bluuebunny/crossref_metadata_2025 huggingface dataset:
Scalable Ligand-Receptor Binding Affinity Landscape: A Case Study with Ziconotide and CaV2.2
Authors: Li Wei
Published: September 2024

The optimization of ligand-receptor binding affinities is essential for enhancing therapeutic efficacy and specificity, particularly in the design of peptide-based drugs. ziconotide, a potent blocker of the N-type calcium channel CaV2.2, has demonstrated therapeutic potential in the treatment of moderate to severe chronic pain. However, there is limited structural and binding affinity data available for scaling the design of ziconotide analogues with improved efficacy and specificity. In this study, I present a structural biophysics-based approach to develop a scalable in silico framework for generating and analyzing ligand-receptor binding affinity landscapes, focusing on ziconotide and its receptor, CaV2.2. This framework integrates advanced computational structural tools and binding affinity calculations to produce high-accuracy structural and intermolecular binding data. The insights gained from this scalable approach will guide the design of ziconotide analogues with enhanced efficacy, offering a powerful computational workflow for high-throughput ligand optimization. Additionally, when combined with artificial intelligence (AI) algorithms, this computational workflow generates high-accuracy structural and biophysical data, towards an AI- and structural biophysics-driven paradigm shift in peptide discovery and design.
Paradoxes in Telemedicine Services: Analysis of Challenges and Opportunities for the Future of Digital Health - A Systematic Literature Review
Authors: Binsar Faisal , Hamsal Mohammad , Ediansyah Ediansyah
Published: September 2024

Telemedicine has become an interesting research topic in recent years, especially since the start of the COVID-19 pandemic. This article conducts research using a systematic literature review to identify paradoxes in telemedicine services. The research method follows the steps in a systematic literature review, by accessing the Scopus journal database to search for relevant articles between 2018 and 2024. The selected articles were selected based on certain inclusion and exclusion criteria, resulting in 28 relevant articles which were then analyzed to understand findings related to paradoxes in telemedicine services. The research results show four main clusters of paradoxes in telemedicine research, namely health services, health quality, the COVID-19 pandemic, and technology. Each cluster shows complex opportunities and challenges in efforts to improve health services through telemedicine. Understanding the clusters for each article can then be mapped to the organizational categories in the Dynamic Equilibrium Model. In conclusion, this study provides a comprehensive insight into the paradoxes in telemedicine services, highlighting the importance of understanding the various aspects involved in the adoption and implementation of this technology. With a better understanding of this paradox, it is hoped that society and health practitioners can overcome the challenges and exploit the opportunities offered by telemedicine to improve the accessibility and quality of health services in the future.
Evaluating the Impact of Cloud Computing on SMEs Performance: A Systematic Review
Authors: Mkhize Ayaphila , Mokhothu Katleho , Tshikhotho Mukhodeni , Thango Bonginkosi
Published: September 2024

In recent times, the adoption of cloud computing by small and medium-sized 9 enterprises (SMEs) has become a crucial issue. These businesses face substantial difficulties in 10 accessing reliable and affordable IT infrastructure due to economic constraints and technological 11 restrictions. Hybrid cloud computing solutions which incorporate Infrastructure as a Service 12 (IaaS), Platform as a Service (PaaS), and Software as a Service (SaaS) offer a feasible approach to 13overcoming these challenges. This study proposes a systematic literature review of cloud 14 computing's impact on SME performance emphasizing cost-efficiency, reliability, and 15 competitive advantages, using the 2020 Preferred Reporting Items for Systematic Reviews and 16 Meta-Analyses (PRISMA) framework. The inclusion criteria are bounded by (1) publication date 17 between 2014 and 2024, (2) English-language publications, (3) research focused on cloud 18 computing for SMEs, and (4) studies with a clear analytical framework for evaluating SME 19 performance. Following this process, 90 eligible research studies were included. The average 20 total cost for cloud services varies significantly, with operational costs reflecting the scalability 21 of the services and the specific needs of SMEs. This analysis offers valuable guidance for SMEs 22 and stakeholders in optimizing cloud-based strategies for enhanced performance.
Health Literacy in Africa – A Scoping Review
Authors: Sørensen Kristine , Knoll Verena , Ramos Neida , Boateng Millicent , Almeyehu Guda , Schamberger Laura , Harsch Stefanie
Published: September 2024

Africa's health landscape is rapidly changing, requiring new solutions such as a focus on health literacy. However, there is currently a limited overview of the development and application of health literacy in African countries and societies. To inform progress, a scoping review was conducted, including a systematic literature search of research approaches, historical developments, geographic origins, target populations and settings, and topical interests. 336 articles were retrieved from six databases following PRISMA guidelines. Sources identified included reports, policy briefs, book chapters, and research publications. The analysis provided the most comprehensive overview of the current scope and scale of health literacy in Africa to date. The publications represented 38 of the 54 African Union countries and dated back to 2001, although most were published in the last decade. The content analysis identified 13 broad themes, including mental health, communicable diseases, non-communicable diseases, maternal health, digital health, information and communication, health care, prevention and health promotion, conceptual perspectives, cultural perspectives, outcomes and measurement. The stakeholder analysis revealed a wide range of actors involved in different settings, mostly in health care or community settings. These comprehensive and novel findings can be used to prioritize future actions for public and professional capacity building, policy development and improved practice to improve health literacy for all in Africa.
Derivation of Analytical Equations for the Fundamental Period of Framed Structures Using Machine Learning and SHAP Values
Authors: Karampinis Ioannis , Morfidis Konstaninos , Iliadis Lazaros
Published: September 2024

