bluuebunny/crossref_metadata_2025 huggingface dataset:
Thyroid function during prolonged exposure to fluorides
Authors: Mikhailets N. D. , Balabolkin M. I. , Rakitin V. A. , Danilov I. P.
Published: October 2019

Thyroid function was examined in 165 workers of electrolysis shops of aluminum production with more or less expressed signs of chronic fluoride intoxication (fluorosis) by radioimmunoassay of hormones and the test of 13II absorption by the thyroid. The detected thyroid abnormalities were characterized by a moderate reduction of iodine-absorbing function of the thyroid, low T3 with normal T4 level, and a slight increase of TTH concentration. These changes augmented with longer service and fluorosis progress. Hence, the syndrome of low T3 and reduced absorption of 1311 may be considered as diagnostic signs of fluorosis. In case of toxic involvement of the liver in fluorosis patients, low T3 syndrome is observed much more frequently: in 75.6% cases. Liver abnormalities evidently lead to disorders in the peripheral conversion of T4 in T3, occurring primarily in liver parenchyma. Indirect effect of fluorine on the enzymatic system of deiodination cannot be ruled out as well.
HLA antigens in nodular formations of the thyroid
Authors: Rasovsky В. L. , Dimova M. N. , Kiselyova T. P. , Akhmedyanova L. G. , Minina V. M.
Published: October 2019

Distribution of the HLA system Class 1 specificities was studied in 97 patients with thyroid carcinoma, 101 ones with nodular goiter and 500 donors in the Central Urals. B15, B18 antigens were very frequent and All antigens quite rare in the patients with thyroid carcinoma; in patients with nodular goiter the incidence of Awl9, A28, B18 antigens was the highest, whereas the incidence of All antigen and the A2-B35 haplotype was low. The groups of patients with thyroid carcinoma and nodular goiter differed only by the incidence of A28 antigen and A2-B35 haplotype, this fact indicating the immunogenetic similarity of the diseases in question. Similar pathogenetic mechanisms of the formation of mammary carcinoma and of nodular goiter in the thyroid may be supposed, this giving grounds for the radical approach to the treatment of nodular formations of the thyroid.
In memory of K. N. Kazeyev
Authors: Problems of endocrinology Editorial team of
Published: October 2019

On October 5, 1992, at the age of 62, a major surgeon-endocrinologist, doctor of medical Sciences, Professor Konstantin Nikolayevich Kazeev died. The whole working life of Konstantin Nikolaevich was connected with the Institute of endocrinology. He joined it in 1957 as a graduate student and worked until the very last day, going from Junior researcher to head of the Department, which he led for 17 years. Konstantin Nikolayevich Kazeev was considered to be one of the leading Russian endocrine surgeons. He performed more than 3 thousand operations on endocrine glands, had the largest experience in Europe in the surgical treatment of pheochromocytoma. K. N. Kazeev generously shared his experience, vast knowledge, paid much attention to pedagogical activity. Endocrine surgeons trained by him successfully work in different regions of the country. He was respected by colleagues and loved by patients. He always worked hard. Many thousands of patients owe their health to him.
Distribution of the total quantity of fatty acid double bonds in lipid components of the blood in children with diabetes mellitus
Authors: Turkina T. I. , Marchenko L. F. , Sapelkina L. V. , Poznyak T. I. , Kiselyova Ye. V.
Published: October 2019

Children suffering from insulin-dependent diabetes mellitus (IDDM) were examined for unsaturation, that is, total quantity of double bonds in individual fractions of blood serum lipids was assessed. Lipid fractions were isolated by thin-layer chromatography. Unsaturation was assessed by ozonation method. The research was aimed at elucidation of biochemical criteria of the degree of metabolic disorders in children with IDDM and at development of methods for quantitative assessment of such disorders. Thirty-two inpatients with IDDM aged 7 to 15 were examined over time. Control group included 10 healthy age-matched children. Twenty children were examined during compensation stage (group 1), twelve during decompensation with ketoacidosis (group 2). Total unsaturation parameters were found reliably decreased in children with IDDM both during compensation and decompensation stages vs. those in healthy controls. A relative decrease of unsaturated fatty acids in the fraction of uneterified fatty acids (p0.05) was characteristic of group 2, with the content of their fragments in triglyceride fraction being the maximal (p0.05). The pattern of total unsaturation distribution in serum lipid fractions may serve as an indicator for metabolic disorders and decompensation in IDDM.
Theu+gen construction in Modern Standard Russian
Authors: Luraghi Silvia , Naccarato Chiara , Pinelli Erica
Published: October 2019

In Modern Standard Russian (MSR), the prefix/preposition pairu-/uis peculiar with respect to other similar pairs, due to the meaning mismatch between the two. While the prefixu- has an ablative meaning, as shown when it is prefixed to motion verbs, the prepositional phraseu+gen occurs in locative constructions, and other related constructions, such as predicative possession that is expressed via the cross-linguistically common Locative Schema. Etymological considerations show that the meaning preserved by the prefix is older. The only type of occurrence which, according to the literature, preserves the ablative meaning for theu+gen construction is found with verbs of requesting, removing, and buying. Notably, however, in other Slavic languages putative ablative contexts are limited to verbs of requesting. Data from MSR, Old Church Slavic, Polish and Czech lead to the conclusion that the extension of theu+gen construction to verbs of removing in MSR is based on its use for the encoding of predicative possession. Extension to verbs of buying is better explained through the locative meaning of the construction. As a result of different developments, theu+gen construction has become part of the argument structure of a group of verbs including verbs of asking and requesting, verbs of removing, and verbs of buying, which are characterized by the common feature of taking human non-recipient third arguments. We argue that the different usages of theu+gen construction in MSR constitute an instance of constructionalization based on the merger of originally different constructions. We further argue that accounting for this development in constructional terms offers better insights in the relation among the various different usages ofu+gen than simply focusing on the meaning of the preposition and its polysemy pattern.
Large placental chorioangioma: a potential effective in-utero treatment modality for radio frequency ablation
Authors: Yulia Angela , Chelemen Oana , Bhutani Ruchi , Hutchinson Ciaran , Levine Samantha , Kamel Dia , Wimalasundera Ruwan
Published: October 2019

