bluuebunny/crossref_metadata_2025 huggingface dataset:
Nuclear translocation of p85β promotes tumorigenesis of PIK3CA helical domain mutant cancer
Authors: Hao Yujun , He Baoyu , Wu Liping , Li Yamu , Wang Chao , Wang Ting , Sun Longci , Zhang Yanhua , Zhan Yangyang , Zhao Yiqing , Markowitz Sanford , Veigl Martina , Conlon Ronald , Wang Zhenghe
Published: May 2021

PI3Ks consist of p110 catalytic subunits and p85 regulatory subunits. PIK3CA, encoding p110, is frequently mutated in human cancers. Most PIK3CA mutations are clustered in the helical domain or the kinase domain. Here, we report that p85 disassociates from p110α helical domain mutant protein and translocates into the nucleus through a nuclear localization sequence (NLS). Nuclear p85β recruits deubiquitinase USP7 to stabilize EZH1 and EZH2 and enhances H3K27 trimethylation. Knockout of p85β or p85β NLS mutant reduces the growth of tumors harboring a PIK3CA helical domain mutation. Our studies illuminate a novel mechanism by which PIK3CA helical domain mutations exert their oncogenic function. Finally, a combination of Alpelisib, a p110α-specific inhibitor, and an EZH inhibitor, Tazemetostat, induces regression of xenograft tumors harboring a PIK3CA helical domain mutation, but not tumors with either a WT PIK3CA or a PIK3CA kinase domain mutation, suggesting that the drug combination could be an effective therapeutic approach for PIK3CA helical domain mutant tumors.
The Clinical Prediction Factors of Non Chronic Total Occlusion Lesions Progression in Patients Underwent Percutaneous Coronary Intervention for Chronic Total Occlusion Lesions
Authors: wang jian , He Song-yuan
Published: May 2021

Backgroud :To investigate the clinical prediction factors of non chronic total occlusion lesions progression in patients underwent percutaneous coronary intervention(PCI) for chronic total occlusion lesions.Methods: A total of 450 unstable angina patients (57.1 ± 9.2 years) underwent PCI from January 2016 to December 2018 in Beijing Anzhen Hospital were enrolled in this study. All patients underwent PCI as treatment for chronic total occlusion lesions. Clinical and angiographic follow-up were performed in 12 months. All patients were divided into non chronic total occlusion lesions(NCTOL) progression group (205 cases) and the control group (275 cases) according to angiographic follow-up outcome in 12 months. The clinical and angiographic features were analyzed.Results: levels of adenosine diphosphate (ADP) induced platelet aggregation rate(ADP-IPA) (51.89 ± 14.81 vs 39.63 ± 17.12，P <0.01), lipoprotein(a)(Lp(a))(0.22 ± 0.26 vs 0.14 ± 0.18,P < 0.05) in NCTOL progression group were significantly higher than those in the control group. Logistic regression showed that ADP induced PAR (odds ratio =1.047, 95% confidence interval:1.014-1.082, P = 0.005), Lp(a) (odds ratio =11.972, 95% confidence interval: 1.230 -116.570, P = 0.033) were independent predictors of NCTOL progression. Partial correlation analysis showed that ADP-IPA was positively correlated with NCTOL progression( r = 0. 351,P < 0. 001) .Receiver operating characteristic(ROC) curve showed that the boundary point of ADP-IPA to predict NCTOL progression was 30%, the sensitivity was 86.2% and the specificity was 68.9%.Conclusions: ADP-IPA may be an valuable predictor for NCTOL progression .in unstable angina patients underwent percutaneous coronary intervention(PCI) for chronic total occlusion lesions.
The Expression of Netrin-1 in the Osteoarthritic Temporomandibular Joint
Authors: Xiao Mian , Hu Zhihui , Jiang Henghua , Li Cheng , Guo Huilin , Fang Wei , Long Xing
Published: May 2021

Subchondral bone degeneration is the main pathological change during temporomandibular joint (TMJ) osteoarthritis (OA) development. Netrin-1, an axon-guiding factor, might play roles in OA development and pain. The purpose of this study was to investigate the expression of Netrin-1 in TMJ OA and its possible role in the progression of TMJ OA and pain. The content of Netrin-1 in the synovial fluid of temporomandibular joint disorders (TMDs) patients was detected by ELISA. After injection of MIA into the TMJ animal model, hematoxylin & eosin (H&E) staining, toluidine blue (TB) staining and micro-CT were performed to detect the change of TMJ. Netrin-1 expression in the condyle was detected by immunohistochemical (IHC) staining. The pain experience was examined by the von Frey test in animal model. The concentration of Netrin-1 increased in the synovial fluid of TMJ OA patients with the VAS scores increased. In the TMJ OA model, the structural disorder of subchondral bone was the most obvious at the 2nd week. In addition, the head withdrawal threshold (HWT) was significantly decreased in the TMJ OA model. Netrin-1 expression increased in the subchondral bone at the 2nd week after MIA injection in the mouse TMJ. Cultivate raw264.7 cells and induce them to differentiate into osteoclasts. Netrin-1 and its receptor Unc5B are detected to be expressed on the osteoclast membrane. Thus, Netrin-1 might be a regulator during degeneration and pain in the process of TMJ OA.
Job Performance of Medical Graduates with Compulsory Services in Underserved Rural Areas in China: A Cohort Study
Authors: Li Mingyue , Wang Ziyue , Zhang Baisong , Wei Tiantian , Hu Dan , Liu Xiaoyun
Published: May 2021

