bluuebunny/crossref_metadata_2025 huggingface dataset:
Prophylactic Efficacy of Allium sativum Essential Oil on Hepatic Tissues of Mice Model Exposed to Inorganic Lead Salt
Authors: Sharma Kusum , Sharma Veena
Published: December 2023

Hypothesis: Lead is a pervasive environmental pollutant that is major threat for human health. Allium sativum essential oil could impart possible protection from Lead Nitrate (LN) as it contains organosulfur compounds which possess various pharmacological potential including antioxidant, anti-inflammatory, anticancer, anti-apoptotic and other activities as well. Parameters Studied: The ameliorative role of Allium sativum essential oil on hepatic tissue damage caused by Lead nitrate was evaluated through oxidative stress, biochemical parameters, oxidative Stress Index (OSI) and hepatic biomarkers. Methodology and Results: In this study, six groups of animals were taken. These groups were: control animals, toxicant treated animals (LN), LN + plant oil low and high dose treated animals, LN + silymarin treated animals and LN + vehicle oil control group. Lead nitrate exposure significantly decreased the antioxidant molecules mainly SOD, CAT, Gpx, GSH, GST, TPC and increased the lipid peroxidation content, Oxidative Stress Index (OSI), liver indices, Total Cholesterol Content (TCC) and biochemical parameters [ALT, AST, ALP] In addition to this, Lead nitrate increased the level of hepatic biomarkers such as cytp4502E1, 5’-nucleotidase, and γ-glutamyltranspeptidase and decreased the cytb5 content in hepatic tissues. Conclusion: Antioxidant activity of Allium sativum Essential Oil (ASEO) prevented oxidative stress and restored the level of liver indices, biochemical parameters, and hepatic biomarkers in Lead nitrate-intoxicated mice. Therefore, ASEO can be considered as a promising protective strategy against Lead nitrate-induced hepatotoxicity.
Comunicación UPB: Un legado de medio siglo de inspiración intelectual
Authors: Marín Ochoa Beatriz Elena
Published: December 2023

La revista Comunicación, publicación de la Facultad de Comunicación Social – Periodismo de la Escuela de Ciencias Sociales de la Universidad Pontificia Bolivariana circuló por primera en 1974, en una joven comunidad académica que buscaba posicionar su saber y dar cuenta de las discusiones y avances investigativos gestados en sus aulas. Durante estos cincuenta años, la revista se ha distinguido por un ejercicio de producción científica, riguroso y comprometido, con la sociedad y en el que han participado varias generaciones de alumnos, docentes, egresados e investigadores. La publicación, que inicio como una revista impresa con un enfoque de divulgación científica, hoy hace parte de la hemeroteca digital de la UPB y avanza en su camino a la indexación, que incluye sistemas como: Redib, Clase, Dialnet, Doaj, Circ, Communication Source (EBSCO), Erihplus y Latindex; y bases de información y resumen como: Aura, Miar, Road, Base, Periódicos Capes (Brasil), LatinRev, PkPIndex, E Revistas, Europub, Hesburgh Libraries y Academia.edu. Pero, además, Comunicación es una revista de acceso abierto gratuito para los lectores y autores, y un referente de publicación científica universitaria que desea continuar siendo un espacio ideal para la discusión, la reflexión, la innovación y la apropiación social de nuevo conocimiento entre sus lectores de las comunidades académicas locales, nacionales e internacionales.
Procesión y protesta: La resignificación del dolor de las familias en el Caso Ayotzinapa
Authors: Díaz Delgado Abraham Zaíd
Published: December 2023

El Caso Ayotzinapa refiere a la muerte y desaparición forzada de un grupo de estudiantes normalistas de Guerrero (México), entre los días 26 y 27 de septiembre del 2014. A lo largo de más de nueve años, el tema ha sido recurrente en los medios de comunicación nacional e internacionalmente. No obstante, las noticias suelen encuadrar las acciones multitudinarias que se llevan a cabo en la Ciudad de México, capital del país, comúnmente con un discurso descalificante y criminalizador, tanto de las protestas como de las víctimas de la desaparición forzada. De los años 2019 a 2021, tuve la oportunidad de realizar un trabajo etnográfico con algunas familias de los estudiantes desaparecidos y con sus compañeros de la Escuela Normal Rural “Raúl Isidro Burgos” de Ayotzinapa. Esta fotoserie expone la manifestación del proceso colectivo de conversión del dolor y del sufrimiento en organización y movilización social de la familia Mondragón Fontes y los actuales estudiantes de Ayotzinapa, a partir del caso de Julio César Mondragón Fontes (JCMF), quién fue ejecutado y torturado hasta el punto de desollarle el rostro, motivo por el cuál su familia y compañeros siguen exigiendo justicia y castigo a quienes resulten responsables.
Jogos e educação matemática: uma revisão sistemática sobre o uso de jogos nos anos iniciais do ensino fundamental
Authors: Oliveira Iandria Souza , Dutra Débora Santos de Andrade , Aquije Glória Maria de Farias Viégas
Published: December 2023

