bluuebunny/crossref_metadata_2025 huggingface dataset:
Narrowing Linewidth of Wavelength-Swept Active Mode Locking Laser Based on Cross Gain Modulation
Authors: Park Se Jin , Kim Gyeong Hun , Lee Hwi Don , Kim Chang-Seok , Jo Minsik
Published: September 2019

We demonstrate a novel narrow-linewidth configuration of a wavelength-swept active mode locking (AML) fiber laser. The frequency response of the modulation depth of a semiconductor optical amplifier can be improved in a higher modulation frequency region by adapting the cross gain modulation (XGM) configuration, compared to that of the conventional direct gain modulation (DGM) configuration. As a sufficient modulation depth is implemented for an AML at higher modulation frequencies at around gigahertz order, it results in a narrower linewidth of lasing output. For the same modulation frequency of 1361.25 MHz, the linewidth of 0.25 nm with DGM becomes narrower up to 0.113 nm with XGM, which corresponds to an improved point spread function with 1.41 mm of 6-dB roll-off.
Research on Low Energy Consumption Static Postures of Bionic Feet
Authors: Zhang Lei , Gao Shuangshuang , Ma Shugen , Gao Zenghui , Li Ang
Published: September 2019

By studying the relation of the robot’s postures and its energy consumption, a static analysis-based method to obtain the low-energy postures of the robot is proposed. This method decreases the energy consumption and increases the battery life by adjusting the postures in the horizontal environment. The method takes the low-speed hexapod bionic robot as the research object. First, we obtain the output torque of each joint of the leg through static analysis and establish the energy consumption model of the robot. Considering the flexibility of the robot, we then introduce the performance index of the maximum step length and establish an equilibrium solution based on energy consumption and maximum step size. Finally, we derive the low-energy postures of the robot using MATLAB (MATLAB 2014a, The MathWorks, Natick, Massachusetts State, USA, 2014) simulations. An energy consumption experiment is carried out with a physical prototype to verify the validity of the method.
Advances in Computational Fluid Mechanics in Cellular Flow Manipulation: A Review
Authors: Arabghahestani Masoud , Poozesh Sadegh , Akafuah Nelson K.
Published: September 2019

Recently, remarkable developments have taken place, leading to significant improvements in microfluidic methods to capture subtle biological effects down to single cells. As microfluidic devices are getting sophisticated, design optimization through experimentations is becoming more challenging. As a result, numerical simulations have contributed to this trend by offering a better understanding of cellular microenvironments hydrodynamics and optimizing the functionality of the current/emerging designs. The need for new marketable designs with advantageous hydrodynamics invokes easier access to efficient as well as time-conservative numerical simulations to provide screening over cellular microenvironments, and to emulate physiological conditions with high accuracy. Therefore, an excerpt overview on how each numerical methodology and associated handling software works, and how they differ in handling underlying hydrodynamic of lab-on-chip microfluidic is crucial. These numerical means rely on molecular and continuum levels of numerical simulations. The current review aims to serve as a guideline for researchers in this area by presenting a comprehensive characterization of various relevant simulation techniques.
Human Neural Stem Cells Flown into Space Proliferate and Generate Young Neurons
Authors: Cepeda Carlos , Vergnes Laurent , Carpo Nicholas , Schibler Matthew J. , Bentolila Laurent A. , Karouia Fathi , Espinosa-Jeffrey Araceli
Published: September 2019

Here we demonstrate that human neural stem cells (NSCs) proliferate while in space and they express specific NSC markers after being in space. NSCs displayed both higher oxygen consumption and glycolysis than ground controls. These cells also kept their ability to become young neurons. Electrophysiological recordings of space NSC-derived neurons showed immature cell membrane properties characterized by small capacitance and very high input resistance. Current injections elicited only an incipient action potential. No spontaneous synaptic events could be detected, suggesting their immature status even though most recorded cells displayed complex morphology and numerous cell processes. Ascertaining the origin of the NSCs’ increased energy requirement is of the essence in order to design effective measures to minimize health risks associated with long-duration human spaceflight missions.
In-Situ Continuous Monitoring of the Viscosity of Surfactant-Stabilized and Nanoparticles-Stabilized Pickering Emulsions
Authors: Bains Upinder , Pal Rajinder
Published: September 2019

An in-situ method of measuring the viscosity of unstable and stable emulsions on a continuous basis under agitation conditions was developed and utilized to investigate the viscous behaviour of surfactant-stabilized and nanoparticles-stabilized oil-in-water (O/W) emulsions at different volume fractions of the dispersed phase (oil). The stability characteristics (droplet size and phase-separation) of emulsions under quiescent conditions were also determined with the aging of emulsions. Emulsions are Newtonian at low volume fractions of the dispersed phase. At high concentrations of the dispersed phase, emulsions behave as non-Newtonian shear-thinning fluids. The nanoparticles-stabilized (Pickering) emulsions are unstable in comparison with the surfactant-stabilized emulsions. The droplet sizes of Pickering emulsions increase rapidly with aging, whereas the droplet sizes of surfactant-stabilized remain nearly the same over a period of 24 h. However, Pickering emulsions are much more viscous than the surfactant-stabilized emulsions when comparison is made at the same volume fraction of the dispersed phase.
The Impact-Tensile Behavior of Cementitious Composites Reinforced with Carbon Textile and Short Polymer Fibers
Authors: Gong Ting , Heravi Ali. A. , Alsous Ghaith , Curosu Iurie , Mechtcherine Viktor
Published: September 2019

