bluuebunny/crossref_metadata_2025 huggingface dataset:
AKIBAT HUKUM PENGANGKATAN ANAK TANPA PENETAPAN PENGADILAN
Authors: Safarianingsih Rini
Published: January 2025

An adopted child defines as a child’s rights are transferred from original parents, legal guardian, or other people who are responsible for the care, education, and nurturing of the child, into adoptive parents based on a decision or court order, as regulated in Article 1 Number 1 Government Regulation No. 54 of 2007 about the Implementation of Child Adoption.Children adoptions apply for both married couples and women or men who are single as long as they have a highly motivated to raise a child. In the process adoption, the prospective adoptive parents need a statement from the parents when handing over the child. Adoption of children hasbecome a practice among Indonesian people and has been taken up by religious and non-Islamic state judiciaries. Adoption does not break the blood relationship between the adopted child and his or her born parent. Section 6 (1) states that adoptive parents are obliged to notify the adoptive child of the birth and birth parent, and Section 6(2) takes into account the motivation of the child in question for birth and birth parent notification. moreover, adoption of a child is considered valid if a court decision is made and entered into the registry documents.
Implementación de hilos virtuales para mejorar la velocidad de procesamiento usando JAVA 21
Authors: Berrio Huamani Miguel Angel
Published: January 2025

La velocidad de respuesta en las aplicaciones es un factor muy importante a considerar, en ese sentido es importante considerar que las aplicaciones actualmente tienen muchos desafíos que considerar para poder obtener una buena velocidad de respuesta con la limitación de recursos con las que contamos.  Actualmente una solución que se ha brindado a fin de mejorar esto, es la programación paralela con ello se puede dividir una tarea en diferentes hilos de ejecución. Así también es importante indicar que la implementación de la programación paralela depende mucho de la tecnología usada, en así que Java en su versión 21 nos presenta una nueva interfaz con la creación de hilos virtuales los cuales rompen la limitante de la cantidad de núcleos del procesador con lo cual solo podíamos crear esa cantidad como un máximo de hilos disponibles, con ello se busca que tanto la velocidad, así como el rendimiento de los servicios tengan una mejora considerable.
Prospects of Application of Ultrashort Pulses Laser Sources in Medicine
Authors: Bogomolov V. M. , Sazonkin S. G. , Orekhov I. O. , Pershin K. B. , Tsygankov A. Yu. , Prosiannikov M. Yu. , Karasik V. E.
Published: January 2025

Purpose: This section reflects the level of influence of laser sources in reducing the harmful effects of various medical procedures, as well as in increasing their efficiency. Current trends of further reduction of the laser procedures invasiveness are analysed, and the method of reducing negative factors by decreasing the laser pulses duration is highlighted.
Analysis of the adverse effects of laser treatment in medical operations and procedures: The key factors of intra- and postoperative damage in laser surgery and procedures in urology, dermatology, ophthalmology and dentistry are analysed. The magnitude of these factors when using currently clinically available laser equipment is reflected.
Analysis of the possibility of reducing negative factors in subpicosecond and femtosecond laser operations and procedures: The dynamics of the same harmful factors and complications for similar medical procedures using subpicosecond and femtosecond laser radiation have been reviewed. A significant reduction in harmful factors and complications of their application is shown in comparison with the use of currently available medical laser systems.
Conclusion: The basic data on harmful factors reduction in urology, dermatology, ophthalmology and dentistry using laser sources with subpicosecond and femtosecond pulses are presented. Prospects for the implementation of laser systems based on ultrashort duration sources in various fields of medicine are considered.
The Impact of Digital Modernity on Administrative Performance in Saudi Universities
Authors: Al-Anzi Sami Hadwan Rashid , Toukabri Maher
Published: January 2025

The study aimed to assess the impact of digital modernity on administrative performance at Northern Border University, Saudi Arabia. The research involved 788 employees and a sample of 395 individuals. The study used a descriptive approach and SPSS program to analyze data. Results showed that the university's contribution to employee awareness of digital systems in administrative work was significant, with a mean of 4.41. However, there was a discrepancy around the axis of digital modernity. The study also found that digital transformation contributed to the development of administrative performance, with a mean of 4.07, indicating agreement. The advantages and constraints of digital modernity on administrative performance were also agreed upon. The study recommends meeting the needs of digital transformation and supporting the process to keep pace with global development.
Effect of Visionary Leadership on Team Innovation: Understanding Mediating Roles of Team Cohesion, Team Knowledge Collaboration and Team Bound-ary Management
Authors: Utomo Wahyu Abdillah , Tjahjono Heru Kurnianto , Qamari Ika Nurul
Published: January 2025

