bluuebunny/crossref_metadata_2025 huggingface dataset:
Dual Effect of ITO‐Interlayer on Inverted Top‐Illuminated Polymer Solar Cells: Wetting of Polyelectrolyte and Tuning of Cavity
Authors: Dong Wan Jae , Park Jae Yong , Ham Juyoung , Jung Gwan Ho , Lee Illhwan , Lee Jong‐Lam
Published: May 2016

Flexible inverted top‐illuminated polymer solar cells (IT‐PSCs) are fabricated by wetting of polyelectrolyte and designing a microcavity structure by laying an indium‐tin‐oxide (ITO) interlayer on top of an Ag reflector. The ITO‐coated Ag makes the surface hydrophilic, thereby improving wettability of polyethyleneimine (PEIE). This increased wettability of PEIE yields a reflective cathode with low work function of 3.73 eV. The ITO layer also tunes the light absorption spectrum in the active layer. Finite‐domain time‐difference simulation provides evidence that the ITO layer played a role in both the shift in resonant wavelength in the microcavity and confinement of the electric field to the active layer. Time‐dependent simulation suggests that the time to reach steady‐state light absorption is longer (6.6 fs) when a microcavity is present than when it is not present (3.8 fs); i.e., the microcavity increases light absorption in the active layer. The designed IT‐PSCs show a maximum photo‐conversion efficiency of 6.4% on plastic film and 6.1% on opaque copper foil; these are the highest values obtained by top‐illuminated PSCs on a metallic substrate. The IT‐PSCs have excellent mechanical flexibility and more stable in air than conventional normal structured devices.
Energy optimization of water supply system scheduling: Novel MINLP model and efficient global optimization algorithm
Authors: Shi Hanyu , You Fengqi
Published: May 2016

This article is concerned with global optimization of water supply system scheduling with pump operations to minimize total energy cost. The scheduling problem is first formulated as a non‐convex mixed‐integer nonlinear programming (MINLP) problem, accounting for flow rates in pipes, operation profiles of pumps, water levels of tanks, and customer demand. Binary variables denote on–off switch operations for pumps and flow directions in pipes, and nonlinear terms originate from characteristic functions for pumps and hydraulic functions for pipes. The proposed MINLP model is verified with EPANET, which is a leading software package for water distribution system modeling. We further develop a novel global optimization algorithm for solving the non‐convex MINLP problem. To demonstrate the applicability of the proposed model and the efficiency of the tailored global optimization algorithm, we present results of two case studies with up to 4 tanks, 5 pumps, 5 check valves, and 21 pipes. © 2016 American Institute of Chemical Engineers AIChE J, 62: 4277–4296, 2016
Next‐generation sequencing in systemic mastocytosis: Derivation of a mutation‐augmented clinical prognostic model for survival
Authors: Pardanani Animesh , Lasho Terra , Elala Yoseph , Wassie Emnet , Finke Christy , Reichard Kaaren K. , Chen Dong , Hanson Curtis A. , Ketterling Rhett P. , Tefferi Ayalew
Published: May 2016

In routine practice, the World Health Organization classification of systemic mastocytosis (SM) is also the de facto prognostic system; a core value is distinguishing indolent (ISM) from advanced SM (includes aggressive SM [ASM], SM with associated hematological neoplasm [SM‐AHN] and mast cell leukemia [MCL]). We sequenced 27 genes in 150 SM patients to identify mutations that could be integrated into a clinical‐molecular prognostic model for survival. Forty four patients (29%) had ISM, 25 (17%) ASM, 80 (53%) SM‐AHN and 1 (0.7%) MCL; overall KITD816V prevalence was 75%. In 87 patients, 148 non‐KIT mutations were detected; the most frequently mutated genes were TET2 (29%), ASXL1 (17%), and CBL (11%), with significantly higher mutation frequency in SM‐AHN > ASM > ISM (P < 0.0001). In advanced SM, ASXL1 and RUNX1 mutations were associated with inferior survival. In multivariate analysis, age > 60 years (HR = 2.4), hemoglobin < 10 g/dL or transfusion‐dependence (HR = 1.7), platelet count < 150 × 109/L (HR = 3.2), serum albumin < 3.5 g/dL (HR = 2.6), and ASXL1 mutation (HR = 2.3) were associated with inferior survival. A mutation‐augmented prognostic scoring system (MAPSS) based on these parameters stratified advanced SM patients into high‐, intermediate‐, and low‐risk groups with median survival of 5, 21 and 86 months, respectively (P < 0.0001). These data should optimize risk‐stratification and treatment selection for advanced SM patients. Am. J. Hematol. 91:888–893, 2016. © 2016 Wiley Periodicals, Inc.
Changes in Ultrasonographic Vascularity Upon Initiation of Adalimumab Combination Therapy in Rheumatoid Arthritis Patients With an Inadequate Response to Methotrexate
Authors: Kaeley Gurjit S. , Nishio Midori J. , Goyal Janak R. , MacCarter Daryl K. , Wells Alvin F. , Chen Su , Kupper Hartmut , Kalabic Jasmina
Published: May 2016

Objective

To assess joint disease activity by ultrasound (US) in patients with rheumatoid arthritis (RA) initiating treatment with adalimumab (ADA) plus methotrexate (MTX).

Methods

Data for this post hoc analysis originated from the MUSICA trial (ClinicalTrials.gov identifier: NCT01185288), which evaluated the efficacy of initiating ADA (40 mg every other week) plus 7.5 or 20 mg/week MTX in 309 patients with RA with an inadequate response to MTX. Synovial vascularization over 24 weeks was assessed bilaterally at metacarpophalangeal joint 2 (MCP2), MCP3, MCP5, metatarsophalangeal joint 5, and the wrists by power Doppler US (PDUS). A semiquantitative 4‐grade scale was used. Disease activity was assessed using the Disease Activity Score in 28 joints using the C‐reactive protein level (DAS28‐CRP) and Simplified Disease Activity Index (SDAI). The correlation between continuous variables was assessed using Pearson's correlation coefficient.

Results

After 24 weeks of treatment with ADA plus MTX, rapid improvements in the mean synovial vascularity score were observed; the greatest improvements were in MCP2 (−0.5), MCP3 (−0.4), and the wrist (−0.4). At week 24, patients with the lowest DAS28‐CRP (<2.6) had the lowest mean 5‐joint and 3‐joint composite synovial vascularity scores. The 5‐joint and 3‐joint scores were strongly correlated (ρ > 0.9). Synovial vascularity scores correlated poorly with DAS28, swollen joint count in 66 joints (SJC66), SJC28, tender joint count in 68 joints (TJC68), TJC28, Clinical Disease Activity Index (CDAI), SDAI, physician's global assessment, patient's global assessment of pain, and disease duration (ρ < 0.2). Thirty‐two (70%) of 46 patients with a DAS28‐CRP of <2.6, and 11 (58%) of 19 patients with an SDAI indicating remission had at least 1 joint with a synovial vascularity score of ≥1.