The paper at hand focuses on the tensile behavior of ductile cementitious composites reinforced with short, randomly distributed, polymer fibers and a continuous carbon textile under quasi-static and impact loading. Strain-hardening cement-based composites (SHCCs) made of high strength fine-grained matrix with the addition of a 2% volume fraction of 6 mm-long ultra-high molecular weight polyethylene (UHMWPE) fibers and as-spun poly(p-phenylene-2,6-benzobisoxazole) (PBO-AS) fibers, respectively, were reinforced with one layer of carbon textile, which corresponds to a 0.68% volume fraction. The same fine-grained matrix reinforced with carbon textile only served as the reference material. The synergetic action of the two reinforcement types was investigated in uniaxial tension tests on composite specimens, as well as by means of single-yarn pullout tests at displacement rates of 0.05 mm/s in a hydraulic testing machine, and 8 m/s in a tensile split Hopkinson bar. The specimen’s deformations, the formation of cracks, and the fracture processes were monitored optically and subsequently evaluated using digital image correlation (DIC).
Control Technology of Ground-Based Laser Communication Servo Turntable via a Novel Digital Sliding Mode Controller
Authors: Zhang Jianqiang , Liu Yongkai , Gao Shijie , Han Chengshan
Published: September 2019

In this study, a sliding mode control (SMC) algorithm was proposed based on a novel reaching law to solve the nonlinear disturbance problem of a ground-based laser communication turntable. This algorithm is a chatter-free method, in which the coefficient of sliding mode variable structure function is designed as an adaptive function, so the chattering of the sliding mode approaches zero. For any perturbed system, this algorithm can ensure a finite time for the system state to reach the sliding mode surface from any initial state. Additionally, the system will stabilize in the quasi-sliding mode domain (QSMD) with O(T3) width, where a narrower QSMD width corresponds to stronger robustness toward nonlinear disturbances. Both mathematical calculations and simulations verified the sliding mode and stability of this control algorithm. Experimental results of the velocity closed-loop of pitch axis show that the proposed algorithm effectively improved the anti-nonlinear disturbance ability of the control system compared with the effects of the traditional digital PID and the existing chatter-reduced SMC algorithms, for smooth system operation.
Prediction of Concrete Strength with P-, S-, R-Wave Velocities by Support Vector Machine (SVM) and Artificial Neural Network (ANN)
Authors: Park Jong Yil , Yoon Young Geun , Oh Tae Keun
Published: September 2019

Mechanical waves, such as ultrasonic waves, have shown promise for use in non-destructive methods used in the evaluation of concrete properties, such as strength and elasticity. However, accurate estimation of the concrete compressive strength is difficult if only the pressure waves (P-waves) are considered, which is common in non-destructive methods. P-waves cannot reflect various factors such as the types of aggregates and cement, the fine aggregate modulus, and the interfacial transition zone, influencing the concrete strength. In this study, shear waves (S-waves) and Rayleigh waves (R-waves) were additionally used to obtain a more accurate prediction of the concrete strength. The velocities of three types of mechanical waves were measured by recent ultrasonic testing methods. Two machine learning models—a support vector machine (SVM) and an artificial neural network (ANN)—were developed within the MATLAB programming environment. Both models were successfully used to model the relationship between the mechanical wave velocities and the concrete compressive strength. The machine learning model that included the P-, S-, and R-wave velocities was more accurate than the model that included only the P-wave velocity.
The Baja California Peninsula, a Significant Source of Dust in Northwest Mexico
Authors: Morales-Acuña Enrique , Torres Carlos , Delgadillo-Hinojosa Francisco , Linero-Cueto Jean , Santamaría-del-Ángel Eduardo , Castro Rubén
Published: September 2019

Despite their impacts on ecosystems, climate, and human health, atmospheric emissions of mineral dust from deserts have been scarcely studied. This work estimated dust emission flux (E) between 1979 and 2014 from two desert regions in the Baja California Peninsula (BCP) using a modified dust parameterization scheme. Subsequently, we evaluated the processes controlling the variability of E at intra- and interannual scales. During the period 1979–2014 peak E were generally recorded in summer (San Felipe) and spring (Vizcaino), and the lowest emissions occurred in autumn (San Felipe) and winter (Vizcaíno). Intra- and interannual variability in E was associated with fluctuations in wind speed and direction, precipitation, and soil moisture, which, in turn, were controlled by the seasonal displacement of the North Pacific high-pressure center. Key drivers of the interannual variability of E are strong El Niño Southern Oscillation (ENSO) events. These climatic events and the hydrometeorological variables mentioned above played a major role in the onset and occurrence of dust events, with the highest annual emissions at Vizcaíno. Besides, a lag of 19 months (San Felipe) and 21 months (Vizcaino) was recorded between the occurrence of relevant E and ENSO events, apparently in response to the effect of this climatic event on precipitation. The climate variability of E in both desert regions was evidenced by the positive trends associated with increases in wind speed and air temperature, and with decreases in precipitation and soil moisture. Finally, our findings suggest that the BCP should be considered as a significant source of dust for the regional inventory of particulate matter emissions from the Earth’s surface.
A Spatial and Temporal Risk Assessment of the Impacts of El Niño on the Tropical Forest Carbon Cycle: Theoretical Framework, Scenarios, and Implications
Authors: Esquivel-Muelbert Adriane , Bennett Amy C. , Sullivan Martin J. P. , Baker Jessica C. A. , Gavish Yoni , Johnson Michelle O. , Wang Yunxia , Chambers-Ostler Alexander , Lisli Giannichi Marta , Gomes Luciene , Kalamandeen Michelle , Charan Pattnayak Kanhu , Fauset Sophie
Published: September 2019

