bluuebunny/crossref_metadata_2025 huggingface dataset:
Public Attitudes and Sentiments toward Common Prosperity in China: A Text Mining Analysis Based on Social Media
Authors: Li Yang , Duan Tianyu , Zhu Lijing
Published: May 2024

Since 2021, China’s promotion of common prosperity has captured global attention and sparked considerable debate. Yet, scholarly examination of the Chinese public’s attitudes toward this policy, which is crucial for guiding China’s strategic directions, remains limited. To address this gap, this paper collects 256,233 Sina Weibo posts from 2021 to 2023 and utilizes text mining methods such as temporal and trend analysis, keyword analysis, topic analysis, and sentiment analysis to investigate the attitudes and emotions of the Chinese people towards common prosperity. The posts holding negative sentiments are also analyzed, so as to uncover the underlying reasons for the dissatisfaction among Chinese citizens regarding common prosperity. Our analysis reveals that China’s strategy for promoting common prosperity is primarily focused on economic development rather than wealth redistribution. Emphasis is placed on enhancing education, achieving regional balance, implementing market-oriented reforms, and improving livelihoods. Notably, there is increasing public dissatisfaction, particularly with issues such as irregularities in financial and real estate markets, growing wealth inequality, exploitation by capital, generation of illicit income, and regional development imbalances. These challenges necessitate urgent and effective policy interventions.
Advances in Cybersecurity: Challenges and Solutions
Authors: Trim Peter R. J. , Lee Yang-Im
Published: May 2024

Cyberattacks have increased in intensity and sophistication in recent years, resulting in defensive actions to safeguard company assets and vulnerable people [...]
Alleviating Effect of a Flower Extract of Styphnolobium japonicum L. on Symptoms of Experimentally Induced Osteoarthritis in Rats
Authors: Lee Woo Jin , Kim Kyung-Mi , Lee Somin , Park Seong Yeon , Kim Ha-Jin , Imm Jee-Young , Jung Jae-Chul
Published: May 2024

In the present study, we prepared an ethanol extract from the flowers of Styphnolobium japonicum L. (SJFE) and found that it contains rutin as a major constituent as well as quercetin kaempferol and isorhamnetin as minor components. In lipopolysaccharide-stimulated RAW 264.7 macrophages, we observed that SJFE significantly inhibited the production of nitric oxide and the expression of major inflammatory biomarkers such as inducible NO synthase, cyclooxygenase-2, interleukin (IL)-6, and IL-1β significantly. Based on these in vitro results, we investigated the anti-inflammatory properties of SJFE on osteoarthritis (OA) of the left hind knee joints induced by monosodium iodoacetate in rats. SJFE was orally administered to the rats with arthritis for 4 weeks, and the following results were obtained. The rats treated with SJFE exhibited a 24% improvement in the weight-bearing index of their affected legs, as well as reductions of 31.5% and 23.2% in serum levels of cartilage oligomeric matrix protein and C-terminal telopeptide 2, respectively. Additionally, Mankin’s score, an indicator used to assess the severity of joint cartilage damage, decreased by 2.75 points compared to the control with no treatment. These findings suggest that SJFE possesses anti-inflammatory properties and can alleviate symptoms of OA, indicating its potential to offer relief to individuals suffering from arthritis.
Balancing Data Acquisition Benefits and Ordering Costs for Predictive Supplier Selection and Order Allocation
Authors: Regattieri Alberto , Gabellini Matteo , Calabrese Francesca , Civolani Lorenzo , Galizia Francesco Gabriele
Published: May 2024

The strategic selection of suppliers and the allocation of orders across multiple periods have long been recognized as critical aspects influencing company expenditure and resilience. Leveraging the enhanced predictive capabilities afforded by machine learning models, direct lookahead models—linear programming models that optimize future decisions based on forecasts generated by external predictive modules—have emerged as viable alternatives to traditional deterministic and stochastic programming methodologies to solve related problems. However, despite these advancements, approaches implementing direct lookahead models typically lack mechanisms for updating forecasts over time. Yet, in practice, suppliers often exhibit dynamic behaviours, and failing to update forecasts can lead to suboptimal decision-making. This study introduces a novel approach based on parametrized direct lookahead models to address this gap. The approach explicitly addresses the hidden trade-offs associated with incorporating forecast updates. Recognizing that forecasts can only be updated by acquiring new data and that the primary means of acquiring supplier-related data is through order allocation, this study investigates the trade-offs between data acquisition benefits and order allocation costs. An experimental design utilizing real-world automotive sector data is employed to assess the potential of the proposed approach against various benchmarks. These benchmarks include decision scenarios representing perfect foresight, no data acquisition benefits, and consistently positive benefits. Empirical findings demonstrate that the proposed approach achieves performance levels comparable to those of decision-makers with perfect foresight while consistently outperforming benchmarks not balancing order allocation costs and data acquisition benefits.
Effect of Protein (Bovine Serum Albumin) Content on the Frictional Behaviour of Soft Contact Lenses Using a Dynamic Oscillating Tribometer
Authors: Vilhena Luís , Ramalho Amílcar
Published: May 2024