Conclusion

PDUS detects changes in synovial vascularity in RA patients treated with ADA plus MTX, and residual synovial vascularity in patients in whom clinical disease control has been achieved.
A dual enzyme system composed of a polyester hydrolase and a carboxylesterase enhances the biocatalytic degradation of polyethylene terephthalate films
Authors: Barth Markus , Honak Annett , Oeser Thorsten , Wei Ren , Belisário‐Ferrari Matheus R. , Then Johannes , Schmidt Juliane , Zimmermann Wolfgang
Published: May 2016

TfCut2 from Thermobifida fusca KW3 and the metagenome‐derived LC‐cutinase are bacterial polyester hydrolases capable of efficiently degrading polyethylene terephthalate (PET) films. Since the enzymatic PET hydrolysis is inhibited by the degradation intermediate mono‐(2‐hydroxyethyl) terephthalate (MHET), a dual enzyme system consisting of a polyester hydrolase and the immobilized carboxylesterase TfCa from Thermobifida fusca KW3 was employed for the hydrolysis of PET films at 60°C. HPLC analysis of the reaction products obtained after 24 h of hydrolysis showed an increased amount of soluble products with a lower proportion of MHET in the presence of the immobilized TfCa. The results indicated a continuous hydrolysis of the inhibitory MHET by the immobilized TfCa and demonstrated its advantage as a second biocatalyst in combination with a polyester hydrolase for an efficient degradation oft PET films. The dual enzyme system with LC‐cutinase produced a 2.4‐fold higher amount of degradation products compared to TfCut2 after a reaction time of 24 h confirming the superior activity of his polyester hydrolase against PET films.
Improved production of N‐acetylglucosamine in Saccharomyces cerevisiae by reducing glycolytic flux
Authors: Lee Sang‐Woo , Oh Min‐Kyu
Published: May 2016

Glucosamine and its derivatives are utilized in the food and biomedical industries. However, current production relies on hydrolysis of natural sources, making it difficult to maintain quality and eliminate allergenic risk. Therefore, microbial production with aid of metabolic engineering is required. We previously demonstrated production of N‐acetylglucosamine (GlcNAc) in Saccharomyces cerevisiae by overexpressing an allosteric regulation‐free Gfa1p mutant and the haloacid dehalogenase‐like phosphatase YqaB. In this study, we further improved GlcNAc production by reducing glycolytic flux. Eukaryotic phosphofructokinase 1 (PFK‐1) is allosterically activated by fructose 2,6‐bisphosphate (F26BP). Disruption of PFK‐2, which synthesizes F26BP, resulted in a slight decrease of GlcNAc production and no significant change of glucose consumption and ethanol production. However, when galactose was used as a sole carbon source to the strain without PFK‐2, GlcNAc production was significantly increased and ethanol production was reduced, suggesting that further reduction of glycolytic flux can be used to further improve GlcNAc production. The methodology used in this study can be applied to improve production of carbohydrate derivatives in S. cerevisiae. Biotechnol. Bioeng. Biotechnol. Bioeng. 2016;113: 2524–2528. © 2016 Wiley Periodicals, Inc.
Metabolic engineering of Escherichia coli to produce 2′‐fucosyllactose via salvage pathway of guanosine 5′‐diphosphate (GDP)‐l‐fucose
Authors: Chin Young‐Wook , Seo Nari , Kim Jae‐Han , Seo Jin‐Ho
Published: May 2016

2′‐Fucosyllactose (2‐FL) is one of the key oligosaccharides in human milk. In the present study, the salvage guanosine 5′‐diphosphate (GDP)‐l‐fucose biosynthetic pathway from fucose was employed in engineered Escherichia coli BL21star(DE3) for efficient production of 2‐FL. Introduction of the fkp gene coding for fucokinase/GDP‐l‐fucose pyrophosphorylase (Fkp) from Bacteroides fragilis and the fucT2 gene encoding α‐1,2‐fucosyltransferase from Helicobacter pylori allows the engineered E. coli to produce 2‐FL from fucose, lactose and glycerol. To enhance the lactose flux to 2‐FL production, the attenuated, and deleted mutants of β‐galactosidase were employed. Moreover, the 2‐FL yield and productivity were further improved by deletion of the fucI‐fucK gene cluster coding for fucose isomerase (FucI) and fuculose kinase (FucK). Finally, fed‐batch fermentation of engineered E. coli BL21star(DE3) deleting lacZ and fucI‐fucK, and expressing fkp and fucT2 resulted in 23.1 g/L of extracellular concentration of 2‐FL and 0.39 g/L/h productivity. Biotechnol. Bioeng. 2016;113: 2443–2452. © 2016 Wiley Periodicals, Inc.
Mild Approach for Non‐Catalytic Hydrogenation of Liquid Natural Rubber Using 2,4,6‐Trimethylbenzenesulfonyl Hydrazide as the Diimide Source
Authors: Rasid Hamizah Md , Azhar Nur Hanis Adila , Jamaluddin Naharullah , Yusoff Siti Fairus M.
Published: May 2016

This article reports an efficient, mild‐temperature method for the hydrogenation of liquid natural rubber (LNR). The hydrogenation of LNR was studied using diimide generated in situ from the thermolysis of 2,4,6‐trimethylbenzenesulfonyl hydrazide (MSH) in o‐xylene at 100°C. The effects of reaction temperature, reaction time, solvent, and MSH/LNR weight ratio on the percentage of hydrogenation were evaluated.
1H NMR analysis revealed that ~80% hydrogenation was achieved with a weight ratio of MSH:LNR = 1:1 at 100°C in o‐xylene within 60 min.
Bioreduction of [Co(III)‐EDTA]− by Denitrifying Granular Sludge Biofilms
Authors: Reddy Gangidi Kiran Kumar , Nancharaiah Yarlagadda V. , Mohan Tulasi V. Krishna
Published: May 2016

Cobalt‐60 is a by‐product formed in the nuclear and defense‐related industries. Bioreduction of stable [Co(III)‐EDTA]− to the less stable [Co(II)‐EDTA]2− constitutes a bioremediation approach. Bioreduction of [Co(III)‐EDTA]− by a denitrifying microbial community was studied. Denitrifying granular sludge cultivated in a bioreactor exhibited efficient [Co(III)‐EDTA]− reduction. Fed‐batch experiments showed repeated reduction of [Co(III)‐EDTA]− without loss of microbial activity. Bioreduction of [Co(III)‐EDTA]− was accelerated in the presence of anthraquinone‐2,6‐disulfonate. Simultaneous reduction of both nitrate and [Co(III)‐EDTA]− was observed, but denitrification was delayed in the presence of [Co(III)‐EDTA]−. Microbial reduction in the presence of excess nitrate and acceleration by an electron shuttle has practical implications in cobalt bioremediation.
Phosphono Bisbenzguanidines as Irreversible Dipeptidomimetic Inhibitors and Activity‐Based Probes of Matriptase‐2
Authors: Häußler Daniela , Mangold Martin , Furtmann Norbert , Braune Annett , Blaut Michael , Bajorath Jürgen , Stirnberg Marit , Gütschow Michael
Published: May 2016

