bluuebunny/crossref_metadata_2025 huggingface dataset:
Argumentation Activity about the Sense of Vibration: Prediction-Observation-Explanation Strategy Based on the Resources Perspective
Authors: Ha Heesoo , Kim Heui-Baik
Published: November 2018

As an attempt to contribute to implementing scientific argumentation in classrooms, this study aimed to design an argumentation activity in which students were supported in engaging in the epistemic practices of scientific community. We reinterpreted prediction-observation-explanation strategy based on a resources perspective to acknowledge the role of students’ prior knowledge in their construction of arguments and to consider students as active participants with epistemic authority. This argumentation activity was intended to encourage students to construct scientific concepts with valid justifications based on their conceptual resources. Specifically, the activity consisted of three stages: (a) prediction with justification: predicting the result of the task and justifying the prediction; (b) observation: conducting the task to gather first-hand data: and (c) explanation with justification: reconstructing a valid argument with justification. We implemented this activity in classrooms to investigate its practical outcomes with students. The students were able to construct a rigorous argument on their own, evaluating and revising their arguments based on the resources they already possessed and the data they gathered in the observation stage. The results of this research shed light on how to develop scientific argumentation activities that support students as epistemic agents having the ability to construct scientifically rigorous arguments.
Addison’s disease in antiphospholipid syndrome: a rare complication
Authors: Oliveira Diana , Ventura Mara , Melo Miguel , Paiva Sandra , Carrilho Francisco
Published: November 2018

Addison’s disease (AD) is the most common endocrine manifestation of antiphospholipid syndrome (APS), but it remains a very rare complication of the syndrome. It is caused by adrenal venous thrombosis and consequent hemorrhagic infarction or by spontaneous (without thrombosis) adrenal hemorrhage, usually occurring after surgery or anticoagulant therapy. We present a clinical case of a 36-year-old female patient with a previous diagnosis of APS. She presented with multiple thrombotic events, including spontaneous abortions. During evaluation by the third episode of abortion, a CT imaging revealed an adrenal hematoma, but the patient was discharged without further investigation. A few weeks later, she presented in the emergency department with manifestations suggestive of adrenal insufficiency. Based on that assumption, she started therapy with glucocorticoids, with significant clinical improvement. After stabilization, additional investigation confirmed AD and excluded other etiologies; she also started mineralocorticoid replacement. This case illustrates a rare complication of APS that, if misdiagnosed, may be life threatening. A high index of suspicion is necessary for its diagnosis, and prompt treatment is crucial to reduce the morbidity and mortality potentially associated.

Learning points:

AD is a rare but life-threatening complication of APS.

It is important to look for AD in patients with APS and a suggestive clinical scenario.

APS must be excluded in patients with primary adrenal insufficiency and adrenal imaging revealing thrombosis/hemorrhage.

Glucocorticoid therapy should be promptly initiated when AD is suspected.

Mineralocorticoid replacement must be started when there is confirmed aldosterone deficiency.

Hypertension is a common feature of APS; in patients with APS and AD, replacement therapy with glucocorticoids and mineralocorticoids may jeopardize hypertension management.
Germline and somatic mosaicism in a family with multiple endocrine neoplasia type 1 (MEN1) syndrome
Authors: Beijers Hanneke J B H , Stikkelbroeck Nike M L , Mensenkamp Arjen R , Pfundt Rolph , van der Luijt Rob B , Timmers Henri J L M , Hermus Ad R M M , Kempers Marlies J E
Published: November 2018

Context

Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disease caused by mutations in the tumor suppressor gene MEN1 and can be diagnosed based on clinical, familial and/or genetic criteria. We present a family in which we found both germline and somatic mosaicism for MEN1.

Family description

In our proband, we diagnosed MEN1. The mutation was not detected in her parents (DNA extracted from leucocytes). When her brother was found to harbor the same MEN1 mutation as our proband and, around the same time, their father was diagnosed with a neuroendocrine carcinoma, this tumor was investigated for the MEN1 mutation as well. In the histologic biopsy of this tumor, the same MEN1 mutation was detected as previously found in his children. Re-analysis of his blood using multiplex ligation-dependent probe amplification (MLPA) showed a minimal, but consistently decreased signal for the MEN1-specific MLPA probes. The deletion was confirmed in his son by high-resolution array analysis. Based on the array data, we concluded that the deletion was limited to the MEN1 gene and that the father had both germline and somatic mosaicism for MEN1.

Conclusions

To our knowledge, this is the first reported family with combined germline and somatic mosaicism for MEN1. This study illustrates that germline mosaicism is important to consider in apparently sporadic de novo MEN1 mutations, because of its particular importance for genetic counseling, specifically when evaluating the risk for family members and when considering the possibility of somatic mosaicism in the parent with germline mosaicism.
HDAC inhibitors impair Fshb subunit expression in murine gonadotrope cells
Authors: Schang Gauthier , Toufaily Chirine , Bernard Daniel J
Published: November 2018

