bluuebunny/crossref_metadata_2025 huggingface dataset:
GNSS/AQUA Fusion Study of Atmospheric Response Characteristics and Interaction Mechanisms during the 2022 Tonga Volcanic Eruption
Authors: Ming Lulu , Ke Fuyang , Hu Xiangxiang , Cui Wanganyin , Zhao Pan
Published: October 2023

A large-scale underwater volcanic eruption occurred at the volcano of Hunga Tonga-Hunga Ha’apai (HTHH) on 15 January 2022. At present, there is no consensus on the ionospheric response characteristics and interaction mechanism during volcanic eruptions. Based on the Global Navigation Satellite System (GNSS), AQUA satellite’s Atmospheric Infrared Sounder (AIRS), the experiment studies the response characteristics of the ionosphere and gravity waves during the eruption of the volcano and their interaction mechanisms and the International Real-Time Geomagnetic Observation Network (INTERMAGNET). First, a geomagnetic anomaly was detected before the eruption, which caused variations in the ionospheric VTEC (Vertical Total Electron Content) by about 15 TECU. Based on the IGS (International GNSS Service) observations, the VTEC distribution between 60° north and south latitudes was retrieved. The results show that before and after the eruption of Tonga Volcano, significant ionospheric anomalies were observed to the south, northwest and southwest of the volcano, with a maximum anomaly of 15 TECU. The study indicates that the geomagnetic anomaly disturbance is one of the precursors of volcanic eruption and has a certain degree of impact on the ionosphere. A correlation between geomagnetic anomalies and ionospheric anomalies was found to exist. The vast impact from the volcanic eruption excites gravity waves over the surface, which then propagate longitudinally, further perturbing the ionosphere. It is also detected that the ionospheric anomaly perturbation has a high coincidence effect with the gravity wave anomaly. Therefore, the gravity waves generated by atmospheric variations are used to explain the ionospheric perturbation phenomenon caused by volcanic eruptions.
Inactivation Kinetics of Foodborne Pathogens in Carrot Juice by High-Pressure Processing
Authors: Hwang Chiu-Chu , Lin Chung-Saint , Hsiao Yun-Ting , Huang Ya-Ling , Yen Feng-Lin , Lee Yi-Chen , Tsai Yung-Hsiang
Published: October 2023

In this study, Salmonella Typhimurium, Escherichia coli, and Listeria monocytogenes were separately inoculated in sterilized carrot juice and subjected to various types of high-pressure processing (HPP) at 200–600 MPa for 0.1–15 min to observe the effects of HPP on the inactivation kinetics of foodborne pathogens in carrot juice. The first-order model fits the destruction kinetics of high pressure on foodborne pathogens during the pressure hold period. An increase in pressure from 200 to 600 MPa decreased the decimal reduction time (D values) of S. Typhimurium, E. coli, and L. monocytogenes. Under pressure ≥ 400 MPa, the D values of E. coli were significantly higher than those of S. Typhimurium and L. monocytogenes, indicating that E. coli had greater resistance to high pressures than the others. The Zp values (the pressure range that causes the D values to change by 90%) of E. coli, S. Typhimurium, and L. monocytogenes were 195, 175, and 170 MPa, respectively. These results indicated that L. monocytogenes and E. coli were the most and least sensitive, respectively, to pressure changes. Additionally, the three bacteria were separately inoculated into thermal-sterilized carrot juice and subjected to 200–600 MPa HPP for 3 min. The treated carrot juices were stored at 4 °C for 27 d. Following S. Typhimurium and E. coli inoculation, the bacterial counts of the control and 200 MPa treatments remained the same during the storage duration. However, they decreased for the 300 and 400 MPa treatment groups with increasing storage duration. During the storage period, no bacterial growth was observed in the 500 and 600 MPa treatments. However, the bacterial number for the control and pressure treatment groups increased with prolonged storage duration following inoculation with L. monocytogenes. Therefore, following HPP, residual L. monocytogenes continued growing stably at low temperatures. Overall, HPP could inhibit and delay the growth of S. Typhimurium and E. coli in carrot juice during cold storage, but it was ineffective at inhibiting the growth of L. monocytogenes. There was a risk of foodborne illness despite the low-temperature storage of juice. The innovation of this preliminary study is to find the impact of high pressure on the inactivate kinetics of three food pathogens in carrot juice and its practical application in simulated contaminated juice.
Protein-Targeting Drug Discovery
Authors: Vicidomini Caterina , Roviello Giovanni N.
Published: October 2023

Protein-driven biological processes play a fundamental role in biomedicine because they are related to pathologies of enormous social impact, such as cancer, neuropathies, and viral diseases, including the one at the origin of the recent COVID-19 pandemic [...]
Prolonged Door-to-Balloon Time Leads to Endothelial Glycocalyx Damage and Endothelial Dysfunction in Patients with ST-Elevation Myocardial Infarction
Authors: Vahldieck Carl , Fels Benedikt , Löning Samuel , Nickel Laura , Weil Joachim , Kusche-Vihrog Kristina
Published: October 2023

