bluuebunny/crossref_metadata_2025 huggingface dataset:
El periodismo deportivo peruano en internet: un análisis del sensacionalismo y el humor en el programa web A presión en el contexto del repechaje del Mundial Qatar 2022
Authors:   , Alomía Díaz Rodrigo Martín
Published: May 2024

La presente investigación analiza el uso de los recursos sensacionalistas y humorísticos del periodismo deportivo peruano de internet en el caso específico del programa web A presión. Al respecto, la pandemia del COVID-19 trajo consigo una serie de cambios significativos en los medios de comunicación. El aumento de la audiencia en línea, producto de la cuarentena obligatoria a nivel global, generó que las transmisiones en vivo a través de plataformas como Twitch o YouTube crecieran exponencialmente. Programas televisivos consolidados empezaron a adoptar parrillas exclusivas para estas plataformas, como El chiringuito de jugones, uno de los espacios deportivos más vistos de España. En Perú, el caso de A presión destaca por tratarse de un programa deportivo eminentemente digital e independiente que, pese a que no tiene más de tres años de antigüedad, suma más 90 millones de vistas en YouTube. Comprender el uso de los recursos sensacionalistas y humorísticos de A presión, en el contexto del repechaje del Mundial Qatar 2022 y el papel de la selección peruana de fútbol, es la razón de ser de esta investigación. Así, en las siguientes páginas se explorará una relación que no es nueva: la del periodismo deportivo con el sensacionalismo y el humor, pero en este caso inmersa en un contexto digital. Una aproximación histórica y teórica de esta relación abrirá paso al análisis de contenido de diez programas de A presión, lo cual contribuirá a identificar cómo la magnificación de noticias o el uso de fórmulas humorísticas, por citar algunos ejemplos, los ha consolidado en tan corto tiempo.
Artes plásticas e estratégias de disseminação de jogos e brincadeiras tradicionais
Authors: Schwartz Gisele Maria , Teodoro Ana Paula Evaristo Guizarde
Published: May 2024

Objetivo: apontar as contribuições das artes plásticas na disseminação dos jogos e brincadeiras tradicionais, com base em pinturas de artistas nacionais, e sugerir estratégias de releitura e ressignificação para difundi-los no contexto da Educação Física. Metodologia: O estudo teve uma natureza qualitativa e foi desenvolvido por meio de pesquisas bibliográfica e exploratória, realizada em sites constantes do portal de buscas Google, aplicando-se os descritores relativos a pinturas de jogos tradicionais e pinturas de crianças brincando. Resultados e discussão: A amostra intencional foi composta pelas obras de 05 pintores brasileiros, famosos por retratarem cenas de crianças em dinâmicas de expressão da ludicidade, focalizando jogos e brincadeiras tradicionais. Foram sugeridas estratégias de releitura dessas obras, a partir de jogos sensitivo-expressivos e da produção de histórias em quadrinhos. Conclusão: Os dados analisados descritivamente ressaltam que, esse conteúdo pautado nas artes plásticas, atividades expressivas e quadrinhos, pode favorecer subsídio adequado para aquisição e difusão de conhecimento sobre jogos tradicionais, sobretudo no contexto da Educação Física.
Los desechos del canon
Authors: Fernandez Juan Manuel
Published: May 2024

En los ensayos de Paul Groussac publicados en La Biblioteca, sobre todo en “La educación por el folletín” (1897), se hace manifiesta una inquietud del canon crítico argentino frente a una producción literaria a la que se concibe como basura, en plena proliferación y dirigida a una población a la que se piensa también como un desecho social. En un abordaje de la recepción contemporánea de Zola por parte de jóvenes escritores profesionales, Groussac impugna, primeramente, una literatura del escritor militante, dirigida al gran público, en la que resuena el conflicto social que involucra a los obreros y al lumpen. La crítica al folletín supone también una respuesta conservadora frente a tendencias políticas y estéticas modernas que considera disolventes, en defensa de un concepto de sociedad apolíneo, centrado en la familia, coherente con los principios civilizatorios, científico-sociales y morales, de la latinidad y la cristiandad. Sus producciones críticas y literarias dialogan también con los discursos gubernamentales y con las tesis crepusculares de la psiquiatría contemporánea. En ellas puede hallarse una oscilación entre un rol higienista, que distingue lo saludable de lo patológico en las artes y las ciencias, y una experimentación o asimilación de esta producción literaria destinada al excedente social, que lo posiciona, inesperadamente, como escritor de literatura folletinesca.  
Groussac publicados en La biblioteca, sobre todo en “La educación por el folletín” (1897), se hace manifiesta una inquietud del canon crítico argentino frente a una producción literaria a la que se concibe como basura, en plena proliferación y dirigida a una población a la que se piensa también como un desecho social. En un abordaje de la recepción contemporánea de Zola por parte de jóvenes escritores profesionales, Groussac impugna, primeramente, una literatura del escritor militante, dirigida al gran público, en la que resuena el conflicto social que involucra a los obreros y al lumpen. La crítica al folletín supone también una respuesta conservadora frente a tendencias políticas y estéticas modernas que considera disolventes, en defensa de un concepto de sociedad apolíneo, centrado en la familia, coherente con los principios civilizatorios, científico-sociales y morales, de la latinidad y la cristiandad. Sus producciones críticas y literarias dialogan también con los discursos gubernamentales y con las tesis crepusculares de la psiquiatría contemporánea. En ellas puede hallarse una oscilación entre un rol higienista, que distingue lo saludable de lo patológico en las artes y las ciencias, y una experimentación o asimilación de esta producción literaria destinada al excedente social, que lo posiciona, inesperadamente, como escritor de literatura folletinesca.
A inconstância da forma selvagem
Authors: Rosa Victor Luiz da
Published: May 2024