Proteins can adsorb on the surface of materials, such as soft contact lenses (SCLs), and can affect the hydrophobicity, roughness, and surface properties of the contact lenses (CLs), which, in turn, can influence the friction between the lenses and the ocular surface. Excessive friction between contact lenses and the ocular surface can lead to discomfort for the wearer and may cause irritation or inflammation of the cornea, better known as corneal ulcers (keratitis). Bovine Serum Albumin (BSA) is often used as a standard protein in biocompatibility testing of materials, including contact lenses. One standard commercial contact lens was tested under lubricated conditions to access the coefficient of friction (CoF). The contact was lubricated with a tear-like fluid (TLF) solution containing six different concentrations of BSA. In all cases, good linearity of the results of the friction force was verified, suggesting that the first friction law can be applied to determine the value of the coefficient of friction. It was found that friction increases with the increase in protein concentration.
The Activation Energy Temperature Dependence for Viscous Flow of Chalcogenides
Authors: Mashanov Alexey A. , Ojovan Michael I. , Darmaev Migmar V. , Razumovskaya Irina V.
Published: May 2024

For some chalcogenide glasses, the temperature dependence of the activation energy E(T) of viscous flow in the glass transition region was calculated using the Williams–Landel–Ferry (WLF) equation. A method for determining the activation energy of viscous flow as a function of temperature is proposed using the Taylor expansion of the function E(T) using the example of chalcogenide glasses As-Se, Ge-Se, Sb-Ge-Se, P-Se, and AsSe-TlSe. The calculation results showed that the temperature dependence of the activation energy for the Ge-Se, As-Se, P-Se, AsSe-TlSe, and AsSe systems is satisfactorily described by a polynomial of the second degree, and for Sb-Ge-Se glass by a polynomial of the third degree. The purpose of this work is to compare the values of the coefficients obtained from the Taylor series expansion of E(T) with the characteristics of the E(T) versus (T − Tg) curves obtained directly from the experimental temperature dependence of viscosity. The nature of the dependence E(T) is briefly discussed.
High-Speed Surface Property Recognition with a 140 GHz Frequency
Authors: Liu Jiacheng , Li Da , Liu Guohao , Qiao Yige , Wei Menghan , Zhang Chengyu , Ma Jianjun
Published: May 2024

In the field of integrated sensing and communication, there is a growing need for advanced environmental perception. The terahertz (THz) frequency band, significant for ultra-high-speed data connections, shows promise in environmental sensing, particularly in detecting surface textures crucial for autonomous systems’ decision-making. However, traditional numerical methods for parameter estimation in these environments struggle with accuracy, speed, and stability, especially in high-speed scenarios like vehicle-to-everything communications. This study introduces a deep learning approach for identifying surface roughness using a 140-GHz setup tailored for such conditions. A high-speed data acquisition system was developed to mimic real-world scenarios, and a diverse set of rough surface samples was prepared for realistic high-speed datasets to train the models. The model was trained and validated in three challenging scenarios: random occlusions, sparse data, and narrow-angle observations. The results demonstrate the method’s effectiveness in high-speed conditions, suggesting terahertz frequencies’ potential in future sensing and communication applications.
Interlayer Shear Sliding Behaviors during the Fracture Process of Thick Sandstone Roof and Its Mechanism Leading to Coal Mine Tremors
Authors: Gao Xuepeng , Pan Yishan , Zhao Tongbin , Wang Wei , Xiao Yonghui , Song Yimin , Dai Lianpeng
Published: May 2024

To explore the causes of mine tremors in coal mines with sandstone roofs, a three-point bending loading experiment was designed for composite sandstone layers, and the fracture and interlayer shear slip characteristics of the composite sandstone layers were studied using optical measurement and acoustic emission techniques. The results show that the bending of the rock layers led to interlayer sliding deformation, while the fracturing greatly promoted interlayer sliding. The maximum interlayer slip accelerations during bending deformation and fracturing were 0.6 mm/s2 and 3.8 mm/s2, respectively. During the fracturing of the rock layers, the proportion of acoustic emission shear fracture events increased with the continuous occurrence of long-lasting and high-amplitude acoustic emission events. The mechanism of mine tremors in thick sandstone roofs is as follows: the increase in the area of the goaf causes rock bending deformation and fracturing, accompanied by interlayer shear slip, fracturing of the sandstone layer, and friction dislocation at the cementation surface of the adjacent sandstone layers, which jointly cause vibration of the roof.
Assessment of Deadly Heat Stress and Extreme Cold Events in the Upper Midwestern United States
Authors: Khan Manas , Bhattarai Rabin , Chen Liang
Published: May 2024

Understanding and addressing the implications of extreme temperature-related events are critical under climate change, as they directly impact public health and strain energy infrastructure. This study delved into the critical assessment of deadly heat stress and extreme cold events in the Upper Midwestern United States (UMUS), from 1979 to 2021, recognizing the substantial and disparate impact these phenomena have on socially vulnerable communities. In the current study, the modified Mann–Kendall method was applied to understand the temporal trend of extreme heat stress, as well as extreme cold events, from 1979 to 2021 in the UMUS. The results showed that the average annual frequency of daytime extreme heat stress events was comparatively lower in the northern parts of the UMUS compared to the southern parts from 1979 to 2021. Furthermore, a significant increasing trend in daytime extreme heat stress was found in parts of Michigan, Wisconsin (around the lake region), Ohio, and lower parts of Indiana and Kentucky from 1979 to 2021. In contrast, a decreasing trend was noticed in western parts of the UMUS (parts of Minnesota, Iowa, and Missouri). A significant decreasing trend in extreme cold events was found throughout the UMUS from 1979 to 2021. However, an increasing trend was also noticed in Iowa and northern parts of Minnesota, Michigan, and Wisconsin. The results provide important insights for better understanding the unique risks posed by extreme temperature-related events, especially toward socially vulnerable communities in the UMUS, which is crucial for developing targeted interventions and fostering resilience in the face of escalating climate-related threats.
Regular, Beating and Dilogarithmic Breathers in Biased Photorefractive Crystals
Authors: Betancur-Silvera Carlos Alberto , Espinosa-Cerón Aurea , Malomed Boris A. , Fujioka Jorge
Published: May 2024

