bluuebunny/crossref_metadata_2025 huggingface dataset:
La ragazza del secolo scorso
Authors: Toro Hernán
Published: November 2022

A partir del título del libro de la revolucionaria italiana Rossana Rossanda, La ragazza del secolo scorso, el autor del presente libro nos propone un cuento homónimo, que a su turno se lo da al libro, en el que se narra la variabilísima condición humana a través de dos personajes que, reencontrados por azar en las gélidas salas de una clínica varias décadas después de sus avatares políticos conjuntos, los enfrenta a las contradicciones emanadas imperceptiblemente de la vida misma. Los otros cuentos de esta colección dejan entrever igualmente hasta qué punto la vida degrada o exalta las existencias y las conduce por vías imprevisibles, como si los seres humanos fueran incapaces de gobernar su propio destino.
Assessment of Cortical Auditory Function Using Electrophysiological and Neuropsychological Measurements in Children with Bone-Anchored Hearing Aids
Authors: Pantelemon Cristina ,   Department of Neurosciences, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania,   “RoNeuro” Institute for Neurological Research and Diagnostic, Cluj-Napoca, Romania, Necula Violeta ,   Department of ENT, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania, Livint Popa Livia ,   Department of Neurosciences, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania,   “RoNeuro” Institute for Neurological Research and Diagnostic, Cluj-Napoca, Romania, Palade Steluta ,   Department of Pediatric Neurology, Children's Emergency Hospital Cluj-Napoca, Cluj-Napoca, Romania, Strilciuc Stefan ,   Department of Neurosciences, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania,   Department of Public Health, Babes-Bolyai University, Cluj-Napoca, Romania,   Stefan Strilciuc, MPH No. 37 Mircea Eliade Street, Cluj-Napoca, Romania, 400354 E-mail: stefan.strilciuc@ssnn.ro, Muresanu Dafin Fior ,   Department of Neurosciences, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania,   “RoNeuro” Institute for Neurological Research and Diagnostic, Cluj-Napoca, Romania
Published: November 2022

Children suffering from conductive or mixed hearing loss may benefit from a bone-anchored hearing aid system (BAHA Attract implantable prosthesis). After audiological rehabilitation, different aspects of development are improving. The objective of this case report is to propose a comprehensive framework for monitoring cortical auditory function after implantation of a bone-anchored hearing aid system by using electrophysiological and neuropsychological measurements.

We present the case of a seven-year-old boy with a congenital hearing loss due to a plurimalformative syndrome, including outer and middle ear malformation. After the diagnosis of hearing loss and the audiological rehabilitation with a BAHA Attract implantable prosthesis, the cortical auditory evoked potentials were recorded. We performed a neuropsychological evaluation using the Wechsler Intelligence Scale for Children – Fourth Edition, which was applied according to a standard procedure.

The P1 latency was delayed according to the age (an objective biomarker for quantifying cortical auditory function). The neuropsychological evaluation revealed that the child’s working memory and verbal reasoning abilities were in the borderline range comparing with his nonverbal reasoning abilities and processing abilities, which were in the average and below-average range, respectively.

Cortical auditory evoked potentials, along with neuropsychological evaluation, could be an essential tool for monitoring cortical auditory function in children with hearing loss after a bone-anchored hearing aid implantation.
Loss of Time in the Treatment Adherence Process: A Qualitative Study in a Sample of Iranian People with Diabetes
Authors: Mousavizadeh Seyedeh Narjes ,   Department of Psychiatric Nursing, Nursing and Midwifery School, Shahid Beheshti University of Medical Sciences, Tehran, Iran,   Seyedeh Narjes Mousavizadeh Shahid Beheshti University of Medical Sciences, Tehran, Iran E-mail: n.mousavi@sbmu.ac.ir Fax: 02188202521, Banazadeh Zahra ,   Iran University of Medical Sciences, Tehran, Iran
Published: November 2022

Diabetes is a significant public health problem and one of the causes of death and disability globally. One of the main problems with diabetes control is the lack of adherence to therapeutic regimens in people with diabetes. This study investigates the experiences and views of the Iranian people with diabetes to identify the challenges of the process of adherence to treatment.

A grounded theory research design was used, incorporating in-depth interviews to collect the data. Using purposeful sampling, 28 people with type 2 diabetes (9 men, 19 women) from different places were included in the study. Constant comparative analysis was undertaken to identify key categories.

The main challenge in this process is losing the golden time of preventing the complications of the disease that occurs for the following reasons: cultural habits and values, religious beliefs (believing diabetes was God’s will), resistance to change due to age, job conditions, lack of harmony in the family, and non-shared decision-making in the health system.

