bluuebunny/crossref_metadata_2025 huggingface dataset:
Expression and predictive functional profiles on MicroRNAs data in Vascularized Composite Allotransplantation Acute Rejection
Authors: Fang Yuan , Li Haibo , Chen Jingting , Xiong Yao , Li Xu , Sun Binbin , Li Shengli , Zhou Jianda , Wang Shoubao
Published: May 2022

Aim: To investigate the mechanisms of acute rejection for vascularized composite allotransplantation (VCA) using microRNAs (miRNAs) differential expression in a VCA animal model.Methods: Three brown Norway rats were used as transplant donors and three Lewis rats as VCA receptors. The changes were divided into different stages before and after transplantation in Lewis rats. The appearance changes of all subjects were recorded. Also, histological evaluations were performed on all recipients, and the microRNAs expression was analyzed when acute immune rejection occurred. Then, GO and KEGG Pathway analyses were employed to predict miRNA targets. Finally, differentially expressed miRNAs were detected by RT-qPCR.Results: Compared to pre-operation, 22 miRNAs were screened for significantly different expressions. Among them, nine were upregulated and 13 were downregulated in skin tissues. The RT-qPCR results revealed that rno-miR-340-5p and rno-miR-21-5p were significantly upregulated and enriched in the PI3K-Akt signaling pathway. Moreover, rno-miR-145-5p and rno-miR-195-5p were significantly downregulated, and most of their target genes were enriched in the Hippo signaling pathway. The histological evaluations showed that, after VCA, the skin tissue presented severe acute rejection.Conclusion: Overall, the miRNAs rno-miR-340-5p, rno-miR-21-5p, rno-miR-145-5p, and rno-miR-195-5p were significantly regulated during VCA acute rejection. These miRNAs are potential biomarkers for objective, early, and minimally invasive rejection diagnosis.
Evaluating plant micronutrient retention using an electric potential around the root zone in Rice (Oryza sativa L.) by using iron as an index ion
Authors: Senevirathne Gayathree I. , Chathurika J. A. S. , Gunwardana Manju , Siriwardhana Asitha S. , purasinhala Kosala
Published: May 2022

Deficiency in micronutrients lead to poor health and performance in plants and hidden hunger in many developing countries. Unavailability of micronutrients around the root zone is a major reason accounting for poor performance of crops. Especially, in rice, retention of plant nutrients is challenging due to water logged conditions and adding electric potential to retain nutrients would be a beneficial method to retain micronutrient around the root zone. Therefore, this study was designed to evaluate the effect of direct electric potential (EP) in retaining soil nutrient around the root zone using iron as an index ion. The experimental setup consisted of two concentric iron mesh pots, inner pot connected to the negative end and outer pot connected to the positive end. An electric potential of 5.0 V was supplied with the direct current of 0.1 A for 8 hours per day. Soil was characterized for available iron content around three zones at the time of panicle initiation and time of harvest using ICPMS plant growth and performance was measured. Soil-available Fe content was higher around the negative electrode than the positive electrode at the time of panicle initiation. Plant height, above ground biomass, and paddy yield were significantly lower in WEP plants than the NEP plants (P < 0.05). WEP plants showed a 45% reduction in paddy yield compared to the NEP plants. Results confirms that iron provided in the presence of an electric potential increases the iron concentration around the root zone and enhances the Fe absorption. This underpins the use of electric potential to retain micronutrients especially, cations around the root zone ultimately enhancing their availability for plants.
Evaluation and Characterization of Indigenous Rice (Oryza sativa L.) Landraces Resistant to Brown Planthopper Nilaparvata lugens (Stål.) Biotype 4
Authors: Roy Debashis , Biswas Abhisek , Sarkar Sukamal , Chakraborty Gautam
Published: May 2022

Evaluation and identification of resistant donors for brown planthopper (BPH) Nilaparvata lugens (Stål.), an economically important insect pest of rice, is a continuous process to develop new resistant rice varieties. However, several rice landraces of north-eastern India are not yet characterized for BPH resistance. In the present study, a set of 218 rice landraces were screened in both greenhouse and open-field conditions for three consecutive years, and thereafter forty selected promising entries were explored to evaluate their phenotypic and genotypic reactions against BPH biotype 4. Based on phenotypic evaluations, 5 landraces were identified as resistant, while 31 were moderately resistant, and grouped under the major cluster I and II, respectively, in a circular dendrogram. Antixenosis and antibiosis studies of these landraces divulged that, compared to the susceptible check variety, resistant landraces exhibited the lowest feeding rate, survival, and nymphal and adult settling, but higher frequency of unhatched eggs of BPH. Un-infested resistant landraces registered higher levels of ascorbic acid, oxalic acid and crude silica, however, elevated levels of total free amino acid, potassium and crude silica were observed under BPH herbivory. During the analysis of genetic diversity through 21 BPH resistance gene-linked SSR markers, the selected landraces were categorized into five major clusters at 10 unit distance by the scale of similarity. Most of the resistant landraces were grouped under the major cluster IV revealing their similar genetic history, whereas some were grouped with moderately resistant landraces displaying their genetic variation. The present study focuses on identifying new donors having BPH resistance resources which could be useful in genomic studies for the development of BPH biotype 4 resistant rice varieties.
Exploring destination image in the Egyptian context: a qualitative study
Authors: Shazly Rana Essam Sayed
Published: May 2022

