bluuebunny/crossref_metadata_2025 huggingface dataset:
Prevalence of Prehypertension and Associated Cardiovascular Risk Profiles among Adults in Peru: Findings from a Nationwide Population-Based Study
Authors: Hernández-Vásquez Akram , Vargas-Fernández Rodrigo
Published: June 2022

Prehypertension is a clinical condition that increases the risk of hypertension and cardiovascular disease. In South American countries, prehypertension affects almost one-third of the population. The aim of the present study was to determine the association between prehypertension and the main cardiometabolic risk factors according to the US National Cholesterol Education Program Adult Treatment Panel III by sex in the Peruvian population. A total of 863 participants surveyed were included in the study. A total of 21.1% had prehypertension, 14.4% of whom were female, and 30.5% were male. Women belonging to the age group 50–59 years, having abdominal obesity and being a current smoker, were more likely to have prehypertension, while the likelihood of having prehypertension increased in men with abdominal obesity. Three out of 10 men and one out of 10 women in Peru have prehypertension. In women, being 50 to 59 years of age, having abdominal obesity, and being a current smoker, increased the probability of having prehypertension, whereas, in men, only abdominal obesity was found to be associated with prehypertension. Our findings will allow the development of prevention strategies focused on the appropriate diagnosis of prehypertension and cardiometabolic risk factors according to sex.
Physical Fitness of Chinese Primary School Students across the Coronavirus (COVID-19) Outbreak: A Retrospective Repeated Cross-Sectional Study
Authors: Hu Wei-Ning , Li Dong-Yue , Lam Wing-Kai , Wang Yi , Wong Duo Wai-Chi , Cheung James Chung-Wai
Published: June 2022

Social distancing measures against COVID-19 imposed restrictions on students that may have affected their physical health and fitness. The objective of this study was to investigate the change in physical fitness of primary school students across the coronavirus outbreaks from 2019 to 2021. This was a retrospective repeated cross-sectional study. We obtained the annual physical and fitness assessment data measured every November for all students at the same primary school in Guangzhou, China. There was a total of 6371 observations in the dataset for three years. The physical fitness of the students was evaluated with an overall physical fitness score, body mass index (BMI), lung vital capacity, physical flexibility (via a sit-and-reach test) and sports task performances (sprint, shuttle run, rope-jumping, and sit-up). Generalised estimating equations were used to determine any significant changes from 2019 to 2021, adjusted for confounders. After the COVID-19 outbreak in 2021, there was a significant elevation in BMI of 0.64 kg/m2 in 2020 and 0.39 kg/m2 in 2021 (p < 0.001). The overall physical fitness score was significantly increased by 2.1 and 4.1 points, respectively, in 2020 and 2021 (p < 0.001). Lung vital capacity and rope-jumping performance were significantly improved in both 2020 and 2021 compared with 2019, and sit-up performance was marginally significantly improved in 2020 and significantly improved in 2021. However, students demonstrated poorer flexibility and sprint and shuttle run performance in 2021 compared with 2019. A health promotion programme during and after COVID-19, including online physical education classes, television broadcasts, and a rope-jumping campaign, could account for these positive outcomes, along with the ease of administering rope-jumping and sit-ups at home.
Multiobjective Emergency Resource Allocation under the Natural Disaster Chain with Path Planning
Authors: Wang Feiyue , Xie Ziling , Liu Hui , Pei Zhongwei , Liu Dingli
Published: June 2022

Public safety and health cannot be secured without the comprehensive recognition of characteristics and reliable emergency response schemes under the disaster chain. Distinct from emergency resource allocation that focuses primarily on a single disaster, dynamic response, periodic supply, and assisted decision-making are necessary. Therefore, we propose a multiobjective emergency resource allocation model considering uncertainty under the natural disaster chain. Resource allocation was creatively combined with path planning through the proposed multiobjective cellular genetic algorithm (MOCGA) and the improved A* algorithm with avoidance of unexpected road elements. Furthermore, timeliness, efficiency, and fairness in actual rescue were optimized by MOCGA. The visualization of emergency trips and intelligent avoidance of risk areas were achieved by the improved A* algorithm. The effects of logistics performance, coupling of disaster factors, and government regulation on emergency resource allocation were discussed based on different disaster chain scenarios. The results show that disruption in infrastructure support, cascading effect of disasters, and time urgency are additional environmental challenges. The proposed model and algorithm work in obtaining the optimal solution for potential regional coordination and resilient supply, with a 22.2% increase in the total supply rate. Cooperative allocation complemented by political regulation can be a positive action for successfully responding to disaster chains.
The Intensity of the Health Behaviors of People Who Practice Wheelchair Basketball, Wheelchair Rugby and Para-Rowing
Authors: Nowak Maria Alicja , Kolbowicz Marek , Kuska Michalina , Sygit Katarzyna , Sygit Marian , Nowak Leonard , Kotarska Katarzyna
Published: June 2022

