bluuebunny/crossref_metadata_2025 huggingface dataset:
Systemic Glycemic Variation Predicts Mortality of Acute Ischemic Stroke After Mechanical Thrombectomy: A Prospective Study Using Continuous Glucose Monitoring
Authors: Deng Jiangshan , Li Ling , Cao Fengya , Wang Feng , Wang Hongmei , Shi Hong , Shen Li , Zhao Fei , Zhao Yuwu
Published: March 2022

Objective

We investigated the association of glycemic variation with the clinical outcomes of large vessel occlusion (LVO) induced acute ischemic stroke (AIS) after mechanical thrombectomy (MT).

Methods

We recruited consecutive ischemic patients with stroke. Glucose levels were assessed through continuous glucose monitoring in 70 patients with AIS who had undergone MT. Metrics including percentages of time of glucose levels above the range, the hypoglycemic range, and the time within the range, coefficient of variation, standard deviation (SD), mean of daily differences, mean amplitude of glycemic excursion, largest amplitude of glycemic excursion, high blood glucose index, and low blood glucose index. The outcomes of this observational study were in-hospital mortality, neurological improvement during hospitalization, functional independence, and mortality at follow-up (3 months). The associations of the blood glucose metrics with outcomes were analyzed.

Results

The average period of glucose monitoring was 3.5 days, and serum glucose was recorded 728 times after MT for each person. The glycemic variation expressed in SDs was independently associated with in-hospital mortality [odds ratio (OR): 2.8, 95% confidence interval (CI): 1.276–6.145, p = 0.01] and the 3-month mortality (OR: 2.107, 95% CI: 1.013–4.382, p = 0.046) after adjusting for potential confounders. There was no association of glycemic variation with the 3-month clinical functional independence.

Conclusions

Increased systemic glycemic variation was associated with higher odds of mortality of LVO-AIS after MT.

Clinical Trial Registration

http://www.chictr.org.cn/showproj.aspx?proj=21016, identifier: ChiCTR-OOC-17012378.
Autoimmune and Paraneoplastic Chorea: A Review of the Literature
Authors: Kyle Kevin , Bordelon Yvette , Venna Nagagopal , Linnoila Jenny
Published: March 2022

Autoimmune chorea syndromes represent a vast array of paraneoplastic, parainfectious and idiopathic disorders. It is increasingly apparent that familiarity with these disorders is critically important, as they may be treatable or may be part of a syndrome requiring further work-up and monitoring. These disorders are mediated by an aberrant immunologic attack with resultant neuronal dysfunction, manifesting as chorea. These conditions are typically accompanied by other neurologic or systemic manifestations. In this review we outline the clinical features, epidemiologic factors, and delineate the specific antibodies associated with each of these autoimmune mediated disorders. We highlight up to date information regarding this heterogeneous group of disorders, including a discussion of parainfectious Sydenham's chorea; paraneoplastic syndromes associated with CRMP-5 (collapsin response mediated protein-5/CV2) and ANNA-1 (antineuronal nuclear antibody / Hu) antibodies, in addition to neuronal antibody-associated disorders including anti-NMDAR, LGI1 (leucine-rich glioma inactivated-1) and CASPR2 (contactin associated protein-2). We discuss the more recently described entities of IgLON5, which has evidence of both immunologic and degenerative pathophysiology, in addition to PDE-10A antibody-associated chorea. We also outline chorea secondary to systemic diseases including Systemic Lupus Erythematosus (SLE) and Primary Antiphospholipid Syndrome (PAPS). We provide a framework for diagnosis and treatment.
Identification of Risk Factors for Stroke in China: A Meta-Analysis of Prospective Cohort Studies
Authors: Yuan Weizhuang , Wu Bo , Lou Min , Song Bo , Han Xiang , Sheng Feng , Xu Weihai
Published: March 2022

This study aimed to identify independent risk factors for first occurrence of stroke in Chinese individuals based on prospective cohort studies. Forty prospective cohort studies assessing 1,984,552 individuals were selected for the final meta-analysis. The identified risk factors for stroke in the Chinese population included old age (RR = 1.86, 95%CI: 1.47–2.36), hypertension (RR = 2.76, 95%CI: 2.26–3.37), cardiovascular disease history (RR = 1.98, 95%CI: 1.06–3.69), chronic kidney disease (RR = 1.65, 95%CI: 1.36–2.01), diabetes mellitus (RR = 1.71, 95%CI: 1.34–2.18), metabolic syndrome (RR = 1.59, 95%CI: 1.33–1.90), hyperglycemia (RR = 1.49, 95% CI: 1.31–1.69), obesity (RR = 1.45, 95%CI: 1.29–1.63), smoking (RR = 1.42, 95% CI: 1.27–1.58), prolonged sleep time (> 7.5 h, RR = 1.44, 95%CI: 1.19–1.75), higher levels of triglyceride (RR = 1.19, 95%CI: 1.07-1.32), C-reactive protein (RR = 1.34, 95%CI: 1.07-1.69). High fruit-rich diet (RR = 0.68, 95%CI: 0.58-0.80) was associated with a lower risk of stroke. The spectrum and power of risk factors varied among different cohort inclusion years. These findings provide a comprehensive tool for the primary prevention of stroke in Chinese individuals.
Fucoidan Alleviates Renal Fibrosis in Diabetic Kidney Disease via Inhibition of NLRP3 Inflammasome-Mediated Podocyte Pyroptosis
Authors: Wang Mei-Zi , Wang Jie , Cao Dong-Wei , Tu Yue , Liu Bu-Hui , Yuan Can-Can , Li Huan , Fang Qi-Jun , Chen Jia-Xin , Fu Yan , Wan Bing-Ying , Wan Zi-Yue , Wan Yi-Gang , Wu Guo-Wen
Published: March 2022

Background: Fucoidan (FPS) has been widely used to treat renal fibrosis (RF) in patients with diabetic kidney disease (DKD); however, the precise therapeutic mechanisms remain unclear. Recently, research focusing on inflammation-derived podocyte pyroptosis in DKD has attracted increasing attention. This phenomenon is mediated by the activation of the nucleotide-binding oligomerization domain (Nod)-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome, leading to RF during DKD progression. Therefore, we designed a series of experiments to investigate the ameliorative effects of FPS on RF in DKD and the mechanisms that are responsible for its effect on NLRP3 inflammasome-mediated podocyte pyroptosis in the diabetic kidney.

