bluuebunny/crossref_metadata_2025 huggingface dataset:
Molecular Dynamics Simulations of Two-Step Process Enable Room-Temperature Synthesis of α-FAPbI3
Authors: Ahlawat Paramvir , Lu Haizhou , Ummadisingu Amita , Niu Haiyang , Invernizzi Michele , Zakeeruddin Shaik M. , Hagfeldt Anders , Grätzel Michael , Rothlisberger Ursula , Parrinello Michele
Published: October 2020

It is well established that the lack of understanding the crystallization process in two-step sequential deposition has a direct impact on efficiency, stability and reproducibility of perovskite solar cells. Here, we try to understand the solid-solid phase transition occuring during two-step sequential deposition of methylammonium lead iodide and formamidinium lead iodide. Using metadynamics, X-ray diffraction and Raman spectroscopy, we reveal the microscopic details of this process. We find that the formation of perovskite proceeds through intermediate structures and report polymorphs found for methylammonium lead iodide and formamidinium lead iodide. From simulations, we discover a possible crystallization pathway for the highly efficient metastable α-phase of formamidinium lead iodide. Guided by these simulations, we perform experiments that results in the room temperature crystallization of α-formamidinium lead iodide.
Accurate and Rapid Prediction of pKa of Transition Metal Complexes: Semiempirical Quantum Chemistry with a DataAugmented Approach
Authors: Sinha Vivek , Laan Jochem Jan , Pidko Evgeny
Published: October 2020

Rapid and accurate prediction of reactivity descriptors of transition metal (TM) complexes is a major challenge for contemporary quantum chemistry. Recently developed GFN2-xTB method based on the density functional tight-binding theory (DFT-B) is suitable for high-throughput calculation of geometries and thermochemistry for TM complexes albeit with a moderate accuracy. Herein we present a data-augmented approach to improve substantially the accuracy of GFN2-xTB for the prediction of thermochemical properties using pKa values of TM hydrides as a representative model example. We constructed a comprehensive database for ca. 200 TM hydride complexes featuring the experimentally measured pKa’s as well as the GFN2-xTB optimized geometries and various computed electronic and energetic descriptors. The GFN2-xTB results were further refined and validated by DFT calculations with the hybrid PBE0 functional. Our results show that although the GFN2-xTB performs well in most cases, it fails to adequately desribe TM complexes featuring multicarbonyl and multihydride ligand environments. The dataset was analyzed with the partial least squares (OLS) fitting and was used to construct an automated machine learning (AutoML) approach for the rapid estimation of pKa of TM hydride complexes. The results obtained show a high predictive power of the very fast AutoML model (RMSE ~ 2.7) comparable to that of the much slower DFT calculations (RMSE ~ 3). The presented data-augmented quantum chemistry-based approach is promising for high-throughput computational screening workflows of homogeneous TM-based catalysts.
Visualized Degradation of Poly(alkynoate)s Toward Diols and Structure Controlled Multifunctional N-Heterocyclic Compounds
Authors: Song Bo , Bai Tianwen , Liu Dongming , Hu Rong , Lu Dan , Ling Jun , Qin Anjun , Tang Ben Zhong
Published: October 2020

Degradable polymers are highly desirable due to the tremendous growth of polymer wastes. Some polymers could be degraded under strong acidic or basic conditions toward unknown or unvalued products (i.e. downcycling). New methods to degrade polymers into monomers or high-value-added materials (i.e. upcycling) are more preferred for sustainable developments. In this work, linear and cross-linked poly(alkynoate)s were successfully degraded by benzamidine with 100% conversion into not only diols, a kind of monomers, but also high-value-added N-heterocyclic compounds of pyrimidone and imidazolone derivatives in high yields through controlling the reaction conditions. Notably, thanks to the AIE feature of the degraded products, the degradation process could be visualized under UV light via gradually increased luminescent intensity of the reaction mixtures, which facilitates the monitoring of the polymer degradation. Using this highly efficient degradation reaction, fluorescence patterns could be generated through microcontact printing (μCP) of the stamp on the thin films of poly(alkynoate)s. Moreover, the pyrimidone derivatives could be applied in bioimaging and inhibiting bacteria, and the imidazolone derivatives could be used for the detection and recovery of gold (III) ions from electronic waste and serve as the ﬂuorescent sensor to detect in situ generated amines from food spoilage. Thus, this work presents a visualized and high value product-selective degradation to solve the end-of-life issue of polymers.
Upper gastrointestinal bleeding in patients with stable coronary artery disease (registry of antithrombotic therapy “REGATТA” results)
Authors: Shakhmatova O. O. , Komarov A. L. , Korobkova V. V. , Yarovaya E. B. , Andreevskaya M. V. , Shuleshova A. G. , Panchenko E. P.
Published: October 2020

