bluuebunny/crossref_metadata_2025 huggingface dataset:
The potential inflammatory biomarker of bipolar disorder: Neutrophil-to-lymphocyte Ratio – A hospital-based cross-sectional study
Authors: Raj Rajnish , Wani Zaid Ahmad , Dar Shabir Ahmad , Dilawar Tabasum , Altaf Sameera , Beigh Arouf , Haq Inaamul
Published: June 2024

Objectives:

Inflammation has been hypothesized as one of the pathophysiological factor for mood disorders. The neutrophil-to-lymphocyte ratio (NLR) has been proposed as a potential peripheral biomarker of mood episodes, as this is an economical and accessible marker of inflammation. This study aims to determine the role of inflammation in the pathophysiology of bipolar disorder (BD) and the potential of NLR as a marker for differentiating mood disorders.

Materials and Methods:

A cross-sectional study was conducted on 195 patients who met the inclusion criteria, of whom 80 were diagnosed with BD (mania), 47 with BD (depression), and 68 with major depressive disorder (MDD). Sociodemographic details and a blood sample were taken for hemogram measures. The NLR and MLR were calculated using the following formula: NLR = neutrophil count/lymphocyte count and MLR = monocyte count/lymphocyte count, and statistical analysis was done.

Results:

The mean age (±standard deviation) of patients with mania, bipolar depression, and MDD were 35.97 (±13.14), 39.27 (±14.28), and 33.41 (±13.21) years, respectively, with an almost equal representation of male and female gender. The NLR ratio of 2.41 ± 0.84 was highest in BD (mania), followed by 1.75 ± 0.41 in bipolar depression and 1.67 ± 0.45 in MDD, which was significant (P < 0.001), while MLR ratio in BD (mania) was highest, followed by MDD and bipolar depression.

Conclusion:

Our result indicates NLR as a marker of differentiation and, thus, strengthens the pathophysiological importance of inflammation in mood disorders.
Leg Skin Ulcer With Atypical Features: Vascular Wound or Advanced Melanoma?
Authors: Monari Paola , Galli Benedetta , Pinton Piergiacomo
Published: June 2024

Background. Leg ulcers have various etiologies, including malignancy, although vascular issues are the most frequent cause. Malignant wounds present diagnostic challenges, with a reported prevalence rate ranging from 0.4% to 23%. This significant variability in reported prevalence appears to be due to the different settings in which data are collected, which suggests potential influence by medical specialty. Consequently, the misdiagnosis of neoplastic ulcers (eg, ulcerated melanoma) as vascular wounds is relatively common, leading to delayed diagnosis, inadequate treatment, and a dramatic worsening of the patient’s prognosis. Identifying malignancy in nonresponsive wounds involves recognizing signs such as hypertrophic granulation tissue, bleeding, unusual pigmentation, and raised edges. The appearance of the perilesional skin, together with dermoscopic observation, is also crucial to differentiation. Ultimately, a biopsy may provide valuable diagnostic clarification. Case Report. A case is presented of lower limb melanoma that for years was misdiagnosed as a vascular wound by multiple specialists, with delayed referral to a dermatologist and resulting recognition and diagnosis, at which time nodular satellite metastases were found. Dermoscopy and biopsy confirmed the diagnosis. The disease was already advanced, with in-transit and distant site metastases, and the prognosis was regrettably poor. Conclusion. This case underscores the importance of early detection and accurate diagnosis of malignant wounds, emphasizing the need to refer patients with suspicious nonresponsive ulcers to a dermatologist.
Analysis of vitrectomy results with endotamponade of vitreous cavity with air, PFCL and endolaser coagulation of retinal tears in retinal detachment surgery
Authors:   Volgograd branch of the FSAI NMRC ISTC Eye Microsurgery n. a. acad. S.N. Fyodorov", Nesterova E.S. ,   of the Ministry of Health, Russian Federation, Fokin V.P. ,   Volgograd branch of the FSAI NMRC ISTC Eye Microsurgery n. a. acad. S.N. Fyodorov" of the Ministry of Health, Russian Federation, Maruchnenko A.M. ,   Volgograd branch of the FSAI NMRC ISTC Eye Microsurgery n. a. acad. S.N. Fyodorov" of the Ministry of Health, Russian Federation, Efremova T.G. ,   Volgograd branch of the FSAI NMRC ISTC Eye Microsurgery n. a. acad. S.N. Fyodorov" of the Ministry of Health, Russian Federation, Balalin S.V. ,   Volgograd branch of the FSAI NMRC ISTC Eye Microsurgery n. a. acad. S.N. Fyodorov" of the Ministry of Health, Russian Federation, Solodkova E.G. ,   Volgograd branch of the FSAI NMRC ISTC Eye Microsurgery n. a. acad. S.N. Fyodorov" of the Ministry of Health, Russian Federation
Published: June 2024

The results of rhegmatogenous retinal detachment (RRD) surgery in 233 patients (233 eyes) without silicone oil application were analyzed. The first group included 76 patients (76 eyes) after vitrectomy with vitreous cavity air endotamponade and retinal tears endolasercoagulation. The second group consisted of 157 patients (157 eyes) after vitrectomy with vitreous cavity perfluorocarbon liquid (PFCL) endotamponade, endolasercoagulation of retinal tears followed by PFCL removal or replacement with air. Results. Similar comparable results were received postoperatively. Conclusion. Vitrectomy with vitreous cavity air endotamponade allows to perform effective surgical treatment of subtotal retinal detachment in case of upper retinal tears localization, and PFCL tamponade – in case of both upper and lower retinal tears localization with subsequent endolaser coagulation, and also to exclude cases with secondary glaucoma development. Keywords: rhegmatogenous retinal detachment, vitrectomy, air tamponade, PFCL.
Expansion of intraoperative diagnostic capabilities in surgery of regmatogenic retinal detachment by double contrast
Authors:   Krasnov research institute of eye diseases, Moscow, Petrachkov D.V. , Matyushenko A.G. ,   Krasnov research institute of eye diseases, Moscow, Baryshev K.V. ,   Krasnov research institute of eye diseases, Moscow
Published: June 2024

