bluuebunny/crossref_metadata_2025 huggingface dataset:
Altered serum TNF-α and MCP-4 levels are associated with the pathophysiology of major depressive disorder: A case-control study results
Authors: Nayem Jannatul , Sarker Rapty , Roknuzzaman A. S. M. , Qusar M. M. A. Shalahuddin , Raihan Sheikh Zahir , Islam Md. Rabiul , Mahmud Zobaer Al
Published: November 2023

Background

Major Depressive Disorder (MDD) is a debilitating mental health condition with complex etiology, and recent research has focused on pro-inflammatory cytokines and chemokines as potential contributors to its pathogenesis. However, studies investigating the roles of TNF-α and MCP-4 in MDD within the Bangladeshi population are scarce. This study aimed to assess the association between serum TNF-α and MCP-4 levels and the severity of MDD, exploring their potential as risk indicators for MDD development.

Methods

This case-control study enrolled 58 MDD patients from Bangabandhu Sheikh Mujib Medical University (BSMMU) Hospital, Dhaka, Bangladesh, alongside 30 age, sex, and BMI-matched healthy controls. MDD diagnosis followed DSM-5 criteria and disease severity using the 17-item Hamilton Depression Rating Scale (Ham-D). We measured serum TNF-α and MCP-4 levels using ELISA assays according to the supplied protocols.

Results

The study revealed significantly elevated serum TNF-α levels in MDD patients (47±6.6 pg/ml, mean±SEM) compared to controls (28.06±1.07 pg/ml). These increased TNF-α levels positively correlated with Ham-D scores (Pearson’s r = 0.300, p = 0.038), suggesting a potential association between peripheral TNF-α levels and MDD pathology. Additionally, MDD patients exhibited significantly higher serum MCP-4 levels (70.49±6.45 pg/ml) than controls (40.21±4.08 pg/ml). However, serum MCP-4 levels showed a significant negative correlation (r = -0.270, P = 0.048) with Ham-D scores in MDD patients, indicating a more complex role for MCP-4 in MDD pathogenesis.

Conclusion

This study highlights that Bangladeshi MDD patients exhibit heightened inflammatory and immune responses compared to controls, supporting the cytokine hypothesis in MDD pathogenesis. Serum TNF-α, but not MCP-4, shows promise as a potential biomarker for assessing the risk of MDD development, which could aid in early detection. Future investigations involving larger populations and longitudinal studies are essential to confirm the utility of these cytokines as biomarkers for MDD.
Prolonged and Recurrent Intrahepatic Cholestasis of Pregnancy
Authors: Kaviani Rojin , Chahal Daljeet , Chung Michelle Ho , Yoshida Eric M.
Published: November 2023

Intrahepatic cholestasis of pregnancy is one of the most common disorders of pregnancy, which typically resolves in the postpartum period. Intrahepatic cholestasis is characterized by elevated bile acid levels that present as pruritus. The maternal clinical significance of recurrent and prolonged cholestasis is unknown. We discuss the longest reported case of postpartum cholestasis of 125 weeks.
Virtualidad y pandemia: representaciones y estrategias identitaria
Authors: Lewin Gabriel Gustavo
Published: November 2023

Durante la actual situación sanitaria, las medidas preventivas han acelerado en forma inédita la denominada virtualización; por lo que amerita detenerse en el debate sobre los procesos de virtualización forzada,vincularidad virtual y representación de identidades en redes y espacios digitales, estudiados mediante diversas denominaciones: migración identitaria, virtualización, ciborgización, avatarización. En estos procesos de virtualización el cuerpo se ve expuesto a una nueva modalidad de “protesización”. Como borde permeable, desde una posición de cognición situada deriva hacia identidades distribuidas (fluidas, nómades, mutantes); expandiendo las funciones y capacidades de nuestroorganismo hacia nuevas proyecciones tanto representativas como comunicativas. (Radrigán Brante,2015). Abordaremos los aportes de Haraway, Aguilar y otres, que apuestan a recorrer crítica y productivamente esas tensiones, para indagar desde las alteridades el vínculo con las tecnologías digitales, que nos permitirán considerar la corporalidad como anclaje y eje pivotante de todo el proceso.
El cuerpo de la educación: entre el individualismo y el reconocimiento. Un estado de la cuestión
Authors: Rodríguez Silva Laura Angélica
Published: November 2023

En el marco de la investigación doctoral sobre prácticas de creación colectiva y su aporte a procesos pedagógicos que hacen énfasis en los vínculos humanos, el artículo presenta la indagación en torno a las relaciones entre cuerpo y educación, con miras a identificar tendencias que permitan un estado de la cuestión. Como resultado, se encuentran, principalmente, dos tendencias, una en la que prima el individualismo, desde una revisión de la escuela como institución; y otra, en la que se abren las posibilidades para el reconocimiento y la alteridad.
Las revistas españolas de cirugía, de la miscelánea al formato electrónico
Authors: Estrada-Lorenzo José Manuel , Medino-Muñoz Juan A. , Ferrero Herrero Eduardo
Published: November 2023