Matriptase‐2, a type II transmembrane serine protease, plays a key role in human iron homeostasis. Inhibition of matriptase‐2 is considered as an attractive strategy for the treatment of iron‐overload diseases, such as hemochromatosis and β‐thalassemia. In the present study, synthetic routes to nine dipeptidomimetic inactivators were developed. Five active compounds (41–45) were identified and characterized kinetically as irreversible inhibitors of matriptase‐2. In addition to a phosphonate warhead, these dipeptides possess two benzguanidine moieties as arginine mimetics to provide affinity for matriptase‐2 by binding to the S1 and S3/S4 subpockets, respectively. This binding mode was strongly supported by covalent docking analysis. Compounds 41–45 were obtained as mixtures of two diastereomers and were therefore separated into the single epimers. Compound 45 A, with S configuration at the N‐terminal amino acid and R configuration at the phosphonate carbon atom, was the most potent matriptase‐2 inactivator with a rate constant of inactivation of 2790 m−1 s−1 and abolished the activity of membrane‐bound matriptase‐2 on the surface of intact cells. Based on the chemotyp of phosphono bisbenzguanidines, the design and synthesis of a fluorescent probe (51 A) by insertion of a coumarin label is described. The in‐gel fluorescence detection of matriptase‐2 was demonstrated by applying 51 A as the first activity‐based probe for this enzyme.
ChemInform Abstract: Investigation of the Surface Properties of Tin‐Molybdenum Oxides by X‐Ray Photoelectron Spectroscopy.
Authors: BERRY F. J. , HALLETT C. , MARBROW R. A.
Published: May 2016

Sn‐Mo oxides formed by moderate temp. calcination adopt poorly crystalline rutile‐related structures.
ChemInform Abstract: Chemistry of Sulfur Halides. Part 18. Crystal Structure of Tribromosulfonium(IV)‐hexafluoroantimonate(V), SBr+ 3SbF‐ 6.
Authors: MINKWITZ R. , LEKIES R. , PREUT H.
Published: May 2016

The title compound, prepared as shown in the scheme, crystallizes in space group P212121 with Z=4, The structure shows short contacts between S and F atoms forming a distorted ψ‐octahedral coordination around the S atom.
ChemInform Abstract: 17O and 27Al NMR Spectroscopic Investigations of Aluminum(III) Hydrolysis Products.
Authors: THOMPSON A. R. , KUNWAR A. C. , GUTOWSKY H. S. , OLDFIELD E.
Published: May 2016

The results of 17O and 27Al NMR spectra of the products of Al(III) hydrolysis by base show the combined use of solution and solid‐state NMR techniques to permit determination of nuclear quadrupolar coupling constants (e2qQ/h, in solution and solid state) for both the nuclei, and in suitable cases, measurements of rotational correlation times in solution.
ChemInform Abstract: Surface Characterization of Zirconia After Reaction with Water
Authors: KAGAWA M. , OMORI M. , SYONO Y. , IMAMURA Y. , USUI S.
Published: May 2016

has been performed by electrophoretic mobility measurements.
ChemInform Abstract: Hydrogen Atom Abstraction from C‐H, P‐H, Si‐H, and Sn‐H Bonds by the Triplet Excited State of the Tetrakis(μ‐pyrophosphito)diplatinum(II) Tetraanion. Spectroscopic Observation of the Mixed‐Valence Hydride Complex Pt2(μ‐P2O5H2)4H4‐.
Authors: ROUNDHILL D. M. , ATHERTON S. J. , SHEN Z.‐P.
Published: May 2016

The Pt(II)Pt(III) hydride complex Pt2(μ‐P2O5H2)4H4‐ (I) can be generated by either pulse radiolysis of aqueous Pt2(μ‐P2O5H2)44‐ (II) at pH 4 in the presence of t‐BuOH or by pulsed‐laser photolysis (Nd‐YAG at 355 nm) or aqueous (II) with added i‐PrOH, H3PO3, or H3PO2.
ChemInform Abstract: Metal(II) Hexafluoroantimonates: Preparation and Characterization of MF2·2 SbF5 (M: Mg, Ni, Zn, Fe, Co, Cu, Cr, Ag, Cd, or Pb) and the X‐Ray Structure Determination of AgF2·2 SbF5.
Authors: GANTAR D. , LEBAN I. , FRLEC B. , HOLLOWAY J. H.
Published: May 2016

The title adducts are prepared according to the scheme (no yields given).
ChemInform Abstract: A New Low‐Temperature Route to Metal Polychalcogenides: Solid‐State Synthesis of K4Ti3S14, a Novel One‐Dimensional Compound.
Authors: SUNSHINE S. A. , KANG D. , IBERS J. A.
Published: May 2016

The title compound has been obtained from the reaction of Ti with K2S and S powder in a sealed silica tube at 375 °C (50 h).
ChemInform Abstract: Preparation, Structure, and Magnetic Properties of New Form of Chromium Orthoarsenate: β‐CrAsO4.
Authors: ATTFIELD J. P. , CHEETHAM A. K. , JOHNSON D. C. , TORARDI C. C.
Published: May 2016

Light green needle‐shaped crystals of β‐CrAsO4 have been obtained at 700 °C under 3‐kbar hydrothermal pressure starting from Cr2O3 and a H3PO4 solution.
ChemInform Abstract: Pairwise Additivity in Exciton‐Coupled CD Curves of Multichromophoric Systems.
Authors: WIESLER W. T. , VAZQUEZ J. T. , NAKANISHI K.
Published: May 2016

All 24 permutational isomers of methyl α‐D‐glucopyranoside containing two acetates and two exciton chromophores (p‐bromobenzoate(s) and/or p‐methoxycinnamate(s)) such as (I) (six dicinnamates, six dibenzoates, and 12 monocinnamate monobenzoates) and 20 tri‐ and tetrachromophoric derivatives (all the six dibenzoate dicinnamates, the four monobenzoate tricinnamates and the four monocinnamate tribenzoates as well as the 6 trichromophoric monoacetates (II) and (III)) are prepared.
ChemInform Abstract: Long‐Distance Magnetic Exchange Between Chromium(III) Atoms Bridged by H3O‐ 2 Ligands.
Authors: ARDON M. , BINO A. , MICHELSEN K. , PEDERSEN E.
Published: May 2016

The magnetic susceptibilities of the known compound (I) and the complex (II), whose structure is established (space group P2/n, Z=2), are measured by the Faraday method at a field strength of 12000 Oe in the temp. range 1.7‐300 K. The data exhibit a decreasing magnetic moment at low temp., which is interpreted in terms of magnetic saturation at 13kG combined with antiferromagnetic coupling.
ChemInform Abstract: Electrochemical Formation of an Organic Thin Film by Disruption of Micelles.
Authors: HOSHINO K. , SAJI T.
Published: May 2016

When aqueous solutions of 2.0 mmol of (11‐ferrocenylundecyl)trimethylammonium bromide as surfactant, 39 μmol of 1‐phenylazo‐2‐naphthol (PAN) to be deposited, and 0.2 mol Li2SO4 are electrolyzed with controlled potential using indium tin oxide (ITO) electrodes, thin films of PAN are deposited on the ITO electrodes because of an electrooxidative breakdown of the micelles of the surfactant which solubilized the PAN, which now is supersaturated.
ChemInform Abstract: Rate Enhancement of Biomimetic Polyene Cyclizations by a Cation‐Stabilizing Auxiliary.
Authors: JOHNSON W. S. , LINDELL S. D. , STEELE J.
Published: May 2016

