bluuebunny/crossref_metadata_2025 huggingface dataset:
Light-Sheet Fluorescence Imaging Reveals Three-Dimensional Amyloid Burden Reduction Following Five Weeks of Swimming Exercise in Alzheimer’s Mouse
Authors: Son Hye Joo , Lee Suk Hyun
Published: January 2025

Emerging evidence from observational studies suggests that lifestyle modifications, particularly moderate-intensity exercise, may confer neuroprotective benefits against dementia, potentially by enhancing brain resistance through clearance mechanisms. Using light-sheet fluorescence microscopy (LSFM) with tissue clearing, we investigated the role of voluntary swimming in ameliorating β-amyloid pathology in a transgenic Alzheimer’s disease (AD) mouse model. Twenty 52-week-old hAPPsw mice were randomly divided into a 5-week voluntary swimming intervention group and a control group (each n = 10). Each session included a 10-min swim followed by a 10-min rest, escalating from one session per day in the first week to three sessions per day by the fifth week. The excised brains were prepared using tissue-clearing and volume immunostaining with thioflavin-S for β-amyloid. For LSFM imaging, the individual plaque area and volume, total plaque load, and morphological parameters were quantified via an Imaris-based three-dimensional (3D) volumetric surface model. Visual comparison revealed that the intervention group presented significantly lower β-amyloid accumulation. The total surface volume of β-amyloid accumulation in the intervention group was significantly lower than that of the control group (intervention, 122,180,948 μm3 [105,854,660–169,063,081]; control, 167,201,016 μm3 [139,367,765–193,535,450]; p = 0.043). There were no significant differences in the morphological parameters, such as ellipticity and sphericity. Our LSFM study demonstrated notable reductions in β-amyloid, as evidenced by a decrease in total surface volume, in 52-week-old transgenic mice after a 5-week structured swimming program, supporting the notion that even in advanced AD stages, leisure-time voluntary swimming serves as an efficacious intervention for augmenting resistance to pathology.
Emotional Intelligence and Critical Thinking: Relevant Factors for Training Future Teachers in a Chilean Pedagogy Program
Authors: Palma-Luengo Maritza , Martin Nelly Lagos-San , Ossa-Cornejo Carlos
Published: January 2025

Critical thinking has become one of the most notable cognitive skills in education in recent decades since it offers skills for improving knowledge, making decisions, and creativity, among others. While it is considered a mainly cognitive process, recent years have seen strong proposals regarding its relationship with motivational and emotional processes. A study is presented that analyzes the relationship between critical thinking and emotional intelligence, analyzing the relations and influences between these variables. Two instruments were applied to 658 Chilean pedagogy students with ages ranging from 19 to 47 years old. The results indicate a moderate level of critical thinking and a high level of emotional intelligence, along with a positive and significant but moderately low relationship between emotional intelligence and critical thinking. There are no gender differences, meaning that men and women developed these skills in a similar way, but differences were found between age groups. The study highlights the relevance of promoting both critical thinking and emotional intelligence in training future teachers and the need to generate new studies about how these skills are developed in teacher training.
Secrets from the Depths of Space and Earth: Unraveling Newly Discovered High-Pressure Polymorphs in Meteorites and Diamond Inclusions
Authors: Pushcharovsky Dmitry , Bindi Luca
Published: January 2025

Significant recent discoveries of a large group of high-pressure (HP) minerals are reviewed. These minerals can be classified into two genetic types: those formed in shocked meteorites and impact craters and those formed under static P-T conditions and found as inclusions in diamonds. Of particular interest are the HP-polymorphic modifications of minerals such as olivine, ilmenite, ulvöspinel, wollastonite, and feldspars. Some examples include asimowite, poirierite, ohtaniite, liuite, wangdaodeite, tschaunerite, breyite, davemaoite, lingunite, and liebermannite. Special attention is also devoted to new dense hydrous silicates, which show much better stability than other known hydrous minerals to act as water reservoirs in the early stage of Earth’s geological history. The crystal structures and compositions of these new HP-minerals provide valuable insights into the complex petrology of deep geospheres, otherwise not obtainable in laboratory experiments. Using such a rich database, further steps became appropriate and possible toward the directions of a more advanced knowledge of evolution, composition, and structure of Earth.
Assessing the Roles of Retinol, Vitamin K2, Carnitine, and Creatine in Plant-Based Diets: A Narrative Review of Nutritional Adequacy and Health Implications
Authors: Goldman David , Warbeck Cassandra , Barbaro Robby , Khambatta Cyrus , Nagra Matthew
Published: January 2025

Plant-based diets are associated with numerous health benefits, including reduced risks of chronic diseases. However, questions persist regarding the implications of lower dietary intakes of certain non-essential nutrients, such as retinol, vitamin K2, carnitine, and creatine, which are primarily found in animal-derived foods. This narrative review evaluates the roles of these nutrients in human physiology and examines whether their absence in plant-based diets is likely to impact health outcomes. Retinol requirements can be met through the consumption of provitamin A carotenoids in plant foods, even in individuals with reduced conversion efficiency. Endogenous synthesis adequately supports physiological needs for vitamin K2, and currently available evidence does not consistently demonstrate that dietary vitamin K2 provides additional benefits for bone or cardiovascular health. Carnitine and creatine levels may differ between individuals following omnivorous and plant-based diets, but these differences do not result in compromised muscle function, cognitive health, or metabolic outcomes. Current evidence does not indicate that the absence of these non-essential nutrients in plant-based diets adversely affects health or confers disadvantages compared to omnivorous diets.
Dietary Inflammatory Score (DIS)’s and Lifestyle Inflammatory Score (LIS)’s Impact on Multiple Sclerosis Severity
Authors: Guglielmetti Monica , Ferraris Cinzia , Neri Lenycia de Cassya Lopes , Frias-Toral Evelyn , Tagliabue Anna , Tavazzi Eleonora , La Malfa Alessandro , Greco Giacomo , Bergamaschi Roberto , Zambrano-Villacres Raynier , Grosso Giuseppe
Published: January 2025

