bluuebunny/crossref_metadata_2025 huggingface dataset:
Early Lactate-Guided Resuscitation of Elderly Septic Patients
Authors: Chen Hui , Xu Jiangqing , Wang Xia , Wang Yaxuan , Tong Fei
Published: June 2021

Background:

Early lactate-guided resuscitation was endorsed in the guidelines of the Surviving Sepsis Campaign as a key strategy to decrease the mortality of patients admitted to the ICU department with septic shock. However, its effectiveness in elderly Asian patients is uncertain.

Method:

We conducted a single-center trial to test the effectiveness of the early lactate-guided resuscitation of older Asian patients at the Second Hospital of Hebei Medical University. Eligible septic shock patients who consented to participation in the study were randomly assigned to receive early lactate-guided treatment or regular treatment as controls.

Result:

A total of 82 patients met the hyperlactatemia criteria and participated in the trial. Forty-two patients received early lactate-guided treatment (lactate group) and 40 received regular treatment (control group). The lactate group received more fluids at initial 6 hours (3.3 ± 1.4 vs 2.4 ± 1.7 L, P = 0.01), but similar proportions of patients in both groups required the use of vasopressors and vasodilators. Patients in the lactate group showed significantly reduced ICU needs compared to the control group, which were weaned from mechanical ventilation more quickly (median 7, IQR 4 to 14 vs median 9, IQR 4.3 to 17.8, P = 0.02) and transferred out of the ICU earlier (median 4.5, IQR 2.8 to 7.3 vs median 6, IQR 3.2 to 8, P = 0.01). However, the hospital mortality (35.7% vs 42.5%, P = 0.35) and ICU mortality (31.0% vs 37.5%, P = 0.38) for both groups were not reduced.

Conclusion:

For critically ill patients (elderly Asian patients) admitted to the ICU department with hyperlactatemia, early lactate-guided treatment reduced ICU needs but did not reduce mortality.
How Community and Individual Risk Factors Mutually Impact Youth’s Perceived Safety: A Syndemic Analysis Using Structural Equation Modeling
Authors: Yang Yingwei , Liller Karen D. , Coulter Martha , Salinas-Miranda Abraham , Tyson Dinorah Martinez , Chen Henian
Published: June 2021

The purpose of this study was to evaluate the mutual impact of community and individual factors on youth’s perceptions of community safety, using structural equation modeling (SEM) conceptualized by syndemic theory. This study used survey data collected from a county wide sample of middle and high school students (N=25,147) in West Central Florida in 2015. The outcome variable was youth’s perceptions of community safety. Predictors were latent individual and community factors constructed from 14 observed variables including gun accessibility, substance use, depressive symptoms, and multiple neighborhood disadvantage questions. Three structural equation models were conceptualized based on syndemic theory and analyzed in Mplus 8 using weighted least squares (WLS) estimation. Each model’s goodness of fit was assessed. Approximately seven percent of youth reported feeling unsafe in their community. After model modifications, the final model showed a good fit of the data and adhered to the theoretical assumption. In the final SEM model, an individual latent factor was implied by individual predictors measuring gun accessibility without adult’s permission (β=0.70), sadness and hopelessness (β=0.52), alcohol use (β=0.79), marijuana use (β=0.94), and illegal drug use (β=0.77). Meanwhile, a community latent factor was indicated by multiple community problems including public drinking (β=0.88), drug addiction (β=0.96), drug selling (β=0.97), lack of money (β=0.83), gang activities (β=0.90), litter and trash (β=0.79), graffiti (β=0.91), deserted houses (β=0.86), and shootings (β=0.93). A second-order syndemic factor that represented the individual and community factors showed a very strong negative association with youth’s safe perception (β=-0.98). This study indicates that individual risk factors and disadvantaged community conditions interacted with each other and mutually affected youth’s perceptions of community safety. To reduce these co-occurring effects and improve safe perceptions among youth, researchers and practitioners should develop and implement comprehensive strategies targeting both individual and community factors.
Determination of chemical structure, mechanical properties and combustion resistance of polyurethane doped with boric acid
Authors: Kaya Ali Ihsan
Published: June 2021

The low fire resistance property of pristine polyurethane (PU) restricts its areas of usage in domestic applications and especially in the furniture industry. Therefore, PU based materials should be non-flammable besides having favorable mechanical and chemical properties. In this study, boric acid (BA) was added to the polyurethane foam as fire retardant. The effect of amount of BA (5%, 10%, and 15% (w/w)) on fire retardancy was examined. The thermal properties and the surface morphology of the structures were investigated. The amount of BA affected surface morphology. It was observed that BA affects the density and compressive strength in three directions with the physical change it causes in the cell structure. In the X-ray diffraction analysis of the unmodified hard polyurethane and the hard polyurethanes containing BA at different amounts (5%, 10%, and 15% (w/w)), the peaks were observed to appear in three different groups. The thermal stability of the rigid PU treated with BA was investigated via thermogravimetric analysis and the limiting oxygen index (LOI) analysis. The electromagnetic interference shielding effectiveness (EMI SE) was measured via a system consisting of two anechoic boxes and receiving and transmitting antennas. Four different temperature zones were observed when examining the thermal behavior via differential scanning calorimetry. Single source flame test, UL94 test and cone calorimeter tests were performed to determine the ignition property of BA doped PU. It was determined that BA is a better fire retardant than other chemicals also for the low toxicity of the combustion products formed.
Nasalance Scores for Normal Speakers of American English Obtained by the Nasometer II Using the MacKay-Kummer SNAP-R Test
Authors: Alfwaress Firas , Kummer Ann W. , Weinrich Barbara
Published: June 2021

Objective:

To establish nasalance score norms for adolescent and young adult native speakers of American English and also determine age-group and gender differences using the Simplified Nasometric Assessment Procedures (SNAP) Test-R and Nasometer II.