Background

Placenta chorioangiomas are common benign placental tumours. While microscopic chorioangiomas are frequent, macroscopic chorioangiomas of more than 5 cm are rare and often associated with fetal complications such as high output cardiac failure, fetal anaemia and stillbirth. Close monitoring and in-utero treatment are sometimes necessary to prevent adverse pregnancy outcome.

Case presentation

We present two cases of large placenta chorioangiomas with one case requiring surgical therapy with radiofrequency ablation (RFA) of tumour vessels, which resulted in a successful outcome of a live birth at term.

Conclusion

We conclude that RFA is an effective alternative treatment modality to fetoscopic laser therapy in utero for cases at risk of fetal cardiac failure and intrauterine demise in the presence of large chorioangiomas.
Converting GTP hydrolysis into motion: versatile translational elongation factor G
Authors: Rodnina Marina V. , Peske Frank , Peng Bee-Zen , Belardinelli Riccardo , Wintermeyer Wolfgang
Published: October 2019

Elongation factor G (EF-G) is a translational GTPase that acts at several stages of protein synthesis. Its canonical function is to catalyze tRNA movement during translation elongation, but it also acts at the last step of translation to promote ribosome recycling. Moreover, EF-G has additional functions, such as helping the ribosome to maintain the mRNA reading frame or to slide over non-coding stretches of the mRNA. EF-G has an unconventional GTPase cycle that couples the energy of GTP hydrolysis to movement. EF-G facilitates movement in the GDP-Pi form. To convert the energy of hydrolysis to movement, it requires various ligands in the A site, such as a tRNA in translocation, an mRNA secondary structure element in ribosome sliding, or ribosome recycling factor in post-termination complex disassembly. The ligand defines the direction and timing of EF-G-facilitated motion. In this review, we summarize recent advances in understanding the mechanism of EF-G action as a remarkable force-generating GTPase.
The Ras switch in structural and historical perspective
Authors: Gasper Raphael , Wittinghofer Fred
Published: October 2019

Since its discovery as an oncogene more than 40 years ago, Ras has been and still is in the focus of many academic and pharmaceutical labs around the world. A huge amount of work has accumulated on its biology. However, many questions about the role of the different Ras isoforms in health and disease still exist and a full understanding will require more intensive work in the future. Here we try to survey some of the structural findings in a historical perspective and how it has influenced our understanding of structure-function and mechanistic relationships of Ras and its interactions. The structures show that Ras is a stable molecular machine that uses the dynamics of its switch regions for the interaction with all regulators and effectors. This conformational flexibility has been used to create small molecule drug candidates against this important oncoprotein.
Implication of glycogen synthase kinase 3 in diabetes-associated islet inflammation
Authors: Pitasi Caterina Luana , Liu Junjun , Gausserès Blandine , Pommier Gaëlle , Delangre Etienne , Armanet Mathieu , Cattan Pierre , Mégarbane Bruno , Hanak Anne-Sophie , Maouche Kamel , Bailbé Danielle , Portha Bernard , Movassat Jamileh
Published: October 2019

Islet inflammation is associated with defective β cell function and mass in type 2 diabetes (T2D). Glycogen synthase kinase 3 (GSK3) has been identified as an important regulator of inflammation in different diseased conditions. However, the role of GSK3 in islet inflammation in the context of diabetes remains unexplored. In this study, we investigated the direct implication of GSK3 in islet inflammation in vitro and tested the impact of GSK3 inhibition in vivo, on the reduction of islet inflammation, and the improvement of glucose metabolism in the Goto-Kakizaki (GK) rat, a spontaneous model of T2D. GK rats were chronically treated with infra-therapeutic doses of lithium, a widely used inhibitor of GSK3. We analyzed parameters of glucose homeostasis as well as islet inflammation and fibrosis in the endocrine pancreas. Ex vivo, we tested the impact of GSK3 inhibition on the autonomous inflammatory response of non-diabetic rat and human islets, exposed to a mix of pro-inflammatory cytokines to mimic an inflammatory environment. Treatment of young GK rats with lithium prevented the development of overt diabetes. Lithium treatment resulted in reduced expression of pro-inflammatory cytokines in the islets. It decreased islet fibrosis and partially restored the glucose-induced insulin secretion in GK rats. Studies in non-diabetic human and rat islets exposed to inflammatory environment revealed the direct implication of GSK3 in the islet autonomous inflammatory response. We show for the first time, the implication of GSK3 in islet inflammation and suggest this enzyme as a viable target to treat diabetes-associated inflammation.
PGE2 inhibits spermatogonia differentiation in zebrafish: interaction with Fsh and an androgen
Authors: Crespo Diego , Lemos Moline Severino , Zhang Yu Ting , Safian Diego , Norberg Birgitta , Bogerd Jan , Schulz Rüdiger W
Published: October 2019

