bluuebunny/crossref_metadata_2025 huggingface dataset:
ASSOCIATION ANALYSIS OF PIOGLITAZONE EFFECTIVENESS IN TREATMENT OF NAFLD PATIENTS WITH OBESITY AND PPARG RS1801282 (PRO12ALA) GENOTYPE
Authors: Shypulin Vadym P. , Martynchuk Oleksandr A. , Rudenko Nikolai N. , Koliada Aleksandr K. , Tishchenko Viktoriia V. , Melnyk Nataliia H.
Published: August 2021

The aim: To study the association between the effectiveness of treatment with pioglitazone non-alcoholic fatty liver disease (NAFLD) in patients with obesity and PPARG rs1801282 (Pro12Ala)-polymorphism in Ukrainians.
Materials and methods: 123 patients with NAFLD in combination with obesity 1, 2, 3 classes were included in comprehensive weight loss program (5 visits, 12-weeks). The case group was treated with pioglitazone 15 mg / day, while the control group received only program. Ultrasound (US) steatometry and genetic testing rs1801282 polymorphism in PPARG gene were performed.
Results: Pioglitazone, PPARG rs1801282 genotype, CAP before treatment, previous weight loss attempts, and duration of obesity were associated with the change in controlled attenuation parameter (CAP) during treatment. There was a significant association between the target CAP reduction achievement and pioglitazone treatment (adjusted odds ratio 0.23, 95% CI 0.07–0.73; p = 0.01) with the CC genotype of PPARG gene (adjusted odds ratio 92.9, 95% CI 7.4–1159; p < 0.001) compared to patients with the CG genotype.
Conclusions: Pioglitazone and PPARG rs1801282 polymorphism could influence on dynamics of CAP reduction during treatment.
TRAINING OF SOCIAL WORK BACHELORS TO APPLY TECHNOLOGIES OF MEDICAL SOCIAL WORK
Authors: Bartosh Olena P. , Danko Dana V. , Kozubovska Iryna V. , Povidaichyk Oksana S.
Published: August 2021

The aim: To develop, substantiate and experimentally test the model of social workers’ training to apply medical social work technologies in the professional activities.
Materials and methods: Mixed methods design was applied. The experimental work was conducted in stages: 1) pilot study of social work curriculum of Ukrainian universities directed on the readiness formation to apply technologies of medical social work; 2) model developing with targeted, content, functional-procedural, analytical-resultative components; 3) pedagogical experiment on the learning procedure provision to students. At various stages, the study involved 48 teachers from 7 Ukrainian universities, 229 social work bachelors, 43 practical social workers.
Results: indicated that the implemented training positively leveled up in the experimental group the students’ readiness formed to apply technologies of medical social work. The number of students with high level − increased by 28.9%; with sufficient level − increased by 33.4%; with average level − increased by 8.9%; with low level − decreased by 71.1%.
Conclusions: The obtained results confirmed the efficacy of the modified program on social workers’ training to apply medical social work technologies in the professional activities.
FUNCTIONAL DISORDERSOF THE SALIVARY GLANDS IN PATIENTS WITH COMPRESSION AND DISLOCATION DYSFUNCTION OF THE TEMPOROMANDIBULAR JOINT AND THEIR CORRECTION
Authors: Rybalov Oleg V. , Yatsenko Pavel I. , Andriyanova Olga Yu. , Ivanytska Elena S. , Korostashova Maria A.
Published: August 2021

The aim: Is to assess the functional state of parotid glands and general secretion in patients with compression, dislocation dysfunction of TMJ, to correct the revealed disorders.
Materials and methods: We examined 46 patients with dysfunction of TMJ. Examination included TMJ zonography and salivary glands sonography. We studied the general and parotid secretion, transparency, viscosity, pH of the oral fluid and the secretions of the parotid glands before and after treatment. The treatment of dysfunction and hyposialosis included the repositioning of the articular heads of the lower jaw in the correct anatomical position, the use of a repositioning plate on the posterior teeth at the compression side of the articular head, bougienage of the duct of the parotid gland, administration of 10% magnesium-mineral solution of bischofite into the gland.
Results: In patients with TMJ dysfunction, a significant decrease in the oral fluid content was noted before treatment. The saliva transparency was reduced, the viscosity was increased, the pH was slightly acidic. A study, which was carried out a month after completion of the course of treatment showed that all the studied parameters corresponded to those in healthy individuals.
Conclusions: The study confirmed that in compression and dislocation dysfunction of TMJ, there are disorders of the functional state of the salivary glands.
PREDICTORS OF BRONCHOPULMONARY DYSPLASIA DEVELOPMENT AND COMORBIDITIES OF PREMATURITY ASSOCIATED WITH RESPIRATORY SUPPORT TECHNIQUES IN PREMATURE NEONATES
Authors: Sorokina Olena Yu. , Bolonska Anna V.
Published: August 2021

