bluuebunny/crossref_metadata_2025 huggingface dataset:
Stock Movement Prediction Using Machine Learning Based on Technical Indicators and Google Trend Searches in Thailand
Authors: Saetia Kittipob , Yokrattanasak Jiraphat
Published: December 2022

Machine learning for stock market prediction has recently been popular for identifying stock selection strategies and providing market insights. In this study, we adopted machine learning algorithms to analyze technical indicators, and Google Trends search terms based on the Thai stock market. This study uses three datasets, which are technical indicators, Google Trends search terms, and a combination of the two. The objectives were to study and identify the factors in stock selection, develop and evaluate portfolio selection models using keyword proxies from the three datasets mentioned, and compare the performance of the selected algorithms. In the prediction process, we discovered that the combination of technical indicators and Google Trends search terms while applying Logistic Regression, Random Forest, and Extreme Gradient Boosting (XGBoost) exhibited the highest ROC curves. For success prediction rate and annualized return, Random Forest and XGBoost were almost similar but still different. While XGBoost performs well during a period of market critical conditions (COVID-19), Random Forest performs marginally better than XGBoost during normal market conditions in terms of average success rate.
Toward 3D Property Valuation—A Review of Urban 3D Modelling Methods for Digital Twin Creation
Authors: Ying Yue , Koeva Mila , Kuffer Monika , Zevenbergen Jaap
Published: December 2022

Increasing urbanisation has inevitably led to the continuous construction of buildings. Urban expansion and densification processes reshape cities and, in particular, the third dimension (3D), thus calling for a technical shift from 2D to 3D for property valuation. However, most property valuation studies employ 2D geoinformation in hedonic price models, while the benefits of 3D modelling potentially brought for property valuation and the general context of digital twin (DT) creation are not sufficiently explored. Therefore, this review aims to identify appropriate urban 3D modelling method(s) for city DT, which can be used for 3D property valuation (3DPV) in the future (both short-term and long-term). We focused on 3D modelling studies investigating buildings and urban elements directly linked with residential properties. In total, 180 peer-reviewed journal papers were selected between 2016 and 2020 with a narrative review approach. Analytical criteria for 3D modelling methods were explicitly defined and covered four aspects: metadata, technical characteristics, users’ requirements, and ethical considerations. From this, we derived short-term and long-term prospects for 3DPV. The results provide references for integrating 3D modelling and DT in property valuation and call for interdisciplinary collaboration including researchers and stakeholders in the real estate sector, such as real estate companies, house buyers and local governments.
Hijacking Chemical Reactions of P450 Enzymes for Altered Chemical Reactions and Asymmetric Synthesis
Authors: Rajakumara Eerappa , Saniya Dubey , Bajaj Priyanka , Rajeshwari Rajanna , Giri Jyotsnendu , Davari Mehdi D.
Published: December 2022

Cytochrome P450s are heme-containing enzymes capable of the oxidative transformation of a wide range of organic substrates. A protein scaffold that coordinates the heme iron, and the catalytic pocket residues, together, determine the reaction selectivity and regio- and stereo-selectivity of the P450 enzymes. Different substrates also affect the properties of P450s by binding to its catalytic pocket. Modulating the redox potential of the heme by substituting iron-coordinating residues changes the chemical reaction, the type of cofactor requirement, and the stereoselectivity of P450s. Around hundreds of P450s are experimentally characterized, therefore, a mechanistic understanding of the factors affecting their catalysis is increasingly vital in the age of synthetic biology and biotechnology. Engineering P450s can enable them to catalyze a variety of chemical reactions viz. oxygenation, peroxygenation, cyclopropanation, epoxidation, nitration, etc., to synthesize high-value chiral organic molecules with exceptionally high stereo- and regioselectivity and catalytic efficiency. This review will focus on recent studies of the mechanistic understandings of the modulation of heme redox potential in the engineered P450 variants, and the effect of small decoy molecules, dual function small molecules, and substrate mimetics on the type of chemical reaction and the catalytic cycle of the P450 enzymes.
Sulfatide Deficiency, an Early Alzheimer’s Lipidomic Signature, Causes Brain Ventricular Enlargement in the Absence of Classical Neuropathological Hallmarks
Authors: Palavicini Juan Pablo , Ding Lin , Pan Meixia , Qiu Shulan , Wang Hu , Shen Qiang , Dupree Jeffrey L. , Han Xianlin
Published: December 2022

Alzheimer’s disease (AD) is a neurodegenerative disease characterized by progressive memory loss and a decline in activities of daily life. Ventricular enlargement has been associated with worse performance on global cognitive tests and AD. Our previous studies demonstrated that brain sulfatides, myelin-enriched lipids, are dramatically reduced in subjects at the earliest clinically recognizable AD stages via an apolipoprotein E (APOE)-dependent and isoform-specific process. Herein, we provided pre-clinical evidence that sulfatide deficiency is causally associated with brain ventricular enlargement. Specifically, taking advantage of genetic mouse models of global and adult-onset sulfatide deficiency, we demonstrated that sulfatide losses cause ventricular enlargement without significantly affecting hippocampal or whole brain volumes using histological and magnetic resonance imaging approaches. Mild decreases in sulfatide content and mild increases in ventricular areas were also observed in human APOE4 compared to APOE2 knock-in mice. Finally, we provided Western blot and immunofluorescence evidence that aquaporin-4, the most prevalent aquaporin channel in the central nervous system (CNS) that provides fast water transportation and regulates cerebrospinal fluid in the ventricles, is significantly increased under sulfatide-deficient conditions, while other major brain aquaporins (e.g., aquaporin-1) are not altered. In short, we unraveled a novel and causal association between sulfatide deficiency and ventricular enlargement. Finally, we propose putative mechanisms by which sulfatide deficiency may induce ventricular enlargement.
Low Sulfur Amino Acid, High Polyunsaturated Fatty Acid Diet Inhibits Breast Cancer Growth
Authors: Turchi Riccardo , Tortolici Flavia , Benvenuto Monica , Punziano Carolina , De Luca Anastasia , Rufini Stefano , Faraonio Raffaella , Bei Roberto , Lettieri-Barbato Daniele , Aquilano Katia
Published: December 2022

