bluuebunny/crossref_metadata_2025 huggingface dataset:
Molecular genetic changes in gastric carcinoma
Authors: Singh Juhi , Kumar Puneet , Verma Khushi , Tiwary Satyender Kumar , Narayan Gopeshwar , Dixit V. K.
Published: November 2020

Gastric cancer remains highly prevalent and accounts for a notable proportion of global cancer mortality and this is associated with poor survival rates. Understanding the molecular genetic changes of gastric carcinoma may offer an insight into its pathogenesis helps in identifying new biomarkers, aid prognostication, and novel treatment targets. Over a past few decades, advances in technology and high throughput analysis have improved understanding of the molecular genetic aspects of gastric cancer. In this article, hierarchy of the changes at genetic and molecular level including several aspects which are heterogenous and represents a wide spectrum such as tumor suppressor genes, oncogenes, cellcycle regulators, apoptosis, cell-adhesion molecules, loss of heterozygosity, microsatellite instability, and epigenetic changes. The classification of gastric carcinoma at molecular and genetic level as well as hereditary gastric carcinoma is elaborated. The molecular genetic aspects regarding pathogenesis, changes and aberrations of all genes and pathways which are involved in gastric cancer are addressed in this review.
Granuloma faciale – A case report
Authors: Thomas Sumi
Published: November 2020

Granuloma faciale is a rare localized idiopathic inflammatory skin disorder that manifests as reddish-brown or violaceous papules, plaques, or nodules. It usually occurs in middle-aged adults and is rare in children. We are reporting a case of granuloma faciale in a 31-year-old male.
Neurocutaneous melanoma in association with giant congenital melanocytic nevi in a child (Touraine syndrome) – A dermatoradiological correlation
Authors: Puthiyakam Juvaina , Riyaz Najeeba , Arakkal Faiz Riyaz , Arakkal Riyaz
Published: November 2020

Touraine syndrome or neurocutaneous melanosis/melanoma is a rare melanophakomatosis characterized by extensive/multiple congenital melanocytic nevi associated with cerebral/meningeal melanosis or melanoma. We report a 12-year-old boy with a congenital giant melanocytic nevus on the bathing trunk distribution with scattered lesions on the face, neck, and legs. MRI brain revealed a melanoma in the right amygdala.
Aplikasi Bentonite Lokal Terhadap Nilai Compressive dan Shear Bond Strength Suspensi Semen Sumur Minyak
Authors: Khalid Idham , Musnal Ali , Novriansyah Adi , Sitanggang Kurniawan
Published: November 2020

[ID] Pelaksanaaan proses penyemenan yang baik pada sumur minyak merupakan aspek penting yang berpengaruh pada suskesnya produksi minyak ke permukaan. Untuk itu, penggunaan additif dalam suspense semen direkomendasikan supaya kulitas suspense semen tetap stabil selama proses penyemenan berlangsung. Melakui penelitian ini kualitas bentonite lokal dan bentonite komersial terhadap parameter compressive strength(CS) dan shear bond strength (SBS) akan dibandingkan. Pengukuran CS dan SBS dilkukan berdasarkan rekomendasi dari American Petroleum Institute (API) pada tujuh buah sampel suspense semen dengan konsentrasi aditif yang bervariasi.  Hasil penelitian terhadap bentonite lokal menunjukkan penurunan nilai CS dengan bertambahnya konsentrasi aditif. Konsentrasi optimum bentonite lokal adalah 1.6% dengan nilai CS sebesar 1649 psi, 6%  dibawah nilai CS untuk sampel suspense semen dan bentonite komersial pada konsentrasi yang sama. Untuk nilai SBS, konsentrasi optimum untuk aditif bentonite lokal adalah 4.8% dengan nilai SBS sebesar 439 psi, 21 % diatas nilai SBS untuk sampel semen dengan 4.8% bentonite komersial. Dari penentuan nilai CS dan SBS dapat disimpulkan bahwa penggunaan bentonite lokal dapat menjadi alternatif pengganti bentonite komersial dimana hasil pengukuran CS dan SBS tidak menunjukkan perbedaan yang signifikan.

[EN] The implementation of a good cementing process in oil wells is an important aspect that affects the success of oil production to the surface. For this reason, the use of additives in semen suspense is thought that the quality of the cement suspension remains stable during the cementing process. By doing this research, the quality of local bentonite and commercial bentonite against the parameters of compressive strength (CS) and shear bond strength (SBS) will be compared. CS and SBS measurements were carried out based on recommendations from the American Petroleum Institute (API) on seven cement suspension samples with varying additive concentrations. The results of research on local bentonite showed a decrease in the value of CS with an increase in additive concentration. The optimum concentration of local bentonite is 1.6% with a CS value of 1649 psi, 6% below the CS value for cement and commercial bentonite suspense samples at the same concentration. For the SBS value, the optimum concentration for local bentonite additives is 4.8% with an SBS value of 439 psi, 21% above the SBS value for cement samples with 4.8% commercial bentonite. From the determination of CS and SBS values, it can be shown that the use of local bentonite can be an alternative to commercial sites where the CS and SBS measurement results do not show a significant difference.
Evaluasi Kapasitas Elemen Struktur Eksisting Food Court Untuk Perencanaan Cinemaxx Mal Pekanbaru
Authors: Ardiansyah Rony
Published: November 2020