Introduction.Upper gastrointestinal (UGI) bleeding is a common complication of antiplatelet therapy. Data from real clinical practice that characterize the range of risk factors for UGI bleeding, prophylactic proton pump inhibitors (PPIs) therapy, bleeding frequency and their long-term effects in patients with stable coronary artery disease (CAD) are limited.
Aim.To identify predictors of UGI bleeding in patients with stable CAD, to assess the role of PPI in the prevention of bleeding and the long-term prognosis of patients after bleeding.
Materials and methods.934 patients with stable CAD (median age 61 [5368] years, 78.6% men) were included in the single institution prospective REGistry of Long-term AnTithrombotic TherApy (REGATTA). Atherosclerosis of peripheral arteries (APA) and abdominal aortic aneurysm (AAA) screening was performed by doctor decision, as well as esophagogastroduodenoscopy. 76% of patients received dual antiplatelet therapy for 612 months after elective PCI. PPIs were prescribed in 28.3% of cases.
Results.The median follow-up was 2.5 [1.15.1] years. The frequency of overt UGI bleeding was 1.9 per 100 patients per year. Anamnesis of peptic ulcer disease (OR 4.7; 95% CI 1.911.8;p=0.001), erosion of the upper gastrointestinal tract (OR 6.7; 2.716.6;p=0.00004 ), as well as concomitant diseases associated with a decrease in blood supply to the mucosa, such as heart failure HF (OR 6.1; 2.316.0;p=0.0002), AAA (OR 9.3; 2.534.2;p=0.0008) and APA (OR 2.3; 0.985.5;p=0.05) turned out to be independent predictors of UGI bleeding. The frequency of AAA among those who underwent UGI bleeding was 19.6% (in patients without bleeding 1.4%;p0.001). 90.2% of patients with UGI bleeding received PPI; the frequency of UGI bleeding in patients receiving pantoprazole and omeprazole did not differ significantly. After UGI bleeding, rebleeding rate was 7.8%, thrombotic events (TE) rate 31.4%, mortality rate 17.7% for 30 days, 19.4% for 1 year and 35.3% for the entire observation period. The predictors of deaths were AAA (OR 92.5; 7.7107.9;p0.0001), APA (OR 4.2; 1.0317.2;p=0.045) and HF (OR 34.5; 8.5140.6;p0.0001). The worst prognosis was expected for patients who underwent UGI bleeding and thrombotic events: 2/3 of these patients died.
Conclusion.In a prospective analysis of patients with stable CAD, we identified UGI bleeding was a significant risk factor for late thromboembolism and death, compared with patients without bleeding. Predictors of UGI bleeding and poor prognosis are factors that indicate atherothrombotic burden abdominal aortic aneurysm, peripheral atherosclerosis and HF. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT04347200.
The achievements of the modern specific therapy of pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: focus on the stimulator of soluble guanylate cyclase riociguat
Authors: Gratsianskaya S. E. , Valieva Z. S. , Martynyuk T. V.
Published: October 2020

Currently, treatment of pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) is focused on three signaling pathways: the NO pathway, the endothelin pathway, and the prostacyclin pathway. Riociguat is the only representative of stimulators of the soluble guanylate cyclase (sGC) class that is approved for the treatment of PAH and inoperable and persistent/recurrent CTEPH. The review presents data from clinical trials showing a positive effect of riociguat on the functional and hemodynamic profile of patients with PAH and CTEPH. In recent years there has been much discussion about the possibility of optimizing therapy by switching to drugs that affect a single pathogenesis target. Thus, sGC stimulants have obvious advantages over phosphodiesterase type 5 (PDE-5) inhibitors, including the ability of riociguat to exert pharmacological effects (due to a NO-independent mechanism of action) even in conditions of reduced NO production. Switching from PDE-5 to riociguat may be safe and appropriate, according to clinical trials presented in the review. In accordance with the guidelines for the diagnosis and treatment of pulmonary hypertension of the Eurasian Association of cardiologists from 2019, this strategy is approved when PDE5 therapy is ineffective in patients with PAH FC III (WHO).
COVID-19 and cardiovascular diseases
Authors: Chazova I. E. , Mironova O. I.
Published: October 2020

First cases of new coronavirus infection were registered in December 2019. The COVID-19 outbreak was declared a global pandemic. COVID-19 is much more dangerous for people older than 65. It is well known that cardiovascular diseases are more affecting older patients as well. The potentially dangerous combination of the new infection and different cardiovascular diseases has become a crucial problem of cardiology in 2020.
Nuevos Descriptores en Ciencias de la Salud para clasificar y recuperar información sobre equidad
Authors: Campos Ana Cristina Espíndola , Treuherz Arthur , Murasaki Renato Toshiyuki , Gonzalez Diego , Mújica Oscar J
Published: October 2020

El vocabulario Descriptores en Ciencias de la Salud (DeCS) establece un lenguaje único y común que permite la organización y facilita la búsqueda y recuperación de la literatura técnica y científica en salud disponible en las fuentes de información de la Biblioteca Virtual en Salud. El DeCS, creado por el Centro Latinoamericano y del Caribe de Información en Ciencias de la Salud (BIREME), un centro especializado de la Organización Panamericana de la Salud/Organización Mundial de la Salud (OPS/OMS), es la traducción y la extensión del vocabulario Medical Subject Headings (MeSH), mantenido por la National Library of Medicine de los Estados Unidos. BIREME, en coordinación con expertos de América Latina y el Caribe, ha incluido en el DeCS los temas de equidad, género, etnicidad y derechos humanos —temas transversales en el marco programático de la cooperación técnica de la OPS/OMS— para garantizar una mejor recuperación y uso de la información y evidencia científica relacionadas a estos temas. El objetivo de este artículo es describir el método de revisión terminológica del DeCS e informar los resultados obtenidos y los impactos de la ampliación terminológica en el área de equidad, que comprendió la inclusión de 35 nuevos descriptores.
Information Security in Agile Software Development Projects: A Critical Success Factor Perspective
Authors: Newton Nathan , Anslow Craig , Drechsler Andreas
Published: October 2020

