bluuebunny/crossref_metadata_2025 huggingface dataset:
Body Mass Index Is Related to the Recovery After Intra-articular Injection of Triamcinolone Acetonide for the Treatment of Frozen Shoulder: Case Series Study
Authors: Kim Yang-Soo , Kim Bo-Seoung , Lee Hyo-Jin
Published: June 2021

Background: Patients with frozen shoulder tend to respond differently to the intra-articular injection of triamcinolone acetonide. The purpose of the present study was to evaluate the clinical effect of glenohumeral injection with triamcinolone acetonide for frozen shoulder and determine the factors related to extent of range of motion (ROM) recovery.Methods: A cohort of patients who underwent intra-articular glenohumeral injection of triamcinolone acetonide under diagnosis of primary frozen shoulder was reviewed. The primary outcome variable of interest was the range of changes in each aspect of ROM at six weeks after injection. The relationship between improvement and unresponsiveness to intra-articular injection for the treatment of frozen shoulder with various factors were evaluated. The analyzed factors were as follows: age, sex, body mass index (BMI), initial ROM before injection, symptom duration, hand dominance, smoking history, and the existence of underlying disease including diabetes mellitus, hypertension, coronary disase, thyroid disease and hypercholesterolemia.Results: A total of 305 patients were reviewed. There were significant improvements in all aspects of ROM at six weeks after injection. The forward flexion (ρ=-0.346, p<0.001) and external rotation (ρ=-0.204, p=0.040) showed a negative correlation with BMI. Multivariate analysis revealed that BMI is the sole factor related to recovery of forward flexion (p=0.032) and external rotation (p=0.007) at six weeks post-injection. Conclusion: Intra-articular injection of triamcinolone acetonide is an effective method for improving ROM in patients with frozen shoulder. Increased BMI showed adverse effects on ROM recovery.
Immune Alveolitis in Interstitial Lung Disease: an Attractive Cytological Profile in Immunocompromised Patients.
Authors: Moui Antoine , Dirou Stéphanie , Sagan Christine , Liberge Renan , Defrance Claire , Arrigoni Pierre-Paul , Morla Olivier , Kandel-Aznar Christine , Cellerin Laurent , Cavailles Arnaud , Eschapasse Emmanuel , Morio Florent , Gourraud Pierre-Antoine , Goronflot Thomas , Tissot Adrien , Blanc François-Xavier
Published: June 2021

Background: Bronchoalveolar lavage (BAL) is a major diagnostic tool in interstitial lung disease (ILD). Its use remains largely quantitative, usually focused on cell differential ratio. However, cellular morphological features provide additional valuable information. The significance of the "immune alveolitis" cytological profile, characterized by lymphocytic alveolitis with activated lymphocytes and macrophages in epithelioid transformation or foamy macrophages desquamating in cohesive clusters with lymphocytes, remains unknown in ILD. Our objective was to describe patients’ characteristics and diagnoses associated with an immune alveolitis profile in undiagnosed ILD.Methods: We performed a monocentric retrospective observational study. Eligible patients were adults undergoing diagnostic exploration for ILD and whose BAL fluid displayed an immune alveolitis profile. For each patient, we collected clinical, radiological and biological findings as well as the final etiology of ILD. Results: Between January 2012 and December 2018, 249 patients were included. Mean age was 57±16 years, 140 patients (56%) were men, and 65% of patients were immunocompromised. The main etiological diagnosis was Pneumocystis pneumonia (PCP) (24%), followed by drug-induced lung disease (DILD) (20%), viral pneumonia (14%) and hypersensitivity pneumonitis (HP) (10%). All PCP were diagnosed in immunocompromised patients while HP was found in only 8% of this subgroup. DILD and viral pneumonia were also commonly diagnosed in immunocompromised patients (94% and 80%, respectively).Conclusions: Our study highlights the additional value of BAL qualitative description in ILD. We suggest incorporating the immune alveolitis profile for the diagnosis and management of ILD, especially in immunocompromised patients, since it guides towards specific diagnoses.
Universal Health Coverage and The Pacific Islands: Challenges Faced and Priority Responses, 2015-2020
Authors: Craig Adam T , Beek Kristen , Gilbert Katherine , Suakai Taniela Sunia , Liaw Siaw-Teng , Hall John
Published: June 2021

Background
In 1995, Pacific Health Ministers articulated their vision of a healthy Pacific as ‘a place where children are nurtured in body and mind; environments invite learning and leisure; people work and age with dignity; where ecological balance is a source of pride; and where the ocean is protected.’ Central to this vision is the achievement of universal health coverage (UHC).
Method:
To shed light on the current UHC-related priorities of Pacific health authorities and promote alignment of domestic and international investments in health sector development, we thematically analyzed the discussion, resolutions, and recommendations from 5-years (2015–2020) of senior-level Pacific health meetings.
Results
Five main themes emerged, (i) the Healthy Islands vision has (and continues to have) a unifying influence on action for UHC; (ii) adoption of appropriate service delivery models that support integrated primary health care at the community level are needed; (iii) human resources for health are critical if efforts to achieve UHC are to be successful; (iv) access to reliable health information is core to health sector improvement; and (v) while not a panacea for all challenges, digital health offers many opportunities. Small and isolated populations, chronic workforce limitations, weak governance arrangements, aging and inadequate health facilities, and supply chain and logistics difficulties (among other issues) interact to challenge primary health care delivery across the Pacific islands.
Conclusion
We found evidence that the Healthy Islands vision is a tool that garners support for UHC; however, to realize the vision, a realistic understanding of needed political, human resource, and economic investments is required. The significant disruptive effect of COVID-19 and the uncertainty it brings for implementation of the medium- to long-term health development agenda raises concern that progress may stagnate or retreat.
Acylsugars Protect Nicotiana Benthamiana Against Insect Herbivory and Desiccation
Authors: Feng Honglin , Acosta-Gamboa Lucia , Kruse Lars H , Tracy Jake D , Chung Seung Ho , Fereira Alba Ruth Nava , Shakir Sara , Xu Hongxing , Sunter Garry , Gore Michael A , Casteel Clare L , Moghe Gaurav D. , Jander Georg
Published: June 2021