Background/Objectives: Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system with variable degrees of inflammation and gliosis. Diet and lifestyle factors could influence MS development and also contribute to inflammation. The current study aims to evaluate the relationship between dietary and lifestyle inflammatory potential and multiple sclerosis severity. Methods: A cross-sectional study design was employed. Data collection included demographic, neurological, and nutritional information. The Dietary Inflammatory Score (DIS) and Lifestyle Inflammatory Score (LIS) were calculated based on the reference protocol. Results: One hundred and seven participants (69.2% female; mean age, 50.6 ± 11.6 years) completed the study. The anti-inflammatory LIS group had significantly higher proportions of normal-weight (p = 0.000) and physically active (p = 0.022) participants. A greater proportion of women exhibited an anti-inflammatory lifestyle compared to men (80% vs. 20%; p = 0.023). No relation was retrieved between the DIS, LIS, and MS Severity Score (MSSS). When analyzing the single DIS components, leafy greens were associated with MS severity (OR 1.67; 95% CI, 1.50–18.74; p = 0.009). Among the LIS components, “high physical activity” (OR 5.51; 95% CI, 1.66–18.30; p = 0.005) and “heavy drinking” (OR 5.61; 95% CI, 1.19–26.47; p = 0.029) were related to lower MS severity. Conclusions: Although no differences were found in the total Dietary and Lifestyle Inflammatory Scores, some of their components might be connected with MS severity. Further intervention studies are needed to validate these findings.
Nutritional Characterisation of Childhood Chronic Kidney Disease: Trace Element Malnutrition in Paediatric Renal Disease (TeMPeReD) Study
Authors: Harmer Matthew J. , Wootton Stephen A. , Gilbert Rodney D. , Anderson Caroline E.
Published: January 2025

Background/Objectives: In chronic kidney disease (CKD), poor nutrition is associated with poorer clinical outcomes. There are limited data on milder stages of childhood CKD. Methods: This study characterised the nutritional state of a cohort of children with CKD. Results: Within the cohort (mean age 10.5 years, mean eGFR = 57 mL/min/1.73 m2), obesity defined by body mass index rates was comparable to that in the general population, but central obesity (waist-to-height ratio > 0.5) was evident in 44% of children. Although average nutrient intakes for the cohort were acceptable, there was marked variability in the risk of poor nutrient intake (<LRNI): selenium (35%), magnesium (35%), iodine (30%), and zinc (30%). No child met the recommended dietary fibre intake. The prevalence of frank deficiency of vitamins and minerals in blood concentrations was low. Blood concentrations of vitamins A and E were near-universally elevated. In those who had a decline in kidney function at the 12-month follow-up, dietary intake of fibre correlated with the degree of decline. Conclusions: Much work is needed to optimise the nutritional status of children with CKD as an important modifiable risk factor for disease progression and other important outcomes.
Women with Autoimmune Thyroiditis Taking Levothyroxine During Pregnancy: Is Iodine Supplementation Needed?
Authors: Censi Simona , Messina Giulia , Feligiotti Emma , Clausi Cristina , Piva Ilaria , Basso Daniela , Merante Boschin Isabella , Bertazza Loris , Battheu Fiammetta , Barollo Susi , Camilot Marta , Mian Caterina
Published: January 2025

Background: Iodine is fundamental for the synthesis of thyroid hormones, which play a central role in foetal neurological development. The need for an iodine-containing supplement (ICS) in L-T4-treated women during pregnancy is still a subject of debate. Aim of the Study: The aim of the study is to investigate the iodine status in women with autoimmune thyroiditis (AT) who have or have not been treated with L-T4. Methods: This was a cross-sectional, observational study involving pregnant women with AT, treated with/without L-T4. Upon enrolment, women provided a urine sample (to measure the urinary iodine concentration (UIC), which was normalised to urinary creatinine values (UI/Creat)), and completed a questionnaire. TSH, FT4, and neonatal TSH were also obtained. Results: Among women taking an ICS, 74.1% had a UI/Creat level ≥ 150 μg/g, compared with only 46.2% of those not taking an ICS (p = 0.03). Among L-T4 users only, a UI/Creat level ≥ 150 μg/g was more frequent in ICS users than in non-ICS users (72.8% vs. 41.7%) (p = 0.03). In the multivariate analysis, ICS use was the only independent variable for UI/Creat ≥ 150 μg/g (OR: 3.4; CI: 1.1–10.9) (p = 0.04). There was a tendency towards higher UI/Creat levels as the L-T4 (µg/Kg) dosage increased, although no correlation was found. Newborns of women taking an ICS were found to have elevated neonatal TSH (2.8 mIU/L vs. 1.7 mIU/L) (p = 0.04). All newborns with a TSH >5 mUI/L were those of women taking supplements. Conclusions: Women with AT taking L-T4 still need iodine supplementation, although the amount should be regulated on the basis of their L-T4 dosage.
Comparison of the Acute Effects of Carbohydrate Mouth Rinse and Coach Encouragement on Kinematic Profiles During Small-Sided Games in Young Male Soccer Players
Authors: Birinci Yakup Zühtü , Pancar Serkan , Soylu Yusuf
Published: January 2025

