bluuebunny/crossref_metadata_2025 huggingface dataset:
ISI YALITIMLI HARÇ ÜRETİMİNDE BAZI ETKEN PARAMETRELERİN SPSS YÖNTEMİ İLE İNCELENMESİ
Authors: ŞAPCI Nükhet , SİVRİ Mustafa
Published: March 2024

Son yıllarda enerji tasarruflu binalar ekonomik ve ekolojik özellikleri nedeniyle önem kazanmıştır. Ayrıca deprem felaketlerinin yaşamamızda oluşturduğu ciddi hasarlar nedeniyle, çimentolu harçlarda hafif agrega kullanımının önemi daha iyi anlaşılmıştır. Özellikle gözenekli hafif agregaların ısı yalıtımlı harçların geliştirilmesinde önemli bir hammadde olduğu görülmüştür. Kompozit formdaki bu harçların termal özelliğini gösteren en önemli etki ısı iletkenlik katsayılarının tespit edilmesidir. Bu makale çalışmasında 3 farklı kökende hafif agrega ana hammadde olarak kullanılmıştır. Toplamda polimer katkılı 15 farklı karışım tasarımı yapılmıştır. Elde edilen sıva numunelerinin ısı iletkenlik özellikleri, polimer katkı kullanılmadan üretilen kontrol numuneleri ile kıyaslanmıştır. Deneysel çalışmalarda elde edilen örneklerin TS EN 998-1’e göre T1 ve T2 “Isı Yalıtımlı Harçlar” kategorisinde yer alabileceği tespit edilmiştir. En düşük kuru birim hacim ağırlık 554 kg/m3 ve 0,087 W/mK ısı iletkenlik katsayısı ile Diyatomit agregalı serilerde belirlenmiştir. Ayrıca farklı tasarımlardaki bu harçların, bir duvar kesitinden ısısal konfor performansının incelemesi yapılmıştır. Bu çalışmada birim hacim ağırlık ve ısı iletkenlik katsayısı analizlerinin etkinliklerinin belirlenmesi için SPSS (V26) programı ile sonucu etkileyen parametreler belirlenmiştir.
PHOTOPLETHYSMOGRAPHY BASED BLOOD PRESSURE ESTIMATION USING SYNCHROSQUEEZING TRANSFORM AND DEEP LEARNING
Authors: HEKİM TANÇ Yeşim , ÖZTÜRK Mahmut
Published: March 2024

Cardiovascular diseases are one of the deadliest health problems. Hypertension is the most common reason for cardiovascular diseases. Keeping the blood pressure (BP) level under control is the only way to protect against the deadly results of hypertension. Therefore, monitoring BP regularly makes it possible to detect dangerous conditions in patients with hypertension. With the rapid developments in computers and sensor technologies, it is becoming possible to monitor BP levels continuously by using photoplethysmogram (PPG) signals. This work presents a non-invasive BP prediction method using one channel PPG signal. We employed the Synchrosqueezing Transform to obtain Time-Frequency (TF) images of the PPG signals. The TF images were used to feed a pre-trained deep neural network. We estimated the BP levels inside the 5-second intervals. Our method estimates BP levels with a mean error (ME) of 0.2148 mmHg and -0.0370 mmHg in the systolic and diastolic blood pressure (SBP and DBP) respectively. The ME values of our method are in the applicable levels. The standard deviation (SD) of our method is 5.0642 mmHg for DBP and 10.9904 mmHg for SBP. The upper limit specified by the AAMI is 8 mmHg. Also, our method is coherent with grades A and B according to the BHS standard.
Epidemiology, course and predictors of long-term COVID infection (long COVID): A review
Authors: Tsygankova Anna E. , Gerasimov Andrey N. , Malov Valerii A. , Darvina Olga V. , Volchkova Elena V. , Chulanov Vladimir P.
Published: March 2024

The COVID-19 pandemic has posed a serious challenge to the healthcare system in the 21st century. At present, over 771 million cases have been reported worldwide. Apart from the acute symptoms, many patients experience long-term consequences of the infection, which greatly affect their quality of life. The collection of these long-term effects is called “long COVID.” Therefore, the consequences of COVID-19 must be studied to develop effective strategies for combating them. This review aimed to provide an overview of the history of long COVID and discuss the characteristics of contemporary terminology. This review also presents data on the prevalence of long COVID, primary symptoms, and risk factors and explores potential biomarkers, prognosis, and prospects for subsequent clinical trials.
Analysis of disinfectant use by medical organizations of the Republic of Tatarstan in the context of changes in the epidemiological situation 2019–2022
Authors: Lokotkova Alla I. , Bulycheva Irina A. , Mamkeev Eldar Kh. , Karpenko Luiza G. , Fazulzyanova Ilsiya M. , Sabaeva Farida N. , Toshchev Georgiy A.
Published: March 2024