This study is important as it seeks to fill the existing gap in the existing literature on the interactions between visionary leadership and team innovation in the context of the palm oil industry which is confronted with the challenge of achieving profitability while operating in an environmentally sus-tainable manner. The study sets out to investigate the impact of visionary leadership on the innova-tion exhibited by the teams while focusing on team cohesion, team knowledge collaboration and team boundary management as the mediating variables. A quantitative explanatory design was adopted and data was collected from 280 respondents in nine palm oil factories in Rokan Hulu Re-gency, Riau Province, Indonesia. Databases include Structural Equation Modeling (SEM) Managed to achieve data processing and analysis of the relationships among the variables. The results show that anyway, visionary leadership is a strong contributor to team innovation, both directly and indi-rectly, through its principles such as teamwork, boundary management, and even collaboration. From these findings, it is critical to highlight that visionary leadership is key in enhancing the team work environment and the team collaboration potention which in the long run triggers innovation. Such management practices should focus on how to develop leadership that drives sharing of knowledge and boundary management as this improves the innovation capabilities of the firm.
AMPK-Mediated Multi-Organ Protective Effects of GLP-1 Receptor Agonists
Authors: Wang Xin , Wang Linxi
Published: January 2025

Review
AMPK-Mediated Multi-Organ Protective Effects of GLP-1 Receptor Agonists

Xin Wang 1 and Linxi Wang 2,*

1 Emergency Department, Fujian Medical University Union Hospital, Fuzhou 350001, China
2 Department of Endocrinology and Metabolism, Fujian Institute of Endocrinology, Fujian Medical University Union Hospital, Fuzhou 350001, China
* Correspondence: dr.linxi.wang@foxmail.com

Received: 11 October 2024; Revised: 23 October 2024; Accepted: 20 December 2024; Published: 9 January 2025

Abstract: AMP-activated protein kinase (AMPK) is a key enzyme broadly involved in regulating cellular metabolism, often called an “energy sensor”. Activated AMPK promotes ATP production and storage within cells, primarily by inhibiting ATP-consuming anabolic processes (such as protein, lipid, and ribosomal synthesis) and initiating ATP-producing catabolic pathways (such as fatty acid oxidation and glycolysis) to maintain energy homeostasis. AMPK regulates metabolic processes in various peripheral tissues, including glucose and lipid metabolism, cholesterol metabolism, and fatty acid and protein metabolism in pancreatic β-cells, the cardiovascular system, liver, kidneys, skeletal muscles, and the central nervous system. As an antidiabetic drug, the multi-organ protective effects of Glucagon-like peptide-1 receptor agonists (GLP-1RA) are increasingly being recognized. This paper reviews the mechanisms by which GLP-1RA confers organ protection via the AMPK signaling pathway.
Analytical Modelling of Fault Seal Effectiveness in Hydrocarbon Reservoirs: A Multi-Criteria Decision Analysis and Analytical Hierarchy Process Approach
Authors: Fajana Akindeji Opeyemi
Published: January 2025

Faults in hydrocarbon reservoirs significantly influence fluid flow behavior, making the prediction of fault seal effectiveness critical in reservoir management. This study introduces the FAULT-SEAL Evaluation Model (FSEM), leveraging a Multi-Criteria Decision Analysis (MCDA) and Analytical Hierarchy Process (AHP) framework. By integrating geological, geophysical, and fluid-related factors, FSEM assigns weights to key parameters, emphasizing the dominant role of clay smears and gouge composition (global weight: 0.8417) in fault-sealing potential. The Shale Gouge Ratio (SGR) and clay content emerged as the most sensitive parameters, with changes of up to 30% impacting fault seal effectiveness by as much as 0.12, underscoring their importance in fluid migration control. Fault throw and offset, with a moderate weight of 0.6262, significantly influenced the juxtaposition of rock types and sealing capacity, while stress conditions, particularly pore pressure (weight: 0.2999), moderately affected seal integrity, highlighting the need to monitor in-situ stress regimes. Validation through sensitivity analysis confirmed the model’s robustness and reliability, with a Consistency Ratio (CR) of -0.0543, ensuring minimal inconsistency in the decision matrix. These findings underscore the critical role of clay-rich fault zones in hydrocarbon trapping and the importance of detailed fault rock characterization. The FSEM offers a scalable, data-driven tool capable of generating faster, more accurate fault seal predictions, advancing exploration and production strategies. By integrating machine learning techniques and decision frameworks, the model provides an innovative approach to optimizing hydrocarbon recovery in faulted reservoirs.
A importância do diagnóstico precoce e os desafios no manejo de complicações na síndrome de Cushing endógena
Authors: Zaffari João Pedro
Published: January 2025