[ID] Evaluasi Kapasitas Struktur Eksisting Area Food Court seluas 1024m2 yang dialihfungsikan sebagai Cinemaxx. Penelitian ini dimaksudkan untuk mengetahui kapasitas izin dari elemen struktur eksisting pada elemen balok dan pelat lantai dengan memberikan beban hidup beragam. Struktur dimodelkan dengan menggunakan bantuan program ETABS 2015 untuk menganalisis gaya dalam pada elemen balok. Sedangkan untuk menganalisis gaya dalam pada elemen pelat menggunakan bantuan program SAP 2015. Adapun area yang ditinjau pada evaluasi ini yaitu pelat lantai-3 As-J s/d As-R dan As-2 s/d As-5. Hasil evaluasi menunjukkan bahwa pelat lantai eksisting pada bentang X dengan dan tanpa memperhitungkan defleksi balok, dinyatakan aman (OK) untuk beban hidup 400 & 500 kg/m2, untuk beban hidup 600 kg/m2 dinyatakan KRITIS dan untuk beban hidup 700 kg/m2 dinyatakan tidak aman (NO-OK). Pada pelat lantai, pelat bentang Y hanya beban hidup 400 kg/m2 yang dinyatakan aman (OK), beban hidup 500 kg/m2 dinyatakan KRITIS, dan beban hidup 600 kg/m2 dinyatakan tidak aman (NO-OK). Pelat lantai tanpa memperhitungkan pengaruh defleksi dari balok sekelilingnya atau dengan asumsi pelat sebagai beban, untuk semua beban hidup nya mulai dari 400, 500 dan 600 kg/m2 dinyatakan aman (OK). Momen lentur balok induk 350 x 650 pada tumpuan dinyatakan aman (OK) untuk semua beban hidup mulai dari 500 kg/m2 s/d 800 kg/m2. Sedangkan area lapangan dinyatakan (OK) untuk beban hidup 500 & 600 kg/m2; untuk beban hidup 700 kg/m2 dinyatakan tidak aman (NO-OK).

[EN] The evaluation of existing food court structural capacity with area size 1024m2 planned to be transformed to Cinemax. This research is purposed to determine permit capacity of existing structural elements on the beam and slab elements by providing various live loads. The structure is modeled using the ETABS 2015 program to analyze the internal forces on the beam elements. Then to analyze forces within slabs structures were modeled using the SAP 2015. The area covered in this evaluation is the floor slab-3 column centre J-R, and 2-5. The evaluation show for floor slab case in x-axis span, ignoring deflection of the beam, in response to 400 - 500 kg/m2 live load is considered to be safe (OK), 600 kg/m2 live load is considered to be critical, 700 kg/m2 live load is cosidered to be unsafe (NO-OK). In y-axis span, in response to 400 kg/m2 live load, it is considered safe (OK), 500 kg/m2 live load is considered critical, 600 kg/m2 live load is considered unsafe (NO-OK). All slabs assumed as its sole load without putting beam deflection into equation are considered safe in response to 500 - 600 kg/m2 live load. For main beams case (350x650), bending moment in support section is considered to be safe (OK) in all case of live load ranging from 500 - 800 kg/m2. While bending moment in midspan section, in response to 500-600 kg/m2 live load is considered to be safe (OK), 700 kg/m2 live load is considered to be unsafe (NO-OK).
Implementasi Promosi Kesehatan untuk Menurunkan Kasus Stunting di Wilayah Kerja Puskesmas Darajuanti Kabupaten Sintang
Authors: Komala Dewi Ria Risti , Putra Gandha Sunaryo
Published: November 2020

Abstrak: Puskesmas Dara Juanti menduduki peringkat pertama dengan kasus stunting tertinggi di Kecamatan Sintang dengan angka kejadian sebesar 26,62 % pada Tahun 2016, mengalami peningkatan sebesar 27,02% pada tahun 2017, dan pada tahun 2018 turun menjadi 22,79%. Walaupun kasus stunting mengalami penurunan, akan tetapi kasus stunting maksimal yang dipersyaratkan oleh World Health Organization (WHO) adalah 20%. Permasalahan yang terjadi di wilayah kerja Puskesmas Darajuanti yaitu belum dilakukannya program intervensi yang efektif terhadap kasus stunting khususnya peningkatan pemahaman akan pentingnya asupan gizi dan cara pengasuhan yang benar pada ibu yang memiliki balita.  Adapun solusi yang akan dilaksanakan dalam rangka penyelesaian masalah diatas adalah peningkatan pengetahuan melalui penyuluhan tentang gizi balita dan praktik pemberian makan pada balita di Wilayah Kerja Puskesmas Darajuanti. Tujuan dan target khusus yang ingin dicapai dari kegiatan ini adalah meningkatkan pengetahuan ibu balita tentang pentingnya asupan gizi dan cara pengasuhan yang benar pada balitanya serta peningkatan pengetahuan tentang bahaya stunting. Kegiatan dilaksanakan pada tanggal 12 September 2020 di posyandu Ulak Jaya. Metode pelaksanaan yang digunakan dalam pengabdian ini adalah sosialisasi, penyuluhan, dan pelatihan. Hasil kegiatan juga menunjukkan bahwa terdapat perbedaan yang bermakna tingkat pengetahuan responden sebelum dan sesudah dilaksanakan penyuluhan (p value=0,00).
MAKINA: hacia la utopía de un teatro-barco
Authors: Suarez Torrico Mauro Germán
Published: November 2020