The propagation of light beams in photovoltaic pyroelectric photorefractive crystals is modelled by a specific generalization of the nonlinear Schrödinger equation (GNLSE). We use a variational approximation (VA) to predict the propagation of solitary-wave inputs in the crystals, finding that the VA equations involve a dilogarithm special function. The VA predicts that solitons and breathers exist, and the Vakhitov–Kolokolov criterion predicts that the solitons are stable solutions. Direct simulations of the underlying GNLSE corroborates the existence of such stable modes. The numerical solutions produce both regular breathers and ones featuring beats (long-period modulations of fast oscillations). In the latter case, the Fourier transform of amplitude oscillations reveals a nearly discrete spectrum characterizing the beats dynamics. Numerical solutions of another type demonstrate the spontaneous splitting of the input pulse in two or several secondary ones.
Carrabiitol®, a Novel Oligosaccharide Polyol Composition, Mitigates the Impact of Flooding, Drought, Salinity, and High Temperature in Tomato
Authors: Patel Femida Yunus , Upreti Kaushal Kishore , Laxman Ramanna Hunashikatti , Shah Neil Jaykumar
Published: May 2024

Abiotic stress results in various physiological and biochemical changes in plants. Osmolytes play a pivotal role in improving the tolerance to abiotic stress in plants. This study evaluated the effectiveness of a commercial formulation, Carrabiitol®, an oligosaccharide polyol composition, in alleviating adverse impacts of abiotic stress in tomato (Solanum lycopersicum L. var. Arka Rakshak) plants. Plants were raised from seed and treated with 1 mL/L, 2 mL/L, and 3 mL/L of Carrabiitol®. The foliage of developing plants was treated at the 2–3 leaf stage (T2, T3, and T4) and at pre-flowering stage (T5, T6, and T7). Growth conditions were compared with those of plants developed from untreated seed (T1). Developing tomato plants were then exposed to flooding, salinity (50 mM NaCl), high temperature (41.1 °C), or drought at the flowering stage. Plants were evaluated for their dry weight, leaf water potential, stomatal conductance, transpiration rate, antioxidant potential, chlorophyll, carotenoid, glucose, sucrose, malondialdehyde, and proline contents. Pre-treated seed, which received a booster treatment at the 2–3 leaf stage (T4 = seed treatment and booster at the 2–3 leaf stage with 3 mL/L Carrabiitol®) and pre-flowering stages (T5, T6, and T7 = seed treatment and booster doses at the pre-flowering stage with 1, 2, and 3 mL/L Carrabiitol®, respectively), was effective in mitigating negative impacts on various growth parameters of stressed tomato plants (p < 0.05). Carrabiitol® may be an effective, sustainable, and bio-rational organic osmolyte formulation for reducing the effects of abiotic stress on plant growth and productivity.
PPARγ Antagonists Exhibit Antitumor Effects by Regulating Ferroptosis and Disulfidptosis
Authors: Zhang Shiyu , Wang Ying , Gu Junjie , Yang Yang , Liang Jing , Wang Yimei , Ji Ning , Liu Ming , Zhang Yingxin , Sun Silu , Chen Qianming , Li Jing
Published: May 2024

Oral squamous cell carcinoma (OSCC) stands as a prevalent subtype of head and neck squamous cell carcinoma, leading to disease recurrence and low survival rates. PPARγ, a ligand-dependent nuclear transcription factor, holds significance in tumor development. However, the role of PPARγ in the development of OSCC has not been fully elucidated. Through transcriptome sequencing analysis, we discovered a notable enrichment of ferroptosis-related molecules upon treatment with PPARγ antagonist. We subsequently confirmed the occurrence of ferroptosis through transmission electron microscopy, iron detection, etc. Notably, ferroptosis inhibitors could not completely rescue the cell death caused by PPARγ inhibitors, and the rescue effect was the greatest when disulfidptosis and ferroptosis inhibitors coexisted. We confirmed that the disulfidptosis phenotype indeed existed. Mechanistically, through qPCR and Western blotting, we observed that the inhibition of PPARγ resulted in the upregulation of heme oxygenase 1 (HMOX1), thereby promoting ferroptosis, while solute carrier family 7 member 11 (SLC7A11) was also upregulated to promote disulfidptosis in OSCC. Finally, a flow cytometry analysis of flight and multiplex immunohistochemical staining was used to characterize the immune status of PPARγ antagonist-treated OSCC tissues in a mouse tongue orthotopic transplantation tumor model, and the results showed that the inhibition of PPARγ led to ferroptosis and disulfidptosis, promoted the aggregation of cDCs and CD8+ T cells, and inhibited the progression of OSCC. Overall, our findings reveal that PPARγ plays a key role in regulating cell death in OSCC and that targeting PPARγ may be a potential therapeutic approach for OSCC.
Palmitic Acid Exerts Anti-Tumorigenic Activities by Modulating Cellular Stress and Lipid Droplet Formation in Endometrial Cancer
Authors: Zhao Ziyi , Wang Jiandong , Kong Weimin , Newton Meredith A. , Burkett Wesley C. , Sun Wenchuan , Buckingham Lindsey , O’Donnell Jillian , Suo Hongyan , Deng Boer , Shen Xiaochang , Zhang Xin , Hao Tianran , Zhou Chunxiao , Bae-Jump Victoria L.
Published: May 2024