Desde sua primeira publicação em 1931 até a morte de Raul Bopp, em 1984, Cobra Norato foi apresentado em oito diferentes versões. Quando se compara essas versões, logo se percebe que as alterações feitas pelo poeta foram contínuas, às vezes profundas e, mais do que isso, se relacionam de diferentes maneiras com a própria natureza do poema. Por outro lado, a crítica em torno de Cobra Norato, se já nas primeiras resenhas logo reconheceu a existência dessas alterações, jamais buscou compreender a sua natureza e as possíveis consequências desse singular procedimento. A partir de um comentário de Drummond, publicado em 1947, até as reflexões mais recentes sobre o poema, esse caráter metamórfico de Cobra Norato foi negligenciado ou diminuído, em privilégio sempre de uma única edição, tomada sempre como definitiva. O presente artigo, se não tem a ambição de fazer uma análise detalhada de todas as versões do poema, se propõe a especular sobre algumas das causas e dos efeitos dessas transformações, assim como discutir aspectos da singularidade do procedimento de Bopp. E defender a hipótese de que as contínuas alterações feitas pelo poeta são o princípio formal que potencializa as metamorfoses do poema, que também troca de pele como a própria cobra do mito.
Apresentação
Authors: Durão Fabio Akcelrud , Berriel Carlos Eduardo Ornelas
Published: May 2024

O setor de artigos avulsos deste número traz um material de relevância para o Departamento de Teoria Literária do IEL-Unicamp: os três documentos do título de Professor Emérito concedido a Roberto Schwarz. Esse pedido foi uma iniciativa de professores do Departamento, confirmada por vários outros intelectuais, apontando a imensa contribuição de sua obra para as ciências humanas em geral e, em particular, para os estudos literários, além da sua atuação na crítica literária e no debate público que tanto promoveu o nome da Unicamp nos âmbitos nacional e internacional. O pedido foi aprovado unanimemente no Departamento de Teoria Literária, no Instituto de Estudos da Linguagem e no Conselho Universitário da Unicamp.
DIALOG SEBAGAI METODE PEMBELAJARAN: STUDI KITAB AL-TARBIYYAH BI AL-HIWAR KARYA ABDURRAHMAN AN-NAHLAWI
Authors: Alwan Muharir , Izzati Himayatul
Published: May 2024

Islamic theology has a very large educational role in shaping the civilization of a society. However, Islamic Education today is in a dilemmatic position, between Rationalist-Critical or remaining in a position of strengthening religious theology. This article is a literature review that focuses on the theorizing of an-Nahlawi's work. By using content analysis on an-Nahlawi's main work, At-Tarbiyah bi al-Hiwar: Min Asalib at-Tarbiyah al-Islamiyah, as well as conducting a comparative analysis with another an-Nahlawi's work, Ushul at-Tarbiyah al-Islamiyah wa Asalibuha fi al-Bayt wa al-Madrasah wa al-Mujtama'. This research found several conclusions: (a) Kitab at-tarbiyah bi al-Hiwar is a study of Islamic education methods which were inspired by the educational journey undertaken by Allah to his Prophets, as well as that carried out by the Prophet Muhammad to his Companions. (b) Hiwar is an Islamic-Qur'anic terminology used in the communication of Allah to His Servant. The al-Hiwar method is the authentic method of Islam even from the beginning of the Revelation of the Qur'an. (c) The method of education with hiwar has been explained in detail in the Qur'an and the history of Islamic teaching by the Prophet Muhammad to his people, including: Hiwar Qur'ani and Nabawi, Hiwar Washfi, Hiwar Khitabi -Ta'abbudi and Hiwar at-ta 'lim. Islamic education is the transmission of knowledge and the transformation of a good soul and can provide goodness in life.
ATSARU HARFATI AL-MUDARRIS ‘ALA RAGHBATI AL-THALABATI FII TA’ALLUMI AL-LUGHATI AL-‘ARABIYYATI
Authors: Fitrah Isti Jayang , Hakim Abdul , Jihad Salimul , Abidin Munirul , Rahmawati Baiq Laili
Published: May 2024

This study aims to determine the effect of teacher’s professionalism on student’s interest in Arabic learning of class X MAN 1 Mataram for academic year 2020/2021. The population in this study were students of class X MAN 1 Mataram and the researcher took 45 students from the population to be used as samples in this study. The research approach used is quantitative research because the desired data is in the form of numbers. The researcher used three research instruments for collecting data namely questionnaires, documentation and observation. The data analysis used Pearson product moment correlation and simple regression with the help of SPSS 16.0 software. Based on the results of the correlation analysis, there was a positive and significant relationship with a correlation level of R=67% indicating a strong relationship between the two variables. And as for the results of the regression analysis, the researcher got the value of F arithmetic > F table 37.140> 4.06 with a significance level of 0.00 <0.05 so it can be concluded that there is an effect of teacher professionalism (X) on students' interest in learning Arabic (Y), with the contribution of the effect of teacher’s professionalism (X) on students' interest in learning (Y) is R Square = 45.8%. Therefore, the hypothesis which says "teacher’s professionalism effect on student’s interest in Arabic learning of class X MAN 1 Mataram for academic year 2020/2021 " is accepted
TATWIR WASIILATU TA’LIIMI ALMUFRODAAT ‘ALA DHOUI ANDROID BISTIKHDAAMI KODULAR LITALAAMIZI ALMADROSATI ALIBTIDAIYYATI ALMUHAMMADIYYATI JOPANG MANGANTI
Authors: Rahmad Muhammad , Salam M. Yusuf , Suharmon Suharmon , Harahap Partomuan
Published: May 2024