Design:

Prospective study using a randomly selected sample of participants.

Setting:

Greater Cincinnati area and Miami University of Ohio.

Participants:

Participants had a history of normal speech and language development and no history of speech therapy. Participants in the adolescent group were recruited from schools in West Clermont and Hamilton County, whereas the young adults were recruited from Miami University of Ohio. The participants of both groups were residents of Cincinnati, Ohio or Oxford, Ohio and spoke midland American English dialect.

Outcome Measures:

Mean nasalance scores for the SNAP Test-R.

Results:

Normative nasalance scores were obtained for the Syllable Repetition/Prolonged Sounds, Picture-Cued, and Paragraph subtests. Results showed statistically significant nasalance score differences between adolescents and young adults in the Syllable Repetition, Picture-Cued, and Paragraph subtests, and between males and females in the Syllable Repetition and the Sound-Prolonged subtests. A significant univariate effect was found for the syllables and sentences containing nasal consonants and high vowels compared to syllables and sentences containing oral consonants and low vowels. Across all the SNAP Test-R subtests, the females’ nasalance scores were higher than the males. A significant univariate effect was also found across nasal syllables, and high vowels such that the females’ nasalance scores were higher than the males. Tables of normative data are provided that may be useful for clinical purposes.

Conclusion:

Norms obtained demonstrated nasalance score differences according to age and gender, particularly in the Syllable Repetition/Prolonged Sound subtest. These differences were discussed in light of potential reasons for their existence and implications for understanding velopharyngeal function. In addition, nasalance scores are affected by the vowel type and place of articulation of the consonant. These facts should be considered when nasometry is used clinically and for research purposes.
Genetic and Clinical Predictors of Left Atrial Thrombus: A Single Center Case-Control Study
Authors: Springer Adrian , Schleberger Ruben , Oyen Florian , Hoffmann Boris A. , Willems Stephan , Meyer Christian , Langer Florian , Schnabel Renate B. , Kirchhof Paulus , Schneppenheim Reinhard , Lemoine Marc D.
Published: June 2021

Left atrial (LA) thrombus formation is the presumed origin of thromboembolic complications in patients with atrial fibrillation (AF). Beyond clinical risk factors, the factors causing formation of LA thrombi are not well known. In this case-control study, we analyzed clinical characteristics and genetic thrombophilia markers (factor V Leiden (FVL), prothrombin G20210A (FIIV), Tyr2561 variant of von Willebrand factor (VWF-V)) in 42 patients with AF and LA thrombus (LAT) and in 68 control patients with AF without LAT (CTR). Patients with LAT had more clinical conditions predisposing to stroke (mean CHA2DS2-VASc-score 3.4 ± 1.5 vs. 1.9 ± 1.4; P < 0.001), a higher LA volume (96 ± 32 vs. 76 ± 21 ml, P = 0.002) and lower LA appendage emptying velocity (0.21 ± 0.11vs. 0.43 ± 0.19 m/s, P < 0.001). Prevalence of FVL, FIIV and VWF-V mutations was not different, but in the subgroup of patients <65 years (y) there was a tendency for a higher incidence of VWF-V with a prevalence of 27% (LAT <65 y) vs. 7% (CTR <65 y, P = 0.066). These findings warrant further investigation of the VWF-V as a risk factor for LA thrombogenesis in younger patients.
Rotational Thromboelastometry Reveals Distinct Coagulation Profiles for Patients With COVID-19 Depending on Disease Severity
Authors: Gönenli Mehmet Gökhan , Komesli Zeynep , İncir Said , Yalçın Özlem , Akay Olga Meltem
Published: June 2021