Damage to the endothelial glycocalyx (eGC) has been reported during acute ischemic events like ST-elevation myocardial infarction (STEMI). In STEMI, a door-to-balloon time (D2B) of <60 min was shown to reduce mortality and nonfatal complications. Here, we hypothesize that eGC condition is associated with D2B duration and endothelial function during STEMI. One hundred and twenty-six individuals were analyzed in this study (STEMI patients vs. age-/sex-matched healthy volunteers). After stimulating endothelial cells with patient/control sera, the eGC’s nanomechanical properties (i.e., height/stiffness) were analyzed using the atomic force microscopy-based nanoindentation technique. eGC components were determined via ELISA, and measurements of nitric oxide levels (NO) were based on chemiluminescence. eGC height/stiffness (both p < 0.001), as well as NO concentration (p < 0.001), were reduced during STEMI. Notably, the D2B had a strong impact on the endothelial condition: a D2B > 60 min led to significantly higher serum concentrations of eGC components (syndecan-1: p < 0.001/heparan sulfate: p < 0.001/hyaluronic acid: p < 0.0001). A D2B > 60 min led to the pronounced loss of eGC height/stiffness (both, p < 0.001) with reduced NO concentrations (p < 0.01), activated the complement system (p < 0.001), and prolonged the hospital stay (p < 0.01). An increased D2B led to severe eGC shedding, with endothelial dysfunction in a temporal context. eGC components and pro-inflammatory mediators correlated with a prolonged D2B, indicating a time-dependent immune reaction during STEMI, with a decreased NO concentration. Thus, D2B is a crucial factor for eGC damage during STEMI. Clinical evaluation of the eGC condition might serve as an important predictor for the endothelial function of STEMI patients in the future.
Investigating Cerebellar Modulation of Premovement Beta-Band Activity during Motor Adaptation
Authors: Kaethler Lynea B. , Brown Katlyn E. , Meehan Sean K. , Staines W. Richard
Published: October 2023

Enhancing cerebellar activity influences motor cortical activity and contributes to motor adaptation, though it is unclear which neurophysiological mechanisms contributing to adaptation are influenced by the cerebellum. Pre-movement beta event-related desynchronization (β-ERD), which reflects a release of inhibitory control in the premotor cortex during movement planning, is one mechanism that may be modulated by the cerebellum through cerebellar-premotor connections. We hypothesized that enhancing cerebellar activity with intermittent theta burst stimulation (iTBS) would improve adaptation rates and increase β-ERD during motor adaptation. Thirty-four participants were randomly assigned to an active (A-iTBS) or sham cerebellar iTBS (S-iTBS) group. Participants performed a visuomotor task, using a joystick to move a cursor to targets, prior to receiving A-iTBS or S-iTBS, following which they completed training with a 45° rotation to the cursor movement. Behavioural adaptation was assessed using the angular error of the cursor path relative to the ideal trajectory. The results showed a greater adaptation rate following A-iTBS and an increase in β-ERD, specific to the high β range (20–30 Hz) during motor planning, compared to S-iTBS, indicative of cerebellar modulation of the motor cortical inhibitory control network. The enhanced release of inhibitory activity persisted throughout training, which suggests that the cerebellar influence over the premotor cortex extends beyond adaptation to other stages of motor learning. The results from this study further understanding of cerebellum-motor connections as they relate to acquiring motor skills and may inform future skill training and rehabilitation protocols.
Quantitative Evaluation of Apparent Diffusion Coefficient Values, ISUP Grades and Prostate-Specific Antigen Density Values of Potentially Malignant PI-RADS Lesions
Authors: Spadarotto Nadine , Sauck Anja , Hainc Nicolin , Keller Isabelle , John Hubert , Hohmann Joachim
Published: October 2023

The aim of this study was to demonstrate the correlation between ADC values and the ADC/PSAD ratio for potentially malignant prostate lesions classified into ISUP grades and to determine threshold values to differentiate benign lesions (noPCa), clinically insignificant (nsPCa) and clinically significant prostate cancer (csPCa). We enrolled a total of 403 patients with 468 prostate lesions, of which 46 patients with 50 lesions were excluded for different reasons. Therefore, 357 patients with a total of 418 prostate lesions remained for the final evaluation. For all lesions, ADC values were measured; they demonstrated a negative correlation with ISUP grades (p < 0.001), with a significant difference between csPCa and a combined group of nsPCa and noPCa (ns-noPCa, p < 0.001). The same was true for the ADC/PSAD ratio, but only the ADC/PSAD ratio proved to be a significant discriminator between nsPCa and noPCa (p = 0.0051). Using the calculated threshold values, up to 31.6% of biopsies could have been avoided. Furthermore, the ADC/PSAD ratio, with the ability to distinguish between nsPCa and noPCa, offers possible active surveillance without prior biopsy.
Immune Checkpoint Pathway Expression in Lymphocyte Subpopulations in Patients with Common Variable Immunodeficiency and Chronic Lymphocytic Leukemia
Authors: Mertowska Paulina , Mertowski Sebastian , Smolak Konrad , Kita Aleksandra , Kita Gabriela , Guz Katarzyna , Pasiarski Marcin , Grywalska Ewelina
Published: October 2023

