bluuebunny/crossref_metadata_2025 huggingface dataset:
Performances Analysis of SPWM Inverter-Fed Three Phase Induction Motor during Fault Conditions
Authors: Youns Yasir Mohammed , Hassan Omer Mohammad
Published: March 2022

Induction motors are the most widely used electrical machines and the most popularly in the industrial applications, aerospace, and electrical vehicles or hybrid electrical vehicles. This celebrity of these machines because of some of their benefits such as: relatively low manufacturing cost, robust construction, moderate power factor, ability to operate in hostile environments, good reliability, and ease of control especially in the recent years. In fact, induction motors are the main component of many of these applications and they are used in the most of these applications with their power electronic drivers in order to control their speeds, torques, or control their starting conditions. However, these motors and their drivers may encounter several faults due to operating conditions. In fact, these faults are either due to the motor itself or due to its power electronic driver circuit. Therefore, this paper presents the performance analysis and simulation of a Sinusoidal pulse width Modulation (SPWM) inverter-fed three-phase induction motor under some fault conditions. Two different types of faults are studied and analyzed in detail. These faults were: driver single switch short circuit fault, and driver single switch open circuit fault. The motor currents and voltages at pre-fault and post-fault conditions are presented and investigated. In the two fault cases, the motor phase currents are changed and increased, but in different ratios, under same load conditions. Also, decreasing and oscillating in both motor speed and its developed torque are occurred due to these faults. The simulation and analysis results show that the single switch short circuit fault has the sever effect on the motor performance, therefore especial care should be taken under this fault conditions.
HUBUNGAN AKTIVITAS FISIK DENGAN INDEKS PRESTASI KUMULATIF PADA MAHASISWA PREKLINIK FKIK UNIKA ATMA JAYA
Authors: Lionardi Stevan Kristian
Published: March 2022

ABSTRAK

Latar Belakang: Bagi mahasiswa kedokteran, proses pembelajaran merupakan unsur esensial guna memperoleh pengetahuan dan keterampilan yang diperlukan untuk menjadi seorang dokter. Proses pembelajaran akan bahan dan materi yang banyak seringkali menghabiskan banyak waktu, mengakibatkan kurangnya intensitas dan perhatian akan pentingnya kegiatan aktivitas fisik yang rutin dan teratur yang dapat meningkatkan fungsi kognitif dan eksekutif otak.

Metodologi: Desain penelitian ini adalah potong lintang dengan metode random sampling dengan responden sebanyak 103 mahasiswa angkatan 2016, 2017, dan 2018 Fakultas Kedokteran dan Ilmu Kesehatan Prodi Kedokteran Universitas Katolik Indonesia Atma Jaya dengan menggunakan kuesioner IPAQ (International Physical Activity Questionnaire) untuk mengukur intensitas aktivitas fisik dan untuk mengetahui indeks prestasi mahasiwa disertai pertanyaan nilai indeks prestasi kumulatif mahasiswa melalui kuesioner. Uji analisis yang dilakukan adalah uji non parametrik Chi-square.

Hasil: Hasil dari analisis data menggunakan uji Chi-square antara intensitas aktivitas fisik dengan indeks prestasi kumulatif mahasiwa menunjukkan nilai Pearson Chi-Square hitung adalah 0,048, meski telah memenuhi syarat p < 0,05 namun memiliki perbedaan yang sedikit dengan nilai yang tidak signifikan, sehingga hubungan antara kedua variable dapat dipandang dari kedua sisi.

Kesimpulan : Peningkatan aktivitas fisik dapat mempengaruhi peningkatan nilai indeks prestasi kumulatif yang dimiliki, namun masih terdapat banyak faktor-faktor lain yang dapat mempengaruhi nilai indeks prestasi kumulatif seorang mahasiswa kedokteran.
Association Between Cognitive Function and Balance Among The Elderly In Jakarta
Authors: Karyn Ireina , Handayani Maria Dara Novi , Darmawan Octavianus
Published: March 2022

Introduction: The world is entering an aging population. With aging comes many challenges due to changes of the brain structure that affect both cognitive function and balance. The amount of cognitive function and balance impairment cases in the elderly are rising. If left unattended, it can cause numerous adverse effects in the elderly, eventually leading to the loss of the ability to perform activities of daily living. Studies have observed the relationship between cognitive impairment and balance in Indonesia, but only a few were conducted in Jakarta, specifically among elders in the nursing home. This study is aimed to observe the association between cognitive function and balance in the elderly.Methods: This is a secondary analysis using a previous study conducted in PSTW Budi Mulia Jakarta in 2016. Demographic data, cognitive function, and balance were assessed using the demographic questionnaire, Mini-Mental State Examination (MMSE), and Berg Balance Scale (BBS). Statistical analysis is conducted using IBM SPSS Ver 22.Results: Most respondents were female, aged 60-69 years old, had low education level, good MMSE score (53,3%), and a normal BBS (90,7%) score. We found a significant relationship between cognitive functions and balance (p=0,045).Conclusion: Cognitive function is related to balance impairment in the elderly.

