bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of Alcohol Content in A Herbal Medicine of Noni Using Gas Chromatography Method
Authors: RS Qomariyah , Roswiem Anna Priangani , Suseno Dedy
Published: August 2022

Noni (Morinda citrifolia L) has long been used for herbal medicine to treat various medical conditions, such as arthritis, diabetes, hypertension, arteriosclerosis, heart disease, blood vessel problems, tumour and cancer. One of the compound in some fruit is ethanol. Ethanol in the pharmaceutical industry is often used as a solvent. Regulation of the Head of the National Agency of Drug and Food Control of the Republic of Indonesia (BPOM RI) Number HK.03.1.23.06.10.5166 Year 2010 states that alcohol-containing drugs, traditional medicines, and supplements must declare the alcohol content (in percentage) on the label. There are many available noni herbal medicines on Indonesia's market, either with or without a distribution license. This research aims to analyse alcohol content, product type, distribution licence, and label of alcohol content on noni herbal medicines from herbal drugstores or online shops in Jakarta. Determination of alcohol content in this study was performed using Gas Chromatography Headspace method. The result showed that 13 out of 20 samples contained alcohol ranging between 0.04 - 1.07%. None of the samples with detected alcohol had a label "contains alcohol in per cent (%)". Eighteen samples were categorised as "beverages" and two samples were categorised as "traditional medicines or herbal medicines". These two samples contain 0.21 and 0.07% alcohol. In accordence with the Fatwa of the Indonesian Council of Ulama, these herbal medicines are "allowed" to be consumed with certain conditions: the medicines do not endanger the health and do not encourage substance abuse, their use must follow the recommended dosage and they should not be used intentionally to get drunk. Out of 18 samples within the "beverage" category, only 12 samples were halal; the other 6 were haram.
Factors Affecting the Successful Implementation of MS1500 by Malaysian Halal Food Industry
Authors: Sari Dian Permata , Jaswir Irwandi , Bin Haji Che Daud Mohd. Radzi
Published: August 2022

Since no specific Halal Act has been established and applied by Malaysian Government yet, up to this day Malaysian Standard, MS1500 is the only basic reference to issue a Halal Certificate for Halal Food which should applied by the legal authority such as JAKIM (Jabatan Kemajuan Islam Malaysia) and State Islamic religious council. Therefore, Malaysian Government is eager to see the successful implementation this MS as their leading Halal Standard. However, there are many problems and challenges that frequently lead to unsuccessful execution of implementation of this MS. Accordingly, this study aims to identify the factors affecting the successful implementation of MS1500 thoroughly. A series of analysis had been performed: started with data preparation and screening followed by Exploratory Factor Analysis (EFA) and reliability test. The next steps of analysis are Confirmatory Factor Analysis (CFA) and Validity Test. This study identified that Perception On Implementation (POI), Halal Control System Activity (HCSA) and Owner, Management, Employee Limitation (OMEL) are the factors affecting the successful of Implementation of MS1500. On top of that, it was also found that in Malaysia, finance and regulation were not the factors that cause the limitation on implementation of Halal Food Standard.
FIBRODISPLASIA OSSIFICANTE PROGRESSIVA EM PEDIATRIA: REVISÃO INTEGRATIVA COM FOCO NA ENFERMAGEM
Authors: Dias Sylvia Carriel , Freire Márcia Helena de Souza , Saganski Gabrielle Freitas
Published: August 2022

Objetivo: identificar as ações de cuidado/assistência de enfermagem ao paciente pediátrico com FOP na Atenção Primária à Saúde. Método: revisão integrativa, com as buscas realizadas em outubro de 2020, em cinco bases de dados e literatura cinzenta. Com descritores nacionais e internacionais. A seleção dos estudos foi realizada por revisores independentes. Resultados: a partir de uma busca ampla foram identificados 1213 estudos e incluídos 2 artigos na amostra final. Seguiu-se três direcionamentos temáticos assistenciais: Contribuições de enfermagem no reconhecimento precoce da doença, a importância da educação em saúde, e a prevenção de traumatismos. Conclusão: os resultados obtidos agregaram conhecimento acerca da assistência aos pacientes pediátricos com FOP.  Estudos científicos acerca dos cuidados de enfermagem a essa doença ainda são escassos, assim recomenda-se o desenvolvimento de novos estudos visto a significância do papel da enfermagem às doenças raras.
Variabilité climatique en Afrique de l'Ouest : incidence de l'aide publique au développment sur la sécurité alimentaire
Authors: Dandonougbo Yevessé , Agbodji Ega Akoété
Published: August 2022

L ' objectif de ce papier est d ' évaluer l ' effet de l ' aide publique au développement dans l ' atténuation des effets de la variabilité climatique sur la sécurité alimentaire des pays de l ' Afrique de l ' ouest. En utilisant les données de panel sur 14 pays au cours de la période de 1990 à 2016, les résultats des estimations économétriques révèlent que l ' effet négatif de la variabilité des précipitations sur l ' approvisionnement alimentaires des pays de la zones ' atténue indirectement avec l ' aide publique au développement. Par ailleurs, l ' aide publique au développement quant à elle seule semble n ' avoir pas d ' effet significatif sur l ' approvisionnement alimentaire des pays de la zone essentiellement agricole. Ainsi, l ' aide publique au développement constitue un facteur d ' atténuation des effets du changement climatique et devrait être plus considérer dans les politiques d ' adaptation au changement climatique afin de réduire les effets de ce dernier sur la sécurité alimentaire des pays de la zone.
Taux de taxation optimale et croissance économique : une application empirique au cas du Liban
Authors: Ghossoub Sayegh Rosette , Hamdan Saade Nisrine
Published: August 2022

