bluuebunny/crossref_metadata_2025 huggingface dataset:
Administration of anti‐CTLA‐4 monoclonal antibody augments protective immunity induced by Schistosoma japonicum glutathione‐S‐transferase
Authors: Tang Chun‐lian , Pan Qun , Dai Wen‐qin , Hu Li‐dong , Zhou Hong‐hua , Wang Li‐xia
Published: May 2019

Aims

The aim of this study was to evaluate the effect of anti‐CTLA‐4 monoclonal antibody (mAb) on 26‐kDa glutathione‐S‐transferase (GST) vaccine–induced immunity against Schistosoma japonicum infection.

Methods and Results

Mice immunized with GST before infection with S japonicum cercariae were injected with anti‐CTLA‐4 mAb. Worm reduction rate of GST was increased from 25.41% in mice with GST immunization to 52.48% in mice with GST plus anti‐CTLA‐4 mAb. The percentages of regulatory T cells (Tregs) were significantly higher following administration of both GST and anti‐CTLA‐4 mAb, or anti‐CTLA‐4 mAb alone. Elevated levels of IFN‐γ, IL‐2, IL‐4 and IL‐5 were observed.

Conclusion

These results demonstrated that CTLA‐4 may inhibit the protective effect of GST vaccine, and anti‐CTLA‐4 mAb may be used as an adjuvant to enhance the immune protection conferred by the GST vaccine by enhancing Th1‐ and Th2‐type immune response.
Managing Perishable Inventory Systems with Multiple Priority Classes
Authors: Abouee‐Mehrizi Hossein , Baron Opher , Berman Oded , Chen David
Published: May 2019

Preferences for different ages of perishable products exist in many applications, including grocery items and blood products. In this paper, we study a multi‐period stochastic perishable inventory system with multiple priority classes that require products of different ages. The firm orders the product with a positive lead time and sells it to multiple demand classes, each only accepting products with remaining lifetime longer than a threshold. In each period, after demand realization, the firm decides how to allocate the on‐hand inventory to different demand classes with different backorder or lost‐sale cost. At the end of each period, the firm can dispose inventory of any age. We formulate this problem as a Markov decision process and characterize the optimal ordering, allocation, and disposal policies. When unfulfilled demand is backlogged, we show that the optimal order quantity is decreasing in the inventory levels and is more sensitive to the inventory level of fresher products, the optimal allocation policy is a sequential rationing policy, and the optimal disposal policy is characterized by n − 1 thresholds. For the lost‐sale case, we show that the optimal allocation and disposal policies have the same structure but the optimal ordering policy may be different. Based on the structure of the optimal policy, we develop an efficient heuristic with a cost that is at most 4% away from the optimal cost in our numerical examples. Using numerical studies, we show that the ordering and allocation policies are close to optimal even if the firm cannot intentionally dispose products. Moreover, ignoring the differences between demand classes and using simple allocation policy (e.g., FIFO) can significantly increase the total cost. We examine how the firm can improve the control of perishable items and show that the benefit of decreasing the lead time is more significant than that of increasing the lifetime of the products or that of decreasing the acceptance threshold of the demand. The analysis is extended to systems with age dependent disposal cost and with stochastic supply.
Invariant discrete flows
Authors: Benson Joseph , Valiquette Francis
Published: May 2019

In this paper, we investigate the evolution of joint invariants under invariant geometric flows using the theory of equivariant moving frames and the induced invariant discrete variational complex. For certain arc length preserving planar curve flows invariant under the special Euclidean group , the special linear group , and the semidirect group , we find that the induced evolution of the discrete curvature satisfies the differential‐difference mKdV, KdV, and Burgers' equations, respectively. These three equations are completely integrable, and we show that a recursion operator can be constructed by precomposing the characteristic operator of the curvature by a certain invariant difference operator. Finally, we derive the constraint for the integrability of the discrete curvature evolution to lift to the evolution of the discrete curve itself.
Initial conditions for the cylindrical Korteweg‐de Vries equation
Authors: Grimshaw Roger
Published: May 2019

In this paper, we find suitable initial conditions for the cylindrical Korteweg‐de Vries equation by first solving exactly the initial‐value problem for localized solutions of the underlying axisymmetric linear long‐wave equation. The far‐field limit of the solution of this linear problem then provides, through matching, an initial condition for the cylindrical Korteweg‐de Vries equation. This initial condition is associated only with the leading wave front of the far‐field limit of the linear solution. The main motivation is to resolve the discrepancy between the exact mass conservation law, and the “mass” conservation law for the cylindrical Korteweg‐de Vries equation. The outcome is that in the linear initial‐value problem all the mass is carried behind the wave front, and then the “mass” in the initial condition for the cylindrical Korteweg‐de Vries equation is zero. Hence, the evolving solution in the cylindrical Korteweg‐de Vries equation has zero “mass.” This situation arises because, unlike the well‐known unidirectional Korteweg‐de Vries equation, the solution of the initial‐value problem for the axisymmetric linear long‐wave problem contains both outgoing and ingoing waves, but in the cylindrical geometry, the latter are reflected at the origin into outgoing waves, and eventually the total outgoing solution is a combination of these and those initially generated.
Cultural group perception enhances sense of agency in a multicultural society
Authors: Li Ming , Li Liman Man Wai , Zhao Ke , Gao Ding‐Guo
Published: May 2019