An enormous rate acceleration is disclosed in the cyclization of the polyene (VIIb) (→ (VIIIb)) with an isobutenyl group at pro‐C‐8 as a cation‐stabilizing auxiliary group vs.
ChemInform Abstract: Catalytic Asymmetric Epoxidation and Kinetic Resolution: Modified Procedures Including in situ Derivatization.
Authors: GAO Y. , HANSON R. M. , KLUNDER J. M. , KO S. Y. , MASAMUNE H. , SHARPLESS K. B.
Published: May 2016

The use of 3 Å or 4 Å molecular sieves (ms) substantially increases the scope of the Ti(IV)‐catalyzed asym.
ChemInform Abstract: Convenient Preparation of 1,3‐Bis(2,3,4,5‐tetramethylcyclopentadienyl)propane: Use of 2,3,4,5‐Tetramethylcyclopent‐2‐enone Enolate as a Synthetic Equivalent for the Tetramethylcyclopentadienyl Anion.
Authors: MINTZ E. A. , PANDO J. C. , ZERVOS I.
Published: May 2016

Treatment of the tetramethylcyclopentenone (I) with lithium diisopropylamide produces the enolate (II) which serves as a synthetic equivalent for the tetramethylcyclopentadienyl anion.
ChemInform Abstract: Mixed Methyl Silyl Ketals of Quinones: Their Preparation via Anodic Oxidation and Their Chemistry.
Authors: STERN A. , SWENTON J. S.
Published: May 2016

Anodic oxidation of the monosilylated hydroquinones (I) gives the quinone monoacetals (II).
ChemInform Abstract: Regiospecific Oxidation of Methyl Groups in Dimethylanisoles.
Authors: HAUSER F. M. , ELLENBERGER S. R.
Published: May 2016

The dimethylanisoles (I) are regiospecifically oxidized at one methyl group using copper(II) sulfate and peroxodisulfate to yield the aldehydes (II).
ChemInform Abstract: (3.3)Orthocyclophanes with Facing Benzene and Naphthalene Rings.
Authors: MATAKA S. , TAKAHASHI K. , MIMURA T. , HIROTA T. , TAKUMA K. , KOBAYASHI H. , TASHIRO M. , IMADA K. , KUNIYOSHI M.
Published: May 2016

The unsymmetrically substituted bicyclic ketone (Vc) is synthesized as outlined in the reaction scheme.
ChemInform Abstract: Synthesis and X‐Ray Structural Analysis of a Five‐Membered Building Block.
Authors: KUNSTMANN R. , PAULUS E. F.
Published: May 2016

In connection with studies on the synthesis of prostaglandin analogues the 3a‐RS‐4‐RS‐5‐RS‐6a‐RS bicyclic acid (V) is prepared.
ChemInform Abstract: β‐Stannyl Enones as Radical Traps: A Very Direct Route to PGF2α.
Authors: KECK G. E. , BURNETT D. A.
Published: May 2016

Radical‐induced reaction of the β‐stannyl enone (III) with the iodo acetals (VI) and (VIII) gives the enones (VII) and (IX) via a so‐called cyclization‐trapping sequence.
ChemInform Abstract: Palladium‐Catalyzed Coupling of Oxazol‐2‐yl‐ and 2‐Oxazolin‐2‐yltrimethylstannes with Aromatic Halides. A New Entry to 2‐Aryl‐ and 2‐Heteroaryloxazoles and ‐oxazolines.
Authors: DONDONI A. , FANTIN G. , FOGAGNOLO M. , MEDICI A. , PEDRINI P.
Published: May 2016

4‐Methyloxazole (I) and 4,4‐dimethyl‐2‐oxazoline (VI) are converted to the 2‐trimethylstannyl derivatives (III) and (VII) by sequential treatment with butyllithium and trimethyltin chloride (II).
ChemInform Abstract: 2‐Substituted‐5‐Chloro/Nitrobenzophenones as Possible Anticonvulsants.
Authors: KULKARNI Y. D. , SHARMA R. , SHARMA V. L. , DUA P. R.
Published: May 2016

The 2‐amino or 2‐hydroxybenzophenones (I) are coupled with the arylthiocyanates (II) to produce the thiocarbamates or thioureas (III).
ChemInform Abstract: Reaction of an Iodonium Ylide with Methanesulfonyl Chloride.
Authors: HANEFELD W. , SPANGENBERG B.
Published: May 2016

The reaction of iodosylbenzene diacetate (II) with the 1,3‐dicarbonyl compounds (I) is investigated: the 1,3‐propanedione (Ia) and (II) produce the phenyliodonium ylide (III) which is converted to the 1,2,3‐ trione (IV) by means of ozonolysis.
ChemInform Abstract: Polyfunctionally Substituted Pyridines from Cyanoacetamide and Cyanoacetanilide.
Authors: MOHAREB R. M. , HABASHI A. , SHAMS H. Z. , FAHMY S. M.
Published: May 2016

The (diaminodicyanopyridyl)acetamides (III) are prepared by three different methods as outlined in the reaction scheme.
ChemInform Abstract: Studies on Quinoline and Phenothiazine. Preparation and Antimicrobial Activity of 2‐Morpholino‐4‐(8′‐oxyquinolino)‐6‐phenylurea‐s‐triazine and 1,3,7,9‐Tetrachloro‐10‐(acetylphenylurea)phenothiazine.
Authors: DESAI K. R. , KAPADIA S. K.
Published: May 2016

The quinoline derivatives (VII) mentioned in the title are prepared from cyanuric chloride (I) by consecutive substitution of the chlorine atoms for morpholine (II), 8‐hydroxyquinoline (IV) and the phenylureas (VI).
ChemInform Abstract: Optical, Structural, and Chemical Characteristics of Lead‐Indium Phosphate and Lead‐Scandium Phosphate Glasses.
Authors: SALES B. C. , BOATNER L. A.
Published: May 2016

Among the oxides studied (e.g.
ChemInform Abstract: On the Reaction of N‐Vinyliminophosphorane. Part 5. The Formation of Pyridines or Pyrroles by the Reaction of N‐Vinyliminophosphoranes with α,β‐Unsaturated Ketones or α‐Bromo Ketones.
Authors: KOBAYASHI T. , IINO Y. , NITTA M.
Published: May 2016

The phenylvinyliminophosphoranes (III) are subjected to cycloaddition reactions with the α,β‐unsaturated carbonyl compounds (IV) or the α‐bromo carbonyl derivatives (IX): (III) and (IV) form the pyridines (V) or the regioisomer (VIII), the 1,5‐dicarbonyl compounds (VI) and acetophenone (VII).
ChemInform Abstract: Electronic Transitions of Polyacenequinone Radical Anions in the 1‐2 μm Region.
Authors: JOZEFIAK T. H. , MILLER L. L.
Published: May 2016

Compounds (I)‐(VI) (position of substituent tBu in (I) not defined) are reduced electrochemically (DMF, 0.1 (Bu4N)+‐BF4‐) and the anodic and cathodic peak potentials as well as the absorptions λmax, (log ε) of their semiquinones are tabulated.
ChemInform Abstract: A Study of Complex Formation Between Differently Charged Free‐Base Porphyrins and Samarium Porphyrins.
Authors: RADZKI S. , KRAUSZ P. , GASPARD S. , GIANNOTTI C.
Published: May 2016

