bluuebunny/crossref_metadata_2025 huggingface dataset:
Anatomy of Infraorbital Foramen: Influence of Sex, Side, and Cranium Size
Authors: Gibelli Daniele , Borlando Alessia , Barni Luisa , Sartori Patrizia , Cappella Annalisa , Pucciarelli Valentina , Cattaneo Cristina , Sforza Chiarella
Published: March 2019

Several researchers have analyzed the collocation of infraorbital foramen, but no study has so far considered the possible influence of cranial size.

Three measurements (distances from anterior nasal spine, inferior orbital rim, angle at the intersection between the line from anterior nasal spine and the transversal plane parallel to the Frankfurt plane) were taken on 100 skulls belonging to a contemporary skeletal collection. In addition, maximum cranial length, maximum cranial breadth, cranial height, and bizygomatic breadth were measured, together with 2 indices (horizontal cephalic index and Giardina Y-index). Differences according to sex and side were assessed through 2-way analysis of variance test (P <0.05). Measurements showing statistically significant differences according to sex were further assessed through 1-way analysis of covariance test including cranial measurements and indices as covariates (P <0.05).

Statistically significant differences according to sex and side were found respectively for the distance from anterior nasal spine and the angle at infraorbital foramen (P <0.05). One-way analysis of covariance test verified that the sexual dimorphism of infraorbital foramen- anterior nasal spine distance was independent from the general measurements of cranium.

The present study first proved that sexually dimorphic parameters useful for the localization of infraorbital foramen do not depend upon the cranium size.
Autologous Fat Transfer for Facial Augmentation: Surgery and Regeneration
Authors: Clauser Luigi , Zavan Barbara , Galiè Manlio , Di Vittorio Leonardo , Gardin Chiara , Bianchi Andrea Edoardo
Published: March 2019

Autologous fat transfer (AFT) is a well-established and safe surgical technique in which autologous fat tissue is injected at a defective site directly after its harvesting and centrifugation. Initially used as an excellent filler for facial enhancement and rejuvenation, AFT has evolved over the years into more complex reconstructive procedures. Autologous fat transfer is now additionally used for correcting and restoring cranial and maxillofacial volume defects resulting from traumas, tumors, or congenital disorders. Apart from being a natural filler, human adipose tissue represents a rich source of mesenchymal stem cells, called adipose-derived stem cells, that exhibit multilineage differentiation potential and secrete several angiogenic and antiapoptotic factors.

In this work, the authors will discuss different aspects influencing the final outcome of AFT, on the basis of the major clinical outcomes obtained using this surgical procedure. Starting from preoperative evaluation and planning, donor–recipient sites, and type of anesthesia and infiltration, the discussion will continue by analyzing the methods of adipose tissue harvesting, purification, and processing. Finally, an overview of the type of placement, clinical application, postoperative care, possible complications, fat graft take, longevity, volume maintenance, and future perspectives will be provided.
Radio-Morphometric Evaluation of Greater Palatine Canal and Pterygopalatine Fossa Component: Maxillary Anesthetic Implications
Authors: Duruel Onurcem , Kulkarni Varun , Ataman-Duruel Emel Tuğba , Tözüm Melek Didem , Tözüm Tolga Fikret
Published: March 2019

This is a retrospective analytical cross-sectional study involving 131 cone-beam computed tomography (CBCT) scans of adult (18–99 years) that assessed greater palatine canal (GPC) attributes (length, curvature angle, diameter of curvature) and the type of the trajectory of GPC-pterygopalatine fossa (PPF) component. The GPC is an important landmark that connects the oral cavity and PPF. It contains greater and lesser palatine nerves, along-with descending palatine artery and vein by extending from the inferior part of the PPF to the hard palate. The GPC acts as a pathway for infiltration of local anesthesia. The inferior orbital fissure (IOF) is in close proximity to these vital anatomic structures and hence accurate identification of its location during regional block anesthesia is crucial. This is one of the very few studies investigating these important structures on CBCT scans highlighting the importance of preoperative scans for the anatomic determination. The images were analyzed for the lengths and anatomic paths of the right and left GPC-PPF in sagittal plane. The diameters of the upper (higher bony aspect of PPF) and lower openings (GPC opening) displayed statistically significant differences in the comparison between males and females (P < 0.05). Overestimation or underestimation of the GPC length can cause a lack of anesthesia and undesirable diffusion of the anesthetic solution into the orbit thorough the IOF causing diplopia, or into the cranial cavity. A thorough understanding of GPC length and pathway types is obligatory for proper anesthetic administration and performing any maxillofacial procedures.
Alar Rim Reconstruction With Autologous Graft Cartilage: External Approach
Authors: Orlando Guerrissi Jorge , Marquez Esteban
Published: March 2019

Alar deformities are frequently sequels of the incorrect primary rhinoplasties. Malpositions and irregular cartilage as consequence of either inadequated or exaggerated resection are the skeletal representation not only of aesthetic deformities but also collapse or depression, airway obstruction, valve narrowing by scarring, etc. Replace of alar cartilage is mandatory and many techniques have been described using autogenous cartilage graft since either ear or costal areas. Basically, a pocket must be made inside the thickness of ala permitting the placement of the graft. In our experience the placement of the graft was made by an incision in the fold in the base of the ala and a wide and net alar undermining, carving a pocket was carried out until the tip by means of sharp dissection with the scalpel, permitting the placement of the graft “like a sandwich.” The reason for this publication is to describe a surgical technique that permits an exact and correct placement of the graft obtaining the recuperation of normal shape, form projection, and functionality of the ala. The external alar incision is conspicuous and it remains hiding inside natural fold in the alar base.
The Future of Facial Fat Grafting
Authors: Brooker Jack E. , Rubin J. Peter , Marra Kacey G.
Published: March 2019