Epidemiological and clinical evidence have extensively documented the role of obesity in the development of endometrial cancer. However, the effect of fatty acids on cell growth in endometrial cancer has not been widely studied. Here, we reported that palmitic acid significantly inhibited cell proliferation of endometrial cancer cells and primary cultures of endometrial cancer and reduced tumor growth in a transgenic mouse model of endometrial cancer, in parallel with increased cellular stress and apoptosis and decreased cellular adhesion and invasion. Inhibition of cellular stress by N-acetyl-L-cysteine effectively reversed the effects of palmitic acid on cell proliferation, apoptosis, and invasive capacity in endometrial cancer cells. Palmitic acid increased the intracellular formation of lipid droplets in a time- and dose-dependent manner. Depletion of lipid droplets by blocking DGAT1 and DGAT2 effectively increased the ability of palmitic acid to inhibit cell proliferation and induce cleaved caspase 3 activity. Collectively, this study provides new insight into the effect of palmitic acid on cell proliferation and invasion and the formation of lipid droplets that may have potential clinical relevance in the treatment of obesity-driven endometrial cancer.
Hydrogels with Ultrasound-Treated Hyaluronic Acid Regulate CD44-Mediated Angiogenic Potential of Human Vascular Endothelial Cells In Vitro
Authors: Elvitigala Kelum Chamara Manoj Lakmal , Mubarok Wildan , Sakai Shinji
Published: May 2024

The development of hydrogels that allow vascular endothelial cells to form capillary-like networks is critical for advancing tissue engineering and drug discovery. In this study, we developed hydrogels composed of phenolated hyaluronic acid (HA-Ph) with an average molecular weight of 490–159 kDa via sonication in an aqueous solution. These hydrogels were synthesized by the horseradish peroxidase-catalyzed crosslinking of phenol moieties in the presence of hydrogen peroxide and phenolated gelatin. The sonication-degraded HA-Ph (198 kDa) significantly enhanced the migration ability of human umbilical vein endothelial cells (HUVECs) on cell culture plates when added to the medium compared to the original HA-Ph (490 kDa) and less-degraded HA-Ph (312–399 kDa). In addition, HUVECs cultured on these hydrogels formed networks that did not occur on hydrogels made from the original HA-Ph. CD44 expression and PI3K gene expression, both markers related to angiogenesis, were 3.5- and 1.8-fold higher, respectively, in cells cultured on sonication-degraded HA-Ph hydrogels than in those cultured on hydrogels comprising the original HA-Ph. These results highlight the potential of hydrogels containing sonication-degraded HA-Ph for tissue engineering and drug-screening applications involving human vascular endothelial cells.
Advancement in Cancer Vasculogenesis Modeling through 3D Bioprinting Technology
Authors: Shukla Arvind Kumar , Yoon Sik , Oh Sae-Ock , Lee Dongjun , Ahn Minjun , Kim Byoung Soo
Published: May 2024

Cancer vasculogenesis is a pivotal focus of cancer research and treatment given its critical role in tumor development, metastasis, and the formation of vasculogenic microenvironments. Traditional approaches to investigating cancer vasculogenesis face significant challenges in accurately modeling intricate microenvironments. Recent advancements in three-dimensional (3D) bioprinting technology present promising solutions to these challenges. This review provides an overview of cancer vasculogenesis and underscores the importance of precise modeling. It juxtaposes traditional techniques with 3D bioprinting technologies, elucidating the advantages of the latter in developing cancer vasculogenesis models. Furthermore, it explores applications in pathological investigations, preclinical medication screening for personalized treatment and cancer diagnostics, and envisages future prospects for 3D bioprinted cancer vasculogenesis models. Despite notable advancements, current 3D bioprinting techniques for cancer vasculogenesis modeling have several limitations. Nonetheless, by overcoming these challenges and with technological advances, 3D bioprinting exhibits immense potential for revolutionizing the understanding of cancer vasculogenesis and augmenting treatment modalities.
Valorization of Wheat Bran by Co-Cultivation of Fungi with Integrated Hydrolysis to Provide Sugars and Animal Feed
Authors: Mittermeier Fabian , Fischer Fabienne , Hauke Sebastian , Hirschmann Peter , Weuster-Botz Dirk
Published: May 2024

The enzymatic hydrolysis of agricultural residues like wheat bran enables the valorization of otherwise unused carbon sources for biotechnological processes. The co-culture of Aspergillus niger and Trichoderma reesei with wheat bran particles as substrate produces an enzyme set consisting of xylanases, amylases, and cellulases that is suitable to degrade lignocellulosic biomass to sugar monomers (D-glucose, D-xylose, and L-arabinose). An integrated one-pot process for enzyme production followed by hydrolysis in stirred tank bioreactors resulted in hydrolysates with overall sugar concentrations of 32.3 g L−1 and 24.4 g L−1 at a 25 L and a 1000 L scale, respectively, within 86 h. Furthermore, the residual solid biomass consisting of fermented wheat bran with protein-rich fungal mycelium displays improved nutritional properties for usage as animal feed due to its increased content of sugars, protein, and fat.
mTBI Biological Biomarkers as Predictors of Postconcussion Syndrome—Review
Authors: Stępniewska Ewelina , Kałas Maria , Świderska Justyna , Siemiński Mariusz
Published: May 2024