De nombreuses études mettent en évidence l ' impact significatif de la politique fiscale sur le taux de croissance économique, dans les pays présentant une situation financière et économique précaire, similaire au cas libanais. Une étude empirique, couvrant la période 1971-2017, est menée dans cet article, pour déterminer la pression fiscale optimale qui maximise le taux de croissance économique au Liban. Une relation de non-linéarité entre le fardeau fiscal et la croissance économique est alors examinée, à travers le modèle statique de Scully (1996, 2003). En considérant les périodes de conflits politiques et d ' instabilités économiques du pays, les estimations du modèle économétrique aboutissent à un taux de pression fiscale optimal de 20,62%.
Perspectivas clínicas psicológicas de caso
Authors: Córdoba Salamanca Karoll , Pardo Pérez Fabián Ricardo , Noguera Morales Tatiana
Published: August 2022

¿Es la psicología una disciplina con una única perspectiva para el acercamiento a su objeto de estudio? Esta pregunta, que parece dirigida a la epistemología y a los psicólogos dedicados a estas discusiones teoréticas, no ha logrado ser resuelta de forma concreta, por lo que, a modo de efecto secundario, amplía las posibilidades de comprensión y explicación del fenómeno mental. Ahora bien, al trasladar esta pregunta a los procesos de formación en psicología se han generado una serie de retos que la dialéctica entre la educación y la sociedad ha procurado abarcar mediante la profundización en diversas temáticas o propuestas formativas. Sin embargo, en esta tensión sociedad-educación, uno de los escenarios más relevantes se encuentra en los semestres de práctica profesional, momento en el cual los profesores y los estudiantes se enfrentan a preguntas y problemas cotidianos que demandan una respuesta efectiva y acertada que supera la reflexión filosófica al tiempo que identifica las nuevas demandas del contexto.
Desain Model Monate: Movie Analysis and Debate untuk Pembelajaran Literasi Sosial
Authors: Utami Fariza Wahyu , Wardani Li’anatus Sukma , Segara Nuansa Bayu
Published: August 2022

Literacy skills in the 21st century for the cognitive development of any student are vital. Various literacy skills are a derivative of 21st-century skills. Social literacy is one of the goals of the social studies learning process. It is also necessary to improving supporting abilities such as the ability to communicate, collaborate and think critically for each student. They can mount their competencies through learning experiences from the surrounding environment. One of the innovations is for improving students' social literacy skills in social studies learning is using the "MONATE" (Movie Analysis and Debate) learning model. The "MONATE" learning model uses films as a form of material delivery as innovative learning. The method used in developing this Learning Model is ADDIE (analysis, design, develop, implement, evaluate). In this article, we only discuss the progress stage of the development of this MONATE Model. The analysis stage is out by conducting a literature study related to social studies learning competencies. The design stage is a process to design a learning model that is by the learning objectives. The development stage is out by validating the social studies learning model developer experts for a desk appraise. The result is that there are several model developments, especially in the learning syntax and learning media used. The improvement of this model becomes the basis for conducting further research processes.
Demografi dan Kompetensi Pengembangan Instrumen Penilaian Hasil Belajar Berbasis Higher Order Thinking Skills Guru Ilmu Pengetahuan Sosial
Authors: Wahidmurni Wahidmurni , Yuniar Marandy Setyo , Zuhrotul Hani’ah
Published: August 2022

The research aims to investigate: (1) the content of higher-order thinking skills (HOTS) in basic competence verbs and learning assessment instruments prepared by teachers, (2) the aspect of demography and teacher competency in developing HOTSbased learning assessment instrument, and (3) teacher’s problems in developing HOTS based learning assessment instrument. To accomplish the aims, the researchers employed a mixed-method approach and Convergence Model design. The data collection involves interviews with teachers, documentation and questionnaire. Quantitative data were analyzed using percentage technique. Meanwhile, the qualitative ones were analyzed using condensation patterns, data presentation, and conclusion drawing. The result of the research shows that: (1) Most of the basic competence verbs in the curriculum of social studies subject contain HOTS, but only a few of HOTS-based assessment instruments are employed, (2) demographically, most teachers have an irrelevant educational background and have not been trained before. Even though most of them are professional teachers, their understanding and competencies in developing HOTS-based assessment instruments are still low, and (3) the main problem faced by teachers is their incompetence in developing basic competency verbs into suitable operational verbs of social studies. It indicates the urgency of assistance and training for teachers to improve their competencies in developing this instrument.
The Influence of Economic Literacy and Lifestyle on the Consumptive Behavior of Students
Authors: Firdaus Ahmad Bachtiar , Pusposari Luthfiya Fathi
Published: August 2022

This research aims to analyze the effect of economic literacy and life style on consumer behavior social science student who has active as student social science UIN Malang at 2019 grade. This research is quantitative research. The data collection techniques using questionnaires. The population is 108 students, and use 85 students as samples which elected by proportional random sampling. this research was analyzed using multiple linier regression. The results of the study are (1) economics literacy has significant negative effect on customer behavior (2) live style has significant positive effect on consumptive behavior (3) economics literacy and live style have positive effect on consumptive behavior.
El efecto de la polisemia y las construcciones de se + clítico en la variación en los clíticos de tercera persona con el verbo llamar
Authors:   Universidad Nacional Autónoma de México, Facultad de Filosofía y Letras, Mexico, Vargas Manzano Ángel
Published: August 2022

