bluuebunny/crossref_metadata_2025 huggingface dataset:
Solicitação de exames de apoio diagnóstico por médicos na Atenção Primária à Saúde
Authors: Figueiredo Maria Fernanda Santos , Borém Luciana Mendes Araújo , Vieira Marta Raquel Mendes , Leite Maisa Tavares de Souza , Rodrigues Neto João Felício
Published: November 2017

RESUMO Objetivou-se compreender a solicitação de exames por médicos na Atenção Primária à Saúde. Trata-se de estudo qualitativo, com médicos de família de Montes Claros (MG). Os dados foram obtidos por entrevista não estruturada e examinados via análise do discurso. A solicitação de exames é influenciada pela formação profissional, pelas características da Estratégia Saúde da Família - primeiro contato para as questões de saúde; realização do cuidado integral, continuado e coordenado pela equipe -, pela possibilidade de gerir o tempo de atendimento, pelo trabalho multiprofissional e pelas dificuldades enfrentadas - demanda dos pacientes por exames e pressão dos gestores por menos solicitações.
Vigilância em Saúde do Trabalhador: um estudo à luz da Portaria nº 3.120/98
Authors: Vianna Lorena Cristina Ramos , Ferreira Aldo Pacheco , Vasconcellos Luiz Carlos Fadel de , Bonfatti Renato José , Oliveira Maria Helena Barros de
Published: November 2017

RESUMO A saúde do trabalhador é um campo de práticas e conhecimentos de enfoque teórico-metodológico da saúde pública, cujo objeto é o processo saúde-doença do homem em sua relação com o trabalho. Analisaram-se as principais ações na Vigilância em Saúde do Trabalhador e na prevenção de acidentes de trabalho. O referencial teórico baseou-se na corrente filosófica do materialismo histórico e dialético da saúde do trabalhador. Nas entrevistas, obtiveram-se reflexões e depoimentos de profissionais do Centro de Referência em Saúde do Trabalhador (Cerest/RJ) para análise de conteúdo. Os resultados revelam importantes lacunas que afetam as ações atuais nessa área, quanto à distância entre conhecimento teórico, sua apreensão e sua aplicação.
Surfando no controle: os lugares que os agentes comunitários ocupam na produção de saúde mental
Authors: Borges Silier Andrade Cardoso , Duarte Marco José de Oliveira
Published: November 2017

RESUMO Este artigo aborda os lugares que os agentes comunitários ocupam na produção de saúde mental, através de conceitos como sociedade de controle, sujeito da experiência e clínica peripatética. Propõe-se uma leitura de orientação cartográfica sobre a interface entre saúde mental e Agentes Comunitários de Saúde. Retomam-se os percursos da Reforma Psiquiátrica com o Programa de Agentes Comunitários de Saúde e a Estratégia Saúde da Família. Finaliza com a discussão sobre os lugares paradoxais ocupados entre o poder sanitário e o universo sociocultural do território nas práticas dos agentes, de modo a problematizar a observação de Lancetti, de que tais profissionais surfam no controle.
Production and antioxidative metabolism in bell pepper grown with saline water in hydroponic system
Authors: Lima Nadielan da S. , Morais Marciana B. de , Silva Ênio F. de F. e , Camara Terezinha R. , Willadino Lilia
Published: November 2017

ABSTRACT This study aimed to evaluate the effect of salt stress on production and antioxidative defense metabolism of two bell pepper cultivars (Capsicum annuum L.) grown hydroponically. The experimental design was in randomized blocks, with treatments arranged in a 5 x 2 factorial scheme with five replicates. The treatments consisted of five salinity levels of the nutrient solution (2.0, 3.5, 4.5, 5.5 and 6.5 dS m-1) with two bell pepper cultivars, ‘Bruno’ and ‘Rúbia’. Biomass and yield were reduced with increasing salinity. The contents of chlorophyll a, b and total decreased with increasing salinity. There was an increase in proline content and activity of superoxide dismutase (SOD), catalase (CAT) and ascorbate peroxidase (APX), showing the activation of the antioxidant defense mechanism. The higher yield in the cv. ‘Rúbia’, as well as the greater activity of the APX and the lower levels of chlorophyll content, reflect the best acclimatization of this cultivar to saline stress. The estimated yield of the cv. ‘Rúbia’, 39.9 t ha-1 when grown with ECs of up to 3.5 dS m-1, indicates the feasibility of its commercial cultivation in hydroponic conditions.
Mathematical modeling of the foam-mat drying curves of guava pulp
Authors: Maciel Roberta M. G. , Afonso Marcos R. A. , Costa José M. C. da , Severo Leandro S. , Lima Natália D. de
Published: November 2017

ABSTRACT In foam-mat drying, the liquid food is foamed by the addition of a foaming agent, for example, albumin. The aim of this study was to evaluate the adjustment of mathematical models to foam mat drying curves of guava pulp. The fits were evaluated using samples with 4 and 8% albumin (m m-1) and drying temperatures of 75, 80 and 85 °C. The samples were placed on aluminum trays. Drying was carried out in a tray dryer. The Lewis, Page, Midilli and Logarithmic models were fitted to the experimental data and evaluated based on the coefficient of determination (R2), root-mean-square error (RMSE) and chi-square test. All models fitted well to experimental data and Midilli was the best. Albumin concentration and temperature influenced the drying rate; the lowest drying times occurred for the highest albumin concentration and highest drying temperature.
Soybean development as a function of traffic of tractor with radial tires
Authors: Espessato Renan R. , Leite Fabrício , Guerreiro Julio C. , Quiqui Erci M. Del , Azevedo Ana P. de , Aleixo Edward V.
Published: November 2017