Este artículo reúne el enfoque, el proceso, el proyecto y los resultados de un ejercicio circunscripto en el seminario “Théâtre en Utopie” de la Diplomatura en Escenografía en el DPEA, ENSA-Nantes, Francia, en el año 2018. Aquel abordó temas como la utopía y el teatro y trabajó la hipótesis de un teatro-barco navegable, como lo materializara alguna vez el Teatro del Mondo de Aldo Rossi en la Bienal de Venecia (1979). “No hay teatro sin utopía” (Freydefont, en Rocher, 2014, p. 11) así como no hay teatro sin aventura; por ello, analizaremos el viaje teatral extraordinario del proyecto Makina a través del río Sena.
La tecnología geoespacial como herramienta de planificación urbana utópica de la ciudad de Tlaxco, Tlaxcala, México
Authors: Montalvo Vargas Ramos , Gutiérrez Carreón Mayela Montserrat
Published: November 2020

El objetivo del presente trabajo es analizar las condiciones de planificación urbana en el municipio de Tlaxco, Tlaxcala. La metodología empleada se basó en técnicas de análisis espacial y los resultados muestran que el espacio urbano proyectado para el crecimiento de la ciudad era de 622,6 hectáreas y 1384 adicionales como zona de conservación y parque urbano; sin embargo, actualmente el amanzanamiento oficial cubre 1786,6 hectáreas; es decir, 1164 sin una regulación planificada. La ausencia de capacidades técnicas y conocimiento al interior de los gobiernos municipales, provoca que planificar sea una ilusión; y, hacerlo con tecnología geoespacial, una utopía.
Noroeste Urbanoide: identidad para un complejo ferroviário
Authors: Bispo de Souza Jadher Marcos
Published: November 2020

La urbanización de Campo Grande está vinculada a la llegada de los trenes, dando lugar a nuevos barrios y culturas que se mezclaban con aquella población ya existente. A mediados de la década de los 90 se produce la desactivación y retiro de los rieles de su red urbana y en este contexto los espacios ferroviarios y su historia fueron perdiendo su identidad. Como capital de un estado brasileño se podrían brindar alternativas al complejo con soluciones utópicas, emergiendo en proyectos del siglo xxi que podrían servir para el transporte público, y así generar un giro en la economía y el turismo. Se realiza un análisis crítico sobre la realidad encontrada y la evolución del espacio histórico y urbano de Mato Grosso del Sur.
Inteligencia artificial y/o el arquitecto
Authors: Chumpitaz Requena Favio
Published: November 2020

Los avances y el desarrollo de la tecnología en distintas herramientas, software y hardware, generan grandes implicancias en el proceso de la concepción del diseño arquitectónico. Dentro de ella, la inteligencia artificial puede marcar un punto de quiebre en la relación entre las máquinas y los arquitectos. Al brindarle a las máquinas una mayor capacidad de inteligencia, razonamiento y sensibilidad, los arquitectos podrán analizar con mayor profundidad un programa arquitectónico, pudiendo producir una gran cantidad de ideas y variables en las propuestas, tomando incluso distintos lenguajes arquitectónicos previamente aprendidos y modificando su propia labor en el proceso de diseño.
Exploración de la domótica emocional: una propuesta sensorial en la relación hombre-espacio
Authors: Silva Osores Carlos Eduardo , Carrión Puelles Naldi Susan
Published: November 2020

La arquitectura refleja la intencionalidad del diseñador por transformar el espacio y contribuir a la percepción de confort del usuario. En este proceso integra tecnologías de la información y comunicación —domótica— intensificando su interacción con diversos elementos del entorno. Su aplicación ha permitido hasta ahora la comunicación unidireccional del usuario con el espacio, pero al incorporar el reconocimiento inteligente de emociones se transforma en bidireccional posibilitando la respuesta del espacio, adaptándose. El presente artículo explora este cambio radical en la relación usuario-espacio y propone un modelo conceptual basado en el confort como punto de partida para profundizar en su estudio.
The minimum set, información, materia y significado
Authors: Briceño Gutiérrez Andrés
Published: November 2020

Si a la realidad primaria y perceptible de la materia se le da forma sustancial a través de la información a la que se ve sometida, ¿en qué dimensión la materia y la tectónica de la obra arquitectónica se someten a ser informadas a través de herramientas digitales? El dilema es comprender el tiempo que nos rodea, la constatación de que estamos en medio de un proceso de cambio no consolidado del modelo, donde la tecnología y el conocimiento que la genera está más cercanos a lo cotidiano conquistando un lugar habitual en nuestra sociedad, ergo, modificando variables del proyecto arquitectónico.
Hacia las intervenciones tecnológicas y sus implicancias sociales. Similitudes entre Chandigarh y Lima
Authors: Zadel Vanessa , Singh Mahavir , Kaushik Nishtha
Published: November 2020

Este artículo expone las posibilidades y el impacto social que las intervenciones tecnológicas tienen en nuestras ciudades. Las bases comunes de estas implicancias tecnológicas comprenden los campos; por ejemplo, soluciones IoT, inteligencia artificial, movilidad inteligente y soluciones integradas de gestión de residuos. Los fundamentos comunes del impacto social son una herramienta poderosa para la formación de comunidades inteligentes, que pueden demostrar equidad y accesibilidad. Por lo tanto, existe la necesidad de espacios para los creadores de la comunidad que puedan ayudar a otros no solo a mantenerse al día con la tecnología y usarla de manera eficiente, sino también para conectarlos con nuevas comunidades y adaptar diferentes soluciones a diversas condiciones físicas.
¿Cómo intervienen los usuarios en el espacio público?
Authors: Tornero Opfermann Rodrigo
Published: November 2020

