bluuebunny/crossref_metadata_2025 huggingface dataset:
Narodna književnost u nastavi srpskog jezika pre i posle reforme nastavnog programa
Authors: Kostić Ljiljana , Purić Daliborka
Published: January 2025

Imajući u vidu vaspitnoobrazovne mogućnosti narodne književnosti, interesovalo nas je da li je izmena nastavnog programa početne nastave srpskog jezika rezultirala promenama u zastupljenosti ovog vida književnosti kao sadržaja nastave. U širem smislu, autori su sagledavali mogućnosti programske reforme za stvaranje podsticajnog razvojnog okruženja usmerenog na učenika, utemeljenog na već uspostavljenim tradicionalnim kulturnim vrednostima, ali i otvorenog za savremena društvena kretanja u kojima će stasavati nove generacije. U fokusu istraživačkih zadataka bilo je poređenje zastupljenosti narodne književnosti kao obaveznog i izbornog sadržaja nastave, pre i posle programskih reformi. Uzorak istraživanja predstavljao je sadržaj nastavnog programa, reformisanog programa nastave i učenja i četrdeset čitanki. Analiza sadržaja pokazuje delimično izmenjen odnos kreatora reformisanog programa i autora udžbenika prema narodnoj književnosti u funkciji cilja i ishoda nastave srpskog jezika, što implicira usložnjavanje zahteva postavljenih pred učitelja, u smislu afirmisanja pojedinih nastavnih sadržaja u skladu sa njihovim vaspitnoobrazovnim potencijalom.
Distopija i antiutopija: žanrovska struktura u romanu Dan kada sam ubrala cvijet
Authors: Giacometti Kristina
Published: January 2025

Jasminka Tihi-Stepanić je hrvatska autorica posvećena pisanju dječje i adolescentske književnosti, a u ovome radu se interpretira njen najnoviji adolescentski roman, Dan kada sam ubrala cvijet (2023). Budući da je riječ o romanu smještenome u svijet budućnosti u kojemu je sve propisano i određeno, u radu se polazilo od definiranja pojmova utopije, distopije i antiutopije kako bi se rasvijetlila terminološka konfuzija. Služeći se dosadašnjim teorijskim spoznajama o problematici žanra, istražuje se formalna, tematska i retorička dimenzija žanra te se pokazuje kako njihova međusobna povezanost u predmetnome romanu oblikuje distopijski žanr. Izdvajanjem i analiziranjem tipičnih odrednica distopijskih romana, naglašava se razlika između antiutopije i distopije pri čemu se roman Dan kada sam ubrala cvijet klasificira u klasičnu distopiju.
Dynamics and Seasonal Fluctuations of Soybean Prices in Domestic and International Markets
Authors: Jadeja R.M. , Thakar K.P. , Marviya P.B. , Soumya C.
Published: January 2025

Background: Soybean, being one of the most widely cultivated crops globally, plays a significant role in global agriculture and food production. However, soybean prices have experienced significant fluctuations over the past few years, causing imbalances in resource allocation and generating demand and supply gaps. Thus, analyzing past price trends is crucial to understand the current scenario and formulate appropriate strategies to improve the marketing system. Methods: This study examines the trends and seasonal variations in soybean prices in local, national and international markets using compound growth rate, trend and seasonality analysis. Monthly and yearly time series data of soybean prices in selected markets were collected from July 2006 to June 2021. The finding revealed a continuous rise in soybean prices in India over the 15 years. Result: The results revealed that the rise in soybean price during this period was due to inflation and farmers were not benefited. Furthermore, the study identified seasonal variation in soybean prices, with peak prices observed during may in most markets, when the crop comes to harvest. The study findings can be useful for policymakers and farmers to understand the trends and seasonal patterns in soybean prices.
La sangre más bella
Authors: Pita Dueñas César
Published: January 2025

...que ha podido verse alguna vez en una pantalla de cine es, sin duda, la italiana. Prueba de ello son los innumerables aportes que desde el giallo o el cine de terror han brindado los grandes autores de esa parte de Europa.
El terror es actual
Authors: Pita Dueñas César
Published: January 2025

Terence Fisher cumple 120 años y en CineScrúpulos hemos querido hacerle un homenaje. Por ello, revisamos una filmografía que revitalizó el género de terror al traer de vuelta a los monstruos clásicos que en la década de 1930 popularizó Universal, pero en un entorno no sujeto a códigos moralistas que aprovechó al máximo la estética a color y la incorporación de ciertos apuntes que incidieron en el apartado de lo sensual.
Cartoon Chaplin: el legado de Charlot a la filosofía Pixar
Authors: Chávez Sabrina , Escalante Alexandra , Gonzales Favio , Malaver Eduardo , Zaldívar Atenas
Published: January 2025

A lo largo de la historia del cine han surgido una serie de exponentes quienes, debido a sus obras, han servido de referencia para los trabajos de nuevos autores cinematográficos. Dentro de este despliegue es posible reconocer el nombre del gran Charles Chaplin, quien junto con su trascendental personaje Charlot ha dejado un legado que seguirá vigente a través de los años, sin importar el paso del tiempo. Si bien la lista de personas que han sido influenciadas por el trabajo de Chaplin es interminable, es necesario destacar el caso de Pixar, productora que desde sus inicios ha hecho grandes homenajes a la larga filmografía del gran icono del cine mudo.
Dossier: Alfred Hitchcock (1899-1980)
Authors: Pita César , Martínez Juan Carlos
Published: January 2025

¿Es necesario a estas alturas dar cuenta de quién es Alfred Hitchcock? Un pequeño resumen: es el maestro del suspenso, el inventor de las triquiñuelas narrativas que trasladan al espectador hacia el lado equivocado (bendito macguffin), el arquitecto visual que cuenta con imágenes sin recurrir a los diálogos explicativos, el bromista que hizo televisión en una época en la que el cine temblaba ante la pequeña pantalla y el estratega que burló la censura cuantas veces pudo. También le gustaban las rubias.
Confesión de parte
Authors: Pita César
Published: January 2025

