bluuebunny/crossref_metadata_2025 huggingface dataset:
ANADOLU’DAKİ BİR GRUP ANTİK ROMA YOLU
Authors: Altun Sinan
Published: September 2024

Yollarıyla ünlü olan Roma İmparatorluğu, ulaşım için önceliği her zaman deniz taşımacılığına vermiştir. Bunun başlıca nedeni, ilkin maliyet, daha sonra ise kara yoluyla ulaşıma kıyasla kolaylıktır. Ayrıca fazla miktarda ürünü tek seferde nakletmeyi de olası kılmaktadır. Ancak, deniz taşımacılığı mevsim koşullarıyla paralel kullanım sağlamaktadır. Bunun yanı sıra iç kesimlerde de çok sayıda yerleşim bulunmaktadır ve bunların da gereksinimlerini karşılamak gerekmektedir. Bu durumda kaçınılmaz olarak kara ulaşımı tercih edilmektedir. Antik dönemde kentler arasında bulunan karasal bağlantıların varlığı, İ.Ö. 7. yüzyıldan itibaren ele geçen destekleyici materyal kanıtlar sayesinde bilinmektedir. Roma İmparatorluğu’nu büyük hale getiren siyasi, mimari ve ticari etkenler belirleyicidir fakat bu etkenler yanında, yönetimin imparatorluk çapında uyguladığı yol politikası da imparatorluğun büyümesi ve büyüklüğünü koruması noktasında önemli role sahiptir. Asya ile Avrupa arasında doğal bir köprü işlevi gören Anadolu, Roma İmparatorluğu tarafından, bu topraklarda Roma egemenliğinin kurulması ve sürdürülmesi kapsamında kimi zaman sıfırdan inşa edilerek kimi zaman ise halihazırdaki yolların olabildiğince ve elbette ihtiyaca yönelik olarak bakım/onarım ve tamiri çalışmalarının yapılması yoluyla kontrol altında tutulmak istenmiştir. Buna yönelik uygulamalar da Roma’nın görevlendirdiği valiler eliyle gerçekleştirilmiştir. Bunlardan en bilineni Asia’daki miltaşlarında adına en sık rastlanılan kişi Asia legatusu Manius Aquillius’tur. Anadolu’nun kuzeyinde, ortasında ve doğusunda bulunan çeşitli yollar öncelikle askeri nedenler göz önünde bulundurularak yapılmıştır. Bu inşa süreci, İmparator Augustus ile başlamış ve Flaviuslar hanedanı ile en üst noktasına ulaşmıştır. Bu yol politikasına bir bakış atmaya çalışan bu makalede, bölgeler bazında Anadolu’daki Roma yolları ele alınmaya çalışılmıştır. Asia’da Via Sebaste imparatorluk eliyle biçimlendirilen ve adlandırılan iki önemli yolu içerir. Roma kentinden başlayıp, Perinthos’a kadar uzanan Via Egnatia ise inşa edildiği tarihte, Roma İmparatorluğu tarafından İtalya dışında yapılan ilk büyük yol olarak öne çıkmaktadır. Anadolu’daki antik yol kalıntılarının ardından en önemli veriyi miltaşlarının oluşturduğunu söylemek doğru sayılır; zira miltaşları, yol konusundaki tarihleme ve seyir açısından önemli veriler vermektedir.
Human post-mortem nuclei preparation and single-nucleus multiome DNA/RNA sequencing by ResolveOME v1
Authors: Kalef-Ezra Ester
Published: September 2024

Here we describe a protocol for nuclei isolation, immunostaining and sorting (FANS: Fluorescence-activated nuclear sorting) for single-nucleus DNA/RNA-seq using ResolveOME (BioSkryB) method from human post-mortem brain samples. We have used it to isolate nuclei from human post-mortem substantia nigra tissue, but it can be adapted for nuclei from different body areas. The ResolveOME protocol is generally designed to work with single live mammalian cells and here we have done minor modifications in order to use it for human post-mortem brain samples.
EVALUACIÓN DEL DESEMPEÑO MECÁNICO DEL MÁRMOL SINTÉTICO BASADO EN MATERIALES COMPUESTOS POLIÉSTER – CARBONATO DE CALCIO
Authors: Posada Piedrahita Jonathan Andrés , Herrera Jorge Mario , Trujillo Camacho Rosario , López Gómez María Esperanza , Pérez Pérez León Darío
Published: September 2024

Los materiales compuestos basados en resinas de poliéster y carbonato de calcio son promisorios para la sustitución del mármol natural en varias aplicaciones tales como instalaciones sanitarias y decorativas. En el presente trabajo se evaluó las propiedades mecánicas de materiales compuestos de resina poliéster con diferentes contenidos de carbonato de calcio (5, 10, 15, 20, 25 y 30%). Se encontró que existe una estrecha dependencia entre la composición de las muestras y sus propiedades de resistencia a la tracción. Se determinó que a contenidos de carbonato de calcio superiores al 15% el material es completamente rígido. Alrededor de esta concentración se encuentra el límite de percolación mecánica del relleno en este tipo de materiales compuestos. La resistencia al impacto incrementó con la adición de relleno aun a concentraciones superiores a su límite de percolación, lo cual puede deberse a que la ruptura de la red de relleno absorbe parte de la energía que suministra el impacto.
MECANISMO DE DESVITRIFICACIÓN NO-ISOTÉRMICA DE UNA ALEACIÓN
Authors: Obando Chacón Jorge , Rosales Rivera Andrés , Minotas Ruiz Julio , Echavarría Velásquez Alejandro
Published: September 2024

