bluuebunny/crossref_metadata_2025 huggingface dataset:
Más allá de la evaluación de las competencias del psicólogo colombiano: necesidad de un modelo de formación básico y común a nivel nacional
Authors: Torres Germán
Published: March 2020

La presente investigación está relacionada con la enseñanza de la psicología en Colombia, y tiene como objetivo caracterizar las competencias de los psicólogos que definen los principales modelos nacionales e internacionales, para analizarlas y plantear un modelo de formación por competencias del psicólogo colombiano. El método utilizado fue la revisión y análisis de documentos de cada modelo a partir de: la definición del concepto de competencia, el tipo de competencias definido, las estrategias de formación y evaluación de las competencias, y las áreas curriculares asociadas con las competencias. Como conclusión, se estableció que la mayoría de modelos definen las competencias desde una perspectiva profesional centrada en los servicios psicológicos al usuario, pero ésta no se relaciona directamente con el proyecto de vida de los psicólogos, por lo que se propone un modelo de formación por competencias que responda a esta necesidad.
Amor, sexualidad e inicio de nuevas relaciones en la vejez: percepción de tres grupos etarios
Authors: Cerquera Córdoba Ara Mercedes , Galvis Aparicio Mayra Juliana , Cala Rueda María Lucía
Published: March 2020

La sexualidad suele ser un tema tabú, más si se habla de esta en la vejez, pues se considera que las personas mayores no son aptas para vivirla y mucho menos para disfrutarla tal como una persona joven. Por esto, a partir de dos reactivos extraídos del cuestionario Actitudes hacia la sexualidad en la vejez desarrollado por Orozco y Rodríguez en el año 2006 y adaptado al contexto de Floridablanca, se busca conocer por medio de diseño no experimental de corte transversal descriptivo las percepciones de107 adolescentes, 68 adultos y153 personas mayores, sobre el derecho de estos últimos al amor, la vida sexual y que una persona mayor que haya enviudado establezca nuevamente una relación afectiva. Ante estos mitos se obtuvieron respuestas positivas en las tres poblaciones, la mayoría de los participantes afirman estar de acuerdo con los reactivos. El grupo etario con la percepción más negativa aunque en un pequeño porcentaje para cada ítem estudiado (15,9% y 20,6% para el primero y segundo respectivamente), fue el de los adolescentes. En conclusion, el amor y la sexualidad continúan siendo aspectos de gran importancia en la vida del ser humano, aún en etapas avanzadas del ciclo vital. Sin embargo, cada grupo generacional tiene sus propias percepciones respecto a la misma, las cuales pueden limitar o favorecer su expresión y disfrute aún en la vejez.
Spatial interpolation of rain-field dynamic time-space evolution based on radar rainfall data
Authors: Liu Peng , Tung Yeou-Koung
Published: March 2020

Accurate and reliable measurement and prediction of the spatial and temporal distribution of rain field over a wide range of scales are important topics in hydrologic investigations. In this study, a geostatistical approach was adopted. To estimate the rainfall intensity over a study domain with the sample values and the spatial structure from the radar data, the cumulative distribution functions (CDFs) at all unsampled locations were estimated. Indicator kriging (IK) was used to estimate the exceedance probabilities for different preselected threshold levels, and a procedure was implemented for interpolating CDF values between the thresholds that were derived from the IK. Different probability distribution functions of the CDF were tested and their influences on the performance were also investigated. The performance measures and visual comparison between the observed rain field and the IK-based estimation suggested that the proposed method can provide good results of the estimation of indicator variables and is capable of producing a realistic image.
Molecular-level comparison of dissolved organic matter in 11 major lakes in Japan by Orbitrap mass spectrometry
Authors: Kasuga Ikuro , Yuthawong Vitharuch , Kurisu Futoshi , Furumai Hiroaki
Published: March 2020

Dissolved organic matter (DOM) causes organic pollution in lakes, resulting in the occurrence of off-flavour etc. when lake water is used as a drinking water source. In this study, DOM in 11 major lakes in Japan was characterised by high-resolution Orbitrap mass spectrometry. Molecular formulas were assigned to 845–1,451 components per sample. Among them, 555 components were commonly found in all lakes. The DOM compositions of the 11 lakes were clustered into four groups. Correlation analysis could extract specific components whose relative intensities were associated with water quality indices such as specific ultraviolet absorbance, specific dissolved chemical oxygen demand (DCODMn), and specific trihalomethane formation potential (R = 0.80–0.93, p < 0.05). Although further molecular structural analyses of DOM components are necessary, these results could be informative for exploring key candidates related to specific water quality issues. Pre-treatment of samples with permanganate oxidation was applied to screen components which could contribute to DCODMn. DCODMn components accounted for only 7–30% of total peak intensities, indicating the limited performance of permanganate oxidation. Pre-treatment by permanganate coupled with Orbitrap MS revealed that components with higher molecular weight, higher oxygen-to-carbon ratios (O/C), and lower hydrogen-to-carbon ratios (H/C) could be responsible for DCODMn.
Setting New Routes for Antifungal Drug Discovery Against Pathogenic Fungi
Authors: Freitas e Silva Kleber S. , C. Silva Lívia , Gonçales Relber A. , Neves Bruno J. , Soares Célia M.A. , Pereira Maristela
Published: March 2020

:

Fungal diseases are life-threatening to human health and responsible for millions of deaths around the world. Fungal pathogens lead to a high number of morbidity and mortality. Current antifungal treatment comprises drugs, such as azoles, echinocandins, and polyenes and the cure is not guaranteed. In addition, such drugs are related to severe side effects and the treatment lasts for an extended period. Thus, setting new routes for the discovery of effective and safe antifungal drugs should be a priority within the health care system. The discovery of alternative and efficient antifungal drugs showing fewer side effects is time-consuming and remains a challenge. Natural products can be a source of antifungals and used in combinatorial therapy. The most important natural products are antifungal peptides, antifungal lectins, antifungal plants, and fungi secondary metabolites. Several proteins, enzymes, and metabolic pathways could be targets for the discovery of efficient inhibitor compounds and recently, heat shock proteins, calcineurin, salinomycin, the trehalose biosynthetic pathway, and the glyoxylate cycle have been investigated in several fungal species. HSP protein inhibitors and echinocandins have been shown to have a fungicidal effect against azole-resistant fungi strains. Transcriptomic and proteomic approaches have advanced antifungal drug discovery and pointed to new important specific-pathogen targets. Certain enzymes, such as those from the glyoxylate cycle, have been a target of antifungal compounds in several fungi species. Natural and synthetic compounds inhibited the activity of such enzymes and reduced the ability of fungal cells to transit from mycelium to yeast, proving to be promisor antifungal agents. Finally, computational biology has developed effective approaches, setting new routes for early antifungal drug discovery since normal approaches take several years from discovery to clinical use. Thus, the development of new antifungal strategies might reduce the therapeutic time and increase the quality of life of patients.
Syngonanthus nitens (Bong.) Ruhland Derivatives Loaded into a Lipid Nanoemulsion for Enhanced Antifungal Activity Against Candida parapsilosis
Authors: C. de Lima Laura , A.S. Ramos Matheus , Toledo Luciani G. de , Rodero Camila F. , Hilário Felipe , dos Santos Lourdes C. , Chorilli Marlus , Bauab Taís M.
Published: March 2020

Background:

Vaginal infections caused by non-albicans species have become common in women of
all age groups. The resistance of species such as Candida parapsilosis to the various antifungal agents is a risk
factor attributed to these types of infections, which instigates the search for new sources of active compounds in
vulvovaginal candidiasis (VCC) therapy.

Objective:

This study evaluated the antifungal activity of Syngonanthus nitens Bong. (Ruhland) derivatives and
employed a lipid nanoemulsion as a delivery system.

Methods:

In this study, a lipid nanoemulsion was employed as a delivery system composed of Cholesterol (10%),
soybean phosphatidylcholine: Brij 58 (1: 2) and PBS (pH 7.4) with the addition of 0.5% of a chitosan dispersion
(80%), and evaluated the antifungal activity of S. nitens Bong. (Ruhland) derivatives against planktonic cells and
biofilms of Candida parapsilosis. By a biomonitoring fractionation, the crude extract (EXT) and one fraction (F2)
were selected and incorporated into a lipid nanoemulsion (NL) composed of cholesterol (10%), a 1:2 mixture of
soybean phosphatidylcholine:polyoxyethylene -20- cetyl ether (10%), and phosphate buffer solution (pH 7.4)
with a 0.5% chitosan dispersion (80%). The NL presented a diameter size between 50-200 nm, pseudoplastic
behavior, and positive charge. The EXT and five fractions were active against planktonic cells.

Results and Discussion:

The incorporation of EXT and F2 into the NL increased antifungal activity and enhanced
the anti-biofilm potential. This study classified the use of an NL as an important tool for the administration
of S. nitens derivatives in cases of infections caused by this C. parapsisilosis.

Conclusion:

This work concluded that S. nitens derivatives were important sources of active molecules against C.
parapsilosis and the use of a lipid nanoemulsion was an important tool to promote more effective F2 release and
to improve the antifungal activity aiming the control of C. parapsilosis infections.
Treatment of Severe Aplastic Anemia with Porcine Anti-Human Lymphocyte Globulin
Authors: Lv Qi , Huiqin Zhang , Na Xiao , Chunyan Liu , Zonghong Shao , Huaquan Wang
Published: March 2020

Aplastic anemia (AA) is a bone marrow failure syndrome characterized by pancytopenia. Decreased
numbers of hematopoietic stem cells and impaired bone marrow microenvironment caused by abnormal immune
function describe the major pathogenesis of AA. Hematopoietic stem cell transplantation and immunesuppressive
therapy are the first-line treatments for AA. Porcine anti-lymphocyte globulin (p-ALG) is a new
product developed in China. Several studies have shown that p-ALG exhibited good therapeutic effects in AA.
Vaccinium myrtillus L. Fruits as a Novel Source of Phenolic Compounds with Health Benefits and Industrial Applications - A Review
Authors: Pires Tânia C. S. P. , Caleja Cristina , Santos-Buelga Celestino , Barros Lillian , Ferreira Isabel C.F.R.
Published: March 2020

:

Consumers’ demand for healthier foods with functional properties has had a clear influence on the food
industry and in this sense, they have been attaching natural sources of bioactive ingredients into food products.
Vaccinium myrtillus L. (bilberry) is known to be a functional food, presenting its fruits in the form of a small dark
blueberry. This coloration is due to its high content in anthocyanin, being also associated with bilberries’ beneficial
health effects. In the bilberry industry, there is a very high annual loss of this fruit due to the less aesthetic
shape or appearance, in which they cannot be considered suitable for sale and are therefore disposed of as biological
waste. Therefore, it is of great importance to valorize this fruit and this review aimed to completely characterize
the fruits of V. myrtillus in order to comprehend the relationship between their consumption and the beneficial
effects regarding consumer’s health. Thus, this review provides a description of the nutritional and bioactive
compounds present in bilberry fruits, followed by their beneficial health effects. An overview of the natural pigments
present in these fruits was also explored, focusing particularly in the anthocyanins composition, which
represents the most widely studied class of bioactive compounds of V. myrtillus fruits. Finally, industrial applications
of these fruits and by-products, as an efficient approach to the production of value-added products with
economical and environmental impact, were also discussed.