Fertility is dependent on follicle-stimulating hormone (FSH), a product of gonadotrope cells of the anterior pituitary gland. Hypothalamic gonadotropin-releasing hormone (GnRH) and intra-pituitary activins are regarded as the primary drivers of FSH synthesis and secretion. Both stimulate expression of the FSH beta subunit gene (Fshb), although the underlying mechanisms of GnRH action are poorly described relative to those of the activins. There is currently no consensus on how GnRH regulatesFshbtranscription, as results vary across species and betweenin vivoandin vitroapproaches. One of the more fully developed models suggests that the murineFshbpromoter is tonically repressed by histone deacetylases (HDACs) and that GnRH relieves this repression, at least in immortalized murine gonadotrope-like cells (LβT2 and αT3-1). In contrast, we observed that the class I/II HDAC inhibitor trichostatin A (TSA) robustly inhibited basal, activin A-, and GnRH-inducedFshbmRNA expression in LβT2 cells and in primary murine pituitary cultures. Similar results were obtained with the class I specific HDAC inhibitor, entinostat, whereas two class II-specific inhibitors, MC1568 and TMP269, had no effects onFshbexpression. Collectively, these data suggest that class I HDACs are positive, not negative, regulators ofFshbexpressionin vitroand that, contrary to earlier reports, GnRH may not stimulateFshbby inhibiting HDAC-mediated repression of the gene.
Value Propositions in Service Systems Enabled by Digital Technology: A Field Based Design Science Approach
Authors: Genennig Stefan Michael , Roth Angela , Jonas Julia M. , Moslein Kathrin M.
Published: November 2018

In the context of the digitization of business environments, organizations and processes are currently undergoing major changes. Digital transformation offers a high potential to develop new value propositions by using digital technology, but at the same time demands for the implementation of disruptive innovation in complex service systems. Thereby, it is crucial to find out how to make use of technology-enabled potentials and how to find a structured way to develop and design new value propositions, embedded in service systems. To support the development and design of value propositions, this paper designs the VdiP-developer as a framework for the systematic development of digitization-enabled value propositions in service systems. It considers the advancement of existing likewise the development of new value propositions. In particular, the VdiP-developer highlights the roles of digital technology in service systems and establishes a framework to consider both, digital technology and service systems, in the development of value propositions. Using a field-based design-science approach to research, this paper shows how the framework for value proposition building is iteratively developed, applied and evaluated as a joint initiative by researchers and practitioners. The designed artefact, the VdiP-developer, enables organizations to systematically improve and develop value propositions by bringing management perspectives and service design elements together in one compact framework.
TEACHERS' PERSPECTIVE ON THE IMPLEMENTATION OF COMMUNICATIVE APPROACH IN INDONESIAN CLASSROOMS
Authors: Rahmawati Yenny
Published: November 2018

ABSTRACTCommunicative Approach (CA) is probably the most popular approach in the recent English language teaching (ELT) in Indonesia. The curriculum underpinning ELT in the country has changed several times, although in the last 35 years its basis has been revolving around the communicative approach. Despite the fact that the communicative curriculum has been implemented for a long time, some research studies (Dardjowidjojo, 2000; Musthafa, 2001) indicated that it has not brought significant improvements in the terms of learners’ outcome. The reason for this might be a number of the teachers appear to have developed some misconceptions of CLT. This study is, therefore, aimed at exploring EFL Indonesian teachers’ perspectives toward communicative approach in their classrooms. Six participants were involved in this study in which two participants were chosen from each level of education (primary, secondary and university levels). The study employed a qualitative design by using questionnaire and in-depth interviews as methods of data collection. The results indicated that the university teachers in this study tend to have a broader view of CLT, while a number of the school teachers appear to have developed some misconceptions of it, i.e. the “not” teaching grammar and the teaching “only” speaking. ABSTRAKPendekatan Komunikatif (CA) mungkin merupakan pendekatan yang paling populer dalam pengajaran bahasa Inggris (ELT) di Indonesia. Kurikulum yang mendasari ELT di Negara ini telah berubah beberapa kali, meskipun dalam 35 tahun terakhir pendekatan yang digunakan adalah pendekatan komunikatif. Terlepas dari kenyataan bahwa kurikulum komunikatif telah dilaksanakan dalam waktu yang lama, beberapa penelitian (Dardjowidjojo, 2000; Musthafa, 2001) menunjukkan bahwa pendekatan tersebut tidak membawa perbaikan yang signifikan bagi peserta didik. Alasan utama hal tersebut mungkin datang dari kesalahpahaman sejumlah guru terkait dengan CLT. Oleh karena itu, penelitian ini bertujuan untuk mengeksplorasi perspektif guru bahasa Inggrois terhadap pendekatan komunikatif di kelas mereka. Enam peserta terlibat dalam penelitian ini di mana dua peserta dipilih dari setiap jenjang pendidikan (tingkat dasar, menengah dan universitas). Penelitian ini menggunakan desain kualitatif dengan menggunakan kuesioner dan wawancara mendalam sebagai metode pengumpulan data. Hasil penelitian ini menunjukkan bahwa guru universitas dalam penelitian ini cenderung memiliki pandangan yang lebih luas tentang CLT, sementara sejumlah guru sekolah tampaknya telah mengembangkan beberapa kesalahpahaman diantaranya: "tidak" mengajar tata bahasa dan pengajaran "hanya" berbicara.  How to Cite: Rahmawati, Y.(2018). Teachers' Perspective on The Implementation of Communicative Approach in Indonesian Classrooms  . IJEE (Indonesian Journal of English Education), 5(1), 92-100. doi:10.15408/ijee.v5i1.9881
Improving lives in our global society by being at the forefront of the smart infrastructure revolution
Authors: Wyllie Andrew
Published: November 2018

