bluuebunny/crossref_metadata_2025 huggingface dataset:
‘There isn’t a checklist in the world that’s got that on it’: Special needs teachers’ opinions on the assessment and teaching priorities of pupils on the autism spectrum
Authors: Howell Melanie , Bradshaw Jill , Langdon Peter E
Published: December 2020

Two focus groups were conducted with special needs teachers to: (a) identify barriers to learning for autistic pupils, (b) consider broad assessment domains and specific skills or behaviours which teachers consider important for these pupils, and (c) give their opinions on teacher assessments. Data analysis resulted in six main themes: (a) barriers to learning, (b) teacher priorities for autistic pupils, (c) ways of overcoming barriers, (d) the concept of ‘true mastery’, (e) assessing the bigger picture, and (f) practicalities of assessment. Results showed that teachers have priorities for the pupils they know well and concerns about the assessments they regularly use. To ensure face and content validity of teacher assessments, and for assessments to be useful to and valued by the teachers who use them, it is recommended that teachers have opportunities to input during various aspects of the assessment development process.
Does preservation of columns affect the medium-term outcome in distal humerus hemiarthroplasty for acute unreconstructable fractures?
Authors: Jenkins Christopher W , Edwards Gray AD , Chalk Naomi , McCann Philip A , Amirfeyz Rouin
Published: December 2020

Background

We assessed distal humeral column preservation effects on clinical, radiographic and patient reported outcomes following distal humerus hemiarthroplasty for acute unreconstructable fractures.

Methods

Thirty-seven consecutive patients (mean age, 75; range, 29–93 years) with an average follow-up of 61 months (range, 24–105 months) after distal humerus hemiarthroplasty using a triceps preserving approach were studied. QuickDASH and Oxford Elbow Score assessed patient reported outcomes. Clinical and radiographic assessments comprised range of motion, grip strength, instability, implant loosening, chondral wear, heterotopic ossification and condylar union.

Results

Average QuickDASH was 14.9 (range, 0–63) and Oxford Elbow Score 40.35 (range, 25–48). Mean flexion arc was 108°, extension deficit 17° and pronosupination arc 155°. Average operative sided grip strength was 31.05 kg versus 31.13 kg contralaterally. Column preservation had no statistically significant effect on QuickDASH ( p = 0.75), Oxford Elbow Score ( p = 0.78), flexion–extension ( p = 0.87), pronosupination ( p = 0.78) or grip strength ( p = 0.87). No progressive radiographic loosening or symptomatic chondral wear occurred. All fixed columns united. Three cases of immediate post-operative laxity fully resolved on elbow mobilisation. Four post-operative complications required further surgery: one ulnar neuropathy, one heterotopic ossification, one wound breakdown and one traumatic dislocation.

Conclusion

Medium-term outcome of distal humerus hemiarthroplasty for acute unreconstructable distal humeral fractures is reliable irrespective of condylar preservation.
Verification of administrative data to measure palliative care at terminal hospital stays
Authors: Stubbs Joanne M , Assareh Hassan , Achat Helen M , Greenaway Sally , Muruganantham Poorani
Published: December 2020

Background:

Administrative data and clinician documentation have not been directly compared for reporting palliative care, despite concerns about under-reporting.

Objective:

The aim of this study was to verify the use of routinely collected administrative data for reporting in-hospital palliation and to examine factors associated with coded palliative care in hospital administrative data.

Method:

Hospital administrative data and inpatient palliative care activity documented in medical records were compared for patients dying in hospital between 1 July 2017 and 31 December 2017. Coding of palliative care in administrative data is based on hospital care type coded as “palliative care” and/or assignment of the International Statistical Classification of Diseases and Related Health Problems, Tenth Revision, Australian Modification (ICD-10-AM) palliative care diagnosis code Z51.5. Medical records were searched for specified keywords, which, read in context, indicated a palliative approach to care. The list of keywords (palliative, end of life, comfort care, cease observations, crisis medications, comfort medications, syringe driver, pain or symptom management, no cardiopulmonary resuscitation, advance medical plan/resuscitation plan, deteriorating, agitation, restless and delirium) was developed in consultation with seven local clinicians specialising in palliative care or geriatric medicine.

Results:

Of the 576 patients who died in hospital, 246 were coded as having received palliative care, either solely by the ICD-10-AM diagnosis code Z51.5 (42%) or in combination with a “palliative care” care type (58%). Just over one-third of dying patients had a palliative care specialist involved in their hospital care. Involvement of a palliative care specialist and a cancer diagnosis substantially increased the odds of a Z51.5 code (odds ratio = 11 and 4, respectively). The majority of patients with a “syringe driver” or identified as being at the “end of life” were assigned a Z51.5 code (73.5% and 70.5%, respectively), compared to 53.8% and 54.7%, respectively, for “palliative” or “comfort care.” For each keyword indicating a palliative approach to care, the Z51.5 code was more likely to be assigned if the patient had specialist palliative care input or if they had cancer.