ABSTRACT This study aimed to evaluate the development of soybean as a function of traffic levels of an agricultural tractor equipped with radial tires in two collection areas. The experiment was conducted in an area located at the State University of Maringá, Campus of Umuarama-PR, Brazil, in a soil classified as Red Oxisol with sandy texture. The experiment was set in a 5 x 2 factorial arrangement, with five levels of traffic on the same track (T1 = 1, T2 = 6, T3 = 11, T4 = 16 and T5 = 21 tractor passes), two collection areas (A1 = on the track and A2 = off the track) and four replicates. Soil physical parameters and characteristics of the soybean plants were evaluated. Soybean yield on the track did not show significant difference up to 6 passes. It was concluded that the traffic levels and soil resistance to penetration interfere with soybean yield for both collection areas.
Toxic effect of commercial formulations of neem oil, Azadirachta indica A. Juss., in pupae and adults of the sugarcane borer, Diatraea saccharalis F. (Lepidoptera: Crambidae)
Authors: Schneider Larissa Carla Lauer , Silva Camila Vieira da , Conte Hélio
Published: November 2017

ABSTRACT: To evaluate the toxic effect of commercial formulations of neem oil, Azadirachta indica A. Juss, pre-pupae (PP), young pupae (YP) and old pupae (OP) of Diatraea saccharalis F. (Lepidoptera: Crambidae) were sprayed with the diluted extract in distilled water at concentrations of 0.0, 0.3, 0.5, 1.0 and 2.0%. The neem extract caused concentration-dependent effects on mortality of pupae, and the pupae that failed to emerge in adults had multiple abnormalities. The longevity of pupae that emerged in adults (YP and OP group) did not differ from the control group. The abnormalities found in adults were related to mortality in all treatments, except at the concentration of 1.0%. Fertility was assessed according to the oviposition of adult females from the YP group that showed no abnormalities, through the evaluation of the number of deposited eggs and the rate of undeveloped eggs. The results showed a reduction in the number of eggs laid and an increase in the percentage of undeveloped eggs. These results show that neem oil has a high potential to control the toughest stage of the sugarcane borer and also reduces the further development. Therefore, commercial formulations of neem oil have a toxic effect on pupae and adults of D. saccharalis.
Vulnerabilidade social em famílias que convivem com comportamento aditivo por tempo prolongado
Authors: Reis Lúcia Margarete dos , Oliveira Magda Lúcia Félix de
Published: November 2017

Resumo Objetivo Analisar a vulnerabilidade social de famílias que convivem por tempo prolongado com o comportamento aditivo de um de seus membros. Métodos Estudo transversal, com familiares de 29 usuários de drogas, internados com trauma físico associado à intoxicação por drogas de abuso entre abril a setembro de 2014. Utilizou-se o Índice de Vulnerabilidade das Famílias Paranaenses, composto pelas dimensões: adequação do domicílio; perfil e composição familiar; acesso ao trabalho e renda e escolaridade. Os dados foram analisados por medidas de tendência. Resultados Os usuários tinham média de idade de 40,1 anos e comportamento aditivo médio de 20,8 anos. Apenas três famílias não estavam em vulnerabilidade social, e a maior vulnerabilidade foi em relação ao acesso ao trabalho e renda (79,3%) e escolaridade (82,6%), com relação proporcional entre essas dimensões. Conclusão Encontrou-se agravamento da vulnerabilidade em indicadores de longo prazo, proporcional aos anos de enfrentamento às drogas.
Classificação e agrupamento das cidades brasileiras em graus-dia de aquecimento e resfriamento: 1960 a 2013
Authors: Stensjö Iraci Pereira , Ferreira Camila Carvalho , Loura Rejane Magiag
Published: November 2017

Resumo Graus-dia são usualmente utilizados no mundo para estimar o consumo de energia devido ao aquecimento e/ou resfriamento em edificações. Contudo, no Brasil, não há norma técnica que estabeleça um método de cálculo e/ou um zoneamento de graus-dia. Este trabalho apresenta uma proposta de cálculo do número de graus-dia aplicável em todo o país e um zoneamento nacional decorrente dessa classificação. A base de dados é composta pelas Normais Climatológicas e médias mensais do Banco de Dados Meteorológicos para Ensino e Pesquisa do INMET. Esses dados juntos permitem avaliar a evolução da condição climática das cidades. Os graus-dia de aquecimento (GDA) e resfriamento (GDR) foram calculados e as temperaturas de base foram definidas com base em um modelo adaptativo. Para a realização do agrupamento das cidades por GDA e GDR, foi utilizado o procedimento estatístico de cluster e, em seguida, a significância estatística dos agrupamentos gerados foi verificada através do Teste F. Como resultados, obteve-se a classificação das 317 cidades por número de GDA e GDR e o zoneamento proposto mostrou-se significante. Por fim, foram produzidos mapas do zoneamento das cidades brasileiras por demanda de aquecimento ou resfriamento.
Modelagem dos padrões da expansão urbana da Região Metropolitana de São Paulo baseada em Autômatos Celulares
Authors: Massabki José Augusto Rodrigues , Peixoto Anna Silvia Palcheco , Kaiser Ilza Machado , Manzato Gustavo Garcia
Published: November 2017

