bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of the Controlled Dump of Fez City (Morocco): Evaluation of Metallic Trace Elements Contamination in the Sediments
Authors: Ahouach Youssra , Baali Abdennasser , Boushaba Abdellah , Hakam Oualid , Azennoud Khalil , Lyazidi Aziza , Benmessaoud Safaa , Assouguem Amine , Kara Mohammed , Alsaigh Mona Abdullah , Al-Mohaimeed Amal M. , Chen Tse-Wei
Published: March 2023

In order to qualify and quantify the impact of sediment contamination in hydric settings by metallic trace elements (MTE) emanating from the controlled dump of Fez city (northern Morocco), leachate and sediment sample analyses were carried out. The leachates collected from the 24 sites are characterised by a pH between 6.91 and 8, a COD varying between 430.7 and 7962 mg/L, an NTK content up to 1955 mg/L, with an average of 1514 mg/L, and a nitrate concentration reaching 46 mg/L in some samples, which exceeds the standards for discharges into the natural environment. The chromium content emanating mainly from household waste varies between 1.69 and 4.90 mg/L. The MTE content (As, Cd, Co, Cr, Cu, Ni, Pb, Zn and Fe) of the different leachates varies from one basin to another. The sediments downstream of the dump along the sampling profile show pH values between 7.34 and 8.21 (compared to 7.96–8.82 for the reference samples), and electrical conductivity values fluctuate between 1.21 ms/cm and 5.37 ms/cm for the contaminated sediments (compared to 0.8 ms/cm for the reference sediment). The analysis of metallic trace elements in the sediments by ICP-AES shows that their content varies slightly from one sampling point to another. Furthermore, they do not vary considerably from the surface (0 cm) to the depth (20 cm). The average values of metallic element concentrations are 45.83 ± 2.14 mg/Kg for Cu, 4.40 ± 0.07 mg/Kg for Cd, 43.76 ± 3.40 mg/Kg for Cr, 72.99 ± 1.85 mg/Kg for Ni, 21.71 ± 6.55 mg/Kg for Pb and 102.02 ± 7.28 mg/kg for Zn. In effect, the negative environmental impact of Fez controlled dumping site is ostensibly underlined both by (i) the pollution load index values, which indicate a strong and progressive deterioration along the thalweg, and (ii) the statistical analysis (PCA), which reveals a common origin of the deduced pollutants through the strong correlation between the majority of the analysed elements.
Effects of Probiotics on the Water Quality, Growth Performance, Immunity, Digestion, and Intestinal Flora of Giant Freshwater Prawn (Macrobrachium rosenbergii) in the Biofloc Culture System
Authors: Qiu Zongsheng , Xu Qiyou , Li Shenghao , Zheng Dakua , Zhang Rongfei , Zhao Jianhua , Wang Ting
Published: March 2023

In order to explore the effects of probiotics on the water quality, growth performance, nonspecific immunity, digestion, and intestinal flora of Macrobrachium rosenbergii in the biofloc culture system, three groups (six replicates in each group) were set up and divided into no bacteria (control group, Con), Bacillus subtilis (BS), and effective microorganisms (EM) in the current experiment. After dissolution of the water, the carbon source (glucose) was evenly sprayed in the aquaculture tank to construct a biofloc with a C/N of 15. A total of 1260 giant freshwater prawn (Macrobrachium rosenbergii) with an initial body weight of (2.09 ± 0.03) g were randomly assigned to 18 tanks (70 per tank). BS group and EM group significantly reduced total nitrogen concentration. Both BS and EM groups significantly increased final mean body weight, weight gain, and specific growth rate, but significantly decreased feed conversion rate of Macrobrachium rosenbergii. BS group significantly increased plasma superoxide dismutase, lysozyme, and acid phosphatase contents, but significantly decreased plasma malonaldehyde content. EM group significantly increased serum acid phosphatase content and intestinal trypsin activity but significantly decreased the Chao and ACE index of species richness. BS group and EM group significantly decreased the abundance of Chloroflexi and Verrucomicrobiota. BS group significantly increased the abundance of Bacillus. Overall, adding probiotics affected water quality, Macrobrachium rosenbergii performance, and microbial community. The results showed that Bacillus subtilis is a good biofloc probiotic additive.
Tax for unmarried and childless persons (bachelor tax) in a historical perspective and possibilities for its establishment in modern times
Authors: Tsvetanova Marina
Published: March 2023

The article examines the establishment of the tax for unmarried and childless persons (bachelor tax) and its historical development during the four Bulgarian constitutions. The problems of the legislative process are being explored, as well as those of the compliance of the bachelor tax with the constitutional and tax provisions, with the principles and objectives of taxation, the fundamental rights and constitutional principles. The article discusses the possibility for the establishment of this tax in modern times.
Actitud del docente en la educación inclusiva
Authors: Quispe Choque María Elena , Concha Abarca John , Quispe Choque Marcelina
Published: March 2023

En los últimos años, la inclusión ha tomado gran fuerza en la educación, pero al mismo se ha convertido en un desafío, debido a la baja formación y comprensión sobre este tema en las instituciones y docentes; más aún en los educadores que por medio de su enseñanza y actitudes que le brinda al estudiante para desarrollar el objetivo educativo. El objetivo del artículo fue analizar la actitud del docente en la educación inclusiva. En referencia a la metodología, esta se realizó mediante un análisis de revisión sistemática, consultando revistas científicas educativas sobre la temática abordada y recolectar información relevante para la investigación, considerando 50 artículos. Las conclusiones manifiestan, que la educación incluye una fuerte conexión con el desarrollo y la práctica de valores culturales, donde requiere que la mayor parte de la escuela se base en recursos adecuados. Además, la actitud del docente ha sido reconocida como un indicador clave de la plena participación de niños y jóvenes.
Aplicación de la evaluación formativa en estudiantes de educación superior
Authors: Sanchez-Peña Hugo , Ipushima-Ochavano Doylith , Solís-Trujillo Beymar Pedro
Published: March 2023

