bluuebunny/crossref_metadata_2025 huggingface dataset:
Quantum Kerr- (A) Ds Galilean Myers– Perr driven gravitational transformations for the anti-COVID-19 RoccuffirnaTM drug design.
Authors: Grigoriadis Ioannis
Published: January 2024

General methods to quantize reference frame transformations, to a
“superposition of coordinate transformations” have been previously
introduced on an array of recent observations developed through
gravitational amplification of primeval density fluctuations generated
in the exceedingly early phase of cosmic evolution. In this paper, we
strongly combine machine learning characteristics to Quantum Kerr- (A)
dS-Myers–Perry black microBlackHole-Inspired Gravitational for both
Euclidean and Lorentzian signatures in Practice. I provide algorithms by
means of mean percentile free energy ranking, in a new recall-based
evaluation metric for the generation of an anti-COVID-19 small molecule
combination of RoccuffirnaTM, RoccuttirnaTM, and EplerotiffirnaTM anti-
(nCoV-19) ligands. In this paper, I show that the notion of entanglement
and superposition are observer-dependent features in quantum circuit
reference frames including Galilean trans formation, and near-horizon
symmetries ranging from supergravity theories to Lorentzian
cryptographic signatures to enhance the RoccuffirnaTM’s gravity to trap
the SARS-COV-2 viruses in practice.
Exceptional genetic differentiation at a micro-geographic scale in Apistogramma agassizii (Steindachner, 1875) in the Peruvian Amazon: sympatric speciation?
Authors: Estivals Guillain , Duponchelle Fabrice , Garcia-Davila Carmen , Römer Uwe , Mariac Cedric , Renno Jean-François
Published: January 2024

Mechanisms related to ecological or sexual selection have favoured
sympatric speciation events in African and Central American lake
cichlids. Allopatric divergence is the predominant speciation process
observed in Amazonia, although, to the best of our knowledge, no study
to date has attempted to determine whether speciation process could
exist under sympatric conditions in Amazonian cichlids. The
Apistogramma agassizii species complex is an excellent model for
investigating the existence of sympatric divergence events in the
Amazon, as it shares many common life history characteristics with
African Haplochromine cichlids in which sympatric speciation mechanisms
are well documented. The genetic structure of A. agassizii was
analysed by genotyping 889 individuals with ten microsatellite loci,
collected from 26 sites distributed among small streams in 11
micro-basins in a very small portion of the Peruvian Amazon. It revealed
22 genetic populations identified according to panmictic criteria
(F estimator) and strongly differentiated:
F estimator (0.034 to 0.356). Such a strong genetic
structuring on such small geographical areas has never been demonstrated
before in an Amazonian fish. Several of these populations may have
diverged sympatrically and repeatedly in small stream networks. The
results are discussed with respect to divergence processes, including
sympatric speciation, that may be associated with the observed genetic
structure.
Remotely provided open-label placebo reduces frequency of and impairment by allergic symptoms
Authors: Kube Tobias , Kirsch Irving , Glombiewski Julia A. , Witthöft Michael , Bräscher Anne-Kathrin
Published: January 2024

Background: Placebos being prescribed with full honesty and
disclosure (i.e., open-label placebo = OLP) have been shown to reduce
symptom burden in a variety of conditions. With regard to allergic
rhinits, previous research provided inconclusive evidence for the
effects of OLP, possibly related to a separate focus on either symptom
severity or symptom frequency. Overcoming this limitation of previous
research, the present study aimed to examine the effects of OLP on both
the severity and frequency of allergic symptoms. Methods: In a
randomized-controlled trial, patients with allergic rhinits (
N=74) were randomized to OLP or treatment as usual (TAU). Due to
the COVID-19 pandemic, OLP was administered remotely in a virtual
clinical encounter. Participants took placebo tablets for 14 days. The
primary outcomes were the severity and frequency of allergic symptoms.
The secondary endpoint was allergy-related impairment. Results:
OLP did not significantly improve symptom severity over TAU, F(1,
71) = 3.280, p = .074, ɳ² = .044, but did
reduce symptom frequency, F(1, 71) = 7.272, p = .009, ɳ²
= .093, and allergy-related impairment more than TAU,
F(1, 71) = 6.445, p = .013, ɳ² = .083,
reflecting medium to large effects. The use of other anti-allergic
medication did not influence the results. Conclusions: While
OLP was able to lower the frequency of allergic symptoms and
allergy-related impairment substantially, its effects on symptom
severity were weaker. The remote provision of OLP suggests that physical
contact between patients and providers might not be necessary for OLP to
work.
Glimpse of atmospheric and room temperature plasma (ARTP) mutagenesis technology in the past decade
Authors: Zong Xuyan , Wen Lei , Wang Xiangyu , Li Li
Published: January 2024

