bluuebunny/crossref_metadata_2025 huggingface dataset:
THE EFFECT OF WORK SATISFACTORY ON TURN OVER INTENTION AND ORGANIZATIONAL COMMITMENT AS WELL AS ITS IMPACT TOWARD EMPLOYEE PERFORMANCE AT PT. BANK SULTENG
Authors: Prilly Rumbajan Mouren Happy , Hasanuddin Bakrie , Asngadi Asngadi
Published: June 2023

This research intends to determine and to analyze the direct effect of work satisfaction on turn over intention and organizational commitment and its impact on the performance of employees at PT. Central Sulawesi Bank. The population consists of 87 people who are employees at Head Office PT. Bank Sulteng taken from all levels of employees. Data analysis in this research used Structural Equation Model (SEM). The results of the analysis using the SmartPLS ver 3.0 statistical tool reveals that work satisfaction has a positive and significant effect on tur nover intention. Work satisfaction has a positive and significant effect on organizational commitment. Work satisfaction has a positive and significant effect on employee performance. Turn over intention has a positive and significant effect on employee performance. Organizational commitment has a positive and significant effect on employee performance. Work satisfaction has a positive and significant effect on performance through turn over intention as an intervening variable. Work satisfaction has a positive and significant effect on employee performance through organizational commitment as an intervening variable.

 

Keywords: Work satisfaction, Turn over Intention, Organizational Commitment, Performance
ANALYSIS OF THE INFLUENCE OF REGULATION AND MANAGEMENT INFORMATION SYSTEM ON ASSET MANAGEMENT (EMPIRICAL STUDY ON UPT RADIO SPECTRUM MONITORING, DIRECTORATE-GENERAL OF POSTS AND INFORMATICS RESOURCES)
Authors: Imalia Norma , Mattulada Andi , Haris Nurhayati
Published: June 2023

This research aimed to determine the effect of Regulation and Information Systems on Asset Management. This research applied multiple regression analysis method where sampling technique used systematic sampling with purposive sampling. Based on the results of statistical tests, regulations and information systems have an influence on asset management at the UPT Radio Frequency Spectrum Monitoring, Directorate-General of Posts and Informatics Resources. The regulation partially has an influence on asset management at the UPT Radio Frequency Spectrum Monitoring, Directorate-General of Posts and Informatics Resources. The information system partially has an influence on asset management at the UPT Radio Frequency Spectrum Monitoring, Directorate-General of Posts and Informatics Resources.

Keywords: Regulation, Information Systems, Asset Management.
THE EFFECT OF PRICE, SERVICE AND PROMOTION ON REPURCHASE DECISION OF WATER REFILLS PRODUCT OF METRO PALU
Authors: Nurmiati Nurmiati , Miru Sulaeman , Santi Ira Nuriya
Published: June 2023

This research aims to determine and analyze the effect of price, service, and promotion simultaneously and partially on decision to repurchase the product of water refills of Metro Palu. The population in this research were all customers of the Metro Palu refill water refills station. The number of samples in this research were 123 respondents. This research applied a descriptive causal with data analysis technique using multiple linear regression. Data were analyzed through SPSS application. The results show that the variables of price, service and promotion simultaneously have a positive effect on repurchase decisions, the significant value of F is 0.000 < (0.05). Moreover, the partial test result obtains that the price variable has a significant value of t = 0.006 < (0.05). It can be concluded that the price variable positively and significantly affects on repurchase decision. Furthermore, the service variable has a significant value of t = 0.006 < (0.05) so it can be concluded that the service variable has a positive and significant effect on repurchase decision. The results of the partial test show that the promotion variable has a significant value of t = 0.000 < (0.05). Thus, so it can be concluded that the promotion variable has a positive and significant effect on repurchase decision.

 

Keywords: Prices, Services, Promotions, Repurchase Decisions, Metro Palu Water Refills
CAPITAL STRUCTURE ANALYSIS IN MINING COMPANIES LISTED IN INDONESIA STOCK EXCHANGE
Authors: Sulistianingsi Nilla , Nofal Mohammad , Hatma Ramli
Published: June 2023

This research aims to analyze the capital structure of mining companies listed on the Indonesia Stock Exchange by examining 4 fundamental factors, namely Asset Structure, Profitability, Sales Growth and Company Size. The research sample was 41 mining companies on the Indonesia Stock Exchange in 2016-2020. For the panel data regression analysis technique, Software Econometric Views (Eviews) version 12 was used.  Based on the results of the analysis, the direct influence is concluded that 1) Asset Structure, Profitability, Sales Growth and Company Size simultaneously have a positive and significant effect on the company's capital structure Mining on the Indonesia Stock Exchange for the period 2016-2020; 2) Asset structure has no significant positive influence on capital structure; 3) Profitability has a negative and significant effect on capital structure; 4) Sales growth has a negative and insignificant influence on capital structure; and 5) Company size has a negative and significant effect on the capital structure of mining companies listed on the Indonesia Stock Exchange in 2016-2020.