Group, which involves collective actions for achieving shared goals, can be conceptually understood as an important source of agency and control. The current research investigated whether group identity salience can enhance sense of agency within the individual. Specifically, we examined whether an activated cultural group identity, through presenting different types of cultural photographs in a predictable way, would facilitate people's sense of agency by using an implicit method, namely, intentional binding effect paradigm. Experiment 1a found that an activated cultural group identity enhanced the sense of agency. Next, Experiment 1b replicated the findings by recruiting a different ethnic group in the same society. Experiment 2 explored what may affect the intensity of induced sense of agency and found that perceived representativeness of the presented cultural stimuli was positively correlated with the intensity of induced sense of agency. Finally, Experiment 3 explored whether ethnic minority and majority groups would demonstrate different intensity of agency when their cultural identity was activated. The results showed that the sense of agency induced by the mainstream cultural stimuli was greater than that induced by the foreign cultural photographs. These patterns were not different between the two ethnic groups. Taken together, these findings reflected the dynamic nature of cultural identity construction in a multicultural society.
Glucosylation of the phytoalexin N‐feruloyl tyramine modulates the levels of pathogen‐responsive metabolites in Nicotiana benthamiana
Authors: Sun Guangxin , Strebl Michael , Merz Maximilian , Blamberg Robert , Huang Fong‐Chin , McGraphery Kate , Hoffmann Thomas , Schwab Wilfried
Published: May 2019

Enzyme promiscuity, a common property of many uridine diphosphate sugar‐dependent glycosyltransferases (UGTs) that convert small molecules, significantly hinders the identification of natural substrates and therefore the characterization of the physiological role of enzymes. In this paper we present a simple but effective strategy to identify endogenous substrates of plant UGTs using LC‐MS‐guided targeted glycoside analysis of transgenic plants. We successfully identified natural substrates of two promiscuous Nicotiana benthamiana UGTs (NbUGT73A24 and NbUGT73A25), orthologues of pathogen‐induced tobacco UGT (TOGT) from Nicotiana tabacum, which is involved in the hypersensitive reaction. While in N. tabacum, TOGT glucosylated scopoletin after treatment with salicylate, fungal elicitors and the tobacco mosaic virus, NbUGT73A24 and NbUGT73A25 produced glucosides of phytoalexin N‐feruloyl tyramine, which may strengthen cell walls to prevent the intrusion of pathogens, and flavonols after agroinfiltration of the corresponding genes in N. benthamiana. Enzymatic glucosylation of fractions of a physiological aglycone library confirmed the biological substrates of UGTs. In addition, overexpression of both genes in N. benthamiana produced clear lesions on the leaves and led to a significantly reduced content of pathogen‐induced plant metabolites such as phenylalanine and tryptophan. Our results revealed some additional biological functions of TOGT enzymes and indicated a multifunctional role of UGTs in plant resistance.
Genome analysis of methicillin‐resistant Staphylococcus aureus isolated from pigs: Detection of the clonal lineage ST398 in Cameroon and South Africa
Authors: Founou Luria Leslie , Founou Raspail Carrel , Allam Mushal , Ismail Arshad , Finyom Djoko Cyrille , Essack Sabiha Yusuf
Published: May 2019

Food animals are considered reservoirs of methicillin‐resistant Staphylococcus aureus (MRSA) and are implicated in their zoonotic transmission in the farm‐to‐plate continuum. LA‐MRSA has been reported as a zoonotic agent that has the potential to spread to humans and may cause infections in at‐risk groups. In this study, whole genome sequencing was used to describe the genetic environment (resistance mechanisms, virulence factors and mobile genetic elements) and investigate the genetic lineages of MRSA isolates from pigs in Cameroonian and South African abattoirs. During March–October 2016, 288 nasal and rectal pooled samples from 432 pigs as well as nasal and hand swabs from 82 humans were collected. Genomic DNA was sequenced using an Illumina MiSeq platform. Generated reads were de novo‐assembled using the Qiagen CLC Genomics Workbench and SPAdes. The assembled contigs were annotated, and antibiotic resistance genes, virulence factors, plasmids, SCCmec and phage elements were identified with ResFinder, Virulence Finder, PlasmidFinder, SCCmec Finder and PHAST, respectively. Core genome single nucleotide analysis was undertaken to assess clonal relatedness among isolates. A lower MRSA prevalence was observed in pigs in Cameroon (n = 1/13; 0.07%) compared with South Africa (n = 4/22; 18.18%), and none of the workers were colonized by MRSA. Genome analysis identified various antibiotic resistance genes along with six virulence factors in all isolates. All MRSA isolates belonged to the clonal lineage ST398 (spa‐type t011) and harboured the type Vc SCCmec and several plasmids. Our study shows that the livestock‐associated MRSA clonal lineage ST398 is already present in both Cameroon and South Africa and is probably underestimated in the absence of molecular epidemiological studies. It reveals the serious food safety and public health threat associated with this animal strain and underscores the need for interventions to contain this resistant clone.
Leucine rich repeat kinase 2: a paradigm for pleiotropy
Authors: Lewis Patrick A.
Published: May 2019

The LRRK2 gene, coding for leucine rich repeat kinase 2 (LRRK2), is a key player in the genetics of Parkinson's disease. Despite extensive efforts, LRRK2 has proved remarkably evasive with regard to attempts to understand both the role it plays in disease and its normal physiological function. At least part of why LRRK2 has been so difficult to define is that it appears to be many things to many cellular functions and diseases – a pleiotropic actor at both the genetic and the molecular level. Gaining greater insight into the mechanisms and pathways allowing LRRK2 to act in this manner will have implications for our understanding of the role of genes in the aetiology of complex disease, the molecular underpinnings of signal transduction pathways in the cell, and drug discovery in the genome era.

