bluuebunny/crossref_metadata_2025 huggingface dataset:
Antihypertensive drug amlodipine besylate shows potential in alleviating diabetic peripheral neuropathy
Authors: Wei Yuxi , Huang Yujie , Huang Runzhi , Ruan Yuan , Feng Tian , Zhou Fan , Zhang Wei , Lu Jianyu , Xie Sujie , Yao Yuntao , Wang Jiaying , Ji Shizhao , Shen Xu
Published: February 2025

Diabetic peripheral neuropathy (DPN) is a common diabetic complication with no currently available curative treatments. Here, we demonstrated that the protein level of G-protein-coupled receptor 40 (GPR40) is significantly repressed in the sciatic nerves (SN) of DPN patients, as well as in the peripheral nerves, including dorsal root ganglia (DRG) and SN, of streptozotocin (STZ)-induced type 1 diabetic mice and BKS Cg-m+/+Lepr db/J (db/db) type 2 diabetic mice. We identified that amlodipine besylate (AB), a first-line clinical antihypertensive drug, as a GPR40 agonist capable of alleviating DPN-like pathologies in mice. These pathologies include neurological damage, destruction of myelin sheath structures, vascular injury, loss of intraepidermal nerve fibers, and impaired neurite outgrowth in DRG neurons. To elucidate the underlying mechanisms, we generated the DPN mice with GPR40-specific knockdown in SN and DRG tissues using adeno associated virus 8-GPR40-RNAi. Mechanistically, AB attenuated inflammatory responses via the GPR40/β-arrestin2/NLRP3 pathway and ameliorated mitochondrial dysfunction through the GPR40/LKB1/AMPK/SIRT1/PGC-1α pathway in DPN mice, which were all further validated in primary human Schwann cells. Additionally, AB suppressed the crosstalk between Schwann cells and endothelial cells /DRG neurons in DPN mice. Collectively, our findings highlight the potential of AB for the treatment of DPN.
Intermittent Low-Magnitude Pressure Applied Across Macroencapsulation Devices Enables Physiological Insulin Delivery Dynamics
Authors: A. Thomson Ella , Lee Sooyeon , Xu Haixia , Moeller Hannah , Sands Joanna , A. Lal Rayhan , P. Annes Justin , S. Y. Poon Ada
Published: February 2025

Cadaveric islet and stem cell-derived transplantation hold promise as treatments for type 1 diabetes (T1D). To tackle the issue of immunocompatibility, numerous cellular macroencapsulation techniques that utilize diffusion to transport insulin across an immunoisolating barrier have been developed. However, despite several devices progressing to human clinical trials, none have successfully attained physiologic glucose control or insulin independence. Based on empirical evidence, macroencapsulation methods with multilayered, high islet surface density are incompatible with on-demand insulin delivery and physiologic glucose regulation, when solely reliant on diffusion. An additional driving force is essential to overcome the distance limit of diffusion. In this study, we present both theoretical evidence and experimental validation that applying pressure, at levels comparable to physiological diastolic blood pressure, significantly enhances insulin flux across immunoisolation membranes—increasing it by nearly three orders of magnitude. This significant enhancement in transport rate allows for precise, sub-minute regulation of both bolus and basal insulin delivery. By incorporating this technique with a pumpbased extravascular system, we demonstrate the ability to rapidly reduce glucose levels in diabetic rodent models, replicating the timescale and therapeutic effect of subcutaneous insulin injection or infusion. This advance provides a potential path towards achieving insulin independence with islet macroencapsulation.
CONSTRUÇÃO DE UM GUIA INFORMATIVO SOBRE BENEFÍCIOS DO GOVERNO BRASILEIRO PARA POPULAÇÕES ESPECÍFICAS
Authors: Santos Gabrielle da Silveira , Santos Tânita Maria Souza , Santos Mairon Marques dos , Barros Cláudia Correia da Silva , Monteiro Eneida Aparecida Machado , Faria Filho Fausto de Melo
Published: February 2025

Este relato de experiência descreve o planejamento e a construção de um guia informativo voltado para populações específicas do Vale do São Patrício, com o objetivo de promover a conscientização sobre políticas de assistência social. Para embasar o desenvolvimento do guia, foi realizado um levantamento da realidade socioeconômica da região, seguido de uma análise das políticas de assistência social em vigor. A partir dessas informações, foram identificadas lacunas no conhecimento da população, que orientaram a criação do Guia Cadastro Único: conhecendo a política de assistência social para grupos populacionais do Vale do São Patrício. O guia foi disponibilizado gratuitamente na página do Instituto Federal Goiano – Campus Ceres, como parte de um projeto de extensão, com o intuito de facilitar o acesso da população às informações. O projeto foi desenvolvido de forma participativa e colaborativa. A iniciativa dependeu do engajamento de diversos atores sociais, incluindo órgãos governamentais, organizações da sociedade civil e lideranças comunitárias.
ÉTICA DA LIBERTAÇÃO E PRÁTICAS EDUCATIVAS: FUNDAMENTOS PARA UMA PEDAGOGIA DA ALTERIDADE
Authors: Paula Wagner Eduardo Estácio de , Santos João Derli de Souza , Braz André Luiz de Oliveira , Rosa Josely Cristiane , Silva Edineia Pereira da
Published: February 2025

