bluuebunny/crossref_metadata_2025 huggingface dataset:
Applied epidemiology of the pathogens involved in porcine respiratory disease complex
Authors: Rose Nicolas
Published: November 2018

Swine influenza A viruses (swIAv), porcine reproductive and respiratory syndrome virus (PRRSV), porcine circovirus type 2 (PCV2), Mycoplasma hyopneumoniae and Actinobacillus pleuropneumoniae are the main infectious agents involved in porcine respiratory disease complex (PRDC). Their conditions for spread and persistence in pig populations are mainly related to host or pathogen interactions and the features of pig population dynamics. The resulting endemic persistence in pig farms leads to complex interactions between those viruses and bacteria governing the severity of PRDC and the ability to control the clinical consequences in pig farms. Implications of the specific epidemiology of these infectious agents are discussed in this paper in the perspective of potential strategies for a better control.
BEVA report: making the business enjoyable
Authors: Mitchell Colin
Published: November 2018

Introduction:

In additon to the usual clinical streams, this year's BEVA conference included five sessions on the non-clinical side of equine practice: the ‘business’ aspects of being an equine vet, covering finance, human resource management, marketing, corporatisation and ‘thriving in practice’ — all being important aspects of modern equine veterinary practice, as the speakers explained.
Overcoming barriers to implementing targeted worming strategies
Authors: Rendle David
Published: November 2018

Equine practices cannot fail to be aware of the need to implement sustainable parasite control strategies, yet engagement with practice-led targeted worming plans remains poor and many owners persist with interval dosing strategies or they administer anthelmintics in a haphazard manner. Veterinary practices should be in a position to be able to offer a better service to their clients than any other provider, if they have the motivation to do so. Practices that do use worming plans to their advantage can see benefits from increased anthelmintic and laboratory test sales, improved uptake of other packaged services and greater client engagement with the practice.
Managing acute colitis in the adult horse
Authors: Johns Imogen
Published: November 2018

Management of adult horses with acute colitis is challenging, as intensive therapy is often required, the causative agents are frequently elusive, complications such as laminitis are common and the prognosis can be poor. The most commonly identified causes include infectious causes such as salmonellosis and clostridiosis, parasitic causes (larval cyathostominosis) and non-infectious causes such as antimicrobial administration and right dorsal colitis. Testing for infectious agents, in particular Salmonella spp., should always be performed, due to the risk of disease transmission to other animals and to people. While specific therapies exist for some conditions, supportive therapy, particularly fluid therapy and anti-inflammatory therapy, are key. The prognosis is variable, with morbidities such as laminitis often affecting the likelihood of a positive long-term outcome.
Ultrasonography of the hock
Authors: Smith Roger KW , Cauvin Eddy
Published: November 2018

The hock is a complex joint comprising a number of low-motion joints and a single high-motion joint, together with a large number of soft tissues consisting of ligaments and tendons with their own tendon sheaths and bursae. The hock, including the proximal metatarsal region, is considered the most common site for hindlimb lameness and so ultrasound offers significant diagnostic benefit for this area. The indications for ultrasound examination of the hock are soft tissue swellings in the region of the hock (including effusions of the tarsoscrural joint, tendon sheaths and bursae), wounds including detection of foreign bodies, and lameness localised to the tarsal region. This article describes the ultrasonographic technique and normal ultrasonographic anatomy, and shows examples of the most common pathologies encountered.
Clinical Audit of Gabapentin use in a Mental Health Hospital in Qatar
Authors: Elbakary Nervana , Hashem Hazem
Published: November 2018

Bakground: Gabapentin was approved by FDA for the treatment of epilepsy, and as an analgesic for post-herpetic neuralgia (PHN). Gabapentin has been prescribed off-label for a wide range of disorders. Off-label use of gabapentin has been estimated to range from 83 to 95% of all its use. In the last few years, gabapentin has been becoming dispensed extensively for appropriate and inappropriate uses; meanwhile, drug-monitoring agencies have warned for potential abuse liabilities associated with gabapentin. The principal population at risk for addiction consists of patients with history of substance use disorders (SUD), mostly pregabalin and opioids. Purpose: To audit the appropriate use of gabapentin among a cohort of drug users, followed by subgroup analysis to determine the likelihood of drug abuse, misuse and/or diversion. Results: A total of 76 patients were included in the study. 99% of candidates used Gabapentin for off label indications, 30% for managing of behavioral symptoms related to dementia (BPSD). 27%, of the cohort used the medication had a confirmed history of substance-use disorder (SUD). One patient found to receive an inappropriate dose with regard to Creatine clearance Crcl. Conclusion: The data analysis has revealed that almost all gabapentin use in this setting was for off-label indications. Without placing limitations on the prescribing of this medication, it is expected that misuse of it by patients will continue to upsurge. This study highlights the need to standardize a hospital protocol for Gabapentin use within this facility, especially among patients with a history of substance- use disorder.
Идентификация и образ адресата в интернет-соболезнованиях
Authors: Narloch Andrzej
Published: November 2018

