bluuebunny/crossref_metadata_2025 huggingface dataset:
Network Pharmacology of Red Ginseng (Part I): Effects of Ginsenoside Rg5 at Physiological and Sub-Physiological Concentrations
Authors: Panossian Alexander , Abdelfatah Sara , Efferth Thomas
Published: September 2021

Numerous in vitro studies on isolated cells have been conducted to uncover the molecular mechanisms of action of Panax ginseng Meyer root extracts and purified ginsenosides. However, the concentrations of ginsenosides and the extracts used in these studies were much higher than those detected in pharmacokinetic studies in humans and animals orally administered with ginseng preparations at therapeutic doses. Our study aimed to assess: (a) the effects of ginsenoside Rg5, the major “rare” ginsenoside of Red Ginseng, on gene expression in the murine neuronal cell line HT22 in a wide range of concentrations, from 10−4 to 10−18 M, and (b) the effects of differentially expressed genes on cellular and physiological functions in organismal disorders and diseases. Gene expression profiling was performed by transcriptome-wide mRNA microarray analyses in HT22 cells after treatment with ginsenoside Rg5. Ginsenoside Rg5 exhibits soft-acting effects on gene expression of neuronal cells in a wide range of physiological concentrations and strong reversal impact at high (toxic) concentration: significant up- or downregulation of expression of about 300 genes at concentrations from 10−6 M to 10−18 M, and dramatically increased both the number of differentially expressed target genes (up to 1670) and the extent of their expression (fold changes compared to unexposed cells) at a toxic concentration of 10−4 M. Network pharmacology analyses of genes’ expression profiles using ingenuity pathway analysis (IPA) software showed that at low physiological concentrations, ginsenoside Rg5 has the potential to activate the biosynthesis of cholesterol and to exhibit predictable effects in senescence, neuroinflammation, apoptosis, and immune response, suggesting soft-acting, beneficial effects on organismal death, movement disorders, and cancer.
Nano DNA Vaccine Encoding Toxoplasma gondii Histone Deacetylase SIR2 Enhanced Protective Immunity in Mice
Authors: Yu Zhengqing , Lu Yujia , Cao Wandi , Aleem Muhammad Tahir , Liu Junlong , Luo Jianxun , Yan Ruofeng , Xu Lixin , Song Xiaokai , Li Xiangrui
Published: September 2021

The pathogen of toxoplasmosis, Toxoplasma gondii (T. gondii), is a zoonotic protozoon that can affect the health of warm-blooded animals including humans. Up to now, an effective vaccine with completely protection is still inaccessible. In this study, the DNA vaccine encoding T. gondii histone deacetylase SIR2 (pVAX1-SIR2) was constructed. To enhance the efficacy, chitosan and poly (d, l-lactic-co-glycolic)-acid (PLGA) were employed to design nanospheres loaded with the DNA vaccine, denoted as pVAX1-SIR2/CS and pVAX1-SIR2/PLGA nanospheres. The pVAX1-SIR2 plasmids were transfected into HEK 293-T cells, and the expression was evaluated by a laser scanning confocal microscopy. Then, the immune protections of pVAX1-SIR2 plasmid, pVAX1-SIR2/CS nanospheres, and pVAX1-SIR2/PLGA nanospheres were evaluated in a laboratory animal model. The in vivo findings indicated that pVAX1-SIR2/CS and pVAX1-SIR2/PLGA nanospheres could generate a mixed Th1/Th2 immune response, as indicated by the regulated production of antibodies and cytokines, the enhanced maturation and major histocompatibility complex (MHC) expression of dendritic cells (DCs), the induced splenocyte proliferation, and the increased percentages of CD4+ and CD8+ T lymphocytes. Furthermore, this enhanced immunity could obviously reduce the parasite burden in immunized animals through a lethal dose of T. gondii RH strain challenge. All these results propose that pVAX1-SIR2 plasmids entrapped in chitosan or PLGA nanospheres could be the promising vaccines against acute T. gondii infections and deserve further investigations.
Understanding Direct Powder Extrusion for Fabrication of 3D Printed Personalised Medicines: A Case Study for Nifedipine Minitablets
Authors: Sánchez-Guirales Sergio A. , Jurado Noelia , Kara Aytug , Lalatsa Aikaterini , Serrano Dolores R.
Published: September 2021

Fuse deposition modelling (FDM) has emerged as a novel technology for manufacturing 3D printed medicines. However, it is a two-step process requiring the fabrication of filaments using a hot melt extruder with suitable properties prior to printing taking place, which can be a rate-limiting step in its application into clinical practice. Direct powder extrusion can overcome the difficulties encountered with fabrication of pharmaceutical-quality filaments for FDM, allowing the manufacturing, in a single step, of 3D printed solid dosage forms. In this study, we demonstrate the manufacturing of small-weight (<100 mg) solid dosage forms with high drug loading (25%) that can be easily undertaken by healthcare professionals to treat hypertension. 3D printed nifedipine minitablets containing 20 mg were manufactured by direct powder extrusion combining 15% polyethylene glycol 4000 Da, 40% hydroxypropyl cellulose, 19% hydroxy propyl methyl cellulose acetate succinate, and 1% magnesium stearate. The fabricated 3D printed minitablets of small overall weight did not disintegrate during dissolution and allowed for controlled drug release over 24 h, based on erosion. This release profile of the printed minitablets is more suitable for hypertensive patients than immediate-release tablets that can lead to a marked burst effect, triggering hypotension. The small size of the minitablet allows it to fit inside of a 0-size capsule and be combined with other minitablets, of other API, for the treatment of complex diseases requiring polypharmacy within a single dosage form.
The Revolving Door of Adenovirus Cell Entry: Not All Pathways Are Equal
Authors: Nestić Davor , Božinović Ksenija , Pehar Isabela , Wallace Rebecca , Parker Alan L. , Majhen Dragomira
Published: September 2021