Objective China started a national program in 2010 to train qualified general practitioners with compulsory services in rural and remote areas. While this compulsory services program (CSP) has shown positive effects on staffing primary health care in rural areas, very little is known about how well they perform in the rural service. This study aims to evaluate the job performance of those medical graduates from this program and how the program design has influenced their job performance. Methods A cohort study was conducted with medical graduates from CSP and non-CSP (NCSP) in four medical universities in central and western China. Baseline survey and three waves of follow-up surveys were conducted from 2015-2020. The pass rate of China National Medical Licensing Examinations (NMLE) and self-reported job performance were used as measurements of job performance. Comparisons were made between CSP and NCSP graduates. Multivariable regressions were used to identify factors affecting job performance. Results 2154 medical graduates were included in the sample, with 1586 CSP graduates and 568 NCSP graduates. CSP (90.6%) and NCSP (87.5%) graduates showed no difference in passing the NMLE (P=0.153). CSP graduates reported high job performance, similar to those NCSP graduates (CSP, 63.7; NCSP, 64.2). In the design of CSP, having officially budget posts improved job performance of CSP (β coefficient=4.87, P＜0.05). Working in hometown was also a significant factor that increase job performance when controlling the differences in contracting strategy (β coefficient=1.48, P＜0.05). Conclusion Medical students trained by CSP have demonstrated good job performance in primary healthcare systems in China. Compared to NCSP peers who work in urban areas in majority, CSP graduates’ high job performance could increase the accessibility of equal- or high-quality services in rural areas, which contributes to qualified workforce supply and health equity. Providing officially budgeted posts and working in hometowns can affect job performance and future retention. Early career support can have critical importance for CSP graduates.
Exploring Electroencephalography with the Aid of Quantum Mechanics
Authors: Popiel Nicholas J. M. , Metrow Colin , Laforge Geoffrey , Owen Adrian M. , Stojanoski Bobby , Soddu Andrea
Published: May 2021

An outstanding issue in cognitive neuroscience concerns how the brain is organized across different conditions. For instance, during the resting-state condition, the brain can be clustered into reliable and reproducible networks (e.g., sensory, default, executive networks). Interestingly, the same networks emerge during active conditions in response to various tasks. If similar patterns of neural activity have been found across diverse conditions, and therefore, different underlying processes and experiences of the environment, is the brain organized by a fundamental organizational principle? To test this, we applied principles of quantum mechanisms to model electroencephalogram (EEG) data. We uncovered a tendency for EEG signals to be localized in anterior regions of the brain during “rest”, and more uniformly distributed while engaged in a task (i.e., watching a movie). Moreover, we found analogous values to the Heisenberg uncertainty principle, suggesting a common underlying architecture of human brain activity in resting and task conditions. This underlying architecture manifests itself in the novel constant KBrain, which is extracted from the brain state with the least uncertainty. We would like to state that we are using the mathematics of quantum mechanics, but not claiming that the brain behaves as a quantum object.
Cadmium-induced Oxidative Stress in Meretrix Meretrix Gills Leads to Mitochondria-mediated Apoptosis
Authors: Wang Jinhua , Deng Wanfei , Zhou Ting , Bai Binbin , Chang Alan K. , Ying Xueping
Published: May 2021

Cadmium (Cd) is one of the most important marine environmental pollutants that can cause oxidative damage and apoptosis in living organisms, and mitochondria are the key target cell organelles of Cd toxicity. In this study, we investigated the effect of Cd on the mitochondria of Meretrix meretrix gill cells and the underlying mechanism of mitochondria-mediated apoptosis following exposure to the metal. Exposure of the clams to 1.5, 3, 6 and 12 mg L−1 Cd2+ solutions led to swollen mitochondria compared with the untreated clams. The mitochondria also became vacuolated at the higher Cd2+ concentrations. Biochemical assays showed that monoamine oxidase (MAO) activity and mitochondrial membrane potential (Δψm) increased at 1.5 mg L−1 Cd2+, but decreased at higher Cd2+ concentrations, while the activities of malate dehydrogenase (MDH) and cytochrome oxidase (CCO) and the scavenging capacities of anti-superoxide anion (ASA) and anti-hydroxy radical (AHR) all decreased with increasing Cd2+ concentrations. Significant increases in the levels of MDA and H2O2 as well as in the activity levels of caspase-3, -8, and -9 were also observed in the Cd2+-treated clams. The results implied that Cd might induce apoptosis in M. meretrix via the mitochondrial caspase-dependent pathway.
Early Knee Osteoarthritis Classification and Clinical Evolution: a Longitudinal Observational Study.
Authors: Alabajos-Cea Ana , Herrero-Manley Luz , Suso-Martí Luis , Pérez-Barquero Juan Alonso , Viosca-Herrero Enrique
Published: May 2021

