slag activation was carried out in a planetary ball mill; samples were prepared on a special installation developed by the authors—a vibrocentrifuge. The optimal and effective prescription–technological factors were experimentally derived and confirmed at the microlevel using structural analysis. The mathematical dependencies among the composition, macrostructure, microstructure, and final properties of vibrocentrifuged concrete nano-modified by slag are determined. Empirical relationships were identified to express the variation of some mechanical parameters and identify the relationship between them and the composition of the mixture. The optimal dosage of slag was determined, which is 40%. Increases in strength indicators ranged from 16% to 27, density—3%.