Methods: The modified DKD rat models were subjected to uninephrectomy, intraperitoneal injection of streptozotocin, and a high-fat diet. Following induction of renal injury, the animals received either FPS, rapamycin (RAP), or a vehicle for 4 weeks. For in vitro research, we exposed murine podocytes to high glucose and MCC950, an NLRP3 inflammasome inhibitor, with or without FPS or RAP. Changes in the parameters related to RF and inflammatory podocyte injury were analyzed in vivo. Changes in podocyte pyroptosis, NLRP3 inflammasome activation, and activation of the adenosine monophosphate-activated protein kinase (AMPK)/mammalian target of rapamycin complex 1 (mTORC1)/NLRP3 signaling axis involved in these changes were analyzed in vivo and in vitro.

Results: FPS and RAP ameliorated RF and inflammatory podocyte injury in the DKD model rats. Moreover, FPS and RAP attenuated podocyte pyroptosis, inhibited NLRP3 inflammasome activation, and regulated the AMPK/mTORC1/NLRP3 signaling axis in vivo and in vitro. Notably, our data showed that the regulative effects of FPS, both in vivo and in vitro, on the key signaling molecules, such as p-AMPK and p-raptor, in the AMPK/mTORC1/NLRP3 signaling axis were superior to those of RAP, but similar to those of metformin, an AMPK agonist, in vitro.

Conclusion: We confirmed that FPS, similar to RAP, can alleviate RF in DKD by inhibiting NLRP3 inflammasome-mediated podocyte pyroptosis via regulation of the AMPK/mTORC1/NLRP3 signaling axis in the diabetic kidney. Our findings provide an in-depth understanding of the pathogenesis of RF, which will aid in identifying precise targets that can be used for DKD treatment.
Genetic Polymorphisms and the Clinical Response to Systemic Lupus Erythematosus Treatment Towards Personalized Medicine
Authors: Barliana Melisa Intan , Afifah Nadiya Nurul , Amalia Riezki , Hamijoyo Laniyati , Abdulah Rizky
Published: March 2022

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by a broad spectrum of clinical manifestations, an aberrant autoimmune response to self-antigens, which affect organs and tissues. There are several immune-pathogenic pathways, but the exact one is still not well known unless it is related to genetics. SLE and other autoimmune diseases are known to be inseparable from genetic factors, not only pathogenesis but also regarding the response to therapy. Seventy-one human studies published in the last 10 years were collected. Research communications, thesis publication, reviews, expert opinions, and unrelated studies were excluded. Finally, 32 articles were included. A polymorphism that occurs on the genes related to drugs pharmacokinetic, such as CYP, OATP, ABC Transporter, UGT, GST or drug-target pharmacodynamics, such as FCGR, TLR, and BAFF, can change the level of gene expression or its activity, thereby causing a variation on the clinical response of the drugs. A study that summarizes gene polymorphisms influencing the response to SLE therapy is urgently needed for personalized medicine practices. Personalized medicine is an effort to provide individual therapy based on genetic profiles, and it gives better and more effective treatments for SLE and other autoimmune disease patients.
Therapeutic Drug Monitoring of Anti-Thymocyte Globulin in Allogeneic Stem Cell Transplantation: Proof of Concept
Authors: Meesters-Ensing J.I. , Admiraal R. , Ebskamp L. , Lacna A. , Boelens J. J. , Lindemans C. A. , Nierkens S.
Published: March 2022

Anti-thymocyte globulin (ATG), a polyclonal antibody, is used in allogeneic hematopoietic cell transplantation (HCT) to prevent graft-vs.-host-disease (GvHD) and graft failure (GF). Overexposure to ATG leads to poor early T-cell recovery, which is associated with viral infections and poor survival. Patients with severe inflammation are at high risk for GF and GvHD, and may have active infections warranting swift T-cell recovery. As ATG exposure may be critical in these patients, individualized dosing combined with therapeutic drug monitoring (TDM) may improve outcomes. We describe the individualized dosing approach, an optimal sampling scheme, the assay to measure the active fraction of ATG, and the workflow to perform TDM. Using a previously published population pharmacokinetic (PK) model, we determine the dose to reach optimal exposures associated with low GvHD and rejection, and at the same time promote T-cell recovery. Based on an optimal sampling scheme, peak and trough samples are taken during the first 3 days of once-daily dosing. The fraction of ATG able to bind to T-cells (active ATG) is analyzed using a bio-assay in which Jurkat cells are co-cultured with patient’s plasma and the binding is quantified using flow cytometry. TDM is performed based on these ATG concentrations on the third day of dosing; subsequent doses can be adjusted based on the expected area under the curve. We show that individualized ATG dosing with TDM is feasible. This approach is unique in the setting of antibody treatment and may result in better immune reconstitution post-HCT and subsequently better survival chances.
Dopamine Homeostasis Imbalance and Dopamine Receptors-Mediated AC/cAMP/PKA Pathway Activation are Involved in Aconitine-Induced Neurological Impairment in Zebrafish and SH-SY5Y Cells
Authors: Zhou Jie , Peng Cheng , Li Qiuju , Yan Xiaoyu , Yang Liang , Li Mengting , Cao Xiaoyu , Xie Xiaofang , Chen Dayi , Rao Chaolong , Huang Sizhou , Peng Fu , Pan Xiaoqi
Published: March 2022