Adenoviruses represent exceptional candidates for wide-ranging therapeutic applications, from vectors for gene therapy to oncolytics for cancer treatments. The first ever commercial gene therapy medicine was based on a recombinant adenovirus vector, while most recently, adenoviral vectors have proven critical as vaccine platforms in effectively controlling the global coronavirus pandemic. Here, we discuss factors involved in adenovirus cell binding, entry, and trafficking; how they influence efficiency of adenovirus-based vectors; and how they can be manipulated to enhance efficacy of genetically modified adenoviral variants. We focus particularly on endocytosis and how different adenovirus serotypes employ different endocytic pathways to gain cell entry, and thus, have different intracellular trafficking pathways that subsequently trigger different host antiviral responses. In the context of gene therapy, the final goal of the adenovirus vector is to efficiently deliver therapeutic transgenes into the target cell nucleus, thus allowing its functional expression. Aberrant or inefficient endocytosis can impede this goal, therefore, it should be considered when designing and constructing adenovirus-based vectors.
Performance Evaluation of Solid-State Laser Gain Module by Measurement of Thermal Effect and Energy Storage
Authors: Park Daewoong , Jeong Jihoon , Hwang Seungjin , Lee Sungyoon , Cho Seryeyohan , Yu Tae Jun
Published: September 2021

The optimization of solid-state laser cavities requires a deep understanding of the gain module, the most critical laser component. This study proposes a procedure for evaluating the performance of the solid-state laser gain module. The thermal effect and energy storage characteristics are the performance criteria. A normalized heating parameter was calculated as a quantitative indicator of the performance criteria. We proposed a method to quantify the heat dissipated into the gain medium using the wavefront distortion, thermal deformation theory of the gain medium, and the ray transfer matrix method. The suggested procedure was verified by evaluating the flashlamp type Nd:YAG rod gain module, but it can also even be extended to other solid-state laser gain modules by applying the appropriate thermal deformation theory.
The Arabidopsis Rho of Plants GTPase ROP1 Is a Potential Calcium-Dependent Protein Kinase (CDPK) Substrate
Authors: Ménesi Dalma , Klement Éva , Ferenc Györgyi , Fehér Attila
Published: September 2021

Plant Rho-type GTPases (ROPs) are versatile molecular switches involved in a number of signal transduction pathways. Although it is well known that they are indirectly linked to protein kinases, our knowledge about their direct functional interaction with upstream or downstream protein kinases is scarce. It is reasonable to suppose that similarly to their animal counterparts, ROPs might also be regulated by phosphorylation. There is only, however, very limited experimental evidence to support this view. Here, we present the analysis of two potential phosphorylation sites of AtROP1 and two types of potential ROP-kinases. The S74 site of AtROP1 has been previously shown to potentially regulate AtROP1 activation dependent on its phosphorylation state. However, the kinase phosphorylating this evolutionarily conserved site could not be identified: we show here that despite of the appropriate phosphorylation site consensus sequences around S74 neither the selected AGC nor CPK kinases phosphorylate S74 of AtROP1 in vitro. However, we identified several phosphorylation sites other than S74 for the CPK17 and 34 kinases in AtROP1. One of these sites, S97, was tested for biological relevance. Although the mutation of S97 to alanine (which cannot be phosphorylated) or glutamic acid (which mimics phosphorylation) somewhat altered the protein interaction strength of AtROP1 in yeast cells, the mutant proteins did not modify pollen tube growth in an in vivo test.
Anti-Demineralization Effects of Dental Adhesive-Composites on Enamel–Root Dentin Junction
Authors: Lai Yu-Jung , Takahashi Rena , Lin Po-Yen , Kuo Ling , Zhou Yuan , Matin Khairul , Chiang Yu-Chih , Shimada Yasushi , Tagami Junji
Published: September 2021

Oral biofilm reactor (OBR) and pH cycling (pHC) artificial caries model were employed to evaluate the anti-demineralization effects of four composite filling systems on enamel–root dentin junction. Sixty-four enamel–root dentin blocks (6 mm × 6 mm × 2 mm) each with a cylindrical cavity were randomly assigned to the pHC and OBR group, then four subgroups (n = 8) and filled with either the Beautifil II (BEF, SPRG-filler-containing) or Estelite (EST) composite after the adhesive (either Single Bond Universal (SBU) or FL Bond II (FL, SPRG-filler-containing)). The demineralization lesions of filling interface were examined by micro-computerized tomography (μCT) and swept-source-optical coherence tomography (SS-OCT). According to the degree of interface damage, the caries lesions were sorted into four types: Type A and B (no attachment loss); Type C and D (attachment loss). EST/SBU showed the worst demineralization lesion and attachment loss (100% Type D), while BEF/FL exhibited the shallowest lesion depth (p < 0.05, 145 ± 45 μm on enamel, 275 ± 35 μm on root dentin) and no attachment loss (75% Type A and 25% Type B). Using FL adhesive alone does not effectively reduce enamel demineralization. BEF plays a leading role in acid resistance. The combination of BEF and FL showed a cumulative synergistic effect on anti-demineralization.
Nanoindentation Reveals Crosslinking Behavior of Solar Encapsulants—The Methodological Advantages over Bulk Methods
Authors: Mansour Djamel Eddine , Herzog Christoph , Christöfl Petra , Pitta Bauermann Luciana , Oreski Gernot , Schuler Andreas , Philipp Daniel , Gebhardt Paul
Published: September 2021