:

In general, V. myrtillus is a rich source of micronutrients and phytochemical compounds, such as organic acids,
sugars, vitamins, fibers and phenolic compounds (anthocyanin and non-anthocyanin compounds), with nutritional
and functional properties, that justify the growing interest in these berries, not only for food applications, but also
in the pharmaceutical industry.
Therapeutic Nanoemulsion: Concept to Delivery
Authors: Barkat Md. A. , Harshita  , Rizwanullah Md. , Pottoo Faheem H. , Beg Sarwar , Akhter Sohail , Ahmad Farhan J.
Published: March 2020

:

Nanoemulsions (NEs) or nanometric-scaled emulsions are transparent or translucent, optically isotropic and kinetically stable heterogeneous system of two different immiscible liquids namely, water and oil stabilized with an amphiphilic surfactant having droplet size ranges up to 100 nm. They offer a variety of potential interests for certain applications: improved deep-rooted stability; excellent optical clarity; and, enhanced bioavailability due to its nanoscale of particles. Though there is still comparatively narrow insight apropos design, development, and optimization of NEs, which mainly stems from the fact that conventional characteristics of emulsion development and stabilization only partly apply to NEs. The contemporary article focuses on the nanoemulsion dosage form journey from concept to key application in drug delivery. In addition, industrial scalability of the nanoemulsion, as well as its presence in commercial and clinical practice, are also addressed.
Treatment of Anderson-Fabry Disease
Authors: Simonetta Irene , Tuttolomondo Antonino , Daidone Mario , Miceli Salvatore , Pinto Antonio
Published: March 2020

Fabry disease is an X-linked disorder of glycosphingolipid metabolism that results in progressive accumulation
of neutral glycosphingolipids, predominantly globotriaosylsphingosine (Gb3) in lysosomes, as well as
other cellular compartments of several tissues, causing multi-organ manifestations (acroparesthesias, hypohidrosis,
angiokeratomas, signs and symptoms of cardiac, renal, cerebrovascular involvement). Pathogenic mutations
lead to a deficiency of the lysosomal enzyme alpha-galactosidase A (GLA). In the presence of high clinical suspicion,
a careful physical examination and specific laboratory tests are required. Finally, the diagnosis of Fabry’s
disease is confirmed by the demonstration of the absence of or reduced alpha-galactosidase A enzyme activity in
hemizygous men and gene typing in heterozygous females. Measurement of the biomarkers Gb3 and Lyso Gb3 in
biological specimens may facilitate diagnosis. The current treatment of Anderson-Fabry disease is represented by
enzyme replacement therapy (ERT) and oral pharmacological chaperone. Future treatments are based on new
strategic approaches such as stem cell-based therapy, pharmacological approaches chaperones, mRNA therapy,
and viral gene therapy.

This review outlines the current therapeutic approaches and emerging treatment strategies for Anderson-Fabry
disease.
Formulation of Extended-Release Beads of Lamotrigine Based on Alginate and Cassia fistula Seed Gum by QbD Approach
Authors: Jain Dixita , Sodani Akshay , Ray Swapnanil , Ghosh Pranab , Nandi Gouranga
Published: March 2020

Aim:

This study was focused on the formulation of the multi-unit extended-release peroral
delivery device of lamotrigine for better management of epilepsy.

Background:

The single-unit extended-release peroral preparations often suffer from all-or-none effect.
A significant number of multi-unit delivery systems have been reported as a solution to this problem.
But most of them are found to be composed of synthetic, semi-synthetic or their combination having
physiological toxicity as well as negative environmental impact. Therefore, fabrication and formulation
of multi-unit extended-release peroral preparations with natural, non-toxic, biodegradable polymers employing
green manufacturing processes are being appreciated worldwide.

Objective:

Lamotrigine-loaded extended-release multi-unit beads have been fabricated with the incorporation
of a natural polysaccharide Cassia fistula seed gum in calcium-cross-linked alginate matrix employing
a simple green process and 23 full factorial design.

Methods:

The total polymer concentration, polymer ratio and [CaCl2] were considered as independent
formulation variables with two different levels of each for the experiment-design. The extended-release
beads were then prepared by the ionotropic gelation method using calcium chloride as the crosslinkerions
provider. The beads were then evaluated for drug encapsulation efficiency and drug release. ANOVA
of all the dependent variables such as DEE, cumulative % drug release at 2h, 5h, 12h, rate constant
and dissolution similarity factor (f2) was done by 23 full factorial design using Design-Expert software
along with numerical optimization of the independent variables in order to meet USP-reference release
profile.

Results:

The optimized batch showed excellent outcomes with DEE of 84.7 ± 2.7 (%), CPR2h of 8.41±
2.96 (%), CPR5h of 36.8± 4.7 (%), CPR12h of 87.3 ± 3.64 (%) and f2 of 65.9.

