bluuebunny/crossref_metadata_2025 huggingface dataset:
General Practitioner Use of e-Consultation to Consult Hospital Specialists: Interview Study to Obtain Physician’s Perceptions About Digital Interprofessional Communication
Authors: Peeters Ken , Giroldi Esther , Veldhuizen Lotte , Abdelaziz Kahin , Muris Dennis , Cals Jochen
Published: March 2023

Background

In recent years, tasks have shifted from specialized hospital care to primary care, leading to both advantages and challenges for general practitioners (GPs). A frequently mentioned tool to face these challenges is e-consultation, a form of asynchronous digital interprofessional communication between GPs and hospital specialists.

Objective

The objective of this study was to gain insight into GPs’ and hospital specialists’ views and experiences of e-consultation.

Methods

We interviewed 47% (15/32) GPs and 53% (17/32) hospital specialists and performed a thematic analysis.

Results

We found that both GPs and hospital specialists experience a positive effect on the quality of care and collaboration between GPs and hospital specialists. Positive effects were reported on the accessibility of care, efficiency of care, and relationship between the GP and the patient. Furthermore, communication between GP and hospital specialist became more efficient, and e-consultation offered educational value for the GP. Certain improvements are needed to further optimize e-consultation, regarding applicability, communication, and training purposes.

Conclusions

In the future, clinicians and policy makers can use the insights gained from this study to further optimize and implement e-consultation in clinical practice.
Use of Rapid Antigen Tests to End Isolation in a University Setting: Observational Study
Authors: Zigo Liliana , Wilkinson Alyson , Landry Megan , Castel Amanda D , Vyas Amita , McDonnell Karen , Nagaraj Nitasha Chaudhary , Goldman Lynn R
Published: March 2023

Background

COVID-19 isolation recommendations have evolved over the course of the pandemic. Initially, the US Centers for Disease Control and Prevention required 10 days of isolation after a positive test result. In December 2021, this was reduced to a minimum of 5 days with symptom improvement, followed by 5 days of mask wearing. As a result, several institutions of higher education, including the George Washington University, required persons testing positive for COVID-19 to either submit a negative rapid antigen test (RAT) with symptom resolution to leave isolation after 5 days or to maintain a 10-day isolation period in the absence of a negative RAT and the presence of continued symptoms. RATs are tools that can be used both to shorten isolation periods and to ensure that persons testing positive for COVID-19 remain in isolation if infectious.

Objective

The purpose of this analysis is to report on the experience of implementing RAT policies, examine the number of days that isolation was reduced via RAT testing, determine the factors that predicted uploading a RAT, and determine RAT positivity percentages to illustrate the utility of using RATs to end isolation.

Methods

In this study, 880 individuals in COVID-19 isolation at a university in Washington, DC, uploaded 887 RATs between February 21 and April 14, 2022. Daily positivity percentages were calculated, and multiple logistic regression analyses examined the odds of uploading a RAT by campus residential living status (ie, on or off campus), student or employee designation, age, and days in isolation.

Results

A total of 76% (669/880) of individuals in isolation uploaded a RAT during the study period. Overall, 38.6% (342/887) of uploaded RATs were positive. Uploaded RATs were positive 45.6% (118/259) of the time on day 5; 45.4% (55/121) on day 6; 47.1% (99/210) on day 7; and 11.1% (7/63) on day 10 or beyond. Adjusted logistic regression modeling indicated cases living on campus had increased odds of uploading a RAT (odds ratio [OR] 2.54, 95% CI 1.64-3.92), whereas primary student affiliation (OR 0.29, 95% CI 0.12-0.69) and days in isolation (OR 0.45, 95% CI 0.39-0.52) had decreased odds of uploading a RAT. Of the 545 cases with a negative RAT, 477 were cleared prior to day 10 of their isolation due to lack of symptoms and timely submission, resulting in a total of 1547 days of lost productivity saved compared to all being in isolation for 10 days.

Conclusions

RATs are beneficial, as they can support a decision to release individuals from isolation when they have recovered and maintain isolation for people who may still be infectious. Future isolation policies should be guided by similar protocols and research to reduce the spread of COVID-19 and minimize lost productivity and disruption to individuals’ lives.
Duration of Protection From Pneumonia After Pneumococcal Vaccination in Hemodialysis Patients (DOPPIO): Protocol for a Prospective Multicenter Study
Authors: Mellinghoff Sibylle , von Gersdorff Gero , Bruns Caroline , Albus Kerstin , Dimitriou Vassiliki , Steinbach Angela , Schaller Mathias , Vehreschild Jörg Janne , Cornely Oliver A , Liss Blasius Janusch
Published: March 2023

Background

Pneumonia is a leading cause of death in patients with end-stage chronic kidney disease treated with dialysis. Current vaccination schedules recommend pneumococcal vaccination. However, this schedule disregards findings of rapid titer decline in adult hemodialysis patients after 12 months.

Objective

The primary objective is to compare pneumonia rates between recently vaccinated patients and patients vaccinated more than 2 years ago. As an exploratory objective, antipneumococcal antibody titers in hemodialysis patients will be determined as a function. Factors influencing antibody kinetics will be identified.

Methods

Within this prospective multicenter study, we aim to compare 2 strata of vaccinated patients: those recently vaccinated and those vaccinated more than 2 years ago. A total of 792 patients will be enrolled. Twelve partner sites (within the German Centre for Infection Research [DZIF]) with allocated dialysis practices participate in this study. All dialysis patients who are vaccinated against pneumococcal infection in accordance with Robert Koch Institute guidelines prior to enrollment will be eligible. Data on baseline demographics, vaccination history, and underlying disease will be assessed. Pneumococcal antibody titers will be determined at baseline and every 3 months for 2 years. DZIF clinical trial units coordinate titer assessment schedules and actively follow-up on study patients for 2-5 years after enrollment, including validation of end points of hospitalization, pneumonia, and death.

