bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure S7 from Randomized Placebo-Controlled, Biomarker-Stratified Phase Ib Microbiome Modulation in Melanoma: Impact of Antibiotic Preconditioning on Microbiome and Immunity
Authors: Glitza Isabella C. , Seo Yongwoo David , Spencer Christine N. , Wortman Jennifer R. , Burton Elizabeth M. , Alayli Farah A. , Loo Christopher P. , Gautam Shikha , Damania Ashish , Densmore Julie , Fairchild Justin , Cabanski Christopher R. , Wong Matthew C. , Peterson Christine B. , Weiner Brian , Hicks Nathan , Aunins John , McChalicher Christopher , Walsh Emily , Tetzlaff Michael T. , Hamid Omid , Ott Patrick A. , Boland Genevieve M. , Sullivan Ryan J. , Grossmann Kenneth F. , Ajami Nadim J. , LaVallee Theresa , Henn Matthew R. , Tawbi Hussein A. , Wargo Jennifer A.
Published: July 2024

Taxonomic differences from baseline between treatment arms at after antibiotic preconditioning and at C1D1
Supplementary Figure S20 from Randomized Placebo-Controlled, Biomarker-Stratified Phase Ib Microbiome Modulation in Melanoma: Impact of Antibiotic Preconditioning on Microbiome and Immunity
Authors: Glitza Isabella C. , Seo Yongwoo David , Spencer Christine N. , Wortman Jennifer R. , Burton Elizabeth M. , Alayli Farah A. , Loo Christopher P. , Gautam Shikha , Damania Ashish , Densmore Julie , Fairchild Justin , Cabanski Christopher R. , Wong Matthew C. , Peterson Christine B. , Weiner Brian , Hicks Nathan , Aunins John , McChalicher Christopher , Walsh Emily , Tetzlaff Michael T. , Hamid Omid , Ott Patrick A. , Boland Genevieve M. , Sullivan Ryan J. , Grossmann Kenneth F. , Ajami Nadim J. , LaVallee Theresa , Henn Matthew R. , Tawbi Hussein A. , Wargo Jennifer A.
Published: July 2024

Best objective response by baseline Ruminococcaceae abundance levels
Supplementary Figure S18 from Randomized Placebo-Controlled, Biomarker-Stratified Phase Ib Microbiome Modulation in Melanoma: Impact of Antibiotic Preconditioning on Microbiome and Immunity
Authors: Glitza Isabella C. , Seo Yongwoo David , Spencer Christine N. , Wortman Jennifer R. , Burton Elizabeth M. , Alayli Farah A. , Loo Christopher P. , Gautam Shikha , Damania Ashish , Densmore Julie , Fairchild Justin , Cabanski Christopher R. , Wong Matthew C. , Peterson Christine B. , Weiner Brian , Hicks Nathan , Aunins John , McChalicher Christopher , Walsh Emily , Tetzlaff Michael T. , Hamid Omid , Ott Patrick A. , Boland Genevieve M. , Sullivan Ryan J. , Grossmann Kenneth F. , Ajami Nadim J. , LaVallee Theresa , Henn Matthew R. , Tawbi Hussein A. , Wargo Jennifer A.
Published: July 2024

Longitudinal serum proteomics analysis
Supplementary Figure S12 from Randomized Placebo-Controlled, Biomarker-Stratified Phase Ib Microbiome Modulation in Melanoma: Impact of Antibiotic Preconditioning on Microbiome and Immunity
Authors: Glitza Isabella C. , Seo Yongwoo David , Spencer Christine N. , Wortman Jennifer R. , Burton Elizabeth M. , Alayli Farah A. , Loo Christopher P. , Gautam Shikha , Damania Ashish , Densmore Julie , Fairchild Justin , Cabanski Christopher R. , Wong Matthew C. , Peterson Christine B. , Weiner Brian , Hicks Nathan , Aunins John , McChalicher Christopher , Walsh Emily , Tetzlaff Michael T. , Hamid Omid , Ott Patrick A. , Boland Genevieve M. , Sullivan Ryan J. , Grossmann Kenneth F. , Ajami Nadim J. , LaVallee Theresa , Henn Matthew R. , Tawbi Hussein A. , Wargo Jennifer A.
Published: July 2024

Longitudinal taxonomic abundance of Ruminococcaceae species
Supplementary Table S1 from Efficacy and Safety of Adagrasib plus Cetuximab in Patients with KRASG12C-Mutated Metastatic Colorectal Cancer
Authors: Yaeger Rona , Uboha Nataliya V. , Pelster Meredith S. , Bekaii-Saab Tanios S. , Barve Minal , Saltzman Joel , Sabari Joshua K. , Peguero Julio A. , Paulson Andrew Scott , Jänne Pasi A. , Cruz-Correa Marcia , Anderes Kenna , Velastegui Karen , Yan Xiaohong , Der-Torossian Hirak , Klempner Samuel J. , Kopetz Scott E.
Published: July 2024

Table S1. Representativeness of study participants.
Supplementary Figure S1 from Efficacy and Safety of Adagrasib plus Cetuximab in Patients with KRASG12C-Mutated Metastatic Colorectal Cancer
Authors: Yaeger Rona , Uboha Nataliya V. , Pelster Meredith S. , Bekaii-Saab Tanios S. , Barve Minal , Saltzman Joel , Sabari Joshua K. , Peguero Julio A. , Paulson Andrew Scott , Jänne Pasi A. , Cruz-Correa Marcia , Anderes Kenna , Velastegui Karen , Yan Xiaohong , Der-Torossian Hirak , Klempner Samuel J. , Kopetz Scott E.
Published: July 2024

