bluuebunny/crossref_metadata_2025 huggingface dataset:
Stress analysis and applicability analysis of the elliptical head
Authors: Wang Zhanhui , Zhang Zhifang , Chen Jinzhong , Bai Jinjun
Published: November 2021

As the main pressure components of pressure vessels, the mechanical performance of cylinders and heads affects the normal operation of pressure vessels. At present, no unified theoretical formula exists for the connection region between an elliptical head and the cylinder. Therefore, the authors consider the standard elliptical head as the research object. First, the theoretical stress calculation formula is deduced according to the deformation continuity equation. Second, the stress is experimentally measured using an internal-pressure thin-walled-vessel stress measurement device, and the theoretical and experimental stress values in the discontinuous region between the elliptical head and cylinder are analysed and compared to verify the accuracy and applicability of the theoretical stress calculation formula. The results show that the theoretical stress calculation formula in the discontinuous region between the elliptical head and cylinder is valid. By comparing and analysing the theoretical and experimental stress values, the accuracy and applicability of the theoretical stress calculation formula in the discontinuous region are verified. The findings can provide guidance for the stress measurement of internal-pressure vessels.
Investigating the Campylobacter enteritis winter peak in Germany, 2018/2019
Authors: Rosner Bettina M. , Gassowski Martyna , Albrecht Stefan , Stark Klaus
Published: November 2021

Surveillance of notified Campylobacter enteritis in Germany revealed a recurrent annual increase of cases with disease onset several days after the Christmas and New Year holidays (“winter peak”). We suspected that handling and consumption of chicken meat during fondue and raclette grill meals on the holidays were associated with winter peak Campylobacter infections. The hypothesis was investigated in a case–control study with a case-case design where notified Campylobacter enteritis cases served as case-patients as well as control-patients, depending on their date of disease onset (case-patients: 25/12/2018 to 08/01/2019; control-patients: any other date between 30/11/2018 and 28/02/2019). The study was conducted as an online survey from 21/01/2019 to 18/03/2019. Adjusted odds ratios (aOR) were determined in single-variable logistic regression analyses adjusted for age group and sex. We analysed 182 data sets from case-patients and 260 from control-patients and found associations of Campylobacter infections after the holidays with meat fondue (aOR 2.2; 95% confidence interval (CI) 1.2–3.8) and raclette grill meals with meat (aOR 1.5; 95% CI 1.0–2.4) consumed on the holidays. The associations were stronger when chicken meat was served at these meals (fondue with chicken meat: aOR 2.7; 95% CI 1.4–5.5; raclette grill meal with chicken meat: aOR 2.3; 95% CI 1.3–4.1). The results confirmed our initial hypothesis. To prevent Campylobacter winter peak cases in the future, consumers should be made more aware of the risks of a Campylobacter infection when handling raw meat, in particular chicken, during fondue or raclette grill meals on the holidays.
RNA assay identifies a previous misclassification of BARD1 c.1977A>G variant
Authors: Rofes Paula , Pineda Marta , Feliubadaló Lídia , Menéndez Mireia , de Cid Rafael , Gómez Carolina , Montes Eva , Capellá Gabriel , Brunet Joan , del Valle Jesús , Lázaro Conxi
Published: November 2021

Case–control studies have shown an association of BARD1 with hereditary breast and/or ovarian cancer (HBOC) predisposition. BARD1 alternatively spliced isoforms are abundant and some are highly expressed in different cancer types. In addition, a number of BARD1 germline pathogenic variants have been reported among HBOC patients. In previous reports, BARD1 c.1977A>G variant has been classified as pathogenic since it produces a frameshift transcript lacking exons 2 to 9. In the present study, we sought to validate the mRNA splicing results previously published and to contribute with new evidence to refine the classification of this substitution according to ACMG/AMP guidelines. The presence of the variant was screened in patients and controls. RT-PCR was performed in order to compare the transcriptional profiles of two variant carriers and ten non-carrier controls. In addition, allele-specific expression was assessed. No differences in variant frequency were detected between patients and controls. The RNA assay confirmed the presence of the shorter transcript lacking exons 2–9, but it was detected both in carriers and non-carriers. Furthermore, allelic imbalance was discarded and no significant differences in the proportion of full-length and shorter transcript were detected between carriers and controls. The shorter transcript detected corresponds to BARD1 isoform η, constituted by exons 1, 10 and 11. Our results support that this transcript is a constitutive splicing product rather than an aberrant transcript caused by BARD1 c.1977A>G variant, and for this reason this variant should be considered as likely benign following ACMG/AMP guidelines.
A wireless radiofrequency-powered insect-scale flapping-wing aerial vehicle
Authors: Ozaki Takashi , Ohta Norikazu , Jimbo Tomohiko , Hamaguchi Kanae
Published: November 2021

Insect-scale aerial vehicles are useful tools for communication, environmental sensing and surveying confined spaces. However, the lack of lightweight high-power-density batteries has limited the untethered flight durations of these micro aerial vehicles. Wireless power transmission using radiofrequency electromagnetic waves could potentially offer transmissivity through obstacles, wave-targeting/focusing capabilities and non-mechanical steering of the vehicles via phased-array antennas. But the use of radiofrequency power transmission has so far been limited to larger vehicles. Here we show that a wireless radiofrequency power supply can be used to drive an insect-scale flapping-wing aerial vehicle. We use a sub-gram radiofrequency power receiver with a power-to-weight density of 4,900 W kg–1, which is five times higher than that of off-the-shelf lithium polymer batteries of similar mass. With this system, we demonstrate the untethered take off of the flapping-wing micro aerial vehicle. Our RF-powered aircraft has a mass of 1.8 g and is more than 25 times lighter than previous radiofrequency-powered micro aerial vehicles.
Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer
Authors: Joshi Suhasini , Gomes Erica DaGama , Wang Tai , Corben Adriana , Taldone Tony , Gandu Srinivasa , Xu Chao , Sharma Sahil , Buddaseth Salma , Yan Pengrong , Chan Lon Yin L. , Gokce Askan , Rajasekhar Vinagolu K. , Shrestha Lisa , Panchal Palak , Almodovar Justina , Digwal Chander S. , Rodina Anna , Merugu Swathi , Pillarsetty NagaVaraKishore , Miclea Vlad , Peter Radu I. , Wang Wanyan , Ginsberg Stephen D. , Tang Laura , Mattar Marissa , de Stanchina Elisa , Yu Kenneth H. , Lowery Maeve , Grbovic-Huezo Olivera , O’Reilly Eileen M. , Janjigian Yelena , Healey John H. , Jarnagin William R. , Allen Peter J. , Sander Chris , Erdjument-Bromage Hediye , Neubert Thomas A. , Leach Steven D. , Chiosis Gabriela
Published: November 2021