Keywords: Capital Structure, Asset Structure, Profitability, Sales Growth and Company Size
Production maximization of rainy season rice (Oryza sativa) through effective use of water and solar radiation under modified system of rice intensification in Assam
Authors: R. KALITA  , R.K. THAKURIA  , B.K. MEDHI  , M. SAIKIA
Published: June 2023

A field experiment was conducted in a farmers’ field at Nepalikhuti, Golaghat, Assam during the rainy (kharif) season of 2016 and 2017, to find out the effect of different transplanting dates and hill densities of rice (Oryza sativa L.) under system of rice intensification (SRI) which was compared with conventional rice cultivation (CRC). The experiment was designed in factorial split-plot with 2 crop-establishment methods (SRI and CRC) and 3 transplanting dates (26 June, 10 and 25 July) in the main plot; and 4 different hill densities (20 cm × 10 cm, 20 cm × 20 cm, 25 cm × 20 cm and 25 cm × 25 cm) in the subplots and replicated thrice. With an increased grain yield of 5.71 t/ha, SRI-establishment showed a significant yield advantage of 0.83 t/ha coupled with 2.64% more consumptively used water and 1.29 kg/ha-mm more water-use efficiency over CRC. Results showed strong positive correlation (0.95**) between water-use efficiency (WUE) and yield attributes primarily the effective tillers/m2. Regression analysis revealed that irrespective of establishment methods, the consumptive use (CU) of water, accumulated incident photosynthetically active radiation (AIPAR), radiation-use efficiency (RUE) and heat-use efficiency (HUE) greatly influenced the grain yield. However, in SRI, WUE appeared to be an additional key determinant of grain yield. Between 2 establishment methods, SRI was found to be more competent in utilizing water and solar radiation owing to its ideal canopy environment.
Response of alley-cropped pearl millet (Pennisetum glaucum) to nitrogen and zinc schedules under semi-arid regions
Authors: KAMLESH VERMA  , S.K. PRASAD  , M.K. SINGH  , PRASHANT SHARMA
Published: June 2023

Realizing the importance of tree-based cropping system and scheduling of nitrogen (N) and zinc (Zn) in the semi-arid region, an on-field trial was conducted with pearl millet [Pennisetum glaucum (L.) R. Br.] during the rainy season of 2017 at RGS Campus of Banaras Hindu University, Mirzapur, Uttar Pradesh. The trial was laid out in factorial randomized block design with 4 N and 4 Zn treatment applications in different schedules. The results revealed that, N scheduled at ¼ [basal] + ½ (3rd visible leaf (VL) + ¼ panicle extended in flag-leaf sheath (PEFLS) produced the most synergetic effect on growth and yield of pearl millet. The grain yield increased up to 65% compared to no N application. Conversely, Zn schedules did not significantly influence the growth parameters (except dry-matter), while Zn application at 2.5 kg/ha (basal) + 0.25% panicle initiation (PI) + 0.25% PEFLS recorded about 37% more grain yield, than no Zn application. Additionally, the maximum biological and straw yields recorded with 2.5 kg/ha (basal) + 0.25% panicle emergence (PE) + 0.25% milk stage (MS) Zn application compared to the other treatments. Moreover, N and Zn interacted significantly to produce synergetic effect on the dry-matter, test weight, grain, straw, and biological yields. The maximum grain yield was observed with conjunctive application of N at ¼ [basal] + ½ [3rd VL] + ¼ [PEFLS] and Zn at 2.5 kg/ha [basal] + 0.25% [PI] + 0.25% [PEFLS], whereas the maximum biological and straw yields were recorded with application of the N at ¼ [basal] + ½ [3rd VL] + ¼ [PEFLS] and Zn at 2.5 kg/ha [basal] + 0.25% [PE] + 0.25% [MS].
FRAUD RISK ASSESSMENT PADA FUNGSI RELIABILITY & PROJECT DEVELOPMENT PT ABC
Authors: Sihotang Edi
Published: June 2023

Keberhasilan perusahaan dalam mengelola usahanya sangat tergantung terutamadari top manajemen. Satu dari beberapa prinsip dari top manajemen adalah komitmen terhadap integritas. Perilaku Tidak Etis merupakan penyimpangan perilaku yang tidak sesuai dengan prinsip tata kelola yang baik. Salah satu perilaku tidak etis yang mempengaruhi tujuan perusahaan adalah fraud(kecurangan). Fraud sering kali tidak disadari oleh perusahaan karena sifatnya yang tersembunyi. Berdasarkan hasil penelitian Report to the Nations on Occupational Fraud and Abuse tahun 2020, kerugian perusahaan yang disebabkan oleh fraud sekitar 5% dari penghasilan. Mengingat dampak dari terjadinya fraud terhadap perusahaan begitu besar, banyak cara atau metoda diupayakan guna dapat mengurangi atau bahkan menghilangkan fraud tersebut. Salah satu cara yang paling dominan guna dapat mencegah fraud adalah dengan mengidentifikasikan jenis-jenis risiko fraud yang besar kemungkinan terjadi dalam suatu unit atau entitas. Kemudian risiko-risiko tersebut dilakukan penilaian. Proses proaktif yang bertujuan untuk menidentifikasikan dan mengatasi kerentanan organisasi atas kecurangan yang dilakukan pihak internal ataupun pihak eksternal dikenal dengan Fraud Risk Assessment (FRA). Fungsi RPD adalah salah satu pilar organisasi PT. ABC yang mengelola proyek strategis dengan nilai anggaran investasi pada tahun 2019 mencapai Rp 4,9 Triliun. Sejalan dengan pengelolaan proyek tersebut, berdasarkan Laporan Hasil Audit Tujuan Tertentu tahun 2016 s.d 2019, masih terdapat perilaku menyimpang (fraud) yang dilakukan oleh pekerja RPD. Oleh karenanya, kajian terkait pelaksanaan Fraud Risk Assessment di Fungsi RPD penting dilakukan
Efektivitas Penagihan Pajak dengan Surat Paksa dan Penyitaan di KPP Pratama Pondok Gede
Authors: Lolo Donald , Oentoeng Irvan
Published: June 2023