Supplementary Figure S1. Changes from baseline in sum of target lesion diameters over time for patients continuing treatment after progression, either with adagrasib plus cetuximab (n = 38), adagrasib only (n = 10), or cetuximab only (n = 1). Only patients with available post-progression scans are included in the plot (n = 33 for adagrasib plus cetuximab; n = 1 for adagrasib only).
Data from Randomized Placebo-Controlled, Biomarker-Stratified Phase Ib Microbiome Modulation in Melanoma: Impact of Antibiotic Preconditioning on Microbiome and Immunity
Authors: Glitza Isabella C. , Seo Yongwoo David , Spencer Christine N. , Wortman Jennifer R. , Burton Elizabeth M. , Alayli Farah A. , Loo Christopher P. , Gautam Shikha , Damania Ashish , Densmore Julie , Fairchild Justin , Cabanski Christopher R. , Wong Matthew C. , Peterson Christine B. , Weiner Brian , Hicks Nathan , Aunins John , McChalicher Christopher , Walsh Emily , Tetzlaff Michael T. , Hamid Omid , Ott Patrick A. , Boland Genevieve M. , Sullivan Ryan J. , Grossmann Kenneth F. , Ajami Nadim J. , LaVallee Theresa , Henn Matthew R. , Tawbi Hussein A. , Wargo Jennifer A.
Published: July 2024

Abstract
Gut-microbiota modulation shows promise in improving immune-checkpoint blockade (ICB) response; however, precision biomarker-driven, placebo-controlled trials are lacking. We performed a multicenter, randomized placebo-controlled, biomarker-stratified phase I trial in patients with ICB-naïve metastatic melanoma using SER-401, an orally delivered Firmicutesenriched spore formulation. Fecal microbiota signatures were characterized at baseline; patients were stratified by high versus low Ruminococcaceae abundance prior to randomization to the SER-401 arm (oral vancomycin-preconditioning/SER-401 alone/nivolumab + SER-401), versus the placebo arm [placebo antibiotic/placebo microbiome modulation (PMM)/nivolumab + PMM (NCT03817125)]. Analysis of 14 accrued patients demonstrated that treatment with SER-401 + nivolumab was safe, with an overall response rate of 25% in the SER-401 arm and 67% in the placebo arm (though the study was underpowered related to poor accrual during the COVID-19 pandemic). Translational analyses demonstrated that vancomycin preconditioning was associated with the disruption of the gut microbiota and impaired immunity, with incomplete recovery at ICB administration (particularly in patients with high baseline Ruminococcaceae). These results have important implications for future microbiome modulation trials.

Significance: This first-of-its-kind, placebo-controlled, randomized biomarker-driven microbiome modulation trial demonstrated that vancomycin + SER-401 and anti–PD-1 are safe in melanoma patients. Although limited by poor accrual during the pandemic, important insights were gained via translational analyses, suggesting that antibiotic preconditioning and interventional drug dosing regimens should be carefully considered when designing such trials.

See author Yongwoo David Seo discuss this research brief, published simultaneously at the AACR Annual Meeting 2024: https://vimeo.com/932607668/63addff7fc
Data from The Pan-RAF–MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS–MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers
Authors: Ryan Meagan B. , Quade Bradley , Schenk Natasha , Fang Zhong , Zingg Marshall , Cohen Steven E. , Swalm Brooke M. , Li Chun , Özen Ayşegül , Ye Chaoyang , Ritorto Maria Stella , Huang Xin , Dar Arvin C. , Han Yongxin , Hoeflich Klaus P. , Hale Michael , Hagel Margit
Published: July 2024

Abstract
Alterations in the RAS–MAPK signaling cascade are common across multiple solid tumor types and are a driver for many cancers. NST-628 is a potent pan-RAF–MEK molecular glue that prevents the phosphorylation and activation of MEK by RAF, overcoming the limitations of traditional RAS–MAPK inhibitors and leading to deep durable inhibition of the pathway. Cellular, biochemical, and structural analyses of RAF–MEK complexes show that NST-628 engages all isoforms of RAF and prevents the formation of BRAF–CRAF heterodimers, a differentiated mechanism from all current RAF inhibitors. With a potent and durable inhibition of the RAF–MEK signaling complex as well as high intrinsic permeability into the brain, NST-628 demonstrates broad efficacy in cellular and patient-derived tumor models harboring diverse MAPK pathway alterations, including orthotopic intracranial models. Given its functional and pharmacokinetic mechanisms that are differentiated from previous therapies, NST-628 is positioned to make an impact clinically in areas of unmet patient need.

Significance: This study introduces NST-628, a molecular glue having differentiated mechanism and drug-like properties. NST-628 treatment leads to broad efficacy with high tolerability and central nervous system activity across multiple RAS- and RAF-driven tumor models. NST-628 has the potential to provide transformative clinical benefits as both monotherapy and vertical combination anchor.

See first author Meagan B. Ryan discuss this research article, published simultaneously at the AACR Annual Meeting 2024: https://vimeo.com/932606757/4d0bd5aa98
Supplementary Figure S3 from Inhibition of Notch4 Using Novel Neutralizing Antibodies Reduces Tumor Growth in Murine Cancer Models by Targeting the Tumor Endothelium
Authors: Eng Jason W.-L. , Kato Yu , Adachi Yusuke , Swaminathan Bhairavi , Naiche L.A. , Vadakath Rahul , Sakamoto Yoshimasa , Nakazawa Youya , Tachino Sho , Ito Ken , Abe Takanori , Minoshima Yukinori , Hoshino-Negishi Kana , Ogasawara Hideaki , Kawakatsu Tomomi , Nishimura Miyuki , Katayama Masahiko , Shimizu Masashi , Tahara Kazuhiro , Sato Toshitaka , Suzuki Katsuhisa , Agarwala Kishan , Iwata Masao , Nomoto Kenichi , Ozawa Yoichi , Imai Toshio , Funahashi Yasuhiro , Matsui Junji , Kitajewski Jan
Published: July 2024

