bluuebunny/crossref_metadata_2025 huggingface dataset:
Efficacy of transumbilical laparoendoscopic single-site surgery versus multi-port laparoscopic surgery for endometrial cancer: a retrospective comparison study
Authors: You Xiaolin , Wang Yanyun , Zheng Ying , Yang Fan , Wang Qiao , Min Ling , Wang Kana , Wang Na
Published: August 2023

Background

Although single-port laparoscopy surgery has been evaluated for several years, it has not been widely adopted by gynecologic oncologists. The objective was to compare the perioperative outcomes and survival of endometrial cancer (EC) patients undergoing transumbilical laparoendoscopic single-site surgery (TU-LESS) with multi-port laparoscopic surgery (MLS).

Materials and methods

This is a retrospective comparative monocentric study including patients treated between December 2017 and October 2021. The perioperative outcomes and survival of EC patients who had surgery via TU-LESS or MLS were compared, by propensity matching.

Results

A total of 156 patients were included (TU-LESS vs. MLS: 78 vs. 78). The conversion rate of TU-LESS and MLS was 5.13% and 2.56%, respectively (P=0.681). The operation time was comparable between the two groups [207.5min (180-251) vs. 197.5min (168.8-225), P=0.095]. There was no significant difference between the two groups in exhaustion time, perioperative complications, or postoperative complications. While, the TU-LESS group had a shorter out-of-bed activity time [36 hours (24-48) vs. 48 hours (48-72), P<0.001] and a lower visual analog pain scale 36 hours after surgery [1 (1-2) vs. 2 (1-2), P<0.001] than the MLS group. The length of hospital stay was similar in the two groups [5(4-6) vs. 5(4-5), P=0.599]. Following surgery, 38.5% of the TU-LESS patients and 41% of the MLS patients got adjuvant therapy (P=0.744). The median follow-up time for TU-LESS and MLS cohorts was 45 months (range: 20-66) and 43 months (range: 18-66), respectively. One TU-LESS patient and one MLS patient died following recurrence. The 4-year overall survival was similar in both groups (98.3% vs. 98.5%, P=0.875).

Conclusion

TU-LESS is a feasible and safe option with comparable perioperative outcomes and survival of MLS in endometrial cancer. With the growing acceptance of sentinel lymph node biopsy, TU-LESS of endometrial cancer may be a viable option for patients and surgeons.
Clinical, radiological and pathological features of temporomesial tumors in the adult. A single center experience from 15 years
Authors: Meyer Hanno S. , Wiestler Benedikt , Hönikl Lisa S. , Delbridge Claire , Ketterer Carl , Gempt Jens , Meyer Bernhard
Published: August 2023

Introduction

The mesial temporal lobe plays a distinct role in epileptogenesis, and tumors in this part of the brain potentially have specific clinical and radiological features. Differentiating high-grade from lower-grade tumors or non-neoplastic lesions can be challenging, preventing the decision for early resection that can be critical in high-grade tumors.

Methods

A brain tumor database was analyzed retrospectively to identify patients with temporomesial tumors. We determined clinical features (age, sex, symptoms leading to clinical presentation) as well as neuroradiological (tumor location and the presence of contrast enhancement on initial magnetic resonance imaging (MRI)) and neuropathological findings.

Results

We identified 324 temporal tumors. 39 involved the mesial temporal lobe. 77% of temporomesial tumors occured in males, and 77% presented with seizures, regardless of tumor type or grade. In patients 50 years or older, 90% were male and 80% had glioblastoma (GBM); there was no GBM in patients younger than 50 years. 50% of GBMs lacked contrast enhancement. Male sex was significantly associated with GBM. In both contrast-enhancing and non-enhancing tumors, age of 50 years or older was also significantly associated with GBM.

Conclusion

In middle-aged and older patients with a mesial temporal lobe tumor, GBM is the most likely diagnosis even when there is no MRI contrast enhancement. Prolonged diagnostic workup or surveillance strategies should be avoided and early resection may be justified in these patients.
Combatting the rising costs of cancer drugs; interventions from a university hospital’s perspective
Authors: Dane Aniek , van Leeuwen Roelof , Hoedemakers Maaike , van der Kuy Hugo , Sleijfer Stefan
Published: August 2023

Rapid increase in cost continues to have negative impact on patients’ accessibility to life-changing anticancer medications. Moreover, the rising cost does not equate to similar increase in medication effectiveness. We recognise our responsibility as a university hospital to tackle this imbalance and strive to provide high quality, sustainable, affordable and accessible care. An active approach in cost containment of expensive and innovative cancer drugs was adopted in our organisation to safeguard accessibility and improve quality of life for patients. In this article, we described four inverventions: 1) identify right patient and minimise overtreatment, 2) in-house medicine production for selected indications, 3) minimise medicine spillages and 4) effective procurement strategies. We call on other hospitals to take action and, favourably, to collaborate on a European level. Together, we will safeguard the current and future care of our patients.
Supporting neurodivergent talent: ADHD, autism, and dyslexia in physics and space sciences
Authors: Turner Niescja E. , Smith Heather Haynes
Published: August 2023