The fundamental period is one of the most important parameters for the design of new structures , as well as the estimation of the capacity of existing ones. However, its calculation requires the solution of an eigenvalue problem. Especially for new buildings, this can involve material and geometric parameters that are not known beforehand. Thus, to estimate it, various design codes and researchers have adopted a several approximate analytical equations based on a number of key structural parameters. To this end, the present study introduces a novel methodology for the derivation of analytical equations for the fundamental period of Reinforced Concrete (RC) structures. The methodology is based on Machine Learning (ML) explainability techniques and specifically the so-called SHapley Additive exPlanations (SHAP) values. The novel methodology allows these equations to be constructed sequentially and in an informed manner, controlling the balance between accuracy and complexity. An extended dataset comprised of 4026 data points is employed. The results showed excellent accuracy, with a coefficient of determination R2≈0.95. This demonstrates the potential applicability of the proposed methodology in a wide array of similar engineering challenges.
Theoretical Study of The Halogen Concentration Effect on The 1,3-Butadiene Polymerization Catalyzed by the Neodymium-Based Ziegler–Natta System
Authors: Masliy Alexey N. , Akhmetov Ildar G. , Kuznetsov Andrey M. , Davletbaeva Ilsiya M.
Published: September 2024

In this work, an attempt is made to the theoretically substantiate the experimentally known facts of the influence of halogen concentration on the catalytic properties of the neodymium-based Ziegler–Natta system. Based on the structural and thermochemical data obtained using modern methods of quantum chemistry, the process of the 1,3-butadiene cis-1,4-polymerization under the model active centers of the neodymium Ziegler-Natta catalysts with different content of chloride ions was studied. Results are presented that explain the increase in the cis-stereospecificity and activity of the polymerization system with an increase in the content of the chloride ions in the neodymium catalytic system. There were established the reasons for the decrease in the concentration of active centers relative to the introduced Nd(III) with an excess of chloride ions and the occurrence of the anti-syn isomerization as a source of the formation of the trans-1,4-structures in the cis-1,4-polybutadiene.
Development of a Risk Predictive Model for Erectile Dysfunction at 12 months after COVID-19 Recovery: A Prospective Observational Study
Authors: Natal Alvarez Fernando , Conde Redondo Maria Consuelo , Sierrasesumaga Martin Nicolas , Garcia Viña Alejandro , Marfil Peña Carmen , Bahillo Martinez Alfonso , Jojoa Mario , Tamayo Gomez Eduardo
Published: September 2024

Objectives: To develop a risk prediction model for the identification of features involved in the prediction of erectile dysfunction (ED) at 12 months following COVID-19 recovery. Methods: We performed an observational prospective multicentre study. Participants were classified according to their history of COVID-19: I) Patients with a past history of COVID-19; and II) Patients without a previous microbiological diagnosis of COVID-19. A total of 361 patients (Past history of COVID-19, n=166; No past history of COVID-19, n=195) were assessed from January 2022 to March 2023. Patients with a past history of COVID-19 were assessed at 12 months following COVID-19 recovery. The primary outcome measure was ED, assessed through the 5-item International Index of Erectile Function (IIEF-5). Data concerning epidemiologic variables, comorbidities and active treatment were also collected. We performed a binary logistic regression to develop a risk predictive model. Among the models developed, we selected the one with the higher Area Under the Curve (AUC). Results: The median age was 55 years in both groups. The ED prevalence was 55.9% in patients with past history of COVID-19 and 44.1% in those with no past history of COVID-19. The best predictive model developed for ED comprised 40 variables and had an AUC of 0.8. Conclusions: We developed a regression model for the prediction of ED 12 months after COVID-19 recovery. The application of our predictive tool in a community setting could eventually prevent the adverse effects of ED on cardiovascular health, and the associated unfavourable economic impact.
Dust Monitoring and Three-Dimensional Transport Characteristics of Dust Aerosol in Beijing, Tianjin, and Hebei
Authors: Zhang Siqin , Wu Jianjun , Yao Jiaqi , Quan Xuefeng , Zhai Haoran , Lu Qingkai , Xia Haobin , Wang Mengran , Guo Jinquan
Published: September 2024

