bluuebunny/crossref_metadata_2025 huggingface dataset:
Regulation of Biofilm Exopolysaccharide Biosynthesis and Degradation inPseudomonas aeruginosa
Authors: Ma Luyan Z. , Wang Di , Liu Yiwei , Zhang Zhenyu , Wozniak Daniel J.
Published: June 2022

Microbial communities enmeshed in a matrix of macromolecules, termed as biofilms, are the natural setting of bacteria. Exopolysaccharide is a critical matrix component of biofilms. Here, we focus on biofilm matrix exopolysaccharides in Pseudomonas aeruginosa. This opportunistic pathogen can adapt to a wide range of environments and can form biofilms or aggregates in a variety of surfaces or environments, such as the lungs of people with cystic fibrosis, catheters, wounds, and contact lenses. The ability to synthesize multiple exopolysaccharides is one of the advantages that facilitate bacterial survival in different environments. P. aeruginosa can produce several exopolysaccharides, including alginate, Psl, Pel, and lipopolysaccharide. In this review, we highlight the roles of each exopolysaccharide in P. aeruginosa biofilm development and how bacteria coordinate the biosynthesis of multiple exopolysaccharides and bacterial motility. In addition, we present advances in antibiofilm strategies targeting matrix exopolysaccharides, with a focus on glycoside hydrolases.
The Impact of RNA-DNA Hybrids on Genome Integrity in Bacteria
Authors: McLean Emma K. , Nye Taylor M. , Lowder Frances C. , Simmons Lyle A.
Published: June 2022

During the essential processes of DNA replication and transcription, RNA-DNA hybrid intermediates are formed that pose significant risks to genome integrity when left unresolved. To manage RNA-DNA hybrids, all cells rely on RNase H family enzymes that specifically cleave the RNA portion of the many different types of hybrids that form in vivo. Recent experimental advances have provided new insight into how RNA-DNA hybrids form and the consequences to genome integrity that ensue when persistent hybrids remain unresolved. Here we review the types of RNA-DNA hybrids, including R-loops, RNA primers, and ribonucleotide misincorporations, that form during DNA replication and transcription and discuss how each type of hybrid can contribute to genome instability in bacteria. Further, we discuss how bacterial RNase HI, HII, and HIII and bacterial FEN enzymes contribute to genome maintenance through the resolution of hybrids.
Review—Systematic Review on Electrochemical Biosensing of Breast Cancer miRNAs to Develop Alternative DCIS Diagnostic Tool
Authors: Sornambikai S. , Amir H. , Bhuvaneshwari G. , Ponpandian N. , Viswanathan C.
Published: June 2022

Till date, no systematic review is conducted on electrochemical biosensing of multiplexed breast cancer miRNAs to identify their suitability as an alternative diagnostic tool for ductal carcinoma in situ (DCIS). Original articles published in English from PUBMED, Science Direct, Scopus, MEDLINE, Cochrane Library, National Centre for Biotechnology Information, and Google scholar during Jan 2012–Feb 2022 were searched using set inclusion criteria. The Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) 2020 guidelines was followed to report this review. Methodological quality of the included studies was evaluated using Risk of Bias (ROB) assessment criteria. Out of 1973 screened articles, 17 studies were eligible and included in this review wherein, 1 study (5.88%) involving generic neutravidin modified nanolabel probe using biotintylated molecular beacons immobilized metal nanoparticles prepared using one pot assay to detect miRNAs 21 and 141 had low ROB and 16 studies (94.12%) had medium ROB. Medium ROB of majority of the included studies reveals its limited evidence to conclude its suitability for diagnosing DCIS using miRNAs. High quality studies with inter assays and validation are extensively needed for the development of diagnostic tool for DCIS via miRNAs.
Belumosudil, ROCK2-specific inhibitor, alleviates cardiac fibrosis by inhibiting cardiac fibroblasts activation
Authors: Liu Quan , Li Hua-Yang , Wang Shun-Jun , Huang Sui-Qing , Yue Yuan , Maihemuti Adilai , Zhang Yi , Huang Lin , Luo Li , Feng Kang-Ni , Wu Zhong-Kai
Published: June 2022

Although ρ-associated kinase-2 (ROCK2) is the main isoform of ρ-associated kinases (ROCKs) in the heart and more important in cardiac hypertrophy and fibrosis than ρ-associated kinase-1 (ROCK1), there has not been any pharmacological approach to inhibit ROCK2 selectively. Our study demonstrates for the first time that belumosudil, the first ROCK2-specific inhibitor, effectively ameliorates cardiac hypertrophy, fibrosis, and dysfunction induced by TAC via inhibiting cardiac fibroblasts activation.
Study on Simulation Test of Peat Soil Environment in Dianchi Lake
Authors: Cao Jing , Huang Siyang , Liu Wenlian , Kong Cheng , Gao Yue , Liu Fangyi
Published: June 2022

