bluuebunny/crossref_metadata_2025 huggingface dataset:
The Sense of Time While Watching a Dance Performance
Authors: Deinzer Vanessa , Clancy Liam , Wittmann Marc
Published: December 2017

Although the judgment of time is an important experience embedded in the context of cognitive and emotional appraisal of events, there are few studies concerning perceived time within an ecologically valid context. Watching a cultural event such as a dance performance is a paradigmatic situation in which viewers perceive time differently as a function of performance characteristics and viewers’ personal engagement. We staged two dance pieces that differed in speed of movement performed by a professional female dancer. Fifty-two participants watched both performances in counterbalanced order and rated their impressions, senses of self, and perceptions of space and time. On average, spectator-participants liked the faster dance better than the slower dance and felt more positive afterward. During the fast dance, participants focused more on the dancer’s breathing and less on their own body. Participant’s subjective perceptions were that time seemed to pass more slowly during the slow dance, but participants estimated the faster dance to have lasted longer. Path analyses revealed that paying attention to one’s bodily signals mediated the feeling of time. As typical flow states are characterized by positive feelings during an activity, as well as by a diminished sense of self and time, these results suggest that the participant’s average response reflected a relatively stronger flow state in the fast dance condition. Future studies might be encouraged assessing time perception in a variety of real-life situations. Participants’ responses could then be assessed with different methodological approaches.
Impact of Preoperative Anemia on Outcomes in Adults Undergoing Elective Posterior Cervical Fusion
Authors: Phan Kevin , Dunn Alexander E. , Kim Jun S. , Capua John Di , Somani Sulaiman , Kothari Parth , Lee Nathan J. , Xu Joshua , Dowdell James E. , Cho Samuel K.
Published: December 2017

Study Design:

Retrospective analysis of prospectively collected data.

Objectives:

Few studies have investigated the role of preoperative anemia on postoperative outcomes of posterior cervical fusion. This study looked to investigate the potential relationship between preoperative anemia and postoperative outcomes following posterior cervical spine fusion.

Methods:

Data from patients undergoing elective posterior cervical fusions between 2005 and 2012 was collected from the American College of Surgeons National Surgical Quality Improvement Program database using inclusion/exclusion criteria. Multivariate analyses were used to identify the predictive power of anemia for postoperative outcomes.

Results:

A total of 473 adult patients undergoing elective posterior cervical fusions were identified with 106 (22.4%) diagnosed with anemia preoperatively. Anemic patients had higher rates of diabetes ( P = .0001), American Society of Anesthesiologists scores ≥3 ( P < .0001), and higher dependent functional status prior to surgery ( P < .0001). Intraoperatively, anemic patients also had higher rates of neuromuscular injuries ( P = .0303), stroke ( P = .013), bleeding disorders ( P = .0056), lower albumin ( P < .0001), lower hematocrit ( P < .0001), and higher international normalized ratio ( P = .002). Postoperatively, anemic patients had higher rates of complications ( P < .0001), death ( P = .008), blood transfusion ( P = .001), reoperation ( P = .012), unplanned readmission ( P = .022), and extended length of stay (>5 days; P < .0001).

Conclusions:

Preoperative anemia is linked to a number of postoperative complications, which can increase length of hospital stay and increase the likelihood of reoperation. Identifying preoperative anemia may play a role in optimizing and minimizing the complication rates and severity of comorbidities following posterior cervical fusion.
Functional Outcome of Neurologic-Controlled HAL-Exoskeletal Neurorehabilitation in Chronic Spinal Cord Injury: A Pilot With One Year Treatment and Variable Treatment Frequency
Authors: Jansen Oliver , Schildhauer Thomas A. , Meindl Renate C. , Tegenthoff Martin , Schwenkreis Peter , Sczesny-Kaiser Matthias , Grasmücke Dennis , Fisahn Christian , Aach Mirko
Published: December 2017

Study Design:

Longitudinal prospective study.

Objectives:

Whether 1-year HAL-BWSTT of chronic spinal cord injured patients can improve independent ambulated mobility further as a function of training frequency, after an initial 3-month training period.

Methods:

Eight patients with chronic SCI were enrolled. They initially received full standard physical therapy and neurorehabilitation in the acute/subacute posttrauma phase. During this trial, all patients first underwent a daily (5 per week) HAL-BWSTT for 12 weeks. Subsequently, these patients performed a 40-week HAL-BWSTT with a training session frequency of either 1 or 3 to 5 sessions per week. The patients’ functional status including HAL-associated treadmill-walking time, -distance, and -speed with additional analysis of gait pattern, and their independent (without wearing the robot suit) functional mobility improvements, were assessed using the 10-Meter-Walk Test (10MWT), Timed-Up-and-Go Test (TUG) and 6-Minute-Walk Test (6MinWT) on admission, at 6 weeks, 12 weeks, and 1 year after enrollment. The data were analyzed separately for the 2 training frequency subgroups after the initial 12-week training period, which was identical in both groups.

Results:

During the 1-year follow-up, HAL-associated walking parameters and independent functional improvements were maintained in all the patients. This result held irrespective of the training frequency.