The main problem in this research is the lack of use of learning media which results in students' lack of attention to Arabic language learning. This research aims to (1) find out what students' needs are for Android-based Arabic vocabulary learning media using codular (2) find out the validity of the learning media developed; and (3) knowing the practicality of the learning media being developed. This research is research and development by adapting the 4-D model, namely define, design, development, disseminate. The research instruments used were interview sheet instruments, validation sheets, and practicality sheets. The data analysis technique used is descriptive statistical analysis. The results of this research are android-based Arabic vocabulary learning media for Arabic language lessons at Muhammadiyah Fullday Jopang Manganti Elementary School, especially for class III. This learning media consists of five discussions, each discussion consisting of mufradat, images, sounds, and exercises to support student learning. The research results show that (1) the average results show that students need Android-based Arabic vocabulary learning media using Kodular to support Arabic language learning in class III with a percentage of 100%. (2) the results of research validation analysis by three validators obtained an average learning media validation of 3.92 with a very valid category. (3) the results of trials conducted on 17 students and 1 Arabic language teacher also obtained results with an average score of 3.92 in the very practical category
Characteristics of Nonunion Fractures in Patients with Antebrachial Fractures at dr. Mohamad Soewandhie General Hospital Surabaya 2021-2022: A Retrospective Study
Authors: Monica Tasya , Sasono Bimo , Sekarputri Cempaka Harsa
Published: May 2024

Background: Nonunion, a complication of fracture healing, can lead to patient morbidity. Contributing factors include age, gender, fracture type, multiple fractures, infection, prolonged nonsteroidal anti-inflammatory drug (NSAID) use, smoking, nutritional status, and history of chronic disease. This study aims to determine the prevalence and characteristics of nonunion antebrachial fractures at dr. Mohamad Soewandhie General Hospital Surabaya.
Methods: This retrospective descriptive study involved 111 patients. Data was gathered from medical records treated at dr. Mohamad Soewandhie General Hospital Surabaya for antebrachial fracture during 2021-2022. The study protocol obtained approvals from two local ethical committees. Data included demographics, fracture characteristics, fracture type, multiple fractures, infection, NSAID use, hypertension and diabetes history, smoking habits, and nutritional status by BMI calculation.
Results: This study found a 24.3% prevalence of antebrachial nonunion fractures at dr. Mohamad Soewandhie General Hospital Surabaya in 2021-2022, mostly in males (66.7%) aged 17-25 years (22.2%). Nonunion in antebrachial fractures is marked by high rates in closed (92.6%) and single fractures (92.6%). Notably, infections (22.2%), smoking (7.4%), and hypertension history (7.4%) are common contributors. Despite ideal BMI in many cases (44.4%), nonunion still occurred.
Conclusions: The study conducted at Dr. Mohamad Soewandhie General Hospital in Surabaya revealed a high prevalence of antebrachial nonunion fractures at 24.3%, particularly among young males. It was found that closed, single fractures were the most common type, with infections, smoking, and a history of hypertension being significant contributing factors. Interestingly, even individuals with an ideal BMI were still at risk for nonunion.
To what extent are wastewater treatment systems a gateway for microplastic particles in the aquatic and terrestrial environments?
Authors: Gomiero Alessio , Øysæd Kjell Birger , Jaén-Gil Adrián , Navrestad Veslemøy , Skogerbø Geir
Published: May 2024

Sewage treatment plants are designed to handle wastes that include several types of pollutants, including microplastics (MPs), which are synthetic polymer materials fragmented to sizes < 5 mm. Investigating the abundance and removal efficiency rates of MPs in wastewater treatment plants is important because the water body to which plant effluents are discharged may be adversely affected by the released MPs. Therefore, the abundance, characteristics, and removal of MPs at two sewage treatment plants located on the southwest coast of Norway are studied. Twenty-four samples were collected across two sampling sessions by using an ad hoc-designed plastic-free water sampling device, which was improved by applying a cascade of certified stainless-steel sieves. A combined sequence of enzymatic and strong oxidative incubations was performed for sample preparation. The obtained samples were chemically characterized and quantified using thermoanalytical techniques. The overall amounts of polymers in the inlet wastewater and outlet water were 366-616 μg/L and 34-57 μg/L, respectively, indicating an approximate MPs removal efficiency of 78%-85%. Polyethylene (≈ 36%-68%), polypropylene (≈ 7%-48%), polystyrene (≈ 5%-6%), polyvinyl chloride (≈ 15%-26%), polyamide (≈ 2%), polymethacrylate (≈ 3%-4%), polycarbonate (≈ 2%), and polyethylene terephthalate (≈ 9%-32%) were detected in the investigated samples. In biosolids, the overall quantity of MPs was 3.8-5.5 mg/g dry weight across the two investigated sewage treatment plants. Polyethylene (≈ 24%-44%), followed by polyvinyl chloride (PVC) (≈ 11%-16%), and polyamide (≈ 2%-22%) were the most commonly recurring polymer types. The outcomes of this study indicate that MPs are removed efficiently from wastewaters. However, large amounts of MPs accumulate in biosolids. Therefore, sludge dumping management procedures need to be improved to lower the amount of MPs released into the environment through effluents and biosolids.
Comprehensive understanding of glioblastoma molecular phenotypes: classification, characteristics, and transition
Authors: Xu Can , Hou Pengyu , Li Xiang , Xiao Menglin , Zhang Ziqi , Li Ziru , Xu Jianglong , Liu Guoming , Tan Yanli , Fang Chuan
Published: May 2024

