bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparing the effects of injecting bupivacaine, tramadol, and bupivacaine-tramadol combination at the surgical incision site on pain intensity and postoperative complications in patients undergoing elective cesarean section: A randomized controlled trial
Authors: Emadi Seyed Abdollah , ghadirian Hamid , kargar-soleimanabad Saeed , Ghadirzadeh Erfan , Nikzad-Jamnani Alireza
Published: November 2023

Abstract

Background

cesarean sections (C-sections) are the most popular surgical procedure for women of reproductive age. In the majority of procedures, effective postoperative pain management is crucial for postoperative care in order to lower morbidity and mortality while also making patients feel comfortable. The current study aims to compare the effects of injecting bupivacaine, tramadol, and bupivacaine-tramadol combination at the surgical incision site in patients undergoing elective cesarean section.

Method

The current study is a double-blind randomized clinical trial that included patients September of pregnant women referred to Obstetrics and Gynecology Clinic between 2021 June and 2022 September.

Results

This study included 180 patients (60 in each group). The average age of the patients was 31.33 years, and the difference in vas 6, vas 12, and vas 24 scores between groups was significant (P > 0.001). The group that used drugs in combination experienced significantly less pain and there was no significant difference in analgesic drug consumption.

Discussion and conclusion

results of the current study revealed there was a significant difference in vas 6, vas 12, and vas 24 scores between the groups, with the group of bupivacaine-tramadol combination providing a greater analgesic effect. However, there is no statistically significant difference in the frequency of post-operative side effects.

Highlights
Genevra Sforza and the Bentivoglio
Authors: Bernhardt Elizabeth
Published: November 2023

Genevra Sforza (c. 1441-1507) lived her long life near the apex of Italian Renaissance society as wife of two successive de facto rulers of Bologna: Sante then Giovanni II Bentivoglio. Placed twice there without a dowry by Duke Francesco Sforza as part of a larger Milanese plan, Genevra served her family by fulfilling the gendered role demanded of her by society, most notably by contributing eighteen children, accepting many illegitimates born to Giovanni II, and helping arrange their future alliances for the success of the family at large. Based on contemporary archival research conducted across Italy, this biography presents Genevra as the object of academic study for the first time. The book explores how Genevra's life-story, filled with a multitude of successes appropriate for an elite fifteenth-century female, was transformed into a concordant body of misogynistic legends about how she destroyed the Bentivoglio and the city of Bologna.
When he smiles: Attractiveness preferences for male faces expressing emotions
Authors: Carrito Mariana L. , Bismarck Francisca , Bem-Haja Pedro , Perrett David I. , Santos Isabel M.
Published: November 2023

The impact of sexual dimorphism on facial attractiveness has been controversial owing to contradictory results, particularly in studies on female preferences. Given that sexually dimorphic facial features, especially more masculine ones, have been previously related to the perception of anger, we investigated the bi-directional influence of emotional expressions and facial masculinity and explored their impact on women's preferences for facial masculinity. We confirmed the effect of facial sexual dimorphism on the perception of emotional cues (happiness and anger) and explored whether smiling or angry expressions influence women's perception of masculinity in male faces. Additionally, we examined women's preferences for emotionally expressive male faces altered along a continuum of masculinity. The results showed that masculinised faces are perceived as angrier, while feminised faces are perceived as happier (Experiment 1), and that angry faces are perceived as more masculine when compared with happy faces (Experiment 2). It is noteworthy that our Experiment 3 uncovered a pivotal finding: women prefer reduced feminisation in happy faces compared with neutral/angry faces. This suggests that the avoidance response observed towards masculinity is attenuated by a smiling expression. The current study introduces a new perspective to be considered when exploring the role of facial masculinity in women's attractiveness preferences.
A rational analysis and computational modeling perspective on IAM and déjà vu
Authors: Li Justin , Jones Steven , Laird John
Published: November 2023

The proposed memory architecture by Barzykowski and Moulin is compelling, and could be improved by incorporating a rational analysis of the functional roles of involuntary autobiographical memory and déjà vu. Additionally, modeling these phenomena computationally would remove ambiguities from the proposal. We provide examples of past work that illustrate how the phenomena may be described more precisely.
A spontaneous neural replay account for involuntary autobiographical memories and déjà vu experiences
Authors: Varma Mohith M. , Yu Rongjun
Published: November 2023

Barzykowski and Moulin argue both involuntary autobiographical memories and déjà vu experiences rely on the same involuntary memory retrieval processes but their underlying neurological basis remains unclear. We propose spontaneous neural replay in the default mode network (DMN) and hippocampus as the basis for involuntary autobiographical memories, whereas for déjà vu experiences such transient activation is limited to the DMN.
Accommodating the continuum hypothesis with the déjà vu/déjà vécu distinction
Authors: Perrin Denis
Published: November 2023

On Barzykowski and Moulin's continuum hypothesis, déjà vu and involuntary autobiographical memories (IAMs) share their underpinning neurocognitive processes. A discontinuity issue for them is that familiarity and episodic recollection exhibit different neurocognitive signatures. This issue can be overcome, I say, provided the authors are ready to distinguish a déjà vécu/episodic IAM continuity and a déjà vu/semantic IAM continuity.
The relation of subjective experience to cognitive processing
Authors: Schwartz Bennett L. , Pournaghdali Ali
Published: November 2023