Global dust events have become more frequent due to climate change and increased human activity, significantly impacting air quality and human health. Previous studies have often focused on simulating cross-regional dust transport based on atmospheric parameters; however, comprehensive monitoring of dust events remains challenging. Therefore, this study utilized Fengyun-4A (FY-4A) satellite Advanced Geostationary Radiation Imager (AGRI) imagery, Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observation (CALIPSO) lidar, and other auxiliary data to conduct three-dimensional spatiotemporal monitoring and cross-regional transport analysis of two typical dust events in the Beijing–Tianjin–Hebei (BTH) region of China using four dust intensity indices (Icsd, Dust Detection Index (DDI), Dust value (DV), and Dust Strength Index (DSI)) and the HYSPLIT model. We found that among the four indices, DDI was the most suitable for studying dust in the BTH region, with a detection accuracy (POCD) of > 88% at all times and reaching a maximum of 96.14%. Both the 2021 and 2023 dust events originated from large-scale deforestation in southern Mongolia and the border area of Inner Mongolia, with dust plumes distributed between 2 and 12 km being transported across regions to the BTH area. Further, when dust aerosols are primarily concentrated below 4 km and PM10 concentrations consistently exceed 600 µg/m³, large dust storms are more likely to occur in the BTH region. The findings of this study provide valuable insights into the sources, transport pathways, and environmental impacts of dust aerosols.
Improving the organization of dispensary observation of patients with chronic dermatosis.
Authors:   Bashkir State Medical University, Sharafutdinova N.Kh. , Mukhamadeeva O.R. ,   Bashkir State Medical University, Khalfin R.M. ,   Bashkir State Medical University
Published: September 2024

One of the most important sections of a doctor’s work is the organization of dispensary observation of patients with chronic diseases. To ensure the necessary volume and quality of dispensary observation for patients with chronic dermatoses, an integrated approach is required. The purpose of our study was to develop and evaluate the effectiveness of measures to improve the organization of dispensary observation of patients with psoriasis. Materials and methods. To improve dispensary observation of patients with psoriasis, we have developed a set of measures. The effectiveness of the implemented measures was assessed in two groups of patients with psoriasis living in rural areas. The first group – patients before the implementation of the proposed measures (145 patients), the second group – after the implementation of the proposed measures (168 patients). In both groups, patients’ adherence to treatment, the quality of clinical supervision and the quality of life of patients were assessed. The opinion of doctors about the results of the measures implemented in their work was studied. Results. The introduction of measures to improve dispensary observation of patients with psoriasis in the work of medical organizations of the Republic of Bashkortostan has shown their effectiveness. The number of patients with improvement in the second group was 78.6±3.2%, and in the first group it was one third less – 51.0±4.2% (p<0.001), and the number of patients without changes in condition, on the contrary, was greater in the first group was 37.9±4.0% and 10.3±2.5%, than in the second group – 15.5±2.8% and 5.4±1.7% (p<0.001). There was an increase in the coverage of patients with dispensary observation by 61.7%, a decrease in the number of patients with relapses of the disease by 36.5%, a decrease in the number of hospitalizations for exacerbation of the disease by 46.1%, an increase by 34.2%. with coverage of anti-relapse outpatient treatment, the number of days of temporary disability decreased by 42.4%, compliance and the level of quality of life increased. According to the surveyed doctors, the implemented measures had a positive impact on the work with patients of the dispensary group. Conclusion. Thus, the set of proposed measures to improve dispensary observation of patients with psoriasis has shown its effectiveness and can be recommended for further implementation in medical organizations providing medical care to patients with chronic dermatoses.
On the need to increase the level of navigation literacy of the population in modern healthcare (review).
Authors:   Orenburg State Medical University of the Ministry of Health of the Russian Federation, Begun D. N. , Bulychev V. V. ,   State budgetary institution of health care «Orenburg Regional Clinical Tuberculosis Dispensary», Bulycheva E. V. ,   Orenburg State Medical University of the Ministry of Health of the Russian Federation, Borshchuk E. L. ,   Orenburg State Medical University of the Ministry of Health of the Russian Federation
Published: September 2024

Currently, the medical scientific community recognizes the fact that the navigational literacy of the population complements the effectiveness of healthcare by increasing the adequacy of interaction among all participants: consumers and providers of medical services. Improving the level of navigation literacy of the population is an urgent strategy that can help the population to find the necessary support in the health system and gain access to it. T h e p u r p o s e o f t h e s t u d y is to analyze the published data in the scientific literature on the need to increase the level of navigation literacy of the population in modern healthcare. M a t e r i a l s a n d m e t h o d s . The collection, study and analysis of available information sources in the scientometric databases WoS,Scopus. The search for scientific articles was carried out in the electronic databases PubMed, Google Scholar, eLibrary.RU by keywords. 64 articles were included in the review for analysis. R e s u l t s . The multilevel and multidimensional organization of the modern healthcare system creates difficulties for the population in navigation and effective use of medical services, search, interpretation of information necessary for navigation. The published research results in the scientific literature indicate the need to analyze in detail the navigation literacy of the population in order to more effectively solve the identified problem. Key adjustments in relation to improving the navigation literacy of the population are possible only with its active study directly among all those who directly interact with the health care system as a consumer of medical services. The study of navigation literacy of the population is currently a fairly young, little-studied and promising area in the field of public health and public health. F i n d i n g s . Increasing the level of navigation literacy of the population in the modern healthcare system is an urgent issue. Currently, it is necessary to expand the understanding of its level and characteristics in various cohorts of the population in order to develop effective programs on this issue.
Los observatorios turísticos como organismos claves para la gestión de destinos
Authors: DOUMET CHILÁN NEME YAMIL , CRUZ ROMERO BARTOLO , TORRES APOLO DAILY , ALCÍVAR ALAVA FERDINAN
Published: September 2024

