bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigating the relationship between health literacy and preconceptual care components in pregnancy: A Cross Sectional Study
Authors: Sajjadian Fatemeh , Amiri-Farahani Leila , Haghani Shima , Pezaro Sally
Published: August 2023

Background and Aim: Preconceptual care aiming to improve health is influenced by various factors including health literacy. Considering the importance and necessity of high quality preconceptual care, this study aimed to determine the relationship between health literacy and receiving components of preconceptual care prior to pregnancy.
Methods: This cross-sectional study included 693 participants with pregnancies of less than 14 weeks gestation referred to health centers and gynecologists in Shiraz city, Iran. Multi-stage sampling was done from May 2021 to February 2022 in 18 comprehensive urban health centers and 20 gynecology offices via proportional allocation method. The data collection tool comprised a questionnaire consisting of 3 parts: 1) individual and fertility characteristics, 2) information related to the components of preconceptual care and 3) health literacy for Iranian adults. This was completed by individual participants via the self-reporting method.
Results: The majority of participants in the study were between 30 and 34 years old. They were also women with a university education, predominantly working as housewives. The mean health literacy of participants was 76.81%. Health literacy obtained the highest mean score in the dimension of ‘understanding’ and the lowest mean score in the dimension of ‘access’. The frequency of preconceptual counseling, folic acid supplement consumption, exercise, blood testing, dental visits, genetic counseling, Pap smear testing and rubella, diphtheria, and hepatitis vaccinations prior to pregnancy was 66.8%, 53.8%, 45.6%, 71.86%, 44.44%, 12%, 53.4%, 10.83%, respectively. Many (> 64%) received preconceptual care at specialist gynecology offices. Results demonstrated that health literacy had a statistically significant relationship with preconceptual care, folic acid consumption, exercise and dental care, (p < 0.001), along with blood testing and Pap smear testing (p < 0.05).
Conclusion: Overall, our results demonstrate that despite health literacy being optimal, uptakes of some components of PCC are low. As such, it will be important to further raise awareness of the importance of PCC for people prior to pregnancy as a priority in health promotion and education.
Combined laparoscopic pyeloplasty and suctioning ureteral access sheath assisted flexible ureteroscopy in the treatment of ureteropelvic junction obstruction coexisting with renal calculi: A multi-center retrospective observational study
Authors: mi yang , Kang Zhiqin , Wang Jingyu , Yan Liang , zhang jun
Published: August 2023

Background Ureteropelvic junction obstruction (UPJO) is a common obstructive disease of the urinary tract. It is very common for UPJO patients to have coexistent renal calculi. The main aim of therapy is the relief of the obstruction and the removal of the stones at the same time. Methods This retrospective study included 110 patients diagnosed with the UPJO coexisting with multiple renal calculi at the Shanxi Bethune Hospital and the First Hospital of Shanxi Medical University between March 2016 and January 2022. Patients were divided according to the different methods of dealing with UPJO and renal calculi. In group A, patients received traditional open pyeloplasty and pyelolithotomy. In group B, patients received percutaneous nephrolithotomy first and then received laparoscopic pyeloplasty. In group C, patients received flexible cystoscopy to extract stones and then laparoscopic pyeloplasty. In group D, patients received vacuum suction access sheath-assisted flexible ureteroscopy and underwent laparoscopic pyeloplasty. The stones were smashed using a holmium laser. The success rate of pyeloplasty, stone clearance rate, operation time, bleeding amount, complication occurrence rate, post-surgical pain, length of stay, and hospitalization cost were compared between groups. The follow-up period was at least 2 years. Results By using flexible ureteroscopy and a vacuum suction urethral access sheath, the renal stone clearance rate was significantly increased, and the complication occurrence rate and the operation time were significantly reduced in the UPJO patients coexisting with multiple renal calculi. Conclusions Laparoscopic pyeloplasty combined with flexible ureteroscopy and a vacuum suction urethral access sheath is safe and effective in dealing with UPJO in patients complicated by renal caliceal stones. Trial registration Retrospectively registered
Gut microbiota alterations are associated with functional outcomes in patients of acute ischemic stroke with non-alcoholic fatty liver disease
Authors: Yu Gaojie , Chen Qionglei , Chen Jiaxin , Liao Xiaolan , Xie Huijia , Zhao Yiting , Liu Jiaming , Sun Jing , Chen Songfang
Published: August 2023

Background
Non-alcoholic fatty liver disease (NAFLD) is a risk factor for adverse prognosis of acute ischemic stroke (AIS) and a common comorbidity in patients with AIS. However, the mechanisms by which NAFLD increases the risk of the adverse prognosis remain unknown. This study explored the changes in gut microbiota of AIS patients with NAFLD to expand the understandings of their mechanisms from the perspective of gut microbiota.
Methods
Patients were recruited and divided into 2 groups comprising 64 patients with AIS and NAFLD and 85 patients with AIS but without NAFLD. The stool samples and clinical information were collected. 16s rRNA sequencing was used to analyze the composition of gut microbiota. The patients were followed-up at 3 months post-stroke. The adverse outcome was assessed by modified Rankin Scale. The changes in microbial composition and key bacteria were assessed, and potential microbial marker for predicting risks for the adverse prognosis in AIS patients with NAFLD based on receiver operating characteristic curve was identified.
Results
The relative abundance of Dorea, Dialister, Intestinibacter, Flavonifractor significantly decreased in NAFLD group, while the relative abundance of Enorma significantly increased in NAFLD group. Dorea was identified as the potential microbial marker for predicting the risk of adverse prognosis in AIS patients with NAFLD (area under the curve > 0.600).
Conclusions
This study demonstrated comprehensively gut microbiota characteristics in AIS patients with NAFLD, screened out crucial microbe related to adverse prognosis, and identified the potential microbial marker for predicting the risk of AIS patients with NAFLD.
Molecular regulation of volatile organic compounds accumulation in tomato leaf by different nitrogen treatments
Authors: gao hongdou , Xu ru , Du zhijie , Ye Huilan , Tian Jun , Huang Weiqun , Xu Shuiyong , Xu Fule , Hou Maomao , Zhong Fenglin
Published: August 2023