Nicotiana benthamiana is used extensively as a transient expression platform for functional analysis of genes from other species. Acylsugars, which are produced in the trichomes, are a hypothesized cause of the relatively high insect resistance that is observed in N. benthamiana. We characterized the N. benthamiana acylsugar profile, bioinformatically identified two acylsugar acyltransferase genes, ASAT1 and ASAT2, and used CRISPR/Cas9 mutagenesis to produce acylsugar-deficient plants for investigation of insect resistance and foliar water loss. Whereas asat1 mutations reduced accumulation, asat2 mutations causedalmost complete depletion of foliar acylsucroses. Three hemipteran and three lepidopteran herbivores survived, gained weight, and/or reproduced significantly better on asat2 mutants than on wildtype N. benthamiana . Both asat1 and asat2 mutations reduced the water content and increased leaf temperature. Our results demonstrate the specific function of two ASAT proteins in N. benthamiana acylsugar biosynthesis, insect resistance, and desiccation tolerance. The improved growth of aphids and whiteflies on asat2 mutants will facilitate the use of N. benthamiana as a transient expression platform for the functional analysis of insect effectors and resistance genes from other plant species. Similarly, the absence of acylsugars in asat2 mutants will enable analysis of acylsugar biosynthesis genes from other Solanaceae by transient expression.
National Rare Diseases Registry System (NRDRS) – China’s First Nation-Wide Rare Diseases Demographic Analyses
Authors: Guo Jian , Liu Peng , Chen Limeng , Lv Haohan , Li Jie , Yu Weichao , Xu Kaifeng , Zhu Yicheng , Wu Zhihong , Tian Zhuang , Jin Ye , Yang Rachel , Gu Weihong , Zhang Shuyang
Published: June 2021

China has made remarkable broad and system wide progress in serving the needs of its people living with rare diseases, especially over the last 5 years. The Chinese government’s systematic approach included a series of coordinated initiatives, amongst these are: forming the Rare Disease Expert Committee (2016), to funding the “Rare Diseases Cohort Study” (2016–2020), and to publishing its first “Rare Disease Catalog” (2018). Herein, we present the National Rare Diseases Registry System (NRDRS), China’s first national rare diseases registry, and analysis of the cases registered in the first 5 years ending Dec 31, 2020. The total 62,590 cases covered 166 diseases/disease types, forming 183 disease cohorts. The data from nearly 22% of them (13,947 cases) is also linked to valuable biological samples. The average age of definitive diagnosis was 30.88 years; 36.07% under 18 years of age. Regional distribution analysis showed 60% of cases were from the more developed East and North China, suggesting the local availability of quality care and patients’ financial status were key access factors. Finally, 82.04% of cases were registered from the five clinical departments: Neurology, Endocrine, Hematology, Cardiovascular, and Nephrology, suggesting that either these are most affected by rare diseases, or that there were disease non-specific ascertainment factors. The preliminary analysis of the first 5-year’s data provides unique and valuable insight on rare disease distribution in China, and higlights directions for enhancing equity, scale and utility.
Which Sagittal Evaluation System Can Effectively Predict Mechanical Complications in the Treatment of Elderly Patients With Adult Degenerative Scoliosis? Roussouly Classification or Global Alignment and Proportion (GAP) Score
Authors: Sun Xiangyao , Sun Wenzhi , Sun Siyuan , Hu Hailiang , Zhang Sitao , Kong Chao , Lu Shibao
Published: June 2021

Background: To achieve the proper sagittal alignment, previous studies have developed different assessment systems for degenerative spinal deformity which could help us in making treatment strategies. The purpose of our study is to evaluate whether Roussouly classification or GAP score is more appropriate in the prediction of mechanical complications after surgical treatment of ADS.Methods: The ADS patients who received long segmental fusion in the treatment during the period from December 2016 to December 2018 were evaluated in this study. The basic information of the patients and all radiologic measurements, which were included in GAP score and Roussouly classification, were collected for analysis. Patients were divided into two groups according to occurrence or absence of mechanical complications for comparison. The correlation between evaluation systems and mechanical complications could be analyzed in logistic regression model via stepwise backward elimination based on the Wald statistics. ROC curve was used to determine the predictability of the evaluation systems in the occurrence of mechanical complications and calculate their cut-off value. A two-tailed P value < 0.05 was statistically significant for all statistical tests.Results: A total of 80 cases were included in this study. The results of logistic regression showed: GAP score (P = 0.008) and GAP categories (P = 0.007) were positively correlated with mechanical complications; Roussouly score was negatively correlated with mechanical complications (P=0.034); GAP score was positively correlated with PJK (P = 0.021); Roussouly score was negatively correlated with implant-related complications (P = 0.018); GAP categories were correlated with implant loosening (P = 0.023). Results of ROC showed that GAP score was most effective in predicting PJK (AUC = 0.863) and PJF (AUC = 0.724); GAP categories (AUC = 0.561) was more effective than GAP score (AUC = 0.555) in predicting implant-related complications.Conclusions: Roussouly-type matching could not accurately predict the risk of mechanical complications. In contrast, GAP score was most effective in predicting PJK and PJF. The GAP score was better than Roussouly classification in predicting mechanical complications.
Transcriptome Profiling Revealed Candidate Genes, Pathways and Transcription Factors Related to Nitrogen Utilization and Excessive Nitrogen Stress in Perennial Ryegrass
Authors: Li Yinruizhi , Wang Mengdi , Teng Ke , Dong Di , Liu Zhuocheng , Zhang Tiejun , Han Liebao
Published: June 2021

