bluuebunny/crossref_metadata_2025 huggingface dataset:
STXBP5L and its related molecules as potential biomarkers in lymph node metastatic breast cancer
Authors: Gao Guang Yu , Shen Li Qin , Shi Xinya , Yao Zhen , Shen Jiaofeng
Published: March 2020

BackgroundLymph node metastasis is a common problem in breast cancer, and its underlying molecular mechanism is still unclear. The purpose of this study is to research the molecular mechanism and to explore the key RNAs and pathways that mediate lymph node metastasis in breast cancer.MethodsGSE100453 and GSE38167 were downloaded from the Gene Expression Omnibus (GEO) database and 569 breast cancer statistics were also downloaded from the TCGA database. Differentially expressed miRNAs were calculated by using R software and GEO2R. Gene ontology and Enriched pathway analysis of target mRNAs were analyzed by using DAVID and R software. The PPI network was constructed by using Metascape and Cytoscape software.ResultsIn total, 6 differentially expressed miRNAs were selected, and 499 mRNAs were identified after filtering. The research of KEGG indicated that mRNAs enriched in many cancer pathways. Besides, some hub mRNAs were analyzed after constructing the PPI network. A total of 3 out of 6 miRNAs had a significant relationship with the overall survival (P<0.05) and showed a good ability of risk prediction model of over survival.ConclusionBy utilizing bioinformatics analyses, differently expressed miRNAs were identified and constructed a complete gene network. Several potential mechanisms and therapeutic and prognostic targets of lymph node metastasis were also demonstrated in breast cancer.
Island biogeography on a micro-scale: Larger anammox granules not only harbor higher species diversity but also support more functional diversity
Authors: Chen Hui , Liu Tao , Li Jie , Mao Likai , Ye Jun , Han Xiaoyu , Jetten Mike S. M. , Guo Jianhua
Published: March 2020

Background: According to the theory of island biogeography, there is a strong relationship between the species diversity and the isolated area. However, it is unclear whether the ecological distribution of microorganisms follows this island biogeography pattern at micro-scale. Here, we use microbial granules harvested from a partial nitritation and anammox (PN/A) system as a model to test if the microbial and functional diversity follow the island biogeography. We collected and divided these granules into five discrete size-fractions (<0.2, 0.2–0.5, 0.5–0.8, 0.8–1.0 and >1.0 mm).Results: By comparing the composition and functional attribute of five pools of the size-fractionated granules by 16S rRNA gene amplicon, metagenomic and metatranscriptomic sequencing, larger granules were shown not only to harbor higher microbial diversity, but also to support more diverse functions than smaller granules. De novo co-assembly and binning of metagenomic reads yielded 22 near-complete genomes of dominant microorganisms, which allowed us to infer an ecological model of the microbial ecosystem in anammox-based granules. This genome-based ecological model indicates that nitrifying organisms in smaller granules feed nitrite to anammox bacteria in larger granules.Conclusion: Our findings substantiate that microbial communities in PN/A granules follow a species-volume relationship, suggesting the generality of the theory of island biogeography on microscopic scale.
Surface Tension-Based Ultra-Micro Precision Dispensing Method For Micro-Scale Manufacturing
Authors: Fang. Liu Hui , qing Qiao Kai , Xiang Gao Quan , Tian Xu Hao
Published: March 2020

Due to the rapid development of precision micro-manufacturing technology, it has made higher requirements for micro-connection and micro-assembly technologies. An ultra-micro-dispensing method based on the surface tension of the droplets is proposed, which can be realized on the surface of micro-components. Distribute the glue between pl. Use a pipette to pass through the capillary containing the glue, cover the tip of the pipette with glue, and then form tiny glue droplets under the action of the glue's own adhesive force and surface tension. In the experiment, the factors such as the diameter of the pipette, the speed of movement, the Cap value, and the viscosity of the glue were analyzed in detail.Fly upgrade ultra-small dispensing was achieved.The minimum glue droplet was 22.4 μm, and the droplet volume was 228 fL. The planning of the glue droplet trajectory, different plane graphics composed of uniform fl glue droplets, this method achieves precise control of the size and position accuracy of the glue droplets, the deviation of the glue spot diameter is within 2.2 μm, and the deviation of the glue droplet position is 1.58 μm Inside.
Modeling Survival Time to Recovery from COVID-19: A Case Study on Singapore
Authors: Mollazehi Monira , Mollazehi Mohammad , Abdel-Salam Abdel-Salam G.
Published: March 2020

Background: Novel coronavirus (COVID-19) is a new strain of viruses that originated in China. In December 2019, a strange case of pneumonia was reported in Wuhan, which then was diagnosed to be COVID-19. In Singapore, the first positive case was reported on January 23, 2020.Aim: This study aims to study the recovery time from COVID-19 in Singapore between January 23 and March 13, 2020.Methods: It's a retrospective study from January 23 until March 13, 2020 for 187 cases with COVID-19 infection. Data of the instances were collected to identify the factors affecting the recovery time from COVID-19. Several parametric models were fitted and the best predictor model was selected using the Bayesian information criterion (BIC).Results: Out of 187 patients, 96 (51.34%) were cured. The mean (±standard deviation) survival time was 9.40±7.17 days. Based on BIC, the exponential regression model was the weakest and the Weibull model was the best for fitting to data. According to the Weibull model, age (HR=1.01) and nationality (HR=0.76) had significant statistical effects (α=0.05) on patient recovery time.Conclusion: According to the findings of the study, younger patients recover faster compared to elderly patients, and the Singaporean patients cure more quickly than non-Singaporean patients.
Astragalus membranaceus root supplementation improves average daily gain, rumen TVFA production and immunity and antioxidant factors of Tibetan sheep
Authors: Wang Xianju , Ding Luming , Wei Haiyan , Jiang Cuixia , Yan Qi , Hu Changsheng , Jia Gongxue , Zhou Yuqing , Henkin Zalmen , Degen Allan
Published: March 2020