Sports serve people with disabilities as a form of rehabilitation. Sporting activity is a health-promoting behavior choice and a chance to achieve the best possible sports results. The aim of this study was to evaluate the intensity of health behaviors in people practicing wheelchair basketball, wheelchair rugby and para-rowing. The study encompassed 176 athletes with disabilities, aged 19 to 49 (mean age 34.41 ± 8.56), from all over Poland. Men accounted for 83.5% of the respondents. They all had a significant degree of disability and used wheelchairs in their daily lives. The authors used Juczyński’s Health Behavior Inventory (HBI) and the authors’ own survey questionnaire. Nonparametric tests were used. A greater intensity of health behaviors in general (HBI—point score) and in four categories (correct eating habits—CEH, preventive behaviors—PB, positive mental attitude—PMA, health practices—HP) was observed in rugby and basketball players (compared with para-rowers). Disabled rowers achieved the poorest results. Polish Champions scored better results in preventive behaviors (PB) and weaker results in positive mental attitude (PMA)compared with those practicing amateur sport. Respondents who trained every day and had the longest weekly exercise time (>360 min) achieved the highest results in HBI in general and in all categories compared with those who trained once a week for less than 120 min a week. Respondents with higher education, those in a better financial situation, those who were employed and married, and those who were rural residents displayed a greater intensity of health-related behaviors. People in a more difficult financial situation, who had less education, who were cohabiting, and who lived on only a pension presented more preventive behaviors. There is a need for systemic health education aimed at people with disabilities who practice various sports disciplines.
How Effective Is a Traffic Control Policy in Blocking the Spread of COVID-19? A Case Study of Changsha, China
Authors: Xiang Wang , Chen Li , Peng Qunjie , Wang Bing , Liu Xiaobing
Published: June 2022

(1) Background: COVID-19 is still affecting people’s daily lives. In the past two years of epidemic control, a traffic control policy has been an important way to block the spread of the epidemic. (2) Objectives: To delve into the blocking effects of different traffic control policies on COVID-19 transmission. (3) Methods: Based on the classical SIR model, this paper designs and improves the coefficient of the infectious rate, and it builds a quantitative SEIR model that considers the infectivity of the exposed for traffic control policies. Taking Changsha, a typical city of epidemic prevention and control, as a study case, this paper simulates the epidemic trends under three traffic control policies adopted in Changsha: home quarantine, road traffic control, and public transport suspension. Meanwhile, to explore the time sensitivity of all traffic control policies, this paper sets four distinct scenarios where the traffic control policies were implemented at the first medical case, delayed by 3, 5, and 7 days, respectively. (4) Results: The implementation of the traffic control policies has decreased the peak value of the population of the infective in Changsha by 66.03%, and it has delayed the peak period by 58 days; with the home-quarantine policy, the road traffic control policy, and the public transport suspension policy decreasing the peak value of the population of the infective by 56.81%, 39.72%, and 45.31% and delaying the peak period by 31, 18, and 21 days, respectively; in the four scenarios where the traffic control policies had been implemented at the first medical case, delayed by 3, 5, and 7 days, respectively, the variations of both the peak value and the peak period timespan of confirmed cases under the home-quarantine policy would have been greater than under the road traffic control and the public transport suspension policies. (5) Conclusions: The implementation of traffic control policies is significantly effective in blocking the epidemic across the city of Changsha. The home-quarantine policy has the highest time sensitivity: the earlier this policy is implemented, the more significant its blocking effect on the spread of the epidemic.
Risky Play and Social Behaviors among Japanese Preschoolers: Direct Observation Method
Authors: Imai Natsuko , Shikano Akiko , Kidokoro Tetsuhiro , Noi Shingo
Published: June 2022

While limited evidence is available, preliminary studies highlight the potential health benefits of risky play. However, most of the studies have used subjective methods (i.e., questionnaires) to evaluate children’s risky play, which limits their validity and reliability. The purpose of the present study was to examine the relationship between the frequency of risky play and social behavior among Japanese preschoolers by using a valid and reliable method such as direct observation. A total of 32 Japanese preschoolers (71.4 ± 3.5 months old) participated in the study, and their social behaviors were measured by the Strength and Difficulties Questionnaire (SDQ). Data regarding the frequency of risky play was collected through direct observation. Results stated that, in a non-adjusted model, there was no significant association between children’s risky play and prosocial behavior. However, the association became significant after adjusting for covariates such as gender, parental employment status, and physical activity. In contrast, there was no significant association between children’s risky play and problem behavior (hyperactivity and aggression) after adjusting for covariates. In conclusion, covariates such as parental employment should be considered when examining the benefits of risky play.
Cross-Cultural Translation and Application of the Lieberman–Brian Inclusion Rating Scale for PE in German-Speaking Countries
Authors: Giese Martin , Grenier Michelle , Lieberman Lauren J. , Meier Stefan
Published: June 2022

Overcoming participation barriers of students with disabilities in physical education is of great importance and an internationally recognized goal. Research highlights that students with disabilities have mixed feelings about their inclusion experiences in physical education. Physical education teachers often do not feel prepared to appropriately support all students. In German-speaking countries in particular, there is a strong tradition of segregation, with varying interpretations of inclusion. In this light, an instrument to reliably assess the inclusive potential of physical education is needed, thereby providing data on the efficacy of teachers’ practices. Such an assessment scale would be important to identify barriers to inclusive physical education while providing teachers with data that could potentially enhance the learning environment. The purpose of this study was to outline initial insights into the cross-cultural translation process of the Lieberman/Brian Inclusion Rating Scale for PE in German-speaking countries. The translation process followed suggestions for transcultural validation. Expert review was provided to check content and face validity. Major item challenges centered around paraeducators, gym management, and conceptual differences regarding physical education.
Psychiatric and Psychosocial Factors of Suicide Decedents and Survivor of Suicide Loss: Psychological Autopsy Study of Incheon City in South Korea
Authors: Bae Mi-Nam , Cho Seo-Eun , Ryu Ju-Hyeon , Kim Mi-Hwa , Jeon Hye-Jin , Shin Eun-Ji , Lee Seon-A , Hwang Tae-Yeon , Kang Seung-Gul
Published: June 2022