Ryegrass (Lolium perenne L.) is a type of the high quality forage grasses, which can be a good nutritional source for herbivorous livestock. However, improving the nitrogen utilization efficiency and avoiding the nitrate toxicity caused by excessive nitrogen have long been the challenging tasks in ryegrass. The molecular response mechanism of ryegrass to nitrogen, especially under the condition of excessive nitrogen, remains unclear. In this study, the transcription of perennial ryegrass at different nitrogen levels was identified by high-throughput next-generation RNA sequencing. Phenotypic characterizations showed that ryegrass in treatment N0.5 had a better growth state than the other three groups. Treatments N1 and N10 contained excessive nitrogen, which had a stress effect on plant growth. Analysis of differentially expressed genes indicated that 345 and 104 genes are involved in the regulation of nitrogen utilization and excessive nitrogen stress, respectively. GO enrichment analysis revealed that the plant response to nitrogen was mainly enriched in two categories, including “biological process” and “molecular function”. KEGG enrichment analysis suggested that “Photosynthesis-antenna proteins” may respond positively to nitrogen under appropriate nitrogen conditions, whereas “steroid biosynthesis”, “carotenoid biosynthesis” and “C5-branched dibasic acid metabolism” were identified as the top significantly enriched pathways in response to excessive nitrogen. Transcription factor analysis showed that 21 TFs related to nitrogen utilization were classified into 10 transcription factor families, especially the AP2-EREBP and MYB TF families. Four TFs related to excessive nitrogen stress were identified, including LOB, NAC, AP2-EREBP and HB. The expression patterns of these selected genes were also analyzed.
The Potential Utility of 68Ga-FAPI-04 As a Novel Broad-spectrum Tumor and Inflammatory Imaging Agent - Comparison With 18F-FDG
Authors: Qiu Lin , Lan Lianjun , Liu Hanxiang , Wang Yingwei , Deng Jia , Peng Dengsai , Feng Yue , Wang Li , Chen Yue
Published: June 2021

Objective: This study aimed to compare the diagnostic performance of 68Ga-FAPI-04 and 18F-FDG PET/CT in the patients with various oncological and non-oncological lesions. Patients and Methods: A total of 123 patients underwent contemporaneous 68Ga-FAPI-04 and 18F-FDG PET/CT were included in this prospective study. The maximum standard uptake value (SUVmax) was measured to compare oncological and non-oncological lesion uptake. The sensitivity, specificity, predictive values and accuracy of 18F-FDG and 68Ga-FAPI-04 PET/CT for detecting primary, metastatic, and non-oncological lesions were calculated and compared to evaluate the diagnostic efficacy. Results: The study subjects consisted of 123 patients (69 men and 54 women; mean age: 56.11±11.94). A total of 84 patients with 88 solid primary malignant tumors, 58 patients with 376 nodal metastases, 43 patients with 406 distant metastases, 8 patients with hematological neoplasms and 52 patients with 145 non-oncological lesions and benign tumors were detected. 68Ga-FAPI-04 PET/CT demonstrated a significantly higher uptake and detection rate for the primary (SUVmax: 10.98±5.83 vs. 8.36±6.43, p＜0.001; X2=0.538, p=0.021), nodal (SUVmax: 10.50±5.98 vs. 8.20±6.29, p=0.011; X2=2.067, p＜0.001) and distant metastatic lesions (SUVmax: 6.74±4.83 vs. 9.64±6.45; p＜0.001; X2=4.897, p＜0.001) of solid tumor than did 18F-FDG PET/CT. 68Ga-FAPI-04 PET/CT demonstrated a lower activity (SUVmax: 6.84±4.67 vs. 13.09±7.29, p＜0.001) and detection rate (X2=5.166, p＜0.001) for multiple myeloma and lymphoma compared to 18F-FDG PET/CT. 68Ga-FAPI-04 and 18F-FDG PET/CT PET/CT demonstrated a comparative diagnostic efficacy (SUVmax: 6.40±3.95 vs. 5.74±15.78, p = 0.729; X2 = 9.460, p = 0.007) for non-oncological lesion and benign tumor detection. Conclusions: Except for myeloma and lymphoma, 68Ga-FAPI-04 PET/CT showed a superior diagnostic efficacy for detecting various primary and metastatic lesions than 18F-FDG PET/CT. A comparative diagnostic utility for non-oncological lesion detection was obtained with both tracers. 68Ga-FAPI-04 could be used as a broad-spectrum tumor and inflammatory imaging agent in the clinical especially for various solid tumors and non-oncological lesions.
Coral and Seawater Metagenomes Reveal Key Microbial Functions to Coral Health and Ecosystem Functioning Shaped at Reef Scale
Authors: Lima Laís Farias Oliveira , Alker Amanda , Papudeshi Bhavya , Morris Megan , Edwards Robert , de Putron Samantha , Dinsdale Elizabeth
Published: June 2021