Background: Carbohydrate mouth rinsing (CHOmr), a nutritional intervention for delaying fatigue and meeting the energy demands of soccer, and the motivational strategy of coach encouragement (CE) are widely recognized as effective approaches for enhancing athletic performance in soccer. Objectives: This study aimed to compare the effects of CHOmr + CE, CHOmr, and CE on heart rate (HR) and kinematic profiles during four-a-side small-sided soccer games (SSGs). Methods: Twenty-four young soccer players (age: 17.2 ± 0.8 years) played six bouts of four-a-side SSGs with CHOmr + CE, CHOmr, or CE at 3-day intervals in a randomized, single-blinded, placebo-controlled, or crossover study design. The HR and kinematic responses were continuously recorded during all games. Results: There were no statistically significant differences between the groups in peak heart rate (HRpeak) (p ≥ 0.05, F = 0.326, p = 0.723, η2 = 0.014) and mean heart rate (HRmean) (p ≥ 0.05, F = 0.845, p = 0.436, η2 = 0.035). No significant differences were found for distances in Zone 1 (p ≥ 0.05, F = 1.21, p = 0.306, η2 = 0.050), Zone 4 (p ≥ 0.05, F = 0.310, p = 0.735, η2 = 0.013), Zone 5 (p ≥ 0.05, F = 1.02, p = 0.368, η2 = 0.042), or Zone 6 (p ≥ 0.05, F = 0.161, p = 0.211, η2 = 0.055), nor acceleration (p ≥ 0.05, F = 0.208, p = 0.137, η2 = 0.083) and deceleration (p ≥ 0.05, F = 0.790, p = 0.460, η2 = 0.033). Similarly, although no significant differences were observed in the distance in Zone 3 (p ≥ 0.05, F = 3.12, p = 0.054, η2 = 0.119) or repeated sprint distance (p ≥ 0.05, F = 2.96, p = 0.062, η2 = 0.114), the CHOmr +CE group exhibited higher average values for these variables. However, a statistically significant difference was observed in the distance covered in Zone 2 (p ≤ 0.05, F = 3.89, p = 0.028, η2 = 0.145), with the CHOmr +CE group performing better, as confirmed by the post-hoc analyses. Conclusions: Although our findings indicate that CE alone may influence kinematic profiles during SSGs, similar to CHOmr or its combination with CE, further research should explore the underlying mechanisms and potential contextual factors influencing these outcomes. Therefore, we suggest that coaches prefer CE because it is easy to implement.
Tuning the Optical Properties of Electrospun Poly(methyl methacrylate) Nanofibres via Montmorillonite and Magnetite Ratios
Authors: Tsekpo Yao Mawuena , Smok Weronika , Matus Krzysztof , Hajduk Barbara , Radoń Adrian , Jarka Paweł , Tanski Tomasz
Published: January 2025

Poly(methyl methacrylate) (PMMA) polymer has unlocked new frontiers in the field of nanotechnology and is suitable for a wide range of applications. However, its optical band gap limits its use in optoelectronics. This study aims to ascertain the influence of varying montmorillonite and magnetite ratios on the optical properties of electrospun PMMA nanofibres produced from solution. The nanofibres were characterised using Fourier-transform infrared spectroscopy (FTIR), atomic force microscopy (AFM), scanning electron microscopy (SEM), X-ray diffractometry (XRD), energy-dispersive X-ray spectroscopy (EDX), spectroscopic ellipsometry, and UV-Vis spectroscopy (UV-Vis). XRD analysis revealed the successful incorporation of magnetite and montmorillonite within the PMMA matrix, with diameters ranging from 203 to 328 nm. The incorporation of magnetite and montmorillonite altered the light absorption characteristics of PMMA, resulting in increased absorption in the ultraviolet and visible light regions compared to pristine PMMA and a reduction in the optical band gap from 4.9 eV to 2.5 eV. These findings suggest that PMMA is a suitable host matrix for montmorillonite and magnetite. The observed properties also indicate the suitability of the produced materials for optoelectronic applications, including chemical sensors and protective UV coatings.
A Portable Magnetoelectric Gaussmeter Based on Torque Effect
Authors: Wu Jingen , Qiao Jiacheng , Liang Xianfeng , Du Yongjun , Gao Jieqiang , Xu Yiwei , Guo Jinghong , Lu Min , Zhang Ming , Hu Zhongqiang
Published: January 2025

A giant magnetoelectric coefficient has been discovered in laminated magnetoelectric composites incorporating piezoelectric and magnetostrictive layers, which reveals a high sensitivity in AC magnetic field detection under a DC bias field. However, the DC-biased magnetoelectric composites are not capable of detecting DC magnetic fields due to the interference with the DC signal to be measured. Here, we demonstrate a portable magnetoelectric gaussmeter based on torque effect that can detect both DC and AC magnetic fields. The proposed gaussmeter is equipped with a magnetoelectric sensor, a charge amplification module, a signal processing circuit, a power module, a data processing program, a display module, etc. The proposed gaussmeter indicates such performance indexes as an intensity range of 0~10 Oe, frequency range of DC~500 Hz, AC detection limit of 0.01 Oe, DC detection limit of 0.08 Oe, and frequency resolution of 1 Hz. Being powered by a power adapter (or a battery) of 5V 2A, the whole device system is pocket-size, low-cost, and highly portable, demonstrating its potential for magnetic field detection as a distributed sensor.
Line-YOLO: An Efficient Detection Algorithm for Power Line Angle
Authors: Wang Chuanjiang , Chen Yuqing , Wu Zecong , Liu Baoqi , Tian Hao , Jiang Dongxiao , Sun Xiujuan
Published: January 2025