Conclusions:

Long-term 1-year maintenance of HAL-associated treadmill walking parameters and of improved independent walking abilities after initial 12 weeks of daily HAL-BWSTT is possible and depends mainly on the patients’ ambulatory status accomplished after initial training period. Subsequent regular weekly training, but not higher frequency training, seems to be sufficient to preserve the improvements accomplished.
Race Counts: Racial and Ethnic Data on the U.S. Census and the Implications for Tracking Inequality
Authors: Strmic-Pawl Hephzibah V. , Jackson Brandon A. , Garner Steve
Published: December 2017

This article is a critical review of racial and ethnic categories on the U.S. Census with a focus on how the census categories affect opportunities to track racial and ethnic inequality. The authors summarize how motivations behind the census categories changed from a historical basis in controlling people of color and protecting Whiteness toward a contemporary orientation around equity. Yet, many issues remain that confound the racial and ethnic census data, which are then used in research. A look at these issues and possible changes for the upcoming 2020 census serves as a critical reminder of the limitations of the census data. Taking this information into account, the authors conclude with comments and suggestions on the principles underlying racial and ethnic data collection on the census and the implications for tracking inequality.
The Anti-oppressive Value of Critical Race Theory and Intersectionality in Social Movement Study
Authors: Watkins Liu Callie
Published: December 2017

Social movements can be important mechanisms of social change for vulnerable populations as the formal mechanisms of policy and legislation tend to be in the hands of the powerful in society. Academic scholarship can play an important role in challenging or reinforcing social power dynamics. This reality makes it important to critically interrogate social movement knowledge production and use anti-oppressive frameworks for social movement scholarship. Sociology has contributed greatly to social movement literature, and the American Sociological Association (ASA), especially the section of Collective Behavior and Social Movements (CBSM), is a central site of academic credibility and scholarship. This examination draws on critical race theory and intersectionality to analyze 10 years of award-winning books from the CBSM, specifically recipients of the Charles Tilly Award for Best Book. These books are prominently positioned with respect to the production of knowledge, as well as the study of social movements. This analysis shows the absence of critical race theory and intersectionality in core of social movement scholarship and identifies a pattern of erasure and marginalization of vulnerable populations in the award-winning books.
Initial Experience and Usage Patterns With the Owlet Smart Sock Monitor in 47,495 Newborns
Authors: Dangerfield Michelle I. , Ward Kenneth , Davidson Luke , Adamian Milena
Published: December 2017

We report the largest experience, to our knowledge, of home cardiorespiratory monitoring in 47,495 newborns using the novel Owlet Smart Sock (OSS) technology (October 2015 to May 2017). On average, 47,495 newborns were monitored for 6 months, 4.5 d/wk, 9.9 h/d. Continuous readings of oxygen saturation and heart rate were obtained from 39,626 full-term newborns. OSS users were likely first-time parents in their 30s with at least a college degree; 37% had a healthcare professional in the family; and 28% were at or below median income level per the US Census Bureau. “Peace of mind” was the reason to own an OSS in 75%, and 82% of parents followed Safe Sleep Guidelines. A total of 94% of parents reported a better quality of sleep. The fast and continuous pace of device adoption and reported experience suggest excellent parental acceptance of the OSS. Prospective studies are warranted to further evaluate its applications in the high-risk newborn population.
Placing the Urban in its Rural Context: A Mixed Methods Case Study of a ‘Census Town’ in India
Authors: Sircar Srilata
Published: December 2017

How do we understand the contemporary urban condition, especially in the context of the developing world? Through a mixed methods case study of a ‘census town’ in West Bengal, India, this article seeks to demonstrate that the contemporary urban, in form and content, is the imprint of the rural. Based on narrative analysis of oral history interviews and statistical data from a household survey, the article argues that the urban here is a spatial articulation of the specific historical experiences of people inhabiting the context and brings into relief the continuities between agrarian relations and urban forms.
Glyburide/Glipizide Combination Therapy in Type 2 Diabetes
Authors: Jaber Linda A
Published: December 2017

Objective

Research has determined differences in the pharmacokinetics and therapeutic actions of glyburide and glipizide. The goal of this study was to evaluate the hypoglycemic effects of glyburide/glipizide combination therapy in the management of patients with diabetes not adequately controlled on either agent alone.

Methods

Nine patients (3 men, mean age 50.6 ± 11 y) who were hyperglycemic on either glyburide or glipizide monotherapy continued their previous regimen with doses titrated up to maximum daily doses and dietary therapy for 4 weeks, and then they were placed on morning glipizide/evening glyburide combination therapy for 12 weeks.

Results

Combination therapy had no significant effect on glycemic control; no differences in glycosylated hemoglobin (HbAIC) were observed (baseline, 15.3% ± 3.6%; monotherapy, 14.8% ± 3.3%; combination, 13.4% ± 3.5%). However, during combined glyburide/glipizide therapy, fasting plasma glucose was significantly reduced by 53.4 ± 20.0 mg/dL in young (age <50 y) and increased by 73.7 ± 26.9 mg/dL in older subjects. HbAIC was reduced by 3.8% ± 4.0% in young and increased by 1.7% ± 1.3% in older subjects. No significant changes in blood pressure, body weight, or lipid parameters occurred.

Conclusions

Our preliminary data indicate the limited usefulness of combined glyburide/glipizide therapy. The modest reduction in hyperglycemia observed in patients younger than 50 years of age warrant future studying.
Transforming growth factor beta (TGF-β) in adolescent chronic fatigue syndrome
Authors: Wyller Vegard Bruun , Nguyen Chinh Bkrong , Ludviksen Judith Anita , Mollnes Tom Eirik
Published: December 2017

Background

Chronic fatigue syndrome (CFS) is a prevalent and disabling condition among adolescent. The disease mechanisms are unknown. Previous studies have suggested elevated plasma levels of several cytokines, but a recent meta-analysis of 38 articles found that of 77 different cytokines measured in plasma, transforming growth factor beta (TGF-β) was the only one that was elevated in patients compared to controls in a sufficient number of articles. In the present study we therefore compared the plasma levels of the three TGF-β isoforms in adolescent CFS patients and healthy controls. In addition, the study explored associations between TGF-β levels, neuroendocrine markers, clinical markers and differentially expressed genes within the CFS group.

