bluuebunny/crossref_metadata_2025 huggingface dataset:
Distribution and Conduct of Clinical Trials Involving Music Therapy: Registered Clinical Trials in the Last 15 Years
Authors:   Department of Health Policy and Technology Assessment, National Institute of Public Health, Wako, Saitama 351-0197, Japan, Yukawa Keiko , Fuji Hitoshi ,   Department of Health Policy and Technology Assessment, National Institute of Public Health, Wako, Saitama 351-0197, Japan, Sato Hajime ,   Department of Health Policy and Technology Assessment, National Institute of Public Health, Wako, Saitama 351-0197, Japan
Published: February 2022

Objective: This study aimed to conduct an evaluation of music therapy clinical trials worldwide, to understand what trials have been conducted and to show the chronological changes. Additionally, we sought to clarify issues related to providing clinical trial registration information. Methods: We searched the International Clinical Trials Registry Platform (ICTRP) database for “music therapy,” and identified the disease target for each article found. Results: A total of 150 clinical trial studies were found in the ICTRP using the term “music therapy.” In these trials, music therapy was used for improvement of social functioning in schizophrenia and/or serious mental disorders, anxiety and depressive symptoms, and cancer symptoms. Twenty-five clinical trials were actively recruiting. Sixteen of the 25 trials were registered in the United States at ClinicalTrials.gov, of which 9 trials were conducted in the US. Seven trials were conducted in other countries such as Spain, Taiwan, and China. Conclusion: A search for music therapy clinical trials retrieved 150 trials from the ICTRP, and the number of clinical trial registrations has increased yearly. Music therapy is widely used in patients with various diseases, including Alzheimer’s disease, anxiety, and arthritic pain and has the potential to improve certain disease outcomes, but there is not enough evidence to substantiate its efficacy. It is important to enlighten researchers and pharmaceutical companies on the proper management of the quality of such clinical trial information, as this is an important issue.
Role of Bactiguard Infection Technology in Preventing Catheter-Associated Urinary Tract Infections
Authors:   Department of Plastic Surgery, JIPMER, Pondicherry 605006, India, Koliyath Shijina , Chittoria Ravi K. ,   Department of Plastic Surgery and Telemedicine, JIPMER, Pondicherry 605006, India, Aggarwal Abhinav ,   Department of Plastic Surgery and Telemedicine, JIPMER, Pondicherry 605006, India, Gupta Saurabh ,   Department of Plastic Surgery, JIPMER, Pondicherry 605006, India, Reddy Chirra L. ,   Department of Plastic Surgery, JIPMER, Pondicherry 605006, India, Mohan Padmalakshmi B. ,   Department of Plastic Surgery, JIPMER, Pondicherry 605006, India, Pathan Imran ,   Department of Plastic Surgery, JIPMER, Pondicherry 605006, India
Published: February 2022

To study the role of bactiguard infection technology (BIP) in preventing Catheter-associated urinary tract infections. This study was conducted in a tertiary care centre in the Department of Plastic Surgery, JIPMER, Pondicherry, India in the month of August 2019. The study subject was a 55-year-old gentleman with Fournier’s gangrene and type 2 diabetes mellitus (DM). The Foley’s catheter with BIP technology was used and its role in preventing urinary tract infections (UTI) was studied over a period of 10-days. During the period of the catheter use in our subject, patient did not develop features of urinary tract infections. BIP technology is claimed to be effective in preventing Catheter-associated urinary tract infections but further studies in more individuals is required to validate the same.
How a Network Came Together to Manage a Large Research Program During the Pandemic
Authors:   Office of Research Administration, Hackensack Meridian Health, 40 Prospect St, Hackensack, NJ 07601, USA, Friedman Tamara , Paleoudis Elli G. ,   Office of Research Administration, Hackensack Meridian Health, 40 Prospect St, Hackensack, NJ 07601, USA, Freed Avery ,   Office of Research Administration, Hackensack Meridian Health, 40 Prospect St, Hackensack, NJ 07601, USA, Adler Susan ,   Office of Research Administration, Hackensack Meridian Health, 40 Prospect St, Hackensack, NJ 07601, USA, Fittizzi Cheryl ,   Office of Research Administration, Hackensack Meridian Health, 40 Prospect St, Hackensack, NJ 07601, USA,   Office of Research Administration, Hackensack Meridian Health, 40 Prospect St, Hackensack, NJ 07601, USA and Hackensack Meridian Health School of Medicine, 340 Kingsland St Ste 123, Nutley, NJ 07110, USA
Published: February 2022

Hackensack Meridian Health, a large New Jersey network comprised of 17 hospitals, a medical school, and 200 ambulatory care centers, executes a large research program with approximately 1000 active human subjects studies. With the arrival of the coronavirus disease-2019 (COVID-19) pandemic, the Office of Research Administration was confronted with a series of challenges. These included minimizing face-to-face contact among research participants and staff, allocating limited resources to handle the influx of COVID-19 related proposals, providing human subjects protection training to the physicians and staff who were needed to run the clinical trials, adjusting bio-repository activities to meet the increased demand for samples, and disseminating all of the new regulatory and operational information to the thousands of researchers in the network. The network’s success in modifying its research program quickly and effectively to adapt to the changing landscape can be attributed, in large part, to the centralized nature of the research administration.
The Role of Negative Pressure Wound Therapy with Instillation and Dwell Time in the Preparation of Wound Bed
Authors:   Department of Plastic Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry 605006, India, Kerakad Nishad , Chittoria Ravi K. ,   Department of Plastic Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry 605006, India, Gupta Saurabh ,   Department of Plastic Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry 605006, India, Reddy Chirra L. ,   Department of Plastic Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry 605006, India, Mohan Padmalakshmi B. ,   Department of Plastic Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry 605006, India, Pathan Imran ,   Department of Plastic Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry 605006, India, Koliyath Shijina ,   Department of Plastic Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry 605006, India, Thomas Neljo ,   Department of Plastic Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry 605006, India
Published: February 2022