This paper summarizes the arguments within the scientific discussion on destination image. This research aims to investigate the destination image as perceived by tourists to Egypt, the factors shaping this image, and how this affects tourists' behavioral intentions. Also, it aims to empirically design a conceptual framework of the main antecedents and outcomes of destination image in the Egyptian context. This study employs an exploratory research design. Twelve in-depth online interviews were conducted with international tourists who have been to Egypt in the last 3 years. Egypt was chosen as the setting of this research due to different reasons, particularly the lack of research examining destination image in MENA region and the high dependence of Egypt's economy on tourist income (contributing by 20% to the annual GDP of Egypt). The study results show the importance of examining the three dimensions of destination image: cognitive image, affective image, and conative image. The main drivers of destination image were identified and presented in a single framework that entails tourist motivations, memorable tourism experience, and tourist harassment as antecedents to the destination image. In turn, that affects tourists' behavioral intentions, with the moderating role of previous experience and gender. Although examining tourist harassment was not greatly emphasized in earlier literature, the results of this study suggested that it has a major influence on destination image. Also, memorable experiences have greatly shaped the perceived image of Egypt. The results have shed light on the importance of assessing the difference between first-time visitors and repeaters in the relationship between destination image and future behavior. Theoretical and practical recommendations were provided for tourism in Egypt based on the study findings.
Summer Mechanical Hedging to Prune Eight Cider Apple Cultivars
Authors: Kendall Aidan , Alexander Travis R. , LaHue Gabriel T. , Miles Carol A.
Published: May 2022

Mechanical hedging was evaluated at Washington State University Northwestern Washington Research and Extension Center, Mount Vernon, WA, in 2019 and 2020 on eight cider apple (Malus ×domestica) cultivars with four bearing habits: tip—Golden Russet, Harrison; spur—Brown Snout, Cap of Liberty; semispur—Tom Putt, Campfield; and crab—Puget Spice, Hewe’s Virginia Crab. Trees were planted on ‘Geneva 935’ (Malus hybrid) rootstock in one replicate block in 2014 and the second replicate block in 2016 and the central leader of all trees was headed in 2017 to equalize tree size and stage of development. Summer hedging was carried out on all cultivars on 16 July in 2019 and 7 July in 2020. The response of different cultivars was evaluated both years by measuring canopy area removed, shoot biomass removed, and fruit removed, and the amount of time to hedge was measured. Additionally, fruit diameter and fruit yield per tree were measured at harvest both years, and fruit weight was measured at harvest only in 2020. The hedger traveled at an average speed of 1.32 mph; it took 6 seconds on average to hedge both sides of one tree when in-row spacing was 6 ft and took 1.25 minutes to maneuver around the end of a row. The estimated time to hedge 1 acre was 1.45 hours when the hedger traveled at 116 ft/min and the orchard had 10 rows spaced 12 ft apart. Biomass removed on an area and weight basis was less in 2020 than in 2019, whereas yield per tree was 2.6 times greater in 2020 than 2019, and cultivars within a bearing habit differed in these responses to hedging both years. Fruit damaged by the hedger was assessed but observed to be negligible for all cultivars. Yield per tree was negatively correlated with fruit diameter (P < 0.001) and positively correlated with the number of fruit removed per tree (P < 0.025). Further research is needed to assess the long-term effects of hedging on biomass removal, yield, and biennialism to determine whether summer mechanical hedging is a cost-effective and suitable method for managing cider apple orchards.
How a skyrmion can appear both massive and massless
Authors: Wu Xiaofan , Tchernyshyov Oleg
Published: May 2022

When a magnetic skyrmion is modeled as a point particle, its dynamics
depends on the precise definition of the skyrmion center. The
guiding-center position, defined as the first moment of the skyrmion
density, exhibits Thiele’s massless dynamics; position based on the
first moment of magnetization component m_zmz
shows Larmor oscillations characteristic of a massive particle. We show
that, even with the latter definition, the Larmor oscillations may be
absent for certain types of external forces such as adiabatic spin
torque. We offer an alternative mechanical model of a skyrmion featuring
two coupled massless particles.
Wine purchasing decisions in India from a consumer’s perspective: An analysis of influencing factors on the buying behavior
Authors: Ravikumar Anagha , Malik Sushant , Chitnis Asmita , Paul Dipen , K. Mishra Dharmesh
Published: May 2022

This paper analyzed the factors affecting consumers’ purchase intentions and decisions while purchasing wine. The study was performed based on the primary data collected with the help of a survey and a structured questionnaire using convenience sampling. A total of 120 respondents above 21 years old across India who were wine consumers and likely to purchase wine were the study population. Exploratory factor analysis, confirmatory factor analysis, descriptive analysis, and cluster analysis were the main methods used to analyze the data. The information gathered was subjected to further quantitative analysis using SPSS. Kaiser-Meyer-Olkin Measure (KMO) of sampling adequacy was 0.759, and Cronbach’s alpha was 0.817 indicating high reliability of the study. Factor analysis brought out six essential factors affecting the wine purchase decisions of Indian consumers. They are as follows: quality concerns, consumption preferences, consumption deterrents, consumption reasons, social factors, and risk factors. Furthermore, the study found that the purchase intentions of Indian wine consumers are affected by the attitude and awareness of consumers. The cluster analysis further helped to divide the Indian wine market into three segments, i.e., regular consumers comprising 44.2%, non-consumers comprising 29.2%, and occasional consumers comprising 26.7%. A few of the key factors influencing wine purchase are attributes and knowledge of the wine ingredients. In addition, friends and family play an important role in wine purchasing decisions.
Identification of Firm Multiplier of Comparable Firm Valuation Method on Indonesian IPO
Authors: Handaya Andrew , Warganegara Dezie L. , Warganegara Doni S.
Published: May 2022

