bluuebunny/crossref_metadata_2025 huggingface dataset:
The Identification and Role of the Key Mycotoxin of Pestalotiopsis kenyana Causing Leaf Spot Disease of Zanthoxylum schinifolium
Authors: Liu Chang , Li Yiling , Chen Hang , Li Shuying , Han Shan , Zhu Tianhui , Liu Yinggao , Li Shujiang
Published: December 2023

Leaf spot is a common disease of Zanthoxylum schinifolium (Z. schinifolium), which can seriously harm the plant’s ability to grow, flower, and fruit. Therefore, it is important to identify the mechanism of leaf spot caused by Pestalotiopsis kenyana (P. kenyana) for thorough comprehension and disease control. In this study, to verify whether the mycotoxins produced by P. kenyana cause leaf spot disease, the best medium for P. kenyana, namely PDB, was used. The mycotoxins were determined by ammonium sulfate precipitation as non-protein substances. The crude mycotoxin of P. kenyana was prepared, and the optimal eluent was eluted with petroleum either/ethyle acetate (3:1, v/v) and purified by silica gel column chromatography and preparative high-performance liquid chromatography to obtain the pure mycotoxins PK-1, PK-2, and PK-3. The PK-3 had the highest toxicity to Z. schinifolium, which may be the primary mycotoxin, according to the biological activity test using the spray method. The physiological and biochemical indexes of Z. schinifolium plants treated with PK-3 mycotoxin were determined. Within 35 days after mycotoxin treatment, the results showed that the protein content and malondialdehyde content of leaves increased over time. The soluble sugar and chlorophyll content decreased over time. The superoxide dismutase activity and catalase activity of the leaves increased first and then decreased, and the above changes were the same as those of Z. schinifolium inoculated with the spore suspension of the pathogen. Therefore, it is believed that the mycotoxin pestalopyrone could be a virulence factor that helps P. kenyana induce the infection of Z. schinifolium. In this study, the pathogenic mechanism of Z. schinifolium leaf spot was discussed, offering a theoretical foundation for improved disease prevention and control.
Traction Properties of Aerospace Lubricant under Low-Temperature Micro-Oil Droplet Supply Conditions
Authors: Gao Fei , Tian Ling , Cui Yongcun , Zhao Yan , Su Bing , Sun Liming
Published: December 2023

Aerospace bearings need to withstand the low-temperature environment of space, which will cause changes in the internal lubrication state of the bearings. This article aims to assess the traction properties of aerospace lubricants under low-temperature micro-oil droplet (hereinafter referred to as ‘micro-oil’) supply conditions, and provide a lubrication theoretical basis for studying the motion characteristics of aerospace bearings in a low-temperature environment. An experimental study on the low-temperature micro-oil traction properties of high-speed bearing lubricants was conducted on a specially designed aerospace bearing lubricant traction characteristic tester. A modified Herschel–Bulkley model (modified H–B model) was presented based on test data analysis, and the fitting results were compared with the Tevaarwerk–Johnson model (T–J model). The findings demonstrated that the traction coefficient of this lubricant decreased at a higher load and entrainment velocity, and decreased with a decreasing inlet oil temperature from 0 °C to −50 °C. The modified H–B model accurately fitted the test data and was suitable for the engineering traction coefficient calculation of lubricants and high viscosities at low temperatures. This paper can provide fundamental information for analyzing aerospace bearing friction torque variation.
A Thermal Hydrodynamic Model for Emulsified Oil-Lubricated Tilting-Pad Thrust Bearings
Authors: Ouyang Wu , Yan Ziyang , Zhou Xincong , Luo Bin , Wang Bin , Huang Jian
Published: December 2023

On maritime vessels, external factors such as explosions, collisions, and grounding can cause the emulsification of lubricating oil by seawater pollution, which can affect the lubrication of a ship’s thrust bearing. To explore the influence of the mixed emulsification of lubricating oil and seawater on the lubrication performance of thrust bearings, this study conducted an emulsification experiment, from which the viscosity equation of the oil–water mixture was obtained. A thermal hydrodynamic model (THD) of bearings considering oil–water mixed emulsification was established, and the Finite Difference Method (FDM) was used for analysis. The results show that according to the characteristics of the manifold, the mixture is divided into water-in-oil (W/O) and oil-in-water (O/W). In the W/O flow with higher viscosity, the film thickness becomes higher, but the power loss increases. In the O/W manifold with low viscosity, the thin film easily causes mixed friction. In the demulsification stage of the mixed liquid, the thickness loss of the film is huge, and the collision between the thrust-bearing pad and the inference plate may cause the pad to be ablated. The influence of specific heat capacity on temperature is greater than the temperature rise caused by viscosity.
Evaluation of Eruption of Permanent Teeth in Beagle Dog Extraction Sites Filled with Carbonate Apatite
Authors: Kibe Toshiro , Nakazono Kenta , Yamashita Kaoru , Tada Ryohei , Ono Yusuke , Ishihata Kiyohide
Published: December 2023

