bluuebunny/crossref_metadata_2025 huggingface dataset:
Domestic fear beyond traumatic terror: understanding mothers’ everyday experiences of recurring fear in the context of domestic violence
Authors: Moussion-Esteve Adeline
Published: October 2022

This article offers an empirical critique of trauma-informed fear models by documenting how mothers experienced repetitive fear of domestic violence in France. I challenge the reduction of victims’ responses to traumatic ‘terror’ and suggest that the neurological fear models which circulate in training and advocacy discourses fail to acknowledge the domestic setting and the resources on which they draw to respond to fear. Analysing ethnographic data, the article adopts a structural theory of emotion and domestic violence. I draw on Jack Barbalet’s notion of fear containment and rework his model by applying it to non-elite and individual mothers through what I call ‘instrumental’ counterchallenge and submissiveness. I show that their fear practices are combined with fear containment. The article analyses fear as an occasion for knowledge acquisition and an auxiliary for instrumental action. The article highlights the hidden fear responses that go unnoticed when analysis prominently relies on neurological trauma: mothers act on their fears to confirm or overrule fearful anticipations and they experience fear as an occasion for knowledge acquisition to guide future action.
Imagining and co-creating futures of sustainable consumption and society
Authors: Jensen Charlotte Louise , Oldin Frederikke , Andersen Gregers
Published: October 2022

With the increasing pressure on the climate from human activities, it is urgent to envision and facilitate radically different ways of life that allow for significantly lower greenhouse gas emissions. This only happens if policy and action initiatives go beyond discursive practices that treat climate change mitigation as a matter of technological fixes, and individual behavioural change. Decades of research on the sociology of consumption show that lifestyle changes are as much about changes to norms and ideas about what ‘a good life’ is as they are about access to the necessary competences, infrastructures and sustainable alternatives. Acknowledging the growing body of sociological research that seeks to understand how expectations of the future shape processes of social change in the present, more attention could be paid to the role of discourse, narratives and storying when it comes to making efforts towards carbon neutral climate futures. Taking as a point of departure a futuring methodology called the Future Travel Workshop, this article discusses the potential role of stories through Moezzi et al’s (2017) notion of stories as inquiry and stories as process for futurity. Comprised of three sessions, the workshop explores what future everyday lives and societies might look and feel like. Each session is framed by a set of narratives on climate related problems of the present, and how these problems affect the way we think about futures. Interestingly, the participants’ imagined futures went from technologically utopic and tension-free towards tense and radically different conceptions of the needed levels of societal reorganisation.
Coarse-scale optoretinography (CoORG) with extended field-of-view for normative characterization
Authors: Jiang Xiaoyun , Liu Teng , Pandiyan Vimal Prabhu , Slezak Emily , Sabesan Ramkumar
Published: October 2022

Optoretinography (ORG) has the potential to be an effective biomarker for light-evoked retinal activity owing to its sensitive, objective, and precise localization of retinal function and dysfunction. Many ORG implementations have used adaptive optics (AO) to localize activity on a cellular scale. However, the use of AO restricts field-of-view (FOV) to the isoplanatic angle, necessitating the montaging of multiple regions-of-interest to cover an extended field. In addition, subjects with lens opacities, increased eye movements and decreased mobility pose challenges for effective AO operation. Here, we developed a coarse-scale ORG (CoORG) system without AO, which accommodates FOVs up to 5.5 deg. in a single acquisition. The system is based on a line-scan spectral domain OCT with volume rates of up to 32 Hz (16,000 B-frames per second). For acquiring ORGs, 5.5 deg. wide OCT volumes were recorded after dark adaptation and two different stimulus bleaches. The stimulus-evoked optical phase change was calculated from the reflections encasing the cone outer segments and its variation was assessed vs. eccentricity in 12 healthy subjects. The general behavior of ΔOPL vs. time mimicked published reports. High trial-to-trial repeatability was observed across subjects and with eccentricity. Comparison of ORG between CoORG and AO-OCT based ORG at 1.5°, 2.5°, and 3.5° eccentricity showed an excellent agreement in the same 2 subjects. The amplitude of the ORG response decreased with increasing eccentricity. The variation of ORG characteristics between subjects and versus eccentricity was well explained by the photon density of the stimulus on the retina and the outer segment length. Overall, the high repeatability and rapid acquisition over an extended field enabled the normative characterization of the cone ORG response in healthy eyes, and provides a promising avenue for translating ORG for widespread clinical application.
Spin exchange optically pumped nuclear spin self compensation system for moving magnetoencephalography measurement
Authors: Chen Yao , Zhao Libo , Ma Yintao , Yu Mingzhi , Wang Yanbin , Zhang Ning , Wei Kai , Jiang Zhuangde
Published: October 2022