Resumo O objetivo deste trabalho foi modelar os padrões da expansão urbana da Região Metropolitana de São Paulo (RMSP) por meio da modelagem espacial, baseando-se em autômatos celulares (CA, do inglês: Cellular Automata). Para tanto foram utilizados dados do perímetro urbano referentes aos períodos de 1881, 1905, 1929, 1949, 1974 e 2005 para a construção de quatro modelos de expansão urbana. Esses modelos levam em consideração a combinação de variáveis as quais representam o estado inicial da célula (urbana ou não urbana), o número de células vizinhas classificadas como urbanas e o número de células vizinhas classificadas como não urbanas. Um modelo em particular, cuja configuração considera a combinação do estado inicial da célula com o número de células vizinhas classificadas como urbanas, apresentou o melhor desempenho (isto é, 94% de acertos). Na sequência, uma previsão de ocupação do território para 2030 foi avaliada por esse modelo, destacando-se tanto padrões de expansão urbana orientados por infraestruturas, como processos de ocupação urbana em áreas impróprias. Em síntese, esse estudo demonstrou que a metodologia empregada pode servir como ferramenta nos processos de planejamento urbano.
Cephalometric evaluation of adult anterior open bite non-extraction treatment with Invisalign
Authors: Moshiri Shuka , Araújo Eustáquio A. , McCray Julie F. , Thiesen Guilherme , Kim Ki Beom
Published: November 2017

ABSTRACT Objective: The purpose of this study was to evaluate, by means of cephalometric appraisal, the vertical effects of non-extraction treatment of adult anterior open bite with clear aligners (Invisalign system, Align Technology, Santa Clara, CA, USA). Methods: Lateral cephalograms of 30 adult patients with anterior open bite treated using Invisalign (22 females, 8 males; mean age at start of treatment: 28 years and 10 months; mean anterior open bite at start of treatment: 1.8 mm) were analyzed. Pre- and post-treatment cephalograms were traced to compare the following vertical measurements: SN to maxillary occlusal plane (SN-MxOP), SN to mandibular occlusal plane (SN-MnOP), mandibular plane to mandibular occlusal plane (MP-MnOP), SN to mandibular plane (SN-MP), SN to palatal plane (SN-PP), SN to gonion-gnathion plane (SN-GoGn), upper 1 tip to palatal plane (U1-PP), lower 1 tip to mandibular plane (L1-MP), mesiobuccal cusp of upper 6 to palatal plane (U6-PP), mesiobuccal cusp of lower 6 to mandibular plane (L6-MP), lower anterior facial height (LAFH), and overbite (OB). Paired t-tests and descriptive statistics were utilized to analyze the data and assess any significant changes resulting from treatment. Results: Statistically significant differences were found in overall treatment changes for SN-MxOP, SN-MnOP, MP-MnOP, SN-MP, SN-GoGn, L1-MP, L6-MP, LAFH, and OB. Conclusions: The Invisalign system is a viable therapeutic modality for non-extraction treatment of adult anterior mild open bites. Bite closure was mainly achieved by a combination of counterclockwise rotation of the mandibular plane, lower molar intrusion and lower incisor extrusion.
Quantification of intrusive/retraction force and moment generated during en-masse retraction of maxillary anterior teeth using mini-implants: A conceptual approach
Authors: Felicita A. Sumathi
Published: November 2017

ABSTRACT Objective: The aim of the present study was to clarify the biomechanics of en-masse retraction of the upper anterior teeth and attempt to quantify the different forces and moments generated using mini-implants and to calculate the amount of applied force optimal for en-masse intrusion and retraction using mini-implants. Methods: The optimum force required for en-masse intrusion and retraction can be calculated by using simple mathematical formulae. Depending on the position of the mini-implant and the relationship of the attachment to the center of resistance of the anterior segment, different clinical outcomes are encountered. Using certain mathematical formulae, accurate measurements of the magnitude of force and moment generated on the teeth can be calculated for each clinical outcome. Results: Optimum force for en-masse intrusion and retraction of maxillary anterior teeth is 212 grams per side. Force applied at an angle of 5o to 16o from the occlusal plane produce intrusive and retraction force components that are within the physiologic limit. Conclusion: Different clinical outcomes are encountered depending on the position of the mini-implant and the length of the attachment. It is possible to calculate the forces and moments generated for any given magnitude of applied force. The orthodontist can apply the basic biomechanical principles mentioned in this study to calculate the forces and moments for different hypothetical clinical scenarios.
Influence of the cranial base flexion on Class I, II and III malocclusions: a systematic review
Authors: Almeida Kélei Cristina Mathias de , Raveli Taísa Boamorte , Vieira Camila Ivini Viana , Santos-Pinto Ary dos , Raveli Dirceu Barnabé
Published: November 2017

ABSTRACT Objective: The aim of this study was to perform a systematic review on the morphological characteristics of the skull base (flexion, anterior length and posterior length) and the concomitant development of malocclusions, by comparing differences in dimorphism, ethnicity and age. Methods: The articles were selected by means of electronic search on BBO, MEDLINE and LILACS databases from 1966 to 2016. A qualitative evaluation of the methodologies used on the articles was also performed. Results: Although the literature on this topic is abundant, only 16 articles were selected for the present systematic review. The cranial base angle itself does not seem to play a significant role in the development of malocclusions. In fact, the cranial base angle is relatively stable at the ages of 5 to 15 years. Conclusions: A more obtuse angle at the skull base, in association or not with a greater anterior length of the cranial base, can contribute to the development of Class II division 1 malocclusions. On the other hand, a more acute angle at the skull base can contribute to a more anterior positioning of the mandible and to the development of Class III malocclusions.
Stability comparison of two different dentoalveolar expansion treatment protocols
Authors: Atik Ezgi , Taner Tülin
Published: November 2017