Background The coral holobiont is comprised of a highly diverse microbial community that provides key services to corals such as protection against pathogens and nutrient cycling. The coral surface mucus layer (SML) microbiome is very sensitive to external changes and tied to ecosystem functioning, as it constitutes the direct interface between the coral host and the environment. The functional profile of microbial genes in the coral SML is underexplored and the use of shotgun metagenomics is relatively rare among coral microbiome studies. Here we investigate whether the bacterial taxonomic and functional profiles in the coral SML are shaped by the local reef zone and explore their role in coral health and ecosystem functioning. Results The analysis was conducted using metagenomes and metagenome assemble genomes (MAGs) associated with the coral Pseudodiploria strigosa and the water column from two naturally distinct reef environments in Bermuda: inner patch reefs exposed to a fluctuating thermal regime and the more stable outer reefs . Our results showed that the microbial community structure is simultaneously selected by the host medium (i.e., coral SML versus water) and the local environment (i.e., inner reefs versus outer reefs), both at taxonomic and functional levels. The coral SML microbiome from inner reefs provides more gene functions that are involved in nutrient cycling (e.g., photosynthesis, phosphorus metabolism, sulfur assimilation) and that are related to higher levels of microbial activity, competition, and stress response, such as dimethylsulfoniopropionate (DMSP) breakdown. In contrast, the coral SML microbiome from outer reefs contained genes indicative of a carbohydrate-rich mucus composition found in corals exposed to less stressful temperatures and showed high proportions of microbial gene functions that play a potential role in coral disease, such as degradation of lignin-derived compounds and sulfur oxidation. Conclusion The fluctuating environment in the inner patch reefs of Bermuda could be driving a more beneficial coral SML microbiome; potentially increasing holobiont resilience to environmental changes and disease. Our results reveal microbial taxa and functions selected at reef scale in the coral SML microbiome that can leverage disease management, microbiome engineering, and microbial eco-evolutionary theories.
Community Perception and Acceptance of Patients with Prosthetic Devices after Disabilities in Riyadh, Saudi Arabia
Authors: Alhumaidan Mohammed Ibrahim , Juhani Wazzan S. Al , Hussaini Abdulmohsen A. Al , Angari Hussam S. Al , Jabr Saad Z. Al , Karni Abdullah F. Al
Published: June 2021

The authors have requested that this preprint be removed from Research Square.
Dynamic resource management algorithms for interference prediction in 5G new radio scenarios
Authors: ANGRI Ismail , Mahfoudi Mohammed , Najid Abdellah
Published: June 2021

Efficient Radio Resource Management is a key mechanism in interference management in 5G New Radio (NR) networks, specifically in the case of the presence of mobile users moving at high speed. To this end, the prediction and the evaluation of the propagation channel sensitivity requires that the radio resources allocation in NR must be efficient and powerful. Therefore, several scheduling algorithms have been developed and tested using the mmWave model of NS-3 simulator, with the aim of enhancing their contribution to improving the quality of the signal received by users. The performances have been evaluated in terms of Signal-to-Interference-and-Noise-Ratio (SINR) and signal Block Error Rate (BLER). The simulations were run for different types of data flows, and achieved satisfactory results for most schemes. The achievements clearly show the importance of scheduling algorithms in lowering received interference, but they have also demonstrated the stability and reliability of some of those strategies.
Development and Validation of Interpretable Machine Learning for Stroke Occurrence in Older, Community Chinese Dwellers
Authors: Wu Yafei , Jiang Zhongquan , Lin Shaowu , Fang Ya
Published: June 2021

Background: Prediction of stroke based on individuals’ risk factors, especially for a first stroke event, is of great significance for primary prevention of high-risk populations. Our study aimed to investigate the applicability of interpretable machine learning for predicting a 2-year stroke occurrence in older adults compared with logistic regression.Methods: A total of 5960 participants consecutively surveyed from July 2011 to August 2013 in the China Health and Retirement Longitudinal Study were included for analysis. We constructed a traditional logistic regression (LR) and two machine learning methods, namely random forest (RF) and extreme gradient boosting (XGBoost), to distinguish stroke occurrence versus non-stroke occurrence using data on demographics, lifestyle, disease history, and clinical variables. Grid search and 10-fold cross validation were used to tune the hyperparameters. Model performance was assessed by discrimination, calibration, decision curve and predictiveness curve analysis.Results: Among the 5960 participants, 131 (2.20%) of them developed stroke after an average of 2-year follow-up. Our prediction models distinguished stroke occurrence versus non-stroke occurrence with excellent performance. The AUCs of machine learning methods (RF, 0.823[95% CI, 0.759-0.886]; XGBoost, 0.808[95% CI, 0.730-0.886]) were significantly higher than LR (0.718[95% CI, 0.649, 0.787], p<0.05). No significant difference was observed between RF and XGBoost (p>0.05). All prediction models had good calibration results, and the brier score were 0.022 (95% CI, 0.015-0.028) in LR, 0.019 (95% CI, 0.014-0.025) in RF, and 0.020 (95% CI, 0.015-0.026) in XGBoost. XGBoost had much higher net benefits within a wider threshold range in terms of decision curve analysis, and more capable of recognizing high risk individuals in terms of predictiveness curve analysis. A total of eight predictors including gender, waist-to-height ratio, dyslipidemia, glycated hemoglobin, white blood cell count, blood glucose, triglycerides, and low-density lipoprotein cholesterol ranked top 5 in three prediction models.Conclusions: Machine learning methods, especially for XGBoost, had the potential to predict stroke occurrence compared with traditional logistic regression in the older adults.
Complete adherence to antenatal care guideline during the first visit and antepartum complications in public health facilities: a prospective cohort study in Northwest Ethiopia
Authors: Seyoum Tewodros , Alemayehu Mekuriaw , Christensson Kyllike , Lindgren Helena
Published: June 2021