Key Words: balance, cognitive function, elderly
Síndrome Multissistêmica Inflamatória Pediátrica no contexto da pandemia da Covid-19: uma revisão de literatura
Authors: De Oliveira Maria Eduarda Luizeto , Oliveira Carla Resende Vaz , De Oliveira Felipe Alves , Gilberto Manuela Pinho Marinho , Dos Santos Marcella Simão , Campos Mariane Barros Ribeiro , Almeida Thalissa de Almeida Werneck , Reis Bruno Cezario Costa
Published: March 2022

Objetivo: Elucidar o principal sintoma dos critérios diagnósticos apresentados e o contexto imunológico do SARS-CoV-2 associado a Síndrome Multissistêmica Inflamatória Pediátrica (PIMS) presente na população pediátrica durante a pandemia da Covid-19. Métodos: Trata-se de um estudo retrospectivo de análise qualitativa e transversal realizado a partir de uma revisão integrativa de literatura. Em abril de 2021, foram utilizadas as seguintes bases de dados: National Library of Medicine (PubMed) e ScienceDirect. Os descritores aplicados em ambas as fontes de dados foram “Kawasaki disease like”, “COVID 19” e “association”. O critério de inclusão foi artigos disponíveis gratuitamente e, como critérios de exclusão, os artigos duplicados, aqueles com fuga do tema principal e tipos de artigo (revisão de literatura, artigos de hipótese, editorial e manual). Resultados: Dentre os 24 artigos selecionados, observou-se que 23 demostraram envolvimento cardíaco. Em relação a tal acometimento, 14 artigos apresentaram a presença de hipotensão. Dos 22 artigos que demostraram positividade para o vírus, 11 confirmaram imunoglobulina G reagente e 4 demostraram resultado negativo para SARS-CoV-2. Considerações finais: A PIMSportanto, é uma resposta da agressão do SARS-CoV-2 que atinge, principalmente, o sistema cardíaco causando hipotensão. Por isso, é importante o conhecimento da doença pelos profissionais de saúde.
Intracranial hemorrhage associated with direct oral anticoagulant after clipping for an unruptured cerebral aneurysm: A report of two cases
Authors: Koji Takahiro , Kubo Yoshitaka , Matsumoto Yoshiyasu , Akamatsu Yosuke , Chida Kohei , Kashimura Hiroshi , Ogasawara Kuniaki
Published: March 2022

Background:

Two cases of patients who developed intracranial hemorrhage associated with direct oral anticoagulant (DOAC) use after clipping of an unruptured cerebral aneurysm (uAN) are presented. These cases will help neurosurgeons assess the risks of patients with atrial fibrillation or deep venous thrombosis receiving DOACs who require craniotomy.

Case Description:

Case 1 was a 65-year-old man on apixaban 10 mg/day who underwent clipping for a left middle cerebral artery uAN. Apixaban was discontinued 72 h before surgery. During surgery, a thin and pial artery bled slightly at 1 point of the frontal lobe, and hemostasis was easily achieved. Computed tomography (CT) 19 h after surgery showed no evidence of intracranial hemorrhage. He was treated with a heparin-apixaban bridge from 29 h to 41 h after surgery. CT showed a left subarachnoid hematoma 24 h later. Case 2 was a 73-year-old woman on dabigatran 110 mg/day who underwent clipping for a right MCA uAN. Dabigatran was discontinued 48 h before surgery. During surgery, a thin and pial artery bled slightly at 2 points of the temporal lobe, and hemostasis was easily achieved. CT 19 h after surgery showed no evidence of intracranial hemorrhage. Dabigatran (110 mg/day) was restarted 29 h after surgery. CT then showed a right subarachnoid hematoma 94 h later, and dabigatran was discontinued, and it was then restarted 38 h later. However, 31 h later, CT showed an additional slight subarachnoid hemorrhage. Finally, she developed a right chronic subdural hematoma.

Conclusion:

In patients undergoing neurosurgical procedures, discontinuation of DOACs should be individualized based on neurosurgical bleeding risk and patient renal function. Restarting of DOACs could be considered after at least 48 h when hemostasis has been achieved. Bridging of DOACs cannot be recommended.
Visualization of ictal networks using gamma oscillation regularity correlation analysis in focal motor epilepsy: Illustrative cases
Authors: Nakamura Tomonobu , Sato Yosuke , Kobayashi Yusuke , Kawauchi Yuta , Shimizu Katsuyoshi , Mizutani Tohru
Published: March 2022

Background:

Focal motor epilepsy is difficult to localize within the epileptogenic zone because ictal activity quickly spreads to the motor cortex through ictal networks. We previously reported the usefulness of gamma oscillation (30–70 Hz) regularity (GOR) correlation analysis using interictal electrocorticographic (ECoG) data to depict epileptogenic networks. We conducted GOR correlation analysis using ictal ECoG data to visualize the ictal networks originating from the epileptogenic zone in two cases — a 26-year-old woman with negative motor seizures and a 53-year-old man with supplementary motor area (SMA) seizures.

Case Description:

In both cases, we captured several habitual seizures during monitoring after subdural electrode implantation and performed GOR correlation analysis using ictal ECoG data. A significantly high GOR suggestive of epileptogenicity was identified in the SMA ipsilateral to the lesions, which were connected to the motor cortex through supposed ictal networks. We resected the high GOR locations in the SMA and the patients’ previously identified tumors were removed. The patients were seizure-free without any neurological deficits after surgery.

Conclusion:

The GOR correlation analysis using ictal ECoG data could be a powerful tool for visualizing ictal networks in focal motor epilepsy.
TO THE QUESTION ABOUT THE POST-BUCKLING BEHAVIOR OF THIN COMPOSITE PLATES WITH NONSYMMETRIC STRUCTURE UNDER COMPRESSION AND UNEVEN LOCAL HEATING
Authors: Митрофанов О.В.
Published: March 2022

Получено аналитическое решение геометрически нелинейной задачи о закритическом поведении прямоугольной композитной панели при сжатии с учетом неравномерного локального нагрева. Применяемый вид прогиба описывает поведение коротких прямоугольных панелей, а исходные соотношения учитывают несимметричность структуры.

