bluuebunny/crossref_metadata_2025 huggingface dataset:
Detection of the recently emerged synthetic cannabinoid 5F–MDMB‐PICA in ‘legal high’ products and human urine samples
Authors: Mogler Lukas , Franz Florian , Rentsch Daniel , Angerer Verena , Weinfurtner Georg , Longworth Mitchell , Banister Samuel D. , Kassiou Michael , Moosmann Bjoern , Auwärter Volker
Published: April 2017

Indole or indazole‐based synthetic cannabinoids (SCs) bearing substituents derived from valine or tert‐leucine are frequently abused new psychoactive substances (NPS). The emergence of 5F–MDMB‐PICA (methyl N‐{[1‐(5‐fluoropentyl)‐1H–indol‐3‐yl]carbonyl}‐3‐methylvalinate) on the German drug market is a further example of a substance synthesized in the context of scientific research being misused by clandestine laboratories by adding it to ‘legal high’ products. In this work, we present the detection of 5F–MDMB‐PICA in several legal high products by gas chromatography–mass spectrometry (GC–MS) analysis. To detect characteristic metabolites suitable for a proof of 5F–MDMB‐PICA consumption by urine analysis, pooled human liver microsome (pHLM) assays were performed and evaluated using liquid chromatography–tandem mass spectrometry (LC–MS/MS) and liquid chromatography quadrupole time‐of‐flight mass spectrometry (LC‐QToF‐MS) techniques to generate reference spectra of the in vitro phase I metabolites. The in vivo phase I metabolism was investigated by the analysis of more than 20 authentic human urine specimens and compared to the data received from the pHLM assay. Biotransformation of the 5‐fluoropentyl side chain and hydrolysis of the terminal methyl ester bond are main phase I biotransformation steps. Two of the identified main metabolites formed by methyl ester hydrolysis or mono‐hydroxylation at the indole ring system were evaluated as suitable urinary biomarkers and discussed regarding the interpretation of analytical findings. Exemplary analysis of one urine sample for 5F–MDMB‐PICA phase II metabolites showed that two of the main phase I metabolites are subject to extensive glucuronidation prior to renal excretion. Therefore, conjugate cleavage is reasonable for enhancing sensitivity. Commercially available immunochemical pre‐tests for urine proved to be unsuitable for the detection of 5F–MDMB‐PICA consumption. Copyright © 2017 John Wiley & Sons, Ltd.
Rainfall variability counteracts N addition by promoting invasiveLonicera maackiiand extending phenology in prairie
Authors: Schuster Michael J. , Dukes Jeffrey S.
Published: April 2017

Although encroaching woody plants have reduced the global extent of grasslands, continuing increases in soil nitrogen availability could slow this trend by favoring resident herbaceous species. At the same time, projected increases in rainfall variability could promote woody encroachment by aligning spatiotemporal patterns of soil moisture availability with the needs of woody species. We evaluated the responses of two deciduous woody species to these simulated environmental changes by planting seedlings ofQuercus palustrisandLonicera maackiiinto tallgrass prairie communities grown under a factorial combination of increased rainfall variability and nitrogen addition.Lonicera maackiigrowth was reduced 20% by nitrogen addition, and increased rainfall variability led to 33% larger seedlings, despite greater competition for light and soil resources. In contrast,Q. palustrisgrowth showed little response to either treatment. Increased rainfall variability allowed both species to retain their leaves for an additional 6.5 d in autumn, potentially in response to wetter end‐of‐season shallow soils. Our findings suggest increases in rainfall variability will counteract the inhibitory effect of nitrogen deposition on growth ofL. maackii, extend autumn phenology, and promote the encroachment of some woody species into grasslands.
Are long‐term widespread avian body size changes related to food availability? A test using contemporaneous changes in carotenoid‐based color
Authors: Little Roellen , Gardner Janet L. , Amano Tatsuya , Delhey Kaspar , Peters Anne
Published: April 2017

Recent changes in global climate have been linked with changes in animal body size. While declines in body size are commonly explained as an adaptive thermoregulatory response to climate warming, many species do not decline in size, and alternative explanations for size change exist. One possibility is that temporal changes in animal body size are driven by changes in environmental productivity and food availability. This hypothesis is difficult to test due to the lack of suitable estimates that go back in time. Here, we use an alternative, indirect, approach and assess whether continent‐wide changes over the previous 100 years in body size in 15 species of Australian birds are associated with changes in their yellow carotenoid‐based plumage coloration. This type of coloration is strongly affected by food availability because birds cannot synthesize carotenoids and need to ingest them, and because color expression depends on general body condition. We found significant continent‐wide intraspecific temporal changes in body size (wing length) and yellow carotenoid‐based color (plumage reflectance) for half the species. Direction and magnitude of changes were highly variable among species. Meta‐analysis indicated that neither body size nor yellow plumage color showed a consistent temporal trend and that changes in color were not correlated with changes in size over the past 100 years. We conclude that our data provide no evidence that broad‐scale variation in food availability is a general explanation for continent‐wide changes in body size in this group of species. The interspecific variability in temporal changes in size as well as color suggests that it might be unlikely that a single factor drives these changes, and more detailed studies of museum specimens and long‐term field studies are required to disentangle the processes involved.
Context‐dependent resistance of freshwater invertebrate communities to drying
Authors: Datry Thibault , Vander Vorste Ross , Goïtia Edgar , Moya Nabor , Campero Melina , Rodriguez Fabiola , Zubieta Jose , Oberdorff Thierry
Published: April 2017

