bluuebunny/crossref_metadata_2025 huggingface dataset:
Does Methyl Jasmonate Effectively Protect Plants under Heavy Metal Contamination? Fatty Acid Content in Wheat Leaves Exposed to Cadmium with or without Exogenous Methyl Jasmonate Application
Authors: Repkina Natalia , Murzina Svetlana A. , Voronin Viktor P. , Kaznina Natalia
Published: March 2023

The effect of methyl jasmonate (MJ) (1 µM) on wheat (Triticum aestivum L. cv. Moskovskaya 39), seedlings and the fatty acid (FA) content of leaves under optimal and cadmium (Cd) (100 µM) stress conditions wasinvestigated. Height and biomass accumulation was studied traditionally; the netphotosynthesis rate (Pn) was studied using a photosynthesis system, FAs’profile—GS-MS. No effect on the height and Pn rate of the MJ pre-treatment wheat at optimum growth conditions was found. MJ pre-treatment led to a decrease in the total amount of saturated (about 11%) and unsaturated (about 17%) identified FAs, except α-linoleic FA (ALA), which is probably associated with its involvement in energy-dependent processes. Under Cd impact, the MJ-treated plants had a higher biomass accumulation and Pn rate compared to untreated seedlings. Both MJ and Cd caused stress-induced elevation of palmitic acid (PA) versus an absence of myristic acid (MA), which is used for elongation. It is suggested that PA participates in alternative adaptation mechanisms (not only as a constituent of the lipid bilayer of biomembrane) of plants under stress. Overall, the dynamics of FAs showed an increase in the saturated FA that is important in the packing of the biomembrane. It is supposed that the positive effect of MJ is associated with lower Cd content in plants and a higher ALA content in leaves.
Aquaporin-9 in the Brain Inflammatory Response: Evidence from Mice Injected with the Parkinsonogenic Toxin MPP+
Authors: Zahl Soulmaz , Skauli Nadia , Stahl Katja , Prydz Agnete , Frey Mina Martine , Dissen Erik , Ottersen Ole Petter , Amiry-Moghaddam Mahmood
Published: March 2023

More than 20 years have passed since the first demonstration of Aquaporin-9 (AQP9) in the brain. Yet its precise localization and function in brain tissue remain unresolved. In peripheral tissues, AQP9 is expressed in leukocytes where it is involved in systemic inflammation processes. In this study, we hypothesized that AQP9 plays a proinflammatory role in the brain, analogous to its role in the periphery. We also explored whether Aqp9 is expressed in microglial cells, which would be supportive of this hypothesis. Our results show that targeted deletion of Aqp9 significantly suppressed the inflammatory response to the parkinsonian toxin 1-methyl-4-phenylpyridinium (MPP+). This toxin induces a strong inflammatory response in brain. After intrastriatal injections of MPP+, the increase in transcript levels of proinflammatory genes was less pronounced in AQP9−/− mice compared with wild-type controls. Further, in isolated cell subsets, validated by flow cytometry we demonstrated that Aqp9 transcripts are expressed in microglial cells, albeit at lower concentrations than in astrocytes. The present analysis provides novel insight into the role of AQP9 in the brain and opens new avenues for research in the field of neuroinflammation and chronic neurodegenerative disease.
Aerodynamic Evaluation of Flapping Wings with Leading-Edge Twisting
Authors: Yang Lung-Jieh , Joseph Vivek Jabaraj , Lo Yuan-Lung , Tang Wen-Tzu , Esakki Balasubramanian , Kompala Saravana , Veeranjaneyulu Paritala
Published: March 2023

The purpose of the current study is to emphasize the characteristics and phenomena of leading-edge twisting in flapping wing vehicles. A fused deposition modeling (FDM) 3D printing method is applied to develop the flapping mechanisms with bevel gears to achieve the leading-edge twisting. Three flapping mechanisms were developed, including simple flapping only (type-A1: normal servo mechanism), flapping with continuous leading-edge twisting (type-B: servo-bevel gear mechanism), and flapping with restricted leading-edge twisting via mechanical stoppers (type-B1: servo-bevel gear mechanism with adjustable mechanical stoppers). Utilizing a low-speed wind tunnel, the aerodynamic performances of these mechanisms are examined by extracting their lift and net thrust forces. The wind tunnel testing data showed that the flapping with restricted leading-edge twisting via mechanical stoppers (type-B1) showed better performance than the simple flapping (type-A1) by 32.9%, and also better performance than the flapping with continuous leading-edge twisting (type-B) by 64%. Next, MATLAB software was used to create the 3D wing surfaces from the instantaneous stereophotography Kwon3D trajectories to fully sketch the leading-edge twisting features. The 2D airfoil cut sections at the mean aerodynamic chord at different stroke moments depict the instantaneous angles of attack to justify the aforementioned wind tunnel testing data and it was verified using a theoretical trajectory model. This comprehensive study using the 3D-printed mechanisms is well suited for the quantitative evaluation of the lift contribution from leading-edge twisting.
Advancements in Nanofiber-Based Electrochemical Biosensors for Diagnostic Applications
Authors: Iftikhar Faiza Jan , Shah Afzal , Wali Qamar , Kokab Tayyaba
Published: March 2023