This paper describes the linguistic situation presented by the third person clitics used to refer to the direct object of the verb llamarwith data from Mexican Spanish. In the Hispanic grammatical tradition, studies on the phenomenon of the variation of third person clitics have focused on describing how their variability works in a general way with different types of verbs, however, there are very few analyzes in which a detailed study is made with a verb to observe the behavior of its clitics. Although the norm recommends expressing the direct object of the verb llamar with the clitics lo(s) and la(s), this verb has presented variation since its origins, it means, there is also the possibility of using the clitics le(s). The analysis of the data indicates that in Mexico there is a tendency to favor leísta solutions with this verb and this is mainly motivated by the “designativa” meaning of the verb, as well as by the use of se + clitic constructions.
Znaczenie wprowadzania art. 12 § 2 k.k. i art. 57b k.k. dla praktyki wymiaru sprawiedliwości
Authors: Kluza Jan
Published: August 2022

Przedmiotem artykułu jest omówienie kwestii zmian dokonanych w kodeksie karnym w zakresie odpowiedzialności karnej za zachowania podejmowane w krótkich odstępach czasu. W art. 12 § 2 k.k. ustawodawca wprowadził nowy przepis, na podstawie którego w razie zrealizowania określonych w nim warunków, sprawca kilku wykroczeń odpowiada jak za przestępstwo. Na tle tego sformułowania zachodzą istotne wątpliwości co do jego prawidłowego stosowania i wynikłych stąd konsekwencji. Z kolei nowelizacją z 2020 roku ustawodawca wprowadził do kodeksu art. 57b k.k., na podstawie którego sąd obowiązkowo musi wymierzyć surowszą karę za czyn ciągły. Konsekwencje tej zmiany są jednak dalej idące, co zostanie przestawione w artykule.
Rozkaz wojskowy jako okoliczność wyłączająca winę — analiza teoretyczno-dogmatyczna wybranych aspektów
Authors: Kiełbas Dominika
Published: August 2022

Instytucja wyłączenia przestępności czynu zabronionego w warunkach wykonania polecenia ewoluowała na przestrzeni lat. Odgrywa ona niezwykle ważną rolę z punktu widzenia gwarancyjnej funkcji prawa karnego. Jest też swoistym potwierdzeniem znaczenia zasady posłuszeństwa w strukturach wojskowych, a także w innych jednostkach, do których regulujące ją przepisy stosuje się we właściwy sposób. Obowiązująca regulacja odnosi się do zasady umiarkowanego posłuszeństwa będącej gałęzią teorii „myślących bagnetów”. Analiza krajowych i międzynarodowych norm prawnych, a także doktryny i orzecznictwa pozwala na wyciągnięcie wniosku, że wykonanie rozkazu stanowi szczególną okoliczność wyłączającą winę, przypominającą nieco regulację dotyczącą kolizji obowiązków. Art. 318 k.k. nie wyłącza winy sprawcy w przypadku, gdy popełnia on przestępstwo umyślnie. Mówimy tu o sytuacji, w której żołnierz chce lub godzi się na realizację działania noszącego znamiona typu czynu zabronionego i realizuje je, choćby nie zdawał sobie sprawy z bezprawności swojego zachowania. Fakt, że sprawcą jest żołnierz wykonujący rozkaz, nie wyklucza jednak zastosowania przepisów części ogólnej uchylających przestępność. W związku z tym przy uwzględnieniu wspomnianych czynników i spełnieniu odpowiednich przesłanek można wyłączyć winę lub bezprawność czynu na zasadach ogólnych.
Kara ograniczenia wolności w świetle zmian po uchwaleniu ustawy z dnia 20 lutego 2015 roku o zmianie ustawy — Kodeks karny oraz niektórych innych ustaw, a także ustawy z dnia 11 marca 2016 roku o zmianie ustawy
Authors: Cendrowska Monika
Published: August 2022

Publikacja poświęcona jest zmianom, którym kara ograniczenia wolności podległa na przełomie lat 2015–2016. W tym okresie zostały uchwalone dwie ustawy: z dnia 20 lutego 2015 roku o zmianie ustawy — Kodeks karny oraz niektórych innych ustaw, a następnie z dnia 11 marca 2016 roku o zmianie ustawy — Kodeks postępowania karnego oraz niektórych innych ustaw. W opracowaniu przedstawiono kierunek zmian, który nadaje karze ograniczenia wolności poważną rangę w realizacji zadań polityki kryminalnej. Nowa formuła kary ograniczenia wolności spełnia najistotniejsze cele kary, a więc retrybutywny oraz prewencyjny, jednocześnie nie obciąża państwa w ponoszeniu kosztów, jakie wiążą się z izolacją penitencjarną. Kara ograniczenia wolności, będąc jednym z podstawowych środków, stanowi w nowej regulacji skuteczne narzędzie do walki z drobną i średnią przestępczością.
Prawo więźnia do ochrony zdrowia i godnej śmierci w warunkach tak zwanego dożywocia realnego
Authors: Stępniak Piotr
Published: August 2022

