bluuebunny/crossref_metadata_2025 huggingface dataset:
Funerary heritage tourism: definitions and principles
Authors: Rugg Julie
Published: December 2021

En muchas grandes ciudades, el ‘primer’ cementerio decimonónico es cada vez más el núcleo del turismo de cementerios. El texto considera el ‘patrimonio funerario’ como un desarrollo relacionado pero diferente. Señala la posible relación incómoda entre el turismo de cemen- terios y patrimonio funerario, en parte debido a la falta de voluntad de asociar directamente las visitas a los cementerios con la muerte. Un turismo de cementerios mal planteado puede socavar el patrimonio tangible e intangible de los cementerios. Muchos cementerios siguen en uso y, por lo tanto, deben considerase como ‘patrimonio vivo’. En estas circunstancias, la interpretación debe reconocer a los afectados como partes interesadas relevantes, mientras que los sistemas de interpretación deben comunicar con más firmeza los diversos aspectos de la mortalidad. Poner de relieve las dinámicas de ‘funcionamiento’ del cementerio es un marco narrativo poco explorado y es necesario ser consciente de que las formas de interpre- tación pueden sesgar el esfuerzo de conservación. Asimismo, se pueden plantear cuestiones éticas. En el texto sugerimos que, como mínimo, esa interpretación debería demostrar cómo la humanidad, en todas las épocas y culturas, se ha esforzado por aceptar la muerte.

In many major cities, the ‘first’ nineteenth-century cemetery is increasingly the focus of cemetery tourism. This paper recognises ‘funerary heritage’ as an associated but separate development. It indicates that there can be an uneasy relationship between cemetery tourism and funerary heritage, in part resting on unwillingness directly to associate cemetery visits with death. Poorly framed cemetery tourism can actively undermine both the tangible and intangible heritage of cemeteries. Many cemeteries are still in use, and this paper regards these sites as ‘living heritage’. In these circumstances, interpretation should acknowledge the bereaved as relevant stakeholders; interpretation needs to be more confident in the ways in which it talks about the various aspects of mortality; foregrounding how the cemetery ‘works’ presents an under-explored narrative frame; and there is a need to be aware of the ways that interpretation can skew conservation effort. Ethical issues also pertain. Here it is suggested that, at the very least, that interpretation should demonstrate how –across all times and cultures– humanity has striven to come to terms with mortality.
Demonic Temporality in Marlowe’s Doctor Faustus
Authors: Walker Katherine
Published: December 2021

“Demonic Temporality in Marlowe’s Doctor Faustus” argues that demonic beings and their temporal experiences serve as useful ways to conceptualize human beings existing in multiple timelines in Marlowe’s play. Plotting Satan’s histories in the Bible, demonology, and the ars moriendi tradition, the essay trace how early modern authors attempted to outline precisely how demonic temporality differed from humanity’s own constricted timescapes. Marlowe’s play, however, undercuts any confidence that early modern readers might have gained from these traditions, and I show how Mephistopheles furthers Faustus’s flawed conception of time as strictly earthly. Mephistopheles, too, is bound by certain temporal demands, particularly when he is forced to arrive upon the clowns Robin and Rafe’s ludic conjurations. Ultimately, Mephistopheles manipulates Faustus’s sense of temporality altogether, and the magus only learns at the very end of the play the true import of “everlasting” and Mephistopheles’s role, his experiences, within that sense of infinitude. In staging an aborted death scene that echoes the first half of ars moriendi texts, Marlowe’s disengagement from the genre rests on differences in understanding demonic temporality.
The economic feasibility of Gerga's orange (Citrus sp.) agribusiness as a new source of economic growth in Bengkulu, Indonesia
Authors: Irawan Andi , Yuristia Rahmi
Published: December 2021

This research gave the empirical verification that orange’s agribusiness can be a source of new growth for its center production region, as in case the Gerga’s orange agribusiness for Bengkulu province in Indonesia. It is verified this kind of agribusiness benefited its largest stakeholder, namely farmers, based on parameters such as B/C ratio, farmer's share, and marketing margin. From a macroeconomic perspective, Gerga's agribusiness also can solve macroeconomic problems such as poverty, unemployment, basic needs, and regional minimum wages.
Precaution Strategy of Moral Hazard Practice in Agricultural Insurance in Indonesia: An Approach of Soft Systems Methodology
Authors: Fadhil Rahmat , Yusuf Muhammad Yasir , Bahri T. Saiful , Maulana Hafiizh , Fakhrurrazi Fakhrurrazi
Published: December 2021

This paper uses Soft Systems Methodology (SSM) to formulate strategies to prevent moral hazard acts in agricultural insurance in Indonesia. Agricultural insurance takes place, mainly, through Rice Crop Insurance and Cattle Insurance. Generally, the strategies that can be performed to minimize moral hazard practice in agricultural insurance programs are: developing the capacity of human resources, improving field communication, enforcing penalties, institutional strengthening, and adding new products through Islamic agricultural insurance. Specifically, this paper proposes that the prevention of moral hazard practices can be done by implementing Islamic agricultural insurance systems with the concept of risk-sharing instead of risk transfer.
La Suprema Corte de Justicia de México ante la penalización del aborto: una valoración de urgencia
Authors: Revenga Sánchez Miguel , Quiñones Andrade Rocío Guadalupe
Published: December 2021