Diversity, equity, inclusion, and belonging efforts must include disability and neurodivergence. While there is a long history of famous scientists being identified or speculatively indicated to be neurodivergent, identification on an individual basis has been limited until fairly recently. Definitions have changed and broadened, and people are being identified or are identifying themselves as neurodivergent and are learning about their paths and their brains in a way that was unavailable to people two decades ago. In the contemporary physics or space science classroom or workplace, we have both a responsibility to include and support our neurodivergent learners and scientists, as well as an opportunity to use insights from the neurodiversity movement to better support our teams and students. Herein we explain the language used to describe neurodivergent traits and offer strategies and ideas to support our neurodivergent community members. These strategies include ideas for supporting executive function as well as tips in the areas of physical comfort and sensory considerations.
Genome-wide QTL mapping for stripe rust resistance in spring wheat line PI 660122 using the Wheat 15K SNP array
Authors: Yan Qiong , Jia Guoyun , Tan Wenjing , Tian Ran , Zheng Xiaochen , Feng Junming , Luo Xiaoqin , Si Binfan , Li Xin , Huang Kebing , Wang Meinan , Chen Xianming , Ren Yong , Yang Suizhuang , Zhou Xinli
Published: August 2023

Introduction

Stripe rust is a global disease of wheat. Identification of new resistance genes is key to developing and growing resistant varieties for control of the disease. Wheat line PI 660122 has exhibited a high level of stripe rust resistance for over a decade. However, the genetics of stripe rust resistance in this line has not been studied. A set of 239 recombinant inbred lines (RILs) was developed from a cross between PI 660122 and an elite Chinese cultivar Zhengmai 9023.

Methods

The RIL population was phenotyped for stripe rust response in three field environments and genotyped with the Wheat 15K single-nucleotide polymorphism (SNP) array.

Results

A total of nine quantitative trait loci (QTLs) for stripe rust resistance were mapped to chromosomes 1B (one QTL), 2B (one QTL), 4B (two QTLs), 4D (two QTLs), 6A (one QTL), 6D (one QTL), and 7D (one QTL), of which seven QTLs were stable and designated as QYrPI660122.swust-4BS, QYrPI660122.swust-4BL, QYrPI660122.swust-4DS, QYrPI660122.swust-4DL, QYrZM9023.swust-6AS, QYrZM9023.swust-6DS, and QYrPI660122.swust-7DS. QYrPI660122.swust-4DS was a major all-stage resistance QTL explaining the highest percentage (10.67%–20.97%) of the total phenotypic variation and was mapped to a 12.15-cM interval flanked by SNP markers AX-110046962 and AX-111093894 on chromosome 4DS.

Discussion

The QTL and their linked SNP markers in this study can be used in wheat breeding to improve resistance to stripe rust. In addition, 26 lines were selected based on stripe rust resistance and agronomic traits in the field for further selection and release of new cultivars.
The perception of affective touch in women affected by obesity
Authors: Tagini Sofia , Scacchi Massimo , Mauro Alessandro , Scarpina Federica
Published: August 2023

Introduction

Pleasant and comforting bodily contacts characterized intimate and affective interactions. Affective touch informs us about others’ emotions and intentions, sustains intimacy and closeness, protecting from loneliness and psychological distress. Previous evidence points to an altered experience of affective touch in clinical populations reporting interpersonal difficulties. However, there is no investigation of affective touch in obesity, which is often associated with negative affective-relational experiences since childhood.

Methods

This study aimed to provide the first evidence about the experience of affective touch in obesity by comparing 14 women with obesity with 14 women with healthy weight. Participants rated the pleasantness of both imagined and actual tactile stimuli, which consisted of (i) soft-brush strokes, (ii) touches of the experimenter’s hand, and (iii) of a plastic stick (as control, non-affective, stimulation). Participants should report the pleasantness of each kind of touch. Moreover, we explored lifespan experiences of affective touch and interpersonal pleasure in social contexts through self-report questionnaires.

Results

No differences emerged for the pleasantness of affective touch (in both the real and imagery task) between the two groups. However, participants with obesity reported less frequent and less satisfying early experiences of affective touch when compared with the controls.

Discussion

Our results spoke in favor of a preserved experience of affective touch when experimentally probed in obesity, despite a limited early exposure to bodily affective contacts. We interpreted our results in the light of the social reconnection hypothesis. Nevertheless, we provided crucial methodological considerations for future research, considering that both the experimenter’s and the brush touch may not resemble adequately real-life experiences, in which affective touch involves intimate people.
Assessing the benefits of the “Intergalactic World” social emotional learning program for 8–12-year-old children in Portugal: perspectives from teachers and caregivers
Authors: Antunes Rita , Alexandre Joana , Guedes Maryse , Filipe Marisa G. , Veríssimo Manuela
Published: August 2023

Introduction

“Intergalactic World” is a new social–emotional program designed to reduce psychopathological symptoms and improve social and emotional skills in children aged 8–12. This study aims to evaluate the program’s benefits from teachers’ and caregivers’ perspectives, focusing on internalizing and externalizing behaviors.

Methods

The findings were obtained through self-reported measures using a pretest-posttest design with a follow-up period, but with no control group. One hundred fifty-four children (M age = 9.66, SD = 0.78) participated in this intervention study. Eleven teachers completed the Teacher’s Report Form (TRF) for these children, and 133 caregivers completed the Child Behavior Checklist (CBCL). Participants without caregivers’ reports were excluded from the analysis. Data were collected at three-time points: before the intervention (T1), immediately after (T2), and 6 months after the implementation of the program (T3).