El conocimiento y la investigación quirúrgicos, como en el resto de ciencias, se transmitió hasta el siglo XVII a través de libros, pero es en la revista científica, donde encuentra su medio natural de difusión y comunicación entre expertos. En España el desarrollo de la cirugía llegó más tarde, hay que esperar hasta el siglo XVIII, de igual manera las publicaciones periódicas sobre la materia, en un principio más en formato miscelánea y alejadas todavía de lo que concebimos hoy como publicaciones científicas, para lo que habrá que esperar a la segunda década del siglo XIX. El período de máxima eclosión de publicaciones sobre cirugía se produce en la primera mitad del siglo XX. En la actualidad se identifican cuatro revistas quirúrgicas de temática general, consolidadas y presentes en los índices de impacto internacionales y comprometidas con el acceso abierto. En paralelo, a lo largo del siglo XX fueron apareciendo revistas de especialidades quirúrgicas (cardiovascular, oral, ortopédica, plástica, pediátrica, neuroquirúrgica…).
The Assessment of the General Health Status of the Sarajevo Canton Residents Through General Biochemical Testing Results
Authors: Ramic Faris
Published: November 2023

In this research, we will be assessing the general health status of the Sarajevo Canton residents by analyzing the biochemical test results for the samples from the study cohort collected in 2021 for the following testing panels: lipid panel, liver panel, thyroid panel, electrolyte panel, and prostate panel. Along with the biochemical components that are tested, their physiological importance and consequences of deregulation, we are introducing the reasons for ordering the tests, as well as potential findings and conclusions from the testing results. Devices that were used for this research are Gesan Chem 200 (Gesan Production, Campobello di Mazara, Italy) and Architect 1000 (Abbot, Chicago, IL), both operated according to manufacturer’s instructions. The collection of demographic data and test results was performed through usage of Laboratory Information System (LIS). Test results of the study participants were compared with referent values, as provided for the population average. Initial results were summarized and compared through descriptive statistics, while the exact test of goodness-of-fit was used to assess the compliance of observed data with expected referent values. Demographic trends, in terms of which sex and/or age group are more likely to have any tested parameter deregulated, either increased or decreased, are presented and discussed in detail. Finally, recommendations for future testing and prophylaxis are given.
Hydrophobic Interaction Chromatography: A Key Method for Protein Separation
Authors: Kovacevic Nermana , Tariq AL-Boush Mohammad
Published: November 2023

This review's main goal is to increase theoretical knowledge and comprehension of the techniques used to separate important enzymes using chromatography. Protein separation, purification, and analysis frequently involve the use of hydrophobic interaction chromatography (HIC), in which the molecules are separated based on differences in hydrophobicity. It is conducted using a weakly hydrophobic, nonpolar stationary phase to which the proteins bind in an aqueous highsalt solution as the mobile phase. The protein integrity is thereby conserved during the process. HIC is usually used with a gradient from high to low concentrations of salt as an eluent and can be applied in a wide range of biotechnological processes. In this study, after a brief overview of hydrophobic interaction chromatography, we explain the HIC procedure, protein retention mechanism, factors affecting HIC, and applications of HIC.
Solar Irradiation Prediction Based on M5 Model Tree and Feature Importance Evaluation
Authors: Idrizovic Lejla , Lulic Skopljak Lejla , Haznadarevic Faris , Ahmetovic Haris
Published: November 2023

In the last decade, the usage of renewable energy is on the rise, and that trend will only continue because technology is becoming more developed, so renewable energy sources are going to offer more for the same price. Besides all positive properties, there are also some negatives like direct dependence on the weather conditions. That means energy production is constantly changing, so it must be as precisely as possible predicted to be usable on a large scale. Fifteen attributes were analyzed using M5 regression tree. High positive degree of correlation was found between participle water and dew point temperature, air temperature with dew point, air temperature with precipitation of water, snow depth with Albedo daily, zenith angle with relative humidity, GHI with Air temperature. It was found that the zenith angle, between the normal of the Earth’s surface and the Sun, was the most important feature of the dataset for solar irradiation prediction.
Letter Recognition Using Machine Learning Algorithms
Authors: Ceranic Merima , Jukic Samed
Published: November 2023

Optical character recognition represents the mechanical or electronic conversion of handwritten, typed or printed images into coded text. Optical character recognition is widely used as a form of data entry from records that have been printed, and it can include invoices, bank statements, passports and many more. In the research, Optical character recognition reads data from the Re-Captcha dataset of images, converts them into strings, and these strings are used for testing, training and calculating prediction accuracy. The methodologies used are Convolutional neural network and Recurrent neural network. The convolutional neural network consist of neurons that receive data and group them according to similarity. A recurrent neural network cycle can be created between the connections of nodes, allowing the output from nodes to influence the subsequent input to other nodes. For data were used Re-Captcha images, and for the prediction of characters from images was used TensorFlow with Keras. The best results that are produced can be compared between first and last result, where the loss for first result was 20.63 and value loss was 16.45, while last result has loss of 0.56 and value loss of 2.96
From the Past to the Future: a Milestone of Muban Chombueng Rajabhat University in Sustainable University
Authors: Siladech Chairit , Kongtoom Rapeepan , Rattananon Eaimrit , Chuenjit Atima
Published: November 2023