An internet condolence letter has become a new form of communication in special circumstances. The selection of appropriate vocabulary plays a vital role in writing internet condolence letters as it is indirectly connected with expressing sympathy, support and understanding. In addition, the form of addressing the recipient often determines the right reception of a condolence letter. A recipient is identified in apostrophes in many ways. His or her nationality is emphasized most frequently. Also, ethnicity and social relationships are quite often indicated. Very emotional apostrophes directed to the dead have also been found in the analyzed material. Each kind of identification requires using suitable means of expression. Many of them contain additional emotive language. The analyzed apostrophes are very emotional and full of positive evaluative expressions. All the same, there are also many official, almost pompous constructions.
An assessment of natural language robustness and how it relates to natural language sustainability: a fuzzy ecological approach to the lives of natural languages
Authors: Puppel Stanisław
Published: November 2018

All living natural languages may be characterized in terms of their overall ‘robustness’. The concept may be defined as relating directly to the health/vitality /wellbeing (i.e. sustainability) of these languages. In the paper, an attempt is made to further define the concept in terms of a set of parameters as well as to show that natural languages differ as to the degree of their overall robustness.
О категоризации понятия „земля” в семантико-культуроло- гическом аспекте (на материале русских и польских фразеологизмов с лексическим компонентом „земля”/„ziemia”)
Authors: Sitarski Andrzej
Published: November 2018

The author of this article assumes that culturological and semantic studies of a language allow one to achieve particular results by drawing attention to linguistics, which plays a vital part in the semantic interpretation of all linguistic fields (maybe excluding phonetics). The meaning of linguistic signs itself conveys fundamental information about the picture of life and mentality that is typical of a given linguistic, cultural and ethnic group. Taking into consideration a cultural and semantic paradigm when analyzing Russian and Polish idioms with the lexical component земля/ziemia, the author draws a conclusion that the interpretation of the concept of land in the studied idioms is deeply anthropocentric. It also reveals the axiological attitude of Poles and Russians toward land.
Новые требования к обучению русскому образцовому произношению польских студентов-русистов, изучающих русский язык с нулевого уровня
Authors: Dziewanowska Dorota
Published: November 2018

This article is an attempt to show new ways of teaching model Russian pronunciation to Polish students of Russian language and literature who only begin to learn Russian. The author of the article claims that groups of beginners should not only be taught phonetics during the first several weeks of studies in the form of intensive courses of articulation and intonation. The process of forming correct pronunciation habits in these groups should carefully follow the principle of complexity involved in acquiring speaking skills.
O niektórych meandrach w rusycystyce zachodnioeuropejskiej
Authors: Figarski Władysław
Published: November 2018

The article focuses on the complex process of development and the actual state of contemporary Russian studies in selected countries of Western Europe. The author describes this hard and thorny path of development which, like a maze, is intricate and ambiguous as well as full of difficulties and obstacles, and he analyzes the condition of Russian studies in England, France, Italy and Spain.
Размышления о грамматике в обучении иностранным языкам
Authors: Jelínek Stanislav
Published: November 2018

The article describes some changes in views on the role and acquisition of grammar as a set of forms and syntactic structures and as a system of rules and paradigms in foreign language teaching and learning. An essential part of the article is devoted to explaining key phases that are used when teaching and learning Russian grammar, mainly by presenting various exercises and focusing on the function of forms and structures in communication. This process is presented based on the example of a textbook for Czech learners of the contemporary Russian language.
Kształtowanie nawyków językowych w procesie glottodydaktycznym (aspekt ewolucyjno-antropocentryczny)
Authors: Józefiak Sylwester
Published: November 2018

This paper characterizes the theory and practice of developing language habits. The author describes some of the ways of forming habits by using glottodidactic methods such as: audio-lingual, cognitive and communicative. The results of the analysis show that the development of language habits should take place in repetitive informal situations, in which people use a foreign language in accordance with their intentions.
Komunikator ustny jako performer właściwie ułożony i właściwie licencjonowany w przestrzeni publicznej
Authors: Puppel Stanisław
Published: November 2018

The present essay expresses the view that a human communicating agentwho performs orally in the public space must be properly communicatively aligned and properly licensed in order to achieve communicative success. Communicative alignment and communicative licensing are manifestations of the principle of communicative alignment and the principle of communicative licensing, respectively. The two principles are assumed to act synergistically in both successful and unsuccessful communicative practices.
Названия членов русских политических партий и их отражение в польской прессе
Authors: Jóźwiak Jolanta
Published: November 2018

The aim of this paper is to present the word formation strategies that areused to create the names of the members of Russian political parties. In the second part of the article the author focuses on difficulties associated with introducing these names into the Polish press with regard to their cultural connotations.
Der Bau der neuen Nationalbibliothek von Katar
Authors: Lux Claudia
Published: November 2018

Die neue Nationalbibliothek von Katar wurde vom niederländischen Architekten Rem Koolhaas entworfen und am 16. April 2018 eröffnet. Die Bibliothek hat nicht nur eine außergewöhnliche äußere Form, sie hat vor allem innen eine Plaza, die über 20 000 Quadratmeter groß ist und neben den Terrassen mit Büchern und den Vitrinen in der historischen Sammlung eine Vielzahl anregender Arbeitsplätze und Besprechungsbereiche besitzt. Auch eine Kinderbibliothek und viele neuartige Innovationsräume machen diese Bibliothek zu einem Erlebnis für jedermann.
Zwischen Tradition und Moderne: Der Bibliotheksneubau der Universität Marburg
Authors: Wolff-Wölk Andrea , Rohde Ilona , Reuter Jutta
Published: November 2018