El artículo analiza las recientes decisiones de la Suprema Corte de Justicia de la Nación mexicana sobre la inconstitucionalidad de aquellas regulaciones estatales que penalizan de manera absoluta el aborto. Expone los argumentos de la Corte y se plantea el problema de los efectos que pueden tener estas sentencias, teniendo en cuenta que son bastantes los Estados de la Unión que tendrán que introducir reformas legislativas para adaptarse a lo establecido por esta Corte Constitucional.
El principio constitucional de publicidad procesal y el derecho a la información
Authors: Abad Alcalá Leopoldo
Published: December 2021

La publicidad procesal posee una doble función en la Constitución española: como garantía para el justiciable (art. 24 CE) y como principio de actuación del Poder Judicial (art. 120 CE). Esta publicidad procesal es desarrollada de forma mediata en las sociedades contemporáneas por los medios de comunicación a través del ejercicio del derecho a la información. Sin embargo, la frecuente instauración del secreto de sumario y otras limitaciones procesales introduce un elemento de conflictividad en las relaciones entre Poder Judicial y medios de comunicación. La declaración sin modulaciones del secreto sumarial implica su reiterado incumplimiento, requiriéndose una nueva normativa que permita matizar dicho secreto en función de diversas circunstancias y reconduzca la relación en el Poder Judicial y los medios de comunicación desde el reconocimiento de la importante y simbiótica labor desarrollada por ambos en los sistemas democráticos.
Perfil dos novos padres à luz do Papa Francisco: uma análise teológica do cenário ministerial a partir do exótico
Authors: Boccato Almeida André Luiz , Biancão Ronivalder , Vieira Camargo de Moraes Karolayne Maria
Published: December 2021

O presente artigo propõe-se a analisar o perfil dos novos padres à luz do ensinamento do Papa Francisco. Para isso, se servirá de uma constatação a respeito de alguns cenários de Igreja existentes no Brasil a partir da prática exótica dentro do ministério ordenado. Deste modo, a reflexão, inicialmente, partirá de uma análise indutiva onde se compreenderá o contexto segundo o qual moldam-se os perfis dos novos padres. Posteriormente, serão retomadas as fontes bíblico-teológicas que iluminam o verdadeiro sentido do ministério ordenado, para salientar o real significado do serviço. Enfim, será proposto, a partir do pontificado de Francisco, evidenciar a centralidade desta vocação no perfil de um novo padre, com “cheiro de ovelha”, expressão cunhada pelo próprio pontífice. Esta reflexão, de cunho propositivo, visa denunciar e problematizar uma prática ministerial que, em tempos de crise de identidade, exposição midiática e projeção narcisista, se distancia da práxis do cuidado, escuta e acompanhamento real dos cristãos na comunidade.
Os “padres novos” como fruto do embaralhamento de paradigmas eclesiais
Authors: Godoy Manoel José
Published: December 2021

Este estudo faz um breve relatório e uma análise dos dados relativos às três questões que encerram o terceiro bloco de perguntas do questionário aplicado na pesquisa de campo em busca do perfil dos “padres novos” no Brasil, relativas a como está a vida e a relação do presbitério entre seus membros e com o bispo (questão 8), como veem os presbíteros em geral (questão 9) e qual o modo mais adequado de um presbítero vestir-se hoje (questão 10). A abordagem começa por um breve relatório dos dados, seguido de uma análise dos mesmos, enfocando as mudanças que a Igreja católica vem sofrendo desde a realização do Concilio Vaticano II (1962-1965). Para isso, toma como referencial, por um lado, o perfil dos padres das décadas de 1970/80, alinhados à perspectiva sócio pastoral “evangelização/libertação” e, por outro, o perfil dos “padres novos”, que se remetem à perspectiva “institucional/carismática”. Constata que a renovação conciliar levou a Igreja de uma postura apologética frente ao mundo a uma relação de diálogo e serviço, mas por pouco tempo, pois sofreu um revés enorme nas décadas posteriores, com repercussões profundas no ser e agir dos presbíteros. Na atualidade, o novo pontificado de Francisco resgata a renovação conciliar, mas não sem reticencias e até mesmo com a oposição dos segmentos alinhados à perspectiva “institucional/carismática”.
Magnetic properties of directional textured dysprosium foils for cryogenic undulator
Authors: He Yong-Zhou , Wang Jie ,   Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201204, China,   Mianyang Westmag Magnetism & Electricity Co., Ltd, China Electronics Technology Group, Mianyang 621000, China
Published: December 2021

Directional textured dysprosium foils are fabricated by rapid solidification and sequential cold rolling, and the influences of their thickness values and magnetic structures on magnetic properties are analyzed and studied. The results show that magnetic properties of cold-rolled dysprosium foils are better than those of rapid solidification dysprosium foils, and the magnetization and permeability for each of the cold-rolled dysprosium foils are related to the thickness and temperature. Below Curie temperature, the cold-rolled dysprosium foils have obvious soft magnetic properties in a temperature range from 77 K to 4.2 K, the saturation magnetization for each of cold-rolled dysprosium foils increases by 5%－8%, and the saturation magnetization of 0.15-mm-thick cold-rolled dysprosium foil arrives at 2880 kA/m at 4.2 K, and the maximum permeability of cold-rolled 0.10-mm-thick dysprosium foil approaches to 30. The cryogenic magnetization of cold-rolled dysprosium foil with a strong external magnetic field is higher than that of conventional Co-V-Fe below 85 K. The cryogenic magnetic properties of textured dysprosium foils are related to the oxygen content and the orientation degree of (0001) crystal plane. The present study lays the foundation of technology and principle for preparing the chunky directional textured dysprosium soft magnet for cryogenic undulator.
Acoustic cavitation characteristics of bubble in compressible liquid
Authors: Zheng Ya-Xin , Naranmandula  ,   College of Mathematics and Physics, Inner Mongolia University for Nationalities, Tongliao 028043, China
Published: December 2021