Conclusion:

Our results suggest administrative data under-represented in-hospital palliative care, at least partly due to medical record documentation that failed to meet ICD-10-AM coding criteria. Collaboration between clinicians and coders can enhance the quality of records and, consequently, administrative data.
Primary hyperparathyroidism caused by bilateral parathyroid cystic carcinoma in a cat
Authors: Virtanen Juulia K , Mölsä Sari H , Hagner Karoliina A , Salonen Hanna M , Kilpinen Susanne
Published: December 2020

Case summary

A 16-year-old neutered female Korat cat presented with chronic vomiting, mild azotaemia and mild hypercalcaemia. Physical examination revealed bilateral palpable masses on each side of the trachea. Laboratory results were consistent with primary hyperparathyroidism, diagnostic imaging findings with cystic thyroid or parathyroid masses, and fine-needle aspiration cytology with thyroid hyperplasia or adenoma. In order to confirm whether one or two of the masses were the cause of the hyperparathyroidism, cystic fluid was aspirated from both for parathyroid hormone concentration measurement. The concentration was shown to exceed that of the serum manyfold in both samples, confirming both masses to be functional and of parathyroid origin. A total parathyroidectomy and thyroidectomy were performed on the right side, and a subtotal thyroidectomy and a subtotal to total parathyroidectomy on the left, without any major postoperative complications. Histopathology was consistent with bilateral parathyroid carcinoma.

Relevance and novel information

To our knowledge, this report is the first to describe a rare case of bilateral parathyroid cystic carcinoma in a cat. It highlights the usefulness of determining parathyroid hormone concentration in the cystic fluid of a suspected neoplastic parathyroid mass preoperatively. It also demonstrates that it may be possible to remove most of the cervical parathyroid and thyroid tissue of a cat without causing any clinically relevant hypocalcaemia or iatrogenic hypothyroidism. However, serum concentrations of ionised calcium, thyroxine and creatinine should be closely monitored in the postoperative period in order to detect and control possible complications.
Group Counseling for English Language Learners to Promote Academic Navigational Capital
Authors: Montes Adonay A. , Ramos Erika
Published: December 2020

The purpose of this study was to explore the impact of an 8-week academic navigational capital group with English language learner (ELL) students. Minimal research exists examining ELL students’ acquisition of navigational capital skills (skills needed to navigate and succeed in academic settings) in school. We used a pre- and postintervention survey to measure the impact of the group. Results showed growth in the academic navigational capital skills of all participants. Such increases represent a starting blueprint to consider when working with ELL students.
Early Clinical Result of Computerized Navigated Screw Fixation in Treatment of Fragility Pelvic Fracture
Authors: Ho Sin Yiu , Chuen Siu Yuk , Man Ma Chun
Published: December 2020

Introduction:

Minimal invasive fixation of fragility pelvic fracture is feasible with advancement of computerized navigation. However, the clinical outcomes compared with conservative care were seldom mentioned.

Method:

This is a retrospective study comparing the outcomes of elderly with stable pelvic fracture treated conservatively or operatively using computerized navigation. Outcome parameters included pain score, analgesics requirement, length of hospital stay and complication(s), if any.

Result:

Operations were performed in 15 patients from July 2017 to November 2018. A retrospective cohort of 37 patients who were treated conservatively was recruited. In the operative group, it showed a statistically significant reduction in analgesics consumption at 4-week time only. There was significant improvement in pain score at 1-week, 4-week and 3-month time. Patients showed earlier return to premorbid walking status. No major surgical complication was noted.

Conclusion:

Treating fragility pelvic fracture with computerized navigated screw fixation achieve better pain control, reduction in analgesics requirement and earlier mobilization.
The Origins of the Early Iranian Enlightenment: The Case of Akhundzade’s “Qirītīkā”
Authors: Rezaei Mohammad
Published: December 2020

Akhundzade is one of the greatest Iranian modern intellectuals. Addressing nationalism, literary criticism, and alphabet reform in the Muslim world, and, most importantly, provoking trenchant criticism of the Islamic religion, he initiated a persistent controversy among the Iranian intellectuals. It is often argued that he approached the European thought through the lens of self-orientalism and grounded a so-called will to imitation. Drawing on his method of Qirītīkā (criticism), particularly in Maktūbāt (1865), I argue that he confronted the Western ideas instrumentally and was aware of the historical and social context of Iran. Furthermore, despite his apparent secular approach, which is labelled usually as garbzade (West-struck), he articulated an ensemble of elements that can be traced back to pre-Islamic Iran, India, and the West. His intellectual works not only stand as the figureheads of regional studies but also represent a pathbreaking approach to the problem of backwardness in Muslim societies.
Resilience Role of Distribution Centers amid COVID-19 Crisis in Tier-A Cities of India: A Green Field Analysis Experiment
Authors: Kaur Gurvinder , Pasricha Sudhir , Kathuria Girish
Published: December 2020

Supply chain is the most critical lifeline of all business/non-business operations and processes in today’s world. The outbreak of the COVID-19 epidemic has a serious impact on organizations and society at large. Due to this pandemic spread, food supply chains are facing two unique unraveling emerging supply chain challenges: (a) supply shocks and (b) demand shocks. Stocking of consumer staples under such uncertain situations gives rise to uncertain peak demands of staple food, and hence striking bullwhip effect. The present study focuses on the staple food distribution among tier-A cities of India, namely Bangalore, Hyderabad, Chennai, Pune, Kolkata, Mumbai, and Ahmedabad. Using the software anyLogistix PLE edition, greenfield analysis was conducted to find the number of distribution centers required by these cities for food distribution and to reduce the transportation cost between the cities. Two key insights emerge from the analysis: (a) we need six potential areas to locate distribution centers (DCs)/ regional sites instead of a single DC; (b) transportation cost is reduced from US$21,327 to US$2,375. The major observation from the Green Field Analysis (GFA) reveals there is a need to reinforce and repair the operational efficiencies of DCs so as to reach the needy end consumers.
Evaluation of floor acceleration demands from the 2017 Mexico City code seismic provisions using a continuous elastic model and records of instrumented buildings
Authors: Jaimes Miguel A , García-Soto Adrián D
Published: December 2020