Background: The use of antibiotics as supplements in animal feed is restricted due to possible health hazards associated with them. Consequently, there is increasing interest in exploiting natural products as antibiotics with no detrimental side effects. In this study, we examined the effect of Astragalus membranaceus root (AMT) supplementation on dry matter intake, growth performance, rumen fermentation and immunity of Tibetan sheep. Materials and methods: Twenty-four male Tibetan sheep (31 ± 1.4 kg; 9 months old) were assigned randomly to one of four dietary treatments with different levels of AMT: 0 g/kg, 20 g/kg, 50 g/kg and 80 g/kg dry matter (A 0 , A 2 , A 5 and A 8 , respectively) in addition to their basal diets. A 0 acted as a control group and measurements were recorded over a 56-d feeding period. Results: Sheep fed with AMT had a higher average daily gain (ADG) and a lower feed:gain ratio (F:G) than controls ( P < 0.001). Rumen concentrations of NH 3 -N ( P < 0.001), total volatile fatty acids (TVFA) ( P = 0.028), acetate ( P = 0.017) and propionate ( P = 0.031) in A 5 and A 8 were higher than in A 0 . The addition of AMT in the feed significantly increased serum antioxidant and immunity factors of the sheep and increased the concentrations of serum interleukin, immunoglobulin and tumour necrosis factor-α (TNF-α) ( P = 0.010). Conclusions: We concluded that AMT can be used as a feed additive to improve growth performance and rumen fermentation and enhance the immunity of Tibetan sheep. Some responses exhibited a dose-dependent response, whereas other did not exhibit a pattern, with an increase in AMT. The addition of 50 g/kg and 80 g/kg AMT of total DMI showed the most promising results.
Information Seeking Behavior about Cancer and Associated Factors among Students at DebreTabor University, Ethiopia, 2019: Cross sectional study
Authors: Gedefaw Adugna , Yilma Tesfahun M. , Endehabtu Berhanu F.
Published: March 2020

Introduction The prevalence of cancer has been increasing and it is among the leading cause of death in in sub-Saharan Africa over the last few years which mainly influnced by life-style. Understanding the information seeking behavior of individuals, especially Students who are more likely to seek health information than other people, can be seen as an opportunity to provide resources to improve lifestyle or prevent possible health threatening behaviors among students. The main objective of this study is to determine the health information seeking about cancer among students of Debretabor University Ethiopia.Objective The aim of this study was to assess cancer information seeking behavior (CISB) and its associated factors among students in Debre Tabor University.Methods Institutional based cross-sectional study design was conducted from March 01-30/2019. A total of 844 students were selected using multistage stratified sampling technique. Data entry and analyses were done using Epi info version 7.2 and SPSS version 20 respectively. Descriptive statistics and multivariate logistic regression analyses were applied to determine proportion of cancer information seeking behavior and to identify factors associated.Result The proportion of cancer information seeking by students in the past 12 month was 30.1%. Their first source of information was healthcare providers (48%) followed by Internet (27.6%). The majority 39.8% were looked about breast cancer. Year of study, Internet access (AOR=6.07, 95%CI= 4.05, 9.10), health literacy level (AOR=1.8, 95%CI=1.21, 2.68), self-reported health condition (AOR=1.85, 95% CI=1.25, 2.73), perceived susceptibility to cancer (AOR=2.48, 95% CI=1.47, 4.2) and perceived severity of cancer (AOR=3.33, 95% CI=1.85, 6.0) were the factors associated with cancer information seeking behavior.Conclusion The proportion of cancer information seeking among university students was low. Year of study, internet access, being healthy, health literacy level, level of perception to cancer exposure and perception to severity of cancer were significantly associated with cancer information seeking behavior. Increase health literacy & awareness creation about cancer for students will help to increase cancer information seeking behavior.
Hypolipidemic and antioxidant activities of oil from Antarctic krill (Euphausia superba)
Authors: Zhang Shuo , Chen Li
Published: March 2020

Background: This study aims to determine the hypolipidemic and antioxidant activities of oil from Antarctic krill (AK) (Euphausia superba) in rats.Methods: Thirty-six rats were randomly assigned to three groups fed with diets containing high-fat (HF), AK oil (AKO) or normal fat for 6 weeks.Results: Compared with the HF group, the AKO-diet group had decreased body weight gain, food efficiency ratio, plasma triacylglycerol and total cholesterol but increased faecal fat and cholesterol, plasma low-density lipoprotein cholesterol level and plasma phenoloxidase activity, superoxide dismutase (SOD) activity and glutathione peroxidase activity of rats.Conclusions: These results indicated that AKO is a suitable alternative for hypolipidemic and antioxidant source for humans.
Hand hygiene compliance in Dutch general practice offices: an observational study.
Authors: Hilt Nataliya , Lokate Mariëtte , OldeLoohuis Alfons , Hulscher Marlies EJL , Friedrich Alex W , Voss Andreas
Published: March 2020