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Highly selective electrochemical hydrogenation of alkynes: Rapid construction of mechanochromic materials
Authors: Li Bijin , Ge Haibo
Published: May 2019

Electrochemical hydrogenation can convert alkynes to synthetically useful Z-alkenes under mild conditions.
Ultraselective glassy polymer membranes with unprecedented performance for energy-efficient sour gas separation
Authors: Yi Shouliang , Ghanem Bader , Liu Yang , Pinnau Ingo , Koros William J.
Published: May 2019

Purification of massive sour natural gas resources is enabled by transformational glassy polymer membranes described herein.
Identification of two distinct pathways of human myelopoiesis
Authors: Drissen Roy , Thongjuea Supat , Theilgaard-Mönch Kim , Nerlov Claus
Published: May 2019

Distinct myeloid differentiation pathways give rise to either neutrophil/monocyte or basophil/mast cell/eosinophil lineages.
Limited auricular relapsing polychondritis in a child treated successfully with infliximab
Authors: Alqanatish Jubran Theeb , Alfarhan Basma Ali , Qubaiban Sara Mohammed
Published: May 2019

Relapsing polychondritis (RP) is a rare progressive and destructive multisystem disorder characterised by recurrent inflammation of cartilaginous structures. It is a rare disease in paediatrics compared with adults. In children, the diagnosis is either delayed or overlooked due to low incidence. Auricular chondritis has been described in more than half of paediatric cases with RP. However, isolated auricular chondritis has not been reported as the only presentation of pediatric-onset RP. We described a lad who presented with isolated auricular chondritis, which is refractory to conventional treatment, including glucocorticoids and methotrexate as steroid-sparing agent. Remission of his disease’s relapses was sustained with infliximab. Limited auricular involvement as a presenting feature of RP in the absence of systemic association is very rare in children. We describe a case of successful use of infliximab on limited auricular chondritis disease.
Health state utility values in schizophrenia: protocol for a systematic review and meta-analysis
Authors: Aceituno David , Pennington Mark , Iruretagoyena Barbara , Prina Matthew A , McCrone Paul
Published: May 2019

Introduction

Cost-effectiveness analyses that use quality-adjusted life-years (QALYs) allow comparing the value for money of interventions across different health problems. Health state utility values (HSUVs) are crucial to calculate QALYs. These are weights attached to a given health state reflecting preferences in health-related quality of life (HRQoL). In schizophrenia, there is extensive evidence about the consequences of this condition on HRQoL. Besides, several interventions have claimed to be cost-effective in terms of QALYs gained. Despite this evidence, a systematic review of HSUVs has not been conducted. Therefore, we aim to synthesise the evidence about HSUVs in schizophrenia.

Methods and analysis

We will conduct a systematic review of the literature about HSUVs in people with schizophrenia following the Preferred Reporting Items for Systematic review and Meta-Analysis and the International Society for Pharmacoeconomics and Outcomes Research task force recommendations. The submissions records of eight electronic peer-reviewed databases and three health technology assessment (HTA) agencies will be searched. Quantitative synthesis will be carried out in comparable studies, using random-effects meta-analysis. Heterogeneity will be explored using meta-regression if more than 10 studies per covariate are found. A narrative synthesis and methodological quality of included studies will be also reported.

Discussion

This review will provide a synthesis of the HSUVs estimated for different states experienced by people with schizophrenia. This will inform analysts when calculating QALYs, using values in a more transparent and accountable manner. Finally, it will shed light on evidence gaps and limitations about this measure in mental health.

PROSPERO registration number

CRD42019123582.
Performance of the Psoroptes ovis antibody enzyme‐linked immunosorbent assay in the face of low‐level mite infestation
Authors: Hamer Kim , Burgess Stewart , Busin Valentina , Sargison Neil Donald
Published: May 2019

Psoroptes ovis mites, the causative agent of sheep scab, can severely compromise sheep welfare and production. However, in subclinical infections, mite detection is difficult increasing the risk of spread. A recent serodiagnostic test, based on detecting host antibodies to the P ovis allergen, Pso o 2, has made the detection of subclinical infection possible. The use of this test was demonstrated in subclinical situations, through an opportunistic observational study on an extensive hill farm and a lowland flock with recently introduced, quarantined livestock. Twelve animals were tested from each group. Breeding ewes and lambs on the hill farm had seroprevalences of 16 per cent (12.5–17.8 per cent) and 8.3 per cent (4.8–10.1 per cent), respectively. Quarantined store lambs had a seroprevalence of 16.7 per cent (13.2–18.5 per cent); no evidence of P ovis was found in quarantined replacement ewes. By detecting subclinical infection, this serological test could be a powerful tool in sheep scab control, for quarantine procedures, accreditation programmes, and possibly regional or national eradication protocols.
Critical skating intensity on a slide board: physiological and neuromuscular responses and correlation with performance on ice
Authors: Piucco Tatiane , Phillips Julia , Finnie Jordan , Rados Andrew , de Lucas Ricardo Dantas
Published: May 2019