People with diabetes go through trial and error in order to achieve awareness and insight, and consequently, adherence to treatment. Therefore, they need help and support to achieve insight and adherence to treatment faster and without complications. In fact, if the care plan is designed to encourage active patient participation by the treatment team in the shortest possible time, the time to achieve compliance will be shorter and will have the least side effects for these people.
Proposing a Model for the National Hemovigilance Information System in Iran
Authors: Asadi Farkhondeh ,   Department of Health Information Technology and Management, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran,   Farkhondeh Asadi, Department of Health Information Technology and Management, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Phone: +98 21 22747373. E-mail: asadifar@sbmu.ac.ir, Ramezanghorbani Nahid ,   Department of Development & Coordination Scientific Information and Publications, Deputy of Research & Technology, Ministry of Health & Medical Education, Tehran, Iran
Published: November 2022

The present study aimed to propose a model for the national hemovigilance information system with a database approach, considering the importance and necessity of developing an information system for such a network.

This is an applied, descriptive, and cross-sectional study, which was conducted in 2018. The research population comprised hemovigilance information systems in advanced countries, including the USA, UK, Australia, and France. Data were collected from library sources and the Internet from 2000 to 2018. The proposed model for the national hemovigilance information system was introduced using comparative tables and based on the similarities and differences of systems in the studied countries. The proposed model was then validated using the two-step Delphi technique through a researcher-made questionnaire whose validity was confirmed, and reliability was approved by a Cronbach’s alpha of 94%.

The final model of the national hemovigilance information system comprised five main components: goals, organizations involved in the blood transfusion process, databases of blood transfusion organizations, data transfer flow between the databases of blood transfusion organizations, and transferable datasets, and hemovigilance-related committees. This model was approved by experts with an >85% agreement coefficient.

The national hemovigilance information system with a database approach can improve blood transfusion health by providing access to reliable sources on blood transfusion complications to everyone, especially the medical community. Thus, it is essential to implement this standard accurately and precisely control the practical methods of this process based on international guidelines.
Elderly Patients’ Perception of Previewing the Prosthetic Treatment Outcome
Authors: Pantea Mihaela ,   Department of Fixed Prosthodontics and Occlusology, Faculty of Dental Medicine, ”Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Tancu Ana Maria Cristina ,   Department of Complete Denture, Faculty of Dental Medicine, ”Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   Ana Maria Cristina Tancu, Lecturer, Department of Complete Denture, Faculty of Dental Medicine, ”Carol Davila” University of Medicine and Pharmacy, 17-23 Plevnei Str., 010221, Bucharest, Romania E-mail: amctancu@yahoo.com, Phone: +40722664355, Petre Alexandru ,   Department of Fixed Prosthodontics and Occlusology, Faculty of Dental Medicine, ”Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Imre Marina ,   Department of Complete Denture, Faculty of Dental Medicine, ”Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Ionescu Ecaterina ,   Department of Orthodontics and Dento-Facial Orthopedics, Faculty of Dental Medicine, ”Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
Published: November 2022

The demographic statistics indicate that, with the industrial development and the advances in the medical field, the average life of the population has started to increase significantly; consequently, the needs of treatments in geriatric dentistry are becoming more and more significant. The purpose of this study was to evaluate patients� perception of diverse techniques used to obtain previews for final fixed prosthetic restorations: digital smile design (DSD), wax-up, indirect mock-up, temporary restorations, Computer-Aided Design (CAD). A focus group that included 11 participants, all of them geriatric patients, was formed; patients were invited to respond to a set of seven questions before and after various previsualization methods were applied. The focus-group report indicated that the indirect mock-up and the temporary restorations were considered by the geriatric patients as the best methods for obtaining good prosthetic previews. Comparing to the other tested methods, the use of indirect mock-up increased the acceptance of the prosthetic treatment plan and offered the most influential visual impact for 72.7% of participants. In addition, all tested previews allowed excellent communication with patients, the best results being obtained with the temporary prosthetic restorations (for 54.5% of participants). This approach represented a tool for better decisions regarding final dental restoration and has had a positive influence on patients� acceptance of the treatment plan as well, making the final restoration more predictable.
The Effect of Cognitive-Behavioral Counseling on Lifestyle in Pregnant Women: A Randomized Controlled Clinical Trial
Authors: Farhodimoghadam Mahnaz ,   Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran, Heydarpour Sousan ,   Department of Midwifery, Faculty of Nursing and Midwifery, Kermanshah University of Medical Sciences, Kermanshah, Iran.,   Sousan Heydarpour, Department of Midwifery, Faculty of Nursing and Midwifery, Kermanshah University of Medical Sciences, Kermanshah, Iran. E-mail: s.heydarpour1394@yahoo.com, Salari Nader ,   Department of Biostatistics, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran, Jaberghaderi Nasrin ,   Department of Psychiatry, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
Published: November 2022

The lifestyle of pregnant women has a close relationship with maternal and fetal health. In pregnant women, health-promoting behaviors lead to the promotion of quality of life and improvement of pregnancy outcomes. Therefore, the present study aimed to determine the effect of cognitive-behavioral counseling on pregnant women’s lifestyle.

This randomized controlled clinical trial study was performed in the health centers of Sanandaj, Iran. Seventy pregnant women were randomly assigned to intervention (n = 35) and control (n = 35) groups. The study was completed with 33 pregnant women in each group. In addition to routine pregnancy care, the control group received, the intervention group received 8 consecutive 60-90-minute counseling sessions with a cognitive-behavioral approach weekly. The Walker Health Promotion Lifestyle Questionnaire was completed before, immediately, and one month after the intervention by the participants of control and intervention groups. Data were collected from February until June 2017. Data were analyzed using SPSS version 16.