Changes in zebrafish testicular gene expression induced by follicle-stimulating hormone (Fsh) or anti-Mullerian hormone (Amh) suggested that Amh inhibition and Fsh stimulation of spermatogenesis involved up and downregulation, respectively, of prostaglandin (PG) signaling. We found that Sertoli cells contacting type A undifferentiated (Aund) and differentiating (Adiff) spermatogonia expressed a key enzyme of PG production (Ptgs2); previous work showed that Sertoli cells contacting Adiff and B spermatogonia and spermatocytes showed ptges3b expression, an enzyme catalyzing PGE2 production. In primary testis tissue cultures, PGE2, but not PGD2 or PGF2α, reduced the mitotic activity of Adiff and their development into B spermatogonia. Vice versa, inhibiting PG production increased the mitotic activity of Adiff and B spermatogonia. Studies with pharmacological PG receptor antagonists suggest that an Ep4 receptor mediates the inhibitory effects on the development of spermatogonia, and cell-sorting experiments indicated this receptor is expressed mainly by testicular somatic cells. Combined inhibition of PG and steroid production moreover reduced the mitotic activity of Aund spermatogonia and led to their partial depletion, suggesting that androgens (and/or other testicular steroids), supported by PGE2, otherwise prevent depletion of Aund. Androgens also decreased testicular PGE2 production, increased the transcript levels of the enzyme-catabolizing PGs and decreased PGE2 receptor ptger4b transcript levels. Also Fsh potentially reduced, independent of androgens, PGE2 production by decreasing ptges3b transcript levels. Taken together, our results indicate that PGE2, via Ep4 receptors, favors self-renewal in conjunction with androgens and, independent of Fsh and androgens, inhibits differentiating divisions of spermatogonia.
Targeted Forward Genetics: Population-Scale Analyses of Allele Replacements Spanning Thousands of Base Pairs in Fission Yeast
Authors: Storey Aaron J , Wang Hsin-Ping , Protacio Reine U , Davidson Mari K , Wahls Wayne P
Published: October 2019

Precise allele replacement (genome editing), without unwanted changes to the genome, provides a powerful tool to define the functions of DNA elements and encoded factors in their normal biological context. While CRISPR is now used extensively for gene targeting, its utility for precise allele replacement at population scale is limited because: (A) there is a strict requirement for a correctly positioned PAM motif to introduce recombinogenic dsDNA breaks (DSBs); (B) efficient replacements only occur very close to the DSBs; and (C) indels and off-target changes are frequently generated. Here we show, using a saturated mutation library with about 15,000 alleles of the ade6 gene of Schizosaccharomyces pombe, that pop-in, pop-out allele replacement circumvents these problems. Two rounds of selection ensure that clones arise by homologous recombination with the target locus. Moreover, the exceptionally high efficiency allows one to carry out the process in bulk, then screen individual clones for phenotypes and genotypes. Alleles were introduced successfully throughout the region targeted, up to 1,956 base pairs from the DSB. About 11% of mutant alleles were hypomorphic, demonstrating utility for analyses of essential genes and genetic elements. This process of “targeted forward genetics” can be used to analyze comprehensively, across thousands of base pairs within a specific target region, a variety of allelic changes, such as scanning amino acid substitutions, deletions, and epitope tags. The overall approach and optimized workflow are extensible to other organisms that support gene targeting.
Distinct Functions in Regulation of Meiotic Crossovers for DNA Damage Response Clamp Loader Rad24(Rad17) and Mec1(ATR) Kinase
Authors: Shinohara Miki , Bishop Douglas K , Shinohara Akira
Published: October 2019

The number and distribution of meiotic crossovers (COs) are highly regulated, reflecting the requirement for COs during the first round of meiotic chromosome segregation. CO control includes CO assurance and CO interference, which promote at least one CO per chromosome bivalent and evenly-spaced COs, respectively. Previous studies revealed a role for the DNA damage response (DDR) clamp and the clamp loader in CO formation by promoting interfering COs and interhomolog recombination, and also by suppressing ectopic recombination. In this study, we use classical tetrad analysis of Saccharomyces cerevisiae to show that a mutant defective in RAD24, which encodes the DDR clamp loader (RAD17 in other organisms), displayed reduced CO frequencies on two shorter chromosomes (III and V), but not on a long chromosome (chromosome VII). The residual COs in the rad24 mutant do not show interference. In contrast to rad24, mutants defective in the ATR kinase homolog Mec1, including a mec1 null and a mec1 kinase-dead mutant, show slight or few defects in CO frequency. On the other hand, mec1 COs show defects in interference, similar to the rad24 mutant. Our results support a model in which the DDR clamp and clamp-loader proteins promote interfering COs by recruiting pro-CO Zip, Mer, and Msh proteins to recombination sites, while the Mec1 kinase regulates CO distribution by a distinct mechanism. Moreover, CO formation and its control are implemented in a chromosome-specific manner, which may reflect a role for chromosome size in regulation.
Congenital Heart Disease and Autism: A Case-Control Study
Authors: Sigmon Eric R. , Kelleman Michael , Susi Apryl , Nylund Cade M. , Oster Matthew E.
Published: October 2019

OBJECTIVES:

There has long been an association between congenital heart disease (CHD) and general neurodevelopmental delays. However, the association between CHD and autism spectrum disorders (AuSDs) is less well understood. Using administrative data, we sought to determine the association between CHD and AuSD and identify specific CHD lesions with higher odds of developing AuSD.

