bluuebunny/crossref_metadata_2025 huggingface dataset:
Social inequalities in the incidence, mortality, and survival of neoplasms in women from a municipality in Southeastern Brazil
Authors: Ferreira Maria do Carmo , Sarti Flávia Mori , Barros Marilisa Berti de Azevedo
Published: February 2022

This study aims to analyze inequalities in the incidence, mortality, and survival of the main types of cancer in women according to the Social Vulnerability Index (SVI). The study was conducted in Campinas, São Paulo State, Brazil, from 2010 to 2014, and used data from the Population-based Cancer Registry and the Mortality Information System. Incidence and mortality rates standardized by age and 5-year survival estimates were calculated according to the social vulnerability strata (SVS), based on the São Paulo Social Vulnerability Index. Three SVS were delimited, with SVS1 being the lowest level of vulnerability and SVS3 being the highest. Rate ratios and the concentration index were calculated. The significance level was 5%. Women in SVS1 had a higher risk of breast cancer (0.46; 95%CI: 0.41; 0.51), colorectal cancer (0.56; 95%CI: 0.47; 0.68), and thyroid cancer (0.32; 95%CI: 0.26; 0.40), whereas women from SVS3 had a higher risk of cervical cancer (2.32; 95%CI: 1.63; 3.29). Women from SVS1 had higher mortality rates for breast (0.69; 95%CI: 0.53; 0.88) and colorectal cancer (0.69; 95%CI: 0.59; 0.80) and women from SVS3 had higher rates for cervical (2.35; 95%CI: 1.57; 3.52) and stomach cancer (1.43; 95%CI: 1.06; 1.91). Women of highest social vulnerability had lower survival rates for all types of cancer. The observed inequalities differed according to the location of the cancer and the analyzed indicator. Inequalities between incidence, mortality, and survival tend to revert and the latter is always unfavorable to the segment of highest vulnerability, indicating the existence of inequality in access to early diagnosis and timely treatment.
Implantação do protocolo de vigilância do óbito com menção de tuberculose e seus efeitos na vigilância de um município brasileiro de grande porte
Authors: Cordeiro Dinah Carvalho , Gonçalves Maria Jacirema Ferreira
Published: February 2022

O objetivo deste estudo foi avaliar o grau de implantação e de impacto do protocolo de vigilância do óbito por tuberculose (TB) em um município de grande porte e com elevada carga de TB. Para esta pesquisa avaliativa, elaborou-se um modelo lógico e matriz de julgamento. Os dados primários foram coletados a partir de um questionário aplicado aos profissionais e os dados secundários foram obtidos na Secretaria Municipal de Saúde de Manaus, Amazonas, Brasil. O impacto da adoção do protocolo foi analisado pelos indicadores de resultados e a evolução das taxas de incidência e mortalidade por TB, a partir da regressão linear simples e variação percentual. O grau de implantação da vigilância do óbito com menção de TB identificado foi parcial (51%). Quanto à evolução dos indicadores de incidência e mortalidade por TB, observou-se tendência significativa de aumento da taxa da incidência de TB no período de 2006 a 2019. A mortalidade por TB e a proporção dos óbitos com confirmação laboratorial para TB apresentaram incremento após a implantação do protocolo, indicando aumento da vigilância. A implantação parcial da vigilância do óbito de TB indica necessidades de mudanças no processo de trabalho da equipe que gerencia o Sistema de Informações sobre Mortalidade e o Programa de Controle da TB municipal. As mudanças observadas demonstram mais qualificação das informações do óbito por TB, assim como a vigilância no diagnóstico da TB contribuiu para a definição de casos com confirmação laboratorial para TB.
Online teaching modality in a pandemic time: the opinion from a group of undergraduate physics students
Authors: de Melo Gabriel Lisboa , Brazaca Laís Canniatti , Silva Luciano Fernandes
Published: February 2022

The pandemic of SARS-CoV-2 affected educational activities around the world. In this scenario, online teaching was the main strategy adopted by Brazilian universities. The literature presents possibilities and boundaries to physics teaching on distance learning modality. In this context, this article aimed to investigate the opinion from a group of physics undergraduate students to have an overview of challenges for Brazilian universities. This group had the face-to-face classes changed abruptly to online modality. An electronic quiz was conducted to analyse data based on Content Analysis procedures. The group believes in the potential of online teaching during the pandemic time, but agrees that several aspects need to change. The students report that they have faced problems related to technical, pedagogical, and socioeconomic aspects. As consequence of distance learning modality, students have presented symptoms of anxiety, depression, and lack of motivation. The group points out professor training as a focus that might help improve online teaching.
Seed vigor in performance of wheat plants: evidence of interaction with nitrogen
Authors: Bagateli José Ricardo , Bortolin Gabriel Streck , Bagateli Ricardo Mari , Franco Jader Job , Villela Francisco Amaral , Meneghello Geri Eduardo
Published: February 2022

Abstract: The use of high-quality seeds is an important factor in the crop production system. Its benefits to the performance of plants and possible interactions with other factors - such as nitrogen fertilization - could be better understood from a multivariate analysis perspective. With this approach, the objective of this work was to evaluate the impacts of wheat seed vigor and possible interactions with nitrogen fertilization on the performance of wheat plants. The data analyzed were obtained from the average results gathered through three experimental environments, located in the department of Alto Paraná, Paraguay. High-vigor seeds with provided a better plant stand and also a greater growth in the formed tillers stage. This category also provided plants with higher performance - a condition found for dry matter weight - in the booting, flowering and milk seed stages, in the presence and absence of nitrogen fertilization. The multivariate analysis showed that plants originating from high-vigor seeds that had not been fertilized with N showed a similar performance to that of low-vigor plants, but fertilized with N. High-vigor wheat seeds provide plants with superior performance.
Adjustment of the electrical conductivity test to evaluate the seed vigor of chickpea (Cicer arietinum L.)
Authors: Araújo Joyce de Oliveira , Dias Denise Cunha Fernandes dos Santos , Miranda Rafaela Marques de , Nascimento Warley Marcos
Published: February 2022