Introduction Although the negative pressure wound therapy (NPWT) is a time tested method of wound preparation, the role of NPWT with instillation and dwell time (NPWTi-d) in decreasing the downtime of wound preparation needs to be evaluated. Objective The objective of this study is assess the role of NPWTi-d in wound bed preparation. Materials and Methods This study was conducted in a tertiary care center, after getting informed consent and ethical clearance. NPWTi-d was done on a 36-years-old female with no known co-morbidities admitted with infected raw area over the right below knee amputation stump and exposed bone who was not responding well to conventional wound dressing. NPWT was applied with the help of sterile polyurethane sponge and two tubes. The antimicrobial solution used was ionic silver solution, just enough to wet the sponge completely and up to the point when the transparent occlusive covering begins to lift. Negative pressure was applied at 125 mmHg. The wound was bathed with ionic silver solution and it was allowed to stay in the wound for 10-minutes, after every 2-hours of negative pressure application. This was continued for 1-week. The dressing was opened at the end of 1-week, wound irrigated with normal saline, exudate swabs for culture taken and debrided, following which fresh NPWTi-d was applied. This was repeated for the next 3-weeks. Result By the end of third week, the wound became clean, fully covered with healthy granulation and the wound bed was ready to undergo the definitive wound cover procedure.
Role of Low-Level Laser Therapy as an Adjunct in the Management of Diabetic Ulcer
Authors:   Department of Plastic Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry 605006, India, Koliyath Shijina , Chittoria Ravi K. ,   Department of Plastic Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry 605006, India, Reddy Chirra L. ,   Department of Plastic Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry 605006, India, Mohan Padmalakshmi B. ,   Department of Plastic Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry 605006, India, Pathan Imran ,   Department of Plastic Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry 605006, India, Thomas Neljo ,   Department of Plastic Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry 605006, India, Kerakada Nishad ,   Department of Plastic Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry 605006, India
Published: February 2022

Diabetes mellitus (DM) is a chronic debilitating condition affecting people worldwide and diabetic foot ulcers are also a common problem. The treatment of diabetic ulcers requires a multimodal approach. Adjuvant low-level laser therapy (LLLT) may be useful in lesions with protracted healing course but the evidence is still limited. In this study, we share our experience regarding the use of low-level laser therapy as an adjuvant treatment modality in a patient with diabetic foot ulcer.
Leading Ebola Vaccine Candidates
Authors:   The Jenner Institute, University of Oxford, Oxford, OX3 7DQ, UK, Pavot Vincent
Published: February 2022

The ongoing outbreak of Ebola Virus Disease (EVD) in West Africa is the largest outbreak ever recorded with a total number of 28,602 confirmed, probable, or suspected cases in Guinea, Liberia, and Sierra Leone, including 11,301 reported deaths since December 2013 (as of January 17, 2016).1 A meeting convened by the World Health Organization (WHO) in September, 2014, concluded that an urgent unmet need exists for efficacy and safety testing of the EVD vaccine candidates and that clinical trials should be expedited. These vaccines could be used both in an outbreak setting and to provide long-term protection in populations at risk of sporadic outbreaks.
Innovations in Microbial Biodiscovery, Targeting Silent Metabolism and New Chemical Diversity
Authors:   Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia, Khalil Zeinab G. , Capon Robert J. ,   The University of Queensland Diamantina Institute, The University of Queensland, Brisbane, QLD 4102, Australia
Published: February 2022

It is quite evident that microbial (bacteria or fungi) crude extracts contain several important bioactive compounds and some have already shown their therapeutic activity. Unfortunately, most of the compounds have not properly been evaluated for the exploration of new lead molecule. Moreover, some of the mechanisms of actions of few bioactive compounds have not been identified so far. Hence, extensive research is required to find out the activity of compounds in the microbial crude extracts and to exploit their therapeutic potential to unlock silent secondary metabolites. Therefore, this review article raise the importance of activating microbial secondary metabolites noting the need for new tools to access the full microbial genome
Fluorinated Lipids Conjugated to Peptide Antigens do not Induce Immune Responses Against Cervical Cancer
Authors:   School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia, Hussein Waleed M. , Mukaida Saori ,   Helwan University, Faculty of Pharmacy, Pharmaceutical Organic Chemistry Department, Ein Helwan, Egypt, Liu Tzu-Yu ,   School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia, Toth Istvan ,   School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia, Helwan University, Faculty of Pharmacy, Pharmaceutical Organic Chemistry Department, Ein Helwan, Egypt and School of Pharmacy, The University of Queensland, Brisbane, QLD 4102, Australia
Published: February 2022

