bluuebunny/crossref_metadata_2025 huggingface dataset:
Proteomic Analysis of the Molecular Mechanisms of Chlorpromazine
Inhibiting Migration of Oral Squamous Cell Carcinoma
Authors: Zhang Nannan , Liu Junzhi , Dong Qiuping , Liu Chen , Liang Xinyu , Tang Peiyuan , Liang Zheng
Published: February 2024

Background:

Oral squamous cell carcinoma (OSCC) is a common malignant tumor of
the head and neck region known for its high metastatic and invasive potential. Chlorpromazine
(CPZ) has been shown to inhibit the growth of oral cancer cells. However, the effects of CPZ on
OSCC migration and its underlying molecular mechanisms remain unclear.

Objective:

We aimed to identify global protein changes and potential core proteins involved in
CPZ-mediated inhibition of migration in SCC-15 cells using proteomics.

Methods:

We assessed the effect of CPZ on SCC-15 using CCK-8 assays and wound healing experiments.
Next, we performed LC-MS-based proteomic analysis to identify protein alterations in
SCC-15 cells treated with CPZ at different times. Differential expression proteins (DEPs) were
identified and subjected to bioinformatics analysis using GO, KEGG, and PPI tools. Key candidate
proteins were selected and validated using the TCGA-HNSCC database and molecular docking.

Results:

It was found that 20μm of CPZ had no effect on cell proliferation, but inhibited cell migration.
A total of 4748 proteins were identified by Proteomics, among which 56 DEPs were identified,
including 34 upregulated proteins and 22 downregulated proteins. Three proteins (RPF2,
ACTB, and TGFBI) were identified as key candidate proteins associated with cell adhesion and
migration in oral cancer cells.

Conclusion:

CPZ may affect the expression of RPF2, ACTB, and TGFBI proteins and change the
extracellular matrix and cell adhesion function, thus inhibiting the migration of SCC-15 cells. The
results of this study provide a robust basis for further research on the molecular mechanism of
CPZ to inhibit the migration of OSCC.
Nanotechnology-based Approaches for Breast Cancer
Authors: Prabha Shashi , Kumar Panda Pritish , Singh Sumita , Ahmed Bahar
Published: February 2024

One common cancer among women is breast cancer. Chemotherapy, radiation therapy, and
surgery have historically been used as breast cancer treatments. Thanks to recent technological advancements,
we have been able to progressively comprehend the complexity and heterogeneity of
diseases, which has led to the development of more effective treatments for many conditions. Working
with variably shaped nanoparticles, nanotechnology has recently enabled us to work on tumor
targeting and drug delivery, and it has undoubtedly helped to reduce the spread and death of breast
cancer. The efficacy of treatment for breast cancer can be increased by a variety of target therapies
made possible by nanotechnology. The current review discusses the advantages and disadvantages of
nanotechnology-based therapy for breast cancer while also highlighting the disease's current state.
The article will provide an overview of the current strategy available for better treatment of breast
cancer and aid in understanding the various drug delivery systems designed to provide effective
treatment for the disease. By utilizing cutting-edge technologies and early screening, breast cancer
fatalities can be decreased. Drug delivery methods based on nano carriers enable medication to reach
the target site at the ideal concentration with the least amount of harmful side effects.
Catalyst-free Aloe Vera-promoted Cyclization of 2-Amino-azarenes with Phenacyl Bromide
Authors: Baranwal Jyoti , Singh Swastika , Kushwaha Smriti , Jyoti Archana
Published: February 2024

Introduction:

By condensing 2-aminothiazole and phenacyl bromide, a novel catalystfree
synthetic approach for the synthesis of imidazo[2,1-b]thiazole derivatives has been developed.

Methods:

In this work, aloe vera/water (3:2) is used as a reusable, environmentally benign, greenpromoting
media to synthesize desired products. This method enables the synthesis of a diverse
range of aryl-substituted imidazo[2,1-b]thiazoles.

Results:

This solvent system demonstrates remarkable efficiency and offers numerous advantages,
including shorter reaction times, the absence of side product formation, costeffectiveness,
excellent atom efficiency, straightforward operation, and high yields.

Conclusion:

In conclusion, we successfully developed a green protocol for the environmentally
benign synthesis of imidazo[2,1-b]thiazole derivatives using aloe vera water as green-promoting
media.
Impact of High Pressure Processing on the Safety and Quality of Food Products: A Review
Authors: Khouryieh Hanna
Published: February 2024

High pressure processing (HPP) has become a practical food processing technique
that meets the preferences of consumers seeking lightly processed, convenient, and fresh-tasting
food options. This paper reviewed the latest research on the impact of HPP on the safety and
quality of food products. The use of HPP has been showing favorable growth in the food industry
primarily due to its potential to not only enhance the nutritional content and sensory attributes
of food products but also to substantially extend their shelf-life and bolster safety standards.
HPP is the most used among non-thermal food processing technologies. While its direct application
to milk for consumption falls short of delivering consistent quality, it proves effective as a
pre-treatment step and in products using milk as a primary ingredient. In the context of meat
production, HPP reduces microbial loads and extends shelf-life, yet concerns persist regarding
its impact on product quality. The absence of in-depth studies regarding the attributes of carrots
that support pathogen regeneration emphasizes the need for comprehensive research in this area,
which could have far-reaching implications for similar fruit and vegetable products. This review
underscores the need for a balanced assessment of HPP's effects on food safety and quality, offering
insights that can guide the food industry in adopting this technology while ensuring consumer
satisfaction and safety.
APRENDIZAGEM SIGNIFICATIVA E FUNÇÕES INORGÂNICAS
Authors: Silva Passos Blanchard , Vasconcelos Ana Karine Portela
Published: February 2024