This study aims to gain a deeper understanding of chronic lymphocytic leukemia (CLL) and common variable immunodeficiency (CVID) by studying immune cells and specific immune checkpoint signaling pathways. The analysis of the percentage of selected immune points and their ligands (PD-1/PD-L1, CTLA-4/CD86, and CD200R/CD200) on peripheral blood lymphocyte subpopulations was performed using flow cytometry, and additional analyses determining the serum concentration of the above-mentioned molecules were performed using enzyme immunoassay tests. The obtained results indicate several significant changes in the percentage of almost all tested molecules on selected subpopulations of T and B lymphocytes in both CVID and CLL patients in relation to healthy volunteers and between the disease subunits themselves. The results obtained were also supported by the analysis of the serum concentration of soluble molecules tested. By uncovering valuable insights, we hope to enhance our comprehension and management of these conditions, considering both immunodeficiencies and hematological malignancies. Understanding the role of these signaling pathways in disease development and progression may lead to the development of modern, personalized diagnostic and therapeutic strategies. Ultimately, this knowledge may enable the monitoring of the immune system in patients with CVID and CLL, paving the way for improved patient care in the future.
Leveraging Attention-Based Convolutional Neural Networks for Meningioma Classification in Computational Histopathology
Authors: Sehring Jannik , Dohmen Hildegard , Selignow Carmen , Schmid Kai , Grau Stefan , Stein Marco , Uhl Eberhard , Mukhopadhyay Anirban , Németh Attila , Amsel Daniel , Acker Till
Published: October 2023

Convolutional neural networks (CNNs) are becoming increasingly valuable tools for advanced computational histopathology, promoting precision medicine through exceptional visual decoding abilities. Meningiomas, the most prevalent primary intracranial tumors, necessitate accurate grading and classification for informed clinical decision-making. Recently, DNA methylation-based molecular classification of meningiomas has proven to be more effective in predicting tumor recurrence than traditional histopathological methods. However, DNA methylation profiling is expensive, labor-intensive, and not widely accessible. Consequently, a digital histology-based prediction of DNA methylation classes would be advantageous, complementing molecular classification. In this study, we developed and rigorously assessed an attention-based multiple-instance deep neural network for predicting meningioma methylation classes using tumor methylome data from 142 (+51) patients and corresponding hematoxylin-eosin-stained histological sections. Pairwise analysis of sample cohorts from three meningioma methylation classes demonstrated high accuracy in two combinations. The performance of our approach was validated using an independent set of 51 meningioma patient samples. Importantly, attention map visualization revealed that the algorithm primarily focuses on tumor regions deemed significant by neuropathologists, offering insights into the decision-making process of the CNN. Our findings highlight the capacity of CNNs to effectively harness phenotypic information from histological sections through computerized images for precision medicine. Notably, this study is the first demonstration of predicting clinically relevant DNA methylome information using computer vision applied to standard histopathology. The introduced AI framework holds great potential in supporting, augmenting, and expediting meningioma classification in the future.
Combined Transarterial Chemoembolization and Radiofrequency Ablation for Hepatocellular Carcinoma Infeasible for Ultrasound-Guided Percutaneous Radiofrequency Ablation: A Comparative Study with General Ultrasound-Guided Radiofrequency Ablation Outcomes
Authors: Cha Dong Ik , Lee Min Woo , Hyun Dongho , Ahn Soo Hyun , Jeong Woo Kyoung , Rhim Hyunchul
Published: October 2023

Objectives: This study aimed to evaluate the therapeutic outcomes of transarterial chemoembolization combined with radiofrequency ablation (TACE + RFA) for hepatocellular carcinomas (HCC) measuring ≤3 cm infeasible for ultrasound (US)-guided percutaneous RFA. Methods: Twenty-four patients who underwent fluoroscopy-guided TACE + RFA for single HCC between January 2012 and December 2016 were screened. To evaluate the TACE + RFA outcomes compared with those of US-guided RFA, 371 patients who underwent US-guided RFA during the same period were screened. We compared local tumor progression (LTP) and intrahepatic distant recurrence (IDR) between the two groups before and after propensity score (PS) matching, and performed univariable and multivariable Cox proportional hazard regression analyses for all patients. Results: PS matching yielded 21 and 42 patients in the TACE + RFA and US-guided RFA groups, respectively. Cumulative LTP rates after PS matching were not significantly different between the two groups at 1 (0.0% vs. 7.4%, p = 0.072), 2 (10.5% vs. 7.4%, p = 0.701), and 5 years (16.9% vs. 10.5%, p = 0.531). IDR rates did not differ significantly between the two groups at 1 (20.6% vs. 10%, p = 0.307), 2 (25.9% vs. 25.9%, p = 0.999), or 5 years (49.9% vs. 53%, p = 0.838). Multivariable analysis showed that treatment type was not a significant factor for LTP or IDR. Conclusion: The outcomes of TACE + RFA for HCC were similar to those of general US-guided RFA. Fluoroscopy-guided TACE + RFA may be an effective treatment when US-guided RFA is not feasible.
No Association of Trichomonas vaginalis Seropositivity with Advanced Prostate Cancer Risk in the Multiethnic Cohort: A Nested Case-Control Study
Authors: Nagata Michelle , Tome Anne , White Kami , Wilkens Lynne R. , Park Song-Yi , Le Marchand Loïc , Haiman Christopher , Hernandez Brenda Y.
Published: October 2023