Postconcussion syndrome (PCS) is one of the leading complications that may appear in patients after mild head trauma. Every day, thousands of people, regardless of age, gender, and race, are diagnosed in emergency departments due to head injuries. Traumatic Brain Injury (TBI) is a significant public health problem, impacting an estimated 1.5 million people in the United States and up to 69 million people worldwide each year, with 80% of these cases being mild. An analysis of the available research and a systematic review were conducted to search for a solution to predicting the occurrence of postconcussion syndrome. Particular biomarkers that can be examined upon admission to the emergency department after head injury were found as possible predictive factors of PCS development. Setting one unequivocal definition of PCS is still a challenge that causes inconsistent results. Neuron Specific Enolase (NSE), Glial Fibrillary Acidic Protein (GFAP), Ubiquitin C-terminal Hydrolase-L1 (UCH-L1), Serum Protein 100 B (s100B), and tau protein are found to be the best predictors of PCS development. The presence of all mentioned biomarkers is confirmed in severe TBI. All mentioned biomarkers are used as predictors of PCS. A combined examination of NSE, GFAP, UCH-1, S100B, and tau protein should be performed to detect mTBI and predict the development of PCS.
Investigation on the Impacts of Three Sea Salt Ions on the Performance of CSA-OPC Binary System
Authors: Wang Chuanlin , Zhou Shupeng , Ou Qingyou , Zhang Yuxuan
Published: May 2024

This study aimed to explore the impact of three corrosive ions—SO42−, Cl−, and Mg2+—on the hydration property of calcium sulphoaluminate (CSA) cement. Cement paste was prepared using three types of sea salt ion solutions with varying concentrations as mixing water. The experimental program encompassed assessments of porosity, compressive/flexural strength, heat of hydration, pH of pore solution, XRD, and SEM analysis. To modulate the hydration environment, Ordinary Portland cement (10%) was incorporated to elevate the pH and enhance the stability of ettringite, thereby facilitating the formation of additional C-S-H gel for the observation of M-S-H and other compounds. Findings revealed that the Cl− accelerated the hydration of CSA, resulting in heightened heat release. However, it also decreased the length-to-diameter ratio of ettringite, leading to cracking in CSA test blocks. The addition of SO42− resulted in elevated internal alkalinity, prompting alterations in hydration product types and subsequent reduction in CSA strength. Conversely, Mg2+ was observed to ameliorate the microstructure of CSA test blocks, diminishing porosity and augmenting strength.
Nonlinear Dynamic Response of Galfenol Cantilever Energy Harvester Considering Geometric Nonlinear with a Nonlinear Energy Sink
Authors: Wang Lingzhi , Liu Chao , Liu Weidong , Yan Zhitao , Nie Xiaochun
Published: May 2024

The nonlinear energy sink (NES) and Galfenol material can achieve vibration suppression and energy harvesting of the structure, respectively. Compared with a linear structure, the geometric nonlinearity can affect the output performances of the cantilever beam structure. This investigation aims to present a coupled system consisting of a nonlinear energy sink (NES) and a cantilever Galfenol energy harvesting beam with geometric nonlinearity. Based on Hamilton’s principle, linear constitutive equations of magnetostrictive material, and Faraday’s law of electromagnetic induction, the theoretical dynamic model of the coupled system is proposed. Utilizing the Galliakin decomposition method and Runge–Kutta method, the harvested power of the external load resistance, and tip vibration displacements of the Galfenol energy harvesting model are analyzed. The influences of the external excitation, external resistance, and NES parameters on the output characteristic of the proposed coupling system have been investigated. Results reveal that introducing NES can reduce the cantilever beam’s vibration while considering the geometric nonlinearity of the cantilever beam can induce a nonlinear softening phenomenon for the output behaviors. Compared to the linear system without NES, the coupling model proposed in this work can achieve dual efficacy goals over a wide range of excitation frequencies when selecting appropriate parameters. In general, large excitation amplitude and NES stiffness, small external resistance, and small or large NES damping values can achieve the effect of broadband energy harvesting.
Research on Multi-Objective Optimization of Renovation Projects in Old Residential Areas Based on Evolutionary Algorithms
Authors: Zhang Jiaji , Shen Chuxiong , Tang Chao , Feng Liang , Chen Yuliang , Yang Shize , Ren Zhigang
Published: May 2024

Old residential areas present unique challenges in terms of design, stakeholders, and renovation requirements compared to traditional building projects. However, unreasonable construction plans can lead to delays, cost overruns, poor quality, and conflicts between the construction party and local residents. This article proposes an optimization model that prioritizes progress, quality, and cost as the key control objectives, leveraging the actual conditions of renovating old residential areas. The NSGA-II genetic algorithm is employed to solve the mathematical model. To validate the effectiveness and scientific rigor of the algorithm, a renovation project in an old residential area in Wuhan is used as a case study. The findings of this study offer valuable theoretical support for decision makers in selecting appropriate construction plans.
Risk Analysis and Simulation of Large Bridge Construction Based on System Dynamics
Authors: Fu Xu , Yang Meng , Liu Huanqin , Wang Lintai , Li Qian
Published: May 2024