O presente artigo propõe uma Sequência Didática (SD) que utiliza Mapas Conceituais (MC) para o ensino de funções inorgânicas com o objetivo de promover uma aprendizagem significativa. Os MC se mostram de grande relevância como uma estratégia pedagógica, incentivando a participação ativa dos estudantes e a construção do conhecimento. A SD proposta compreende a alternância entre aulas teóricas e atividades em grupo, divididas em sete etapas distintas, cada uma delas acompanhada de uma pergunta norteadora que direciona o processo de elaboração de Mapas Conceituais a partir de textos relacionados aos temas geradores "A Importância da Digestão: Desvendando o Papel das Funções Inorgânicas" e "Os Perigos da Chuva Ácida". Essa abordagem visa não apenas transmitir conhecimento teórico, mas também estimular os estudantes a desenvolver um entendimento significativo e a se envolver ativamente no processo de aprendizagem.
COMPLEXIDADE, INTERCULTURALIDADE E EDUCAÇÃO
Authors: De Assis Lago Paulo , Pereira de Figueiredo Renato
Published: February 2024

O paradigma do pensamento moderno, um pensamento monocultural e ocidentalizado no qual está pautada a cultura educacional hegemônica, precisa ser superado. Partindo desse ponto, o presente artigo reflete, com base em pensadores contemporâneos, como Edgar Morin, Maria da Conceição Xavier de Almeida, Vera Maria Candau, Vandana Shiva e Ailton Krenak, eixos de problematização fundamentais para uma educação pautada nos princípios da complexidade e da interculturalidade, necessária para a construção de um pensar pertinente à concepção de uma comunidade de destino terrena. É debruçando-se nesse desafio que desenvolvemos aqui três eixos de problematização: O eixo ontológico, epistemológico e ético. Para isso, é necessário aprender a religar saberes apartados, de culturas distintas, bem como construir uma cosmovisão multifacetada, mais plural, capaz de desenvolver uma identidade comum menos antropocêntrica e monolítica que inclua seres e culturas diversas.
ESCOLA NORMAL DO CEARÁ
Authors: Stascxak Francinalda Machado , Mouta Limária Araújo , Costa Maria Aparecida Alves da
Published: February 2024

Conhecer as mulheres que estiveram à frente da direção da Escola Normal do Ceará no primeiro centenário da instituição a partir da perspectiva de descrever e de problematizar a história da educação cearense, sobretudo a partir da educação feminina em um recorte temporal que compreende parte dos séculos XIX e XX, é o objetivo deste estudo. Assim, desenvolvemos uma pesquisa bibliográfica e documental. Com isso, destacamos a contribuição à frente da direção da Escola Normal do Ceará na figura de cinco mulheres, nesta ordem de atuação: Elvira Pinho (1895), Edith Braga (1934-1935), Susana Borges (1960), Olívia Rodrigues (1962-1966) e Maria Eldair Freitas (1967-1987). Consideramos que, apesar de a Escola Normal ter sido uma instituição voltada sobretudo à educação feminina, nos seus primeiros cem anos de existência, poucas foram as mulheres em sua liderança.
Attrition Rates in HIV Viral Load Monitoring and Factors Associated With Overdue Testing Among Children Within South Africa’s Antiretroviral Treatment Program: Retrospective Descriptive Analysis
Authors: Haeri Mazanderani Ahmad , Radebe Lebohang , Sherman Gayle G
Published: February 2024

Background

Numerous studies in South Africa have reported low HIV viral load (VL) suppression and high attrition rates within the pediatric HIV treatment program.

Objective

Using routine laboratory data, we evaluated HIV VL monitoring, including mobility and overdue VL (OVL) testing, within 5 priority districts in South Africa.

Methods

We performed a retrospective descriptive analysis of National Health Laboratory Service (NHLS) data for children and adolescents aged 1-15 years having undergone HIV VL testing between May 1, 2019, and April 30, 2020, from 152 facilities within the City of Johannesburg, City of Tshwane, eThekwini, uMgungundlovu, and Zululand. HIV VL test–level data were deduplicated to patient-level data using the NHLS CDW (Corporate Data Warehouse) probabilistic record-linking algorithm and then further manually deduplicated. An OVL was defined as no subsequent VL determined within 18 months of the last test. Variables associated with the last VL test, including age, sex, VL findings, district type, and facility type, are described. A multivariate logistic regression analysis was performed to identify variables associated with an OVL test.

Results

Among 21,338 children and adolescents aged 1-15 years who had an HIV VL test, 72.70% (n=15,512) had a follow-up VL test within 18 months. Furthermore, 13.33% (n=2194) of them were followed up at a different facility, of whom 3.79% (n=624) were in a different district and 1.71% (n=281) were in a different province. Among patients with a VL of ≥1000 RNA copies/mL of plasma, the median time to subsequent testing was 6 (IQR 4-10) months. The younger the age of the patient, the greater the proportion with an OVL, ranging from a peak of 52% among 1-year-olds to a trough of 21% among 14-year-olds. On multivariate analysis, 2 consecutive HIV VL findings of ≥1000 RNA copies/mL of plasma were associated with an increased adjusted odds ratio (AOR) of having an OVL (AOR 2.07, 95% CI 1.71-2.51). Conversely, patients examined at a hospital (AOR 0.86, 95% CI 0.77-0.96), those with ≥2 previous tests (AOR 0.78, 95% CI 0.70-0.86), those examined in a rural district (AOR 0.63, 95% CI 0.54-0.73), and older age groups of 5-9 years (AOR 0.56, 95% CI 0.47-0.65) and 10-14 years (AOR 0.51, 95% CI 0.44-0.59) compared to 1-4 years were associated with a significantly decreased odds of having an OVL test.