Background Hand hygiene (HH) is considered one of the most important measures to prevent healthcare-associated infections (HAI). Most studies focus on HH compliance within the hospital setting, whereas little is known for the outpatient setting. The aim of this study was to evaluate compliance with HH recommendations in general practitioners (GPs) office, based on World Health Organization (WHO) guideline.Methods An observational study was conducted at five Dutch GPs-practices in September 2017. We measured HH compliance through direct observation using WHO’s ‘five moments of hand hygiene’ observation tool. All observations were done by one trained professional.Results We monitored a total of 285 HH opportunities for 30 health care workers (HCWs). The overall compliance was 37%. Hand hygiene compliance was 34%, 51% and 16% for general practitioners, practice assistants, and nurses, respectively. It varies between 63% after body fluid exposure and no HH performance before-, during and after home visit of a patient (defined as moment 5). The preferred method of HH was soap and water (63%) versus 37% for alcohol-based hand rub (ABHR).Conclusions HH compliance among HCWs in Dutch GPs was found to be low, especially with regard to home visits. The WHO recommended switch from hand wash to ABHR was not implemented by the majority of HCWs in 5 observed GPs offices.
Fast delivery of life saving medical supplies in rural areas of Ethiopia
Authors: Znabu Brhanu Fentaw , Begna Lenchio Gudina , Tsegaye Sisay Tamene , Hinaw Debelo Olijira , Negero Amanuel Adem
Published: March 2020

Background: Ethiopia’s maternal mortality rate is among the highest in the world with 470 deaths per 100,000 live births. Every year post-partum hemorrhage (PPH) remains the leading cause of maternal mortality in Ethiopia. The problem is worse in the rural setting where there are not proper facilities and trained health workers to administer injectable medicine. Currently, the methods used by health centers in rural areas include referring the patient to the nearest hospital within a short period of time even though most of patients die in the ambulances without reaching the hospitals in nearby. Method: In this project, the design of rotary-wing unmanned aerial vehicle (UAV) with thermoelectric cold-box system is proposed. The temperature of blood bag is controlled by a thermoelectric cooler working based on the Pieter effect. The blood is transported to rural health centers through UAV, and the blood containing box will release it from higher altitudes using servo dropping mechanism. Results: The prototype was built and undergone through different iteration process. The proposed device was tested for safety, delivery time, bioavailability, range of operation, weight of the package and durability. For this design, the drone was flown a distance of 10km with less than 15 minutes while 100 meters above the ground. Conclusion: The proposed project has a clinical significance such as saving the lives of mothers and the child. Through the design of a UAV, the transportation of medical and biological component is feasible. The use of UAVs for medical supply delivery will considerably reduce the number of people admitting to the hospital and, therefore, minimizes the cost of medical services that comes with hospitalization.
The prognostic utility and clinical outcomes of MNX1-AS1 expression in cancers: a systematic review and meta-analysis
Authors: Li Juan , Jin Wen , Zhang Zhengyu , Chu Jingjing , Yang Hui , Li Chang , Dong Ruiyin , Zhao Cailian
Published: March 2020

Background: Recently, emerging studies have identified that MNX1-AS1 highly expressed among variety of cancers and related with worse prognosis of cancer patients. The purpose of this study was to evaluate the relationship between MNX1-AS1 expression with clinical features and prognosis in different cancers. Methods: In this study, we searched the Web of Science, PubMed, CNKI, and Wanfang databases to find relevant studies of MNX1-AS1. Pooled hazard ratios (HRs) and odds ratios (ORs) with 95% confidence intervals (CIs) were applied to explore the prognostic and clinical significance of MNX1-AS1. Results: A total of 9 literatures were included in this study, including 882 cancer patients. The results showed that patients with increased MNX-AS1 expression were more likely to develop lymph node metastasis (OR = 5.616, 95%CI: 3.093 - 10.199, P = 0.000) and advanced TNM stage (OR = 4.625, 95%CI: 2.366-9.040, P = 0.000). Moreover, we demonstrated that patients with high expression of MNX1-AS1 had poor OS in different cancers (HR = 1.976, 95%CI: 1.653 - 2.361, P=0.000). In addition, patients with high expression of MNX1-AS1 suffer from worse prognosis in gastric cancer (HR = 2.385, 95% CI: 1.838 - 3.094, P = 0.000) and lung cancer (HR= 1.959, 95%CI: 1.353 - 2.835, P = 0.000). Conclusions: High MNX1-AS1 expression is significantly associated with unfavorable clinical outcomes and it has the potential to serve as a prognostic biomarker in cancer patients.
The Efficacy of topical Capsaicin in the management of painful diabetic peripheral neuropathy: A unicenter double-blind, randomized clinical trial
Authors: Agoons Batakeh Ba , Dehayem Mesmin , Etoga Martine Claude Etoa , Agoons Dayawa Da , Yepnjio Faustin , Boli Anne Ongmeb , Wasnyo Yves Florent , Katte Jean-Claude Njabou , Ngassam Eliane Stella Tcheundjio , Nkamgna Ariane , Eugène Sobngwi , Mbanya Jean-Claude
Published: March 2020