Cuando se aborda el problema relacionado a la forma de evaluar a los estudiantes de educación superior, se puede decir que existen docentes que siguen aplicando la evaluación tradicional, y no una evaluación formativa. El artículo tiene como objetivo analizar la evaluación formativa en estudiantes de educación superior. El estudio se realizó bajo el enfoque cualitativo, de análisis documental de estudios académicos de naturaleza científica referentes a la evaluación formativa en la educación superior; para ello, se tomó en cuenta el método PRISMA. Por lo tanto, se concluye que, la evaluación formativa contribuye con el logro de competencias básicas y profesionales en los estudiantes del nivel superior. Además, que la aplicación de la evaluación formativa en estudiantes de Educación Superior tiene una influencia positiva porque le permite lograr competencias, autorregular su aprendizaje, mejorar sus desempeños y desarrollar sus habilidades como futuro profesional.
Entre adaptation et résistance : requalifer les populations russes dans les pays baltes
Authors: Bonnard Pascal
Published: March 2023

Les définitions concurrentes de la catégorie « russe » promues par les représentants des communautés russes des pays baltes et par les autorités de ces pays font l'objet de cette étude. La politique, dans un premier temps indifférenciée menée à l'égard des populations non titulaires, a permis aux dirigeants russes de mettre en avant une catégorie russe élargie, fondée sur la pratique linguistique. Soucieuses de fragmenter cet ensemble russophone, les autorités locales ont utilisé divers mécanismes, allant d'une politique d'assimilation à une grille de lecture selon la date d'installation puis l'origine ethnique. Les porte-parole russes se sont adaptés de façon différenciée à ces nouvelles qualifications, essayant de les reformuler, d'y résister et choisissant, parfois, de se les approprier.
Comparison of bleaching effect on discolored teeth by different beverages: an in vitro study
Authors: Nguyen Thi Thuy Duong , Bui Huy Chuong , Nguyen Thanh Tung
Published: March 2023

Background: Tooth bleaching is an effective method to remove both endogenous and exogenous stains. This study aims to evaluate and compare the bleaching efficacy of tea, coffee and cola stains on teeth. Materials and Methods: 30 bovine tooth samples were divided into three groups: tea, coffee and cola (n = 10/group). Staining was obtained by soaking the tooth samples for 3 weeks in each drinks. Before bleaching, tooth samples were polished with fine pumice powder and slow-speed handpiece for 10 seconds, speed of 2500 rpm. The bleaching process was performed with 10% carbamide peroxide for 14 days, 8 hours/day. The effectiveness of the bleaching process is evaluated through the change in the brightness (L*), saturation (a*, b*) values and the total color change (DE*) of the CIELAB system with Crystaleye spectrocolorimeter. Results: After bleaching process, all three stained groups showed the color changes in the following direction: increase L*, decrease a*, decrease b*. The
polishing phase could remove part of the staining and the whitening phase achieved the fastest bleaching effect after 1 week. The tea group achieved a greater color change than the cola group during all phases and greater than the coffee group at the polishing phase (p<0.05). Conclusions: The polishing phase is effective in removing the exogenous stains on teeth due to beverage consumption. The bleaching efficacy between the teeth stained with tea, coffee and cola is different, in which the teeth stained with tea have a higher whitening effect.
Key words: tea, coffee, cola, extrinsic stain, bleaching
Clinical, endoscopic features and histopathology classification of gastrointestinal polyps
Authors: Nguyen Van Mao , Tran Nam Dong , Phan Cong Bao
Published: March 2023

Background: Gastrointestinal polyps are common, proliferative or neoplastic mucosal lesions protruding into the lumen of the digestive tract. Gastrointestinal polyps are considered to be precursors to cancer development. Therefore, the cancer potential can be reduced to a great extent by early detection and removal of polyps. Clinical symptoms of the disease are often poor and unclear so early detection and diagnosis are definitely based on endoscopy and especially histopathology to classify and evaluate benign or malignant potential of polyps. Objectives: 1. To describe some clinical and endoscopic features of gastrointestinal polyps. 2. To diagnose and classify histopathological types of gastrointestinal polyps, evaluate the correlation of some endoscopic features and histopathology. Materials and Methods: Cross-sectional research on 77 patients diagnosed by Endoscopy and histopathology at the Hospital of Hue University of Medicine and Pharmacy from 02.2020 to 01.2022. Results: Gastrointestinal polyps were common in patients ≥ 60 years (49.4%), the ratio of male/female was 1.4.
Common reasons for hospital admission: abdominal pain (33.8%), hematochezia (31.2%). Common symptoms: abdominal pain 62.5%, hematochezia 35.1%. The majority of polyps were located in the colorectal at a rate of 89.6%. Number of polyps per patient: Single polyp (66.2%), multiple polyps (33.8%), no polyposis case. Polyps usually have the characteristics: peduncle (66.2%), clear boundary (80.5%), smooth surface (71.4%). Size of polyps: < 1 cm (74%), > 2 cm were very rare, accounting for 2.6%. Histopathological results showed that adenoma and hyperplasia polyps accounted for the highest proportion, respectively 46.8% and 40.3%. Level of dysplasia: no dysplasia (48%), low grade dysplasia (37.7%) and high grade dysplasia (14.3%). Adenocarcinoma polyps accounted for 5.2% (4 patients), of which 2 patients had carcinoma in situ and 2 patients with invasive adenocarcinoma. There was no statistically significant difference between the endoscopic features and the histopathological results. Conclusion: Endoscopy is a common and effective means to detect gastrointestinal
polyps. However, the nature of these polyps has yet to be confirmed, especially the high risk ones of malignancy. For this reason, a biopsy or excision of the polyp is necessary for histopathology
Key words: Gastrointestinal polyps, endoscopy, histopathology.
Role of computed tomography to preoperative tumor localization in colon cancer
Authors: Do Thi Y , Nguyen Huu Tri
Published: March 2023