Barzykowski and Moulin argue that common memory processes form the basis of involuntary autobiographical memory and the déjà vu experience. We think that they underemphasize the potential dissociability between processes that enact retrieval and the processes that produce conscious experience. We propose that retrieval and conscious experience result from different processes in both involuntary autobiographical memory and déjà vu experiences.
Spanning trees in graphs without large bipartite holes
Authors: Han Jie , Hu Jie , Ping Lidan , Wang Guanghui , Wang Yi , Yang Donglei
Published: November 2023

We show that for any
$\varepsilon \gt 0$
and
$\Delta \in \mathbb{N}$
, there exists
$\alpha \gt 0$
such that for sufficiently large
$n$
, every
$n$
-vertex graph
$G$
satisfying that
$\delta (G)\geq \varepsilon n$
and
$e(X, Y)\gt 0$
for every pair of disjoint vertex sets
$X, Y\subseteq V(G)$
of size
$\alpha n$
contains all spanning trees with maximum degree at most
$\Delta$
. This strengthens a result of Böttcher, Han, Kohayakawa, Montgomery, Parczyk, and Person.
ISOMETRIES AND HERMITIAN OPERATORS ON SPACES OF VECTOR-VALUED LIPSCHITZ MAPS
Authors: Oi Shiho
Published: November 2023

We study hermitian operators and isometries on spaces of vector-valued Lipschitz maps with the sum norm. There are two main theorems in this paper. Firstly, we prove that every hermitian operator on
$\operatorname {Lip}(X,E)$
, where E is a complex Banach space, is a generalized composition operator. Secondly, we give a complete description of unital surjective complex linear isometries on
$\operatorname {Lip}(X,\mathcal {A})$
, where
$\mathcal {A}$
is a unital factor
$C^{*}$
-algebra. These results improve previous results stated by the author.
EG-VEGF maternal levels predict spontaneous preterm birth in the second and third trimesters in pregnant women with risk factors for placenta-mediated complications
Authors: Raia-Barjat Tiphaine , Chauleur Céline , Collet Constance , Rancon Florence , Hoffmann Pascale , Desseux Morgane , Lemaitre Nicolas , Benharouga Mohamed , Giraud Antoine , Alfaidy Nadia
Published: November 2023

Prediction of spontaneous preterm birth in asymptomatic women remains a great challenge for the public health system. The aim of the study was to determine the informational value of EG-VEGF circulating levels for prediction of spontaneous preterm birth in the second and third trimesters in pregnant women at high risk for placenta-mediated complications. A prospective multicenter cohort study including 200 pregnant patients with five-serum sampling per patient. Women with spontaneous preterm birth have higher concentrations of serum EG-VEGF than uncomplicated patients at 24 weeks, 28 weeks and 32 weeks (p = 0.03, 0.02 and < 0.001). The areas under the curve reached 0.9 with 100% sensitivity at 32 weeks for the prediction of spontaneous preterm birth. Serum EG-VEGF concentrations could be considered as a reliable biomarker of spontaneous preterm birth in high-risk for placenta-mediated complications pregnant women.
Time-lapse observation of mouse preimplantation embryos using a simple closed glass capillary method
Authors: Kikuchi Yasuyuki , Ito Daiyu , Wakayama Sayaka , Ooga Masatoshi , Wakayama Teruhiko
Published: November 2023

Time-lapse observation is a popular method for analyzing mammalian preimplantation embryos, but it often requires expensive equipment and skilled techniques. We previously developed a simply and costly embryo-culture system in a sealed tube that does not require a CO2 incubator. In the present study, we developed a new time-lapse observation system using our previous culture method and a glass capillary. Zygotes were placed in a glass capillary and sunk in oil for observation under a stereomicroscope. Warming the capillary using a thermoplate enabled most of the zygotes to develop into blastocysts and produce healthy offspring. This time-lapse observation system captured images every 30 min for up to 5 days, which confirmed that the developmental speed and quality of the embryos were not affected, even with fluorescence. Overall, this new system is a simple time-lapse observation method for preimplantation embryos that does not require dedicated machines and advanced techniques.
Characterization of NFE2L1-616, an isoform of nuclear factor-erythroid-2 related transcription factor-1 that activates antioxidant response element-regulated genes
Authors: Ho Daniel V. , Suryajaya Kaylen G. , Manh Kaitlyn , Duong Amanda N. , Chan Jefferson Y.
Published: November 2023

The NFE2L1 transcription factor (aka Nrf1) is a basic leucine zipper protein that performs a critical role in the cellular stress response pathway. Here, we characterized a novel variant of NFE2L1 referred to as NFE2L1-616. The transcript encoding NFE2L1-616 is derived from an intronic promoter, and it has a distinct first exon than other reported full-length NFE2L1 isoforms. The NFE2L1-616 protein constitutively localizes in the nucleus as it lacks the N-terminal amino acid residues that targets other full-length NFE2L1 isoforms to the endoplasmic reticulum. The expression level of NFE2L1-616 is lower than other NFE2L1 isoforms. It is widely expressed across different cell lines and tissues that were examined. NFE2L1-616 showed strong transcriptional activity driving luciferase reporter expression from a promoter containing antioxidant response element. Together, the results suggest that NFE2L1-616 variant can function as a positive regulator in the transcriptional regulation of NFE2L1 responsive genes.
Prevalence, awareness, and patterns of non-steroidal anti-inflammatory drug use among health science students in Palestine: a cross-sectional study
Authors: Aboalrob Aseel I. , Eid Falasteen M. , Esa Saba M. , Koni Amer A. , Al-Jabi Samah W. , Zyoud Sa’ed H.
Published: November 2023