This paper presents a milestone of Muban Chombueng Rajabhat University in sustainability. The university was founded in 1954 with the concept of Village College. The purposes of the establishment were to provide educational opportunities for students and to solve the lack of teachers in distant areas around Thailand. The college trained teachers and practiced some skills to be community developers. Nowadays, the university is still on the pathway of sustainability. The university provides educational opportunities for all through degree programmes. Furthermore, the university has promoted the MCRU Credit Bank System for lifelong learning so that people of every background can participate in classes. As part of the community, the university cooperates with local communities to improve the quality of life and increase household income. For research and innovation, the university encourages academia and students to create projects focused on solving community problems. These projects impact society in all aspects, especially, good health and well-being. For the future, the university announces a five-year plan to demonstrate the direction of a sustainable university. The university improves curricula based on social dynamics and trains students to be global citizens. However, the decrease in new enrolment will be a new challenge. It affects the university's income also decreases. Therefore, it challenges the allocation budget to develop students and provide outreach projects. Moreover, the local communities also face the aged society, and this new challenge should be aware from all institutions. From this condition, the university is the partnership with communities to tackle these challenges and settle sustainability.
Scaling-Down Teaching and Research Indicators is Crucial to Define the Holistic Performance of Universities
Authors: Regueira Rubén , Feijoo Gumersindo
Published: November 2023

This article proposes a two-dimensional model that allows for the evaluation of teaching and research based on quantitative indicators. Regarding teaching performance, the hours of face-to-face classes and those of supervised theses were considered. In the case of research activity, several indicators were proposed (e.g. books and book chapters, articles in JCR journals, patents and translations), which allow for the application to multiple academic disciplines in the fields of Arts & Humanities, Science, Engineering, Health Sciences and Social & Legal Sciences.  Our model has been applied to 119 academic disciplines in the 2010s and the results obtained were analyzed under various perspectives: (i) performance timeline, (ii) comparative analysis among different academic disciplines, (iii) scale-down of the analysis to diverse units (e.g. departments, research groups), as well as to the quantification of the individual effort of each faculty member, and (iv) gender perspective. As a model use case, the Department of Chemical Engineering at the University of Santiago de Compostela (USC) was studied. One of the key takeaways of this analysis was that understanding teaching and research reference levels is crucial in defining university-specific targets, both individually and collectively. In fact, this is even more relevant for less hierarchical and more assembly-based academic institutions, where it is difficult to define a minimum standard of research activity.
Beyond Rankings: UI GreenMetric Network Online Courses on Sustainability
Authors: Junaidi Junaidi , Sari Riri Fitri , Ramadianti Sabrina Hikmah , Sidiyanto Yogi Andrian
Published: November 2023

UI GreenMetric World University Rankings is the first sustainability ranking recognizing universities that prioritize sustainability in their programs. It extends into a network of universities conducting global activities for knowledge sharing. To further its goal of creating global sustainability leaders, UI GreenMetric offers an online course on sustainability since 2020. Managed by international and Indonesian groups, the course focuses on international student collaboration to learn about intricate relationships between the economy, social life, and the environment, and the effects of human activities on the planet with solutions to address them. The UI GreenMetric Online Course on Sustainability utilizes synchronous and asynchronous learning systems and enables students to develop project proposals related to SDGs. The course evaluation indicates a high level of student engagement and utilization of the Moodle platform. The assessment instruments, including quizzes, question forums, and project reports, received positive feedback and were effective in supporting student learning. Collaborative group work and exposure to multicultural perspectives enriched the learning experience. While the adequacy of weekly materials was generally acknowledged, some participants suggested areas for improvement. Lessons learned from the course include acquiring SDGs knowledge, the diverse perspectives gained from professors and students, and establishing international networks. The findings underscore the significance of collaboration and identify opportunities for further enhancement in future iterations of the course.
Carbon Footprint of Universitas Airlangga Before and During the Covid-19 Pandemic
Authors: Hajjarianti Permata , Fitriani Nurina , Zagita Lauditta Chavia , Ana Devi , Widyaleksono Trisnadi , Soegianto Agoes , Dianbudiyanto Wahid , Karnaji Karnaji , Miftahussurur Muhammad
Published: November 2023

This study focus on calculating the carbon footprint from the activities of the Universitas Airlangga. CO2 emission calculations were carried out using the UI GreenMetric method and the Intergovernmental Panel on Climate Change (IPCC) in two periods: before the Covid-19 pandemic and during the Covid-19 pandemic. Activities at Universitas Airlangga that produce carbon footprints are divided into two main sources, first, primary sources that come from direct combustion of fuel into energy, such as burning fuel in motorized vehicles and a secondary source that comes from an indirect source of using electricity in the campus area. The results showed that in the period before the pandemic, the total carbon emissions, based on the IPCC calculation method, were 23.830,34 tons of CO2-eq/year. Meanwhile, based on the UI GreenMetric method, a total carbon emission of 26.325,36 tons of CO2-eq/year was obtained. As for the time period during the pandemic, Universitas Airlangga's total carbon emissions obtained based on the IPCC calculation method were 20.506,69 tons of CO2-eq/year. Meanwhile, based on the UI GreenMetric method, a total carbon emission of 22.321,63 tons of CO2-eq/year was obtained. Secondary carbon footprint mapping is carried out to ascertain the distribution of secondary CO2 emissions produced by Universitas Airlangga. The secondary carbon footprint both before and during the Covid-19 pandemic was mostly generated by the Universitas Airlangga Hospital.
Seminars In Education for Sustainability Aimed at Basic Education Teachers, as a Community Service Involving Postgraduate Students
Authors: Rangel José Alí Moncada , Hernández Lucía Del Rocío Vásquez , Pulles Segundo Hernán Cadena
Published: November 2023