Objective: The main objective was to determine the relevance of the diagnosis of early osteoarthritis (EOA) according to the existing criteria. The secondary objective was to evaluate the clinical progression of healthy subjects (HS) at risk for osteoarthritis and with EOA. Methods: A cross-sectional longitudinal study was performed. 105 participants were classified through difference diagnosis criteria as EOA patients or HS. Measures of disability, pain and disability self-reported variables were assessed. Two follow-ups were performed, reclassifying all the participants to assess their diagnosis and radiological progression, and evaluating the clinical progression by the self-reported measures.Results: Following the current diagnostic criteria the participants were divided as EOA (n=54) and HS (n=51). Most of the participants did not present changes in their classification, although some subjects were reclassified as EOA or HS in the follow-ups performed. In relation to clinical progression, the ANOVA did not reveal statistically significant differences in time for pain, disability, or psychological variables neither in the HS nor in the EOA.Conclusion: Current classification criteria for EOA based on self-reported measures could, make it difficult to clearly diagnose of EOA leading to changes in the classification of patients according to their condition at each particular moment.
coreSCD: Multi-Stakeholder Consensus on Core Outcomes for Sickle Cell Disease Clinical Trials
Authors: Tambor Ellen , Robinson Matoya , Hsu Lewis , Chang Hsing-Yuan , Naber Jennifer Al
Published: May 2021

BackgroundWith the dramatic increase in the pipeline for new sickle cell disease (SCD) therapies in recent years, the time is ripe to ensure a robust body of evidence is available for decision making by regulators, payers, clinicians, and patients. Harmonization of the outcomes selected across interventional trials enables optimal post-trial appraisal and decision making through valid pooled analyses and indirect comparisons. We employed a structured, multi-stakeholder consensus process to develop core outcome sets (COS) for use in clinical trials of SCD interventions.MethodsCoreSCD utilized a modified Delphi method adapted from the standards recommended by the Core Outcome Measures in Effectiveness Trials (COMET) Initiative. An initial list of candidate outcomes was developed through a targeted literature review and input from an 11-member advisory committee. A 44-member multi-stakeholder Delphi Panel was established and included patients and family members, advocates, clinicians, researchers, payers, health technology assessors, representatives from government agencies, and industry representatives. Patients/advocates comprised 25% of the Delphi Panel and orientation and training was provided prior to the consensus process to ensure all were prepared to participate meaningfully. Panelists completed three rounds of an online survey to rate the importance of candidate outcomes for inclusion in the COS. Summary data was provided between each voting round and an in-person consensus meeting was held between the second and third round of voting. Consensus rules were applied following each round of voting to eliminate outcomes that did not meet predetermined criteria for retention.ResultsConsensus was reached for two core outcome sets. The final COS for trials of disease-modifying therapies includes ten outcomes and the COS for trials of acute interventions includes six outcomes. Both core sets include clinical outcomes as well as outcomes related to functioning/quality of life, resource utilization, and survival/mortality.ConclusionsUse of the COS in clinical development programs for SCD will help to ensure that relevant, consistent outcomes are available for decision making across the product lifecycle.
Effect of Fly Ash on Setting Mechanism and Strength of Commercial Cement: A Chemical Approach
Authors: Bhuvana G. L. , Sherikar B. N. , Honnavar G.V. , Madhusudhana R. , Sahoo Balaram
Published: May 2021

The chemistry and mechanism of mechanical strength-development at different setting-times in different weight-ratios of proclaimed commercial-cement and fly-ash mixture is studied. The main content of fly-ash is the quartz (SiO2). According to our results, as the setting time increases, the quartz present in fly-ash gets utilized during setting of the cement to form the well known C-S-H gel (3CaO.2SiO2.3H2O). Our analysis suggests that the addition of fly-ash reduces the water requirement for the hydration-process. Furthermore, the fly-ash inhibits the formation of CaCO3 phase from portlandite (Ca(OH)2) through atmospheric CO2, and more importantly, it promotes the transformation of portlandite to form the C-S-H network which provides strength and long term stability to the set cement. As the commercial cement already contains optimum amount of fly-ash, any further addition of fly ash leaves the fly-ash partially unreacted which drastically decreases the compressive strength.
Influence of Al2O3 Content on Mechanical Properties of Silica-based Ceramic Cores Prepared by Stereolithography
Authors: Zheng Wen , Wu Jia-Min , Chen Shuang , Wang Chang-shun , Liu Chun-Lei , Hua Shuai-Bin , Yu Kang-Bo , Zhang Jie , Zhang Jing-Xian , Shi Yu-Sheng
Published: May 2021

Silica ceramic cores have played an important role in the manufacture of hollow blades due to its excellent chemical stability and moderate high-temperature mechanical properties. In this study, silica-based ceramics were prepared by stereolithography and the influence of Al2O3 content on mechanical properties of the silica-based ceramics was investigated. With the increase of Al2O3 content, the linear shrinkage of the silica-based ceramics first decreased and then increased, while the room-temperature flexural strength and the high-temperature flexural strength first increased and then decreased. As the Al2O3 content increased to 1.0 vol.%, the linear shrinkage was reduced to 1.64% because of the blocked viscous flow. Meanwhile, the room-temperature flexural strength and the high-temperature flexural strength were respectively improved to 20.38 MPa and 21.43 MPa with 1.0 vol.% Al2O3 due to the increased α-cristobalite and β-cristobalite content. Therefore, using the optimal content of Al2O3 in silica-based ceramics can provide excellent mechanical properties and ensure the reliability of silica-based ceramic cores for manufacturing hollow blades.
Synthesis of Bismuth Doped Yttria Stabilized Zirconia Electrolyte and Study of Ionic Conductivity
Authors: Guo Xia , Zhao Xiaobing , Liu Jinrong , He Weiyan
Published: May 2021