More freshwater ecosystems are drying in response to global change thereby posing serious threat to freshwater biota and functions. The production of desiccation‐resistant forms is an important adaptation that helps maintain biodiversity in temporary freshwaters by buffering communities from drying, but its potential to mitigate the negative effects of drying in freshwater ecosystems could vary greatly across regions and ecosystem types. We explored this context dependency by quantifying the potential contribution of desiccation‐resistance forms to invertebrate community recovery across levels of regional drying prevalence (defined as the occurrence of drying events in freshwaters in a given region) and ecosystem types (lentic, lotic) in temporary neotropical freshwaters. We first predicted that regional drying prevalence influences the selection of species with desiccation‐resistant forms from the regional species pools and thus increases the ability of communities to recover from drying. Second, we predicted lentic freshwaters harbor higher proportions of species with desiccation‐resistant forms compared to lotic, in response to contrasted hydrologic connectivity. To test these predictions, we used natural experiments to quantify the contribution of desiccation‐resistant forms to benthic invertebrate community recovery in nine intermittent streams and six geographically isolated temporary wetlands from three Bolivian regions differing in drying prevalence. The contribution of desiccation‐resistant forms to community recovery was highest where regional drying prevalence was high, suggesting the species pool was adapted to regional disturbance regimes. The contribution of desiccation‐resistant forms to community recovery was lower in streams than in wetlands, emphasizing the importance of hydrologic connectivity and associated recolonization processes from in‐stream refuges to recovery in lotic systems. In all regions, the majority of functional traits were present in desiccation‐resistant taxa indicating this adaptation may help maintain ecosystem functions by buffering communities from the loss of functional traits. Accounting for regional context and hydrologic connectivity in community recovery processes following drying can help refine predictions of freshwater biodiversity response to global change.
The distribution, diversity, and conservation status of Cycas in China
Authors: Zheng Ying , Liu Jian , Feng Xiuyan , Gong Xun
Published: April 2017

As ancient gymnosperm and woody plants, cycads have survived through dramatic tectonic activities, climate fluctuation, and environmental variations making them of great significance in studying the origin and evolution of flora biodiversity. However, they are among the most threatened plant groups in the world. The principal aim of this review is to outline the distribution, diversity, and conservation status of Cycas in China and provide suggestions for conservation practices. In this review, we describe the taxonomy, distribution, and conservation status of Cycas in China. By comparing Chinese Cycas species with its relatives worldwide, we then discuss the current genetic diversity, genetic differentiation of Cycas, and try to disentangle the potential effects of Quaternary climate changes and topographical events on Cycas. We review conservation practices from both researchers and practitioners for these rare and endangered species. High genetic diversity at the species level and strong genetic differentiation within Cycas have been observed. Most Cycas species in southwest China have experienced population retreats in contrast to the coastal Cycas's expansion during the Quaternary glaciation. Additionally, human activities and habitat fragmentation have pushed these endangered taxa to the brink of extinction. Although numerous efforts have been made to mitigate threats to Cycas survival, implementation and compliance monitoring in protection zones are currently inadequate. We outline six proposals to strengthen conservation measures for Cycas in China and anticipate that these measures will provide guidelines for further research on population genetics as well as conservation biology of not only cycads but also other endangered species worldwide.
Variation in reach‐scale thalweg‐migration intensity in a braided reach of the lower Yellow River in 1986–2015
Authors: Li Jie , Xia Junqiang , Zhou Meirong , Deng Shanshan , Zhang Xiaolei
Published: April 2017

Thalweg migration of an alluvial river plays a key role in channel evolution, which may influence the effect of existing river training works and biodiversity on floodplains, and cause losses in riparian land and property. The braided reach of the Lower Yellow River underwent continuous channel aggradation during the period from 1986 to 1999, and then remarkable channel degradation in 1999–2015 owing to the state of operation of the Xiaolangdi Reservoir in 1999. Here we quantify associated thalweg migration changes and identify the key influencing factor in the braided reach. Thalweg‐migration distances and intensities at section‐ and reach‐scales were calculated during the past 30 years from 1986 to 2015, in order to investigate the characteristics of thalweg migration in the reach. There was a 47% reduction in the reach‐scale thalweg‐migration distance and a 35% reduction in the corresponding migration intensity after the reservoir operation. It is also revealed that fluvial erosion intensity is a dominant factor in controlling the thalweg migration, based on the investigation into various influencing factors in the study reach. The thalweg‐migration intensity of the braided reach can be expressed as a power function of the previous four‐year average fluvial erosion intensity. The calculated thalweg‐migration intensities in 1986–2015 using the proposed relation generally agree with the observed data. Copyright © 2017 John Wiley & Sons, Ltd.
Structural and thermal controls of rockfall frequency and magnitude within rockwall–talus systems (Swiss Alps)
Authors: Messenzehl Karoline , Dikau Richard
Published: April 2017