Objectives: To evaluate the role of computed tomography to preoperative tumor localization compared to optical colonoscopy in colon cancer. Methods: A prospective study on 49 colon cancer patients confirmed by postoperative pathology of colon adenocarcinoma who underwent colectomy at Hue University of Medicine and Pharmacy Hospital from April 2019 to August 2020. The colon was divided into four segments with the operative reports used as the standard. Results: 49 colon cancers patients had 51 tumors. Computed tomography localization was 92.2% accurate. Colonoscopic localization was only 76.5% accurate. The computed tomography inaccurate tumor localization was 7.8% vs 23.5% in colonoscopy (p<0.05). Colonoscopic inaccuracy was high in the the transverse colon (85.7%) and the descending colon (20.0%). Conclusions: Preoperative
computed tomography is more accurate than colonoscopy in the localization of colon cancers.
Key words: computed tomography, tumor localization, colonoscopy, colon cancer.
Evaluation of CTP - creatinine for predicting prognosis of cirrhosis patients with acute variceal bleeding
Authors: Nguyen Van Loc , Phan Trung Nam
Published: March 2023

Background: Variceal bleeding is a severe complicaton of portal hypertension due to cirrhosis with high rate of motality. This study to evaluate the accuracy CTP - Creatinine score for predicting early rebleeding and mortality and in first 6 weeks in cirrhosis patient with acute variceal bleeding. Methods: Prospective study in 118 cirrhosis patients presenting with acute variceal bleeding were hospitalized and diagnosed by upper GI endoscopy. Exclusion criteria were patients with chronic kidney diseases. Results: The mean values of the CTP - Crea I and CTP - Crea II score are 9.03 ± 2.73 and 8.97 ± 2.65, respectively. The CTP - Crea I score was valuable in predicting outcomes early rebleeding with AUC = 0.788, early death with AUC = 0.860 and
within the first 6 weeks: rebleeding with AUC = 0.672 and mortality AUC = 0.818. The CTP - Crea II score has predictive value for outcomes early rebleeding with AUC = 0.771, early death with AUC = 0.859 and mortality within the first 6 weeks with AUC = 0.805. Conclusions: CTP - Creatinine scores have good value in predicting outcome in cirrhosis patients with acute variceal bleeding. Can be applied to evaluate and stratify those cirrhosis patients in clinical practice in Vietnam.
Key words: variceal bleeding, CTP, Creatinine.
Evaluation of quality of life in patients with ureteral double J stent
Authors: Le Dinh Dam , Nguyen Tran Hanh Quyen , Nguyen Xuan My , Nguyen Nhat Minh , Vo Minh Nhat , Nguyen Khoa Hung , Le Dinh Khanh
Published: March 2023

Purpose: To evaluate quality of life and related factors in patients with ureteral stents. Materials and Methods: The clinical description study was performed on 83 patients with ureteral DJ stent placement follow-up of 1 month at the Department of Urology, Hue University of Medicine and Pharmacy Hospital from June, 2019 to April, 2020. Results: Average age: 49.55 ± 12.19 years. Female/male 1.13. Stone-free rate: 49.4%. Average point of the quality of life: 0.833 ± 0.137. The factors related to quality of life of patients with JJ stent: age, sex, types of operations. Conclusion: the majority of the patients with ureteral double j stent were well tolerated, pain and irritative voiding symptoms have a significant impact on health related quality of life
Key words: JJ stent, quality of life, EQ-5D-5L, USSQ
Obstrucción de la Vía Lagrimal en el Período Neonatal: Diagnósticos Diferenciales - Revisión Bibliográfica del Tema
Authors: Huang Shih Chyong-Yng , Argüello Cruz Leslie , Mendiola Solari Fernando , Hidalgo Mora Oscar
Published: March 2023

Objetivo: describir diferentes diagnósticos diferenciales de la obstrucción de la vía lagrimalMateriales y Métodos: revisión bibliográfica y análisis de artículos encontrados mediante elbuscador PubMed asociados al temaResultados: se hizo un análisis total de 23 artículos sobre los temas epífora, disgenesia del drenajelagrimal, dacrioestenosis, dacriocistocele congénito y malformaciones craneofaciales asociadas aobstrucción de la vía lagrimal. Se hizo revisión de la epidemiología, presentación clínica,diagnóstico, manejo y complicaciones de cada patología.Conclusiones: existen diversos diagnósticos diferenciales de la obstrucción de vía lagrimal que sedeben conocer y diagnosticar de manera temprana para poder decidir el mejor tratamiento, ya seael conservador o el sondaje lagrimal.
Enfermedad de Mondor y su presentación en pene: Revisión bibliográfica
Authors: Hernández Quirós Thania
Published: March 2023

Las vasculopatías son bastante frecuentes en la población en especial en el género femenino en gran parte por un componente hormonal, sin embargo, en esta revisión bibliográfica nos enfocaremos en un tipo de tromboflebitis superficial que aflige exclusivamente a los varones.