Autologous bone grafting is the primary method for treating alveolar clefts. However, bone grafting materials are desired as alternatives to autogenous bone to reduce surgical invasiveness. Here, we present an animal study evaluating the effect of carbonate apatite (CA) on the spontaneous eruption of permanent teeth. The bone grafting materials included CA, natural bovine bone (BB), and hydroxyapatite (HA). In 15 8-week-old male beagle dogs, the left mandibular deciduous premolars (DP) two and three were extracted and subsequently filled with CA, BB, and HA. The animals were euthanized after a predetermined number of days, and samples were collected for microcomputed tomography and histological evaluation. Spontaneous eruption of the succeeding permanent teeth (P3 and P4) was observed in the CA group at 14 weeks. Delayed eruption of the succeeding permanent teeth was observed in the BB and HA groups. CA could serve as a viable alternative to autogenous bone for treating alveolar clefts.
Thermal Model and Thermal Analysis of the Dual Drive Sliding Feed System
Authors: Li Hui , Liu Haiyang , Feng Xianying , Liu Yandong , Yao Ming , Wang Anning
Published: December 2023

The dual drive sliding feed system can obtain a uniform and stable resolution at extremely low speeds and significantly reduce the system’s nonlinear friction. However, the numerous thermal sources within the system and the multipoint sliding contact during transmission result in a significant temperature rise, leading to considerable thermal deformation and errors. Moreover, the responsive mechanism of the thermal characteristics needs to be clarified. Therefore, firstly, a frictional torque model of the engagement of the screw and nut is established, and the heat generation, heat transfer, and thermal contact resistance (TCR) are solved. Then, based on the solution, a finite element thermal simulation model of the dual drive sliding feed system is established, and experiments are performed for validation. The results show that the error in temperature at the measuring point is less than 2.1 °C, and the axial thermal elongation of the screw is less than 6.2 µm. Finally, the thermal characteristics of the feeding system under various operating conditions are analyzed. The results show that the established thermal simulated model can effectively describe the dynamic thermal characteristics of the dual drive sliding feed system during operation. The effects of the rotational speed and ambient temperature on the dynamic thermal characteristics of the dual drive sliding feed system are investigated separately. The temperature increase in each part of the screw during the operation is characterized.
Coefficient Bounds for a Certain Subclass of Bi-Univalent Functions Associated with Lucas-Balancing Polynomials
Authors: Hussen Abdulmtalb , Illafe Mohamed
Published: December 2023

In this paper, we introduce a new subclass of bi-univalent functions defined using Lucas-Balancing polynomials. For functions in each of these bi-univalent function subclasses, we derive estimates for the Taylor–Maclaurin coefficients a2 and a3 and address the Fekete–Szegö functional problems for functions belonging to this new subclass. We demonstrate that several new results can be derived by specializing the parameters in our main findings. The results obtained from this study will enrich the theoretical foundation of this field and open new avenues for mathematical inquiry and application.
Research on the Improvement Path of Total Factor Productivity in the Industrial Software Industry: Evidence from Chinese Typical Firms
Authors: Wang Xiaoxiang , Wu Songling , Zhao Lixiang
Published: December 2023

The high-quality development of the industrial software industry is of strategic significance to enhancing the core competitiveness of the manufacturing industry and promoting the high-quality development of China’s industrial economy. By integrating the “capital-technology-environment-human” production factor theory and configuration perspective, this paper constructs a comprehensive analysis framework that drives the total factor productivity (TFP) of the industrial software industry. This paper uses 40 typical industrial software firms in 2018–2020 as case samples and uses fuzzy set Qualitative Comparative Analysis (fsQCA) to empirically explore the influencing factors and complex mechanisms that achieve high-quality development of the industrial software industry. It is found that: (1) a single industrial factor is hardly a necessary condition to drive the industrial software industry; (2) there are four paths to achieving high TFP, which are summarized as “technical-human-environmental” balanced driving type, “capital-human-environmental” balanced driving type, “technical-capital” dual driving type, and “capital” single driving type. There are four driving mechanisms. There are also four not-high TFP configurations with asymmetric characteristics; (3) under certain conditions, the combination of capital factors, technical factors, environmental factors, and human factors can drive TFP in an “all roads lead to Rome”. In this process, the government’s attention plays a more universal role. The study not only expands the application scenarios of fsQCA but also provides decision guidelines for the practice of strategic emerging industrialization represented by the industrial software industry.
Management of Bilateral Diffuse Uveal Melanocytic Proliferation (BDUMP)—A Case Report
Authors: Drača Nataša , Orešković Emma Grace , Lazić Ratimir , Vukojević Marija , Radolović Bertetić Andrea , Vukojević Nenad
Published: December 2023