Both from a systemic and natural hazard perspective, it is essential to understand the causes and frequency of rockfalls in mountain terrain and to predict the block sizes deposited at specific locations. Commonly, rockfalls are studied either retrospectively, using talus slopes, or directly by rockwall surveys. Nevertheless, our understanding of rockfall activity, particularly at the lower magnitude spectrum, is still incomplete. Moreover, the explanatory framework is rarely addressed explicitly. In this study, we investigate two rockwall–talus systems in the Swiss Alps to estimate the rockfall frequency–magnitude pattern and their key controls. We present a holistic approach that integrates deductive geotechnical and thermal investigations of the source rockwalls with abductive talus‐based explanations of rockfall volume and frequency.

The rockwalls' three‐dimensional (3D) joint pattern indicates that 75% of the blocks may be released as debris fall (< 14 m3) and boulder falls (14–61 m3), which is mirrored in the corresponding talus material. Using two‐year records of near‐surface rockwall temperatures as input for a 1D heat conduction model underlines the destabilizing role of seasonal ice segregation. Deepest frost cracking of 300 cm may occur on the north‐northeast (NNE)‐exposed, snow‐rich rockwall, with peaks at the outermost surface. The synthesis of all data suggests that infrequent, large planar slides (approximately every 250 years) overlain by smaller, more frequent wedge and toppling failures (approximately every 17–50 years) as well as high‐frequency flake‐like clasts (3–6 events/year) characterize the rockfall frequency–magnitude pattern at Hungerli Peak.

Here, we argue that small‐size rockfalls need more scientific attention, particularly in discontinuous permafrost zones. Our study emphasizes that future frequency–magnitude research should ideally incorporate site‐specific structural and thermal properties, rather than just focusing on climatic or meteorological triggers. We discuss how holistic rockwall–talus approaches, as proposed here, could help to increase our process understanding of rockfalls in mountain environments. Copyright © 2017 John Wiley & Sons, Ltd.
Assessment of connectivity in a water‐stressed wetland (Kaabar Tal) of Kosi‐Gandak interfan, north Bihar Plains, India
Authors: Singh Manudeo , Tandon Sampat K. , Sinha Rajiv
Published: April 2017

Landscape elements respond to the processes acting on them, and this response connects with neighboring landscape units. The propagation, superposition, and interference of these responses are functions of the connectivity among the landscape units. Such landscape units are referred to as ‘Connectivity Response Units’ or CRUs that are in turn influenced by topography and landuse/landcover (LULC). The CRUs are obtained by the application of diffusion‐kernel based smoothing technique over the connectivity potential maps. A framework has been designed using the CRUs to understand the impacts of changing LULC on the connectivity structure in a relatively flat terrain under pre‐ and post‐monsoon scenarios. The proposed framework has been applied to a water‐stressed wetland occurring in an interfan setting in north Bihar plains, eastern India. It has also been demonstrated that CRUs can be used as a viable option for understanding the seasonal and temporal dynamics of connectivity structure in and around such wetlands and for guiding a rehabilitation strategy for such fragile ecosystems. Copyright © 2017 John Wiley & Sons, Ltd.
Stent‐mediated gene and drug delivery for cardiovascular disease and cancer: A brief insight
Authors: Krishnagopal Akshaya , Reddy Aakash , Sen Dwaipayan
Published: April 2017

This review concisely recapitulates the different existing modes of stent‐mediated gene/drug delivery, their considerable advancement in clinical trials and a rationale for other merging new technologies such as nanotechnology and microRNA‐based therapeutics, in addition to addressing the limitations in each of these perpetual stent platforms. Over the past decade, stent‐mediated gene/drug delivery has materialized as a hopeful alternative for cardiovascular disease and cancer in contrast to routine conventional treatment modalities. Regardless of the phenomenal recent developments achieved by coronary interventions and cancer therapies that employ gene and drug‐eluting stents, practical hurdles still remain a challenge. The present review highlights the limitations that each of the existing stent‐based gene/drug delivery system encompasses and therefore provides a vision for the future with respect to discovering an ideal stent therapeutic platform that would circumvent all the practical hurdles witnessed with the existing technology. Further study of the improvisation of next‐generation drug‐eluting stents has helped to overcome the issue of restenosis to some extent. However, current stent formulations fall short of the anticipated clinically meaningful outcomes and there is an explicit need for more randomized trials aiming to further evaluate stent platforms in favour of enhanced safety and clinical value. Gene‐eluting stents may hold promise in contributing new ideas for stent‐based prevention of in‐stent restenosis through genetic interventions by capitalizing on a wide variety of molecular targets. Therefore, the central consideration directs us toward finding an ideal stent therapeutic platform that would tackle all of the gaps in the existing technology.
Changes in chondrolabral mechanics, coverage, and congruency following peri‐acetabular osteotomy for treatment of acetabular retroversion: A patient‐specific finite element study
Authors: Knight Spencer J. , Abraham Christine L. , Peters Christopher L. , Weiss Jeffrey A. , Anderson Andrew E.
Published: April 2017