Despite the widespread use of nonsteroidal anti-inflammatory drugs (NSAIDs), many people lack sufficient awareness regarding their side effects and proper usage. Consequently, this study aimed to assess the knowledge, behavior, and usage patterns of NSAIDs among students enrolled in Palestinian health colleges. The study was conducted in December 2020 using a cross-sectional design, and a convenience sampling method was employed to enroll a total of 206 students. The questionnaire comprised seven sections, each containing approximately 5 to 10 closed-ended questions. Data were analyzed using version 21 of the Statistical Package for the Social Sciences (IBM-SPSS Statistics 21). The percentage of respondents who admitted that NSAIDs were used several times in the year was 35.9%. More than half of the students believed that NSAIDs were generally safe. Seventy-two percent of the students were aware that more than one type of NSAID at the same time increased the side effects. The median knowledge score of NSAID side effects was 9 [6.25–11] out of 13. The knowledge score increased significantly with age (p < 0.001), higher academic year (p < 0.001), and pharmacy and medicine specialties (p = 0.002). The college students surveyed in this study possess a general awareness of NSAIDs. Nonetheless, there remains a necessity to enhance their behavior and practices concerning the utilization of NSAIDs through the implementation of programmed educational strategies.
Extreme diversity of 12 cations in folding ALS-linked hSOD1 unveils novel hSOD1-dependent mechanisms for Fe2+/Cu2+-induced cytotoxicity
Authors: Lim Liangzhong , Kang Jian , Song Jianxing
Published: November 2023

153-Residue copper-zinc superoxide dismutase 1 (hSOD1) is the first gene whose mutation was linked to FALS. To date, > 180 ALS-causing mutations have been identified within hSOD1, yet the underlying mechanism still remains mysterious. Mature hSOD1 is exceptionally stable constrained by a disulfide bridge to adopt a Greek-key β-barrel fold that accommodates copper/zinc cofactors. Conversely, nascent hSOD1 is unfolded and susceptible to aggregation and amyloid formation, requiring Zn2+ to initiate folding to a coexistence of folded and unfolded states. Recent studies demonstrate mutations that disrupt Zn2+-binding correlate with their ability to form toxic aggregates. Therefore, to decode the role of cations in hSOD1 folding provides not only mechanistic insights, but may bear therapeutic implications for hSOD1-linked ALS. Here by NMR, we visualized the effect of 12 cations: 8 essential for humans (Na+, K+, Ca2+, Zn2+, Mg2+, Mn2+, Cu2+, Fe2+), 3 mimicking zinc (Ni2+, Cd2+, Co2+), and environmentally abundant Al3+. Surprisingly, most cations, including Zn2+-mimics, showed negligible binding or induction for folding of nascent hSOD1. Cu2+ exhibited extensive binding to the unfolded state but led to severe aggregation. Unexpectedly, for the first time Fe2+ was deciphered to have Zn2+-like folding-inducing capacity. Zn2+ was unable to induce folding of H80S/D83S-hSOD1, while Fe2+ could. In contrast, Zn2+ could trigger folding of G93A-hSOD1, but Fe2+ failed. Notably, pre-existing Fe2+ disrupted the Zn2+-induced folding of G93A-hSOD1. Comparing with the ATP-induced folded state, our findings delineate that hSOD1 maturation requires: (1) intrinsic folding capacity encoded by the sequence; (2) specific Zn2+-coordination; (3) disulfide formation and Cu-load catalyzed by hCCS. This study unveils a previously-unknown interplay of cations in governing the initial folding of hSOD1, emphasizing the pivotal role of Zn2+ in hSOD1-related ALS and implying new hSOD1-dependent mechanisms for Cu2+/Fe2+-induced cytotoxicity, likely relevant to aging and other diseases.
Coexistence of topological node surface and Dirac fermions in phonon-mediated superconductor YB2C2
Authors: Wang Siqi , Zhong Mingmin , Liu Haibo , Ju Meng
Published: November 2023

Based on first-principles calculations, the calculated electronic band structures of superconductor YB2C2 reveal that a zero-dimension Dirac point and two-dimensional nodal surface coexist near the Fermi level.
Cluster size dependent coordination of formate to free manganese oxide clusters
Authors: Lang Sandra M. , Bernhardt Thorsten M. , Bakker Joost M. , Barnett Robert N. , Landman Uzi
Published: November 2023

Manganese oxide clusters deprotonate the hydroxyl group of formic acid yielding a strongly cluster size dependent binding motif of the formate group.
Theoretical study on porphyrin arch-tapes of carbonyl-inserted seven-membered rings with high nonlinear optical properties
Authors: Ye Jin-Ting , Wang Li-Hui , Yu Jia-Qi
Published: November 2023

Carbonyl-inserted arch-tapes displayed distinctly nonlinear optical properties owing to an active involvement of the carbonyl group(s) in electronic conjugation.
Correlation of solute diffusion with dynamic viscosity in lithium salt-added (choline chloride + glycerol) deep eutectic solvents
Authors: Kumar Manish , Pandey Siddharth
Published: November 2023

Effect of dynamic viscosity on the solute diffusion within lithium salt-added (choline chloride + glycerol) deep eutectic solvent.
Electronic excited states of monobromosilylene molecules including the spin–orbit-coupling
Authors: Bian Lili , Shan Shimin , Lian Yi , Xiao Lidan , Liu Di , Lv Hang , Xu Haifeng , Yan Bing
Published: November 2023