The teaching profession as a decisive role in the construction of sustainability as a civilizing model. The present community service project aims to implement a teacher training and updating process on sustainability issues and teaching tools for environmental education aimed at Basic Education teachers. The methodology was structured in two stages: 1.- Development of the teaching training and updating process, considering institutional needs and emerging disciplinary themes; 2.- Process evaluation. The seminar was developed with the participation of 112 teachers from different educational units in the Province and included conferences on Education for the SDGs, Education for the conservation of biodiversity and climate change, Education for responsible consumption and Horizontal Education. For their part, postgraduate students developed six workshops on didactic strategies such as simulation, comic strips, bulletin board, creation of terrariums, role playing and asking game. The evaluation applied after the seminar showed high acceptance of the activities carried out by trained teachers and postgraduate students. In the next training sessions, postgraduate students are expected to go to the educational communities of the schools to contextualize the training. Finally, the strategy made it possible to strengthen university community services that promote sustainability
Increasing The Awareness of Students at Montenegrin Universities About the Importance of Sustainable Development
Authors: Jankovic Marija
Published: November 2023

Today's ecological problems that threaten life on the planet, including global warming, loss of biodiversity, plastic pollution of seas and oceans, are largely unrecognized by individuals and communities. In this sense, scientific institutions should play a key role in developing awareness in the community, especially among students, about the consequences of pollution, the costs of pollution, in such a way as to adopt and promote "green" development policies. Today's "green" universities recognize the importance of this important global topic and develop questions about sustainable development through their studies and extracurricular activities, promote sustainability topics through marketing activities, adopting the very concept of sustainable development in continuity. Courses focused on "green" issues are introduced through the academic curricula. This paper aims to examine the level of awareness of university students in Montenegro about the implementation and level of adoption of "green" policy in university practices and offer ways to improve this concept. The work will represent a good basis for the improvement and adoption of the concept of "green" development at Montenegrin universities.
How Tax Credit Shapes Firm R&D Strategies?
Authors: Courtioux Pierre , Metivier François , Reberioux Antoine
Published: November 2023

This study extends the definition of firms’ R&D strategies to integrate fiscal considerations related to R&D tax credits. Using French company data, we identify six types of ‘extended’ R&D strategies. We then examine the relationships of these strategies with the effective rate of R&D tax credits, defined as the ratio of total tax reliefs obtained by a firm through R&D tax credit to real R&D spending. This study contributes to a better understanding of the heterogeneity of companies’ R&D strategies.
MicroRNA-29a and microRNA-122 expressions and other inflammatory markers among obese children with diabetes
Authors: Bayoumy Nervana M.K. , El-Shabrawi Mohamed M. , Elsayed Wafaa , Kamal Hagar A. , abdelmaogood Asmaa K. , Ahmed-Maher Shymaa , Omar Hamdy H. , Abdel-Rahman Ahmed
Published: November 2023

Objectives

This study was conducted to study the expression of both microRNA-29a and microRNA-122, and serum levels of sestrin-2, interleukin-6 (IL-6), and other inflammatory markers among obese children with/and without diabetes mellitus.

Methods

One hundred obese children with diabetes in addition to 100 age- and sex-matched obese children without diabetes, and 100 age- and sex-matched apparently healthy children were included in the study. Expressions of both microRNA-29a and microRNA-122, and serum levels of sestrin-2, IL-6, tumor necrosis factor-α (TNF-α), and high sensitive-CRP (hsCRP) were measured for all included study populations.

Results

Study results showed that the expressions of both microRNA-29a and microRNA-122, serum levels of IL-6, TNF-α, and hsCRP were significantly higher among obese children with diabetes in comparison to both obese children without diabetes and healthy children. In contrast, serum sestrin level was significantly low among obese children with diabetes in comparison to the other study populations. Expressions of both microRNA-29a and microRNA-122 were correlated with waist circumference, BMI, total cholesterol, triglycerides, LDL-cholesterol, HbA1c, c-peptide, glucose, insulin, homeostatic model assessment-insulin resistance (HOMA-IR), IL-6, hsCRP, and TNF-α among obese children with diabetes. However, serum sestrin-2 level was correlated inversely with these parameters. Higher expressions of both microRNA-29a and microRNA-122 among obese children either with or without diabetes mellitus (DM) can suggest their roles in the development of obesity among children.