O presente estudo teve como objetivo verificar a importância do diagnóstico precoce e os desafios no manejo de complicações na síndrome de Cushing endógena, pois apesar da síndrome de Cushing ser uma doença rara, afeta diretamente a qualidade de vida e a mortalidade do paciente. A metodologia de pesquisa é classificada na forma de análise, com o intuito do estudo poder antecipar ou prever eventos futuros, através de bases de dados, revelando suas peculiaridades, sendo abordada de forma quantitativa, apoiando-se nos métodos de análises de dados estatísticos, de maneira concisa, e apresentando como objetivo exploratório-descritivo, visando maior um conhecimento do problema. No levantamento de dados foi revelada a média, na qual o paciente é diagnosticado após 34 meses do início da apresentação. Já um estudo realizado na Dinamarca entre os anos de 1986 a 2017, com 424 pacientes com síndrome de Cushing, sendo 225 pacientes com SC na glândula pituitária e 199 pacientes com SC adrenal constatou que a partir de 6 anos antes do diagnóstico, a taxa de emprego começa a diminuir, além disso a renda anual, o nível educacional e a capacidade de mantar relacionamentos estavam alterados antes e após o diagnóstico. Em outro levantamento a porcentagem de pacientes portadores de diabetes no momento do diagnóstico variou entre 20-47%, enquanto a pré diabetes esteve presente em 21% a 64% dos casos. No caso de doenças cardiovasculares as complicações se manifestaram na forma da hipertensão, hipocalemia, tromboembolismo, dano cardiovascular e aterosclerose. Já nos casos de distúrbios psiquiátricos existe uma alta prevalência de patologias psiquiátricas, tendo a depressão maior, transtornos como mania ou hipomania, transtornos de ansiedade, psicose, confusão, distúrbios cognitivos presentes no quadro. Além da deterioração do estado ósseo ser comum onde a osteopenia afeta de 40% a 78% deles, enquanto a osteoporose atinge de 22% a 57%, enquanto as fraturas esqueléticas são observadas em 11% a 76% dos casos.
Diretrizes Curriculares Nacionais e projeto pedagógico do curso de medicina: análise das convergências
Authors: Skzypek Jeferson Polachini , Sudbrack Edite Maria
Published: January 2025

O presente artigo tem por objetivo analisar o que dizem as Diretrizes Curriculares Nacionais para o curso de Medicina e o que apresenta o Projeto Pedagógico do Curso de Medicina de uma universidade do Rio Grande do Sul, no tangente às metodologias ativas e à avaliação por competências. Pretende-se analisar quais são as convergências entre ambos os documentos, a partir dos descritos temas. De abordagem qualitativa, a metodologia utilizada foi a leitura dos dois escritos na íntegra, selecionando os trechos que mencionavam as temáticas pretendidas, comparando-os e analisando à luz de autores como Veiga (2015), Bacich e Moran (2018) e Méndez (2011). As discussões feitas a partir desta metodologia, apontam que o PPC analisado está alinhado ao que apresentam as DCNs. Notou-se que, ao ler as ementas das disciplinas no PPC, ainda há possibilidades de ampliar a utilização das metodologias ativas e de diferentes estratégias de avaliação por competência, pois a perspectiva tradicional de educação ainda está bastante presente.
Soil management and physical attributes as a function of crops in sugarcane field renewal
Authors: Prado Eber Augusto Ferreira do , Vitorino Antonio Carlos Tadeu , Cortez Jorge Wilson , Bergamin Anderson Cristian , Koerber Maiara da Silva , Armando Egas José
Published: January 2025

The adoption of crops that precede the renewal of sugarcane fields, improves the soil physical conditions, through the addition of organic matter, the increase of biopores and greater aggregation. This work aimed to evaluate soil physical attributes after the usage of crops, in conventional tillage (CT) and in no-tillage (NT), at the time of sugarcane ​​renewal. The experimental design was a randomized block design, with five replicates. The treatments consisted in the use of Crotalaria juncea, Crotalaria ochroleuca, Helianthus annuus (sunflower), Glycine max (L.) Merrill (soybean), and Sorghum bicolor (L.) Moench, sorghum variety saccharine BRS 506, in addition to a fallow treatment. After the crop vegetative cycle of the potential sugarcane ​​renewal, soil samples were collected, with a preserved structure, using the metallic cylinder to determine soil density (SD), microporosity (Micro), macroporosity (Macro) and soil total porosity (TP) and also were collected block soil samples to determine aggregates stability, geometric mean diameter, weighted mean diameter and (ASI, GMD, WMD, and DI). C. juncea cultivation favoured the lowest values ​​of SD where CT was performed. Treatment with sunflower, soybean and sorghum favoured the lowest values ​​of SD in NT. C. juncea and soybean increased Macro and TP on CT. In NT C. juncea, sunflower and fallow increased PT. C. juncea, soybean and sorghum cultivars favoured the highest values ​​of geometric mean diameter (GMD), weighted mean diameter (WMD) and aggregate stability index (IEA). The treatment in fallow and with C. juncea favored the lowest values ​​of the dispersion index (DI). In the renewal of sugarcane cultivations with C. ochroleuca, C. juncea, sunflower, soybean and sorghum, it is not necessary to stir the soil.
THE NECESSITY FOR INVESTMENT OF ADVANCED EXPERIENCE IN THE APPLICATION OF INDIRECT TAXES IN THE REPUBLIC OF ARMENIA
Authors: Karakhanyan A.
Published: January 2025

The role of taxes is special in the financial system of every country, because they, reflecting the degree of coordination of relations between the population, economic entities and the state, are the main tool for ensuring the stability of the country and concentrating the financial resources necessary for the implementation of state functions. In turn, the tax burden, depending on the state and a number of internal functions performed there, is distributed among different types of taxes, which are classified as direct and indirect taxes.