The intramolecular interactions and complex formations between anionic, neutral and cationic free porphyrin bases (Ia)‐(Ic) and their Sm(III) complexes are investigated in DMSO by spectrophotometric methods.
ChemInform Abstract: Alkylation of Heteroaryl Halides by 2:1 Grignard Reagent/Cu(I) Mixtures. Synthesis of Alkylated Octahydrodibenzo(b,j)(1,10)phenanthrolines.
Authors: BELL T. W. , HU L.‐Y. , PATEL S. V.
Published: May 2016

1,2‐Diaminobenzene (I) and the cyclohexanonecarboxylate (II) are coupled and then cyclized to form the dibenzophenanthrenedione (III) which is converted to the chloro derivative (IV).
ChemInform Abstract: Synthesis and Structure of Carboxylic Acid N‐Vinyl‐N‐alkylamides.
Authors: AKSENOV A. I. , KONDRAT'EV N. B. , DEMIDOVA N. V. , PROKOF'EV E. P. , OVSEPYAN A. M. , LAVUT E. E. , PANOV V. P. , KIRSH YU. E. , KOCHERGIN P. M.
Published: May 2016

Reaction of the Schiff bases (I) with the carboxylic anhydrides (II) yields the amides (III) mentioned in the title.
ChemInform Abstract: Studies in SRN1 Series. Part 19. A General SRN1‐Based Method for Total Synthesis of Unsymmetrically Hydroxylated 2,2′‐Binaphthalenes.
Authors: BEUGELMANS R. , BOIS‐CHOUSSY M. , TANG Q.
Published: May 2016

The binaphthalenes (V) mentioned in the title are prepared by photochemically induced coupling of the 2‐acetylnaphthalenes (I) with the o‐bromoacetophenones (II) via cyclization of the intermediate benzyl naphthyl ketones (III).
ChemInform Abstract: Diastereoselectivity in the Directed Aldol Condensation of 2‐Trimethylsiloxyfuran with Aldehydes. A Stereodivergent Route to threo and erythro δ‐Hydroxy‐γ‐lactones.
Authors: JEFFORD C. W. , JAGGI D. , BOUKOUVALAS J.
Published: May 2016

2‐Trimethylsiloxyfuran (I) is coupled with the aldehydes (II) to give mixtures of the diastereomeric alcohols (III).
ChemInform Abstract: Stereoselectivity During Intramolecular Nitrile Oxide Olefin Cycloadditions. Synthesis of Fused Azetidines.
Authors: HASSNER A. , MURTHY K. S. K.
Published: May 2016

The azetidine (II) is coupled with the nitroalkenes (I) to produce the N‐(2‐nitroethyl) derivatives (III).
ChemInform Abstract: Flash Vacuum Pyrolysis of α‐Toluenesulfonyl Azide.
Authors: ABRAMOVITCH R. A. , HARDER R. R. , HOLCOMB W. D.
Published: May 2016

Flash vacuum pyrolysis of the sulfonyl azide (I) leads to the formation of the pyridine (III), together with bibenzyl (II) and the benzisothiazole dioxide (IV).
ChemInform Abstract: Synthesis and β‐Lactamase Inhibitory Properties of 2β‐((1,2,3‐Triazol‐ 1‐yl)methyl)‐2α‐methylpenam‐3α‐carboxylic Acid 1,1‐Dioxide and Related Triazolyl Derivatives.
Authors: MICETICH R. G. , MAITI S. N. , SPEVAK P. , HALL T. W. , YAMABE S. , ISHIDA N. , TANAKA M. , YAMAZAKI T. , NAKAI A. , OGAWA K.
Published: May 2016

Cycloaddition reaction between the azido group in (I) and the acetylenes (II) gives the title compounds (III) directly.
ChemInform Abstract: Inhibitors of Dopamine β‐Hydroxylase. Part 3. Some 1‐(Pyridylmethyl)imidazole‐2‐thiones.
Authors: ROSS S. T. , KRUSE L. I. , OHLSTEIN E. H. , ERICKSON R. W. , EZEKIEL M. , FLAIM K. E. , SAWYER J. L. , BERKOWITZ B. A.
Published: May 2016

Reaction of the pyridinecarboxaldehydes (I) with the acetal (II) forms imines as intermediates which are reduced to give the N‐substituted amino acetals (III).
ChemInform Abstract: Novel 2,2,6,6‐Tetrasubstituted 4‐Piperidones.
Authors: SOSNOVSKIKH V. YA. , KAT'YANOVA V. R.
Published: May 2016

The divinyl ketones (I) are cyclized with ammonia to give the title compounds (II).
ChemInform Abstract: Oxidation of Indoles with Pyridinium Bromide Perbromide. A Simple and Efficient Synthesis of 7‐Azaoxindoles.
Authors: MARFAT A. , CARTA M. P.
Published: May 2016

The indoles (Ia) ‐ (Ic) and the azaindole (Id) are treated with pyridinium bromide perbromide to form the dibromo(aza)oxindoles (II), together with the tribromides (III).
ChemInform Abstract: Synthesis of Pyrano(thiopyrano)(3,4‐c)pyridine and Pyrano(thiopyrano)‐(3,4‐c)pyran Derivatives.
Authors: PARONIKYAN E. G. , MIRZOYAN G. V. , NORAVYAN A. S. , VARTANYAN S. A.
Published: May 2016

The (thio)pyranylidenemalononitrile (I) reacts with phenyl isothiocyanate (II) to give the (thio)pyranopyridinethione (III) which is treated with hydrazine hydrate (IV), producing the hydrazinopyridines (V) by rearrangement.
ChemInform Abstract: Synthesis and Cardiotonic Activity of a Series of Substituted 4‐Alkyl‐ 2(1H)‐quinazolinones.
Authors: BANDURCO V. T. , SCHWENDER C. F. , BELL S. C. , COMBS D. W. , KANOJIA R. M. , LEVINE S. D. , MULVEY D. M. , APPOLLINA M. A. , REED M. S. , MALLOY E. A. , FALOTICO R. , MOORE J. B. JUN. , TOBIA A. J.
Published: May 2016

The synthesis of the 4‐methylquinazolinones (IIIa) and (IIIb) from the 2‐aminoacetophenones (I) is accomplished either directly by cyclization with potassium cyanate (II) or via conversion of (I) to the carbamate (V) and subsequent ring closure.
ChemInform Abstract: Synthesis of 7‐Thioxo‐4,5,7,8‐tetrahydro‐1,2,4‐triazolo(5,1‐c)(1,2,4)triazines.
Authors: HETZHEIM A. , SCHNEIDER D.
Published: May 2016

Reaction of the diaminodihydrotriazine (I) with the isothiocyanates (II) yields the thioxotriazolotriazines (III).
ChemInform Abstract: gem‐Diphosphonate and gem‐Phosphonate‐Phosphate Compounds with Specific High Density Lipoprotein Inducing Activity.
Authors: NGUYEN L. M. , NIESOR E. , BENTZEN C. L.
Published: May 2016