The potential involvement of a sexually transmitted agent has been suggested to contribute to the high number of prostate cancers in the United States and worldwide. We investigated the relationship of Trichomonas vaginalis seropositivity with prostate cancer risk in a nested case–control study within the Multiethnic Cohort in Hawaii and California using blood samples collected prior to cancer diagnoses. Incident cases of advanced prostate cancer (intermediate- to high-grade based on Gleason score ≥ 7 and/or disease spread outside the prostate) were matched to controls by age, ethnicity, and the date of blood collection. T. vaginalis serostatus was measured using an ELISA detecting IgG antibodies against a recombinant T. vaginalis α-actinin protein. Seropositivity to T. vaginalis was observed in 35 of 470 (7.4%) cases and 26 of 470 (5.5%) controls (unadjusted OR = 1.47, 95% CI 0.82–2.64; adjusted OR = 1.31, 95% CI 0.67–2.53). The association was similarly not significant when cases were confined to extraprostatic tumors having regional or distant spread (n = 121) regardless of grade (unadjusted OR = 1.37, 95% CI 0.63–3.01; adjusted OR = 1.20, 95% CI 0.46–3.11). The association of T. vaginalis with prostate cancer risk did not vary by aspirin use. Our findings do not support a role for T. vaginalis in the etiology of advanced prostate cancer.
PD-L1 and HIF-2α Upregulation in Head and Neck Paragangliomas after Embolization
Authors: Fischer Alessa , Maccio Umberto , Wang Katharina , Friemel Juliane , Broglie Daeppen Martina A. , Vetter Diana , Lehmann Kuno , Reul Astrid , Robledo Mercedes , Hantel Constanze , Bechmann Nicole , Pacak Karel , Zitzmann Kathrin , Auernhammer Christoph J. , Grossman Ashley B. , Beuschlein Felix , Nölting Svenja
Published: October 2023

Hypoxia activates pathways associated with tumor progression, metastatic spread, and alterations in the immune microenvironment leading to an immunosuppressive phenotype. In particular, the upregulation of PD-L1, a target for therapy with checkpoint inhibitors, is well-studied in several tumors. However, the relationship between hypoxia and PD-L1 regulation in pheochromocytomas and paragangliomas (PPGL), and especially in paragangliomas treated with embolization, is still largely unexplored. We investigated the expression of the hypoxia-marker HIF-2α and of PD-L1 in a PPGL-cohort with and without embolization as potential biomarkers that may predict the response to treatment with HIF-2α and checkpoint inhibitors. A total of 29 tumor samples from 25 patients who were operated at a single center were included and analyzed utilizing immunohistochemistry (IHC) for PD-L1 and HIF-2α. Embolization prior to surgery was performed in seven (24%) tumors. PD-L1 expression in tumor cells of head and neck paragangliomas (HNPGLs) receiving prior embolization (median PD-L1 positivity: 15%) was significantly higher as compared to PD-L1 expression in HNPGLs without prior embolization (median PD-L1 positivity: 0%) (p = 0.008). Consistently, significantly more HNPGLs with prior embolization were positive for HIF-2α (median nuclear HIF-2α positivity: 40%) as compared to HNPGLs without prior embolization (median nuclear HIF-2α positivity: 0%) (p = 0.016). Our results support the hypothesis that embolization with subsequent hypoxia leads to the upregulation of both PD-L1 and HIF-2α in HNPGLs, and could thus facilitate targeted treatment with HIF-2α and checkpoint inhibitors in the case of inoperable, locally advanced, or metastatic disease.
Postbiotic Fractions of Probiotics Lactobacillus plantarum 299v and Lactobacillus rhamnosus GG Show Immune-Modulating Effects
Authors: Magryś Agnieszka , Pawlik Mateusz
Published: October 2023

Probiotic bacteria belonging to Lactobacillus spp. are important producers of bioactive molecules, known as postbiotics, that play essential roles in the immunological support of the intestinal mucosa. In this study, the system of co-culture of intestinal epithelial cells with macrophage cells in vitro was used to study the potential effect of postbiotic fractions of L. rhamonosus and L. plantarum on the modulation of the immune response induced by pro-inflammatory stimuli. This study’s results revealed that the presence of probiotic bacterial components on the mucosal surface in the early and late stage of inflammatory conditions is based on cellular interactions that control inflammation and consequent damage to the intestinal epithelium. In our studies, heat killed fractions of probiotic bacteria and their extracted proteins showed a beneficial effect on controlling inflammation, regardless of the strain tested, consequently protecting intestinal barrier damage. In conclusion, the presented results emphasize that the fractions of probiotic bacteria of L. plantarum and L. rhamnosus may play a significant role in the regulation of LPS-mediated cytotoxic activity in intestinal epithelial cells. The fractions of probiotic strains of L. rhamnosus and L. plantarum showed the potential to suppress inflammation, effectively activating the anti-inflammatory cytokine IL-10 and modulating the IL-18-related response.
Identification of Small Molecules for Prevention of Lens Epithelium-Derived Cataract Using Zebrafish
Authors: Taler Kineret , Zatari Nour , Lone Mohammad Iqbal , Rotem-Bamberger Shahar , Inbal Adi
Published: October 2023

Cataract is the leading cause of blindness worldwide. It can be treated by surgery, whereby the damaged crystalline lens is replaced by a synthetic lens. Although cataract surgery is highly effective, a relatively common complication named posterior capsular opacification (PCO) leads to secondary loss of vision. PCO is caused by abnormal proliferation and migration of residual lens epithelial cells (LECs) that were not removed during the surgery, which results in interruption to the passage of light. Despite technical improvements to the surgery, this complication has not been eradicated. Efforts are being made to identify drugs that can be applied post-surgery, to inhibit PCO development. Towards the goal of identifying such drugs, we used zebrafish embryos homozygous for a mutation in plod3 that develop a lens phenotype with characteristics of PCO. Using both biased and unbiased approaches, we identified small molecules that can block the lens phenotype of the mutants. Our findings confirm the relevance of zebrafish plod3 mutants’ lens phenotype as a model for lens epithelium-derived cataract and add to our understanding of the molecular mechanisms that contribute to the development of this pathology. This understanding should help in the development of strategies for PCO prevention.
Unveiling the Magnetic and Structural Properties of (X2YZ; X = Co and Ni, Y = Fe and Mn, and Z = Si) Full-Heusler Alloy Microwires with Fixed Geometrical Parameters
Authors: Salaheldeen Mohamed , Zhukova Valentina , Ipatov Mihail , Zhukov Arcady
Published: October 2023