Biosensors are analytical tools that can be used as simple, real-time, and effective devices in clinical diagnosis, food analysis, and environmental monitoring. Nanoscale functional materials possess unique properties such as a large surface-to-volume ratio, making them useful for biomedical diagnostic purposes. Nanoengineering has resulted in the increased use of nanoscale functional materials in biosensors. Various types of nanostructures i.e., 0D, 1D, 2D, and 3D, have been intensively employed to enhance biosensor selectivity, limit of detection, sensitivity, and speed of response time to display results. In particular, carbon nanotubes and nanofibers have been extensively employed in electrochemical biosensors, which have become an interdisciplinary frontier between material science and viral disease detection. This review provides an overview of the current research activities in nanofiber-based electrochemical biosensors for diagnostic purposes. The clinical applications of these nanobiosensors are also highlighted, along with a discussion of the future directions for these materials in diagnostics. The aim of this review is to stimulate a broader interest in developing nanofiber-based electrochemical biosensors and improving their applications in disease diagnosis. In this review, we summarize some of the most recent advances achieved in point of care (PoC) electrochemical biosensor applications, focusing on new materials and modifiers enabling biorecognition that have led to improved sensitivity, specificity, stability, and response time.
Critical Approaches on the Changes Taking Place after 24/2014/EU in BIM Adoption Process
Authors: Fiamma Paolo , Biagi Silvia
Published: March 2023

In 2014, the European Union introduced the so-called BIM at the attention of the Member States with the European Directive 24/2014/EU to spread this method throughout Europe. Alongside the generally recurrent motivations (education, maturity in the construction sector, technical approaches) to understand the causes of the laborious and not yet wide diffusion of BIM in Europe, this work introduces an original way that still appears not explored well enough in the current research scenario: the analysis of the correctness of the technical terms used in the native text of the ED and the translated texts in the national languages. The goal is to demonstrate that incorrect technical terms can be misunderstood and interpreted, and they move away from the specific and original contents of Charles Eastman’s method. The misunderstanding of the real technical content of the legal obligation has conditioned the clarity, speed and effectiveness of the diffusion of BIM. It is necessary to include the acronym BIM in legal texts instead of the current generic expression “building information electronic modelling”. The strength of the article is to recover clarity with the original indication and definition of BIM and the limit is that, in general, all laws can be interpreted.
Optimization of Fresh and Mechanical Characteristics of Carbon Fiber-Reinforced Concrete Composites Using Response Surface Technique
Authors: Khan Muhammad Basit , Waqar Ahsan , Bheel Naraindas , Shafiq Nasir , Hamah Sor Nadhim , Radu Dorin , Benjeddou Omrane
Published: March 2023

As a top construction material worldwide, concrete has core weakness relating to low tensile resistance without reinforcement. It is the reason that a variety of innovative materials are being used on concrete to overcome its weaknesses and make it more reliable and sustainable. Further, the embodied carbon of concrete is high because of cement being used as the integral binder. Latest research trends indicate significant potential for carbon fiber as an innovative material for improving concrete mechanical strength. Although significant literature is available on the use of carbon fiber in concrete, a limited number of studies have focused on the utilization of carbon fiber for concrete mechanical strength improvement and the reduction of embodied carbon. Following the gap in research, this study aimed to investigate and optimize the use of carbon fiber for its mechanical characteristics and embodied carbon improvements. The use of carbon fiber in self-compacting concrete lowers sagging. The greatest quantity of carbon fiber is that it reduces the blockage ratio, forcing the concrete to solidify as clumps develop. With time, carbon fiber improves the durability of concrete. Self-compacting concrete with no carbon fiber has a poor tensile strength. Experiments were conducted by adding carbon fiber at 0.2%, 0.4%, 0.6%, 0.8%, and 1.0% by weight. Fresh concrete tests including slump test and L-box test, hardened concrete tests involving compressive strength and splitting tensile strength, and durability tests involving water absorption and acid attack test were conducted. Embodied carbon ratios were calculated for all of the mix ratios and decreasing impact, in the form of eco-strength efficiency, is observed with changes in the addition of carbon fiber in concrete. From the testing results, it is evident that 0.6% carbon fiber is the ideal proportion for increasing compressive strength and split tensile strength by 20.93% and 59%, respectively, over the control mix. Response Surface Methodology (RSM) is then applied to develop a model based on results of extensive experimentation. Optimization of the model is performed and final modelled equations are provided in terms of calculating the impact of addition of carbon fiber in concrete. Positive implications are devised for the development of concrete in the future involving carbon fiber.
Oncolytic Adenoviruses Armed with Co-Stimulatory Molecules for Cancer Treatment
Authors: Gryciuk Aleksander , Rogalska Marta , Baran Joanna , Kuryk Lukasz , Staniszewska Monika
Published: March 2023