Reaction of the dimethyl acylphosphonates (I) with dimethyl phosphite (II) yields the hydroxydiphosphonates (III) or the phosphonate phosphates (IV) depending on the reaction conditions.
ChemInform Abstract: Reaction of Chloroacetylenephosphonates with Neutral Nucleophiles.
Authors: GARIBINA V. A. , LEONOV A. A. , DOGADINA A. V. , IONIN B. I. , PETROV A. A.
Published: May 2016

Reaction of the phosphonates (I) with the nucleophilic reagents (II), containing a primary amino group and a second nucleophilic centre, yields the phosphorylated benzimidazoles or benzoxazoles (III).
ChemInform Abstract: Synthesis of 2,6‐Diamino‐4‐pyridin‐3‐yl‐3,5‐dicyanoselenopyran and Its Recyclization to 6‐Amino‐4‐pyridin‐3‐yl‐3,5‐dicyano‐2(1H)‐pyridineselenone.
Authors: SHARANIN YU. A. , DYACHENKO V. D.
Published: May 2016

The selenopyrane (III) is formed on treatment of the pyridine derivative (I) with cyanoselenoacetamide (II) in the presence of N‐methylmorpholine.
ChemInform Abstract: Synthesis of Bile Pigments. Part 14. Synthesis of a Bilindionostilbenoparacyclophane as a Model for “Stretched” Bile Pigment Chromophores of Biliproteins.
Authors: NESVADBA P. , GOSSAUER A.
Published: May 2016

To test if there is a relationship between conformation of bile pigment molecules and their spectroscopic properties, the (Z)‐paracyclophane (IIIb) is prepared as given in the scheme (substituent ‐Oct exclusively to increase solubility).
ChemInform Abstract: Asymmetric Alkylation of Chiral β‐Lactam Ester Enolates. A New Approach to the Synthesis of α‐Alkylated α‐Amino Acids.
Authors: OJIMA I. , QIU X.
Published: May 2016

Asym. alkylation of the β‐lactam enolate generated from (I) yields the lactam esters (III), which are converted to the dipeptide derivatives (IV) with high optical purities in excellent yields.
ChemInform Abstract: Use of the Allyloxycarbonyl Protective Group in Carbohydrate Chemistry.
Authors: BOULLANGER P. , CHATELARD P. , DESCOTES G. , KLOOSTERMAN M. , VAN BOOM J. H.
Published: May 2016

Treatment of the sugar derivatives (I), (IVa), and (Va) with allyl chloroformate (III) yields the corresponding allyloxycarbonylated compounds (II), (IVb), and (Vb).
ChemInform Abstract: Stereoselectivity in the Hydroboration of C4‐C‐Methylene Groups.
Authors: MOLINO B. F. , CUSMANO J. , MOOTOO D. R. , FAGHIH R. , FRASER‐REID B.
Published: May 2016

The 4‐methylenepyranosides (IV) are prepared by consecutive Swern oxidation and Wittig olefination of the alcohols (I).
ChemInform Abstract: Stereochemical Assignment of the threo and erythro Forms of 2‐(2,6‐Dimethoxyphenoxy)‐1‐(3,4‐dimethoxyphenyl)‐1,3‐propanediol from X‐Ray Analyses of the Synthetic Intermediates (Z)‐2‐(2,6‐Dimethoxyphenoxy)‐3‐(3,4‐dimethoxyphenyl)‐2‐propenoic Acid and threo‐2‐(2,6‐Dimethoxyphenoxy)‐3‐(3,4‐dimethoxyphenyl)‐3‐hydroxypropanoic Acid.
Authors: LUNDQUIST K. , STOMBERG R. , VON UNGE S.
Published: May 2016

The structure of the title diols (IV) (no yields given) is determined by X‐ray analysis of their precursors (III) and (V) (space groups P21/c and C2/c with Z=4 and Z = 8, resp.).
ChemInform Abstract: Some New Examples of Phases with Sheets of MX8 Square Antiprisms or MX9 Polyhedra.
Authors: MIKOU A. , LAVALI J. P. , FRIT B.
Published: May 2016

BaM6F22O2 (I), BaM6F24O (II) (M: Th, U), BaU5LnF25, (Ln: lanthanoids, Y) (III), and PbZr3F6O4 (IV) have been prepared by solid state reactions of the corresponding binary fluorides and oxides, respectively.
ChemInform Abstract: Nature of Carbon‐Lithium Bonding in Dilithiated Polynuclear Aromatics: An MNDO Study
Authors: SYGULA A. , LIPKOWITZ K. , RABIDEAU P. W.
Published: May 2016

(nonsym.
ChemInform Abstract: Kinetics and Mechanism of Oxidative Dehydrogenation of Ethane and Small Alkanes with Nitrous Oxide over Cobalt‐Doped Magnesium Oxide.
Authors: AIKA K. , ISOBE M. , KIDO K. , MORIYAMA T. , ONISHI T.
Published: May 2016

Pure alkanes from C1 to C4 react at much the same rate with N2O (mainly at 473 K, below atmospheric pressure, over Co2+‐doped MgO catalysts), because the decomposition of N2O is the rate‐determining step.
ChemInform Abstract: Mono‐ and Bis(aryl/alkylthio)butenynes, Bis‐ and Tris(aryl/alkylthio)butadienes from Pentachlorobutadiene and Hexachlorobutene.
Authors: IBIS C.
Published: May 2016

The reaction of the pentachlorobutadiene (II) with the thiols (I) or (VIII) affords the various products (III)‐(XI) shown in the scheme.
ChemInform Abstract: Reaction of Splitting of Perhydrothieno(3,4‐d)oxazolethione‐5,5‐dioxides.
Authors: PETRUKHAN V. I. , KHASKIN G. I. , BEZMENOVA T. E.
Published: May 2016

Both cis‐ and trans‐isomers of the perhydrothienooxazolethione dioxides (I) rearrange upon basic treatment, forming the cis‐perhydrothienothiazolone dioxides (II).
ChemInform Abstract: Radical Rearrangements of Bicyclo(2.2.0)hexane: Homolytic Substitution of a Cyclobutane Ring.
Authors: WALTON J. C.
Published: May 2016

Bicyclo(2.2.0)hexane (I) is brominated at the bridgehead carbon atoms under photolytic conditions, producing predominantly the 1,4‐dibromocyclohexanes (II) and (III).
ChemInform Abstract: Dodecacarbonyltriruthenium Catalyzed One‐to‐One Addition of N‐Substituted Formamides to Olefins.
Authors: TSUJI Y. , YOSHII S. , OHSUMI T. , KONDO T. , WATANABE Y.
Published: May 2016

Coupling of the formamides (I) with alkenes is achieved in the presence of a ruthenium carbonyl catalyst and carbon monoxide.
ChemInform Abstract: Preparation of N,N,N′‐Tris(trimethylsilyl)amidines. A Convenient Route to Unsubstituted Amidines.
Authors: BOERE R. T. , OAKLEY R. T. , REED R. W.
Published: May 2016

Reaction of lithium bis(trimethylsilyl)amide (II) with the benzonitriles (I) yields the lithiated benzamidine derivatives (III).
ChemInform Abstract: A Convenient Synthesis and Spectral Properties of Some New Iminium and 2‐Azaallenium Salts.
Authors: TASHTOUSH H. , AL‐TALIB M.
Published: May 2016