The aim of this study was to assess the physiological and neuromuscular responses at critical skating intensity on a slide board and to investigate the correlations between critical cadence (CC) and skating performances on ice. Thirteen well-trained speed skaters (age,19.8 ± 4.2 years; weight, 69.6 ± 9.06 kg) performed a maximal skating incremental test (IT) on a slide board. CC was determined from 3 to 4 trials to exhaustion lasting from 3.1 ± 0.7 to 13.9 ± 3.1 min, using linear and hyperbolic mathematical fittings. A time to exhaustion test at CC (TTE-CC) was performed. CC values (55.3 ± 5.0 ppm) were significantly higher than cadence at the respiratory compensation point (RCP) (53.5 ± 4.0 ppm). Mean duration of TTE-CC was 22.9 ± 4.8 min. Peak values of oxygen uptake, heart rate (HR), ventilation, respiratory exchange ratio (RER), and ratings of perceived exertion (RPE) during TTE-CC were significantly lower (p < 0.05) than the peak values reached during the IT. Oxygen uptake, HR, ventilation, RER, and RPE significantly increased from 25% to 100% of TTE-CC. Muscle activity (integrated electromyography) significantly increased after 75% of TTE-CC for vastus lateralis and gluteus maximus muscles. Oxygen uptake at CC was better associated to skating performance on 500, 1000, 1500, and 5000 m than peak oxygen uptake at IT and oxygen uptake at RCP. Physiological responses indicate that critical skating intensity on slide board occurred within the heavy exercise domain where oxygen uptake increases but does not reach its maximum. Critical cadence could be used as a better indicator of performance and training prescription for long track speed skating distances.
Processed ground-motion records from induced earthquakes for use in engineering applications
Authors: Assatourians Karen , Atkinson Gail M.
Published: May 2019

We compile and process an electronic database of ground motions recorded on accelerometers and broadband seismographic instruments for induced earthquakes of M ≥ 4 at distances <50 km in central and eastern North America. Most of the data are from Oklahoma, with some records from Alberta. Our focus is on the subset of available records that are of most interest for engineering analyses aimed at evaluation of the potential hazards from induced events, which is a pressing issue in western Canada and other regions experiencing induced seismicity. We considered all records to 50 km for events of M ≥ 4.5. For events of M 4 to 4.5, we select records at close distance (<10 km), having good signal strength (PGA > ∼3%g), to allow high-quality time histories to be obtained. These records have strong signal-to-noise ratio, making them suitable for engineering applications, such as dynamic analysis, after proper scaling. The selected records are windowed, filtered, and instrument-corrected to compile a set of records having acceptable acceleration, velocity, and displacement time histories. The records and their response spectra are provided as an electronic supplement at http://www.seismotoolbox.ca/IS_Strong_Motions/ . We note that the record set is not suitable as a response spectra database for development of ground-motion prediction equations, because for M < 4.5 the record selection is biased to records with higher amplitudes. Rather, the intended use of the records is as seed records, which can be readily scaled in the time domain to approximately represent induced-event target scenarios for engineering applications.
Retraction: The 1/2 correction forms in geometric quantization of the symmetric free rigid body
Authors: Hedrea Ciprian , Negrea Romeo , Zaharie Ioan
Published: May 2019

The Romanian National Committee of Ethics has detected plagiarism in this article. Its publication status is now retracted with immediate effect from IJGMMP.

Publisher's Note:

As of 8th June 2020, the case is under dispute and pending for final court decision.

http://portal.just.ro/30/SitePages/Dosar.aspx?id_dosar=3000000000111746&id_inst=30

https://curteadeapeltimisoara.eu/Detalii_Dosar.aspx?id=9556%2f30%2f2015&idinstanta=59
Logarithmic corrections in the asymptotic expansion for the radiation field along null infinity
Authors: Angelopoulos Yannis , Aretakis Stefanos , Gajic Dejan
Published: May 2019

We obtain the second-order late-time asymptotics for the radiation field of solutions to the wave equation on spherically symmetric and asymptotically flat backgrounds including the Schwarzschild and sub-extremal Reissner–Nordström families of black hole spacetimes. These terms appear as logarithmic corrections to the leading-order asymptotic terms which were rigorously derived in our previous work. Such corrections have been heuristically and numerically derived in the physics literature in the case of a non-vanishing Newman–Penrose constant. In this case, our results provide a rigorous confirmation of the existence of these corrections. On the other hand, the precise logarithmic corrections for spherically symmetric compactly supported initial data (and hence, with a vanishing Newman–Penrose constant) explicitly obtained here appear to be new.
Advancing Drug Development in Gynecologic Malignancies
Authors: Beaver Julia A. , Coleman Robert L. , Arend Rebecca C. , Armstrong Deborah K. , Bala Sanjeeve , Mills Gordon B. , Sood Anil K. , Herzog Thomas J.
Published: May 2019

Gynecologic malignancies continue to be a major cause of morbidity and mortality in the United States despite recent advances in oncologic therapies. To realize the promise of immunotherapy and biomarker-driven approaches to improve clinical outcomes for patients, better communication among stakeholders in the drug development and approval pathways is needed. To this end, the FDA-AACR-SGO Drug Development in Gynecologic Malignancies Workshop brought together clinicians, patient advocates, researchers, industry representatives, and regulators in June 2018, to review the state of the science in gynecologic cancers and explore how scientific advances impact approval processes. Topics of discussion and key takeaways are summarized in this Perspectives in Regulatory Science and Policy article. Single-agent immunotherapies have demonstrated variable and often modest response rates among gynecologic cancers. Combination therapies and other novel approaches, such as cell-based therapies, may show improved efficacy compared with single-agent immunotherapies; however, utilizing innovative clinical trial designs will be necessary to progress further. Companion and complementary diagnostics inform physicians of potential benefits of specific therapeutics for patients; however, they serve different functions that have important regulatory implications, thus trialists should understand the distinctions between diagnostic types. PARP inhibitors hold great promise for treating ovarian cancers, both as monotherapies and in combination with chemotherapeutics, other targeted agents, and immunotherapies. Rare gynecologic cancers often exhibit unique molecular characteristics that can serve as effective targets to which novel therapeutics can be developed. This workshop highlighted the importance of future open discussions on scientific and regulatory challenges in drug development for gynecologic malignancies.
Potential Rediscovery of a Distinct Slow Loris Nycticebus (Mammalia: Strepsirrhini: Lorisidae) from Pulau Tioman
Authors: Welch Ashley Robert
Published: May 2019