ABSTRACT Objective: The aim of this study was to compare the longitudinal stability of the conventional straight-wire system after the use of a quad-helix appliance with Damon self-ligating system in patients with Class I malocclusion. Methods: 27 adolescent patients were evaluated at three different periods: pre-treatment (T1), post-treatment (T2) and three years post-treatment (T3). Group 1 included 12 patients (with a mean age of 14.65 year) treated with Damon 3MX bracket system; and Group 2 included 15 patients (with a mean age of 14.8 year) who underwent orthodontic treatment with Roth prescribed brackets after expansion with Quad-Helix appliance. Relapse was evaluated with dental cast examination and cephalometric radiograph tracings. Statistical analysis was performed with IBM-SPSS for Windows software, version 21 (SPSS Inc., Chicago, IL). A p-value smaller than 0.05 was considered statistically significant. Results: There were significant increases in all transverse dental and postero-anterior measurements (except for UL6-ML mm in Group 1) with active treatment. There was some significant relapse in the long-term in inter-canine width in both groups and in the inter-first premolar width in Group 2 (p< 0.05). Significant decrease in all frontal measurements from T2 to T3 was seen for both groups. Upper and lower incisors significantly proclined in T1-T2 (p<0.05), however no relapse was found for both groups. When two systems were compared, there was no significant difference for the long-term follow-up period. Conclusion: Conventional (quad-helix appliance with conventional brackets) and Damon systems were found similar with regard to the long-term incisor positions and transverse dimension changes of maxillary arch.
Optimization of the bending stiffness of beam-to-column and column-to-foundation connections in precast concrete structures
Authors: COSTA R. R. R. , LIMA M. C. V. , ALVA G. M. S. , MAGALHÃES E. S.
Published: November 2017

Abstract This work involved the structural optimization of precast concrete rigid frames with semi-rigid beam-to-column connections. To this end, several frames were simulated numerically using the Finite Element Method. Beams and columns were modeled using bar elements and their connections were modeled using spring elements, with variable bending stiffness. The objective function was based on the search of the least stiff connection able to ensure the global stability of the building. Lastly, a connection model with optimal stiffness was adopted to design the frame. Semi-rigid beam-to-column connections with a constraint factors of 0.33 sufficed to ensure the maximum allowable horizontal displacement and bending moment of the connection, with a global stability parameter of 1.12. This confirms that even connections with low constraints generate significant gains from the structural standpoint, without affecting construction and assembly-related aspects.
Reinforced concrete bridge pier ductility analysis for different levels of detailing
Authors: SOARES R. W. , LIMA S. S. , SANTOS S. H. C.
Published: November 2017

Abstract The structural design under seismic loading has been for many years based on force methods to consider the effects of energy dissipation and elastoplastic behavior. Currently, displacement-based methods are being developed to take into account elastoplastic behavior. These methods use moment-curvature relationships to determine the ductility capacity of a structural element, which is the deformation capacity of the element before its collapse. The greater the plastic displacement or rotation a structural member can achieve before it collapses, the more energy it is capable of dissipating. This plastic displacement or rotation capacity of a member is known as the member ductility, which for reinforced concrete members is directly related to efficient concrete confinement. This study investigates at which extents transverse reinforcement detailing influences reinforced concrete column ductility. For this, a bridge located in Ecuador is modeled and analyzed, and its ductility evaluated considering several cases of axial loading and concrete confinement levels. After the performed displacement-based analyses, it is verified whether the response modification factor defined by AASHTO is adequate in the analyzed case.
Dynamics of haemocytes from Pseudosuccinea columella circulating infected by Fasciola hepatica
Authors: Ribeiro Vinicius Marques Antunes , Coaglio Aytube Lucas , Oliveira Fernando Luiz Pereira , Pereira Cíntia Aparecida de Jesus , Lima Walter dos Santos
Published: November 2017

Abstract The lymnaeids are important in the epidemiology of Fasciola hepatica, a neglected and endemic zoonosis. The interaction between the internal defense system of Pseudosuccinea columella and F. hepatica has been little studied. In the present study the effect of infection by F. hepatica on P. columella circulating haemocytes was investigated. Changes in the average number of total circulating haemocytes have been observed at 30 minutes post-infection and 1, 7, 10, 14, 21, 28 and 50 days post-infection (dpi). Miracidia were observed head-foot and mantle at 30 minutes post-infection. Miracidia/Sporocysts in the mantle skirt 1 dpi, and fully formed sporocysts were observed in the head-foot at 7 dpi. Rediae became evident at 10 dpi and were located between the haemocoel and the muscles from 14 dpi; 50 dpi, the rediae in the digestive gland contained cercariae. The statistical analysis of the total haemocytes of P. columella infected by F. hepatica showed significant differences on the 30 minutes post-infection and 1, 14, 21, and 28 dpi in comparison to uninfected molluscs (0 dpi). Therefore, the interference observed on the internal defence system of P. columella may have direct association with the development of F. hepatica.
Seasonality of parasitic helminths of Leporinus macrocephalus and their parasitism rates in farming systems in the Amazon
Authors: Martins Williane Maria de Oliveira , Justo Márcia Cristina Nascimento , Cárdenas Melissa Querido , Cohen Simone Chinicz
Published: November 2017

Abstract The objective of the present study was to analyze the seasonality of parasitic helminths of Leporinus macrocephalus from fish farms in the municipality of Cruzeiro do Sul, Acre, Brazil, and their parasitism rates. Between June 2014 and March 2015, 200 specimens were sampled from two fish farms: one with a semi-intensive system and the other with an extensive system (100 fish from each farm: 50 during the dry season and 50 during the rainy season). Fifteen species of parasites were found, with seasonal variations of some according to the farming system. In the semi-intensive fish farm, there was greater prevalence of infection during the dry season. Also, Urocleidoides paradoxus, Procamallanus (Spirocamallanus) inopinatus, Goezia leporini and Rhabdochona (Rhabdochona) acuminata presented differences in their parasitism rates between the seasons. In the extensive fish farm, no variation in the prevalence of infection was observed between the seasons and two species Tereancistrum parvus and G. leporini demonstrated differences only regarding the mean intensity of infection. The data presented here may help fish farmers to understand the parasite dynamics of L. macrocephalus in farming systems during the dry and rainy seasons in the state of Acre.
Co-infection with arthropod-borne pathogens in domestic cats
Authors: André Marcos Rogério , Filgueira Kilder Dantas , Calchi Ana Cláudia , Sousa Keyla Carstens Marques de , Gonçalves Luiz Ricardo , Medeiros Vitor Brasil , Ximenes Poliana Araújo , Lelis Ivana Cristina Nunes Gadelha , Meireles Maria Vanuza Nunes de , Machado Rosangela Zacarias
Published: November 2017

