bluuebunny/crossref_metadata_2025 huggingface dataset:
Pathophysiology of Necrotizing Enterocolitis: An Update
Authors: Bazacliu Catalina , Neu Josef
Published: November 2018

NEC is a devastating disease that, once present, is very difficult to treat. In the absence of an etiologic treatment, preventive measures are required. Advances in decoding the pathophysiology of NEC are being made but a more comprehensive understanding is needed for the targeting of preventative strategies. A better definition of the disease as well as diagnostic criteria are needed to be able to specifically label a disease as NEC. Multiple environmental factors combined with host susceptibility appear to contribute to enhanced risks for developing this disease. Several different proximal pathways are involved, all leading to a common undesired outcome: Intestinal necrosis. The most common form of this disease appears to involve inflammatory pathways that are closely meshed with the intestinal microbiota, where a dysbiosis may result in dysregulated inflammation. The organisms present in the intestinal tract prior to the onset of NEC along with their diversity and functional capabilities are just beginning to be understood. Fulfillment of postulates that support causality for particular microorganisms is needed if bacteriotherapies are to be intelligently applied for the prevention of NEC. Identification of molecular effector pathways that propagate inflammation, understanding of, even incipient role of genetic predisposition and of miRNAs may help solve the puzzle of this disease and may bring the researchers closer to finding a treatment. Despite recent progress, multiple limitations of the current animal models, difficulties related to studies in humans, along with the lack of a “clear” definition will continue to make it a very challenging disease to decipher.
Selective Photodynamic Effects on Breast Cancer Cells Provided by p123 Pluronic®- Based Nanoparticles Modulating Hypericin Delivery
Authors: Damke Gabrielle Marconi Zago Ferreira , Souza Raquel Pantarotto , Montanha Maiara Camotti , Damke Edilson , Gonçalves Renato Sonchini , César Gabriel Batista , Kimura Elza , Caetano Wilker , Hioka Noboru , Consolaro Marcia Edilaine Lopes
Published: November 2018

Background:

Breast cancer is the most relevant type of cancer and the second cause of cancer- related deaths among women in general. Currently, there is no effective treatment for breast cancer although advances in its initial diagnosis and treatment are available. Therefore, the value of novel anti-tumor therapeutic modalities remains an immediate unmet need in clinical practice. Following our previous work regarding the properties of the Pluronics with different photosensitizers (PS) for photodynamic therapy (PDT), in this study we aimed to evaluate the efficacy of supersaturated hypericin (HYP) encapsulated on Pluronic® P123 (HYP/P123) against breast cancer cells (MCF-7) and non-tumorigenic breast cells (MCF-10A).

Methods:

Cell internalization and subcellular distribution of HYP/P123 was confirmed by fluorescence microscopy. The phototoxicity and citototoxicity of HYP/P123 was assessed by trypan blue exclusion assay in the presence and absence of light. Long-term cytotoxicity was performed by clonogenic assay. Cell migration was determined by the wound-healing assay. Apoptosis and necrosis assays were performed by annexin VFITC/ propidium Iodide (PI) by fluorescence microscopy.

Results:

Our results showed that HYP/P123 micelles had high stability and high rates of binding to cells, which resulted in the selective internalization in MCF-7, indicating their potential to permeate the membrane of these cells. Moreover, HYP/P123 micelles accumulated in mitochondria and endoplasmic reticulum organelles, resulting in the photodynamic cell death by necrosis. Additionally, HYP/P123 micelles showed effective and selective time- and dose dependent phototoxic effects on MCF-7 cells but little damage to MCF-10A cells. HYP/P123 micelles inhibited the generation of cellular colonies, indicating a possible capability to prevent the recurrence of breast cancer. We also demonstrated that HYP/P123 micelles inhibit the migration of tumor cells, possibly by decreasing their ability to form metastases.

Conclusion:

Taken together, the results presented here indicate a potentially useful role of HYP/P123 micelles as a platform for HYP delivery to more specifically and effectively treat human breast cancers through photodynamic therapy, suggesting they are worthy for in vivo preclinical evaluations.
Symptoms of Toxicity and Plasma Cytochrome c Levels in Human Immunodeficiency Virus-infected Patients Receiving Anti-retroviral Therapy in Ghana: A Cross-sectional Study
Authors: Mensah Eric A. , Sarfo Bismark , Bonney Evelyn Y. , Parbie Prince K. , Ocloo Augustine
Published: November 2018

Background:

Side effects and toxicity have posed a threat to the positive contribution
of Antiretroviral Therapy (ART) in the management of human immunodeficiency virus (HIV) infection
and Acquired Immune Deficiency Syndrome (AIDS). Symptoms of mitochondrial toxicity
including myopathy, pancreatitis, hyperlipidaemia and lactic acidosis are found among HIVinfected
patients on ART. To date, there is not a reliable biomarker for monitoring ART-related
mitochondrial toxicity. Plasma level of Cytochrome c (Cyt-c) has been proposed as a potential
biomarker for ART-related toxicity due to its strong association with apoptosis.

Objective:

The present study assessed toxicity and level of plasma Cyt-c among HIV-infected patients
receiving ART in Ghana.

Methods:

A total of eighty (80) HIV patients were recruited into the study. Demographic data
were obtained from personal interview and medical records. Plasma samples were screened for
toxicity from sixty (60) participants due to limited resources, and plasma Cyt-c levels were determined
using ELISA. Data were analyzed using Stata version 13.