Results

The study has enrolled 792 patients and the last follow-up has been completed. Currently, the statistical and laboratory analyses are ongoing.

Conclusions

Results will increase physician adherence to current recommendations. Establishing a framework for the efficient evaluation of guideline recommendations through a combination of routine and study data will inform the evidence base for future guidelines.

Trial Registration

ClinicalTrials.gov NCT03350425; https://clinicaltrials.gov/ct2/show/NCT03350425

International Registered Report Identifier (IRRID)

DERR1-10.2196/45712
Virtual First Emergency Medicine Visits: The Future of Convenient and Efficient Emergency Care (Preprint)
Authors: Sakumoto Matthew
Published: March 2023

UNSTRUCTURED

The COVID-19 pandemic has led to increased patient volumes, staff shortages, and limited resources in emergency departments, resulting in the rapid acceleration of telemedicine in emergency medicine. The virtual first (VF) program connects patients with emergency medicine clinicians via synchronous virtual video visits, reducing unnecessary emergency department visits and diverting patients to appropriate care settings. VF video visits can improve patient outcomes by providing early intervention for acute care needs and can enhance patient satisfaction by providing convenient, accessible, and personalized care. However, challenges include the lack of physical examination, clinician telehealth training and competencies, and the requirement for a robust telemedicine infrastructure. Additionally, digital health equity is important to ensure equitable access to care. Despite these challenges, the potential benefits of VF video visits in emergency medicine are substantial, and this study is a strong step in building the evidence base for these advancements.
Tsunami Hazard Analysis in Likupang Tourism Area, North Sulawesi
Authors: Saputri Febriani , Angmalisang Ping Astony , Pelle Wilmy Etwil , Manembu Indri , Rumengan Anton , Bara Robert , Sumilat Deiske
Published: March 2023

The Likupang area, North Sulawesi is one of the super priority tourist destinations launched by the Central Government with the marine tourism sector as the axis. On the other hand, the potential for natural disasters originating from the sea is unavoidable so it needs to be one of the considerations in the process of developing disaster-responsive tourist areas. A tsunami hazard analysis study is first step in disaster mitigation planning. The study is in the form of tsunami modeling by identifying the worst possible scenario in the Likupang area using COMMIT modeling. The modeling is able to produce parameters such as arrival time, maximum height and tsunami inundation area. These three parameters are used as the basis for mapping the tsunami hazard map. The modeling produces the fastest arrival time, which occurs in the first minute after an earthquake occurs. The maximum height obtained from the modeling is 6.8 meters. The maximum inundation area reached by the tsunami wave is 23.57 km2. The combined results of the five scenarios are presented in hazard maps. The majority of public tourist sites are in the Warning status area, but some private resorts are still in the area with the Major Warning status.
Using the linear damage summation hypothesis in determining the endurance limit of titanium alloy
Authors: A. Skvortsov Arkadiy , O. Gnatyuk Evgeniya , Sklemina Olga Yu , K. Nikolaev Vladimir
Published: March 2023

The presented paper is relevant, as it presents the results of fatigue tests of titanium alloy. The purpose of the article is to describe the use of the hypothesis of linear damage summation when processing the results of fatigue tests. In the study, the authors used empirical methods such as indirect observation of the object under study, description, and measurement of technical influences exerted on it by an artificial means. The linear regression analysis to establish the relationship between stress and durability was also used. The endurance limit of the titanium alloy was determined, which lies in the range from 460 to 480 MPa with the number of cycles from 105 to 108. It was concluded that the use of the linear damage summation hypothesis in processing the results of fatigue tests entails a satisfactory practical accuracy of the calculation of endurance limit
Single-Stage Reconfigurable Single-Phase Inverter Topology for Grid-Tied Solar Photovoltaic System
Authors: Sudhakar Mr. Wavhal Shashwat , Bagale Prof. L. V.
Published: March 2023

Abstract: This study proposes a new topology for a single-stage 1-ph inverter used in grid-connected solar PV systems. By using this topology, the need for a DC-DC converter is eliminated, which leads to higher efficiency and lower cost. The inverter is capable of operating in three different modes based on input voltage and grid voltage conditions. A control algorithm determines these conditions. Results from simulations and experiments demonstrate the effectiveness of the proposed topology in terms of efficiency, power quality, and performance under various operating conditions. This new topology shows promise for creating cost-effective and high-performing grid-connected solar PV systems.
Análisis del decrecimiento de los derrames de los ríos Limay y Chubut
Authors: Poblete, Arnobio Germán , Albeiro Castro María Agustina
Published: March 2023

Teniendo en cuenta los reportes emitidos por los modelos de pronósticos de largo plazo de los grandes centros internacionales sobre la región del Comahue y Patagonia, que coinciden en proyectar para el período 2080–2100 una importante disminución de las precipitaciones invernales en la misma, en este trabajo se verifica si el comportamiento actual de sus principales ríos es compatible con dichos pronósticos.

Sin embargo, una de las mayores dificultades que presenta el estudio del cambio climático en dichas regiones, es la escasez de series climatológicas e hidrológicas lo suficientemente largas en el período instrumental como para aplicarles test estadísticos de detección de tendencias y saltos en la media.

Siendo el río Limay el más representativo de la primera región y el Chubut de la segunda, dado que cuentan con mediciones regulares de caudales incompletas y/o con datos faltantes, se los seleccionó para extender y optimizar sus series temporales obteniendo valores estimados de periodos anteriores/posteriores desde el inicio de sus respectivas mediciones y así hacer posible la detección aludida, entre otros propósitos. 