Several slow loris (Nycticebus) sightings have occurred on the island of Pulau Tioman, Peninsular Malaysia, from 2011 to 2018. Records discussed here represent the first confirmed sightings and photographic evidence of Nycticebus on Tioman since its discovery in 1915, refuting presumptions that the Tioman slow loris is extinct. Although originally considered a subspecies of the Sunda slow loris (Nycticebus coucang), several morphological characteristics apparent in all observed individuals, including the white interocular stripe, rufous colouration and pale dorsal stripe, are similar to the Philippine slow loris (Nycticebus menagensis). Further, the broad snout and ears may be unique to this population and suggest that the population may be distinct. I, therefore, recommend that future studies consider the taxonomic status of remote and isolated Nycticebus populations given the possibility that they may represent distinct and unrecognised taxa.
Mimickers in Spine: Migrated Cages Causing Radiculopathy
Authors: Nanda Saurav Narayan , Jain Mantu , Behera Sudarsan , Gaikwad Manisha
Published: May 2019

The procedure of interbody fusion has become an established treatment for many spine disorders. This arthrodesis can be achieved by hardware (fusion cage) through many approaches. Initially, posterior lumbar interbody fusion was popularized but had some serious neurological complications related to insertion as well as the migration of the cage. Gradually, transforaminal lumbar interbody fusion (TLIF) was introduced, which proved safer as it involves minimal cord handling, and also migration, if any, remains asymptomatic. We had two patients who were operated for interbody fusion using TLIF technique with subsequent posterior migration of the banana-shaped fusion cage 4–6 month after the index surgery. Both patients presented with radiculopathy mimicking a prolapsed intervertebral disc. These were evaluated and operated with the removal of the migrated cages and revision with bigger-size cages with adequate bone grafting. At the 1-year follow-up, both had remission of symptoms, and radiographs showed no subsequent migration. TLIF procedure is an established procedure to achieve arthrodesis in varying spine disorders with promising result. However, there are only a few reports describing cage migration after the procedure and these have been asymptomatic. Revision surgery is contemplated in the setting of neurological compression or instability. A bigger fusion cage in a compressive mode with adequate bone grafting is used to achieve arthrodesis. The principles of interbody fusion must be followed, and utmost precautions must be taken to prevent this unfortunate complication.
Propofol Sedation in the Endoscopy Room versus Operation Room during Endoscopic Submucosal Dissection for Gastric Tumors: A Propensity Score-Matching Analysis
Authors: Takeuchi Yuki , Yamaguchi Daisuke , Yamaguchi Naoko , Ikeda Kei , Yoshioka Wataru , Fukuda Hiroko , Morisaki Tomohito , Ario Keisuke , Tsunada Seiji , Katsuki Ryo , Tominaga Naoyuki , Yamasaki Satoko , Eguchi Yuichiro , Ogata Shinichi , Fujimoto Kazuma
Published: May 2019

Background/Aims: The present study was performed to compare the safety of sedation with propofol during endoscopic submucosal dissection (ESD) for gastric tumors under sedation in the endoscopy room by an endoscopist versus sedation in the operation room by an anesthesiologist. Methods: In total, 638 patients with gastric tumors who underwent ESD from January 2011 to August 2017 at Ureshino Medical Center and Saga Medical Center Koseikan were retrospectively reviewed. The patients were divided into 2 groups: those who underwent ESD in the endoscopy room (Group E, n = 532) and those who underwent ESD in the operation room (Group O, n = 106). Propensity score matching was applied for evaluation. The treatment outcome of ESD and the adverse events of sedation during ESD (desaturation, hypotension, bradycardia, and arrhythmia) were compared between the 2 groups to consider the safety of ESD. Results: The propensity score-matching analysis created 82 matched pairs. Adjusted comparisons between Groups E and O showed similar treatment outcomes of ESD for gastric tumors. There were no significant differences in the treatment outcomes, anesthesia time, and mean propofol dose between the 2 groups. With respect to adverse events, desaturation occurred more often in Group E than Group O (18.3 vs. 3.7%, respectively; p = 0.005). There were no significant differences in other adverse events (hypotension, bradycardia, and arrhythmia) between the 2 groups. Conclusion: Sedation with propofol in the operation room might be required to ensure safer application of ESD for gastric tumors. However, a decrease in the desaturation rate was the only disadvantage of sedation in the endoscopy room.
INVENTÁRIO DE BENS CULTURAIS: CONHECER E COMPREENDER
Authors: Rodrigues Marly
Published: May 2019

A partir de inventários realizados na década de 1970 pelo Conselho de Defesa do Patrimônio Histórico, Arqueológico, Artístico e Turístico (Condephaat) busca-se identificar algumas razões e a dinâmica que vêm impedindo a adoção de práticas sistemáticas de identificação de bens culturais e os efeitos disso na sociedade.
Review of the Nearctic species of Leiophron and Peristenus (Hymenoptera: Braconidae: Euphorinae) parasitizing Lygus (Hemiptera: Miridae: Mirini)
Authors: GOULET HENRI , MASON PETER G.
Published: May 2019

