bluuebunny/crossref_metadata_2025 huggingface dataset:
Granulomatosis With Polyangiitis Involving the Fourth Ventricle: Report of a Rare Case and a Literature Review
Authors: Yuan Dan , Yang Xiao-rong , Li Ceng-fang , Ji Qing , Zhang Su-yuan , Wang Kai , Xia Jing-hua , Luo Suai Jin-jingWang , Wang Jin-jing
Published: February 2022

Background: Granulomatosis with polyangiitis (GPA) is a rare systemic autoimmune vasculitis disease that is highly correlated with antineutrophil cytoplasmic antibodies (ANCAs).It used to be called"Wegener's granulomatosis". The clinical manifestations are diverse, mainly involving the upper respiratory tract, lungs and kidneys, and this disease can involve the brain parenchyma as an isolated solid mass. Only one case has been reported thus far. To provide further information on this rare case, we report a case of granulomatous polyangiitis involving the fourth ventricle and review the relevant literature.Case characteristics: A 32-year-old Chinese female developed fever, cough, and shortness of breath for 20 days. An 8*8 cm skin ulcer was seen on the right lower limb. CT showed multiple large patches of increased density in both lungs. The patient’s serological anti-neutrophil cytoplasmic antibody cANCA was positive. Later, the patient developed dizziness and a headache. Magnetic resonance imaging of the head showed a mass of approximately 21x24 mm2 in the fourth ventricle. The patient had a craniotomy for mass resection, and macroscopically, the mass was gray–red and measured 2.5x2x2 cm and was soft, had local hemorrhage and necrosis, and had no capsule. The main microscopic features included necrotizing granulomatous vasculitis, the patient’s immunohistochemistry was positive for CD68 and negative for GFAP, and the acid-fast staining and hexaamine silver staining were negative. Combined with the clinical history, serology, and imaging, the pathological diagnosis was GPA in the fourth ventricle. The patient was switched to rituximab combined with steroid therapy because she did not tolerate cyclophosphamide. After 5 months of follow-up, the patient’s lung lesions and skin ulcers had completely improved, but the brain lesions had further progressed.Conclusion: When a patient has multiple system diseases, abnormal clinical manifestations, and positive serological ANCAs, a diagnosis of GPA should be carefully considered, and biopsies of easy-to-access sites should be performed. If the patient’s histopathological manifestations include necrotizing granulomatous vasculitis, a diagnosis of GPA is more likely. If a patient subsequently develops an intraventricular mass, the clinicians should consider a diagnosis of GPA, which can rarely involve the cerebral ventricle to avoid an unnecessary biopsy or surgical treatment of intracranial lesions. When a patient is intolerant to the traditional treatment drug cyclophosphamide and needs to be switched to rituximab, the treatment effect of intracerebral lesions is not ideal; therefore, the treatment of lesions involving GPA in the ventricle is worthy of further exploration.
Phb1 interacts with p53 in the regulation of mitochondrial dynamics and chemoresistance in gynecologic cancers
Authors: Kong Bao , Han Chae Young , Kim Se Ik , Patten David A , Han Youngjin , Carmona Euridice , Shieh Dar-Bin , Cheung Annie C. , Mes-Masson Anne-Marie , Harper Mary-Ellen , Song Yong Sang , Tsang Benjamin K.
Published: February 2022

Background: Mitochondrial dynamics (e.g. fission/fusion) play an important role in controlling chemoresistance in representative gynecologic malignancies, ovarian and cervical cancer. Processing the long form of Optic atrophy (L-Opa)1 is a distinctive character of mitochondrial fragmentation, associated with chemosensitivity. Here, we examined the role of prohibitin (Phb)1 in increasing L-Opa1 processing via the regulating mitochondrial protease, Oma1 and its direct interaction with p-p53 (ser15) and pro-apoptotic Bcl-2 antagonist/killer (Bak) 1 in the signaling axis and if this phenomenon is associated with prognosis of patients.Methods: We compared Cisplatin (CDDP)-induced response of mitochondrial dynamics, molecular interaction among p-p53 (ser15)-Phb1-Bak, and chemoresponsiveness in paired chemosensitive and chemoresistant gynecologic cancer cells (ovarian and cervical cancer cell lines) using western blot, immunoprecipitation, sea horse, and immunofluorescence. Translational strategy with proximity ligation assessment in phb1-p-p53 (ser15) in human ovarian tumor sections further confirmed in vitro finding, associated with clinical outcome.Results: We report that: (1) Knock-down of Phb1 prevents Cisplatin (cis‐diamine-dichloroplatinum; CDDP) -induced changes in mitochondrial fragmentation and Oma1 mediated cleavage, and Opa1 processing; (2) In response to CDDP, Phb1 facilitates the p-p53 (ser15)-Phb1-Bak interaction in mitochondria in chemosensitive gynecologic cancer cells but not in chemoresistant cells; (3) Akt overexpression results in suppressed p-p53(Ser15)-Phb1 interaction and dysregulated mitochondrial dynamics, and (4) Consistent with in vitro findings, proximity ligation assessment (PLA) in human ovarian tumor sections demonstrated that p-p53(ser15)-Phb1-Bak interaction in mitochondria is associated with better chemoresponsiveness and clinical outcome of patients. Determining the molecular mechanisms by which Phb1 facilitates mitochondrial fragmentation and interacts with p53 may advance the current understanding of chemoresistance and pathogenesis of gynecologic cancer.Conclusion: Determining the key molecular mechanisms by which Phb1 facilitates the formation of p-p53 (ser15)-Bak-Phb1 and its involvement in the regulation of mitochondrial dynamics and apoptosis may ultimately contribute to the current understanding of molecular and cellular basis of chemoresistance in this gynecologic cancer.
Severe Coagulopathy Caused By Cefminox Sodium: A Case Report
Authors: Wu Shuling , Bi Xiaoyue , Lin Yanjie , Yang Liu , Li Minghui , Yao Xie
Published: February 2022

