bluuebunny/crossref_metadata_2025 huggingface dataset:
Allopurinol reverses mercaptopurine-induced hypoglycemia in patients with acute lymphoblastic leukemia
Authors: Zhang Melissa , Bostrom Bruce
Published: February 2019

Fasting hypoglycemia is a known complication of mercaptopurine (6MP) maintenance therapy for acute lymphoblastic leukemia (ALL). It is associated with high levels of the methylated metabolite 6-methyl-mercaptopurine (6MMP). Symptoms of hypoglycemia include morning tremulousness, nausea and vomiting. We have previously shown that switching 6MP dosing from evening to morning resolved hypoglycemia by reducing 6MMP; however, the reduction of 6MMP was only transient, potentially resulting in return of hypoglycemia. In children and adults with Crohn’s disease, co-prescribing allopurinol with 6MP blocks the activity of thiopurine methytransferase (TPMT), reducing 6MMP and improving its tolerance. As a consequence of inhibiting TPMT, 6MP is shunted toward the production of 6-thioguanine nucleotide (6TGN), which will result in pancytopenia if the dose of 6MP is not reduced. We demonstrate that allopurinol with a reduced dose of 6MP in two patients with ALL and 6MMP-associated hypoglycemia resulted in a complete and sustained suppression of 6MMP and rapid reversal of hypoglycemia and its symptoms.
Conclusion of energy service contracts in the field of procurement for state and municipal needs
Authors: Матвеева Елена , Matveeva Elena
Published: February 2019

Monografiya predstavlyayet soboy rabotu, posvyashchennuyu aktual'nym voprosam pravovogo regulirovaniya energoservisnykh dogovorov v kontraktnoy sisteme. V rabote proanalizirovany problemy pravovoy reglamentatsii stadii zaklyucheniya energoservisnykh kontraktov i dany predlozheniya po optimizatsii deystvuyushchikh norm prava.
Monografiya prednaznachena dlya studentov i aspirantov vuzov, a takzhe mozhet predstavlyat' interes dlya organov gosudarstvennogo i munitsipal'nogo upravleniya pri realizatsii meropriyatiy energosberezheniya s ispol'zovaniyem konstruktsii energoservisnogo kontrakta.
The monograph is a work devoted to topical issues of legal regulation of energy service contracts in the contract system. The paper analyzes the problems of the legal regulation of the stage of conclusion of energy service contracts and offers suggestions for optimizing existing legal norms.
The monograph is intended for undergraduate and graduate students of universities, and may also be of interest to state and municipal authorities in the implementation of energy saving measures using the design of an energy service contract.
Proces boloński – pomiędzy oczekiwaniem i środowiskowym rozczarowaniem?
Authors: Szewior Krzysztof
Published: February 2019

The Bologna Process – Between Expectation and Academic Disappointment?The article is an attempt to understand changes in European higher education over the last two decades and to describe them from the perspective of public policies and europeanization processes. This approach was reflected in the development of the OMC and the EHEA. They are the background for the Bologna process. The article attempts to prove that the Bologna Process – in the optics of political science – is an instrument for realizing the values and objectives of European policies, that they are building the European educational and scientific space as one of many EU internal markets.
Traktat lizboński i jego implikacje dla francusko-niemieckiej współpracy w obszarze Wspólnej Polityki Bezpieczeństwa i Obrony Unii Europejskiej
Authors: Paterek Anna
Published: February 2019

The Lisbon Treaty and Its Implications for French‑German Cooperation in EU’s Common Security and Defence PolicyFaced with internal and external pressures the EU’s security and defence policy has become one of the most dynamic fields of European integration. This paper describes declared ambition of Franco‑Germancooperation to strengthening the EU in European security and defence. In light of a more demanding security environment Berlin and Paris have awakened the so‑called „Sleeping Beauty of the Lisbon Treaty”, The Permanent Structured Cooperation (PESCO), introduced by the 2009 Lisbon Treaty. They managed to find a compromise and to turn PESCO into a process as much as to create a new framework to deepen defence cooperation amongst EU Member States. The conclusions argue that the relaunch of the Franco‑German motor is key to European defence.
Interkulturowość zabawy. Obce wzory kultury zabawy i rozrywki i ich recepcja we współczesnej kulturze ludycznej Krakowa
Authors: Kantor Ryszard
Published: February 2019

Interculturality of Play: Foreign Patterns of Entertainment and Play and Their Reception in Ludic Culture of CracowThe article characterizes in anthropological manner new festivals, celebrations, games and plays, which have gained popularity in Cracow in last decade. By speaking of Saint Patric’s Day and Valentine’s Day celebrations or to new local teams playing lacrosse and curling, author tracks diffusion of foreign cultural patterns and their reception. The analysis proves that next to universalizing processes, one can find many examples of adaptation of universal patterns into local cultural environment accomplished by adding unique content and meanings.
OS MEMES COMO AUXÍLIO NA LEITURA MULTIMODAL CRÍTICA: UM RELATO DOCENTE NA SALA DE AULA DE LÍNGUA ESPANHOLA
Authors: Santos Debora Sandyla Araújo
Published: February 2019