© 27th European Conference on Information Systems - Information Systems for a Sharing Society, ECIS 2019. All rights reserved. The importance of information security in software development projects is long recognised, with many comprehensive standards and procedures in use to provide assurance of information security. The agile development paradigm conflicts with traditional security assurance by emphasising the delivery of functional requirements and a reduction in structured and linear development styles. Through a series of thirteen qualitative interviews, this study identifies practices that address this problem which have been successfully adopted by agile practitioners. The findings present four categories of practices - organisational, team, project, and technical - and twelve critical success factors that should be explicitly considered by practitioners to assure agile security. The critical success factors provide a foundation for practitioners to strategically identify and develop best practices to embed information security in agile development projects. The identified categories also highlight the importance of agile security practices centring around individuals and culture and contributes to the literature by providing a representation of agile security practices that encompasses a broad range of focal areas.
Occurrence and faecal shedding of extended-spectrum beta-lactamase-producing Escherichia coli in sows and their offspring
Authors: Vašek Jan , Vaňhara Jonáš , Dolejská Monika , Masaříková Martina , Čížek Alois , Smola Jiří
Published: October 2020

The aim of the present study was to monitor the presence of extended-spectrum beta-lactamase (ESBL) producing E. coli on farm A with the history of previous use of ceftiofur in suckling pigletsand to analyse the risk factors of selection and dissemination of ESBL producers in the production herd. In the year of 2014, a total of 411 samples (rectal swabs or faeces)from pigs of various age categories (sows, gilts and suckling piglets) were collected. The sampling was performed more than 24 months after the ban of ceftiofur on the farm.The sows and gilts were sampled repeatedly before and after farrowing. All collected samples were directly cultivated on MacConkey agar (MCA) containing cefotaxime (2 mg/l) and obtained sub-cultures were tested for ESBL production by double disc synergy test. According to our results, all gilts were negative for ESBL-producing E. coli in the introduction period, however, the excretion of ESBL-producing E. coli was observed before and after delivery. Most of the new-born piglets from positive sows and gilts shed ESBL-producing E. coli early after birth. All tested ESBL-producing isolates were resistant to multiple antimicrobials, suggesting that antibiotics from other groups used for therapy co-select for ESBL producers in pigs on the studied farm. Intestinal colonization of lactating sows and their offspring as well as survival of ESBL-producing E. coli in the farm environment should be recognised as important risk factors of circulation and long-time persistence of ESBL producers in the herd.
Computed tomographic findings in three Pinschers affected by incomplete ossification of the humeral condyle
Authors: Tamburro Roberto , Cerasoli Ilaria , Savino Rosaria , Terragni Rossella , Stehlík Ladislav , Vignoli Massimo
Published: October 2020

Incomplete ossification of the humeral condyle is a cause of forelimb lameness in dogs. Affected dogs are predisposed to humeral condylar fractures. Incomplete ossification of the humeral condyle has been reported in breeds such as Spaniel, Rottweiler, Labrador and Pug. Diagnosis is made by a radiographic or computed tomographic study of the elbow, while treatment includes the placement of a bone screw across the humeral condyle. This paper discusses the computed tomography findings of incomplete ossification of the humeral condyle in three Pinschers.
COALESCED ALGORITHM FOR SOLVING REACTIVE POWER PROBLEM
Authors: Lenin K.
Published: October 2020

This paper combines Parallel Chaos Optimization Algorithm with Outlook Algorithm (PO) to solve optimal reactive power problem. The algorithm is organized in dual phases. The first phase uses parallel chaos optimization grounded on tent map for global exploration, while outlook algorithm is involved in the second phase for local exploration. The projected PO algorithm has been tested in standard IEEE 57,118 bus test systems and simulation results show clearly the improved performance of the proposed PO algorithm in declining the real power loss when compared to other reported standard algorithms.
USERS' PERCEPTION REGARDING SCIENTIFIC PRODUCTION IN THE FACULTY OF MEDICAL SCIENCES
Authors: Daher Jorge Nader , Panunzio Amelia Patricia , Navarro Marlene Hernández
Published: October 2020

Higher Education Institutions in all regions must submit to internal and external evaluations carried out with transparency, carried out by independent experts. In the CEAACES evaluation model, research is included as one of the most important processes within university management. An evaluation was carried out at the University of Guayaquil in 2013, being evaluated in category “D”. The scientific production of the FCM was 2%, it ranked last in all the criteria, and it did not meet the requirements for accreditation, due to the tiny percentage that was maintained. Users' perception regarding scientific production is very important for the faculty of medical sciences.
Solar collectors integrated into transparent facades
Authors: Zhelykh Vasyl , Venhryn Iryna , Kozak Khrystyna , Shapoval Stepan
Published: October 2020

Due to the fact that the number of natural disasters in the world has increased in recent years, experts note that climate change is the cause. As a consequence of the nature of the needs to improve the fuel and energy complex in the countries in world. This solution could be solar energy and similar energy sources. The paper presents the classification of energy-efficient houses proposed by international standards and its critical analysis. Emphasis is placed on the problem of improving solar collectors integrated into the construction of buildings. The paper presents the temperature characteristics of an experimental solar collector. For the experimental solar collector combined with the translucent facade of the building, thermal characteristics are set, in particular, such as thermal capacity and thermal efficiency.
МОДЕЛЮВАННЯ ПРОЦЕСУ ТЕРТЯ В ТЕКСТИЛЬНИХ МАТЕРІАЛАХ
Authors: Супрун Н. П. , Рябчиков М. Л. , Іванов І. О.
Published: October 2020

