bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Pemberian Pupuk UREA dan Pupuk Kotoran Sapi Terhadap Pertumbuhan Bibit Tanaman Kelapa Sawit (Elaeis guineensis Jacq)
Authors: Mahdalena  , Siti Mutmainah
Published: February 2023

ABSTRACT

 

Tujuan Penelitian untuk mengetahui pengaruh pupuk Urea dan pupuk Kotoran Sapi serta Interaksi kedua perlakuan tersebut terhadap pertumbuhan bibit kelapa sawit (E. guineensis Jacq). Penelitian dilaksanakan di lahan praktik Fakultas Pertanian Universitas Widya Gama Mahakam Samarinda Jl. KH. Wahid Hasyim I, Kelurahan Sempaja Selatan, Kecamatan Samarinda Utara, Kota Samarinda, Provinsi Kalimatan Timur Penelitian ini dilaksanakan selama 4 (empat) bulan, mulai dari bulan Maret sampai dengan Juni 2022. Penelitian menggunakan Rancangan Acak Kelompok dengan percobaan faktorial 3 x 4 yang terdiri dari 3 ulangan. Faktor Pertama adalah urea (N) yang terdiri dari 4 taraf yaitu N0 (tanpa perlakuan), N1 (200 gram/L/Polybag), N2 (250 gram/L/Polybag), dan N3 (300 gram/L/Polybag). Faktor kedua adalah kotoran sapi (K) yang terdiri dari 3 taraf yaitu K0 (tanpa perlakuan), K1 (200 gram/polybag) dan K2 (250 gram/polybag). Hasil penelitian pada perlakuan pupuk urea dan pupuk kotoran sapi pada parameter tinggi, diameter batang, dan jumlah helai daun tanaman 45 HSP, 75 HSP dan 105 HSP tidak berpengaruh nyata . Interaksi pupuk Urea dan pupuk. Kotoran Sapi berpengaruh nyata pada paremeter tinggi tanaman dan diameter batang umur 105 HSP untuk interaksi keduanya disarankan menggunakan dosis pemupukan N2: 250 gram/L/Polybag dan K1: 200 gram/polybag

Kata Kunci : Elaeis, Nitrogen, Organik
Pengaruh Aplikasi ZPT Air Kelapa dan Pupuk ZA Terhadap Pertumbuhan dan Produksi Tanaman Bawang Merah (Allium ascalonicum L.)
Authors: Oksilia Oksilia , Krisman Penyabar Halawa Meiman , Jali Syafran , Muzar Missdiani
Published: February 2023

Bawang merah merupakan salah satu bahan yang banyak digunakan sebagai penyedap masakan yang produksi terus menurun akibat luasan areal panen yang mengalami degradasi unsr hara akibat penggun

Bawang merah merupakan salah satu bahan yang banyak digunakan sebagai penyedap masakan yang produksi terus menurun akibat luasan areal panen yang mengalami degradasi unsr hara akibat penggunaan pupuk kimia secara berlebihan. Untuk itu diperlukan pemupukan tepat dosis dan pemberian zat pengatur tumbuh untuk menambah kualitas lahan. Penelitian ini bertujuan untuk mengetahui pengaruh ZPT air kelapa dan pupuk ZA pada pertumbuhan serta produksi tanaman bawang merah. Penelitian ini dirancang secara Rancangan Acak Kelompok (RAK) factorial dengan 2 faktor yaitu konsentrasi air kelapa (50%, 75%, 100% dan pupuk ZA (200 kgha-1, 400kg ha-1, dan 600 kgha-1).  Hasil penelitian menunjukkan bahwa Pemberian ZPT air kelapa dan pupuk ZA berpengaruh nyata terhadap pertumbuhan tanaman bawang merah. Konsentrasi Air kelapa terbaik yaitu 75% dan pupuk ZA dengan dosis 400 kg ha-1 secara nyata meningkatkan tinggi tanaman, jumlah daun, diameter umbi, serta berat basah umbi rumpun-1.

aan pupuk kimia secara berlebihan. Untuk itu diperlukan pemupukan tepat dosis dan pemberian zat pengatur tumbuh untuk menambah kualitas lahan. Penelitian ini bertujuan untuk mengetahui pengaruh ZPT air kelapa dan pupuk ZA pada pertumbuhan serta produksi tanaman bawang merah. Penelitian ini dirancang secara Rancangan Acak Kelompok (RAK) factorial dengan 2 faktor yaitu konsentrasi air kelapa (50%, 75%, 100% dan pupuk ZA (200 kgha-1, 400kg ha-1, dan 600 kgha-1).  Hasil penelitian menunjukkan bahwa Pemberian ZPT air kelapa dan pupuk ZA berpengaruh nyata terhadap pertumbuhan tanaman bawang merah. Konsentrasi Air kelapa terbaik yaitu 75% dan pupuk ZA dengan dosis 400 kg ha-1 secara nyata meningkatkan tinggi tanaman, jumlah daun, diameter umbi, serta berat basah umbi rumpun-1.
Organik Hayvansal Ürünlerin Yağ Asidi Kompozisyonları
Authors: Yücel Ceyhun
Published: February 2023

Bu derlemede organik ve konvansiyonel (geleneksel) koşullarda yetiştirilen hayvanlardan elde edilen ürünlerin (et, süt, yumurta vb.) insan sağlığı için esansiyel nitelik taşıyan doymamış yağ asitleri (MUFA, PUFA) içeriklerinin karşılaştırılması amacıyla hazırlanmıştır. Hayvansal ürünlerin doymamış yağ asidi içerik ve miktarları ürün kalitesini ve besleyiciliğini yansıtmakla birlikte organik hayvansal ürünlerin yetiştirme sistemlerine (ekstansif) bağlı olarak daha fazla doymamış yağ asitleri içerdiği ve buna bağlı olarak daha kaliteli ve besleyici olduğu belirlenmiştir. Sürdürülebilir tarım ve hayvancılığın temel taşı olan organik tarım ve bunun ayrılmaz bir parçası olan organik hayvancılık, doğal kaynakları etkin kullanan, çiftlik hayvanlarına doğal davranışlarının tüm hallerini göstermelerine izin veren, organik yemlerle beslenen, verimi artırmak amacıyla hormon, antibiyotik vb. katkı maddeleri kullanılmayan, tüketicilere ürün miktarı ile birlikte daha sağlıklı ürünler sunmayı amaçlamış, çevre dostu bir üretim modelidir.
Yonca (Medicago sativa L.) Çeşitlerinin Farklı Sıcaklıklarda İnce Tabaka Kurutulmasının Matematiksel Modellenmesi
Authors: Taşova Muhammed , Polatcı Hakan , Özkurt Mahir
Published: February 2023

