bluuebunny/crossref_metadata_2025 huggingface dataset:
Characterisation of a novel [18F]FDG brain PET database and combination with a second database for optimising detection of focal abnormalities, using focal cortical dysplasia as an example
Authors: Jin Sameer Omer , Mérida Inés , Stavropoulos Ioannis , Elwes Robert D. C. , Lam Tanya , Guedj Eric , Girard Nadine , Costes Nicolas , Hammers Alexander
Published: November 2023

Background

Brain [18F]FDG PET is used clinically mainly in the presurgical evaluation for epilepsy surgery and in the differential diagnosis of neurodegenerative disorders. While scans are usually interpreted visually on an individual basis, comparison against normative cohorts allows statistical assessment of abnormalities and potentially higher sensitivity for detecting abnormalities. Little work has been done on out-of-sample databases (acquired differently to the patient data). Combination of different databases would potentially allow better power and discrimination. We fully characterised an unpublished healthy control brain [18F]FDG PET database (Marseille, n = 60, ages 21–78 years) and compared it to another publicly available database (MRXFDG, n = 37, ages 23–65 years). We measured and then harmonised spatial resolution and global values. A collection of patient scans (n = 34, 13–48 years) with histologically confirmed focal cortical dysplasias (FCDs) obtained on three generations of scanners was used to estimate abnormality detection rates using standard software (statistical parametric mapping, SPM12).

Results

Regional SUVs showed similar patterns, but global values and resolutions were different as expected. Detection rates for the FCDs were 50% for comparison with the Marseille database and 53% for MRXFDG. Simply combining both databases worsened the detection rate to 41%. After harmonisation of spatial resolution, using a full factorial design matrix to accommodate global differences, and leaving out controls older than 60 years, we achieved detection rates of up to 71% for both databases combined. Detection rates were similar across the three scanner types used for patients, and high for patients whose MRI had been normal (n = 10/11).

Conclusions

As expected, global and regional data characteristics are database specific. However, our work shows the value of increasing database size and suggests ways in which database differences can be overcome. This may inform analysis via traditional statistics or machine learning, and clinical implementation.
Stochastic stability of solutions for a fourth-order stochastic differential equation with constant delay
Authors: Mahmoud Ayman M. , Adewumi Adebayo O. , Ademola Adeleke T.
Published: November 2023

In this paper, we present sufficient conditions to ensure the stochastic asymptotic stability of the zero solution for a specific type of fourth-order stochastic differential equation (SDE) with constant delay. By reducing the fourth-order SDE to a system of first-order SDEs, we utilize a fourth-order quadratic function to derive an appropriate Lyapunov functional. This functional is then employed to establish standard criteria for the nonlinear functions present in the SDE. The stability result obtained in this study is novel and extends the existing findings on stability in fourth-order differential equations. Additionally, we provide an illustrative example to demonstrate the significance and accuracy of our main result.
Stability and control in a stochastic model of malaria population dynamics
Authors: Witbooi Peter J. , Maku Vyambwera Sibaliwe , van Schalkwyk Garth J. , Muller Grant E.
Published: November 2023

This article proves a stability theorem for the disease-free equilibrium of a stochastic differential equations model of malaria disease dynamics. The theorem is formulated in terms of an invariant which is similar to the basic reproduction number of a related deterministic model. Compared to the deterministic model, stability of the disease-free equilibrium holds more generally for the stochastic model. The optimal control theory is applied to the stochastic model, revealing some important new insights. Theoretical results are illustrated by way of simulations.
Comovement between commodity returns in Ghana: the role of exchange rates
Authors: Barson Zynobia , Owusu Junior Peterson , Adam Anokye Mohammed
Published: November 2023

This paper examines the relationship between commodity returns in Ghana and if any, the role of exchange rate on such relationship using wavelet analysis and monthly data from September, 2007 to March, 2021. We test for the robustness of the empirical findings using multiple wavelet analysis. We find that exchange rate plays an intrinsic role in the dynamic comovement of commodity returns with strong coherence at short and medium terms. The partial wavelet coherence analysis shows that exchange rate drives commodity interdependence. This study is of relevance to other developing export-dependent countries and the Ghanaian government in making strategic trade policies and to investors that are interested in these cross-sector commodities. Governments and investors that are privy to the intrinsic role of exchange rate on its dependent commodities can benefit from this study to diversify against exchange rate fluctuations and the implicit effect of inflation.
Gene therapy-based strategies for spinal muscular atrophy—an Asia-Pacific perspective
Authors: Farrar Michelle A. , Calotes-Castillo Loudella , De Silva Ranil , Barclay Peter , Attwood Lani , Cini Julie , Ferrie Monica , Kariyawasam Didu S.
Published: November 2023