In countries with a transition economy, such as the Republic of Armenia (RA), the main guarantors of the aforementioned stability are indirect taxes. Within the framework of the study carried out in this work, in order to understand, in general, what kind of indirect taxation systems are used in Armenia, it is necessary to analyze the relevant jurisdictions of the Tax Code of the Republic of Armenia. The development of the RA tax system is considered in the course of regular reforms in the republic, and internationally guaranteed principles are introduced in that direction. Therefore, in this work, an attempt was made to assess the possibilities of applying the advanced practice of indirect taxation in RA.
EVALUATION OF TRANSPARENCY, OPTIMIZATION OF BUDGET EXPENDITURES, AND THE STUDY OF EXISTING ISSUES IN LOCAL SELF-GOVERNMENT BODIES
Authors: Smbatyan G.
Published: January 2025

This article examines the transparency and optimization of expenditures made from the local government budgets (also referred to as LGUs) for the procurement of goods, services, and works. The study investigates the “transparency” of financial resource allocation from the LGU budgets and the procedures ensuring the transparency of spending allocated to state administrative bodies. It also presents potential solutions for addressing the issues identified in LGUs to enhance the optimization and transparency of budget spending. The study reviews several provisions of the Law on Local Self-Government of the Republic of Armenia, the Law on Procurement (including the Armenian Law on Procurement and other related legal acts), and assesses the level of residents’ awareness regarding the allocation of resources from LGU budgets.

Within the scope of this article, procurement procedures for goods, services, and works acquired through LGU budgets in Armenia from 2020 to 2024 have been analyzed, as well as existing gaps identified. By examining the electronic procurement system employed by state administrative bodies, it becomes evident that such acquisitions exhibit tendencies toward transparency and optimal expenditure of budgetary resources. However, a different situation exists in LGUs and their subordinate bodies, where transparency and trends of optimal budget spending are absent.
CHANGES IN THE SPATIOTEMPORAL DISTRIBUTION OF EARLY SPRING AND LATE AUTUMN FROSTS IN THE ARARAT BASIN
Authors: Margaryan V. , Azizyan H.
Published: January 2025

The paper analyzes and evaluates the patterns of spatiotemporal distribution of early spring and late autumn frosts observed in the air in the Ararat Basin. Frosts are dangerous agrometeorological phenomena that can partially or completely destroy agricultural crops.

Frost is a short-term decrease in temperature to 0 degrees and below in the air or on the soil surface (grass), which is observed at night (in the evening, in the morning) during the growing season against the background of positive average daily air temperatures. Moreover, during frosts in the meteorological booth (at a height of 2 m) the temperature can be slightly above 0 degrees (up to +2+3 degrees).

In the study area, late spring air frosts are observed on average from the 1st-2nd decade of April to the 1st-2nd decade of May, sometimes even in the 3rd decade of May, and early autumn frosts are observed in the 3rd decade of September-1st decade of October to the 1st decade of November.
The Impact of Consumption Downgrading on Housing Purchase Decision of Chinese Middle Class: An Analysis Based on the Life Cycle Theory and Marriage Market Theory
Authors: Li Ziming
Published: January 2025

In the face of the trend of consumption downgrading, the purchasing decisions of the middle class regarding real estate have undergone new changes. Existing literature on the housing market and purchasing behavior of the middle class under the trend of consumption downgrading suggests that the purchasing power of the middle class has generally decreased, with many unable to bear the costs of mortgage loans and other housing-related financial burdens. As a result, the number of people purchasing real estate in the future may decrease. Based on existing research and practical needs, this paper summarizes the trends of previous studies through a literature review, pointing out their shortcomings. The paper further explores the decision-making process of the middle class in the context of consumption downgrading and analyzes the reasons for this situation using the Life Cycle Theory and Marriage Market Theory. The goal of this research is to provide policy recommendations for policymakers and reasonable suggestions for middle-class housing consumption decisions. The analysis shows that the middle class tends to rent housing or purchase small-sized properties, and that owning property is an important factor in the marriage market, especially from adulthood to the marriage stage.
In-depth Analysis and Prospect of Factors Influencing Corporate ESG Performance
Authors: Wang Xichen
Published: January 2025

The ESG (Environmental, Social, and Governance) concept is receiving increasing attention globally and has become an important consideration factor for corporate sustainable development. This article provides an in-depth analysis of the factors influencing corporate ESG performance. Firstly, the research background was elaborated, including the attention of governments, investors, and society to corporate ESG performance in the context of global sustainable development trends. The research objective is to provide theoretical support and practical guidance for enterprises to improve their ESG level, and to provide decision-making basis for investors. Through literature review, the current research status and shortcomings at home and abroad are sorted out, and literature research and case analysis methods are used for research. Analyzed the relevant applications of ESG ratings, including becoming a decision-making basis for investors globally, being used by companies for governance and performance improvement, and the influence and application scope in the financial industry. Explored the internal and external factors influencing corporate ESG performance, and provided recommendations for companies, investors, and regulatory agencies. Finally, an outlook on the future ESG performance of enterprises was provided. This study indicates that corporate ESG performance is influenced by multiple factors such as environment, society, governance, and supply chain finance. Improving corporate ESG performance requires joint efforts from businesses, governments, investors, and all sectors of society. In the future, ESG research should be further strengthened to promote sustainable development of enterprises.
The Impact of Digital Inclusive Finance on Regional Economic Growth and Environmental Quality
Authors: Wang Yue
Published: January 2025