Der Bibliotheksneubau der Philipps-Universität Marburg wurde im April 2018 eröffnet. Die neue Bibliothek bildet das „Herzstück“ des neu geschaffenen Campus Firmanei der Philipps-Universität, wobei die moderne Architektur die städtebaulichen Besonderheiten der historischen Universitätsstadt in besonderer Weise inszeniert. Raum- und Bibliothekskonzept wurden eng aufeinander abgestimmt. Dabei sollte die Bibliothek nicht nur räumlicher Mittelpunkt des Campus Firmanei sein, sondern als Lern- und Kommunikationsort eine zentrale Rolle für Studium, Forschung und Lehre an der Philipps-Universität spielen.
Das Netzwerk universitärer Münzsammlungen in Deutschland (NUMiD): Neue Perspektiven der Digitalisierung in der Numismatik
Authors: Dahmen Karsten , Martin Katharina , Weisser Bernhard , Wienand Johannes
Published: November 2018

Im Netzwerk universitärer Münzsammlungen in Deutschland (NUMiD) haben sich über 30 Universitäten zusammengeschlossen, um zusammen mit dem Münzkabinett der Staatlichen Museen zu Berlin als außeruniversitärem Projektpartner und mit substanzieller Förderung durch das BMBF einen deutschlandweiten Forschungs- und Digitalisierungsverbund numismatischer Sammlungen zu bilden. Erstmals in der Geschichte der universitären Münzsammlungen wird im Verbund eine gemeinsame, zusammen genutzte und nachhaltig nutzbare Wissensbasis für sammlungsbezogene numismatische Forschung, Lehre und Vermittlung geschaffen. Das Ziel besteht darin, ein Modell für die Zukunft universitärer Münzsammlungen zu etablieren, das den beteiligten Einrichtungen auch in Zeiten eines tiefgreifenden Wandels der Universitätslandschaft ermöglicht, über die bloße Bewahrung der kulturellen Werte ihrer Sammlungsbestände hinaus eine neue Ära der Forschung und Lehre an und mit den universitären Münzsammlungen einzuläuten, die einzelnen Sammlungen in ihrer nationalen wie internationalen Bedeutung nachhaltig zu stärken und der universitären Numismatik neue Impulse zu verleihen.
Primo gegen Google Scholar – benutzerfreundliches Discovery 10 Jahre später
Authors: Beck Cyrus
Published: November 2018

Wissenschaftliche Bibliotheken stehen seit zehn Jahren vor der Frage, ob sie für die Vermittlung ihrer Bestände Discovery-Systeme oder Internet-Suchmaschinen wie Google Scholar einsetzen sollen. Ein Vergleich des Discovery-Systems Primo des Anbieters Ex Libris mit Google Scholar zeigt, dass Primo eine bessere Usability bietet, indem es summa summarum einfacher zu bedienen ist sowie relevantere und vielfältigere Treffer liefert.
On the subsistence types of the Xiantouling Culture
Authors: Chen Weiju
Published: November 2018

The Xiantouling Culture featured sand dune sites and shell midden (kitchen midden) sites. Through an analysis of the faunal and floral remains and tools unearthed from these sites, with the relevant unearthed pottery wares and paleo-environmental research results taken into account, it can be evidenced that the subsistence types of these sites were mainly plant gathering supplemented by fishing and hunting, instead of relying on marine resources. The subsistence type of the sand dune sites was mainly plant gathering and occasionally rice gathering or farming; that of the earlier kitchen madden sites was gathering freshwater shells, and that of the later ones was more relying on marine resources. From the late phase of Xiantouling Culture, the archaeological cultures in the coastal areas of southeastern China began to utilize marine resources in a large scale.
On the provenance study method of the archaeological relics based on styles and distributions
Authors: Bai Yunxiang
Published: November 2018

The provenance study of the artificial products among the archaeological artifacts is an important content of the archaeological research. The relevant methods applied in the academic field at present all have their effectiveness as well as limitations. Focusing on the practices and experiences in the study on the bronze mirror casting industry in the Linzi City Site of the Qi State in Shandong, this paper puts forward the provenance estimation method based on the styles and distributions of the artificial products, which suggests that different production places (origins) produced different local styles, while the products made in each origin were circulated in the zone with the origin as the center. Therefore, according to the spatial distribution of the artificial products, the location with the most densely distributed products with this style could be inferred as their origin. Then, this paper discussed the identification and summarization of the “origin style”, the observation and analyses of the regional distribution and the estimation and confirmation of the origins, the scope of application of this method and other relevant issues in the application of this provenance estimation method.
Maitreya statues in the Southern Dynasties and the incarnation of Fu Dashi as Maitreya
Authors: Li Yuqun
Published: November 2018