The effect and feasibility of peat soil environment (PSE) simulation pose a difficult problem for geotechnical environmental engineering. In this study, the actual content of humic group (HG) in peat soil of Dianchi Lake is determined, and the method of adding humic acid (HA) reagent into cohesive soil and soaking it in fulvic acid (FA) solution is used to simulate PSE of Dianchi Lake. By comparing the HG content of test samples and natural peat soil, the effect and feasibility of simulation test are studied. And the effects of HG on microstructure and material composition of PSE are analyzed by scanning electron microscopy (SEM) and X‐ray diffraction (XRD) tests. The test results show that the content of HG and its components of PSE in seven sites of Dianchi Lake are quite different. The simulation method used in this study can simulate the PSE with different HA and FA contents, but the simulation method of soaking samples in FA solution cannot reach the actual effect. The SEM test confirm that the pore size and pore connectivity will increase with the HA reagent. However, FA is wrapped on the skeleton of soil through adsorption and fills some pores, which reduces the pore diameter and weakens pore connectivity. The XRD test shows that both HA and FA can reduce the diffraction peak of main substances in the samples, but not including SiO2. The reason is that HG and cohesive soil particles undergo coordination exchange and ion exchange; free HG combines with cohesive soil particles and transforms into bound HG, forming an organic‐inorganic complex PSE.
Radiographic Investigation of Root Canal Morphology of Permanent Mandibular Molars in Makkah Population (Saudi Arabia) Using Cone-Beam Computed Tomography
Authors: Kenawi Laila Mohamed Mohamed , Althobaiti Raghad Fahad , Filimban Dina Mohammad , Alotaiby Sarra Dakheel Allah , Alharbi Majedh Awad , Kassar Wed Mohammed
Published: June 2022

Objectives. This study aimed to analyze the root canal morphology of first and second permanent mandibular molars among Makkah population by using cone-beam computed tomography (CBCT). Materials and Methods. CBCT images of two hundred eight patients were obtained from the Faculty of Dentistry, Umm Al-Qura University, Makkah, Saudi Arabia. In all images, mandibular first and second molars were evaluated for the number of roots and their morphology, number of root canals, canal configuration in each root according to Vertucci’s classification, and the presence of a C-shaped canal. Results. Most of the mandibular first molars had two roots (96.5%) and three root canals (77.7%). Type IV canal configuration prevailed (75.6%) in the mesial roots, and type I canal configuration prevailed (71.7%) in the distal roots. For the mandibular second molars, the majority had two roots (96.3%) and three root canals (82.7%). Type IV canal configuration prevailed (48%) in the mesial roots and type I (99.1%) in the distal roots. C-shaped canals were detected in 5.7% of the mandibular first molars and 4% of the mandibular second molars. There was no statistical difference between the mandibular first and second molars (

P
>
0.05

) in the shape of the roots and the presence of the C-shaped canals. Conclusion. Most of the mandibular molars in Makkah population presented with two roots and three root canals. The incidence of three-rooted mandibular molars was low, and it was higher in the first molars than second molars. The type IV root canal system prevailed in mesial roots and type I in distal roots.
Adult-Onset Still’s Disease with Dermatopathic Lymphadenitis Clinicopathologic Features: A Rare Case Report and Review of the Literature
Authors: Elhawary Reda A. , Nadeem Mir , Abdelwahed Mohammed S. , Somaily Mansour , Alemam Shahenda Y.
Published: June 2022

Adult-onset Still’s disease (AOSD) is an inflammatory disorder characterized by fever, arthritis, and a transient skin rash. It is a rare condition characterized by inflammatory multisystem changes of unknown cause. A 35-year-old woman was admitted to rheumatology department of tertiary care hospital complaining of painful wrist and skin rash as well as fever, generalized lymphadenopathy, weight loss, and fatigue. The early diagnosis of AOSD was confirmed by clinical history, examination, and laboratory tests, as well as a confirmatory skin biopsy with typical histopathological features, namely, upper epidermal dyskeratosis and dermal inflammatory neutrophilic infiltration. The patient’s condition was treated with steroids and NSAIDs, to which she responded well, and on follow-up, her symptoms regressed along with improvement in biochemical parameters. The authors suggest that skin biopsy and confirmation of histopathological diagnosis of AOSD are useful in the diagnosis and proper management of AOSD patients in cases with clinical suspicion of AOSD.
Integration and Application of Online Sports Resources Based on Multidimensional Intelligent Technology and Resource Optimization Architecture
Authors: Chu Ting
Published: June 2022

Share the relevant factors of the overall structure of the sports network in colleges and universities, and divide the overall structure of its operation system. In view of the unequal division of educational resources, this paper proposes the construction content of the college sports network education resource sharing mechanism: the construction of college sports network education resources, the college sports network education resource sharing platform, and the management and coordination of college network education resources sharing. In the guidance of cybernetics based on the basic characteristics of network education resources, the sharing of sports network education resources is realized, so as to effectively build a scientific evaluation index system.
Effectiveness of Proanthocyanidin plus Trimetazidine in the Treatment of Non-Small-Cell Lung Cancer with Radiation Heart Injury
Authors: Yin Hang , Zhao Yue , Sun Yucui , Liu Jia , Han Yingjun , Dai Zhentao
Published: June 2022