The iminium salts (II) and the 2‐azaallenium salts (IV) are prepared as shown.
ChemInform Abstract: Original Syntheses of Arylcycloalkanes.
Authors: KRIEF A. , BARBEAUX P.
Published: May 2016

The unsaturated methyl selenide (I) is cyclized in the presence of butyllithium to give a cyclopentylmethyllithium compound which reacts with methanol or benzaldehyde (V) to give predominantly the cyclopentanes (II).
ChemInform Abstract: Synthesis of 6,7,12‐Trimethylbenz(a)anthracene, 6,7‐Dimethyl‐, and 6,12‐Dimethylbenz(a)anthracene.
Authors: DAUB G. H. , DECK L. M. , LEON A. A.
Published: May 2016

The title compounds (VI) are prepared from the tetrahydronaphthylmethylbenzoic acids (I).
ChemInform Abstract: Hexahydropyrroloindoles. Attempts to Synthesize 2‐Indolyl Thioethers.
Authors: DROSTE H. , WIELAND T.
Published: May 2016

The tryptamine derivatives (IVa)‐(IVd) are synthesized as shown in the scheme.
ChemInform Abstract: A Convenient and One‐Pot Synthesis of 9‐Substituted Carbazoles from Primary Amine Hydrochlorides and 2,5‐Dimethoxytetrahydrofuran.
Authors: KASHIMA C. , HIBI S. , MARUYAMA T. , HARADA K. , OMOTE Y.
Published: May 2016

2,5‐Dimethoxytetrahydrofuran (I) reacts with the hydrochlorides (IIa), (IIb), and (IId), derived from primary amines, to form the carbazoles (III) via the pyrroles (IV).
ChemInform Abstract: Synthesis of Pyrrolo(2,1‐a)isoquinolines.
Authors: SHKLYAEV V. S. , ALEKSANDROV B. B. , MIKHAILOVSKII A. G. , VAKHRIN M. I.
Published: May 2016

The Ritter reaction products (I) are treated with oxalyl chloride (II) to give the title compounds (III).
ChemInform Abstract: Intramolecular Nitrone‐Quinone Cycloaddition. Formation of Isomeric Isoxazolidines by Kinetic and Thermodynamic Control.
Authors: SCHULTZ A. G. , MCMAHON W. G. , KULLNIG R. K.
Published: May 2016

The 2‐(2'‐formylbenzyl)‐p‐benzoquinones (I) react with N‐methylhydroxylamine (II) to give the nitrones (III).
ChemInform Abstract: Synthesis of N‐(Chloromethyl)‐2,6‐diethylcarbaniloyl Chloride and Derivatives.
Authors: D'AMICO J. J. , BOLLINGER F. G. , TUNG C. C. , DAHL W. E.
Published: May 2016

The imine (I) and phosgene (II) produce the N‐aryl‐N‐(chloromethyl)chloroformamide (III) which is coupled with the mercaptides (IV) to give the bissubstituted products (V).
ChemInform Abstract: Methylation of 3‐Methyl‐ and 3‐Phenyl‐4‐arylhydrazonoisoxazol‐5‐ones with Diazomethane.
Authors: SINGH S. K. , SUMMERS L. A.
Published: May 2016

The arylhydrazonoisoxazolones (I) react with diazomethane (II) to give the isomeric methylation products (III) and (IV).
ChemInform Abstract: Synthesis and Nitration with Nitric Acid of 1‐Alkenyl‐3,5‐dichloro‐ 1,2,3‐triazoles.
Authors: STOTSKII A. A. , LEBEDEVA N. P. , FOMINA V. V.
Published: May 2016

The dichlorotriazole (I) reacts with the alkenyl chlorides (II) or (IV) to give the title compounds (III).
ChemInform Abstract: C‐Acylation of p‐Acetotoluidide in Presence of Polyphosphoric Acid.
Authors: DESAI G. , DESAI K. K. , DESAI C. M.
Published: May 2016

N‐Acetyl p‐toluidine (I) reacts with acetic anhydride (II) in the presence of polyphosphoric acid to produce the isomeric acetaminoacetophenones (III) and (IV).
ChemInform Abstract: Synthesis of Some New Fluorine Containing 1H‐Pyrazolo(3,4‐b)pyridines.
Authors: JOSHI K. C. , PATHAK V. N. , SAREEN V. , GARG U.
Published: May 2016

The pyrazolopyridines (III) are obtained by coupling the aminopyrazoles (I) with the diarylpropenones (II).
ChemInform Abstract: Synthesis of Heterocycles Derived from Tetrahydroxanthone, Tetrahydroacridone, Tetrahydroacridine, or Octahydroacridine from (+)‐Camphor.
Authors: SOTIROPOULOS J. , EL BATOUTI N. , LAMAZOUERE A. M.
Published: May 2016

Camphor (I) is coupled with the carbonyl compounds (II) or (VI) in the presence of sodium amide, yielding the benzylidene derivatives (III) or (VII).
ChemInform Abstract: Quaternary Salts and Polymethine Dyes from 2‐(Methylpyridyl)‐X‐azolo‐(4,5‐b)pyridine.
Authors: SAVARINO P. , VISCARDI G. , BARNI E. , DI MODICA G.
Published: May 2016

Cyclocondensation of the pyridine derivatives (I) and (II) yields the 2‐(pyridyl)azolopyridines (III) which are quaternized to give the salts (V), (VII), or (XI).
ChemInform Abstract: Diazapolycyclic Compounds. Part 27. On the Selective Hydrogenation of Benzo(g)phthalazine‐1,4‐dione and 5‐Methoxybenzo(g)phthalazine‐1,4‐dione Adducts.
Authors: CAMPAYO L. , GOMEZ CONTRERAS F. , NAVARRO P.
Published: May 2016

The benzophthalazinediones (I), obtained from diazadiones and 1,3‐dienes, are hydrogenated to give the dihydro derivatives (II).
ChemInform Abstract: Synthesis and Antifungal Activity of a Series of Novel 1,2‐Disubstituted Propenones.
Authors: OGATA M. , MATSUMOTO H. , KIDA S. , SHIMIZU S. , TAWARA K. , KAWAMURA Y.
Published: May 2016

The 1,2‐disubstituted propenones (VIII) and (XIII) are prepared by the general synthetic routes outlined in the reaction scheme.
ChemInform Abstract: Syntheses and Biological Properties of 8‐Carbamoylimidazo(1,2‐c)pyrimidines and Their Heterocyclic Analogues.
Authors: DLUGOSZ A.
Published: May 2016

The 4‐mercaptopyrimidines (I) react with the amides (II) to give the 4‐aminopyrimidines (III).
ChemInform Abstract: Polycyclic N‐Hetero Compounds. Part 22. Reaction of Pyridine N‐Oxides and Pyrazine Di‐N‐oxides with Formamide.
Authors: HIROTA T. , NAMBA T. , SASAKI K.
Published: May 2016