Onasemnogene abeparvovec has been life-changing for children with spinal muscular atrophy (SMA), signifying the potential and progress occurring in gene- and cell-based therapies for rare genetic diseases. Hence, it is important that clinicians gain knowledge and understanding in gene therapy-based treatment strategies for SMA. In this review, we describe the development and translation of onasemnogene abeparvovec from clinical trials to healthcare practice and share knowledge on the facilitators and barriers to implementation. Rapid and accurate SMA diagnosis, awareness, and education to safely deliver gene therapy to eligible patients and access to expertise in multidisciplinary management for neuromuscular disorders are crucial for health system readiness. Early engagement and intersectoral collaboration are required to surmount complex logistical processes and develop policy, governance, and accountability. The collection and utilisation of real-world evidence are also an important part of clinical stewardship, informing ongoing improvements to care delivery and access. Additionally, a research-enabled clinical ecosystem can expand scientific knowledge and discovery to optimise future therapies and magnify health impacts. Important ethical, equity, economic, and sustainability issues are evident, for which we must connect globally.
Baseline extracellular vesicle miRNA-30c and autophagic CTCs predict chemoradiotherapy resistance and outcomes in patients with lung cancer
Authors: de Miguel-Perez Diego , Ortega Francisco Gabriel , Tejada Rosario Guerrero , Martínez-Única Antonio , Peterson Christine B. , Russo Alessandro , Gunasekaran Muthukumar , Cardona Andres F. , Amezcua Victor , Lorente Jose Antonio , Expósito Hernández Jose , Rolfo Christian , Serrano Maria Jose
Published: November 2023

Concurrent chemoradiotherapy (cCRT) is the mainstay of treatment for patients diagnosed with locally advanced non-small cell lung cancer (NSCLC). One significant challenge in the effectiveness of this therapy is the potential development of resistance mechanisms, where autophagy up-regulation has been proposed as a key contributing factor. However, there is a lack of reliable biomarkers to predict outcomes on these patients. Interestingly, for addressing this gap, extracellular vesicles (EVs) and circulating tumor cells (CTCs) have emerged as potential sources of such biomarkers. In this study, we investigated EV-associated miRNAs and presence of autophagic CTCs in prospectively collected serial samples from 38 patients with stage III NSCLC undergoing cCRT. Our findings revealed that non-responders exhibited low levels of baseline EV miR-375, miR-200c, and miR-30c. In particular, EV miR-30c showed high predictive value with an area under the curve of 87.2%. Low EV miR-30c and the presence of autophagic-activated CTCs emerged as independent predictive biomarkers for shorter relapse-free survival and overall survival. Furthermore, in experimental models simulating the effects of chemo- and radiotherapy, the administration of miR-30c, either through direct transfection or encapsulation into human EVs, led to the inhibition of autophagy in these cells. This is the first report demonstrating that EV miR-30c inhibits tumor autophagy and its quantification, together with autophagic-activated CTCs, could be used as biomarkers for the stratification and monitoring of patients with NSCLC undergoing cCRT, and they may hold promising potential for guiding subsequent consolidation treatment with immunotherapy or other novel therapies based on autophagy inhibitors.
Effect of lactic acid bacteria and wheat bran on the fermentation quality and bacterial community of Broussonetia papyrifera silage
Authors: Wang Ningwei , Wang Yan , Lin Yanli , Xu Gang , Ni Kuikui , Yang Fuyu
Published: November 2023

Background

Paper mulberry has been considered as a high-quality protein feedstuff to cope with the shortage of feed and the development of livestock. In addition, the features of high moisture and low water-soluble carbohydrate concentration in fresh paper mulberry make it difficult to ensile. Therefore, it is important to find an optimal way to improve the paper mulberry silage quality. In this study, we aimed to investigate the application of Lactobacillus plantarum (LP) and wheat bran (WB) on the fermentation characteristics, chemical composition and microbial community of paper mulberry silage.

Results

The objective of this study was to evaluate the effects of Lactobacillus plantarum and wheat bran alone or combination (LP + WB) addition on the fermentation quality and bacterial community of paper mulberry silage. After 60 days of ensiling, the employed three treatments had higher crude protein contents compared with control (P < 0.05). More importantly, WB and LP + WB treatments significantly reduced the pH value and NH3-N concentration, and increased lactic acid content (P < 0.05). Microbial analysis indicated that the bacterial community in WB and LP + WB treatments showed distinct difference with LP and control. Lactobacillus was the dominant genera in all treatments. However, at the species level, Lactobacillus farciminis became the most dominant bacteria in control and LP treatments while the dominant bacteria in WB and LP + WB were Lactobacillus brevis and Lactobacillus farciminis. In addition, Lactobacillus brevis was positively correlated to crude protein and lactic acid and negatively correlated to pH and NH3-N. Overall, this study revealed that ensiling paper mulberry with WB or combination LP could improve silage quality through altering microbial community, which provided a practical approach for enhancing paper mulberry silage quality.

Conclusion

Wheat bran and combinations of Lactobacillus plantarum and wheat bran additions could reduce pH, NH3-N and increase LA content. The application of WB and LP + WB shifted the dominant bacteria species to Lactobacillus brevis. In summary, the addition of wheat bran and combinations of lactic acid bacteria and wheat bran were effective ways to enhance paper mulberry silage fermentation.

Graphical Abstract
Epidemiology of maxillofacial injury among adults in sub-Saharan Africa: a scoping review
Authors: Adeleke Adekunle I. , Hlongwa Mbuzeleni , Makhunga Sizwe , Ginindza Themba G.
Published: November 2023

Background

Injuries remain one of the leading causes of death globally. These disproportionately affect young adults and are particularly prevalent in sub-Saharan Africa (SSA). Maxillofacial injuries (MI) pose significant challenges to public health systems. However, much remains unknown regarding the epidemiology and extent of the financial burden in resource-limited areas, such as SSA, further necessitating more research and support. This scoping review aims to investigate the mechanism, distribution, and financial impact of MI in adults aged ≥ 18 years in SSA.