An analytical solution to the geometrically nonlinear problem of the post-buckling behavior of a rectangular composite panel under compression, taking into account the uneven local heating, is obtained. The applied type of defl ection describes the behavior of short rectangular panels, and the initial relations take into account the asymmetry of the structure.
ACTIVER SES RESSOURCES POUR BÂTIR SON AVENIR PROFESSIONNEL : Apport des neurosciences de l’éducation pour soutenir un projet de formation au-delà des troubles d’apprentissage
Authors: Buchwalder-Rais Véronique
Published: March 2022

La motivation est un facteur clé largement reconnu pour assurer l’engagement et la persévérance dans l’action. C’est également le cas dans le domaine des apprentissages scolaires.  De nombreux modèles théoriques de la motivation, souvent complémentaires, sont disponibles dans la littérature. Cependant, les articles qui envisagent le processus motivationnel sous l’angle de la neuroéducation sont encore peu nombreux. C’est l’objectif de cet article, dans lequel la motivation à apprendre est présentée comme le résultat d’un calcul de probabilité de type couts – bénéfices. Le focus est placé sur les élèves du secondaire, avec une attention particulière aux spécificités de leur développement cérébral d’adolescents. Des pistes d’intervention sont avancées, en vue de créer des conditions propices à la motivation d’apprendre, soit en réduisant la perception des coûts de l’engagement dans l’apprentissage, soit en augmentant la perception de ses bénéfices. Mots clés : Motivation, cerveau, éducation, neuroéducation, adolescence, école, scolaire   Abstract Motivation is a widely recognized key factor in ensuring commitment and perseverance in action. This is also the case in the field of school learning. Many theoretical models of motivation, often complementary, are available in the literature. Yet, articles that consider the motivational process from the neuroeducation perspective are still few. That is the purpose of this paper, in which motivation to learn is considered as the result of a cost-benefit probability calculation. The focus is on secundary level students, with particular attention to the specificities of their brain development as teenagers. Suggestions for interventions are proposed, in order to promote favourable conditions to support motivation to learn, either by reducing the perceived costs of engaging in learning, or by increasing the perception of its benefits. Keywords : Motivation, brain, education, adolescence, adolescents, school, neuroeducation
Learning and Memory : Neurosciences perspectives
Authors: Fahim Fahmy Cherine , Lina Awilé
Published: March 2022

Dans cette vidéo expliquative, Madame Lina Awilé, Master en psychologie, nous fait voyager avec élégance au fin fond du cerveau afin d'explorer les méandres de l'apprentissage et la mémoire.
Cette vidéo fait partie d'une série de trois vidéos expliquatives. 
In this explanatory video, Mrs. Lina Awilé, Master in Psychology, takes us elegantly to the depths of the brain to explore the intricacies of learning and memory.

This video is part of a series of three explanatory videos.
Medication Dosing Error Leading to Potentially Lethal Methotrexate Toxicity
Authors:   Clinical Pharmacist, Nepal Mediciti Hospital, Sainbu, Bhaisepati, Lalitpur, Nepal, S Poudel , B Khadka ,   Clinical Pharmacist, Nepal Mediciti Hospital, Sainbu, Bhaisepati, Lalitpur, Nepal, K Khanal ,   Clinical Pharmacist, Nepal Mediciti Hospital, Sainbu, Bhaisepati, Lalitpur, Nepal, A Ghimire ,   Clinical Pharmacist, Nepal Mediciti Hospital, Sainbu, Bhaisepati, Lalitpur, Nepal, A Regmi ,   Clinical Pharmacist, Nepal Mediciti Hospital, Sainbu, Bhaisepati, Lalitpur, Nepal
Published: March 2022

Pancytopenia is a rare consequence of rheumatoid arthritis treatment with low-dose methotrexate. Several literature reviews discovered earlier examples of severe pancytopenia caused by low- dose or dosage error of methotrexate. We discuss the case of a 67-year-old ACPA (Anti- citrullinated protein/peptide antibody) positive rheumatoid arthritis patient who had severe pancytopenia and oral mucositis as a result of methotrexate toxicity. To reduce medication dosing errors, we highlight its uncommon dose schedule.
Comparison between Rituximab and Cyclophosphamide in Treatment of ANCA-Associated Vasculitis on Remission Induction: A Meta-Analysis
Authors:   College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Henan, China, Wang Kena , hen Yongc ,   College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Henan, China, Xu Jiayun ,   Department of Endocrinology and Metabolism, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan, China
Published: March 2022

Objectives: Currently, immunosuppressants including cyclophosphamide and azathioprine are the main treatment options for anti-neutrophil associated vasculitis. However, since cyclophosphamide may cause serious adverse reactions, it is necessary to explore for a new drug, and rituximab is one option with less adverse reaction. There are a few studies on rituximab versus cyclophosphamide in the treatment of antineutrophil associated vasculitis. The meta-analysis is carried out to evaluate the efficacy of rituximab, compared with cyclophosphamide, as a remission induction therapy in AAV. Methods: Firstly we searched a Chinese database (CNKI, Wanfang) and English databases (Pubmed, Cochrane Library, Embase) according to inclusion criteria and exclusion criteria before October, 2021. Then Revman5.4 and Stata were used for data analysis which was then integrated by fixed effects or random effects. Results: After browsing the full texts, we finally included 7 eligible articles, involving 737 patients in total. With Revman5.4 software, we could draw the following conclusions: 6-month complete response rate (Chi²=0.46, df=1 P=0.50 I²=0%), 12-month complete response rate (Chi²=0.31 df=1 P=0.58 I²=0%), 18-month complete response rate (Chi²=0.18 df=1 P=0.67 I²=0%). Adverse event (Chi²=3.15 df=4 P=0.53 I²=0%), respectively for reached primary endpoint, failed primary endpoint in contrast. The result showed (Chi²=3.29 df=3 P=0.35 I²=9%, Chi²=1.72 df=2 P=0.42 I²=0%), 6-momth relapse, 12-momth relapse, 18-month relapse (Chi²=0.22 df=1 P=0.64 I²=0%, Chi²=0.04 df=2 P=0.98 I²=0%, Chi²=0.13 df=1 P=0.72 I²=0%), GPA 0f 6-month (Chi²=0.47 df=1 P=0.50 I²=0%), MPA of 6-month (Chi²=1.52 df=1 P=0.22 I²=34%). The above data are statistically significant. Conclusion: Based on the above data, we can conclude that compared with cyclophosphamide, rituximab can play a certain role in the treatment of ANCA disease, improve the complete response rate, reduce the rate of adverse reactions and recurrence, and is expected to replace cyclophosphamide as a first-line drug in clinical practice.
Electrochemical Depolymerization of Lignin in a Biomass-based Solvent
Authors: Alves da Cruz Márcia Gabriely , Gueret Robin , Chen Jianhong , Piątek Jędrzej , Sipponen Mika , Frauscher Marcella , Budnyk Serhiy , Rodrigues Bruno , Slabon Adam
Published: March 2022