Autor artykułu przygląda się wybranym problemom opieki medycznej nad osobami odbywającymi kary dożywotniego pozbawienia wolności. Analizuje celowość jej świadczenia, a także rodzaj i zakres w relacji do eliminacyjnej funkcji tej kary. Wskazuje, że taką funkcję kara ta spełnia w przypadku obostrzenia przez sąd meriti formalnej przesłanki do warunkowego przedterminowego zwolnienia ponad 25 lat (art. 77 § 2 k.k.). W takim kontekście analizuje problem realizacji prawa do ochrony zdrowia skazanego oraz godnej śmierci. Analizę opiera na wyrokach określających quantum odbytej kary na lat 50. W konkluzjach wskazuje, że pomoc medyczna jest niewystarczająca, zaś skazani umierają w warunkach naruszających ich godność. Autor opowiada się za wykreśleniem art. 77 § 2 k.k., ponieważ umożliwia on sądom orzekanie kary dożywotniego pozbawienia wolności w formie bezwzględnej. Zgłasza także postulat warunkowego przedterminowego zwolnienia ze względów humanitarnych.
Przerwa w karze w świetle orzecznictwa Sądu Najwyższego i sądów apelacyjnych. Przegląd judykatów za lata 2020–2021
Authors: Mrozek Kamila
Published: August 2022

Praca poświęcona jest analizie orzecznictwa sądowego (Sąd Najwyższy oraz wybrane sądy apelacyjne) w zakresie dotyczącym instytucji przerwy w wykonaniu kary pozbawienia wolności. W obszarze zainteresowania autorki pozostawały jedynie najnowsze judykaty wydane w latach 2020–2021. W celu poprawy czytelności tekstu analiza konkretnego orzeczenia rozpoczyna się od zacytowania jego tezy, która to następnie opatrzona jest krótkim komentarzem. Omówione postanowienia koncentrują się wokół najważniejszych problemów, jakie powstają w związku z praktycznym wykorzystaniem przerwy w karze.
IMAGE COMPARISON ON T2 QTSE LUMBAL EXAMINATION USING GRAPPA TECHNIQUE WITH AND WITHOUT MAGNETIZATION TRANSFER CONTRAST IN DEGENERATIVE DISC DISEASE CASE
Authors: Arief Apriliani Karina Sandra , Utomo Sri Andreani , Muhaimin  , Muqmiroh Lailatul
Published: August 2022

Background: The description of Degenerative Disc Disease in MRI lumbar FSE sequence T2WI is seen as a decrease in signal intensity. Patients with cases of Degenerative Disc Disease experience severe low back pain and cannot lie supine for a long time, while MRI is very sensitive to movement. GRAPPA is a parallel imaging technique that can produce images with a fast scan time but is followed by a decreased Signal to Noise Ratio SNR value. This technique needs to be followed by setting other parameters to produce an optimal image, namely by applying Magnetization Transfer Contrast (MTC). Purpose: To compare the quality of image results on lumbar MRI examination of the sagittal T2 qTSE sequence in the case of Degenerative Disc Disease with and without MTC activation. Method: This research was conducted at the dr. Soedono Madiun from August to September 2020. A sample of 16 patients who met the inclusion criteria was taken during the study. The GRAPPA and GRAPPA+MTC technique imagery results on each sample were assessed for the image quality quantitatively based on the SNR and CNR values. Result: Based on the SNR value, the GRAPPA technique and MTC activation have a higher mean than the GRAPPA technique alone. Likewise, with the CNR value, the GRAPPA technique and MTC activation have a higher average than the GRAPPA technique alone. Conclusion: The GRAPPA technique and MTC activation can be applied in Lumbar MRI examination with cases of Degenerative Disc Disease, especially in uncooperative patients.
Comparison of Autologous Blood Coagulum (ABC) and Suture at Recurrence Rate and Graft Stability of Postoperative Primary Pterygium Using Conjunctival Autograft: A Meta-Analysis From Randomized Controlled Trial
Authors: Kartika Amelia Rahmah , Putra Made Angga , Lutfi Delfitri
Published: August 2022

Introduction: The main challenge of pterygium management is the postoperative recurrence rate. Currently, the use of surgical sutures for conjunctival autograft fixation, which has prolonged surgery duration, has a risk of increased inflammation and infection. Recently, some reports about autologous blood coagulum (ABC) for conjunctival autograft fixation. This technique has a minimal cost and minimal risk of infection. Purpose: The study aimed to evaluate the postoperative recurrence rate and graft stability after using ABC and sutures. Methods: A systematic research was done on Pubmed, Cochrane Library, and Science Direct online databases for all relevant randomized controlled trials (RCTs) up to 18 July 2020. The collected RCTs were independently screened and identified to match the inclusion criteria. The relevant data were compiled in population, intervention, control, outcomes (PICOs) format and analyzed with Review Manager 5.3 software. Results: Nine RCTs involving a total of 764 patients were assessed. The primary outcome indicates that ABC significantly reduced the recurrence rate compared to sutures (RR = 0.51, 95% CI 0.27 to 0.98, p = 0.04). Meanwhile, in graft stability, the suture was statistically better than ABC (RR = 1.95, 95% CI 1.27 to 3.01, p = 0.002). As a secondary outcome, the duration of surgery was significantly shorter in ABC than in sutures (MD -15.22, 95% CI -22.57 to -7.88, p<0.0001). Conclusions: Although the graft is less stable, ABC may be a promising approach after pterygium excision. The use of autologous blood for conjunctival autograft fixation in primary pterygium was associated with a lower recurrence rate and shorter duration of surgery.
Posterior Capsule Opacification (PCO) Cases at Lamongan Eye Clinic: Two Years of Retrospective Data
Authors: Suryani Irma , Unari Uyik
Published: August 2022