Main body

The scoping review was guided by the methodological frameworks of Arksey and O’Malley and Levac. An electronic literature search for English-published articles on maxillofacial injuries in adults ≥ 18 years was conducted in Scopus, Medline, PubMed, Science Direct, CINAHL, Health Source: Nursing/Academic Edition, and grey literature. The PRISMA chart was used to document database searches and screening outcomes while reporting was guided by PRISMA-ScR. The data extraction process revolved around the predefined study outcomes, which encompassed the study characteristics and epidemiological parameters. The review used a narrative approach to report findings and evaluate publication quality using the STROBE checklist.

The database search yielded 8246 studies, of which 30 met the inclusion criteria. A total of 7317 participants were included, 79.3% of whom were males. The peak age range for incidence was between 18 and 40 years. Road traffic collision (RTC) was the leading cause of MI, 59% of which resulted from motorcycle collisions. Assault/interpersonal violence ranked as the second leading cause of MI. The mandible was MI’s most frequently affected hard tissue, followed by the midface. Factors such as alcohol/illicit drug use, poor knowledge of traffic regulations, and non-observance of these regulations were associated with MI. In our study, the cost range for mandibular fractures was $200-$468.6, borne by victims and their families.

Conclusions

Maxillofacial injuries are predominantly caused by road traffic collisions and assaults in SSA. The findings can provide valuable insights into policy decisions and prevention strategies aimed at reducing injury burden. Further research is warranted to explore the psychological impact of MI, including PTSD, for tailored support and intervention.

Scoping Review RegistrationThe protocol has been registered on the Open Science Framework.RegistrationDOI:https://doi.org/10.17605/OSF.IO/BWVDK.
Protein content and amino acid composition in the diet of Danish vegans: a cross-sectional study
Authors: Aaslyng Margit D. , Dam Astrid Bøgebjerg , Petersen Iben Lykke , Christoffersen Tenna
Published: November 2023

Background

A growing proportion of the population are replacing their dietary animal protein with plant protein. A particular example of this trend is the vegan diet, which excludes all food items of animal origin. However, the DIAAS score for individual plant proteins is generally lower than that of animal proteins due to an unbalanced amino acid composition and lower bioavailability. Care must therefore be taken to meet the nutritional recommendations in the daily food intake.

Methods

A three-day dietary food record was carried out by 40 Danish vegans in a cross-sectional study. The data were analysed, with particular emphasis on protein requirements and the essential amino acid composition of the diet.

Results

The protein recommendations were met on all three days by 60% of the participants. In contrast, 18% did not meet the protein recommendations on any of the three days and 7% met the recommendations on only one of the days. Lysine was the most limiting amino acid (only 50% met the recommendations every day) followed by the sulphur-containing amino acids (recommendations met by 67.5%), leucine and valine (recommendations met by 70%). Combining both the amount of protein and the intake of the essential amino acids showed that less than half of the participants met the recommendations on all three days (47.5%) and 35% did not meet the recommendations on any days or on one day only.

Conclusion

In conclusion, our study showed that many of the participants in the present study failed to meet the daily protein intake requirements, both on single days and on all three days. Furthermore, the food intake was found to have an inadequate amino acid composition and was particularly limited by the essential amino acids lysine, the sulphur-containing amino acids, and leucine and valine. This could be ascribed to the fact that only a limited number of protein sources were consumed during a day.
The effects of using L1 Chinese or L2 English in planning on speaking performance among high- and low-proficient EFL learners
Authors: Liu Yingsheng , Yeung Pui-sze
Published: November 2023

Speaking constitutes one of the main goals of learning a second language (L2). Despite the increasing attention on the role of planning and language transfer in L2 learning, the combined effect of using different languages and pre-task planning on language production remains unclear. This study investigated whether the use of different languages in planning affects speaking performance and whether the effect differs by language proficiency. A total of 84 students in Chinese universities learning English as a foreign language participated in several speaking tasks after planning using their first language (L1) Chinese or L2 English. Findings showed that using L1 in planning results in significantly higher syntactic complexity, accuracy, and fluency in speaking performance than using L2 in planning, while the difference in lexical diversity were not statistically significant. Further analysis shows that for speech accuracy, the facilitative effect of L1 was stronger among low-proficient than high-proficient learners. Findings from this study support the use of L2 learners’ entire linguistic repertoire in speaking activities and provides implications on speech production theories as well as translanguaging pedagogies.
Promising improvement in infected Wound Healing in Type two Diabetic rats by Combined effects of conditioned medium of human adipose-derived stem cells plus Photobiomodulation
Authors: Sohrabi Kaysan , Ahmadi Houssein , Amini Abdollah , Ahrabi Behnaz , Mostafavinia Atarodalsadat , Omidi Hamidreza , Mirzaei Mansooreh , Fadaei Fathabady Fatemeh , Fridoni Mohammadjavad , Rahmannia Maryam , Chien Sufan , Bayat Mohammad
Published: November 2023

Background

We aimed to examine the accompanying and solo impacts of conditioned medium of human adipose-derived stem cells (h-ASC-COM) and photobiomodulation (PBM) on the maturation stage of an ischemic infected delayed-healing wound model (IIDHWM) of rats with type 2 diabetes (TIIDM).