Los vidrios metálicos del tipo FeSiB exhiben características magnéticas blandas que los hacen atractivos para núcleos de transformadores, por sus bajas pérdidas por histéresis. Las muestras amorfas de aleación Fe   0,75Si0,15B0,10 se obtuvieron por Melt spinning, en la Universidad de Antioquia, pionera en Colombia en la implementación de esta técnica. Las muestras cristalinas se obtuvieron a partir de las muestras amorfas por un tratamiento isotérmico a 600 °C durante una hora. Tanto las muestras amorfa y cristalina fueron evaluadas por las técnicas XRD, TGA, y VSM (magnetometría vibrante). El material amorfo mostró nula cristalinidad y su curva de histéresis muestra que es magnéticamente blando. Por otro lado, las muestras cristalinas exhiben mayor pérdidas por histéresis. El mecanismo propuesto de la transformación amorfa  cristalina en condiciones no isotérmicas, evidenciado por el ensayo DSC, plantea una secuencia de tres pasos: En la primera etapa se forman dos fases amorfas activadas (sin liberación apreciable de calor), una rica en silicio, la otra rica en boro, vía una reacción de primer orden, con un parámetro cinético k0. A medida que transcurre el calentamiento la fase rica en silicio precipita una primera fase cristalina, solución sólida de silicio en hierro, I(Fe,Si), con estructura BCC, a temperaturas desde 520 a 540 °C, mediante el parámetro k1. Después, la fase rica en boro precipita simultáneamente el compuesto Fe2B y termina la precipitación de II(Fe,Si), vía el parámetro cinético k2. Estos dos últimos eventos son exotérmicos y se correlacionan a los respectivos picos del diagrama DSC. La fracción en masa del compuesto Fe2B se deduce estequiométricamente de la aleación. A partir de los datos experimentales se deduce el calor de cristalización promedio de la fase (Fe,Si). El mecanismo se aplica relativamente bien a tres composiciones Fe, Si, B cercanas a la obtenida en este estudio, extraídas de la bibliografía, corroborando los resultados obtenidos. Se plantea una interpretación del calor de cristalización a partir de los datos de entalpía de mezclado y la capacidad calórica de las aleaciones Fe-Si.
ESTUDIOS PRELIMINARES DE LA BIOMASA SECA DE EICHHORNIA CRASSIPES COMO ADSORBENTE DE PLOMO Y CROMO EN AGUAS
Authors: Atehortua Elizabeth , Gartner Carmiña
Published: September 2024

La Eichornia crassipes también conocida como jacinto acuático o buchón de agua, es una planta común en las fuentes de agua potable. Debido a su reproducción desmedida ha llegado a causar serios problemas en embalses y ríos porque genera eutroficación afectando la supervivencia de otras especies acuáticas y la navegación. Sin embargo se ha encontrado que esta planta puede ser también benéfica pues se ha utilizado en procesos de fitorremediación por su carácter altamente hidrofílico que la convierte en un buen adsorbente. Además su biomasa seca puede utilizarse en productos artesanales o para la generación de biocombustibles. En esta investigación se estudia la planta seca y triturada como material adsorbente de metales pesados en aguas residuales, específicamente de plomo y cromo. Se encontró que este material es un adsorbente eficaz de metales pesados dado que pudo adsorber plomo y cromo de soluciones. Se concluye que la biomasa de la E. crassipes puede ser usada eficientemente como material adsorbente para descontaminación de aguas residuales.
PREPARACIÓN DE SOPORTES DE QUITOSANO-GELATINA PARA SU APLICACIÓN EN LA INGENIERÍA DE TEJIDOS
Authors: Cañas Ana Isabel , Gartner Carmiña
Published: September 2024

El quitosano y la gelatina son biopolímeros promisorios para la elaboración de soportes celulares, debido a sus propiedades de biocompatibilidad, biodegradabilidad y su semejanza con la matriz extracelular de los tejidos de la piel, cartílago y hueso. En el presente estudio se prepararon soportes de quitosano y gelatina mediante liofilización para su uso en ingeniería de tejidos. Estos soportes se reticularon con 2,5-dimetoxi-2,5-dihidrofurano (DHF) usando las siguientes proporciones de gelatina: 0, 25, 50 y 100% (p/p), con el fin de estudiar comparativamente sus propiedades y a su vez compararlos con soportes no reticulados. Su morfología y porosidad fueron estudiadas por microscopía electrónica de barrido (SEM) y mediante ensayos de compresión se estudiaron las propiedades mecánicas. Se encontró que el módulo elástico aumentó con la concentración de DHF y también con el incremento de la concentración de gelatina. La técnica de liofilización permitió un buen control de la morfología de los soportes y se obtuvo una porosidad entre 40 y 160m, presentando un sistema de poros interconectados.
INFLUENCIA DE LA MICROESTRUCTURA EN EL COMPORTAMIENTO MECÁNICO DE METALES CELULARES BASE ALUMINIO
Authors: Fernández Morales Patricia
Published: September 2024

Los metales celulares son materiales innovadores con gran potencial de aplicación en diversos sectores (automotriz, aeronáutico, procesos térmicos, etc), y de ahí la importancia de indagar acerca de sus propiedades, las cuales, son directamente influenciadas por la propia estructura porosa del metal celular. Adicional a lo anterior, la microestructura del metal propio de la matriz puede llegar a contribuir directamente en las propiedades, tanto físicas y químicas, como mecánicas. En el presente artículo, se analizó el comportamiento mecánico de esponjas metálicas (metales celulares de porosidad abierta) bajo esfuerzos de deformación a compresión y la influencia tanto de la estructura porosa como de la microestructura de la aleación de aluminio. Para lograr lo anterior, se inició con el análisis morfológico y estructural mediante microscopia SEM de las esponjas de aluminio, se obtuvo la densidad relativa, y luego se procedió a realizar ensayos de compresión a probetas cilíndricas.
Navigating Social Boundaries and Belonging: People Without Migration Background in Majority–Minority Cities
Authors: Waldring Ismintha , Crul Maurice , Lelie Frans
Published: September 2024

