bluuebunny/crossref_metadata_2025 huggingface dataset:
MSME Taxpayer Morality and Awareness in Fulfillment of Obligations in Pandemic Times
Authors: Purnamawati I Gusti Ayu , Yuniarta Gede Adi , Herliyani Elly
Published: February 2023

The negative growth in tax revenues was caused by slowing economic activity and fiscal incentives, especially in the MSME sector affected by the pandemic. This research effort analyzes the aspects of morality and awareness of taxpayers towards tax obligations through the development of attribution theory. The quantitative approach through this research uses 250 respondents who own MSMEs. The analysis model uses multiple linear regression with random sampling to collect data. Primary data collection uses a questionnaire through the form of google form. The study results found that the morality and awareness of taxpayers affected the fulfillment of their obligations during the pandemic period. So that the government in determining the direction of policies related to compliance such as improving services in the field of socialization to taxpayers so that they understand more about taxation and have an effect on increasing the intention to carry out tax obligations and making policies according to the conditions and abilities of the community. Taxpayer compliance, in this case, is very necessary, which leads to how taxpayers are obedient to tax rules.
Modified atmosphere packaging maintains the postharvest quality of baby mustard (Brassica juncea var. gemmifera)
Authors: Sun Bo , Di Hong-Mei , Lin Pei-Xing , Wang Gui-Yuan , Li Zhi-Qing , Wang Ya-Ting , Fang Peng-Cheng , Cui Ce-Xian , Zhang Fen , Zheng Yang-Xia
Published: February 2023

Baby mustard has increased in popularity among consumers. However, baby mustard is highly perishable. In this study, the influence of various modified atmosphere packaging (MAP) on the visual quality and content of soluble sugars and glucosinolates of baby mustard during postharvest storage was studied. Baby mustard was packed in no holes (M0), microholes (M1), or macroholes (M2) polyethylene bags respectively, and then stored at 20 °C. M1 and M2 inhibit the deterioration of visual quality of baby mustard, maintained the glucosinolates content, as well as prolonged the shelf life compared with non-wrapped plants, and M2 was the most effective in delaying the decline in visual parameters. By contrast, M0 accelerated the deterioration of postharvest quality. These findings indicate that M2 provides a promising approach for maintaining the visual and nutritional quality of postharvest baby mustard at ambient temperature.
Physiological responses of two equine breeds to a tropical winter climate
Authors: Leonel Avendaño-Reyes , Guadalupe Miranda-Ojeda Marianne , Arturo César García-Casillas , Rafael Julio Macedo-Barragán , María Isabel Carrillo-Díaz , María Isabel Carrillo-Díaz , Alberto Ruíz-Ramírez Johnatan , Rivera Juan Augusto Hernández
Published: February 2023

In tropical regions of Mexico, breed horses introduced from European countries are used for recreational activities under hot and humid conditions without considering their well-being. In order to evaluate the effect of winter conditions on physiological responses of two equine breeds, twelve horses (six Spanish and six Friesian breeds) were evaluated in the western Pacific coast of Mexico. The winter season was divided in 3 periods so that the statistical model included the factors breed and period. The physiological responses evaluated were: heart rate (HR), respiratory rate (RR), capillary refill time (CRT), and rectal temperature (RT). The climatic variables ambient temperature (AT) and relative humidity (RH) were used to estimate the temperature-humidity index (THI). Averages for THI, AT and RH were 71.4 units, 24.3 °C, and 53.4%, respectively. The CRT was similar (P > 0.05) among breeds and periods. The interaction B X P was significant (P < 0.05) for HR, RR, and RT in the second and third periods, but not in the first one. As a result, Spanish horses experimented higher (P < 0.05) HR (38.1 vs 37.6 and 38.0 vs 37.0 beats/min), RR (18.8 vs 18.5 and 18.9 vs 17.4 bpm), and RT (38.1 vs 38.0 °C and 38.0 vs 37.8 °C) than Friesian horses during the second and third periods, respectively. Both breeds of horses were exposed to a mild to moderate heat stress during winter tropical conditions; however, Spanish breed horses showed better tolerance to heat stress than Friesian horses based on their physiological measures evaluated.
Comparison of Prices for Commonly Administered Drugs in Employer-Sponsored Insurance Relative to Medicare
Authors: Chang Jessica Y. , Sen Aditi P.
Published: February 2023

This cross-sectional study compares unit prices and price growth in employer-sponsored insurance and Medicare over 2016 through 2020 for physician-administered drugs with the highest use and those with the highest spending.
Core Recommendations for Osteoarthritis Care: A Systematic Review of Clinical Practice Guidelines
Authors: Conley Brooke , Bunzli Samantha , Bullen Jonathan , O'Brien Penny , Persaud Jennifer , Gunatillake Tilini , Dowsey Michelle M. , Choong Peter F. M. , Lin Ivan
Published: February 2023

Objective

To evaluate the quality of clinical practice guidelines (CPGs) for interventions in management of osteoarthritis (OA) and to provide a synthesis of high‐quality CPG recommendations.

Methods

Five databases (OvidSP Medline, Cochrane, Cumulative Index to Nursing and Allied Health Literature [CINAHL], Embase, and the Physiotherapy Evidence Database [PEDro]) and 4 online guideline repositories were searched. CPGs for the management of OA were included if they were 1) written in English and published from January 2015 to February 2022, focused on adults age ≥18 years, and met the criteria of a CPG as defined by the Institute of Medicine; and 2) were rated as high quality on the Appraisal of Guidelines for Research and Evaluation II (AGREE II) instrument. CPGs for OA were excluded if they were available via institutional access only, only addressed recommendations for the system/organization of care and did not include interventional management recommendations, and/or included other arthritic conditions.