The aim of the study was to analyze and identify risk factors for the development of moderate and severe bronchopulmonary dysplasia, retinopathy of prematurity, necrotizing enterocolitis in preterm neonates in intensive care unit and during any kind of respiratory support.
Materials and methods: A simple retrospective-prospective blind controlled non-randomised study included 28-32 weeks of gestational age 122 newborns with respiratory distress syndrom, who were treated in the neonatal intensive care units of two medical institutions of Dnipro from 2016 to 2020. Among 122 children neonates were divided into two groups according to particularities of respiratory support, prior type of noinvasive ventilation and infusion volume per day. The uni-variate Cox regressions using clinical variables identified specific clinical variables associated with development of moderate and severe BPD, retinopathy of prematurity, necrotizing enterocolitis, mortality rate (based on odds ratio and 95% confidence interval (95% CI). Then, significant clinical variables were used to build a multivariate Cox regression models. by backwards elimination of non-significant clinical variables. To estimate discriminative ability of comorbidities predictors we conducted ROC-analysis.
Results: The patients with moderate and severe BPD significantly longer were mechanically ventilated and received О2 more than 30% in inhaled gas mixture, therefore every day of MV and/or additional oxygen >30% led to increase in probability of BPD development by 15% (p=0,01), АUC=0,78 (95% CI 0,66-0,89). Significant predictors of moderate and severe retinopathy of prematurity were body weight (AUC 0,64 (95% CI 0,51-0,77) (p=0.03), duration of non-invasive ventilation by NIV PC (AUC 0,68 (95% CI 0,54-0,83) (p <0.01), CPAP (AUC 0.63) (95% CI 0.49-0.76) (p = 0,04) and caffeine administration (AUC 0,68 (95% CI 0,59-0,77) (p=0.01). Patients who developed NEC had a statistically significantly lower daily infusion volume AUC 0,68 (0,59-0,77) p <0.01, later onset of enteral nutrition AUC 0,68 (95% CI 0,59-0,77) p <0.01, lower hemoglobin levels on the first, third and seventh days of life AUC 0,67 (95% CI 0,57-0,77) p <0.01, as well as the level of leukocytes AUC 0,65 (95% CI 0,56-0,75) p = 0,01 and platelet count AUC 0,67 (0,58-0,77) (p <0.01) during the first 7 days of life.
Conclusions: The results of the study revealed risk factors for intensive care in general and respiratory support in particular, which significantly increase the risk of developing comorbidities of prematurity. Among them are relatively controlled, it is the duration of mechanical ventilation and NIV, which increase the risk of BPD and retinopathy of prematurity. Other risk factors which we can manage include nutrition state, anemia and supplemental oxygen.
CLINICAL AND IMMUNOLOGICAL ASPECTS OF VERIFICATION OF LATENT AUTOIMMUNE DIABETES IN ADULTS AT EARLY STAGES OF DISEASE MANIFESTATION
Authors: Tykhonova Tetiana М. , Belozоrov Igor V. , Barabash Nadiya Ye. , Martymianova Larysa O.
Published: August 2021

The aim: To establish diagnostic markers of LADA at the stage of manifestation based on the analysis of clinical and anamnestic data, the results of immunological examination of patients with different types of DM.
Materials and methods: Study included 121 patients with LADA (1st (main) group), 60 patients with type 1 DM (2nd group), 81 patients with type 2 DM (3d group). The examination included analysis of complaints, medical history, determination of anthropometric data, studies of the level of antibodies to glutamic acid decarboxylase (GAD ab), cytoplasmic antigen (ICA ab), tyrosine phosphatase (IA-2 ab).
Results: Criteria of LADA diagnosis included slow nature of DM course, the average age of the disease onset (45,02±9,96) years, combination of diabetic complaints with gradual weight loss, frequent detection of DM (64,46%) on request, fairly high level of glycemia at diagnosis ((14,12±4,57) mmol/l)), the possibility of ketonuria episodes in a certain amount (23,14%) of cases in the absence of acute ketoacidotic states. The presence of excess body weight and even obesity is not a criterion for excluding LADA.
Conclusions: To verify the diagnosis of LADA it is necessary to study of at least two types of antibodies. The most conclusive is the determination of GAD ab and IA-2 ab.
COMPERATIVE STRUCTURE OF MUCOSA COAT OF THE PIG`S AND THE HUMAN`S RECTUM
Authors: Plakhotnyi Roman О. , Кerechanyn Іryna V. , Fedoniuk Larysa Ya. , Kovalchuk Nataliia V. , Dehtiariova Oksana V. , Singh Gagandeep
Published: August 2021

The aim: To determine whether the pig could be used as biomodel for study and reconstruction of rectal pathology for development the new approaches for prevention and treatment of rectal diseases.
Materials and methods: For the research the rectum of 8 vietnamese pot-bellied pigs were used. Via macro- and microscopy the structure of mucosa coat of the pig`s and human`s rectum was compared.
Results: Mucosa coat`s peculiarities of pig`s and human`s rectum in comparative aspect are described in this article. With the help of traditional methods, known as macroscopy the structure of the pig`s rectal mucosa was study and compared wih macrostructure of human`s rectum. The microstucture of pig`s rectal mucosa was study due to histological method too. The macro- and microscopy demonstrated that structure of pig`s and human`s rectal mucosa are similar and includes same structural components.
Conclusions: Thus, the research proved that pigs can be used as biomodels in biomedical research for creating various new methods and applications in approaching the prevention and treatment of rectal pathology in humans.
EFFECTIVENESS OF COMPOSED HERBAL EXTRACT IN THE TREATMENT OF GINGIVITIS AND ORAL AND PHARYNGEAL MUCOSA – REVIEW OF STUDIES
Authors: Schönknecht Karina , Surdacka Anna , Rudenko Lesia
Published: August 2021