The newly proposed Gilmore-NASG model is used to study the acoustic cavitation characteristics of bubble in compressible liquid under the boundary condition of considering the compressible effect of the liquid, and comparison is made between the results calculated by the Gilmore-NASG model and original KM-VdW model without considering the mass exchange, chemical reaction and heat exchange between the gas in the bubble and the surrounding liquid. The results suggest that, compared with the KM-VdW model, the Gilmore-NASG model which employs a new equation of state to describe the gas, liquid and variations of liquid density and sound velocity due to compressibility, can give a larger compression ratio of cavitation bubble, a deeper collapse depth, higher temperature and pressure peaks. This is mainly because that the co-volume of argon molecule in the NASG equation of state is smaller than that in the VdW equation of state and the effect of the co-volume of water molecule is considered in the NASG equation of state, that is, the Gilmore-NASG model gives more comprehensive consideration to the liquid compressibility. When the bubble collapses violently, the Gilmore-NASG model takes into account the changes of sound velocity caused by the compressibility of the liquid at the bubble wall, effectively avoid the possibility of abnormal increase in the Mach number of the liquid at the bubble wall. With the increase in the driving sound pressure amplitude, the difference between the results given by the two models more and more significantly and the temperature and pressure peaks in the bubble given by the Gilmore-NASG model increase more significantly. With the rise of driving frequency, the difference between the results given by the two models gradually decreases and tends to be consistent under the high-frequency excitation. This indicates that the temperature and pressure in the bubble may arrive at higher values considering the compressibility of the medium caused by the co-volume changes of gas and surrounding liquid at different temperatures and pressures. In the meantime, the Gilmore-NASG model can accurately predict the changes in density, pressure and temperature of the liquid at the bubble wall as well as sound velocity, so this model has advantages in the study of bubble cavitation characteristics under high pressure and the effect of surrounding liquid on bubble cavitation characteristics. There will be important applications for the research on specific issues such as high-intensity focused ultrasound, shock wave lithotripsy treatment and sonochemistry.
Modifications of the Goguen's intuitionistic fuzzy implication
Authors:   Systems Research Institute, Polish Academy of Sciences, Kacprzyk Janusz ,   Warsaw School of Information Technology, Čunderlíková Katarína ,   Mathematical Institute, Slovak Academy of Sciences, Angelova Nora ,   Faculty of Mathematics and Informatics, Sofia University, Atanassov Krassimir T. ,   Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences
Published: December 2021

On the basis of the Goguen’s intuitionistic fuzzy implication, seven of its modifications are constructed. Some of their basic properties are studied. The negations, generated by these implications are introduced and some of their properties are also described.
A new type of intuitionistic fuzzy modal operators over intuitionistic fuzzy pairs
Authors:   Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Atanassov Krassimir T.
Published: December 2021

In the paper, two intuitionistic fuzzy modal operators from a new type are introduced over intuitionistic fuzzy pairs. Some of the basic properties of the new operators are formulated and checked.
Categorical properties of intuitionistic fuzzy groups
Authors:   P. G. Department of Mathematics, D.A.V. College, Sharma P. K. , Chandni  ,   Lovely Professional University, Phagwara, India
Published: December 2021

The category theory deals with mathematical structures and relationships between them. Categories now appear in most branches of mathematics and in some areas of theoretical computer science and mathematical physics, and acting as a unifying notion. In this paper, we study the relationship between the category of groups and the category of intuitionistic fuzzy groups. We prove that the category of groups is a subcategory of category of intuitionistic fuzzy groups and that it is not an Abelian category. We establish a function β : Hom(A, B) → [0; 1] × [0; 1] on the set of all intuitionistic fuzzy homomorphisms between intuitionistic fuzzy groups A and B of groups G and H, respectively. We prove that β is a covariant functor from the category of groups to the category of intuitionistic fuzzy groups. Further, we show that the category of intuitionistic fuzzy groups is a top category by establishing a contravariant functor from the category of intuitionistic fuzzy groups to the lattices of all intuitionistic fuzzy groups.
Intuitionistic fuzzy evaluation of artificial neural network model
Authors:   “Prof. Dr. Assen Zlatarov” University, Petkov Todor , Bureva Veselina ,   “Prof. Dr. Assen Zlatarov” University, Popov Stanislav ,   “Prof. Dr. Assen Zlatarov” University
Published: December 2021

In this paper a method that evaluates a trained artificial neural network is presented. The learning type of an artificial neural network is supervised learning which requires labeled input training vectors. Labeled medical data is provided to train the network, where the labels can either be 1 if the person is alive, or 0 if the person has deceased. The data is divided into training and validation vectors. The validation input vectors are used to evaluate the model and the results are summarized by using intuitionistic fuzzy values.
Slowly evolving dopaminergic activity modulates the moment-to-moment probability of reward-related self-timed movements
Authors: Hamilos Allison E , Spedicato Giulia , Hong Ye , Sun Fangmiao , Li Yulong , Assad John A
Published: December 2021