This is the inaugural address of Andrew Wyllie CBE, who became the 154th president of the Institution of Civil Engineers on 6 November 2018.
Stratified slopes, numerical and empirical stability analysis
Authors: Sauffisseau Rémi , Ahangar-Asr Alireza
Published: November 2018

Urbanisation means that many natural slopes in and around cities are often subjected to cuts resulting in dramatic changes in the geometry of slope faces mostly by increasing slope angle, which could lead to failures with catastrophic consequences. As most natural slopes are of non-homogeneous layered nature, understanding the stability behaviour of such slopes will be of utmost importance. The current practice in analysing slopes of complicated nature, geometrically and materially, is mostly to apply simplifications sacrificing accuracy leading to use of large factors of safety (FoS), which could undermine analytical and economic feasibility of projects. In this research study, limit-equilibrium and finite-element methods are used by the Oasys slope and Plaxis 2D software programs, respectively, empirically and numerically to model and analyse geometrically non-homogeneous stratified slopes with the aim of understanding the effects of non-homogeneity of geometry and materials on stability under various inclination angles of slope face. The analysis included determination of FoS as well as a sensitivity analysis looking into the combined effects of contributing parameters.
Grönroos Hizmet Kalitesi Modeli: Otelcilik Alanyazını Üzerinden Bir Değerlendirme
Authors: AKOĞLAN KOZAK Meryem , AYDIN Birgül
Published: November 2018

Bu çalışmanın amacı, Grönroos hizmet kalitesi modelini otel işletmeciliği alanyazını kapsamında değerlendirmektir. Bu bağlamda, Grönroos hizmet kalitesi modelinin boyutları olan teknik, fonksiyonel ve imaj ile ilgili çalışmalar incelenmiştir. Araştırmada, Gömülü Teori’den yararlanılmıştır. Alanyazın üzerinden yapılan değerlendirmeler ve Gömülü Teori analizi kapsamında elde edilen sonuçlar iki kategori altında toplanmıştır. Bu kategoriler, standartlaştırmanın rolü ve etkileşimin önemidir. Bu iki kategori kapsamındaki değerlendirmeler neticesinde; hizmet kalitesinde standartlaştırmanın işletmelerin performansını artırdığı ve işletmelere olumlu imaj sağladığı; müşterilerin kalite algılamalarında, personelin davranışları ve fiziksel çevreyle etkileşimin önemli olduğu belirlenmiştir. Grönroos hizmet kalitesi modelinin, hizmet kalitesiyle ilgili çalışmalara bütüncül bir bakış açısı sağlaması nedeniyle araştırmacılar tarafından kullanılabileceği önerilmiştir.
Turizmin Yöre Halkının Yaşam Kalitesine Etkileri: Çeşme İlçesi Örneği
Authors: Avcı Nilgün
Published: November 2018

Bu çalışmada önemli bir turizm destinasyonu olan İzmir’in Çeşme ilçesinde yaşayan yöre halkının yaşam kalitesinde turizmin etkileri araştırılmıştır. Araştırmada nicel araştırma yöntemlerinden alan araştırması benimsenmiş, verilerin toplanmasında anket tekniği kullanılmıştır. Veriler kolayda örnekleme yöntemiyle Çeşme’de ikamet eden yöre halkından yüz yüze toplanmıştır. Turizmin etkileri; ekonomik, kültürel, sosyal ve çevresel etkiler olarak ele alınmıştır. Yaşam kalitesi boyutları da toplumsal yaşam, sağlık-güvenlik ve ekonomik durum olarak incelenmiştir. Çalışmada, faktör analizi, t-testi, ANOVA, korelasyon analizi uygulanmış, turizmin yaşam kalitesine etkisini belirlemek için regresyon analizi kullanılmıştır. Çalışmanın bulgularına göre, turizmin ekonomik, kültürel ve sosyal etkilerinin Çeşme’de yaşayan yöre halkının yaşam kalitesini etkilediği, ancak turizmin çevresel etkilerinin yaşam kalitesini etkilemediği belirlenmiştir.
Kastamonu’da Yeniden İşlevlendirilen Tarihi Yapıların Sürdürülebilirliğe Etki Eden Çekicilik Faktörleri
Authors: Saraç Ömer , Tanrısever Canan
Published: November 2018

Süreç içinde hızla gelişen bilim ve teknoloji; bireylerin çalışma şartlarında, aile yapılarında, dünya görüşlerinde, inançlarında ve gereksinimlerinde değişikliklerin yaşanmasına neden olmuştur. Bu değişiklikler sonucunda birçok tarihi yapı işlevini kaybetmiş, terk edilmiş ve atıl kalmıştır. Atıl kalan bu yapılar, turizmde sürdürülebilirliğin öneminin anlaşılmasıyla değer kazanmış, yaşatılma ilkesi çerçevesinde yeniden işlevlendirilmiştir. Bu durumun bir sonucu olarak kıt kaynaklar korunmuş, kültürel sürdürülebilirlik gerçekleştirilmiş ve yapıların çevresine sosyal, kültürel ve ekonomik katkı sağlanmıştır. Bu olguya koşut olarak, bu çalışmada Kastamonu’da yer alan tarihi konakların tercih edilerek yaşatılmasını sağlayan çekicilik faktörlerinin neler olduğu anket tekniğiyle araştırılmıştır. Verilerin analizinde istatistik paket programı kullanılarak “yüzde” ve “sıklık” haricinde, parametrik olmayan “Mann Whitney U” ve “Kruskal Wallis” testlerine başvurulmuştur. Araştırmanın sonuçlarına göre konak otellerin tercih edilmesini sağlayan faktörler: meslek, ekonomik durum, kültür ve yaşam tarzıdır. Ayrıca bu faktörlerin turistlerin bireysel özelliklerinden, cinsiyet, eğitim durumu ve toplam aylık gelire göre anlamlı farklılık gösterdiği tespit edilmiştir.
Reliability assessment of the South African wind load design formulation
Authors: Botha J , Retief J , Viljoen C
Published: November 2018