Conclusions

The study results can hypothesize that down-regulation of these micro-RNAs may solve this health problem with its sequelae, a hypothesis that needs more studies.
Fixed-point theory and numerical analysis of an epidemic model with fractional calculus: Exploring dynamical behavior
Authors: Alshehry Azzh Saad , Mukhtar Safyan , Khan Hena Saeed , Shah Rasool
Published: November 2023

The human immunodeficiency virus, which attacks the immune system and especially targets CD4 cells that are crucial for immunological defense against infections, is the cause of the severe illness known as acquired immunodeficiency syndrome (AIDS). This condition has the potential to take a patient’s life. Understanding the dynamics of AIDS and evaluating potential methods of prevention and treatment have both significantly benefited from the use of mathematical modeling. This research article proposes a unique technique that solves a model system of differential equations representing diverse populations, such as susceptible populations, acute populations, asymptomatic populations, and symptomatic populations or populations with AIDS. The method uses an artificial neural network (ANN) to do this. A specific Caputo–Fabrizio derivative is included in the suggested method to validate the system’s stability via the use of Krassnoselskii’s and Banach’s fixed-point approach in combination with the exponential kernel. In order to solve the differential equations and get the required data, the Laplace Adomian Decomposition (LAD) technique is used. Training the ANN involves obtaining simulated data from LAD and doing it within the context of a supervised learning framework. The performance of the ANN is assessed by comparing its predicted solutions to the LAD solutions. This allows for the calculation of the average error for each of the system’s functions. This study presents a potentially useful computational tool for understanding the dynamics of AIDS and delivering important insights into the design of new prevention and treatment methods.
Efficient extraction of 68Ge from irradiated Ga–Ni alloy via a novel organic-solvent-free separation procedure
Authors: Xia Lingting , Wu Han , Gao Jing , Ye Tianzhen , Qiu Long , Li Feize , Lan Tu , Yang Jijun , Liao Jiali , Liu Ning , Yang Yuanyou
Published: November 2023

In this work, a gallium–nickel alloy target with a weight percentage ratio of 7:3 was successfully prepared on Cu substrate in a chloride system at room temperature. A novel organic-solvent-free separation procedure based on two columns for extracting 68Ge from irradiated Ga–Ni alloy target with high radionuclidic purity (99.99 %) was developed. By this separation procedure, the recovery of 68Ge is 95 ± 5 % and the yield of 68Ge via the nuclear reaction natGa(p,xn)68Ge was measured to be 0.27 ± 0.02 MBq/μA h.
Party Affiliation and Voting Behavior
Authors: Shoaib Muhammad , Sabat Ahmad , Iqbal Khuram
Published: November 2023

A study of the last four national elections (2002, 2008, 2013, and 2018) in Pakistani Punjab indicates how affiliation with political parties develops and varies in the province. In urban areas, parties have a relatively stable presence and hardened loyalists. However, in less-developed and rural areas they rely on electables and politically influential families, which limits their choices in nominating candidates. In the latter areas, voters care more about candidates and kinship than about parties and their manifestos.
A Preregistered Field Study of the Trust Inoculation Against a Negative Event Involving Geothermal Energy Systems
Authors: Spampatti Tobia , Brosch Tobias , Trutnevyte Evelina , Hahnel Ulf J. J.
Published: November 2023

Psychological inoculations are hailed as one of the most promising evidence-based techniques to preemptively protect public support against negative information and events, especially in time-sensitive domains like climate change mitigation and energy transitions. However, field testing of these techniques is limited, and their ecological validity thus remains to be investigated. In Fall 2021, a prospecting campaign for geothermal exploration in Geneva, Switzerland deployed seismic trucks at night that created noise and seismic vibrations which could negatively affect public support for geothermal energy systems. Here, we employed a trust inoculation in a preregistered, longitudinal field study, to make the trustworthiness of the responsible utility company salient to protect public support of geothermal energy systems against this local negative event. Contrary to our expectations, we found no evidence that the event affected participants’ public support towards renewable energy, nor that the trust inoculation influenced said support. This could have been due to the unintended negative influence of the time delay between the delivery of the trust inoculation and the negative event, as the inoculation was more effective with the longest time delay between its delivery and the negative event, but had unintended negative consequences with the shortest delay. We conclude by placing these results in the growing psychological inoculations literature and providing recommendations for future field studies for psychological inoculations.
Novel, Organism, Form
Authors: Suther Jensen
Published: November 2023

This essay intervenes in the contemporary debate surrounding the Bildungsroman and its roots in German Idealism through a new reading of the idea of “life” in two major modern texts: G. W. F. Hegel’s Lectures on Fine Art and the famous “Research” chapter of Thomas Mann’s The Magic Mountain. I establish three key points: 1) Hegel pioneers a bio-aesthetics that grasps the work of art as a distinctly social and historical, reflective manifestation of organic life; 2) Mann’s novel achieves a kind of self-conscious knowledge of the Bildungsroman in particular as such a manifestation; and 3) Karl Marx’s analysis of the alienation of humanity from its “species-being” under capitalism accounts for the opposition between nature and culture, animality and rationality, that drives Mann’s modernist experiment with genre: his innovation of what I call “the novel of deformation.”
Physical therapy for covid-19 pneumonia on the example of a clinical case
Authors:   S. Gzhytsky Lviv National University of Veterinary Medicine and Biotechnology, Ivasyk N.O.
Published: November 2023