Tujuan dari penelitian ini adalah untuk mengetahui efektivitas penagihan pajak dengan surat paksa dan penyitaan di KPP Pratama Pondok Gede. Hasil penelitian adalah kontribusi pencairan tunggakan pajak dengan Surat Paksa dan Penyitaan terhadap penerimaan pajak di KPP Pondok Gede tahun 2018 sampai dengan 2020 berdasarkan pengujian dengan yang telah dihitung menggunakan rumus efektivitas masih tergolong kurang efektif karena semua hasilnya masih dibawah 60%.
PENGARUH MANAJEMEN RESIKO, SOLVABILITAS, DAN UKURAN PERUSAHAAN TERHADAP NILAI PERUSAHAAN SEKTOR KONSTRUKSI, PROPERTI DAN REAL ESTATE YANG TERDAFTAR DI BEI
Authors: Hotang Keri Boru , Sentosa Maliki Heru , Muslih Mochamad , Apriani Indah , Apriani Indah
Published: June 2023

Penelitian ini dilakukan untuk mengetahui pengaruh dari variabel Manajemen Risiko, Solvabilitas, dan Ukuran Perusahaan terhadap Nilai Perusahaan. periode yang digunakan dalam penelitian ini pada tahun 2016-2020. Penelitian ini menggunakan metode kuantitatif. Model penentuan sampel menggunakan metode purposive sampling. Sampel yang digunakan dalam penelitian ini yaitu 37 perusahaan dari sektor konstruksi, properti dan real estate yang terdaftar di Bursa Efek Indonesia selama periode penelitian. Data pengolahan dilakukan dengan menguji analisis statistic deskriptif, uji asumsi klasik, uji normalitas, uji multikolinearitas, uji heteroskedastisitas, uji korelasi, analisis regresi linear berganda, dan uji hipotesis. Variabel dependen dalam penelitian ini adalah Nilai Perusahaan, dan variabel independen terdiri dari Manajemen Risiko, Solvabilitas, dan Ukuran Perusahaan. Metode penelitian ini menggunakan perangkat lunak SPSS versi 25. Hasil penelitian ini menunjukan, Manajemen risiko memiliki pengaruh positif dan signifikan terhadap Nilai Perusahaan dengan nilai signifikasinya sebesar 0,000, Solvabilitas berpengaruh positif dan signifikan terhadap Nilai Perusahaan dengan nilai signifikanya sebesar 0,007, dan  Ukuran Perusahaan tidak berpengaruh terhadap Nilai Perusahaan dengan nilai signifikanya sebesar 0,573.
Cloud test data creation and population document :
Authors: Ayers Richard
Published: June 2023

This test data creation and population document provides an overview of data creation, population and documentation of artifacts created for cloud-based applications specified in Version 1 of Cloud & Remotely Stored Data Extraction (CDX) Using Account Credentials: Specification, Test Assertions, and Test Cases. Due to the frequency of application updates that may occur during testing, it is advised to document the version number of the current application under test to maintain the fairness and integrity of the tool verification process. Comments and feedback are welcome. This document, and future revisions, are available for download at: https:\\www.cftt.nist.gov.
Brill and Open Access
Authors: Veldman Stephanie , Van Dijk Arjan , Aspaas Per Pippin
Published: June 2023

An online conversation with two representatives of Brill, a publisher that is particularly strong in the Humanities and Social Sciences. A 340-year-old publishing house, Brill still primarily sells books and journals in a traditional manner, i.e. as hardcopies and online fulltexts behind a paywall. Currently, Brill has a total output of around 1,400 academic books per year. Just over 10% of these titles are published in Open Access thanks to authors (or their institutions) paying a Book Processing Charge (BPC). Among its 300+ peer-reviewed journals, approx. 10% are published according to the Diamond Open Access model, meaning that some sort of sponsorship allows Brill to offer its services with no author- or reader-facing charges. In the discussion, Open Research Officer Stephanie Veldman explains the economic mechanisms and strategic thinking behind Brill’s work in the field of open access. Publishing director for History, Social Sciences and Biology Arjan van Dijk highlights the author’s and editor’s perspectives, using the successful Journal of Jesuit Studies (launched in 2013) as a concrete example. Both Veldman and van Dijk see it as an important part of their mission to increase the proportion of books and journals that are published in open access.
First published online: June 7, 2023.
Resíduos sólidos na construção civil no Brasil
Authors: Cunha Késia da Silva , Roberto José Carlos Alves , Souto Sistina Pereira , Lima Suelen Costa
Published: June 2023

Contexto: os resíduos de construção e demolição (RCD) provêm de atividades de engenharia. No Brasil, milhares de toneladas de RCD são gerados diariamente, e muitas vezes são descartados clandestinamente em terrenos baldios, margens de rios e periferias das cidades. A maior parte dos RCD gerados nas cidades brasileiras poderia ser totalmente reciclada. Pergunta problema: como é realizada a gestão dos RCD no Brasil, em especial a coleta e a reciclagem dos RCD? Objetivo Geral: este estudo tem como objetivo traçar um panorama sobre a gestão dos RCD no Brasil. Metodologia: este estudo foi desenvolvido utilizando o método de abordagem dedutiva para analisar os RCD em relação às políticas públicas, classificação, coleta e gestão no Brasil. Procedeu-se ainda a uma análise exploratória por meio da pesquisa de dados bibliográficos de natureza qualitativa através da consulta de artigos de revistas, teses e dissertações. Principais resultados: os resultados mostraram que os RCD no Brasil são, em geral, compostos de argamassa, concreto, madeira e vidro, sendo que tais resíduos são dispostos nos canteiros de obras de forma desordenada e misturada. A gestão dos RDC é incipiente e os materiais reciclados carecem de um controle de qualidade mais eficaz para uso em larga escala. Há desigualdade na gestão dos RCD entre as regiões brasileiras. A região sudeste possui 65% das usinas de reciclagem, enquanto na região norte não há nenhuma. Quanto aos RCD coletados, a região sudeste coleta 52,1% do total e a região norte apenas 3,9%. Conclusões: concluiu-se que é necessário um engajamento mais efetivo do governo brasileiro para melhorar tanto o sistema de coleta quanto as práticas de reciclagem. O modelo desejável de gestão dos RCD a ser alcançado é reduzir o volume gerado e, para o excedente, reciclar o máximo possível.
A Primary Care Mental Health Pathway for Children and Youth: A Mental Health Services Quality Improvement Initiative in Ontario
Authors: Polihronis Christine , Ziebell Laura , Cloutier Paula , Radomski Ashley , Sundar Purnima , Cappelli Mario
Published: June 2023