Fat grafting was first described in the early 20th century but for many years remained a relatively underused technique due to the unreliability of long-term volume expansion. Significant improvements in reliability have been made in the last 2 decades and there is a large body of literature pertaining to extraction, processing and injection methods to obtain more lasting effects. However, volume loss and graft resorption remain a major challenge in the long term and lead to unpredictability in results. Enriching adipose graft with stromal vascular fraction, ex vivo cultured adipose stem cells and platelet-derived growth factor among others is one method under active investigation which may assist graft survival through a range of mechanisms including increased angiogenesis. Breaking adipose graft into smaller fragments such that engrafted cells have greater access to donor-site oxygenation and nutrition is another method which in theory may promote survival. Presently, adipose grafting in the face is usually for the addition of volume to fill defects. However, the stem-cell containing fraction of adipose grafting (stromal vascular fraction) appears to exert a rejuvenating effect on overlying skin and soft tissue when administered alone. The application of these low-volume injections represents a significant shift in thinking away from mere volume expansion. These techniques have been tested in a range of animal models and some human studies. In this review, the authors provide a broad overview of present research and highlight both limitations in previous research and current areas of investigation.
The Influence of the First-Stage DO Treatment of Palate Defect on Growth of Maxilla
Authors: Liu Shiqi , Wang Hui , Zhou Nuo , Yang Lianghui , Fang Fang , Zhang Chong , Mai Huaming
Published: March 2019

To study the influence of distraction osteogenesis (DO) on the maxillary growth as first-stage treatment of palatal defect. The uniform palate defect experimental animal models (21 miniature pigs) were established surgically. Then animals were randomly divided into negative control group (A, n = 6), conventional surgery group (B, n = 6), and distraction osteogenesis group (C, n = 9) respectively. The group A underwent none treatment as control group, the group B were undergoing a conventional defect repair surgery, and the group C were undergoing a distraction osteogenesis treatment. Cone beam computed tomography examination was performed monthly to analyze the growth of maxilla for 6 months. One pig of group C was randomly sacrificed at 2, 4, and 8 weeks after the completion of DO and the tissue of distraction gap was stained with hematoxylin–eosin and Masson staining. At the end of 6th months, all pigs were sacrificed and tissues of the surgical area were stained as previous described. The palate defect was repaired by the distraction osteogenesis with the successful bone formation on the distraction gap. Group A and group C kept a similar growth rate, but that of group B was relatively slow. Distraction osteogenesis is efficient and successful for closing the defect of palate and there is no significant disturbance on the subsequent growth of the maxilla.
Enucleations and Eviscerations for Combat Ocular Trauma Performed During Operations Iraqi and Enduring Freedom: 2001 to 2011
Authors: Stevens Bryan J. , Justin Grant A. , Reed Donovan S. , Jaksha Alexandria F. , Davies Brett W. , DeMartelaere Sherri L. , Ryan Denise S. , Weichel Eric D. , Colyer Marcus H.
Published: March 2019

Purpose:

To describe the demographics and clinical outcomes of patients who underwent posttraumatic enucleation or evisceration during Operations Iraqi Freedom (OIF) and Enduring Freedom (OEF) from 2001 to 2011.

Methods:

The Walter Reed Ocular Trauma Database is a retrospective case series of US Servicemembers and Department of Defense civilians who had combat ocular injuries in OIF and OEF. Data regarding posttraumatic enucleations and eviscerations performed during OIF and OEF were extracted. The main outcomes analyzed were the number of enucleations and eviscerations performed, location of the surgery, laterality, and graft type. The secondary outcome measures included: mechanism of injury and Ocular Trauma Score classification.

Results:

One hundred nine enucleations and eviscerations were performed on the 890 eyes (12.24%). Sixty-three (57.80%) primary enucleations, 36 (33.03%) secondary enucleations, 5 (4.59%) postretinal detachment repair enucleations, and 5 (4.59%) primary eviscerations were completed. The surgeries were completed at a combat support hospital (57; 52.3%), or Walter Reed Army Medical Center (49; 45.0%). All surgeries were unilateral except in 2 patients. The most common graft type used was silicone (n = 56; 51.38%). Improvised explosive devices caused 76 (69.72%) eye injuries. Ocular Trauma Score were recorded as 56 (51.38%) between 0 and 44, 44 (40.37%) between 45 and 65, and unknown in 9 (8.26%).

Conclusion:

Posttraumatic enucleation or evisceration due to devastating ocular trauma is required in about 15% of ophthalmic patients in modern combat trauma. The psychosocial impact on veterans who have required an enucleation or evisceration from combat trauma has been poorly studied and requires further review.
Face Dissection as the Plastic Surgery Approach: Effective Method in Residency Training
Authors: Jung Joo Sung , Kang Dong Hee , Lim Nam Kyu
Published: March 2019

Purpose:

The global trend of resident work-hour restrictions requires a more time efficient way of resident training. Among many training programs for learning the facial anatomy, the cadaver is the most similar to live patients. A cadaver should be used as efficiently as possible due to human dignity as well as the consideration of cost. The authors designed an effective cadaver dissection method in learning facial anatomy using the plastic surgery approach.