The power degradation and failure of photovoltaic (PV) modules can be caused by changes in the mechanical properties of the polymeric components during the module lifetime. This paper introduces instrumented nanoindentation as a method to investigate the mechanical properties of module materials such as polymeric encapsulants. To this end, nanoindentation tests were carried out on ethylene vinyl acetate (EVA) surfaces, which have been separated from the glass panel. Two types of time-dependent indentation cycle modes, the time domain (creep mode) and frequency domain (dynamic mode) were performed to determine the viscoelastic behavior. For each mode, a corresponding model was applied to calculate the main mechanical properties. The general capability of nanoindentation as cross-linking determination method is investigated with the methodological advantages over bulk mechanical characterization methods. A large number of Glass/EVA/Backsheet laminates were built using different lamination conditions resulting in different degrees of curing. Both indentation modes indicate good modulus sensitivity for following the EVA crosslinking in its early stages but could not reliably differentiate between samples with higher EVA branching. Additional dynamic mechanical analysis (DMA) characterization was used as an established method to validate the indentation measurements. Both nanoindentation and DMA tensile mode produce similar quantitative viscoelastic responses, in the form of the damping factor parameter, demonstrated for three different frequencies at room temperature. A statistical study of the data reveals the advantages for the investigation of multilayer PV laminates by using nanoindenation as a surface method while also being applicable to field aged modules.
cis-1,4 Selective Coordination Polymerization of 1,3-Butadiene and Copolymerization with Polar 2-(4-Methoxyphenyl)-1,3-butadiene by Acenaphthene-Based α-Diimine Cobalt Complexes Featuring Intra-Ligand π-π Stacking Interactions
Authors: Wang Beibei , Liu Heng , Tang Tao , Zhang Xuequan
Published: September 2021

Highly cis-1,4 selective (up to 98%) coordination–insertion polymerization of 1,3-butadiene (BD) has been achieved herein using acenaphthene-based α-diimine cobalt complexes. Due to the presence of intra-ligand π-π stacking interactions, the complexes revealed high thermostability, affording polybutadiene products in high yields. Moreover, all of the obtained polymers possessed a relatively narrow molecular weight distribution as well as high molecular weight (up to 92.2 × 104 Dalton). The molecular weights of the resultant polybutadienes could be finely tuned by varying polymerization parameters, including temperature, Al/Co ratio, etc. Moreover, the copolymerization of butadiene with polar monomer 2-(4-methoxyphenyl)-1,3-butadiene (2-MOPB) was also successfully realized to produce a type of polar cis-1,4 polybutadiene (cis-1,4 content: up to 98.1%) with a range of 2-MOPB content (0.46–1.83%). Water contact angle measurements indicated that the insertion of a polar monomer into a polymer chain could significantly improve the polymer’s surface property.
Monomeric and Dimeric Carboxylic Acid in Crystalline Cavities and Channels of Delta and Epsilon Forms of Syndiotactic Polystyrene
Authors: Cozzolino Antonietta , Monaco Guglielmo , Daniel Christophe , Rizzo Paola , Guerra Gaetano
Published: September 2021

Delta (δ) and epsilon (ε) co-crystalline forms of syndiotactic polystyrene with a carboxylic acid guest were obtained by sorption of liquid hexanoic acid in syndiotactic polystyrene films exhibiting delta and epsilon nanoporous-crystalline forms. The characterization study is facilitated by axially stretched syndiotactic polystyrene films, used both for polarized FTIR spectra and for WAXD fiber patterns. Particularly informative are two carbonyl-stretching FTIR peaks, attributed to monomeric and dimeric hexanoic acid. The dichroism of these carbonyl peaks indicates that both delta and epsilon phases are able to include hexanoic acid as isolated guest molecules, while only the epsilon phase is also able to include dimeric hexanoic acid molecules in its crystalline channels. The inclusion of both isolated and dimeric hexanoic acid species in the epsilon form crystalline channels produces extremely fast hexanoic acid uptakes by syndiotactic polystyrene epsilon form films.
Nanopatterned Polymer Molds Using Anodized Aluminum Templates for Anti-Reflective Coatings
Authors: Lim Soon Hyuk , Ly Nguyễn Hoàng , Lee Jung A. , Kim Ji Eun , La Se-Woong , Huong Vu Thi , Tran Thi-Giang , Ho Ngoc Thanh , Noh Seung Man , Son Sang Jun , Joo Sang-Woo
Published: September 2021

This work introduces a facile geometry-controlled method for the fabrication of embossed and engraved polymeric moth-eye-inspired nanostructures in imprinting molds using anodic aluminum oxide (AAO) templates, resulting in a novel anti-reflective transparent coating. The moth-eye nanostructures are prepared directly on the surface of a flexible polyethylene terephthalate (PET) substrate. As a prerequisite procedure, a UV-curable polyurethane acrylate resin is spun on the PET. The shape of the moth-eye nanostructures can then be adjusted by controlling the size and shape of the nanopores in the AAO templates. Both embossed and concaved polymer moth-eye nanostructures were successfully mounted on a PET substrate. Embossed polymer replica molds were prepared using the AAO master templates in combination with an imprinting process. As revealed by field-emission electron microscope (FE-SEM) images, conical nanopatterns in the AAO template with a diameter of ~90 nm and a depth of ~100 nm, create a homogeneous embossed morphology in the polymer moth-eye nanostructure. The polymeric molds with the depths of 300 and 500 nm revealed the amalgamated structures in their apexes. In addition, a dip-imprinting process of the polymeric layers was implemented to yield a concaved mold by assembly on the surface of the 100 nm embossed polymer mold substrate. Considering that the embossed structures may be crumbled due to their protuberant shapes, the concaved geometries can have an advantage of stability in a certain application concerning physical degradation along with a higher transmission by ~2%, despite somewhat nonuniform structure. The experimental and theoretical results of this study indicate that this polymer layer has the potential for use in anti-reflective coating applications in transparent films.
Recent Advances on Thermally Conductive Adhesive in Electronic Packaging: A Review
Authors: Alim Md. Abdul , Abdullah Mohd Zulkifly , Aziz Mohd Sharizal Abdul , Kamarudin R. , Gunnasegaran Prem
Published: September 2021