BACKGROUND: Disinfection is an important aspect of ensuring epidemiological safety in medical organizations, particularly during the COVID-19 pandemic.
AIM: To analyze the disinfectant use in state medical organizations of the Republic of Tatarstan from 2019 to 2022, considering changes in the epidemiological situation related to COVID-19, and provide recommendations based on the analysis.
MATERIALS AND METHODS: Electronic auction data from zakupki.gov.ru were used to analyze disinfectant purchases by state medical organizations in the Republic of Tatarstan from 2019 to 2022. Data analysis involved the application of descriptive statistical methods.
RESULTS: A total of 118 electronic auctions were analyzed. A relationship between the nature of the epidemiological situation and the selection of disinfectants for purchase based on their chemical composition and intended use was identified. Before the pandemic, medical organizations preferred quaternary ammonium compound disinfectants and antibacterial soaps for hand hygiene. During the COVID-19 pandemic, their use of chlorine-based disinfectants, hydrogen peroxide, and alcohol-based hand sanitizers containing 60–69% ethanol increased. As the epidemiological situation stabilized, a discernible shift in preferences toward compound disinfectants was noted. Antiseptics with an alcohol content 70% are increasingly sought after.
CONCLUSIONS: Medical organizations in the Republic of Tatarstan promptly respond to changes in the epidemiological situation by implementing necessary modifications to antiepidemic measures. When developing procurement strategies, not only the requirements of sanitary legislation but also the latest scientific findings in the field of disinfectology must be considered.
Dom Dinis de Portugal: o trovador peregrino/ Dom Dinis of Portugal: The Pilgrim Troubadour
Authors: Cunha Viviane
Published: March 2024

Resumo: Um dos mais profícuos reis de Portugal e um dos grandes trovadores, Dom Dinis foi, além disso, um rei peregrino, que percorreu o Caminho Português a Santiago de Compostela, fato ignorado pelos historiadores, e que Rossi Vairo (2012) trouxe à luz, tema que será aqui abordado. Com ênfase neste último aspecto – rei-peregrino –, estudase neste artigo alguns principais fatos da vida do grande rei e das suas relações com o seu tempo.Palavras-chave: Dom Dinis; peregrinação; Caminho de Santiago; poesia.Abstract: One of the most prolific kings of Portugal and one of the great troubadours, Dom Denis was also, a pilgrim king, who walked the Portuguese Way to Santiago de Compostela, a fact ignored by historians, and which Rossi Vairo (2012) brought to light, which will be discussed here. With emphasis on this last aspect – pilgrim king – this article studies some of the main facts of the life of the great king and his relations with his time.Keywords: King Denis of Portugal; pilgrimage; Camino de Santiago; poetry
Agustina em duas Convocações/ Agustina in Two Calls
Authors: Rita Annabela De Carvalho Vicente
Published: March 2024

Resumo: Este trabalho visa observar o modo como Agustina Bessa-Luís se relaciona com a biografia e a história em Sebastião José (2003) e Fanny Owen (1987). Na Política e nas Letras, são grandes figuras do seu tempo, envoltas em luzes e sombras, mitificadas pelas comunidades, influentes ainda no imaginário nacional; personalidades que Agustina perscruta de um modo singular.Palavras-chave: Agustina Bessa-Luís; Marquês de Pombal; Camilo Castelo Branco; mito; Portugal.Abstract: This work aims to observe how Agustina Bessa-Luís relates to biography and history in Sebastião José (2003) and Fanny Owen (1987). In politics and in literature, they are great figures of their time, shrouded in lights and shadows, mythologized by the communities, still influential in the national imagination; personalities that Agustina scrutinizes in a unique way.Keywords: Agustina Bessa-Luís; Marquis of Pombal; Camilo Castelo Branco; myth; Portugal.
Nota de apresentação
Authors: Leão Isabel Ponce de , Junqueira Renata Soares , Oliveira Silvana Pessôa de
Published: March 2024

Nota de apresentação.
Quatro máscaras e um par de luvas − da enunciação à narração impossível/ Four Masks and a Pair of Gloves - Enunciation and the Impossibility of Narration
Authors: Capela Cláudia
Published: March 2024

Resumo: Este ensaio lê a incerteza e a incongruência dos textos de Agustina Bessa-Luís, atendendo a Joia de família em particular, como mecanismo operativo de verosimilhança. Paralelamente, discutir-se-á a figuração do narrador agustiniano, interventivo, segundo a noção de polimodalidade focal, interessando, sobretudo, perspetivar a focalização restritiva plural por oposição à omnisciência, cuja subversão conduz à ironia enquanto realização técnica nos textos agustinianos.Palavras-chave: incerteza; Joia de família; focalização; ironia.Abstract: This essay intends to read uncertainty in Joia de família and other texts by Agustina Bessa-Luís as a mechanism of reliability in which the subversion of an omniscient narrator and the intervention of multiple restrictive focalizations produce irony.Keywords: uncertainty; Joia de família; focalization; irony.
Thermal stress analysis in pin fin microchannel heat sink
Authors: Janı Mohammad Nazirul Syafiqaiman , Saeid Nawaf
Published: March 2024

The conjugate heat transfer and the thermal stresses produced within a pin-fin microchannel heat sink are investigated numerically. The pin-fin microchannel heat sink is subjected to a constant heat flux from the bottom surface and cooled by water flow through the channel across the pin fins. Rectangular cross-section microchannel incorporating one raw of square pin fins are considered. The water flowing through the microchannel at Reynolds number varies from 200 to 800. The heat sink dissipates constant heat flux in the range of 75-175 kW/m2. The selected materials used for the solid substrate are Copper, Aluminium, Titanium, and Structural steel. The results are presented as contour plots for the temperature, thermal stress, and deformation distribution. It is found that the heat dissipation and the Nusselt number are increased with increasing Reynolds number, increasing the thermal conductivity of the mate-rial but remain constant throughout various heat fluxes. Thermal stresses are increased with decreasing Reynolds number, increasing heat flux, and increasing Youngs’ Modulus of the substrate material. The total deformation is increased with decreasing Reynolds number, in-creasing heat flux, and increasing the thermal expansion coefficient of the substrate material.
Enhancement in air-cooling of lithium-ion battery packs using tapered airflow duct
Authors: Satheesh Vivek K. , Krıshna Navneet , Kushwah Prakhar Singh , Garg Ishan , Raı Sharmista , Hebbar Gurumoorthy S. , Naır Dileep V.
Published: March 2024