China has prioritized high-quality development as a key goal in building a socialist modernized country. Currently, regional economic development faces challenges such as blocked factor flows, regional disparities, and environmental degradation, highlighting the need for coordinated economic and environmental progress. This paper explores how digital inclusive finance impacts regional economic development and environmental quality. Using panel data from 31 provinces (20122022) and a bidirectional fixed-effect regression model, the study finds that digital inclusive finance drives economic growth through technological innovation and enhances environmental quality via industrial upgrading. This research offers empirical evidence on the role of digital finance in regional development and provides policy insights for promoting green transformation and sustainable growth.
The Role of Fabric Modification in Enhancing Brand Recognition in Fashion
Authors: Dai Yuxuan
Published: January 2025

In the highly competitive fashion industry, fabric modification has become one of the most important strategies for brand differentiation and increasing brand recognition. This study will look into how fabric modification techniques, such as advanced dyeing, texturing, and the use of sustainable materials, can be used to build a distinct brand identity that contributes to improved consumer memory and loyalty. The focus of the study is based on how fabric innovations could give consumers better visual and tactile experiences besides strengthening their ties to whatever brand. To explore the relationships above, the study adopts a qualitative approach by conducting in-depth research in leading fashion brands, such as Burberry, Nike, and Stella McCartney, accompanied by interviews that have been conducted with experts in textile production and marketing. The case studies delineate the different ways through which fabric manipulations relate to consumer perception and loyalty through practical, aesthetic, and functional effects. The findings indicate that fabric innovations do not only increase the aesthetic appeal in fashion products but also play a substantial role in the formation of consumer perception through the creation of emotional links and sensory engagement. Practices in sustainable fabric modification, such as using recycled or biodegradable materials, give a competitive advantage by appealing to environmentally conscious consumers. This research will highlight how fabric innovation can provide an important source of competitive differentiation and congruence with consumer values, rendering actionable insight for designers and marketers in a dynamic marketplace.
Spiritual Intelligence of Students Entering Undergraduate medical course in an Indian Medical College
Authors: Vaishnav Bhalendu , Verma Jagdish , Prabhakaran Anusha , Ganjiwale Jaishree , Vaghela Nirav , Vaishnav Rutam , Vaishnav Smruti
Published: January 2025

Background: Spiritual intelligence [SI] is reported to provide meaning-giving and context-creator functionality, besides enhancing academic engagement and care competence. Enabling medical students to become aware about their own SI has a potential to provide a transformational edge to the learning process. Method: We studied spiritual intelligence, daily spiritual practices, and work satisfaction of 127 students of first year undergraduate course in an Indian medical college using a questionnaire-based survey. Spiritual Intelligence Self-Report Inventory [SISRI 24] was used which measures overall spiritual intelligence and its 4 components: Critical existential thinking, Personal meaning production, Transcendental awareness, Conscious state expansion. Results were analysed by STATA 14 software. Results: Eighty five percent students had moderate/high SI. Scores: Critical existential thinking [17.0/28], Personal meaning production [12.9 /20],Transcendental awareness [17.8/28], Conscious state expansion [9.8./20] . SI was significantly associated with work satisfaction[p=0.006]. More than 80% students were regularly undertaking spiritual practices [prayer, meditation, etc]. Students consider spirituality as an important is helpful in professional growth. Conclusion: First year medical students have moderate/high spiritual intelligence associated with good work satisfaction. Students consider spirituality as essential component of education for enhancing self-development and professional competence. Students entering medical studies should be provided opportunities for exploring their spiritual insight and strengthening the same for as a pedagogic intervention.
Effect of yoga in diabetic patients with hypertension: An observational study
Authors: Dash Satarupa , Thakur Atanu , Nanda Rajiv
Published: January 2025

Background:
The most common chronic non - communicable diseases in the world is Diabetes mellitus. The incidence of diabetes mellitus is increasing with the increase in physical inactivity, sedentary lifestyle and unhealthy dietary habits. In addition to increased glucose level plasma lipid parameters also increase in NIDDM patients. Hypertension is one of the common complications of diabetes which further aggravates the problem. Yoga is an ancient Indian science. Now a days yoga has been applied in the field of therapeutics in various diseases like diabetes, asthma, hypertension.

Aim:
The objective of this case study is to understand effect of yoga in type 2 diabetics with hypertension.

Methods:
The study is conducted on outdoor patient basis at Dept. of medicine VIMSAR Burla with the help of department of Physiology and yoga center Sambalpur. Forty patients with Type 2 Diabetes Mellitus (NIDDM) and hypertensive were put through various Yogic asana for 90 days, together with diet plus diabetic medicines. The basal parameters studied include the biochemical investigations like FBG, PPBG, HbA1C and lipid profile along with SBP, DBP.

Results:
Systolic and diastolic blood pressure, fasting, post-prandial blood glucose level and LDL, VLDL, TG, TC showed significant reduction (p value <0.05) with no change in HDL and HbA1C level in tpe 2 diabetic patients with hypertension.