Background: Despite the high safety profile of peptide-based vaccines over conventional counterparts, the inability of small peptides to produce a strong immune response represents the main obstacle for the development of these types of vaccines. Introducing a self-adjuvanting moiety such as fluorinated lipids can overcome this problem. We have recently demonstrated that fluorinated lipids can induce humoral immune responses against associated peptide antigen; however, the ability of these amphiphilic lipids to elicit a desired cellular immune response to eradicate tumor cells has not been yet investigated. Methods: An in vivo assay was employed to evaluate the ability of fluorinated lipopeptides to eradicate tumor in mouse model. In this study, the double conjugation technique was used to synthesise fluorinated and non-fluorinated lipids conjugated to two cytotoxic T-lymphocyte (CTL) peptide epitopes derived from the E6 and E7 proteins of human papilloma virus (HPV). Results: Mice implanted with TC-1 tumor cells and immunised with fluorinated lipopeptides did not mount a strong cellular immune response, thus did not eradicate the tumors. In contrast, 60% of mice immunised with the non-fluorinated lipopeptide cleared the TC-1 tumor. Conclusion: This result indicated that fluorinated lipids lack of the ability to stimulate a strong cellular immunity despite their ability to elicit significant humoral immune responses.
Aktives Büro im Hessischen Ministerium der Finanzen
Authors:   Hessisches Ministerium der Finanzen, Wiesbaden, Hohmann Michael , Klatt Stephanie ,   Hessisches Ministerium der Finanzen, Wiesbaden
Published: February 2022

Das Gesundheitsmanagement hat im Hessischen Ministerium der Finanzen (HMdF) einen hohen Stellenwert. Die Förderung von Aktivität im Büroalltag ist ein wesentlicher Bestandteil der behördlichen Gesundheitsförderung. Die in den Gebäuden des Ministeriums implementierte Arbeitswelt nach dem ActiveOffice®-Konzept bietet den Beschäftigten die Möglichkeit, Bewegung ohne zusätzlichen Zeitaufwand in die Büroprozesse zu integrieren.
Wiederherstellung der Arbeitsfähigkeit nach primärer Hüftendoprothetik
Authors:   Praxisklinik für Unfallchirurgie und Orthopädie Eisenach, Universitätsklinikum Jena, Klinik für Unfall-, Hand- und Wiederherstellungschirurgie, Spahn Gunter , Hubatschek Nils ,   Praxis für Orthopädie und orthopädische Chirurgie, Eisenach, Claaßen Thomas ,   Praxis für Orthopädie und orthopädische Chirurgie, Eisenach, Hofmann Gunther O. ,   Universitätsklinikum Jena, Klinik für Unfall-, Hand- und Wiederherstellungschirurgie, BG-Klinikum „Bergmannstrost“ Halle/Saale, Hartmann Bernd ,   ArbMedErgo, Beratung für Arbeitsmedizin, Arbeitsphysiologie und Ergonomie, Hamburg
Published: February 2022

Return to work after primary hip-replacement Objectives: The aim of the retrospective study was to determine the rate of restoration of capacity for work after primary hip prosthesis. Method: The study included a total of 56 patients (29 men and 27 women) at an average age of 55.2 (SD 6.6) years who underwent the implant of a unilateral hip joint prosthesis due to coxarthrosis. Results: Preoperatively, 49 (87.5 %) patients had a light (6.1 %), moderate (61.2 %) or heavy (37.7 %) workload. The remaining patients were considered to be looking for work. At the time of the operation, 67.9 % of patients were able to work, 12.5 % were incapacitated for less than 4 weeks, and the remaining patients were incapacitated for more than 4 weeks. Only 30.4 % of patients had no concomitant diseases or obesity. In 42 patients (75.0 %) the ability to work was restored after an average of 13.1 (SD 7.5; 4–48) weeks. Retirement within the first postoperative year occurred in 8.9 % of cases. Overall, 37.2 % of patients switched to easier physical work. The presence of an accompanying disease (p = 0.001), obesity with a BMI > 30 (p = 0.834) or the presence of concomitant morbid obesity (p = 0.411) showed no link in terms of restoring work ability. Overall, a very good result was achieved in 71.4 % of cases and a good result in 26.8 %. However, there was no link between gender, comorbidity or occupational rehabilitation. Conclusions: In the vast majority of patients, it is possible to achieve satisfactory to good professional rehabilitation after implanting a hip prosthesis. Occupational stress factors and social factors in the workplace play a role in rehabilitation. A smaller proportion of patients currently have to accept a reduced physical workload as a precautionary measure. There is a need for more information on probationary periods at work after a hip replacement; this must be systematically collected and linked to actual occupational stress. Keywords: hip osteoarthritis – replacement – return to work
Die Geschichte des Schlesischen Schlammfiebers
Authors:   Institut für Geschichte der Medizin, Charité – Universitätsmedizin Berlin, Jüttemann Andreas
Published: February 2022

The history of Silesian slime fever Slime fever is a bacterial infection that particularly affected agricultural workers in Silesia between 1880 and 1940. The town of Ratibor (Racibórz in Polish) in Upper Silesia was a centre of the outbreaks. It was particularly hard hit by the flood disasters on the Oder in 1891, 1926 and 1939. Large outbreaks also occurred on a regular basis in Bavaria, where the disease was known as harvest fever or field fever. Leptospira were clearly identified as pathogens for all manifestations in 1927. Further research showed that mice and rats were the main cause of the spread of bacteria. Apart from harvest helpers, slime fever primarily affected canal workers in towns or swimmers. Leptospirosis is a recognised occupational disease in agriculture today and is usually treated with antibiotics. Keywords: leptospirosis – spirochetes – slime fever – Silesia – Ratibor – history
Reconceptualizing opportunity construct: An answer to a theoretical dilemma through a systematic literature review
Authors:   University of Tehran, Yadolahi Farsi Jahangir , Arabiun Abolghasem ,   University of Tehran
Published: February 2022