This study was intended to explore the effect of proanthocyanidin (PC) combined with trimetazidine in non-small-cell lung cancer (NSCLC) with radiation-induced heart damage (RIHD). It was a prospective randomized controlled study that 86 NSCLC patients with radiation treatment in Cangzhou People’s Hospital from January 2019 and June 2021 were enrolled and randomized to either the control group or the study group via the random table method, 43 cases in each group. The control group received trimetazidine, and the study group additionally received PC. The incidence of RIHD-related clinical manifestation, RIHD-related ECG, and RIHD-related cardiac ultrasound change were all lower in the study group. After radiotherapy, the serum level of superoxide dismutase (SOD) was higher, and malondialdehyde (MDA) was lower in the study group when compared with the control group. After radiotherapy, the serum levels of brain natriuretic peptide (BNP), cardiac troponin (cTnT), creatine kinase (CK), and creatine kinase isoenzymes (CKMB) were all lower in the study group when compared with the control group. The efficacy of PC plus trimetazidine for NSCLC with RIHD is superior to trimetazidine alone, and it significantly mitigates radiation-induced inflammatory response and oxidative stress.
Effects of Lysinibacillus sphaericus on Physicomechanical and Chemical Performance of OPC Blended with Natural Tuff and Pulverized Fly Ash
Authors: Mwangi Wanjiku Kelvin , Muthengia Jackson Wachira , Ogunah Joanne , Mutitu Daniel Karanja , Kinuthia John , Mwirichia Romano , Karanja Thiong’o Joseph , Mulwa Munyao Onesmus , Genson Muriithi , Waithaka Peter , Musyoki Munyao David
Published: June 2022

This paper reports study findings on the use of Lysinibacillus sphaericus (at 1.0 × 107 cells/ml concentration) to enhance and improve the physicomechanical and chemical properties of blended Ordinary Portland Cement (OPC). Blending was done separately with pulverized fly ash (PFA) and natural pozzolana (volcanic tuff) at substitution levels of 10%, 20%, 30%, 40%, 50%, 60%, and 70%. Mortar prisms of dimensions 40 mm by 40 mm by 160 mm were prepared and cured for the 2nd, 7th, 28th, 56th, and 90th days using Lysinibacillus sphaericus solution as mixing water and curing media. Commercial OPC and PPC mortar prisms cast and cured using distilled water were used as controls. Results showed that prisms treated with bacteria exhibited the highest performance on compressive strength development. Further microstructure analysis of blended cement incorporated with Lysinibacillus sphaericus bacteria showed significant amounts of reacted secondary cementitious materials compared to samples without bacteria. Bacteria presence was also found to reduce water demand during mixing and setting times and exhibited low porosity in relation to samples without bacteria. These results showed that the presence of alkaliphilic bacteria in the blended cement resulted in synergistic effect in enhancing the physicochemical and mechanical properties.
Acefylline Derivatives as a New Class of Anticancer Agents: Synthesis, Molecular Docking, and Anticancer, Hemolytic, and Thrombolytic Activities of Acefylline-Triazole Hybrids
Authors: Shahzadi Irum , Zahoor Ameer Fawad , Parveen Bushra , Rasul Azhar , Raza Zohaib , Ahmad Sajjad , Irfan Ali , El-Hiti Gamal A.
Published: June 2022

The synthesis of novel acefyllines and exploring their biological activities attract researchers due to their medicinal applications. Therefore, the current work reports the successful synthesis of a series of novel acefyllines in good yields, and their structures wereconfirmed using various spectroscopic methods. The synthesized acefyllines demonstrated moderate activity (cell viability = 22.55 ± 0.95% − 57.63 ± 3.65%) compared with the starting drug acefylline (cell viability = 80 ± 3.87%) against the human liver carcinoma (Hep G2 cell line). N-(4-Chlorophenyl)-2-(4-(3,4-dichlorophenyl)-5-((1,3-dimethyl-2,6-dioxo-2,3-dihydro-1H-purin-7(6H)-yl)methyl)-4H-1,2,4-triazol-3-ylthio)acetamide exhibited the most potent activity (cell viability = 22.55 ± 0.95%) among the synthesized derivatives. The in silico modeling studies were performed to predict the binding of the most potent derivative with a binding site that agreed with the results of the antiproliferative activity. The newly synthesized heterocycles exhibited the least hemolytic and moderate clot lysis activity.
Recent Review of Titania-Clay-Based Composites Emerging as Advanced Adsorbents and Photocatalysts for Degradation of Dyes over the Last Decade
Authors: Raza Asma , Rehman Rabia , Batool Madeeha
Published: June 2022

Textile industry being one of the most flourishing industries keeps growing and developing every year, and the consequences are not very pleasant. Even though its contribution towards economy of a country is indisputable, there are many pros and cons associated with it that should not be brushed aside, one of them being textile dye waste which is also growing at alarming rate. Many techniques have been designed to deal with this environmental crisis including adsorption and photodegradation of dye waste by various substances, both natural and synthetic. TiO2 and clay both have gained immense popularity in this area. Over the last decade, many successful attempts have been made to design TiO2-clay-based composites to combine and make the most of their individual capabilities to degrade textile dye waste. While clay is an effective adsorbent, inexpensive, innocuous, and a great ion exchanger, TiO2 provides supplementary active sites and free radicals and speeds up the degradation rate of dyes. This review summarizes various features of TiO2-clay-based composites including their surface characteristics, their role as dye adsorbents and photocatalysts, challenges in their implementation, and modifications to overcome these challenges made over the last decade.
Deformation, Bearing Capacity, and Reliability of Building Formwork System Based on Real-Time Monitoring
Authors: Ai Xinying , Wan Xuelin , Pan Zhaodong , Luo Zhenyuan , Yang Hui , Liu Liangkun , Jiang Ke
Published: June 2022