Conclusion:

This approach of the development of multi-unit oral devices utilizing natural polysaccharides
might be inspiring towards the world-wide effort for green manufacturing of sustained-release drug
products by the QbD route.
Dehydroepiandrosterone (DHEA) and its Sulphate (DHEAS) in Alzheimer’s Disease
Authors: Strac Dubravka S. , Konjevod Marcela , Perkovic Matea N. , Tudor Lucija , Erjavec Gordana N. , Pivac Nela
Published: March 2020

Background:

Neurosteroids Dehydroepiandrosterone (DHEA) and Dehydroepiandrosterone Sulphate (DHEAS) are involved in many important brain functions, including neuronal plasticity and survival, cognition and behavior, demonstrating preventive and therapeutic potential in different neuropsychiatric and neurodegenerative disorders, including Alzheimer’s disease.

Objective:

The aim of the article was to provide a comprehensive overview of the literature on the involvement of DHEA and DHEAS in Alzheimer’s disease.

Method:

PubMed and MEDLINE databases were searched for relevant literature. The articles were selected considering their titles and abstracts. In the selected full texts, lists of references were searched manually for additional articles.

Results:

We performed a systematic review of the studies investigating the role of DHEA and DHEAS in various in vitro and animal models, as well as in patients with Alzheimer’s disease, and provided a comprehensive discussion on their potential preventive and therapeutic applications.

Conclusion:

Despite mixed results, the findings of various preclinical studies are generally supportive of the involvement of DHEA and DHEAS in the pathophysiology of Alzheimer’s disease, showing some promise for potential benefits of these neurosteroids in the prevention and treatment. However, so far small clinical trials brought little evidence to support their therapy in AD. Therefore, large-scale human studies are needed to elucidate the specific effects of DHEA and DHEAS and their mechanisms of action, prior to their applications in clinical practice.
Joint Effect of ABCA7 rs4147929 and Body Mass Index on Progression from Mild Cognitive Impairment to Alzheimer’s Disease: The Shanghai Aging Study
Authors: Xi Jianxiong , Ding Ding , Zhao Qianhua , Liang Xiaoniu , Zheng Li , Guo Qihao , Hong Zhen , Fu Hua , Xu Jianfeng , Xiao Qianyi
Published: March 2020

Background:

Approximately 40 independent Single Nucleotide Polymorphisms (SNPs) have
been associated with Alzheimer’s Disease (AD) or cognitive decline in genome-wide association studies.

Methods:

We aimed to evaluate the joint effect of genetic polymorphisms and environmental factors on
the progression from Mild Cognitive Impairment (MCI) to AD (MCI-AD progression) in a Chinese
community cohort.

Conclusion:

Demographic, DNA and incident AD diagnosis data were derived from the follow-up of 316
participants with MCI at baseline of the Shanghai Aging Study. The associations of 40 SNPs and environmental
predictors with MCI-AD progression were assessed using the Kaplan-Meier method with the
log-rank test and Cox regression model.

Results:

Rs4147929 at ATP-binding cassette family A member 7 (ABCA7) (AG/AA vs. GG, hazard ratio
[HR] = 2.43, 95% confidence interval [CI] 1.24-4.76) and body mass index (BMI) (overweight vs.
non-overweight, HR = 0.41, 95% CI 0.22-0.78) were independent predictors of MCI-AD progression. In
the combined analyses, MCI participants with the copresence of non-overweight BMI and the ABCA7
rs4147929 (AG/AA) risk genotype had an approximately 6-fold higher risk of MCI-AD progression
than those with an overweight BMI and a non-risk genotype (HR = 6.77, 95% CI 2.60-17.63). However,
a nonsignificant result was found when participants carried only one of these two risk factors (nonoverweight
BMI and AG/AA of ABCA7 rs4147929).

Conclusion:

ABCA7 rs4147929 and BMI jointly affect MCI-AD progression. MCI participants with the
rs4147929 risk genotype may benefit from maintaining an overweight BMI level with regard to their
risk for incident AD.
Detection of Mild Cognitive Impairment Based on Virtual Reality: A Scoping Review
Authors: Wang Shuo , Yin Huiru , Li Guichen , Jia Yong , Leng Minmin , Meng Qiuyan , Wang Chunyan , Chen Li
Published: March 2020

Background:

To delay the decline in cognition and reduce the incidence of dementia, the
precise detection of Mild Cognitive Impairment (MCI) is necessary. The application of Virtual Reality
(VR) technology in this detection can overcome the shortage of traditional paper-and-pencil tests.

Objective:

This review aimed to summarize the research progress of the detection of MCI using VR.

Methods:

Eight databases from their inception to November 19, 2019, were systematically searched for
studies applying VR in the detection of MCI. A thematic analysis was conducted according to the specific
detection purpose and the main corresponding cognitive domains assessed were summarized; characteristics
of the VR applications were also summarized.

Results:

Twenty-eight studies were finally included. The detection purposes included discrimination
between healthy controls and those with MCI, discrimination between aMCI subtypes, detection of MCI
patients at risk of Alzheimer’s Disease (AD), and discrimination between MCI and AD. VR tasks assessing
spatial memory were applicable for all detection purposes, and the assessment of combinations
of memory and executive function seemed more sensitive. Executive function and intentional episodic
memory could be assessed to discriminate among healthy controls, individuals with MCI and those with
AD. Incidental episodic memory was effective in detecting MCI with hippocampal atrophy. The most
common characteristics of the VR applications were the use of semi-immersion, joysticks or gamepad
interactions and simple, one-time behavioral assessments.