Temperature uniformity and peak-temperature reduction of lithium-ion battery packs are critical for adequate battery performance, cycle life, and safety. In air-cooled battery packs that use conventional rectangular ducts for airflow, the insufficient cooling of cells near the duct outlet leads to temperature nonuniformity and a rise in peak temperature. This study proposes a simple method of using a converging, tapered airflow duct to attain temperature uniformity and reduce peak temperature in air-cooled lithium-ion battery packs. The conjugate forced convection heat transfer from the battery pack was investigated using computational fluid dynamics, and the computational model was validated using experimental results for a limiting case. The proposed converging taper provided to the airflow duct reduced the peak temperature rise and improved the temperature uniformity of the batteries. For the conventional duct, the boundary layer development and the increase in air temperature downstream resulted in hotspots on cells near the outlet. In contrast, for the proposed tapered duct, the flow velocity increased downstream, resulting in improved heat dissipation from the cells near the outlet. Furthermore, the study investigated the effects of taper angle, inlet velocity, and heat generation rate on the flow and thermal fields. Notably, with the increase in taper angle, owing to the increase in turbulent heat transfer near the exit, the location of peak temperature shifted from the exit region to the central region of the battery pack. The taper-induced improvement in cooling was evident over the entire range of inlet velocities and heat generation rates investigated in the study. The peak temperature rise and maximum temperature difference of the battery pack were reduced by up to 20% and 19%, respectively. The proposed method, being effective and simple, could find its application in the cooling arrangements for battery packs in electric vehicles.
A New Two-Parameters Lindley-Frailty Model: Censored and Uncensored Schemes under Different Baseline Models: Applications, Assessments, Censored and Uncensored Validation Testing
Authors: Teghri Samia , Goual Hafida , Loubna Hamami , Butt Nadeem Shafique , Khedr Abdelrahman M. , Yousof Haitham M. , Ibrahim Mohamed , Salem Moustafa
Published: March 2024

Classical survival models assume homogeneity among the population of individuals who are susceptible to the event of interest. However, in many practical circumstances, there is a certain amount of unobserved heterogeneity that can be caused by a variety of sources, such as environmental or genetic factors. If the heterogeneity is ignored, many issues could arise, including an overestimation of the hazard rate and inaccurate estimates of the regression coefficients. Frailty models are usually used to model the heterogeneity among individuals. In this paper, we propose a novel univariate frailty model. The frailty variable is assumed to follow the Two Parameter Lindley distribution. The maximum likelihood method is used to estimate the model parameters. The baseline hazard functions are assumed to follow Weibull, Exponential, Gompertz, and Pareto distributions, and a simulation study is performed under this assumption. We examine the characteristics of the distribution and assess its performance compared to other distributions that are frequently applied in frailty modeling by using both Nikulin-Rao-Robson and Bagdonavicius-Nikulin goodness-of-fit tests to determine the adequacy of the model. We analyze a fresh medical dataset collected from an emergency hospital in Algeria to evaluate the effectiveness and applicability of the proposed model.
PENGARUH PROMOSI TERHADAP SIKAP PASIEN RS PKU MUHAMMADIYAH BANTUL
Authors: Susanto Susanto , Astuti Sari Dwi
Published: March 2024

The mushrooming hospitals in Bantul had forced PKU Muhammadiyah hospital to conduct promotions. A promotion will be very useful to provide information to the society about the service excellence offered by a hospital in order that it becomes the society’s preference when they seek for medical and health treatment. This research was a descriptive quantitative one using cross sectional
approach. The population included all outpatients, and the sample was confined to 90 patients. Meanwhile, the analytical tool was the multiple linier regression. This research found a regression equation of Y = 0.225 X1 + 0.267X3 + 0.338X4 + e. The coefficient of determination (R2) was 0.649, which explained that the involvement of promotion influenced patients’ attitude as much as 64.9%. The score of F count was 42.159 with F significance of 0.000 and 95% confidence. For the mean time, the influence of promotional activities to the attitude of the patients of PKU MuhammadiyahBantul Hospital comprised advertising (2.129, p = 0.036), direct marketing (2.774, p = 0.007), and public relation (3.657, p= 0.000). Meanwhile, the variable personal selling did not influence the patient’s attitude (1.074, p = 0.286). To sum up, the factors in promotion mix influencing the attitude of the patients in PKU MuhammadiyahBantul Hospital are advertising, direct marketing, and public relation.
PELAKSANAAN KEBIJAKAN DAN PENILAIAN PENGGUNAAN APD (ALAT PELINDUNG DIRI) OLEH DOKTER DAN BIDAN DI RUANG BERSALIN DAN NIFAS RSU PKU MUHAMMADIYAH YOGYAKARTA UNIT I TAHUN 2014/2015
Authors: Supiana Nia , Supriyatiningsih Supriyatiningsih
Published: March 2024

Background: Hospital is a place for taking care of the patients where there are many kinds of disease there. Disease caused by infection is one of disease that can be found in hospital. It can be the mild one or the severe one. Therefore, it can spread from one patient to the other patients. Besides that, the workers also can be infected since their job required them to having a contact with the infection agent. The General hospital of PKU Muhammadiyah Yogyakarta Unit 1 has formed the Komite Pencegahan dan Pengendalian Infeksi (KPPI) or Committee of Prevention and Restraint of Infection since 2012, this committee has made a policy related to universal precautions which giving protection to medical staff, patients, and patients’ families.