Este trabalho apresenta uma revisão sistemática da literatura, utilizando uma abordagem qualitativa, realizada a partir da busca de artigos no Portal de Periódicos da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). A pesquisa teve como objetivo analisar o uso de jogos como recurso pedagógico para o ensino de matemática nos anos iniciais. Foram analisados 26 artigos que atenderam aos critérios de inclusão e exclusão estabelecidos. Os resultados apontaram para a predominância de jogos manuais em grupo, destacando a socialização como núcleo do jogo pedagógico. Com relação à construção dos jogos, os dados mostraram que a maioria foi adaptada dos jogos existentes. Os conteúdos mais utilizados com os jogos foram: sistema de numeração decimal (SND), operações, geometria, probabilidade e estatística. Além disso, a maioria das práticas foi desenvolvida nas 3ª e 4ª séries do ensino fundamental. Quanto à participação das crianças no processo, verificou-se que a grande maioria participou plenamente da aplicação e construção dos jogos. Observou-se, também, que a maioria deu algum destaque à avaliação no processo (antes e/ou depois da aplicação dos jogos). A análise desses resultados evidencia a importância dos jogos como recurso pedagógico para o ensino de matemática, principalmente em relação ao engajamento das crianças no processo de aprendizagem.
Games and mathematics education: a systematic review on the use of games in the initial years of elementary school
Abstract
This paper presents a systematic literature review, using a qualitative approach, conducted from the search for articles in Portal de Periódicos da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). The research aimed to analyze the use of games as a pedagogical resource for teaching mathematics in the early years. Twenty-six articles that met the established inclusion and exclusion criteria were analyzed. The results pointed to the predominance of group manual games, highlighting socialization as the core of the pedagogical game. Regarding the games construction, the data showed that most of them were adapted from existing games. The most common contents used with the games were decimal numbering system (SND), operations, geometry, probability, and statistics. Furthermore most of the practices were developed in the 3rd and 4th grades of elementary school. As for the participation of children in the process, it was found that the vast majority participated fully in the application and construction of the games. It was also observed that the majority gave some emphasis to the evaluation in the process (before and/or after the application of the games). The analysis of these results show the importance of games as a pedagogical resource for teaching mathematics, especially in relation to the engagement of children in the learning process.
Hormon Combinations for Root Induction of Pear
Authors: M Gitta Kocsisné
Published: December 2023

Propagation and root-induction of in vitro plants are regulated by different types and concentrations of phytohormones. The main objective of our study was to observe the effects of different hormone combinations on rooting habit of micropropagated in vitro pear plants. Different amounts of cytokinin (BAP) (0.0; 0,01; 0.02; 0.03 mg l-1) and auxin (2,4 D) (1;2;3 mgl-1) were applied in 8 different combinations of two treatments. Differences among hormone combinations were recorded by rooting habit, number of roots and root length.
Potential of Agroforestry for Climate Change Mitigation through Carbon Sequestration: Review Paper
Authors: Tefera Yirefu
Published: December 2023

Climate change is widely accepted that human activities are now increasingly influencing changes in global climate. Carbon emission is higher from deforestation and forest degradation. However, this can be managed through the sustainable management of land and forest. Thus, the purpose of this review paper is to present the compiled studies which have been done on the potential of agroforestry in climate change mitigation through carbon sequestration. The enhancement of forest C stocks through agroforestry can be considered as one of the main options for reducing greenhouse gases in the atmosphere Agroforestry is a unique extensive action involving the integration of woody plants with crop and livestock components. Therefore, in the recent decades, the role of agroforestry in climate change mitigation received strong attention. Thus, the greatest role of agroforestry in relation to climate change is in mitigating the emissions of CO2 by sequestering carbon from the atmosphere. Because the adoption of agroforestry practice has greater potential to increase C sequestration of predominantly agriculture dominated landscapes than the monocrop agriculture.
Knowledge Management for Agricultural Development
Authors: Cartaxo de Castro Ahiram Brunni
Published: December 2023

People’s technological, political and cultural and consumption habit changes have a strong impact on economic sectors, as the methodology for using data, information and knowledge changes, with emphasis to the modern agricultural sector. This delimited the objective of this research, which focused on raising antecedents that favor the nations’ knowledge management and agricultural development. Concerning the research methodology, this study uses a descriptive approach and was developed through a meta-analysis of results of studies selected from the Scopus database on “knowledge management” and “agricultural development”, from 2008 to 2018. As for the main results found, among the ten antecedents of knowledge management identified for the promotion of agricultural development, half of them related with data science. Thus, the investment in data science can be seen as substantial for the agricultural development in nations. This way, as a conclusive summary, there is the promotion and adoption of several applications for science data, as well as the generation of national environments of innovation, which are the most relevant aspects of knowledge management for the agricultural development in nations.
Physiological Potencial of Seeds of Physalis Peruviana L. Depending on Different Managements
Authors: Veronica Veronica
Published: December 2023

In the process of agricultural production of Cape Gooseberry, the obtaining of new plants occurs commercially by the sexual route, being the seed the main form. The physiological potential of seeds may be influenced by some cultural tracts. This study aimed to evaluate the physiological potential of Physalis peruviana L. Seeds cultivated in different stoning, pruning and harvest time systems. The experiment was carried out in Londrina PR, using a completely randomized design, in a 5x4x2 factorial scheme, with four replications, containing five harvest times of the fruits (117, 124, 130, 137 and 141 days after transplanting), Four Tutoring systems (“UEL tutoring”, “adaptive” V “tutoring”, no tutoring and “vertical tutoring”) and two types of pruning (with and without Desbrota). For the physiological potential of the seeds, first count germination, germination, germination speed index, seedling length and dry mass were performed. Data were subjected to analysis of normality and homogeneity and compared by Tukey’s tests for qualitative variables, and by linear regression tests for quantitative variables, at a 5% probability level. It was found that the desbrotte, stoning and harvesting of fruits made at 117 days after transplanting positively influenced the physiological potential of seeds of physalis peruviana L. The adapted inverted V-tutoring presented Higher value for seedling dry matter.
PEG-Induced Drought Stress During Germination: Effects on Soybean Germplasm
Authors: Pavli Ourania I
Published: December 2023