Results:

Out of the 60 participants, 11 (18.3%) were found with symptoms of myopathy, 12
(20%) with pancreatitis, 21 (35%) with hyperlipidaemia and 36 (60%) with at least one of the
symptoms. The concentration of plasma Cyt-c was higher (0.122 ng/ml) in patients with toxicity
than in those without toxicity (0.05 ng/ml), though the difference was not statistically significant
(p = 0.148). There was a weak correlation between plasma Cyt-c level and duration of ART
(Spearman rho = 0.02, p = 0.89).

Conclusion:

This study, therefore, demonstrated a high prevalence of ART-related toxicity and
high levels of Cyt-c in HIV-infected patients in support of the argument that plasma Cyt-c levels
are potential biomarkers for determining ART-related toxicity in HIV patients.
Rancang Bangun Sistem Pendeteksi ARTag sebagai Landasan Pacu AR.Drone Menggunakan Platform ROS (Robot Operating System)
Authors: Sumbodo Bakhtiar Alldino Ardi , Rahardian Ariestyo
Published: November 2018

The development of quadrotor type AR. Drone for research are being developed. One of which is an object detection system based image processing to perform the mission, such as tracking, landing, or detect and pass the object hitch. Accordingly, in this research designed an ARTag detection system based on digital image processing using OpenCV library implemented in ROS platform used to connect the drone to PC which will then be carried out missions to landing. The method used is Thresholding, Contour Detection, and Image Moments.The result of this research is a system that able to detect ARTag objects along with his ID. The system is tested by computing time of the program in the static and dynamic state, detection performance testing in static and dynamic state, detection performance testing of the angle between the ARDrone and ARTag, detection performance testing of the light intensity, and testing landing mission. The conclusions are the optimal height of detection in the static and dynamic state is 150 cm, has excellent reliability to the light intensity, and the ARDrone can perform landing mission with a success rate of 70%.
Perancangan Alat Ukur Massa Jenis Zat Cair Menggunakan Cepat Rambat Gelombang Ultrasonik
Authors: Prawira Nanda Bagus , Rouf Abdul
Published: November 2018

Density is a measure of the mass of volume unity. How to measure density in general by measuring the weight and dividing it by the volume of liquid, so in this way the measurement is not. Measurement of the density of the liquid based on the ultrasonic velocity becomes an alternative so that the measurement can be done directly, accurately, practically, and easily.Ultrasonic velocity becomes the variable to determine the density of the liquid. Time synchronization begins when the ultrasonic transmitter emits ultrasonic and is terminated when the receiver receives ultrasonic. The discrete ultrasonic wave transmission method is performed when the ultrasonic receiver receives transmittance from the ultrasonic transmitter then the 40KHz signal pulse is stopped and ultrasonic transmission is repeated up to 10 times the measurement data.From this study obtained some conclusions. Ultrasonic velocity is influenced by the viscosity of the liquid, ultrasonic velocity through 1394m / s aquades, ultrasonic  velocity through cooking oil 1387m / s, ultrasonic velocity through liquid soap 1175m / s, ultrasonic velocity through liquid soap solution 40% 1317m / s , Ultrasonic velocity through liquid soap solution 70% 1257m / s, velocity measurement deviation of 0.43% and 0.01% density calculation type.
Development of A Pressure Sensing Module and Flow Control System For A Prototype Pump Test Bed
Authors: Nahian Md. Rafsan , Zaman Mohammad Sakalin , Islam Md. Nurul , Rokunuzzaman Md.
Published: November 2018

Pump test bed is essential to ensure the proper functioning of a pump. However, a conventional pump test bed has some limitations during measuring the flow properties and variating the pump speed. As a result, a digital pump test bed can be a solution for measuring the flow properties more accurately. This article describes the construction process of a pressure sensing module for a digitalized pump test bed and control of flow by varying the speed of a prototype DC pump. A pressure sensing module and flow control system are constructed in this study to develop a prototype pump test bed as well as change the speed of the centrifugal pump. It is found that by using a piezoelectric pressure sensor in delivery pipe, the pressure sensing error is only 6.3% at the designed speed of pump and can be minimized by calibrating the sensor, fixing the leakage problem and increasing the pressure of flow. A wide variety of pump speeds can also be obtained by applying pulse width modulation principle without stopping the power supply.
Hybrid Support Vector Machine to Preterm Birth Prediction
Authors: Santoso Noviyanti , Wulandari Sri Pingit
Published: November 2018

Preterm birth is one of the major contributors to perinatal and neonatal mortality. This issue became important in health research area especially human reproduction both in developed and developing country. In 2015 Indonesia rank fifth as the country with the highest number of premature babies in the world. The ability to reduce the number of preterm birth is to reduce risk factors associated with it. This research will be made the prediction model of preterm birth using hybrid multivariate adaptive regression splines (MARS) and Support Vector Machine (SVM). MARS used to select the attributes which suspected to affect premature babies. The result of this research is prediction model based on hybrid MARS-SVM obtains better performance than the other models
The validity of parental-reported body height and weight: a comparison with objective measurements of 7-8-year-old Czech children
Authors: Vendula Zborilova , Miroslava Pridalova , Dagmar Sigmundova , Tereza Kaplanova
Published: November 2018