In South Korea, the suicide rate is more than double the OECD average, and precise identification of the cause is required for suicide prevention. Psychological autopsy is used to reveal factors related to suicidal behavior; however, such studies are lacking in Korea. This study investigated the factors related to suicide using psychological autopsies in Incheon, a major city in Korea. In total, 46 cases were investigated using the Korea-Psychological Autopsy Checklist (K-PAC), and data on mental health conditions and psychosocial factors of suicide decedents and their families were analyzed. It was estimated that 87% of individuals of suicides had a mental health condition before death, but only 15.2% continued treatment or counseling. Most individuals who died of suicide showed warning signs before death, but only 19.6% of survivors of suicide loss noticed them. Mental health concerns before and after the death of the individual were also identified in more than half of their families. To prevent suicide, intensive and continuous treatment for psychiatric conditions and prompt recognition of active response to suicide warning signs are required. Care for the mental health of family members is also important.
Cucurbitacin B Down-Regulates TNF Receptor 1 Expression and Inhibits the TNF-α-Dependent Nuclear Factor κB Signaling Pathway in Human Lung Adenocarcinoma A549 Cells
Authors: Kusagawa Eiichi , Okuda Chiharu , Yamaguchi Rikako , Nakano Kaori , Miyake Yasunobu , Kataoka Takao
Published: June 2022

Pro-inflammatory cytokines, such as tumor necrosis factor-α (TNF-α), induce the expression of intracellular adhesion molecule-1 (ICAM-1) by activating the nuclear factor κB (NF-κB) signaling pathway. In the present study, we found that cucurbitacin B decreased the expression of ICAM-1 in human lung adenocarcinoma A549 cells stimulated with TNF-α or interleukin-1α. We further investigated the mechanisms by which cucurbitacin B down-regulates TNF-α-induced ICAM-1 expression. Cucurbitacin B inhibited the nuclear translocation of the NF-κB subunit RelA and the phosphorylation of IκBα in A549 cells stimulated with TNF-α. Cucurbitacin B selectively down-regulated the expression of TNF receptor 1 (TNF-R1) without affecting three adaptor proteins (i.e., TRADD, RIPK1, and TRAF2). The TNF-α-converting enzyme inhibitor suppressed the down-regulation of TNF-R1 expression by cucurbitacin B. Glutathione, N-acetyl-L-cysteine, and, to a lesser extent, L-cysteine attenuated the inhibitory effects of cucurbitacin B on the TNF-α-induced expression of ICAM-1, suggesting that an α,β-unsaturated carbonyl moiety is essential for anti-inflammatory activity. The present results revealed that cucurbitacin B down-regulated the expression of TNF-R1 at the initial step in the TNF-α-dependent NF-κB signaling pathway.
Cisplatin-Resistant CD44+ Lung Cancer Cells Are Sensitive to Auger Electrons
Authors: Madsen Karina Lindbøg , Gerke Oke , Høilund-Carlsen Poul F. , Olsen Birgitte Brinkmann
Published: June 2022

Cancer stem cells (CSCs) are resistant to conventional therapy and present a major clinical challenge since they are responsible for the relapse of many cancers, including non-small cell lung cancer (NSCLC). Hence, future successful therapy should also eradicate CSCs. Auger electrons have demonstrated promising therapeutic potential and can induce DNA damage while sparing surrounding cells. Here, we sort primary patient-derived NSCLC cells based on their expression of the CSC-marker CD44 and investigate the effects of cisplatin and a thymidine analog (deoxyuridine) labeled with an Auger electron emitter (125I). We show that the CD44+ populations are more resistant to cisplatin than the CD44− populations. Interestingly, incubation with the thymidine analog 5-[125I]iodo-2′-deoxyuridine ([125I]I-UdR) induces equal DNA damage, G2/M cell cycle arrest, and apoptosis in the CD44− and CD44+ populations. Our results suggest that Auger electron emitters can also eradicate resistant lung cancer CD44+ populations.
Electrospun Membranes Designed for Burst Release of New Gold-Complexes Inducing Apoptosis of Melanoma Cells
Authors: Guadagno Liberata , Raimondo Marialuigia , Vertuccio Luigi , Lamparelli Erwin Pavel , Ciardulli Maria Camilla , Longo Pasquale , Mariconda Annaluisa , Della Porta Giovanna , Longo Raffaele
Published: June 2022