This editorial introduces the articles in this thematic issue, which revolves around the ERC Advanced research project Becoming a Minority (BaM), carried out between 2018 and 2023. The aim of the project was to understand how people without a migration background think about and live in diversity. Through this aim, the BaM project has tried to advance our thinking about the concept of integration.
Building a General Algorithm for Seismic Hazard Analysis in the Sunda Arc through Geodynamic Simulations
Authors: Triyoso Wahyu , Rosalia Shindy , Grandis Hendra
Published: September 2024

Because of its well-documented subduction zone and outer island arc, Sumatra provides a unique setting for studying and forecasting earthquakes within the seismically active Sunda Arc. This study builds on previous research that utilized Global Positioning System data and the Akaike information criterion to analyze probabilistic seismic hazard functions. However, this study replaces surface displacement rate data with a forward model derived from previous fault modeling results to create a more broadly applicable earthquake forecasting algorithm. Although the best-fit model patterns generated by this new algorithm are consistent with past studies, the forward model demonstrates a lower degree of fit compared to models utilizing natural surface displacement data. This discrepancy highlights the need to refine the fault parameter models to estimate surface displacement rates. Despite this limitation, the study makes a valuable contribution by developing a general algorithm applicable to other subduction zones within the Sunda Arc region. With further refinement and incorporation of more accurate fault modeling and data, this algorithm has the potential to formulate the best-fit earthquake spatial forecast models. This approach could be applied to other seismically active areas, particularly those near subduction zones.
A Review of 15 Years of Public Earthquake Forecasting in Aotearoa New Zealand
Authors: Gerstenberger Matthew C. , Christophersen Annemarie , Rhoades David A.
Published: September 2024

New Zealand entered a period of increased seismic activity in 2003, which, to date, has included around 20 large or damaging earthquakes. Building on decades of forecast model research and including research into formal model evaluation, GNS Science, the governmental institution tasked with providing natural hazards information, began issuing public earthquake forecasts following the 2009 Mw 7.2 Darfield earthquake. This article provides a review of the public earthquake forecasting methods and outcomes since that time. Initially the release of forecasts was motivated by the scientific team, but interest, use and understanding quickly rose in the public, government, and private sectors which led to regular refinement and additions to the type of forecast information provided. The basic tenet of forecasting has remained the same, with the forecasts being used to inform decisions requiring consideration of timeframes from days to decades. The operational models were all based on the previous 10–20 years of research in model development and testing; this included the development of methods for combining multiple models into a single hybrid model that typically provides increased statistical forecast skill. The hybrid models combine models from three classes of time horizons: (1) short-term aftershock clustering based on the epidemic-type aftershock sequence class of models, (2) medium-term clustering with time horizons of years to decades, and (3) long-term models with time horizons of decades to nominally time independent. Forecasts have been issued in response to 14 large or significant earthquakes with the forecasts and accompanying information regularly updated on the GeoNet webpages. An important component to the successful deployment and uptake of the models was the foundation laid in the previous decades in model development and testing. This provided understanding and confidence in the models’ ability to provide useful forecasts for response and recovery decisions.
USING THE INTEGRALITY PRINCIPLE IN MODERN EDUCATIONAL TECHNOLOGIES
Authors: Иванова О.В. , Сбитнева Н.Н.
Published: September 2024

В статье подчеркивается актуальность обучения в вузе на основе принципа интегральности. Авторы характеризуют существующие интегральные технологии, анализируют принципы и методы интегральной педагогики и на основе имеющегося опыта из учебной практики предлагают собственную интегративную модель обучения в вузе, которая в максимальной степени соответствует гуманистической парадигме современного образования и учитывает многообразие факторов обучения в вузе. В разработанной авторами «модели интегративного обучения в вузе» целостная личность и целостный учебный процесс выступают в качестве интегрального результата, а сама педагогика предстает интегральной наукой.

The article emphasizes the relevance of learning based on the principle of integrality. The authors characterize the existing integrated technologies, analyze the principles and methods of integrated pedagogy, and on the basis of educational practice experience propose their own integrative model of higher education. This model is in line with the humanistic paradigm of modern education and takes into account the diversity of factors of university education. In the model developed by the authors, the integral personality and the holistic educational process act as an integral result, and the pedagogy itself becomes an integral science.
PEDAGOGICAL SUPPORT FOR FOREIGN STUDENTS IN EXTRACURRICULAR TIME
Authors: Козлова М.А.
Published: September 2024

Важным условием успешной социокультурной адаптации иностранных студентов к обучению в российских вузах является педагогическое сопровождение. В статье рассматривается педагогическое сопровождение обучения иностранных студентов во внеучебное время, исследуется потенциал внеучебной деятельности в поддержке и адаптации иностранных студентов. Показаны особенности наставнической деятельности педагога-куратора во внеучебное время.