A, Schematic of experimental design of Py8119 orthotopically implanted tumors in RiboTagEC mice. Female RiboTagEC mice with 75mg/kg of tamoxifen (20mg/mL) for 5 days by IP injection. Py8119 tumors were implanted at 8 weeks of age and then treated once tumors reached 50mm3 with twice weekly IV control IgG or 6-3-A6 for a total of 10 days (n=3). B, Growth curve of RiboTagEC treated with 25mg/kg of IV control IgG or 6-3-A6 twice weekly for 10 days (n=3). C, Heatmap of endothelial expressed genes segregated by total mRNA input and ribosomal IP mRNA from control IgG treated and 6-3-A6 treated Py8119 tumors. D, PCA plots of the ribosomal IP fraction from control IgG and 6-3-A6 treated tumors. Two samples from the control IgG and 6-3-A6 groups were identified as outliers and removed from analysis. E, Heatmap of downstream Notch regulated genes from endothelial IP of the control IgG or 6-3-A6 treated tumors and quantitative rt-PCR of the canonical Notch target gene Hes1 and Rnd1 amplified from 6-3-A6 treated and control RiboTag IP fractions (n=4). F, Heatmaps of genes associated with significantly enriched or downregulated signaling pathways involved in inflammation and extracellular matrix interactions. All heatmap data presented as Z-scores. Statistics by t-test for qPCR studies
Supplementary Figure S2 from Inhibition of Notch4 Using Novel Neutralizing Antibodies Reduces Tumor Growth in Murine Cancer Models by Targeting the Tumor Endothelium
Authors: Eng Jason W.-L. , Kato Yu , Adachi Yusuke , Swaminathan Bhairavi , Naiche L.A. , Vadakath Rahul , Sakamoto Yoshimasa , Nakazawa Youya , Tachino Sho , Ito Ken , Abe Takanori , Minoshima Yukinori , Hoshino-Negishi Kana , Ogasawara Hideaki , Kawakatsu Tomomi , Nishimura Miyuki , Katayama Masahiko , Shimizu Masashi , Tahara Kazuhiro , Sato Toshitaka , Suzuki Katsuhisa , Agarwala Kishan , Iwata Masao , Nomoto Kenichi , Ozawa Yoichi , Imai Toshio , Funahashi Yasuhiro , Matsui Junji , Kitajewski Jan
Published: July 2024

A-C, Weights of Balb/c nude mice implanted with Calu-6, SEKI and DU145 xenografts (n=5 for all tumor models) and treated with control IgG (all), 6-3-A6 (all), bevacizumab (SEKI), lenvatinib (SEKI), or paclitaxel (DU145). D, Mass of non-tumor bearing C57BL/6 mice treated IV with E7011 or control IgG twice weekly for 4 weeks (n=5). E, Representative images of the livers. Insets show 2x magnified view of the vessels at the periphery of the liver lobe. Scale bar = 6cm. F, Final tumor mass of orthotopically implanted Py8119 tumors treated IV with E7011 (25mg/kg) starting 12 hours after initial implantation (n=13 control IgG, n=12 E7011). Growth curve statistics performed with 2-way Anova, plotted as average ± SEM. Statistics by t-test, plotted as average ± SEM; *p<0.05.
Figure 4 from Inhibition of Notch4 Using Novel Neutralizing Antibodies Reduces Tumor Growth in Murine Cancer Models by Targeting the Tumor Endothelium
Authors: Eng Jason W.-L. , Kato Yu , Adachi Yusuke , Swaminathan Bhairavi , Naiche L.A. , Vadakath Rahul , Sakamoto Yoshimasa , Nakazawa Youya , Tachino Sho , Ito Ken , Abe Takanori , Minoshima Yukinori , Hoshino-Negishi Kana , Ogasawara Hideaki , Kawakatsu Tomomi , Nishimura Miyuki , Katayama Masahiko , Shimizu Masashi , Tahara Kazuhiro , Sato Toshitaka , Suzuki Katsuhisa , Agarwala Kishan , Iwata Masao , Nomoto Kenichi , Ozawa Yoichi , Imai Toshio , Funahashi Yasuhiro , Matsui Junji , Kitajewski Jan
Published: July 2024

Treatment of tumors with 6-3-A6/E7011 delays tumor growth in syngeneic tumor models which express endothelial Notch4. A, IF staining of murine Lewis lung carcinoma, murine Py8119 breast carcinoma, and murine B16F10 melanoma with Notch4 and CD31. Arrowheads indicate Notch4-expressing vessels (scale bar = 200 μm). B and C, Preventative strategy using Py8119 tumor cells orthotopically implanted into the mammary fat pad and treated with B, E7011 (n = 18 human IgG, n = 17 E7011) or C, 6-3-A6 (n = 4) twice weekly starting 12 hours following tumor implantation. D and F, Tumor growth curve of subcutaneously implanted D, Lewis lung (n = 4) and E, B16F10 (n = 7) treated intravenously with E7011 (25 mg/kg twice weekly) and orthotopically implanted F, Py8119 murine breast carcinomas (n = 5) treated intravenously with 6-3-A6 (25 mg/kg twice weekly) once the average tumor volume of each cohort had reached approximately 30 mm3. Statistical analysis performed with two-way ANOVA for tumor growth curves, plotted as average ± SEM; *, P < 0.05; ***, P < 0.001. TNBC, triple-negative breast cancer.
Ruthenium-106 Plaque Brachytherapy for Circumscribed Choroidal Hemangioma: A Case Series and Review of Literature
Authors: Swaify Islam Y. , Hamza Hany , Khattab Ayman M. , El-Agha Mohamed-Sameh H. , El-Helw Mostafa A. , Macky Tamer A. , Hassanein Dina H. , Salah Shaymaa H. , Abdullatif Abdussalam M. , Noureldine Alia M. , Meqdad Yasmine A. , Al-Etr Salma F. , El Qadi Layla , Fayed Alaa E.
Published: July 2024