Methods

CFS patients aged 12–18 years (n = 120) were recruited nation-wide to a single referral center as part of the NorCAPITAL project (ClinicalTrials ID: NCT01040429). A broad case definition of CFS was applied, requiring 3 months of unexplained, disabling chronic/relapsing fatigue of new onset, whereas no accompanying symptoms were necessary. Healthy controls (n = 68) were recruited from local schools. The three isoforms of TGF-β (TGF-β1, TGF-β2, TGF-β3) were assayed using multiplex technology. Neuroendocrine markers encompassed plasma and urine levels of catecholamines and cortisol, as well as heart rate variability indices. Clinical markers consisted of questionnaire scores for symptoms of post-exertional malaise, inflammation, fatigue, depression and trait anxiety, as well as activity recordings. Whole blood gene expression was assessed by RNA sequencing in a subgroup of patients (n = 29) and controls (n = 18).

Results

Plasma levels of all three isoforms of TGF-β were equal in the CFS patients and the healthy controls. Subgrouping according to the Fukuda and Canada 2003 criteria of CFS did not reveal differential results. Within the CFS group, all isoforms of TGF-β were associated with plasma cortisol, urine norepinephrine and urine epinephrine, and this association pattern was related to fatigue score. Also, TGF-β3 was related to expression of the B cell annotated genes TNFRSF13C and CXCR5.

Conclusions

Plasma levels of all TGF-β isoforms were not altered in adolescent CFS. However, the TGF-β isoforms were associated with neuroendocrine markers, an association related to fatigue score. Furthermore, TGF-β3 might partly mediate an association between plasma cortisol and B cell gene expression.

Trial registration Clinical Trials NCT01040429
The complete genome sequence of the rumen bacterium Butyrivibrio hungatei MB2003
Authors: Palevich Nikola , Kelly William J. , Leahy Sinead C. , Altermann Eric , Rakonjac Jasna , Attwood Graeme T.
Published: December 2017

Butyrivibrio hungatei MB2003 was isolated from the plant-adherent fraction of rumen contents from a pasture-grazed New Zealand dairy cow, and was selected for genome sequencing in order to examine its ability to degrade plant polysaccharides. The genome of MB2003 is 3.39 Mb and consists of four replicons; a chromosome, a secondary chromosome or chromid, a megaplasmid and a small plasmid. The genome has an average G + C content of 39.7%, and encodes 2983 putative protein-coding genes. MB2003 is able to use a variety of monosaccharide substrates for growth, with acetate, butyrate and formate as the principal fermentation end-products, and the genes encoding these metabolic pathways have been identified. MB2003 is predicted to encode an extensive repertoire of CAZymes with 78 GHs, 7 CEs, 1 PL and 78 GTs. MB2003 is unable to grow on xylan or pectin, and its role in the rumen appears to be as a utilizer of monosaccharides, disaccharides and oligosaccharides made available by the degradative activities of other bacterial species.
The genomic study of an environmental isolate of Scedosporium apiospermum shows its metabolic potential to degrade hydrocarbons
Authors: Morales Laura T. , González-García Laura N. , Orozco María C. , Restrepo Silvia , Vives Martha J.
Published: December 2017

Crude oil contamination of soils and waters is a worldwide problem, which has been actively addressed in recent years. Sequencing genomes of microorganisms involved in the degradation of hydrocarbons have allowed the identification of several promoters, genes, and degradation pathways of these contaminants. This knowledge allows a better understanding of the functional dynamics of microbial degradation. Here, we report a first draft of the 44.2 Mbp genome assembly of an environmental strain of the fungus Scedosporium apiospermum. The assembly consisted of 178 high-quality DNA scaffolds with 1.93% of sequence repeats identified. A total of 11,195 protein-coding genes were predicted including a diverse group of gene families involved in hydrocarbon degradation pathways like dioxygenases and cytochrome P450. The metabolic pathways identified in the genome can potentially degrade hydrocarbons like chloroalkane/alkene, chorocyclohexane, and chlorobenzene, benzoate, aminobenzoate, fluorobenzoate, toluene, caprolactam, geraniol, naphthalene, styrene, atrazine, dioxin, xylene, ethylbenzene, and polycyclic aromatic hydrocarbons. The comparison analysis between this strain and the previous sequenced clinical strain showed important differences in terms of annotated genes involved in the hydrocarbon degradation process.
Single-Nucleotide Variations of the Human Nuclear Hormone Receptor Genes in 60,000 Individuals
Authors: Mackeh Rafah , Marr Alexandra K , Dargham Soha R , Syed Najeeb , Fakhro Khalid A , Kino Tomoshige
Published: December 2017