Este artigo é baseado em um relato de experiência docente, em que tivemos a pretensão de estimular a criticidade leitora dos alunos adolescentes da rede privada de ensino da região metropolitana de Fortaleza, capital cearense. O referencial teórico é pautado nos eixos conceituais: linguagem online (BARTON; LEE, 2013) letramento multimodal (MOITA LOPES, 2013); multimodalidade e multiletramentos (ROJO, 2012) e leitura crítica (CASSANY, 2006). Dessa forma, almejamos escrever como se dão as análises críticas dos textos multimodais do gênero meme, em língua espanhola, por parte dos alunos do 3º ano do ensino médio, na construção de sentidos, a partir da perspectiva da literatura multimodal crítica online. Diante do exposto, acreditamos que os usos críticos do discurso devem estar presentes nas práticas discursivas da escola, a fim de conscientizar os alunos a uma leitura cidadã mais ativa na sociedade.
Studi Eksperimen Mengenai Metode Baca Good Reading
Authors: Prijana Prijana , Rohman Asep Saeful
Published: February 2019

Penelitian ini dilakukan dengan tujuan untuk mengetahui korelasi kegiatan membaca teks ilmu pengetahuan menggunakan metode good reading dan Penilaian Acuan Patokan (PAP) dengan prestasi akademik mahasiswa. Prestasi akademik mahasiswa menggunakan ketentuan indeks prestasi kumulatif (IPK). Metode yang digunakan dalam penelitian ini adalah kuantitatif dan metode observasi menggunakan studi eksperimen. Partisipan dalam penelitian ini adalah mahasiswa Program Studi Ilmu Perpustakaan Fakultas Ilmu Komunikasi Universitas Padjadjaran, dengan kelompok eksperimen (N=34), dan kelompok kontrol (N=44). Hasil penelitian menunjukkan bahwa prestasi akademik mahasiswa yang diklasifikasikan rendah, sedang, dan tinggi, memiliki hubungan significant dengan metode baca good reading. Prestasi akademik yang diklasifikasikan menggunakan metode PAP (Penilaian Acuan Patokan), memiliki hubungan significant dengan metode baca good reading. Dapat dikatakan bahwa metode PAP lebih cocok digunakan untuk mengklasifikasi prestasi akademik mahasiswa. Metode baca good reading memiliki kepercayaan lebih tinggi dibandingkan dengan metode reading habit jika dikaitkan dengan prestasi akademik mahasiswa.
Jan Hellwig (1931-2000)
Authors: Jamrożek Wiesław
Published: February 2019

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Henryk Sławiński, Wychowanie prorodzinne według pedagogów katolickich Drugiej Rzeczypospolitej, Wyd. Fundacja Pomocy Antyk „Wydawnictwo Antyk - Marcin Dybowski”, Warszawa 2000
Authors: Pacyno Jan
Published: February 2019

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Kongresy i zjazdy pedagogiczne w Polsce. Konferencja naukowa w Olsztynie w dniach 18-20 września 2000 r.
Authors: Jamrożek Wiesław
Published: February 2019

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XXI Seminarium Mediewistyczne pt. Książka na pograniczu chrześcijaństwa wschodniego i zachodniego (X-XVI w.), Poznań 12-14 października 2000
Authors: Ratajczak Krzysztof
Published: February 2019

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Wizerunek matki prezentowany przez Klementynę z Tańskich Hoffmanową na łamach pisma „Rozrywki dla dzieci”
Authors: Karłowska Grażyna
Published: February 2019

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Zdzisław Dąbrowski, Franciszek Kulpiński, Pedagogika opiekuńcza - historia, teoria, terminologia, Olsztyn 2000, Wydawnictwo Uniwersytetu Warmińsko-Mazurskiego, ss. 118
Authors: Sobków Anna
Published: February 2019

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Danuta Koźmian, Janusz Jędrzejewicz polityk i pedagog (1885-1951), Wydawnictwo Naukowe Uniwersytetu Szczecińskiego, Szczecin 2004, s. 171
Authors: Głowacka-Sobiech Edyta
Published: February 2019

Danuta Koźmian, Janusz Jędrzejewicz polityk i pedagog (1885-1951), Wydawnictwo Naukowe Uniwersytetu Szczecińskiego, Szczecin 2004, s. 171
Opowiadanie historii w niemieckiej refleksji teoretyczno- historycznej i literaturoznawczej od oświecenia do współczesności, wybór, przekład i opracowanie Jerzy Kałążny, Wydawnictwo Poznańskie, Poznań 2003, s. 660
Authors: Głowacka-Sobiech Edyta
Published: February 2019

Opowiadanie historii w niemieckiej refleksji teoretyczno-historycznej i literaturoznawczej od oświecenia do współczesności, wybór, przekład i opracowanie Jerzy Kałążny, Wydawnictwo Poznańskie, Poznań 2003, s. 660
Hominem ąuaerere. Człowiek w źródle historycznym, Jugowice, 26-29 maja 2004 r. Ad fontes. Interdyscyplinarne spotkania historyczne
Authors: Ratajczak Krzysztof
Published: February 2019

Hominem ąuaerere. Człowiek w źródle historycznym, Jugowice, 26-29 maja 2004 r. Ad fontes. Interdyscyplinarne spotkania historyczne
V Ogólnopolski Zjazd Peadgogiczny Polskiego Towarzystwa Pedagogicznego (Wrocław, 23-25 września 2004)
Authors: Jamrożek Wiesław
Published: February 2019

V Ogólnopolski Zjazd Peadgogiczny Polskiego Towarzystwa Pedagogicznego (Wrocław, 23-25 września 2004)
Międzynarodowa Konferencja Studenckich Kół Naukowych - Siedlce 23-24 września 2003 r.
Authors: Laskowska Barbara
Published: February 2019