Plant bugs belonging to the genus Lygus Hahn (Hemiptera: Miridae) are important pests of a wide variety of North American crops. Efforts to use biological control as one strategy in an integrated pest management approach have been impeded by a poor understanding of the endoparasitoids, particularly species of the genera Leiophron Nees and Peristenus Foerster (Hymenoptera: Braconidae) many of which parasitize the nymphal stages of Lygus, among other Miridae. The taxonomy of Leiophron and Peristenus species associated with agricultural habitats is reviewed based on reared material contributed by numerous researchers. Sixteen species of the two genera were found parasitizing Lygus nymphs, including the following eight species described as new, Leiophron australis Goulet, L. simoni Goulet, Peristenus braunae Goulet, P. broadbenti Goulet, P. carcamoi Goulet, P. dayi Goulet, P. gillespiei Goulet and P. otaniae Goulet. The species are differentiated in a key, described and illustrated. Two names are newly placed in synonymy, L. trigonotylidis Loan, 1974 under Leiophron lygivorus (Loan 1970) and Brachistes nocturnus Viereck, 1905 under P. mellipes (Cresson 1872). Euphorus mellipes Cresson is removed from synonymy with P. pallipes (Curtis). Most of the endoparasitoid species are known to be associated only with Lygus spp. and appear to be distinct in their distribution and their biology. Analysis of the endoparasitoid complex in southern Quebec shows that of the six species that occur in alfalfa and hay fields, four species use Lygus lineolaris (Palisot) as the main host. The introduced Peristenus digoneutis Loan has recently established in southern Quebec and although its numbers have increased substantially it has not yet had an evident impact on reducing L. lineolaris population levels.
A review of harvestmen (Arachnida: Opiliones) in Slovenia*
Authors: NOVAK TONE , DELAKORDA SAŠA LIPOVŠEK , NOVAK LJUBA SLANA
Published: May 2019

The authors present a short historical faunistic, zoogeographical and ecological review of research on harvestmen (Opiliones) of the territory of presentday Slovenia, and discuss some actual ecological and nature conservational questions. Till recent, 64 species plus two subspecies of Opiliones inhabiting Slovenia are recorded, most of these are Alpine, European, Central- and Western European elements. Taxonomically, there are some open questions, especially in the genus Trogulus. A small number of further species can be expected in Slovenia, raising the potential final number to 69-71. Some harvestmen are locally and regionally endangered, especially by anthropogenous habitat and ecosystem changes.
Spatiator martensi n. sp., a second species of the extinct spider family Spatiatoridae in Eocene Baltic amber (Araneae)
Authors: WUNDERLICH JÖRG
Published: May 2019

Spatiator martensi n. sp. (Araneae: Spatiatoridae) is described from the Early Tertiary Baltic amber forest. It is the second known species of this extinct family of spiders. Ants as syninclusions point to a possible ant mimicry or myrmecophagy.
Characterization of a secondary contact zone of the Great Tit Parus major and the Japanese Tit P. minor (Aves: Passeriformes) in Far Eastern Siberia with DNA markers
Authors: KVIST LAURA , RYTKÖNEN SEPPO
Published: May 2019

The Great Tit Parus major and the Japanese Tit P. minor meet and hybridize in a secondary contact zone in Far Eastern Amur River Valley. The genetic characteristics of this hybrid zone were studied by nuclear microsatellites and mitochondrial DNA sequences. Patterns of introgression of nuclear markers, mitochondrial markers and phenotypic characters were found to be different. The possible reasons, such as stronger selection against heterogametic females according to Haldane’s rule, lowered hybrid fitness, assortative mating and factors enforcing introgression, like density-dependent pair-formation, are discussed.
Song dialects as diagnostic characters — acoustic differentiation of the Canary Island Goldcrest subspecies Regulus regulus teneriffae Seebohm 1883 and R. r. ellenthalerae Päckert et al. 2006 (Aves: Passeriformes: Regulidae)
Authors: PÄCKERT MARTIN
Published: May 2019

Acoustic differentiation among Goldcrests (Regulus regulus) from the Canary Islands was investigated by sonagraphic analysis with respect to the recently discovered genetic subdivision of the Canarian populations into a clade from Tenerife and La Gomera (nominate ssp. teneriffae) and a second clade from La Palma and El Hierro (recently described as ssp. ellenthalerae). One common dialect, song type A, was found on all four islands inhabited by Goldcrests and is also present on São Miguel, Azores (ssp. azoricus). This one is composed of a rapid trill introduction followed by an ascending part and a terminal flourish. Further Canarian song types are variations of this dialect, differing in trill elements and composition of the second ascending phrase. A remarkably different dialect was exclusively found in the Anaga Mountains on Tenerife. The rhythmic song pattern of alternating high- and lower-pitched elements shows strong resemblance to the song of European nominate regulus and to other island dialects from the Azores. Local variations of song type A were found on El Hierro and La Palma. Three acoustic clusters can be distinguished by discriminant analysis, one comprising all songs of ssp. ellenthalerae from La Palma and El Hierro and two further teneriffae clusters encompassing songs from La Gomera on the one hand and those from Tenerife on the other. The findings are discussed with respect to the potential evolutionary causes of the different song repertoires on the Canaries, the Azores and the European continent and to the use of acoustic markers for taxonomic diagnosis.
A new species of Macrophiothrix (Ophiuroidea: Ophiotrichidae) common in northern Australia
Authors: HOGGETT ANNE K.
Published: May 2019