In clinical trials, adenovirus vectors (AdVs) are commonly used platforms for human gene delivery therapy. High genome capacity and flexibility in gene organization make HAdVs suitable for cloning. Recent advancements in molecular techniques have influenced the development of genetically engineered adenovirus vectors showing therapeutic potential. Increased molecular understanding of the benefits and limitations of HAdVs in preclinical research and clinical studies is a crucial point in the engineering of refined oncolytic vectors. This review presents HAdV species (A–G) used in oncotherapy. We describe the adenovirus genome organizations and modifications, the possibilities oncolytic viruses offer, and their current limitations. Ongoing and ended clinical trials based on oncolytic adenoviruses are presented. This review provides a broad overview of the current knowledge of oncolytic therapy. HAdV-based strategies targeting tumors by employing variable immune modifiers or delivering immune stimulatory factors are of great promise in the field of immune oncologyy This approach can change the face of the fight against cancer, supplying the medical tools to defeat tumors more selectively and safely.
Thymoma and Thymic Carcinoma: Surgical Resection and Multidisciplinary Treatment
Authors: Zhang Yue , Lin Dong , Aramini Beatrice , Yang Fu , Chen Xi , Wang Xing , Wu Liang , Huang Wei , Fan Jiang
Published: March 2023

Thymoma and thymic carcinoma are the most common tumors of the anterior mediastinum and a relatively rare type of thoracic cancer. The prerequisite for surgery is clinical staging and operative evaluation, both of which are based on medical imaging. The best strategy for treating a thymic epithelial tumor is surgical resection of the organ and surrounding tissue. Thymectomy modalities vary, including open surgery and minimally invasive surgery, and surgeons have used various innovations to better meet the needs of the procedure; therefore, it is critical to select the appropriate procedure based on the patient’s characteristics. Evaluation of resectability is the first step of surgical resection for thymic tumors without distant metastasis. The decision regarding unresectability should be made carefully. During subsequent chemotherapy or chemoradiotherapy, reevaluation of whether an area is resectable or not remains essential. Despite numerous technological advances in the surgical treatment of thymic tumors, several contentious issues remain, including the selection of surgical approaches for difficult cases, the selection of video-assisted thoracoscopic approaches, the evaluation of resectability, minimally invasive surgery for locally advanced thymic tumors, lymphadenectomy in thymic tumors, neoadjuvant therapy for thymic tumors, debulking surgery, and salvage surgery. In solving these problems, the surgeon’s judgment, surgical experience, and surgical skills are especially important.
Experimental and Clinical Advances in Counteracting Progression of Solid Cancers
Authors: Nicolini Andrea
Published: March 2023

In recent decades, impressing technological developments have significantly advanced our understanding of cancer [...]
The Timing Sequence and Mechanism of Aging in Endocrine Organs
Authors: Yang He , Fang Bing , Wang Zixu , Chen Yaoxing , Dong Yulan
Published: March 2023

The world is increasingly aging, and there is an urgent need to find a safe and effective way to delay the aging of the body. It is well known that the endocrine glands are one of the most important organs in the context of aging. Failure of the endocrine glands lead to an abnormal hormonal environment, which in turn leads to many age-related diseases. The aging of endocrine glands is closely linked to oxidative stress, cellular autophagy, genetic damage, and hormone secretion. The first endocrine organ to undergo aging is the pineal gland, at around 6 years old. This is followed in order by the hypothalamus, pituitary gland, adrenal glands, gonads, pancreatic islets, and thyroid gland. This paper summarises the endocrine gland aging-related genes and pathways by bioinformatics analysis. In addition, it systematically summarises the changes in the structure and function of aging endocrine glands as well as the mechanisms of aging. This study will advance research in the field of aging and help in the intervention of age-related diseases.
Aid or Antagonize: Nuclear Long Noncoding RNAs Regulate Host Responses and Outcomes of Viral Infections
Authors: Kulkarni Viraj , Jayakumar Sahana , Mohan Mahesh , Kulkarni Smita
Published: March 2023

Long noncoding RNAs (lncRNAs) are transcripts measuring >200 bp in length and devoid of protein-coding potential. LncRNAs exceed the number of protein-coding mRNAs and regulate cellular, developmental, and immune pathways through diverse molecular mechanisms. In recent years, lncRNAs have emerged as epigenetic regulators with prominent roles in health and disease. Many lncRNAs, either host or virus-encoded, have been implicated in critical cellular defense processes, such as cytokine and antiviral gene expression, the regulation of cell signaling pathways, and the activation of transcription factors. In addition, cellular and viral lncRNAs regulate virus gene expression. Viral infections and associated immune responses alter the expression of host lncRNAs regulating immune responses, host metabolism, and viral replication. The influence of lncRNAs on the pathogenesis and outcomes of viral infections is being widely explored because virus-induced lncRNAs can serve as diagnostic and therapeutic targets. Future studies should focus on thoroughly characterizing lncRNA expressions in virus-infected primary cells, investigating their role in disease prognosis, and developing biologically relevant animal or organoid models to determine their suitability for specific therapeutic targeting. Many cellular and viral lncRNAs localize in the nucleus and epigenetically modulate viral transcription, latency, and host responses to infection. In this review, we provide an overview of the role of nuclear lncRNAs in the pathogenesis and outcomes of viral infections, such as the Influenza A virus, Sendai Virus, Respiratory Syncytial Virus, Hepatitis C virus, Human Immunodeficiency Virus, and Herpes Simplex Virus. We also address significant advances and barriers in characterizing lncRNA function and explore the potential of lncRNAs as therapeutic targets.
Retinal Development in a Precocial Bird Species, the Quail (Coturnix coturnix, Linnaeus 1758)
Authors: Álvarez-Hernán Guadalupe , de Mera-Rodríguez José Antonio , Calle-Guisado Violeta , Martín-Partido Gervasio , Rodríguez-León Joaquín , Francisco-Morcillo Javier
Published: March 2023