Introduction: Posterior capsular opacity (PCO) is the most common complication of cataract surgery. PCO is caused by the lens epithelial cells (LEC), which then proliferate in the capsular bag after surgery. Several complications can occur, such as increased intraocular pressure (IOP), cystoid macular edema (CME), retinal hemorrhage, retinal detachment, and implanted lens (IOL) damage. Capsule Nd:YAG laser is currently the standard procedure for treating PCO, with a success rate of 95%. Purpose: This study aimed to provide an overview of PCO incidence and the success rate of PCO handling in the eye clinic. Methods: This study was a retrospective observational study. Data was taken from medical records of patients diagnosed with PCO who came to the Lamongan Eye Clinic for two years (May 2018 to April 2020). Data regarding the profile of the subject was analyzed descriptively. The data distribution was tested using the Kolmogorov-Smirnov test. Results: From May 2018 to April 2020, 134 patients with PCO came to the Lamongan Eye Clinic. Mean pre-laser best-corrected visual acuity (BCVA) was 0.76 ± 0.44 (logMAR), post-laser was 0.40 ± 0.40 (logMAR). There was a significant difference in the mean refraction correction of the PCO patients before and after Nd:YAG laser capsulotomy, whereas the mean BCVA after undergoing YAG laser was higher than before. Mean pre-laser IOP was 15.00 ± 3.55 mmHg and post-laser was 14.20 ± 3.27 mmHg. The mean post-laser IOP was lower than the pre-laser IOP. The Nd:YAG laser capsulotomy significantly affected IOP. Conclusions: There is a statistically significant improvement in BCVA before and after capsulotomy. Capsulotomy had a significant effect on improving BCVA up to 7%; however, had no effect on IOP.
Bilateral Optic Neuritis as an Atypical Presentation of Primary Sjögren’s Syndrome (pSS)
Authors: Rosati Denisa , Agustini Lukisiari
Published: August 2022

Introduction: Primary Sjögren’s syndrome (pSS) is a chronic progressive autoimmune disease that primarily affects exocrine glands with varying symptoms. Here we discuss atypical optic neuritis as an initial presentation of pSS without any sicca symptoms. Case presentation: A 22-year-old woman came to the outpatient clinic with the chief complaint of rapid deteriorating visual acuity that had started one week before—no complaint of the eye or other mucosal dryness. At the initial visit, best corrected visual acuity (BCVA) was hand movement on the right eye and 6/7.5 on the left eye with decreasing color perception. Fundus examination showed bilateral optic nerve head edema. Schirmer test and tear-film break up time were within normal limits. After the initial one gram intravenous methylprednisolone treatment, no significant changes were observed for three consecutive days. Serological investigations revealed raised levels of SS-A native. Improvement happened after being given azathioprine. Conclusion: Optic neuritis may be the initial presentation of Sjögren’s syndrome without sicca symptoms. The presence of a specific antibody, including anti-SSA, is supportive for the diagnosis of such a case.
Traumatic Globe Luxation: When to Save It?
Authors: Rayungsista Awina , Fatmariyanti Susy
Published: August 2022

Introduction: Globe luxation is a rare case and is one of the trauma conditions contributing to the number of blindness worldwide. Its etiology is divided into three categories: spontaneous, voluntary, and post-traumatic. Case presentation: A 21-year-old man was referred with a chief complaint of left eye protruding and painful blind eye after a car accident 12 hours before being consulted. Systemic condition revealed anemia with bilateral pneumonia and was confirmed as COVID-19, an asymptomatic condition. Visual acuity of both eyes was > 2/60 lying position with no light perception, respectively. During surgery, we found necrotic ocular surface and choroidal prolapse. Enucleation was chosen because of poor eyeball conditions and no visual potential. Conclusion: In multiple trauma cases, either eye or systemic conditions must be considered. Although saving the eyeball is the primary treatment choice, enucleation should be considered if the eyeball’s condition is poor and has no visual potential.
Diagnosis and Therapy of Psychosomatic Disorders in Reproductive Cycle of Women in General Medical Practice (Review)
Authors: Medvedev V. E.
Published: August 2022

The incidence of different psychiatric disorders (affective, anxious, dysmorphic, psychotic) during menstruation, pregnancy and the postpartum period reaches 80 %. Mental disorders are risk factors for the delayed onset and shortening of menstruations, manifestation of the premenstrual syndrome (PMS), inadequate emotional reactions during menstruations, disruptions in the menstrual cycle, decreased regularity and satisfaction of sexual activity, fertility, pregnancy failure, reduction of the lactation period, early onset of menopause with long duration and clinical severity of premenopause, etc. An individual approach to treatment should take into account risk factors (heredity, comorbid disorders, sex, age, etc.) of adverse events (AD), the balance of efficacy and safety of drugs
The fortieth anniversary of the death of Dr. Tadeusz Kamza – a urologist from Poznan. Contribution to the collective portrait of doctors in the People’s Republic of Poland
Authors: Bogusz Halina
Published: August 2022

Artykuł ma charakter osobistych wspomnień autorki o jej ojcu, doktorze Tadeuszu Kamzie (1921-1982), poznańskim urologu.
Neuroprotective Effects of a Novel Demeclocycline Derivative Lacking Antibiotic Activity: From a Hit to a Promising Lead Compound
Authors: Tomas-Grau Rodrigo , González-Lizarraga Florencia , Ploper Diego , Avila César Luis , Socías Sergio Benjamin , Besnault Pierre , Tourville Aurore , Mella Rosa M. , Villacé Lozano Patricia , Salado Clarisa , Rose Clémence , Séon-Méniel Blandine , Brunel Jean-Michel , Ferrié Laurent , Raisman-Vozari Rita , Michel Patrick P. , Figadère Bruno , Chehín Rosana
Published: August 2022