Soybean is the one of the most important oilseed and protein sources worldwide. Among environmental stresses negatively affecting soybean, drought is considered as the most limiting factor in terms of yield losses encountered. In view of the need for improving drought tolerance, this study aimed at determining the seed germination and seedling growth potential under drought conditions as an approach to identify tolerant genotypes at early growth stages. The genetic material consisted of a set of commercial and pre-commercial varieties (Adonai, Neoplanta, Celina, Zora, PR92M22, P21T45, PR92M35, PR92B63, PR91M10). Drought stress was induced by different concentrations of polyethylene glycol (0, 5, 10 and 20 % PEG-6000). Genotype performance was assessed on the basis of Germination Percentage (GP), seed Water Uptake (WU), seedling Water Content (WC), root and shoot length and number of seedlings with abnormal phenotype. Stress substantially affected all traits associated to germination and seedling growth, with its effects though differing significantly among genotypes. Overall findings point to the superiority of varieties Neoplanta, Adonai, PR92M22 and Celina. Further, it was evidenced that GP as well as root and shoot length form suitable criteria for drought tolerance, while WU and WC did not allow the classification of genotypes in terms of drought tolerance. Our findings provide conclusive evidence that traits associated to germination and growth potential may be employed for revealing genetic variability related to drought tolerance, thus enabling their exploitation as screening criteria for drought tolerance. Upon confirmation of its validity, such short-cut selection approach may considerably upgrade the efficiency of breeding procedures targeted at the improvement of drought tolerance in soybean.
Influence of Different Calcium Compounds and Fruit Development Stages on Yield, Fruit Quality and Shelf Life of ‘Granny Smith’ Apples
Authors: Fallahi Esmaeil 
Published: December 2023

Calcium (Ca) plays major roles on the storage life and quality apples. In this study, the influence of calcium chloride (CaCl2) and two organic calcium compounds including Calcicat and Folical at four different times of application on the quality and shelf life of ‘Granny Smith’ apples during two growing seasons. Quantitative and qualitative attributes were evaluated at harvest and after three- and six-months cold storage. In the first year, Folical all-season and mid-season sprays resulted in a significant increase in Ca concentration. In the second year, early-season spray resulted in significant Ca increase compared to control. In the first year, the early-season spray program of Folical had the highest yield and fruit weight. The use of calcium compounds in all timing programs reduced fruits soluble solids concentration (SSC) at harvest compared to control treatments. In both years, at harvest, no significant difference was observed among treatments regarding the ‘Granny smith’ apple firmness. In the first year, the chlorophyll content of ‘Granny Smith’ apple peels were affected by spray timing and the type of calcium compound. In both years, Fruits treated with Ca had lower ethylene concentration and brightness index (L*) than controls. In the second year, Folical spray decreased the percentage of superficial scald incidence for three months storage. During the first year, all-season Calcicat spray and in the second year early-season Folical spray showed the lowest percentage of scald disorder after six months storage. In the first year, the all-season spray program and in the second year Folical spray decreased the severity of scald after three months of storage.
Targeting in Protracted Crises: Niger Case Study
Authors: Merttens Fred , Hodey Louis , Doyle Alexandra
Published: December 2023

Targeting social assistance in situations of protracted conflict, displacement or recurrent climate shocks so that it reaches those most in need in a timely and effective manner, and without doing further harm, is a complex technical and political challenge for development and humanitarian actors across government and non-government sectors. Trade-offs involving costs beyond the economic – such as risk of exclusion, and concerns over protection and social cohesion – raise key questions about who to target, how to target or whether to target at all (i.e. through universal coverage or lotteries). While targeting effectiveness is fairly well researched in stable development contexts, there is much less understanding and evidence about what works best in protracted crisis settings. This paper is one of three country case studies covering Ethiopia, Niger, and Nigeria. Each case study focuses on a specific time period to demonstrate how the challenge of targeting might be approached in situations of protracted crises based on actual historical examples. The objective of this approach is to generate insights on the topic of targeting in a comparative way and by considering vulnerability as a dynamic condition. The case studies will be used to produce a synthesis paper that will bring findings together to draw out general lessons for targeting social assistance in crisis contexts. This case study focuses on the 2012 Sahel drought, which produced a food security emergency in Niger. Using two years of panel data (2011 and 2014) from either side of the 2012 drought crisis in the Sahel, we analyse who was affected by the shock and how they were impacted. We use the data to model the notional performance of different potential targeting approaches – had they been used at the time – to indicate the types of choices and trade-offs that may be necessary when selecting appropriate targeting criteria for responses to similar crises in the future. Finally, we also consider the status of enabling conditions (such as mobile phone network and electricity coverage) for implementing different targeting approaches in shock-responsive social assistance.
Pemenuhan Kesejahteraan Psikososial terhadap Narapidana Lanjut Usia
Authors: Ramadhan Rizqan Syahru , Subroto Mitro
Published: December 2023