Background and Objectives: This study reports a case of a 62-year-old patient experiencing a significant decline in vision over the past three months. The initial best-corrected visual acuity (BCVA) of 20/20 in both eyes diminished to 20/200 in the right eye (RE) and counting fingers (CF) in the left eye (LE) within this timeframe. The patient was diagnosed with stage 4 ovarian cancer just one month before the significant vision deterioration. Materials and Methods: A thorough ophthalmologic examination revealed a notable progression of cataracts and the presence of subretinal fluid on the posterior pole, accompanied by choroidal thickening. The right eye exhibited multifocal, orange-pigmented, and elevated choroidal lesions, while the left eye’s fundus examination was impeded by dense cataracts. Optical coherence tomography (OCT) revealed bilateral choroidal thickening with overlying folds and subretinal fluid, and ultrasound imaging of the choroidal lesions indicated moderate homogenous internal reflectivity. Results: The patient received a diagnosis of BDUMP (bilateral diffuse uveal melanocytic proliferation), a paraneoplastic syndrome marked by simultaneous, bilateral, painless vision loss and the rapid onset of bilateral cataracts with serous retinal detachments. Despite cataract extraction, the expected visual recovery was not achieved (RE: CF; LE: 2/200, respectively). Plasmapheresis showed some success in stabilizing vision loss attributed to serous retinal detachments. Conclusions: BDUMP necessitates addressing the underlying malignancy for effective treatment. Left untreated, it can lead to near blindness within a year. The prognosis remains grim, with an average survival time ranging from 12 to 15.7 months from the time of diagnosis. Considering this case report, it is crucial to establish effective management plans and further investigate potential treatment methods and predictive markers centered around BDUMP. Collaboration between healthcare professionals and researchers is crucial in addressing the complexities of BDUMP, as the timely diagnosis and treatment of the disease remains a top priority.
Isolated Deep Infiltrating Endometriosis of the Sciatic Nerve: A Case Report and Overview of the Literature
Authors: Zamurovic Milena , Tomic Ana , Djordjevic Katarina , Simanic Sara , Sopta Jelena , Rasulic Lukas , Simic Ljubica , Jevtic Jovan , Nedeljkovic-Arsenovic Olga , Rovcanin Marija
Published: December 2023

Isolated deep infiltrating endometriosis (DIE) of sacral nerve roots or major pelvic nerves, including the sciatic nerve, is considered to be extremely rare. Due to the overlap with sciatica symptoms, the diagnosis of sciatica DIE is difficult yet crucial, as it results in permanent neural damage if left untreated. We report a case of a 45-year-old woman who experienced a three-year-long and recently exacerbating pain in her right leg, accompanied by a tingling sensation and weakness in her right leg and foot, with difficulty walking. In between regular menstrual bleedings, when her aforementioned symptoms worsened, she had been experiencing mild 10-day extra-cyclical bleeding. Her neurologist’s, orthopedist’s, and gynecological examinations were unremarkable. Magnetic resonance imaging (MRI) showed an infiltrative lesion on the right sciatic nerve that was immunohistochemically confirmed to be endometriosis. The patient was treated with gonadotropin-releasing hormone analogues (GnRHa), which led to a significantly diminished size of the lesion on the control MRI, and endometriosis remission was obtained. For persistent mild, but cyclical, pain and muscle weakness, continuous progestagnes were administered, with advice for physical therapy provided for her neuro-muscle rehabilitation and a scheduled check-up in 6 months.
Review on Bubble Dynamics in Proton Exchange Membrane Water Electrolysis: Towards Optimal Green Hydrogen Yield
Authors: Sangtam Bongliba T. , Park Hanwook
Published: December 2023

Water electrolysis using a proton exchange membrane (PEM) holds substantial promise to produce green hydrogen with zero carbon discharge. Although various techniques are available to produce hydrogen gas, the water electrolysis process tends to be more cost-effective with greater advantages for energy storage devices. However, one of the challenges associated with PEM water electrolysis is the accumulation of gas bubbles, which can impair cell performance and result in lower hydrogen output. Achieving an in-depth knowledge of bubble dynamics during electrolysis is essential for optimal cell performance. This review paper discusses bubble behaviors, measuring techniques, and other aspects of bubble dynamics in PEM water electrolysis. It also examines bubble behavior under different operating conditions, as well as the system geometry. The current review paper will further improve the understanding of bubble dynamics in PEM water electrolysis, facilitating more competent, inexpensive, and feasible green hydrogen production.
Experimental Study of Flow Boiling Regimes Occurring in a Microfluidic T-Junction
Authors: Bao Xiangzhong , Yang Fei , Zhang Xuan
Published: December 2023

Microchannel flow boiling is an efficient cooling method for high-heat-flux electronic devices. To understand the flow boiling regime in a T-shaped microchannel, this paper prepared T-shaped microchannels of different sizes and designed an experimental platform for the visualization of flow boiling in microchannels, and aimed to study the evolution characteristics of two-phase flow patterns in T-shaped microchannels. The influences of the flow rate and channel size on the boiling flow pattern inside a T-shaped microchannel were experimentally observed and quantitatively described. The results indicate that the occurrence position of the vaporization core gradually migrates from branch channel to main channel as the wall temperature increases. The flow boiling at the bifurcation of the T-shaped microchannel mainly includes the extrusion fracture flow, bubble flow, plug–annular alternating flow and annular flow, in which the annular flow can be further divided into the intermittent annular flow and the stable annular flow. In addition, a high flow rate and small channel size can lead to the disappearance of the bubble flow, and the presence of the bubble flow delays the appearance of the annular flow.
Extracellular Vesicles Released by Leishmania (Leishmania) amazonensis Promastigotes with Distinct Virulence Profile Differently Modulate the Macrophage Functions
Authors: Zauli Rogéria Cristina , de Souza Perez Isabelle Carlos , de Morais Aline Correia Costa , Ciaccio Ana Carolina , Vidal Andrey Sladkevicius , Soares Rodrigo Pedro , Torrecilhas Ana Claudia , Batista Wagner Luiz , Xander Patricia
Published: December 2023