Abstract: The definition of methodologies that allow evaluating the physiological potential of chickpea seeds is important to ensure the commercialization of lots with high performance. Thus, this research aimed to determine the most suitable conditions for conducting the electrical conductivity test in chickpea seeds to classify lots according to vigor level. Therefore, seeds from five lots of cultivar BRS Aleppo and four lots of cultivar Cícero were subjected to tests to characterize their initial quality and the results were compared with those obtained in the electrical conductivity test. To assess electrical conductivity, five soaking periods (2, 4, 8, 12, and 24 hours) were combined with four volumes of water (75, 100, 150, and 250 mL) at 25 °C temperature. The results show that the electrical conductivity test is efficient in evaluating the physiological potential of chickpea seeds, providing information equivalent to other vigor tests. For the electrical conductivity test, it is recommended to use 50 seeds soaked in 150 mL of water, for 24 h, at 25 °C.
Association of Clonal Hematopoiesis of Indeterminate Potential with Worse Kidney Function and Anemia in Two Cohorts of Patients with Advanced Chronic Kidney Disease
Authors: Vlasschaert Caitlyn , McNaughton Amy J.M. , Chong Michael , Cook Elina K. , Hopman Wilma , Kestenbaum Bryan , Robinson-Cohen Cassianne , Garland Jocelyn , Moran Sarah M. , Paré Guillaume , Clase Catherine M. , Tang Mila , Levin Adeera , Holden Rachel , Rauh Michael J. , Lanktree Matthew B.
Published: February 2022

Significance Statement

Clonal hematopoiesis of indeterminate potential (CHIP), a premalignant expansion of clonal leukocytes caused by acquired somatic mutations in myeloid stem/progenitor cells, occurs in 10%–15% of the general population aged 65 years or older. This proinflammatory condition appears causally associated with cardiovascular disease and death. The authors found that 43 of 172 (25%) individuals with advanced CKD had CHIP. Those with CHIP had a 2.2-fold greater risk of kidney failure over 5 years of follow-up and were more likely to have complications of CKD (including anemia) compared with those without CHIP. More research, including studies in animal models, is needed to understand the relationship between CHIP and CKD. CHIP-related inflammation might offer a novel therapeutic target for those with CHIP and CKD.

Background

Clonal hematopoiesis of indeterminate potential (CHIP) is an inflammatory premalignant disorder resulting from acquired genetic mutations in hematopoietic stem cells. This condition is common in aging populations and associated with cardiovascular morbidity and overall mortality, but its role in CKD is unknown.

Methods

We performed targeted sequencing to detect CHIP mutations in two independent cohorts of 87 and 85 adults with an eGFR<60 ml/min per 1.73m2. We also assessed kidney function, hematologic, and mineral bone disease parameters cross-sectionally at baseline, and collected creatinine measurements over the following 5-year period.

Results

At baseline, CHIP was detected in 18 of 87 (21%) and 25 of 85 (29%) cohort participants. Participants with CHIP were at higher risk of kidney failure, as predicted by the Kidney Failure Risk Equation (KFRE), compared with those without CHIP. Individuals with CHIP manifested a 2.2-fold increased risk of a 50% decline in eGFR or ESKD over 5 years of follow-up (hazard ratio 2.2; 95% confidence interval, 1.2 to 3.8) in a Cox proportional hazard model adjusted for age, sex, and baseline eGFR. The addition of CHIP to 2-year and 5-year calibrated KFRE risk models improved ESKD predictions. Those with CHIP also had lower hemoglobin, higher ferritin, and higher red blood cell mean corpuscular volume versus those without CHIP.

Conclusions

In this exploratory analysis of individuals with preexisting CKD, CHIP was associated with higher baseline KFRE scores, greater progression of CKD, and anemia. Further research is needed to define the nature of the relationship between CHIP and kidney disease progression.
Psychische Gefährdungsbeurteilung im Einzelhandel
Authors: Heine Stephanie , Kindel Jutta
Published: February 2022

Zur Vermeidung und Reduktion psychischer Beeinträchtigungen ist es unabdingbar, dass potenzielle Belastungen am Arbeitsplatz frühzeitig erkannt und behoben werden. Mit „PegA“ der Berufsgenossenschaft Handel und Warenlogistik (BGHW) steht für den Groß- und Einzelhandel ein komplettes Programm der Analyse psychischer Belastung und anschließender Gestaltung gesunder Arbeit zur Verfügung. Positive Erfahrungen mit den Analysebausteinen wurden in einem Einzelhandelsunternehmen in Hamburg gemacht.
A Révay család könyvtárának feltárt kötetei az Esztergomi Főszékesegyházi Könyvtárban
Authors: Dobó Judit
Published: February 2022