Abstract The role of several feline vector-borne pathogens (FVBP) as a cause of disease in cats has not been clearly determined. In fact, with the exception of Bartonella spp. and hemoplasmas, FVBP in cats has not been clearly determined in Brazil yet. The present study aimed at identifying, by using molecular methods, the presence of FVBP in three cats showing non-specific clinical signs and inclusions suggestive of hemoparasites in blood smears. Cytauxzoon felis, ‘Candidatus Mycoplasma haemominutum’, Ehrlichia sp. closely related to Ehrlichia canis, and Anaplasma sp. closely related to Anaplasma phagocytophilum were detected in blood samples from two out of three sampled cats. Both cats positive for multiple FVBP did not show hematological and biochemical abnormalities. The present work emphasizes the need for molecular confirmation of co-infection by multiple FVBP in cats presenting non-specific clinical signs and inclusions resembling hemoparasites in blood smears.
Potential of entomopathogenic nematodes of the genus Heterorhabditis for the control of Stomoxys calcitrans (Diptera: Muscidae)
Authors: Leal Luís Carlos de Souza Rodrigues , Monteiro Caio Márcio de Oliveira , Mendonça Alessandra Ésther de , Bittencourt Vânia Rita Elias Pinheiro , Bittencourt Avelino José
Published: November 2017

Abstract The present study verified the pathogenic potential of entomopathogenic nematodes (EPNs) of the genus Heterorhabditis (Heterorhabditis bacteriophora, isolate HP88 and Heterorhabditis baujardi isolate LPP7) to immature stages of Stomoxys calcitrans in the laboratory. All EPN concentrations of the H. bacteriophora HP88 strain caused mean larval mortality greater than 90% after four days. Higher concentrations of the H. baujardi LPP7 isolate (≥50 EPNs/larva) eliminated more than 70% of larvae after six days with the concentration 200 EPNs/larva reaching mortality levels of 93.3%. The larval mortality at all concentrations of EPNs (25, 50, 100, 150, and 200 EPNs/larva) for both strains was significant (p<0.05) when compared to the respective control groups. Concentrations of H. bacteriophora HP88 yielded an LC50 of 0.36 EPN/larva and LC90 of 29.1; while H. baujardi LPP7 yielded an LC50 of 39.85 and LC90 of 239.18. H. bacteriophora HP88 provided greater inhibition of the emergence of adults when compared to the response obtained with H. baujardi LPP7. EPNs did not cause considerable mortality when applied directly to pupae. The set of observed results suggests that the EPNs of the genus Heterorhabditis, isolates HP88 and LPP7, are a promising alternative in the control of the stable fly.
Estado e oligarquias na Primeira República: um balanço das principais tendências historiográficas
Authors: Ferreira Marieta de Moraes , Pinto Surama Conde Sá
Published: November 2017

Resumo Este artigo tem como objetivo discutir a literatura produzida entre os anos 1950 e 2000 sobre Estado e oligarquias na Primeira República brasileira (1889-1930). A proposta justifica-se em função da existência de um conjunto significativo de textos produzidos por especialistas de diferentes áreas sobre o tema. Como forma de contribuir para o avanço desse debate, pretendemos realizar um balanço mapeando as principais tendências observadas e indicando o que ainda precisa ser objeto de maior investigação por parte dos pesquisadores. Adotamos três critérios na triagem de trabalhos discutidos: a inclusão no universo de análise de livros e artigos produzidos na área das ciências sociais com enfoque histórico, considerados clássicos, que permanecem como referências importantes; uma bibliografia mais atual, ou seja, livros e artigos que retomam essas interpretações para, a partir delas, renovar determinadas chaves de leitura; e a não inclusão de teses (salvo casos excepcionais) e textos de época.
Azacitidine in Lower-Risk Myelodysplastic Syndromes: A Meta-Analysis of Data from Prospective Studies
Authors: Komrokji Rami , Swern Arlene S. , Grinblatt David , Lyons Roger M. , Tobiasson Magnus , Silverman Lewis R. , Sayar Hamid , Vij Ravi , Fliss Albert , Tu Nora , Sugrue Mary M.
Published: November 2017

Background

After erythropoiesis-stimulating agent (ESA) failure, lenalidomide and hypomethylating agents are the only remaining treatment options for most patients with lower-risk myelodysplastic syndromes (LR-MDS). Optimal choice of these agents as front-line therapy in non-del(5q) LR-MDS is unclear. Because azacitidine clinical data mainly describe experience in higher-risk MDS, we performed a meta-analysis of patient-level data to evaluate azacitidine in patients with red blood cell (RBC) transfusion-dependent LR-MDS.

Materials and Methods

We searched English-language articles for prospective phase II and III azacitidine clinical trials and patient registries published between 2000 and 2015, and Embase abstracts from 2015 conferences. Patient-level data from identified relevant studies were provided by investigators. Meta-analyses followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Efficacy endpoints were RBC transfusion independence (TI) and Clinical Benefit (RBC-TI, erythroid response, and complete or partial remission, per International Working Group 2006 criteria for MDS).

