bluuebunny/crossref_metadata_2025 huggingface dataset:
Undergoing multiple red blood cell transfusions is associated with poorer outcomes in very low birth weight infants
Authors: Fang Xiaohong , Huang Dali , Zeng Huibin , Xu Liping
Published: January 2024

Objective: This study was designed to assess red blood cell (RBC)
transfusion frequency in very-low-birth-weight (VLBW)infants and to
understand the relationships between the number of transfusions and the
composite risk of bronchopulmonary dysplasia (BPD), retinopathy of
prematurity (ROP), and mortality. Method: VLBW infants admitted from May
2017 – July 2019 were retrospectively analyzed. Relationships between
gestational age (GA), birth weight (BW), numbers of transfusions, and
comorbidities were evaluated through Pearson correlation analyses. The
relationship between factors of interest (Model 1: GA, BW,
comorbidities; Model 2: number of transfusions) and composite risk was
assessed via a logistic regression approach. Results: Overall,408 VLBW
infants were enrolled, of whom 74% underwent at least one RBC
transfusion. Infants with a GA<30 weeks, a BW<1,250
g, and comorbidities were more likely to require RBC transfusion. Number
of transfusions was related to the risk of analyzed composite outcomes,
with risk correlating with undergoing >3 transfusions (OR:
3.275, 95% CI: 1.707–6.275). Conclusion:We found that undergoing
> 3 RBC transfusions was related to an increased risk of
BPD, ROP, or death in VLBW infants.
MicroRNA319-targeted RaTCP1 Regulates Heterophyllic Alteration in North American Lake Cress
Authors: Hu Shiqi , Li Gaojie , Yang Jingjing , Sakamoto Tomoaki , Ikematsu Shuka , Zhao Xuyao , Kimura Seisuke , Schultz Elizabeth , Hou Hongwei
Published: January 2024

Heterophylly, the plasticity of leaf form in response to environmental
conditions, occurs in aquatic and amphibious plants where it modulates
water availability, gas exchange and photosynthesis to maximize plant
productivity. Rorippa aquatica produces simple leaves in
terrestrial conditions but dissected leaves under submerged conditions.
Regulation of CIN-TCP transcription factors by miR319 controls leaf
complexity in a number of species and we provide evidence that this
regulatory module acts in R. aquatica heterophylly. RaTCP1
was identified as the most likely target of Raq-miR319b. Under
conditions that induced increased leaf complexity, RaTCP1
expression was reduced whereas Raq-miR319b expression was
increased. Overexpression of Raq-miR319 in Arabidopsis
thaliana reduced TCP gene expression and increased leaf
serration. Similarly, a repressive form of RaTCP1 expressed in
either A. thaliana or R. aquatica resulted in more complex
leaves. Our results indicate that the environmental induction of
dissected leaves in R. aquatica occurs through down-regulation of
RaTCP by Raq-miR319.
CA 19-9 and CA 72-4 Levels in Patients with Subclinical Hypothyroidism due to Hashimoto's Thyroiditis and the Effect of L-Thyroxine Treatment
Authors: Demirci Hüseyin , Ünal Huriye , Coşar Ramazan
Published: January 2024

AIMS: The purpose of this study is to investigate the changes of tumor
markers with increasing utilization area in recent years in Hashimoto’s
thyroiditis patients with subclinical hypothyroidism. METHODS: The
serums of 30 newly diagnosed Hashimoto’s thyroiditis patients with
subclinical hypothyroidism were collected before and 6 weeks after the
treatment with L-T4. Thirty healthy volunteers were taken as the control
group. TSH, thyroid hormones, anti-TPO, anti-T, CA 19-9 and CA 72-4 were
studied in all patients. RESULTS: There was no significant differences
in the levels of CA 19-9 and CA 72-4 in Hashimoto’s thyroiditis patients
with subclinical hypothyroidism compared to the control group (p = 0.35
and p = 0.45, respectively). Significant difference was found in CA 19-9
value after the treatment with L-T4 (p = 0.04). Also a significant
correlation between TSH and anti-TPO with CA 19-9 levels has been
determined (p = 0.07, r = 0.484 and p = 0.001, r = 0.799, respectively).
CONCLUSION: CA 72-4 studied for the first time in Hashimoto’s
thyroiditis, has been determined as not different from healthy controls
and the levels are not changed after the treatment with L-T4. To
understand the reasons of why a significant increase has been shown in
CA 19-9 after treatment, we believe that there is a need for long term
new studies with more patients. Key Words: Subclinical Hypothyroidism,
Hashimoto’s Thyroiditis, CA 19-9, CA 72-4
Experimental investigation of electrohydrodynamic (EHD) effect on bubble dispersion characteristics in ethanol
Authors: Wei Zhang , Wang Junfeng , Li Bin , Zhan Shuiqing , Huang Yuejie , Xu Haojie
Published: January 2024

This study focuses on the bubble dispersion characteristics in
leaky-dielectric liquid medium under non-uniform electric field. It is
shown that bubbles dispersion under the electric field can detach with a
considerably smaller diameter and a wider diffusion area than that
without electric field. The study also demonstrates the critical role
played by the flow rate and voltage in the bubble interactions. A
considerable control over the bubble dispersion regime and generation
size can be achieved by a careful consideration of the parameters, which
are the extremely difficult ones to realize in practice. Accordingly, an
empirical correlation of bubble detachment diameter (ζ) as a function of
modified Weber number (WeE) and Reynold number (Re) is established based
on the present experimental data. The relationship between bubble
dispersion angle (θ) and regime variation with WeE and Re is explicated.
The impact of electric field strength and interaction on bubble
deformation is confirmed.
Nursing of a Patient with Fever and Psychotic Disorder in the Initial Stage of COVID-19 Outbreak: A Case Report
Authors: Tang Hongxia , Zhong Mengting , Wang Qin , Zhang Mingjiao , Zeng Jing , Li Zhe , Xiong Zhenzhen
Published: January 2024