Results

Of 20 eligible CPGs, 11 were appraised as high quality and included in the synthesis. Of interest were the hip, knee, hand, and glenohumeral joints and/or polyarticular OA. Consistent recommendations were that care should be patient centered and include exercise, education, and weight loss (where appropriate). Nonsteroidal antiinflammatory drugs and surgical interventions were recommended for disabling OA that had not improved with nonsurgical care. Hand orthoses should be recommended for patients with hand OA.

Conclusion

This synthesis of high‐quality CPGs for OA management offers health care providers with clear, simple guidance of recommended OA care to improve patient outcomes.
Perspectives on Treatment Burden for Methotrexate and Tumor Necrosis Factor Inhibitors Among Patients With Psoriatic Arthritis and Rheumatoid Arthritis: A Qualitative Study
Authors: Ogdie Alexis , Shaw Yomei , Almonte Michele , Maksabedian Hernandez Ervant J. , Stolshek Bradley , Michaud Kaleb
Published: February 2023

Objective

To describe patients’ perspectives on the burden associated with methotrexate (MTX) or tumor necrosis factor inhibitor (TNFi) use in psoriatic arthritis (PsA) and rheumatoid arthritis (RA).

Methods

Between May 2019 and March 2020, patients receiving MTX and/or a TNFi for either PsA or RA were randomly sampled from the FORWARD data bank and were invited to participate in semistructured telephone interviews. Interviews explored patients’ perspectives on treatment burden and experiences with MTX and TNFi and were conducted until data saturation was achieved. Interviews were recorded, transcribed, and analyzed using a grounded theory approach and NVivo v12.0 software.

Results

Overall, 25 patients with PsA and 24 patients with RA participated in the interviews. Participants were predominantly women (mean age: 67 years). Nine major themes related to treatment burden were explored, including treatment side effects and their management, psychological burden, effect on daily functioning and work participation, challenges with accessing and administering therapies, financial difficulties or economic impact, and family planning or breastfeeding. Patients receiving MTX mostly reported side effects as the major burden, while cost and concerns with accessing and administering medication were major challenges reported by TNFi users. Treatment discontinuation due to lack of effectiveness was high for PsA, while discontinuation due to medication cost was high for RA.

Conclusion

Patients experience a wide range of burden associated with treatments used for PsA and RA. Health care practitioners should consider these challenges when prescribing therapy and strive toward reducing this burden by understanding patients’ concerns and needs and involving them in decision making.
IC&RC on SOTU message: Support SUD professionals
Authors: Knopf Alison
Published: February 2023

On Feb. 7, President Biden in his State of the Union (SOTU) address cited the importance of substance use disorder (SUD) professionals. “We also need more first responders and other professionals to address growing mental health and substance abuse challenges,” the President declared.
Dual Mode Strain–Temperature Sensor with High Stimuli Discriminability and Resolution for Smart Wearables
Authors: Xiao Huiyun , Li Shengbin , He Zidong , Wu Yuanzhao , Gao Zhiyi , Hu Chao , Hu Siqi , Wang Shengding , Liu Chao , Shang Jie , Liao Meiyong , Makarov Denys , Liu Yiwei , Li Run‐Wei
Published: February 2023

Strain and temperature are important physiological parameters for health monitoring, providing access to the respiration state, movement of joints, and inflammation processes. The challenge for smart wearables is to unambiguously discriminate strain and temperature using a single sensor element assuring a high degree of sensor integration. Here, a dual‐mode sensor with two electrodes and tubular mechanically heterogeneous structure enabling simultaneous sensing of strain and temperature without cross‐talk is reported. The sensor structure consists of a thermocouple coiled around an elastic strain‐to‐magnetic induction conversion unit, revealing a giant magnetoelastic effect, and accommodating a magnetic amorphous wire. The thermocouple provides access to temperature and its coil structure allows to measure impedance changes caused by the applied strain. The dual‐mode sensor also exhibits interference‐free temperature sensing performance with high coefficient of 54.49 µV °C−1, low strain and temperature detection limits of 0.05% and 0.1 °C, respectively. The use of these sensors in smart textiles to monitor continuously breathing, body movement, body temperature, and ambient temperature is demonstrated. The developed multifunctional wearable sensor is needed for applications in early disease prevention, health monitoring, and interactive electronics as well as for smart prosthetics and intelligent soft robotics.
N−H Trifluoroethylation of Indoles and other Aromatic N‐Heterocycles with CF3CHCl2 by Copper‐Mediated Cross‐Coupling Reaction
Authors: Deng Zhen , Qiu Liu‐Yan , Chen Jie , Zhang Hui , Cao Weiguo , Tang Xiao‐Jun
Published: February 2023

The Cu‐mediated N−H trifluoroethylation of NH‐containing heteroaromatic compounds with the CF3CHCl2 (HCFC‐123), commercially available in industrial scale, has been achieved. This method can be applied to various NH‐containing heteroaromatic compounds including indoles, pyrroles, pyrazoles and carbazoles. Furthermore, this protocol allows the late‐stage trifluoroethylation of NH‐containing heteroaromatic bioactive‐molecules.

magnified image
The Rapid Mechanochemical Synthesis of Microporous Covalent Triazine Networks: Elucidating the Role of Chlorinated Linkers by a Solvent‐Free Approach
Authors: Krusenbaum Annika , Kraus Fabien Joel Leon , Hutsch Stefanie , Grätz Sven , Höfler Mark Valentin , Gutmann Torsten , Borchardt Lars
Published: February 2023