The article presents an analysis of the home program of physical therapy (PT) of a 54-year-old teacher with bilateral segmental COVID - 19 pneumonia. The PT program included classes with an emphasis on improving ventilation of the affected areas with a gradual increase in duration and decrease in the number of classes, and exercises to improve chest mobility and relax the auxiliary respiratory muscles; dosed walking. After 8 weeks of training, there was an improvement in all indicators. According to spirometry, static indicators that indicate the condition of lung tissue were within the age norm. In PT, patients who have suffered from covid pneumonia can hardly be recipe, so it is necessary to focus on the specific problems of the patient to develop an individual program of physical therapy. The PT program is developed taking into account the specific needs of the patient. The first months after discharge are crucial to restore the structure and function of the respiratory system. Overload leads to deterioration of the patient's condition. Online classes complicate the process of monitoring the patient's condition, which can contribute to overload and deterioration of his condition
Physical therapy after elbow fractures joint at the outpatient stage
Authors:   Kharkiv State Academy of Physical Culture, Gyriavy G.G. , Pustovoit B.A. ,   Kharkiv State Academy of Physical Culture
Published: November 2023

To scientifically substantiate, develop and evaluate the effectiveness of the FT program for patients with fractures of the elbow bones at the outpatient stage. Material and methods: analysis of special scientific literature on the problems of physical therapy in fractures of the elbow bones, medical and biological, pedagogical methods, the use of modern computer technology, methods of mathematical statistics. Results: defined modern views on the rehabilitation of patients after fractures of the elbow bones, developed a program of physical therapy. Approbation of the program was conducted on the basis of the medical health center "Fortis" during 2021-2022 with the participation of 15 patients aged 31-40 years (main group - 7, control group - 8). Elbow goniometry, pain intensity tests, and upper limb functional status assessments showed significant improvements in all patients in both groups, but in the main group patients were statistically significantly better. Conclusions. Analysis of the scientific literature has shown that the problem of fractures of the elbow bones is relevant and requires comprehensive treatment using many methods of physical therapy; developed, tested a program of physical therapy that improves the functional state of the upper extremity and restores efficiency in fractures of the elbow bones.
Ankilozan spondilitli bireylerde spinal mobiliteyi etkileyen faktörler
Authors: GUR KABUL Elif , BAŞAKCI ÇALIK Bilge , KURU Sinem , KARASU Uğur
Published: November 2023

Amaç: Bu çalışmanın amacı Ankilozan Spondilit (AS)’li bireylerde spinal mobiliteyi etkileyen faktörleri incelemekti.

Yöntem: Çalışmaya AS tanısı konmuş 18-65 yaş aralığında, yaş ortalaması 43,37±11,56 yıl olan 154 kişi dahil edildi. Katılımcıların demografik (cinsiyet, yaş, boy, kilo, tanı alma süresi, eğitim süresi, çalışma durumu, soygeçmiş, egzersiz alışkanlığı, sigara kullanımı) ve klinik verileri (sabah tutukluğu, kronik solunum hastalık öyküsü) kaydedildikten sonra, mobiliteleri Bath Ankilozan Spondilit Metroloji İndeksi (BASMİ) ile değerlendirildi. Bağımsız grup farklılıkların karşılaştırılmasında Mann Whitney U testi kullanıldı. Sürekli değişkenlerin arasındaki ilişkiler Pearson Korelasyon Analizi ile değerlendirildi.

Bulgular: BASMİ skorları gruplar arasında karşılaştırıldığında; cinsiyet açısından kadınlara göre erkeklerin tragus duvar mesafesi (p=0,013), gövde lateral fleksiyon (p=0,001), lumbar fleksiyon (modifiye Schober) (p=0,001) skorları; çalışma durumu açısından çalışmayanların çalışanlara göre maksimum intermalleoler mesafe (p=0,001) ve toplam BASMI (p=0,019) skorları; kronik solunum hastalığı öyküsü bulunanların bulunmayanlara göre servikal rotasyon (p=0,013) skorları daha yüksekti. BASMİ skorları ile sürekli değişkenler arasındaki ilişki incelendiğinde; yaş ile tragus duvar mesafesi hariç tüm BASMİ skorları arasında orta düzeyde; tanı alma süresi ile maksimum intermalleoler mesafe hariç tüm BASMİ skorları arasında düşük ve orta düzeyde; eğitim süresi ile tüm BASMİ skorları arasında düşük ve orta düzeyde ilişki vardı (p
Estilos parentais e problemas de comportamento em crianças assistidas em um serviço básico de proteção do Sistema Único de Assistência Social brasileiro
Authors: Wielewski Pobbe Mainardes Liliane , Zazula Robson , Caserta Gon Márcia Cristina
Published: November 2023

O presente estudo objetivou investigar relações entre estilos parentais e a ocorrência de problemas de comportamento em crianças atendidas por um serviço básico de proteção vinculado ao Sistema Único de Assistência Social em um município do estado do Paraná. Participaram do estudo 37 cuidadores de crianças entre 6 e 11 anos de idade. Foram aplicados o Questionário de Capacidades e Dificuldades (SDQ) e o Inventário de Estilos Parentais (IEP). Dados sociodemográficos foram também coletados. Houve diferenças significativas entre gênero para problemas de comportamento, hiperatividade/ falta de atenção, comportamento pró-social e escore total do SDQ; e para monitoria negativa no IEP. Foi identificado ainda fracas correlações positivas e negativas entre subescalas do SDQ e IEP. Estilos parentais e problemas de comportamento estão relacionados, em particular no contexto de condução da pesquisa. Adicionalmente, as condições socioeconômicas podem ser consideradas uma variável importante no surgimento e na manutenção de problemas de comportamento.
Kochanek Sybilli Thompson Marii Pawlikowskiej-Jasnorzewskiej – Utopia czy dystopia?
Authors: Banot Aleksandra E.
Published: November 2023