La enfermedad de Mondor del pene afecta específicamente a la vena dorsal del pene en hombres jóvenes sexualmente activos en la mayor parte de los casos. Presenta un curso casi siempre benigno y de autorresolución, por lo que su manejo suele ser conservador.
Sistem Informasi Pengaduan Pada Komite Olahraga Nasional Indonesia Provinsi Bali Berbasis Web
Authors: Alfiani  , Agustino Dedy Panji , Vony Purnama I Gusti Agung
Published: March 2023

Dengan kemajuan teknologi saat ini, Komite Olahraga Nasional Indonesia Provinsi Bali diharapkan semakin berkembang dalam pelayanannya. Pada Komite Olahraga Nasional Indonesia  Provinsi Bali tidak menyediakan pengaduan, sehingga jika terdapat kendala pada fasilitas ataupun pelayanan yang dialami masyarakat saat berkunjung, tidak langsung ditangani. Penilitian ini dilakukan untuk membangun sistem yang bertujuan untuk manajemen pengaduan pada Komite Olahraga Nasional Indonesia (KONI) Provinsi Bali, sistem ini menyediakan media komunikasi antara masyarakat, atlet dan staf kantor komite dalam penginformasian aduan kendala fasilitas atau pelayanan yang dialami agar penangan dapat dilakukan lebih cepat. waterfall merupakan metode yang digunakan pada penelitian ini untuk pengembangan website. Ada lima tahap yang harus dilakukan dalam proses pelaksanaanya yaitu, analisis, perancangan, implementasi, maintenance, dan pengujian. Cara untuk mendapatkan hasil yang optimal adalah dengan melakukan pengujian secara menyeluruh antarmuka sistem website menggunakan black box testing dengan tujuan untuk mengetahui apakah fungsi-fungsi pada website sudah berjalan sesuai dengan fungsinya.. Hasil akhir penelitian dengan pengujian blackbox dapat disimpulkan bahwa website pengaduan komite olahraga nasional dapat digunakan oleh masyarakat sebagai tempat pengaduan menganai fasilitas dan pelayanan pada KONI Provinsi bali.
Hubungan Pola Asuh Orang Tua dengan Tingkat Kematangan Emosi Siswa
Authors: Desvita Dola , Fitria Linda , Sefriani Rini
Published: March 2023

Emotional maturity is a condition where a person is able to control, control and channel his emotions based on the situation and conditions that occur, so that he has a good level of emotional stability in solving a problem that occurs. The factors that can affect emotional maturity here are one of them influenced by parenting patterns, where parenting here is how to educate, maintain, nurture and guide their children towards the maturation process. The purpose of this study was to determine the relationship between parenting patterns with the level of emotional maturity of students. This study examines the relationship between parenting patterns with the level of emotional maturity of students, where the method used in this study is quantitative correlation. The population in this study amounted to 210 people who were registered with a sample of 138 students. The sampling technique used is purposive sampling. The instrument in this study was a questionnaire with a likert scale. Data analysis was performed using statistical programs on IBM Statistical 20 computers and Microsoft Excel. Based on the results of data processing, the rcount value is 0.450 with an rtable value of 0.165, the rcount value is greater than the rtable value 0.450> 0.1656, it can be concluded that there is a positive and significant relationship between the relationship between parenting patterns and the level of emotional maturity of students.
Validitas Perancangan Game Edukasi Berbasis Android pada Mata Pelajaran Informatika
Authors: Radyuli Popi , Menrisal  , Mukziza Liling Nurul
Published: March 2023

This study aims to describe the validity of Android-based educational game learning media in the Informatics subject at SMK Negeri 9 Padang. This research is a Research and Development study conducted in class X at SMK Negeri 9 Padang. The test subjects in this study were class X students majoring in Culinary and Hospitality. The instrument used is a media validation sheet which will be validated by material experts, media experts and linguists. The results of the assessment of the three validators obtained a validity test of 88.81%, so that the validity level can be interpreted as very valid to use. In conclusion, based on the assessment along with expert input as well as the results of field trials of Android-based educational games, the feasibility, excellence, and can be used in the learning process in Informatics class X SMK N 9 Padang
PSYCHOEMOTIONAL STATUS OF WOMEN WITH INFERTILITY AFTER COVID 19 DISEASE
Authors: BOYCHUK O.G. , GOLOVCHAK I.S.
Published: March 2023

The 2019 coronavirus pandemic has affected the mental health of people around the world.

Purpose: to study the psycho-emotional status of women with infertility after Covid 19 disease.

Materials and Methods. The comprehensive study included 150 patients in ART programs. The main group consisted of 100 patients with infertility of reproductive age who had Covid 19 and were divided into 2 subgroups. The first subgroup consisted of 70 women in whom ART treatment was not effective, and the second subgroup consisted of 30 patients in whom ART treatment was effective. The comparison group consisted of 50 patients who did not have Covid 19. The FertiQoL questionnaire and the method of differential diagnosis of depressive states by V. Zung were used to assess the psychoemotional status.

Results. Reproductive problems affect the quality of life of women with Covid 19 and cause psychological disorders. More than a third (35.7%) of women whose ART treatment was ineffective assess their health as poor or very poor, and more than half (52.8%) are dissatisfied with their quality of life. The emotional sphere suffered the most from fertility problems, with an average score of 45.3±2.2. The scores on the “mental and physical health” and “social sphere” scales were also lower. Although the patients rated the quality of infertility treatment quite highly, its tolerability was worse in this group of women. At the same time, the condition of half of the women was assessed as subdepressive or masked depression (54.3%), and depression was diagnosed in 14.3%.