Two non-commercial metallic Au-based complexes were tested against one of the most aggressive malignant melanomas of the skin (MeWo cells), through cell viability and time-lapse live-cell imaging system assays. The tests with the complexes were carried out both in the form of free metallic complexes, directly in contact with the MeWo cell line culture, and embedded in fibers of Polycaprolactone (PCL) membranes produced by the electrospinning technique. Membranes functionalized with complexes were prepared to evaluate the efficiency of the membranes against the melanoma cells and therefore their feasibility in the application as an antitumoral patch for topical use. Both series of tests highlighted a very effective antitumoral activity, manifesting a very relevant cell viability inhibition after both 24 h and 48 h. In the case of the AuM1 complex at the concentration of 20 mM, melanoma cells completely died in this short period of time. A mortality of around 70% was detected from the tests performed using the membranes functionalized with AuM1 complex at a very low concentration (3 wt.%), even after 24 h of the contact period. The synthesized complexes also manifest high selectivity with respect to the MeWo cells. The peculiar structural and morphological organization of the nanofibers constituting the membranes allows for a very effective antitumoral activity in the first 3 h of treatment. Experimental points of the release profiles were perfectly fitted with theoretical curves, which easily allow interpretation of the kinetic phenomena occurring in the release of the synthesized complexes in the chosen medium.
A New Sternorrhynchan Genus and Species from the Triassic Period of China That Is Likely Related to Protopsyllidioid (Insecta, Hemiptera)
Authors: Huang Diying , Hakim Marina , Fu Yanzhe , Nel André
Published: June 2022

Triassopsyllidiida pectinata gen. et sp. nov. is described from the latest Middle Triassic Tongchuan biota of China and tentatively attributed to the superfamily Protopsyllidioidea. Its forewing venation is unique among this superfamily in the anteriorly pectinate vein ScP + RA and the presence of a veinlet between R and M + CuA. Its exact position in this group remains uncertain, mainly because of the weak diagnostic value of the wing venation characters in these insects. The phylogenetic relationships of the Protopsyllidioidea are discussed.
Synthesis and Ring-Chain Tautomerism of 1-(4-Ethoxyphenyl)-5-formyl-1H-1,2,3-triazole-4-carboxylic Acid: The First Representative of a 5-Formyl-1H-1,2,3-triazole-4-carboxylic Acids Series
Authors: Pokhodylo Nazariy T. , Obushak Mykola D.
Published: June 2022

Synthesis of the first representative of a 5-formyl-1H-1,2,3-triazole-4-carboxylic acids series – 1-(4-ethoxyphenyl)-5-formyl-1H-1,2,3-triazole-4-carboxylic acid was performed. The 1-azido-4-ethoxybenzene was chosen as a starting reagent in a two-step synthesis, which reacted with the ethyl 4,4-diethoxy-3-oxobutanoate under base catalysis to form ethyl 5-(diethoxymethyl)-1-(4-ethoxyphenyl)-1H-1,2,3-triazole-4-carboxylate with protected formyl and acid groups. By the subsequent saponification of the ester group and removing of acetal protection, the target 1-(4-ethoxyphenyl)-5-formyl-1H-1,2,3-triazole-4-carboxylic acid was obtained. It has been found that the free acid form predominated in the solution under its cyclic 6-hydroxy-1,6-dihydro-4H-furo[3,4-d][1,2,3]triazol-4-one tautomer. According to 1H NMR, cyclic hemiacetal is about 20%.
Novel Surfactant-Induced MWCNTs/PDMS-Based Nanocomposites for Tactile Sensing Applications
Authors: Nag Anindya , Afsarimanesh Nasrin , Nuthalapati Suresh , Altinsoy Mehmet Ercan
Published: June 2022

The paper presents the use of surfactant-induced MWCNTs/PDMS-based nanocomposites for tactile sensing applications. The significance of nanocomposites-based sensors has constantly been growing due to their enhanced electromechanical characteristics. As a result of the simplified customization for their target applications, research is ongoing to determine the quality and quantity of the precursor materials that are involved in the fabrication of nanocomposites. Although a significant amount of work has been done to develop a wide range of nanocomposite-based prototypes, they still require optimization when mixed with polydimethylsiloxane (PDMS) matrices. Multi-Walled Carbon Nanotubes (MWCNTs) are one of the pioneering materials used in multifunctional sensing applications due to their high yield, excellent electrical conductivity and mechanical properties, and high structural integrity. Among the other carbon allotropes used to form nanocomposites, MWCNTs have been widely studied due to their enhanced bonding with the polymer matrix, highly densified sampling, and even surfacing throughout the composites. This paper highlights the development, characterization and implementation of surfactant-added MWCNTs/PDMS-based nanocomposites. The prototypes consisted of an optimized amount of sodium dodecyl sulfonate (SDS) and MWCNTs mixed as nanofillers in the PDMS matrix. The results have been promising in terms of their mechanical behaviour as they responded well to a maximum strain of 40%. Stable and repeatable output was obtained with a response time of 1 millisecond. The Young’s Modulus of the sensors was 2.06 MPa. The utilization of the prototypes for low-pressure tactile sensing applications is also shown here.
High-Temperature Tribological Behavior of HDPE Composites Reinforced by Short Carbon Fiber under Water-Lubricated Conditions
Authors: Zhong Wen , Chen Siqiang , Tong Zhe
Published: June 2022