The deformation performance of aluminum alloy formwork under stress is investigated in this research using static tests. The entire model of aluminum alloy formwork under load during construction is investigated using finite element simulation. And then, there’s the project’s actual value. The function is established during the construction period under the limit state of typical use of the wall in terms of reliability. The fluctuation characteristics of the dependability index of the out-of-plane deformation of the concrete wall are explored, and various results are produced, by taking into account the various reinforcement variables of the aluminum formwork. The study discovered that when the number of uses increases during the turnover usage process, the bearing capacity of the building formwork support gradually decreases, and the associated reliability index falls below 2. Adding horizontal and vertical rods above 3.6 m to the single support system, in combination with other elements, is recommended to strengthen its stability. The results reveal that joint semirigidity and wall thickness have a significant influence on the ultimate bearing capacity of construction formwork. The change characteristics of building formwork ultimate bearing capacity in the process of repeated turnover use are studied by increasing the initial defect method to simulate the increase of building formwork turnover times, with the conclusion that the more repeated use times, the lower the building formwork ultimate bearing capacity.
Concrete Vehicle Scheduling Based on Immune Genetic Algorithm
Authors: Yang Jie , Yue Bin , Feng Feifei , Shi Jinfa , Zong Haoyang , Ma Junxu , Shangguan Linjian , Li Shuai
Published: June 2022

At present, the demand for ready-mixed concrete (RMC) in construction industry is increasing day by day, and the supply mode of multiple delivery depots corresponding to multiple construction sites has been widely used. In order to further improve the joint distribution efficiency between various delivery depots, this research establishes a multiobjective optimal distribution model with time window constraints and demand postponement attributes for the problem that the subbatching plants need to work together. The model divides the reasons for demand postponement into two types: the constraint for timely unloading of trucks cannot be met on time and the constraint for timely pouring at the construction site cannot be met on time. This work improved the coding method of genetic algorithm based on the characteristics of the distribution model. Using hierarchical real-coding form, the coding operator of each layer can be evolved separately, which ensures the globality of the search, and, at the same time, an improved immune operator is added to ensure the local search performance. By comparison, the results obtained by improved GA are 7.05% higher than those of the standard GA, and the early convergence speed of improved GA is obviously better than that of the standard GA. The simulation experiments show that the total trucks’ waiting time during the process of providing delivery services from 5 concrete plants to 8 construction sites is 769 minutes, and the total waiting time of 8 construction sites is 507 minutes. Through practical case analysis, this work can enable RMC production enterprises and construction sites to effectively reduce the waiting time of corresponding operations, and the obtained results are close to the simulation results. The proposed method indeed improves the efficiency of RMC distribution.
[Retracted] miR‐211‐5p Alleviates the Myocardial Ischemia Injury Induced by Ischemic Reperfusion Treatment via Targeting FBXW7
Authors: Liu Yonghui , Meng Jiatian , Di Hongqin , Zheng Liheng , Meng Zili
Published: June 2022

Cardiovascular diseases, a class of the most common diseases, seriously threaten human health, which is a direct inducement of death in most countries. The restoration of blood supply is an impactful intervention way for cardiovascular disease treatments while the injury induced by oxygen‐glucose deprivation and ischemic reperfusion (I/R) may further impact the tissues of the patients. Myocardial reperfusion is a precondition for saving ischemic myocardial tissues in acute myocardial infarction while the injury induced by immediate reperfusion takes a great challenge for cardiovascular disease treatment. Howbeit, the reperfusion of coronary blood could aggravate the injury triggered by ischemia. At present, several studies have focused on the etiopathogenesis and therapeutic strategies of ischemia‐reperfusion injury of the myocardium. The report has verified that miR‐211‐5p was elevated in the pathological specimens, while the influence of miR‐211‐5p in I/R‐mediated injury of myocardial cells remains unclear. This research is aimed at illustrating the role of miR‐211‐5p in the progression of I/R injury of myocardial cells, and qRT‐PCR, western blot, CCK‐8, and TUNEL assay were used to investigate the functions of miR‐211‐5p on I/R‐mediated injury of myocardial cells. The result mirrored that miR‐211‐5p was distinctly reduced in the I/R‐induced AC16, and reduced miR‐211‐5p could evidently improve the viability of I/R‐induced AC16. miR‐211‐5p could directly target FBXW7, and FBXW7 upregulation could reverse the improvement of AC16 in viability and apoptosis level after suffering I/R. Moreover, it was also proved that miR‐211‐5p can mediate the activation of Wnt/β‐catenin via attenuating FBXW7. Consequently, this investigation identified miR‐211‐5p as a positive role to attenuate the injury of myocardial cells when suffering I/R treatment.
Comparable Clinical Outcome Using Small or Large Gross Tumor Volume-to-Clinical Target Volume Margin Expansion in Neoadjuvant Chemoradiotherapy for Esophageal Squamous Cell Carcinoma
Authors: Lee Tae Hoon , Kim Hak Jae , Kim Byoung Hyuck , Kang Chang Hyun , Keam Bhumsuk , Moon Hyeon Jong , Seong Yong Won , Kim Suzy
Published: June 2022