Recording moving magnetoencephalograms (MEGs ), in which a person’s head can move freely as the brain’s magnetic field is recorded, has been a key subject in recent years. Here, we describe a method based on an optically pumped atomic co-magnetometer (OPACM) for recording moving MEGs. In the OPACM, hyper-polarized nuclear spins produce a magnetic field that blocks the background fluctuation low-frequency magnetic field noise while the rapidly changing MEG signal is recorded. In this study, the magnetic field compensation was studied theoretically, and we found that the compensation is closely related to several parameters such as the electron spin magnetic field, nuclear spin magnetic field, and holding magnetic field. Furthermore, the magnetic field compensation was optimized based on a theoretical model . We also experimentally studied the magnetic field compensation and measured the responses of the OPACM to different magnetic field frequencies. We show that the OPACM clearly suppresses low-frequency (under 1 Hz) magnetic fields. However, the OPACM responses to magnetic field frequencies around the band of the MEG. A magnetic field sensitivity of 3 fT/Hz1/2 was achieved. Finally, we performed a simulation of the OPACM during utilization for moving MEG recording. For comparison, the traditional compensation system for moving MEG recording is based on a coil that is around 2 m in dimension , while our compensation system is only 2 mm in dimension .
Assessment of standard HIV testing services delivery to injured persons seeking emergency care in Nairobi, Kenya: A prospective observational study
Authors: Aluisio Adam R. , Sugut Janet , Kinuthia John , Bosire Rose , Ochola Eric , Ngila Beatrice , Ojuka Daniel K. , Lee J. Austin , Maingi Alice , Guthrie Kate M. , Liu Tao , Mugambi Mary , Katz David A. , Farquhar Carey , Mello Michael J.
Published: October 2022

Emergency departments (EDs) in Africa are contact points for key groups for HIV testing services (HTS) but understanding of ED-testing delivery is limited which may impeded program impacts. This study evaluated the offering and uptake of standard HTS among injured persons seeking ED care at Kenyatta National Hospital (KNH) in Nairobi, Kenya. An ED population of adult injured persons was prospectively enrolled (1 March—25 May 2021) and followed through ED disposition. Participants requiring admission were followed through hospital discharge and willing participants were contacted at 28-days for follow up. Data on population characteristics and HTS were collected by personnel distinct from clinicians responsible for standard HTS. Descriptive analyses were performed and prevalence values with 95% confidence intervals (CI) were calculated for HIV parameters. The study enrolled 646 participants. The median age was 29 years with the majority male (87.8%). Most ED patients were discharged (58.9%). A prior HIV diagnosis was reported by 2.3% of participants and 52.7% reported their last testing as >6 months prior. Standard ED-HTS were offered to 49 or 8.6% of participants (95% CI: 5.8–9.9%), among which 89.8% accepted. For ED-tested participants 11.4% were newly diagnosed with HIV (95% CI: 5.0–24.0%). Among 243 participants admitted, testing was offered to 6.2% (95% CI: 3.9–9.9%), with 93.8% accepting. For admitted participants tested 13.3% (95% CI: 4.0–35.1%) were newly diagnosed (all distinct from ED cases). At 28-day follow up an additional 22 participants reported completing testing since ED visitation, with three newly diagnosed. During the full follow-up period the HIV prevalence in the population tested was 10.3% (95% CI: 5.3–19.0%); all being previously undiagnosed. Offering of standard HTS was infrequent, however, when offered, uptake and identification of new HIV diagnoses were high. These data suggest that opportunities exist to improve ED-HTS which could enhance identification of undiagnosed HIV.
Mapping climate change’s impact on cholera infection risk in Bangladesh
Authors: Kruger Sophia E. , Lorah Paul A. , Okamoto Kenichi W.
Published: October 2022

Several studies have investigated howVibrio choleraeinfection risk changes with increased rainfall, temperature, and water pH levels for coastal Bangladesh, which experiences seasonal surges in cholera infections associated with heavy rainfall events. While coastal environmental conditions are understood to influenceV.choleraepropagation within brackish waters and transmission to and within human populations, it remains unknown how changing climate regimes impact the risk for cholera infection throughout Bangladesh. To address this, we developed a random forest species distribution model to predict the occurrence probability of cholera incidence within Bangladesh for 2015 and 2050. We developed a random forest model trained on cholera incidence data and spatial environmental raster data to be predicted to environmental data for the year of training (2015) and 2050. From our model’s predictions, we generated risk maps for cholera occurrence for 2015 and 2050. Our best-fitting model predicted cholera occurrence given elevation and distance to water. Generally, we find that regions within every district in Bangladesh experience an increase in infection risk from 2015 to 2050. We also find that although cells of high risk cluster along the coastline predominantly in 2015, by 2050 high-risk areas expand from the coast inland, conglomerating around surface waters across Bangladesh, reaching all but the northwestern-most district. Mapping the geographic distribution of cholera infections given projected environmental conditions provides a valuable tool for guiding proactive public health policy tailored to areas most at risk of future disease outbreaks.
Predicting the burden of cancer in Switzerland up to 2025
Authors: Trächsel Bastien , Rapiti Elisabetta , Feller Anita , Rousson Valentin , Locatelli Isabella , Bulliard Jean-Luc
Published: October 2022