A Révay család több tagja is az esztergomi székeskáptalan javadalmasa volt, így az Esztergomi Főszékesegyházi Könyvtárban jelentős azoknak a könyveknek a száma, amelyek a Révayakhoz köthetők. Az ő köteteiken kívül a család nem egyházi pozícióban lévő tagjaitól is több kötetet őriz a gyűjtemény. A jelenlegi közlemény a 16–17. században élt családtagok újonnan azonosított köteteit írja le, hivatkozva a korszak már korábban ismertetett könyveire. A család könyvtárát, a gyűjtemény bizonyos darabjainak jelenlegi helyét ismeri a szakirodalom. Az eddig ismert kötetek igen alacsony száma viszont megnehezíti egyes kérdések megválaszolását. A Révay Ferenc (?–1670) turóci főispán szklabinyai könyvtáráról készült 1651-es könyvjegyzék ugyan rendelkezésünkre áll, de a rövid, pontatlan leírások nem segítik a művek azonosítását. Így a könyvtár összetételéről, illetve arról, hogy mely családtagok köteteit tartalmazhatjamég a jegyzék, nem kapunk pontos képet. Az Esztergomi Főszékesegyházi Könyvtár gyűjteményében folyó katalogizálási munka során az utóbbi időben számos olyan kötet került feldolgozásra, melyeket eddig nem ismert a szakirodalom. A példányok jelentős részét sikerült azonosítani az 1651-es könyvjegyzék tételeivel, így ezek a kötetek segítséget nyújthatnak olyan kérdések megválaszolásában, pontosításában, amelyekre eddig nem volt lehetőség, ugyanakkor számos új problémát is felvetnek.
ПРАВОВЫЕ АСПЕКТЫ МЕХАНИЗМА ОБЕСПЕЧЕНИЯ БАЛАНСА ЧАСТНЫХ, ГРУППОВЫХ И ОБЩИХ ИНТЕРЕСОВ В ПРАВОВОМ РЕГУЛИРОВАНИИ ГЕНОМНЫХ ИССЛЕДОВАНИЙ
Authors:   Московский государственный юридический университет имени О.Е. Кутафина, Кубышкин Алексей Викторович
Published: February 2022

Статья посвящена анализу такого принципа правового регулирования в сфере геномных исследований, как баланс интересов. Определяются три основных уровня интересов. Исследуются основные факторы, учитываемые при обеспечении баланса интересов, высказываются предложения по формированию правового регулирования. Определяются основные элементы механизма обеспечения баланса интересов, высказывается предположение о необходимости использования симбиотического регулятора, сочетающего в себе как правовые нормы, так и нормы иной социальной природы.
ОСОБЕННОСТИ ПРАВОВОГО РЕГУЛИРОВАНИЯ В СФЕРЕ ПЕРЕВОЗКИ БИОГРУЗОВ
Authors:   Самарский университет, Рузанова Валентина Дмитриевна , Крюкова Елена Сергеевна ,   Самарский университет
Published: February 2022

В статье анализируется гражданское законодательство в аспекте возможности применения конструкции договора перевозки грузов к транспортировке биологических материалов, поднимаются проблемы унификации используемого законодателем в этой части понятийного аппарата, подчеркивается необходимость выработки специальных норм, отражающих специфику транспортировки биогрузов, предлагается корректировка ряда легальных положений с учетом особенностей объекта перевозки.
БАЗЫ ДАННЫХ ДНК-ПРОФИЛЕЙ В УГОЛОВНОМ СУДОПРОИЗВОДСТВЕ: УСТАНОВЛЕНИЕ ИСТИНЫ И / ИЛИ ПРЕЗУМПЦИЯ НЕВИНОВНОСТИ?
Authors:   Томский государственный университет, Андреева Ольга Ивановна , Трубникова Татьяна Владимировна ,   Томский государственный университет
Published: February 2022

В статье исследуется влияние презумпции невиновности (в широком ее понимании) на правила создания и ведения баз ДНК-профилей, систематизируются направления такого влияния и их последствия для уголовного судопроизводства, формулируются предложения, направленные на обеспечение прав лиц в уголовном процессе.
ПРЕЗУМПЦИЯ СОГЛАСИЯ НА ПОСМЕРТНОЕ ДОНОРСТВО В КОНТЕКСТЕ ПРАВА НА ЛИЧНУЮ НЕПРИКОСНОВЕННОСТЬ ГРАЖДАНИНА
Authors:   Томский государственный университет, Гончарова Валерия Андреевна ,   Томский государственный университет систем управления и радиоэлектроники
Published: February 2022

Настоящая статья посвящена анализу норм отечественного законодательства, устанавливающих презумпцию согласия на посмертное изъятие органов и тканей, с позиции их соответствия устанавливаемому Конституции РФ и ГК РФ праву на личную неприкосновенность гражданина (ст. 23 Конституции РФ, ст. 150 ГК РФ). Анализируется проект ФЗ «О донорстве органов человека и их трансплантации», дается его положительная оценка.
Reconstrucción de la vegetación asociada al depósito tobáceo fluvial holoceno del Nogal de El Batán, Las Parras del Martín, Cordillera Ibérica
Authors: Aranbarri Josu , Sancho Marcén Carlos , Arenas Abad Concepción , Bartolomé Miguel , Leunda María , Rico María Teresa , González Sampériz Penélope
Published: February 2022

El desarrollo de edificios tobáceos de origen fluvial se asocia a menudo con fases cálidas y húmedas cuaternarias y son comúnmente empleados como indicadores climáticos. En el presente trabajo se estudia el depósito tobáceo fluvial Holoceno del Nogal de El Batán, situado en el valle del río Las Parras (Cordillera Ibérica, NE España), bajo una perspectiva cronológica, estratigráfica y palinológica. La acumulación tobácea de 8,2 m de espesor, intercala gravas, facies de rudstones de fitoclastos, boundstones de tallos, limos y arenas de composición carbonatada, además de margas, lime mud y niveles turbosos. La acumulación tobácea se emplaza en el Holoceno temprano final (ca. 8400 cal BP) y se correlaciona con los cambios ambientales ocurridos en la región, identificando tres fases principales. Los análisis polínicos señalan un paisaje dominado por coníferas en la base de la secuencia, esencialmente Pinus nigra/sylvestris tipo y Juniperus, mientras que localmente se desarrolla un bosque ripario donde destacan Corylus, Alnus, Salix, Populus, Celtis, Fraxinus, Tamarix y Rosaceae. En el Holoceno medio (ca. 8000-5000 cal BP) se produce la máxima expansión de las quercíneas, junto con taxones termófilos como Pistacia, Rhamnus, Arbutus y Olea. El incremento de taxones herbáceos y ruderales, y en especial la aparición de esporas coprófilas, marca la expansión agro-pastoril a lo largo del valle fluvial durante el Holoceno tardío (ca. 4300 cal BP).
Detección de contaminantes mediante una red inalámbrica de sensores y reconocimiento de patrones
Authors: Arroyo Patricia , Lozano Jesús , Suárez José Ignacio , Herrero José Luis , Carmona Pablo
Published: February 2022