Clues from human movement disorders have long suggested that the neurotransmitter dopamine plays a role in motor control, but how the endogenous dopaminergic system influences movement is unknown. Here, we examined the relationship between dopaminergic signaling and the timing of reward-related movements in mice. Animals were trained to initiate licking after a self-timed interval following a start-timing cue; reward was delivered in response to movements initiated after a criterion time. The movement time was variable from trial-to-trial, as expected from previous studies. Surprisingly, dopaminergic signals ramped-up over seconds between the start-timing cue and the self-timed movement, with variable dynamics that predicted the movement/reward time on single trials. Steeply rising signals preceded early lick-initiation, whereas slowly rising signals preceded later initiation. Higher baseline signals also predicted earlier self-timed movements. Optogenetic activation of dopamine neurons during self-timing did not trigger immediate movements, but rather caused systematic early-shifting of movement initiation, whereas inhibition caused late-shifting, as if modulating the probability of movement. Consistent with this view, the dynamics of the endogenous dopaminergic signals quantitatively predicted the moment-by-moment probability of movement initiation on single trials. We propose that ramping dopaminergic signals, likely encoding dynamic reward expectation, can modulate the decision of when to move.
The Cost of Isolation
Authors: Boamah Sheila A. , Dal Bello-Haas Vanina , Weldrick Rachel
Published: December 2021

Background: Recent research has found that family (e.g., informal, unpaid) caregivers to those in long-term care can experience significant risk of social isolation, a harmful social outcome linked to poor health and wellbeing. For many, the COVID-19 global pandemic has been a time marked by challenges that have exacerbated existing risk of social isolation and has likely impacted mental health and wellbeing among caregivers. As such, this paper outlines a protocol to investigate the extent to which the COVID-19 pandemic has impacted the psychological health and well-being of family caregivers of people living in residential long-term care.

Methods/Design: A descriptive phenomenological design and photovoice methodology will be used alongside focus groups to capture the perspectives and voices of 15-20 family caregivers. Data will be analyzed thematically, and themes will be developed collaboratively alongside participants. A secondary analysis will be guided by a cumulative inequality lens to consider how the COVID-19 pandemic has differentially affected caregivers.

Discussion: The results will fill a significant gap in the existing literature on caregiver isolation during this pandemic and inform the development and/or refinement of caregiver supports.
Electroencephalogram-derived pain index for evaluating pain during labor
Authors: Sun Liang , Zhang Hong , Han Qiaoyu , Feng Yi
Published: December 2021

Background

The discriminative ability of a point-of-care electroencephalogram (EEG)-derived pain index (Pi) for objectively assessing pain has been validated in chronic pain patients. The current study aimed to determine its feasibility in assessing labor pain in an obstetric setting.

Methods

Parturients were enrolled from the delivery room at the department of obstetrics in a tertiary hospital between February and June of 2018. Pi values and relevant numerical rating scale (NRS) scores were collected at different stages of labor in the presence or absence of epidural analgesia. The correlation between Pi values and NRS scores was analyzed using the Pearson correlation analysis. The receiver operating characteristic (ROC) curve was plotted to estimate the discriminative capability of Pi to detect labor pain in parturients.

Results

Eighty paturients were eligible for inclusion. The Pearson correlation analysis exhibited a positive correlation between Pi values and NRS scores in parturients (r = 0.768, P < 0.001). The ROC analysis revealed a cut-off Pi value of 18.37 to discriminate between mild and moderate-to-severe labor pain in parturients. Further analysis indicated that Pi values had the best diagnostic accuracy reflected by the highest area under the curve (AUC) of 0.857, with a sensitivity and specificity of 0.767 and 0.833, respectively, and a Youden index of 0.6. Subgroup analyses further substantiated the correlations between Pi values and NRS scores, especially in parturients with higher pain intensity.

Conclusion

This study indicates that Pi values derived from EEGs significantly correlate with the NRS scores, and can serve as a way to quantitatively and objectively evaluate labor pain in parturients.
Graduação em Ciências Contábeis a distância: dando início à discussão.
Authors: Laffin Marcos , Portella Anastácia
Published: December 2021

As políticas de expansão do Ensino Superior propõem a oferta de graduação também na modalidade a distância. O curso de Ciências Contábeis da Universidade Federal de Santa Catarina (UFSC) apresentou inserção nessa modalidade de formação por meio de um projeto específico. O objetivo deste artigo é levantar informações sobre a oferta do curso de graduação em Ciências Contábeis na modalidade a distância e a sua articulação com a formação profissional, procurando correlacionar a demanda e a oferta do curso. O estudo se caracteriza como exploratório e foi realizado por meio do levantamento de dados da pesquisa documental e bibliográfica. Conclui-se que projetos de oferta no ensino superior tais como os de educação a distância, não podem ser pensados como cursos colocados à disposição de contextos considerados ingênuos pela carência da oferta e da formação profissional. Pelo contrário, devem ser realizados a partir de estruturas de planejamento educacional com a finalidade de qualificar a oferta, sem que esta desqualifique os processos de democratização da educação.
Reorganização Societária Atípica: Impactos Contábeis e Tributários do DROP DOWN no Brasil
Authors: Assumpção Debora Skibinski , Kronbauer Clovis Antonio , Alves Diego Saldo
Published: December 2021

O presente estudo tem o objetivo de analisar os impactos contábeis e tributários de uma reorganização societária conhecida como DROP DOWN. Muito comum nos Estados Unidos no meio empresarial, ela é caracterizada pelo aumento de capital que uma empresa faz em outra, na qual transfere bens, direitos e/ou obrigações em troca da participação societária com controle acionário. Sem previsão legal no direito societário brasileiro, mas já sendo realizada em algumas empresas brasileiras como uma opção de reestruturação societária.