Międzynarodowa Konferencja Studenckich Kół Naukowych - Siedlce 23-24 września 2003 r.
Wątek kształcenia dziewcząt w reformach szkolnych od czasów Komisji Edukacji Narodowej do II wojny światowej
Authors: Dormus Katarzyna
Published: February 2019

Girls’ education as an element of school reforms from the Commission of National Education up to WWIIAt the end of the 18th century and during the partitions, the education of young females constituted a separate educational track. At elementary level, young females had access to regular schools. At secondary level, private and monastic schools dominated. The government’s first interference with the education of young females was, perhaps, the attempt by the Commission of National Education to establish the permanent supervision of certain female schools (under legislation from 1775). The laws regarding education in each partition were not commensurate with the growing educational aspirations of women and the general socio-economic conditions. The Russian Partition was characterised by the dual existence of Polish private schools and governmental schools focused on the Russification of young Polish females. In Galicia, the most controversial issue was the creation of female secondary schools, the  ompletion of which would enable a young woman to pursue university studies. Only during the Second Polish Republic did female education achieve equality before the law.
Wiktor Dega – wybitny lekarz i pedagog (1896–1995) – wspomnienie w dwudziestą rocznicę śmierci
Authors: Apanel Anna Maria , Kotarski Piotr
Published: February 2019

Wiktor Dega – a remarkable medical doctor and educator (1896–1995) – reminiscences on the 20th anniversary of his deathThis elaboration concerns reminiscences on a remarkable human being, medical doctor – an orthopaedist and educator – Wiktor Dega. It consists of two fundamental parts: a biographical part and the other showing the professor’s role in treating and developing a medical care for a child with motor dysfunction. It also presents Wiktor Dega’s academic and didactic activity and his efforts in arranging the first free of charge courses in orthopaedic gymnastics in Poznań primary schools for children with poor posture. This activity was deeply rooted in the professor’s interest in rehabilitation. Wiktor Dega was a co-founder and the first president of the Polish Association for Combating Disability [Towarzystwo do Walki z Kalectwem]. He was a member of the Executive Board of the Polish Academy of Sciences, a member of the Scientific Council at the Ministry of Health and Social Care, an expert for rehabilitation at the WHO and one of advisers of the World Health Fund in New York. For many years he was also a national rehabilitation specialist, the president of the Polish Orthopaedic and Traumatology Association as well as chief editor of the magazine called “Chirurgia Narządów Ruchu i Ortopedii Polskiej”. He was also an honorary citizen of Poznań.
Household borrowing constraints and monetary policy in emerging economies
Authors: Arruda Gustavo , Lima Daniela , Teles Vladimir Kühl
Published: February 2019

Credit markets in emerging economies can be distinguished from those in advanced economies in many respects, including the collateral required for households to borrow. This work proposes a DSGE framework to analyze one peculiarity that characterizes the credit markets of some emerging markets: payroll-deducted personal loans. We add the possibility for households to contract long-term debt and compare two different types of credit constraints with one another, one based on housing and the other based on future income. We estimate the model for Brazil using a Bayesian technique. The model is able to solve a puzzle of the Brazilian economy: responses to monetary shocks at first appear to be strong but dissipate quickly. This occurs because income – and the amount available for loans – responds more rapidly to monetary shocks than housing prices. To smooth consumption, agents (borrowers) compensate for lower income and for borrowing by working more hours to repay loans and erase debt in a shorter time. Therefore, in addition to the income and substitution effects, workers consider the effects on their credit constraints when deciding how much labor to supply, which becomes an additional channel through which financial frictions affect the economy.
Understanding the recovery of Ruthenium from acidic feeds by oxidative solvent extraction studies
Authors: Verma Parveen Kumar , Gujar Rajesh Bhikaji , Mohapatra Prasanta Kumar
Published: February 2019

Ruthenium (106Ru), a notorious fission product in nuclear reprocessing cycle, which gets partitioned at each step needs to be recovered. The recovery of Ru from acidic high level waste (HLW) is of great importance to the nuclear fuel cycle. Quantitative recovery of Ru was achieved from acidic feeds using oxidative trapping mechanism strategy where NaIO4 was used as an oxidant to convert different species of Ru in acidic phase to RuO4 while n-dodecane was used as trapping agent for RuO4. Stripping was attempted using NaOH and NaClO mixture. Attempt was made to optimize various parameters for 103Ru extraction and stripping. 103Ru tracer spiked simulated high level waste was used to understand the 103Ru behaviour in actual waste. The composition of stripping solution (alkaline hypochlorite) was also optimized to have >95% Ru into the aqueous phase in ca. 180 min.
New high temperature resistant heavy concretes for fast neutron and gamma radiation shielding
Authors: Aygün Bünyamin , Şakar Erdem , Korkut Turgay , Sayyed Mohammed Ibrahim , Karabulut Abdülhalik
Published: February 2019