Nuclear hormone receptors (NRs) mediate biologic actions of lipophilic molecules to gene transcription and are phylogenetically and functionally categorized into seven subfamilies and three groups, respectively. Single-nucleotide variations (SNVs) or polymorphisms are genetic changes influencing individual response to environmental factors and susceptibility to various disorders, and are part of the genetic diversification and basis for evolution. We sorted out SNVs of the human NR genes from 60,706 individuals, calculated three parameters (percentage of all variants, percentage of loss-of-function variants, and ratio of nonsynonymous/synonymous variants in their full protein-coding or major domain–coding sequences), and compared them with several valuables. Comparison of these parameters between NRs and control groups identified that NRs form a highly conserved gene family. The three parameters for the full coding sequence are positively correlated with each other, whereas four NR genes are distinct from the others with much higher tolerance to protein sequence-changing variants. DNA-binding domain and N-terminal domain are respectively those bearing the least and the most variation. NR subfamilies based on their phylogenetic proximity or functionality as well as diversity of tissue distribution and numbers of partner molecules are all not correlated with the variation parameters, whereas their gene age demonstrates an association. Our results suggest that the natural selection driving the NR family evolution still operates in humans. Gene age and probably the potential to adapt to various new ligands, but not current functional diversity, are major determinants for SNVs of the human NR genes.
ΠΑΡΟΥΣΙΑΣΗ ΑΡΘΡΩΝ
Authors: ΣΤΑΘΟΠΟΥΛΟΥ ΧΑΡΟΥΛΑ , ΤΖΕΚΑΚΗ ΜΑΡΙΑΝΝΑ
Published: December 2017

Συνοπτική παρουσίαση άρθρων του τεύχους
Η Διακυβερνητική Συνδιάσκεψη του 1996 και η θεσμική μεταρρύθμιση στην Ευρωπαϊκή Ένωση
Authors: Καζάκος Πάνος
Published: December 2017

Δεν διατίθεται περίληψη στα ελληνικά
Α.-Ι. Λ. ΜΕΤΑΞΑΣ, Προεισαγωγικά για τον πολιτικό λόγο: Δεκατέσσερα μαθήματα για το στυλ, Αθήνα-Κομοτηνή, εκδ. Αντ. Ν. Σάκκουλα,1995.
Authors: Λαγόπουλος Α.-Φ.
Published: December 2017

[Δεν διατίθεται περίληψη / no abstract available]
Α. Γ. ΠΛΑΤΙΑΣ, Το Νέο Διεθνές Σύστημα: Ρεαλιστική Προσέγγιση Διεθνών Σχέσεων, Αθήνα, Παπαζήσης, 1995
Authors: Παπασωτηρίου Χαράλαμπος
Published: December 2017

Δεν διατίθεται περίληψη / no abstract available
Δημοκρατικοί θεσμοί και οικονομική παρακμή στην υποσαχαρική Αφρική
Authors: Χουλιάρας Αστέρης Κ.
Published: December 2017

Δεν διατίθεται περίληψη στα ελληνικά
Emerging concepts and recent advances in basal cell carcinoma
Authors: Totonchy Mariam , Leffell David
Published: December 2017

Basal cell carcinoma (BCC) is the most common malignancy worldwide, arising from non-keratinizing cells within the basal layer of the epidermis. The incidence of BCC continues to rise annually, increasing the burden of management of these carcinomas and the morbidity associated with their treatment. While surgical interventions such as Mohs micrographic surgery and surgical excision are the standard of care and yield the highest cure rates, the number of non-surgical interventions approved for the treatment of BCC continues to expand. We review various surgical and non-surgical approaches to the treatment of BCC, focusing on targeted molecular therapies that are approved for locally advanced or recurrent disease.
Advancing psychosocial care in cancer patients
Authors: Grassi Luigi , Spiegel David , Riba Michelle
Published: December 2017

Cancer is a devastating disease causing significant psychological problems among patients and their families. In the past few decades, there have been growing implementation and dissemination of screening methods for the psychological consequences of cancer, including distress, depression, anxiety, post-traumatic stress, and demoralisation. Also, guidelines for the management of psychological distress have been developed and endorsed by a number of scientific cancer associations. This review examines some of the most significant related issues, also focusing on recent advances in psychosocial and psychopharmacological interventions as a part of a mandatory, integrated, and comprehensive approach to cancer care.
Case Report: Propranolol increases the therapeutic response to temozolomide in a patient with metastatic paraganglioma
Authors: Díaz-Castellanos Miguel-Angel , Gómez de las Heras Karina Villar , Díaz-Redondo Tamara , González-Flores Encarnación , Albiñana Virginia , Botella Luisa-María
Published: December 2017

This case report presents the clinical evolution and management of a patient with a hereditary paraganglioma syndrome. This disease is characterized by rare tumors of neural crest origin that are symmetrically distributed along the paravertebral axis from the base of the skull and neck to the pelvis. In addition, these patients may develop renal cancer, gastrointestinal stromal tumors, pituitary adenomas, and bone metastasis in some cases. To date no successful therapeutic treatment has been reported. Total resection with postoperative radiotherapy and chemotherapy have been advocated, especially for the multiple metastasis. Here we show how the combination of high doses of the beta blocker propranolol (3 mg/Kg/day) and the DNA intercalating agent, temozolomide, has been successful in the treatment of a SDHA metastatic paraganglioma.
MODERN VISION ON ADAPTATION MECHANISMS OF WARM-BLOODED ORGANISM TO THE TEMPERATURE STRESS
Authors: Литовченко Екатерина , Litovchenko Ekaterina , Коршунова Наталья , Korshunova Natalya , Юречко Ольга , Yurechko Olga , Войтус Леонид , Voytus Leonid
Published: December 2017

In the review of the literature, data on the possibility of adaptation reactions of a warm-blooded organism to cold and heat stress are described in detail. The scientific experience of application of adaptogenic products in the correction of overheating and cooling of the organism is discussed. The theoretical problems of the toxic effect of the temperature factor of the environment on cognitive abilities of laboratory animals and humans are revealed. The article presents the historical data about the study of these issues over the last 50 years.
Radiological Aspects of Liquid Radioactive Waste Management from Nuclear Power Plant Operation
Authors: Кочетков О. , Kochetkov O. , Иванов Е. , Ivanov E. , Шаров Д. , Sharov D.
Published: December 2017

Purpose: The prospects and scale of the further development of nuclear energy depend to a large extent on the solution of the radioactive waste management (RW) problem. Special attention is given to management of the liquid radioactive waste (LRW), which poses the main potential hazard to the public and the environment, since LRW storage can lead to leaks into the environment.