Among central nervous system-associated malignancies, glioblastoma (GBM) is the most common and has the highest mortality rate. The high heterogeneity of GBM cell types and the complex tumor microenvironment frequently lead to tumor recurrence and sudden relapse in patients treated with temozolomide. In precision medicine, research on GBM treatment is increasingly focusing on molecular subtyping to precisely characterize the cellular and molecular heterogeneity, as well as the refractory nature of GBM toward therapy. Deep understanding of the different molecular expression patterns of GBM subtypes is critical. Researchers have recently proposed tetra fractional or tripartite methods for detecting GBM molecular subtypes. The various molecular subtypes of GBM show significant differences in gene expression patterns and biological behaviors. These subtypes also exhibit high plasticity in their regulatory pathways, oncogene expression, tumor microenvironment alterations, and differential responses to standard therapy. Herein, we summarize the current molecular typing scheme of GBM and the major molecular/genetic characteristics of each subtype. Furthermore, we review the mesenchymal transition mechanisms of GBM under various regulators.
Design of a New Digital Cognitive Screening Tool on Tablet: AlzVR Project
Authors: Maronnat Florian , Loup Guillaume , Degand Jonathan , Davesne Frederic , Otmane Samir
Published: May 2024

Introduction: Alzheimer's disease (AD) is the first cause of dementia worldwide without any current curative treatment. Facing an increasing prevalence and its associated costs, AD represents a public health challenge. Usual diagnostic methods still rely on extended interviews and paper tests provided by an exterior examiner. We aim to create a novel, quick cognitive-screening tool on a numerical tablet. Methods: This program, built and edited with Unity®, runs on Android® for the Samsung Galaxy Tab S7 FE®. Composed of seven tasks inspired by the Mini-Mental Status Examination and the Montréal Cognitive Assessment, it browses several cognitive functions. The architectural design of this tablet application is distinguished by its multifaceted capabilities, encompassing not only seamless offline functionality but also a mechanism to ensure the singularity of data amalgamated from diverse sites. Additionally, a paramount emphasis is placed on safeguarding the confidentiality of patient information in the healthcare domain. Furthermore, the application empowers individual site managers to access and peruse specific datasets, enhancing their operational efficacy and decision-making processes. We performed a preliminary usability assessment among healthy subjects. Results: 24 healthy patients were included with a final F-SUS score of "excellent". Participants perceived the tool as simple to use and achieved the test in a mean time of 142 seconds. No technical errors occurred. Conclusion: These preliminary results suggest that our new assessment on a numerical tablet allows a short cognitive screening.
Micro and Macroscopic Analysis of Fatigue Wear of Gear Wheel Top Layer – an Impact Analysis of Thermochemical Treatment
Authors: Osiński Piotr , Dudziński Włodzimierz , Deptuła Adam , Łuszczyna Rafał , Kalita Marek
Published: May 2024

The main purpose of this work was to tests of form and size of fatigue wear of the top layer of oil gear pump wheel (3PW-BPF-24). The object of tests was operated during a determined number of hours at strictly controlled operational and environmental parameters. A microscope of focal differentiation by Alicona InfiniteFocus G4 (with Focus-Variation optical measuring technology) was used for an identification, measurement and description of noticed superficial defects, which resulted from the fatigue process of the top layer and an earlier thermochemical treatment. The work was finished with an analysis of obtained results (based on the analysis of 3D scans) and conclusions concerning about optimization of the thermal treatment. Taking into consideration the presented results (suggestions) in the technology of improving strength properties of gear wheels (of this type oil pumps) may render it possible to obtain an appropriate fatigue endurance of the top layer, i.e. a minimization of observed superficial defects.
Time-Optimal Motions of Mechanical System with Viscous Friction
Authors: Kamzolkin Dmitrii , Ternovski Vladimir
Published: May 2024

Optimal control is a critical tool for mechanical robotic systems, facilitating precise manipulation of dynamic processes. These processes are described through differential equations governed by a control function, addressing a time-optimal problem with bilinear characteristics. Our study utilizes the classical approach complemented by Pontryagin's Maximum Principle (PMP) to explore this inverse optimal problem. The objective is to develop an exact piecewise control function that effectively manages trajectory control while considering the effects of viscous friction. Our simulations demonstrate that the proposed control law markedly diminishes oscillations induced by boundary conditions. This research not only aims to delineate the reachability set but also strives to determine the minimal time required for the process. The findings include an exact analytical solution for the stated control problem.
Intravesical Gemcitabine and Docetaxel Therapy for BCG-Naïve Patients: a Promising Approach in Non-Muscle Invasive Bladder Cancer
Authors: Bakula Mirko , Hudolin Tvrtko , Knezevic Nikola , Zimak Zoran , Andelic Jerko , Juric Ilija , Gamulin Marija , Gnjidic Milena , Kastelan Zeljko
Published: May 2024