Using a validated finite element (FE) protocol, we quantified cartilage and labrum mechanics, congruency, and femoral coverage in five male patients before and after they were treated for acetabular retroversion with peri‐acetabular osteotomy (PAO). Three‐dimensional models of bone, cartilage, and labrum were generated from computed tomography (CT) arthrography images, acquired before and after PAO. Walking, stair‐ascent, stair‐descent, and rising from a chair were simulated. Cartilage and labrum contact stress, contact area, and femoral coverage were calculated overall and regionally. Mean congruency (average of local congruency values for FE nodes in contact) and peak congruency (most incongruent node in contact) were calculated overall and regionally. Load supported by the labrum was represented as a raw change in the ratio of the applied force transferred through the labrum and percent change following surgery (calculated overall only). Considering all activities, following PAO, mean acetabular cartilage contact stress increased medially, superiorly, and posteriorly; peak stress increased medially and posteriorly. Peak labrum stresses decreased overall and superiorly. Acetabular contact area decreased overall and laterally, and increased medially. Labral contact area decreased overall, but not regionally. Load to the labrum decreased. Femoral head coverage increased overall, anterolaterally, and posterolaterally, but decreased anteromedially. Mean congruency indicated the hip became less congruent overall, anteriorly, and posteriorly; peak congruency indicated a less congruent joint posteriorly. Clinical relevance: Medialization of contact and reductions in labral loading following PAO may prevent osteoarthritis, but this procedure increases cartilage stresses, decreases contact area, and makes the hip less congruent, which may overload cartilage. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:2567–2576, 2017.
Percutaneous Epiphysiodesis Using Transphyseal Screws: A Case Series Demonstrating High Efficacy
Authors: Dodwell Emily R. , Garner Matthew R. , Bixby Elise , Luderowski Eva M. , Green Daniel W. , Blanco John S. , Widmann Roger F.
Published: April 2017

Background

Percutaneous epiphysiodesis using transphyseal screws (PETS) has been associated with implant failure, implant prominence, angular deformities, and delayed growth inhibition.

Questions/Purposes

The aim of this study was to assess the complication rate and efficacy (defined as actual growth inhibition divided by expected growth inhibition) of PETS and to identify factors associated with improved efficacy.

Methods

Patients who underwent distal femoral and/or proximal tibial PETS between January 2007 and June 2014 were identified. Complications, efficacy, and final limb-length discrepancy (LLD) were calculated using multipliers and inhibition rates based on previous growth. Associations between efficacy and screw insertion angle (SIA), body mass index, and number of threads crossing the physis were calculated.

Results

Eight-two patients (126 treated physes) were included. The mean pre-operative LLD was 27.7 mm (SD = 7.5). Following epiphysiodesis, 15 had temporary pain (18%), five had temporary effusion (6.1%), four had broken implants (4.9%), four developed mild angulation (4.9%), and three had failed epiphysiodesis requiring revision (3.7%). Thirty-one underwent screw removal ( n = 31, 38%). Mean LLD at maturity was 17.3 mm (SD = 5.8 mm). Mean efficacy at the distal femur was 97% (SD = 46%), at the proximal tibia was 108% (SD = 66%) and was 103% (SD = 57%) overall. Increased screw threads across the lateral proximal tibial physis (Spearman's correlation coefficient = 0.67; 95% CI = 0.40–0.94) and higher BMI (Spearman's correlation coefficient = 0.55; 95% CI = 0.34–0.77) were positively associated with increased efficacy.

Conclusions

The efficacy of PETS may be more favorable than previously reported. Only 3.7% had serious complications requiring revision epiphysiodesis, lower than previous reports. Attention to sufficient screw threads across the physis may be important in optimizing PETS results.
Fever after peripheral blood stem cell infusion in haploidentical transplantation with post-transplant cyclophosphamide
Authors: Arango Marcos , Combariza Juan F.
Published: April 2017

Objective/background:

Noninfection-related fever can occur after peripheral blood stem cell infusion in haploidentical hematopoietic stem cell transplantation with post-transplant cyclophosphamide. The objective of this study was to analyze the incidence of fever and characterize some clinical features of affected patients.

Methods:

A retrospective case-series study with 40 patients who received haploidentical hematopoietic stem cell transplantation was carried out.

Results:

Thirty-three patients (82.5%) developed fever; no baseline characteristic was associated with its development. Median time to fever onset was 25.5 h (range, 9.5–100 h) and median peak temperature was 39.0 °C (range, 38.1–40.5 °C). Not a single patient developed hemodynamic or respiratory compromise that required admission to the intensive care unit. Fever was not explained by infection in any case. Ninety-one percent of the febrile episodes resolved within 96 h of cyclophosphamide administration. No significant difference in overall survival, event-free survival, or graft versus host disease-free/relapse-free survival was found in the group of febrile individuals after peripheral blood stem cell infusion.