Pedagogical support is an important condition for successful socio-cultural adaptation of foreign students to studying at Russian universities. The article considers pedagogical support of teaching foreign students in extracurricular hours, examines the potential of extracurricular activities in support and adaptation of foreign students. The features of tutor’s mentoring activity in extracurricular hours are shown.
Online Collaborative Testing: Design and Implementation in a Large First-Year Undergraduate Course
Authors: Miller Mariel , Askari Safoura , Qudsia Syed
Published: September 2024

Online collaborative testing is an approach to assessment that emphasizes technology-mediated learning through interaction with peers. As the COVID-19 pandemic prompted exponential growth in online teamwork, skills for online collaborative problem-solving have become essential for today’s graduates. As such, online collaborative testing can play a crucial role in supporting students to develop these skills. In this paper, we report on how an online collaborative test was implemented in a large first-year undergraduate course. We begin with a review of the literature on online collaborative testing. We then describe how the instructional team designed and administered a synchronous online collaborative midterm exam in which groups worked together to analyze a complex case scenario. Finally, we conclude with a reflection on the strengths and limitations of our approach and opportunities for future design.
Improving Student's Vocabulary Skill Through Contextual Teaching and Learning (CTL) Method At The Nineth Years Student's of Pondok Pesantren Salafiyah Wustho An Nimah Batam
Authors: Regandi Angga , Edi Warno , Adam
Published: September 2024

This thesis discusses about Improving students' vocabulary skills through contextual learning (CTL) in ninth grade students of Pondok Pesantren Salafiyah Wustho An Nimah Islamic. The formulation of the problem in this study is "The effectiveness and perception of students in the use of contextual learning (CTL) to improve students' vocabulary. The goal of this study is to determine whether the use of contextual learning (CTL) can improve students' vocabulary skill and also students' perceptions in teaching vocabulary through CTL. This study uses a pre-experimental method with post-test. This study aims to reveal or describe systematically based on data that has been collected from the pre-experimental study. The target population of this study were all ninth grade students of Salafiyah Wustho An Nimah Pondok Pesantren in 2023/2024 year. The sample was taken from the population using purposive sampling and from the lower class and the number of sample were 23 students. The instruments of this study were vocabulary tests and questionnaires. The vocabulary test was given to which students understood the material given and the questionnaire was to determine students' perceptions. The results of the analysis show a significant difference between before and after giving treatment through the CTL method in improving vocabulary skills. Based on the results of the analysis, it can be concluded that the CTL method is effective in improving the vocabulary skills of class IX students of the Pondok Pesantren Salafiyah Wustho An Nimah.
Herri-politiken eraldaketa errazteko artea
Authors:   Universidad de Deusto, Larrea Miren
Published: September 2024

Egungo erronka ekologiko, politiko eta sozialei aurre egiteko politika publikoak eraldatzeko beharrari heltzen dio liburuak, eta ekintza-ikerketa funtsezko metodologia gisa proposatzen du. Metodologia hori lankidetzan eta ezagutzaren garapenean oinarritzen da, gobernuen eta lurraldeko beste eragile batzuen arteko baterako ekintzaren bidez. Helburu nagusia ikerketa operatiboa errazteko metodologiak hobetzea da, horrela politika publikoak benetan eraldatzen laguntzeko. Hamabost urteko esperientzian oinarrituta, liburuaren egileak ibilbide pertsonala ez dela azaltzen du, herri-politiketan aldaketa-prozesuak errazteko talde-lanari buruzko gogoeta bat baizik, aldaketa horiek geldiarazi dituzten pentsamendu-banaketak gaindituz. Praktikaren bidez eskuratutako ezagutza intuitiboaren garrantzia nabarmentzen du egileak, eta ezagutza hori, arrazionalki azaltzen zaila izan arren, politika publikoak errazteko funtsezkoa dela. Bere esperientzia pertsonala erabiliz, egileak intuizioak eta emozioek erraztasun-prozesuetan erabakiak hartzeko funtsezko zeregina nola betetzen duten aztertzen du. Ekintza-ikerketaren hainbat alderdiri buruzko kapituluen bidez, egileak pentsamendu-zatiketak nola gainditu erakusten du, eta elkarlanerako, hausnarketarako eta baterako ekintzarako ikuspegia proposatzen du. Gainera, liburuak elementu artistikoak biltzen ditu, hala nola marrazkiak, prozesu horietan bizitako esperientziak eta inplikatutako emozioak adierazten eta ulertzen laguntzen dutenak, politika publikoak eraldatzen laguntzeko lanaren dimentsio subjektiboa eta emozionala nabarmenduz.
Violation of International Law Within the Framework of Attempts at Preservation of Global Domination
Authors:   Vice-Rector for Research of the Diplomatic Academy of the Ministry of Foreign Affairs of the Russian Federation, Karpovich Oleg G.
Published: September 2024

The Ukrainian conflict has triggered serious changes in the systems of strategic security, political and economic world order. Serious changes are taking place in the geopolitical picture of the world. The emergence of a polycentric world is a fundamentally new system of world order, the idea of which is extremely painfully perceived by Western countries, accustomed to consider themselves the center of human civilization since at least the colonial era. It is now obvious that many countries of the "global South", having recovered from the consequences of the colonial era in several decades, want to act in the international arena in their own, and not in Western national interests, based solely on international law and the UN Charter.
Instruments of Legal Protection of Intellectual Property in Carrying out Foreign Trade Activities
Authors:   Professor of the Department of Private International Law and the Department of Intellectual Rights of the Kutafin Moscow State Law University, Shakhnazarov Beniamin A. , Bliznets Ivan A. ,   Member of the Russian Academy of Natural Sciences, Head of the Department of Intellectual Property of the A.S. Griboyedov Moscow University
Published: September 2024

The article reviews special aspects of protection of intellectual property. The authors analyze approaches of some countries to protection of certain IP items, legal regimes. The paper highlights that it is reasonable to take into account cultural, linguistic aspects of the respective state, mindset of the local population in carrying out export activities. The paper studies special aspects of license agreements entered into in carrying out export activities. It is noted that recent evolution of information and communications technologies has substantially improved opportunities of control over outsourced activities or processes whether in one or several remote national or international locations, which has made outsourcing a more attractive option of international activities in many other spheres. The article studies special aspects of the TRIPS Agreement that introduces not only procedural provisions of review of disputes including the ones associated with violation of rights to intellectual property that bind states, but also specific right protection mechanisms to be directly applied by courts of the states that are parties to the Agreement.
Racial Profiling in Japan: Always a Foreigner
Authors:   Senior Lecturer of the Department of Theory and History of State and Law of the Baikal State University, Kochetkova Irena V. , Kornakova Svetlana V. ,   Associate Professor of the Department of Theory and History of State and Law of the Baikal State University, Osipova Marina A. ,   Senior Lecturer of the Department of Theory and History of State and Law of the Baikal State University
Published: September 2024