Results

Results (n = 133) showed an effect of time on the Internalization scores (at T3 for teachers and T2 and T3 for caregivers) with no gender effect and a decrease in the perception of externalizing behaviors with a gender effect: Boys were perceived as exhibiting more externalizing behaviors than girls. However, these behaviors significantly decrease at T3 for teachers and at T2 and T3 for caregivers.

Discussion

Despite its limitations, this study highlights the benefits of employing social–emotional programs to help reduce children’s internalizing and externalizing behaviors. A multi-informant approach enables a comprehensive analysis and provides insights into the child’s significant contexts and interactions with adults.
Antigenic and molecular evidence of Brucella sp.-associated epididymo-orchitis in frugivorous (Artibeus lituratus) and nectarivorous (Glossophaga soricina) bats in Brazil
Authors: Silva Laice A. , Souza Monique F. S. , Torquetti Camila G. , Freitas Daniele C. O. , Moreira Larissa G. A. , Carvalho Thaynara P. , Santana Clarissa H. , Thompson Julia R. , Rosa Daniela C. O. , Jesus Tatiana R. , Paixão Tatiane A. , Santos Renato L.
Published: August 2023

This study included 47 free-ranging bats from the State of Minas Gerais, Brazil. Six bats (12.8%) had genital inflammatory lesions, and two of them (one Artibeus lituratus and one Glossophaga soricina, a frugivorous and a nectarivorous, respectively) were diagnosed with Brucella sp. infection through PCR, and antigens in intralesional macrophages were detected using immunohistochemistry.
Robust Controller Design for a Generic Helicopter Model: An AI-Aided Application for Terrain Avoidance
Authors: Baspinar Baris
Published: August 2023

This paper focuses on robust controller design for a generic helicopter model and terrain avoidance problem via artificial intelligence (AI). The helicopter model is presented as a hybrid system that covers hover and forward dynamics. By defining a set of easily accessible parameters, it can be used to simulate the motion of different helicopter types. A robust control structure based on reinforcement learning is proposed to ensure the system is robust against model parameter uncertainties. The developed generic model can be utilized in many helicopter applications that have been attempted to be solved with sampling-based algorithms or reinforcement learning approaches that take the dynamical constraints into consideration. This study also focuses on the helicopter terrain avoidance problem to illustrate how the model can be useful in these types of applications and provide an artificial intelligence-aided solution to terrain avoidance.
On the Size of the Safety Area around the Launch Trajectory of a Rocket
Authors: Campos Luiz M. B. C. , Silva Manuel J. S.
Published: August 2023

The safety zone around the flight path of a rocket is determined by the fall of debris in the case of an accidental explosion or commanded termination. The trajectory of a tumbling body in a vertical plane is determined by specifying the velocity, flight path angle and angle of attack as functions of time. This involves the lift, drag and pitching moment coefficients as functions of the angle of attack over a full circle—0 to 360 degrees—to account for the tumbling motion. The problem is reduced to a third-order non-linear differential equation for the angle of attack by using the approximation of free fall coordinates. The analytical and numerical solutions show that two types of tumbling fall are possible, one with rotation and the other with oscillation. The tumbling trajectories are plotted and discussed for a variety of initial conditions, mass and aerodynamic properties of the tumbling body.
Accumulation of Different Metals in Tomato (Lycopersicon esculentum L.) Fruits Irrigated with Wastewater
Authors: Tabassam Qaisra , Ahmad Muhammad , Alvi Ambreen , Awais Muhammad , Kaushik Prashant , El-Sheikh Mohamed
Published: August 2023

The present study assessed the accumulation and distribution of metals in tomato (Lycopersicon esculentum L.) fruits grown with wastewater. The concentrations of nine metals (Co, Cd, Mn, Cu, Ni, Fe, Zn, and Pb) were analyzed in wastewater collected from the study site. Four metals with substantially higher concentrations in wastewater, namely Fe, Zn, Mn, and Pb, were selected for further analysis in soil, plant organs, and parts of tomato fruits. In addition, the concentrations of essential nutrients (Na, K, Ca, P, and N) in all samples were also analyzed. Concentrations of Zn (0.77 mg L−1) and Pb (0.44 mg L−1) were found to be the maximum, and Mn concentration was the minimum (0.16 mg L−1) in wastewater samples. However, in soil samples, the concentrations of Fe (35.88 mg kg−1) and Pb (29.62 mg kg−1) were the highest, which ultimately led to their higher accumulation in plant tissues. When metal accumulation in the whole plant and tomato fruit was compared with the WHO permissible limits, the accumulated concentrations of Zn (16.35, 12.98, and 23.85 mg kg−1 d.wt. in peri-, endo-, and mesocarp, respectively), Mn (7.08, 7.75, and 4.6 mg kg−1 d.wt. in peri-, endo-, and mesocarp, respectively), and Pb (30.05, 29.42, and 34.95 mg kg−1 d.wt. in peri-, endo-, and mesocarp, respectively) exceeded the safe limits except for Fe (13.6, 32.3, and 63.43 mg kg−1 d.wt. in peri-, endo-, and mesocarp, respectively). Thus, the irrigation of tomato fruits with wastewater can cause health risks to humans under prolonged consumption, and the regular monitoring of metals is necessary to reduce the health risks from human consumption.
Boundary Controlling Synchronization and Passivity Analysis for Multi-Variable Discrete Stochastic Inertial Neural Networks
Authors: Yang Yongyan , Zhang Tianwei , Li Zhouhong
Published: August 2023