Bacillus Calmette-Guérin (BCG) therapy for patients with non-muscle invasive bladder cancer (NMIBC) faces limitations in efficacy and significant side effects, aggravated by a recent global shortage. In this prospective clinical study, we report outcomes of sequential intravesical adminis-tration of gemcitabine and docetaxel (Gem/Doce) as the first-line treatment in BCG-naïve patients with high-risk NMIBC (HR NMIBC). From October 2019 until April 2022, we enrolled 52 patients and followed treatment protocol set by the University of Iowa. Follow-up assessments were con-ducted every 3 months. In this cohort, 25 (48.1%) patients were diagnosed with T1HG bladder cancer, 10 (19.2%) patients had carcinoma in situ (CIS), and 17 (32.7%) patients had a combination of CIS+T1HG. Median time to first recurrence in T1HG, CIS and T1HG+CIS groups was 11, 10.5 and 8.8 months, respectively. The recurrence-free survival was 98.1%, 94.2% and 80.8% at 6, 9 and 12 months, respectively. The rate of progression-free survival was 100%, 98.1% and 92.3% at 6, 9 and 12 months, respectively. We demonstrated the safety and efficacy of Gem/Doce therapy in BCG-naïve patients with HR NMIBC during a one-year follow-up. Further research with extended follow-up, as well as direct comparison of Gem/Doce and other anticancer agents, are essential.
The Novel Impact of Augmented Reality and 3D Printing in the Diagnosis of Complex Acetabular Fractures: A Comparative Randomized Study in Orthopedic Residents
Authors: Montemagno Marco , Testa Gianluca , Panvini Flora Maria Chiara , Puglisi Gianluca , Papotto Giacomo , Marchese Emanuele , Pavone Vito
Published: May 2024

Augmented Reality (AR) and 3D printing (3DP) are novel technologies in the orthopedic field. Over the past decade, enthusiasm for these new digital applications is driving new perspectives in improving diagnostic accuracy and sensitivity in the field of traumatology. Currently, however, it is still difficult to quantify the value and impact in the medical-scientific field especially in the improvement of diagnostic in complex fractures. Acetabulum fractures have always been a challenge among orthopedics, for volumetric complexity and low diagnostic reliability.Background/Objectives: The goal of this study is to determine whether these methods can improve the learning aspect and diagnostic accuracy of complex acetabulum fractures compared to gold standard CT (computed tomography). Methods: Orthopedic residents of our department have been selected and divided into Junior (JUN) and Senior (SEN) groups. Associated fractures of acetabulum have been included in the study, obtaining : CT-scans, 3DP model, and AR model displayed on a tablet screen. In a double-blind questionnaire, each resident classified every fracture according to methods. Diagnostic accuracy (DA), response time (RT), agreement (R), and confidence (C) were measured. Results: 20 residents (JUN=10, SEN=10) classified five fractures. Overall DAs were 26% (CT), 18% (3DP), and 29% (AR). AR-DA resulted to be superior to 3DP-DA (p=0,04). DA means (JUN vs SEN respectively) were :CT-DA was 20% vs 32% (p<0.05), 3DP-DA was 12% vs 24% (p=0.08), and AR-DA was 28% vs 30% (p=0,80). Overall RT was 61.2 sec (±24,6) for CT, 35.8 sec (±20,1) for 3DP, and 46,7 sec (±20,8) for AR. R was fairly poor between methods and groups. 3DPs resulted to have superior overall C (65%). Conclusions: AR resulted to have the same Overall DA as CT, independent from experience, 3DP has minor DA and R, but it resulted to be the most confident and fast method. Intra and interobserver R between methods remain very poor in residents.
Validation of modified electrode surfaces as Sensitive Analytical Tools in Soil Analysis; Detection of Total Concentration of Zn (II), Cd(II), Pb(II), Cu(II)/Cu (I) along with Handling Complicated Sample Matrices
Authors: Keramari Vasiliki , Papadimou Sotiria , Golia Evangelia E. , Girousi Stella
Published: May 2024

Heavy metals constitute pollutants particularly common in air, water, and soil. They are present in both urban and rural environments, on land and in marine ecosystems, causing serious environmental problems since they do not degrade easily, remain almost unchanged for long periods, and bioaccumulate. Detection, though especially quantification, is a systematic process as monitoring of their levels needs to be carried out at regular intervals since there is often seasonal variation. The need for rapid and low-cost determination of metals is therefore considerable. In the present study atomic absorption spectroscopy (AAS), using a flame or graphite furnace, and square wave anodic stripping voltammetry (SWASV), using a bismuth thin film electrode, a sensitive voltammetric method is being compared and analytically validated. Atomic absorption spectroscopy (AAS) represents a well-established analytical technique while anodic stripping voltammetry is being criticized for its applicability in complicated sample matrices such as soil samples. This sample-handling challenge is being investigated in the present study. The results show that both methods AAS and ASV were satisfactorily correlated and showed that the concentration of metals is lower than the limit values, but with increasing trend. Therefore, continuous monitoring of metal levels in the urban complex of the city is necessary and a matter of great importance. Regarding Cd, the detection limits of Cd are lower compared to those of AAS when using the graphite furnace, while an overestimation was noted when using flame-AAS in comparison with those found with SWASV. The SWASV method has the advantage of being cheaper and faster, enabling the simultaneous determination of heavy elements across the range of concentrations that these elements can occur in Mediterranean soils. Additionally, we applied a dsDNA-modified electrode which can be used in the speciation analysis of Cu(I) and Cu(II). The changes in the characteristic peaks of guanine and adenine can be applied in the redox speciation analysis of copper in soil which represents an issue of great importance.
Understanding Semantic User Interactions in Visualization
Authors: Jeong Dong Hyun , Jeong Bong Keun , Ji Soo Yeon
Published: May 2024