To reduce risk incidents in large bridge construction, it is necessary to study the interaction mechanisms and dynamic changes among various risk factors during the construction of large bridges. First, the evolution mechanism of construction risks for large bridges is analyzed, and a risk factor structure system is established. Then, based on system dynamics theory, a causal loop diagram and flow–stock diagram are constructed, and system dynamics equations for each variable in the flow diagram are established to build a system dynamics model. Finally, taking a large bridge construction project as an example, the variable equations are assigned actual values, and the construction risk level is simulated and analyzed. The results show that, ➀ continuous investment in safety funds can effectively reduce the overall risk level of the system, ➁ changes in the management risk subsystem have a significant impact on the overall risk level of large bridge construction, and ➂ increasing the safety investment ratio in both the personnel risk subsystem and the management risk subsystem can effectively reduce the total risk level of the system.
Clinical and Genomic Features of Patients with Renal Cell Carcinoma and Advanced Chronic Kidney Disease: Analysis of a Multi-Institutional Database
Authors: Eule Corbin J. , Hu Junxiao , Hedges Dale , Jani Alkesh , Pshak Thomas , Manley Brandon J. , Sanchez Alejandro , Dreicer Robert , Myint Zin W. , Zakharia Yousef , Lam Elaine T.
Published: May 2024

Background: Patients with advanced chronic kidney disease (ACKD) are at an increased risk of developing renal cell carcinoma (RCC), but molecular alterations in RCC specimens arising from ACKD and overall survival (OS) in affected patients are not well defined. Patients and Methods: Using the Oncology Research Information Exchange Network (ORIEN) Total Cancer Care® protocol, 296 consented adult patients with RCC and somatic tumor whole exome sequencing were included. Patients with ACKD were defined as those with serum creatinine ≥1.5 mg/dL prior to RCC diagnosis. Results: Of 296 patients with RCC, 61 met the criteria for ACKD. The most common somatic mutations in the overall cohort were in VHL (126, 42.6%), PBRM1 (102, 34.5%), and SETD2 (54, 18.2%). BAP1 had a decreased mutational frequency in RCC specimens from patients without ACKD as compared to those with ACKD (10.6% versus 1.6%), but this was not statistically significant in univariable (OR 0.14, p = 0.056) or multivariable (OR 0.15, p = 0.067) analysis. Median OS was not reached in either cohort. Conclusions: Using the clinicogenomic ORIEN database, our study found lower rates of BAP1 mutations in RCC specimens from patients with ACKD, which may reflect a BAP1-independent mutational driver of RCC in patients with ACKD.
A Novel Positive-Contrast Magnetic Resonance Imaging Line Marker for High-Dose-Rate (HDR) MRI-Assisted Radiosurgery (MARS)
Authors: Wang Li , Ding Yao , Bruno Teresa L. , Stafford R. Jason , Lin Eric , Bathala Tharakeswara K. , Sanders Jeremiah W. , Ning Matthew S. , Ma Jingfei , Klopp Ann H. , Venkatesan Aradhana , Wang Jihong , Martirosyan Karen S. , Frank Steven J.
Published: May 2024

Magnetic resonance imaging (MRI) can facilitate accurate organ delineation and optimal dose distributions in high-dose-rate (HDR) MRI-Assisted Radiosurgery (MARS). Its use for this purpose has been limited by the lack of positive-contrast MRI markers that can clearly delineate the lumen of the HDR applicator and precisely show the path of the HDR source on T1- and T2-weighted MRI sequences. We investigated a novel MRI positive-contrast HDR brachytherapy or interventional radiotherapy line marker, C4:S, consisting of C4 (visible on T1-weighted images) complexed with saline. Longitudinal relaxation time (T1) and transverse relaxation time (T2) for C4:S were measured on a 1.5 T MRI scanner. High-density polyethylene (HDPE) tubing filled with C4:S as an HDR brachytherapy line marker was tested for visibility on T1- and T2-weighted MRI sequences in a tissue-equivalent female ultrasound training pelvis phantom. Relaxivity measurements indicated that C4:S solution had good T1-weighted contrast (relative to oil [fat] signal intensity) and good T2-weighted contrast (relative to water signal intensity) at both room temperature (relaxivity ratio > 1; r2/r1 = 1.43) and body temperature (relaxivity ratio > 1; r2/r1 = 1.38). These measurements were verified by the positive visualization of the C4:S (C4/saline 50:50) HDPE tube HDR brachytherapy line marker on both T1- and T2-weighted MRI sequences. Orientation did not affect the relaxivity of the C4:S contrast solution. C4:S encapsulated in HDPE tubing can be visualized as a positive line marker on both T1- and T2-weighted MRI sequences. MRI-guided HDR planning may be possible with these novel line markers for HDR MARS for several types of cancer.
Impact of Real-World Outpatient Cancer Rehabilitation Services on Health-Related Quality of Life of Cancer Survivors across 12 Diagnosis Types in the United States
Authors: Pergolotti Mackenzi , Wood Kelley C. , Kendig Tiffany D. , Mayo Stacye
Published: May 2024

