bluuebunny/crossref_metadata_2025 huggingface dataset:
Pensamiento económico contemporáneo: los Premios Nobel en Ciencias Económicas. Consideraciones didácticas
Authors:   Universidad de Guadalajara, Cortés Fregoso José Héctor
Published: June 2023

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Estado Socioeconómico de la Región 07 Sierra de Amula del estado de Jalisco
Authors:   Universidad de Guadalajara, Venegas Herrera Carmen , Castañeda Huizar Porfirio ,   Universidad de Guadalajara
Published: June 2023

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Políticas globales y económicas: análisis de su impacto sobre el género
Authors:   Instituto Nacional de Investigaciones Forestales, Agrícolas y Pecuarias, Campo Experimental Valle de México, Sangerman-Jarquín Dora María , Schwentesius De Rindermann Rita ,   Universidad de Guadalajara, Espitia Rangel Eduardo ,   Instituto Nacional de Investigaciones Forestales, Agrícolas y Pecuarias, Campo Experimental Valle de México, Turrent Fernández Antonio ,   Instituto Nacional de Investigaciones Forestales, Agrícolas y Pecuarias, Campo Experimental Valle de México, Cuevas Sánchez Jesús Axayacatl ,   Banco de Germoplasma, Universidad Autónoma Chapingo.
Published: June 2023

El objetivo de este documento es analizar tres aspectos: políticas globales, económicas y género; articularlos e interrelacionarlos. Diversos resultados de investigaciones han demostrado la estrecha relación de estos componentes en un intento por integrarlos desde el análisis de los mencionados tres aspectos, tomando en consideración los cambios efectivos en la vida de las mujeres en general. Asimismo, se puntualiza un considerable número de factores en estos tres aspectos, que se dan como consecuencia de las políticas macroeconómicas de este mundo globalizado, haciendo referencia a sus implicaciones en el terreno económico, político, social y cultural. Se concluye con una serie de puntos con el fin de contar con elementos que permitan diseñar estrategias públicas, económicas, políticas y sociales encaminadas a proporcionar apoyo a este grupo vulnerable de la población, el cual contribuye en gran medida con su trabajo productivo y reproductivo al desarrollo del país.
Análisis económico: México-Venezuela 1989-2014
Authors:   Universidad de Guadalajara, Comparán Ferrer Alejandro José , Jiménez Reynoso Carmen Leticia ,   Universidad de Guadalajara, Vives Urbina José Tomás ,   Universidad de Guadalajara
Published: June 2023

El presente trabajo busca comparar el crecimiento económico de México con el de Venezuela y conocer el bienestar de ambos países. El período de estudio va del año de 1989 a 2014.
Empleo femenino y la precariedad laboral en la industria electronica y de autopartes en Jalisco: dos estudios de caso, la empresa electronica Jaibil Vircuit de mexico y la empresa de autopartes sistemas de Arneses K&S, Mexicana, sa de cv
Authors:   Universidad de Guadalajara, Delgado Lecourtois Carmen Yolanda , Peyro Beltrán Maria Elena ,   Universidad de Guadalajara
Published: June 2023

El presente estudio tiene como objetivo evaluar el empleo femenino y la precariedad laboral de la industria electrónica y de autopartes en Jalisco. Ramas productivas que pesar de los retos económicos, que han implicado las crisis económicas de los años 2001 - 2008 obtienen un alto nivel de ganancias. Cabe señalar, que buena parte del análisis y de la información que aquí se presentan, se basan en el trabajo de campo, tanto en la empresa de la industria electrónica Jabil Circuit de México (JABIL) y de autopartes Sistema de Arneses K&S, Mexicana, S.A. de C.V. en Jalisco. La precariedad será analizada a través de considerar dimensiones tales como el salario mínimo, contrato de trabajo, jornada de trabajo, acceso a la seguridad social, prestaciones sociales y de sindicalización, entre otras.
Efficacy of auricular acupuncture combined with electro-acupuncture and physiotherapy exercise in motor rehabilitation after ischemic stroke
Authors: Nguyen Duong Thi Huong , Trinh Dieu Thuong Thi
Published: June 2023

Auricular acupuncture (AA) is a method of Traditional Medicine that has been used for a long time to treat many diseases, including stroke. This study aimed to examine the effect of auricular acupuncture combined with electro-acupuncture and physiotherapy exercise in the motor rehabilitation of patients with ischemic stroke. 128 patients after ischemic stroke participated in this RCT, then were randomly assigned to either the AA-study group (auricular acupuncture combined with electro-acupuncture and conventional therapy) or the CT - control group (sham auricular acupuncture combined with electro-acupuncture and conventional therapy). They were treated and monitored for six consecutive weeks. Clinical outcomes were measured using the Barthel Index (BI), Fugl Meyer Assessment (FMA), and Motricity Index (MI) scales at two-time points, including before and six weeks after initiation of the intervention. After six weeks, FMA, BI, and MI scores were significantly higher than before treatment (p < 0.05) in both groups. Specifically, the study group had a statistically significant improvement compared to the control group (p < 0.05). This study shows that auricular acupuncture in combination with electro-acupuncture and physiotherapy exercise was more effective than electro-acupuncture and physiotherapy exercise in improving motor function in patients after ischemic stroke.
On Boundaries And Apertures: Drawing A Vulnerable + Intimate Architecture
Authors: Orzechowska Maya
Published: June 2023