Background

Adherence to a minimum level of recommended content during the first Antenatal care (ANC) is low in Ethiopia but less is known about if there is an association between the level of adherence to focused ANC guideline and pregnancy outcomes. Therefore, the goal of this study was to examine the relationship between the level of adherence to Ethiopian ANC guidelines during the first visit and maternal complications that occur during the antepartum period.
Methods

A prospective cohort study was conducted in Gondar town public health facilities from May, 2019, to January, 2020. A total of 832 pregnant women with gestational age < 28 weeks who came for their first ANC visit were enrolled and followed until their last visit or before the commencement of labor. An 18-point checklist was used to record the level of providers’ adherence. Clients who received all the components in the ANC guideline during the first visit adhered to by the provider were considered as an exposed group. A Log-binomial model was used to examine the relationship between the level of adherence to the guideline and the risk of antenatal complications. The adjusted Relative Risk (ARR) with a 95% Confidence Interval (CI) was reported in the final model.
Result

A total of 808 pregnant women were included in the final analysis. Complete providers’ adherence was associated with a lower risk of anemia (ARR = 0.54; 95% CI: 0.31, 0.94), but with a higher risk for Pregnancy-induced hypertension (ARR = 1.71; 95% CI: 1.04, 2.81).
Conclusions

Complete providers’ adherence to the first ANC guideline influences maternal complications during antepartum period. Therefore, improving the level of adherence by the provider to the ANC guideline during the first visit is very important.
Response To Pre-Operative Corticosteroids Predicts Durable Neurologic Improvement in Patients with Symptomatic Brain Metastases
Authors: Bowden Stephen G , Ramos Christian Lopez , II Barry Cheaney , Richie Emma , Yaghi Nasser K , Munger Daniel N , Wood Matthew D , Cetas Justin S , Dogan Aclan , Raslan Ahmed M , Han Seunggu J
Published: June 2021

Purpose:

To determine the rate at which focal neurologic deficits respond to pre-operative corticosteroids in patients with brain metastases and whether such an improvement is predictive of long-term improvement in neurologic function following surgery.
Methods:

Patients with pathology-proven brain metastases who underwent open surgical resection between 2010 and 2019 were identified. Charts were reviewed to identify patients with deficits in language, visual field, or motor domains who received corticosteroids prior to surgery. Descriptive analysis compared characteristics between steroid responders and non-responders. Dosage and duration were binned into deciles and plotted against their corresponding response rates.
Results:

96 patients demonstrated a visual field (13 patients), language (19), or motor (64) deficit and received dexamethasone in the week prior to surgery (average cumulative dose 42.66 mg; average duration 64.5 hours). 38.5% of patients’ deficits improved on neurologic exam prior to surgery. 82.3% of patients improved by follow-up. Motor deficits were most likely to improve (46.9%; p = 0.024). All 37 responders demonstrated durable improvement at follow-up whereas 42 of 59 (71%) of non-responders ultimately improved (p < 0.001). Average dosage and duration prior to response were 17.33 mg and 23.94 hours, respectively. All other clinical characteristics were similar between responders and non-responders.
Conclusions:

A response to steroids prior to surgery predicts long-term improvement for focal neurologic deficits related to brain metastases. Lack of such a response portends a somewhat less favorable prognosis. There is no obvious association between duration or intensity of therapy and response.
Topological Characteristics Associated with Intraoperative Stimulation Related Epilepsy of Glioma Patients: A DTI Network Study
Authors: Yang Jianing , Zhou Chunyao , Liang Yuchao , Wang Yinyan , Wang Lei
Published: June 2021

Purpose Awake craniotomy with intraoperative stimulation has been utilized in glioma surgical resection to preserve life quality. While 5-20% of cases may occur epilepsy during the procedure which leads to severe consequences. The study aimed to discussing the mechanism of intraoperative stimulation-related epilepsy (ISE) with DTI based graph theoretical analysis.Methods 20 patients with motor-area glioma were enrolled and divided into 2 groups (Ep and nEp) according to whether there was ISE. Additionally, a group of 10 healthy participants matched by age, gender and education year were also involved. All participants underwent T1, T2 and DTI. Graph theoretical analysis was applied to reveal topological characteristics of the white matter networks. Results Three connections were found to be significantly lower in at least one weighting in Ep group. They are the connection between A1/2/3truL and A4ulL, A1/2/3truR and A4tR, and A6mL and A6mR. Global efficiency was found to be significantly decreased while the shortest path length increased in Ep group in at least one weighting. Ten nodes exhibited significant difference in the nodal efficiency and degree centrality analysis. The nodes A6mL and A6mR showed markable decrease in total four weightings in Ep group.Conclusion The hub nodes A6mL and A6mR, get disconnected in the patients with ISE, causing subsequent lower efficiency of global and regional network. The findings provide basis for presurgical assessment of ISE, for that caution should be taken when it involves hub nodes during intraoperative electrical stimulation.
Influences of Intravenous Thrombolysis with Recombinant Tissue-type Plasminogen Activator on the Outcome of Atrial Fibrillation Patients with Acute Ischemic Stroke: A Case a Case-control Study of 227 Patients
Authors: Wang Hai-xia , Zhang Nan , Wang Guo-Qiang , Huang Yong-hua
Published: June 2021

