bluuebunny/crossref_metadata_2025 huggingface dataset:
Disease Progression and Serological Assay Performance in Heritage Breed Pigs following Brucella suis Experimental Challenge as a Model for Naturally Infected Feral Swine
Authors: Brown Vienna R. , Miller Ryan S. , Bowden Courtney F. , Smyser Timothy J. , Ledesma Nicholas A. , Hartwig Airn , Gordy Paul , Anderson Aaron M. , Porter Stephanie M. , Alexander Kate , Gouker Zane , Gidlewski Thomas , Bowen Richard A. , Bosco-Lauth Angela M.
Published: April 2023

Invasive feral swine (Sus scrofa) are one of the most important wildlife species for disease surveillance in the United States, serving as a reservoir for various diseases of concern for the health of humans and domestic animals. Brucella suis, the causative agent of swine brucellosis, is one such pathogen carried and transmitted by feral swine. Serology assays are the preferred field diagnostic for B. suis infection, as whole blood can be readily collected and antibodies are highly stable. However, serological assays frequently have lower sensitivity and specificity, and few studies have validated serological assays for B. suis in feral swine. We conducted an experimental infection of Ossabaw Island Hogs (a breed re-domesticated from feral animals) as a disease-free proxy for feral swine to (1) improve understanding of bacterial dissemination and antibody response following B. suis infection and (2) evaluate potential changes in the performance of serological diagnostic assays over the course of infection. Animals were inoculated with B. suis and serially euthanized across a 16-week period, with samples collected at the time of euthanasia. The 8% card agglutination test performed best, whereas the fluorescence polarization assay demonstrated no capacity to differentiate true positive from true negative animals. From a disease surveillance perspective, using the 8% card agglutination test in parallel with either the buffered acidified plate antigen test or the Brucella abortus/suis complement fixation test provided the best performance with the highest probability of a positive assay result. Application of these combinations of diagnostic assays for B. suis surveillance among feral swine would improve understanding of spillover risks at the national level.
Prescriptive Appropriateness: Inhospital Adherence to Proton Pump Inhibitors Deprescription Flow Chart
Authors: Baiardi Giammarco , Calvini Giulia , Panarello Serena , Fioravanti Chiara , Stella Manuela , Martelli Antonietta , Antonucci Giancarlo , Mattioli Francesca
Published: April 2023

The prescriptive appropriateness of Proton Pump Inhibitors (PPIs) in polypharmacy is controversial. PPIs are often overprescribed and the risk of prescribing errors and adverse drug reactions increases for each additional drug added to therapy. Hence, guided deprescription should be considered and easily implementable in ward practice. This observational prospective study evaluated the implementation of a validated PPIs deprescription flow chart to real-life internal ward activity through the presence of a clinical pharmacologist as an enhancing additional factor by assessment of inhospital prescriber’s adherence to the proposed flow chart. Patients’ demographics and prescribing trends of PPIs prescriptions were analyzed by descriptive statistics. The final analysis of data included ninety-eight patients (forty-nine male and forty-nine female), aging 75.6 ± 10.6 years; 55.1% of patients had home-PPIs prescriptions, while 44.9% received inhospital-PPIs prescriptions. Evaluation of prescriber’s adherence to the flow chart revealed that the percentage of patients with a prescriptive/deprescriptive pathway conforming to that of the flow chart was 70.4%, with low symptomatologic recurrences. The clinical pharmacologists’ presence and influence in ward activity may have contributed to this finding, since continuous training of the prescribing physicians is deemed a success-related factor in the deprescribing strategy. Multidisciplinary management of PPIs deprescription protocols shows high adherence by prescribers in real-life hospital settings and low recurrence events.
Calcifediol: Why, When, How Much?
Authors: Donati Simone , Marini Francesca , Giusti Francesca , Palmini Gaia , Aurilia Cinzia , Falsetti Irene , Iantomasi Teresa , Brandi Maria Luisa
Published: April 2023

Vitamin D deficiency is a constantly growing health problem worldwide. Adults affected with hypovitaminosis D could experience negative consequences on their musculoskeletal system and extra-skeletal health. In fact, an optimal vitamin D status is essential to ensure the correct bone, calcium, and phosphate homeostasis. To improve vitamin D status, it is important to not only increase the intake of food fortified with vitamin D, but also to administer vitamin D supplementation when required. Vitamin D3 (cholecalciferol) is the most widely used supplement. In recent years, the administration of calcifediol (25(OH)D3), the direct precursor of the biologically active form of vitamin D3, as oral vitamin D supplementation has progressively grown. Here, we report the potential medical benefits of some peculiar biological actions of calcifediol, discussing the possible specific clinical scenarios in which the oral intake of calcifediol could be most effective to restore the correct serum levels of 25(OH)D3. In summary, the aim of this review is to provide insights into calcifediol-related rapid non-genomic responses and the possible use of this vitamin D metabolite as a supplement for the treatment of people with a higher risk of hypovitaminosis D.
Association between Fluoxetine Use and Overall Survival among Patients with Cancer Treated with PD-1/L1 Immunotherapy
Authors: Magagnoli Joseph , Narendran Siddharth , Pereira Felipe , Cummings Tammy H. , Hardin James W. , Sutton S. Scott , Ambati Jayakrishna
Published: April 2023