Cancer cells may acquire resistance to stress signals and reprogram metabolism to meet the energetic demands to support their high proliferation rate and avoid death. Hence, targeting nutrient dependencies of cancer cells has been suggested as a promising anti-cancer strategy. We explored the possibility of killing breast cancer (BC) cells by modifying nutrient availability. We used in vitro models of BC (MCF7 and MDA-MB-231) that were maintained with a low amount of sulfur amino acids (SAAs) and a high amount of oxidizable polyunsatured fatty acids (PUFAs). Treatment with anti-apoptotic, anti-ferroptotic and antioxidant drugs were used to determine the modality of cell death. We reproduced these conditions in vivo by feeding BC-bearing mice with a diet poor in proteins and SAAs and rich in PUFAs (LSAA/HPUFA). Western blot analysis, qPCR and histological analyses were used to assess the anti-cancer effects and the molecular pathways involved. We found that BC cells underwent oxidative damage to DNA and proteins and both apoptosis and ferroptosis were induced. Along with caspases-mediated PARP1 cleavage, we found a lowering of the GSH-GPX4 system and an increase of lipid peroxides. A LSAA/HPUFA diet reduced tumor mass and its vascularization and immune cell infiltration, and induced apoptosis and ferroptotic hallmarks. Furthermore, mitochondrial mass was found to be increased, and the buffering of mitochondrial reactive oxygen species limited GPX4 reduction and DNA damage. Our results suggest that administration of custom diets, targeting the dependency of cancer cells on certain nutrients, can represent a promising complementary option for anti-cancer therapy.
Deep Feature Pyramid Hashing for Efficient Image Retrieval
Authors: Redaoui Adil , Belloulata Kamel
Published: December 2022

Thanks to the success of deep learning, deep hashing has recently evolved as a leading method for large-scale image retrieval. Most existing hashing methods use the last layer to extract semantic information from the input image. However, these methods have deficiencies because semantic features extracted from the last layer lack local information, which might impact the global system’s performance. To this end, a Deep Feature Pyramid Hashing DFPH is proposed in this study, which can fully utilize images’ multi-level visual and semantic information. Our architecture applies a new feature pyramid network designed for deep hashing to the VGG-19 model, so the model becomes able to learn the hash codes from various feature scales and then fuse them to create final binary hash codes. The experimental results performed on two widely used image retrieval datasets demonstrate the superiority of our method.
Hydrogen Evolution Reaction, Electrochemical CO2 Reduction, and Oxidative Photodegradation of Organic Dyes Catalyzed by Co(II) Trimethoxy-Meso-Arylporphyrin
Authors: Guergueb Mouhieddinne , Kechiche Azhar , Loiseau Frédérique , Molton Florian , Nasri Habib , Hohnsen Johannes , Klein Axel
Published: December 2022

In search of robust catalysts for redox transformations such as the hydrogen evolution reaction (HER) or CO2 to CO reduction, we stepped on the previously reported meso-tetrakis(3,4,5-trimethoxyphenyl)porphyrinato cobalt(II) complex [Co(TTMPP)]. We prepared [Co(TTMPP)] in good yields and characterized it by IR, UV-vis absorption, photoluminescence spectroscopy, and cyclic voltammetry (CV). The [Co(TTMPP)] was used as a homogeneous catalyst for the electrochemical formation of H2 (HER) in DMF (N,N’-dimethylformamide)/TFA (trifluoroacetic acid) and DMF/EtN3BF4 solutions, with high faradic efficiencies (FE). Additionally, the reduction of CO2 to CO in DMF under a CO2 atmosphere was catalyzed in DMF/TFE (TFE = 2,2,2-trifluoroethanol) and DMF/PhOH with high FE and only traces of H2 as a by-product. Turnover frequencies of 15.80 or 9.33 s−1, respectively were determined from CV experiments or controlled potential electrolysis in the presence of 1eq. TFE. They were lower with PhOH as proton source with 13.85 or 8.31 s−1, respectively. Further, [Co(TTMPP)] as a solid catalyst (suspension) allowed the photodecomposition of the organic dyes methylene blue (MB) and rhodamine B (RhB) using H2O2 under visible light irradiation. The photocatalyst was photostable over five cycles. A photocatalytic mechanism was proposed based on trapping experiments of reactive oxygen species.
Impact of Initial Population Density of the Dubas Bug, Ommatissus lybicus (Hemiptera: Tropiduchidae), on Oviposition Behaviour, Chlorophyll, Biomass and Nutritional Response of Date Palm (Phoenix dactylifera)
Authors: Al-Abri Nasser , Al-Raqami Suad , Al-Hashemi Maryam , Al-Shidi Rashid , Al-Khatri Salim , Ray Rumiana V.
Published: December 2022