Penelitian ini bertujuan untuk mendeskripsikan pemenuhan kesejahteraan psikososial terhadap narapidana lanjut usia. Metode penelitian yang digunakan kualitatif dengan pendekatan kepustakaan. Hasil penelitian menjelaskan bahwa semua warga negara memiliki kedudukan dan hak yang sama di mata hukum. Pemberian sanksi atas pelanggaran hukum di Indonesia memegang teguh prinsip ‘Equality before the law’ yaitu semua orang mendapatkan perlakuan yang sama di mata hukum tidak terkecuali bagi seseorang yang telah lanjut usia. Namun demikian, bagi lansia perlu ada perlakuan khusus, terutama pada aspek psiko-sosial. Masalah psikososial yang tidak diatasi dengan baik akan menimbulkan gangguan keseimbangan (homeostasis) sehingga membawa lansia ke arah kerusakan atau kemerosotan (deterioritasi). Perlakuan khusus terhadap lansia, bukanlah merupakan bentuk diskriminasi bagi warga binaan lain yang berusia muda. Hal ini semata merupakan bentuk pemenuhan kebutuhan warga binaan lanjut usia agar mereka tetap dapat meningkatkan taraf kesejahteraan sosialnya serta memelihara kemampuan fisik, mental dan sosialnya selama berada di dalam Lapas.
Pengaruh Pelatihan Kerja dan Kompensasi Terhadap Kinerja Frontliner Bank Sumsel Babel A. Rivai
Authors: Revaldi Muhamad , Syarif M. Amirudin
Published: December 2023

Penelitian ini bertujuan untuk mengetahui pengaruh pelatihan kerja dan kompensasi terhadap kinerja frontliner Bank Sumsel Babel Arivai. Jenis penelitian ini adalah kuantitatif. Populasi dalam penelitian ini adalah 38 frontliner. Pengambilan data menggunakan jenis sampel jenuh yaitu semua populasi dijadikan sampel. Teknik analisis yang digunakan adalah Structural Equation Model (SEM) dengan menggunakan SmartPLS 3.0. Hasil penelitian ini menunjukkan bahwa secara parsial pelatihan kerja dan kompensasi memiliki pengaruh signifikan terhadap kinerja. Nilai R-Square adalah sebesar 0,790 yang artinya variabel pelatihan kerja dan kompensasi mempengaruhi kinerja sebesar 79%, sedangkan 21% lainnya dipengaruhi oleh variabel lain diluar penelitian ini.
Molecular analysis of the bacterial microbiome in the rumen of Algerian dromedary
Authors: Sahraoui Naima , Boukert Razika , Fertoul Ayoub , Taminiau Bernard , Hornick Jean-Luc
Published: December 2023

The bacterial community of the forestomach plays important roles in the digestive processes of ruminants and pseudo-ruminants. To investigate the rumen microbiota in the pseudo-rumen of camels (Camelus dromedarius) raised in a natural environment in Algeria, bacterial diversity was determined from 25 dromedaries using 16S rRNA gene amplicon sequencing. A total of 25 bacterial phyla were identified across all the samples, including Firmicutes (close to 85℅), Bacteroidetes (about 12%) and to a lesser extent Proteobacteria (< 1%), with these three phyla together accounting for more than 97% of all sequences. Our results are consistent with previous observations of bacterial communities diversity and abundancy in the rumen or pseudo-rumen of other ruminant species (either domestic or wild), although the abundance of individual bacterial phyla showed remarkably high disparities. Links between the richness and type of diet and the composition of the rumen microbiome are discussed.
KETIDAKPASTIAN LINGKUNGAN DAN MANAJEMEN LABA DENGAN KEMAMPUAN MANAJERIAL SEBAGAI VARIABEL MODERASI
Authors: Iswajuni  , Bryan Luke
Published: December 2023

Penelitian ini bertujuan untuk menguji moderasi kemampuan manajerial pada hubungan ketidakpastian lingkungan terhadap manajemen laba. Sampel penelitian adalah perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia periode 2017-2021 sebanyak 344 sampel. . Hasil penelitian menunjukkan bahwa ketidakpastian lingkungan berhubungan positif terhadap manajemen laba. Hasil penelitian mengindikasikan bahwa ketidakpastian lingkungan berhubungan positif terhadap manajemen laba dan moderasi kemampuan manajerial terbukti memperlemah hubungan ketidakpastian lingkungan terhadap manajemen laba.
MACHINE LEARNING FOR E-COMMERCE FRAUD DETECTION
Authors: Damayanti Rahayu , Adrianto Zaldy
Published: December 2023

The study examines the effectiveness, challenges, and best machine learning algorithms for detecting e-commerce fraud. This study uses a systematic literature review to evaluate the effectiveness of machine learning-based e-commerce fraud detection, identify challenges, and identify the most effective techniques. The study examinedliterature extracted from the ScienceDirect, Emeralds, Wiley, and Springer databases, identifying 29 publications from recognized journals from 2012–2022, filtered using limitations and quality assessment criteria, and assessing paper eligibility. This study reveals that machine learning significantly enhances the accuracy of detecting e-commerce fraud. Yet, there are a number of issues that need to be resolved before machine learning can be utilized to detect e-commerce fraud. Poorer-quality data distribution is the biggest challenge in detecting e-commerce fraud. In order to determine the best machine learning strategy, the model's accuracy was also evaluated, and it was discovered that random forests performed the best in terms of accuracy. This study increases theoretical contributions as a continuation of previous research relevant to the concept of machine learning in detecting fraud in e-commerce. Then, based on the random forest's greater precision, it provides practical advice to e-commerce firms as a basis for decision-makers to find a suitable machine learning technique for fraud detection.
FINANCIAL FRAUD DETECTION AND MACHINE LEARNING ALGORITHM (UNSUPERVISED LEARNING): SYSTEMATIC LITERATURE REVIEW
Authors: Husnaningtyas Nadia , Totok Dewayanto
Published: December 2023