Results

Outcomes of the wound closure ratio (WCR) results, tensiometrical microbiological, and stereological assessment followed almost identical patterns. While the outcomes of h-ASC-COM + PBM, PBM only, and h-ASC-COM only regimes were significantly better for all evaluated methods than those of group 1(all, p < 0.001), PBM alone and h-ASC-COM + PBM therapy achieved superior results than h-ASC-COM only (ranged from p = 0.05 to p < 0.001). In terms of tensiometrical and stereological examinations, the results of h-ASC-COM + PBM experienced better results than the PBM only (all, p < 0.001).

Conclusions

h-ASC-COM + PBM, PBM, and h-ASC-COM cures expressively accelerated the maturation stage in the wound healing process of IIDHWM with MRSA in TIIDM rats by diminishing the inflammatory reaction, and the microbial flora of MRSA; and increasing wound strength, WCR, number of fibroblasts, and new blood vessels. While the h-ASC-COM + PBM and PBM were more suitable than the effect of h-ASC-COM, the results of h-ASC-COM + PBM were superior to PBM only.
Compositional changes in fecal microbiota in a new Parkinson's disease model: C57BL/6-Tg(NSE-haSyn) mice
Authors: Kim Ji Eun , Kwon Ki Chun , Jin You Jeong , Seol Ayun , Song Hee Jin , Roh Yu Jeong , Kim Tae Ryeol , Park Eun Seo , Park Gi Ho , Park Ji Won , Jung Young Suk , Cho Joon Yong , Hwang Dae Youn
Published: November 2023

Background

The gut–brain axis (GBA) in Parkinson's disease (PD) has only been investigated in limited mice models despite dysbiosis of the gut microbiota being considered one of the major treatment targets for neurodegenerative disease. Therefore, this study examined the compositional changes of fecal microbiota in novel transgenic (Tg) mice overexpressing human α-synuclein (hαSyn) proteins under the neuron-specific enolase (NSE) to analyze the potential as GBA model.

Results

The expression level of the αSyn proteins was significantly higher in the substantia nigra and striatum of NSE-hαSyn Tg mice than the Non-Tg mice, while those of tyrosine hydroxylase (TH) were decreased in the same group. In addition, a decrease of 72.7% in the fall times and a 3.8-fold increase in the fall number was detected in NSE-hαSyn Tg mice. The villus thickness and crypt length on the histological structure of the gastrointestinal (GI) tract decreased in NSE-hαSyn Tg mice. Furthermore, the NSE-hαSyn Tg mice exhibited a significant increase in 11 genera, including Scatolibacter, Clostridium, Feifania, Lachnoclostridium, and Acetatifactor population, and a decrease in only two genera in Ligilactobacillus and Sangeribacter population during enhancement of microbiota richness and diversity.

Conclusions

The motor coordination and balance dysfunction of NSE-hαSyn Tg mice may be associated with compositional changes in gut microbiota. In addition, these mice have potential as a GBA model.
Novel scoring system using contrast-enhanced mammography to differentiate benign and malignant architectural distortion
Authors: Renganathan Rupa , Subramaniam Prema , Mandal Adrija , Suganya P. , Shanmugam Jeevithan , Cherian Mathew
Published: November 2023

Background

Incidence of malignancy in architectural distortion (AD) is variable, and as a standard of care, all the architectural distortions are biopsied. It is important to identify benign and malignant characteristics of ADs on imaging to predict the probability of malignancies as well as to establish radiological–pathological concordance. The aim of our study was to analyse the utility of contrast-enhanced mammography (CEM) in primary AD, to describe and evaluate the accuracy of CEM parameters and derive a novel scoring system to differentiate benign and malignant AD.

Results

Forty-six patients with 49 ADs were evaluated with a median age, 51 years (age range—34–72 years) and all were women. Of the 49 ADs, 65.3% (32/49) were benign, and 34.69% (17/49) were malignant. The CEM parameters which predicted malignancy were moderate or marked density, size > 0.95 cm, CT ratio > 1.31, mass morphology and washout kinetics. The absence of enhancement and enhancing AD with AD score of 0 had a 100% NPV for malignancy. Enhancing architectural distortion with a score of 3 or more had 100% PPV for malignancy. A score of 1 or 2 was indeterminate, and an individualised decision was recommended.

Conclusions

In primary AD, several CEM features have significantly predicted malignancy when the score is 3 and above. A biopsy may be avoided in non-enhancing AD and enhancing AD with a score of 0 due to high NPV.
Bayesian reverse time migration with quantified uncertainty
Authors: Wang Shuang , Gong Xiangbo , Huang Xingguo , Rao Jing , Jensen Kristian , Han Li , Wang Naijian , Zhang Xuliang
Published: November 2023

Reverse time migration (RTM) has been proven capable of producing high-quality images of subsurface structures. However, limited subsurface illumination combined with inaccurate forward modeling and migration velocities all lead to uncertainty in the seismic images. We quantify the migration uncertainty of RTM using an iterative inversion method based on a Bayesian inference framework. The posterior covariance matrix, computed at the maximum a posteriori (MAP) model, provides the foundation for estimating uncertainty. In the Bayesian inference framework, we combine an explicit sensitivity matrix based on a Green’s function representation with an iterative extended Kalman filter method. This enables us to determine the MAP solution of RTM and an estimate of its uncertainty. Numerical examples using synthetic data demonstrate how well the method can measure RTM uncertainty and produce reliable imaging results.
The association of anxiety disorders and depression with facial scarring: population-based, data linkage, matched cohort analysis of 358 158 patients
Authors: Gibson John A. G. , Dobbs Thomas D. , Griffiths Rowena , Song Jiao , Akbari Ashley , Bodger Owen , Hutchings Hayley A. , Lyons Ronan A. , John Ann , Whitaker Iain S.
Published: November 2023

Background

Estimates suggest that 1 in 100 people in the UK live with facial scarring. Despite this incidence, psychological support is limited.