Introduction: We aim to report the anatomical and functional outcomes of ruthenium-106 brachytherapy in the management of circumscribed choroidal hemangiomas (CCH). Methods: This is a single-center, retrospective case series including patients with unilateral symptomatic CCH treated with ruthenium-106 brachytherapy at the Cairo University Ocular Oncology Service. Patient records were analyzed for patients’ demographics, best corrected visual acuity (BCVA), tumor dimensions (thickness and largest base diameter), foveal subretinal fluid, radiation-related complications, and recurrence. Results: Seven patients were included in the study (including 6 males) with a mean age of 39.3 ± 15.4 years; ruthenium-106 plaque was used to deliver 50 Gray to the tumor apex. After a mean follow-up duration of 12.5 months, all patients had significant improvement in BCVA after treatment, mean tumor height decreased significantly from 4.76 ± 1.76 mm to 1.70 ± 1.2 mm (p value 0.01). The largest tumor base diameter also decreased significantly from 9.13 ± 2.68 mm to 4.65 ± 3.75 mm (p value 0.05). Subretinal fluid and exudative retinal detachment resolved in all patients, and no significant radiation-related complications were observed in any patient. None of the patients needed any further treatment or experienced recurrence within the follow-up period. Conclusion: Ruthenium-106 brachytherapy is an effective tool in the management of symptomatic CCH with a good visual prognosis and safety profile.
Outcomes of Cardiac Resynchronization Therapy by New York Heart Association Class: A Patient‐Level Meta‐Analysis
Authors: Shivakumar Nishkala , Friedman Daniel J. , Fudim Marat , Abraham William T. , Cleland John G. F. , Curtis Anne B. , Gold Michael R. , Kutyifa Valentina , Linde Cecilia , Young James , Tang Anthony , Olivas‐Martinez Antonio , Inoue Lurdes Y.T. , Sanders Gillian D. , Al‐Khatib Sana M.
Published: July 2024

Background

Data on the benefits of cardiac resynchronization therapy (CRT) in patients with severe heart failure symptoms are limited. We investigated the relative effects of CRT in patients with ambulatory New York Heart Association (NYHA) IV versus III functional class at the time of device implantation.

Methods and Results

In this meta‐analysis, we pooled patient‐level data from the MIRACLE (Multicenter InSync Randomized Clinical Evaluation), MIRACLE‐ICD (Multicenter InSync Implantable Cardioversion Defibrillation Randomized Clinical Evaluation), and COMPANION (Comparison of Medical Therapy, Pacing, and Defibrillation in Heart Failure) trials. Outcomes evaluated were time to the composite end point of the first heart failure hospitalization or all‐cause mortality, and time to all‐cause mortality alone. The association between CRT and outcomes was evaluated using a Bayesian hierarchical Weibull survival regression model. We assessed if this association differed between NYHA III and IV groups by adding an interaction term between CRT and NYHA class as a random effect. A sensitivity analysis was performed by including data from RAFT (Resynchronization‐Defibrillation for Ambulatory Heart Failure). Our pooled analysis included 2309 patients. Overall, CRT was associated with a longer time to heart failure hospitalization or all‐cause mortality (adjusted hazard ratio [aHR], 0.79 [95% credible interval [CI], 0.64–0.99]; posterior probability or
P
=0.044), with a similar association with time to all‐cause mortality (aHR, 0.78 [95% CI, 0.59–1.03];
P
=0.083). Associations of CRT with outcomes were not significantly different for those in NYHA III and IV classes (ratio of aHR, 0.72 [95% CI, 0.30–1.27];
P
=0.23 for heart failure hospitalization/mortality; ratio of aHR, 0.70 [95% CI, 0.35–1.34];
P
=0.27 for all‐cause mortality alone). The sensitivity analysis, including RAFT data, did not show a significant relative CRT benefit between NYHA III and IV classes.

Conclusions

Overall, there was no significant difference in the association of CRT with either outcome for patients in NYHA functional class III compared with functional class IV.
Validation of the NULL‐EASE Score for Predicting Survival in a Multiethnic Asian Cohort of Out‐of‐Hospital Cardiac Arrest
Authors: Lim Shir Lynn , Chan Siew Pang , Shahidah Nur , Woo Kai Lee , Lam Sean Shao Wei , Leong Benjamin Sieu‐Hon , Lip Gregory Y. H. , Ong Marcus Eng Hock , Chia Michael Y. C. , Ng Yih Yng , Gan Han Nee , Tiah Ling , Ng Wei Ming , Tay Wei Ling , Cheah Si Oon , Mao Desmond R. , Edwin Nausheen , Low Shun Yee
Published: July 2024

Background

NULL‐PLEASE is a simple and accurate clinical scoring system developed in a Western cohort of patients with out‐of‐hospital cardiac arrest (OHCA). The need for blood test results limits its use in early stages of care. We adapted and validated the NULL‐EASE score (without laboratory tests) in an independent, multiethnic Asian cohort of patients with out‐of‐hospital cardiac arrest.

Methods and Results

Using the Singapore OHCA registry, we included consecutive adult patients with out‐of‐hospital cardiac arrest who survived to hospital admission between April 2010 to December 2020. In‐hospital mortality was the primary outcome. Logistic regression analyses were performed with STATA MP v18. Of 3274 patients (median age 64, interquartile range 54–75; 67.9% male) included in the study, 2476 (75.6%) had in‐hospital mortality. NULL‐EASE score was significantly lower in survivors compared with nonsurvivors (median [inter quartile range] 3 [1–4] versus 6 [4–7];
P
<0.001) and strongly predictive of mortality (area under receiver operating characteristic, 0.81 [95% CI, 0.79–0.83]). Patients with a score of ≥3 had higher odds of mortality (adjusted odds ratio, 8.11 [95% CI, 6.57–10.00]) when compared with those with lower scores, after adjusting for sex, residential arrest, diabetes, respiratory disease, and stroke. A cutoff value of ≥3 predicted mortality with 92.2% sensitivity, 84.1% positive predictive value, 46.1% specificity, and 65.5% negative predictive value. NULL‐EASE score performed better in younger compared with older patients (area under receiver operating characteristic, 0.82 versus 0.77,
P
=0.008).

Conclusions

The NULL‐EASE score has good discriminative performance (sensitivity and accuracy) in our multiethnic Asian cohort, but the cutoff of ≥3 falls short of the desired level of specificity for therapeutic decision‐making.
Effect of a Cardiovascular Polypill on Poststroke Cognition Among Ghanaians: Secondary Analysis of a Randomized Clinical Trial
Authors: Sarfo Fred Stephen , Adu‐Gyamfi Rexford , Opare‐Addo Priscilla Abrafi , Agyei Benedict , Ampofo Michael , Nguah Samuel Blay , Ovbiagele Bruce
Published: July 2024

Background

Poststroke cognitive impairment is prevalent worldwide, with no satisfactory preventative therapeutic strategies. We report on the effect of a cardiovascular polypill on cognitive performance among recent stroke survivors.