x%molBi3+-doped yttria-stabilized zirconia with 4%molYO1.5 (x = 0–5,BiYSZ) are prepared via lamellar liquid crystal template method.The influence of different doping amount of Bi3+ on crystal form,morphology,the ionic conductivity are investigated in detail.In addition,densification time of BiYSZ are determined.X-ray diffraction(XRD),Raman spectrum,Scanning Electron Microscope(SEM) results show that BiYSZ powder with stable tetragonal phase and spherical structure is nanometer level.Moreover,by using the Ac impedance spectroscopy to analyse conductivity of solid electrolytes,we find that Bi3+-doped yttria-stabilized zirconia with 4%molYO1.5 improve the ionic conductivity.Comparing all the compositions,3mol%Bi3+ doped yttria stabilized zirconia with 4%molY3+ gives the highest ionic conductivity of 7.41×10− 5 S/cm− 1 at 500℃,and sintering temperatures of BiYSZ reduce around 100℃ than Y0.04Zr0.96O2(4YSZ),ionic conductivity increases one order of magnitude.
Living with chronic headaches: A qualitative study from an outpatient pain clinic in Norway
Authors: Hervik Jill Brook , Foss Eva B. , Stub Trine
Published: May 2021

Chronic headaches are poorly managed in primary care despite a high level of morbidity. The aim of this study was to gain subjective information regarding the lives of chronic headache sufferers.MethodThis focused ethnography draws from in-depth, semi-structured interviews conducted with 16 patients who suffered from chronic headaches. Five main domains were explored in the data analysis: emotions related to headaches; trauma/stressful events; headache as a driver of behaviour; family bonding and coping mechanisms. Headache as a driver of behaviour had three subdomains: shame; loss of identity and lack of freedom.ResultsParticipants reported that pain restricted their lives in many ways. Issues included not being able to work full time and different levels of dependency on disability pension. The majority believed that trauma was the reason for their headaches. Shame and loss of identity appeared to be strongly associated with chronic pain. ConclusionThis study demonstrates that chronic headaches restrict sufferers’ lives, resulting in emotional and behavioural changes. Traumatic events of varying degrees throughout the course of life can initiate and maintain symptoms, which may become chronic and thereby have socio economic consequences, for individuals and society in general. Clinicians need to have an increased awareness as to the complexity of chronic headaches.PerspectiveThis article presents information regarding the lives of chronic headache sufferers. The findings suggests that these patients need a multidisciplinary treatment approach
Regional Cerebral Gray Matter Atrophy Is Associated With Cognitive Impairment in Hemodialysis Patients: a Cross-sectional and Longitudinal Voxel-based Morphological Mri Study
Authors: Wang Huiying , Huang Lixiang , Wu Gemuer , Li Jinping , Liu Lei , Zhang Tong , Zhu Jinxia , Zhang Xianchang , Shen Wen , Chai Chao , Xia Shuang
Published: May 2021

To explore changes of cerebral gray matter volumes (GMV) in hemodialysis patients, the clinical risk factors for GMV changes, and the relationship between GMV changes and neuropsychological tests results. Eighty-eight hemodialysis patients and seventy-six healthy controls (HCs) were recruited in this study. Fifty patients underwent follow-up magnetic resonance, blood biochemical examinations, and neuropsychological test (1.75±0.55 years). Changes in GMV between patients and HCs, longitudinal GMV changes in patients were explored. The clinical risk factors for the longitudinal GMV changes, the correlations between longitudinal GMV changes and neuropsychological tests changes in hemodialysis patients were analyzed. Compared to HCs, the hemodialysis patients had diffusely decreased in GMV (with age, sex, and total intracranial volume [TIV] as covariates, P<0.001, voxel-wise threshold false discovery rate [FDR] corrected). Compared with patients at baseline, regional decreased GMV were found in patients at follow-up (with age, and TIV as covariates, P<0.05, voxel-wise threshold FDR corrected). Increased serum urea, parathyroid hormone levels, and hemodialysis duration were independent risk factors for decreased GMV in hemodialysis patients (all P<0.05, FDR corrected). Hemodialysis patients had lower MMSE (27[26, 29]) and MoCA (22[19.48, 24.04]) scores than HCs (30[29, 30] and 28[26.89, 29]) (all P<0.05). The MMSE scores of hemodialysis patients at follow-up (26[25, 28.5]) were lower than those of patients at baseline (28[25, 29.5]) (P=0.02). The decreased left caudate volumes were positively correlated with reduced MMSE scores in hemodialysis patients (rs=0.437, P=0.033). Hemodialysis patients had diffused GM atrophy over time, which was related to cognitive impairment.
Polymethylmethacrylate-augmented Cannulated Pedicle Screw Fixation for High-energy Vertebral Compression Fracture With Osteoporosis
Authors: Liu Yao-yao , Xiao Jun , Yin Xiang , Liu Ming-Yong , Wang Zhong , He Lei , Liu Peng , Dai Fei
Published: May 2021