The purpose of the paper is to examine the radiological aspects of LRW management from nuclear power plants (NPPs) operation and to study the influence of the list of radionuclides controlled in RW on the evaluation of the efficiency of LRW treatment technology and on the validity of radioactive waste characterization and classification.

Material and methods: The work is based on analysis of public materials (scientific publications, legal documents, international standards, recommendations of international organizations) in the area of LRW treatment and conditioning technologies, and methods of radioactive waste characterization, including information about accepted lists of controlled radionuclides.

Results: It is shown that an unreasonable reduction of the list of controlled radionuclides can lead to a significant underestimation of the radiological hazard of RW packages transferred for disposal. In order to optimize the volume of RW radiation control, the radionuclide vector technology was proposed. It is stated that the technology is not universal and its application in each specific case requires additional justification. It is shown that the correctness of accounting for the radiological characteristics of radioactive waste can significantly influence the evaluation of the efficiency of the radioactive waste treatment technology. A possible approach to determining the acceptability of LRW treatment technology based on the characteristics of the final products formed is suggested.

Conclusions: There is no universal approach to solve the problems of LRW treatment at the moment. A survey of the characteristics of LRW (chemical, physical, radiation) accumulated and formed during the operation of NPP with various types of reactors (VVER, RBMK, BN) should be performed to determine the initial requirements for LRW treatment technologies. A comprehensive analysis of the efficiency of LRW treatment technologies at all Russian NPPs is of interest with taking into account radionuclides that determine the radiological hazard of radioactive waste after the final disposal.
Effect of Correction of Gamma-Radiation Absorption in the Study of Myocardial Perfusion by SPECT/CT
Authors: Хачирова Э. , Hachirova E. , Самойленко Л. , Samoylenko L. , Шевченко О. , Shevchenko O.
Published: December 2017

Purpose: Assessment of the impact of absorption correction (AC) on quantitative parameters of myocardial perfusion and determination of the extent of stress-induced myocardial microcirculation disorders on SPECT / CT in patients with chest pain and unchanged coronary arteries.

Material and methods: the study included 35 patients, each of whom was carried a selective coronary angiography and rest/stress SPECT/CT of the myocardium with 99mTc -MIBI with- and without CA.

Results: In all patients with stress-induced myocardial ischemia was detected both without and with AC images. However, quantitative parameters of myocardial perfusion were lower after the AC: SSS 6.9 ± 1.2 vs. 7.7 ± 1.1; SDS 4.0 ± 0.8 vs. 4.9 ± 0.6; Stress ext. Total 11.2 ± 1.8 vs. 13.0 ± 1.9; Stress TPD total 9.3 ± 1.2 vs.10.9 ± 1.2; TPDi 4.1 ± 1.0 vs.5.9 ± 0.9 (for all p < 0.05). For SRS, Rest ext. Total, and Rest TPD total difference was not significant. The number of hypoperfused segments, according to the segmental analysis, was less after AC and was 126 vs. 153 at rest, 242 vs. 177 under stress.

In women, significant difference was obtained for all parameters, for men – only for the SSS, SDS, Stress ext. Total, Stress TPD total. In patients with BMI ≥25 significant difference for all parameters was obtained. However, patients with the normal BMI (18,5–24,9;WHO, 2004) significant difference was obtained only for Stress ext. Total, Stress TPD total.

Conclusion The use of SPECT/CT with AC allow to detect microcirculatory violations of perfusion and myocardial reserve perfusion in patients with pain in the chest with the unchanged CA, as evidenced by indicators of the average values of quantitative parameters of perfusion scintigram. The most significant impact on the quantitative perfusion parameters was observed in women with well-developed breasts and obese patients. The findings give reason to assume the use of AC to avoid revaluation incidence and severity of stress-induced myocardial perfusion disturbances.
Radionuclide Diagnosis of Prostate Cancer: Positron Emission Tomography with 68Ga-PSMA Inhibitors and Their Pharmaceutical Development
Authors: Ларенков А. , Larenkov A. , Кодина Г. , Kodina G.
Published: December 2017

This review is devoted to the synthesis of the main and most relevant data on the development and clinical use of radiopharmaceuticals (RPs) based on PSMA-inhibitors labeled with 68Ga for the diagnosis of prostate cancer (PC).

The generator method of 68Ga production, which ensures the wide availability of this radionuclide for medical organizations, is the reason for the permanent interest to the RPs based on 68Ga. The development of RPs based on inhibitors of the prostate-specific membrane antigen became the second wave of global excitement about 68Ga-RPs, after labeled derivates of the ocreotide for the diagnosis of neuroendocrine tumors.

PC is one of the most urgent problems of modern oncology. The place of prostate cancer in the structure of the oncological morbidity of the male population, as well as the significance of radionuclide diagnostics in the clinical staging of the disease and the strategy of therapy are considered.

Data on the structure and properties of the prostate-specific membrane antigen (PSMA), its role in the body and expression in the foci of pathological processes are presented. Known PSMA inhibitors and the dependence of their properties on structure are considered.