O DROP DOWN se assemelha a cisão em alguns aspectos, mas sem a redução do capital social ou extinção da empresa cindida, por isso alguns autores aqui no Brasil a denominaram de “cisão branca”.

A metodologia concentrou-se em bases documentais, e assim, o estudo foi realizado por meio de buscas em sites jurídicos, no site EBSCO, biblioteca do STF, artigos e livros jurídicos, onde constassem temas ligados à reestruturação ou reorganização societária por intermédio da combinação de negócio que envolvessem a operação de drop down . Os resultados obtidos foram satisfatórios, pois demonstram que mesmo não sendo divulgada e ou conhecida em nosso país, o drop down vem ocorrendo em muitas estratégias de negócios em empresas brasileiras; e, concluiu-se que por não haver previsão legal para esse modelo de reestruturação societária em nosso país, todas as suas causas e efeitos são discutíveis judicialmente, se por acaso as entidades federais ou estaduais sentirem-se prejudicadas.
A ADOÇÃO DO CPC PME – CONTABILIDADE PARA PEQUENAS E MÉDIAS EMPRESAS
Authors: Teles de Araújo Faria Camilla , Mendes da Silva Denise
Published: December 2021

Com a crescente abertura da economia brasileira aos mercados internacionais, surge a necessidade de convergência para normas internacionais de contabilidade. O CPC (Comitê de Pronunciamentos Contábeis) é o órgão que centraliza a emissão de pronunciamentos técnicos, interpretações e orientações técnicas contábeis no Brasil em conformidade com o conjunto de normas contábeis internacionais. Em 1º de janeiro de 2010 entrou em vigor o CPC PME – Contabilidade para Pequenas e Médias Empresas – que dispõe sobre a forma como devem ser guiadas as práticas contábeis destas empresas. O presente estudo envolve uma pesquisa de caráter descritivo e quantitativo, com utilização da técnica de levantamento por meio da aplicação de questionários, que busca identificar se os contadores das pequenas e médias empresas da cidade de Uberlândia/MG estão adotando o CPC PME na elaboração das demonstrações contábeis. A amostra é constituída por 84 entidades prestadoras de serviços contábeis. Os resultados demonstraram que apenas 15% dos contadores da amostra afirmam utilizar o CPC PME, porém há uma fragilidade no conhecimento destes profissionais a respeito da norma.
UM ESTUDO BIBLIOMÉTRICO DO CONGRESSO BRASILEIRO DE CUSTOS NO LAPSO TEMPORAL DE 2011 A 2013
Authors: Santos Geovane Camilo , Silva Laise Teixeira
Published: December 2021

A presente pesquisa visou apresentar o perfil dos artigos aprovados para publicação nos anais do Congresso Brasileiro de Custos, entre os anos de 2011 a 2013, sendo utilizado a bibliometria. Os principais pontos abordados foram: número de trabalhos aprovados, gêneros de autores, autores mais prolíferos, faculdades mais prolíferas, abordagem mais usada e maior número de palavras-chave. A metodologia do presente trabalho foi bibliográfica e documental para os procedimentos, descritiva para objetivo e qualitativa e quantitativa para a abordagem. Os resultados apontam que o número de artigos publicados no lapso temporal não apresenta uniformidade, constatou-se a predominância de autores do sexo masculino em relação ao feminino e que os autores mais prolíferos foram: Alceu Souza, Altair Borgert, Carlos Eduardo Facin Lavarda, Fabrícia Silva da Rosa, Ilse Maria Beuren e Sérgio Murilo Petri, com 8 artigos cada um. A faculdade mais prolífera foi a UFSC com 206 publicações e no trato da metodologia o mais usual é não mencionar a abordagem. Na análise do número de palavras-chave verificou que o mais usual são 3 correspondendo a 83,41% dos artigos.
Male triploid oysters of Crassostrea gigas exhibit defects in mitosis and meiosis during early spermatogenesis
Authors: Maillard Floriane , Elie Nicolas , Villain‐Naud Nadège , Lepoittevin Mélanie , Martinez Anne‐Sophie , Lelong Christophe
Published: December 2021

The Pacific oyster, Crassostrea gigas, is a successive irregular hermaphrodite mollusk which has an annual breeding cycle. Oysters are naturally diploid organisms, but triploid oysters have been developed for use in shellfish aquaculture, with the aim of obtaining sterile animals with commercial value. However, studies have shown that some triploid oysters are partially able to undergo gametogenesis, with numerous proliferating cells closed to diploids (3n alpha) or a partial one with an accumulation of locked germ cells (3n beta). The aim of our study therefore was to understand the regulation of spermatogenesis in both groups of triploid oysters (alpha and beta) from the beginning of spermatogenesis, during mitosis and meiosis events. Our results demonstrate that the reduced spermatogenesis in triploids results from a deregulation of the development of the germinal lineage and the establishment of the gonadal tract led by a lower number of tubules. Morphological cellular investigation also revealed an abnormal condensation of germ cell nuclei and the presence of clear patches in the nucleoplasm of triploid cells, which were more pronounced in beta oysters. Furthermore, studies of molecular and cellular regulation showed a downregulation of mitotic spindle checkpoint in beta oysters, resulting in disturbance of chromosomal segregation, notably on spindle assembly checkpoint involved in the binding of microtubules to chromosomes. Taken together, our results suggest that the lower reproductive ability of triploid oysters may be due to cellular and molecular events such as impairment of spermatogenesis and disruptions of mitosis and meiosis, occurring early and at various stages of the gametogenetic cycle.
Validation of automated complex head and neck treatment planning with pencil beam scanning proton therapy
Authors: Hedrick Samantha Grace , Petro Scott , Ward Alex , Morris Bart
Published: December 2021