After Shane’s seminal work in 2000 which highlighted the importance of entrepreneurial opportunities, the number of studies focusing on entrepreneurial opportunity increased rapidly. Different definitions of this concept were provided in the field, ranging from subjective to objective ones, which gave rise to a lack of consensus among researchers and this, in turn, was an obstacle that slowed down theorizing in entrepreneurship. Taking into account the past trends in management sciences, it seems to be the right moment to re-conceptualize the core construct of opportunity. The major critique of existing definitions is their operationalization. To provide a better operationalization, the present study aimed to offer a more accurate conceptual definition. To this end, the study first examined current debates on opportunity, which revealed the major problem causing the debates. Then, through a systematic literature review, from among more than seven thousand documents in the Scopus database containing opportunity keywords, 74 papers were selected following different phases of filtration. The papers were analyzed in detail to extract different constructs. Then, using the framework of Hansen et al, they were classified along six dimensions. The concepts under each dimension were examined to finally provide a bigger picture of the construct of opportunity and offer a re-conceptualization. The results of this study highlight the gaps for future research and pave the ground for other systematic literature reviews in the field.
Sürdürülebilir insan kaynağı yönetimi: Belirsiz fayda fonksiyonlu doğrusal-olmayan atama programı ile çalışan memnuniyetinin arttırılması
Authors: TURAN Fikret Korhan , CORUH Gül
Published: February 2022

Kurumların sahip olduğu en önemli kaynak şüphesiz
insandır ve insan kaynağını en doğru şekilde kullanabilmeleri zaman ve paradan
tasarruf etmelerini sağlar. İnsan kaynağı yönetiminin en önemli adımlarından
biri ise iş-personel eşleştirme sürecidir. Bu süreçte başarı için işe
yerleştirilecek adayın teknik yeterliliğinin yanı sıra görev alacağı pozisyon
ile ilgili memnuniyet ve beklentilerini de düşünmek gerekir. Bu bağlamda,
sunulan çalışma ile güncel bir yaklaşım olan sürdürülebilir insan kaynağı
yönetimi altında, çalışan memnuniyetini arttıracak bir iş-personel atama karar
destek modelinin geliştirilmesi amaçlanmıştır. Geliştirilen karar destek
modelinde çalışan memnuniyetini ölçmede fayda teorisi ve fonksiyonlarından
yararlanılırken, optimal iş-personel eşleştirmesini gerçekleştirmede belirsiz
fayda fonksiyonlu doğrusal-olmayan atama programı kullanılmıştır. Geliştirilen
karar destek modeli ile hem çalışan memnuniyetinin ekonomik, sosyal ve çevresel
faktörlere göre çoğunlukla doğrusal-olmayan bir şekilde değişiklik göstermesi
durumu, hem de çalışan memnuniyetinde olabilecek belirsizlikler aynı anda
hesaba katılarak, önceki modellerden daha gerçekçi bir yaklaşım sunulmuştur.
Geliştirilen karar destek modelinin uygulaması kurgusal bir örnek üzerinden
gösterilmiş, Monte Carlo benzetimi kullanılarak elde edilen sonuçlar duyarlılık
analizi ile istatistiksel bağımsızlık ve bağımlılık durumları altında
incelenmiştir. Bu sayede çalışmanın özgün tarafı detaylı olarak irdelenmiştir.
QStE420TM çelik malzemelerin farklı bazik elektrodlar kullanılarak örtülü elektrodla ark kaynak yöntemiyle kaynaklanabilirliğinin araştırılması
Authors: HARMAN Mustafa , ADA Hakan , ÇETİNKAYA Cemil
Published: February 2022

Savunma sanayi, otomotiv sanayi gibi sektörlerde yaygın şekilde kullanılan ince taneli ve mikro alaşımlı yapıya sahip QSTE 420 TM kalitesinde imal edilmiş çelik sac plaka malzemeler, 3 farklı kimyasal kompozisyona sahip bazik tipte çubuk elektrod yardımıyla elektrik ark kaynak yöntemi kullanılarak ayrı ayrı birleştirilmiştir. Birbirinden farklı kimyasal kompozisyona sahip çubuk elektrodların belirli parametrelerde ergimesi sonrası oluşan kaynak bölgesi (ana malzeme, ısının tesiri altındaki bölge ve kaynak metali) üzerinde oluşan mekanik ve metalürjik etkiler; çekme, eğme, çentik - darbe, sertlik testleri ve makro grafik, mikro grafik muayeneler yapılarak incelenmiştir. Her bir elektrodla gerçekleştirilen kaynaklı birleştirmelere uygulanan testler sonucunda; seçilen bazik elektrodların, kaynaklı birleştirmelerin kendinden beklenen mekanik ve metalürjik özellikleri hangi oranda sağladığı irdelenmiş ve optimum sonuçlar yalnızca 3. deneyde elde edilmiştir.
Küçük bir veri merkezinin iklimlendirme ünitelerine yönelik baypas yönteminin enerji ve ekonomik analizi
Authors: ERDEN Hamza Salih , TÜRKMEN İsmail
Published: February 2022