Results

Data for 233 patients from 6 clinical studies and 1 registry study met criteria for inclusion in analyses. Overall, 90.3% of patients had non-del(5q) LR-MDS. Pooled estimates from random-effects models of RBC-TI and Clinical Benefit were 38.9% and 81.1%, respectively; for the ESA-refractory subgroup, they were 40.5% and 77.3%; and for patients with isolated anemia, they were 41.9% and 82.5%. In multivariate analyses, planned use of ≥6 azacitidine treatment cycles was significantly predictive of response.

Conclusion

Azacitidine effects in these patients, most with non-del(5q) LR-MDS, were promising and generally similar to those reported for lenalidomide in similar patients. The choice of initial therapy is important because most patients eventually stop responding to front-line therapy and alternatives are limited.

Implications for Practice

Lower-risk myelodysplastic syndromes (LR-MDS) are primarily characterized by anemia. After erythropoiesis-stimulating agent (ESA) failure, lenalidomide and hypomethylating agents are the only remaining treatment options for most patients. This meta-analysis of 233 azacitidine-treated red blood cell (RBC) transfusion-dependent patients with LR-MDS (92.3% non-del[5q]) from 7 studies showed 38.9% became RBC transfusion-independent. There is no clear guidance regarding the optimal choice of lenalidomide or hypomethylating agents for patients with non-del(5q) LR-MDS following ESA failure. Clinical presentation (e.g., number of cytopenias) and potential outcomes after hypomethylating agent failure are factors to consider when making initial treatment decisions for LR-MDS patients.
Clinical Usefulness of 18F-Fluorodeoxyglucose Positron Emission Tomography in the Diagnostic Algorithm of Advanced Entero-Pancreatic Neuroendocrine Neoplasms
Authors: Rinzivillo Maria , Partelli Stefano , Prosperi Daniela , Capurso Gabriele , Pizzichini Patrizia , Iannicelli Elsa , Merola Elettra , Muffatti Francesca , Scopinaro Francesco , Schillaci Orazio , Salgarello Matteo , Falconi Massimo , Delle Fave Gianfranco , Panzuto Francesco
Published: November 2017

Background

The role of 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) in the diagnostic algorithm of entero-pancreatic neuroendocrine neoplasms (EP NENs) is unclear because most available data derive from heterogeneous populations in terms of tumor biology and disease status at time of examination. The aim of this study was to determine the ability of 18F-FDG PET to identify patients with more aggressive disease among those with advanced EP NENs.

Subjects, Materials, and Methods . Patients with advanced EP NENs and known disease status (progressive disease [PD] or stable disease [SD]) according to imaging procedures, who received 18F-FDG PET and computed tomography scans during a time frame of 1 month, were included.

Results

A total of 93 patients, including 69 patients with pancreatic NENs and 24 patients with small-intestine NENs, were included. At the time of study entry, 64 patients (68.8%) had PD, and the remaining 29 patients (31.2%) had SD. A total of 62 patients (66.7%) had positive 18F-FDG PET, whereas 18F-FDG PET was negative in the remaining 31 patients (33.3%). Overall, 18F-FDG PET sensitivity and specificity to detect PD were 90.6% and 86.2%, respectively, resulting in a diagnostic accuracy of 89.2%. A positive 18F-FDG PET was significantly associated with PD at the time of study entry (p < .0001 at multivariate analysis). Although a higher proportion of 18F-FDG PET-positive examinations were observed in patients with higher tumor grade (p = .01), 53.8% of patients with grade 1 neuroendocrine tumors (NETs) had positive 18F-FDG PET, and 37.5% of patients with grade 2 NETs had negative 18F-FDG PET. Overall survival was significantly shorter in 18F-FDG PET-positive patients (median: 60 months) in comparison with 18F-FDG PET-negative patients (median not reached; p = .008).

Conclusion

18F-FDG PET has a high diagnostic accuracy to identify progression of disease with unfavorable clinical outcome in patients with advanced EP NENs. Knowledge of disease status and G grading are key factors for physicians to better select patients for whom 18F-FDG PET is clinically useful.

Implications for Practice

The findings of the present study may help physicians dealing with advanced neuroendocrine neoplasms to select patients for whom 18F-fluorodeoxyglucose positron emission tomography is useful to predict poor clinical outcome.
Improving potassium recovery with new solubility product values for K-struvite
Authors: Bennett Aline M , Lobanov Sergey , Koch Frederic A , Mavinic Donald S
Published: November 2017

Crystallisation of ammonium (NH4) struvite is a viable method of recovering valuable nutrients such as nitrogen and phosphorus from waste waters. Little work has been done on potassium (K) recovery since neither is it an environmental pollutant nor is society facing global potassium shortages. However, potassium is an essential plant macronutrient, worldwide imbalances in nutrient and fertiliser use exist and there is a need for a slow-release potassium fertiliser. The goal of this research was to develop a fundamental understanding of K-struvite formation as the first step in recovering potassium to allow for producing a full complement nitrogen–phosphorus–potassium slow-release fertiliser from waste waters. Specific objectives included determination of solubility product values for K-struvite at 10, 25 and 35°C. By using these values, optimal supersaturation conditions for K-struvite precipitation were modelled using aqueous equilibrium modelling software and subsequently validated by experiment. The new solubility product values confirmed that K-struvite was less soluble than previously reported. This research adds to the body of literature in nutrient recovery by furthering the understanding of K-struvite formation.
An experimental investigation into the micromechanics of non-active clays
Authors: Pedrotti M. , Tarantino A.
Published: November 2017