Create a model for determining the coefficient of friction of textile materials to identify the main factors influencing the process of friction, taking into account the structural and mechanical properties of materials. Modeling of friction process in textile materials as a combination of adhesive and elastic phenomena. Roughness of solid bodies and the main parameters of roughness, such as the height of micro-irregularities, their pitch, sharpening, etc. described in many standards and scientific papers. However, the modeling of the friction process in such systems is very complicated due to the irregularity of distribution of microroughness. The analysis of literature data showed that the surface roughness of textile materials is an important and effective factor in predicting the tactile properties of products for various purposes. Estimation of surface roughness is usually carried out using subjective and objective methods, and the latter can be contact and non-contact. The paper develops a model for determining the coefficient of friction of textile materials to identify the main factors influencing the friction process, taking into account the structural and mechanical properties of materials. Friction force is presented as a combination of two main factors. The first is the elastic resistance to deformation, the second is the adhesive resistance to compression of the structural elements of the material. The main parameters influencing the coefficient of friction of textile fabrics - modulus of elasticity of structural elements, their geometrical parameters - surface density of textile material, linear density of structural elements are established. The obtained results allow to qualitatively predict the friction forces of a textile material with known parameters of its structural elements, as well as to normalize these parameters to create materials with specified friction indices. The obtained results make it possible to select the threads that form the textile material, according to the values of the modulus of elasticity, thickness, location density to ensure the minimum friction force.
Efficiency of SSR and PawS markers for evaluation of genetic polymorphism among red clover (Trifolium pratense L.) cultivars
Authors: Klimenko I. A. , Kostenko S. I. , Mavlyutov Yu. M. , Shamustakimova A. O.
Published: October 2020

Background. Identification of crop varieties is presently one of the most important aspects due a significant annual increase in the number of newly developed cultivars. Application of molecular markers makes it possible to identify cultivars and secure protection of plant breeders’ rights. Marker techniques based on SSR loci and PawS markers were evaluated for their efficiency in revealing the DNA polymorphism in Russian red clover cultivars, and the research results are presented in this publication.

Materials and Methods. The total genome DNA was extracted by a modified SDS method from 30 seedlings per each cultivar. Nine simple sequence repeats (SSR) and 4 PawS markers were used for genotyping. The basic genetic diversity parameters were measured and analyzed using the software resources GelAnalyzer 2010а, MStools v.3, and Statistica 7.0.

Results and conclusion. The mean level of intervarietal DNA polymorphism in red clover was 38.6%. Cultivar-specific amplicons were obtained for 4 accessions (cvs. ‘Trifon’, ‘Topaz’, ‘Trio’ and ‘Mars’) with SSR loci RCS1307 and RCS3095. These loci were found appropriate for identification and certification of such cultivars. The tested PawS markers (individually and in combinations) proved non-informative for the analysis of intervarietal DNA polymorphism in red clover. The only primer pair PawS5+PawS16 generated reproducible PCR products, but unique amplicons were absent in the DNA profiles. The data obtained in this study may be helpful for further identification and certification of Russian red clover cultivars and promising breeding materials.
Effective resistance to powdery mildew in Aegilops L. accessions
Authors: Kolesova M. A. , Chikida N. N. , Belousova M. Kh. , Tyryshkin L. G.
Published: October 2020

Background. Powdery mildew (Blumeria graminis (DC.) E.O. Speer f. sp. tritici Em. Marchal) is widespread and harmful in all regions of bread wheat cultivation. Severe development of powdery mildew leads to a decrease in the number and weight of grains. Growing resistant cultivars is the most environmentally friendly and economically profitable method to protect wheat from the disease. Development of such cultivars requires a search for new donors of effective genes controlling the resistance. To expand the genetic diversity of wheat for resistance to B. graminis, wild relatives of Triticum aestivum L., including Aegilops L. spp., are widely used. The aim of this work was to characterize seven Aegilops spp. for effective seedling and adult plant resistance to powdery mildew.

Materials and methods. The material of the study consisted of 437 accessions representing 7 Aegilops spp. (Ae. speltoides Tausch, Ae. caudata L., Ae. biuncialis Vis., Ae. tauschii Coss., Ae. cylindrica Host, Ae. crassa Boiss. and Ae. ventricosa Tausch) from the collection of the N.I. Vavilov All-Russian Institute of Plant Genetic Resources (VIR, St. Petersburg). Juvenile resistance was studied when the seedlings were inoculated with the agent of powdery mildew under controlled laboratory conditions; the adult plant resistance, after artificial inoculation of the plants and under natural infection in the fields of Pushkin and Pavlovsk Laboratories of VIR. Complex populations of the B. graminis agent were used for inoculation. The types of response to infection were scored 10 days after inoculation according to a conventional scale.

Results and conclusions. As a result of the tests, susceptibility to powdery mildew was shown in all Aegilops accessions of the D-genome group; all the studied representatives of Ae. speltoides, Ae. caudata and Ae. biuncialis were highly resistant to powdery mildew.
Sources of gray mold rot resistance in strawberries in the environments of the Middle Urals
Authors: Nevostrueva E. Yu.
Published: October 2020

Background. One of the most common diseases affecting garden strawberry fruits is gray mold rot. It is capable of destroying more than half of the fruit harvest in the wet seasons observed in the Middle Urals in recent years. Largesized marketable berries are the first to be affected. The disease does not entail the plant’s death, which is one of the probable reasons why this problem has not been studied much. Strawberry cultivars yielding firmer fruit are known to be less susceptible to gray mold damage, so they can be used as source material in breeding practice. There are few such accessions in the strawberry collection maintained at Sverdlovsk Horticultural Breeding Station, and those available, being of foreign origin, demonstrate poor winter hardiness, thus precluding their use in crosses as female parents. An assessment of the damage inflicted by gray mold rot on strawberry fruit may help to identify promising source material where gray mold resistance would be combined with a set of other commercially attractive traits.