Predicting the short-term evolution of the number of cancers is essential for planning investments and allocating health resources. The objective of this study was to predict the numbers of cancer cases and of the 12 most frequent cancer sites, and their age-standardized incidence rates, for the years 2019–2025 in Switzerland. Projections of the number of malignant cancer cases were obtained by combining data from two sources: forecasts of national age-standardized cancer incidence rates and population projections from the Swiss Federal Statistical Office. Age-standardized cancer incidence rates, approximating the individual cancer risk, were predicted by a low-order Autoregressive Integrated Moving Average (ARIMA) model. The contributions of changes in cancer risk (epidemiological component) and population aging and growth (demographic components) to the projected number of new cancer cases were each quantified. Between 2018 and 2025, age-standardized cancer incidence rates are predicted to stabilize for men and women at around 426 and 328/100,000, respectively (<1% change). These projected trends are expected for most cancer sites. The annual number of cancers is expected to increase from 45,676 to 52,552 (+15%), more so for men (+18%) than for women (+11%). These increases are almost entirely due to projected changes in population age structure (+12% for men and +6% for women) and population growth (+6% for both sexes). The rise in numbers of expected cancers for each site is forecast to range from 4.15% (thyroid in men) to 26% (bladder in men). While ranking of the three most frequent cancers will remain unchanged for men (1st prostate, 2nd lung, 3rd colon-rectum), colorectal cancer will overtake by 2025 lung cancer as the second most common female cancer in Switzerland, behind breast cancer. Effective and sustained prevention measures, as well as infrastructural interventions, are required to counter the increase in cancer cases and prevent any potential shortage of professionals in cancer care delivery.
Disability-adjusted life years associated with chronic comorbidities among people living with and without HIV: Estimating health burden in British Columbia, Canada
Authors: Nanditha Ni Gusti Ayu , Zhu Jielin , Wang Lu , Kopec Jacek , Hogg Robert S. , Montaner Julio S. G. , Lima Viviane D.
Published: October 2022

Life span of people living with HIV (PLWH) has increased dramatically with the advent of modern antiretroviral therapy. As a result, comorbidities have emerged as a significant concern in this population. To describe the burden of chronic comorbidities among PLWH and HIV-negative individuals in British Columbia (BC), Canada, we estimated disability-adjusted life years (DALYs) related to these comorbidities. Based on a population-based cohort in BC, antiretroviral-treated adult PLWH and 1:4 age-sex-matched HIV-negative controls were followed for ≥1 year during 2001–2012. DALYs combined years of life lost to premature mortality (YLLs) and due to disability (YLDs), and were estimated following the Global Burden of Diseases’ approaches. DALYs associated with non-AIDS-defining cancers, diabetes, osteoarthritis, hypertension, dementia, cardiovascular (CVD), kidney, liver and chronic obstructive pulmonary diseases were each measured for 2008–2012. Among PLWH, DALYs attributed to non-AIDS-related cancers were also estimated for 2013–2020. We observed that at baseline, our matched cohort consisted of 82% males with a median age of 40 years (25th-75th percentiles: 34–47). During 2008–2012, 7042 PLWH and 30,640 HIV-negative individuals were alive, where PLWH experienced a twofold higher DALYs associated with chronic comorbidities (770.2 years/1000 people [95% credible intervals: 710.2, 831.6] vs. 359.0 [336.0, 382.2]). Non-AIDS-defining cancers and CVD contributed the highest DALYs in both populations, driven by YLLs rather than YLDs. Among PLWH, we estimated increasing DALYs attributable to non-AIDS-defining cancers with 91.7 years/1000 people (77.4, 106.0) in 2013 vs. 97.6 (81.0, 115.2) in 2020. In this study, we showed that PLWH experience a disproportionate burden of chronic comorbidities compared to HIV-negative individuals. The observed disparities may relate to differential health behaviors, residual HIV-related inflammation, and ART-related toxicities. As aging shapes future healthcare needs, our findings highlight the need to enhance prevention and management of comorbidities as part of HIV care.
Impact of antivenom administration on the evolution of cutaneous lesions in loxoscelism: A prospective observational study
Authors: Malaque Ceila M. S. , Novaes Christina T. G. , Piorelli Roberta O. , Risk Jose Y. , Murad Jefferson C. , Lara Amanda N. , Virgulino Cristiana C. , Miyaji Karina T. , Santoro Marcelo L.
Published: October 2022

Background

Spiders of the genus Loxosceles are distributed throughout tropical and temperate regions worldwide. Loxosceles spp. bites may evolve to necrosis, with or without intravascular hemolysis. There is no consensus regarding the best treatment to prevent necrosis. The objective of this study was to evaluate the factors associated with the development of necrosis and the impact that antivenom administration has on the evolution of cutaneous loxoscelism.