Strong El Niño events alter tropical climates and may lead to a negative carbon balance in tropical forests and consequently a disruption to the global carbon cycle. The complexity of tropical forests and the lack of data from these regions hamper the assessment of the spatial distribution of El Niño impacts on these ecosystems. Typically, maps of climate anomaly are used to detect areas of greater risk, ignoring baseline climate conditions and forest cover. Here, we integrated climate anomalies from the 1982–1983, 1997–1998, and 2015–2016 El Niño events with baseline climate and forest edge extent, using a risk assessment approach to hypothetically assess the spatial and temporal distributions of El Niño risk over tropical forests under several risk scenarios. The drivers of risk varied temporally and spatially. Overall, the relative risk of El Niño has been increasing driven mainly by intensified forest fragmentation that has led to a greater chance of fire ignition and increased mean annual air temperatures. We identified areas of repeated high risk, where conservation efforts and fire control measures should be focused to avoid future forest degradation and negative impacts on the carbon cycle.
Kinetic Transition in Amyloid Assembly as a Screening Assay for Oligomer-Selective Dyes
Authors: Barton Jeremy , Arias D. Sebastian , Niyangoda Chamani , Borjas Gustavo , Le Nathan , Mohamed Saefallah , Muschol Martin
Published: September 2019

Assembly of amyloid fibrils and small globular oligomers is associated with a significant number of human disorders that include Alzheimer’s disease, senile systemic amyloidosis, and type II diabetes. Recent findings implicate small amyloid oligomers as the dominant aggregate species mediating the toxic effects in these disorders. However, validation of this hypothesis has been hampered by the dearth of experimental techniques to detect, quantify, and discriminate oligomeric intermediates from late-stage fibrils, in vitro and in vivo. We have shown that the onset of significant oligomer formation is associated with a transition in thioflavin T kinetics from sigmoidal to biphasic kinetics. Here we showed that this transition can be exploited for screening fluorophores for preferential responses to oligomer over fibril formation. This assay identified crystal violet as a strongly selective oligomer-indicator dye for lysozyme. Simultaneous recordings of amyloid kinetics with thioflavin T and crystal violet enabled us to separate the combined signals into their underlying oligomeric and fibrillar components. We provided further evidence that this screening assay could be extended to amyloid-β peptides under physiological conditions. Identification of oligomer-selective dyes not only holds the promise of biomedical applications but provides new approaches for unraveling the mechanisms underlying oligomer versus fibril formation in amyloid assembly.
Exploring the Interactions of Ruthenium (II) Carbosilane Metallodendrimers and Precursors with Model Cell Membranes through a Dual Spin-Label Spin-Probe Technique Using EPR
Authors: Carloni Riccardo , Sanz del Olmo Natalia , Ortega Paula , Fattori Alberto , Gómez Rafael , Ottaviani Maria Francesca , García-Gallego Sandra , Cangiotti Michela , de la Mata F. Javier
Published: September 2019

Dendrimers exhibit unique interactions with cell membranes, arising from their nanometric size and high surface area. To a great extent, these interactions define their biological activity and can be reported in situ by spin-labelling techniques. Schiff-base carbosilane ruthenium (II) metallodendrimers are promising antitumor agents with a mechanism of action yet to explore. In order to study their in situ interactions with model cell membranes occurring at a molecular level, namely cetyltrimethylammonium bromide micelles (CTAB) and lecithin liposomes (LEC), electron paramagnetic resonance (EPR) was selected. Both a spin probe, 4-(N,N-dimethyl-N-dodecyl)ammonium-2,2,6,6-tetramethylpiperidine-1-oxyl bromide (CAT12), able to enter the model membranes, and a spin label, 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) covalently attached at newly synthesized heterofunctional dendrimers, were used to provide complementary information on the dendrimer–membrane interactions. The computer-aided EPR analysis demonstrated a good agreement between the results obtained for the spin probe and spin label experiments. Both points of view suggested the partial insertion of the dendrimer surface groups into the surfactant aggregates, mainly CTAB micelles, and the occurrence of both polar and hydrophobic interactions, while dendrimer–LEC interactions involved more polar interactions between surface groups. We found out that subtle changes in the dendrimer structure greatly modified their interacting abilities and, subsequently, their anticancer activity.
High Energy Intake Induced Overexpression of Transcription Factors and Its Regulatory Genes Involved in Acceleration of Hepatic Lipogenesis: A Rat Model for Type 2 Diabetes
Authors: Khadke Suresh P. , Kuvalekar Aniket A. , Harsulkar Abhay M. , Mantri Nitin
Published: September 2019

Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by impaired insulin action and its secretion. The objectives of the present study were to establish an economical and efficient animal model, mimicking pathophysiology of human T2DM to understand probable molecular mechanisms in context with lipid metabolism. In the present study, male Wistar rats were randomly divided into three groups. Animals were fed with high fat diet (HFD) except healthy control (HC) for 12 weeks. After eight weeks, intra peritoneal glucose tolerance test was performed. After confirmation of glucose intolerance, diabetic control (DC) group was injected with streptozotocin (STZ) (35 mg/kg b.w., i.p.). HFD fed rats showed increase (p ≤ 0.001) in glucose tolerance and HOMA-IR as compared to HC. Diabetes rats showed abnormal (p ≤ 0.001) lipid profile as compared to HC. The hepatocyte expression of transcription factors SREBP-1c and NFκβ, and their target genes were found to be upregulated, while PPAR-γ, CPT1A and FABP expressions were downregulated as compared to the HC. A number of animal models have been raised for studying T2DM, but the study has been restricted to only the biochemical level. The model is validated at biochemical, molecular and histopathological levels, which can be used for screening new therapeutics for the effective management of T2DM.
UVA Photoprotective Activity of Brown Macroalgae Sargassum cristafolium
Authors: Prasedya Eka Sunarwidhi , Syafitri Sundari Maulinda , Geraldine Brigitta A. F. D. , Hamdin Candra Dwipayana , Frediansyah Andri , Miyake Masao , Kobayashi Daisuke , Hazama Akihiro , Sunarpi Haji
Published: September 2019

Sunscreens today contain several synthetic UV (Ultraviolet) filter molecules to protect the skin epidermis from UV radiation damage. However, these molecules may create several negative effects on human skin. Due to this condition, there is an increase in the development of natural products to replace uses of these synthetic chemicals. Brown macroalgae Sargassum has been recently studied for its photoprotective activities. The purpose of this study is to investigate photoprotective activity of one of most abundant Sargassum species in Lombok coast; Sargassum cristaefolium. Spectrophotometry analysis with UV-VIS revealed the UV spectra absorbing capability of Sargassum cristaefolium (SC) in the UVA spectrum range (314–400 nm). Furthermore, spectrometry analyses with LC-MS revealed the existence of UV absorbing compound MAA-palythene. In correlation, SC ethanol extracts also demonstrate that it could protect DNA from UVA irradiation as analyzed in vitro in HeLa cell model. The effects of SC on UVA exposed-dorsal mice skin have also shown interesting results, as mice pretreated with SC before UVA exposure showed protective activity on the epidermal integrity similar as positive control. Whereas, UV exposed mice without SC or commercial products resulted in increased epidermal thickness, which is the common parameter of skin photoaging. In addition, pretreated mice with SC also show protective effects in the formation of collagen connective tissues. Overall, current results show promising photoprotective activity of SC against UV radiation. More advanced investigations of SC as a potential photoprotective agent would be reasonable for development of macroalgae-based natural skin protection products.
Epidemiology and Incidence of Pediatric Concussions in General Aspects of Life
Authors: Yaramothu Chang , Goodman Arlene M. , Alvarez Tara L.
Published: September 2019

Background: Concussions are one of the most common head injuries acquired within the pediatric population. While sport-related concussions are well documented, concussions within other aspects of a child’s life are not as well researched. The purpose of this study is to examine the incidence of a large pediatric concussion population in a broad range of daily activities. Methods: Patients’ gender and nature of injury were extracted from 1408 medical records of patients who were diagnosed with a concussion at Saint Peter’s Sports Medicine Institute. Statistical analyses were conducted for activities and environmental settings using chi-squared tests. Results: Concussions were most prevalent in organized sports (53.3%), followed by injuries within the following settings: school (16.5%), recreational (6.7%), motor vehicle collisions (6.6%), home (5.5%), and other (11.3%). Specifically, soccer (12.9%), school physical education (PE) class (10.6%), and football (9.8%) subcategories recorded the most incidences of concussion. For the PE class cohort (n = 149), significantly more females were diagnosed with a concussion compared to males (p < 0.001). Conclusions: PE-related concussions had the second highest incidence rate after organized sports. A significant gender difference was observed in PE class. Awareness about concussions and methods to reduce the risk of concussion is suggested for PE classes.
A Review and Scientometric Analysis of Global Building Information Modeling (BIM) Research in the Architecture, Engineering and Construction (AEC) Industry
Authors: Liu Ziwen , Lu Yujie , Peh Lu Chang
Published: September 2019

In the recent decade, Building Information Modeling (BIM) has widely been adopted in the Architectural, Engineering and Construction (AEC) industry and completely upended the way we build. While BIM continues gain momentum in the industry, it has also attracted increasing attention from researchers. However, most of the current study focuses on reviewing BIM for management, BIM for green building, BIM for infrastructure and BIM for Facilities Management (FM). There are few studies about Global BIM review and to discuss their complex inter-connections. In this study, we adopted a scientometric analysis method to review global BIM research during 2004–2019. In total, 1455 scholarly bibliographic records obtained from Web of Science Core Collection database were established for the analysis. This study has identified the top productive and influential researchers, research institutes, regions/countries, subject categories and journals in the BIM field. In addition, 11 clusters of global BIM research were also identified including construction project, green BIM, construction safety planning, automated IFC-based workflow and so on. The authors distinguished 11 clusters of global BIM research into three stages, namely formulating stage, accelerating stage and transforming stage. Furthermore, the authors reviewed the BIM policy of Singapore and observed there is a co-production relationship between evolution of BIM policy and global BIM research. These findings provide valuable information for researchers, practitioners and policymakers by visualizing the current progress in the research field of BIM and highlighting future research needs.
Effect of Operating Temperature, Pressure and Potassium Loading on the Performance of Silica-Supported Cobalt Catalyst in CO2 Hydrogenation to Hydrocarbon Fuel
Authors: Iloy Rama Achtar , Jalama Kalala
Published: September 2019