The mean score of lifestyle in the intervention and control group was 139.78 ± 21.71 and 142.63 ± 19.12 before the intervention, which reached 151 ± 17.72 and 159.14 ± 14.77, respectively, after the intervention. The difference was significant in the intervention group (P = 0.001) but not in the control group (P = 0.619). Also, the mean scores of the two groups were not significantly different before intervention (P = 0.574), but this difference was statistically significant after the intervention (P = 0.029) and one month after the intervention (P = 0.001).

Based on the results of this study, cognitive-behavioral counseling improves the lifestyle of pregnant women. Therefore, it is suggested that this type of counseling be used along with other services to improve the lifestyle of pregnant women in health care centers.
A Case Report of a Massive Epignathus
Authors: Naleini Farhad ,   Department of Radiology, Clinical Research Development Center, Kermanshah University of Medical Sciences, Kermanshah, Iran,   Farhad Naleini, Associate Professor Department of Radiology Kermanshah University of Medical Sciences,Kermanshah, Iran E-mail: dr.farhadnaleini@gmail.com, Farshchian Nazanin ,   Department of Radiology, Clinical Research Development Center, Kermanshah University of Medical Sciences, Kermanshah, Iran, Mehrbakhsh Mahmood ,   Department of Radiology, Clinical Research Development Center, Kermanshah University of Medical Sciences, Kermanshah, Iran, Kamangar Parisa Bahrami ,   Kermanshah University of Medical Sciences, Kermanshah, Iran
Published: November 2022

Epignathus is a rare congenital orofacial teratoma. Teratomas are tumors that originate from all three germs cell layers. Tumor size is an important prognostic factor, and we describe the case of massive epignathus identified by sonography at 25 weeks. Our case was a 35-year-old pregnant woman that was subjected to a routine ultrasound at 25 weeks of gestation, and epignathus was diagnosed. Labor pain started in the 28th week of the pregnancy, so the dead fetus was aborted, and curettage was conducted. A pathologic sample was sent to the laboratory, and benign teratoma was diagnosed. Because fetal epignathus has a wide range of outcomes, early prenatal diagnosis is essential for optimal management.
Vitamin D and Immunoglobulin E Status in Allergic Rhinitis Patients Compared to Healthy People
Authors: Alnori Haitham ,   Department of Surgery, College of Medicine, University of Mosul, Mosul, Iraq,   Haitham Alnori,Department of Surgery, College of Medicine,University of Mosul,Mosul Ninavah 00964 Iraq.Phone: 009647701637724 E-mail: haithamabdnori@uomosul.edu.iq, Abdulghani Alassaf Fawaz ,   Department of Pharmacology, College of Pharmacy, University of Mosul, Mosul, Iraq, Alfahad Mohanad ,   Department of Pharmaceutics, College of Pharmacy, University of Mosul, Mosul, Iraq, Emad Qazzaz Mohannad ,   Department of Pharmacognosy and Medicinal Plants, College of Pharmacy, University of Mosul, Mosul, Iraq, Jasim Mahmood ,   Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, Iraq, Najim Abed Mohammed ,   Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, Iraq
Published: November 2022

Allergic rhinitis (AR) is a type of inflammatory condition that includes a group of symptoms, mainly affecting the nasal mucosa. Nasal obstruction, sneezing, stuffy or runny nose, in addition to swollen, itchy, red and watery eyes are the most common symptoms of the disease. These symptoms are triggered as a result of increased inflammatory mediators such as histamine and leukotrienes. Studies have recently shown the role of vitamin D (vit.D) in many allergic and immune conditions, where receptors for the active form of vit.D (1,25-dihydroxyvitamin D3) have been discovered on the surface of almost all types of inflammatory cells. Therefore, the present study was conducted to explore the level of vit. D in AR patients and its correlation with the severity of the disease. Two groups participated in the study; the first group included 49 patients who were diagnosed in a private otolaryngology clinic by the first author as having allergic rhinitis (AR group). The second one served as a control group and included 50 apparently healthy volunteers with no history of AR. The mean level of IgE and vit. D was found to be 326.3 and 10.2 ng/ml in the AR group, respectively, and 30.8 and 23.3 ng/ml in the control group, respectively. Ninety-three percent of AR patients have shown a deficiency in vit. D level, where 56% of this group showed severe deficiency. On the other hand, 34% of the control group has shown an insufficient level of vit. D. Additionally, 64% of AR patients have shown serum levels of IgE at values ranging between 100-299 ng/ml. Higher serum levels of IgE at values ranging between 300-599 ng/ml and 600-1000 ng/ml were observed in 25% and 11% of AR patients, respectively. The prevalence of low levels of vit. D in the AR group was significantly higher than that in the control group (P < 0.001). Vit. D deficiency is significantly related to severe AR symptoms and measuring serum vit. D level is recommended in the management plan of this group of patients.
The Role of Polysomnography in Identifying Sleep Disorders in Children with Migraine
Authors: Nita Smaranda Antonia ,   Clinical Neurosciences Department, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   Neurology Department, University Emergency Hospital, Bucharest, Romania,   Smaranda Antonia Nita MD, PhD student, University Emergency Hospital, 169 Splaiul Independentei, 050098, Bucharest, Romania E-mail: nita.smaranda@gmail.com, Phone: +40766214513, Teleanu Raluca Ioana ,   Clinical Neurosciences Department, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   Pediatric Neurology Department, “Dr. Victor Gomoiu” Children's Hospital, Bucharest, Romania, Bajenaru Ovidiu Alexandru ,   Clinical Neurosciences Department, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   Neurology Department, University Emergency Hospital, Bucharest, Romania
Published: November 2022