Methods: In collecting the data, this research used mixed method with concurrent triangulation strategy design and cross-sectional approach. The population of this research is doctors in delivery and postpartum room and the members of KPPI. The total of the population is 30 people. In analyzing the data, the writer used logistic regression. The resources were taken from some related books, journals, articles, and research from several media.

Results and Discussion: The result of this research showed that the degree of compliance of doctors and midwives in using PPE (Personal Protective Equipment) in postpartum room (92.9%) was higher than the using of PPE in the delivery room (76.9%). This implementation/compliance is influenced by disposition factors/attitude (ρ = 0.000 <0.05) and the structure of bureaucracy (ρ 0,000 <0.05), while the variable of communication (ρ=0,164 > 0,05) and resource (ρ=0,431 > 0,05) do not influence on the implementation of the use of PPE.

Conclusions and Recommendations: The implementation of the use of PPE in the delivery and postpartum room is still not performing well and the evaluation process was still not optimal. The hospital is expected to improve the supervision of the head room. Moreover, the implementation of SOP (Standard Operational Procedure) on the universal Guidelines for Vigilance Implementation should be conducted especially the use of PPE in delivery and postpartum room.
La memoria como política educativa. Decisiones y tensiones en los orígenes del Programa Nacional Educación y Memoria en Argentina (2005-2007)
Authors: Santos Ibáñez Juliana
Published: March 2024

El objetivo de este artículo es presentar un análisis del Programa Nacional Educación y Memoria como política pública implementada en Argentina para la transmisión del pasado reciente de terrorismo de Estado en el ámbito educativo. A la luz de los debates abiertos en el campo de estudios de la memoria social y de las particularidades de esta política, se reponen cuatro tensiones observadas en su implementación: la conformación del equipo de trabajo, la tensión entre institucionalidad y militancia, la tensión entre políticas públicas de memoria y sociedad civil, y los debates sobre la representación. Se trata de un análisis sistemático sobre la etapa originaria de una política central dentro del universo de políticas reparatorias en Argentina que no cuenta con antecedentes en el campo, y que adopta una perspectiva teórico-metodológica para pensar al Estado como un actor complejo inmerso dentro de las disputas por el sentido del pasado.
Pérdidas monetarias en la producciónde vehículos en México por COVID-19
Authors: Castillo Rodríguez Jesús
Published: March 2024

México desempeña un papel importante a nivel mundial en cuanto a la fabricación de automóviles, y no fue sino a partir de la pandemia por COVID-19 que la industria automotriz se vio sacudida por las medidas sanitarias, al suspender su actividad productiva por no ser un sector prioritario. La pregunta central de esta investigación gira en torno a cuánto vale la pérdida en términos monetarios la suspensión de la fabricación de vehículos y camiones ligeros por la crisis económica causada por la COVID-19. La metodología empleada se basa en el uso de una regresión econométrica múltiple con una variable cualitativa binaria de unos y ceros para capturar el efecto de la COVID-19 en la producción de vehículos, donde los resultados preliminares arrojan pérdidas millonarias de ocho cifras.
A criança em sofrimento psíquico na Rede de Atenção Primária à Saúde em município gaúcho: reflexões a partir de um usuário-guia
Authors: Gallina Bruna Fátima , Pulga Vanderléia Laodete , Schneider Fabiana
Published: March 2024

O estudo teve como objetivo problematizar as práticas de cuidado desde o itinerário terapêutico de uma criança como usuária-guia. Trata-se de uma pesquisa-intervenção de caráter qualitativo transcorrida no período de abril a dezembro de 2022 em uma Estratégia Saúde da Família (ESF), onde realizou-se entrevistas abertas individuais e grupais com usuários, trabalhadores da saúde e da escola onde a criança estuda, a fim de compreender os modos de cuidado instituídos na rede de atenção municipal diante do sofrimento psíquico infantil. A análise de conteúdo se deu a partir da leitura hermenêutica das narrativas entrelaçando-as ao referencial teórico da Psicanálise. Evidenciou-se o uso do usuário-guia como potente estratégia de cuidado e de reconhecimento subjetivo e no fortalecimento da intersetorialidade. Destaca-se, no trabalho com a infância, a importância do encontro inter-humano no cuidado para a sustentação de intervenções pautadas na escuta da singularidade e subjetividade das crianças e familiares.
 
Palavras-chave: Infância; Saúde Mental; Colaboração Intersetorial; Psicanálise; Atenção Primária à Saúde.
Роль педагогических сетевых сообществ в привлечении внимания учащихся
Authors: Кузнецова Н.В. , Козлов О.А.
Published: March 2024

В статье освещена тема важности педагогических сетевых сообществ. Их ценность в цифровом пространстве. Проанализировано современное мышление учащихся и их способность к восприятию информации. Рассмотрены особенности концентрации и удержания вни.
Оценка эффективности экспериментальной работы по обучению практическому вождению боевых машин курсантами ВУЗов Росгвардии с применением современных технических средств обучения
Authors: Тарасов А.Н.
Published: March 2024

В статье показан рост качества знаний и устойчивость навыков владения боевой техникой у курсантов экспериментальной группы, использующих разработанную педагогическую технологию формирования навыков вождения боевых машин у курсантов военных институтов войск национальной гвардии с применением технических средств обучения.
Классификация глаголов ощущения в «Словаре русских говоров Приамурья»
Authors: Фан Х.
Published: March 2024