The polymer water-lubricated bearing is widely used in marine transmission systems, and the tribological properties can be improved by addition of inorganic nano-fillers. The aim of this study is to investigate the effect of SCFs and temperature on the water-lubricating properties of high-density polyethylene (HDPE) composites. HDPE composites reinforced by varying content of short carbon fibers (SCFs) were fabricated via twin-screw extrusion and injection molding techniques to study the hardness and surface wettability of those composites. The tribological properties under water-lubricated conditions were investigated through a pin-on-disk reciprocating tribometer under different temperatures. The results showed that the increase in hardness of HDPE composites reached maximum to 42.9% after adding 25 wt % SCFs. The contact angle also increased with the increase in SCFs content and reached a maximum of 95.2° as the amount of SCFs increased to 20 wt %. The incorporation of SCFs increased the wear resistance and lubricating property of HDPE composites at different temperatures. The HDPE composite containing 20 wt % SCFs showed the lowest friction coefficient of 0.076 at 40 °C, and the wear track depth reached a maximum of 36.3 mm at 60 °C. Based on the surface wetting property and wear analysis, potential effect mechanisms of fillers and temperature were discussed. The knowledge from this study is useful for designing the anti-wear water-lubricated polymer bearing.
Drop–Dry Deposition of Ni(OH)2 Precursors for Fabrication of NiO Thin Films
Authors: Li Tong , Okada Tetsuya , Ichimura Masaya
Published: June 2022

Drop–dry deposition (DDD) is a method of depositing thin films by heating and drying the deposition solution dropped on a substrate. We prepared Ni(OH)2 precursor thin films by DDD and annealed them in air to prepare NiO thin films. The appropriate deposition conditions were found by changing the number of drop–dry cycles and the concentrations of chemicals in the solution, and the Ni(OH)2 precursor film with a thickness of 0.3 μm and optical transmittance of more than 95% was successfully deposited. Raman and X-ray diffraction measurements were performed, and it was found that the NiO film was successfully fabricated after annealing at 400 °C. The p-type conductivity of the annealed film was confirmed by photoelectrochemical measurements. In addition, we prepared n-type ZnO by electrochemical deposition on NiO thin films. The current–voltage measurement results show that the ZnO/NiO heterojunction had rectification properties.
A Comparative Study to Evaluate the Essential Work of Fracture to Measure the Fracture Toughness of Quasi-Brittle Material
Authors: Abdellah Mohammed Y. , Zuwawi Abdul-Rahman , Azam Sufyan A. , Hassan Mohamed K.
Published: June 2022

In the present work, three different woven composite laminates were fabricated using the hand lay-up method. The woven reinforcement fibres were carbon fibres (CFRP), glass fibres (GFRP-W) and (GFRP-R) in combination with epoxy resin. Then, the central notch specimen tensile test (CNT) was used to measure the fracture toughness and the corresponding surface release energy (GIC). Then, the data were compared with the essential work of fracture (we) values based on the stored energy of the body to obtain a new standard fracture toughness test for composite laminates using relatively simple techniques. In addition to an extended finite element model, XFEM was implemented over a central notch specimen geometry to obtain a satisfactory validation of the essential work of fracture concepts. Therefore, the average values of (GIC) were measured with CNT specimens 25.15 kJ/m2, 32.5 kJ/m2 and 20.22 kJ/m2 for CFRP, GFRP-W and GFRP-R, respectively. The data are very close as the percentage error for the surface release energy measured by the two methods was 0.83, 4.6 and 5.16 for carbon, glass and random fibre composite laminates, respectively. The data for the fracture toughness of XFEM are also very close. The percentage error is 4.6, 5.25 and 2.95 for carbon, glass and random fibre composite laminates, respectively. Therefore, the fundamental work of the fracture concept is highly recommended as a fracture toughness test for composite laminates or quasi-brittle Material.
Investigating the Behavior of Waste Alumina Powder and Nylon Fibers for Eco-Friendly Production of Self-Compacting Concrete
Authors: Abbas Safeer , Ishaq Malik Asad Ali , Kazmi Syed Minhaj Saleem , Munir Muhammad Junaid , Ali Shahid
Published: June 2022

Self-compacting concrete (SCC) incorporating secondary raw materials has been extensively used around the globe due to its improved fresh, mechanical and durability properties. This study was planned to evaluate the suitability of locally available waste alumina powder (AP) and nylon textile fibers (NF) as a partial replacement for fine and coarse aggregates with the ultimate goal to locally produce SCC with desired properties. The used AP was acquired from a local market and NF was collected from a local textile factory. Various dosages of AP (10%, 20%, 30%, 40% and 50% by volume of fine aggregates) and NF (1% and 2% by volume of coarse aggregates) were studied. Tests including slump flow, V-funnel and J-ring tests were performed for examining the fresh properties of developed SCC. Results showed that the addition of AP has an insignificant effect on the superplasticizer dosage for maintaining a constant flow of 70 cm. However, a higher dosage of superplasticizer was required for a mixture with increasing dosages of NF to sustain a constant flow. Similarly, slump flow time (for a spread of 50 cm) and V-funnel time increased for mixtures with higher dosages of AP and NF. Tested SCC mixtures incorporating 40% and 50% of AP with 1% and 2% of NF showed an extreme blocking assessment due to their increased interparticle friction, the higher water absorption capacity of used AP and NF leading to increased flow resistance and hence, showed lower passing ability. The compressive strength was 16% higher for specimens incorporating 40% of AP due to the filling effect of AP which fills the micro-pores, leading to a more dense and compact internal micro-structure, confirmed through scanning electron microscopy analysis. An ultrasonic pulse velocity test conducted on hardened specimens verified the findings of the compressive strength results. Moreover, it was observed that NF has an insignificant effect on the compressive strength; however, flexural strength was increased due to the incorporation of NF, especially at higher dosages of AP.
Flexural Performance of Encased Pultruded GFRP I-Beam with High Strength Concrete under Static Loading
Authors: Mahmood Enas M. , Allawi Abbas A. , El-Zohairy Ayman
Published: June 2022