We introduce the innovative components of a primary care pathway for child and youth mental health (MH) in Ontario. We share our experiences with developing and implementing the pathway that supports inter-provider communication, standardized screening, timely access to community MH services, and is adaptable to different services and settings.
Effect of Heat Curing of Film-forming Solution on the Properties of Soy Protein Films
Authors: Bari Tasmia , Monirujjaman Md. , Akter Farzana , Alam Md. Shahriar
Published: June 2023

This study aimed to investigate the impact of heat treatment on the properties of soy protein isolate film-forming solutions. The solutions, consisting of soy protein isolate, glycerol, and phosphate buffer solution (pH 7.4), were subjected to heat treatment at 65, 75, and 85°C for 2, 4, or 6 h. The resulting films were then analyzed for tensile strength, elongation at break, film solubility, color parameters, and transparency. The results indicated that increasing the heat-curing temperature increased tensile strength, film transparency, and yellowish color in the films, as well as decreased water solubility and elongation at break. Notably, the film cured at 85°C for 2 h exhibited the highest tensile strength, film solubility, and elongation at break compared to both the control and other heat-cured films. However, the film heated at 75°C showed a better elongation at break. Overall, the findings suggest that heat curing of film-forming solutions at temperatures between 75 and 85°C has the potential to improve the properties of soy protein isolate films.
The Effect of Transformational Leadership on Readiness for Change Mediated by Organizational Commitment
Authors: Adiwijaya Singgih , Ribhan  , Hayati Keumala
Published: June 2023

The purpose of this study was to determine the effect of transformational leadership on readiness  to  change  and  organizational  commitment  as  a  mediating  variable  between transformational  leadership  and  readiness  to  change  at  Central  Bureau  of  Statistics  in Lampung Province. The analytical tool used is SEM - PLS. The number of samples is 138 with Stratified Random sampling method. The results of this study found that transformational leadership had a significant positive effect on readiness to change and transformational leadership had a significant positive effect on organizational commitment, organizational commitment had a positive effect on readiness to change. This study found that organizational commitment variables mediated the influence of transformational leadership on readiness for change. The results of the study show that there are several suggestions that can be given for Central Bureau of Statistics in Lampung Province, namely the initiative of leaders to criticize in terms of decision making, the need for increased commitment from employees who are always in the Central Bureau of Statistics in Lampung Province environment, prioritizing organizational activities and the presence of full support from leaders so that readiness employees to change for the better.
Physical Characteristics Content Evaluation of Feed Containing Termite as a Potential Alternative for Fish Feed
Authors: Marela Haqi Astika , Fitriliyani Indira , Bijaksana Untung
Published: June 2023

Termite flour is very promising as a raw material for snakehead feed to substitute fish meals. The good raw material and composition will produce quality artificial feed with a high level of water stability, preferred and safe for fish. The purpose of this study was to evaluate the quality of snakehead feed at various levels of substitution of fish meal with termites based on physical tests. The treatments given were the subtitution 0, 9, 6, 12% of fish meal with termite flour. The feed physical test results include water stability, homogeneity level, bouyancy, attractability, and storability. The results showed that the substitution of fish meal with termite flour was able to maintain water stability for more than 24 hours, the level of feed homogeneity was quite uniform in all treatments, the pungent aroma of feed preferred by snakehead was proven by the results of the feed allureness test which showed that the feed was eaten by snakehead in less than 5 seconds. The test results showed that the level of substitution of fish meal with termite flour with different levels resulted in feed with relatively the same quality in all treatments.
Attachment Phenomenon of Thick-shelled Squid Eggs on Selected Substrates: A Case in Barru Regency of South Sulawesi, Indonesia
Authors: Aras Muhammad , Hasmawati
Published: June 2023

Squids, when spawning, attach their eggs to the preferred substrate to develop well in the selected conditions. Experimental fishing research was conducted by direct observation of squid activities in the spawning area where squid eggs were attached to different substrates. The adult squid would first conduct an inspection and then attach their eggs to the selected substrate. The results showed that squid egg attachment time was conducted in the morning from 06.00 AM to 07.00 AM for 15 minutes at a duration of about 10-30 seconds. The number of egg capsules found in squid houses and various substrates in nature was 1,698 and 1,568 egg capsules. Squid eggs were found at a depth of 1-7 meters, with the most at a depth of 3 meters with 2,718 egg capsules.
Low Viral Load Testing in HIV Patients on Antiretroviral Therapy: Mitigation Measures in Ghana
Authors: Asumah Mubarick Nungbaso , Abubakari Abdulai , Mutaka M. Awell Olives , Donkor Doreen-Remember , Kumah Raphael Abolasom
Published: June 2023

The “Type of Article” of this paper is “Letter to the Editor”. This paper discuses about: “Low Viral Load Testing in HIV Patients on Antiretroviral Therapy: Mitigation Measures in Ghana”. No formal abstract is available. Readers are requested to read the full article.
Paradigm Shift in Agricultural/ Horticultural Production System through GAP to Fill the Gap between Potential Yield and Yield Obtained
Authors: Kumari Mamta
Published: June 2023