The successive breakdown of the lignin macromolecule into smaller units is the key to generate high value-added products from this complex plant polyphenol. Obtaining well-defined aromatic compounds is, therefore, an important step towards the production of biobased chemicals for the fuel, coating and lubricant industries. Nevertheless, processes requiring lignin dissolution are always challenging. Dissolving this macromolecule in an environment-friendly way takes this challenge to a whole new level. Levulinic acid, an organic compound formed during the hydrothermal processing of lignocellulosic biomass, has been shown to efficiently dissolve lignin. Herein, we describe a system consisting of levulinic acid as a biobased solvent for the reductive electrochemical depolymerization of lignin. Copper was used as an electrocatalyst due to the economic feasibility and low activity towards the hydrogen evolution reaction. After depolymerization, high-resolution mass spectrometry and NMR structural characterization revealed lignin-derived monomers and dimers. A predominance of aryl ether and phenolic groups was observed. The effect of the depolymerized lignin as an anti-corrosion coating was assessed, revealing enhancements on the electrochemical stability of the metal. Via a simple depolymerization process of biomass waste in a biomass-based solvent, these results demonstrate a straightforward approach to produce high value-added compounds or tailored biobased materials.
Recombination Between ¹³C and ²H to Form Acetylide (¹³C₂²H‾) Probes Nanoscale Interactions in Lipid Bilayers Via Dynamic Secondary Ion Mass Spectrometry: Cholesterol and GM₁ Clustering
Authors: Grusky Dashiel , Moss Frank , Boxer Steven
Published: March 2022

Although it is thought that there is lateral heterogeneity of lipid and protein components within biological membranes, probing this heterogeneity has proven challenging. The difficulty in such experiments is due to both the small length scale over which such heterogeneity can occur, and the significant perturbation resulting from fluorescent or spin labeling on the delicate interactions within bilayers. Atomic recombination during dynamic nanoscale secondary ion imaging mass spectrometry (NanoSIMS) is a non-perturbative method for examining nanoscale bilayer interactions. Atomic recombination is a variation on conventional NanoSIMS imaging whereby an isotope on one molecule combines with a different isotope on another molecule during the ionization process, forming an isotopically enriched polyatomic ion in a distance-dependent manner. We show that the recombinant ion, ¹³C₂²H‾, is formed in high yield from ¹³C- and ²H-labeled lipids. The low natural abundance of triply labeled acetylide has makes it an ideal ion to probe GM₁ clusters in model membranes and the effects of cholesterol on lipid-lipid interactions. We find evidence supporting the cholesterol condensation effect as well as the presence of nanoscale GM₁ clusters in model membranes.
Fluorescent ligands targeting the intracellular allosteric binding site of the chemokine receptor CCR2
Authors: Toy Lara , Huber Max E. , Schmidt Maximilian F. , Weikert Dorothee , Schiedel Matthias
Published: March 2022

Fluorescently labeled ligands are versatile molecular tools to study G protein-coupled receptors (GPCRs) and can be used for a range of different applications, including bioluminescence resonance energy transfer (BRET) assays. Here, we report the structure-based development of fluorescent ligands targeting the intracellular allosteric binding site (IABS) of the CC chemo-kine receptor 2 (CCR2), a class A GPCR that has been pursued as a drug target in oncology and inflammation. Starting from previously reported intracellular CCR2 antagonists, several tetramethylrhodamine (TAMRA) labeled CCR2 ligands were designed, synthesized and tested for their suitability as fluorescent reporters to probe binding to the IABS of CCR2. By means of these studies, we developed 14 as a fluorescent CCR2 ligand enabling cell-free as well as cellular NanoBRET-based binding studies in a non-isotopic and high-throughput manner. Further, we show that 14 can be used as a tool for fragment-based screening approaches as well. Thus, our small molecule-based fluorescent CCR2 ligand 14 represents a promising tool for future studies of CCR2 pharmacology.
A Statistical Comparison between Zagreb indices for correlation with toxicity predictions of natural products
Authors: Siva Parvathi M.  , Sujatha D.  , Sukeerthi T.
Published: March 2022

Graph theory had wide applications in developing in silico tools and it is widely used to calculate topological indices to establish structural activity relations of chemicals/compounds. However, usage of Zagreb indices with respect to natural compounds activity/toxicity prediction needs more attention. Many available online tools are using atom bond connectivity index (ABC Index), first and second Zagreb indices. The usage of the Hyper Zagreb index is very rare and using natural compounds is neglected. In this context, three types of Zagreb indices (first Zagreb index, second Zagreb index and hyper Zagreb index) were calculated to the selected chemical compounds of natural products and the relation between these indices and cytotoxicity of natural compounds were established. We have selected IC50 Values of the selected natural compounds in Hela cell lines as an index for cytotoxicity from the literature. The correlation of Zagreb indices and activity was performed using the R program, and we reached the conclusion that all indices correlate with the cytotoxicity of the studied compounds. This study acts as evidence to prove that, hyper Zagreb index correlates more with the cytotoxicity/activity of the studied natural compounds. Further studies using other Machine Learning tools to verify these findings will establish the importance of the hyper Zagreb index as one method to predict the toxicity of natural compounds.
Religious and Ethno-Religious Extremism in the Conditions of Non-Transparency of World Politics
Authors:   Middle Russia Institute of Management – a Branch of the Russian Academy of National Economy and Public Administration, Isaev A. V. , Matvienko V. A. ,   Bunin Yelets State University
Published: March 2022