The representation of the strong wind climate and the reliability calibration of wind loading are the main components of the provisions for local conditions in the South African wind load standard. The reliability implications of new probability models for wind load and an updated map of the characteristic wind speed are assessed in this paper. Wind load probability distributions are based on a combination of new models for free-field wind pressure, pressure coefficients and terrain factors with existing information. The results from both assessments show that the wind load partial factor of 1.3 does not result in adequate reliability performance for typical design situations. A partial factor of 1.6 is recommended. Where an increased partial factor for wind loading will result in a corresponding increase in the design wind load, the introduction of an updated map of the characteristic wind speed for South Africa is shown to result in an overall reduction of wind load. Regional analysis, however, indicates that there are regions in the Western and Eastern Cape that will have increased design wind loads. Combined with an updated partial factor of 1.6, the aggregate increase in design wind loads across South Africa is shown to be 11%.
A numerical investigation on hydro-mechanical behaviour of a high centreline tailings dam
Authors: Naeini M , Akhtarpour A
Published: November 2018

The high rate of failure in tailings dams reflects the inadequacy of conventional stability and seepage analyses for evaluating their performance, especially during construction. In this article, the hydro-mechanical behaviour of a high centreline tailings dam during staged construction is evaluated by coupled stress-pore pressure analyses. The effects of factors such as foundation permeability, raising rate, anisotropic permeability of slimes and changes in the slope of dykes on the structural response are investigated. In these analyses, a combination of realistic conditions, including saturated-unsaturated seepage of materials, consolidation and loading due to staged construction are simulated using SIGMA/W software. The results of this study indicate that foundation permeability and anisotropic permeability of slimes have a significant influence on development of pore pressure in impoundment, while changing the downstream slope of dykes causes substantial displacements.
Potential of marula (Sclerocarya birrea subsp. caffra) waste for the production of vinegar through surface and submerged fermentation
Authors: Molelekoa Tumisi J. , Regnier Thierry , Da Silva Laura S. , Augustyn Wilma A.
Published: November 2018

Although there is an abundance of indigenous fruits in South Africa, knowledge of their potential uses is mainly restricted to within communities. In this study, marula fruit-processing waste by-products (fruit pulp residue and skin) were used as substrates in surface culture and submerged fermentation methods to produce vinegar (acetic acid) using spontaneous and starter culture techniques. The study revealed the possibility of producing vinegar through both methods of fermentation, with yields of acetic acid ranging between 41 000 mg/L and 57 000 mg/L (surface culture method) and between 41 000 and 54 000 mg/L (submerged culture method). Furthermore, the physicochemical property analyses revealed marula vinegar to be a potential source of bioactive compounds (total phenolics 0.289–0.356 mg/L GAE and total flavonoids 0.146–0.153 mg/L CAE) which displayed a potent antiradical activity against DPPH•: 78.85% for surface culture and 73.03% submerged culture, respectively. The sensory panel recommended application of the vinegar in products such as salad dressing and mayonnaise. Finally, we have demonstrated that the surface culture method using the inoculation technique is more suitable for the production of high-quality vinegar, with possible consideration for commercialisation.Significance:

Marula fruit has high economic importance for South Africa, particularly for the Limpopo Province.
Marula waste can be a source of bioactive compounds, yet comparatively little is reported on the potential use of the waste to produce vinegar.
Self-development of communities through viable and easy to produce commodities from marula fruit needs to be implemented and prioritised in the Limpopo Province.
Big science and human development – what is the connection?
Authors: Gastrow Michael , Oppelt Thelma
Published: November 2018

The rationale for public expenditure and political support for large-scale science infrastructure is commonly underpinned by a universalist logic of big science’s benefits. Literature assessing the impact of big science focuses on its contributions towards new fundamental insights about the universe; the development of skills, capabilities, networks, and innovation; and the development of globally transformative technology platforms that in turn make significant impacts on global human development. However, research into the local development impact of big science infrastructure is scarce. In this paper we reflect on the development impact of a big science project at the local level, drawing on the case study of the Square Kilometre Array telescope in South Africa’s Karoo region. We find that the universalist logic that appears to apply at the global and national levels does not necessarily apply at the local level, where big science has resulted in human development benefits, but also substantial economic and social costs. On this basis we recommend that big science infrastructures, particularly in marginalised areas of developing countries, require a localised development proposition that takes into account local social complexities on the basis of extensive local engagement.Significance:

A synthetic review is presented of the different causal pathways through which big science may impact on human development.
Analytical distinctions are developed between the human development impacts of big science at the global, national, and local scales.
Considerations are put forward for a developmental agenda for big science facilities, particularly in developing countries.
Саунд-стадиз в обход аудиальной культуры
Authors: Кейн Брайан
Published: November 2018