Racial inequality and discriminatory practices continue to disrupt the lives of millions of people and limit their opportunities, significantly reducing their quality of life. Despite the adopted international and national documents, the issue is far from resolved. Racial profiling has long been under international scrutiny and is a major concern. This is a special type of discrimination that flourishes in developed countries, in which law enforcement agencies are directly involved. The police practice of racial profiling, in which people are targeted or criminalized based on factors such as nationality, skin color or ethnic origin rather than objective evidence or illegal behavior, has become a persistent problem in Japan. Japan is an ethnically homogeneous state, so the situation with racial profiling is particularly acute, but Japanese authorities in the vast majority of cases ignore or hush up this problem, giving the green light to the further development of ethnic discrimination and creating a negative attitude towards foreigners in Japanese society.
Exploring Promising Multi-targeted Drug Candidate for Alzheimer’s Disease from Compounds Based on Benzalaniline with 1,3,4-Oxadiazole Skeleton: An In Silico Modeling and Docking Study
Authors: K Rahul , Thamızhanban Devi , Narayanan Hariraj
Published: September 2024

In general, oxadiazole and benzalaniline derivatives have shown promising activity against a variety of diseases. Combining these two scaffolds into a single drug candidate is a strategy that has garnered increasing interest in multi-targeted drug discovery. This study aims to identify potential ligands from benzalaniline derivatives containing 1,3,4-oxadiazole, targeting various proteins associated with Alzheimer’s disease through molecular modeling and docking studies. In silico ADME screening was also performed to predict drug-likeness and blood-brain barrier (BBB) permeability, using the QikProp tool from the Schrodinger suit 2023-1 (Maestro 13.5.128). The crystallographic structure of the molecular targets was obtained from the PDB database, specifically Acetylcholinesterase (PDB ID: 4EY7), Butyrylcholinesterase (PDB ID: 4BDS), Monoamine Oxidase (PDB ID: 2V60), and BACE-1 (PDB ID: 7B1P). The designed ligands demonstrated strong affinity with key amino acid residues and their drug-likeness. Along with BBB permeability, it highlights their potential as inhibitors for these targets. In particular, chloro substitution on benzalaniline, combined with hydroxyl aromatic substitution on oxadiazole, exhibited favorable binding affinity with the four receptors selected for this study. A ligand with 3-Chloro and 3’-hydroxy substitution (R139) displayed a strong binding affinity for acetylcholinesterase, with a docking score of -10.247. When the chloro group was positioned at the second site (R114), it was more effective against butyrylcholinesterase, yielding a docking score of -7.723. Furthermore, a ligand with 3-chloro and 4’-hydroxy substitution showed a superior binding score (-10.545) with MAO-B. All proposed compounds fell within the acceptable ADME range (BBB permeability: QPPMDCK value >500; QPlog BB 3 to 1.2). Based on the data presented in this study, the suggested ligands should be considered as potential inhibitors.
Comparative efficacy of synthetic peptide, platelet-rich plasma, and hyaluronic acid alone or in combination in microfracture treatment of focal chondral defects
Authors: Pepele Demet , Akgün Erkan , Yılmaz Barış , Midi Ahmet , Akpolat Ahmet Onur
Published: September 2024

Aim: Although previous limited studies have evaluated the efficacy of adjuvants used alone or in combination to augment microfracture (MF) treatment for focal chondral defects, there are no studies comparing the outcomes of the synthetic peptide (SP) with other adjuvants such as platelet-rich plasma (PRP), hyaluronic acid (HA), or their combinations. This study aimed to evaluate whether the efficacy of MF treatment in focal chondral defects is influenced by the use of adjuvants either alone or in combination.
Material and Methods: Thirty-six rats were included in the study. Group 1 received MF alone, Group 2 received PRP after MF, Group 3 received HA after MF, Group 4 received a SP after MF, Group 5 received a SP plus PRP therapy after MF, and Group 6 received a SP plus HA therapy. The knees of the rats were assessed according to the International Cartilage Repair Society (ICRS) Cartilage Repair Assessment 1 (ICRS-1) and 2 (ICRS-2).
Results: The median ICRS-1 and ICRS-2 scores in Group 1 were lower compared to the other groups, while these scores in Group 2 and Group 4 were similar and higher than the other groups. Also, these scores in Group 5 and Group 6 were similar and lower compared to Group 3 (Group 1: 1 vs. Group 2: 12 vs. Group 3: 9 vs. Group 4: 11 vs. Group 5: 7 vs. Group 6: 7, p < 0.001 for ICRS-1 scores; Group 1: 0 vs. Group 2: 85 vs. Group 3: 70 vs. Group 4: 80 vs. Group 5: 45 vs. Group 6: 45, p < 0.001 for ICRS-2 scores).
Conclusion: In the MF treatment of focal chondral defects, SP, PRP, and HA injections have a beneficial adjuvant effect based on macroscopic and histopathological findings. However, the combination of these adjuvants is less beneficial than their individual usage.
The relationship between optic nerve sheath diameter and demographic and clinical findings in patients diagnosed with clinically isolated syndrome
Authors: Acır İbrahim , Yüksel Burcu , Soysal Aysun , Yayla Vildan
Published: September 2024