Atmospheric and room temperature plasma (ARTP) mutagenesis technology
have a rapid development in recent years due to advantages of simple
operation, safety, environmental-friendly, high mutation rate,
large-capacity mutation library, etc. It has been applied in the fields
of food, agriculture and medicine. Data of 167 articles, related to ARTP
mutagenesis technology from 2011 to 2021, were collected from the Web of
Science Core Collection (WOSCC), visually analyzed the keyword and
reference of articles by CiteSpace. Several research hotspots of ARTP
mutagenesis technology were found.
Incidentally detected Castleman disease of the thorax and its surgical management
Authors: Khanna Sudhansoo , Singh Rana , Goyal Priyanka , Mohan Harsh , Bhaker Poonam , Rana Shaleen , Sanga Sunil
Published: January 2024

Castleman disease (CD) is a rare lymphoproliferative disorder, the
etiology and pathogenesis of which is not clearly established. It
presents more commonly as a localised disease or unicentric CD (UCD),
and less often as generalised disease or multricentric CD (MCD). The
most common site of UCD is in the thorax; however, UCD is rarely
included in the differential diagnosis of an intrathoracic mass due to
its rarity. The lesion is highly vascular and often has dense adhesions
with adjacent organs, making the surgery a difficult task. We report a
case of posterior mediastinal mass located in left paraspinal region
which was detected incidentally in a 53-year old female and was
subsequently resected successfully via left postero-lateral thoracotomy,
and was diagnosed post-operatively on histopathological examination
(HPE) as CD, hyaline vascular variant (HVV). We review the relevant
clinical, pathological and radiological findings of CD, which may act as
clinical pointers for establishing a preoperative diagnosis of CD.
Suspecting CD preoperatively would guide the surgeon for appropriate
surgical planning and may avoid facing such surprise on the operating
table.
Efficacy of elexacaftor/tezacaftor/ivacaftor in decreasing severe cystic fibrosis-related exacerbations: a retrospective, within-group study
Authors: Rhudy Christian , Kormelink Lauren , Taylor Brittany , Hegnauer Sarah , Autry Elizabeth , Zeltner Matthew , Platt Thom
Published: January 2024

Elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) is the newest CFTR
modulator approved for patients with cystic fibrosis. In randomized
controlled trials, ELX/TEZ/IVA showed benefit at 24 weeks in terms of
lung function, respiratory symptoms, pulmonary exacerbations and weight.
However, long-term clinical benefit of ELX/TEZ/IVA in real-world
settings is still being investigated. Methods This retrospective
within-groups study examined cystic fibrosis patients receiving care
from a single academic health-system specialty pharmacy. Subjects were
included who initiated ELX/TEZ/IVA and continued therapy for greater
than one year. Retrospective data from the index year prior to
ELX/TEZ/IVA initiation and the year following was collected by medical
records review. The primary end point was the difference in number of
severe cystic fibrosis exacerbations in index year as compared to the
year post ELX/TEZ/IVA initiation. Results A total of 76 patients were
included in the final analysis. In the post- ELX/TEZ/IVA year, subjects
had a significant mean decrease in severe exacerbations (-0.72; 95% CI
-0.43, -1.02; p<0.0001). Decreases in severe exacerbations
remained significant in subgroups of patients with prior CFTR exposure
(-0.56; 95% CI -0.22, -0.91; p =0.002; n=46) and moderate to severe
lung disease (-0.98; 95% CI -0.49, -1.45; p = 0.0002; n=41). After one
year of ELX/TEZ/IVA therapy, subjects experienced a significant mean
absolute increase in ppFEV1 of 6.07% (between-years difference 4.47%;
95% CI 0.58, 8.37; p=0.025) and increase in BMI of 1.46 (between-years
difference 1.29; 95% CI 0.65, 1.95; p=0.0002). Conclusion One year of
ELX/TEZ/IVA therapy was associated with sustained improvements in
clinical status of cystic fibrosis patients.
Unusual Case of Histiocyte-Rich Rhabdomyoblastic Tumor in a Pediatric Patient
Authors: Krskova Lenka , Šípalová BArbora , Balko Jan , Zimová Simona , Voříšková Dagmar , Broz Petr , Kodet Roman , Vícha avicha
Published: January 2024