In the 5th and 6th centuries, the belief of the descent of Maitreya was very popular in the Jiangnan area, the Longhua Monastery worshipping the statue of Maitreya as Buddha was flourishing, and the Longhuahui (Maitreya’s preach assembly under the dragon-flower tree, aka Sri Lankan ironwood) was also once prospering. The Maitreya figures of the Southern Dynasties in the Jiangnan area are seen in the cliff niches at Baoxiang Monastery in Xinchang County, Zhejiang and the Mount Qixia Grottoes in Nanjing, Jiangsu; in Sichuan area, the Maitreya figures of the Southern Dynasties are seen on the votive stele made by Monk Xuansong in Maoxian County and the Maitreya statue made by Monk Fahai found at Xi’an Road in Chengdu. Fu Dashi (497–569 CE), a devout lay Buddhist native to Dongyang District of the Southern Dynasties, announced himself as the incarnation of Maitreya to attract believers, and invented the zhuanlun jingzang (rotating Buddhist scripture library).
A preliminary research on the burials of the Mongol Khanate period and Yuan Dynasty in northern area
Authors: Dong Xinlin
Published: November 2018

Based on the periodization and zoning of the burials of the Mongol Khanate period and the Yuan Dynasty and referring to the textual materials of the stone tablets and epitaphs and the different funeral customs, this paper classified these burials into the burials of the Mongol people, the burials of the “Mongolized” people, the burials of the “Semu ren (Miscellaneous aliens)” and that of the Han people, and preliminarily summarized the features of the funeral customs of the tombs of the Mongol people, provided references for identifying the tombs of the Mongol Khanate period and the Yuan Dynasty without inscriptions.
On the generalized absolute convergence of Fourier series
Authors: Meskhia Rusudan
Published: November 2018

In the present paper the sufficient conditions are obtained for the generalized r-absolute convergence (

0
<
r
<
2

{0<r<2}

) of the single Fourier trigonometric series in terms of the modulus of δ-variation of a function.
It is proved that these conditions are unimprovable in a certain sense.
The classical results of Berstein, Szasz, Zygmund and others, related to the absolute convergence of single trigonometric Fourier series, were previously generalized by [L. Gogoladze and R. Meskhia,
On the absolute convergence of trigonometric Fourier series,
Proc. A. Razmadze Math. Inst. 141 2006, 29–40].
New Impressions in Interaction Design: A Task Taxonomy for Elastic Displays
Authors: Kammer Dietrich , Müller Mathias , Wojdziak Jan , Franke Ingmar S.
Published: November 2018

Novel shape-changing interfaces promise to provide a rich haptic experience for human-computer interaction. As a specific instance of shape-changing interfaces, Elastic Displays provide large interaction surfaces that can be temporally deformed using force-touch. The unique property of these displays is that they automatically return to their initial flat state. Recently, several review and position papers have stimulated a discussion towards consolidating the knowledge about shape-changing interfaces. The knowledge about Elastic Displays is similarly scattered across multiple publications from recent years. This paper contributes a task taxonomy based on productive uses of Elastic Displays found in literature, on the web, and in our interaction lab. This taxonomy emphasizes tasks, but also encompasses general aspects regarding content types, visualization technology, and interaction styles. All aspects of the taxonomy are illustrated using case studies from literature.
Time and Tragedy in Beth Henley’s The Jacksonian
Authors: Foster Verna A.
Published: November 2018

In The Jacksonian, an autobiographical play set in Mississippi in 1964, Beth Henley filters a tragic action based on the Aristotelian model through the non-linear memory of Rosy, the play’s narrator and choric figure, as she tries not to remember that her father has killed her mother. Rosy’s father, Bill—a Girardian scapegoat figure contaminated by the racist violence of the community he lives in—is the protagonist of the tragic action. But Henley focuses on its effect on Rosy. A tragic event can occur only in progressive chronological time, but by circling around the murder in her memory, Rosy creates temporal stasis until finally the pressure of denial becomes unbearable and the murder takes place. Tragic inevitability is displaced from the formally tragic action to Rosy’s memory of it. A comparison of The Jacksonian with other dramas that incorporate tragic experience within a non-linear time scheme suggests that only in memory plays can tragedy as a genre exist in non-linear time.
Acetylcholinesterase activity and bone biochemical markers in premature and full-term neonates
Authors: Dokos Charalampos , Tsakalidis Christos , Manaridou Kyriakoula , Koliakos George
Published: November 2018

Background

Almost 30% of the premature infants have low body weight and bone mineral density due to prematurity. There is no consensus of screening premature neonates for metabolic bone disease; therefore, it is important to investigate the use of bone biochemical parameters. Latest studies involved the activity of acetylcholinesterase as a mediator in bone remodeling. It is hypothesized that there is a possible correlation of bone biochemical biomarkers and acetylcholinesterase (AChE) activity in premature infants.

Methods

We studied 50 neonates (26 preterm with gestational age <32 weeks, 24 full-term). Clinical data (sex, gestational week) and anthropometric parameters (body weight) were recorded. We directly measured the bone biochemical markers in serum such as alkaline phosphatase (ALP), calcium (Ca), phosphorus (P), magnesium (Mg) and parathyroid hormone (PTH). In addition, we measured the AChE activity.

Results

ALP and parathyroid hormone levels were higher, but Ca, P and AChE were lower in premature neonates group compared with full-term ones. There is a significant positive correlation of gestational age with body weight, Ca and AChE. A significant negative correlation was observed for ALP and PTH with gestational age.