Conclusions

Considerable attrition occurs within South Africa’s pediatric HIV treatment program, with over one-fourth of children having an OVL test 18 months subsequent to their previous test. In particular, younger children and those with virological failure were found to be at increased risk of having an OVL test. Improved HIV VL monitoring is essential for improving outcomes within South Africa’s pediatric antiretroviral treatment program.
Mining Clinical Notes for Physical Rehabilitation Exercise Information: Natural Language Processing Algorithm Development and Validation Study
Authors: Sivarajkumar Sonish , Gao Fengyi , Denny Parker , Aldhahwani Bayan , Visweswaran Shyam , Bove Allyn , Wang Yanshan
Published: February 2024

Background

The rehabilitation of a patient who had a stroke requires precise, personalized treatment plans. Natural language processing (NLP) offers the potential to extract valuable exercise information from clinical notes, aiding in the development of more effective rehabilitation strategies.

Objective

This study aims to develop and evaluate a variety of NLP algorithms to extract and categorize physical rehabilitation exercise information from the clinical notes of patients who had a stroke treated at the University of Pittsburgh Medical Center.

Methods

A cohort of 13,605 patients diagnosed with stroke was identified, and their clinical notes containing rehabilitation therapy notes were retrieved. A comprehensive clinical ontology was created to represent various aspects of physical rehabilitation exercises. State-of-the-art NLP algorithms were then developed and compared, including rule-based, machine learning–based algorithms (support vector machine, logistic regression, gradient boosting, and AdaBoost) and large language model (LLM)–based algorithms (ChatGPT [OpenAI]). The study focused on key performance metrics, particularly F1-scores, to evaluate algorithm effectiveness.

Results

The analysis was conducted on a data set comprising 23,724 notes with detailed demographic and clinical characteristics. The rule-based NLP algorithm demonstrated superior performance in most areas, particularly in detecting the “Right Side” location with an F1-score of 0.975, outperforming gradient boosting by 0.063. Gradient boosting excelled in “Lower Extremity” location detection (F1-score: 0.978), surpassing rule-based NLP by 0.023. It also showed notable performance in the “Passive Range of Motion” detection with an F1-score of 0.970, a 0.032 improvement over rule-based NLP. The rule-based algorithm efficiently handled “Duration,” “Sets,” and “Reps” with F1-scores up to 0.65. LLM-based NLP, particularly ChatGPT with few-shot prompts, achieved high recall but generally lower precision and F1-scores. However, it notably excelled in “Backward Plane” motion detection, achieving an F1-score of 0.846, surpassing the rule-based algorithm’s 0.720.

Conclusions

The study successfully developed and evaluated multiple NLP algorithms, revealing the strengths and weaknesses of each in extracting physical rehabilitation exercise information from clinical notes. The detailed ontology and the robust performance of the rule-based and gradient boosting algorithms demonstrate significant potential for enhancing precision rehabilitation. These findings contribute to the ongoing efforts to integrate advanced NLP techniques into health care, moving toward predictive models that can recommend personalized rehabilitation treatments for optimal patient outcomes.
The Most Effective Interventions for Classification Model Development to Predict Chat Outcomes Based on the Conversation Content in Online Suicide Prevention Chats: Machine Learning Approach (Preprint)
Authors: Salmi Salim , Mérelle Saskia , Gilissen Renske , van der Mei Rob , Bhulai Sandjai
Published: February 2024

BACKGROUND

For the provision of optimal care in a suicide prevention helpline, it is important to know what contributes to positive or negative effects on help seekers. Helplines can often be contacted through text-based chat services, which produce large amounts of text data for use in large-scale analysis.

OBJECTIVE

We trained a machine learning classification model to predict chat outcomes based on the content of the chat conversations in suicide helplines and identified the counsellor utterances that had the most impact on its outputs.

METHODS

From August 2021 until January 2023, help seekers (N=6903) scored themselves on factors known to be associated with suicidality (eg, hopelessness, feeling entrapped, will to live) before and after a chat conversation with the suicide prevention helpline in the Netherlands (113 Suicide Prevention). Machine learning text analysis was used to predict help seeker scores on these factors. Using 2 approaches for interpreting machine learning models, we identified text messages from helpers in a chat that contributed the most to the prediction of the model.

RESULTS

According to the machine learning model, helpers’ positive affirmations and expressing involvement contributed to improved scores of the help seekers. Use of macros and ending the chat prematurely due to the help seeker being in an unsafe situation had negative effects on help seekers.

CONCLUSIONS

This study reveals insights for improving helpline chats, emphasizing the value of an evocative style with questions, positive affirmations, and practical advice. It also underscores the potential of machine learning in helpline chat analysis.
Effect of Spironolactone on Kidney Function in Kidney Transplant Recipients (the SPIREN trial)
Authors: Mortensen Line A. , Jespersen Bente , Helligsoe Anne Sophie L. , Tougaard Birgitte , Cibulskyte-Ninkovic Donata , Egfjord Martin , Boesby Lene , Marcussen Niels , Madsen Kirsten , Jensen Boye L. , Petersen Inge , Bistrup Claus , Thiesson Helle C.
Published: February 2024

Key Points

Spironolactone is safe for kidney transplant patients.

Spironolactone reduces kidney function by an acute effect, whereafter it remains stable.

Spironolactone does not affect the progression of interstitial fibrosis in protocol biopsies.