Bu çalışmada, Frigos, Bilensoy, Nimet ve Prosementi yonca çeşitleri konvektif kurutucuda (50, 60 ve 70Â°C) ve açıkta (güneşte) kurutularak ürünlerin ortalama kuruma süreleri belirlenmiştir. Bununla birlikte kurutma işlemlerinin kontrol edilmesinde ve ürüne özgü yeni kurutucuların geliştirilmesinde önemli olan en uygun ince tabakalı kuruma modelleri belirlenmiştir. Kurutma işlemlerinde ürün nemi içeriği yaş baza göre %10 seviyelerine kadar kurutulmuştur. Belirtilen çeşitlere ait ilk nem içerikleri yaş baza göre sırasıyla; %76,20, 75,88, 76,13 ve 75,07 olarak belirlenmiştir. Kurutma işlemlerinde, kurutma yöntemi ve sıcaklıklarının ortalama kuruma sürelerini değiştirdiği tespit edilmiştir. Belirlenen en uzun kuruma süreleri güneşe serilerek kurutulan Frigos çeşidinde tespit edilmiştir. Frigos çeşidi, etüvde 50, 60 ve 70Â°C sıcaklık değerlerinde kurutulduğunda belirlenen ortalama kuruma süreleri 11, 10 ve 6 saat olarak belirlenmiştir. Süreye bağlı uzaklaşan nem oranları belirlenerek, ince tabakalı kurutma modellerinde işlenmiş ve kuruma eğrilerini en iyi tahmin eden matematiksel model tespit edilmiştir. Eğriler oluşturulurken literatürde yaygın olarak kullanılan Page, Midilli, Yağcıoğlu modelleri kullanılmıştır. Tüm modellerde kabul edilebilir güvenilirlik değerleri olarak bulunurken, modelleri arasında kararlılık değeri (R2) en yüksek ise Midilli eşitliğinde bulunmuştur.
In ovo Feeding Technology for Optimization of Incubation and Hatching in Broiler Chickens
Authors: Tainika Brian , Şekeroğlu Ahmet
Published: February 2023

This paper provided a brief account of the need of in ovo feeding technology for efficient incubation and hatching as driven by the current and projected poultry production figures. After substantial laboratory experiments in the early 1980s, in ovo vaccination technology became applicable in the commercial broiler hatcheries. The scientific theories that enabled the use of in ovo vaccination facilitated the process of injecting the various nutrient composition into broiler eggs/embryo (in ovo feeding) considering the injection site and the stage of embryonic development. Some studies of in ovo feeding have found scientifically positive effects on incubation properties but they remain insufficient at the commercial level thus, the adoption of the application is very slow compared to other embryo management techniques. Therefore, continuous studies on the best nutrient compositions, combinations, and concentrations are required for the commercial use of in ovo feeding technology.
O uso do verbo ΜΙΑIΝΩ em Estesícoro 19 e o páthos homérico evocado
Authors: Canazart Gabriela
Published: February 2023

É consenso entre os comentadores que o fragmento 19 de Estesícoro (DAVIES; FINGLASS, 2014) faz alusões à Ilíada de Homero. Os focos das discussões dessas alusões são a caracterização de Gerião, que porta armas tal como os heróis iliádicos, e, principalmente, o símile da papoula, que, apesar da tradicionalidade da comparação dos heróis com plantas, parece retomar o contexto e o páthos especificamente homéricos. O presente artigo propõe-se a expandir essas discussões por meio da análise dos usos do verbo μιαίνω, tanto no fragmento quanto na Ilíada, e discutir como o poema estesicoreu recupera os contextos homéricos do uso verbal e, por meio deles, gera empatia por Gerião no receptor.
FATORES QUE DIFICULTAM A APRENDIZAGEM DA LÍNGUA INGLESA NA FASE ADULTA NO CURSO LIVRE DE INGLÊS
Authors: Sousa Maria Goretti Guerreiro Silva de , Gomes Ana Karina de Almeida , Chena Ana Eugenia Gonzalez
Published: February 2023

Neste século moderno, ter domínio de um idioma significa crescimento, amadurecimento, e mais desenvoltura para acompanhar as mudanças universais, no entanto, muitas pessoas ainda apresentam dificuldades em apreender outra língua. Analisado o desempenho em várias faixas etárias, percebe-se que ocorrem no início da fase adulta. Diante dessa problemática, este trabalho teve como objetivo geral, conhecer o processo de aquisição e aprendizagem de uma língua estrangeira; os objetivos específicos foram: observar a diferença entre a aquisição e a aprendizagem de uma segunda língua na fase adulto do indivíduo; considerar a significância em aprender a língua inglesa; reconhecer os principais fatores que dificultam esse tipo de aprendizagem, no período do Curso Livre de Inglês; realizar uma pesquisa na turma do primeiro semestre, de Língua Inglesa do Centro de Línguas Estrangeiras do Ceará (CLEC); averiguar a interação no ambiente de aprendizagem e o processo de aprendizagem da LI. No percurso metodológico se usou a pesquisa qualitativa, realizou-se estudos teóricos em relação a fase adulta, no que diz respeito a aquisição, e o modo de aprendizagem da LE. No que concerne aos resultados da pesquisa, identificou-se alguns fatores, em que se considera responsáveis por algumas dessas dificuldades, manifestadas no início da aprendizagem na fase adulta, e que na LI, maior parte dos alunos não tem rotina programada para estudar.
A IMPORTÂNCIA DA INTEGRAÇÃO DO FARMACÊUTICO CLÍNICO EM UMA UNIDADE DE TERAPIA INTENSIVA (UTI): UMA REVISÃO INTEGRATIVA
Authors: Cavalcante Malena Gadelha , Arruda Késsia Cristiane de Oliveira , Sousa Maria Alana Lima de , Francelino Eudiana Vale
Published: February 2023