A new brittlestar species Macrophiothrix caenosa is described from Darwin, Northern Territory, Australia. It is common throughout tropical Australia and is also recorded from Japan and Singapore. It is distinguished from congeners by the combination of trapeziform dorsal arm plates, short multifid disc stumps, radial shields with stumps or rugose granules, dental plate shape, arrangement of dental papillae and distribution of ventral disc armament.
Two new genera of Laophontidae (Copepoda: Harpacticoida) without sexual dimorphism in the endopods of the swimming legs
Authors: GHEERARDYN HENDRIK , FIERS FRANK , VINCX MAGDA , DE TROCH MARLEEN
Published: May 2019

Two new monospecific genera of the harpacticoid family Laophontidae T. Scott, 1905 are described here. Apistophonte wasiniensis gen. et sp. n. was found along the Kenyan coast and Propephonte duangitensis gen. et sp. n. along the northern coast of Papua New Guinea. They differ from most other laophontid genera in the absence of sexual dimorphism in the endopods of the swimming legs. At first sight, both new species resemble each other very closely in habitus, integumental ornamentation, chaetotaxy of the swimming legs and absence of sexual dimorphism in the endopods. However, the detailed characteristics of A1, maxilla and male P5 show that the species are not congeneric. The structure of the first antennular segment of Propephonte gen. n. suggests a close relationship with Peltidiphonte Gheerardyn and Fiers, 2006. The exact affinities of Apistophonte gen. n. however remain difficult to assess.
Comparative larval morphology in Madagascan frogs of the genus Guibemantis (Amphibia: Mantellidae)
Authors: VEJARANO SILVIA , THOMAS MEIKE , VENCES MIGUEL
Published: May 2019

We describe the tadpole morphology for four species of frogs classified in the endemic Madagascan genus Guibemantis, based on larval specimens identified by DNA barcoding. The tadpoles of Guibemantis kathrinae and G. tornieri are reported for the first time. The tadpole of G. kathrinae has a heterogeneous coloration, emarginated oral disc bordered with papillae and one row of submarginal papillae. Labial tooth row formula is 6(2–6)/3(1). Number of labial teeth per millimetre is variable in each row, ranging from 36 to 64. The tadpole of G. tornieri is very similar to that of G. timidus (previously considered conspecific with G. tornieri) except for the patched coloration of G. tornieri (vs. rather uniform in G. timidus). The tadpole of G. depressiceps is characterized by having a higher number of teeth per millimetre in all tooth rows than the other species of the group. The tadpole of Guibemantis liber differs from the other species by having a lower number of upper labial tooth rows (two, three or four vs. five or more). No morphological differences were found between larvae of G. liber from two separate localities, Ranomafana and Andasibe. In general, the Guibemantis larvae examined (except G. liber) are morphologically similar to each other but several of the characters examined were highly variable within populations and species, highlighting the usefulness of molecular tools for their identification.
A new species of Protandrena Cockerell from Brazil (Hymenoptera, Apidae, Andreninae)*
Authors: RAMOS KELLI S. , MELO GABRIEL A.R.
Published: May 2019

Protandrena avulsa new species, from Espirito Santo and Minas Gerais (southeastern Brazil) is described and illustrated. This species is unique within Protandrena for its well-developed pronotal lamella, similar to what is found in Pseudopanurgus and Parapsaenythia, and by its protuberant interantennal area. This is the first record of this bee genus in Brazil.
Ypsolopha rhinolophi sp. nov. (Lepidoptera: Ypsolophidae), a new species from Portugal and France unveiled by bats
Authors: CORLEY MARTIN , FERREIRA SÓNIA , MATA VANESSA A.
Published: May 2019

A new species Ypsolopha rhinolophi Corley is described from northern Portugal and south-east France. It resembles Y. alpella (Denis & Schiffermüller, 1775) and Y. lucella (Fabricius, 1775) but shows clear differences from both species in DNA barcode and in male and female genitalia. Male genitalia of Y. lucella are illustrated for the first time. The new species has been collected at light, reared from larvae on Quercus pyrenaica Willd. and recognised from DNA barcode fragments obtained from droppings of horseshoe bats.
Two new species of Ecpatia Turner, 1902, and the first records of Ecpatia sciachroa Hampson, 1926 and Ecpatia obscura Holloway, 2009 from Thailand (Lepidoptera: Noctuidae, Noctuinae)
Authors: PELLINEN MARKKU J. , MUTANEN MARKO
Published: May 2019

Two new noctuid species, Ecpatia grisescens sp. n., E. spiculivalva sp. n. are described from Thailand based on a combination of morphological characters and DNA barcodes. Morphological structures and genetic distances are compared to those of related species. Ecpatia sciachroa Hampson, 1926 and Ecpatia obscura Holloway, 2009 are reporded from Thailand for the first time, and a checklist of 17 valid species of Ecpatia is provided.
A new species of Limaytilla Casal, 1964 (Hymenoptera: Mutillidae) from Argentina, a key for the known species, and new record data for the Argentinian species
Authors: TORRÉNS JAVIER , FIDALGO PATRICIO
Published: May 2019