Background

Long-term kidney allograft survival is hampered by progressive interstitial fibrosis and tubular atrophy. The SPIREN trial tested the hypothesis that the mineralocorticoid receptor antagonist spironolactone stabilizes kidney function and attenuates glomerular barrier injury in kidney transplant patients treated with calcineurin inhibitors.

Methods

We conducted a randomized, placebo-controlled, double-blind clinical trial including 188 prevalent kidney transplant patients. Patients were randomized to spironolactone or placebo for 3 years. GFR was measured along with proteinuria and kidney fibrosis. The primary end point was change in measured GFR. Secondary outcomes were 24-hour proteinuria, kidney allograft fibrosis, and cardiovascular events. Measured GFRs, 24-hour proteinuria, and BP were determined yearly. Kidney biopsies were collected at baseline and after 2 years (n=48). Fibrosis was evaluated by quantitative stereology and classified according to Banff.

Results

The groups were comparable at baseline except for slightly older allografts in the spironolactone group. Spironolactone reduced measured GFRs (up to –7.6 [95% confidence interval, −10.9 to −4.3] ml/min compared with placebo) independently of time since transplantation and BP with no effect on the kidney function curve over time and reduced 24-hour proteinuria after 1 year. There was no significant effect of spironolactone on the development of interstitial fibrosis.

Conclusions

Spironolactone added to standard therapy for 3 years in kidney transplant patients did not improve kidney function, long-term proteinuria, or interstitial fibrosis.

Clinical Trial registration number

NCT01602861.
A Research on the Teaching Reform of Integrating Cross Culture, Critical Thinking, Value Cultivation and Multiple Competences for English Majors
Authors: Jinlin Gao
Published: February 2024

In order to address the long-standing issues in English language teaching, including “focusing on language knowledge and skills”, “weakness in cross-cultural communication abilities”, “prioritizing language over culture”, “absence of critical thinking”, “uniformity in competences” and “separation of knowledge and affection”, a new model has been proposed based on the interpretation of key national policy documents. The model of “Integrating Cross Culture, Critical Thinking, Value Cultivation and Multiple Competences” (ICCVM in short) (Note 1) aims to implement educational reforms from various perspectives, such as talent cultivation, curriculum frameworks, textbook adaptation, teaching methods, and assessment models.Breaking away from the traditional language-centered approach, this model places moral value cultivation at its core. It systematically develops students’ innovative and research abilities, as well as their collaboration and negotiation skills, through cross-cultural linguistic activities and critical thinking language activities. The model strives to achieve an educational goal that integrates value shaping, knowledge imparting, and competence cultivation into one cohesive process. It is anticipated that this will enhance the overall quality of talent cultivation in English major, producing students who possess outstanding English skills and diverse competencies, profound cultural knowledge, as well as both an international perspective and a sense of Chinese identity.
A Probe into the Integrated Learning Model of Academic English “Writing + Critical Thinking” in Sino-Foreign Joint Education
Authors: YU Shumeng , Zhang Liuyi
Published: February 2024

This research attempts to reconstruct an integrated learning model of academic English “writing + critical thinking”, which is better targeted at talent cultivation in Sino-foreign Joint Education, a prominent entity in China’s higher education. This model, under the guidance of six critical thinking skills from the Delphi Report, boasts 3 vital revisions in the teaching process of academic writing: critical reading, exemplar writing methodology, and a co-constructed updated version of academic English “writing + critical thinking” marking criteria. This could enhance critical thinking dispositions and skills of students in Sino-foreign Joint Education who, with the help of these skills, can ultimately develop into critical, globally literate and competitive talents. This research could benefit the teaching reform in Sino-foreign Joint Education and its Academic English courses.
E3 ubiquitin ligase components in GtoPdb v.2023.3
Authors: Faccenda Elena , Layfield Robert
Published: February 2024

Ubiquitination (a.k.a. ubiquitylation) is a protein post-translational modification that typically requires the sequential action of three enzymes: E1 (ubiquitin-activating enzymes), E2 (ubiquitin-conjugating enzymes), and E3 (ubiquitin ligases) [48]. Ubiquitination of proteins can target them for proteasomal degradation, or modulate cellular processes including cell cycle progression, transcriptional regulation, DNA repair and signal transduction. E3 ubiquitin ligases, of which there are >600 in humans, are a family of highly heterogeneous proteins and protein complexes that recruit ubiquitin-loaded E2 enzymes to mediate transfer of the ubiquitin molecule from the E2 to protein substrates. Target substrate specificity is determined by a substrate recognition subunit within the E3 complex. E3 ligases are being exploited as pharmacological targets to facilitate targeted protein degradation (TPD), as an alternative to small molecule inhibitors [5], through the development of proteolysis targeting chimeras (PROTACs) and molecular glues.
SLC23 family of ascorbic acid transporters in GtoPdb v.2023.3
Authors: May James M.
Published: February 2024

Predicted to be 12 TM segment proteins, members of this family transport the reduced form of ascorbic acid (while the oxidized form may be handled by members of the SLC2 family (GLUT1/SLC2A1, GLUT3/SLC2A3 and GLUT4/SLC2A4). phloretin is considered a non-selective inhibitor of these transporters, with an affinity in the micromolar range [1].
Prolactin-releasing peptide receptor in GtoPdb v.2023.3
Authors: Caruso Vanni , Hills Rebecca , Lagerstrom Malin , Onaka Tatsushi , Schiöth Helgi
Published: February 2024