El espacio público como área social, que invita a los usuarios al desarrollo de múltiples actividades, es también un territorio utópico de posibilidades donde se imaginan sueños y mejoras para la sociedad. La relación entre el espacio público y sus habitantes determina los factores que conducen a su transformación desde una base utópica. Dado que el espacio público de la ciudad informal no responde adecuadamente a las necesidades que la sociedad presenta, el diseño participativo consciente, que toma en cuenta la opinión e ideales de quienes utilizan el espacio, permite obtener un producto que satisfaga las exigencias de manera eficaz.
Evaluation of a voluntary augmented reality nutrition menu labelling application (Nutrilabelapps©) usage in a university café: a cross-sectional study in Terengganu, Malaysia
Authors: Zulkifli N.F.A , A. Asma' , Khairil-Shazmin K. , Zakaria N.S. , Mustafa M. , Mhd Jalil A.M.
Published: November 2020

Nutrilabelapps© is an interactive augmented reality mobile application (app) providing
nutrition menu labelling specifically built for Mutiara Café, a café in Universiti Malaysia
Terengganu. However, no evaluation of the usage of Nutrilabelapps© has been carried
out. Therefore, this cross-sectional study was aimed to determine the knowledge and
attitude of nutrition menu labelling among Mutiara Café customers; the feasibility and
acceptability of the app among customers; and also, the relationships between knowledge,
attitude, feasibility and acceptability of this augmented reality nutrition menu labelling
app. This study was conducted among 108 Mutiara Café customers who owned a
smartphone and were able to download the Nutrilabelapps©. The data were analyzed
using SPSS version 25. Findings showed that only 4.6% of Mutiara Café customers had
good knowledge of nutrition menu labelling, while 71.3% of them had a positive attitude
towards nutrition menu labelling. Nutrilabelapps© was accepted by users based on the
feasibility (67.6%) and acceptability (75.9%) of the app. Remarkably, there was a
significant association between knowledge, attitude, feasibility, and acceptability of the
app at p < 0.05. As a conclusion, Nutrilabelapps© is highly recommended among the café
customer despite their low knowledge of the nutrition menu labelling. Therefore, more
education of the public about nutrition menu labelling is highly recommended
Effect of emulsifiers on viscosity and emulsion stability of the cocoa powder mixture
Authors: Thuy N.M. , Ha H.T.N. , Tai N.V.
Published: November 2020

The study was initiated to generate data on the effectiveness of emulsifiers in the cocoa
mixture (use as a beverage) with the suitable cocoa butter content remaining in cocoa
powder. The experimental designs and comparative analyses will provide the information
and knowledge needed in using emulsifiers for improving cocoa powder dispersibility,
through viscosity and emulsion stability analysis. The present study was conducted to
improved cocoa powder mixtures which have good dispersibility in liquids. Emulsifier of
four types (polysorbate, sorbitan monostearate, lecithin from egg yolk/vegetable oil) with
the concentrations ranging from 0.25 to 0.7% on the viscosity and emulsion stability of
cocoa powder (16 and 20% of cocoa butter contents remained in cocoa powder) were
investigated. The obtained results showed that stabilizer levels markedly affected the
viscosity and emulsion stability of whipped mixture which increased with higher levels of
emulsifiers and cocoa butter contents. The dispersibility of cocoa powder can be
significantly increased by adding emulsifiers with the best results achieved at 0.572 and
0.668% of sorbitan monostearate and polysorbate, respectively, in comparison with
lecithin. The organoleptic evaluation on the cocoa powder samples also showed there
were significant differences (P0.05) in the sensory attributes of the product at this
concentration. This sample was adjudged the best based on the overall acceptance.
Nutrient content and shelf life analysis of freshwater snail (Pila ampullacea) instant baby porridge
Authors: Ihsani K. , Afifah D.N. , Anantyo D.T. , Mulyono  , Nugroho T.W. , Wahyudi F. , Nuryanto
Published: November 2020

The quality of instant baby porridge leads to nutrient content, consumer’s acceptability
and shelf life. The use of freshwater snail flour (Pila ampullacea) as a substitution in the
product increases the product nutrition value. The study analyzed nutrients content,
acceptability, and shelf life of instant baby porridge. An experimental study with a
completely randomized single factor design by using the three ratios of freshwater snail
flour KS 0 (0%), KS I (10%), and KS II (15%). The acceptability test (hedonic test) was
held on 25 semi-trained panelists and Arrhenius for shelf life analysis. Data were analyzed
using One-way ANOVA, Krusskal wallis test, and Mann-Whitney. The substitution of
freshwater snail flour could affect the nutrient content of carbohydrate, protein, fat, fiber,
water, ash, iron, zinc, and calcium (p<0.05). The substitution could affect the consumer’s
acceptance properties include color, flavor, texture, and taste (p<0.05). The shelf-life
testing for 15 days obtained results, KS 0 formula in temperature 35oC, 45oC and 50oC is
7.13; 2.13 and 2.16 months respectively. KS I Formula in temperature 35oC, 45oC and
50oC is 39, 40, 41 days. KS II Formula in temperature 35oC, 45oC and 50oC is 6 years 7
months, 6 years 8 months, and 6 years 9 months. Based on nutrient content analysis, the
substitution of freshwater snail flour could have enhanced protein, zinc, iron, calcium, and
fat. KS I, the best formula obtained has 20 g contribution in one serving, fulfilled the
energy adequacy of 14.41%, carbohydrates, 15.36%, protein 17.7%, fat 10.27%, fiber
1.7%, water 0.16%, iron 11.25%, zinc 10%, calcium 35.10% and the shelf life in
temperature of 35oC is 39 days, 45oC has a shelf life of 40 days and 50oC has a shelf life
of 41 days.
Nutrient content and physical properties of instant baby porridge substituted
with freshwater clams flour (Pilsbryoconcha exilis)
Authors: L.F. Fatma , Afifah D.N. , Anantyo D.T. , Mulyono  , Nugroho T.W. , Wahyudi F. , Nuryanto
Published: November 2020