We studied Ni2FeSi-, Co2FeSi-, and Co2MnSi-based full-Heusler alloy glass-coated microwires with the same geometric parameters, i.e., fixed nucleus and total diameters, prepared using the Taylor–Ulitovsky method. The fabrication of X2YZ (X = Co and Ni, Y = Fe and Mn, and Z = Si)-based glass-coated microwires with fixed geometric parameters is quite challenging due to the different sample preparation conditions. The XRD analysis showed a nanocrystalline microstructure for all the samples. The space groups Fm3¯m (FCC) and Im3¯m (BCC) with disordered B2 and A2 types are observed for Ni2FeSi and Co2FeSi, respectively. Meanwhile, a well-defined, ordered L21 type was observed for Co2MnSi GCMWs. The change in the positions of Ni, Co and Mn, Fe in X2YSi resulted in a variation in the lattice cell parameters and average grain size of the sample. The room-temperature magnetic behavior showed a dramatic change depending on the chemical composition, where Ni2FeSi MWs showed the highest coercivity (Hc) compared to Co2FeSi and Co2MnSi MWs. The Hc value of Ni2FeSi MWs was 16 times higher than that of Co2MnSi MWs and 3 times higher than that of Co2FeSi MWs. Meanwhile, the highest reduced remanence was reported for Co2FeSi MWs (Mr = 0.92), being about 0.82 and 0.22 for Ni2FeSi and Co2MnSi MWs, respectively. From the analysis of the temperature dependence of the magnetic properties (Hc and Mr) of X2YZ MWs, we deduced that the Hc showed a stable tendency for Co2MnSi and Co2FeSi MWs. Meanwhile, two flipped points were observed for Ni2FeSi MWs, where the behavior of Hc changed with temperature. For Mr, a monotonic increase on decreasing the temperature was observed for Co2FeSi and Ni2FeSi MWs, and it remained roughly stable for Co2MnSi MWs. The thermomagnetic curves at low magnetic field showed irreversible magnetic behavior for Co2MnSi and Co2FeSi MWs and regular ferromagnetic behavior for Ni2FeSi MWs. The current result illustrates the ability to tailor the structure and magnetic behavior of X2YZ MWs at fixed geometric parameters. Additionally, a different behavior was revealed in X2YZ MWs depending on the degree of ordering and element distribution. The tunability of the magnetic properties of X2YZ MWs makes them suitable for sensing applications.
Terrestrial Alien Flora of the Iberian Alboran Coast: Assessment, Attributes, and Future Implications
Authors: Goncalves Estefany , Casimiro-Soriguer Solanas Federico , García-Caballero Javier , Hidalgo-Triana Noelia
Published: October 2023

Although Mediterranean coastal regions in southern Spain have high floristic diversity and numerous Habitats of Community Interest (HCIs) identified by the European Union Directive Council, they are also vulnerable to invasive plants. In our study, we aimed to create a checklist of terrestrial alien taxa in the Iberian area of the Alboran coast, assess each species’ current invasion, analyse the influence of environmental attributes on invasion, estimate the richness of alien species per HCI group, and evaluate each species’ potential invasiveness based on its reproductive and dispersal attributes. The checklist that we developed includes 123 alien taxa, most belonging to the Asteraceae, Asparagaceae, and Poaceae families. Notably, 20% of the species are super invaders that occupy more than 20% of HCIs. We also identified Aloe vera, Cylindropuntia spp., Agave salmiana, Opuntia spp., and Paspalum spp. as incipient invaders with the potential for future expansion. Although most alien flora in the HCIs are not regulated by Spanish legislation (RDL 630/2013), monitoring and eradication plans are crucial. Advocating the cessation of using those plants in gardens and reducing anthropogenic pressure are also essential, as human activities worsen invasion dynamics and facilitate the introduction and establishment of invasive species.
A Holistic Model for Disciplinary Professional Development—Overcoming the Disciplinary Barriers to Implementing ICT in Teaching
Authors: Amir Alisa
Published: October 2023

What helps teachers overcome technological barriers to Information and Communications Technology (ICT) implementation in their subject domains? Can a disciplinary professional development model help reduce these disciplinary barriers? To answer these questions, this mixed-methods case study examines the change in digital ICT implementation and its barriers among secondary school first language teachers after the utilization of a holistic model for disciplinary professional development (language, science, etc.). Ninety-two first language teachers participated in a professional development program that included a unique instructor profile, theoretical and practical training, technical support, and ongoing individual and school-wide didactic and pedagogical support. The teachers’ experiences and changes in their personal general experience during their professional development were then assessed via interviews and open-ended questionnaires. The findings indicate that the unique professional development model largely removed the teachers’ disciplinary barriers. Specifically, during their professional development, the teachers changed their perceptions of the purposes of ICT in first language teaching in general and teaching writing in particular, indicating that they realized that ICT promotes their discipline and is not merely a tool for lesson diversification or intrigue. Furthermore, they recognized that ICT is not an option but an integral part of teaching in the 21st century.
An Integrated Scheme for Forecasting and Controlling Ramps in Offshore Wind Farms Considering Wind Power Uncertainties during Extreme Storms
Authors: Jia Yongyong , Ren Bixing , Li Qiang , Wang Chenggen , Wang Dajiang , Zou Xiaoming
Published: October 2023