The application of epoxy adhesive is widespread in electronic packaging. Epoxy adhesives can be integrated with various types of nanoparticles for enhancing thermal conductivity. The joints with thermally conductive adhesive (TCA) are preferred for research and advances in thermal management. Many studies have been conducted to increase the thermal conductivity of epoxy-based TCAs by conductive fillers. This paper reviews and summarizes recent advances of these available fillers in TCAs that contribute to electronic packaging. It also covers the challenges of using the filler as a nano-composite. Moreover, the review reveals a broad scope for future research, particularly on thermal management by nanoparticles and improving bonding strength in electronic packaging.
Polysaccharide-Based Micro- and Nanosized Drug Delivery Systems for Potential Application in the Pediatric Dentistry
Authors: Katsarov Plamen , Shindova Maria , Lukova Paolina , Belcheva Ani , Delattre Cédric , Pilicheva Bissera
Published: September 2021

The intensive development of micro- and nanotechnologies in recent years has offered a wide horizon of new possibilities for drug delivery in dentistry. The use of polymeric drug carriers turned out to be a very successful technique for formulating micro- and nanoparticles with controlled or targeted drug release in the oral cavity. Such innovative strategies have the potential to provide an improved therapeutic approach to prevention and treatment of various oral diseases not only for adults, but also in the pediatric dental practice. Due to their biocompatibility, biotolerance and biodegradability, naturally occurring polysaccharides like chitosan, alginate, pectin, dextran, starch, etc., are among the most preferred materials for preparation of micro- and nano-devices for drug delivery, offering simple particle-forming characteristics and easily tunable properties of the formulated structures. Their low immunogenicity and low toxicity provide an advantage over most synthetic polymers for the development of pediatric formulations. This review is focused on micro- and nanoscale polysaccharide biomaterials as dental drug carriers, with an emphasis on their potential application in pediatric dentistry.
Dynamic Mechanical Properties and Thermal Properties of Longitudinal Basalt/Woven Glass Fiber Reinforced Unsaturated Polyester Hybrid Composites
Authors: Haris Nur Izzah Nabilah , Ilyas R. A. , Hassan Mohamad Zaki , Sapuan S. M. , Afdzaluddin Atiqah , Jamaludin Khairur Rijal , Zaki Sheikh Ahmad , Ramlie Faizir
Published: September 2021

This study investigates the mechanical, thermal, and chemical properties of basalt/woven glass fiber reinforced polymer (BGRP) hybrid polyester composites. The Fourier transform infrared spectroscopy (FTIR) was used to explore the chemical aspect, whereas the dynamic mechanical analysis (DMA) and thermomechanical analysis (TMA) were performed to determine the mechanical and thermal properties. The dynamic mechanical properties were evaluated in terms of the storage modulus, loss modulus, and damping factor. The FTIR results showed that incorporating single and hybrid fibers in the matrix did not change the chemical properties. The DMA findings revealed that the B7.5/G22.5 composite with 7.5 wt% of basalt fiber (B) and 22.5 wt% of glass fiber (G) exhibited the highest elastic and viscous properties, as it exhibited the higher storage modulus (8.04 × 109 MPa) and loss modulus (1.32 × 109 MPa) compared to the other samples. All the reinforced composites had better damping behavior than the neat matrix, but no further enhancement was obtained upon hybridization. The analysis also revealed that the B22.5/G7.5 composite with 22.5 wt% of basalt fiber and 7.5 wt% of glass fiber had the highest Tg at 70.80 °C, and increased by 15 °C compared to the neat matrix. TMA data suggested that the reinforced composites had relatively low dimensional stabilities than the neat matrix, particularly between 50 to 80 °C. Overall, the hybridization of basalt and glass fibers in unsaturated polyester formed composites with higher mechanical and thermal properties than single reinforced composites.
Development, Investigation, and Comparative Study of the Effects of Various Metal Oxides on Optical Electrochemical Properties Using a Doped PANI Matrix
Authors: Bekhoukh Amina , Moulefera Imane , Sabantina Lilia , Benyoucef Abdelghani
Published: September 2021

A comparative study was performed in order to analyze the effect of metal oxide (MO) on the properties of a polymeric matrix. In this study, polyaniline (PANI)@Al2O3, PANI@TiC, and PANI@TiO2 nanocomposites were synthesized using in situ polymerization with ammonium persulfate as an oxidant. The prepared materials were characterized by various analytical methods such as X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), thermogravimetric analysis (TGA), UV/visible (UV/Vis) spectroscopy, Fourier-transform infrared spectroscopy (FTIR), and transmission electron microscopy (TEM). Furthermore, the conductive properties of the materials were tested using the four-point probe method. The presence of MO in the final product was confirmed by XPS, XRD, FTIR, and TEM, while spectroscopic characterization revealed interactions between the MOs and PANI. The results showed that the thermal stability was improved when the MO was incorporated into the polymeric matrix. Moreover, the results revealed that incorporating TiO2 into the PANI matrix improves the optical bandgap of the nanocomposite and decreases electrical conductivity compared to other conducting materials. Furthermore, the electrochemical properties of the hybrid nanocomposites were tested by cyclic voltammetry (CV) and galvanostatic charge/discharge (GCD). The obtained results suggest that the PANI@TiO2 nanocomposite could be a promising electrode material candidate for high-performance supercapacitor applications.
Chitosan-Coated 5-Fluorouracil Incorporated Emulsions as Transdermal Drug Delivery Matrices
Authors: Khan Taif Ali , Azad Abul Kalam , Fuloria Shivkanya , Nawaz Asif , Subramaniyan Vetriselvan , Akhlaq Muhammad , Safdar Muhammad , Sathasivam Kathiresan V. , Sekar Mahendran , Porwal Omji , Meenakshi Dhanalekshmi Unnikrishnan , Malviya Rishabha , Miret Mireia Mallandrich , Mendiratta Ajay , Fuloria Neeraj Kumar
Published: September 2021