Identifying a hypercoagulable state in patients with COVID-19 may help identify those at risk for virus–induced thromboembolic events and improve clinical outcomes using personalized therapeutic approaches. Herein, we aimed to perform a global assessment of the patients’ hemostatic system with COVID-19 using rotational thromboelastometry (ROTEM) and to describe whether patients with different disease severities present different coagulation profiles. Together with 37 healthy volunteers, a total of 65 patients were included and then classified as having mild, moderate, and severe disease depending on clinical severity. Peripheral blood samples were collected and analyzed using a ROTEM Coagulation Analyzer. Also, complete blood count and coagulation parameters including prothrombin time, activated partial thromboplastin time, fibrinogen levels, and D-dimer levels were measured at admission. EXTEM and INTEM MCF ( P < 0.001) values were significantly higher and the EXTEM CFT ( P = 0.002) value was significantly lower in patients with COVID-19 when compared with controls. In particular, patients with the severe disease showed a significant decrease in CFT ( P < 0.001) and an increase in MCF ( P < 0.001) in both INTEM and EXTEM assays compared with patients with the non-severe disease. Correlation analysis revealed significant correlations between ROTEM parameters and other coagulation parameters. There were significant positive correlations between fibrinogen, D-dimer, platelet count, and MCF in both EXTEM and INTEM assays. Our data demonstrate thromboelastographic signs of hypercoagulability in patients with COVID-19, which is more pronounced in patients with increased disease severity. Therefore, ROTEM analysis can classify subsets of patients with COVID-19 at significant thrombotic risk and assist in clinical decisions.
Making the Call: College Students’ Legal Consciousness and Hypothetical Activation of Police for Sexual Assaults
Authors: Oberweis Trish , Henry Dayna , Griner Stacey , Gorislavsky Ekaterina
Published: June 2021

Research has identified the necessity of sexual assault victims to label their experience as criminal to initiate reporting. However, barriers exist in labeling uninvited sexual contact as criminal. This study examined college students’ assessments of whether eight nonconsensual behaviors met the legal definition of sexual assault, and whether such behaviors should be reported to police. Results indicated students acknowledged the nonconsensual behaviors as criminal; however, gaps were identified between awareness that the acts were criminal and willingness to report to police. Findings demonstrate a need for continued efforts for sexual assault prevention among college students.
Testing Classical Predictors of Public Willingness to Censor on the Desire to Block Fake News Online
Authors: Martin Justin D , Hassan Fouad
Published: June 2021

This study examined media use and attitudinal predictors of public willingness to censor fake online political news among representative samples in Lebanon, Saudi Arabia, and Tunisia (total N = 2880). The study utilized research on the corrective action hypothesis (CAH) and the theory of presumed media influence (TPMI) as frameworks. The CAH holds that an individual’s belief that media are hostile and influential increases the likelihood that the individual will participate in public discourse urging countermeasures. TPMI maintains that the belief that media are influential is associated with attitudes about media, though those attitudes need not be negative. Perceived exposure to fake news online positively predicted willingness to censor fake news in all countries, aligning with some prior research on both the CAH and the TPMI. Facebook use was negatively associated with willingness to censor fake news in two of the countries, while trust in news media was a positive correlate in two countries. Implications for research on both willingness to censor and on fake news are discussed.
Reformulating emancipation in the Anthropocene: From didactic apocalypse to planetary subjectivities
Authors: Arias-Maldonado Manuel
Published: June 2021

The ideal of emancipation has been traditionally grounded on the premise that human activity is not restrained by external boundaries. Thus the realisation of values such as autonomy or recognition has been facilitated by economic growth and material expansion. Yet there is mounting evidence that the human impact on natural systems at the planetary level, a novelty captured by the concept of the Anthropocene, endangers the Earth’s habitability. If human development is to be limited for the sake of global sustainability, can emancipation be kept as a mobilising ideal? As opposed to alternative views such as that of degrowth, this article argues that it can. The key lies in the ability of the Anthropocene to produce planetary subjectivities. By recognising the bounded quality of human embeddedness, the possibility of a different emancipation is opened up. The latter does not give up material well-being, yet it makes sure that the latter does not endanger planetary habitability.
Investigation of Candidate Genes and Pathways in Basal/TNBC Patients by Integrated Analysis
Authors: Liu Qi , Song Xiang , Liu Zhaoyun , Yu Zhiyong
Published: June 2021

Purpose:

This study aims to identify the key pathway and related genes and to further explore the potential molecular mechanisms of triple negative breast cancer (TNBC).

Methods:

The transcriptome data and clinical information of breast cancer patients were downloaded from the TCGA database, including 94 cases of paracancerous tissue, 225 cases of Basal like type, 151 cases of Her2 type, 318 cases of Luminal type A, 281 cases of Luminal type B, and 89 cases of Normal Like type. The differentially expressed genes (DEGs) were identified based on the criteria of |logFC|≥1.5 and adjust P < 0.001.Their functions were annotated by gene ontology (GO) analysis and Kyoto Encyclopedia of differentially expressed genes & Genomes (KEGG) pathway analysis. Cox regression univariate analysis and Kaplan-Meier survival curves (Log-rank method) were used for survival analysis. FOXD1, DLL3 and LY6D were silenced in breast cancer cell lines, and cell viability was assessed by CCK-8 assay. Further, the expression of FOXD1, DLL3 and LY6D were explored by immunohistochemistry on triple negative breast tumor tissue and normal breast tissue.

Results:

A total of 533 DEGs were identified. Functional annotation showed that DEGs were significantly enriched in intermediate filament cytoskeleton, DNA−binding transcription activator activity, epidermis development, and Neuroactive ligand−receptor interaction. Survival analysis found that FOXD1, DLL3, and LY6D showed significant correlation with the prognosis of patients with the Basal-like type ( P < 0.05). CCK-8 assay showed that compared with Doxorubicin alone group, the cytotoxicity of Doxorubicin combined with siRNA-knockdown of FOXD1, DLL3, or LY6D was much significant.