The boundaries and apertures of home are not separate from but play an active role in a politics of body and social body health. As both the idea of home and housing fail increasing numbers of people, this thesis seeks alternatives to home’s narrative of utopic internal intimacy that endorses retreat and a relationship of non-responsibility vis à vis the public realm. It suggests the result is dystopic in its concealment and exacerbation of vulnerability and its resistance to change. Instead, a vulnerable and intimate architecture centers the vulnerable body to uncover unique, pluralistic, personal intimacies. To draw out the uncanny, repressed and emotional in home, Five Principles are proposed based on Corbusier’s calibration of the subject and values of modern architecture. It seems time to reevaluates architecture’s inside and outside, to speculate on new homes and new understanding of self in relation one’s neighbours, in the broadest sense. 
Managing of responsible consumption and sustainable production enterprises in the glocalization conditions
Authors: Tepliuk Mariia , Sahaidak Mykhailo , Petrishyna Tetiana , Fokina-Mezentseva Katerina , Fomenko Boris , Vasyliev Igor
Published: June 2023

The article discusses principal issues related to lean production and consumption, providing the author's perspective on the factors and initiatives necessary for their implementation. The paper emphasizes the importance of each stakeholder's role in sustainable development. The agricultural market is analyzed, and general steps for implementing a Sustainable Development Strategy are proposed, including simulations of sales and pricing policies after the introduction of sustainable development aspects. With the world's population growing and resources declining, there is a need to meet increasing demand while also conserving water resources, agricultural land, and promoting environmentally friendly labour practices. To achieve this, countries must adopt innovative approaches to responsible consumption and sustainable production, particularly considering the socio-economic impact of COVID-19. Therefore, it is essential to develop an innovative model of sustainable consumption and production. COVID-19 has become a catalyst for socio-economic change, highlighting the adaptability of countries to change and the necessity for effective restoration and implementation of sustainable production and consumption models. This article explores the management of responsible consumption and sustainable production enterprises in the context of glocalization. It analyses the impact of global trends and local contexts on businesses striving for sustainable development. The article emphasizes the role of leadership, strategic planning, and the implementation of effective management practices in achieving these goals. The authors examine various models and approaches to managing responsible consumption and sustainable production, including concepts of green manufacturing, circular economy, and corporate social responsibility. They consider advanced practices and initiatives in these areas that are already successfully implemented by large and small enterprises. The article also investigates the influence of glocalization on enterprise management. Glocalization is defined as the convergence of global and local factors influencing businesses. It highlights the need for enterprises to adapt their strategies and operations to the specific cultural, social, and environmental contexts in which they operate, while also addressing global challenges related to responsible consumption and sustainable production.
The role of Artificial Intelligence in the development of railway transportation
Authors: Ficzere Péter
Published: June 2023

Artificial intelligence (AI) has been a revolutionary force in modern transportation systems. In recent years, AI has played an important role in the development of railway trans-portation. This paper explores the role of AI in railway transportation and the potential impact it may have on the industry. The paper begins by discussing the different types of AI tech-nologies that are being used in railway transportation. It then examines the advantages of AI in railway transportation, including improved safety, increased efficiency, and reduced costs. Finally, the paper discusses the challenges associated with implementing AI in railway trans-portation and concludes with a discussion of future developments in this area.
Investigation of the involute spur gears with different pressure angles
Authors: Pintér Ádám Sándor , Sarka Ferenc
Published: June 2023

This article deals with an investigation of the choice of the profile shift coefficient for gears when the standard pressure angles of the gears are different. The basic idea for the study arose from a real-life problem where a gear in a piece of equipment needed to be re-placed. In this article, a method is presented to determine, by approximation, the value of the profile shift coefficient that we have to use on a gear having 20° pressure angle to get similar tooth profile of a gear without profile shift and 21° of pressure angle. In addition, theoretical investigations are also carried out on the topic of gear meshing, using the profile shift coef-ficient.
Research on the Construction of Ecological Museum and the Active Participation of Community Masses: A Case Study of Yim Tin Tsai Village in Hong Kong
Authors: Liu Ruixi
Published: June 2023

The construction of ecological museums under the guidance of the new museum theory has been widely used in the protection and utilization of traditional villages, historical blocks, industrial heritage, etc., in China. The concept of new museum science has become a new practice and thinking in building eco-cultural towns and eco-cultural communities (Pan, 2018). The construction concept of the Ecological Museum of Yim Tin Tsai Village Village in Hong Kong is a theoretical attempt to study and solve the long-term development of Yim Tin Tsai Village. This article mainly demonstrates the community mass active participation mode that Yim Tin Tsai Village faces in the construction of the ecological museum. Through data analysis, examples and other methods, and by desktop deduction and research, we will carry out practical analysis to improve the active participation of community people in community management mode and plan to realize the role of community people in actively participating in the construction and management of ecological museums, realize the new idea of overall ecological conservation, and let local people's participation and community governance interact and work together. At the same time, most of the current domestic research on community creation is focused on mainland villages, and few researchers have focused on villages in Hong Kong. Yim Tin Tsai Village in Hong Kong as an excellent representative of new rural tourism development has formed a relatively mature model of community participation in the construction of the eco-museum, and the need for research has thus emerged.
ASOSIASI KEMAMPUAN KONEKSI DAN KEMAMPUAM KOMUNIKASI MATEMATIS SISWA SMP MELALUI PEMBELAJARAN BERBASIS ICT
Authors: Farhan Wahyu Puadi Evan , Umbara Uba
Published: June 2023