This research aims to assess the usage of unsupervised learning in detecting financial fraud across various financial industries by identifying cognitive constructs, benefits, economic optimization, and challenges associated with fraud detection necessitating innovative approaches for effective detection. This study conducts Systematic Literature Review following PRISMA protocol for article selection of 27 journal articles published between 2010 and 2023, sourced from Scopus database. The analysis discloses that unsupervised learning has been implemented across diverse financial sectors, including online payments, insurance, and prominently in banking, especially for identifying anomalies in credit card transactions. K-Means is the most popular method used in unsupervised learning. Nevertheless, there are ongoing challenges that require solutions to ensure the efficacy of machine learning implementation, encompassing issues like class imbalance and the complexity of fraudulent activities. In theoretical terms, this research provides an understanding of cognitive concepts, benefits and applications, challenges, and practical recommendations in the use of unsupervised learning for financial fraud detection. This is useful for practical implementation, benefiting industry practitioners in selecting appropriate models with datasets that have the potential to enhance detection system accuracy and reduce financial losses due to fraud.
DOENÇA GORDUROSA HEPÁTICA NÃO ALCOÓLICA E COLELITÍASE: ASSOCIAÇÃO COMUM EM PACIENTES COM SÍNDROME METABÓLICA
Authors: Martins Lígia Vieira Uchoa , Lima José Milton de Castro , Hyppólito Elodie Bomfim
Published: December 2023

Objetivos: Verificar a relação de causa e efeito entre a Doença Gordurosa Hepática Não Alcoólica (DGHNA) e Colelitíase. Metodologia: Trata-se de uma pesquisa bibliográfica para a qual foram conduzidas buscas por artigos nas bases de dados MEDLINE, LILACS e SciELO. Foram incluídos estudos originais realizados em adultos (idade ≥ 18 anos), publicados nos idiomas inglês, português e espanhol, entre os anos de 2005 e 2020. Resultados: Os achados da literatura demostram que há uma forte relação entre DGHNA e Colelitíase, com evidências de que tanto a DGHNA configura-se em fator de risco independente para Colelitíase, quanto o inverso. Embora não seja consenso, a maioria dos estudos conclui que a associação entre DGHNA e Colelitíase ocorre principalmente no sexo feminino. Os estudos trazem informações de que, em pacientes submetidos a colecistectomia e biópsia hepática no mesmo tempo cirúrgico, houve associação entre o aumento da prevalência de Colelitíase e a piora do grau de atividade necro-inflamatória e fibrose hepáticas. Conclusões: A DGHNA e Colelitíase parecem afetar principalmente o sexo feminino, compartilhando fatores de risco semelhantes e podendo ter uma relação de causa e efeito recíproca.
Regulators of clonal hematopoiesis and physiological consequences of this condition
Authors: Park Eunbee , Evans Megan A. , Walsh Kenneth
Published: December 2023

Clonal hematopoiesis (CH) is a prevalent condition that results from somatic mutations in hematopoietic stem cells. When these mutations occur in “driver” genes, they can potentially confer fitness advantages to the affected cells, leading to a clonal expansion. While most clonal expansions of mutant cells are generally considered to be asymptomatic since they do not impact overall blood cell numbers, CH carriers face long-term risks of all-cause mortality and age-associated diseases, including cardiovascular disease and hematological malignancies. While considerable research has focused on understanding the association between CH and these diseases, less attention has been given to exploring the regulatory factors that contribute to the expansion of the driver gene clone. This review focuses on the association between environmental stressors and inherited genetic risk factors in the context of CH development. A better understanding of how these stressors impact CH development will facilitate mechanistic studies and potentially lead to new therapeutic avenues to treat individuals with this condition.
Pemberdayaan Petani Gula Aren Melalui Standarisasi Produk dan Pembentukan Kelompok Usaha Bersama untuk pengembangan Ekonomi Kreatif Desa Balikterus, Pulau Bawean
Authors: Gabriel Azmi Alvian , Sarumaha Vinsensia Shinta Purnama Dewi , Indramawarni Sazkia , Utami Deva Pramesti Budi , Prihastiti Adinda Siska , Annafi'ah Rohmatun Nazilah , Kamaliyah Nurul , Ferdiawati Mira , Widyantoro Catur , Karsono Syahrul Huda , Yudana Christian Dewa , Romadlon Laksamana Muhammad Haris Noer
Published: December 2023

Desa Balikterus menjadi salah satu pusat produksi gula aren terbesar yang ada di Pulau Bawean. Selama ini potensi gula aren yang terdapat pada desa Balikterus masih belum dioptimalkan oleh masyarakat sekitar karena kurangnya pengetahuan akan bahan baku dan juga minimnya akses informasi terkait penjualan hingga standarisasi produk yang diinginkan oleh pasar. Pengabdian masyarakat ini bertujuan untuk meningkatkan keteram­pilan pengembangan kualitas gula aren serta menguatkan manajemen organisasi melalui pembentukan Kelompok Usaha Bersama pengrajin gula aren di Desa Balikterus.  Kegiatan ini ditujukan untuk Ibu-ibu pengrajin gula aren tradisional di Desa Balikterus sebanyak 25 orang. Metode pelaksanaan pengabdian yang digunakan adalah edukasi, sosialisasi, pelatihan, serta pendampingan kepada masyarakat setempat. Kegiatan ini dilaksanakan mulai dari bulan Agustus hingga November 2022. Dengan dilaksanakannya kegiatan pengabdian masyarakat ini dapat disimpulkan bahwa terbentuknya kelompok usaha bersama di Desa Balikterus khususnya dusun balikbak hilir dapat meningkatkan kapasitas produksi dan pemasaran, terbentuknya merk dagang dari gula aren yang berbadan hukum (Sorren), dihasilkannya buku panduan standarisasi proses produksi gula aren, serta dihasilkan bentuk gula dan kemasan yang easy to use.Balikterus Village is one of the largest palm sugar production centers on Bawean Island. It was found that the potential for palm sugar in Balikterus village has not been optimized by the surrounding community due to lack of knowledge of raw materials and a lack of access to information related to sales to standardization of products desired by the market. This community service aims to improve skills in developing the quality of palm sugar and strengthen organizational management through the establishment of a Joint Business Group for palm sugar craftsmanship in Balikterus Village. This activity was designed for 25 Balikterus Village traditional palm sugar craftsmen. Community service was carried out through education, outreach, training, and assistance to the local community. This activity was carried out from August to November 2022. It can be concluded that the formation of a joint business group in Balikterus Village, particularly in the Balikbak Hilir hamlet, can increase production and marketing capacity, form a legal entity trademark for palm sugar (Sorren), produce a manual for the standardization of the palm sugar production process, and produce an easy-to-use form of sugar and packaging.
Pelatihan Payroll Management Menggunakan Visual Basic for Application (VBA) pada Badan Usaha Milik Desa (BUMDESA) Tirta Mandiri, Ponggok
Authors: Kusumawardhani Arinta , Dirgatama Chairul Huda Atma , Ibad Irsyadul
Published: December 2023