Aconitine is one of the main bioactive and toxic ingredients of Aconitum species. Increasingly, aconitine has been reported to induce neurotoxicity. However, whether aconitine has effects on the dopaminergic nervous system remains unclear. In this study, zebrafish embryos at 6-days postfertilization were exposed to aconitine at doses of 0.5, 1, and 2 μM for 24 h, and SH-SY5Y cells were treated with 50, 100, and 200 μM of aconitine for 24 h. Results demonstrated that aconitine treatment induced deformities and enhanced the swimming behavior of zebrafish larvaes. Aconitine exposure suppressed cell proliferation and increased the number of reactive oxygen species and apoptosis in zebrafish larvaes and SH-SY5Y cells. Aconitine altered the levels of dopamine and its metabolites by regulating the expression of genes and proteins related to dopamine synthesis, storage, degradation, and reuptake in vivo and in vitro. Moreover, aconitine activated the AC/cAMP/PKA pathway by activating the dopamine D1 receptor (D1R) and inhibiting the dopamine D2 receptor (D2R) to disturb intracellular calcium homeostasis, eventually leading to the damage of nerve cells. Furthermore, the D1R antagonist SCH23390 and D2R agonist sumanirole pretreatment effectively attenuated the excitatory state of larvaes. Sumanirole and PKA antagonist H-89 pretreatment effectively decreased intracellular Ca2+ accumulation induced by aconitine in vivo. SCH23390 and sumanirole also reduced aconitine-induced cytotoxicity by inhibiting the AC/cAMP/PKA pathway in vitro. These results suggested that dopamine homeostasis imbalance and dopamine receptors (DRs)-mediated AC/cAMP/PKA pathway activation might be vital mechanisms underlying aconitine-induced neurological injury.
Silicon Application Differentially Modulates Root Morphology and Expression of PIN and YUCCA Family Genes in Soybean (Glycine max L.)
Authors: Tripathi Pooja , Tayade Rupesh , Mun Bong-Gyu , Yun Byung-Wook , Kim Yoonha
Published: March 2022

Silicon (Si) is absorbed and accumulated by some plant species; it has been shown to improve plant growth and performance. The beneficial role of Si in plants is based on the fundamental assumptions, and the biological function of Si is still being researched due to its complex nature, distinctiveness, and interaction. The present study included two distinct experiment sets: a screening test and an advanced test. In the initial examination, we used 21 soybean (Glycine max L.) cultivars. Following the evaluation, we chose four cultivars to investigate further. In particular, the positive response cultivars, Taeseon and Geomjeongsaeol, showed a 14% increase in net photosynthesis (PN), and a 19–26% increase in transpiration in Si-treated plants when compared to the control plants. Si-treated Taeseon, Geomjeongsaeol, and Somyongkong, Mallikong cultivars showed significant differences in root morphological traits (RMTs) and root system architecture (RSA) when compared to the control plants. Taeseon and Geomjeongsaeol showed a 26 and 46% increase in total root length (TRL) after Si application, respectively, compared to the control, whereas Mallikong and Somyongkong showed 26 and 20% decrease in TRL after Si treatment, respectively, compared to the control. The Si application enhanced the overall RMTs and RSA traits in Taeseon and Geomjeongsaeol; however, the other two cultivars, Somyongkong and Mallikong, showed a decrease in such RMTs and RATs. Furthermore, to understand the underlying molecular mechanism and the response of various cultivars, we measured the Si content and analyzed the gene expression of genes involved in auxin transport and root formation and development. We showed that the Si content significantly increased in the Si-treated Somyongkong (28%) and Taeseon (30%) compared to the control cultivars. Overall, our results suggested that Si affects root development as well as the genes involved in the auxin synthesis, transport pathway, and modulates root growth leading to cultivar-dependent variation in soybeans.
Rapid On-Site Detection of the Bursaphelenchus xylophilus Using Recombinase Polymerase Amplification Combined With Lateral Flow Dipstick That Eliminates Interference From Primer-Dependent Artifacts
Authors: Zhou Qinzheng , Liu Ya , Wang Zheng , Wang Huimin , Zhang Xingyao , Lu Quan
Published: March 2022

The pine wood nematode (PWN), Bursaphelenchus xylophilus, is one of the most lethal nematode species, which causes pine wilt disease (PWD), a devastating forest disease. To date, no effective methods have been developed to control the disease; hence, rapid precise detection of B. xylophilus is of great significance. Traditional molecular diagnostic methods are time-consuming and require sophisticated instruments or skilled operators, which are unavailable in resource-limited settings. A specific, sensitive, and field-applicable diagnostic method is urgently needed. In this study, we developed a diagnostic method using recombinase polymerase amplification combined with lateral flow dipstick (RPA-LFD) for the rapid on-site detection of B. xylophilus. The false-positive signals from primer-dependent artifacts were eliminated using a probe, and base substitutions were included in the primer and probe. The entire detection process for the RPA-LFD assay can be completed under 38°C within approximately 30 min, including 15 min for crude nematode genomic DNA (gDNA) extraction and master mix preparation, 15 min for the RPA-LFD assay. This assay displayed high specificity toward B. xylophilus and showed no cross-reactions with closely related species, including Bursaphelenchus mucronatus and Bursaphelenchus doui. The sensitivity of this assay had a detection limit as low as 1 pg of B. xylophilus purified genomic DNA. Furthermore, the application of the RPA-LFD assay in simulated spiked pinewood samples showed accurate detection results. The RPA-LFD assay in this study successfully detected B. xylophilus in less than 30 min, providing a novel alternative for the simple, sensitive, and specific detection of B. xylophilus and showed potential for B. xylophilus point-of-care testing (POCT) in resource-limited areas or in field.
Introgression of Trifolium ambiguum Into Allotetraploid White Clover (Trifolium repens) Using the Ancestral Parent Trifolium occidentale as a Bridging Species
Authors: Ullah Ihsan , Ansari Helal A. , Verry Isabelle M. , Hussain Syed Wajid , Ellison Nick W. , McManus Michael T. , Williams Warren M.
Published: March 2022