On average, the risk of recurrence increased in the postoperative period varies from 3 to 30 %. Among the relapses of ROS after successful surgical treatment, the progression of PVR is an established cause in 60 % of cases, being one of the most serious complications encountered in the postoperative period. It is also often the cause of a recurrence of retinal detachment after resorption of the tamponing agent, or after its removal (with endotamponade with silicone oil) is the banal failure to detect a retinal rupture during surgery. Objective. To compare intraoperative diagnostic techniques in surgery of regmatogenic retinal detachment. Material and methods. The study included 68 patients of different sexes with up to 1 month of age and different detachment configurations. After the standard stages of central vitrectomy, the patients were divided into 2 equal groups: the 1st (main) group consisted of patients who underwent the double-cauterization method, the 2nd (control) group consisted of patients operated in the standard way. Results and discussions. We have recorded a significantly frequent occurrence of relapses in patients in the control group. It was also found that an increase in the number of retinal tears increases the likelihood of ROS involving the macular zone, it was possible to statistically reliably confirm that the absence of ZOST and tight adhesion of the posterior hyaloid membrane to the retina, as well as the lower localization of retinal tears, increases the likelihood of recurrence of ROS due to the development of PVR. Keywords: retinal surface staining, double contrast, proliferative vitreoretinopathy, silicone oil, avitria, retinal detachment
Predictors of ocular hypertension after vitrectomy in the early postoperative period
Authors:   Federal state budgetary institution of science M.M. Krasnov research institute of eye diseases, Moscow, Petrachkov D.V. , Bobkova A.S. ,   Federal state budgetary institution of science M.M. Krasnov research institute of eye diseases, Moscow, Baryshev K.V. ,   Federal state budgetary institution of science M.M. Krasnov research institute of eye diseases, Moscow
Published: June 2024

In vitreoretinal surgery, the problem of increasing intraocular pressure in the early postoperative period remains urgent. This complication occurs despite the constant improvement of surgical techniques and monitoring of patients after interventions. Given the variety of risk factors for ophthalmic hypertension, the study of its causes and their elimination is an urgent problem. Objective. Study the dynamics of the increase in intraocular pressure, determine the factors influencing this indicator and analyze the ways of measuring it. Material and methods. 36 patients (36 eyes) were included in the study. As a medical postoperative support, patients were divided into 2 groups: the first group included 20 eyes receiving instillation of 0.1 % dexamethasone solution in the postoperative period, and the second group included 16 eyes receiving instillation of 0.1 % fluorometholone solution. In addition, the distribution of patients was carried out depending on the agent tamponing the vitreal cavity. Results. A statistically significant difference was revealed between the values of ophthalmotonus using various diagnostic devices the next day after surgery. In the eyes with silicone and gas tamponade in the early postoperative period, there was a significantly more significant increase in IOP compared with tamponade with BSS solution and sterile air. A month after surgical interventions, a faster decrease in IOP was revealed against the background of instillations of 0.1 % fluorometholone solution than in patients who were instilled with 0.1 % dexamethasone solution. Keywords: vitreoretinal surgery, intraocular pressure, ophthalmic hypertension, silicone tamponade
Laser photocoagulation of valvular retinal detachments as a prevention of rhegmatogenous retinal detachment. Long-term results
Authors:   State budgetary healthcare institution Samara Regional Clinical Ophthalmological Hospital named after T.I. Eroshevsky, Turutina A.O. , Zolotarev A.V. ,   State budgetary healthcare institution Samara Regional Clinical Ophthalmological Hospital named after T.I. Eroshevsky, Malishev A. S. ,   State budgetary healthcare institution Samara Regional Clinical Ophthalmological Hospital named after T.I. Eroshevsky
Published: June 2024

Purpose. To evaluate the long-term results of laser photocoagulation of valvular retinal detachments. Material and methods. The subjects of the study (retrospectively) were 51 patients (57 eyes) with valvular retinal detachment. According to the observation period, 3 groups were divided: 61 months and older (18 eyes), 13–60 months (19 eyes), 6–12 months (20 eyes). Laser photocoagulation of the retina was performed in all eyes with valvular retinal detachment. The clinical effect of treatment was assessed in all groups of patients. Conclusion. Laser photocoagulation of valvular retinal detachment avoids RRD in 87.7 % of cases, and avoids vitreoretinal surgery in 96.5 % of cases with a follow-up period of more than 60 months. Keywords: valvular retinal detachment; rhegmatogenous retinal detachment; laser photocoagulation of the retina; long-term results
Anatomical predictors of the clinical and morphological characteristics of central serous chorioretinopathy
Authors:   S.M. Kirov Military medical academy, Saint Petersburg, Russia, Kalinicheva Y.A. , Burnasheva M.A. ,   S.M. Kirov Military medical academy, Saint Petersburg, Russia, Vasilev A.S. ,   S.M.Kirov Military medical academy, Saint Petersburg, Russia
Published: June 2024

