bluuebunny/crossref_metadata_2025 huggingface dataset:
Versatile Applications of Cyanoacetic Acid in Organic Chemistry: Active Methylene Compound for the Knoevenagel Condensation and Organocatalyst for the Biginelli Reaction
Authors: Zanin Lucas , Jimenez David , Baia Gabriel , Marinho Victor , de Araujo Inana , Ramos Ryan , Soto Raimundo , Ferreira Irlon , Santiago Pedro , Ellena Javier , Porto André
Published: January 2024

The application of cyanoacetic acid as a catalyst for the Biginelli reaction and as an active methylene compound for the Knoevenagel condensation reaction was evaluated. Using cyanoacetic acid as a Bronsted acid catalyst, after a synthetic optimization process, it was possible to synthesize eight dihydropyrimidinones with good yields (80-99%) using ethanol as solvent. It is the first time, to our knowledge, that the use of cyanoacetic acid is reported in the synthesis of this class of compounds, which have a wide bioactive potential. Also, cyanoacetic acid was used as a reagent in the Knoevenagel condensation, through which polyfunctionalized olefins were obtained and can be used as building blocks for structurally complex molecules. By using KOH as catalyst, eleven Knoevenagel adducts were synthesized with good yields (65-97%), under microwave irradiation as heating source, in water. Moreover, Knoevenagel adducts containing halogenated substituents (F, Cl) showed potential larvicidal activity with lethal concentrations (LC50) of 19.63, 33.84 µg mL-1 and LC90 of 27.46 and 48.16 µg mL-1. This study showed the versatility of cyanoacetic acid as a catalyst for the synthesis of dihydropirimidinones, aldol compounds and presented the first study showing their larvicidal activity against Aedes aegypti.
Smart Films Produced by Electrospinning of Poly(butylene-adipate-co‑terephthalate)/poly-(ε-caprolactone) for Controlled Delivery of Ibuprofen
Authors: Hardt Janice , Fraga Gabriel , Medeiros Alessandra , Rossin Ariane , Caetano Josiane , Leite Matheus , da Fonseca Bruno , Vilsinski Bruno , Dragunski Douglas
Published: January 2024

Wound dressing devices composed of microfibers of poly(butylene-adipate-co-terephthalate) and poly-(ε-caprolactone) incorporated with ibuprofen were obtained by electrospinning technique. The effect of ibuprofen concentration (0, 10, and 20% m m-1) on morphology, spectroscopic, and thermal characterization was evaluated. The fibers containing ibuprofen presented beads and revealed no uniformity. The spectroscopic analysis showed signals that reveal the ibuprofen incorporation on fibers. At the same time, X-ray diffraction spectroscopy indicated a difference in the fiber crystallinity depending on drug concentration, where a lower crystallinity was verified by the film containing a greater concentration incorporated. Rheological measurements revealed that films were more plastic in greater ibuprofen incorporation. Contact angle characterization revealed that ibuprofen solubilization on composite surfaces increased the film wettability. Finally, the fibers promoted the controlled release of ibuprofen, promoting morphological changes in polymeric matrices. The material developed can be used in future biomedical applications.
Quality of Life for Disabled Children: Parenting Patterns, Community Social Attitudes, and Social Service Role
Authors: Arini Yusti , Sulistyarini Ika
Published: January 2024

Phenomena about children with disabilities in Salatiga still show that there are some problems related to the quality aspect of their lives. This study aims to examine parenting patterns, social attitudes, and role of the Social Service in improving the quality of life for children with disabilities. This research is a mixed-methods research using congruent design. The research subjects consisted of 66 parents of children with disabilities selected using the purposive sampling technique and 87 residents of Salatiga City selected using cluster sampling technique. Data was collected through interviews, surveys, and documentation, then analyzed quantitatively and qualitatively. The results show that parents with disabled children have a democratic parenting style, the social attitude of Salatiga City residents is good, full of empathy, and full of support; however, the Social Service Office does not yet have programs directly intended for children with disabilities in Salatiga. Research novelty is reflected by the variables and research method, which are different from previous studies.
Pregnancy Risks of Young Mothers in Medical Discourse and Cultural Settings
Authors: Rani Anisa Puspa , Nugroho Heru , Asriani Desintha Dwi
Published: January 2024

East Lombok Regency, despite implementing pregnancy health programs, grapples with a persistently high pregnancy risk. This study investigates the disparity between medical and Sasak cultural perspectives on young mothers’ pregnancy risks. Qualitative case study research reveals a conflict between community sociocultural narratives and medical viewpoints. Cultural norms normalize medical narratives, shaping pre-marital reproductive arrangements, body perceptions, and idealized pregnancy concepts. Young mothers, influenced by cultural values, accept pregnancy as a collective social process within the family. The study emphasizes the impact of cultural determinism on shaping perceptions and preferences for young mothers’ pregnancy health, highlighting the need for an integrated approach that bridges medical and cultural perspectives to address and mitigate pregnancy risks effectively.
Contestation between Fiqh and Culture in Indonesia: The Maqāṣid al-Sharī’ah Paradigm in Dangers of Forced Marriage against Women
Authors: Agustina Arifah Millati
Published: January 2024