Methodology/Principal findings

This was a prospective observational study carried out at a referral center for envenoming. Over a 6-year period, we included 146 patients with a presumptive or definitive diagnosis of loxoscelism. Depending on the symptom severity, a polyvalent anti-arachnid antivenom was administered or not—in 74 cases (50.7%) and 72 cases (49.3%), respectively. Cutaneous and systemic manifestations were assessed at admission and weekly thereafter. Adverse reactions to the antivenom were also evaluated. Cutaneous loxoscelism was observed in 141 cases (96.6%), and the spider was identified in 29 (19.9%). The mean time from bite to antivenom administration was 41.6 ± 27.4 h. After discharge, 130 patients (90.9%) were treated with corticosteroids, antihistamines and analgesics being prescribed as needed. The probability of developing necrosis was significantly lower among the patients who were admitted earlier, as well as among those who received antivenom (p = 0.0245). Among the 74 patients receiving antivenom, early and delayed adverse reactions occurred in seven (9.5%) and four (5.4%), respectively. Local infection was observed only in three (2.3%) of the 128 patients for whom that information was available.

Conclusions/Significance

Necrosis after a Loxosceles sp. bite appears to more common when hospital admission is delayed or when antivenom is not administered. In addition, the administration of a polyvalent anti-arachnid antivenom appears to be safe, with a relatively low rate of adverse reactions.
Pilot clinical and pharmacokinetic study of Δ9-Tetrahydrocannabinol (THC)/Cannabidiol (CBD) nanoparticle oro-buccal spray in patients with advanced cancer experiencing uncontrolled pain
Authors: Clarke Stephen , Butcher Belinda E. , McLachlan Andrew J. , Henson Jeremy D. , Rutolo David , Hall Sean , Vitetta Luis
Published: October 2022

This pilot study aimed to assess the safety, tolerability, pharmacokinetics and exploratory analgesic effect of a novel water-soluble oro-buccal nanoparticle spray of a cannabis-based medicine (MDCNS-01) in patients with advanced incurable malignancy with unrelieved pain from opioid analgesic. The study was a non-blinded single arm 2 stage study. Stage I was a single escalating dose (n = 5) [2.5 mg Δ9-THC and 2.5 mg CBD) versus a 3-fold escalated dose. Stage II was an up-titrated dose in patients with advanced cancers and intractable pain (n = 25). During Stage I with an increased cannabis-based medicine dose, maximum observed plasma concentrations of cannabinoids were dose dependant. The water-soluble formulation in the current study resulted in a higher median (min, max) systemic exposure of Δ9-THC than CBD (AUC from 2.5 mg each of Δ9-THC and CBD, was 1.71 ng mL.h−1(1.1, 6.6) and 0.65 ng mL.h−1(0.49, 4.1), respectively). During stage II a subgroup of patients diagnosed with breast and prostate cancers with bone metastases, had the highest mean pain score improvement from baseline of 40% (unadjusted) and 33% (adjusted for rescue medication use). For all patients the most reported adverse events were mild or moderate drowsiness affecting 11 (44%) and 4 (6%) patients, respectively, and nausea and vomiting that affected 18 (72%) patients. The water-soluble cannabis-based medicine provided acceptable bioavailability for Δ9-THC/CBD, appeared safe and tolerable in advanced incurable cancers with uncontrolled pain with preliminary evidence of analgesic efficacy.
Corneal epithelium in keratoconus underexpresses active NRF2 and a subset of oxidative stress-related genes
Authors: Lupasco Tatiana , He Zhiguo , Cassagne Myriam , Sagnial Tomy , Brion Lise , Fournié Pierre , Gain Philippe , Thuret Gilles , Allouche Michèle , Malecaze François , Simon Michel , Galiacy Stéphane D.
Published: October 2022

Keratoconus (KC) is a multifactorial progressive ectatic disorder characterized by local thinning of the cornea, leading to decreased visual acuity due to irregular astigmatism and opacities. Despite the evolution of advanced imaging methods, the exact etiology of KC remains unknown. Our aim was to investigate the involvement of corneal epithelium in the pathophysiology of the disease. Corneal epithelial samples were collected from 23 controls and from 2 cohorts of patients with KC: 22 undergoing corneal crosslinking (early KC) and 6 patients before penetrating keratoplasty (advanced KC). The expression of genes involved in the epidermal terminal differentiation program and of the oxidative stress pathway was assessed by real time PCR analysis. Presence of some of the differentially expressed transcripts was confirmed at protein level using immunofluorescence on controls and advanced KC additional corneal samples. We found statistically significant under-expression in early KC samples of some genes known to be involved in the mechanical resistance of the epidermis (KRT16, KRT14, SPRR1A, SPRR2A, SPRR3, TGM1 and TGM5) and in oxidative stress pathways (NRF2, HMOX1 and HMOX2), as compared to controls. In advanced KC samples, expression of SPRR2A and HMOX1 was reduced. Decreased expression of keratin (KRT)16 and KRT14 proteins was observed. Moreover, differential localization was noted for involucrin, another protein involved in the epidermis mechanical properties. Finally, we observed an immunofluorescence staining for the active form of NRF2 in control epithelia that was reduced in KC epithelia. These results suggest a defect in the mechanical resistance and the oxidative stress defense possibly mediated via the NRF2 pathway in the corneal keratoconic epithelium.
Soluble chitosan derivative treats wound infections and promotes wound healing in a novel MRSA-infected porcine partial-thickness burn wound model
Authors: Egro Francesco , Repko Alex , Narayanaswamy Vidya , Ejaz Asim , Kim Deokyeol , Schusterman M. Asher , Loughran Allister , Ayyash Ali , Towsend Stacy M. , Baker Shenda , Ziembicki Jenny , Marra Kacey , Rubin Peter
Published: October 2022