Cancer cell plasticity due to the dynamic architecture of interactome networks provides a vexing outlet for therapy evasion. Here, through chemical biology approaches for systems level exploration of protein connectivity changes applied to pancreatic cancer cell lines, patient biospecimens, and cell- and patient-derived xenografts in mice, we demonstrate interactomes can be re-engineered for vulnerability. By manipulating epichaperomes pharmacologically, we control and anticipate how thousands of proteins interact in real-time within tumours. Further, we can essentially force tumours into interactome hyperconnectivity and maximal protein-protein interaction capacity, a state whereby no rebound pathways can be deployed and where alternative signalling is supressed. This approach therefore primes interactomes to enhance vulnerability and improve treatment efficacy, enabling therapeutics with traditionally poor performance to become highly efficacious. These findings provide proof-of-principle for a paradigm to overcome drug resistance through pharmacologic manipulation of proteome-wide protein-protein interaction networks.
Reversion of antibiotic resistance in multidrug-resistant pathogens using non-antibiotic pharmaceutical benzydamine
Authors: Liu Yuan , Tong Ziwen , Shi Jingru , Jia Yuqian , Deng Tian , Wang Zhiqiang
Published: November 2021

Antimicrobial resistance has been a growing concern that gradually undermines our tradition treatment regimens. The fact that few antibacterial drugs with new scaffolds or targets have been approved in the past two decades aggravates this crisis. Repurposing drugs as potent antibiotic adjuvants offers a cost-effective strategy to mitigate the development of resistance and tackle the increasing infections by multidrug-resistant (MDR) bacteria. Herein, we found that benzydamine, a widely used non‐steroidal anti‐inflammatory drug in clinic, remarkably potentiated broad-spectrum antibiotic-tetracyclines activity against a panel of clinically important pathogens, including MRSA, VRE, MCRPEC and tet(X)-positive Gram-negative bacteria. Mechanistic studies showed that benzydamine dissipated membrane potential (▵Ψ) in both Gram-positive and Gram-negative bacteria, which in turn upregulated the transmembrane proton gradient (▵pH) and promoted the uptake of tetracyclines. Additionally, benzydamine exacerbated the oxidative stress by triggering the production of ROS and suppressing GAD system-mediated oxidative defensive. This mode of action explains the great bactericidal activity of the doxycycline-benzydamine combination against different metabolic states of bacteria involve persister cells. As a proof-of-concept, the in vivo efficacy of this drug combination was evidenced in multiple animal infection models. These findings indicate that benzydamine is a potential tetracyclines adjuvant to address life-threatening infections by MDR bacteria.
The conserved single-cleavage mechanism of animal DROSHA enzymes
Authors: Nguyen Thuy Linh , Nguyen Trung Duc , Nguyen Tuan Anh
Published: November 2021

RNase III enzymes typically cleave both strands of double-stranded RNAs (dsRNAs). We recently discovered that a human RNase III, DROSHA, exhibits a single cleavage on the one strand of primary microRNAs (pri-miRNAs). This study revealed that DROSHAs from the other animals, including worms and flies, also show the single cleavage on dsRNAs. Furthermore, we demonstrated that the mechanism of single cleavage is conserved in animal DROSHA enzymes. In addition, the dsRNA-binding domain (dsRBD) and a 3p-strand cleavage-supporting helix (3pCSH) of the DROSHA enzymes foster a weak single cleavage on one strand, which ensures their double cleavages. Disrupting the interaction of dsRBD-RNA and 3pCSH-RNA by an internal loop (IL) and a 3pCSH-loop in the lower stem of pri-miRNAs, respectively, inhibits one of the double cleavages of DROSHAs, and this results in the single cleavage. Our findings expand our understanding of the enzymatic mechanisms of animal DROSHAs. They also indicate that there are currently unknown cellular functions of DROSHA enzymes using their single cleavage activity.
Phosphorothioate-DNA bacterial diet reduces the ROS levels in C. elegans while improving locomotion and longevity
Authors: Huang Qiang , Li Ruohan , Yi Tao , Cong Fengsong , Wang Dayong , Deng Zixin , Zhao Yi-Lei
Published: November 2021

DNA phosphorothioation (PT) is widely distributed in the human gut microbiome. In this work, PT-diet effect on nematodes was studied with PT-bioengineering bacteria. We found that the ROS level decreased by about 20–50% and the age-related lipofuscin accumulation was reduced by 15–25%. Moreover, the PT-feeding worms were more active at all life periods, and more resistant to acute stressors. Intriguingly, their lifespans were prolonged by ~21.7%. Comparative RNA-seq analysis indicated that many gene expressions were dramatically regulated by PT-diet, such as cysteine-rich protein (scl-11/12/13), sulfur-related enzyme (cpr-2), longevity gene (jnk-1) and stress response (sod-3/5, gps-5/6, gst-18/20, hsp-12.6). Both the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis suggested that neuroactivity pathways were upregulated, while phosphoryl transfer and DNA-repair pathways were down-regulated in good-appetite young worms. The findings pave the way for pro-longevity of multicellular organisms by PT-bacterial interference.
A Bayesian framework for deriving sector-based methane emissions from top-down fluxes
Authors: Cusworth Daniel H. , Bloom A. Anthony , Ma Shuang , Miller Charles E. , Bowman Kevin , Yin Yi , Maasakkers Joannes D. , Zhang Yuzhong , Scarpelli Tia R. , Qu Zhen , Jacob Daniel J. , Worden John R.
Published: November 2021