Potassium (1–5 wt.%)-promoted and unpromoted Co/SiO2 catalysts were prepared by impregnation method and characterized by nitrogen physisorption, temperature-programmed reduction (TPR), CO2 temperature-programmed desorption (TPD), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS) techniques. They were evaluated for CO2 hydrogenation in a fixed bed reactor from 180 to 300 °C within a pressure range of 1–20 bar. The yield for hydrocarbon products other than methane (C2+) was found to increase with an increase in the operating temperature and went through a maximum of approximately 270 °C. It did not show any significant dependency on the operating pressure and decreased at potassium loadings beyond 1 wt.%. Potassium was found to enhance the catalyst ability to adsorb CO2, but limited the reduction of cobalt species during the activation process. The improved CO2 adsorption resulted in a decrease in surface H/C ratio, the latter of which enhanced the formation of C2+ hydrocarbons. The highest C2+ yield was obtained on the catalyst promoted with 1 wt.% of potassium and operated at an optimal temperature of 270 °C and a pressure of 1 bar.
Insight into the Microstructure and Deactivation Effects on Commercial NiMo/γ-Al2O3 Catalyst through Aberration-Corrected Scanning Transmission Electron Microscopy
Authors: He Wenhui , Hu Anpeng , Qiu Limei , Wang Wei , Xiang Yanjuan , Han Wei , Xu Guangtong , Zhang Le , Zheng Aiguo
Published: September 2019

Atom-resolved microstructure variations and deactivation effects on the commercial NiMo/γ-Al2O3 catalysts were revealed by aberration-corrected scanning transmission electron microscope (Cs-STEM) equipped with enhanced energy dispersive X-ray spectroscopy (EDS). Structural information parallel to and vertical to the electron beam provides definitive insight toward an understanding of structure–activity relations. Under the mild to harsher reaction conditions, “fragment” structures (like metal single atoms, metal clusters, and nanoparticles) of commercial NiMo/γ-Al2O3 catalysts, gradually reduces, while MoS2 nanoslabs get longer and thinner. Such a result about active slabs leads to the reduction in the number of active sites, resulting in a significant decrease in activity. Likewise, the average atomic ratio of promoter Ni and Ni/(Mo + S) ratio of slabs decrease from 2.53% to 0.45% and from 0.0788 to 0.0326, respectively, by means of EDS under the same conditions stated above, reflecting the weakening of the promotional effect. XPS result confirms the existence of NixSy species in deactivated catalysts. This could be ascribed to the Ni segregation from active phase. Furthermore, statistical data give realistic coke behaviors associated with the active metals. With catalytic activity decreasing, the coke on the active metals regions tends to increase faster than that on the support regions. This highlights that the commercial NiMo/γ-Al2O3 catalyst during catalysis is prone to produce more coke on the active metal areas.
The Enzyme-Like Property and Photocatalytic Effect on α, α-Diphenyl-β-Picrylhydrazyl (DPPH) of CuPt Nanocomposite
Authors: Wen Tao , Yan Doudou , Meng Jie , Liu Jian , Xu Haiyan
Published: September 2019

With co-reduction method, a new nanocomposite consisting of Cu and Pt (CuPt) was prepared in household. The morphology of CuPt alloy was characterized by scanning electron microscope (SEM) and transmission electron microscope (TEM). The diameter of CuPt was ca. 125 nm measured by dynamic light scattering (DLS). The atom ratio of Cu to Pt was determined to be about 1.2 by energy-dispersive X-ray (EDX). Enzyme-like activities of CuPt, including peroxidase (POD)-like and ascorbic acid oxidase (AAO)-like activities were examined with UV-Vis-NIR spectrometer. The CuPt was found to interact with α, α-diphenyl-β-picrylhydrazyl (DPPH) in the presence or absence of AA. With irradiation by light emitting diode (LED) light, the photocatalysis effect of CuPt on DPPH was investigated. With the addition of histidine, it was proved that singlet oxygen had an important role in the interaction involving CuPt. The new nanocomposite and the properties suggest various potentials of application.
Differential Regulation of TLE3 in Sertoli Cells of the Testes during Postnatal Development
Authors: Lee Sangho , Jang Hoon , Moon Sohyeon , Lee Ok-Hee , Lee Sujin , Lee Jihyun , Park Chanhyeok , Seol Dong Won , Song Hyuk , Hong Kwonho , Kim Jin-Hoi , Uhm Sang Jun , Lee Dong Ryul , Lee Jeong-Woong , Choi Youngsok
Published: September 2019