The purpose of this study was to evaluate the feasibility of small primary gross tumor volume (GTV)-to-clinical target volume (CTV) margin expansion in neoadjuvant chemoradiation for esophageal squamous cell carcinoma. Medical records of 139 patients with locally advanced esophageal squamous cell carcinoma who underwent neoadjuvant chemoradiation and radical esophagectomy were retrospectively reviewed. Patients treated with longitudinal primary GTV-to-CTV margin expansion of 2 cm and no additional expansion of the CTV through the esophagus were classified into a small margin (SM) group (37 patients). The remaining 102 patients were classified as a large margin (LM) group. Patterns of recurrence including local and out-field regional recurrence rates were compared between the two groups. Clinical outcomes including rates of local control, regional control, failure-free survival, and overall survival were also compared. More patients in the SM group underwent paclitaxel + carboplatin, Mckeown esophagectomy, and intensity-modulated radiation therapy than in the LM group. With a median follow-up of 25.6 months, there was no significant difference in the crude rate of local recurrence (10.8% vs. 6.9%,

P
=
0.694

), out-field regional recurrence (27.0% vs. 19.6%,

P
=
0.480

), or out-field regional recurrence without in-field recurrence (10.8% vs. 12.7%,

P
=
0.988

) between the two groups. There was no significant difference in failure-free survival (5-year, 34.4% vs. 30.6%,

P
=
0.652

) or overall survival (44.1% vs. 38.5%,

P
=
1.000

), either. Esophageal fistula was not reported in the SM group (0.0% vs. 7.9%,

P
=
0.176

). In conclusion, a radiation field with 2 cm of longitudinal primary GTV-to-CTV was feasible in the neoadjuvant setting for esophageal squamous cell carcinoma treatment.
Development of a Risk Predictive Model for Evaluating Immune Infiltration Status in Invasive Thyroid Carcinoma
Authors: Pang Runming , Qin Chunxin
Published: June 2022

Aims. This study aimed to reveal the molecular characteristics and potential biomarker of immune-activated and immunosuppressive invasive thyroid carcinoma. Methods. Expression and clinical data for invasive thyroid carcinoma were obtained from the TCGA database. Tumor samples were divided into immune-activated or immunosuppressive groups based on the immune enrichment score calculated by ssGSEA. Differentially expressed genes (DEGs) between tumor vs. normal groups or between immune-activated vs. immunosuppressive groups were screened, followed by functional enrichment. Immune infiltration was evaluated using the ESTIMATE, CIBERSORTx, and EPIC algorithms, respectively. A random forest algorithm and Lasso cox analysis were used to identify gene signatures for risk model construction. Results. Totally 1171 DEGs were screened between tumor vs. normal groups, and multiple tumorigenesis-associated pathways were significantly activated in invasive thyroid carcinoma. Compared to immune-activated samples, immunosuppressive samples showed higher tumor purity, lower immune/stromal scores, and lower expression of immune markers, as well as lower infiltration abundance of CD4+ T cells and CD8+ T cells. A risk model based on a 12-immune signature (CCR7, CD1B, CD86, CSF2RB, HCK, HLA-DQA1, LTA, LTB, LYZ, NOD2, TNFRSF9, and TNFSF11) was developed to evaluate the immune infiltration status (AUC = 0.998; AUC of 0.958 and 0.979 in the two external validation datasets), which showed a higher clinical benefit and high accuracy. Immune-activated samples presented lower IC50 value for bortezomib, MG.132, staurosporine, and AZD8055, indicating sensitivity to these drugs. Conclusion. A 12-gene-based immune signature was developed to predict the immune infiltration status for invasive thyroid carcinoma patients and then to identify the subsets of invasive thyroid carcinoma patients who might benefit from immunotherapy.
Engineering Management Model Analysis Using Partial Differential Equation Hilbert Space
Authors: Han Chen
Published: June 2022

In the process of the rapid development of science and technology, people study many problems with the help of the independent variables, but the according descriptions have not been accurate enough. Therefore, many problems must be described by a function of more than one variable to more accurately get the results that people need to use the functions containing more than one variable and their partial derivatives to study the real problems of the method. Partial differential equations are closely and directly related to many problems in physics, mechanics, and engineering. It becomes an important bridge between mathematical theory and practical problems in physics, mechanics, and engineering. And the elements in Hilbert space, vectors, can represent vectors, functions, and phase quantities, while the special solutions of partial differential equations in solving physical problems can satisfy the common properties of Hilbert space. The analogy of functions and phase quantities to vectors can establish the function space and phase quantity space with geometric intuition. Based on Hilbert space theory, the key and difficult problems in engineering management can be explained by clear mathematical models by using the analogy method. The purpose of this study is to enrich the means of the building engineering management model, to broaden the horizon of managers, and to solve the problems in engineering management from a new dimension.
Research on Efficiency in Credit Risk Prediction Using Logistic-SBM Model
Authors: Li Dongmei , Li Liping
Published: June 2022

Network lending, an innovative financial lending product, is separated from traditional financial media and implemented on the Internet platform. We study the credit risk prediction of online loan based on risk efficiency analysis. Moreover, we put forward the concept of borrower risk efficiency and apply it to risk prediction. The main task of this study is to establish risk efficiency characteristics on the basis of referring to various risk characteristics and carry out risk prediction after passing the screening of a series of features. The framework is realized by combining logistic regression and slack-based measure (SBM), and feature selection and verification are carried out through machine learning and statistics. Firstly, the efficiency risk characteristics are extracted and the risk efficiency is calculated by MaxDEA. Secondly, the features are screened and verified by Python. Then, the efficiency value obtained by SBM method is used as a new index for the training and testing of logistic model together with the initial related indexes. Moreover, in order to prove the effectiveness of the proposed credit risk prediction control scheme based on risk efficiency, the research compares the prediction before and after adding the risk efficiency feature. The simulation results demonstrated that the logistic-SBM model is more suitable for credit risk prediction than the commonly used logistic method, which realized the efficient prediction of credit risk based on the logistic-SBM model. Finally, some suggestions are put forward to China’s regulatory authorities and the platform itself to control the credit risk of Internet lending industry.
Regulation of the Proliferation of Diabetic Vascular Endothelial Cells by Degrading Endothelial Cell Functional Genes with QKI‐7
Authors: Xu Jinmei , Zhao Qingsong , Han Xu , Zhang Zheqi , Qu Jiahui , Cheng Zhifeng
Published: June 2022