Atmospheric methane observations are used to test methane emission inventories as the sum of emissions should correspond to observed methane concentrations. Typically, concentrations are inversely projected to a net flux through an atmospheric chemistry-transport model. Current methods to partition net fluxes to underlying sector-based emissions often scale fluxes based on the relative weight of sectors in a prior inventory. However, this approach imposes correlation between emission sectors which may not exist. Here we present a Bayesian optimal estimation method that projects inverse methane fluxes directly to emission sectors while accounting uncertainty structure and spatial resolution of prior fluxes and emissions. We apply this method to satellite-derived fluxes over the U.S. and at higher resolution over the Permian Basin to demonstrate that we can characterize a sector-based emission budget. This approach provides more robust comparisons between different top-down estimates, critical for assessing the efficacy of policies intended to reduce emissions.
Increased microbial expression of organic nitrogen cycling genes in long-term warmed grassland soils
Authors: Séneca Joana , Söllinger Andrea , Herbold Craig W , Pjevac Petra , Prommer Judith , Verbruggen Erik , Sigurdsson Bjarni D , Peñuelas Josep , Janssens Ivan A , Urich Tim , Tveit Alexander T , Richter Andreas
Published: November 2021

Global warming increases soil temperatures and promotes faster growth and turnover of soil microbial communities. As microbial cell walls contain a high proportion of organic nitrogen, a higher turnover rate of microbes should also be reflected in an accelerated organic nitrogen cycling in soil. We used a metatranscriptomics and metagenomics approach to demonstrate that the relative transcription level of genes encoding enzymes involved in the extracellular depolymerization of high-molecular-weight organic nitrogen was higher in medium-term (8 years) and long-term (>50 years) warmed soils than in ambient soils. This was mainly driven by increased levels of transcripts coding for enzymes involved in the degradation of microbial cell walls and proteins. Additionally, higher transcription levels for chitin, nucleic acid, and peptidoglycan degrading enzymes were found in long-term warmed soils. We conclude that an acceleration in microbial turnover under warming is coupled to higher investments in N acquisition enzymes, particularly those involved in the breakdown and recycling of microbial residues, in comparison with ambient conditions.
An electrochemical sensor based on a Co3O4–ERGO nanocomposite modified screen-printed electrode for detection of uric acid in artificial saliva
Authors: Turkkan Gizem , Bas Salih Zeki , Atacan Keziban , Ozmen Mustafa
Published: November 2021

The schematic illustration shows the Co3O4–ERGO/SPE sensor and electro-oxidation mechanism of uric acid. The present sensor allows for quick and simple detection of UA in a few drops of a saliva sample as well as point-of-care testing.
O-Acetylated sugars in the gas phase: stability, migration, positional isomers and conformation
Authors: Yeni Oznur , Gharbi Amira , Chambert Stéphane , Rouillon Jean , Allouche Abdul-Rahman , Schindler Baptiste , Compagnon Isabelle
Published: November 2021

Is the position of the acetyl group modified through the transfer from solution to the gas phase?
Nano-goethite-mediated transformation of anthracene derivatives under low moisture conditions
Authors: Cheng Pengfei , Zhang Wei , Zhao Xuqiang , Yang Bing , Gao Yanzheng
Published: November 2021

Nano-goethite exhibited a superior activity in the transformation of ANT and ANT derivatives under low moisture conditions.
Increase in germline methyltransferases governing the methylation of histone H3K9 is associated with transgenerational nanoplastic toxicity in Caenorhabditis elegans
Authors: Zhang Le , Wang Shuting , Zhao Yue , Bi Kun , Wang Dayong
Published: November 2021

Our data demonstrated the association of the increase in germline methyltransferases required for methylation of H3K9 with transgenerational nanoplastic toxicity in nematodes.
Manipulation of cancer cells in a sessile dropletviatravelling surface acoustic waves
Authors: Nam Hyeono , Sung Hyung Jin , Park Jinsoo , Jeon Jessie S.
Published: November 2021

TSAWs quickly form a tumor spheroid for a drug screening platform.
Theoretical investigations in the reactions of group 15 analogues of the monocationic five-membered N-heterocyclic carbenes: interplay of electrophilicity, basicity, and aromaticity governing the reactivity
Authors: Zhang Zheng-Feng , Su Ming-Der
Published: November 2021

The nature of the group 15 analogs of the five-membered N-heterocyclic carbenes (G15-Rea; G15 = N, P, As, Sb, and Bi) was investigated by using various methodologies.
Surface-confined formation of conjugated porphyrin-based nanostructures on Ag(111)
Authors: Cao Nan , Riss Alexander , Corral-Rascon Eduardo , Meindl Alina , Auwärter Willi , Senge Mathias O. , Ebrahimi Maryam , Barth Johannes V.
Published: November 2021

On the Ag(111) surface and mediated by temperature, McMurry coupling resulted in the construction of conjugated porphyrin nanostructures linked by CC, which were identified by high resolution STM and nc-AFM images and XPS.
Pyroelectric effect mediated infrared photoresponse in Bi2Te3/Pb(Mg1/3Nb2/3)O3–PbTiO3 optothermal ferroelectric field-effect transistors
Authors: Zheng R. , Yan M. Y. , Li C. , Yin S. Q. , Chen W. D. , Gao G. Y. , Yan J. M. , Chai Y.
Published: November 2021

A modulation of the resistance of Bi2Te3 films via the pyroelectric effect in Bi2Te3/Pb(Mg1/3Nb2/3)O3–PbTiO3 optothermal ferroelectric field-effect transistors.
Correction: Rashba exciton in a 2D perovskite quantum dot
Authors: Swift Michael W. , Lyons John L. , Efros Alexander L. , Sercel Peter C.
Published: November 2021

Correction for ‘Rashba exciton in a 2D perovskite quantum dot’ by Michael W. Swift et al., Nanoscale, 2021, 13, 16769–16780, DOI: 10.1039/D1NR04884H.
Stimuli-responsive destructible polymeric hydrogels based on irreversible covalent bond dissociation
Authors: Shahi Sina , Roghani-Mamaqani Hossein , Talebi Saeid , Mardani Hanieh
Published: November 2021