Aiming at the problem that the workload of human judgment of the power line tilt angle is large and prone to large errors, this paper proposes an improved algorithm Line-YOLO based on YOLOv8s-seg. Firstly, the problem of the variable shape of the power line is solved through the introduction of deformable convolutional DCNv4, and the detection accuracy is improved. The BiFPN structure is also introduced for the Neck layer, which shortens the time required for feature fusion and improves the detection efficiency. After that, the EMA attention mechanism module is added behind the second and third C2f modules of the original model, which improves the model’s ability to recognize the target, and effectively solves the problem of loss and error when power line targets overlap. Finally, a small target detection head is added after the first EMA attention mechanism module for detecting small or occluded targets in the image, which improves the model’s ability to detect small targets. In this paper, we conduct experiments by collecting relevant power line connection images and making our dataset. The experimental results show that the mAP@0.5 of Line-YOLO is improved by 6.2% compared to the benchmark model, the number of parameters is reduced by 28.2%, the floating-point operations per second is enhanced by 35.3%, and the number of detected frames per second is improved by 14 FPS. It is proved by the experiments that the enhanced model Line-YOLO detects the results better, and it can efficiently complete the power line angle detection task.
Acute Painful Transfusion Reactions (APTRs): A Comprehensive Review of Clinical Features, Pathophysiology, Diagnosis, and Management
Authors: Delicou Sophia , Argyrou Aspasia , Mellou Sophia , Xydaki Aikaterini , Gafou Anthippi , Politis Constantina
Published: January 2025

It is important to recognize the significance of acute painful transfusion reactions (APTRs) as a complication of blood transfusions. These adverse reactions are characterized by the onset of acute pain after the administration of blood components. Despite their potential to cause significant discomfort and distress to patients, these reactions are frequently disregarded and under-reported in clinical practice. This review aims to provide a comprehensive analysis of the clinical features, pathophysiology, diagnosis, incidence, and management of APTRs, emphasizing the necessity for heightened awareness and further research in this field.
Characterization and Protective Efficacy of a Salmonella Typhimurium ATCC 14028 sptP Mutant as a Live Attenuated Vaccine Candidate
Authors: Zhou Nanlong , Ding Yonghui , He Ting , Sun Yuling , Chen Hongfang , Huang Meiling , Li Tiansen
Published: January 2025

Background: Salmonella Typhimurium poses a substantial health risk to both humans and animals. This study evaluated the potential of using the Salmonella Typhimurium ΔsptP mutant as a live-attenuated vaccine candidate by constructing it through homologous recombination and assessing its key biological properties, including growth characteristics, immunogenicity, and protective efficacy. Methods: We generated the ΔsptP mutant through targeted gene deletion, ensuring the preservation of the bacterial strain’s growth and stability. In vitro and in vivo assays were performed to compare the invasive capabilities between the mutant and the wild-type strains. Specifically, we examined the invasion into RAW264.7 murine macrophages and mice. Furthermore, the virulence of the mutant was evaluated by determining the median lethal dose (LD50). To evaluate immunogenicity and protection, mice were immunized with 2 × 104 CFUs of the ΔsptP mutant, followed by a booster immunization, and then challenged with a virulent strain. Results: The ΔsptP mutant exhibited no significant changes in growth characteristics or genetic stability compared to the wild-type strain. However, it demonstrated a significantly diminished capacity for invasion in both murine macrophages and mice. The LD50 for the mutant was 39.92-fold higher than that of the wild-type, indicating a marked reduction in virulence. Mice immunized with the ΔsptP mutant and administered a booster immunization exhibited 87.5% protection against challenge with a virulent strain, as compared to the PBS control group. Moreover, the mutant induced IgG antibody levels comparable to those induced by the wild-type strain. Conclusions: The ΔsptP mutant of Salmonella Typhimurium exhibits markedly reduced virulence while retaining robust immunogenicity and protective efficacy. These findings suggest that the ΔsptP mutant is a promising candidate for a live-attenuated vaccine, potentially providing an effective strategy to prevent Salmonella Typhimurium infections.
Investigation of Splashing Characteristics During Spray Impingement Using VOF–DPM Approach
Authors: Chen Mingming , Li Linmin , Lin Zhe , Zhang Junhao , Li Fengyu
Published: January 2025

Liquid jets impinging on surfaces are widely found in various industrial processes, such as spray painting, high-pressure water jets, and dishwashers. The liquid jets can break up into sprays with discrete, small-scale features that are difficult to reveal. This work proposes a multiscale solver in OpenFOAM that achieves two-way conversion by capturing the large-scale interface using the Volume of Fluid (VOF) approach and tracing small-scale droplets using the Discrete Phase Model (DPM). By comparing the VOF–DPM solver with the standard VOF solver, the conservation of mass and momentum, as well as the accuracy of the new solver are verified. Considering that, in spraying processes, collisions mainly occur after the liquid jet breaks up into multiple droplets, we simplify the model to focus on the collision of droplets with walls at different speeds and contact angles, corresponding to different materials. The results indicate that, as the speed increases, splashing becomes more likely and the droplets spurt further. It is also found that an increase of contact angle will increase the mean diameter of the discrete droplets. Overall, this multiscale solver can accurately capture both large-scale interfaces and small-scale droplets, offering wide application prospects.
Eficacia de las ondas de choque extracorpóreas en pacientes con síndrome del túnel carpiano. Revisión sistemática de la literatura
Authors: Sánchez-Lozano Jesús , Martínez-Pizarro Sandra
Published: January 2025