Migraine pathophysiology and sleep share common neural pathways, and there are clinical as well as paraclinical observations, which lead to the hypothesis of an association between migraine and sleep disorders.

The objective of this study consisted of the evaluation of a possible correlation between migraine and sleep disorders in children, as reflected by sleep architecture and electroencephalographic patterns.

Eighteen patients aged five to seventeen were recruited for the migraine group, and sixteen age-matched patients with no criteria for migraine or any underlying organic disorder, diagnosed with emotional disorders, were enrolled in the control group. All patients underwent inpatient full night polysomnographic recordings, the results of which were analyzed using appropriate statistical methods.

Patients in the migraine group had decreased REM sleep (p = 0.049) and increased N1 sleep (p = 0.018) percentages, compared to the control group. Also, more arousals (p = 0.011) and lower sleep latency (p = 0.029) were noted in the migraine group. A statistically significant association was observed between migraine and sleep disorders when the latter was defined with respect to normal values of polysomnographic parameters published in studies conducted on healthy children.

Polysomnography can be a useful tool for studying sleep in pediatric migraine patients. The results of this study can be regarded as a starting point for a better understanding of the complex role of sleep in the developing brain and of eventual intricacies with migraine pathophysiological mechanisms.
Clinical Characteristics and Outcomes of Patients with Intracerebral Hemorrhage – A Feasibility Study on Romanian Patients
Authors: Alexandru Radu Razvan ,   Department of Neurology, University Emergency Hospital, Bucharest, Romania,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Oana Terecoasa Elena ,   Department of Neurology, University Emergency Hospital, Bucharest, Romania,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   Elena Oana Terecoasa, MD, PhD, Splaiul Independentei 169, 050098, Bucharest, Romania. E-mail: oana_ter@yahoo.com. Phone: 400213180522, Tiu Cristina ,   Department of Neurology, University Emergency Hospital, Bucharest, Romania,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Ghita Cristina ,   Department of Neurology, University Emergency Hospital, Bucharest, Romania, Irina Purcaru Larisa ,   Department of Neurology, University Emergency Hospital, Bucharest, Romania, Nicoleta Marinescu Andreea ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   Department of Radiology and Medical Imaging, University Emergency Hospital, Bucharest, Romania, Alexandru Bajenaru Ovidiu ,   Department of Neurology, University Emergency Hospital, Bucharest, Romania,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
Published: November 2022

Intracerebral hemorrhage is a significant public health problem, as it is a disease associated with overwhelming mortality and disability. We performed a retrospective feasibility study of patients admitted with acute intracerebral hemorrhage in our department for four months. Our aims were to identify peculiarities of the risk factors, demographic and clinical characteristics of intracerebral hemorrhage patients from our population, to estimate a feasible recruitment rate for a larger prospective study of patients with intracerebral hemorrhage and to analyze and correct potential drawbacks in the methodology of a more extensive prospective study of patients with intracerebral hemorrhage hospitalized in our department. During the study period, we admitted 53 patients with intracerebral hemorrhage in our department. The mean age of the patients was 69.1 years, and 53% were men. Arterial hypertension was the most common etiologic factor leading to intracerebral hemorrhage. 50.01% of patients died during hospitalization, 31.19% were discharged with significant disability, and 18.8% had a favorable short-term outcome. Higher hematoma volumes, male sex, deep location of the hemorrhage, and age between 51 and 60 years were factors associated with an unfavorable short-term outcome.
Paraparesis and Disseminated Osteolytic Lesions Revealing Cholangiocarcinoma: A Case Report
Authors: Ilut Silvina ,   Department of Clinical Neurosciences, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania,   Neurology II Department, County Emergency Hospital, Cluj-Napoca, Romania,   Silvina Ilut, Neurology II Department, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania, 43 Victor Babes Street, Cluj-Napoca, 400162, Romania. E-mail: silvina.ilut@yahoo.com, Vacaras Vitalie ,   Department of Clinical Neurosciences, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania,   Neurology II Department, County Emergency Hospital, Cluj-Napoca, Romania, Rosu Paula ,   Department of Clinical Neurosciences, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania,   Neurology II Department, County Emergency Hospital, Cluj-Napoca, Romania, Muntiu Aurora ,   Department of Clinical Neurosciences, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania,   Neurology II Department, County Emergency Hospital, Cluj-Napoca, Romania, Dina Constantin ,   Department of Radiology “Ovidius” University, Faculty of Medicine, Constanta, Romania
Published: November 2022