Önceki optimizasyon çalışmaları sistem odası kliması (computer room air handling, CRAH) baypas (BP) yönteminin veri merkezlerindeki enerji tasarruf potansiyelini oda seviyesinde akış ağı modelleme ve soğutma altyapısı seviyesinde termodinamik modellemeyi harmanlayan indirgenmiş model yaklaşımı kullanmışlardır. Akış ağı modellerini barındıran termodinamik modeller farklı BP oranları için soğutma altyapı gücünü tahmin etmekte iyi bir iş çıkarmıştır. Ancak yapılan çalışmalar varsayımsal veri merkezleri ya da deneysel düzeneklerle ilgili olup yöntemin gerçek ve işler bir veri merkezinde yapılabilirliğine yönelik kayda değer bir çalışma bulunmamaktadır. Literatürdeki bir diğer eksiklik de yöntemin ekonomik gereksinimleridir. Bu çalışmada, literatürde önerilen indirgenmiş modelleme yaklaşımlarını kullanarak klima BP yöntemlerinin (itişli ve çekişli) çalışan bir veri merkezine uygulanabilirliği üzerine değerlendirmeler yapılmıştır. Çeşitli senaryoların enerji ve ekonomik analizi neticesinde klima BP yönteminin fizibilitesinin, tasarımın ihtiyaç duyduğu fan sayısına doğrudan bağlı olduğu sonucuna ulaşılmış ve çalışan bir veri merkezi için uygulama önerilerinde bulunulmuştur.
Nano kil parçacık ilavesinin bazalt elyaf takviyeli kompozit plakaların eksenel ve yanal burkulma özelliklerine etkisi
Authors: BULUT Mehmet , ÖZBEK Özkan , BOZKURT Ömer Yavuz , ERKLİĞ Ahmet
Published: February 2022

Mevcut araştırma, epoksi matris sistemine nano kil (NK) parçacıklarının dahil edilerek bazalt elyaf takviyeli kompozit plakaların burkulma özelliklerini geliştirmeyi amaçlamaktadır. Ağırlıkça farklı NK konsantrasyonları (% 0,0, 0,5, 1,0, 1,5, 2,0 ve 3,0) içeren bazalt elyaf takviyeli epoksi tabakalı kompozit plakalar, vakum destekli reçine transfer kalıplama yöntemi ile üretilmiş ve NK parçacıklarının burkulma özellikleri üzerindeki etkilerini belirlemek için numuneler eksenel ve yanal basma yüklemelerine tabi tutulmuştur. Ayrıca, NK parçacıklarının malzeme yapısı üzerindeki etkileri, burkulmuş numunelerin taramalı elektron mikroskobu (SEM) görüntüleri ile analiz edilerek incelenmiştir. Bazalt elyaf düz dokuma kumaşlar ile üretilen kompozit plakalarda bazalt takviyesinin elyaf hacim oranı %43 ± 1.0 olarak bulunmuştur. Sonuçlar, NK parçacık eklentisinin bazalt elyaf takviyeli kompozit plakaların hem eksenel hem de yanal burkulma davranışları üzerinde önemli etkilere sahip olduğunu göstermiştir. NK parçacığı içermeyen numuneler ile karşılaştırıldığında, numunelerin eksenel ve yanal kritik burkulma yükleri için elde edilen en yüksek iyileşmeler sırasıyla %48,10 ve %39,56 olarak ağırlıkça %1 NK parçacık eklentisinden elde edilmiştir. NK parçacık ilavesi oranının artması (ağırlıkça %1'in üzerinde) kritik burkulma yüklerinde azalmalara neden olmuştur. Bu durum, bazalt elyaf/epoksi ara yüzlerinde nano parçacıkların belli bölgelerde topaklanması ve pul pul dökülmeleri sonucunda olan zayıf ara yüzey bağlantısına atfedilmektedir. Elde edilen sonuçlara göre NK parçacık ilavesi uygulamasının bazalt elyaf takviyeli epoksi kompozitlerin yapısı ile uyumlu olduğu görülmüş ve yüksek burkulma direnci gerektiren uygulamalarda birlikte kullanılabileceğini kanıtlamıştır.
Al 6061 alaşımının işlenmesinde kesme derinliği ve kesici takım geometrisinin yüzey pürüzlülüğüne ve takım aşınma davranışına etkisi
Authors: PUL Muharrem , ÖZERKAN Hacı Bekir
Published: February 2022

İşlenebilirlik üzerine yapılan bu deneysel çalışmada, Al 6061 alüminyum alaşımının tornalanmasında, kesme derinliği ve farklı profildeki kesici takımların işlenen yüzeyin pürüzlülüğüne etkisi incelenmiştir. Bu amaçla, 0,4-0,8-1,6-2,4 mm kesme derinlikleri ve ISO kodları, SNMA 120408 KR 3210, KNUX 160405 R11, TNMG 160404, DCGT 11T308 ALU olan kesici takımlar kullanılmıştır. İşlenebilirlik deneylerinde, 0,2 mm/dev sabit ilerleme değeri ve 125 m/dak, 250 m/dak olmak üzere iki farklı kesme hızı değeri seçilmiştir. Deneyler sonucunda her kesici takım farklı yüzey pürüzlülük değerleri sergilemiş olup en düşük pürüzlülük değerleri SNMA 120408 KR kodlu kesici takım ile elde edilmiştir. Kesme derinliği değerlerinin azalmasıyla, genel olarak yüzeylerin pürüzlülük miktarları azalmıştır. Ancak, SNMA 120408 KR kodlu takımla yapılan işlemelerde tersi davranış gözlenmiş ve en yüksek pürüzlülük değeri 0,4 mm kesme derinliğinde elde edilmiştir. Kesme hızının değişimi ile ise yine kesici takım cinsine göre farklı yüzey pürüzlülük değerleri elde edilmiştir. Ancak kesme hızının yükselmesiyle, pürüzlülük değerlerinde beklenen azalma meydana gelmemiştir. DCGT kodlu takım, yüzey pürüzlülüğü bakımından diğer kesici takımlara göre üstünlük sağlayamamıştır. Fiyat performansı açısından değerlendirildiğinde, yine SNMA 120408 KR kodlu takımların seçilen diğer takımlara göre daha uygun ve optimum olduğu tespit edilmiştir.
Derin öğrenme kullanılarak nesnelerin interneti tabanlı mobil sürücü yorgunluk tespiti
Authors: ŞAFAK Emre , DOGRU İbrahim , BARIŞÇI Necaattin , TOKLU Sinan
Published: February 2022