In the initial stage of the COVID-19 outbreak, this disease was not well
known by the general public, including professional medical personnel.
In the face of such a severe infectious public health event, they
endured huge physical and psychological pressure under the lack of
effective epidemic prevention materials and the unclear diagnostic
criteria.Due to the particularity, complexity and variability of the
patient of psychiatric staff, they bore severer physical and mental
pressure than other ordinary medical staff. thus we report the nursing
experience in a patient with fever and psychotic disorder who did not
cooperate with treatment during the initial stage of the COVID-19
outbreak. This case can provide information that would enable better
nursing in the future for patients with psychotic disorder during the
period of COVID-19 pandemic and other infectious diseases.
Simple or hybrid? The performance of next generation ecological models to study the response of Southern Ocean species to changing environmental conditions
Authors: GUILLAUMOT Charlene , Belmaker Jonathan , Buba Yehezkel , Fourcy Damien , Dubois Philippe , Danis Bruno , Saucède Thomas
Published: January 2024

Ecological modelling is widely used in the various fields of ecology but
models usually require large datasets, a serious limitation to the
approach for application to organisms of remote and little studied
regions such as polar seas. Correlative and mechanistic modelling
approaches are usually used independently in distinct studies. Using
both approaches in integrative, hybrid models however can help better
estimate the species realised niche, as mechanistic and correlative
models complement each other very well, giving more insights into
species potential response to fast changing environmental conditions. In
this study, we implemented for the first time an hybrid, correlative and
mechanistic model to predict the response of a marine invertebrate
endemic to the Southern Ocean, the sea urchin Abatus cordatus (Verrill,
1876). We compared the respective performance of simple and hybrid
models by analyzing the effect of seasonality on species distribution, a
key feature of ecosystem functioning at high latitudes. Higher
performances were obtained for the ‘integrated Bayesian’ approach
compared to simple mechanistic and correlative models. The hybrid model
more precisely predicts the effect of seasonality on habitat
suitability. Such results are promising and show that hybrid approaches
can be applied to case studies for which limited datasets are available.
Management strategies of fibrous dysplasia involving the paranasal sinus and the adjacent skull base
Authors: Shi Li , Xiong Peng , Zhen Hongtao
Published: January 2024

Objective: The current management of fibrous dysplasia (FD) involving
the paranasal sinuses and the adjacent skull base is controversial. This
study is to present our experience in the management strategy of FD
involving the paranasal sinuses and the adjacent skull base.
Design/setting: 23 patients from 2006 to 2019 with monostotic fibrous
dysplasia (MFD), polyostotic fibrous dysplasia (PFD), or McCune-Albright
Syndrome (MAS) involving the paranasal sinuses and the adjacent skull
base were retrospectively reviewed. This study series was divided into 3
groups based on the management strategies: the observation group, the
surgery group, and the optic nerve decompression group. Main
outcome/results: The observation group included 9 asymptomatic MFD
patients with a stable condition during the follow-up period of 15 to
164 months. The surgery group included 10 symptomatic MFD patients
having personalized endoscopic endonasal surgery. The patients’ symptoms
were relieved after surgery. The optic nerve decompression group
included 4 patients with visual loss, who underwent endonasal endoscopic
optic nerve decompression with the aid of image-guided navigation. Their
vision improved after surgery. Conclusion: The clinical observation and
periodic computed tomography (CT) scan is adopted for asymptomatic
patients. Surgery is indicated in symptomatic patients. Optic nerve
decompression is recommended as soon as possible if the patient has
visual loss, whereas prophylactic decompression is not recommended if
the optic nerve is encroached upon by FD without visual loss. Navigation
plays an important role in endoscopic surgery involving the paranasal
sinuses and the adjacent skull base, especially in FD resection and
optic nerve decompression.
Using Fuzzy-Rough Subset Evaluation for Feature Selection and Naive Bayes to Classify the Parkinson's Disease
Authors: mohammadi naiyer , Çelik Ercan
Published: January 2024

Feature selection is one of the issues in machine learning as well as
statistical pattern recognition. This is important in many fields (such
as classification) because there are many features in these areas, many
of which are either unused or have little information load. Not
eliminating these features does not make a problem in terms of
information, but it does increase the computational burden for the
intended application. Besides, it causes to store of so much useless
information along with useful data. A problem for machine learning
research occurs when there are many possible features with few
attributes of training data. One way is to first specify the best
attributes for prediction and then to classify features based on a
measure of their dependence. In this study, the Fuzzy- Rough subset
evaluation has been used to take features in core of similar features.
Fuzzy-rough set-based feature selection (FS) has been demonstrated to be
extremely advantageous at reducing dataset size but has various problems
that yield it unproductive for big datasets. Fuzzy- Rough subset
evaluation algorithm indicates that the techniques greatly decrease
dimensionality while keeping classification accuracy. This paper
considers classifying attributes by using fuzzy set similarity measures
as well as the dependency degree as a relatedness measure. Here we use
Artificial Neural Network, Naïve Bayes as classifiers, and the
performance of these techniques are compared by accuracy, precision,
recall, and F-measure metrics.
Breech assisted vaginal delivery and the role of simulation-based training according to the PROMPT in a low-income setting: a retrospective cohort study
Authors: Yared George , Hatoum Inaam , Krounbi Amina , Elhajjar Charlotte , Khazaal Janoub
Published: January 2024