In the field of visualization, understanding users’ analytical process is important to determine the effectiveness of a designed visualization application. To understand the users’ analytical process, numerous studies have been performed to capture and analyze user interactions. Although many studies have emphasized the importance of analyzing user interactions to understand users’ analytical reasoning processes, few have successfully linked these interactions to users’ reasoning processes. This paper introduces an approach that bridges this gap by correlating semantic user interactions with analysis decisions through an interactive wire transaction analysis system and a visual state transition matrix. With the designed analysis system, interactive analysis can be performed to evaluate financial fraud in wire transactions. It also allows the mapping of captured user interactions and analytical decisions back onto the visualization, revealing users’ distinct results. The visual state transition matrix further aids to help understanding users’ analytical flows, revealing their decision-making processes. Classification machine learning algorithms are applied to assess the effectiveness of our approach in understanding analysts’ strategies by connecting them to their decisions. From the study, we observed an average of 72% accuracy in clearly classifying the semantic user interactions. For classifying individual decisions, we observed an average of 70% classification accuracy. This emphasizes the importance of capturing semantic user interactions to understand users’ analytical processes. Overall, it is determined that the proposed approach not only enhances the understanding of analytical behaviors but also offers a robust approach for evaluating user interactions in visualization tools.
Exorbital Lacrimal Gland Ablation and Regrafting Induce Local, Corneal and Trigeminal Ganglion Inflammation but Not Regeneration or Dry Eye
Authors: Murashima Adriana de Andrade Batista , Sant'Anna Ariane M. S. , Faustino-Barros Jacqueline Ferreira , Machado Filho Elisio B. , da Silva Lilian Costa Mendes , Fantucci Marina Zilio , Módulo Carolina Maria , Chahud Fernando , Garcia Denny Marcos , Rocha Eduardo M.
Published: May 2024

The study evaluated the regenerative responses of the lacrimal functional unit (LFU) after Lacrimal Gland (LG) ablation. The LG of Wistar rats were submitted to G1) partial LG ablation, G2) partial ablation and transplantation of an allogeneic LG, or G3) total LG ablation, (n=7-10/group). The eye wipe test, slit-lamp image, tear flow, and histology were evaluated. RT-PCR analyzed inflammatory and proliferation mediators. The findings were compared to naïve controls after 1 and 2 months (M1 and M2). G3 presented increased corneal sensitivity, and the 03 groups have shown corneal neovascularization. Histology revealed changes in LG, and corneal inflammation. In the LG, there was an increase in MMP-9 mRNA of G1 and G2 at M1 and M2 and RUNX-1 at M1 and M2 in G1 and RUNX-3 mRNA at M1 in G1, and in G2 at M2. TNF-α mRNA rose in the corneas of G1 and G2 at M2. There was an increase in the IL-1β mRNA in the Trigeminal Ganglion of G1 at M1. Without changes in tear flow or evidence of LG regeneration, LG ablation or grafting are unreliable models for dry eye or LG repair in rats. The surgical manipulation extended inflammation to the LFU.
Hepatitis C Virus Dysregulates Polyamine and Proline Metabolism and Perturbs Urea Cycle
Authors: Zakirova Natalia F. , Khomich Olga A. , Smirnova Olga A. , Molle Jennifer , Duponchel Sarah , Yanvarev Dmitry V. , Valuev-Elliston Vladimir T. , Monnier Lea , Grigorov Boyan , Ivanova Olga N. , Karpenko Inna L. , Golikov Mikhail V. , Bovet Cedric , Rindlisbacher Barbara , Khomutov Alex R. , Kochetkov Sergey N. , Bartosch Birke , Ivanov Alexander V.
Published: May 2024

Hepatitis C virus (HCV) is an oncogenic virus that causes chronic liver disease in more than 80% of patients. During the last decade, efficient direct acting antivirals were introduced into clinical practice. However, clearance of the virus does not reduce risk of end-stage liver diseases to the level observed in patients that have never been infected. So, investigation of HCV pathogenesis is still warranted. Virus-induced changes in cell metabolism contribute to the development of HCV-associated liver pathologies. Here we studied the impact of the virus on the metabolism of polyamines and proline as well as on the urea cycle, which plays a crucial role in liver function. It was found that HCV strongly suppresses the expression of arginase, a key enzyme of the urea cycle, leading to accumulation of arginine and upregulates proline oxidase with a concomitant decrease in proline concentrations. Addition of exogenous proline moderately suppressed viral replication. HCV upregulated transcription but suppressed protein levels of polyamine-metabolizing enzymes. This resulted in a decrease in polyamine content in infected cells. Finally, compounds targeting polyamine metabolism demonstrated pronounced antiviral activity pointing to spermine and spermidine as compounds affecting HCV replication. These data expand our understanding of HCV’s imprint on cell metabolism.
Identification and Discrimination of Petrol Sources by Nuclear Magnetic Resonance Spectroscopy and Machine Learning in Fire Debris Analysis
Authors: Yankova Yanita Yankova , Cirstea Silvia , Cole Michael , Warren John
Published: May 2024