Термины «исследования звука» (sound studies) и «аудиальная культура» (auditory culture)1 часто используются как синонимы, означающие широкое, гетерогенное, мультидисциплинарное исследовательское поле. Тем не менее между ними остается потенциальное расхождение. Некоторые представители саунд-стадиз, обращаясь к онтологии звука и материально-аффективным процессам, стоящим «за репрезентацией и сигнификацией», не признают исследования в области аудиальной культуры. В настоящей статье я рассмотрю «онтологический поворот» в саунд-стадиз на примере работ трех авторов (Стива Гудмана, Кристофа Кокса и Грега Хайнджа) и предложу несколько аргументов против него. Вначале я опишу концептуальную рамку делезианской метафизики, которую они разделяют. Далее я рассмотрю онтологию вибраций Гудмана. Гудман утверждает, что преодолел дуализм, а я доказываю, что его теория жестко дуалистична и менее убедительно объясняет соотношение осознания (cognition) и аффекта, чем критикуемые им подходы к объяснению познания через культуру и репрезентацию. Затем я рассмотрю эстетические теории Кокса и Хайнджа, сторонников онто-эстетики — теории о том, что произведения искусства способны раскрывать свою онтологию. Я полагаю, что онтоэстетика зиждется на категориальной ошибке, возникшей из-за путаницы между воплощением и экземплификацией. Вследствие этой путаницы Кокс и Хайндж незаметно встраивают в свой предположительно культурно независимый анализ произведений искусства аналогии, фундированные в культуре. В заключение я порассуждаю об аудиальной культуре и внесу предположение о том, что «онтологический поворот» в саунд-стадиз на самом деле является формой «онтографии» — описания онтологических допущений (commitments) и представлений (beliefs) конкретных субъектов или сообществ — которая на свой страх и риск пренебрегает конститутивной ролью аудиальной культуры2.

____________________________

1 Перевод выполнен М. Шкурко, В. Бродской по: Kane B. Sound Studies without Auditory Culture: A Critique of the Ontological Turn // Sound Studies. 2015. Vol. 1. No. 1. P. 2–21.

2 Далее в тексте название междисциплинарной области, посвященной исследованиям звука, будет приведено как «саунд-стадиз» (по аналогии с русскоязычными кальками «синема-стадиз», «гейм-стадиз» и др.). Для обозначения области исследований аудиальной культуры также будет использоваться калька с формулировки автора — «исследования аудиальной культуры» (Примеч. пер.).
Звуковые практики и материальность городского пространства
Authors: Логутов Андрей Владимирович
Published: November 2018

В статье рассматривается звуковое пространство города в контексте различения приватной и публичной сфер. Апеллируя к идеям М. Маклюэна, Р.М. Шейфера, Дж. Мовитта, автор предлагает видеть в аудиальных городских практиках медийные интерфейсы, работающие на стыке публичного и приватного. Эти интерфейсы имеют конкретно-материальную природу, что осложняет их картографирование и теоретическое освоение. Выдвигается гипотеза о том, что обращение к аудиальной модальности позволяет плодотворно описывать некоторые типы взаимодействия между публичным и приватным. В качестве примеров рассматриваются некоторые практики городского слушания.
The connection between chronic diseases and self-image and self-esteem
Authors: Filej Bojana , Žvanut Boštjan , Kaučič Boris Miha
Published: November 2018

Introduction: With aging, the incidence of chronic diseases among elderly increases, as about 88% of them have at least one chronic condition, with 50% having at least two. The presence of these diseases influences their self-image and self-esteem. This study aimed to identify the effects of chronic diseases on self-esteem and self-image in the group of elderly people.

Methods: A quantitative research design using a structured questionnaire was employed, where Rosenberg questionnaire with an adapted measurement scale was used for evaluating self-esteem, while Marsh’s adjusted Multidimensional self-concept scale was used for assessing self-image.

Results: The survey involved 51 respondents: 25.5% were male, and 74.5% were female, the average age of the respondents was 77.0 years. 60.8 % of them reported high blood pressure, 31.4% rheumatism, 25.5% osteoporosis and 23.5% diabetes. “Rheumatism” was statistically significantly associated with two elements of self-esteem: the “athletic self-esteem” and “inclusion”, whereas the claim for self-assessment “I can do things as good the majority of other people” was associated to the incidence of  “diabetes”.

Conclusions: The results of our study indicate that rheumatism, as a most common chronic disease among this population, has a significant impact on some elements of self-image and self-esteem. Further research should focus on the concepts of self-esteem and self-image of this population.
CURRENT UNDERSTANDING OF ANTITUMOR IMMUNITY
Authors: Shubina I. Zh. , Sergeev A. V. , Mamedova L. T. , Sokolov N. Yu. , Kiselevsky M. V.
Published: November 2018