Conclusion:

The DEGs and their enriched functions and pathways identified in this study contribute to the understanding of the molecular mechanisms of TNBC. In addition, FOXD1, DLL3, and LY6D may be defined as the prognostic markers and potential therapeutic targets for TNBC patients.
High-precision robotic assembly system using three-dimensional vision
Authors: Yan Shaohua , Tao Xian , Xu De
Published: June 2021

The design of a high-precision robot assembly system is a great challenge. In this article, a robotic assembly system is developed to assemble two components with six degree-of-freedoms in three-dimensional space. It consists of two manipulators, a structured light camera which is mounted on the end-effector aside component A to measure the pose of component B. Firstly, the features of irregular components are extracted based on U-NET network training with few labeled images. Secondly, an algorithm is proposed to calculate the pose of component B based on the image features and the corresponding three-dimensional coordinates on its ellipse surface. Thirdly, the six errors including two position errors and one orientation error in image space, and one position error and two orientation errors in Cartesian space are computed to control the motions of component A to align with component B. The hybrid visual servoing method is used in the control system. The experimental results verify the effectiveness of the designed system.
Online representations of non-canonical sentences are more than good-enough
Authors: Cutter Michael G , Paterson Kevin B , Filik Ruth
Published: June 2021

Proponents of good-enough processing suggest that readers often (mis)interpret certain sentences using fast-and-frugal heuristics, such that for non-canonical sentences (e.g., The dog was bitten by the man) people confuse the thematic roles of the nouns. We tested this theory by examining the effect of sentence canonicality on the reading of a follow-up sentence. In a self-paced reading study, 60 young and 60 older adults read an implausible sentence in either canonical (e.g., It was the peasant that executed the king) or non-canonical form (e.g., It was the king that was executed by the peasant), followed by a sentence that was implausible given a good-enough misinterpretation of the first sentence (e.g., Afterwards, the peasant rode back to the countryside) or a sentence that was implausible given a correct interpretation of the first sentence (e.g., Afterwards, the king rode back to his castle). We hypothesised that if non-canonical sentences are systematically misinterpreted, then sentence canonicality would differentially affect the reading of the two different follow-up types. Our data suggested that participants derived the same interpretations for canonical and non-canonical sentences, with no modulating effect of age group. Our findings suggest that readers do not derive an incorrect interpretation of non-canonical sentences during initial parsing, consistent with theories of misinterpretation effects that instead attribute these effects to post-interpretative processes.
Synthesis, cytotoxicity, and molecular docking of methylated (–)-epigallocatechin-3-gallate-4β-triazolopodophyllotoxin derivatives as novel antitumor agents
Authors: Zi Cheng-Ting , Wang Ze-Hao , Shi Jing , Shi Bo-Ya , Zhang Ning , Wu Yi-Long , Xie Yin-Rong , Zhou Lu , Xiao Chun , Wang Xuan-Jun , Sheng Jun
Published: June 2021

A series of novel methylated (–)-epigallocatechin-3-gallate-4β-triazolopodophyllotoxin derivatives is synthesized by utilizing the click reaction. Evaluation of their cytotoxicity against a panel of five human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW480) using the MTT assay shows that most of these compounds exhibit weak cytotoxicity. It is observed that compound 12 shows the highest activity against A-549 cells with an IC50 value of 10.27 ± 0.90 μM. Molecular docking results suggested that this compound 12 has a higher binding affinity for epidermal growth factor receptor than for tubulin. Our findings support the utility of compound 12 as a novel compound for the further development of anticancer agents.
Effects of supplemental jump and sprint exercise training on sand on athletic performance of male U17 handball players
Authors: Hammami Mehrez , Gaamouri Nawel , Ramirez-Campillo Rodrigo , Aloui Gaith , Shephard Roy J , Hill Lee , Knechtle Beat , Chelly Mohamed Souhaiel
Published: June 2021

This controlled study investigated the effects of 7 weeks pre-season supplemental jump and sprint exercise training on sand (JSETS) on athletic ability in male handball players. Males (n = 40; 16.3 ± 0.4 years) were randomly assigned to a jump and sprint training (JSTG; n = 24) or a control (CG; n = 18) group. The JSETS replaced a part of the regular handball training of players. The tests included jumps (squat, counter-movement, and 5 jump tests), sprint times (5 m, 10 m and 20 m), agility (modified T and modified Illinois tests), repeated sprint T-test, and balance (standing stork and Y balance tests). JSTG showed relative to CG significant decreases in sprint times over all distances (5 m (p = 0.002, d = 0.735 (medium); 10 m (p = 0.012, d = 0.577 (medium) and 20 m (p = 0.012, d = 0.573 (medium)), and gains in both measures of agility (p = 0.001, d = 0.859 (large) and p = 0.004, d = 0.670 (medium) for T-Half and Illinois-tests respectively), and in jumping squat (p < 0.001, d = 0.813 (large)) and countermovement jumping (p = 0.004, d = 0.663 (medium)), but not in the 5-jump test. Three of the four repeated sprint scores (best time (BT), meantime (MT) and total time (TT)) improved significantly (p = 0.012, d = 0.577 (medium); p = 0.042, d = 0.463 (small) and p = 0.043, d = 0.458 (small) respectively), but the decrement (DEC) remained unchanged. The Y balance test showed significant gains in 2 of 3 scores for the right leg and 1 of 3 scores for the left leg, and the stork balance (right leg) was enhanced. In conclusion, compared to regular handball training, supplemental jump and sprint exercise training on sand substantially improved sprinting, agility, jumping, repeated sprinting, and balance in male handball players.
Targeted therapy in SDH-deficient GIST
Authors: Nannini Margherita , Rizzo Alessandro , Indio Valentina , Schipani Angela , Astolfi Annalisa , Pantaleo Maria Abbondanza
Published: June 2021