This article addresses the contentious issues between Islamic Jurisprudence (fiqh) and cultural practices related to forced marriage. Motivated by the widespread prevalence of forced marriage in society, often perpetuated with religious arguments, the research aims to provide insights into the meaning of the term “ijbar” in fiqh discourse. While fiqh interprets “ijbar” as a custodian’s right to coerce their daughter, the article highlights the specific term “ikrah” for coercion in Islamic law. Utilizing a qualitative method, the study involves document analysis through an in-depth examination of fiqh literature. Data sources include classical and contemporary jurisprudence literature, information on forced marriages in Indonesia, and religious fatwas from the Indonesian Women’s Ulama Congress (KUPI). The article argues that forced marriage contradicts the maqāṣid al-sharī'ah, evidenced by spiritual and religious decline, domestic violence, restricted access to education, adverse reproductive effects, and limited economic resources.
The Jacobi - Poisson Method of Building First Integrals for System of Ordinary Differential Equations
Authors:   Yanka Kupala State University of Grodno, Pranevich Andrei
Published: January 2024

In this paper, the Jacobi-Poisson method of building first integrals by known integral manifolds for Hamiltonian differential systems is developed. The existence theorem of first integrals in the form of Poisson brackets from known integral manifolds for Hamiltonian systems is proved. The statement of finding additional first integrals by known first integrals and integral manifolds for Hamiltonian systems is given. In the case of polynomial Hamiltonian systems, we use the concept of partial integrals and concretize ours results. The Jacobi - Poisson method of construction first integrals in the form of Poisson brackets from known integral characteristics (integral manifolds, partial integrals, and first integrals) for general ordinary differential systems is proposed. Statements of finding first integrals for an ordinary differential system by integral characteristics of the auxiliary Hamiltonian system are obtained. The generalized Poisson theorem of construction first integrals is indicated. And, the question of the existence of partial integrals and first integrals in the form of Poisson brackets for ordinary polynomial differential systems is investigated. The results obtained in this paper can be used in the analytical theory of differential equations and in the analytical mechanics.
ORTEGA Y GASSET AND THE QUESTION OF THE BODY
Authors:   Spanish Council for Scientific Research (CSIC), SERRANO DE HARO AGUSTÍN
Published: January 2024

My essay is devoted to the very early and attractive understanding of the lived body in Ortega y Gasset’s thought. I focus especially on the text “Vitality, Soul, Spirit” of 1925, which can be considered a proto-phenomenological approach to the issue of embodiment. Ortega identifies “vitality” with “the intrabody” and makes the latter the founding dimension of subjectivity, at the basis of the affective sphere (“soul”) and at the basis of the intellectual and volitional sphere (“spirit”). In a manner very close to Husserl’s unpublished manuscripts, he also shows how the body is the only reality of which there is simultaneously external perception, as if it were just another thing in the world that everyone else can see, and internal perception, which only the self can have and feel. The study also points out, however, the two major difficulties that I detect in Ortega’s precocious attempt. A first doubt concerns the too sharp stratification of vitality, soul and spirit, as can be seen in the analysis of the experiences of pain and of mobility. A second doubt concerns the ontological hesitations surrounding Ortega’s position, which is torn between a coherent phenomenological perspective and a vitalist position in which my body is only an emanation of the lifestream of the universe.
ARE THERE TRACES OF PHENOMENOLOGY IN ZUBIRI’S NATURALEZA, HISTORIA, DIOS?
Authors:   Royal Academy of Moral and Political Sciences of Spain, GARCÍA-BARÓ LÓPEZ MIGUEL
Published: January 2024

This article deals with the reception of phenomenology by Xavier Zubiri, one of the most important figures of 20th century Spanish philosophy. During his lifetime Zubiri published few books, but he left an immense legacy of courses and manuscripts. Among the most important published works is the book Naturaleza, Historia, Dios. Zubiri explains there his critical reception of phenomenology: he subscribes to it, insofar as it is a philosophy of things themselves. But this evaluation of phenomenology is at the same time a farewell to her. Zubiri’s philosophical project consists in giving a reason not for things as objects of consciousness, but rather for their entitary or real structure. Thus, his purpose is to establish a logic of reality or new metaphysics that is at the same time different from the old ontology and whose sources of inspiration are Heidegger and Aristotle. To the author of this essay seems also highly probable that Alfred N. Whitehead influenced decisively certain prominent features of Zubiri’s ontological program. Husserl’s treatment of the theory of wholes and parts in Logical Investigations III pertains also to the intellectual basis of Zubiri. The article raises the question of the traces of phenomenology that are still present in Naturaleza, Historia, Dios, and critically assesses their importance for phenomenological philosophy today. The article shows above all how Zubiri’s perspective vindicates phenomenologically the traditional concept of Man and his experience of religious connection (religatio) with a transcendent Grund. As a consequence, the traditional notions of spiritual reality, eros and agape are given a new meaning.
HEIDEGGER’S NOTION OF POETRY AS AN INDICATIVE LETTING-SEE OF THE WAYS OF BEING
Authors:   University of the Pacific, IVANOFF-SABOGAL CHRISTIAN
Published: January 2024

