bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of polymorphic variants genes ESR1 и PGR in women with miscarriage
Authors: О.С. Абрамовских, , Ю.В. Логинова,
Published: January 2023

Невынашивание беременности (НБ) - многофакторное заболевание, развитие которого обусловлено взаимодействием множества факторов, в том числе генетических, среди которых особое внимание уделяется полиморфным вариантам генов рецепторов половых гормонов (ESR1, PGR). Данные ряда научных работ по изучению ассоциации однонуклеотидных полиморфизмов (SNP) rs9340799 и rs2234693 гена ESR1 и rs10895068 гена PGR с риском развития НБ у женщин неоднозначны, что, вероятно, связано с популяционными особенностями распределения частот аллелей и генотипов указанных SNP. Данные нашего исследования направлены на изучение роли rs9340799 и rs2234693 гена ESR1 и rs10895068 гена PGR в развитии НБ у женщин, проживающих на территории г. Челябинска и Челябинской области. Материалом для исследования послужили образцы ДНК, выделенные из лейкоцитов периферической венозной крови. Анализ SNP генов проводили методом ПЦР в режиме реального времени. Установлено, что аллель С и генотип С/С rs2234693 гена ESR1 статистически значимо реже регистрируются в группе женщин, имеющих в анамнезе 3 и более прерывания беременности, в сравнении с условно здоровыми женщинами без отягощенного акушерско-гинекологического анамнеза и группой женщин с НБ. На основе полученных данных можно предположить вероятное протективное действие аллеля С и генотипа С/С rs2234693 гена ESR1 в отношение риска развития привычного НБ.

Miscarriage is a multifactorial disease, the development of which is caused by the interaction of many factors, including genetic ones, among which special attention is paid to polymorphic variants of sex hormone receptor genes (ESR1, PGR). The data of a number of scientific papers on the association of single nucleotide polymorphisms rs9340799 and rs2234693 of the ESR1 gene and rs10895068 of the PGR gene with the risk of miscarriage in women are ambiguous, which is probably due to population characteristics of the frequency distribution alleles and genotypes of the indicated SNPs. The data of our study are aimed at studying the role of rs9340799 and rs2234693 of the ESR1 gene and rs10895068 of the PGR gene in the development of miscarriage in women living in the city of Chelyabinsk and the Chelyabinsk region. The material for the study was DNA samples isolated from peripheral venous blood leukocytes. The analysis of single nucleotide gene polymorphisms was carried out by real-time PCR. It was found that the C allele and the C/C genotype rs2234693 of the ESR1 gene is significantly more often registered in the group of women with a history of up to 2 abortions, as well as in the group of apparently healthy women without a burdened obstetric and gynecological history. Based on the data obtained, it can be assumed that the C allele and the C/C genotype rs2234693 of the ESR1 gene have a probable protective effect on the risk of recurrent miscarriage.
Comparative characteristics of cytokine gene polymorphism in children with different variants of bronchial asthma
Authors: М.А. Малинчик, , М.В. Смольникова,
Published: January 2023

Бронхиальная астма - гетерогенное воспалительное заболевание легких мультифакториальной природы, связанное с дисбалансом между провоспалительными и противовоспалительными цитокинами и характеризующееся генетической детерминированностью. Большая часть больных тяжелой астмой относится к T2-эндотипу и имеет эозинофильное воспаление в слизистой нижних дыхательных путей. Цель исследования - проанализировать распределение генотипов IL4 rs2243250, IL5 rs2069812, IL13 rs1800925 у детей с различными фенотипами бронхиальной астмы. Генотипирование полиморфизмов проводили методом РТ-ПЦР. В ходе исследования показано, что частота генотипа TT и аллеля T rs1800925 IL13 значимо выше у больных с эозинофильным фенотипом астмы по сравнению с контрольной группой здоровых детей (p<0,05).

Asthma is a complex,multifactorial and heterogenic inflammatory disease of the airways, associated withan imbalance between pro-inflammatory and anti-inflammatory cytokines and characterized by genetic determinism. Most patients with severe asthma are classified as T2-endotypeand have eosinophilic inflammation in the mucosa of the lower respiratory tract. The aim of the study was to analyze the distribution of genotypes IL4 rs2243250, IL5 rs2069812, IL13 rs1800925 in children with different phenotypes of bronchial asthma. Genotyping of polymorphisms was performedusing RT-PCR. The frequency of the TT genotype and the T allele rs1800925 IL13 has been shown to be significantly higher in patients with the eosinophilic asthma phenotype compared with a control group of healthy children (p<0,05).
Molecular-genetic analysis of Rubinstein-Taybi syndrome in Russia
Authors: О.Р. Исмагилова, , Т.А. Адян, , Т.С. Бескоровайная, , А.В. Поляков,
Published: January 2023

Синдром Рубинштейна-Тейби (СРТ) - редкая наследственная патология, характеризующаяся умственной отсталостью и задержкой физического развития в сочетании с определённым комплексом внешних проявлений и аномалиями различных органов и систем. Диагностический алгоритм нацелен на поиск мутаций в двух основных генах: CREBBP и EP300, обнаруживаемых примерно в 60% клинически определённых случаев СРТ. В настоящей работе представлены результаты молекулярно-генетического анализа выборки российских пациентов с СРТ. Несмотря на то, что около 40% пациентов не получают подтверждения клинического диагноза, существуют перспективы для более глубокого понимания патогенеза заболевания и усовершенствования принципов диагностики.