Leishmania spp. is the aetiologic agent of leishmaniasis, a disease endemic in several developing countries. The parasite expresses and secretes several virulence factors that subvert the macrophage function and immune response. Extracellular vesicles (EVs) can carry molecules of the parasites that show immunomodulatory effects on macrophage activation and disease progression. In the present work, we detected a significantly higher expression of lpg3 and gp63 genes in Leishmania amazonensis promastigotes recovered after successive experimental infections (IVD-P) compared to those cultured for a long period (LT-P). In addition, we observed a significantly higher percentage of infection and internalized parasites in groups of macrophages infected with IVD-P. Macrophages previously treated with EVs from LT-P showed higher percentages of infection and production of inflammatory cytokines after the parasite challenge compared to the untreated ones. However, macrophages infected with parasites and treated with EVs did not reduce the parasite load. In addition, no synergistic effects were observed in the infected macrophages treated with EVs and reference drugs. In conclusion, parasites cultured for a long period in vitro and recovered from animals’ infections, differently affected the macrophage response. Furthermore, EVs produced by these parasites affected the macrophage response in the early infection of these cells.
Effects of Wood Content and Modification on Properties of Wood Flour/Polybutylene Adipate Terephthalate Biocomposites
Authors: Yu Wangwang , Qiu Rui , Li Mengya , Lei Wen
Published: December 2023

Biodegradable polymers have recently become attractive and have been increasingly used as matrix materials to replace fossil plastics due to concerns about the environmental issue. However, their application areas are limited due to their high costs and natural properties. In this study, we fabricated ecofriendly and economical polybutylene adipate terephthalate (PBAT) composites loaded with various concentrations of wood flour (WF) to investigate the effects on the PBAT and WF interfaces as well as the physical properties of the WF/PBAT biocomposites. Then, WF was acetylated with acetic anhydride, and the effect of WF acetylation on the mechanical and thermal properties of the biocomposites were investigated. The results showed that the tensile strength, tensile modulus, flexural strength and flexural modulus increased with WF loading in the composites, and acetylation could not only further increase these properties, but also increase the impact strength and elongation at break. The incorporation of WF would weaken the thermal stability of PBAT, but the thermal stability of the biocomposite could be improved after WF acetylation. The cold crystallization temperature and hydrophobicity of the WF/PBAT samples would be increased with the increasing load of the WF, while the melting enthalpy and the crystallinity of the samples reduced gradually. A morphological analysis of the modified composites revealed that the matrix exhibited greater interfacial interactions with the WF compared to the WF/PBAT. Considering the much lower cost of WF compared to PBAT, the improved properties of WF/PBAT biocomposites will make it economically competitive with other commercial polymers, and these biocomposites should have much wider application areas.
Assessing the Novel Mixed Tutton Salts K2Mn0.03Ni0.97(SO4)2(H2O)6 and K2Mn0.18Cu0.82(SO4)2(H2O)6 for Thermochemical Heat Storage Applications: An Experimental–Theoretical Study
Authors: de Oliveira Neto João G. , Viana Jailton R. , Lima Antonio D. da S. G. , Lopes Jardel B. O. , Ayala Alejandro P. , Lage Mateus R. , Stoyanov Stanislav R. , dos Santos Adenilson O. , Lang Rossano
Published: December 2023

In this paper, novel mixed Tutton salts with the chemical formulas K2Mn0.03Ni0.97(SO4)2(H2O)6 and K2Mn0.18Cu0.82(SO4)2(H2O)6 were synthesized and studied as compounds for thermochemical heat storage potential. The crystallographic structures of single crystals were determined by X-ray diffraction. Additionally, a comprehensive computational study, based on density functional theory (DFT) calculations and Hirshfeld surface analysis, was performed to calculate structural, electronic, and thermodynamic properties of the coordination complexes [MII(H2O)6]2+ (MII = Mn, Ni, and Cu), as well as to investigate intermolecular interactions and voids in the framework. The axial compressions relative to octahedral coordination geometry observed in the crystal structures were correlated and elucidated using DFT investigations regarding Jahn–Teller effects arising from complexes with different spin multiplicities. The spatial distributions of the frontier molecular orbital and spin densities, as well as energy gaps, provided further insights into the stability of these complexes. Thermogravimetry, differential thermal analysis, and differential scanning calorimetry techniques were also applied to identify the thermal stability and physicochemical properties of the mixed crystals. Values of dehydration enthalpy and storage energy density per volume were also estimated. The two mixed sulfate hydrates reported here have low dehydration temperatures and high energy densities. Both have promising thermal properties for residential heat storage systems, superior to the Tutton salts previously reported.
Investigation of Drug-Interaction Potential for Arthritis Dietary Supplements: Chondroitin Sulfate, Glucosamine, and Methylsulfonylmethane
Authors: Kim Su Min , Jo So Young , Park Ho-Young , Lee Yu Ra , Yu Jun Sang , Yoo Hye Hyun
Published: December 2023