Compared to adults without cancer, cancer survivors report poorer health-related quality of life (HRQOL), which is associated with negative treatment outcomes and increased healthcare use. Cancer-specialized physical and occupational therapy (PT/OT) could optimize HRQOL; however, the impact among survivors with non-breast malignancies is unknown. This retrospective (2020–2022), observational, study of medical record data of 12 cancer types, examined pre/post-HRQOL among cancer survivors who completed PT/OT. PROMIS® HRQOL measures: Global Health (physical [GPH] and mental [GMH]), Physical Function (PF), and Ability to Participate in Social Roles and Activities (SRA) were evaluated using linear mixed effect models by cancer type, then compared to the minimal important change (MIC, 2 points). Survivors were 65.44 ± 12.84 years old (range: 19–91), male (54%), with a median of 12 visits. Improvements in GPH were significant (p < 0.05) for all cancer types and all achieved MIC. Improvements in GMH were significant for 11/12 cancer types and 8/12 achieved MIC. Improvements in PF were significant for all cancer types and all achieved the MIC. Improvements in SRA were significant for all cancer types and all groups achieved the MIC. We observed statistically and clinically significant improvements in HRQOL domains for each of the 12 cancer types evaluated.
Lactococcus lactis subsp. cremoris C60 Upregulates Macrophage Function by Modifying Metabolic Preference in Enhanced Anti-Tumor Immunity
Authors: Saito Suguru , Cao Duo-Yao , Maekawa Toshio , Tsuji Noriko M. , Okuno Alato
Published: May 2024

Lactococcus lactis subsp. cremoris C60 is a probiotic strain of lactic acid bacteria (LAB) which induces various immune modifications in myeloid lineage cells. These modifications subsequently regulate T cell function, resulting in enhanced immunity both locally and systemically. Here, we report that C60 suppresses tumor growth by enhancing macrophage function via metabolic alterations, thereby increasing adenosine triphosphate (ATP) production in a murine melanoma model. Intragastric (i.g.) administration of C60 significantly reduced tumor volume compared to saline administration in mice. The anti-tumor function of intratumor (IT) macrophage was upregulated in mice administered with C60, as evidenced by an increased inflammatory phenotype (M1) rather than an anti-inflammatory/reparative (M2) phenotype, along with enhanced antigen-presenting ability, resulting in increased tumor antigen-specific CD8+ T cells. Through this functional modification, we identified that C60 establishes a glycolysis-dominant metabolism, rather than fatty acid oxidation (FAO), in IT macrophages, leading to increased intracellular ATP levels. To address the question of why orally supplemented C60 exhibits functions in distal places, we found a possibility that bacterial cell wall components, which could be distributed throughout the body from the gut, may induce stimulatory signals in peripheral macrophages via Toll-like receptors (TLRs) signaling activation. Thus, C60 strengthens macrophage anti-tumor immunity by promoting a predominant metabolic shift towards glycolysis upon TLR-mediated stimulation, thereby increasing substantial energy production.
Systematic Review of Beta-Lactam vs. Beta-Lactam plus Aminoglycoside Combination Therapy in Neutropenic Cancer Patients
Authors: Ishikawa Kazuhiro , Nakamura Tomoaki , Kawai Fujimi , Ota Erika , Mori Nobuyoshi
Published: May 2024

We performed a systematic review of studies that compared beta-lactams vs. beta-lactams plus aminoglycosides for the treatment of febrile neutropenia in cancer patients. Method: We searched CENTRAL, MEDLINE, and Embase for studies published up to October 2023, and randomized controlled trials (RCTs) that compared anti-Pseudomonas aeruginosa beta-lactam monotherapy with any combination of an anti-Pseudomonas aeruginosa beta-lactam and an aminoglycoside were included. Result: The all-cause mortality rate of combination therapy showed no significant differences compared with that of monotherapy (RR 0.99, 95% CI 0.84 to 1.16, high certainty of evidence). Infection-related mortality rates showed that combination therapy had a small positive impact compared with the intervention with monotherapy (RR 0.83, 95% CI 0.66 to 1.05, high certainty of evidence). Regarding treatment failure, combination therapy showed no significant differences compared with monotherapy (RR 0.99, 95% CI 0.94 to 1.03, moderate certainty of evidence). In the sensitivity analysis, the treatment failure data published between 2010 and 2019 showed better outcomes in the same beta-lactam group (RR 1.10 [95% CI, 1.01–1.19]). Renal failure was more frequent with combination therapy of any daily dosing regimen (RR 0.46, 95% CI 0.36 to 0.60, high certainty of evidence). Conclusions: We found combining aminoglycosides with a narrow-spectrum beta-lactam did not spare the use of broad-spectrum antibiotics. Few studies included antibiotic-resistant bacteria and a detailed investigation of aminoglycoside serum levels, and studies that combined the same beta-lactams showed only a minimal impact with the combination therapy. In the future, studies that include the profile of antibiotic-resistant bacteria and the monitoring of serum aminoglycoside levels will be required.
Enhancing the Visible Light Photocatalytic Activity of TiO2-Based Coatings by the Addition of Exfoliated g-C3N4
Authors: Papailias Ilias , Todorova Nadia , Giannakopoulou Tatiana , Plakantonaki Niki , Vagenas Michail , Dallas Panagiotis , Anyfantis George C. , Arabatzis Ioannis , Trapalis Christos
Published: May 2024

In the last few years, increasing interest from researchers and companies has been shown in the development of photocatalytic coatings for air purification and self-cleaning applications. In order to maintain the photocatalyst’s concentration as low as possible, highly active materials and/or combinations of them are required. In this work, novel photocatalytic formulations containing g-C3N4/TiO2 composites were prepared and deposited in the form of coatings on a-block substrates. The obtained photocatalytic surfaces were tested for NOx and acetaldehyde removal from model air. It was found that the addition of only 0.5 wt% g-C3N4 towards TiO2 content results in over 50% increase in the photocatalytic activity under visible light irradiation in comparison to pure TiO2 coating, while the activity under UV light was not affected. The result was related to the creation of a g-C3N4/TiO2 heterojunction that improves the light absorption and the separation of photogenerated electron-hole pairs, as well as to the inhibition of TiO2 particles’ agglomeration due to the presence of g-C3N4 sheets.
Influence of Surfactant Types on the Anti-Corrosion Performance of Phosphate Chemical Conversion Coated Mg-8wt.%Li Alloy
Authors: Cui Liji , Wang Baojie , Hou Jiyu , Xu Daokui , Sun Jie
Published: May 2024