The Dubas bug (Ommatissus lybicus) is an economically significant pest of date palms. In this study, the effect of the population density of O. lybicus on chlorophyll, measured by the soil plant analysis development (SPAD) chlorophyll meter, palm biomass, and the nutritional composition of date palms, were investigated. A further objective was to determine significant relationships between the population density of O. lybicus, the number of honeydew droplets, and oviposited eggs. Reductions of up to 8–11% and 29–34% in chlorophyll content and plant biomass, respectively, were caused by infestations exceeding 300 nymphs per palm seedling. Increasing the population density of O. lybicus to 600 insects per palm decreased oviposition by females, suggesting intraspecific competition for resources. There was a significant relationship between honeydew droplets produced by the pest population and chlorophyll content in the rachis, suggesting that treatment can be triggered at 3–6 nymphs/leaflet. Egg oviposition was preferentially on the rachis. Ca, Mg, K, and P were the main nutrients affected by the activity of the pest. Mg content was associated with reduced chlorophyll content under increasing pest density, suggesting that supplemental nutrition can be potentially utilized to sustain chlorophyll and increase palm tolerance to pest infestation.
Circulating Regulatory B-Lymphocytes in Patients with Acute Myocardial Infarction: A Pilot Study
Authors: Volodarsky Igor , Shimoni Sara , Haberman Dan , Mirkin Vita , Fabrikant Yakov , Yoskovich Mashriki Tal , Zalik Adi , George Jacob
Published: December 2022

Background: Inflammation plays on important role in plaque instability and acute coronary syndromes. The anti-inflammatory effects of B-regulatory lymphocytes (B-regs) in atherosclerosis was tested mainly in animal models with inconclusive results. Herein, we studied for the first time, levels of circulating B-regs in patients with acute myocardial infarction (MI). Methods: We examined circulating levels of B-regs by flow cytometry in 29 patients with recent ST-segment elevation MI and 18 patients with stable angina pectoris (SAP) and coronary artery disease. We re-assessed B-reg levels on average 4 months later. Results: The mean level of CD20+ cells was similar in patients with MI and patients with SAP (p = 0.60). The levels of CD24hiCD38hi cells among CD20+ cells were 5.7 ± 4% and 11.6 ± 6% in patients with MI and SAP, respectively, (p < 0.001). The level of CD24hiCD38hi B-regs remained related to acute MI after correcting for age, gender, and risk factors. Circulating levels of CD24hiCD38hi B-regs in patients with MI did not change significantly at follow-up in a small patient groups (p = 0.408). Conclusions: Circulating B-regs are reduced in patients with MI compared to patients with SAP. This finding may shed further light on the inflammatory pathophysiologic factors related to plaque rupture.
Augmentation Index in Patients with Thoracic Aortic Aneurysm: A Matched Case-Control Study
Authors: Baumgartner Patrick , Rejmer Protazy , Osswald Martin , Malesevic Stefan , Sievi Noriane A. , Roeder Maurice , Herth Jonas , Stämpfli Simon F. , Clarenbach Christian F. , Tanner Felix C. , Gaisl Thomas , Kohler Malcolm
Published: December 2022

Thoracic aortic aneurysms (TAA) may be associated with complications such as rupture and dissection, which can lead to a fatal outcome. Increased central arterial stiffness has been proposed to be present in patients with TAA compared to unmatched controls. We aimed to assess whether wall properties in patients with TAA are also altered when compared to a matched control group. Applanation tonometry was performed in 74 adults with TAA and 74 sex, age, weight, height, and left ventricular ejection fraction matched controls. Subsequently analysis of the pulse wave was done using the SphygmoCor System. For comparing the two groups, AIx was adjusted to a heart rate of 75/min (AIx@75). 148 1-to-1 matched participants were included in the final model. There was no significant difference in the Alx@75 between the TAA group and the matched control group [mean (SD) of 24.7 (11.2) % and 22.8 (11.2) %, p = 0.240]. Adjusted for known cardiovascular risk factors, there was no association between TAA and AIx@75. Patients with TAA showed comparable arterial wall properties to cardiovascular risk factor matched controls. Since higher arterial stiffness is associated with TAA progression, it remains to be investigated if increased central arterial stiffness is a relevant factor of TAA emergence.
To Keep or Not to Keep? The Hamletic Umbilical Dilemma: Preservation versus Reconstruction of the Umbilicus in Vertical Abdominoplasty
Authors: Nisi Giuseppe , Giudice Martino , Bacchini Stefano , Fasano Giorgio , Verre Luigi , Cuomo Roberto , Grimaldi Luca
Published: December 2022

(1) Background: The role of the umbilical scar and its repositioning remains one of the most important surgical steps in the execution of any type of abdominoplasty, including those involving “inverted-t” or “fleur de lys” incisions. A consequence of this is a surgeon’s Hamletic dilemma: to keep or not to keep the original umbilical scar? (2) Methods: A retrospective observational study was conducted on all patients undergoing “T-inverted” abdominoplasty at the Department of Plastic Surgery of the Santa Maria alle Scotte University Hospital, Siena, between January 2018 and December 2020. Twelve months after the surgery we submitted to all patients the U-score questionnaire about their feelings about their umbilicus’s appearance. Patients could assign a score from 1 (very dissatisfied) to 4 (very satisfied) to each of the five items of the score. (3) Results: The average of the scores attributed by the nine patients in whom the navel was preserved is 13 (Range 10–17), while in patients on whom a navel reconstruction was performed, the mean score is 16.8 (Range 12–20). The mean score of patients with a reconstructed umbilicus is, therefore, statistically higher than that of the other group of patients (t-value = 3.88, p = 0.000374) with an average increase of 3.8 points. (4) Conclusions: We can state that the reconstruction of a new navel is the right answer to the Hamletic dilemma in patients having undergone vertical or anchor abdominoplasty.
Impact of Sodium Zirconium Cyclosilicate Therapy on Nutrition Status in Patients with Hyperkalemia
Authors: Imamura Teruhiko , Fujioka Hayato , Narang Nikhil , Kinugawa Koichiro
Published: December 2022