Spermatogenesis is a process by which haploid cells differentiate from germ cells in the seminiferous tubules of the testes. TLE3, a transcriptional co-regulator that interacts with DNA-binding factors, plays a role in the development of somatic cells. However, no studies have shown its role during germ cell development in the testes. Here, we examined TLE3 expression in the testes during spermatogenesis. TLE3 was highly expressed in mouse testes and was dynamically regulated in different cell types of the seminiferous tubules, spermatogonia, spermatids, and Sertoli cells, but not in the spermatocytes. Interestingly, TLE3 was not detected in Sertoli cells on postnatal day 7 (P7) but was expressed from P10 onward. The microarray analysis showed that the expression of numerous genes changed upon TLE3 knockdown in a Sertoli cell line TM4. These include 1597 up-regulated genes and 1452 down-regulated genes in TLE3-knockdown TM4 cells. Ingenuity Pathway Analysis (IPA) showed that three factors were up-regulated and two genes were down-regulated upon TLE3 knockdown in TM4 cells. The abnormal expression of the three factors is associated with cellular malfunctions such as abnormal differentiation and Sertoli cell formation. Thus, TLE3 is differentially expressed in Sertoli cells and plays a crucial role in regulating cell-specific genes involved in the differentiation and formation of Sertoli cells during testicular development.
Nanoparticles Targeting STATs in Cancer Therapy
Authors: Ashrafizadeh Milad , Ahmadi Zahra , Kotla Niranjan G. , Afshar Elham Ghasemipour , Samarghandian Saeed , Mandegary Ali , Pardakhty Abbas , Mohammadinejad Reza , Sethi Gautam
Published: September 2019

Over the past decades, an increase in the incidence rate of cancer has been witnessed. Although many efforts have been made to manage and treat this life threatening condition, it is still one of the leading causes of death worldwide. Therefore, scientists have attempted to target molecular signaling pathways involved in cancer initiation and metastasis. It has been shown that signal transducers and activator of transcription (STAT) contributes to the progression of cancer cells. This important signaling pathway is associated with a number of biological processes including cell cycle, differentiation, proliferation and apoptosis. It appears that dysregulation of the STAT signaling pathway promotes the migration, viability and malignancy of various tumor cells. Hence, there have been many attempts to target the STAT signaling pathway. However, it seems that currently applied therapeutics may not be able to effectively modulate the STAT signaling pathway and suffer from a variety of drawbacks such as low bioavailability and lack of specific tumor targeting. In the present review, we demonstrate how nanocarriers can be successfully applied for encapsulation of STAT modulators in cancer therapy.
Low miR-150-5p and miR-320b Expression Predicts Reduced Survival of COPD Patients
Authors: Keller Andreas , Ludwig Nicole , Fehlmann Tobias , Kahraman Mustafa , Backes Christina , Kern Fabian , Vogelmeier Claus F. , Diener Caroline , Fischer Ulrike , Biertz Frank , Herr Christian , Jörres Rudolf A. , Lenhof Hans-Peter , Bals Robert , Meese Eckart
Published: September 2019

Chronic obstructive pulmonary disease (COPD) is associated with an increased risk of death, reducing life expectancy on average between 5 and 7 years. The survival time after diagnosis, however, varies considerably as a result of the heterogeneity of COPD. Therefore, markers that predict individual survival of COPD patients are of great value. We analyzed baseline molecular profiles and collected 54 months of follow-up data of the cohort study “COPD and SYstemic consequences-COmorbidities NETwork” (COSYCONET). Genome-wide microRNA signatures from whole blood collected at time of the inclusion in the study were generated for 533 COPD patients including patients that deceased during the 54-month follow-up period (n = 53) and patients that survived this period (n = 480). We identified two blood-born microRNAs (miR-150-5p and miR-320b) that were highly predictive for survival of COPD patients. The expression change was then confirmed by RT-qPCR in 245 individuals. Ninety percent of patients with highest expression of miR-150-5p survived the 54-month period in contrast to only 50% of patients with lowest expression intensity. Moreover, the abundance of the oncogenic miR-150-5p in blood of COPD patients was predictive for the development of cancer. Thus, molecular profiles measured at the time of a COPD diagnosis have a high predictive power for the survival of patients.
Advances in Ice-Templated and Freeze-Casted Ceramics
Authors: Deville Sylvain
Published: September 2019

Ice-templating, also known as freeze-casting, has become over the past 15 years a well-established materials processing route [...]
Growth and Correlation of the Physical and Structural Properties of Hexagonal Nanocrystalline Nickel Oxide Thin Films with Film Thickness
Authors: Hammad Ahmed H. , Abdel-wahab Mohamed Sh. , Vattamkandathil Sajith , Ansari Akhalakur Rahman
Published: September 2019

This study investigated nonstoichiometric nickel oxide thin films prepared via the DC-sputtering technique at different film thicknesses. The prepared films were characterized by a surface profiler for thickness measurement, X-ray diffraction (XRD) for film nature, atomic force microscopy (AFM) for film morphology and roughness, UV-visible-near infrared (UV-vis.-NIR) spectroscopy for optical transmittance spectra of the films, and the photoluminescence (PL) spectra of the prepared films were obtained. The measured film thickness increased from 150 to 503 nm as the deposition time increased. XRD detected the trigonal crystal system of NiO0.96. The crystallite sizes were mainly grown through (101) and (110) characteristic planes. NiO0.96 films have a spherical particle shape and their sizes decreases as the film thickness increased. The optical band gap values decrease from 3.817 to 3.663 eV when the film thickness increases. The refractive index was estimated from the Moss relation, while the high-frequency dielectric constant and the static dielectric constant were deduced from the empirical Adachi formula. The photoluminescence behavior of the studied films confirmed the photogeneration of an electron-hole in nickel and oxygen vacancies. Hence, this study confirms the presence of nickel oxide lattice in the hexagonal structure containing the defects originated from the nickel vacancies or the excess of oxygen.
Strategizing Information Systems: An Empirical Analysis of IT Alignment and Success in SMEs
Authors: Kitsios Fotis , Kamariotou Maria
Published: September 2019