Checkpoint inhibitors can be a highly effective antitumor therapy but only to a subset of patients, presumably due to immunotherapy resistance. Fluoxetine was recently revealed to inhibit the NLRP3 inflammasome, and NLRP3 inhibition could serve as a target for immunotherapy resistance. Therefore, we evaluated the overall survival (OS) in patients with cancer receiving checkpoint inhibitors combined with fluoxetine. A cohort study was conducted among patients diagnosed with lung, throat (pharynx or larynx), skin, or kidney/urinary cancer treated with checkpoint inhibitor therapy. Utilizing the Veterans Affairs Informatics and Computing Infrastructure, patients were retrospectively evaluated during the period from October 2015 to June 2021. The primary outcome was overall survival (OS). Patients were followed until death or the end of the study period. There were 2316 patients evaluated, including 34 patients who were exposed to checkpoint inhibitors and fluoxetine. Propensity score weighted Cox proportional hazards demonstrated a better OS in fluoxetine-exposed patients than unexposed (HR: 0.59, 95% CI 0.371–0.936). This cohort study among cancer patients treated with checkpoint inhibitor therapy showed a significant improvement in the OS when fluoxetine was used. Because of this study’s potential for selection bias, randomized trials are needed to assess the efficacy of the association of fluoxetine or another anti-NLRP3 drug to checkpoint inhibitor therapy.
Evidence of Strong Guest–Host Interactions in Simvastatin Loaded in Mesoporous Silica MCM-41
Authors: Cordeiro Teresa , Matos Inês , Danède Florence , Sotomayor João C. , Fonseca Isabel M. , Corvo Marta C. , Dionísio Madalena , Viciosa María Teresa , Affouard Frédéric , Correia Natália T.
Published: April 2023

A rational design of drug delivery systems requires in-depth knowledge not only of the drug itself, in terms of physical state and molecular mobility, but also of how it is distributed among a carrier and its interactions with the host matrix. In this context, this work reports the behavior of simvastatin (SIM) loaded in mesoporous silica MCM-41 matrix (average pore diameter ~3.5 nm) accessed by a set of experimental techniques, evidencing that it exists in an amorphous state (X-ray diffraction, ssNMR, ATR-FTIR, and DSC). The most significant fraction of SIM molecules corresponds to a high thermal resistant population, as shown by thermogravimetry, and which interacts strongly with the MCM silanol groups, as revealed by ATR-FTIR analysis. These findings are supported by Molecular Dynamics (MD) simulations predicting that SIM molecules anchor to the inner pore wall through multiple hydrogen bonds. This anchored molecular fraction lacks a calorimetric and dielectric signature corresponding to a dynamically rigid population. Furthermore, differential scanning calorimetry showed a weak glass transition that is shifted to lower temperatures compared to bulk amorphous SIM. This accelerated molecular population is coherent with an in-pore fraction of molecules distinct from bulklike SIM, as highlighted by MD simulations. MCM-41 loading proved to be a suitable strategy for a long-term stabilization (at least three years) of simvastatin in the amorphous form, whose unanchored population releases at a much higher rate compared to the crystalline drug dissolution. Oppositely, the surface-attached molecules are kept entrapped inside pores even after long-term release assays.
Recent Advances of Fe(III)/Fe(II)-MPNs in Biomedical Applications
Authors: Chen Weipeng , Liu Miao , Yang Hanping , Nezamzadeh-Ejhieh Alireza , Lu Chengyu , Pan Ying , Liu Jianqiang , Bai Zhi
Published: April 2023

Metal–phenolic networks (MPNs) are a new type of nanomaterial self-assembled by metal ions and polyphenols that have been developed rapidly in recent decades. They have been widely investigated, in the biomedical field, for their environmental friendliness, high quality, good bio-adhesiveness, and bio-compatibility, playing a crucial role in tumor treatment. As the most common subclass of the MPNs family, Fe-based MPNs are most frequently used in chemodynamic therapy (CDT) and phototherapy (PTT), where they are often used as nanocoatings to encapsulate drugs, as well as good Fenton reagents and photosensitizers to improve tumor therapeutic efficiency substantially. In this review, strategies for preparing various types of Fe-based MPNs are first summarized. We highlight the advantages of Fe-based MPNs under the different species of polyphenol ligands for their application in tumor treatments. Finally, some current problems and challenges of Fe-based MPNs, along with a future perspective on biomedical applications, are discussed.
Modulation of Transcription Profile Induced by Antiproliferative Thiosemicarbazone Metal Complexes in U937 Cancer Cells
Authors: Montalbano Serena , Bisceglie Franco , Pelosi Giorgio , Lazzaretti Mirca , Buschini Annamaria
Published: April 2023

Since the discovery of cisplatin, the search for metal-based compounds with therapeutic potential has been a challenge for the scientific community. In this landscape, thiosemicarbazones and their metal derivatives represent a good starting point for the development of anticancer agents with high selectivity and low toxicity. Here, we focused on the action mechanism of three metal thiosemicarbazones [Ni(tcitr)2], [Pt(tcitr)2], and [Cu(tcitr)2], derived from citronellal. The complexes were already synthesized, characterized, and screened for their antiproliferative activity against different cancer cells and for genotoxic/mutagenic potential. In this work, we deepened the understanding of their molecular action mechanism using an in vitro model of a leukemia cell line (U937) and an approach of transcriptional expression profile analysis. U937 cells showed a significant sensitivity to the tested molecules. To better understand DNA damage induced by our complexes, the modulation of a panel of genes involved in the DNA damage response pathway was evaluated. We analyzed whether our compounds affected cell cycle progression to determine a possible correlation between proliferation inhibition and cell cycle arrest. Our results demonstrate that metal complexes target different cellular processes and could be promising candidates in the design of antiproliferative thiosemicarbazones, although their overall molecular mechanism is still to be understood.
Extracellular Vesicle-Based Drug Delivery Systems for Head and Neck Squamous Cell Carcinoma: A Systematic Review
Authors: Dżaman Karolina , Czerwaty Katarzyna
Published: April 2023