Methods and Results

The SMAART (Stroke Minimization through Additive Anti‐atherosclerotic Agents in Routine Treatment) trial was a phase II randomized trial primarily assessing the polypill versus usual care for secondary prevention after a recent ischemic stroke. Participants allocated to the experimental arm were provided 2 Polycaps taken orally once a day for 12 months. A capsule of Polycap contained aspirin 100 mg, simvastatin 20 mg, hydrochlorothiazide 12.5 mg, ramipril 5 mg, and atenolol 50 mg. Participants in the usual care arm received standard secondary prevention therapy. We compared slopes of the trajectory of raw scores in the executive, language, memory, and visuospatial cognitive domains and aggregated cognitive scores over 12 months via a linear mixed‐effects model. We enrolled 148 eligible participants (n=74 in each arm) and 59 versus 64 participants in the polypill and usual care arms, respectively, at month 12. Compared with the usual care arm, the slopes of cognitive performance over 12 months in the polypill arm were steeper by 2.02 units (95% CI, 0.52–3.53),
P
=0.009 in executive domain, 1.88 units (95% CI, 0.42–3.34),
P
=0.012 in language domain, 2.60 (0.03–5.17),
P
=0.049 in memory domain, 0.55 (−0.80 to 1.91),
P
=0.42 in the visuospatial domain, and global cognitive performance 6.87 units (95% CI, 1.44–12.30),
P
=0.013.

Conclusions

The cardiovascular polypill is associated with a signal of better cognitive performance over 12 months among stroke survivors. Further definitive trials are warranted.

Registration

URL:
https://www.clinicaltrials.gov
; Unique Identifier: NCT03329599.
Personalized Video‐Based Educational Platform to Improve Stroke Knowledge: A Randomized Clinical Trial
Authors: Favilla Christopher G. , Reehal Navpreet , Cummings Stephanie R. , Burdett Rebecca , Stein Laura A. , Shakibajahromi Banafsheh , Yuan Kristy , Sloane Kelly L. , Kasner Scott E.
Published: July 2024

Background

Stroke knowledge is critical to treatment adherence and poststroke outcomes. Here, we aimed to quantify the impact of a personalized video‐based educational platform to test the hypothesis that it improves patient satisfaction and stroke knowledge.

Methods and Results

In a single‐center pilot randomized trial, all patients with stroke and caregivers received standard stroke education during the hospitalization, but half were randomized to receive access to MyStroke, a personalized educational platform that provided brief videos about their stroke, risk factors, medications, and poststroke lifestyle. Satisfaction, stroke knowledge, and quality of life were assessed 7, 30, and 90 days after discharge. A total of 120 subjects (96 patients and 24 caregivers) were randomized to standard education (n=59) or MyStroke. At 90 days post‐stroke, those who received MyStroke were more likely to be satisfied with the stroke education the received (90% versus 73%,
P
=0.05) and more likely to correctly identify their stroke cause (67% versus 32%,
P
=0.003). However, MyStroke was not associated with a difference in self‐reported quality of life (EuroQol Visual Analogue Scale: 80 versus 75,
P
=0.06) or general stroke knowledge (total Stroke Patient Education Retention: 5 versus 5,
P
=0.47). With respect to secondary end points, MyStroke increased risk factor awareness 7 and 30 days poststroke, but this difference was not significant at 90 days.

Conclusions

The MyStroke personalized video‐based education platform improved patient and caregiver satisfaction while improving some aspects of personalized stroke knowledge without improving general stroke knowledge. A multicenter trial is needed to confirm these results, clarify generalizability, and target clinically relevant metrics such as stroke recurrence or adherence.

Registration

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT05118503.
Stok Yönetiminde ABC Analizi ve Çok Kriterli Karar Verme: Bir Tekstil Firmasında Uygulama
Authors: Nebati Emine Elif
Published: July 2024

Tedarik zinciri yönetimi giderek önem kazanmaktadır. Rekabet koşullarında firmalar, müşteri beklentilerini karşılama ve maliyetleri düşürme çabasındadır. Bu hedeflere ulaşmanın en önemli araçlarından biri de stok yönetimidir. Rekabet ortamında en önemli maliyet faktörlerinden biri olan envanter maliyetlerinin azaltılarak etkin yönetilmesi kritik bir öneme sahiptir. Stok yönetimi, stoğun ne kadar ve ne zaman sipariş edileceğine karar verilmesini ve stokların önem derecesine göre sınıflandırılmasını hedeflemektedir. Çalışma kapsamında bir tekstil firmasında öncelikle klasik ABC analizi ile stok kalemleri sınıflandırılmıştır. İkinci olarak literatür taraması sonucu belirlenen kriterler AHP yöntemi ile ağırlıklandırılmış ve stok kalemleri CoCoSo yöntemi ile sıralanmıştır. Sonrasında klasik ABC ve çok kriterli ABC analizi sonuçları karşılaştırılmıştır. Sonuç olarak bazı stokların ABC analizi ile değerlendirildiğinde kritik olduğu belirlenmiş olsa da, çok kriterli karar verme (ÇKKV) yöntemleri kullanıldığında bu stokların daha az kritik olduğu saptanmıştır.
İslamofobi Söylemlerinin Yayılmasında Medyanın Rolü: Bibliyometrik Bir Analiz
Authors: Uzun Bünyamin
Published: July 2024