Burns are physically debilitating and potentially fatal injuries. The most common etiology of burn wound infections in the US is methicillin-resistantStaphylococcus aureus(MRSA), which is particularly recalcitrant when biofilms form. The current standard of care, silver sulfadiazine (SSD) is effective in reducing bacterial load, but less effective in improving burn wound healing. New treatments that can manage infection while simultaneously improving healing would provide a benefit in the treatment of burns. Porcine models are frequently used as a model for human wound healing but can be expensive due to the need to separate wounds to avoid cross contamination. The porcine model developed in this study offers the capability to study multiple partial thickness burn wound (PTBW) sites on a single animal with minimal crosstalk to study wound healing, infection, and inflammation. The current study evaluates a wound rinse and a wound gel formulated with a non-toxic, polycationic chitosan derivative that is hypothesized to manage infection while also promoting healing, providing a potential alternate to SSD. Studiesin vitroand in this PTBW porcine model compare treatment with the chitosan derivative formulations to SSD. The wound rinse and wound gel are observed to disrupt mature MRSA biofilmsin vitroand reduce the MRSA loadin vivo when compared to that of the standard of care.In vivodata further show increased re-epithelialization and faster healing in burns treated with wound rinse/gel as compared to SSD. Taken together, the data demonstrate the potential of the wound rinse/gel to significantly enhance healing, promote re-epithelialization, and reduce bacterial burden in infected PTBW using an economical porcine model.
Does financial inclusion help alleviate household poverty and vulnerability in China?
Authors: Jiang Youxue , Liu Yangyi
Published: October 2022

This paper investigates the impact of financial Inclusion on household poverty and vulnerability by constructing a household financial inclusion index using the China Household Finance Survey 2015. It is found that financial Inclusion significantly reduces the probability of poverty and vulnerability of households and has a more significant impact on vulnerable groups such as rural and urban low-income people. Further, financial Inclusion has a more significant effect on poor families that do not receive government support for poverty alleviation and can complement co-insurance mechanisms to help families better cope with vulnerabilities caused by synergistic community shocks. Finally, promoting entrepreneurship and improving risk management capabilities are the main channels of financial Inclusion.
Experiences that influence how trained providers support women with breastfeeding: A systematic review of qualitative evidence
Authors: Chesnel Mary Jo , Healy Maria , McNeill Jenny
Published: October 2022

Introduction

There is a need to improve breastfeeding support interventions as although many are evidence-based, a sequential increase in breastfeeding rates is not evident. It is crucial to understand why the implementation of evidence-based guidelines in practice does not always translate to positive experiences for women and improve breastfeeding rates. This systematic review aims to synthesise breastfeeding support experiences of trained support providers and their impact on breastfeeding support practices.

Methods

A strategy was developed to search seven databases including Medline and CINAHL and grey literature for qualitative studies. Studies eligible for inclusion reported professional and trained peer experiences of supporting women to breastfeed. PRISMA guidelines were followed and included studies were quality appraised using the CASP Qualitative Checklist. A thematic synthesis of included studies was undertaken and confidence in the review findings was assessed using the CERQual tool. The study protocol, registered in the International Prospective Register of Systematic Reviews PROSPERO registration number: CRD42020207380, has been peer reviewed and published.

Findings

A total of 977 records were screened, which identified 18 studies (21 papers) eligible for inclusion comprising 368 participants. Following quality appraisal, all studies were deemed suitable for inclusion. The thematic synthesis resulted in four analytical themes: 1) A personal philosophy of breastfeeding support 2) Teamwork and tensions in practice 3) Negotiating organisational constraints and 4) Encounters with breastfeeding women. Findings demonstrated that a range of experiences influence practice, and practice evolves on continued exposure to such experiences. The potential of each experience to facilitate or inhibit breastfeeding support provision is fluid and context specific.

Conclusions

Experiences, as named above, are modifiable factors contributing to the development of a philosophy of breastfeeding support based on what the provider believes works and is valuable in practice. Further research is required into the range of factors which underpin context-specific breastfeeding support practice, to improve both women’s experiences and intervention effectiveness.
Winners and losers from Pfizer and Biontech’s vaccine announcement: Evidence from S&P 500 (Sub)sector indices
Authors: Kapar Burcu , Buigut Steven , Rana Faisal
Published: October 2022