It is estimated that there are over 890,000 new cases of head and neck squamous cell carcinoma (HNSCC) worldwide each year, accounting for approximately 5% of all cancer cases. Current treatment options for HNSCC often cause significant side effects and functional impairments, thus there is a challenge to discover more acceptable treatment technologies. Extracellular vesicles (EVs) can be utilized for HNSCC treatment in several ways, for example, for drug delivery, immune modulation, as biomarkers for diagnostics, gene therapy, or tumor microenvironment modulation. This systematic review summarizes new knowledge regarding these options. Articles published up to 11 December 2022, were identified by searching the electronic databases PubMed/MEDLINE, Scopus, Web of Science, and Cochrane. Only full-text original research papers written in English were considered eligible for analysis. The quality of studies was assessed using the Office of Health Assessment and Translation (OHAT) Risk of Bias Rating Tool for Human and Animal Studies, modified for the needs of this review. Of 436 identified records, 18 were eligible and included. It is important to note that the use of EVs as a treatment for HNSCC is still in the early stages of research, so we summarized information on challenges such as EV isolation, purification, and standardization of EV-based therapies in HNSCC.
An Update on Recent Advances of Photodynamic Therapy for Primary Cutaneous Lymphomas
Authors: Liu Wei-Ting , Wang Han-Tang , Yeh Yi-Hsuan , Wong Tak-Wah
Published: April 2023

Primary cutaneous lymphomas are rare non-Hodgkin lymphomas consisting of heterogeneous disease entities. Photodynamic therapy (PDT) utilizing photosensitizers irradiated with a specific wavelength of light in the presence of oxygen exerts promising anti-tumor effects on non-melanoma skin cancer, yet its application in primary cutaneous lymphomas remains less recognized. Despite many in vitro data showing PDT could effectively kill lymphoma cells, clinical evidence of PDT against primary cutaneous lymphomas is limited. Recently, a phase 3 “FLASH” randomized clinical trial demonstrated the efficacy of topical hypericin PDT for early-stage cutaneous T-cell lymphoma. An update on recent advances of photodynamic therapy in primary cutaneous lymphomas is provided.
All-Fiber Laser Feedback Interferometry for Sequential Sensing of In-Plane and Out-of-Plane Displacements
Authors: Xie Zhanwu , Zhang Meng , Li Jie , Xia Wei , Guo Dongmei
Published: April 2023

In this paper, an all-fiber laser feedback interferometer (LFI) with a diffraction grating was developed for sequential measurement of in-plane and out-of-plane displacements without changing the optical arrangement. When the light emitted from an erbium-doped fiber ring laser is incident on a reflection grating at the Littrow angle, the diffracted light will return into the laser cavity along the original path, thus generating laser feedback interference. Experimental results reveal that the all-fiber system could achieve a precision of 40 nm in both in-plane and out-of-plane displacements sensing. Compared with the traditional all-fiber LFI, the proposed sensing system transfers the measuring scale from laser wavelength to grating period, and it has the advantages of good anti-interference performance and reliability.
Guided-Wave Properties of Slow-Wave Substrate-Integrated Waveguide Patterned with Non-Uniform Metasurface Unit Cells with Various Degrees of Rotation
Authors: Jin Hailu , Jing Xiaorong , Wang Ping
Published: April 2023

A novel slow-wave waveguide structure is proposed, the guided-wave properties of which can be controlled by the rotation of nonuniform metasurface elements loaded on the surface of the substrate-integrated waveguide. The proposed nonuniform metasurface unit cell can exhibit anisotropic guided-wave parameters of interest, i.e., equivalent permittivity and permeability along the transverse direction that are different from those along the longitudinal direction. Such characteristics suggest different propagation behaviors along different directions. Therefore, the equivalent permittivity and permeability change as the proposed nonuniform cross-unit cell rotates through various angles, which would modify the guided-wave properties as well. In this way, the cutoff frequency and phase constant of the proposed anisotropic SW-SIW can be controlled flexibly by rotating the patterned metasurface unit cells over different angles. Several SW-SIW experimental prototypes with different rotation angles are implemented, and their respective measured results are in good agreement with their simulated counterparts. Thereby, the proposed method can provide more flexibility for designing and controlling an anisotropic SW-SIW.
Velocity Filtering Using Quantum 3D FFT
Authors: Koukiou Georgia , Anastassopoulos Vassilis
Published: April 2023