Background: High-energy vertebral compression fracture (HVCFs) with osteoporosis has higher requirement for the stability of pedicle screw internal fixation system. However, few studies have involved the clinical outcome of cannulated pedicle screw to augment fixation with polymethylmethacrylate (PMMA) under this condition. This study aims to investigate the mid-term efficacy of bone cement-injectable cannulated pedicle screw (CICPS) in HVCFs with osteoporosis.Methods: Eighteen patients with HVCFs (T < -2.5) were underwent spinal fixation by CICPS from 2012 to 2017. The operation time, blood loss, and hospitalization time were recorded. Pain and functional recovery were evaluated by Visual Analog Scale VAS) and Oswestry Disability Index (ODI), respectively. X-ray films were taken to evaluate the loss of vertebral height, kyphosis angle, pedicle screw loosening, and bony fusion. Surgical related complications were also recorded.Results: The average follow-up time was 18.5 ± 8.7 months (range, 6-54 months). VAS and ODI scores indicated significant improvements in postoperative pain and activity function (P < 0.05). Comparing the last follow-up with the postoperative imaging findings, the loss of vertebral height and kyphosis angle was 3.4 ± 1.2 mm and 7.8 ± 3.8°, respectively. The rate of bone graft fusion was 100% while no cases were involved in screw loosening or extraction. 1 case of superficial infection, 2 cases of PMMA leakage, and 1 case of cerebrospinal fluid leakage were found.Conclusions: CICPS fixation using PMMA augmentation may suggest as a feasible surgical technique in osteoporotic patients with HVCFs.
Abnormalities in lysine degradation are involved in the regulation of early stage compensated cardiac hypertrophy in pressure-overloaded rats
Authors: Liu Jialing , Hu Junhao , Tan Lanlan , Zhou Qi , Wu Xiaojing
Published: May 2021

Background
Cardiomyocyte metabolism changes before cardiac remodeling. However, its role in early detection of cardiac hypertrophy remains unclear. This study investigated the early changes in serum metabolomic in a pressure overload cardiac hypertrophy model induced by transverse aortic constriction (TAC).
Methods
The TAC model was constructed by partly ligating the aortic arch. Twelve Sprague-Dawley rats were randomly divided into the TAC group (n = 6) and sham group (n = 6). Three weeks after the surgery, cardiac echocardiography was performed to assess cardiac remodeling and function. HE and Masson staining were used to observe the pathologic changes. The plasma metabolites were detected by UPLC-QTOFMS and Q-TOFMS. The specific metabolites of the model were screened by orthogonal partial least squares discriminant analysis (OPLS-DA). The metabolic pathways were characterized by KEGG analysis, and the predictive value of the screened metabolites was analyzed by receiver operating characteristic (ROC) curve analysis.
Results
Three weeks after the surgery, the TAC and sham groups had similar left heart function and thickness of the interventricular septum and diastolic left ventricular posterior wall. However, in pathologic examination, the cross-sectional area of cardiac myocytes and the severity of myocardial fibrosis were significantly elevated in TAC rats. OPLS-DA analysis showed different metabolic patterns between TAC and sham groups. Based on the criterion of VIP > 1 and p < 0.05, 13 metabolites were screened out. KEGG analysis identified the disruption of the lysine degradation through the related metabolites 5-aminopentanoic acid, N6-acetyl-L-lysine, and L-lysine, with the AUC of 0.917, 0.889, and 0.806 in predicting compensated cardiac hypertrophy, respectively.
Conclusion
The disruption of lysine degradation might be involved in the early pathology of cardiac hypertrophy, and the related metabolites might be potential predictive and interventional targets for subclinical cardiac hypertrophy.
The Emission Mechanism of Gamma-ray Bursts from Supernovae
Authors: Postavaru Octavian , Craciun Marian
Published: May 2021

The connection between gamma ray bursts and supernovae is studied using a temperature-dependent vacuum model. A harmonically bound particle-antiparticle system is consistent with both Hawking radiation and Casimir effect, therefore, the Maxwell-Sellmeier model correlates the speed of light to temperature. According to quantum field theory, Lorentz invariance is violated only for temperatures larger than $4\times10^9$ K. Introducing in the temperature distribution of a 2D simulation for a type Ia supernova the speed of light temperature dependence proposed in this article, results a speed of light distribution. A theoretical snapshot of this distribution at an arbitrary distance is consistent with photon photo finish resulted from experiments. Variable speed of light shows that supernova is accompanied by gamma-ray bursts.
The impact of polymorphism in PNPLA3 and TM6SF2 genes on the susceptibility and survival of hepatitis C-related Hepatocellular carcinoma
Authors: Youssef Samar Samir , Abbas Eman Abd El Razek , Elfiky Asmaa M. , Seif Sameh , Nabeel Mohamed Mahmoud , Shousha Hend Ibrahim , Abdelaziz Ashraf Omar
Published: May 2021

Background: Genetic variants of Patatin-like phospholipase domain-containing protein3 (PNPLA3) and transmembrane 6 superfamily member 2 (TM6SF2) genes have beenreported with development of hepatocellular carcinoma (HCC). Aim: To explore therole of The PNPLA3 rs738409 and TM6SF2 rs58542926 single nucleotidepolymorphisms (SNPs) on the incidence and survival of HCV induced HCC inEgyptians.Method: This case-control study included (120) HCC and (144) HepatitisC virus (HCV) patients. Baseline clinical, laboratory, tumor characteristics data, HCCrecurrence, and overall survival were collected. PNPLA3 rs738409 and TM6SF2rs58542926 polymorphism were detected by TaqMan allelic discrimination assay.Results: HCC Patients were significantly older with male predominance. A significantdifference between TT genotype of TM6SF2 frequency was observed in HCCcompared with HCV patients. Moreover, T allele of TM6SF2 distributions revealedsignificant contribution with different stages of HCC ( p =0.03). Both PNPLA3rs738409 and TM6SF2 rs58542926 variants showed significant relation with treatmentresponse according to the modified RECIST criteria. Age and diabetes mellitus werethe independent factors associated with the development of HCC by multivariateregression analysis. Diabetes, BCLC stage, performance status and response totreatment were significantly associated with patients’ survival.Conclusion : TM6SF2 rs58542926 polymorphism not PNPLA3 rs738409 could be implicated in thedevelopment HCV induced HCC and its progression.
Pathological fracture of the jaw due to osteomyelitis after a third molar extraction
Authors: Pimentel Thais , Hadad Henrique , Jesus Laís Kawamata , Colombo Luara Teixiera , Alcantara Albertino Gomes , Souza Francisley Ávila , Gárcia-Júnior Idelmo Rangel
Published: May 2021