Rubinstein-Taybi syndrome (RTS) - rare hereditary disorder characterized by intellectual disability and growth retardation in conjunction with specific craniofacial and skeletal features and a wide range of multiple congenital anomalies. To date, mutations in two genes: CREBBP and EP300 can be discovered in about 60% of clinically identified patients with RTS. We herein report the result of molecular analysis in a cohort of Russian RTS patients. Despite the fact that we cannot confirm the diagnosis of RTS in 40% of causes, there are possibility for a better understanding of causative molecular mechanisms and improving the diagnostic process.
Spastic paraplegia type 47 in Russian patients
Authors: В.А. Кадникова, , Г.Е. Руденская, , О.Л. Шатохина, , Д.М. Гусева, , О.П. Рыжкова,
Published: January 2023

Гомозиготные и компаунд-гетерозиготные мутации в гене AP4B1 приводят к спастической параплегии SPG47. Для неё характерны микроцефалия, гипоплазия мозолистого тела, неонатальная мышечная гипотония, сменяющаяся спастичностью, а также тяжелая умственная отсталость. Повторяющийся вариант c.1160_1161del был выявлен у шести пациентов из неродственных неинбредных семей. Был проведен анализ гаплотипов гена AP4B1 у четырех из шести больных на хромосомах с этой мутацией, в результате чего не выявлено единственного гаплотипа, сцепленного с данным вариантом. Таким образом, он может быть, как горячей точкой, так и распространиться в результате эффекта основателя.

The reason of SPG47 is homozygous and compound-heterozygous mutations in AP4B1 gene. SPG47 is characterized by microcephaly, corpus callosum hypoplasia, neonatal muscular hypotension, followed by spasticity and severe mental retardation. Variant c.1160_1161del was identified in six patients from unrelated, non-consanguineous families. Was performed haplotype analysis AP4B1 gene for four from six patients on chromosomes with this variant. As a result, there wasn’t found the only haplotype linked to this variant. Therefore, this variant can be a “hot spot” mutation, or could have spread as a result the founder effect.
Translating Performance Level to Clinical Frailty Scale Category Simplifies Scoring and Indicates Length of Stay and Outcome: A Longitudinal Observational Study
Authors:   Population Health Sciences Institute, Newcastle University, Westgate Road, Newcastle Upon Tyne, NE4 6BE, D Stow , K Frew ,   Northumbria Healthcare NHS Foundation Trust, Westgate Road, Newcastle Upon Tyne, NE4 6BE, P Paes ,   Northumbria Healthcare NHS Foundation Trust, Westgate Road, Newcastle Upon Tyne, NE4 6BE, B Hanratty ,   Population Health Sciences Institute, Newcastle University, Westgate Road, Newcastle Upon Tyne, NE4 6BE
Published: January 2023

Objectives: To group performance level scores of hospice inpatients using the clinical frailty scale to explore the association between performance, frailty, outcomes and Length of Stay (LOS). Methods: Australia-modified-Karnofsky-Status was recorded for admissions to three hospices in England (April 2017 to April 2018) and cross-mapped to the Clinical-Frailty-Scale. We explored relationships between performance, frailty, demographics, diagnosis, LOS, and outcome (death/discharge) using Kaplan- Meier survival curves and logistic regression. Results: 419 admissions were recorded from 406 people (51.8% female, mean age=69.0, sd=13.1).158 (37%) were severely/very severely frail (AKPS 10-30) on admission. Of these, 140(88.7%) died after a short stay (median 11.5 and 5.0 days respectively). 112(26.7%) had no/mild frailty (AKPS 60-100) at admission. Of these, 82(73%) were discharged after(median) 23 and 28 days respectively. 149 people had moderate frailty(AKPS 40-50), 126(84.6%)of these were admitted for symptom control, but most(n=93, 62.4%) died after(median)19 days. In this group, frailty was stable in people who were discharged, and declined rapidly over the 14 days before death in decedents. Similar patterns were observed across cancer and non-cancer patients. Conclusions: Measuring frailty, or dividing performance scores using frailty categories, could support decision making in hospices. Frailty seems to divide cancer and non-cancer hospice-inpatients into three groups: Those with severe frailty, at high risk of dying with short LOS. Patients with mild/no frailty, moderate LOS and high discharge rates. Those with moderate frailty, long LOS and similar rates of discharge/death. However, the latter two groups are targets for future research as associations between frailty and length of stay were less clear.
Psychological Impact of Cancer Risk Assessment: Anxiety, Depression and Distress in an Italian Sample
Authors:   Heredo-Familiar Cancer Unit, Experimental Oncology and Biobank Unit, IRCCS Istituto Tumori “Giovanni Paolo II”, Bari, Italy, S Costanzo , S De Summa ,   Molecular Diagnostics and Pharmacogenetics Unit, IRCCS - Istituto Tumori “Giovanni Paolo II”, Bari, Italy, F Romito ,   Psycho-Oncology Service, IRCCS Istituto Tumori “Giovanni Paolo II”, Bari, Italy, M Digennaro ,   Heredo-Familiar Cancer Unit, Experimental Oncology and Biobank Unit, IRCCS Istituto Tumori “Giovanni Paolo II”, Bari, Italy, M Ronchi ,   Unità operativa di Medicina Oncologica per la presa in carico del paziente oncologico, IRCCS - Istituto Tumori “Giovanni Paolo II”, Bari, Italy, A Paradiso ,   Heredo-Familiar Cancer Unit, Experimental Oncology and Biobank Unit, IRCCS Istituto Tumori “Giovanni Paolo II”, Bari, Italy, M Patruno ,   Heredo-Familiar Cancer Unit, Experimental Oncology and Biobank Unit, IRCCS Istituto Tumori “Giovanni Paolo II”, Bari, Italy
Published: January 2023