The goal of this article is to understand the concept of poetry in the broad context of Heidegger’s “early” thought, around 1919 and 1930. To that end, we seek to disclose a relation that in Heidegger remains implicit and in the secondary literature absent. This is the relation between poetry and the ways of Being (existence, ready-to-hand, present-at-hand, etc.). Since Heidegger did not explicitly thematize poetry in this broad context, the setup of this article consists of three main steps, in which we make explicit the implicit ontological notion of Heidegger about poetry and, we shall argue, the ontological status of the poeticized. First, we distinguish between the theoretical and the pre-theoretical dimensions of existence, which enable us to explain that for Heidegger poetry is a pre-theoretical letting-see of the various entities that we encounter in the immediate everyday life that is mostly overlooked because of their “self-evident” and “obvious” presence. In this first step we argue that for Heidegger poetry is partially an explicit ontic letting-see. Second, we address the ways of Being in order to secure the systematic horizon for our interpretation regarding the relationship between the ways of Being and poetry. Third, we discuss that an indicative and non-conceptual letting-see of pre-theoretical ways of Being takes place in poetry through the respective poetized entity. In the second and third steps, we exhibit that according to Heidegger poetry results ultimately in an implicit ontological letting-see of the ways of Being.
Computer Tomography (CT)-Based Study to Investigate Feasibility and
Efficacy of Thoracoscopic Surgery in the Treatment of Penetrating Chest Wall
Tuberculosis
Authors: Xing Fuchen , Zhang Xia , Ji Saiguang , Zeng Yi , Zhou Hai , Xu Jian , Wang Chenyan , Liu Hong
Published: January 2024

Background::

Chest wall tuberculosis may develop if tuberculous (TB) lesions spread through the chest wall and invade the thoracic cavity. The presence of a
mass on the patient's chest wall may be the first indication of TB, and a chest CT scan can help diagnose external penetrating chest wall TB, the
incursion of tuberculosis from the lungs into the chest wall.

Objective::

This study examines the safety and efficacy of thoracoscopic-assisted surgery for the treatment of penetrating chest wall tuberculosis as a means of
exploring novel concepts of minimally invasive surgery.

Methods::

Our hospital conducted a retrospective study of 25 patients with penetrating chest wall TB who underwent thoracoscopic surgery between January
2020 and June 2021. General demographics, CT scan data linked to surgery, and postoperative patient outcomes were compared between the two
groups. The data was also evaluated to determine the range of operation time and the volume of bleeding from different foci in the thoracic cavity.

Results::

All procedures went well after patients took conventional antituberculosis medication for at least two weeks prior to surgery. CT scans showed that
thoracoscopic surgery needed a smaller incision than traditional chest wall TB surgery, with no discernible increase in surgical time. Postoperative
tube use, length of hospital stay, and blood loss were all significantly lower than they would have been with conventional surgery. In addition,
thoracoscopy was associated with a significantly reduced rate of subsequent treatment. Fibrous plate development and calcification caused the
longest operation times in the thoracoscopic surgery group, whereas multiple pleural tuberculomas generated the most hemorrhage. Thoracoscopic
surgery usually reveals tuberculous foci hiding in the thoracic cavity.

Conclusion::

Thethoracic surgery can eliminate the TB focus in the chest wall and intrathoracic while treating penetrating chest wall tuberculosis. The CT scan
is a crucial part of the diagnostic process for these patients. Minor surgical trauma, low complication and recurrence rates, and good results. There
is a greater distinction between the two surgical approaches for patients with penetrating chest wall TB as opposed to those with basic chest wall
tuberculosis.
PENGEMBANGKAN WISER BERBANTUAN MEDIA REKAM TANGKAP LAYAR UNTUK MENINGKATKAN KETERAMPILAN KOMUNIKASI
Authors:   Sekolah Menengah Pertama Islam Sabilillah Malang, Kusmiati Kusmiati
Published: January 2024

This article aims to describe the importance of improving students' communication skills by developing WISER assisted with screen capture media on Smart Digital Learning (SDL). Communication skill is a skill that needed in today's era of globalization. Good communication skills can lead students to reach their future. However, in reality, there are still many obstacles to this skill. So, a strategy, as well as media, is needed to support its improvement. This study uses classroom action research using two cycles. The research subjects were 29 students of VII graders. The results showed that the students' communication skills in the first cycle with the percentage of completeness of 89.66% increased to 96.55% in the second cycle. Then, the score for students' communication skills from the category good improved to the very good. The conclusion is that the students' communication skills improve by developing WISER (Wondering habits, Investigating skills, Synthezing skills, Expressing skills , and Reflecting habits) assisted by screen capture media of procedure text in learning to present procedure texts for VII grade of SMP Islam Sabilillah Malang
Studi Penjadwalan Pelaksanaan Pembangunan PLTMH Anggi Kabupaten Arfak Provinsi Papua Barat
Authors: Adityawitari Fadhilah Filzah , Pitojo Tri Juwono  , Andre Primantyo H
Published: January 2024

Energi listrik memegang peranan yang sangat penting dalam upaya meningkatkan kualitas hidup dan pertumbuhan ekonomi di Indonesia. Keterbatasan pasokan energi listrik menjadi salah satu penghambat pertumbuhan dan perkembangan masyarakat, khusunya di Kabupaten Arfak Provinsi Papua Barat. Secara umum daerah pegunungan mempunyai potensi hidrolik yang cukup besar. Pembangkit listrik tenaga mikrohidro merupakan pembangkit listrik yang terbarukan, efisien, praktis dan ramah lingkungan. Oleh karena itu, tujuan dari penelitian ini adalah untuk mengoptimalkan waktu, sumber daya, dan alat berat yang digunakan dengan biaya proyek yang paling efisien dengan menggunakan aplikasi Microsoft Project. Durasi normal Proyek PLTMH Anggi di Kabupaten Arfak Provinsi Papua Barat adalah 180 hari kerja dengan nilai kontrak sebesar Rp. 10.803.303.233. Dalam studi ini dilakukan alternatif percepatan, yaitu penambahan jam kerja dengan bantuan program Microsoft Project dengan penerapan levelling, terjadi penurunan rencana anggaran biaya sebesar 4,5%. Selanjutnya, penjadwalan menggunakan alternatif penambahan jam kerja dengan bantuan program Microsoft Project. Hasil yang diperoleh adalah ketika menggunakan alternatif penambahan jam kerja, terjadi penurunan biaya sebesar 4,3% dan durasi proyek lebih cepat 14 hari dari perencanaan awal.
Impact of Translation on Biomedical Information Extraction: Experiment on Real-Life Clinical Notes
Authors: Gérardin Christel , Xiong Yuhan , Wajsbürt Perceval , Carrat Fabrice , Tannier Xavier
Published: January 2024