Objective: to assess the effect of a simulation -based training program
(PROMPT) on the mode of delivery of breech presentation and to evaluate
the neonatal outcomes. Design: a retrospective cohort study Setting:
Rafic Hariri University Hospital (RHUH), a tertiary center in Beirut,
Lebanon Population: A total of 92 pregnant women delivering a singleton
with a breech presentation between June 2018 and December 2019 Methods:
We used data from the local perinatal registry at the RHUH. Clinical
outcomes were analyzed according to whether the obstetrician attended
the “Train The Trainer” course of the PROMPT or not. Main outcome
measures: Clinical measures include: the prevalence of cesarean
deliveries in the groups R6 and R7 according to the Robson’s
classification and neonatal outcomes (Apgar score at 1 and 5 minutes and
admission to the neonatal intensive care unit (NICU) Results: The
prevalence to deliver a breech presentation by assisted vaginal delivery
is increased in group R6 of Robson’s classification and not in group R7
after the simulation and the retention of skills is time-related. No
adverse neonatal outcomes were noted in both groups. Conclusion: The
simulation-based course improved the management of assisted vaginal
delivery in breech presentation mainly in group R6 of Robson
classification, without increasing neonatal complications and the
retention of skills decreases over time. Keywords: simulation, breech
delivery, Robson classification, PROMPT
Maximum likelihood degree of surjective rational maps
Authors: Karzhemanov Ilya
Published: January 2024

With any \emph{surjective rational map} $f:
\p^n \dashrightarrow
\p^n$ of the projective space we associate a
numerical invariant (\emph{ML degree}) and compute it
in terms of a naturally defined vector bundle $E_f \map
\p^n$.
Characterization of the potential role of NTPCR in epithelial ovarian cancer by integrating transcriptomic and metabolomic analysis
Authors: Shang Hongkai , Zhang Huizhi , Zhao Hongjiang , Tong Jinyi
Published: January 2024

Epithelial ovarian carcinoma (EOC) is a malignant tumor with high
motility in women. Our previous study found that dysregulated NTPCR was
associated with the prognosis of ovarian cancer patients, and thus this
present study attempted to explore the potential roles of
nucleoside-triphosphatase cancer-related (NTPCR) in disease progression.
Estimating the Burden of Adult Hospitalized RSV Infection Using Local and State Data - Methodology
Authors: Balasubramani GK , Nowalk Mary Patricia , Eng Heather , Zimmerman Richard
Published: January 2024

Background: Respiratory syncytial virus (RSV) is becoming increasingly
recognized as a serious threat to vulnerable population subgroups. The
Epidemiology, Burden, and Cost (EBC) of RSV Infection Study is a
retrospective cohort study of adults hospitalized for acute respiratory
infection (ARI) designed to estimate the population burden of RSV
especially for specific groups such as the elderly, pregnant women and
solid organ transplant patients. This paper describes the design and
statistical analysis plan for the study. Methods: The study population
will consist of residents of Allegheny County, Pennsylvania ≥18 years of
age who were hospitalized in Pennsylvania during the period September 1,
2015 to August 31, 2018. Several data sources will be used including
U.S. Census, Pennsylvania Health Care Cost Containment Council (PHC4),
and the electronic medical record for the health system to which the
hospitals belong. The algorithm involves: 1) ARI-associated
hospitalizations in PHC4 data; 2) adjustment for ARI hospitalizations
among county residents but admitted to hospitals outside the county, and
3) RSV detections from respiratory viral panels (RVPs). Key sensitivity
analyses will adjust for undertesting for viruses in the fall and spring
quarters. The results will be population-based estimates, stratified by
age and risk groups. Conclusion: Adjusting hospitalization data using a
multiplier method is a relatively simple means to estimate the impact of
RSV in a given area. This algorithm can be applied to other health
systems and localities to estimate burden of RSV in adults, as well as
burden of other respiratory pathogens.
The Characteristics of New Dendritic Cell Subsets Expressing CD205 and/or CD103 in Human Peripheral Blood Mononuclear Cells
Authors: Xu Wenlong , Gu Yanli , Lu Yong , Rong Zhien , Chang Xu , Qin Li , Chen Xiaoping , ZHOU FANG
Published: January 2024

There are three types of dendritic cells (DCs) including CD1c+
conventional DCs (cDCs), CD141+cDCs and CD303+plasmacytoid DCs (pDCs) in
human peripheral blood, however, more details of DC subsets are still
obscure. Here we systemically investigated the subpopulations of human
blood-derived DCs. Our data showed that there are three subsets of
CD1c+cDCs and three subpopulations of CD141+cDCs expressing CD205 and/or
CD103 in human peripheral blood. CD303+pDCs can be divided by two
groups: CD303high(hi) and CD303lowpDCs expressing CD205 and/or CD103.
There are six new subpopulations expressing CD205 and/or CD103 in
CD303+pDCs. The protein expression of co-stimulatory molecules and the
production of pro-/anti-inflammatory cytokines by these cDC and pDC
subsets are different from those of each other. Our results imply that
CD1c+CD205-DC, CD141+CD205- cDC and CD303+CD205-pDC subpopulations may
be immune tolerogenic and immature DCs, but CD1c+CD205+cDC,
CD141+CD205+cDC and CD303+CD205+pDC subsets are probably inflammatory
and mature DCs due to their different levels of co-stimulatory molecule
expression and pro-/anti-inflammatory cytokine production. The
subpopulations of cDCs and pDCs expressing CD205 and/or CD103 in human
peripheral blood may perform diverse immune functions according to their
different biological features, therefore, these new subsets of cDCs and
pDCs may be potential targets for immunotherapy to treat autoimmune
diseases and tumors in the clinical trials in the future.
A Three Fractional Order Jerk EquationWith Anti Periodic Conditions
Authors: Dahmani Zoubir , BELHAMITI Meriem Mansouria , Sarikaya Mehmet Zeki
Published: January 2024