The electronic excited states of monobromosilylene molecules, along with spin–orbit-coupling and photodissociation dynamics, have been investigated.
Estimating impacts of LCRR's fifth-liter sampling and find-and-fix requirements on large water systems
Authors: Bradley Tyler C. , Masters Sheldon V. , Bartrand Timothy A. , Sales Christopher M.
Published: November 2023

This study demonstrates a data driven method for estimating fifth-liter water lead levels from first-liter water lead data.
Reaction analysis and the removal mechanism of organic contaminants in plasma cleaning: a molecular dynamics simulation
Authors: Bai Qingshun , Liu Xujie , Sun Hao , Li Yuhai , Xu Xueshi , Zhang Peng
Published: November 2023

DBP clusters were removed by nitrogen and oxygen plasma. The effects of the incidence duration, particle energies, and particle types on the decomposition were investigated. Decomposition pathways were further confirmed by bond dissociation energies.
Iridium/nickel dual catalyzed hydroacylation of hetero-bicyclic alkenes under visible-light irradiation
Authors: Meng Li , Yang Chunhui , Dong Jun , Wen Wanliu , Chen Jingchao , Fan Baomin
Published: November 2023

Hetero-bicyclic alkenes are versatile synthetic motifs for the synthesis of highly substituted ring systems.
Rapid modular synthesis of indole ethers via dehydrogenative cross-coupling reaction of indoles and alcohols
Authors: Huang Mao-Gui , Chen Xiao-Hong , Xu Hai-Bing , Liu Yue-Jin
Published: November 2023

Indole ethers are commonly found in pharmaceuticals, enzymes, and many bioactive compounds.
Recent advances in photochemical and electrochemical strategies for the synthesis of sulfonyl fluorides
Authors: Zheng Yu , Lu Wenguang , Ma Tianting , Huang Shenlin
Published: November 2023

This review summarizes the latest achievements in photochemical and electrochemical strategies for the synthesis of sulfonyl fluorides and focuses on the novel features and proposed mechanisms.
Impact of carbon quantum dots on self-assembly and dielectric relaxation modes of a room temperature tri-component fluorinated antiferroelectric liquid crystal mixture
Authors: Iqbal Amir , Urbanska Magdalena , Dąbrowski Roman S. , Kumar Sandeep , Dhar Ravindra
Published: November 2023

We investigated the impact of carbon quantum dots (CQDs) of sizes ∼2–5 nm in a room temperature tri-component fluorinated antiferroelectric liquid crystal (AFLC) mixture.
A feasibility analysis of image approximation with image quality assessments
Authors: Rahman Md. Abdur , Huq Aminul , Tunny Salma Sultana , Anik Maruf Hossain , Pervin Mst Tasnim , Islam Md. Rashidul
Published: November 2023

With technological developments, the resolution of the display systems is increasing, causing image data to increase. Several technologies are aiding in optimizing these data during transmission and storage while maintaining quality. Still, the internal data transmission for accessing the memory sub‐system during reading and writing cycles consumes significant power while requiring large memory for storage, which is inefficient, especially for portable displays. Hence, this work investigates the feasibility of reducing data through approximation for images in different formats and resolutions for human and computer vision based applications. Different image quality assessment metrics are utilized for performance evaluations with optimum image quality assessment selection according to application requirements. In addition, the feasibility analysis is conducted for three different applications as examples of computer vision. The experimental analysis highlights theoretical and industrial importance by showing that image data can be reduced from 25.0% to 62.5%, while satisfying requirements for HVS‐based and computer vision‐based applications.
Time domain response of corrugated transmission lines
Authors: Wu Chia Ho , Wang Wei , Peng Song Tsuen , Qian Zhenyu , Shen Jianqi , Ye Guoqiang , Ni Donghua , He Fang , Shen Linfang , Quan Bisheng , Jiao Yajie
Published: November 2023

In order to employ periodic corrugated microstrip lines for reducing or suppressing electromagnetic interference in high‐speed or high‐frequency circuits, a precise method is necessary to calculate and measure the characteristic impedance of periodic microstrip lines. The equation for characteristic impedance (depending on frequency) of lossless periodic microstrip lines was obtained based on the transfer matrix method. A time domain pulse was used to measure the instantaneous impedance of conventional microstrip lines, and when the instantaneous impedance does not change with distance, it can be identified as the characteristic impedance of microstrip lines. However, when the time‐domain pulses are employed to measure the instantaneous impedance of periodic microstrip lines, rapid oscillations occur with distance. Therefore, a standard for spacing between adjacent grooves in the microstrip line can be suggested by analysing the interaction between the time‐domain pulses and the microstrip line grooves. Once such a standard is satisfied, many grooves etched along the microstrip line would no longer be distinguished by the time‐domain pulses. Such a principle and method can be used to determine the instantaneous impedance for the microstrip lines that have periodic grooves. On the other hand, when several periodic structures with different lattice constants coexist on a microstrip line, they can also be distinguished via the instantaneous impedance. A time domain reflectometer was used for measuring the instantaneous impedance of periodic microstrip lines, and the measured results are in agreement with the theoretical analysis.
Wideband single‐fed circularly polarised patch antenna
Authors: Zhang Liang , Chen Jia , Wang Wenning , Qi Zihang , Ding Tongyu
Published: November 2023