Los jóvenes de ahora quieren que su abuelo sea Stan Lee, el viejo más chévere del cine moderno. Yo no. A mí me hubiera gustadotener un abuelo como George A. Romero, quien partió a mediados del año pasado a los 77 años.
Kompleksitas Struktur Kalimat Bahasa Indonesia Siswa Sekolah Dasar Inklusi
Authors: Pancarrani Berlian , Mukhlas Moh.
Published: January 2025

This study aims to describe the complexity of basic and transformation sentence structure. This research uses  qualitative approach and cross sectional design. The data in the research are Indonesian sentences from students’ essay of inclusion school students. The data source for this research is essays that written by students of grade 4, 5, and 6 Immersion Elementary School Ponorogo. The results of this study shows (1) normal students and ABK (children with special need) have mastered the simplest sentence structure, namely S-P and made it more complex by adding elements after P, in the form of O, Pel, Ket, or a combination of the three, and (2) normal students of grade 4, 5, and 6 were able to compose single, embedded, density transformation sentences and ABK students composed only a small number of dense transformation sentences.
Analisis Multimodal pada Sampul Majalah Tempo Pilpres 2024: Kajian Semiotika Sosial
Authors: Nuzulia Isma Farikha Latifatun
Published: January 2025

This research aims to analyze the newspaper coverage of the presidential election 2024 because this issue was a controversial phenomenon and has many perspectives for the community. The method used was descriptive qualitative since it describes a social phenomenon with the verb and visual meaning. The source was obtained from the Tempo website with politically based, namely https://majalah.tempo.co , and the data was an optical element and languages such as phrases and sentences. After analysis, it was found that all data is based on the idea of the 2024 presidential election in a narrative representational form because the visual maker presents a story from the elements that appear. In the interactive meaning, the visual maker uses statements and interrogative sentences to interact with the reader and employs an eye-high view visual form parallel to the reader's eye line. Then the textual meaning and composition are presented in the form of all verbs as a linguistic expression for the visual maker and certain elements that want to highlight, such as the color red, President Jokowi, billboards on the street, and ministers.
Die Multi-Informanten-Perspektive auf dem Prüfstand : Fremdeinschätzungen zu sozial-emotionalen Kompetenzen von Kindergartenkindern im Vergleich
Authors:   , Schönmoser Carina Franziska
Published: January 2025

Sozial-emotionale Kompetenzen sind besonders relevant für den späteren Erfolg in Schule und Beruf. Da Kinder mit unterschiedlich ausgeprägten kognitiven Kompetenzen in die Grundschule starten, ist es nötig, mögliche Mechanismen sozialer Ungleichheit schon im Kindergarten und im Zusammenhang mit sozial-emotionalen Kompetenzen zu untersuchen. Doch die Erfassung sozial-emotionaler Kompetenzen birgt viele Herausforderungen, welche in der Konsequenz Fragen für die Weiterverwendung der erfassten Konstrukte in wissenschaftlichen Sekundäranalysen aufwirft. In der hier dargestellten Forschung wurden daher die möglicherweise verzerrten Eltern- und ErzieherInnen-Einschätzungen sozial-emotionaler Kompetenzen von Kindergartenkindern und der Zusammenhang zu ihren späteren kognitiven Kompetenzen betrachtet, um Empfehlungen für Forschung und Praxis ableiten zu können.
Regulating the solvation environment of hybrid electrolytes towards high-temperature zinc-ion storage
Authors: Xie Yulin , Dou Qingyun , Li Guosheng , Chen Yuecong , Yan Xingbin
Published: January 2025

Zinc-ion batteries (ZIBs) are being explored as a potential alternative to lithium-ion batteries owing to the growing demand for safer, more sustainable, cost-effective energy storage technologies. In such systems, electrolytes, as one of the key components, have a decisive impact on their electrochemical performance. However, Zn anodes in traditional aqueous electrolytes exhibit drawbacks such as severe hydrogen evolution reactions, Zn corrosion and passivation especially at high temperatures, leading to poor cycling performance of ZIBs. Herein, we designed and evaluated a series of hybrid electrolytes consisting of zinc tetrafluoroborate hydrate [Zn(BF4)2·xH2O] as the solute and various organic solvents [tetraglyme (G4), propylene carbonate, and dimethylformamide] for high-temperature ZIBs. Comparative analysis revealed that G4-based hybrid electrolytes exhibit a unique Zn2+ solvation structure primarily surrounded by organic solvent rather than H2O, which substantially reduces H2O-related side reactions and thus promotes more reversible Zn deposition than propylene carbonate-based and dimethylformamide-based hybrid electrolytes. The superiority of G4-based hybrid electrolyte is further confirmed by long stable cycling life of the corresponding Zn||Zn symmetric cell (> 350 h) and Zn-ion capacitor full cell (over 1,400 cycles with 90.7% capacity retention) at 60 °C.
Analisis Rasch Model pada Instrumen Pre-Test Mahasiswa Program Studi Profesi Dokter Bagian Ilmu Kedokteran Forensik dan Medikolegal Fakultas Kedokteran Universitas Padjadjaran Bandung
Authors: Sayusman Chevi
Published: January 2025