Payroll Management dengan bantuan teknologi sangat penting diterapkan di Badan Usaha Milik Desa, tujuannya adalah agar kinerja pegawai lebih efektif dan efisien. Metode pengabdian yang digunakan yaitu (1) Analisa Kebutuhan, (2) Sosialisasi, (3) Focus Group Discussion (FGD), (4) Pelatihan, dan (5) Monitoring. Tujuan dan hasil akhir dari kegiatan program kemitraan masyarakat ini yaitu: 1) Peningkatan kapasitas SDM BUMDesa Tirta Mandiri dalam penguasaan keterampilan untuk melaksanakan dan mengimplementasikan payroll management guna terciptanya efektivitas dan efisiensi kerja; 2) Peningkatan pengetahuan SDM mengenai Visual Basic for Application (VBA). Hasil peningkatan diukur dengan melakukan pre-test dan post-test kepada peserta pelatihan. Selanjutnya akan dilakukan pelatihan dan pendampingan lebih lanjut mengenai payroll management pada pegawai manajerial dan unit usaha BUMDEs Tirta Mandiri berjumlah 20 orang yang dilakukan pada bulan MeiOktober 2022 menggunakan Visual Basic for Application (VBA) pada BUMDesa Tirta Mandiri secara optimal.Payroll Management with the help of technology is very important to implement in Village Owned Enterprises, the goal is to make employee performance more effective and efficient. The service method used is (1) Needs Analysis, (2) Outreach, (3) Focus Group Discussion (FGD), (4) Training, and (5) Monitoring. The objectives and final results of the activities of this community partnership program are: 1) Increasing the capacity of BUMDesa Tirta Mandiri human resources in mastering skills to carry out and implement payroll management in order to create work effectiveness and efficiency; 2) Increasing HR knowledge regarding Visual Basic for Application (VBA). The improvement results were measured by conducting pre-tests and post-tests on the training participants. Furthermore, further training and assistance will be carried out regarding payroll management for managerial employees and business units of Tirta Mandiri BUMDEs, totaling 20 people, which will be carried out in May - October 2022 using Visual Basic for Application (VBA) at BUMDesa Tirta Mandiri optimally.
Pelatihan Pengelolaan Sampah Organik dan Anorganik di Pesantren Putri Darul Huda Mayak Ponorogo
Authors: Soraya Siti Zazak , Zubaidah Alfiani
Published: December 2023

Sampah merupakan masalah yang sangat erat kaitannya dengan kehidupan manusia. Pengelolaan sampah yang baik dapat berdampak pada kesehatan manusia dan menciptakan lingkungan yang bersih dan nyaman untuk belajar. Tujuan kegiatan pengabdian masyarakat ini untuk menumbuhkan kesadaran santri agar membuang sampah pada tempatnya, menciptakan lingkungan belajar yang bersih dan nyaman, serta melatih membuat karya dari sampah anorganik. Kegiatan ini diikuti oleh tujuh santri putri Pesantren Darul Huda Mayak Tonatan Ponorogo yang berasal dari perwakilan kelas pada Juli–Agustus 2021. Metode yang digunakan adalah pendekatan asset-based community development (ABCD) dengan mengembangkan potensi yang dimiliki. Hasil dari evaluasi kegiatan ini menunjukkan bahwa pelatihan pengelolaan sampah organik dan anorganik dapat meningkatkan wawasan dan keterampilan santri dalam memilah sampah organik dan anorganik serta membuat kerajinan tangan dari sampah anorganik. Dengan demikian, kegiatan pengabdian yang dilaksanakan cukup berhasil menjadikan para santri semakin sadar terhadap kebersihan lingkungan serta kreatif dalam memanfaatkan barang bekas menjadi karya seni.Garbage is a problem that is closely related to human life. Good waste management can impact human health and create a clean and comfortable environment for learning. This community service project aims to raise students' awareness of proper trash disposal, create a clean and comfortable learning environment, and train them to create works out of inorganic waste. Seven female students from the Darul Huda Mayak Tonatan Ponorogo Islamic Boarding School came from class representatives to participate in this activity in July-August 2021. The method used is an asset-based community development (ABCD) approach by developing the ready-owned potential. The evaluation of this activity revealed that training in organic and inorganic waste management could improve students' understanding and skills in sorting organic and inorganic garbage and manufacturing handicrafts from inorganic waste. Thus, the service activities made the students more aware of environmental cleanliness and creatively utilized used goods in artworks.
PERBEDAAN AKTIVITAS SGOT DAN SGPT PADA DERAJAT CEDERA FRAKTUR TERBUKA PASIEN DI RSUD ULIN BANJARMASIN
Authors: Andika Noventri , Putera Husna Dharma , Hendriyono F.X
Published: December 2023