Background: Restriction of oral potassium intake is a necessary dietary intervention for managing chronic hyperkalemia. These dietary changes may have negative impacts on nutrition status, particularly in geriatric cohorts with multiple comorbidities. Sodium zirconium cyclosilicate (SZC) is a newly introduced potassium binder intended for patients with hyperkalemia. We aimed to investigate whether the improvements in hyperkalemia with SZC therapy and the liberation of potassium intake restriction may improve nutrition status in a primarily geriatric patient cohort with chronic hyperkalemia. Methods: Patients who were maintained on SZC therapy for at least 3 months were retrospectively studied. Following the initiation of SZC and improvement in hyperkalemia, instructions on the restriction of potassium intake were loosened according to the institutional protocol. The change in nutrition status during the 3 month therapeutic period using SZC was investigated by referencing the prognostic nutritional index score (PNI), geriatric nutritional risk index score (GNRI), and controlling nutritional status (CONUT) scores. Results: A total of 24 patients (median age 78 years, 58% men, median estimated glomerular filtration rate 29.8 mL/min//1.73 m2) were included. Serum potassium level decreased significantly from 5.4 (5.1, 5.9) to 4.4 (4.2, 4.9) mEq/L without any drug-related adverse events, including hypokalemia. Nutrition-related scores, including the PNI score, the GNRI score, and the CONUT score, improved significantly following 3 months of SZC therapy (p < 0.05 for all). Psoas muscle volume and average days for one movement also improved significantly during the therapeutic period (p < 0.05 for both). Conclusions: Mid-term SZC therapy and liberation of potassium intake restriction might improve nutrition status in geriatric patients with chronic hyperkalemia.
Global Incidence and Prevalence of Gaucher Disease: A Targeted Literature Review
Authors: Castillon Genaro , Chang Shun-Chiao , Moride Yola
Published: December 2022

Incidence and prevalence estimates for Gaucher disease (GD) are scarce for this rare disease and can be variable within the same region. This review provides a qualitative synthesis of global GD incidence and prevalence estimates, GD1–3 type-specific and overall, published in the last 10 years. A targeted literature search was conducted across multiple databases from January 2011 to September 2020, including web-based sources and congress proceedings to May 2021. Searches yielded 490 publications, with 31 analyzed: 20 cohort studies (15 prospective, 5 retrospective), 6 cross-sectional studies, 5 online reports (most from Europe (n = 11) or North America (n = 11); one multiregional). Across all GD types, incidence estimates ranged 0.45–25.0/100,000 live births (16 studies), lowest for Asia-Pacific. Incidence of GD1: 0.45–22.9/100,000 live births (Europe and North America) and GD3: 1.36/100,000 live births (Asia-Pacific only). GD type-specific prevalence estimates per 100,000 population were GD1: 0.26–0.63; GD2 and GD3: 0.02–0.08 (Europe only); estimates for GD type unspecified or overall ranged 0.11–139.0/100,000 inhabitants (17 studies), highest for North America. Generalizability was assessed as “adequate”or “intermediate” for all regions with data. GD incidence and prevalence estimates for the last 10 years varied considerably between regions and were poorly documented outside Europe and North America. Data for GD2 and GD3 were limited.
Cardiac Autonomic Function in Long COVID-19 Using Heart Rate Variability: An Observational Cross-Sectional Study
Authors: Menezes Junior Antonio da Silva , Schröder Aline Andressa , Botelho Silvia Marçal , Resende Aline Lazara
Published: December 2022

Background: Heart rate variability is a non-invasive, measurable, and established autonomic nervous system test. Long-term COVID-19 sequelae are unclear; however, acute symptoms have been studied. Objectives: To determine autonomic cardiac differences between long COVID-19 patients and healthy controls and evaluate associations among symptoms, comorbidities, and laboratory findings. Methods: This single-center study included long COVID-19 patients and healthy controls. The heart rate variability (HRV), a quantitative marker of autonomic activity, was monitored for 24 h using an ambulatory electrocardiogram system. HRV indices were compared between case and control groups. Symptom frequency and inflammatory markers were evaluated. A significant statistical level of 5% (p-value 0.05) was adopted. Results: A total of 47 long COVID-19 patients were compared to 42 healthy controls. Patients averaged 43.8 (SD14.8) years old, and 60.3% were female. In total, 52.5% of patients had moderate illness. Post-exercise dyspnea was most common (71.6%), and 53.2% lacked comorbidities. CNP, D-dimer, and CRP levels were elevated (p-values of 0.0098, 0.0023, and 0.0015, respectively). The control group had greater SDNN24 and SDANNI (OR = 0.98 (0.97 to 0.99; p = 0.01)). Increased low-frequency (LF) indices in COVID-19 patients (OR = 1.002 (1.0001 to 1.004; p = 0.030)) and high-frequency (HF) indices in the control group (OR = 0.987 (0.98 to 0.995; p = 0.001)) were also associated. Conclusions: Patients with long COVID-19 had lower HF values than healthy individuals. These variations are associated with increased parasympathetic activity, which may be related to long COVID-19 symptoms and inflammatory laboratory findings.
The Usefulness of MRI Dynamic Flow Sequences in Differentiating High- and Low-Flow Vascular Malformations
Authors: Majewska Natalia Krystyna , Stański Marcin , Ryczkowska Joanna , Wątorek Jacek , Stańska Alicja , Wykrętowicz Mateusz , Pyda Małgorzata , Katulska Katarzyna
Published: December 2022