The purpose of the present study was to develop emulsions encapsulated by chitosan on the outer surface of a nano droplet containing 5-fluorouracil (5-FU) as a model drug. The emulsions were characterized in terms of size, pH and viscosity and were evaluated for their physicochemical properties such as drug release and skin permeation in vitro. The emulsions containing tween 80 (T80), sodium lauryl sulfate, span 20, and a combination of polyethylene glycol (PEG) and T20 exhibited a release of 88%, 86%, 90% and 92%, respectively. Chitosan-modified emulsions considerably controlled the release of 5-FU compared to a 5-FU solution (p < 0.05). All the formulations enabled transportation of 5-FU through a rat’s skin. The combination (T80, PEG) formulation showed a good penetration profile. Different surfactants showed variable degrees of skin drug retention. The ATR-FTIR spectrograms revealed that the emulsions mainly affected the fluidization of lipids and proteins of the stratum corneum (SC) that lead to enhanced drug permeation and retention across the skin. The present study concludes that the emulsions containing a combination of surfactants (Tween) and a co-surfactant (PEG) exhibited the best penetration profile, prevented the premature release of drugs from the nano droplet, enhanced the permeation and the retention of the drug across the skin and had great potential for transdermal drug delivery. Therefore, chitosan-coated 5-FU emulsions represent an excellent possibility to deliver a model drug as a transdermal delivery system.
Effect of Processing Techniques on the Microstructure and Mechanical Performance of High-Density Polyethylene
Authors: Mejia Edgar , Cherupurakal Nizamudeen , Mourad Abdel-Hamid I. , Al Hassanieh Sultan , Rabia Mohamed
Published: September 2021

The versatility of high-density polyethylene (HDPE) makes it one of the most used polymers for vast applications ranging from food packaging to human implants. However, there still is confusion regarding the proper selection of processing techniques to produce HDPE specimens for high-end applications. Herein, we compare the processing of HDPE by two relevant techniques: compression and injection molding. The fabricated samples were studied using uniaxial tensile testing to determine their mechanical performance. Furthermore, the microstructure of samples was analyzed using different characterization techniques. Compression-molded specimens recorded a higher degree of crystallinity (DC) using two different characterization techniques such as differential scanning calorimetry (DSC) and X-ray diffraction (XRD). With this information, critical processing factors were determined, and a general structure–property relationship was established. It was demonstrated that having a higher DC resulted in higher yield strength and Young’s modulus. Furthermore, premature failure was observed in the injection-molded specimens, resulting in lower mechanical performance. This premature failure was caused due to flow marks observed using scanning electron microscopy (SEM). Therefore, it is concluded that compression molding produces superior samples compared to injection molding.
Research on the Path of Manufacturing Enterprises Supply Chain Integration from the Configuration Perspective
Authors: Yang Hongxiong , Wang Yunpeng
Published: September 2021

In digital transformation and development, supply chain integration has become a key strategy to improve supply chain synergy efficiency and enhance enterprise competitiveness. Based on the survey data of 185 manufacturing enterprises in Tianjin, the fuzzy set qualitative comparative analysis (fs QCA) method is used to explore the synergistic mechanism of government policy, supply chain partnership, information sharing, risk avoidance, and intelligence degree on supply chain integration and the interaction among them. The results show that: (1) a single factor does not constitute a necessary condition for promoting supply chain integration, but the formation and development of supply chain partnership plays a universal role in promoting supply chain integration; (2) the “multiple concurrent” of five factors constitute the diversified configuration of a driving supply chain integration path, that is, the driving supply chain integration path has the characteristic of “all roads lead to the same destination”; (3) there is a “sharing” type, a “cooperative” type, and a “cooperative-sharing” type three equivalent path, whereby the formation of supply chain partnership can enhance the trust between manufacturing enterprises and suppliers and customers, increase the transaction frequency of upstream and downstream enterprises, and improve the cooperation efficiency. The utility model can effectively reduce the “long whip” problem caused by the information asymmetry, and improve the operational efficiency and stability of the whole supply chain. The purpose of this study is to inspire manufacturing enterprises in the context of digital supply chain integration to improve the collaborative efficiency of the supply chain.
Reassessment of the Mollusc Gleaning Fishery in Malalison Island, Antique Province, West Central Philippines
Authors: VILLARTA KAREN , DEL NORTE CAMPOS ANNABELLE GLENDA DEL NORTE CAMPOS , BURGOS-NUÑEZA LORELIE
Published: September 2021