Fraktur terbuka merupakan fraktur dengan kontak jaringan dan lingkungan luar melalui kulit sehingga terjadi kontaminasi bakteri yang dapat menimbulkan infeksi. Fraktur terbuka diklasifikasi berdasarkan derajat trauma jaringan di sekitarnya menggunakan klasifikasi Gustillo-Anderson. Semakin tinggi derajat trauma, memungkinkan terjadinya gangguan keseimbangan homeostasis yang memicu penurunan fungsional organ (MODS) terkhususnya hati, terlihat melalui SGOT dan SGPT. Tujuan penelitian ini adalah mengetahui apakah terdapat perbedaan aktivitas SGOT dan SGPT pada derajat fraktur terbuka pasien di RSUD Ulin Banjarmasin periode Januari 2019 - Juni 2022. Penelitian bersifat retrospektif analitik dengan metode cross-sectional. Dengan teknik total sampling, didapatkan 38 sampel yang sesuai kriteria inklusi. Analisis data menggunakan uji Kruskall-Wallis. Hasil penelitian didapatkan aktivitas SGOT pada tipe I sebanyak 26 U/L, tipe II dengan rerata 26±3,03 U/L, dan tipe III dengan median 36 U/L, nilai terendah 13 U/L nilai tertinggi 182 U/L. Aktivitas SGPT didapatkan pada tipe I sebanyak 28 U/L, tipe II dengan median 15,5 U/L, nilai terendah 13 U/L nilai tertinggi 36 U/L, dan tipe III dengan median 23 U/L, nilai terendah 10 U/L, nilai tertinggi 150 U/L. Tidak terdapat perbedaan bermakna (p = 0,129) aktivitas SGOT dan SGPT pada derajat cedera fraktur terbuka pasien di RSUD Ulin Banjarmasin periode januari 2019 – juni 2022.
HUBUNGAN FREKUENSI DAN JUMLAH PENGGUNAAN COTTON BUD PADA TOILET TELINGA TERHADAP KELUHAN TELINGA BERDENGING BERDASARKAN NILAI
Authors: Bukit Alfyonika Oktaviani Br , Qamariah Nur , Muthmainah Noor , Rofi’i Achmad , Kaidah Siti
Published: December 2023

Menjaga kebersihan telinga sangat penting dilakukan. Cotton bud adalah alat yang paling sering digunakan. Penggunaan cotton bud dapat menyebabkan trauma di liang telinga sehingga mudah menimbulkan tanda radang yang menyebabkan keluhan telinga berdenging. Tujuan penelitian ini adalah mengetahui hubungan frekuensi dan jumlah penggunaan cotton bud pada toilet telinga terhadap keluhan telinga berdenging berdasarkan nilai VAS. Penelitian dilakukan dengan observasional analitik menggunakan pendekatan cross-sectional. Hasilnya didapatkan frekuensi penggunaan cotton bud yang paling banyak adalah sering sebanyak 69,2%. Jumlah penggunaan cotton bud yang paling banyak adalah jumlah sedikit sebanyak 76,9%. Intensitas keluhan telinga berdenging yang paling banyak adalah ringan. Analisis data dilakukan dengan uji Chi Square Fisher Exact Test. Kesimpulannya adalah tidak terdapat hubungan yang bermakna, baik pada variabel frekuensi penggunaan cotton bud dengan keluhan telinga berdenging berdasarkan nilai VAS (p value=1,00), maupun pada analisis hubungan jumlah cotton bud dengan keluhan telinga berdenging berdasarkan nilai VAS (p value=1,00).
Analytical Solution of the Rayleigh – Plesset Equation Filled with Van Der Waals Gas for Various Isoprocesses
Authors:   Moscow State University of Civil Engineering, Gasanov M. V. ,   Politecnico di Milano, Gulkanov A. G. ,   Moscow State University of Civil Engineering, Modestov K. A.
Published: December 2023

In this paper, we consider a mathematical model of the dynamics of the behavior of a spherically symmetric Rayleigh – Plesset bubble in the van der Waals gas model. The analysis of the model takes into account various isoprocesses without the presence of condensation and a model that takes into account condensation in an isothermal process. In each case, various characteristics are searched for, such as oscillation frequency (linear/small oscillations), damping factor, relaxation time, decrement, and logarithmic decrement. Solutions are found in quadratures for various parameters of the equation. The theoretical results obtained are compared with the results of the numerical solution of the Cauchy problem for various isoprocesses.
Herpesviruses mimic zygotic genome activation to promote viral replication
Authors: Full Florian , Walter Stephanie , Neugebauer Eva , Tan Jiang , Drayman Nir , Franke Vedran , Tay Savaş , Landthaler Markus , Akalin Altuna , Ensser Armin , Wyler Emanuel
Published: December 2023