La reconstrucción de los datos de los derrames anuales (volumen de agua aportado en una temporada) de dichos ríos se realizó mediante modelos estadísticos empíricos no lineales. Se logró uno que muestra una muy buena performance estadística y retrotrae las estimaciones del derrame de sendos ríos.

Se dispone, en la actualidad, para el río Limay de una serie medida de 115 años, mientras que el Chubut, tiene una incompleta. De ahí que se hará uso de las mediciones del primero para reconstruirlo. A su vez, a éste último, se lo emplea para actualizar la serie del primero desde 2011 hasta 2017.

Una vez lograda la reconstrucción de sus series, resultó viable un análisis de tendencia y detección de cambios abruptos con el objeto de describir estadísticamente la estructura del decrecimiento de sus derrames que se verifica hasta el presente.
Relato de Experiencia: La democracia como contenido escolar. Alcances, perspectivas y problemas para la práctica docente
Authors: Baez Fabián , Belforte Dante
Published: March 2023

En el marco de la investigación radicada en la Universidad Nacional de la Patagonia Austral – Unidad Académica Río Turbio (en adelante UNPA-UART), nos proponemos indagar a partir de reflexiones personales enmarcadas en posibles relatos y vivencias profesionales, acerca de cómo desde la formación docente se favorece que los futuros docentes se apropien de herramientas, no solo conceptuales, sino también a nivel de estrategias para la reflexión con otros, en la construcción de los conocimientos de las Ciencias Sociales.

En particular, desde la cátedra de Formación Ética y Ciudadana del Profesorado para la Educación Primaria e Inicial de la UNPA-UART, buscamos estudiar los procesos de construcción y significación de los contenidos escolares, que encierran en su seno aspectos intrínsecos de socialización social, siendo conveniente el abordaje de democracia como contenido escolar para entender la experiencia de las alumnas del profesorado de ambas carreras en relación a su tratamiento.

Como objetivo primordial pretendemos indagar y pensar de qué manera los contenidos curriculares que, en su comprensión, incluye una serie de aspectos abstractos concernientes a interpretar significados relacionados a la democracia. Esta propuesta de investigación es también interpretar su actualización disciplinar para el proceso de su enseñanza y por lo tanto, sirvió de guía para un trabajo de campo con alumnas de ambos profesorados, centrado esencialmente en la pregunta qué y cómo abordar democracia como contenido escolar.
Régimen académico y acompañamiento al estudiantado en escuelas secundarias de Zona Norte de la Provincia de Santa Cruz
Authors: Almada María Laura
Published: March 2023

Uno de los ejes vertebradores de la Ley de Educación Nacional (LEN) N° 26. 206/2006 es el logro de mayor igualdad en todo el sistema educativo. Para ello, la obligatoriedad aparece como la principal novedad en las políticas sobre el nivel secundario (Gorostiaga, 2012) y un conjunto de políticas que acompañan ese proceso.

A partir de la LEN, cada provincia estableció los lineamientos políticos que consideraba más específicos para atender al  eje de la igualdad. En tal sentido, en la Provincia de Santa Cruz, además de la Ley de Educación Provincial N° 3305, se estableció en el año 2014, una nueva organización pedagógica, establecida en el régimen académico de educación secundaria (Acdo. 075/14 Consejo Provincial de Educación (CPE). El concepto de “régimen académico” como lo plantean Baquero et al. (2009) es una construcción que sistematiza aspectos significativos de la experiencia escolar que deben seguir los miembros de las escuelas secundarias. Partimos de la consideración de Camilloni (1991), que entiende al régimen académico como el conjunto de regulaciones sobre la organización de las actividades de los/las estudiantes y sobre las exigencias a las que estos deben responder.

En el estudio que aquí presentamos, interesa describir las dinámicas de puesta en acto (Ball, Maguire & Braun, 2012) del régimen académico a nivel de las escuelas. Sostenemos que las políticas pueden ser incorporadas en las instituciones sin generar cambios significativos o concretos o pueden llegar a generar cambios en ocasiones no intencionados. Como lo expone Ball (1994), las políticas educativas son interpretadas por cada escuela, lo que lleva a modos de trabajo diferentes, debido a las particularidades de cada contexto.

Consideramos que un factor relevante en la puesta en acto de las políticas educativas es el contexto puesto que, como lo plantean Ball, et al. (2012), se deben considerar las condiciones “objetivas” y la interpretación de éstas de maneras “subjetivas”. Ello porque los recursos, ya sean materiales, estructurales o relacionales, influyen en la interpretación que se realice de las políticas.

El régimen académico, al decir de Baquero et al. (2009), no se trata de un instrumento presente en la tradición escolar sino de un constructo que se ha hecho necesario en virtud de la complejidad del entramado de regulaciones explícitas y tácitas que estructuran la experiencia y afectan la trayectoria escolar.
Los servicios de salud sexual y reproductiva para los/as adolescentes en tiempos de pandemia. El caso de la Municipalidad de Caleta Olivia
Authors: Roldán Sandra , Guerra Lía
Published: March 2023

El presente informe tiene por objeto presentar los resultados del proyecto de investigación que da título al artículo, cuyo propósito fue la caracterización del acceso a los servicios de Salud Sexual y Reproductiva (SSyR)  por parte de los/as adolescentes en la zona sur oeste -territorio de mayor desigualdad social- en la ciudad de Caleta Olivia, habida cuenta de las restricciones imperantes en tiempos de cuarentena. Apenas iniciada la pandemia, organismos internacionales como el Fondo de Población de las Naciones Unidas (UNFPA) advirtieron sobre las interrupciones en la atención a los/as adolescentes y particular en la cadena de suministro de anticonceptivos, previendo incluso 7 millones más de embarazos no planeados. Atendiendo a este escenario, este proyecto de investigación (enmarcado en el programa de Políticas Sociales de la UNPA) junto a la Secretaría de Juventud y, particularmente el CIJ (Centro Integrador Juvenil) de la Municipalidad de Caleta Olivia (MCO) se propuso caracterizar y generar nuevas estrategias en la provisión de los servicios de SSyR, con objeto de contribuir al diseño de mecanismos sustentables en la pospandemia.