The antibiotic tetracycline demeclocycline (DMC) was recently reported to rescue α-synuclein (α-Syn) fibril-induced pathology. However, the antimicrobial activity of DMC precludes its po-tential use in long-term neuroprotective treatments. Here, we synthesized a DMC derivative with residual antibiotic activity and improved neuroprotective effects. The molecule, called de-rivative demeclocycline (DDMC), was obtained by the removal of both dimethylamino substitu-ents at position 4 and the reduction of the hydroxyl group at position 12a on ring A of DMC. The modifications strongly diminished its antibiotic activity against Gram-positive and Gram-negative bacteria. Moreover, this compound preserved the low toxicity of DMC in dopaminergic cell lines while improving its ability to interfere with α-Syn amyloid-like aggregation, showing the highest effectiveness of all tetracyclines tested. Likewise, DDMC demonstrated the ability to reduce seeding induced by the exogenous addition of α-Syn preformed fibrils (α-SynPFF ) in ex vitro models and in SH-SY5Y-α-Syn-tRFP cells. In addition, in the presence of DDMC, α-SynPFF were less inflammogenic, as they dampened the release of tumor necrosis factor α (TNF-α) and glutamate by microglial cells compared to control fibrils. Our results suggest that DDMC may be a promising drug candidate for hit-to-lead development and preclinical studies in PD and other synucleinopathies.
Greek Military Nursing Officers’ Leadership Style: Compassion Competence and Personal Level at Work
Authors: THOMAI KLIMENTIDOU , Sarafis Pavlos , APOSTOLAKIS IOANNIS , MALLIAROU MARIA
Published: August 2022

Abstract: The present study seeks to investigate MNOs leadership style and how it influences their compassion competence and their personal level of compassion at work. This is a cross-sectional study carried out from December 2019 to May 2020 using the method of convenience sampling. The study involved 235 MNOs serving in Greek Military Hospitals. A single questionnaire containing Compassion at Work index, Compassion competence scale, and Multifactor Leadership Questionnaire (MLQ-5X), and socio-demographic and professional data, was used for data collection. A total of 400 printed questionnaires were distributed with a response rate of 58.75%. Data analysis was performed using the statistical package SPSS 22.0. The research showed that the transformational and transactional leadership styles coexist in the Nursing Corps of the Armed Forces with an average value of 2.72(SD=0.70)-2.95(SD=0.54) points and 2.47(SD=0.69)-2.74(SD=0.63) points respectively, while the passive style represented a very small percentage with an average subscale value of 0.88(SD=0.61)-0.94(SD=0.63) points. It was also found that both actual compassion at work and compassion ability had improved with the increase of transformational or transactional leadership style characteristics and amelioration of leadership outcome criteria. On the other side, a deterioration of these was observed with the increase of the passive leadership. Specifically, a higher score in the «Intellectual Stimulation» scale was associated with a higher level of compassion at work in the dimension «Experiencing the suffering of others» (p=0.010/SD=0.14), while higher values on the «Laissez-Faire Leadership» scale were associated with less compassion at work in the same dimension (p<0.001/SD=0.13). Also, a higher score on the «Contingent Reward» scale was associated with more compassion at work in the dimension «Takes appropriate action» (p=0.023/SD=0.16). Furthermore, higher values observed in the «Inspirational Motivation», «Individual Consideration» and «Extra Effort» scales were associated with a better communication ability (p=0.035/SD=0.09, p=0.022/SD=0.12, and p=0.042/SD=0.08 accordingly). Finally, a higher score on the «Effectiveness» scale was associated with higher sensitivity (p=0.049/SD=0.08). Teaching appropriate leadership behavior, promoting a culture of compassion, and continuing to train nurses to manage their emotions should be included in the infrastructure of nursing science.
Determining The Location of Land Subsidence Observation Points Based on Lithological Data and Land Cover Changes in Lampung Province
Authors: Perdana Redho Surya , Fikri Muhammad , Alif Satrio Muhammad , Isnaini Een Lujainatul , Fauzi Adam Irwansyah
Published: August 2022

Land subsidence is a phenomenon that always occurs due to natural factors as well as human actions. Land subsidence has an even impact on all fronts. Land subsidence occurs continuously, therefore it is necessary to observe the phenomenon of land subsidence periodically using the GNSS method, which requires a benchmark that serves as a reference point for observation. With the need for a new benchmark devoted to observing land subsidence, it is necessary to do spatial modeling which is useful for finding out the suitability of the location where the subsidence observation point will be made. Spatial modeling was carried out using land cover data and lithology type to then be given weight and score and determined the soil movement vulnerability class into three, namely low class, medium class, and high class. The results of the spatial modeling of subsidence vulnerability show that the area12292.60 square kilometers is low grade, 20230.64 square kilometers represents medium class and 540.32 square kilometers is high class. Based on these results, the planning of the location of new observation points was carried out in areas with moderate to high levels of vulnerability with a total of 87 points scattered throughout the cities in Lampung.
Implementation Analysis Disaster Prepared School in Elementary School
Authors: Bramasta Dhi , Andriani Ana
Published: August 2022