India is an agriculture-based country which is a very important and ancient enterprise of the whole world. It supplies food, fruit, vegetables, flowers to worship and decorate around the world. Apart from India there are any countries that are dependent on agriculture. It is the backbone of new industries like Sugar, Cotton etc. Krishi Vigyan Kendra, Sabour, Bhagalpur works in wide array of situations. It deals with sixteen blocks. Few blocks face flood in rainy seasons like Kharik, Naugachhia, Biharpur, Nathnagar, Sultanganj, Goradih and Gopalpur. Few of them have flood daught situations like Pirpainti, Kahalgaon, Sanhawla. Jagdishpur is the only block that always favoured that is hub of Katarni rice production. Katarni rice has GI Lag. Jardalu mango is very juicy tasty mango from Bhagapurl district also having GI tag. Due to poor management practices or there is big gaps/distances between yield and potential yield. Difference in potential yield and yield obtained is the ultimate loss of farmers. This is applied for all crops particularly for Horticultural crops. Because, horticultural crops fullfil the cash crunch of farmers. FAO has published training manual for good agricultural practices for fruit and vegetables crops. This type of manuals should be developed by different area for location specific crops. Bhagalpur has major area of mango, litchi, banana, pointed gourd, tomato. So, the manuals of good practices for these crops will be very productive to the farmers. To attain the potentiality of any crop farmers should follow the GAP (Good Agriculture of Practices) of that crop Naved Sabit et.al (2010) also and vacated for good practices of plant protection in different crops.
Efficacy of Insecticides against Major Insects of Tomato in Manipur
Authors: Salam Rhodesh , Devi H. Shila , Neog Pankaj , Imtinaro L. , Singh Y. Suraj , Devi H. Meronbala , Singh W. Ramdas
Published: June 2023

A field experiment was conducted to evaluate the efficacy of some insecticides viz., Emamectin benzoate 5% SG (11 ga.i./ha), imidacloprid 17.8% SL (22.5 g a.i/ha), Neem oil (3 ml/l), Beauveria bassiana (0.2 ml/l), fipronil 5% SC (50 g a.i/ha) against major pests of tomato (Lycopersicon esculentum Mill.). There were six treatments arranged in randomized block design with four replications. Fruit borer, whiteflies, aphids and leaf miner were found to be the major insect pests of tomato. Among the insecticide used, imidacloprid 17.8% SL was found to be the most effective for management of sucking pest viz., Whiteflies, Aphids, Thrips, Mealybugs, Jassids while emamectin benzoate was found more effective on tomato fruit borer. Beauveria bassiana was found least effective against all the insect pests.
Evaluating Artificial Intelligence Responses to Public Health Questions
Authors: Ayers John W. , Zhu Zechariah , Poliak Adam , Leas Eric C. , Dredze Mark , Hogarth Michael , Smith Davey M.
Published: June 2023

This cross-sectional study analyzes the quality of ChatGPT responses to public health questions.
Shear‐Responsive Drug Delivery Systems in Medical Devices: Focus on Thrombosis and Bleeding
Authors: Zeibi Shirejini Saeedreza , Carberry Josie , Alt Karen , Gregory Shaun D , Hagemeyer Christoph E
Published: June 2023

Cardiovascular disease is the leading cause of death worldwide. Blood‐contacting medical devices provide critical support for patients with severe respiratory and/or cardiac failure. High shear stress zones and non‐biocompatible circuit can increase the risk of thrombus formation in patients. These thrombi restrict blood flow through the circuits and travel to the lungs and brain, creating significant consequences. Antithrombotic drugs are used to lower this risk, but they also raise the incidence of bleeding problems. This article explores the delicate balance between thrombosis and bleeding in medical devices by examining platelet activation and thrombosis formation under shear stress. The feasibility of a shear‐responsive nanomedicine‐based drug delivery system has been explored as a potential approach for targeted administration of antithrombotic medications to lower systemic drug levels and reduce the bleeding risk. Furthermore, the lack of in vitro platforms to investigate the biological behavior of antithrombotic nanoparticles is impeding their clinical translation. As a result, microfluidic technology offers a platform for investigating nanoparticle behavior in vitro and linking it to their performance in vivo. Finally, the challenges and factors that affect the functionality, stability, and circulation time of liposomal drugs are investigated to improve their efficacy for targeted drug administration in medical devices.
Photocrosslinkable Zwitterionic Ligands for Perovskite Nanocrystals: Self‐Assembly and High‐Resolution Direct Patterning
Authors: Noh Sung Hoon , Jeong WonJo , Lee Kyeong Ho , Yang Han Sol , Suh Eui Hyun , Jung Jaemin , Park Seul Chan , Lee Dongwoon , Jung In Hwan , Jeong Yong Jin , Jang Jaeyoung
Published: June 2023

Perovskite nanocrystals (PNCs) are attractive photoactive materials in various optoelectronic devices including light‐emitting diodes, solar cells, and photodetectors. However, the weakly bound surface ligands on PNCs reduce colloidal stability and cause film formation and patterning difficulties, severely restricting their practical applications. Herein, a rationally designed photocrosslinkable zwitterionic (PZ) ligand is introduced to obtain directly patternable CsPbBr3 PNCs with enhanced colloidal stability, optical properties, and self‐assembly propensity. The PZ ligands strongly interact with the pre‐synthesized PNCs in solution, substantially replacing the original capping ligands and effectively passivating surface defects. This surface engineering induces strong electrostatic interactions between the PNCs, enabling the fabrication of densely packed CsPbBr3 PNC films. Furthermore, the methacrylate group of the PZ ligands serves as a bridge for active radical propagation in the ligand shells around the PNCs upon UV exposure. Accordingly, high‐resolution direct photopatterning can be achieved through ligand crosslinking, and the resulting PNC patterns (minimum line spacing of 4 µm) maintain optical stability for over 2 weeks. Therefore, this study demonstrates that a tailored ligand design strategy enables the simultaneous achievement of high colloidal stability, optical properties, photopatternability, and self‐assembly propensity and has considerable potential to be extended to other PNC materials.
Human Papilloma Virus DNA Detection in Clinical Samples Using Fluorogenic Probes Based on Oligonucleotide Gated Nanoporous Anodic Alumina Films
Authors: Hernández‐Montoto Andy , Aranda M. Nieves , Caballos Isabel , López‐Palacios Alba , Tormo‐Mas María Ángeles , Pemán Javier , Rodríguez Mireya Prieto , Picornell Carlos , Aznar Elena , Martínez‐Máñez Ramón
Published: June 2023