Introducción: el síndrome del túnel carpiano es la neuropatía por atrapamiento más común de la extremidad superior. Se caracteriza por dolor en la mano, entumecimiento y hormigueo en la distribución del nervio mediano. Con el tratamiento estándar no siempre se consiguen buenos resultados por ello, recientemente se ha propuesto como tratamiento innovador el uso de las ondas de choque extracorpóreas en estos pacientes. Funcionan mediante la emisión de ondas acústicas que transportan energía y pueden propagarse a través de los tejidos.  Objetivo: realizar una revisión sistemática sobre la eficacia de las ondas de choque extracorpóreas en pacientes con síndrome del túnel carpiano.  Métodos: se seleccionaron ensayos clínicos aleatorizados controlados, realizados en humanos, llevados a cabo en los últimos diez años. La principal base de datos usada ha sido PubMed, a través de la plataforma National Library of Medicine.  Resultados:  la muestra total fue de 247 pacientes de seis estudios, las ondas de choque extracorpóreas son eficaces en pacientes con síndrome del túnel carpiano. La frecuencia de administración fue de una vez por semana durante tres semanas. La aplicación del tratamiento fue segura y no se produjeron efectos adversos graves. Se trata de un tratamiento no invasivo útil a corto plazo y que, comparado con la ecografía, la crioecografía y las inyecciones locales de corticoesteroides es más eficaz.  Conclusiones: las ondas de choque extracorpóreas mejoran el dolor, la funcionalidad, la conducción nerviosa y la latencia sensorial distal del nervio mediano en pacientes con síndrome del túnel carpiano.
Efecto de un programa de ejercicio aeróbico más fuerza muscular de Rehabilitación Cardiovascular Fase II, sobre la resistencia aeróbica y la fuerza muscular de adultos mayores con enfermedad cardiovascular
Authors: Heyden-López Franklin
Published: January 2025

Introducción: las enfermedades cardiovasculares presentan la primera causa de muerte a nivel mundial y nacional. La rehabilitación cardiovascular es un proceso terapéutico que reduce síntomas, morbi-mortalidad, mejora la capacidad funcional, la calidad de vida y el bienestar psicológico de las personas con Enfermedad cardiovascular. Los programas de rehabilitación cardiovascular tradicionalmente incluyen la educación sanitaria enfocado en el control de factores de riesgo cardiovasculares, el entrenamiento físico, con trabajo aeróbico más la intervención psicosocial, sin incluir el componente de fuerza. Objetivo: determinar el efecto de un programa de ejercicio aeróbico más fuerza muscular de Rehabilitación Cardiovascular Fase II, sobre la resistencia aeróbica y la fuerza muscular de adultos mayores con enfermedad cardiovascular Metodología: estudio observacional descriptivo, retrospectivo. Se tomaron los resultados pre y post de 199 adultos mayores que participaron del Programa de Rehabilitación Cardiovascular Fase II del Hospital Nacional de Geriatría y Gerontología, entre 2014 y 2019, se revisaron datos de resistencia aeróbica y fuerza muscular de adultos mayores con enfermedad cardiovascular. El programa consistió en dos grupos que realizaron 24 y 32 sesiones de trabajo que incluyó, entrenamiento aeróbico y fuerza muscular. Se realizó análisis de varianza ANOVA mixta para cada variable, los resultados se expresan como promedio ± desviación estándar, nivel de significancia establecido en p≤0,05. Resultados:  se identificaron diferencias estadísticamente significativas en la Resistencia aeróbica [Caminata seis minutos (Distancia recorrida mejoró con magnitud de cambio de 45,8 m, p<0,001; el consumo de oxígeno (VO2) mejoró con magnitud de cambio de 1 ml/kg/min, p<0,001; el equivalente metabólico (METs) logrado mejoró con magnitud de cambio de 0,21, p<0,001). Prueba de esfuerzo (METs alcanzado mejoró con magnitud de cambio de 2,26, p<0,001; VO2 mejoró con magnitud de cambio de 5,49 ml/kg/min, p<0,001)]; así como en la fuerza muscular (repeticiones miembros inferiores mejoró con magnitud de cambio de 2,46 repeticiones, p<0,001; repeticiones  miembros superiores mejoró con magnitud de cambio de 3,24 repeticiones, p<0,001; percentil miembros inferiores mejoró con magnitud de cambio de 18,88%, p<0,001; percentil miembros superiores mejoró con magnitud de cambio de 21,48%, p<0,001). Conclusión: un programa de ejercicio combinado de rehabilitación cardiovascular fase II podría mejorar la resistencia aeróbica, así como la fuerza muscular de adultos mayores con enfermedad cardiovascular.
Enseñanza de la medicina bajo el modelo del currículo integrado: la importancia de las tendencias educativas contemporáneas
Authors: Zeledón-Sánchez Fernando
Published: January 2025

El currículo integrado en medicina se implementó por primera vez hace más de 72 años. Su abordaje es muy distinto al currículo “flexneriano”, el cual divide la medicina en ciencias básicas y clínicas, con una gran muralla entre estas dos grandes áreas. A la vez, la investigación educativa respalda el cambio hacia modelos de enseñanza en donde se propicie el aprendizaje activo de los estudiantes de medicina, y desarrollen competencias que normalmente los currículos tradicionales no fomentan enérgicamente (competencias en comunicación, interpersonales, organizacionales y gestión, personales, tecnológicas, procedimentales y cognitivas) desde el inicio de su formación. Aun así, a pesar de que el currículo integrado ha mostrado avances importantes en la educación médica, su implementación es difícil y a la fecha, al menos en nuestro país, ninguna escuela de medicina presenta un abordaje totalmente integrado. Esta revisión narrativa hace un recorrido histórico del currículo integrado y a la vez, recalca como sus aspectos pedagógicos van de la mano con nuevas tendencias educativas de aprendizaje activo.
Aporte del profesional en terapia respiratoria en la atención de las principales enfermedades respiratorias en el primer nivel de atención de salud en Costa Rica
Authors: Moya Brenes Elena , Ordóñez Wong Ana Lucía , Sánchez-Guevara Kristy , Calvo-Gómez Sharon
Published: January 2025