Conclusion. Disturbances in the psychoemotional state after Covid 19 in women of reproductive age with infertility negatively affect the effectiveness of ART treatment.
FEATURES OF PREGNANCY IN WOMEN WITH CORONAVIRUS DISEASE
Authors: VOROBEY L.I. , FASTOVETS O.P.
Published: March 2023

The aim of the study. Establishing the features of the course of pregnancy and childbirth in pregnant women with coronavirus disease.

Research material and methods. 250 pregnant women were enrolled in the study, of which 150 pregnant women were sick with Covid-19 and 100 pregnant women without Covid-19. The course of pregnancy childbirth and the condition of the newborn was analyzed in both groups. All pregnant women underwent a set of laboratory and instrumental research methods to assess the state of the mother and fetus. Assessment of the condition of the fetus was carried out using ultrasound dopplerometry and fetal cardiotocography.

Research results and their discussion. The results of the retrospective analysis prove the significant impact of the coronavirus disease on the course of pregnancy and childbirth. In particular, such complications as placental insufficiency, oligohydramnios, choriomnionitis and fetal distress occur more often. There is also a significantly higher frequency of preterm delivery, premature birth, caesarean section, newborns asphyxia.

Conclusions. Pregnant women with COVID-19 are subject to detailed observation with the aim of timely detection of pregnancy complications, which includes daily monitoring of the condition of the fetus, determination of markers of inflammation and thrombotic damage.
GENETIC ASPECTS OF ADVERSE CONSEQUENCES OF PREGNANCY WITH ISTHMIC-CERVINAL INSUFFICIENCY
Authors: ISMAILOV R. I.
Published: March 2023

According to modern ideas, both physiological and pathological processes are the result of complex interactions of genetic and epigenetic factors. Among the publications of recent years, there are no studies on the connection of PROGINS and ESR1 gene polymorphisms or gene methylation with ICI and adverse pregnancy outcomes on its background, which prompted us to conduct research in this direction.

The aim of the study. To assess the influence of genetic and eugenetic factors on adverse pregnancy outcomes in isthmic-cervical insufficiency (ICI).

Research material and methods. comprehensively examined 20 pregnant women with ICI, the correction of which was carried out with the use of a cerclage (main group), in which 2 subgroups were distinguished: ICI1 - 10 women with ICI and an unfavorable end of pregnancy (miscarriage before 22 weeks of pregnancy in 4 women and premature birth in 6 patients ) and ICI2 – 20 patients in whom delivery was urgent (after 37 weeks).

A molecular genetic analysis of PGR gene variants (Alu insertion), ESR1 (A351G, rs 9340799) and an epigenetic study of methylation of the promoter region of the estrogen receptor α (ESR1) gene was performed.

The results. Loss of pregnancy and premature birth in ICI can be caused not only by a decrease in hormone levels, but also by a violation of hormonalreceptive relationships. The probability of genetic conditioning of disorders of receptive progesterone and estrogen mechanisms in patients with ICI has been established. The presence in a pregnant woman of the mutant T2 allele of the PGR polymorphism (Alu-insertion) and the combination of homozygous genotypes T2T2+ GG of the polymorphic variants of the PGR (Alu-insertion) and ESR1 (A351G rs9340799) genes can be markers of a high risk of adverse pregnancy termination in ICI. In addition, the change in gene expression can be caused by epigenetic disorders, namely gene methylation: hypermethylation of the promoter region of the estrogen receptor α (ESR1) gene was detected in 40% of women with ICI and pregnancy loss in the II trimester or premature birth, which is 4 times higher than the rate women with ICI and normal termination of pregnancy.

Conclusions. Adverse pregnancy outcomes with ICI can be caused by genetic (presence of a mutant T2 allele of the PGR polymorphism and combinations of homozygous T2T2+ GG genotypes of polymorphic variants of the PGR Alu-insertion and ESR1 A351G genes) and epigenetic factors (hypermethylation of the promoter region of the estrogen receptor α ESR1 gene). However, these results are preliminary and require further indepth studies on larger data samples.
CLINICAL AND ANAMNESTIC CHARACTERISTICS OF REPRODUCTIVE WOMEN WITH RECURRENT FORMS OF VULVOVAGINAL CANDIDIASIS
Authors: SUKHANOVA A. A. , RATUSHNYAK N. YA.
Published: March 2023

Vulvovaginal candidiasis remains an actual problem of lot of women of reproductive age. Despite significant advances in medical science, the percentage of recurrent forms of candidiasis continues to grow.

The purpose of the study is to summarize the set of data on the clinical and anamnestic characteristics of women who contract recurrent forms of vulvovaginal candidiasis.

Study materials and methods. Retrospective analysis of outpatient cards of reproductive women with characteristic complaints of vulvovaginal candidiasis and laboratory confirmation of the disease. Anamnestic data on carry of somatic and gynecological pathology, as well as the presence of concomitant diseases at the present time, were taken into account.

Study results and their discussion. Anamnestic data showed the largest share of women with сoncomitant metabolic syndrome, diseases of the gastrointestinal tract, in particular, noninfective enteritis and colitis. Protective mechanisms counteracting the manifestation of opportunistic pathogens may be deficient in metabolic disorders, in particular, metabolic syndrome and the presence of bowel diseases. Endocrine pathology and diseases of the urinary system were the next most frequently detected. Analysis of generative function and gynecological pathology indicates a hormonal imbalance in the reproductive system and the presence of conditionally pathogenic factors of the inflammatory process.