In this work, fluorogenic probes based on oligonucleotide capped nanoporous anodic alumina films are developed for specific and sensitive detection of human papilloma virus (HPV) DNA. The probe consists of anodic alumina nanoporous films loaded with the fluorophore rhodamine B (RhB) and capped with oligonucleotides bearing specific base sequences complementary to genetic material of different high‐risk (hr) HPV types. Synthesis protocol is optimized for scale up production of sensors with high reproducibility. The sensors' surfaces are characterized by scanning electron microscopy (HR‐FESEM) and atomic force microscopy (AFM) and their atomic composition is determined by energy dispersive X‐ray spectroscopy (EDXS). Oligonucleotide molecules onto nanoporous films block the pores and avoid diffusion of RhB to the liquid phase. Pore opening is produced when specific DNA of HPV is present in the medium, resulting in RhB delivery, that is detected by fluorescence measurements. The sensing assay is optimized for reliable fluorescence signal reading. Nine different sensors are synthesized for specific detection of 14 different hr‐HPV types in clinical samples with very high sensitivity (100%) and high selectivity (93–100%), allowing rapid screening of virus infections with very high negative predictive values (100%).
Cascaded Nanozyme with In Situ Enhanced Photothermal Capacity for Tumor‐Specific and Self‐Replenishing Cancer Therapy
Authors: Cai Xiaoli , Liu Renyu , Yan Hongye , Jiao Lei , Sha Meng , Chen Yifeng , Rong Shuang , Liu Zhengzheng , Deng Liu , Shen Liangfang , Zhu Chengzhou
Published: June 2023

Reactive oxygen species (ROS)‐involved tumor therapeutic strategy, chemodynamic therapy (CDT), has attracted extensive research interest in the scientific community. However, the therapeutic effect of CDT is insufficient and unsustainable owing to the limited endogenous H2O2 level in the tumor microenvironment. Here, peroxidase (POD)‐like RuTe2 nanozyme with the immobilization of glucose oxidase (GOx) and allochroic 3,3′,5,5′‐tetramethylbenzidine (TMB) molecule have been synthesized to construct RuTe2‐GOx‐TMB nanoreactors (RGT NRs) as cascade reaction systems for tumor‐specific and self‐replenishing cancer therapy. GOx in sequential nanocatalysts can effectively deplete glucose in tumor cells. Meanwhile, a sustainable supply of H2O2 for subsequent Fenton‐like reactions catalyzed by RuTe2 nanozyme is achieved in response to the mild acidic tumor microenvironment. Through this cascade reaction, highly toxic hydroxyl radicals (·OH) are produced, which can further oxidize TMB to trigger tumor‐specific “turn‐on” photothermal therapy (PTT). In addition, PTT and massive ROS can stimulate the tumor immune microenvironment and activate the systematic anti‐tumor immune responses, exerting a notable effect on hindering tumor recurrence and metastasis. This study paves a promising paradigm for synergistic starvation therapy, PTT, and CDT cancer therapy with high efficiency.
N‐Acetyl‐l‐cysteine‐Derived Carbonized Polymer Dots with ROS Scavenging via Keap1‐Nrf2 Pathway Regulate Alveolar Bone Homeostasis in Periodontitis
Authors: Liu Xinchan , Hou Yubo , Yang Mingxi , Xin Xirui , Deng Yu , Fu Ruobing , Xiang Xingchen , Cao Niuben , Liu Xiaomeng , Yu Weixian , Yang Bai , Zhou Yanmin
Published: June 2023

Periodontitis is a type of chronic inflammatory oral disease characterized by the destruction of periodontal connective tissue and progressive alveolar bone resorption. As oxidative stress is the key cause of periodontitis in the early periodontal microenvironment, antioxidative therapy has been considered a viable treatment for periodontitis. However, more stable and effective reactive oxygen species (ROS)‐scavenging nanomedicines are still highly needed due to the instability of traditional antioxidants. Herein, a new type of N‐acetyl‐l‐cysteine (NAC)‐derived red fluorescent carbonized polymer dots (CPDs) has been synthesized with excellent biocompatibility, which can serve as an extracellular antioxidant to scavenge ROS effectively. Moreover, NAC‐CPDs can promote osteogenic differentiation in human periodontal ligament cells (hPDLCs) under H2O2 stimulation. In addition, NAC‐CPDs are capable of targeted accumulation in alveolar bone in vivo, reducing the level of alveolar bone resorption in periodontitis mice, as well as performing fluorescence imaging in vitro and in vivo. In terms of mechanism, NAC‐CPDs may regulate redox homeostasis and promote bone formation in the periodontitis microenvironment by modulating the kelch‐like ECH‐associated protein l (Keap1)/nuclear factor erythroid 2‐related factor 2 (Nrf2) pathway. This study provides a new strategy for the application of CPDs theranostic nanoplatform for periodontitis.
A Monolayer High‐Entropy Layered Hydroxide Frame for Efficient Oxygen Evolution Reaction
Authors: Ding Yiran , Wang Zhouyang , Liang Zijia , Sun Xueping , Sun Zihang , Zhao Yuanxin , Liu Junlin , Wang Chenyang , Zeng Ziyue , Fu Lei , Zeng Mengqi , Tang Lin
Published: June 2023