In this work, the quantum version of 3D FFT is proposed for constructing velocity filters. Velocity filters are desirable when we need to separate moving objects with a specific velocity range in amplitude and direction in a rapidly changing background. These filters are useful in many application fields, such as for monitoring regions for security reasons or inspecting processes in experimental physics. A faster and more attractive way to implement this filtering procedure is through 3D FFT instead of using 3D FIR filters. Additionally, 3D FFT provides the capability to create banks of ready-made filters with various characteristics. Thus, 3D filtering is carried out in the frequency domain by rejecting appropriate frequency bands according to the spectral content of the trajectory of the object to be isolated. The 3D FFT procedure and the corresponding inverse one are required in the beginning and end of the filtering process. Although 3D FFT is computationally effective, it becomes time-consuming when we need to process large data cubes. The implementation of velocity filters by means of the quantum version of 3D FFT is investigated in this work. All necessary quantum circuits and quantum procedures needed are presented in detail. This proposed quantum structure results in velocity filtering with a short execution time. For this purpose, a review of the necessary quantum computational units is presented for the implementation of quantum 3D FFT and representative examples of applications of velocity filtering are provided.
Investigating the Thermometric Performance of Inorganic Materials Doped with Nd3+ under Infrared LED Excitation: An Alternative for Deep Tissue Luminescent Thermometry
Authors: Laia André S. , Hora Daniela A. , Rezende Marcos V. dos S. , Gomes Maria A. , Brandão-Silva Antônio C. , Santos Marcos A. C. dos , Dantas Noelio O. , Silva Anielle C. A. , Rodrigues José J. , Valerio Mário E. G. , Macedo Zélia S. , Alencar Márcio A. R. C.
Published: April 2023

Luminescent thermometers based on the luminescence intensity ratio between two thermally coupled levels have a strong appeal in the biomedical area due to the possibility of monitoring the temperature of deep tissues. In such procedures, it is necessary that the excitation and emission wavelengths are within the biological windows. Probes based on neodymium luminescence, with excitation and emission around 800 and 880 nm, are frequently proposed but have low relative sensitivity (0.2%.K−1) due to the small energy separation between the explored Stark sublevels. By changing the excitation wavelength to around 750 nm, it is possible to explore the thermal coupling between the 4F5/2 and 4F3/2 levels. However, lasers in this wavelength range are not common. An alternative is to use LEDs as an excitation source. As a proof of concept, we investigated the thermometric performance of three distinct Nd-doped luminescent probes under 730 nm LED excitation and 532 nm laser excitation: nanocrystalline Y2O3, LiBaPO4 microcrystals, and lithium-boron-aluminum (LBA) glass. The results indicated that the use of LEDs as an excitation source can be applied in nano-, micro- and macro-structured probes, as it does not compromise the thermometric performance of the systems, which exhibited relative sensitivities of approximately 2%.K−1.
Generation and Manipulation of Airy Breathing Solitons in an Inhomogeneous Medium with Periodic Potential
Authors: Gao Chunhui , Wen Bing , Deng Yangbao , Fan Yingqi , Wei Jiamou , Chen Depeng
Published: April 2023

The propagation characteristics of Airy beams in an inhomogeneous medium with periodic potential are studied theoretically and numerically. The Gross–Pitaevskii equation was solved with periodic potential using the separating variables method, and a breathing soliton solution and the breathing period were obtained. Further, the propagation properties of an Airy beam, and the interaction between two Airy beams while considering the medium parameters and beam parameters were numerically simulated in detail. First, we discuss the influence of the initial medium parameters (modulation intensity P and modulation frequency ω) on the propagation characteristics. Then, we investigate the effect of the initial beam parameters (initial chirp C and position x0) on the propagation characteristics. Lastly, the interaction of two Airy beams with opposite spatial positions for different phase φ, amplitude A, and initial interval x0 is analyzed. The breathing period and central position of the breathing solitons could be controlled by changing the initial medium parameters. By varying the initial beam parameters, the deflection direction and size, and the maximal intensity of the breathing solitons were manipulated. The breathing solitons of different bound states were formed by changing the phase φ, amplitude A, and initial interval x0 of two Airy beams. The results provide a theoretical basis for the propagation and manipulation of Airy beams.
Temperature Changes during Er:YAG Laser Activation with the Side-Firing Spiral Endo Tip in Root Canal Treatment
Authors: Sahar-Helft Sharonit , Sebbane Nathanyel , Farber Adi , Sionov Ronit Vogt , Dakar Roni , Steinberg Doron
Published: April 2023

Erbium-doped yttrium aluminum garnet (Er:YAG) laser-activated irrigation (LAI) is used in endodontic treatment to remove the smear layer and kill bacteria in the root canal. However, this procedure can cause photo-thermal effects that harm the surrounding tissue. Therefore, it was important to study the temperature changes that occur at the outer tooth surface during activation of the Er:YAG laser using a side-firing spiral Endo tip in the root canal. Laser treatment was performed either in the absence of fluid in the root canal or in the presence of a 17% EDTA solution. Irrigation with 17% EDTA was either performed in a continuous mode for 60 s or in a segmented mode of 4 rinses with 17% EDTA for 15 s each. The temperature was measured every second during the treatment at three tooth surface sites: the cementoenamel junction, the middle region and the apical region. Our data show that the greatest temperature changes occurred when the laser was used alone without an irrigation solution, while minor temperature changes were observed with continuous irrigation. In conclusion, we would recommend applying the laser treatment with an irrigation solution to avoid excessive heating.
Shading Stress at Different Grain Filling Stages Affects Dry Matter and Nitrogen Accumulation and Remobilization in Fresh Waxy Maize
Authors: Sun Haohan , Li Wei , Liang Yuwen , Li Guanghao
Published: April 2023