In the present work, we developed three new high temperature resistant heavy concretes as novel radiation shielding materials. For this purpose, chrome ore (FeCr2O4), hematite (Fe2O3), titanium oxide (TiO2), aluminum oxide (Al2O3), limonite [FeO (OH) nH2O], siderite (FeCO3), barite (BaSO4), nickel oxide (NiO) materials and alumina cement were used. Mass combination ratios of components and total macroscopic cross sections (scattering, absorption, capture, fission) of the samples were calculated by using GEANT4 code. The resistances of the prepared samples were evaluated in terms of compression strength after exposure at the 1000 °C temperature. Neutron equivalent dose rate measurements were carried out by using 4.5 MeV 241Am-Be neutron source and BF3 detector. All results were compared with normal weight concrete and paraffin. The results of neutron dose indicate that neutron absorption ability of the new heavy concretes is higher than normal weight concrete and paraffin. In addition to neutron measurements, different γ-ray shielding parameters such as mass attenuation coefficient (MAC), effective atom numbers (Zeff), half value layer (HVL) and mean free path (MFP) have been calculated using WinXCOM software in order to investigate the effectiveness of using the prepared concretes as a radiation shielding materials. Gamma-ray results were compared with concretes and Pb-based glass.
Contra-Hedonic Attitudes Toward Pleasant Emotions in China: Links to Hedonism, Emotion Expression, and Depression
Authors: Deng Xinmei , Ding Xuechen
Published: February 2019

Introduction: Contra-hedonic attitudes toward pleasant emotions are culturally dominant in Chinese culture, but less is known about its links with hedonism, emotion expression and depression.

Method: We examined how attitudes toward pleasant emotions (measured by the Implicit Association Test) mediated the relation between hedonism and emotion expression (Study 1) and whether contra-hedonic attitudes toward pleasant emotions moderated the relation between emotion expression and depression (Study 2).

Results: Chinese implicitly evaluated pleasant emotions as negative and valued hedonism less important in daily lives. As less important in Chinese culture, hedonism may shape individual emotion expression through the influence of implicit attitudes toward pleasant emotions. In line with prior research, emotion expression was associated with higher level of depression. However, this relation was moderated by the extent to which individual evaluated pleasant emotions as negative.

Discussion: These findings highlight the importance of how people evaluate pleasant emotions to understand emotion expression and emotional states from a cultural perspective.
Cortical Tracking of Speech-in-Noise Develops from Childhood to Adulthood
Authors: Vander Ghinst Marc , Bourguignon Mathieu , Niesen Maxime , Wens Vincent , Hassid Sergio , Choufani Georges , Jousmäki Veikko , Hari Riitta , Goldman Serge , De Tiège Xavier
Published: February 2019

In multitalker backgrounds, the auditory cortex of adult humans tracks the attended speech stream rather than the global auditory scene. Still, it is unknown whether such preferential tracking also occurs in children whose speech-in-noise (SiN) abilities are typically lower compared with adults. We used magnetoencephalography (MEG) to investigate the frequency-specific cortical tracking of different elements of a cocktail party auditory scene in 20 children (age range, 6–9 years; 8 females) and 20 adults (age range, 21–40 years; 10 females). During MEG recordings, subjects attended to four different 5 min stories, mixed with different levels of multitalker background at four signal-to-noise ratios (SNRs; noiseless, +5, 0, and −5 dB). Coherence analysis quantified the coupling between the time courses of the MEG activity and attended speech stream, multitalker background, or global auditory scene, respectively. In adults, statistically significant coherence was observed between MEG signals originating from the auditory system and the attended stream at <1, 1–4, and 4–8 Hz in all SNR conditions. Children displayed similar coupling at <1 and 1–4 Hz, but increasing noise impaired the coupling more strongly than in adults. Also, children displayed drastically lower coherence at 4–8 Hz in all SNR conditions. These results suggest that children's difficulties to understand speech in noisy conditions are related to an immature selective cortical tracking of the attended speech streams. Our results also provide unprecedented evidence for an acquired cortical tracking of speech at syllable rate and argue for a progressive development of SiN abilities in humans.

SIGNIFICANCE STATEMENTBehaviorally, children are less proficient than adults at understanding speech-in-noise. Here, neuromagnetic signals were recorded while healthy adults and typically developing 6- to 9-year-old children attended to a speech stream embedded in a multitalker background noise with varying intensity. Results demonstrate that auditory cortices of both children and adults selectively track the attended speaker's voice rather than the global acoustic input at phrasal and word rates. However, increments of noise compromised the tracking significantly more in children than in adults. Unexpectedly, children displayed limited tracking of both the attended voice and the global acoustic input at the 4–8 Hz syllable rhythm. Thus, both speech-in-noise abilities and cortical tracking of speech syllable repetition rate seem to mature later in adolescence.
El boletín ASCUBI Villa Clara, reflejo del acontecer informativo en el centro de Cuba
Authors: Frías Guzmán Maylin , Paz Enrique Luis Ernesto , Alomá Cires Cristina , Tamayo Rueda Deymis , Hernández Alfonso Eduardo Alejandro
Published: February 2019

Los boletines de las asociaciones bibliotecarias en Cuba alcanzan gran auge a partir de la década de 1930. ASCUBI Villa Clara surge en 1990 como una publicación desarrollada en el ámbito de una provincia en la región central de Cuba. El boletín intentó recoger algunos detalles históricos de la asociación. Sobre ASCUBI Villa Clara solo se encuentran anotaciones descriptivas sobre la composición, estructura y personalidades vinculadas a su publicación. Se plantea como objetivos valorar la contribución del boletín ASCUBI Villa Clara para la profesión bibliotecaria en el territorio y analizar la estructura de la publicación desde lo técnico, lo formal y lo comunicativo. Se identificaron varios aspectos históricos de la publicación a partir del análisis de los documentos y la entrevista a las personas involucradas con la publicación. Además, se especificaron aspectos técnicos, formales y comunicativos que caracterizaron el boletín.
Zhuangzi’s concept of harmony and its cultural implications
Authors: Maliavin Vladimir V.
Published: February 2019