Considerando que a Ética da Libertação de Enrique Dussel é de suma relevância para a educação e ainda, explora como seus princípios podem fundamentar práticas pedagógicas voltadas para a inclusão e para a justiça social, fundamentado também no conceito de alteridade, discutindo a necessidade de uma abordagem educacional que valorize os saberes marginalizados e desafie estruturas opressivas no ambiente escolar. Desta forma, objetiva-se analisar como a Ética da Libertação pode fundamentar práticas educativas críticas e transformadoras, dialogando com a pedagogia freireana e outros referenciais que destacam a importância da escuta ativa e do compromisso ético com os educandos. Para tanto, proceder-se-á uma pesquisa bibliográfica com base em materiais já elaborados, constituído principalmente de livros e artigos científicos, que serão particularmente vantajosos para a obtenção dos dados dispersos pelo espaço acadêmico. Desse modo, a pesquisa destaca a importância da reformulação curricular, da adoção de metodologias ativas e da formação docente crítica como elementos essenciais para promover um ensino comprometido com a transformação social. O que permite concluir que a Ética da Libertação oferece um referencial teórico e prático fundamental para construir uma educação mais equitativa e emancipadora.
Criteria and Indicators of the Formation of the Ethno-Singing Culture of Students of the University of Culture
Authors:   St. Petersburg State University of Culture, St. Petersburg, Shastina Tatiana V.
Published: February 2025

The relevance of the issue concerning the formation of ethno-singing culture in individuals is underscored by the examination of the organization of professional training for students in higher education institutions of cul-ture, the effectiveness of pedagogical technologies, generalization of pedagogical experience and forecasting the prospects of ethnocultural education. Today, this field, by transmitting the culture of the past, actively influ-ences the state of modern folk vocal and musical art, updating it through the cultivation of individuals who pos-sess both knowledge of folk singing traditions and the ability to perceive and reproduce works of art of the oral tradition, combined with new musical thinking. Ethnovocal education is defined by the author as a multifaceted process of communication, serving as an institution that enables the preservation of the singing culture of an ethnic group through its reconstruction, while also allowing for its development through the creative activities of individuals. The article emphasizes the appropriateness of implementing a specifically organized early ethno-vocal education for each individual, aimed at mastering their native local singing culture and later becoming familiar with the values of other folk cultures. This requires the professional training of ethnocultural teachers with a high level of ethno-singing culture.
Actualization of Students’ Creative Potential in the Process of Forming Linguistic and Cultural Competence in Teaching Russian as a Foreign Language in the Republic of Uzbekistan
Authors:   Branch of Kazan (Volga Region) Federal University, Kolesnikova Galina I. , Kalinin Viktor A. ,   Branch of Kazan (Volga Region) Federal University
Published: February 2025

The article offers a proven method of using the creative potential of students in the formation of linguistic and cultural competence in the process of teaching Russian as a foreign language. The methodology was created on the basis of theoretical scientific works of the existential-humanistic direction. The implementation of this methodology was conducted at Dzhizag University during the 2022/2023 and 2023/2024 academic years. The contribution to the study of the actualization of students’ creative potential in the process of forming linguistic and cultural competence in teaching Russian as a foreign language by Professor G.I. Kolesnikova is that based on her work on the concept of “creativity”, the structure of the creative process, the specifics of the qualities of a creative personality A method was developed jointly with V.A. Kalinin for the development of a personality ca-pable of resisting manipulative influence. V.A. Kalinin’s contribution to the research consisted in the develop-ment of a methodology and its subsequent implementation in the pedagogical process.
Agrilus (Anambus) kubani Bílý, 1991 in Romania (Coleoptera, Buprestidae)
Authors:   " Oceanographic Research and Marine  Environment Protection Society  “Oceanic-Club”, Decebal no. 41, 900674  Constanța, Romania", Manci Cosmin , Curletti Gianfranco ,   " c/o Museo Civico di Storia Naturale,  10022 Carmagnola, Italy"
Published: February 2025

The occurrence of Agrilus kubani Bílý, 1991 is reported for the first time in Romania. This study provides details on its distribution within the country, along with information on its biological characteristics and morphological description, contributing to a better understanding of this species
Acción colectiva, normas sociales y percepción normativa: el esquema de Coleman
Authors: Hasrun Hipólito , Senci Maximiliano
Published: February 2025

Existen dos niveles de acción, el de la acción colectiva (macro) y el de la individual (micro), que se influyen mutuamente: el macro condiciona las preferencias y oportunidades individuales; las acciones individuales causan los fenómenos macro. Por ello, si bien el objetivo central de las ciencias sociales es explicar los fenómenos sociales, deben también explicar cómo la acción colectiva influye en la individual. Es común ejemplificar lo dicho apelando al “esquema de Coleman”, que ha desempeñado una función heurística en la investigación sociológica. Se argumenta en este trabajo que no todos los fenómenos de acción colectiva son como pretende el esquema, es decir, “objetivos” o comunes a todos los individuos, por lo que el esquema y la metodología requerirían una revisión. En particular, el esquema de Coleman requeriría una revisión para acomodar la distinción entre la acepción descriptiva de norma social, esto es, qué hace la gente normalmente, y la prescriptiva, es decir, cómo debe actuar una persona en determinada situación: son epistemológicamente (y ontológicamente) diferentes, y ambas tienen gran relevancia explicativa para la conducta individual. Además, aportaremos una discusión sobre la percepción de normas sociales y su relevancia en conductas sociales secretas, como la corrupción.
Demandas, estrategias discursivas y posicionamientos de los actores de poder sobre la distribución de los recursos y la política económica de Cambiemos
Authors: Fair Hernán
Published: February 2025