The article deals with the analysis of methodological and practical problems of studying religious and ethnoreligious extremism in modern society. The authors studied in detail the current conceptual estimations revealing interrelation between religion, terrorism and extremism. The algorithm used by the authors let them determine organizational forms and methods of aggregating negative factors, widely spread mechanisms that hinder the peaceful existence of the wider global community. The necessity of conducting a competent and adjusted social policy (educational, domestic, informational), which takes into consideration interests of different social and religious groups, has been stressed. Such policy should be well balanced, intelligently designed, and having financial and logistical support. The research has led to the conclusion that it is disseminating extremist ideology that leads to the growth of terrorist threat and to new terrorist acts themselves. In the article the authors have come to the conclusion that religious extremism should be considered as a regulated social activity of people who are united by religious and political ideology and perform actions directed at changing the established social and political structure.
Towards a Religious Community
Authors:   Irkutsk State University, Smirnov A. E.
Published: March 2022

The purpose of the article is to draw closer to the ontology of a religious community. This need has been justified, theoretical resources have been proposed, based on which a similar ontology can be built. These include the concept of “assemblies”, actor-network theory (B. Latour, M. Kallon, J. Lo), the concept of “community” (M. Blanchot, J.-L. Nancy, J. Agamben). As a result, it is possible to consider a religious community as a binding event, not relying on objectification.
Analisis Hubungan Pendapatan Asli Daerah Dan Dana Perimbangan Melalui Belanja Langsung Terhadap Produk Domestik Regional Bruto
Authors: Vanomy Afrianti Elsye
Published: March 2022

PAD merupakan indikator mengukur tingkat kesuksesan pembangunan di Kabupaten/ Kota dalam pelaksanaan Otonomi Daerah. Otonomi daerah berefek positif untuk daerah yang memiliki potensi Sumber Daya Alam yang kaya. Begitu pula sebaliknya. Contohnya PAD diWilayah Kabupaten Malang mengalami peningkatan dari tahun ke tahun sejak pelaksanaan otonomi daerah. Penelitian ini menggunakan Deskriptif Kuantitatif dengan menyelidiki potensi Pendapatan Daerah, Biaya Langsung yang berefek kepada PDRB di Wilayah Kabupaten Malang. Data rentang waktu 10 tahun (2003 – 2012) serta menggunakan Analisa Jalur. Hasil analisa hubungan untuk komponen Pendapatan yang terdiri dari Dana Perimbangan maupun Retribusi Daerah terhadap Belanja Langsung sebesar 53,45%. Bagi Hasil menduduki posisi teratas. Pendapatan terhadap PDRB sebesar 56,22%, Belanja Langsung terhadap PDRB 23,62%. Jadi komponen Pendapatan berpengaruh kuat terhadap PDRB khususnya Dana Perimbangan, namun syaratnya harus melalui Belanja Langsung dalam pengimplementasian pembangunannya.
Pengaruh Profitabilitas, Struktur Modal, Dan Ukuran Perusahaan Terhadap Nilai Perusahaan
Authors: Febrinita Isfa Rizki Nur
Published: March 2022

Penelitian ini bertujuan untuk menguji dan menganalisis pengaruh profitabilitas (diproksi dengan return on equity), struktur modal (diproksi dengan rasio hutang terhadap ekuitas), dan ukuran perusahaan (diproksi dengan total aset) pada nilai perusahaan (diproksi dengan harga untuk buku nilai) dasar parsial. Populasi penelitian adalah perusahaan-perusahaan dari sektor pertambangan batubara yang terdaftar di Bursa Efek Indonesia pada periode 2012-2015. Metode pengumpulan data adalah purposive sampling, dan jumlah sampel penelitian adalah 18 perusahaan. Data penelitian adalah data sekunder yang diperoleh dari Bursa Efek Indonesia periode tahun 2012-2015. Teknik analisis yang digunakan dalam penelitian ini adalah analisis regresi linier berganda. Pengujian hipotesis penelitian menggunakan uji parsial (uji t) yang didukung oleh SPSS. Hasil penelitian ini menunjukkan bahwa: (1) profitabilitas berpengaruh positif terhadap nilai perusahaan; (2) struktur modal tidak mempengaruhi nilai perusahaan; (3) ukuran perusahaan tidak mempengaruhi nilai perusahaan.
Menganalisa Financial Distress Pada Perusahaan Perdagangan Ritel
Authors: Fajriana Nadia , Kaluge David
Published: March 2022

Penelitian ini bertujuan untuk menguji pengaruh dari rasio profit margin, rasio financial leverage, rasio likuiditas, dan rasio pertumbuhan laba bersih dalam memprediksi adanya kesulitan keuangan pada perusahaan sub sektor perdagangan eceran yang terdaftar di BEI, dengan tahun penelitian 2015-2017. Penelitian ini menggunakan regresi logit. Hasil dari penelitian ini menunjukkan bahwa: (1) Rasio profit margin (laba bersih pada penjualan) berpengaruh positif dalam memprediksi adanya kesulitan keuangan. (2) Rasio financial leverage (hutang lancar pada aset total) tidak berpengaruh dalam memprediksi adanya kesulitan keuangan. (3) Rasio likuiditas (aset lancar pada hutang lancar) tidak berpengaruh dalam memprediksi adanya kesulitan keuangan. (4) Rasio pertumbuhan laba bersih berpengaruh negatif dalam memprediksi adanya kesulitan keuangan. Komponen pada laporan keuangan yang berkaitan dengan rasio profit margin dan rasio pertumbuhan laba bersih memberikan sinyal kepada pengguna laporan keuangan tentang kondisi keuangan perusahaan sub sektor perdagangan eceran.
Kronik lenfositik lösemide tedavi yaklaşımları: Gerçek yaşam verisi
Authors: BANKİR Mehmet , PEPEDİL TANRİKULU Funda , YANARDAĞ AÇIK Didar
Published: March 2022