The quail (Coturnix coturnix, Linnaeus 1758), a notable model used in developmental biology, is a precocial bird species in which the processes of retinal cell differentiation and retinal histogenesis have been poorly studied. The purpose of the present research is to examine the retinogenesis in this bird species immunohistochemically and compare the results with those from previous studies in precocial and altricial birds. We found that the first PCNA-negative nuclei are detected at Stage (St) 21 in the vitreal region of the neuroblastic layer, coinciding topographically with the first αTubAc-/Tuj1-/Isl1-immunoreactive differentiating ganglion cells. At St28, the first Prox1-immunoreactive nuclei can be distinguished in the vitreal side of the neuroblastic layer (NbL), but also the first visinin-immunoreactive photoreceptors in the scleral surface. The inner plexiform layer (IPL) emerges at St32, and the outer plexiform layer (OPL) becomes visible at St35—the stage in which the first GS-immunoreactive Müller cells are distinguishable. Newly hatched animals show a well-developed stratified retina in which the PCNA-and pHisH3-immunoreactivies are absent. Therefore, retinal cell differentiation in the quail progresses in the stereotyped order conserved among vertebrates, in which ganglion cells initially appear and are followed by amacrine cells, horizontal cells, and photoreceptors. Müller glia are one of the last cell types to be born. Plexiform layers emerge following a vitreal-to-scleral gradient. Finally, our results suggest that there are no significant differences in the timing of different events involved in retinal maturation between the quail and the chicken, but the same events are delayed in an altricial bird species.
Passaging Primary Human Bronchial Epithelia Reduces CFTR-Mediated Fluid Transport and Alters mRNA Expression
Authors: Wu Tongde , Wrennall Joe A. , Dang Hong , Baines Deborah L. , Tarran Robert
Published: March 2023

Primary human bronchial epithelial cultures (HBECs) are used to study airway physiology, disease, and drug development. HBECs often replicate human airway physiology/pathophysiology. Indeed, in the search for cystic fibrosis (CF) transmembrane conductance regulator (CFTR) therapies, HBECs were seen as the “gold standard” in preclinical studies. However, HBECs are not without their limitations: they are non-immortalized and the requirement for human donors, especially those with rare genetic mutations, can make HBECs expensive and/or difficult to source. For these reasons, researchers may opt to expand HBECs by passaging. This practice is common, but to date, there has not been a robust analysis of the impact of expanding HBECs on their phenotype. Here, we used functional studies of airway surface liquid (ASL) homeostasis, epithelial barrier properties, and RNA-seq and Western blotting to investigate HBEC changes over two passage cycles. We found that passaging impaired CFTR-mediated ASL secretion and led to a reduction in the plasma membrane expression of the epithelial sodium channel (ENaC) and CFTR. Passaging also resulted in an increase in transepithelial resistance and a decrease in epithelial water permeability. We then looked for changes at the mRNA level and found that passaging significantly affected 323 genes, including genes involved in inflammation, cell growth, and extracellular matrix remodeling. Collectively, these data highlight the potential for HBEC expansion to impact research findings.
Customizable Fabrication Process for Flexible Carbon-Based Electrochemical Biosensors
Authors: Marculescu Catalin , Preda Petruta , Burinaru Tiberiu , Chiriac Eugen , Tincu Bianca , Matei Alina , Brincoveanu Oana , Pachiu Cristina , Avram Marioara
Published: March 2023

In recent research, 3D printing has become a powerful technique and has been applied in the last few years to carbon-based materials. A new generation of 3D-printed electrodes, more affordable and easier to obtain due to rapid prototyping techniques, has emerged. We propose a customizable fabrication process for flexible (and rigid) carbon-based biosensors, from biosensor design to printable conductive inks. The electrochemical biosensors were obtained on a 50 µm Kapton® (polyimide) substrate and transferred to a 500 µm PDMS substrate, using a 3D-extrusion-based printing method. The main features of our fabrication process consist of short-time customization implementation, fast small-to-medium batch production, ease of electrochemical spectroscopy measurements, and very good resolution for an extrusion-based printing method (100 µm). The sensors were designed for future integration into a smart wound dressing for wound monitoring and other biomedical applications. We increased their sensibility with electro-deposited gold nanoparticles. To assess the biosensors’ functionality, we performed surface functionalization with specific anti-N-protein antibodies for SARS-CoV 2 virus, with promising preliminary results.
Possible Role of Carbocysteine Syrup in the Deflation of Percutaneous Endoscopic Gastrostomy Balloons
Authors: Bassotti Gabrio , Castellani Danilo
Published: March 2023