Conclusions

We found a gestational age-related increase of AChE activity. There were significant relationships between AChE activity with P and PTH.
Branding and communities: The normative dimension
Authors: Sørensen Bent
Published: November 2018

The article offers a Peircean “glimpse” of the normativity of the brand community. The theoretical framework will primarily be Peirceʼs semiotics, while also adding a few insights from his thoughts on (ethical) normativity and the formal conditions of community. Firstly, I will describe the brand community as a semiotic entity based on three inter-related conditions involving “inner” and “outer” processes of branding where “inner process” is where we find the most explicit dynamics of the brand community related to a “common consent of meaning” and a “sense of community.” Secondly, I will try to describe how values and ideals can be understood within the brand community, including how the values and ideals (semiotically) transfer normative meanings by bringing together brands with consumers and thereby affect their feelings, acts, and thoughts so that they can become members within a brand community.
Identification of immune-related genes in thymus of breast cancer mouse model exposed to different calorie restriction
Authors: Omeroglu Ulu Zehra , Ulu Salih , Dogan Soner , Guvenc Tuna Bilge , Ozdemir Ozgenturk Nehir
Published: November 2018

Introduction

In the present study, RNA sequencing-mediated transcriptome analysis was performed in order to elucidate the molecular mechanisms of the immune response for different types of calorie restriction (CR) application using MMTV-TGF-α breast cancer mouse model.

Methods

Animals were applied to three different dietary regiments; ad libitum (AL), chronic calorie restriction (CCR) and intermittent calorie restriction (ICR). Using thymus tissues, 6091 differentially expressed genes (DEGs) were identified in three dietary groups. After clustering of total of 6091 DEGs using Gene Ontology (GO) categories, a total of 400 genes were identified to be involved in immune system process (GO:0002376) GO categories. KEGG pathway and gene co-expression network analysis of these immune-related DEGs were done using String database. The results were confirmed with measuring mRNA expression levels of four selected immune-related DEGs genes (Casp3, Thy1, IL-16 and CD4) using quantitative real-time PCR (qPCR).

Results

The expression levels of immune-related genes were different in three RNA-seq data.

Conclusion

The results provide useful information to investigate the immune-related transcriptional profiling in thymus tissue of breast cancer mouse model applied to two different types of CR and to identify the specific functional immune related genes in response to CR during cancer development.
Effect of myricetin on primary open-angle glaucoma
Authors: Yang Qing , Li Ying , Luo Lin
Published: November 2018

Background

Primary open angle glaucoma (POAG) is the most common form of glaucoma, with a multifactorial etiology that results in retinal ganglion cell death and loss of vision. In this study, we assessed the effects of myricetin on the trabecular meshwork cells in POAG.

Methods

In thein-vivomodel, glaucoma was induced in Sprague-Dawley rats by injecting hyaluronic acid into the anterior chamber of the eye (every week for six-weeks). Treatment group rats were administered myricetin (25, 50 or 100 mg/ kg body weight via oral gavage) each day for of six weeks.

Results

POAG TM cells exposed to myricetin (25, 50 or 100 μM) exhibited significantly lowered reactive oxidative species (ROS) levels and lipid peroxidation products. The expressions of transforming growth factors (TGFβ1/β2), vascular endothelial growth factor, and senescence markers (senescence associated-β-galactosidase, cyclin-dependent kinase inhibitors-p16 and p21) were substantially down-regulated in POAG TM cells exposed to myricetin. Myricetin effectively prevented IOP elevation in glaucoma-induced rats and decreased inflammatory cytokines (IL-1α, IL-1β, IL-6, Il-8, TNF-α) in the aqueous humor and POAG TM cells of glaucoma-induced rats.

Conclusion

The observations of the study illustrate the protective effects of myricetin in glaucomatous TM cells.
Tuberous sclerosis complex: Clinical spectrum and epilepsy: A retrospective chart review study
Authors: Almobarak Sulaiman , Almuhaizea Mohammad , Abukhaled Musaad , Alyamani Suad , Dabbagh Omar , Chedrawi Aziza , Khan Sameena , Aldhalaan Hesham
Published: November 2018

Tuberous sclerosis complex (TSC) is an autosomal dominant genetic neurocutaneous disorder, with heterogeneous manifestations. We aimed to review the clinical presentation of TSC and its association with epilepsy among Saudi population. This was a retrospective chart review study of 88 patients diagnosed with TSC with or without epilepsy. In 38.6% of patients, symptoms began before 1 year of age. The most frequent initial manifestations of TSC were new onset of seizures (68.2%), skin manifestations (46.6%) and development delay (23.9%). During the evolution of the disease 65.9% had epilepsy, 17% facial angiofibromas, 13.6% Shagreen patch, 18.2% heart rhabdomyomas and 12.5% retinal hamartomas. The genetic study for TSC diagnosis was done for 44 patients, 42 (95,4%) of them were genetically confirmed, for whom 13 patients had TSC1 mutation (29.5%), 29 patients were carrying TSC2 gene mutation (65.9%), Genetic test for TSC 1 and TSC 2 were negative for 2 patients (4.5%) despite positive gene mutation in their relative with TSC. The most common manifestations were central nervous system (predominantly epilepsy) and dermatological manifestations. Most of the patients develop epilepsy with multiple seizure types. TSC 2 mutation is more common than TSC 1 mutation.
Direct Tension Test for Characterization of Tensile Behavior of Ultra-High Performance Concrete
Authors: Zhou Zhidong , Qiao Pizhong
Published: November 2018