Peripheral arteriovenous malformations (PVMs) can be classified into high-flow malformations (HFVMs) and low-flow malformations (LFVMs). Adequate distinguishment is crucial for therapeutic decision and can be done using dynamic contrast-enhanced MRI (DCE-MRI). The main aim of this retrospective study was to determine the diagnostic value of quantitative DCE-MRI ratios for differentiation between HFVM and LFVM, their optimal cut-off points, and predictive values. DCE-MRI time-resolved angiography with stochastic trajectory (TWIST) examinations of 90 patients with PVMs were included [28 HFVM (31%), 62 LFVM (69%)]. The measurements of artery-lesion time, maximum lesion enhancement, slope of the enhancement curve, and maximum percentage increase of signal intensity (SI) were obtained. The optimal cut-offs for HFVMs calculated using the Youden index were: for slope of enhancement curve < 8.7 s (sensitivity of 86%, specificity of 89%), artery-lesion time ≤ 5.6 s (sensitivity of 89%, specificity of 77%), time to maximum enhancement ≤ 30 s (sensitivity of 94%, specificity of 100%), and maximum percentage enhancement of the lesion > 662% (sensitivity of 68%, specificity of 69%). To summarize, DCE-MRI is very valuable for differentiation between HFVM and LFVM, especially if quantitative measurements are done.
Genome-Wide Pleiotropy Study Identifies Association of PDGFB with Age-Related Macular Degeneration and COVID-19 Infection Outcomes
Authors: Chung Jaeyoon , Vig Viha , Sun Xinyu , Han Xudong , O’Connor George T. , Chen Xuejing , DeAngelis Margaret M. , Farrer Lindsay A. , Subramanian Manju L.
Published: December 2022

Age-related macular degeneration (AMD) has been implicated as a risk factor for severe consequences from COVID-19. We evaluated the genetic architecture shared between AMD and COVID-19 (critical illness, hospitalization, and infections) using analyses of genetic correlations and pleiotropy (i.e., cross-phenotype meta-analysis) of AMD (n = 33,976) and COVID-19 (n ≥ 1,388,342) and subsequent analyses including expression quantitative trait locus (eQTL), differential gene expression, and Mendelian randomization (MR). We observed a significant genetic correlation between AMD and COVID-19 infection (rG = 0.10, p = 0.02) and identified novel genome-wide significant associations near PDGFB (best SNP: rs130651; p = 2.4 × 10−8) in the pleiotropy analysis of the two diseases. The disease-risk allele of rs130651 was significantly associated with increased gene expression levels of PDGFB in multiple tissues (best eQTL p = 1.8 × 10−11 in whole blood) and immune cells (best eQTL p = 7.1 × 10−20 in T-cells). PDGFB expression was observed to be higher in AMD cases than AMD controls {fold change (FC) = 1.02; p = 0.067}, as well as in the peak COVID-19 symptom stage (11–20 days after the symptom onset) compared to early/progressive stage (0–10 days) among COVID-19 patients over age 40 (FC = 2.17; p = 0.03) and age 50 (FC = 2.15; p = 0.04). Our MR analysis found that the liability of AMD risk derived from complement system dysfunction {OR (95% CI); hospitalization = 1.02 (1.01–1.03), infection = 1.02 (1.01–1.03) and increased levels of serum cytokine PDGF-BB {β (95% CI); critical illness = 0.07 (0.02–0.11)} are significantly associated with COVID-19 outcomes. Our study demonstrated that the liability of AMD is associated with an increased risk of COVID-19, and PDGFB may be responsible for the severe COVID-19 outcomes among AMD patients.
Gender, Stress, and Well-Being in Adulthood
Authors: Pérez J. Iván , Matud M. Pilar
Published: December 2022

Exposure to stressors may be one of the most critical components of health and well-being. Although research on stress and health abounds, most studies have focused on establishing that stress is harmful to physical and mental health whereas less attention has been paid to analysing the effects of stress on well-being. The main purpose of this study is to investigate the relevance of gender in the association of stress with well-being in adulthood. A cross-sectional study was conducted with 1578 women and 1507 men from the Spanish general population aged between 30 and 59. All participants were assessed by eight self-reports measuring chronic stress, life events, daily hassles, eudaimonic well-being, life satisfaction, masculine/instrumental and feminine/expressive traits, coping styles, and social support. Although stress does not affect women’s eudaimonic well-being, a greater number of life events and more daily hassles rendered lower life satisfaction in women. Men’s greater chronic stress was associated with lower eudaimonic well-being and life satisfaction; moreover, a greater number of life events was associated with men’s lower life satisfaction. We conclude that gender is relevant in the stress and well-being of adults as well as in the association between stress and well-being.
Decomposing Organic Molecules on Titanium with Vacuum Ultraviolet Light for Effective and Rapid Photofunctionalization
Authors: Suzumura Toshikatsu , Matsuura Takanori , Komatsu Keiji , Ogawa Takahiro
Published: December 2022