Percutaneous endoscopic gastrostomy is the method of choice to allow enteral access in patients requiring long-term enteral nutrition. However, although generally safe, percutaneous tube positioning may be plagued by several complications. Among these, the deterioration and/or deflation of balloons serving as internal bolster is particularly worrisome in that it may lead to gastrostomy cannulas dislocation. Of interest, such balloon deflation may occur in up to 30% of cases for apparently unexplained causes. Here, we provide a hypothesis that could explain some of these causes.
Numerical and Experimental Investigations of CoNiCrAlY Particle Suspension Dynamics in Kerosene-Oxygen High Velocity Oxygen Fuel Spraying
Authors: Kannan Sundaravadivelu , Ba Te , Wan Stephen , Kang Chang Wei , Pan Jisheng , Zhang Zheng
Published: March 2023

Three-dimensional computational fluid dynamics (CFD) modelling is employed to simulate a typical high velocity oxygen fuel process (HVOF) under laboratory operating conditions. Two different modelling approaches, viz., the continuum and discrete models, are engaged to model the liquid fuel kerosene, and their influence on the resulting primary gas dynamics is investigated. Numerical results of the primary gas dynamics are validated against the available measurements and found to be in good agreement. It is observed that the fuel droplets less than 5 μm react completely inside the combustion chamber, whereas the larger droplets do not. With increasing fuel droplet size, the chemical reaction gets extended to the downstream of the combustion chamber, resulting in decreased flame temperature. Thus, it is inferred that a fuel droplet size of up to 5 μm yields better combustion characteristics. Discrete solid CoNiCrAlY particles are then injected into the high velocity primary gas stream, and their inflight dynamics are simulated. Results reveal that a maximum mean particle velocity of 700 m/s and a maximum particle temperature of 1350 K may be achieved under the given operating conditions. Particle deposit shape and size are determined both numerically and experimentally and found to be in good agreement. The influence of substrate stand-off distance on the particle deposit characteristics is investigated and reported in detail.
Release of Encapsulated Bioactive Compounds from Active Packaging/Coating Materials and Its Modeling: A Systematic Review
Authors: Siddiqui Shahida Anusha , Singh Shubhra , Bahmid Nur Alim , Mehany Taha , Shyu Douglas J. H. , Assadpour Elham , Malekjani Narjes , Castro-Muñoz Roberto , Jafari Seid Mahdi
Published: March 2023

The issue of achieving controlled or targeted release of bioactive compounds with specific functional properties is a complex task that requires addressing several factors, including the type of bioactive, the nature of the delivery system, and the environmental conditions during transportation and storage. This paper deals with extensive reporting for the identification of original articles using Scopus and Google Scholar based on active packaging as a novel packaging technology that controls the release of antimicrobial agents encapsulated into carriers in the food packaging systems. For evidence-based search, the studies were extracted from 2015 to 2020 and screened using the 2020 Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Following the review and screening of publications, 32 peer-reviewed articles were subjected to systematic analysis. The preliminary search indicated that the encapsulation of bioactives enhances their bioavailability and stability. From a theoretical viewpoint, mathematical models play an important role in understanding and predicting the release behavior of bioactives during transportation and storage, thus facilitating the development of new packaging material by a systematic approach. However, only a few studies could formulate parameters for mathematical models in order to achieve the specific release mechanism regulated for the quality and safety of foods. Therefore, this paper will cover all encapsulation approaches, active packaging, and mathematical modeling in the food industry into structural form and analyze the challenges faced by the complex nature of active packaging in real food systems.
Chemical Adsorption of HF, HCl, and H2O onto YF3 and Isostructural HoF3 Surfaces by First Principles
Authors: Anders Jennifer , Wiedenhaupt Henrik , Paulus Beate
Published: March 2023

The two elements, yttrium and holmium, form a geochemical twin pair as their cations possess equivalent ratios of charge to radius. However, despite their equal electrostatics, a subtle difference in their fluoride or chloride affinity is known within solutions. In this work, we investigated whether this affinity gap is also present within the solid phase and how it depends on the surface configuration. We modeled adsorptions onto β-YF3 (waimirite) and isostructural β-HoF3 by periodic density functional theory. To draw conclusions on the affinity toward fluoride and chloride vs. water, adsorbates of HF, HCl, or H2O onto any of the four highly abundant surfaces of (010), (100), (011), and (101) were studied. Among others, the conformational landscape was explored by 200 ps of ab initio molecular dynamics. For stoichiometric surfaces of both MF3, we indeed found stronger adsorptions for HF than HCl. All (hkl)·H2O showed slightly stronger adsorption energies for HoF3, while for HF and HCl, the metal preferences varied by the surface. While (100) showed the strongest preference for HoF3, (101) preferred YF3 by the same magnitude.
What Can Trigger Spontaneous Regression of Breast Cancer?
Authors: D’Alessandris Nicoletta , Santoro Angela , Arciuolo Damiano , Angelico Giuseppe , Valente Michele , Scaglione Giulia , Sfregola Stefania , Carlino Angela , Navarra Elena , Mulè Antonino , Zannoni Gian Franco
Published: March 2023