Pre-Test mahasiswa Program Studi Profesi Dokter (PSPD) di bagian Ilmu Kedokteran Forensik dan Medikolegal (IKFM) merupakan instrumen test pada tahap awal pendidikan. Pre-Test tersebut dikembangkan oleh staf pengajar bagian IKFM sebagai instrumen untuk mengetahui kemampuan mahasiswa dan  mengenalkan hal-hal yang perlu diketahui pada proses pendidikan. Rasch model digunakan untuk menganalisis Pre-Test tersebut. Penggunaan Rasch model ditujukan untuk menguji validitas dan reliabilitas instrument Pre-Test. Metodologi yang digunakan  adalah kuantitatif. Pre-Test menggunakan pilihan berganda terediri dari 3 pilihan. Sampel hasil Pre-Test terdiri dari 291 sampel. Hasil penelitian menunjukan Person measure = 0,37; Nilai Alpha Cronbach (mengukur reliabilitas) 0,74, menunjukan bagus; Person reliability 0.71, menunjukan cukup; Item reliability 0,99, menunjukan istimewa; Untuk person nilai INFIT MNSQ 0,99 dan OUTFIT MNSQ  1,06, menunjukan kualitas yang baik; Nilai separation person H= [(4x1,57) +1]/3 =  2,43, bermakna terdapat dua kelompok responden. Nilai separation item H= [(4xseparation) +1]/3=[(4x8.6) +1]/3= 11.8, bermakna terdapat 12 kelompok item. Berdasarkan Outfit MNSQ terdapat 1aitem yang misfit, yaitu n24. Instrumen Pre-test dapat disimpulkan baik dan dapat digunakan dengan modifikasi atau mengganti 1 aitem yang misfit.
studi kasus KEKERASAN TAJAM DENGAN CIDERA VASKULER PADA TIGA KASUS PEMBUNUHAN
Authors: Yanuarti Ainun Fahmi , Suciningtyas Martiana
Published: January 2025

PENDAHULUAN
Pembunuhan dengan kekerasan tajam merupakan salah satu penyebab kematian utama di beberapa negara. Kekerasan tajam dapat disertai dengan cidera vaskuler pada pembuluh darah yang tanpa adanya pertolongan segera seringkali berakhir pada kematian. Berikut akan didiskusikan tiga kasus pembunuhan dengan kekerasan tajam yang melibatkan cidera vaskuler dan berakhir kematian.
MATERIAL DAN METODE
                Materi diskusi berupa tiga kasus pembunuhan dengan kekerasan tajam yang melibatkan cidera vaskuler di Yogyakarta. Kasus pertama adalah laki-laki dengan luka tusuk pada paha kiri, pada pemeriksaan dalam didapatkan srteri dan vena femoralis dalam keadaan terpotong. Kasus kedua adalah seorang laki-laki dengan dua luka bacok pada paha kanan, satu luka pada tungkai bawah kanan dan satu luka bacok pada tungkai bawah kiri. Dari uji bilas pembuluh nadi kanan didapatkan kebocoran pada pembuluh darah tungkai bawah kanan sisi belakang. Kasus ketiga merupakan seorang perempuan dengan beberapa luk tusuk: empat pada leher, satu pada dada kiri, satu pada punggung kiri dan satu pada lengan atas kanan serta satu luka iris pada siku kiri. Dari pemeriksaan dalam terlihat bahwa arteri carotis interna terpotong.
KESIMPULAN
                Ketiga kasus memiliki pola luka seperti ciri-ciri luka dalam pembunuhan yakni luka bisa terjadi di sembarang area tubuh, dijumpai luka tangkis dan kerusakan pakaian. Cidera vaskular yang terlibat pada ketiga kasus menghasilkan mekanisme kematian yang sama, yakni perdarahan masif.
Child Sexual Abuse (CSA) Using Hypnosis
Authors: Ika meilia Putri Dianita , Susanto Mardi
Published: January 2025

Child sexual abuse (CSA) is a global problem and a serious public health issue. Perpetrators often resort to threats and force to incapacitate their victims, including using hypnosis. The use of hypnosis increases the level of difficulty of clinical forensic examination by presenting a diagnostic issue and complicating the formulation of forensic medical expert opinions. This evidence-based case report (EBCR) aims at assessing the available evidence concerning the forensic examination and diagnosis of hypnosis-facilitated CSA. A comprehensive computer-based literature search was performed using several keywords related to the clinical question. The search yielded seven relevant articles. The articles were appraised using general critical appraisal questions from the Centre for Evidence-Based Medicine, University of Oxford. All articles suggest that there might be a place for hypnosis in a criminal investigation (‘forensic hypnosis’). The evidence on the correct application of forensic hypnosis and its benefits are, however, still inconclusive and conflicting. In cases of suspected sexual assault using hypnosis, forensic hypnosis could potentially help memory recall of the victim and aid forward-thinking in drawing a clear and unambiguous conclusion for the forensic medical expert opinion.
Photographic Identification of Tooth Prints After High Temperature Exposure
Authors: Khaerunnisa Rahmadaniah , Oscandar Fahmi , Syukriani Yoni
Published: January 2025

Tooth prints is a very potential tool in forensic identification as the enamel rod patterns on tooth surface is individually unique. This study was aimed to detect changes of tooth prints after teeth were exposed with high temperatures. Forty-five extracted teeth were divided into 5 groups, then exposed to various high temperatures for 15 minutes in a furnace. To ensure practical application, a highly reproducible digital photographic method to detect tooth prints was developed. Before and after the heating process, tooth prints were photographed. The image data was analysed using an open-source biometric software, and the number of matching points of each tooth was compared before and after treatment. Results showed the decreasing number of match points of tooth prints in accord with the increasing of temperature exposure (P < 0.05). The number of tooth print matching points can be confidently observed at temperatures 600°C or lower. The consistence of matching points shows the prospect of tooth print analysis to become a reliable identification method. This digital photography technique offers a straightforward method for routine dental recording in daily practice by dentists and identification by forensic odontologists. It opens further direction for standardization of pattern analysis, database development, and daily protocols.
Keywords:
dental photography; forensic identification; high temperature; tooth prints
CARBON MONOXIDE POISONING: LITERATURE REVIEW
Authors: Levina Gina
Published: January 2025