Covalently crosslinked stimuli-destructible hydrogels with the ability of irreversible bond dissociation have attracted great attentions due to their biodegradability, stability against hydrolysis, and controlled solubility upon insertion of desired triggers.
Elucidating the selectivity of dyotropic rearrangements of β-lactones: a computational survey
Authors: Zhang Jingyang , Ma Yumiao , Qiu Ke , Li Bo , Xue Zhengwen , Tian Boxue , Tang Yefeng
Published: November 2021

A comprehensive computational study on dyotropic rearrangements of β-lactones has been performed for the first time, which provides a valuable guidance for predicting and controlling the selectivity of the reactions.
Electrophilic N-trifluoromethylthiophthalimide as a fluorinated reagent in the synthesis of acyl fluorides
Authors: Zhu Chen , Zhumagazy Serik , Yue Huifeng , Rueping Magnus
Published: November 2021

Herein we report the deoxygenated fluorination of readily available carboxylic acids. A series of acyl fluorides have been synthesized using shelf-stable N-trifluoromethylthiophthalimide as a fluorinated reagent for the first time.
Production of liquid fuels from Kraft lignin over bimetallic Ni–Mo supported on ZIF-derived porous carbon catalyst
Authors: Guo Ge , Li Wenzhi , Ahmed Tauseef , Hu DuoDuo , Cui Ru , Zhang Baikai , Zhang Xia
Published: November 2021

The structure and synergy of NiMo@FDC catalyst have a significant effect on realizing the production of lignin-derived liquid fuels from Kraft lignin.
Disulfur-bridged polyethyleneglycol/DOX nanoparticles for the encapsulation of photosensitive drugs: a case of computational simulations on the redox-responsive chemo-photodynamic drug delivery system
Authors: Ma Zhenchao , Wu Juanping , Sun Mengchi , Li Bingyu , Yu Xiang
Published: November 2021

Schematic of disulfide/dicarbide-bridged DOX polymer-encapsulated photosensitive drugs Ce6: a case of computational simulations on the redox-responsive chemo-photodynamic drug delivery system.
Effect of interfacial defects on the electronic properties of MoS2 based lateral T–H heterophase junctions
Authors: Bahmani Mohammad , Ghorbani-Asl Mahdi , Frauenheim Thomas
Published: November 2021

Our systematic study shows significant improvement in transport properties of MoS2-based lateral T–H heterophase junctions when interfacial defects are present.
Effect of a modified 13X zeolite support in Pd-based catalysts for hydrogen oxidation at room temperature
Authors: Jang Younghee , Lee Sang Moon , Kim Sung Su
Published: November 2021

This study investigated the effect of a modified 13X zeolite to Pd/zeolite catalyst on the oxidation of hydrogen to ensure safety from hydrogen leakage.
Solution-phase synthesis of oligodeoxyribonucleotides using the H-phosphonate method with N-unprotected 5′-phosphite monomers
Authors: Matsuda Hiromasa , Yoshida Erina , Shinoda Takaaki , Sato Kazuki , Hara Rintaro Iwata , Wada Takeshi
Published: November 2021

A new strategy for a solution-phase synthesis of oligodeoxyribonucleotides with 5′-phosphite monomers synthesized in a single step from unprotected 2′-deoxyribonucleosides.
Enhancing the activation of persulfate using nitrogen-doped carbon materials in the electric field for the effective removal of p-nitrophenol
Authors: Tang Mengdi , Zhang Yonggang
Published: November 2021

In the process of electro-activation of PDS by carbon cathode, PNP was removed from water mainly through SO4˙− produced by cathode, ˙OH and 1O2 produced indirectly, direct electron transfer and non-free radical oxidation of anode.
Composite photocatalysts based on Cd1−xZnxS and TiO2 for hydrogen production under visible light: effect of platinum co-catalyst location
Authors: Zhurenok Angelina V. , Markovskaya Dina V. , Gerasimov Evgeny Yu. , Cherepanova Svetlana V. , Bukhtiyarov Andrey V. , Kozlova Ekaterina A.
Published: November 2021

The determination of the preferred location of platinum particles in TiO2–Cd1−xZnxS systems was carried out for the first time.
Synthesis of asymmetric [bis(imidazolyl)-BH2]+-cation-based ionic liquids as potential rocket fuels
Authors: Li Xue , Zhang Yin , Li Hongping , Ding Jing , Wan Hui , Guan Guofeng
Published: November 2021

Asymmetric [bis(imidazolyl)-BH2]+-cation-based hypergolic ionic liquids are successfully synthesized, which possess a high density-specific impulse ranging from 305.4 to 357.8 s g cm−3, that make them promising candidates for rocket propellants.
Docking studies and molecular dynamics simulation of triazole benzene sulfonamide derivatives with human carbonic anhydrase IX inhibition activity
Authors: P. Gopinath , M. K. Kathiravan
Published: November 2021

Compound 27 as best theoritical lead interacting with the residues of hCA IX enzyme.
Cavity catalysis: modifying linear free-energy relationship under cooperative vibrational strong coupling
Authors: Lather Jyoti , Thabassum Ahammad N. K. , Singh Jaibir , George Jino
Published: November 2021

Cavity catalysis: vibrational strong coupling of solute and solvent molecules enhanced the rate of an esterification reaction. Hammett relation breaks under strong light-matter coupling conditions suggesting its potential applications in catalysis.
The effect of deuterium on the photophysical properties of DNA-stabilized silver nanoclusters
Authors: Cerretani Cecilia , Palm-Henriksen Gustav , Liisberg Mikkel B. , Vosch Tom
Published: November 2021