A 55-year-old female patient with liver cirrhosis and hepatocellular carcinoma was treated with cefminox sodium for two times because of peritonitis. During the treatments, severe coagulopathy occurred, and the coagulation function quickly recovered after stopping the drug. The diagnosis and treatment of this patient provides us with ideas for dealing with similar problems in clinical practice in the future.
Solving Fundamental Life Testing Issues: An Application in Medical Science
Authors: Bakr M. E. , Gadallah A. M. , Al-Babtain Abdulhakim A.
Published: February 2022

In biomedical sciences, the application of probability models for survival experience has become increasingly significant. Survival models of classes of life distributions summarize the pattern of survival, recommend additional research, and offer theories and hypotheses. Nowadays, reliability is extremely crucial because complicated scientific gadgets, such as precise medical equipment, airplane equipment, and air defense equipment, are employed for exact scientific reasons. Furthermore, low or no reliability might result in an increase in the cost of device parts (spare parts), the loss of a person, or a threat to national security.
For decades, researchers have examined the use of the Laplace transform approach to test exponentiality. We proposed new tests for new better than utilized in expectation class in this post (NBUE). Critical values that have been censored and those that have not been censored are calculated. To evaluate the performance of this test, the powers for numerous regularly used alternatives are determined. The proposed test appears to have high efficacy and good powers for many regularly used alternatives. Finally, sets of medical real data are utilized to demonstrate how the proposed tests can be applied to solve real-world problems.
Fecal Metabolome and Bacterial Composition in Severe Obesity: Impact of Diet and Bariatric Surgery
Authors: Salazar Nuria , Ponce-Alonso Manuel , Garriga María , Sánchez-Carrillo Sergio , Hernández-Barranco Ana María , Redruello Begoña , Fernández María , Botella-Carretero José Ignacio , Vega-Piñero Belén , Galeano Javier , Zamora Javier , Ferrer Manuel , Gavilán Clara G. de los Reyes , Campo Rosa del
Published: February 2022

Background: The aim of this study was to monitor the impact of a preoperative diet and bariatric surgery on the bacterial gut microbiota composition and functionality in severe obesity and to compare sleeve gastrectomy (SG) versus Roux-en-Y gastric bypass (RYGB). The study also aimed to incorporate big data analysis for the omics results and machine learning by a Lasso-based analysis to detect the potential markers for excess weight loss.Methods: Forty patients who underwent bariatric surgery were recruited (14 underwent SG, and 26 underwent RYGB). Each participant contributed 4 fecal samples (baseline, post-diet, 1 month after surgery and 3 months after surgery). The bacterial composition was determined by 16S rDNA massive sequencing using MiSeq (Illumina). Metabolic signatures associated to fecal concentrations of short-chain fatty acids, amino acids, biogenic amines, gamma-aminobutyric acid and ammonium were determined by gas and liquid chromatography. Orange 3 software was employed to correlate the variables, and a Lasso analysis was employed to predict the weight loss at the baseline samples.Results: A correlation between Bacillota (formerly Firmicutes) abundance and excess weight was observed only for the highest body mass indexes. The crash diet had little impact on composition and targeted metabolic activity. RYGB had a deeper impact on bacterial composition and putrefactive metabolism than SG, although the excess weight loss was comparable in the two groups. Significantly higher ammonium concentrations were detected in the feces of the RYGB group. Conclusions: We detected individual signatures of composition and functionality, rather than a gut microbiota characteristic of severe obesity, with opposing tendencies for almost all measured variables in the two surgical approaches. The gut microbiota of the baseline samples was not useful for predicting excess weight loss after the bariatric process.
A Comparison between the Bayesian Network Model and the Logistic Regression Model in Prevention of the Defects on Ceramic Tiles
Authors: Sevinç Volkan , Kırca Meryem Merve
Published: February 2022

One of the most important problems occurring in ceramic tile industry is defective product problem. Defective ceramics leads to loss of income and waste of resources in enterprises. However, it is generally unknown which factors and production stages cause what kinds of defects. On the other hand, in the literature, the existing modeling studies usually consider the defects seen on industrial ceramics. The defect types of industrial ceramics and those of ceramic tiles are different. Moreover, the classification types encountered in both kinds of ceramics also differ from each other. This article investigates the reasons behind the defect occurrences on ceramic tiles, along with a comparison between a logistic regression model and a Bayesian network model. In the study, the model validation results of the logistic regression model and the Bayesian network model show that the Bayesian network model is more successful in estimating the defect types. Thus, the constructed Bayesian network model indicates that in general, the high speeds of the production band significantly increase the probabilities of all kinds of defects except the deformation defect. Additionally, the high densities of the glaze also increase the occurrence levels of the defects, except the deformation defect. Similarly, the high levels of the engobe weight and the engobe density are also among the factors increasing the defect occurrences.
Depressive symptoms and associated factors among public high school students in Bahir Dar City, Northwest Ethiopia: A cross-sectional study
Authors: Tarecha Debela , Mekonen Tesfa , Asnake Gizachew , Tarafa Hunde
Published: February 2022