Method:

A 51-year-old male cadaver was used for dissection. The program was proceeded 6 times over 6 weeks, and 4 to 8 hours each day. We used standard surgical instruments with magnifying loupes. The results were analyzed through a numerical scale survey.

Result:

We planned to dissect the face from medial to lateral, cephalic to caudal, and superficial to deep portion. The overall knowledge and confidence level of the face were increased in all 7 participants. The mean knowledge level before and after the seminar was 3.00 and 4.03, respectively. Confidence level also increased through the seminar from 1.86 to 2.86.

Conclusion:

The authors believe this cadaver dissection program could optimize learning anatomical knowledge and improve resident's surgical confidence through a wide range of procedures.
The Impact of Harvesting Systems and Donor Characteristics on Viability of Nucleated Cells in Adipose Tissue: A First Step Towards a Manufacturing Process
Authors: Papadopulos Nikolaos A. , Wigand Sylvia , Kuntz Nicolas , Piringer Marion , Machens Hans-Günther , Klüter Harald , Bieback Karen , Karagianni Marianna
Published: March 2019

Adipose tissue contains an abundant population of mesenchymal stromal cells (= adipose stromal cells [ASC]) with multilineage differentiation, immunomodulatory and trophic potential promising for cell-based therapies. Although intensely investigated in pre- and clinical studies, little is known about the impact of donor characteristics on the viability of ASC. To correlate patient data to the quality of processed adipose tissue and to establish a first step towards a manufacturing process for cell therapy, we evaluated the effects of 2 harvesting systems (LipiVage, TTF-System) and donor characteristics on cell viability of nucleated cells in a cohort of 44 samples obtained from 17 donors.

The impact of donor-specific factors (localization, age, body-mass-index, chronic diseases, intake of drugs, nicotine consumption or disorders of the thyroid gland) and the harvesting system on nucleated cell (NC) counts and viability of processed lipoaspirates were statistically analyzed.

Increasing age has a significant positive influence on NC viability (P = 0.001). Donors with intake of thyroid hormones based on a hypothyroidism and suctioned with the LipiVage-System reached a significantly higher viability of NC (P = 0.038). No statistical difference was shown between the 2 harvesting-systems (P = 0.338) and the donor sites (P = 0.294).

We focused on a potential correlation between NC viability and donor characteristics. Based on the donor cohort investigated in this study, cells from elderly patients suctioned with the LipiVage-System and taking thyroid hormones yielded cells of higher viability, suggesting an improved quality for subsequent manufacturing procedures. Further investigations are necessary to understand and correlate this data to ASC in vitro characteristics.
Soft Tissue Reconstruction in Patients With Hemifacial Microsomia: A Systematic Review of the Literature
Authors: Sinclair Nicholas , Gharb Bahar Bassiri , Papay Francis , Rampazzo Antonio
Published: March 2019

Introduction:

Hemifacial microsomia is the most common congenital disorder of the face after cleft lip and palate. While treatment of the bony abnormalities has been well documented, less attention has been paid to correction of the soft tissue deformity. This study aimed to systematically review the literature addressing the techniques utilized to correct the soft tissue deformity in hemifacial microsomia.

Materials and Methods:

A comprehensive review of peer-reviewed literature regarding the management of soft tissue reconstruction in patients with hemifacial microsomia was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses statement. Odds ratio was used to assess differences in complication rates between reconstructions performed with free tissue transfer and fat grafting.

Results:

The literature search yielded 38 articles that were fully reviewed for data extraction. Articles were grouped into one of 5 reconstructive modalities—pedicled flap, microvascular free tissue transfer, structural fat grafting, alloplastic implant, and functional reconstruction. Microvascular free tissue transfer had a complication rate of 27.1%, while structural fat grafting had a complication rate of 4.2% (odds ratio 6.7, P 
= 0.0003).

Conclusions:

Microvascular free tissue transfer likely provides greater volume than fat grafting at the cost of a higher complication rate. Mild to moderate soft tissue deformity can be corrected with serial fat grafting. However, severe soft tissue deformity is better corrected with microvascular free tissue transfer. When performing free tissue transfer, one should be prepared for recipient vessel anomalies. To provide adequate augmentation with isolated fat grafting, multiple sessions are likely required.
Polymorphous Low-Grade Adenocarcinoma: A Proposed Reconstruction Protocol Based on Past Surgical Experience
Authors: Gottlieb Jonathan B. , Joachim Michael , Leiser Yoav , Abdelraziq Murad , Abu El-Naaj Imad
Published: March 2019

Background:

To propose a reconstructive protocol based on surgical management experience of polymorphous low-grade adenocarcinoma (PLGA) and the location of the primary lesion.

Methods:

Data on the surgical management and the reconstructive technique of 14 histologically conformed patients with PLGA, all treated by the same surgeon, were analyzed and evaluated.

Results:

Mean follow-up period in our series was 6.2 years. Mean age at diagnosis was 55.5 years and female to male ratio was 2.2:1. The most common presenting sign was a nonpainful lump or mass in an intraoral location. Most patients were managed by wide local excision and reconstruction method varied from primary closure to the use of radial forearm graft. Recurrence appeared in one of the patients in this series, while 2 required further radiation therapy. A protocol for reconstruction of intraoral patients with PLGA is suggested based on our analysis.