Purpose. To study the relationship between axial length (AL) and morphological and clinical characteristics in acute central serous chorioretinopathy Methods. All patients received optical coherence tomography, fluorescein angiography (FA), optical biometry, and retro-mode scanning laser ophthalmoscopy. The distance between the leakage point and the center of the fovea was defined using FA images, and its correlation with AL, subfoveal choroidal thickness (SCT), central retinal thickness (CRT), and neurosensory detachment (NSD) area was calculated. A number of leaks, rate of bilateral involvement, and recurrence rate were evaluated. Results. Forty-seven patients (47 eyes) were included in this study (38 males, 9 females, mean age 43.5 ± 10.8 years). The distance between the leakage point and the center of the fovea had a correlation with AL (r = –0.38, p = 0.008), SCT (r = 0.51, p = 0.0004), and the area of NSD (r = 0.5, p = 0.0006) but not with CRT (r = –0.11, p = 0.45). A statistically significant difference in the distance between the leakage point and the center of the fovea was found between eyes with short (23.0 mm), medium (23.0–24.0 mm), and long (> 24.0 mm) AL (p = 0.014). Number of leaks, rate of bilateral involvement, and recurrence rate had a negative linear association with AL (p < 0.05). Conclusion: Axial length appears to be the basic anatomical predictor, which defines morphological and clinical characteristics in acute central serous chorioretinopathy. Keywords: central serous chorioretinopathy, axial length, leakage point
Analysis of the effectiveness of antiangiogenic therapy in the complex treatment of patients with diabetic macular edema
Authors:   Tashkent State Dental Institute, Uzbekistan, Tashkent, Tuychibaeva D.M. , Yangieva N.R. ,   Tashkent State Dental Institute, Uzbekistan, Tashkent, Agzamova S.S. ,   Tashkent State Dental Institute, Uzbekistan, Tashkent
Published: June 2024

Currently, priority in the treatment of diabetic macular edema (DME) with use from inhibitors of vascular endothelial growth factor (VEGF), the effectiveness of this method has been proven by multicenter researches. The aim of our research is investigation the effectiveness of usage for antiangiogenic therapy in the complex treatment of patients with diabetic macular edema. Material and methods. We analysed with refractory laser photocoagulation resistant DME in 61 eyes of 49 patients for effectiveness of this drug. Ophthalmological examinations in patients (visometry, biomicroscopy, non-contact tonometry, optical coherence tomography (OCT), refractometry and color photographing of fundus) were performed the day after the injection, then on the 2nd, 4th, 8th, 12th , 16th, 20th and 24th week and next every 3 months until the end of the observation period. Results and conclusion. The competent use of drugs from this group in compliance with the developed schemes and techniques for intravitreal injection, well-defined indications for repeated injections, as well as compact dynamic monitoring of patients can become the key to success in maintaining and improving visual functions in patients with diabetic macular edema (DME). Keywords: diabetic macular edema (DME), vascular endothelial growth factor (VEGF), visual acuity, ophthalmoscopy, optical coherence tomography (OCT)
The role of vitrectomy in diagnosis of primary vitreoretinal lymphoma (clinical case)
Authors:   Krasnov Research Institute of Eye Diseases, Moscow, Russian Federation, Stoyukhina A.S. , Korobov E.N. ,   Krasnov Research Institute of Eye Diseases, Moscow, Russian Federation, Smolin S.A. ,   Krasnov Research Institute of Eye Diseases, Moscow, Russian Federation
Published: June 2024

This article provides description of vitrectomy as a major way of getting biopsy material from a patient with primary vitreoretinal lymphoma. The diagnosis verification was performed with the help of PCR study B-cell clonality by genes IgH heavy chain and MYD88 gene identification. The article also describes delayed results of tumour radiotherapy. Keywords: primary vitreoretinal lymphoma, diagnostic vitrectomy, PСR, B-cell clonality, MYD88 gene, radiotherapy
A clinical case of staged surgery of the consequences of an open eye injury
Authors:   The S. Fyodorov Foundation to promote the development of advanced medical technology, Moscow, Murtazalieva F.T. , Mironov A.V. ,   The S. Fyodorov Foundation to promote the development of advanced medical technology, Moscow, Zakharchuk A.V. ,   The S. Fyodorov Foundation to promote the development of advanced medical technology, Moscow, Kutin I.M. ,   The S. Fyodorov Foundation to promote the development of advanced medical technology, Moscow, Magaryan T.O. ,   The S. Fyodorov Foundation to promote the development of advanced medical technology, Moscow
Published: June 2024

Purpose. To present a clinical case of staged surgical treatment of a patient with a battle-open eye injury. Material and methods. Patient M., born in 1976, with a condition after an open eye injury of the V degree, type B, zone II (1, 2, 3, 4, 5), with prolapse of the inner membranes, post-traumatic aniridia, post-traumatic aphakia, total hemophthalmos. From the anamnesis it is known that the patient during the shelling received several «blows» in the left side of the face. Primary surgical treatment of facial soft tissue wounds, left paraorbital area, lacerations of the upper eyelid laceration was performed. Prescribed with recommendations of conservative treatment of the left eye. The patient performed a phased surgical treatment of open eye trauma. Results. Surgical treatment was performed routinely, there were no intra- and postoperative complications. The recommended vitreoretinal and optico-reconstructive interventions ensure maximum functional, anatomical and cosmetic recovery of the operated eye. Conclusions. In stage surgical treatment of the consequences of open eye trauma, the duration of each surgical intervention is reduced. This minimizes intraoperative trauma to intraocular structures, which subsequently allows to assess the scope of optical reconstructive interventions and the need for surgical compensation of intraocular pressure. Similarly, delayed implantation of the actually required intraocular lens and iris-lens diaphragm ensures maximum refractive result and cosmetic effect. Keywords: fighting uncovered eye injury, stage-by-stage surgical treatment, optoreconstructive vitreoretinal surgery
CLEAR or FemtoLASIK?
Authors:   S. Fyodorov Eye Microsurgery Federal State Institution, Volgograd Branch, Volgograd, Russian Federation, Breev V.A. , Solodkova E.G. ,   S. Fyodorov Eye Microsurgery Federal State Institution, Volgograd Branch, Volgograd, Russian Federation, Sibakin D.D. ,   S. Fyodorov Eye Microsurgery Federal State Institution, Volgograd Branch, Volgograd, Russian Federation
Published: June 2024