A evolução do farmacêutico clínico fez com que aumentassem as responsabilidades ligadas diretamente ao paciente, com isso, criaram-se as resoluções de diretoria colegiada (RDC) 585/13 e a RDC 675/19. Estas regulamentam as atribuições do farmacêutico clínico em unidades de terapia intensiva e dá outras providências. Diante disso, o objetivo do presente estudo foi realizar uma revisão integrativa sobre a importância da integração do farmacêutico clínico em Unidades de Terapia Intensiva de 2015 a 2020. Foi realizada uma busca nas bases de dados: Scientific Electronic Library Online (SciELO) e "National Center for Biotechnology Information (Pubmed) com os descritores “Pharmacy Service”, AND “Intensive care units" AND "Pharmacist” entre julho a setembro de 2020, usando os seguintes filtros: publicações dos últimos 5 anos; texto completo livre e idiomas português, inglês e espanhol.  No total foram encontrados 34 artigos, destes, foram excluídos 24 artigos, devido duplicidade, texto limitado e temas não relacionados com o estudo. Apenas 8 artigos se enquadraram nos critérios de elegibilidade. Os artigos tiveram em comum os seguintes pontos: reconciliação medicamentosa, avaliação da farmacoterapia, identificações de reações adversas, diminuição do tempo de internação e problemas relacionados a medicamentos (PRMs). As principais PRMs encontradas incluíram erros de medicação, eventos adversos e interações medicamentosas. Aponta-se que as intervenções farmacêuticas na UTI influenciam positivamente na morbidade, mortalidade e custos com cuidados de saúde. Diante disso, a integração do farmacêutico em UTIs é de suma importância tanto para a segurança do paciente, bem como, para redução de custos nessas unidades.
HIDROTERAPIA NO AMBIENTE DE TERAPIA INTENSIVA NEONATAL NO CONTEXTO DO CUIDADO INTENSIVO HUMANIZADO
Authors: Carvalho Dayanne Moreira de , Nunes Natália Paz , Gadelha Raimunda Rosilene Magalhães , Carvalho Karine Maria Martins Bezerra
Published: February 2023

O objetivo deste estudo foi analisar as evidências científicas a respeito da relevância da hidroterapia no ambiente de terapia intensiva neonatal no contexto do cuidado intensivo humanizado. O presente estudo foi idealizado como método a revisão integrativa da literatura. Após o estabelecimento da questão norteadora, cinco bases de dados foram utilizadas como fonte de levantamento dos estudos: SciELO, MEDLINE, LILACS e o Portal de periódicos da CAPES. Durante a busca nas bases de dados foram localizados 28 estudos, onde apenas 06 artigos corresponderam aos critérios de inclusão do estudo. Dos seis (06) artigos selecionados, 66,6% (n=04) foram publicados no idioma português. Quanto aos tipos de delineamentos dos estudos, um estudo não foi experimental, caracterizando-se por ser retrospectivo. Com relação ao período de publicação do estudo, foi verificado que 62,5% (n=5) dos artigos localizados foi publicado nos últimos 5 anos. Sendo que 75% (n=6) dos estudos localizados foram publicados no idioma português. Os estudos analisados indicam que imersão em água aquecida promove melhora dos parâmetros fisiológicos, dos sinais de dor e da qualidade de sono aos recém-nascidos estáveis no ambiente de terapia intensiva. A fisioterapia aquática pode ser indicada para o paciente recém-nascido como um recurso não farmacológico que promove alívio, relaxamento e conforto, contribuindo para a redução dos efeitos nocivos do tratamento intensivo dentro do ambiente de terapia intensiva.
İş Bağlılığı ve İş Bağımlılığının İşyerinde Haset, Gıpta ve Bağlanma Stilleri ile Olan İlişkisi
Authors: MÜCEVHER Muhammet Hamdi , GÜL Tolga
Published: February 2023

Bu çalışmada, haset ve gıptanın bağlanma stilleri ile olan ilişkisi ve bu ilişkilerin iş bağlılığı ve iş bağımlılığı üzerindeki etkisi araştırılmıştır. İnsanların haset ve gıpta duygularının kendilerine yönelik değer yargıları ile ilişki içerisinde olması, bağlanma stilleri ile ilişki olabileceği ve bu durumun da iş bağlılığı ve iş bağımlılığını etkileyeceği düşünülmektedir. Ayrıca araştırmada, iş bağlılığının olumlu, iş bağımlılığının ise olumsuz bir tutum olması literatür ve bulgular eşliğinde vurgulanmaya çalışılmıştır. Bu amaç doğrultusunda, araştırma 358 beyaz yakalı işgören ve yöneticiye uygulanmıştır. Araştırma bulguları incelendiğinde, kaygılı bağlanma, iş bağlılığını ve gıptayı negatif yönde etkilerken, iş bağımlılığını ise pozitif yönde etkilemektedir. Gıptanın ise iş bağlılığını pozitif yönde etkilediği bulunmuştur. Ayrıca kaygılı bağlanma ile iş bağlılığı arasındaki ilişkide, gıptanın tam aracılık etkisinin olduğu da araştırma bulgularındandır.
Utilisation of trypan blue dye as a diagnostic tool during cataract surgery in patients suspected to have pseudoexfoliation syndrome
Authors: Lien Tiffany N. , da Silva Helio Vinicius Neves , Ifantides Cristos
Published: February 2023

Pseudoexfoliation syndrome (PEX) is diagnosed clinically by slit-lamp examination, but classic examination findings can be subtle or absent in the early disease. Trypan blue dye can be used as a diagnostic tool during cataract surgery in patients suspected to have PEX.
Acute epidural vertex hematoma with good hemostasis using delayed surgery after monitoring of coagulation and fibrinolytic parameters: A case report
Authors: Kotani Saki , Murakami Nobukuni , Doi Tomoyuki , Ogawa Takahiro , Hashimoto Naoya
Published: February 2023

Background:

The appropriate timing and method of surgery for vertex epidural hematoma (VEDH) are uncertain due to the presentation and slow symptomatic exacerbation caused by bleeding from a venous origin involving the injured superior sagittal sinus (SSS). Coagulation and fibrinolytic disorders that occur after traumatic brain injury also worsen bleeding. For these reasons, it is challenging to decide the surgical procedure and timing of surgery.