Carbon monoxide (CO) is known as a colorless, odorless, tasteless, and non irritating gas. CO produced from burning gasoline, wood, charcoal, propane, or other fuels. CO competes with oxygen to bind with Hb, forming COHb and leads to shifting the oxyhemoglobin dissociation curve to the left, reducing oxygen-carrying capacity, and oxygen release into the peripheral tissue. Tissue hypoxia due to CO induces vascular permeability and increased interstitial fluid accumulation with decreased circulating blood volume affecting multiple organs. Three clinical sequences consisted of symptoms consistent with CO poisoning, recent history of CO exposure, and elevated HbCO levels should be present in diagnosing CO poisoning. The current mainstay of CO poisoning treatment is high flow, normobaric (NBO) oxygen therapy administered as soon as possible.
SEXUAL VIOLENCE CASE PROFILE AT THE REGIONAL RSUD DR. RM. DJOELHAM BINJAI IN 2022
Authors: Julanda Baari Putra , Lubis Adriansyah , Marbun Doaris , Ismurizal Ismurizal , Arviandi Rizki
Published: January 2025

Introduction
Sexual crimes are crimes of morality in which every act committed by a person against another person results in sexual satisfaction for himself and disturbs the honor of others. In Indonesia, women and minors are often the victims of sexual crimes.
Method
This research is descriptive research with a cross-sectional approach. The population in this study was all data examined at the Forensic and Medicolegal Installation at Dr. RSUD. RM. Djoelham Binjai in 2022. The research sample was obtained from all data examined at the Forensic and Medicolegal Installation at RSUD Dr. RM. Djoelham Binjai on Sexual Violence Cases in Binjai City in 2022 using the total sampling method. Data collection was carried out using secondary data.
Results
Sexual violence cases examined in Dr. Hospital RM. Djoelham Binjai in 2022 were 46 victims. The highest number of cases of sexual violence based on age was in the early teens age group 12 - 16 years with 28 victims with a percentage of 60.8%. The number of women who experienced cases of sexual violence based on the relationship between the victim and the perpetrator, the highest was 42 victims who were people the victim knew with a percentage of 91.3%. The number of sexual violence cases based on the type of sexual violence was highest in cases of sexual abuse, 36 victims with a percentage of 78.3% and the lowest in rape cases, 10 victims with a percentage of 21.7%.
Authors: Badriyah Farih Nurul , Malasari Putri Nur , Wahyuni Fina Tri
Published: January 2025

Statistika merupakan suatu ilmu matematika yang sangat penting bahkan dianjurkan untuk dapat difahami dalam kehidupan. Oleh sebab itu, siswa harus dapat mengerti konsep yaang digunakan dengan baik. Fokus penelitian ini adalah untuk menganalisis kesalahan yang dilakukan siswa serta mengetahui apakah siswa dapat mengikuti prosedur dengan baik atau tidak yang mungkin disebabkan karena kurangnya latihan dan ketelitian dalam memecahkan persoalan yang diberikan berdasarkan kesalahan kastolan. Metode dalam penelitian ini menerapkan pendekatan deskriptif kualitatif. Siswa di kelas X IPS 2 pada Madrasah Aliyah di Undaan Kudus yang berjumlah 17 siswa merupakan subjek dari penelitian ini dengan menggunakan test tertulis dengan 5 soal cerita berbentuk uraian mengenai materi statistika. Analisis ini menyimpulkan bahwa dalam menyelesaikan permasalahan siswa masih sering melakukan kesalahan karena mereka belum memahami konsep penggunaan rumus, salah dalam menyusun langkah-langkah yang sesuai, dan kurang teliti dalam mengitung.
Authors: Shofiyulloh M. , Munandar Arif , Wardati Khurul
Published: January 2025

ABSTRAK.  Graf prima koprima atas grup hingga merupakan representasi grup hingga pada graf dengan memandang anggota grup sebagai vertek dari graf dan dua vertek berbeda  dan  adjacent jika dan hanya jika order  dan order  adalah bilangan prima atau saling prima. Penelitian ini mengkaji bagaimana karakterisasi graf prima koprima atas grup dihedral. Melalui analisis terhadap pola yang muncul pada graf yang terbentuk, dapat ditemukan sifat sifat dari graf prima koprima atas grup dihedral yang berkaitan dengan karakterisasi graf komplit dan graf Hamilton. Kemudian, penelitian ini diakhiri dengan pembahasan konektivitas vertek pada graf prima koprima atas grup dihedral.
Identifikasi dan Upaya Pemenuhan Kebutuhan Informasi Terkait Pemeliharaan Kesehatan Reproduksi Remaja Melalui Kegiatan Edukasi pada Siswa Sebuah SMP di Kabupaten Cilacap
Authors: Widiartini Catharina , Pribadi Fajar Wahyu , Sutasman Thomas , Kuncoro Prasetyo Tri , Setiawan Agus Budi
Published: January 2025

Meningkatnya permasalahan kesehatan reproduksi remaja akibat dampak buruk pajanan internet selama masa pembelajaran daring perlu mendapat perhatian kita bersama. Hal ini diperburuk oleh tertutupnya jalur komunikasi dengan orang tua akibat pandangan bahwa pembicaraan kesehatan reproduksi merupakan hal tabu. Permasalahan ini pun relevan bagi SMP Pius, Cilacap, Jawa Tengah. Upaya identifikasi kebutuhan pengetahuan mengenai berbagai aspek kesehatan reproduksi bagi para siswa mengawali langkah selanjutnya berupa kegiatan edukasi. Sebanyak 80 siswa kelas 8 dan 65 siswa kelas 9 (total 145 siswa), dengan rerata usia 13,3 tahun mengikuti kegiatan ini. Penyampaian materi terkait aspek biologis, psikologis dan sosial kesehatan reproduksi remaja dilaksanakan secara langsung melalui ceramah, diskusi interaktif, games dan menonton video edukasi, serta secara tertulis melalui modul yang dibagikan. Rerata persentase siswa yang menjawab benar pada pre-test sebesar 74,31 % dan pada post-test sebesar  74,92%. Terdapat peningkatan pengetahuan siswa pasca pelaksanaan kegiatan yang ditunjukkan dengan adanya peningkatan nilai minimal dan maksimal serta modus pada post-test. Tingkat pengetahuan siswa pada 15 sub topik kesehatan reproduksi memadai, sedangkan pada 10 sub topik kesehatan reproduksi kurang kurang memadai. Kegiatan selanjutnya dapat memprioritaskan upaya peningkatan pengetahuan siswa yang kurang memadai pada beberapa aspek tersebut. Kegiatan ini perlu dirutinkan dengan memperluas sasaran melalui peningkatan kapasitas guru sebagai fasilitator dan narasumber dalam diskusi masalah kesehatan reproduksi remaja dengan siswa.
Bersinergi Menurunkan Angka Stunting Kabupaten Banyumas Melalui Pendampingan Keluarga
Authors: Santosa Qodri , Hapsari Ariadne Tiara , Oliviany Windy , Agustina Nenden Nursyamsi , Muntafiah Alfi , Windiya Fajar , Syamsiedi Naluri Widyaningsih , Susilarto Aris Dwi
Published: January 2025