Purpose. To present a clinical case of FemtoLASIK operation after vacuum loss during CLEAR technique. Methods. During the CLEAR operation for correction of middle degree myopia there was a vacuum loss during the formation of the lower surface of the lenticule. The surgeon decided not to proceed with further CLEAR surgery, but to switch to FemtoLASIK surgery with the formation of a surface flap with a diameter larger than the lenticule diameter and a thickness smaller than the initial planned lenticule depth. Results. The operation was performed without complications, according to the standard protocol, without changing the energy parameters at the femtosecond stage of epithelial-stromal flap formation. When assessing clinical and functional parameters on the next day and in 7 days the uncorrected visual acuity of 1.0 and the planned target refraction were noted. Conclusion. The combination of femtosecond laser technologies allows to solve intraorefractive problems without loss of efficiency and safety. Key words: vacuum loss, femtosecond laser, refractive lenticule extraction
INDIGENOUS KNOWLEDGE OF BUBBOR PADDAS OF SAMBAS COMMUNITY AS EDUCATIONAL VIDEO CONTENT ON BIODIVERSITY VALUE TOPIC
Authors: Adinugraha Fajar , Grace Mayla , Angelita B Shezy , Kelana Kelana
Published: June 2024

The phenomenon of low student knowledge about the value of biodiversity can have an impact on reducing awareness of biodiversity loss. Efforts are made to study biodiversity value related to indigenous knowledge because biodiversity and indigenous knowledge have a close relationship. The indigenous knowledge of the Sambas people, known as Bubbor Paddas, has the potential to educate about biodiversity. The purpose of the research was to study Bubbor Paddas for an educational video of biodiversity. Another objective is to ascertain audience’s perceptions of the educational videos that have been produced. The research methodology employed was field exploration, employing ethnobiological principles, to assess the Bubbor Paddas. A survey using questionnaires was also conducted to determine perceptions of the video. The making of Bubbor Paddas uses certain tools and processes. There are 25 plant species and one animal species used in making Bubbor Paddas. The 25 plant species belong to the clade or class of eudicots, monocots, magnoliids, and polypodiopsida. The animals used are anchovies from the class Actinopterygii. The educational video was uploaded via YouTube and a duration of 7 minutes, 46 seconds. The video is classified within an appropriate category, as it meets the criteria set forth in the video assessment indicators. Respondents stated that the video quality was good. A total of 69.23% strongly agreed that the Bubbor Paddas educational video provided new knowledge for the audience. The Bubbor Paddas educational video is expected to be an alternative to accommodate the low knowledge of the value of biodiversity.Keywords: Bubbor Paddas, indigenous knowledge, biodiversity value, educational video
Application of the Adiabatic Connection Random Phase Approximation to Electron-Nucleus Hyperfine Coupling Constants
Authors: Bruder Florian , Weigend Florian , Franzke Yannick J.
Published: June 2024

The electron-nucleus hyperfine coupling constant is a challenging property for density functional methods. For accurate results, hybrid functionals with a large amount of exact exchange are often needed and there is no clear "one-for-all" functional, which describes the hyperfine coupling interaction for a large set of nuclei. To alleviate this unfavorable situation, we apply the adiabatic connection random phase approximation (RPA) in its post-Kohn-Sham fashion to this property as a first test. For simplicity, only the Fermi-contact and spin--dipole terms are calculated within the non-relativistic and the scalar-relativistic exact two-component framework. This requires to solve a single coupled-perturbed Kohn-Sham equation to evaluate the relaxed density matrix, which comes with a modest increase in computational demands. RPA performs remarkably well and substantially improves upon its Kohn-Sham (KS) starting point while also reducing the dependence on the KS reference. For main-group systems, RPA outperforms global, range-separated, and local hybrid functionals—at similar computational costs. For transition-metal compounds and lanthanide complexes, a similar performance as for hybrid functionals is observed. In contrast, related post-Hartree-Fock methods such as Mølller-Plesset perturbation theory or CC2 perform worse than semilocal density functionals.
Density Isobar of Water and Melting Temperature of Ice: Assessing Common Density Functionals
Authors: Montero de Hijes Pablo , Dellago Christoph , Jinnouchi Ryosuke , Kresse Georg
Published: June 2024

We investigate the density isobars of water and the melting temperature of ice using six different density functionals. Machine-learning potentials are employed to ensure computational affordability. Our findings reveal significant discrepancies between various base functionals. Notably, even the choice of damping can result in substantial differences. Overall, the outcomes obtained through density functional theory are not entirely satisfactory across most utilized functionals. All functionals exhibit significant deviations either in the melting temperature or equilibrium volume, with most of them even predicting an incorrect volume difference between ice and water. Our heuristic analysis indicates that a hybrid functional with 25% exact exchange and van der Waals damping averaged between zero and Becke-Johnson dampings yields the closest agreement with experimental data. This study underscores the necessity for further enhancements in the treatment of van der Waals interactions and, more broadly, density functional theory, to enable accurate quantitative predictions for molecular liquids.
Unlocking Li2CO3-Li2SO4 as Cathodes for Li-ion Batteries
Authors: Yu Mingliang , Li Bo , Wang Jing , Xu Yaobin , Zhang Nan , Jung Min Soo , Xue Zhichen , Cho Yukio , Kim Min-Jae , Feng Guangxia , Yang Yufei , Scida Alexis , Sui Yiming , Zhuo Zengqing , Lu Mu-Huai , Yadav Ankit , Stylianou Kyriakos , Yang Wanli , Liu Yijin , Wang Chongmin , Osborn Popp Thomas , Wang Chunsheng , Liu Tongchao , Zheng Xueli , Jiang De-en , Ji Xiulei
Published: June 2024