Ultraviolet (UV) photofunctionalization counteracts the biological aging of titanium to increase the bioactivity and osseointegration of titanium implants. However, UV photofunctionalization currently requires long treatment times of between 12 min and 48 h, precluding routine clinical use. Here, we tested the ability of a novel, xenon excimer lamp emitting 172 nm vacuum UV (VUV) to decompose organic molecules coated on titanium as a surrogate of photofunctionalization. Methylene blue as a model organic molecule was coated on grade 4 commercially pure titanium and treated with four UV light sources: (i) ultraviolet C (UVC), (ii) high-energy UVC (HUVC), (iii) proprietary UV (PUV), and (iv) VUV. After one minute of treatment, VUV decomposed 57% of methylene blue compared with 2%, 36%, and 42% for UVC, HUVC, and PUV, respectively. UV dose-dependency testing revealed maximal methylene blue decomposition with VUV within one minute. Equivalent decomposition was observed on grade 5 titanium alloy specimens, and placing titanium specimens in quartz ampoules did not compromise efficacy. Methylene blue was decomposed even on polymethyl methacrylate acrylic specimens at 20–25% lower efficiency than on titanium specimens, indicating a relatively small contribution of titanium dioxide-mediated photocatalytic decomposition to the total decomposition. Load-testing revealed that VUV maintained high efficacy of methylene blue decomposition regardless of the coating density, whereas other UV light sources showed low efficacy with thin coatings and plateauing efficacy with thicker coatings. This study provides foundational data on rapid and efficient VUV-mediated organic decomposition on titanium. In synergy with quartz ampoules used as containers, VUV has the potential to overcome current technical challenges hampering the clinical application of UV photofunctionalization.
Acute Hormonal Responses to Multi-Joint Resistance Exercises with Blood Flow Restriction
Authors: Vilaça-Alves José , Magalhães Patrício S. , Rosa Claudio V. , Reis Victor M. , Garrido Nuno D. , Payan-Carreira Rita , Neto Gabriel R. , Costa Pablo B.
Published: December 2022

The purpose of this study was to investigate the acute effects of multi-joint resistance exercises (MJRE) with blood flow restriction on hormonal responses. Ten men participated in the study and underwent two experimental protocols in random order: four sets (30, 15, 15, and 15 reps, respectively) of MJRE (half squat and horizontal chest press) were performed with 20% of 1RM and a rest time between sets of 30 s, combined with intermittent blood flow restriction (LI + BFR protocol); and four sets (8, 8, 8, 20 reps, respectively) of the same MJRE performed with 75% of 1RM load (HI protocol), with a 90 s rest between the first three sets and 30 s between the third to the fourth set. Blood samples were collected before (PRE), immediately after (POST), and 15 min after the performance of MJRE (POST15). A time effect was observed for growth hormone (GH) and insulin-like-growth-factor-1-binding-protein-3 (IGFPB-3), but no protocol effects or interactions between protocol and times were observed (p > 0.05). There was no effect of either protocol or time (p > 0.05) on total testosterone, free testosterone, or cortisol concentrations. However, significant (p < 0.05) increases were observed in the GH serum concentrations of 2072.73% and 2278.5%, HI, and LI + BFR protocols, respectively, from the PRE to POST15 test. In addition, there was an increase of 15.30% and 13.29% in the IGFPB-3 concentrations (p < 0.05) from PRE to POST0 times for HI and LI + BFR protocols, respectively. Furthermore, there was a decrease of −6.17% and −11.54%, p = 0.00, between the times POST0 to POST15 in the IGFPB-3 for the HI and LI + BFR protocols, respectively. It is concluded that multi-joint resistance exercises combined with intermittent blood flow restriction seemed to promote acute hormonal responses in a manner similar to traditional exercise with high loads. Future studies may investigate whether chronic use of LI + BFR with MJRE may promote muscle hypertrophy.
High Frequency of Self-Diagnosis and Self-Treatment in a Nationally Representative Survey about Superficial Fungal Infections in Adults—United States, 2022
Authors: Benedict Kaitlin , Gold Jeremy A. W. , Wu Karen , Lipner Shari R.
Published: December 2022

Data about the prevalence, diagnosis, treatment, and public knowledge of superficial fungal infections in the United States are scarce. These infections are a growing concern given the emergence of antifungal drug resistance. We analyzed data from a national survey of nearly 6000 U.S. adults. Overall, 114 (2.7%) participants reported having ringworm and 415 (10.0%) reported a fungal nail infection in the past 12 months; 61.4% of participants with any superficial fungal infection were self-diagnosed. Most patients (55.5%) used over-the-counter antifungals. The common nature of superficial fungal infections and the high rates of self-diagnosis and treatment indicate that community education about these infections should be considered a public health priority.
Coaxial-Robotic Single-Site Myomectomy: Surgical Outcomes Compared with Robotic Single-Site Myomectomy by Propensity Score Matching Analysis
Authors: Choi Su Hyeon , Won Seyeon , Lee Nara , Shim So Hyun , Kim Mi Kyoung , Kim Mi-La , Jung Yong Wook , Yun Bo Seong , Seong Seok Ju
Published: December 2022