The precursor (PRLH, P81277) for PrRP generates 31 and 20-amino-acid versions. QRFP43 (43RFa) (named after a pyroglutamylated arginine-phenylalanine-amide peptide) is a 43 amino acid peptide derived from QRFP (P83859) and is also known as P518 or 26RFa. RFRP is an RF amide-related peptide [31] derived from a FMRFamide-related peptide precursor (NPVF, Q9HCQ7), which is cleaved to generate neuropeptide SF, neuropeptide RFRP-1, neuropeptide RFRP-2 and neuropeptide RFRP-3 (neuropeptide NPVF).
Perspectiva demográfica y empleo
Authors: Videgain Martínez Ana Karina
Published: February 2024

El comportamiento económico de las personas varía según las etapas de su curso de vida en que se encuentran, así como sus necesidades, demandas y niveles de participación en los procesos productivos. Por lo cual, los cambios en la estructura por edades impactan con fuerza los procesos económicos y modifica la composición y el peso de demandas específicas asociadas a ciertos grupos de edad. De esta forma, una particular estructura por edad, además de un cierto nivel de crecimiento, conforma distintas tasas de dependencia que dan forma a las demandas a las que la economía debe hacer frente, a la vez que dota a los procesos productivos de una fuerza de trabajo determinada.
Análisis de regresión: Enfoque del desempeño de la curva de ruptura en un sistema dinámico
Authors: Burgos Huezo Humberto Edgardo , Garfias Soliz Jaime Max , Martel Richard , Salas García Javier
Published: February 2024

La presencia de arsénico en agua de consumo humano es un problema sanitario que ha recibido interés de investigación en las últimas décadas. El objetivo de este trabajo fue evaluar la incidencia que tienen el análisis de regresión lineal y no lineal, sobre la estimación de los parámetros de adsorción de diversos modelos matemáticos, para explicar el proceso dinámico de remoción de contaminantes. Para ello, se utilizaron zeolitas químicamente modificadas para la adsorción de As(V) en un sistema dinámico de columna de lecho fijo. La cinética de adsorción se analizó con los modelos lineales y no lineales de Thomas y Yan y la Ecuación de Advección de Dispersión (EAD). En la regresión no lineal, el modelo de mejor ajuste fue evaluado utilizando seis índices de ajuste, mientras que los parámetros óptimos de los modelos se identificaron por la suma del error normalizado (SNE). La minimización óptima de la distribución del error (DDE), entre valor experimental y modelado, se logró con el índice de ajuste r2 para Thomas no lineal (TNL), mientras la suma del error absoluto (EABS) y la suma del cuadrado del error (ERRSQ), lo hicieron para Yan no lineal (YNL) y la EAD. Existe divergencia en la estimación paramétrica a partir del enfoque de modelación utilizado, derivada de los cambios inducidos en la DDE por la linealización de los modelos. La idoneidad para explicar el proceso de adsorción sigue el orden: TNL>EAD> YNL> Thomas lineal (TL)>Yan lineal (YL). Se puede concluir que la regresión no lineal fue más apropiada para el proceso de estimación paramétrica de los modelos de adsorción.
Determination Of The Implementation Of Financial Reports Based On SAK EMKM
Authors: Ningdiyah Endra Wahyu , Yulianto Mochamad Rizal , Biduri Sarwenda , Prasojo Bayu Hari , Pratiwi Rossy
Published: February 2024

Purpose: This research aims to find Determination of the implementation of financial reports based on SAK EMKM.
Methodology: The sample in this study was 65 Food and Beverage MSMEs in Sidoarjo District using convenience sampling techniques. Tech The data analysis used is analysis multiple linear regression with SPSS 27.
Findings: Based on t test results show that perception MSME actors have no influence to implementation of financial reports based on SAK EMKM, meanwhile socialization of SAK EMKM and levels education owner influential to implementation of financial reports based on SAK EMKM.
Practical implications: The practical implications of this research can be used as a reference in planning and implementing SAK EMKM in MSMEs. MSME players should train their skills in the field of financial accounting, as well as provide supporting facilities to help implement SAK EMKM. Regulators who experience problems in planning and implementing SAK EMKM for MSMEs can consider factors such as performance expectations, expectations of the business world, and supporting facilities.
Originality/value: This research initiates the use of additional indicators from previous research as additional measuring tools in measuring readiness to implement SAK EMKM. This makes the assessment of MSME readiness in implementing SAK EMKM more comprehensive.
Self-Assessment Regime, Tax Compliance, And Tax Administration: Evidence From Emerging Economy
Authors: Madugba Joseph , Egbide Ben-caleb, , Nonye. D Uzoka, , Vivian I. Oparah , Chinagorom Onuoha, , Mmerenini Godwin, , Andrew Agbiogwu, , James Dokia
Published: February 2024

Purpose: This study examined the effect of self-assessment regime and tax compliance on tax administration in Nigeria. The specific objective was to find out the effect fiscal governance quality tax-payers knowledge (TKW), filling of tax returns (FTR), financial constraints (FCT), ability to pay tax without being compelled (PAC).

Methodology/approach: The study adopted the survey research design This is because the objective of the study is to systematically obtain information to describe how self-assessment endues tax compliance and tax administration. The population of this study is the 96 conventional Federal Inland Revenue Tax offices and all corporate taxpayers in Nigeria. The study utilized the purposive sampling technique considering responses from our respondents, fifteen conventional federal inland revenue tax offices and twenty-five corporate taxpayers were chosen for the study. One hundred and two respondents out of which forty-five were from conventional Federal Inland revenue tax office and fifty-seven responses from corporate taxpayers. The source of data is primary and five-point Likert scale questionnaires were designed to generate responses from respondents. Out of a total number of 750 questionnaires sent out through Google, only 252 were returned. The study made use of inferential and descriptive statistics to analyze the responses with the aid of SPSS.