Background

Biomedical natural language processing tasks are best performed with English models, and translation tools have undergone major improvements. On the other hand, building annotated biomedical data sets remains a challenge.

Objective

The aim of our study is to determine whether the use of English tools to extract and normalize French medical concepts based on translations provides comparable performance to that of French models trained on a set of annotated French clinical notes.

Methods

We compared 2 methods: 1 involving French-language models and 1 involving English-language models. For the native French method, the named entity recognition and normalization steps were performed separately. For the translated English method, after the first translation step, we compared a 2-step method and a terminology-oriented method that performs extraction and normalization at the same time. We used French, English, and bilingual annotated data sets to evaluate all stages (named entity recognition, normalization, and translation) of our algorithms.

Results

The native French method outperformed the translated English method, with an overall F1-score of 0.51 (95% CI 0.47-0.55), compared with 0.39 (95% CI 0.34-0.44) and 0.38 (95% CI 0.36-0.40) for the 2 English methods tested.

Conclusions

Despite recent improvements in translation models, there is a significant difference in performance between the 2 approaches in favor of the native French method, which is more effective on French medical texts, even with few annotated documents.
The Sukaribit Smartphone App for Better Self-Management of Type 2 Diabetes: Randomized Controlled Feasibility Study (Preprint)
Authors: Josefsson Cecilia , Liljeroos Thea , Hellgren Margareta , Pöder Ulrika , Hedström Mariann , Olsson Erik M G
Published: January 2024

BACKGROUND

A new app, Sukaribit, was designed to enable contact between the caregiver and the patient with the intent to improve self-care and glycemic control (hemoglobin A1c [HbA1c]).

OBJECTIVE

This study investigated the feasibility of the study methodology and the intervention in preparation for a larger effectiveness study.

METHODS

Adults with type 2 diabetes were recruited in this randomized controlled feasibility study with a mixed methods design. The intervention group (n=28) tried Sukaribit for 2 months. They were encouraged to report blood glucose levels and medications, and they received feedback from a physician. The control group (n=31) received standard care. Both groups were evaluated with pre and postmeasurements of glycemic control (HbA1c), diabetes distress, physical activity, and self-care. Feasibility was evaluated against 5 progression criteria regarding recruitment, study methods, and active participation.

RESULTS

Of the 5 progression criteria, only 2 were met or partially met. The recruitment process exceeded expectations, and data collection worked well for self-reported data but not for HbA1c measured with a home testing kit. The participants were less active than anticipated, and the effect sizes were small. Only the number of blood glucose tests per day was positively affected by the intervention, with 0.6 more tests per day in the intervention group.

CONCLUSIONS

Recruitment of participants to a future fully powered study may work with minor adjustments. The collection of HbA1c using home testing constituted a major problem, and an alternative strategy is warranted. Finally, the app was not used as intended. In order to proceed with a larger study, the app and study procedures need improvement.
Smoking Behavior Change and the Risk of Heart Failure in Patients With Type 2 Diabetes: Nationwide Retrospective Cohort Study (Preprint)
Authors: Yoo Jung Eun , Jeong Su-Min , Lee Kyu Na , Lee Heesun , Yoon Ji Won , Han Kyungdo , Shin Dong Wook
Published: January 2024

BACKGROUND

Heart failure (HF) is one of the most common initial manifestations of cardiovascular disease in patients with type 2 diabetes. Although smoking is an independent risk factor for HF, there is a lack of data for the incidence of HF according to changes in smoking behaviors in patients with type 2 diabetes.

OBJECTIVE

We aimed to examine the association between interval changes in smoking behavior and the risk of HF among patients with type 2 diabetes.

METHODS

We conducted a retrospective cohort study using the National Health Insurance Service database. We identified 365,352 current smokers with type 2 diabetes who had 2 consecutive health screenings (2009-2012) and followed them until December 31, 2018, for the incident HF. Based on smoking behavior changes between 2 consecutive health screenings, participants were categorized into quitter, reducer I (≥50% reduction) and II (<50% reduction), sustainer (reference group), and increaser groups.

RESULTS

During a median follow-up of 5.1 (IQR 4.0-6.1) years, there were 13,879 HF cases (7.8 per 1000 person-years). Compared to sustainers, smoking cessation was associated with lower risks of HF (adjusted hazard ratio [aHR] 0.90, 95% CI0.86-0.95), whereas increasers showed higher risks of HF than sustainers; heavy smokers who increased their level of smoking had a higher risk of HF (aHR 1.13, 95% CI 1.04-1.24). In the case of reducers, the risk of HF was not reduced but rather increased slightly (reducer I: aHR 1.14, 95% CI 1.08-1.21; reducer II: aHR 1.03, 95% CI 0.98-1.09). Consistent results were noted for subgroup analyses including type 2 diabetes severity, age, and sex.