Background: Spontaneous regression of tumors is a rare phenomenon in which cancer volume is reduced or, alternatively, a tumor completely disappears in the absence of any pharmacological treatment. This phenomenon has previously been described in several tumors, such as neuroblastomas, testicular malignancies, renal cell carcinomas, melanomas, and lymphomas. Spontaneous remission has also been documented in breast cancer; however, it represents an extremely rare and poorly understood phenomenon, with only a few reported cases in the literature. Methods: We herein report two cases of breast cancer that showed spontaneous tumor regression in the surgical specimen after a pathologically confirmed diagnosis of invasive breast cancer in core needle biopsy samples. Results: Macroscopically, both the surgical samples revealed a whitish, fibrous area with a rubbery consistency. On histological examination, diffuse fibrous tissue, hemosiderin deposition, and chronic inflammation were observed. The first case showed the complete disappearance of the tumor, whereas the second case showed just a small (3 mm), residual nest of neoplastic cells. Conclusions: Although spontaneous regression of breast cancer is a rare event, it is important to know that it might happen. It is also of great importance to try to better explain, over time, its underlying mechanism. This knowledge could help us to further develop cancer prevention methods and predict the clinical course of these kinds of neoplasms.
Relationship of Vessel Density to Vessel Length Density in Patients with Treated Fabry Disease
Authors: Wiest Maximilian Robert Justus , Toro Mario Damiano , Nowak Albina , Bajka Anahita , Fasler Katrin , Al-Sheikh Mayss , Hamann Timothy , Zweifel Sandrine Anne
Published: March 2023

Background: Fabry disease (FD) is a potentially lethal lysosomal disorder with systemic vascular changes. Previous studies demonstrated retinal vascular involvement using optical coherence tomography angiography (OCTA) in affected patients; Aim: To analyze and quantify the retinal vasculature measuring vessel density (VD), vessel length density (VLD), and the ratio of VD to VLD (VD/VLD) in superficial capillary plexuses (SCP) and deep capillary plexuses (DCP) using OCTA in patients with FD and to show whether they differ from healthy controls (HC); Patients and methods: Single-center, retrospective, consecutive cohort study of patients with genetically proven FD. Patients underwent an ophthalmological examination including OCTA. VD, VLD, foveal avascular zone (FAZ), and the VD/VLD were compared to an HC group using a linear mixed model; Results: A statistically significant difference in the VLD and VD/VLD of DCP was observed between the two groups (p < 0.001). Using ROC curves with AUC and Youden’s Index, a cut-off value for differentiating both groups using VD/VLD in DCP FD with high specificity and high sensitivity was established; Conclusions: FD and HC groups seem to be separable using the VD/VLD ratio in DCP. This new biomarker might differentiate changes in the retinal microvasculature that are not detectable by VD or VLD alone.
Conditional Entropic Approach to Nonequilibrium Complex Systems with Weak Fluctuation Correlation
Authors: Itto Yuichi
Published: March 2023

A conditional entropic approach is discussed for nonequilibrium complex systems with a weak correlation between spatiotemporally fluctuating quantities on a large time scale. The weak correlation is found to constitute the fluctuation distribution that maximizes the entropy associated with the conditional fluctuations. The approach is illustrated in diffusion phenomenon of proteins inside bacteria. A further possible illustration is also presented for membraneless organelles in embryos and beads in cell extracts, which share common natures of fluctuations in their diffusion.
Macroeconomic Factors of Consumer Loan Credit Risk in Central and Eastern European Countries
Authors: Kanapickienė Rasa , Keliuotytė-Staniulėnienė Greta , Vasiliauskaitė Deimantė , Špicas Renatas , Neifaltas Airidas , Valukonis Mantas
Published: March 2023

In the scientific literature, there is a lack of a systematic approach to credit risk factors. In addition, insufficient attention is still paid to analysing the macroeconomic factors of consumer loan credit risk. Thus, this research aims to evaluate the macroeconomic factors of consumer loan credit risk in Central and Eastern European countries’ banking systems. The findings of the study can be formulated as follows. After analysing scientific literature on credit risk factors, an improved and detailed (at five different levels) classification of factors influencing banking credit risk is proposed. This classification can be beneficial for more enhanced analysis of the factors influencing banking credit risk for the whole loan portfolio as well as for different types of loans, e.g., consumer loans. For quantitative evaluation of the impact of macroeconomic factors on consumer loan credit risk, the methods of panel data analysis and bivariate and multiple regressions are employed. Eleven CEE countries in the period from 2008 to 2020 are analysed. The results revealed that the aggregate of general macroeconomic condition factors is negatively related to consumer loan NPLs. Moreover, the economic growth, stock market, foreign exchange market, and institutional environment factors proved to be risk-decreasing, while credit market and bond market factors had a risk-increasing impact. The results of this research might help financial institutions manage credit risk more efficiently and also might be relevant to governments and central banks when selecting and applying fiscal and monetary policy measures. This study also makes policy recommendations.
Review on Electrode Degradation at Fast Charging of Li-Ion and Li Metal Batteries from a Kinetic Perspective
Authors: Miao Jinghui
Published: March 2023