Bone metastases in cholangiocarcinoma are uncommon. We report the case of a patient with disseminated osteolytic lesions who was admitted to the Neurology Department for progressive paraparesis. On the computed tomography examination, specific features for cholangiocarcinoma were described, confirmed later by the histopathological aspect of the bone lesions.
Significant Clinical Associations Between Exposure Type Factors and Recurrent Wheezing and Asthma in Children
Authors: Bogdan Raluca Daniela ,   Department of Pediatrics, Medicover Hospital, Bucharest, Romania, Rusu Lidia ,   Regional Center of Public Health, Iasi, Romania, Ioan Toma Adrian ,   Department of Neonatology, Life Memorial Hospital, Bucharest, Romania,   Department of Medico-Surgical and Prophylactic Disciplines, Faculty of Medicine, “Titu Maiorescu” University, Bucharest, Romania,   Adrian Ioan Toma Life Memorial Hospital,365 Calea Grivitei, Bucharest, Romania Phone: +40723188272 E-mail: atoma@medlife.ro, Nastase Leonard ,   Department of Neonatology, “Alessandrescu-Rusescu” National Institute of Mother and Child Health, Bucharest, Romania,   Department of Obstetrics-Gynecology and Neonatology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
Published: November 2022

The study aimed to identify certain factors related to family history, pathological conditions, or exposure-type that are significantly correlated with recurrent wheezing and/or asthma in children. One hundred nine children with recurrent wheezing and 44 children with asthma were studied in order to identify the degree of correlation of these conditions with familial history of asthma or atopy, child’s age group, gender, premature birth, perinatal asphyxia, neonatal infection, and antibiotic treatment during the neonatal period, history of atopy and obesity and histamine intolerance, nasopharyngeal bacterial colonization, pneumonia with bronchospasm. The clinical picture of these two diseases was also compared regarding the severity of exacerbations and their response to controller therapy. The medium age of children diagnosed with recurrent wheezing was significantly lower than those diagnosed with asthma (5.64 vs. 9.01 years; p<0.001). Inside the recurrent wheezing group, age distribution differed significantly from the asthma group (p-value <0.001). Atopy was the only pathological condition significantly associated with asthma (56.0%) when compared with the recurrent wheezing group (30.2%) with a relative risk value of 1.34 (p<0.004). For patients colonized with Staphylococcus aureus, the medium number of wheezing exacerbations was significantly higher (p<0.049). Approximately 91% of patients in the recurrent wheezing group and 71% from the asthma group responded to appropriate controller treatment. Our study showed a significant association between asthma and atopy, justifying the need to monitor asthma risk in a child with wheezing and atopy. Nasal carriage of Staphylococcus aureus proved to be significantly associated with the recurrence of wheezing in children.
The relationship between IgG and IgM levels and severity of symptoms in COVID-19 patients confirmed by rapid antigen test
Authors: AL-Ibraheemi Jasim Saeed Salman ,   College of Medicine, University of Al-Ameed, Karbala, Iraq,   Jasim Saeed Salman AL-Ibraheemi, College of Medicine, University of Al-Ameed, Karbala, Iraq. Phone: 009647801010887; E-mail: jasim0alibraheemi@gmail.com; jassimfamilymedicine@gmail.com, AL-Saeedi Abdul-Sattar ,   Basic and Medical Sciences Branch, College of Nursing, University of Al-Ameed, Karbala, Iraq
Published: November 2022

This study aims to measure immunoglobulin G (IgG) and immunoglobulin M (IgM) response after detection of Severe Acute Respiratory Syndrome coronavirus (SARS CoV-2) antigens in coronavirus disease 2019 (COVID-19) patients concerning the severity of symptoms. SARS CoV-2 antigen was confirmed by rapid antigen test, and IgG and IgM were confirmed by VIDAS® SARS-COV-2 IgM and VIDAS® SARS-CoV-2 IgG automated qualitative assays used to rapidly detect antibodies 20–30 days after detection. The serological assay for detecting SARS-CoV-2 IgM and IgG antibodies shows a positive correlation for all patients detected with SARS-CoV-2 antigen with sensitivity 100% with differences in antibodies levels between patients regarding age and significantly related clinical symptoms with p-value 0.013 <0.05. The appearance of clinical symptoms was not significantly related to IgG levels at a p-value of 0.4 >0.05. However, the appearance of clinical symptoms was significantly related to IgM levels at a p-value of 0.002 <0.05. Antigen-dependent rapid tests can be used to detect SARS-CoV-2 in an early stage of infection with high sensitivity and specificity. Moreover, this study shows the age groups 21–30 and 31–40 have a better response to SARS-CoV-2 infection.
Evaluation of immunohistochemical expression of stem cell markers (NANOG and CD133) in normal, hyperplastic, and malignant endometrium
Authors: Al-Kaabi Methaq ,   Pathology and Forensic Medicine Department, College of Medicine, Mustansiriyah University, Baghdad, Iraq,   Methaq Al-Kaabi, Pathology and Forensic Medicine Department, College of Medicine, Mustansiriyah University, Baghdad, Iraq. E-mail: Abdullah.anishm@gmail.com, Noel Khalida ,   Anatomy, Histology and Embryology Department, College of Medicine, Mustansiriyah University, Baghdad, Iraq, Al-Rubai Abdal-jabbar ,   Anatomy, Histology and Embryology Department, College of Medicine, Mustansiriyah University, Baghdad, Iraq
Published: November 2022