We study a new Jerk equation involving three fractional derivatives and
anti periodic conditions. By Banach contraction principle, we present an
existence and uniqueness result for the considered problem. Then, by
applications of Krasnoselskii fixed point theorem, another result for
the existence of at least one solution is established. Also, An
illustrative example is discussed. At the end, an approximation for
Caputo derivaitive is proposed and some chaotic behaviours are discussed
by means of the Runge Kutta 4th order method.
Kinetic Modelling of Catalyst Synthesis Process of Biodiesel Preparation Experiments- A Theoretical Communication
Authors: BHARADWAJ A V S L SAI , SUBRAMANIAPILLAI NIJU , MOHAMMED MEERA SHERIFFA BEGUM KHADHAR , NARAYANAN ANANTHARAMAN
Published: January 2024

An effective kinetic modelling for catalyst preparation process of
biodiesel preparation experiments has been proposed in this study.
Development of kinetic modelling for catalyst synthesis process is
verified by two sample examples like calcination of raw eggshells and
calcination of calcium aluminate (Impregnation of alumina (Al2O3) with
calcined eggshells). Development of kinetic modelling for catalyst
synthesis process of biodiesel production experiments will be more
useful to determine at what rate the catalyst decomposition takes place
during its preparation. Identification of reaction rate constant in
prior will be more helpful in determining the selectivity of the
catalyst chosen. It is observed from this study that for any catalyst
synthesis process of biodiesel preparation experiments a complete
kinetic modelling can be derived easily as proposed.
ASTHMA AND COVID 19: EMPHASIS ON ADEQUATE ASTHMA CONTROL
Authors: NASSORO DAVID
Published: January 2024

Asthmatics are at an increased risk of developing exacerbations after
infection by respiratory viruses such as Influenza virus (IV),
Parainfluenza virus, and Human and severe acute respiratory syndrome
Coronaviruses. Asthma itself, mainly when poorly controlled, is an
independent risk factor for pneumonia. A subset of Asthmatics can have
significant defects in their innate, humoral, and cell-mediated immunity
arms, and it may explain the increased susceptibility to infections.
With the current COVID 19 pandemic affecting millions of people
worldwide and with mortality several times that of seasonal Flu, it was
necessary to revisit this subject. The pathogenesis of SARS-CoV-2, the
virus that causes COVID 19, can potentiate the development of acute
asthmatic exacerbation with the potential to worsen the state of chronic
airway inflammation. The relationship is evident from several studies
that show asthmatics experiencing a more adverse clinical course of
SARS-CoV-2 infection than non-asthmatics. Recent studies show that
Dexamethasone significantly decreased mortality among admitted COVID 19
patients. However, the benefit of inhaled corticosteroids, especially in
asthmatics, is still inconclusive. Hence, while we are waiting for more
studies that further narrates the association between COVID 19 and
Asthma, individualizing asthmatics management among clinicians is
crucial to achieving adequate disease control.
Epidemiological Trends of Trans-Boundary Tick-Borne Encephalitis in Europe, 2000-2019
Authors: Wondim Mulugeta , Czupryna Piotr , Pancewicz Sławomir , Kruszewska Ewelina , Moniuszko-Malinowska Anna
Published: January 2024

Tick-borne encephalitis is a neuroinfection caused by the Tick-Borne
Encephalitis Virus. It is transmitted primarily by tick bite and rarely
because of consuming raw milk. It has been discovered in the 1930s. The
disease covers the Euro-Asia region which also known as the tick-borne
encephalitis belt. It is prevalent in most parts of Europe. The top
affected parts of Europe include Southern Germany, Switzerland, the
Czech Republic, Austria, Slovakia, Hungary, the Baltic countries,
Slovenia, Poland, parts of Scandinavia, and European Russia. Since 2000,
in Europe the total number of confirmed cases reported to the European
CDC was 51,519. There were signs of decreasing number of cases in 2014
and 2015 however after 2015 a steadily increasing number of cases with
involvement of countries which had no history of tick-borne
encephalitis. Within Europe, from 1950 to 2006 ticks were prevalent
between 600 to 2000 meters above sea level of altitude. The determinant
factors for the spread of tick-borne encephalitis are host population
size, weather, movement of hosts, altitude, and local regulations on
socio-economic dynamics of the local and travelling people around the
foci areas. The mean incidence rate of tick-borne encephalitis since
2000 to 2019 in Europe was 3.27 while the age adjusted mean incidence
rate was 2.19 per 100,000 population size. The recent increase is mainly
associated with human activity as a dominant factor since there are new
foci areas with no significant climate change. This review used several
articles and data sources from the European Center for Diseases
Prevention and Control and Polish National Public Health Institute to
examine the trend of TBE across Europe and in Poland in particular.
A PERCUTANEOUS TREATMENT TO INFERIOR VENA CAVA PERFORATION BY INTRACARDIAC ECHOCARDIOGRAPHY CATHETER AFTER AN UNSUCCESSFUL CONSERVATIVE APPROACH
Authors: Vassallo Fabricio , França Rodrigo , Lovatto Carlos Alexandre , Carvalho Bruno , Magalhaes Alessandra , Serpa Eduardo , Cunha Christiano
Published: January 2024