Shading stress caused by plum rain season, which overlapped with grain filling process of fresh waxy maize in Southern China, significantly affected crop productivity. In order to investigate the effects of shading at different stages after pollination on the yield, accumulation, and remobilization of dry matter and nitrogen (N) in fresh waxy maize, field experiments were conducted, including shading at 1–7 (Z1), 8–14 (Z2), 15–21 (Z3), and 1–21 (Z4) days after pollination in 2020 and 2021. The results showed that shading reduced the fresh ear and grain yield and increased moisture content in Suyunuo5 (SYN5) and Jingkenuo2000 (JKN2000) compared to natural lighting treatment (CK). The ear yield decrease was more severe in Z4 (43.5%), followed by Z1 (29.7%). Post-silking dry matter and N accumulation and remobilization were decreased under shading stress, and those were lowest in Z4, followed by Z1. The remobilization of pre-silking dry matter and N were increased by shading stress, and the increase was highest in Z4, followed by Z1. The harvest index of dry matter and N was lowest in Z4 and second-lowest in Z1. In conclusion, shading decreased yield by affecting accumulation and remobilization of post-silking dry matter and N, and the impact was more serious when it introduced early during grain filling stage in fresh waxy maize production.
New Data on Native and Alien Vascular Flora of Sicily (Italy): New Findings and Updates
Authors: Cambria Salvatore , Azzaro Dario , Caldarella Orazio , Aleo Michele , Bazan Giuseppe , Guarino Riccardo , Torre Giancarlo , Cristaudo Antonia Egidia , Ilardi Vincenzo , La Rosa Alfonso , Laface Valentina Lucia Astrid , Luchino Fabio , Mascia Francesco , Minissale Pietro , Sciandrello Saverio , Tosetto Luca , Tavilla Gianmarco
Published: April 2023

In this paper, based on fieldwork and herbaria surveys, new data concerning the presence of 32 native and alien vascular species for Sicily (Italy) are provided. Among the native species, the occurrence of the following taxa is reported for the first time or confirmed after many decades of non-observation: Aira multiculmis, Arum maculatum, Carex flacca subsp. flacca, Mentha longifolia, Oxybasis chenopodioides, Najas minor and Xiphion junceum. Furthermore, we document the presence of three native species (Cornus mas, Juncus foliosus and Limonium avei) that, despite being repeatedly observed in Sicily and reported in the literature, are inexplicably omitted by the most recent authoritative checklists regarding the flora of Italy. Finally, fifteen alien species new to Sicily (including one new to Europe, i.e., Pyrus betulifolia) are reported and seven poorly documented allochthonous taxa are confirmed for the island, and for two of them, a status change is proposed. These new or confirmed records allow us to better define the European and national distribution of the targeted taxa and offer new insights on the native and alien flora of Sicily.
Blending of the Thermodynamically Incompatible Polyvinyl Chloride and High-Pressure Polyethylene Polymers Using a Supercritical Fluid Anti-Solvent Method (SEDS) Dispersion Process
Authors: Khairutdinov Vener F. , Khabriev Ilnar Sh. , Gumerov Farid M. , Khuzakhanov Rafail M. , Garipov Ruslan M. , Yarullin Lenar Yu. , Abdulagatov Ilmutdin M.
Published: April 2023

The experimental solubility data of polyvinyl chloride (PVC) and high-pressure polyethylene (HPPE) in organic solvents (toluene, dichloromethane, and chloroform) at temperatures ranging from 308.15 to 373.15 K at atmospheric pressure are reported in the present paper. The solubility of the polymers (PVC and HPPE) in organic solvents (toluene, dichloromethane, and chloroform) was studied at temperatures between 298 and 373 K. The supercritical SEDS dispersion of PVC and HPPE polymer blends at pressures between 8.0 and 25 MPa and at temperatures from 313 to 333 K are reported in the present work. The kinetics of crystallization and phase transformation in polymer blends obtained by blending in a melt, and using the supercritical SEDS method, have been studied. The effect of the HPPE/PVC ratio on the thermal and mechanical characteristics of the polymer blends has been studied. For all studied polymer blends and pure polymers obtained using the SEDS method, the heat of fusion ΔfusH exceeds the values obtained by blending in the melt by 1.5 to 5) times. The heat of fusion of the obtained polymer blends is higher than the additive value; therefore, the degree of crystallinity is higher, and this effect persists after heat treatment. The relative elongation decreases for all polymer blends, but their tensile strength increases significantly.
Sustainable Cotton Gin Waste/Polycaprolactone Bio-Plastic with Adjustable Biodegradation Rate: Scale-Up Production through Compression Moulding
Authors: Cai Zengxiao , Haque Abu Naser Md Ahsanul , Dhandapani Renuka , Naebe Maryam
Published: April 2023

Cotton gin trash (CGT), a lignocellulosic waste generated during cotton fibre processing, has recently received significant attention for production of composite bio-plastics. However, earlier studies were limited to either with biodegradable polymers, through small-scale solution-casting method, or using industrially adaptable extrusion route, but with non-biodegradable polymers. In this study, a scale-up production of completely biodegradable CGT composite plastic film with adjustable biodegradation rate is proposed. First using a twin screw extruder, the prepared CGT powder was combined with polycaprolactone (PCL) to form pellets, and then using the compressing moulding, the pellets were transformed into bio-plastic composite films. Hydrophilic polyethylene glycol (PEG) was used as a plasticiser in the mixture and its impact on the biodegradation rate was analysed. The morphology of CGT bio-plastic composite films showed even distribution of CGT powder within the PCL matrix. The CGT incorporation improved the UV resistance, thermal stability, and Young’s modulus of PCL material. Further, the flexibility and mixing properties of the composites were improved by PEG. Overall, this study demonstrated a sustainable production method of CGT bio-plastic films using the whole CGT and without any waste residue produced, where the degradation of the produced composite films can be adjusted to minimise the environmental impact.
Star-Shaped Thermoplastic Elastomers Prepared via RAFT Polymerization
Authors: Ge Hao , Shi Wencheng , He Chen , Feng Anchao , Thang San H.
Published: April 2023