Sürücü yorgunluk tespiti trafik kazalarını önlemek için önemli bir konudur. Şiddetli trafik kazalarının %40’ı yorgunluk nedeniyle yaşanmaktadır. Sürücü yorgunluk tespiti için çeşitli yöntemler kullanılmaktadır. Sürücü yorgunluk tespiti yöntemlerinden biri EEG ve ECG gibi fiziksel sinyallerin analiz edilmesine dayalı sürücü yorgunluk tespitidir. Bu yöntemde sürücülere doğrudan müdahale gerekmektedir. Bir başka sürücü yorgunluk tespiti yöntemi araç-sürücü etkileşimine dayalı sürücü yorgunluk tespitidir. Bu yöntemde sürücülerin gaza basma şiddeti, direksiyon tutuşu ve frene basma sıklığı gibi davranışlar analiz edilmektedir. Ancak bu davranışlar kişiden kişiye değiştiğinden genelleştirilebilmesi zordur. Yapılan çalışmada kullanılan ve son sürücü yorgunluk tespiti yöntemi görüntülerden sürücü yorgunluk tespitidir. Bu yöntem diğer iki yönteme göre maliyet ve kullanılabilirliğin yanında sürücüye müdahale gerekmediğinden daha avantajlıdır. Kameralar üzerinden gelen görüntüler analiz edilerek yorgunluk tespiti yapılabilmektedir. Görüntülerden sürücü yorgunluk tespiti çalışmaları için klasik görüntü işleme teknikleri ve derin öğrenme algoritmaları kullanılmaktadır. Son sürücü yorgunluk tespiti çalışmaları genellikle derin öğrenme ağı modellerini temel almaktadır. Bunun yanında yaygın kullanımın sağlanabilmesi için geliştirilecek modelin mobil cihazlar üzerinde çalışabilmesi gerekecektir. Yapılan çalışmada mobil cihazlarda sürücü yorgunluk tespiti için Evrişimsel Sinir Ağları kullanılmıştır. Modelin başarı oranını artırabilmek için önceden eğitilmiş model transfer öğrenme tekniğiyle tekrar kullanılmıştır. Geliştirilen model %95,65 başarı oranına ulaşarak daha önceki yapılan çalışmalardan daha iyi sonuç elde etmiştir.
[RETRACTED] Whole Leaf CBD Oil Reviews (Scam or Legit) Warning? & WholeLeaf CBD Square Gummies v1
Authors: Leaf CBD Oil Whole
Published: February 2022

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Whole Leaf CBD Oil Reviews (Scam or Legit) Warning? & WholeLeaf CBD Square Gummies
[RETRACTED] Green Lobster CBD Gummies Sale Amazon: UK, USA, Australia, South Africa, Canada, NZ (Ingredients Updates) v1
Authors: States United
Published: February 2022

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[RETRACTED] Lion HRT Amazon: UK, USA, Australia, South Africa, Canada, NZ (Ingredients Updates) v1
Authors: States United
Published: February 2022

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[RETRACTED] Golden Revive Plus Amazon: UK, USA, Australia, South Africa, Canada, NZ (Ingredients Updates) v1
Authors: States United
Published: February 2022

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[RETRACTED] KeraGenis Amazon: UK, USA, Australia, South Africa, Canada, NZ (Ingredients Updates) v1
Authors: States United
Published: February 2022

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[RETRACTED] Triple Tinnitus Formula Amazon: UK, USA, Australia, South Africa, Canada, NZ (Ingredients Updates) v1
Authors: States United
Published: February 2022

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[RETRACTED] Triple Metabo-Greens Amazon: UK, USA, Australia, South Africa, Canada, NZ (Ingredients Updates) v1
Authors: States United
Published: February 2022

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[RETRACTED] Triple Keto Amazon: UK, USA, Australia, South Africa, Canada, NZ (Ingredients Updates) v1
Authors: States United
Published: February 2022

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[RETRACTED] WholeLeaf CBD Square Gummies - All the benefits of Cannabis, without the "high" v1
Authors: not provided rying
Published: February 2022

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[RETRACTED] TestoUltra Amazon: UK, USA, Australia, South Africa, Canada, NZ (Ingredients Updates) v1
Authors: States United
Published: February 2022

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[RETRACTED] Dentitox Pro Amazon: UK, USA, Australia, South Africa, Canada, NZ (Ingredients Updates) v1
Authors: States United
Published: February 2022

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[RETRACTED] Whole Leaf CBD Gummies - Experience A Pain-Free, Active & Fuller Lifestyle v1
Authors: not provided rehnurahunas
Published: February 2022

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Readiness for autonomous English language learning: The case of Indonesian undergraduate students
Authors: Daflizar Daflizar , Petraki Eleni
Published: February 2022