Penelitian ini bertujuan untuk melihat adanya asosiasi kemampuan koneksi dengan kemampuan komunikasi matematis siswa. Kedua kemampuan tersebut memiliki hubungan yang menarik dalam penyelesaian masalah matematis di sekolah. Dengan menerapkan pembelajaran berbasis ICT, data dikumpulkan melalui instrument tes. Populasi adalah seluruh siswa MTsN 3 Kuningan Kelas VII, dengan pengambilan sampel menggunakan purposive sampling sejumlah 80 siswa. Metode penelitian yang digunakan adalah eksperimen dengan desain One – Group Pretest-Posttest Design. Pengolahan data menggunakan SPSS yang menghasilkan nilai Asymptotic Significance (2-sided) = 0,000. Karena harga Sig. lebih kecil dari α = 0,05 , maka hipotesis nol ditolak yang artinya terdapat asosiasi yang signifikan antara kemampuan komunikasi matematis dengan kemampuan literasi matematis siswa. Kesimpulan akhir yang diperoleh dari penelitian ini Berdasarkan kriteria penggolongan koefisien kontingensi diketahui bahwa asosiasi antara kemampuan komunikasi matematis dengan kemampuan koneksi matematis siswa tergolong tinggi.
A globalização neoliberal e a mitigação de direitos dos trabalhadores na América Latina
Authors: Cicília Araújo Nunes  , Juliane Caravieri Martins  , Daniela de Melo Crosara
Published: June 2023

A temática da presente pesquisa versa sobre os impactos da aplicação do receituário neoliberal no cenário laboral e socioeconômico dos países da América Latina, notadamente na Argentina, México e Brasil. A pesquisa se propõe a analisar a seguinte problemática: as sucessivas reformas legislativas efetivadas na América Latina se coadunam com os preceitos da garantia dos direitos sociais, notadamente dos laborais? Nesse sentido, o objetivo geral da pesquisa é identificar a maneira como o neoliberalismo rege as relações socioeconômicas no panorama da América Latina e destacar a importância das políticas de geração de trabalho e emprego pautadas na garantia de condições laborais dignas. A técnica de pesquisa consiste na análise crítica das reformas trabalhistas da Argentina, México e Brasil por meio da utilização de material bibliográfico-doutrinário interdisciplinar referente à (des)proteção dos direitos sociais da classe trabalhadora latino-americana. A pesquisa conclui que o neoliberalismo tem influenciado reformas trabalhistas no âmbito da América Latina com caráter precarizante dos direitos humanos e fundamentais, notadamente dos sociais, cenário que impõe a necessidade de mudança de paradigma com o intuito de viabilizar a garantia de um patamar civilizatório mínimo e a efetivação progressiva dos direitos humanos e fundamentais.
Prevalence of zoonotic diseases of small ruminants at Savar upazila of Dhaka district
Authors: Hossain H , Islam M R , Sajib M S I , Hossain M M , Begum M , Islam K B M S
Published: June 2023

The objective of this study was to assess the prevalence of zoonotic diseases of small ruminants (SR) at Savar upazila of Dhaka district. A questionnaire-based survey was conducted in small and middle-scale goat and sheep farms at Savar Upazila with a total number of 1981 SR (1438 goats and 543 sheep). We found a total of 468 diseased SR (281 goats and 187 sheep), of which 206 cases were zoonotic (41.37%) (124 / 60% goats; 82/40% sheep). Prevalence of bacterial zoonoses (Salmonellosis, Tetanus Dermatophilosis, Brucellosis, Listeriosis and Campylobacteriosis ) was higher (23.78% in goat and 15.53% in sheep) followed by that of parasitic zoonoses (Hydatidosis, Fascioliasis, Amphistomiasis and Cryptosporidiosis) (17.48% in goat and 11.65% in sheep), viral zoonoses (Contagious Ecthyma, Foot and Mouth Disease and Rabies) (12.14% in goat and 7.77% in sheep), rickettsial zoonoses (Q Fever) (2.91% in goat and 1.94% in sheep). The age-wise, sex-wise and breed-wise prevalence of zoonotic diseases in goats and sheep were also determined. The study provided an epidemiological forecast showing the prevalence of zoonotic diseases of SR, which can be helpful for the clinician in the diagnosis of such infections. The present study revealed that the SR at Savar Upazila is susceptible and also infected with various zoonotic diseases. So, prevention and control of these zoonotic diseases are essential.
Bangladesh J. Agri. 2023, 48(1): 81-91
Yunus Emre Şiirlerinde Felsefi Sağaltımın İmkanı
Authors: FİLİZ Şahin , KÖSEOĞLU Mustafa
Published: June 2023