The main part of the review is devoted to the key results of the pharmaceutical development of RPs based on PSMA-inhibitors labeled with 68Ga. The effect of the fragments (ligand, linker and chelator) on the final radiopharmaceutical molecule on the pharmacokinetics is considered. The review also includes data on the clinical efficacy of PET with 68Ga-PSMA in the diagnosis of PC. Data on the availability of 68Ga-RPs in Russia today, as well as references to regulatory documents that allow the use of such RPs, are presented.

In conclusion, a brief summary of the literature data and conclusions on the most promising radiopharmaceuticals for the diagnosis and therapy of prostate cancer and further perspectives are presented.
When Risk Is Weird: Unexplained Transaction Features Lower Valuations
Authors: Mislavsky Robert , Simonsohn Uri
Published: December 2017

We define transactions as weird when they include unexplained features, that is, features not implicitly, explicitly, or self-evidently justified, and propose that people are averse to weird transactions. In six experiments, we show that risky options used in previous research paradigms often attained uncertainty via adding an unexplained transaction feature (e.g., purchasing a coin flip or lottery), and behavior that appears to reflect risk aversion could instead reflect an aversion to weird transactions. Specifically, willingness to pay drops just as much when adding risk to a transaction as when adding unexplained features. Holding transaction features constant, adding additional risk does not further reduce willingness to pay. We interpret our work as generalizing ambiguity aversion to riskless choice.

The online supplement is available at https://doi.org/10.1287/mnsc.2017.2868 and http://osf.io/fzjuw .

This paper was accepted by Yuval Rottenstreich, judgment and decision making.
CASE STUDIES OF NUCLEAR RESEARCH SOFTWARE DEVELOPMENT
Authors: Yan Huiping , Yatabe Susan
Published: December 2017

Experimental and operational data are valuable assets for the field of nuclear science and technology. It is very important to develop software tools to assist scientists to manage the data effectively and to conveniently access and share the data. This paper presents 5 case studies on software development pertaining to topical areas such as nuclear fuel performance, waste management, biological research, reactor physics, and chemistry analysis at Canadian Nuclear Laboratories (CNL). Each case study illustrates the design and development of the database and user interface for its target research area and end users. While datasets based on flat files are still used in reactor physics studies, full-scale relational databases are developed for most of the other studies. The user interfaces developed for these areas include web applications, desktop applications, and mobile applications. These software tools have become essential parts of the research activities at CNL.
Performance optimization model n 802.11n networks using multi-objective programming
Authors: Medina Carlos Arturo Castillo , Parra Octavio Jose Salcedo , Espitia R. Miguel J.
Published: December 2017

This project aims to develop a method to find an alternative to analyze the
performance of wireless networks (for this case 802.11n) using the Multiobjetive
Programming. They perform three functions with their respective objectives and
constraints finds its solution. The model was validated against and past performance
data against data taken from two wireless networks possess a different complement
infrastructure, this in order to perform a sensitivity analysis.
EQUIPAMENTOS PARA EVENTOS EM BONITO/MS E O PAPEL DO CONVENTION BUREAU
Authors: Martins Lúcia Bento , Lunas Maria Cristiane Fernandes da Silva , Martins Tiago Carvalheiro , Santana José Carlos , Silva Gabriel Francisco Santos da
Published: December 2017

Em uma tentativa estratégica que possui como objetivo principal o aumento do contingente turístico em baixa temporada, o Convention Bureau em parceria com o poder público, desempenham um papel fundamental no desenvolvimento de atividades que apoiam a captação e realização de eventos indutores de fluxo turístico. O presente trabalho teve o objetivo de identificar a estrutura da oferta turística para eventos no município de Bonito. Como procedimentos metodológicos, utilizou-se pesquisas bibliográficas, pesquisa de campo e entrevistas. Como resultados, percebeu-se que entre os principais eventos locais, com grande alcance de público são o Festival de Inverno de Bonito/MS e o Festival da Guavira, além dos eventos técnico-científicos que ocorrem na cidade. Verificou-se ainda que a cidade de Bonito/MS é detentora de uma sólida estrutura de hospedagem, com capacidade de acolher os visitantes e ao mesmo tempo servir como infraestrutura de eventos, e que o Centro de Convenções e o Convention Bureau tem papel fundamental na promoção da cidade enquanto destino turístico não apenas de natureza, mas de eventos também.
HOSPITALIDADE URBANA DO CENTRO HISTÓRICO DE PELOTAS/RS
Authors: Dutra Camila Osório , Caldas Liliane da Cruz , Pinheiro Pedro Mascarenhas de Souza , Bastos Tiago Rodrigues
Published: December 2017

O presente trabalho tem como objeto de estudo a Hospitalidade Urbana do Centro Histórico da cidade de Pelotas/RS. Tendo como objetivo compreender se o Centro Histórico desta cidade, é, ou não, hospitaleiro, através das categorias de análise: Acessibilidade, Identidade e Legibilidade. Para isto, foram realizadas pesquisas bibliográficas e questionários com moradores e turistas em diferentes pontos da cidade. Relatou-se que a hospitalidade de legibilidade se refere, cada indivíduo cada usuário de um espaço tem uma visão, uma percepção, do que é mais interessante, do que é guardado em suas experiências e consequentemente em suas memórias visuais. Além disso, em futuros estudos, outros pontos que podem ser abordados são as condições de acesso em diferentes municípios e as identidades de diferentes cidades.
Seasonal Movements and Relative Abundance of Bearded Seals (Erignathus barbatus) in the Coastal Waters of the Chukotka Peninsula
Authors: Melnikov Vladimir V.
Published: December 2017