Stunting is one of the nutritional problems with high frequency in Indonesia. One cause of
stunted children is the improper complementary feeding practice. A good quality diet
contains macronutrients (protein) and micronutrients (iron, zinc, and calcium) are linearly
correlated with children’s growth. A freshwater clam was a local food enriched with highprotein and zinc that is potential to be nutritional complementary foods. However, this
was substituted by full cream milk in instant baby porridge. The purpose of this study was
to analyze the effect of freshwater clams flour substitution on energy, protein, fat,
carbohydrate, fiber, zinc, calcium, and iron as well as physical properties (bulk density,
water absorption, and solubility) in instant baby porridge. The design of this study was a
single factor completely randomized design with the ratio of freshwater clams flour as
substituted in the instant baby porridge as 0% (F0), 5% (F1) and 10% (F2). There was also
an effect of substitution of freshwater clamss flour (Pilsbryoconcha exilis) on energy,
carbohydrate, protein, fat, moisture content, ash, crude fiber, calcium, iron, and zinc (p =
0.0001) in instant baby porridge. Variation in the percentage of freshwater clamss flour
substitution did not significantly influence the bulk density (p = 0.085), solubility (p
= 0,05) and water absorption (p = 0.341). Instant baby porridge F0 contained protein,
calcium, iron, and zinc less than the requirements. Instant baby porridge F1 had protein
and zinc less than the requirements, but calcium and iron levels met the requirements.
Meanwhile, the level of protein, iron, calcium and zinc on instant baby porridge F2 met
the requirements. Instant baby porridge with the substitution of freshwater clams flour
increased the nutrient content which includes protein, fiber, calcium, iron, and zinc but
decreased carbohydrate and fat content. Both formulations had a bulk density and
solubility which meet the requirement. However, water absorption did not meet the
requirements.
Tracing and preventing sharing and mutation
Authors: Giannini P , Servetto Marco , Zucca E
Published: November 2020

Copyright © 2019 for this paper by its authors. We present a type and effect system for tracing and preventing sharing and mutation in imperative languages. That is, on one hand, the type system traces sharing possibly introduced by the evaluation of an expression, so that uniqueness and immutability properties can be easily detected. On the other hand, sharing and mutation can be prevented by type qualifiers which forbid some actions. Sharing is directly represented at the syntactic level as a relation among free variables, thanks to the fact that in the underlying calculus memory is encoded in terms.
FHJ: A formal model for hierarchical dispatching and overriding
Authors: Wang Y , Zhang H , Oliveira BCDS , Servetto Marco
Published: November 2020

© Yanlin Wang, Haoyuan Zhang, Bruno C. d. S. Oliveira, and Marco Servetto. Multiple inheritance is a valuable feature for Object-Oriented Programming. However, it is also tricky to get right, as illustrated by the extensive literature on the topic. A key issue is the ambiguity arising from inheriting multiple parents, which can have conflicting methods. Numerous existing work provides solutions for conflicts which arise from diamond inheritance: i.e. conflicts that arise from implementations sharing a common ancestor. However, most mechanisms are inadequate to deal with unintentional method conflicts: conflicts which arise from two unrelated methods that happen to share the same name and signature. This paper presents a new model called Featherweight Hierarchical Java (FHJ) that deals with unintentional method conflicts. In our new model, which is partly inspired by C++, conflicting methods arising from unrelated methods can coexist in the same class, and hierarchical dispatching supports unambiguous lookups in the presence of such conflicting methods. To avoid ambiguity, hierarchical information is employed in method dispatching, which uses a combination of static and dynamic type information to choose the implementation of a method at run-time. Furthermore, unlike all existing inheritance models, our model supports hierarchical method overriding: that is, methods can be independently overridden along the multiple inheritance hierarchy. We give illustrative examples of our language and features and formalize FHJ as a minimal Featherweight-Java style calculus.
Flexible recovery of uniqueness and immutability
Authors: Giannini P , Servetto Marco , Zucca E , Cone J
Published: November 2020

© 2018 Elsevier B.V. We present an imperative object calculus where types are annotated with qualifiers for aliasing and mutation control. There are two key novelties with respect to similar proposals. First, the type system is very expressive. Notably, it adopts the recovery approach, that is, using the type context to justify strengthening types, greatly improving its power by permitting to recover uniqueness and immutability properties even in presence of other references. This is achieved by rules which restrict the use of such other references in the portion of code which is recovered. Second, execution is modeled by a non standard operational model, where properties of qualifiers can be directly expressed on source terms, rather than as invariants on an auxiliary structure which mimics physical memory. Formally, this is achieved by the block construct, introducing local variable declarations, which, when evaluated, play the role of store.
An Imperative Pure Calculus
Authors: Capriccioli A , Servetto Marco , Zucca E
Published: November 2020

© 2016 The Authors. Published by Elsevier B.V. We present a simple calculus where imperative features are modeled by just rewriting source code terms, rather than by modifying an auxiliary structure which mimics physical memory. Formally, this is achieved by the block construct, introducing local variable declarations, which also plays the role of store when such declarations have been evaluated. In this way, we obtain a language semantics which is more abstract, and directly represents at the syntactic level constraints on aliasing, allowing simpler reasoning about related properties. We illustrate this possibility by a simple extension of the standard type system which assigns a capsule tag to expressions that will reduce to (values representing) isolated portions of store.
Indicators of Elasticity of the Iliopsoas Muscle in Patients with Pain in the Lower Part of the Back due to the Manifestation of the Benign Joint Hypermobility Syndrome
Authors:   Ukrainian Medical Stomatological Academy, 23, Shevchenko St., Poltava 36011, Ukraine, Zhdan V. M. , Ivanitskiy I. V. , G. S. Khaimenova , Ischeikina Yu. A.
Published: November 2020