Felsefi sağaltım, bir hastalık aşamasına gelmemiş kişi veya kişilerin, geniş manada toplumun, yaşadığı varoluşsal ve ahlaki problemleri, felsefenin tüm teknik ve yöntemlerini kullanarak insan sağlığı üzerinde iyileşmeyi amaçlayan bir danışmanlık sürecidir. Felsefe, insan ve toplumun eunoia’ya yani, “güzel düşünme”ye, “iyi dengelenmiş bir zihne sahip olma”ya ve sonunda “iyi niyet”e ve “nezaket”e ulaşmanın yol ve yöntemlerini araştırmaktır; bu kapsamda da felsefi sağaltım harekete geçmektedir. Yunus Emre’nin üretmiş olduğu şiirlerinden hareketle, felsefi sağaltımın icra edilebileceği düşünülmektedir. Yunus Emre Şiirlerinde Felsefi Sağaltımın İmkanının Araştırılması, daha önce çalışılmayan konudur. Yunus Emre’nin şiirleri, düşünce bütünlüğünün ve hümanizmin tüm alanlarını ilgilendirerek, insanın ruhen ve bedenen iyileşmesini sağlar. “Gelün tanşuk idelüm işi kolay tutalum, sevelüm sevilelüm dünyâ kimseye kalmaz” diyen Yunus Emre, herkese uygun üslubu, döneminin tüm bilimlerini ve temelinde insanın sevilme ile sağaltımını içeren kapsayıcı üslubu ve yaşadığı dönemdeki ruhsal ve toplumsal rahatsızlıkları insanların zihnini uyandırarak sağaltmıştır. Bu çalışmada, şiirlerinde “insan”, “insanlık” ve “insan değerleri” üzerinde önemle duran Yunus Emre’nin, yukarıdaki örnekteki gibi, şiirleri aracılığıyla, yaşadığı dönemin sıkıntı ve buhranlarından insanları kurtarmaya ve insanlara iç huzur yükleyerek, ruhen ve bedenen felsefi sağaltımlarını sağlamaya ve iyileştirmeye çalıştığı ve şiirleri ile insanda iyileşmenin nasıl olduğu ortaya konulmaya çalışılmıştır.
Growing Leadership Spirit in Students Through the Concept of Khalifah fil Ardhi
Authors: Rohana Rohana
Published: June 2023

Abstract: This paper describes the concept of khalifah fil ardhi as God's representative in prospering the earth. Humans as khalifah fil 'ard have two meanings, namely khalifah in the sense of head of state and caliph as a substitute and inhabitant of Allah's earth. This research includes literature study, The type of data collected is in from various articles, papers,library sources and appropriate documents. The data obtained,  then collected,   compiled,   reviewed,   analyzed,  and concluded so as to obtain recommendations regarding the study of literature. This paper aims to instill awareness in students to realize the spirit of leadership as an effort to build, care for, and preserve the earth. Students as educated human beings have an urgent task as a leader and it is necessary to develop a leadership spirit. Things that students can do include; (1) become a learner (learner), (2) become an observer (heart) and, (3) become a thinker (thinker) and care. These three things are expected to be understood and applied in everyday life as an effort to foster a leadership spirit in students. Keywords: Leadhership, Student, Khalifah fil ArdhiAbstrak: Tulisan ini menjelaskan tentang konsep khalifah fil ardhi sebagai wakil Tuhan dalam memakmurkan bumi. Manusia sebagai khalifah fil ardhi mempunyai dua arti, yaitu khalifah dalam arti kepala negara dan khalifah sebagai pengganti dan penghuni bumi Allah Swt. Penelitian ini termasuk ke dalam jenis penelitian studi literature. Jenis data yang dikumpulkan berupa hasil penelitian dari berbagai artikel, makalah, sumber pustaka dan dokumen yang sesuai. Data yang diperoleh kemudian dikumpulkan, disusun, ditelaah, dianalisis, dan disimpulkan sehingga diperoleh rekomendasi terkait kajian kepustakaan. Tulisan ini bertujuan untuk menanamkan kesadaran pada mahasiswa agar terwujudnya jiwa kepemimpinan sebagai upaya membangun, merawat, dan melestarikan bumi. Mahasiswa sebagai manusia yang terpelajar mempunyai tugas yang urgent sebagai pemimpin dan perlu ditumbuhkannya jiwa kepemimpinan. Hal yang dapat dilakukan mahasiswa diantaranya; (1) menjadi seorang pem(belajar), (2) menjadi seorang pemer(hati) dan, (3) menjadi seorang pe(mikir) dan peduli. Ketiga hal tersebut diharapkan dapat dipahami dan diterapkan dalam kehidupan sehari-hari sebagai upaya dalam menumbuhkan jiwa kepemimpinan pada diri mahasiswa.Kata Kunci: Jiwa Kepemimpinan, Mahasiswa, Khalifah fil Ardhi
Limited impact of a bioeroding sponge, Cliona sp., on Ostrea chilensis from Foveaux Strait, New Zealand
Authors: Böök IM , Michael KP , Lane HS , Cornwall CE , Bell JJ , Phillips NE
Published: June 2023

Bioeroding sponges can cause extensive damage to aquaculture and wild shellfish fisheries. It has been suggested that heavy sponge infestations that reach the inner cavity of oysters may trigger shell repair and lead to adductor detachment. Consequently, energy provision into shell repair could reduce the energy available for other physiological processes and reduce the meat quality of commercially fished oysters. Nevertheless, the impacts of boring sponges on oysters and other shellfish hosts are inconclusive. We studied the interaction between boring sponges and their hosts and examined potential detrimental effects on an economically important oyster species Ostrea chilensis from Foveaux Strait (FS), New Zealand. We investigated the effect of different infestation levels with the bioeroding sponge Cliona sp. on commercial meat quality, condition, reproduction, and disease susceptibility. Meat quality was assessed with an index based on visual assessments used in the FS O. chilensis fishery. Meat condition was assessed with a common oyster condition index, while histological methods were used to assess sex, gonad stage, reproductive capacity, and pathogen presence. Commercial meat quality and condition of O. chilensis were unaffected by sponge infestation. There was no relationship between sex ratio, gonad developmental stage, or gonad index and sponge infestation. Lastly, we found no evidence that sponge infestation affects disease susceptibility in O. chilensis. Our results suggest that O. chilensis in FS is largely unaffected by infestation with Cliona sp. and therefore reinforces the growing body of evidence that the effects of sponge infestation can be highly variable among different host species, environments, and habitats.
Push-out Bond Strength of Fiber Posts in Long-Term Hypobaric Pressure Changes
Authors: Ata Secil Ozkan , Ata Nazim , Yazgan Ebru , Akkor Tugce , Ugurlutan Rifat
Published: June 2023

BACKGROUND: The purpose of this study was to evaluate the bond strength of fiber posts with different mixing methods and insertion into root canal techniques in long-term hypobaric pressure changes.