The values of body weight and height can be recorded in various ways. Self-reports and parentalreport methods are amongst the most typical ways to collect data. These methods have advantages, but also limits. Anthropometric measures are recommended to improve measurement precision. The aim of this study was to investigate whether the parental-reported body weight and height of 7-8-year-old Czech children corresponded with the measured body weight and height. Data concerning children’s body weight and body height were collected via parental informed consent and anthropometric measurements. The research sample consisted of 388 children from 7 to 8 years-old (boys, n = 176; girls, n = 162). Only children with parental informed consent were included. Correlations between parental-reported and measured data were analysed with the Pearson correlation coefficient to examine the strength of linear dependence between the two methods. The differences between parental-reported and measured data were tested using the Wilcoxon signed-rank test. P-values below α = 0.05 were considered statistically significant. Parents manifested a tendency to underestimate body weight and especially the body height of their children. This trend was seen in boys and girls in both age groups. Out of the 338 children with parent-reported height, parents under-reported their child’s height by 1 cm or more in 37.1% of the children, 39.6% of the parents reported a height within 0.99 cm of the measured height, and 23.3% of parents over-reported their child’s height by 1 cm or more. The same number of children had parentreported weights, parents under-reported their child’s weight by 1 kg and more in 25.2% of the children, 57.7% of the parents reported a weight within 0.99 kg of the measured weight, and 17.1% of the parents over-reported their child’s weight by 1 kg or more. The Pearson correlation coefficient between the measured and parental-reported height and weight revealed a statistically significant strong positive linear relationship in both genders (rheight = 0.912, rweight = 0.943; all p< 0.001). The differences between the measured and parental-reported height and weight were not significantly different (all p< 0.05). The high agreement and correlation between measured and parental-reported body height and weight suggest that parental-report methods can be an appropriate alternative to objective measurement and can be used as a valid tool to classify body height and weight for large population studies of Czech children in school-based research when anthropometric measures are not available.
Luis MORENO y Raúl JIMÉNEZ, Democracias Robotizadas. Escenarios Futuros en Estados Unidos y la Unión Europea, Madrid, Catarata, 2018. 158 páginas
Authors: Ramió Matas Carles
Published: November 2018

Luis Moreno y Raúl Jiménez, Democracias Robotizadas. Escenarios Futuros en Estados Unidos y la Unión Europea.
Rancang Bangun Sistem Informasi Pemberitaan di RRI Madiun Berbasis Desktop
Authors: Malik Imam Abdul
Published: November 2018

Perkembangan teknologi informasi yang sangat pesat di era globalisasi saat ini telah memberikan banyak manfaat dalam kemajuan diberbagai bidang. Saat ini laporan-laporan administrasi pemberitaan RRI Madiun masih dikerjakan oleh tujuh pegawai. Selain itu, pengecekan laporan harus dilakukan satu per satu dikarenakan laporan tidak terhubung satu sama lain. Hal tersebut disebabkan karena pengerjakan laporan masih menggunakan aplikasi Microsoft Word. Laporan yang tidak saling terhubung menyebabkan terjadi ketidaksesuaian antar laporan. Tujuan penelitian ini adalah merancang dan membangun sistem informasi pemberitaan di RRI Madiun yang dapat menghasilkan laporan administrasi pemberitaan dengan mudah, cepat dan sinkron.Selain itu dapat mengoptimalkan kinerja pegawai. Model pengembangan sistem yang digunakan dalam penelitian adalah Model Waterfall. Adapun langkah pengembangan metode ini adalah sebagai berikut: analisis, perancangan, pengkodean, pengujian, penerapan dan perbaikan. Hasil dari penelitian menunjukan sistem informasi pemberitaan menghasilkan laporan pengiriman berita, laporan produksi komentar, laporan dialog, laporanpeta liputan, laporan siaranl angsung, dan laporan ROS (Report On The Spot). Kinerja staff admin di seksi pemberitaan RRI Madiun dapat dioptimalkan dengan sistem informasi pemberitaan, sehingga tidak memerlukan banyak tenaga untuk mengerjakan administrasi.
Sistem Pendukung Keputusan Pengajuan dan Penilaian Beasiswa Berbasis Website Menggunakan Metode TOPSIS
Authors: Ibrahim Malik
Published: November 2018

Setiap perguruan tinggi khususnya Universitas memiliki banyak sekali program kerja yang ditawarkan bagi mahasiswa, salah satunya adalah beasiswa. Universitas PGRI Madiun (UNIPMA) juga menyediakan beasiswa bagi mahasiswanya, namun dalam proses pemberian beasiswa masih mengalami kendala dalam proses penghitungan penilaian beasiswa yaitu membutuhkan waktu lama dan masih menggunakan aplikasi sederhana dengan bantuan software microsoft excel. Tentunya, hal ini akan menghambat waktu dalam proses kecepatan pengolahan nilai penerimaan beasiswa.Beasiswa ini memiliki beberapa syarat dan kriteria untuk dinilai maka diperlukan suatu sistem yang mampu memutuskan dengan objektif. Metode penghitungan dan memecahan masalah dalam penelitian ini adalah menggunakan metode fuzzy TOPSIS sedangkan pengembangan sistem menggunakan model pengembangan waterfall. Tahapan pertama adalah analisis kebutuhan, kemudian menentukan desain meliputi perancangan user interface, perancangan sistem basisdata, percancangan sistem flowchart, perancangan ERD dan perancangan DFD. Selanjutnya penulisan kode program, kemudian tahapan terakhir adalah pengujian, implementasi dan pemeliharaan sistem. Sistem ini akan membuat keputusan yang dihasilkan benar benar tepat sasaran sesuai untuk menjalankan proses penilaian dengan banyak kriteria sehingga dapat mempercepat dalam pengolahan penerima beasiswa harapan dengan adanya sistem ini dapat membantu Biro Akademik dan Kemahasiswaan selaku pengolah nilai beasiswa dalam menentukan penerima beasiswa dengan cepat, tepat dan optimal
Sikap dan Tindakan Masyarakat Terhadap Orang Gila dan Kampung Gila Desa Paringan Kecamatan Jenangan Kabupaten Ponorogo
Authors: Widayat Muh. Aziz
Published: November 2018