Pain in the lower back is a highly urgent problem that leads to a decrease in the quality of life of a large number of patients in the modern world. At the same time, the causes of pain in the lower back are different and their combination has not been sufficiently studied to date. It is known that the presence of benign joint hypermobility syndrome in a patient significantly worsens the course and manifestations of pain in the lower back. One of the components of pain in the lower back is changes in the iliopsoas muscle. This is psoas syndrome. At the same time, the diagnosis of psoas syndrome in practical medicine is complicated by the lack of specific laboratory tests and imaging techniques. The purpose of this work was to study the possibilities of determining the tension of the iliopsoas muscle using shear wave elastometry in patients with pain syndrome in the lower back and the difference between their tensions depending on the presence of benign hypermobility syndrome in patients. Material and methods. We examined 83 patients with lower back pain aged 42.31±1.54 years, 41 were female and 42 were male. To participate in the study, all patients underwent X-ray and ultrasound examination of the hip joints. Patients were excluded from the study in the presence of signs of osteoarthritis. To determine the presence of signs of hypermobility of the joints, we used the criteria of Baiton; the diagnosis was made on condition of obtaining more than 5 points. Among the patients examined by the Bayton criteria, 18 patients were diagnosed with benign joint hypermobility syndrome, among them 13 women and 5 men. As a control group, we selected 15 patients aged 45.6±1.74 years without complaints of pain in the lumbar region of the back and hips and without signs of benign joint hypermobility syndrome. We used shear wave elastometry to determine the stiffness of the distal parts of the lumbosacral muscle. A visual analog scale of pain (from 1 to 10) was used to determine the severity of the pain syndrome. Conclusion. We found that all patients with complaints of pain in the lower back had a significantly higher tension of the iliopsoas muscle in comparison with the group of conditionally healthy patients. The increase in tension had a strong correlation with the severity of pain syndrome according to the data of the visual analogue scale. Indicators of muscle tissue rigidity did not depend on the presence and severity of benign joint hypermobility syndrome
Analysis of Bioelectrical Brain Activity in Patients with Spontaneous Supratentorial Intracerebral Hemorrhage on the Ground of Conservative Therapy in Comparison with Disease Acute Period Functional Outcome
Authors:   Zaporizhzhia State Medical University, 26, Mayakovsky Avenue, Zaporizhzhia 69035, Ukraine, Kozyolkin O. A. , Kuznietsov A. A.
Published: November 2020

Despite significant advances in basic sciences and clinical neurology, acute cerebrovascular disorders continue to be a global problem in modern medicine, occupying a leading position in the structure of causes of death and disability in most countries. Hemorrhagic stroke and its most common form spontaneous supratentorial intracerebral hemorrhage is the most destructive type of cerebrovascular disorders, which is more likely to be fatal and severely disabled than ischemic stroke. The purpose of the study was to elaborate the criteria of spontaneous supratentorial intracerebral hemorrhage acute period functional outcome on the ground of analysis of bioelectrical brain activity during conservative therapy. Material and methods. We conducted a prospective cohort study of 114 patients (mean age 67.4±0.9 years) in acute period of spontaneous supratentorial intracerebral hemorrhage on the basis of conservative therapy. Clinical and neurovisual investigation helped to set the diagnosis. Bioelectrical brain activity examination was made on 1st-2nd day and 5th-6th days of the disease onset. Logistic regression and ROC-analysis were used for prognostic criteria elaboration. Results and discussion. Unfavorable functional outcome that was evaluated as modified Rankin scale score >3 on the 21st day of the disease was detected in 53 (46.5%) cases. These patients are characterized with double-side shift (with accentuation on the affected hemisphere) of spectral rhythm power towards the slow wave activity of predominantly delta band on first-second day and the following (on 5th-6th day) absolute spectral alpha rhythm power depression in intact hemisphere on 40.9% (р=0.0054). Declining of slow wave activity in intact hemisphere (ΔDAR=-51.7%, p=0.0002) was revealed in group of patients with favorable spontaneous supratentorial intracerebral hemorrhage outcome. Mathematic model for functional outcome prognosis was elaborated. It takes into consideration the values of DAR coefficient in affected hemisphere on first-second day (ОR (95% CI) = 2.03 (1.08-3.80), р=0.0276) and DAR in intact hemisphere on 5th-6th days from the onset (ОR (95% CI) = 5.84 (2.37-14.76), р=0.0001) (AUC (95% CI) = 0.97 (0.92- 0.99), р˂0.0001, prognostic accuracy = 88.6%). Conclusion. Bioelectrical brain activity reorganization on 5th-6th day from the spontaneous supratentorial intracerebral hemorrhage onset was associated with functional disease outcome. Thus, the criteria of unfavorable functional outcome are reduction of absolute spectral alpha rhythm power and ABR coefficient in intact hemisphere, while reduction of absolute spectral delta rhythm power, DTABR and DAR coefficients in intact hemisphere were associated with favorable functional outcome
The Investigation of the Dependence between Hand Eczema Severity and Some Cytokine Profile Parameters, Vitamin D Level, and Glucocorticoid Receptor Gene Polymorphism
Authors:   Sumy State Univercity, 2, Rymskogo-Korsakova St., Sumy 40007, Ukraine, Methkal A. M. , L. V. Kuts
Published: November 2020