Background: Painful peripheral neuropathy is a common complication of diabetes and its management is difficult. Neurotropic drugs, which are the drugs of choice, have moderate efficacy due to high first pass metabolism. Topical Capsaicin, derived from the capsicum plant, is effective in relieving the pain of diabetic peripheral neuropathy in Caucasians. Due to an intercultural bias in pain treatment response, we evaluated the efficacy of Capsaicin on painful diabetic neuropathy in sub-Saharan subjectsMethods: 22 subjects with type 2 diabetes having painful diabetic polyneuropathy were randomly assigned using a 1:1 blocking pattern, with parallel design, to an intervention group of capsaicin cream, or to a control group of Miconazole cream. Participants and investigators were blinded to the randomization. Both groups applied the supplied drug topically three times daily for 08 weeks. Pain intensity was noted in both groups, using a visual analogue scale, at intervals of 2 weeks. The trial took place at the national obesity center in Cameroon. The primary analysis was intention-to-treat, and compared the reduction in the mean pain score from baseline, per 2 week period.Results: Twenty-two patients, aged 55 ± 7 years, with an average pain intensity of 6.3 units in the Capsaicin group and 5.8 units in the placebo group were included; at inclusion, there was no significant difference in the 2 groups (p=0.52). After 02 weeks, the mean value of pain intensity was 3.3±0.9 vs 5.4±1.7 (p=0.004), at week 4, 3.2±0.9 vs 4.7±1.2 (p=0,015), at week 6, 3.5±1.3 vs 4.8±1.3 (p=0.018) and at week 8, 6.6±1.1 vs 5.4±1.0 (p=0.55) for capsaicin and placebo respectively. The main side effect in the capsaicin group was burning sensations in the application zonesConclusion: Capsaicin significantly reduced neuropathic pain in the intervention group; however the pain worsened at week 8. It therefore has a transient positive effect on neuropathic pain in sub-Saharan subjects
Risk factors for esophagojejunal anastomotic leakage in curative total gastrectomy combined with D2 lymph node dissection for gastric cancer: A retrospective cohort study
Authors: Xing Jiadi , Liu Maoxing , Qi Xinyu , Yu Jianhong , Fan Yingcong , Xu Kai , Gao Pin , Tan Fei , Yao Zhendan , Zhang Nan , Yang Hong , Zhang Chenghai , Cui Ming , Su Xiangqian
Published: March 2020

Background This study aimed to explore the risk factors associated with esophagojejunal anastomotic leakage (EJAL) in curative total gastrectomy combined with D2 lymph node dissection for gastric cancer. Methods Consecutive patients receiving Roux-en-Y esophagojejunostomy reconstruction after surgery were reviewed. Multivariate analysis was performed using a logistic regression model to identify independent risk factors for EJAL. Results Of the 390 patients enrolled in this study, EJAL occurred in 10 patients (2.6%). One patient (1/10) with EJAL died. Univariate analysis identified age ( P = 0.025), alcohol consumption ( P = 0.019), pulmonary insufficiency ( P = 0.049), and intraoperative blood loss ( P = 0.015) as risk factors for EJAL. Of these four risk factors, age ( P = 0.043) and alcohol consumption ( P = 0.043) were retained as independent risk factors by multivariate analysis. Conclusions Surgeons should be very careful about anastomotic leakage during the perioperative period, especially in patients with advanced age and a history of alcohol consumption. Pulmonary insufficiency and intraoperative blood loss, although not being identified as independent risk factors, should also be considered.
Feasibility study of a verification method for proton and carbon ion radiotherapy plan delivery accuracy check
Authors: zhao jun , Chen Zhi , Wu Xianwei , Xing Ying , Li Yongqiang
Published: March 2020

Background All plan verification systems available for particle therapy are designed for pre-treatment verification. The plan delivery accuracy during treatment are unknown. The purpose of this study is to introduce a verification method and develop a software for proton and carbon ion plan delivery accuracy check. Methods A program was developed using Matlab to reconstruct dose from beam parameters recorded in log files and compare the dose reconstructed with the dose calculated by treatment planning system (TPS). Ten carbon ion plans and ten proton plans were enrolled in this study for algorithm validation, sensitivity analysis and plan delivery verification. The dose reconstruction algorithm was validated by comparing the dose calculated by TPS with reconstructed dose using the same beam parameters. The sensitivity of gamma pass rate to spot size deviation, position deviation and particle number deviation were analyzed by comparing dose reconstructed from pseudo plans which have manually added errors with original plan dose. Then plan delivery verification using homemade software were done for the 20 actual treated plans. Results A program for plan delivery verification was developed. For the validation of dose reconstruction algorithm, the mean dose difference between reconstructed dose and plan dose were 0.70% ± 0.24% and 0.51% ± 0.25% for carbon ion and proton plans, respectively. According to our simulation, the Gamma pass rate of carbon ion beam is more sensitive to spot position deviation and particle number deviation, and the Gamma pass rate of proton beam is more sensitive to spot size deviation. For the actual plan delivery verification using homemade software, the mean gamma pass rate were 99.47% ± 0.48%, 99.36% ± 0.50% and 99.48% ± 0.50% for carbon ion beams and 99.92% ± 0.13%, 99.96% ±0.06% and 99.89% ±0.13% for proton beams at three different depth of high dose region using 3mm/3% criteria. Conclusions A software was programed and the algorithm was verified. The method we introduced and the software we made for plan delivery verification is feasible and reliable. The verification method presented in this study can be easily repeated in other hospital.
Living with Frailty - What Healthcare Issues Matter to an Older Person? A Focus Group Study
Authors: Author) Kathryn Tipping(Former Corresponding , New Asangaedem Akpan
Published: March 2020