Background

Pencil beam scanning (PBS) proton therapy offers dosimetric advantages for several treatment sites, including head and neck (H&N). However, to achieve the optimal target coverage and robustness, these plans can be complex and time consuming to develop and optimize. Automating the treatment planning process can ensure a high‐quality and standardized plan, reduce burden to the planner, and decrease time‐to‐treatment. We utilized in‐house scripting to automate a four‐field multi‐field optimization (MFO) H&N planning technique.

Methods and materials

Ten bilateral H&N patients were planned in RayStation v6 with a four‐field modified‐X beam configuration using MFO planning. Automation included creation of avoidance structures to control spot placement and development of standardized beams, PBS spot settings, robust optimization objectives, and patient‐specific predicted planning constraints. Each patient was planned both with and without automation to evaluate differences in planning time, perceived effort and plan quality, plan robustness, and OAR sparing.

Results

On average, scripted plans required 3.2 h, compared to 4.3 h without the script. There was no difference in target coverage or plan robustness with or without automation. Automation significantly reduced mean dose to the oral cavity, parotids, esophagus, trachea, and larynx. Perceived effort was scaled from 1 (minimum effort) to 100 (maximum effort), and automation reduced perceived effort by 42% (p < 0.05). Two non‐scripted plans required re‐planning due to errors.

Conclusions

Automation of this multi‐beam, the MFO proton planning process reduced planning time and improved OAR sparing compared to the same planning process without scripting. Scripting generation of complex structures and planning objectives reduced burden on the planner. With most current treatment planning software, this automation is simple to implement and can standardize quality of care across all treatment planners.
Implication of the Nociplastic Features for Clinical Diagnosis of Fibromyalgia: Development of the Preliminary Nociplastic‐Based Fibromyalgia Features (NFF) Tool
Authors: Ghavidel‐Parsa Banafsheh , Bidari Ali , Atrkarroushan Zahra , Khosousi Mohammad‐Javad
Published: December 2021

Objective

Nociplastic concept incorporates a broad continuum of pain phenotypes shared with clinical peculiarity. This study aimed to develop and validate a diagnostic tool, the preliminary Nociplastic‐based Fibromyalgia Features (NFF), to detect fibromyalgia (FM) in patients with chronic pain.

Methods

Items requiring yes or no responses and relating to the most relevant clinical nociplastic pain (NP) features of FM were compiled by a group of expert rheumatologists. The provisional list was tested in a prospective study on 185 consecutive patients with chronic pain (126 patients with FM and 59 patients with non‐FM non‐inflammatory chronic pain) diagnosed based on expert decision. Identification of the most discriminant combinations of items for FM and the calculation of their sensitivity and specificity were based on both univariate and multivariate (stepwise logistic regression) analyses. All participants were investigated through the final NFF, the 2011 American College of Rheumatology (ACR) criteria, and the 2016 ACR criteria. NFF performance was assessed with receiver operating characteristic curve analysis.

Results

Based on multivariate analyses, we retained only seven items in the final version of the NFF. A cut‐off score of 4 (corresponding to the number of positive items) gave the highest rate of correct identification of patients (85%), with a sensitivity of 82% and a specificity of 91%. The NFF showed the highest concordance rate with expert diagnosis (85%) and the lowest value (77%) with the ACR 2016 criteria.

Conclusion

The preliminary NFF with respect to the various aspects of NP showed good performance for detection of the FM in the clinical setting. This tool may provide a more pragmatic approach to the timely diagnosis of FM.
On‐Demand Editing of Surface Properties of Microstructures Made by 3D Direct Laser Writing via Photo‐Mediated RAFT Polymerization
Authors: Wu Xingyu , Gross Bryan , Leuschel Benjamin , Mougin Karine , Dominici Sébastien , Gree Simon , Belqat Mehdi , Tkachenko Vitalii , Cabannes‐Boué Benjamin , Chemtob Abraham , Poly Julien , Spangenberg Arnaud
Published: December 2021

Recently, photo‐controlled reversible addition‐fragmentation chain transfer (RAFT) polymerization has been successfully applied in digital light processing 3D printing. It provides a convenient way to tune the surface properties of the 3D printed object. However, so far, 3D micro‐ and nanostructures and reconfigurations based on photo‐induced RAFT polymerization have not been presented. In this work, one macro‐photoiniferter, synthesized by photo‐controlled RAFT polymerization is applied, to 3D direct laser writing. Thanks to the exquisite spatial control of the photoreaction, 3D microstructures with feature sizes of around 500 nm are successfully obtained. Taking advantage of the presence of dormant polymeric RAFT agents, photo‐induced post‐modification of the printed microstructures is highlighted via the elaboration of multi‐chemistry patterns including thermo‐responsive ones. These results open new perspectives in multi‐material and 4D micro‐printing.
Quasi‐Single Crystalline Cuprous Oxide Wafers via Stress‐Assisted Thermal Oxidation for Optoelectronic Devices
Authors: Xiao Meng , Gui Pengbin , Dong Kailian , Xiong Liangbin , Liang Jiwei , Yao Fang , Li Wenjing , Liu Yongjie , Li Jiashuai , Ke Weijun , Tao Chen , Fang Guojia
Published: December 2021