Background. Diabetes has emerged as one of the most serious and common chronic diseases of our times, causing life‐threatening, disabling and costly complications, and reducing life expectancy. Studies have shown that cardiovascular morbidity is 1–3 times higher in diabetic patients than in normal people. There are many clinical and experimental data that prove that most of the complications of diabetes are related to atherosclerosis, which suggests that chronic hyperglycemia may induce an imbalance in the proliferation of vascular endothelial cells. Purpose. This study aims to explore the relationship between QKI‐7 and vascular endothelial cell dysfunction and lay a foundation for further clarifying the molecular mechanism of endothelial cell damage in the process of diabetes with atherosclerosis. Methods. We chose blood samples and pluripotent stem cells and vascular endothelial cells of hospitalized patients with diabetes and diabetes atherosclerosis as research subjects. The expression levels of endothelial cell proliferation and genes related to endothelial cell proliferation were analyzed by RT‐qPCR and Western blot, to study the influence of QKi‐7 on the physiological state of endothelial cells. Through gene knockdown experiment, the effects of QKi‐7 knockdown on functional genes and physiological functions of endothelial cells were analyzed. Finally, RNA immunoprecipitation was used to test the mutual effect among QKI‐7 and the transcription level of functional genes, and the mRNA attenuation experiment proved that QKI‐7 participated in the degradation process of functional genes. Results. The findings of the RT‐qPCR and Western blot tests revealed that QKI‐7 was highly expressed in blood samples of diabetic patients and atherosclerosis as well as in endothelial cells induced by human pluripotent stem cells and human vascular endothelial cells after high‐glucose treatment. Overexpression and high glucose of QKI‐7 resulted in inhibiting expressed function genes CD144, NLGN1, and TSG6 and upregulation of inflammatory factors TNF‐α, IL‐1β, and IFN‐γ, leading to excessive proliferation of endothelial cells. After QKI‐7 gene knockdown, the expression levels of CD144, NLGN1, and TSG6, inflammatory factors TNF‐α, IL‐1β, and IFN‐γ, and the cell proliferation rate all returned to normal levels. RNA immunoprecipitation showed that QKi‐7 interacted with CD144, NLGN1, and TSG6 mRNAs and was involved in the transcriptional degradation of functional genes through their interactions. Conclusion. This research initially revealed the relevant molecular mechanism of QKI‐7 leading to the excessive proliferation of endothelial cells in diabetic and atherosclerotic patients. In view of the role of QKI‐7 in diabetic vascular complications, we provided a potential target for clinical diabetes treatment strategies in the future.
The Macroreform of the Electronics Manufacturing Industry under the Industry 4.0 Wave Based on Financial Performance Indicators
Authors: Wen Yixian
Published: June 2022

This study uses financial indicators dismantled by DuPont’s identity as evidence to invert the resource allocation of top companies in the electronics manufacturing industry and then delineates their strategic groups through factor analysis and cluster analysis. Also, the timeline is divided into two periods: from 2010 to 2013 and from 2014 to 2017. The impact of Industry 4.0 was determined by studying and comparing the strategic groups of top companies in these two periods. It is confirmed that the competitive environment in the electronics manufacturing industry did change in the period after the rollout of Industry 4.0, with the general trend being in capacity. In the late Industry 4.0 period, there was an increase in the number of top-performing companies in the group of companies whose competitive strategies were based on production management and supply chain management capabilities. Companies that invest more resources in fixed assets are able to use digitization, networking, and automation. Companies that achieve greater efficiency in their own factory’s production facilities can reap more benefits and widen the gap with their competitors.
A Blow-Up Criterion for 3D Nonhomogeneous Incompressible Magnetohydrodynamic Equations with Vacuum
Authors: Wang Shujuan , Tian Miaoqing , Su Rijian
Published: June 2022

For the strong solutions of the nonhomogeneous incompressible magnetohydrodynamics (MHD) system with vacuum, we establish a blow-up criterion for this system in terms ofuC0,T;L3ℝ3. Moreover, the result generalizes previous ones in Giga (1986) and He and Xin (2005) where homogeneous incompressible Navier-Stokes equations and homogeneous incompressible MHD system are considered, respectively, and demonstrates that the velocity field plays a more dominant role in the MHD system.
Green Innovation, Green Dynamic Capability, and Enterprise Performance: Evidence from Heavy Polluting Manufacturing Enterprises in China
Authors: Li Haiyan
Published: June 2022