Osteoarthritis is one of the leading conditions that promote the consumption of these dietary supplements. Chondroitin sulfate, glucosamine, and methylsulfonylmethane are among the prominent alternative treatments for osteoarthritis. In this study, these dietary supplements were incubated with cytochrome P450 isozyme-specific substrates in human liver microsomes, and the formation of marker metabolites was measured to investigate their inhibitory potential on cytochrome P450 enzyme activities. The results revealed no significant inhibitory effects on seven CYPs, consistent with established related research data. Therefore, these substances are anticipated to have a low potential for cytochrome P450-mediated drug interactions with osteoarthritis medications that are likely to be co-administered. However, given the previous reports of interaction cases involving glucosamine, caution is advised regarding dietary supplement–drug interactions.
Chia (Salvia hispanica L.), a Pre-Hispanic Food in the Treatment of Diabetes Mellitus: Hypoglycemic, Antioxidant, Anti-Inflammatory, and Inhibitory Properties of α-Glucosidase and α-Amylase, and in the Prevention of Cardiovascular Disease
Authors: Tavera-Hernández Rosario , Jiménez-Estrada Manuel , Alvarado-Sansininea J. Javier , Huerta-Reyes Maira
Published: December 2023

Diabetes mellitus (DM) is considered one of the major health diseases worldwide, one that requires immediate alternatives to allow treatments for DM to be more effective and less costly for patients and also for health-care systems. Recent approaches propose treatments for DM based on that; in addition to focusing on reducing hyperglycemia, they also consider multitargets, as in the case of plants. Among these, we find the plant known as chia to be highlighted, a crop native to Mexico and one cultivated in Mesoamerica from pre-Hispanic times. The present work contributes to the review of the antidiabetic effects of chia for the treatment of DM. The antidiabetic effects of chia are effective in different mechanisms involved in the complex pathogenesis of DM, including hypoglycemic, antioxidant, and anti-inflammatory mechanisms, and the inhibition of the enzymes α-glucosidase and α-amylase, as well as in the prevention of the risk of cardiovascular disease. The tests reviewed included 16 in vivo assays on rodent models, 13 clinical trials, and 4 in vitro tests. Furthermore, chia represents advantages over other natural products due to its availability and its acceptance and, in addition, as a component of the daily diet worldwide, especially due to its omega-3 fatty acids and its high concentration of dietary fiber. Thus, chia in the present work represents a source of antidiabetic agents that would perhaps be useful in novel clinical treatments.
Microfluidic Diffusion Sizing Applied to the Study of Natural Products and Extracts That Modulate the SARS-CoV-2 Spike RBD/ACE2 Interaction
Authors: Fauquet Jason , Carette Julie , Duez Pierre , Zhang Jiuliang , Nachtergael Amandine
Published: December 2023

The interaction between SARS-CoV-2 spike RBD and ACE2 proteins is a crucial step for host cell infection by the virus. Without it, the entire virion entrance mechanism is compromised. The aim of this study was to evaluate the capacity of various natural product classes, including flavonoids, anthraquinones, saponins, ivermectin, chloroquine, and erythromycin, to modulate this interaction. To accomplish this, we applied a recently developed a microfluidic diffusional sizing (MDS) technique that allows us to probe protein-protein interactions via measurements of the hydrodynamic radius (Rh) and dissociation constant (KD); the evolution of Rh is monitored in the presence of increasing concentrations of the partner protein (ACE2); and the KD is determined through a binding curve experimental design. In a second time, with the protein partners present in equimolar amounts, the Rh of the protein complex was measured in the presence of different natural products. Five of the nine natural products/extracts tested were found to modulate the formation of the protein complex. A methanol extract of Chenopodium quinoa Willd bitter seed husks (50 µg/mL; bisdesmoside saponins) and the flavonoid naringenin (1 µM) were particularly effective. This rapid selection of effective modulators will allow us to better understand agents that may prevent SARS-CoV-2 infection.
Synthesis and Structures of Lead(II) Complexes with Substituted Derivatives of the Closo-Decaborate Anion with a Pendant N3 Group
Authors: Matveev Evgenii Yu. , Dontsova Olga S. , Avdeeva Varvara V. , Kubasov Alexey S. , Zhdanov Andrey P. , Nikiforova Svetlana E. , Goeva Lyudmila V. , Zhizhin Konstantin Yu. , Malinina Elena A. , Kuznetsov Nikolay T.
Published: December 2023

In this work, we studied lead(II) and cobalt(II) complexation of derivatives [2-B10H9O(CH2)2O(CH2)2N3]2− and [2-B10H9O(CH2)5N3]2− of the closo-decaborate anion containing pendant azido groups in the presence of 1,10-phenanthroline and 2,2′-bipyridyl. Mononuclear [PbL2{An}] and binuclear [Pb2L4(NO3)2{An}] lead complexes (where {An} is the N3-substituted boron cluster) were isolated and studied by IR spectroscopy and elemental analysis. The mononuclear lead(II) complex [Pb(phen)2[B10H9O(CH2)2O(CH2)2N3] and the binuclear lead(II) complex [Pb2(phen)4(NO3)2[B10H9O(CH2)5)N3] were determined by single-crystal X-ray diffraction. In complex [Pb2(phen)4(NO3)2[B10H9O(CH2)5)N3], the boron cluster is coordinated by the metal atom only via the 3c2e MHB bonds. In complex [Pb(phen)2[B10H9O(CH2)2O(CH2)2N3], the coordination environment of the metal includes BH groups of the boron cluster and the oxygen atom of the exo-polyhedral substituent. When the reaction was performed in a CH3CN/water mixture, the binuclear lead(II) complex [(Pb(bipy)NO3)(Pb(bipy)2NO3)(B10H9O(CH2)2O(CH2)2N3)]·CH3CN·H2O was isolated, where the boron cluster acts as a bridging ligand between lead atoms coordinated by the boron cage via the O atoms of the substituent and/or the BH groups. In the course of cobalt(II) complexation, the starting compound (Ph4P)2[B10H9O(CH2)5N3] was isolated and its structure was also determined by X-ray diffraction. Although a number of lead(II) complexes with coordinated N3 are known from the literature, no complexes with the boron cluster coordinated by the pendant N3 group involved in the metal coordination have been isolated.
Effects of Sous-Vide on Quality, Structure and Flavor Characteristics of Tilapia Fillets
Authors: Yang Luqian , Li Zhaoyong , Xie Tianxiang , Feng Jun , Xu Xinxing , Zhao Yuanhui , Gao Xin
Published: December 2023