Conclusion:

VR applications are promising in the detection of MCI, but further research is needed for
clinical use.
Association Between Anemia and Dementia: A Nationwide, Populationbased Cohort Study in Taiwan
Authors: Hong Chien-Tai , Hsieh Yi-Chen , Liu Hung-Yi , Chiou Hung-Yi , Chien Li-Nien
Published: March 2020

Background:

In addition to the traditional risk predictors, whether anemia is an early biomarker
of dementia, needs to be confirmed.

Objective:

This population-based cohort study aimed to investigate the dementia risk in patients with
newly diagnosed anemia using data from the Taiwan National Health Insurance Research Database.

Methods:

All newly diagnosed anemia patients (n = 26,343) with no history of stroke hospitalization,
central nervous disease other than dementia, psychiatric disorders, traumatic brain injury, major operations,
or blood loss diseases, were enrolled. A group of non-anemic controls, 1:4 matched with anemic
patients on the basis of demographics and comorbidities, was also included. A competing risk analysis
was used to evaluate the dementia risk in anemic patients compared to that of their matched controls.

Results:

The adjusted subdistribution hazard ratio (SHR) of dementia risk in anemic patients was 1.14
(95% confidence interval [CI]: 1.08~1.21, p<0.001). Patients with iron supplements tended to exhibit a
lower dementia risk (adjusted SHR: 0.84; 95% CI: 0.75~0.94, p=0.002) compared to patients without
iron supplement. A subgroup analysis showed that a positive association between dementia and anemia
existed in females, those aged 70 years and older, and patients without hypertension, diabetes, or hyperlipidemia.

Conclusion:

The present population-based cohort study identified that newly diagnosed anemia is a risk
factor for dementia and also that iron supplementation was able to reduce the risk of dementia in people
with iron deficiency anemia.
Association between ALDH2 Gene Polymorphism and Late-onset Alzheimer Disease: An Up-to-date Meta-analysis
Authors: Liu Haitao , Ge Wei , Chen Wei , Kong Xue , Jian Weiming , Wang Anhui
Published: March 2020

Objectives:

Previous case-control studies have focused on the relationship between ALDH2
gene polymorphism and late-onset Alzheimer's Disease (LOAD), but no definite unified conclusion has
been reached. Therefore, the correlation between ALDH2 Glu504Lys polymorphism and LOAD remains
controversial. To analyze the correlation between ALDH2 polymorphism and the risk of LOAD, we implemented
this up-to-date meta-analysis to assess the probable association.

Methods:

Studies were searched through China National Knowledge Infrastructure (CNKI), VIP Database
for Chinese Technical Periodicals, China Biology Medicine, PubMed, Cochrane Library, Clinical-
Trials.gov, Embase, and MEDLINE from January 1, 1994 to December 31, 2018, without any restrictions
on language and ethnicity.

Results:

Five studies of 1057 LOAD patients and 1136 healthy controls met our criteria for the analysis.
Statistically, the ALDH2 GA/AA genotype was not linked with raising LOAD risk (odds ratio (OR) =
1.48, 95% confidence interval (CI) = 0.96-2.28, p = 0.07). In subgroup analysis, the phenomenon that
men with ALDH2*2 had higher risk for LOAD (OR = 1.72, 95%CI = 1.10-2.67, p = 0.02) was observed.

Conclusions:

This study comprehends only five existing case-control studies and the result is negative.
The positive trend might appear when the sample size is enlarged. In the future, more large-scale casecontrol
or cohort studies should be done to enhance the association between ALDH2 polymorphism and
AD or other neurodegenerative diseases.
Prognostic Significance of Relative Hyperglycemia after Percutaneous Coronary Intervention in Patients with and without Recognized Diabetes
Authors: Zhao Qi , Zhang Ting-Yu , Cheng Yu-Jing , Ma Yue , Xu Ying-Kai , Yang Jia-Qi , Zhou Yu-Jie
Published: March 2020

Background:

The research on the association between the relative glycemic level postpercutaneous
coronary intervention (PCI) and adverse prognosis in non-ST-segment elevation acute
coronary syndrome (NSTE-ACS) patients is relatively inadequate.

Objective:

The study aimed to identify whether the glycemic level post-PCI predicts adverse prognosis
in NSTE-ACS patients.

Methods:

Patients (n=2465) admitted with NSTE-ACS who underwent PCI were enrolled. The relative
glycemic level post-procedure was calculated as blood glucose level post-PCI divided by HbA1c level,
which was named post-procedural glycemic index (PGI). The primary observational outcome of this
study was major adverse cardiovascular events (MACE) [defined as a composite of all-cause death,
non-fatal myocardial infarction (MI) and any revascularization].

Results:

The association between PGI and MACE rate is presented as a U-shape curve. Higher PGIs
[hazard ratio (HR): 1.669 (95% confidence interval (CI): 1.244-2.238) for the third quartile (Q3) and
2.076 (1.566-2.753) for the fourth quartile (Q4), p<0.001], adjusted for confounding factors, were considered
to be one of the independent predictors of MACE. The association between the PGI and the risk
of MACE was more prominent in the non-diabetic population [HR (95%CI) of 2.356 (1.456-3.812) for
Q3 and 3.628 (2.265-5.812) for Q4, p<0.001]. There were no significant differences in MACE risk between
PGI groups in the diabetic population.