Background: Depression is the most prevalent mental disorder in adolescents that lead to educational impairment, substance use problems, and suicidal attempts. The aim of this study was to assess depressive symptoms and their associated factors among public high school students in Bahir Dar city, Northwest Ethiopia.Methods: An institution-based cross-sectional study was conducted from March to April 2021 at Bahir Dar City public high school students. Data were collected from 781 participants using a self-administered questionnaire. Participants were selected using the multistage sampling method. Patient health questionnaire 9 modified for adolescents (PHQ-9A) was used to measure depressive symptoms. Data were analyzed using Statistical Package for Social Sciences (SPSS) version 25. Logistic regression analysis was done to identify factors associated with depressive symptoms. Variables with P-value <0.05 were considered statistically significant.Result: The prevalence of depressive symptoms were found to be 19.7% (CI=16.9, 22.6). Depressive symptoms were significantly associated with female sex (AOR=2.36, 95% CI=1.54-3.61), having known medical conditions (AOR=1.85, 95% CI=1.03-3.31), poor social support (AOR=1.83, 95% CI=1.03-3.31), childhood abuse (AOR=2.02, 95% CI=1.28-3.20) and neglect (AOR=2.78, 95% CI=1.70-4.55), and occupation of mother (AOR=0.38 CI=0.15-0.95).Conclusions: One in five public high students reported depressive symptoms. Schools need to institute routine mental health screening services and implement appropriate interventions to initiate and improve access to school-based mental health services, particularly for female students.
Quality of Life of Kazakhstan’s Population: Assessment of the Main Parameters and Identification of Problem Areas
Authors: Chulanova Zaure K.
Published: February 2022

The purpose of the article is to study the main parameters characterizing the quality of life of the population of Kazakhstan in modern economic conditions and develop proposals for its improvement. The methodology of the study is based on a holistic approach, including the use of objective indicators of the quality of life that determine the material conditions and means of human livelihood, and subjective assessments of the population, social groups of their material and social well-being. Measuring and evaluating the level and quality of life of the population of Kazakhstan based on an integrated approach includes the use of the following methods: component analysis, normative and stratification, integral indicators, and subjective assessments of the population. The leading blocks of the life support system are considered, including the assessment of income and consumption in the conditions of maintaining socio-economic income differentiation; the social qualitative parameters of the life support system of the population, the most important indicators of the implementation of priority areas of development of labor potential in the innovative economy, modernization of housing policy are given.
Next-Generation Antivirus endowed with Web-Server SandBox Applied to Audit Fileless Attack
Authors: Lima Sidney , Silva Sthéfano , Pinheiro Ricardo , Souza Danilo , Lopes Petrônio , Lima Rafael , Oliveira Jemerson , Monteiro Thyago , Fernandes Sérgio , Albuquerque Edison , Silva Washington , Santos Wellington
Published: February 2022

Background and Objective: Almost all malwares running on web-server are php codes. Then, the present paper creates a NGAV (Next Generation Antivirus) expert in auditing threats web-based, specifically from php files, in real time. Methods: In our methodology, the malicious behaviors, of the personal computer, serve as input attributes of the statistical learning machines. In all, our dynamic feature extraction monitors 11,777 behaviors that the web fileless attack can do when launched directly from a malicious web-server to a listening service in a personal computer. Results: Our NGAV achieves an average 99.95% accuracy in the distinction between benign and malware web scripts. Distinct initial conditions and kernels of neural networks classifiers are investigated in order to maximize the accuracy of our NGAV. Conclusions: Our NGAV can supply the limitations of the commercial antiviruses as for the detection of Web fileless attack. In opposition of analysis of individual events, our engine employs authorial Web-server Sandbox, machine learning, and artificial intelligence in order to identify malicious Web-sites.
Effects of COVID-19 Pandemic on Progress Test performance in German speaking countries.
Authors: Berlin Progress Test Medizin Charité Universitätsmedizin , Sehy Victoria , Atanet Iván Roselló , Sieg Miriam , Struzena Jana , März Maren
Published: February 2022

Background The COVID-19 pandemic has been the source of many challenges for medical students worldwide. The authors examined short-term effects on the knowledge gain of students in German speaking countries. Method The development of the knowledge gain of medical students during the pandemic was measured comparing the outcomes of shared questions within Berlin Progress Test (PT) pairs. The PT is a formative test of 200 multiple choice questions at graduate level, which provides feedback to students on knowledge and knowledge gain during their course of study. It is provided to about 11,000 students in Germany and Austria around the beginning of each semester. We analysed three successive test pairs: PT36-PT41 (both conducted before the pandemic), PT37-PT42 (PT37 took place before the pandemic; PT42 was conducted from April 2020 onwards) and PT38-PT43 (PT38 was administered before the pandemic; PT43 started in November 2020). The authors used mixed-effect regression models and compared the absolute variations in the percentage of correct answers per subject. Results The most recent test of each PT-pair showed a higher mean score compared to the previous test in the same pair (PT36-PT41: 2.53 (95% CI: 1.31-3.75), PT37-PT42: 3.72 (2.57-4.88), PT38-PT43: 5.66 (4.63-6.69)). Analogously, an increase in the share of correct answers was observed for most medical disciplines, with Epidemiology showing the most remarkable upsurge. Conclusion: Overall, PT performance improved during the pandemic, which we take as an indication that the sudden shift to online learning did not have a negative effect on the knowledge gain of students. We consider that these results may be helpful in advancing innovative approaches to medical education
Comprehensive Analysis of the Prognosis of S100 Family Members and Their Relationship with Tumor-Infiltrating Immune Cells in Human Pancreatic Adenocarcinoma
Authors: Ren Yajun , Chen Bing , Zhang Meng , Xu Feng
Published: February 2022