Este trabajo estudia la constitución de las demandas, las estrategias discursivas y las luchas hegemónicas entre el gobierno de Macri y los representantes del capital y el trabajo en torno a la política económica de Cambiemos, en los inicios de la gestión macrista. Como resultado de la investigación, se halló una intensa pugna hegemónica sobre la distribución de los recursos económicos y las consecuencias del modelo cambiemita. Dentro del campo popular se encontraron diferencias en las demandas, en los grados de combatividad y en las estrategias de acción política, con sectores más conciliadores y otros relacionalmente más confrontativos. En el empresariado se encontraron demandas en tensión frente a los efectos de la devaluación y la apertura comercial. Por último, se halló una respuesta selectiva del gobierno de Macri, que priorizó la satisfacción de las demandas particulares del capital agroexportador, el sector bancario-financiero y los economistas ortodoxos, en desmedro de las demandas de protección de la industria nacional vinculada al mercado interno. A su vez, frente a los reclamos del campo popular, el Gobierno postergó sus demandas primordiales para recomponer los salarios, y buscó anular o desactivar sus reclamos para cobrar un bono salarial, prohibir los despidos y suspensiones de trabajadores y realizar una reforma tributaria y financiera. A cambio, se limitó a ofrecer medidas mínimas de compensación económica, legitimadas en una estrategia retórica del “realismo” político y la espera. De este modo, en un contexto de fuerte devaluación y alta inflación, convalidó, por omisión, la caída en el poder adquisitivo de trabajadores y jubilados.
Analisis Kondisi Peta Persebaran Pencahayaan dan Kebisingan di PT. Pamapersada Nusantara Distrik Baya Menggunakan Software Surfer
Authors: R Andrian , Munir Rahmawati , Putri Devina , Wardani Wardani , Mislan Mislan
Published: February 2025

Penelitian ini dilatarbelakangi dengan adanya masalah pencahayaan dan kebisingan di perusahaan pertambangan. Pencahayaan yang kurang dapat menyebabkan kecelakaan dan kelelahan mata, sementara kebisingan dari alat berat dapat menyebabkan gangguan kesehatan dan menurunkan kinerja para pekerja. Oleh sebab itu penelitian ini bertujuan untuk mengidentifikasi dan memetakan area-area dengan tingkat pencahayaan dan kebisingan di PT. Pamapersada Nusantara Distrik Baya, serta menganalisis peta persebarannya berdasarkan SNI 16-7062-2004 untuk pencahayaan dan SNI 8427:2017 untuk kebisingan. Hasil penelitian menunjukkan bahwa variasi dalam tingkat pencahayaan dan kebisingan di berbagai area, hal ini disebabkan adanya beberapa faktor yang mempengaruhi seperti penghalang sumber cahaya seperti unit besar yang sedang parkir di area yang diukur dan waktu jam kerja. Area dengan pencahayaan kurang optimal seringkali menghambat tugas pekerja, sementara area dengan kebisingan tinggi berpotensi menyebabkan gangguan pendengaran. Kesimpulan dari penelitian ini menunjukkan bahwa identifikasi variasi tingkat pencahayaan dan kebisingan cukup tinggi di area kerja PT. Pamapersada Nusantara Distrik Baya yang disebabkan oleh kondisi lingkungan disaat jam kerja. Rekomendasi yang diberikan oleh PT. Pamapersada Nusantara Distrik Baya untuk meningkatkan kenyamanan dan kinerja karyawan adalah pemerataan dan pemeliharaan serta pengadaan infrastruktur pencahayaan maupun kebisingan.
From Praying Hands to Killing Hands: The Metaphor of the Hands in the Romanian War Novel of the Interwar Period
Authors: Blăjan Iuliana-Gabriela
Published: February 2025

There is no doubt that the grim reputation of the First World War is mainly due to the immense loss of human life, but the great calamity of the 20th century involved many other developments; among them, in first place, are those of a technological nature. The tragedy of a developing world was that technology joined hands with the tide of power that was sweeping Europe from one end to the other, leading to the outbreak of a hitherto unparalleled war and, by implication, dictating the extremely brutal manner in which it was conducted. Although in figurative language the idea of power is closely linked to the hand, as a symbol of strength, determination and resistance, in the repertoire of the novels investigated, the symbolic value of the human hand has a much wider range of meanings. This is what the present study aims to highlight: not only that the hand is a word that is not absent from the vocabulary of war novels, since weapons are carried by hands, but also that the symbolism of the hand tends to eclipse the idea of force, understood as an arbitrary way of imposing oneself on the adversary. As war claims more and more victims, proving to be a colossal human error, the symbolism of the hand undergoes a commensurate transmutation. As an antithesis of the idea of power, it often suggests not only weakness, the loss of physical and mental strength, but above all the acute need for compassion and solidarity in the face of suffering.
The Effective Influence of Adsorbate-Adsorbate Associations on the Two-Dimensional Condensation of a Mobile Adsorption Monolayer on a Homogeneous Solid Adsorbent Surface
Authors: Garbacz Jerzy K. , Kopkowska Ewa , Kozakiewicz Mariusz , Siermontowski Piotr
Published: February 2025

