bluuebunny/crossref_metadata_2025 huggingface dataset:
Examining the Double-Edged Sword Effects of Lay Theories of Mental Health on Perceptions and Treatment of Others with Mental Health Problems
Authors: Erb Emily M. , Busseri Michael A.
Published: August 2022

INTRODUCTION: We examined the implications of viewing mental health problems as changeable through personal effort (incremental lay theory), fixed due to genetics (entity lay theory), or manageable through perseverance on perceptions of others with mental health problems. METHOD: In two preregistered studies, samples of online American participants were randomly assigned to one of four experimental conditions: manageable, incremental (changeable), entity (fixed), or control, and completed self-report measures of onset responsibility, offset efficacy, blame, stigma, willingness to help, and perceived likelihood of success of interventions aimed at helping those with mental health problems. RESULTS: In both studies, the manipulation had a significant effect on each outcome except willingness to help. Compared to the entity (fixed) condition, individuals in the incremental (changeable) condition reported significantly higher offset efficacy and perceived likelihood of success, but also higher onset responsibility and blame. Results for the manageable condition were similar to the incremental (changeable) condition but individuals in the manageable condition also reported lower responsibility (Study 1) as well as lower blame and stigma (Study 2). DISCUSSION: This work informs the ‘double-edged sword’ effects of holding incremental (changeable) or entity (fixed) lay theories concerning mental health problems. Findings also provide evidence that viewing mental health problems as manageable may reduce some of the negative and boost the positive implications associated with incremental (changeable) and entity (fixed) lay theories.
Rumination in Borderline Personality Disorder: A Meta-analytic Review
Authors: Richman Czégel Mara J. , Unoka Zsolt , Dudas Robert B. , Demetrovics Zsolt
Published: August 2022

Borderline personality disorder (BPD) is characterized by deficits in emotion regulation and affective liability, specifically rumination. Despite this, inconsistencies have existed in the literature regarding which rumination type is most prominent in BPD. Taking this into consideration, a meta-analysis was performed to look at how BPD symptoms correlate with rumination, while also considering clinical moderator variables (i.e., BPD symptom domain, comorbidities, GAF score) and demographic moderator variables (i.e., age, gender, sample type, and education level). Analysis of rumination domains for the entire sample revealed a medium correlation between BPD symptoms and rumination. When types of rumination were assessed, the largest correlation was among pain rumination followed by anger, depressive, and anxious rumination. Among BPD symptom domain, affective instability had the strongest correlation with increased rumination, followed by unstable relationships, identity disturbance, and self-harm/impulsivity. Demographic variables showed no significance. Clinical implications and further therapeutic interventions are discussed considering rumination.
Dialectical Behavior Therapy for Individuals With Borderline Personality Disorder: A Systematic Review of Outcomes After One Year of Follow-Up
Authors: Gillespie Conall , Murphy Mike , Joyce Mary
Published: August 2022

Dialectical behavior therapy (DBT) has a growing evidence base for treating individuals with a diagnosis of borderline personality disorder (BPD). Less is known about the long-term effects of the treatment, which is an important consideration when treating a chronic disorder such as BPD. The current systematic review explores outcomes after 1 year of follow-up for individuals who engaged in DBT. A systematic search of four databases (PsycInfo, PubMed, Scopus, CINAHL) was performed. Controlled and uncontrolled studies were included. A total of 10 articles were identified pertaining to seven primary research studies. Overall, improvements following treatment with DBT extended over the follow-up period. These findings suggest that the effects of DBT in treating BPD are maintained at least 1 to 2 years postintervention. Given a lack of long-term follow-up in randomized controlled trials, evidence for the efficacy of DBT in the longer term is unclear.
The Glocalization of Esotericism
Authors: Sedgwick Mark
Published: August 2022

This article traces the history of the South American reception of the work of the esoteric philosophers René Guénon and Julius Evola, and of the Maryami Sufi Order of Frithjof Schuon, focusing on Argentina, Brazil, Chile, and Peru. It compares South American forms of Traditionalism with those found elsewhere, primarily in Europe and North America, understanding differences between these in terms of “glocalization,” the local adaptation of the global. Traditionalism in South America was most localized in its religio-political form, which was more important for the Right in South America than elsewhere, and least localized in its purely religious form, which was less significant in South America than elsewhere. The impact of Traditionalism in South American academia, notably in philosophy and anthropology, also reflects local conditions, as does an unusual interest in indigenous peoples.
Impact of the Waco Branch Davidian Case and the Anticult Movement in Post-Communist Hungary
Authors: Fazekas Csaba
Published: August 2022

This article examines the ways Hungarian political life and public debate were influenced by the news media’s coverage of the 1993 conflict involving the Branch Davidians living at Mount Carmel Center near Waco, Texas and United States federal agents, in which a total of eighty-six people were killed. After the collapse of the Soviet political system, new religious movements began spreading rapidly in Eastern European nations at the beginning of the 1990s. The first anticult movements in Hungary were closely connected to the political conservativism and traditional religiosity represented by so-called “historical” Christian churches. The conservative governing parties aimed to restrict new religious movements by withdrawing financial support and by enacting a new law on religion and denominations resulting in anticult propaganda disseminated by the state. The news about the conflict and deaths at Mount Carmel Center played an important catalyzing role in the anticult parliamentary and press debates in Hungary. The tragedy of the deaths at Mount Carmel became one of the most important arguments in the hands of politicians in Hungary who wanted to limit freedom of religion for members of new religious movements.
Moving Past Crowleyism
Authors: Wilson Ian S.
Published: August 2022