Keluarga sebagai lingkungan utama tumbuh kembang anak, memiliki peran sentral dalam memberikan dukungan dan perawatan optimal bagi anak. Dalam pelaksanaannya, keluarga seringkali menghadapi berbagai permasalahan dan tantangan yang berpotensi mempengaruhi status gizi dan kesehatannya sehingga terjadi stunting. Tujuan kegiatan ini untuk memberikan pendampingan kepada keluarga stunting. Melalui pendampingan langsung, tim pengabdi dapat lebih mendalam memahami tantangan dan kebutuhan keluarga. Metode kegiatan dilakukan dengan pendekatan holistik dan berbasis partisipatif, yang melibatkan interaksi langsung dengan sejumlah 187 keluarga stunting di wilayah Puskesmas Purwokerto Timur I, II dan kembaran I. Pendekatan ini diharapkan dapat menciptakan perubahan positif dan berkelanjutan dalam mengatasi stunting Kegiatan meliputi kunjungan rumah, pemeriksaan fisik, Tes Deteksi Dini (TDD), Kuesioner Pra Skrining Perkembangan (KPSP), dan pemeriksaan Denver II. Kegiatan diakhiri dengan pemberian rekomendasi untuk mengarahkan intervensi yang sesuai dengan kebutuhan masing-masing anak. Melalui kegiatan ini, keluarga diharapkan mendapatkan dukungan yang efektif dalam meningkatkan status gizi dan perkembangan anaknya.
Peran Serta Akademisi dalam Aktivasi Yayasan Thalassemia Indonesia Cabang Banyumas
Authors: Rujito Lantip , Siswandari Wahyu , Lestari Diyah Woro Dwi , Faiza Dinar , Aminah Siti , Purwoko Ari , Suprihatin Suprihatin
Published: January 2025

Thalassemia telah menjadi masalah kesehatan yang mendesak di Indonesia karena tingginya prevalensi pembawa dan individu yang terkena. Keberagaman kelompok etnis di nusantara berkontribusi pada distribusi jenis thalassemia yang bervariasi, dengan beta-thalassemia menjadi yang paling umum. Data epidemiologi menggarisbawahi kebutuhan mendesak untuk strategi komprehensif untuk memerangi thalassemia dan meningkatkan kualitas hidup individu yang terkena. Gerakan thalassemia di Indonesia diprakarsai oleh Yayasan Thalassemia Indonesia (YTI). YTI telah muncul sebagai kekuatan pendorong di balik peningkatan kesadaran, mengadvokasi kebijakan perawatan kesehatan yang lebih baik, dan mendorong jaringan dukungan untuk pasien dan keluarga mereka. Kegiatan yayasan mencakup berbagai bidang, termasuk kampanye publik, program pendidikan, dan inisiatif penelitian. Upaya kolaboratif antara yayasan dan akademisi telah mendorong pendekatan sinergis, menggabungkan keahlian ilmiah dengan advokasi akar rumput dan keterlibatan masyarakat. Partisipasi akademisi memainkan peran penting dalam membentuk kegiatan yayasan, mulai dari penelitian dan peningkatan kapasitas hingga konseling dan skrining genetik. Kekuatan kemitraan interdisipliner dalam mengatasi tantangan kesehatan yang kompleks diharapkan dapat meningkatkan kehidupan individu yang terkena thalassemia.
Pemeriksaan Glukosa Darah Dan Kolesterol Serta Penyuluhan Kesehatan Tentang Hiperkolesteronemia dan Komplikasi Diabetes Mellitus Pada Warga Dengan Overweight Dan Obesitas Di Desa Kalibagor, Kecamatan Kalibagor, Kabupaten Banyumas
Authors: Wahyudin Wahyudin , Arjadi Fitranto , Setyanto Muhamad Rifqi , Pauzi Rizqi Yanuar , Riyanto Slamet , Saad Nursan
Published: January 2025

Overweight dan obesitas telah menjadi masalah kesehatan global yang serius, termasuk di Indonesia. Kondisi ini tidak hanya mempengaruhi penampilan fisik, tetapi juga meningkatkan risiko berbagai penyakit kronis, seperti diabetes mellitus dan penyakit jantung. Pemeriksaan glukosa darah dan kolesterol secara berkala merupakan langkah penting dalam deteksi dini diabetes mellitus dan hiperkolesteronemia. Diabetes mellitus, suatu kondisi di mana tubuh tidak dapat memproduksi atau menggunakan insulin dengan baik, dapat menyebabkan berbagai komplikasi serius jika tidak ditangani dengan tepat, seperti kerusakan ginjal, saraf, dan penglihatan. Pengabdian masyarakat yang dilakukan yaitu pemeriksaan GDS dan kolesterol total kemudian dilanjutkan dengan penyuluhan kesehatan tentang hiperkolesteronemia dan komplikasi diabetes mellitus. Hasil pemeriksaan diperoleh sebagian besar warga yang hadir mengalami overweight dan obesitas sebanyak 70%, dan sisanya mempunyai berat badan yang normal, yang mengalami diabetes sebanyak 12%.  Peningkatan kesadaran masyarakat tentang pentingnya menjaga berat badan dalam rentang normal, bersama dengan pola hidup sehat, dapat membantu menurunkan prevalensi penyakit metabolik di masa depan.
Edukasi Pencegahan Hiperkolesterolemia Dan Komplikasinya Pada Peserta Program Pengelolaan Penyakit Kronis (Prolanis) Di Puskesmas Purwokerto Timur
Authors: Harini Ika Murti , Gumilas Nur Signa Aini , Nafiisah Nafiisah , Silva Ghea De , Tamad Fatiha Sri Utami
Published: January 2025