METHODS: We chose and decoronated 42 teeth with straight and single root canals. After post-space preparation, the posts were cemented with hand-mixed and auto-mixed resin cements that were inserted into the canals with an endodontic file (lentilo), dual-barrel syringe, and root canal tip (14 for each group). After cementation, each group was divided into two subgroups (N = 7): the control (ambient pressure) group and the hypobaric pressure group. The samples were exposed to hypobaric pressure 90 times. They were cut into 2-mm-thick segments and the push-out bond strength test was performed using a Universal Testing Machine. One-way ANOVA tests, Bonferroni tests, and Student-t-tests were used for statistical analysis.

RESULTS: The environmental pressure changes and insertion techniques affected the bond strength values. The auto-mixed with root-canal tip group showed the highest push-out bond strength values in both hypobaric (dual-barrel syringe group: 10.01 MPa; root-canal tip group: 11.61 MPa) and control (dual-barrel syringe group: 12.29 MPa; root-canal tip group: 14.58 MPa) group. In all root segments, the bond strength values of hypobaric groups were lower than atmospheric pressure groups. The most frequent failure type was adhesive between dentin and cement in all groups.

DISCUSSION: Dentists should use auto-mixed self-adhesive resin with a root canal tip for post cementations in patients likely to be exposed to hypobaric pressure changes.

Ozkan Ata S, Ata N, Yazgan E, Akkor T. Ugurlutan R. Push-out bond strength of fiber posts in long-term hypobaric pressure changes. Aerosp Med Hum Perform. 2023; 94(7):508–513.
Revisions to Acute/Off-Nominal Limits for Benzene in Spacecraft Air
Authors: Ryder Valerie Elizabeth , Williams Edward Spencer
Published: June 2023

BACKGROUND: The previous short-term (1-h and 24-h) Spacecraft Maximal Allowable Concentrations (SMACs) for benzene were established at 10 and 3 ppm by NASA in 1996, based on a study of mice in which no hematological effects were noted following two 6-h exposures to benzene. When the benzene SMACs were updated in 2008, there was no revision to the short-term SMAC limits. Rather, that effort developed a long-term SMAC (1000-d) for Exploration mission scenarios.

Acute benzene exposures can cause numerous neurological effects, and long-term exposure to low levels is well-known to cause acute myeloid leukemia. Since publication of the original benzene SMACs, the National Academy of Sciences developed interim Acute Exposure Guideline Limits (AEGLs) for unintentional releases of benzene into the air. Based on the data used to establish the AEGLs, we have increased our short-term, off-nominal limits for benzene in crewed spacecraft to 40 ppm and 6.7 ppm for 1-h and 24-h, respectively.

Ryder VE, Williams ES. Revisions to acute/off-nominal limits for benzene in spacecraft air. Aerosp Med Hum Perform. 2023; 94(7):544–545.
Comorbidity in inflammatory diseases of joints and spine (clinical aspects)
Authors: Kalinina E. V. , Zvonorenko M. A. , Ansarova A. A. , Goloskova V. P. , Babaeva A. R.
Published: June 2023

The article presents an analysis of the current view of comorbidity problem in rheumatology from the perspective of inﬂammatory disorders of the joints and spine combination with the most common diseases of the internal organs and endocrine system. The data gained from recent sources regarding the frequency and structure of concomitant disorders in patients with rheumatoid arthritis (RA) and spondylarthritis (ankylosing spondylitis [AS] and psoriatic arthritis [PsA]) are presented. It has been shown that the most common comorbidity in patients with RA, AS, PsA are diseases of the gastrointestinal tract and cardiovascular diseases. The authors present the results of their own research on the study of comorbidity in RA, AS and PsA, which are consistent with modern literature data. It is noted that there are speciﬁc disease-associated factors, as well as the negative effect of anti-inﬂammatory drugs in the development and manifestation of comorbid pathology.
The author's complex of hydrokinesiotherapy as method of rehabilitation of patients with rheumatoid arthritis after total hip replacement (preliminary message)
Authors: Khasanov E. R. , Akhtyamov I. F. , Aidarov V. I.
Published: June 2023

Introduction. Rehabilitation of patients with rheumatoid arthritis and polyarthritis after arthroplasty is a debatable and open issue. The main direction in their rehabilitation is physical therapy, and the safest and most convenient way is aqua gymnastics.

The aim. To analyze the clinical and functional results in patients with rheumatoid arthritis after a course of hydrokinesiotherapy after total hip arthroplasty. Materials and methods. Twenty patients after total hip arthroplasty used the bipedal cyclic swimming method (Patent of Russia No. 2733686) to supplement the standard rehabilitation complex. The course consisted of 7–10 lessons and was carried out 1.5 months after the operation. The evaluation criteria were pain syndrome according to the visual analog scale, goniometry, DAS28 (Disease Activity Score in 28 joints), Harris scale and short-HAQ (short Health Assessment Questionnaire).