Materials and methods. The evaluated material comprised 19 selected seedlings produced from crosses between source accessions that yielded berries of different firmness. Cv. ‘Festivalnaya’ served as the reference. The study was based on conventional techniques.

Results and conclusions. As a result of the evaluation for gray mold resistance, seedling 2-45-10 (Solovushka × Dukat) was identified as a promising female parent. When compared with the reference, this seedling manifested winter hardiness, high yield, and large size of berries. Seedlings 2-54-11 (Amulet × Marmolada) and 3-45-10 (Solovushka × Dukat), with the response to freezing scored 2.0, may be involved in crosses as male parents.
Genetic diversity assessment in pea cultivars and lines using the SSR analysis
Authors: Gainullina K. P. , Kuluev B. R. , Davletov F. A.
Published: October 2020

Background. Pea is the main leguminous crop in the Republic of Bashkortostan and widespread all over the world. The key role in the breeding of new pea cultivars is played by source material representing the phenotypic and genotypic diversity of Pisum sativum L., searched for in plant genetic resources collections. SSR markers are successfully used to study the DNA polymorphism of various genetic objects, including pea. However, the distribution of a number of microsatellite alleles in the genotypes of specific lines and cultivars of this valuable pulse crop remains practically unexplored.

Materials and methods. Molecular genetic polymorphism was studied in 40 pea cultivar accessions of different ecological and geographical origin from the Vavilov Institute’s genebank of plant genetic resources or developed at regional breeding centers. Microsatellite analysis was performed using 5 SSR markers from the genomic library of microsatellites (Agrogene®, France).

Results. All markers delivered good electrophoretic profiles and helped to amplify a number of alleles per locus varying from 2 (AB53) to 9 (AA355). The total number of alleles was 26, while the average number of alleles per locus was 5.2. The polymorphism information content (PIC) varied from 0.39 for locus AB53 to 0.82 for locus AA355, with the mean value of 0.60. The set of SSR markers used in the work made it possible to individualize each of the studied pea genotypes. The measured genetic distances were used to draw a dendrogram showing the distribution of genotypes according to their genetic relationship.

Conclusion. Through studying the source material for pea breeding by the SSR analysis the data were obtained that provide additional information about the genetic structure of the collection and the polymorphism of the studied cultivar accessions. The results of genotyping pea cultivars and lines can be used for their genetic identification or to select parental pairs for hybridization.
Descripción de las características clínicas y la respuesta a tratamiento en pacientes con miastenia grave sin timoma sometidos a timectomía en una institución de alta complejidad de Cali, Colombia, 2010-2017
Authors: Padilla Londoño Natalia , Martínez-Ruiz Diana , Sánchez Álvaro J. , Velásquez Mauricio
Published: October 2020

Introducción. La miastenia grave es una enfermedad autoinmunitaria con una prevalencia mundial de 150 a 250 casos por 1´000.000 de habitantes. El tratamiento recomendado para la miastenia grave sin timoma es la timectomía total, la cual es la única alternativa de curación.

Métodos. Se llevó a cabo un estudio descriptivo y retrospectivo de una serie de casos de pacientes adultos con miastenia grave sin timoma sometidos a timectomía, durante el periodo de 2010 a 2017. En el análisis estadístico descriptivo, se utilizaron frecuencias absolutas y porcentajes para las variables cualitativas y, para las variables cuantitativas, se utilizaron la mediana y el rango intercuartílico.

Resultados. Veintiocho pacientes con miastenia grave sin timoma se sometieron a timectomía desde el año 2010 hasta el 2017. Se categorizaron según la clasificación del estado posterior a la intervención de la Myasthenia Gravis Foundation of America y se evidenció que 4 (14,3 %) pacientes presentaban remisión completa y el grado 3 de manifestaciones clínicas mínimas fue el más frecuente en 19 (67,9 %); 26 (92,9 %) tuvieron mejoría con respecto al cambio del estado clínico, en 2 (7,1 %) no se documentaron cambios y en ningún paciente hubo empeoramiento, exacerbación o muerte secundaria a la enfermedad.

Conclusiones. A lo largo de siete años se practicó timectomía a 28 pacientes con diagnóstico de miastenia grave sin timoma, aproximadamente, en el 15 % de los pacientes hubo remisión completa, el grado 3 de manifestaciones mínimas fue el más frecuente y el 93 % presentó mejoría de su estatus clínico.
Infecciones del sitio operatorio posterior a mastectomía radical modificada, análisis epidemiológico en una clínica oncológica
Authors: García Posada Mara Judith , Mora Solano Estephannia , Maza Alicia , Hoyos Jorge Hernán
Published: October 2020

Introducción. La tasa de incidencia de infecciones del sitio operatorio asociadas a cirugías mamarias varía desde el 6 hasta el 38 %. Se presentan la incidencia local y el perfil microbiológico de las infecciones en una clínica oncológica. 

Métodos. Se trata de un estudio de cohorte, prospectivo, descriptivo, durante un periodo de un año en el Instituto Médico de Alta Tecnología, IMAT Oncomédica, de mujeres con diagnóstico de cáncer de mama, que presentaron infecciones del sitio operatorio después de la mastectomía.

Resultados. Se encontraron 335 cirugías registradas y la incidencia de infecciones del sitio operatorio fue del 3,38 %, todas en mastectomías radicales con reconstrucción. Se obtuvo crecimiento bacteriano en el 77 % de los cultivos, principalmente de cocos Gram positivos, con predominio de Staphylococcus aureus sensible a la meticilina (SAMS). Los bacilos Gram negativos representaron el 40 %. Se administraron cefalosporinas de primera generación como profilaxis antibiótica prequirúrgica, la cual fue correcta en el 31 % de los casos. En el 50 % de las pacientes infectadas se practicó el baño prequirúrgico y se cumplió el protocolo institucional.