Amaç: Son yıllarda kronik lenfositik lösemili hastaların yönetiminde pek çok yeni ajan yer almaya başlamıştır. CD20’ye karşı geliştirilen antikorlara; ibrutinib, idelalisib ve venetoclax gibi farklı hedeflere yönelik yeni moleküllerin de eklenmesi ile tedavi algoritmaları hızla değişmiştir. Bu çalışmada, koronavirüs pandemisi öncesi merkezimizdeki kronik lenfositik lösemi tedavi yaklaşımlarının tespit edilmesi amaçlanmıştır. Yöntem: Merkezimizde 01 Ekim 2018 ile 31 Aralık 2019 tarihleri arasında kronik lenfositik lösemi tanısı ile takip edilmiş olan hastalar retrospektif olarak incelenmiştir. Takip ve tedavi verisine ulaşılabilen, 18 yaş ve üzerindeki tüm hastalar çalışmaya dahil edilmiştir. Tanısı kesinleşmemiş olgular, takibi merkezimiz dışında yapılanlar, takip ve tedavi verisine ulaşılamayan olgular ve tedavisi çalışma aralığından önce başlanmış olan hastalar çalışma dışı bırakılmıştır. Tüm datalar hastanemizde hasta takibi için kullanılmakta olan elektronik veri tabanından alınmıştır. Bulgular: Toplam 138 (85 erkek, 53 kadın) hasta çalışmaya dahil edilmiştir. Olguların yaş ortalaması 65 (35-88)’dir. Tedavi almış olan 28 olgu için ileri analizler yapılmıştır. Hastaların %64’ünde birinci basamak tedavi uygulanırken, %32’sinin relaps/refrakter kronik lenfositik lösemi nedeni ile tedavi almakta olduğu görülmüştür. Birinci basamakta en sık uygulanan protokoller bendamustin, rituximab (%39) ve fludarabin, siklofosfamid, rituximab (%33)’ dır. Relaps/refrakter hastalık için tedavi uygulanan hastalarda ise ibrutinib (%78) ve venetoclax (%22) kullanıldığı görülmüştür. Sonuç: Kronik lenfositik lösemili hastalarda birinci basamakta öncelikle rituximab içeren bir kemoimmunoterapi protokolünün tercih edildiği, relaps/refrakter hastaların tamamında ise hedefe yönelik yeni moleküllerin uygulandığı görülmüştür. Mevcut klinik pratiğimiz güncel kılavuzlara paralel olup, yeni moleküllerin geri ödeme koşullarının uygun olduğu tüm hastalarda tercih edilmiş olması, ilerleyen yıllarda kronik lenfositik lösemi tedavi protokollerimizde hedefe yönelik moleküllerin kemoterapinin yerini alacağını düşündürmektedir.
Investigation of the Cytokine Spectrum of Patients' Oral Fluid with Generalized Periodontitis and Metabolic Syndrome
Authors:   Bukovinian State Medical University. 2, Theater Square, Chernivtsi 58002, Ukraine, Нlushchenko T. A.
Published: March 2022

The purpose of the study was to study the state of cytokine regulation of oral fluid in patients with generalized periodontitis and metabolic syndrome. Materials and methods. For this study, 3 groups of surveys were formed. The main group included 30 people with generalized periodontitis on the background of metabolic syndrome; 30 people with generalized periodontitis, without somatic pathology, formed a comparison group. The obtained results were compared with the data of 20 practically healthy individuals with intact periodontium who were included in the control group. The content of pro-inflammatory cytokines IL-1β, IL-6, TNF-α and anti-inflammatory cytokines IL-4, TGF-β1 in the oral fluid of the study groups was determined by solid-phase enzyme-linked immunosorbent assay. Results and discussion. According to the research, on average, the highest levels of pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) were observed in patients with periodontal disease on the background of metabolic syndrome. We investigated increase in the concentration of proinflammatory IL-1β. The average value of IL-6 in the oral fluid of patients with metabolic syndrome exceeded this figure in persons not burdened with somatic pathology by 1.3 times, the difference with healthy individuals was more significant: the indicators differed by 2 times. That can be considered an immune response to the inflammatory process in periodontal tissues. The next stage is the beginning of the cytokine cascade, which is characterized by increased production of IL-6 and TNF-α – inducers of acute phase protein synthesis. TNF-α causes an increase in the number of free radicals and can lead to intensification of apoptosis. Due to the fact that anti-inflammatory IL-4 blocks the induced expression of pro-inflammatory IL-6 and TNF-α, a decrease in its level in oral fluid can be considered an unfavorable factor in the course of inflammatory-dystrophic periodontal lesions in patients with syndrome X. Given that TGF-β1 is an immunosuppressive factor, a decrease in its concentration indicates a deficiency of local factors of immune protection in patients with periodontal disease on the background of metabolic syndrome. Conclusion. Patients with metabolic syndrome and periodontal disease have significant disorders of cytokine regulation, which are complicated by age: expression of proinflammatory IL-1β, IL-6, TNF-α on the background of reduced anti-inflammatory cytokines IL-4 and TGF-β1. Such changes in cytokine homeostasis indicate chronic inflammation, insufficient efficiency of regenerative processes in tooth-retaining tissues, and, as a consequence, lead to a more severe course of periodontal disease in people with metabolic syndrome
Influencia de la vitamina D en el tratamiento de la COVID-19
Authors: Altamirano Pazmiño Laura Isabel , Triviño Muso Karen Dayanara , Moreira Ramírez Fernanda Lissette , Herrera Rodríguez Jessenia Kathiuska
Published: March 2022