Hiperkolesterolemia meningkatkan risiko penyakit kardiovaskular dan penyakit lain. Pemerintah mengelola penyakit ini, khususnya diabetes melitus dan hipertensi, melalui Program Pengelolaan Penyakit Kronis (Prolanis) termasuk di Puskesmas Purwokerto Timur 1. Data di Puskesmas Purwokerto Timur menunjukkan hanya 53,89% dari 167 anggota Prolanis yang rutin mengikuti kegiatan Prolanis. Hal ini kemungkinan disebabkan oleh kurangnya pengetahuan tentang penyakitnya. Diagnosis, pemilihan, dan pemberian obat yang tepat oleh tenaga kesehatan tidak cukup menjamin keberhasilan terapi jika tidak didukung dengan pemahaman yang baik dari pasien. Oleh karena itu, diadakan kegiatan edukasi tentang hiperkolesterolemia dan faktor risikonya untuk mencegah komplikasi lebih lanjut pada peserta Prolanis di Puskesmas Purwokerto Timur 1. Kegiatan ini memberikan manfaat tambahan berupa peningkatan pengetahuan peserta tentang pentingnya mengenali faktor risiko hiperkolesterolemia untuk mencegah komplikasi.
KORELASI USIA DAN JENIS KELAMIN DENGAN GRADING LIMFOMA NON HODGKIN SEL B DI RSUD PROF. DR. MARGONO SOEKARJO PURWOKERTO
Authors: Pangestu Thomas Adi , Sulistyo Hidayat , Djatmiko Wahyu , Novrial Dody , Mardhihusodo Hajid Rahmadianto
Published: January 2025

Latar Belakang: Limfoma non-Hodgkin (LNH) dibedakan menjadi dua kelompok utama, yaitu limfoma sel B dan limfoma sel T/NK. Tipe LNH paling banyak di dunia adalah LNH sel B. Salah satu cara mengelompokkan LNH sel B yaitu dengan menggunakan pemeriksaan histopatologi untuk membedakan grading menjadi low grade dan high grade. Tingkat kejadian LNH sel B meningkat bertahap berdasarkan usia dan lebih banyak terjadi pada laki-laki. Penelitian ini bertujuan untuk mengetahui apakah terdapat hubungan antara usia dan jenis kelamin dengan grading LNH sel B. Metode: Penelitian ini merupakan penelitian analitik observasional dengan pendekatan cross sectional yang dilakukan pada pasien limfoma non-Hodgkin sel B di RSUD Prof. Dr. Margono Soekarjo Purwokerto pada tahun 2019-2021. Analisis data menggunakan uji Chi-square. Hasil: Total sampel yang didapatkan adalah 75 pasien LNH sel B. Sebanyak 47 (62,7%) pasien berusia <60 tahun dan 28 (37,3%) pasien berusia ⩾60 tahun. Pasien laki-laki berjumlah 40 (53,3%) pasien, lebih banyak daripada perempuan yang berjumlah 35%. Hasil analisis menunjukkan bahwa tidak terdapat hubungan antara usia dengan grading (p=0,617), serta jenis kelamin dengan grading (p=0,366). Kesimpulan: Tidak terdapat hubungan antara usia dengan grading LNH sel B. Tidak terdapat hubungan antara jenis kelamin dengan grading LNH sel B.
Factors Influencing the Outcomes of Liver Resection at Benjamini Mkapa Hospital Dodoma, Tanzania: A Retrospective Cross-Sectional Study
Authors: Mvandal Samson Peter
Published: January 2025

Globally, liver resection outcomes have improved significantly due to advancements in surgical techniques. However, in developing countries like Tanzania, it remains a relatively new procedure with limited experience and higher associated risks. This study aims to assess the factors influencing outcomes of liver resection at Benjamin Mkapa Hospital among patients who underwent liver resection. A cross-sectional retrospective study design included all patients who underwent liver resection at Benjamin Mkapa Hospital during the study period. Data on socio-demographic and clinical characteristics, surgical outcomes, and influencing factors were collected from patient files and the Jeeva system. Statistical analysis was performed using SPSS software v25. A total of 18 patients were included, with a predominance of female patients (77.8%) and an evenly distributed residence pattern. Postoperative complications were observed in 38.9% of the cases, with liver-related complications being the most common (27.8%). Renal and respiratory complications each occurred in 16.7% of patients, and 16.8% of the patients (3 cases) died postoperatively. The study highlights the complexity and risks associated with liver resection at Benjamin Mkapa Hospital, with a notable rate of postoperative complications. Age and biopsy findings were key factors influencing outcomes, including complications, hospital stay, and mortality. These findings emphasize the importance of preoperative evaluation and patient selection to improve surgical outcomes.
Zephycandidine A and Synthetic Analogues – Synthesis and Evaluation of Biological Activity
Authors: Klaßmüller Thomas , Lengauer Florian , Blenninger Julia , Geisslinger Franz , Bartel Karin , Bracher Franz
Published: January 2025