Aleister Crowley is one of the most famous esotericists of the twentieth century. His religion, Thelema, is still practiced today. His acolytes, however, have not been given equal or equitable historical representation. When they are included, they are generally secondary—regarded as followers of Crowley, rather than of Crowley’s religion. This article argues that acolytes were more important in the development and organization of Thelema than they have been portrayed. Through the story of Hollywood actress turned Thelemite Jane Wolfe, based on her diaries written at Cefalù, Italy, Crowley is shown to be dreamy and distracted, while Wolfe was focused and expressed agency within the structure of Crowley’s religion. Wolfe’s discipleship provides a new and different lens through which to study Thelema, and demonstrates that Thelema can and does exist separately from Crowley.
Ex vivo reconstitution of fetal oocyte development in humans and cynomolgus monkeys
Authors: Mizuta Ken , Katou Yoshitaka , Nakakita Baku , Kishine Aoi , Nosaka Yoshiaki , Saito Saki , Iwatani Chizuru , Tsuchiya Hideaki , Kawamoto Ikuo , Nakaya Masataka , Tsukiyama Tomoyuki , Nagano Masahiro , Kojima Yoji , Nakamura Tomonori , Yabuta Yukihiro , Horie Akihito , Mandai Masaki , Ohta Hiroshi , Saitou Mitinori
Published: August 2022

In vitro oogenesis is key to elucidating the mechanism of human female germ‐cell development and its anomalies. Accordingly, pluripotent stem cells have been induced into primordial germ cell‐like cells and into oogonia with epigenetic reprogramming, yet further reconstitutions remain a challenge. Here, we demonstrate ex vivo reconstitution of fetal oocyte development in both humans and cynomolgus monkeys (Macaca fascicularis). With an optimized culture of fetal ovary reaggregates over three months, human and monkey oogonia enter and complete the first meiotic prophase to differentiate into diplotene oocytes that form primordial follicles, the source for oogenesis in adults. The cytological and transcriptomic progressions of fetal oocyte development in vitro closely recapitulate those in vivo. A comparison of single‐cell transcriptomes among humans, monkeys, and mice unravels primate‐specific and conserved programs driving fetal oocyte development, the former including a distinct transcriptomic transformation upon oogonia‐to‐oocyte transition and the latter including two active X chromosomes with little X‐chromosome upregulation. Our study provides a critical step forward for realizing human in vitro oogenesis and uncovers salient characteristics of fetal oocyte development in primates.
The mystery of mitochondrial plasticity: TMBIM5 integrates metabolic state and proteostasis
Authors: Ren Mindong , Schlame Michael
Published: August 2022

How cellular cues alter the mitochondrial proteome and impact the composition of mitochondrial proteins remains poorly understood. In this issue of The EMBO Journal, Patron et al (2022) identify TMBIM5 as an important link between calcium homeostasis, proton motive force, and mitochondrial proteolysis, by which the organelle can modify its protein composition. The results may be crucial for our understanding of the plasticity of mitochondria.
Os limites da definição de Budismo em Émile Durkheim: uma análise das Quatro Nobres Verdades
Authors: França Nirvana Oliveira Moraes Galvão , Beluzzi Ethel Panitsa
Published: August 2022

Émile Durkheim, em seu As Formas Elementares da Vida Religiosa, cita como o pilar da filosofia e da religião budista as Quatro Nobres Verdades – um referencial teórico que permeia o desenvolvimento de todas as principais tradições de pensamento budistas. Neste artigo, nosso objetivo é apresentar linhas gerais e introdutórias sobre esse conceito tendo como linha narrativa o texto de Durkheim – trazendo, também, discussões sobre os contextos onde Durkheim escreveu e contrapondo outras abordagens teóricas.
ICP-spectrometric determination of the total tin content in the water of the Azov and Black seas using the hydride generation technique
Authors:   Kuban State University, Temerdashev Z. A. , Abakumov P. G. ,   Kuban State University, Abakumova D. D. ,   Kuban State University
Published: August 2022

The current paper considers the possibility of determining the total tin content in the waters of the Azov and Black seas using the hydride generation technique. The conditions for the generation of tin hydrides were optimized for the subsequent determination by inductively coupled plasma atomic emission spectrometry (ICP-AES) and inductively coupled plasma mass spectrometry (ICP-MS). When studying the matrix effect of the components, it was found that the transition metals Ni2+, Co2+, Cu2+, and Fe3+ reduce the analytical signal of tin. The possibility of leveling the influence of transition metals by various binding masking agents (L-cysteine, EDTA, tartaric acid, potassium iodide and thiocarbamide), of which L-cysteine showed the greatest efficiency, was studied. Under the optimized analysis conditions, the limits for the determination of inorganic tin in the model waters were established, which, regardless of the salinity level, were 0.05 and 0.03 μg/dm3 for ICP-AES and ICP-MS, respectively. The possibility of determining tin in waters using the hydride generation technique, when the analyte was present in the form of organotin compounds, was evaluated. It has been shown that for the ICP spectrometric determination of the analyte with the generation of hydrides in water containing organotin compounds, microwave mineralization of the samples was required. The satisfactory convergence of the analyses’ results was observed when determining the total content of tin in sea waters in the concentration ranges of 0.05–2.00 and 0.03–2.00 μg/dm3 for ICP-AES and ICP-MS, respectively. The developed methods were used to determine tin in the waters of the Azov and Black seas; the total analyte content in them was 0.15 and 0.23 μg/dm3­, respectively.
Electrochemical sensor modified with gold and arenediazonium salts for the determination of copper and mercury in human’s hair
Authors:   National Research Tomsk Polytechnic University, Slepchenko G. B. , Ostapenko M. S. ,   National Research Tomsk Polytechnic University, Akeneev Yu. A. ,   National Research Tomsk Polytechnic University, Moiseeva E. S. ,   National Research Tomsk Polytechnic University
Published: August 2022