A two‐layered wideband single‐fed circularly polarised (CP) antenna is presented by the authors. A single‐fed corner‐truncated square patch with four identical rectangular matching branches acts as a bottom‐driven patch to generate CP radiation. To broaden the 3‐dB axial ratio (AR) bandwidth, a similar patch with a larger size is loaded atop the driven patch as a parasitic patch. The measured results show that the proposed CP antenna has a 17.9% impedance bandwidth from 2.13 to 2.55 GHz and an 11% 3‐dB AR bandwidth from 2.15 to 2.4 GHz, respectively. The measured total gain is 7.1 dBic. The results indicate that the proposed antenna is a good candidate for Wireless Local Area Network band applications.
Improvement of the flashover threshold of TUK pressboard by using FeO3‐based nanofluid of monoesters
Authors: Jiosseu Jean Lambert , Mengounou Ghislain Mengata , Tchamdjio Nkouetcha Emeric , Moukengue Imano Adolphe
Published: November 2023

This article deals with the improvement of the dielectric properties of TUK cellulose paper by impregnation. The experiment was carried out using a nanofluid based on vegetable oil esters and iron nanoparticles (FeO3). The insulating liquids used are palm kernel oil methyl ester (PKOME) and castor oil methyl ester (COME). The evaluation of the improvement is based on the analysis of the flashover voltage of the creeping discharges produced on the immersed paper. The tests were carried out under a positive lightning impulse voltage and for two electrode configurations. The concentrations of nanoparticles used in the experiment are 0.10 wt.%, 0.15 wt.% and 0.20 wt.%. The experimental results show that the 0.10 wt.% concentration gives the best improvement for the two electrode configurations used. The improvements are 53% for the inclined tip and 56.90% for the vertical tip in the case of COME + FeO3. For PKOME + FeO3, the results are 59.90% and 64.60%, respectively, for the two configurations.
Research on symptoms composition, time series evolution, and network visualisation of interstitial cystitis based on complex network community discovery algorithm
Authors: Pang Lei , Ding Zijun , Bian Xiaodong , Shuang Weibing
Published: November 2023

We analyzed the symptoms composition of Interstitial Cystitis (IC), the regularity of the evolution of symptoms before and after treatment, and the visualization of the community network, to provide a reference for clinical diagnosis and treatment of Interstitial Cystitis. Based on the outpatient electronic case data of 552 patients with Interstitial Cystitis, we used a complex network community discovery algorithm, directed weighted complex network, and Sankey map to mine the data of the symptoms composition of Interstitial Cystitis, the evolution of symptoms before and after treatment and the visualization of the community network, to analyze the epidemiological characteristics of interstitial cystitis symptoms in the real world. By the community division of the complex network of interstitial cystitis symptoms, We finally obtained three core symptom communities. Among them, symptom community A (bladder‐related symptoms) is the symptom community with the highest proportion of nodes (60.00%) in the complex network of Interstitial Cystitis, symptom community B (non‐bladder‐related symptoms 1) ranks second (32.00%) in a complex network of Interstitial Cystitis, and symptom community C (non‐bladder‐related symptoms 2) has the lowest proportion (8.00%). There is a complex evolutionary relationship between the symptoms of Interstitial Cystitis before and after treatment. Among the single symptoms before and after treatment, the decreased rate of Day frequency is 93.22%, and the reduced urgency rate is 93.07%. The decline rate of Nocturia was 82.33%. From the perspective of different communities, the overall symptoms of symptom community A decreased by 34.39% after treatment, the general symptoms of symptom community B decreased by 35.37%, and the prevalent symptoms of symptom community C decreased by 71.43%. In the case of using diet regulation treatment to treat bladder pain, the cure rate of bladder pain can reach 22.67%. The cure rate of burning in bladders can get 15.38% with Percutaneous Sacral neuromodulation, 96.95% with diet regulation treatment, and 100% with Percutaneous Sacral neuromodulation. When using behavioral physiotherapy to treat bladder pain, 3.57% of the patient's symptoms change to bladder discomfort; 4% of the patient's symptoms change to bladder discomfort when using oral medicine to treat bladder pain.Symptom research methods based on community findings can effectively explore the rule of symptom outcome of Interstitial Cystitis before and after treatment, and the results are highly interpretable by professionals.

The cover image is based on the Original Article Research on symptoms composition, time series evolution, and network visualisation of interstitial cystitis based on complex network community discovery algorithm by Lei Pang et al., https://doi.org/10.1049/syb2.12083
Development of a Forest Village Agriculture Farmer Dependence Model on Forest Resources for The Creation of Sustainable Economic Prosperity in The Banyumas Forest Area, Central Java Province, Indonesia
Authors: Dhani laksana Rio , Shaferi Intan
Published: November 2023

Communities that live close to forests heavily rely on the resources found there. In the KPH Banyumas setting of Central Java, the research aims to determine the likelihood of choosing to work in the forest for income and characterize the elements that impact the decision to work for forest farming and forest village agricultural farmers. The study’s findings suggest that, in the forest community, the choice of employment is influenced by the physical ability variable, but not by the risk or reward factors. The factors that impact the household income of Banyumas forest village farmers include age, labor hours, and the amount of land farmed. The number of dependents, education level, own land size, and non-forest family income factors all affect how dependent Banyumas forest village farmers are on forest resources. According to this research, it is also evident that the practice of purchasing and selling land leases that do not adhere to the regulations regarding the management period of forest areas for agricultural farmers’ businesses has prevented the forest village community institution from serving as an ideal institution for village farmers.
Food and International Relations on digital discourse during #WorldFoodSafetyDay 2023
Authors: Zarina Alimuddin Sitti , Maksum Ali , Bustami Reevany
Published: November 2023