Catheter ablation is a well-established treatment for drug refractory
arrhythmia and intracardiac echocardiography is one of the tools used
for this purpose. Despite a high volume of procedures performed
worldwide the incidence of vascular complications still very low. We
describe a case report of a percutaneous treatment to an inferior vena
cava perforation by an intracardiac echocardiogram catheter after the
failure of a conservative approach.
AHU 377 is commercially hidden molecula?
Authors: Gasimov Zaur
Published: January 2024

ARNI-drug, which consists of two components: the blocker of angiotensin
receptors -valsartan and the neprilysin inhibitor-sacubitril. As a rule,
the drugs available in cardiological practice, both two-component and
fixed 3 or more component, consist of a combination of drugs that are
successfully used as monotherapy. Examples include calcium antagonists,
β-blockers, hydrochlorothiazide, indapamide, valsartan, perindopril,
etc. All these drugs have been used successfully for many years as
monotherapy, and nowadays, both as monotherapy and in combinations.But
sacubitril is only drug in cardiovascular practice which is not
recommended as monotherapy,only as combination – sacubitril/valsartan.
LCZ 696 were represented by drug makers as very difficult to create,
even at 696 attempt, < monolith molecule>. Cause
of ? The reason is not entirely clear and, as I understand it, is
explained by the necessity of compulsory fusion into a for the
simultaneous release of both components of both valsartan and
sacubitrile so that valsartan mitigates the negative effect of
sacubitril caused NEP-dependent degradation of angiotensin II.Weak
explanation,isn’t it? But No sacubitril monotherapy studies were
conducted. However, a sacubitril 200 mg monotherapy arm of 165 patients
was included in the HTN study CLCZ696A2201. A Multi-center, Randomized,
Double-blind, Placebo and Active Controlled, Parallel Group, Dose Range
Study to Evaluate the Efficacy and Safety of LCZ696 Comparatively to
Valsartan, and to Evaluate AHU377 to Placebo After 8 Week Treatment in
Patients With Essential Hypertension. In monotherapy arm, participants
received AHU377 200 mg and matching placebo to LCZ696 and Valsartan.
Efficacy of Denosumab in Bone Mineral Density Evolution in Patients with Prostate Cancer under Different Schemes of Androgen Deprivation Therapy: A Real-World Setting Study
Authors: Ruales Karla Arevalo , Cortés José Ivorra , García Elena Grau , Donoso Cesar David Vera , Martínez José Antonio Cañada , Ivorra José Andrés Román
Published: January 2024

Rationale, Aims and Objectives: Antiresorptive treatment in androgen
deprivation therapy (ADT) has proved effective in clinical trials,
however its real-world efficacy has not been reported. Furthermore,
different schemes of ADT are available and its effect on bone health is
still under study. The objectives of this research is are to evaluate
the basal and evolution of bone health of patients with prostate cancer
receiving different schemes of luteinizing hormone-releasing hormone
(LH-RH) agonists. Furthermore, to assess the effect of antiresorptive
treatment in a real-world setting. Material and Methods: A 24-month
longitudinal observational study with a standardized clinical practice
was conducted. Demographics, osteoporosis risk factors, LH-RH treatment
regimen, osteoporosis treatment were collected. Laboratory tests and BMD
were compiled. Antiresorptive treatment compliance was reviewed in a
post-hoc study. Results: 83 patients (mean age 71 ± 8 years) completed
basal evaluation. 57 patients completed 24-month follow-up. At the basal
evaluation, 80% of patients had inadequate vitamin D levels. Vitamin D
>30 ng/mL was correlated with higher T-scores. Continuous
LH-RH agonists scheme was associated with a decrease in BMD, especially
at the total hip. Adding antiresorptive treatment was correlated to
statistically significant better BMD evolution in patients under
continuous LH-RH agonist scheme. Patients with intermittent LH-RH
treatment and without antiresorptive treatment showed a better evolution
at femoral neck BMD. More than one-third of patients under LH-RH
intermittent scheme had problems with compliance of denosumab.
Conclusion: Bone health assessment in patients with LH-RH agonist
treatment is essential. Inadequate vitamin D levels were commonly
presented in our patients, suggesting that bone health evaluation in
these patients is still underperformed. Intermittent LH-RH scheme and
antiresorptive treatment correlated to a better evolution of BMD.
Denosumab patients’ non-compliance can become a problem in patients
under intermittent LH-RH scheme, which could lead to a decrease of its
efficacy.
The accuracy of heartbeat detection using photoplethysmography technology in cardiac patients
Authors: Blok Sebastiaan , Piek Martijn , Tulevski Igor , Somsen Aernout , Winter Michiel
Published: January 2024

Introduction Photoplethysmography (PPG) in wearable sensors potentially
plays an important role in accessible heart rhythm monitoring. We
investigated the accuracy of a state-of-the-art bracelet (Corsano 287)
for heartbeat detection in cardiac patients and evaluated the efficacy
of a signal qualifier in identifying medically useful signals. Methods
Patients from an outpatient cardiology clinic underwent a simultaneous
resting ECG and PPG recording, which we compared to determine accuracy
of the PPG sensor for detecting heartbeats within 100 and 50 ms of the
ECG-detected heart beats and correlation and Limits of Agreement for
heartrate (HR) and RR-intervals. We defined subgroups for skin type,
hair density, age, BMI and gender and applied a previously described
signal qualifier. Results In 180 patients 7,914 ECG-, and 7,880 (99%)
PPG-heartbeats were recorded. The PPG-accuracy within 100 ms was 94.6%
(95%CI 94.1-95.1) and 89.2% (95%CI 88.5-89.9) within 50 ms.
Correlation was high for HR (R = 0.991 (95%CI 0.988-0.993), n = 180)
and RR-intervals (R = 0.891 (95%CI 0.886-0.895), n = 7880). The 95%
Limits of Agreement (LoA) were -3.89 to 3.77 (mean bias 0.06) beats per
minute for HR and -173 to 171 (mean bias -1) for RR-intervals. Results
were comparable across all subgroups. The signal qualifier led to a
higher accuracy in a 100 ms range (98.2% (95%CI 97.9-98.5)) (n=143).
Conclusion We showed that the Corsano 287 Bracelet with PPG-technology
can determine HR and RR-intervals with high accuracy in cardiovascular
at-risk patient population among different subgroups, especially with a
signal quality indicator.
Extracorporeal Cardiopulmonary Resuscitation Treatment of Cardiac Arrest during Pregnancy: Case Report and Mini-review
Authors: Lin Fei , Cao Yong , Fan Ting , Xia Qingping , Deng Li , Xian Minghai , He Youkuan , Peng Huajian , He Haijie
Published: January 2024