Penelitian ini bertujuan menganalisis dan mendeskripsikan sikap dan tindakan masyarakat terhadap orang gila dan kampung gila Desa Paringan Kecamatan Jenangan Kabupaten Ponorogoa. Penelitian dilaksanakan selama 6 bulan dengan menggunakan pendekatan kualitatif dan metode field research (penelitian lapangan). Informan ditentukan secara purposive sampling. Pengumpulan datanya dengan teknik observasi, wawancara, dokumentasi. Untuk mendapatkan keabsahan data menggunakan triangulasi sumber. Sedangkan teknik analisis datanya dengan model analisis interaktif  Miles dan Huberman. Dari penelitian yang dilakukan diperoleh hasil bahwa sikap masyarakat Desa Paringan walaupun berat namun menerima warga yang mengalami gangguan jiwa (gila). Mereka berusaha melakukan berbagai tindakan untuk membantunya agar warga yang mengalami gangguan jiwa diperlakukan secara manusiawi. Selain itu, untuk mengelimir stigma negatif desanya, masyarakat beserta aparatur pemerintahan desa melaksanakan kegiatan diantaranya; (1) memberdayakan sumber daya alam sebagai destinasi wisata, (2) memberdayaakan ekonomi masyarakat dengan pengolahan diversifikasi makanan ringan.
PELATIHAN AKUNTANSI DAN PENYUSUNAN LAPORAN KEUANGAN BAGI MANAJER DAN STAF KEUANGAN KOPERASI USAHA PENANAMAN DAN PENGOLAHAN KOPI DI KABUPETEN ACEH TENGAH DAN BENER MERIAH
Authors: BZ Fazli Syam , Iskandarsyah Iskandarsyah , Evayani Evayani , Afrianandra Cut
Published: November 2018

Abstract. The accounting and financial reporting training aims to provide knowledge (methods / techniques) and accounting practices that start from the accounting cycle in preparing financial statements for cooperative managers and finance staff towards transparent, accountable, accountable, self-sustaining and transparent cooperative governance justice. The cooperative must have a reliable and valid financial management system so that cooperative management that is familial and mutual cooperation requires the active participation and participation of all stakeholders.The training was conducted at the Coffe and Coffeemaking Cooperative in Central Aceh and Bener Meriah Regency involving 45 participants from 13 cooperatives consisting of Managers and Finance Staff. The training was conducted for 3 (three) dated March 17 - 19, 2017. In the initial phase, training needs analysis has been done to obtain preliminary information about understanding and accounting practices in the targeted cooperatives.The final outcomes of training for cooperatives are the preparation of the Preliminary Balance Sheet and the Financial Statements of Cooperatives for the period of December 31, 2016 and the continuing recording of transactions for the period of 2017 until the preparation of the Financial Statements of December 31, 2017.

Keywords: Accounting, Financial Statement, Cooperative, Governance

 

 

Abstrak.Pelatihan akuntansi dan penyusunan laporan keuangan ini bertujuan untuk memberikan pengetahuan (metode/teknik) dan praktik akuntansi yang dimulai dari siklus akuntansi dalam menyusun laporan keuangan bagi para manajer dan staf keuangan koperasi guna menuju tata kelola koperasi yang transparan, akuntabel, bertanggungjawab, mandiri, dan berkeadilan. Koperasi harus memiliki sistem manajemen keuangan yang handal dan valid sehingga tata kelola koperasi yang bersifat kekeluargaan dan gotong royong menuntut peran dan partisipasi aktif dari seluruh anggota (stakeholder). Pelatihan ini dilakukan pada Koperasi Usaha Penamanan dan Pengolahan Kopi di Kabupaten Aceh Tengah dan Bener Meriah yang melibatkan 45 orang peserta dari 13 Koperasi yang terdiri dari Manajer dan Staf Keuangan. Pelatihan dilakukan selama 3 (tiga)  tanggal 17 – 19 Maret 2017. Pada tahap awal telah dilakukan analisis kebutuhan pelatihan guna mendapatkan informasi awal tentang pemahaman dan praktik akuntansi pada koperasi yang disasar.Dampak akhir (outcome) dari pelatihan bagi koperasi adalah tersusunnya Neraca Awal dan Laporan Keuangan Koperasi untuk periode 31 Desember 2016 dan berlanjutnya pencatatan transaksi periode tahun 2017 sampai tersusunan Laporan Keuangan 31 Desember 2017.

Kata Kunci: Akuntansi, Laporan Keuangan, Koperasi, Tata Kelola
PELATIHAN KEWIRAUSAHAAN DAN KOPERASI BERBASIS SYARIAH BAGIPELAKU UMKM DI CEMPAKA PUTIH JAKARTA PUSAT
Authors: Muslikh Muslikh , Deviastri Lily , Hidayati Rini
Published: November 2018

Abstract.The purpose ofthisprogramis to raise awarenessandentrepreneurialskillsfor SMEs enterprise.The method usedis byapproachingthe SMEs enterpriseto identifythe problemsfaced bythem. The training methods were given by lectures anddiscussionsaboutentrepreneurship. The resultis the increasing of awarenessand understanding ofentrepreneurshipincluded:finance, banking, accounting, marketing, productionand cooperatives. Therefore,entrepreneurship training for SMEs enterprise should be donecontinuously, thus increasingsales turnover.