Background: S100 family members(S100s) are small molecular EF hand calcium binding proteins and widely expressed in many tissues and organs. S100s are shown to be biomarkers of disease progression and prognosis in various types of cancers. Nevertheless, the expression patterns, function, prognostic values of S100s and its association with tumor-infiltrating immune cells in Pancreatic Adenocarcinoma(PAAD) patients have not been systematically clarified. Methods: we explored that the expression and roles of the entire twenty S100s in PAAD patients by using the following public databases: Oncomine, GEPIA, cBioPortal, Metascape, STRING, TIMER and GeneMANIA.Results: The S100A2/A3/A4/A6/A8/A9/A10/A11/A13/A14/A16/B/P mRNA expression were significantly upregulated in PAAD patients. The mRNA expression of S100A3/A4/A5/A6/A10/A11/A14/A16/Z were significantly negatively related with the tumor stage in PAAD patients. We found that the S100A2/A3/A5/A10/A11/A14/A16 were significantly correlated with poor OS, whereas the increased levels of S100A1/B/G/Z were strongly associated with good OS. We found significant correlations among S100s and Tumor-Infiltrating Immune Cells. Cox proportional risk models revealed that B cells, Dendritic cells and S100A1/A5/A6/A8/A9/A13/A14 were significantly related with outcomes in PAAD patients. Conclusions: S100A2/A3/A10/A11/A14/A16 may serve as new diagnostic and prognostic biomarkers for PAAD patients and provide new clues for immunotherapy in PAAD patients.
Research progress on meibomian gland dysfunction from 2011 to 2020: a bibliometric and visualized analysis
Authors: Liu Qian , Zhao Fangkun , Kong Jun
Published: February 2022

Purpose: To explore the research areas, hotspots, and progress of meibomian gland dysfunction through bibliometrics.Methods: Related publications were retrieved from the Web of Science Core Collection from 2011 to 2020. VOSviewer1.6.16, Citespace.5.7. R2, and GraphPad Prism 8 were used to visualize the distribution of countries, research institutions, journals, authors, keywords, and annual publication numbers in this field.Results: A total number of 716 relevant publications were retrieved. The United States and Keio University ranked the first among the countries and organizations with the most publications. Cornea, Investigative Ophthalmology & Visual Science, and Ocular Surface were the top three journals with the highest publication counts and citations. The authors who contributed to this topic mainly formed three clusters which manifested the research areas, and the extracted keywords mainly formed four clusters which manifested the hotspots were explored. The research areas and hotspots of meibomian gland dysfunction were as follow: (1) Pathogenesis or potential etiology of meibomian gland dysfunction; (2) Diagnosis of meibomian gland dysfunction; (3) Therapy of meibomian gland dysfunction and the International Workshop`s dedication to it; (4) Epidemiology of meibomian gland dysfunction.Conclusions: In the last ten years, hundreds of publications revealed that the pathogenesis, diagnosis, epidemiology, and therapy were the research hotspots in meibomian gland dysfunction research area.
Multiscale Attribution Analysis of Urban Flood
Authors: Zhang Jinping , Wang Yuhao
Published: February 2022

In order to reveal the influence of the environment on urban flood, the rainfall and flood are decomposed to four components. Then the multiscale model of urban flood is constructed in the Jialu River Basin in Zhengzhou city of China. The results show that the underlying surface is the main driver of urban flood. Moreover, rainfall and flood volume basically retain a linear relationship in the first three components, and the impact of underlying surface is mainly reflected in a3. The multiscale model has good simulation effect and prediction effect.
PREDICTION OF RESIDUAL RESISTANCE OF A TRIMARAN VESSEL BY USING AN ARTIFICIAL NEURAL NETWORK
Authors:   Yildiz Technical University, Naval Architecture and Maritime Faculty, Istanbul, Turkey, Yildiz Burak
Published: February 2022

Trimaran hull forms have been popular recently in both commercial and military usage due to reduction in resistance at high speeds, better stability, and greater deck area compared to conventional monohull vessels. Determination of the location of the side hulls is most critical to get higher hydrodynamic performance. Therefore, many studies in the literature are related to defining the location of the side hulls for trimaran vessels. Most of the studies have been carried out experimentally or numerically. In this study, an artificial neural network (ANN) model was used to predict the residual resistance coefficient of a trimaran model. The model uses four parameters which are the transverse and longitudinal positions of the side hulls, the longitudinal centre of buoyancy and the Froude number to predict the residual resistance of the trimaran model. The experimental data of the trimaran model were used to train the neural network model in order to develop a more reliable model. Several neural network models were developed and tested to find the one with minimum error. The study showed that the residual resistance coefficients of the trimaran model were predicted with high accuracy levels compared to the model experimental data. It was also shown that an ANN is a useful alternative method to model tests and numerical simulations. The developed model can be used to reduce the number of model tests or numerical simulations as well as to obtain the optimum location of the side hulls in terms of resistance.
INFLUENCER SÖZLEŞMESİ
Authors: KESKİN Dilşad
Published: February 2022