METHODS:

We performed a 1:3 case-control study of children enrolled in the US Military Health System from 2001 to 2013. Children with International Classification of Disease, Ninth Revision, Clinical Modification codes for AuSD were identified as cases and matched with controls on the basis of date of birth, sex, and enrollment time frame. Each child’s records were reviewed for CHD lesions and associated procedures. Conditional logistic regression determined odds ratios (ORs) and 95% confidence intervals (CIs) for comparative associations.

RESULTS:

There were 8760 cases with AuSD and 26 280 controls included in the study. After adjustment for genetic syndrome, maternal age, gestational diabetes, short gestation, newborn epilepsy, birth asphyxia, and low birth weight, there were increased odds of AuSD in patients with CHD (OR 1.32; 95% CI 1.10–1.59). Specific lesions with significant OR included atrial septal defects (n = 82; OR 1.72; 95% CI 1.07–2.74) and ventricular septal defects (n = 193; OR 1.65; 95% CI 1.21–2.25).

CONCLUSIONS:

Children with CHD have increased odds of developing AuSD. Specific lesions associated with increased risk include atrial septal defects and ventricular septal defects. These findings will be useful for counseling parents of children with CHD.
Condiciones de movilidad en colonias marginadas. Unidad territorial Atlixcáyotl, Puebla
Authors: Guevara Romero Maria Lourdes , Ramírez-Rosete Norma Leticia
Published: October 2019

Los patrones tradicionales de segregación espacial en las ciudades de México han cambiado como consecuencia de la expansión de conjuntos habitacionales cerrados y de la aparición de centros comerciales en zonas de alto estatus. Un ejemplo de ello en la ciudad de Puebla se encuentra en la Unidad Territorial Atlixcáyotl, donde la política del uso del suelo ha entrelazado las fuerzas del mercado inmobiliario con las condiciones de pobreza y exclusión urbana en colonias como San Miguel la Rosa. El artículo analiza las condiciones actuales de movilidad y accesibilidad en dicha colonia y propone varias estrategias para mejorar esas condiciones, como base para un modelo de movilidad urbana sustentable de inclusión social.
Construcción experta del espacio vivido en Medellín. Caso Parques del Río
Authors: Vásquez González Juan Camilo , Andrade-Rivas Federico
Published: October 2019

Las transformaciones urbanas requieren de conocimientos que provienen de diferentes disciplinas, sin embargo, en la práctica, muchos de esos proyectos sólo tienen en cuenta la experticia técnica y desvirtúa el conocimiento construido por los habitantes de la ciudad. Este artículo hace uso de la triplicidad espacial propuesta por Henri Lefebvre para comprender y analizar los procesos observados en el megaproyecto Parques del Río Medellín. Para tal fin, se contrastó la teoría y la práctica entre aquellos que conciben el espacio y aquellos que lo viven, para explorar el desequilibrio de poder en que se encuentran los ciudadanos al momento de tomar decisiones frente a la planeación de la ciudad. El resultado de este estudio permitió percibir una colonización del espacio vivido y la puesta en marcha de una visión única del espacio urbano.
Entre luchas gremiales y modelos internacionales (1920-1947). El discurso sobre el urbanismo en Colombia
Authors: Botti Giaime
Published: October 2019

El artículo propone una lectura del proceso de construcción del discurso sobre el urbanismo en Colombia en la primera mitad del siglo XX. A partir de numerosas fuentes hemerográficas, se analiza el debate sobre la introducción del urbanismo como un saber especializado y autónomo en el país, y las luchas gremiales que se desarrollaron a raíz de este proceso. Lo anterior se complementa con la identificación de los modelos internacionales de referencia debatidos localmente, primero, en las publicaciones periódicas especializadas y, luego, en la Facultad de Arquitectura de la Universidad Nacional de Colombia, sede Bogotá. Con una mirada atenta a la circulación de ideas, imaginarios y expertos entre América Latina, Europa y Estados Unidos, este texto muestra los tiempos, la recepción, el papel específico de los actores y los espacios editoriales involucrados, así como las alianzas inesperadas y efímeras que se construyen en un marco profesional conflictivo.
Evaluación de la habitabilidad en barrios. Uso de técnicas alternativas
Authors: León Rodríguez Adriana Del Pilar , Alfonso Ávila Julieth Viviana , Díaz Márquez Sonia Esperanza , Quevedo Reyes Jorge Enrique
Published: October 2019

En la planificación de una ciudad se debe garantizar el diseño de barrios habitables, que cuenten con una jerarquización vial ordenada, zonas verdes suficientes y un espacio público adecuado, permitiendo la integración con las demás actividades de la ciudad. Sin embargo, cuando el barrio ya está construido, la acción del planificador se dirige a determinar su nivel de habitabilidad para establecer las necesidades de intervención. Así, el propósito de este artículo es evaluar la habitabilidad de barrios, considerando indicadores de movilidad y urbanismo, por medio del uso de técnicas no tradicionales en la ingeniería de transporte como la cartografía social, la observación aérea y una aplicación móvil (Mobydick). Para ello, se tomó como caso de estudio el barrio Asís en Tunja (Colombia). Como resultado, se evidenció que el uso simultáneo de técnicas interdisciplinarias complementa la evaluación de habitabilidad en una unidad funcional como el barrio, desde el punto de vista de la movilidad.
Formas de mobilidade, visibilidade e poder em Medellín: Metrocable e Parques- Biblioteca
Authors: Capillé Cauê , Reiss Camille
Published: October 2019