Results. Eighteen patients remained in the study. They said that active water activities reduced the pain syndrome. In terms of angle measurements, we saw an improvement in ﬂexion and extension in the joint. The study shows that arthroplasty with synovectomy helps to reduce the activity of the disease, and the use of aqua gymnastics in half of the cases supports this trend. All patients improved on the Harris and HAQ scores, but the best scores were in patients who were in remission or had low disease activity before surgery.

Conclusions. The presented method of swimming can improve postoperative results. This study is a pilot one and requires further study using a control comparison group.
Influence of inflammation on lipid profile in chronic rheumatic diseases
Authors: Shilova L. N. , Spitsina S. S.
Published: June 2023

Chronic inﬂammatory rheumatic diseases are associated with an increased risk of cardiovascular disease. In this group of patients, inﬂammation causes various changes in lipid metabolism, which in a chronic course may contribute to an increased risk of atherosclerosis. The most frequent abnormality is decreased serum high-density lipoprotein cholesterol (HDL–C) and increased triglyceride (TG) levels. This imbalance may be due to increased production and secretion of very low-density lipoprotein cholesterol (VLDL–С) in the liver and decreased clearance of TG-rich lipoproteins. The mechanisms by which inﬂammation lowers HDL–C levels are still unclear. Additionally, there is a persistent increase in lipoprotein (a) (Lp[a]) due to its increased synthesis. Thus, systemic inﬂammation negatively affects lipoprotein function: LDL–C oxidation becomes more active since there is the decreased ability of HDL–C to prevent this pathway. Moreover, chronic inﬂammation adversely affects the reverse cholesterol transport mechanism. The greater the severity of the underlying disease is associated with the more pronounced disorders in lipid metabolism. In general, approaches to the correction of lipid metabolism in patients with inﬂammatory rheumatic diseases are similar to those in patients from the general population.
Indonesia - Russia Bilateral Relations: Efforts To Enhance Digital Economy And Tourism Investment Cooperation
Authors: Arry Bainus, Teuku Rezasyah Henry Manurung, Hendra Manurung
Published: June 2023

Indonesia and Russia's bilateral relations still need to be improved and strengthened in all sectors. Both countries agreed in Jakarta in 2021 to enhance and strengthen bilateral cooperation in politics, law, and security. The commitment to further cooperation made by the two major countries in the Asia Pacific aimed at creating peace and maintaining regional and global security stability. This study aims to elaborate how Indonesia's bilateral relations with Russia enhanced are related to the efforts of both generating digital economic cooperation and attracting foreign investment in Indonesia's leading tourist destinations. This study utilizes the concept of dynamic bilateral relations and the implementation of foreign economic policies. The researchers use qualitative research methods with explanatory writing techniques analyzing the data and information obtained. The liberal approach to mutually beneficial international cooperation is further elaborated and analyzed, particularly in understanding how each country's strategic decisions have an impact on sustaining regional economic growth. The digital economy cooperation built by the two countries still needs to be strengthened to attract more incoming Russian investors in the tourism industry. This research reveals that international cooperation has been carried out by the Indonesian government and stakeholders related to tourism management destinations is done through bilateral cooperation, regional cooperation, and multilateral cooperation. It still needs clear strategies that should be implemented tactically as a strategic effort by the Indonesian government and related stakeholders to sharpen the construction of the national digital economy in the sustainable, inclusive, and quality tourism sector in driving and supporting national economic growth.
Mechanical effect of reconstructed shapes of autologous ossicles on middle ear acoustic transmission
Authors: Asakura Takumi , Ito Ryuya , Hirabayashi Motoki , Kurihara Sho , Kurashina Yuta
Published: June 2023

Conductive hearing loss is caused by a variety of defects, such as chronic otitis media, osteosclerosis, and malformation of the ossicles. In such cases, the defective bones of the middle ear are often surgically reconstructed using artificial ossicles to increase the hearing ability. However, in some cases, the surgical procedure does not result in increased hearing, especially in a difficult case, for example, when only the footplate of the stapes remains and all of the other bones are destroyed. Herein, the appropriate shapes of the reconstructed autologous ossicles, which are suitable for various types of middle-ear defects, can be determined by adopting an updating calculation based on a method that combines numerical prediction of the vibroacoustic transmission and optimization. In this study, the vibroacoustic transmission characteristics were calculated for bone models of the human middle ear by using the finite element method (FEM), after which Bayesian optimization (BO) was applied. The effect of the shape of artificial autologous ossicles on the acoustic transmission characteristics of the middle ear was investigated with the combined FEM and BO method. The results suggested that the volume of the artificial autologous ossicles especially has a great influence on the numerically obtained hearing levels.
The in vivo and in vitro corrosion behavior of MgO/Mg-Zn-Ca composite with different Zn/Ca ratio
Authors: Zhang Shuquan , Tang Chaokun , Feng Jiangtao , Wang Qi , Li Chenguang , Zhang Weihao , Zhou Fengxin , Xue Feng , Xu Baoshan , Lyu Shaoyuan , Chen Minfang , Wang Hao
Published: June 2023

The effect of Zn/Ca ratio on the corrosion behavior of Mg–3Zn-0.2Ca-1.0MgO (3ZX) and Mg–1Zn-0.2Ca-1.0MgO (ZX) was investigated on the as-extruded specimens. Microstructure observations revealed that the low Zn/Ca ratio led to the grain growth from 1.6 µm in 3ZX to 8.1 µm in ZX. At the same time, the low Zn/Ca ratio changed the nature of second phase from the existence of Mg-Zn and Ca2Mg6Zn3 phases in 3ZX to the dominated Ca2Mg6Zn3 phase in ZX. The local galvanic corrosion caused by the excessive potential difference was alleviated obviously due to the missing of MgZn phase in ZX. Besides, the in vivo experiment also showed that ZX composite exhibited a good corrosion performance and the bone tissue around the implant grew well.
Design code review on seismic demand and base detailing criteria: an application to wine tanks in Marlborough
Authors: Frezzati Marco , Loporcaro Giuseppe , Buratti Nicola , Palermo Alessandro , Walker Adam
Published: June 2023