The review presents analysis of the papers that discuss mechanisms of antitumor immunity. The role of innate and adaptive immune reactions as well as local and systemic is considered in terms of immune defense in clinical and experimental studies. The article discusses characteristics and role tumor-associated antigens for clinical practice. Various types of immune effector cells, including T-cells, NK-cell, DC, tumor associated macrophages, etc., and cytokines, are discussed regarding their contribution into antitumor immune response. The authors also refer to the hypothesis of “immunoediting” and its part in antitumor immunity.
EVALUATING THE EFFECTIVENESS OF THE COMBINED TREATMENT OF PATIENTS WITH COLORECTAL CANCER, BREAST CANCERAND CANCER OF THE FLOOR OF THE MOUTH USING A STERILE HYDROGEL MATERIAL "KOLEGEL 5-FTUR"
Authors: Korytova L. I. , Sokurenko V. P. , Maslyukova E. A. , Meshechkin A. V. , Oltarzhevskaya N. D. , Korovina M. A. , Gusev I. V. , Kuznetsov A. D. , Krasnikova V. G. , Obuhov E. M.
Published: November 2018

The article is devoted to the effectiveness evaluation of the use of sterile material «Kolegel 5-ftur» on the basis of sodium alginate with 5-fluorouracil, as of shape of disk, in the course of chemoradiotherapy in patients with rectal cancer, breast cancer and cancer of the floor of the mouth. The study group included 38 patients: 19 patients diagnosed with CRR, 10 patients -BC, 9 patients - a cancer of the mouth floor. The study used a hydrogel material «Kolegel 5-ftur» during chemoradia- tion therapy for histologically confirmed diagnosis of a malignant tumor. The effectiveness of the combined treatment is proved by the following criteria: local control of the tumor, the analysis of toxicity and immediate effect. Thus, the use of hydrogel materials «Kolegel-5-ftur» in group of patients with primary malignant tumor localization in the floor of the mouth, with the aggressive chemotherapy provided enhancing the effectiveness of therapy.
Stimulation of metastatic activity of breast cancer cells by plasma exosomes
Authors: Samsonov R. B. , Kovalenko I. M. , Vasilyev D. A. , Tsyrlina E. V. , Dashan G. A. , Shochat-Carvalho Ch. . , Karasik D. . , Berstein L. M. , Lutynskij V. V. , Malek A. V.
Published: November 2018

Background. Malignant phenotype of cancer cells and metastatic potency of the tumor are determined by genetic factors. In addition, normal biological environment, including the nano-vesicles or exosomes, plays an important role in regulation of the structural and functional characteristics of malignant cells. Objective: presented study was aimed to evaluate mechanisms and to estimate effect of interaction of plasma exosomes and breast cancer cells in experimental conditions. Materials and methods. We used breast cancer cell culture MDA-MB-231 and exosomes isolated from plasma and cultural medium. Exosomes were analyzed by dynamic light scattering method and western blotting. Functional effects of exosomes were evaluated in in vitro and in vivo models. Results. In the present study we demonstrated that plasma exosomes stimulate the adhesion and the motility of breast cancer cells and induce the process of metastatic dissemination. Contact interaction of exosomes with cell surface is sufficient for stimulatory effect that is mediated by exosomal fibronectin and FAK-dependent signaling cascade. Conclusions. Further investigation of plasma exosomes structure and functions is required to better understand their input in regulation of malignant cell phenotype. This research has a potential to provide novel approaches for cancer therapy.
THE CHARACTERISTIC OF BONE MARROW STEM CELLS OF PATIENTS WITH THE COMPLICATED DIABETES
Authors: Nikolaeva L. P. , Cherdantsev D. V. , Titov K. S.
Published: November 2018

Introduction. An increase in patients with diabetes and a large number of amputations of limbs make the search for new treatments for these patients. Materials and methods. The study included 17 patients with complicated forms of diabetes. Patients were studied in the bone marrow immediately after surgery - the amputation of the limb. The number of hematopoietic stem cells and mesenchymal stem cells using specific markers were determined in the laboratory. The immunohistochemical characteristics of bone marrow were carried out for all samples. Results and conclusion. The obtained results indicate the biological value of bone marrow removed with amputation of the lower limb of the patient with complicated diabetes mellitus. The ease of obtaining bone marrow makes the procedure approachable in surgical practice. The presence of hematopoietic and mesenchymal stem cells provides the opportunity to use them in autologous cell therapy for patient.
TOURISM PRODUCT DEVELOPMENT POSSIBILITIES IN RIEBINI MUNICIPALITY
Authors: Dembovska Iveta , Silicka Inese , Litavniece Lienīte
Published: November 2018

Tourism is one of the driving forces of the global economy, and its role in the national economies increases every year. Tourism is one of the leading export industries in the world, which, despite challenges and turbulences, develops steadily. However, to attract the attention and flow of tourists to the rural areas, it is important to create attractive and sustainable tourism products that could turn into tourist destinations. The aim of the research is to explore and identify possibilities for tourism product development in Riebini municipality. The following tasks were set to achieve the aim: to explore the theoretical aspects of tourism product and cultural tourism product development; to identify possibilities for tourism product development in Riebini municipality. The methods applied in the research: logical and constructive, synthesis and analysis, empirical survey.  The research study was carried out within the framework of RTA research grant No. 13.15/5 “Maintenance and renewal of the cultural and natural heritage in Riebini municipality”.  The authors have developed proposals for development of the tourism sites in Riebini municipality that could transform them into tourist destinations.
THE PRINCIPLES OF DEMOCRACY IN ADOPTION OF NORMATIVE ACTS
Authors: Krampuža Ilga
Published: November 2018