La COVID-19 es la enfermedad causada por el nuevo coronavirus conocido como SARS-CoV-2. Cualquier persona, a cualquier edad, puede enfermar de COVID-19 y presentar un cuadro grave o morir. Entre las complicaciones que pueden llevar a la muerte se encuentran la insuficiencia respiratoria, el síndrome de dificultad respiratoria aguda, la septicemia y el choque septicémico, la tromboembolia y/o la insuficiencia multiorgánica, incluidas las lesiones cardíacas, hepáticas y renales. Las respuestas que han dado los diferentes países al enfrentamiento a la pandemia son muy diversas, algunas han sido tardías y otras limitadas, al margen de las orientaciones de los organismos internacionales y del conocimiento científico producido hasta el momento. Es de interés de esta investigación recabar la información pertinente respecto a la influencia de la vitamina D respecto a la enfermedad COVID-19 a través de una revisión bibliográfica apoyada en medios electrónicos de valor científico académico como SCOPUS, PubMed, Biblioteca Cochrane y los repositorios derivados de buscadores de trabajos de investigación como Google Académico. Es bien conocido el efecto de una nutrición adecuada en el sistema inmunitario y esta investigación parte del principio de que la Vitamina D podría tener efecto protector en la infección por COVID-19 por sus acciones inmunomoduladora, antiinflamatoria, antimicrobiana, reguladora del sistema renina-angiotensina-aldosterona, favorecedora de la indemnidad del epitelio respiratorio y la homeostasis redox celular. Se puede asegurar que un esquema de tratamiento con dosis más altas de vitamina D podría usarse en pacientes con COVID-19 y deficiencia confirmada de esta vitamina. El objetivo es mantener las concentraciones de 25(OH)D en plasma entre 40-60 ng/ml. Debido a que los niveles adecuados de VD se han asociado con disminución de la incidencia y severidad de varios virus respiratorios, herpes zóster, hepatitis, Epstein Barr, Ébola, virus de la inmunodeficiencia humana y dengue, los datos encontrados demostrarían que la suplementación con vitamina D podría mejorar los resultados de los marcadores del síndrome de liberación de citocinas que se elevan significativamente en pacientes infectados con SARS-COV-2 y tienen más probabilidades de volverse hipóxicos hasta requerir soporte ventilatorio en las unidades de cuidados intensivos. Sin embargo, son necesarios más estudios clínicos en pacientes para validar esto debido a que los estudios respecto al comportamiento de la enfermedad COVID-19 aún se desarrollan y por tanto se mantienen los estudios y hallazgos.
Tecnología de Realidad Aumentada en el Inter - Aprendizaje
Authors: Chicaiza Vinueza Victor Javier , Padilla Gómez Renzo Rogelio , Chicaiza Guayta Silvia Maria , Guanoluisa Paredes Luis
Published: March 2022

La presente investigación realizó el análisis de las repercusiones que sobre el Inter– aprendizaje tiene la implementación de la Realidad Aumentada en el aula de clase de los estudiantes de Segundo de Bachillerato de Colegio Fiscal 17 de septiembre del Cantón Milagro. Abordó los fundamentos teóricos referentes a las dos variables. Presentó las ventajas y la aplicabilidad de la realidad aumentada con otras áreas. Se aplicó una investigación descriptiva para determinar los factores que inciden en el mejoramiento del aprendizaje participativo en el aula de clase. Su aplicación obtuvo grandes beneficios al aplicar una guía práctica y didáctica como apoyo educativo que fue seguida por los estudiantes. La investigación logró demostrar cómo la aplicación de realidad aumentada generó un interés especial por aprender, motivó la participación de todo el grupo de trabajo y facilitó la aprehensión del conocimiento
Incidencia de las infecciones vaginales en embarazadas de la consulta externa del Hospital General Guasmo Sur desde septiembre 2018 – febrero 2019
Authors: Rodríguez Landívar Gabriela Alexandra , Quinteros Pacheco Linda Stefania , Luna Rodríguez Hugo Antonio
Published: March 2022

Como ya sabemos la mujer en estado de gestación es muy vulnerable a padecer cualquier infección vaginal causada por distintos microorganismos: levaduras, bacterias, parásitos. Este estudio es de tipo prospectivo, su objetivo principal determinar la incidencia de la infección vaginal más frecuente en las mujeres embarazadas, una vez que se tenga el diagnostico establecido dar su debido tratamiento con el fin de evitar complicaciones durante el embarazo y el parto. La población que se estudió corresponde a las pacientes de la consulta externa del Hospital General Guasmo Sur durante los meses de septiembre 2018- febrero 2019. Dando un total de 100 pacientes, con edades entre los 16 a 45 años. Se obtiene los resultados el microorganismo más frecuente con una incidencia alta 40% de candidiasis vaginal, también obtuvimos las edades en donde hay mayor incidencia de infecciones que son entre los 21- 25 años 41%. Se recomienda promover y prevenir la incidencia de infecciones vaginales en las mujeres estén o no estén embarazadas en todas las unidades médicas posibles para llevar un embarazo sin complicaciones futuras.
Síndrome de Mirizzi
Authors: Macías Sabando María Matilde , Magallanes Vera Natasha Carolina , Magallanes Vera Yahaira Arlet , Baquerizo Godoy María Fernanda
Published: March 2022