With the surge of electric vehicles, fast charging has become one of the major challenges for the development of Li-ion and Li metal batteries. The degradation of battery electrodes at fast charging has been identified as among the gating factors. While there have been extensive studies on anode and cathode degradation modes, not sufficient efforts have been made to dive deep into the kinetics of battery charging and its influence on electrode degradation, especially during fast charging. This review presents a comprehensive yet concentrated perspective into such issues. By tracing back to the kinetic origins of battery charging, it is revealed that the intrinsic properties of electrode active materials and the microstructures of electrode are of great importance in determining electrode kinetics. Most of the electrode degradation modes are closely related to the high overpotentials and the spatial inhomogeneity in Li concentration and pertinent characteristics, which are results of the sluggish electrode kinetics during fast charging. Approaches to mitigate electrode degradation are summarized from the aspect of improving electrode kinetics and circumventing detrimental side reactions.
Load-Following Operation of Small Modular Reactors under Unit Commitment Planning with Various Photovoltaic System Conditions
Authors: Ahn Seong-Hyeon , Hyun Jin-Hee , Choi Jin-Ho , Lee Seong-Geun , Kim Gyu-Gwang , Bhang Byeong-Gwan , Cha Hae-Lim , Lim Byeong-Yong , Choi Hoon-Joo , Ahn Hyung-Keun
Published: March 2023

Globally, renewable energies are indispensable resources on account of RE100 and the Paris Agreement. The most developed renewable energies are photovoltaics (PV) and wind energy, and they are continuously expanding. This study aims to optimize and analyze the nuclear power plant (NPP) load-following operation in various PV conditions in a metropolitan region. With theoretically estimated power demand and PV power, a mixed-integer problem (MIP) with ramping cycle constraint (RCC) was constructed for a safe load-following operation and simulated through duck curves under various NPP load-following regions (the extreme, normal, and safe regions). The simulation showed two major results for NPP load-following. Technically, RCC successfully controlled the NPP ramp cycle and was assured to be an optimization tool for NPP operation. Numerically, NPP load-following alleviated PV intermittency to almost 50%, 30%, and 15% depending on the load-following region. However, these effects were restricted when the PV capacity rate was high, especially when it exceeded 60%. Thus, PV system capacity is recommended to be 63% of the maximum power demand in the metropolitan region with NPP load-following, and larger PV systems need more flexibility.
Cumulative Interactions between the Global Blockage and Wake Effects as Observed by an Engineering Model and Large-Eddy Simulations
Authors: Cañadillas Beatriz , Foreman Richard , Steinfeld Gerald , Robinson Nick
Published: March 2023

By taking into account the turbine type, terrain, wind climate and layout, the effects of wind turbine wakes and other losses, engineering models enable the rapid estimation of energy yields for prospective and existing wind farms. We extend the capability of engineering models, such as the existing deep-array wake model, to account for additional losses that may arise due to the presence of clusters of wind farms, such as the global blockage effect and large-scale wake effects, which become more significant with increasing thermal stratification. The extended strategies include an enhanced wind-farm-roughness approach which assumes an infinite wind farm, and recent developments account for the upstream flow blockage. To test the plausibility of such models in capturing the additional blockage and wake losses in real wind farm clusters, the extended strategies are compared with large-eddy simulations of the flow through a cluster of three wind farms located in the German sector of the North Sea, as well as real measurements of wind power within these wind farms. Large-eddy simulations and wind farm measurements together suggest that the extensions of the Openwind model help capture the different flow features arising from flow blockage and cluster effects, but further model refinement is needed to account for higher-order effects, such as the effect of the boundary-layer height, which is not currently included in standard engineering models.
Determination of Effective Flow and Force Areas for Reed Type Compressor Valve Systems: Part 1—Model Derivation Using CFD Analysis Results
Authors: Park Jeong Deok , Lee Seong Jin , Ahn Jun-young , Kim Jinkook , Kim Jong Bong
Published: March 2023

The dynamic behavior of reed valves during suction and discharge is very important in predicting compressor performance and valve fatigue fracture. For an accurate dynamic analysis of reed valves, mass flow rate and effective force area should be accurately modeled. In this study, mass flow rate and effective force area models were developed based on CFD analysis results using the well-known commercial software ANSYS Fluent. CFD analyses were carried out for various values of port radius, valve radius, valve lift, and pressure difference. The mass flow rate and pressure force on valve were obtained from the analysis. Then, effective flow and force area models were proposed and the model coefficients were determined using the CFD results. The average prediction error of the effective flow area and the effective force area were 1.90% and 2.9%, respectively. It was shown that the effective flow area is dependent only on the port radii and valve lift; it is not dependent on the valve radii. The proposed effective force area model can accurately describe the decrease and increase in pressure force with valve lift.
Inductive Wireless Power Transfer Systems for Low-Voltage and High-Current Electric Mobility Applications: Review and Design Example
Authors: Tran Manh Tuan , Thekkan Sarath , Polat Hakan , Tran Dai-Duong , El Baghdadi Mohamed , Hegazy Omar
Published: March 2023