Cancer stem cells (CSC) are a potential cause for recurrence, metastasis, and resistance of tumors to different therapeutic modalities like hormonal radiotherapy and chemotherapy. We investigated two CSC markers (NANOG and CD 133) in normal, hyperplastic endometrium and endometrial carcinoma. A total of 93 formalin-fixed paraffin-embedded tissue blocks were used for immunohistochemical expression of NANOG and CD133 markers. NANOG expression was detected in 88.37% of endometrial carcinoma cases compared to 15% of the normal proliferative endometrium and 60% of hyperplasia cases. In endometrial carcinoma, high NANOG expression was significantly correlated with high grade, deep myometrial invasion, lymph node metastasis, and high stage with p-values (0.009, 0.005, 0.014, and 0.003, respectively). CD133 was positive in 76.74% of endometrial carcinoma cases, and it showed a significant correlation with deep myometrial invasion, positive lymph node, positive lymphovascular invasion, and high stage (p-values 0.003, 0.001, 0.003, and 0.013, respectively). Normal endometrium showed less expression of CD133 (only 5%) than hyperplasia and endometrial carcinoma with a statistically highly significant difference (p less than 0.0001). Hyperplastic cases with atypia expressed higher CD133 than those without atypia (6 out of 12 versus 3 out of 18). However, this difference was not statistically significant (p-value 0.111). The cancer stem cell markers NANOG and CD 133 are expressed in a high percentage in endometrial carcinoma compared to normal and hyperplasia and their expression is positively correlated with the aggressive behavior of the tumor. High expression of these two markers in apparently normal tissue around the tumor and in hyperplastic conditions with atypia suggests the possibility to use NANOG and CD133 expression as a diagnostic marker distinguishing dysplasia from reactive atypia. Therefore, inhibition of these markers can be a promising method to stop the progression of early cancers.
L-Carnitine effect on induced hyperlipidemia on premature rats: fertility profile
Authors: Karam Khalid Mohammed ,   College of Veterinary Medicine, University of Al-Qadisiyah, Al-Qadisiyah, Iraq,   Khalid Mohammed Karam, College of Veterinary Medicine, University of Al-Qadisiyah, Al-Qadisiyah, Iraq. E-mail: Khalad.karam@qu.edu.iq, Alebady Ahmed Saed ,   College of Veterinary Medicine, University of Al-Qadisiyah, Al-Qadisiyah, Iraq, Al-Nailey Khalil Gazar Chelab ,   College of Veterinary Medicine, University of Al-Qadisiyah, Al-Qadisiyah, Iraq, Al-Delemi Dhia Hussain Jassim ,   College of Veterinary Medicine, University of Al-Qadisiyah, Al-Qadisiyah, Iraq
Published: November 2022

This study was designed to investigate the effect of hypercholesterolemia on the reproductive performance of premature male rats and to evaluate the influence of L-Carnitine (CAR) in maintaining their fertility. Sixty rats were divided randomly into three groups. Control group (CG n=20 rats), cholesterol feeding group 1 (CFG1 n=20 rats) fed 1.5% cholesterol with diet for one month, and cholesterol feeding group 2 (CFG2 n=20 rats) fed 1.5% cholesterol with diet + CAR 150 mg/kg body weight (B.W.) given by water for one month. Results showed a significant increase in body weight of CFG1 compared with CG and CFG2. The lipid profile of CFG1 after one month of feeding cholesterol showed a significant increase in serum cholesterol and triglyceride compared with CG and with the group that watered by CAR and CFG2. Results of sperms parameters in CGF2 showed a significant increase in sperms count with sperms live percentage and a significant decrease in sperms abnormalities percentage compared with CGF1 and CG. The hormonal profile showed a significant decrease in serum testosterone levels in rats from CFG1 compared with CFG2 and CG. In conclusion, CAR is a powerful antioxidant that can maintain the parameters of sperms of hypercholesterolemic premature rats, which may enhance the fertilizing ability of subfertile rats that may occur due to hyperlipidemia.
Phytotherapy in obstetrics – therapeutic indications, limits, and dangers
Authors: Grigoriu Corina ,   Department of Obstetrics and Gynecology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania,   Department of Obstetrics and Gynecology, University Emergency Hospital, Bucharest, Romania, Varlas Valentin ,   Department of Obstetrics and Gynecology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania,   Department of Obstetrics and Gynecology, Filantropia Clinical Hospital, Bucharest, Romania, Călinescu Gina ,   Department of Obstetrics and Gynecology, University Emergency Hospital, Bucharest, Romania, Bălan Andra Magdalena ,   Department of Obstetrics and Gynecology, University Emergency Hospital, Bucharest, Romania, Bacalbașa Nicolae ,   Department of Obstetrics and Gynecology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, Gheorghe Consuela-Mădălina ,   Department of Marketing and Medical Technology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania,   Consuela-Mădălina Gheorghe, Department of Marketing and Medical Technology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. E-mail: consuela.gheorghe@umfcd.ro, Salmen Teodor ,   Doctoral School of Carol Davila University of Medicine and Pharmacy Bucharest, National Institute of Diabetes, Nutrition and Metabolic Diseases N. C. Paulescu, Bucharest, Romania, Zugravu Corina Aurelia ,   Department of Hygiene and Ecology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, Bohîlțea Roxana Elena ,   Department of Obstetrics and Gynecology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania,   Department of Obstetrics and Gynecology, University Emergency Hospital, Bucharest, Romania,   Roxana Elena Bohîlțea, Department of Obstetrics and Gynecology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. E-mail: r.bohiltea@yahoo.com
Published: November 2022