Tomato plants are easily infected by pests and fungi, which seriously influences the yield and quality. The objective of the present study was to determine the effect of five types of nitrogen (N) treatments on volatile organic compounds (VOCs) by determining the changes in the transcriptome levels of genes related to phenylalanine metabolism, amino acid biosynthesis and plant-pathogen interaction as well as VOCcontent in tomato leaf during growth. The results indicated that low N treatment (1/20 N and 1/5 N) promoted the production of VOCs compared to high N treatment (2 N and 3 N). Low N treatment enhanced the levels of α-pinene, camphene, β-ocimene, D-limonene, caryophyllene, humulene, terpineol, carveol, (E)-2-hexanal, methylis salicylas and cyclobutene. Low N treatment upregulated the differentially expressed genes (DEGs) involved in phenylalanine metabolism and amino acid biosynthesis, which may influence peroxidase, 4-coumarate-CoA ligase, 4-hydroxyphenylpyruvate dioxygenase, caffeoyl-CoA O-methyltransferase, tyrosine aminotransferase, glycine hydroxymethyltransferase, anthranilate phosphoribosyltransferase, branched-chain amino acid aminotransferase, pyruvate kinase (PK), fructose-bisphosphate aldolase, and other enzymes. These enzymes could increase the synthesis of VOCs. Additonally, the DEGs in plant-pathogen interaction have a significant down-regulated trend in 2 N and 3 N compared with 1/20 N, which also responsed the low N could enhance the defense capacity in tomato. In summary, Transcriptome data showed that low N could promote the up-regulation of volatile substances related genes and the increase of VOCs verified the above changes in transcriptome data. Meanwhile, the change of gene in plant-pathogen interaction also demonstrate low N can enhance the defense capacity during tomato growth.
Low CDKN1B expression accompanied by reduced tumor-infiltrating lymphocytes is correlated with an adverse prognosis in breast cancer: machine learning analysis and drug discovery
Authors: Kim Hyung Suk , Noh Yung-Kyun , Min Kyueng-Whan , Kim Dong-Hoon , Son Byoung Kwan , Jung Un Suk , Kwon Mi Jung , Kim Young Seo , Oh Ki-Wook , Pyo Jung Soo
Published: August 2023

The cyclin-dependent kinase inhibitor 1B (CDKN1B) gene encodes the p27Kip1 protein, which plays an important role in cell cycle regulation and cell proliferation, and its role in breast cancer prognosis is controversial. The aim of this study was to analyze the clinicopathological parameters, molecular interactions, and anticancer immune responses in patients with CDKN1B expression. We investigated the clinicopathologic parameters, survival rates, proportions of immune cells, gene sets and prognostic models according to CDKN1B expression in 3,149 breast cancer patients. We performed gene set enrichment analysis (GSEA), in silico cytometry, pathway network analyses, in vitro drug screening and gradient boosting machine (GBM) learning. High CDKN1B expression levels in breast cancer correlated with high lymphocyte infiltration signature scores and increased CD8 + T cells, which were associated with a better prognosis. CDKN1B expression was associated with gene sets for upregulation of T-cell receptor signaling pathways and downregulation of CD8 + T cells. Pathway network analysis showed that CDKN1B was linked directly to positive regulation of the protein catabolic process pathway and indirectly to the T-cell receptor signaling pathway. We found that BMS-345541 was an effective drug that targeted CDKN1B and effectively supressed the growth of breast cancer cells with low CDKN1B expression in drug screening. The GBM model that included CDKN1B expression exhibited improved performance in predicting survival. CDKN1B expression may play an important role in the progression of breast cancer, and targeting CDKN1B may be a potential strategy for the treatment of breast cancer.
Efficacy and safety of stereotactic ablative brachytherapy (SABT) as salvage treatment for sacral region local recurrent rectal cancer: a multicenter retrospective study
Authors: Li Xuemin , Wang Zhe , Xing Chao , Wu Lirong , Wang Hao , Jiang Yuliang , Ji Zhe , Qiu Bin , Sun Haitao , Zhang Kaixian , Wang Ruoyu , Wang Junjie
Published: August 2023