DUX4 is a germline transcription factor and a master regulator of zygotic genome activation. During early embryogenesis, DUX4 is crucial for maternal to zygotic transition at the 2-8-cell stage in order to overcome silencing of genes and enable transcription from the zygotic genome. In adult somatic cells, DUX4 expression is silenced and its activation in adult muscle cells causes the genetic disorder Facioscapulohumeral Muscular Dystrophy (FSHD).
Here we show that herpesviruses from alpha-, beta- and gamma-herpesvirus subfamilies as well as papillomaviruses actively induce DUX4 expression to promote viral transcription and replication. We demonstrate that HSV-1 immediate early proteins directly induce expression of DUX4 and its target genes including endogenous retroelements, which mimics zygotic genome activation. We further show that DUX4 directly binds to the viral genome and promotes viral transcription. DUX4 is functionally required for herpesvirus infection, since genetic depletion of DUX4 by CRISPR/Cas9 abrogates viral replication.
Our results show that herpesviruses induce DUX4 expression and its downstream germline-specific genes and retroelements, thus mimicking an early embryonic-like transcriptional program that prevents epigenetic silencing of the viral genome and facilitates herpesviral gene expression.
Analysis College Students' attitude towards the use of ChatGPT in their academic activities: Effect of intent to use, verify information and responsible use
Authors: Enriquez Benicio Gonzalo Acosta , Ballesteros Marco Agustín Arbulú , Jordan Olger Huamaní , Roca Carlos López , Tirado Karina Saavedra
Published: December 2023

Background In recent years, the application of artificial intelligence (AI) in education has increased worldwide. The launch of ChatGPT - 3, posed great challenges for higher education, given its popularity among university students. The present study aimed to analyze the attitude of university students towards the use of ChatGPT in their academic activities.
Method The study was oriented to the quantitative approach and had a non-experimental design of applied type. An online survey was administered to the 499 participants.
Results The results demonstrated nine out of 12 supported hypotheses: importance (β=0.193*), ease of use (β=0.204**), risk (β=-0.104**), interest (β=0.238**), boredom (β=-0.145**), positive emotions (β=0.418***), acceptance (β=0.441***), intention to use frequently (β=0.509***), intention to verify information, and responsible use (β=0.806***). Implications of the findings from previous research are discussed, providing a unified theory of attitude towards ChatGPT-UTAC that empirically tests the underlying constructs in students' attitudes toward ChatGPT use.
Conclusion Ease of use, intention to use frequently, acceptance, and intention to verify information influenced the behavioral intention to use ChatGPT responsibly. On the one hand, the study provides suggestions for HEIs to implement improvements in their educational curricula to take advantage of the potential benefits of AI and contribute to AI literacy.
Self-supervised artificial intelligence predicts recurrence, metastasis and disease specific death from primary cutaneous squamous cell carcinoma at diagnosis
Authors: Carucci John , Coudray Nicolas , Juarez Michelle , Criscito Maressa , Quiros Adalberto , Wilken Reason , Cullison Stephanie Jackson , Stevenson Mary , Doudican Nicole , Yuan Ke , Aquino Jamie , Klufas Daniel , North Jeffrey , Yu Siegrid , Murad Fadi , Ruiz Emily , Schmults Chrysalyne , Tsirigos Aristotelis
Published: December 2023

Primary cutaneous squamous cell carcinoma (cSCC) is responsible for ~ 10,000 deaths annually in the United States. Stratification of risk of poor outcome (PO) including recurrence, metastasis and disease specific death (DSD) at initial biopsy would significantly impact clinical decision-making during the initial post operative period where intervention has been shown to be most effective.. In this multi-institutional study, we developed a state-of-the-art self-supervised deep-learning approach with interpretability power and demonstrated its ability to predict poor outcomes of cSCCs at the time of initial biopsy. By highlighting histomorphological phenotypes, our approach demonstrates that poor differentiation and deep invasion correlate with poor prognosis. Our approach is particularly efficient at defining poor outcome risk in Brigham and Women’s Hospital (BWH) T2a and American Joint Committee on Cancer (AJCC) T2 cSCCs. This bridges a significant gap in our ability to assess risk among T2a/T2 cSCCs and may be useful in defining patients at highest risk of poor outcome at the time of diagnosis. Early identification of highest-risk patients could signal implementation of more stringent surveillance, rigorous diagnostic work up and identify patients who might best respond to early postoperative adjunctive treatment.
Rare Middle Triassic coleoids from Alpine-Carpathian system: A new records from Slovakia and their significance
Authors: Kostak Martin , Schlögl Ján , Fuchs Dirk , Havrila Milan , Kolar-Jurkovšek Tea , Vörös Attila , Havelcová Martina , Šurka Juraj , Havrila Jakub , Holcová Katarína
Published: December 2023

The two stratigraphically well constrained (by ammonites and conodonts) coleoid remains have been recorded in the Triassic (Anisian) dark-grey organodetritic limestones (Ráztoky Limestone) of Western Carpathians (Hronic Nappe). The facies originated between carbonate ramp and basinal development. It yields highly diversificated cephalopod fauna including nautiloids (2 taxa), ammonoids (7 taxa) and indetermined aulacoceratids. Two unusual coleoid specimens are referred to genus Mojsisovicsteuthis (M. boeckhi) and probably to a new taxon (described as Breviconoteuthis aff. breviconus herein) possessing similar morphological features of genus Breviconoteuthis (Phragmoteuthida) and/or Zugmontites. Based on index ammonites and conodonts, both records are of the uppermost Trinodosus through the lowermost Reitzi zones (Anisian – lower Illyrian). While the genus Mojsisovicsteuthis has been widely dispersed (however its records are rare), the occurrence of Breviconoteuthis and Zugmontites is strictly limited to the Alpine-Carpathian region. Compare to the holotype and additional specimens stored in the Hungarian Natural History Museum, the overal shell of Mojsisovicsteuthis and its size has been reconstructed. Its relationship to aulacoceratids and phragmoteuthids is briefly discussed. Geochemical record provided a relevant signal of the existence of algal meadows which may represent an analogy with later sea-grasses.