Gleaning activity in Malalison Island in Culasi, Antique, Philippines, was revisited and monitored monthly from May 2018 to April 2020 to compare with results from a previous investigation in 2003. Overall, slight differences were noted in the daily catch, effort, and catch rates between 2003 and 2020, whereas substantial differences were observed in the monthly and annual catches. A total of 26 species of molluscs were recorded, which was slightly lower than the previous number (= 30), dominated by the gastropods, Nerita albicilla Linnaeus, 1758, Nerita polita Linnaeus, 1758, Canarium urceus (Linnaeus, 1758), Conomurex luhuanus (Linnaeus, 1758), and Angaria delphinus (Linnaeus, 1758) which represented 79 % of the catch. The mean daily catch was 1.15 kg.gleaner-1 with catch rates ranging from 0.8 to 1.6 kg.day-1.gleaner-1, was slightly lower than the estimates in 2003 (0.9 to 2.5 kg.day-1). The observed mean monthly catch (29.6 kg) was considerably higher than the 2003 estimate (6.1 kg), which subsequently resulted in a higher estimated annual catch (1,867–2,178 kg), value (USD2,352–2,783), and gleaner income (USD392–464) in 2020 compared to estimates in 2003. Despite the changes in the catch, effort, and value estimated for the gleaning fishery in the island since 2003, locals continue to supplement their household incomes through gleaning. Nonetheless, additional investigations into the reproductive and population biology of the different species may be needed to understand further the dynamics of this fishery and its impacts on the species' ecologies.
Klasifikasi Pengembalian Radar dari Ionosfer Menggunakan SVM, NaÃ¯ve Bayes dan Random Forest
Authors: Aryani Yulia , Wijayanto Arie Wahyu
Published: September 2021

ABSTRAK â€“ Klasifikasi merupakan salah satu topik utama dalam data mining atau machine learning. Klasifikasi adalah suatu pengelompokan data dimana data yang digunakan tersebut mempunyai kelas label atau target. Klasifikasi digunakan untuk mengambil data dan ditempatkan kedalam kelompok tertentu.  Studi tentang ionosfer penting untuk penelitian di berbagai domain, khususnya dalam sistem komunikasi.  Dalam penelitian ionosfer, perlu dilakukan klasifikasi radar yang berguna dan tidak berguna dari ionosfer. Pada makalah ini, akan dilakukan klasifikasi  terhadap data inosphere yang diambil dari UCI machine learning repository.  Klasifikasi dilakukan dengan menggunakan tiga metode klasifikasi, yakni  SVM ( Support Vector Machine ) , NaÃ¯ve Bayes, dan Random Forest. Hasil dari percobaan ini bisa menunjukkan prediksi dari setiap percobaan dengan tingkat akurasi dan prediksi yang berbeda-beda di setiap metode yang digunakan. Hasil akurasi, presisi, dan recall terbaik didapatkan pada metode Random Forest dengan rasio data latih dan data uji sebesar 85% didapat akurasi dari data uji sebesar 90,57% dengan presisi sebesar 94,12%.

Kata Kunci â€“ Ionosfer; Klasifikasi; SVM; NaÃ¯ve Bayes; Random Forest.
Klasifikasi Buah Zaitun Menggunakan Convolution Neural Network
Authors: Dwi Antoko Toton , Azhar Ridani Muhammad , Eko Minarno Agus
Published: September 2021

Buah zaitun merupakan tanaman produk hortikultura rumpun oleaceae dengan genus Olea yang memiliki berbagai macam jenis dan fitur yang unik. Satu dari sekumpulan species Olea yang ditemukan di wilayah tropis dan subtropis yang menjadikan tanaman subur dan melimpah. Hasil panen yang sangat melimpah sebanding dengan kebutuhan pasar. Pemanenan produk secara acak membuat pemilihan produk pasca panen sangat penting dalam mengelompokkan jenis buah zaitun. Sehingga perlu adanya sistem yang dapat mengklasifikasi secara otomatis. Sebelumnya sudah ada penelitian yang diusulkan untuk mengklasifikasi buah zaitun dengan akurasi yang cukup tinggi. Namun kecepatan yang diperlukan butuh waktu yang sangat lama karena menggunakan model pretrained yang begitu kompleks. Oleh karena itu, penelitian ini bertujuan untuk melakukan klasifikasi buah zaitun dengan waktu yang lebih cepat dan akurasi yang tidak kalah dari sebelumnya. Metode yang akan digunakan adalah Convolutional Neural Network (CNN) dengan rangkaian arsitektur sendiri. Hasil dari penelitian ini mendapatkan akurasi sebesar 92% dengan 30 epoch.
Perfil nutricional de usuários de terapia nutricional enteral domiciliar
Authors: Prado Moraes Yasmim , Caroline Faria Moreira Daniele , Caroline de Souza Ágatta , Ribeiro Vieira Marques Camilla
Published: September 2021

Introdução: A terapia nutricional enteral domiciliar (TNED) tem como finalidade realizar a manutenção e/ou recuperação do estado nutricional do paciente, trazer benefícios de convívio familiar e social, reduzir riscos de infecções hospitalares e custos com internações. Objetivo: Avaliar o perfil nutricional, socioeconômico e demográfico de pacientes em TNED no município de Varginha-MG que são acompanhados pelas equipes de atenção básica do Sistema Único de Saúde, além de identificar o perfil clínico do usuário. Materiais e Métodos: Foi utilizado a avaliação nutricional subjetiva global (ANSG) para coletar informações sobre o estado nutricional. Medidas antropométricas como circunferência do braço, circunferência da panturrilha, altura do joelho e dobra cutânea tricipital foram aferidas e realizadas as estimativas de peso e estatura. Utilizou-se também questionários para avaliar a história clínica e patológica do paciente e em relação ao tipo de nutrição enteral ofertada e perfil socioeconômico. Para a análise estatística, realizou-se o teste de correlação de Pearson, por meio do software SPSS versão 20.0. Resultados: Constatou-se que 68,1% dos pacientes estavam bem nutridos, 40,9% eram pertencentes a classe socioeconômica C e as doenças de base mais prevalentes que levaram ao uso da terapia foram as neurológicas. A via de acesso predominante foi a gastrostomia com 59,1%, a principal dieta utilizada é a industrializada e o tempo médio de uso da TNED entre os entrevistados foi de 3 anos e 6 meses. Não foram identificadas correlações com o estado nutricional. Conclusão: Os pacientes em TNED no município de Varginha - MG utilizam, predominantemente, dietas industrializadas via gastrostomia. Não foi identificado edemas e/ou estresse metabólico pelo exame físico realizado pela ANSG, caracterizando bom estado nutricional dos avaliados. A maioria dos avaliados pertencem a classe socioeconômica C.
Religião, Decolonialidade e o Princípio Pluralista
Authors: De Oliveira Ribeiro Claudio
Published: September 2021