Current article presents the results of using a solid carbon-containing electrochemical sensor modified with arenediazonium salts (ME-ADT-COOH) for the joint determination of copper and mercury in human hair. The sensitivity of the determination of copper and mercury ions using a graphite electrode modified with gold and arenediazonium salts with a substituent carboxy group is higher compared to the other carbon-containing modified electrodes. The influence of the concentration of arenediazonium tosylates with various substituents on the obtained analytical signal was studied. The conditions for the manufacturing the new carbon-containing modified electrochemical sensor have been developed. The effective surface area of the modified electrode was calculated, which was estimated using a cyclic voltammogram against the background of 0.1 M KCl with the addition of potassium hexacyanoferrate (С=5*10-4mol/l) salts and calculated using the Randles-Ševčík equation for the reversible electrode process. A linear range of determined concentrations in the voltametric determination of microelements on the arendiazonium-modified gold-graphite electrode was established - from 0.1 to 12 µg/g. The error of the determination did not exceed 25 %. The correctness of the results of the determination of copper and mercury in real objects by the “introduced-found” method, which correlates well with the known values, has been verified.
Book review for “X-Ray Fluorescence in Biological Sciences: Principles, Instrumentation, and Applications”, Eds: V.K. Singh, J. Kawai, D.K. Tripathi. Wiley. 2022, 688 pp. ISBN: 978-1-119-64554-2A
Authors:   Institute of the Earth’s Crust, SB RAS, Revenko A. G.
Published: August 2022

Through the efforts of three editors - V.K. Singh and D.K. Tripathi (India), and J. Kawai (Japan), as well as 79 qualified specialists from 14 countries, “X-ray Fluorescence in Biological Sciences: Principles, Instrumentation and Applications” monograph was prepared and published in March of this year. The book is divided into six parts. Part 1 is a general introduction to RFA (7 chapters). Parts 2 and 3 are relatively new versions of the XRF method using the synchrotron radiation for the excitation of fluorescence (5 chapters) and XRF with total external reflection (4 chapters). Part 4, a beginner's guide, is considered by the editors to be one of the highlights of this book (4 chapters). The main parts of this book are Parts 5 (Application for Biological Samples - 11 chapters) and 6 (Special Topics and Comparison with Other Methods - 8 chapters). The book provides information on advances in the application of X-ray fluorescence analysis that have not been reflected in general monographs published in recent years. Representatives of India prepared 15 chapters, colleagues from Russia – 7, from Mongolia and China – 3 each, Japan, Spain, Turkey and Slovenia – with 2 chapters each, Italy, Argentina, and Bangladesh – 1 each. Representatives of Algeria and Egypt co-authored with colleagues from Turkey, and of South Korea with colleagues from India, respectively. The largest number of participants (authors of chapters) – 29 – was noted for India, 11 – from Russia, and 6 each from China, Turkey, and Slovenia. The monograph will be in demand in the laboratories of universities and research institutes, especially in the laboratories of biological and medical research centers. It will be a useful guide for students of natural and chemical sciences, medical biology, plant physiology, and agriculture.
Monkeypox: o que estamos esperando para agir?
Authors: Boing Alexandra Crispim , Donalísio Maria Rita , Araújo Tânia Maria de , Muraro Ana Paula , Orellana Jesem Douglas Yamall , Maciel Ethel Leonor , Associação Brasileira de Saúde Coletiva (ABRASCO) Comissão de Epidemiologia da
Published: August 2022

N/A
A modified applied element model for the simulation of plain concrete behaviour
Authors: Soysal Berat Feyza , Arici Yalin , Tuncay Kagan
Published: August 2022

A modified applied element model to simulate the behaviour of plain concrete continuum structures including discrete cracking is proposed in this study. In the classical applied element model, Poisson effects are fully ignored. To remediate this issue, diagonal elements are introduced to include the Poisson effect, and the constitutive parameters are rigorously determined using the Cauchy–Born rule and the hyper-elastic theory. The formulation is validated for linear elastic problems and the consistency and convergence behaviour of the numerical approach is shown. Tensile softening formulation using the concept of fracture energy is utilised for the nonlinear range. In this range, the approach is validated using the classical benchmark tests with pure tensile, split-tensile, combined shear-tensile and bending dominated push-over loading. The load–displacement behaviour and crack response were captured successfully, showing the proposed methodology can be used to quantify discrete cracks on large systems, such as dam monoliths, from initiation to significant damage levels.
Educational value of spinal injection therapy videos in Korean YouTube for back pain patients
Authors: Kim Soo Bin , Cho Seung Bae , Choi Hyogyun , Lim Sehun
Published: August 2022