P‐type semiconductor cuprous oxide (Cu2O) offers promising optoelectronic applications such as solar cells and photodetectors owing to its considerable absorption coefficients and high carrier mobility. However, polycrystalline Cu2O films with low carrier mobility resulting from excessive grain boundaries and structure disorder fail to meet the demands for these optoelectronic applications. Here a stress‐assisted thermal oxidation method to fabricate p‐type <110>‐textured quasi‐single crystalline Cu2O (c‐Cu2O) wafers with centimeter‐scale grains is developed. It is found that strain energy induced by thermal contact stress plays a critical role in crystal growth. The resultant <110>‐textured quasi‐single c‐Cu2O wafers exhibit excellent crystallinity with rocking curve having a low full width at half maximum of 0.022°, a low defect density of 2 × 1011 cm−3, a high mobility exceeding 100 cm2 V−1 s−1, and a long minority lifetime of 98.5 µs. Such quasi‐single c‐Cu2O wafers lead to efficient solar cells with an open‐circuit voltage of 0.95 V and highly responsive photodetectors with superior cycling stability. These results indicate not only the advancement of fabricating high‐quality Cu2O wafers upon controllable methodology but also the promising optoelectronic applications using p‐type metal oxide semiconductors.
Hofmeister Effect and Electrostatic Interaction Enhanced Ionic Conductive Organohydrogels for Electronic Applications
Authors: Wu Yinghong , Mu Yijie , Luo Yang , Menon Carlo , Zhou Zhiwen , Chu Paul K. , Feng Shien‐Ping
Published: December 2021

The emerging cryoprotectant replacement method endows hydrogels with nondrying and antifreezing properties, but the low conductivity still limits wider electronic applications. In this work, the Hofmeister effect and electrostatic interaction are introduced to improve the conductivity of organohydrogels and their enhancement mechanism are studied in depth. The Hofmeister effect mainly influences the physical properties, such as the pore structure and mechanical strength, which subsequently impacts ion transfer during the solvent replacement process. The lithium and sodium bonds formed by the electrostatic interaction play a more important role in the conductivity of organohydrogels and an overall picture is presented based on the synergistic enhancement of the Hofmeister effect and electrostatic interaction to achieve highly ionic conductive organohydrogels. The champion organohydrogels are applied as soft ionic conductors and antireflective layers in triboelectric, photovoltaic, and thermoelectric applications. The proposed mechanism advances the understanding of the contribution of ions to organohydrogels for wearable electronics.
Semiconducting MOF@ZnS Heterostructures for Photocatalytic Hydrogen Peroxide Production: Heterojunction Coverage Matters
Authors: Liu Chao , Bao Tong , Yuan Ling , Zhang Chaoqi , Wang Jing , Wan Jingjing , Yu Chengzhong
Published: December 2021

Construction of semiconducting metal‐organic framework based heterostructures is emerging as a promising strategy for enhancing their photocatalytic performances. Here, tetrapod‐like NH2‐MIL‐125@ZnS heterostructures with tunable heterojunction coverage and well‐matched band structure are synthesized as photocatalysts. When used for photocatalytic O2 reduction reaction, a heterojunction coverage of ≈45.1% leads to the best performance with a hydrogen peroxide production rate of ≈120 mm g−1 h−1, outperforming control samples with either larger or smaller heterojunction coverages and most reported MOF based photocatalysts in similar reaction systems.
Hydrogel Microparticle‐Templated Anti‐Solvent Crystallization of Small‐Molecule Drugs
Authors: Bora Meghali , Hsu Myat Noe , Khan Saif A , Doyle Patrick S
Published: December 2021

Conventional formulation strategies for hydrophobic small‐molecule drug products frequently include mechanical milling to decrease active pharmaceutical ingredient (API) crystal size and subsequent granulation processes to produce an easily handled powder. A hydrogel‐templated anti‐solvent crystallization method is presented for the facile fabrication of microparticles containing dispersed nanocrystals of poorly soluble API. Direct crystallization within a porous hydrogel particle template yields core–shell structures in which the hydrogel core containing API nanocrystals is encased by a crystalline API shell. The process of controllable loading (up to 64% w/w) is demonstrated, and tailored dissolution profiles are achieved by simply altering the template particle size. API release is well described by a shrinking core model. Overall, the approach is a simple, scalable and potentially generalizable method that enables novel means of independently controlling both API crystallization and excipient characteristics, offering a “designer” drug particle system.
Achieving Efficient NIR‐II Type‐I Photosensitizers for Photodynamic/Photothermal Therapy upon Regulating Chalcogen Elements
Authors: Wen Kaikai , Tan Hui , Peng Qian , Chen Hao , Ma Han , Wang Lu , Peng Aidong , Shi Qinqin , Cai Xiaodong , Huang Hui
Published: December 2021