This study explores how the US stock market reacted to the news of a successful development of vaccine by Pfizer and Biontech on November 9, 2020. In particular, the study analyses the effect of the vaccine announcement on 11 sector indices and 79 subsector indices. A key contribution of the present study is to provide a deeper subsector level of analysis lacking in existing literature. An event study approach is applied in identifying abnormal returns due to the November 9th vaccine announcement. Several event periods (-1, 0, 1, 2, 3, 0-1, 0-3) are analysed to provide a more complete picture of the effects. Based on analysis, it is established that there are considerable inter and intra sectoral variations in the impact of the vaccine news. The results show that the impact follows a clear pattern. The sectors that were hit hardest by the pandemic such as energy, financials, as well as subsectors like hotels and casinos, benefited the most from positive vaccine news. Subsectors that gained from the pandemic such as airfreight, household appliances and computers and electronics retail were depressed the most by the news. These findings suggest that while the availability of vaccines is expected to help steer economies gradually to normalcy, the re-adjustment is likely to be asymmetric across subsectors. While some subsectors expect to expand as these industries recover from the contraction inflicted by the COVID-19 environment, other subsectors expect adjustment losses as these industries shed off the above average gains driven by the COVID-19 environment.
Prevalence and concentration of Campylobacter in faeces of dairy cows: A systematic review and meta-analysis
Authors: Knipper Anna-Delia , Ghoreishi Narges , Crease Tasja
Published: October 2022

The consumption of raw milk from dairy cows has caused multiple food-borne outbreaks of campylobacteriosis in the European Union (EU) since 2011. Cross-contamination of raw milk through faeces is an important vehicle for transmission ofCampylobacterto consumers. This systematic review and meta-analysis, aimed to summarize data on the prevalence and concentration ofCampylobacterin faeces of dairy cows. Suitable scientific articles published up to July 2021 were identified through a systematic literature search and subjected to screening and quality assessment. Fifty-three out of 1338 identified studies were eligible for data extraction and 44 were further eligible for meta-analysis. The pooled prevalence was calculated in two different meta-analytic models: a simple model based on one average prevalence estimate per study and a multilevel meta-analytic model that included all prevalence outcomes reported in each study (including different subgroups of e.g. health status and age of dairy cows). The results of the two models were significantly different with a pooled prevalence estimate of 29%, 95% CI [23–36%] and 51%, 95% CI [44–57%], respectively. The effect of sub-groups on prevalence were analyzed with a multilevel mixed-effect model which showed a significant effect of the faecal collection methods andCampylobacterspecies on the prevalence. A meta-analysis on concentration data could not be performed due to the limited availability of data. This systematic review highlights important data gaps and limitations in current studies and variation of prevalence outcomes between available studies. The included studies used a variety of methods for sampling, data collection and analysis ofCampylobacterthat added uncertainty to the pooled prevalence estimates. Nevertheless, the performed meta-analysis improved our understanding ofCampylobacterprevalence in faeces of dairy cows and is considered a valuable basis for the further development of quantitative microbiological risk assessment models forCampylobacterin (raw) milk and food products thereof.
Optimal path planning of Unmanned Aerial Vehicles (UAVs) for targets touring: Geometric and arc parameterization approaches
Authors: Forkan Mohammad , Rizvi Mohammed Mustafa , Chowdhury Mohammad Abul Mansur
Published: October 2022

The path planning problem for unmanned aerial vehicles (UAVs) is important for scheduling the UAV missions. This paper presents an optimal path planning model for UAV to control its direction during target touring, where UAV and target are at the same altitude. Geometric interpretation of the given model is provided when the vehicles consider connecting an initial position to the destination position with specific target touring. We develop a nonlinear constrained model based on an arc parameterization approach to determine the UAV’s optimal path touring a target. The model is then extended to touring finite numbers of targets and optimizing the routes. The model is found reliable through several simulations. Numerical experiments are conducted and we have shown that the UAV’s generated path satisfies vehicle dynamics constraints, tours the targets, and arrives at its destination.
Hyperbaric oxygen in children with cerebral palsy: A systematic review of effectiveness and safety
Authors: Laureau Justine , Pons Christelle , Letellier Guy , Gross Raphaël
Published: October 2022

Purpose

To report current evidence regarding the effectiveness of hyperbaric oxygen therapy (HBOT) on the impairments presented by children with cerebral palsy (CP), and its safety.

Materials and methods

PUBMED, The Cochrane Library, Google Scholar, and the Undersea and Hyperbaric Medical Society database were searched by two reviewers. Methodological quality was graded independently by 2 reviewers using the Physiotherapy Evidence Database assessment scale for randomized controlled trials (RCTs) and the modified Downs and Black (m-DB) evaluation tool for non RCTs. A meta-analysis was performed where applicable for RCTs.

Results

Five RCTs were identified. Four had a high level of evidence. Seven other studies were observational studies of low quality. All RCTs used 100% O2, 1.5 to 1.75 ATA, as the treatment intervention. Pressurized air was the control intervention in 3 RCTs, and physical therapy in 2. In all but one RCTs, similar improvements were observed regarding motor and/or cognitive functions, in the HBOT and control groups. Adverse events were mostly of mild severity, the most common being middle ear barotrauma (up to 50% of children).