Styrene-based thermoplastic elastomers (TPEs) demonstrate excellent overall performance and account for the largest industrial output. The traditional methods of preparation styrene-based thermoplastic elastomers mainly focused on anionic polymerization, and strict equipment conditions were required. In recent years, controlled/living radical polymerization (CRP) has developed rapidly, enabling the synthesis of polymers with various complex topologies while controlling their molecular weight. Herein, a series of core crosslinked star-shaped poly(styrene-b-isoprene-b-styrene)s (SISs) was synthesized for the first time via reversible addition–fragmentation chain transfer (RAFT) polymerization. Meanwhile, linear triblock SISs with a similar molecular weight were synthesized as a control. We achieved not only the controlled/living radical polymerization of isoprene but also investigated the factors influencing the star-forming process. By testing the mechanical and thermal properties and characterizing the microscopic fractional phase structure, we found that both the linear and star-shaped SISs possessed good tensile properties and a certain phase separation structure, demonstrating the characteristics of thermoplastic elastomers.
Elastic Electrically Conductive Composites Based on Vapor-Grown Carbon Fibers for Use in Sensors
Authors: Nasr Ahmed , Mrhálek Ondřej , Svoboda Petr
Published: April 2023

Elastic electrically conductive composites with an ethylene octene copolymer matrix (EOC) and vapor-grown carbon fibers (VGCF) were prepared by ultrasonication in a toluene solution, and their morphology, mechanical and electrical properties were also evaluated. EOC/CF composites were estimated for their mechanical and viscoelastic properties. The morphology of the composites was analyzed using scanning electron microscopy (SEM), and stress–strain curves were generated to measure the stress and tensile modulus of the composites. The experimental results were compared with various theoretical models, including the Burgers model, which separates viscoelastic behavior into several components. A dynamic mechanical analysis was also used to measure the composites’ storage modulus, loss modulus, and damping factor at different frequencies. The composites’ complex viscosity and storage modulus were increased with higher wt.% of CF, which enhances the elastic response. Electrical resistivity measurements were conducted on the composites and it was found that the resistivity decreased as the sample was loaded and increased as it was unloaded. Overall, the study provides insights into the mechanical and viscoelastic properties of EOC/CF composites, which could be helpful in developing sensors such as pressure/strain sensors.
Antidiabetic Plants for the Treatment of Type 2 Diabetes Mellitus and Associated Bacterial Infections
Authors: Tienda-Vázquez Mario Adrián , Melchor-Martínez Elda M. , Elizondo-Luévano Joel H. , Parra-Saldívar Roberto , Lara-Ortiz Javier Santiago , Luna-Sosa Brenda , Scheckhuber Christian Quintus
Published: April 2023

Type 2 diabetes mellitus (T2DM) is the metabolic disease with the highest morbidity rates worldwide. The condition is characterized by hyperglycemia, insulin resistance, hyperlipidemia, and chronic inflammation, among other detrimental conditions. These decrease the efficiency of the immune system, leading to an increase in the susceptibility to bacterial infections. Maintaining an optimal blood glucose level is crucial in relation to the treatment of T2DM, because if the level of this carbohydrate is lowered, the risk of infections can be reduced. Currently, this is achieved using synthetic drug treatments that seek to moderately inhibit digestive enzymes (e.g., α-amylase and α-glucosidase), such as acarbose, voglibose, miglitol, etc. However, the use of these compounds also generates unwanted side effects such as nausea, diarrhea, stomach aches and a loss of appetite. Therefore, there is an increasing demand to find effective and safe alternatives for treating T2DM, such as herbal treatments. As a result, there has been a search for possible drugs from plants with both antidiabetic and antibacterial activity. This study presents a review of the molecular and cellular mechanisms of T2DM, secondary effects of the disease such as bacterial infections, and general comprehension of synthetic and natural product treatments to help patients.
Sustainable Routes for Wool Grease Removal Using Green Solvent Cyclopentyl Methyl Ether in Solvent Extraction and Biosurfactant Wool Protein Hydrolyzate in Scouring
Authors: Bhavsar Parag , Zoccola Marina , Dalla Fontana Giulia , Pallavicini Marco , Roda Gabriella , Bolchi Cristiano
Published: April 2023