Background The study set out to interview older people with frailty and find out what healthcare issues matter to them. Older people with frailty are an important population subgroup. In the United Kingdom, over 65s already outnumber under 16s, and this is expected to increase. Research into health issues has been undertaken by the International Consortium for Health Outcomes Measurement (ICHOM) and this study builds on that. Recent research has been undertaken in America into health issues. However, these studies were not specifically focused on older people. Methods A scoping review of the literature was undertaken to highlight any gaps in this area of research. Thereafter a focus group interview was carried out with six older people with frailty. Qualitative research often uses smaller samples than quantitative research 7 . Braun and Clarke recommend that for a small project, such as this one, 6-10 interviews should be held. Braun and Clarke state that smaller groups (three to eight participants) work best in terms of generating a rich discussion and have the added benefit of being easier to manage 7 . The six participants were aged 65 years and over and had mild to moderate frailty using the Rockwood Clinical Frailty Scale. 8 The interview was recorded and transcribed, analysed and themes identified. Results The eight themes identified were trust in medical professionals, vulnerability of being an older person in hospital, polypharmacy and wastage of medication, discharge planning and co-ordination of care at home, taking responsibility for your own health, nomenclature, autonomy and falls. Conclusion This study has identified themes to raise awareness among health care professionals about what health issues matter to older people with frailty. The study findings will provide an opportunity for meaningful discussions around what is needed to meet these preferred health issues.
Comparison of efficacy and visual quality after CWFG-FS-LASIK, AF-FS-LASIK and SMILE for correcting myopia with asymmetry mid-to-high astigmatism
Authors: Zhao Zhongxiu , Zhu Miaomiao , Jian Qian , Liu Xialu , Ma Pingting , Li Ping , Peng Yanli
Published: March 2020

Background The individualized ablation is not only able to correct corneal low-order aberrations but also improve the corneal high-order aberrations in corneal asymmetry patients. In this study, we compared the effect of patients with mid-to-high astigmatism asymmetric corneas (1-4D) after three different surgical methods: Selective coma guidance femtosecond Laser in-situ keratomileusis (CWFG-FS-LASIK),Aberration-Free femtosecond Laser in-situ keratomileusis (AF-FS-LASIK) and Small incision lenticule (SMILE).Methods One hundred and fourteen eyes from 58 patients were enrolled in the retrospective study. We measured and compared the best corrected visual acuity (BCVA), uncorrected visual acuity (UCVA), residual astigmatism, total coma, vertical coma (Z3-1), horizontal coma (Z31), Modulation Transfer Function (MTF) and Point Spread Function (PSF) at preoperation and postoperation after three months.Results Visual acuity of patients in three groups was increased after surgeries, but the improvements of visual acuity and residual astigmatism among them were no significant differences. However, the improvements of 4mm and 6mm total coma, Z3-1 and Z31 in CWFG-FS-LASIK were superior than in AF-FS-LASIK and SMILE. Consistent with this, the improvements of MTF and PSF (3mm and 5mm) in CWFG-FS-LASIK were better than in AF-FS-LASIK and SMILE.Conclusions In surgeries for treating patients with mid-to-high astigmatism in asymmetric corneas, the selective coma-guided mode was able to decrease the coma of original cornea, improve visual acuity and optimize the visual quality of patients.
Viral and host factors related to the clinic outcome of the SARS-CoV-2 infection
Authors: Zhang Xiaonan , Tan Yun , Ling Yun , Lu Gang , Liu Feng , Yi Zhigang , Jia Xiaofang , Wu Min , Shi Bisheng , Xu Shuibao , Chen Jun , Wang Wei , Chen Bing , Jiang Lu , Yu Shuting , Lu Jing , Wang Jingzheng , Xu Mingzhu , Yuan Zhenghong , Zhang Qin , Zhang Xinxin , Zhao Guoping , Wang Shengyue , Chen Saijuan , Lu Hongzhou
Published: March 2020

At least three months have been passed since the outbreak of the severe acute respiratory disease, COVID-19 in Wuhan city, China in December 2019, caused by the infection of a novel coronavirus, SARS-CoV-2.1,2. Due to its rapid spread throughout China and abroad, knowledge sharing for both its epidemiology and clinic manifestations is urgently need. Here we analyzed the clinical, molecular and immunological data from 326 confirmed cases of SARS-CoV-2 infection in Shanghai. Genomic sequences assembled from 112 quality samples together with uploaded sequences in Global Initiative on Sharing All Influenza Data (GISAID) showed a stable evolution and suggested two major lineages with differential exposure history during the earliest outbreak in Wuhan. Nevertheless, they exhibited similar virulence and clinical outcomes. Lymphocytopenia, especially the reduced CD4+ and CD8+ T cell counts upon admission, was predictive of disease progression. High level of IL-6 and IL-8 during treatment was observed in severe and critical patients and correlated with decreased lymphocyte count. The determinants of disease severity seemed to stem mostly from host factors such age, lymphocytopenia and its associated cytokine storm whereas viral genetic variation did not significantly affect the outcomes. This comprehensive analysis on the molecular, immunological and clinical data provides a panorama of the key determinants related to the disease outcomes which should be helpful for improving the current combat against this extremely aggressive pandemic.Authors Xiaonan Zhang, Yun Tan, Yun Ling, Gang Lu, Feng Liu, and Zhigang Yi contributed equally to this work.
Exploring financial parameters and innovative orientation of banks as criteria for selecting financial partners for enterprises
Authors: M. Hutsaliuk Oleksii , V. Yaroshevska Oksana , Yu. Kotsiurba Olha , S. Navolokina Alla
Published: March 2020