Global warming-induced extreme tropical storms disrupt the operation of offshore wind farms, causing wind power ramp events and threatening the safety of the interconnected onshore grid. In order to attenuate the impact of these ramps, this paper proposes an integrated strategy for forecasting and controlling ramps in offshore wind farms. First, the characteristics of wind power ramps during tropical storms are studied, and a general ramp control framework is established. Second, a wind power ramp prediction scheme is designed based on a minimal gated memory network (MGMN). Third, by taking into account the wind power ramp prediction results and wind power uncertainties, a chance-constraint programming-based optimal ramp control scheme is developed to simultaneously maximize wind power absorption and minimize ramp control costs. Finally, we use real-world offshore wind farm data to validate the effectiveness of the proposed strategy.
Saliency Ratio-Based Torque Enhancement of Switched Reluctance Motors for Electric Bikes
Authors: Ghani Abdul , Khalid Hassan Abdullah , Rehman Habibur
Published: October 2023

Switched reluctance motors (SRMs) face challenges in achieving high performances in terms of the power factor, torque per ampere, and torque ripples. Although several parameters impact their performance, magnetic saliency has a significant impact. This paper presents a study on the influence of the saliency ratio on the performance of switched reluctance motors. A detailed design procedure for a mid-drive electric motor for a high-performance electric bike is presented. A systematic methodology is adopted to estimate the power rating for desired vehicle performance while considering the vehicle’s mechanical and aerodynamic parameters. Additionally, the paper discusses and analyzes the design of two SRM motor configurations with different rotor poles (6/4 and 6/10) while performing magnetostatic analysis for generated torque validation. A parametric study is performed on the 6/10 SRM design for further improvement in the torque profile while keeping the same fill factor and electrical loading. Furthermore, the transient analysis in Ansys Maxwell 2D for both SRMs confirms the designed performance. The results shows that the SRM with higher rotor poles (6/10) is a better choice.
Research on Heat Generation Law and Cooling System Performance of Hydraulic System of Combined Machine Tool
Authors: Zhang Qinguo , Liu Xiaojian , Tong Zheming , Cheng Zhewu
Published: October 2023

After the machine tool works continuously, the temperature of the hydraulic system continues to rise, which affects the work efficiency of the machine tool. Therefore, it is very important to control the temperature within a reasonable range. This paper proposes an improved scheme to replace a single fan with dual fans to improve the heat dissipation capacity of the radiator. Starting from the principle of heat exchange between oil and air, the relationship between the oil temperature and the wind speed on the face of the heat exchanger is derived, and the theoretical basis of the cooling system is given. Combined with logic control, the fan has the advantages of fast action, high efficiency and low energy consumption, which ensures the efficient and reliable operation of the machine tool. A one-dimensional simulation model of the thermal hydraulic system is established, and the heat generation and heat dissipation power of each element are calculated. Among them, the heat dissipation of the radiator is the largest, accounting for about 55% of the total heat dissipation. The experimental results show that the optimal fan speed is 3200 r/min and the flow rate is 0.2 m3/s at 26 °C. The thermal balance temperature of the hydraulic system is reduced from the original 65 °C to 58 °C, and its cooling capacity meets the requirements of a high-altitude and high-temperature environment.
Vertical Relationships with Hidden Interactions
Authors: Kim Jaesoo , Shin Dongsoo
Published: October 2023

In an agency model with adverse selection, we study how hidden interactions between agents affect the optimal contract. The principal employs two agents who learn their task environments through their involvement. The principal cannot observe the task environments. It is important to note that hidden interactions, such as acts of sabotage or help between the agents, have the potential to alter each other’s task environments. Our analysis encompasses two distinct organizational structures: competition and cooperation. Without hidden interactions, the competitive structure is optimal because the cooperative structure only provides the agents with more flexibility to collusively misrepresent their task environments. With hidden interactions, however, the cooperative structure induces the agents to help each other to improve the task environments while removing sabotaging incentives at no cost once collusion is deterred. As a result, the cooperative structure can be optimal in such a case. We discuss the link between production technology and organizational structure, finding that complementarity in production favors cooperative structures.
Biblical Genealogy and Nationalism
Authors: Aberbach David
Published: October 2023

The chronological/genealogical narrative structure of the Hebrew Bible points to an editorial aim: to give a history of Israel as a nation from Creation to the 6th century BCE Babylonian exile and the return to the land of Israel, and in so doing to bring to life and unite two dead Near Eastern kingdoms. This article considers the scribes and editors who created the structure of the Hebrew Bible as forerunners of modern cultural nationalists, especially of defeated or endangered peoples, who sought the survival and growth of the nation in literature. However, the monotheisms that derived from Judaism, and adopted Hebrew scripture as sacred, rarely accepted the Bible as the translation or adaptation of a Jewish work in the Jewish national language mostly on Jewish soil and under Jewish government in the 1st millennium BCE. Rather, anti-Semites taught a genealogy of Jewish guilt to the world, with extra charges based on supersessionist theology and anti-Jewish fantasies.
Survey on the Mental Health of Dispensing Pharmacists in the Auvergne-Rhône-Alpes Region (France)
Authors: Massoubre Bernard , Gabriel-Segard Tristan , Durupt Florence , Malachane Anne-Sophie , Anglard Noémie , Tiffet Théophile , Massoubre Catherine
Published: October 2023