The purpose of this study was threefold: (1) to investigate how Indonesian undergraduate students perceive their teachers’ and their responsibilities in English language learning; (2) to investigate how the students perceive their abilities related to autonomous English language learning; (3) to examine if there are differences in the students’ perceptions of their responsibilities and abilities concerning gender and majors of study. The study employed a mixed-methods research approach with a sequential explanatory design and recruited 402 participants in the quantitative phase and 30 participants in the qualitative phase. The data were collected through questionnaires and semi-structured interviews. The findings showed that the majority of students deemed the teacher to be the one in charge of their learning despite their positive perceptions of their abilities. No significant difference was found between males and females in their perceptions of responsibilities and abilities. Regarding majors of study, no significant difference was found between English major students and non-English majors in their perceptions of their abilities; however, there was a significant difference between the groups’ perceptions of their responsibilities. The research advocates the need for awareness-raising on the benefits of learner autonomy and appropriate teacher training for the Indonesian context.
Conceptual metaphors in North African French-speaking news discourse about COVID-19
Authors: Lahlou Hicham , Rahim Hajar Abdul
Published: February 2022

Conceptual metaphors have received much attention in research on discourse about infectious diseases in recent years. Most studies found that conceptual metaphors of war dominate media discourse about disease. Similarly, a great deal of research has been undertaken on the new coronavirus, i.e., COVID-19, especially in the English news discourse as opposed to other languages. The present study, in contrast, analyses the conceptual metaphors used in COVID-19 discourse in French-language newspapers. The study explored the linguistic metaphors used in COVID-19 discourse in these newspapers and conceptual metaphors that underlie and motivate them, using a conceptual metaphor theory framework (CMT). Therefore, two North African French-language newspapers, namely Libération, published in Morocco, and La Presse de Tunisie, published in Tunisia, formed the corpus of the current study. The results showed that the most frequent framing of COVID-19 was in terms of WAR, followed by DISASTER and KILLER, respectively.
Indonesian TV anchors’ final -k sound shift: The nature and the cause
Authors: Irnanda Septhia , Yoestara Marisa , Ismawirna Ismawirna , Faisal Faisal
Published: February 2022

This study aimed, firstly, to observe the phonological change of the Standard Indonesian (SI), particularly the final-k syllabic pronunciation used in the journalistic videos aired between 1980 – 2019. Secondly, the study investigated the nature of the sound change by taking into account the theories of Lexical Diffusion. Lastly, the plausibly cause of the sound change was figured out, considering the sociolinguistic factors; orthographic re-regulation, post-colonial language policy, borrowing, and contacts. Methodologically, it is a diachronic study using a set of television news videos as the main source of data. A battery of findings from other related studies was employed to support the discussion on the nature and the reason for the sound change. The results show that the phonological shift of coda /ʔ/ ~ /k/ happened to most final -k syllabic words across the periods observed, but with varying degrees of rapidity, where the high-frequency words tend to be more sustained. The results also indicated that phonological shift of coda /ʔ/ ~ /k/ that occurred in the Indonesian TV-broadcast language was transferred from the Jakartan dialect, although some evidence of the 1972’s alphabetic writing system reformation also plays a considerable role in the TV News readers’ final -k sound shift.
Children’s humor development: A case of Indonesian children
Authors: Sahayu Wening , Triyono Sulis , Kurniawan Eri , Baginda Putrasulung , Tema Nurul Huda Gus
Published: February 2022

Humor has been characterized as an index of children’s language development and cognitive performance. While research on this area has been abound cross linguistically, specific inquiry on children’s humor development in the Indonesian context remains scant. Occupying this lacuna, this research sought to examine kinds of humor acquired by the children in early childhood by invoking McGhee’s humor developmental stages. Embracing a descriptive qualitative method, the study involved eleven Indonesian-speaking children in Yogyakarta aged around 1 to 5 years old, where the data were assembled primarily through direct naturalistic observations. The children’s spontaneous humor production was recorded as they were interacting with their peers and/or their parents in their homes and neighborhoods. The findings revealed that the children could perceive and produce nonverbal and verbal humor, confirming existing literature. As they grow, certain patterns of humor also emerge, indicative of their cognitive and social development. More research is necessary to better understand how children of different linguistic and cultural backgrounds understand, respond to or initiate a humorous situation.
Parental Perspectives on Their Grade 4 Children with Reading and Writing Difficulties in Mainstream Government Schools in Mauritius
Authors: Veerabudren Sattiavany , Kritzinger Alta , Graham Marien , Geertsema Salomé , Roux Mia Le
Published: February 2022

Reading and writing difficulties (RWD) in learners pose significant challenges not just for children but also for parents. While there is limited support available for children with RWD and their parents in Mauritian schools, research may reveal areas of parental need that speech-language therapists may address. The aim was to determine parents’ perspectives regarding their Grade 4 children with RWD in mainstream government schools in Mauritius. Teachers identified children with RWD with the Screening Tool for Learning Disorder, and parents were requested to participate in the study. Sixty-seven parents completed a questionnaire investigating their perspectives on the symptoms and causes of their child’s RWD and the ways in which they assist their child. The screening tool differentiated between children at risk of specific learning disorder (SLD) and children who indicated clear symptoms of SLD. The results of the tool did not correspond closely with the participants’ satisfaction with their child’s academic performance. The majority of participants could, however, identify RWD in their children when descriptions were given. Parents mostly cited laziness as the main cause of their child’s RWD. The results showed that participants had limited information about the causes and symptoms of RWD and SLD. There is a lack of awareness about the role of speech-language therapists in the intervention of RWD. There are limited resources and support for children with RWD, despite an inclusive education policy in Mauritius. Speech-language therapists and teachers should collaborate to support children with RWD and their parents using inclusive education strategies.
Colonization of pregnant women with group B streptococcus: current view at the problem
Authors: Olenev A. S. , Konopliannikov A. G. , Songolova E. N. , Stetsyuk O. V.
Published: February 2022