Conclusiones. La incidencia encontrada de infecciones del sitio operatorio es menor que la reportada en otras series. Staphylococcus aureus sensible a la meticilina fue el microorganismo responsable más frecuente. El cumplimiento de la profilaxis con cefalosporina y baño prequirúrgico es fundamental para disminuir la incidencia de infecciones del sitio operatorio.
Bocio multinodular gigante. Revisión de la literatura a propósito de un caso
Authors: Causa Soteras Roberto Jesús , Causa García José Roberto , González Pérez Yilian Ayled
Published: October 2020

Introducción. La patología tiroidea abarca desde procesos benignos hasta cánceres. El manejo médico-quirúrgico del bocio gigante implica la realización de estudios citológicos y de imagen. El objetivo de este artículo fue hacer una revisión de la literatura y presentar un caso atendido de bocio multinodular gigante. Métodos. En el presente artículo se revisa la literatura sobre el tema en cuestión a propósito del caso de una paciente de 54 años de edad, intervenida quirúrgicamente por bocio multinodular, con evolución satisfactoria. Resultados. Se interviene la paciente de manera electiva, realizándo exéresis a un tiroides de 658 gramos, conservando los nervios laríngeos recurrentes y las glándulas paratiroides; se realizó una meticulosa hemostasia y se trasladó la paciente a la Unidad de Cuidados Intensivos. A los 3 días se retiraron ambos drenajes cervicales, y se dio alta hospitalaria definitiva a los 8 días. La biopsia por parafina corroboró el diagnóstico preoperatorio. Discusión. Las indicaciones de tratamiento quirúrgico del bocio incluyen: crecimiento rápido de la glándula, síntomas compresivos y sospecha de malignidad. Las complicaciones son mínimas cuando se realiza una técnica muy meticulosa. Conclusión. El bocio multinodular gigante es infrecuente, y en todos los casos, requiere de intervención quirúrgica.
Medalla al Mérito Institucional. Fundación Valle del Lili, Cali
Authors: Granados Marcela
Published: October 2020

La “Medalla al Mérito Institucional” de la Fundación Valle del Lili se otorga al médico del año, que se haya destacado por la excelencia en su compromiso con la institución, calidad humana, liderazgo, contribución al desarrollo, vocación de servicio, responsabilidad y relaciones interpersonales. Además, que cumpla a cabalidad con todos los valores de la Fundación, entre los cuales hay uno muy importante que es la integridad como persona, la cual nos lleva a que la ética sea un valor fundamental en todos nuestros colaboradores. Además, que al estar alineado con la estrategia de la Fundación, entregue mucho más, entregue innovación, creación, en procedimientos y en procesos, que lleven a la Fundación a estar al nivel nacional y latinoamericano en el que hoy nos encontramos.
Recomendaciones de la Academia Nacional de Medicina de Colombia para enfrentar los conflictos éticos secundarios a la crisis de COVID-19 en el inicio y mantenimiento de medidas de soporte vital avanzado
Authors: Castaño Yepes Ramón Abel , Arias Nieto Gloria , Borráez Gaona OOswaldo A. , Alejandro Nino Murcia Alejandro Nino Murcia , Liliana Támara Patiño Liliana Támara Patiño , Moreno Molina Julieta
Published: October 2020

CONTEXTO
La profesión médica, fiel a su compromiso de buscar el beneficio de los pacientes y lograr los mejores resultados posibles en el proceso de atención, respetando sus derechos y voluntad, se enfrenta al reto de la pandemia de COVID-19 y la consecuente situación de emergencia sanitaria, la cual conlleva un estado de excepcionalidad que modifica de manera fundamental algunos elementos tradicionales de la práctica médica.
MICRO-HARDNESS AND WEAR-RESISTANCE INVESTIGATION IN CARBO-METAL COATING COMPOSITES OBTAINED THROUGH GAS-DETONATION METHOD
Authors: Sil'chenko Ol'ga , Siluyanova Marina , Hopin Petr
Published: October 2020

The work purpose consists in the investigation of carbometal coatings wear-resistance and micro-hardness depending on chemical structure of their components. The investigation object is carbide-metal coatings. The result analysis of comparative wear-resistance tests witnesses that with micro-hardness increase in metal carbides of compositions: Cr3C2, WC, TiC, TiCN, at a constant content of cladding metal (30…35mass %), a value of wear decreases according to the linear law. Wear intensity of coatings of clad carbide mixtures with different materials is defined to a certain extent with wear intensity of material added to the matrix. In the course of the work there were developed coating compositions reinforced with quasi-crystals, there is defined an optimum composition and modes of coating application with the gas-detonation method and their wear-resistance and micro-hardness were investigated.
Mechanisms underlying the generation of autonomorespiratory coupling amongst the respiratory central pattern generator, sympathetic oscillators, and cardiovagal premotoneurons
Authors: Ghali Michael G. Z. , Ghali George Zaki , Lima Adriana , McDermott Michael , Glover Emma , Voglis Stefanos , Humphrey Jennifer , König Marton Skog Steinberger , Brem Henry , Uhlén Per , Spetzler Robert F. , Yasargil M. Gazi
Published: October 2020