En este trabajo se presenta una red de sensores inalámbrica de bajo consumo y bajo coste para la detección de compuestos contaminantes disueltos en agua. Esta red está compuesta por nodos con varios sensores de gases encargados de recibir la información y de forma inalámbrica, a través del protocolo ZigBee, enviarla a una puerta de enlace conectada a Internet. Una nube de datos se utiliza para almacenar los datos de cada nodo y realizar el pre-procesamiento de los mismos. Para la realización del análisis o procesado de los datos obtenidos, se ha realizado una reducción de la dimensionalidad mediante análisis de componentes principales (PCA) y una clasificación mediante redes neuronales artificiales (RNA) de las clases previamente aprendidas.
SIAR: an autonomous ground robot for sewer inspection
Authors: Alejo David , Marques Carlos , Caballero Fernando , Alvito Paulo , Merino Luis
Published: February 2022

This paper summarizes the latest advances of the EU Project SIAR-ECHORD++, whose main objective is the design of a new robotic platform for inspecting visitable sewers. The SIAR robot aims to determine the sewer serviceability, to identify critical structural defects, to perform sewer monitoring and eventually to take water or gas samples of the environment. To this end, an autonomous IP67 ground robot equipped with RGB-D sensors and with a powerful wireless communication system is being developed. It is able to perform 3D structure reconstruction in real-time that could be used to detect defects in the sewer structures. This paper presents the key aspects in the design of the platform as well as preliminary experimental results in real sewer systems.
MANUAL PARA A OBTENÇÃO E APLICAÇÃO DE VARIAVEIS HIDROMETEOROLÓGICAS A PARTIR DE BASES DE DADOS GLOBAIS PARA A GESTÃO DAS SECAS
Authors: Araneda Cabrera Ronnie Javier , Puertas Agudo Jerónimo , Alvarez Enjo Manuel Ali , Penas López Víctor
Published: February 2022

Este manual pretende ser uma ferramenta introdutória básica para a gestão da seca. Este fenômeno hidrológico extremo é um dos mais importantes na gestão dos recursos hídricos, pois causam anualmente imensas perdas econômicas e ecológicas em todo o mundo que condicionam a segurança alimentar e a qualidade de vida das pessoas.
La prestación de servicios de agua y saneamiento asequibles para las personas en condición de pobreza y vulnerabilidad: la garantía de un suministro mínimo vital
Authors: Rivero María del Mar , Luis Romero Elena de , Ulloa Luis Fernando
Published: February 2022

Este documento pone el foco de atención en ejemplos prácticos de cómo algunos gobiernos de la región de America Latina y el Caribe buscan garantizar la asequibilidad de los servicios de agua y saneamiento a los usuarios, mediante subsidios representados en tarifas diferenciadas y programas sociales específicos, haciendo énfasis en la protección de las personas y colectivos en situación de pobreza y vulnerabilidad. En todos estos ejemplos, la puesta en marcha de estas medidas ha requerido de la colaboración activa de los prestadores de servicios. A partir de información secundaria fueron seleccionados y estudiados casos, a nivel nacional y municipal, en 4 países, Chile, Colombia, Ecuador y Uruguay, cuyas particularidades son abordadas en este documento con el objetivo de presentar criterios que permitan orientar la implementación de políticas públicas y programas con este propósito.
Convivir con el coronavirus: ¿Cómo aprovechar la inercia para digitalizar a las pymes de la región?
Authors: Suaznabar Claudia , Herrera Diego , Cathles Alison
Published: February 2022

Las medidas de confinamiento y distanciamiento social provocadas por la pandemia de la COVID llevaron a la adopción en la región de las tecnologías digitales, inclusive entre las pymes que antes de la pandemia habían exhibido grandes rezagos. ¿Será posible seguir o, incluso, acelerar este nuevo ritmo de adopción digital entre estas empresas para cerrar las brechas de adopción tecnológica y mejorar su desempeño económico? Esta nueva entrega de la serie “Convivir con el coronavirus” responde a esta pregunta con datos que muestran la digitalización de las pequeñas empresas en la región, así como reflexiones y aprendizajes sobre cómo profundizarla.
ADDIEM – Um Processo para Criação de Cursos MOOC
Authors: Battestin Vanessa , Santos Pollyanna
Published: February 2022

Esse artigo apresenta a proposta de um processo de criação de cursos MOOC, batizado como ADDIEM, que foi concebido a partir do modelo ADDIE e customizado para as especificidades dos MOOC e concepções de uma instituição pública. Para cada etapa do processo foram definidos seus objetivos e artefatos gerados, bem como foram criados os modelos de documentos que servem de suporte. O processo e seus modelos de documentos foram avaliados por uma comissão e por profissionais da área de ensino. Após ajustes o ADDIEM foi, então, validado e, posteriormente, avaliado por professores que o utilizaram para elaboração de cursos. Resultados apontam que o modelo foi bem aceito e que efetivamente apoia os professores no processo de construção. Apesar de concebido no contexto de uma instituição, pode ser utilizado ou adaptado para outras.
Palavras-chave: MOOC. ADDIEM. Modelo para criação de cursos.
Whey Fortified Ready-to-Reconstitute Elephant Apple (Dillenia Indica) Juice Powder: Methodical Optimization, Micro-Structural and in Vitro Digestion Analyses
Authors: Borah Udangshree , Boruah Rimki , Islam Sahijul , Borah Abhijit , Saikia Ananta , Boro Robin , Saikia Hemanta , Mutnuri Srikanth , Ganguly Anasuya , Baishya Rinku , Saikia Lakshi , Purkayastha Manashi Das
Published: February 2022