As renovações urbanas de Medellín tornaram-se modelo para a América Latina. O projeto integrado de transporte complementar ao metrô (em especial, os teleféricos) e de novos equipamentos culturais (em especial, bibliotecas públicas) abriu espaço para permitiu a atuação do Estado na melhoria da qualidade de vida nas áreas informais da cidade. No entanto, ao centralizar a gestão da mobilidade por intermédio de grandes infraestruturas de escala urbana, observa-se que os sistemas auto-organizacionais existentes são gradativamente substituídos ou sobrepostos pelo projeto estatal de renovação. É, portanto, importante compreender que esta nova “presença” (espacial e institucional) do Estado implica na modificação de sistemas de poder locais, para além da possibilidade de mobilidade urbana e acesso a serviços públicos. Este artigo analisa as culturas espaciais e territoriais dos Metrocables e dos Parques-Biblioteca. Discute, por fim, como essas culturas espaciais de  acesso e domínio visual ao/do território urbano implicam em diferentes formas de poder na cidade.
Medidas básicas de accesibilidad territorial. Enfoques, evolución y utilidades
Authors: López-Escolano Carlos , Pueyo Campos Ángel
Published: October 2019

Evaluar las relaciones entre las infraestructuras de transporte y el territorio es una tarea compleja debido a los múltiples factores que intervienen en ello, siendo la cuantificación de la accesibilidad uno de los instrumentos básicos para su análisis. Ante el creciente interés que presenta la accesibilidad para la planificación del territorio, las aportaciones en este campo son numerosas y diversas, enriqueciendo los discursos conceptuales y prácticos. Este trabajo valora el papel de la medida de la accesibilidad en los estudios territoriales mediante la revisión y puesta en común de los enfoques conceptuales principales desde una perspectiva geográfica, comparando medidas e indicadores básicos que se han formulado para su valoración. Como conclusión, cabe valorar la medida de la accesibilidad territorial como instrumento imprescindible para estudios territoriales a diferentes escalas gracias a sus múltiples utilidades y como herramienta de apoyo para la toma de decisiones en el diseño de la planificación territorial.
La regeneración urbana implementada en Guayaquil y Barcelona. Desvelando la retórica proyectual del espacio público
Authors: Navas Perrone María Gabriela
Published: October 2019

La construcción de espacios públicos es estratégica para la gobernanza urbana, ya que crea símbolos de legitimidad política, a la vez que concreta el objetivo de rentabilidad económica. Su promoción es avalada por un discurso compartido entre gobernantes, promotores y arquitectos, orientado a enaltecer las cualidades del espacio público como lugar destinado a la ciudadanía, y a ocultar la privatización de las plusvalías e implementación de políticas de control para regular la sociabilidad urbana. Evidenciar lo que opera detrás de esta retórica implica develar la etapa de concepción del Malecón 2000 de Guayaquil y de la Vila Olímpica de Barcelona, desde donde es susceptible identificar el constructo institucional que determinó la configuración del entorno construido. La ejecución de ambos proyectos se dio bajo un modelo de gestión urbana empresarial, lo que ratifica el fundamento del espacio público como un producto ideológico al servicio de la reapropiación capitalista de la ciudad.
Los Juegos Suramericanos, Medellín 2010: efectos y transformaciones territoriales
Authors: Giraldo Giraldo Diana Carolina
Published: October 2019

El artículo plantea una discusión en torno a los efectos y transformaciones territoriales derivados de los IX Juegos Suramericanos realizados en la ciudad de Medellín en el año 2010 y su relación con el desarrollo urbano, las acciones de gobernanza empresarial de la ciudad, las estrategias que se circunscribe para la producción globalizada del espacio y la experiencia territorial. Describe cómo el legado de este megaevento suscitó la modificación de los usos socioespaciales en la Unidad Deportiva Atanasio Girardot, afectando la experiencia vital de un grupo de vendedores que hicieron parte de la configuración de la identidad territorial y deportiva de este sector de la ciudad. Para ello,se recuperaron los relatos de los organizadores del evento, vendedores del área y usuarios, y se analizó la documentación oficial, problematizándola desde la geografía crítica y la sociología del deporte.
Lope de Vega. Las bodas entre el Alma y el Amor Divino. El hijo pródigo. Edición de J. Enrique Duarte. Kassel: Reichenberger, 2017, 282 páginas
Authors: Chen Sham Jorge
Published: October 2019

Lope de Vega. Las bodas entre el Alma y el Amor Divino. El hijo pródigo. Edición de J. Enrique Duarte. Kassel: Reichenberger, 2017, 282 páginas
Relationships between milk yield, quality and coagulation properties with kappa-casein (к-CN) genotypes of Bulgarian Rhodope cattle breed
Authors: Mehandzhiyski I. , Angelova Т. , Yordanova D. , Krastanov J.
Published: October 2019