Статья посвящена описанию глаголов ощущения в русских говорах Приамурья. Предлагается классификация глагольных лексем и фразеологизмов, зафиксированных в «Словаре русских говоров Приамурья», в соответствии с типами ощущения: болевое, естественное ощущение (общее самочувствие человека) и температурное ощущение; выделены синонимические ряды. Материал показал преобладание глаголов с семантикой болезненных ощущений и усталости.
Будущее: этические аспекты
Authors: Зимбули А.Е.
Published: March 2024

Можно всматриваться в смысловое пространство БУДУЩЕГО с разных сторон, через разные «окуляры»: историко-теологически, историко-философски, историко-психологически, культурно-аксиологически, психотерапевтически, да мало ли ещѐ как. В предлагаемом тексте автор предпочитает придерживаться такого конкретного взгляда, который даст возможность обозреть многомерную матрицу будущего, включаемого в культуру: взгляд нравственноценностный. Который важен безотносительно к тому, верят ли люди в богов или в коммунизм, жили они три тысячи лет назад или живут нынче, на каких языках они говорят и с каким гендером себя идентифицируют. Ведь такие сюжеты, как ЧЕСТНО / ЛЖИВО, ГУМАННО / ЖЕСТОКО, СПРАВЕДЛИВО / НЕСПРАВЕДЛИВО, ОТВЕТСТВЕННО / БЕЗОТВЕТСТВЕННО, СВОБОДНО / ВЫНУЖДЕННО, ДОСТОЙНО / ПОДЛО. Для подобного универсального взгляда удобным будет отталкиваться от следующей обобщѐнной структуры: СУБЪЕКТ, АДРЕСАТ, СОДЕРЖАНИЕ, ПЕРЕЖИВАНИЕ, ПОНИМАНИЕ, ПОВЕДЕНИЕ. Предлагается краткий обзор каждого из указанных компонентов, и ещѐ более краткие выводы: Мы ответственны за своѐ будущее. Что создадим – в том и будем жить. Плюс – оставим преемникам.
Анализ развития инновационно активных компаний сектора аппаратного обеспечения и оборудования
Authors: Дубинина М.Г.
Published: March 2024

В статье рассмотрена динамика основных экономических показателей наиболее инновационно активных компаний мира сектора аппаратного обеспечения и оборудования (Technology Hardware & Equipment, THE), а также подсектора производства полупроводников. Рассмотрена региональная структура продаж, факторы, способствующие росту этого сектора и тормозящие его развитие.
Обеспечение безопасности информационных технологий предприятий при помощи систем многофакторной аутентификации
Authors: Ларин С.Н.
Published: March 2024

В современных условиях развитие мировой экономики сопровождается стремительным ростом объемов и форматов представления информации, необходимой предприятиям для ведения своей производственной деятельности. Однако, вместе с этим возникают проблемы обеспечения безопасности, поскольку происходит увеличение числа кибератак на информационные системы предприятий всех сфер деятельности. Это приводит к самым снижению эффективности их функционирования и повышению рисков наступления возможного ущерба. Один из подходов к решению этой проблемы связан с внедрением технологий многофакторной аутентификации при организации доступа пользователей к информации. Описаны эффекты, генерируемые системами многофакторной аутентификации пользователей в плане обеспечения информационной безопасности производственной деятельности предприятий. Внедрение систем многофакторной аутентификации позволит обеспечить информационную безопасность предприятий.
The Moroccan caftan is an inspiration for contemporary Iraqi women's clothing
Authors: Alzubeidi A.N.
Published: March 2024

Марокканский кафтан получил широкий резонанс и большой интерес на международных показах мод, а дома моды спешат представить обновленные и вдохновленные модели марокканского кафтана. Традиционна для него и работа с графиками базовой выкройки кафтана, с помощью которых можно вывести и создать обновленные модели кафтана, а также изучение основного силуэта кафтана с целью узнать его изменение под влияние современной моды и смогла ли она противостоять этим изменениям и повлияло ли влияние кафтана на гардероб других людей, например, Ирак, который является источником. Он богат культурой и искусством и известен своей великой наследие и разнообразие народной и традиционной одежды в разных регионах, в зависимости от расы, религии и региона, которые различались между болотами, равнинами и горными регионами.
Towards effects from stent implantation into coronary bifurcation stenosis: experiment and simulation
Authors: Gaifutdinov R. A. , Kuyanova Yu. O. , Khelimsky D. A. , Krestyaninov O. V. , Tulupov A. A. , Parshin D. V.
Published: March 2024

Coronary artery disease is a widespread cause of death and disability in the population. Angioplasty of the coronary arteries is one of the most common methods of eliminating the cause of ischemia – stenosis of the coronary arteries. As a result of stent installation, a change in the angle of vascular bifurcation occurs usually, as well as a redistribution of volumetric blood flow in the coronary artery system. Considering the high variability of the branching angioarchitecture of these arteries, as well as the structure of their environment, the problem of predicting the specific redistribution of blood flow in these arteries remains unsolved; the main ways of its implementation are computational and experimental hemodynamics. Material and methods. This paper uses an experimental approach to explore the effect of stent placement in a model of coronary artery stenosis, and also provides an analysis of the current level of awareness of the scientific community on this issue. Results and discussion. The experiment showed that the throughput of the model increases by 14 % compared to the model with stenosis, and the redistribution of flows in the model depends not on diameters but on the anatomy of a particular vascular network. The data of the performed mathematical modeling are generally consistent with the results of the experiment before stent installation, when the coronary tree consists of several load-bearing branches, but have quantitative differences for the distal branches of the coronary artery model in the presence of an installed stent. Conclusions. The results of the work can be used to accumulate an experimental data array on the restructuring of blood flow during angioplasty, and can also be used to verify the numerical hemodynamics of the coronary arteries during the virtual installation of a stent in them to resolve stenosis.
Multiple sclerosis: modern diagnostic markers and prognostic factors of disease progression
Authors: Prokaeva A. I. , Arkhipov I. E. , Dorchinets E. E. , Korobko D. S. , Malkova N. A.
Published: March 2024