Aim: This study aimed to assess optic nerve sheath diameter (ONSD) levels in patients diagnosed with clinically isolated syndrome (CIS) who were being followed in the demyelinating diseases clinic, as well as to examine their relationship with demographic characteristics and clinical findings.
Material and Methods: In this cross-sectional prospective study, 14 patients diagnosed with CIS who underwent lumbar puncture for specific cerebrospinal fluid (CSF) analysis were included between January 2024 and August 2024. The ONSD were measured by transorbital sonography. All patients' demographic characteristics, clinical parameters (CSF protein, CSF albumin, serum albumin, immunoglobulin G index, and vitamin D) were recorded.
Results: The patients had a mean age of 39.4 ± 12.8 years, and the majority were women. Oligoclonal bands were positive in all patients. The mean disease duration was 23.5 ± 7.6 days. The ONSD measurements for all patients ranged between 3.1 and 5.9 mm in the sagittal and axial planes of both eyes. There was a strong negative correlation between ONSD levels and age, diseases duration, CSF protein, CSF albumin, serum albumin, and immunoglobulin G index.
Conclusion: This study demonstrated a significant relationship between ONSD and various clinical and laboratory parameters in patients diagnosed with CIS. These findings suggest that ONSD may serve as a valuable, non-invasive marker in assessing disease severity and progression in CIS patients.
DIREITOS DA SOCIOBIODIVERSIDADE E SUA FACE DECOLONIAL: uma proposta para além do pensamento abissal
Authors: Curvello Isabel Foletto , Tybusch Jerônimo Siqueira
Published: September 2024

Romper com o pensamento colonial. Esse é o pressuposto quando se fala em direitos da sociobiodiversidade. Desse modo, este artigo tem por foco analisar a relação inerente entre direitos da sociobiodiversidade e pensamento decolonial, partindo dos seguintes questionamentos: quais são as rupturas com o pensamento colonial que são necessárias para pensar em direitos da sociobiodiversidade e quais são as contribuições do pensamento decolonial nesse sentido. Para tanto, o artigo utiliza a pesquisa bibliográfica e a “dialética alternativa” dusseliana para explorar as contradições componentes da narrativa colonial. Ao fim, conclui que a sociobiodiversidade se fundamenta nos postulados do Grupo Modernidade/Colonialidade, sobretudo porque chama à possibilidade de imaginar outros mundos, para além do pensamento abissal constituído com a narrativa colonial.
Revolutionizing Garden Pea Yield: A Synergistic Strategy with Plant Extracts, Bio-control Agents and Fungicides for Root Rot Disease Management and Optimal Productivity
Authors: Nain Yogita , Chawla Nitin , Meena Priyanka Kumari , Sharma Ridhi Shankar , Choudhary Kiran , Rani Jyoti
Published: September 2024

Background: Pea, a vegetable crop cultivated in cooler regions globally, holds substantial economic significance in India. Unfortunately, root rot poses a significant challenge, especially during the early stages of plant growth, with Fusarium solani f. sp. pisi identified as the causative agent. To address this issue, a comprehensive study was conducted over two consecutive years, evaluating the efficacy of various plant extracts, bioagents and fungicides, both in field and laboratory settings, to control root rot in pea. Methods: A field experiment was conducted at Rajasthan Agricultural Research Institute, Jaipur in the Rabi seasons of 2021-22 and 2022-23 aimed to develop a sustainable strategy to gather valuable insights and observations throughout the growing seasons to combat root rot in pea crops, specifically using the susceptible variety Arkel. Result: Among all fungicides, plant extracts and bio-control agents that demonstrated efficacy in laboratory settings were subsequently evaluated in real-field conditions. In field condition seed treatment with tebuconazole 50%+ trifloxystrobin 25% at 0.1% along with soil application of neem cake at 5q/ha was found best with minimum disease incidence and maximum pod yield (75.80 q/ha). Among these treatments, neem cake was the most effective in reducing the incidence of root rot in peas compared to the application of mustard cake.
BIBLIOMETRIC ANALYSIS OF STATISTICAL DATA PROCESSING USING SPSS
Authors: Anastasya Diva Berta , Yuadi Imam
Published: September 2024

Background: This research is related to statistical data processing using SPSS (Statistical Package for Social Science). Statistics has several methods that can be used in research, especially in statistical data processing. One of the tools used for quantitative data analysis is SPSS. This article focuses on bibliometric analysis in determining the data to be reviewed.  Purpose: Analyze "Statistical Data Processing Using SPSS" through a search on the Web Of Science.  Method: Data search is done on Web Of Science, then bibliometric analysis is done using Biblioshiny.  Result: The final result through Biblioshiny of export in Bibtex format is a visualization of field category data based on keywords, publication level, regional distribution and several relevant document types. The results demonstrate the efficiency and accuracy of SPSS in data processing and help researchers understand the relationships between variables and make better data-driven decisions. It found 500 documents issued from 1991 to 2023. The annual growth was 13.14% with an average age of 6.08 years from each document.  Conclusion: It can be concluded that the opportunity to study statistical data processing using SPSS is more accurate, so readers can use SPSS as a quantitative research data testing tool.
Road Flood Warning Detection Using Wireless Sensors and Fuzzy Logic to Support Gresik Smart City
Authors: Frayudha Angga Debby
Published: September 2024

In this paper, we study how to overcome the urgency of flooding that occurs suddenly around the city of Gresik using wireless sensors with fuzzy logic to support Gresik smart city. The process of making flood alarm detection is very difficult to solve. To overcome this, we propose the use of wireless sensors using fuzzy logic in flood-prone areas. Fuzzy logic is used to process sensor data to find more accurate results to improve accuracy and efficiency. Two sensors are installed at the flood warning test point, using Wemos D1 MINI / NodeMCU so that the IoT network can be connected to the server. The data obtained from the measurement results are processed using fuzzy logic. Fuzzy will provide flood warnings automatically when the height is 30 cm and above. The method used is qualitative and product development research. The results after conducting 100 trials showed that there were six cases of errors in reading the water level, so that from the trial an error of 6% was obtained from the sensor made and a success accuracy of 94% was obtained. The research conducted concluded that the research results were as expected. In this way, public safety against sudden flood events will increase.
Iniciando a Programar con Python.
Authors: Cuervo Álvarez Javier Humberto , Cuervo Díaz Lina María , Cuervo Díaz Nathalia Andrea
Published: September 2024