The pyridine N‐oxides (I), quinoxaline 1,4‐dioxide (VI), and pyrazine 1,4‐dioxide (VIII) are heated in the presence of formamide, yielding various deoxygenated substitution products shown in the reaction scheme.
ChemInform Abstract: A Convenient Synthesis of Novel Pyridazino(3,4‐b)quinoxalines.
Authors: KURASAWA Y. , ARAI H. , ARAI K. , SATOH A. , NINOMIYA S. , OKAMOTO Y. , TAKADA A.
Published: May 2016

Cyclization of the hydrazonohydrazides (I) in the presence of hydrazine gives the tautomers (II) and (III).
ChemInform Abstract: Cyclization Reactions of Hydrazones. Part 19. Synthesis of N‐(4‐(3,6Dioxo‐2,3,4,6‐tetrahydro‐1,2,4‐benzotriazine‐2‐yl)benzoyl)‐L‐glutamic Acid.
Authors: SLOUKA J.
Published: May 2016

4‐Aminobenzoyl‐L‐glutamic acid (I) is diazotized and then coupled with the phenol (II) to form the azo compound (III) which is cyclized under basic conditions, yielding the title compound (IV).
ChemInform Abstract: Trichomonacidal Drugs. Part 6. 2,4‐Dichloro Derivatives of the Piperidino‐ and Piperazinyl‐1,3,5‐triazines.
Authors: KREUTZBERGER A. , KOCHANOWSKI R.
Published: May 2016

Cyanuric chloride (I) reacts with the cyclic amines (II) to give the triazines (III).
ChemInform Abstract: Studies on Diazepines. Part 26. Syntheses of 6H‐1,4‐Diazepines and 1‐Acyl‐1H‐1,4‐diazepines from 4‐Pyridyl Azides.
Authors: SAWANISHI H. , TAJIMA K. , TSUCHIYA T.
Published: May 2016

The azidopyridines (III), prepared as shown in the reaction scheme, are subjected to photolysis, forming the diazepines (V).
ChemInform Abstract: A One‐Pot Three Carbon Decarboxylative Ring Expansion of Cyclic Secondary Amino Acids. X‐Ray Crystal Structure of a Substituted 1‐Azacycloocta‐2,4‐diene.
Authors: ARDILL H. , GRIGG R. , SRIDHARAN V. , MALONE J.
Published: May 2016

The heterocyclic amino acids (I), (VI), and (VIII) react with paraformaldehyde (III) and methyl propiolate (IIa) or dimethyl acetylenedicarboxylate (IIb) to give the ring expansion products (IV), (VII), and (IX).
ChemInform Abstract: Reaction of Phosphorus Ylides with Acylating Agents in a Two‐Phase System.
Authors: LISTVAN V. N. , STASYUK A. P. , KURGAN L. N.
Published: May 2016

The ylides (II), generated from the phosphonium salts (I) in a two‐ phase system, react in situ with the acyl chlorides (III) to give the acylated phosphoranes (IV).
ChemInform Abstract: Pentacoordinate Zinc Complexes of Imidazole Nitrogen Donors as Structural Models for the Active Site in Enzymes: Preparation and Crystal Structures of (μ‐2,2‐Biimidazole)tetrakis(2,2′‐biimidazole)dizinc(II) Tetraperchlorate Trihydrate and Bis(2,2′‐biimidazole)(formato)zinc(II) Perchlorate.
Authors: KIRCHNER C. , KREBS B.
Published: May 2016

The reaction of Zn perchlorate with the biimidazole ligand in water gives (I), crystallizing in the space group P212121 with Z=4.
ChemInform Abstract: Effect of Ring Size on Properties of Technetium Amine Oxime Complexes. X‐Ray Structures of TcO2Pent(AO)2, Which Contains an Unusual Eight‐Membered Chelate Ring, and of TcOEn(AO)2.
Authors: JURISSON S. , ASTON K. , FAIR C. K. , SCHLEMPER E. O. , SHARP P. R. , TROUTNER D. E.
Published: May 2016

The Tc(V) complexes (I)‐(III) are prepared by the reduction of ammonium pertechnetate with stannous ion in the presence of the corresponding ligand in aqueous medium at pH 8‐9. The length of the hydrocarbon backbone of the amine oxime ligand is varied to effect chemical changes in the complexes.
ChemInform Abstract: Preparation and Characterization of the Dimetallo Ketone Complexes Ir2(μ‐S‐t‐Bu)2(μ‐CO)L2(CO)2I2: Crystal and Molecular Structure of the Complex Where L: PMe3.
Authors: CLAVER C. , FIS J. , KALCK P. , JAUD J.
Published: May 2016

Fast addition of iodine immediately after the addition of the phosphorus ligands to the complex (I) induces, in the case of the very basic ligands (II), the formation of the title complexes (IV).
ChemInform Abstract: Study of the Rotational Isomerism and Synthesis of Glucosides Derived from Pyrazino(2,3‐c) (1,2,6)thiadiazine 2,2‐Dioxides.
Authors: GOYA P. , MARTINEZ A. , JIMENO M. L. , PFLEIDERER W.
Published: May 2016

Glucosidation of the pyrazinodiazine dioxides (I) with the component (IV) is best effected via the "silylation method"; the products (III) are subsequently transformed to the respective free nucleosides which exist as rotationally restricted "syn‐anti" isomers (IV), (V).
ChemInform Abstract: pKa and pH Dependence of the Formation of Nitroxide Radicals from Some Drug Substances with an Aliphatic Secondary Amino Group by Oxidation with Hydrogen Peroxide. An ESR Study.
Authors: LAGERCRANTZ C.
Published: May 2016

It is found that the yields of radicals formed from ephedrine (I), timolol (II), metoprolol (III), and terodiline (IV) are dependent on the pKa value of the parent substance, and consequently on the pH of the reaction mixture since radicals are formed from the free bases only.
ChemInform Abstract: Crystal and Molecular Structure of Potassium Hexaiodotechnetate(IV)
Authors: KRYUCHKOV S. V. , GRIGOR'EV M. S. , KUZINA A. F. , SPITSYN V. I.
Published: May 2016

K2TcI6, are investigated using a single crystal.
ChemInform Abstract: Product Determination of Gaseous Radical Reactions Using Matrix Isolation‐FTIR Detection.
Authors: KUO Y.‐P. , JU S.‐S. , LEE Y.‐P.
Published: May 2016

Combination of the discharge flow technique and the matrix isolation‐FTIR technique is demonstrated to be an excellent ability to study the products of radical reactions under well‐characterized conditions, which are free from secondary interfering reactions.
ChemInform Abstract: Cesium Hydroxogermanate.
Authors: IVANOV‐EMIN B. N. , ZAITSEV B. E. , KOSTRIKIN A. V. , LIN'KO I. V. , EZHOV A. I. , NALIVAIKO I. K.
Published: May 2016

The novel title compound, Cs(Ge(OH)6), is prepared in aqueous solution from CsOH and GeO2.
ChemInform Abstract: Exciton Effects in Chiral Planar 1,3‐Dienes and α,β‐Unsaturated Carbonyl Compounds. Configurational Application.
Authors: GAWRONSKI J. K. , REDDY S. M. , WALBORSKY H. M.
Published: May 2016

The exciton couplings between a benzoate chromophore and planar 1,3‐diene as well as α,β‐unsaturated carbonyl chromophore for determination of the absolute configuration of the axially dissymmetric benzoates (I)‐(VI) are investigated.