Bir insanın ya da toplumun inançları nedeniyle dışlanması, şüpheyle yaklaşılması ve düşmanca söylem ya da eylemlere maruz kalması insanlık dışı bir yaklaşımdır. İslamofobi, tam da bu çerçevede söylem ve eylemlerin oluştuğu bir olgudur. Özellikle Müslümanların azınlıkta olduğu Batı toplumlarında İslamofobi söylemler ve eylemleri son yıllarda sıkça görülmektedir. İslamofobi söylemlerinin oluşması ve yaygınlaşmasında medya önemli bir role sahiptir. Medyanın geniş kitlelere ulaşması nedeniyle insanların düşüncelerini etkilediği bilinmektedir. Bu anlamda İslamofobi algısının yaratılması ve Müslümanlara karşı olumsuz söylem ve eylemlerin ortaya çıkmasında medya etkili olmaktadır. Bu çalışmada İslamofobi ve medya konusunda yapılan çalışmalardan yola çıkarak İslamofobi’nin yayılımında medyanın konumuna ilişkin genel bir bakış açısı sunulmaktadır. Bu bakımdan çalışmada Web of Science veri tabanında yer alan 465 araştırma makalesi bibliyometrik yöntemle incelenmiştir. Çalışmanın en önemli sonuçları arasında İslamofobi ve medya konusunda en fazla çalışmanın iletişim bilimlerinde (n=109) yapılması yer almaktadır. İslamofobi ve medya konusunda yapılan çalışmalarda çeşitli ülkelerin medyalarında kullanılan İslamofobi söylemlerine odaklanıldığı saptanmıştır.
Sokakta Çalıştırılan Çocukların Sorunları ve İhtiyaçları: Ankara Örneği
Authors: Erdemir Turgut Asiye , Sürsavur Latife
Published: July 2024

Çocukların sokakta çalıştırılması çok sayıda risk faktörünü beraberinde getirmektedir. Sokakta çalıştırılan çocukların yaşadıkları sorunların ve ihtiyaçlarının neler olduğunu öğrenmek amacıyla nitel araştırma tasarımı kullanılarak yapılan bu araştırmada, Ankara ilinde kent merkezinde çalışan 11 çocuk ile yüz yüze görüşmeler gerçekleştirilmiştir. Araştırmacılar tarafından geliştirilen yarı yapılandırılmış görüşme formu aracılığıyla derinlemesine görüşmelerle toplanan veriler MAXQDA 2020 paket programı kullanılarak çözümlenmiştir. Araştırmadan elde edilen sonuçlara göre “sokakta çalıştırılan çocukların sosyodemografik ve aile özellikleri”, “sokakta çalıştırılan çocukların eğitim özellikleri” “sokakta çalıştırılan çocukların yaşadıkları sorunlar”, “sokakta çalıştırılan çocukların ihtiyaçları” gibi dört ana tema belirlenmiştir. Araştırmanın sonucunda sokakta çalıştırılan çocukların büyük bir kısmının ilköğretim çağında erkek çocuklardan oluştuğu, çok kardeşli ailelerden geldikleri, ailelerinin sosyoekonomik düzeylerinin düşük olduğu, çocukların aile ekonomisine destek olmak için sokakta çalıştırıldıkları tespit edilmiştir.
Hydro Political Relation in the Eastern Nile Basin
Authors: Mulugeta Getaye , Asress Degu
Published: July 2024

Hydropolitical relations have long attracted the world of academia, and hydrohegemony and counter-hydrohegemony frameworks have recently become important in analysing power relations between riparian states. However, little attention has been given to the hydrohegemonic situation of the Nile River. This study tries to analyse this status, specifically in the Eastern Nile Basin. The data, elicited through unstructured interviews from purposively selected informants, has been analysed thematically. The findings reveal that Egypt aspires to be a hegemon in the basin but is not. Despite its use of different coercive and subtle mechanisms to induce ideational or hegemonic compliance, these have not been successful: Ethiopia has not consented to or accepted Egypt’s claim over the Nile. Concomitantly, since the 1990s, Ethiopia’s position has transcended from veiled to overt contest, which anticipates a new order, challenging the monopolistic position of Egypt.
Tanks for Nothing: an Explanation of Plautus Casina 121-125
Authors: Barrios-Lech Peter
Published: July 2024

The author uses the literary and material record to explicate the manual labour described in Plautus, Casina 121-125. The original Greek (it is argued) featured a simpler task, evocative of the myth of the Danaids.
A Survey of American Synagogue Stained Glass
Authors: Cooper Alanna E.
Published: July 2024

This article addresses the lacuna of scholarship on Jewish-American stained glass by presenting a historical overview of this prevalent synagogue art form (1845 to the present). Analysis of key trends reveals Jewish congregations’ engagement with Christian influences by imitating the work of church stained glass in some ways while differentiating in other ways. Jewish artists and congregational leaders have also been in conversation with each other, sharing thematic and design ideas to formulate a loosely shared aesthetic and religious approach towards creating windows for their houses of worship. In accordance with the Second Commandment’s prohibition against creating “graven images,” God in figural form does not appear in synagogue space. Instead, a Jewish technique for eliciting a sense of Divine in the sanctuary has included a repertoire of light-filled images—including torches, lamps, fire, and celestial bodies—to convey a spiritual presence, enhanced by actual light from the sun itself as refracted through the windows.
Mûsār in Prov 19:27 and Sir 6:22
Authors: Reymond Eric D.
Published: July 2024

The difficult text of Prov 19:27 can be explained with the help of Sir 6:22, where explicit wordplay with the word מוּסָר suggests that this word was interpreted not only as the noun “instruction” from the root יסר, but also as a hophal participle from the root סור that may be translated “what is remote, obscure, rejected.”
Animals as Intentional Political Agents and God’s Warriors in Sign-Themed Qurʾānic Narratives
Authors: Kanwal Aroosa , Mansoor Asma
Published: July 2024

Taking its cue from the Islamic Ecological Paradigm, deeply rooted in Islamic religious traditions, which emerged more than 1400 years ago, this paper reimagines the human-nonhuman relationship against the backdrop of the arguably assumed superiority of mankind in (Islamic) theological discourses. Using Qurʾānic narratives as a key point of divergence in the natural superiority of man within the idea of vicegerency, we argue that the Qurʾān’s egalitarian ethos presents animals as ‘intentional political agents’ (Pepper 2021: 30) independent of human intercession. This agency enables them to be key players in deciding the outcomes of political conundrums; in so doing, it also rebuts and destabilises arrogant anthropocentric presuppositions associated with the idea of vicegerency. We particularly read, in ‘signs themed’ Qurʾānic narratives, a dynamic relationship between humans and animals through the animal’s role as Allah’s warriors and agents against human oppressors and transgressors. Drawing on the Islamic Ecological Paradigm, Angie Pepper’s idea of intentional political agency and Sarra Tlili’s de-anthropocentric reading of the Qurʾān, we suggest that the Qurʾān robustly invites humans to reflect on the animal world by foregrounding animals as political agents while epitomising human accountability and responsibility towards them instead of establishing a relationship of dominance.
A Disordered Genealogy and a New Family of Greek New Testament Manuscripts
Authors: Patton Andrew J.
Published: July 2024