Este trabajo tiene como objetivo,fundamentar mediante un diagnóstico la necesidad e importancia de un observatorio turístico en la región norte de la provincia de Manabí (Ecuador), obteniendo, asimismo, conclusiones trasladables a otros destinos regionales. La investigación es de carácter mixto, con enfoque exploratorio descriptivo. Primero se buscó caracterizar el territorio, identificando sus componentes turísticos y mediante la técnica de revisión bibliográfica y documental, se analizaron las estadísticas nacionales y regionales sobre economía y turismo, confirmando que Manabí posee un 10% de las empresas de alojamiento y restaurantes del país, cuya principal modalidad es el turismo de sol y playa, además de cuantificar una oferta de hospedaje de 6.176 plazas. Posteriormente, se realizó un análisis de la percepción de los gestores sobre el interés en la creación de un observatorio turístico mediante 30 encuestas aplicadas en los ocho cantones estudiados, implementándose un análisis estadístico descriptivo utilizando la herramienta Google forms y el software de análisis estadístico SPSS para su sistematización. El estudio demuestra que el 82.5% de los encuestados tienen interés en proporcionar información disponible sobre la oferta y demanda y el 38.60% acepta ayudar con la aplicación de instrumentos para el levantamiento de datos. Se pudo evidenciar la carencia de información y la necesidad de un observatorio turístico para el uso de datos actualizados y fiables fomentando la adecuada gestión de los destinos en la zona norte de Manabí. 
Palabras clave: Información turística, gestión eficiente, observatorios turísticos, destinos.
La creación y diseño de centros de información turística: una propuesta en Barrancas del Cobre (México)
Authors: GONZÁLEZ CANTÚ PAOLA ISMENA , TOSCANO MOCTEZUMA JUAN ALFONSO , GONZÁLEZ HERRERA MANUEL RAMÓN
Published: September 2024

La presente investigación realiza una propuesta de creación y diseño de un centro de información turística de cara a una posible candidatura de Barrancas del Cobre como Geoparque Mundial de la UNESCO. Dentro de los lineamientos de dicho programa se encuentran diversos criterios muy específicos acerca de la operación del área que desea este reconocimiento. En ellos se encuentra que son necesarias prácticas de conservación del patrimonio y un centro de información para los visitantes, debido a que Barrancas del Cobre no cuenta con estas necesidades básicas. De esta manera, se propone un centro de información que permita el registro de visitantes y, por ende, pueda realizarse un estudio de capacidad de carga, además de proponer que dicho registro de visitantes se haga por medio de una aplicación móvil. La metodología usada para la investigación fue de tipo cualitativa y se empleó la técnica de revisión de la literatura y el método analítico y comparativo con casos prácticos, todo contrarrestado y basado en los estándares de la UNESCO.
Palabras clave: Gestión de destinos turísticos, centros de información turística, sustentabilidad, uso de tecnologías
A study on the investigation of awareness of health employees about Medical Tourism in Turkey
Authors: DÖKME SEMA , YAGAR FEDAYI , PARLAYAN MEHMET ALI
Published: September 2024

This study aims to determine the level of awareness of the healthcare personnel regarding the medical tourism. The study was conducted with healthcare professionals working in two private hospitals between February 20, 2016 and April 20, 2016. Within the scope of the study, 292 healthcare professionals were reached and SPSS 20.0 program was used in the analysis of the data. In the study, it was determined that the healthcare professionals have sufficient knowledge about medical tourism, do not show favoritism towards domestic or foreign customers, trust their hospitals' physicians, technical equipment and service quality, and that they only lack in foreign language skills. As a result, it was emphasized that it is necessary to establish a separate unit on medical tourism in hospitals, to improve the foreign language skills of the personnel in the shortest period of time, to make effective promotions to target markets, and to ensure that the unit participate in fairs and congresses as necessary.
Keywords:
Medical Tourism, Health Employees, Private Hospitals, Turkye.
La significación del Parque Museo “La Venta” como producto de turismo cultural en Tabasco (México)
Authors: PÉREZ SÁNCHEZ BEATRIZ , GARCÍA MUÑOZ APARICIO CECILIA
Published: September 2024