Conclusions. Somatic pathology has, albeit indirectly, an undeniably significant impact on the risk of recurrence of vulvovaginal candidiasis. A detailed analysis of the clinical and anamnestic data of women with recurrent vulvovaginal candidiasis will allow to optimize the not only treatment regimen, but also prevention of the disease.
La participación de los pueblos indígenas en las políticas públicas de las escuelas rurales en el Perú y los desafíos de la Educación Intercultural Bilingüe en el contexto actual
Authors: Montes  Serrano Uriel , Tineo Quispe Luis Enrique
Published: March 2023

El presente ensayo pretende reflexionar sobre los tipos de participación que tienen los pueblos originarios en la política pública. Su involucramiento en cada una de las etapas es importante para lograr beneficios sociales, políticos, económicos y culturales. Se uso el método de revisión de literatura para comprender que está haciendo el Estado peruano en la educación rural. Una relevante conclusión es que los pueblos originarios participan todavía con limitaciones en el diseño e implementación de las políticas públicas y que todavía padecen etnocidio a través de la minería y tala ilegal y legal, que destruye la biodiversidad, la cosmovisión y la identidad étnica, lo cual se convierte en el desafío para el desarrollo de la educación intercultural bilingüe.
Reseña del libro Fundamentos teóricos de la educación
Authors: Gaeta González Martha Leticia
Published: March 2023

Valentín Martínez-Otero Pérez (2022). Fundamentos Teóricos de la Educación. Editorial Pirámide, Madrid. 208 páginas. ISBN: 978-84-368-4668-3

El libro es un valioso aporte a la actitud de la pedagógica esperanzada, parte del hecho de que la educación aporta elevación y perfeccionamiento, aunque no en el vacío, sino de manera contextualizada. Como tal, esta obra centra las bases cognoscitivas, comprensivas y descriptivas de la educación en íntima conexión con su facticidad, con su realización dondequiera que se produzca. Por lo que constituye un relevante recurso para la educación, expuesta a numerosas contingencias que comprometen también a la teoría en aspectos metodológicos y normativos...
Educación en contextos rurales en Iberoamérica: caminos, perspectivas y desafíos
Authors: De Souza Daniele Cristina , Ribeiro Luiz Paulo
Published: March 2023

Abordar lo rural y la educación dirigida al plantea genera una serie de desafíos, especialmente si la preocupación es expandir una lectura más allá de Brasil. Entramos en un campo de producción de conocimiento interdisciplinario que requiere desde nuestra visión especializada en educación un esfuerzo integral de problemas, temas y construcciones teóricas que no son priorizadas en el área, pero que son fundamentos en/desde nuestra práctica social. Esta edición especial de la Revista Iberoamericana de Educación trae investigaciones, informes y reflexiones sobre la Educación en Contextos Rurales de Iberoamérica, demostrando la pluralidad de prácticas frente a las diferencias contextuales y los desafíos y potencialidades comunes para construir una educación que represente y se produzca en los pueblos del ámbito iberoamericano. El texto pretende hacer una introducción a este monográfico, presentando discusiones iniciales y potenciando la lectura a los interesados en (re)conocer la educación rural y del campo en Iberoamérica.
A Comprehensive Review of Feature Selection and Feature Selection Stability in Machine Learning
Authors: BÜYÜKKEÇECİ Mustafa , OKUR Mehmet Cudi
Published: March 2023

Feature selection is a dimension reduction technique used to select features that are relevant to machine learning tasks. Reducing the dataset size by eliminating redundant and irrelevant features plays a pivotal role in increasing the performance of machine learning algorithms, speeding up the learning process, and building simple models. The apparent need for feature selection has aroused considerable interest amongst researchers and has caused feature selection to find a wide range of application domains including text mining, pattern recognition, cybersecurity, bioinformatics, and big data. As a result, over the years, a substantial amount of literature has been published on feature selection and a wide variety of feature selection methods have been proposed. The quality of feature selection algorithms is measured not only by evaluating the quality of the models built using the features they select, or by the clustering tendencies of the features they select, but also by their stability. Therefore, this study focused on feature selection and feature selection stability. In the pages that follow, general concepts and methods of feature selection, feature selection stability, stability measures, and reasons and solutions for instability are discussed.
Muestreo y Calidad del Agua
Authors: Herrera-Morales Greys Carolina , Jiménez-Gutiérrez Mirian Yolanda , Cabezas-Andrade Leonardo Daniel
Published: March 2023

El libro tiene como propósito orientar al lector al uso racional del agua, así como de conocer algunas técnicas o estrategias para mantener la calidad de la misma, aprovechándose para ser consumida y por las especies vivas. En el primer capítulo, se aborda la importancia de un monitoreo de la calidad del agua con la intención de propiciar en el lector, una cercanía con el vital líquido desde el parámetro de prevención y control de la contaminación que amenaza con destruirla. En el segundo capítulo, se describen las características del agua, tanto en formo como en contenido, mientras que, en el último, se hace mención de los principales métodos de análisis de los elementos que contiene el agua.
Effectiveness of disinfecting substances of gutta-percha cones
Authors: Rozendo Daiana Moreira Mendes , Alcino Andressa Batista Mendes , Domingueti Catherine Bueno , Silva Naiara Chaves , Moreira Geovane Evangelista , Pereira Patrícia Peres Iucif , Gonçalves Lísia Aparecida Costa
Published: March 2023