Keyword: Training, Entrepreneurship, Cooperation, Based on Syariah, SMEs Enterprise

 

Abstrak. Tujuan program ini adalah untuk meningkatkan kesadaran dan kemampuan kewirausahaan dan perkoperasian bagi pelaku usaha kecil (UMKM). Metode yang dipergunakan adalah mengadakan pendekatan dengan mitra pelaku usaha kecil untuk mengidentifikasi permasalahan-permasalahn  yang dihadapi UMKM. Metode pelatihan dengan ceramah dan diskusi tentang kewirausahan dan perkoperassian berbasis dsyariah. Hasil yang dicapai adalah meningkatnya kesadaran dan pemahaman tentang kewirausahan dan perkoperasian berbasis syariah yang meliputi aspek: keuangan  syariah, perbankan syariah, akuntansi syariah, pemasaran online. Pelatihan kewirausahaan dan koperasi berbasis syariah bagi pelaku usaha kecil perlu dilakukan secara berkesinambungan untuk meningkatkan kinerja UMKM.

Keyword: Pelatihan, Kewirausahaan, Koperasi , Berbasis Syariah, UMKM
PENGUATAN KEMAMPUAN BENDAHARA DAN GURU SD MELALUI PEMBELAJARAN AKUNTANSI DASAR DI SDN MEKARWANGI, DS. MEKARWANGI, KEC. CISAUK, TANGERANG-BANTEN
Authors: Effendi Bahtiar
Published: November 2018

Abstract. This activity aims to provide an adequate learning about the basic accounting of nonprofit entities to strengthen the ability of treasurers and teachers in recording and reporting of school financial books. The target of this activity is the teachers especially the school treasurer of SDN Mekarwangi.
Problems resolved through two stages of learning and mentoring activities. The results of this activity show a positive impact with the improvement of teachers' skills related to school bookkeeping with the provision of the Principal's decision to appoint one teacher of the lesson participants to assistant treasurer. In addition, the results of other activities of the basic accounting concepts have been implemented in the private business of one of the teachers of the learning participants through the business of its sweet potato chips. 

 

Abstrak. Kegiatan ini bertujuan memberikan pembelajaran memadai mengenai akuntansi dasar entitas nirlaba guna penguatan kemampuan bendahara dan guru dalam pencatatan dan pelaporan pembukuan keuangan sekolah. Sasaran kegiatan ini adalah guru-guru terutama bendahara sekolah SDN Mekarwangi. Permasalahan diselesaikan melalui dua tahapan yakni kegiatan pembelajaran dan pendampingan. Hasil kegiatan ini menunjukkan dampak positif dengan peningkatan kemampuan guru terkait pembukuan sekolah dengan dibuktikannya keputusan Kepala Sekolah mengangkat satu guru peserta pembelajaranmenjadi asisten bendahara. Selain itu, hasil kegiatan lainnya konsep akuntansi dasar telah diimplementasi dalam usaha pribadi milik salah satu guru peserta pembelajaran melalui usaha keripik ubinya.

 
Drug Analogs from Fragment Based Long Short-Term Memory Generative Neural Networks
Authors: Awale Mahendra , Sirockin Finton , Stiefl Nikolaus , Reymond Jean-Louis
Published: November 2018

Several recent reports have shown that long short-term memory generative neural networks (LSTM) of the type used for grammar learning efficiently learn to write SMILES of drug-like compounds when trained with SMILES from a database of bioactive compounds such as ChEMBL and can later produce focused sets upon transfer learning with compounds of specific bioactivity profiles. Here we trained an LSTM using molecules taken either from ChEMBL, DrugBank, commercially available fragments, or from FDB-17 (a database of fragments up to 17 atoms) and performed transfer learning to a single known drug to obtain new analogs of this drug. We found that this approach readily generates hundreds of relevant and diverse new drug analogs and works best with training sets of around 40,000 compounds as simple as commercial fragments. These data suggest that fragment-based LSTM offer a promising method for new molecule generation.
Quantum Chemical Topology as a Theory of Open Quantum Systems
Authors: Martín Pendás Angel , Francisco Evelio
Published: November 2018

We show how Quantum Chemical Topology can be interpreted within the Theory of Open Quantum Systems. Chemical bonding can then be understood as a consequence of entanglement. The computational implementation is based on the PROMOLDEN code, which is available upon request from the same authors.
Synthesis of Cationic Gold(Iii) Complexes Using Iodine(Iii)
Authors: Albayer Mohammad , Dutton Jason
Published: November 2018

It is shown that halides are important in inducing scrambling in Au(III) coordination complexes, and that monodentate phosphines are less compatible than carbenes with Au(III)
Analisis Strategi Pemasaran Mengunakan Metode Quantitative Strategic Planning Matrik (QSPM) Studi Kasus : Borneo Project
Authors: Mujahid Anas , Isharyani Murianai Emelda , Widada Dharma
Published: November 2018

Borneo Project is a new business in the field of ordering services of various types of clothing. In doing its marketing strategy Borneo Project relies on marketing through friendship, word of mouth from one to another one and using social media as a marketing tool. This has not had a much positive effect on sales in Borneo Project. Therefore it is necessary to analyze the marketing strategy that can be applied in Borneo Project.