The study employed the formalism of the canonical ensemble to analyze adsorption equilibrium, assuming that linear association of molecules is the only type of attractive interaction in the mobile monolayer on a homogeneous solid adsorbent surface. The partition function of the canonical ensemble was related to the free energy and the chemical potential of the adsorbate. The initial model did not show the possibility of two-dimensional condensation of the adsorbate, confirming the analogy to the one-dimensional Ising model.

The generalization of the model, assuming a branched form of adsorbate-adsorbate associates, leads to a new adsorption equation that takes into account the number of centers favorable for association. The introduction of the concept of multidimensional association enabled the derivation of an adsorption equation, which was analyzed with respect to the critical point of the adsorption layer condensation. This analysis showed that condensation is possible if the number of such centers is greater than two. The critical values of the association constant and the degree of surface coverage are functions of the number of association centers. These results demonstrate that the formalism of the canonical ensemble is effective for describing adsorption equilibrium with linear association of molecules, and that generalizing the model to include branched associates leads to a new adsorption equation predicting two-dimensional condensation of the adsorbate under certain conditions.

The described model introduces new solutions in the use of sorbents in diving apparatus with a closed circuit and thus increasing their efficiency in military applications.
The Motor Determinants of the Recruitment of Candidates for Naval Special Forces in the Opinion of the Founder of the Special Military JW. Formoza
Authors: Różański Paweł
Published: February 2025

The study concerns an expert interview conducted with Lieutenant commander Major Józef Rembisz, the founder and first commander of the Formosa Special Military Unit. The interview was realised on 28.01.2018 in Gdynia, at Skwer Kościuszki. The meeting with Mr Józef Rembisz was attended by 25 students of the Uniformed Services Branch of the Academy of Physical Education from Biała Podlaska. The purpose of the interview was to hear from the founder and at the same time experienced commander of the aforementioned special unit about the contemporary trends and interests of young people in this type of forces as well as the possibilities of their fitness preparation for marine special forces. During the meeting, the interviewee brought up historical aspects, presented his biography, and presented his position resulting from observations and reflections on the current possibilities for the preparation of contemporary generations of candidates for selection, i.e. the main test carried out in the Polish special forces. The observations given by the interviewee were aimed at making the listeners aware of the direction they should follow in order to appropriately model their motor skills in order to adequately prepare for the aforementioned selection. The results of the interview are the thoughts and suggestions of an experienced commander of the aforementioned special forces unit suggesting the direction that should be followed by contemporary candidates interested in joining the service in special forces.
Percutaneous coronary intervention using isoosmolar contrast agent in an end-stage renal failure patient: a case report
Authors: Le Duy Cao Phương , Bui Hoa The , Vo Quan Duy
Published: February 2025

Background

Managing acute myocardial infarction (AMI) in end-stage renal failure (ESRF) patients poses challenges, particularly the risk of contrast-induced nephropathy (CIN) during percutaneous coronary intervention (PCI). This case highlights the successful use of iodixanol, an iso-osmolar contrast agent, in an ESRF patient who declined dialysis with no renal function deterioration. It underscores the potential of iodixanol in safely managing high-risk patients, offering insights for clinical practice.

Case presentation

A 79-year-old male with non-ST-elevation myocardial infarction (NSTEMI) and end-stage renal failure (ESRF), who had declined dialysis, underwent PCI using iodixanol. Coronary angiography revealed significant left main and triple vessel disease, and coronary artery bypass grafting (CABG) was declined by the patient. A second intervention was performed one week later due to persistent symptoms. Post-procedural monitoring revealed stage 1 acute kidney injury (AKI), which was successfully managed with intravenous fluid therapy. Renal function stabilized after the second procedure, and the patient was discharged one week later.

Conclusion

The use of iodixanol in ESRF patients undergoing PCI without dialysis appears to be a favorable option. Further studies are needed to guide contrast agent selection in this high-risk group.
The Relationship Between the Mental Health of Slovenian Adolescents and the Support of their Various Personal Social Networks
Authors: KNEZ Anja , MAKIVIĆ Irena , JERIČEK KLANŠČEK Helena
Published: February 2025

Aim

To analyse the relationships between individual social networks and selected indicators of mental health among Slovenian adolescents aged 15 and 17.

Methods

Data from the international Health Behaviour in School-aged Children (HBSC) survey in 2018 were used. Cronbach’s alpha coefficient was used to calculate the reliability of the scales. Data were presented using descriptive statistics and frequency distributions. Differences between the two groups were determined using the chi-square or t-test. Pearson’s correlation coefficient was used to test the associations. Multiple linear regression was also used to explain adolescents’ mental health.