Conclusion:

Fever after peripheral blood stem cell infusion in this clinical setting was common; it usually subsides with cyclophosphamide administration. The development of fever was not associated with an adverse prognosis.
Analysis of expression of transcription factors in early human retina
Authors: Chen Jing , Ma Lixiang , Wang Songtao , Wang Xiaobing , Sun Yan , Gao Lu , Li Jin , Zhou Guomin
Published: April 2017

The retina originates in the central nervous system. Due to its accessibility and simplicity, the retina has become an invaluable model for studying the basic mechanisms involved in development. To date, considerable knowledge regarding the interactions among genes that coordinate retinal development has been gained from extensive research in model animals. However, our understanding of retinal development in humans remains undeveloped. Here, we analyze the expression of transcription factors that are involved in the early development of the retina in human embryos at 6–12 weeks post‐conception. Our work demonstrates that early developing neural retinas can be divided into two layers, the outer and inner neuroblast layers. Eye‐field transcription factors and those related to the early development of the retina have distinct expression patterns in the two layers. Cell‐type‐specific transcription factors emerge at 8 weeks. These data provide clear and systemic structures for early retinal development in human.
Foundations of High-Energy-Density Physics
Authors: Larsen Jon
Published: April 2017

High-energy-density physics explores the dynamics of matter at extreme conditions. This encompasses temperatures and densities far greater than we experience on Earth. It applies to normal stars, exploding stars, active galaxies, and planetary interiors. High-energy-density matter is found on Earth in the explosion of nuclear weapons and in laboratories with high-powered lasers or pulsed-power machines. The physics explored in this book is the basis for large-scale simulation codes needed to interpret experimental results whether from astrophysical observations or laboratory-scale experiments. The key elements of high-energy-density physics covered are gas dynamics, ionization, thermal energy transport, and radiation transfer, intense electromagnetic waves, and their dynamical coupling. Implicit in this is a fundamental understanding of hydrodynamics, plasma physics, atomic physics, quantum mechanics, and electromagnetic theory. Beginning with a summary of the topics and exploring the major ones in depth, this book is a valuable resource for research scientists and graduate students in physics and astrophysics.
Copyright and International Negotiations
Authors: Chen Ge
Published: April 2017

Copyright and International Negotiations provides a historical study of the development of Chinese copyright law in terms of China's contemporary political economy and the impact that international copyright law has had. The analysis shows how China's copyright system is intertwined with censorship and international copyright law and how this has affected freedom of expression. China still enforces an old censorship regime that clamps down on free expression despite a modern system of copyright rules which should function as an engine of free expression. The book explores the development and architecture of Chinese copyright law in parallel with international copyright law, clarifies China's nuanced patterns of the control of free expression through copyright law, and identifies a breakthrough for neutralising the impact of China's censorship policies through copyright law.
The Urbanism of Exception
Authors: Murray Martin J.
Published: April 2017

This book challenges the conventional (modernist-inspired) understanding of urbanization as a universal process tied to the ideal-typical model of the modern metropolis with its origins in the grand Western experience of city-building. At the start of the twenty-first century, the familiar idea of the 'city' - or 'urbanism' as we know it - has experienced such profound mutations in both structure and form that the customary epistemological categories and prevailing conceptual frameworks that predominate in conventional urban theory are no longer capable of explaining the evolving patterns of city-making. Global urbanism has increasingly taken shape as vast, distended city-regions, where urbanizing landscapes are increasingly fragmented into discontinuous assemblages of enclosed enclaves characterized by global connectivity and concentrated wealth, on the one side, and distressed zones of neglect and impoverishment, on the other. These emergent patterns of what might be called enclave urbanism have gone hand-in-hand with the new modes of urban governance, where the crystallization of privatized regulatory regimes has effectively shielded wealthy enclaves from public oversight and interference.
Calvin's Political Theology and the Public Engagement of the Church
Authors: Tuininga Matthew J.
Published: April 2017

In Calvin's Political Theology and the Public Engagement of the Church, Matthew J. Tuininga explores a little appreciated dimension of John Calvin's political thought, his two kingdoms theology, as a model for constructive Christian participation in liberal society. Widely misunderstood as a proto-political culture warrior, due in part to his often misinterpreted role in controversies over predestination and the heretic Servetus, Calvin articulated a thoughtful approach to public life rooted in his understanding of the gospel and its teaching concerning the kingdom of God. He staked his ministry in Geneva on his commitment to keeping the church distinct from the state, abandoning simplistic approaches that placed one above the other, while rejecting the temptations of sectarianism or separatism. This revealing analysis of Calvin's vision offers timely guidance for Christians seeking a mode of faithful, respectful public engagement in democratic, pluralistic communities today.
Grid-Connected Photovoltaic Power Generation
Authors: Gevorkian Peter
Published: April 2017