Aims

The aim of this study was to strengthen the case for improving such support by determining the incidence and risk factors for anxiety and depression disorders in patients with facial scarring.

Method

A matched cohort study was performed. Patients were identified via secondary care data sources, using clinical codes for conditions resulting in facial scarring. A diagnosis of anxiety or depression was determined by linkage with the patient's primary care general practice data. Incidence was calculated per 1000 person-years at risk (PYAR). Logistic regression was used to determine risk factors.

Results

Between 2009 and 2018, 179 079 patients met the study criteria and were identified as having a facial scar, and matched to 179 079 controls. The incidence of anxiety in the facial scarring group was 10.05 per 1000 PYAR compared with 7.48 per 1000 PYAR for controls. The incidence of depression in the facial scarring group was 16.28 per 1000 PYAR compared with 9.56 per 1000 PYAR for controls. Age at the time of scarring, previous history of anxiety or depression, female gender, socioeconomic status and classification of scarring increased the risk of both anxiety disorders and depression.

Conclusions

There is a high burden of anxiety disorders and depression in this patient group. Risk of these mental health disorders is very much determined by factors apparent at the time of injury, supporting the need for psychological support.
Soft Tissue Sarcomas in Adolescents and Young Adults
Authors: Weiss Aaron R. , Harrison Douglas J.
Published: November 2023

Soft tissue sarcomas (STS) represent a heterogeneous group of extraskeletal mesenchymal tumors that affect individuals throughout the entire age continuum. Despite this pervasive influence, key differences exist in the presentation of these sarcomas across varying age groups that have prevented a more uniform approach to management. Notably, rhabdomyosarcoma (RMS) is more common in children, while most nonrhabdomyosarcoma soft tissue sarcoma (NRSTS) subtypes are more prevalent in adults. Older patients with NRSTS appear to have more molecularly complex biology and often present with more advanced disease compared with children. Poorer outcome disparities are observed in older patients with RMS despite receiving similar treatment as younger patients. In this review, we highlight differences in epidemiology, biology, and management paradigms for pediatric and adult patients with STS and explore opportunities for a unified approach to enhance the care and outcomes within the AYA population.
Current Practices, Perceived Barriers, and Promising Implementation Strategies for Improving Quality of Smoking Cessation Support in Accredited Cancer Programs of the American College of Surgeons
Authors: Ostroff Jamie S. , Reilly Eileen M. , Burris Jessica L. , Warren Graham W. , Shelton Rachel C. , Mullett Timothy W. ,   the Just ASK Quality Improvement Task Force, Adsit Rob , Allison Lisa , Boffa Daniel , Burris Jessica , Carter Asa , Darville Audrey , Fiore Michael , Hahn Ellen , Harris James , Kirstein Laurie , McCarthy Danielle , Mullett Timothy , Nelson Heidi , Ostroff Jamie , Reilly Eileen , Reuter Erin , Shafir Sarah , Shelton Rachel , Tong Elisa , Warren Graham
Published: November 2023

PURPOSE

Persistent smoking is associated with poor outcomes in cancer care. It is strongly recommended that oncology care providers provide cessation support; however, there is limited information about smoking cessation assessment and treatment patterns in routine oncology practice.

METHODS

Leaders of the American College of Surgeons Commission on Cancer (CoC) and National Accreditation Program for Breast Centers (National Accredited Program for Breast Cancer) elected to participate in a national quality improvement initiative (Just ASK) focused on smoking assessment/treatment in cancer care. Online baseline survey responses were received from 762 accredited programs.

RESULTS

Most programs reported regularly asking about smoking (89.9%), documenting smoking history and current use (85.8%), and advising patients to quit (71.2%). However, less than half of programs reported documenting a smoking cessation treatment plan (41.7%). Even fewer programs reported regularly assisting patients with quitting (41.3%), providing self-help information (27.2%), providing individual counseling (18.2%), and referring patients to an affiliated tobacco treatment program (26.1%) or external Quitline (28.5%). Very few programs reported regularly prescribing medications (17.6%). Principal barriers to tobacco treatment delivery were lack of staff training (68.8%), lack of designated specialists (61.9%), perceived patient resistance (58.3%), lack of available resources (53.3%), competing clinical priorities (50.9%), inadequate program funding (40.6%), insufficient staff time (42.4%), and inadequate reimbursement (31.0%).