IT investment is a crucial issue as it does not only influence the performance in Small-Medium Enterprises (SMEs) but it also helps executives to align business strategy with organizational performance. Admittedly, though, there is ineffective use of Information Systems (IS) due to a lack of strategic planning and of formal processes resulting in executives’ failure to develop IS plans and achieve long-term sustainability. Therefore, the purpose of this paper is to examine the phases of Strategic Information Systems Planning (SISP) process that contribute to a greater extent of success so that guidelines regarding the implementation of the process in SMEs can be provided. Data was collected by 160 IS executives in Greek SMEs during February and May 2017. Multivariate Regression Analysis was applied on the detailed items of the SISP process and success constructs. The results of this survey present that managers should be aware of the strategic use of IS planning so as to increase competitive advantage. Senior executives should choose the appropriate IT infrastructure (related to their business strategy and organizational structure), so as to align business strategy with organizational structure. The findings of this paper could help IS executives concentrate their efforts on business objectives and recognize the great value of the planning process on their business.
Changing by the Click: The Professional Development of UK Journalists
Authors: Murphy Colm
Published: September 2019

Changes in technology, audience engagement, the business model and ethical requirements have greatly expanded the skills required to be a professional journalist in the UK. At the same time, the esteem in which the profession is held by the public has diminished. This research used the UK journalism profession as a case study of change in a profession. It asked what were the changes in the profession since 2012. The research method includes an in-depth survey of 885 UK journalists, two previous similar surveys, interviews with stakeholders, national data and documentation. The study finds that UK journalist numbers, their educational attainment and workload has increased significantly in the period. The majority have become multiplatform journalists—working across at least two mediums like print and online. There has been a significant shift of job roles from traditional newsroom to a wide range of other organizations and some 36% of journalists are now self-employed. Diversity continues to be an issue with the profession having a white middle-class bias. The implications of these changes for future professional UK journalism education were then analyzed. They include the need to develop a national continuous professional development framework, better cooperation amongst competing accrediting bodies to enhance the public trust in journalists and greater flexibility on the professional pathways to senior qualifications.
Neoteric Fuzzy Control Stratagem and Design of Chopper fed Multilevel Inverter for Enhanced Voltage Output Involving Plug-In Electric Vehicle (PEV) Applications
Authors: Poyyamani Sunddararaj Suvetha , S. Rangarajan Shriram , Gopalan Swaminathan
Published: September 2019

The utilization of plug-in electric vehicles (PEV) has started to garner more attention worldwide considering the environmental and economic benefits. This has led to the invention of new technologies and motifs associated with batteries, bidirectional converters and inverters for Electric Vehicle applications. In this paper, a novel design and control of chopper circuit is proposed and configured with the series and parallel connection of the power electronic based switches for two-way operation of the converter. The bidirectional action of the proposed converter makes it suitable for plug-in electric vehicle applications as the grid is becoming smarter. The DC–DC converter is further interfaced with the designed multilevel inverter (MLI). The reduced switches associated with the novel design of MLI have overcome the cons associated with the conventional inverters in terms of enhanced performance in the proposed design. Further, novel control strategies have been proposed for the DC–DC converter based on Proportional Integral (PI) and Fuzzy based control logic. For the first time, the performance of the entire system is evaluated based on the comparison of proposed PI, fuzzy, and hybrid controllers. New rules have been formulated for the Fuzzy based controllers that are associated with the Converter design. This has further facilitated the interface of bidirectional DC–DC converter with the proposed MLI for an enhanced output voltage. The results indicate that the proposed hybrid controller provides better performance in terms of voltage gain, ripple, efficiency and overall aspects of power quality that forms the crux for PEV applications. The novelty of the design and control of the overall topology has been manifested based on simulation using MATLAB/SIMULINK.
Comparing Negative Impacts of Prunus serotina, Quercus rubra and Robinia pseudoacacia on Native Forest Ecosystems
Authors: Gentili Rodolfo , Ferrè Chiara , Cardarelli Elisa , Montagnani Chiara , Bogliani Giuseppe , Citterio Sandra , Comolli Roberto
Published: September 2019