We investigated the effect of using D2O versus H2O as solvent on the spectroscopic properties of two NIR emissive DNA-stabilized silver nanoclusters (DNA–AgNCs).
Discovery of cell active macrocyclic peptides with on-target inhibition of KRAS signaling
Authors: Lim Shuhui , Boyer Nicolas , Boo Nicole , Huang Chunhui , Venkatachalam Gireedhar , Angela Juang Yu-Chi , Garrigou Michael , Kaan Hung Yi Kristal , Duggal Ruchia , Peh Khong Ming , Sadruddin Ahmad , Gopal Pooja , Yuen Tsz Ying , Ng Simon , Kannan Srinivasaraghavan , Brown Christopher J. , Verma Chandra S. , Orth Peter , Peier Andrea , Ge Lan , Yu Xiang , Bhatt Bhavana , Chen Feifei , Wang Erjia , Li Nianyu Jason , Gonzales Raymond J. , Stoeck Alexander , Henry Brian , Sawyer Tomi K. , Lane David P. , Johannes Charles W. , Biswas Kaustav , Partridge Anthony W.
Published: November 2021

Targeting undruggable intracellular proteins with peptides: novel on-target macrocyclic peptide inhibitors of KRAS with broad inhibition of proliferation of multiple KRAS-dependent cancer cell lines.
High-efficiency hyperfluorescent white light-emitting diodes based on high-concentration-doped TADF sensitizer matrices via spatial and energy gap effects
Authors: Duan Chunbo , Xin Ying , Wang Zicheng , Zhang Jing , Han Chunmiao , Xu Hui
Published: November 2021

A thermally activated delayed fluorescence host was developed to realize high-efficiency fluorescence white organic light-emitting diodes (WOLED) through spatial and energy gap effects.
SnO2-supported single metal atoms: a bifunctional catalyst for the electrochemical synthesis of H2O2
Authors: Jimenez-Villegas Santiago , Kelly Sara R. , Siahrostami Samira
Published: November 2021

SnO2 supported single metal atoms offer unique bifunctional catalyst materials for electrochemical synthesis of hydrogen peroxide via 2e-ORR and 2e-WOR.
Improving the oxygen evolution reaction using electronic structure modulation of sulfur-retaining nickel-based electrocatalysts
Authors: Han Man Ho , Pin Min Wook , Koh Jai Hyun , Park Jong Hyeok , Kim Jihyun , Min Byoung Koun , Lee Woong Hee , Oh Hyung-Suk
Published: November 2021

Sulfurized NiFeCo OER electrocatalysts for water splitting in alkaline conditions.
A dual-biomimetic knitted fabric with a manipulable structure and wettability for highly efficient fog harvesting
Authors: Yu Zhihua , Li Shuhui , Liu Mingming , Zhu Ruofei , Yu Mengnan , Dong Xiuli , Sun Yaxin , Fu Shaohai
Published: November 2021

A bio-inspired fabric with wedge-shaped tracks and patterned wettability was fabricated using knitting technology. The dual-biomimetic knitted fabric exhibited excellent fog harvesting performance.
Zeolite-driven Ag species during redox treatments and catalytic implications for SCO of NH3
Authors: Lopes Christian W. , Martinez-Ortigosa Joaquin , Góra-Marek Kinga , Tarach Karolina , Vidal-Moya José A. , Palomares Antonio E. , Agostini Giovanni , Blasco Teresa , Rey Fernando
Published: November 2021

The zeolite topology directs the formation of different silver species with catalytic implications for the NH3-SCO reaction.
Induction of mesenchymal stem cell differentiation by co-culturing with mature cells in double-layered 2-methacryloyloxyethyl phosphorylcholine polymer hydrogel matrices
Authors: Ishihara Kazuhiko , Kaneyasu Miu , Fukazawa Kyoko , Zhang Ren , Teramura Yuji
Published: November 2021

Mesenchymal stem cells can be encapsulated 3-dimensionally in a spontaneously forming polymer hydrogel. Differentiation of the cells is effectively induced by close-contact co-culturing with mature cells encapsulated in different polymer hydrogels.
Hyaluronic acid targeted and pH-responsive multifunctional nanoparticles for chemo-photothermal synergistic therapy of atherosclerosis
Authors: Liu Shun , Zhao Yun , Shen Meili , Hao Yujiao , Wu Xiaodong , Yao Yixuan , Li Yapeng , Yang Qingbiao
Published: November 2021

Utilizing the special physiological environment of atherosclerosis, design a stimulable response nano-drug-carrying system which can chemo-photothermal synergistic therapy of atherosclerosis.
The solvent effect modulates the formation of homogeneous polyphenol composite hydrogels with improved transparency and mechanical strength for antibacterial delayed sternal closure films
Authors: Xie Jiahui , Jin Dawei , Qiu Jiaqi , Cui Jingyuan , Yin Meng , Qu Xue
Published: November 2021

A solvent exchange (SE) method is proposed to fabricate homogeneous polyphenol toughened composite hydrogels with improved transparency, mechanical strength and antibacterial abilities for delayed sternal closure films.
Synthesis and functionalization of dendritic polyglycerol-based nanogels: application in T cell activation
Authors: Reisbeck Felix , Wedepohl Stefanie , Dimde Mathias , Schmitt Ann-Cathrin , Dernedde Jens , Álvaro-Benito Miguel , Freund Christian , Haag Rainer
Published: November 2021

Synthesis of a dPG- and NG-based nanoplatform conjugated to avidin for the multivalent display of biotinylated biomolecules. Carriers were coupled to antibodies and their capability to activate T cells was assessed, showing a multivalency effect.
Microenvironment-responsive multifunctional hydrogels with spatiotemporal sequential release of tailored recombinant human collagen type III for the rapid repair of infected chronic diabetic wounds
Authors: Hu Cheng , Liu Wenqi , Long Linyu , Wang Zhicun , Yuan Yihui , Zhang Wen , He ShuYi , Wang Jian , Yang Li , Lu Lu , Wang Yunbing
Published: November 2021

A brand-new tailored hCol III-based microenvironment-responsive hydrogel could effectively accelerate the repair and regeneration of chronic diabetic wounds by a programmed controlled release of therapeutic substance approach.
Controllable spin direction in nonmagnetic BX/MX2 (M = Mo or W; X = S, Se and Te) van der Waals heterostructures by switching between the Rashba splitting and valley polarization
Authors: Zhang Dongxue , Zhou Baozeng
Published: November 2021