CONCLUSIONS

Smoking cessation was associated with a lower risk of HF among patients with type 2 diabetes, while increasing smoking amount was associated with a higher risk for HF than in those sustaining their smoking amount. There was no benefit from reduction in smoking amount.
Remote Inclusion of Vulnerable Users in mHealth Intervention Design: Retrospective Case Analysis (Preprint)
Authors: Straand Ingjerd J , Baxter Kimberley A , Følstad Asbjørn
Published: January 2024

BACKGROUND

Mobile health (mHealth) interventions that promote healthy behaviors or mindsets are a promising avenue to reach vulnerable or at-risk groups. In designing such mHealth interventions, authentic representation of intended participants is essential. The COVID-19 pandemic served as a catalyst for innovation in remote user-centered research methods. The capability of such research methods to effectively engage with vulnerable participants requires inquiry into practice to determine the suitability and appropriateness of these methods.

OBJECTIVE

In this study, we aimed to explore opportunities and considerations that emerged from involving vulnerable user groups remotely when designing mHealth interventions. Implications and recommendations are presented for researchers and practitioners conducting remote user-centered research with vulnerable populations.

METHODS

Remote user-centered research practices from 2 projects involving vulnerable populations in Norway and Australia were examined retrospectively using visual mapping and a reflection-on-action approach. The projects engaged low-income and unemployed groups during the COVID-19 pandemic in user-based evaluation and testing of interactive, web-based mHealth interventions.

RESULTS

Opportunities and considerations were identified as (1) reduced barriers to research inclusion; (2) digital literacy transition; (3) contextualized insights: a window into people’s lives; (4) seamless enactment of roles; and (5) increased flexibility for researchers and participants.

CONCLUSIONS

Our findings support the capability and suitability of remote user methods to engage with users from vulnerable groups. Remote methods facilitate recruitment, ease the burden of research participation, level out power imbalances, and provide a rich and relevant environment for user-centered evaluation of mHealth interventions. There is a potential for a much more agile research practice. Future research should consider the privacy impacts of increased access to participants’ environment via webcams and screen share and how technology mediates participants’ action in terms of privacy. The development of support procedures and tools for remote testing of mHealth apps with user participants will be crucial to capitalize on efficiency gains and better protect participants’ privacy.
Leveraging Feedback From Families of Children With Autism to Create Digital Support for Service Navigation: Descriptive Study (Preprint)
Authors: Burke Meghan , Li Chak , Cheung Waifong Catherine , Terol Adriana Kaori , Johnston Amanda , Schueller Stephen M
Published: January 2024

BACKGROUND

It is difficult for families to navigate and access services for their children with autism. Barriers to service access are compounded among families from low-resourced backgrounds.

OBJECTIVE

The purpose of our study was to explore the development of an app to facilitate access to services among families of children with autism from low-resourced backgrounds. Our specific aims were to explore feedback from an advisory board about the app and to explore feedback from navigators about the app.

METHODS

Via a multistage codevelopment process, we elicited feedback from 5 key parties: the research team, a community organization, the app development team, the advisory board, and family navigators. Collectively, 36 individuals provided feedback about the development of the app via individual interviews, focus groups, observations, and surveys. The key features of the app included a dashboard showing the service needs of the family and related resources, a messaging feature between the family, the navigator, and the supervisor, and a fidelity checklist and evaluation feature.

RESULTS

The advisory board provided feedback about the app to increase its user-friendliness, include the ability to develop an action plan, improve the identification of needed services, and add information about service providers. Navigators suggested that the app should connect navigators to one another, have a clearer purpose for the notes section, and reflect an easier log-in process. Navigators also wanted training to role-play using the app. After participating in a role play using the app, navigators reported significantly more satisfaction with the app and greater usefulness (P<.001).

CONCLUSIONS

Our work sheds light on the importance of eliciting feedback from end users, especially users who are often overlooked by the research community and app developers. Further, it is important to elicit feedback in multiple ways to improve the app.
Kemampuan Menulis Makalah Ilmiah pada Mata Kuliah Psikolinguistik Mahasiswa Prodi Pendidikan Bahasa dan Sastra Indonesia (PBSI) FKIP Universitas PGRI Yogyakarta
Authors: Ari Wulandari  , Susetyo  , Rika Novita Kusumaningrum
Published: January 2024

The objectives of this study are to determine the ability of students Pendidikan Bahasa dan Sastra Indonesia (PBSI), FKIP, Universitas PGRI Yogyakarta (UPY) in writing scientific papers; and to find out the difficulties of students in writing scientific papers. The research method used is descriptive qualitative. The population in this study were PBSI students who were conducted in the odd semester of the 2021/2022 academic year. The sample is 31 students of class G-1 who take Psycholinguistics courses. Data in the form of scientific papers were collected in the middle of the semester of Psycholinguistics lectures. The scientific paper was analyzed using research instruments. The writing ability assessed includes five aspects, namely (1) ideas, (2) organization, (3) grammar, (4) diction, and (5) spelling. Based on the assessment, each is categorized into five, namely (1) very good with a score range of 86-100, (2) good with a score range of 68-85, (3) sufficient with a score range of 48-67, (4) less with range of values from 32 to 47, and (5) very less with a range of values <32. The results of this study stated that 31 students or 100% got an average score of 78.15 with the highest score of 83 and the lowest score of 72. This category of scores was included in good. Their abilities in expressing ideas, organization of essays, and choosing diction are good. Their shortcomings are average in terms of grammar and spelling.
Pengaruh Citra Tubuh terhadap Budaya Konsumsi pada Perempuan
Authors: Nafi Ibdiyana Musyarrifani
Published: January 2024