The respiratory rhythm and pattern and sympathetic and parasympathetic outflows are generated by distinct, though overlapping, propriobulbar arrays of neuronal microcircuit oscillators constituting networks utilizing mutual excitatory and inhibitory neuronal interactions, residing principally within the metencephalon and myelencephalon, and modulated by synaptic influences from the cerebrum, thalamus, hypothalamus, cerebellum, and mesencephalon and ascending influences deriving from peripheral stimuli relayed by cranial nerve afferent axons. Though the respiratory and cardiovascular regulatory effector mechanisms utilize distinct generators, there exists significant overlap and interconnectivity amongst and between these oscillators and pathways, evidenced reciprocally by breathing modulation of sympathetic oscillations and sympathetic modulation of neural breathing. These coupling mechanisms are well-demonstrated coordinately in sympathetic- and respiratory-related central neuronal and efferent neurogram recordings and quantified by the findings of cross-correlation, spectra, and coherence analyses, combined with empirical interventions including lesioning and pharmacological agonist and antagonist microinjection studies, baroloading, barounloading, and hypoxic and/or hypercapnic peripheral and/or central chemoreceptor stimulation. Sympathetic and parasympathetic central neuronal and efferent neural discharge recordings evidence classic fast rhythms produced by propriobulbar neuronal networks located within the medullary division of the lateral tegmental field, coherent with cardiac sympathetic nerve discharge. These neural efferent nerve discharges coordinately evidence slow synchronous oscillations, constituted by Traube Hering (i.e., high frequency), Mayer wave (i.e., medium or low frequency), and vasogenic autorhythmicity (i.e., very low frequency) wave spectral bands. These oscillations contribute to coupling neural breathing, sympathetic oscillations, and parasympathetic cardiovagal premotoneuronal activity. The mechanisms underlying the origins of and coupling amongst, these waves remains to be unresolved.
A meta-analysis of case studies and clinical characteristics of hypertrophic olivary degeneration secondary to brainstem infarction
Authors: Wang Yi-Lin , Gao Yan , He Ping-Ping , Yin Jiang-Ning , Dong Ruo-Fei , Li Xin , Fu Yu , Zhang Hong
Published: October 2020

Transsynaptic degeneration in the cerebellum and brainstem may give rise to a rare neurological condition with various clinical manifestations, namely hypertrophic olivary degeneration. The classical manifestations of hypertrophic olivary degeneration comprise myoclonus, palatal tremor, ataxia, and ocular symptoms. Any lesions interrupting the dentate-rubro-olivary pathway, referred to as the anatomic Guillain-Mollaret triangle, contribute to the broad aetiologies of hypertrophic olivary degeneration. The clinical diagnosis depends primarily on the associated symptoms and the characteristic magnetic resonance imaging findings. Concerning treatment and prognosis, there are no widely accepted guidelines. Here, we identified 11 cases of hypertrophic olivary degeneration secondary to brainstem infarction from 1964 to the present. Combined with two of our cases, the clinical and imaging findings of 13 patients with hypertrophic olivary degeneration secondary to brainstem infarction were studied. A meta-analysis of case studies gives the correlation coefficient between infraction location and time to develop hypertrophic olivary degeneration as 0.217 (P = 0.393, P > 0.05). At the significance level of P < 0.05, there was no significant correlation between infraction location and time to develop hypertrophic olivary degeneration. The χ2 between infraction location and magnetic resonance imaging findings of hypertrophic olivary degeneration was 8.750 (P = 0.364, P > 0.05). At the significance level of P < 0.05, there was no significant correlation between infraction location and magnetic resonance imaging findings of hypertrophic olivary degeneration. Conclusion based on the analysis of available data suggests that when newly developed or progressive worsening motor symptoms are presented in patients with previous brainstem infarction, a diagnosis of hypertrophic olivary degeneration should be investigated.
Molecular and microstructural biomarkers of neuroplasticity in neurodegenerative disorders through preclinical and diffusion magnetic resonance imaging studies
Authors: Gatto Rodolfo Gabriel
Published: October 2020

Advances in the understanding of genetic and molecular mechanisms and imaging technologies have opened a new window of research possibilities to address dynamic processes associated with neuroplasticity in physiologically intact models of neurodegenerative diseases. This review aims to: (i) establish the most relevant molecular mechanisms, as well as cellular and structural biomarkers in the study of neuroplasticity; (ii) introduce different neurodegenerative diseases in animal models that contribute to our knowledge of neuroplasticity; and (iii) illustrate the capabilities and limitations of current diffusion magnetic resonance imaging techniques to study cortical plasticity, as well as the use of alternative diffusion models.
Current targets and drug candidates for prevention and treatment of SARS-CoV-2 (COVID-19) infection
Authors: Goyal Ramesh K. , Majeed Jaseela , Tonk Rajiv , Dhobi Mahaveer , Patel Bhoomika , Sharma Kalicharan , Apparsundaram Subbu
Published: October 2020