Covering technical design and construction aspects as well as financial analysis and risk assessment, this professional reference work provides a comprehensive overview of solar power technology. Whether or not you have a technology background, this essential guide will help you to understand the design, construction, financial analysis, and risk assessment of solar power technology. The first two chapters present an uncomplicated overview of solar power technology physics, solar cell technology, applications, and equipment. In subsequent chapters, readers are introduced to fundamental econometric analysis in such a way that will allow anyone, whether or not they have a background in finance, to become familiar with the fundamental costing and financing of large scale solar power programs. This book is essential reading for anyone involved with solar power project development, and is suitable for both graduate students and professionals.
A Southern View on the Tuareg Rebellions in Mali
Authors: Kone Kassim
Published: April 2017

Since Mali’s independence in 1960, the Tuareg, a minority ethnic group, have staged successive rebellions, with the major ones occurring in 1963, 1990, 2006, and 2012. While discussions of “the Tuareg issue” have sometimes led both the Malian and the international press, as well as scholars, to make inaccurate generalizations, it is true that almost all the armed conflicts of the past fifty years in Mali were originated by people of the Tuareg group. Therefore, many of their Malian compatriots hold the Tuareg people responsible for the destruction of life and human rights violations that have taken place since the beginning of 2012. This article focuses on the events of 2012 and their aftermath and explores some social, cultural, and political differences between northern Tuareg and southern Bamana peoples in particular. It asks two specific questions: Is there something about Tuareg society, culture, and politics (i.e., Tuareg identity) that causes an incompatibility with the Mali Republic? And if not, where has the Malian government failed through the successive regimes since independence?
Global Media and Local Verbal Art Representations of Northern Malian Tuareg
Authors: Rasmussen Susan J.
Published: April 2017

This article offers a critique of widely disseminated portrayals of northern Malian Tuareg by outside media, which tend to portray all Tuareg as warriors and criminals and to project pseudo-scientific concepts of “race” onto relationships between Tuareg and other Malians, recalling the now discredited colonial “Hamitic Myth” in Rwanda. It also analyzes local oral historical accounts that present themes of Mali as both a protected fortress and welcoming crossroads, a country that both resists and absorbs intruders, and that also express concepts of identity based on language, culture, and flexible social affiliation. The article is based partly on interviews with internationally known local musicians who function as mediating “third voices,” and concludes with a discussion of wider implications of these findings for notions of voice, authority, and the mutual construction of ideas of Africa.
Political Participation and Mobilization after Mali’s 2012 Coup
Authors: Whitehouse Bruce
Published: April 2017

If the sudden downfall of Mali’s officially democratic system in early 2012 surprised many observers, the failings of the Malian state—including public disaffection with the political process, weak rule of law, and inadequate delivery of basic services—were widely known both at home and abroad. Focusing on activists based in Bamako, this article assesses Malian civil society’s response to these challenges since the March 2012 military coup and considers prospects for wider political engagement by the Malian public.
Lexicography in-your-face: The active semantics of Pastaza Quichua ideophones
Authors: Nuckolls Janis B. , Swanson Tod D. , Shelton Diana , Rice Alexander , Hatton Sarah
Published: April 2017

We argue that a multimodal approach to defining a depictive class of words called ‘ideophones’ by linguists is essential for grasping their meanings. Our argument for this approach is based on the formal properties of Pastaza Quichua ideophones, which set them apart from the non-ideophonic lexicon, and on the cultural assumptions brought by speakers to their use. We analyze deficiencies in past attempts to define this language's ideophones, which have used only audio data. We offer, instead, an audiovisual corpus which we call an ‘antidictionary’, because it defines words not with other words, but with clips featuring actual contexts of use. The major discovery revealed by studying these clips is that ideophones’ meanings can be clarified by means of a distinction found in modality and American Sign Language studies. This distinction between speaker-internal and speaker-external perspective is evident in the intonational and gestural details of ideophones’ use.
A NEW STATISTICAL SOLUTION TO THE GENERALITY PROBLEM
Authors: Kampa Samuel
Published: April 2017

The Generality Problem is widely recognized to be a serious problem for reliabilist theories of justification. James R. Beebe's Statistical Solution is one of only a handful of attempted solutions that has garnered serious attention in the literature. In their recent response to Beebe, Julien Dutant and Erik J. Olsson successfully refute Beebe's Statistical Solution. This paper presents a New Statistical Solution that countenances Dutant and Olsson's objections, dodges the serious problems that trouble rival solutions, and retains the theoretical virtues that made Beebe's solution so attractive in the first place. There indeed exists a principled, rigorous, conceptually sparse, and plausible solution to the Generality Problem: it is the New Statistical Solution.
Multi-dimensional Party Competition: Abortion Politics in Ireland
Authors: McGraw Sean
Published: April 2017

While the questions of how parties seek to address (or not) pressing issues are critically important, scholars have generally paid little attention to where issues are addressed within the political system, and the consequences for party competition of that choice. The fact that issues can be addressed within several institutional (i.e. functional) domains and levels – general elections, parliament, referenda, courts, local government, etc. – implies that political parties may address an issue, and thereby interact with one another, in consequentially different ways depending on the institutional arena or level of government wherein they seek resolution. This article describes how Ireland’s parties addressed the electorally volatile issue of abortion via referendum campaigns. The article draws upon multiple sources of evidence to support its findings, including original data based on results from the author’s two parliamentary surveys following the 2007 and 2011 election campaigns.
Efficient offline production of freestanding thin plastic foils for laser-driven ion sources
Authors: Seuferling Sebastian , Haug Matthias Alexander Otto , Hilz Peter , Haffa Daniel , Kreuzer Christian , Schreiber Jörg
Published: April 2017