The aim of this research is to find the relevant valuation measurement, firm multiplier, which is utilized by issuers or underwriters during IPO. This research uses companies that conducted IPO, in the Indonesia Stock Exchange (IDX), within year 2001 to 2007, as the research sample. The hypotheses are developed to find the relevant valuation multiplier. The data are analyzed using One-Sample T Test, Kolmogorov-Smirnov (K-S) Test, and Binomial Test.  The empirical results suggest that there are similarities and differences in valuation results when comparable firm valuation is utilizing different firm multiplier. Among the five methods, i.e. arithmetic mean, median, harmonic mean, closest ROA, and closest TA, the closest TA method performs the worst in Indonesia capital market during 2001-2007. There is no statistical difference between selecting arithmetic mean, median, and harmonic mean methods. The closest ROA method outperforms the arithmetic mean and closest TA methods; however it has similar performance to median and harmonic mean methods.
Analisis Hubungan Profitabilitas Dengan Pergerakan Harga Saham Pada Sektor Usaha PERBANKAN di Bursa Efek Indonesia
Authors: Hartono Hartono , Sihotang Raymundus Parulian
Published: May 2022

Today, stock market activity influenced by many thinks or factors, where could be from internal or external factors company it self. This study analyzed profitability ratio which measured by Net Profit Margin (NPM), Return On Assets (ROA), and Return On Equity (ROE) banking company and the effects to stock market activity. The result showed that only ROE ratio influenced significantly to stock market activity, while others ratio, who is NPM and ROA did not influence significantly to stock market activity.
SPIRITUALITY ANALYSIS AND ORGANIZATIONAL COMMITMENTS IN MURABAHAH WITH INDIVIDUAL ACCURACY AS MEDIATION VARIABLE
Authors: Heykal Mohamad , Herawati Vinola
Published: May 2022

The objective of this study is to analyze the spirituality of work and organizational commitment especially in murabahah financing. This study based on primary data and with explanatory format. This research environment for this study is real in the Islamic banking entitites in Jakarta. The sample of this research is financing staff in Islamic banking in Jakarta and the questioner was distributed to them.  The result of this study is spirituality will influence the decision making process of murabaha financing in the Islamic financial entities in Jakarta with the mediation variable is individual accuracy mediates the relationship between murabaha financing approval processes and commitment to organizational goals.
MOVIMENTO QUÍMICA PÓS 2022: CONSTRUÇÃO DE UM PLANO DE AÇÃO PARA QUE A QUÍMICA E SEUS ATORES IMPACTEM A SUSTENTABILIDADE E SOBERANIA NO BRASIL
Authors: Silva Ingrid , Nascimento Pedro , Lago Rochel , Ramos Mozart , Galembeck Fernando , Rocha Filho Romeu , Teixeira Ana Paula
Published: May 2022

CHEMISTRY POST 2022 MOVEMENT: FORMULATION OF AN ACTION PLAN SO THAT CHEMISTRY AND ITS ACTORS IMPACT THE SUSTAINABILITY AND SOVEREIGNTY IN BRAZIL. Considering the bicentenary of Brazil’s Independence in 2022 and that this year was proclaimed by UNESCO as the International Year of Basic Sciences for Sustainable Development, in mid-2021 the Brazilian Chemical Society (SBQ) launched the “Post 2022 Chemistry Movement – Sustainability and Sovereignty”, with the main goal of promoting different activities so that chemistry contributes for the sustainable development and sovereignty of Brazil in the coming years. One of these activities is the proposal of an action plan, with goals to be achieved by 2030 and 2050. This article describes in detail how this action plan was formulated by a working group, with the help of an advisory council and interviews of 18 professionals from universities, the government, industries, the third sector and other organizations. Mimicking the Agenda 2030 SDGs, the resulting action plan is based on two broad Chemistry Sustainable Development Goals: promoting sustainability through chemistry in basic education, and promoting sustainability in the industry and university through science, technology, innovation, and education (STI&E) in chemistry. After the definition of three driving technological challenges in STI&E, they shall be successively implemented through different actions starting in 2023 yet.
Experimental study on influencing factors of anchorage performance of concrete bonded rebars
Authors: Wang Qichao , Liu Yingli , Han Ziang
Published: May 2022

Hilti re-100 structural adhesive is used to plant reinforcement in concrete, and the factors affecting the anchorage performance of planted reinforcement are analyzed. The Planting reinforcement of the concrete specimen and the specimen with reinforcement anchored in concrete in advance are compared. A total of 36 groups of tests were carried out, including 27 groups of embedded reinforcement tests and 9 groups of embedded reinforcement tests. The test mainly analyzes the influence of concrete strength, reinforcement diameter and planting depth on the anchorage performance of planting reinforcement. There are three failure modes in the test, which are the separation failure of reinforcement and structural adhesive, the tensile failure of reinforcement and the separation failure of reinforcement and concrete. Through the analysis of the test data, the bond slip data curve is obtained.
Síndrome mononucleósico con síndrome nefrítico agudo asociado en paciente pediátrica
Authors: Gallo Sáenz Claudia Marcela , Moreno Ramirez Santiago , Valencia Palacio Eduar , Uribe Castrillón Lina María , Atehortúa Baena Pahola Shirley , D'Amato Gutiérrez Mónica
Published: May 2022