Background:
To investigate the efficacy and safety of stereotactic ablative brachytherapy (SABT) as salvage treatment for sacral region local recurrent rectal cancer (S-LCCR).
Materials and Methods:
Fifty-two patients with S-LCCR after radical resection from January 2016 to December 2020 in four institutes were enrolled in this retrospective study. All patients received 3D-template (3D-PT) assisted SABT. Median tumor volume was 43.2 (range 3.1-178.7) cc. Local control (LC), overall survival (OS), pain relief, and adverse events was recorded and analyzed.
Results:
Median follow-up was 29.3 (range 15.7-42.9) months. Median LC was 24.0 (range 13.5-34.5) months. LC at 1-, 2- and 3-year were 66.7%, 46.9% and 39.1%, respectively. Median OS was 17.7 (range 9.6-25.9) months. OS at 1-, 2- and 3-year were 61.1%, 35.3% and 29.5%, respectively. Univariate analysis suggested that D90＞130Gy (P=0.007) and tumor volume ≤45cc (P=0.007) were positive prognostic factors influencing LC. Pain relief rate was 96.6% (28/29). Rate of adverse events (≥grade 3) was 7.7%.
Conclusion:
SABT may be a feasible and promising salvage treatment for sacral region recurrent rectal cancer after surgery.
Brown blotted root rot of ginger (Zingiber officinale) caused by Musidium stromaticum
Authors: Hayashi Kazusa , Hirooka Yuuri , Oki Tomoka , Shimomoto Yoshifumi , Yano Kazutaka
Published: August 2023

Brown lesions were found on ginger rhizomes in Kochi Prefecture, Japan, leading to the suspicion of an unknown disease. The filamentous fungus isolated at high frequency from the lesions replicated the disease symptoms upon inoculation, confirming it as the causal agent. Through morphological and molecular analyses, this filamentous fungus was identified as Musidium stromaticum. We propose the name “brown blotted root rot” to describe this new disease of ginger. This study is the first to recognized M. stromaticum as a plant pathogen of ginger globally.
Changes of aqueous humor cytokine profiles of patients with high intraocular pressure after PPV for retinal detachment
Authors: Zhu Chenchen , Cheng Yan , Tang Yi , Wu Hong , liu Zaoxia
Published: August 2023

High ocular pressure is one of the early complications after pars plana vitrectomy (PPV), which may cause glaucoma and poor visual prognosis secondary to surgery. It’s essential for the basic mechanism to analyze the relative humor cytokine profiles and clinical factors with intraocular pressure (IOP) after PPV for retinal detachment (RD). In this study, we have collected the aqueous humor of 16 patients with high IOP after PPV and 16 patients with normal IOP after PPV. We qualified 27 cytokines using Luminex multiplex cytokines analysis and compared biomarkers with high IOP group and normal group. In a result, the concentration of VEGF, IL-6, FGF2, and G-CSF upregulated significantly (P < 0.05), while VEGFR2 downregulated significantly (P < 0.05) in high IOP group. IL-6 was positively correlated with high IOP (r = 0.561, P = 0.041). Meanwhile, the concentration of IL-6 (r = 0.543, P = 0.03), IL-5 (r = 0.576, P = 0.019), IL-15 (r = 0.614, P = 0.011), IL-4 (r = 0.517, P = 0.04), ICAM-1 (r = 0.611, P = 0.012) and G-CSF (r = 0.636, P = 0.008) were significantly associated with preoperative PVR classification, and the aqueous humor levels of IL-4 (r = 0.567, P = 0.022), HGF (r = 0.701, P = 0.005), and MCP-1 (r = 0.565, P = 0.035) are significant relative to laser points. Hence, cytokines might potentially be the therapeutic target of high IOP after PPV.
An anti-inflammatory nanoghost for atherosclerosis therapy: a red blood cell based bio-mimetic strategy
Authors: Karami Zahra , Akrami Mohammad , Esfandyari-Manesh Mehdi , Haririan Ismaeil , Nateghi Saeed
Published: August 2023

Inflammation control is becoming a critical strategy for atherosclerosis management, because inflammation is involved in plaque progression. In this regard, a biomimetic strategy using cell membrane-coated nanoparticles has some promising advantages. In the study, a RBC membrane-based nanoghost containing Glyburide (Glibenclamide) was prepared using an extrusion method. The hydrodynamic size and zeta potential of the nanoghost were changed compared to PLGA nanoparticles. In addition, a nanoghost with a diameter and shell size of 125nm and 8.3nm was obtained based on the TEM measurement. The fabricated nanoghost was not only hemocompatible but also was biocompatible. According to RT-PCR assay, the expression levels of inflammatory genes including NLRP3, IL-1β, IL-18 caspase1, 8 and 9 were decreased. In accordance with in vitro anti-inflammation properties, total foam cells, total surface area in tunica intima and population of CD14 + cells were decreased in the rabbit model of atherosclerosis upon nanoghost treatment, compared to positive control. Furthermore, macrophages in aorta sections exhibited M1 to M2 polarization. In general, the development of Glyburide-loaded nanoghost can be considered as a potential therapeutic for controlling the progression and inflammation of atherosclerotic plaque.
WITHDRAWN: Factors influencing the acceptance of wrist-worn wearable devices by the elderly in China
Authors: Cai Min , Zhao Yanling , Wu Miaohuan , Luo Xinggang
Published: August 2023