Conclusion:

Surgical management is the gold standard for PLGA treatment. Neck dissection is recommended only in patients with presurgery fine-needle aspiration confirmed lymph node involvement. The reconstruction depends mainly on location and size of the primary lesion.
An Automatic Spatial Registration Method for Image-Guided Neurosurgery System
Authors: Fan Yifeng , Yao Xufeng , Hu Tingting , Xu Xiufang
Published: March 2019

Objective:

This study aimed to investigate the feasibility of an automatic marker-free patient-to-image spatial registration method based on the 4-points congruent sets (4PCS) and iterative closest point (ICP) algorithm for the image-guided neurosurgery system (IGNS).

Methods:

A portable scanner was used to obtain the point cloud of the patient's entire head. The 4PCS algorithm, which is resilient to noise and outliers, automatically registered the point cloud in the patient space to the surface reconstructed from the patient's preoperative images in the image space without any assumptions about initial alignment. A variant of the ICP algorithm was then used to finish the fine registration. Two phantoms and 3 patients’ experiments were performed to demonstrate the effectiveness of the proposed method.

Results:

In the phantom experiments, the mean target registration error of 15 targets on the surface of the rigid and the elastic phantoms were 1.02 ± 0.18 mm and 1.27 ± 0.36 mm, respectively. In the clinical experiments, the mean target registration error of 7 targets on the first, second and third patient's head were 1.88 ± 0.19 mm, 1.84 ± 0.19 mm, and 1.89 ± 0.18 mm, respectively, which was sufficient to meet clinical requirements. The registration accuracy and registration time using the proposed method are better than that using the method based on manually coarse registration and automatic fine registration.

Conclusions:

It is feasible to use the automatic spatial registration method based on the 4PCS and ICP algorithm for the IGNS. Moreover, it can replace the spatial registration method based on manually selected anatomical landmarks combined with the automatic fine registration in the currently used IGNS.
Effectiveness of a Piezoelectric-Assisted Distraction Osteogenesis Procedure for the Treatment of Ankylosed Permanent Front Teeth
Authors: Ramaglia Luca , Cicciù Marco , Fiorentino Emilio , Saviano Raffaele , Blasi Andrea , Cervino Gabriele , Isola Gaetano
Published: March 2019

A common complication of tooth replantation after traumatic avulsion is tooth ankylosis causing dental malpositioning, partial loss of function, tipping of adjacent teeth and worsening of aesthetics. The aim of this study is to evaluate the effects of a repositioning procedure of such ankylosed permanent front teeth by a distraction osteogenesis procedure. Five patients (mean age 13.4 years), with an ankylosed permanent front tooth in the anterior area, were enrolled in the present study. After the pre-operatory orthodontic preparation, each selected site was treated with single-tooth dento-alveolar block osteotomy surgery performed with a piezoelectric surgery device with ultrasonic cuts on the buccal side. Subsequently, a custom distraction device, made by a resin splint and a sector expansion screw, was set in such a way it delivered a force with direction and sense towards the planned position of the tooth as well as the osteotomy's incision. After a latency period of 14 days, the distraction of the dento-alveolar block was started with a rate of distraction of 0.8 mm per day. The average shift obtained by the ankylosed teeth was 7.8 ± 0.75 mm (±SD), and the ankylosed tooth was regularly positioned into the occlusion in 20.4 ± 1.85 days (±SD), with a slight relapse (±0.5 mm) observed after 1 year. This study indicates that a therapeutic approach combining piezoelectric surgery and orthodontic therapy may be useful for the treatment of ankylosed permanent teeth in the frontal area with a long-term follow-up over 5 years.
Alternative Therapies to Fat Grafting in the Craniofacial Region
Authors: Yoo Jason J. , Casey Liann C. , Herweck Alexandra M. , Thaller Seth R.
Published: March 2019

Autologous fat grafting is a technique with various applications in the craniofacial region ranging from the treatment of wounds, scars, keloids, and soft tissue deformities. In this review, alternative therapies to fat grafting are discussed. These are composed of established therapies like silicone gel or sheeting, corticosteroids, cryotherapy, and laser therapy. Novel applications of negative pressure wound therapy, botulinum toxin A injection, and biologic agents are also reviewed.
Parents’ Knowledge, Attitude and Behaviour toward Cleft Lips and Cleft palate in Kencana Hospital, Serang, Banten
Authors: Soeselo Daniel Ardian , Suparman Alexandria Stephanie , Budi Agus Santoso
Published: March 2019

Introduction:

Cleft lips (CL) and cleft palate (CP) are common congenital diseases caused by gene mutation in embriology development of the lips and mouth at 4 weeks of gestation. CL and CP can cause several problems such as difficulty in eating, speaking, abnormality in teeth and mouth development and ear iritation. Adequate treatment is needed to improve patients’ quality of life.

Material and Method:

This cross sectional study take samples purposively from all parents who joined in cleft charity surgery in Kencana Hospital, Serang, Banten on October 24th 2018. This study identify parents’ knowledge, attitude and behaviour towards CL and CP and analyzed the relationship of parents’ knowledge and attitude towards CL and CP. Statistical analysis used in this study is Fisher method.

Result:

Ten patients undergo labioplasty surgery, 1 patient undergo labioplasty revision, 5 patients undergo palatoplasty surgery and 10 patients undergo labioandpalatoplasty surgery. The majority of parents’ education background have income < 3,5 million a month 84.6% (22 people), do not have any social insurance 88.5% (23 people) and joined in because of they cannot pay for medical treatment 96,2% (25 people). 6.2% (25 people) have under knowledge, 69.2% (18 people) have good attitude and 84.6% (22 people) have good behaviour toward CL and CP. There is no significant relationship between parents’ knowledge and attitude toward CL and CP P value = 1,00 (P > 0,05).