Background: It is a debatable topic about the benefit of intravenous (IV) thrombolysis with recombinant tissue-type plasminogen activator (rt-PA) for atrial fibrillation (AF) patients with acute ischemic stroke (AIS). This study aimed to identify whether IV rt-PA could improve the short-term outcome of patients with AF-AIS.Methods: Medical data of patients with AIS onset within 72hs admitted in the department of neurologic of our hospital between January 1st, 2015 and December 31, 2020 were extracted. The AF-AIS patients were selected and divided into IV rt-PA group (group A) and non-rt-PA group (group B). The baseline characteristics, imaging changes and modified Rankin Scale (mRS) score (≤ 2 as good prognosis, > 2 as poor, = 6 as death) at discharge were obtained to compare the differences between the two groups. Logistic regression was used to analyze the factors influencing on the outcome. Results: Among a total of 1663 AIS patients, there were 280 had AF, of them 227 AF-AIS cases were conformed to the inclusion criteria, including 45 in group A and 182 in group B. All of AF-AIS patients, 48.0% had larger size of infarction and 62.1% had National Institute of Health stroke scale (NIHSS)score more than 10, the differences in the size and NIHSS between the two groups were not significant. A total of 51 cases (22.5%) died during hospitalization, the difference between group A and group B was not obvious (20.0% vs. 23.1%, P=0.658). The cumulative poor outcome (including deaths) at discharge was 75.3%, the difference between the two groups was also not significant (77.8% vs. 74.7%, P=0.671). The incidence of hemorrhagic transformation (HT) in group A was higher than that of in group B (40.0% vs. 21.4, P=0.010), the same was true for parenchymal hematoma (PH) in group A than group B (22.2% vs. 5.5%, P = 0.001). On univariate analysis, poor outcome was significantly associated with infarct size, NIHSS and PH, but not thrombolysis. The proportion of PH in patients with poor outcome between the two groups was also not remarkable. On adjusted multiple logistic regression analysis, both baseline infarction size [(P=0.013, odds ratio (OR) =4.558, 95% 95% confidence interval (CI): 1.373- 15.133] and NIHSS (P<0.001, OR=1.348, 95% CI=1.219-1.491) but not thrombolysis or PH entered into the final model as significant independent risk factors of poor outcome. Conclusion: Patients with AF-AIS had larger infarction size, higher NIHSS score, higher rate of mortality and worse outcome, for them, the IV rt-PA increased the incidence of PH except significantly improved their short-term prognosis.
In silico studies on milk derived peptides as potential inhibitors against SARS CoV-2 spike protein receptor binding domain
Authors: Mukhopadhyay Sutanu , Sarkar Anasua
Published: June 2021

COVID-19 (Corona Virus Infected Diseases-19) is caused by a strain of coronavirus called SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2). There’s no permanent diagnosis available till date to combat the disease. The viral infection in humans is initiated by binding of RBD (receptor binding domain) of spike protein to human angiotensin-converting enzyme 2 (hACE2) receptor protein. In this computational study, milk-derived peptides are screened against Receptor Binding Domain (RBD) of spike protein of the virus. Milk is considered as one of the most nutrient-rich liquid foods having several antibacterial and antiviral activities. Milk derived peptides including Casein and Whey derived peptides are known to have profound anti-viral and immunomodulatory activities. After extensive literature search, some peptides having anti-viral activities against different viruses, are shortlisted for this study and their three-dimensional structures are modelled for protein-peptide docking against SARS-CoV-2 spike protein RBD. After performing protein-peptide docking and protein-protein docking using different servers such as HPEPDOCK, FIREDOCK, HADDOCK, HDOCK, it has been observed that in presence of the peptides, the interaction between spike RBD and hACE2 has been reasonably decreased, which implies that milk-derived peptides can be potential peptide-inhibitors against the RBD of the virus along with other medications. Further studies on milk-derived peptides should be performed to develop peptide drugs based on milk-derived peptides.
Evolution of the Efficiency of Divalent Cobalt and Copper Chelates Based on Isatin Derivatives and Thiosemicarbazide Ligands as Inhibitors for the Corrosion of Sabic Iron in Acidic Medium
Authors: El-Ghamry Hoda A. , Fawzy Ahmed , Farghaly Thoraya A. , Bawazeer Tahani M. , Alqarni Nada , Alkhatib Fatmah M. , Gaber Mohamed
Published: June 2021

Divalent cobalt and copper chelates of the two ligands 1-(1- Ethoxycarbonylmethyl-2-oxoindolin-3-ylidene) thiosemicarbazide (EOIT) and 1-(1-Benzyl-2-oxoindolin-3-ylidene) thiosemicarbazide (BOIT) are the target compounds of the current study. Identification of the constitution and geometry of these compounds have been performed using the possible physicochemical and analytical instruments. Elemental analysis, molar conductance and thermal analysis assured the composition of the four chelates to be [Co(POIT)Cl]•1.5H2O, [Cu(POIT)Cl], [Co(BOIT)Cl2(H2O)]•5H2O and [Cu(BOIT)Cl]•Cl which was further confirmed by the measurement of mass spectra. The architecture arrangement of the ligand atoms around Co and Cu centers has been determined depending on the UV-Vis spectral measurements and calculation of µeff values assuring the copper compounds to be square plane whereas the cobalt complexes have tetrahedral or octahedral arrangements. These compounds were examined as corrosion inhibitors for the Sabic steel in 1.0 M HCl utilizing potentiodynamic polarization, electrochemical impedance spectroscopy, mass-loss method and scanning electron microscopy at fixed temperature of 298 K. The acquired outcomes disclosed that the inhibition efficiencies (% IEs) of the examined compounds were set to be dependent on both the concentrations and composition of the compounds. The examined compounds were set to have high % IEs, which were interpreted by strong adsorption of the compounds’ molecules on the iron surface and such adsorption was discovered to follow Langmuir adsorption isotherm. The investigational results obtained from all utilized techniques were set to be in a good accord with each other.
Diagnosis, prognosis and clinical treatment of refractory atypical chronic lymphocytic leukemia with multiple B cells: A case report.
Authors: Chen Man , Sun Huipeng , Zhang Lina , Gao Haiyan , Fu Minjing , Li Ting , Wang Aixian , Wu Xueying , Zhen Junyi , Gong Meiwei , Du Qing , Wu Ping , Wang Tong , Liu Hongxing , Zhou Xiaoge , Wang Hui
Published: June 2021