Aim: To demonstrate the effectiveness of disinfecting substances with 2% and 5% Sodium Hypochlorite and 2% Chlorhexidine Gluconate at each of the pre-established times of 0:15 and 0:30 seconds, and 1, 2, 5, and 10 minutes.
Methods: This study selected 96 gutta-percha cones that were contaminated with Enterococcus Faecalis, dried and treated with the aforementioned substances and applied at pre-established times. Subsequently, these were transferred to sterile Brain Heart Infusion broth and placed in a bacteriological incubator at 37°C for 24 hours to evaluate microbial growth, as well as in a nutrient agar medium in Petri dishes. Half of the cone was transferred to individual filter paper packages and exposed to the environment in a dental clinic at Universidade José do Rosário Velano, for 7 days, with subsequent evaluation for microbial growth. The bacterial phenotype test was performed using Gram stain and growth in 6.5% saline solution. The results were submitted to statistical analysis using the Kruskal Wallis H test, with a significance level of 5%.
Results: The substances were effective at all times tested and individual storage supported disinfection. In the statistics test, the p-value was greater than 0.05, as there was no variability in the data configurations.
Conclusion: The disinfection of gutta-percha cones and individual storage was an effective protocol to be adopted with 2% and 5% Sodium Hypochlorite and 2% Chlorhexidine.
Impacto do isolamento social pela pandemia da COVID-19 nas consultas odontopediátricas
Authors: Magnani Isabela Queiroz , Souza Gabriela Luíza Nunes , Abreu Lucas Guimarães
Published: March 2023

Objetivo: Avaliar estudos que mostraram o impacto do isolamento social pela pandemia da COVID-19 nas consultas odontopediátricas.
Métodos: Estudos originais que tenham mostrado o impacto do isolamento social nas consultas de crianças e adolescentes com um(a) odontopediatra foram incluídos. Buscas no Web of Science, Scopus, Embase e PubMed foram realizadas. A seleção dos estudos foi feita por dois autores. O risco de viés foi avaliado com a escala Universidade de Adelaide. Resultados das meta-análises foram fornecidos em razão de chances (RC) e intervalo de confiança (IC).
Resultados: Setecentas e noventa e quatro referências foram avaliadas e quatro estudos foram incluídos. A proporção de consultas realizadas em 2019 (antes da pandemia) para tratamento restaurador (RC = 22,65; IC = 20,57–24,93), extração de dentes (RC = 15,96; IC = 14,78–17,23) e tratamento endodôntico (RC = 9,21; IC = 7,72–10,98) foi significativamente maior que a proporção de consultas realizadas em 2020 (após o início da pandemia). A proporção de pais/responsáveis que não levariam seus(suas) filhos(as) à uma consulta com o odontopediatra foi significativamente maior entre indivíduos com mais medo durante a pandemia (escore 6 a 10) do que entre indivíduos com menos medo durante a pandemia (escore 0 a 5) (RC = 8,41; IC = 5,06–13,98). A proporção de pais/responsáveis que não levariam seus(suas) filhos(as) à uma consulta com o odontopediatra em regiões com mais de 100 casos de COVID-19 foi significativamente maior do que em regiões com até 100 casos (RC = 2,45; IC = 1,55–3,88). A avaliação do risco de viés variou de baixo a alto. Uma limitação dessa revisão foi o número restrito de estudos incluídos.
Conclusão: O isolamento social pode ter contribuído para uma redução no número de consultas odontopediátricas devido à insegurança dos pais de levarem seus(suas) filhos(as) ao consultório odontológico. Esses resultados podem ser importantes para os clínicos e os organizadores de serviços de saúde.
Coocorrência de palavras-chave em dados abertos da Capes
Authors: Marques Francis Bento , Marques Yuri Bento , Maculan Benildes Coura Moreira dos Santos
Published: March 2023

O grande volume de dados produzidos, armazenados e disponibilizados para acesso tornou os computadores imprescindíveis para transformá-los em informação processável pelo homem. Com a mineração de textos, as palavras extraídas podem ser utilizadas no apontamento de relações entre elementos textuais internos ou externos a eles. Neste estudo, apresenta-se uma pesquisa em andamento que busca a descoberta de padrões de coocorrência de palavras-chave nas dissertações e teses do domínio da Ciência da Informação brasileira, utilizando técnicas de inteligência artificial aplicadas aos dados abertos da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Capes). A metodologia se caracteriza como de natureza aplicada, com objetivos exploratórios de descritivos, e com procedimentos de análise quanti-qualitativos. O método utilizado é quantitativo, na forma de um estudo métrico, com a análise baseada nos princípios da teoria dos grafos. Espera-se que os resultados evidenciem a possibilidade de parcerias entre pesquisadores, tendências de pesquisa, temas pouco explorados, entre outros elementos.
Demonstration of stereophonic projection lithography using parabolic mirror optics and collimated illumination from one side
Authors: Horiuchi Toshiyuki , Iwasaki Jun-ya , Kobayashi Hiroshi
Published: March 2023

Capability of stereophonic projection lithography on arbitrarily but gently curved surfaces was demonstrated using plastic spoons as a reticle and specimens to be patterned. It had already been clarified that the patterned area size was drastically enlarged by illuminating the transparent reticle obliquely upward by collimated light from one side. Here, it was confirmed at first that 200 μm line-and-space patterns in 10 mm square area on a flat reticle were stably replicated on Si wafers with large exposure-time and focus margins. Next, reticle patterns on a spoon concave were successfully replicated on convex surfaces of specimen spoons. On the other hand, it was clarified that resist pattern field was distorted in a warped trapezoid, and pattern sizes were also varied similarly. However, because the distortions are regular and systematic, they are probably no problem, if critical overlays are not required. And, the distortions can be compensated by modifying the reticle, if necessary.
Mass spectrometric study of β-Ga2O3 growth process by metalorganic vapor phase epitaxy
Authors: Ikenaga Kazutada , Okuyama Takahito , Tozato Haruka , Nishimura Taro , Sasaki Shogo , Goto Ken , Ishikawa Masato , Takinami Yoshihiko , Machida Hideaki , Kumagai Yoshinao
Published: March 2023