Conclusion:

Higher PGI was a significant and independent predictor of MACE in NSTE-ACS patients
treated with PCI. The prognostic effect of the PGI is more remarkable in subsets without pre-existing
diabetes than in the overall population. The predictive value of PGI was not identified in the subgroup
with diabetes.
Biomarker Identification for Liver Hepatocellular Carcinoma and Cholangiocarcinoma Based on Gene Regulatory Network Analysis
Authors: Huo Qiuyan , Ma Yuying , Yin Yu , Qin Guimin
Published: March 2020

Background:

Liver hepatocellular carcinoma (LIHC) and cholangiocarcinoma (CHOL)
are two main histological subtypes of primary liver cancer with a unified molecular landscape, and
feed-forward loops (FFLs) have been shown to be relevant in these complex diseases.

Objective:

To date, there has been no comparative analysis of the pathogenesis of LIHC and CHOL
based on regulatory relationships. Therefore, we investigated the common and distinct regulatory
properties of LIHC and CHOL in terms of gene regulatory networks.

Method:

Based on identified FFLs and an analysis of pathway enrichment, we constructed pathway-specific co-expression networks and further predicted biomarkers for these cancers by network clustering.

Resul:

We identified 20 and 36 candidate genes for LIHC and CHOL, respectively. The literature
from PubMed supports the reliability of our results.

Conclusion:

Our results indicated that the hsa01522-Endocrine resistance pathway was associated
with both LIHC and CHOL. Additionally, six genes (SPARC, CTHRC1, COL4A1, EDIL3, LAMA4
and OLFML2B) were predicted to be highly associated with both cancers, and COL4A2, CSPG4,
GJC1 and ADAMTS7 were predicted to be potential biomarkers of LIHC, and COL6A3, COL1A2,
FAP and COL8A1 were predicted to be potential biomarkers of CHOL. In addition, we inferred that
the Collagen gene family, which appeared more frequently in our overall prediction results, might be
closely related to cancer development.
Cytotoxic Dehydroabietylamine Derived Compounds
Authors: Wiemann Jana , Al-Harrasi Ahmed , Csuk René
Published: March 2020

Background and Methods:

Chemotherapy remains one of the most important methods for the treatment of
cancer. More recently in this context, some products derived from natural products have raised scientific interest which
especially include many terpenes. Thereby, diterpenoids represent a special class, and within this class of important
secondary natural products, especially compounds derived from Dehydroabietylamine (DA), are of particular interest.

Results:

This review not only gives a summary of the most important findings on the cytotoxic behavior of DAderived
compounds but also shows some drawbacks of these compounds, such low bioavailability and/or poor solubility
of several derivatives of DA. It focusses on the chemical aspects and summarizes the DA related biological
effects without deep discussion of underlying biochemical pathways.

Conclusion:

Dehydroabietylamine-derived cytotoxic compounds hold a high potential to be developed into efficient
antitumor active drugs.
Community Psychiatry in a Latin American Context: Perú as a Case Example
Authors: Alarcón Renato D. , Vargas-Murga Horacio , Caballero-Peralta July , Cutipé-Cárdenas Yuri
Published: March 2020

Background:

Historical and conceptual issues related to community psychiatry as
an innovative approach to clinical assistance across the world, precede a more or less detailed
examination of its presence, role and current accomplishments in Latin America, particularly
related to child and adolescent subpopulations. Information about transition processes
from the traditional hospital-centered model to the community-based approach, applicable
mental health policies, levels of implementation and quality of the available reports in
different countries, are duly evaluated.

Objective:

Within an understanding of the broader Latin American context, the paper describes
the situation in Perú, a country considered representative of the Low and Middle Income
(LMIC) group in the subcontinent.

Methods:

The situation in Perú is presented with particular emphasis on a recently established
community-based mental health centers program across its territory.

Results:

This description includes consideration of variables such as personal, family and
identity empowerment, a focus on integrated care, and clinical outcomes and community relations.
The development of community mental health centers across Perú is described.

Conclusion:

Adolescents represent the unique future of socio-culturally diverse Latin
American countries, and must be the target population of well-conceived, cohesive community
mental health policies and programs. The importance of political will to promote community
health centers that provide adolescents access to services is critical.
Az önkéntes munkanélküli biztosítás szerepe a szakszervezeti mozgalomban
Authors: Elek Nora Ilona
Published: March 2020

A tanulmány célja, hogy a szakirodalom alapján feltérképezze a szakszervezet által kezelt, állami támogatással működő, országos szintű, önkéntes munkanélküli biztosítási rendszer, az ún. Ghent-rendszer, szelektív ösztönzést befolyásoló intézményi környezetét. További cél, hogy klaszterelemzés alkalmazásával megvizsgálja, hogy e környezet alapján a Ghent-rendszerű országok – Dánia, Finnország és Svédország – különböznek-e más országoktól. Az elemzés Olson (1965) melléktermék-elméletének koncepciójából indul ki. Ennek lényege, hogy a nagy csoportok az egyes egyénekre ható ösztönzők alkalmazásával képesek csak a tagságuk növelésére, fenntartására és így lobbitevékenységük megvalósítására. A szakszervezetek esetében az önkéntes munkanélküli biztosítás elérhetősége lényeges ösztönző. A szakszervezeti mozgalomra gyakorolt hatását dummy változóként szokták vizsgálni, jelen írás azonban a Ghent-rendszer szempontjából fontos intézményekre fókuszál.