The osteomyelitis is an inflammatory process in bone tissue caused by an infection, commonly related to anaerobic pathogens, frequently Staphylococcus aureus and Streptococcus sp. Several causes have been related such as dentoalveolar infection, trauma, radiation and genetic condition, but it is not common after surgery for third molar extractions, especially in healthy patients. The symptoms of chronic osteomyelitis usually include signs and symptoms such as pain, edema, suppuration, areas of bone sequestration, and limited mouth opening. Among the complications associated with this condition, pathological fracture may occur due to local bone fragility. This paper aimed to report a rare case of pathological mandible fracture due to osteomyelitis after third molar extraction in a healthy male patient treated by a surgical procedure. The procedure consisted of decortication and resection of the sclerotic bone followed by reduce and fixation of mandibular fracture with one 2.4 reconstructive plate and one 2.0 plate with standard screws.
Transplante autógeno de canino superior incluso com acompanhamento de 13 anos
Authors: Mendonça José Carlos Garcia de , Santos Muryllo Eduardo Sales dos , Soruco Maria José Bazualdo , Gaetti-Jardim Ellen Cristina
Published: May 2021

O canino superior é um dos dentes que apresentam grande predisposição a impacção, a etiologia dessa problemática é incerta, uma das hipóteses levantadas é devido a ser um dos últimos dentes a erupcionar na arcada. O transplante dental é uma alternativa de tratamento em casos de dentes impactados cujo posicionamento na arcada dentaria com tracionamento ortodôntico não seja possível. Também em casos onde a exodontia seguida de reabilitação com implantes não é uma opção. O objetivo deste trabalho é relatar um caso clínico de autotransplante dental de um canino superior incluso, com rizogênese completa em um paciente de 17 anos. O caso foi acompanhado por 13 anos, mostrando um bom prognóstico, e indicando o transplante autógeno como uma ótima solução clínica, estética e social.
Features of toll-like receptor type 9 expression on immunocompetent peripheral blood cells of patients with measles infection of varying severity
Authors: Veklych Kseniia , Popov Nikolay , Liadova Tetiana , Martynenko Alexander , Volobueva Olga , Hololobova Olesia , Sorokina Olga , Salyenkova Olena , Sarkis-Ivanova Vladislava
Published: May 2021

Object of research: the level of the Toll-like receptor type 9 expression on peripheral blood lymphocytes and monocytes in patients with measles of varying severity, both with and without complications.

The solved problem: identification of the relationship between changes in the level of production of the main cytokines and virus-specific immunoglobulins and the level of expression of the Toll-like receptor type 9 on immunocompetent peripheral blood cells of patients with measles infection of varying severity.

The main scientific results: In patients with measles infection have been identified three types of cytokine response, each of which is characterized by different levels of changes in the expression of the main cytokines, immunoglobulins, and their avidity. It was shown that the levels of expression of major cytokines and virus-specific antibodies, as well as their avidity, are associated with the level of expression of the Toll-like receptor type 9. It has been demonstrated that moderate disease is associated with a significant increase in the level of expression of the Toll-like receptor type 9 on the immunocompetent peripheral blood cells, while their low expression leads to the development of severe forms of the disease. It has been shown that in moderate disease the risk of complications is associated with a lower level of expression of the Toll-like receptor compared to the group without complications. In groups of patients with a severe course of the disease a significant decrease in the level of expression of the Toll-like receptor type 9 was shown to be associated with the risk of complications.

The field of practical use of the research results: medical institutions specializing in the treatment of socially significant infectious diseases.

Innovative technological product: a method of advanced study of patients with and without measles infection of varying severity which allows to identify risk groups for the development of severe forms of the disease and complications, which in turn will allow the timely apply methods of immunomodulatory therapy and optimize the costs of the health system.

Scope of application of an innovative technological product: inpatient and outpatient treatment and diagnostics of patients with socially significant infectious diseases.
Yesus Sejarah atau Kristus Iman?: Historisitas Iman dan Karya Allah dalam Yesus Kristus
Authors: Wibowo Wahju Satria
Published: May 2021

Abstract There has always been a tension between Jesus of History and Christ of Faith. The figure of Jesus and the faith in Him as Christ are historical. History is a space to bring together both. Without Jesus of History, Christian faith is empty. Similarly, without the faith of the first Christian community, the figure of Jesus is nothing. The historicity of Jesus stands along with the historicity of faith in Him. Of course, above all is God’s work in history. On the one hand, using the research and discussion of the historical Jesus, this article shows that archaeological findings should influence Christianity to reconstruct faith, and reflects that history is a medium for God’s work. On the other hand, using some other writings this article shows that the work of God in history is the art of God’s entrepreneurship, including God’s work in Jesus Christ. Incarnational theology is based on the historical figure, Jesus of Nazareth.