A schematic of the spin FET based on the BSe/MoSe2 heterostructure. The Rashba-type spin splitting can be evoked by a positive electric field and the spin/valley Hall effect is controlled by a negative electric field.
Bi(Mg1/2Zr1/2)O3–PbZrO3–PbTiO3 relaxor ferroelectric ceramics with large and temperature-insensitive electric field-induced strain response
Authors: Jia Hongrui , Liang Zhigang , Li Zhen , Li Fei , Wang Linghang
Published: November 2021

A large strain (0.33% at 5 kV mm−1) and high temperature stability (strain variation less than 8%) were obtained simultaneously in new BMZ-PZ-PT ternary ceramics by the substitution of BMZ for PZ in PZT ceramics.
Coil–rod–coil triblock copolymers synthesized by macromolecular clicking and their compatibilizer effects in all-polymer solar cells
Authors: Otep Sultan , Tseng Yu-Cheng , Yomogita Naomasa , Chang Jia-Fu , Chueh Chu-Chen , Michinobu Tsuyoshi
Published: November 2021

Macromolecular clicking of poly(arylenebutadiynylene)s produces excellent block copolymer-based compatibilizers for all-polymer solar cells.
Optically controlled large-coercivity room-temperature thin-film magnets
Authors: Philip Anish , Zhou Yifan , Tewari Girish C. , van Dijken Sebastiaan , Karppinen Maarit
Published: November 2021

ALD/MLD enables the growth of optically-controllable room-temperature ferrimagnetic ε-Fe2O3:azobenzene superlattice thin films with excellent coercivity.
LncRNA SNHG6 knockdown inhibits cisplatin resistance and progression of gastric cancer through miR-1297/BCL-2 axis
Authors: Mei Jiazhuan , Liu Guiju , Li Ruijun , Xiao Peng , Yang Dan , Bai Hua , Hao Yibin
Published: November 2021

Cisplatin (DDP) resistance is a huge obstacle to gastric cancer (GC) treatment. Long non-coding RNAs (lncRNAs) have been manifested to exert pivotal functions in GC development. Herein, we aimed to explore the functional impact of lncRNA small nucleolar RNA host gene 6 (SNHG6) on DDP resistance and progression of GC. Quantitative real-time PCR (qRT-PCR) assay or Western blotting was performed to detect the expression of SNHG6, microRNA(miR)-1297, and epithelial–mesenchymal transition (EMT)-related factors and B-Cell Lymphoma 2 (Bcl-2) in DDP-resistant GC cells. Half inhibition concentration (IC50) to DDP, clonogenicity, apoptosis and invasion were examined via CCK-8 assay, colony formation assay, flow cytometry and Transwell assay, respectively. Target association between miR-1297 and SNHG6 or BCL-2 was demonstrated via dual-luciferase reporter assay or RIP assay. Xenograft models in nude mice were formed to investigate role of SNHG6 in vivo. We found that SNHG6 and BCL-2 were up-regulated, while miR-1297 expression was declined in GC tissues and DDP-resistant cells. Moreover, depletion of SNHG6 or gain of miR-1297 could repress DDP resistance, proliferation and metastasis of DDP-resistant cells, which was weakened by miR-1297 inhibition or BCL-2 overexpression. Besides, SNHG6 positively regulated BCL-2 expression by sponging miR-1297. Furthermore, SNHG6 knockdown repressed GC tumor growth in vivo. In a word, lncRNA SNHG6 knockdown had inhibitory effects on DDP resistance and progression of GC by sponging miR-1297, highlighting its potential in GC treatment.
Regulation of spatially restricted gene expression: linking RNA localization and phase separation
Authors: O'Connell Liam C. , Mowry Kimberly L.
Published: November 2021

Subcellular restriction of gene expression is crucial to the functioning of a wide variety of cell types. The cellular machinery driving spatially restricted gene expression has been studied for many years, but recent advances have highlighted novel mechanisms by which cells can generate subcellular microenvironments with specialized gene expression profiles. Particularly intriguing are recent findings that phase separation plays a role in certain RNA localization pathways. The burgeoning field of phase separation has revolutionized how we view cellular compartmentalization, revealing that, in addition to membrane-bound organelles, phase-separated cytoplasmic microenvironments — termed biomolecular condensates — are compositionally and functionally distinct from the surrounding cytoplasm, without the need for a lipid membrane. The coupling of phase separation and RNA localization allows for precise subcellular targeting, robust translational repression and dynamic recruitment of accessory proteins. Despite the growing interest in the intersection between RNA localization and phase separation, it remains to be seen how exactly components of the localization machinery, particularly motor proteins, are able to associate with these biomolecular condensates. Further studies of the formation, function, and transport of biomolecular condensates promise to provide a new mechanistic understanding of how cells restrict gene expression at a subcellular level.
Diagnostik und Behandlung von Demenzsyndromen in der klinischen Neuropsychologie
Authors: Werheid Katja
Published: November 2021

Die demografische Alterung, gepaart mit einer wachsenden Inanspruchnahme ambulanter Psychotherapie in der „Generation 60+“, stellt Psychotherapeut*innen immer häufiger vor die Frage, ob kognitive Defizite ihrer Patient*innen altersgemäß oder bereits Frühzeichen eines Demenzsyndroms sind. Ist eine Psychotherapie indiziert, wenn ja welche, und kann sie wirksam sein? Der Beitrag beleuchtet diese Fragen aus neuropsychologischer Sicht.
Stimulationsverfahren und Neurofeedback: neue Möglichkeiten zur Therapie und Rehabilitation?
Authors: Jäncke Lutz
Published: November 2021

Das Gehirn des Menschen bestimmt unser Denken, Handeln und Fühlen. Ebenso wie außergewöhnliche kognitive und motorische Leistungen werden psychiatrische und psychopathologische Probleme durch neurophysiologische und neuroanatomische Besonderheiten des Gehirns bestimmt. Eine Idee, psychische oder neurologische Störungen zu behandeln ist, die Gehirnaktivität durch unterschiedliche invasive oder nicht-invasive Verfahren zu beeinflussen.
Längerfristige Folgen neuropsychologischer Störungen im Kindes- und Jugendalter
Authors: Lidzba Karen
Published: November 2021