Histiocyte-rich skeletal rhabdomyoblastic tumor (HR-RMT) is a rare
recently described skeletal muscle neoplasm of uncertain malignant
potential. We report an unusual tumor in the right arm of a 5-year-old
boy, which is the first case of a pediatric HR-RMT.
Immunohistochemically, most cells in the tumor were positive for CD163
and CD68 staining. The neoplastic cells themselves showed a skeletal
muscle phenotype with diffuse expression of desmin and focal expression
of myoD1. Mitotic activity was low (1/10 HPF) and no necrosis was
observed.
Low genetic variability and high isolation of a post-harvest South American pinniped population as revealed by genome-wide SNPs
Authors: Peralta Diego , Ibañez Ezequiel , Lucero Sergio , Cappozzo Humberto , Ceballos Santiago , Túnez Juan
Published: January 2024

Otaria flavescens is one of the most heavily exploited pinnipeds during
the last 200 years, with depletions of about 90% in some colonies.
After the prohibition on sealing in South America, most populations
stabilized at lower levels than in the pre-harvest period, but with an
increasing trend over a wide distribution range. An exception is given
by the Uruguayan population, which is constantly decreasing. The
underlying causes of its decline have remained unknown. This study used
the RAD-seq approach to assess the variability and connectivity of some
of the most overexploited sea lion colonies in the Atlantic Ocean. This
powerful methodology, which allowed us to characterize thousands of
SNPs, is used here for the first time in a pinniped from South America.
Our results revealed low allelic richness and heterozygosity in the
Uruguayan population, suggesting the occurrence of a very recent
population bottleneck event. Moreover, we found evidence that this
population is totally isolated from the Argentinean populations under
study, reducing the chance of recovery even further. Our work raises
awareness of the critical situation for the Uruguayan sea lion
population and calls for the immediate implementation of conservation
measures.
Compositional resistance and successional reversal after long-term experimental drought in biocrust communities
Authors: Faiffer María Cristina Rengifo , Bowker Matthew , Antoninka Anita , Reed Sasha , Duniway Michael , Belnap Jayne , Coe Kirsten , Fisher Kirsten , Mishler Brent , Oliver Melvin , Stark Lloyd
Published: January 2024

The effects of severe drought on the stability of dryland ecosystems are
still uncertain and it is unknown whether diversity can buffer changes
in systems that are adapted to water-limitation. We investigated the
effects of long-term induced drought on the composition and maturity of
biological soil crusts (biocrusts), as well as tested the hypothesis
that diversity promotes stability using compositional resistance as a
measure for ecosystem stability. We surveyed an array of 25 sites in the
central Colorado Plateau, USA, that included plots that received ambient
precipitation and plots that had experienced eight years of
~35% precipitation reduction. We found that biocrusts
can maintain broad compositional integrity after long-term climate
disturbance. However, biocrust successional reversal still occurred,
with a reduction of later successional constituents and an increase of
early successional cyanobacterial cover. Our findings indicate that
long-term drought could have major impacts on biocrust community
stability.
Case Report: A Rare Case of Metronidazole Overdose Causing Ventricular Fibrillation
Authors: Elgassim Mohamed , Elgassim Moayad , Saied Amin , Abdelrahman Amro , Al-Jaufi Ibtesam , Salem Waleed
Published: January 2024

Most arrhythmias associated with Metronidazole overdose are related to
the co-ingested drugs as Metronidazole affects the metabolism of these
drugs. In this case, ventricular fibrillation occurred in a young
patient who overdosed on Metronidazole without preexisting medical
conditions or any other known drug ingestion, which was never reported
before
Rose flavor compound b-damascone regulates dendritic cell-mediated immunoresponses by modulating the NRF2 pathway and ameliorates contact hypersensitivity
Authors: Kodama Naoki , Okada Hikaru , Nagata Kazuki , Ando Miki , Ito Naoto , Yashiro Takuya , Ichihara Gaku , Yamamoto Masayuki , Hachisu Masakazu , Nishiyama Chiharu
Published: January 2024