Angiotensin-converting enzyme 2 (ACE2), the host cell-binding site for SAR-CoV-2, poses two-fold drug development problems. First, the role of ACE2 itself is still a matter of investigation, and no specific drugs are available targeting ACE2. Second, as a consequence of SARS-CoV-2 interaction with ACE2, there is an impairment of the renin-angiotensin system (RAS) involved in the functioning of vital organs like the heart, kidney, brain, and lungs. In developing antiviral drugs for COVID-19, ACE2, RNA-dependent RNA polymerase (RdRp), and the specific enzymes involved in the viral and cellular gene expression have been the primary targets. SARS-CoV-2 being a new virus with unusually high mortality, there has been a need to get medicines in an emergency, and the drug repurposing has been a primary strategy. Considering extensive mortality and morbidity throughout the world, we have made a maiden attempt to discover the drugs interacting with RAS and identify the lead compounds from herbal plants using molecular docking. Both host ACE2 and viral RNA-dependent RNA polymerase (RdRp) and ORF8 appear to be the primary targets for the treatment of COVID-19. While the drug repurposing of currently approved drugs seems to be one strategy for the treatment of COVID-19, purposing phytochemicals may be another essential strategy for discovering lead compounds. Using in silico molecular docking, we have identified a few phytochemicals that may provide insights into designing herbal and synthetic therapeutics to treat COVID-19.
Over-expansion of second-generation drug-eluting stents, risk of restenosis, and relation to major adverse cardiac events
Authors: Yi Tao , Zhao Zi-Wen , Chen Liang-Long
Published: October 2020

The relationship between stent expansion conditions and clinical outcomes is not completely understood. This prospective cohort study included patients who were successfully implanted with second-generation drug-eluting stent in 2012 and received follow-up angiography in 9-12 months. Stent over-expansion was defined as ≥ 1.05 of the stented segment over the reference artery diameter. Imaging parameters were measured, and the follow-up period was 7 years. A total of 123 patients with 161 lesions were enrolled, and 75 (46.58%) stents were found to be over-expanded. The baseline clinical and procedural data were comparable. Stent over-expansion showed a markedly increased diameter stenosis percentage (DSP) at 1-year follow-up (24.12 ± 21.10% vs. 14.65 ± 16.75%, P = 0.002) and high late lumen loss (LLL) in-segment (0.54 ± 0.62 mm vs. 0.31 ± 0.55 mm, P = 0.014). Furthermore, 63 patients with ≥ 1 over-expanded stented lesions were classified into the over-expansion group. Cumulative major cardiac adverse event (MACE) was higher in the over-expansion group than the norm-expansion group (17.5% vs. 8.3%, P = 0.133). Target lesion revascularization/target vessel revascularization increased during the 7-year follow-up period in the over-expansion group compared with the norm-expansion group (11.1% vs. 3.3%, P = 0.098). The Kaplan-Meier cumulative MACE-free survival showed a better tendency for statistical differences in the norm-expansion group than in the over-expansion group (log-rank test; P = 0.083). Conclusion: Stent over-expansion is associated with a significant increase in LLL and DSP at 1-year angiographic follow-up and with the increasing trend of cumulative MACE during 7-year clinical follow-up period compared with stent norm-expansion. Stent over-expansion needs to be avoided.
Laporan minggu ke 3 keg. 6
Authors: nurliani
Published: October 2020

Kuliah kerja lapang plus (kklp) merupakan suatu kegiatan perkuliahan yang bersifat intakurikuler dalam bentuk pengabdian pada masyarakat yg di lakukan oleh mahasiswa dalam jangka waktu tertentu. Oleh karena, sifatnya intrakurikuler sehingga setiap mahasiswa yang akan menyelesaikan studi di perguruan tinggi pada suatu program Strata satu (S1) harus mengikuti Kklp.
Strategi Perintisan Jemaat terhadap suku dayak dalam Adat Buromak di Kacamatan Noyan
Authors: Anas Nopi
Published: October 2020

Tujuan dari penulisan ini adalah untuk menganalisis sebuah adat Buromak Suku Dayak Bisomu sebagai strategi Kontekstualisi pemberitaan Injil keselamatan yang berasal dari Allah. Pengkajian aspek arti dan nilai budaya Buromak dengan kepala adat, dalam strategi penerapan Injil dalam perintisan Jemaat melalui adat Buromak, tentang keselamatan dalam konteks kehidupan masyarakat suku dayak Bisomu. Melalui adat Buromak dengan kepala adat di suku dayak Bisomu, Kecamatan Noyan akan memberikan makna dan jalan untuk menuju pemberitaan Injil bagi suku Dayak Bisomu untuk mengenal Yesus Kristus sebagai Tuhan dan Juruselamat yang hidup dalam Suku Dayak Bisomu serta representasi hubungan Allah dan orang-orang percaya. Dengan buromak dan kepala adat dapat mempermudah dalam mengkomunikasikan hubungan Allah dengan umat ciptaan-Nya, kasih Allah terhadap orang-orang percaya, Suku Dayak Bisomu dapat merasakan damai sejahtera yang berasal dari pada Allah dan dapat menaruh kepercayaan kepada Tuhan. Peneguhan hubungan Allah dengan umat-Nya telah diwujudkan melalui Kristus Yesus, yang mati dikayu Salib untuk menyelamatkan manusia dari dosa serta memulihkan manusia dari segala sakit penyakit.
Laporan Keenam Minggu Ketiga KKLP Posko Bontonompo
Authors: ibrahim irma devina
Published: October 2020

Kuliah Kerja Lapang Plus (KKLP) merupakan suatu kegiatan perkuliahan yag bersifat intrakurikuler dalam bentuk pengabdian pada masyarakat yang dilakukan oleh mahasiswa dalam jangka waktu tertentu. oleh karena, sifatnya intrakurikuler sehingga setiap mahasiswa yang akan menyelesaikan studi di perguruan tinggi pada suatu Program Strata Satu (S1) harus mengikuti KKLP.
Laporan minggu 2
Authors: Mustari
Published: October 2020

Seminar dilakukan untuk mengenalkan program kerja kami pada masyarakat
Laporan Minggu 2
Authors: Nur Akbar
Published: October 2020

Seminar program kerja adalah kegiatan untuk memberitahukan ke masyarakat tentang program kerja kami pada masyarakat