Multiple sclerosis (MS) is one of the most common causes of disability in young people of working age. The prevalence of this disease has increased significantly in recent years and today amounts to more than 2 900 000 people worldwide. The transition from relapsing-remitting MS to secondary progressive MS is observed in 25 % of cases within 10 years the disease duration, and with further time the proportion of patients with secondary progressive MS increases. Despite the importance of preventing patient disability, today the diagnosis of secondary progressive MS is established retrospectively, which makes the issue of identifying early markers of disease progression extremely relevant. The most promising diagnostic markers allow the differentiation of progressive MS with a sensitivity of up to 87 % and a specificity of up to 90 %. This review will consider the most promising clinical, instrumental and biological signs of early progression of MS.
Remodeling of extracranial veins and venous-arterial imbalance in extrinsic stenosis and hypoplasia of the internal jugular veins
Authors: Semenov S. E. , Bondarchuk D. V. , Malkov I. N. , Shatokhina M. G.
Published: March 2024

The aim of the study was to compare hemodynamic parameters, the sequence of remodeling of the jugular and extrajugular outflow tracts of cerebral venous circulation in extrinsic stenosis and hypoplasia of the internal jugular vein (IJV). Material and methods. Groups with external compression and IJV stenosis (n = 50), with IJV hypoplasia (n = 27), and after IJV ligation/resection (n = 6) as a model of IJV occlusion with a minimal cerebral venous insufficiency and venous encephalopathy and control group (n = 31) were compared. All patients underwent a neurological examination, ultrasound duplex scanning of the IJV (J2 and at the level of stenosis), common carotid and vertebral artery (V2), 2DToF or 3DToF magnetic resonance venography of the neck veins. The degree of stenosis of the IJV, the crosssectional area and the time average blood flow velocity, the calculated indicator of the venous-arterial balance (VAB) were determined according to the modified formula. Results and discussion. In the group of external compression of the IJV, stenosis averaged 64.52 %. The area of the IJV at the site of stenosis was 6 times, and at the standard place (J2) – 3 times less than the area of the opposite IJV. The hypoplastic IJV throughout its entire length (from J1 to J3) had the same area (0.21 ± 0.12 cm2 ), smooth contours, without local expansions or narrowings. A very low blood flow velocity (10.2 ± 11.67 cm/s) is characteristic for stenosis, in contrast to the normal velocity in the hypoplastic vein and in the control group. The blood flow velocity in the contralateral IJV with external stenosis does not differ from normal, but it is increased with hypoplasia (34.62 ± 12.23 cm/s). With MR venography, it is possible to detect a stenosing factor, symptoms of a filling defect, a decrease or loss of a blood flow signal, and an assessment of the overall picture of remodeling of the venous network of the neck. A decrease in the IJV area on the side of the lesion/anomaly corresponds to negative remodeling, while an expansion of the opposite IJV corresponds to positive remodeling. If the obstruction persists, the homolateral, then the contralateral external jugular vein expands, then the vertebral veins and plexuses, spinal epidural veins, anterior jugular and posterior cervical veins expand too. The magnitude of the IJV on the side of the anomaly/pathology with hypoplasia did not differ from the value with stenosis (9 %), but was slightly less than on the opposite IJV (53.39 ± 13.40 and 67.24 ± 18.02 %, respectively, p < 0.06) and significantly less compared to the control (24.16 ± 8.06 % on the left and 33.15 ± 8.27 % on the right, p < 0.0001), which makes this indicator a good additional criterion for outflow abnormality according to the IJV of one side.
Indicators of cerebral venous drainage with non-thrombotic disorders in extracranial veins
Authors: Semenov S. E. , Bondarchuk D. V. , Kokov A. N. , Shatokhina M. G.
Published: March 2024

The growing number of studies on cerebral venous circulation disorders associated with extrinsic stenosis of the internal jugular veins, as well as attempts to surgically influence the restoration of blood flow, are an indicator of the importance of this problem. Studies show that extracranial outflow disorders are associated with a wide range of neurological clinical manifestations and may contribute to the development of congestive intracranial hypertension. Anatomical variants of the development of the extracranial venous system, constitutional insufficiency and stenosis often play similar roles in the development of disorders of the cerebral venous outflow, but differ parametrically. There are no standard diagnostic criteria for differential diagnosis, normal and pathological parameters are contradictory, and the diagnosis largely depends on the combined use of imaging techniques. The history of attempts to study disorders of the cerebral venous circulation is quite long, associated with the technical innovations in every period of time. The most non-invasive, accessible and safe tools for diagnosing non-thrombotic lesions and anomalies of the internal jugular veins are currently recognized as ultrasound scanning and MR venography in tandem. Researchers note both local hemodynamic disturbances at the level of stenosis and changes in the overall picture of the venous vascular network of the neck with certain patterns of its remodeling. The pathological significance of the compensatory expansion of nonjugular outflow tracts (vertebral, paraspinal collateral, spinal epidural veins, etc.) is still a controversial issue. MRI and ultrasound combined show a high degree of agreement between the results, which should stimulate further research into the pathophysiology and differentiation of various causes and severity of non-thrombotic lesions of the jugular veins.
Application of a computer vision algorithm to identify foci of demyelination in multiple sclerosis on MRI images
Authors: Tuchinov B. N. , Suvorov V. , Motorin K. O. , Pavlovsky E. N. , Vasilkiv L. M. , Stankevich Yu. A. , Tulupov A. A.
Published: March 2024