Findings: The finding indicated that there is a significant association between tax knowledge and ability to pay tax without being forced and governance quality, but filling of tax return and financial constraint have negative effect on governance quality. The study concluded that the association between self-assessment regime and tax compliance and tax administration in Nigeria is significant and the study recommended that loopholes from where tax revenue is lost should be covered to increase tax revenue in Nigeria.

Practical Implication:  The research finding has an effect on tax policy makers and taxpayers in Nigeria

Originality/Value: this study is having modified the existing variables used by previous and introduced new ones as it introduced financial constraint and ability to pay tax as a measure of tax compliance.
PENDEKATAN BERBASIS GENOMIK DALAM MENGATASI PERMASALAHAN ABNORMALITAS KLON KELAPA SAWIT
Authors: Nugroho Syarul
Published: February 2024

Peningkatan permintaan minyak sawit dunia sejalan dengan jumlah populasi global yang terus bertambah. Kebutuhan minyak tetap dapat terpenuhi tanpa perlu melakukan perluasan lahan dengan meningkatkan produktivitas kelapa sawit. Perbanyakan klon kelapa sawit secara in vitro diperkirakan menghasilkan minyak 30% lebih banyak dibandingkan kelapa sawit DxP-nya. Klon kelapa sawit memiliki permasalahan yaitu abnormalitas yang menghasilkan buah mantel dengan hasil minyak rendah serta tidak menghasilkan biji. Metilasi pada situs Karma menjadi penyebab abnormalitas pada klon kelapa sawit. Pendekatan berbasis genomik menjadi solusi untuk mengatasi fenomena abnormalitas klon. Pendekatan genomik yang ditawarkan antara lain pencarian marka molekuler dan pengaplikasian CRISPR/dCas9. Marka molekuler yang diperoleh dapat digunakan dalam deteksi dini abnormalitas klon kelapa sawit. CRISPR/dCas9 dapat dikembangkan untuk memicu metilasi spesifik di situs Karma untuk mendapatkan klon kelapa sawit normal. Terlepas dari tantangannya, kemajuan teknologi genomik menawarkan potensi keberhasilan dalam mengatasi permasalahan abnormalitas klon kelapa sawit.
The Validity of Computed Tomography Guided Lung Tru- cut Biopsies in Achieving Accurate Tissue Results
Authors: Khashman Basim Mohammed , Mohson Khaleel I , Abdul Qader Omar Abdul Jabbar , Abdul Ghafour Kifah H.
Published: February 2024

Objective: This study aims to assess the efficacy of CT-guided true-cut biopsy as a less invasive and cost-effective diagnostic technique for peripherally placed lung lesions.

 

Methods: fourty patients with solitary lung nodule were involved in this study, true cut biopsies under Ct guide was taken then processed for routine H&E staining.

 

Results: different pathological features can be identified with different pathological features giving primary diagnostic screening for lung cancer

 

Conclusion: CT guided thoracic lesion biopsy is very efficient, cost-effective and less invasive technique when compared with the thoracic surgery
Unveiling the Mediating Role of the REJ Region: PC1 and Extracellular Matrix Dynamics in ADPKD
Authors: Alrashidi Aljazi Abdullah , Sonbol Hala Salim
Published: February 2024

Objective: This study aimed to investigate the interactions of PC1 with extracellular matrix proteins (ECM) to gain insights into its role in ADPKD onset. This exploration objective is to unravel the significance of these interactions in both the healthy development of kidneys and the underlying mechanisms of ADPKD, potentially identifying therapeutic targets.

Methods: We cloned and expressed the receptor of the egg jelly (REJ) domain as a maltose-binding protein-fusion protein (PET21-MBP(TEV)-REJ). Subsequently, we utilized this construct in a pulldown assay involving HEK 293 cells. In vitro, pull-down assays were conducted to evaluate the binding of the REJ fusion to various ECM components.

Results: The REJ fusion protein effectively binds to vitronectin, Fibulin-1, and actin filament-associated protein (AFAP) 1. These findings indicate that the REJ region acts as a mediator for the interaction between polycystin-1 and the ECM, shedding light on the functional role of polycystin-1 in both cell-matrix and cell-cell interactions.

Conclusion: The detailed characterization of REJ-ECM interactions offers a valuable foundation for future research aimed at systematically studying the effects of disease-causing mutations within the REJ module of human PC-1.
Brand reputation as a critical success factor on the subscription-based gaming market – research results
Authors:   Department of Consumer Research, University of Economics in Katowice, Katowice, Polska, Ryczko Aleksandra
Published: February 2024

Abstract: This study aims to establish the role of a brand reputation as a critical success factor. Although there are studies on brand reputation, none of them focuses on the topic in the context of the subscription-based gaming market. The aim of the study is to esta- blish how opinions of gamers about a game subscription provider and its performance (i.e. brand reputation) impact the success of this brand. An online survey was used as a method. All the findings reveal that the brand with a positive reputation is more suc- cessful than the brand with a negative or less positive reputation. Therefore, it may be stated that the positive reputation of a brand providing a video game subscription service supports the success of this service, while the negative reputation may contribute to its failure. Keywords: brand reputation, video games, subscription services. JEL Classification: M21, M31
In Dubio Pro Natura: in Doubt, should the Environment Be a Priority? A Discourse of Environmental Justice in Indonesia
Authors: Arifin Ridwan , Idris Siti Hafsyah
Published: February 2024