Elephant apple fruit, though bestowed with multifarious medicinal properties and available in many Asian countries, has no known commercial processed product due to its tough fibrous calyces, highly astringent juice and brown discolouration. In this study, the juice was blended with concentrated whey in different proportions (v/v) for assessing organoleptic acceptability. Principal Component Analysis of the sensory scores and subsequent evaluation of blends’ antioxidant activity revealed the superiority of 1:1 (v/v) admixture over other counterparts. Further, study focussed on optimization of process variables (maltodextrin concentration and inlet temperature of spray dryer) for recuperating beverage powder from the juice-whey blend (1:1 v/v). Developed powders presented different surface morphologies (wrinkled/shrunk/ellipsoidal/fused particles having 2-30 µm diameters), and were organoleptically favourable with good yield (63.33-88.33%), dispersibility (33.40-56.57%), moderate antioxidative potential (37.45-54.57%), improved sugar, protein and whiteness index. In-vitro digestion release of protein and antioxidant activity from the optimized powder showed increasing trend with time, unlike those of fresh juice and juice-whey blend (1:1 v/v). Thus, ready-to-reconstitute juice powder(s) with appreciable features was developed from an underutilized fruit using methodical statistical approaches, and the resultant product was found to provide protracted release of protein and antioxidants during simulated digestion.
Chronic Myeloid Leukemia in a Young Man with Unusual Presentation of Weight Loss, Bone Pain, and Abdominal Pain
Authors: Mohamadian Niloufar , Seyedmoradi Mehdi , Izadi Babak , Amirian Farhad , Ramezani Mazaher
Published: February 2022

Chronic myeloid leukemia (CML) is a clonal myeloproliferative neoplasm and one of the main subtypes of leukemia that mainly affects adults. The incidence of CML increases slowly with age until the middle of the fourth decade, and then it rises rapidly. Anemia, splenomegaly, and constitutional symptoms are the most common signs and symptoms at presentation. Here we report a 27-year-old man with bone pain and generalized abdominal pain. He also had weight loss because of anorexia and easy satiety. The qualitative probe-based real-time PCR (qRT-PCR) result was positive for BCR-ABL1 (t9:22) P210 mutation. The patient was treated with Imatinib, the standard first-line treatment for CML, and showed clinical improvement. His pain also decreased, and he was discharged in good condition.
Potential role of gut microbiota in patients with COVID-19, its relationship with lung axis, central nervous system (CNS) axis, and improvement with probiotic therapy
Authors: Alibeik Nazanin , Pishgar Elham , Bozorgmehr Ramin , Aghaaliakbari Farshad , Rahimian Neda
Published: February 2022

Coronavirus Disease 2019 (COVID-19) is a pandemic disease caused by a new corona virus. COVID-19 affects different people in different ways. COVID-19 could affect the gastrointestinal system via gut microbiota impairment. Gut microbiota could affect lung health through a relationship between gut and lung microbiota, which is named gut-lung axis. Gut microbi- ota impairment plays a role in pathogenesis of various pulmonary disease states, so GI diseases were found to be associated with respiratory diseases. Moreover, most infected people will develop mild to moderate gastrointestinal (GI) symptoms such as diarrhea, vomiting, and stomachache, which is caused by impairment in gut microbiota. Therefore, the current study aimed to review potential role of gut microbiota in patients with COVID-19, its relation with lung axis, Central Nervous System (CNS) axis and improvement with probiotic therapy. Also, this review can be a guide for potential role of gut microbiota in patients with COVID-19.
Molecular detection and characterization of dengue isolates circulating in north India
Authors: Mishra Manmohan , Yadav Santosh Kumar , Mishra Shravan Kumar , Ratho Radha Kanta
Published: February 2022

Background and Objectives: In recent decades, the incidence of dengue has increased dramatically. In dengue-endemic countries, changes in dengue virus serotypes, genotypes, and lineages have been reported. This study was designed to detect and characterize the dengue virus isolates circulating in North India by serological and molecular techniques.
Materials and Methods: This study was conducted at the Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. NS1 antigen and IgM antibody against dengue were detected by ELISA methods, viral RNA was extracted and amplified by conventional PCR and one-step single-tube multiplex PCR. The purified PCR products were cycle sequenced and a database search was implemented for the confirmation of the sequence product. Phylogenetic analysis was carried out with previously reported sequences.
Results: Among 1509 samples, 205 (13.6%) were found positive for IgM antibodies with the highest number (n=67) among the 21 to 30 years age group with peak positivity during post-monsoon months. Among acute samples, NS1 antigen was pos- itive in 62.9%. Seven patients out of 13 had dengue viral RNA in PCR. It comprised six DENV-2 serotypes and one DENV-3 serotype. On phylogenetic analysis, DENV-2 strains grouped with genotype IV and DENV-3 with genotype III.
Conclusion: Dengue infection was found frequently during post-monsoon season. The positivity rate of the dengue NS1 antigen test was greater than that of the antibody test. The dengue isolates were characterized as genotype IV and genotype III of DENV-2 and DENV-3 respectively.
Impact of Mulberry Leaf Extract and Mulberry Leaf Powder on Serum Nesfatin-1 Level in Nicotinamide/Streptozotocin-Induced Type 2 Diabetic Rats
Authors: Eskandari Mehrabadi M , Salemi Z , Fallah S
Published: February 2022