This study presents an evaluation of floor acceleration demands for the design of rigid and flexible acceleration-sensitive nonstructural components in buildings, calculated using the most recent Mexico City seismic design provisions, released in 2017. This evaluation includes two approaches: (1) a simplified continuous elastic model and (2) using recordings from 10 instrumented buildings located in Mexico City. The study found that peak floor elastic acceleration demands imposed on rigid nonstructural components into buildings situated in Mexico City might reach values of 4.8 and 6.4 times the peak ground acceleration at rock and soft sites, respectively. The peak elastic acceleration demands imposed on flexible nonstructural components in all floors, estimated using floor response spectra, might be four times larger than the maximum acceleration of the floor at the point of support of the component for buildings located in rock and soft soil. Comparison of results from the two approaches with the current seismic design provisions revealed that the peak acceleration demands and floor response spectra computed with the current 2017 Mexico City seismic design provisions are, in general, adequate.
Prevalence and outcomes of pulmonary hypertension after percutaneous closure of atrial septal defect: a systematic review and meta-analysis
Authors: Akseer Selai , Horlick Eric , Vishwanath Varnita , Hobbes Benjamin , Huszti Ella , Mak Susanna , Lee Douglas S. , Abrahamyan Lusine
Published: December 2020

Background

Atrial septal defect (ASD) is a common form of congenital heart disease. Significant shunts may increase the risk of developing pulmonary hypertension (PH). We aimed to describe current PH definitions, evaluate PH prevalence and the effect of PH on outcomes in patients undergoing percutaneous ASD closure.

Methods

EMBASE, MEDLINE and Cochrane databases were systematically searched. Studies reporting PH prevalence or mean systolic pulmonary arterial pressure (sPAP) before and after percutaneous ASD closure in adults were included. We conducted meta-analyses to obtain summary estimates for PH prevalence and mean sPAP.

Results

15 articles with a total of 1073 patients met the eligibility criteria. Studies applied variable PH definitions. PH prevalence and mean sPAP levels decreased in all studies after closure. The pooled PH prevalence decreased from 44% (95% CI 29–60%) to 18% (95% CI 8–27%). The overall standardised mean difference in sPAP was 1.12 (95% CI 0.81–1.44) and 1.62 (95% CI 1.00–2.23) in cohort and case-series studies respectively indicating a large decrease. The pooled standard mean difference among the younger and older patients were different, 1.25 (95% CI 0.78–1.71) and 0.91 (95% CI 0.56–1.27), respectively. A high degree of between-study heterogeneity was noted.

Conclusions

Both PH prevalence and mean sPAP decrease after ASD closure. Larger, prospective studies with consistent PH definitions using the recommended measurement modality are warranted.
Current developments and future directions in respiratory physiotherapy
Authors: Rodrigues Antenor , Muñoz Castro Gerard , Jácome Cristina , Langer Daniel , Parry Selina M. , Burtin Chris
Published: December 2020

Respiratory physiotherapists have a key role within the integrated care continuum of patients with respiratory diseases. The current narrative review highlights the profession's diversity, summarises the current evidence and practice, and addresses future research directions in respiratory physiotherapy. Herein, we describe an overview of the areas that respiratory physiotherapists can act in the integrated care of patients with respiratory diseases based on the Harmonised Education in Respiratory Medicine for European Specialists syllabus. In addition, we highlight areas in which further evidence needs to be gathered to confirm the effectiveness of respiratory therapy techniques. Where appropriate, we made recommendations for clinical practice based on current international guidelines.
Early life stress and development: potential mechanisms for adverse outcomes
Authors: Smith Karen E. , Pollak Seth D.
Published: December 2020

Background

Chronic and/or extreme stress in early life, often referred to as early adversity, childhood trauma, or early life stress, has been associated with a wide range of adverse effects on development. However, while early life stress has been linked to negative effects on a number of neural systems, the specific mechanisms through which early life stress influences development and individual differences in children’s outcomes are still not well understood.

Main text

The current paper reviews the existing literature on the neurobiological effects of early life stress and their ties to children’s psychological and behavioral development.

Conclusions

Early life stress has persistent and pervasive effects on prefrontal–hypothalamic–amygdala and dopaminergic circuits that are at least partially mediated by alterations in hypothalamic–pituitary–adrenal axis function. However, to date, this research has primarily utilized methods of assessment that focus solely on children’s event exposures. Incorporating assessment of factors that influence children’s interpretation of stressors, along with stressful events, has the potential to provide further insight into the mechanisms contributing to individual differences in neurodevelopmental effects of early life stress. This can aid in further elucidating specific mechanisms through which these neurobiological changes influence development and contribute to risk for psychopathology and health disorders.
Exploratory spatial analysis of autism rates in New York school districts: role of sociodemographic and language differences
Authors: McGrath Kathleen , Bonuck Karen , Mann Mana
Published: December 2020

Background

Literature on autism spectrum disorder (ASD) suggestslowerASD prevalence andhigherage of diagnosis among children of color, from lower socioeconomic backgrounds, and from families with lower educational levels. These disparities have been attributed to factors such as limited access to diagnostic and treatment services, less opportunity for upward mobility to locales with ample resources, and linguistic barriers. However, few studies describe prevalence and geographic differences of ASD diagnoses by English Language Learner (ELL) status.