Background
In the context of a rapidly aging population, smart healthcare for the elderly has become the focus of social attention in China. Wrist-worn wearable devices (WWD) are a class of smart healthcare products that aim to support smart healthcare for the elderly.
Objective
This paper aims to investigate the factors that influence the acceptance of WWD by the elderly in China.
Methods
A questionnaire survey was launched in Yangtze River Delta. Structural equation modeling is used to study the relationships among the factors in the research model, then test the mediating effect.
Results
A total of 310 valid data samples were collected. Results reveal that 8 of the 11 hypotheses were supported. Mediation analysis results are consistent with the hypothesis testing. Specifically, the indirect effects of subjective norm(SN) and facilitating conditions(FC) on behavioral intention(BI) by perceived risk(PR) are significantly negative; Health consciousness(HC) has a significant, positive, and indirect effect on BI with perceived usefulness(PU) as a mediator; and FC has a significant, positive, and indirect effect on BI with the remote mediator of “perceived ease of use(PEOU) →PU”.
Conclusions
The results indicated that SN, FC and HC influence the elderly’s use intention through mediating variables, including PU, PEOU, and PR. However, HC has no significant, direct impact on BI. This study also highlighted the significance of SN, FC, and PU. This study’s findings not only enrich relevant research, but also provide theoretical support and valuable information for designers, governments, and manufacturers to facilitate better service for elderly healthcare.
Rapid Cyprinid herpesvirus 3 detection using loop-mediated isothermal amplification (LAMP) combined with gold nanoprobes and SYBR safe
Authors: Bavarsad Meysam , Abed-Elmdoost Amirreza , Tabandeh Mohammad Reza , Farahmand Hamid , Alishahi Mojtaba , Mirvaghefi Alireza
Published: August 2023

As an etiological agent of a notifiable and emerging disease, Cyprinid herpesvirus 3 (CyHV-3 or koi herpesvirus, KHV) is a highly risky factor that affects koi and common carp yield through increasing the mortality rates. In the current study, a highly rapid and sensitive technique was established to detect CyHV-3 with the help of one step loop-mediated isothermal amplification (LAMP) method with dual visualizing indicators (SYBR safe and gold nanoparticle probes; AuNP-probes). Six specific primers were used to amplify the thymidine kinase (TK) of CyHV-3 using a LAMP reaction of 45 min at 65°C along with detecting the products through visual inspection via hybridization at 65°C for 5 min with a functionalized thiol-AuNP probe. A closed-tube LAMP-SYBR safe assay was also developed under the same condition without AuNP probe. The amplification of KHV-LAMP products were evaluated by the naked eye, through fluorescent emission of LAMP-SYBR safe dye-complex and colorimetric aggregate of LAMP product in the presence of AuNP probe. Furthermore, quantitative measurement was applied to the LAMP-AuNPs assay, using the spectral shift assay. The detection limit was 1.25 fg DNA which can compete the latest techniques available. The proposed technique yielded negative outcomes with DNA template from other viruses such as CyHV-1 and CEV. The LAMP-SYBR safe and LAMP-AuNPs assays introduced in this article was very sensitive, fast, and reliable diagnostic tools for CyHV-3 detection.
Simultaneous study of different combinations of ZSM- 5 templates and operating conditions in the MTP process; Designing, Modeling and Optimization by RSM-ANN-GA
Authors: Kalantari Neda , Farzi Ali , Hamooni Faez , Delibaş Nagihan Çaylak , Tarjomannejad Ali , Niaei Aligholi , Salari Dariush
Published: August 2023

Process of converting methanol to propylene is influenced by many parameters. The use of smart techniques can be an effective way to investigate variable parameters and finding optimal conditions. In this work, optimal design of ZSM-5 catalysts with different combinations of templates and operating conditions in methanol to propylene process was performed using response surface methodology and hybrid artificial neural network-genetic algorithm method. Objective functions for optimization were methanol conversion and propylene selectivity. Effects of different variables in the dual-responses system, including molar ratios of tetra propyl ammonium bromide (TPABr), Cetyltrimethylammonium bromide (CTAB), and Pluronic F127, as well as weight hourly space velocity of feed and process temperature on the performance of catalysts, were studied both experimentally and theoretically. Modeling results showed that the designed neural network structure for the process had superior accuracy compared to RSM with correlation coefficients of 0.9976, 0.9950 and 0.9946 for training, validation and testing, respectively. By combining optimal templates, optimum operating temperature of 420 °C and WHSV of 1 h-1 were obtained based on the genetic algorithm to achieve maximum selectivity of propylene and the highest possible conversion of methanol. The optimal catalyst had stable performance under the optimal conditions.
A Blockchain based Provably Secure AnonymousAuthentication for Edge Computing-enabled
Authors: Zhang Shiqiang , Cao Dongzhi
Published: August 2023

Edge computing server deployed at the edge of the network has promoted thedevelopment of the Internet of Things (IoT) but also brings some security prob-lems. Traditional IoT security solutions have not met the requirements of thecurrent rapid growth of equipment, real-time and lightweight. Therefore, thedevelopment of new authentication and key negotiation is becoming an importantmeans to solve the security problems of the IoT. To address this challenge, anauthentication framework for edge computing enabled-Internet of Things environ-ment is proposed to realize the establishment of secure communication betweendevices and edge servers, devices, and devices. Meanwhile, the formal and infor-mal security analysis shows that the proposed protocol meets a wide range ofsecurity attributes and resists many security threats. In addition, the computa-tion consumption and transmission consumption of the protocol are analyzed andcompared. The results show that the proposed protocol has good performance inboth calculation and transmission.
Evaluating the Performance of different large language models on health consultation and patient education in urolithiasis
Authors: Song Haifeng , Xia Yi , Luo Zhichao , Liu Hui , Song Yan , Zeng Xue , Li Tianjie , Zhong Guangxin , Li Jianxing , Chen Ming , Zhang Guangyuan , Xiao Bo
Published: August 2023