Background & Objective: In traditional medicine, leaves of white mulberry (Morus alba L.) are used as antidiabetic agents. Considering the presence of flavonoids, this plant exhibits insulin mimetic activities. Nesfatin-1 is described as an anorexigenic regulatory peptide, which can influence glucose metabolism via insulin sensitivity enhancement. This study examined the effects of both mulberry leaf powder and extract (MLP and MLE) on fasting blood glucose (FBG), nesfatin-1, and insulin in diabetic Wistar rats.
Materials & Methods: Five groups of rats (n, 40) were included and examined in this study. A group was selected as the healthy control (I), while the other groups received streptozotocin and nicotinamide (55 and 110 mg/kg bw, respectively) for diabetes induction. Diabetic rats were then grouped as follows: control group (II); sham group (receiving ethanol) (III); treatment group receiving 600 mg/kg/day of MLE (IV); and treatment group receiving 25% MLP (V). After 6 weeks, we measured insulin, nesfatin-1, and FBG in the groups. 
Results: The FBG level decreased in the treatment groups, while serum insulin increased in comparison with the diabetic controls. In addition, serum level of nesfatin-1 improved significantly (to an almost normal level) in MLP rats in comparison with the diabetic controls. (pvalue<0.05) The effects of MLE on serum nesfatin-1 was similar to MLP but not significant. (pvalue>0.05)
Conclusion: Considering the reduction in insulin level and the rise in blood glucose, the diabetic control group showed an increase in serum nesfatin-1 with a compensatory mechanism, while hyperglycemia improved in the MLE and MLP groups, and the level of nesfatin-1 reduced. MLP showed greater efficacy than MLE in the improvement of nesfatin-1, which might be related to the presence of ethanol in MLE.
Group Emotion Regulation Therapy for Illness Anxiety Disorder: A Randomized Controlled Trial Emotion Regulation Therapy for Illness Anxiety Disorder
Authors: Aghighi A , Mohammadi N , Rahimi Taghanaki CH , Imani M
Published: February 2022

Background & Objective: People with Illness Anxiety Disorder experience excessive worry and in this regard, they have a lot in common with Generalized Anxiety Disorder. Emotion Regulation Therapy (ERT) is a multifaceted and integrated treatment that is widely used for Generalized Anxiety Disorder and its effectiveness in anxious factors has been established in many studies.
The aim of the present study is to examine Effectiveness of Emotion Regulation Group Therapy in symptom reduction and worry in individuals with Illness Anxiety Disorder through a Randomized Clinical Trial (RCT).
Materials & Methods: This is a Randomized Clinical Trial (RCT) experimental study with pre-test and post-test and control group. Population of the of the present study included all people with Illness Anxiety Disorder in Shiraz in 2019 who went to the psychiatric clinics of Shiraz University of Medical Sciences. The sample was 16 people with Illness Anxiety Disorder who were randomly assigned to the experimental group and the control group. The subjects in the experimental group and the control group were assessed in both pre-test and post-test periods using Structured Clinical Interview for DSM-5 (SCID-5-5), Anxiety and Related Disorders Interview Schedule for DSM-5 (ADIS-5) and The Penn State Worry Questionnaire (PSWQ).
Results: Results showed that group format of emotion regulation therapy significantly improved symptoms of anxiety and worry of individuals with illness anxiety disorder.
Conclusion: Emotion Regulation Therapy throughout intervention in worry and emotion regulation construct which is known as mediators in the treatment of many disorders, significantly improve symptoms and worry of people with Illness Anxiety Disorder.
Investigation of the Effect of High-Intensity Interval Training (HIIT) on the Expression of the Genes miR-126, miR-296, HGS and VEGF-A Protein Levels in Tumor Tissue in Female Mice
Authors: Farsi S , Ghaedi H , Nasiri Ivanaki M
Published: February 2022

Background & Objective: The studies of the last two decades have shown that regular training is associated with the reduction of mortality among patients with breast cancer, and has an important role in inhibiting breast cancer progression as well as treatment of the disease. However, the micro-molecular mechanisms involved are not fully understood yet. However, the aim of the present study was to investigate the effect of a high-intensity interval training (HIIT) on the expression of miR-126, miR-296, HGS gene, and VEGF-A protein level in tumor tissue of the mice with breast cancer.  
Materials & Methods: For this purpose, 12 BALB/c mice (6-8 weeks, weight 19 ± 1.05 g), after induction of cancer (MC4-L2 subcutaneous injection into the right side of the mice), were randomly divided into two groups with 6 in each group: HIIT and control. Each session of HIIT group program includes six intervals of three minutes and 20 seconds with an intensity of 85 to 90 percent of VO2max and 1-minute recovery with 30 to 35 percent VO2max intensity between each interval; and the animals were sacrificed 24 hours after the last training session and the expression of miR-126, miR-296, HBS gene and VEGF protein levels in tumor tissues were examined.
Results: The statistical results showed that the implementation of HIIT significantly reduced the expression of miR-296 and subsequently increased the HGS gene expression and led to increased expression levels of miR-126 and decreased levels of VEGF-A protein in the training group compared to the control group (p<0.05).
Conclusion: It seems that HIIT, by suppressing tumor angiogenesis signaling pathways, could be an effective intervention to inhibit the growth of breast tumors.
Effects of Stress-Induced Glucocorticoids on Reproductive Dysfunction in Men
Authors: Nateghian Z , Aliabadi A , Aliabadi E
Published: February 2022