CONCLUSION

Although programs reported a high rate of smoking assessment, critical gaps in advising and assisting patients with cessation were found. Improving equitable delivery of smoking assessment/treatment in cancer care will require addressing key organizational and provider barriers for implementation of best practices.
Dorsal Root Ganglion Stimulation to Treat Chronic Shoulder Pain: A Case Report
Authors: Chapman Kenneth B. , Tupper Connor , Yousef Tariq , van Helmond Noud
Published: November 2023

A 67-year-old man presented with severe 9 of 10 intractable pain of the left shoulder joint after arthroplasty and revision surgeries, with associated weakness, atrophy, and limited range of motion in all directions. Dorsal root ganglion stimulation (DRG-S) at the left C4, C5, and C6 levels was used after failed conservative and interventional measures, resulting in significant improvement in pain, function, and quality of life measures through 6 months postimplantation. Larger studies should examine if DRG-S is effective in treating chronic arthritic joint pain as well as chronic postsurgical pain of the shoulder that is not predominantly neuropathic.
Tranexamic Acid in Cardiac Surgery: A Case Report of an Infrequent Adverse Reaction to a Common Medication.
Authors: Sanchez Salcedo Lisa , Manuel Baloira Federico , Adrover Alejo , Bianco Juan C. , Garcia Guzzo Maria Eugenia
Published: November 2023

Life-threatening anaphylaxis to tranexamic acid (TXA) is rare but critical in cardiac surgery. A 76-year-old patient undergoing elective ascending aorta replacement developed severe anaphylactic shock shortly after anesthesia induction. Subsequent skin prick tests confirmed a positive TXA reaction. While TXA and lysine derivatives were avoided in the second surgery, the patient experienced hyperfibrinolysis. Guided by rotational thromboelastometry, hemostatic therapy led to a successful outcome with minimal postoperative bleeding. This report emphasizes the importance of drug risk awareness and strategies to mitigate excessive bleeding in cardiac surgery.
Case Report: Spontaneous pneumothorax revealing multiple myeloma: a case report
Authors: Brahem Mouna , BenTekaya Ramy , Touil Imen , Braham Yosra , Jomaa Olfa , Bousoffara Leila , knani Jalel , Boudawara Nedia , Hachfi Haifa , Younes Mohamed
Published: November 2023

Various causes like trauma, infection, pulmonary disease or neoplasm can lead to spontaneous pneumothorax. We report a rare case of a spontaneous pneumothorax as first manifestation of multiple myeloma. A 58-year-old patient presented suffering from dyspnea and right-sided chest pain, with no history of trauma. On examination, the patient had bilateral rib tenderness. The respiratory rate was 30 breaths/min and oxygen saturation was 88%. The chest physical exam revealed unequal breath sounds, an hyperresonance with percussion and decreased wall movement on the right side. The analysis of arterial blood gas revealed hypoxemia (arterial oxygen tension: 7.59 kPa) and hypercapnia (arterial carbon dioxide tension: 5.99 kPa). Laboratory data showed a raised C reactive protein level (133.8 mg/L), hyper-calcemia (serum calcium: 12.18 mg/dL) and a decreased plasma albumin level (31.9 g/L). The hemoglobin rate was 13.4 g/dl and the serum creatinine.was normal at 34 µmol/l. Chest radiography and thoracic computed tomography revealed multiple ribs and sternum fractures leading to a partial pneumothorax on the right side. Subsequent workup for multiple myeloma showed elevated levels of immunoglobulin. Results of initial laboratory tests revealed an IgG gamma paraprotein, a urine protein electrophoresis of 1450 mg/24 hours and a β-2 microglobulin rate of 3.35. The diagnosis of multiple myeloma was confirmed with a bone marrow infiltration of 20% of atypical plasmatic cells. Cytogenetic investigations with FISH method did not show any chromosomal abnormalities, especially the t (4,14) translocation. The patient was diagnosed with multiple myeloma stage IIIA according to Durie–Salmon classification. Appropriate treatment with oxygen therapy and systemic analgesic was started, associated with a cure of zoledronic acid in order to decrease the calcium level. The evolution was characterized by the complete resolution of the pneumothorax in 7 days, the hypoxemia due to pneumothorax was improved and the calcium level was ormalized. The autologous stem cell transplant was the treatment of choice for this patient.
Preliminary study of physicochemical, thermal, rheological, and interfacial properties of quinoa oil
Authors: Castaño-Ángel Cristhian Camilo , Tarapues-Cuasapud Jesús Alexander , Bravo-Gómez Jesús Eduardo , Solanilla-Duque Jose Fernando , Roa-Acosta Diego Fernando
Published: November 2023

Background: The growing popularity of nutrient-rich foods, among which is quinoa, is due to the increasing demand for healthier choices. Oils and hydrolyzed proteins from these foods may help prevent various health issues. The objective of this work was to perform extraction from the endosperm of the grain from high-protein quinoa flour by physical means via a differential abrasive milling process and extracting the oil using an automatic auger extractor at 160°C, as well as characterizing extracted oil.

Methods: Quinoa oil extraction and physicochemical characterization were carried out. Chemical and physical quality indexes of quinoa oil were established, and both characterizations were conducted based on international and Columbian standards. Thermal properties were evaluated by differential scanning calorimetry, and rheological and interfacial properties of the oil were evaluated using hybrid rheometers and Drop Tensiometers, respectively, to determine its potential for obtaining functional foods.