Purpose: Evaluating whether and how anxious and depressive symptoms change from prior to Oncological Genetic Counseling (OGC) to one month following BRCA genetic test result. Short-term psychological impact of genetic test disclosure in an Italian sample was also assessed. Methods: 106 Italian natives completed Hospital Anxiety and Depression scale (HADs) both before accessing OGC (t1) and one month following their test result (t2). In t2 they also completed the Italian translation of Multidimensional Cancer Risk Assessment (MICRA). Results: An overall reduction of HADs scores over time in BRCA-carriers was observed. Higher distress median values (MICRA) were found in carriers than non-carriers. Discussion: In carriers, the simultaneous presence of both a reduction of anxiety/depression and a greater distress should be explained basing on Post- Traumatic-Growth studies in cancer patients. Being a carrier may represent an explanation for cancer disease, and allow patients to access specific riskreduction programs.
Disease Course and Patient’s Characteristics in a Regional First Level Hospital in Western-Germany During the First Three Covid-19 Surges from March 2020 to July 2021
Authors:   Department of Internal Medicine, Sankt Marienwoerth Hospital, Germany, Julia Goller , Mark Ratayczak ,   Department of Internal Medicine, Sankt Marienwoerth Hospital, Germany, Markus Dahlem ,   Department of Internal Medicine, Sankt Marienwoerth Hospital, Germany, M Bracko ,   Department of Internal Medicine, Sankt Marienwoerth Hospital, Germany, Clemens Ballmann ,   Department of Internal Medicine, Sankt Marienwoerth Hospital, Germany, Thomas Middeldorf ,   Department of Internal Medicine, Sankt Marienwoerth Hospital, Germany, Hendrik Lengfeld ,   Department of Internal Medicine, Sankt Marienwoerth Hospital, Germany, Gabriele Ess ,   Department of Internal Medicine, Sankt Marienwoerth Hospital, Germany, Oliver Bill ,   Department of Internal Medicine, Sankt Marienwoerth Hospital, Germany, G Tekin ,   Department of Internal Medicine, Sankt Marienwoerth Hospital, Germany, Volker Schmitz ,   Department of Internal Medicine, Sankt Marienwoerth Hospital, Germany
Published: January 2023

The worldwide spread of SARS-CoV-2 profoundly affected almost all aspects of public life and challenged international and national health institutions of all different medical care levels including Europe up from the very beginning in 2020 until today. Public and press perception might have been weighed somehow towards third level health care providers offering treatment options like ECMO therapy for Covid-19 patients with the worst disease course, the majority of patients who needed hospital care were treated in hospitals of the first level. These hospitals provided about 50% of intensive care treatments in the federal state of Rhineland Palatinate (RLP) in Germany, too [1]. According to the Destatis [2] about 71000 additional deaths were registered in Germany during the first 12 months (02/2020 – 02/2021) of pandemic of which about 50000 could be attributed to Covid-19 as given in the medical death reports. However, only few data has been published on the concrete disease course and patient´s outcome on the scale of a single treatment site. Thus, this analysis provides routine data on patient´s characteristics, treatment modalities and outcome in a single first level hospital in RLP during the first three Covid-19 surges during 03/2020 – 07/2021.
Liposomes: A Promising Strategy to Treat Multidrug Resistance in Cancers
Authors:   State Institute of Nursing and Paramedical Sciences, Badal, India, R Kaur , S Mann ,   Surrey Memorial Hospital- Neurology, Canada, SS Hallan ,   Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Italy
Published: January 2023

Drug resistance has become a main concern in the cancer therapy worldwide. It can be a temporary or permanent potential of an organismto multiply even in the presence of the lethal drug concentration.Generally, multidrug resistance (MDR) is associated with the over-expression of P-glycoprotein(P-gp), resulting in amplified efflux of anticancer drug molecules from cancer cells [1]. Therefore, interrupting the P-gp efflux might be an effective strategy to resolve the MDR in cancer patients. Interestingly, smart nano-sized transporters can deliver the drug cargo at the proposed site and release the drug precisely to elicit desirable therapeutic response. Thanks to their small diameter, large surface area. Now a days, researchers have explored a smart drug delivery system known as polymer lipid hybrid nanoparticles, which are capable to combat various diseases [2,3]. Over expressed ATP-Binding Cassette (ABC) transporters is frequently associated with MDR in cancer treatments. However, no approved anti-cancer drug molecules are available for clinical use in order to reverse MDR by obstructing P-glycoprotein. However, MDR is responsible for the low intracellular drug concentrations ultimately reduce the cytotoxicity of a broad spectrum of antitumor drugs including anthracyclines (e.g. DOX), vinca alkaloids (e.g. vincristine), podophyllotoxins (e.g. etoposide) and taxanes (e.g. taxol) [4].
Role of Cholesterol in Interaction of Ionic Liquid with Model Lipid Membranes and Associated Permeability
Authors: Kumar Sandeep , Kaur Navleen , Mithu Venus Singh
Published: January 2023

In this work, we have investigated the impact of composition of cholesterol in the lipid membrane composed of phosphatidylcholine (POPC) or phosphatidylglycerol (POPG) on the membrane permeability induced by 1-dodecyl-3-methylimidazolium bromide ([C12MIM]+Br-) ionic liquid using various biophysical techniques. We investigated four different compositions of cholesterol (10, 20, 30, and 40 mole%) both with POPC and POPC phospholipids. Membrane permeability was determined using steady-fluorescence-based dye leakage assay. Further, interaction of ionic liquid with lipid membranes was investigated using ζ-potential measurements, and dynamic light scattering for measuring the size distribution. POPC and POPG membranes both show a reduction in [C12MIM]+ induced membrane permeability in the presence of cholesterol which continues with a further increase in cholesterol content. The overall reduction in membrane permeability is more in POPG LUVs in the presence of 30 and 40 mol% cholesterol content. Besides this, cholesterol also impacts the [C12MIM]+Br--induced fusion of POPC and POPG LUVs at higher ionic liquid concentrations. POPG membranes become more fusion prone in the presence of cholesterol as compared to POPC lipid membrane.
Imaging ice growth and nucleation inside non-transparent materials using micro-thermography
Authors: Zalazar Martin , Drori Ran
Published: January 2023