The research was aimed at analyzing modern algorithms for diagnosing lesions in multiple sclerosis on MRI images. Multiple sclerosis is a severe disease of the central nervous system and ranks first among the causes of disability in patients of young working age. In connection with the development of computer vision and machine learning technologies, the relevance of using these technologies for medical diagnostics is growing. Such approaches are necessary for the effective development and implementation of diagnostic systems using artificial intelligence. Modern algorithms and models for lesion segmentation were selected and implemented. Material and methods. The paper presents CV features of diagnosing multiple sclerosis on MRI images, existing data sets: ISBI-2015, MSSEG-2016, MSSEG-2021; existing algorithms and models for lesion segmentation: U-Net, nnU-Net, TransUnet, TransBTS, UNETR, Swin UNETR. Results and discussion. The architectures and models of nnU-Net, UNETR, Swin UNETR were trained and compared at ISBI2015 with various parameters and loss functions. Four MRI sequences were used: T2-WI, T2-FLAIR, PD, MPRAGE. Lesion segmentation was approved by certified experienced neuroradiologists. Conclusions. The approaches described in the paper including data processing, model training, and results analysis, focused on the selection and development of high-quality computer vision algorithms for identifying multiple sclerosis lesions in MRI images. Identification and segmentation of demyelination foci is a necessary step for diagnosing the disease, as well as for calculating and interpreting more meaningful indicators of disease severity and progression.
Cytokines in influenza in children (literature review)
Authors: Kazantseva E. D. , Petrova A. G. , Rychkova L. V. , Darenskaya M. A.
Published: March 2024

This literature review was compiled according to the data of search engines PubMed, eLIBRARY.RU, Google Scholar using key words influenza, cytokines, children. The article highlights the participation of pro-inflammatory and antiinflammatory cytokines in the pathogenesis of influenza, compares the cytokine profile in different strains of the virus, with concomitant pathology, as well as attempts to find an answer to the question: “Why are young children more susceptible to this infection?” The article contains information about the creation of express systems for diagnosing cytokine storm in patients with influenza and other acute respiratory viral infections, taking into account a complex of clinical and laboratory data that comes to the aid of a practicing physician. It should be noted that there are different opinions among authors regarding the early markers of severe and complicated influenza in childhood. This information makes the topic of studying the significance of cytokines in influenza in children relevant, but it requires continuation and clarification of knowledge on this issue.
Quality of life as an indicator of connective tissue condition in women with metabolic syndrome without estrogen support
Authors: Krutikov E. S. , Rumyantseva Z. S. , Tribrat N. S. , Zyablitskaya E. Yu. , Demyanova V. B. , Puchkina G. A. , Efremova N. V. , Gorbunov A. A.
Published: March 2024

In modern medicine, the relevance of the problem associated with the aging of the female body is undeniable. Due to the decrease in the intensity of secretion of sex steroids, the addition of metabolic syndrome is accompanied by processes which can worsen women quality of life. Under conditions of hypoestrogenemia, their physical condition suffers, which directly depends on the structure of the connective tissue that forms the basis of the skin, blood vessels, kidneys, bones, joints and ligaments. This literature review presents current data on reversible and irreversible clinical manifestations of climacteric syndrome. Reversible processes are based on changes that can be corrected: vasomotor, psycho-emotional, urogenital, sexual and musculoskeletal. Late manifestations of menopause on the part of metabolic disorders in the connective tissue determine the greatest severity of the course, and therefore represent a serious public health and health problem. The literature review shows in detail the features of the immune regulation of collagen metabolism, the characteristics of changes in bone modeling markers under conditions of estrogen deficiency. Clinically proven efficacy of phytoestrogens in menopausal disorders and metabolic disorders in women. This review shows the mechanism for reducing vasomotor symptoms, slowing down the process of bone tissue destruction in patients under the influence of this group of drugs. In addition, phytoestrogens provide the correction of lipid metabolism, thereby depressing atherogenesis and promoting prevention of cardiovascular complications. It is necessary to develop a strategy to normalize the vital functions of perimenopausal patients with symptoms of menopause with the introduction into clinical practice of measures to maintain the quality of life of women.
New derivatives of quinazolinone as an object in the search for substances that exhibit a multi-target effect
Authors: Starikova A. A. , Tsibizova A. A. , Zolotareva N. V. , Merezhkina D. V. , Ozerov A. A. , Samotrueva M. A.
Published: March 2024