Objectives To evaluate the effectiveness of four large language models (LLMs) (Claude, Bard, ChatGPT4, and New Bing) that have large user bases and significant social attention, in the context of medical consultation and patient education in urolithiasis. Materials and methods In this study, we developed a questionnaire consisting of twenty-one questions and two clinical scenarios related to urolithiasis. Subsequently, clinical consultations were simulated for each of the four models to assess their responses to the questions. Urolithiasis experts then evaluated the model responses in terms of accuracy, comprehensiveness, legibility, human care, and clinical case analysis ability based on a predesigned 5-point Likert scales. Visualization and statistical analyses were then employed to compare the four models and evaluate their performance. Results All models yielded relatively qualified results, except for Bard, which failed to provide a valid response to Question 13. Claude consistently scored the highest in all dimensions compared with the other three models. ChatGPT4 ranked second in accuracy, with a relatively stable output across multiple tests, but shortcomings were observed in empathy and care for counsellors. The Bard model exhibited the lowest accuracy and overall performance. Claude and ChatGPT4 both had a high capacity to analyze clinical cases of urolithiasis. Overall, the Claude model emerged as the best performer in urolithiasis consultations and education. Conclusion Claude demonstrated superior performance compared with the other three in urolithiasis consultation and education. This study highlights the remarkable potential of LLMs in medical health consultations and patient education, although professional review, further evaluation, and modifications are still required.
Neighborhood income inequality associated with functional independence after ischemic stroke: a cohort study
Authors: Coté M Kathryn , Pudlo Megan , Jost-Price BA Emma , Leung
Published: August 2023

Background
Individual measures of socioeconomic status have been associated with post-stroke disability in patients with ischemic stroke. However, it is not known whether the distribution of income in a community may have an impact on stroke recovery. We hypothesized that increased neighborhood income inequality (as measured by the Gini index) may be associated with a slower recovery after stroke.
Methods
This was a retrospective cohort study of adult patients hospitalized at a comprehensive stroke center with acute ischemic stroke between 1/1/2018-12/31/2019. Individual patient data was abstracted from the EHR, and zip code Gini index was obtained from the US Census Bureau. Binary logistic regression was used to assess the relationship between Gini index and modified Rankin score at discharge and follow-up. A second binary regression was also performed using a subset of patients to assess possible predictors of being discharged as recommended.
Results
Three hundred and thirty-eight patients were included in this analysis. Zip code Gini index was not associated with functional independence at discharge but was associated with independence at follow-up such that patients from high inequality neighborhoods were less likely to be independent. Each 1% increase in neighborhood Gini index was associated with an 7% decreased likelihood of independence at follow-up. Patients living in the highest income inequality neighborhoods were 220% less likely to achieve functional independence by follow-up compared to those in the lowest inequality neighborhoods. Being discharged as recommended was associated with a higher likelihood of independence at follow-up. Greater income inequality and Asian race were associated with a lower likelihood of being discharged as recommended.
Conclusion
Among a cohort of patients with ischemic stroke, increased neighborhood income inequality was associated with a lower likelihood of achieving functional independence by the time of outpatient follow-up. This disparity may be driven by discharge destination and race.
What is the Relationship Between the Diagonal Method and the Continuum Hypothesis?
Authors: KUNT İBRAHİM
Published: August 2023

Cantor used a hypothetical list to prove that real numbers in the range (0,1) are uncountable. The indexes of the numbers in this list are natural numbers, and I agree that Cantor's proof is true for a list where the indexes are natural numbers. However, Cantor proved that the cardinality of real numbers in the in the range (0,1) is greater than ω in this proof. He also defined the number ω1 as greater than all natural numbers. Therefore, I add a real number to this list that I assume is in the range (0,1) and has an index of ω1. Then, I use a similar method to what Cantor did with his hypothetical list; I mean I try to find a real number that is not in the range (0,1) in my new hypothetical list. However, this new method differs from the Cantor diagonal method because in this new list, it is assumed that there is a real number whose index is not a natural number. I call this new method DM2 and using this method, I study the cardinality of digits of real numbers that exist in a defined range. I present some new results regarding the Continuum Hypothesis via this method.
COVID-19 and Vestibular Disorders: Is Quality of Life really affected? A narrative review
Authors: Valencia Santiago , Franco Isabela , Gonzalez Sara , Castillo-Bustamante Melissa , Madrigal Jorge
Published: August 2023

The coalescence of vestibular disorders and the COVID-19 pandemic has given rise to a burgeoning area of investigation. This review delves into the intricate relationship between vertigo, often associated with COVID-19, and its profound implications on individuals' quality of life. We explore the evolving understanding of how COVID-19 may trigger or exacerbate vertigo in those with existing vestibular conditions. Furthermore, we emphasize the necessity for in-depth research to elucidate the vestibular involvement in COVID-19 and its consequences on quality of life. While the pandemic's acute phase may have waned, the persistence of COVID-19 cases globally emphasizes the urgency of continued research into the intricacies of vertigo in the context of this viral infection. Ultimately, this narrative review serves as a valuable resource for healthcare professionals, researchers, and policymakers seeking to better understand and address the multifaceted challenges posed by vertigo in the era of COVID-19.
Utilizing Bioinformatics Approaches to Conduct Comparative Analysis of the Thyroid Transcriptome in Thyroid Disorders
Authors: Andrade Luis Jesuino de Oliveira , de Oliveira Luís Matos , Bittencourt Alcina Maria Vinhaes , de Oliveira Luisa Correia Matos , de Oliveira Gabriela Correia Matos
Published: August 2023