Journal of Economic Literature (JEL) kód: J51
Kornai 90
Authors: Ricz Judit , Siger Fruzsina
Published: March 2020

A Budapesti Corvinus Egyetem 2018-ban több rendezvénnyel is tiszteleg Kornai János előtt, aki januárban ünnepelte 90. születésnapját. Kornai jelenleg a Budapesti Corvinus Egyetem kötelékébe tartozik, az Összehasonlító és Intézményi Gazdaságtan Tanszék tiszteletbeli professor emeritusa, és többek között – 2001júniusa óta – a Debreceni Egyetem díszdoktora. A 2018. január 18-án tartott egész napos angol nyelvű tudományos tanácskozás házigazdája az Összehasonlító és Intézményi Gazdaságtan Tanszék vezetője, Rosta Miklós egyetemi docens volt.
Hálózatelemzés a piacfelügyeleti munkában
Authors: Szots Gergely , Nagy Gabor
Published: March 2020

A hitel-nemteljesítési csereügyletek (angol rövidítésük CDS, credit default swap) piachálózatának elemzéséről eddig kevés publikáció jelent meg, ezért került elemzésünk fókuszába a CDS termékek piaca. Elemzésünk súlypontja a piaci visszaélések felderítésének újszerű, a hálózatkutatás eszközeit felvonultató alkalmazása a hazai piacra. A kapott eredményeket összevetjük az Európai Értékpapír-piaci Hatóság (ESMA) egy korábban publikált elemzésével, amelyben a kutatók a hálózatelemzés eszközeit a kockázatok és pénzügyi válságok fertőzés útján történő terjedésének feltárásához használták. Az elemzés eredményeit összevetve az európai kutatásokkal az látszik, hogy a magyar vonatkozású CDS piac az európaihoz hasonlóan erős koncentráltságot mutat.

Journal of Economic Literature (JEL) kódok: G14, C45
Gröxit: Grönland esete az Európai Közösséggel
Authors: Siger Fruzsina
Published: March 2020

A Brexit tárgyalások kapcsán különösen érdekessé és újra aktuálissá vált az EU történetének a hazai köztudatban kevésbé ismert epizódja: Grönland 1973-ban Dániával együtt belépett, majd 1985-ban kilépett az Európai Közösségből. A tanulmány áttekintést ad Grönland be- és kilépésének körülményeiről, majd összehasonlító elemzésre vállalkozik. Egyrészt az Egyesült Királyság tervezett kilépésének fényében vizsgálja a Gröxitet, másrészt Izland majdnem-belépésével veti össze. A tanulmány arra jut, hogy Grönland esete kulcsfontosságú részleteit tekintve egyáltalán nem hasonlít a Brexitre, ugyanakkor lényegi tanulságként levonható, hogy a két terület szuverenitásában és gazdasági, politikai súlyában mutatkozó különbségek alapvetően magyarázzák az EK/EU hozzáállását a kilépéshez. Az Izlanddal való összevetésből a halászati szektor fontossága adódik.

Journal of Economic Literature (JEL) kódok: F53, P52
Support System for Early Diagnosis of Chronic Obstructive Pulmonary Disease Based on the Service-Oriented Architecture Paradigm and Business Process Management Strategy: Development and Usability Survey Among Patients and Health Care Providers
Authors: De Ramón Fernández Alberto , Ruiz Fernández Daniel , Marcos-Jorquera Diego , Gilart Iglesias Virgilio
Published: March 2020

Background

Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disease with a high global prevalence. The main scientific societies dedicated to the management of this disease have published clinical practice guidelines for quality practice. However, at present, there are important weaknesses in COPD diagnosis criteria that often lead to underdiagnosis or misdiagnosis.

Objective

We sought to develop a new support system for COPD diagnosis. The system was designed to overcome the weaknesses detected in current guidelines with the goals of enabling early diagnosis, and improving the diagnostic accuracy and quality of care provided.

Methods

We first analyzed the main clinical guidelines for COPD to detect weaknesses that exist in the current diagnostic process, and then proposed a redesign based on a business process management (BPM) strategy for its optimization. The BPM system acts as a backbone throughout the process of COPD diagnosis in this proposed approach. The newly developed support system was integrated into a health information system for validation of its use in a hospital environment. The system was qualitatively evaluated by experts (n=12) and patients (n=36).

Results

Among the 12 experts, 10 (83%) positively evaluated our system with respect to increasing the speed for making the diagnosis, helping in interpreting results, and encouraging opportunistic diagnosis. With an overall rating of 4.29 on a 5-point scale, 27/36 (75%) of patients considered that the system was very useful in providing a warning about possible cases of COPD. The overall assessment of the system was 4.53 on a 5-point Likert scale with agreement to extend its use to all primary care centers.

Conclusions

The proposed system provides a functional method to overcome the weaknesses detected in the current diagnostic process for COPD, which can help foster early diagnosis, while improving the diagnostic accuracy and quality of care provided.
Agile Health Care Analytics: Enabling Real-Time Disease Surveillance With a Computational Health Platform (Preprint)
Authors: Schulz Wade L , Durant Thomas J S , Torre Jr Charles J , Hsiao Allen L , Krumholz Harlan M
Published: March 2020

UNSTRUCTURED

The ongoing coronavirus disease outbreak demonstrates the need for novel applications of real-time data to produce timely information about incident cases. Using health information technology (HIT) and real-world data, we sought to produce an interface that could, in near real time, identify patients presenting with suspected respiratory tract infection and enable monitoring of test results related to specific pathogens, including severe acute respiratory syndrome coronavirus 2. This tool was built upon our computational health platform, which provides access to near real-time data from disparate HIT sources across our health system. This combination of technology allowed us to rapidly prototype, iterate, and deploy a platform to support a cohesive organizational response to a rapidly evolving outbreak. Platforms that allow for agile analytics are needed to keep pace with evolving needs within the health care system.
Effectiveness of foot reflex therapy in postoperative pain among patients subjected to major abdominal surgery (Preprint)
Authors: Mohan Poongodi
Published: March 2020

BACKGROUND

Most of the patients experience post – operative pain and it is unavoidable. It is the duty of the nurses to ensure that patients' pain is assessed and managed effectively when they are at the hospital. Foot reflex therapy is one effective way the nurses can adopt to manage post-operative pain in patients.