Information about bearded seal seasonal distribution in the Pacific Arctic is limited. Bearded seals (Erignathus barbatus Exleben, 1777) from coastal sites along the southern, eastern, and northern Chukotka Peninsula, Russian Federation, were observed most seasons during 1993 – 96, 1998 – 2000, 2002 – 05, and 2010 – 11. These observations provide spatial and temporal information about bearded seal seasonal distribution, movements, and relative numbers in the coastal zones. In winter, bearded seals aggregate on the young ice in the northern part of the Gulf of Anadyr. Numbers gradually increase during March. In springtime (April–May), bearded seals in the northern Gulf of Anadyr are relatively numerous around Nunligran (Cape Achen), but the number is highly variable across years. During spring bearded seals move eastward along the coast from the northern part of the Gulf of Anadyr towards the Bering Strait and then to the north, as the marginal ice edge zone retreats north. These movements to the east and north continue in ice-free water, and by August, the spring migration of bearded seals along the coast of the Chukotka Peninsula ends. In the summer months of August and September, few bearded seals are present in this coastal zone. The southward autumn migration of bearded seals is not evident near the coast, which suggests that it occurs farther from shore.
Prevalence and Patterns of Sugar-Sweetened Beverage Consumption in Canadian Youth: A Northern Focus
Authors: Davis Laura E. , Davison Colleen M.
Published: December 2017

Regular consumption of sugar-sweetened beverages (SSBs) is a well-known risk factor for weight gain, tooth decay, and metabolic syndrome. Rates of SSB consumption in Nunavut specifically, have been noted to be exceptionally high. This study describes consumption rates of specific foods and beverages, with a focus on SSBs, among adolescents in Nunavut, northern Canada as a whole, and the Canadian provinces, using data from the 2010 and 2014 cycles of the Health Behaviour in School-aged Children (HBSC) study to investigate population characteristics and consumption patterns. Comparative analyses of consumption patterns for Nunavut, the three territories combined, and the southern provinces found that in 2010, those who consumed SSBs once a day or more comprised 53.1% of adolescents in Nunavut, 31.1% in the northern territories and 24% in the provinces. Comparable figures for 2014 were 55.0% in Nunavut, but only 27.0% in all the territories, and 19.1% in the provinces. The percentage of adolescents who consumed fruit and vegetables daily was also lower in Nunavut than in the provinces (65.5% vs. 85.3% in 2010, and 57.5% vs. 84.4% in 2014). More Nunavut adolescents consumed sweets and potato chips daily than provincial adolescents (42.6% vs. 27.6% in 2010, and 52.2% vs. 25.2% in 2014). A greater proportion of Nunavut adolescents reported high consumption of SSBs, as well as other energy-dense foods, when compared to adolescents in the three territories combined and in the provinces. These results confirm previous studies but provide a current and comprehensive analysis that can help inform future food and nutrition priorities and programing.
Nfe2l1-silenced insulinoma cells acquire aggressiveness and chemoresistance
Authors: Fu Jingqi , Zheng Hongzhi , Cui Qi , Chen Chengjie , Bao Simeng , Sun Jing , Li Lu , Yang Bei , Wang Huihui , Hou Yongyong , Xu Yuanyuan , Xu Yuanhong , Zhang Qiang , Pi Jingbo
Published: December 2017

The transcription factor nuclear factor erythroid 2-like 1 (NFE2L1 or NRF1) is involved in various critical cell processes such as maintenance of ubiquitin-proteasome system and regulation of the cellular antioxidant response. We previously determined that pancreatic β-cell-specific Nfe2l1-knockout mice had hyperinsulinemia and that silencing of Nfe2l1 in mouse islets or MIN6 insulinoma β-cells induced elevated basal insulin release and altered glucose metabolism. Hypoglycemia is a major issue with aggressive insulinomas, although a role of NFE2L1 in this pathology is not defined. In the present work, we studied the tumorigenicity of Nfe2l1-deficient insulinoma MIN6 cells (Nfe2l1-KD) and sensitivity to chemotherapy. Nfe2l1-KD cells grew faster and were more aggressive than Scramble cells in vitro. In a mouse allograft transplantation model, insulinomas arising from Nfe2l1-KD cells were more aggressive and chemoresistant. The conclusion was amplified using streptozotocin (STZ) administration in an allograft transplantation model in diabetic Akita background mice. Furthermore, Nfe2l1-KD cells were resistant to damage by the chemotherapeutic drugs STZ and 5-fluorouracil, which was linked to binding of hexokinase 1 with mitochondria, enhanced mitochondrial membrane potential and closed mitochondrial potential transition pore. Overall, both in vitro and in vivo data from Nfe2l1-KD insulinoma cells provided evidence of a previously un-appreciated action of NFE2L1 in suppression of tumorigenesis. Nfe2l1 silencing desensitizes insulinoma cells and derived tumors to chemotherapeutic-induced damage, likely via metabolic reprograming. These data indicate that NFE2L1 could potentially play an important role in the carcinogenic process and impact chemosensitivity, at least within a subset of pancreatic endocrine tumors.
El problema de la negatividad en la Ciencia de la lógica de Hegel
Authors: Serey Aguilera Juan
Published: December 2017

En las primeras páginas de la Ciencia de la lógica, el pensar tiene la pretensión de iniciar su propio movimiento sin aceptar ningún pensamiento dado o presuposición como la paradójica y pura autorreferencia del vínculo de ser y nada. De acuerdo conesto, proponemos una lectura que afirma la presencia de una negatividad que explica la actividad inmanente del pensar en el inicio de la Ciencia de la lógica.
Percepción, descripción y explicación en la obra de Alexander von Humboldt
Authors: Jiménez Pazos Bárbara
Published: December 2017