Determining the strategy carried out in three stages: an input stage, matching stage, and the stage of the decision. The input stage is done by using Internal Factor Evaluation Matrix (IFE) and External Factor Evaluation Matrix (EFE). In the IFE matrix, obtained a total score of 2.407, while the EFE Matrix obtained score of 2.831. Based on internal and external factor analysis then matching phase with IE Matrix method and SWOT Matrix. The final stage was the decision stage used QSPM method. QSPM is used to evaluate alternative strategies obtained in the SWOT Matrix, then rank them. The first rank is the strategy of applying for credit funds, seeking investors or business joint venture partners and seeking financial assistance from corporate CSR with the acquisition of power score Pull of 5,824. Alternative strategies are prioritized to be applied is to ask a credit fund, seek a joint venture partner and investor or business and are looking for financial aid CSR.
Keywords: Marketing Strategy, Borneo Project, QSPM
Columbine pollination success not determined by a proteinaceous reward to hummingbird pollinators
Authors: LoPresti Eric
Published: November 2018

Plants provision pollinators with a variety of nutritious or otherwise beneficial rewards. Hummingbirds (primarily Calypte anna) pollinate the columbine Aquilegia eximia. In addition to drinking nectar, they glean entrapped insects from its sticky surfaces. To test the hypothesis that this insect carrion, an abundant and easily-collected protein source, serves as a provision to the pollinator and increases pollination I experimentally manipulated this reward and measured pollination success. I set up three treatments - an insect carrion addition, carrion removal, and an unmanipulated control - on small patches of the plant in each of five populations of A. eximia. Pollination success, measured by seed set in emasculated flowers, was unaffected by carrion level. Pollination success positively correlated with average floral display in each patch; this suggests that local nectar reward in an area is more important than this proteinaceous reward in determining pollination success. Stickiness in this system may function as an effective exclusion mechanism for smaller-bodied pollinators. While this study did not demonstrate that captured insects increased reproductive success of this columbine, this interaction (and pollinator exclusion) may play a role in other hummingbird-plant interactions, as hummingbird pollination and insect-entrapment occur together in at least nine species of six plant families.
Bee diversity and floral resources along a disturbance gradient in Kaya Muhaka Forest and surrounding farmlands of coastal Kenya
Authors: Chiawo David Odhiambo , OGOL Callistus K.P.O. , Kioko Esther N. , Otiende Verrah A. , Gikungu Mary W.
Published: November 2018

Bees provide important pollination services that maintain native plant populations and ecosystem resilience, which is critical to the conservation of the rich and endemic biodiversity of Kaya forests along the Kenyan Coast. This study examined bee composition and floral resources from the forest core to the surrounding farmlands around Kaya Muhaka forest. In total, 755 individual bees, representing 41 species from three families were recorded: Apidae, Halictidae and Megachilidae. Overall, Apidae were the most abundant with a proportion of 76% of the total bee individuals, Halictidae at 14% and Megachilidae at 10%. Bee composition was similar between forest edge and crop fields as compared to forest core and fallow farmlands. We found a significant decrease in bee diversity with increasing distance from the forest to the surrounding farming area. A high abundance of bees was recorded in fallow farmland, which could be explained by the high abundance of floral resources in the habitat. We found floral resources richness to significantly affect bee species richness. These findings are important for understanding the effects of land use change on insect pollinators and their degree of resilience in disturbed habitats.
Stability of alpha-helical and beta-structural blocks in proteins of four structural classes
Authors: Poboinev V. V. , Khrustalev V. V. , Khrustaleva T. A. , Stozharov A. N.
Published: November 2018

In this article we showed the characteristic structural features of the groups of interacting alpha-helices and beta-strands (blocks) in four sets of nonhomologous proteins from different structural classes. Stability of each element of secondary structure has been checked with help of the PentaFOLD algorithm that finds intrinsic alpha-helical and beta-structural sequences of amino acid residues. We proved that the most frequent blocks of “alpha + beta” and “alpha/beta” proteins are 2 interacting alpha helices, and they demonstrate the highest level of stability. In alpha-helical proteins the most frequent blocks contain 4 alpha-helices. In beta-structural proteins alpha-helices most frequently do not interact with other helices and demonstrate the lowest level of stability. The most stable type of beta-structure is a block made from three interacting beta-strands, while the less stable one is a beta-hairpin. There is a characteristic distribution of stable alpha-helices in “alpha + beta” proteins: they are usually situated in the beginning of a block while stable beta-strands are usually situated in the end of the block. This type of distribution of stable alpha-helices and beta-strands helps the protein to form its stable three-dimensional structure in case  it begins from beta-structural domain which is the most frequent case for the structural class of proteins.
Operator interpolation formulas of Hermitе type with arbitrary multiplicity nodes based on identity transformations of function
Authors: Ignatenko M. V.
Published: November 2018