The medical management of advanced gastrointestinal stromal tumors (GIST) has improved with the development of tyrosine kinase inhibitors (TKIs) targeting KIT and PDGFRA mutations. However, approximately 5–10% of GIST lack KIT and PDGFRA mutations, and about a half are deficient in succinate dehydrogenase ( SDH) that promotes carcinogenesis by the cytoplasmic accumulation of succinate. This rare group of GIST primarily occurs in the younger patients than other subtypes, and is frequently associated with hereditary syndromes. The role of TKIs in patients with SDH-deficient GIST is controversial, with conflicting results; thus, there is an urgent need to uncover the disease mechanisms, treatment patterns, and responses to systemic therapy among these patients. Here, based on an extensive literature search, we have provided a rigorous overview of the current evidence on the medical treatment of SDH-deficient GIST.
Exploring the concept of arbitral awards under the New York Convention
Authors: Kalaitsoglou Konstantina
Published: June 2021

Despite its importance, the arbitral award was left undefined by the New York Convention and most other major international arbitration laws. This has inevitably led to varying opinions regarding its nature and confusion regarding the thresholds that differentiate arbitral awards from other tribunal decisions. Partly in response to the above, there has been discussion to initiate the revising process of the Convention. Responses have been divided. In this paper, the author finds that revision will not bring the desired results, while the Convention itself has equipped international arbitration practice with tools to overcome obscure legal concepts such as the arbitral award.
“Let’s Go, Baby Forklift!”: Fandom Governance and the Political Power of Cuteness in China
Authors: Wong Jamie , Lee Crystal , Long Vesper Keyi , Wu Di , Jones Graham M.
Published: June 2021

This article describes how the Chinese state borrows from the culture of celebrity fandom to implement a novel strategy of governing that we term “fandom governance.” We illustrate how state-run social media employed fandom governance early in the COVID-19 pandemic when the country was convulsed with anxiety. As the state faced a crisis, state social media responded with a propagandistic display of state efficacy, broadcasting a round-the-clock livestream of a massive emergency hospital construction project. Chinese internet users playfully embellished imagery from the livestream. They unexpectedly transformed the construction vehicles into cute personified memes, with Baby Forklift and Baby Mud Barfer (a cement mixer) among the most popular. In turn, state social media strategically channeled this playful engagement in politically productive directions by resignifying the personified vehicles as celebrity idols. Combining social media studies with cultural and linguistic anthropology, we offer a processual account of the semiotic mediations involved in turning vehicles into memes, memes into idols, and citizens into fans. We show how, by embedding cute memes within modules of fandom management such as celebrity ranking lists, state social media rendered them artificially vulnerable to a fall in status. Fans, in turn, rallied around to “protect” these cute idols with small but significant acts of digital devotion and care, organizing themselves into fan circles and exhorting each other to vote. In elevating the memes to the status of celebrity idols, state social media thereby created a disposable pantheon of virtual avatars for the state, and consolidated state power around citizens’ voluntary response to vulnerability. We analyze fandom governance as a new development in the Chinese state’s long history of governing citizens through the management of emotion.
Making Sweet Music Together: The Affordances of Networked Media for Building Performance Capital by YouTube Musicians
Authors: Gruzd Anatoliy , Hodson Jaigris
Published: June 2021

Following Miller, who looked at offline performance capital for musicians and discovered important gender and genre impacts, we examined the role of gender and genre in the development of performance capital for YouTube top cover song artists. This case study suggests that online performance capital on YouTube is slightly different than offline performance capital, and benefits from the affordances of networked media, and specifically YouTube. While there is some gender-based homophily in channel linking behaviors, there are also connections between weakly tied individuals with respect to video category, meaning that musicians are linking to others outside of the music community and vice versa. While music video channels tend to link to other music video channels, and non-music channels tend to link to other non-music channels, the most popular videos tend to post from multiple categories including both music and non-music. Findings suggest that being a long-time poster and having a rich and diverse network are likely elements of building performance capital for YouTube musicians.
The Influence of Motivation, Emotions, Cognition, and Metacognition on Students’ Learning Performance: A Comparative Study in Higher Education in Blended and Traditional Contexts
Authors: Acosta-Gonzaga Elizabeth , Ramirez-Arellano Aldo
Published: June 2021