Sanal ortamda belirli bir grubu etkileme gücüne sahip kimselerin hedef kitleyi ilgili ürünü satın almaya yönlendirmek amacıyla oluşturulan içerikleri sosyal medya hesaplarında paylaşmaları suretiyle yürütülen pazarlama ve reklam faaliyeti influencer marketing olarak isimlendirilmektedir. Bu faaliyetin merkezinde influencer yer alır. Influencer’in faaliyeti ise esasen müşteri ile aralarında kurulan bir sözleşmeye dayanmaktadır. Bu sözleşme; influencer’ın, belirli mal veya hizmetlerin tanıtımı ve takipçilerinin bunları satın almaya yönlendirilmesi amacıyla oluşturulan veya bizzat oluşturduğu içerikleri sosyal medya hesaplarında paylaşmayı, müşterinin de buna karşılık influencer’a bir miktar ücret ödemeyi veya başka bir menfaat sağlamayı taahhüt ettiği sözleşme olarak tanımlanabilir. Influencer sözleşmesinin temel unsurları; tanıtım ve reklam faaliyeti, sosyal medya kullanımı, influencer’ın müşterinin organizasyonundan bağımsız olması ve influencer’a bir bedel ödenmesi veya başka bir menfaat sağlanması şeklinde sayılabilir. Sözleşme, sponsorluk ve reklam sözleşmelerinden farklıdır. Taraf iradelerine göre vekalet veya eser sözleşmesi niteliği taşıyacak biçimde kurulması mümkün ise de kural olarak bir isimsiz sözleşmedir. Sözleşmeden doğan başlıca yükümlülükler ise, influencer bakımından, sosyal medyada belirli bir ürün veya hizmete yönelik olarak tanıtım amaçlı içerik paylaşımında bulunmak, paylaşımlarında reklam etiketi kullanmak, rekabet yasağına uygun hareket etmek ve faaliyetlerini sadakat ve özenle yürütmek, müşteri bakımından da influencer’in faaliyetlerinin karşılığını ödemektir.
Models of TV news layout: Different types of marketing narrative
Authors: Telenkov Dmytro , Krainikova Tetiana , Yezhyzhanska Tetiana
Published: February 2022

The study focuses on identifying and describing the layout models of leading Ukrainian TV channels, which were formed in 2004–2020 in connection with changes in audience demands, transformations of business models, and mastering the latest technologies. The news release is a marketing narrative about current events, mediated by narrators and language as a sign system. This paper aims to emotionally engage viewers and further communicate with them (including the consumption of television commercials). In 2019–2021, a rhetorical analysis of 531 news issues of the previously created sample of TV channels was performed. The semantic, structural, technological regularities and differences in the news layout are revealed. Based on a set of criteria (principles of selection and ranking of topics, methods of presenting information, broadcasting methods), the layout of the sample news is classified. Then a general description of TV news layout models is made. Five narrative models of the leading Ukrainian TV channels are substantiated: 1) hierarchical layout; 2) standard layout; 3) social layout; 4) stress layout; and 5) mixed layout. These models are related to the implementation of marketing tasks. Their understanding allows deepening the understanding of working with the audience, as well as improving news production in the television business.
Debts and corporate cash holdings: Evidence from ASEAN-5
Authors: Huong Giang Vuong Thi , Hang Dao Thuy , Thuy Hang Le Thi , Manh Nguyen Huu
Published: February 2022

This paper investigates the impact of debts on corporate cash holding levels and how this impact varies through five large markets of the ASEAN economic community due to different business environment features, namely, macroeconomic factors and legal characteristics. Using the Generalized Method of Moments for dynamic panel models to analyze mega data of non-financial ASEAN-5 firms from 2009 to 2018, this study examined that ASEAN-5 firms maintain relatively high cash after the financial crisis. Second, macroeconomic policies strongly affect the adjustment speed of corporate cash holdings and corporate cash reserve levels in ASEAN-5 firms. Besides, the estimates indicate that there is an alternative nexus between debts and cash reserves in ASEAN-5 firms. Finally, the impact of debts on corporate cash holdings is sustainably influenced by the macroeconomic conditions and the specific characteristics of the legal environment. This paper provides a rational framework for decision-making by corporate managers and macro-policymakers to solve the agency problems related to the alternative nexus between free cash flow and debt.
MONITORAMENTO DA QUALIDADE DA EDUCAÇÃO: AVALIAÇÃO E CONTROLE DO TRABALHO EDUCATIVO
Authors: Araújo Abelardo Bento
Published: February 2022

Este texto é parte de uma tese de doutorado em que se analisou a política de monitoramento da qualidade da educação em Minas Gerais, tendo em vista a especificidade da educação como processo de trabalho e como ação pedagógica. Com base em pesquisa documental e bibliográfica, discute-se neste texto o Estado Gerencial como matriz da gestão dos sistemas educacionais pautada na testagem de alunos em larga escala e na responsabilização de agentes educacionais. Verificam-se nessas políticas aspectos correspondentes à gerência, enquanto controle do trabalho alheio, aplicada ao trabalho educativo.
ESTUDO DE CASO DO ALMANAQUE AMBIENTAL MENINO CARANGUEJO: PRODUÇÃO, EXECUÇÃO E DISTRIBUIÇÃO PARA AS ESCOLAS PÚBLICAS DE JOINVILLE (SC)
Authors: José Francisco Peligrino Xavier
Published: February 2022

Esta publicação técnica pretende servir como registro da ação estratégica do Projeto Almanaque Ambiental Menino Caranguejo, como um estudo de caso que aponta desde a criação/ideia para execução e viabilização de um almanaque ambiental impresso, que foi distribuído gratuitamente para as escolas públicas da cidade de Joinville, Santa Catarina. O almanaque foi publicado em 23 edições, contendo histórias em quadrinhos inéditas da personagem Menino Caranguejo, e oportunizou a criação de novas personagens, chamadas de Turma do Mangue. Adicionalmente, foi realizado um trabalho na comunidade, por meio de palestras em escolas, tendo como focos o debate e a reflexão sobre a temática ambiental e o ecossistema manguezal, presente nos almanaques.
Expediente
Authors: Adriane Kasprowicz
Published: February 2022

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PROCESSO DE DESENVOLVIMENTO CLEANUP: PRODUTO PARA COMBATER A COVID-19 CLEANUP DEVELOPMENT PROCESS: PRODUCT TO COMBAT COVID-19
Authors: Viviane Gaspar Ribas El Marghani  , Lívia Cozer Montenegro  , Cynthia do Prado Vendruscolo  , Leila Diniz  , Vinicius Brunning
Published: February 2022