The problem of construction and research of Hermite interpolation formulas with nodes of arbitrary multiplicity for operators given in functional spaces of one and two variables is considered. The construction of operator interpolation polynomials is based both on interpolation polynomials for scalar functions with respect to an arbitrary Chebyshev system and on identity transformations of functions. The reduced operator formulas contain the Stieltjes integrals and the Gateaux differentials of an interpolated operator and are invariant for a special class of operator polynomials of appropriate degree. For some of the obtained operator polynomials, an explicit representation of the interpolation error is found. Particular cases of Hermite formulas based both on the integral transformations of Hankel, Abel, Fourier and on the Fourier sine (cosine) transform are considered. The application of separate interpolation formulas is illustrated by examples. The presented results can be used in theoretical research as the basis for construction of approximate methods for solving integral, differential and other types of nonlinear operator equations.
Functional integrals method for systems of stochastic differential equations
Authors: Ayryan E. A. , Egorov A. D. , Kulyabov D. S. , Malyutin V. B. , Sevastyanov L. A.
Published: November 2018

Systems of stochastic differential equations, for which the Riemannian manifold generated by a diffusion matrix has zero curvature, are considered in this article. The method for approximate evaluation of characteristics of the solution of the systems of stochastic differential equations is proposed. This method is based on the representation of the probability density function through the functional integral. To compute functional integrals we use the expansion of action with respect to a classical trajectory, for which the action takes an extreme value. The classical trajectory is found as the solution of the multidimensional Euler – Lagrange equation.
Molecular dynamics for structural complexes of potential HIV-1 inhibitors with the viral envelope gp120 protein
Authors: Kashyn I. A. , Nikolaev G. I. , Tuzikov M. A. , Andrianov A. M.
Published: November 2018

Molecular dynamics simulations for the structural complexes of potential HIV-1 inhibitors with the viral envelope gp120 protein were carried out. Free energies of the formation of these supramolecular structures and contributions of individual amino-acid residues of gp120 to the enthalpy binding were calculated. The residues of gp120 critical for interactions with the ligands were identified. Based on the data obtained, five compounds promising for synthesis and testing for antiviral activity were selected. It is suggested that these compounds may be successfully used in the design of novel, potent and broad anti-HIV drugs.
Construction of a strain-producer of the chimeric protein consisting of RNA polymerase and a DNA-affinity domain
Authors: Kazlovskiy I. S. , Zinchenko M. A.
Published: November 2018

One of the recent perspective trends of molecular biotechnology is cell-free synthesis of protein. The procedure of cell-free synthesis of protein is based on in vitro reconstruction of all stages of a biosynthesis of protein in a whole cell, including a transcription, an aminoacylation of tRNA and translation of mRNA by ribosomes. Procreation of the transcription stage requires participation of specific RNA polymerase which initiates process of mRNA synthesis from the particular sites of recognition. Often the DNA-dependent RNA polymerase of a bacteriophage of T7 (T7 RNA polymerase) is for this purpose applied. For improvement of qualitative characteristics of the T7 RNA polymerase in the real work the new strain of Escherichia coli producing this enzyme fused with the DNA-affine Sso7d domain of a thermophilic bacterium Sulfolobus solfataricus is created. The producing ability of the received recombinant strain concerning synthesized chimera protein reaches 625 un/l of cultural liquid, and the specific activity of the purified enzyme preparation was 80 un/ μg of protein. The received enzyme is intended for use as tools at synthesis of proteins in cell-free system.
Plasmon-active silver nanostructures in the pores of ion-track template of SiO2 on silicon
Authors: Yakimchuk D. V. , Kaniukov E. Yu. , Bundyukova V. D. , Demyanov S. E.
Published: November 2018

Today, the possibility of amplifying the signal of Raman scattering is intensively studied in order to realize a simple and reliable tool for monitoring of ultra-small concentrations of chemical and biological substances. Plasmon-active nanostructures can serve as the basic element of substrates for signal amplifying, and the degree of amplification is determined by nanostructures size and shape. The formation of nanostructures with a predetermined morphology requires the development of new approaches. In this concern, the paper considers a complex approach of plasmon-active silver nanostructures with a wide range of shapes and sizes formation in the pores of ion-track Sio2templates on silicon. The peculiarities of SiO2templates creation are considered and the etching rates, uniquely determining the parameters of the pores as a function of the etching time, are established. The features of the silver nanostructures formation in the pores of the SiO2template are described for various pore sizes and synthesis regimes (time and solution temperature). The possibility of formation of nanostructures with different shapes as well as evolution of their morphology with variation of synthesis parameters is shown. on the example of dendrites, having a high potential for practical application for amplification of the Raman scattering signal, the possibility of recording Raman spectra was demonstrated using the model analyzer Nile Blue at the concentration of 10-6M/l. The results indicate that plasmon-active silver nanostructures in the pores of ion-track Si02template on silicon can be used as basic element of biosensors to studying ultra-low doses of chemical and biological substances.

Communicated by Corresponding Member Valery M. Fedosyuk
Formalization of the process and development of an algorithm for solid-phase mixing of components of a heterogeneous composite material
Authors: Ilyushchanka A. Ph. , Buloichyk V. M. , Kryvanos A. K. , Piatsiushyk Ya. Ya.
Published: November 2018

The article considers one of the approaches to modeling the process of mixing of polydisperse powders, which includes three main fractions of different sizes, the shape of which is close to spherical. The work is aimed at reducing material costs at the stage of development of mixing processes by reducing the number of experiments. Aiming to obtain the most uniform mixing with the minimum time of the technological process, the model is based on the target function for a certain number of iterations of mixing of the composition to obtain the required (maximum possible) density of the package of mixed solid particles.