Previous research has proposed a conceptual model of the relationships between motivation, emotions, cognition, and metacognition related to students’ learning performance and validated it in a blended learning context that combines traditional learning with the use of educational technology. This study examined these relationships to test the hypothesis that the levels of some factors in a face-to-face learning environment differ from those in a blended learning context, finding that the conceptual model is valid for both settings. The role of positive emotions was significant in blended learning but not in face-to-face learning. Furthermore, help-seeking and peer learning were relevant only in blended learning. A positive relationship between academic motivations and metacognitive strategies was found in the face-to-face context, whereas one from motivations to metacognitive and cognitive strategies was found in the blended context. Negative emotions were present in both learning settings. This shows that the role of emotions is relevant to students’ perceived success.
A Systematic Assessment of YouTube Content on Femoroacetabular Impingement: An Updated Review
Authors: Crutchfield Connor R. , Frank Jessie S. , Anderson Matthew J. , Trofa David P. , Lynch T. Sean
Published: June 2021

Background:

Online video-sharing platforms such as YouTube have become popular sources of medical information for patients. However, concern exists regarding the quality of such non–peer reviewed content. In fact, a previous investigation found the majority of YouTube information related to femoroacetabular impingement (FAI) to be of poor quality.

Purpose:

To provide an updated assessment of the quality of FAI-related videos available on YouTube.

Study Design:

Cross-sectional study.

Methods:

The terms FAI, femoroacetabular impingement, and hip impingement were searched on YouTube, and exclusion criteria were applied to the first 100 results for each term. The diagnostic and treatment content of each video was graded and assigned a quality assessment rating based on a previously used rubric. Video characteristics (e.g. duration, views, “likes”) were compared using both quality assessment rating and video source.

Results:

A total of 142 videos were included in the final analysis. The most common video source was educational (48.6%), followed by physician-sponsored (30.3%). The majority of videos were graded as “somewhat useful” for both diagnostic and treatment content (59.4% and 61.6%, respectively); however, treatment content was rated “not useful” more often than diagnostic information (20.3% vs. 8.7%, respectively). Videos rated as “somewhat useful” received the most views per day on average, while educational videos were the most viewed by source (views and views per day). Educational videos had more views and likes on average than physician-sponsored videos ( P < .05), but all other comparisons of video characteristics by source were not significant. Video duration was the only characteristic found to vary significantly by quality assessment rating ( P < .001 for both diagnostic and treatment analyses), with higher-quality videos tending to be longer. Videos rated as “excellent” and “very useful” had mean durations >30 minutes but were viewed the least.

Conclusion:

The overall quality of FAI-related content on YouTube remains low. Clinicians should be familiar with medical information available to patients on the internet, as it can influence patients’ perspectives and shared decision-making processes. This review substantiates the need for more publicly available, high-quality video content regarding the diagnosis and treatment of FAI.
Determinants of Long Immunization Clinic Wait Times in a Sub-Saharan African Country
Authors: Ekhaguere Osayame Austine , Oluwafemi Rosena Olubanke , Oyo-Ita Angela , Mamlin Burke , Bondich Paul , Mendonca Eneida A. , Rollins Angela L.
Published: June 2021

The wait time clients spend during immunization clinic visits in low- and middle-income countries is a not well-understood reported barrier to vaccine completion. We used a prospective, observational design to document the total time from client arrival-to-discharge and all sequential provider-client activities in 1 urban, semi-urban, and rural immunization clinic in Nigeria. We also conducted caregiver and provider focus group discussions to identify perceived determinants of long clinic wait times. Our findings show that the time from arrival-to-discharge varied significantly by the clinic and ranged between 57 and 235 minutes, as did arrival-to-all providers-client activities. Focus group data attributed workflow delays to clinic staff waiting for a critical mass of clients to arrive for their immunization appointment before starting the essential health education talk or opening specific vaccine vials. Additionally, respondents indicated that complex documentation processes caused system delays. Research on clinic workflow transformation and simplification of immunization documentation is needed.
Why Does the ‘Provincial Propertied Class’ Remain Provincial? Reading the Agrarian Question of Capital Through Caste
Authors: Kalaiyarasan A.  , Vijayabaskar M.
Published: June 2021

While labour linkages and flows between rural and urban India have been studied, there is little discussion on the implications of the agrarian question of capital for the urban. This is particularly important given the intertwining of caste and capital accumulation in India. If there are caste barriers to entry into accumulation in the urban, what does it mean for pathways of diversification of agrarian capital out of agriculture? In this article, we address this question by comparing the trajectories of capital accumulation in the urban by two agrarian caste groups, the Kongu Vellala Gounders (KVGs) in western Tamil Nadu and the Jats in Haryana. We argue that the dominance of specific caste groups in non-agrarian accumulation erects barriers for transition of agrarian capital into the urban. Such barriers are further aggravated by the increasingly adverse conditions under which capitalist farmers produce in rural India and by new barriers to entry posed by globalising market conditions. Finally, we suggest that differences in subnational politics account for differences in transition pathways between the two agrarian castes. We therefore argue that a caste-based reading is critical to understand how caste intersects with diversification of capital from the rural to the Indian urban.
The disaster resilience value of shared rooftop solar systems in residential communities
Authors: Patel Siddharth , Ceferino Luis , Liu Chenying , Kiremidjian Anne , Rajagopal Ram
Published: June 2021