Greek New Testament manuscripts frequently format the genealogy of Jesus in Luke in multiple columns. This format has led copyists to introduce errors in the sequence of names by reading the text in the wrong direction. This article presents five manuscripts of the Gospels with catenae which transmit a disordered genealogy of Jesus. The analysis of the disruptions to the sequence of Jesus’s ancestors allows the reconstruction of their exemplar. The article further identifies two codices without commentaries attesting the same pattern of disorder. The other codices with this form of Luke 3:23–38 and the contents of the five catena manuscripts substantiate that they have a common archetype and form a new family of Greek New Testament manuscripts.
Acceptability and Purity in Acts 10:35
Authors: Akagi Kai
Published: July 2024

δεκτός in Acts 10:35 may be understood as a term from the Jewish purity and consecration system. With a high degree of consistency, Hebrew רצון and רצה are rendered in cultic contexts in the LXX with words of the δεκ- lexeme. While verbs of the δεκ- lexeme are not uncommon prior to the LXX, adjectives of the δεκ-lexeme are uncommon outside of the LXX prior to the NT, establishing the use of δεκ- adjectives in the LXX as the primary context for δεκτός in Acts. This interpretation is consistent with themes of purity and consecration in the Cornelius episode and throughout Luke-Acts.
“When Jobs Are Scarce”
Authors: Korotayev Andrey , Meshcherina Kira , Ustyuzhanin Vadim
Published: July 2024

This study examines the influence of Islam on attitudes toward female labor force participation as reflected in responses to the World Values Survey (WVS) question: “When jobs are scarce, should men have more right to a job than women?”. The authors expect that respondents in Islamic (Muslim-majority) countries will have more positive attitudes toward this statement than respondents in non-Islamic countries. They test the hypothesis that the higher the percentage of Muslims in a given country, the more likely respondents are to agree with this statement. The correlation is in the predicted direction, statistically significant and quite strong. Meanwhile, tests show that respondents in Arab countries show particularly strong support for this statement (significantly stronger than in non-Arab Muslim-majority countries). Based on this, the authors try to discuss possible determinants of such attitudes. Particular support is observed in Arab countries and those non-Arab countries that have experienced a strong Arab influence. These countries can be identified with the Umayyad Caliphate in the past and may have been particularly influenced by non-Islamic elements of Arab culture that are not directly related to Islam.
A Philosophical Reading of Justice and Its Resistance to Social Change among the Igbo of Nigeria
Authors: Anizoba Emmanuel C.
Published: July 2024

This article explores justice among the Igbo of Nigeria through a philosophical lens. Its discussion focuses on how the Igbo idea of justice intermingles with the idea of akadiocha (clean hands), proverbs, names and equal treatment for all, including the ancestors. Personal interviews form the primary sources of data collection while library materials are the secondary sources. The economy of the Igbo people of Nigeria is dynamic and multifaceted, with traditions of commerce, agriculture, manufacturing, and diaspora contributions playing crucial roles in its development and growth. The Igbo concept of “offor” embodies enduring traditions, values, and social structures that resist rapid social change. Its symbolism and significance continue to shape various aspects of Igbo culture, reinforcing a sense of identity and continuity amidst evolving social, economic, and political dynamics. Western justice is a multifaceted philosophical idea that reflects a commitment to fairness, equality, and the rule of law within legal systems influenced by Western philosophical traditions. By examining these differences, we gain insight into the multifaceted understanding of justice within Igbo culture, which encompasses spiritual, ancestral, and communal dimensions beyond Western paradigms.
Does Behavioral Decision Theory Influence the Adoption of Mobile Banking among Customers? Experience from Tanzania
Authors: John Yuslida
Published: July 2024

Though the benefits of mobile adoption in banking institutions are extensively recognized, there is a low pace of its adoption among customers. The establishment of behavioral factors that can motivate banking customers to adopt mobile banking has been a concern. Provided that no single framework can fit all sizes, this study builds on past research to invest in behavioral factors among customers toward MB adoption. Through a cross-sectional survey design, 325 questionnaires were distributed among university students in Tanzania to assess customer behavior that can motivate MB adoption. Using structural equation modeling (AMOS 21), the study found that when customers possess judgmental heuristic knowledge that allows them to understand how risks associated with the adoption of MB can be resolved, they are motivated to adopt the innovation. The study recommends the importance of providing knowledge to their customers through various mechanisms and the benefits associated with mobile banking adoption.
Analysis of Digitalization and Sustainable Development in Africa
Authors: Hlali Arbia , Gafsi Nesrine
Published: July 2024

Many countries in the world competed to integrate technology in all sectors, and some of them were able to achieve the Sustainable Development Goals in this area. However, African countries face several challenges in the field of digitalization. This article aims to study the results of these difficulties that appeared clearly during the COVID-19 crisis. The study used a SWOT analysis to highlight the status of the digital transformation in Africa. The results recommend that the countries need to integrate the digital innovation into the systems of work, education, healthcare, and environment. Also, it proved that these challenges, especially those related to the digital integration, represents a great obstacle to achieve the goals of sustainable development.
Why the Brazilian Jewish Left Is Not Anti-Zionist
Authors: Huberman Bruno
Published: July 2024