The report describes the current problem - the disproportionately large increase in the number of normative acts. Such a situation frightens the society, creates distrust to the state administration and causes errors in adoption of normative acts, which shall be corrected. Therefore, the excessive increase in the number of normative acts is negative. Before adopting the normative acts, it is proposed to consider all possibilities for solving a specific problem. The importance of the principle of democracy in reducing the increase of normative acts has been raised. The aim of the report is to provide a general insight into the tasks of normative acts; to update general guidelines on the basis of the principle of democracy, which confirms that the adoption of normative acts should be evaluated in conjunction with the consideration of other criteria for solving a specific problem.The tasks of the research are the following: to update the connection of the adoption of normative acts with the essence of the principle of democracy; to analyse the growth rates of normative acts; to study the reasons for the increase in the number of normative acts; to put forward the principle of democracy as a limiter for the growth of normative acts. In the research, the grammatical method is used to present description of the normative acts adoption process, as well as to provide review of the reasons for the increase in the number of normative acts. The systemic method is used to assess the possibilities of interpreting the principle of democracy, based on the case law of the Constitutional Court of the Republic of Latvia and the legal doctrine. The analytical method is used to describe the disproportionately rapid increase of normative acts. The analytical method is applied to evaluate the possibilities of using the principle of democracy to reduce the number of normative acts. Using the teleological method, an increase in the number of normative acts is considered in the context of the essence of the principle of democracy.The results of the research are reflected in the main conclusions: the increase in the number of normative acts in the recent years has to be regarded as unreasonable and contrary to the public interest; the principle of democracy requires that solution to the problem, firstly, shall be sought for in the legal system; based on the principle of democracy, the usefulness, purpose and implementation of the public interest in adoption of new normative acts should be considered.
THE ROLE OF THE STOCK MARKET IN THE MOBILIZATION OF LONG-TERM FINANCIAL RESOURCES
Authors: Gasimova Lamiya
Published: November 2018

The main purpose of the research is to define mobilization of long-term financial resources in the stock market, to analyse the current situation and give some suggestions for improvement of investment. The author tries to research the impact of investment on the stock market because everyone knows long-term financial resources are very significant for the market and affect economic growth. The paper examines the current state of investment activity in the stock market in our republic and around the world, as well as the impact on the economy of this activity is investigated. The author investigates the impact of investment activity in the stock market on the economy and ways of correct use of investment activity. Indeed, investment is a long-term investment in various sectors of the economy for making profit. Investment – consists of financial means put into objects of entrepreneurship and other types of activity, as well as material and intellectual resources for the purpose of earning (profit) or social benefits. Despite its popularity and presence in the news, the stock market is just one of many potential places to invest your money. Investing in stocks is often risky, which draws attention to the huge gains and losses of some investors. If you manage the risks, you can take advantage of the stock market to secure your financial position and earn money.
ASSESSMENT OF INCOME TAXATION OF PERFORMERS OF ECONOMIC ACTIVITIES
Authors: Puzule Anita , Svika Inguna
Published: November 2018

In the changing economic situation of nowadays, flexible forms of employment become more popular, and a performer of economic activities is one of them. They have to face the inconstant tax policy of Latvia, be able to choose a payment regime from earned income, which is most suitable for them. The authors believe it is worthwhile to find out the opinions of performers of economics activities and to assess tax liabilities, which is an important requirement for the planning and development of their activities.   The goal of the research is to assess the taxable income regimes for performers of economic activities in Latvia and to find out their opinion on their satisfaction with the tax policy. The approaches of the research are: the monographic and descriptive methods, document analysis, logically construction, statistical analysis, and a sociological research method – a pilot survey. The research resulted in the assessment of taxable income regimes and their application in various situations. By conducting the pilot survey, it has been discovered that performers of economics activities find it difficult to understand standard regulations and accounting management; they lack comprehension of the importance of SSIMC and its advantage for the future. The calculations made by the authors show the amounts of the tax burden formed with each tax payment regime.
ROLE OF LEADERSHIP AND POSSIBILITES FOR ITS DISPLAY IN THE STATE BORDER GUARD
Authors: Kublickis Raimonds , Arbidāne Iluta , Znotiņa Daina
Published: November 2018

The authors explore the display of leadership in the State Border Guard in order to find out whether there is a place for leadership and the human factor in the relationship between management and subordinates in the strictly regulated organization. The aim of the research: to study the role of leadership and its display in the State Border Guard. Tasks of the research: 1) to describe the nature of leadership and its role in the organization's activities; 2) to conduct a survey on the most significant aspects of leadership manifestation in regards inspectors and officers from different border guard units of the State Border Guard; 3) to make conclusions and develop proposals regarding the necessity of leadership and possibilities for its display. The research methods: 1) literature analysis, observation; 2) surveying, data processing, analysis, and interpretation. At the end of the research, the authors conclude that the respect and appreciation provided by the superior to the subordinates is as important as a good salary and work conditions at the State Border Guard. Hence, in the opinion of the subordinates, a superior who can display the respect and appreciation to the subordinates will be able to become the leader. Even in a strictly regulated organization such as the State Border Guard, the superior can offer his/her subordinates the assistance – not by completing a task on behalf of the subordinate, but by providing the advice and guidance. This behaviour is an attribute of a democratic management style creating a favourable ground for leadership development.
«Дневныя записки Петра Ознобишина с 1796 года сентября»: тезаурусный подход
Authors: Буранок Олег Михайлович , Буранок Сергей Олегович
Published: November 2018