The introduction of invasive alien plant species (IAPS) can modify plant-soil feedback, resulting in an alteration of the abiotic and biotic characteristics of ecosystems. Prunus serotina, Quercus rubra and Robinia pseudoacacia are IAPS of European temperate forests, where they can become dominant and suppress the native biodiversity. Assuming that the establishment of these invasive species may alter native forest ecosystems, this study comparatively assessed their impact on ecosystems. This study further investigated plant communities in 12 forest stands, dominated by the three IAPS and native trees, Quercus robur and Carpinus betulus (three plots per forest type), in Northern Italy, and collected soil samples. The relationships between the invasion of the three IAPS and modifications of humus forms, soil chemical properties, soil biological quality, bacterial activity and plant community structure and diversity (α-, β-, and γ-diversity) were assessed using one-way ANOVA and redundancy analyses (RDA). Our comparative study demonstrated that invaded forests often had unique plant and/or soil properties, relative to native forests, and the degree of dissimilarity depended on the invasive species. Particularly, Q. rubra is related to major negative impacts on soil organic horizons and low/modified levels of microarthropod and plant biodiversity. R. pseudoacacia is associated with an altered base content of soil and, in turn, with positive feedback to the soil biological quality (QBS-ar) and plant diversity, but with a high cover compared with other alien plant species. P. serotina is associated with intermediate impacts and exhibits a plant species assemblage that is more similar to those of native forest stands. Our work suggests impact-based management decisions for the three investigated IAPS, since their effects on the diversity and composition of resident ecosystems are very different.
Modeling the Influence of Eucalypt Plantation on Wildfire Occurrence in the Brazilian Savanna Biome
Authors: Galizia Luiz Felipe de Castro , Rodrigues Marcos
Published: September 2019

In the last decades, eucalypt plantations are expanding across the Brazilian savanna, one of the most frequently burned ecosystems in the world. Wildfires are one of the main threats to forest plantations, causing economic and environmental loss. Modeling wildfire occurrence provides a better understanding of the processes that drive fire activity. Furthermore, the use of spatially explicit models may promote more effective management strategies and support fire prevention policies. In this work, we assessed wildfire occurrence combining Random Forest (RF) algorithms and cluster analysis to predict and detect changes in the spatial pattern of ignition probability over time. The model was trained using several explanatory drivers related to fire ignition: accessibility, proximity to agricultural lands or human activities, among others. Specifically, we introduced the progression of eucalypt plantations on a two-year basis to capture the influence of land cover changes over fire likelihood consistently. Fire occurrences in the period 2010–2016 were retrieved from the Brazilian Institute of Space Research (INPE) database. In terms of the AUC (area under the Receiver Operating Characteristic curve), the model denoted fairly good predictive accuracy (AUC ≈ 0.72). Results suggested that fire occurrence was mainly linked to proximity agricultural and to urban interfaces. Eucalypt plantation contributed to increased wildfire likelihood and denoted fairly high importance as an explanatory variable (17% increase of Mean Square Error [MSE]). Nevertheless, agriculture and urban interfaces proved to be the main drivers, contributing to decreasing the RF’s MSE in 42% and 38%, respectively. Furthermore, eucalypt plantations expansion is progressing over clusters of high wildfire likelihood, thus increasing the exposure to wildfire events for young eucalypt plantations and nearby areas. Protective measures should be focus on in the mapped Hot Spot zones in order to mitigate the exposure to fire events and to contribute for an efficient initial suppression rather than costly firefighting.
Joint Optimization of Pico-Base-Station Density and Transmit Power for an Energy-Efficient Heterogeneous Cellular Network
Authors: Yang Jie , Pan Ziyu , Xu Hengfei , Hu Han
Published: September 2019

Heterogeneous cellular networks (HCNs) have emerged as the primary solution for explosive data traffic. However, an increase in the number of base stations (BSs) inevitably leads to an increase in energy consumption. Energy efficiency (EE) has become a focal point in HCNs. In this paper, we apply tools from stochastic geometry to investigate and optimize the energy efficiency (EE) for a two-tier HCN. The average achievable transmission rate and the total power consumption of all the BSs in a two-tier HCN is derived, and then the EE is formulated. In order to maximize EE, a one-dimensional optimization algorithm is used to optimize picocell BS density and transmit power. Based on this, an alternating optimization method aimed at maximizing EE is proposed to jointly optimize transmit power and density of picocell BSs. Simulation results validate the accuracy of the theoretical analysis and demonstrate that the proposed joint optimization method can obviously improve EE.
Identification and Structural Elucidation of Anti-Inflammatory Compounds from Chinese Olive (Canarium Album L.) Fruit Extracts
Authors: Kuo Yueh-Hsiung , Yeh Yu-Te , Pan Sih-Ying , Hsieh Shu-Chen
Published: September 2019

Chinese olive (Canarium album L.), a rich source of polyphenols, can be used as a functional food ingredient. We previously showed that the ethyl acetate fraction of this extract (CO-EtOAc) is an effective anti-inflammatory agent. Therefore, here, we aimed to screen the bioactive fractions extracted from CO-EtOAc using different isolation techniques, and purify the bioactive compounds based on their cytotoxic and anti-inflammatory abilities. CO-EtOAc was fractionated using silica gel and Sephadex column chromatography, and the active compounds were isolated and purified by high-performance liquid chromatography (HPLC). The structures of the resulting compounds were identified using proton nuclear magnetic resonance (NMR) spectra. Activity-directed fractionation and purification were used to identify the following active compounds with anti-inflammatory effects using lipopolysaccharide (LPS)-stimulated mouse macrophages: sitoindoside I, amentoflavone, tetrahydroamentoflavone and protocatechuic acid. For the first time, sitoindoside I and tetrahydroamentoflavone were isolated from Chinese olive, and the anti-inflammatory compounds of CO-EtOAc were identified, suggesting its potential for used as a health food ingredient.