Food is intertwined with several facets of international relations, such as commerce, economics, security, diplomacy, culture, and the environment. Recognizing the importance of food in international relations facilitates greater mutual understanding and cooperation among nations. Researching food in international relations on social media, including Twitter, is critical, especially as the world commemorates World Food Safety Day. Therefore, this research examines the hashtag #WorldFoodSafetyDay 2023 amid diverse food crises worldwide. This study used computer-assisted qualitative data analysis software (CAQDAS), especially NVivo, to undertake a content analysis of the hashtags #WorldFoodSafetyDay, which was celebrated on June 7, 2023, to better understand the food safety social media conversation. This study discovers that the majority of #WorldFoodSafetyDay-related conversations have a positive tone. Intriguingly, even though the conversation involved accounts from all over the globe, including Indonesia, Indian Twitter accounts appeared to dominate the discussion. Researching #WorldFoodSafetyDay on Twitter will provide a new perspective on the discourse on food issues in international relations.
The Potential for Cattle-Palm Integration Business Development in South Kalimantan, Indonesia
Authors: Qomariah Retna , Ilham Nyak , Rahayu Heni Sulistyawati P. , Rina Yanti D. , Lesmayati Susi
Published: November 2023

The demand for beef in the South Kalimantan region is still primarily met from outside the area. This condition is an opportunity to develop the beef cattle industry in the South Kalimantan region, supported by feed raw materials sourced from oil palm plantations through the integrated system of cattle palm. The study aims to analyze the potential of the cattle palm integration system in South Kalimantan. The data used are primary and secondary. The data were analyzed descriptively quantitatively with tabulation techniques and spatial maps, including feed potential, beef population, the potential addition of cattle population, and livestock capacity. The results showed that the ratio of palm plantation land area in South Kalimantan to the cattle population was 2.68, and the ability to accommodate cattle in oil palm plantation areas was 2,752,990 livestock units/ha/year. Based on the number of cattle units in South Kalimantan of 111,461 heads, the holding capacity cattle in oil palm plantations, and the number of livestock units that have been cultivated with the cattle palm integration system in South Kalimantan 4%, then the oil palm plantation area is still able to accommodate 96% from the capacity or additional potential of cattle as much as 2.641.529 heads/ha/year.
Performing Demand Management Strategy on Palm Sugar Supply Chain in Kutai Kartanegara Regency’s Commodities
Authors: Astuti Wisudayati Tri , Charity Hidayat Dian
Published: November 2023

Unfortunately, there are unsolved critical issues of demand in a palm sugar supply chain, such as a propensity for the mismatch of demand and supply due to no local livelihood sustainability, inconsistency in handling palm sugar quality, and inappropriate institutional mechanisms. Highlighting the problems and proposing demonstrated “demand management”, this research draws on empirical evidence from case studies. The case study evidence based on the conceptual framework is drawn exclusively from Tuana Toha Village, in the Peatland Hydrological Unit area in Kutai Kartanegara Regency, where palm sugar potential is generally more mature than in other districts of Kutai Kertanegara Regency. So, this research objective proposes a comprehensive instrument of “demand management” for stabilizing the palm sugar supply chain through the improvement framework for the demand management process. The research method by participatory observation involves researchers actively participating to understand better the role and activities of micro-enterprises/ local communities in the development of palm sugar. This method can help identify problems and challenges that may not see through other research methods. Establishing four stages in the improvement framework for the demand management process: stage of definition, distribution, diagnosis, and execution. This research’s essential results state that collaboration, information sharing, and cooperatives are instruments to meet supply and demand efficiently.
Internal Evaluation Study of “Kampung Santan” Tourist Village in Bantul Yogyakarta
Authors: Sutrisno  , Achmad Yulianto , Resiana Titin , Susiyanto  , Tjale Malose Moses
Published: November 2023

This study aims to determine internal evaluation of the management “Kampung Santan” tourist village. Internal evaluation is carried out based on the internal assessment of the community in Santan Village. The evaluated performances are attractions, ancillary, accessibility, and amenities. Evaluation is measured by giving an assessment score against its ideal performance. Kampung Santan was chosen with the consideration that it had been selected as a tourist village with the best management team (POKDARWIS) in Bantul district. The respondents of this study were the people of Kampung Santan, who were selected based on the representation of existing social groups. The results of the study describe the performance of accessibility, ancillary, and amenities as a good category, but the performance of attraction is in the middle category. To complete this study, an evaluation study of tourism village management is needed, especially from external parties or visitors to tourist villages.
Analysis of Silkworm Farming Business in Partnership with CV Kupu Sutera Pasuruan East Java
Authors: Rahmawati Nur , Habibah Muthahiroh Adzra Nur , Fairuz Ramli Mona
Published: November 2023

Silkworms are insects or moths that spawn high-quality thread. In general, this insect is beneficial in the production of silk fabrics. This fabric has tremendous economic worth; thus, many people are interested in cultivating silkworms. This research aimed to determine the costs, production, revenue, profits, and feasibility (RC ratio) of silkworm farming in Pasuruan, East Java. Descriptive analysis was employed in this study. The study was conducted in a community of silkworm farmers in Pasuruan in partnership with CV Kupu Sutera. A total of 72 people were considered as respondents. The findings revealed that: 1) silkworm farming production factors included eggs, labor, cage and equipment depreciation, and transportation fuel. 2) A business analysis was performed per silkworm production cycle, with a cost of IDR 37,646, dry cocoon output of 1.79 kg, wet cocoon production of 0.229 kg, revenue of IDR 453,225, and silkworm profit of 449,579. 3) The R/C on the silkworm farming business was 12.03. This rate indicated that for every IDR 1.00 spent cost, the silkworm farmer earns IDR 12.03 in revenue. Silkworm farming was thus feasible in Pasuruan, East Java.
Laviosing: Virtual Reality (VR) 360 0 Videos as A Marketing Strategy Promotion of Village Tourism
Authors: Yunikawati Nur Anita
Published: November 2023