Статья посвящена анализу рукописи «Дневныя записки Петра Ознобишина с 1796 года сентября». Рассмотрены особенности взглядов провинциального дворянина на государственных деятелей и чиновников, его общественные настроения, отраженные в дневнике. Изучение дневников конца XVIII в. актуально как для исторической науки, так и для литературоведения и культурологии, поскольку позволяет более точно понять не только конкретно-исторические явления и события, но и социокультурный контекст эпохи. И в этом плане невозможно обращаться только к источникам личного происхождения видных политических и государственных деятелей, необходим анализ дневников рядовых представителей российского общества, особенно если речь идет о еще не изданных источниках.
В статье дано источниковедческое описание дневника. Показаны его возможности для анализа повседневной жизни русского дворянства, а также жизни провинциальных городов конца XVIII в. Тезаурусный подход в этом отношении позволяет лучше понять особенности повседневности того времени, сделать выводы о национальном вопросе в Российской империи, о взаимодействии различных народов на юге страны и о восприятии их деятельности русским дворянством. 
Concepciones de los Docentes sobre la Evaluación Socialmente Justa
Authors: Murillo F. Javier , Hidalgo Nina
Published: November 2018

RESUMENEl presente estudio busca conocer las concepciones de docentes sobre una evaluación socialmente justa. Para alcanzar dicho objetivo, se ha llevado a cabo una investigación fenomenográfica en la que han participado 30 docentes de educación Primaria y Secundaria, de centros públicos y privados y situados en contextos socioeconómicos favorables y desafiantes. Los resultados obtenidos muestran que los docentes conciben una evaluación socialmente justa conformada por seis elementos: una evaluación para el aprendizaje (más que del aprendizaje), equitativa y diferenciada para cada estudiante, participativa, que contribuya a la toma de conciencia social, que valore la autoestima y la empatía, y que favorezca y considere la capacidad reflexiva y critica de los estudiantes. Los hallazgos del estudio ponen de manifiesto la importancia de profundizar en concepciones sobre una evaluación socialmente justa del alumnado ya que la práctica evaluativa tiene claras repercusiones en la vida social y académica de los estudiantes.Palabras Clave: Evaluación de estudiantes, Evaluación socialmente justa, Concepciones de evaluación, Investigación fenomenográfica.ABSTRACTThe present study seeks to know assessment teachers’ conceptions about what is a socially just assessment. To achieve this objective, a phenomenographical research has been carried out in which 30 teachers of Primary and Secondary education have participated, from public and private schools located in favourable and challenging contexts. The results obtained show how teachers conceive a socially just assessment consisting of six elements: assessment for learning (rather than learning), equitable and differentiated for each student, that contributes to social awareness, which value self-esteem and empathy, and that favor and consider the reflective and critical capacity of students. The findings of our study show the importance of deepening into conceptions about a socially just assessment of students since assessment practice has clear repercussions in social and academic students’ life.Keywords: Students assessment, Socially just assessment, Assessment conceptions, Phenomenographic research.
Satisfaction degree of English teachers of Preschool and Primary Education in the Principality of Asturias
Authors: Fernández-Costales Alberto , González-Riaño Xosé Antón
Published: November 2018

ABSTRACTThis paper analyses the satisfaction level of teachers of English in Preschool and Primary Education in the Principality of Asturias (Spain). The sample was composed of 238 teachers from 68 schools and the research tool was a 45-item questionnaire. Data were processed with SPSS, and variance analyses were performed to assess the impact of the variables considered. The main results confirm that general satisfaction is rather high, although it is possible to identify improvement proposals in relation to the social recognition of teaching, the professional status and the acknowledgement of the teaching activity by education authorities. In addition, the results show that age, educational stage, and administrative status influence teachers’ satisfaction.Keywords: Teacher satisfaction, English teachers, English as a Foreign Language (EFL), Preschool Education, Primary Education.RESUMENEste trabajo analiza la satisfacción docente de los maestros de Inglés en Educación Infantil y Primaria en el Principado de Asturias. La muestra del estudio incluye a 238 maestros de 68 centros y el instrumento de investigación fue un cuestionario de 45 ítems. Los datos obtenidos fueron procesados con SPSS y se realizaron análisis de la varianza para medir el impacto de las variables consideradas. Los principales resultados confirman que la satisfacción general de los docentes es elevada, aunque es posible identificar propuestas de mejora en relación con el reconocimiento social de la profesión, el estatus profesional, y el reconocimiento de la labor docente por parte de las autoridades educativas. Además, los resultados confirman que la edad, la etapa educativa, y el estatus administrativo tienen influencia en la satisfacción docente.Palabras Clave: Satisfacción docente, maestros de inglés, Inglés como lengua extranjera, Educación Infantil, Educación Primaria.
Team payroll, pitcher and hitter payrolls and team performance: Evidence from the U.S. Major League Baseball
Authors: Lu Xing , Matthews Jason , Wang Miao , Zhuang Hong
Published: November 2018

We use the U.S. Major League Baseball team level data in 1985-2015 and find an inverse U-shaped relationship between team payrolls and winning percentages. Furthermore, when investigating the winning effects of pitcher and hitter payrolls, we find the similar curvilinear relationship between pitcher/hitter salaries and team performance.