Women view their bodies more negatively than men and this affects their body image. Body image is a person's evaluation of his physical appearance, other people's perceptions of his body, and how his body is adapted to these perceptions. This paper will focus on discussing the arguments about how women's body image affects their consumption culture. The research method used is literature study of secondary data from book sources, online journal articles, and data published on the internet. It was found that the construction of the ideal body in society was shaped by the capitalist popular culture industry and supported by the mass media. This construction creates a standardization of the definition of ideal beauty. Not only that, the patriarchal culture that places women as symbols of beauty that fulfills aesthetic functions in the household also influences their consumption culture. In addition to being the market object of capitalism's products, women are also the main consumers of products that are believed to help increase satisfaction with their body image, such as beauty, fitness, health, and fashion products.
Arsitektur Indis dan Perubahan Sejarah Kota Magelang 1906-1942
Authors: Adyt Alkautsar  , La Ode Rabani
Published: January 2024

This study discusses the architecture of Indische buildings at Magelang Town in 1906-1942. This study uses historical research methods consisting of heuristics, source verification, data interpretation and historiography. The entry and development of Indische architecture in Magelang Town coincided with the increasingly intensive colonial government in exploiting natural resources in order to increase commodity exports. This building with Indische architecture in Magelang Town developed from 1906 to 1942 along with the fulfillment of the facilities and needs of the Dutch people who were intensively running the bureaucracy in Magelang Town. The facilities and needs referred to are infrastructure, especially housing, offices, and defense as illustrated in residential buildings, schools, lodging, hospitals, and other public facilities. In 1942, Indische architecture no longer developed in line with the end of Dutch rule in the Dutch East Indies. However, some of the Indische buildings in Magelang Town are still maintained by the community.
Praktik Peliyanan dan Pendisiplinan Tubuh Lewat Bahasa Kekerasan di Percakapan Twitter
Authors: Zul’azmi Helmi Naufal
Published: January 2024

This article aimed to identify how violent languages are operated for othering and disciplining the body as an exercise of power over the LGBTIQ groups in Indonesia. The analyzed violent language was taken from a conversation on Twitter that responds to Deddy Corbuzier’s podcast video with the title “TUTORIAL JADI G4Y DI INDO!!= PINDAH KE JERMAN (tonton sblm ngamuk) RAGIL AND FRED”. The issues of violence in language have been arising when the words used by Twitter accounts @cholilnafis, @anasabuabdillah, @mas_po_sanusi, @ridwan2474, @djoesa, @defrizonz, and @samsularifin000 are seen in a particular way in the context of their response to Deddy’s podcast video. This article shows that there is a process of othering and disciplining the body through the choices of words that contain elements of violence. Violent languages are operated to alienate others, as in the concept of “blaming others”. From Lozano and Laurent’s perspective, “blaming others” is accusing minorities under social inappropriateness instead of seeing their own fault. Meanwhile, the process of disciplining the body moves through violent languages that are associated with interpretation of Islamic discourse.
Motivasi, Persepsi, dan Perilaku Pasca Konsumsi Wisatawan Domestik Terhadap Kuliner Sate Klatak di Imogiri Timur Yogyakarta
Authors: Dewi Juwita Sari Rizky Millenia , Fonsen Muhammad Jhony , Aprilia Annisa Dwi , Syahri Aqila Ramiza , H Shafandra Cahya L , Zuhair Yasin Adib , Wachyuni Suci Sandi
Published: January 2024

Klatak satay is an iconic food originating from the Bantul Regency of Yogyakarta. Sate klatak was named the Intangible Cultural Heritage of Indonesia in 2019 by the Ministry of Education and Culture. As an Intangible Cultural Heritage, satay klatak needs to be preserved so that the regeneration process continues and its existence remains sustainable. Tourists coming to eat Sate Klatak have various motivations. The purpose of this study is to review the motivation, perception, post-consumption behaviour of domestic tourists Sate Klatak East Imogiri, Yogyakarta. This research uses a quantitative approach with a survey method. The data collection technique is by distributing online questionnaires via WhatsApp and Instagram. The results showed that the biggest motivation for tourists to consume satay klatak Imogiri was recommendations from friends and relatives. Furthermore, Sate Klatak East Imogiri is incredibly well-received because of its popularity, taste, and appearance. Tourists also show satisfaction in post-consumption behavior, namely, returning and recommending it to relatives. The theoretical implication of this study is that these three variables can be used as indicators of local culinary evaluation. Meanwhile, as a practical implication, the research results can be used as suggestions for local culinary development in destinations, especially Sate Klatak East Imogiri
Kompetisi dan Posisi Tubuh Perempuan dalam Iklan Rokok: Analisis Wacana Kritis Pada Novel “Gadis Kretek” Karya Ratih Kumala
Authors: Indriani Laillia Dhiah
Published: January 2024