This paper presents a pregnant woman successfully rescued in cardiac
arrest (CA) using extracorporeal cardiopulmonary resuscitation (ECPR)
for up to 5.5 hours. We reviewed the literature on the use of ECPR
during pregnancy. Published data suggest that extracorporeal membrane
oxygenation (ECMO) appears to be a viable treatment option for pregnant
women who have experienced critical situations, such as a maternal CA or
an amniotic fluid embolism.
An Astonishing Extrarenal Wilms Localisation; Spinal Cord
Authors: Tokuc Gulnur , Eker Nurşah , Tas Burcu Tufan , Uyar Süheyla Bozkurt , Sakar Mustafa , Aras Seda , Akar Kadriye Ebru
Published: January 2024

Wilms’ tumor is one of the most common childhood solid malignancies,
which accounts for almost 95% of renal malignancies in pediatrics, and
classically arises from primitive metanephric cells. Exceptionally it
may occur at places other than kidneys. The estimated rate of
nephroblastoma outside the kidneys is almost 0.5 to 1% of Wilms’ tumor
cases. Extrarenal Wilms’ tumor occurs mostly in childhood. In this
article, we report a 3-year-old girl who first presented with spinal
dysraphism and a mass in the lumbar spinal cord with a histopathological
diagnosis of nephrogenic rest, and after one year, a Wilms tumor arose
in this location. When extrarenal wilms tumor located in the spine is
unlikely to be suspected preoperatively because it is embryologically
less intuitive. Thus, we report this case of a congenital Wilms tumor
associated with spinal dysraphism to increase awareness and describe
this malignant tumor’s clinical outcome.
FETAL PULMONARY ARTERY DOPPLER PARAMETERS IN PREGNANCIES COMPLICATED WITH INTRAHEPATIC CHOLESTASIS OF PREGNANCY: A PROSPECTIVE CASE-CONTROL STUDY
Authors: yakıştıran betül , Tanacan Atakan , Altınboğa Orhan , elbayiyev sarkhan , canpolat emre , Yucel Aykan
Published: January 2024

ABSTRACT Objective: The primary aim of this study was to determine
whether PATET was altered in the fetuses whose mothers were complicated
by intrahepatic cholestasis of pregnancy (IHCP). The secondary aim was
to investigate the association between fetal pulmonary artery Doppler
parameters with neonatal outcomes in pregnancies complicated by IHCP.
Methods: This prospective case control study was conducted in a tertiary
perinatal-neonatal center. A total of 18 fetuses whose mothers were
complicated by IHCP were set as the study group and a total of 37
fetuses whose mothers were healthy were selected as the control group.
Fetal pulmonary artery Doppler parameters (acceleration time -AT;
ejection time -ET; AT/ET ratio) were assessed and neonatal outcomes were
evaluated. Results: Mean pulmonary artery AT, ET, PATET were
statistically significant different between the groups (p=0,001; p=0,024
and p=0,003, respectively). The mean PATET value in the IHCP group was
0,217 ± 0,029 while in the control group it was 0,180 ± 0,020 (p=0,003).
While PATET values were correlated with gestational age at birth,
respiratory distress and NICU admission were not correlated with PATET.
Conclusions: Higher values of PATET may be helpful to understand fetal
lung damage secondary to IHCP. Keywords: acceleration time; ejection
time; intrahepatic cholestasis; pulmonary artery
Lower and upper bounds for the explosion times of a system of semilinear SPDEs
Authors: S Sankar , Mohan Manil , S Karthikeyan
Published: January 2024

In this paper, we obtain lower and upper bounds for the blow-up times to
a system of semilinear stochastic partial differential equations given
by
du=[(Δ+V)u(t,x)+u(t,x)+u(t,x)]dt+ku(t,x)dW
du=[(Δ+V)u(t,x)+u(t,x)+u(t,x)]dt+ku(t,x)dW
where m,n,p,q are constants. Under the assumption that m ≥ n ≥ p ≥ q ≥
1, the distribution functions of several explosion times are obtained by
using explicit solutions of an associated system of random partial
differential equations and a formula due to Yor.
Effects berberine–silymarin on liver enzymes: A systematic review and meta-analysis of randomized controlled trials
Authors: Mohtashaminia Fatemeh , Amini Mohammad Reza , Shab-Bidar Sakineh , djafarian kurosh
Published: January 2024