Com a pandemia da Covid-19 decretada no mundo, um grupo de designers reuniu-se remotamente com especialistas de diferentes áreas e localizações geográficas, com o objetivo de desenvolver um produto inovador e confiável que ajudasse a população na prevenção da doença e no controle da dispersão da Covid-19 recente. Por meio do gerenciamento de projeto ágil e de outras ferramentas e dinâmicas já bem conhecidas no design de desenvolvimento de produto, a equipe de especialistas apresenta neste artigo o potencial e os desafios do desenvolvimento de produtos CleanUp em tempo hábil. Como principal resultado, destaca-se que a gestão ágil de projetos com equipes multidisciplinares trabalhando remotamente foi capaz de auxiliar o grupo com resultados rápidos e eficazes para o desenvolvimento do CleanUp.
DESIGN ERGONÔMICO E O DESENVOLVIMENTO DE ARTEFATOS DE USO COTIDIANO: PERCEPÇÃO E SEMÂNTICA
Authors: João Vítor de Andrade Scardovelli  , Thiago Almeida  , Rodolfo Nucci Porsani  , Fausto Orsi Medola  , Luis Carlos Paschoarelli
Published: February 2022

O design ergonômico pode ser um importante método para desenvolver produtos de uso cotidiano que sejam satisfatórios de usar. Um de seus principais preceitos é utilizar recursos para avaliar as alternativas de artefato desenvolvidas. O presente estudo objetivou relatar o desenvolvimento de um espremedor de frutas cítricas manual considerando a aplicação dos métodos do design ergonômico e os aspectos de usabilidade. Inicialmente, avaliaram-se três diferentes produtos de mercado por meio do protocolo de diferencial semântico. O desenvolvimento do projeto de produto contou com brainstorming, sketches, escaneamento em três dimensões (3D), modelagem digital e prototipagem rápida (impressão 3D). O protótipo foi avaliado com o mesmo protocolo de diferencial semântico em condições controladas (laboratório), com oito participantes. Os resultados apontam que o artefato contemplou os fatores positivos desejados no projeto inicial e mostram que a metodologia de design ergonômico pode proporcionar produtos de uso cotidiano que oferecem experiências mais prazerosas e satisfatórias.
Entre o ensino de História e a educação patrimonial: em busca da investigação de bens culturais locais
Authors: Édina Francini Simão Hack
Published: February 2022

Compartilhar a experiência vivenciada com os alunos do curso de Pedagogia por meio da investigação de bens culturais locais que buscou promover a reflexão sobre outras possibilidades de ensinar e aprender História é um dos objetivos do artigo. A metodologia utilizada quanto aos objetivos foi pesquisa exploratória, e quanto aos procedimentos, pesquisa bibliográfica e de campo. É preciso superar um modelo de ensino de História que não instiga o aluno a compreender-se como sujeito da história. Ensinar História por meio do patrimônio cultural contribui para o processo de formação do conceito de identidade, bem como para a preservação e a valorização da memória e história local, imprescindíveis para o exercício da cidadania.
Patrimônio e bem-estar social: o centro histórico de Niterói (RJ)
Authors: Regina Celia da Silva Costa
Published: February 2022

O presente artigo busca colaborar com a revitalização do centro histórico da cidade de Niterói (RJ), por meio de uma reflexão sobre seu patrimônio cultural e a relação que mantém com seus habitantes. Pretendemos enfatizar como a percepção de integração e pertencimento reforça o bem-estar social, contribuindo ativamente para a promoção da cidadania e da autoestima. A melhora qualitativa dos espaços urbanos é fator preponderante no desenvolvimento da coletividade como um todo e na promoção de riquezas em diversos níveis, do econômico ao cultural.
Obra e olhar: as fotografias de Louise Lawler como obstáculo entre o olhar espetacularizado e a obra codificada
Authors: Gabriel Couto Sampaio
Published: February 2022

Este artigo busca compreender a relação entre os espaços de circulação de obras de arte e a obra da artista estadunidense Louise Lawler. O trabalho pretende situar e analisar o alcance da obra da artista e como sua produção visual permite o reconhecimento de leituras desviantes sobre obras de arte por meio das diferentes sintaxes expositivas em que elas estão inseridas. A discussão acerca de mercado de arte, colecionismo e apropriação também ganha contornos expressivos na reflexão aqui delineada.
Museu da Língua Portuguesa: tecnologia como atratividade turística na cidade de São Paulo
Authors: Airton José Cavenaghi  , Alline Mirna Nascimento  , Vanessa Bruna Pereira
Published: February 2022

Esta pesquisa, de caráter exploratório e qualitativo, com referencial documental bibliográfico e uso de entrevistas de campo semiestruturadas, visou identificar a influência da tecnologia sobre a atratividade turística na cidade de São Paulo, utilizando como objeto de estudo o Museu da Língua Portuguesa, por ser um dos museus que utilizam instalações altamente interativas e tecnológicas em seu acervo. As referências bibliográficas apresentam os principais conceitos de turismo, hospitalidade e patrimônio cultural. E, por surgir o conceito de turismo virtual, menciona-se como tal atividade se desenvolve. Como principal objeto de estudo, a história da formação e os principais atrativos do Museu da Língua Portuguesa são apresentados no decorrer do trabalho, além do modo como a tecnologia influencia suas exposições. Os resultados das pesquisas de campo mostram que a interatividade aumenta a percepção do público perante o que é exposto e que a tecnologia é um importante elemento de diferenciação com relação ao museu tradicional, funcionando como fator de atratividade turística.
Editorial
Authors: Adriane C. Kasprowicz
Published: February 2022

Editorial
Valorização e preservação de ladrilhos hidráulicos do período art déco brasileiro presentes no centro histórico de Santa Maria (RS)
Authors: Marcele Della Flora Cortes  , Caryl Eduardo Jovanovich Lopes
Published: February 2022