Second near‐infrared (NIR‐II) window type‐I photosensitizers have intrinsic advantages in photodynamic/photothermal therapy (PDT/PTT) of some malignant tumors with deep infiltration, large size, complicated location, and low possibility of surgery/radiotherapy. Herein, three chalcogen‐element‐based donor–acceptor‐type semiconducting polymers (poly[2,2″‐((E)‐4,4″‐bis(2‐octyldodecyl)‐[6,6″‐bithieno[3,2‐b]pyrrolylidene]‐5,5″(4H,4″H)‐dione)‐alt‐2,5‐(thiophene)] (PTS), poly[2,2″‐((E)‐4,4″‐bis(2‐octyldodecyl)‐[6,6″‐bithieno[3,2‐b]pyrrolylidene]‐5,5″(4H,4″H)‐dione)‐alt‐2,5‐(selenophene)] (PTSe), and poly[2,2″‐((E)‐4,4″‐bis(2‐octyldodecyl)‐[6,6″‐bithieno[3,2‐b]pyrrolylidene]‐5,5″(4H,4′H)‐dione)‐alt‐2,5‐(tellurophene)] (PTTe)) are synthesized and fully characterized, demonstrating strong absorption in the NIR‐II region. Upon adjusting the chalcogen elements, the intramolecular charge‐transfer characteristics and the heavy‐atom effect are tuned to enhance the intersystem crossing rate, improving the photodynamic effect. Moreover, the energy levels and Gibbs free energies are tuned to facilitate the type‐I photodynamic process. As a result, PTTe nanoparticles (NPs) produce superoxide anion radicals (O2•−) more efficiently and demonstrate higher photothermal conversion efficiency than PTS and PTSe NPs upon NIR‐II (1064 nm) laser irradiation, exhibiting unprecedented NIR‐II type‐I PDT/PTT performance in vitro and in vivo. This work provides ideas for achieving high‐performance NIR‐II type‐I PDT/PTT semiconducting polymers for hypoxic oncotherapy.
Vertical Extrusion Cryo(bio)printing for Anisotropic Tissue Manufacturing
Authors: Luo Zeyu , Tang Guosheng , Ravanbakhsh Hossein , Li Wanlu , Wang Mian , Kuang Xiao , Garciamendez‐Mijares Carlos Ezio , Lian Liming , Yi Sili , Liao Junlong , Xie Maobin , Guo Jie , Zhou Zongke , Zhang Yu Shrike
Published: December 2021

Due to the poor mechanical properties of many hydrogel bioinks, conventional 3D extrusion bioprinting is usually conducted based on theX–Yplane, where the deposited layers are stacked in theZ‐direction with or without the support of prior layers. Herein, a technique is reported, taking advantage of a cryoprotective bioink to enable direct extrusion bioprinting in the vertical direction in the presence of cells, using a freezing plate with precise temperature control. Of interest, vertical 3D cryo‐bioprinting concurrently allows the user to create freestanding filamentous constructs containing interconnected, anisotropic microchannels featuring gradient sizes aligned in the vertical direction, also associated with enhanced mechanical performances. Skeletal myoblasts within the 3D‐cryo‐bioprinted hydrogel constructs show enhanced cell viability, spreading, and alignment, compared to the same cells in the standard hydrogel constructs. This method is further extended to a multimaterial format, finding potential applications in interface tissue engineering, such as creation of the muscle–tendon unit and the muscle–microvascular unit. The unique vertical 3D cryo‐bioprinting technique presented here suggests improvements in robustness and versatility to engineer certain tissue types especially those anisotropic in nature, and may extend broad utilities in tissue engineering, regenerative medicine, drug discovery, and personalized therapeutics.
Self‐Assembly of Strongly Amphiphilic Janus Nanoparticles into Freestanding Membranes
Authors: Mihali Voichita , Honciuc Andrei
Published: December 2021

Amphiphilic nanoparticles can adsorb at interfaces between immiscible phases and form membranes. The ability to handle nanoparticle monolayers/bilayers as freestanding membranes independently from the interfaces on which they form can be of significant practical interest. Janus nanoparticles (JNPs) could generate membranes that have tunable pore size and are amphiphilic. Here it is shown how freestanding membranes from JNPs can be generated. First, strongly amphiphilic Janus nanoparticles that generate foams in surfactant‐free conditions are synthesized. Upon drying the foam lamellae remain as freestanding membranes consisting of perfectly oriented bilayers or monolayers of JNPs, thus providing direct evidence of structural organization of amphiphiles in foam lamellae. The wet foam lamellae can be picked up on grids and upon drying generate freestanding membranes. Sturdy freestanding membranes by transferring monolayers of JNPs from the air–water interfaces onto grids with fine openings are also prepared.
Thermal Fluctuations of the Optical Properties of Nanomechanical Photonic Metamaterials
Authors: Li Jinxiang , Papas Dimitrios , Liu Tongjun , Ou Jun‐Yu , MacDonald Kevin F. , Plum Eric , Zheludev Nikolay I.
Published: December 2021

The combination of optical and mechanical resonances offers strong hybrid nonlinearities, bistability, and the ability to efficiently control the optical response of nanomechanical photonic metamaterials with electric and magnetic field. While optical resonances can be characterized in routine transmission and reflection experiments, mapping the high‐frequency mechanical resonances of complex metamaterial structures is challenging. Here, it is reported that high‐frequency time‐domain fluctuations in the optical transmission and reflection spectra of nanomechanical photonic metamaterials are directly linked to thermal motion of their components and can give information on the fundamental frequencies and damping of the mechanical modes. This is demonstrated by analyzing time‐resolved fluctuations in the transmission and reflection of dielectric and plasmonic nanomembrane metamaterials at room temperature and low ambient gas pressure. These measurements reveal complex mechanical responses, understanding of which is essential for optimization of such functional photonic materials. At room temperature the magnitude of the observed metamaterial transmission and reflection fluctuations is of order 0.1% but may exceed 1% at optical resonances.