Case Description:

A 24-year-old man involved a car accident and was transported to our emergency department. He was unconscious but not lethargic. Computed tomography showed VEDH overlying the SSS, and hematoma increased temporarily. Due to abnormal coagulation and fibrinolysis at admission, he underwent intentionally delayed surgery after control of coagulation and fibrinolysis. Bilateral parasagittal craniotomy was chosen to ensure hemostasis from the torn SSS. The patient improved without complications and was discharged with no neurological deficit. This case indicates that this surgical strategy is favorable for VEDH with slow symptomatic progression.

Conclusion:

VEDH is mostly caused by bleeding from the injured SSS secondary to diastatic fracture of sagittal suture. Intentionally delayed surgical intervention using bilateral parasagittal craniotomy after stabilization of coagulation and fibrinolysis is favorable for prevention of further hemorrhage and good hemostasis.
Middle meningeal artery embolisation: The review of a new treatment for chronic subdural hematomas
Authors: Msheik Ali , Fares Youssef , Mohanna Mohammad , Aoude Ahmad , Shkeir Mohamad , Chehade Feras , Kanj Ali , Mohanna Assaad
Published: February 2023

Background:

This is a literature review aiming to provide an update about the recent findings related to the efficacy of middle meningeal artery embolization (MMAE) in the treatment of chronic subdural hematomas (cSDHs), comparison with conventional therapy and deduction of the current recommendations and indications.

Methods:

The literature is reviewed using a search through the PubMed index using keywords. Studies are then screened, skimmed, and thoroughly read. 32 studies fulfilled the inclusion criteria and are included in the study.

Results:

Five indications for the application of MMA embolization (MMAE) are deducted from the literature. The usage as a preventive measure after surgical treatment of symptomatic cSDHs in patients with a high risk of recurrence and the usage as a standalone procedure has been the most common reasons for indication of this procedure. Rates of failures for the aforementioned indications have been 6.8% and 3.8%, respectively.

Conclusion:

The safety of MMAE as a procedure is regarded as a general theme in the literature and can be considered for future applications. Usage of this procedure in clinical trials with more patient segregation and timeframe assessment relative to surgical intervention are recommendations of this literature review.
Uncommon metastases to the brain: Frontal lobe myoepithelial carcinoma
Authors: Chong César , Wong-Achi Xavier , Pozo Marlon , Pico Janio
Published: February 2023

Background:

Myoepithelial tumors have been widely described as a rare form of salivary gland neoplasm, although currently soft-tissue phenotypes have also been identified. These are tumors composed entirely of myoepithelial cells that exhibit a dual epithelial and smooth muscle phenotype. The occurrence of myoepithelial tumors within the central nervous system is also extremely rare, with only a few cases reported. Treatment options include surgical resection, chemotherapy, radiotherapy, or a combination of these approaches.

Case Description:

The authors present a case of soft-tissue myoepithelial carcinoma with an unusual brain metastasis, rarely described in the literature. The purpose of this article is to present an update on the diagnosis and treatment of this pathology when affecting the central nervous system, through the review of the current evidence.

Conclusion:

However, despite complete surgical resection, there is about a significative high rate of local recurrence and metastasis. Careful patient follow-up and staging is essential for better characterization and understanding of this tumor’s behavior.
Recovery of volitional movement with epidural stimulation after “complete” spinal cord injury due to gunshot: A case report and literature review
Authors: Gupta Rishabh , Johnson Reid , Samadani Uzma
Published: February 2023

Background:

Epidural spinal cord stimulation (eSCS) restores volitional movement and improves autonomic function after nonpenetrating and traumatic spinal cord injury (SCI). There is limited evidence of its utility for penetrating SCI (pSCI).

Case Description:

A 25-year-old male sustained a gunshot wound (GSW) resulting in T6 motor/sensory paraplegia and complete loss of bowel and bladder function. Following eSCS placement, he regained partial volitional movement and has independent bowel movements 40% of the time.

Conclusion:

A 25-year-old pSCI patient who, following a GSW resulting in T6-level paraplegia, sustained marked recovery of volitional movement and autonomic function following eSCS placement.
Usefulness of Intraoperative ultrasound for cortical dysplasia type I treatment - A single-center experience
Authors: Sufianov Albert , Simfukwe Keith , Iakimov Iurii A. , Sufianov Rinat A. , Rassi Marcio S. , Mastronardi Luciano , Borba Luis A. B. , Campero Alvaro , Rangel Carlos Castillo , Baldoncini Matias
Published: February 2023

Background:

Focal cortical dysplasias (FCD) cause a subgroup of malformations of cortical development that has been closely linked to cause drug intractable epilepsy. Attaining adequate and safe resection of the dysplastic lesion has proved to be a viable option to archive meaningful seizure control. Of the three types of FCD (types I, II, and III), type I has the least detectable architectural and radiological abnormalities. This makes it challenging (preoperatively and intraoperatively) to achieve adequate resection. Intraoperatively, ultrasound navigation has proven an effective tool during the resection of these lesions. We evaluate our institutional experience in surgical management of FCD type I using intraoperative ultrasound (IoUS).

Methods:

Our work is a retrospective and descriptive study, where we analyzed patients diagnosed with refractory epilepsy who underwent IoUS-guided epileptogenic tissue resection. The surgical cases analyzed were from January 2015 to June 2020 at the Federal Center of Neurosurgery, Tyumen, only patients with histological confirmation of postoperative CDF type I were included in the study.

Results:

Of the 11 patients with histologically diagnosed FCD type I, 81.8% of the patients postoperatively had a significant reduction in seizure frequency (Engel outcome I-II).