In metalorganic vapor phase epitaxy of β-Ga2O3 using triethylgallium (TEGa) and O2 as precursors and Ar as the carrier gas, the gases directly above the substrate were sampled and analyzed by time-of-flight mass spectrometry. TEGa was found to decompose at 400 °C–600 °C via β-hydrogen elimination reaction to generate gaseous Ga, hydrocarbons (C2H4, C2H2, C2H6), and H2. When β-Ga2O3 was grown at temperatures greater than 1000 °C and with input VI/III ratios greater than 100, the hydrocarbons and H2 were combusted and CO2 and H2O were generated. The C and H impurity concentrations measured by secondary-ion mass spectrometry in the β-Ga2O3(010) homoepitaxial layer grown under these conditions were less than their respective background levels. Thus, to grow β-Ga2O3 without C and H contamination, conditions that favor the complete combustion of hydrocarbons and H2 generated by the decomposition of TEGa should be used.
Pengaruh Kompetensi, Budaya Organisasi dan Disiplin Terhadap Kinerja Pegawai di Kementerian Agama Kabupaten Simalungun
Authors: Dermawan MHD Rizki , Matondang Abdul Rahim , Absah Yeni
Published: March 2023

Penelitian ini bertujuan untuk Menguji pengaruh kompetensi, budaya organisasi dan disiplin kerja terhadap kinerja pegawai di Kementerian Agama Kabupaten Simalungun. Penelitian ini dibuat dengan menggunakan metode deskriptif kuantitatif. Objek penelitian adalah pegawai di Kementerian Agama Kabupaten Simalugun. Populasi adalah seluruh pegawai pada Kementerian Agama Kabupaten Simalugun yang berjumlah  553 orang pegawai. Sampel pada penelitian ini adalah 233 pegawai. Teknik analisis yang digunakan analisis regresi linier berganda. Hasil penelitian menunjukkan secara simultan kompetensi, budaya organisasi dan disiplin kerja berpengaruh terhadap kinerja pegawai. Secara parsial kompetensi berpengaruh terhadap kinerja pegawai, budaya organisasi berpengaruh terhadap kinerja pegawai, dan disiplin kerja berpengaruh terhadap kinerja pegawai.
Analysis on Disasters Caused by Climatic Changes in Nature
Authors:   Department of Computer Science and Engineering, Jain Global Campus, Bangalore (Karnataka), India, Reddy A Akhil Kumar , S Swaroop ,   Department of Computer Science and Engineering, Jain Global Campus, Bangalore (Karnataka), India, Nitika Achammagari ,   Department of Computer Science and Engineering, Jain Global Campus, Bangalore (Karnataka), India, kumar P Sai Pranav ,   Department of Computer Science and Engineering, Jain Global Campus, Bangalore (Karnataka), India, Rishitha P. ,   Department of Computer Science and Engineering, Jain Global Campus, Bangalore (Karnataka), India
Published: March 2023

On Earth, humans are not the only living beings who are living and there is a lot of wrongdoing by humans on Earth. As our body works, the earth also works. In our body, if we have some disease or something else our immune system starts working, in the same way, the earth has some effects of our human actions like pollution deforestation, and all other harms which we do to nature which affect the flow of nature in corresponding ways like climate change which causes natural disaster to form on our earth which cannot be controlled by humans. Due to heavy rain in the oceans water level gets more and more and we have tsunamis due to high wind we have cyclones that tear apart anything that gets in their way. These are all caused by different climate conditions. These climate conditions can be determined by their parameters like humidity, wind, temperature, etc. These affect the climate to change in a drastic way which leads to natural disaster formation. This four our daily life as it is and destroys anything in their ways. Let's check some of those parameters in detail and some disasters which had happened due to those climate changes.
Design, Fabrication and Characterization of Antiemetic Transdermal Patches Loaded Dissolvable Microneedles
Authors:   Department of Pharmaceutics, Research Scholar, Bhagwant University, Ajmer (Rajasthan), India, Lall Deepesh , Sharma Dr. Neeraj ,   Department of Pharmaceutics, Professor/ Principal, Bhagwant University, Ajmer (Rajasthan), India, Rathore Dr. Shruti Rathore, ,   Department of Pharmaceutics, Professor/ Principal, LCIT School of Pharmacy, Bilaspur (Chhattisgarh), India
Published: March 2023

Various non-invasive administration has been recently coming as an excellent alternative to conventional administrative mechanism. A transdermal drug delivery system with polymeric microneedles presents the most attractive method among all these because of its low rejection rate, higher bioavailability, super convenience, ease of administration and ease of termination, biodegradable and persistence in the skin care industry. However, the skin physiochemical properties made them to protect the inner environment and this mechanism play as excellent barrier for TDDS, hence polymeric bio dissolvable and biocompatible microneedle can be excellent choice. In this research, we fabricated and characterized the different proportions of polymer blend solution for effective and improved bioavailability and delivery of Ondansetron HCl. We characterized TDDS on progression of mechanically strength determination by folding endurance, flatness study, gelatin sheets beds penetration application, percentage drug content releasement under FT-IR and studied microscopic images the shape and size of microneedle. In addition, desired physical properties and an excellent alternative method had been established with high efficiency inherent to TDDS which expected to find a broad range of application fields.