Marlborough is the largest wine-growing region in New Zealand. The seismic events of Lake Grassmere 2013 and Kaikōura 2016 caused severe business disruption to the wineries due to the poor performance of wine storage tanks and connected non-structural components. The damage recorded raised two main discussions concerning the NZSEE 2009 guidelines for seismic design of liquid storage tanks. The first is related to the appropriateness of the determination of the importance level to adopt for the design of tanks. In fact, importance level 1 (IL1) (structures presenting a low degree of hazard to life and other property) was adopted for most wine tanks, and therefore, the horizontal forces designed were extremely low. Adopting importance level 2 (IL2) (normal structures) would have increased the overall seismic demand to design them for and therefore limited their structural damage but potentially increased the structural cost. The second concerns the design detailing of the critical connections. In fact, the current guidelines/standards lack provisions. The authors compare the NZSEE 2009 guideline with Eurocode 8 (EC8) and API 650 through the design of six tanks with typical dimensions used in the New Zealand wine industry. Results show that assigning importance level 1 results in seismic design demand similar to EC8 and API 650, thereby showing that other countries have a similar approach to New Zealand. A further comparative analysis also highlighted that connection detailing design including the hierarchy of strength is totally missing in all three standards/guidelines, which lacks information.
Potential utilization of oil shale as a stabilizing material for compressed Earth block
Authors: Al-Fhaid Hamza , Edris Walid Fouad , Al-Tamimi Mahmoud
Published: June 2023

This research aims to produce a compressed Earth block (CEB) product locally from soil collected from North Jordan. The CEB mixture was further stabilized using oil shale (OS) and ordinary Portland cement (OPC). The CEB specimens were thoroughly characterized by studying their mechanical properties (compressive and flexural strength) and durability characteristics (erosion, absorption, and shrinkage tests). Eight mixtures were carried out for the CEB, one of which was the control mix. The other mixtures were carried out by replacing soil with OS, cement, and sand in different proportions. The results showed that higher compressive strength and flexural strength for CEB were obtained in the mixtures that contained 10% of OS and 10% of cement, resulting in an average compressive strength of 10.6 MPa and flexural strength of 0.25 MPa. The absorption increased when the OS increased in the soil. The consequent erosion test was related to the absorption test, where the higher the absorption, the more negative the results of the erosion test. Moreover, oil shale improved the shrinkage properties of the CEB, as the higher the proportion of oil shale in the CEB, the lower the shrinkage. Finally, using oil shale as a stabilizing agent in soil had a clear role in improving the mechanical properties, hiding the shrinkage cracks, and reducing the volume shrinkage value of the CEB.
Excessive load
Authors: Poutanen Tuomo , Pursiainen Sampsa , Länsivaara Tim
Published: June 2023

Sometimes structural loads are excessively high, and a decision must be made if intervention, either removal of the excess load or strengthening of the structure, is needed. This issue was addressed previously in the retrofitting literature. However, equations for excess load calculation were not presented. This article includes equations based on the full probabilistic reliability model for the failure probability of excessive load of three materials: steel, timber, and concrete. Failure probabilities are given as a function of the load designed for full capacity according to the Eurocodes. Safe excessive loads, i.e., loads with a failure probability less than 1/1500, are given, too. The load combination is a critical issue in this study. There are many options for load combination, which vary regarding the dependent vs. independent load combination, dependent vs. independent reliability calculation, the reference time, and the reference reliability. The conclusion is that the loads should be combined dependently, reliability should be calculated dependently, the reference time is 50 years, and the reliability is 50 years. We stress that the reliability of steel structures is questionably low in the current Eurocodes.
Temporal variability of particle flux and its components in the Gotland Basin, eastern Baltic Sea
Authors: Beltran-Perez Oscar Dario , Voss Maren , Pollehne Falk , Liskow Iris , Waniek Joanna Jadwiga
Published: June 2023