La evolución de la cultura Olmeca, primera civilización de Mesoamérica, heredó a México el patrimonio de su arquitectura, fiestas, rituales, artesanías, gastronomía y lenguas que surgieron de su diversificación.  En Tabasco se edificó y se resguarda el centro ceremonial más antiguo cuyo esplendor se remonta a los años 800-400 a.C. Una simbología que es parte del turismo cultural de Tabasco que fundó el 4 de marzo de 1958 el Parque Museo La Venta, en Villahermosa, un patrimonio de la cultura que constituye una organización civilizadora con elementos de identidad y una atracción turística que brinda autenticidad histórica y prehispánica. Ofrece desde hace más de 60 años un destino arqueológico innovador, diseñado en medio de la naturaleza, de un trópico húmedo con su flora y su fauna original. Objetivo: demostrar la importancia del Parque Museo La Venta como parte del turismo cultural en Tabasco México. Metodología: En esta investigación se utilizará un método de tipo cualitativo descriptivo con el manejo de fuentes secundarias. Resultados: bajo la tutela del Estado mexicano se determinó en toda su amplitud la noción de museo y la creación del Parque Museo La Venta bajo la mercantilización de la cultura.
Palabras Clave:  Parque Museo La Venta, turismo cultural, Tabasco, México.
Diseño experimental de una empresa de aviturismo en la Reserva Internacional de la Biosfera “Sierra La Laguna” (México)
Authors: GARCÍA DE LA FUENTE JOSÉ EMER , OJEDA-RUIZ MIGUEL ÁNGEL , LACRUHY-ENRÍQUEZ CLAUDIA , RAMÍREZ-PÉREZ JORGE SAÚL
Published: September 2024

Ante la pérdida del capital natural el desarrollo y la planificación de las Áreas Protegidas (ANPs) se ha convertido en una estrategia para la conservación y valorización de los ecosistemas, la biodiversidad y la sustentabilidad ambiental y social. Baja California Sur, Estado de mayor extensión bajo protección, alberga la Reserva de la Biosfera Sierra La Laguna (REBIOSLA), destacada por salvaguardar ecosistemas y especies únicas y recargar acuíferos, contribuyendo al desarrollo de los principales municipios. La falta de recursos presupuestalrios para sustentar la ANP y para desarrollar actividades económicas amenazan a las comunidades locales y a la operatividad de la reserva. El proyecto desarrolló de forma participativa con pobladores una estrategia de diversificación económica sustentable y responsable del patrimonio cultural y natural, implementando un emprendimiento social, donde el aviturismo es primordial. Este estudio se fundamento en estudios y diálogos horizontales para documentar el capital avifaunístico de la zona y en encuestas para determinar aspectos socio-económicos y talleres participativos. Se desarrolla aquí un modelo de negocio y unas estrategias de organización y mercadotecnia, elementos claves de la imagen corporativa. Asimismo, se establece la organización de la empresa y su plan de negocios, a la vez que se delimitan unos senderos considerando y reduciendo impactos en hábitats, elaborando una guía rápida de aves regional, capacitando a guías locales y creando una página web de apoyo.
Palabras Clave: Sierra la Laguna, observación de aves, emprendimiento social, actividades alternativas, diversificación económica, empresa comunitaria.
El desarrollo del turismo idiomático en Playa del Carmen, Quintana Roo- México, durante el período 1997-2023
Authors: MEDINA LÓPEZ SUSANA
Published: September 2024

A nivel internacional el idioma español es un atractivo turístico consolidado que mediante oferentes de servicios de enseñanza de Español como Lengua Extranjera (ELE) potencia el desarrollo local; pero se desconocen las características de tal oferta en Quintana Roo, México. Así, el objetivo es analizar el origen, evolución y estado actual de la enseñanza de ELE en empresas de Playa del Carmen (PDC). El diseño del estudio es retrospectivo con alcance exploratorio. La información se obtuvo con entrevistas semiestructuradas, observación participante y búsqueda documental. En 1997 se inició la actividad empresarial de enseñanza de ELE en PDC conformada 100% por micronegocios y transitó hacia un mercado de corporaciones transnacionales y micronegocios en 40% y 60% respectivamente. Ofrecen cursos intensivos principalmente y servicios complementarios como: alojamiento con familias; clases de baile y cocina, y excursiones. La afluencia de estudiantes tiene una estacionalidad diferente a la del turismo convencional y su estancia promedio (tres semanas) triplica la del turismo general. Aunque algunos resultados coinciden con los reportados sobre este tipo de escuelas, requieren conocerse más elementos como el perfil socioeconómico y comportamiento de este turista idiomático en PDC y si favorecen el desarrollo local, incluir este segmento en estratégicas de diversificación turística.
Palabras clave: turismo lingüístico; turismo cultural; historia social; patrimonio cultural intangible; desarrollo local; turismo sostenible; enseñanza de ELE; Playa del Carmen.
The power of cultural heritage in tourism. Example of the city of Zadar (Croatia)
Authors: GLUVACEVI´C DEJAN
Published: September 2024