Es recurrente la tendencia a considerar a Alexander von Humboldt como autor ro-mántico-naturalista, dada la combinación del método científico de análisis empírico de la naturaleza con su visión estético-subjetiva que posee ciertos rasgos “románticos”. Un estudio del léxico empleado por Humboldt en las descripciones de la naturaleza revela, sin embargo, el predominio del lenguaje estrictamente científico e intersubjeti-vo sobre el subjetivo. La presencia de rasgos semánticos “románticos” no es, empero, meramente ornamental, sino que cumple una función estética que, en la percepción humboldtiana de la naturaleza, es un complemento subjetivo indispensable dentro de su imagen holística del mundo.
El significado político de la alegoría de la caverna de Platón
Authors: Zamosc Gabriel
Published: December 2017

El artículo sostiene que la caverna de Platón es fundamentalmente una alegoría política, no epistemológica, y que solo así podremos apreciar la relación que guarda con las imágenes del sol y de la línea. Sobre la base de evidencia textual, se ponen en duda las dos hipótesis principales sobre las que se funda el esfuerzo por encontrar un paralelo epistemológico entre la caverna y la línea: que los prisioneros representan a la humanidad en general, y que la caverna simboliza el mundo visible de la experi-encia corriente, mientras el mundo fuera de esta representa el reino de las ideas. La suspensión de estos supuestos posibilita una lectura que resalta los temas culturales y políticos que están en juego en esta famosa alegoría.
El dilema contractualista
Authors: Vaca Moisés
Published: December 2017

En la ética y la filosofía política contemporáneas es común apelar a alguna for-ma de consenso hipotético para justificar contenidos normativos. En el presente artículo llamo a esta posición “contractualismo” y defiendo tres tesis al respecto. Primera, es correcta la objeción común al contractualismo de que la estipulación de un consenso hipotético en una situación ideal de deliberación no añade nada a la justificación del contenido normativo en cuestión. Segunda, esta objeción da pie a lo que llamo “el dilema contractualista”: cuando hay una situación de des-acuerdo entre dos agentes sobre si un contenido normativo x es correcto, apelar a un acuerdo hipotético en condiciones ideales de deliberación como medio para justificar x, equivale a caer en petición de principio o a establecer una trivialidad. Tercera, a la luz del “dilema contractualista”, el contractualismo no debe ser en-tendido como un método de justificación normativa.
Testimony and crimes against humanity from Hannah Arendt's perspective
Authors: Perrone-Moisés Claudia , Mascaro Laura
Published: December 2017

***Testemunho e crimes contra a humanidade a partir da perspectiva de Hannah Arendt***Considerando a emergência do testemunho como uma fonte privilegiada de história e memória posteriormente à Segunda Guerra Mundial, este artigo pretende discutir o papel do testemunho na teoria de Hannah Arendt, considerando, por um lado, suas críticas à abundância de testemunhos no julgamento de Eichmann e, por outro, a importância que a narrativa, a memória e a metáfora adquirem em sua obra. Essa discussão lança uma luzsobre julgamentos históricos envolvendo crimes contra a humanidade.
Totalitarismo y dictadura: Arendt para leer la historia reciente de Chile
Authors: Merino Maria Jose Lopez
Published: December 2017

***Totalitarismo e ditadura: Arendt para ler a história recente do Chile***Este artigo visa a apresentar e discutir a pertinência ou a impertinência de dois conceitos-chave no pensamento do Hannah Arendt para descrever e compreender processos fundamentais da história recente do Chile: ‘totalitarismo’, como regime fundado no Terror para referir a ditadura de Augusto Pinochet, que teve lugar entre os anos 1973 e 1989, e ‘sociedade de trabalhadores’, como forma pós-totalitária da sociedade de massas, orientada para o trabalho e consumo, para descrever um dos aspectos centrais da sociedade neoliberal que a ditadura chilena instala.
Refugees today: superflousness and humanitarianism
Authors: Jalušič Vlasta
Published: December 2017

***Refugiados hoje: superfluidade e humanitarismo***Este artigo discute algumas questões relativas à abordagem humanitária para “resolver” a chamada crise dos refugiados na Europa no Outono de 2015, quando milhares de refugiados partiram em jornada rumo à UE, a maioria deles para a Alemanha, pela chamada rota migratória dos Balcãs. Quando alguns Estados europeus, como a Eslovênia, começaram a colocar cercas de arame farpado nas suas fronteiras meridionais, os outros retomaram o controle de suas fronteiras internas da UE e quase todos introduziram mais restrições às leis existentes para a proteção internacional de refugiados e asilados. Ao abordar a questão do que é o elemento central do “problema dos refugiados” de hoje, o principal argumento se baseia no conceito de supérfluo de Hannah Arendt como a característica-chave da nova forma de governo global. Há dois lados do fenômeno da superfluidade que são cruciais para entender a situação na qual nos encontramos em relação às assim chamadas “migrações em massa”, o problema de “refugiados”: os “migrantes” e “nós”. Independentemente da necessidade de uma dose de humanitarismo nesses momentos, o foco na “solução” humanitária do problema esconde a questão-chave: como proporcionar, o quanto antes e em longo prazo, que os excluídos das unidades políticas e da lei sejam incluídos (tenham o direito a ter direitos) em uma comunidade política?