There is an interesting potential for the use of GFRP-pultruded profiles in hybrid GFRP-concrete structural elements, either for new constructions or for the rehabilitation of existing structures. This paper provides experimental and numerical investigations on the flexural performance of reinforced concrete (RC) specimens composite with encased pultruded GFRP I-sections. Five simply supported composite beams were tested in this experimental program to investigate the static flexural behavior of encased GFRP beams with high-strength concrete. Besides, the effect of using shear studs to improve the composite interaction between the GFRP beam and concrete as well as the effect of web stiffeners of GFRP were explored. Encasing the GFRP beam with concrete enhanced the peak load by 58.3%. Using shear connectors, web stiffeners, and both improved the peak loads by 100.6%, 97.3%, and 130.8%, respectively. The GFRP beams improved ductility by 21.6% relative to the reference one without the GFRP beam. Moreover, the shear connectors, web stiffeners, and both improved ductility by 185.5%, 119.8%, and 128.4%, respectively, relative to the encased reference beam. Furthermore, a non-linear Finite Element (FE) model was developed and validated by the experimental results to conduct a parametric study to investigate the effect of the concrete compressive strength and tensile strength of the GFRP beam. The developed FE model provided good agreement with the experimental results regarding deformations and damaged patterns.
Eye-Visible Oxygen Sensing via In-Situ Synthesizing Blue-Emitting Cu(I) Cluster in Red-Emitting COF: Characterization and Performance
Authors: Zhu Peibin , Lin Lixiong , Chen Wen , Liu Liang
Published: June 2022

Covalent organic frameworks (COFs) have shown virtues of well-defined and uniform pores with structural diversity, including the shape, size and even chemical nature of pores. These features are excellent for the application of O2 gas optical sensors. In this paper, two oxygen probes based on halogen-bridged Cu cluster were in-situ synthesized in the micropores of COFs, to allow a uniform distribution. The resulting composite samples were characterized in detail to confirm the successful probe loading. The doping level was determined as ~22%. The halogen-bridged Cu clusters showed blue emission peaking at ~440 nm, while COF host showed red emission peaking at 630 nm. These halogen-bridged Cu clusters had long emissive lifetime of ~6.7 μs and high emission quantum yield of 0.30 in pure N2 atmosphere. Given pure O2 atmosphere, lifetime and quantum yield were quenched to 2.5 μs and 0.11, showing oxygen-sensing possibility. A linear oxygen-sensing calibration curve was observed, with sensitivity of 12.25, response time of 13 s and recovery time of 38 s. Sample emission color was changed from blue to red when testing atmosphere was changed from pure N2 to pure O2, which was detectable by eyes.
Potential Method to Distinguish Copper Molten Marks Using Boundary and Grain Characteristics
Authors: Park Jinyoung , Kang Joo-Hee , Jang Hyo-Sun , Ko Young Ho , Bang Sun Bae
Published: June 2022

The microstructure of molten marks changes according to ambient temperatures, when a short circuit occurs. Investigation of microstructural changes is important for understanding the properties of copper and examining the cause of a fire. In this study, the boundary characteristics and grain-size distribution of molten marks—primary-arc beads (PABs), which short-circuited at room temperature (25 °C), and secondary-arc beads (SABs), which short-circuited at high temperatures (600 °C, 900 °C)—were compared using electron backscatter diffraction. The distribution of Σ3 boundaries was compared, and it was found that SABs have a higher fraction of Σ3 boundaries than PABs. Moreover, it was confirmed that the ratio of maximum grain size (area) to the total area of the molten mark in SABs is larger than that in PABs. Thus, reliable discriminant factors were suggested, such as the fraction of Σ3 boundaries and normalized maximum grain size, which can distinguish PABs and SABs. The four discriminant factors, such as the (001)//LD, GAR, fraction of Σ3 boundaries, and fraction of maximum grain size to the total molten-mark area, were verified using the machine learning of t-SNE and Pearson correlation analyses.
Recent Discoveries on Marine Organism Immunomodulatory Activities
Authors: Montuori Eleonora , de Pascale Donatella , Lauritano Chiara
Published: June 2022

Marine organisms have been shown to be a valuable source for biologically active compounds for the prevention and treatment of cancer, inflammation, immune system diseases, and other pathologies. The advantage of studying organisms collected in the marine environment lies in their great biodiversity and in the variety of chemical structures of marine natural products. Various studies have focused on marine organism compounds with potential pharmaceutical applications, for instance, as immunomodulators, to treat cancer and immune-mediated diseases. Modulation of the immune system is defined as any change in the immune response that can result in the induction, expression, amplification, or inhibition of any phase of the immune response. Studies very often focus on the effects of marine-derived compounds on macrophages, as well as lymphocytes, by analyzing the release of mediators (cytokines) by using the immunological assay enzyme-linked immunosorbent assay (ELISA), Western blot, immunofluorescence, and real-time PCR. The main sources are fungi, bacteria, microalgae, macroalgae, sponges, mollusks, corals, and fishes. This review is focused on the marine-derived molecules discovered in the last three years as potential immunomodulatory drugs.
Relationship between the Accuracy of the Acetabular Cup Angle and BMI in Posterolateral Total Hip Arthroplasty with CT-Based Navigation
Authors: Ishikura Hisatoshi , Nakamura Masaki , Nakamura Shigeru , Tanaka Takeyuki , Kawano Hirotaka , Tanaka Sakae
Published: June 2022