The mechanochemical synthesis of porous covalent triazine networks (CTNs), exhibiting theoretically ideal C/N ratios and high specific surface areas, is presented. Employing this solvent‐free approach allows to minimize the ecological impact of the synthesis by bypassing hazardous wastes, while simultaneously observing the reactions between the individual starting materials separately for the first time. Especially the role of dichloromethane needs to be reconsidered, functioning as a linker between the nitrogen‐containing node cyanuric chloride and the aromatic monomer 1,3,5‐triphenylbenzene, as proven by X‐ray photoelectron spectroscopy and 1H → 13C Cross‐Polarization magic‐angle‐spinning nuclear magnetic resonance spectroscopy. This results in a drastic enhancement of the reaction rate, reducing the synthesis time down to 1 minute. Additionally, this linkage over a C1 bridge enables the incorporation of nitrogen into already synthesized polymers by post polymerization functionalization. The variation of the synthesis building blocks, namely the linker, node, and monomer, results in a variety of nitrogen‐containing polymers with specific surface areas of up to 1500 m2 g−1. Therefore, the presented approach is capable to target the synthesis of various CTNs with a minimal use of chlorinated linker, rendering the concept as a sustainable alternative to the classical solution‐based synthesis.
Brain Capillary‐Inspired Self‐Assembled Covalent Organic Framework Membrane for Sodium–Sulfur Battery Separator
Authors: Chen Sifan , Liang Lijun , Li Yuanyuan , Wang Dongyun , Lu Jianguo , Zhan Xiaoli , Hou Yang , Zhang Qinghua , Lu Jun
Published: February 2023

Room‐temperature sodium–sulfur (RT/Na–S) batteries are a promising low‐cost energy storage technology. However, the vital role of the separator in the system is often overlooked. Inspired by the maintenance of brain homeostasis by human brain capillaries, this work pioneers a host–guest self‐assembled strategy for covalent organic scaffold membranes, endowing the membrane with multiple functions (sodium ion transport, confinement, and conversion of polysulfides) to maintain the stability of the RT/Na–S battery system. The free‐standing multifunctional covalent organic framework membrane (HB/CNT@COF) maximizes the roles of the host framework and guest molecules. Because of the synergistic effect of hydroxynaphthol blue (HB) and multiwalled carbon nanotubes (CNT), the HB/CNT@COF cell exhibits a capacity of 733.4 mAh g−1 with limited capacity fading after 400 cycles at 4 C. This performance is nearly four times that of commercial glass fiber separators. Additionally, the cell demonstrates excellent performance under electrolyte‐poor conditions.
Operating Principle and Device Configuration Driven Mechanisms in Low‐Dimensional Materials for Neuromorphics
Authors: Ahmed Taimur , Krishnamurthi Vaishnavi , Mitchell Arnan , Walia Sumeet
Published: February 2023

The alluring electronic, optoelectronic, and photonic properties of low‐dimensional materials have allowed brain‐inspired electronics to evolve in unprecedented ways. With highly efficient neuromorphic devices and architecture being concocted lately, an understanding of the underlying device mechanisms has emerged. The question of what types of materials and physical mechanisms will be used in future neuromorphic hardware is still open for debate. Herein, a critical review of the mechanisms among various configurations in state‐of‐the‐art low‐dimensional neuromorphic devices is presented. The factors are also reviewed that influence the working paradigm of low‐dimensional neuromorphic devices under different stimuli. Finally, a forward‐looking outlook on the challenges and perspectives in analyzing the mechanisms in this emerging research direction to drive next‐generation neuromorphic computing is provided.
Recent Advances in Perceptive Intelligence for Soft Robotics
Authors: Lin Zhuofan , Wang Ziya , Zhao Wenyu , Xu Yingtian , Wang Xiaopu , Zhang Tianwei , Sun Zhenglong , Lin Lan , Peng Zhengchun
Published: February 2023

Over the past decade, soft robot research has expanded to diverse fields, including biomedicine, bionics, service robots, human–robot interaction, and artificial intelligence. Much work has been done in modeling the kinematics and dynamics of soft robots, but closed‐loop control is still in its early stages due to limited sensory feedback. Thanks to the advancement in functional materials, structures, and manufacturing techniques for flexible electronics, flexible and stretchable sensors are developing rapidly. These sensors provide feedback for closed‐loop control tasks and enable soft robots to effectively explore the unknown and safely interact with humans and the environment. Herein, recent advances in perceptive soft robots that utilize flexible/stretchable sensors and functional materials are outlined. The perceptive functions of soft robots from two different aspects, that is, proprioception and exteroception, are summarized. Furthermore, the constructions of autonomous soft robots by integrating both proprioceptive and exteroceptive capabilities for closed‐loop control tasks and other challenging tasks in the real world are discussed.
Bio‐Inspired Morphological Evolution of Metastructures with New Operation Modalities
Authors: Zhang Qianyun , Barri Kaveh , Yu Hao , Wan Zhe , Lu Wenyun , Luo Jianzhe , Alavi Amir H.
Published: February 2023