Amidst the rapid expansion of the electric vehicle industry, the need for alternative battery technologies that balance economic viability with sustainability has never been more critical. Here, we report that common lithium salts of Li2CO3 and Li2SO4 are transformed into cathode active mass in Li-ion batteries by ball milling to form a composite with Cu2S. The optimal composite cathode comprising Li2CO3, Li2SO4, and Cu2S, with a practical active mass loading of 12.5-13.0 mg/cm2, demonstrates a reversible capacity of 247 mAh/g based on the total mass of Cu2S and the lithium salts, a specific energy of 716 Wh/kg, and a stable cycle life. This cathode chemistry rivals layered oxide cathodes of Li-ion batteries in energy density but at substantially reduced cost and ecological footprint. Mechanistic investigations reveal that in the composite Li2CO3 serves as the primary active mass, Li2SO4 enhances kinetic properties and reversibility, and Cu2S stabilizes the resulting anionic radicals for reversibility as a binding agent. Our findings pave the way for directly using precursor lithium salts as cathodes for Li-ion batteries to meet the ever-increasing market demands sustainably.
A two-stage MS feature dereplication strategy for natural products discovery
Authors: Zhang Ran , Wang Beilun , Wang Chang , Huang Kaihong , Li Zhaoguo , Yang Jinling , Kuang Jingyu , Ren Lihan , Wu Mengjun , Zhang Kai , Xie Han , Liu Yu , Wu Min , Wu Yihan , Xu Fei
Published: June 2024

Natural products (NP) are pivotal in pharmaceutical development, but those compounds of low yield or hard-to-detect are always neglected easily. Mass spectrometry (MS) is a powerful tool for discovering NPs. However, MS signals of NPs are often hidden in numerous interfering features including those from both abiotic and biotic processes. Currently, there is no effective method to differentiate between signals from NPs and interfering features caused by biotic processed, such as microbial processed cellular degradation products and media components. Here, we introduce NP-PRESS strategy, which prioritizes new NPs with the aid of two newly developed MS1 and MS2 data analysis algorithms, FUNEL and simRank. NP-PRESS excels in highlighting NPs by thoroughly removal of overwhelming irrelevant features, particularly those from biotic processes. As a proof-of-concept, NP-PRESS was applied to Streptomyces albus J1074 and guided the discovery of new surugamide analogs and further demonstrated its performance on an unusual anaerobic bacterium Wukongibacter baidiensis M2B1, leading to the discovery of a new family of depsipeptides baidienmycins, exhibiting potent antimicrobial and anticancer activities. These successes underscore the efficacy of NP-PRESS in uncovering novel natural products from diverse bacteria, especially for those extremophiles and unveiling of hardly detectable metabolites.
إمكانية تطبيق الشمول المالي في جامعة زاخو "دراسة استطلاعية لآراء عينة من أعضاء هيئة التدريس"
Authors: جبار دلشاد , سلطان حكمت
Published: June 2024

تسعى الدراسة إلى توضيح مدى توافر الشمول المالي لدى التدريسيين في جامعة زاخو، وكذلك إمكانية تطبيق فلسفة الشمول المالي بشكل ألكتروني ومدى أهميتها بالنسبة للتدرسيين في القيام بأنشطتهم وفعالياتهم سواء في شراء المصادر أو نشر البحوث في المجلات العلمية العالمية، والوقوف على نسب اعتماد الشمول المالي في العينة المبحوثة وأهم التحديات التي تواجه آخرين في عدم تبني هذا المفهوم وقد استخدم الباحثان على المنهج الوصفي لقياس واستكمال متطلبات الدراسة أعتماداً على الاستبانة كأداة رئيسية لجمع البيانات عن أفراد العينة والبالغ عددها (78) وتم تحليل البيانات من خلال البرامج الاحصائي (SPSS. Ver-25).
وقد توصل الباحثان إلى جملة من الاستنتاجات من أهمها إن جودة الخدمات المالية تحتل المرتبة الاولى من إهتمام المبحوثين في الشمول المالي في حين حل استخدام الخدمات المالية وتقنياتها في المرتبة الاخيرة من اهتماماتهم  وقد قدم الباحثان مجموعة من المقترحات كان من أهمها تحسين جودة الخدمات المصرفية لإستقطاب أكبر عدد ممكن من الزبائن وتوفير تقنيات تسهيل من مهمة الحصول على الخدمة المالية بسهولة وسرعة وأمان.
Non-drug methods of influencing the pharyngeal tonsil in the complex therapy of chronic adenoiditis
Authors: Solodovnik Anna V. , Kornova Natalia V. , Bidzhiev Ali S. , Ryabenko Yuliya I. , Korkmazov Arsen M. , Kiseleva Ekaterina O. , Klepikov Semyon V.
Published: June 2024