De ese contexto surgen los resultados relativos a: a) el relevamiento del uso de los medios digitales por parte de los sectores municipales involucrados en la prestación de dichos servicios a adolescentes, b) la propuesta de diseño de una aplicación móvil que no solo brinde información relativa a SSyR sino que resulte un canal de acceso directo a los servicios prestados por el municipio.
La gestión del talento humano con base en la innovación y con influencia de la cultura organizacional empresaria. El caso de las PyMES de Río Gallegos
Authors: Martínez Llaneza Daniel , Lucero Jessica
Published: March 2023

Los recursos humanos son considerados un factor valioso y estratégico para las empresas del ámbito local. Por tanto, su inclusión en la función de producción empresaria, asume una consideración ineludible para la generación de ventajas competitivas sostenibles y sustentables que favorezcan la adaptación de las organizaciones al dinamismo del mercado, innovando en las estrategias de negocios. El paradigma de la Gestión Estratégica de Recursos Humanos (GERH), considera al personal que forma parte de la organización, el factor decisivo para la competitividad. La irrupción tecnológica como vector de innovación, impacta de manera transversal a las organizaciones y sus procesos, redefiniéndolos hacia la obtención de resultados más efectivos. El objetivo de este estudio fue identificar los modos en que se promueven, construyen y gestionan los procesos de innovación a través de la gestión del talento humano y de qué manera se transforma la cultura organizacional de las empresas Pymes radicadas en la ciudad de Río Gallegos. Los resultados evidencian un desarrollo incipiente de prácticas profesionalizadas en la gestión de los recursos humanos y una tendencia hacia la implementación de procesos innovadores predominantemente, en el sector servicios. Estos resultados evidenciaron una perturbación importante ante la irrupción de la pandemia por Covid-19, que también se refleja en la información recopilada.
Basic hydrogel polymer materials for 3D printing
Authors: Findrik Balogova Alena , Trebunova Marianna , Mitrik Lukas , Hudak Radovan , Zivcak Jozef
Published: March 2023

Currently, 3D printing of hydrogel scaffolds, which are used in tissue engineering to come to the fore, is gaining prominence in order to restore the structure and function of soft tissues and organs. For successful printing of soft constructs, the FRESH method using a support bath is used, thanks to which the printed hydrogel is kept in the desired shape during solidification. The aim of the study is to create an overview of hydrogel materials and their properties affecting printing, to summarize previous printing of hydrogel scaffolds. The choice of material, the method of crosslinking for the formation of the hydrogel, is taken into account, while at the same time the non-toxicity and compatibility of the material with the biological environment. Specific emphasis is placed on adapting the technological procedure of the FRESH method, where the chemical composition of the support bath must be in accordance with the crosslinking agent and the rheological properties of the printed hydrogel.
Consideraciones clínico-legales para acceder a la esterilización quirúrgica femenina: Chile en el contexto internacional (2014 - 2020)
Authors: Martínez Macarena , Arenas-Verdugo Fernanda , Asencio-Carrillo Catalina , Lugo-Berrios Louisiana , Rosas-Viligron Camila , Soto-Mansilla Danya , Velásquez-Mansilla Catalina , Yakich-Goregoitía Carolina
Published: March 2023

Objetivo: determinar las consideraciones clínicas y legales para acceder voluntariamente a la esterilización quirúrgica femenina en Chile, en el contexto internacional que va entre los años 2014 y 2020.
Metodología: revisión sistemática narrativa. Se realizó una búsqueda en las bases de datos Scielo, Pubmed, Elsevier y Dialnet Plus utilizando los términos esterilización quirúrgica femenina, esterilización quirúrgica en mujeres, anticoncepción permanente, esterilización femenina permanente, acceso y legislación.
Resultados: se obtienen 19 artículos para análisis. La técnica más utilizada para la realización del procedimiento es la salpingectomía con oclusión ovárica. Se identifican barreras de acceso burocráticas, legales y tiempos de espera, información y conductas profesionales que limitan a las mujeres que optan por este método de planificación familiar en todos los países analizados.
Conclusión: existen factores modificables y no modificables dentro de las consideraciones clínico-legales. Los primeros incluyen las conductas de los profesionales de la salud, y la información que se otorga a las mujeres para que logren una participación más activa dentro del proceso de decisión. Es en este punto donde la matronería debe relevar su rol
The Return of the Forgotten Writer: the First Academic Edition of the Legacy of Kokhanovskaya (N. S. Sokhanskaya)
Authors:   Petrozavodsk State University, Kunilsky Andrey E.
Published: March 2023

The report provides information about the publication of the first two volumes of the Complete Works and Letters of Kokhanovskaya (N. S. Sokhanskaya). It tells about the forgotten writer and her return to readers and researchers, made largely thanks to the efforts of O. L. Fetisenko — leading research fellow of the Institute of Russian Literature (Pushkin House) of the Russian Academy of Sciences. The author of the message traces the history of scientists’ appeal to the heritage of Kokhanovskaya, briefly reviewes the content and composition of the two published volumes of the complete works and indicates the immediate plans of the publishers, indicated by them earlier.
Acute and Subacute Cardiovascular Effects of Synthetic Cannabinoid JWH-018 in Rat
Authors: Ozhan Onural , Ermis Necip , Celbis Osman , Samdanci Emine , Petekkaya Semih , Oruc Mucahit , Soylu Ozcan , Koparir Pelin , Acet Ahmet , Parlakpinar Hakan
Published: March 2023