Harnessing the power of natural evolution for automated exploration of novel forms of metastructures is likely to be the next technological revolution of the material science. Herein, the principles of evolution into the metamaterial design and discovery process to directly evolve thousands of metastructures with hitherto‐unknown structures and new modalities of operation are embedded. In this so‐called evolving metamaterial (EM) concept, evolution takes place by randomly creating an initial population of parent metamaterial entities that pass on their genetic material to their offspring through variation, reproduction, and selection. The metamaterial configurations with desired response emerge during this evolutionary process. The EM concept presents a different approach for direct morphological evolution of metamaterial microstructures using merely a piece of matter. For the biologically inspired evolution of mechanical metamaterials, this piece is chosen to be a representative unit cell to launch the design process. This paradigm shift by creating an evolutionary computational framework for the exploration of a series of proof‐of‐concept 2D mechanical metamaterial structures with maximum bulk modulus, maximum shear modulus, and minimum Poisson's ratio is studied. The capability of the proposed approach for discovering 3D is examined by exploring a suite of 3D configurations with maximum bulk modulus.
Blood pressure monitoring in zoologically managed bonobos (Pan paniscus)
Authors: Danforth Marietta D. , Clyde Victoria L. , Jourdan Balbine , Korman Robert , Beehler Leann , Wann Samuel , Bapodra Priya , Murphy Hayley , Gerlach Trevor , Rich Sabina , Thorgerson Abigail M.
Published: February 2023

In response to the growing evidence that hypertension may play a significant role in the development of cardiovascular disease (CVD) in bonobos, the Great Ape Heart Project established a finger blood pressure (BP) monitoring protocol for zoo‐housed bonobos. The ability to monitor BP without the use of anesthesia provides more opportunities to detect potential hypertension in its early stages allowing for therapeutic intervention that may slow the progression of CVD. No BP reference ranges exist for bonobos due to the lack of an established protocol, the difficulty of measuring BP in animals, and small sample size of zoo‐housed bonobos. By working with all 8 institutions in North America that care for bonobos, it was possible to (1) investigate the feasibility of using finger BP devices, and (2) establish BP trends for male and female bonobos. Data were collected from May 2016 to March 2019. Zoos were asked to train for and collect BP measurements from any bonobos willing to participate, regardless of age, sex, or health status as well as to report on the quality of the training and measurements obtained. At the start of the study, the North American bonobo population consisted of 74 bonobos ages 5 years and older at 8 institutions. All 8 institutions submitted at total of 3656 BP readings from 50 bonobos (n = 23 females, n = 27 males; ages 5−51 years) representing 67.57% of the trainable population ages 5 years and older. Of the readings submitted, 2845 were determined to be good quality, reliable BP readings (77.81% useful BP measurements) for 36 of the 50 adult bonobos submitted for this study (59.01% of the adult population ages 10−51 years) but showed limitations in the protocol for the younger population. BP trend analysis showed significant differences between bonobos that were not on medication versus those treated with cardiac medications, with those on cardiac mediations having significantly higher systolic arterial pressure, diastolic arterial pressure, and mean arterial pressure (p ≤ 0.001 for all comparisons). Systolic BP generally increased over age classes (10−19, 20−29, 30−39, 40+ years).
Evaluating the impact of environmental education around Ranomafana National Park
Authors: Razafindravony Lovasoa E. , Donohue Mariah E. , Docherty Michael A. , Maggy Ashley M. , Lazasoa Rehodo S. , Rafanomezantsoa Onjaniaina J. S. , Ramarjaona Richard A. , Randriarimanana Jean N. M. , Rafanambinantsoa Andrianirina O. , Randrianarivelo Hajanirina , Wright Patricia C.
Published: February 2023

A total of 94% of lemur species are currently threatened with extinction and more than 17 species of giant lemur are already extinct. To help prevent the extinction of Madagascar's remaining lemurs, Dr. Patricia Wright initiated conservation programs in the Ranomafana region of southern Madagascar in the 1990s. These continued and expanded, and in 2003 were consolidated with Dr. Wright's research activities when Center ValBio (“CVB”) was founded in 2003. CVB believes in the “One Health” approach in understanding the relationship between humans and the environment, and one of their core principles is that effective conservation is science‐based. CVB's environmental education (EE) programs (discussed herein) operate in various primary schools surrounding Ranomafana national park (RNP). The all‐Malagasy team consists of long‐term conservation educators as well as young intern teachers, who together address the issues of valuing lemurs and the forests that they require to survive. In this paper, we will describe three of CVB's EE programs and evaluate their impact. The primary tool used to assess impact was an analysis of pre‐ and post ‐intervention test scores evaluated using a Kruskal–Wallis test. We show that these programs (1) are popular, (2) produce concrete outputs that can change rural villages, and (3) improve local knowledge on the importance of biodiversity and sustainable development.
The benefits and risks of non‐steroidal anti‐inflammatory drugs for postoperative analgesia in sinonasal surgery: a systematic review and meta‐analysis
Authors: Lee Daniel J. , Grose Elysia , Brenna Connor T. A. , Philteos Justine , Lightfoot David , Kirubalingam Keshinisuthan , Chan Yvonne , Palmer James N. , Adappa Nithin D. , Lee John M.
Published: February 2023

Background

Non‐steroidal anti‐inflammatory drugs (NSAIDs) have emerged as an alternative to opioids for optimal postoperative pain management. However, the adoption of NSAIDs in sinonasal surgery has been impeded by a theoretical concern for postoperative bleeding. Our objective is to systematically review the efficacy and safety of NSAIDs for patients undergoing sinonasal surgery.

Methods

MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials, CINAHL, and the WHO International Clinical Trials Registry Platform were searched from inception to January 27, 2022. Randomized controlled trials (RCTs) and comparative observational studies in any language were considered. Screening, data extraction, and risk of bias assessment were performed in duplicate. Our outcomes were postoperative pain scores, requirement for rescue analgesia, and postoperative adverse events (epistaxis, nausea/vomiting).