Today, in 21th century when many destinations try to manage with own identity and image to achieve bigger income and other benefits. For that it is necessary competitive identity, as Simon Anholt called it, as well as tourism which is by him most 'loudest' and powerful channel of communication. To gain competitive identity that will be communicated through tourism is usually done using the power of culture - either popular culture or cultural heritage. As all destinations have his own history and specific cultural heritage, cultural heritage can be advantage for many destinations if they can recognize its uniqueness and advantages comparing to other competing destinations. The purpose of this paper is to see whether the cultural heritage is enough strong trump to set the city of Zadar (Croatia) as a city which could build their tourism brand on cultural heritage. The city of Zadar is a city with a very long and turbulent history which can provide to the city to create competitive identity. So far, Zadar achieves positive results within the context of Croatian tourism, but the question is whether and how to achieve even better results? The results obrained from the questionnaires will show us how powerful is cultural heritage of Zadar to attract tourists to Zadar and what tourists think about cultural heritage in Zadar.
Keywords: cultural heritage, competitive identity, tourism, Zadar, Croatia.
Ventajas del proceso de digitalización hotelera: un estudio de caso experimental
Authors: FONDEVILA-GASCÓN JOAN-FRANCESC , BOSCH-VILARRUBIAS MARTA , PUIGGRÒS ELENA , PÉREZ-RECOUSO JOAQUIN-ELÍAS
Published: September 2024

El proceso de digitalización en el sector turístico y, específicamente, en el hotelero, lleva realizándose desde hace unos años, aunque la cuantificación de las ventajas que se derivan de ello no es habitual en entornos científicos. La mayor parte de cadenas hoteleras, y también hoteles independientes, han evolucionado desde un sistema de gestión manual y analógico a un software centralizado que optimiza todas las operaciones, reduciendo la carga de trabajo y los errores. La industria hotelera es cada vez más propensa a esa mejora de las operaciones da raíz de la digitalización, que incluye acceso a banda ancha y programas de gestión. En esta investigación se utiliza una metodología de carácter exploratorio (estudio de caso), experimental (implementación real de procesos de digitalización) y la técnica cualitativa de las entrevistas en profundidad y análisis de contenido y cuantitativa de la encuesta (datos secundarios procedentes del establecimiento hotelero). Se analiza el impacto de la digitalización en un hotel ubicado en Tarragona (España). Los datos se recopilan a través de entrevistas con miembros del personal, además de utilizar datos provenientes de encuestas a los clientes y análisis de los registros financieros hoteleros. Los resultados revelan que la digitalización de las operaciones conlleva más eficiencia, reducción de costos y mejora en la satisfacción del cliente. El sistema centralizado permite al personal gestionar reservas, inventario y facturación en tiempo real, lo que mejora la toma de decisiones y el control sobre las operaciones. Se concluye que las mejoras operativas y financieras son significativas, y que la digitalización es el camino a seguir para la industria hotelera para mejorar operaciones y rendimiento financiero.
Palabras Clave: Sociedad de la Banda Ancha, digitalización, turismo, conectividad, gestión, operaciones, eficiencia, hospitalidad.
The pursuit of difference as a reason for travelling decisions
Authors: REEH TOBIAS , KREISEL WERNER
Published: September 2024

The pursuit of difference is regarded as an important stimulus for travelling decisions within the German-speaking tourism geography (Hopfinger 2007; Reeh 2011). In order to lay the ground for adopting this concept in future empirical studies, this article suggests a few thoughts on both perspectives for a theoretical foundation and an operational model to use the concept of the pursuit of difference in tourism research.
Keywords: Tourist motivations; Trips; Tourism Geography; Germany; Theoretical reflections.
WITHDRAWN: Catecholamines in healthy and inflamed pulp of primary teeth
Authors: Damle Satyawan G , Chopal Nilika , Kamboj Gaurav , Dhindsa Abhishek , Sakhare Dhanashree , Dasgupta Shreya
Published: September 2024

The full text of this preprint has been withdrawn by the authors due to author disagreement with the posting of the preprint. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
CircPSD3 Aggravates Tumor Progression by Maintaining TCA Cycle and Mitochondrial Function via Regulating SUCLG2 in Thyroid Carcinoma
Authors: Hong Shubin , Sun Yijia , Han Beinan , Ge Jiawei , Huo Zijun , Li Jin , Lin Bo , Du Xin , Zhang Yimin , Weng Haiyan , Yu Shuang , Li Yanbing , Xiao Haipeng , Lin Xiaorong
Published: September 2024

In recent years, there has been a rapid increase in the incidence of thyroid carcinoma (TC). Our study focuses on the regulatory effect of circular RNAs on metabolism of TC, aiming to provide new insights into the mechanisms of progression and a potential therapeutic target for TC. In this study, we identified high expression levels of circPSD3 in TC tissues through RNA sequencing. Papillary thyroid cancer tissue cohorts verified the circPSD3 expression level was positively correlated with larger tumor size. circPSD3 promoted the proliferation of TC cells and reduced apoptosis both in vitro and vivo. Proteomics and metabolomics suggested that circPSD3 might play a crucial role in regulating the tricarboxylic acid (TCA) cycle. Specifically, circPSD3 acted as a miR-338-5p sponge to upregulate SUCLG2, an enzyme of the TCA cycle, accelerates the conversion of α-ketoglutarate (α-KG) to succinate. Knockdown of circPSD3 disrupts the TCA cycle and impairs mitochondrial function, resulting in decreased membrane potential and aerobic respiration rate. The reduction in mitochondrial function resulted in the inhibition of proliferation and initiation of mitochondria-mediated apoptosis.
Construction and Application of Geographic Knowledge Graph for Landslide Disaster Emergency
Authors: Zhao Xiangwei , Kong Xianghui , Zhao Huiji , Gao Lei , Niu Chong
Published: September 2024