Objectives

The primary objectives of this study are to (1) spatially explore the prevalence of ASD among New York State school districts and (2) examine differences of ASD prevalence rates between ELLs and native English-speaking peers.

Methods

Using the 2016–2017 district-level data on public and non-public school age students (3–21 years old) receiving special education services in New York, we analyzed sociodemographic trends among school districts with varying percentages (low, medium, and high ranges) of students with ASD and ELLs. To do this, we conducted exploratory spatial analyses using GIS software, analysis of school district level demographic data, and multivariate linear regression.

Results

In contrast to prior research on ASD prevalence among minority groups, we found disproportionately higher rates of ASD among school districts with higher proportions of Black and Hispanic students. Geographic analysis revealed statistically significant clustering of school districts with high ASD rates in New York City and Albany. Higher proportions of ELLs tended to be concentrated in densely populated, urban, and geographically smaller school districts and had higher proportions of Black, Hispanic, and Asian students.

Conclusions

Schools with higher rates of ASD and ELL students tend to be concentrated in urban regions throughout New York and have higher representation of Black and Hispanic/Latino students, as well as higher rates of learning disabilities in general. Further research is warranted to explore possible reasons for this phenomenon.
Psychosocial deprivation and receptive language ability: a two-sample study
Authors: Humphreys Kathryn L. , Machlin Laura S. , Guyon-Harris Katherine L. , Nelson Charles A. , Fox Nathan A. , Zeanah Charles H.
Published: December 2020

Background

The quality of early caregiving experiences is a known contributor to the quality of the language experiences young children receive. What is unknown is whether, and if so, how psychosocial deprivation early in life is associated with long-lasting receptive language outcomes.

Methods

Two prospective longitudinal studies examining early psychosocial deprivation/neglect in different contexts (i.e., deprivation due to institutional care or deprivation experienced by children residing within US families) and receptive language as assessed via the Peabody Picture Vocabulary Test (PPVT) were used to assess the magnitude of these associations. First, 129 participants from the Bucharest Early Intervention Project, a randomized controlled trial of foster care as an alternative to institutional care in Romania, completed a receptive language assessment at age 18 years. Second, from the USA, 3342 participants from the Fragile Families and Child Wellbeing Study were assessed from infancy until middle childhood.

Results

Children exposed to early institutional care, on average, had lower receptive language scores than their never institutionalized counterparts in late adolescence. While randomization to an early foster care intervention had no long-lasting association with PPVT scores, the duration of childhood exposure to institutional care was negatively associated with receptive language. Psychosocial deprivation in US families was also negatively associated with receptive language longitudinally, and this association remained statistically significant even after accounting for measures of socioeconomic status.

Conclusion

Experiences of psychosocial deprivation may have long-lasting consequences for receptive language ability, extending to age 18 years. Psychosocial deprivation is an important prospective predictor of poorer receptive language.

Trial registration

Bucharest Early Intervention Project ClinicalTrials.gov Identifier: NCT00747396
Epigenetics modifiers: potential hub for understanding and treating neurodevelopmental disorders from hypoxic injury
Authors: Cristancho Ana G. , Marsh Eric D.
Published: December 2020

Background

The fetal brain is adapted to the hypoxic conditions present during normal in utero development. Relatively more hypoxic states, either chronic or acute, are pathologic and can lead to significant long-term neurodevelopmental sequelae. In utero hypoxic injury is associated with neonatal mortality and millions of lives lived with varying degrees of disability.

Main body

Genetic studies of children with neurodevelopmental disease indicate that epigenetic modifiers regulating DNA methylation and histone remodeling are critical for normal brain development. Epigenetic modifiers are also regulated by environmental stimuli, such as hypoxia. Indeed, epigenetic modifiers that are mutated in children with genetic neurodevelopmental diseases are regulated by hypoxia in a number of preclinical models and may be part of the mechanism for the long-term neurodevelopmental sequelae seem in children with hypoxic brain injury. Thus, a comprehensive understanding the role of DNA methylation and histone modifications in hypoxic injury is critical for developing novel strategies to treat children with hypoxic injury.

Conclusions

This review focuses on our current understanding of the intersection between epigenetics, brain development, and hypoxia. Opportunities for the use of epigenetics as biomarkers of neurodevelopmental disease after hypoxic injury and potential clinical epigenetics targets to improve outcomes after injury are also discussed. While there have been many published studies on the epigenetics of hypoxia, more are needed in the developing brain in order to determine which epigenetic pathways may be most important for mitigating the long-term consequences of hypoxic brain injury.
Using DenseFly algorithm for cell searching on massive scRNA-seq datasets
Authors: Chen Yixin , Chen Sijie , Zhang Xuegong
Published: December 2020

Background

High throughput single-cell transcriptomic technology produces massive high-dimensional data, enabling high-resolution cell type definition and identification. To uncover the expressional patterns beneath the big data, a transcriptional landscape searching algorithm at a single-cell level is desirable.