Hand eczema is one of the most important chronic diseases in the dermatology. There are a lot of researches presenting the role of individual cytokines in eczema development. However, currently, the complex analysis of cytokines, hormones, and gene polymorphisms' impact on the development of hand eczema and its severity is absent. Therefore, the purpose of our work was to study the possible association between hand eczema severity and rs41423247 SNP, the blood level of IL-17A, IL-2, and 25(OH)2D3. Material and methods. The venous blood of 143 patients with hand eczema aged (42.2±11.1) years was used in the study. During the patients examination the data on age, sex, BMI kg/m2, BMI ≥25 kg/m2 (%), smoking, IgE (iu/ml), IL-17A (pg/ml), IL-2 (pg/ml), and 25(OH)2D3 (ng/ml) were obtained. The HECSI index (Hand Eczema Severity Index) was also assessed in each subject. According to HECSI value all patients were divided into three subgroups: mild, moderate and severe eczema. BclI SNP (rs41423247) of the glucocorticoid receptor gene (NR3C1) was determined using PCR-RFLP method. The statistical analysis was performed using the program SPSS 22.0. Results and discussion. The obtained results showed that the number of overweight people was higher among patients with severe hand eczema compared to patients with mild to moderate disease (P = 0.052). It was also revealed that the concentration of IL-17A in the blood serum of patients with severe hand eczema was significantly higher than in patients with mild to moderate disease (P = 0.037). The distribution of BclI polymorphism genotypes (NR3C1 gene), the blood level of IgE, IL-2, and 25(OH)2D3 were statistically equal between patients with different degrees of hand eczema severity (P > 0.05). Conclusion. Thus, the IL-17A serum concentration and body mass index are related to hand eczema severity. However, the link between NR3C1 gene BclI polymorphism, the blood level of IgE, IL-2, 25(OH)2D3, and hand eczema severity was not detected
COPD and Kidneys: Two Sides of the One Problem
Authors:   Kharkiv National Medical University, 4, Nauky Avenue, Kharkiv 61022, Ukraine, Ospanova T. S. , Semydotska Zh. D. , Cherniakova I. O. , Pionova O. M. , Tryfonova N. S. , Avdieieva O. V.
Published: November 2020

The problems of diagnosis, treatment, prevention of chronic obstructive pulmonary disease remain relevant due to the increase in morbidity, disability and mortality of patients. Recently, the level of renal dysfunction in the progression of chronic obstructive pulmonary disease has increased. The purpose of research was to study the indicators of renal dysfunction in chronic obstructive pulmonary disease, depending on the severity and frequency of chronic obstructive pulmonary disease exacerbations, comorbidity, respiratory function, morphological and functional state of the myocardium to optimize the diagnosis and prognosis of chronic obstructive pulmonary disease. Material and methods. The article presents the results of examination of 81 patients in different groups of chronic obstructive pulmonary disease (BCD) with comorbidity (arterial hypertension in 49 patients, diabetes mellitus type 2 – in 16, postinfarction cardiosclerosis – in 6, diffuse cardiosclerosis – in 53, angina pectoris – in 5 patients). The external respiration function was made by using a computer spirograph. The morphological and functional state of the myocardium was studied by the standard ultrasound examination. Glomerular filtration rate was estimated by using the Cockcroft-Gault formula. The A/C ratio, microalbuminuria in the morning urine portion, and the level of C-reactive protein were also studied. The results of the studies were analyzed by methods of nonparametric statistics with an assessment of differences between groups of patients using the Mann-Whitney U-test; to assess the parameters of the relationship between indicators, the method of pair rank correlation by Spearman was used. Results and discussion. Signs of renal dysfunction, hypoxia (SpO2), systemic inflammation of low intensity C-reactive protein were found only in group D of patients with chronic obstructive pulmonary disease. In the same group, the greatest number of correlations of indicators of renal dysfunction and SpO2 with various indicators of the morphofunctional state of the myocardium according to echocardiography, the frequency of exacerbations, and comorbidity with hypertension, diffuse and postinfarction cardiosclerosis was revealed. In group B and C, no correlations of indicators of renal dysfunction with other indicators were found. In the group of patients with GFR less than 90 ml/min/1.73m2, there were correlations of the A/C ratio with the frequency of exacerbations, C-reactive protein, correlations between microalbuminuria and dyspnea, daily proteinuria, and SPPA. Conclusion. In the future, it is necessary to continue the search for early specific available biomarkers of renal dysfunction that can be used for early prescription of pleiotropic therapy, and timely initiation of nephroprotection from the standpoint of network medicine
Pathogenetic Changes in the Expression of Apoptotic Marker Caspase-3 in Patients with Type IІ Diabetes Mellitus and Excess Body Weight and Obesity
Authors:   Zaporizhzhya Medical Academy of Postgraduate Education of Health Ministry of Ukraine, 20, Vinter Boulevard, Zaporizhia 69041, Ukraine, Solovyuk A. A.
Published: November 2020