This study explores the critical question of whether the environment should be prioritized in situations of uncertainty, encapsulated by the Latin phrase “In Dubio Pro Natura” (In Doubt, For Nature). Focusing on the context of Indonesia, the discourse navigates the complex terrain of environmental justice. The study delves into the multifaceted challenges faced by Indonesia, considering economic development, social equity, and ecological sustainability. By examining cases of environmental degradation, resource exploitation, and their societal implications, the study aims to shed light on the ethical dimensions of decision-making in the face of environmental uncertainties. Drawing on diverse perspectives, including indigenous knowledge and international frameworks, the discourse advocates for a nuanced approach that balances economic growth with environmental stewardship and social justice. Ultimately, this study outlines the necessity of reevaluating priorities, fostering sustainable practices, and ensuring equitable environmental policies for the well-being of present and future generations in Indonesia.
A importância do benefício assistencial LOAS-BPC
Authors:   , Coutinho Francini Victoria
Published: February 2024

A sociedade se demonstra severa com aqueles que não se mostram com condições de prover sua própria subsistência. Quando tratamos do Benefício de Prestação Continuada (BPC) assegurado pela Lei Orgânica da Previdência Social (LOAS), sabe-se que muitas vezes as pessoas passam grande parte de sua vida sem ter as condições mínimas a direitos fundamentais. Ocorre, no entanto, que muitos deles, senão quase a sua totalidade, acabam por buscar assistência governamental, quando tem assegurado o pagamento de um benefício, desde que preenchidos os requisitos legais para sua concessão. No desenvolvimento do presente trabalho serão abordados os requisitos para a concessão do benefício, as causas características de modo a contribuir para a reinserção social do indivíduo bem como para sua sociabilização.
A responsabilidade civil das agências de turismo como fornecedores de serviços turísticos sob a ótica do código de defesa do consumidor: uma análise jurídica
Authors:   , Cristo Nicole Veiga
Published: February 2024

A responsabilidade civil solidária é um tema muito importante no setor do turismo, visto que envolve a segurança e a qualidade dos serviços prestados aos consumidores. O Código de Defesa do Consumidor estabelece que as agências de turismo são solidariamente responsáveis pelos serviços prestados pelas operadoras de turismo, e companhias aéreas, garantindo assim a segurança e qualidade dos serviços contratados. Porém, recentemente houve um novo entendimento no que diz respeito a não responsabilidade solidária entre as agências de turismo e as companhias aéreas. Em decisão inédita, o Superior Tribunal de Justiça (STJ) decidiu que as agências de turismo não tem responsabilidade solidária sobre os serviços prestados pelas companhias aéreas, visto que não há relação de subordinação ou de dependência entre elas. Essa decisão é um marco importante no setor do turismo, pois altera o entendimento que vinha sendo adotado até então. Agora, as agências de turismo ficam isentas de responsabilidade em casos envolvendo atrasos, cancelamentos e outras questões relacionadas aos voos contratados pelos consumidores através das agências de turismo. Por fim, a responsabilidade civil solidária é um tema crucial no turismo, e deve ser levado em consideração tanto pelas agências de turismo quanto pelas operadoras de turismo e companhias aéreas. A recente decisão do STJ traz um novo entendimento sobre a não responsabilidade solidária entre as agências de turismo e as companhias aéreas, garantindo assim uma distribuição mais clara das responsabilidades e maior segurança jurídica para todos os envolvidos no setor.
Ação civil pública e estatuto da criança e do adolescente: uma práxis dualista para garantia e defesa dos direitos difusos e coletivos
Authors:   , Barbosa Gabriel Pedroso
Published: February 2024

A desigualdade social no Brasil afeta a todos e principalmente os hipossuficientes. Neste estamento impera a incerteza econômica que impacta a todos e de forma mais intensa, os menores. O Estatuto da Criança e do Adolescente visa garantir direitos e proteger os menores das situações de risco, violação de direitos e criminalidade. Está disposto entre os direitos de interesse difuso e coletivo, categoria de direito, difundida no Brasil a partir da década de 1980 justamente para tratar de questões especificas e não tratadas no ordenamento jurídico. Para tratar dos interesses difusos dos menores o Estatuto da Criança e do Adolescente definiu a prerrogativa do Ministério Público para propor ação civil pública – instituto de defesa coletiva de interesses difusos disposto na Lei de Ação Civil Pública - para a defesa do melhor interesse da criança e do adolescente.
Alienação parental e suas consequências jurídicas
Authors:   , Cassão Ana Beatriz Bernal
Published: February 2024

O presente artigo tem o objetivo de analisar o fenômeno da alienação parental mediante compilação bibliográfica através de revisão de literatura. Foram abordados a definição de alienação parental e síndrome da alienação parental, assim como o princípio da dignidade da pessoa humana, o melhor interesse da criança e do adolescente, o fenômeno das falsas memórias e falsas denúncias, além da definição de guarda unilateral e guarda compartilhada. Foram utilizados como base para o artigo: a Constituição Federal (1988), o Estatuto da Criança e do Adolescente (1990), a Lei de Alienação Parental (Lei nº 12.318/2010), além da revisão bibliográfica de diversos autores, como Richard Gardner, Paulo Lôbo, Ana Carolina Madaleno e Rolf Madaleno, entre outros. Por fim, foi possível chegar-se à conclusão de que a guarda compartilhada é uma possível forma de mitigação do fenômeno da alienação parental.
Poziom przygotowania zawodowego rolników - członków grup producenckich
Authors: Parzonko Anna
Published: February 2024

O doświadczeniu zawodowym rolników w efektywnym prowadzeniu gospodarstw rolnych decydują dwa istotne czynniki, a mianowicie poziom i specjalizacja ich wykształcenia oraz uczestnictwo w szkoleniach i kursach aktualizujących i doskonalących ich wiedzę rolniczą. W artykule przedstawiono ocenę poziomu przygotowania zawodowego członków grup producenckich. W analizie przyjęto następujące kryteria: poziom wykształcenia badanej populacji, zgodność wykształcenia rolnika z charakterem pracy w gospodarstwie rolnym oraz udział w szkoleniach organizowanych przez ośrodki doradztwa rolniczego.
Opłacalność i ryzyko inwestycji w papiery wartościowe na przykładzie wybranego portfela
Authors: Krawczyk Ewa
Published: February 2024