Abstract. The aim of the present study was to establish the association between different к-CN genotypes with milk yield, quality and coagulation properties in dairy cows of Bulgarian Rhodope breed. For determination of milk proteins polymorphism and its relationship with individual coagulation properties of milk and its quality, 136 milk samples from Bulgarian Rhodope dairy cows reared in 4 farms were collected. The visit to the farms and the taking of the milk samples took place between May and June 2009. Animal milk is based on daily milking on the relevant control day of the current lactation. During the morning milking, 50mL samples were collected without preservative, stored in cooling bags and analyzed in the specialized lab at the Agricultural Institute, Stara Zagora by Computerized Renneting Metter. The evaluated parameters of milk coagulation properties were: rennet coagulation time (RCT, min); curd firming time (K20, min) and curd firmness (A30, mm). Milk proteins polymorphism was identified by tissue samples collection from 136 cows. To this end, specialized pliers and marks with a vial containing desiccant were used. With this technique, the tissue sample is obtained and sealed at the time of identification of the animal. After collection, tissue samples were shipped to the University in Padova, Italy for PCR-RFLP analysis. DNA was purified using a Maxwell®16 Tissue DNA purification kit (Promega) according to the manufacturer’s instructions. Data were analyzed using descriptive statistical analysis (SYSTAT 13). The results obtained give reason to the following conclusions: The highest milk yield was established in cows from the AH genotype – 16kg, whereas the lowest value was detected in cows from the BH genotype – 12.83kg. Homozygous cows from the BB genotype produced milk with the highest fat content – 5.11%, whereas heterozygous from the BH genotype: milk with the lowest protein content – 3.16%. The cows from the AH genotypes were outlined with the lowest milk fat and protein content. The longest rennet coagulation time (RCT) was observed in АА and АН genotypes, the longest curd firming time (К20) – in genotype AH, the highest curd firmness (А30) – in the milk of cows from the AB and BB genotypes.
Generative development of carrots (Daucus carota L.) during seed production depending on the fertilization
Authors: Trayanov Al.
Published: October 2019

Abstract. The main aim of the present study was to establish the changes in the generative development of carrots seed stalk during seed production depending on the frequency and level of fertilization. Two times of fertilization were tested: once – phosphorus and potassium were applied in autumn and nitrogen in transplanting time, and twice – half of phosphorus and potassium in the autumn, while the other half and nitrogen in soil in spring and half nitrogen in flowering. The number of umbels in the branches of I, II and III orders was determined. The average number of constituent units of one umbel from the central umbel and from umbels of different orders, as well as the average number of flowers in one umbel were established. Differences between variants were identified. Fertilization has a significant impact on the number of umbels and flowers. The number of flowers in the central umbel and those of the other umbels was the highest in one-time fertilization with N90P90K200/ha, while in two-times – with N50P190K200/ha.
Cooperative case studies from three countries: Is membership a problem or a solution in the 21st century?
Authors: Kispál-Vitai Zsuzsanna , Regnard Yann , Kövesi Klara , Guillotte Claude-André
Published: October 2019

The operations of the cooperative organization are an actively debated issue. The efficiency and viability of this organizational form still pose many unanswered questions. The literature is not unequivocal in evaluating the merits and drawbacks of this organization. This article provides empirical evidence from research about cooperatives covering three countries (Canada, France and Hungary) and tests theoretical hypotheses in the framework of organizational economics and cooperative theory. The findings point towards the positive influence of the social environment and cooperative values on organizational choice. The results prove the continued relevance of this type of organization in the 21st century in agriculture in all three researched countries.
Efeito do treinamento com flauta doce na força muscular respiratória de idosas: estudo piloto
Authors: Viana Dayane Aparecida , Vicentini de Oliveira Daniel , Sousa Perogari Maycon , Alves Silva Lilane Maria , Ruas Gualberto , Patrizzi Lislei Jorge , Ribeiro Luiz Gonçalves Jurema
Published: October 2019

Objetivo: O objetivo deste estudo foi mensurar a força muscular respiratória de idosas com treinamento com flauta doce. Métodos: Estudo quasi-experimental realizado com cinco idosas. As idosas foram submetidas a oito semanas de treinamento presenciais de 90 minutos com flauta doce referente a música “Noite Feliz”. A mensuração da força muscular respiratória foi realizada antes e após o período de treinamento, por meio de um manovacuômetro e a função respiratória por meio da espirometria. Utilizou-se a estatística descritiva e inferencial, considerando p<0,05. Resultados: A prova de função pulmonar não apresentou nenhuma alteração, com média de CVF, VEF1, VEF1/CVF (80±5, 82±5 e 89±6 %, respectivamente).  No entanto, a PImáx e a PEmáx apresentaram aumentos significantemente após o treinamento (54±20 vs 98±8 cmH2O, p<0,04 e 40±14 vs 68±17 cmH2O, p<0,03 respectivamente). Conclusão: Houve aumento da força muscular respiratório de idosas submetidas a um treinamento com flauta doce.
Endocrine-Related Adverse Events Related to Immune Checkpoint Inhibitors: Proposed Algorithms for Management
Authors: Del Rivero Jaydira , Cordes Lisa M. , Klubo-Gwiezdzinska Joanna , Madan Ravi A. , Nieman Lynnette K. , Gulley James L.
Published: October 2019

Immune checkpoint inhibitors have proven to be effective for various advanced neoplasia. Immune-related adverse events (irAEs) as a result of increased T cell activation are unique and potentially life-threating toxicities associated with the use of immune checkpoint inhibitors. Multiple endocrine irAEs, including primary hyperthyroidism and hypothyroidism, thyroiditis, primary adrenal insufficiency, type 1 diabetes mellitus, and hypophysitis, have been reported with the use of various immune checkpoint inhibitors. In some cases, these irAEs can lead to discontinuation of treatment. Here we propose for the general oncologist algorithms for managing endocrine irAEs to aid in the clinical care of patients receiving immunotherapy.