Background: Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is the most prevalent adult leukemia, and its incidence continues to rise year after year. Rapid and precise diagnosis is an essential element in effective case management, however, the clinical diagnosis, treatment, and prognosis of CLL/SLL are not fully elucidated. Case presentation: we report the case of a 66-year-old man with atypical CLL/SLL. The white blood cell (WBC) count (842.0 × 109/L), platelet count (30.6 × 109/L), and abnormal lymphocytes were increased in peripheral blood. Flow cytometry showed 98.34% of nucleated cells were malignant monoclonal mature B cell. Peripheral blood smear found the leukocytes and lymphocytes with abnormal morphology were increased. Fluorescence in situ hybridization showed CCND1 (11q23)/IGH (14q32) and abnormal chromosome 12 were invisible, 91%-93% of interphase nuclei presented D13S319 and TP53, 17p13.1 loss. Histopathology analysis of bone marrow observed the proliferation centers with immunoblasts. Immunohistochemistry showed that bone marrow was positive for PAX-5, CD20, CD23, and CD5, negative for CD3, cyclinD1, and sox11, and partial positive for Ki67. The patient was diagnosed as CLL/SLL based on above clinical and laboratory findings. The patient was managed with oral 50 mg Vinetoc, fluid replacement, hydration and alkalinization, and the symptoms were significantly relieved. Conclusions: This report further expands the knowledge of clinical diagnosis and treatment of atypical CLL/SLL.
Housing situation, residential Relationship and the prevention of chronic diseases of the elderly
Authors: Yajun Duan , Juan Luo
Published: June 2021

Background:To understand the impact of housing and living-related factors on the chronic diseases of the elderly floating population, and to provide preventive measures for reducing the risk of chronic diseases among the elderly floating population in my country. Methods:In this paper, we used the data from the 2017 Migrant Population Dynamic Monitoring Survey in China, selected housing and housing-related factors as explanatory variables, and adopted a binary logistic regression analysis method. Result:People living in free housing are more mobile and more susceptible to chronic diseases; most people in self-owned housing need to repay their mortgages in their daily lives, and there is a certain life pressure that affects them to enjoy a high-quality life; elderly floating population who migrate with spouses or children Life pressure is heavier, and there is a greater probability of chronic disease risk. Conclusion:This article proposes that all localities should strictly control housing prices, increase housing supply for the floating population, improve the service level of the elderly floating population, improve the social security system and mechanisms, and effectively improve the happiness of the elderly floating population.
INTERRATER AND INTRARATER RELIABILITY OF PRESSURE BIOFEEDBACK UNIT IN MEASUREMENT OF TRANSVERSES ABDOMINIS MUSCLE ACTIVATION IN ASYMPTOMATIC ADULTS
Authors:   PhD Scholar in Gujarat University, I/C Lecturer, Government Spine Institute and Physiotherapy College, Ahmedabad, India., Vallabhbhai Solanki Disha , Soni Neela ,   Ph. D. Guide in Gujarat University and Academic Director, SKUM College of Physiotherapy, Ahmedabad, India.
Published: June 2021

Background â€“The Transverse abdominis with its direct attachments to lumber vertebrae through thoracolumber fascia contributes as a local stabilizer of spine which have meaningful role for spinal stability. Transverse abdominis(TrA) activation is vital component in rehabilition of patients with Low back pain. The Pressure Biofeedback Unit (PBU) is a device designed to teach and measure Transverses abdominis activation by Abdominal draw-in maneuver which is often used by clinicians. Methods â€“ 60 healthy male and female subjects were selected for study. The abdominal draw-in test was performed with the subject in a prone lying position, and the Pressure Biofeedback Unit (Chattanooga Stabilizer ) was utilized to evaluate the ability of the subject to perform this abdominal isolation test. For intrarater reliability, the examiner carried out the test twice at the interval of 2 days. For interrater reliability, 2 examiners did the test one after the other on the same day. Results â€“ Intraclass Correlation Coefficient (ICC) were calculated to determine interrater and intrarater reliability.ICC value for inter-rater reliability is 0.87 with 95% confidence interval (0.78-0.92). ICC value for intra-rater reliability is 0.86 with 95% confidence interval (0.79 â€“ 0.93). Conclusion - Pressure Biofeedback Unit shows good to excellent inter-rater and intra-rater reliability.
PRODUCTION AND NUTRITIONAL EVALUATION OF FISH OIL AND SOYA OIL EXTRACT
Authors:   Department of Biology, Kogi State College of Education, Ankpa., A. Ibrahim Aminu
Published: June 2021