Results: The result was 10.5 g of oil/ 100 g of endosperm, with a moisture content of 0.12%, insoluble impurities of 0.017%, peroxide index of 18.5 meq O2/kg of oil, saponification index of 189.6 mg potassium hydroxide/g of oil, refractive index of 1.401, and a density of 0.9179 g/cm3 at 20°C. Regarding contaminating metals, it presented 7 mg of iron/kg of oil, a value higher than previously established limits of 5 mg of iron/kg of oil. The oil contained 24.9% oleic acid, 55.3% linoleic acid, and 4% linolenic acid, demonstrating antioxidant capacity. Quinoa oil showed thermal properties similar to other commercial oils.

Conclusions: The interfacial and rheological properties were suitable for the stabilization of emulsions, gels, and foams, which are important in various industrial applications and could facilitate the development of new products. The extracted quinoa oil presented similar characteristics to other commercial oils, which could make it a potential product for commercialization and application in different industries.
Comparison between Tazarotene 0.05% gel and Adapelene 0.1% gel in acne patients
Authors: Jaiswal Sharwari , Jawade Sugat
Published: November 2023

Background: Acne is an extremely common skin condition, which has a major social and psychological impact on young patients. Retinoids have been a mainstay of anti-acne therapy. Older generation agents are slowly replaced by newer generation ones like tazarotene and adapalene as they exhibit lower toxicologic risk and less side effects and they effectively reduce the comedones and inflammatory lesions. This study throws light on effectiveness of topical Adapalene gel- 0.1% and Tazarotene gel-0.05% in order to find out a suitable option with lesser side effects for acne patients. Methods: After clearance from the institutional ethics committee, acne patients aged >12-35 years at the outpatient area of the Dermatology department, AVBRH, Jawaharlal Nehru Medical College, Sawangi, Wardha, were enrolled in the study. Patients will be randomly assigned in two groups wherein group A will be prescribed Tazarotene-0.05% gel and group B prescribed Adapalene-0.1% gel along with Tab Azithromycin-500mg thrice weekly for 12 weeks for both groups. Patients will be clinically assessed on every 4th, 8th and 12th week. Global acne score system will be applied at enrolment and at each subsequent follow-up for evaluation.
Communicative Abbreviation of Computer Discourse
Authors: Abramov Vladimir , Husnullina Yulia
Published: November 2023

The monography is devoted to abbreviation of computer discourse terms and abbreviated elements of computer communication. The course and results of analysis are interpreted in a logical sequence along with the described principles of systematization, its goals and objectives. The compression of multicomponent nominations denoting objects of the computer industry and the achievement of informativeness in the course of computer communication are presented as mechanisms contributing to the development of abbreviation models that require timely lexicographic registration and adequate lexical description. The study was conducted on the material of English-language texts and text-based computer communications, thereby providing a holistic perception of abbreviation models and reflecting the specifics of their use in the speech of professional PC users. The publication is intended for researchers, teachers, postgraduates of linguistic and linguocultural specialties and for those who are interested in the problems of abbreviation in modern developed languages.
A Heuristic for Combining Correlated Experts When There Are Few Data
Authors: Soule David , Grushka-Cockayne Yael , Merrick Jason
Published: November 2023

It is intuitive and theoretically sound to combine experts’ forecasts based on their proven skills, while accounting for correlation among their forecast submissions. Simpler combination methods, however, which assume independence of forecasts or equal skill, have been found to be empirically robust, in particular, in settings in which there are few historical data available for assessing experts’ skill. One explanation for the robust performance by simple methods is that empirical estimation of skill and of correlations introduces error, leading to worse aggregated forecasts than simpler alternatives. We offer a heuristic that accounts for skill and reduces estimation error by utilizing a common correlation factor. Our theoretical results present an optimal form for this common correlation, and we offer Bayesian estimators that can be used in practice. The common correlation heuristic is shown to outperform alternative combination methods on macroeconomic and experimental forecasting where there are limited historical data.

This paper was accepted by Ilia Tsetlin, behavioral economics and decision analysis.

Supplemental Material: The data file is available at https://doi.org/10.1287/mnsc.2021.02009 .
Exposure to the Views of Opposing Others with Latent Cognitive Differences Results in Social Influence—But Only When Those Differences Remain Obscured
Authors: Guilbeault Douglas , van Loon Austin , Lix Katharina , Goldberg Amir , Srivastava Sameer B.
Published: November 2023

Cognitive differences can catalyze social learning through the process of one-to-one social influence. Yet the learning benefits of exposure to the ideas of cognitively dissimilar others often fail to materialize. Why do cognitive differences produce learning from interpersonal influence in some contexts but not in others? To answer this question, we distinguish between cognition that is expressed—one’s public stance on an issue and the way in which supporting arguments are framed—and cognition that is latent—the semantic associations that underpin these expressions. We theorize that, when latent cognition is obscured, one is more likely to be influenced to change one’s mind on an issue when exposed to the opposing ideas of cognitively dissimilar, rather than similar, others. When latent cognition is instead observable, a subtle similarity-attraction response tends to counteract the potency of cognitive differences—even when social identity cues and other categorical distinctions are inaccessible. To evaluate these ideas, we introduce a novel experimental paradigm in which participants (a) respond to a polarizing scenario; (b) view an opposing argument by another whose latent cognition is either similar to or different from their own and is either observable or obscured; and (c) have an opportunity to respond again to the scenario. A preregistered study (n = 1,000) finds support for our theory. A supplemental study (n = 200) suggests that the social influence of latent cognitive differences operates through the mechanism of argument novelty. We discuss implications of these findings for research on social influence, collective intelligence, and cognitive diversity in groups.