The use of JWH-018, which is among the abused bonsai in the world and in
our country due to its psychostimulant effect, is increasing day by day.
Here, we evaluated the pharmacologic, cardiologic, biochemical, and
histopathological effects of acute and subacute administration of low
and high doses of JWH-018 in rats. The concentrations of JWH-018 and its
metabolites in the heart were analyzed by liquid chromatography-mass
spectrometry. JWH-018 administration caused many cardiac pathologies
including dysregulation of the heart rate, and low blood pressure, also
induced cardiac arrhythmia, branch blocks, and ischemic ECG changes
depending on the drug dosage and the duration of treatment.
Echocardiography did not show any significant structural or functional
changes among the groups. The level of serum pro-brain natriuretic
peptide which is an indication of impaired cardiac capabilities become
observed to be elevated in a long-time excessive dose JWH-018 used
group. Histopathologic findings consistent with acute myocardial
ischemia were detected in the hearts of all groups. Loss of cross-talk
of myocardial fibrils, and prominent eosinophilic contraction bands were
early signs of acute myocardial infarction (4th and 12th hours), which
were more common in subacute groups and associated with ischemia. Desmin
staining was observed as increased in subacute groups and there were
marked contraction band dyneins. There is growing pharmacological and
pathological evidence of impairment, cardiac effects, and tissue injury
attributable to this emerging class of drugs.
Corollary discharge function in healthy controls: evidence about self-speech and external speech processing.
Authors: Beño-Ruiz-de-la-Sierra Rosa M. , Arjona Antonio , Estevez Sabela Fondevila , Fernández-Linsenbarth Inés , Diez Alvaro , Molina Vicente
Published: March 2023

As we speak, corollary discharge mechanisms suppress the auditory
conscious perception of the self-generated voice in healthy subjects.
This suppression has been associated with the attenuation of the
auditory N1 component. To analyze this corollary discharge phenomenon
(agency and ownership), we registered the Event-Related Potentials of
forty-two healthy subjects. The N1 and P2 components were elicited by
spoken vowels (talk condition; agency), by played-back vowels recorded
with their own voice (listen-self condition; ownership), and by
played-back vowels recorded with an external voice (listen-other
condition). The N1 amplitude elicited by the talk condition was smaller
compared to the listen-self and listen-other conditions. There were no
amplitude differences in N1 between listen-self and listen-other
conditions. The P2 component did not show differences between
conditions. Additionally, a peak latency analysis of N1 and P2
components between the three conditions showed no differences. These
findings corroborate previous results showing that the corollary
discharge mechanisms dampen sensory responses to self-generated speech
(agency experience), and provide new neurophysiological evidence about
the similarities in the processing of played-back vowels with our own
voice (ownership experience) and with an external voice.
Analysis of the detection of Epstein-Barr Virus (EBV) DNA of specimens from different sources in Beijing, China
Authors: Sun Kuixia , Wu Xian , Sun Liying , Huang Lei
Published: March 2023

Objective: To explore the positivity of EBV DNA from different
disease departments and different sample types in Beijing, China and to
help clinicians to choose the appropriate specimens for detection.
Methods: A retrospective study was performed on EBV DNA
detection by quantitative real time PCR (qPCR) between 2015 and 2021.
Data from total 5494 samples were collected. According to the results of
EBV DNA detection, the positivity was analyzed by the age, gender, the
types of specimens and different clinical departments respectively.
Results: Of 5494 samples, the positivity detection rate of EBV
DNA was 13.65%. The positivity of EBV DNA in male patient was higher
than that of female patient samples (14.87% vs 12.07%,
p=0.003). The positivity of EBV DNA in adult samples was higher
than that of pediatric samples (14.58% vs 11.71%, p=0.004).
Pediatrics at 3-6 years had the highest EBV DNA positivity rate
(17.77%) among all pediatric samples. Adults aged 40-50 years has the
highest EBV DNA positivity rate (17.50%) among all adult samples.
Pediatrics samples from department of Pediatric Hematology had the
highest EBV DNA positivity rate (36.36%), followed by that of Pediatric
Infection Department (23.23%). Among adult group, the EBV DNA
positivity was detected highest in department of Hematology (26.27%),
followed by department of Dermatology (21.05%). Of all samples, EBV DNA
was detected positively mostly in lymphocyte (48.04%) and respiratory
tract specimens (36.00%), which were much higher than those of serum
samples (5.58%) ( p<0.05). Conclusions: EBV
DNA test should pay more attention in 3-6 years children and 40-50 years
adults, especially patients with hematological diseases. Besides, in
order to improve the detection rate of EBV DNA, specimens such as
lymphocyte and respiratory tract specimens may be collected as a
priority selection according to disease.
Effect of anti-rheumatic drugs on the clinical outcome of autoimmune rheumatic diseases patients infected with COVID-19: A systemic review and meta-analysis
Authors: Su Qin-Yi , Zhang Sheng-Xiao , Luo Jing , Cheng Ting , Zhang He-Yi , Zhang Yan , Zhao Bing-Ru , Gao Chong , Wang Cai-Hong
Published: March 2023