The paper presents an experimental investigation into the micro-mechanisms controlling the behaviour of non-active clays. Clay microstructural behaviour was investigated by way of mercury intrusion porosimetry (MIP) accompanied by scanning electron microscope images. To gain insight into the mechanisms underlying reversible and non-reversible compression, samples for MIP testing were taken along both normal compression and unloading–reloading lines. To investigate the nature of inter-particle forces, the response of clay samples prepared with deionised water (characterised by acidic pH) was compared with clay samples prepared with alkaline water. A high pH ‘deactivates’ the edge-to-face contacts that are indeed active in the clay prepared with deionised (acidic) water. The pore size distribution data clearly highlighted that the smaller pores are associated with particles in non-contact configuration, that is only interacting by way of the overlap of the repulsive electrical field generated by the negatively charged faces. On the other hand, larger pores are associated with contact configuration, generated by the attraction between the positively charged edge and the negatively charged face of the clay particle. The pore size distribution data also made it possible to infer that reversible behaviour is mainly associated with the reversible overlap of the repulsive electrical field in contact configuration, whereas the plastic response appears to be associated, at the micro-scale, with the loss of edge-to-face contacts. Finally, an embryonic one-dimensional discrete-element method (DEM) model was developed to show the potential of the micromechanical conceptual model to be implemented into a DEM model.
Critical success factors in a public–private partnership highway project in Malaysia: Ampang–Kuala Lumpur Elevated Highway
Authors: Ghazali Mohamed , Rashid Abd , Sadullah Mohd
Published: November 2017

The Ampang–Kuala Lumpur Elevated Highway, which is also known as Akleh, is the first elevated highway-infrastructure project that has been procured in Malaysia through the public–private partnership approach. Even though the construction stage of the project has taken 5 years to complete, which is much longer than what is required for a normal construction project, Akleh was successfully commissioned for operation in 2001. This paper identifies and ranks the critical success factors of the first elevated highway-infrastructure project in Malaysia. All the key contributing factors that have been identified can be grouped into five critical success factors. All factors are ranked from the most critical factor that has the most impact on the success of the project. Extensive interviews with key personnel from both the project’s clients and the project concessionaire were carried out to establish what those involved in the project considered to be the critical success factors, and produce a ranking of those factors. As a result, project implementability, judiciary government control and transparent procurement process are among the most prioritised critical success factors. Effective management control, good communication between project parties and stable political situation are identified as the top three contributing factors.
Yeast Crude Protein Extraction v2
Authors: Cone Alan
Published: November 2017

Quick crude protein extraction from budding or fission yeast.
Fluorescent Focus Unit Assay using LICOR Imaging System v1
Authors: Mainou Bernardo
Published: November 2017

Indirect immunofluorescence infectivity assay for reovirus using LICOR Imaging System
Reovirus Viral Purification v1
Authors: Mainou Bernardo
Published: November 2017

Purification of mammalian orthoreovirus by CsCl gradient
The Effect of Different Addition of Jicama (Pachyrhizus erosus) Extract to the Value of Total Lactic Acid Bacteria, Chemical Properties and Organoleptic in Soyghurt
Authors: Nabila Asharina , Bintoro Valentinus Priyo , Al-Baarri Ahmad Ni'matullah
Published: November 2017

This research aims to know the effect of addition of jicama extract with different concentration to the value of total lactic acid bacteria, chemical properties, and organoleptic in soyghurt sinbiotic. Experiment design that used in this research was experiment using complete random design with 4 treatments; i.e. concentration of jicama extract of 0%, 15%, 25%, and 35%. As result, jicama extract effected to total lactic acid bacteria, total solid, acidity, and organoleptic. The higher concentration of jicama extract the higher total lactic acid bacteria, total titratable acidity and acidity organoleptic. However, the total solid and mouthfeel organoleptic was decrease against the elevation of jicama extract.
A literatura indígena como crítica da modernidade
Authors: Danner Leno Francisco , Dorrico Peres Julie Stéfane
Published: November 2017

Este texto realiza uma discussão entre literatura e filosofia-sociologia com base na correlação entre o paradigma normativo da modernidade, na versão de Weber e de Habermas, e a posição xamânica de Davi Kopenawa, com o intuito de refletir sobre os conceitos de crítica, emancipação e universalismo. A razão de tal discussão é bem direta: o paradigma normativo da modernidade fala do xamanismo como antípoda da racionalização, ao passo que, no caso de Davi Kopenawa, o xamanismo é exatamente uma voz-práxis crítica da modernidade. No mesmo sentido, o paradigma normativo da modernidade defende que a crítica, a reflexividade, a emancipação e o universalismo somente são possíveis por meio desse mesmo paradigma, em suas características de formalização, neutralidade, imparcialidade e impessoalidade. Em contrapartida, no xamanismo explicitado e representado por Davi Kopenawa, é possível perceber-se que a crítica, a reflexividade e a emancipação são dadas e viabilizadas exatamente pela vinculação sociocultural e pela pertença antropológico-ontológica – o xamanismo é crítico da modernidade como xamanismo, desde si mesmo. Com base nessa discussão, o artigo argumentará que, no caso das minorias, é somente por meio de sua voz-práxis como diferenças e a partir de sua singularidade que a sua reafirmação e a sua consequente crítica à modernidade são possíveis. É questão de vida e de morte, portanto, para essas mesmas minorias, assumir-se, constituir-se e dinamizar-se como minorias. Para isso, a literatura, em sua estrutura antiparadigmática e antiformalista, muito mais do que o racionalismo científico, pode servir como voz-práxis das diferenças, por elas, para elas.
dúvidas póstumas de Félix
Authors: Cei Vitor
Published: November 2017