La mononucleosis infecciosa es un síndrome clínico de causa viral que generalmente tiene un curso benigno y autolimitado, caracterizado por fiebre, faringoamigdalitis y adenomegalias generalizadas, siendo la afectación de órganos o sistemas algo inusual. Se presenta el caso de una niña de ocho años con un síndrome mononucleósico por virus de Epstein-Barr y Citomegalovirus, con un síndrome nefrítico agudo hipocomplementémico secundario, sin deterioro de la función renal y evolución clínica favorable. La ausencia de un período de latencia entre el proceso infeccioso y la aparición de los síntomas de síndrome nefrítico, es un elemento clave en el diagnóstico diferencial con el síndrome nefrítico agudo postestreptocócico, que es la causa más común en niños.
Análisis de las causas de la migración en el contexto del cambio climático según el Grupo Intergubernamental de Expertos sobre el Cambio Climático
Authors: García Maldonado Edgar
Published: May 2022

El cambio climático es uno de los temas que más se han estudiado durante los últimos años. Tanto las ciencias físicas como las disciplinas sociales y las humanidades se han ocupado profusamente de la naturaleza, las causas y los efectos del calentamiento global sobre todas las dimensiones de la realidad. Uno de esos temas son las migraciones. En este artículo se analizan los hallazgos que el Grupo Intergubernamental de Expertos sobre el Cambio Climático ha plasmado en sus seis informes de evaluación acerca de la relación entre el cambio climático y las migraciones, tomando como marco de referencia los desplazamientos de personas que, durante los últimos años, han abandonado sus hogares en Centroamérica para dirigirse a Estados Unidos. El objetivo es demostrar que existe un vínculo causal cambio climático-migraciones en los reportes del Grupo Intergubernamental de Expertos sobre el Cambio Climático que se fundamenta en el determinismo climático. Se parte de las nociones de ideología y de reduccionismo climático, propuestas por Mike Hulme (2011), para establecer que, con algunas diferencias de grado, al sostener que las migraciones son una respuesta de adaptación frente a los efectos del calentamiento del planeta, el Grupo Intergubernamental de Expertos sobre el Cambio Climático está reproduciendo una perspectiva de los procesos sociales que hunde sus raíces en el determinismo ambiental, tanto como aproximación metodológica de la realidad como instrumento de legitimación política del orden social.
Comunicação, patrimônio e cultura: discutindo contribuições científicas
Authors: Letícia Peret Antunes Hardt  , Carlos Hardt  , Marlos Hardt
Published: May 2022

Voltada à problemática da reduzida interlocução sobre bens patrimoniais da cultura no Brasil, esta pesquisa tem estrutura multimétodos, feição qualiquantitativa e caráter exploratório. Seu objetivo geral consiste em discutir a comunicação de manifestações do patrimônio cultural pela produção científica nacional, com seus procedimentos metodológicos atrelados a quatro recortes principais. No primeiro (temático), foram estabelecidos os assuntos centrais da investigação, enquanto no segundo (editorial) foi selecionado, como amostra, um periódico de veiculação dos objetos de estudo, representados pelos artigos publicados no período de setembro de 2012 a março de 2021, que constituiu o terceiro recorte (temporal). No último (processual), executou-se o inventário bibliométrico para revisão sistemática dos textos, envolvendo vários filtros discriminatórios. Os resultados são expressos tanto em termos quantitativos, com explicitação das métricas encontradas, quanto de modo qualitativo, pelo debate de categorias analíticas dos teores estudados, classificadas em difusões museológicas, divulgações comunicacionais, revelações sociais e expressões populares. Conclui-se, por fim, pela relevância de contribuições disponibilizadas por revistas especializadas, interpretadas como importantes meios de comunicação da ciência e especialmente da temática tratada, com benefícios diretos e indiretos à sociedade como um todo.
Saber-fazer gastronômico no Brasil
Authors: Conceição Campos Pena Lara , Pinheiro Teixeira Alice , Filgueiras Rebelo de Matos Márcia , De Cássia Vieira Cardoso Ryzia
Published: May 2022

Os produtos gastronômicos tradicionais possuem sua produção pautada em saberes e fazeres coletivos, de transmissão geracional, que estão nas bases identitárias brasileiras. Para circunstanciar as trajetórias de salvaguarda desses bens culturais imateriais, este artigo utilizou uma análise documental das legislações nacionais e de produções científicas sobre o tema nos últimos anos. As duas principais ferramentas de proteção do saber-fazer tradicional no Brasil - os livros de registro do IPHAN e as Indicações Geográficas do INPI - possuem distintas estratégias de preservação de produtos alimentares de identidades coletivas, porém, já existem articulação entre esses dois mecanismos, que podem ser potencializadas para melhor atender as necessidades das comunidades tradicionais produtoras de alimentos.
Bleaching and enamel microabrasion in the smile esthetics: a case report
Authors: Thais de Paula Faccio Alves  , Ana Flávia Simões Barbosa  , Thaís Fantinato Trindade  , Carolina de Andrade Lima Chaves  , Walter Raucci Neto  , Vivian Colucci
Published: May 2022