Background: The aim of this study was to introduce a coaxial-robotic single-site myomectomy (C-RSSM) technique to compensate for the shortcomings of robotic single-site myomectomy (RSSM) using semi-rigid instruments and to compare the surgical outcomes of C-RSSM and RSSM. Methods: The medical records of 13 consecutive women who had undergone C-RSSM and 131 consecutive women who had undergone RSSM were retrospectively reviewed. Patient characteristics and surgical outcomes after propensity score matching were evaluated and compared between the two groups. Results: According to the propensity score matching results, the C-RSSM group had a lower estimated blood loss (75.0 vs. 210.5 mL, p = 0.001) and a shorter operating time (101.0 vs. 146.1 min, p = 0.008) relative to the RSSM group. In RSSM, there was one case of conversion to conventional laparoscopy and four cases of conversion to the multi-site robotic approach. There was no case of conversion from C-RSSM to conventional laparoscopy or the multi-site robotic approach. Conclusions: C-RSSM was found to be associated with shorter operative time and lower estimated blood loss. However, further prospective studies are needed to confirm these advantages.
Monte Carlo-Based Radiobiological Investigation of the Most Optimal Ion Beam Forming SOBP for Particle Therapy
Authors: Kantemiris Ioannis , Pappas Eleftherios P. , Lymperopoulou Georgia , Thanasas Dimitrios , Karaiskos Pantelis
Published: December 2022

Proton (p) and carbon (C) ion beams are in clinical use for cancer treatment, although other particles such as He, Be, and B ions have more recently gained attention. Identification of the most optimal ion beam for radiotherapy is a challenging task involving, among others, radiobiological characterization of a beam, which is depth-, energy-, and cell type- dependent. This study uses the FLUKA and MCDS Monte Carlo codes in order to estimate the relative biological effectiveness (RBE) for several ions of potential clinical interest such as p, 4He, 7Li, 10Be, 10B, and 12C forming a spread-out Bragg peak (SOBP). More specifically, an energy spectrum of the projectiles corresponding to a 5-cm SOBP at a depth of 8 cm was used. All secondary particles produced by the projectiles were considered and RBE was determined based on radiation-induced Double Strand Breaks (DSBs), as calculated by MCDS. In an attempt to identify the most optimal ion beam, using the latter data, biological optimization was performed and the obtained depth–dose distributions were inter-compared. The results showed that 12C ions are more effective inside the SOBP region, which comes at the expense of higher dose values at the tail (i.e., after the SOBP). In contrast, p beams exhibit a higher DSOPB/DEntrance ratio, if physical doses are considered. By performing a biological optimization in order to obtain a homogeneous biological dose (i.e., dose × RBE) in the SOBP, the corresponding advantages of p and 12C ions are moderated. 7Li ions conveniently combine a considerably lower dose tail and a DSOPB/DEntrance ratio similar to 12C. This work contributes towards identification of the most optimal ion beam for cancer therapy. The overall results of this work suggest that 7Li ions are of potential interest, although more studies are needed to demonstrate the relevant advantages. Future work will focus on studying more complex beam configurations.
Responses at Individual Gamma Frequencies Are Related to the Processing Speed but Not the Inhibitory Control
Authors: Griškova-Bulanova Inga , Živanović Marko , Voicikas Aleksandras , Pipinis Evaldas , Jurkuvėnas Vytautas , Bjekić Jovana
Published: December 2022

The link between the state of networks underlying the generation of periodic responses at gamma ranges and cognitive outcomes is still poorly understood. In this study, we tested the idea that the individual differences in the ability to generate responses to auditory stimulation at gamma frequencies may underlie the individual differences in the inhibitory control. We focused on the processing speed and accuracy in the Bivalent Shape Task (a cognitive inhibition task assessing attentional interference) and explored the relationship with responses at 40 Hz and at individual gamma frequencies (IGFs, assessed utilizing auditory envelope-following responses in 30–60 Hz range). In a sample of 70 subjects, we show that individual measures (phase-locking index and event-related spectral perturbation) of the ability to generate gamma-range activity are not related to the individual differences in inhibitory control but rather reflect basic information processing speed in healthy young subjects. With the individualized approach (at IGFs), the observed associations were found to be somewhat stronger. These findings have important implications for the interpretation of gamma activity in neuropsychiatric disorders.
Australasian Genetic Counselors’ Perceptions of Their Role in Supporting Clients’ Behavior Change
Authors: Jacobs Chris , Turbitt Erin , McEwen Alison , Atkins Lou
Published: December 2022

Genetic testing does not always change health behavior. Effective behavior change requires a theory-driven coordinated set of activities (behavior change techniques). Genetic counselors are ideally positioned to facilitate behavior change. We aimed to explore genetic counselors’ perceptions of their role in supporting clients’ behavior change to inform the design of an intervention. Recruitment was via a professional organization and genetics services. Data were collected from 26 genetic counselors via qualitative focus groups/interview. Transcripts were analyzed using thematic analysis and mapped to the COM-B model. We identified three behaviors genetic counselors wanted clients to change: attend appointments, access information, and share information with family members. Strategies for changing clients’ behavior included: assessing needs and capabilities, providing information and support, enabling and monitoring behavior change. Barriers included lack of behavior change skills and knowledge, lack of time, and beliefs about ownership of healthcare, directiveness of behavior change, and scope of practice. Equipping genetic counselors to deliver behavior change requires (i) education in behavior change theory and behavior change techniques, (ii) integration of capability, opportunity and motivation assessment into existing practice, and (iii) development of evidence-based strategies using behavior change tools to focus discussions and promote clients’ agency to change their behavior.
Comparison of Multifactor Asset Pricing Models in the South African Stock Market [2000–2016]
Authors: Mukoyi Lenia , Ogujiuba Kanayo K.
Published: December 2022