Conclusion:

IoUS is a critical tool for detecting and delineating FCD type I lesions, which is necessary for effective post-epilepsy surgery results.
Dürtme Kımıldat: Enerji Etiketlemesi Düzenlemesi
Authors: ÖZDEMİRAY Sema Müge
Published: February 2023

Dürtme yaklaşımı; bireylerin davranışlarının, tercihlerinin ve kararlarının tahmin edilebilir bir şekilde yönlendirilmesi amacıyla son dönemde hem kamu politikası uygulayıcılarının başvurduğu hem de akademik camianın ilgi duyduğu önemli politika araçlarından bir tanesidir. Ancak aynı zamanda bireylerin yönlendirmenin amacı ile ilgili farkındalığının olmaması, manipülasyon riski taşıması ve bireylerin seçmeme ya da yanlış yapma özgürlüklerini kısıtlama olasılığı nedeniyle çokça eleştirilmektedir. Bu sebeple dürtme yaklaşımına alternatif yaklaşımlar akademik çalışmalarda tartışılmaktadır. Çalışmanın temelini oluşturan ve Adam Oliver tarafından önerilen kımıldatma yaklaşımı da bunlardan bir tanesidir. Kımıldatma yaklaşımı; arzu edilen amaca ulaşmada malların, hizmet ve süreçlerin talep tarafını oluşturan bireylere değil arz tarafını oluşturan özel sektörün eylemlerine odaklanılmasını, bu eylemlerin davranışsal ilkeler ışığında düzenlenmesini önermektedir. Çalışmanın amacı da enerji verimliliğini sağlama noktasında Türkiye’de yürürlükte olan enerji etiketlemesi düzenlemesini bir kımıldatma örneği olarak irdelemektir. Çalışmada enerji etiketleri üzerinde kullanılan renklerin tercihlerinde, enerji sınıflandırılmasında gerçekleştirilen değişimde, değişimin zamanında başvurulan davranışsal ilkeler ortaya konmuştur.
Kreatywność nauczyciela w pracy z dziećmi ze specjalnymi potrzebami edukacyjnymi
Authors: Miłek Katarzyna
Published: February 2023

Wśród standardów kompetencji nauczycielskich jest kreatywność nauczyciela, polegająca na zdolności do twórczego podchodzenia do problemów i trudności, zdolności do innowacyjności, oryginalności, skłonności do inicjatywy. Artykuł jest analizą tej kompetencji jako nieodzownej w pracy nauczyciela, który jest odpowiedzialny za proces kształcenia dzieci ze specjalnymi potrzebami edukacyjnymi. Kompetencja ta wyzwala motywację wewnętrzną dziecka poprzez interesujące zajęcia, stosowane metody, wzmaga motywację do uczenia się, pasję do poznawania i pokonywania trudności.
Solid-state Graft Polymer Electrolytes with Conductive Backbones and Side-chains for Lithium Batteries
Authors: Zeng Guangjian , Dai Shuqi , Chen Xiupeng , Qiu Lu , Kong Xian , Huang Mingjun , Wen Tao
Published: February 2023

Graft polymers have been widely investigated as solid polymer electrolytes (SPEs) in the past decades. However, the presence of insulating backbones in the conventional graft polymers damps the overall Li+ conductivity and transport number (tLi+). Herein, a series of polycarbonates (PCs) possessing ethylene oxide (EO) side-chains were designed and synthesized through ring-opening polymerization (ROP), and their ionic conductivities were evaluated as SPEs with LiTFSI. The synergy of conductive backbones and side-chains gives a high tLi+ value of 0.67, while having an ionic conductivity of 210-5 S cm-1 at 30 C. This work provides new insights into the development of high-performance SPEs by combining different conductive polymers.
Building a nucleic acid nanostructure with DNA-epitope conjugates for a versatile electrochemical protein detection platform
Authors: Gurukandure Asanka , Somasundaram Subramaniam , Kurian Amanda S. N. , Khuda Niamat , Easley Christopher J.
Published: February 2023

The recent surge of effort in nucleic acid-based electrochemical (EC) sensors has been fruitful, and some have even shown real-time quantification of drugs in the blood of living animals. Yet there remains a need for more generalizable EC platforms for the detection of multiple classes of clinically relevant targets. Our group has recently reported a nucleic acid nanostructure that permits simple, economical, and generalizable EC readout of a wide range of analytes (small molecules, peptides, large proteins, or antibodies). The DNA nanostructure is built through on-electrode enzymatic ligation of three oligonucleotides for attachment, binding, and signaling. However, the signaling mechanism predominantly relies on tethered diffusion of methylene blue at the electrode surface, limiting the detection of larger proteins that have no readily available small molecule binding partners. In this study, we adapted the nanostructure sensor to quantify larger proteins in a more generic manner, through conjugating the proteins minimized antibody-binding epitope to the central DNA strand of the nanostructure (DNA-peptide conjugate). This concept was verified using creatine kinase (CK-MM), an important biomarker of muscle damage, myocardial infarction, overexertion/rhabdomyolysis, or neuromuscular disorders where clinical outcomes could be improved with rapid sensing. DNA-epitope conjugates permitted a competitive immunoassay protocol at the electrode surface for quantifying CK protein. Square-wave voltammetry (SWV) signal suppression was proportional to the amount of surface-bound antibody with a limit of detection (LOD) of 5 nM and a response time as low as 3 minutes, and displacement of antibody by native CK-MM protein analyte could also be assayed. CK was quantified from the LOD of 14 nM up to 100 nM, overlapping well with the normal (non-elevated) human clinical range of 3 37 nM, and the sensor response was validated in 98% human serum. While a need for improved DNA-epitope conjugate purification was identified, overall this approach not only allows the detection of a generic protein- or peptide-binding antibody, but it also should facilitate future quantitative EC readout of various clinically relevant protein analytes that were previously inaccessible to EC techniques.
Over 20% 13C Hyperpolarization for Pyruvate Using Deuteration and Rapid SLIC-SABRE in Mictrotesla Fields
Authors: Schmidt Andreas B. , Eills James , Dagys Laurynas , Gierse Martin , Keim Michael , Lucas Sebastian , Bock Michael , Schwartz Ilai , Zaitsev Maxim , Chekmenev Eduard Y. , Knecht Stephan
Published: February 2023