The determination of molecular mechanisms, genetic control pathways, and modeling of apoptotic processes are necessary for understanding the pathogenesis of type 2 diabetes mellitus, especially in combination with obesity and excess body weight, which in the future may create prerequisites for the search for pathogenetic treatment. The purpose of the study was to assess the state of apoptosis processes in patients with type 2 diabetes mellitus in combination with excess body weight and obesity, depending on the clinical characteristics of the disease. Material and methods. 98 people with diabetes mellitus were examined. The first group consisted of 64 people with excess body weight and obesity (body mass index >25). The second group included 34 people with type 2 diabetes mellitus and normal body weight (body mass index ≤25). The control group consisted of 28 practically healthy individuals, who were comparable to the first and second groups by gender and age. Results and discussion. The presence of type 2 diabetes mellitus, excess body weight and obesity in patients led to increasing the level of the marker of apoptotic death of body cells – caspase-3 by 16.52%. Patients with glycated hemoglobin HbA1c more than 8% showed an increase in caspase-3 compared with patients with compensated diabetes mellitus; the difference was more pronounced in patients with excess body weight and obesity (19.13%, p <0.05). An increase in the duration of type 2 diabetes mellitus led to the activation of apoptosis processes, which was manifested in the rise of the studied apoptosis marker, caspase-3, both in patients with and without obesity (p <0.05). The development of the complication of type 2 diabetes mellitus in obese patients increased caspase-3 levels by 29.04% (p <0.05) in the absence of significant changes in this marker in patients with type 2 diabetes mellitus without obesity. Conclusion. The dynamics of apoptotic processes in patients with type 2 diabetes mellitus combined with and obesity, depending on the clinical characteristics of patients, is closely related to the level of apoptosis marker – caspase of the cysteine proteinase group – caspase-3
Status of Professional Morbidity in the Pridneprovsk Economic Region during 2015-2019
Authors:   Ukrainian Research Institute of Industrial Medicine, Vinogradov Street 40, Kryvyi Rih 50096, Ukraine, Ivchuk V. V.
Published: November 2020

The purpose of the study was to analyze the occupational morbidity in the Dnieper Economic Region, its structure in dynamics for 2015-2019, identify the main causes that lead to the formation of occupational pathology, and suggest ways to solve the problem. Material and methods. Based on the processing of the medical documentation of the clinic, the Ukrainian Research Institute of Industrial Medicine, we conducted a comparative analysis of occupational morbidity indicators in the dynamics of 2015-2019 was carried out taking into account the main forms of pathology and regional distribution. Results and discussion. The level of occupational morbidity among workers of the Dnieper Economic Region in 2015-2019 varies from 354 to 10307 cases. The leadership in the formation of professional pathology remains with the Dnipropetrovsk region, where large enterprises of the leading branches of heavy industry are located, in dangerous and harmful conditions of which a significant number of people work. In the structure of occupational morbidity, the first place is occupied by chronic obstructive pulmonary diseases of occupational etiology (31.7%), the second is cochlear neuritis (27.3%), the third is radiculopathy (23.7%), and the fourth is vibration disease (7.6%). Indicators of occupational morbidity indicate only the detection of occupational pathology. The statistics do not reflect the true situation, which is due to the imperfection of labor protection legislation, the lack of legal and economic sanctions for concealing occupational diseases, and the shortcomings of medical diagnostic and preventive work among workers. The solution to this problem, in our opinion, may consist in enhancing coordination of the entire complex of scientific and practical activities for the development and substantiation of strategies, tactics and implementation of national policies from the most important areas of occupational medicine. Conclusion. It is necessary to formulate a systematic approach to the prevention of occupational morbidity of the population, taking into account the characteristics of the current situation in the region and in the country as a whole. Comprehensive solution of problems in the health of workers, taking into account the interagency coordination of the system of measures, in the future will ensure the preservation of labor potential, prolong working life, and reduce general and occupational diseases
Control Logistics in a Modern Medical Institution: the Main Organization Mechanisms
Authors:   MEDSERVICE GROUP LTD, 52, Degtyarivska St., Kyiv 04112, Ukraine, Kolomoets A. V. , Mikhalchuk V. M. ,   Shupyk National Medical Academy of Postgraduate Education, 9, Dorohozhytska St., Kyiv 04112, Ukraine, Tolstanov O. K. ,   Shupyk National Medical Academy of Postgraduate Education, 9, Dorohozhytska St., Kyiv 04112, Ukraine, Gbur Z. V. ,   Shupyk National Medical Academy of Postgraduate Education, 9, Dorohozhytska St., Kyiv 04112, Ukraine
Published: November 2020

In the logistics approach, the health care organization is seen as a system that incorporates many interconnected processes, the ultimate goal of which is to provide quality health services. Modern system and process approaches to management have also undergone significant changes in the management of medical institutions, applying new methods and technologies of resource management, which are based on the concept of logistics. The positive aspects of logistics technologies in health care institutions are the following: the ability to influence the strategy and tactics of health care institutions, the formation of new competitive market advantages in this market segment. The use of logistics methods and technologies optimizes the processes of information input on the amount of resources consumed, its receipt and transmission of information, thus improving the quality of medical care. The main idea of the logistics process is to create a certain result from the resources available in medical institutions. It should be noted that today companies in various sectors of the economy are interested in the transition to logistics management. The advantage of the logistical approach in health care is the ability to influence the strategy and tactics of the medical organization, to create new competitive advantages in the market of medical services. The use of logistics accelerates the process of obtaining and transmitting information about the necessary resources as a result, improving the quality of medical services. In this way, logistics coordinates the resource provision of the health care organization as a whole. Conclusion. Implementation and use of the world best practices of the logistics concept "just in time" to optimize the needs and time of supply of medical devices of each structural unit of the medical institution will ensure continuity of processes in the health care facility as medical supplies and property arrive on time, and , at the same time do not accumulate in warehouses unclaimed (which, in turn, reduces the turnover of working capital and as a result negatively affects the financial stability of the organization), which contributes to the rapid restructuring of the supply system to the needs of health care