Results

Out of 4661 records, 15 RCTs (enrolling 1210 patients) and two observational studies were included. Following endoscopic sinus surgery, there was no difference in pain scores between NSAIDs and non‐NSAIDs groups (standardized mean differences [SMD] 0.44 units better, 95% CI –0.18 to 1.05). Following septorhinoplasty, NSAIDs decreased pain scores compared to non‐NSAID regimens (SMD 1.14 units better, 95% CI 0.61 to 1.67 units better). Overall, NSAIDs reduced the need for rescue medication with a relative risk (RR) of 0.45 (95% CI 0.24 to 0.84). In addition, NSAIDs decreased the risk of nausea with an RR of 0.62 (95% CI 0.42 to 0.91) and did not increase the risk of epistaxis (RR 0.72, 95% CI 0.23‐2.22).

Conclusion

Among patients undergoing sinonasal surgery, NSAIDs are beneficial in postoperative pain management and avoidance of postoperative nausea without increasing the risk of postoperative epistaxis.
The influences of low‐velocity impact loading on the vibration responses of the carbon/glass fiber‐reinforced epoxy composites interleaved with various non‐woven thermoplastic veils
Authors: Tarih Yavuz Selim , Coskun Taner , Yar Adem , Gundogdu Ömer , Sahin Ömer Sinan
Published: February 2023

Time‐dependent variable stresses that occur in composites subjected to mechanical and dynamic loads have devastating impacts on the material properties. Since these stresses reduce the service life, it is critical to detect and enhance structural responses before and after dynamic loadings. Therefore, the present study aimed to increase the toughness and delamination resistance of the conventional fiber‐reinforced composites by means of thermoplastic veil interleaves, thereby improving the vibration responses both before and after low‐velocity impact (LVI). In this context, carbon fiber (CF) and glass fiber (GF) reinforced epoxy composites interleaved with five different thermoplastic veils as Polyamide (PA), Polyetheretherketone (PEEK), Polyetherimide (PEI), Polyimide (PI) and Poly‐Phenylene Sulphide (PPS) were manufactured, and machined in accordance with the LVI standard. Composite specimens were subjected to the LVI tests, and then vibration tests were carried out for the non‐impacted and impacted specimens to determine dynamic properties. As a result, although thermoplastic veils generally have favorable effects on damping ratios of the GF composites, it has been revealed that these veils other than PPS and PI cause deterioration in CF composites. On the other hand, since vibration reduction depends on inherent damping and structural stiffness, this study also examined the storage‐to‐loss modulus ratios which denote the loss factors. In this respect, it was discovered that, while PPS, PEEK, PA, and PI thermoplastic veils included among the GF laminates ascend the loss factors of composites, only PI and PPS thermoplastic veils were shown to be positively effective in CF laminates. Moreover, CF and GF reinforced composites interleaved with thermoplastic veils generally exhibited higher natural frequency and lower damping ratio compared to the entirely CF or GF laminated composites. These results show that composite specimens gained bending stiffness due to local deformation hardening, and improved dynamic properties thanks to thermoplastic veil interleaved was attributed to increased toughness and delamination resistance.
NAMBER: A biotic index for assessing the ecological quality of mesophotic biogenic reefs in the northern Adriatic Sea
Authors: Piazzi Luigi , Turicchia Eva , Rindi Fabio , Falace Annalisa , Gennaro Paola , Abbiati Marco , Bandelj Vinko , Calcinai Barbara , Ciriaco Saul , Costantini Federica , Gianni Fabrizio , Kaleb Sara , Puce Stefania , Ponti Massimo
Published: February 2023

The aim of the present study was to propose a biotic index (North Adriatic Mesophotic BiogEnic Reefs, NAMBER) suitable for assessing the ecological quality of the mesophotic biogenic reefs of the northern Adriatic continental shelf based on photographic sampling.

At each of the 20 study sites, the degree of bioconstruction (expressed as percentage cover of crustose coralline algae), the α‐diversity (expressed as the mean number of taxa), and the degree of sensitivity to human disturbance and climate change (based on literature data and expert judgement) of the benthic assemblages were selected as descriptors and combined in the NAMBER index, using the best values that the three metrics can currently achieve in the studied region as a reference.

The study highlighted that there was large spatial heterogeneity among reefs and high variability in the ecological quality values obtained by NAMBER, ranging from bad to high. The index indicates that reefs lying furthest from the coast, under substantially lower anthropogenic pressure, have a generally higher status of environmental quality. However, a clear geographical pattern did not emerge, as reefs close together often had different ecological qualities.

The NAMBER index, which combines three ecological descriptors, in accordance with the requirements of the European Marine Strategy Framework Directive, represents a specific adaptation to the northern Adriatic Sea of a multimetric index previously developed for the north‐western Mediterranean Sea, capitalizing on previous knowledge and research efforts.