Ice nucleation and recrystallization plays a central role in our daily lives and understanding these processes will have great implications. The measurement of ice nucleation, growth and melting is usually done using light microscopy in liquid and transparent samples. However, crystal growth inside solid materials such as food products, cementitious materials and biological samples is more complex. Imaging ice inside these non-transparent materials would be beneficial in many ways since rapid ice growth leads to structural damage of food, and the weakening of the final structure of cementitious materials. Thermography is a technique that uses thermal (Infra-red) cameras to monitor temperature changes in a material, and it has been used to provide qualitative description of ice propagation and nucleation with a spatial resolution of millimeters. Here, the use of a novel micro-thermography system to image ice nucleation, growth and melting inside non-transparent samples with an emphasis on biological samples is described. This method relies on two major players; a cold stage with accurate temperature control (±0.001 ºC) coupled to a high-resolution (both temperature and spatial) thermal camera. The coupling of these instruments brings about the ability to measure the kinetics of ice growth and nucleation inside a variety of non-transparent samples. These experiments provide strong evidence for the high-quality imaging of ice growth, thus leading to quantitative measurements of ice growth velocity and ice nucleation in solid materials.
Catalytic Amide Activation with Thermally Stable Molybdenum(VI) Dioxide Complexes
Authors: Evenson Garrett , Powell Wyatt , Hinds Aaron , Walczak Maciej
Published: January 2023

Oxazolines and thiazolines are important constituents of bioactive natural products and pharmaceuticals. Here, we report the development of an effective and practical method of oxazoline and thiazoline formation, which can facilitate the synthesis of natural products, chiral ligands, and pharmaceutical intermediates. This method capitalized on a Mo(VI) dioxide catalyst stabilized by substituted picolinic acid ligands, which is tolerant to many functional groups that would otherwise be sensitive to highly electrophilic alternative reagents.
A universal basic income for Ireland: Lessons from the international literature
Authors:   ESRI, Redmond Paul , McGuinness Seamus ,   ESRI, Ciprikis Klavs ,   ESRI
Published: January 2023

A universal basic income (UBI) is defined as a universal, unconditional cash payment that is made regularly, is sufficient to live on, is not means tested, carries no work requirements and is paid on an individual basis. This study examines the international evidence on universal basic incomes and identifies key issues for consideration in the design of any UBI pilot for Ireland. Despite the mainstream interest in UBI as a potential policy tool, relatively little is known about the associated consequences of such policies. Even the definition of a UBI appears to be poorly understood and is often misused in the public discourse. Several pilot studies have been recently implemented across different countries. However, some pilot studies depart from the accepted definition of UBI. For example, some are not universal, in that they only target a specific subgroup of the population and/or have eligibility restrictions based on earnings. Others provide a relatively low level of payment, which may fall short of what an individual could reasonably be expected to live on. There are a number of potentially positive impacts associated with a UBI. A universal, unconditional payment could eliminate the stigma associated with welfare receipt. If replacing existing welfare payments, a UBI would also involve lower transaction costs, both on the recipient (in terms of the application procedure) and on Government (in terms of administering the payment). Universal, unconditional payments would also avoid situations where people choose not to work in order to retain means-tested benefits. UBI could give individuals the freedom to turn down or leave insecure, exploitative or low-paid work in pursuit of better or improved work opportunities. In addition, it would mean that persons in informal and often unpaid work, such as childcare and eldercare, which is mostly done by women, receive some compensation for their labour. Empirical results from several pilot studies have found evidence of positive health impacts following the implementation of a UBI. In terms of potential disadvantages, a UBI, by definition, may not target those that are most in need, as a large percentage of recipients will be high-earning individuals. Furthermore, the cost of a UBI is likely to be very expensive, even if other existing benefits (such as unemployment benefits) are no longer required. The net impacts of a UBI on labour supply are unclear, with both positive and negative influences on labour market participation potentially arising as a consequence of a UBI. In this study, we undertake some basic calculations relating to four possible UBI approaches, all of which would involve an unconditional payment to every individual aged over 18 in Ireland.
Evaluation of metabolic disorders and aging rates depending on SIRT1 polymorphism in patients with arterial hypertension and subclinical hypothyroidism
Authors: Radchenko A.O. , Kolesnikova O.V.
Published: January 2023

There is an increase in the frequency and severity of metabolic disorders in patients with arterial hypertension (AH) in combination with subclinical hypothyroidism (SH), that is accompanied by accelerated aging rates, but the research findings on the aging rates in this category of patients are extremely few in number. Therefore, the aim of our study was to assess metabolic disorders and the aging rates depending on the SIRT1 rs7069102 polymorphism in patients with AH and SH. A total of 132 patients with a median age of 47.6 years were included in the study and divided into 3 groups: a control group (n=30), a group of patients with AH without SH (n=49) and patients with AH in combination with SH (n=53). Anthropometric parameters, biochemical parameters, pro-inflammatory and oxidative states were evaluated in all pa­tients. The aging rates were assessed using two different methods. The frequencies of SIRT1 rs7069102 genotypes carriers in the study sample of patients were 8% for the CC genotype, 51% for the CG genotype and 41% for the GG genotype. There was a significant difference in the incidence of CC homozygosity and carriers of the G allele between groups of patients with AH depending on the SH presence (p<0.001). We showed that carriers of the G allele and GG genotype of the SIRT1 gene (rs7069102) polymorphic marker with AH and SH had significantly higher (p<0.05) insulin resistance, higher levels of low-density lipoprotein cholesterol, alkaline phosphatase, C-reactive protein and lower glomerular filtration rate, which negatively affected the aging processes in this category of patients. In addition, patients with AH had a marked effect of carrying the G allele on the lipid profile and biological age of patients. Therefore, timely detection of a polymorphic variant of the SIRT1 gene may be effective in premature aging prevention in patients with AH and SH.
Piękny Syn. Zarys estetyki teologicznej Tomasza z Akwinu
Authors: Gałuszka OP Tomasz
Published: January 2023