Intensive studies on properties of synthetic compounds are simultaneously conducted with studies on the effectiveness and safety of drugs derived from natural compounds. These drugs have been effectively used for years in dentistry, in treatment of inflammatory conditions of the oral cavity and in laryngology, in treatment of pharyngeal inflammatory conditions. The subject of this article is a compilation of studies conducted on medicinal products containing composed ethanolic extract as an active substance, and obtained from: chamomile capitulum (Matricaria recutita L.), oak bark (Quercus spp.), sage leaf (Salvia officinalis L.), arnica herb (Arnica spp.), calamus rhizome (Acorus calamus L.), peppermint herb (Mentha piperita L.), thyme herb (Thymus spp.) Preclinical studies confirmed that a particular tested plant extract exhibits antimicrobial (antibacterial, antifungal and antiprotozoal) as well as anti-inflammatory, immunomodulatory and astringent properties. Under clinical conditions, it was confirmed that drugs containing the analysed extract used in periodontology, in prevention and complex treatment of gingivitis, periodontitis as well as diseases of oral mucosa (but also the throat) of viral, bacterial, fungal and protozoal aetiology significantly improved the effectiveness of therapy, shortened the treatment and improved the patients’ quality of life. The above preparations used in dental surgery contributed to faster tissue regeneration, more quickly relieved pain and swelling after a surgery or difficult dentition. Furthermore, drugs containing the above-mentioned extract can also be successfully used for oral cavity decontamination in the case of various diseases of teeth or the oral and pharyngeal mucosa. The tested composed herbal extract (CHE), applied in the form of a mouthwash and in the form for topical application with benzocaine content (CHEB), is a component of drugs which are great alternatives to widely used synthetic drugs. They are characterised with high effectiveness, comparable to that of synthetic agents, and a higher safety profile. Results of pharmacological and clinical studies justify their use in both prevention and treatment of inflammatory diseases of the gums, periodontium, oral cavity and pharynx.
The Experience of Disconnecting from Information and Communication Technology (ict) While Traveling in Late Modernity
Authors: Lachance Jocelyn
Published: August 2021

Various authors have shown how information and communication technologies (ICTs) are transforming the travel experience to the point of undermining the original traveler objectives. Largely based on the traveler and technology relationship, most previous analyses have assumed that the
changing travel experience is attributable to ICTs. From a survey based on 53 semistructured interviews, this article shows the inadequacy of seeking to understood traveler attempts to disconnect from ICTs as symptomatic of the relationship between travelers and technologies. The authors contend
that it is equally important to understand travelers' use of ICTs within the wider context of late modernity, which has induced particular relationships among relatives and the deployment of ICTs. The article highlights limitations of previous ethnographic approaches in ICT studies using the
example of their role in the travel experience.
The eﬀectiveness of psychological support with the use of hepato-immunoprotectors as predictors in drug therapy of tuberculosis
Authors: Kolomiets V. M. , Alymenko M. A. , Kovalenko A. L. , Pavlenko E. P. , Talikova E. V.
Published: August 2021

The aim of the study was to evaluate the effectiveness of psychological (adherence to treatment) and accompanying drug therapy depending on the form of pulmonary tuberculosis. The results of complex therapy of 326 patients with various forms of pulmonary tuberculosis are considered. All patients received etiotropic treatment, taking into account the sensitivity of the pathogen to anti-tuberculosis drugs, as well as support therapy, including psychological support and, if indicated, hepatoprotective therapy with Remaxol. When analyzing the dependence of the psychoemotional state of patients on the form of the tuberculous process in the lungs, it was noted that high adherence to therapy was observed in one third of patients in all groups (DTL — 26.1%, ITL — 28.6%, FCTL — 32.8% and ATL — 31.8%, respectively, P>0.05). The results obtained may be associated with a high level of resistance of mycobacterium tuberculosis excreted from pa tients: out of 232 patients with low adherence to treatment (NUP and UUP), 97 (36.2%) showed drug resistance of the pathogen to two or more etiotropic drugs, which, in turn, caused prescription of reserve drugs. Thus, the determination of the level of adherence to treatment is justified and is aimed at correcting the psychological support of patients with pulmonary tuberculosis, which makes it possible to increase the effectiveness of therapy in these patients. The appointment of the latter in a number of patients led to the development of hepatotoxic reactions, which served as the basis for the inclusion in the therapy regimens of the accompaniment of Remaxol (intravenous drip of 400 ml, course No. 5–7). Pronounced hepatoprotective (improved transaminase parameters) and insignificant immunoprotective (positive dynamics of the cytokine profile) effects were noted during treatment. The noted changes in the immunogram can be associated with the proven antioxidant and membrane stabilizing effect of succinic acid, which is part of Remaxol. These changes require further research.
Greenshipping mit Edelstahlkomponenten
Authors: Herrling-Tusch Ursula
Published: August 2021

Etwa 90 Prozent der weltweit gehandelten Güter werden heute auf dem Seeweg transportiert – mit gigantischen CO2-Emissionen. Seit Anfang des 21. Jahrhunderts sind deshalb zunehmend Frachtsegler unter dem Motto „Wind statt Schweröl“ unterwegs, um Waren und Güter CO2-neutral über den Atlantik zu befördern. Rostfreie Edelstahlkomponenten spielen bei der Schiffskonstruktion eine wichtige Rolle.
Berücksichtigung des Zähnezahleinflusses bei der Bestimmung der Bauteilfestigkeit von Zahnrädern mit experimentell ermittelten Zahnfußtragfähigkeitskennwerten/Consideration of the Influence of the Number of Teeth for the Determination of the Component Strength of Gears with Experimentally Determined Load Carrying Capacity Parameters
Authors: Leonhardt Christoph , Otto Michael , Stahl Karsten
Published: August 2021