The color change of teeth is frequent in the dental office and has important role in smile harmony. Objective: To discuss through case report the dental bleaching technique associated with enamel microabrasion to remove localized white spots on the maxillary incisors and canines. Case report: Patient, female, aged 18 years, attended the Clinic of the University of Ribeirão Preto complaining about the negative aesthetics of her smile due to the presence of white spots on teeth #13, #12, #11, #21, #22 and #23. After detailed anamnesis and clinical examination, the spots were diagnosed as enamel demineralization caused by cariogenic challenge occurred during the use of orthodontic brackets. Dental bleaching technique with 38% hydrogen peroxide was applied followed by enamel microabrasion with 6.6% hydrochloric acid and silicon carbide paste. After absolute isolation, 1 mm thick paste was applied on enamel stain with the aid of resin composite polishing abrasive rubber. Each application was followed by copious washing and analysis of the stain removal with wet enamel surface. In total, six applications of 10 seconds each were used. Finally, enamel polishing was executed with felt discs and diamond paste, and topical application of fluoride. Conclusion: It was concluded that bleaching associated with enamel microabrasion technique is a safe, simple, and effective option for solving the esthetics of teeth with white spots.
Reestablishing aesthetic and function of patient with severe worn dentition: a conservative approach with provisional fixed tooth/implant supported prosthesis
Authors: Guilherme Gonçalves Andreatta  , Fernanda Durski Teixeira  , Leonardo Fernandes Cunha  , Adilson Yoshio Furuse  , Gisele Maria Correr Nolasco  , Carlos Eduardo E. Rezende
Published: May 2022

Patients with severe parafunctional habits can have a reduction of their occlusal vertical dimension (OVD) and may create complex cases of oral rehabilitation, in which the patient may develop occlusal, masticatory and psychological problems. Objective:To report a clinical case of restoration of masticatory function and aesthetics from the production of tooth/implant-supported prostheses with conservative preparations, reestablishing the OVD and occlusal stability. Case report: Patient MVN, 55 years old, wheelchair user, presenting bruxism with a history of gastric reflux due to hiatal hernia, attended the clinic at the University complaining of dental sensitivity, difficulty in chewing and aesthetic smile commitment.At clinical examination it was found widespread wear of teeth. Radiographic examination showed good periodontal health and dental implants in good condition of osseointegration. The OVD was established from the VDR and confirmed by the metric method. The initial casts were positioned on the articulator for diagnostic waxing. From the waxing it was possible to make provisional fixed tooth/implant-supported prostheses. In the lower arch, the prosthesis was screwed on the implants #35, #37, #46, and #47, with the remaining teeth working as an auxiliary support, while in the upper arch two interim prosthesis were made, one for the elements #16 and #17 (tooth-supported) and one for the elements #13, #12, #11, #21, #22, #23, #24 (tooth/implant-supported). Thus, the OVD and the aesthetics lost by bruxism abrasion were restored. Conclusion:This case demonstrates the importance of the provisional prostheses for aesthetic and functional rehabilitation of patients with severe worn dentition.
Endodontic retreatment of dens invaginatus: clinical and radiographic report
Authors: Bruno Crozeta  , Allan Abuabara  , Bruno Marques-da-Silva  , Jessica Vavassori  , Flares Baratto-Filho  , Denise P. Leonardi
Published: May 2022

Dens invaginatus, a developmental malformation resulting from the invagination of enamel, has been associated with increased prevalence of pulpal and periapical diseases. Case report: This anomaly is classified according to the severity (types I-III). Management of type III dens invaginatus is complex and an endodontic challenge. This case report describes the management of the endodontic retreatment type III dens invaginatus in a maxillary lateral incisor. Conclusion: Nonsurgical treatment can be effective to treat type III dens invaginatus. CBCT is an important diagnostic tool that allowed the management of such case.
Relationship of salivary flow of diabetic patients
Authors: Laís Santos Peres  , Dayani Galato  , Gláucia Helena Faraco de Medeiros1
Published: May 2022

Diabetes mellitus is a highly prevalent health condition. Its systemic changes cause oral manifestations that may or may not be associated. Objective: To investigate the presence of xerostomia in patients with diabetes. Materials and methods: This study consisted of a series of cases with 22 diabetic patients of the Family Health Strategy (FHS), neighborhood of Dehon, city of Tubarão (SC). A socio-demographic questionnaire was applied, the perception of dry mouth assessed, and the salivary flow measured at rest and after stimulation. To evaluate the association was adopted p<0.05. Results: 77% of patients had dry mouth feeling symptoms compatible with a diagnosis of xerostomia; of these, only 65% had stimulated salivary flow below the reference values (≤0.7ml/min) compatible with hyposalivation also demonstrating the association between xerostomia and hyposalivation. No statistically significant differences occurred between patients using xerostomic medication and decreased salivary flow when stimulated (p=0.15) and dry mouth sensation (p=0.30). Conclusion: The observed diabetic patients have a high prevalence of xerostomia, however, without association with any drug.
Stem cells carrier scaffolds for tissue engineering
Authors: Thaysa Fedalto Lopes  , Agnes Levandowski  , Sabrina Cunha da Fonseca  , João Cesar Zielak  , Moira Pedroso Leão
Published: May 2022