Background: YouTube, the largest online video platform, has become increasingly popular as a source of health information to patients. The aim of the study was to assess whether Korean patients were well informed about spinal injection from YouTube.Methods: Search for the keyword “cheog-chu ju-sa” in Korean language was done, and the quality of the 51 videos with the highest number of views was evaluated independently by two pain management doctors.Results: The averages of global quality scores evaluated by the two doctors were 3.0 and 3.5 and modified DISCERN (mDISCERN) scores were 2.8 and 3.0, respectively. The Kappa statistic between the two doctors’ scores was 0.285 and 0.417.Conclusions: The percentage of low-quality videos with a global quality score of 2 or less is 18–36%, which indicated that these videos might provide inaccurate or misleading medical information to the patient. Pain clinic doctors should be wary of medically misleading information available on online platforms, such as YouTube, and strive to create and distribute professional quality educational materials.
[RETRACTED] Apple Keto Gummies Australia Reviews Diet Pills v1
Authors: Keto Gummies Apple
Published: August 2022

[RETRACTED]

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[RETRACTED] Instant keto reviews does it really work? v1
Authors: Keto Instant
Published: August 2022

[RETRACTED]

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Mito-Keima assay to assess mitophagy v1
Authors: Ngoc Nguyen Thanh
Published: August 2022

This protocol details the procedure of mito-keima assay to assess mitophagy.
Preparation of Bacteria Glycerol Stocks v2
Authors: Fadanka Stephane
Published: August 2022

This protocol is meant to provide researchers with a step by step procedure on how to prepare glycerol stocks in order to preserve and store bacteria for long term. Bacterial glycerol stocks are important for long-term storage of plasmids. The addition of glycerol stabilizes the frozen bacteria, preventing damage to the cell membranes and keeping the cells alive. A glycerol stock of bacteria can be stored stably at -80°C for many years and -20°C for several months. Glycerol reduces the harmful effects of ice crystals on bacteria which cause dehydration and damage cells through a localised increase in salt concentration leading to the denaturation of proteins.
From Neurodidactics to Language Teaching and Learning: The Emotional Approach
Authors: Lucas-Oliva Inés , Toledo-Vega Gloria , Núñez-Román Francisco
Published: August 2022

The latest findings in Neurodidactics in understanding learning processes are forcing a review of the methodological approaches underlying teaching practices, including those used in second language teaching. Therefore, drawing on the principles of Neuroscience, Didactics and Linguistics, a review of the central factors of language learning and acquisition is carried out. A new methodological approach to foreign language teaching based on emotions is proposed: the Emotional Approach. Next, the principles of the Emotional Approach are presented, and its most relevant theoretical and practical contributions are highlighted. These include the functioning of neural connections in second language learning and the critical role played by emotions in the teaching-learning processes. Finally, this study provides the theoretical bases necessary to elaborate future didactic proposals and experimental research on the postulates presented here. Implications for research and practice are also discussed.
Rapid clinical progression of stage III-IV oral and oropharyngeal cancer after upfront surgery and difficulty in the assessment of the effectiveness of adjuvant radiotherapy
Authors: Karpenko A. V. , Sibgatullin R. R. , Boyko A. A. , Nikolayeva O. M.
Published: August 2022

Introduction. Surgery with adjuvant radiation is the standard for treatment of advanced oral and oropharyngeal cancer. with the absence of randomized trials the assessment of the role of postoperative radiotherapy is difficult. Such assessments are usually based on retrospective analyses, whereas patient and tumor status during the time period between the operation and planned start of radiotherapy is not addressed.

The study objective is to assess the role of adjuvant radiotherapy in the treatment of stage III—IV oral and oropharyngeal cancer not associated with human papillomavirus with regard to rapid clinical disease progression after upfront surgical treatment.

Materials and methods. The case histories and outpatient records of 260 patients with oral and oropharyngeal cancer of stage III—IV, not associated with human papillomavirus, from 30 to 82 years old (average age - 56.52 years), operated in 2009-2018, were analyzed. Two groups of patients were identified. group 1 included 152 patients (58 %) irradiated postoperatively and group 2 consisted of 108 patients (42 %) treated surgically only. 22 patients of group 2 experienced rapid clinical disease progression, were deemed unsuitable for adjuvant treatment and formed group 2a. Comparison of the Kaplan-Meier overall survival and locoregional control was made for group 1 and the entire group 2 (formal analysis) and after exclusion from the latter patients of group 2a, based on the hypothesis of inability of radiotherapy to improve oncologic results in patients with such an unfavorable disease course.

Results. Mean follow up was 33.2 months (range 2-121 months). Locoregional control and 5 year overall survival were statistically higher in group 1: 70.4 % versus 45.4 % (р = 0.000) and 40.2 % versus 24.9 % (р = 0.000) that may imply a significant advantage of the combined over monomodal approach. After exclusion of group 2a patients from the analysis both differences considerably narrowed and were 70.4 % versus 55.8 % for locoregional control, 40.2 % versus 31.3 % for overall survival and became statistically insignificant (p = 0.067 and 0.111, respectively).