Ultra-high performance concrete (UHPC) is characterized by its superior strength, ductility, durability, and particularly its unique post-cracking performance in tension. Dog-bone–shaped specimens are widely used for determination of the tensile behavior of UHPC, but there is no standard test method or specimen design for the characterization of tensile behavior. In this study, an evolving strategy on designing a direct tension test (DTT) specimen is first conducted using numerical finite element analysis. Seven series of DTT specimens made of UHPC and with well-designed dimensions to avoid local stress concentration are then tested experimentally. Results indicate that the post-cracking localization within the gauge measurement region is guaranteed, and the DTT specimen is capable of fully capturing tensile stress–strain responses of UHPC. An idealized constitutive model with three linear phases is proposed to fit the experimental data and thus characterize the linear elastic, strain-hardening, and strain-softening behavior of UHPC in tension. Four tensile material parameters extracted from the experimental stress–strain curves are implemented in the idealized constitutive model from which the multi-phase responses of UHPC in tension are reconstructed. It is found that most tensile material parameters extracted from experimental stress–strain curves, including tensile strength, modulus of elasticity, and dissipated energy, increase with the increased volume fraction of steel fibers, curing age, and displacement loading rate, while the strain capacity at the first cracking remains nearly constant. The DTT specimen developed can be used effectively to characterize the tensile behavior of ductile fiber-reinforced cementitious materials.
Use of the ClearSight® System for Continuous Noninvasive Hemodynamic Monitoring during Heart Valve Interventions: Review of the Literature and Single-Site Experience
Authors: Gellert George , Bramlage Peter
Published: November 2018

During interventional and structural cardiology procedures, such as mitral valve (MitraClip, BMV), aortic valve (TAVR, BAV), tricuspid valve (MitraClip), left atrial appendage (Watchman, Lariat), atrial septum (ASD/PFO closure), and coronary artery intervention (high-risk PCI), among others, patients are at a high risk of hemodynamic instability and require continuous monitoring. This is conventionally achieved through arterial catheterization and transpulmonary thermodilution. However, such invasive techniques are time-consuming and have been associated with steep learning curves, vascular complications, and increased risk of infection. In line with the ongoing simplification and improvement of the catheter-based valve intervention, it is logical to investigate the effectiveness of continuous noninvasive hemodynamic monitoring in this setting. Over the last 2 years, our team has performed over 400 valve procedures with continuous hemodynamic monitoring via the noninvasive ClearSight system. This system is based on a finger-cuff and automated volume-clamp technology integrated into a simplified clinical platform (EV1000 NI). Although current evidence suggests that the technology results in slight differences in arterial pressure (AP) and cardiac output (CO) relative to the current, commercially available, invasive approaches, we have found the bias to be acceptable. Both the noninvasive and the invasive approaches have the same percentage of error when compared to the true CO and provide beat-by-beat detection of acute changes facilitating shorter response times. In addition to AP and CO, the system provides up-to-date information on stroke volume (SV), stroke volume variation (SVV), and systemic vascular resistance, which can be useful in aiding decision-making and provide better postoperative outcomes, such as shorter length of stay (LOS), decreased postoperative infection, decreased postoperative arrhythmia, decreased postoperative renal failure, decreased postoperative congestive heart failure (CHF), and decreased readmission. Additionally, the simplicity of the system setup has translated into a time saving of up to 3 hours per day, allowing one team to perform an additional 2 to 3 valve interventions without moving rooms. Moving forward, a formal study comparing patient outcomes and cost-effectiveness between invasive and noninvasive hemodynamic monitoring techniques in valve replacement would be insightful.
Repeated Percutaneous Treatment of Massive Hepatic Cystic Echinococcosis in a Child
Authors: Balen Topić Mirjana , Skuhala Tomislava , Desnica Boško , Višković Klaudija , Drinković Martin
Published: November 2018

Because of mostly asymptomatic cyst growth and often-neglected nonspecific low-grade symptoms, many cases of cystic echinococcosis (CE) caused by Echinococcus granulosus in the pediatric population are diagnosed at school age, in an advanced and even complicated stage. In 2003, after 5 months of intermittent dull upper-right abdominal pain and nausea, a 13-year-old boy was diagnosed with massive liver CE, with ∼20 round-shaped double-walled medium-sized infective cysts, which permeated the whole liver. Because of their wide distribution across the liver tissue and the risky superficial position of some cysts, liver transplantation emerged as the optimal therapeutic option. Despite being described as only an exceptionally used method for CE, we subjected our patient on 4 occasions to a radiofrequency energy thermoablation (RFT) procedure similar to the one used for malignant neoplasms. In total, 9 superficially situated cysts were initially treated with RFT by using a 14-gauge outer needle and a temperature of 70°C for 8 minutes per cyst, and the remaining cysts were treated with the puncture-aspiration-instillation-reaspiration procedure, along with albendazole (15 mg/kg per day) therapy, for a period of 20 months. After 2 years of follow-up, 4 residual small-sized semisolidified cysts were seen in the liver, and the patient showed no signs of relapse. Although not routinely used, RFT, along with puncture-aspiration-instillation-reaspiration and prolonged albendazole therapy, has shown good tolerability and long-term efficacy in the treatment of multiple infective CE, which could suggest the usefulness of the RFT method beyond salvage situations in pediatric patients.
Los procesos de socialización de docentes de inglés del Programa Nacional de Inglés para educación básica en las primarias públicas de Baja California
Authors: Márquez-Palazuelos Ma. del Carmen Enriqueta , Villezcas Vicki Lynn
Published: November 2018