Results

We explored the feasibility of using DenseFly algorithm for cell searching on scRNA-seq data. DenseFly is a locality sensitive hashing algorithm inspired by the fruit fly olfactory system. The experiments indicate that DenseFly outperforms the baseline methods FlyHash and SimHash in classification tasks, and the performance is robust to dropout events and batch effects.

Conclusion

We developed a method for mapping cells across scRNA-seq datasets based on the DenseFly algorithm. It can be an efficient tool for cell atlas searching.
Long-term effects of asthma medication on asthma symptoms: an application of the targeted maximum likelihood estimation
Authors: Veit Carolin , Herrera Ronald , Weinmayr Gudrun , Genuneit Jon , Windstetter Doris , Vogelberg Christian , von Mutius Erika , Nowak Dennis , Radon Katja , Gerlich Jessica , Weinmann Tobias
Published: December 2020

Background

Long-term effectiveness of asthma control medication has been shown in clinical trials but results from observational studies with children and adolescents are lacking. Marginal structural models estimated using targeted maximum likelihood methods are a novel statistiscal approach for such studies as it allows to account for time-varying confounders and time-varying treatment. Therefore, we aimed to calculate the long-term risk of reporting asthma symptoms in relation to control medication use in a real-life setting from childhood to adulthood applying targeted maximum likelihood estimation.

Methods

In the prospective cohort study SOLAR (Study on Occupational Allergy Risks) we followed a German subsample of 121 asthmatic children (9–11 years old) of the ISAAC II cohort (International Study of Asthma and Allergies in Childhood) until the age of 19 to 24. We obtained self-reported questionnaire data on asthma control medication use at baseline (1995–1996) and first follow-up (2002–2003) as well as self-reported asthma symptoms at baseline, first and second follow-up (2007–2009). Three hypothetical treatment scenarios were defined: early sustained intervention, early unsustained intervention and no treatment at all. We performed longitudinal targeted maximum likelihood estimation combined with Super Learner algorithm to estimate the relative risk (RR) to report asthma symptoms at SOLAR I and SOLAR II in relation to the different hypothetical scenarios.

Results

A hypothetical intervention of early sustained treatment was associated with a statistically significant risk increment of asthma symptoms at second follow-up when compared to no treatment at all (RR: 1.51, 95% CI: 1.19–1.83) or early unsustained intervention (RR:1.38, 95% CI: 1.11–1.65).

Conclusions

While we could confirm the tagerted maximum likelihood estimation to be a usable and robust statistical tool, we did not observe a beneficial effect of asthma control medication on asthma symptoms. Because of potential due to the small sample size, lack of data on disease severity and reverse causation our results should, however, be interpreted with caution.
Correction to: Distance learning in clinical medical education amid COVID-19 pandemic in Jordan: current situation, challenges, and perspectives
Authors: Al-Balas Mahmoud , Al-Balas Hasan Ibrahim , Jaber Hatim M. , Obeidat Khaled , Al-Balas Hamzeh , Aborajooh Emad A. , Al-Taher Raed , Al-Balas Bayan
Published: December 2020

An amendment to this paper has been published and can be accessed via the original article.
Use of short message service in at-home COVID-19 patient management
Authors: Loubet Paul , Czeschan Christian , Sintes Matthieu , Sotto Albert , Laureillard Didier
Published: December 2020

Background

Mobile health innovations are well adapted for ambulatory coronavirus disease 2019 (COVID-19) patients who risk clinical deterioration at home during the second week of illness.

Methods

A short message service (SMS) communication program was implemented by French physicians to monitor COVID-19 patients after discharge from outpatient or emergency care. The aim of the SMS tracking is to advise patients about their need for medical reassessment if reporting worsening of COVID-19 symptoms.

A follow-up via SMS to all confirmed positive patients in the Nîmes area (France) was established. Every morning, patients received four follow-up questions. Daily responses were converted to green, orange or red trees, analysed in real time by physicians. “Red” patients were called immediately to check their condition and organise transfer to hospital if needed. “Orange” patients were called within two hours to verify whether the specific instructions following the SMS had been followed.

Results

From March 21 to June 30, 2020, 1007 patients agreed to sign up to the SMS tracking, 62% were women and the mean age was 41.5 years (standard deviation (SD) 16.0). During follow-up, 649 (64%) became “orange” and 69 (7%) “red”. Ten patients were directly admitted to the Infectious Diseases Department during their follow-up due to clinical worsening, all but one as a result of SMS alerts and subsequent telephone assessment by physicians.

Conclusion

SMS tracking platforms could be useful as an early warning system to refer patients with worsening clinical status to hospital-based care or additional clinician advice.
Correction to: Objective understanding of the Nutri-score front-of-pack label by European consumers and its effect on food choices: an online experimental study
Authors: Egnell Manon , Talati Zenobia , Galan Pilar , Andreeva Valentina A. , Vandevijvere Stefanie , Gombaud Marion , Dréano-Trécant Louise , Hercberg Serge , Pettigrew Simone , Julia Chantal
Published: December 2020

An amendment to this paper has been published and can be accessed via the original article.
Lower versus higher hemoglobin threshold for transfusion in ARDS patients with and without ECMO
Authors: Hunsicker O. , Materne L. , Bünger V. , Krannich A. , Balzer F. , Spies C. , Francis R. C. , Weber-Carstens S. , Menk M. , Graw J. A.
Published: December 2020

Background

Efficacy and safety of different hemoglobin thresholds for transfusion of red blood cells (RBCs) in adults with an acute respiratory distress syndrome (ARDS) are unknown. We therefore assessed the effect of two transfusion thresholds on short-term outcome in patients with ARDS.