Landslide is a common geological disaster worldwide, causing significant harm to human lives, socio-economic development, and the ecological environment. Effective emergency response to landslide requires coordination among multiple departments, while the complex terrain and dam aged roads at disaster sites increase the difficulty of rescue operations. Geographic knowledge graph technology can represent multiple disaster response data in graph form to highlight the complete relationships between the integrated entities. It enhances systematic processing of disaster information to provide scientific decision support for emergency responses. The previous studies on knowledge graph for landslide disaster emergency focused on cause analysis and spatio temporal evolution by using textual data. However, they lacked descriptions of spatial relationships and systematic analysis, which limited their practical application. To solve this problem, a geographic knowledge graph was proposed for landslide emergency response and was implemented in Zhouqu County in China, a region prone to landslides. Firstly, a unified ontology framework was defined, including three ontology concepts named as static base map layer, real-time data layer, and domain information layer, along with spatial, hierarchical, and semantic relationships. Then, the entities, relationships among them, and their attributes were extracted from the data of road networks, emergency response points of interest, and real-time data to form two types of triples including entity-relationship-entity and entity-attribute-value. Next, the ontology alignment methods were applied to eliminate redundant information. The triples were mapped into the unified ontology framework and stored in the Neo4j graph database, forming the geographic knowledge graph for landslide emergency response. Finally, the geographic knowledge graph was used for landslide emergency task assignment and route planning. The experimental results showed that
the geographic knowledge graph for landslide emergency response can be effectively extracted and constructed based on the proposed method by integrating multiple spatial data, and it can perform well for decision support.
Method for assessing the height and three-dimensional spatial development characteristics of water-conducting fissure zones in integrated medium-thickness coal seam mining
Authors: zhao lijuan , zhou junqian , gao mingzhong , wang xingui , duan hongfei , lv wenling , Yu Zhenjian , xie jing , cui pengfei , hu jianjun , Hao Haichun , chi mingbo
Published: September 2024

It is of great significance to accurately grasp the development height of the water-conducting fissure zone (WCFZ) in the rock layer overlying mining airspace, which is of great importance for achieving safe mining of the working face in a mine. In this paper, data on the distribution characteristics of the WCFZs in 40 mines in China were collected, and multivariate linear fitting analysis of the data was carried out using the SPSS software to establish a prediction model for the height of a WCFZ in integrated medium-thickness coal seam mining. Taking working face 2108 in the Heilongguan Coal Mine in Shanxi as the research object, the quantitative interpretation of the development height and distribution characteristics of the WCFZ in the rock overlying the mining airspace was carried out using the method of actual measurement of the amount of leakage of water injected through the drilling holes and the fast Lagrangian code in 3 dimensions (FLAC3D) numerical simulation method to verify the validity of the prediction model for the height of the WCFZ in comprehensive medium-thickness coal seam mining. The study shows that A multivariate linear regression model for calculating the height of a WCFZ was established.The maximum vertical heights of the plastic deformation zones obtained from field tests of water injection leakage in actual engineering boreholes and numerical simulation methods are basically consistent with the results of the model proposed in this paper. the height and spatial development morphology of the WCFZ obtained using the three methods are in good agreement.
Parents care needs with epileptic children: a hybrid model concept analysis
Authors: Khalili Arash , Cheraghi Fatemeh , Fayyazi Afshin , Soltanian Alireza , Shamsaei Farshid
Published: September 2024

Background The care needs of epileptic children are a multidimensional concept that varies based on the experience and understanding of family caregivers. This study aimed to concept analysis the care needs of epileptic children's parents.Methods This study was conducted using the hybrid method in three phases. The available literature was systematically searched in the theoretical phase. In the fieldwork phase with a qualitative approach, 13 parents caring for epileptic children were investigated with individual and semi-structured interviews at the Besat Teaching-Treatment Center (Hamadan, Iran) in 2024. In the final phase, the concept of parental care needs was defined based on the findings of the theoretical and fieldwork phases.Results The common antecedents of the theoretical and fieldwork phases included low education levels and poor economic status, and the antecedent of ineffective supporters appeared in the fieldwork phase. The common consequences were care quality improvement, financial burden reduction, care knowledge acquisition, and psychosocial status improvement, and the consequence of increasing stability in the family structure appeared in the fieldwork phase. The care needs of epileptic children's parents included the need for comprehensive support, financial challenges, low care knowledge, therapeutic needs, and psychological challenges. These needs are affected by factors such as poor economic status and low education, and their fulfillment leads to improved quality of life and more effective disease management.Conclusion Concentration on parental care needs and provision of appropriate support through education, financial resources, and social support can help reduce psychosocial pressures on families.
Comparing the effectiveness of CBM treatment and TACS treatment on anxiety, depression, attentional bias, and craving in individuals with opioid use disorder attending addiction treatment camps
Authors: Papia Kiyanoosh , Nosratabadi Masoud , Taremian Farhad , varkiyani Maryam Ebrahimi , Ghanbari Nikzad , docheshmeh Amir Mohamad
Published: September 2024