Results

The mental health of adolescents is statistically significantly related to the experience of support in their social networks (p≤0.05). Adolescents with better mental health differ from those with poorer mental health in the degree to which they experience support from their social networks. Support from a greater number of social networks is statistically significantly associated with lower perceived stress and the risk of depression. In explaining adolescents’ good mental health, the support of the school environment, i.e. classmates and teachers, proved to be more important than the support of the family.

Conclusions

The support of personal social networks is essential for good mental health in young people. In practice, it would be reasonable to strengthen the support of teachers and classmates, as the school environment proved to be a very important source of support at that age.
Cultural Adaptation of Patient-Reported Indicator Surveys (PaRIS) Patient and Primary Care Practice Questionnaires to the Slovenian Context
Authors: AMBROŽ Matija , ROPRET Nina , VRAČKO Pia , MURKO Eva , KENDIR Candan , BOSNJAK Lucija , WILLIAMS Rachel , KLEMENC-KETIŠ Zalika
Published: February 2025

Introduction

The objective of the study is to describe the adaptation process (with emphasis on cognitive testing) of the Slovenian version of the PaRIS international survey, including two questionnaires to assess patient-reported health outcomes and the experiences of adults living with one or more chronic conditions managed in primary care settings: (1) Patient questionnaire (targets patients aged 45 and older) and (2) Provider questionnaire (targets health care providers working in primary care).

Methods

The translation process of both PaRIS questionnaires followed a team-based double translation and reconciliation approach. Cognitive interviewing with 29 participants was performed. An analysis grid and debriefing were implemented, and the cognitive testing rating was assessed for each tested question. Cross-national error source typology (CNEST) was used.

Results

The results of cognitive interviewing revealed difficulties in 30 questions / segments (out of a total of 44 tested) in the Patient questionnaire and difficulties in 23 questions / segments (out of a total of 24 tested) in the Provider questionnaire. In both questionnaires most difficulties were identified as poor source question design.

Conclusions

Our study showed that cognitive interviewing is a crucial step in questionnaire adaptation, especially while transferring internationally developed questionnaires on Patient Reported Experience Measures and Patient Reported Outcome Measures into different national contexts. Through a rigorous process of translation and cognitive testing, we obtained better quality PREMs and PROMs measures in the Slovenian language. However, the measurement tools need to be piloted, and psychometrically evaluated in future to test reliability and validity.
A COMPARISON BETWEEN TWO ROMANIAN DEVELOPMENT REGIONS FROM A SMART CITY PERSPECTIVE
Authors: GONTEAN Alexandra , TRINCĂ Vlad-Tudor
Published: February 2025

Smart city initiatives are becoming more visible nowadays in Eastern Europe, due to the rapid steps taken in terms of digitalization during the pandemic and the funding opportunities available. The comparison of two Romanian development regions will be the main focus of this study, which will highlight the fact that there are no notable differences between the two development regions while demonstrating that a number of factors influence the degree of smart city project implementation within the communities. Both interested parties and academics studying the smart city framework may find value in the study's findings.
Retrospective Evaluation and Analysis of Pharmacoequity with Guideline-directed Medical Therapy in Heart Failure with Reduced Ejection Fraction (REAP-HF)
Authors: Streett Morgan , Jacobs Anna , Twilla Jennifer , Duncan Kaulin , Nadella Geeth , Wells Drew
Published: February 2025

Introduction: Patients with heart failure with reduced ejection fraction (HFrEF) who are optimized on guideline-directed medical therapy (GDMT) have improved outcomes; however, medication access and affordability are potential barriers to achieving pharmacoequity. This study sought to compare rates of HFrEF GDMT prescribing at hospital discharge across prescription insurance status groups.
Methods: This was a single-center, retrospective cohort study of adult HFrEF patients. Patients were grouped according to prescription insurance status. The primary outcome was the percentage of HFrEF patients prescribed quadruple GDMT at hospital discharge. Key secondary outcomes included the presence of contraindications to therapy and 30-day all-cause readmission rates. The study was approved by the Institutional Review Board at the University of Tennessee Health Science Center.
Results: Among the 200 included patients, 63% were male and 92% were black. Discharge on quadruple GDMT across insurance groups was 18% for Medicare Part D, 24% for Medicaid, 24% for commercial, and 33% for uninsured. There was no difference between insurance groups in rates of prescribed quadruple GDMT at hospital discharge (p=0.302) or 30-day hospital readmission (p=0.665). Additionally, there was a significant increase in the number of uninsured patients on quadruple GDMT after hospitalization compared to pre-hospitalization (13% vs 33%, p=0.002). Eighty percent of all patients had a contraindication to at least one GDMT agent.
Conclusion: There was no difference in rates of prescribed quadruple GDMT at hospital discharge based on insurance status. However, this study did elucidate the impact of medication access programs improving pharmacoequity in a vulnerable patient population.
LIGA ACADÊMICA DE CLÍNICA MÉDICA (LACLIMED): RELATO DE EXPERIÊNCIA DOS ESTUDANTES DE MEDICINA EM UMA UNIVERSIDADE DO NOROESTE PAULISTA
Authors: LIMA Alice Ferreira de , CASARE Ana Carolina Ribeiro de Lacerda , MARTINS Edilaine Jaqueline G. , SILVA Elisiane Cássia Bono da , GOMES Laís , ALCAMIM Thaniê Gomes
Published: February 2025