High‐entropy materials with tailored geometric and elemental compositions provide a guideline for designing advanced electrocatalysts. Layered double hydroxides (LDHs) are the most efficient oxygen evolution reaction (OER) catalyst. However, due to the huge difference in ionic solubility product, an extremely strong alkali environment is necessary to prepare high‐entropy layered hydroxides (HELHs), which results in an uncontrollable structure, poor stability, and scarce active sites. Here, a universal synthesis of monolayer HELH frame in a mild environment is presented, regardless of the solubility product limit. Mild reaction conditions allow this study to precisely control the fine structure and elemental composition of the final product. Consequently, the surface area of the HELHs is up to 380.5 m2 g−1. The current density of 100 mA cm−2 is achieved in 1 m KOH at an overpotential of 259 mV, and, after 1000 h operation at the current density of 20 mA cm−2, the catalytic performance shows no obvious deterioration. The high‐entropy engineering and fine nanostructure control open opportunities to solve the problems of low intrinsic activity, very few active sites, instability, and low conductance during OER for LDH catalysts.
A T Cell‐Engaging Tumor Organoid Platform for Pancreatic Cancer Immunotherapy
Authors: Zhou Zhuolong , Van der Jeught Kevin , Li Yujing , Sharma Samantha , Yu Tao , Moulana Ishara , Liu Sheng , Wan Jun , Territo Paul R. , Opyrchal Mateusz , Zhang Xinna , Wan Guohui , Lu Xiongbin
Published: June 2023

Pancreatic ductal adenocarcinoma (PDA) is a clinically challenging disease with limited treatment options. Despite a small percentage of cases with defective mismatch DNA repair (dMMR), PDA is included in the most immune‐resistant cancer types that are poorly responsive to immune checkpoint blockade (ICB) therapy. To facilitate drug discovery combating this immunosuppressive tumor type, a high‐throughput drug screen platform is established with the newly developed T cell‐incorporated pancreatic tumor organoid model. Tumor‐specific T cells are included in the pancreatic tumor organoids by two‐step cell packaging, fully recapitulating immune infiltration in the immunosuppressive tumor microenvironment (TME). The organoids are generated with key components in the original tumor, including epithelial, vascular endothelial, fibroblast and macrophage cells, and then packaged with T cells into their outside layer mimicking a physical barrier and enabling T cell infiltration and cytotoxicity studies. In the PDA organoid‐based screen, epigenetic inhibitors ITF2357 and I‐BET151 are identified, which in combination with anti‐PD‐1 based therapy show considerably greater anti‐tumor effect. The combinatorial treatment turns the TME from immunosuppressive to immunoactive, up‐regulates the MHC‐I antigen processing and presentation, and enhances the effector T cell activity. The standardized PDA organoid model has shown great promise to accelerate drug discovery for the immunosuppressive cancer.
Zirabia cylindrica comb. nov. provides evidence of Doyleales in the Jurassic
Authors: Elgorriaga Andres , Atkinson Brian A.
Published: June 2023

Premise

In recent years, Doyleales have played an important role in the discussion and exploration of seed plant relationships and the origin of angiosperms. This order comprises a diversity of recently described genera with cupule‐bearing compound ovulate cones recovered from Early Cretaceous deposits in North America and Asia. Their relatively late appearance in the fossil record, stratigraphically near the appearance of angiosperms in the Early Cretaceous, has been noteworthy. Here, we report a new genus of Doyleales, Zirabia gen. nov. from the Early Jurassic of Iran, that was originally described as the ginkgophyte Karkenia.

Methods

We reinvestigated material previously assigned to Karkenia cylindrica from the Lower Jurassic of the Zirab locality, Alborz Mountains, northern Iran.

Results

The studied specimen features a main axis bearing helically to irregularly arranged bract‐cupule complexes, each composed by a long laminar bract subtending and sheathing a cupule stalk that bears a single‐seeded cupule with a dorsal protrusion. The morphological features of this taxon do not conform with those of Karkenia, and suggest affinities with Doyleales rather than Ginkgoales. Within Doyleales, this fossil has a unique combination of characters indicating that it is a new genus within the order; thus, a new combination is erected, Zirabia cylindrica.

Conclusions

Our results indicate that Doyleales is significantly older than previously thought, with their stratigraphic range now extending from the Lower Jurassic to the Cretaceous. The Early Jurassic occurrence of Doyleales provides important data on the emergence of seed‐enclosing structures seen in seed plants throughout the Mesozoic.
Experiences of police‐related stress among a U.S. national cohort of gay and bisexual men
Authors: Bacchus Erinn C. , D'Angelo Alexa B. , Grov Christian
Published: June 2023

Marginalized groups (including people of Color and sexual minorities) have been over‐policed and specifically targeted based on their race/ethnicity and identity. The deleterious effects of over‐policing marginalized groups include overrepresentation in the carceral system, experiencing higher rates of violence from police, and extend to affect mental health and stress levels. This study examines police‐related stress among a U.S. national cohort of gay and bisexual men (collected in late 2020 and early 2021) and its association with race/ethnicity, age, human immunodeficiency virus (HIV) status, income, and other characteristics of interest. Our results show that the odds of reporting extreme police‐related stress were 2.7 (95% confidence interval [CI] [2.08, 3.41]) times higher for Black individuals than for their White counterparts. Odds were also significantly greater for those who have experienced race‐based (odds ratio [OR] = 2.26, 95% CI [1.81–2.82] or identity‐based discrimination (OR = 2.05, 95% CI [1.66, 2.54]). Our findings demonstrate variation in police‐related stress among a cohort of gay and bisexual men; with men of Color and low‐income men among the most affected by police‐related stress. For this population, police‐related stress should be considered for its potential deleterious effect on HIV vulnerability and reporting violent crimes to police (including intimate partner violence and hate crimes).
Efficient Cross‐Dehydrogenative Coupling (CDC) Enabled by Cu‐PMo12 towards the Synthesis of Pyrimidinyl Carbamates at Room Temperature
Authors: Gaware Sujeet , Chatterjee Rana , Kotkondawar Abhay Vijay , Dandela Rambabu
Published: June 2023