Carbon-13 hyperpolarized pyruvate is about to become the next-generation contrast agent for molecular magnetic resonance imaging of cancer and other diseases. Here, efficient and rapid pyruvate hyperpolarization is achieved via Signal Amplification by Reversible Exchange (SABRE) with parahydrogen through synergistic use of substrate deuteration, alternating, and static microtesla magnetic fields. Up to 22% and 6% long-lasting 13C polarization (T1=3.7±0.25min and T1=1.7±0.1min) is demonstrated for the C1 and C2 nuclear sites, respectively. The remarkable polarization levels become possible due to favorable relaxation dynamics at the microtesla fields. The ultra-long polarization lifetimes will be conducive to yielding high polarization after purification, quality assurance, and injection of the hyperpolarized molecular imaging probes. These results pave the way to future in vivo translation of carbon-13 hyperpolarized molecular imaging probes prepared by this approach.
Decoding Optical Responses of Contact-Printed Arrays of Thermotropic Liquid Crystals Using Machine Learning: Detection and Reporting of Aqueous Amphiphiles with Enhanced Sensitivity and Selectivity
Authors: Wang Fengrui , Qin Shiyi , Acevedo-Velez Claribel , Van Lehn Reid , Zavala Victor , Lynn David
Published: February 2023

Surfactants and other amphiphilic molecules are used extensively in household products, industrial processes, and biological applications, and are also common environmental contaminants; as such, methods that can detect, sense, or quantify them are of great practical relevance. Aqueous emulsions of thermotropic liquid crystals (LCs) can exhibit distinctive optical responses in the presence of surfactants and have thus emerged as sensitive, rapid, and inexpensive sensors or reporters of environmental amphiphiles. However, many existing LC-in-water emulsions require the use of complicated or expensive instrumentation for quantitative characterization, owing to variations in optical responses among individual LC droplets. In many cases, the responses of LC droplets are also analyzed by human inspection, which can miss subtle color or topological changes encoded in LC birefringence patterns. Here, we report an LC-based surfactant sensing platform that takes a step toward addressing several of these issues and can reliably predict concentrations and types of model surfactants in aqueous solutions. Our approach uses surface-immobilized, microcontact printed arrays of micrometer-scale droplets of thermotropic LCs and hierarchical convolutional neural networks (CNNs) to automatically extract and decode rich information about topological defects and color patterns available in optical micrographs of LC droplets to classify and quantify adsorbed surfactants. In addition, we report computational capabilities to determine relevant optical features extracted by the CNN from LC micrographs, which can provide insights on surfactant adsorption phenomena at LC-water interfaces. Overall, the combination of microcontact-printed LC arrays and machine learning provides a convenient and robust platform that could prove useful for developing high-throughput sensors for on-site testing of environmentally or biologically relevant amphiphiles.
Possibilities of dispensary observation in reducing mortality from coronary heart disease
Authors: Boytsov Sergey A. , Provatorov Sergei I.
Published: February 2023

Dispensary observation of patients with coronary artery disease can significantly reduce the likelihood of cardiovascular complications onset. Active outpatient monitoring allows to correct the main risk factors for cardiovascular complications, to estimate the risk of unfavorable cardiovascular events onset and to identificate patients who will get benefit of coronary revascularization. The introduction of a comprehensive assessment of cardiovascular risk and the development of remote monitoring technologies will improve the long-term results of outpatient follow-up of patients with coronary artery disease at high cardiovascular risk.
Comorbid status of patients with hypertension
Authors: Osmanov Esedulla M. , Reshetnikov Vladimir A. , Manyakov Rustam R. , Garaeva Amina S. , Korkmazova Lauriia Kh. , Demenkova Valeriya V.
Published: February 2023

Aim. To establish age and gender characteristics, nosological structure of comorbidity among persons 2099 years with hypertension.
Materials and methods. The study is based on data from 21 514 electronic health records of the population (2099 years old) with hypertension, mean age 63.0 years, 68.2% women. Diseases associated with hypertension with a frequency above 10% were analyzed.
Results. In the sample of people with hypertension, concomitant diseases were detected in 82.7% of cases, 1 disease accompanies 21.0% of the sample with hypertension, 2 diseases 17.9%, 3 diseases 14.0%, 4+ diseases 29.8%. The frequency of association of hypertension with 1 concomitant disease at the 2029 years is 60.8% of cases, at 3039 years 65.1%, at 4049 years 73.9%, at 5059 years 81.1%, 6069 years 85.8%, 7079 years 87.3%, 80+ years 86.2% of cases. Among women with hypertension, the average number of concomitant diseases is higher compared to men (3.47 vs 2.4 cases; p0.001). Among young and middle-aged people, hypertension in most cases is associated with osteochondrosis, osteoarthritis, chronic pancreatitis, gastritis and duodenitis, retinal diseases, thyroid diseases, the female with hypertension accompanied by benign breast disease and menopausal disorders. Hypertension in the elderly is most often associated with cerebrovascular disease, coronary heart disease, diabetes mellitus, senile cataract, but osteochondrosis and osteoarthritis also do not lose their relevance.
Conclusion. The existing system of organization of medical care cannot meet the needs of patients with comorbidity, which indicates the need to reorient medical care towards patient-centered care.
The experience in treatment of dengue fever using antiviral drug riamilovir in the Republic of Guinea (case report)
Authors: Maltsev Oleg V. , Kasyanenko Kristina V. , Zhdanov Konstantin V. , Malyshev Nikolay A. , Kolomoets Elena V. , Konomou Victor K.
Published: February 2023

Dengue fever is classified as one of the most common viral diseases with a transmission mechanism implemented through arthropod vectors. The expansion of of the Aedes aegypti mosquito is leading to a significant increase in the number of cases of dengue fever in more than 100 countries, highlighting the importance of developing and implementing specific prevention and treatment measures. Etiotropic drugs with proven efficacy against the pathogen are not registered, and the use of the vaccine is approved only among seropositive individuals. In this regard, pathogenetic treatment remains the main therapeutic strategy, however, work on the synthesis of antiviral drugs is being actively carried out. Due to the unique functions of non-structural proteins NS3 and NS5 in the viral replication cycle, they have become the main targets for studying the antiviral activity of a number of chemotherapy drugs. Of these proteins, due to the most conserved structure, the NS5 protein is a promising target for inhibition, however, success in obtaining a clinical effect using a number of available antiviral drugs has not been reached. This study describes the positive experience of using the nucleoside analogue riamilovir in the treatment of a patient with dengue fever in the Republic of Guinea.
Pre-exposure prophylaxis of new COVID-19 coronavirus infection with tixagevimab/cilgavimab in adult Moscow patients with primary immunodeficiencies
Authors: Roppelt Anna A. , Lebedkina Marina S. , Chernov Anton A. , Kruglova Tatiana S. , Mukhina Olga A. , Yukhnovskaya Yulia D. , Samedova Farida A. , Mаrkina Ulyana A. , Andrenova Gerelma V. , Karaulov Alexander V. , Lysenko Mariana A. , Fomina Daria S.
Published: February 2023