Discussion:

Parent's under knowledge is caused by their low educational background and inaccurate information and education provided by medical professional. But, they had a good attitude and behaviour toward CL and CP because they had initiative to look for medical help and treat their children same as other normal one. Although they received inaccurate information and education about cleft disease, all parents looked for medical help and did what they were told by medical professionals.

Conclusion:

The majority of parents in this study have under knowledge about cleft lips and cleft palate but they are still looking for medical help to treat their children. This charity significantly helps parents whose children have cleft lips, with or without cleft palate, to get treated in that area.
Evaluation of the Accuracy of Virtual Planning in Orthognathic Surgery: A Morphometric Study
Authors: Zavattero Emanuele , Romano Michele , Gerbino Giovanni , Rossi Diego Sergio , Giannì Aldo Bruno , Ramieri Guglielmo , Baj Alessandro
Published: March 2019

Background:

The purpose of this study was to prospectively test the accuracy of computer-aided orthognathic surgery comparing the virtual surgical planning with the three-dimensional (3D) outcome.

Methods:

Patients that underwent computer-assisted orthognathic surgery were retrospectively evaluated. The postoperative results were compared with the surgical plan, superimposing the postoperative computed tomography (CT) scan onto the virtual plan. Surface-based superimpositioning of the postoperative CT scan onto the 3D preoperative plan was carried out to visualize the discrepancy between preoperative virtual plan and postoperative 3D CT result.

Results:

A total of 17 consecutive patients that underwent two-jaw computer-assisted orthognathic surgery were enrolled in the study.

The average linear differences for selected points were <1 mm in 12 patients out of 17. In 5 patients out of 17, the average differences for selected points were <2 mm.

Conclusions:

An overall high degree of accuracy between the virtual plan and the postoperative result was found.
Fat Grafting in Orthognathic Surgery
Authors: Iyengar Rajiv J. , Gabrick Kyle , Bruckman Karl , Steinbacher Derek M.
Published: March 2019

Background:

Fat grafting is widely utilized in craniofacial surgery. The authors describe a series of consecutive patients who underwent orthognathic surgery with fat grafting by the senior author and review relevant literature in the field; fat grafting technique is discussed in detail. The authors also highlight 3 patients to illustrate postoperative outcomes.

Methods:

A retrospective cohort of consecutive orthognathic surgery patients was reviewed. Age, sex, BMI, procedure, area of harvest, location of injection, donor site complications, and need for repeat fat grafting were analyzed. Inclusion criteria included history of orthognathic surgery and concomitant fat grafting performed by the senior author in 2015.

Results:

Fifty-three orthognathic surgery patients with concurrent fat grafting were reviewed. The cohort comprised 20 males (37.7%) and 33 females (62.3%). Thirty-three patients (62.3%) underwent Le Fort I operations either in conjunction with genioplasty and/or bilateral sagittal split osteotomies. Twenty-eight patients (52.8%) underwent second operations involving additional fat grafting. The majority of these patients (15/28, 53.6%) received additional fat grafting during ensuing rhinoplasty. There were no donor site complications (ie, infection, wound breakdown) recorded in the authors’ patient cohort. Amount of fat injected averaged 13.1 cc (range 5–25 cc). Follow-up generally occurred through the 1-year mark.

Conclusions:

Fat grafting is a proven technique to facilitate optimal postoperative wound-healing in orthognathic surgery. The senior author uses Telfa processing and the Coleman system to deliver the fat atraumatically. The authors’ cohort of consecutive patients corroborates the benefits of fat grafting in craniofacial surgery; the authors observe wound-healing benefits, enhanced aesthetic outcomes and an anti-inflammatory effect with this technique.
A Giant Cervical Lymphangioma
Authors: Demirag Evman Melis , Aydin Sedat
Published: March 2019

Cervical lymphangiomas are benign congenital malformations of lymphatic system usually seen in children under 2 years of age. It is rare in adults. They can be seen in any part of the body but the most common area in the neck region is posterior triangle. They usually present as asymptomatic masses. There are various ways of treatment, but the most common treatment modality is surgical resection. Here, the authors present a giant lymphangioma in the neck region of an adult who is treated with surgical resection without any complication.
Minimally-Invasive Endoscopic-Assisted Sinus Augmentation
Authors: Giovannetti Filippo , Raponi Ingrid , Priore Paolo , Macciocchi Antonio , Barbera Giorgio , Valentini Valentino
Published: March 2019

Objectives:

The purpose of this article is to evaluate endoscopic-assisted technique by lateral approach for sinus floor augmentation, to reduce the incidence of Schneiderian membrane perforation, and to guarantee a sufficient apposition of new bone even in the posterior maxillary sinus.

Methods:

From January 2017 to December 2017, 10 patients affected by severe maxillary atrophy underwent endoscopic-assisted sinus augmentation using a lateral approach.

Results:

In only 1 patient, a little perforation of sinus membrane was observed intraoperatively and it was repaired. No abnormal postoperative bleeding was observed. None of the patients experienced oro-antral fistula, infection, or V2 dysesthesia. The authors did not find radiologic evidences of biomaterial displaced on the maxillary sinus or postoperative sinusitis.