Distributed energy resources can enhance community resilience to power outages in the aftermath of natural disasters. This article presents a method to quantify the resilience value that rooftop solar systems can provide to residential neighborhoods. Homes are grouped into geographical clusters to simulate the effect of sharing energy when a disaster disables the electric grid and damages some of the homes. Historical energy consumption and solar irradiance data are used to estimate the likelihood that each cluster could meet its own energy needs, given a defined level and pattern of rooftop solar adoption. As a case study, the method is applied to single-family homes in San Carlos, California, subjected to a disaster scenario representing the 1906 San Francisco earthquake. The case study shows how higher rooftop solar adoption levels increase postearthquake power accessibility during different seasons of the year. It also demonstrates that policy intervention can ensure more geographically uniform solar adoption and, therefore, more even resilience. Finally, the article evaluates the effect and cost of such an intervention, finding that a modest subsidy can make a notable difference in evening out resilience across a community.
Lactiplantibacillus plantarum strains isolated from spontaneously fermented cocoa exhibit potential probiotic properties against Gardnerella vaginalis and Neisseria gonorrhoeae
Authors: das Neves Selis Nathan , de Oliveira Hellen Braga Martins , Leão Hiago Ferreira , dos Anjos Yan Bento , Sampaio Beatriz Almeida , Correia Thiago Macêdo Lopes , Almeida Carolline Florentino , Pena Larissa Silva Carvalho , Reis Mariane Mares , Brito Thamara Louisy Santos , Brito Laís Ferraz , Campos Guilherme Barreto , Timenetsky Jorge , Cruz Mariluze Peixoto , Rezende Rachel Passos , Romano Carla Cristina , da Costa Andréa Miura , Yatsuda Regiane , Uetanabaro Ana Paula Trovatti , Marques Lucas Miranda
Published: June 2021

Background

Probiotics are important tools in therapies against vaginal infections and can assist traditional antibiotic therapies in restoring healthy microbiota. Recent research has shown that microorganisms belonging to the genus Lactobacillus have probiotic potential. Thus, this study evaluated the potential in vitro probiotic properties of three strains of Lactiplantibacillus plantarum, isolated during the fermentation of high-quality cocoa, against Gardnerella vaginalis and Neisseria gonorrhoeae. Strains were evaluated for their physiological, safety, and antimicrobial characteristics.

Results

The hydrophobicity of L. plantarum strains varied from 26.67 to 91.67%, and their autoaggregation varied from 18.10 to 30.64%. The co-aggregation of L. plantarum strains with G. vaginalis ranged from 14.73 to 16.31%, and from 29.14 to 45.76% with N. gonorrhoeae. All L. plantarum strains could moderately or strongly produce biofilms. L. plantarum strains did not show haemolytic activity and were generally sensitive to the tested antimicrobials. All lactobacillus strains were tolerant to heat and pH resistance tests. All three strains of L. plantarum showed antimicrobial activity against the tested pathogens. The coincubation of L. plantarum strains with pathogens showed that the culture pH remained below 4.5 after 24 h. All cell-free culture supernatants (CFCS) demonstrated activity against the two pathogens tested, and all L. plantarum strains produced hydrogen peroxide. CFCS characterisation in conjunction with gas chromatography revealed that organic acids, especially lactic acid, were responsible for the antimicrobial activity against the pathogens evaluated.

Conclusion

The three strains of L. plantarum presented significant probiotic characteristics against the two pathogens of clinical importance. In vitro screening identified strong probiotic candidates for in vivo studies for the treatment of vaginal infections.
Experiences of family caregivers of patients with COVID-19
Authors: Rahimi Tahereh , Dastyar Neda , Rafati Foozieh
Published: June 2021

Background

Family caregivers of patients with COVID-19 face many challenges that affect their physical and mental health.

Aim

The aim of the present study was to explore experiences of family caregivers of patients with COVID-19.

Methods

This phenomenological study was performed based on 13 family caregivers who had experience in home caring for patients with COVID-19. Data were collected through purposive sampling with in-depth semi-structured interviews. The Colaizzi's 7-step method was used to determine themes. The MAXQDA10 software was used to manage qualitative data analysis.

Results

Thirteen family caregivers participated. Five main themes describe family caregivers' experiences of caring for patients with COVID-19: nature of the disease; unmet needs; unpleasant physical, psychological, and social experiences; care facilitators and positive experiences.

Conclusion

Information and financial support for COVID-19 should be provided to family caregivers. Also, community members should embrace patients and family caregivers and reinforce the positive experiences of caregivers.
Association of serum 25-hydroxyvitamin D with metabolic syndrome and type 2 diabetes: a one sample Mendelian randomization study
Authors: Xiao Jing , Lv Jingyi , Wang Shiyu , Zhou Yang , Chen Lunwen , Lu Juying , Zhang Xiaoyi , Wang Xiaojian , Gu Yunjuan , Lu Qingyun
Published: June 2021

Background

Vitamin D deficiency has been associated with type 2 diabetes (T2D) and metabolic syndrome (MS) and its components. However, it is unclear whether a low concentration of vitamin D is the cause or consequence of these health conditions. Thus, this study aimed to evaluate the association of vitamin D concentrations and its genetic risk scores (GRSs) with MS and its component diseases, such as T2D, in middle-aged and elderly participants from rural eastern China.