Green innovation is widely regarded as a beneficial strategy for manufacturing enterprises to accelerate green transformation. Drawing the natural resource‐based view with dynamic capabilities, this study proposes a model linking green innovation, green dynamic capability, and firm performance. Using survey data from 236 heavy polluting manufacturing firms in China, this study investigates the impact of green innovation on firm performance. The results show that green innovation is positively correlated with both enterprise performance and green dynamic capability, whereas green dynamic capability also has a significant impact on enterprise performance. Furthermore, the survey found that the green resource integration ability, organizational learning capability, and environmental insight capability of green dynamic capability play a moderating effect on the relationship between green innovation and enterprise performance. Additionally, we provide useful enlightenment for policymakers and business managers to stimulate green innovation in enterprises. Our research not only assists managers to better grasp the effects of green innovation practices but also provides some important implications for policymakers.
Sustainability Improvement of Ethanol Blended Gasoline Fuelled Spark Ignition Engine by Nanoparticles
Authors: Thamilarasan J. , Ravikumar V. , Yadav S. Prasanna Raj , Yarlagadda Jyothi , Kumar Ashok , Ramasubramanian S. , Sambandam P. , Rudesh Challa Parvathi , Asres Yalew
Published: June 2022

The sophisticated technology being used in automotive technology, as well as the increased use of vehicles, enables the engine to operate on a variety of alternative fuels. Natural or synthetic carbon‐based connections are responsible for the formation of ethanol. They may be produced from a variety of sources, including agricultural feedstock, local crops, and even agricultural trash and waste products. Because they are in the form of a renewable resource, they may be employed in a variety of applications, including IC engines, where they can be used as fuel or as an addition, depending on their composition. It is possible to dramatically improve the performance of gasoline engines using a novel mix of nanoadditives, ethanol, and gasoline while simultaneously reducing the negative environmental impact. An ethanol‐gasoline combination was used to power the engine in this work, which examined the effects of the alumina nanoaddition. Results reveal that thermal efficiency can be improved by up to 17% while fuel consumption can be reduced by up to 16% on a volume basis, indicating a considerable improvement over the basic engine. Also validated was a decrease in dangerous carbon monoxide emissions of as much as 14%, a reduction in unburned hydrocarbon emissions of 18.5%, and a significant reduction in oxygen of as much as 18%.
Construction of Tourism Market Forecasting Model Based on Embedded Data Analysis System
Authors: Yu Huixia
Published: June 2022

With the harmonious development of China’s social environment and the substantial improvement of people’s living standards, tourism has shown its vigorous vitality. Tourism is a comprehensive industry in the tertiary sector and also a new industry that is valued by countries all over the world. Embedded systems are application-centric, based on modern computer technology, and can flexibly tailor software and hardware modules according to user needs. The purpose of this paper is to investigate whether the construction of a prediction model for the tourism market can be carried out using an embedded data analysis system to provide a basis for advance planning of the tourism market. The tourism market is the sum of the tourism demand market and the tourism supply market, reflecting the complex economic relations between countries, between countries and tourism operators, between tourism operators, and between tourism operators and tourists. This paper takes the tourism market as the research object focusing on a systematic analysis of the current state of market development and proposes the use of a variety of quantitative analysis methods to build a prediction model for the tourism market and to test and compare them. The experimental results of this paper show that the number of tourists will exceed 8.3 billion by 2025, and the tourism revenue will be close to 10 trillion yuan.
Ecolabel with Augmented Reality on the Website to Enhance Student Environmental Awareness
Authors: Safitri Desy , Lestari Ika , Maksum Arifin , Ibrahim Nurzengky , Marini Arita , Sudrajat Ajat , Zahari Musril , Iskandar Rossi
Published: June 2022

Industrial Revolution 4.0, accompanied by an environmental crisis, shows that modernization and technological sophistication do not make harmonization between nature and humans more closely intertwined. This harmony needs ecological consciousness nurtured from an early age which is a challenge for the Industrial Revolution 4.0. Using technology in this research aimed to examine enhancing student environmental awareness affected by ecolabel with web-based augmented reality at elementary schools in Setia Budi subdistrict in South Jakarta in Indonesia. Environmental awareness of the students was indicated by student environmental action related to solving the environmental problems, environmental manner of doing environmental activities, and noble values of sustainability to have conservation. This research population is elementary school students in Setia Budi subdistrict in South Jakarta in Indonesia with simple random sampling utilizing the Slovin Formula sampling technique. Data analysis procedure executed independent samples t-test. The decisions reveal that the average value for environmental awareness for the experimental class arrives at 56.406, significantly larger than that for the control group of 55.063 at a 0.05 significance level. The investigation found that ecolabel using augmented reality attached on the website can raise student environmental awareness.
Application of Fast P2P Traffic Recognition Technology Based on Decision Tree in the Detection of Network Traffic Data
Authors: Zheng Lin , Li Junjiao
Published: June 2022

With the rapid development of large-scale enterprise informatization construction, the network scale has become huge and complex, and the data traffic carried by the network is increasing. Accurate network traffic identification is the basis of network management and is of great significance to enterprise informatization construction and operation and maintenance. In response to the network operation and maintenance requirements of large enterprises, this paper analyzes the network architecture and network traffic distribution of large enterprise groups from the perspective of enterprise network operators and introduces the current operation and maintenance process of enterprise network performance failures. Maintenance process optimization and reengineering are carried out to plan and find out the shortcomings of the current process links and put forward corresponding solutions. Based on the research of traffic identification in recent years, a fast P2P network traffic anomaly identification algorithm based on decision tree model is proposed, which improves the efficiency and accuracy of network traffic application identification and network traffic anomaly data identification.
Cost‐Efficient Privacy‐Preserving Authentication and Key Management Scheme for Internet of Vehicle Ecosystem
Authors: Shah Tahir Ali , Algarni Fahad , Ullah Insaf , Abdullah Ako Muhammad , Noor Fazal , Asghar Khan Muhammad
Published: June 2022