Tamkang UniversityThe ancient Daoist philosopher Zhuangzi (beginning of the 4th century BC), whose views comprise the core of the book ascribed to him, offers a profound concept of harmony, the basic condition of which is the differential relation within the continuity of universal change. Harmony for Zhuangzi is the predetermined or rather in-determined power of self-affection which constitutes the nature of life. As such it stands for the symbolic matrix of experience anticipating the world of things. This idea of harmony lies at the origin of creativity and style in culture. Zhuangzi’s philosophy is neither nihilistic nor apologetic in relation to actual cultures but provides, as it were, a comment on the conditions of the formation of culture.
Actuality and potentiality in Dignāga’s understanding of immediate perception (nirvikalpaka pratyakṣa) according to his Pramāṇasamuccaya and Ālambanaparīkṣā
Authors: Lysenko Viktoria
Published: February 2019

Institute of Philosophy, Russian Academy of SciencesOn the one hand, Dignāga supposes in his Pramāṇasamuccaya (part 1) that immediate perceptual experience at every given moment has as its object something that never goes beyond its own actually present content and thus may characterise only itself (svalakṣaṇa). In that respect, svalakṣaṇa appears as a kind of mere presence, sheer momentary actuality. It cannot undergo any external influence or exercise its own influence on other svalakṣaṇas. In other words, it cannot be extended to things other than itself, as is the case of mental constructions. First, I would like to ask whether there is a potentiality in the act of immediate perception according to the Pramāṇasamuccaya. On the other hand, in the Ālambanaparīkṣā, cognition is an entirely interior process manifests itself as a sense organ to an internal cognisable form. Second, I would like to dwell on the question concerning whether an immediate perception of svalakṣaṇas, free from mental constructions, is still possible in the Ālambanaparīkṣā.
Remembering the atomic bombing of Hiroshima and Nagasaki: Collective memory of post-war Japan
Authors: Okuda Hiroko
Published: February 2019

Nanzan UniversityThis study examines the way in which Tokyo has exploited the atomic bombing of Hiroshima and Nagasaki as a symbolic means of inducing post-war Japanese collective identity. To consider an effort on Tokyo’s part to integrate A-bomb memories into the country’s victim consciousness rather than to overcome the past, the study compares the A-bombed cities written with different Japanese forms, the peace parks, and the peace memorials. It also analyses the news coverage by two national daily papers on the A-bomb memorial days. By doing so, the study shows how the nation has been guided in its memory by the government.
Jean-Anri Fabre – great naturalist and entomologist
Authors: Кrut’ M. V.
Published: February 2019

During 30 years Jean-Anri Fabre had been studying insects and retained a greatest literary legacy. His dissertation was devoted to digger wasps (Sphecidae), with emphasis on their food specialization and habits. At the field entomological station Fabre studied development and mode of life of beetles (Attelabidae, Scarabaeidae, Silphidae), flies, other insects and scorpions. He detected the phenomenon of hypermetamorphosis in development of beetle Sitaris muralis (Meloidae), revealed the extra-intestinal digestion of fly larvae, drawn a conclusion about existence of insects’ instinct. The results of research works were published in 10 volumes of book entitled «Entomological Memoirs», among these four books were devoted to wasps. Other books of Fabre are «The Life of Insects», «Instinct and Customs of Insects», «Dung Beetles», «Wasps», «Bees». Fabre’s ideas are of importance for agriculture and forestry. His observations revealed new possibilities of insect pests’ control. It is possible to draw data on biological method of control from his exact descriptions. Jean-Anri Fabre was chosen an honorary member of Russian entomological society.
Bioinspired immobilization of carbon nanotubes on scaffolds for nerve regeneration
Authors: Nazeri Niloofar , Tajerian Roksana , Arabpour Zohreh , Hadjighassem Mahmoud Reza , Gheibi Nematollah , Manouchehrabadi Mahboubeh , Ghanbari Hossein
Published: February 2019

Carbon nanotubes (CNTs) have different applications in regenerative neurology such as neural signal transfer, nerve tissue engineering and neuroprosthetic devices. Their electrical conductivity and biocompatibility make them appropriate candidates for cell stimulation. This study was conducted to determine whether polydopamine (PD) can immobilize CNTs on the surface of nanofibrous scaffolds. To investigate this, electrospun scaffolds of poly(lactide-co-glycolide) (PLGA) were coated with CNTs both directly and by means of PD. Scanning electron microscopy (SEM), water contact angle measurement and Raman spectroscopy were used to verify the presence of dopamine on the surface of the scaffolds. The presence of PD on the substrate surface decreased the contact angle from 135·92 ± 2 to 82·65 ± 2°. Raman spectroscopy confirmed results by appearance of new peaks at 1350 and 1582 cm−1, which correspond to the aromatic component of PD. Measuring the electrical resistance proved that dopamine could effectively immobilize CNTs on the surface of nanofibers, decreasing the electrical resistance to 5·5 kΩ/square. Likewise, SEM images revealed a change in surface morphology induced by PD coating. Finally, cell viability studies demonstrated that CNT–PD–PLGA had no toxic effect on PC12 cells. The preliminary results were promising, supporting potential application of these materials as conductive scaffolds in nerve cell stimulation.
Load behaviour of model strip footings on reinforced transparent soils
Authors: Chen J.-F. , Guo X.-P. , Xue J.-F. , Guo P.-H.
Published: February 2019