Conclusion. Rapid clinical disease progression in the time frame between surgical treatment and adjuvant radiotherapy is not a rare phenomenon with a very poor prognosis. It can be one of the reasons for postoperative treatment refusal. formal retrospective analyses of the role of adjuvant treatment without considering causes for its refusal may lead to the overestimation of the combined approach effectiveness.
POLITIZATION OF HISTORY AND ITS ROLE ON THE INTERNATIONAL RELATIONS: THEORETICAL AND EMPIRICAL ANALYSIS ON EXAMPLE OF POLISH-GERMAN RELATIONS
Authors:   Taras Shevchenko National University of Kyiv, Stetsiuk N. M. , Boichuk O. I. ,   Taras Shevchenko National University of Kyiv, Strutynska T. Z. ,   Taras Shevchenko National University of Kyiv
Published: August 2022

Development of bilateral relations between States is a complex and multifaceted process. There are many factors to affect the quality, and sometimes-quantitative characteristics of the relationship. For example: economic feasibility (bilateral patterns of trade, economic interest in partners, and level of investment attractiveness), political expediency (to what extent the partner country is of interest to political elites or the public), image of the country within society, cultural cooperation level. To the above list, which is by no means exhaustive, historical memory should be added. Historical memory of yourself and partner's country, or how this term is articulated within a given society.
INFLUENCE OF DIFFERENT US POPULATION STRATUM ON 2020 PRESIDENTIAL ELECTION
Authors:   Taras Shevchenko National University of Kyiv, Nanavov A. S. , Ruban A. A. ,   Taras Shevchenko National University of Kyiv
Published: August 2022

In today's world, fair and free elections are the key to democracy. They play an integral role in the peaceful transfer of power. By casting their votes, the people elect leaders on whom the future of society depends. That is why the elections give great power to ordinary citizens: voting gives the opportunity to influence the policies of the future government, and hence their future destiny. When the founding fathers of the United States drafted and ratified the country's constitution, they did not give any role to political parties. In fact, through various constitutional mechanisms, such as the separation of powers between the executive, legislature, and judiciary, the federal system, and the indirect election of the president by a electoral college, they sought to protect the new republic from party and factional influence. Despite the Founding Fathers, in 1800 the United States became the first nation to establish permanent political parties organized on a nationwide basis to ensure the transfer of executive power from one faction to another on the basis of elections. the development and expansion of political parties was closely linked to the expansion of suffrage.
Contribution to the Molybdenum Blue Reaction and its Application in Soil Analysi
Authors:   University of Chemical Technology and Metallurgy, Department of Analytical Chemistry, Bulgaria, Angelova Lyudmila , Genova Nezabravka ,   University of Chemical Technology and Metallurgy, Department of Analytical Chemistry, Bulgaria, Pencheva Gergina ,   University of Chemical Technology and Metallurgy, Department of Analytical Chemistry, Bulgaria, Statkova Yasena ,   University of Chemical Technology and Metallurgy, Department of Analytical Chemistry, Bulgaria, Yotova Violeta ,   University of Chemical Technology and Metallurgy, Department of Analytical Chemistry, Bulgaria, Surleva Andriana ,   University of Chemical Technology and Metallurgy, Department of Analytical Chemistry, Bulgaria
Published: August 2022

This paper presents a study on the molybdenum blue reaction (MB) as a finishing detection step in soil analysis for quantification of plant available phosphorus. An ammonium acetate/calcium lactate reagent (pH = 4.2) was used for soil phosphorus extraction. The molybdenum blue color reaction using premixed Murphy-Riley reagent and ascorbic acid as a reductant was reinvestigated. UV-Vis characteristics of MB, optimal wavelength, reaction time and concentration of reductant were studied. The effect of ascorbic acid concentration and the reaction time on linearity, bias and uncertainty was discussed. The molybdenum blue reaction was found to obey Beer’s law in the targeted concentration range of 0.04 – 1.0 mg L-1 PO43- - P. The linearity was proved by “lack-of-fit” test. The uncertainty budget was made and the uncertainty was estimated by modelling approach, as well as single laboratory and quality control approach. The recovery and the expanded uncertainty were found to be, respectively, (95.7 ± 8.7) % (P = 95 %, n = 3) and 9.2 mg PO43- - P/kg dry soil (k = 2). The results showed that the soil sample inhomogeneity and the repeatability of extraction process were the main factors which contribute to the uncertainty of measurement in soil analysis.
Analysis of Concept of Big Data Process, Strategies, Adoption and Implementation
Authors: Chaudhary Dr. Sunita
Published: August 2022

Big data is the data set which contains variety of data which increases on a daily basis in an organisation and also it has large volume of data with high velocity. It is the complex form of data which is usually identified from new set of data sources. It is widely used in most of the companies as it will have latest data which is useful to solve critical issues in the business or an organisation. BIG data has such large volume of data that it cannot be handled by simple data handling software and need latest technology software to handle such large volumes of data. The amount of data present in big data is so complex and large in volume that it needs skilled professionals to manage the data and requires efficient efforts to maintain it. Small businesses cannot afford to implement BIG data in their business due to its complex nature and also the cost factor is higher as compared to traditional data software. The paper will explain the various categories of big data, its importance, strategies and implementation process.
Modified Generalized R/T Coefficient Method for Surface-Wave Dispersion-Curve Calculation in Elastic and Viscoelastic Media
Authors: Pan Lei , Yuan Shichuan , Chen Xiaofei
Published: August 2022