Background: The COVID-19 pandemic intensely involved pharmacists in France, with new responsibilities on a large scale, introducing to dispensary practice the performance of vaccination and nasopharyngeal swabs. This study aimed to assess the prevalence of burnout, anxiety, and depression in pharmacists after the COVID-19 health crisis and to identify factors associated with psychological distress. Methods: A cross-sectional observational study involved 1700 pharmacies in an entire French region. Sociodemographic, geographical, and medical information (burnout tested with the MBI and anxiety/depression measured on the HAD scale) were collected via an online anonymous self-administered questionnaire. The characteristics of the pharmacy and the practice of antigen testing and vaccination were requested. Quantitative and qualitative variables associated with psychological distress were investigated with a factor analysis. Results: In total, 360 responses were collected (20.5%). Of the responses, 41.9% showed definite anxiety symptoms and 18.3% showed proven depressive symptoms. Three clusters were described according to the intensity of burnout experience, depersonalization, and loss of personal accomplishment. The analysis identified that one cluster was at high risk of burnout (high burnout and depersonalization scores). Of these stressed, exhausted pharmacists, 69.3% showed definite anxiety, 37.9% showed proven depression, and in smaller pharmacies. The carrying out of antigenic testing and anti-COVID vaccination, as well as the geographical location of the pharmacy, were not discriminating factors in these three groups. Conclusion: Mental health care and suicide prevention should be provided to at-risk pharmacists. It seems essential to publicize the range of resources available to support pharmacists.
Levels of Total Mercury and Health Risk Assessment of Consuming Freshwater Stingrays (Chondrichthyes: Potamotrygoninae) of the Brazilian Amazon
Authors: Oliveira Adriano Teixeira de , Rodrigues Paloma de Almeida , Ramos Filho Alexandre Mendes , Gomes Maria Fernanda da Silva , Liebl Ariany Rabello da Silva , de Pinho Júlia Vianna , Aride Paulo Henrique Rocha , Conte-Junior Carlos Adam
Published: October 2023

Mercury is an element with potential risk to fish and those who consume it. Thus, this study aimed to determine the levels of total mercury (THg), carry out a health risk assessment related to the consumption of the freshwater stingrays Potamotrygon motoro, and determine the physical and chemical properties of the water where stingrays occur. Stingrays of the species P. motoro were obtained from the Amazon River, and samples of the animals’ musculature were collected to determine THg levels. Risk assessment was conducted using pre-established formulas of estimated monthly intake (EMI), maximum monthly intake rate (IRmm), and hazard quotient (HQ). Three population scenarios were evaluated, considering both sexes and differences between rural and urban areas. There was no relationship between weight and THg concentration nor between total length and THg concentration. Higher EMI values were observed in rural children; for the IRmm, male children had the lowest consumption levels. For the hazard quotient, there was a similarity between the three age groups when comparing the male and female sexes. In addition, the representatives of the rural area always had lower values than the urban area. Freshwater stingrays, like other elasmobranchs, can be crucial animal species because they act as sentinels in studies that assess harmful chemicals like mercury.
Promoting Women’s Well-Being: A Systematic Review of Protective Factors for Work–Family Conflict
Authors: Cavagnis Lucrezia , Russo Claudia , Danioni Francesca , Barni Daniela
Published: October 2023

Work–family conflict is a prominent issue, especially in our society, where people are expected to fulfil many roles simultaneously. Work and family life demands significantly impact an individual’s overall well-being, especially for women, since they typically balance caregiving for children and elderly relatives with careers. Therefore, highlighting which factors might protect women from experiencing work–family conflict is essential to enhance women’s and their family’s well-being. Thus, the main aim of the present study was to systematically review previous research on women’s coping strategies and protective factors which can reduce the negative effects of work–family conflict. Following the PRISMA guidelines, we conducted a literature search of three databases (PubMed, PsycINFO, and Scopus). After the screening and the eligibility phases, we included a final set of 13 studies. Most of these studies adopted a cross-sectional design (N = 10), and a few adopted a longitudinal one (N = 3). Results highlighted the role of different personal (e.g., hardiness, self-esteem, locus of control) and relational factors (e.g., family and work support) that significantly reduce the negative effects of work–family conflict in women’s lives. Findings, practical implications, and future research directions are discussed.
Fluoroquinolone-Based Organic Salts (GUMBOS) with Antibacterial Potential
Authors: Costa Fábio M. S. , Granja Andreia , Pérez Rocío L. , Warner Isiah M. , Reis Salette , Passos Marieta L. C. , Saraiva M. Lúcia M. F. S.
Published: October 2023