The analysis of the implementation of the disaster preparedness school aims to determine the implementation of the standby school and to find out the factors that encourage the realization of the disaster preparedness school at SDN 1 Pagerandong. Data collection with interviews, observations and documentation in order to collect data on the implementation of disaster preparedness schools and the factors that encourage the realization of disaster prepared schools. Data reduction, data presentation, drawing conclusions are the analysis in this study and supported by a regional approach to determine the condition of the research area. The results showed that the implementation of disaster preparedness schools was carried out through the integration of disaster knowledge in the school curriculum, socialization and collaboration with the community and the Regional Disaster Management Agency. The school building was built right above the ravine, where the position of the ravine was right next to the school building wall. Supported by the condition of the area with hilly morphology, so it is easy to experience soil movement and landslides occur. This condition is a factor in the realization of a disaster preparedness school at Pagerandong State 1 Elementary School.
Development of Geography Learning Tools Based on The Indonesian National Qualification Framework (KKNI) Curriculum
Authors: Hidayaht Achmad Nur , Budiaman Budiaman , Kurniawan Nandi
Published: August 2022

The development of learning tools is one of the efforts to improve the quality of education as an effort to provide complete and systematic learning tools. One of them is the development of learning tools including (RPS) Semester Learning Plans and (RTM) Student Assignment Designs according to the KKNI in introductory geography courses. The development of learning tools in this study used the ADDIE (Analysis, Design, Development or Production, Implementation or Delivery, and Evaluations) model, with data collection instruments through questionnaires and validation sheets with descriptive analysis techniques. The results of the needs analysis showed that 74.4% needed an RPS adjustment and 78.9% needed the development of teaching materials in a social study program (PIPS), while the evaluation of the development validity (RPS) of Semester Learning obtained an average score of 3.59 while for the average instrument assessment (RTM) the Student Assignment Plan was obtained. the mean score is 3.75 with a mean value of 3.67 with valid criteria. These results indicate that the development of learning tools is following the KKNI and is ready to be implemented in learning activities.
Test Of Critical Thinking Ability Assembly Assessment Prototype
Authors: Juita Erna , Dasrizal Dasrizal , Zuriyani Elvi
Published: August 2022

The purpose of this study is to develop and implement and produce valid and practical assessment tools for critical thinking skills in disaster geography learning. Assessment tools are said to be valid if they have been declared appropriate to be used to measure the process and learning outcomes of disaster geography by geography education experts and education evaluation experts. In the research design this development follows the development model according to plomp which consists of three phases. In this study only took the prototyping phase (prototype phase). The instrument used in this study is an assessment that has been designed beforehand in the form of selfassessment assessment, assessment of colleagues and critical thinking assessment. After the device was made, three trials were conducted which consisted of one-on-one (individual) trials, small group trials, and large group trials. The results obtained in this study are limited to the results of trials in small groups by evaluating previously designed assessments
Knowledge and Power: Courtly Science and Political Utility in the Work of Roger Bacon
Authors: Truitt Elly
Published: August 2022

In his major works for the pope, as well as several other works from his maturity, Bacon focused on the utility of natural knowledge, both in terms of human know-how and what that know-how could produce. He looked to the courtly sciences (such as medicine, astral science, optics, and material science), which privilege application and knowledge gained through the sensorium, as sources of natural knowledge and as exemplars for the potential of natural knowledge. This essay argues that Roger Bacon’s work ought to be understood within the context of the court. Bacon’s emphasis on devices in the pursuit of knowledge and utility demonstrates the extent to which the courtly sciences (such as engineering, navigation, alchemy, and divination) were valued alongside traditional natural philosophical frameworks, and need to be understood in that context. Both the courtly sciences and Bacon’s theory of scientia experimentalis focus on materials, sensory knowledge, and knowledge of particulars in pursuit of applied ends. Bacon drew inspiration from the courtly sciences in theorizing how natural knowledge could serve ruling power. By examining Bacon’s major works on scientia experimentalis and analyzing his reliance on examples from the history of Alexander the Great, this essay demonstrates the interrelation of political power and erudite knowledge, and how they intersected through the cultivation and application of experimentum and technology. Finally, Bacon’s interest in the utility of knowledge suggests that courtly settings in this period are significant locations for the development and applications of natural knowledge.
Multidemensional Scaling Benih Lada Bersertifikat di Provinsi Kalimantan Barat
Authors: Gorda Aprillia , Dolorosa Eva , Radian NFN
Published: August 2022

West Kalimantan Province is one of Indonesia's seven largest pepper-producing provinces and was solicited to be a pioneer and advocate of the national pepper development program. This study aimed to analyze the sustainability status of certified pepper seedlings in West Kalimantan. The sustainability of the seeds system was analyzed using the multidimensional scaling (MDS) method in four districts with seed orchard and pepper seedlings producers: Bengkayang District, Sambas District, Sanggau District, and Sintang District. The research stages were an analysis of the sustainability status based on the dimensions of ecology, economy, socio-culture, technology, and infrastructure, as well as legal and institutional, followed by an MDS analysis of 50 attributes related to the sustainability index scale based on values ranging from 0–100. The ecological, socio-cultural, technological, and infrastructural dimensions were quite sustainable in the certified pepper seedlings supply system, while the economic, legal, and institutional dimensions were less sustainable. 34 out of 50 attributes were influential and sensitive to the sustainability status of certified pepper seedlings. The dominant attributes were drought/dry season (ecology), low awareness of farmers in using certified seeds (social-culture) related to low demand for certified pepper seedlings (economy), production planning and seed distribution (technology and infrastructure), and the necessity to cooperate with a research institution and seed orchard (legal and institutional). Therefore, special efforts were required from the local government to increase the pepper seedlings' availability and provide information on good pepper cultivation management to farmers and pepper seedlings managers.
Attosecond Optical Switching
Authors: Hassan Mohammed , Hui Dandan , Alqattan Husain , Zhang Simin , Pervak Vladimir , Chowdhury Enam
Published: August 2022