The current paper considers discrete stochastic inertial neural networks (SINNs) with reaction diffusions. Firstly, we give the difference form of SINNs with reaction diffusions. Secondly, stochastic synchronization and passivity-based control frames of discrete time and space SINNs are newly formulated. Thirdly, by designing a boundary controller and constructing a Lyapunov-Krasovskii functional, we address decision theorems for stochastic synchronization and passivity-based control for the aforementioned discrete SINNs. Finally, to illustrate our main results, a numerical illustration is provided.
On a Generalization of the Kummer’s Quadratic Transformation and a Resolution of an Isolated Case
Authors: Atia Mohamed Jalel , Rathie Arjun Kumar
Published: August 2023

The resolution of isolated cases of the well-known quadratic transformation due to Kummer was thoroughly examined in two recent publications by Atia as well as Atia and Al-Mohaimeed. The objective of this paper is twofold. We establish generalizations of the quadratic transformation due to Kummer in the most general case in the first section, and in the second section, an effort is made to discuss the resolution of an isolated case of a quadratic transformation contiguous to that of Kummer established by Choi and Rathie.
Solution of a Half-Space in Generalized Thermoelastic Problem in the Context of Two Models Using the Homotopy Perturbation Method
Authors: Althobaiti Nesreen , Abo-Dahab Sayed M. , Kilany Araby Atef , Abd-Aalla Abdelmooty M.
Published: August 2023

This paper estimated the problem of one-dimensional generalized thermoelastic half-space in medium considering two models: the Lord and Shulman (LS) model and the Dual-Phase-Lag (DPL) model. We assumed that the surface of the half-space was free from traction force and under an exponentially varying external heat source at the boundary with time. The technique of homotopy perturbation has been applied to find the approximate solution for the interactions of thermoelasticity with the applied boundary condition. The effect of a heat source that varies with the time and the free traction force are investigated for the temperature, displacement, and stress. The numerical results obtained are presented graphically to show the influence of the new external parameters. The results obtained illustrate the strong impacts on the displacement, temperature, and stress with the variations in the two models as well as the relaxation time parameter. The results show the agreement between the present results and the previous obtained results of the phenomenon and applicable, especially in biology, acoustics, engineering, and geophysics.
Emerging Trends in Fast MRI Using Deep-Learning Reconstruction on Undersampled k-Space Data: A Systematic Review
Authors: Singh Dilbag , Monga Anmol , de Moura Hector L. , Zhang Xiaoxia , Zibetti Marcelo V. W. , Regatte Ravinder R.
Published: August 2023

Magnetic Resonance Imaging (MRI) is an essential medical imaging modality that provides excellent soft-tissue contrast and high-resolution images of the human body, allowing us to understand detailed information on morphology, structural integrity, and physiologic processes. However, MRI exams usually require lengthy acquisition times. Methods such as parallel MRI and Compressive Sensing (CS) have significantly reduced the MRI acquisition time by acquiring less data through undersampling k-space. The state-of-the-art of fast MRI has recently been redefined by integrating Deep Learning (DL) models with these undersampled approaches. This Systematic Literature Review (SLR) comprehensively analyzes deep MRI reconstruction models, emphasizing the key elements of recently proposed methods and highlighting their strengths and weaknesses. This SLR involves searching and selecting relevant studies from various databases, including Web of Science and Scopus, followed by a rigorous screening and data extraction process using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. It focuses on various techniques, such as residual learning, image representation using encoders and decoders, data-consistency layers, unrolled networks, learned activations, attention modules, plug-and-play priors, diffusion models, and Bayesian methods. This SLR also discusses the use of loss functions and training with adversarial networks to enhance deep MRI reconstruction methods. Moreover, we explore various MRI reconstruction applications, including non-Cartesian reconstruction, super-resolution, dynamic MRI, joint learning of reconstruction with coil sensitivity and sampling, quantitative mapping, and MR fingerprinting. This paper also addresses research questions, provides insights for future directions, and emphasizes robust generalization and artifact handling. Therefore, this SLR serves as a valuable resource for advancing fast MRI, guiding research and development efforts of MRI reconstruction for better image quality and faster data acquisition.
Joint Light-Sensitive Balanced Butterfly Optimizer for Solving the NLO and NCO Problems of WSN for Environmental Monitoring
Authors: Xia Fei , Yang Ming , Zhang Mengjian , Zhang Jing
Published: August 2023

Existing swarm intelligence (SI) optimization algorithms applied to node localization optimization (NLO) and node coverage optimization (NCO) problems have low accuracy. In this study, a novel balanced butterfly optimizer (BBO) is proposed which comprehensively considers that butterflies in nature have both smell-sensitive and light-sensitive characteristics. These smell-sensitive and light-sensitive characteristics are used for the global and local search strategies of the proposed algorithm, respectively. Notably, the value of individuals’ smell-sensitive characteristic is generally positive, which is a point that cannot be ignored. The performance of the proposed BBO is verified by twenty-three benchmark functions and compared to other state-of-the-art (SOTA) SI algorithms, including particle swarm optimization (PSO), differential evolution (DE), grey wolf optimizer (GWO), artificial butterfly optimization (ABO), butterfly optimization algorithm (BOA), Harris hawk optimization (HHO), and aquila optimizer (AO). The results demonstrate that the proposed BBO has better performance with the global search ability and strong stability. In addition, the BBO algorithm is used to address NLO and NCO problems in wireless sensor networks (WSNs) used in environmental monitoring, obtaining good results.
Resistive Gas Sensors Based on Porous Sp-Containing Films Obtained by Dehydrohalogenation of PVDC and PVDC-PVC Copolymer
Authors: Streletskiy Oleg A. , Zavidovskiy Ilya A. , Nuriahmetov Islam F. , Nishchak Olesya Y. , Pavlikov Alexander V. , Savchenko Natalya F.
Published: August 2023