Antimicrobial resistance is a silent pandemic considered a public health concern worldwide. Strategic therapies are needed to replace antibacterials that are now ineffective. One approach entails the use of well-known antibacterials along with adjuvants that possess non-antibiotic properties but can extend the lifespan and enhance the effectiveness of the treatment, while also improving the suppression of resistance. In this regard, a group of uniform materials based on organic salts (GUMBOS) presents an alternative to this problem allowing the combination of antibacterials with adjuvants. Fluoroquinolones are a family of antibacterials used to treat respiratory and urinary tract infections with broad-spectrum activity. Ciprofloxacin and moxifloxacin-based GUMBOS were synthesized via anion exchange reactions with lithium and sodium salts. Structural characterization, thermal stability and octanol/water partition ratios were evaluated. The antibacterial profiles of most GUMBOS were comparable to their cationic counterparts when tested against Gram-positive S. aureus and Gram-negative E. coli, except for deoxycholate anion, which demonstrated the least effective antibacterial activity. Additionally, some GUMBOS were less cytotoxic to L929 fibroblast cells and non-hemolytic to red blood cells. Therefore, these agents exhibit promise as an alternative approach to combining drugs for treating infections caused by resistant bacteria.
Top–Down Proteomics of Human Saliva, Analyzed with Logistic Regression and Machine Learning Methods, Reveal Molecular Signatures of Ovarian Cancer
Authors: Scebba Francesca , Salvadori Stefano , Cateni Silvia , Mantellini Paola , Carozzi Francesca , Bisanzi Simonetta , Sani Cristina , Robotti Marzia , Barravecchia Ivana , Martella Francesca , Colla Valentina , Angeloni Debora
Published: October 2023

Ovarian cancer (OC) is the most lethal of all gynecological cancers. Due to vague symptoms, OC is mostly detected at advanced stages, with a 5-year survival rate (SR) of only 30%; diagnosis at stage I increases the 5-year SR to 90%, suggesting that early diagnosis is essential to cure OC. Currently, the clinical need for an early, reliable diagnostic test for OC screening remains unmet; indeed, screening is not even recommended for healthy women with no familial history of OC for fear of post-screening adverse events. Salivary diagnostics is considered a major resource for diagnostics of the future. In this work, we searched for OC biomarkers (BMs) by comparing saliva samples of patients with various stages of OC, breast cancer (BC) patients, and healthy subjects using an unbiased, high-throughput proteomics approach. We analyzed the results using both logistic regression (LR) and machine learning (ML) for pattern analysis and variable selection to highlight molecular signatures for OC and BC diagnosis and possibly re-classification. Here, we show that saliva is an informative test fluid for an unbiased proteomic search of candidate BMs for identifying OC patients. Although we were not able to fully exploit the potential of ML methods due to the small sample size of our study, LR and ML provided patterns of candidate BMs that are now available for further validation analysis in the relevant population and for biochemical identification.
Splanchnic Vein Thrombosis in Myelofibrosis—An Underappreciated Hallmark of Disease Phenotype
Authors: Beleva Elina A.
Published: October 2023

Splanchnic vein thrombosis (SVT) encompasses thrombosis in the vessels of the splanchnic basin and has a relatively rare occurrence with a reported frequency in the general population of 1–2%. An episode of seemingly unprovoked SVT almost always triggers a diagnostic work-up for a Philadelphia chromosome-negative myeloproliferative neoplasm (MPN), since atypical site thrombosis is a hallmark of MPN-associated thrombophilia. Primary myelofibrosis (PMF) is a rare MPN with an estimated incidence between 0.1 and 1/100,000 per year. Although prothrombotic tendency in PMF is not envisioned as a subject of specific therapeutic management, unlike other MPNs, such as polycythemia vera (PV) and essential thrombocythemia (ET), thrombotic risk and SVT prevalence in PMF may be comparably high. Additionally, unlike PV and ET, SVT development in PMF may depend more on procoagulant mechanisms involving endothelium than on blood cell activation. Emerging results from registry data also suggest that PMF patients with SVT may exhibit lower risk and better prognosis, thus highlighting the need for better thrombotic risk stratification and identifying a subset of patients with potential benefit from antithrombotic prophylaxis. This review highlights specific epidemiological, pathogenetic, and clinical features pertinent to SVT in myelofibrosis.
Silver, Its Salts and Application in Medicine and Pharmacy
Authors: Żyro Dominik , Sikora Joanna , Szynkowska-Jóźwik Małgorzata Iwona , Ochocki Justyn
Published: October 2023

The healing properties of silver have been used since ancient times. The main aim of the study was to collect and review the literature on the clinical potential of silver, its salts and complex compounds. The second goal was to present an outline of the historical use of silver in medicine and pharmacy, taking into account the possibility of producing pharmaceutical drug forms on the premises of pharmacies. In the context of the growing resistance of microorganisms to available, widely used antibiotics, silver plays a key role. There is only one known case of bacterial resistance to silver—the Pseudomonas stutzeri strain, which naturally occurs in silver mines. The development of research in the field of coordination chemistry offers great opportunities in the design of new substances in which silver ions can be incorporated. These substances exhibit increased potency and often an extended antimicrobial spectrum. Silver-based compounds are, however, only limited to external applications, as opposed to their historic oral administration. Advanced studies of their physicochemical, microbiological, cytotoxic and genotoxic properties are ongoing and full of challenges. The improvement of the methods of synthesis gives the possibility of applying the newly synthesized compounds ex tempore, as was the case with the complex of metronidazole with silver (I) nitrate. Some of these experimental efforts performed in vitro are followed with clinical trials. The third and final goal of this study was to present the possibility of obtaining an ointment under the conditions of an actual pharmacy using silver (I) salts and a ligand, both of which are active substances with antimicrobial properties.