Objetivo: establecer el aporte del profesional en terapia respiratoria en la aplicación de estrategias para la atención de las principales enfermedades respiratorias en el primer nivel de atención de salud en Costa Rica. Metodología: se realizó revisión sistemática narrativa sobre enfermedades respiratorias en el primer nivel de atención, y la intervención del terapeuta respiratorio en estas patologías. Los motores de búsqueda incluyen Google Académico, SciELO, EBSCO host y Redalyc, con una temporalidad del 2013 al 2023, en inglés y español. Se usaron como descriptores: “Enfermedades respiratorias”, “Estrategias de atención”, “Primer nivel”, “intervenciones”, “Atención para enfermedades respiratorias” y “terapia respiratoria”. Se incluyeron 31 artículos científicos que fueron clasificados según el nivel de evidencia de Sackett, de la siguiente manera: uno (3,2%) nivel I, dos (6,4%) nivel II, uno (3,2%) nivel III, doce (38,7%) nivel IV y quince (48,4%) nivel V. Resultados: las estrategias de abordaje de enfermedades respiratorias como el asma, enfermedad pulmonar obstructiva crónica, bronquiolitis, y neumonía se basan en lineamientos para estandarizar acciones en el primer nivel de atención con programas de educación, uso de dispositivos, inhaloterapia y broncodilatadores. Brindando una respuesta coordinada y efectiva para estas enfermedades. Conclusiones: la terapia respiratoria juega un papel fundamental en el manejo integral de enfermedades respiratorias. Aunque la estrategia atención para enfermedades respiratorias establece las bases para intervenciones terapéuticas, no considera al profesional en terapia respiratoria en el primer nivel, evidenciando oportunidades para una participación más integral y específica de estas patologías
La horticultura como herramienta de intervención en terapia ocupacional: experiencia con personas en situación de discapacidad de la comuna de Huechuraba, un estudio de caso en Chile
Authors: Medina-Cabrera Paula , Rueda-Castro Laura
Published: January 2025

Introducción: la Horticultura Terapéutica (HT) es una práctica basada en la naturaleza, la cual es utilizada como herramienta interventiva de Terapia Ocupacional (TO), esta se caracteriza por facilitar el desarrollo de habilidades en las diferentes áreas del desempeño ocupacional. Si bien, existe evidencia en diferentes contextos y poblaciones, en personas en situación de discapacidad (PsD) es mínima. Por lo que el objetivo de este estudio fue analizar las prácticas interventivas de HT con PsD en el Centro Ocupacional Hortiterapeutico (COH) de la comuna de Huechuraba (Región Metropolitana, Santiago de Chile) considerando su larga trayectoria en la rehabilitación y apoyar el proceso de inclusión sociolaboral. Además de relevar el rol socioecológico de la TO, en la promoción de prácticas sustentables, para hacer frente a la crisis climática. Métodos: se realizó una aproximación cualitativa, a través de un estudio de caso con aspectos del diseño narrativo, desde un paradigma constructivista y la epistemología de la T.O Eco Social. La recolección de datos fue mediante entrevistas en profundidad y observaciones participantes. Resultados: los principales hallazgos, refieren la eficacia de la H.T en el desarrollo de habilidades sociales, motoras y cognitivas, el aumento de la participación sociolaboral y sentido de pertenencia. Destacando la historicidad e innovación del COH, al implementar la H.T desde fundamentos comunitarios, ecológicos y ocupacionales. Conclusión:  se destaca la importancia de seguir profundizando el uso de la H.T en PsD, para aumentar la línea investigativa, de esta forma promover la construcción de comunidades ecológicas e inclusivas.
Utilidad de la electrococleografía en el protocolo de evaluación de pacientes con desorden del espectro de neuropatía auditiva para implante coclear
Authors: Calderón-Arias Marcela , Alfaro-Cartín Hellen , Jiménez-Coto Gabriela
Published: January 2025