Zahnfußtragfähigkeitskennwerte für Zahnräder werden in der Praxis üblicherweise in Pulsator- oder Laufversuchen ermittelt. In den genannten Prüfverfahren liegen, bedingt durch den Aufbau des Prüfgeräts, unterschiedliche Beanspruchungen in den zu prüfenden Zahnrädern vor. Dies kann dazu führen, dass für das selbe Bauteil je nach Prüfverfahren unterschiedliche Tragfähigkeitskennwerte ermittelt werden. Es wird ein statistisches Modell vorgestellt, das den Einfluss der Zahl der beanspruchten Zähne auf die Tragfähigkeitskennwerte eines Zahnrads berücksichtigt, um eine zuverlässige Auslegung eines Getriebesystems sicherzustellen. Basierend auf der Modifikation eines bestehenden Modells kann ein relevanter statistischer Zähnezahleinfluss im Bereich praxisrelevanter Zähnezahlen nachgewiesen werden. Für die praktische Anwendung wurden aus den Ergebnissen der Auswertung des statistischen Modells einfach anwendbare Methoden zur Umwertung von Festigkeitskennwerten im Auslegungsprozess abgeleitet. Diese ermöglichen eine zuverlässige Auslegung von Getriebesystemen, die im Kontext steigender Leistungsdichte und der Umsetzung von Leichtbaukonzepten zunehmend an Bedeutung gewinnt. Die mathematische Formulierung des Ansatzes ermöglicht die einfache Anpassung für die Auswertung anderer Schadensarten, Verteilungsformen und Versuchsstreuungen.
Host-guest interaction and properties of cucurbit[8]uril with chloramphenicol
Authors: Zhang Lin , Zheng Jun , Luo Guangyan , Li Xiaoyue , Zhang Yunqian , Tao Zhu , Zhang Qianjun
Published: August 2021

The interaction between cucurbit[8]uril (Q[8]) and chloramphenicol (CPE) was investigated using single-crystal X-ray diffraction, spectroscopy, isothermal titration calorimetry (ITC) and UV-Vis, NMR and IR spectroscopy. The effects of Q[8] on the stability, in vitro release performance and antibacterial activity of CPE were also studied. The results showed that CPE and Q[8] formed a 1:1 inclusion complex (CPE@Q[8]) with an inclusion constant of 5.4736 × 105 L/mol. The intervention of Q[8] did not affect the stability of CPE, but obviously reduced the release rate of CPE in artificial gastric and intestinal juice; Q[8] has a slow-release effect on CPE. The antibacterial results showed that the minimum inhibitory concentration (MIC) of CPE and CPE@Q[8] toward Escherichia coli (E. coli) was 1.5 × 10–3 and 1.0 × 10–3 mol/L, respectively, and toward Staphylococcus aureus (SA), the MIC was 2.0 × 10–3 mol/L for both CPE and CPE@Q[8]. Therefore, Q[8] enhanced the inhibitory activity of CPE against E. coli.
ANALISIS KONTEKS DAN WUJUD EKOLOGI DINDANG ANAK UNGGAT-UNGGAT APUNG ETNIK BANJAR KALIMANTAN SELATAN
Authors: Norvia Norvia
Published: August 2021

Dindang (nyanyian atau lagu) Unggat-Unggat Apung etnik Banjar adalah dindang yang mengiringi sebuah permainan tradisional anak-anak yang berfungsi sebagai hiburan di waktu berkumpul orang tua dengan anak-anaknya di rumah. Sastra lisan khususnya dindang anak Unggat-Unggat Apung etnik Banjar merupakan dindang yang mulai kehilangan penuturnya. Hal ini disebabkan minimnya pelestarian dindang ini dalam bentuk dokumentasi tertulis, serta sudah tidak dikenalnya dindang ini di kalangan anak-anak etnik Banjar. Dindang sebagai salah satu bagian dari representasi kehidupan manusia seringkali memuat unsur budaya dan lingkungan manusia. Adanya penuangan unsur ekologi dalam sastra lisan khususnya dindang anak Unggat-Unggat Apung etnik Banjar semakin memperkuat adanya hubungan yang erat antara etnik Banjar dengan alam. Metode deskriptif kualitatif yang digunakan dalam penelitian ini akan memberikan gambaran dalam bentuk kata-kata dan gambar yang mengacu pada tujuan penelitian. Hasil penelitian menunjukkan bahwa dari 33 larik dindang anak Unggat-Unggat Apung etnik Banjar ditemukan unsur ekologi flora 3 kata, unsur ekologi fauna 4 kata, dan unsur ekologi budaya yang tergolong peralatan dan perlengkapan hidup etnik Banjar terdiri atas 4 kata. Kajian ekologi sastra dalam penelitian ini diterapkan sebagai upaya menggali hubungan antara sastra dan ekologi etnik Banjar sebagaimana tertuang dalam dindang anak Unggat-Unggat Apung etnik Banjar.Dindang (song) Unggat-Unggat Apung of the Banjar ethnic group is a song that accompany a traditional children's game that functions as entertainment when parents gather with their children at home. Oral literature, especially the Dindang children of Banjar ethnics, Banjar ethnic is a song that has lost its speakers, this is due to the lack of preservation of this song in the form of written documentation, and this song is unknown among the Banjar ethnic children. Dindang as one part of the representation of human life often includes elements of human culture and environment. The existence of the pouring of ecological elements in oral literature, especially the existence of a close relationship between ethnic Banjar with its nature which is reflected in the song. The qualitative descriptive method used in this study will provide an overview in the form of words and images that refer to the purpose of the study. The results of the study found that from 33 lines of Dindang Unggat-Unggit Apung, found three ecological elements of flora, four ecological elements of fauna, and cultural ecological elements belonging to Banjar ethnic equipment and life equipment consisting of 4 words. The study of literary ecology in this study was applied as an effort to explore the relationship between literature and ecology of the Banjar ethnicity as set in the song of Dindang Unggat-Unggit Apung.
KEKERASAN VERBAL DALAM NASKAH DRAMA “PERANG BANJAR HAMPIR BERAKHIR” KARYA H. ADJIM ARIJADI (Verbal Violence In The Drama Text Of “Perang Banjar Hampir Berakhir” by H. Adjim Arijadi)
Authors: Ahya Annisa Nurshifariani
Published: August 2021