ABSTRACT Objectives: Despite controversies, no study has systematically
summarized findings from earlier studies on the effect of berberine
(BBR)–silymarin on liver enzymes. Therefore, the current systematic
review and meta-analysis aimed to investigate the effect of berberis
aristate and silybum marianum on alanine aminotransferase (ALT) and
aspartate aminotransferase (AST) in adults. Methods: Relevant studies,
published up to June 2020, were searched through PubMed/Medline, Scopus,
ISI Web of Science, EMBASE and Google Scholar. The mean differences and
standard deviations were pooled using a random-effects model. The
studies’ quality was evaluated using Cochrane Risk of Bias Tool. Out of
80 citations, 5 trials that enrolled 549 participants were included.
Results: Berberis aristate and silybum marianum resulted in no
statistically significant change in ALT (weighted mean differences
(WMD): −0.39 mg/dl; 95% CI: −1.67 to 0.89, P=0.55), and AST (WMD: −0.44
mg/dl; 95% CI: −2.02 to 1.14, P=0.58). We did not find any significant
reduction in liver enzymes following BBR–silymarin consumption in
adults. Conclusion: Further clinical trials with high quality according
to challenges mentioned seem to be helpful to use BBR–silymarin as a
supplement for improving liver function. Keywords: Berberis aristate,
Silybum marianum, ALT, AST, Meta-analysis
On an open problem of Liu, Ouyang and Zhang
Authors: Li Gui-Dong , Li Yong-Yong , Tang Chunlei
Published: January 2024

In this paper, we investigate the following
Chern-Simons-Schr\”{o}dinger system
\begin{equation*} -\Delta
u+u+\left(\int_{|x|}^{\infty}
\frac{h(s)}{s} u^{2}(s) d
s+\frac{h^{2}(|x|)}{|x|^{2}}\right)
u=f(u) \quad \text { in }
\mathbb{R}^{2}, \end{equation*}
where $h(s)=\int_{0}^{s}
\frac{t}{2} u^{2}(t) dt$ and the nonlinearity
$f\in C(\mathbb{R},
\mathbb{R})$ satisfies the Ambrosetti-Rabinowitz type
condition. By using a combination of invariant sets method and the
Ljusternik-Schnirelman type minimax method, we prove the existence of
infinitely many sign-changing solutions. It is worth mentioning that the
nonlinear term may not be 5-superlinear at infinity. In particular, it
includes the power-type nonlinearity
$|u|^{p-2}u$ with $p\in (4,
\infty)$. This work also answers the open problem raised
by Liu, Ouyang and Zhang (Nonlinearity \textbf{32}
(2019), 3082-3111).
Ablation of accessory pathway connecting right atrial appendage and right ventricular outflow tract facilitated by computed tomography.
Authors: Derejko Paweł , Bardyszewski Aleksander , Kuśnierz Jacek , Dzwonkowska Dobromiła , Polańska Magdalena , Kidziński Rafał
Published: January 2024

The existence of accessory pathways connecting right atrial appendage
(RAA) and right ventricular outflow tract (RVOT) is well established. We
present a case where an accessory pathway of this type mimicked
parahisian pathway. Ultimately, preprocedural computed tomography (CT)
was helpful in planning the procedure and accomplishing successful
ablation after a failed attempt.
Severe Bleeding After Operation of Preauricular Fistula: A Case Report
Authors: Tian Chunhui , Chen Xiaojuan , Hao Zhongping
Published: January 2024

Severe bleeding after preauricular fistula with dyspnea is very rare,
and serious cases can be life-threatening, so it should be detected in
time and treated correctly.
Sensitivity analysis of pesticide dose on predator-prey system with a prey refuge
Authors: Hou Xiaoyu , Zhang Tonghua , Cheng Huidong
Published: January 2024

A type of predator-prey model with refuge and nonlinear pulse feedback
control is established. First, we construct the Poincaré map of the
model and analyse its main properties. Then based on the Poincaré map,
we explore the existence, uniqueness and global stability of the order-1
periodic solution, and also the existence of order-k(k ≥2) periodic
solutions of the system. These theoretical analysis gives the
relationship between pesticide dosage and spraying cycle and economic
threshold, and the relationship between the pesticide dose D and
threshold ET. The results show that choosing the appropriate spraying
period and finding the corresponding pesticide dose under the certain
economic threshold can control the number of pests and the healthy
growth of crops could be controlled. Moreover, we study the influence of
refuge on population density. The results show that with the increase of
refuge intensity, the population of predators decreases or even becomes
extinct. The parameter sensitivity analysis shows that the change of
control parameters and pesticide dosage is very sensitive to the
critical condition of the stability of the boundary periodic solution.
Discovery of Hysteresis Models Through the Symmetry Principle
Authors: DIATTA BASSIROU , Soh Celestin Wafo , Mahomed Fazal
Published: January 2024

We employ the symmetry principle to obtain rate-independent hysteresis
operators associated with a nonlinear diffusion equation. The direct Lie
approach to this problem leads to an overdetermined system of equations
for symmetries that are extremely difficult to analyze. To mitigate this
problem, we employ the classification of low-dimensional Lie algebra
following the suggestion of Lahno \textit{et al.}
(Journal of Physics A: Mathematical and General
\textbf{32} (42) (1999): 7405). After excluding linear
models, we obtain a one-dimensional principal symmetry Lie algebra,
seven symmetry Lie algebras of dimension two, twenty-six symmetry Lie
algebras of dimension three, and two symmetry Lie algebras of dimension
four. The curves of invariant solutions for symmetry Lie algebras of
dimensions three and four are exhibited in three forms. Under
appropriate selection of parameters, all invariant solutions show
one-to-many relationships between inputs and outputs, except for one in
dimension three.
A TRENDING STUDY ON THE NEUTROSOPHICATION OF Z - TRANSFORM
Authors: R POORNIMA
Published: January 2024