Conclusions:

The authors evaluated endoscopic-assisted maxillary sinus augmentation technique using a lateral approach that allows a direct and clear view of the surgical field. This technique, as the preliminary results demonstrate, is safe and helpful, especially in avoiding membrane perforation and in xenograft optimal distribution. It could be very useful in retreatment patients.
Comparative Biological Effects of Human Amnion and Chorion Membrane Extracts on Human Adipose-Derived Stromal Cells
Authors: Namgoong Sik , Lee Hyunsu , Lee Jae-Sun , Jeong Seong Ho , Han Seung-Kyu , Dhong Eun-Sang
Published: March 2019

Although therapies with human amnion/chorion are used to ameliorate acute and chronic wounds, it is unclear which component of the amnion/chorion tissue promotes wound healing. To characterize the comparative effects of amnion and chorion in wound healing, we used human adipose-derived stromal cells to assess cell viability, migration, and gel contraction after treatment with amnion membrane extract (AME) or chorion membrane extract (CME). We then correlated the possible effectors via AME and CME protein profiling, and compared them by enzyme-linked immunosorbent assay (ELISA), western blotting, and immunocytochemistry. Cell viability was significantly increased with 50 and 100 μg/mL AME treatment, but with CME treatment, a significant increase was only observed with 100 μg/mL. With CME treatment, cell migration was 2.22-fold greater than the control, and collagen gels showed 20% greater contraction. Compared to control, the expression levels of α-smooth muscle actin (SMA) and smooth muscle protein 22-alpha (SM22α) increased both with AME and CME treatments, whereas calponin expression decreased. Protein profiling revealed significantly higher tissue inhibitor of metalloproteinase-1 (TIMP-1), interleukin-8, exotoxin, and adiponectin levels in CME than in AME, and ELISA revealed 8-fold higher adiponectin levels in cells treated with CME than those treated with AME. Immunocytochemistry revealed that α-SMA, SM22α, and calponin were significantly higher in CME- than AME-treated cells; however, adiponectin treatment did not enhance α-SMA, SM22α, or calponin expression. In conclusion, amnion and chorion membrane extracts exerted differential effects on proliferation and contraction of human adipose-derived stromal cells. Amnion extract was superior at inducing cell proliferation and migration, whereas CME was superior at inducing cell contraction.
Saccular Aneurysm of the Internal Jugular Vein in an Adult Patient and Its Surgical Treatment
Authors: Ozturk Murat , Yavuz Sadan , Durmus Kasim , Rahimli Fidan
Published: March 2019

Objectives:

Congenital jugular vein aneurysm in an adult patient is a rare condition.

Clinical Report:

A 17-year-old patient presented to the authors’ clinic with left neck swelling. The clinical and radiological findings were appropriate with the internal jugular vein aneurysm. The authors detailed their experience in the surgical treatment of this true saccular aneurysm.

Conclusion:

Jugular venous aneurysm is a rare benign venous pathology and it can be easily confused with other neck pathologies. Its surgical excision can be sometimes difficult and troublesome than expected.
Effect of a Superior Lateral Anterior Pedicle Flap for Draf Procedures
Authors: Omura Kazuhiro , Nomura Kazuhiro , Aoki Satoshi , Tochigi Kosuke , Miyashita Keisuke , Tanaka Yasuhiro , Otori Nobuyoshi , Kojima Hiromi
Published: March 2019

Several types of flap techniques have been developed to cover exposed bone after Draf procedures to reduce the possibility of re-stenosis. These techniques are relatively new and detailed measurements of the size of neo-Ostia during follow-up have not been reported. The authors aim to assess outcomes precisely by not only using endoscopic evaluation but also by measuring the diameter of the ostium and the thickness of the nasal beaks on pre- and postoperative computed tomography images. The authors reviewed 25 patients with 37 nasal cavities who have undergone a Draf surgery with a previously-reported superior lateral anterior pedicle flap technique. The anteroposterior (AP) distance of the frontal recess and the thickness of the nasal beaks were measured before, immediately after, and more than 6 months after surgery. Measured distances were statistically analyzed. The neo-ostium remained patent in long-term follow-up of all patients. The AP distance of the frontal recess and the thickness of the nasal beak were preserved during follow-up. Neither synechiae nor orbital injuries occurred. In conclusion, Draf type II and III procedures with superior lateral anterior pedicle flaps are safe and effective. Neo-Ostia remained patent throughout the follow-up period.
Does Orbital Volume Change Using the Mirror Technique Have a Correlation With Posttraumatic Enophthalmos?
Authors: Mohajerani Hassan , Jafari Seyed Mehrshad , Dehghanpour barouj Mehrdad , Manoochehri Negar , Tabrizi Reza
Published: March 2019

An increase in orbital volume (OV) is an important factor in posttraumatic enophthalmos. The aim of this study was to evaluate the correlation of OV change using the mirror technique with posttraumatic enophthalmos.

In this cross-sectional study, a 3-dimensional (3D) semi-automated volumetric method, using a 3D volume rendering tool, was applied to measure OV. The total orbital volume difference (TOVD), posterior orbital volume difference (POVD), and anterior orbital volume difference (AOVD) were measured as predictive factors in traumatic and intact orbits. Enophthalmos was also examined as the outcome, using a Hertel exophthalmometer.

A total of 27 patients were examined in this study. The mean TOVD was 4.48 ± 1.82 mm3, the mean POVD was 1.91 ± 0.31 mm3, and the mean AOVD was 2.57 ± 1.71 mm3; also, the mean enophthalmos was 2.89 ± 1.12 mm. Pearson's correlation test demonstrated a positive correlation between enophthalmos and TOVD, POVD, and AOVD (P <0.05). Based on the linear regression model, TOVD had a predictive power of 61.7% for enophthalmos. For every 1-mm3 volume change, a 0.38-mm enophthalmos was expected (R2, 0.617; B, 0.38; P = 0.001).