O ladrilho hidráulico foi um importante revestimento decorativo, muito utilizado não só no Brasil, como no mundo todo. É uma forma de manifestação artística e produção manual atemporal que persiste até os dias atuais. O presente artigo busca, nesse sentido, colaborar com a conscientização, o conhecimento e a preservação do uso do ladrilho hidráulico do período art déco do centro histórico da cidade de Santa Maria (RS), por meio de uma reflexão sobre o patrimônio cultural e a importância da preservação desse bem.
Intervenções urbanas: a arte aponta para o futuro
Authors: Dalvit Greiner de Paula
Published: February 2022

Este artigo propõe-se a discutir a cidade como o lugar do encontro e do exercício do direito. Por constituir tal lugar, a cidade não pode escolher quem pretende ser parte dela, mas deve acolher com dignidade todos aqueles que a buscam por segurança e, em troca, oferece seus talentos. Dessa maneira, criando uma cultura oposta à rusticidade rural, a principal característica da cidade é ser plural e diversa. Pensar a homogeneidade significa pensar a morte da cidade. O grande desafio é garantir o acesso e a fruição da cultura e do espaço urbano, uma vez que nem todos usufruem igualmente o direito à cidade. Trata-se, pois, de indagar como e por que vários grupos e espaços foram sendo invisibilizados pelo capital, impedindo os cidadãos de se apropriarem dos espaços públicos. Essas reflexões, entre outros aspectos, mostram-nos como as intervenções artísticas urbanas, surgidas na segunda metade do século XX, resultam de uma nova consciência política contestatória, tanto do liberalismo quanto do socialismo, e propõem novas formas de ver e sentir a cidade, consolidando a ideia de intervenção urbana como estratégia de transformação física e tática de uso da cidade e da sua cultura.
Editorial
Authors: Adriane C. Kasprowicz
Published: February 2022

Editorail
Expediente
Authors: Adriane C. Kasprowicz
Published: February 2022

Expediente
Antibacterial effect of mouthwashes against Streptococcus mutans, Staphylococcus aureus and Enterococcus faecalis
Authors: Vanessa de Sousa  , Orlando Aguirre Guedes  , Lucas Rodrigues de Araújo Estrela  , Luis Evaristo Ricci Volpato  , Alexandre Meireles Borba  , Cyntia Rodrigues de Araújo Estrela
Published: February 2022

Mouthwashes are one of the resources for controlling oral microbiota. They can reduce microorganisms, because they have antibacterial action and can access microorganisms even in areas of greater difficulty in the oral cavity. Objective: Antibacterial effect of some mouthwashes commonly used–0.12% chlorhexidine gluconate, 0.07% cetylpyridinium chloride, a solution based on essential oils (Listerine Zero), a solution of 1.33 mg benzethonium chloride / 25 mg hydrochloride lidocaine, a solution-based essential oils (Malvatricin) and 0.12% chlorhexidine + cetylpyridinium (Noplax)–was evaluated by means of agar diffusion and direct exposure tests. Material and methods: Strains of Streptococcus mutans (ATCC 27853), Staphylococcus aureus (ATCC 6538) and Enterococcus faecalis (ATCC 29212) were used in this study. For the agar diffusion test, Petri dishes with brain heart infusion agar (BHIA) were inoculated with the microbial suspensions. Sterile paper disks were immersed in the experimental for 1 min and then placed on the surface of BHIA. After incubation at 37ºC for 48 h, the diameters of the microbial inhibition halos were measured. For direct exposure test, no. 50 sterile absorbent paper points were immersed in the bacterial suspension for 5 min and then placed in Petri dishes and covered with 10 Ml of one of the tested solutions. At intervals of 1, 5, 10 and 30 min, absorbent paper points were removed from contact with substances and immersed in 7 mL of Letheen Broth and incubated at 37ºC for 48 h. Microbial growth was assessed by the turbidity of the culture medium. Results: The agar diffusion test showed inhibition halos greater than 10 mm for all substances against bacteria. In the direct exposure test, 0.12% chlorhexidine gluconate, 0.07% cetylpyridinium chloride, and 0.12% chlorhexidine associated with cetylpyridinium showed antibacterial effect on all the tested microorganisms after 10 min. Conclusion: The tested solutions showed antimicrobial effect on the biological indicators. The solutions of 0.12% chlorhexidine gluconate, 0.07% cetylpyridinium chloride and 0.12% chlorhexidine associated with cetylpyridinium showed antimicrobial effect on all biological indicators after 10 min.
Alta prevalência de quartos canais não tratados e forames independentes em primeiros molares superiores e associação com lesões periapicais: um estudo transversal
Authors: Anderson de Oliveira Paulo  , Laís Medeiros Barriviera  , Fernando Antunes Barriviera  , Mauricio Barriviera  , Isabella Figueira de Sousa  , Loise Pedrosa Salles  , Igor Iuco Castro-Silva
Published: February 2022