Studies have shown that fish oil and soybean oil are of excellent public and medical importance to humans. The health benefits of the oils have been widely documented. The purpose of the present study was to manufacture and evaluate the nutritional properties of fish and soybean oil obtained in Nigeria. The oils were extracted from fish and soybean seeds using existing procedures. Thirty liters of the oils were extracted, respectively, and the nutritional contents and other properties were determined. The study provided insight into the nutritional composition of fish oil and soybean oil. The findings and recommendations are discussed.
SCHWANNOME DU NERF MEDIAN ET DU NERF SAPHENE :A PROPOS DE 2 CAS
Authors:   Service de Radiologie, Hopital Arrazi, Centre Hospitalier Universitaire Mohammed VI de Marrakech, Maroc., Mahad Rim , Abidine Lkbir ,   Service de Radiologie, Hopital Arrazi, Centre Hospitalier Universitaire Mohammed VI de Marrakech, Maroc., Boutakioute Badre ,   Service de Radiologie, Hopital Arrazi, Centre Hospitalier Universitaire Mohammed VI de Marrakech, Maroc., Ouali Idrissi Meriem ,   Service de Radiologie, Hopital Arrazi, Centre Hospitalier Universitaire Mohammed VI de Marrakech, Maroc., Cherif Idrissi El Ganouni Najat ,   Service de Radiologie, Hopital Arrazi, Centre Hospitalier Universitaire Mohammed VI de Marrakech, Maroc.
Published: June 2021

Le schwannome est une tumeur nerveuse benigneavec un risque faible de transformation maligne. LIRM permet dorienter le diagnostic et lexamen anatomopathologique confirme le diagnostic. La chirurgie est le traitement ideal par enucleation avec respect de la continuite du nerf.Nous rapportons deux cas dun schwannome benin developpe aux depens du nerfsaphene et du nerf median.
INFARCTUS OSSEUX ASSOCIES A DES OSTEONECROSESEPIPHYSAIRES CHEZ UN SUJET JEUNE DE DECOUVERTE POST TRAUMATIQUE: A PROPOS DUN CAS ET REVUE DE LITTERATURE
Authors:   Service de Radiologie, Hopital Arrazi, CHU Mohammed VI Marrakech, Maroc., Mahad R. , Ahmanna H-C ,   Service de Radiologie, Hopital Arrazi, CHU Mohammed VI Marrakech, Maroc., Boutakioute B. ,   Service de Radiologie, Hopital Arrazi, CHU Mohammed VI Marrakech, Maroc., Ouali Idrissi M. ,   Service de Radiologie, Hopital Arrazi, CHU Mohammed VI Marrakech, Maroc., Cherif Idrissi Elganouni N. ,   Service de Radiologie, Hopital Arrazi, CHU Mohammed VI Marrakech, Maroc.
Published: June 2021

La prevalence de linfarctus osseux est mal definie vue le nombre restreint de cas decrits dans la litterature. Son association avec losteonecroseepiphysaireest frequente. Le diagnostic repose exclusivement sur limagerie, essentiellement la radiographie standard et IRM. Notre travail illustre un cas dinfarctus osseux associe a des osteonecroses epiphysaires chez un sujet jeune de decouverte post traumatique.
UNILATERAL BIJAW PREMOLAR EXTRACTIONS FOR CORRECTION OF CROWDING, BUCCALLY PLACED CANINES AND ASYMMETRIC DENTAL MIDLINE - A CASE REPORT
Authors:   Professor, Dept of Orthodontics and Dentofacial Orthopedics, Sinhgad Dental College and Hospital, VadgaonBk, Pune, Maharashtra, India., Jawale Bhushan , Rodrigues Lishoy ,   PG Student, Dept of Orthodontics and Dentofacial Orthopedics, Sinhgad Dental College and Hospital, VadgaonBk, Pune, Maharashtra, India., Suryavanshi RK ,   Professor and HOD , Dept of Oral and Maxillofacial Surgery, Sinhgad Dental College and Hospital, VadgaonBk, Pune, Maharashtra, India., Gawande Pushkar ,   Reader, Dept of Oral and Maxillofacial Surgery, Sinhgad Dental College and Hospital, VadgaonBk, Pune, Maharashtra, India., Nagarhalli Kiran ,   Private Practice, Bangalore, Karnataka, India., K. Sujala ,   Professor, Dept of Orthodontics and Dentofacial Orthopedics,KLE Dental College and Hospital, Bangalore, Karnataka, India., Patil Neeraj ,   Private Practice, Jalgaon,Maharashtra, India.
Published: June 2021

This case report is of a 22 year old male patient who presented with irregularly placed and crowded teeth in bothmaxillary and mandibular arch on the right side with both upper and lower dental midlines shifted to the patients right. This case was corrected non surgically merely by employing simple mechanics with the help of Fixed Orthodontic Mechanotherapy by extracting a single maxillary and mandibular 1st premolar of right side followed by retraction and closure of spaces with the help of Elastomeric chains. The case ended in a Class I Molar and canine relationship bilaterally. The case report emphasizes on the need for extracting 1st premolars only on 1 side in the upper and lower arch for the purpose of correcting the shifted dental midlines. The extractions also favour correction of crowding and buccally placed upper and lower canines on the right side. Following fixed orthodontic treatment, marked improvement in patients smile was achieved and there was a remarkable increase in the patients confidence and quality of lifeThe profile changes and treatment results were demonstrated with proper case selection and good patient cooperation with Fixed appliance therapy. The patient was extremely satisfied with the results at the end of treatment.