Using women's bodies in product marketing advertisements is nothing new. The female body is deliberately presented as a marketing strategy. In practice, it is not uncommon for women to be categorized into three trinities, namely, girl, wife, and entertainer. What's worse, this is justified and reproduced by various media. The Gadis Kretek novel is a literary work that juxtaposes the female body with cigarette advertisements. This research was conducted to uncover how women's bodies are selected, used, and displayed for marketing activities of cigarette products that are attached to men by society and become a symbol of masculinity. The method that will be used as a data analysis tool is Norman Fairclough's critical discourse analysis, which focuses on aspects of linguistic practice, discursive practice, and social practice. The results of this study indicate that in product promotion, the female body is used as a desire production machine that will attract potential buyers. Women in ad frames are also categorized based on the Girl-Wife-Entertainer trinity, where the three of them have their own identities but are still presented as complements to men. From this research, it can be seen that literary works also commodify discourses on beauty and the female body. The female body seems to be an affirmation of the construction of masculinity.
Analysis on the Materials Used in Weaving Jewelry Design
Authors: Xia Du , Yao Xu
Published: January 2024

The present study discusses the use of materials in the weaving jewelry, weaving jewelry is a type of jewelry that has a structure or texture similar to the textiles works. Although the practice of weaving jewelry is evident, there are many styles of weaving jewelry around the world, many researches talk about the designs, methods or structures of the weaving jewelries but few comprehensive overview of the materials involved. This study is a qualitative research method, bibliographical and scientific literature review were carried out as well as consulting collections of artists and designers, currently working with jewelry. This study takes the attempt of weaving materials in jewelry design as the theme, talking about how to make weaving materials unique and beautiful.
PHYSICAL AND CHEMICAL CHARACTERISTICS OF AQUEOUS COLLOIDAL INFUSIONS OF MEDICINAL PLANTS CONTAINING HUMIC ACIDS
Authors: PETROV GLEB V. , GAIDASHEV IVAN A. , SYROESHKIN ANTON V.
Published: January 2024

Objective: Study of physical and chemical activity of biologically active substances containing humic complexes (HCs). Comparison of various preparations available on the market. Development of a modern express method of quality control.
Methods: Preparations containing HCs manufactured by Biotechnology System, BIODORON, Faberlic, etc. Built-in flux density sensor TES-92 (TES Electrical Electronic Corp., Taipei, Taiwan), which was used to determine the flux density of radio thermal emission in the gigahertz range. Zetasizer Nano ZSP (Malvern Panalytical, Worcestershire, UK) was used to determine the size of nanoparticles in preparations containing the HCs and MP with humic acids (HAs).
Results: In the course of experiments for studying the intrinsic radiothermal emission of HAs preparations, differences were found between HAs from different manufacturers; for example, HAs produced by a biotechnology system with a flux density of 35±5 µW/m2 at 37 °C differs several times from similar preparations produced by other companies. When diluting HAs from Biotechnology System 10, 100 and 1000 times, the emissivity of the preparations is preserved. Also, with the expiration of the 2 y shelf life of the preparation, as stated by the manufacturer, a sharp drop in emissivity of 20 times is observed.
Conclusion: The radiothermal activity of HAs preparations revealed during the experiments allows the developing a method that can be utilized to control the quality of manufactured products, as well as control the expiration dates of preparations without opening the primary package.
FABRICATION OF NANOSTRUCTURED IRON AND ZINC PARTICLES BY DIOSPYROS CHLOROXYLON (ROXB.) LEAF EXTRACT: CHARACTERIZATION, ADSORPTION MODELING AND CARCINOGENIC DYE ADSORPTION APPLICATIONS
Authors: RAO CHANDANA NARASIMHA , SUJATHA M.
Published: January 2024

Objective: The discharge of these synthetic food dyes, such as sunset yellow and tartrazine, into industrial wastewater can lead to significant environmental and health issues. Its removal through effective adsorption presents an economical and efficient solution. Hence this study proposed to fabricate metal nanoparticles for the adsorption of carcinogenic dyes.
Methods: The fabrication of iron and zinc nanoparticles employed the green synthesis methodology, utilizing an aqueous extract of Diospyros chloroxylon (Roxb.) as a reducing agent. The fabricated nanoparticles were characterized using TEM (Transmission Electron Microscopy), EDX (Energy-Dispersive X-ray Spectroscopy), SEM (Scanning Electron Microscopy), FTIR (Fourier-Transform Infrared Spectroscopy), and UV-Visible Spectroscopy. The nanoparticles were studied for its efficiency for the adsorption of carcinogenic dyes such as tartrazine and Sunset Yellow.
Results: The iron nanoparticles were noticed to be uniformly distributed rod-shaped particles having smooth surfaces with 23-51 nm size range and an average particle size of 34 nm. Whereas the iron nanoparticles were noticed to be uniformly distributed spherical to oval shape with 35 nm to 68 nm size range and an average particle size 53 nm. The XRD results confirm that the iron nanoparticles were rhombohedral phase structure with 71.91 % of elemental iron whereas the zinc nanoparticles were noticed to be hexagonal Wurtzite phase structure having 69.4 % of metallic zinc. These synthesized nanoparticles were applied for the removal of sunset yellow and tartrazine dyes were investigated and found more than 90 % was removed. Adsorption isotherm study was best fitted with Langmuir model, and the maximal adsorption capacity was found to be 52.18 and 75.04 mg/g for sunset yellow using iron and zinc nanoparticles, whereas tartrazine maximum adsorption capacity was noticed to be 69.96 and 84.24 mg/g for iron and zinc nanoparticles. The adsorption reaction follows pseudo-first-order kinetics with high correlation coefficient. Repeated cycles of regeneration, reuse and stability showed very high removal efficiency and stability.
Conclusion: The biosynthesis of metal nanoparticles demonstrates substantial promise for applications in environmental protection.
LIGAND-BASED VIRTUAL SCREENING OF FDA-APPROVED DRUGS TO IDENTIFY NEW INHIBITORS AGAINST LACTATE DEHYDROGENASE ENZYME OF MALARIA PARASITES
Authors: ODHAR HASANAIN ABDULHAMEED , HASHIM AHMED FADHIL , HUMADI SUHAD SAMI , AHJEL SALAM WAHEED
Published: January 2024