Methods

Patients who received transfusions of RBCs were identified from a cohort of 1044 ARDS patients. After propensity score matching, patients transfused at a hemoglobin concentration of 8 g/dl or less (lower-threshold) were compared to patients transfused at a hemoglobin concentration of 10 g/dl or less (higher-threshold). The primary endpoint was 28-day mortality. Secondary endpoints included ECMO-free, ventilator-free, sedation-free, and organ dysfunction-free composites.

Measurements and main results

One hundred ninety-two patients were eligible for analysis of the matched cohort. Patients in the lower-threshold group had similar baseline characteristics and hemoglobin levels at ARDS onset but received fewer RBC units and had lower hemoglobin levels compared with the higher-threshold group during the course on the ICU (9.1 [IQR, 8.7–9.7] vs. 10.4 [10–11] g/dl, P < 0.001). There was no difference in 28-day mortality between the lower-threshold group compared with the higher-threshold group (hazard ratio, 0.94 [95%-CI, 0.59–1.48], P = 0.78). Within 28 days, 36.5% (95%-CI, 27.0–46.9) of the patients in the lower-threshold group compared with 39.5% (29.9–50.1) of the patients in the higher-threshold group had died. While there were no differences in ECMO-free, sedation-free, and organ dysfunction-free composites, the chance for successful weaning from mechanical ventilation within 28 days after ARDS onset was lower in the lower-threshold group (subdistribution hazard ratio, 0.36 [95%-CI, 0.15–0.86], P = 0.02).

Conclusions

Transfusion at a hemoglobin concentration of 8 g/dl, as compared with a hemoglobin concentration of 10 g/dl, was not associated with an increase in 28-day mortality in adults with ARDS. However, a transfusion at a hemoglobin concentration of 8 g/dl was associated with a lower chance for successful weaning from the ventilator during the first 28 days after ARDS onset.

Trial Registration: ClinicalTrials.gov NCT03871166.
Correction to: A collaborative care psychosocial intervention to improve late life depression in socioeconomically deprived areas of Guarulhos, Brazil: the PROACTIVE cluster randomised controlled trial protocol
Authors: Scazufca Marcia , Nakamura Carina Akemi , Peters Tim J. , Henrique Maiara Garcia , Seabra Antônio , La Rotta Ehidee Gomez , Franzin Renato M. , Martins Daniele Ferreira , Van de Ven Pepijn , Hollingworth William , Araya Ricardo
Published: December 2020

An amendment to this paper has been published and can be accessed via the original article.
Low iron mitigates viral survival: insights from evolution, genetics, and pandemics—a review of current hypothesis
Authors: Menshawey Rahma , Menshawey Esraa , Alserr Ayman H. K. , Abdelmassih Antoine Fakhry
Published: December 2020

Background

Upon re-examination of our human history, evolutionary perspectives, and genetics, a prevailing iron deficiency phenotype appears to have evolved to protect the human race from extinction.

Body

In this review, we summarize the evolutionary and genetic perspectives pointing towards the hypothesis that low iron mitigates infection. The presence of infection promotes the generation of resistance alleles, and there are some evolutionary and genetic clues that suggest the presence of an iron deficiency phenotype that may have developed to protect against infection. Examples include the relative paucity of iron overload genes given the essential role of iron, as well as the persistence of iron deficiency among populations in spite of public health efforts to treat it. Additional examination of geographic areas with severe iron deficiency in the setting of pandemics including H1N1, SARS, and COVID-19 reveals that areas with higher prevalence of iron deficiency are less affected. RNA viruses have several evolutionary adaptations which suggest their absolute need for iron, and this dependency may be exploited during treatment.

Conclusion

RNA viruses pose a unique challenge to modern healthcare, with an average of 2–3 new pathogens being discovered yearly. Their overarching requirements for iron, along with human evolutionary and genetic adaptations which favored an iron deficiency phenotype, ultimately suggest the potential need for iron control in these infections.
Proper Care of Transgender and Gender Diverse Persons in the Setting of Proposed Discrimination: A Policy Perspective*
Authors: Walch Abby , Davidge-Pitts Caroline , Safer Joshua D , Lopez Ximena , Tangpricha Vin , Iwamoto Sean J
Published: December 2020

Transgender and gender diverse (TGD) individuals face significant barriers to accessing health care. Recent introductions of regulatory policies at state and federal levels raise concerns over the politicization of gender-affirming health care, the risks of further restricting access to quality care, and the potential criminalization of healthcare professionals who care for TGD patients. The Endocrine Society and the Pediatric Endocrine Society have published several news articles and comments in the last couple of years supporting safe and effective gender-affirming interventions as outlined in the 2017 Endocrine Society’s Clinical Practice Guidelines. The Endocrine Society Position Statement on Transgender Health also acknowledges the rapid expansion in understanding the biological underpinning of gender identity and the need for increased funding to help close gaps in knowledge about the optimal care of TGD individuals. This Policy Perspective affirms these principles in the context of pending and future legislation attempting to discriminate against TGD patients while also stressing the need for science and health care experts to inform health policies.
Satellite cell expansion is mediated by P-eIF2α dependent Tacc3 translation
Authors: Fujita Ryo , Jamet Solène , Lean Graham , Cheng Harry Chun Man , Hébert Steven , Kleinman Claudia L. , Crist Colin
Published: December 2020