OBJECTIVE

This study aims to prove the effectiveness of foot reflex therapy in post-operative pain in patients who are subjected to major abdominal surgery

METHODS

This is a descriptive randomized control study that was conducted in the period month of Jan 2012 to Sep 2013 at Sri Ramachandra Medical College and Hospital among 360 patients who underwent major abdominal surgery. They were equally divided into two groups as control and study group and the results were analyzed statistically.

RESULTS

A majority of the patients in the study group showed a positive effect in the 4th and 5th post-operative day following foot reflex therapy.

CONCLUSIONS

The pre – existing pain and the post – operative pain is managed as collaboration along with nurses, patients, their care takers or families whenever appropriate in a multidisciplinary manner. Foot reflex therapy is one such alternative complementary therapy which the nurses can adopt to work in this accord.

CLINICALTRIAL

Not Required. Ethics Committee Approval Obtained
Consideraciones sobre la fuerza de las razones en contra de dañar
Authors: Truccone Borgogno Santiago
Published: March 2020

En este trabajo realizaré afirmaciones sobre la fuerza de las razones en contra de dañar. Distinguiré diferentes tipos de estados de daño y de acciones dañosas. Explicaré qué tipo de estado de daño es más grave y qué tipo de acción dañosa genera razones más fuertes en contra de dañar. Finalmente compararé la fuerza de las razones en contra de dañar derivadas tanto de los estados de daño como de los distintos tipos de acciones dañosas, para establecer una regla de prioridadentre ellas.
Causalidad y emergencia
Authors: Castillo Santiago Ramón
Published: March 2020

Se propone entender la relación mente-cuerpo partiendo del emergentismo, aunque esta propuesta no ha estado exenta de dificultades. Los esfuerzos del fisicalismo emergentista por encontrar poderes causales en lo mental han derivado en un liminativismo de lo mental o a aceptarlo como fenómeno superveniente. En este artículo se intenta mostrar lo mental como un estadio emergente de lo físico pero sin pérdida de propiedades, pasando necesariamente por lo biológico como otro estadio de lo físico. Las propiedades mentales y biológicas, entonces, no se restringen a un ámbito separado del mundo físico, sino que constituyen formas diferentes de la fisicalidad pura.
La comicidad como perjuicio de sujetos intencionales
Authors: Pérez Otero Manuel
Published: March 2020

En este artículo presento, clarifico y exploro algunas virtudes potenciales de una determinada teoría —de carácter intencionalista— sobre lo cómico. Su tesis mínima principal establece una condición necesaria para la comicidad: quien evalúaaprecia una situación como humorística/cómica reconoce un perjuicio o daño ocasionado a ciertos sujetos intencionales (pueden ser sujetos involucrados en la situación cómica, o el propio evaluador-apreciador). Una versión más fuerte establece que la comicidad deriva (al menos en parte) de dicho perjuicio. El perjuicio es aquello que, cuando se combina con otros factores, encontramos humorístico/cómico. Clarificar la teoría conlleva una tarea de comparación con otras concepciones del humor, en particular, con la teoría de la incongruencia.
The Lexicon of Kaliuda to Improve the Student’s Descriptive Writing Text
Authors: Rija Tatu , Yadnya Ida bagus Putra , Sutama Putu
Published: March 2020

This study aims to determine the kinds of lexicon discovered in kaliuda that has several motive so the students can learn and finding out the lexicon that improve students’ writing descriptive text. Because by studying and multiplying the vocabulary the students will be easier to write the descriptive text. Students’ ability to write descriptive text relates to mastery of vocabulary. Mastery vocabulary as a basic for mastering language skills that can increase students’ ability to express and writing as productive skill. The method of data collection in this study were obtained by observation consist of several technic, observe the students’ learning process then continued by data arranging suitable with lexicon that contained in Kaliuda as a learning media. The data obtained was conveyed by qualitative method. The students’ writing skill can increase of lexicon was found from kaliuda. The result of this study show that kaliuda has many lexicon inside. At the beginning the students asked to find out the various motive to described it. Based on the students’ descriptions of the kaliuda is able to make the students improve their writing descriptive text skill. By using kaliuda motive the students directly imagine what they will learn such as the lexicon, language use, and etc. Kaliuda as description quite interesting and good to enrich their vocabularies in order to improve the capability of writing descriptive text.
Values of Life in Mitch Albom’s “Tuesday With Morrie”
Authors: Suarniti Gusti Ayu Made Rai
Published: March 2020

The title of this research is Values of Life in Mitch Albom’s Tuesday With Morrie. This research focuses on analyzing the types of values which are found in novel Tuesday With Morrie. This study aims to analyze the types of value of live on the novel Tuesday With Morrie and describe its implementation in human’s life. There are four methods of research used in this paper, they are: finding data resource, collecting and clasifying the data, analyzing the data, and the last is presenting the result of the analysis. All of the data used in the research are taken from Albom’s Tuesday With Morrie. The result of the analysis showed that in general there are two kinds of value found, they are entertainment value and educational value. Based on the educational value, there are three values found, such as society and civilizations value, moral – ethic – religion value, and practical value. The result of the study also showed that all of the all datacan be implemented in daily human’s life.