Along with the technology boom regarding electric vehicles such as lithium-ion batteries, electric motors, and plug-in charging systems, inductive power transfer (IPT) systems have gained more attention from academia and industry in recent years. This article presents a review of the state-of-the-art development of IPT systems, with a focus on low-voltage and high-current electric mobility applications. The fundamental theory, compensation topologies, magnetic coupling structures, power electronic architectures, and control methods are discussed and further considered in terms of several aspects, including efficiency, coil misalignments, and output regulation capability. A 3D finite element software (Ansys Maxwell) is used to validate the magnetic coupler performance. In addition, a 2.5 kW 400/48 V IPT system is proposed to address the challenges of low-voltage and high-current wireless charging systems. In this design, an asymmetrical double-sided LCC compensation topology and a passive current balancing method are proposed to provide excellent current sharing capability in the dual-receiver structures under both resonant component mismatch and misalignment conditions. Finally, the performance of the proposed method is verified by MATLAB/PSIM simulation results.
Energy Transition and the Economy: A Review Article
Authors: Genc Talat S. , Kosempel Stephen
Published: March 2023

The global energy sector is in a period of transition, during which time it is expected that renewable and low-carbon energy sources, such as wind and solar, will replace traditional fossil fuels, including oil, gas, and coal. The energy transition is happening not only to limit the environmental impact of fossil fuel production and consumption but also to ensure energy security, reliability, access, affordability, and sustainability. The importance of the energy transition has been amplified by recent events, notably the Russian-Ukraine conflict. Economic, financial, and trade sanctions against Russia, and in particular its oil and gas industry, have forced countries to find new suppliers in the short term, but also to investigate new and more sustainable sources to guarantee long-term energy security. Given the importance of energy, it is perhaps not unexpected that there is a considerable body of recent academic literature, particularly over the last 4–5 years, studying what industries, consumers, governments, and markets can do to help bring about a faster energy transition. In this paper, we provide a review of the literature that pertains to the economic aspects of the energy transition. While our initial search of the literature is targeted at uncovering all relevant articles on the subject, we focus most of our discussion on the most influential articles in prominent journals and articles published in this journal—Energies. This review is intended to help identify active topics and potential research gaps and provide future direction, so we hope it will prove useful to the readers and authors interested in this topic.
A Design of a 2 DoF Planar Parallel Manipulator with an Electro-Pneumatic Servo-Drive—Part 2
Authors: Takosoglu Jakub , Janus-Galkiewicz Urszula , Galkiewicz Jaroslaw
Published: March 2023

This paper is the second part of the study of a planar manipulator and this section presents the construction of a prototype manipulator. A fuzzy control system for the manipulator is described in detail. An experimental study was carried out on the positioning of the end effector of the manipulator and a program written in the Delphi 6 environment was proposed to calculate the position. Prototype tests were performed for transpose and follow-up control. Based on the experimental results, a control quality analysis was carried out.
The Role of Carbonate Formation during CO2 Hydrogenation over MgO-Supported Catalysts: A Review on Methane and Methanol Synthesis
Authors: Suksumrit Kamonrat , Kleiber Sascha , Lux Susanne
Published: March 2023

Methane and methanol are promising products for CO2 hydrogenation for carbon capture and utilization concepts. In the search for effective, robust, easy-to-manufacture and stable catalysts, supported metal-based catalysts have proven advantageous. Whereas nickel for methane synthesis and copper for methanol synthesis stand out as efficient and cost-effective catalytically active metals, the best choice of support material is still a matter of ongoing debate. This review discusses the potential of the alkaline earth metal oxide MgO as support material for CO2 hydrogenation catalysts. Due to its basicity, it gives access to bifunctional catalysts as it shows pronounced CO2 adsorption capacity. Whereas carbonate formation seems to be beneficial in CO2 methanation, it may even have an adverse effect in methanol synthesis from CO2.
Molecular Reconstruction Method Based on NIR Spectroscopy for Reformates
Authors: Cheng Mingyuan , Zhang Linzhou
Published: March 2023

With the increasing attention to environmental protection and strict national standards, the production of high-quality clean gasoline is more and more required in modern refineries. At present, the molecular-level online modeling of the gasoline blending process is rarely reported due to the lack of a proper characterization method. In this study, we have developed a molecular reconstruction method based on near-infrared (NIR) spectroscopy. We established a library that comprises an NIR spectrum and molecular composition of known reformates. We developed the sample selection algorithm that finds the sample with an NIR spectrum close to the target sample. The method-solving algorithm based on multiple linear regression was used to obtain the molecular composition of gasoline quickly. The method combines online measurement methods and molecular management technology to achieve online composition reconstruction. Seventy-five groups of reformates were collected to verify the feasibility of the method, and the results showed that the method predicted well.