Artykuł dotyczy zagadnienia estetyki teologicznej św. Tomasza z Akwinu. Autor przedstawia z perspektywy trynitologicznej i chrystologicznej dwie definicje piękna sformułowane przez Akwinatę: pierwsza tzw. subiektywna, w której kluczowe są role obserwatora, percepcji oraz doświadczenia; druga tzw. obiektywna, w której omówione zostały trzy kategorie: integritas (pełnia), proportio (harmonia, współbrzmienie), claritas (blask).
Przyjaźń w Etyce Nikomachejskiej Arystotelesa oraz w Czterech Miłościach C. S. Lewisa. Paralela komparatystyczna
Authors: Pyż Kacper
Published: January 2023

Celem artykułu jest próba filozoficznej rekonstrukcji i porównania koncepcji przyjaźni Arystotelesa oraz C. S. Lewisa. Artykuł powstał w oparciu o poglądy obu autorów przedstawione w VIII i IX księdze Etyki Nikomachejskiej Arystotelesa oraz w czwartym rozdziale Czterech Miłości C. S. Lewisa. Na podstawie krytycznej analizy tekstów źródłowych i uzupełniających udało się ustalić cechy wspólne oraz główne różnice obu koncepcji, a także wskazać na możliwości dalszych badań odnośnie koncepcji przyjaźni C. S. Lewisa.
Genomic surveillance of SARS-CoV-2 positive passengers on flights from China to Italy, December 2022
Authors: Novazzi Federica , Giombini Emanuela , Rueca Martina , Baj Andreina , Fabeni Lavinia , Genoni Angelo , Ferrante Francesca Drago , Gramigna Giulia , Gruber Cesare Ernesto Maria , Boutahar Sara , Minosse Claudia , Butera Ornella , Pasciuta Renee , Focosi Daniele , Colombo Alberto , Antinori Andrea , Girardi Enrico , Vaia Francesco , Maggi Fabrizio
Published: January 2023

With numbers of COVID-19 cases having substantially increased at the end of 2022 in China, some countries have started or expanded testing and genomic surveillance of travellers. We report screening results in Italy in late December 2022 of 556 flight passengers in provenance from two Chinese provinces. Among these passengers, 126 (22.7%) tested SARS-CoV-2 positive. Whole genome sequencing of 61 passengers’ positive samples revealed Omicron variants, notably sub-lineages BA.5.2.48, BF.7.14 and BQ.1.1, in line with data released from China.
Bədən tərbiyə və idman sahəsində inkişaf texnologiyaları
Authors: Huseynov Farhad J.
Published: January 2023

Müasir zamanın təlabatları bədən tərbiyəsi və idman sahəsində inkişafın və təhsilin yeni idarəetmə modellərinin qurulmasının vacibliyini tələb edir. Bunun üçün bir sıra ölkələrin aparıcı idarəetmə texnologiyaların istifadəsi və innovasiyalı təkliflərin tətbiqi sahəsində təcrübənin öyrənilməsinə ehtiyac vardir. Avropa ölkələrinin bədən tərbiyəsi və idman sahəsində əyalətlərdə inkişafın idarəetmə texnologiyaların məzmunu haqqında məlumatın əldə edilməsi maraq doğurur. Müsbət nəticə əldə edilən ölkələrin təcrübəsindən faydalanma və bizim ölkədə istifadə edilməsi bədən tərbiyəsi və idmanın inkişafına təsir göstərə bilər. İlk növbədə yeni texnologiyaların son nəticələrinin, modelinin quruluşunun öyrənilməsi və təhlil edilməsi yerli idarəetmə təcrübəsində istifadə etmək olar.
Kompüter elminin inkişaf perspektivləri
Authors: Kələntərli Nailə , Mazanova Səadət
Published: January 2023

Dünyada çox böyük həcmdə informasiya toplanıb, ancaq insanların çoxu öz psixoﬁziki imkanlarının məhdud olması və informasiyanı emal edən yeni informasiya texnologiyalarını tətbiq edə bilmədikləri üçün bu maddi nemətlərdən tam istifadə edə bilmirlər. Kompüter və çoxsaylı kompüterləri birləşdirən qlobal şəbəkələr bəşəriyyətin bütün inkişaf tarixi ərzində insanın intellektu- al imkanlarının ən qüvvətli gücləndiricilərinə çevrilir.
İdman testlərinin etibarlılığının yoxlanması
Authors: Shahla Valiyeva  , Aynel Veysalova
Published: January 2023

Tədqiqatda 100m məsafəyə qaçış zamanı testdən keçirilən 7 nəfər idmançının nəticələrinə əsasən, testin etibarlılığının qiymətləndirilməsi öz əksini tapmışdır. Bunun üçün, test aralarındakı məsafə bir həftə olmaqla iki dəfə keçirilir. Testin nəticələrinə əsasən etibarlılığın yoxlanması üçün korrelyasiya əmsalı hesablanır. Etibarlılıq üçün qiymətləndirmə cədvəli nəzərə alınaraq, aparılmış hesablamaların nəticəsi qiymətləndirilir.
Modernization of Islamic Education Learning Ahmad Tafsir Perspective
Authors: Muvid Muhamad Basyrul , Taufik Ahmad
Published: January 2023