Die Neuropsychologie des Kindes- und Jugendalters beschäftigt sich mit einem sehr vielfältigen Spektrum an Störungsbildern, Entwicklungsstufen und Fragestellungen. Akut auftretende neurologische Erkrankungen bedürfen je nach Entwicklungsstufe unterschiedlicher diagnostischer und therapeutischer Maßnahmen sowie verschiedenster Ansätze zur Reintegration. Der Beitrag stellt wichtige Grundprinzipien der Kinder- und Jugendneuropsychologie dar.
Neuropsychologie – Angebote im Internet für Betroffene und Experten
Authors: Kupferschmitt Alexa
Published: November 2021

Wahrnehmung, motorische Geschicklichkeit, Gedächtnis, Sprache und Denken, aber auch der Ausdruck von Emotionen, Sozialverhalten oder psychische Symptome wie die Depressivität sind Interessensgebiete der Neuropsychologie. Bei neurologischen Defiziten benötigen Betroffene Hilfe durch kompetente Ansprechpartner und dies möglichst niedrigschwellig.
Neuropsychologie
Authors: Gehn Jana
Published: November 2021

Definitionen, Fakten, Relevantes – die PiD-Essentials fassen die wichtigsten Informationen zum Thema des Heftes knapp und übersichtlich für Sie zusammen.
Die Begutachtung des leichten Schädel-Hirn-Traumas
Authors: Plohmann Andrea M.
Published: November 2021

Leichte Schädel-Hirn-Traumen (SHT) sind häufig. Kognitive, affektive und somatische Folgen gelten als vorübergehend. Dennoch sind Sachverständige immer wieder mit der Begutachtung von Patient*innen konfrontiert, die anhaltende Gesundheitsstörungen geltend machen. Der Beitrag beleuchtet die Komplexität des Sachverhalts und insbesondere einer neuropsychologischen Begutachtung.
Neuropsychologische Symptome bei psychischen Erkrankungen
Authors: Aschenbrenner Steffen , Weisbrod Matthias
Published: November 2021

Neuropsychologische Symptome treten bei fast allen psychischen Erkrankungen auf. In der Regel sind sie so deutlich ausgeprägt, dass sie die Alltagsbewältigung der Patient*innen deutlich beeinflussen, eine berufliche Integration limitieren und die psychotherapeutische Behandlung erschweren. Sie bedürfen daher einer spezifischen neuropsychotherapeutischen Behandlung.
Therapeutische Beziehung in der Neuropsychologie
Authors: Völzke Volker
Published: November 2021

Die Rolle der therapeutischen Beziehung bzw. Allianz hat sich im Lauf meiner therapeutischen Arbeit in der Neuropsychologie verändert. Sie hat deutlich an Bedeutung gewonnen. Der nachfolgende Erfahrungsbericht soll entsprechende Aspekte verdeutlichen.
Das akute Koronarsyndrom in der präklinischen Notfallmedizin
Authors: Schieffer Bernhard , Kreutz Julian , Markus Birgit , Schäfer Ann-Christin
Published: November 2021

Das akute Koronarsyndrom (ACS) ist eine häufige Arbeitsdiagnose in der präklinischen Notfallmedizin. Durch den potenziell lebensbedrohlichen Verlauf sind eine schnelle Diagnostik und Einleitung von Therapiemaßnahmen entscheidend. Dabei stehen extrahospital antithrombotische Medikamente und eine Therapie der Begleitsymptomatik im Vordergrund. Ein zügiger Transport in die Klinik für eine perkutane Koronarintervention (PCI) ist notwendig.
Clinical impact of whole-body 68Ga-PSMA I&T PET/CT: lesion frequency and added benefit in lower extremities
Authors: Stolzenbach Lara Franziska , Löcherbach Florian , Maurer Tobias , Berliner Christoph , Wargenau Katharina , Pose Randi , Steuber Thomas , Tian Zhe , Budäus Lars , Tilki Derya , Graefen Markus , Köhler Daniel , Karakiewicz Pierre I. , Sauer Markus , Apostolova Ivayla Ilieva
Published: November 2021

Aim Few small-scaled studies performed systematic analysis of the benefits of extending prostate specific membrane antigen positron-emission tomography/ computed tomography (68Ga-PSMA I&T PET/CT) to the lower extremities in prostate cancer (PCa) patients. We hypothesized that 68Ga-PSMA I&T PET/CT positive lesions are rare in lower extremities of prostate cancer (PCa) patients, the clinical implication is negligible and may therefore be omitted.

Methods We retrospectively analyzed 1,068 PCa patients who received 68Ga-PSMA I&T PET/CT in a single institution (2016–2018). Of those, 285 (26.7%) were newly diagnosed, 529 (49.5%) had biochemical recurrence (BCR) and 254 (23.8%) were castration-resistant prostate cancer (CRPC) patients.

Results Of 1,068 68Ga-PSMA I&T PET/CTs, positive lesions in the lower extremities were identified in 6.9% patients (n=74). Positive lesions in the lower extremities were most common in CRPC patients (19.7%; n=50), followed by newly diagnosed (3.2%; n=9) and BCR (2.8%; n=15) PCa patients. Only 3 patients presented with exclusive lesions in the lower extremities, respectively 0.8% (n=2) in CRPC and 0.4% (n=1) in newly diagnosed PCa. Both CRPC (94.1%, n=47) and BCR (80.0%, n=12) patients with PSMA-positive lesions predominantly received systemic therapy.