O conhecimento sobre a ocorrência do segundo canal mesiovestibular (MV2) em dentes já tratados é insuficiente, e variações anatômicas do forame apical representam um grande desafio para o endodontista, o que pode estar associado a altas taxas de falha clínica. Objetivo: Este estudo objetivou determinar a prevalência de quartos canais tratados e forames apicais independentes em primeiros molares superiores permanentes com tratamento endodôntico e sua associação com lesões periapicais, usando tomografia computadorizada de feixe cônico (TCFC) em campo de visão pequeno. Material e métodos: O total de 1.100 primeiros molares superiores permanentes com tratamento endodôntico de diferentes pacientes da cidade de Brasília (DF, Brasil) foi analisado em imagens de TCFC por dois examinadores calibrados e especialistas em imaginologia. A presença do canal MV2 foi registrada e classificada nas variáveis categóricas com ou sem tratamento, com ou sem forame apical independente e com ou sem lesão periapical, e suas frequências foram analisadas pelo teste do χ2 (p < 0,05) e razão de chances. Resultados: Houve proporção discrepante de canais MV2 tratados e não tratados (razão de 1:6,5) e MV2 com forame independente presente e ausente (razão de 1,4:1). A associação entre lesões periapicais com quartos canais não tratados e forame apical independente foi significativamente forte e positiva. Conclusão: Este estudo demonstrou a alta prevalência de canal MV2 sem tratamento e forame apical independente em primeiros molares superiores permanentes com tratamento endodôntico e sua associação com lesões periapicais em análise por TCFC. Esses achados apontam para a necessidade de se reforçar procedimentos de diagnóstico e tratamento em endodontia.
Signaling pathways involved in tooth development: why use zebrafish in dental research?
Authors: Sabrina Schulze  , Erika Calvano Küchler  , Rafaela Scariot  , Flares Baratto-Filho  , Julia Carelli  , Peter Proff  , Christian Kirschneck
Published: February 2022

Zebrafish (Danio rerio, formerly named Brachydanio rerio) is an established model organism used in health research for a long time. In the past decades, some research groups have been using zebrafish model to understand the genes involved in tooth development. Objectives: To introduce zebrafish as an animal model for tooth development researchers and to highlight the advantages and limitations of this model. Literature review: Tooth development (also known as odontogenesis) is a complex process that relies on precise control of several critical regulatory pathways. Because of the complex development and morphogenesis of teeth, many human developmental dental anomalies arise due to disruptions during tooth development. The knowledge regarding signaling pathways and genes expressed during tooth development has mainly been discovered using mice (not modified and genetically modified) and other rodents. Zebrafish (Danio rerio, formerly named Brachydanio rerio) has also been used by some recent researchers. Results: Zebrafish as a model organism has several advantages, and for which a large and diverse set of genetic and molecular tools are already available. Zebrafish has an easy husbandry system and a relatively fast embryonic development. Conclusion: This review provides some insights for the use of zebrafish in understanding tooth development and developmental dental alterations for clinical and basic researchers alike.
Granuloma piogênico atípico: diagnóstico e tratamento cirúrgico
Authors: Demóstenes Alves Diniz  , Jéssica da Silva Cunha  , Thawan Lucas Rodrigues Mendonça  , Vitória Helena Sales do Nascimento  , Caio César Gonçalves Silva  , Kalyne Kelly Negromonte Gonçalves  , Fernando Antônio Cardoso Maciel
Published: February 2022

O granuloma piogênico representa uma lesão relativamente comum na mucosa oral e de natureza não neoplásica. Em termos clínicos, apresenta-se inicialmente como uma pequena pápula que evolui dando lugar a uma massa nodular exofítica, séssil ou pediculada, com cores que variam de rosa a vermelho e azul, de acordo com a idade da lesão e da sua vascularização, assumindo aspecto sangrante ou ulcerado mesmo diante de trauma mínimo. Objetivo: O presente trabalho teve como objetivo relatar o caso clínico de um paciente pediátrico com granuloma piogênico em lábio inferior, discutindo o diagnóstico com base em características clínicas e histopatológicas, manejo cirúrgico e tratamento da lesão. Relato de caso: Paciente, 8 anos de idade, gênero masculino, portador de hábitos parafuncionais de sucção e mordiscamento de lábio, apresentava lesão exofítica, consistência endurecida, indolor e sangrante ao toque, em região lateral direita de lábio inferior. Submetido à cirurgia sob anestesia local (biópsia excisional) para tratamento definitivo da lesão. Conclusão: A etiologia para as lesões orais é a mais variável possível. O granuloma piogênico caracteriza-se como uma lesão com atividade hiperplásica excessiva resultante muitas vezes de um trauma, que pode ser de baixo grau, como o hábito de mordiscar os tecidos orais, da presença de um corpo estranho ou até mesmo da ineficiência da técnica de escovação empregada.
Práticas de higiene bucal aplicadas a pacientes sob ventilação mecânica: revisão de literatura
Authors: Gabriela dos Santos Ribeiro Rocha  , Márcia Cristina da Silva  , Thais Akemi Sako  , Suzana Goya
Published: February 2022

A pneumonia por ventilação mecânica é comum e importante e acomete pacientes hospitalizados em unidades de terapia intensiva. A higiene bucal é um fator que contribui para essa condição. Objetivo: Avaliar quais métodos de higienização bucal são utilizados nas unidades de terapia intensiva em pacientes sob ventilação mecânica e suas influências sobre a pneumonia associada à ventilação mecânica. Material e métodos: Elaboraram-se três estratégias de busca e estas foram aplicadas nas bases de dados Literatura Latino-Americana em Ciências da Saúde (LILACS), PubMed e Biblioteca Eletrônica Científica Online (SciELO). Foram incluídos ensaios clínicos que avaliavam os métodos de higienização bucal realizados nas unidades de terapia intensiva. Após as buscas, os dados dos artigos foram sintetizados. Resultados: Foram identificados 1.883 estudos. Após exclusões, incluíram-se 12 artigos para revisão. Os métodos de higienização citados nos estudos foram escovação com escova dental, limpeza com esponja, uso de creme dental e soluções com ação antimicrobiana. Conclusão: O método de higienização químico mais usado nos estudos foi o digluconato de clorexidina, e o método mecânico, a escovação com escova dental. A clorexidina apresentou maior redução da infecção do trato respiratório.