Conclusions:
It may be concluded that yoga helps in decreasing blood sugar level and keep the diabetes in control. The change in lipid profile status prevents the early development of comorbid condition like hypertension, coronary artery disease. It can be concluded that yoga asana and pranayama may be used as an adjunct to medical therapy to emphasizes the control and to manage type 2 diabetes mellitus with hypertension.
Correlation between personality type & Cognitive evoked potential: A comprehensive study
Authors: Arumugam Parthiban , Karunamoorthy Vanathy , Tharanitharan Thirumeni
Published: January 2025

Background:
Among the five distinct categories of personality domain, the Extraversion-Introversion continuum is the most stable personality trait across a person's lifespan.
In his theory, Eysenck notes that one's level of cortical arousal explains their degree of extraversion. In research related to personality dimension, the P300 Event Related Potential component is most notably investigated in relation to extraversion. It is the cognitive evoked potential appearing at about 300 millisecond following task related stimuli.
Objective:
To compare and correlate P 300 amplitude & latency of cognitive evoked potential response among extraverts & introverts
Methodology:
The Universiti Sains Malaysia Personality Inventory (USMaP-i) was used to assess the personality of the participants in the age group of 18-35 years of either gender and they were categorized into specific personality trait- Extravert & Introvert. The participants were assessed for hearing deficit with tuning fork tests (Rinne‘s, Weber‘s & Schwabach‘s test). The recruited participants underwent recording of cognitive event related evoked potential in the research laboratory. P 300 amplitude & latency were analyzed via evoked potential recorder, Medicaid Neurostim apparatus.

Result:
The current study revealed that there exists significant differences in P 300 amplitude & latency among extraverts & introverts
Conclusion:
There exists inherent differences in the personality among the people living in our society and once we tend to acknowledge the same, we can live in a more harmonious relationship with each other.
IMPACT OF STRESS ON BLOOD PRESSURE AND LIPID PROFILE OF FIRST YEAR MBBS STUDENTS - A CROSS-SECTIONAL STUDY
Authors: ROY DR , GUHA DR , BANERJEE DR , CHAKRAVARTY DR
Published: January 2025

ABSTRACT PAGE
Background – Increased incidences of psychological disorders have become an important health problem in the world. Stress may impair cognitive functioning and learning of a student. In future life it may lead one to burnout and suicidal ideation. It also has an impact on various aspects of physical health. It is undeniable that life of a medical student studying MBBS is stressful hence proper stress ameliorative measures may be implemented to produce stress free holistic confident practitioners.
Aim – To study the impact of stress with blood pressure and Lipid profile of first year medical students. Methods and Material – The study was single point cross sectional, conducted on first year MBBS student after taking approval of institutional ethical committee. Eighty-four students were selected based on inclusion and exclusion criteria after taking due consent. Stress levels were assessed using DASS questionnaire. Lipid profile of selected students was done and blood pressure measurements were taken with mercury sphygmomanometer. Results – The findings of the various parameters were statistically analysed according to percentage, Chi- square test and p-value. In this study a statistically significant (As P value < 0.05) association was found in case of students who were moderate to severely stressed to their corresponding diastolic and systolic blood pressure values. However no significant association was found between the stress level and their corresponding serum LDL values.
Conclusion – The study concludes that stress amongst first year MBBS students is highly significant which not only affects their academic achievements but also other aspects of health like hypertension and dyslipidaemia.
A STUDY TO FIND OUT ASSOCIATION BETWEEN FITNESS INDEX OF AN INDIVIDUAL WITH BLOOD GROUP GENOTYPE
Authors: Dubal Gitesh , Vala Nileshwari
Published: January 2025

Background: The Fitness Index, a measure of cardiac and muscular system strength, may vary among individuals with different blood groups due to genetic or immunological factors influencing disease susceptibility and overall health, prompting this study to investigate these potential correlations. Aim: To find out any association between ABO & Rh blood groups and fitness index of healthy individuals. Methods: The study involved healthy individuals over 18 years old without known cardiac conditions, who underwent a two-step exercise on a wooden staircase at a rate of 30 steps per minute for five minutes. The recovery pulse rate was measured at intervals after the exercise, and this data was used to calculate the Fitness Index using the formula. The Fitness Index was then categorized as "poor" if less than 50, "average" if between 50 and 80, and "good" if more than 80. The study included 165 cases over a span of six months, and the data was analyzed using single way ANOVA. Results: The study of 165 participants found no significant association between Fitness Index and blood group (p=0.493). Highest Fitness Index was found in the AB+ blood group with a mean of 71.29. However, a significant association was found between Fitness Index and gender, with females showing a higher Fitness Index than males (p=0.018). Conclusion: The study concluded that while the highest Fitness Index was found in the AB+ blood group, the O+ blood group showed better reliability and accuracy for association with the Fitness Index due to a larger sample size. However, no significant association was found between an individual's blood group and Fitness Index (p=0.493). A strong association was found between gender and Fitness Index (p=0.018), with females showing a higher Fitness Index than males, possibly due to better BMI, physical activity, diet, and lifestyle. Further studies are needed to confirm this association.
TITLE:
Determination of Clinical and Radiological severity of COVID- 19 infection among vaccinated and non-vaccinated patients: A retrospective study in a tertiary care hospital