Mesenchymal Stem Cells (MSCs) can be isolated from several body tissues, including dental tissues. As a result of being capable of differentiating into a variety of cell types, it can be presumed that stem cell therapy has an advantage compared to other tissue repair methods. Objective: The aim of this paper is to provide a review about current and future materials for scaffolds to carry stem cells in tissue engineering in Dentistry, especially for bone tissue repair. Literature review: MSCs have great therapeutic potential in tissue engineering, they can be expanded in vitro, and combined with scaffolds to be inserted into defects to promote healing and tissue replacement. Conclusion: Stem cells from dental tissues have a real potential in Advanced Therapies. The combination of inductive scaffold materials with stem cells might optimize the approaches for bone regeneration. Although there are numerous available biomaterials potentially compatible to combine with MSCs, more studies need to be performed, due to the fact that for each indication there will be a more suitable material according to the defect’s biological and mechanical requirement.
Digital planning for smile reconstruction with ceramic laminates: case report
Authors: Giulian Lennon de Macêdo  , Cristóvão José de Lima Silva Filho  , Iris Durães  , Carmen de Andrade Vilas Boas
Published: May 2022

The ceramic laminates gained space in Esthetic Dentistry due to conservative preparations, excellent optical properties, durability, and longevity. Additionally, the use of digital planning to assist the smile reconstruction also allows the outcome predictability. Objective: To present and discuss a clinical case of smile reconstruction with ceramic laminates using as esthetic planning the Digital Smile Design. Case report: A 25-year-old female reported dissatisfaction with her smile. After clinical and radiographic exam, Digital Smile Design was the method chosen, which enabled to verify the need for clinical crown augmentation and to construct the porcelain laminates for the maxillary anterior teeth. After the mock-up and the patient’s agreement, the treatment was performed. Results: A significant improvement in the esthetics of the planned smile, with approval of the patient was obtained. Conclusion: The digital planning for smile reconstruction with ceramic laminates proved to be an excellent tool to aid in this choice of treatment.
Esthetic rehabilitation of anterior teeth through gingival recontouring and ceramic veneers: a case report
Authors: Orides Ferrari Jr.  , Fernando Dalitz  , Marina Samara Baechtold  , Ubiracy Gaião  , Leonardo Fernandes da Cunha  , Carla Castiglia Gonzaga  , Gisele Maria Correr
Published: May 2022

Esthetic rehabilitations require a broad and thorough evaluation of all the elements that make up the smile such as lips, dental, and periodontal structures to plan the treatment to provide harmony to the whole set. Objective: To demonstrate through a case the association of Periodontics and Restorative Dentistry in the esthetic rehabilitation of anterior teeth replacing resin restorations by modifying the gingival architecture conservatively and harmonically. Case report: It is essential for a multidisciplinary approach to succeed in treatment. The replacement of previous restorations is an increasing demand in currently clinical practice, for many reasons, mainly due to dissatisfaction with the esthetics. It is observed that many of these patients involve not only dissatisfaction with the dental structure but also with the periodontal health, for this reason, it is necessary a previous adaptation of the gingival tissues for proper restorative rehabilitation. Conclusion: Ceramic laminates have proved to be a great choice for anterior teeth restorations, but they must be indicated in specific situations, to obtain excellent results as most conservative as possible.
Link of BIN1, CLU, and fIDE Gene Polymorphisms with the Susceptibility
of Alzheimer’s Disease: Evidence from a Meta-analysis
Authors: Abdul Aziz Md. , Md Ashraf Ghulam , Safiqul Islam Mohammad
Published: May 2022

Background:

Alzheimer’s disease (AD) is the most common form of neurodegenerative disorder.
The association of BIN1, CLU, and IDE genetic polymorphisms with AD risk have been evaluated
overtimes that produced conflicting outcomes.

Objective:

We performed this meta-analysis to investigate the contribution of BIN1 (rs744373 and
rs7561528), CLU (rs11136000 and rs9331888), and IDE (rs1887922) polymorphisms to AD risk.

Methods:

From a systemic literature search up to July 15, 2021, we included 25 studies with rs744373,
16 studies with rs7561528, 37 studies with rs11136000, 16 studies with rs9331888, and 4 studies with
rs1887922. To analyze the correlation, we constructed seven genetic models that used odds ratio and
95% confidence intervals. We used RevMan 5.4 for meta-analysis.

Results:

Our study suggests that BIN1 rs744373 is associated with a significantly increased risk of AD
in five genetic models (OR>1). Again, CLU rs11136000 showed reduced association in all genetic
models (OR<1). CLU rs9331888 revealed an increased association in two models (OR>1). The IDE
rs1887922 showed significantly increased risk in four models (OR>1). From subgroup analysis, a significantly
increased risk of AD was observed in Caucasians and Asians for BIN1 rs744373. Again,
BIN1 rs7561528 showed a significantly enhanced risk of AD only in Caucasians. CLU rs11136000
showed significantly reduced risk in Caucasians but rs9331888 showed increased risk in the same ethnicity.