TOVD, POVD, and AOVD showed strong correlations with enophthalmos. However, it seems that POVD has the greatest effects on the occurrence of posttraumatic enophthalmos.
Three-Dimensional Displacement of Partial Craniofacial Bones Following Rapid Maxillary Expansion in Young Patients with Angle Class III Malocclusions
Authors: Liu Yifan , Feng Feng , Wang Yuqiao , Chi Jingwen , Liu Wen
Published: March 2019

Objective:

The aim of this study was to analyze the displacement in 3D direction of some craniofacial bones with the rapid maxillary expansion in Angle class III malocclusion.

Method:

Thirteen Angle class III patients (mean age: 12.4 ± 1.7 years; 7 males, 6 females) using rapid maxillary expansion as part of their orthodontic treatment were selected and computed tomography scans were taken before and after expansion. The 3D models were reconstructed using the Mimics software and the maxillary, zygomata, nasal bones were separated. With 3D models correction and registration, the displacements in the 3D directions of partial craniofacial bones were measured. Quantitative variables were analyzed by using SPSS19.0 and a t value less than 0.05 was considered statistically significant.

Results:

Measurement results showed that rapid maxillary expansion produced significant displacement in both sides of the maxillary, zygomata, and nasal bones. In the width of the midline palatine suture, the anterior nasal spine point was expanded a mean 4.18 mm (range 2.42 mm–5.68 mm, P
left = 0.007, P
right = 0.014) and the posterior nasal spine point was expanded a mean 2.14 mm (range 1.96 mm–2.43 mm, P
left < 0.001, P
right = 0.002). In the width of the maxillary in coronal plane, the Spr point was expanded a mean 4.86 mm (range 3.34 mm–6.22 mm, P
left = 0.004, P
right = 0.008) followed by the A point expanded a mean 4.47 mm (range 2.87 mm–5.97 mm, P
left = 0.005, P
right = 0.010). The bilateral maxillary moved to both sides and the points of the front maxillary anterior nasal spine and A moved forwards and downwards. In the width of the zygomata, the Zm point was expanded 2.18 mm (range 1.87 mm–2.41 mm, P
left = 0.001, P
right = 0.002) on average and moved backwards, the retral and upper points of the zygomata Za and Mz also moved backwards. The points Zm, Za, and O all moved upwards. The external lateral side of the nasal bone expanded to both sides, the Ipa point was expanded a mean 2.04 mm (range 1.11 mm–2.46 mm, P
left = 0.008, P
right = 0.019) and the centre of the nasal bone moved backwards and downwards.

Conclusion:

With rapid maxillary expansion, the increasement of width in the maxillary affected the position of the zygomata and nasal bones in the 3D directions, caused changes in facial appearance.
Preservation of Autogenous Septal Cartilage for Revision Surgery
Authors: Sari Hüseyin , Hanci Deniz , Sari Bahar , Kumral Tolgar Lütfi , Gurpinar Berk , Tanrisever Onur , Akgun Muhammed Fatih , Arslanoğlu Ahmet , Yildirim Guven , Uyar Yavuz
Published: March 2019

The aim of this study is to find the ideal solution and the optimum temperature to protect the viability of the cartilage graft. This randomized prospective study consists of 30 patients with septal deviation. All patients had septoplasty operation for chronic nasal obstruction. Ten strips of cartilages were prepared from each excised septum and then immersed in formalin, alcohol (96%), saline (0,9%), gentamicin (80 mg), and cefazolin sodium (Cezol 1gr) solutions in a total of 300 vials. Those vials were stored for 6 months at both +4°C and −18°C temperatures. Two groups were compared with each other. 22 cases were male (73%) and 8 patients were female (7%). The age range was between 20 and 48 (average 25.34 ± 4.09 years). Parameters at +4°C; the cartilage volume was not significantly different among the solutions (P >0.05). Necrosis was significantly lower in the alcohol (46.7%) compared to other solutions (P = 0.001). Calcification was lower in the gentamicin group (56.7%). The loss of metachromasia was lower in the alcohol solutions (P = 0.000). Parameters at −18°C; the loss of metachromasia was higher in the gentamicin group (56.7%) than the other solutions (P = 0.003). The authors observed no significance in the rates of necrosis, calcification, metaplasia, inflammation, vascularity, or fibrosis among the solutions (P >0.05). Less necrosis and metachromosis loss in the alcohol solution indicated that alcohol was more suitable for preservation of the cartilage. In addition, temperature degree for the preservation of the cartilage did not show any significant differences.
Difference in Degrees of Satisfaction with Orthognathic Surgery and Orthodontic Treatment between Skeletal Class III and Cleft Patients
Authors: Yim Sunjin , Baek Seung-Hak
Published: March 2019

Objective:

The aim of this study was to compare the degrees of satisfaction with orthognathic surgery and orthodontic treatment between skeletal Class III and cleft patients.

Materials and Methods:

The samples consisted of Class III group (N = 25) and Cleft group (N = 16). The Modified Orthognathic Quality of Life Questionnaires, which had 5 domains (oral function [OF], awareness of dentofacial deformity [ADD], social relationship [SR], facial esthetics [FE], and nose/lip esthetics [NLE]), were evaluated with 5 rates (0 [very satisfactory] to 4 [very unsatisfactory]) at initial visit (T1), just before surgery (T2), 3 to 6 months after surgery (T3), and at debonding or 1 year after surgery (T4). The scores at each stage, amount of change between stages, and effect size (ES) in the 5 domains were investigated.