To investigate the effects of traditional high-temperature cooking and sous-vide cooking on the quality of tilapia fillets, muscle microstructure, texture, lipid oxidation, protein structure, and volatile compounds were analyzed. In comparison with samples subjected to traditional high-temperature cooking, sous-vide-treated samples exhibited less protein denaturation, a secondary structure dominated by α-helices, a stable and compact structure, a significantly higher moisture content, and fewer gaps in muscle fibers. The hardness of the sous-vide-treated samples was higher than that of control samples, and the extent of lipid oxidation was significantly reduced. The sous-vide cooking technique resulted in notable changes in the composition and relative content of volatile compounds, notably leading to an increase in the presence of 1-octen-3-ol, α-pinene, and dimethyl sulfide, and a decrease in the levels of hexanal, D-limonene, and methanethiol. Sous-vide treatment significantly enhanced the structural stability, hardness, and springiness of muscle fibers in tilapia fillets and reduced nutrient loss, enriched flavor, and mitigated effects on taste and fishy odor.
Paeoniflorin Induces ER Stress-Mediated Apoptotic Cell Death by Generating Nox4-Derived ROS under Radiation in Gastric Cancer
Authors: Kim Tae Woo
Published: December 2023

Gastric cancer is one of the most prevalent cancer types worldwide, and its resistance to cancer therapies, such as chemotherapy and radiotherapy, has made treating it a major challenge. Paeoniflorin (PF) is one potential pharmacological treatment derived from paeony root. However, in cancer, the molecular mechanisms and biological functions of PF are still unclear. In the present study, we found that PF exerts anti-tumor effects in vivo and in vitro and induces apoptotic cell death through ER stress, calcium (Ca2+), and reactive oxygen species (ROS) release in gastric cancer cells. However, ROS inhibition by DPI and NAC blocks cell death and the PERK signaling pathway via the reduction of Nox4. Moreover, PF triggers a synergistic inhibitory effect of the epithelial-mesenchymal transition (EMT) process under radiation exposure in radiation-resistant gastric cancer cells. These findings indicate that PF-induced Ca2+ and ROS release overcomes radioresistance via ER stress and induces cell death under radiation in gastric cancer cells. Therefore, PF, in combination with radiation, may be a powerful strategy for gastric cancer therapy.
Optimization of a Food List for Food Frequency Questionnaires Using Mixed Integer Linear Programming: A Proof of Concept Based on Data from the Second German National Nutrition Survey
Authors: Blaurock Julia , Heuer Thorsten , Gedrich Kurt
Published: December 2023

Food Frequency Questionnaires (FFQs) are important instruments to assess dietary intake in large epidemiological studies. To determine dietary intake correctly, food lists need to be adapted depending on the study aim and the target population. The present work compiles food lists for an FFQ with Mixed Integer Linear Programming (MILP) to minimize the number of foods in the food list. The optimized food lists were compared with the validated eNutri FFQ. The constraints of the MILP aimed to identify food items with a high nutrient coverage in a population and with a high interindividual variability. The optimization was based on data from the second German National Nutrition Survey. The resulting food lists were shorter than the one used in the validated eNutri FFQ.
Sleep, Nutrition, and Injury Risk in Adolescent Athletes: A Narrative Review
Authors: Mason Lorcán , Connolly James , Devenney Lydia E. , Lacey Karl , O’Donovan Jim , Doherty Rónán
Published: December 2023

This narrative review explores the impact of sleep and nutrition on injury risk in adolescent athletes. Sleep is viewed as essential to the recuperation process and is distinguished as an active participant in recovery through its involvement in growth, repair, regeneration, and immunity. Furthermore, the literature has shown that the sleep of athletes impacts elements of athletic performance including both physical and cognitive performance, recovery, injury risk, and mental well-being. For sleep to have a restorative effect on the body, it must meet an individual’s sleep needs whilst also lasting for an adequate duration and being of adequate quality, which is age-dependent. The literature has suggested that athletes have increased sleep needs compared to those of the general population and thus the standard recommendations may not be sufficient for athletic populations. Therefore, a more individualised approach accounting for overall sleep health may be more appropriate for addressing sleep needs in individuals including athletes. The literature has demonstrated that adolescent athletes achieve, on average, ~6.3 h of sleep, demonstrating a discrepancy between sleep recommendations (8–10 h) and actual sleep achieved. Sleep–wake cycles undergo development during adolescence whereby adaptation occurs in sleep regulation during this phase. These adaptations increase sleep pressure tolerance and are driven by the maturation of physiological, psychological, and cognitive functioning along with delays in circadian rhythmicity, thus creating an environment for inadequate sleep during adolescence. As such, the adolescent period is a phase of rapid growth and maturation that presents multiple challenges to both sleep and nutrition; consequently, this places a significant burden on an adolescent athletes’ ability to recover, thus increasing the likelihood of injury. Therefore, this article aims to provide a comprehensive review of the available literature on the importance of sleep and nutrition interactions in injury risk in adolescent athletes. Furthermore, it provides foundations for informing further investigations exploring the relation of sleep and nutrition interactions to recovery during adolescence.
Nutritional Status, Intentions and Motivations towards Adopting a Planetary Health Diet—A Cross-Sectional Study
Authors: Ambroży Urszula , Błaszczyk-Bębenek Ewa , Ambroży Dorota , Jagielski Paweł , Rydzik Łukasz , Ambroży Tadeusz
Published: December 2023