The article substantiates aspects that are fundamental for the economic justification of the bank selection by enterprises as the main stage in the partnership formation. It also defines the development of a bank selection procedure taking into account the financial parameters and innovative orientation of banks.The proposed procedure for selecting banks includes two blocks. The first block is the comparison of banks in terms of reliability, which is determined based on indicators for assessing their financial risks and confidence of enterprises. The second block is the comparison of the most reliable banks according to the operational capabilities of Internet banking systems (in terms of functionality) and the intensity of promotion of innovative products and services that meet the needs of enterprises.The proposed bank selection procedure is mainly based on applying the classification functions that allow the reliability-based differentiation as well as comparison of banks. The proposals submitted with the aim to develop classification functions, as well as the bank selection procedure as a whole, were tested based on the financial statements and general information on the Ukrainian banks’ activity as of January 1, 2019. The following results were obtained while testing the developed procedure: It defines the features specific to dividing the analyzed Ukrainian banks into groups (70% are high-reliability banks, 7% are medium-reliability banks, and 23% are low-reliability banks). It also highlights the fact that reliable banks are focused on innovating and developing remote services for their business clients.
Combating crime in the banking sector as a method for ensuring its stability (evidence from Ukraine)
Authors: Klochko Alyona , Kvasha Oksana , Zahynei Zoia , Logvinenko Mykola , Kurylo Mykola
Published: March 2020

An effective system for combating banking crimes can ensure the stability of the Ukrainian banking sector. Developing such a system requires an analysis of public policy institutional instruments to counter threats to the banking system stability. The article proposes the crime counteraction concept for the Ukrainian banking system based on the analysis of scientific articles dealing with the issue, relevant provisions of legal acts and on the study of functions of law enforcement agencies, individual executive bodies, central public authorities, state collegial bodies, territorial NBU departments, Ukrainian banks and their branches, the Deposit Guarantee Fund, international institutions, and bank clients.It has been established that the stability of the Ukrainian banking system can be ensured by effective interaction of all actors in combating crime in the banking business. Overlapping of their functions and some conflict rules negatively affect ensuring the banking system stability by entities engaged in banking crime counteraction. Therefore, an algorithm of cooperation between relevant counteraction entities should be developed and reflected in the Banking and Financial Security Strategy on the legislative level. Optimization of statistical reporting on crime in the Ukrainian banking sector in a more informative format requires data on both individual types of banking crimes and on the persons who commit them. As part of the work of the National Bank of Ukraine’s Public Council, it is necessary to organize regional public councils and ensure cooperation between bank clients and local banking institutions. It is assumed that the development of effective mechanisms for protecting rights and legitimate interests of depositors and creditors, as well as combating criminalization in the banking sector will be the main functions of these regional public councils. The relevant innovations require amendments to the Regulation on the NBU Public Council.
AcknowledgmentThe article was prepared as part of a project for young scientists of Ukraine in 2017 (state registration number – 0117 U 006531), Improving the Legislation of Ukraine Regarding the Protection of Banking Activities in the Context of European Integration: Economic and Legal Aspect, by Alyona M. Klochko, Ph.D. (Law), Sumy National Agrarian University, Head of the Chair of International Relations.
Wobbly Hedgehog Syndrome (WHS): a review of knowledge and some practical suggestions about differential diagnosis
Authors: RUSZKOWSKI JAKUB J.
Published: March 2020

With increase in popularity of African pygmy hedgehogs kept as pets, veterinarians have a chance of getting more information about housing requirements and diseases of the species. Wobbly Hedgehog Syndrome (WHS) and various neoplasms have been detected frequently. Diagnostic procedures for differentiating nervous system diseases in hedgehogs are still being developed and the prevalence of different diseases seems to be depended on the genetic origin of an animal. The main goal of the article was to review of published data, compare the prevalence of diseases and pathological findings. There is still a need to establish good diagnostic schemes for a check-up examination to detect early stage of the diseases.
FATORES ASSOCIADOS A ALTERAÇÕES DA MICROBIOTA NO TRATO GENITAL FEMININO INFERIOR
Authors: Oliveira Jennefer Aparecida Gonçalves
Published: March 2020

A vagina é colonizada por diversos microrganismos vivendo em equilíbrio e é conhecida por microbiota, ela é composta por: fungos, peptococcos e bactérias aeróbicas e anaeróbicas facultativas comensais, com predominância de lactobacilos. A microbiota desempenha um papel fundamental na manutenção e preservação da saúde, sua composição varia durante a vida da mulher por diversos fatores como a idade, hormônios, e período do ciclo menstrual.  Entretanto diversos fatores são associados a alterações da microbiota e ocasional patologia. O presente trabalho visa avaliar quais os fatores extrínsecos são associados a alterações da microbiota vaginal. Este estudo é uma revisão de literatura integrativa, método apontado por Cooper, onde resultados primários de pesquisas são reunidos a fim de explicar um fenômeno mais abrangente e interconectar elementos isolados Concluímos que fatores como relações frequentes, gestações, medicamentos, sabonetes vaginais e DIU afetam a frequência e a gravidade das alterações da microbiota vaginal. Verificamos também a necessidade de atenção redobrada na saúde pública para com mulheres imunussupremidas, submetidas à quimioterapia, gestantes e mulheres menopausadas. Pois foi encontrado associação entre medicamentos e alterações hormonais com o aumento de alterações de microbiota.  Outro fator associação mudanças da microbiota é o uso de DIU e vaginose bacteriana com alterações de microbiota vaginal, essa informação é relevante para decisões médicas de saúde e para avaliação do seguimento das mulheres em uso de DIU e que medidas de saúde coletivas devem ser tomadas, a fim de minimizar a acompanhar mulheres com alterações de flora ou com algum fator que possa ocasionar as alterações de microbiota.
Radiation shielding swing door drive control system for linear accelerator bunkers
Authors: Kurkiewicz Jarosław , Salwa Michał , Majewska Anna , Żyłka Leszek , Kuciak Andrzej
Published: March 2020