The quest for parsimonious models has been a key objective in asset pricing. However, there appears to be no consensus on the most successful asset pricing strategy in the literature, especially for the South African Market. Using financial statements from January 2000 to December 2015, this article explores how market anomalies affect the performance of securities in the Johannesburg Stock Exchange’s (JSE’s) resources, industrial, and finance sectors. We investigated the efficacy of several asset pricing models and their capacity to account for market anomalies in the JSE’s resources, industrial, and financial sectors, as well as the applicability of the Fama and French five-factor model. The study used multiple regression techniques and applied stationarity and cointegration methods to ensure robust results. Results also suggest that when the FF5FM is implemented, there is statistical significance at the 10% level for the CMA in the resources sector as the value factor disappears. The FF5FM results in the industrial sector show a significance level of 5% in the SMB. The financial sector seems to have the majority of the style-based risk factors as the SMB is positively significant at a 5% level, the HML is significant at a 1% level, and the CMA is negatively significant at a 10% level of significance. The results suggest that the Carhart Four Factor model is the best to use in all market conditions. Results also show that value becomes redundant in a bullish market, but the opposite holds in a bearish market for a model with operating profitably and investing factors. These findings highlight the necessity for investors to determine which investment risk elements produce abnormal returns in both bearish and bullish market circumstances before investing.
Consumers’ Behavioural Intentions to Reuse Recommender Systems: Assessing the Effects of Trust Propensity, Trusting Beliefs and Perceived Usefulness
Authors: Acharya Nirmal , Sassenberg Anne-Marie , Soar Jeffrey
Published: December 2022

Recommender systems (RSs) are widely utilised across industries as tools to provide users with recommendations based on their preferences. This paper reports on an examination of the influence of trusting beliefs on behavioural intentions to reuse RSs, emphasising the effects of trust propensity, perceived usefulness and product type. A distinctive contribution of this study is the research model, which integrated perceived usefulness as an antecedent of trusting beliefs. Data collected in Australia with 366 participants were used. A new approach (MICOM and PLS-MGA) was performed to assess the moderating effect of product type. The research results indicate that trust propensity has a positive and significant direct effect on consumers’ trusting beliefs in an ongoing relationship. The results also suggest that consumers’ trusting beliefs and perceived usefulness of RSs positively and significantly affect their intention to reuse RSs. Perceived usefulness of RSs is more important compared to trusting beliefs in predicting consumers’ behavioural intention to reuse RSs. Trusting beliefs partially mediate the impact of perceived usefulness on behavioural intentions to reuse RSs. The results also showed an insignificant difference between the effect of different product types on Australian consumers’ behavioural intention to reuse RSs. These results have implications for the design of RSs.
Analysis of the Reciprocal Feedback between Glacier Tourism Development and Regional Economic Growth in Hailuogou
Authors: Wang Yanxia , Yang Jianping , Tang Fan , Ge Qiuling , He Qingshan , Dai Xun
Published: December 2022

Ice and snow tourism has yielded considerable socioeconomic benefits, especially for the countries and regions that are rich in ice and snow resources. Boosted by the Beijing Winter Olympics, China’s ice and snow tourism economy is likely to usher in a period of high-quality development. This study utilized Hailuogou Glacier Forest Park, a relatively well-developed glacier tourism area in China, as the study area. We used data on the regional GDP of Ganzi Prefecture and the comprehensive tourism revenue of Hailuogou scenic area from the period of 1990–2021 to quantitatively analyze the reciprocal feedback relationships between the regional economic growth of Ganzi Prefecture and the development of Hailuogou glacier tourism. The analyses were performed through the construction of a VAR model and through conducting robustness tests using the instrumental variable method. The results show that there is a long-term equilibrium cointegration relationship between regional economic growth in Ganzi Prefecture and tourism development in the Hailuogou scenic area, with each 1% increase in the former driving a corresponding growth of 2.01% in the latter. There is an asymmetric reciprocal feedback relationship between the economic growth of Ganzi Prefecture and the development of tourism in the Hailuogou scenic area. Economic growth in Ganzi Prefecture significantly contributes to the development of glacier tourism in Hailuogou over a longer period of time, with a contribution rate of 49%; meanwhile, the development of tourism in the Hailuogou scenic area has a limited effect on the quality and acceleration of economic development in Ganzi Prefecture, with a contribution rate of 16%. Based on the above results, relevant policy recommendations are proposed to provide a theoretical basis and decision-making reference for the high-quality development of the Hailuogou scenic area in the post-COVID-19 and post-Winter Olympics era.
Physical Urban Area Identification Based on Geographical Data and Quantitative Attribution of Identification Threshold: A Case Study in Chongqing Municipality, Southwestern China
Authors: Wang Dan , Kong Liang , Chen Zhongsheng , Yang Xia , Luo Mingliang
Published: December 2022

Although some methods have identified the physical urban area to a certain extent, the driving factors for the identification threshold have not been studied deeply. In this paper, vector building data and road intersection data are used for comparative validation based on the urban expansion curve method to identify the physical urban area using the meso-city scale. The geographical detector technique is used to detect how and to what extent the urban spatial structure factors, geographical environment factors and social economic factors affect the optimal distance threshold of 22 administrative districts in the Chongqing municipality. The results based on the vector buildings are more precise and show the characteristics of the physical urban area of core-periphery distribution and the distribution along the water corridor. From the results of quantitative attribution, it was found that the road network density, building density, urbanization rate and urban population density, and their interaction with regional GDP, play a critical role in the optimal distance threshold, with the index value of influence degree ≥0.79. Under the influence of different factors, the optimal distance thresholds of 22 administrative districts show adaptive characteristics. Looking forward to the future, this study provides ideas for further research on the morphological characteristics and distribution laws of multi-spatial scale cities.