White clover (Trifolium repens) is an allotetraploid pasture legume widely used in moist temperate climates, but its vulnerability to drought, grazing pressure and pests has restricted its wider use. A related species, Caucasian clover (Trifolium ambiguum), is a potential source of resistances to drought, cold, grazing pressure and pests that could potentially be transferred to white clover by interspecific hybridization. Although direct hybridization has been achieved with difficulty, the hybrids have not been easy to backcross for introgression breeding and no interspecific chromosome recombination has been demonstrated. The present work shows that interspecific recombination can be achieved by using Trifolium occidentale, one of the ancestral parents of T. repens, as a bridging species and that large white clover breeding populations carrying recombinant chromosomes can be generated. A 4x hybrid between T. ambiguum and T. occidentale was crossed with T. repens and then backcrossed for two generations. Five backcross hybrid plants with phenotypes appearing to combine traits from the parent species were selected for FISH-GISH analyses. Recombinant chromosome segments from T. ambiguum were found in all five plants, suggesting that recombination frequencies were significant and sufficient for introgression breeding. Despite early chromosome imbalances, the backcross populations were fertile and produced large numbers of seeds. These hybrids represent a major new resource for the breeding of novel resilient forms of white clover.
An Event-Related Potential Study on Differences Between Higher and Lower Easy of Learning Judgments: Evidence for the Ease-of-Processing Hypothesis
Authors: Cong Peiyao , Jia Ning
Published: March 2022

Easy of learning (EOL) judgments occur before active learning begins, and it is a prediction of how difficult it will be to learn new material in future learning. This study compared the amplitude of event-related potential (ERP) components and brain activation regions between high and low EOL judgments by adopting ERPs with a classical EOL judgment paradigm, aiming to confirm the ease-of-processing hypothesis. The results showed that (1) the magnitudes of EOL judgments are affected by encoding fluency cues, and the judgment magnitude increases with encoding fluency; (2) low EOL judgments are associated with higher N400 amplitude at the left superior frontal gyrus (SFG) and left middle frontal gyrus (MFG). High EOL judgments showed enlarged slow-wave (600–1,000 ms) potentials than low EOL judgments at the left medial temporal lobe (MTL), right ventromedial prefrontal cortex (VMPFC), and dorsolateral prefrontal cortex (DLPFC). Our results support the ease-of-processing hypothesis, particularly, by affirming that EOL judgments are affected by encoding fluency in two processing stages. N400 reflects the process of acquiring encoding fluency cues, while slow-wave indicates that individuals use encoding fluency cues for metacognitive monitoring.
Prevalence and Contributing Factors of Childhood Trauma, Anxiety, and Depression Among Adolescents From Two-Child Families in China
Authors: Tong Jie , Zhang Tingting , Chen Fazhan , Wang Qiang , Zhao Xudong , Hu Manji
Published: March 2022

The two-child policy has been implemented in China since 2016 and has attracted the attention of the world. Adolescents may face huge psychological challenges in the process of changing family structures and relationships. To date, no mental health survey of adolescents from two-child families has been conducted. We investigated the prevalence and risk factors for childhood trauma, anxiety, and depression in two-child families in a statistically representative sample of Chinese senior high school students from Shanghai. A total of 426 participants were randomly selected from 1,059 students of four senior high schools in different districts of Shanghai. The childhood trauma questionnaire-short form (CTQ-SF), self-rating anxiety scale (SAS) and self-rating depression scale (SDS) were used as the screening tools. We found that the overall prevalence of childhood trauma, anxiety, and depression among senior high school students in two-child families was 46.70% (95% CI, 39.93–53.47%), 22.17% (95% CI, 16.53–27.81%), and 35.85% (95% CI, 29.34–42.36%), respectively. The two-child families was an important factor associated childhood trauma, emotional neglect, and physical neglect (χ2 = 5.984, p = 0.014; χ2 = 4.071, p = 0.044; χ2 = 4.202, p = 0.040). Ranking in two-child families was a risk factor for childhood trauma (β = −0.135, p = 0.048). Parental preference was a significantly correlated with physical abuse, physical neglect, anxiety, and depression (β = −1.581 to 0.088, p < 0.05). Meanwhile, emotional abuse, physical abuse, emotional neglect, and physical neglect of participants in the two groups were positively correlated with anxiety and depression (r = 0.195–0.478, p < 0.05). There was a significant relationship between sexual abuse and anxiety symptoms in the one-child family group (r = 0.161, p < 0.05). The findings suggest that the overall prevalence of childhood trauma, anxiety and depression among adolescents from two-child families in China was high. The two-child families and family ranking are important factors associated childhood trauma, while parental preference is related to anxiety and depression. These results highlight an urgent need to be addressed by adolescents' mental health service providers and policy-makers.
A Factorial Randomized Controlled Trial of Implementation-Intention-Based Self-Affirmation Interventions: Findings on Depression, Anxiety, and Well-being in Adults With Psoriasis
Authors: Łakuta Patryk
Published: March 2022