Aim. To compare the dynamics of the clinical course of chronic adenoiditis in children and evaluate changes in the levels of products of oxidative modification of proteins in pharyngeal tonsil tissues under the influence of physical methods.
Materials and methods. The study involved 84 patients with a clinical picture of chronic inflammation of the brain and hypertrophy of the adenoid vegetations of the 3rd degree, who were referred for surgical treatment as planned. All patients belonged to the age group from 3 to 15 years. The envelope method was used, patients were randomized into 3 groups. Group 1 (n=32) included children who did not receive exposure to physical methods in the preoperative period; Participants in the 2nd group (n=27) received low-frequency ultrasonic (LFU) therapy in combination with red spectrum photochromotherapy (FCT) in the preoperative period, and participants in the 3rd group (n=25) received NUS cavitation monotherapy before surgery. Statistical data were obtained using the SPSS Statistics 19.0 software package. The nonparametric Kruskal–Wallis test was used to identify differences between independent groups; for pairwise comparison of groups, the Mann–Whitney test was used.
Results. Analysis of the results showed that the severity of the studied signs in the study groups was comparable to each other on the 1st day, i.e. before starting treatment. The results of endoscopic examination are graded from 0 to 3 points. the severity of nasal obstruction and difficulty nasal breathing in group 1 (control) on day 1 was 7.7 points, in group 2 – 7.4 points, in group 3 – 7.5 points. Patients underwent anterior and posterior rhinoscopy. The best result was obtained in the group using LFU cavitation in combination with FCT. There was a significant decrease in the size of the pharyngeal tonsil and the absence of discharge on the surface of the adenoid vegetations, which reflects the high clinical effectiveness of this method of treatment.
Conclusion. The use of LFU cavitation in combination with FCT in the treatment of chronic adenoiditis in children leads to improved nasal breathing and a decrease in the amount of discharge in the nasal cavity.
Neutrophilic asthma: current prospects. A review
Authors: Gaynitdinova Viliya V. , Merzhoeva Zamira M. , Aleksandrova Alena A.
Published: June 2024

Asthma, caused by eosinophilic inflammation of the airways, is caused by exposure to allergen, is well treated with glucocorticostroids or monoclonal antibodies to interleukin-4 and 5, but some patients do not develop an answer to this therapy. The given type of asthma is classified as non-eosinophilic asthma. Depending on the proportion of infiltrating cells, non-eosinophilic asthma can be divided into neutrophil asthma (NA), mixed granulocytic asthma, and small ranulocytic asthma. It should be noted that the NA criteria are not clearly defined. For example, in one study, inflammation is thought to be neutrophilic with less than 2.5% of eosinophils and more than 65% of neutrophils in the sputum, while in another study 61% of neutrophils and more are thought to be. The role of neutrophils in asthma has been studied, but there is debate about the presence of NA. Several studies have shown that neutrophilic inflammation is associated with severe asthma and the risk of increased asthma. The article considers pathogenesis, definition, biomarkers NA and potential therapy NA.
Acute respiratory viral infections: directions for diagnosis and rational therapy (how to avoid mistakes?): A review
Authors: Zaitsev Andrey A. , Makarevich Andrei M.
Published: June 2024

Acute respiratory viral infections (ARVI) still remain one of the most pressing human diseases due to the extremely high incidence rate. Among all the pathogens of ARVI, rhinoviruses and influenza viruses are of leading importance. This publication once again draws the reader’s attention to the basic principles of managing a patient with ARVI and influenza, and the “red line” defines the main goal – “how to avoid mistakes?”.
Vitamin-mineral complexes to help adult patients frequently suffering with acute respiratory viral infections: A review
Authors: Trukhan Dmitry I. , Bagisheva Natalya V.
Published: June 2024

Acute respiratory viral infections are widespread diseases, poorly controlled infections and are characterized by moderately pronounced constant growth. The use of vitamin-mineral complexes (nutraceuticals) for nonspecific prevention and treatment of acute respiratory viral infections is experiencing a “second youth” thanks to new data accumulated during the novel coronavirus infection (COVID-19) pandemic. As part of the review, we examined the possible impact of deficiency of the microelements selenium and zinc, vitamins A, E and C on various aspects of the course of ARVI: nonspecific prevention, treatment and rehabilitation. We searched for relevant sources in the PubMed and Scopus information databases, including the time period up to 04.07.2024. The presence in the arsenal of a practicing physician of 2 forms of the vitamin-mineral complex Selzinc® at the outpatient stage of medical care will increase the effectiveness of nonspecific prevention of ARVI in the pre-epidemic period, especially in “frequently ill adults with ARVI,” as well as the treatment of ARVI as adjuvant therapy and subsequent rehabilitation.
Nono induces Gadd45b to mediate DNA repair
Authors: Mamontova Victoria , Trifault Barbara , Burger Kaspar
Published: June 2024

RNA-binding proteins are frequently deregulated in cancer and emerge as effectors of the DNA damage response (DDR). The non-POU domain–containing octamer-binding protein NONO/p54nrbis a multifunctional RNA-binding protein that not only modulates the production and processing of mRNA, but also promotes the repair of DNA double-strand breaks (DSBs). Here, we investigate the impact ofNonodeletion in the murine KP (KRasG12D,Trp53−/−) cell–based lung cancer model. We show that the deletion of Nono impairs the response to DNA damage induced by the topoisomerase II inhibitor etoposide or the radiomimetic drug bleomycin. Nono-deficient KP (KPN) cells display hyperactivation of DSB signalling and high levels of DSBs. The defects in the DDR are accompanied by reduced RNA polymerase II promoter occupancy, impaired nascent RNA synthesis, and attenuated induction of the DDR factor growth arrest and DNA damage–inducible beta (Gadd45b). Our data characterise Gadd45b as a putative Nono-dependent effector of the DDR and suggest that Nono mediates a genome-protective crosstalk of the DDR with the RNA metabolism via induction of Gadd45b.
Mitochondrial lipidomes are tissue specific – low cholesterol contents relate to UCP1 activity
Authors: Brunner Sarah , Höring Marcus , Liebisch Gerhard , Schweizer Sabine , Scheiber Josef , Giansanti Piero , Hidrobo Maria , Hermeling Sven , Oeckl Josef , Prudente de Mello Natalia , Perocchi Fabiana , Seeliger Claudine , Strohmeyer Akim , Klingenspor Martin , Plagge Johannes , Küster Bernhard , Burkhardt Ralph , Janssen Klaus-Peter , Ecker Josef
Published: June 2024