Background. Primary immunodeficiencies (PIDs), now known as inborn errors of immunity, are a group of inherited diseases caused by defects in the genes that control the immune response. Patients with PIDs have risks of developing a severe course and/or death in COVID-19. Passive immunization with long-acting monoclonal antibodies (MABs) to SARS-CoV-2 should be considered as pre-exposure prophylaxis in patients with PIDs. Tixagevimab/cilgavimab is a combination of MABs that bind to the SARS-CoV-2 spike protein.
Aim. To evaluate the efficacy and safety of pre-exposure prophylaxis of new SARS-CoV-2 infection in PIDs with the combination of tixagevimab/cilgavimab.
Materials and methods. Forty eight patients diagnosed with PIDs were included in the study. Median follow-up after drug administration was 174 days. The total number of confirmed coronavirus infections in patients with PIDs as well as 6 months before and after administration of MAT were assessed.
Results. In the analyzed cohort, the overall incidence of COVID-19 from pandemic onset to MABs administration was 75% (36/48), with 31% (11/36) of over-infected patients having had the infection more than once. The incidence of COVID-19 immediately 6 months before the introduction of tixagevimab/cilgavimab was 40%. All patients who had COVID-19 after pre-exposure prophylaxis had a mild infection. The incidence of COVID-19 6 months after tixagevimab/cilgavimab administration significantly decreased compared to the incidence 6 months before administration (7 and 40%, respectively; p0.001).
Conclusion. The use of tixagevimab/cilgavimab in patients with PIDs is effective as pre-exposure prophylaxis and reduces the risk of severe COVID-19.
HỢP CHẤT STEROID VÀ FLAVONE TỪ THÂN RỄ THIÊN NIÊN KIỆN LÁ LỚN (Homalomena pendula)
Authors: Nguyễn Khánh Thùy Linh , Trần Ngân Thi , Nguyễn Thị Ngọc Trâm , Lê Văn Hậu , Hoàng Thị Như Hạnh , Nguyễn Thị Hoài , Hồ Việt Đức
Published: February 2023

Hợp chất flavone, tangeretin (1), và ba hợp chất steroid: ergosterol peroxide (2), sitoindoside I (3) và stigmasterol (4) đã được phân lập từ thân rễ của cây thiên niên kiện lá lớn (Homalomena pendula). Cấu trúc hóa học của chúng được xác định dựa trên phân tích dữ liệu phổ cộng hưởng từ hạt nhân (1D và 2D NMR) và so sánh với các tài liệu đã công bố. Các hợp chất (1-3) được phân lập lần đầu tiên từ chi Homalomena. Cao chiết n-hexane và ethyl acetate của cây này có hoạt tính ức chế sản sinh NO trên đại thực bào RAW 264.7 kích thích bằng lipopolysaccharide với các giá trị IC50 là 46,80 và 75,52 µg·mL–1.
TẠO DÒNG CÁC GEN MÃ HÓA CHITINASE 42 kDa CỦA Trichoderma asperellum VÀO VECTOR BIỂU HIỆN THỰC VẬT pMYV719 ĐỂ PHỤC VỤ CHUYỂN GEN
Authors: Phùng Thị Bích Hòa , Nguyễn Hoàng Tuệ , Phạm Thị Huyền Trang , Trần Gia Cát Tường , Huỳnh Thị Huyền Trang , Nguyễn Xuân Huy , Nguyễn Hoàng Lộc
Published: February 2023

Trong nghiên cứu này, các gen chitinase mang trình tự peptide tín hiệu như Chi42, syncodChi42-1 và syncodChi42-2 đã được tạo dòng trong vector biểu hiện thực vật pMYV719 và biến nạp thành công vào vi khuẩn Agrobacterium tumefaciens LBA 4404. Trong đó, gen Chi42 là kiểu gen hoang dại từ chủng nấm Trichoderma asperellum SH16. Hai gen syncodChi42-1 và syncodChi42-2 có nguồn gốc từ gen Chi42 đã được tối ưu hóa bộ ba sử dụng để biểu hiện thực vật. Vi khuẩn A. tumefaciens mang các gen chitinase được sử dụng để chuyển gen vào cây lạc (Arachis hypogaea L.) trong các nghiên cứu tiếp theo để cải thiện khả năng kháng nấm bệnh của chúng.
Pentapartitioned Neutrosophic Almost Resolvable and Irresolvable Spaces
Authors: R Radha  , A. Stanis Arul Mary
Published: February 2023

The aim of this paper is to develop many characterizations of Pentapartitioned Neutrosophic (PN) almost resolvable and irresolvable spaces and also the condition under that a PN almost resolvable space becomes a PN baire space. The interrelations between PN almost resolvable spaces and other spaces also are mentioned.
A study on the cross product of fuzzy numbers
Authors: Sudhakar VJ  , Thirunavukkarasu J
Published: February 2023

In fuzzy arithmetic, the multiplication operation based on Zadeh’s extension principle owns several unnatural properties both from theoretical and practical points of view. To overcome some of these shortcomings, a new operation called cross product has been introduced recently. We show the main properties of the cross product. We also present a comparative study of the traditional multiplication and the cross product in geological applications, especially for estimating of resources of solid mineral deposits.
Ideological and Political Teaching Case Design and Research Based on the Course Simulation Electronic Technology Experiment
Authors: Chen Meiyi , Yang Wei , Hao Xi , Long Shunyu , Zhong Pengfei
Published: February 2023