As ligas acadêmicas no curso de medicina propiciam uma vantagem no desenvolvimento dos estudantes, haja vista a forma dinâmica e ativa com as quais os próprios acadêmicos planejam e executam suas atividades. O objetivo deste trabalho foi discorrer sobre as experiências vivenciadas na Liga de Clínica Médica (Laclimed), do Centro Universitário de Santa Fé do Sul - Unifunec, a fim de afirmar a relevância da participação dos estudantes de medicina nas atividades extracurriculares oferecidas pelo curso acadêmico, baseando-se nos princípios do tripé universitário: ensino, pesquisa e extensão. O presente relato de experiência tem caráter descritivo e qualitativo. Para sua elaboração, foram escolhidas 4 atividades principais, às que foram vivenciadas pelos estudantes da Laclimed durante o período letivo do ano de 2023. As atividades descritas envolvem reuniões quinzenais, ações com a comunidade, evento acadêmico e formação complementar. Concluiu-se que a existência das Ligas Acadêmicas contribui para a formação extracurricular dos estudantes de medicina, a partir da complementação da carga horária universitária, pois promove o desenvolvimento do currículo oculto.
 
ACADEMIC LEAGUE OF CLINICAL MEDICINE (LACLIMED): REPORT ON THE EXPERIENCE OF MEDICAL STUDENTS AT A UNIVERSITY IN THE NORTHWEST OF SÃO PAULO
 
ABSTRACT
Academic leagues in the medical course provide an advantage in the development of students, given the dynamic and active way in which the academics themselves plan and execute their activities. The objective of this work was to discuss the experiences lived in the Medical Clinic League (Laclimed), at the Centro Universitário de Santa Fé do Sul - Unifunec, in order to affirm the relevance of the participation of medical students in the extracurricular activities offered by the academic course, based on the principles of the university tripod: teaching, research and extension. This experience report has a descriptive and qualitative character. For its elaboration, 4 main activities were chosen, among those that were experienced by students of the Academic League of Clinical Medicine (Laclimed) during the academic period of the year 2023. The activities described involve fortnightly meetings, actions with the community, academic event and additional training. It was concluded that the existence of Academic Leagues contributes to the extracurricular training of medical students, by complementing the university workload, as it promotes the development of the hidden curriculum.
 
Keywords: medical clinic; academic league; health education; experience report; medical students.
Convective heat transfer of hybrid nanofluid flow in a cavity having vertical wavy sides
Authors: Al Kalbani Khamis , Uddin M. J.
Published: February 2025

Future hydraulic thermal substances made of hybrid nanofluids have a lot of potentials to fulfill the strict applied thermal energy management specifications of cutting-edge heat flux tricks. Due to synergistic thermal effects and general hydrothermal characteristics, it is necessary to examine the enhanced heat-transfer properties of nanofluids based on hybrid nanomaterials in various advances for the thermal management of machines with advanced heat flux. In a variety of corrugated casings filled with water and a  hybrid nanofluid, the effects of a horizontal magnetic field on natural convection heat transfer have been studied. Finite element techniques (FEM) have been employed to solve the generated dimensionless partial differential equations of the imposed nanofluids. On three distinct wave-shaped heated walls, the streamlines, heat flow, and average Nusselt number for the base fluid and the hybrid nanofluids were plotted and examined. The outcome demonstrates how the device's undulating walls and magnetic field strength have a major impact on heat transfer and heat flow.
Effect of Inclined MHD Peristaltic Transport for non-Newtonian model in a Non-Uniform Channel Through Porous Medium As: HTF
Authors: Ridha Safa Riyadh , Solagh Hussam Numan
Published: February 2025

The current work aims to study the effect of an inclined magnetohydro dynamics peristaltic transport of a non-Newtonian hyperbolic tangent fluid in a non-uniform channel via porous medium. The nonlinear governing equations regarding hyperbolic tangent fluid have been studied and solved analytically with the use of a regular perturbation approach under considerations of a long wavelength as well as low Reynolds number. All computational results are also discussed graphically using the MATHEMATICA program. The mathematical expressions for axial velocity and stream functions have been derived analytically. Different physical parameters have been shown graphically and discussed  it's effect. It is established that increasing the Hartmann number and the parameter of porosity will increase the velocity and the quantity of boluses.  While  the size of boluses decreases by increasing the magnetic field inclination angle. Moreover, Some mathematical and engineering aspects of non-Newtonian fluids are investigated  in the current analysis.
PENGARUH PENGUNGKAPAN CSR, EMISI KARBON DAN STRUKTUR MODAL TERHADAP NILAI PERUSAHAAN DENGAN PROFITABILITAS SEBAGAI VARIABEL MODERASI
Authors: Kifli Andi Zulkifli. A.F
Published: February 2025