This study builds on growing evidence on implementation-intention-based self-affirmation intervention effects on mental health. Using a factorial design, this pre-registered study aimed to further investigate whether (1) strengthening the element of specificity within body-related self-affirming implementation intention (BS-AII) intervention compared to general self-affirming implementation intention (S-AII) would provide greater improvements in mental health outcomes for adults with psoriasis, and (2) whether the addition of a booster component would result in enhancing effectiveness at follow-up. A total of 306 adults with psoriasis were assessed for eligibility and 222 (aged 18–71 years) were randomized and received S-AII, BS-AII, or MGI (mere goal intention—control condition). Within each group, participants were again randomized to booster (B) or no-booster condition in a 3 × 2 factorial design, resulting in six groups: S-AII; S-AII + B; BS-AII; BS-AII + B; MGI; and MGI + B. Data were collected over three-time points, at baseline, 2 weeks post-intervention, and at 1-month later. Three primary outcomes were defined as a reduction of anxiety and depressive symptoms and enhancement of well-being. In terms of secondary outcomes, positive other- and self-directed feelings and also an emotional attitude toward the body were evaluated. To fully estimate intervention effects through intention-to-treat analysis, linear mixed models were used. A significant effect of time was observed, but no evidence of time-by-group interactions and no three-way interactions were detected. Exploratory analyses revealed two significant moderating effects of age and self-esteem, pointing to boundary conditions of the interventions. These findings offer to gain deeper insights on null (or negative) effects also reported in past works and highlight that self-affirmation interventions should be more thoroughly investigated and optimized before they can be broadly implemented in real-life contexts, especially to prevent backfiring and negative-enhancing effects.
The Moderating Effects of Social Media Activities on the Relationship Between Effort-Reward Imbalance and Health and Wellbeing: A Case Study of the Oil and Gas Industry in Malaysia
Authors: Kanwal Noreen , Isha Ahmad Shahrul Nizam
Published: March 2022

Background

Social media activities affect every aspect of human life, be it personal, social or professional. Previous studies have confirmed the role of social media in affecting health in terms of releasing stress and providing social support. Increased occupational health disorders and increased time spent on social media activities motivate us to investigate this phenomenon in the context of occupational health. Therefore, the objective of this study is to measure the effects of social media activities related to personal and social life as well as work-life on health and wellbeing of office employees, on their job efforts and job rewards, and in moderating the effect of effort-reward imbalance on health and wellbeing.

Methods

Initially, to develop constructs related to social media activities, web-based structured interviews were conducted with five office employees working in the oil and gas industry for the last 5 years. Then, using an online questionnaire survey, data was collected from 424 office employees working in the oil and gas industry in Malaysia. Using statistical software for social science (SPSS) and Smart PLS, exploratory factor analysis and confirmatory factor analysis were conducted to identify reliability and validity (discriminant validity, convergent validity and composite validity) of the constructs. Following this, path analysis was conducted and the moderating effects were identified.

Results

Social media activities related to work-life decrease health and wellbeing by 11% and weaken the negative effect of effort-reward-imbalance on health and wellbeing by 17.6% at a 1% level of significance. The results of social media activities related to personal and social life strengthen the negative effect of effort-reward imbalance on health and wellbeing by 12% and negatively affects health and wellbeing and job rewards by 13, 55%, respectively. The direct effect of effort-reward imbalance and job efforts is significantly negative on health and wellbeing by 59 and 10%, respectively.

Conclusion

It is concluded that social media activities of the office employees significantly moderate the effect of effort-reward imbalance on health and wellbeing and intervene in job rewards in the organizations. Hence, the effect of social media activities reduces the health and wellbeing of office employees.
A Governance Framework for Implementation of Scientific and Engineering Innovation in Buried Infrastructure Systems
Authors: Shrimpton Elisabeth A. , Hunt Dexter V. L. , Rogers Christopher D. F.
Published: March 2022

This article draws on experience within a pervasive sensing research project, the Pipebots project. The aim of the project is to design miniature robots to gather physical condition and environmental data on buried pipe networks, using potable water distribution and wastewater pipe systems as the initial target applications. One of the challenges of the project is to anticipate and address the potential governance issues triggered by the project. Due to the lack of a suitable tool with sufficient breadth to guide thinking, the existing literature has been drawn upon to form the basis of a governance framework for use in infrastructure projects. Whilst the original intention was to be alert to and interrogate the forms of governance that may impact on new infrastructure interventions, what is emerging is a tool that would support the strategy for implementation, improve the design (a no-regrets design policy) and help build the business case for the transformational change the project envisages.
Doppler Wind Lidar From UV to NIR: A Review With Case Study Examples
Authors: Shangguan Mingjia , Qiu Jiawei , Yuan Jinlong , Shu Zhifeng , Zhou Lingfeng , Xia Haiyun
Published: March 2022

Doppler wind lidar (DWL) uses the optical Doppler effect to measure atmospheric wind speed with high spatial-temporal resolution and long detection range and has been widely applied in scientific research and engineering applications. With the development of related technology, especially laser and detector technology, the performance of the DWL has significantly improved for the past few decades. DWL utilizes different principles and different tracers to sense the wind speed from the ground to the mesosphere, which leads to the difference in choosing the laser working wavelength. This article will review the working wavelength consideration of DWL, and typical DWLs will present from ultraviolet to near-infrared, after which three typical applications will be shown.
The Economics of Agribusiness in Developing Countries: Areas of Opportunities for a New Development Paradigm in the Soybean Supply Chain in Brazil
Authors: Medina Gabriel da Silva
Published: March 2022