A new species of Limaytilla from Argentina is described and illustrated based on males, L. diaguita Torréns & Fidalgo sp. nov.. Diagnoses for both sexes of the genus and an illustrated key for the Argentinian species are provided as well as new record data for L. pampa Casal and L. pehuenche Casal. Habitus photographs of all Argentinian species and L. orlandoi Cambra, Quintero & Pagliano from Chile, are also provided.
Description of the first instar larva of Lytta caraganae (Pallas, 1798) (Coleoptera: Meloidae, Lyttini)
Authors: LI XIU-MIN , REN GUO-DONG , PAN ZHAO
Published: May 2019

Lytta caraganae (Pallas, 1798) is widely distributed in northeast Asia. Its first instar larva hatched from eggs is described and illustrated using scanning electron microscopy (SEM). An update key to the all Lytta species based on first instar larvae is presented.
Contrasting genetic, acoustic, and morphological differentiation in two closely related gladiator frogs (Hylidae: Boana) across a common Neotropical landscape
Authors: ESCALONA S. MOISÉS D. , JUNCÁ FLORA ACUÑA , GIARETTA ARIOVALDO A. , CRAWFORD ANDREW J. , MARCA ENRIQUE LA
Published: May 2019

Mountain chains and rivers are often found to represent barriers promoting vicariant differentiation in terrestrial vertebrates. Previous studies have supported the idea that the Cordillera de Mérida (CM), the easternmost branch of the Northern Andes, represents a geographic barrier for vertebrates, including frogs. Previous studies have also suggested that the Orinoco River (OR), the biggest river in Venezuela, also represents a geographic barrier for terrestrial vertebrates. Boana pugnax and B. xerophylla are two Neotropical hylids, members of the B. faber species group, that are distributed on either side of the CM, and whose ranges extend up to 605 and 2450 m in elevation, respectively. In addition, B. xerophylla occurs on either side of the OR. Herein, we assess the genetic, acoustic, and morphological differentiation within B. pugnax and within B. xerophylla across the CM and within B. xerophylla across the OR, and test if genetic differentiation is correlated with geographic distance. We also evaluated the acoustic differentiation between the recently recognized B. xerophylla and its sister species, B. crepitans, and found marked differences between advertisement calls, corroborating their status as distinct species. Genetic and morphometric analyses of populations from opposite sides of the CM revealed differentiation in B. pugnax but not in B. xerophylla. Within the latter species, we found molecular, acoustic, and morphometric differentiation among samples of B. xerophylla from western Venezuela versus the Guiana Shield. Genetic variation within B. pugnax and within B. xerophylla was not explained by geographic distance. Thus, our data show conspecific population structure across the CM in B. pugnax, plus the possible existence of two species within what today is considered B. xerophylla, yet the CM apparently is not involved in this divergence. These results suggest that even for closely related species with shared ecology and distribution, genetic and phenotypic differentiation respond differently to common ecological or historical factors.
Morphology and molecular phylogeny of four Frontonia species from Turkey (Protista, Ciliophora)
Authors: KIZILDAG SIBEL , YILDIZ ISMAIL
Published: May 2019

In this study, Frontonia leucas, Frontonia acuminata, Frontonia angusta, and Frontonia anatolica species isolated from aquatic environments of Van in Turkey were investigated in detail using morphological, morphometrical, and molecular methods. Although there were minor differences, the Frontonia populations were morphologically similar to the other previously reported populations of the 4 species. Frontonia leucas differed from the other populations by the following combination of characters: about 200 somatic and only 3 vestibular kineties, and a single micronucleus. The Turkish population of Frontonia acuminata had just 4 vestibular kineties and the large micronucleus was always located to the anterior of the carrot-shaped macronucleus. The ratio of the oral apparey size to the cell size of Frontonia angusta in this study was about 18%, with 3 vestibular kineties, and 1 excretory pore. Phylogenetic trees based on small-subunit rRNA gene sequences were constructed using Bayesian inference and maximum-likelihood. Frontonia anatolica was more closely related to Apofrontonia dohrni and Paramecium spp. than to its congeners, while F. acuminata, like F. terricola, was also more closely related to the family Stokesiidae. The results indicated that Frontonia is a non-monophyletic genus consisting of 3 groups. We presented the systematic relationships of the genera and families of Peniculida with new data of genus Frontonia herein.
An Evaluation of Model Output Statistics for Subseasonal Streamflow Forecasting in European Catchments
Authors: Schick Simon , Rössler Ole , Weingartner Rolf
Published: May 2019

Subseasonal and seasonal forecasts of the atmosphere, oceans, sea ice, or land surfaces often rely on Earth system model (ESM) simulations. While the most recent generation of ESMs simulates runoff per land surface grid cell operationally, it does not typically simulate river streamflow directly. Here, we apply the model output statistics (MOS) method to the hindcast archive of the European Centre for Medium-Range Weather Forecasts (ECMWF). Linear models are tested that regress observed river streamflow on surface runoff, subsurface runoff, total runoff, precipitation, and surface air temperature simulated by ECMWF’s forecast systems S4 and SEAS5. In addition, the pool of candidate predictors contains observed precipitation and surface air temperature preceding the date of prediction. The experiment is conducted for 16 European catchments in the period 1981–2006 and focuses on monthly average streamflow at lead times of 0 and 20 days. The results show that skill against the streamflow climatology is frequently absent and varies considerably between predictor combinations, catchments, and seasons. Using streamflow persistence as a benchmark model further deteriorates skill. This is most pronounced for a catchment that features lakes, which extend to about 14% of the catchment area. On average, however, the predictor combinations using the ESM runoff simulations tend to perform best.