Conclusion

There is high-level evidence that HBOT is ineffective in improving motor and cognitive functions, in children with CP. There is moderate-level evidence that HBOT is associated with a higher rate of adverse events than pressurized air in children.
COVID-19 messages in sponsored social media posts: The positive impact of influencer-brand fit and prior parasocial interaction
Authors: Buvár Ágnes , Szilágyi Sára Franciska , Balogh Eszter , Zsila Ágnes
Published: October 2022

This study explores the dissemination potential of a COVID-19 message embedded in a sponsored social media post. The moderating role of prior parasocial interaction and influencer-brand fit were considered. 365 respondents participated in the study. A 3 (control, congruent, incongruent brand) × 2 (control, COVID-19 message) between-subject online experiment was designed and executed. Data were analyzed using a mediated moderation model. Results indicated that the three-way interaction of the COVID-19 message, brand presence and prior parasocial interaction affected the perceived influencer credibility, attitudes towards the social media post, and the behavioral engagement with the post. When the COVID-19 message was included in the post, increased prior parasocial interaction intensified the positive effect of influencer-brand fit on influencer credibility, which in turn resulted in a more positive attitude towards the post, and a higher behavioral engagement. Theoretical and practical implications were discussed.
Reliability and clinical correlations of semi-quantitative lung ultrasound on BLUE points in COVID-19 mechanically ventilated patients: The ‘BLUE-LUSS’—A feasibility clinical study
Authors: Orosz Gábor , Gyombolai Pál , Tóth József T. , Szabó Marcell
Published: October 2022

Introduction

Bedside lung ultrasound has gained a key role in each segment of the treatment chain during the COVID-19 pandemic. During the diagnostic assessment of the critically ill patients in ICUs, it is highly important to maximize the amount and quality of gathered information while minimizing unnecessary interventions (e.g. moving/rotating the patient). Another major factor is to reduce the risk of infection and the workload of the staff.

Objectives

To serve these significant issues we constructed a feasibility study, in which we used a single-operator technique without moving the patient, only assessing the easily achievable lung regions at conventional BLUE points. We hypothesized that calculating this ‘BLUE lung ultrasound score’ (BLUE-LUSS) is a reasonable clinical tool. Furthermore, we used both longitudinal and transverse scans to measure their reliability and assessed the interobserver variability as well.

Methods

University Intensive Care Unit based, single-center, prospective, observational study was performed on 24 consecutive SARS-CoV2 RT-PCR positive, mechanically ventilated critically ill patients. Altogether 400 loops were recorded, rated and assessed off-line by 4 independent intensive care specialists (each 7+ years of LUS experience).

Results

Intraclass correlation values indicated good reliability for transversal and longitudinal qLUSS scores, while we detected excellent interrater agreement of both cLUSS calculation methods. All of our LUS scores correlated inversely and significantly to the P/F values. Best correlation was achieved in the case of longitudinal qLUSS (r = -0.55, p = 0.0119).

Conclusion

Summarized score of BLUE-LUSS can be an important, easy-to-perform adjunct tool for assessing and quantifying lung pathology in critically ill ventilated patients at bedside, especially for the P/F ratio. The best agreement for the P/F ratio can be achieved with the longitudinal scans. Regarding these findings, assessing BLUE-points can be extended with the BLUE-LUSS for daily routine using both transverse and longitudinal views.
SANReSP: A new Italian questionnaire to screen patients for obstructive sleep apnea
Authors: Romano Salvatore , Lo Bue Anna , Salvaggio Adriana , Oliveira Luis V. F. , Ferini-Strambi Luigi , Insalaco Giuseppe
Published: October 2022

Purpose

Obstructive sleep apnea (OSA) is a common, prevalent, and underdiagnosed disorder. Its lack of diagnosis and treatment is associated with increased morbidity and mortality. Previous screening questionnaires investigated parameters including body mass index, age, neck circumference, and sex, in addition to symptoms. This study aimed to validate a new Italian, self-administered, and easy-to-use six-item questionnaire that evaluates only subjective symptoms.

Patients and methods

The present study included 2622 patients (male, 2011; female, 611). Patients who were at least 18 years old, spoke Italian, referred to our sleep clinic for possible OSA, and completed the self-administered SANReSP questionnaire were recruited for the study. The predictive performance of the questionnaire was also evaluated.

Results

Nocturnal study showed 89.9% of OSA patients had apnea-hypopnea index (AHI) ≥ 5/h; 68.7%, AHI ≥ 15/h; and 48.2%, AHI ≥ 30/h. The optimal SANReSP score for AHI ≥ 5/h was >3 with a sensitivity and specificity of 74.76% and 67.92%, respectively, and an area under receiver operating characteristic curve (ROC) of 0.76. For moderate–severe OSA, the optimal SANReSP score was >3 (sensitivity, 78.18%; specificity, 46.53%; ROC, 0.66). For severe OSA, the optimal SANReSP score was >4 (sensitivity, 59.10%; specificity, 64.73%; ROC, 0.65). The probability of OSA increased with higher SANReSP scores (98.7% and 97.9% in men and women, respectively).