Sinking particles were studied by analyzing samples collected in a sediment trap at 180 m depth in the Gotland Basin, eastern Baltic Sea between 1999 and 2020. The aim of this study was to determine the temporal variability of the particle flux and its components and how their changes are linked to phytoplankton blooms. The variables studied included total particle flux, particulate organic carbon and nitrogen, biogenic silica, C:N ratio and the isotopic composition of organic carbon and nitrogen. The total particle flux and its components reached maximum values in 2003, 2012 and 2015. Long-term means over the 22-year period of the total particle flux and its components particulate organic carbon and nitrogen, biogenic silica were estimated at around 152, 22, 3 and 8 mg m−2 d−1, respectively. The C:N ratio and the isotopic composition of organic carbon and nitrogen showed high variability around their long-term means of 9, -25‰ and 4‰, respectively. The annual variability of the components of the flux particulate organic carbon (3–65 mg m−2 d−1), particulate organic nitrogen (0.4–9 mg m−2 d−1) and biogenic silica (1–24 mg m−2 d−1) exhibited the same general pattern as the total particle flux (11–450 mg m−2 d−1) over the study period. On the seasonal scale, sinking material in summer contributed roughly one-third (31%) to the total particle flux, followed by winter (27%), spring (24%) and autumn (19%). The highest particle flux occurred mostly in April, July and November, during and after the appearance of phytoplankton blooms in the Gotland Basin. The phytoplankton community changed from silicon-rich species to nitrogen-fixing cyanobacteria, indicating a shift in nitrogen sources from nitrate-based to N2-based over the year. The spring bloom, dominated by diatoms, was characterized by a lighter carbon and heavier nitrogen isotopic composition, while the summer bloom, mainly of diazotrophic cyanobacteria, was characterized in contrary by heavier carbon and lighter nitrogen isotopes. Although no trend was found in the data, the variability observed in the sinking material was related to the changes over time in the phytoplankton community in the Gotland Basin. The findings of this study provide new and valuable information for our understanding of the temporal variability of sinking material linked to the development of phytoplankton blooms and nutrient sources in the Gotland Basin, and underscore the importance of continued monitoring to understand the potential impacts of environmental changes on this fragile ecosystem.
PD-L1 and tumor-infiltrating CD8+ lymphocytes are correlated with clinical characteristics in pediatric and adolescent pituitary adenomas
Authors: Shi Mengwu , Song Yifu , Zhang Yaochuan , Li Longjie , Yu Juanhan , Hou Ana , Han Sheng
Published: June 2023

Objective

To investigate the levels of tumor-infiltrating CD8+ lymphocytes (CD8+ TILs) and the expression of programmed cell death receptor ligand 1 (PD-L1) in the tumor microenvironment (TME) of pediatric and adolescent pituitary adenomas (PAPAs) and analyze the correlation between their levels and the clinical characteristics.

Methods

A series of 43 PAPAs cases were enrolled over a period of 5 years. To compare the TME of PAPAs and adult PAs, 43 PAPAs cases were matched with 60 adult PAs cases (30 cases were between 20 and 40 years old, and 30 cases were older than 40 years) for main clinical characteristics. The expression of immune markers in PAPAs was detected by immunohistochemistry, and their correlation with the clinical outcomes was analyzed using statistical methods.

Results

In the PAPAs group, CD8+ TILs level was significantly lower (3.4 (5.7) vs. 6.1 (8.5), p = 0.001), and PD-L1 expression (0.040 (0.022) vs. 0.024 (0.024), p < 0.0001) was significantly higher as compared with the older group. The level of CD8+ TILs was negatively correlated with the expression of PD-L1 (r = −0.312, p = 0.042). Moreover, CD8+ TILs and PD-L1 levels were associated with Hardy (CD8, p = 0.014; PD-L1, p = 0.018) and Knosp (CD8, p = 0.02; PD-L1, p = 0.017) classification. CD8+ TILs level was associated with high-risk adenomas (p = 0.015), and it was associated with the recurrence of PAPAs (HR = 0.047, 95% CI 0.003–0.632, p = 0.021).

Conclusion

Compared with the TME in adult PAs, the TME in PAPAs was found to express a significantly altered level of CD8+ TILs and PD-L1. In PAPAs, CD8+ TILs and PD-L1 levels were associated with clinical characteristics.
The prolonged impact of COVID-19 on symptoms, health-related quality of life, fatigue and mental well-being: a cross-sectional study
Authors: Brus Iris M. , Spronk Inge , Haagsma Juanita A. , de Groot Annemieke , Tieleman Peter , Biere-Rafi Sara , Polinder Suzanne
Published: June 2023

Background

A subset of patients experience persisting symptoms after an acute COVID-19 infection, referred to as “post COVID-19 condition”. This cross-sectional study aimed to compare symptoms, health-related quality of life (HRQoL), fatigue, mental well-being, and determinants of diminished HRQoL, between patients with post COVID-19 condition categorized by time since acute infection.

Methods

We performed an online survey and analyzed responses of 10,194 adult respondents with a confirmed or suspected COVID-19 infection, who experienced persisting symptoms ≥3 months after the initial infection. The most debilitating symptoms and health outcomes were studied separately for respondents 3–6, 7–9, 10–12, 13–18, 19–24, and >24 months after acute infection.

Results

At each time period, fatigue, sensory-processing problems, and concentration problems were the most debilitating symptoms reported by respondents, although the proportion of respondents who reported these symptoms differed significantly between time periods. Respondents 3–6 months post-acute infection had the lowest HRQoL (median EQ-5D utility score: 0.59), the highest fatigue level (median score: 110.0) and the highest proportion with a likely depressive disorder (32.4%), whereas respondents 13–18 months post-infection had the highest HRQoL (0.65), the lowest fatigue level (106.0), and the second lowest proportion with a likely depressive disorder (25.0%) (p = 0.000–0.007). Compared to those 13–18 and 19–24 months post-infection, respondents >24 months post-infection had a slightly lower HRQoL (0.60), lower fatigue level (108.0), and lower proportion with a likely depressive disorder (29.2%), although only the differences in HRQoL were statistically significant (p = 0.001–0.010). Younger age, female gender, lower level of education, not having paid work before COVID-19, comorbidity, and not being vaccinated, seemed to be associated with lower HRQoL.

Conclusion

Regardless of time since infection, respondents considered fatigue, sensory processing problems and concentration problems the most debilitating symptoms. They experienced a low HRQoL and severe fatigue, even more than two years after acute COVID-19 infection. Respondents 3–6 months post-infection had the worst health outcomes, whereas respondents 13–18 months post-infection had the best outcomes, indicating that, at least for a subgroup of patients, health status may improve over time.