Conclusion:

Our meta-analysis confirms the association of BIN1 rs744373, CLU rs9331888, and IDE
rs1887922 polymorphisms with an increased risk of AD, especially in Caucasians. Again, CLU
rs11136000 is associated with reduced AD risk in the overall population and Caucasians.
Therapeutic Potential of Naturally Occurring Lignans as Anticancer Agents
Authors: Shi Yumin , Wang Jun , Yan Heng
Published: May 2022

:

Cancer is a long-term and deadly pandemic that affects nearly a third of the world's population. Chemotherapy is currently the most common therapeutic treatment, but it is difficult to achieve satisfactory efficacy due to drug resistance and adverse effects.Natural products are becom-ing increasingly popular in cancer therapy due to their potent broad-spectrum anticancer potency and slight side effects. Lignans are complex diphenolic compounds comprising a family of second-ary metabolites existing widely in plants. Naturally occurring lignans have the potential to act on cancer cells by a range of mechanisms of action and could inhibit the colony formation, arrest the cell cycle in different phases, induce apoptosis, and suppress migration, providing privileged scaf-folds for the discovery of novel anticancer agents. In recent five years, a variety of naturally occur-ring lignans have been isolated and screened for their in vitro and/or in vivo anticancer efficacy, and some of them exhibited promising potential. This review has systematically summarized the re-sources, anticancer activity, and mechanisms of action of naturally occurring lignans, covering arti-cles published between January 2017 and January 2022.
WITHDRAWN: Anzi Mixture Reduces ACA Levels and Decreases the Embryo Absorption Rate of ACA Positive Abortion Mice via Modulating
T-bet/GATA-3 Molecules and Th1/Th2 Cell-associated Cytokines
Authors: Guo Hongyu , Ren Qingling , Chen Cong , Qian Jing , Zhao Yuqing , Lu Qibin
Published: May 2022

Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, therefore, the article has been
withdrawn from the journal Letters in Drug Design & Discovery.

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php.

BENTHAM SCIENCE DISCLAIMER:

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must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting
the article for publication the authors agree that the publishers have the legal right to take appropriate action against the
authors, if plagiarism or fabricated information is discovered. By submitting a manuscript the authors agree that the copyright
of their article is transferred to the publishers if and when the article is accepted for publication.
Hospital Incidence and Medical Costs of Female Breast Cancer in Spain: A
Retrospective Multicenter Study
Authors: Darbà Josep , Marsà Alicia
Published: May 2022

Background:

Breast cancer is the most prevalent cancer in women worldwide, causing the
greatest number of cancer-related deaths. This study aimed to evaluate the use of healthcare resources associated with female breast cancer in Spain, to analyze trends in hospitalization and death
rates, and the related direct medical costs

Methods:

A retrospective multicenter study analyzed records of hospital and ambulatory visits of
women diagnosed with breast cancer in Spanish hospitals between 1st January 2005 and 31st December 2018.

Results:

In total, 353,080 admission files were reviewed, mainly inpatient hospital admissions, corresponding to 299,585 individual patients. The median patient age was 59 years, 12.7% of admissions registered the presence of metastatic tumors, and 15.7% registered unspecified secondary tumors. The mean in-hospital death rate was 3.0% for patients without a metastatic disease and 10.5%
for patients with metastatic disease, decreasing significantly over the study period. The total age adjusted hospitalization rate increased between 2005 and 2011 and decreased after 2012. The mean
direct medical cost was €3824 per outpatient visit, €3995 per hospital admission up to 3 days and
€5001 per hospital admission over 3 days. Admission costs increased in patients with metastatic
disease and those deceased during hospitalization

Conclusion:

This study supports previous findings regarding the relative increase in breast cancer
incidence that could be attributed to the intensive screening and the reduction in the death rate. Mean
direct medical cost in this study varied greatly with the length of stay, presence of metastatic tumors
and disease fatality.
Mesenchymal Stem Cells: New Alternatives for Nervous System Disorders
Authors: Jiménez-Acosta Miguel Antonio , Hernández Lory Jhenifer Rochin , Cristerna Mayte Lizeth Padilla , Meraz-Ríos Marco Alejandro
Published: May 2022

:

Mesenchymal stem cells (MSCs) are self-renewing cells found in almost all postnatal organs and tissues in the perivascular region. These cells have a high capacity for mesodermal differentiation; however, numerous studies have shown that MSCs can also differentiate into cells of endodermal and ectodermal lineages. Due to this multilineage differentiation capacity, these cells could function as restoratives of various cell populations after transplantation. However, not only their differentiation potential makes them ideal candidates for this, but also a series of trophic properties that promote regeneration in the surrounding tissue, such as their migratory capacity, secretory and immunomodulatory actions. This review analyzes several MSC transplantation trials to treat neurological diseases such as demyelinating injury, spinal cord injury, paraplegia, Parkinson's disease, cochlear injury, and Alzheimer's disease. These cells could facilitate functional recovery in multiple models of neurodegenerative diseases and nervous system injuries by using their trophic capacities, reducing inflammation in the injured area, reducing apoptosis, and enhancing endogenous neurogenesis through the secretion of bioactive factors. Furthermore, since cells derived from patients have demonstrated disease-associated differences in various brain diseases, these cells represent an excellent candidate for the study of these diseases, functioning as "a window to the brain."
Screening and in Silico Functional Analysis of MiRNAs Associated with
Acute Myeloid Leukemia Relapse
Authors: Fard Ali Amini , Rahimi Hamzeh , Shams Zinat , Ghoraeian Pegah
Published: May 2022

Background:

Hematologic malignancies are among fatal diseases with different subtypes. Acute myeloid leukemia (AML) is a subtype that shows a high rate of invasion to different tissues.