Penelitian ini bertujuan untuk mendeskripsikan kekerasan verbal yang terdapat pada naskah drama. Kekerasan verbal adalah bentuk kekerasan menggunakan kata-kata yang bisa menyakiti hati seseorang. Penelitian ini berjenis penelitian kualitatif dengan metode deskriptif. Sumber data berupa naskah drama “Perang Banjar Hampir Berakhir” Karya H. Adjim Arijadi dan data berupa kutipan kata dan kalimat dialog dalam naskah drama yang mengandung unsur kekerasan verbal. Teori yang digunakan adalah teori pragmatik tindak tutur direktif dan ekspresif. Teknik pengumpulan data dengan teknik catat, yaitu mencatat hasil temuan kekerasan verbal dalam naskah drama kemudian tahap pengolahan data dilakukan dengan aktivitas reduksi data, penyajian data, dan penarikan kesimpulan. Berdasarkan hasil analisis, menunjukkan bahwa tuturan yang paling banyak ditemukan yaitu pada tuturan yang mengandung kekerasan verbal bentuk mencela sebanyak 9 tuturan, sedangkan fungsi menolak yang paling banyak ditemukan pada tindak tutur direktif sebanyak 9 tuturan, dan fungsi rasa tidak senang yang paling banyak ditemukan pada tindak tutur ekspresif sebanyak 8 tuturan. This study aims to describe the verbal violence contained in drama scripts. Verbal abuse is a form of violence using words that can hurt someone. This research is a qualitative research with descriptive methods. The data sources are in the form of a drama script “The Banjar War Almost Ending” by H. Adjim Arijadi and the data are quotations of words and dialogue sentences in the drama script that contain elements of verbal violence. The theory used is the pragmatic theory of directive and expressive speech acts. The data collection technique uses note-taking techniques, namely recording the findings of verbal violence in a drama script and then the data processing stage is carried out by data reduction, data presentation, and conclusion drawing. Based on the results of the analysis, it shows that 9 utterances that contain verbal violence in the form of censure are mostly found, while the function of rejecting is mostly found in directive speech acts as many as 9 utterances, and the function of displeasure is mostly found in actions expressive speech in 8 speeches.
NILAI PROFETIK DALAM NOVEL MUHAMMAD: LELAKI PENGGENGGAM HUJAN KARYA TASARO GK (STRUKTURAL SEMIOTIK) (The Prophetic Value in the Novel Muhammad: Lelaki Penggenggam Hujan by Tasaro G.K. [Structural Semiotic])
Authors: Jalalludin Muhammad , Zuriyati Zuriyati , Lustyantie Ninuk
Published: August 2021

Novel Muhammad: Lelaki Penggenggam Hujan karya Tasaro G.K. menceritakan dua kisah, yakni kisah Nabi Muhammad saw. dan kisah seorang lelaki Persia bernama Kashva. Dikisahkah bahwa Kashva pergi mencari lelaki yang kelahirannya telah dijanjikan oleh banyak kitab suci sebagai nabi baru yang akan membawa rahmat manusia dan semesta alam. Di tengah-tengah kisah pencarian itulah terselip kisah Nabi Muhammad Saw. Dari kisah-kisah tersebutlah tersimpan pesan profetik berupa nilai humanisasi (amar ma’ruf), nilai liberasi (nahi munkar), dan transendensi (tu’minu billah). Penelitian ini membahas ketiga nilai profetik tersebut dengan tinjauan struktural semiotik. Penelitian ini bertujuan untuk mengetahui nilai profetik dalam novel Muhammad: Lelaki Penggenggam Hujan karya Tasaro G.K. ditinjau dari struktur novel dan semiotik. Penelitian ini menggunakan pendekatan kualitatif dengan metode analisis isi model Philipp Mayring kategori deduktif. Hasil penelitian ini menunjukkan adanya nilai profetik yakni nilai humanisasi, nilai liberasi, dan nilai transendensi yang begitu melekat sesuai dengan realitas Al Quran sebagai sumber utama ilmu pengetahuan. Selain itu, banyak sekali pengetahuan adab dan karakter yang tercermin dari ketiga nilai profetik yang baik diterapkan di sekolah sebagai suatu bentuk ekspresi dari upaya penanaman karakter pada siswa. The novel of Muhammad: Lelaki Penggenggam Hujan by Tasaro G.K. tells two stories, the story of the Prophet Muhammad and the story of a Persian man named Kashva. It is said that Kashva went to find a man whose birth was promised by many scriptures as a new prophet who would bring grace to mankind and all the universe. In the middle of the search story, the story of the Prophet Muhammad was tucked. From these stories, prophetic messages are stored in the form of the value of humanization (amar ma'ruf), the value of liberation (nahi munkar), and transcendence (tu'minu billah). This study discusses the three prophetic values with a semiotic structural review. This study aims to determine the prophetic value in the novel Muhammad: Lelaki Penggenggam Hujan by Tasaro G.K. in terms of the novel and semiotic structure. This study used a qualitative approach with the content analysis method of the deductive Philipp Mayring model. The results of this study indicate that there are three prophetic values namely, the value of humanization, the value of liberation, and the value of transcendence which is so inherent in accordance with the reality of the Al-Quran as the main source of knowledge. In addition, there is a lot of knowledge of manners and character which is reflected in the three good prophetic values applied in schools as a form of expression of efforts to cultivate character in students.
PEMODELAN UML UNTUK SISTEM INFORMASI PERSEWAAN ALAT PESTA
Authors: Abdillah Rahman
Published: August 2021