A number of loading tests were performed in the laboratory on strip footings resting on unreinforced and geotextile reinforced transparent soils. Fused silica sand and white oil were used to manufacture the transparent soils. Reinforcement layers with different lengths were placed at a vertical spacing of 0.25B and 0.5B, with reinforcing depths varying from 0.5B to 2B (B is the width of the strip footing), and reinforcing widths ranging from 1B to 7B. The deformation of the reinforcement layers and soil was monitored using digital cameras with the aid of a laser transmitter to highlight the deformation of the reinforcement layers. Two peaks were observed in the load-settlement curves of some footings on soils with reinforcements at 0.5B spacing. The deformation of the reinforcement layers showed that each peak point is related to the failure of one layer of reinforcement, indicating the progressive development of reinforcement failure into deeper layers. Most of the footings on soils with reinforcement layers at 0.25B spacing showed brittle failure behavior, which was due to the near-simultaneous rupture of the reinforcement layers. It was also found that longer reinforcement does not always provide greater bearing capacity at certain reinforcement spacings.
Evaluation of soil-geogrid interaction using transparent soil with laser illumination
Authors: Peng X. , Zornberg J. G.
Published: February 2019

An experimental methodology was developed involving techniques that allow non-intrusive measurement of confined geogrid deformations and soil particle displacements under pullout loading condition, which together are expected to generate a comprehensive volume of data including the entire displacement field in both geogrid and surrounding soil. The techniques involve the use of transparent soil with laser-aided imaging, which allows visualization and facilitates subsequent evaluation of the load-transfer mechanisms that develop between soil particles and the different rib elements in geogrids. A laser beam was employed to track the transparent soil particles in a plane perpendicular to the soil-geogrid interface. The collimated laser beam produced well-defined individual particles in the selected plane of the soil model. Digital cameras were used to track the displacement fields of both the confined geogrid specimen and soil particles within the laser-illuminated plane. Digital image correlation as well as other image-processing techniques were used to define the displacement fields based on images captured during the tests. The field displacements resulting after processing the data gathered from the newly developed experimental system led to well defined manifestations of the load transfer mechanisms, including the deflection patterns in geogrid ribs and shear bands within the soil mass.
A new image-based technique for measuring pore size distribution of nonwoven geotextiles
Authors: e Silva R. A. , Negri R. G. , de Mattos Vidal D.
Published: February 2019

The use of digital images to evaluate geotextile characteristics has appeared in the scientific literature, particularly for estimating the pore size distribution (PSD) of nonwoven geotextiles used for filtration purposes. While numerous image analysis techniques for PSD curve estimation have been proposed, automation of the analysis methods has received almost no attention. The goal of the present study is to quantify PSD curves from images of representative geotextile specimens using a fully automatic algorithm and considering the concept of largest inscribing opening size. These features are incorporated in a software program (GeotexInspector) developed by the second author. GeotexInspector is based on the concept of classification using the Support Vector Machine technique and digital image processing. These techniques are combined to develop a tool with a robust learning algorithm to identify geotextile fibers and pores. PSD curves from continuous filament and staple fiber nonwoven geotextiles are estimated using GeotexInspector and then compared with theoretical models that have appeared in the literature. The results indicate that the curves obtained from image analysis are in good agreement with model outcomes for models focused on the structure of geotextiles that are similar to the geotextiles used in this study.
Beyond shelter: the urban house as an entrepreneurial resource
Authors: Khandkar Shantanu Bindumadhav , Khandkar Janhavi Shantanu
Published: February 2019

For the urban poor, a house represents more than shelter. It is also a resource which can be used for generating income and thus plays an important role in the economy. Since independence, policies adopted by successive governments in India to address the problem of housing for the urban poor have undergone considerable changes. The government's role has shifted from being a direct provider to an enabler. The design processes and delivery mechanisms for housing are concerned with addressing only the need or demand for shelter. On the contrary, in scenarios where the people have had a more active role in the production of housing, it has been observed that the house is not just seen as shelter but also as a place adaptable for income generation, thereby enabling it to play an important role in the informal well as, in some cases, formal economy. By studying various housing typologies found in the city of Mumbai and the legislative, financial and operative models that produced them, the paper argues that the lack of these characteristics in the final product is one of the reasons for the government housing schemes finding limited success.
hsp70 C PCR-RFLP v1
Authors: Lima Ana
Published: February 2019

The hsp70 PCR-RFLP assay described by Graça et al. (2012) enables to identifify different species of the genus Leishmania. Graça et.al. (2012) described four different primer pairs and associated with some restriction enzymes for the identification of Leishmania species.The hsp70 PCR-RFLP assay using the hsp70 C primers described by Graça et al. (2012) amplify a 234 base pairs (bp) fragment. It was standardized in our laboratory with some modifications and has contributed significantly to the identification of species of Leishmania especially of the subgenus Leishmania (Viannia) sp.
Readers as the Subjects of Ukrainian Book Publishers’ Communication in the Modern Media Space
Authors: Yezhyzhanska Tetiana
Published: February 2019

The influence of readers on the communication of the publishing organization in the modern media space was analysed in this study. The main objective was to find out the role of readers in the communication of book publishers in Ukraine.

To achieve the objective of the study, the author used the method of analysis of scientific sources and the method of scientific generalization. The author also applied the method of observation through polling the visitors of the Book Arsenal in Kyiv and the Book Forum in Lviv during 2016-2018.

It was explored that among the visitors of the largest Ukrainian book publishing forums, one-third of the active media consumers were interested in the events of the book publishing market, they created and distributed media content by themselves.