This multimetric biotic index provides an effective standardized tool for monitoring programmes and environmental impact assessments in the northern Adriatic mesophotic biogenic reefs and lays the foundation for ecosystem‐based management and conservation in this basin.
Archaeological prospection using WorldView‐3 short‐wave infrared (SWIR) satellite imagery: Case studies from the Fertile Crescent
Authors: Casana Jesse , Ferwerda Carolin
Published: February 2023

Geologists have long valued satellite imagery in the short‐wave infrared (SWIR) part of the electromagnetic spectrum (1100–2500 nm) because it can reveal subtle differences in minerology and soil moisture that are otherwise invisible, but the low spatial resolution (20‐30 m) of publicly available SWIR imagery has limited its utility for archaeological investigations. As part of a NASA‐funded research project, this paper presents results of an effort to evaluate the potential of higher resolution (3.7 m), 8‐band SWIR imagery from the WorldView‐3 satellite programme to aid in the identification and mapping of archaeological sites and landscape features in the Fertile Crescent. With case studies in the Amuq Plain of southern Turkey, the Khabur Plain of eastern Syria, and the Diyala Plain of southern Iraq, we utilize several methods including experiments with numerous band combinations, production of band ratios designed for crop cover analysis and support vector machine (SVM) classification techniques to enhance site visibility in multispectral SWIR imagery. Results reveal some of the seasonal, land use/cover and other factors that can impact the visibility of archaeological sites and features, demonstrating the potential and pitfalls of this emerging remote sensing resource.
Quantitative determination of plasma cabozantinib concentration using HPLC–UV and its application to patients with renal cell carcinoma
Authors: Maruyama Shinichi , Kato Masaru , Hiraga Tatsuru , Ishida Masaru , Kanno Hiroshi
Published: February 2023

Cabozantinib is an oral small‐molecule tyrosine kinase inhibitor that has become a standard of care for advanced renal cell carcinoma (RCC). However, cabozantinib is associated with a high rate of adverse events. Therefore, individualised cabozantinib administration and monitoring could help maximise its therapeutic efficacy and avoid serious adverse events. This study developed and validated a method to determine cabozantinib concentration in plasma using HPLC–UV. Sorafenib, an internal standard, was added to the plasma sample containing cabozantinib. A calibration curve for cabozantinib showed good linearity (R2 = 1.00), between 25 and 4,000 ng/ml. The recovery rate was above 92.1%, and the intra‐ and inter‐day coefficients of variation were smaller than 5.2 and 6.8%, respectively. Then, we applied the method for monitoring cabozantinib blood levels in three patients with advanced RCC who were taking cabozantinib at a dose of 20, 40 or 60 mg/day. Grade 3 adverse events were more likely to occur in patients with high dosing and blood level of cabozantinib. Owing to its simplicity, the developed method can be used in general hospitals, and is expected to help maximise drug efficacy and minimise serious adverse events in many patients with RCC undergoing cabozantinib treatment.
Essential innovation capability of producer‐service enterprises towards circular business model: Motivators and barriers
Authors: Shao Jing , Aneye Cedric , Kharitonova Alyona , Fang Wei
Published: February 2023

The current linear model inherent to the linear economy within the industry cannot continue its operations due to the high contribution towards environmental damage. To address this matter, the circular economy and the circular business models as environmental solutions for organizations will be capable of bringing business profit. Unfortunately, few studies have shed light on the types of capabilities and innovation required to produce the change to circular business models since these updates will lead to significant opportunities and challenges for enterprises. Thus, this research explores the factors that strengthen and hamper producer‐service enterprises' innovation capability to implement circular business model. The study applied the fuzzy Delphi method and grey‐based DEMATEL approaches to identify the most influential factors and the casual relationships among them towards circular business model implementation within the service sector. The research results indicated 10 main drivers and barriers related to circular business model implementation based on the fuzzy Delphi method. The contributions of this study can be used as a guide for producer‐service enterprises and other parties involved in policy‐making and shed light on the applications of business model innovations in general.
Luxury hotels' green practices and consumer brand identification: The roles of perceived green service innovation and perceived values
Authors: Dang‐Van Thac , Vo‐Thanh Tan , Wang Jianming , Nguyen Ninh
Published: February 2023

As a value‐added business strategy, many companies have planned and implemented green practices to promote their brands and contribute to sustainable development. This study aims to investigate how green practices build consumer brand identification for luxury hotel companies. Multivariate techniques and structural equation modeling were used to analyze a sample of 601 luxury hotel guests in China. The findings indicate that green hotel practices are positively related to consumer brand identification, and this relationship is positively mediated by perceived green service innovation, perceived utilitarian value, and perceived hedonic value. Furthermore, perceived utilitarian value and perceived hedonic value positively mediate the perceived green service innovation–consumer brand identification link. A robustness test with another sample data of 396 hotel guests was conducted, and this test confirmed the findings. This study provides several important implications for researchers and managers of the luxury hotel sector who aim to build customer brand identification from a green strategy perspective.
Polypyridyl CoII‐Curcumin Complexes as Photoactivated Anticancer and Antibacterial Agents
Authors: Yadav Ashish Kumar , Singh Virendra , Kushwaha Rajesh , Dolui Dependu , Rai Rohit , Dhar Prodyut , Dutta Arnab , Koch Biplob , Banerjee Samya
Published: February 2023