Resistive sensing responses of the thin films obtained by dehydrohalogenation of polyvinylidene chloride (PVDC) and polyvinylidene chloride–polyvinyl chloride (PVDC-PVC) copolymer were investigated. The structure of the samples was studied by transmission electron microscopy, Fourier-transform infrared spectroscopy and Raman spectroscopy. The analyses demonstrate the formation of a porous structure based on polyyne–polyene chains. The formation of a foam-like oxidized sp-rich structure was observed for the samples obtained via the chemical treatment of the PVDC. However, a loose film with a developed structure and a lower fraction of sp-hybridized carbon was observed for KOH-treated PVDC-PVC. The resistive sensing responses of both of the dehydrohalogenated structures were measured for various concentrations of acetone, acetic acid, ammonia hydroxide, methanol, ethanol, benzene and water. The interplay between the efficiency of the dehydrohalogenation of the films, their structure and sensing selectivity is discussed.
Phase Formation and Properties of Multicomponent Solid Solutions Based on Ba(Ti, Zr)O3 and AgNbO3 for Environmentally Friendly High-Efficiency Energy Storage
Authors: Volkov Dmitry V. , Glazunova Ekaterina V. , Shilkina Lydia A. , Nazarenko Aleksandr V. , Pavelko Aleksey A. , Bobylev Vyacheslav A. , Reznichenko Larisa A. , Verbenko Ilya A.
Published: August 2023

This paper investigates the processes of phase formation of solid solutions of (1 − x)BaTi0.85Zr0.15O3 − xAgNbO3 where x = 0, 0.03, 0.06, 0.09. The optimal temperatures of synthesis and sintering are determined. From the results of X-ray diffraction analysis, it follows that all solid solutions have a perovskite-type structure. Analysis of the microstructure showed that the average grain size decreases at concentrations x = 0.03 and 0.06. Correlations between the cationic composition and dielectric characteristics of the studied solid solutions have been established. The values of the total stored energy and efficiency are determined. The maximum stored energy was found for a solid solution with x = 0.03 and amounted to 0.074 J∙cm−3 with an efficiency of 76.5%.
Affect Recognition, Theory of Mind, and Empathy in Preschool Children with Externalizing Behavior Problems—A Group Comparison and Developmental Psychological Consideration
Authors: Watrin-Avino Laura M. , Forbes Franziska J. , Buchwald Martin C. , Dittrich Katja , Correll Christoph U. , Bermpohl Felix , Bödeker Katja
Published: August 2023

Preschool mental disorders are often associated with significant interpersonal problems, related to impaired affect recognition, theory of mind (ToM), and empathy. To date, these skills have not been studied together in preschoolers with externalizing behavior problems (EBPs). The aim of the present study was to investigate whether and to what extent preschool children with EBPs show impairments in affect recognition, ToM, and empathy. Preschoolers with EBPs, defined by current psychiatric treatment and T-scores ≥ 60 on the externalizing problem scale of the Child Behavior Checklist (CBCL/1½-5 or 6-18R) were compared to non-clinical controls (HCs), defined by no past and no current psychiatric treatment and T-scores < 60 on all CBCL broad-band scales. Groups were compared on affect recognition (NEuroPSYchological Assessment-II), affective ToM (Test of Emotion Comprehension), cognitive ToM (Extended Theory-of-Mind Scale), parent-reported emotional contagion, attention to others’ feelings, and prosocial action (Empathy Questionnaire), IQ and language (Wechsler Preschool and Primary Scale of Intelligence-III Matrices, Active and Passive Vocabulary test), controlling for age, sex, and language abilities. Compared to 28 HCs, 22 preschoolers with EBPs (total sample meanage = 5.5 years +/− 0.8 years, range= 4.2–6.9 years, males 66%) had significantly greater impairments in cognitive ToM (p = 0.0012, η2 = 0.266), attention to others’ feelings (p = 0.0049, η2 = 0.222), and prosocial action (p = 0.0070, η2 = 0.210), each representing strong effect sizes. EBPs were significantly related to cognitive domains, like prosocial action (r = −0.501), cognitive ToM (r = −0.425), and attention to others’ feelings (r = −0.332), but not to affective domains of social cognition. Social cognitive development may be impaired as early as preschool age and should be promoted before the child starts school.
Pediatric Spinal Cord Injury: A Review
Authors: Cunha Natalia S. C. , Malvea Anahita , Sadat Sarah , Ibrahim George M. , Fehlings Michael G.
Published: August 2023