This article presents an efficient and effective modified generalized reflection and transmission (R/T) (mGRT) coefficient method for dispersion-curve calculation of the Rayleigh and Love waves. We construct a novel dispersion function based on the kernel function for calculating synthetic seismograms in an elastic layered half-space model. It improves the root searching using the monotonicity of the dispersion function in sections between roots. We introduce an auxiliary function to accelerate the root-searching procedure by approximating the number of roots of the dispersion equation. To solve the low-velocity-layer problem for the generalized R/T coefficient method, we turn to the dispersion function of multiple depths. Numerical results indicate that the proposed method is slightly slower than the other most efficient methods including the delta-matrix method and the fast delta-matrix method. Then, we present a technique for the velocity and attenuation dispersion curves in viscoelastic media. The technique is based on jumping features of the dispersion function and converts 2D root-searching problem to 1D minimization problem. The mGRT method is expected to be a useful candidate for calculating dispersion curves in both elastic and viscoelastic media.
A Nonergodic Ground Motion Model for Chile
Authors: Macedo Jorge , Liu Chenying
Published: August 2022

In this study, we develop a new nonergodic ground motion model (GMM) for Chile, which better captures the trade-off between the aleatory variability and epistemic uncertainty on ground motion estimates compared with existing GMMs. The GMM is developed for peak ground acceleration and pseudospectral acceleration at a period of 1 s. Most existing GMMs for subduction earthquake zones were developed based on an ergodic assumption, and this is not the exception for the subduction zone in Chile. Under the ergodic assumption, the ground motion variability at a given single site–source combination is considered the same as the variability observed in a global database. However, recent efforts have highlighted significant location-specific systematic and repeatable effects for ground motions recorded within a particular region. These systematic effects promote the relaxation of the ergodic assumption and the transition to the development of nonergodic GMMs. The nonergodic GMM developed in this study uses an ergodic GMM as a backbone, the systematic source and site effects are modeled using Gaussian processes, and the path effects are modeled using the cell-specific attenuation approach enhanced with a computer graphics-based algorithm. The coefficients of the nonergodic GMM are estimated using Bayesian inference via Markov chain Monte Carlo (MCMC) methods, in which we use an integrated nested Laplace approximation approach to address the computational burden involved in MCMC. The developed nonergodic GMM reveals spatially varying and correlated location-specific source, path, and site effects in Chile, which cannot be captured by existing Chilean ergodic GMMs. Moreover, the developed nonergodic GMM shows a reduced aleatory variability compared to existing ergodic GMMs that are commonly used in Chile. In addition, the developed nonergodic GMM shows small epistemic uncertainty for regions with large ground motion data and large epistemic uncertainty for regions with few ground motion data. Finally, we provide guidelines on how to use the developed nonergodic GMM in the context of probabilistic seismic hazard analysis, which is important for performance-based earthquake engineering assessments in Chile.
The Effect of Osaka Mutation on Oligomer Formation of Full-Length Amyloid [beta]-Protein Oligomers
Authors:   , Shah Riya , Urbanc Brigita
Published: August 2022

Alzheimer's disease (AD) is the leading cause of dementia among the elderly and is characterized by loss of memory due to neuronal death. In vitro and in vivo experiments have identified soluble, low-molecular weight, non-covalently bonded oligomeric forms of amyloid [beta]-protein (A) as the likely toxic species that leads to AD. The Osaka mutation ([E22[delta]]), discovered in a Japanese family, is associated with an early-onset AD in the carriers of this mutation, and involves a deletion of the glutamic acid at the twenty-second position in A[beta]. A[beta] with Osaka mutation can be used to probe the effect of singular deletions on oligomerization and protein conformations. We use discrete molecular dynamics (DMD) simulations with a four-bead protein model and implicit solvent to study the oligomerization of the two most predominant alloforms, A[beta]1-40 and A[beta]1-42, and their Osaka mutants. Our findings suggest that the Osaka mutation alters A[beta]1-40 structure and assembly mechanics to be more similar to A[beta]1-42 and [E22[delta]]A[beta]1-42. Specifically, the Osaka mutation greatly affects the secondary structure of A[beta]1-40 in the N-terminal region to make it resemble A[beta]1-42. We also show that [E22[delta]]A[beta]1-40 and [E22[delta]]A[beta]1-42 tend to assemble into larger oligomers than their wild-type (WT) counterparts and that both mutants are more prone than wild type A[beta] to forming a tertiary contact between D23 and K28. The proximity of negatively charged D23 and positively charged K28 is expected to induce an intrapeptide salt bridge, stabilization of which is known for speeding up fibril formation. These results provide a plausible explanation of why Osaka mutants aggregate into fibrils much faster than WT peptides. The early-onset properties of the Osaka mutation might be attributed to the resemblance of [E22[delta]]A[beta]1-40 oligomer conformations to those formed by A[beta]1-42, specifically the property of A[beta]1-42 possessing disordered and solvent accessible N-termini, which would readily interact with and potentially disrupt cellular membranes.
The Impact of Aging on Antiviral Pathways and Immune Functions
Authors:   , Connors Jennifer Rebecca , Nonnemacher Michael R.
Published: August 2022