This study aims to examine and analyze more deeply the idea of modernizing Islamic religious education learning in the style of Ahmad Tafsir. The research method used is literature by collecting various reference sources, books, articles, documents related to the topic of study. It can be concluded that the modernization of Islamic religious education learning from Ahmad Tafsir's perspective emphasizes collaboration and integration between spiritual, intellectual and moral intelligence. Considering that these three intelligences are the basic capital for graduates of Islamic religious education, so that they can actualize all their potential in the midst of community life that is supported by high morality and spirituality. Thus, all the abilities and talents of students who are forged during learning do not come out of the ethical values of the Islamic religion itself.
Consumo e distinção social no espaço digital
Authors: Castro Ana Lúcia de , Silva Marina Kuranaga
Published: January 2023

Partindo do pressuposto de que o consumo - como um dos principais modos pelos quais o habitus pode ser expressado - carrega uma dimensão distintiva, na medida em que indica fronteiras simbólicas e elos de pertença entre os grupos sociais, este artigo busca contribuir para a reflexão sobre algumas dinâmica de distinção na configuração social brasileira contemporânea. Para tanto, toma como universo empírico dois espaços recortados nas redes sociais: um grupo de Facebook relacionado à compra e venda de produtos na 25 de março, famosa rua de comércio popular na cidade de São Paulo, e o perfil no Instagram de uma digital influencer da área de moda e estilo, Maju Trindade.
Investigando a articulação entre objetos de aprendizagem, história da matemática e formação de professores por meio de levantamentos bibliográficos em plataformas nacionais e internacionais
Authors: Oliveira Gisele Pereira , Pereira Ana Carolina Costa
Published: January 2023

Esse artigo objetiva conhecer o cenário de investigação promovido pela articulação entre Tecnologias Digitais da Informação e Comunicação (TDIC), como Objetos de Aprendizagem (OA), História da Matemática (HM) e Formação de Professores, em plataformas bibliográficas de natureza nacional e internacional. Entre os ambientes pesquisados nacionalmente, identificamos a Biblioteca Digital Brasileira de Teses e Dissertações (BDTD) e o Catálogo de Teses e Dissertações da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), já os ambientes de natureza internacional, foram o Networked Digital Library of Theses and Dissertations (NDLTD) e JSTOR. O levantamento foi mediado através da pesquisa com o uso de determinadas palavras-chave/ descritores de busca, usando conectivos booleanos de interseção e critérios para refinamento. O percurso metodológico foi delineado a partir da primeira fase da metodologia Engenharia Didática, intitulada por Análises Preliminares, caracterizada pela realização de levantamentos bibliográficos que forneceram informações quanto a um determinado contexto de pesquisa. Entre os resultados, no filtro temporal de 2016 a 2022, coletamos dentre os critérios de tratar obrigatoriamente de OA e contemplar mais um dos outros dois descritores pontuados, de um total de 20.841 sem repetição de materiais e sem reduções por critérios, já com refinamentos obtemos 1.773 e, após análises previamente determinadas selecionamos cinco materiais, sendo quatro dissertações e uma tese, que se adequavam as orientações.  Desses cinco, todos faziam parte da esfera nacional, pois internacionalmente não foram encontrados nenhum que se adequasse. Por fim, observamos uma fragilidade de discussões científicas em relação a estudos que articulem as tecnologias de OA com a história da Matemática e a Formação de professores de Matemática no âmbito nacional e internacional.
Endometriosis as an Infectious Disease: Association with Chronic Endometritis
Authors: Kitaya Kotaro , Mihara Takako , Mihara Masaya
Published: January 2023

Objectives: Recent studies focus on immunological, infectious, and inflammatory aspects of endometriosis. Meanwhile, chronic endometritis (CE) is an immunological, infectious, and inflammatory disorder of the eutopic endometrium with unusual stromal plasmacyte infiltration. Mechanism: In this review article, we aimed to gain a better understanding of the relationships between endometriosis and CE. Findings in Brief: Accumulating evidence supports the idea that CE is associated with infertility of unknown etiology, repeated implantation failure in an in vitro fertilization-embryo transfer program, recurrent pregnancy loss, as well as several perinatal/neonatal complications. Endometrial biopsy/histopathologic examinations and/or hysteroscopy are required to make a definitive diagnosis of CE. Conclusions: While endometriosis has been long considered a cause of infertility, CE is also an emerging issue that may reduce fecundity in women of reproductive age. Endometriosis and CE share characteristics of endometrial proliferative nature. The potential relationships between these two diseases of the uterine lining warrant future studies.
Monitoring of Pregnancy-Induced Hypertension Syndrome Combined with Ultrasound Monitoring in Early Pregnancy to Prevent Chronic Hypertension with Preeclampsia
Authors: Xiao Songyuan , Liu Jinyu , Liu Bo , Yu Ling , Deng Yali , Zhang Wen , Nie Yanting , Lai Weisi , Liu Hongyu , Zhou Yang , Yu Li , Wen Ying , Zhou Bo , Zhong Yanhong , Xiao Lingyi , Ding Yiling , Peng Mei
Published: January 2023

Background: This study explored the guiding value of monitoring pregnancy-induced hypertension syndrome (MP) for blood hypercoagulability in combination with ultrasound monitoring of uterine artery blood flow in early pregnancy and fetal growth and development in the second and third trimesters, with the goal of preventing chronic hypertension with preeclampsia (PE) and its clinical effects. Methods: The medical records of 189 pregnant patients with chronic hypertension between June 2016 and June 2021 were retrospectively analyzed; among them, 98 constituted the intervention group. The intervention group received MP screening for blood hypercoagulability in combination with ultrasound monitoring of uterine artery blood flow in early pregnancy and fetal growth and development in the second and third trimesters of pregnancy. Those with abnormalities were given timely symptomatic (low-molecular-weight heparin with or without aspirin) and supportive treatment. The remaining 91 patients who did not receive timely monitoring and intervention constituted the control group. Fetal outcomes and PE rates were compared between groups. Results: The PE incidence in the intervention group was significantly lower than that in the control group (p < 0.01), and the premature delivery of low-birth-weight neonates, fetal loss and neonatal asphyxia incidences were also significantly lower in the intervention group than the control group (p < 0.05). Conclusions: MP screening for blood hypercoagulability combined with ultrasound monitoring of uterine artery blood flow can effectively prevent PE occurrence in pregnant patients with chronic hypertension and significantly improve fetal outcomes. Additionally, MP screening is noninvasive and easy to use at a low cost.
Alternative Chemotherapies: Angiotensin-Converting Enzyme Inhibitors Reduce Myeloid-Derived Suppressor Cells to Benefit Older Patients with Colorectal Cancer
Authors: Bueno Valquiria , Forones Nora Manoukian , Pawelec Graham
Published: January 2023