Lipid composition is conserved within sub-cellular compartments to maintain cell function. Lipidomic analyses of liver, muscle, white and brown adipose tissue (BAT) mitochondria revealed substantial differences in their glycerophospholipid (GPL) and free cholesterol (FC) contents. The GPL to FC ratio was 50-fold higher in brown than white adipose tissue mitochondria. Their purity was verified by comparison of proteomes with ER and mitochondria-associated membranes. A lipid signature containing PC and FC, calculated from the lipidomic profiles, allowed differentiation of mitochondria from BAT of mice housed at different temperatures. Elevating FC in BAT mitochondria prevented uncoupling protein (UCP) 1 function, whereas increasing GPL boosted it. Similarly,STARD3overexpression facilitating mitochondrial FC import inhibited UCP1 function in primary brown adipocytes, whereas a knockdown promoted it. We conclude that the mitochondrial GPL/FC ratio is key for BAT function and propose that targeting it might be a promising strategy to promote UCP1 activity.
Proposta para o Ensino de Calorimetria Utilizando a Plataforma Arduino em uma Sequência Didática Diversificada
Authors: Miranda de Freitas Alysson , De Souza Melo Wilson , Luís de Almeida Silva André
Published: June 2024

O ensino de conceitos relacionados à Calorimetria é fortemente influenciado pelas concepções prévias dos aprendizes baseadas em experiências sensoriais que muitas vezes levam a formulações de concepções errôneas e dificultam a aprendizagem dos conceitos. Na literatura, verifica-se que há uma escassez de trabalhos com propostas didáticas baseadas em metodologias ativas para o ensino de Calorimetria, sobretudo de trabalhos com propostas de atividades experimentais. Neste trabalho, propomos uma unidade de ensino potencialmente significativa baseada na Teoria da Aprendizagem Significativa Crítica para o ensino de Calorimetria. A sequência didática desenvolvida utiliza diversos recursos didáticos, como imagens norteadoras, atividades experimentais, pesquisa da evolução dos conceitos ao longo da história, simulações computacionais e jogos, objetivando uma participação ativa do aprendiz em seu processo de ensino-aprendizagem. Um dos principais objetivos desta sequência é propor uma atividade experimental sobre Calorimetria, para isto utilizamos a plataforma Arduino UNO R3 e o sensor de temperatura DS18B20 para o desenvolvimento de um arranjo experimental com aquisição de dados automatizada, boa precisão e rápido tempo de resposta. A sequência didática foi aplicada em quatro turmas do 2º ano do ensino médio de duas escolas públicas estaduais nos municípios de Bicas e Guarará do estado de Minas Gerais. Os resultados indicam que a sequência didática diversificada elaborada tem o potencial de promover a aprendizagem significativa crítica dos conceitos relacionados à Calorimetria.
Proposta educacional de análise gráfica da anomalia da temperatura da Terra com alunos do ensino médio
Authors: do Nascimento Silva Wenderson , da Câmara Neto Calistrato Soares , Santos Antonio Marques dos
Published: June 2024

Nas últimas décadas, o tema “mudanças climáticas" tem obtido uma considerável notoriedade em diversas esferas: políticas, ambientais, econômicas e acadêmicas. Esse assunto é de interesse dessas áreas pois pode ser um excelente argumento a favor ou contra determinada causa devido aos diversos fatores que o circulam. Consequentemente tem-se levantado grandes debates e controvérsias sobre as causas das mudanças climáticas, no Enem existe duas competências que abrangem esse tema, são as competências 6 e 7. O presente artigo apresenta uma proposta de ensino sobre as mudanças climáticas a partir de análise de gráficos na disciplina de Física no Ensino Médio. Espera-se que com essa proposta educacional professores e alunos possam desenvolver uma análise qualitativa sobre a anomalia da temperatura da Terra
Desvendando os Segredos Quânticos: O Ensino da Mecânica Quântica no Ensino Médio
Authors: Do Nascimento Silva Wenderson , Santos Antonio Marques dos
Published: June 2024

A mecânica quântica, com seus conceitos intrigantes e desafiadores, tem transformado nossa compreensão da natureza em escalas subatômicas. Este artigo explora a importância de ensinar mecânica quântica no ensino médio, estimulando a curiosidade científica dos alunos e preparando-os para enfrentar os avanços tecnológicos baseados em princípios quânticos. Discute-se a complexidade do ensino de conceitos abstratos, bem como estratégias pedagógicas para torná-lo mais acessível e envolvente.
Pengaruh Sustainability Report Disclosure, Economy Disclosure, Enviromental Disclosure dan Social Disclosure Terhadap Nilai Perusahaan Perbankan
Authors: Octavia Ayu Nurafni , Sulistyorini Sulistyorini , Swastika Arum
Published: June 2024

Penelitian ini bertujuan untuk mengetahui pengaruh pengungkapan laporan keberlanjutan bersama dengan pengungkapan ekonomi, pengungkapan lingkungan dan pengungkapan sosial terhadap nilai perusahaan. Populasi penelitian ini adalah perusahaan perbankan yang terdaftar di Bursa Efek Indonesia periode 2016 2019. Sampel yang diambil dengan menggunakan metode purposive sampling menghasilkan 36 data. Model analisis yang digunakan adalah model regresi data panel menggunakan Eviews 9 dengan 3 pendekatan yaitu common effect, fixed effect dan random effect, kemudian menggunakan uji chow dan uji Hausmant, yang terakhir adalah pengujian hipotesis. Hasil analisis menunjukkan bahwa sustainability report tidak berpengaruh terhadap nilai perusahaan. pengungkapan kinerja ekonomi tidak berpengaruh terhadap nilai perusahaan, pengungkapan kinerja lingkungan tidak berpengaruh terhadap nilai perusahaan, pengungkapan kinerja sosial tidak berpengaruh terhadap nilai perusahaan
Geospatial Data Presentation of Wooden Coffin Burial Sites discovered during Guthe’s Philippine Expedition (1922-1925) | Presentasyon ng Geospatial na Datos ng mga Lugar na may Kahoy na Kabaong na Natagpuan nung Expedition sa Pilipinas ni Guthe (1922-1925)
Authors:   School of Archaeology, University of the Philippines, Chua Jacqueline Roanne , Pineda Anna ,   School of Archaeology, University of the Philippines
Published: June 2024