By understanding the economics of agribusiness, an important economic sector for developing countries, this article explores possibilities for a new development paradigm based on areas of opportunities created for local entrepreneurs. Based on a detailed study of the soybean market chain in Brazil, this paper illustrates that the current neoliberal economic approach has resulted in a business which is dependent on foreign multinationals. While foreign companies hold 60% of the soybean market share, Brazilian groups hold only 40% of the entire business, with the domestic market share concentrated in land (13.3%) and labor (14.3%). But the expansion of foreign investments in agribusiness in the country offers opportunities occupied by Brazilian companies, characterizing a situation of associated dependent development. Currently, 12.4% of the share held by Brazilian companies belongs to capital and technology intensive segments such as seed production (2.4%), fertilizers (4.8%), agrochemicals (0.6%), machinery (0.3%), and agro-industry trade (4.3%). The increase in the participation of Brazilian groups in agribusiness requires agricultural policies that can be inspired by a new development paradigm. Opportunities created by foreign investments can be used by domestic groups to increase their share in agro-industrial sectors. Lessons from the Brazilian case can help other developing countries to explore areas of opportunities for domestic investments in dynamic economic sectors such as agribusiness.
RING-Finger Protein 6 promotes Drug Resistance in Retinoblastoma via JAK2/STAT3 Signaling Pathway
Authors: Chai Yong , Jiao Shoufeng , Peng Xin , Gan Qiang , Chen Leifeng , Hu Xiaolu , Hao Liang , Zhang Shouhua , Tao Qiang
Published: March 2022

Chemotherapy is the first-line treatment for human retinoblastoma (RB), but the occurrence of drug resistance greatly limited its efficacy in practice. RING-finger protein 6 (RNF6) is an E3 ubiquitin ligase that is aberrantly upregulated in a range of cancers and plays important roles in cancer progression. However, the role of RNF6 in RB is largely unknown. In this study, we investigated the role of RNF6 in RB drug resistance. Two carboplatin-resistant RB cells, Y-79/CR and SO-Rb50/CR, were generated based on Y-79 and SO-Rb50 cells. RT-PCR and western blot analyses showed that RNF6 expression on both mRNA and protein levels was significantly increased in Y-79/CR and SO-Rb50/CR cells comparing to their parental cells. Knockdown of RNF6 using siRNA in Y-79/CR and SO-Rb50/CR cells resulted in cells sensitive to carboplatin on a RNF6 siRNA dose dependent manner. Similarly, RNF6 overexpression in parental Y-79 and SO-Rb50 cells could help cells gain resistance to carboplatin on a RNF6 expression dependent manner. Signaling pathway analyses revealed that JAK2/STAT3 pathway was involved in the RNF6-induced carboplatin resistance in RB cells. We further revealed that RNF6 expression in both Y-79 and SO-Rb50 cells could render cells resistant to multiple anti-cancer drugs including carboplatin, vincristine and etoposide, an implication of RNF6 as a biomarker for RB drug resistance. Taken together, our study has revealed that RNF6 is upregulated in drug-resistant RB cells and RNF6 promotes drug resistance through JAK2/STAT3 signaling pathway. The importance of RNF6 in RB cells drug resistance may represent this protein as a potential biomarker and treatment target for drug resistance in RB.
THE IINFLUENCE OF N-CARBAMYLGLUTAMATE ON THE UTILIZATION OF FREE AMMONIA IN THE BODY AND MILK PRODUCTIVITY OF COWS
Authors: Кузнецов А.С. , ОСТРЕНКО К.С. , КУЗНЕЦОВА Т.С.
Published: March 2022

Кормовая добавка «Алтавим NCG» (добавка c NCG), содержащая N-карбомилглутамат (NCG), повышает эффективность утилизации аммиака и использование азота рациона, что оказывает влияние на увеличение показателей молочной продуктивности. Подтверждено получение положительного результата от применения добавки с NCG в рационе, который содержит сорбенты аммиака и кормовые добавки для повышения транзита белка через рубец. Добавление 20 г на 1 голову в сутки испытуемой добавки в рацион высокопродуктивных коров в условиях сельхозпредприятия уменьшало содержание аммиака в крови на 44,78%, повышало эффективность использования азота корма на 2,1% и увеличивало молочную продуктивность коров на 0,9 кг в сутки по сравнению с контролем. Отмечено, что в опытной группе продуктивность выросла со 180-го по 210-й день лактации и оставалась выше в период наблюдения последействия, чем в начале опыта. Качественные показатели состава молока не изменились. Установлено наличие положительной динамики в сторону снижения количества соматических клеток в опытной группе.

The feed additive "Altavim NCG" containing N-carbomylglutamate (NCG) helps to increase the efficiency of ammonia utilization and the use of nitrogen in the diet, which favorably affects the increase in milk productivity. It was confirmed that a positive result was obtained from the use of an additive with NCG in the diet containing ammonia sorbents and feed additives to increase the transit of protein through the scar. The addition of 20 g per 1 head per day of the tested additive to the diet of highly productive cows in the  conditions of an agricultural enterprise reduced the ammonia content in the blood by 44.78%, increased the efficiency of feed nitrogen use by 2.1% and increased the dairy productivity of cows by 0.9 kg per day compared with the control. It was noted that in the experimental group, productivity increased from the 180th to the 210th day of lactation and remained higher during the follow-up period than at the beginning of the experiment. The qualitative indicators of the milk composition have not changed. The presence of positive dynamics towards a decrease in the number of somatic cells in the experimental group was established.
Tinjauan Yuridis Pengadaan Tanah Rumah Sakit Sumber Waras Tahun 2014 untuk Kepentingan Umum oleh Pemerintah Daerah Provinsi DKI Jakarta
Authors: Harun Harun , Fahruddin Muhammad
Published: March 2022

ABSTRACT

 

This research discusses the juridical study of land acquisition for the public interest in DKI Jakarta Province. This research uses a normative juridical method with an approach to reviewing laws and regulations and the President's Rule with the aim of exploring the rules governing the implementation of land acquisition for development in the public interest, which can be seen from legal sources, legal subjects, legal objects, characteristics and forms. sanctions, as well as the formulation of the criminal and criminal sanctions itself. The results of this study are in the Province of DKI Jakarta, Indonesia.