Perancangan perangkat lunak menggunakan pemodelan UML telah banyak digunakan dikalangan praktisi dan akademisi. Salah satu kelebihan dari penggunaan diagram UML adalah fleksibilitas dan dapat menggambarkan sistem perangkat lunak lebih rinci dan detail. Dalam artikel ini, penulis menggunakan metode SDLC yang dikenal sebagai tahapan proses pengembangan perangkat lunak . Adapun penulisan artikel ini bertujuan untuk memberikan kontribusi keilmuan yang berupa rekomendasi dalam hal perancangan sistem informasi alat pesta. Adapun metode penelitian yang digunakan dalam penelitian ini adalah studi lapangan, studi pustaka dan implementasi. Dalam kaitanya dengan implementasi, penulis menggunakan bahasa pemrograman Java dan menggunakan MySQL sebagai basis data. Adapun hasil yang didapat dari penulisan artikel ini adalah berupa pengembangan kualitas perangkat lunak, serta berupa rekomendasi diagram-diagram UML yang dapat digunakan oleh pihak-pihak pengembang perangkat lunak terkait usaha jasa persewaan.
Sistem Monitoring Kualitas Kekeruhan Air Berbasis Internet Of Thing
Authors: Rikanto Tito
Published: August 2021

Penggunaan air dimasa kini sangatlah besar, banyak industri yang mencemari daerah mata air dan penebangan hutan secara liar juga merupakan penyebab menurunnya kualitas air. Kondisi air pada bak tampung dapat berubah-ubah dan pemantauan masih secara manual untuk memastikan kualitas air baik untuk digunakan, maka diperlukan alat otomatis untuk mengontrol kualitas air. Studi ini berbasis Internet of Things menggunakan Arduino UNO,ESP8266 dan LDR sebagai sensornya. Pengujian modul menggunakan 30 sampel air berbeda kondisi dengan total uji sampel sebanyak 90 kali dan pengujian dengan konsep waterflow.Hasil penelitian berupa perangkat modul yang dapat memantau dan mengkontrol kualitas kekeruhan air diharapkan mampu memberikan hasil akurat dalam memonitoring kualitas air pada bak tampung serta dapat mempermudah dan membantu manusia untuk terhindar dari penyakit akibat kualitas air yang tidak baikBerdasarkan hasil perhitungan uji sampel, penerapan mikrokontroler berbasiskan Internet of Things dalam memonitoring kualitas kekeruhan air didapat tingkat keakurasian modul dalam mendeteksi kualitas air sebesar 96,67%.Kata kunci: internet of things, miikrokontroler, monitoring kualitas air, waterflow.
Sistem Penunjang Keputusan Penentuan Reward Bagi Mitra Terbaik Menggunakan Metode Simple Additive Weighting (SAW) (Studi Kasus : PT. Telkom Akses)
Authors: FANDI AZIZ
Published: August 2021

In the development of the world of work, a reward is an important factor to improve the quality of human resources as well as an appreciation for those with enhancement. Therefore, a company should be careful in performing its assessment. Thus, a decision support system application is required to assist a company in performing the assessment process. Accordingly, the decision-making process uses the Simple Additive Weighting (SAW) method. Results of the system functionality can run 100% well and as needed, and the result of the system accuracy test are 100%. This indicates that a decision support system can function properly with the Simple Additive Weighting (SAW) method.

Keywords: Reward, Simple Additive Weighting (SAW), Decision Support System
Analisis Sentimen Masyarakat Pada Twiter Terhadap Isu Covid-19 Menggunakan Metode Lexicon Based
Authors: Winarso Doni , Yanda Noor Yudha  , Syahril
Published: August 2021

Twitter merupakan salah satu media sosial yang memungkinkan penggunanya untuk menulis tentang berbagai topik dan membahas isu-isu yang sedang terjadi. Salah satu isu yang sedang menjadi trending topic saat ini adalah Covid-19. Banyak kalangan di masyarakat tersebar isu bahwa Covid-19 ini merupakan konspirasi dan tidak sedikit juga yang mempercayai bahwa Covid-19 ini nyata. Oleh karena itu perlu suatu analisis sentimen untuk mengetahui apakah Covid-19 ini nyata atau konspirasi berdasarkan opini masyarakat di Twitter, metode yang digunakan adalah Lexicon Based untuk mengelompokkan opini masyarakat ke dalam kategori sentimen positif, negatif atau netral. Hasil dari penelitian ini menunjukkan bahwa masyarakat pada twitter yang percaya bahwa Covid-19 adalah nyata masih cukup tinggi dibandingkan dengan masyarakat yang mempercayai isu konspirasi Covid-19. Hal tersebut dapat dilihat dari persentase sentimen kategori positif sebesar 58.08%, opini sentimen kategori negatif sebesar 37.61%, dan opini sentimen kategori netral sebesar 4.31%.
Oral leukoplasia
Authors: Ciubuca Liviu
Published: August 2021

Considerată o leziune cu potenţial de malignizare, leucoplazia orală a fost definită de către Organizaţia Mondială a Sănătăţii, în 1978, drept „o pată sau placă albă, nu mai mică de 5 mm diametru, care nu poate fi înlăturată prin ştergere şi care nu poate fi clasificată în nici o altă boală diagnosticabilă“. Ulterior, în 1995, OMS a revenit asupra definiţiei: „Leucoplazia orală este o leziune predominant albă a mucoasei, care nu poate fi încadrată în nici un alt tip bine definit de leziuni; unele leziuni se vor maligniza“.
Factors Affecting the Utilization of Medical Check Up at the Putri Hijau Level II Hospital
Authors: Sembiring Putri Junita , Simanjorang Aisyah , Aini Nur
Published: August 2021