El presente estudio busca conocer los procesos de socialización del personal docente que labora en el Programa Nacional de Inglés a nivel primaria y preescolar en Ensenada Baja California, México, para identificar, por un lado, la construcción de la identidad docente desde un enfoque socio pedagógico y; por otro, dar cuenta del contexto en el cual se encuentra inmerso para así contribuir al diálogo en apoyo a acciones que mejoren su entorno. Nuestro propósito no es solo generalizar sobre la construcción de identidades, sino también profundizar sobre el proceso que experimentan docentes que trabajan en el programa. Para enmarcar esta información se realizó un estudio cualitativo con orientación a estudio de caso. Los datos fueron recolectados a través de entrevistas semiestructuradas a un grupo de sujetos clave utilizando el método de análisis por categorías para organizar y concretar los resultados. La intervención circunscribe dos tipos de docentes; aquel grupo que cuenta con una formación pedagógica base, producto de su paso por programas formales de instrucción a nivel de universidad y, otros grupos que obtuvieron su trabajo como docentes por el manejo del inglés o su pertenencia al sistema educativo. También es significativa la manifestación de una falta de inducción al programa para su ingreso al contexto escolar, la precariedad de las condiciones laborales, la falta de apoyo para la capacitación pedagógica y el poco reconocimiento de la imagen del personal docente de lenguas por la sociedad.
La profesión de Turismo Ecológico en la Universidad de Costa Rica: Un análisis desde la perspectiva de su población graduada
Authors: Núñez Masís Luis Carlos , Marín Alfaro Anyerline
Published: November 2018

Se describe la percepción general de la población graduada del Bachillerato en Turismo Ecológico y Licenciatura en Gestión Ecoturística de la Universidad de Costa Rica, acerca de su proceso de formación en esta disciplina, así como sobre su desempeño profesional. La metodología abordó un enfoque cuantitativo y se trabajó con una muestra de 251 personas que obtuvieron su título entre 1995 y el año 2014, la cual es de tipo probabilística estratificada, considera la cantidad total de personas graduadas de cada unidad académica donde obtuvieron su diploma como un estrato; se utilizó una base de datos con información de contacto de todas las personas tituladas de la carrera y se aplicó un cuestionario en línea. Los resultados muestran la opinión acerca de su formación, con resultados satisfactorios, sobre el grado de uso de los conocimientos, habilidades y actitudes del perfil profesional, sobresale la aplicación de la teoría del desarrollo sostenible y su aplicación al turismo; en relación con las características académicas que requieren para un mejor desempeño laboral, son los idiomas como el inglés, el francés o el alemán; entre las áreas prioritarias del contexto donde la carrera debe incidir, destaca apoyar a las microempresas y comunidades vulnerables del turismo; y entre los mecanismos para fortalecer la inserción destaca la práctica profesional. Se exponen aspectos relacionados con la permanencia en el mercado laboral y, finalmente, se evidencian las necesidades y se proponen diversas acciones para mejorar el quehacer académico de esta disciplina. El estudio resulta relevante y constituye un referente para el proceso de mejoramiento de la carrera en todas las unidades académicas donde se imparte. La dificultad de la investigación radicó en contactar a los sujetos egresados, una población de difícil acceso.
Un modelo de afiliación informal: prácticas socioeducativas de estudiantes de la Sede Interuniversitaria de Alajuela
Authors: Cavallini Solano Hennia María
Published: November 2018

Este artículo es el producto generado de una de las dimensiones de análisis de la investigación denominada “Las capacidades de las personas de la comunidad que orientan la formulación del currículum de la carrera de ingeniería mecánica con énfasis en protección de incendios de la sede interuniversitaria de Alajuela”. Se busca develar el modelo de afiliación adoptado por la población de estudiantes, herramienta que servirá de base para la reformulación del currículo de la carrera de Ingeniería Mecánica con Énfasis en Protección de incendios. Este modelo se asocia a la capacidad de afiliación y se devela como práctica socioeducativa. El abordaje metodológico de este trabajo es de corte mixto, en el que se utilizaron diferentes estrategias de observación y entrevistas, que permitieron abordar, por medio de un sistema de votación y el programa Net Draw, la construcción gráfica de mapas de afiliación. Los principales hallazgos refieren a la caracterización de un modelo de afiliación informal de encadenamiento horizontal de corto plazo, dependiente de la zona espaciamiento.
Evaluación del currículo ofertado por la Universidad Estatal Amazónica para la carrera de Ingeniería en Turismo
Authors: Coromoto Marin Haideé , Soria Velasco Román Eduardo , Bravo Medina Carlos Alfredo , Reyes Vargas María Victoria , Gamboa Ríos María Germania , Manjarrez Fuentes Nelly Narcisa , Del Corral Villaroel Víctor Hugo
Published: November 2018