Introduction: This study aims to identify common gene expression patterns and dysregulated pathways in various thyroid disorders by leveraging publicly available transcriptomic datasets. The integration of other omics data, when possible, will allow us to uncover potential molecular drivers and biomarkers associated with specific thyroid dysfunctions. However, there are still gaps in the analysis of the transcriptomes of the various thyroid disorders.
Objective: To conduct a comparative analysis of the thyroid transcriptome in thyroid disorders using bioinformatics approaches.
Methods: We retrieved publicly available gene expression datasets related to the thyroid from European Nucleotide Archive. Data preprocessing involved conducting quality control, trimming reads, and aligning them to a reference genome. Differential expression analysis was performed using bioinformatics packages, and functional enrichment analysis was conducted to gain insights into biological processes. Network analysis was conducted to explore interactions and regulatory relationships among differentially expressed genes (DEGs).
Results: Our analysis included a total of 18 gene expression datasets, of which 15 were selected based on inclusion criteria and quality assessment. A large number of DEGs were identified (p < 0.01), and these genes were ranked according to their significance. Functional enrichment analysis revealed numerous biological processes associated with the DEGs, providing insights into the molecular mechanisms of thyroid disorders. Network analysis using Cytoscape software revealed potential interactions among DEGs and identified key hub genes and potential therapeutic targets.
Conclusion: This study demonstrates an accessible methodology for conducting a comparative analysis of the thyroid transcriptome in different disorders without the need for thyroid tissue samples. The integration of bioinformatics approaches provides a comprehensive understanding of the molecular mechanisms underlying thyroid diseases.
Feel properties, thermal stability and colour combination compatibility of nano-LDH on cotton
Authors: Khandual Asimananda , Barik Sunita , Luximon Yan , Dash Bhibhu Prasad , Pradhan Swikruti , Luximon Ameersingh
Published: August 2023

In our prior study, we investigated how reactive dyeing of cotton with Mg-Al Layered Double Hydroxide (LDH) nanoparticles improved the fabric's mechanical, UV protection, and flame retardancy capabilities. Low concentration ranges allow for a safer application for wearables, according to characterization and cytotoxic data. To establish industrial applications, it is necessary to look at their objective testing on feel and comfort qualities, thermal stability, and color combination compatibility. In the current inquiry, we experimented with a fabric touch tester (FTT) for the objective evaluation of feel, and then we used a simultaneous thermal analyzer (STA) to examine the thermal stability of treated cotton. In order to ensure commercial use, three sets of Ultra RGB dyes and their mixing were also used, and their dye absorbing capabilities to provide a broad color spectrum were explored. From CIE chromaticity study, it was discovered that they can be used in place of common dyes with a reliable color forecast for dye combinations. The FTT results show that with the addition of LDH nanoparticles to cotton, the fabric's smoothness, softness, and overall PSI steadily decline, but that smoothness is the only significant aspect of overall feel or PSI. LDH was included into the fiber matrix, which boosted thermal stability.
The Impact of Rural Saving and Credit Cooperative on Household Saving: The Case of Ginir District, Oromia, Ethiopia
Authors: Girma Berhanu , Alemayehu Muluken
Published: August 2023

This study was carried out to determine the impact of rural credit and saving cooperatives on household saving. Data was collected from primary source using questionnaire method. To select sample respondents multi-stage sampling technique were followed. First Ginir district was purposefully selected. Then after, a simple random sampling technique was employed to select three kebales from the district. Finally, using systematic random sampling technique 295 sample household were selected. Logit, and Propensity Score matching methods were employed for data analysis. The results of the logit regression model identified that family size and distances from RUSACCO office, sex of the household head, marital status of household head, education level, access to training, access to credit and amount of loan borrowed affect households’ membership in RUSACCOs. Propensity score matching (PSM) method was also employed to determine the impacts of membership in RUSACCO on household saving in the study area. The estimation result presented that, on average, membership of households in RUSACCO have increased amount of saving by 2627.9 birr during the survey year. The estimated average treatment effect (ATT) showed that membership of households in RUSACCO has significant impact on saving of member households with significant t-statistic (6.18) at 1 percent significance level. The average amount of saving of members households was higher by 37.4 percent when compared with the average amount of saving of non-member households in the study area during survey year.
Associations between peripheral cytokines, perceived fatigue and event-related potentials during a sustained attention task in depressive episodes: a case-control study
Authors: Pedraz-Petrozzi Bruno , Lamade Eva Kathrin , Hübner Nils , Seifert Jil , Neumann Elena , Sammer Gebhard
Published: August 2023