The paper aims to describe a functional radiation shielding door control system as designed and manufactured by the National Centre for Nuclear Research in Otwock, Poland. Basic principles and normative references as well as a short historical overview of control approaches are described.
Anoxic-biocathode microbial desalination cell as a new approach for wastewater remediation and clean water production
Authors: Perazzoli Simone , de Santana Neto José Pedro , Soares Hugo M.
Published: March 2020

Bioelectrochemical systems are emerging as a promising and friendly alternative to convert the energy stored in wastewater directly into electricity by microorganisms and utilize it in situ to drive desalination. To better understand such processes, we propose the development of an anoxic biocathode microbial desalination Cell for the conversion of carbon- and nitrogen-rich wastewaters into bioenergy and to perform salt removal. Our results demonstrate a power output of 0.425 W m−3 with desalination, organic matter removal and nitrate conversion efficiencies of 43.69, 99.85 and 92.11% respectively. Microbiological analysis revealed Proteobacteria as the dominant phylum in the anode (88.45%) and biocathode (97.13%). While a relatively higher bacterial abundance was developed in the anode chamber, the biocathode showed a greater variety of microorganisms, with a predominance of Paracoccus (73.2%), which are related to the denitrification process. These findings are promising and provide new opportunities for the development and application of this technology in the field of wastewater treatment to produce cleaner water and conserve natural resources.
APRESENTAÇÃO
Authors: Lima Clóvis Ricardo Montenegro de
Published: March 2020

Apresentação
O PROBLEMA DA IDENTIDADE NAS TECNOLOGIAS DA INFORMAÇÃO E COMUNICAÇÃO
Authors: Galvão Cleyton Leandro
Published: March 2020

Uma das questões mais difíceis de discernir no âmbito do uso das TICs é decidir o que seria aquilo que chamamos de identidade. Há termos que se referem a partes ou momentos específicos da identidade nas TICs, tanto ao uso quanto ao desenvolvimento que essas identidades podem ter em relação ao envolvimento do usuário. Deste modo, afirmamos que existe uma forma de compreender a identidade no uso das TICs como tentativa de se livrar deste emaranhado de termos e conceitos dispersos que parte da análise do progresso que as tecnologias da informação e comunicação tiveram desde a introdução em massa dos computadores pessoais e a expansão das redes sociais. Assim, será exposto o modo como a identidade passa da fase digital, para fase virtual, para a fase de identidade pessoal online, e por fim se tornando restos digitais.
CONSELHO PROFISSIONAL DE ARQUIVOLOGIA: percepção dos arquivistas sobre a sua criação
Authors: Sobral Natanael Vitor , Lessa Paulo Roberto Meireles da Silva
Published: March 2020

Buscou analisar as percepções dos profissionais arquivistas sobre a elaboração de um Conselho Profissional de Arquivologia em âmbito nacional. Sobre os procedimentos metodológicos, distinguem-se as seguintes etapas: 1) Levantamento de literaturas bibliográficas; 2) Pesquisa documental sobre os Conselhos de Classe; 3) Desenvolvimento e aplicação de um questionário com o propósito de conhecer as percepções dos Arquivistas acerca do assunto. Após os envios eletrônicos, obtiveram-se 43 questionários respondidos; 4) Análise das informações obtidas no questionário. Enquanto principais resultados, percebeu-se, que: 95,3% dos entrevistados são a favor de um Conselho Profissional de Arquivologia, enquanto 4,7% não tem uma opinião formada sobre o tema. Dentre os principais pontos positivos para a criação de um Conselho, destacaram-se: impedir que ocorra o exercício ilegal da profissão; e ter uma representação política da classe. Sobre os negativos, sobressaíram-se: possibilidade de baixo índice de associativismo, dada a baixa quantidade de profissionais formados; e pagar anuidade e encargos.
ÉTICA EM ORGANIZAÇÃO DO CONHECIMENTO: categorização de termos fronteiriços em relação a gênero e sexualidade.
Authors: Pinho Fabio Assis , Milani Suellen Oliveira
Published: March 2020

Trata-se de uma pesquisa exploratória e documental sobre ética na organização do conhecimento que utiliza como escopo empírico um conjunto de termos considerados fronteiriços em relação a gênero e sexualidade. Para tanto, o objetivo foi categorizar termos considerados fronteiriços na questão de gênero e sexualidade, no intuito de formar uma base léxica para averiguar suas condições de organização do conhecimento, particularmente por ser uma reflexão ética. Dessa forma, os corpora investigativos foram 35 termos fronteiriços em relação a gênero e sexualidade encontrados nos artigos científicos publicados na Journal of Homosexuality, Sexualities e Journal of Gay & Lesbian Mental Health, entre os anos de 2010 a 2019. Esses termos fronteiriços foram classificados utilizando o PMEST e o metafiltro. Os resultados demonstraram que o percurso metodológico foi promissor para classificação ética de termos considerados fronteiriços, promovendo um adequado resultado a partir dos aspectos epistêmicos de seus conceitos.
Annona Genus: Traditional Uses, Phytochemistry and Biological Activities
Authors: Leite Débora O. D. , de F. A. Nonato Carla , Camilo Cicera J. , de Carvalho Natália K. G. , da Nobrega Mário G. L. A. , Pereira Rafael C. , da Costa José G. M.
Published: March 2020