The planetary health diet is a proposition of a diet that is healthy for both people and the environment. The aim of this study was to investigate the nutritional behaviours among people who follow the planetary health diet and those who do not and assess the source of motivation that drives a willingness to follow sustainable diet guidelines. Using a self-administered questionnaire, data were collected from Polish adult volunteers. For analysis, respondents were divided into the following two groups: those following a planetary health diet (PD) and those who were not (O). Of the 216 respondents, 39.4% followed the PD. Non-adherence to the PD was linked to a higher prevalence of overweight and obesity. Taste was the most important factor for both groups during grocery shopping. However, sustainable agriculture and the health benefits of products were significantly more important for the PD followers. It can be concluded that adherence to the planetary diet is associated with lower body mass. This highlights the need for increased awareness and education about a diet’s health benefits and environmental impact.
Special Issue on Photonic State Tomography: Methods and Applications
Authors: Czerwinski Artur
Published: December 2023

The realm of quantum engineering has undergone a remarkable transformation in recent years [...]
Reinforcement Learning Environment for Wavefront Sensorless Adaptive Optics in Single-Mode Fiber Coupled Optical Satellite Communications Downlinks
Authors: Parvizi Payam , Zou Runnan , Bellinger Colin , Cheriton Ross , Spinello Davide
Published: December 2023

Optical satellite communications (OSC) downlinks can support much higher bandwidths than radio-frequency channels. However, atmospheric turbulence degrades the optical beam wavefront, leading to reduced data transfer rates. In this study, we propose using reinforcement learning (RL) as a lower-cost alternative to standard wavefront sensor-based solutions. We estimate that RL has the potential to reduce system latency, while lowering system costs by omitting the wavefront sensor and low-latency wavefront processing electronics. This is achieved by adopting a control policy learned through interactions with a cost-effective and ultra-fast readout of a low-dimensional photodetector array, rather than relying on a wavefront phase profiling camera. However, RL-based wavefront sensorless adaptive optics (AO) for OSC downlinks faces challenges relating to prediction latency, sample efficiency, and adaptability. To gain a deeper insight into these challenges, we have developed and shared the first OSC downlink RL environment and evaluated a diverse set of deep RL algorithms in the environment. Our results indicate that the Proximal Policy Optimization (PPO) algorithm outperforms the Soft Actor–Critic (SAC) and Deep Deterministic Policy Gradient (DDPG) algorithms. Moreover, PPO converges to within 86% of the maximum performance achievable by the predominant Shack–Hartmann wavefront sensor-based AO system. Our findings indicate the potential of RL in replacing wavefront sensor-based AO while reducing the cost of OSC downlinks.
Fibrillar Hydrogel Based on Cellulose Nanocrystals Crosslinked via Diels–Alder Reaction: Preparation and pH-Sensitive Release of Benzocaine
Authors: Morozova Sofia M. , Korzhikova-Vlakh Evgenia G.
Published: December 2023

A fibrillar hydrogel was obtained by covalent crosslinking via Diels–Alder reaction of two types of cellulose nanocrystals (CNCs) with furan and maleimide groups. Gelation has been studied at various ratios of components and temperatures in the range from 20 to 60 °C. It was shown that the rheological properties of the hydrogel can be optimized by varying the concentration and ratio of components. Due to the rigid structure of the CNCs, the hydrogel could be formed at a concentration of at least 5 wt%; however, it almost does not swell either in water with pH 5 or 7 or in the HBSS buffer. The introduction of aldehyde groups into the CNCs allows for the conjugation of physiologically active molecules containing primary amino groups due to the formation of imine bonds. Here, we used benzocaine as a model drug for conjugation with CNC hydrogel. The resulting drug-conjugated hydrogel demonstrated the stability of formulation at pH 7 and a pH-sensitive release of benzocaine due to the accelerated hydrolytic cleavage of the imine bond at pH < 7. The developed drug-conjugated hydrogel is promising as wound dressings for local anesthesia.
Automated Quantification of Interlaminar Delaminations in Carbon-Fiber-Reinforced Polymers via High-Resolution Ultrasonic Testing
Authors: Matalgah Khaled , Ravindranath Pruthul Kokkada , Pulipati Daniel , Fleck Trevor J.
Published: December 2023