Due to the rapid growth in the number of patients with diabetes in a complicated epidemiological picture, the question of the possibility of exposure of a substance to several targets becomes more important. It is noted that the most common infectious diseases in patients with diabetes mellitus are infections of the respiratory and urinary tract, skin and soft tissues, diabetic foot ulcers, otitis media and periodontal infections. Antimicrobial agents can have both direct and indirect hypoglycemic effects. Quinazolinones belonging to the group of heterocyclic derivatives exhibit a wide range of pharmacological activity. The use of the PASS program for the purpose of computer prediction of pharmacological activity showed a high probability of the hypoglycemic effect of new derivatives. The obtained results motivated the authors to search for the relationship between antimicrobial action and hypoglycemic effect within the general direction of studying the multi-targeting of drug ligands. Analysis of the literature data, as well as own studies of new quinazolinone derivative pharmacological activity make it possible to divide all ligands into functional groups that cause additional binding to the target molecule. The quinazolinone fragment, characterized by the uniqueness of its structure, can be reasonably attributed to multi-target ligands. The triazole cycle and the sulfonamide group can also purposefully bind to the target molecule. A carbamide residue, a fragment of sulfonylurea and an acetamide group, depending on the structure of the substance they are part of, can function both as a specific ligand and as a functional group involved in the stabilization of the intermediate transition state. The results obtained by the authors, as well as other researchers, allow us to formulate an assumption about the relationship between the mechanisms of antimicrobial and hyperglycemic activity.
Psychomodulatory and anxiolytic effects of ACTH(4-7)-Pro-Gly-Pro and ACTH(6-9)-Pro-Gly-Pro against the background of experimental model of thyroid hyperfunction
Authors: Tsibizova A. A. , Sergalieva M. U. , Andreeva L. A. , Bashkina O. A. , Myasoedov N. F. , Samotrueva M. A.
Published: March 2024

The experimental study is devoted to the identification of possible psychomodulatory and anxiolytic effects of ACTH(4- 7)-Pro-Gly-Pro and ACTH(6-9)-Pro-Gly-Pro under conditions of thyroid hyperfunction. Material and methods. The experiment was performed on white male rats, which were divided into groups: I – control; II – rats with hyperthyroidism model, III and IV – animals receiving ACTH(4-7)-Pro-Gly-Pro (Semax) and ACTH(6-9)-Pro-Gly-Pro at doses of 174 and 178 μg/kg/day, respectively, for 21 days against the background of hyperthyroidism. The development of experimental hyperthyroidism in animals was induced by administration of an aqueous solution of potassium iodide at a dose of 75 µg/kg by intragastric gavage, daily for 3 weeks. Behavioural activity was assessed using psychopharmacological tests “Lattice” and “Light-Dark box” in standard modification. Results and discussion. Under conditions of experimental hyperthyroidism in the “Lattice” test, changes in psychomotor behaviour of animals were observed in the form of suppression of orienteering and exploratory activity, namely, a decrease in the number of stands and exploratory “peeks” downwards. In the test “Light-Dark box” against the background of thyroid hyperfunction, an increase in the level of anxiety was observed, manifested in a decrease in the time spent in the light compartment, the number of transitions between compartments and racks, as well as an increase in the number of assessments of “risk” – “looking out” of the compartment. The studied substances ACTH(4-7)-Pro-Gly-Pro and ACTH(6-9)-Pro-Gly-Pro in conditions of experimental hyperthyroidism promoted the correction of the above-mentioned behavioural disorders, eliminating the anxiety-depressive state of laboratory animals. Conclusions. When studying the effect of ACTH(4-7)-Pro-Gly-Pro and ACTH(6-9)-Pro-Gly-Pro substances under conditions of experimental hyperthyroidism on behavioural activity of white rats in the tests “Lattice” and “Light-Dark box” it was revealed that the studied peptide compounds exhibit psychomodulatory and anxiolytic effects, correcting behavioural reactions.
Weed Flora Composition in Upland Direct Seeded Rice in Brahmaputra River Ecotones and Edges in Majuli District, Assam
Authors: Borah Rashmi Rekha , Gogoi Animesh , Barua Iswar Ch.
Published: March 2024

Background: The River Brahmaputra is one of the largest braided rivers in the world, where the island and bars (“Chapories”) are formed almost annually by erosion and deposition, which are good agricultural lands, as most of the depositions are extremely fertile and possess ready water source in close proximity. With an aim to depict the weed vegetation pattern in upland direct seeded rice ecosystem in such an ecotone zone, Chapories of Majuli district were surveyed during 2021 and 2022. Methods: One square meter quadrates were plotted in between 20 to 65 days after sowing (before flowering) of rice to study the weed status in the critical period of crop weed competition in four locations. Result: Study recorded altogether 55 species of weedy nature in four locations with as many as 39 broadleaved species belonging to 25 families, 3 sedges and 13 grasses, which represented a great diversity with several unusual species unique to chapori areas. Isolation of location - 4 by water channel has contributed in increasing dissimilarity with respect to weed flora, though river water might have had great role in distribution of weeds especially the stubble borne perennial species. The cumulative IVI of grass species was also 30.4 per cent higher in this isolated location than the non-grass species, unlike the locations that had land connectivity with shore areas.
Assessment of Recreational Potential Dendrological Collections of the Federal Scientific Centre of Agroecology of the Russian Academy of Sciences
Authors: Vishnyakova V.V. , Belyaev A.I. , Kalmykova E.V.
Published: March 2024

Background: Dendrological collections and arboretums, being an integral part of the urban landscape, significant elements of its natural and ecological framework, as a rule, also perform recreational functions. The purpose of the study was to assess the recreational potential of dendrological collections and forest plantations of the Federal Scientific Center for Agroecology of the Russian Academy of Sciences for the formation of a program for the renovation of objects as significant elements of the natural-ecological framework of urbanized territories. Methods: The objects of the study are the dendrological collections of the Federal Scientific Center for Agroecology of the Russian Academy of Sciences, which are located in the cities of Volgograd and Kamyshin, Volgograd region. A comprehensive assessment of objects was carried out according to a system of indicators that determine the qualitative characteristics of recreational potential, for each of which coefficients were calculated: CA- Attractiveness coefficient, CC- Comfort coefficient, CR- Resistance to recreational loads coefficient. Result: Analysis of the spatial distribution of assessment results makes it possible to use research materials to develop a targeted program of measures to increase the sustainability of ecosystems.