This paper explores the praxis of the Zionist Left in Brazil, particularly during the 2010s. It argues that the Zionist Left, which claims to be a progressive grouping that stands in solidarity with the oppressed people in Palestine and in Brazil, functions in fact as a colonial counterrevolutionary actor against radical-left emancipatory politics. Indeed, the Zionist Left functions as a gatekeeper, blocking sectors of the Jewish community and the Brazilian Left from joining the growing anti-Zionist decolonial movement in Brazil. This paper aims to show how various Zionist Left groups have historically worked with the Zionist elite and the Brazilian state to undermine anti-Zionist communist Jewish alternatives by resorting to fraudulent discourse and even force in order to build support for the Zionist settler-colonial project in Palestine. This paper utilises a Marxist, anti-Zionist and anti-colonial framework in order to provide a counter-hegemonic critique for an emancipatory praxis that rejects colonialism.
Rational Thinking and Value Reconstruction of School Reform: Based on the Historical Evolution of China’s Macroscopic Educational Goals
Authors: Wang Qiong
Published: July 2024

This paper discusses the historical evolution of Chinese school reform, focusing on the important roles of rational thinking and value reconstruction in the process of reform. Through the review of the historical process of school reform in China, the important milestones of the past reform are determined, which provides the historical background for understanding the reform. This paper analyzes the application of rational thinking in school reform and emphasizes the necessity of accurately identifying and solving difficulties in the process of reform. At the same time, it emphasizes the key role of value reconstruction in the realization of an effective reform and provides a theoretical framework and practical direction. At the macro level, the paper examines the historical evolution of China’s educational goals and analyzes the impact of these changes on school reform. Through the historical perspective, this paper reveals the historical enlightenment in the reform, discusses the intersection of history and value reconstruction, and puts forward the school reform strategy based on the historical perspective. The paper looks forward to the future of school reform based on historical evolution and points out the upcoming challenges and possible directions of reform. In summary, the main proposition of this paper is to effectively promote school reform through rational thinking and value reconstruction, combined with historical perspective. The core elements of the article include historical review, rational analysis, value reconstruction, and macroscopic education objectives. This paper uses the method of historical analysis and literature review to provide guidance and reference for future school reform.
Big Brother Nigeria, Contemporary Youth Culture, and the Question of Nigeria’s Sustainable Future
Authors: Adebayo Abidemi Olufemi
Published: July 2024

Big Brother Naija, Nigeria’s localization of the international Big Brother Franchise, is the most subscribed reality show among the Nigerian youth. This is due to its explicit eroticism and lucrative rewards. The show is controversial as the libertine population believes in it while spiritual devotees and culture moralists see the show as social corruption. This study therefore explores the social implications of open eroticism and profligacy on the impressionable youth as this concerns Nigeria’s future sustainability. The research is guided by qualitative research principles and Diana Leat’s conception of Social Change Theory emphasizing culture as pivotal in progressive societal changes. The researcher relied on native intuition for research assertions and digital platforms for accessing videos and commentaries on the reality show. The paper opines that Nigerian youth’s repudiation of due process is injurious to the country’s future. Urgent government’s interventions are inevitable in redirecting the orientation of the Nigerian youth.
Der verarmte missachtete Gelehrte
Authors: Fechner Josephine
Published: July 2024

Der mesopotamische “leidende Gerechte” wurde bislang als eine weitestgehend homogene Figur bewertet: als ein gottesfürchtiger und rechtschaffener (aber nicht unfehlbarer!) Mensch, der trotz seiner redlichen Lebensführung unerklärliches Leiden in Form von Krankheiten, sozialem Abstieg und Verarmung ertragen muss. Anhand neuer Textquellen zum “leidenden Gerechten” aus der Brief- und Weisheitsliteratur wird in diesem Beitrag ein spezifischer Typ des “leidenden Gerechten” herausgearbeitet: der seit mindestens der altbabylonischen Zeit dokumentierte verarmte missachtete Gelehrte, oft in Form des abgesetzten königlichen Gelehrten, der neue Erkenntnisse zu den alten Fragen der mesopotamischen Theodizee zu vermitteln vermag: Wer ist (ursächlich) verantwortlich für unerklärliches menschliches Leiden? Nach dem verarmten missachteten Gelehrten ist das de facto die Menschheit selbst! Und wie kann unerklärliches Leiden gelöst, oder besser noch: verhindert werden, wenn nicht (allein) durch Gottesfurcht und Rechtschaffenheit? Theoretisch, indem ein Mensch “ein Haus mit guten Geistern” bewohnt, doch die praktische Umsetzung dieser Empfehlung bleibt schwierig.
The Evidence of Osiris Lord of Neheh-Eternity in Amun Temple B 700 at the Sacred Town of Gebel Barkal, Sudan
Authors: Petacchi Simone
Published: July 2024

This paper focuses on the analysis of a religious text coming from the reused blocks in Amun temple B 700 at the capital of the Napatan Kingdom (713–290 BCE), in the Sudan. This is the first fragmented Osirian hymn attested in Kush, while its integral version was found in Thebes, in the inner walls of the chapel erected by the Divine Adoratrice Ankhnesneferibre at Karnak North. The article presents the content of this hymn and its commentary, investigating the possible origins of the cult of this solarised form of Osiris associated to a local deity such as Dedwen in Nubia.
Wine Cups and the Early Chronology of Apollonia Pontica: Archaic Pottery from the Island of St. Kirik
Authors: Damyanov Margarit
Published: July 2024

In the last 15 years, the excavations at the island of St. Kirik offshore from Sozopol (ancient Apollonia Pontica) on the Bulgarian Black Sea coast have yielded thousands of fragments of Archaic Greek pottery, including a sizeable collection of drinking cups from the last decades of the 7th and the early 6th centuries BC – North Ionian hemispherical cups (“bird bowls”, “meander bowls”, etc.) and early types of South Ionian cups with everted rims (“Ionian cups”). The comparison with the assemblages from Istros, Berezan, Orgame, and Taganrog, all of them presumably earlier than Apollonia – with a traditional foundation date c.610 BC, reveals practically an identical repertoire. A couple of “anomalous” fragments that are even earlier, from the middle or third quarter of the 7th century BC, have parallels only at Berezan. The paper argues that there are grounds to suggest an earlier chronology of Apollonia’s foundation, closer to that of the other early Ionian apoikiai.