The present study focuses on the neutrosophication of Z - Transform , it
is developed and various properties like neutrosophic Z - Transform
linearity, neutrosophic Z - Transform damping rule, neutrosophic Z -
Transform shifting theorem, neutrosophic Z - Transform’s initial and
final value theorem are discussed under this method.The results of the
properties are proposed and numerical example have been illustrated.
A hybrid finite difference scheme for turning-point parabolic functional differential equations with discontinuous coefficients and source
Authors: Kaushik Aditya , sharma Nitika
Published: January 2024

The paper presents a hybrid finite difference scheme to solve a
singularly perturbed parabolic functional differential equation with
discontinuous coefficients and source. The simultaneous presence of
deviating argument with a discontinuous source and coefficients makes
the problem stiff. The solution of the problem exhibits turning point
behaviour across discontinuities as ε tends to zero. The hybrid scheme
presented is a composition of a central difference scheme in the layer
region on a specially generated mesh and a midpoint upwind scheme
outside the layer region. At the same time, an implicit finite
difference scheme is used to discretize the time variable. The proposed
numerical method has been analyzed for consistency, stability, and
convergence. The proposed method converges uniformly independent of the
perturbation parameter. Numerical results have been presented for two
test examples that demonstrate the effectiveness of the scheme.
Association of Neonatal Birth weight and neonatal sepsis along with pathogen distribution in Karachi population
Authors: kanwal summayya , younus Ishrat , Raza Liaquat
Published: January 2024

Background neonatal mortality rates are high in infants with low or very
low birth weight (VLBW) as they are prone to sepsis .Early onset sepsis
(EOS) that occur at 48hr of life remains an important cause of illness
and death in VLBW infants. Objective of the study is to analyze
association of Neonatal birth weight and neonatal sepsis in Karachi
population and to study their pathogen distribution in positive
isolates. Methodology a prospective cross-sectional study took place in
Karachi leading hospitals Darul sehat hospital and Abdus Samad hospital
neonatal birth weight and neonatal blood culture sensitivity test were
studied for positive sepsis .data were analyzed using SPSS applying Chi
square test Results out of 120 neonate’s blood culture sensitivity test
12 neonates had positive sepsis. Weight of 6 neonates out of 12 positive
was 2.1-3kg and other 6 neonates weight was 3kg. 3 isolates were
streptococcus pneumonia and 9 were staphylococcus aureus. Conclusion
Infants with positive sepsis are of healthy weights. Therefore, results
found to have no significant relation in between neonatal birth weight
and neonatal sepsis .EOS remains an uncommon yet important cause of
morbidity and mortality among VLBW infants.
Urbanization delays plant leaf senescence and extends growing season length in cold, but not in warm, areas
Authors: Li Daijiang , Stucky Brian , Baiser Benjamin , Guralnick Robert
Published: January 2024

Urbanization is quickly becoming one of the most important drivers of
global environmental change as human population and economic development
rapidly increase. However, the effects of urbanization on plant
phenology, especially leaf senescence and the length of growing season
across large spatial scales, are still understudied. Previous work
suggested that urbanization advances leaf-out in cold regions but delays
it in warm regions. We thus hypothesize that the effects of urbanization
on leaf senescence, and consequently the length of growing season, are
also dependent on climate context. Both in situ observations and remote
sensing-based phenological datasets strongly supported our hypothesis.
Specifically, we found that urbanization delayed leaf senescence and
extended growing season length in cold regions. However, urbanization
advanced leaf senescence and shortened growing season length in warm
regions, implying the positive effects of urbanization on growing season
length in cold regions may be weaker in a warmer future.
A direct comparison of ecological theories for predicting the relationship between plant traits and growth
Authors: Goud Ellie , Agrawal Anurag , Sparks Jed
Published: January 2024

Despite long-standing theory for classifying plant ecological
strategies, limited data directly links organismal traits to whole-plant
growth. We compared trait-growth relationships based on three prominent
theories: growth analysis, Grime’s CSR triangle, and the leaf economics
spectrum (LES). Under these schemes, growth is hypothesized to be
predicted by traits related to biomass investments, leaf structure or
gas exchange, respectively. In phylogenetic analyses of 30 diverse
milkweeds (Asclepias spp.) and 21 morphological and ecophysiological
traits, growth rate varied 50-fold and was best predicted by growth
analysis and CSR traits, as well as total leaf area and plant height.
Despite two LES traits correlating with growth, they contradicted
predictions and leaf traits did not scale with root and stem
characteristics. Thus, although combining leaf traits and whole-plant
allocation best predicts growth, when destructive measures are not
feasible, we suggest total leaf area and plant height, or
easy-to-measure traits associated with the CSR classification.
New Approach of Modifying Laplace Transform Variational Iteration Method to solve Fourth-Order Fractional Integro-Differential Equations
Authors: Hailat Ibrahim , Zainuddin Zarita , Azmi Amirah
Published: January 2024

In this paper, nonlinear boundary value problems for fourth-order
fractional integro-differential equations are solved by modified Laplace
transform variational iteration method (MLT-VIM). This modification is
designed to improve the accuracy of the approximate solutions obtained
by LT-VIM. The suitable initial approximation will be selected based on
a rule or standard to adjust the determination of the initial guess that
satisfies the boundary conditions. Furthermore, the residual error will
be cancelled at several points of the appropriate interval. The
convergence conditions of the proposed method are investigated. Some
illustrative examples of nonlinear boundary value problems for
fourth-order fractional integro-differential equations are presented in
order to demonstrate the effectiveness of the proposed method.
Comparisons are made between the results obtained by MLT-VIM and LT-VIM
depending on the exact solutions, revealing that the MLT-HPM contributes
to reduce the amount of computational work to obtain the first-order
approximate solution which greatly accelerates the convergence of the
solution. Whereas LT-HPM needs more iterations to obtain a suitable
approximate solution, which results in an increase in the computational
workload.