As global populations shift into higher age demographics there is a significant global public health challenge caused by increased morbidity and mortality associated with age. These aging associated morbidities and mortalities can be partially attributed to a condition of chronically enhanced basal inflammatory levels and immune system dysregulation known as immunosenescence. This phenomenon is suspected to decrease vaccine efficacy and natural immunity against multiple infections including coronavirus disease of 2019 (COVID-19). It is well documented that older individuals have severe COVID-19 complications including pneumonia, respiratory failure, or acute respiratory distress syndrome (ARDS). We have previously demonstrated older donors have delayed and defective induction of type I interferons, T-cell and B-cell helper cytokines in response to TLR/RLR ligands when compared to those from younger adult subjects. However, the underlying intracellular mechanisms defining these defects are not well described. We investigated these impairments in the aging immune system within the context of COVID- 19 vaccination status and COVID-19 infection. We hypothesized that the anti-viral signaling alterations that we observe in healthy older individuals have lasting impacts on how they respond to mRNA vaccination, and SARS-CoV-2 infection. We show that type I IFN production, including the phosphorylation of IRF7 and TBK-1 in the TLR 7/8, RIG-I or cGAS-STING pathways and phagocytosis is dysregulated in innate immune cells (i.e., cDC1s, cDC2s, and CD14dimCD16+ monocytes) from healthy aged individuals (>65yrs old). Anti-viral signaling deficits are also highlighted after application of lipid nanoparticles that are devoid of mRNA (eLNP). Accordingly, application of eLNP resulted in maturation and activation of monocytes and dendritic cells as well as increased phagocytosis. Germinal center dendritic cells (cDC2) display altered anti-inflammatory capacity characterized by increased frequency of PD-L1 and production of TGF-B2 and TGF-B3 when treated with eLNP, suggesting eLNP-mediated immunomodulation is differential across age groups. These findings have been expanded upon in a COVID-19 cohort to similar affect. Taken together, these studies and results discussed herein highlight the importance of antiviral target identification that is considerate of immunosenescent defects and subsequently will enhance vaccine induced immune responses in >65 individuals.
The role of serum-derived small extracellular vesicles in pain
Authors:   , Lin Zhucheng , Ajit Seena
Published: August 2022

Chronic pain is a significant public health issue. Current treatments have limited efficacy and significant side effects, warranting research on alternative strategies for pain management. One approach involves using small extracellular vesicles (sEVs) to transport beneficial biomolecular cargo to aid pain resolution. We hypothesized that sEVs could impact the development of pain hypersensitivity in recipient mice. We investigated the role of serum-derived sEVs isolated from naïve or spared nerve injury (SNI) model mice. Dose response studies in naïve recipient mice show intrathecal injection of sEVs 1) transiently increased basal mechanical thresholds, 2) accelerated recovery from complete Freund's adjuvant induced inflammatory pain, and 3) delayed the development of neuropathic pain in SNI model mice. LC-MS-MS studies showed sEVs contained endogenous opioid peptides leu-enkephalin and nociceptin. Transient analgesia induced by sEVs was reversed by the opioid antagonist naltrexone, suggesting that leu-enkephalin in sEVs contributes to a short-term analgesic effect. miRNA profiling of sEVs from naïve and SNI model mice showed unique and overlapping signatures. miR-339-3p was one of the highly expressed miRNAs in both sEVs. We confirmed miR-339-3p can downregulate annexin A3 (ANXA3), a protein upregulated by microglia in neuropathic pain models. Uptake of sEVs decreased ANXA3 leading to inhibition of NF-kB activity suggesting miR-339-3p-ANXA3-NFkB axis could help attenuate pain and inflammation. Further, when cortical neuron-glia microelectrode array cultures were treated with sEVs, we observed reduced synchronous network activity demonstrating a modulatory role for sEVs in neuronal networks. Collectively, these studies demonstrate multiple mechanisms by which sEVs can attenuate pain.
Uncovering a novel regulatory mechanism for casein kinase 2 (CK2)
Authors:   , Chojnowski John Edmund , Strochlic Todd I
Published: August 2022

CK2 is an evolutionarily conserved serine/threonine kinase implicated in a wide range of cellular functions and known to be dysregulated in various diseases such as cancer. Compared to most other kinases, CK2 exhibits several unusual properties, including dual co-substrate specificity and a high degree of promiscuity with hundreds of substrates described to date. Perhaps most paradoxical, however, is its apparent constitutive activity: no definitive mode of catalytic regulation has thus far been identified. Here we demonstrate that copper enhances the enzymatic activity of CK2 both in vitro and in cells. We show that copper binds directly to CK2 and identify specific residues in the catalytic subunit of the enzyme that are critical for copper-binding. We further demonstrate that increased levels of intracellular copper result in enhanced CK2 kinase activity, while decreased copper import results in reduced CK2 activity. Taken together, these findings establish CK2 as a copper-regulated kinase and indicate that copper is a key modulator of CK2-dependent signaling pathways.
PSYCHOLOGICAL CAPITAL LEVEL OF AIRPORT EMPLOYEES AND THE RELATIONSHIP BETWEEN WORKPLACE HAPPINESS
Authors: ANNAÇ GÖV Sabiha , GÜN Selinnur
Published: August 2022

The concept of psychological capital is used for purposes such as ensuring sustainability and gaining competitive advantage for businesses. The first aim of the study is to determine the relationship between the level of psychological capital and workplace happiness level of employees at the airport. The second aim is to reveal whether there is an effect of psychological capital level on workplace happiness level. The third aim is revealing whether there are differences between mean of psychological capital according to demographic characteristics. In the study, the relationship between the psychological capital level of the participants and workplace happiness, how they vary according to age, gender, marital status, educational status, seniority in the workplace and occupation characteristics were explained statistically. As a result, the relationship between the psychological capital level and workplace happiness was determined. Also, the effect of psychological capital level on workplace happiness level was found. It will contribute to the literature as the first study on this subject for airport personnel in Turkey.
FARKLI BİLİM ALANLARINDA ÇALIŞAN ÖĞRETİM ELEMANLARININ SAĞLIKLI YAŞAM BİÇİMİ DAVRANIŞLARI İLE YAŞAM KALİTELERİ ARASINDAKİ İLİŞKİNİN İNCELENMESİ
Authors: TURAN KURTARAN Ayten , SEVİM Ferit , ERDEN Arzu
Published: August 2022