Modern chirped pulse amplification laser systems with continuously improving controllability and increasing power are about to reach intensities of up to $10^{22}~\text{W}~\text{cm}^{-2}$ and have proven their potential to accelerate ions out of plasma to several tens percent of the speed of light. For enabling application, one important step is to increase the repetition rate at which ion bunches are at the disposal. In particular, techniques used so far for thin foil target production can require several days of preparing reasonable amounts for a single campaign. In this paper we describe the reasonably droplet method which we have tested and improved so that the emerging foils with thicknesses of a few nanometres up to micrometre can be used as targets for laser ion acceleration. Their quality and performance can compete with so far employed techniques thereby enabling the production of hundreds of targets per day.
Competition and propagule density affect sexual and clonal propagation of a weed
Authors: Atwater Daniel Z. , Kim Wonjae , Tekiela Daniel R. , Barney Jacob N.
Published: April 2017

Many introduced species are capable of both sexual and vegetative reproduction. Our understanding of the ecology of such species depends on the trade-offs between vegetative and sexual reproduction and the ecological conditions that favor both modes of reproduction and how those factors influence the population ecology of introduced species. Here, we studied the efficacy of propagation via both seeds and rhizomes in Johnsongrass, a widespread invasive grass whose success is due to its prolific production of shattering seeds and rhizomes, the latter of which are readily dispersed by anthropogenic and natural processes. In a common garden in Virginia, we varied the density of seeds and rhizomes and manipulated whether recruits experienced interspecific competition. Johnsongrass recruited from both seeds and rhizomes. We compared the efficacy of seeds and rhizomes on a per propagule basis and by standardizing them according to their total carbon content. Rhizomes were more efficient than seeds on a per propagule basis, but seeds propagated more efficiently than rhizomes on a per unit of carbon basis, establishing in nearly all plots and obtaining much greater biomass than rhizomes. We also found that rhizomes were subject to stronger negative density dependence than seeds and were more sensitive to site variation and competition. Our results suggest that, provided sufficient dispersal, a single Johnsongrass plant produces enough propagules to establish over more than a hectare, even at relatively low propagule densities. Proper understanding of both seed and vegetative propagation is crucial for understanding the ecology of this and other invasive species that utilize multiple reproductive modes.
Nutritional components can influence hair coat colouration in white dogs
Authors: Watson Adrian , Le Verger Laurence , Guiot Anne-Laure , Feugier Alexander , Biourge Vincent
Published: April 2017

Hair colouration in animals is controlled primarily by inherited factors, with a complex set of genes and genetic variants determining phenotypic expression. The colours in the hair shaft are created initially by the melanocyte cells within the hair bulb which produce and secrete two types of melanin into the hair cortex, black eumelanin and brown pheomelanin. Together these two pigments are responsible for creating the considerable diversity of colour seen in hair across the animal kingdom. In the absence of melanins the hair remains translucent, appearing white to the eye. Colour, or absence thereof, can only be imparted on a hair during its ‘anagen’ or growing phase. During the telogen (resting) phase the colour of the hair is relatively constant, notwithstanding effects of environmental influences such as UV in sunlight, or staining agents. A further environmental factor is nutrition. The intensity of black in the hair of both cats and dogs is known to be influenced by the dietary intake of certain amino acids such as phenylalanine (Phe) and tyrosine (Tyr). However the role of nutrition in hair pigmentation is generally poorly understood. This trial investigated the impact of diet on the commonly observed red discolouration of white coat in dogs. Two panels of 13 Swiss White Shepherd dogs were fed diets containing different concentrations of Phe + Tyr (test diet containing 3.02 g/Mcal versus control 4.82 g/Mcal) and copper (test diet containing 8.93 ppm versus control 13.28 ppm) for four months. Coat colouration was assessed via spectrophotometry using the CIE Lab colour space system (International Commission on Illumination). Dogs fed the reduced Phe + Tyr and copper showed significantly less red coat pigmentation (a* parameter) by the end of the feeding study (P < 0.02). It was concluded that the level of Phe + Tyr not only affects black but also white coat in dogs. Diet can therefore exert an influence on multiple aspects of coat pigmentation.
Utilisation of supplementedl-carnitine for fuel efficiency, as an antioxidant, and for muscle recovery in Labrador retrievers
Authors: Varney Jessica L. , Fowler J. W. , Gilbert W. C. , Coon C. N.
Published: April 2017