Introducción: las personas con desorden del espectro de neuropatía auditiva tienen problemas en el procesamiento del sonido y la comprensión del lenguaje, por tener una o varias estructuras de la vía auditiva afectadas. Se ha planteado como opción de rehabilitación el implante coclear. La electrococleografía aplicada en pacientes con desorden del espectro de neuropatía auditiva permite realizar un topo-diagnóstico de la lesión, para obtener expectativas más confiables del desempeño auditivo de un paciente candidato a implante coclear con esta patología. El objetivo de esta revisión es evidenciar la utilidad de la electrococleografía en el protocolo de evaluación de pacientes con desorden del espectro de neuropatía auditiva para implante coclear. Metodología: estudio de revisión bibliográfica sistematizada de tipo cualitativo con evidencia científica encontrada en las bases de datos EBSCO, Scielo, PubMed y Medline, utilizando como descriptores las palabras electrococleografía AND desorden del espectro de neuropatía auditiva OR neuropatía auditiva, electrocochleography AND auditory neuropathy spectrum disorder OR auditory neurpathy, electrococleografía AND implante coclear, electrocochleography AND cochlear implant, implante coclear AND desorden del espectro de neuropatía auditiva OR neuropatía auditiva, cochlear implant AND auditory neuropathy spectrum disorder OR auditory neuropathy. Se seleccionaron artículos publicados del 2012 al 2024, en idiomas español, inglés y portugués, para un total de 21 referencias bibliográficas. Resultados: la rehabilitación auditiva en personas con desorden del espectro de neuropatía auditiva ha sido un tema en discusión; mientras que unos apoyan la idea del implante coclear, otros no. La electrococleografía nos brinda la oportunidad de estudiar el sitio de la lesión, y nos brinda un pronóstico más realista en cuanto a abordaje, rendimiento y expectativas del tratamiento mediante implante coclear. Conclusiones: la aplicación de la electrococleografía en pacientes candidatos a implante coclear diagnosticados con desorden del espectro de neuropatía auditiva, tiene un gran aporte en cuanto al topo-diagnóstico, para el debido manejo de expectativas, en cuanto a los resultados del implante.
Influencia de la magnetoterapia en la regeneración ósea: un reporte de caso
Authors: Mena-Castro Juan Pablo , Sánchez-Campos Sara
Published: January 2025

La magnetoterapia, que utiliza campos magnéticos para inducir campos eléctricos en los tejidos tratados, ha demostrado ser eficaz en la recuperación de fracturas por avulsión. Esta terapia favorece la formación de osteoblastos y la regeneración ósea. Es especialmente útil en áreas donde los tejidos blandos se insertan en el hueso, como tendones y ligamentos, la magnetoterapia ha ganado respaldo en fisioterapia y ortopedia. El reporte de caso que se expone a continuación es de una paciente de 33 años que sufrió una fractura por avulsión del vértice del maleolo externo del tobillo izquierdo, quien recibió atención domiciliar por indicaciones de abordaje fisioterapéutico con 36 sesiones de terapia física que incluyó dosis de magnetoterapia, de agentes electro físicos, de terapia manual y ejercicio terapéutico, mejorando en un 100% la remodelación ósea y la recuperación funcional de su articulación tibio-peronea-astragalina izquierda. La magnetoterapia se presenta como una herramienta prometedora para tratar fracturas por medio de los campos magnéticos pulsados que estimulan la actividad celular, promueven la deposición de calcio y mejoran la vascularización local, facilitando la consolidación ósea. Una evaluación correcta y uso del razonamiento clínico en la toma de decisiones terapéuticas lleva a una dosificación correcta de estos medios de tratamiento.
Two approaches to interpreting culture
Authors:   M.K. Ammosov North-Eastern Federal University, Koriakina A. A.
Published: January 2025

The article examines the key concepts of culture through various interpretations of the notion of “culture”. According to one of them, culture is considered as an integral part of the social system, or as a conceptually separate, sociocultural ideological system. According to another concept, it is considered as an ideational system, or as a system of ideas, through cognitive, structuralist and semiotic approaches.
THE FIGURE OF NELLIA NYCHKALO IN THE DIMENSIONS OF LABOUR PEDAGOGY
Authors: Vovk M. , Semenog O.
Published: January 2025

The article outlines the conceptual directions of the professional activity of Academician Nellia Hryhorivna Nychkalo in the dimensions of labor pedagogy. Based on biographical information and facts from the academician's biography, it is proven that her initiatives testify to an effective professional and life position, a focus on the implementation of conceptual ideas of labor pedagogy in the scientific and educational space to affirm the values of science and education, strengthen international educational partnership, taking into account the realities of war, the need to realize the value of science, culture, and education as the main factors of preserving national identity. Nellia Hryhorivna Nychkalo's  moral dignity and inner need not to stand aside from significant socio-cultural shifts in the conditions of Russia's war against Ukraine determined her optimistic and productive work to strengthen partnerships between educational institutions and scientific institutions of Ukraine and abroad, systematic coverage of the results of the activities of the institutes of the National Academy of Sciences of Ukraine, which is aimed at affirming national and European values of education and science, etc. Work as a life concept of Academician N.H. Nychkalo became a reference point in the implementation of the research, educational, and educational mission from the beginning of the full-scale invasion of the Russian Federation into the territory of Ukraine. Nellia Hryhorivna sees her professional mission as highlighting the significant experience of strengthening the national foundations of Ukrainian education, confronting the opposition of Russian ideology, as evidenced by the publication initiated by her in collaboration with a group of co-authors, “Ukrainian Education in the Flames of War” (monograph / author N. Nychkalo, O. Ovcharuk, V. Hordiienko, I. Ivaniuk; edited by N. Nychkalo. Kyiv: LLC “Yurka Liubchenko”, 2024. 208 p.). The development of international partnerships in the scientific and educational space is facilitated by holding the 10th Ukrainian-Polish / Polish-Ukrainian Scientific Forum “Education for the Digital Transformation of Society” (November 27-28, 2024) at the initiative of Academician N.H. Nychkalo.
THE PLACE OF RELIGION IN THE MODERN PEDAGOGICAL PROCESS
Authors: Soroka V. , Fazan Vit. , Fazan V. , Fazan T.
Published: January 2025