Background and Objectives: Precise acetabular cup placement is essential for successful total hip arthroplasty (THA). In obese patients, its accuracy is often difficult to achieve because of the thickness of the soft tissues. This study aimed to determine the relationship between the accuracy of acetabular cup angle and body mass index (BMI) in posterolateral THA using the computed tomography-based navigation (CT-navi) system. Materials and Methods: We retrospectively reviewed 145 consecutive primary THAs using the CT-navi system between January 2015 and January 2018. All surgeries were performed using cementless cups employing the posterolateral approach with the patient in the decubitus position. We compared the radiographic inclination and anteversion obtained intraoperatively from the CT-navi with those measured by postoperative CT using three-dimensional templating software. We evaluated the relationship between the extent of errors and correlation with BMI. Results: In non-overweight patients (BMI < 25, 88 hips), the mean navigation errors for inclination were 2.8 ± 2.2° and for anteversion were 2.6 ± 2.3°. Meanwhile, in overweight patients (BMI ≥ 25, 57 hips), the mean navigation errors were 2.6 ± 2.4° for inclination and 2.4 ± 2.4° for anteversion. We found no significant difference between overweight and non-overweight patients in both inclination and anteversion. There was no correlation between the extent of errors and BMI. Conclusions: In posterolateral THA, CT-navi can aid the precise placement of the acetabular cup irrespective of a patient’s BMI.
Continuous Implant Load Monitoring to Assess Bone Healing Status—Evidence from Animal Testing
Authors: Windolf Markus , Varjas Viktor , Gehweiler Dominic , Schwyn Ronald , Arens Daniel , Constant Caroline , Zeiter Stephan , Richards Robert Geoff , Ernst Manuela
Published: June 2022

Background and Objectives: Fracture healing is currently assessed through qualitative evaluation of radiographic images, which is highly subjective in nature. Radiographs can only provide snapshots in time, which are limited due to logistics and radiation exposure. We recently proposed assessing the bone healing status through continuous monitoring of the implant load, utilizing an implanted sensor system, the Fracture Monitor. The device telemetrically transmits statistically derived implant parameters via the patient’s mobile phone to assist physicians in diagnostics and treatment decision-making. This preclinical study aims to systematically investigate the device safety and performance in an animal setting. Materials and Methods: Mid-shaft tibial osteotomies of different sizes (0.6–30 mm) were created in eleven Swiss mountain sheep. The bones were stabilized with either a conventional Titanium or stainless-steel locking plate equipped with a Fracture Monitor. Data were continuously collected over the device’s lifetime. Conventional radiographs and clinical CT scans were taken longitudinally over the study period. The radiographs were systematically scored and CTs were evaluated for normalized bone volume in the defect. The animals were euthanized after 9 months. The sensor output was correlated with the radiologic parameters. Tissue samples from the device location were histologically examined. Results: The sensors functioned autonomously for 6.5–8.4 months until energy depletion. No macroscopic or microscopic adverse effects from device implantation were observed. The relative implant loads at 4 and 8 weeks post-operation correlated significantly with the radiographic scores and with the normalized bone volume metric. Conclusions: Continuous implant load monitoring appears as a relevant approach to support and objectify fracture healing assessments and carries a strong potential to enable patient-tailored rehabilitation in the future.
The Short-Term Opening of Cyclosporin A-Independent Palmitate/Sr2+-Induced Pore Can Underlie Ion Efflux in the Oscillatory Mode of Functioning of Rat Liver Mitochondria
Authors: Belosludtseva Natalia V. , Pavlik Lyubov L. , Belosludtsev Konstantin N. , Saris Nils-Erik L. , Shigaeva Maria I. , Mironova Galina D.
Published: June 2022

Mitochondria are capable of synchronized oscillations in many variables, but the underlying mechanisms are still unclear. In this study, we demonstrated that rat liver mitochondria, when exposed to a pulse of Sr2+ ions in the presence of valinomycin (a potassium ionophore) and cyclosporin A (a specific inhibitor of the permeability transition pore complex) under hypotonia, showed prolonged oscillations in K+ and Sr2+ fluxes, membrane potential, pH, matrix volume, rates of oxygen consumption and H2O2 formation. The dynamic changes in the rate of H2O2 production were in a reciprocal relationship with the respiration rate and in a direct relationship with the mitochondrial membrane potential and other indicators studied. The pre-incubation of mitochondria with Ca2+(Sr2+)-dependent phospholipase A2 inhibitors considerably suppressed the accumulation of free fatty acids, including palmitic and stearic acids, and all spontaneous Sr2+-induced cyclic changes. These data suggest that the mechanism of ion efflux from mitochondria is related to the opening of short-living pores, which can be caused by the formation of complexes between Sr2+(Ca2+) and endogenous long-chain saturated fatty acids (mainly, palmitic acid) that accumulate due to the activation of phospholipase A2 by the ions. A possible role for transient palmitate/Ca2+(Sr2+)-induced pores in the maintenance of ion homeostasis and the prevention of calcium overload in mitochondria under pathophysiological conditions is discussed.
Autopsy of Used Reverse Osmosis Membranes from the Largest Seawater Desalination Plant in Oman
Authors: Al-Abri Mohammed , Kyaw Htet Htet , Al-Ghafri Buthayna , Myint Myo Tay Zar , Dobretsov Sergey
Published: June 2022