O texto apresenta os resultados da pesquisa cujo objetivo é analisar a relação entre o pensamento decolonial, os estudos de religião e o princípio pluralista. Metodologicamente, a pesquisa está centrada na formulação de sínteses relativas ao pensamento decolonial, com o recurso de fontes diversificadas, mas com determinado recorte teórico comum, especialmente a noção de “entre-lugar” e de fronteiras, associada às tensões entre as sociologias das ausências e das emergências de identidades e às críticas às formas de colonialidade do poder, do saber e do ser. Tais fontes correspondem também a algumas das principais bases conceituais do princípio pluralista. Neste sentido, há uma circularidade na apresentação destas duas perspectivas, mediada pela preocupação com as implicações da visão decolonial para os estudos de religião. Entre os resultados da pesquisa estão as descrições de algumas tarefas decoloniais: (i) a crítica à visão de um pensamento único, (ii) a revisão da perspectiva de “centrocentrismos”, (iii) o questionamento da visão de universalismo das ciências e da ética, (iv) a análise crítica da supremacia da racionalidade formal técnico-científica moderna e uma avaliação criteriosa da forma meramente conceitual da produção do conhecimento, (v) a revisão da noção de indivíduo desprovida da interação constituinte do humano com a comunidade, a história, a natureza e o cosmo, e (vi) o exame da ideologia das identidades rígidas e fixas.
OS CEMITÉRIOS COMO ESPAÇO DE SEGREGAÇÃO SOCIOESPACIAL: O CASO DO SÃO JOÃO BATISTA (RJ).
Authors: Dos Santos Minhava Marques da Silva Mariana , Vasques da Rocha João Paulo
Published: September 2021

Resumo

Este trabalho visa demonstrar a segregação socioespacial que ocorre nos cemitérios, partindo de uma análise histórica do estabelecimento das primeiras necrópoles no Rio de Janeiro, até os dias de hoje, tendo o cemitério São João Batista como objeto de estudo. Analisando o espaço urbano e o local de análise, há uma clara divisão entre classes, o que ocorre de forma menos dinâmica, obviamente, mas nem por isso menos clara. Através de símbolos, localização e tipo de sepultura, há uma identificação da classe social a qual a pessoa pertencia e ainda há uma separação no cemitério entre sepulturas de maior valor e as de menor valor, assim como nas grandes cidades. Além de espaços óbvios e dinâmicos onde acontece a segregação, como favelas e condomínios fechados, o trabalho visa mostrar esse tipo de processo, que tem suas particularidades, mas nem por isso deixa de demonstrar características da segregação tradicional, estudada por grandes geógrafos.

Palavras-chave: Cemitério São João Batista, Geografia Urbana, Geografia Histórica, Segregação Socioespacial, Espaço Urbano.
ANÁLISE DOS SIGNIFICADOS POLÍTICO-IDENTITÁRIOS DOS MONUMENTOS NA PRAÇA DOS GIRASSÓIS, EM PALMAS, TO
Authors: Lima Wesley , Bessa Kelly
Published: September 2021

Este artigo tem como objetivo identificar os significados políticos-identitários dos principais monumentos edificados na Praça dos Girassóis em Palmas - TO, bem como analisar as intenções e os sentidos desses monumentos no período em que foram instalados. Para tanto, com o suporte de dados documentais, pesquisa em campo e revisão bibliográfica da literatura sobre o tema, tem-se, no primeiro momento, uma descrição detalhada da localização, do ano de implantação e da dimensão espacial desses monumentos; já no segundo momento, elabora-se uma análise reflexiva acerca dos significados atribuídos a essas obras, destacando sua plurivocalidade e a construção desse espaço simbólico para o devir da cidade e dos sujeitos que a ocupam. Os resultados da análise mostram que os monumentos da Praça dos Girassóis foram todos construídos durante a gestão governamental de José Wilson Siqueira Campos, e conclui que estas formas simbólicas espaciais expressam a construção de uma memória para o futuro, associada à imagem do primeiro governador do estado, além de serem portadoras de simbolismos e de autorrepresentação ou autoafirmação política.
CIRCULAÇÃO ÁRABE DO MEDIEVO
Authors: Natanael Domingos Lopes Jahan
Published: September 2021