Results:

Compared to Class III group, Cleft group exhibited lower satisfaction scores of NLE domain during all stages (all P < 0.001) and of SR domain and total domains at T4 stage (P < 0.05, P < 0.01). Cleft group showed significant improvement of satisfaction scores in FE domain during T1-T2 (P < 0.01), in SR, FE, NLE, and total domains during T2-T3 (all P < 0.01), in OF, SR, and total domains during T3-T4 (P < 0.05, P < 0.01, P < 0.01), and in all domains during T1-T4 (ADD, P < 0.05; OF, SR, and NLE, P < 0.01; FE and total, P < 0.001). Cleft group exhibited large improvement of ES only at SR and FE domains during T2-T3 (−0.81 and −1.09, respectively).

Conclusions:

Owing to lower satisfaction of NLE domain at all stages in cleft patients, clinicians should recommend adjunctive cosmetic surgery for nose and lip after completion of treatment.
Unexpected Intracranial Hemorrhage and Death After Cranioplasty in a Patient With Massive Hemispheric Infarction
Authors: Wen Guodao , Zeng Peng , Zhou Jinyao , Wang Guangbing , Wu Guiping , Zeng Wensheng , Zhou Dan
Published: March 2019

The benefits and common complications of cranioplasty are often mentioned, but fatal complications are rarely documented. Here, the authors report a patient of intracranial hemorrhage and death after cranioplasty and discussed the possible mechanism. A 42-year-old man was admitted with the diagnosis of massive cerebral infarction in left fronto-temporo- parietal lobe, emergency surgery for decompressive large craniotomy and Encephalo-Myo-Synangiosis were performed. One year after surgery, cranioplasty was performed using a titanium mesh plate. Intraoperative cerebrospinal fluid leakage was occurred and dura mater was repaired using pieces of silk. During the postoperative anesthesia emergence, the patient had epileptic seizures and did not wake after surgery. The authors also observed about 150 mL bloody cerebrospinal fluid (CSF) in the subcutaneous vacuum drainage system within 2 hours. Emergency computed tomography of the brain showed epidural, subdural, subarachnoid hemorrhages in the postischemic area, the middle line left, and the brain stem swelling. The patient's family refused to immediately remove the titanium mesh plate. Finally, nonoperative treatment is invalid and the patient's neurological condition did not recover and he died 3 days after the surgery. In the authors’ mind, patients with previous massive cerebral infarction and Encephalo-Myo-Synangiosis undergoing cranioplasty might be at heightened risk of a fatal event than other cranioplasty. Therefore, the patients should be paid more attention to prevent and treat the fatal complications.
Guided Bone Regeneration Using BioGlue As a Barrier Material With and Without Biphasic Calcium Phosphate
Authors: Doganay Ozge , Tugrul Mehmet , Olgac Vakur , Atalay Belir
Published: March 2019

The aim of this study was to investigate the effects of Bioglue as a mechanical barrier with or without biphasic calcium phosphate (BCP) in a rat tibia model. Sixty Sprague Dawley male rats weighing 250 ± 20 g and 10 to 12 weeks of age were studied. Unicortical defects were created on the right tibia of all rats. Subjects were randomly divided into 3 groups. BioGlue group (24 rats); BioGlue alone, Graft group (24 rats); BioGlue + BCP and Control group; unfilled and uncovered (12 rats). Animals were euthanized at 7th, 21st, and 45th days postoperatively for histological and histomorphometric analyses. BioGlue material exhibited no adverse effects until the end of observation period. Bone-healing scores did not differ statistically between Control and BioGlue group, but found to be lower in Graft group on 21st and 45th days, (P < 0.001 andP < 0.01 on the 21st day andP < 0.01 andP < 0.05 on the 45th day, respectively). New bone formation in Graft group was found to be statistically different from Control group on the 7th and 21st days (P < 0.01 andP < 0.05 respectively), whereas no statistical difference was observed between BioGlue and Control group at all times. The present analysis indicates that BioGlue functioned well as a mechanical barrier allowing new bone formation. No additional benefit of combination treatment was detected in this study design and BCP did not offer any advantage for bone regeneration, thus it can serve as only a space maintainer.
The Importance of Serological Procalcitonin Levels After Autologous Microsurgical Transplantation
Authors: Safi Ali-Farid , Schröder Kai , Kauke Martin , Safi Sema , Zöller Joachim E. , Zinser Max
Published: March 2019

Introduction:

Published data on procalcitonin (PCT) levels after microsurgical interventions are very scarce, although infection within these patients is not only associated with severe morbidity but also significantly higher mortality rates.

Material and Methods:

Retrospective study on 20 patients, who were operated on by a single experienced plastic and reconstructive surgeon within one year (June 2017–June 2018). The authors included all patients, who received microvascular transplants for reconstruction of soft tissue defects. Furthermore, age above 18 years and appropriate documentation allowing sufficient data collection were defined as inclusion criteria. The authors excluded all patients with perioperative systemic inflammation and transplant loss, as our aim was to solely determine and evaluate potential alterations of serological PCT levels after microsurgical interventions.

Results:

The PCT cutoff level to differentiate physiological and pathological levels was defined as 0.1 μg/L. There was no detectable increase in procalcitonin in all of our 20 patients, for whom the authors performed microvascular transplantation to reconstruct soft tissue defects.

Conclusion:

Serological PCT levels remain stable after the considered surgical interventions and therefore PCT levels might be utilized to identify systemic inflammation, thus helping to reduce severe complications by early individualized antiinfective treatment strategies.