Key Points

There is a relative high risk of endocrine immune-related adverse events (irAEs) during therapy with checkpoint inhibitors, particularly when combination therapy is implemented. Patients treated with anti-CTLA-4 antibodies have an increased risk of hypophysitis, whereas patients treated with anti-PD-1/PD-L1 antibodies have a higher risk of primary thyroid dysfunction. Rarely, patients develop T1DM and central diabetes insipidus, and hypoparathyroidism is a rare occurrence. A growing clinical understanding of endocrine irAEs has led to effective treatment strategies with hormone replacement.
A Large, Multicenter, Retrospective Study on Efficacy and Safety of Stereotactic Body Radiotherapy (SBRT) in Oligometastatic Ovarian Cancer (MITO RT1 Study): A Collaboration of MITO, AIRO GYN, and MaNGO Groups
Authors: Macchia Gabriella , Lazzari Roberta , Colombo Nicoletta , Laliscia Concetta , Capelli Giovanni , D'Agostino Giuseppe Roberto , Deodato Francesco , Maranzano Ernesto , Ippolito Edy , Ronchi Sara , Paiar Fabiola , Scorsetti Marta , Cilla Savino , Ingargiola Rossana , Huscher Alessandra , Cerrotta Anna Maria , Fodor Andrei , Vicenzi Lisa , Russo Donatella , Borghesi Simona , Perrucci Elisabetta , Pignata Sandro , Aristei Cynthia , Morganti Alessio Giuseppe , Scambia Giovanni , Valentini Vincenzo , Jereczek-Fossa Barbara Alicja , Ferrandina Gabriella
Published: October 2019

Background

Recent studies have reported improvement of outcomes (progression-free survival, overall survival, and prolongation of androgen deprivation treatment-free survival) with stereotactic body radiotherapy (SBRT) in non-small cell lung cancer and prostate cancer. The aim of this retrospective, multicenter study (MITO RT-01) was to define activity and safety of SBRT in a very large, real-world data set of patients with metastatic, persistent, and recurrent ovarian cancer (MPR-OC).

Materials and Methods

The endpoints of the study were the rate of complete response (CR) to SBRT and the 24-month actuarial local control (LC) rate on “per-lesion” basis. The secondary endpoints were acute and late toxicities and the 24-month actuarial late toxicity-free survival. Objective response rate (ORR) included CR and partial response (PR). Clinical benefit (CB) included ORR and stable disease (SD). Toxicity was evaluated by the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC) and Common Terminology Criteria for Adverse Events (CTCAE) scales, according to center policy. Logistic and Cox regression were used for the uni- and multivariate analysis of factors predicting clinical CR and actuarial outcomes.

Results

CR, PR, and SD were observed in 291 (65.2%), 106 (23.8%), and 33 (7.4%) lesions, giving a rate of CB of 96.4%. Patient aged ≤60 years, planning target volume (PTV) ≤18 cm3, lymph node disease, and biologically effective dose α/β10 > 70 Gy were associated with higher chance of CR in the multivariate analysis. With a median follow-up of 22 months (range, 3–120), the 24-month actuarial LC rate was 81.9%. Achievement of CR and total dose >25 Gy were associated with better LC rate in the multivariate analysis. Mild toxicity was experienced in 54 (20.7%) patients; of 63 side effects, 48 were grade 1, and 15 were grade 2. The 24-month late toxicity-free survival rate was 95.1%.

Conclusions

This study confirms the activity and safety of SBRT in patients with MPR-OC and identifies clinical and treatment parameters able to predict CR and LC rate.
Solidification and stabilisation of metal plating sludge with fly ash geopolymers
Authors: Changjutturas Kosawat , Hoy Menglim , Rashid Ahmad Safuan A , Horpibulsuk Suksun , Arulrajah Arul
Published: October 2019

The disposal of metal plating sludge (PS) to landfills is an increasingly common practice in developed and developing countries. This paper presents a novel PS stabilisation technique using fly ash (FA)-based geopolymers as a waste management option. Strength and microstructural evaluations were carried out on PS-FA geopolymers at various values of factors, including liquid alkaline activator (L = sodium silicate (Na2SiO3)/sodium hydroxide (NaOH) ratio), L/FA ratios, FA/PS ratios and curing time. Increasing the amount of PS in PS-FA geopolymers reduced the total porosity, subsequently resulting in higher unconfined compressive strength (UCS) values. The main geopolymerisation product of the FA-based geopolymer was sodium aluminosilicate hydrate (N-A-S-H) gel. Since PS had a high calcium content, it would react with the high amount of silica and alumina present in FA to generate calcium aluminosilicate hydrate (C-A-S-H) gel in PS-FA geopolymers. This C-A-S-H gel coexisted with the N-A-S-H gel from FA-based geopolymers and hence significantly accelerated UCS development of PS-FA geopolymers over time. The UCS values of PS-FA geopolymers were found to meet the US Environmental Protection Agency requirement for disposal to landfills. The outcomes from this research can be translated into a regulatory framework for managing PS and diverting this industrial waste from landfills.
Stiffness parameters from cone pressuremeter tests at Changi East, Singapore
Authors: Soe Moe Kyaw Win , Bo Myint Win , Arulrajah Arul , Horpibulsuk Suksun , Hoy Menglim
Published: October 2019