This study aims to test and analyze the effect of CSR disclosure, carbon emission disclosure, capital structure on firm value with company profitability as a variable that moderates the relationship between CSR disclosure, carbon emission disclosure and capital structure on firm value. This type of research is quantitative research. This research was conducted at various industrial sector manufacturing companies listed on the Indonesia Stock Exchange (IDX) for the period 2018-2022. Research data in the form of annual reports and sustainability reports obtained from the official website of the Indonesia Stock Exchange and the official website of each company. The sample was 8 companies and 40 data. Sampling using purposive sampling method. The data were analyzed using the Moderated Regression Analysis (MRA) method processed with the Statistical Package for the Social Sciences (SPSS). The results showed that; 1) CSR disclosure has a positive and significant effect on firm value; 2) carbon emission disclosure has a positive and significant effect on firm value; 3) capital structure has a negative and significant effect on firm value; 4) profitability is able to moderate the relationship between CSR disclosure and firm value; 5) profitability is able to moderate the relationship between carbon emission disclosure and firm value; 6) profitability is not able to moderate the relationship between capital structure and firm value.
PENGARUH PENGUNGKAPAN TERKAIT KEBERLANJUTAN DAN IKLIM SESUAI IFRS S1 DAN S2 TERHADAP NILAI PERUSAHAAN
Authors: Dwiyandi Nando
Published: February 2025

Sustainability disclosure is entering a new era with the enhanced integration of sustainability and climate-related practices into corporate business and financial models through the newly established IFRS S1 and S2 Standards, which the International Sustainability Standards Board introduced in mid-2023 and take effect with implementation set for the 2024 reporting year. With focusing on companies listed in the ESG Quality 45 IDX KEHATI Index, this study will examines whether firm values can be influenced by sustainability and climate-related core content disclosures under these Standards. The research employs a quantitative model using Random Effects Model  with multiple linear regression equations. The results reveal that firm value is significant-negatively influenced by governance and strategy disclosures. Risk management disclosures can positively influence the firm value. However, firm value can not be influenced by metrics and targets disclosures. The research findings suggest that companies must strengthen their knowledge base and competencies in aligning these four core contents to achieve comprehensive and transparent sustainability disclosure.
Images of the trickster hero and the Picaro hero (based on the example of the story "The Fashionable Lawyer" by Taffy (N. A. Lokhvitskaya)
Authors: Paterikina Valentina Vasil'evna
Published: February 2025

The object of this research is the main character in the story "The Fashionable Lawyer" by Taffy (N. A. Lokhvitskaya), one of the brightest writers of the first half of the 20th century. The subject of the study is the image of the main character with the classic features of a trickster and a picaro. To characterize the features of these characters, Taffy's short story "The Fashionable Lawyer" was chosen, in which, in a modern situation, a hero is shown combining the features of a troublemaker, a merry man, a rascal. The shift from accusatory social satire to political satire at the turn of the 19th and 20th centuries did not affect the elegiac mood of N. A. Lokhvitskaya's stories, which did not denounce or castigate modern society. The non-classical character in Taffy's story is investigated, with transitions from established mythological characteristics to a mixture of features. Historical, biographical and deductive research methods are chosen. The historical and biographical method contributed to a retrospective analysis of the socio-cultural situation of the Russian space at the turn of the 19th century. Using the deductive method, from the general manifestation of the comic in Taffy's work to a specific character in her story "The Fashionable Lawyer", the character of the images of the trickster hero and the Picaro hero is considered. The novelty of the study lies in analyzing the traits of the hero of this story with conclusions about the partial coincidence of the character's character with the classic characteristics of the trickster and picaro. The distinguishing feature from the classic characters of the hero of the lawyer's story lies in the sincerity of his actions without realizing the tragic finale. Another vector of the novelty of this study is that N. A. Lokhvitskaya, long before the manifestation of postmodern features in Russian literature, predicted its markers in the tragicomedy of the situation, reflecting it in this story. The result of the study is expressed in the discovery of the features of the trickster hero and the picaro hero in the actions of the main character, with a shift in their classical functions. The results of this study are applicable to the analysis of N. A. Lokhvitskaya's work by both cultural scientists and literary critics. The conclusion is drawn about the tragedy of the comic and the tragedy of the comic through the main character's misunderstanding of responsibility for his actions.
La implantación de la Hacienda Real en el archipiélago canario. Una introducción a sus rentas y gestores (s. XV-primera mitad del XVI
Authors:   Universidad de La Laguna (España), Bello León Juan Manuel
Published: February 2025

This work aims to synthesize how the fiscal regime that had evolved in the Kingdom of Castile since at least the 13th century was implemented in the Canary Islands. Although the islands benefited from similar situations to other territories incorporated into the Crown during the late Middle Ages, the archipelago enjoyed certain circumstances that set it apart from other regions. Lower custom tariffs, fewer taxes, and a rapid increase in revenue characterized a fiscal administration carried out by small and large leaseholders alike. The work is complemented by tables and graphs that enhance our understanding of the fiscal system developed in the Islands between the late 15th and early decades of the 16th century.
Las pinturas arquitectónicas de Santa María de la Oliva de Lebrija en el tránsito de la Edad Media a la Moderna
Authors:   Universidad de Sevilla (España), Sáenz Rodríguez Álvaro
Published: February 2025