The primary goal was to investigate the effects ofl-carnitine on fuel efficiency, as an antioxidant, and for muscle recovery in Labrador retrievers. Dogs were split into two groups, with one group being supplemented with 250 mg/d of Carniking™l-carnitine powder. Two experiments (Expt 1 and Expt 2) were performed over a 2-year period which included running programmes, activity monitoring, body composition scans and evaluation of recovery using biomarkers. Each experiment differed slightly in dog number and design: fifty-sixv. forty dogs; one endurance and two sprint runs per weekv. two endurance runs; and differing blood collection time points. All dogs were fed a low-carnitine diet in which a fixed amount was offered based on maintaining the minimum starting weight. Results from Expt 1 found that the carnitine dogs produced approximately 4000 more activity points per km compared with the control group during sprint (P = 0·052) and endurance runs (P = 0·0001). Male carnitine dogs produced half the creatine phosphokinase (CPK) following exercise compared with male control dogs (P = 0·05). Carnitine dogs had lower myoglobin at 6·69 ng/ml following intensive exercise compared with controls at 24·02 ng/ml (P = 0·0295). Total antioxidant capacity (TAC) and thiobarbituric acid reactive substance (TBARS) results were not considered significant. In Expt 2, body composition scans indicated that the carnitine group gained more total tissue mass while controls lost tissue mass (P = 0·0006) and also gained lean mass while the control group lost lean mass (P < 0·0001). Carnitine dogs had lower CPK secretion at 23·06v. control at 28·37 mU/ml 24 h after post-run (P = 0·003). Myoglobin levels were lower in carnitinev. control dogs both 1 h post-run (P = 0·0157; 23·83v. 37·91 ng/ml) and 24 h post-run (P = 0·0189; 6·25v.13·5 ng/ml). TAC indicated more antioxidant activity in carnitine dogs at 0·16 mmv. control at 0·13 mm(P = 0·0496). TBARS were also significantly lower in carnitine dogs both pre-run (P = 0·0013; 15·36v. 23·42 µm) and 1 h post-run (P = 0·056; 16·45v. 20·65 µm). Supplementingl-carnitine in the form of Carniking™ had positive benefits in Labrador retrievers for activity intensity, body composition, muscle recovery and oxidative capacity.
Formononetin, an isoflavone, activates AMP-activated protein kinase/β-catenin signalling to inhibit adipogenesis and rescues C57BL/6 mice from high-fat diet-induced obesity and bone loss
Authors: Gautam Jyoti , Khedgikar Vikram , Kushwaha Priyanka , Choudhary Dharmendra , Nagar Geet Kumar , Dev Kapil , Dixit Preety , Singh Divya , Maurya Rakesh , Trivedi Ritu
Published: April 2017

Balance between adipocyte and osteoblast differentiation is the key link of disease progression in obesity and osteoporosis. We have previously reported that formononetin (FNT), an isoflavone extracted fromButea monosperma, stimulates osteoblast formation and protects against postmenopausal bone loss. The inverse relationship between osteoblasts and adipocytes prompted us to analyse the effect of FNT on adipogenesis andin vivobone loss, triggered by high-fat diet (HFD)-induced obesity. The anti-obesity effect and mechanism of action of FNT was determined in 3T3-L1 cells and HFD-induced obese male mice. Our findings show that FNT suppresses the adipogenic differentiation of 3T3-L1 fibroblasts, through down-regulation of key adipogenic markers such as PPARγ, CCAAT/enhancer-binding protein alpha (C/EBPα) and sterol regulatory element-binding protein (SREBP) and inhibits intracellular TAG accumulation. Increased intracellular reactive oxygen species levels and AMP-activated protein kinase (AMPK) activation accompanied by stabilisation ofβ-catenin were attributed to the anti-adipogenic action of FNT.In vivo, 12 weeks of FNT treatment inhibited the development of obesity in mice by attenuating HFD-induced body weight gain and visceral fat accumulation. The anti-obesity effect of FNT results from increased energy expenditure. FNT also protects against HFD-induced dyslipidaemia and rescues deterioration of trabecular bone volume by increasing bone formation and decreasing bone resorbtion caused by HFD. FNT’s rescuing action against obesity-induced osteoporosis commenced at the level of progenitors, as bone marrow progenitor cells, obtained from the HFD mice group supplemented with FNT, showed increased osteogenic and decreased adipogenic potentials. Our findings suggest that FNT inhibits adipogenesis through AMPK/β-catenin signal transduction pathways and protects against HFD-induced obesity and bone loss.
ACCESSORY LIABILITY: PERSISTING IN ERROR
Authors: Krebs Beatrice
Published: April 2017

IN Miller v The Queen [2016] HCA 30, the High Court of Australia (HCA) declined to follow the Privy Council and UK Supreme Court (UKSC) in abolishing the doctrine of extended joint criminal enterprise, as PAL is known in South Australia. Under the Australian doctrine, liability for murder is imposed where an individual “is a party to an agreement to commit a crime and foresees that death or really serious bodily injury might be occasioned by a co-venturer acting with murderous intention and he or she, with that awareness, continues to participate in the agreed criminal enterprise” (at [1]). This reflects the very position that was abandoned in Jogee [2016] UKSC 8; [2016] 2 W.L.R. 681 Ruddock v The Queen UKPC 7 as a “wrong turn” of the English common law.