This case-control study investigated the associations between peripheral inflammation, perceived fatigue, and event-related potentials (ERP) during a sustained attention test (SAT) in depression. Participants included 25 individuals with depressive episodes (DE) and 31 healthy controls (HC). A 15-minute SAT (subtest of the Test Battery for Attention, version 2.3.1) was administered with concurrent EEG recordings. Peripheral inflammation was assessed by measuring IL-6, IL-1β, and TNF-α cytokines. Linear mixed models and generalized linear models were utilized for data analysis. Our results showed that the DE group exhibited lower P300 amplitudes than HC (estimate = -0.98, CI95 [-1.60; -0.35], p = 0.004). Furthermore, P300 amplitudes were inversely associated with IL-6 (estimate = -1.73, CI95 [-3.27; -0.19], p = 0.03), regardless of group status. Surprisingly, higher perceived fatigue correlated with increased P300 amplitudes, irrespective of group status (estimate = 0.009, CI95 [0.0004; 0.02], p = 0.05). Finally, accuracy, measured as the total number of correct answers in the SAT, correlated negatively with TNF-α (OR = 0.44, CI95 [0.27; 0.70]). However, no significant effects were found for P300 latency or reaction time in the SAT when comparing DE and HC. The study highlights the potential role of peripheral inflammation on sustained attention in cognitive performance. Due to the low interaction effect, fatigue and P300 amplitude results must be interpreted cautiously. Although P300 amplitudes were lower in DE, no significant association was observed between DE and inflammation in ERP and cognitive performance. Further research is required to confirm these findings.
Analysis of 14 β-agonists in pork using automated wooden tip based SPME device and UPLC-MS/MS
Authors: Li Kai , Gong Xiaoming , Jin Liming , Liu Mengxiao , Hua Mengmeng
Published: August 2023

This study presents an innovative analytical method for the detection and quantification of 14 β-agonists in pork using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The method involves the use of a solid phase microextraction (SPME) probe, consisting of a wooden tip coated with polyacrylonitrile (PAN) and molecularly imprinted polymer (MIP). This probe has been integrated into an automated extraction device, designed in our laboratory to extract the target analytes prior to LC-MS/MS analysis. Compared to the traditional solid-phase extraction (SPE) procedure, the proposed approach significantly reduces the costs related to adsorbent material and solvent consumption, and shortens purification time, thereby reducing both the technical workload and associated expenses. The methodology has been carefully validated in accordance with the National Standard of the People's Republic of China (GB/T 22286-2008), evaluating key parameters including the limit of detection (LOD), limit of quantification (LOQ), matrix effects, linearity, and both intra-day and inter-day precision. The average recovery rates for all β-agonists were observed to lie between 71.6% and 82.2%, with relative standard deviations (RSDs) consistently below 15% for both types of precision. The LOD and LOQ values were found to range from 0.09 to 0.39 μg/kg and 0.27 to 0.99 μg/kg, respectively. In terms of accurate detection of positive samples, the developed method demonstrated a closer approximation to the true value of the sample compared to the National Standard method GB/T 31658.22-2022. Overall, the proposed method exhibits substantial promise for the routine assessment of β-agonists in pork and presents a practical alternative for compliance monitoring in regulatory settings.
Spatiotemporal variations in seismic activity in and around the focal region of the 2021 M7.3 and 2022 M7.4 Fukushima-Oki earthquakes, Japan
Authors: Chiba Keita
Published: August 2023

The spatiotemporal evolution of seismic activity is presented for a broad region surrounding the focal areas of the 2021 M 7.3 and 2022 M 7.4 Fukushima-Oki earthquakes, which occurred within the subducting slab off the Pacific coast of Fukushima Prefecture, northeastern Japan. This study investigates the spatiotemporal variations in seismic activity during the periods before the 2021 M 7.3 earthquake, between the 2021 M 7.3 and 2022 M 7.4 earthquakes, and after the 2022 M 7.4 earthquake using the b -value of the Gutenberg–Richter relation, the aftershock decay rate ( p -value), and changes in the seismicity rate (Z -value). The study area is also divided into two depth sections to investigate the depth variations in these seismicity parameters relative to the plate interface. The b -values in the deeper section (intraslab) are generally lower than those in the shallower section (around the plate interface) throughout the entire analysis period, including the hypocentral areas of the M 7.3 and M 7.4 earthquakes. The aftershock decay rates for the M 7.3 and M 7.4 earthquakes also show depth-dependent characteristics, with a slower decay rate ( p < 1.0) at many grid nodes in the deeper section than in the shallower section. Furthermore, seismic quiescence was noted in the hypocentral area of the M 7.3 earthquake about two years before the occurrence of this mainshock. The locations of the M 7.3 and M 7.4 earthquakes around the down-dip edge of the slip area of the 2011 M 9.0 Tohoku earthquake suggests that the variations in seismic activity detected in this study mainly reflect stress increases due to the coseismic slip and postseismic deformation of this great earthquake. The present study suggests that the effect of viscoelastic relaxation is a dominant factor in the deeper section. Furthermore, the variations in seismicity may also reflect heterogeneous structures within the slab.
Reproduction Rate and Viability of Nilagiri and Nilagiri Synthetic Breeds of Sheep
Authors: Chaudhari Arth Bhaljibhai , Ramanujam Rajendran , Ragothaman Venkataramanan , Sundaram S. Meenakshi
Published: August 2023