The purpose of this research is to investigate the variables that affect the use of medical services. At the Putri Hijau Level II Hospital, you may get checked out. It was decided to employ a kuantitatif research design with a cross sectional design for this particular investigation. Patients who came in for a medical check-up at the Putri Hijau Level II Hospital were included in the research study. According to the results of the first survey, the total number of patients who had medical examinations in 2019 was 2135 individuals. We needed to look at 100 different individuals for our experiment. The chi square test and multiple linear regression were the statistical tests that were used. The results of the chi square test study revealed that the variable service quality (reliability p-value = 0,000, responsiveness p-value = 0,000, assurance p-value = 0,036, empathy p-value = 0,003, physical evidence p-value = 0,026) obtained a p-value less than 0.05, the variable facility p-value = 0.000, the variable rate / price p-value = 0.000, and the variable patient perception obtained a p-value Patient views of the use of Medical Check Up services are associated with service quality (reliability, responsiveness, assurance, empathy, physical evidence) as well as medical facilities, rates / pricing and patient perceptions of the usage of Medical Check Up services (p-value = 0.039 0.05). Using multivariate analysis, it was discovered that one of the variables in this research, the Facility variable, had the most influence on the outcome.
Analysis of the Implementation of Patient Safety Culture with the AHRQ Model at Mitra Medika Hospital Tanjung Mulia Medan
Authors: Juliani Naeni , Fitriani Arifah Devi , Theo Deli
Published: August 2021

Safety Culture is a collaborative environment where clinical staff treat one another with respect by involving or empowering patients and families so that each Professional provides patient-focused care. The purpose of this study was to determine the implementation of a patient safety culture with the AHRQ model in Mitra Medika Tanjung Mulia General Hospital Medan. This research uses a mix of methods, namely qualitative and quantitative. The population of this study were all staff on duty in each hospital unit associated with 450 patients at MItra Medika Hospital, so the sample was 75 people using simple random sampling technique. The main research informants were one officer each in each installation.Unit Mitra Medika Tanjung Mulia General Hospital Medan, namely 10 people, one key informant, and one triangulation informant.The results of the study show that the description of expectations and managerial actions of patient safety is 68%, organizational learning is 100%, cooperation in units is 76%, communication open by 80%, feedback about the error of 75%, the dimension of non-punitive response to errors is 55%,Staffing 51%, management support for patient safety efforts by 77%, cooperation between units of 61%, handsoff work and changing patients was 71%,the overall perception of hospital staff about patient safety was 63%, reporting frequency was 63%. With the research results, it is expected that Mitra Media Tanjung Mulia General Hospital Medan is expected to be able to initiate, maintain, and develop an ongoing patient safety program and implement the existing safety culture.
On the landscape of youth participation in science policy
Authors: Agarwal Shashank
Published: August 2021

Despite being important policy stakeholders, the youth remain largely absent from policy building and implementation. However, the growing literature has vividly illustrated the capacity of the youth from diverse age groups to make meaningful contributions to policy. In particular, university students are emerging as significant actors in science policy owing to their unique perspectives and knowledge. By drawing from the literature, we emphasize that the youth are capable of directly contributing to diverse policy matters while also indirectly benefiting from their participation. Consequently, there is a crucial need for initiating programs for promoting youth participation. Furthermore, to ensure the fruitfulness of such programs, more systematic research ought to be done with regard to the accomplishments and challenges of youth participation.
The path to herd immunity: is mandatory vaccination the answer?
Authors: Cheng Steven S. , Lepe Biana A.
Published: August 2021

Vaccination is a public health measure that is routinely performed to reduce the risk of contracting a particular infectious disease. Taking advantage of the body’s immune system, vaccination can confer immunity against disease-causing pathogens. Though vaccination generally is not able to yield absolute immunity, the procedure has nonetheless improved public health and reduced infectious disease mortality globally, saving millions of lives each year [1]. If a high enough proportion of a population obtains immunity to a particular pathogen such that the spread of the associated disease has slowed and members of the population without immunity are also protected, then herd immunity has been achieved. Consequently, there have been a number of debates about using policymaking tools to achieve this high population vaccination rate, including policies of mandatory vaccination. Here, we discuss the scientific background of vaccination, present frameworks for understanding the arguments for and against mandatory vaccination policies, and highlight data and a case study in support of these arguments within the context of the United States. We hope to better inform the policymaking community of the factors that must be weighed when considering a mandatory vaccination policy.
Unifying global pandemic preparedness efforts
Authors: Siller-Farfán Jesús A. , Gaglione Stephanie
Published: August 2021

The COVID-19 pandemic illustrates the need for pandemic preparedness to be considered a global rather than a national metric. The 2005 International Health Regulations and supporting policy provide a foundation for building pandemic preparedness and health security in all countries. Examining the engagement of high-income, middle-income, and low-income countries in existing policies and programs, each income group can redress different challenges. With improved engagement in international regulations, targeted donor programs by high-income countries, and strengthened core health capacities in middle- and low-income countries, global pandemic preparedness is possible within the existing policy landscape.
A perspective on equity in the transition to electric vehicles
Authors: Hardman Scott , Fleming Kelly L. , Khare Eesha , Ramadan Mahmoud M.
Published: August 2021