The immune deregulation and disease-modifying anti-rheumatic drugs
(DMARDs) make patients with autoimmune rheumatic diseases (ARD) more
susceptible to infection. We aimed to investigate the prevalence and
clinical outcome of COVID-19 in ARD patients with different treatments.
PubMed, Embase, Medline, Cochrane Library, Web of Science were searched
to identify the relevant evidence up to March 20, 2023. The overall
prevalence of COVID-19 in ARD patients was 0.061. The ARD patients with
glucocorticoids (GC) treatment had the highest
prevalence[0.088(95%CI:0.065-0.110)] compared to biological (b)
DMARDs[0.041(95%CI:0.031-0.051)], conventional synthetic (cs)
DMARDs[0.055(95%CI:0.043-0.067)], and anti-TNF
therapy[0.029(95%CI:0.003-0.056)]. In contrast, those receiving
anti-TNF therapy had the lowest prevalence. The overall hospitalization
rate, ICU admission rate, and mortality of ARD patients due to COVID-19
were 0.402(95%CI:0.330-0.476), 0.077(95%CI:0.051-0.107), and
0.073(95%CI:0.046-0.104). Using bDMARDs had lower hospitalization
rates[0.216(95%CI:0.147-0.286)], ICU admission
rates[0.010(95%CI:0.000-0.037)], and
mortality[0.039(95%CI:0.007-0.087)]. Regression analysis showed a
significant negative relationship between bDMARDs monotherapy and ICU
admission rates(regression coefficient:-0.156, 95%CI:-0.260 - -0.051,
P=0.006). Patients using csDMARDs had higher hospitalization
rates[0.607(95%CI:0.450-0.755)], ICU admission
rates[0.055(95%CI:0.037-0.075)], and
mortality[0.074(95%CI:0.041-0.114)]. Patients using GC had a higher
hospitalization rate[0.703(95%CI:0.449-0.910)], higher ICU
admission rate[0.094(95%CI:0.046-0.152)], and lower
mortality[0.070(95%CI:0.033-0.114)]. Regression analysis showed a
significant positive correlation between GC monotherapy and
hospitalization(regression coefficient:0.484, 95%CI:0.146-0.822,
P=0.006). For ARD patients, csDMARDs were associated with disease
severity in COVID-19, bDMARDs were associated with a reduced risk of
severe disease, and GC was effective in patients with severe
COVID-19-related respiratory failure.
Effect of adaptive deep brain stimulation in patient with Parkinson disease: A case report
Authors: Patel Tirath
Published: March 2023

Adaptive deep brain stimulation (aDBS) is a promising therapy for
Parkinson’s disease (PD) that has the potential to improve treatment
outcomes and reduce side effects compared to traditional, continuous
DBS. In aDBS, the stimulation parameters are adjusted in real-time based
on feedback from the patient’s brain signals or symptoms. This allows
for more precise and personalized stimulation, tailored to the patient’s
needs and fluctuating symptoms. Several studies have demonstrated the
feasibility and effectiveness of aDBS in PD patients, with improvements
in motor symptoms, quality of life, and reduction in medication usage.
Furthermore, aDBS may have the potential to reduce the incidence of
DBS-related side effects, such as speech and gait disturbances, as well
as decrease battery usage and prolong device longevity. Despite the
promising results, aDBS is still in the early stages of development and
requires further research to fully understand its mechanisms and
optimize its parameters. Challenges remain in identifying the optimal
biomarkers for aDBS, designing closed-loop systems that can effectively
integrate feedback signals and stimulation parameters, and assessing
long-term efficacy and safety. In conclusion, aDBS is a promising
approach that has the potential to revolutionize DBS therapy for PD.
Further research is needed to refine the technology, identify the
optimal biomarkers, and determine the most effective stimulation
strategies for individual patients.
Mantle Deformation Processes during the Rift-to-Drift Transition at Magma-Poor Margins
Authors: Montiel Nicholas J , Masini Emmanuel , Lavier Luc L , Muntener Othmar , Calassou Sylvain
Published: March 2023

The rift-to-drift transition at rifted margins is an area of active
investigation due to unresolved issues of the ocean-continent transition
(OCT). Deep structures that characterize modern OCTs are often difficult
to identify by seismic observations, while terrestrial exposures are
preserved in fragments separated by tectonic discontinuities. Numerical
modeling is a powerful method for contextualizing observations within
rifted margin evolution. In this article, we synthesize geological
observations from fossil ocean-continent transitions preserved in
ophiolites, a recent seismic experiment on the Ivorian Margin of West
Africa, and GeoFLAC models to characterize mantle deformation and melt
production for magma-poor margins. Across varied surface heat fluxes,
mantle potential temperatures, and extension rates our model results
show important homologies with geological observations. We propose that
the development of large shear zones in the mantle, melt infiltration,
grain size reduction, and anastomosing detachment faults control the
structure of OCTs. We also infer through changes in fault orientation
that upwelling, melt-rich asthenosphere is an important control on the
local stress environment. During the exhumation phase of rifting,
continentward-dipping shear zones couple with seaward-dipping detachment
faults to exhume the subcontinental and formerly asthenospheric mantle.
The mantle forms into core-complex-like domes of peridotite at or near
the surface. The faults that exhume these peridotite bodies are largely
anastomosing and exhibit magmatic accretion in their footwalls. A
combination of magmatic accretion and volcanic activity derived from the
shallow melt region constructs the oceanic lithosphere in the footwalls
of the out-of-sequence, continentward-dipping detachment faults in the
oceanic crust and subcontinental mantle.
Characterizations of EP elements in rings with involution
Authors: Zhou Hainan , Li Anqi , Wei Junchao
Published: March 2023