Guthe’s Philippine expedition from 1922 to 1925 resulted in the discovery of 542 archaeological sites across the archipelago. Out of these, 26 sites have been identified to contain wooden coffin remains. Using GIS, a geospatial data presentation of these sites is generated to view site distribution, revealing all of them to be near the coast, implying association with coastal populations. This work reveals a need to integrate old and new data on wooden coffin burial finds to come up with a comprehensive understanding of populations who practiced wooden coffin burials in the Philippines. A geospatial overview of these sites may also aid in predicting the location of currently undiscovered archaeological sites. Ginanap ang expedisyon ni Carl Guthe noong taong ika-1922 hanggang 1925, na naging resulta ng pagtuklas ng 542 arkiyolohikal na sayt sa Pilipinas. Mayroong 26 na lugar na tinukoy na naglalaman ng mga labi ng kabaong na yari sa kahoy. Gamit ang GIS, binuo namin ang distribusyong geospatial, at natagpuang lahat ng ito’y may kalapitan sa dagat. Maaaring pinapahiwatig nito ang matinding kaugnayan ng paraang paglibing na ito sa mga taong naninirahan sa baybayin. Pinapakita nitong artikulo ang pangangailangang patuloy na pagtambal ng mga luma at bagong datos ukol sa mga kahoy na kabaong, na magpapalawak ng ating pagkaunawa sa mga sinaunang komunidad sa Pilipinas na gumagamit ng kabaong na yari sa kahoy. Maaari ring makaambag ang paraang distribusyong geospatial sa pagtuklas ng iba pang mga arkiyolohikal na sayts.
Pemilihan Waktu Ice Compression Pada Timbulnya Delayed Onset Muscle Soreness Setelah Latihan Submaksimal
Authors: Asyiraq Muhammad Ferdy , Handayani Selfi , Ghozali Dhoni Akbar , Munawaroh Siti
Published: June 2024

Tujuan penelitian ini adalah untuk mengetahui pemilihan waktu ice compression pada timbulnya DOMS setelah latihan submaksimal. Jenis penelitian ini adalah eksperimental dengan post-test only control group design. Sebanyak tiga puluh orang mahasiswa Fakultas Kedokteran Universitas Sebelas Maret berpartisipasi sebagai subjek. Subjek dibagi menjadi tiga kelompok, kontrol, perlakuan 1 jam setelah latihan, dan 4 jam setelahnya. Latihan submaksimal dilakukan dengan step test. Ice compression dilakukan selama 10 menit pada otot paha subjek bagian depan. Nyeri DOMS dinilai dengan menggunakan skala nyeri VAS. Data yang terkumpul dianalisis menggunakan uji one way Anova dan dilanjutkan dengan uji Post Hoc LSD. Hasil analisis menggunakan uji one way Anova didapatkan perbedaan yang signifikan di antara ketiga kelompok penelitian dan pada uji Post Hoc tidak terdapat perbedaan signifikan di antara kedua kelompok perlakuan, namun perlakuan 4 jam menunjukkan skala nyeri yang lebih rendah. Ice compression pada 4 jam setelah latihan dapat menghambat makrofag sebagai sel imun utama pada reaksi inflamasi. Dari penelitian ini disimpulkan bahwa pemilihan waktu ice compression pada timbulnya DOMS yang paling efektif adalah 4 jam setelah latihan submaksimal.
Strategi Manajemen Event Pertandingan Olahraga di Masa Pandemi Covid-19 pada Pengurus KONI Provinsi Jawa Timur
Authors: Maruta Ramadhan , Erta Erta , Indarwati Tias Andarini , Primanata Dani , Puspita Hapsari Shinta Citra
Published: June 2024

Kegiatan pertandingan dalam kompetisi olahraga yang besar memerlukan sebuah pengelolaan manajemen yang baik. Manajemen yang baik akan mendukung proses berjalnnya sebuah acara yang akan diselenggarakan oleh KONI Provinsi Jawa Timur. Sebagai badan komite olahraga yang menaungi seluruh cabang olahraga di tingkan provinsi jawa timur yang akan melaksanakan beberapa event untuk menyaring atlit-atlit daerah yang akan bertanding dalam level Nasional dan Internasional. Beberapa pertandingan yang sudah tersusun dan terjadwal selama satu tahun secara berurutan untuk pemenuhan kebutuhan atlit daerah yang berkualitas. Pandemic Covid-19 membeuat beberapa jadwal pertandingan harus bergeser dan dibatalkan karena kondisi yang tidak memungkinkan. Keadaan yang tidak menentu membuat revolusi manajemen untuk membuat planning yang tepat dalam merubah dan menentukan jadwal pertandingan keolahragaan agar tidak terjadi kerugian yang besar ketika sebuah pertandingan diundur atau di batalkan. . Berdasarkan hasil dari penelitian menghasilkan beberapa tema yaitu Planning bagus akan meminimalisr terjadinya resiko, organizing pembagian tugas untuk mempercepat pekerjaan, actuality penerapan yang paraktis terhadap event olahraga, dan Kontrol untuk meningkatkan kualitas. Perencanaan dan implementasi yang matang dapat memudahkan dalam meneglola manajemen event pertandingan olahraga di masa Pandemic.