Since the recent introduction of electric vehicles began in 2008-2010, 80 different electric vehicle models and close to 2 million electric vehicles have been sold in the US. The need to commercialize electric vehicles meant research and policy has so far focused on how to establish the early electric vehicle market. The newness of electric vehicles, their high upfront cost, the need for charging access, and other issues meant equity has been overlooked. As regions progress toward goals of 100% electric vehicle sales, research and policy should consider how to establish a more equitable electric vehicle market so that the benefits of electrification are experienced by all and so that low-income households are not imposed with higher transportation costs.
An interview with Professor Sheila Jasanoff: On lessons from science, technology, and society
Authors: Chang Joan , Sharma Maanas , Seetharam Kushal
Published: August 2021

MIT Science Policy Review spoke with Professor Sheila Jasanoff about her pioneering work in Science and Technology Studies (STS), the role of the public in policymaking, and some of the important lessons and recommendations drawn from her work in STS. She is the Pforzheimer Professor of Science and Technology Studies at the Harvard Kennedy School, where she founded and directs the STS Program. Her work exploring the role of science and technology in law and public policy has been internationally recognized and the insights she shared are sure to benefit scientists interested in entering the policy field. This interview was edited for clarity.
An Interview with Professor Jonathan King. Part II: On the influence of private funding on public policy
Authors: Gill Manraj S. , Cascino Jennifer A. , McCormick Dylan M.
Published: August 2021

In his many years of advocacy efforts from within academia, Professor King has centered the issue of nuclear weapons disarmament. His numerous initiatives within this realm emphasize that disarmament is fundamentally a question of funding, making clear that a society that prioritizes the funding of warfare does so at the cost of failing to fortify public health and healthcare. Dr. King currently chairs the Nuclear Disarmament Working Group of Mass Peace Action (MPA), a nonprofit that works to generate political momentum toward “a more just and peaceful U.S. foreign policy” [1]. At MPA, he has also helped to organize the Healthcare not Warfare campaign, which calls for the prioritization of tax dollars toward healthcare, housing, public transport, food security, and education through major cuts to the annual federal military budget.

His career-long critique of the military-industrial complex stems from his days participating in Science for the People, an organization that emerged from the antiwar culture of the late 1960s to push the scientific establishment to approach science as a social endeavor by using scientific discoveries for the advancement of social causes rather than profit-making and warfare. His advocacy work critically examines the links between funding, public policy, and the types of societies that we build.

In part II, we explore these issues with Professor King to gain his perspective on the relationship that funding (of higher education, lobbying, research) has with the social and scientific institutions that we configure.
An interview with the Hon. Chris Fall: On fostering innovation in federal research & development
Authors: Klein Ethan A. , Clingman Brooks
Published: August 2021

The MIT Science Policy Review spoke with the Hon. Chris Fall, who previously served as the Senate-confirmed Director of the United States Department of Energy’s (DOE) Office of Science and the Acting Director of DOE’s Advanced Research Projects Agency-Energy (ARPA-E). Dr. Fall’s career has included time as a university professor, chief scientist of a government agency, and White House policy advisor and spanned topics ranging from neuroscience to clean energy to high-performance computing. In this interview, we discuss government models for funding and performing high-risk, high-reward research, emerging technologies with the potential to change the scientific landscape, and a vision for the future of national laboratories.
The impact of international scientists, engineers, and students on U.S. research outputs and global competitiveness
Authors: Rovito Sarah M. , Kaushik Divyansh , Aggarwal Surya D.
Published: August 2021

International scientists, engineers, and students have made and continue to make significant contributions to the U.S.’s science and engineering research enterprise. This source of talent is a comparative advantage for the U.S. and is critical for keeping the nation at the leading edge of discovery and knowledge. This paper quantifies and reaffirms the impact of international scientists and scholars, who serve as a vital source of talent fueling American ingenuity, innovation, and leadership. Bolstering measures to attract and retain top students from across the globe and fostering a culture where immigrants are welcome and can thrive is imperative for the continued success of the U.S.’s society and economy.
An interview with Professor Florence Bourgeois: On policy and regulation of clinical trials
Authors: Pollozi Shejla , Xie Cindy , Sachar Sumedha
Published: August 2021

For more than 20 years, Dr. Florence Bourgeois, MD, MPH has held multiple positions at the intersection of pediatrics, therapeutics, regulatory science, health informatics and research integrity. A graduate of Yale University, Harvard School of Public Health and Washington University School of Medicine in St. Louis, Dr. Bourgeois’ record transcends academia and medicine. In addition to being a faculty member at Harvard Medical School and the Division of Emergency Medicine and the Computational Health Informatics Program (CHIP) at Boston Children’s Hospital, she is the Director of PedRx, which aims to advance the development and evidence-based use of novel therapeutics for children globally. As the Scientific Director of the Boston Children’s Hospital Biobank, Dr. Bourgeois’ efforts focus on expanding physicians’ capacity to conduct research in pediatric populations. As the Co-Director of the Harvard-MIT Center for Regulatory Science, Dr. Bourgeois also spearheads cross-disciplinary collaborations between academia, biotechnology and pharmaceutical companies, and regulatory agencies. She is the recipient of an Innovation in Regulatory Science Award from the Burroughs Wellcome Fund and has served as an Expert Visitor to the European Medicines Agency to analyze the EU’s pediatric drug legislation. As part of this interview, we examine the relationship between clinical trials and drug development in pediatrics as well as their ethical and social impacts.
A COVID-19 járvány hatásai a nőkre, a rendőrség női munkatársaira
Authors: Torma Albert
Published: August 2021

The COVID-19 pandemic has shocked the entire world, placing an additional burden on all people, regardless of gender, age, health condition, or social status. The pandemic also affects women’s decision to have children, pregnancy, childbirth circumstances, parental involvement, health status, and partnerships. The study addresses the challenges for women, in particular the situation of the female staff serving in the police force, who also have to cope with the increased workload resulting from the epidemic.