Objective:

AML patients even after treatment show an increased rate of recurrence and this relapsed profile of AML has turned this malignancy into big challenges in the medical scope.

Methods:

In the current study, we aimed to investigate hub-genes and potential signaling pathways in AML recurrence. Two expression profiles of genes and non-coding RNAs were extracted from Gene Expression Omnibus (GEO) database. Target genes of identified miRNAs were predicted through bioinformatics tools. GO and KEGG pathway enrichment analyses were conducted to discover common target genes and differentially expressed genes. Protein‐protein interaction (PPI) network constructed and visualized through STRING online database and Cytoscape software respectively. Hub-genes of constructed PPI were found through the CytoHubba plugin of Cytoscape software.

Results:

As a result, 109 differentially expressed genes and 45 differentially expressed miRNAs were found, and the top enriched pathways were Immune response, Chemokine activity, Immune System, and Plasma membrane. The hub-genes were TNF, IL6, TLR4, VEGFA, PTPRC, TLR7, TLR1, CD44, CASP1, and CD68.

Conclusion:

The present investigation based on the in silico analysis and microarray GEO databases may provide a novel understanding regarding the mechanisms related to AML relapse.
Keywords: Acute myeloid leukemia, AML, Bioinformatics, microRNA, Protein‐protein interaction, Cancer.
An Overview of Cistus Species Growing in Sardinia: A Source of Bioactive Compounds
Authors: Mastino Patrizia M. , Mauro Marchetti , Juliano Claudia , Usai Marianna
Published: May 2022

Extracts obtained from many plants have recently gained popularity and
scientific interest for their antibacterial, antifungal and antioxidant activity. Many
results have been reported on the antimicrobial properties of plant extracts containing
essential oils and different classes of phenolic compounds. In this chapter, we will
discuss the traditional usage and the biological and pharmacological properties of
various Cistus species, with particular emphasis on Cistus species growing in Sardinia.
Cistaceae family is widespread in the Mediterranean region with several species, and it
is known as a traditional natural remedy. Cistus genus grows in Sardinia with
populations of C.monspeliensis, C.salvifolius, C. albidus and C. creticus subspecies:
C.creticus subsp. creticus, C.creticus subsp. corsicus, and C.creticus subsp.
eriocephalus. Despite being widespread, only a few phytochemical research has been
reported for Cistus species growing in Sardinia. Moreover, C.creticus subsp.
eriocephalus (Viv) Greuter & Burdet growing in Sardinia is characterized by an
important polymorphism due to hybridization and occurrence of various ecotypes
based on intermediate morphological characters. The recent studies have shown that
the extracts of Cistus species may be used as therapeutic agents in a wide range of
human diseases. The use of plant extracts for controlling postharvest fungal pathogens
can enhance healthy fruit production. Further knowledge regarding the bioactivity of
Sardinian Cistus species will be useful to verify their potential as profitable sources of
functional ingredients in applications, such as food preservation, cosmetic, hygiene or
medical device.
Plant Metabolites may Protect Human Cells against Radiation-associated Damage: An Integrative Review
Authors: Victório Cristiane Pimentel , Peixoto Fernanda Marques , de Souza Edmilson Monteiro , de Salles João Bosco , Cardoso Alexander Machado , Assis Maria Cristina de
Published: May 2022

The human body is exposed to natural sources of ionizing radiation including cosmic rays, radionuclides disposed on the Earth's crust, air, water, and food. In addition, man-made radiation sources for military and civil purposes such as the use of radiation in health care, medical procedures in the diagnosis and treatment of diseases, scientific researches, and energy production can contribute to the increased exposure and may affect the human cells. Many derivatives of plant extracts or genetically modified plants have been employed as radiomodifiers as they are compounds that can modify the biological response to the damage induced by the radiation. On the other hand, radiomodulators can be used for varied medical applications such as radioprotection and radiosensitization of tumor cells. This chapter aims to identify, analyze, and synthesize results of independent studies through an integrative review, which evaluated the protective effects of plant metabolites on cell injury caused by radiation therapy against cancer and high doses of radiation exposure.
De dialectiek van interventie en contra-interventie: een eigentijdse geschiedenis
Authors: ten Cate Arthur
Published: May 2022

Deze oratie bespreekt competities van georganiseerd geweld, van interventie en contra-interventie, in conflictgebieden en postconflictgebieden. De dynamiek van opeenvolgende acties en reacties van interventietroepen en hun tegenstanders in moderne conflictsituaties wordt daarbij voorgesteld als een dialectische ontwikkeling, in de betekenis van een reëel historisch proces dat wordt gekenmerkt door de zich (steeds) herhalende, tegengestelde belangen, opvattingen en handelingen van die actoren. Een wetenschappelijke dialectiek van interventie en contra-interventie is – in de bedoeling van deze oratie – een beschrijving en indruk van een empirisch waar te nemen, autonome historische realiteit. Interventies, hun tegenreacties én de onderlinge dynamiek in deze competities, manifesteren zich het meest duidelijk in het contemporaine tijdvak. Het dialectisch opvatten van dit fenomeen betreft een analytisch gebruik ter wille van het vergroten van onze kennis over internationale crisisbeheersing en internationale militaire missies en vredesoperaties.