Species from the Annona (Anonaceae) genus are used in traditional medicine for the treatment of various diseases. Ethnobotanical studies provide information regarding the plant part and the preparation method being used, while scientific studies such as in vitro, in vivo, and clinical tests can provide evidence supporting ethnopharmacological reports, directing studies towards the isolation of compounds which may be active for specific pathologies. Annona muricata and Annona squamosa were the most commonly reported species from those studied, with Annona cherimola and Annona classiflora also standing out. Acetogenins were the most commonly isolated metabolite class due to their cytotoxic properties, with flavonoids, alkaloids, steroids, and peptides also being reported. Many species from the Annona genus have proven biological activities, such as antitumor, antioxidant, antimicrobial and antifungal. The present review had as its objective to facilitate access to ethnobotanical, chemical and biological information in order to direct future researches.
Recent Studies on Aromatase and Sulfatase Involved in Breast Cancer and their Inhibitors
Authors: Makar Subhajit , Ghosh Abhrajyoti , Kumar Ashok , Singh Sushil K.
Published: March 2020

Enzyme aromatase uses several androgen substrates for the biosynthesis of estrogen, i.e.
conversion of androstenedione to estrone and testosterone to biologically potent estradiol. Aromatase
inhibitors (AIs) such as anastrozole, letrozole and exemestane have been established in standard endocrine
therapy of breast cancer, by interfering with estrogen signaling cascade. Steroid sulphatase
(STS) regulates the level of active oestrogens and androgens in human target organs and
steroidogenic tissues, which have a key role in hormone dependent breast cancers (HDBC). Sulfatase
is still under the exploration stage and is yet to emerge as a potential therapeutic target in
breast cancer. The discovery of estrone 3-O-sulfamate (EMATE), a highly potent irreversible STS
inhibitor, accelerated the development of potent steroidal and nonsteroidal STS inhibitors. Attempts
are also being made for the development of dual inhibitors of AI and STS, as an alternative approach
to overcome the acquired resistance. This review includes the molecular structures and biochemistry
of aromatase and sulphatase enzymes. The advances in the development of inhibitors of the two enzymes
have also been outlined.
The Expression of Hormone Receptors as a Gateway toward Understanding Endocrine Actions in Female Pelvic Floor Muscles
Authors: Castelán Francisco , Cuevas-Romero Estela , Martínez-Gómez Margarita
Published: March 2020

Objective:

To provide an overview of the hormone actions and receptors expressed in the
female pelvic floor muscles, relevant for understanding the pelvic floor disorders.

Methods:

We performed a literature review focused on the expression of hormone receptors mainly in
the pelvic floor muscles of women and female rats and rabbits.

Results:

The impairment of the pelvic floor muscles can lead to the onset of pelvic floor dysfunctions,
including stress urinary incontinence in women. Hormone milieu is associated with the structure and
function alterations of pelvic floor muscles, a notion supported by the fact that these muscles express
different hormone receptors. Nuclear receptors, such as steroid receptors, are up till now the most investigated.
The present review accounts for the limited studies conducted to elucidate the expression of
hormone receptors in pelvic floor muscles in females.

Conclusion:

Hormone receptor expression is the cornerstone in some hormone-based therapies, which
require further detailed studies on the distribution of receptors in particular pelvic floor muscles, as
well as their association with muscle effectors, involved in the alterations relevant for understanding
pelvic floor disorders.
An Efficient Machine Learning Model for Prediction of Acute Myocardial Infarction
Authors: M. Dhilsath Fathima , Samuel S. Justin , Hariharan R.
Published: March 2020

Aim:

This proposed work is used to develop an improved and robust machine learning
model for predicting Myocardial Infarction (MI) could have substantial clinical impact.

Objectives:

This paper explains how to build machine learning based computer-aided analysis system for an early and accurate prediction of Myocardial Infarction (MI) which utilizes framingham heart study dataset for validation and evaluation. This proposed computer-aided analysis model will support medical professionals to predict myocardial infarction proficiently.

Methods:

The proposed model utilize the mean imputation to remove the missing values from the
data set, then applied principal component analysis to extract the optimal features from the data set
to enhance the performance of the classifiers. After PCA, the reduced features are partitioned into
training dataset and testing dataset where 70% of the training dataset are given as an input to the
four well-liked classifiers as support vector machine, k-nearest neighbor, logistic regression and decision
tree to train the classifiers and 30% of test dataset is used to evaluate an output of machine
learning model using performance metrics as confusion matrix, classifier accuracy, precision, sensitivity,
F1-score, AUC-ROC curve.

Results:

Output of the classifiers are evaluated using performance measures and we observed that
logistic regression provides high accuracy than K-NN, SVM, decision tree classifiers and PCA performs
sound as a good feature extraction method to enhance the performance of proposed model.
From these analyses, we conclude that logistic regression having good mean accuracy level and
standard deviation accuracy compared with the other three algorithms. AUC-ROC curve of the proposed
classifiers is analyzed that logistic regression exhibits good AUC-ROC score, i.e around 70%
compared to k-NN and decision tree algorithm.

Conclusion:

From the result analysis, we infer that this proposed machine learning model will act as an optimal decision making system to predict the acute myocardial infarction at an early stage than an existing machine learning based prediction models and it is capable to predict the presence of an acute myocardial Infarction with human using the heart disease risk factors, in order to decide when to start lifestyle modification and medical treatment to prevent the heart disease.