 

Keywords: Juridical Review, Public Interest, Presidential Regulation No.71 of 2012

 

 

 

ABSTRAK

 

Penelitian ini membahas tentang kajian Yuridis pengadaan Lahan untuk kepentingan umum di Propinsi DKI Jakarta.  Penelitian ini menggunakan metode yuridis normatif dengan pendekatan kajian peraturan perundang-undangan dan Peratutan Presiden dengan  Tujuuan untuk mendalami tentang aturan yang mengatur tentang Penyelenggaraan Pengadaan tanah bagi pembangunan untuk kepentingan umum, yang dapat dilihat dari sumber hukum, subjek hukum, objek hukum, sifat dan bentuk sanski, serta rumusan pidana dan sanksi pidana itu sendiri. Hasil penelitian ini adalah di Propinsi DKI Jakarta Indonesia.

 

 

Kata kunci :Tinjauan Yuridis, Kepentingan Umum, Peraturan Presiden No.71 tahun 2012
PENCEGAHAN MODUS PELANGGARAN KODE ETIK PENYELENGGARA PEMILU DALAM PENETAPAN CALON KEPALA DAERAH
Authors: Arifudin Arifudin , . Nurwidyanto
Published: March 2022

Penetapan pasangan calon dalam pemilihan kepala daerah merupakan tahap penting dalam proses pemilihan kepala daerah yang demokratis. Faktanya dalam proses penetapan pasangan calon dalam Pilkada Kabupaten Garut Tahun 2018 menimbulkan pelanggaran kode etik berupa pemberian uang dan/atau barang. Oleh karena itu tulisan ini merumuskan pertanyaan penelitiannya sebagai berikut: faktor-faktor apa yang menyebabkan munculnya modus pelanggaran etika penyelenggara pemilu dalam penetapan calon kepala daerah?; dan bagaimana pencegahan modus pelanggaran etika penyelenggara pemilu dalam penetapan calon kepala daerah?. Temuan dalam tulisan ini dapat disimpulkan bahwa modus pelanggaran kode etik dalam penetapan pasangan calon kepala daerah tidak hanya ditimbulkan oleh perbuatan penyelenggara pemilu namun juga disebabkan oleh peserta pemilu,yakni bakal pasangan calon maupun tim suksesnya yang mendorong penyelenggara pemilu melakukan pelanggaran kode etik. Oleh karena itu, diperlukan instrument pendidikan etika bagi bakal calon kepala daerah, pra verifikasi bakal pasangan calon kepala daerah, serta sanksi bagi penyelenggara pemilu maupun bakal calon kepala daerah belum dirumuskan dalam suatu perundang-undangan.
alimento como remédio natural”
Authors: Palandri Sigolo Renata
Published: March 2022

O objetivo deste texto é propor a compreensão de alguns conceitos relacionados à alimentação natural idealizada na década de 1970 no Brasil. Para isso, foram analisadas duas obras: Sugar Blues e “Do Jardim do Éden à Era de Aquarius”, ambas publicadas originalmente nos Estados Unidos, traduzidas e lançadas no Brasil na década de 1970 pela Editora Ground, que se propunha fornecer ao grande público informações sobre como viver um “estilo de vida alternativo”. A alimentação natural esteve relacionada à ascensão das medicinas alternativas e compunha a busca por um estilo de vida que partilhava de conceitos da Contracultura e do New Age e que via na natureza a fonte da saúde desejada.
Discursos médico-pedagógicos e a luta contra a sífilis na cidade da Parahyba do Norte/João Pessoa (1921-1938)
Authors: Nóbrega Araújo Rafael
Published: March 2022

O artigo analisa o combate à sífilis na cidade da Parahyba do Norte/João Pessoa entre 1921 e 1938. A partir da inauguração do Dispensário “Eduardo Rabello”, foram estabelecidas as primeiras políticas públicas na profilaxia e tratamento da doença, visando transformar higienicamente os hábitos da população. Em 1938, o Serviço de Profilaxia da Sífilis e Doenças Venéreas inaugurava o Dispensário Noturno Antivenéreo, que passou a oferecer profilaxia e tratamento gratuitos à noite para os trabalhadores da cidade. A documentação produzida na imprensa da época revela os enfrentamentos por parte de médicos e do poder público contra a sífilis, destacando a propaganda sanitária como prática educativa.
Beethoven na filosofia da arte hegeliana
Authors: Rodrigues Raposo Reginaldo
Published: March 2022

O artigo tece considerações sobre a relação filosófico-musical de Hegel com as transformações promovidas pela contribuição de Beethoven, através dos documentos históricos que compõem o que se toma pela Estética hegeliana. A partir das observações feitas pelo musicólogo alemão do século XX, Carl Dahlhaus, acerca desta mesma articulação, buscamos identificar e analisar a leitura que enxerga na crítica hegeliana à música de seu tempo sutilezas que apontam para além da percepção de uma mera “indisposição” de tendência classicista por parte do filósofo. Demonstramos ainda como essas observações conduzem a sentidos que, por sua vez, reafirmam o lugar específico da música enquanto arte particular e a característica de seu movimento no todo da Estética e da filosofia hegeliana.
Beethoven para Adorno: ideal envelhecido ou "envelhecimento" ideal
Authors: Batalhão Bruna
Published: March 2022

Em sua crítica, na década de 1950, à música serialista, o filósofo Theodor Adorno evoca Beethoven como o ideal de uma música dinâmica de essência dialética. Quando apontada a limitação da estética adorniana para a compreensão da arte que lhe era contemporânea, é justamente o ideal beethoveniano vinculado à tradição musical austro-germânica que se tem em vista, como se esse houvesse envelhecido. A análise de Adorno da transformação desse ideal no Beethoven tardio poderia apontar para formas de construção de qualidade não dinâmica sem, contudo, serem tomadas simplesmente como regressivas, em uma concepção de estilo tardio não envelhecido.
Esquecimento e Serenidade em Heidegger
Authors: Ferreira Alexandre
Published: March 2022