A spinal cord injury (SCI) can be a devastating condition in children, with profound implications for their overall health and quality of life. In this review, we aim to provide a concise overview of the key aspects associated with SCIs in the pediatric population. Firstly, we discuss the etiology and epidemiology of SCIs in children, highlighting the diverse range of causes. We explore the unique anatomical and physiological characteristics of the developing spinal cord that contribute to the specific challenges faced by pediatric patients. Next, we delve into the clinical presentation and diagnostic methods, emphasizing the importance of prompt and accurate diagnosis to facilitate appropriate interventions. Furthermore, we approach the multidisciplinary management of pediatric SCIs, encompassing acute medical care, surgical interventions, and ongoing supportive therapies. Finally, we explore emerging research as well as innovative therapies in the field, and we emphasize the need for continued advancements in understanding and treating SCIs in children to improve their functional independence and overall quality of life.
Testicular Adrenal Rest Tumors in Congenital Adrenal Hyperplasia: Study of a Cohort of Patients from a Single Italian Center
Authors: Ortolano Rita , Cassio Alessandra , Alqaisi Randa S. , Candela Egidio , Di Natale Valeria , Assirelli Valentina , Bernardini Luca , Bortolamedi Elisa , Cantarelli Erika , Corcioni Beniamino , Renzulli Matteo , Balsamo Antonio , Baronio Federico
Published: August 2023

Testicular adrenal rest tumors (TARTs) are a common complication in male patients with congenital adrenal hyperplasia (CAH). The aim of our cross-sectional cohort study is to estimate the frequency of TARTs with the correlation of genotype and disease control on tumor development. Thirty-five male patients, aged 14–26 years, were included in the study, all followed by the same center of pediatric endocrinology in Bologna. We studied genotypes, hormonal profiles at different time intervals and testicular ultrasound. A logistic regression model with multivariant analysis was developed for the statistical analysis. TARTs were detected in 31.4% of the cases, 90.9% of them had a classic form with salt wasting, while 9.1% had a non-classic form. Additionally, a significant correlation between the incidence of TARTs and severity of genotype was detected. Patients with TARTs had markedly worse metabolic control on average (p = 0.027), reflected by high ACTH, 17OH progesterone, and overall delta4-androstenedione. In conclusion, a screening tool is mandatory, especially (but not exclusively) in patients with the most severe forms of CAH and poor endocrine control of the disease.
Qualitative Insights into Key Angelman Syndrome Motor Related Concepts Reported by Caregivers—A Thematic Analysis of Semi-Structured Interviews
Authors: Rogers Miranda , Motola Stéphane , Bechichi Yacine , Cluzeau Céline , Terray Tanguy , Berent Allyson , Panagoulias Jennifer , Duis Jessica , Eggenspieler Damien , Servais Laurent
Published: August 2023

Previous patient-centered concept models of Angelman syndrome (AS) are integral in developing our understanding of the symptoms and impact of this condition with a holistic perspective and have highlighted the importance of motor function. We aimed to develop the motor and movement aspects of the concept models, to support research regarding motor-related digital outcomes aligned with patients’ and caregivers’ perspectives. We conducted a qualitative analysis of semi-structured interviews of 24 caregivers to explore AS motor-related features, factors influencing them and their impact on patients and caregivers.The most impacted motor features were gait, walking and stair-climbing. Half of caregivers ranked motor symptoms as one of the most burdensome symptoms of AS. Caregivers frequently reported physical therapy, motivation, medical management and age as factors influencing motor function in AS and reported that impaired motor function affected both patients and caregivers. Measures of lower-limb motor function were identified as relevant to monitor drug effectiveness in AS. Caregivers discussed expected benefits of a digital outcome and potential issues with wearable technology in the context of AS. We propose a new motor function patient-centered concept model, providing insights for the development of relevant, motor-related, digital outcomes in AS.
Pathological Effects of SARS-CoV-2 Associated with Hematological Abnormalities
Authors: Shama  , Mahmood Asif , Mehmood Shahid , Zhang Wen
Published: August 2023

The SARS coronavirus 2 (SARS-CoV-2) is the causative agent of the 2019 coronavirus disease (COVID-19) pandemic that has claimed the lives of 6.9 million people and infected over 765 million. It has become a major worldwide health problem and is also known to cause abnormalities in various systems, including the hematologic system. COVID-19 infection primarily affects the lower respiratory tract and can lead to a cascade of events, including a cytokine storm, intravascular thrombosis, and subsequent complications such as arterial and venous thromboses. COVID-19 can cause thrombocytopenia, lymphopenia, and neutrophilia, which are associated with worse outcomes. Prophylactic anticoagulation is essential to prevent complications and death rates associated with the virus’s effect on the coagulation system. It is crucial to recognize these complications early and promptly start therapeutic anticoagulation to improve patient outcomes. While rare, COVID-19-induced disseminated intravascular coagulation (DIC) exhibits some similarities to DIC induced by sepsis. Lactate dehydrogenase (LDH), D-dimer, ferritin, and C-reactive protein (CRP) biomarkers often increase in serious COVID-19 cases and poor prognosis. Understanding the pathophysiology of the disease and identifying risk factors for adverse outcomes is critical for effective management of COVID-19.
Preoperative Embolization of Vertebral Metastasis: Comprehensive Review of the Literature
Authors: Faiella Eliodoro , Santucci Domiziana , Vertulli Daniele , Russo Fabrizio , Vadalà Gianluca , Papalia Rocco , Beomonte Zobel Bruno , Denaro Vincenzo , Grasso Rosario Francesco
Published: August 2023