Four new CoIIcomplexes, [Co(bpy)2(acac)]Cl (1), [Co(phen)2(acac)]Cl (2), [Co(bpy)2(cur)]Cl (3), [Co(phen)2(cur)]Cl (4), where bpy=2,2’‐bipyridine (1and3), phen=1,10‐phenanthroline (2and4), acac=acetylacetonate (1and2), cur=curcumin monoanion (3and4) have been designed, synthesized and fully characterized. The X‐ray crystal structures of1and2indicated that the CoN4O2core has a distorted octahedral geometry. The photoactivity of these complexes was tuned by varying the π conjugation in the ligands. Curcumin complexes3and4had an intense absorption band near 435 nm, which made them useful as visible‐light photodynamic therapy agents; they also showed fluorescence withλem≈565 nm. This fluorescence was useful for studying their intracellular uptake and localization in MCF‐7 breast cancer cells. The acetylacetonate complexes (1and2) were used as control complexes to understand the role of curcumin. The white‐light‐triggered anticancer profiles of the cytosol targeting complexes3and4were investigated in detail. These non‐dark toxic complexes displayed significant apoptotic photo‐cytotoxicity (under visible light) against MCF‐7 cells through ROS generation. The control complexes1and2did not induce significant cell death in the light or dark. Interestingly,1‐4produced a remarkable antibacterial response upon light exposure. Overall, the reported results here can increase the boundary of the CoII‐based anticancer and antibacterial drug development.
Giant choledochal cyst: The largest reported!
Authors: Biswas Jyotirmoy , Nath Siddhartha , Ray Sukanta , Dhali Arkadeep , Karpha Kankana , Dhali Gopal Krishna
Published: February 2023

Choledochal cyst (CC) is an atypical congenital abnormality of the biliary system. CC more than 10 cm is rare and only a few cases are reported. Herein, we reported a 25 × 18 cm CC and highlighted how definitive treatment after a timely diagnosis provides good prognosis irrespective of the size.
Nonconvulsive status epilepticus as an unusual presentation of tuberculous meningoencephalitis: A case report
Authors: Tabatabaee Seyedehnarges , Almasi‐Dooghaee Mostafa , Gandomi‐Mohammadabadi Alireza , Tabatabaei Seyed‐Mohammad
Published: February 2023

We describe a 50‐year‐old woman who was recently diagnosed with tuberculosis, with acute alteration in mental status. EEG showed nonconvulsive status epilepticus features. Brain MRI revealed multiple ring‐enhancing lesions. She responded well to treatment for both status epilepticus and tuberculosis. Her level of consciousness improved and she became fully aware.
Lutembacher syndrome in a middle‐aged woman in Ghana with an extremely large atrial septal defect
Authors: Adu‐Boakye Yaw , Amponsah Gordon Manu , Andoh Henry Kofi , Gyan Kwadwo Faka , Wiafe Yaw Amo
Published: February 2023

Lutembacher syndrome (LS) is a rare heart disorder characterized by a congenital or acquired combination of the atrial septal defect (ASD) and mitral stenosis. In LS, patients may be asymptomatic for years, but early detection and treatment result in a better prognosis. In contrast, the prognosis is usually poor, with conservative treatment if the diagnosis is late and the patient develops heart failure and pulmonary hypertension. Although rheumatic heart disease (RHD) and congenital heart disease are prevalent in Ghana, cases of LS are not reported. Here, we report the case of a 45‐year‐old woman with rheumatic mitral valve stenosis and an exceptionally large ASD with bidirectional flow who was diagnosed with LS and treated conservatively for heart failure at a cardiology clinic in Ghana.
Inflammatory myofibroblastic tumor of the pericardium in an 11‐month‐old infant: A case report
Authors: Khalilian Mohammad Reza , Shamsian Bibi Shahin , Baghaei Tehrani Ramin , Kharaz Ladan , Talebian Niki
Published: February 2023

Primary cardiac tumors are very rare in infants. Here we present an 11‐month‐old infant with a pericardial inflammatory myofibroblastic tumor who presented with symptoms of respiratory distress and cardiac tamponade. The tumor was surgically removed, and the patient received medical treatment; the patient had no problem with follow‐up.
Aseptic ascites and chemical meningitis following ventriculoperitoneal shunting for craniopharyngioma: A first case report
Authors: Gader Ghassen , Badri Mohamed , Guediche Skander , Rkhami Mouna , Zammel Ihsèn
Published: February 2023

We report the case of a 4‐year‐old boy who had a ventriculoperitoneal shunt due to hydrocephalus related to a cystic craniopharyngioma. Postoperative, he presented abdominal distension and meningismus. Imaging showed regression of the tumor. The cyst was drained by the shunt. No similar situations were reported in the literature.
Fractionation of a Three‐Particle Mixture by Brownian Sieving Hydrodynamic Chromatography
Authors: Biagioni Valentina , Venditti Claudia , Adrover Alessandra , Cerbelli Stefano
Published: February 2023

Particles ranging in size from a few nanometers (exosomes or viruses) to a few micrometers (bacteria or red blood cells) can be sorted using a size‐based separation process. One of the simplest techniques is provided by hydrodynamic chromatography (HDC) which typically requires long channels to achieve adequate resolution. A new separation mechanism based on a Brownian sieving effect coupled with HDC has recently been proposed to overcome these limitations. An efficiency improvement of up to 2000 % has been predicted for a two‐size mixture. The aim of this work is to study and optimize a modified geometry useful for obtaining the simultaneous separation of a three‐size diluted suspension. The results suggest a significant performance improvement, up to 3000 %, over the standard HDC.
Hydrodynamic Behavior of Natural Adsorbents Filters for Water Treatment Technology
Authors: Alaoui Soufiane Bakri , Achak Mounia , Lamy Edvina
Published: February 2023