An important construction work was carried out in the Church of Santa María de la Oliva in Lebrija (Seville) between 1475 and 1521. This intervention added cloisters and a new apse to the building, though the apse was later transformed into its current form. At this juncture, an ambitious set of architectural paintings was deployed inside the Church, a set which is poorly preserved but richly documented by unpublished documents. The analysis of both sources will allow for the retrieval of the original temple’s image, as well as the recreation of the practice of fresco painters and gilders in the Kingdom of Seville. Even though these professionals followed the Hispano-Muslim artistic principles, they were receptive to incorporating late Gothic and early Renaissance repertoires.
Unexpected internal carotid artery injury during endoscopic transsphenoidal surgery
Authors: Sugiyama Natsuki , Tsutsumi Satoshi , Hashizume Akane , Murofushi Keisuke , Ueno Hideaki , Ishii Hisato
Published: February 2025

Background

Internal carotid artery (ICA) injury is a rare but severe complication of transsphenoidal surgery.

Case Description

A 69-year-old woman presented with progressive visual disturbance secondary to pituitary adenoma. The patient underwent subtotal tumor resection through endoscopic transsphenoidal surgery. The residual tumor in the cavernous sinus gradually enlarged over the next 3 years. During a second surgical intervention, an inadvertent scratch, with the worn-out tip of the micro-suction device, on the partially calcified medial wall of the C4 segment resulted in ICA rupture, leading to uncontrollable hemorrhage. After provisional hemostasis, the patient was transported to the angiography suite, where an irregularly shaped leak of contrast on the medial aspect of C4. A stent-assisted coil embolization was successfully performed, resulting in complete aneurysm isolation. The patient underwent revisional surgery on postoperative day (POD) 14, in which the coils exposed from the ICA laceration were covered with fascia lata, muscle, and surgical glue. After a lumboperitoneal shunt placement for progressive hydrocephalus, the patient was discharged on POD 82 without focal neurological deficits.

Conclusion

During transsphenoidal surgery, ICA injury can result from inadvertent manipulation using a micro-suction device. Careful manipulation and conservative resection followed by stereotactic radiosurgery may be a valid strategy for managing pituitary adenomas invading the cavernous sinus.
Posterior endoscopic cervical discectomy with partial pediculotomy for management of highly down-migrated cervical disc herniation: A case report
Authors: Ishibashi Katsuhiko , Yanagisawa Kazuyoshi , Tominaga Ryoji , Inomata Yasushi , Takebayashi Kento , Mizutani Takashi , Iwai Hiroki , Koga Hisashi
Published: February 2025

Background

Highly migrated cervical disc herniations are rare, and the optimal surgical approach remains uncertain. When located in the median or paramedian position, anterior cervical discectomy and fusion or anterior cervical corpectomy and fusion are preferentially selected, whereas posterior approaches are often considered for cases with radiculopathy.

Case Description

A 40-year-old woman presented with right C6 radicular symptoms without any specific triggering event. She initially experienced symptom relief through medication and an ultrasound-guided nerve block 4 years previously. The symptoms recurred 2 months before presentation and did not improve with conservative treatment. Magnetic resonance imaging revealed a paramedian herniation on the right side, migrating downward from the C5/6-disc level to the inferior border of the pedicle. Posterior endoscopic cervical discectomy (PECD) with partial pediculotomy was performed under general anesthesia with transcranial motor-evoked potential monitoring. The operative time was 56 min. The patient experienced immediate symptom relief, mobilized 3 h postoperatively, and was discharged the following day.

Conclusion

PECD with partial pediculotomy is a minimally invasive and effective option for treating highly down-migrated cervical disc herniation, offering reduced tissue disruption, faster recovery, and excellent clinical outcomes.
Borassus akeassii among the Turka. The uncertain future of a cultivated palm in southwestern Burkina Faso
Authors: Béné Ali , Fournier Anne , Devineau Jean-Louis , Nacro Hassan Bismarck
Published: February 2025

Description of the subject. Borassus akeassii Bayton, Ouédr. & Guinko is a multi-purpose species cultivated by various ethnic groups in southwestern Burkina Faso. These palm’s populations are undergoing significant transformations due to human activities. Objectives. This study aims to explore the structural characteristics and population dynamics of the palm tree, B. akeassii, in southwestern Burkina Faso, particularly in the Turka region. Method. The study is based on ethnographic surveys conducted among local populations, combined with ecological data. Results. The results highlight a predominance of juvenile palms, a balanced sex ratio among adult palms, generally satisfactory palm population health, and low mortality among adult palms due to controlled exploitation. Palm stands are currently affected by profound socio-economic changes. This has results in a loss of the social and economic value of the palm tree and the abandonment of traditional practices. Consequently, the abundance and condition of palm stands have deteriorated. Conclusions. The decisive factor in the dynamics of the palm stands appears to be the decrease in the social and economic profitability of the plant. The ancestral values and connections between B. akeassii palm and the local populations are currently being deconstructed. Borassus akeassii being cultivated in the region, the local population’s lack of interest in this plant and its products will lead to its replacement by other crops in areas reserved for agricultural activities.