In this paper, we present a number of new characterizations of EP elements in
rings with involution. Some well-known results are extended to more general
settings. In addition, we specially investigate the EP elements by certain
equations. Proofs of relevant conclusions are also given.
Study of European style options under Itô-McKean Brownian motion with Azzalini skew-normal distribution
Authors: Hussain Sultan , Rehman Nasir , Fatima Faryal , Saleem Muhammad
Published: March 2023

In this article, we deal European style option, with arbitrary payoff which
includes both put and call options, on an asset whose price evolves as It?-McKean skew Brownian motion with Azzalini skew-normal distribution.
Initially, we investigate a condition which leads the It?-McKean skew
Brownian motion to be a martingale. Next, we price the option and show that
if the payoff function is convex then so is the price function. After this,
we show if the payoff is finite then the price function satisfies a partial
differential equation with respect to time. Further, we provide a necessary
and sufficient condition for the price function to satisfy Feymann-Kac type
equation. Next, we study Black-Scholes type equation and give expressions
for the delta hedge. Finally, we study the particular case of an European
call option in order to compare some of our results with the existing
literature. Our results can be used to investigate the optimal exercise
boundary, discrete time hedging strategies etc. of the option.
A class of weighted Delannoy numbers
Authors: Grau José , Oller-Marcén Antonio , Varona Juan
Published: March 2023

The weighted Delannoy numbers are defined by the recurrence relation fm,n =
? fm?1,n +? fm,n?1 + ? fm?1,n?1 if mn > 0, with fm,n = ?m?n if nm = 0. In
this work, we study a generalization of these numbers considering the same
recurrence relation but with fm,n = AmBn if nm = 0. More particularly, we
focus on the diagonal sequence fn,n. With some ingenuity, we are able to
make use of well-established methods by Pemantle and Wilson, and by Melczer in
order to determine its asymptotic behavior in the case A, B, ?, ?, ? ? 0. In
addition, we also study its P-recursivity with the help of symbolic
computation tools.
Efficacy and Safety of Tumour Necrosis Factor-α Antagonists for Folliculitis Decalvans: A Retrospective Case-series Pilot Study
Authors: Dupont Aurore , Eyraud Alexia , Milpied Brigitte , De Bataille Sylvie , Cassassa Eline , Darrigade Anne-Sophie , Barnetche Thomas , Doutre Marie-Sylvie , Matard Bruno , Beylot-Barry Marie , Seneschal Julien
Published: March 2023

Folliculitis decalvans is a chronic inflammatory skin disease leading to scarring alopecia. Management of this disabling disease is difficult and no treatment is currently approved. Current knowledge regarding the pathogenesis of folliculitis decalvans suggests the benefit of using anti-tumour necrosis factor-α. This pilot study aimed to evaluate the clinical efficacy of anti-tumour necrosis factor-α for management of folliculitis decalvans. A single-centre retrospective pilot study included patients with refractory folliculitis decalvans treated by tumour necrosis factor-α inhibitors. An Investigator’s Global Assessment (IGA) score was designed and validated to assess the efficacy of the therapy. Response to treatment was considered good to excellent when an IGA ≤ 2 was obtained at month 12. Eleven patients were included, with a mean time from diagnosis of folliculitis decalvans to the introduction of infliximab (n = 9) or adalimumab (n = 2) of 8.55 ± 1.26 years. Nine patients had failed on at least 2 lines of systemic therapies before starting anti-tumour necrosis factor-α. The median IGA score at baseline was 3. At the end of follow-up, 5 patients were considered responders. Overall, the safety profile of anti-tumour necrosis factor-α was good. The results suggest that the clinical benefit of anti-tumour necrosis factor-α is obtained after at least 6 months of treatment. However, further prospective studies are needed to confirm these results.
Systemic Sarcoidosis with Cutaneous Tattoo Involvement Following COVID-19 Vaccination
Authors: Albers Carolin Constanze , Metze Dieter , Steinbrink Kerstin , Böhm Markus
Published: March 2023

Abstract is missing (Short communication)
IDENTIFIKASI POTENSI LAHAN DAN FUNGSI KAWASAN UNTUK PENGEMBANGAN KAWASAN BUDIDAYA PERTANIAN LAHAN KERING DI DAERAH ALIRAN SUNGAI BULELENG
Authors: Budiarta I Gede
Published: March 2023

Penelitian ini bertujuan untuk menentukan 1) tingkat kesesuaian penggunaan lahan pada wilayah DAS di Buleleng; 2) zona fungsi kawasan pada DAS Buleleng; Metode yang digunakan untuk mengevaluasi kesesuaian penggunaan lahan dan indeks penutupan lahan adalah Peraturan Menteri Kehutanan Republik Indonesia Nomor : P. 32/MENHUT-II/2009. Sementara metode penentuan fungsi kawasan menggunakan SK Menteri Pertanian No. 837/Kpts/Um/11/1980 dan No. : 683/Kpts/Um/8/1981. Kriteria tingkat kesesuaian penggunaan lahan terdiri atas tiga kategori, yaitu baik, (kesesuaian >75%), sedang (40-75%), dan rendah ( <40%). Kriteria indeks penutupan lahan tergolong tinggi apabila tutupan vegetasi mencapai > 75%, sedang jika tutupannya antara 35-75%, dan rendah jika < 35%. Pemetaan fenomena geospasial terkait dengan persebaran kesesuaian penggunaan lahan dan indeks penutupan lahan menggunakan perangkat lunak ER Mapper, MapInfo Professional, dan ArcView GIS. Hasil penelitian menunjukkan bahwa kesesuaian penggunaan lahan DAS Buleleng pada masing-masing unit lahan yaitu: unit lahan dengan kriteria rendah (10 %), unit lahan 2 dengan kriteria rendah (11 %), kriteria sedang pada unit lahan 3 (62 %), kriteria sedang pada unit lahan 4 (69 %), unit lahan 5 dengan kriteria tinggi (77 %), unit lahan 6 dengan kriteria tinggi (85 %), dan unit lahan 7 dengan kriteria tinggi (93 %). Terdapat empat zona fungsi kawasan pada DAS Buleleng, yaitu 1) kawasan budidaya tanaman semusim (unit lahan 1 dan 2); kawasan budidaya tanaman tahunan (unit lahan 3); kawasan penyangga (unit lahan 4 dan 5); serta kawasan lindung (unit lahan 6 dan 7).
PEMANFAATAN METODE FOTOGRAMETRI UNTUK PEMETAAN SKALA 1 : 1000 (STUDI KASUS : UNIVERSITAS PENDIDIKAN INDONESIA)
Authors: Rachmanto Dendi Haris , Ihsan Muhammad
Published: March 2023