Methods

A subset of 2393 middle-aged and elderly individuals were selected from 70,458 participants of the Nantong Chronic Diseases Study of 2017–2018 in China. We used two 25-hydroxyvitamin D (25[OH]D) synthesis single-nucleotide polymorphisms (SNPs) (DHCR7-rs12785878 and CYP2R1-rs10741657) and two 25(OH) D metabolism SNPs (GC-rs2282679 and CYP24A1-rs6013897) for creating GRSs, which were used as instrumental variables to assess the effect of genetically lowered 25(OH) D concentrations on MS and T2D based on the Wald ratio. F statistics were used to validate that the four SNPs genetically determined 25(OH) D concentrations.

Results

Compared to vitamin D sufficient individuals, individuals with vitamin D insufficiency had an odds ratio (OR [95% confidence interval {CI}]) of MS of 1.30 (1.06–1.61) and of T2D of 1.32 (1.08–1.64), individuals with vitamin D deficiency had an ORs (95% CI) of MS of 1.50 (1.24–1.79) and of T2D of 1.47 (1.12–1.80), and those with vitamin D severe deficiency had an ORs (95% CI) of MS of 1.52 (1.29–1.85) and of T2D of 1.54 (1.27–1.85). Mendelian randomization analysis showed a 25-nmol/L decrease in genetically instrumented serum 25(OH) D concentrations using the two synthesis SNPs (DHCR7 and CYP2R1 genes) associated with the risk of T2D and abnormal diastolic blood pressure (DBP) with ORs of 1.10 (95%CI: 1.02–1.45) for T2D and 1.14 (95%CI: 1.03–1.43) for DBP.

Conclusions

This one sample Mendelian randomization analysis shows genetic evidence for a causal role of lower 25(OH) D concentrations in promoting of T2D and abnormal DBP in middle-aged and elderly participants from rural China.
Validation of the revised 9-scale clinical frailty scale (CFS) in Greek language
Authors: Vrettos Ioannis , Voukelatou Panagiota , Panayiotou Stefani , Kyvetos Andreas , Kalliakmanis Andreas , Makrilakis Konstantinos , Sfikakis Petros P. , Niakas Dimitris
Published: June 2021

Background

Among many screening tools that have been developed to detect frailty in older adults, Clinical Frailty Scale (CFS) is a valid, reliable and easy-to-use tool that has been translated in several languages. The aim of this study was to develop a valid and reliable version of the CFS to the Greek language.

Methods

A Greek version was obtained by translation (English to Greek) and back translation (Greek to English). The “known-group” construct validity of the CFS was determined by using test for trends. Criterion concurrent validity was assessed by evaluating the extent that CFS relates to Barthel Index, using Pearson’s correlation coefficient. Both inter-rater and test–retest reliability were assessed using intraclass correlation coefficient.

Results

Known groups comparison supports the construct validity of the CFS. The strong negative correlation between CFS and Barthel Index (rs = − 0,725, p ≤ 0.001), supports the criterion concurrent validity of the instrument. The intraclass correlation was good for both inter-rater (0.87, 95%CI: 0.82–0.90) and test-retest reliability (0.89: 95%CI: 0.85–0.92).

Conclusion

The Greek version of the CFS is a valid and reliable instrument for the identification of frailty in the Greek population.
Cigarette smoking may accelerate the progression of IgA nephropathy
Authors: Wang Siqing , Qin Aiya , Pei Gaiqin , Jiang Zheng , Dong Lingqiu , Tan Jiaxing , Tan Li , Tang Yi , Qin Wei
Published: June 2021

Background

Whether cigarette smoking is associated with the progression of immunoglobulin A nephropathy (IgAN) remains uncertain; therefore, we aimed to evaluate the effect of cigarette smoking on the prognosis of IgAN.

Methods

We divided 1239 IgAN patients from West China Hospital of Sichuan University who met the inclusion criteria into smoker (current or former) and non-smoker groups. The endpoint was end-stage renal disease (ESRD: eGFR < 15 mL/min/1.73 m2 or undergoing renal replacement treatment) and/or eGFR decreased by > 50%. Kaplan–Meier, correlation, logistic regression and Cox proportional hazards analyses were performed. The association between cigarette smoking and IgAN was further verified by propensity-score-matched cohort analysis.

Results

During the mean follow-up period of 61 months, 19% (40/209) of the smoker group and 11% (110/1030) of the non-smoker group reached the study endpoint (p < 0.001). Multivariate Cox regression analysis revealed that cigarette smoking (hazard ratio (HR) = 1.58; p = 0.043) was an independent risk factor predicting poor renal progression in IgAN, and that IgAN patients with chronic kidney disease (CKD) stage 3–4 were more susceptible to cigarette smoking (p < 0.001). After propensity score matching (PSM), a significant correlation between cigarette smoking and renal outcomes in IgAN patients was seen. Furthermore, Spearman’s correlation test revealed that smoking dose was negatively correlated with eGFR (r = 0.141; p < 0.001) and positively related with proteinuria (r = 0.096; p = 0.001).

Conclusions

Cigarette smoking is an independent risk factor for IgAN progression, especially for advanced patients.