Modern electronics are founded on switching the electric signal by radio frequency (RF) electromagnetic fields on the nanosecond timescale, limiting the information processing to the gigahertz speed. Recently, optical switches have been demonstrated using terahertz and ultrafast laser pulses to control the electric signal and enhance the switching speed to the picosecond and a few hundred femtoseconds time scale. Here, we exploit the reflectivity modulation of the fused silica dielectric system in a strong light field to demonstrate the optical switching (ON/OFF) with attosecond time resolution. Moreover, we present the capability of controlling the optical switching signal with complex synthesized fields of ultrashort laser pulses for data binary encoding. This work paves the way for establishing optical switches and light-based electronics with petahertz speeds, several orders of magnitude faster than the current semiconductor-based electronics, opening a new realm in information technology, optical communications, and photonic processor technologies.
A Shift Toward Activated Receptors and Enhanced Effector Functions on NK Cells Contribute to Immune Imbalance During Sepsis
Authors: He Wanxue , Zhang Lin , Luo Zhiming , Xu Jianqiao , Guan Wei , Xie Lixin
Published: August 2022

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to an infection. It is a disease with a high incidence and mortality rate, which has a tremendous impact on global health and social economy. Remarkably, immune imbalance has been recognized as a key pathophysiological change in sepsis, and NK cells, one of the most important innate immune cells, are involved in this process and play a crucial role in it. However, the role of NK cells in the pathogenesis of sepsis is still controversial and there remains a gap in understanding the exactly immune responses of NK cells to sepsis and even infections secondary to sepsis. In this study, we used sepsis mouse models to investigate the alterations of NK cells, and then we subjected the septic mice to a secondary influenza A virus (H1N1) infection to characterize the anti-infection immune responses of NK cells. Here, we demonstrated that NK cells presented an activated phenotype in early phase of sepsis as illustrated by increased activated CD69 and NKG2D and reduced inhibitory KLRG1 expression on NK cells. Moreover, we observed that NK cells were excessive overall activated in the sepsis mouse model subjected to secondary infections as illustrated by cell surface receptor expression profiles, increased IFN-γ and CD107a expression after stimulation, aggravated lung inflammation and pathological injury, and increased systemic inflammation cytokines, which might be an important reason for higher mortality in PR8-infected sepsis mice. In summary, NK cells exhibit excessive activated phenotype induced by sepsis, contributing to unrestrained systemic inflammation, pathogenesis of tissue damage, physiological dysfunction, and increased mortality.
An improved blind Gaussian source separation approach based on generalized Jaccard similarity
Authors: Fu Xudan , Ye Jimin , E Jianwei
Published: August 2022

Blind source separation (BSS) consists of recovering the independent sourcesignals from their linear mixtures with unknown mixing channel. The existing BSS approaches rely on the fundamental assumption: the source signals are non-Gaussian, this limited the use of BSS seriously. To overcome this problem and the weakness of cosine index in measuring the dynamic similarity of signals, this study proposes the fuzzy statistical behavior of local extremum (FSBLE) based on generalized Jaccard similarity as the measure of signal’s similarity to implement the separation of source signals. In particular, the imperialist competition algorithm is introduced to minimize the cost function which jointly considers the stationarity factor describing the dynamical similarity of each source signal separately and the independency factor describing the dynamical similarity between source signals. Simulation experiments on synthetic nonlinear chaotic Gaussian data and ECG signals verify the effectiveness of the improved BSS approach and the relatively small cross-talking error and root mean square error(RMSE) indicate that the approach improves the accuracy of signal separation.
Pain adverse events, Bell’s palsy, and Guillain-Barré syndrome Following Vaccination
Authors: Ricke Darrell O.
Published: August 2022

Objective
Some individuals (vaccinees) experience pain related adverse events following vaccinations. The majority of these pain related vaccination reactogenicity adverse events resolve within days. Rare adverse events like Bell’s palsy and Guillain-Barré syndrome (GBS) have been associated with some vaccines. Herein, multiple working hypotheses are examined in the context of available characteristics of vaccinees and onset of these pain related adverse events post vaccination.
Methods
The Vaccine Adverse Event Reporting System (VAERS) database was datamined for pain associated vaccine adverse events data by vaccine, age, gender, dose, and onset post vaccination. Results for vaccines with the highest number of pain related adverse events were compared.
Results
For the pain related adverse events examined, the highest number of adverse events are reported within 1 day, roughly half this number the second day, and roughly a quarter this number by the third day. The day of onset for these pain related adverse events approximates a power of two decay pattern for the first three days. This same pattern is observed for all of the vaccines with the highest number of pain related adverse events. The consistency of these day of onset frequency patterns of examined adverse events following vaccinations for multiple unrelated vaccines enables the exclusion of specific vaccine components and excipients as specifically causative entities.
Conclusion
The observed onset occurrences of examined pain associated adverse events are consistent with likely etiology relationship with innate immune responses to vaccinations for multiple vaccines including SARS-CoV-2 COVID-19, influenza, and additional vaccines. Innate immune responses may be contributing to the initial etiology of Bell’s palsy and GBS post SARS-CoV-2 mRNA and adenoviral vaccinations.