Translational control of gene expression is an important regulator of adult stem cell quiescence, activation and self-renewal. In skeletal muscle, quiescent satellite cells maintain low levels of protein synthesis, mediated in part through the phosphorylation of eIF2α (P-eIF2α). Pharmacological inhibition of the eIF2α phosphatase with the small molecule sal003 maintains P-eIF2α and permits the expansion of satellite cells ex vivo. Paradoxically, P-eIF2α also increases the translation of specific mRNAs, which is mediated by P-eIF2α dependent readthrough of inhibitory upstream open reading frames (uORFs). Here, we ask whether P-eIF2α dependent mRNA translation enables expansion of satellite cells. Using transcriptomic and proteomic analyses, we show a number of genes associated with the assembly of the spindle pole to be upregulated at the level of protein, without corresponding change in mRNA levels, in satellite cells expanded in the presence of sal003. We show that uORFs in the 5'UTR of mRNA for the mitotic spindle stability gene Tacc3 direct P-eIF2α dependent translation. Satellite cells deficient for TACC3 exhibit defects in expansion, self-renewal and regeneration of skeletal muscle.
Androgen action in cell fate and communication during prostate development at single-cell resolution
Authors: Lee Dong-Hoon , Olson Adam W. , Wang Jinhui , Kim Won Kyung , Mi Jiaqi , Zeng Hong , Le Vien , Aldahl Joseph , Hiroto Alex , Wu Xiwei , Sun Zijie
Published: December 2020

Androgens/androgen receptor (AR) mediated signaling pathways are essential for prostate development, morphogenesis, and regeneration. Specifically, stromal AR-signaling has been shown to be essential for prostatic initiation. However, the molecular mechanisms underlying AR-initiated mesenchymal-epithelial interactions in prostate development remain unclear. Here, using a newly generated mouse model, we directly addressed the fate and role of genetically marked AR-expressing cells during embryonic prostate development. Androgen signaling-initiated signaling pathways were identified in mesenchymal niche populations at single cell transcriptomic resolution. The dynamic cell-signaling networks regulated by stromal AR were characterized in regulating prostatic epithelial bud formation. Pseudotime analyses further revealed the differentiation trajectory and fate of AR-expressing cells in both prostatic mesenchymal and epithelial cell populations. Specifically, the cellular properties of Zeb1-expressing progenitors were assessed. Selective deletion of AR signaling in a subpopulation mesenchymal rather than epithelial cells dysregulates the expression of the master regulators and significantly impairs prostatic bud formation. These data provide novel, high-resolution evidence demonstrating the important role of mesenchymal androgen signaling as cellular niches controlling prostate early development by initiating dynamic mesenchyme-epithelia cell interactions.
Loss of ESRP1 blocks mouse oocyte development and leads to female infertility
Authors: Yu Luping , Zhang Huiru , Guan Xuebing , Qin Dongdong , Zhou Jian , Wu Xin
Published: December 2020

Alternative splicing (AS) contributes to gene diversification, but AS program during germline development remains largely undefined. Here, we interrupted pre-mRNA splicing events controlled by epithelial splicing regulatory protein 1 (ESRP1) and found that it induced female infertility in mice. Esrp1 deletion perturbed spindle organization, chromosome alignment, and metaphase-to-anaphase transformation in oocytes. The first polar body extrusion (PBE) was blocked during oocyte meiosis due to abnormal activation of spindle assembly checkpoint (SAC) and insufficiency of anaphase-promoting complex/cyclosome (APC/C) in Esrp1-knockout oocytes. Esrp1-knockout hampered follicular development and ovulation; eventually, premature ovarian failure (POF) occurred in six-month-old Esrp1-knockout mouse. Using single-cell RNA sequencing analysis, 528 aberrant AS events of maternal mRNA transcripts were revealed and were preferentially associated with microtubule cytoskeletal organization. Notably, we found that loss of ESRP1 disturbed a comprehensive set of gene-splicing sites—including those within Trb53bp1, Rac1, Bora, Kif2c, Kif23, Ndel1, Kif3a, Cenpa, and Lsm14b—that potentially caused abnormal spindle organization. Collectively, our findings provide the first report elucidating the ESRP1- mediated AS program of maternal mRNA transcripts, may contribute to oocyte meiosis and female fertility in mice.
The protein tyrosine phosphatase PTP-PEST mediates hypoxia-induced endothelial autophagy and angiogenesis via AMPK activation
Authors: Chandel Shivam , Manikandan Amrutha , Mehta Nikunj , Nathan Abel Arul , Tiwari Rakesh Kumar , Mohapatra Samar Bhallabha , Chandran Mahesh , Jaleel Abdul , Manoj Narayanan , Dixit Madhulika
Published: December 2020