This work focuses on introducing new sustainable chemicals in the wool grease removal processes by aiming to understand the effect of an eco-friendly solvent, cyclopentyl methyl ether (CPME), in solvent-based wool grease extraction and, in addition, the impact of the wool protein hydrolyzate (WPH) as a biosurfactant derived from green hydrolysis in the wool scouring process. In the green solvent extraction process assisted using solvent CPME, the effect of CPME on grease extraction and the presence of four primary fatty acids were evaluated and compared with conventional solvents. The quantity of grease extracted using green solvent CPME was more significant than the conventional solvents. An extraction using green solvent CPME resulted in 11.95% extracted wool grease, which is more when compared with 8.19% hexane and 10.28% diethyl ether. The total quantity of four fatty acids was analyzed and found to be ~15% for CPME ~17% for Hexan compared with ~20% for commercial lanolin. FTIR of CPME-extracted wool grease exhibits primary and distinguishing bands similar to pure wool grease. Wool cleanliness efficiency was morphologically analyzed using SEM, resulting in no fiber degradation or surface alterations. These analyzes indicated that CPME has the potential to be claimed as an effective green alternative to conventional solvents for the extraction of grease and fatty acids. In a sustainable scouring process, WPH was used as a biosurfactant, an eco-friendly alternative. Furthermore, scouring process parameters such as temperature, material-to-liquor ratio, and WPH concentration were optimized for efficient scouring. The wool samples scoured using WPH biosurfactant exhibited nearly similar whiteness and yellowness and washing yield compared with Biotex AL. These results comply with SEM analysis, which showed that WPH-scoured wool had an intact scale structure, a smooth fiber surface, and no wool grease layer. At optimum conditions, WPH reduced the residual grease content of Sopravissana wool from 22.29% to 0.30%, comparable to the commercial biosurfactant Biotex AL. Compared with conventional wool grease removal processes, the green solvent CPME and biosurfactant WPH were considered viable, sustainable, and environmentally friendly alternatives.
Gas–Water Characteristics of Tight Sandstone in Xihu Sag, East China Sea Basin under Different Charging Models
Authors: Chen Jinlong , Huang Zhilong , Yao Genshun , Fan Hongche
Published: April 2023

The Xihu sag has two main oil−gas fields: Huagang Gas Field and Pinghu Oil Field. The Huagang formation is the reservoir of the Huagang Gas Field in the Central Tectonic Zone, while the Pinghu formation is the reservoir of the Pinghu Oil Field in the Western Slope Zone. In this paper, which mainly focusses on the Huagang formation, we conducted gas-driven water displacement–magnetic resonance imaging (GWD-MRI) experiments to simulate the charging characteristics of the sandstone migration layer, centrifugal magnetic resonance (Cen-NMR) experiments to simulate the short-term rapid trap charging process, and semi-permeable baffle (SPB) charging experiments to simulate the slow trap accumulation process. The results indicate that a start-up pressure exists for migration layer charging, where the start-up pressure for a core with a permeability of 0.3 mD is about 0.6 MPa. Our experimental simulations confirm that a planar front of changing water saturation exists, which has a width of about 1–1.5 cm. Migration layer charging is mainly influenced by two actions: the drive effect and the carrying effect. The drive effect can reduce the water saturation to 70–80%, while the carrying effect can further reduce the water saturation by 5–10%. The water saturation in the rapid charging scenario is mainly affected by the petrophysical characteristics of the rock: if the porosity is high, the water saturation is low. The water saturation decreases significantly with the increase in centrifugal force when the centrifugal force is small; however, when the centrifugal force is greater than 0.8 MPa, the water saturation decreases slowly. In the slowly charging trap experiment, the water saturation was basically stable at 40–50%, which matched the measured water saturation of the airtight cores well (ranging from 40–55%), and the petrophysical characteristics of the rock did not have a significant effect on the final water saturation.
A Multi-Criteria Decision-Making Process for the Selection of an Efficient and Reliable IoT Application
Authors: Alojaiman Bader
Published: April 2023

Saudi Arabia initiated its much-anticipated Vision 2030 campaign, a long-term economic roadmap aimed at reducing the country’s reliance on oil. The vision, which is anticipated to be accomplished in the future, underlines compliance, fiscal, and strategy adjustments that will significantly affect all the important features of Saudi economic growth. Technology will be a critical facilitator, as well as controller, of the initiative’s significant transformation. Cloud computing, with the Internet of things (IoT), could make significant contributions to Saudi Vision 2030’s efficient governance strategy. There are multiple IoT applications that cover every part of everyday life, as well as enabling users to use a variety of IoT applications. Choosing the best IoT applications for specific customers is a difficult task. This paper concentrates on the Kingdom’s advancement towards a fresh, as well as enhanced, method of advancing the development phases pertaining to digital transformation, through implementing and adopting modern communications infrastructure and ICT technology. In addition, this study proposes a recommendation system that relies on a multi-criteria decision-making investigation focusing on the fuzzy TOPSIS method for selecting highly efficient IoT applications. The prototype, as well as the hierarchy, was created to assess and correlate critical criteria based on specialist preferences and recommendations. The T5 IoT application alternative was shown to be the most highly effective and reliable choice according to the findings of both fuzzy TOPSIS and TOPSIS.
Designing an Efficient Surfactant–Polymer–Oil–Electrolyte System: A Multi-Objective Optimization Study
Authors: Nedjhioui Mohammed , Nasrallah Noureddine , Kebir Mohammed , Tahraoui Hichem , Bouallouche Rachida , Assadi Aymen Amin , Amrane Abdeltif , Jaouadi Bassem , Zhang Jie , Mouni Lotfi
Published: April 2023

This research aimed to study the effects of individual components on the physicochemical properties of systems composed of surfactants, polymers, oils, and electrolytes in order to maximize the recovery efficiency of kerosene while minimizing the impact on the environment and human health. Four independent factors, namely anionic surfactant sodium dodecylbenzene sulfonate (X1) (SDBS), oil (X2) (kerosene), water-soluble polymer poly(ethylene glycol) (X3) (PEG), and sodium chloride (X4) (NaCl), were studied using the full factorial design (FFD) model. Four output variables, namely conductivity (Y1), turbidity (Y2), viscosity (Y3), and interfacial tension (IFT) (Y4), were taken as the response variables. All four FFD models have high coefficients of determination and low errors. The developed models were used in a multi-objective optimization (MOO) framework to determine the optimal conditions. The obtained optimal conditions are X1 = 0.01, X2 = 50, X3 = 5, and X4 = 0.1, with an error of 0.9414 between the predicted and experimental objective function values. This result shows the efficiency of the model developed and the system used for the recovery of kerosene, while also having a positive effect on the protection of the environment.
Preaching Muslim Loyalty in France: Rhetoric and Counter-Discourse
Authors: Belhaj Abdessamad
Published: April 2023