Objective: The aim of this study is to computationally repurpose FDA-approved drugs as potential inhibitors of the Plasmodium falciparum lactate dehydrogenase (PfLDH) by competing with the cofactor NADH.
Methods: In this in silico study, we have virtually screened a library of FDA-approved drugs for structural similarity to the dihydro nicotinamide adenine dinucleotide (NADH). Then, the top hits were further assessed for clinical safety and by application of molecular docking and dynamics simulation.
Results: Ligand-based virtual screening reports that the antibiotic Novobiocin has a good similarity to the cofactor NADH with a score of 0.7. Also, molecular docking study indicates that Novobiocin may has the ability to interact with PfLDH enzyme with a docking energy of-8.8 Kcal/mol. However, during molecular dynamics (MD) simulation, the mean ligand proximity root mean square deviation (RMSD) and binding energy for Novobiocin were 4.3 Angstrom and-37.45 Kcal/mol, respectively. These MD simulation parameters are inferior to those recorded for NADH molecule during 50 nanosecond intervals.
Conclusion: The antibiotic Novobiocin may serve as a potential lead candidate toward the design of novel antimalarial agents. However, further evaluation of Novobiocin may be recommended to affirm its capacity against PfLDH enzyme.
VIRTUAL SCREENING OF FDA-APPROVED DRUGS BY MOLECULAR DOCKING AND DYNAMICS SIMULATION TO RECOGNIZE POTENTIAL INHIBITORS AGAINST MYCOBACTERIUM TUBERCULOSIS ENOYL-ACYL CARRIER PROTEIN REDUCTASE ENZYME
Authors: ODHAR HASANAIN ABDULHAMEED , HASHIM AHMED FADHIL , AHJEL SALAM WAHEED , HUMADI SUHAD SAMI
Published: January 2024

Objective: This in silico study is aimed at identification of new possible inhibitors against Mycobacterium tuberculosis InhA enzyme by screening a library of FDA-approved drugs.
Methods: In this in silico study, a library of FDA-approved drugs was screened by molecular docking against the monomer of enoyl-acyl carrier protein reductase to recognize potential inhibitors. Then, those best drugs with minimum docking energy were subjected to molecular dynamics simulation.
Results: Out of the top ten docking hits, only revefenacin was able to maintain the closet proximity to InhA enzyme binding pocket during the two rounds of dynamics simulation. Analysis of molecular dynamics (MD) simulation data indicated that the antimuscarinic drug revefenacin has a ligand movement Root-Mean-Square Deviation (RMSD) that didn’t exceed 4 Angstrom. Also, in this MD study, revefenacin has a superior binding energy of -35.59 Kcal/mol as compared to -13.88 Kcal/mol for the other hit ergotamine. These favorable MD simulation records for revefenacin can be explained by its ability to continuously interact with enzyme binding pocket by two hydrogen bonds.
Conclusion: We report that the antimuscarinic drug revefenacin may have the potential to inhibit the enoyl-acyl carrier protein reductase for Mycobacterium tuberculosis. However, these preliminary results must be further evaluated by in vitro and in vivo studies.
BI-LAMINATED ORAL DISINTEGRATING FILM FOR SYMPTOMATIC TREATMENT OF VIRAL NASOPHARYNGITIS: FORMULATION, CHARACTERIZATION, TASTE MASKING, AND STABILITY STUDIES
Authors: RIZK MERNA A. , TEAIMA MAHMOUD H. , ABDELMONEM REHAB , EL-NABARAWI MOHAMED A. , ELHABAL SAMMAR FATHY
Published: January 2024

Objective: Nasopharyngitis (NP) is one of the most common upper respiratory tract infections (URTIs) brought on by viral infections and requires symptomatic treatment. In this study, a new approach to delivering drugs was developed, which is a bi-laminated oral disintegrating film (ODF) containing dextromethorphan hydrobromide (DEX), phenylephrine hydrochloride (PE), and methylcobalamin (MeCbl) to support the symptomatic treatment of NP. Yet, the extreme bitterness of DEX and PE required a taste-masking technique before ODF formulation to enhance patient compliance.
Methods: Various complexing agents were tried at different ratios to mask the bitter taste of the drug(s). DEX-PE ODFs were formulated using the solvent casting procedure. A 31.21 full factorial design was performed to characterize DEX-PE ODFs, where the effects of polymer grade and plasticizer type were evaluated on the disintegration time (DT) and the percentage of drugs released after 10 min (Q10).
Results: Complexation with maltodextrin (MD) and ion exchange resin (Kyron T-314) could successfully mask the bitter taste at a ratio of 1:2:2 of drugs, MD, and Kyron T-314, respectively. The ODF optimized formula (F4) recorded the least DT (5±0.5 s) and highest Q10 (96.7±2.1%) and (97.4±1.9%) for DEX and PE, respectively. F4 was then combined with the second film layer containing MeCbl to develop the bi-laminated ODF (B1), which was later evaluated and subjected to stability studies.
Conclusion: In conclusion, a taste-masked, bi-laminated ODF could be successfully developed for the symptomatic treatment of NP.