The wide access to varied, attractive, and aggressively promoted information can induce pregnant women to think that any form of complementary therapy can be a saving solution for a medical problem because these therapies are natural, therefore, harmless. Updated information from literature about indications, benefits, limits, and risks of phytotherapy in pregnancy was presented. Valuable therapeutic resources with proven clinical efficacy (evidence-based medicine) were presented for each trimester of pregnancy, during labor, postpartum, but also during breastfeeding. For some phytotherapeutics, there are scientific studies. There is also a detailed presentation about some possibilities for therapeutic errors, which should be avoided during pregnancy. Positive results of phytotherapy deserve to be known and applied by the obstetrician for the certain benefit of future mothers.
Securitization of the Past in a Risk Society: a socio-philosophical analysis
Authors: Anikin Daniil Aleksandrovich , Konakov Dmitrii Nikolaevich
Published: November 2022

The article examines the concept of securitization from the point of view of social philosophy, determines the need to abandon objectivism or extreme constructivism in the analysis of this concept. The prerequisites for the formation of the security value are analyzed, as well as the main forms of securitization common in modern risk society, in particular, military, political, social, economic and environmental securitization. Special emphasis is placed on the study of the social conditions for the implementation of the securitization strategy. The object of the study is the phenomenon of securitization as a socio-philosophical phenomenon, and the subject of the study is mnemonic securitization as a new form of addressing the problem of security in a modern risk society. The author introduces the concept of securitization as a social practice based on the willingness of the community to perceive a certain natural or social phenomenon as an objectively existing threat. Mnemonic securitization is considered as a fundamentally new type of securitization, which presupposes the desire to present symbolically significant images of the past as an object of influence from ideological opponents. A special contribution to the problems of research is determined by the identification of links between the processes of transformation of collective communities and the emergence of risks of collective identity, which is expressed in the formation of ideas about the need for ontological security and the delegation of powers to protect this form of security by political actors, primarily the state.
Features of the conventional protection of cultural heritage at the level of the Council of Europe
Authors: Gibadullin Timur Damirovich
Published: November 2022

The aim of the work is to identify and disclose the distinctive features of the regulation of the protection of cultural heritage in accordance with the main conventions of the Council of Europe in this area, which are the subject of the study. The methodological basis of the article is the methods of deduction, induction, analysis, synthesis, formal-logical, descriptive, system-structural, historical, comparative, formal-legal methods. The paper identifies problems related to the protection of cultural heritage that exist on a global scale and at the level of Russia, describes the efforts of the international community to solve such problems. The definition of cultural heritage is given. The list of all international treaties adopted under the auspices of the Council of Europe, which in one way or another affect the issues of cultural heritage, is given, the greatest importance of five of these conventions is argued. The features of the conventional protection of cultural heritage at the level of this international organization, highlighted on the basis of the study of these international treaties, are considered. The author points out such features as paying special attention to human rights; attaching great importance to the participation of civil society and the public in activities related to cultural heritage; the frequent absence of its explicit division into tangible and intangible heritage, etc. Taking into account the highlighted characteristic features of the States parties to the most significant international treaties mentioned above can contribute to improving the effectiveness of their application of these conventions - not only individually, but also in a complex. This also applies to Russia. The author identifies areas related to the features of the convention protection of cultural heritage at the level of the Council of Europe, on which it may be advisable for Russia to intensify its activities. The scientific novelty of the article is determined by the above-mentioned conclusions and recommendations of the author. It is also expressed in the disclosure of some of the above-mentioned features of the regime of the main conventions of the Council of Europe in the field of protection of cultural heritage, for example, paying special attention to human rights.
PENGARUH AUDIT FEE, AUDIT TENURE, DAN FINANCIAL DISTRESS TERHADAP KUALITAS AUDIT
Authors: Wijaya Natasha , Susilandari Caecilia Atmini
Published: November 2022