It was proved that active consumers became prosumers and effectively influenced the communication policy of the publishing houses.

It was recommended to the publishers’ PR-managers to properly consider modern changes in the media space which influence the readership activity, to adopt a culture of interaction with the readers, to use them as an effective source of dissemination of information about book novelties, and to try turn them into promoters of the publishing houses’ brands.
Harmful and hazardous alcohol consumption among individuals with high risk of HIV infection
Authors: Plavinskii Svyatoslav L. , Ladnaya Natalia N. , Zaytseva Elena E. , Barinova Anna N.
Published: February 2019

Hazardous and harmful alcohol consumption was studied in high-risk groups for HIV infection acquisition using respondent-driven sampling and time-location sampling in 7 regions of Russian Federation. The prevalence of hazardous and harmful alcohol consumption was high with regional variations. Prevalence of hazardous and harmful alcohol consumption was highest among injection drug users in Tomsk (89.96% (95 % CI 87.14–92.78%)) and lowest among men who have sex with men in St. Petersburg (43.31% (95% CI 37.03–49.59%)). In general about two thirds of the groups reported hazardous and harmful alcohol consumption. As a marker of unsafe sexual behavior the answer to the question about non-use of condom was selected. There was heterogeneity among regions especially in female sex-workers reports. Use of meta-analytic summarization showed that people that reported hazardous and harmful alcohol consumption had tendency to more risky sexual behavior, though results were not statistically significant due to high prevalence of hazardous and harmful alcohol consumption. These results show need to incorporate screening for hazardous and harmful alcohol consumption into prevention programs for high-risk individuals.
Modern methods of treatment and rehabilitation of patients with acne vulgaris
Authors: Barinova Anna N.
Published: February 2019

The article reviews contemporary data on diagnosis and management of acne. Special attention is paid to differential diagnosis of acne and treatment of acne-like disorders. The contemporary approaches to the acne therapy are described in detail with special attention paid to the systemic treatment with hormonal contraceptives, isotretionin, antibiotics and systemic corticosteroids. The algorithms of acne management are given and also recommendations on prevention of relapses are provided.
Parameters Assessment of the FMEA Method by Means of Fuzzy Logic
Authors: Bonato Jasminka , Badurina Martina , Dobrinić Julijan
Published: February 2019

The paper aims at presenting the FMEA method based on the fuzzy technique, representing a new approach to the failure analysis and its effects on the observed system. The FMEA (Failure Mode and Effect Analysis) method has assigned the risks a coefficient i.e. a numerical indicator that very clearly defines the degree of risk. The risk is calculated as a mathematical function of RPN which depends on the effects S, probability O that some case will lead to a failure and to a probability that a failure D can not be detected before its effects are realized. RPN = S O D. The FMEA method, based on the fuzzy logic, makes a more reliable evaluation of the observed system failures possible.
Pregnancy and live birth rates in women with endometriosis related infertility in Latvia
Authors: Avdotina Jekaterina , Mezecka-Oleinika Aleksandra , Silina Vija , Vitina Zane
Published: February 2019

Background: Women with endometriosis experience painful symptoms and/or infertility, others have no symptoms at all. According to European Society of Human Reproduction and Embryology guidelines, surgery and assisted reproductive technologies (ART) are an appropriate treatment in cases of endometriosis-associated infertility. There are controversial data on the results of surgery and ART in patients with endometriosis.Methods: Retrospective analysis including 99 infertile patients aged between 25 and 48 years old. All of them had laparoscopic surgery as the primary option. 51 of them undergoing in vitro fertilization or intracytoplasmic sperm injection or frozen embryo transfer from 2003 through 2018 at SIA ‘Clinic EGV’.Results: The mean age of women was 34.2±4.5. In 56 (33.5%) cases was only surgery with 28 (50.9%) biochemical pregnancies and 26 (48.1%) live birth. In 111 (66.5%) cases there were surgery with ART with 48 (47.6%) biochemical pregnancies and 23 (22.7%) live birth. In 1 group patients mean age 30.7±4.6 and 2 group with mean age 35.1±4.2 (p=0.000). It was found that there is significant difference between endometriosis phenotype, infertility type, duration of infertility, repeated laparoscopic surgery, ART cycles, retrieved oocyte count and biochemical pregnancy rate.Conclusions: Patients with endometriosis related infertility should undergo surgical treatment as the primary option. Those patients who do not become pregnant after surgery must be treated with assisted reproductive technology. The optimal time to perform ART is first year after endometriosis surgery.
Esomeprazole and pantoprazole enhance the antiproliferative effects of cisplatin on the human neuroblastoma SH-SY5Y cell line
Authors: Karademir Mustafa , Ergül Merve
Published: February 2019