Authors:
1.Dr Indushree T,
2. Dr.Malini.S,
3. Dr. Prashanth D
4. Dr.Siddeshwarswamy P
5. Dr. Lakshmi D
Authors: T Indushree , S Malini , D Prashanth , P Siddeswaraswamy , D Lakshmi
Published: January 2025

Background: The COVID-19 pandemic has spurred global efforts for vaccination. Understanding the severity of infection among vaccinated and non-vaccinated individuals can inform clinical practice and public health measures. Objective: To compare the clinical and radiological severity of COVID-19 infections between vaccinated and non-vaccinated patients in a tertiary care hospital setting. Methods: A retrospective review of patient records from January to December 2022 at Sri Siddhartha Medical College and research centre, tertiary care centre. Clinical severity was categorized as mild, moderate, or severe based on WHO guidelines. Radiological severity was evaluated based on standard CT severity scores. Comparisons were made between the two groups, adjusting for confounding variables like age, gender, and comorbidities. Results: In a study of 150 individuals, 100 had received the vaccine while 50 had not. Those who were vaccinated displayed markedly fewer severe clinical symptoms (p < 0.001) and demonstrated decreased CT severity scores (p < 0.005) when compared to the non-vaccinated group. Though age and pre-existing health conditions played a role in the severity of symptoms, the vaccine's protective benefits were still pronounced after accounting for these factors. Conclusion: Vaccination against COVID-19 significantly reduces the clinical and radiological severity of the disease in patients. This study underscores the importance of widespread vaccination to mitigate the impact of the virus on individual health and hospital resources.
Correlation of sleep deprivation and lipid profile among healthy volunteers – A crosssectional study
Authors: Mathialagan Renu , K Deepalakshmi
Published: January 2025

Background: Sleep deprivation acts as a potential risk factor for causing metabolic imbalance in our body. It increases cortisol level and contributes to insulin resistance and dyslipidemia. Hence it is necessary to identify the importance of adequacy of sleep in optimizing lipid metabolism.

Objective: To find out the impact of sleep deprivation on the lipid profile among healthy volunteers

Methods: Participants sleep quality was assessed by administering the Pittsburgh Sleep Quality Index (PSQI) questionnaire. The lipid profile parameters like Total Cholesterol (TC), Triglycerides (TG), High Density Lipoprotein (HDL), Low-Density Lipoprotein (LDL) and Very Low-Density Lipoprotein (VLDL) were obtained from their clinical records. Based on PSQI scores study population was divided into Group A (Score < 5) and Group B (Score ≥5).The statistical analysis was performed by using students paired t test. Correlations of lipid profile with their quality of sleep were performed using Pearson’s correlation.

Results: The PSQI values were also found to be increased in group B compared to group A. When compared with group A, group B showed increased TG, LDL and VLDL levels with a p value of 0.0017,0.000,0.0517 respectively.TC (0.832) and LDL (0.9144) showed positive statistical correlation with high PSQI score. HDL(-0.5542) showed negative correlation with high PSQI score. TG and VLDL showed weak positive correlation.
Conclusion: In our study the participants with high PSQI score had more sleep disturbance and abnormal lipid profile when compared to participants with normal PSQI score. So, quality of sleep plays an integral role in preventing dyslipidemia and cardiovascular disorders
The Association Between Obesity and Cognitive Function in Middle-Aged Adults: A Cross-Sectional Study in South India
Authors: A Divya , Johnson Priscilla , K Maheshkumar
Published: January 2025

Introduction: Obesity has emerged as a critical public health issue in India, with a notable rise in prevalence, particularly among women. The relationship between obesity and cognitive function remains underexplored, especially in non-Western populations. This study aims to investigate the association between obesity and cognitive function in middle-aged women in Chennai, South India.
Methods:A cross-sectional study was conducted among 140 healthy female subjects aged 40-60 years, categorized into four groups based on BMI: Normal (18.5-22.9 kg/m²), At Risk (23-24.9 kg/m²), Obese 1 (25.0-29.9 kg/m²), and Obese 2 (>30 kg/m²). Anthropometric measurements were taken, and cognitive function was assessed using the Addenbrooke’s Cognitive Examination (ACE) questionnaire, covering domains such as attention/orientation, memory, verbal fluency, language, and visuo-spatial abilities. Data analysis was performed using R statistical software, with ANOVA and post hoc tests to compare groups, and Pearson correlation to examine associations between anthropometric values and cognitive scores.
Results:Significant differences were found in height, weight, BMI, waist circumference, hip circumference, and neck circumference across BMI groups (p < 0.001). Cognitive scores significantly decreased with increasing BMI across all domains (p = 0.0001). Orientation/Attention, Memory, Verbal Fluency, Language, and Visuo-Spatial Ability scores were lowest in the Obese 2 group. Strong negative correlations were observed between BMI (r = -0.84, p = 0.0001), waist circumference (r = -0.49, p = 0.0001), hip circumference (r = -0.54, p = 0.0001), neck circumference (r = -0.41, p = 0.0001), and cognitive scores. The waist-hip ratio did not show a significant correlation with cognitive scores.
Conclusion:This study demonstrates a significant association between obesity and cognitive impairment in middle-aged women. Reducing excess weight through interventions such as diet and physical activity may improve cognitive function and reduce morbidity and mortality. Early intervention is crucial for optimal benefits
A Population-Based Study of Diabetes Mellitus and Association with Human ABO Blood Groups
Authors: Mahjour Marjan , Jarahi Lida , Doustparast Armin , Boskabadi Amin , Kaheni Amir , Hadirudi Hamid
Published: January 2025