A novel and efficient approach has been developed for the direct synthesis of pyrimidinyl dimethylcarbamate using Cu‐PMo12 complex. Basically, Cu‐PMA catalyst successfully enabled the cross‐dehydrogenative coupling (CDC) reaction between N‐benzoyl cytosine and formamides in the presence of tert‐butyl hydroperoxide and triethyl amine. Herein, Cu(I/II) catalytic system facilitated the oxidative coupling of the carbamide function, generating a new C−O bond and has been identified as more efficient compared to other commercially available Cu (I) or Cu (II) salts. Furthermore, the characterization of the catalyst was performed by XPS, SEM and EDX analysis. The present method also demonstrates a simple procedure with least catalyst loading, a wide variety of substrates with excellent functional group compatibility, high yields, ambient conditions, and operational simplicity.
Preparedness of China's health care system to provide access to a disease‐modifying Alzheimer's treatment
Authors: Mattke Soeren , Loh Wei Kok , Yuen Kah‐Hung , Yoong Joanne
Published: June 2023

INTRODUCTION

Although the majority of patients with Alzheimer's disease (AD) reside in low‐and middle‐income countries, little is known of the infrastructure in these countries for delivering emerging disease‐modifying treatments.

METHODS

We analyze the preparedness of China, the world's most populous middle‐income country, using desk research, expert interviews and a simulation model.

RESULTS

Our findings suggest that China's health care system is ill‐prepared to provide timely access to Alzheimer's treatment. The current pathway, in which patients seek evaluation in hospital‐based memory clinics without a prior assessment in primary care, would overwhelm existing capacity. Even with triage using a brief cognitive assessment and a blood test for the AD pathology, predicted wait times would remain over 2 years for decades, largely due to limited capacity for confirmatory biomarker testing despite adequate specialist capacity.

DISCUSSION

Closing this gap will require the introduction of high‐performing blood tests, greater reliance on cerebrospinal fluid (CSF) testing, and expansion of positron emission tomography (PET) capacity.
Dual Atom Catalysts for Energy and Environmental Applications
Authors: Pu Tiancheng , Ding Jiaqi , Zhang Fanxing , Wang Ke , Cao Ning , Hensen Emiel J. M. , Xie Pengfei
Published: June 2023

The pursuit of high metal utilization in heterogeneous catalysis has triggered the burgeoning interest of various atomically dispersed catalysts. Our aim in this review is to assess key recent findings in the synthesis, characterization, structure‐property relationship and computational studies of dual‐atom catalysts (DACs), which cover the full spectrum of applications in thermocatalysis, electrocatalysis and photocatalysis. In particular, combination of qualitative and quantitative characterization with cooperation with DFT insights, synergies and superiorities of DACs compare to counterparts, high‐throughput catalyst exploration and screening with machine‐learning algorithms are highlighted. Undoubtably, it would be wise to expect more fascinating developments in the field of DACs as tunable catalysts.
Total Synthesis of Illisimonin A and Merrilactone A
Authors: Gong Xu , Huang Juan , Sun Xiangrui , Chen Ziling , Yang Ming
Published: June 2023

Illicium sesquiterpenes are a large family of biologically active secondary metabolites isolated from Illicium species of plants and are well‐known for their activity of neurite outgrowth in cultured neurons. Herein, we propose a comprehensive biosynthetic pathway for illicium sesquiterpenes and report a synthetic route to illisimonin A and merrilactone A based on it. We think that the carbon scaffolds of most of the illicium sesquiterpenes could be synthesized from a dicarbonyl derivative of allo‐cedrane through retro‐Dieckmann condensation, oxidative cleavage and aldol reaction at suitable oxidation states in Nature. The common intermediate for illisimonin A and merrilactone A similar to the dicarbonyl derivative of allo‐cedrane was assembled with up to 82 % ee by an asymmetric intramolecular desymmetrizing reductive Heck reaction by the use of a new type of chiral phosphine ligand. The syntheses of illisimonin A and merrilactone A supported the key transformations of the proposed biosynthetic pathway.
Cobalt‐Catalyzed Regiodivergent Ring‐Opening Dihydroboration of Arylidenecyclopropanes to Access Skipped Diboronates
Authors: Tan Boon Beng , Hu Ming , Ge Shaozhong
Published: June 2023

Ligand‐controlled regiodivergent cobalt‐catalyzed ring‐opening dihydroboration of arylidenecyclopropanes is developed to access synthetically versatile skipped diboronates with catalysts generated in situ from Co(acac)2 and dpephos or xantphos. A variety of arylidenecyclopropanes reacted with pinacolborane (HBpin) to form the corresponding 1,3‐ or 1,4‐diboronates in high isolated yields and with high regioselectivity. Skipped diboronate products from these reactions can undergo various transformations to allow selective installation of two different functional groups along alkyl chains. Mechanistic studies suggest that these reactions combine cobalt‐catalyzed ring‐opening hydroboration of arylidenecyclopropanes and hydroboration of homoallylic or allylic boronate intermediates.