There are different factors affecting the reproductive fitness of organisms, such as the ecological and environmental factors, resource availability, and stress within their habitat. The challenging incidents in the organism’s environment result in activation of the response system of central stress mediated with the hypothalamic-pituitary-adrenal (HPA) axis. This axis’s regulatory function controls such items as immune and cardiovascular functions, metabolisms, and reproductive system. Its activation shows reproductive function through various stressors. Through up-regulating glucocorticoids, stress can adversely influence fertility. Clinical studies and experimental data have demonstrated that stress signaling can have a mediatory effect during direct actions in gonads and reproductive system. The focus of this review is on the stress mechanisms via up-regulating glucocorticoids on male reproductive dysfunction. The individuals with abnormal Hospital Anxiety and Depression Scale (HADS) had higher serum FSH and LH and lower serum total testosterone compared to those with normal HADS. Besides, it was observed that in individuals with abnormal HADS, morphologically normal spermatozoa, sperm count, and motility are lower. For infertility of male cases, stress management is needed.
Challenges and Promotion Factors in Women’s Leadership in Nursing
Authors: Majidipour P , Boland Hematan K , Salehi M
Published: February 2022

Background & objective: Gender equity is imperative to the attainment of healthy lives and well-being of all, and promoting gender equity in leadership in the health sector is an important part of this endeavour, the present study aimed to evaluate the experiences of female educational supervisors on leadership challenges in Kermanshah hospitals.
Materials & methods: In this ante narrative study, the required data were collected in an individual semi-structured interview. Totally 12 nurses working in hospitals of Kermanshah city were selected by targeted sampling method. Analysis was done by content analysis.
Results: According to the research findings, the extracted themes included low self-confidence and the impact of professional role conflicts and family preferences. The factors of self-control were moral competence and purposefulness.
Conclusion: The results of this study can be beneficial to policymakers, human resource managers, educational planners, and leaders at all health system levels.
AmelioratingEffects of SaturejaedmondiBriqEssential Oil on Reproductive Parameters in Pentylenetetrazol Induced Epilepsy Model inAdult Male Rats
Authors: Bohlouli S , Mahmoodi G
Published: February 2022

Background& Objective: Epilepsy is a common neurological disorder that causes unpredictable, recurrent seizures. Oxidative stress and epilepsy have negative effects on the reproductive system and cause infertility. Antioxidants are effective in reducing infertility disorders. Satureja edmondi Briq is known as a powerful antioxidant that can reduce the effects of oxidative stress. The aim of this study was to evaluate the effects of Saturejaedmondi on reproductive parameters in pentylenetetrazol (PTZ)-induced epileptic and normal male rats.
Materials & Methods: A total of 48 Wistar adult male rats were used in this experimental study. Animals were randomized into normal and kindled groups that were treated with 150 and 300 ppmS. edmondi essential oil. At the end of the study, the rats’ testes were removed following anesthesia. The testes were weighed, and sperm parameters were measured. Data were analyzed by one‐way ANOVA test, and P<0.05 was considered statistically significant.
Results: This study showed that sperm parameters, including sperm count, sperm viability, and progressive sperm motility significantly decreased in epileptic rats compared to normal rats (p≤.001). These parameters significantly increased at 150 and 300 ppm doses of S. edmondi essential oil in the Kindled groups) p≤.001 (. Sperm parameters significantly increased at 300 ppm dose of S. edmondi essential oil in normal groups (p≤.001). Moreover, changes in testis weight were not significant in the treatment groups.
Conclusions: Satureja edmondi Briq, with abundant antioxidant compounds, improves the pathological changes induced by testicular oxidative stress in tic rats. S. edmondi as a good source of antioxidants can improve sperm parameters and reproductive potential in PTZ-induced epileptic male rats.
Manualized Equine-Assisted Therapy Protocol for Clients with Autism Spectrum Disorder
Authors: McKissock H. Blair , Bowen Ashley , Dawson Shay , Eldridge Lori , McIntire Jordan , Stanojevic Cedomir , Tamas Daniela , McCormick Bryan
Published: February 2022

Equine-assisted therapy (EAT) is an increasingly popular intervention for people with various disabilities and diagnoses. However, a lack of evidence-based protocols has hampered efforts to provide standardization of treatment. The Galloping Towards Success (GTS) protocol was designed specifically for clients with moderate to severe autism spectrum disorder (ASD) and is described in this paper. The 15-week manualized EAT protocol was previously tested across multiple sites in Serbia and the U.S. (Dawson et al., 2022) demonstrating the protocol’s preliminary effectiveness in increasing social skills in 9 out of 10 individuals with moderate to severe ASD. This manuscript aims to provide professionals with information regarding the GTS 15-week protocol, including an introductory overview, description of participants, assessment, planning weekly intervention activities, evaluation procedures, documentation, limitations, and author comments. This protocol will help create consistency in facilitation among Certified Therapeutic Recreation Specialists (CTRS ) who use equine-assisted therapy to treat adolescents and young adults with moderate to severe ASD while equipping researchers with the means to conduct future evidence-based research in the area of equine-assisted therapies.
Double Haploids for Vegetable Crop Improvement: A Review
Authors: Aruna S. , Rafeekher M. , Gowda Pooja P. , Anil Ajin S. , Anjaly V.
Published: February 2022