This paper was accepted by David Simchi-Levi, organizations.

Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2022.00895 .
Network Referrals and Self-Presentation in the High-Tech Labor Market
Authors: Campero Santiago , Kacperczyk Aleksandra (Olenka)
Published: November 2023

The practice of recruiting job candidates sourced through social contacts (i.e., referrals) is pervasive in the labor market. One reason employers prefer to recruit through referrals is that these candidates often present resumes that are perceived to be a better fit for the role. Whereas existing research attributes this pattern to how individuals who make referrals (i.e., referrers) select individuals to refer, we propose a new mechanism: differences in self-presentation. We argue that referral ties increase the candidates’ propensity to engage in self-presentation work, motivating and assisting candidates in presenting their backgrounds to convey fit. We examine this claim by utilizing unique data from an applicant-tracking system containing job applications for positions at U.S.-based high-tech firms between 2008 and 2012. A candidate fixed-effects specification reveals that when a candidate applies to a firm via a referral, he or she tends to showcase a rendition of his or her career history that better matches the target job than when the candidate pursues positions without such ties. Several mechanism checks, combined with supplementary survey evidence, further indicate that the presence of referral ties to the target firm is associated with greater motivation to engage in self-presentation work as well as the provision of different forms of assistance in that work.

Supplemental Material: The e-companion is available at https://doi.org/10.1287/orsc.2022.16674 .
Adult-onset hypophosphatemic osteomalacia as a cause of widespread musculoskeletal pain: A retrospective case series of single center experience
Authors: Kim Sungwon , Kim Sun Woong , Lee Byung Chan , Kim Du Hwan , Sung Duk Hyun
Published: November 2023

BACKGROUND

Osteomalacia (OM) is frequently confused with various musculoskeletal or other rheumatic diseases, especially in patients with adult-onset widespread musculoskeletal pain because of its low prevalence and non-specific manifestations.

AIM

To facilitate the early diagnosis and etiology-specific treatment of adult-onset hypophosphatemic OM.

METHODS

A retrospective review of medical records was performed to screen adult patients who visited a physiatry locomotive medicine clinic (spine and musculoskeletal pain clinic) primarily presenting with widespread musculoskeletal pain at a single tertiary hospital between January 2011 and December 2019. We enrolled patients with hypophosphatemia, high serum bone-specific alkaline phosphatase levels, and at least one imaging finding suggestive of OM.

RESULTS

Eight patients with adult-onset hypophosphatemic OM were included. The back was the most common site of pain. Proximal dominant symmetric muscle weakness was observed in more than half of the patients. Bone scintigraphy was the most useful imaging modality for diagnosing OM because radiotracer uptake in OM showed characteristic patterns. Six patients were diagnosed with adefovir (ADV)-induced Fanconi syndrome, and the other two patients were diagnosed with tumor-induced OM and light-chain nephropathy, respectively. After phosphorus and vitamin D supplementation and treatment for the underlying etiologies, improvements in pain, muscle strength, and gait were observed in all patients.

CONCLUSION

Mechanical pain characteristics, hypophosphatemia, and distinctive bone scintigraphy patterns are the initial diagnostic indicators of adult-onset hypophosphatemic OM. ADV-induced Fanconi syndrome is the most common etiology of hypophosphatemic OM in hepatitis B virus-endemic countries.
Interstitial pneumonia combined with nocardia cyriacigeorgica infection: A case report
Authors: Qi Dao-Da , Zhuang Yi , Chen Yang , Guo Jing-Jing , Zhang Ze , Gu Yan
Published: November 2023

BACKGROUND

Nocardia infection is a relatively uncommon disease, with no reports among patients with interstitial pneumonia. Due to its atypical clinical symptoms and chest computed tomography (CT) findings and the frequent yielding of negative results by conventional cultures, it poses challenges for timely diagnosis and treatment.

CASE SUMMARY

A 63-year-old female patient presented to our hospital in July 2022 with a 3-mo history of intermittent cough and poor appetite, accompanied by a 2-wk long duration of headaches. She had a previous medical history of interstitial pneumonia and was on oral prednisone and cyclosporine. Chest CT revealed the presence of newly developed round nodules. The diagnosis of Nocardia cyriacigeorgica infection was confirmed through metagenomic next-generation sequencing (mNGS) performed on bronchoalveolar lavage fluid. Targeted anti-infection therapy was initiated, resulting in symptom improvement and radiological resolution, further validating the mNGS results.

CONCLUSION

Nocardia cyriacigeorgica infection is a clinically rare condition that is primarily observed in immunocompromised patients. Its clinical and radiological manifestations lack specificity, but mNGS can aid in rapidly obtaining pathogenic information. Early initiation of targeted antimicrobial therapy based on mNGS results can improve patient prognosis.
Brane Theory
Authors: Ting Sher
Published: November 2023

Abstract: This poem reflects on our existence as metaphors for branes, multidimensional objects that hold within themselves infinite possibilities - yet within these, there is difficulty breaking through what has been dictated for them by the universe. Even amidst the notions of deductive reasoning and empirical thought, we are taught to be satisfied with what has been allotted. Nevertheless, life has a way of surpassing even the finitude of our biggest legends.