To develop a model of the mixing process, one of the heuristic algorithms – the “metal annealing method” – was used. As a representative element of the model, an elementary cell in the form of several hexagonal densely. Packed particles around one introduced into the composition of the composite material (in a small amount, from 5 to 15 %) as a modifier was adopted. The mo del is formalized with the condition of averaging the particle sizes within each fraction, as well as the morphology of their surface. The number of particle repackaging iterations is calculated by the probability of obtaining the minimum amount of voids in the representative element and the uniformity of distribution of the modifying element.

Comparison of the values obtained during the simulation with the measured values of the mixing results on a specific mixer will form a scale of compliance of the simulation results with the operating modes of the process equipment. This will make it possible to predict the appropriate mixing modes at the stage of development of the technological process with the possible system of fluctuations in the characteristics of the supplied raw materials and, thereby, to create a methodological basis for the formation of quality management of manufacturing heterogeneous composite material. The model can be adapted for polydisperse powders with the content of the main fractions of more than three.
Investigation of tunable gyrotron on a cone-shaped waveguide
Authors: Kolosov S. V. , Zapevalov V. E. , Zaitseva I. E.
Published: November 2018

The results of calculations of a nonlinear model of a tunable frequency gyrotron on a cone-shaped waveguide and the main wave TE01 are presented. It is shown that the adjustment range can reach 2.8 %. To extend this band, it is necessary to lengthen the cone-shaped part of the waveguide without changing the angle of increase in the radius of the waveguide.

The wave efficiency of a waveguide expanding along the axis is 21 % at a working frequency of 10 GHz. To achieve these parameters, it is necessary to divide the gyrotron electromagnet into two parts – the main electromagnet and auxiliary one, which has a limited length and can move along the waveguide. The second magnet can be made in the form of a set of individual electromagnets of limited length the set of electromagnets must fill the entire length of the cone-shaped waveguide. The fulfillment of this condition will allow to move the resonant magnetostatic field along the waveguide by switching the current in the coils of this set of electromagnets, which will exclude the mechanical movement of the auxiliary electromagnet. At a frequency of 200 GHz, the wave efficiency is reduced to 15 %, while the ohmic losses in the walls of the waveguide are 3 % of the power of the electron beam.

The dependence of the gyrotron efficiency on the initial angular spread of electron velocities was investigated. It was concluded that the initial angular spread of the electron velocities has very little effect on the efficiency of the tunable gyrotron.

The wave efficiency of a waveguide narrowing in length can reach 29 % at a frequency of 200 GHz, ohmic losses in the walls of a copper waveguide amount to 4 % of the power of the electron beam. Calculations have shown that a lamp backward wave gyrotron with a waveguide narrowing along the axis is more efficient than the version of the gyrotron traveling wave tube. However, in both cases, the synchronous value of the magnetostatic field must be displaced along the axis, depending on the required operating frequency, otherwise there occurs either a rearrangement of the electron beam or a return of the energy to the high-frequency field by the electron beam.
Breeding and problems of cultivation of winter rye F1 heterosis hybrids in the Republic of Belarus
Authors: Urban E. P , Gordei S. I.
Published: November 2018

Reserves of heterosis breeding with efficiency undoubtedly higher, have not been fully applied regarding winter rye crop in Belarus, therefore the creation of heterosis F1 hybrids of winter rye is currently a priority research area in the Republic of Belarus. The paper dwells on the main results of rye breeding for heterosis, discusses the problems of growing hybrid rye varieties in agricultural production. Thus, the first experimental line-population F1 hybrids of winter diploid rye were developed at RUE “Scientific and Practical Centre of Belorussian NAS for Arable Farming”: Lobel-103, Galinka, Plisa and interline hybrid Belgi which in the competitive variety test exceeded the standard by 8.0–14.4 dt/ha. F1 winter rye hybrids form more high stem density by the time of harvesting, which provides higher yields compared with the standard. As a result of breeding experiments on the genetic basis of the Belarusian highly adaptive populations, CMS systems with high combining ability have been created. It was shown that R-type CMS is characterized by high frequency of sterility fixation genes, and therefore there are no problems with maintaining MS-forms in generations. More labor-intensive process is allocation of fertility restorers with a high restore index and with a high combination capacity at the same time. Problems in the cultivation of hybrid varieties of rye associated with a number of genetic and soil-climatic causes were revealed.
Mechanization of field drying herbs: ways improvement
Authors: Kazakevich P. P. , Yakovchik S. G. , Labotsky I. M. , Traphimovich L. I.
Published: November 2018

High-quality grass feeds (hay, haylage, silage) decrease cost price, improve consumer properties and increase competitiveness of cattle products significantly being the main component of agricultural export for the Republic of Belarus. An important issue of grass feed procurement is acceleration of mowed grass drying process. Reduction of drying time or drying process acceleration has a positive effect on feed quality. To achieve this goal, technique of laying the mowed grass on stubble, in rolls or spreading, turning and conditioning is applied. Based on practical experience of application and analysis, the relevance of repeated rolling (reconditioning) of mowed grasses in rolls is substantiated. Design and workflow of new device for such grass rolling has been developed. Its working unit is designed as a sawn-deck or roller flatting apparatus. The kinematic parameters of the upper and lower rollers have been determined experimentally: the rollers rotation ratio should make 1.01 m ωв / ωн m 1.03. Field tests of the device with legumes helped to determined that it accelerates drying by 15–20%, reduces protein loss by 10–15% compared to drying with no treatment. The presented research materials present the development of the theory of grass feeds procurement mechanization. Use of the materials in practice will improve the quality of grass feeds by accelerating the mowed grass drying process.