As critical measures to educate and cultivate people’s morality, “Ideology and Politics of Course” has gradually become the focus in actual undergraduate education research in universities. Targeting the single ideological and political education mode and students’ lack of interest in experimental courses, this paper, through various links, including pre-class preview, in-class teaching, and after-class data analysis, takes the common emitter single tube amplifier experiment as an example to organically integrate the excavated ideological and political elements with practical operation and carry out teaching case design and practice; realize the improvement of students’ learning initiative and problem-analysis ability; and achieve the purpose of cultivating people throughout the whole process and in a comprehensive direction.
Processos de contabilidade multicentenários (1581-1762) na Irmandade de Santa Cruz, Braga (Portugal)
Authors: Da Silva Duarte Domingos , Lima Rodrigues Lúcia
Published: February 2023

Os arquivos históricos das organizações religiosas são fontes primárias importantes para a História da Contabilidade (Baños e López-Manjón, 2021, e outros). A Irmandade de Santa Cruz (ISC), de Braga, é uma dessas organizações, já multicentenária e foi escolhida para este estudo. As regras dos seus Estatutos são as fontes analisadas para questionar os processos de contabilidade, no período de 1581-1762. Pretende-se conhecer a informação produzida, seus utilizadores, cargos de administração e perfil pessoal dos irmãos eleitos para os mesmos. Esta análise seguiu a metodologia de investigação qualitativa. Foram evidenciadas como características principais: regras minuciosas e reduzidas expressões contabilísticas; registos e controlo de contas por atividades/recursos; informação destinada aos irmãos da administração. Para eleição destes, era exigido perfil pessoal adequado, omitindo conhecimentos de contabilidade. Os cargos eram exercidos graciosamente, do tipo de “voluntariado pro-bono”.
Municipal accounting reform in Portugal by Costa Cabral and its impact in the 19th Century (1842-1900)
Authors: De Sousa Fernando , Alberto Fernanda , Góis Cristina , Conde Fátima , Marques Maria da Conceiçao , Lira Miguel
Published: February 2023

This study aims to understand the importance and scope of the municipal accounting reform developed from 1842 to 1849 by Costa Cabral, Portuguese Minister of the Kingdom (1842-1846, 1849-1851) and Prime Minister (1849-1851), analysing its content, effective application, the impact it had on Portuguese municipal accounting and how it contributed to a greater link between the local government and the central government. To this end, we present a brief analysis of the economic, social and political context of the 1840s and the transformations then operated at the administrative and fiscal level with an impact on municipal accounting; the literature review regarding municipal accounting, especially from the 19th century; the historical sources used and the methodology adopted; the nature of Costa Cabral's 1849 Instructions on municipal accounting, its application and importance, seeking to detect changes and the factors behind them. We conclude that the Portuguese State, by defining the regulation for itself and for the organizations that depended on it, intervened, innovated and disseminated the accounting transformations carried out with the 1849 Instructions, seeking to integrate municipalities into the national accounting system as a whole, in a clear exercise of power, in a political context of legal imposition and lack of revenues, but also within a cultural and technical context of modernization, rationality and efficiency of municipal services. Submitting municipalities to common procedures and practices, as well as to the same obligations, is a remarkable achievement.
CHOICE OF A RECONSTRUCTION METHOD FOR POSITRON-EMISSION ECG-GATED STUDIES AND ITS EFFECT ON CALCULATED VOLUMETRIC PARAMETERS OF THE LEFT VENTRICULAR FUNCTION AND VISUAL IMAGE QUALITY
Authors: D.Yu. Mosin , A.K. Kondakov , E.N. Moshkova , D.S. Kharina , S.G. Khasanboev , I.A. Znamenskiy , A.V. Butenko
Published: February 2023

Ischemic heart disease is one of the leading causes of mortality in the Russian Federation. Timely diagnosis of this condition allows you to determine the optimal treatment tactics. Positron emission tomography with 18-fluorodeoxyglucose is a method for verifying viable cardiac tissue in patients with myocardial infarction. The methods used for the reconstruction of positron emission tomograms can affect the quantitative indicators of the contractile function of the myocardium.
Materials and methods. The study retrospectively included 12 patients who underwent PET/CT with 18-fluorodeoxyglucose, the results of which were reconstructed using filtered back projection methods and iterative reconstruction, with ECG synchronization and division of ECG R-R intervals into 8, 10 and 16 frames. The obtained images were evaluated visually by two radiologists, and the quantitative parameters characterizing the contractile function of the left ventricular myocardium were compared in pairs.
Results. There were no significant differences in the assessment of quantitative indicators such as end-systolic and diastolic volumes, stroke volume and ejection fraction. However, the iterative reconstruction results show less data scatter than the filtered back projection reconstruction method. In visual analysis, the best quality of reconstructions by iterative methods is noted.
Conclusions. Thus, the recommended method for both visual analysis and quantification is iterative reconstruction, regardless of the number of timing windows used. A spread in the number of used reconstructed fragments of the cardiac cycle in the range of 8-16, commonly used in clinical practice, can be recommended.
THE INFLUENCE OF FEATURES OF THE CLINICAL COURSE, THERAPEUTIC APPROACH ON THE RISK OF DEVELOPMENT AND PROGRESSION OF CARDIOVASCULAR PATHOLOGY IN PATIENTS WITH BRONCHIAL ASTHMA
Authors: V.S. Lesina , I.A. Starodubtseva , V.C. Chulkov , L.V. Vasilyeva , N.A. Ektova , L.A. Ektova
Published: February 2023

The problem of comorbidity is becoming one of the main ones in modern clinical medicine, and the combination of bronchial asthma (BA) and cardiovascular diseases (CVD) is the most common in the general structure. Asthma is currently considered as an allergic disease of the respiratory tract, in which the inflammatory process plays a leading role. CVD is an inflammatory disease where type 2 cytokines often play a protective role. Numerous clinical studies demonstrate the relationship between allergic asthma and the risk of developing CVD, including coronary heart disease (CHD), atrial fibrillation, myocardial hypertrophy, arterial hypertension (AH). Mast cells, eosinophils, inflammatory cytokines, and immunoglobulin (Ig)E accumulate in the lungs of AD patients and in the damaged heart and blood vessels of CVD patients. Many drugs for the treatment of AD have been shown to affect the risk of CVD. Thus, allergic asthma and CVD may have common pathogenetic mechanisms. There is evidence that anti-asthma drugs have therapeutic potential in some CVDs.