Reproduction data of 4648 Nilagiri and 6542 Nilagiri Synthetic ewe records spreads over 27 years (from 1989 to 2015) representing 4530 Nilagiri and 5950 Nilagiri Synthetic breeding ewes were used in this study. Flocks belonged to the Sheep Breeding Research Station, Sandynallah, India. Flock dynamics of six age groups (1.5–7.5 yrs) were assessed. Ultimate objective of this research work was to evaluate the replacement rate, reproduction rate, flock structure and dynamics of Nilagiri and Nilagiri Synthetic sheep breeds. Three parameters were used to evaluate flock dynamics, age specific replacement rate, net reproduction rate and intrinsic rate of increase or innate capacity for increase of population. The replacement rate estimated was significantly higher (P value < 0.002) in Nilagiri (0.289) than Nilagiri Synthetic sheep (0.260). The age-specific death rates ranged from 0.026 (3.5–4.5 years) to 0.191 (6.5–7.5 years) with highest 0.191 and 0.134 in Nilagiri and Nilagiri Synthetic sheep from 1.5 to 7.5 years of age, respectively. The replacement requirements will be met if the ewes are kept in the flock until five years of age with a net reproduction rate of 1.024 in Nilagiri and if the ewes are kept in the flock until six years of age with a net reproduction rate of 1.196 in Nilagiri Synthetic. Nilagiri ewes in intermediate ages had more multiple births and older ewes weaned more lambs. The flock strength was not maintained unless the ewes were kept till the fifth lambing Nilagiri, third lambing in Nilagiri Synthetic sheep. All estimates tended to increase with dams age up to six years and decreased thereafter. The results of Ro and rm showed that the studied flock must consist of 6 age groups to maintain its size and replace itself. It may be recommended to cull the breeding ewe at the age of 6 years to accelerate genetic improvement. Based on the findings it is concluded that suitable breeding policy of selection and culling of such flock should be formulated.
SOL EL KULLANICISI DİŞ HEKİMLİĞİ ÖĞRENCİLERİNDE DÖNÜŞTÜRÜLEBİLİR DENTAL ÜNİTLERDE EĞİTİM KALİTESİNİN DEĞERLENDİRİLMESİ
Authors: GEDUK Gediz , KOCAK Murat , BODRUMLU Emre , SAĞLAM Baran Can
Published: August 2023

ÖZ

Amaç

Lateralite, insanlarda her bir serebral yarımkürede ve kontrol ettiği vücut bölgesinde özelleşmiş bir işleyişin gelişimini içeren belirli bir farklılığı ifade eder. Lateralitenin en sık karşılaşılan ve dikkat çeken tipi ise el tercihidir. Bu çalışmanın amacı, bir diş hekimliği fakültesindeki sol el kullanıcısı diş hekimliği lisans öğrencilerinin dönüştürülebilir diş ünitlerinde klinik eğitim ve hizmet kalitesini değerlendirmektir.

Gereç ve yöntemler

Bu araştırma Diş Hekimliği Fakültesinde öğrenim gören dönem 4 ve dönem 5 öğrenciler içerisinde sol el kullanıcısı olan 22 öğrencinin gönüllü olarak katılımıyla gerçekleştirilmiştir. Yapılan anket öncesinde öğrencilere anket hakkında bilgi verilmiş olup gönüllülük esası aranmıştır.

Bulgular

Hazırlanan ankete toplamda 22 öğrenci gönüllülük esaslarına göre cevap vermiştir. Bunun üzerine cevap verilen her soru tek tek incelenip sol el kullanıcı hekimlik ve dönüştürülebilir ünitler ile ilgili neticelere varılmaya çalışılmıştır.

Sonuç

Sonuç olarak, sol el kullanıcısı diş hekimliği öğrencilerinde dönüştürülebilir dental ünitler eğitim kalitesini olumlu yönde etkilemektedir.
Effect of different single file systems on the dentin thickness in the danger zone of mandibular first molars
Authors: AKTEMUR TÜRKER Sevinç , GEDUK Gediz , GÖZCÜ Cem
Published: August 2023

Background: To compare the dentin thickness in the danger zone of mandibular molars after preparation with one rotating (XP-endo Shaper) and two reciprocating (One Reci and Reciproc Blue) single file systems using a cone beam computed tomography (CBCT).

Materials and Methods: Thirty-six mesial roots of mandibular first molars having two independent canals were selected. After initial CBCT scans were provided, teeth were assigned into 3 groups related to the single file used: XP-Endo Shaper (XPS), One Reci (OR) and Reciproc Blue (RB). The roots were scanned again after preparation with respective single file systems. The minimum dentine thickness in the danger zone, at 4, 5, 6 and 7 mm below the furcation level, were measured in CBCT scans. Initial and final measurements were used to calculate the removed dentin thickness in the danger zone. Data was analyzed using Repeated-measures ANOVA (p=0.05).

Results : No significant differences were found related with remaining and removed dentin thickness among single file systems at any level from the furcation (p>0.05).

Conclusions: The evaluated single file systems showed similar cutting efficiency in the danger zone of mandibular molars.
Voices of Leadership
Authors: Korenman Lisa , Wetzler Elizabeth , Leahy Samantha , Young Lissa V
Published: August 2023

Previous research shows that voice pitch plays a significant role in leadership selection (Mayew et al., 2013) and that moremasculine traits, including voice pitch, are typically associated with successful individuals in leadership roles. The present studyextended prior research by examining how sex and gender characteristics of voices influence the perception of leadershipqualities within a military environment. Specifically, the design of the study was a 2 (sex of voice: male, female) × 2 (gender ofvoice: masculinized, feminized) × 2 (sex of participant; man, woman) mixed model design, with the sex and gender of voiceserving as the within subjects factors, sex of participant as a between subjects factor, and ratings of military leadership potentialserving as the dependent variable. Results from an analysis of variance showed that participants rated men’s voices significantlyhigher than women’s voices for leadership potential. However, feminine voices were rated significantly higher than masculinevoices. Additionally, there was a significant interaction between sex of voice and gender of voice that showed that the masculinefemale voice received the lowest ratings of leadership potential. Male participants also provided lower ratings on average to allvoices when compared to female participants. We discuss these findings in terms of gender role congruity and the influence ofandrogyny and gender norms on perceptions of women’s leadership potential in a male-dominated, hierarchical environment.