Internet of vehicles (IoV) is an emerging area of advanced transportation systems, in which the functionality of traditional vehicular ad hoc networks (VANET) combined with the Internet of things (IoT). This technology allows vehicle users and drivers to interact in real time from anywhere and anytime. However, until recently, the major two problems that authentication and key management methods may solve are security and privacy. In this study, we offer a privacy‐preserving authentication and key management scheme for the IoV environment that is computationally and communication cost‐effective. We conducted a thorough security analysis, demonstrating that the proposed scheme is resistant to a variety of cryptographic attacks. We have included a cost analysis that indicates the proposed scheme is more efficient than IoV’s current privacy‐preserving authentication and key management schemes.
Long Noncoding RNA SCIRT Promotes HUVEC Angiogenesis via Stabilizing VEGFA mRNA Induced by Hypoxia
Authors: Gao Lianze , Yang Jihong , Li Yi , Liu Keyu , Sun Huilin , Tang Jing , Xia Zhengyuan , Zhang Liangqing , Hu Zhe
Published: June 2022

Ischemia-reperfusion injury (IRI) is closely associated the abnormal expression of long noncoding RNAs (lncRNAs), especially for their regulatory roles in IRI-related angiogenesis. This study applied a hypoxia-reoxygenation (HR) cell model to simulate the IRI condition, as well as RNA sequencing and RNA pull-down experiments to reveal roles of the lncRNA and Stem Cell Inhibitory RNA Transcript (SCIRT), in endothelial angiogenesis. We found that SCIRT was increased under the HR condition and exhibited a high expression correlation with angiogenesis marker VEGFA. RNA-seq data analysis further revealed that VEGFA-related angiogenesis was regulated by SCIRT in HUVECs. Gain and loss of function experiments proved that SCIRT posttranscriptionally regulated VEGFA via affecting its mRNA stability. Furthermore, HuR (ELAVL1), an RNA binding protein (RBP), was identified as a SCIRT-binding partner, which bound and stabilized VEGFA. Moreover, SCIRT promoted HuR expression posttranslationally by inhibiting its ubiquitination under the HR condition. These findings reveal that lncRNA SCIRT can mediate endothelial angiogenesis by stabilizing the VEGFA mRNA via modulating RBP HuR stability under the HR condition.
Effect of Chia Seed as Egg Replacer on Quality, Nutritional Value, and Sensory Acceptability of Sponge Cake
Authors: Aljobair Moneera Othman
Published: June 2022

This study aimed to make a cake by incorporating chia seed flour (CSF) at 0, 3, 5, and 7% with egg replacement at 0, 25, 50, and 100%, respectively. The addition of CSF increased the total proteins, fats, and mineral contents. However, cake volume, uniformity, and symmetry were lowered significantly (

p
>
0.05

) at an elevated level (5% and 7%) of CSF. Similarly, the cake depicted relatively higher textural hardness, springiness, cohesiveness, and chewiness upon addition of CSF. The higher substitution of CSF resulted in darker crust and crumb with lower sensory acceptability by the panelists, though the 3% CSF addition did not compromise the cake acceptance. Nonetheless, there were a significant rise in total phenolics and better antioxidant activity with CSF, measured as free radical scavenging activity. Most importantly, a massive rise in unsaturated fatty acids (ω-3, ω-6) and the simultaneous decline in total cholesterol were detected with increasing substitution of CSF.
Evaluation of the Clinical Characteristics of Patients with Food Protein-Induced Enterocolitis Syndrome: A Multicenter Study
Authors: Metbulut Azize Pınar , Özen Selime , Kendirci Nergiz , Usta Güç Belgin , Güvenir Hakan , Vezir Emine , Bahçeci Semiha , Can Demet , Kılıç Mehtap , Çapanoğlu Murat , Kılıç Mehmet , Karaatmaca Betül , Kocabaş Can Naci , Dibek Mısırlıoğlu Emine , Orhan Fazıl
Published: June 2022

Introduction: Food protein-induced enterocolitis syndrome (FPIES) is a rare non-IgE, cell-mediated food allergy disorder. We aimed to report the demographic characteristics, clinical features, and management of pediatric patients with FPIES. Methods: This retrospective study included all children diagnosed with FPIES at the pediatric allergy departments of the participating twelve study centers from January 2015 to November 2020. Results: A total of 73 patients (39 males, 53.4%) with a male/female ratio of 1.1 were included in the study. The median (interquartile ranges) age at symptom onset was 6 months (0.5–168, 4–9.5). The most frequent offending foods were cow’s milk, egg’s yolk, fish, and egg’s white, identified in 38.4% (n = 28), 32.9% (n = 24), 21.9% (n = 16) and 20.5% (n = 15) of the patients, respectively. The total number of reported FPIES episodes was 290 (3.9 episodes per child). Oral food challenge (OFC) was performed in 54.8% (n = 40) of the patients, and tolerance was detected in 17 OFCs (42.5%) at a median age of 15 months (range 8–132 months). Conclusion: FPIES is a non-IgE-mediated food hypersensitivity that commonly affects infants and is often misdiagnosed. The pathophysiology of the disease remains unclear and the low awareness of FPIES among physicians and parents highlights the need for more education.