Global and endothelial loss of PTP-PEST (also known as PTPN12) is associated with impaired cardiovascular development and embryonic lethality. Although hypoxia is implicated in vascular remodelling and angiogenesis, its effect on PTP-PEST remains unexplored. Here we report that hypoxia (1% oxygen) increases protein levels and catalytic activity of PTP-PEST in primary endothelial cells. Immunoprecipitation followed by mass spectrometry revealed that α subunits of AMPK (α1 and α2, encoded by PRKAA1 and PRKAA2, respectively) interact with PTP-PEST under normoxia but not in hypoxia. Co-immunoprecipitation experiments confirmed this observation and determined that AMPK α subunits interact with the catalytic domain of PTP-PEST. Knockdown of PTP-PEST abrogated hypoxia-mediated tyrosine dephosphorylation and activation of AMPK (Thr172 phosphorylation). Absence of PTP-PEST also blocked hypoxia-induced autophagy (LC3 degradation and puncta formation), which was rescued by the AMPK activator metformin (500 µM). Because endothelial autophagy is a prerequisite for angiogenesis, knockdown of PTP-PEST also attenuated endothelial cell migration and capillary tube formation, with autophagy inducer rapamycin (200 nM) rescuing angiogenesis. In conclusion, this work identifies for the first time that PTP-PEST is a regulator of hypoxia-induced AMPK activation and endothelial autophagy to promote angiogenesis.
Programmed Dynamic Covalent Chemistry System of Addition-condensation Reaction of Phenols and Aldehydes
Authors: Kudo Hiroto , Shimoyama Daisuke , Sekiya Ryo , Haino Takeharu
Published: December 2020

Application of a dynamic covalent chemistry strategy to the reversible reaction system of resorcinol and α, ω-alkanedials [(CH2)m(CHO)2] (m = 2–10) in ethanol in the presence of hydrogen chloride (HCl) solution as a catalyst at 80 °C for 48 h afforded the thermodynamically most stable products with high selectivity. The reaction of 1,4-butanedial afforded a ladder polymer containing calixarene skeletons in the main chain in quantitative yield. 1,5-Pentanedial gave Noria, a water-wheel-like cyclic oligomer, in high yield. Calixarene-dimer-type cyclic oligomers were formed selectively from 1,6-hexanedial, 1,8-octanedial, 1,10-decanedial, and 1,12-dodecanedial, while calixarene-trimer-type cyclic oligomers were obtained selectively from 1,7-heptanedial, 1,9-nonanedial, and 1,11-undecanedial. The Noria like macrocyles NoriaPY NoriaMP and NoriaEP could be also synthesized via DCC using pyrogallol, 3-methoxyphenol, and 3-ethoxyphenol. A triple-ringed[14]arene could be synthesized via DCC using the reaction of 2-methylresorcinol and m-benzenedicarbaldehyde.
Analysis of the value-motivational sphere of employees of internal affairs bodies in the forecast of the success of professional adaptation
Authors: Goncharova Natal'ya , Popinako Ekaterina
Published: December 2020

The article discusses the results of an empirical study of the value-motivational sphere of employees of internal affairs bodies, which allow predicting the success of professional adaptation. A comparison of the indicators of groups of adapted and non-adapted individuals revealed a fundamentally different level of personal adaptive potential, communicative potential, behavioral regulation and moral level. It has been established that the value-motivational profile of employees with a high level of personal adaptive potential is represented by higher indicators of internal motivation, values of service to society, normative behavior and professional achievements. In the field of socio-psychological adaptability, these are indicators of moral normativeness and the ability to constructive communication, in the motivational sphere - an orientation to success and achievement. The features of the value consciousness of a successfully adapted personality are established, expressed in the priorities of serving society, moral and business value orientation and professionalism.
Human factors in home healthcare: challenges and recommendations
Authors: Sheppy Bruce , Itua Imose , McIntosh Bryan
Published: December 2020

With home care methods and devices becoming an increasingly important part of healthcare, this article discusses how a human factors approach can ensure a just working culture while also providing optimal patient care.
Anti-neutrophil cytoplasmic antibodies-associated vasculitis: a guide and case study
Authors: Boyer Helena , Mortimore Gerri
Published: December 2020

Vasculitis is a relatively rare and poorly understood condition causing inflammation of the blood vessels, which in turn can affect a patient's respiratory and renal systems. In some cases, ocular involvement can cause loss of sight and hearing loss may also be a red flag for vasculitis, which, if not treated early, can cause complete hearing loss. Anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) is a group comprising granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) and eosinophilic granulomatosis (EGP). AAV is fatal if untreated and as increased risk escalates with age, coupled with a decline in renal function, these are the principal predictors of poor outcome. Vital roles for nursing vasculitis patients lie in managing inflammation and pain, as these distressing symptoms are prevalent in the disease. Because of the multiple complications that can occur with vasculitis, treatment-related information is a high priority for these patients. As nurses are well placed to deliver information, value lies in their role in reducing the negative impacts on treatment regimens and compliance that accompany patients' poor insight into their condition.
Stoma care: procedures, appliances and nursing considerations
Authors: Hill Barry
Published: December 2020

Several diseases and operations may necessitate the need for the formation of a stoma. Patients who are affected may be concerned about the effect of the stoma on their ability to carry out activities of daily living, as well as how it will affect their quality of life. Nurses who may be involved in the care of patients with a stoma should have an understanding of the reasons for stoma formation, and the types of stoma and appliances available, to enable them educate and support patients, and to allay any concerns.