Introduction:
Substance abuse, especially of opium, represents a major challenge in modern societies, not only impacting individuals' physical and mental health but also giving rise to social problems.
Objective
This research aimed to compare the effectiveness of two treatment methods, CBM (Cognitive Bias Modification) and TACS (Transcranial Alternating Current Stimulation), on reducing anxiety, depression, attentional bias, and craving in individuals with opioid use disorder.
Methods
This study was an experimental research with a pre-test and post-test design. The participants of this study were 72 individuals attending addiction treatment camps who were systematically selected and divided into four treatment groups: CBM treatment, TACS treatment, a combination of both methods, and a control group. Data on demographics were collected using a demographic baseline form of substance abusers, to measure verbal craving induction and visual linear craving scale, and for current craving assessment, a substance craving questionnaire was used, while anxiety and depression levels of participants were measured using the anxiety and depression scale.
Results
The results of the study showed that both treatment methods significantly reduced anxiety and depression. Moreover, the combined CBM and TACS treatment had a greater impact on modifying attentional bias and reducing substance craving compared to each treatment method alone. Furthermore, the comparison between CBM and TACS methods did not show a significant difference in current or induced craving scales (p > 0.05). However, a significant difference was observed in cognitive bias modification (p = 0.012), depression (p = 0.002), and anxiety (p = 0.03) between the simultaneous transcranial electric stimulation and cognitive bias modification.
Discussion
These findings suggest that using a combination of treatment methods can have more efficacy in improving mental health status and reducing substance craving in individuals with opioid dependence.
Day care geriatric mental health services through social prescription by primary health care staff: A Randomized Control Trial at community centers, Chittoor district, A.P., India.
Authors: Tarugu Jayanthi , Koni Kiranmayi , Chaudhuri Sirshendu , KR John , M Krishna A
Published: September 2024

Background:
Health issues among the elderly are inevitable. Mental health problems are common among them and, it is one of the most neglected areas of health. There is a felt need to develop strategies to meet the needs of elderly. Social prescribing is an effective strategy to improve the health and wellbeing of elderly. Hence, this study is planned to estimate the effectiveness of day care geriatric mental health services through social prescription on quality of life (QOL) of elderly aged 60 years and above in rural communities of Chittoor district, Andhra Pradesh.
Methods:
It is a randomized controlled interventional trial, where elderly aged 60 years and above with no acute psychotic symptoms will be recruited from community areas of Chittoor district, Andhra Pradesh. Eligible elderly will be directed to day care geriatric mental health services, where interventions will be planned based on the need assessment. Follow up will be done once in two months to identify the challenges in continuing day care geriatric mental health services. Cost details will be collected concurrently. Analysis will be done applying both intention to treat (ITT) and per protocol analysis. To examine the association between the participant’s characteristics and their QOL, uni-variate analysis will be performed. Thematic analysis will be done to analyse qualitative data where themes and sub-themes will be identified.
Discussion
Mental health services in geriatric population are a neglected area. Day care geriatric mental health services are essential to improve the Quality of living and also their physical and mental health.
Trial registration:
CTRI/2023/03/050503 dated 09/03/2023 under clinical trials registry- India version:1.0 dated 09/03/2023.
Tumour immune cell infiltration and response to FOLFOX or FOLFIRI chemotherapy in colorectal cancer
Authors: Feng Jia , Zhang Lei , Zou You , Liu Rong
Published: September 2024

Background: The immune cell infiltration of tumors has been demonstrated to have a significant part in the response to different cancer treatments. We sought to gain greater understanding of the connections between the immune landscape of colorectal cancer (CRC) tumors and the clinical outcomes of infusional 5-fluorouracil/leucovorin with either oxaliplatin (FOLFOX) or irinotecan (FOLFIRI)-based chemotherapy.
Methods: The immune cell infiltration of CRC tumors was evaluated using data from the TCGA and GEO databases with the CIBERSORTx algorithm. The relative proportion of 22 immune cell subtypes was measured, and their associations with response, progression-free survival (PFS), and overall survival (OS) were investigated. Consensus clustering analysis was utilized for the identification of the immune cell patterns.
Results: We analyzed data from 387 CRC patients and found that drug response rates were negatively correlated with M1 macrophages in the context of FOLFOX chemotherapy. Poor PFS was linked to resting dendritic cells and eosinophils in this regimen. An inverse relationship between drug response rate and M0 macrophages was observed within the FOLFIRI chemotherapy regimen. Activated natural killer cells were connected to poor PFS and OS. Using consensus clustering analysis, we identified three immunological clusters, with a cluster associated with better medication response rates and improved patient outcomes following FOLFOX treatment. This cluster was characterized by higher proportions of M0 macrophages, quiescent memory CD4+ T cells, and quiescent B cells.
Conclusion: Our findings emphasize the significant impact of the CRC tumor-immune milieu on the response to FOLFOX or FOLFIRI chemotherapy. Further investigation of its regulatory mechanisms may contribute to advancements in therapeutic interventions.