Older individuals are more likely to develop solid cancers, but at the same time are more sensitive to the side effects of chemotherapy. In addition, older adults are more likely to present with chronic diseases (comorbidities) and immunosenescence that may decrease immunosurveillance against cancer. Clinical outcomes for the older patient with cancer are different from the younger patient and require different research and treatment approaches. Thus, alternative therapeutic approaches tailored specifically to the older patients are required. Colorectal cancer (CRC) has a high incidence in older individuals and is the third leading cause of cancer death globally. Anti-hypertensives are used by a large proportion of older patients and some studies have pointed to a positive impact of angiotensin-converting enzyme inhibitors (ACEi) or angiotensin receptor blockers (ARB) on CRC outcomes. As we have previously shown in a mouse model, lung metastases express ACE and contain many infiltrating myeloid-derived suppressor cells (MDSC); particularly high levels of MDSC are also present in the blood of older patients with CRC and other cancers, and are associated with disease severity. In this Commentary, we hypothesize that one mechanism responsible for the positive impact of ACEi or ARB on the outcome of CRC is the modulation of myeloid cells contributing to their maturation to non-suppressive neutrophils/monocytes and diverting them away from retaining an immature MDSC phenotype.
Transcranial Direct Current Stimulation Improves Some Neurophysiological Parameters but not Clinical Outcomes after Severe Traumatic Brain Injury
Authors: Sun Weiming , Liu Guanxiu , Dong Xiangli , Yang Yang , Yu Guohua , Sun Xing , Feng Zhen , Ma Chaolin
Published: January 2023

Background: Disorders of consciousness (DOC) are one of the clinical hallmarks of severe traumatic brain injury (TBI). DOC impair patient life quality and increase the burden on their families and society. Methods: A double-blind, randomized, controlled clinical trial was conducted to determine the efficacy of routine rehabilitation combined with transcranial direct current stimulation (tDCS) in DOC patients after TBI. A total of 78 DOC patients were randomly divided after TBI into two groups: participants in the treatment group received routine rehabilitation combined with an active tDCS protocol. In contrast, participants in the control group received routine rehabilitation combined with a sham tDCS protocol. An anode was placed over the left dorsolateral prefrontal cortex and a cathode was placed over the right supraorbital area. The stimulation intensity was 2 mA. Both tDCS protocols lasted for eight consecutive weeks (20 minutes per day, six days per week). Patients were followed up for a further eight weeks. Glasgow Outcome Scale (GOS), Glasgow Coma Scale (GCS), brainstem auditory evoked potentials, somatosensory evoked potentials and electroencephalogram were measured at weeks zero, two, four, six, eight and sixteen from the start of tDCS. Results: Neither the GOS nor GCS scores differed significantly between the two groups, while brainstem auditory evoked potentials, somatosensory evoked potentials and electroencephalogram scores did. Conclusions: This study found that tDCS improves some neurophysiological parameters but not clinical outcomes of DOC patients after TBI. Clinical Trial Registration: Chinese Clinical Trial Registry, ChiCTR1800014808 (The version is V.1.0). Registered on February 7, 2018. http://www.chictr.org.cn/showproj.aspx?proj=25003.
Fibrinolytic Therapy in Purulent Pericarditis
Authors: Dybowska Małgorzata , Szturmowicz Monika , Lewandowska Katarzyna , Sobiecka Małgorzata , Tomkowski Witold
Published: January 2023

Purulent pericarditis (PP) is rare disease, and if left untreated, it is associated with very high mortality, nearly 100%. A considerable clinical problem due to PP is a very high probability of developing constrictive pericarditis (CP). Pericardial drainage is essential in the treatment of PP and should be performed urgently. The use of broad-spectrum antibiotic therapy is equally important. Unfortunately, fibrin deposits often create occulated spaces and reservoirs that reduce the penetration of antibiotics and their effectiveness. The rationale for the intrapericardial use of fibrinolytic drugs in PP is based on their ability to dissolve fibrin strands and collagen fibres, thus improving the penetration of antibiotics to the pericardial sac and lowering the risk of CP. The choice of the drug, as well as its dosage and the method of administration is still under debate. The authors of the article share their experiences and review current literature on this rare topic.
Revision of Clinical Pre-Test Probability Scores in Hospitalized Patients with Pulmonary Embolism and SARS-CoV-2 Infection
Authors: Meter Mijo , Barcot Ognjen , Jelicic Irena , Gavran Ivana , Skopljanac Ivan , Parcina Mate Zvonimir , Dolic Kresimir , Ivelja Mirela Pavicic
Published: January 2023