The Barka desalination plant, commissioned in 2018, is the largest desalination plant in Oman. It has a capacity of 281 MLD with a reverse osmosis (RO) first-pass recovery rate of 46%. As part of the standard operator practice, a membrane autopsy was conducted to determine the cause of reductions in membrane performance. This study investigated fouled membranes (model No. SW30HRLE-440) from two different locations in the membrane rack. Various analytical methods were used to conduct the membrane autopsy. Field-emission scanning electron microscopy/energy-dispersive X-ray (FESEM/EDS) analyses of membrane samples showed major components of inorganic foulants. Moreover, black and salt-like crystals deposited on the membrane surface revealed significant carbon (C) components and oxygen (O), with a small amount of magnesium (Mg), chloride (Cl), sodium (Na), aluminium (Al), and calcium (Ca), respectively. A Fourier transform infrared (FTIR) analysis revealed the presence of long-chain hydrocarbons, carboxylic acids/esters, carbohydrates/polysaccharides, and inorganic foulants. Thermogravimetric analyses (TGA) of the membranes showed a high initial weight loss due to organic and inorganic fouling. X-ray photoelectron (XPS) analyses further confirmed the presence of inorganic and organic foulants on the membrane surfaces. Bacteria identification results showed the presence of Bacillus cereus and Bacillus marisflavi. This paper offers a detailed analysis of the foulants present on the reverse osmosis membrane surface and sub-surface before and after a cleaning process.
Topological and Mechanical Properties of Different Lattice Structures Based on Additive Manufacturing
Authors: Teng Fei , Sun Yongguo , Guo Shuai , Gao Bingwei , Yu Guangbin
Published: June 2022

The appearance and development of additive manufacturing technology promotes the production and manufacture of parts with more complex designs and smaller sizes and realizes the complex topology that cannot be made by equal-material manufacturing and submanufacturing. Nowadays, the application of tri-periodic minimal surface (TPMS) in topology optimization design has become a new choice, and, because of its excellent structure and properties, has gradually become mainstream. In this paper, the mechanical properties of four different topologies prepared by selective laser melting (SLM) using 316L stainless steel powder were investigated, including two TPMS sheet structures (Primitive surface, Gyroid surface) and two common lattice structures (Bcc lattice, truss lattice). The mechanical properties (Young’s modulus, yield stress, plateau stress, and toughness) were compared by numerical simulation and compression experiment. It can be concluded from the results that the mechanical properties and deformation mechanism of the specimen are mainly related to the type of lattice, though have little relationship with unit thickness at the same relative density. The Gyroid curved structure showed the best mechanical properties and energy absorption capacity, followed by the truss lattice structure. By comparison, the mechanical properties of the traditional Bcc lattice structure and the Primitive surface structure are poor, and the deformation mechanism of these two structures is uncertain and difficult to control.
Use of PtC Nanotips for Low-Voltage Quantum Tunneling Applications
Authors: Haub Michael , Guenther Thomas , Bogner Martin , Zimmermann André
Published: June 2022

The use of focused ion and focused electron beam (FIB/FEB) technology permits the fabrication of micro- and nanometer scale geometries. Therefore, FIB/FEB technology is a favorable technique for preparing TEM lamellae, nanocontacts, or nanowires and repairing electronic circuits. This work investigates FIB/FEB technology as a tool for nanotip fabrication and quantum mechanical tunneling applications at a low tunneling voltage. Using a gas injection system (GIS), the Ga-FIB and FEB technology allows both additive and subtractive fabrication of arbitrary structures. Using energy dispersive X-ray spectroscopy (EDX), resistance measurement (RM), and scanning tunneling microscope (STM)/spectroscopy (STS) methods, the tunneling suitability of the utilized metal–organic material–platinum carbon (PtC) is investigated. Thus, to create electrode tips with radii down to 15 nm, a stable and reproducible process has to be developed. The metal–organic microstructure analysis shows suitable FIB parameters for the tunneling effect at high aperture currents (260 pA, 30 kV). These are required to ensure the suitability of the electrodes for the tunneling effect by an increased platinum content (EDX), a low resistivity (RM), and a small band gap (STM). The STM application allows the imaging of highly oriented pyrolytic graphite (HOPG) layers and demonstrates the tunneling suitability of PtC electrodes based on high FIB aperture currents and a low tunneling voltage.
Excitation of Hybrid Waveguide-Bloch Surface States with Bi2Se3 Plasmonic Material in the Near-Infrared Range
Authors: Li Hongjing , Zheng Gaige
Published: June 2022

Bloch surface waves (BSWs) with Bi2Se3 in a composite structure consisting of a coupling prism, distributed Bragg reflector (DBR) and cavity layer have been demonstrated. The design relies on the confinement of surface waves that originates from the coupling between the defective layer of plasmonic material (Bi2Se3) and DBR. The presence of the cavity layer modifies the local effective refractive index, enabling direct manipulation of the BSWs. The transfer matrix method (TMM) is used to evaluate the reflectance and absorptance responses in the spectral domain for various angles of incidence, demonstrating the presence of sharp resonances associated with the BSW. With an optimal thickness of DBR bilayers, the energy of an evanescent wave can be transferred into the periodic stack resulting in the excitation of waveguide modes (WGMs). It is believed that the proposed design possesses the advantage in terms of easy fabrication to develop integrated photonic systems, especially for biological and chemical sensing.