Abstrak Selalu ada ketegangan antara Yesus Sejarah dan Kristus Iman. Keduanya ada dalam sejarah manusia. Sosok Yesus dan iman kepada-Nya sebagai Kristus ada dalam sejarah. Sejarah adalah ruang untuk mempertemukan keduanya. Tanpa Yesus Sejarah, iman Kristen kosong. Di sisi lain, tanpa iman komunitas Kristiani pertama, sosok Yesus menjadi tidak terlalu penting. Historisitas Yesus berada bersama dengan historisitas iman kepada-Nya. Tentu saja, di atas segalanya ada karya Allah dalam sejarah. Dengan menggunakan penelitian dan pembahasan Yesus Sejarah, artikel ini membahas bahwa temuan Yesus Sejarah seharusnya memengaruhi kekristenan untuk membangun kembali iman, dan lalu akan merefl eksikan bahwa sejarah adalah media untuk pekerjaan Allah. Di sisi lain, dengan menggunakan beberapa tulisan lain artikel ini menunjukkan bahwa karya Allah dalam sejarah adalah “seni kewirausahaan Allah”, termasuk karya Allah dalam Yesus Kristus. Teologi inkarnasional didasarkan pada tokoh sejarah, Yesus dari Nazaret.
Parenting Styles, Anxiety and Depressive Symptoms in Child/Adolescent
Authors: Romero-Acosta Kelly , Gómez-de-Regil Lizzette , Lowe Gillian A. , Garth E. Lipps , Gibson Roger C.
Published: May 2021

Objective: To analyse the possible direct and interactive associations of sex, age and parenting styles with symptoms of depression and anxiety. Methods: In this cross-sectional study, 710 students ranging from 8 to 13 years (mean age 10.8 years [±0.75]), the most of them males (n = 422,59.4%), completed three screening instruments: a parenting practices scale and two self-reports for evaluating anxiety and depressive symptoms. Two hierarchical multiple regression analyses were performed. Results: Authoritative (38.6%) and neglectful (38%) parenting styles were predominant. Symptoms of depression —F(3,706) = 3.12,p = .03— and anxiety —F(3,706) = 2.83,p = .4— differed by parenting styles. Students with a neglectful parenting style reported significant lower generalized anxiety symptoms than those whose parents used authoritative parenting. Clinical implications: Children ages 8 to 13 years-old with authoritative  parenting style should be evaluated for possible presence of generalized anxiety symptoms.
The Impact of Employee Engagement on Organization’s Productivity on United Methods on Relief Services
Authors: Irene Ayot
Published: May 2021

Employee engagement has arisen as a widespread organizational perception in current years. It is the level of strength of mental and emotional connection employees feel toward their workplaces and its values and beliefs. When employees are engaged and aware of the business framework and work as a team to improve performance within the job for the advantage of the organization. Employee engagement resourcefulness has a straight effect on the organization's level of production. Every company/ organization requires their workers to be engaged in their respective work. Employee engagement is linked to customer satisfaction which is connected to an organization's financial success. Engagement arises when adequate individuals give attention to performing good work and care concerned about what the company is thriving to attain and in what way it is an accomplishment. This helpful mentality and behavior only arise once people get satisfied with their jobs they do and are convinced that the organization supports them, with an effective HR manager. This paper covers a literature review from several study findings and practices employed by the use of an expressive research method. It schemes the effect of worker’s engagement on the productivity of the organization. It also showcased the factors affecting the worker’s assignation and organizational results.
Ablation of a life-threatening arrhythmia in a patient with Brugada syndrome
Authors: Kamel Omnia , Gamal Wessam , Tarek Aliaa , Ibrahim Walaa , Sayed Mohamed , Brugada Josep , Moreno Javier
Published: May 2021

Brugada syndrome is an autosomal dominant arrhythmogenic disease associated with an increased risk of ventricular fibrillation and sudden cardiac death. The mainstay of treatment in high-risk patients is an implantable cardioverter-defibrillator (ICD), however radiofrequency ablation has been proposed over the past decade as an additional therapy in patients with recurrent ICD firing.We report a case of Brugada syndrome with an electrical storm which was successfully managed by radiofrequency ablation.
Cardiovascular adverse events in pregnancy: A global perspective
Authors: Kotit Susy , Yacoub Magdi
Published: May 2021

Pregnant women with heart disease are vulnerable to many adverse cardiovascular events (AE). AEs during and after pregnancy continue to be important causes of maternal mortality and morbidity worldwide, with huge variations in burden in different countries and regions. These AEs are classified as having direct or indirect causes, depending on whether they are directly caused by pregnancy or due to some pre-existing disease and/or non-obstetric cause, respectively.The risks continue throughout pregnancy and even after childbirth. Apart from immediate complications during pregnancy, there is increasing evidence of a significant link between several events and the risk of cardiovascular disease (CVD) later in life.A significant number of pregnancy-related deaths caused by cardiovascular disease are preventable. This prevention can be realized through increasing awareness of cardiovascular AE in pregnancy, coupled with the application of strategies for prevention and treatment. Knowledge of the risks associated with CVD and pregnancy is of extreme importance in that regard.We discuss the global distribution of cardiovascular maternal mortality, adverse events during and after pregnancy, their predictors and risk stratification. In addition, we enumerate possible solutions, particularly the role of cardio-obstetric clinics.
Pengaruh Sinbiotik Kefir Tepung Pisang Batu (Musa balbisiana) terhadap Kadar Kolesterol Total dan Kadar Trigliserida Tikus Model Sindrom Metabolik
Authors: Sari Diana Martha Ariesta , Maryusman Taufik , Herlina Santi
Published: May 2021