Maria Pawlikowska-Jasnorzewska’s futurological fantasy from 1926 entitled Kochanek Sybilli Thompson (The Lover of Sybilla Thompson) seems to be a realistic social utopia. On the one hand, it reflects the spirit of the moral revolution of the interwar period and refers to the beginnings of aesthetic medicine and cosmetic treatments aimed at rejuvenation. On the other hand, it heralds – how aptly – the era of hippie free love, polyamorous relationships of the 1970s, the time of the next sexual revolution, but also the time of much more advanced plastic surgeries and cosmetic technologies. However, a careful reading of the drama allows us to see the critical (and also satirical) dimension of the story about a seventy eight-year-old woman who decided to rejuvenate herself in order to experience physical love once again. Joyful utopia becomes sad dystopia. In my article I look at this dualism: utopian – dystopian, realistic – fantastic, joyful – sad, young – old, modern – conservative, and the game of tension between oppositional concepts.
Obraz domostwa w przysłowiach Śląska Cieszyńskiego
Authors: Kawala Kolberová Urszula
Published: November 2023

The purpose of this article is to determine what the image of the house looked like in the past in Cieszyn Silesia, how the house was perceived what were their mutual relations. The research used the methodology of the linguistic picture of the world. The research material was Józef Ondrzusz’s publication Przysłowia i przymówiska ludowe ze Śląska Cieszyńskiego.
La salud trans en Argentina. Una revisión de publicaciones en revistas científicas (2012-2021)
Authors: Farji Neer Anahí
Published: November 2023

Este artículo aborda diferentes modos de problematización de la salud de la población trans en Argentina desde la sanción de la Ley 26.743 de Identidad de Género en 2012. Se realizó una revisión bibliográfica de artículos científicos publicados en las bases de datos SciELO, PubMed y LILACS. Se incluyeron artículos de investigación publicados entre 2012 y 2021 que abordaban dimensiones vinculadas a la salud de la población trans en Argentina. Se identificaron dos modalidades de producción de saberes sobre la salud trans. La primera colocaba como punto de partida el concepto de estigma para explicar los procesos de vulnerabilidad social que impactaban en la salud de la población trans. La segunda abordaba distintas respuestas propositivas frente a la vulneración de derechos de la población trans en los ámbitos de salud delineadas tanto por la propia población trans como desde las instituciones de salud.
Analysis of selected pro-inflammatory cytokines: IL-1β, IL-6, CXCL-8, and TNF-α in children with seizure disorders during acute infection. Is there a specific pro-inflammatory cytokine profile in these patients?
Authors: Bugaj Grażyna , Mania Anna , Frydrychowicz Magdalena , Górna Agnieszka , Lubarski Karol , Mazur-Melewska Katarzyna , Figlerowicz Magdalena
Published: November 2023

Introduction and objective: This study aimed to analyse the levels of selected pro-inflammatory cytokines in children with seizures during acute infection. Materials and methods: The study was conducted in the Department of Infectious Diseases and Child Neurology of the Poznan University of Medical Sciences from 19 January 2017 to 5 December 2020. Pro-inflammatory cytokines were measured in 64 patients with febrile seizures and 11 patients after an epileptic seizure in generalised epilepsy. The control group comprised 46 patients with delayed development. Serum pro-inflammatory cytokines were determined using the BioLegend’s ELISA MAX™ Deluxe Set. Pathogens were detected by standard diagnostic methods. Total white blood cell count, C-reactive protein and procalcitonin were determined using standard diagnostic methods. Results: Significantly higher levels of all analysed pro-inflammatory cytokines were found in patients with simple and simple plus febrile seizures; interleukin 6, CXCL-8 in those with complex febrile seizures; interleukin 6, CXCL-8, tumour necrosis factor α following epileptic seizure. The intensity of the inflammatory response in simple and simple plus febrile seizure patients corresponded to significantly higher levels of all pro-inflammatory cytokines and inflammatory markers. Pro-inflammatory profiles differed depending on the aetiology of the infection. Significantly higher levels interleukin 6, CXCL-8, tumour necrosis factor α were found in simple and simple plus febrile seizure patients infected with human herpesvirus-6 compared to the control group. Conclusions: In patients with febrile seizures and epileptic seizures, the involvement of interleukin 1β, interleukin 6, CXCL-8, and tumour necrosis factor α was confirmed in the inflammatory process, with a different distribution in the analysed groups. Pro-inflammatory cytokine profiles varied depending on the infectious aetiology.
Young-onset dementia – possible causes and effects on patients’ lives
Authors: Leś Klaudia Karina , Lipska Julia , Lewtak Julia
Published: November 2023