Na perspectiva decolonial, teceu-se um estudo acerca da circulação árabe do medievo, fundamentando-se pelo conceito dardeliano de geograficidade, o modo de ser geográfico. Configura-se, nisso, um Espaço árabe para situar a dinâmica de circulação, caracteriza-se, pois, por possuir fluxos de grandes riquezas, pelo circuito do ouro sudanês, e de conhecimentos, pelo circuito de trocas técnicas como a arte papeleira, importada dos chineses, tornando possível a produção literária, abrindo a sabedoria em uma difusão tanto espacialmente como temporalmente. Ainda, em sua grande extensão territorial, marca-se pela língua comum, o árabe, e a hegemônica da religião, muçulmana. Nesse horizonte, tem-se situada, a circulação humana, em duas aberturas: a primeira, enquanto formativo-educacional e a segunda, enquanto articulador social. No primeiro ponto, levantou-se a questão da práxis na educação, pois muitos viajantes acompanhavam seus mestres por longos períodos até estarem aptos a serem educadores, o que resultava em uma concentração de certificados de vários mestres em uma jurisdição educacional muito peculiar. O segundo ponto refere-se às questões sociais: primeiro, entende-se que havia benefícios intelectuais – na viagem pelo conhecimento: rihla – e de vivência da fé – pelas viagens religiosas: hijra, hajj e ziyarat – aos viajantes e, inclusive, às famílias que, por toda espacialidade árabe, recebiam fraternamente esses viajantes assentando o reconhecimento de sua simpatia; segundo, havia desafios nas viagens como: guerras, falta de saneamento, carência de água, feras... a rispidez dos citadinos, pela imoralidade, soberba, luxúria... assim, pois, na completude da circulação econômica, epistêmica e humana se dava tanto benesses quanto desventuras. Com base nisso, prospectou-se um trabalho aberto a uma perspectiva da geograficidade decolonial, a fim de se construir um mundo diverso, em uma complexidade própria e autônoma.
Os deuses dançam no Quilombo dos Palmares
Authors: De Lima Silva Rafael , Lopes José Lidemberg de Souza
Published: September 2021

Os estudos sobre o fenômeno religioso têm sido relevantes para compreender esferas entrelaçadas ao sagrado, tais como: economia, política e cultura. A apropriação dos espaços faz parte de um ethos construído e modelado por uma gama de discursos que são oriundos do transcendente, ou como muitos preferem, do espaço sagrado. Nosso artigo tem como objetivo a efetivação de uma hermenêutica do sagrado, tanto em termos descritivos como normativos, instrumentalizada para compreender o eixo da religião de matriz africana no evento anual na Serra da Barriga, no município de União dos Palmares – AL. Como fundamentos metodológicos, utilizamos a junção das teorias geográficas locacional e epistemológica, de Zeny Rosendahl (2018) e Gil Filho (2008), bem como outros nomes na Ciência e História das Religiões, e também na Teologia. Culminando na pesquisa dos anos 2017, 2018 e 2019.
Marsílio Ficino sobre o daemon socrático em seu comentário à Apologia de Sócrates
Authors: Santana Vieira Otávio
Published: September 2021

Este artigo busca compreender a concepção de Marsílio Ficino acerca do caso do daemon socrático em seu comentário à Apologia de Sócrates de Platão. O argumento de Ficino sobre o daemon socrático fundamenta-se na agência demoníaca sobre a mente humana. Neste sentido, analisamos seu comentário buscando clarificar suas ideias, noções e suas fontes médio-platônicas e neoplatônicas. Afirmamos que Ficino ao argumentar acerca do daemon pessoal produz um argumento demonológico com associações à noção de furor divino, principalmente o furor profético. Além disso, Ficino defende a noção do daemon enquanto mediador, guia e destino que se aproxima de sua magia natural apresentada no De Vita.
Budismo e natureza
Authors: Arruda Felipe
Published: September 2021

Os ensinamentos budistas são tradicionalmente divididos em três grandes classes, comumente conhecidas como os “Três Giros da Roda do Dharma” (Tib. chos kyi ‘khor lo bskor gsum), constituindo-se como caminhos espirituais distintos, denominados “veículos” (Skt. yāna, Tib. theg). O presente artigo tem como objetivo investigar as perspectivas específicas destes três veículos acerca da natureza, suas singularidades e atribuições, assim como uma possível complementaridade entre as abordagens dos mesmos.
religiões de matriz africana no Brasil: luta, resistência e sobrevivência
Authors: Paulo Franco Gilciana
Published: September 2021

Resumo: O presente trabalho tem como objetivo discutir os reflexos da colonização na vida dos afro-brasileiros em especial aqueles que são praticantes das religiões de matriz africana. A violência seja ela física simbólica ou psíquica sempre esteve presente no cotidiano dos africanos e seus descendentes aqui no Brasil. Os africanos arrancados do seu continente desde o princípio tiveram que encontrar estratégias que lhes possibilitasse a sobrevivência. E foi na religião, no culto aos orixás que os escravizados encontraram forças sobreviver às brutalidades impostas pelo sistema escravista. Submetidos a um contexto pautado na visão eurocêntrica de enxergar o mundo, os praticantes das religiões de matriz africana desde sempre precisaram lutar contra o racismo e a intolerância para preservar e ressignificar as suas crenças no solo brasileiro
The Hotel Chefs Perception on Traditional Kitchen Culture and Gastronationalism
Authors: Pekersen Yeliz
Published: September 2021

Gastronationalism is a phenomenon that supports the preservation of traditional culinary cultures of societies, revealing the level of awareness and awareness about the national cuisine of the people and preserving these values. Through to the preservation of the culinary culture, which is a reflection of the social structure, the sustainability of these values will be ensured and accurately transferred to future generations. In this context, gastronationalistic identities of the chefs are important for the development of culinary culture. In this direction, a questionnaire has been applied to hotel chefs in January and February 2019 by sampling method. As a result of the study, it has been found out that the traditional perception of culinary culture of the chefs affects the perception levels of gastronationalism and that they have enough theoretical knowledge about local and Turkish dishes.In order to make gastronationalism more effective and sustainable, it is important that chefs working in tourism businesses put the authentic features of the local cuisine to the forefront further and the chefs are encouraged and supported in terms of researching the local cuisine.

 Key words: Gastronationalism; Culture; Traditional Culinary; Hotel; Chef.