O artigo propõe uma análise do primeiro romance de Machado de Assis, Ressurreição, com base nos conceitos filosóficos de ressentimento e ascetismo. O objetivo é argumentar que o ciumento protagonista Félix, ao sofrer com “dúvidas póstumas”, assemelha-se ao “homem do ressentimento” e ao “asceta”, tipos fisiopsicológicos estudados por Nietzsche em Genealogia da moral e ficcionalizados por Machado em Dom Casmurro e Memorial de Aires, respectivamente. Félix, assim como Bento Santiago, é um sujeito ciumento refém de seu passado e de suas marcas, desprovido daquela que seria a autêntica ação (a afirmativa), restando-lhe somente a reação, que consiste numa espécie de autoenvenenamento que o devora por dentro. E, tal qual o Conselheiro Aires, Félix pratica um ascetismo sui generis, evitando contaminar-se emocionalmente com relações afetivas. Veremos que os tipos nietzschiano e machadiano mostram-se complementares na discussão sobre o lugar de Félix no universo ficcional de Machado, de modo que sua comparação oferece uma contribuição para uma renovada compreensão das dimensões literária e filosófica de Ressurreição.
Sozinho entre as árvores
Authors: Gabriel Maria Alice Ribeiro
Published: November 2017

Textos autobiográficos e memorialísticos fornecem leituras para campos de pesquisa interdisciplinares. Histórias de fantasmas apresentam fronteiras históricas, sociais e emocionais, e conectam pessoas a sentimentos contraditórios, tais como medo e nostalgia. Este artigo pretende discutir a relação entre narrativa oral e literária em Baú de ossos (1972) e Balão cativo (1973), de Pedro Nava, empregando uma perspectiva literária em relação ao material folclórico correspondente. Uma análise crítica dos relatos expostos pelo memorialista revela que determinados aspectos dos fabulates e memorates são descritos como sendo factuais e outros provavelmente enraizados na cultura popular. Com o propósito de conceder voz às fontes de tais testemunhos, o autor modifica suas estratégias narrativas, as quais exploram as reações dos contadores de histórias a fantasmas e aparições.
Álbum de Caliban
Authors: Mendes Leonardo
Published: November 2017

A partir de 1880, configura-se no Brasil um espaço novo de circulação de histórias licenciosas. O impresso pornográfico começa a aparecer nos anúncios de livrarias nos jornais de grande circulação. Surgem novos editores e livrarias, como a Livraria do Povo e a Livraria Moderna. A percepção de que havia um mercado para esse gênero de literatura era crucial para a decisão dos editores de investir nessas edições. Sob o pseudônimo Caliban, da peça A Tempestade (1611), de William Shakespeare, Coelho Neto criou uma persona para atender à demanda de literatura pornográfica, fabricando contos e crônicas licenciosos que foram publicados nos jornais de todas as regiões do país até o começo do século XX. Entre 1897 e 1898, os textos foram editados pela Livraria Laemmert em fascículos e reunidos no volume Álbum de Caliban. Neste estudo, vamos conhecer a faceta de autor licencioso de Coelho Neto e investigar sua atuação no incipiente mercado de literatura pornográfica na Primeira República.
Clarice Lispector e as fronteiras do Nada
Authors: Bezerra Cicero Cunha
Published: November 2017

Sobre as fronteiras que circundam a relação entre a filosofia e a literatura existe uma vasta bibliografia que justifica o diálogo entre esses dois campos de saberes que, ao longo de muito tempo, seja pela resistência da filosofia em conceder valor aos textos literários como solos profícuos de construções de conhecimentos, seja pela liberdade literária em não se deixar dominar por um método em que a lógica e a racionalidade seriam seus fios condutores, mantiveram-se em margens academicamente antagônicas. O cenário atual, felizmente, gradativamente vem superando essa cisão e estabelecendo interfaces criativas e rigorosas. Este trabalho tem, assim, o objetivo de aproximar esses dois saberes apoiado em uma ideia desafiadora em ambos os casos: o nada. Para tanto, busco pensar mediante uma tradição específica (o Neoplatonismo) alguns romances de Clarice Lispector nos quais o “nada” figura como imagem nuclear. Com isso, a filosofia e a literatura pisam em um mesmo território marcado pelo desafio de pensar as fundamentações de suas reflexões, precisamente, pela ausência de fundamentos.
Considerações sobre a literatura de Hilda Hilst e Samuel Beckett com base na crítica filosófica da linguagem de Fritz Mauthner
Authors: André Willian
Published: November 2017

Este artigo tem por objetivo propor um diálogo entre alguns aspectos da produção literária dos escritores Hilda Hilst e Samuel Beckett, tomando como principal fundamentação teórica a crítica filosófica da linguagem traçada por Fritz Mauthner em seu Beiträge zu einer Kritik der Sprache, publicado originalmente entre 1901 e 1902. Ainda que outros textos dos dois escritores sejam eventualmente mencionados, serão esboçadas análises mais específicas de duas narrativas curtas: “Vicioso Kadek” (1977), de Hilst, e “Imagination Morte Imaginez” (1965), de Beckett. Apesar de visivelmente distintos em sua proposta estética, ambos os textos apontam para uma linguagem que se descobre incapaz de significar de maneira satisfatória, por meio de situações de incomunicabilidade vividas por seus personagens ou descrições sofríveis que acabam limitadas à condição de gaguejos. Esse impasse encontra ecos na filosofia de Mauthner, cujo ensaio versa sobre as limitações da linguagem.
Panther, K-U., and Thornburg. Eds. 2003. "Metonymy and pragmatic inferencing". Amsterdam/Philadelphia: John Benjamins. 280 pp.
Authors: Herrero Ruiz Javier
Published: November 2017

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