Conclusion Identification of lower extremities lesions with PSMA PET/CT is uncommon and exclusive lesions are rare. PSMA PET/CT findings of the lower extremities did not change therapy management. Thus, scanning of the lower extremities can be omitted in standard protocols.
Anästhesiologische Lehre in Zeiten von Corona – von der Präsenzlehre zum Hybridmodell
Authors: Gröne Julie , Wagner Jasmin , Lotz Christopher , Haller Elisabeth , Skazel Tobias , Meybohm Patrick , Happel Oliver , Wurmb Thomas , König Sarah , Kranke Peter
Published: November 2021

Am 14.03.2020 wurde eine erste bayernweite Ausgangsbeschränkung verhängt und der Hochschullehrbetrieb in seiner bekannten Form drastisch eingeschränkt. Für Intensivmediziner und Anästhesisten ergab sich vielerorts durch die außergewöhnliche Inanspruchnahme bei der Behandlung kritisch kranker Patienten und die Neustrukturierung und Aufrechterhaltung des Lehrbetriebs ein besonderes Spannungsfeld. Wir berichten über die Neuausrichtung des Seminars Anästhesie in einem online abgehaltenen Flipped Classroom und die Entwicklung hin zu einem Hybridmodell. Es konnte so unter schwierigen Rahmenbedingungen eine gleichwertige Wissensvermittlung gewährleistet und gleichzeitig das Lehrkonzept weiterentwickelt werden.
Effektivität stationärer und teilstationärer
psychosomatisch-psychotherapeutischer Behandlung
Authors: Hirt Anne-Regina , Croy Ilona , Joraschky Peter , Kreßner-Kiel Denise , Schellong Julia , Wolff Silvia , Keller Andrea , Hanßke Amalia , Noack René , Schiling Christoph , Coenen Anne , Weidner Kerstin
Published: November 2021

Fragestellung (Teil-)stationäre Psychotherapie ist in Deutschland
gut implementiert. Um Wirksamkeitsfaktoren und Effekte besser zu verstehen, sind
Effektivitätsstudien notwendig. Diese naturalistische Studie untersucht
die Effektivität stationärer und teilstationärer
Psychotherapie sowie patientenzentrierte und störungsbezogene
Einflussfaktoren auf individuelle Symptomverbesserungen.

Methoden Analysiert werden Patient*innen einer
psychosomatisch-psychotherapeutischen Universitätsklinik, die in den
Jahren 2015 bis 2019 behandelt wurden und das BSI-18 entweder bei Aufnahme und
Entlassung (N=1366) oder bei Aufnahme und Dreimonatskatamnese
(N=497) ausfüllten.

Ergebnisse Die Verbesserungen in der globalen Symptomschwere zeigen
moderate Effektstärken. Deskriptiv sind diese größer bei
teilstationärer als bei stationärer Behandlung–besonders
im Follow-up-Vergleich (direkt nach Entlassung:
dstationär=0.401, dteilstationär=0,482; drei
Monate nach Entlassung: dstationär=0,403,
dteilstationär=0,807). Die teilstationären unterscheiden
sich signifikant von den stationären Patient*innen –
gering in Alter, Beschäftigungsstatus, Arbeitsfähigkeit und
initialen Symptombelastungen, moderat in der Anzahl psychischer
Komorbiditäten und stark in ihren Hauptdiagnosen. Soziodemographische
Faktoren zeigen keinen, die initiale Symptomschwere einen moderaten positiven
und die Anzahl psychischer Komorbiditäten einen komplexen Einfluss auf
die Symptomverbesserungen.

Diskussion Allgemein bestätigt diese Studie die Wirksamkeit
(teil-)stationärer psychosomatischer Therapie. Die Relevanz
teilstationärer Angebote wird vor dem Hintergrund von Kosteneffizienz
und guter Integration in den Alltag betont, unter Beachtung individueller
Behandlungsindikationen.
Zufall oder nicht – Teil 2: Empirische Forschung in der Physiotherapie
Authors: Nilsson Svenja , Natalie Pankrath
Published: November 2021

Mit statistischen Verfahren lässt sich beispielsweise berechnen, ob eine Intervention einer anderen überlegen ist. Warum es nie eine hundertprozentige Sicherheit gibt und was man tun kann, um die Irrtumswahrscheinlichkeit möglichst klein zu halten, erläutert der zweite Teil des Artikels.
Langjährig begleiten – Therapiemanagement bei Morbus Perthes
Authors: Huybrechts Mark
Published: November 2021

Schmerzen, Hinken und Bewegungsstörungen sind die Kardinalsymptome bei Morbus Perthes. Vor allem Kinder zwischen vier und acht Jahren erkranken an der nicht infektiösen Durchblutungsstörung der proximalen Femurepiphyse. Heute weiß man, dass gezielte Entlastungen in Schmerzphasen und eine angepasste sportliche Aktivität wichtig sind.
Liebe Leserinnen und Leser,
Authors: Buchner Helmut
Published: November 2021

das Jahr neigt sich dem Ende zu. Wie war das Jahr?
A Study on the Prediction of Reproductive Outcomes in Frozen Embryo Transfer Cycles by Calculating the Volume of Uterine Junctional Zone with Three-Dimensional Ultrasound
Authors: Liu Yan , Wang Lei , Wang MeiXian , Jiang Yu , Xia TingTing , Yue QingXiong , Sha YuJia , Huang Ying
Published: November 2021

Purpose To prospectively study the inﬂuence of the volume of the uterine junctional zone (JZ) as a novel predictor of reproductive outcomes in frozen embryo transfer cycles.

Methods Among the first 30 patients, intra- and interobserver repeatability was evaluated and expressed as a coefficient of repeatability. The same classification system was used to evaluate the JZ of 142 infertility patients undergoing in vitro fertilization (IVF). Ultrasonography was performed on the day before transplantation. The three-dimensional (3D) volume images were then analyzed to obtain the volume of the endometrium (EV), the average thickness of the JZ on the coronal plane, and the volume of the JZ (JZV). The JZV was then divided by the EV. These parameters were compared with the outcomes of clinical pregnancy.

Results The 3D image showed that the JZ achieved a good intra- and interobserver consistency (k = 0.862, k = 0.694). The total pregnancy rate was 47%. There was a highly significant difference between pregnant and non-pregnant women with respect to age (p < 0.001), JZV (p = 0.003), and JZV/EV (p < 0.001) on the day before transplantation. Age and JZV/EV were independent factors for predicting the success of IVF transplantation (p = 0.010, p = 0.016). The area under the ROC curve of JZV/EV in predicting clinical pregnancy was 0.688, the cut-off value was 0.54, the sensitivity was 83.8%, and the specificity was 50.0%.

Conclusion Age and JZV/EV are independent factors for predicting the success of frozen embryo transfer cycles in IVF. A smaller JZV/EV was more beneficial for clinical pregnancy.