No presente artigo discuto o esquecimento do ser no Heidegger tardio e sua relação com as noções de acontecimento-apropriativo (Ereignis) e serenidade (Gelassenheit). Para tanto, compararei alguns escritos tardios de Heidegger, sobretudo as preleções “Tempo e Ser” e “Serenidade”, com o curso sobre “Fenomenologia da vida religiosa”, este último ministrado em 1920. Parece-me que no curso de juventude há uma estrutura de pensamento que se repete no Heidegger tardio – sobretudo no que concerne ao conceito de indicação formal e à compreensão da parousia em Paulo – e que pode lançar uma luz sobre a relação entre esquecimento, acontecimento-apropriativo e serenidade. Terminarei o artigo sugerindo a possibilidade de pensar uma ética da serenidade em Heidegger.
Optimalisasi Jalur Evakuasi Tsunami di Kelurahan Lolong Belanti
Authors: Yasman Jorandy
Published: March 2022

Padang merupakan ibu kota provinsi Sumatera Barat yang memiliki tata ruang yang didominasi pada kawasan pesisir. Kelurahan Lolong Belanti merupakan salah satu daerah dengan tingkat resiko  terhadap bencana tsunami. Oleh karena itu, Jln. Beringin Raya perlu melakukan pengoptimalisasikan jalur evakuasi  bencana tsunami dan perlu memiliki sistem jalur evakuasi dan ruang untuk evakuasi kebencanaan sebagai bentuk kesiapsiagaan bencana. Penelitian ini bertujuan memberikan gambaran kesiapan masyarakat untuk penyelamatan diri ketika terjadi bencana dan untuk mengetahui persepsi masyarakat tentang jalur evakuasi di Kelurahan Lolong Belanti. Penelitian ini menggunakan pendekatan kualitatif deskriptif, dengan menggunakan pengumpulan data primer berupa wawancara dengan informan yang mengetahui tentang kebencanaan dan pengumpulan data sekunder berupa dokumen-dokumen yang terkait dengan penanggulangan bencana di Kota Padang. Penelitian menghasilkan bahwa kesiapsiagaan dan informasi rambu petunjuk perlu diperbanyak atau ditingkatkan lagi mengenai tentang jalur evakuasi dan apa yang harus dilakukan ketika terjadi bencana masyarakat lolong belanti cukup paham dan mengerti apa yang harus dilakukan
KARAKTER MORFOLOGI DAN TIPE STELE TUMBUHAN PAKU TERESTERIAL DI HUTAN LINDUNG JUWATA KERIKIL KOTA TARAKAN SEBAGAI SUMBER BELAJAR BIOLOGI
Authors: Siska Siska , Marwiyah Marwiyah , Santi Santi , Hasdar Hasdar , Aditiyanto Megita
Published: March 2022

The goal of this resarch is to identify morphological characters and stele types of terestrial ferns in RPH Barat (Juata Kerikil) Forest. The result of research was analyzed the suitability to biology learning. This research used qualitative approach, and the sampling technique that was used was adaptive sampling. The result showed that the terestrial ferns consist of 12 species. Based on morphometri of frond, Overall, the ferns had many variety in the size. The largest one was Cyathea podophylla, and the smallest one is Trichomanes maximum. Next, Depend on stele type, majority of ferns have Dictyostele, nine of them have this stele type. In addition, the result related to Plant Taxonomy course and Plant Morphology course. Furthermore, the research related in Senior High School Curriculum (Curriculum 2013), especially in Plantae content. Keywords : Morphology, Stele, Terestrial Ferns
IMPLEMENTASI LESSON STUDY DI KELAS IX D PADA MATERI KELISTRIKAN DAN TEKNOLOGI LISTRIK DI LINGKUNGAN UNTUK MENINGKATKAN KEMAMPUAN MINAT DAN HASIL BELAJAR KOGNITIF SISWA SMP NEGERI 2 TARAKAN
Authors: Kunarti Dewi
Published: March 2022

Abstract: Lesson Study is an effort to improve the learning process and outcomes which is carried out collaboratively and continuously by a group of teachers. One aspect of improving the learning process using the Lesson Study-based CAR approach is the aspect of interest in learning. With the increasing interest in learning possessed by students, it will also have an effect on improving cognitive learning outcomes, especially in this research in class IX D on Electricity and Electrical Technology in the Environment at SMP Negeri 2 Tarakan. The approach used in this research is to follow the research flow Plan, Do, See. Conducted in 3 stages for 4 cycles. The plot, which begins with the planning stage (plan), at this stage, activities to analyze the needs and problems faced in learning are carried out. Furthermore, the implementation stage (do) is carried out, in the second stage, there are two main activities: 1) learning activities carried out by one of the model teachers, and 2) observation or observation activities carried out by other members or the Lesson Study community. And in the last stage, the reflection (see) is carried out after the teacher has learned in the classroom. Based on the research results obtained posttest. In the cognitive learning outcomes the average value in cycle I was 71.68, cycle II 76.06, cycle III 90.14, and cycle IV was 91.09. Furthermore, for the results of interest in learning, the average value in cycle I was 61.61, cycle II 61.94, cycle III 60.05, and cycle IV was 61.75. From the results of these studies, it can be concluded that the implementation of lesson study can increase interest and cognitive learning outcomes of class IX D students of SMP Negeri 2 Tarakan on electricity and electrical technology. Keywords:  lesson study, interest, cognitive