This study was conducted to analyze the effects of banana (Musa balbisiana) flour kefir synbiotic on total cholesterol level and triglyceride level of Metabolic Syndrome rats model. This research used a true experimental method with pre-post test control group design. The number of 24 rats model were randomly divided into four groups, i.e. K– (healthy rats, standard diet), K+ (Metabolic Syndrome rats, standard diet), PI (Metabolic Syndrome rats, standard diet and synbiotic 1,8 ml/200grBW/day), and PII (Metabolic Syndrome rats, standard diet and synbiotic 3,6 ml/200grBW/day), with intervention duration of 3 weeks. Blood draws were carried out at the beginning and end session of the intervention to analyze total cholesterol and triglyceride levels. The data from the measurement of total cholesterol and triglyceride levels before and after the intervention were then analyzed using the Paired T-Test. The results of the Paired T-Test showed differences (p
Interaction of Kurdology with the Russian Empire’s Foreign Policy Towards the Ottoman Kurds
Authors: BAŞARAN Ali
Published: May 2021

The aim of the present research is to determine whether or not there was interaction between the Russian Empire’s policy towards Kurds and the course of Kurdology in the Russian Empire. It is accepted that discrepancies within adversarial nation-states are highlighted through differences in religion, sect, tribe, and region. Therefore, those of the knowledgeable and able, who for example speak the language of the majority nation, are called upon to create a political opposition in a rival state. For this purpose, institutions were established for confidential or open intelligence, production, and publication of information. And, the role of Kurdology in creating or highlighting differences regarding actualization of political opposition can be determined. The present article analyzes the collection of information about Kurds in the Russian Empire/RE and the effect of the Russian Empire’s policies on their formulation. From this point of view, the works in the Russian State Library with a title containing the word “Kurds” are interpreted according to year, type, and languages, taking into consideration the persons involved in their preparation. The resultant conclusion is that Kurdology in the Russian Empire is seen to have interacted with the policies of the Russian Empire.
In Situ Gene Therapy
Authors: Santos Hallana Souza , Rodrigues Luiza , Vera Luisa Natalia Pimentel , Poletto Edina , Filippi-Chiela Eduardo , dos Santos Bruschi Lia Franciê Ribeiro , Schuh Roselena , Baldo Guilherme
Published: May 2021

Gene therapy is a technique that aims at the delivery of nucleic acids to cells, to obtain a
therapeutic effect. In situ gene therapy consists of the administration of the gene product to a specific
site. It possesses several advantages, such as the reduction in potential side effects, the need for a lower
vector dose, and, as a consequence, reduced costs, compared to intravenous administration. Different
vectors, administration routes and doses involving in situ gene transfer have been tested both in
animal models and humans, with in situ gene therapy drugs already approved in the market. In this review,
we present applications of in situ gene therapy for different diseases, ranging from monogenic to
multifactorial diseases, focusing mainly on therapies designed for the intra-articular and intraocular
compartments, as well as gene therapies for the central nervous system (CNS) and for tumors. Gene
therapy finally seems to blossom as a viable therapeutic approach. The growth in the number of clinical
protocols shown here is evident, and the positive outcomes observed in several clinical trials indicate
that more products based on in situ gene therapy should reach the market in the next years.
Why is the Incidence of Type 1 Diabetes Increasing?
Authors: Abela Alexia G. , Fava Stephen
Published: May 2021

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Type 1 diabetes is a condition that can lead to serious long-term complications and can
have significant psychological and quality of life implications. Its incidence is increasing in all
parts of the world, but the reasons for this are incompletely understood. Genetic factors alone cannot
explain such a rapid increase in incidence; therefore, environmental factors must be implicated.

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Lifestyle factors have been classically associated with type 2 diabetes. However, there are data implicating
obesity and insulin resistance to type 1 diabetes as well (accelerator hypothesis). Cholesterol
has also been shown to be correlated with the incidence of type 1 diabetes; this may be mediated
by immunomodulatory effects of cholesterol. There is considerable interest in early life factors,
including maternal diet, mode of delivery, infant feeding, childhood diet, microbial exposure (hygiene
hypothesis), and use of anti-microbials in early childhood.

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Distance from the sea has recently been shown to be negatively correlated with the incidence of
type 1 diabetes. This may contribute to the increasing incidence of type 1 diabetes since people are
increasingly living closer to the sea. Postulated mediating mechanisms include hours of sunshine
(and possibly vitamin D levels), mean temperature, dietary habits, and pollution. Ozone, polychlorinated
biphenyls, phthalates, trichloroethylene, dioxin, heavy metals, bisphenol, nitrates/nitrites,
and mercury are amongst the chemicals which may increase the risk of type 1 diabetes.

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Another area of research concerns the role of the skin and gut microbiome. The microbiome is affected
by many of the factors mentioned above, including the mode of delivery, infant feeding, exposure
to microbes, antibiotic use, and dietary habits. Research on the reasons why the incidence of
type 1 diabetes is increasing not only sheds light on its pathogenesis but also offers insights into
ways we can prevent type 1 diabetes.