Abstract: Petrol is considered the most common fire accelerant. However, the identification and classification of petrol sources through the years has been proven to be a challenging field in the investigation of fire debris analysis. This research explored the possibility of identifying petrol sources by high field NMR methods accompanied by ML (Machine Learning). The automated identification and classification of petrol brands were achieved for first time based on the ML clas-sification model developed in this research. A hierarchical classification model was constructed using local classifiers to categorize neat or weathered petrol into its sources.
Call to Establish Public Policy for Regulating the Congestion in Delivery Rooms in Israel - Alternatives, Consequences, and Recommendations
Authors: Cohen Erez
Published: May 2024

The growing congestion in delivery rooms and maternity wards in Israeli hospitals is the underlying issue of the current study. The study sought to examine various alternatives for an effective public policy aimed at reducing congestion. The choice of Israel as a case study derives from its conspicuous imbalance between supply and demand in the maternity, resulting from the high demand for prenatal and birthing services on one hand and the low supply, both in absolute terms and relative to OECD countries, of medical resources such as physicians, nurses, and hospital beds. The research findings present fertility and birth data for Israel in the last decade, which are leading to increased congestion and crowding in delivery rooms and maternity wards at local hospitals. At the same time, two possible alternatives are proposed for designing and implementing public policy capable of contributing to the regulation of this congestion. One alternative is the option of home birth and the second is promoting the establishment of private birthing centers outside the hospitals. The research conclusions indicate that policy makers in Israel must anticipate the increasing congestion in hospital delivery rooms and maternity wards and expedite efforts at designing alternative solutions before the emergence of a crisis situation that will make it essential to identify immediate solutions. The study recommends exploring and advancing the adoption of the two alternatives simultaneously as part of public policy, in the assumption that the increasing demand for pregnancy and childbirth services in Israeli society will persist and therefore it is necessary to act to increase the supply of childbirth facilities.
Water Recuperation from Regolith at Martian, Lunar & Micro-gravity during Parabolic Flight
Authors: Farina Dario , Machrafi Hatim , Queeckers Patrick , Minetti Christophe , Iorio Carlo Saverio
Published: May 2024

Recent discoveries of potential ice particles and ice-cemented regolith on celestial bodies like the Moon and Mars have ushered in new opportunities for developing technologies to extract water, facilitating future space missions and activities on these celestial surfaces. This study delves into the potential for water extraction from regolith through an experiment designed to test water recuperation from regolith simulant under varying gravitational conditions. The resultant water vapor extracted from the regolith is re-condensed on a substrate surface and collected in liquid form. Three types of substrates, hydrophobic, hydrophilic, and grooved, are explored. The system’s functionality was assessed during a parabolic flight campaign simulating three distinct gravity levels: microgravity, lunar gravity, and Martian gravity. Our findings reveal that the hydrophobic surface demonstrates the highest efficiency due to drop-wise condensation, and lower gravity levels result in increased water condensation on the substrates. This experiment aims to provide insights into in-situ water recovery, which is pivotal for establishing economically-sustainable water supplies for future missions.
A Novel 3D Reconstruction Sensor Using a Diving Lamp and a Camera for Underwater Cave Exploration
Authors: Massone Quentin , Druon Sebastien , Triboulet Jean
Published: May 2024

Aquifer karstic structures, due to their complex nature, present significant challenges in accurately mapping their intricate features. Traditional methods often rely on invasive techniques or sophisticated equipment, limiting accessibility and feasibility. In this paper, we propose a new approach to non-invasive, low-cost 3D reconstruction using a camera that observes the light projection of a simple diving lamp. Our method capitalizes on the principles of structured light, leveraging the projection of light contours onto the karstic surfaces. By capturing the resultant light patterns with a camera, we reconstruct three-dimensional representations of the structures. The simplicity and portability of the equipment required make this method highly versatile, enabling deployment in diverse underwater environments. We validate our approach through extensive field experiments conducted in various aquifer karstic settings. The results demonstrate the efficacy of our method in accurately delineating intricate karstic features with remarkable detail and resolution. Furthermore, the non-destructive nature of this technique minimizes disturbance to delicate aquatic ecosystems while providing valuable insights into the subterranean landscape. This innovative methodology not only offers a cost-effective and non-invasive means of mapping aquifer karstic structures but also opens avenues for comprehensive environmental monitoring and resource management. Its potential applications span hydrogeological studies, environmental conservation efforts, and sustainable water resource management in karstic terrains worldwide.
Viral Targets in Human Interactome with Comprehensive Centrality Analysis: SARS-CoV-2, A Case Study
Authors: Kumar Nilesh , Mukhtar M. Shahid
Published: May 2024

Network centrality analyses have proven successful in identifying important nodes in diverse host-pathogen interactomes. The current study presents a comprehensive investigation of the human interactome and SARS-CoV-2 host targets. We first constructed a comprehensive human interactome by compiling experimentally validated protein-protein interactions (PPIs) from eight distinct sources. Additionally, we compiled a comprehensive list of 1,449 SARS-CoV-2 host proteins and analyzed their interactions within the human interactome, which identified enriched biological processes and pathways. Seven diverse topological features were employed to reveal the enrichment of SARS-CoV-2 targets in the human interactome, with Load centrality emerging as the most effective metric. Furthermore, a novel approach called CentralityCosDist was employed to predict SARS-CoV-2 targets, which proved effective in expanding the pool of predicted targets. Pathway enrichment analyses further elucidated the functional roles and potential mechanisms associated with predicted targets. Overall, this study provides valuable insights into the complex interplay between SARS-CoV-2 and the host cellular machinery, contributing to a deeper understanding of viral infection and immune response modulation.
The “Galenic Question”: A solution Based on Historical Sources and Mathematical Analysis of Texts
Authors: La Greca Fernando , De Caro Liberato , Matricciani Emilio
Published: May 2024