This research aims to analyze the influence of audit fees, audit tenure, and financial distress on the audit quality of 30 property, real estate, and construction listed companies on Indonesia Stock Exchange in 2017-2020. Absolute discretionary accruals to detect earnings management are used to proxy audit quality. Audit fees are measured by the total fees paid to the auditor. Audit tenure is measured by total engagement between the auditor and the company. Financial distress is measured by the ratio of debt to equity. The analysis method used Multiple linear regression analysis with SPSS version 25. The result shows that audit fees are positively significant to audit quality. In contrast, audit tenure and financial distress are insignificant to audit quality.
COVID-19-related Myocarditis: Current Issue in Pandemic Situation
Authors: Surya Steven Philip , Santoso Rony Marethianto
Published: November 2022

Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a worldwide medical issue since it is easily transmitted from human to human. The human angiotensin-converting enzyme-2 (hACE2) expression gives access to SARS-CoV-2 through its affinity with the spike protein of SARS-CoV-2. Right after the patient has been infected with SARS-CoV-2, subsequently, it may lead to COVID-19 related myocarditis. However, there is still no practical guideline and it significantly affects morbidity and mortality status of COVID-19 patient. In this case report, we are showing challenges in diagnose and treat COVID-19 related myocarditis.

 Case presentation: A-45 years old man was referred to our hospital from Emergency Hospital for COVID-19 Kemayoran Athletes Village with typical chest pain. He felt a crushing sensation in his chest and it was intensifying every minute. The ECG examination showed ST-segment elevation in all precordial lead and inferior lead. His laboratory work revealed a significant increase of inflammation and cardiac troponin marker. His angiography examination came up with non-significant lesion. Unfortunately, biopsy couldn’t be done due to pandemic limitation. We were diagnosing the patient with COVID-19 related myocarditis and one week after treatment he was discharged from hospital. Currently, there were no diagnostic and treatment guideline for COVID-19 related myocarditis.

Conclusion: COVID-19 has become a novel glitch in medical practice situations. Not only lung, but it involves many other organs, and the heart is one of the most common organs involved. One of the cardiac complications of COVID-19 infection is COVID-19 related myocarditis. Currently, there is no guideline in diagnosing and treating COVID-19 related myocarditis and we are encouraging the international society to put an eye on it.
The Relationship Between Smartphone Addiction and Attention Among Medical Students at Atma Jaya Catholic University of Indonesia
Authors: Prasetyadi Amelia , Gustaman Lenny
Published: November 2022

Introduction: Smartphone addiction is characterized by a strong attachment to the smartphone that allows the occurrence of social problems and difficulty in performing everyday activities. Cognitive function disruption is one of smartphone addiction’s negative effects, and one component of cognitive function is attention. The prevalence of smartphone addiction in adolescents and young adults was higher since they were relatively more familiar to technology and lacked self-control. The purpose of this study is to determine the relationship between smartphone addiction and attention among medical students at Atma Jaya Catholic University of Indonesia.

Methods: An analytical, cross-sectional study was conducted with a total of 82 respondents. The respondents were from the 2016, 2017, and 2018 batch of medical students at Atma Jaya Catholic University of Indonesia and were selected by stratified random sampling. The data were gathered using Smartphone Addiction Scale Short Version (SAS-SV) questionnaire, in order to estimate the prevalence of smartphone addiction and the Stroop Test to measure attention.

Results. The majority of the subject were female (70,7%) and aged around 17-21 years. The respondents who were addicted to smartphones were 48,8%, and most respondents who were addicted were using their smartphone for 5-≤7 hours/day (63,3%) and spent their time more on social media (56,7%). The mean attention score was 63,81. The mean attention score for non-smartphone addicts was higher than the addicted ones, but there is no statistically significant correlation between smartphone addiction and attention (p= 0,06).

Conclusions. There is no significant correlation between smartphone addiction and attention.
The Relationship of Mother’s Knowledge, Attitude, and Behavior Regarding Diarrhea with the Number of Diarrhea Toddlers Taken to The Health Facility
Authors: Irin Irin , Kurniadi Angela
Published: November 2022

Introduction: Diarrhea is the second major cause of death in toddlers in developing countries, including Indonesia. The study aims to determine the relationship between knowledge, attitudes, and behavior of mothers regarding prevention and treatment of diarrhea with the number of toddlers taken to the health facility.

Methods: A cross-sectional study was involving 120 mothers who have a child with a history of diarrhea and were recruited using a simple random sampling method. Data were collected using demographic and diarrhea-related questionnaires. Fisher-Exact test was used to analyze data in univariate and bivariate with p-value ≤ 0,05 as the level of significance.

Results: Most of the mother’s knowledge, attitudes, and behavior regarding diarrhea were considered fairly good, with the percentage reaching 70,8%; 66,7%; 70,8%, respectively. However, knowledge, attitude, and behavior regarding giving ORS were low. There was a significant relationship between the attitude and behavior of the respondents with the number of diarrhea toddlers taken to health facilities (p = 0,010; p = 0,000), but there was no significant relation with the respondents’ knowledge (p = 0,065).

Conclusions: The attitude and behavior of mothers regarding diarrhea significantly affect the number of diarrhea toddlers taken to the health facility. Although the overall knowledge, attitude, and behavior of the mother were considered fairly good, but the knowledge, attitude, and behavior regarding giving ORS were low.

Keywords: knowledge – attitudes – behavior - diarrhea – toddlers - health facilities