360-degree virtual reality (VR) video is used in tourism marketing but is still uncommon in Indonesia. This technology is viewed as an efficient tourism marketing strategy since it provides users with an immersive, enjoyable, and unforgettable experience that cannot be attained through other conventional media. Osing Tourist Village in Banyuwangi Regency is one of the tourist villages that has utilized 360-degree video as a marketing tool. Hence, it is essential to test the marketing effect of deploying VR 360 based on virtual reality and then move to consumers’ tourism-related buy intentions. This study investigates the experiential marketing variables influencing a person’s decision to visit Osing Tourist Village extensively. Sensing, emotion, thought, and action were the factors used in this study. A total of 178 participants aged 20 to 55 years were surveyed. This study used the Partial Least Square (PLS) data analysis technique. The results indicated that the determinant variables of experiential marketing (sense, feel, think, and act) had a considerable and beneficial impact on visitors’ purchase intentions. The ramifications of this study can be utilized as a point of reference for future research so that the use of virtual reality (VR) 360-degree videos can be implemented in many additional Indonesian tourist communities.
Chemical Characteristics and Sensory Analysis of Cake Enriched Pumpkin Flour to Improve Food Security
Authors: Waryat  , Sunarmani  , Kurniasih Titin
Published: November 2023

Pumpkin contains a lot of vitamins A, B, and C, as well as minerals and carbohydrates. The use of local flour as a replacement for wheat flour is still being researched. The goal of this research is to determine the quality characteristics and consumer acceptance (organoleptic) of pumpkin flour cake. The following properties were observed: proximate content (moisture content, ash content, fat, protein, and carbohydrates) and organoleptic (texture, aroma, taste, color, appearance, and overall). A completely randomized design (CRD) was used in this study, with five treatments: Wheat flour (100%, 75%, 50%, 25%) can be used in place of pumpkin flour (0%, 25%, 50%, and 75%). Pumpkin flour contained 9.30% moisture, 4.35% ash, 1.02% fat, 6.07% protein, and 4.74% fiber when used to make cakes. Pumpkin flour concentration affects the water content, ash content, fat content, protein content, and carbohydrate content of pumpkin cake. Organoleptic tests revealed that the concentration of pumpkin flour had an effect on the panelists’ pumpkin cake taste, appearance, and overall pumpkin cake. Proximate and organoleptic tests revealed that the best pumpkin-to-wheat flour ratio for baking cakes was 50%:50%. To improve family and community food security, pumpkin flour can be substituted for wheat flour.
Optimizing Growth Conditions for Green Grass Jelly (Cyclea barbata Miers) Derived in Vitro Culture: Greenhouse Acclimatization and Field Growth
Authors: Heryanto Rubi , Fatimah Syahid Sitti
Published: November 2023

Cyclea barbata Miers, a species within the Menispermaceae family, holds significance in medicinal and beverage applications. In vitro propagation is a common practice for conserving this plant; however, a comprehensive investigation of its growth characteristics within controlled greenhouse and natural field environments is essential. This study aims to determine the optimal planting media for acclimatization and the subsequent growth of Cyclea barbata Miers propagated from in vitro cultures. The experimental design encompasses two phases: 1) greenhouse acclimatization and 2) field growth. Various planting media, including combinations of sterile soil, manure, and husk charcoal, were rigorously evaluated during the acclimatization phase. Following the acclimatization period, the plants were transferred to the field. Multiple parameters were assessed: plant growth percentage, branch and node counts, leaf dimensions (length and width), and leaf wet and dry weights. Our findings reveal that a planting medium comprising sterile soil, manure, and husk charcoal provided the best performance growth outcomes during acclimatization. Furthermore, we observed that plant age exerts a discernible influence on the growth dynamics of Cyclea barbata Miers.
Diversification of Dairy-Based Food Processed Animal Product by Ice Cream Machine (ICM) at Vocational High School of Muhammadiyah Piyungan
Authors: Yudhanto Ferriawan , Sutoyo  , Padistyan Dicky Irsyad , Agustin Citravia
Published: November 2023

The rotary ice cream machine’s experiment technology improves students’ diverse food processing skills at the Department of Culinary, Vocational High School in Piyungan, Bantul. An ice cream machine (ICM) has been granted to facilitate the processing of livestock milk food products. This research provides skill training to students about making good-quality ice cream from goat milk. The ice cream machine is set at 80 rpm to turn for 20 minutes, then put 3 Kg ice block and 100 gr salt mixed into the coolant rim. Thus, the final ice cream product has a food quality standard by melting and texture tests. For the results test, the melting point of plain ice cream plain tasted has a melting time longer than chocolate tasted.
The Analysis of Tall Building Energy Performance by Using EDGE Application towards Net Zero Energy Building (NZEB)
Authors: Hajji Apif M. , Virginia Praisela , Ariestadi Dian
Published: November 2023