This article presents a method of ultrasonic testing (UT) that detects and quantifies interlaminar delaminations in CFRP composites with high resolution in terms of both spatial resolution in the planar dimension and depth into the laminate. Unidirectional and woven CFRP laminates were fabricated for this study, with a PTFE film inserted at various depths throughout the laminate to act as intentional crack initiation sites. All samples were mechanically tested via a three-point, end-notched flexure (ENF) test, followed by a quantification of the extent of the induced interlaminar delaminations using UT and X-ray computed tomography (CT). UT analysis for unidirectional CFRP samples was able to show a clear contrast between the delaminated area and the non-delaminated area. UT analysis of the woven CFRP samples yielded comparable results but required finer tuning of analysis parameters due to the interlocking woven fabric. CT results revealed a significant contrast between the crack and composite; thus, fine geometrical features of the crack front could be observed. UT and CT measurements were then compared, revealing an average difference of 1.09% in the delamination area, with UT overestimating as compared to CT. A UT depth study was also performed to automatically locate the interlaminar delamination at different depths throughout the components, with the delamination being predicted within one lamina interface for all samples. These results demonstrate UT’s ability to accurately detect and quantify the extent and location of interlaminar delaminations due to bending.
Polyolefin Blends with Selectively Crosslinked Disperse Phase Based on Silane-Modified Polyethylene
Authors: Gahleitner Markus , Pham Tung , Machl Doris
Published: December 2023

Polypropylene-based multiphase compositions with a disperse elastomer phase provide superior impact strength. Making this property indifferent to processing steps requires stabilization of the morphology of these materials. Various approaches have been tested over time, each of which shows limitations in terms of performance or applicability. Using polyethylene (PE) homo- and copolymers capable of silane-based crosslinking as modifiers was explored in the present study, which allows decoupling of the mixing and crosslinking processes. Commercial silane-copolymerized low-density PE (LD-PEX) from a high-pressure process and silane-grafted high-density PE (HD-PEX) were studied as impact modifiers for different types of PP copolymers, including non-modified reference PE grades, LDPE and HDPE. Blends based on ethylene–propylene random copolymers (PPR) and based on impact- (PPI) and random-impact (PPRI) copolymers show improvements of the stiffness–impact balance; however, to different degrees. While the absolute softest and most ductile compositions are achieved with the already soft PPRI copolymer base, the strongest relative effects are found for the PPR based blends. Modifiers with lower density are clearly superior in the toughening effect, with the LD-PEX including acrylate as second comonomer sticking out due to its glass transition around −40 °C. The impact strength improvement found in most compositions (except at very high content) results, however, not from the expected phase stabilization. For comparable systems, particle sizes are normally higher with crosslinking, probably because the process already starts during mixing. Thermoplastic processability could be retained in all cases, but the drop in melt flow rate limits the practical applicability of such systems.
Using Standstill Time to Evaluate the Startup in Polymer Pair Systems
Authors: Ptak Anita , Łuksza Zuzanna
Published: December 2023

The subject of polymer–polymer pair interaction is highly important, bearing in mind that such pairs are used in the construction of machines and equipment, among other uses. Considering that the characteristics of polymer–polymer sliding pairs (e.g., the load limit value and advantageous parameter, PV) differ from those of polymer–metal pairs, the subject is particularly interesting and has been little explored so far. Hence, the present study presents one of the areas of the effects of standstill time (intrinsically characteristic of polymeric materials) on the startup parameters in sliding pairs where the sample and the countersample were made of a polymeric material. Pairs of same-type polymers, POM–POM, PET–PET, and PA6–PA6, were subjected to tests. A test rig dedicated to static friction coefficient determination, whose principle of operation is based on the interdependences between the force characteristics of an inclined plane, was used for this purpose. The sliding pair was successively loaded with 25 N, 50 N, and 75 N, and the standstill time ranged from 0 to 10 min. The determined tribological characteristics were analysed with regard to the standstill time under load, unit pressure, and polymer pair material. An optical profilometer and a scanning electron microscope were used to qualitatively evaluate the effects of standstill time and unit pressure on the surfaces of the interacting elements. Complex interrelationships between the test results and the set experimental parameters were noted. SEM micrographs revealed post-friction changes in the sliding surfaces.
Characterization of Failure Behavior in Unidirectional Fiber-Reinforced Polymer via Off-Axis Compression on Small Block Specimens
Authors: Yang Fan , Li Yazhi , Li Biao
Published: December 2023

An experimental investigation was focused on the failure behavior of unidirectional fiber-reinforced polymers when subjected to combined longitudinal/transverse compression and in-plane shear due to off-axis loading. Block-shaped and end-loaded specimens, spanning ten different fiber orientations (0°, 5°, 10°, 15°, 20°, 30°, 45°, 60°, 75°, and 90° with respect to the loading direction), were loaded to ultimate failure using a dedicated fixture. Different failure modes, including longitudinal compression, in-plane shear, and transverse compression, were identified, along with distinctive characteristics of the corresponding failure envelopes. Four physically based failure theories—Hashin, Camanho, Puck, and LaRC05—were subjected to a comparative analysis. Criteria derived from the concept of the action plane consistently outperformed in describing matrix-dominated failures, providing both qualitative and quantitative predictions of failure stresses and fracture plane orientation. However, for fiber-dominated failures, these theories seem to fall short in providing satisfactory predictions, particularly in accurately describing the influence of shear on fiber compression failure. Although criteria based on fiber-kinking theory can reasonably explain the formation of kink bands, they tend to yield overly conservative results. Recalibrations and minor refinement based on experimental results were implemented, leading to an improved agreement. Finally, the constructive role of off-axis compression tests in characterizing the failure behavior of unidirectional composites is discussed.