Fotogrametri merupakan seni, ilmu dan teknologi dalam memperoleh informasi yang terpercaya mengenai obyek-obyek dan lingkungan fisik, melalui proses perekaman, pengukuran dan penafsiran citra fotografik, yang dimana aspek-aspek geometrik dari foto udara seperti sudut, jarak, koordinat, dan sebagainya merupakan faktor utama, cepatnya perkembangan dari teknologi dalam bidang survey dan pemetaan yaitu Wahana Unmanned Aerial Vehicle membuat penulis melakukan sebuah penelitian pada lingkungan kampus dengan tujuan menghasilkan informasi spasial kampus UPI dari hasil orthophoto dengan skala besar yang sesuai dengan Peraturan Badan Informasi Geospasial,disisi lain Badan Informasi Geospasial selaku lembaga yang mengurusi perumusan, penyusunan rencana, dan pelaksanaan pengawasan fungsional pada informasi spasial membuat kebijakan tentang standarisasi dari pemetaan fotogrametri.kebijakan tersebut menitik beratkan pada koreksi geometri foto udara dilakukan dengan cara membandingkan koordinat foto udara dengan koordinat hasil pengolahan data GPS. Pengujian ketelitian posisi mengacu pada perbedaan koordinat (X, Y) antara titik uji pada gambar dengan lokasi sesungguhnya. Hasil akhir dari kegiatan survey foto udara yaitu berada pada tahap uji akurasi yaitu Root Mean Square Error (RMSE) digunakan untuk menggambarkan akurasi meliputi kesalahan random dan sistematik. dengan nilai yang didapat pada saat pengolahan 0.190029m selanjutnya nya menghitung nilai dari Circular Error 90% (CE90) yaitu ukuran ketelitian geometrik horizontal yang didefinisikan sebagai radius lingkaran yang menunjukkan bahwa 90% kesalahan atau perbedaan posisi horizontal objek di peta dengan posisi sebenarnya. Maka hasil akhir dari uji akurasi ini bahwa CE90 = 0.288368 berada pada skla 1 :1000 Kelas 2 ketelitian peta dasar
PEMETAAN SEBARAN TINGKAT POTENSI OBJEK WISATA YANG TERDAPAT DI KECAMATAN NUSA PENIDA
Authors: Wisnawa I Gede Yudi , Jayantara I Gst Ngr Yoga , Gunawan I Kadek
Published: March 2023

Kecamatan Nusa Penida merupakan wilayah di Bali yang memiliki karakteristik unik yang dilihat dari bentuk wilayah sumber daya alam hayati maupun non hayati selain eksistensi kebudayaan yang ada. Hal ini menjadikan daya tarik tersendiri bagi masyarakat dari berbagai kalangan untuk mengeksplorasi wilayah Nusa Penida. Perkembangan pariwisata di Kecamatan Nusa Penida  belum diimbangi dengan penataan dan pengelolaan dari Pemerintah setempat baik dari sarana maupun prasarana yang belum memadai dan Pentingnya pendataan terkait tingkat potensi objek wisata yang tersebar di Kecamatan Nusa Penida sebagai pedoman untuk pengelolaan dan strategi pengembangan tingkat potensi objek wisata di Kecamatan Nusa Penida. Penelitian ini menggunakan metode penelitian survei dengan menggunakan teknik dokumentasi dan observasi dalam pengumpulan data. Objek dalam penelitian ini berupa sebaran tingkat potensi objek wisata. Teknik analisis dalam penelitian ini dilakukan dengan cara analisis deskriptif dan analisis deskriptif kuantitatif yang dikorelasikan dengan menggunakan teknik skoring. Teknik ini digunakan untuk mengetahui perolehan skor tertinggi dan skor terendah yang nantinya akan dianalisis dan diklasifikasikan ke dalam kategori skor. Hasil penelitian menunjukkan bahwa Terdapat 25 sebaran objek wisata, 6 diantaranya merupakan objek wisata yang memiliki tingkat objek wisata sangat berpotensi, 13 titik sebaran tingkat potensi objek wisata yang berpotensi dan 6 titik tingkat potensi objek wisata wisata yang tidak berpotensi. Selain itu masih terdapat banyak objek wisata yang perlu dikembangkan oleh masyarakat dan pemerintah setempat untuk meningkatkan objek daya tarik wisata yang ada di Kecamatan Nusa Penida. Desa Sakti memiliki lokasi objek wisata paling banyak sedangkan Desa Klumpu dan Desa Batumadeg hanya memiliki 1 lokasi objek wisata. Selain itu terdapat beberapa desa yang masih belum memiliki objek wisata yaitu Desa Ped, Kutampi Kaler, Kutampi, Batununggul, Suana dan Desa Sekartaji.