"Iniciando a Programar con Python: Guía básica de programación" ofrece una introducción completa al lenguaje de programación Python. Comienza con una visión histórica y las ventajas de Python, para luego sumergirse en el proceso de instalación, que incluye Jupyter y Visual Studio Code. Cubre conceptos fundamentales de programación como identificadores, palabras clave, bloques de código, entrada/salida y comentarios. La sección sobre variables, constantes y tipos de datos explora números enteros, de punto flotante, booleanos, variables de texto, listas, conjuntos, tuplas y diccionarios. Presenta operadores, desde básicos hasta bit a bit.Luego se abordan las estructuras de control, funciones y módulos, con la exploración de temas como manejo de excepciones y bucles. También se discuten conceptos avanzados, como la programación orientada a objetos, matrices y variables globales/locales. El libro concluye con una exploración extensa de estructuras de datos, la cual cubre listas, conjuntos, tuplas y diccionarios en términos de características, operaciones y métodos. La última sección aborda la entrada/salida con archivos y abarca archivos de texto y binarios, manejo de archivos CSV y serialización de datos. Esta guía proporciona una base sólida para principiantes en Python. Va desde conceptos básicos hasta temas avanzados de programación y estructuras de datos.
Long-Term Management of Sleep Apnea-Hypopnea Syndrome: Efficacy and Challenges of Continuous Positive Airway Pressure Therapy
Authors: Gomez Coral Maria Isabel
Published: September 2024

Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS) is a prevalent condition characterized by intermittent upper airway obstruction during sleep, leading to significant health issues, including cardiovascular disease, metabolic syndrome, and neurodegenerative disorders. The primary treatment for OSAHS is Continuous Positive Airway Pressure (CPAP) therapy, which maintains airway patency through a continuous flow of air, effectively reducing apnea-hypopnea indices, improving sleep quality, and lowering cardiovascular risks.
Psychological Impact of Social Networking Sites on Indian Adolescents
Authors: Gupta Debajyoti
Published: September 2024

Social media plays an important role in our life. All the youths living in India and different parts of the world are engaged in social media platform they are busy in themselves to meet new people, make new friends and chat with them. It has been seen that not only young people but also old people are also engaged in social media platform. It is true that there are some merits and demerits in everything. Sometimes excessive use to social networking sites can cause a negative psychological impact on the minds of young people. This research paper will focus on the positive use of social networking sites, effect on the mind on the adolescents due to the excessive use of social networking sites and to suggest some solution to it. Social media has also caused some prominent changes in the attitudes and lifestyles of the adolescents.
Farklı Eğitim Seviyelerindeki Katılımcıların Sosyo-Kritik Matematiksel Modelleme Etkinliği Çözüm Süreçlerinin İncelenmesi
Authors: Yanar Amine Nur , Ergene Özkan
Published: September 2024

Bu araştırmanın amacı, farklı eğitim seviyelerindeki katılımcıların sosyo-kritik bir modelleme etkinliği çözüm süreçlerini modelleme yeterlikleri ve temsil kullanımı bağlamında incelemektir. Nitel araştırma yöntemlerinden durum çalışmasına uygun olarak yürütülen araştırmanın katılımcılarını anadolu ve fen lisesi öğrencileri, matematik öğretmeni adayları ve matematik öğretmenleri oluşturmaktadır. Araştırmanın verileri araştırmacılar tarafından tasarlanan geçerlik ve güvenirlik çalışmaları gerçekleştirilmiş ilaç kullanımına yönelik sosyal odaklı bir modelleme etkinliğiyle toplanmıştır. Katılımcıların çoğunun problemi anlama yeterliğinde yüksek başarı sergilediği, doğrulama basamağında ise güçlük yaşadıkları tespit edilmiştir. Tüm yeterlik düzeylerinde en yüksek başarıyı öğretmenlerin gösterdiği ve benzer şekilde öğretmen adaylarının, lise öğrencilerine göre yeterlik düzeylerinde daha yüksek başarı gösterdikleri bulgusuna varılmıştır. Modelleme etkinliği çözüm sürecinde en fazla sözel temsil, en az ise grafiksel temsil kullanıldığı sonucuna ulaşılmıştır. Araştırma sonunda katılımcıların eğitim seviyesi arttıkça modelleme yeterlik düzeylerinde daha yüksek performans gösterdiği sonucuna ulaşılmıştır. Katılımcıların büyük çoğunluğunun çözümlerinde tek bir temsil kullanımına yer verdiği ortaya çıkmıştır. Cebirsel temsil kullanımında en yüksek başarıyı öğretmen adaylarının gösterdiği, anadolu lisesi öğrencilerinin fen lisesi öğrencilerine ve öğretmen adaylarına göre tablo kullanımında daha başarılı olduğu bulgusuna varılmıştır. Lise öğrencileri, öğretmen adayları ve öğretmenlerin modelleme yeterliklerinin farklı bağlam içeren birden çok modelleme etkinlikleri ile karşılaştırmalı olarak incelenmesi bu araştırmanın önerileri olarak ön plana çıkmaktadır.
The Right to a Healthy Environment
Authors: Barus Sonia Ivana , Widiyarti Diyas
Published: September 2024