La enfermedad de vía biliar es una de las patologías más frecuentes en el servicio de Cirugía. El Síndrome de Mirizzi (SM) es una de las complicaciones poco frecuente de estas patologías, más frecuente en países en vías de desarrollo, alcanzando en Latinoamérica. El SM se produce a causa de uno o varios cálculos impactados en el cuello de la vesícula o el conducto cístico, lo que condiciona compresión extrínseca y obstrucción del conducto hepático común produciendo una reacción inflamatoria, y condicionando estenosis del conducto hepático común. Con el fin de exponer los elementos resaltantes referidos de este síndrome poco común se expone una revisión bibliográfica de los hallazgos y actualizaciones científicas publicadas a la fecha. Se excluyeron los resultados de exposición de casos clínicos, las publicaciones de antes del 2016 y las que no estuvieran en español. Las manifestaciones clínicas y los hallazgos de laboratorio del SM son muy inespecíficos y desafortunadamente no cuenta con signos patognomónicos. Los pacientes pueden aquejar dolor típico cólico o manifestarse con los síntomas sistémicos de la fiebre, como: escalofríos, taquicardia y anorexia. Los hallazgos de laboratorios más frecuentes, son la elevación de fosfatasa alcalina y bilirrubina. Presenta una incidencia de menos del 1%, la incidencia de esta patología aumenta con la edad, sin embargo, no tiene predilección por razas. El diagnóstico preoperatorio puede ser difícil, caso contario es esencial el reconocimiento intraoperatorio y un manejo adecuado para evitar la alta incidencia de lesión de la vía biliar. El tratamiento de los pacientes afectos de SM infiere dificultades técnicas complejas, comparado con la terapéutica de la enfermedad litiásica vesicular no complicada. El objetivo del tratamiento incluye la descompresión de la vía biliar y prevenir la recurrencia de la afección. El pronóstico del MS es muy bueno para las lesiones tipo I. Sin embargo, el tratamiento de lesiones más serias con destrucción fistulosa de la VBP, aumenta la morbilidad postoperatoria en 10 % o más, incluyendo fistulas biliares, estenosis de la VBP, abscesos de vecindad; que demandarían reintervenciones con el incremento consecuente de la morbimortalidad.
Reproductive potential and histological profiling of the wild female anadromous shad (Tenualosa ilisha) in lower Meghna Estuary, Bangladesh
Authors: Akhter Mousumi , Khan Abu Bakker Siddique , Ullah Md. Rahamat
Published: March 2022

Hilsha shad (Tenualosa ilisha, Hamilton 1822) is the most commercially important and national fish of Bangladesh, belongs to the family of Clupeidae of the Clupeiformes. The study was conducted to identify the seasonal gonadal cycles through histological study and the peak breeding season combining histological and Gonado Somatic Index (GSI). One hundred and twenty fish samples with an average weight of 756.75±6.25 g was collected from the Tentulia river for the study throughout the year. Monthly mean GSI values of females ranged from 6.36±0.69 to 15.02±1.33. The lowest mean GSI value was found in December and the highest GSI value was in October. From the histological observation of the ovary, early perinucleolar stage, late perinucleolar stage, yolk vesicle stage, yolk granule stage, pre-mature and mature stages were identified. The highest percentage (75%) of mature oocytes and peak breeding season were observed in October and the breeding season continues from October to November. These results will be helpful for fishery managers to impose adequate regulations for sustainable fishery management in Bangladesh.
A review on comparative effect of chemicals and botanicals in management of brown spot diseases of rice (Oryza sativa L.)
Authors: Parajuli Monika , Khadka Gautam Bahadur , Chaurasia Jay
Published: March 2022

Brown spot of rice is a fungal disease caused by either Bipolaris oryzae, Helminthosporium oryzae or Drechslera oryzae species, which is found to be a major problem eventually causing sustainable losses both in quality and quantity. The pathogen after infection shows the symptoms on the leaves, panicles, glumes, and grain causing first as small, circular, and dark brown to purple-brown spots and fully developed lesions are circular to oval with a light brown to gray center, surrounded by a reddish-brown margin and ultimately killing the leaf. We have collected our information from secondary sources. In this review article, we have discussed the effects of bio-agents and chemicals and their comparative efficacy. Fungicides like: propiconazole, Carbendazim, Mancozeb, Hexaconazole, Cabendazim, Bion, Amistar, Tilt etc. are discussed which showed diverse performance on the diseases brown spot of rice. Extracts from the plant parts like roots, stem, leaves etc. are comparatively analyzed and studied that effected on mycelial growth and spore germination of Bipolaris pathogen. The plant components with phenolic structures like carvacrol, eugenol, and thymol are found to be highly active against the pathogen. The extracts of plants like Azadirachta indica, Nerium oleander, Curcuma longa, S. indicum, Cymbopogon citratus etc. are found suitable against brown spot in rice. Chemical fungicides were found to have more inhibition rate against the pathogen, even up to 100%. Although being eco-friendly, plant extracts were recorded to be less effective in comparison to chemical fungicides for suppressing plant pathogen. This article promotes the use of plant extracts for human health and environmental benefits over the use of chemicals for the control of plant diseases.
Existing agroforestry practices and their contribution to the socio-economic condition of the people of west Nawalparasi, Nepal: A case study
Authors: Pokharel Sindhu , Bhattarai Sanjeeb , Adhikari Rabindra , Jha Suveksha , Pokhrel Aaradhana , Parajuli Madhavi
Published: March 2022

The modern agroforestry systems have the potential to improve livelihood through the production of food, fodder, and firewood as well as mitigation of the impact of climate change. Therefore, it's high time to study local people's perception towards agroforestry adoption and suggest potential agroforestry practices and their benefits for the upliftment of their livelihood. This research was conducted in Susta rural municipality, Pratappur rural municipality, and Bardaghat municipality of Nawalaparasi (West) district to explore the existing agroforestry practices followed by the people, its contribution to the economy of households, to understand the people's perception/attitude towards its adoption and finally to propose the potential agroforestry practices. Primary data were collected using Participatory Rural Appraisal (PRA) tools and secondary information through journals and reports. The analysis begins with distinguishing agroforestry systems and practices, preference of trees, benefits through these practices, people's perception, and problems regarding these practices. A total of 39 tree species and 30 food crop species were planted by 282 household people surveyed. Mangifera indica (relative prevalence 25.92%) is the most predominant fruit species whereas Dalbergia sissoo (relative prevalence 21.28%) is the most predominant timber species. It was found that the boundary planting pattern of the agroforestry system is most (40%) used by farmers of Parasi. The result demonstrated that agroforestry aids in the improvement of livelihood. Nevertheless, respondents have experienced increment incidences of pests and diseases to the annual crops and trees. Hence, the provision of training to improve the skills and knowledge of households seem to be the major need to flourish the agroforestry practices.