Rozważając inwestycję w aktywa finansowe, można brać pod uwagę dwie możliwości: powierzenie pieniędzy funduszom inwestycyjnym lub zbudowanie indywidualnego portfela papierów wartościowych. W związku z dobrymi wynikami regulowanych rynków giełdowych zbudowano portfel zapobiegawczy. W jego skład wchodzą instrumenty dłużne i akcje notowane na giełdzie. Akcje stanowiły 40 proc., depozyty bankowe 19 proc., a obligacje - odpowiednio 41 proc. Następnie Autorka zbadała ryzyko oraz efektywną i oczekiwaną stopę zwrotu z tego portfela. Wykorzystując dwuczynnikowy model Sharpe’a do analizy problemu portfelowego, zbudowano efektywny portfel akcji. Zmieniła się jego struktura w stosunku do portfela ostrożnościowego. Zastosowane podejście pozwoliło obniżyć ryzyko z 17,72 proc. do 13,29 proc. i zwiększyć zwrot z inwestycji z 9,83 proc. do 10,40 proc.
Współczesne problemy funkcjonowania demokracji, ich rozwiązywanie
Authors: Błaszczyk Andrzej
Published: February 2024

Autor opisuje zmieniające się systemy demokracji w rozwijającym się świecie. Zwraca uwagę na kryzys obecnych mechanizmów demokracji i jego przyczyny. Zauważa, że w debacie o przyszłości należy brać pod uwagę nowe parametry współczesnego życia. W konkluzji autor stwierdza, że budowanie nowych mechanizmów demokracji przywróci jej atrakcyjność.
Kształtowanie struktury kapitału w opinii przedsiębiorców
Authors: Franc Justyna
Published: February 2024

W artykule przedstawiono opinie na temat różnych aspektów zarządzania strukturą kapitału, które przedstawili dyrektorzy tych przedsiębiorstw rolnych, które zostały zidentyfikowane jako odnotowujące sukces (7 firm) lub porażkę (2 firmy). Wyniki badania wskazują, że teorie Modiglianiego i Millera znalazły potwierdzenie w działalności gospodarczej.
Powstanie i przemiany w funkcjonowaniu Zakładów Mięsnych "Wierzejki" w latach 1991-2002
Authors: Cała Elżbieta
Published: February 2024

W artykule przedstawiono kierunki rozwoju Zakładów Mięsnych „Wierzejki”. Omówiono tendencje w zakresie zatrudnienia, majątku i produkcji. Do przeprowadzenia analizy finansowej wykorzystano roczne sprawozdania finansowe za lata 1997-2002. Wyniki wskazują, że dane przedsiębiorstwo dokonało znacznych inwestycji. Działalność biznesowa Zakładów „Wierzejki” opierała się na solidnej znajomości rynku oraz dywersyfikacji produktów i usług. „Wierzejki” dostosowały swoją działalność w zakresie przetwórstwa i sprzedaży mięsa zarówno do nowych warunków rynkowych, jak i standardów prawnych. Przyjęta strategia pozwoliła przedsiębiorstwu osiągnąć przewagę konkurencyjną na lokalnych rynkach mięsa.
Accuracy and Feasibility of Real-time Continuous Glucose Monitoring in Critically Ill Patients After Abdominal Surgery and Solid Organ Transplantation
Authors: Voglová Hagerf Barbora , Protus Marek , Nemetova Lenka , Mraz Milos , Kieslichova Eva , Uchytilova Eva , Indrova Veronika , Lelito Jan , Girman Peter , Haluzík Martin , Franekova Janka , Svirlochova Veronika , Klonoff David C. , Kohn Michael A. , Jabor Antonin
Published: February 2024

OBJECTIVE

Glycemia management in critical care is posing a challenge in frequent measuring and adequate insulin dose adjustment. In recent years, continuous glucose measurement has gained accuracy and reliability in outpatient and inpatient settings. The aim of this study was to assess the feasibility and accuracy of real-time continuous glucose monitoring (CGM) in ICU patients after major abdominal surgery.

RESEARCH DESIGN AND METHODS

We included patients undergoing pancreatic surgery and solid organ transplantation (liver, pancreas, islets of Langerhans, kidney) requiring an ICU stay after surgery. We used a Dexcom G6 sensor, placed in the infraclavicular region, for real-time CGM. Arterial blood glucose measured by the amperometric principle (ABL 800; Radiometer, Copenhagen, Denmark) served as a reference value and for calibration. Blood glucose was also routinely monitored by a StatStrip bedside glucose meter. Sensor accuracy was assessed by mean absolute relative difference (MARD), bias, modified Bland-Altman plot, and surveillance error grid for paired samples of glucose values from CGM and acid-base analyzer (ABL).

RESULTS

We analyzed data from 61 patients and obtained 1,546 paired glucose values from CGM and ABL. Active sensor use was 95.1%. MARD was 9.4%, relative bias was 1.4%, and 92.8% of values fell in zone A, 6.1% fell in zone B, and 1.2% fell in zone C of the surveillance error grid. Median time in range was 78%, with minimum (<1%) time spent in hypoglycemia. StatStrip glucose meter MARD compared with ABL was 5.8%.

CONCLUSIONS

Our study shows clinically applicable accuracy and reliability of Dexcom G6 CGM in postoperative ICU patients and a feasible alternative sensor placement site.