In this work, the morphology, anti-corrosion performance and degradation mechanisms of two phosphate chemical conversion coatings containing the AEO (fatty alcohol polyoxyethylene ether) and AES (fatty alcohol polyoxyethylene ether sodium sulfate) on an as-cast Mg-8wt.%Li alloy were explored and compared. Although two coating layers had a petal-shaped structure and were composed of leaf-shaped particles, the coating layer of the AES-coated sample was relatively dense due to the smaller size of the formed petal-shaped structure. Based on the electrochemical data and hydrogen evolution measurements, the corrosion protectability of the coating layer on the AES-coated sample was better than that on the AEO-coated sample. The determined corrosion current densities (icorr) of the AES-coated and AEO-coated samples in the 3.5 wt.% NaCl solution were, respectively, 7.8 mA·cm−2 and 11.7 mA·cm−2, whereas the icorr value of the coated sample without a surfactant was 36.2 mA·cm−2.
Experimental Evaluation of Ceramic Coatings for Die Protection in Low-Pressure Die-Casting Process
Authors: López-Ortega Ainara , Areitioaurtena Olatz , Fuentes Elena , Igartua Amaya , Merchán Luis , Pardo Enrique , Montero Jessica , Granado Roberto , Martinez de la Pera Ignacio , Mendizabal Joannes , Zabala Borja
Published: May 2024

One of the most important factors in the LPDC process is the heat transfer during the solidification of the molten alloys, which is responsible for the resulting microstructure and, thus, the quality of the cast piece. The use of foundry coatings has been lately suggested as a proper strategy to control the heat transfer while protecting bonded moulds from aluminium adhesion by providing a barrier between the surface and the liquid metal. LPDC die coating failures usually come from the loss of adherence or excessive wear originated in the successive filling processes, which requires stopping production for the reapplication of the coating. In the present work, coatings with different insulation capabilities have been evaluated, in terms of adherence and wear tests, in order to select the most promising alternative for LPDC die coating. This study confirmed that surface preparation and cleanliness are vital for an adequate adhesion of the coatings to ensure their durability. The results evinced that the use of a primer layer provided a higher adhesion of the coatings and considerably improved their perfomance. The coating that presented the best results in terms of adhesion and wear resistance under different abrasive testing conditions was coating B3.
Preparation of n-Tetradecane Phase Change Microencapsulated Polyurethane Coating and Experiment on Anti-Icing Performance for Wind Turbine Blades
Authors: Wang Yiting , Shen He , Sun Zheng , Li Yan , Feng Fang
Published: May 2024

Icing is a common physical phenomenon, and the icing of wind turbine blades can significantly affect the performance of wind turbines. Therefore, researching methods to prevent icing is of great significance, and the coating method of anti-icing is an effective way to delay icing, with advantages such as low energy consumption and easy implementation. In this study, using the coating method as the background, tetradecane phase change microcapsules were prepared, with a melting enthalpy of 90.8 J/g and a crystallization enthalpy of 96.3 J/g, exhibiting good coverage and energy storage efficiency. After mixing tetradecane phase change microcapsules (PCMS) with polyurethane coating (PUR) and coating them on wind turbine blades, after a 5 min icing wind tunnel test, the coating could significantly delay the icing on the blade surface, with the highest anti-icing rate reaching 60.41%. This indicates that the coating has a good anti-icing effect and provides basic research data for exploring new anti-icing methods.
Steric Effects of Alcohols on the [Mn4O4] Cubane-Type Structures
Authors: He Yan , Zhou Zheng , Han Haixiang
Published: May 2024

[M4O4] (M = 3d transition metal) represents an interesting class of compounds featuring cubane-type molecular structures, and particularly, [Mn4O4] cubanes or their derivatives attract much attention by virtue of their potential applications as single-molecule magnets (SMMs) or catalysts. However, the rational design of desired cubane-related structures is still a challenging subject due to the lack of readily available methods to effectively tune the construction patterns of the molecule assembly. In this work, we report the employment of different alcohols to prepare three cubane-related molecules, Mn2(dhd)4(iPrOH)2 (1), Mn4(dhd)4(OEt)4(EtOH)4 (2) and Mn4(dhd)6(OMe)2(MeOH)2 (3) (dhd = 5,5-dimethyl-2,4-hexanedione). Interestingly, the bulkiest iPrOH leads to simple rhombic dimer molecule 1. It can be deemed a rudimentary structure oftetranuclear [Mn4O4] cubane 2, which can be realized by the use of less bulky EtOH. In addition, the least bulky MeOH promotes the assembly of the cubanes, eventually bringing about defective dicubane molecular cluster 3. The accurate crystal structures of 1–3 were modeled by single-crystal X-ray diffraction, and their electronic structures were investigated through absorption spectroscopy coupled with theoretical calculations. Overall, this work demonstrates a systematic study on controlling cubane-type structures of Mn-based compounds by applying different solvents, which provides a new means to design functional molecules for specific applications.