For years, there has been an ongoing myth that dementia diseases affect only elderly people. However, in recent years, with the development of medicine and growing awareness of “new” diseases, more and more cases of the so-called “young-onset dementia”, also known as “early-onset dementia” or even “working-age dementia” have been described. The disease can lead to job loss, changes in relationships with loved ones, and the necessity of providing constant care. The story of a 19-year-old boy from China who has been recently diagnosed with Alzheimer’s disease (Jia et al., 2023) inspired us to find out more about that condition, as there are still gaps in knowledge about that topic and a lot to discover, especially among people outside the medical environment. Despite claims that most of the information about this condition so far comprises theories, and there is still extensive research to be done, the authors decided to gather the key data and summarise them in this narrative review, with a view to raising awareness about this growing problem and about the lack of correct diagnosis, help for the patients, and the effects this condition has on the daily life of young people.
Autoimmune encephalitis with anti-NMDAR antibodies – variety of clinical manifestations
Authors: Sierakowska Alicja , Roszak Mateusz , Łabuz-Roszak Beata
Published: November 2023

The aim of this study was to review the literature on the topic of diversity of clinical symptoms of autoimmune encephalitis with the presence of antibodies against N-methyl-D-aspartate receptors (anti-NMDAR antibodies), the diagnostic process, and treatment. The incidence of the disease is approximately 4% of all reported cases of encephalitis. Autoimmune encephalitis with anti-NMDAR antibodies manifests as a rapidly progressive encephalopathy of acute or subacute onset. It usually develops over a period of six weeks. To diagnose the disease, it is necessary to confirm a minimum of four out of six symptoms, such as behavioural or cognitive impairment, speech impairment, epileptic seizures, movement disorders, disturbances of consciousness, and autonomic dysfunction. The diagnostic process is aided by additional examinations including electroencephalography, cerebrospinal fluid examination, magnetic resonance imaging, and laboratory tests (e.g. determination of titre of antineuronal antibodies). It is not uncommon for symptoms to indicate the possibility of co-occurrence of several psychiatric conditions at the same time, leading to a delay in making a correct diagnosis. Moreover, it should be remembered that anti-NMDAR encephalitis often displays the characteristics of a paraneoplastic syndrome, and particularly often coexists with ovarian teratoma. Consequently, this option should be included in the diagnostic process. Autoimmune encephalitis with anti-NMDAR antibodies can manifest itself in many ways, often with multiple neurological and psychiatric symptoms. Quick diagnosis, as well as early targeted treatment, increase the chance of success of the therapeutic process.
Validación española de la Escala de Detección de altas capacidades, «Gifted Rating Scales 2 (GRS 2-S) School Form», para profesores
Authors: Tourón Marta , Tourón Javier , Navarro-Asencio Enrique
Published: November 2023

En este trabajo se aborda el primer estudio sobre la validez de constructo de la Escala de Detección para profesores GRS 2 en España, sobre una muestra de 348 sujetos. Se llevó a cabo un estudio factorial confirmatorio, AFC, utilizando procedimientos de estimación (WLSMV) de mínimos cuadrados robustos. Se ha seleccionado una estructura de seis factores que explica el 66% de la varianza. Los índices de ajuste del modelo son satisfactorios (CFI, ,93; TLI, ,93). La validez convergente (AVE, ,66) y la fiabilidad compuesta (entre ,87 y ,96) son adecuadas. Esta escala es la primera validada en España y aporta una medida relevante para la identificación de los alumnos con alta capacidad.
THE EFFECT OF ROXADUSTATE ON ERYTHROPOIESIS OF DIALYSIS-DEPENDENT AND DIALYSIS-INDEPENDENT PATIENTS WITH CHRONIC KIDNEY DISEASE
Authors: Dmitrievskaya M. , Galata Anastasiya
Published: November 2023

Anemia is a common condition in patients suffering from chronic kidney disease. To correct it, a new class of drugs has been developed – prolyl hydroxylase inhibitors. There are able to stimulate the se-cretion of endogenous erythropoietin regardless of oxygen availability, even in patients with end-stage disease. Prolyl hydroxylase is an enzyme that cleaves the alpha subunit of hypoxia-induced factor, which enhances the expression of genes that are responsible for erythropoiesis. Roxadustat is one of the first oral drugs that induce the production of endogenous erythropoietin in patients with renal ane-mia by activating hypoxia-induced factors. Recent results of phase III clinical trials of roxadustat have demonstrated its efficacy and safety. So, for patients who do not need dialysis, roxadustat, compared with placebo, increased the level of hemoglobin by 18.5 g/l, placebo – by 1.3 g/l. In the group of pa-tients on dialysis, the effects of roxadustate and epoetin alpha were compared. The hemoglobin level increased by 12.2 g / l when taking roxadustate, and by 9.9 g / l when taking epoetin. In addition to the main effect, roxadustat also reduced the content of hepcidin, low-density lipoproteins and cholesterol.
Microminerals in Kimberlites
Authors:   Perm State University, Osovetsky B. M.
Published: November 2023

The peculiarities of kimberlite micromineral assemblages are described. The previous investigations results are analyzed and presented in the paper as well. The typical microminerals (main grains less than 5 µm in size) in 7 kimberlite tubes of Yakutiya (Nachalnaya, Novinka-1, 2, 4, Vodorazdelnaya, Obnazhennaya, Sytykanskaya) were studied in details under scanning electron microscope. The objects of investigations are included as the microminerals in large crystals, binding substance, and the kimberlites alteration products. The characteristic differences in chemical composition of indicative components (intermetals, sulfides, silicates, etc.) are revealed that may be used for evaluation of diamondiferousness of kimberlites