Conclusion

The SANReSP questionnaire is a short, easy-to-use, and self-administered screening tool for OSA. Its performance is similar to that of other widely used questionnaires; furthermore, it is advantageous in that it does not require anthropometric measurements.
Comparison of three-dimensional digital analyses and two-dimensional histomorphometric analyses of the bone-implant interface
Authors: Hong Jeong-Min , Kim Ung-Gyu , Yeo In-Sung Luke
Published: October 2022

Histological analysis is considered to be the gold standard method of evaluating osseointegration around a bone-implant. However, this method requires invasive specimen preparation and is capable of representing only one plane. By comparison, micro-computed tomography (μCT) is a fast and convenient method that offers three-dimensional information but is hampered by problems related to resolution and artifacts, making it a supplementary method for osseointegration analysis. To verify the reliability of μCT for osseointegration evaluation, this animal model study compared bone-to-implant contact (BIC) ratios obtained by the gold standard histomorphometric method with those obtained by the μCT method, using a rabbit tibia implant model. A sandblasted, large-grit, acid-etched (SLA) implant and a machined surface implant were inserted into each tibia of two rabbits (giving eight implants in total). Bone-implant specimens were analyzed using μCT with a spiral scan technique (SkyScan 1275) and histological sections were prepared thereafter. Three-dimensional (3D) reconstructed μCT data and four two-dimensional (2D) μCT sections, including one section corresponding to the histologic section and three additional sections rotated 45°, 90°, and 135°, were used to calculate the BIC ratio. The Pearson’s test was used for correlation analysis at a significance level of 0.05. The histomorphometric BIC and the 2D-μCT BIC showed strong correlation (r = 0.762, P = 0.046), whereas the histomorphometric BIC and 3D-μCT BIC did not (r = -0.375, P = 0.385). However, the mean BIC value of three or four 2D-μCT sections showed a strong correlation with the 3D-μCT BIC (three sections: r = 0.781, P = 0.038; four sections: r = 0.804, P = 0.029). The results of this animal model study indicate that μCT can be used to complement the histomorphometric method in bone-implant interface analyses. With the limitations of this study, 3D-μCT analysis may even have a superior aspect in that it eliminates random variables that arise as a consequence of the selected cutting direction.
Visualizing green capitalist renewable energy: Development and grassroots solar community alternatives in Puerto Rico
Authors: de Onís Catalina M. , Lloréns Hilda
Published: October 2022

Abstract

This article critiques industrial-scale solar energy development in Puerto Rico as a form of green capitalism that threatens the archipelago’s self-determination. Rather than uncritically embracing supposedly benign ‘green energy’ as necessary for advancing environmental, climate and energy justice, we argue that where, how and with whom this energy transformation takes place is crucial for calling attention to and challenging the continuance of inequitable and unjust power relations. To counter Puerto Rico’s ongoing exploitation as a ‘blank slate’ for development, we visually juxtapose the harms of industrial-scale solar ‘farms’ with distributed on-site, rooftop solar projects organized by grassroots group members in south-eastern Puerto Rico’s Jobos Bay region.
Seeing climate adaptation through an equity lens: Lessons learned from community adaptation to flood risk
Authors: Walker Sarah E. , Bailey Karen M. , Smith Elizabeth A.
Published: October 2022

In this article we describe the conceptual interactions between climate change adaptation and equity by analysing flooding adaptation strategies commonly used in the United States. We articulate the importance of an equity lens to support a more nuanced understanding of adaptation and inform adaptation strategy design that prioritizes equity as an outcome, rather than an externality. We include an illustration of what adaptation ‘looks’ like when applying an equity lens. We underscore the importance of such a lens for creating effective and just climate adaptation.
Calculation-experimental method for determining the prefailure state of complexly loaded journal bearings.
Authors:   South Ural State University, Chelyabinsk, Russian Federation, Nikitin D.N. , Zadorozhnaya E.A. ,   South Ural State University, Chelyabinsk, Russian Federation, Levanov I.G. ,   South Ural State University, Chelyabinsk, Russian Federation
Published: October 2022

The article deals with the types of wear and failures of journal bearings. Based on the physics of failures, a method for determining the pre-failure state of plain bearings is proposed, including: determination of the limiting clearance in the bearing; determination of the limit value of oil viscosity; determination of the limiting value of the ovality of the shaft neck and liners; determination of the maximum area of chipping of the surface of the liners; determination of the limit value of the concentration of active abrasive particles in the lubricant. The solution of these problems is based on the calculation of the determination of the hydromechanical characteristics (HMC) of bearings using the hydrodynamic theory of lubrication, the determination of the zones of contact interaction between the elements of the rolling stock, the duration of the boundary lubrication regime, the amount of wear on the surfaces of the sleeve and the shaft neck. Calculation studies were carried out on the example of calculating the dynamics of the connecting rod bearing of the crankshaft of a heat engine. In particular, it is shown that with a diametrical clearance in the connecting rod bearing of 90–120 μm, the duration of the boundary regime of lubrication is more than 25%, which is the limiting value. Reducing the oil viscosity (measured at 100 С) below 9.5 mPa∙s is unacceptable, as it leads to an increase in the duration of the boundary lubrication regime by up to 42%. For the same reasons, the ellipticity of the liners more than 5 microns is unacceptable. A mass concentration of active abrasive particles in the oil of more than 0.1% leads to a sharp increase in the maximum wear rate of the bearing, and this concentration should be considered the limit in terms of its pre-failure state. The technique allows at the early stages of designing machines, which include hydrodynamic plain bearings, to determine the criteria for their pre-failure state.