A convenient total synthesis of the cytotoxic imidazo[1,2-f]phenanthridine-type Amaryllidaceae alkaloid zephycandidine A (3) was developed, which further allowed to perform modifications of substituents at the benzenoid ring A and the imidazole ring D. The biological activities of all synthesized compounds were evaluated, whereby reported activities of the parent alkaloid were poorly reproducible, while the closely related analogue THK-121 (11) showed a strong inhibitory effect on proliferation of leukemia cells. Additionally, our novel analogue significantly induced cell death via the intrinsic apoptosis pathway, evident by loss of mitochondrial membrane potential, increased mitochondrial oxidative stress and disrupted mitochondrial structure, in the same cells. At the same time, healthy cells were hardly affected by the treatment with THK-121 (11), indicating a potential therapeutic margin.
Green Exposure, Depression, and Inflammatory Biomarkers: A Prospective Study
Authors: Pavarino Gianna , Brasso Claudio , Boido Marina , Carluccio Anna , Cirulli Francesca , Mengozzi Giulio , Schellino Roberta , Vercelli Alessandro , Rocca Paola
Published: January 2025

Major depressive disorder and bipolar disorders are prevalent mental health conditions that significantly impact quality of life and life expectancy. These mood disorders involve major depressive episodes (MDE), which pose a substantial burden for patients and their families. While psychopharmacological therapies are a first-line treatment for MDE, the response is often incomplete. New approaches focused on the human-nature relationship may potentially complement antidepressant treatments, thus reducing psychopharmacological needs. This study aims to evaluate whether green exposure affects depressive symptoms and inflammatory biomarker levels in patients with MDE. This prospective study examined the association between exposure to green environments such as woods, forests, large parks, and gardens for at least 45 minutes twice a week, depressive symptoms, and inflammatory biomarkers in 31 patients with an ongoing MDE. The findings suggest that exposure to greenness, together with the modification of antidepressant therapy, is associated with improved depressive symptoms, lower levels of inflammatory biomarker interleukin-6, and higher concentrations of adiponectin after six weeks of treatment. These results suggest that exposure to green environments may have a favorable impact both on mental health and on inflammatory processes, and thus represent a complementary therapeutic strategy. Such information could be relevant to clinicians and urban planners.
3D Visualization of Articulated Mechanisms: Coupling Their Dynamic and Virtual Models on Example of Driving of the Omnidirectional Mobile Robot
Authors: Damic Vjekoslav , Cohodar Husic Maida
Published: January 2025

This paper proposes novel approach to 3D virtual modeling of articulated mechanisms. It follows widespread use of XML for various applications and defines a version of XML specially designed for description of 3D geometric models of articulated bodies. It was shown how the 3D geometric model of a mechanism can be gradually developed using suitable defined elements and stored in corresponding XML file. The developed XML model is processed and using powerful VTK (Visualization Toolkit) library the corresponding virtual model is built and shown on the computer screen. To drive the virtual model the dynamical model of the mechanism is developed using Bond Graph modelling techniques. The models, 3D virtual geometric and dynamic, are created using the corresponding software packages: BonSim3D Visual and BondSim. The models are interconnected by a two-way named pipe. During the simulation of dynamical model, the parameters necessary to drive the virtual model (e.g., the joint displacements) are collected and sent to the virtual model over the pipe. When the virtual model receives a package the computer screen is updated showing the new state of the mechanism. The approach was demonstrated on example of a holonomic omnidirectional mobile robot.
The Effects of Echinacea (EP107TM) on Anxiety: A Comparison of Anxiety Measures in a Randomized, Double Blind, Placebo-Controlled Study
Authors: Haller Jozsef , Gábor Faludi , Gábor Kovacs , György Purebl , Zoltán Füzesi , Tamás Freund F.
Published: January 2025

Background/Objectives. Beyond its well-known effects on upper respiratory tract infections, it was shown repeatedly that Echinacea extracts with unique alkamide profiles (EP107TM) decrease anxiety in both animals and humans. In a recent study, however, an extract identical to those used earlier failed to decrease anxiety more than placebo, although it enhanced wellbeing and induced anti-depressant-like effects as compared to placebo. The psychometric instrument used in this study, the Clinically Useful Anxiety Outcome Scale, focuses on physical symptoms of anxiety, whereas the State-Trait Anxiety Inventory that was employed earlier focuses on psychic symptoms. Methods. To study the influence of the anxiety measure on the detectability of anxiolytic effects, here we studied the effects of Echinacea EP107TM by means of the Hospital Anxiety and Depression Scale – anxiety subscale (HADS-A), which focuses on psychic symptoms, and the Hamilton Anxiety Rating Scale (HAM-A), most items of which investigate physical symptoms. The study was placebo-controlled, double blind and multicenter. Results. The extract significantly alleviated anxiety over the effects seen with placebo when studied with HADS-A. Total scores of HAM-A did not reveal significant treatment effects. However, Echinacea was superior to placebo in three psychic anxiety items of the HAM-A. Conclusions. Taken together, these findings suggest that Echinacea EP107TM efficiently decreases psychic anxiety without affecting somatic anxiety symptoms. This indicates that the preparation may be used in mild forms or incipient phases of anxiety when somatic symptoms are not yet accentuated.
The Influence of the Number of Pistons on the Pressure Pulsations and Vibration of the Axial Piston Pump Housing
Authors: Radosavljević Milan , Stošić Lazar , Mihajlović Slavica R. , Đorđević Nataša G. , Petrović Radovan , Lozanović Šajić Jasmina
Published: January 2025

The number of pistons in axial piston pumps plays a significant role in determining the performance characteristics of the pump. While increasing the number of pistons can improve capacity, stability, and flow, it also requires careful consideration of design complexity and operational efficiency. The optimal number of pistons will depend on the specific requirements of the application and the trade-offs that can be effectively managed. With multiple pistons operating together, the resulting pressure profile is smoother, reducing fluctuations that can affect system performance. This is crucial in applications where stable pressure is necessary, as it can improve the reliability and efficiency of the hydraulic system. Each piston contributes to the total displacement, resulting in an increase in flow rate. However, this must be balanced against the potential for increased internal friction and the complexity that can arise from multiple moving parts. The effect of the number of pistons on vibration and operating balance is another important factor. A well-balanced multi-piston pump can minimize pulsations and vibrations, resulting in smoother operation. This is essential for applications where excessive vibrations can lead to wear or system instability.
Bioprospecting of Bixa orellana L. for the Selection of Characters with Biological Activity
Authors: Guerrero-Lagunes Luz A. , Ruiz-Posadas Lucero M. , Cadena-Iñiguez Jorge , Soto-Hernández Ramon Marcos , Avendano-Arrazate Carlos H. , Aguirre-Medina Juan F. , Soto-Mendoza Celeste , Aguirre-Cadena Juan F.
Published: January 2025