Background: The need for computed tomography pulmonary angiography (CTPA) to rule out pulmonary embolism (PE) is based on clinical scores in association with D-dimer measurements. PE is a recognized complication in patients with SARS-CoV-2 infection due to a pro-thrombotic state which may reduce the usefulness of preexisting pre-test probability scores. Aim: The purpose was to analyze new clinical and laboratory parameters while comparing existing and newly proposed scoring system for PE detection in hospitalized COVID-19 patients (HCP). Methods: We conducted a retrospective study of 270 consecutive HCPs who underwent CTPA due to suspected PE. The Modified Wells, Revised Geneva, Simplified Geneva, YEARS, 4-Level Pulmonary Embolism Clinical Probability Score (4PEPS), and PE rule-out criteria (PERC) scores were calculated and the area under the receiver operating characteristic curve (AuROC) was measured. Results: Overall incidence of PE among our study group of HCPs was 28.1%. The group of patients with PE had a significantly longer COVID-19 duration upon admission, at 10 vs 8 days, p = 0.006; higher D-dimer levels of 10.2 vs 5.3 μg/L, p < 0.001; and a larger proportion of underlying chronic kidney disease, at 16% vs 7%, p = 0.041. From already established scores, only 4PEPS and the modified Wells score reached statistical significance in detecting the difference between the HCP groups with or without PE. We proposed a new chronic kidney disease, D-dimers, 10 days of illness before admission (CDD-10) score consisting of the three aforementioned variables: C as chronic kidney disease (0.5 points if present), D as D-dimers (negative 1.5 points if normal, 2 points if over 10.0 μg/L), and D-10 as day-10 of illness carrying 2 points if lasting more than 10 days before admission or 1 point if longer than 8 days. The CDD-10 score ranged from –1.5 to 4.5 and had an AuROC of 0.672, p < 0.001 at cutoff value at 0.5 while 4PEPS score had an AuROC of 0.638 and Modified Wells score 0.611. The clinical probability of PE was low (0%) when the CDD-10 value was negative, moderate (24%) for CDD-10 ranging 0–2.5 and high (43%) when over 2.5. Conclusions: Better risk stratification is needed for HCPs who require CTPA for suspected PE. Our newly proposed CDD-10 score demonstrates the best accuracy in predicting PE in patients hospitalized for SARS-CoV-2 infection.
Cardiovascular Disease in Post-Acute COVID-19 Syndrome: A Comprehensive Review of Pathophysiology and Diagnosis Approach
Authors: Kusumawardhani Nuraini Yasmin , Putra Iwan Cahyo Santosa , Kamarullah William , Afrianti Rien , Pramudyo Miftah , Iqbal Mohammad , Prameswari Hawani Sasmaya , Achmad Chaerul , Tiksnadi Badai Bhatara , Akbar Mohammad Rizki
Published: January 2023

Long COVID or post-acute Coronavirus disease 2019 (COVID-19), a malady defined by the persistence of COVID-19 symptoms for weeks or even months, is expected to affect the lives of millions of individuals worldwide significantly. Cardiopulmonary symptoms such as chest discomfort, shortness of breath, fatigue, and autonomic manifestations such as postural orthostatic tachycardia syndrome, and arrhythmias are prevalent and widely recognized. A variety of cardiovascular problems, including myocardial inflammation, myocardial infarction, ventricular dysfunction, and endothelial dysfunction, have been described in individuals following the initial acute phase. With over 10,000 published publications on COVID-19 and the cardiovascular system, presenting an unbiased thorough analysis of how SARS-CoV-2 affects the system is essentially challenging. This review will provide an overview of frequent cardiovascular manifestations, emphasizing consequences, proposed pathophysiology, and clinical diagnostic manifestation strategy.
MUTU FISIK BEBERAPA SEGMEN BERAS: SUBSIDI, NON-SUBSIDI DAN IMPOR
Authors: Munarso S Joni , Kailaku Sari Intan , Indriyani Rita
Published: January 2023

Indonesia merupakan salah satu negara dengan konsumsi beras tinggi, diikuti pertumbuhan penduduk yang tinggi, sehingga beras menjadi komoditas strategis yang sangat menentukan ketahanan pangan nasional. Kualitas dan harga beras selalu ditinjau kembali untuk melindungi hak konsumen. Peraturan Menteri Pertanian RI Nomor 31 Tahun 2017 memutuskan tentang Kelas Mutu Beras dengan dasar perubahan Standar Nasional Indonesia 6128 tahun 2015 tentang Beras. Tujuan dari penelitian adalah mengkaji mutu fisik dari beberapa jenis beras menggunakan standar Permentan 31/2017 dan SNI 6128:2015. Sampel yang digunakan terdiri dari 3 (tiga) jenis beras, yaitu beras bersubsidi Pemerintah (Beras sejahtera, dua sampel), beras non-subsidi yang umum dikonsumsi masyarakat (varietas Ciherang, dua sampel), dan beras impor (asal Jepang, satu sampel). Karakteristik fisik yang diamati antara lain derajat sosoh, butir kepala, butir patah, butir menir, butir merah, butir kuning, butir kapur, butir gabah dan benda asing, ukuran dan bentuk butir, derajat putih dan translucency. Pemilihan sampel beras mewakili tiga segmen konsumen dan kelompok harga yang berbeda, yaitu harga tinggi (konsumen menengah ke atas), harga menengah (konsumen menengah) dan harga rendah (penerima bantuan dari program Beras Sejahtera). Parameter yang diamati ditentukan berdasarkan SNI 6128:2015 dan Permentan 31/2017. Hasil pengujian dianalisis dengan statistik deskriptif. Nilai rataan mutu fisik kemudian diklasifikasikan untuk menentukan kelas mutu beras.  Berdasarkan hasil analisis mutu fisik, beras impor dan beras non-subsidi yang diambil dari Sumedang memiliki kelas mutu Premium, Beras non-subsidi yang diperoleh dari Karawang umumnya memiliki mutu Medium (Permentan 31/2017) atau Medium 1 (SNI 6128:2015), sedangkan beras bersubsidi hampir seluruhnya tidak memenuhi syarat berdasarkan kedua standar.