Vegetables are the richest source of vitamins and minerals and play a major role in nutritional security. The primary objective of vegetable breeding is enhancing production and productivity. Breeders use various conventional and non-conventional breeding approaches for genetic advance. Recent advances in biotechnology helps to enhance the efficiency and shorten the time required to achieve the fixed goals in a breeding program, as well as to address the economic and ecological goals. Among these, haploid (H) and doubled haploid (DH) production through gametic embryogenesis has long been recognized as a valuable tool to help crop improvement. Haploid plants are the sporophytes with a gametophytic chromosome number and doubled haploids (DH) are haploids that have undergone chromosome duplication. Haploids and double haploids occur spontaneously in nature. Haploids can also be induced artificially by various techniques such as wide hybridization, pollination with irradiated pollens androgenesis, gynogenesis and finally further chromosome doubling results in double haploids. Production of double haploids in vegetables will shorten the breeding cycle and also DH technology is useful in reverse breeding, CMS line production, gene stacking and various other genetic studies.
Using breakout rooms in online language teaching: Advantages and disadvantages
Authors: Mirzoeva Leila Yurievna
Published: February 2022

Under the conditions of the pandemic, language teachers face a variety of challenges on effective ways of teaching. Current literature has purported the effectiveness of breakout rooms being an effective method of teaching language online. The purpose of this study was to identify whether online teaching tools help students to study language and keep them being motivated, or not. To study the impact of breakout rooms application, the following participants were chosen: 3 groups of second-year IT students whose level of English is considered as Pre-Intermediate; the total number of students was 34. The study conducted classes in 2 experimental groups using the breakout rooms option, and in 1 controlling group where breakout rooms were not used. Data was collected using semi-structured interviews. The findings of this study show that students’ opinion concerning breakout rooms application was rather positive; thus, they focus on the opportunities for brainstorming in breakout rooms.
 
Keywords:  breakout rooms; business English; online learning; students’ motivation
Functional Limitations, Post-Traumatic Stress Disorder, and College Adjustment in Student Veterans: A Mediation Analysis Study
Authors: Umucu Emre , Rumrill Phillip , Chiu Chung-Yi , Ghosh Arpita
Published: February 2022

Purpose

The purpose of this study was to examine whether functional limitations mediate the relation between PTSD symptoms and college life adjustment in student veterans with PTSD symptoms.

Methods

A total of 232 student veterans with PTSD symptoms were recruited for this study. Participants were predominantly male (84.5%; females = 15.5%). Participants’ ages ranged from 18 to 54 years (M = 28.43, SD = 5.42). Correlational analyses were conducted to calculate the relationships among study variables. We also conducted a mediation analysis to examine whether functional limitations mediate the relationship between PTSD symptoms and college life adjustment.

Results

The mediation analysis indicated that the effect of PTSD symptoms on college adjustment can be partially explained by functional limitations.

Conclusion

Our results have potentially important implications for rehabilitation counseling researchers and clinicians in the COVID-19 era.
Conflict Appraisals and Trauma Symptoms in Children Exposed to Intimate Partner Violence
Authors: Cochran Kara A. , Bogat G. Anne , Levendosky Alytia A. , Martinez-Torteya Cecilia
Published: February 2022

Children exposed to intimate partner violence (IPV) are at risk for posttraumatic stress symptoms (PTSS) and alterations in hypothalamic-pituitary-adrenal (HPA) axis functioning. The current study investigated children’s threat and self-blame appraisals about parental conflict as potential mechanisms leading to these adverse outcomes. Parent-child relationships were also examined. The sample consisted of 119 10-year-olds and their mothers who were recruited from the community as part of a larger study of IPV. Children’s reports of IPV directed at their mother in the past year were not associated with PTSS; however, IPV exposure was associated with attenuated cortisol output in response to a social stressor. IPV exposure was also associated with greater threat appraisals and poorer quality parent-child relationships. These results provide further evidence that witnessing IPV is threatening for children, has negative consequences for parent-child relationships, and can impact children’s HPA axis functioning.
Kualitas dan Tingkat Maturasi Oosit Kucing Domestik dari Ovarium yang Disimpan dalam Waktu dan Media yang Berbeda
Authors: Widyasanti Ni Wayan Helpina , Kaiin Ekayanti Mulyawati , Setiadi Mohamad Agus , Karja Ni Wayan Kurniani
Published: February 2022

Penelitian ini bertujuan untuk mengevaluasi kualitas dan tingkat maturasi oosit kucing domestik yang disimpan dalam waktu dan media yang berbeda. Ovarium yang diperoleh setelah ovaryohisterectomy disimpan dalam tabung steril dan cara penyimpanannya dibagi menjadi tiga perlakuan , yaitu: 1) tanpa media, 2) berisi NaCl 0,9% atau 3) berisi PBS. Ovarium tersebut kemudian dibawa ke laboratorium dengan termos yang berisi NaCl 0,9% dengan suhu 35-37°C atau dengan cooler box suhu 4°C. Sampel ovarium suhu 4°C kemudian disimpan dalam refrigerator dengan suhu 4°C selama 24 dan 48 jam. Oosit dari ovarium yang dibawa dengan suhu suhu 35-37°C dikoleksi dalam waktu di bawah enam jam setelah sampai di laboratorium. Pada akhir penyimpanan, oosit dikoleksi dan dievaluasi kualitasnya. Selanjutnya, oosit dimaturasi dan dievaluasi tingkat maturasinya. Hasil dari penelitian ini menunjukkan bahwa berdasarkan morfologinya kualitas oosit kucing tidak dipengaruhi oleh waktu dan jenis media selama penyimpanan (P>0,05). Tingkat maturasi oosit untuk mencapai tahap MII mulai menurun (P<0,05) pada ovarium yang disimpan tanpa media maupun dengan PBS pada 24 jam periode penyimpanan, sedangkan oosit yang berasal dari ovarium yang disimpan dengan NaCl 0,9% mulai menurun (P<0,05) pada 48 jam periode penyimpanan. Simpulan pada penelitian ini adalah penyimpanan ovarium dengan atau tanpa media selama 48 jam tidak memengaruhi morfologi oosit kucing namun memengaruhi tingkat maturasi oosit kucing.