A meta-analysis of 28 sources of information was conducted, considering different variables in Bixa orellana, with the aim of identifying bioprospective variables. Variables were approached, such as the organ of extraction, extraction method, 63 biochemical classes, and 20 for biological activity, and their states were codified. The statistical analysis was developed through a cladistics analysis using the WinClada version1.00.08 84,85 software and the explicative accumulated variance was determined through a descriptive multivariate analysis and multiple correspondence analysis (MCA). The tree obtained showed the genotype Africa 1 as the one closest to the basal state. After Africa 1, 9 clades are derived and the genotypes Colombia3 and Colombia5 were the most evolved. The analyses demonstrated that in B. orellana L., the genotypes from India, Brazil and Yucatán present anticancer activity against the cell lines U251, MCF-7, HeLa, NCI-H460, PC-3, A549 and HT-29, as well as biological activity against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa, related primarily with biochemical compounds such as geranylgeraniol, ellagic acid, and carotenoids (bixin and norbixin), naringenin and alkaloids. The conditions of reproductive isolation of the genotypes mentioned before providing the ideal agroclimatic conditions to produce compounds with biological activity.
Geometric Models of Speciation in Minimally Monophyletic Genera using High-Resolution Phylogenetics
Authors: Zander Richard H.
Published: January 2025

High-resolution phylogenetics using both morphology and molecular data reveals surfactant-like trait buffering of peripatric descendant species that facilitates resilience for supra-specific entities across geologic time. Regular polygons inscribed in circles model balanced areas of survival of various numbers of new species in one genus. This models maximizing peripatric survival of descendant species, with populations partly in allopatric habitats and in sympatric areas. It extends theory advanced with Willis’s Age and Area hypothesis. Hollow curves of the areas bounded between a series of inscribed regular polygons and their containing circles show a ranked progression governed by similar power laws of other phenomena, including Zipf’s law and a universal meta-law in physics. This model matches best the physics meta-law (law of laws) but is only one of several somewhat different curves generated by somewhat different processes. A rule of four can explain why most genera in vascular plants exhibit a hollow curve of optimally one to five species per genus. It implies a constraint on variation that enhances survival, and provides a physics explanation for the monophyletic skeleton of macrogenera. A high-resolution form of ancestor-descendant analysis is compared to traditional phylogenetic analysis as to best modeling of the demonstrable results of evolutionary processes. Arguments are advanced for the preserving of scientific concepts of taxa over cladistic clades.
Transcriptomics, Proteomics and Bioinformatics in Atrial Fibrillation: A Descriptive Review
Authors: Belfiori Martina , Lazzari Lisa , Hezzell Melanie Jane , Angelini Gianni D. , Dong Tim
Published: January 2025

Atrial fibrillation (AF) is the most frequent cardiac arrhythmia with an estimated five million cases globally. This condition increases the likelihood of developing cardiovascular complications such as thromboembolic events, with a fivefold increase in risk of both heart failure and stroke. Contempo-rary challenges include better understanding AF pathophysiology, and optimizing therapeutical options, due to current lack of efficacy and adverse effects of anti-arrhythmic drug therapy. Hence, the identification of novel biomarkers in biological samples would greatly impact the diagnostic and therapeutic opportunities offered to AF patients. Long non-coding RNAs, micro RNAs, circular RNAs and genes involved in heart cell differentiation are particularly relevant to understanding gene regulatory effects on AF pathophysiology. Proteomic remodelling may also play an important role in the structural, electrical, ion channel and interactome dysfunctions associate with AF patho-genesis. Different devices for processing RNA and proteomic samples vary from RNA sequencing, microarray to a wide range of mass spectrometry techniques such as Orbitrap, Quadrupole, LC-MS and hybrid systems. Since AF atrial tissue samples require a more invasive approach to be retrieved and analysed, blood plasma biomarkers were also considered. A range of different sample pre-processing techniques and bioinformatic methods across studies were examined. The objective of this descriptive review is to examine the most recent developments of transcriptomics, proteomics and bioinformatics in Atrial Fibrillation.
MOUNTAIN Precision AgriculturE Index: A Review
Authors: Covaci Brindusa , Covaci Mihai , Brejea Radu
Published: January 2025

The paper develops the Mountain Precision Agriculture Index realized in 2020 at Oradea University – Doctoral School, Agronomy Specialization (Covaci-Sterpu, 2020). The article points the importance of entrepreneurship development, focusing on precision agriculture index in the mountain area. The reviewed papers show that the implementation of precision farming within an IoT framework in highland regions (ζ9) must be developed with attention to various essential aspects, precisely the elevation of the mountain (ζ1), the gradient of the terrain (ζ2), the mean local altitude (ζ3), signal degradation due to the mountainous topography (ζ4), access to internet connectivity (ζ6), the level of smart technology utilization (ζ7), and the concentration of active ICT businesses in the region (ζ8). The current paper show that ζ9 is dependent of other indices too, respectively the interaction with the intensity of geomagnetic storms or weather shortcomings (ζ5).The paper presents a specific map of the mountain peaks from the European area, highlighting the importance of the altitude in applying the precision agriculture index.The paper is a review of the articles Covaci, B., & Covaci, M. (2023). Mountain Index Business Model Nexus Internet of Things Development and Sustainability. J. Mountain Res. Vol. 18(2), 191-205 (https://doi.org/10.51220/jmr.v18i2.21) and Covaci, B., & Covaci, M. (2023). Systemic Practice in the Business Mountain Models nexus Internet of Things, Research Square (https://doi.org/10.21203/rs.3.rs-2682687/v1).