How many different writers authored the huge number of texts attributed to Galen of Pergamum (129~216 AD), medical doctor and philosopher, a giant in the history of medicine? To find out which texts were his and which ones were written by others is known as the “Galenic Question”. We propose a “solution” to it through a multidisciplinary approach based: (a) on historical research and (b) on a mathematical analysis of the Greek texts. The historical approach has considered historical independent sources and anachronisms. The mathematical approach has been based on a mathematical theory concerning deep–language variables, rarely consciously controlled by any author, therefore capable of giving indications on similarity of texts, with little or no bias. The multidisciplinary approach has convinced us that at least three authors wrote the texts attributed to Galen. The first two very likely were real historical persons: (a) a certain Galen living between the end of the I century BC and the second half of the I century AD; (b) the historical Galen of Pergamum (II–III centuries AD) and (c) several unknown authors hiding under the name Galen, but surely living after Galen of Pergamum’s death.
GPU-Based Acceleration of Metaphor-less Algorithms and Their Application for Solving Large Systems of Nonlinear Equations
Authors: Silva Bruno , Lopes Luiz Guerreiro
Published: May 2024

Traditional population-based metaheuristic algorithms are effective in solving complex real-world problems but require careful strategy selection and parameter tuning. Parameter-less population-based optimization algorithms have gained importance due to their simplicity and efficiency. However, research on their applicability for solving large systems of nonlinear equations is still incipient. In this paper, a systematic review and detailed description of metaphor-less optimization algorithms is made, including the Jaya algorithm, the main Jaya variants for continuous optimization problems, with a focus on the Enhanced Jaya (EJAYA) algorithm, the three Rao algorithms, the best-worst-play (BWP) algorithm, and the very recent max-min-greedy-interaction (MaGI) algorithm. This paper also discusses a few previous parallelizations of the Jaya optimization algorithm, as well as recent GPU-based massively parallel implementations of the Jaya, Enhanced Jaya (EJAYA), Rao, and BWP algorithms developed by the authors. In addition, a novel GPU-accelerated version of the MaGI algorithm is proposed. The GPU-accelerated versions of the metaphor-less algorithms developed by the authors were implemented using the Julia programming language and tested primarily on GeForce RTX 3090 and NVIDIA A100 GPUs, as well as on Tesla V100S and Tesla T4 GPUs, using a set of difficult, large-scale nonlinear equation system problems. The computational experiments carried out produced quite significant speedups, which highlights the efficiency of the GPU-based versions of the metaphor-less algorithms developed for solving large-scale systems of nonlinear equations.
Calcineurin Inhibitors in Atopic Dermatitis
Authors: Janagond Ajit B , Inamadar Arun C
Published: May 2024

Atopic dermatitis (AD) is a chronic inflammatory condition which significantly affects quality of life in both patients and their caregivers. Calcineurin inhibitors (CNI) are a class of immunosuppressive drugs predominantly inhibiting T cell mediated immune processes. CNI form complex by binding with immunophilins and in turn inhibit calcineurin and suppress downstream inflammatory pathway. Tacrolimus and pimecrolimus are topical CNI approved for the treatment of mild to severe AD in both children and adults. Application site reactions are frequently seen. They have been issued with black box warning towards increased risk of malignancies but supportive evidence is lacking. Cyclosporine, though highly effective, is used off-label for AD management. It is used for controlling acute flares of AD due to its very rapid onset of action. Nephrotoxicity and hypertension are its serious complications. CNI have not been reported with teratogenicity and may be used conditionally during pregnancy and lactation.
Past and Future Impacts of the Relative Sea Level Rise on the Seafront of Ancient Delos (Cyclades, Greece) and Flooding Scenarios by 2150
Authors: Mourtzas Nikos , Kolaiti Eleni
Published: May 2024

Sea level rise due to global warming is a continuing and, disappointingly, accelerating process, which has already affected and will further impact coastal lowlands and the social and economic activities in these areas. Delos Island, situated in the middle of the Cyclades in the Aegean Sea, was considered the most sacred of all islands in ancient Greek culture and a trading hub for the entire eastern Mediterranean. Uninhabited since the 7th century AD, and consistently the focus of research and touristic attention, the island is designated as an archaeological site and inscribed on the Unesco World Heritage List. Previous studies on the relative sea level (rsl) changes suggest a steadily rsl rise during the last 6,300 years, starting from a sea level at -4.80±0.20m in the Late Neolithic. The seafront of the ancient city of Delos is subject to the effects of the rsl rise, which have caused significant coastline retreat and exposure to the northerly winds and waves, whereas parts of the coastal lowland where the remains of the ancient city lie are inundated, forming extended wetlands. The future impacts of rsl rise on the seafront of ancient Delos are illustrated on very high-resolution digital surface models, evaluating both the flooding risk under different climatic projections, as provided by the IPCC AR6 report, and the ongoing land subsidence, as recorded by GNSS data. An rsl rise ranging from 87cm (SSP1-2.6 scenario) to 148cm (SSP5-8.5 scenario) is anticipated by 2150, requiring both resilience strategies and adaptation solutions as well as mitigation policies to cope with the effects of climate change.