Background: Proton pump inhibitors (PPIs) largely used a drug to treat gastroesophageal disease such as gastric ulcers. Moreover, in recent years, several studies suggest that PPIs have an important anti-cancer effect in monotherapy and or combination with chemotherapy. The aim of this study was to investigate whether esomeprazole and pantoprazole exhibit anti-cancer effect alone or could enhance chemosensitivity on the human neuroblastoma cell line SH-SY5Y to cisplatin.Methods: The human neuroblastoma SH-SY5Y cells were cultured and treated with different concentrations of esomeprazole, pantoprazole, and cisplatin alone. Also, these cells exposed to cisplatin+ esomeprazole and cisplatin + pantoprazole combinations, respectively and incubated 24 h. The antiproliferative activities of the (PPIs) alone or in a combination of cisplatin was evaluated using the XTT colorimetric assay.Results: According to experimental data, neither PPIs showed no cytotoxicity on the human neuroblastoma cell line SH-SY5Y at all concentrations. However, when combined with cisplatin separately, they were found to have significant antiproliferative effects on the human neuroblastoma SH-SY5Y cell lines when compared to cell lines treated with cisplatin alone (p<0.05).Conclusions: Taken together, the inhibition of V-ATPase via esomeprazole and pantoprazole might enhance the chemosensitivity of cisplatin on the human neuroblastoma cell line SH-SY5Y. However, further studies are needed to be able to utilize PPIs in human neuroblastoma cells.
Study of prevalence of vitamin D deficiency in nephrotic syndrome
Authors: Illalu Shivanand , Venkatareddy Velagala Swetha , Fattepur Sudhindrashayana R.
Published: February 2019

Background: Patients with nephrotic syndrome (NS) lose 25-hydroxyvitamin D in the urine and can have low blood levels of this metabolite. Corticosteroid therapy on long term basis can cause osteoporosis and affects the bone mineral content (BMC) and bone mineral density (BMD) in children. Hence this study was undertaken to study the prevalence of Vitamin D deficiency in children with Nephrotic syndrome.Methods: It is a time bound prospective hospital based observational study done at Department of Paediatrics, KIMS Hospital, Hubli. A detailed history and clinical examination including anthropometry was taken for cases of Nephrotic syndrome admitted to the hospital. 5ml venous blood was collected and sent for estimation of calcium (Ca), phosphorus (P), Alkaline phosphatase (ALP) and 25(OH) Vitamin D levels.Results: Mean age of onset of nephrotic syndrome was 4.6 years and median age at study entry was 7 years. Male to female ratio was 1.4:1. Vitamin D deficiency was present in 16(47.05%) children and insufficiency was present in 11(32.35%) children with nephrotic syndrome. Wasting was present in 11.76% and stunting was present in 50% of the children with nephrotic syndrome. There was no statistically significant difference of vitamin D levels with respect to sex and age group. Frequent relapsers had low levels of vitamin D levels as compared to 1st episode and infrequent relapsers. There was moderately significant positive correlation between serum calcium and vitamin D levels and negative correlation between phosphate levels and vitamin D levels.Conclusions: Vitamin D deficiency is common in children with nephrotic syndrome even after the remission of proteinuria.
Efficient learning with intelligent tutoring across cultures
Authors: Aravind Vasudeva Rao , Refugio Craig
Published: February 2019

Science and engineering departments face high student attrition due to perceived difficulty of courses in these disciplines. To subdue student attrition, students need to be guided by individual tutors to help them learn, practice and test their understanding of concepts. However, due to the exorbitant cost and time involved, this is not practical. In this article, we argue that computer-based tutors authored by teachers can serve as a useful tool to assist student learning in challenging scientific concepts. About 8,000 fine-grained interactions with our tutor by 72 students in two countries—USA and Philippines—were analysed in the framework of learning curve theory to estimate prior knowledge, learning rate and residual error rate to gauge tutor efficiency. Computer-based tutors accelerate learning and such tutors are viable, effective, and facile options to improve student learning.Keywords: Intelligent tutoring, physics education, engineering education, educational technology.
An examination of digital footprint awareness and digital experiences of higher education students
Authors: Sürmelioğlu Yeşim , Seferoğlu Süleyman Sadi
Published: February 2019

Rapid changes are occurring in life owing to information and communication technologies. During this change period, digitalidentities have begun to emerge. These identities are associated with actions that users perform in online environments. Adigital footprint is formed with these actions. The purpose of this study is to determine the digital footprint awareness anddigital footprint experiences of higher education students. In order to collect data for the study, researchers developed adata collection tool titled â€˜A survey for digital media useâ€™. The study group consisted of 508 higher education students from41 Turkish universities. Data were collected through an online-form where participation was on a volunteer basis. Thefindings of the research show that students have a high level of digital footprint awareness ( x = 4.251) and a low level ofdigital footprint experience ( x = 1.907).Keywords: Digital footprint, digital footprint awareness, digital footprint experiences, higher education students.
Narración de cuentos como propuesta didáctica para abordar temas culturales en un salón de clase de alumnos de quinto grado
Authors: Esteban Nuñez María Teresa , Gómez Ríos Ana Victoria
Published: February 2019

Esta investigación se desarrolló con diez alumnos de quinto grado en el Colegio Inem Carlos Arturo Torres, sede Las Américas, en Tunja, Colombia. Los objetivos de este estudio fueron guiar a los estudiantes para que adquirieran más conocimientos sobre otras culturas así como también de la propia, tomaran conciencia de las diferencias culturales y desarrollaran percepciones más positivas y aceptables de diferentes culturas. En este sentido, algunas historias fueron presentadas utilizando grandes libros que fueron diseñados e implementados en el aula de inglés. Los instrumentos empleados en esta investigación-acción para recolectar datos fueron artefactos del estudiante, discusiones de grupo y dos encuestas. Los resultados revelaron que las historias impactaron directamente en el conocimiento de los estudiantes y en su comprensión de otras culturas, así como de la colombiana. Esta estrategia también les ayudó a construir su vocabulario y a transformar la manera en que estaban acostumbrados a desarrollar las clases de inglés. Con esta actividad ellos encontraron sus clases más interesantes y dinámicas.