To quantify water flow occurring in filter beds employed during wastewater treatment, laboratory column tracer experiments were performed on natural low‐cost adsorbents (charcoal, oyster shell, and argan nutshell) under saturated flow conditions. The columns were packed with 100 % of adsorbents and with multi‐sand‐layer (MSL) system, consisting of permeable layers of pozzolan alternated with mixed layers (sand + adsorbent + sawdust). The results showed a more uniform flow in 100 % adsorbents for charcoal and oyster shell compared to their respective MSL columns. Conversely, flow uniformity was slightly improved in MSL versus 100 % adsorbent for argan nutshell columns. The choice of the appropriated adsorbent is crucial for the improvement of flow uniformity and treatment efficiency.
A pH‐Activatable Prodrug and Metal Prodrug Conjugate of Gossypol: Synthesis, Emergent Photophysical, Nanoscopic, Computational, and in‐Vitro Cellular Studies
Authors: Biswas Megha , Kajol  , Singha Dipankar , Rana Malay Kumar , Pathak Rakesh Kumar
Published: February 2023

The major hurdle to the success of many potent chemotherapeutic drugs is the lack of stability of their active form suited for a particular mode of action. Efforts are needed to stabilize such functionalities by employing new and novel strategies to overcome challenges. In this study, tumor‐environment‐specific, pH‐activatable prodrug and metal‐prodrug conjugate has been developed to ameliorate the side effects of chemotherapeutic drugs bearing reactive functionalities. As a proof of concept, a pre‐clinically tested natural compound, gossypol, was modified to form a pH‐responsive prodrug by incorporating an imine linkage amenable to form confined molecular structures through coordination with a bio‐relevant and nontoxic zinc metal ion. Detailed photophysical, computational, and nanoscopic studies revealed the unique zinc ion coordination behavior and its effect on molecular confinement. Computational studies demonstrated that an increasing degree of complexation, with Zn‐N−Py coordination, gradually turns off fluorescence by reducing the band gap that allows nonradiative decay. In‐vitro prodrug activation and release of gossypol from gossyzid and gossyzid‐Zn were assessed by ESI‐MS and RP‐HPLC studies. The gossyzid and gossyzid‐Zn demonstrated pH‐specific cytotoxicity validated by the number of in‐vitro cellular assays. Such a strategy can essentially be adapted to strengthen many chemotherapeutic drugs to enhance their efficacy and reduce side effects.
Solvato‐Controlled Assembly and Structural Transformation of Emissive Poly‐NHC‐Based Organometallic Cages and Their Applications in Amino Acid Sensing and Fluorescence Imaging
Authors: Zhang Heng , Li Yang , Zhang Yi‐Fan , Qiao Xiu‐Juan , Sun Li‐Ying , Li Jianli , Wang Yao‐Yu , Han Ying‐Feng
Published: February 2023

Stimuli‐induced structural transformation of supramolecular cages has drawn increasing attention because of their sensitive feature to external variations as model systems to simulate biological processes. However, combining structural transformation and useful functions has remained a difficult task. This study reports the solvato‐controlled self‐assembly of two unique topologies with different emission characteristics, a water‐soluble Ag8L4cage (A) and an Ag4L2cage (B), produced from the same sulfonate‐pendant tetraphenylethene (TPE) bridged tetrakis‐(1,2,4‐triazolium) ligand. Both cages show interesting solvent‐responsive reversible structural transformation, and the change of fluorescence signals can efficiently track the process. Additionally, water‐soluble cageAexhibits unique properties in thermochromism, thiol amino acid sensing, and subcellular imaging in aqueous media.
Factors related to human papillomavirus vaccine uptake and intentions among adults aged 18–26 and 27–45 years in the United States: A cross‐sectional study
Authors: Arevalo Mariana , Brownstein Naomi C. , Whiting Junmin , Vadaparampil Susan T. , Head Katharine J. , Meade Cathy D. , Islam Jessica Y. , Kasting Monica L. , Gwede Clement K. , Barrios‐Monroy Veronica , Christy Shannon M.
Published: February 2023

Background

The current study examined self‐reported human papillomavirus (HPV) vaccination uptake and intentions, and associations with psychosocial constructs among United States adults aged 18 to 26 and 27 to 45 years.

Methods

Data were collected via an online survey from participants recruited from a research panel. Outcomes were HPV vaccination uptake and intentions. Multivariable binary and ordered logistic regression models were used to examine associations between HPV vaccination outcomes and psychosocial constructs, sociodemographics, and previous health behaviors.

Results

HPV vaccination uptake in both age cohorts (N =  2722) was associated with multiple variables, including but not limited to: provider recommendation (adjusted odds ratio [aOR], 11.63 [95% CI, 7.70–17.56] and aOR, 14.26 [95% CI, 9.52–21.38], for those aged 18 to 26 and 27 to 45 years, respectively) and positive HPV vaccine attitudes (aOR, 2.40 [95% CI, 1.70–3.40] and aOR, 1.46 [95% CI,1.06–2.02]). Among those who did not report or were unsure of prior HPV vaccination (N =1894), only 4.6% and 8.1% (aged 18–26 and 27–45 years, respectively) reported being very likely to receive the HPV vaccine in the next year. Increased intentions were associated with more positive vaccine attitudes (aOR, 2.45 [95% CI, 1.91–3.15] and aOR, 2.19 [95% CI, 1.72–2.78]) and provider recommendation (yes vs no; aOR, 1.97 [95% CI, 1.38–2.83] and aOR, 1.82 [95% CI, 1.31–2.52]; don't know/can't remember vs no; aOR, 1.38 [95% CI, 1.03–1.84] and aOR, 1.60 [95% CI, 1.17–2.18]). Sociodemographics and health behaviors associated with increased intentions differed for each age cohort.

Conclusions

Individual and interpersonal factors were associated with HPV vaccination uptake and intentions. Findings reveal the need for targeted interventions to improve HPV vaccination rates among these age groups.