This paper analyzes online sermons on Muslim loyalty to non-Muslims uttered by Tareq Oubrou, one of the most prominent Muslim religious authorities in France. The aim of this study is twofold. First, Oubrou’s rhetoric will be examined (especially in what pertains to the opening, the hybrid format of preaching, the languages used, citations, digital tools, and the closing). Second, Oubrou’s online sermons will be addressed as a counter-narrative on loyalty intended primarily to neutralize the radical Salafi discourses which forbid any form of loyalty towards non-Muslims. Oubrou utilizes online preaching: (1) to teach wider audiences of ordinary Muslims, outside of the practicing audience who attend mosques regularly, loyalty towards non-Muslims; (2) to compete for space and authoritative discourse on Islam; and (3) to prosecute radical discourses on loyalty particularly present in the virtual space as well as among undersized, albeit active, Salafi communities in France.
Estimating the Value-at-Risk by Temporal VAE
Authors: Buch Robert , Grimm Stefanie , Korn Ralf , Richert Ivo
Published: April 2023

Estimation of the value-at-risk (VaR) of a large portfolio of assets is an important task for financial institutions. As the joint log-returns of asset prices can often be projected to a latent space of a much smaller dimension, the use of a variational autoencoder (VAE) for estimating the VaR is a natural suggestion. To ensure the bottleneck structure of autoencoders when learning sequential data, we use a temporal VAE (TempVAE) that avoids the use of an autoregressive structure for the observation variables. However, the low signal-to-noise ratio of financial data in combination with the auto-pruning property of a VAE typically makes use of a VAE prone to posterior collapse. Therefore, we use annealing of the regularization to mitigate this effect. As a result, the auto-pruning of the TempVAE works properly, which also leads to excellent estimation results for the VaR that beat classical GARCH-type, multivariate versions of GARCH and historical simulation approaches when applied to real data.
Denoising Diffusion Probabilistic Feature-Based Network for Cloud Removal in Sentinel-2 Imagery
Authors: Jing Ran , Duan Fuzhou , Lu Fengxian , Zhang Miao , Zhao Wenji
Published: April 2023

Cloud contamination is a common issue that severely reduces the quality of optical satellite images in remote sensing fields. With the rapid development of deep learning technology, cloud contamination is expected to be addressed. In this paper, we propose Denoising Diffusion Probabilistic Model-Cloud Removal (DDPM-CR), a novel cloud removal network that can effectively remove both thin and thick clouds in optical image scenes. Our network leverages the denoising diffusion probabilistic model (DDPM) architecture to integrate both clouded optical and auxiliary SAR images as input to extract DDPM features, providing significant information for missing information retrieval. Additionally, we propose a cloud removal head adopting the DDPM features with an attention mechanism at multiple scales to remove clouds. To achieve better network performance, we propose a cloud-oriented loss that considers both high- and low-frequency image information as well as cloud regions in the training procedure. Our ablation and comparative experiments demonstrate that the DDPM-CR network outperforms other methods under various cloud conditions, achieving better visual effects and accuracy metrics (MAE = 0.0229, RMSE = 0.0268, PSNR = 31.7712, and SSIM = 0.9033). These results suggest that the DDPM-CR network is a promising solution for retrieving missing information in either thin or thick cloud-covered regions, especially when using auxiliary information such as SAR data.
Comparison of Different Remotely Sensed Data Sources for Detection of Presence of Standing Dead Trees Using a Tree-Based Approach
Authors: Jutras-Perreault Marie-Claude , Gobakken Terje , Næsset Erik , Ørka Hans Ole
Published: April 2023

Deadwood is an important key ecological element for forest ecosystem biodiversity. Its low occurrence, especially in managed forests, makes inventory through field campaigns challenging. Remote sensing can provide a more objective and systematic approach to detect deadwood for large areas. Traditional area-based approaches have, however, shown limitations when it comes to predicting rare objects such as standing dead trees (SDT). To overcome this limitation, this study proposes a tree-based approach that uses a local maxima function to identify trees from airborne laser scanning (ALS) and optical data, and predict their status, i.e., living or dead, from normalized difference vegetation index (NDVI). NDVI was calculated from aerial images (hyperspectral and simulated aerial image) and from satellite images (PlanetScope and Sentinel-2). By comparing the different remotely sensed data sources, we aimed to assess the impact of spatial and spectral resolutions in the prediction of SDT. The presence/absence of SDT was perfectly predicted by combining trees identified using ALS-derived canopy height models with spatial resolutions between 0.75 m and 1 m and a search window size of 3 pixels, and NDVI computed from aerial images to predict their status. The presence/absence of SDT was not predicted as accurately when using NDVI computed from satellite images. A root-mean-square deviation of around 35 trees ha−1 was obtained when predicting the density of SDT with NDVI from aerial images and around 60 trees ha−1 with NDVI from satellite images. The tree-based approach presented in this study shows great potential to predict the presence of SDT over large areas.