The relevance of the problem of group B streptococcus (GBS) in obstetric practice casts no doubt. Attracting the close attention of leading experts, introducing new solutions and based on practical experience gained, it is still not possible to prevent all cases of neonatal infections associated with GBS. The review article demonstrates the current view of the problem. According to the literature, African-American race in combination with sexually transmitted infections are predisposing risk factors for GBS colonization. A direct relationship between obesity and the percentage of GBS carriers was revealed. GBS-colonized primigravidas have a 50 % increased chance of detecting the pathogen in subsequent pregnancies. Absolute factors for massive GBS colonization of the birth tract include GBS-associated asymptomatic bacteriuria and a history of GBS-colonized children. It is assumed that such virulence factors as hemolytic pigment and hyaluronidase contribute to the GBS pathogenic potential. The protective function in the immune system is performed by Kaschenko–Gofbauer cells, but their role is ambiguous. Early neonatal GBS infection realized in 90 % of newborns that manifested by sepsis, pneumonia and purulent meningitis. Implemented measures to prevent early neonatal GBS infection have a number of disadvantages. False-negative results of culture screening for GBS antigen at gestational age of 35–37 weeks increase a risk of vertical transmission, whereas false-positive results underlie a reason for prescribing irrational intranatal antibiotic prophylaxis. Moreover, antenatal GBS microbiological screening and antibiotic prophylaxis at birth do not prevent the risks of late-onset neonatal GBS infection.
Experimental Study on Unidirectional Pedestrian Descending and Ascending Stair With a Fixed Obstacle
Authors: Shi Dongdong , Yang Meicheng , Chen Juan , Ma Jian
Published: February 2022

Staircase is one of the most essential vertical passageway for pedestrians’ timely evacuation, and has distinct constraint on pedestrians’ movement characteristics when compared with corridors and hallways. During evacuation, temporary obstacles can be observed on stairs, e.g., the abruptly stopped pedestrians or the luggage of pedestrians discarded. It is noticed that studies on the effect of obstacles on pedestrian dynamics mainly focused on planar locomotion, the impact of obstacle on the movement characteristics of pedestrians ascending and descending stairs have not been systematically studied yet. Therefore, in this study, a series of unidirectional pedestrian avoid obstacle movement experiments on staircase under controlled laboratory conditions were performed. The avoidance characteristic of pedestrians is observed from trajectory diagram. Target drift angle towards left and right is further calculated and analyzed. The study found that target drift angle curve occur to relatively large fluctuations to avoid obstacle of a pedestrian rather than not appear to obvious variety to avoid obstacle of a suitcase. Meanwhile, the change trend of target drift angle towards left and right for scenarios S3 and S4 is consistent with results of scenarios S1 and S2. Then, an interesting discovery indicates that the pedestrians will accelerate after passing obstacles whether it is ascending process or descending process. Finally, the obstacle of a pedestrian will accelerate the movement efficiency in ascending process from results of flow rates, but the result is contrary to that of descending process. The systematic experimental data can not only be used for the verification and validation of pedestrian models but also can provide a benchmark for the design of related facilities aiming at improving traffic efficiency.
Numerical Study of Bottleneck Flow with Varying Corridor Width and Motivation Using a Speed-Based Model
Authors: Rzezonka Jonas , Seyfried Armin , Hein Ben , Chraibi Mohcine , Schadschneider Andreas
Published: February 2022

In this study a simple speed-based model is employed to simulate an experiment of pedestrian bottleneck flow. The experiment revealed that the density near the bottleneck is influenced by the motivation of the pedestrians and the corridor width. In narrow corridors, distinct lanes are formed for pedestrians with low motivation. These lanes can disappear when the pedestrians have a high motivation to reach their target. We show that a speed-based model is - despite its relative simplicity- capable to reproduce the observed phenomena to a high degree.
The effectiveness of correction methods for isthmic-cervical insufficiency: cohort study results
Authors: Pesegova Svetlana V. , Timokhina Elena V. , Strizhakov Aleksandr N.
Published: February 2022

AIM: To assess the pregnancy outcomes in patients with isthmic-cervical insufficiency (ICN) and the effectiveness of modern methods of correction, namely cervical cerclage, obstetric discharge pessary, and progesterone preparations.
MATERIALS AND METHODS: The retrospective analysis included 184 females with ICN, who were divided into three groups based on ICN correction methods: 1st group consisted of 82 (44.6%) females who were corrected by cervical cerclage; 2nd group with 67 (36.4%) females by obstetric pessary; and 3rd group with 35 (19.0%) females by progesterone therapy with ICN sign appearance.
RESULTS: According to the obtained data, every second patient (53.3%) in our study had risk factors for ICN development due to the mechanical expansion of the cervical canal in cervical anamnesis. In most cases, ICN was diagnosed in 20 weeks and more, and the median period of correction was 21 [2022] weeks in 1st group, 24 [2226] weeks in 2nd group, and 22 [2022] weeks in 3rd group (p 0.001). The overall incidence of preterm birth (PTB) in 1st group was 48.8%, whereas 40.3% in 2nd group and 60% in 3rd group. The share of timely births accounted for 41.5% in 1st group, whereas 53.7% in 2nd group and 11.4% in 3rd group.
CONCLUSION: Correction of ICN with cervical cerclage and obstetric pessary showed similar effectiveness and allowed prolonged pregnancy to more favorable terms. The correction group with only progesterone preparations noted a high frequency of premature pregnancy termination since this group initially included females with a higher risk of PTB and adverse factors for further prolonged pregnancy.