El currículo, para ser exitoso y de calidad, debe estar siendo evaluado permanentemente, con intención de mejorarlo y lograr así la plena formación del estudiantado. Esta se hace cada vez más importante, debido a que permite generar y obtener logros significativos en el proceso educacional en pro de un perfeccionamiento racional y científicamente válido para enfrentar los desafíos actuales. El objetivo de esta investigación fue realizar la evaluación curricular de la carrera de turismo de la UEA, a través de una metodología con enfoque epistemológico orientado al cambio. Se utilizó el método de la investigación acción participante, que consiste en un proceso sistemático que requiere la participación de todos los actores involucrados en el proceso de enseñanza aprendizaje (internos y externos), quienes tienen el conocimiento más profundo de sus problemas y su realidad. Los resultados de la investigación muestran los hallazgos, fallas, debilidades y aciertos que orientaron la toma de decisión para realizar los ajustes pertinentes y favorecer la calidad de la enseñanza, que es uno de los grandes desafíos de la educación superior del siglo XXI.
¿Nuevo paradigma en la política educativa chilena? Debates sobre educación y transformación social
Authors: Alarcón Leiva Jorge Alberto , Donoso Díaz Sebastián
Published: November 2018

El texto evalúa la pertinencia de entender las características de la reforma educativa en Chile, en continuidad con la idea de un cambio de paradigma de la política pública en educación. En este sentido, el artículo puntualiza la importancia de las movilizaciones estudiantiles de 2006 y 2011, encabezadas por estudiantes del nivel secundario y terciario, respectivamente, como instancias sociales críticas a la base de la generación de tal cambio. La noción de “paradigma”, acuñada por Kuhn, sirve así como concepto heurístico que permite expicar los fenómenos y su impacto. En relación con este objetivo, se analiza la situación de la política educativa chilena, con el propósito de dar cuenta de sus principales ejes de acción. Dichos ejes evidencian un estado de crisis, así como la necesidad de resolverla. No obstante, la eventualidad de alcanzar una solución a las dificultades del sector, colisionan con el punto de partida en virtud del cual se formulan las explicaciones acerca de por qué el sistema educativo chileno presenta estos rasgos. A este hecho es al que se denomina “empate neoliberal” y es el que, en opinión de los autores, exige un cambio de estándares de racionalidad.
Multilingual collaboration for news translation analysis: possibilities and limitations
Authors: Matsushita Kayo , Schäffner Christina
Published: November 2018

Advances in news gathering and dissemination technologies have made it possible that news stories are being shared simultaneously around the world. One internationally newsworthy event can generate dozens of news reports in multiple languages almost immediately by means of translation. Although news translation research has gained traction over the last 15 years, it has thus far tended to focus only on one language pair or on European language combinations because of practical limitations (e.g., language proficiency of researchers, access to content). This paper will illustrate the benefits of collaboration across languages and cultures for deepening our understanding of global news translation. To explore the possibilities as well as the limitations of this multilingual collaboration, a speech by the Japanese prime minister commemorating the 70th anniversary of Japan’s surrender ending World War II and reports about this speech in English and German media are analysed. For a detailed comparative analysis, two direct quotations from the speech were selected which were included in nearly all of the reports. We reflect on the variation identified in the news reports with reference to sources the journalists used, their own language proficiency and the potential role of an intermediary text or language.
Corpus-based study of news translation: challenges and possibilities
Authors: Cristina Caimotto Maria , Gaspari Federico
Published: November 2018

Recognizing that disciplinary confines often represent serious hurdles for translation scholars, this article offers a reflection on the boundaries of the subarea of news translation within the discipline of translation studies, focusing on its links with research that employs corpus-aided techniques, in particular critical discourse analysis and corpusassisted discourse studies. Reviewing a number of relevant studies and research projects that use different types of corpora, the discussion explores some of the main difficulties inherent in analysing translated news texts, which are often heavily mediated and edited in various ways; the ensuing key challenges associated with conducting journalistic translation research are examined. The article calls for mutual recognition and cross-fertilization between disciplines that investigate translated news from different, usually complementary, perspectives. In particular, the study of ideology and bias in translated news benefits from composite approaches and multi-faceted research projects that combine methods drawn from different areas: we argue that open and inclusive approaches are vital to uncover new and important insights into news translation.
Investigating translation flows: community radio news in South Africa
Authors: Van Rooyen Marlie
Published: November 2018

This article sets out to contribute to the debate and discussions on methodological approaches in news translation, focusing on a specific research question in a specific news context, namely community radio news in South Africa. Multilingualism and translation in community media has not been problematized within translation studies. In South Africa, research on multilingualism and the media has focused mainly on language planning and language policy, rather than practice. The hypothesis guiding this paper is that the multilingual nature of community radio in South Africa necessarily implies a multiple flow of translation into and from the country’s eleven official languages. The aim is, thus, to explore and describe the multilingual community radio landscape in the Free State province of South Africa, to map the translation flow. A mixed methods research design is followed to collect data and provide answers to the research questions posed.