The article considers the issues of the relationship between religion and school education that are relevant to Ukraine. Today, the issues of regulation have been resolved at the legislative level, but problems with their implementation at the practical level remain. In particular, subjects of a spiritual and moral direction have been introduced, but their provision does not take into account world developments in methodology. The models of interaction between religion and education adopted in the world can be divided into three main groups, each of which focuses on individual important aspects of such interaction. For Ukraine today, it is necessary not only to ensure the possibility of introducing a religious component into the general education system but also to clearly define its place and tasks, for which it is necessary to take into account both theoretical and methodological developments and practical ways of resolving controversial situations.
Education of the individual has always been the most important problem in any state. In modern conditions, it is especially relevant: the rapid development of science, technology, and rapid reforms in the social and political spheres require a person to be highly professional, to have stable personal traits, in particular moral and volitional qualities (responsibility, civic position, independence, resilience and generosity, etc.). In this regard, it is important not only to build original models of education, to ensure the implementation of existing concepts of education, but also to appeal to the domestic theoretical and practical educational experience accumulated in the past. The issue of spiritual and moral education of the individual on the basis of Christian values is relevant for parents and teachers, as well as society, because in the process of assimilating Christian moral values, children learn goodness, mercy, and compassion.
EXPERIENCE OF IMPLEMENTING INNOVATIVE ENGLISH LANGUAGE TEACHING METHODS IN A REGIONAL HIGHER EDUCATIONAL INSTITUTION IN WAR CONDITIONS
Authors: Marchuk Yu.
Published: January 2025

The article reviews innovative technologies that are being implemented in practice in a higher educational institution located in a territory close to military actions. The administration's actions to increase the efficiency of various forms of the educational process in wartime have been highlighted. At the same time, it has been emphasized that there is a need for education reform, because in order for Ukrainian higher education institutions to be competitive, they must focus on improving the quality of educational services and increasing demand among Ukrainian youth. The quality of content of educational programs and the active involvement of innovative technologies in the educational process herewith should play a major role.
It has been emphasized that the ability of an English teacher to use innovative methodology in the educational process not only has a significant impact on the speech and intellectual development of the students themselves, but also increases their intercultural communication skills, determines the further competitiveness of young people in the global labour market, lays the foundation for high-quality professional growth, significantly develops the professional competencies of the teachers themselves and improves the quality of teaching through the use of active methods and innovative forms of learning, control and assessment.
The main directions of innovations in modern education have been outlined. New teaching technologies which a modern higher education teacher implements using innovative teaching methods have been described. The implementation of such innovative teaching methods into the process of teaching English as personal approach, practice-oriented learning, simulation learning technologies, flipped learning, STEM education, etc. has been disclosed.
Perfil dos pacientes vítimas de AVC isquêmico trombolisados após implantação da linha do cuidado: estudo retrospectivo
Authors: De Sousa Diêgo Afonso Cardoso Macêdo , Soares Lorena Sousa , Silva-Néto Raimundo Pereira da , Costa Carlos Alberto Teixeira , Machado Mauro Mendes Pinheiro
Published: January 2025

Introdução. O Acidente Vascular Cerebral (AVC) transita como a segunda principal causa de morte dos brasileiros há anos, sendo o isquêmico, como o principal. Nesse contexto, em 2012, foi criada a Linha de Cuidados em AVC, que deu mais atenção, organização e viabilidade financeira para prevenir, tratar e reabilitar pacientes vítimas de AVC. Objetivo. Descrever o perfil dos pacientes vítimas de AVC isquêmico (AVCi) trombolisados após implantação da linha do cuidado. Método.  Tratou-se de um estudo exploratório, retrospectivo, do tipo descritivo, com abordagem quantitativa. Foram estudados os prontuários dos pacientes com AVCi submetidos a trombólise no período de 2022 a 2023. Resultados. Foram avaliados 12 prontuários. A amostra foi constituída majoritariamente por mulheres (n=8, 66%), com idade média de 66 anos, de cor parda (n=11, 92%) e residentes em Parnaíba-PI (n=8, 66%). O tempo de início dos sintomas à admissão no serviço foi de 01h38min e o tempo médio para realização da tomografia de crânio após admissão hospitalar foi de 32min. Clinicamente, 75% dos pacientes conviviam com Hipertensão Arterial Sistêmica e a pontuação média da National Institute of Health Stroke Scale (NIHSS) foi de 15 pontos. Todos os pacientes utilizaram alteplase como droga para tratamento, sendo que 3 (25%) tiveram AVC hemorrágico ou rebaixamento do nível de consciência (RNC) como possível reação adversa a medicamento, evoluindo ao óbito. Conclusão. A amostra corrobora com a maioria dos estudos e mudou a realidade local, todavia é necessário a necessidade de manutenção da educação permanente e adequação dos registros em prontuário.
La mission d’étude sur la trichinose en Allemagne en 1866 de Jean Reynal, un ancien président de la société de médecine vétérinaire
Authors: Dupouy-Camet Jean
Published: January 2025

Cet article reconstitue une mission effectuée en 1866 par le vétérinaire Jean Reynal en Allemagne. Il était accompagné du médecin Auguste Delpech. Tous les deux étaient membres de l’Académie impériale de médecine. L’objectif de cette mission était de mieux connaitre la trichinose, une maladie nouvellement identifiée, liée à la consommation de viande de porc et sévissant en Allemagne. Lors de cette mission de plusieurs semaines, ils rencontrèrent les sommités médicales du temps en Allemagne (Virchow, Gerlach, Fiedler, Müller, Wagner…) et ils se forgèrent une opinion sur la maladie et sa prévention. Selon eux, la crainte d’épidémies de trichinose en France n’était pas justifiée car les Français cuisent plus la viande de porc que les Allemands. Ils ne recommandaient donc pas « une inspection générale et obligatoire des viandes de porc par le microscope » mais ils suggéraient « d'établir des relevés statistiques » de la prévalence de la parasitose chez les porcs et « de répandre par des circulaires dans les populations agricoles la connaissance des précautions à prendre pour les en garantir ».