ABSTRACT
Background: With the increasing importance of personalized patient management, effective analysis of various patient data can play an important role in identifying people at risk of high-burden diseases like diabetes mellitus(DM). By studying the correlation between DM and blood groups, potential risk factors can be identified, leading to personalized strategies for screening and prevention.
Objectives: This study aims to investigate the association between type 2 DM (T2DM) and different blood groups.
Materials and Methods: Date was extracted from a population database of Mashhad Health Care Centers, the second metropolitan city in Iran. From 169,536 individuals who were referred for DM management, data of 6801 persons was extracted. The control group consisted of non-diabetic individuals, who were matched in terms of sex and age. Demographic variables, medical history, and blood groups were obtained.
Results: The mean(SD) age of diabetic individuals was 41.3(8.6) years, 80% being overweight or obese. Among T2DM patients, blood type O was the most common, followed by A, and blood type AB had the lowest prevalence (32.7%, 30.6%, and 9.3% respectively). Compared to the control group, Blood type O showed a higher prevalence in DM (P-value=0.001). Diabetic persons with blood type O had a higher occurrence of T2DM in their family history (P-value=0.01).
Conclusion: In patients with T2DM, the most frequent blood type was O, with A coming in second. It seems that those with O+ blood type are more susceptible to developing T2DM. Additionally, differences and inconsistencies have been noted among various countries, hinting at the possible impact of other factors.
Correlation of glycated haemoglobin( HbA1c) with TNF-α and Oxidised-LDL in Type 2 DM.
Authors: Pawar Pratibha , Dhama Anjali , Chahal Aakriti , Ghalaut Veena
Published: January 2025

Background: Type 2 DM (Diabetes Mellitus) is rising as a major health concern worldwide. The pathogenesis of DM and its complications involve an array of dynamic interactions between genes, inflammatory cytokines like (TNF-α), oxidative stress, environmental factors and lifestyle. Several studies have shown a strong correlation of Ox-LDL (Oxidisedd low-density lipoprotein) and TNF-α (Tumor necrosis factor-α) with IR (Insulin resistance). Hence, the present study was designed to study the correlation between HbA1c (Glycated haemoglobin) (a marker of glycemic control) with TNF-α (a marker of chronic inflammation) and Ox-LDL (a marker of oxidative stress).
Aim & Objectives: To study the correlation between TNF-α and Ox-LDL with HbA1c in Type 2 DM.
Methods: For our pilot study, we recruited patients with type 2 DM belonging to age group 35-50 years of either gender from Medicine OPD as cases. The institutional ethics committee approval has been taken before commencement of the study. After informed consent from patients, venous blood samples were collected and analysed using Biochemistry autoanalyser and appropriate ELISA kit. Data was analysed statistically using SPSS software.
Result: The study showed raised levels of HbA1c, TNF-α and OX-LDL in type 2 DM patients.
Conclusion: Furthermore, a significant positive correlation was observed between TNF-α and HbA1c (r = 0.829) and also between Ox-LDL and HbA1c (r = 0.638).
Evaluation of pattern of drug use among Acne vulgaris patients in a Tertiary care teaching hospital.
Authors: thangarasu nageswari , adhimoolam mangaiarkkarasi
Published: January 2025

ABSTRACT
Background: Acne Vulgaris is the common skin lesion observed in the clinical practice. This study was planned to evaluate the drug prescription pattern among Acne vulgaris patients in a Tertiary care teaching hospital.
Objectives: To study the pattern of drug use among Acne vulgaris patients in a Tertiary care teaching hospital using WHO core prescribing Indicators.
Materials and methods: This hospital based Cross-Sectional observational study was conducted among 100 Acne vulgaris patients from Department of Dermatology & Venerology and Department of Pharmacology for 6 months (November 2022 to March 2023). Prescriptions were analyzed using WHO core prescribing indicators. Microsoft Excel 21 was used to analyze the data and expressed in Percentage.
Results: As per WHO core drug prescribing indicators, the average number of drugs per encounter was 2.12. The drugs prescribed by generic name was 58.49%. The percentage of encounters with antibiotics was 72%. The percentage of encounters with injection was nil. The drugs prescribed by generic name was 12.73%
Conclusion: The study showed that the most common clinical presentation of acne was papules (34%), pustules (24%) over cheeks. 20.8% of patients received topical antibiotics, 19.3% oral antibiotics, 8.4% topical retinoids, 2.3% oral retinoids and 25% received skin care products. 58.4% of drugs were prescribed by generic name and 12.7% only were prescribed from WHO essential drug list as per the drug prescribing indicators.