Net Zero Energy Building (NZEB) is one of the innovative concepts for sustainable buildings because of its ability to save energy and reduce carbon emissions simultaneously. This study used a descriptive approach to review tall building data through the parameter of saving electricity by using the EDGE application. Primary data is data obtained from working drawings or detailed engineering design (DED), work plans and specifications, and budget plans. EDGE application also produced several outputs to analyze energy performance: final energy use, operational CO2 emissions, embodied energy, utility cost, cooling loads, energy savings, operational CO2 savings, cost savings, annual EPI base case, improved EPI, number of affected people, base case and improved global warming potential of refrigerants. The EDGE also analyzed the following data: building type, site location, project details, building utility data, occupational and operational information, building dimension and specification, HVAC system, fuel used, and climate data. The energy performance of the building is analyzed by using EDGE’s parameters coded by EEM 01-37 that span from the windows-to-walls ratio to the use of low environmental impact refrigerant.
Can We Predict the Roughness Index (IRI) of a Road Based on its Pavement Condition Index (PCI)?
Authors: Pramesti Florentina Pungky , Setyawan Ary , Octavian Muhamad Calvin , Zein Aditya Putra Muhammad , Safe’i Kholid Ma’sum , Parnaningrum Kartika Novianti
Published: November 2023

Road damages might affect pavement condition which leads to reducing the remaining service life of the pavement. Two methods widely known to measure the pavement condition are among others: the Pavement Condition Index (PCI) and the International Roughness Index (IRI). Both intended to measure the functional condition of the pavement. This study aims to show the relationship between PCI and IRI, hence the road roughness can be predicted from on-foot survey measurements. It will start by collecting the distress and its severity parameter as well as the roughness of 6 road sections using Hawkeye mobile car. The car is a complete modular system to measure roughness (using profilometer), capture images and measure the severity of the road distresses and else. The results show that the pavement condition of the 6 sections fall into the category of poor and above. While 44% of the segments are fair. The roughness conditions of all road sections are good or acceptable. The correlation analysis shows that the PCI cannot necessarily explain the IRI, even though both are used to express the functional condition of road pavements, because what Hawkeye measures for the two indices is different.
Genetische Diagnostik und molekulare Ansätze bei pulmonalarterieller Hypertonie
Authors: Eichstaedt Christina A. , Bikou Olympia , Sommer Natascha , Schermuly Ralph T. , Pullamsetti Soni S. , Weissmann Norbert , Harbaum Lars , Tabeling Christoph , Wißmüller Max , Foris Vasile , Kuebler Wolfgang M. , Hinderhofer Katrin , Olschewski Andrea , Kwapiszewska Grazyna
Published: November 2023

Die kürzlich erschienenen, neuen Leitlinien für pulmonale Hypertonie bieten den bisher ausführlichsten Einblick in die genetische Diagnostik und Beratung von PAH-Patient*innen. Aber auch der Stellenwert des klinischen Screenings von gesunden Anlageträger*innen wird hervorgehoben sowie der genetischen Testung bei Patient*innen mit dem Verdacht auf eine pulmonal veno-okklusive Erkrankung. Die jeweiligen Abschnitte der Leitlinien werden im Folgenden in die aktuelle Datenlage eingebettet und kommentiert. Abschließend geben wir einen Ausblick auf neue molekulare Ansätze von Sotatercept über Ionenkanäle bis hin zu neuen therapeutischen Ansatzpunkten.
Chronisch thromboembolische pulmonale Hypertonie (Gruppe 4)
Authors: Guth Stefan , Wilkens Heinrike , Halank Michael , Held Matthias , Hobohm Lukas , Konstantinides Stavros , Omlor Albert , Seyfarth Hans-Jürgen , Schäfers Hans-Joachim , Mayer Eckhard , Wiedenroth Christoph B.
Published: November 2023

Die chronisch thromboembolische Lungengefäßerkrankung (CTEPD) ist eine wichtige Spätfolge der akuten Lungenembolie, bei der die Thromben in fibröses Gewebe transformiert werden, mit der Gefäßwand verwachsen und zu chronischen Obstruktionen führen. Man unterscheidet die CTEPD ohne pulmonale Hypertonie (PH) mit einem pulmonalarteriellen Mitteldruck bis 20 mmHg von der Form mit PH. Hierbei spricht man weiterhin von chronisch thromboembolischer pulmonaler Hypertonie (CTEPH).

Liegt der Verdacht auf eine CTEPH vor, sollten initial eine Echokardiografie und eine Ventilations-/Perfusions-Szintigrafie erfolgen, um Perfusionsdefekte nachzuweisen. Danach empfiehlt sich die Zuweisung zu einem CTEPH-Zentrum, wo weitere bildgebende Diagnostik und eine Rechtsherzkatheteruntersuchung erfolgen, um die Diagnose zu sichern und das Therapiekonzept festzulegen.

Drei Therapieoptionen stehen aktuell zur Verfügung. Therapie der Wahl ist die pulmonale Endarteriektomie (PEA). Für nichtoperable Patient*innen oder Patient*innen nach PEA und residueller PH, gibt es eine gezielte medikamentöse PH-Therapie sowie das interventionelle Verfahren der pulmonalen Ballonangioplastie (BPA). Zunehmend werden PEA, BPA und die medikamentöse Therapie im Rahmen multimodaler Konzepte kombiniert.

Alle Patient*innen müssen nachgesorgt werden, was vorzugsweise in (CTE)PH-Zentren erfolgen sollte. Für CTEPH-Zentren werden eine Mindestanzahl von PEA-Operationen (50/Jahr) und BPA-Interventionen (100/Jahr) gefordert.