As a pivotal justice enforcement agency in Indonesia, the State Administrative Court (PTUN) is instrumental in protecting citizens' rights, particularly in cases where administrative decisions by state officials cause harm. This article critically analyzes the implications of this problem construct judge decisions, explicitly focusing on environmental destruction cases. The interpretation of legal provisions plays a decisive role in determining outcomes. However, explaining the background of rationality used by judges is still being debated among scholars. Through an in-depth examination of several judicial decisions, the study identifies significant inconsistencies in interpreting Article 53 Paragraph (1) of the Administrative Court Law, especially concerning the phrase' interests are harmed.' These inconsistencies undermine legal certainty and expose underlying sociological issues, including power imbalances and social inequality. Mainly, that disproportionately hinders vulnerable communities from accessing justice. The analysis suggests that if left unaddressed, these disparities could further erode the principle of equality before the law, a cornerstone of justice, and weaken the foundations of environmental justice in Indonesia. A systematic interpretation is used to develop alternatives to overcome the challenges arising from ecological rights. Based on the inconsistency of Article 53 Paragraph (1) interpretation, this article argues that harmonization with domestic laws and international environmental agreements is the legal foundation. Furthermore, this approach is essential for reinforcing the judiciary's role in upholding citizens' rights, ensuring equitable access to justice, and strengthening Indonesia's legal framework for environmental protection.
Keywords: Environment, Inconsistency, Justice, Rights, State Administrative Court
Community Policing Philosophy
Authors: Meini Bruno
Published: September 2024

A sociological understanding of crime can adequately respond to criminal challenges through practical engagement with society. Community policing is a proactive strategy that uses problem-solving methods and strategic partnerships to solve problems related to public safety, including crime and social disturbance. The core of this policing system is a flexible organizational structure and decentralized power, in which the officer decides how best to preserve security and order in line with local needs. Decentralized administration at both the command and decision-making levels has been used as an approach to promote the effectiveness of community policy. Consequently, police officers could independently interact with communities, identifying problems and developing feasible solutions. However, this idea has variations, particularly in the debate on how community policy can construct a social system to create better strategies against criminal acts. It is essential to analyze the sociological perspective to understand the main objective of the community-oriented policing strategy. Mainly, a theory that focuses on reducing crime and crime fear enhances the conditions of life for law enforcement personnel and members of society. Hence, this article analyses each strategy component using pertinent and specific sociological theories and criminological concepts, highlighting the significant contribution of sociologists in shaping the community policing strategy. Therefore, based on sociological perspectives, this article argues that community policy can create an inclusive social system within social actors’ collaboration.
 
Keywords: community-oriented, crime, neighborhood, sociological perspective, partnerships
20. Yüzyılda Mağrib’teki Arap Dilbilim Çalışmaları -Tunus Örneği
Authors: Kaya Esma , Çınar Mehmet Şirin
Published: September 2024

Ferdinand de Saussure ile başlayan dilbilimin Arap dil çalışmalarını önemli bir ölçüde etkisi altına aldığını söylemek mümkündür. Arap dünyasında dil çalışmaları eskiye dayanan bir gelenek olsa da Saussure’ün yapısalcı dilbilim metoduna yönelik ne yapacağı konusunda çeşitli yaklaşımlar benimsenmiştir. Arap dünyasında yapılan dil çalışmalarını kabaca Maşrik ve Mağrib’de yapılan çalışmalar olarak ikiye ayırmak mümkündür. Maşrik’te önceleri Kahire’de bulunan Alman Üniversitesi’ndeki dil çalışmalarına paralel bir şekilde karşılaştırmalı dilbilim çalışmalarıyla başlayıp ilerleyen zamanlarda ise Londra ekolünden olan Firth’in bakış açısıyla dilbilim çalışmaları yapılmıştır. Ayrıca Saussure’ün Genel Dilbilim Dersleri kitabının geç tercüme edilmesiyle beraber Maşrik’teki dilciler Saussure dilbilimini doğrudan ele almada gecikmişlerdir. Bu durum Maşrik’te birbiriyle çelişkili dil çalışmaları yapılmasıyla beraber pek çok soruna yol açmıştır. Mağrib bölgesinin Fransız sömürgesi altında olması nedeniyle buradaki dil çalışmaları Maşrik bölgesine göre daha geç bir dönemde başlamıştır. Bu bölgedeki ülkeler Fransız sömürgesinden kurtulduktan sonra Batıdaki dilbilime dayalı çalışmalar yapmaya başlamışlardır. Bu dönemde kurulan üniversiteler, dilbilim çalışmalarına olanak tanımış ve Fransızcanın yaygın olarak bilinmesi, dilcilerin Saussure dilbilimini doğrudan ele almasına olanak sağlamıştır. Bu yüzden Mağrib’deki dilbilim çalışmaları Maşrik’e göre daha geç bir dönemde yapılmış olsa da onlar Saussure’ün dilbilimini doğrudan ele almışlardır. Bu durum Maşrik’te yaşanan belirsizliklerin aksine Mağrib’de istikrarlı bir dilbilim çalışması ortamının oluşmasına katkı sağlamıştır. Bu makalede ilk olarak Arap dünyasındaki dilbilim faaliyetleri Maşrik ve Mağrib merkezli olarak ele alınacaktır. Daha sonra özellikle Mağrib bölgesindeki dilbilim araştırmaları üzerinde durulacak ve bu bölgede oluşan dil çalışmalarının temel özelliklerine yer verilecektir. Ayrıca Arap dilbilim çalışmaları noktasında önemli bir yeri olması sebebiyle Tunus’ta yapılan dilbilim çalışmalarına ve orada faaliyet gösteren önemli dilbilimcilerin görüşlerine yer verilecektir. Böylece makalenin asıl amacı olan Tunus’taki modern dil çalışmalarına dair belli bir perspektif sunulmaya çalışılacaktır.