Çalışmanın amacı, farklı bilim alanlarında çalışan öğretim elemanlarının sağlıklı yaşam biçimi davranışlarını ve yaşam kalitelerini araştırmaktır. Çalışmaya Karadeniz Teknik Üniversitesi'nde görev yapan 491 (Kadın: 256/ Erkek: 235) akademik personel dahil edildi. Çalışmada “Sağlıklı Yaşam Biçimi Davranışları Ölçeği (SYBD) II” ve “Hastalık Kontrol Merkezi Sağlıkla İlgili Yaşam Kalitesi Anketi (CDC-HRQOL-4)” kullanıldı. SYBD alt boyutları ile yaşam kalitesi (YK) arasındaki ilişki yatay kesit çoklu regresyon analizi yöntemiyle incelendi. Analiz sonuçlarına göre, manevi gelişim, kişilerarası ilişkiler ve stres yönetimi alt boyutlarında sağlık bilimleri alanında çalışan öğretim elemanları diğer bilim alanlarında çalışanlardan daha iyi düzeyde SYBD’ye sahipti (p=0,007, p=0.008, p=0.028). Fen bilimleri alanında çalışanların YK ruhsal sağlık skorları, diğer bilim alanlarında çalışanlardan daha iyi düzeyde idi (p=0,026). SYBD alt boyutlarında sağlık bilimleri ile sosyal bilimler arasında manevi gelişimde (p=0,006), sağlık bilimleri ile fen bilimleri arasında stres yönetimi (p=0,023) ve kişilerarası ilişkilerde (p=0,034) anlamlı ilişki vardı. Çalışma, sağlık bilimleri alanında görev yapan öğretim elemanlarının diğer bilim alanlarına göre daha yüksek düzeyde SYBD’ye ve fen bilimlerindekilerin daha yüksek YK’ye sahip olduğunu ortaya koydu.
ENFLASYON, ENFLASYON OYNAKLIĞI VE VERGİ GELİRLERİ ARASINDAKİ DİNAMİK İLİŞKİLER: TÜRKİYE ÖRNEĞİ
Authors: KOÇAK Sinem , KARIŞ Çiğdem , ÇİL Dilek
Published: August 2022

Monetarist görüş enflasyonu parasal bir olgu olarak görmektedir. Bu bağlamda, enflasyonun para arzındaki aşırı artıştan kaynaklandığı ileri sürülmektedir. Yarattığı belirsizlik ortamıyla enflasyon, başta ekonomik büyüme olmak üzere ekonomiyi çeşitli kanallar aracılığıyla olumsuz etkileyebilmektedir. Yüksek enflasyonun ekonomide meydana getirdiği olumsuz etkilerdin birisi enflasyon oynaklığıdır. Enflasyon oynaklığı yüksek enflasyonla yakından ilişkilidir. Enflasyon oynaklığı geleceğe yönelik fiyat beklentilerini daha belirsiz hale getirmek suretiyle ekonomik belirsizliği artırabilmektedir. Bu çalışmanın amacı enflasyon, enflasyon oynaklığı ve vergi gelirleri arasındaki ilişkileri Johansen ve Juselius eşbütünleşme testi ve Vektör Otoregresif (VAR) modeli kullanarak araştırmaktır. Türkiye ekonomisi için 1965-2019 döneminin dikkate alındığı çalışmada yıllık veri setinden yararlanılmıştır. Ekonometrik analizin ilk aşamasında enflasyon oynaklığı EGARCH yönteminden elde edilen koşullu varyans serisi ile ölçülmüş, hemen akabinde değişkenlerin durağanlık özellikleri Augmented Dickey-Fuller (ADF) ve Philips-Perron (PP) birim kök testleri aracılığıyla incelenmiştir. Değişkenlerin durağanlık seviyeleri dikkate alınarak oluşturulan VAR modelinden elde edilen sonuçlar çok büyük ölçüde enflasyon oranından kaynaklanan enflasyon oynaklığının vergi gelirleri üzerinde etkisi olduğunu ortaya koymaktadır.
THE TWIN DEFICITS OR NEGATIVE REVERSE CAUSALITY? A NONLINEAR APPROACH TO THE TURKISH BUDGET AND CURRENT ACCOUNT BALANCES
Authors: TELATAR Osman Murat
Published: August 2022

The budget deficit causing an increase in the current account deficit is named twin deficits. In addition, the budget and current account balances represent the internal and external balance of the economy. As in many developed and developing countries, revealing the relationship between internal and external imbalances in the Turkish economy in terms of determining economic policies is very important. Most of the studies on twin deficits in the literature are based on analyzes with linear models. The aim of this study, unlike other studies in the literature, is to examine the relationship between the budget and current account balance in the Turkish economy with non-linear time series analysis. For this purpose, nonlinear unit root and cointegration tests were applied to the data covering the period 1994-2021. The findings show that the negative reverse causality hypothesis is valid instead of the twin deficits hypothesis in the Turkish economy in the analyzed period. Accordingly, there is a negative relationship from the current account balance to the budget balance in both the long and short run.