The aim of this review is to determine the safety and efficacy of pre-operative spinal metastases embolization procedures. Two reviewers independently conducted the literature search (on MEDLINE databases), including in the review of all the studies that used pre-operative TAE to treat spinal metastases. Twelve articles on pre-operative spinal metastases embolization were selected. Most of the studies demonstrated the low complication rate of pre-operative embolization. The most important study strength is that there are very few reviews in the literature with the setting on pre-operative vertebral metastases embolization. A limitation of the review is that the studies included were predominately retrospective case-control studies, increasing the risk of bias in the primary data. Plus, divergent surgical and embolization procedures were performed in the studies, causing a potential risk of bias in the pooled results. We can conclude that preoperative arterial embolization of vertebral metastases is a safe, well-tolerated technique that reduces surgical blood loss and facilitates surgical tumor resection.
Security Supply Chain Using UAVs: Validation and Development of a UAV-Based Model for Qatar’s Mega Sporting Events
Authors: AL-Dosari Khalifa , Deif Ahmed M. , Kucukvar Murat , Onat Nuri , Fetais Noora
Published: August 2023

Unmanned aircraft vehicles (UAVs) are now used to support security precautions in search and rescue operations to track and evaluate critical services, to provide cybersecurity measures by transporting security supply chain management (SCM) to sports events, and to aid efforts to safeguard the spectators from attacks. A drone may quickly fly over sports grounds, scan the area for potential dangers, and offer aerial footage and still photographs. Although UAVs provide benefits to their operators, there is a possibility that they may also pose cybersecurity threats. This guide offers recommendations for best security practices, intending to assist sports operators in protecting their networks, materials, and staff for Qatar’s mega sporting events. The literature comprises several theoretical frameworks and conceptual models for security supply chains. Unfortunately, there is no practical model for measuring the behavioral intentions of professional IT and security experts. Therefore, this study conducted research in two stages. In the first stage, an in-depth systematic literature review was conducted to identify the factors and themes of UAV-based SCM for security measures. In the second phase, a survey questionnaire (N = 712) was implemented, comprising the themes and items from the literature review among professional IT and security experts. Exploratory factor analysis (EFA) was carried out with IBM SPSS, and confirmatory factor analysis (CFA) was employed with IBM AMOS. This study proposed and developed a UAV-based SCM model to provide security for Qatar’s mega sporting events, which comprised five factors: traceability, security and privacy, trust, acceptability, and preparedness. This study also confirmed the validity and reliability of the newly developed scales, offering practical and proposed implications for the IT and security industries. The key findings of the study are: (1) a valid and reliable UAV-based cybersecurity framework for FIFA mega sporting events was developed; (2) five critical factors were identified, including traceability, security and privacy, trust, acceptability, and preparedness; (3) all factors were significantly and positively correlated, highlighting the complexity of managing security systems in mega sporting events.
Affective Economy: A Theoretical Outline
Authors: Fontefrancesco Michele Filippo
Published: August 2023

The affective economy is a concept that emerged within the field of social sciences, focusing on the interplay between emotions, affects, and economic processes. It explores how emotions and affective experiences shape economic practices, consumption patterns, and the production of goods and services. In the affective economy framework, emotions are seen as not merely individual but deeply embedded in social and political contexts, shaping and being shaped by social structures and power dynamics. The affective economy emphasizes how emotions circulate and contribute to the construction and maintenance of social orders, impacting economic actions. It acknowledges the profound impact of emotions and affects on economic behavior. Thus, this concept sheds light on the intricate relationship between emotions and economic processes, demonstrating how affective experiences influence consumption, production, labor, financial decisions, and the overall dynamics of the market economy. It emphasizes the need for a more nuanced understanding of human behavior in economic contexts, recognizing the significance of emotions and affective responses as integral components of economic activities. This concept is connected to notions of dwelling, topophilia, and affective atmospheres, providing insights into the complexities of economic transactions in diverse cultural contexts.
Major- and Trace-Element Geochemistry of Geothermal Water from the Nappe Zone, Northern Tunisia: Implications for Mineral Prospecting and Health Risk Assessment
Authors: Ayari Jamel , Barbieri Maurizio , Boschetti Tiziano , Barhoumi Anis , Sellami Ahmed , Braham Ahmed , Manai Faouzi , Dhaha Faouzi , Charef Abdelkarim
Published: August 2023

A comprehensive hydrogeochemical survey of the geothermal waters from the Nappe Zone (Maghrebides fold-and-thrust belt) was undertaken to determine the origins of geothermal waters and to assess the health risks associated with their potentially toxic elements. A total of 11 geothermal water and 3 stream water samples were collected and analysed for major and trace elements (As, B, Ba, Fe, Mn, Pb, Sr, Zn). Two main geothermal water groups were highlighted by hydrogeochemical diagrams and multivariate analyses (PCA, HCA): the first group is the Na−Cl type, TDS > 10 g/L, controlled by deep circulation, while the second group is the Na-Cl−HCO3 type, TDS < 2 g/L, and controlled by shallow circulation. A curved hydrogeochemical evolution path, observed from mixed bicarbonate shallow groundwater to chloride geothermal water, indicates that the interaction with evaporites drives the chemistry of the geothermal samples. On these, the As enrichments come from sulphide oxidation polymetallic mineralisation during the upwelling to the surface from E–W major lineaments. Therefore, E–W lineaments are potential areas for mineral prospecting. The health risk assessment reveals that the concentration of potentially toxic elements in geothermal waters are lower than the guideline values for the protection of freshwater aquatic life and dermal exposure (bathing or balneology).
Lactic Acid Production from Steam-Exploded Sugarcane Bagasse Using Bacillus coagulans DSM2314
Authors: Alves William Rodrigues , da Silva Thiago Alessandre , Zandoná Filho Arion , Pereira Ramos Luiz
Published: August 2023