A large-scale land reclamation project was carried out in the eastern part of Singapore involving 2000 hectares of land at a foreshore location from 1991 to 2005. The land was reclaimed, by placing sand hydraulically on the seabed comprising soft marine clay. Prefabricated vertical drains with surcharge preloading and deep compaction techniques, were used to improve the soft marine clay and reclaimed sand fill. Several specialist in situ tests were conducted during the project, such as with the cone penetration test (CPT), cone pressuremeter test (CPMT), dilatometer test and self-boring pressuremeter tests. The CPMT is an in situ testing method used to measure both the soil strength and stiffness parameters. The CPMT combines the advantages of a conventional pressuremeter test and a CPT. The CPT provides a continuous profile of the soil by measuring the stress on the cone tip, the sleeve friction and the pore-water pressure. The CPMT enables the assessment of the soil strength and stiffness at selected depths. CPMT tests were conducted on both the reclaimed sand and underlying soft marine clay layers during the Changi East reclamation project.
A new bio-based fibre-reinforced polymer obtained from sheep wool short fibres and PLA
Authors: Aldas Carrasco Miguel Fernando , Rouault Nicolas Jérôme , Ferri Azor José Miguel , López-Martínez Juan , Samper Madrigal María Dolores
Published: October 2019

Within the cheese industry is used the milk of a specific species of sheep whose wool is not suitable for the fibre industry. Therefore, this fibre becomes a waste by-product. To take advantage of this waste, the formulation of a fibre-reinforced polymer based on a poly(lactic acid) (PLA) matrix plasticised with maleinised linseed oil (MLO) is proposed. The work began by evaluating the feasibility of four fibre-cleaning processes. Then, to study the composition and processing conditions of the material, a complete factorial design of experiment 22, improved with four centre-points, was considered. Afterwards, the mechanical and thermal properties of the formulations were assessed. The results showed that the most suitable washing method was the one similar to the industrial cleaning process. The reprocessing of the material increased its homogeneity due to an improvement in the fibre–matrix interface. The Pareto chart showed that there was no interaction between the wool content and the number of times the material was reprocessed. In general, the addition of sheep wool to a PLA/MLO matrix did not significantly modify the mechanical and thermal properties of the matrix. These results indicate a viable alternative to reduce the wool waste generated in the food industry by means of new bio-based material formulations.
Intelligent Campus Implementation For Smart Cities
Authors: CESUR Raşit , TORKUL Orhan , CEDİMOĞLU İsmail Hakkı , UÇAR Seda
Published: October 2019

Digital transformation has provided the
decision-making infrastructure needed to produce custom solutions for each
person. Traditional decision support systems have begun to evolve into
intelligent systems and mass customization has begun to be applied in many
areas of life, such as education, transportation, health, and production. In
order to achieve digital transformation in teaching, it is necessary not only
to focus on the teaching process but also to focus on environmental factors.
The provision of digital content and the performance of the student are carried
out in the digital environment with education technologies. It is aimed to
maintain sustainability of the environmental quality by following the digital
environment by means of digital transformation and to improve the teaching
processes with intelligent systems that will interfere immediately in emergency
situations.
Determination of Environmental Radiation in the Beach Sand of Tatvan, Ahlat and Adilcevaz
Authors: KARATEPE Şule , KULUÖZTÜRK Muhammed Fatih
Published: October 2019

The determination of radiation level
is important in living areas for human health. The aim of this study is to
determine environmental radiation in the beach sands of Tatvan, Ahlat and
Adilcevaz. Environmental gamma radiation and alpha-beta concentrations
determined for 15 different points. It has used portable gamma survey meter
which is NaI(TI) scintillation detector. Also, it has used portable alpha-beta
survey meter which consist of ZnS(Ag)
scintillator adhered to 0.25 cm (0.010 in) thick plastic scintillator.
Obtained results were compared with literature.
High-temperature thermostatistical properties of deformed quantum gas in two dimensions
Authors: ŞENAY Mustafa
Published: October 2019

In this
study, we focus on the high-temperature thermostatistical properties of the q-deformed gas model in two spatial
dimensions. Some important thermodynamical functions such as internal energy,
entropy, specific heat are calculated depending on deformation parameter q. Moreover, the first five deformed
virial coefficients in the equation of state of the model for two dimensions
are derived. Also, the results obtained in this work are compared with the
results of the undeformed gas model.
Wi-Fi and LTE-LAA coexistence problems, challenges and features in 5GHz unlicensed bandwidth
Authors: SULAİMANİ Maqsood , ARI Seçkin
Published: October 2019

The
demand for high data rate and stable Quality of Service (QoS) from cellular
networks’ subscribers is a huge challenge for cellular operators. To overcome
this issue (providing high data rate and stable QoS) it requires more
bandwidth. The lack of licensed bandwidth and also its high cost make it hard
for operators to overcome this issue. To find a fair solution and expand the
capacity of cellular networks, operators started deployment of Long Term
Evolution (LTE) in unlicensed bandwidth, exactly utilizing 5GHz unlicensed
bandwidth in small cell scenarios. The extension of LTE to the 5GHz unlicensed
bandwidth where it is already in used by Wi-Fi will create huge coexistence
problems between Wi-Fi and LTE. It results from that Wi-Fi and LTE have
different channel access mechanisms. This paper presents the channel access
mechanisms of Wi-Fi and LTE-Licensed Assisted Access (LTE-LAA), coexistence problems,
challenges, privileges, coexistence features of LTE and Wi-Fi and Finally, we
conducted the simulation for LAA based on Listen Before Talk (LBT) mechanism and Wi-Fi to find that how LAA with
LBT mechanism is friendly to the Wi-Fi networks when they share the same
bandwidth. The simulation results illustrate that LAA based on LBT channel
access mechanism by alone cannot bring a fair coexistence between these two
technologies, it needs further improvement.