This work aimed at producing lactic acid (LA) from sugarcane bagasse after steam explosion at 195 °C for 7.5 and 15 min. Enzymatic hydrolysis was carried out with Cellic CTec3 and Cellic HTec3 (Novozymes), whereas fermentation was performed with Bacillus coagulans DSM2314. Water washing of pretreated solids before enzymatic hydrolysis improved both hydrolysis and fermentation yields. The presence of xylo-oligosaccharides (XOS) in substrate hydrolysates reduced hydrolysis efficiency, but their effect on fermentation was negligible. The presence of fermentation inhibitors in C5 streams was circumvented by adsorption on activated carbon powder with no detectable sugar losses. High carbohydrates-to-LA conversions (Yp/s) of 0.88 g·g−1 were obtained from enzymatic hydrolysates of water-washed steam-exploded materials that were produced at 195 °C, in 7.5 min, and the use of centrifuged-but-never-washed pretreated solids decreased Yp/s by 16%. However, when the detoxified C5 stream was added at a 10% ratio, Yp/s was raised to 0.93 g·g−1 for an LA productivity of 2.55 g·L−1·h−1. Doubling the pretreatment time caused a decrease in Yp/s to 0.78 g·g−1, but LA productivity was the highest (3.20 g·L−1·h−1). For pretreatment at 195 °C for 7.5 min, the elimination of water washing seemed feasible, but the use of longer pretreatment times made it mandatory to eliminate fermentation inhibitors.
The Antioxidant Potential of Fermented Foods: Challenges and Future Trends
Authors: Verni Michela , Rizzello Carlo Giuseppe
Published: August 2023

The major roles of antioxidant compounds in preserving food shelf-life, as well as in providing health-promoting benefits, combined with the increasing concern regarding synthetic antioxidants, is progressively leading the scientific community to focus on natural antioxidants [...]
Investigations for a Yarrowia-Based Biorefinery: In Vitro Proof-of-Concept for Manufacturing Sweetener, Cosmetic Ingredient, and Bioemulsifier
Authors: Eszterbauer Edina , Németh Áron
Published: August 2023

Yarrowia lipolytica is a widely used microorganism in biotechnology since it is capable of producing a wide range of products (lipase, citric acid, polyols). A less-studied related strain is Y. divulgata, which is also capable of erythritol production in even higher concentration than most Y. lipolytica wild strains from glycerol as renewable feedstock. Thus, the aim of this work was to investigate Y. divulgata’s complex utilisation based on erythritol fermentation from glycerol to establish a Yarrowia-based biorefinery in which both the fermentation broth and separated cells are converted into high added-value products (erythritol, bioemulsifier, cosmetic ingredient, i.e., skin moisturizer). An important parameter of erythritol fermentation is an adequate oxygen level, so both the constant oxygen level and oxygen absorption rate were investigated regarding the three target products. DO (dissolved oxygen) = 10, 20, 30, 40% was examined in the bioreactor, and a KLa range of 18–655 h−1 was investigated in both the bioreactor and in different types of shaking flasks, applying two different glycerol levels (100–150 g/L). The results showed that the Yarrowia divulagata NCAIM 1485 strain could produce one of the highest amounts of erythritol (44.14 ± 1 g/L) among wild-type yeasts from 150 g/L glycerol beside a KLa value of 655 h−1. Cell-lysates skin hydrating activity was the highest (12%) when DO = 20% (KLa 26.4 h−1) was applied. In all cases, the collected samples had an emulsification index above 69% which did not decrease below 54% after 24 h, showing good stability. Since Y. divulgata fermentations resulted in three high added-value products at the same time from a renewable raw material (glycerol), we concluded that it is suitable for complex utilisation in a microbial biorefinery, since the fermentation broth can be used for the isolation of a sweetener and bioemulsifier; meanwhile, the separated cells can be processed for cosmetic application as a skin moisturizer.
Forest Fire Driving Factors and Fire Risk Zoning Based on an Optimal Parameter Logistic Regression Model: A Case Study of the Liangshan Yi Autonomous Prefecture, China
Authors: Zhang Fuhuan , Zhang Bin , Luo Jun , Liu Hui , Deng Qingchun , Wang Lei , Zuo Ziquan
Published: August 2023

Planning the analyses of the spatial distribution and driving factors of forest fires and regionalizing fire risks is an important part of forest fire management. Based on the Landsat-8 active fire dataset of the Liangshan Yi Autonomous Prefecture from 2014 to 2021, this paper proposes an optimal parameter logistic regression (OPLR) model, conducts forest fire risk zoning research under the optimal spatial analysis scale and model parameters, and establishes a forest fire risk prediction model. The results showed that the spatial unit of the optimal spatial analysis scale in the study area was 5 km and that the prediction accuracy of the OPLR was about 81%. The climate was the main driving factor of forest fires, while temperature had the greatest influence on the probability of forest fires. According to the forest fire prediction model, mapping the fire risk zoning, in which the medium- and high-risk area was 6021.13 km2, accounted for 9.99% of the study area. The results contribute to a better understanding of forest fire management based on the local environmental characteristics of the Liangshan Yi Autonomous Prefecture and provide a reference for related forest fire prevention and control management.