Background: Numerous pharmacologically beneficial compounds
have been isolated from natural products derived from plants; these
compounds are often characterized as phytochemicals and are used in
flavors, spices, fragrances, and colors. In the current study, we aimed
to obtain novel immunomodulators from aroma compounds. Methods:
We selected a candidate that inhibits antigen-presenting cell-mediated
activation of T cells from an aroma library. The molecular mechanisms by
which the candidate compound modulates immunoresponses were analyzed
with in vitro studies, and the biological significance of the
candidate was evaluated by using a mouse model. Results:
b-Damascone, a major ingredient of rose fragrance, was selected from an
aroma library as a candidate compound that suppresses antigen-dependent
T cell activation, through 2-step screening using OT-II splenocytes.
Investigations using flow cytometry, ELISA, and qPCR revealed that
b-damascone inhibited dendritic cell (DC)-related responses, including
DC-induced Th1 development, TLR ligand-induced transactivation and
production of inflammatory cytokines in DCs, and LPS-induced
upregulation of MHC class II and CD86 on DCs. Regarding intracellular
events, we found that b-damascone treatment increased the levels of NRF2
protein and Hmox1 mRNA in DCs. Nrf2
DCs, in which b-damascone-induced Hmox1 transcription was not
observed, possessed Th1-induction activity and higher IL-12p40
production activity even in the presence of b-damascone in comparison
with Nrf2 DCs. Finally, we evaluated the
effect of orally administered b-damascone on the pathology of contact
hypersensitivity model mice and found that b-damascone intake suppressed
ear swelling. Conclusions: The rose aroma compound b-damascone,
which suppresses DC-mediated immunoresponses by activating the NRF2
pathway, could be useful to ameliorate immunorelated diseases.
Characteristics of Patients with Head and Neck Cancer Diagnosed at Autopsy
Authors: Ramsey Tam , Ostrowski Tyler , Gildener-Leapman Neil , Galati Lisa
Published: January 2024

Objectives: Thyroid cancers with low T-stage and nodal burden are common
incidental findings at autopsy; however, less is known about the
frequency of non-thyroid head and neck cancers diagnosed at autopsy. It
is important to identify the prevalence of various head and neck cancers
found at autopsy and their association with morality as cancers differ
in risk factors and severity. Design: Head and neck cancers excluding
cutaneous malignancy were identified in the Surveillance, Epidemiology,
and End Results database. Case-related data was reviewed to characterize
the demographic factors associated with the head and neck cancers found
at autopsy. Fisher’s Exact Test was used to identify correlations
between cancer-related mortality and cancer type. Results: We reviewed
678 cases of head and neck cancers diagnosed at autopsy from 2000 to
2017. The most common causes of death found at autopsy in non-thyroid
carcinoma were cancer-related mortality (51.40%), heart disease
(14.95%), and accidents (5.61%). Thyroid carcinoma was the cause of
death in 17 (3.01%) patients. The top three causes of death in this
group were heart disease (26.19%), accident (9.20%), and infection
(6.19%). Patients with non-thyroid cancer were 17.1 (95% CI: 9.55 -
30.6, p < 0.001) times more likely to have cancer-related
death than those with thyroid carcinoma. Conclusion: The high rate of
cancer-related deaths in postmortem diagnosis of non-thyroid head and
neck cancers reveals the need for physicians to increase detection
vigilance and emphasizes the need to improve screening in those who may
be high risk for disease development or progression.
Calcium/Calmodulin Modulates Salt Responses through Binding a Novel Interacting Protein SAMS1 in Peanut ( Arachis hypogaea L.)
Authors: Li Xin-Guo , Yang Sha , Wang Jianguo , Tang Zhaohui , Li Yan , Zhang Jialei , Guo Feng , Wan Shu-Bo
Published: January 2024

Ca /CaM signal transduction pathway is well known to
help plants to adapt to the environmental stress. However, our knowledge
on the function proteins of Ca /CaM pathway in
peanut remains limited. Here, using yeast two hybrid methods, we
identified a novel calmodulin4 (CaM4) binding protein
S-adenosyl-methionine synthetase1 (SAMS1) in peanut. The expressions of
AhSAMS1 were obviously induced by Ca , ABA
and salt stress. To elucidate the function of AhSAMS1, physiological and
phenotypic analyses were applied between wild type and transgenic
materials. Overexpression of AhSAMS1 significantly increased Spd
and Spm synthesis while decreased the contents of ethylene, thus
eliminating excessive ROS in the transgenic lines under salt stress.
Consistent with the induced expressions of SOS and NHX
genes, AhSAMS1 reduced the uptake of Na and the
leakage of K from mesophyll cells, and was less
sensitive to salt stress during early seedling growth. Transcriptomics
combined with epigenetic regulation uncovered the relationships between
DEGs and DMRs, which raised the salt tolerance and plants growth.
Together, our findings support a model in which the role of AhSAMS1 on
ROS-dependent regulation of ion homeostasis was enhanced by Ca
/CaM while AhSAMS1-induced methylation was regulated
by CaM, thus providing a novel strategy to enhance plant salt tolerance.
Laparoscopic management of cornual ectopic pregnancy: A step-by-step approach
Authors: Kalampokas Emmanouil , Giannis Giorgos , Kalampokas Theodoros , Triantafyllidou Olga , Vlahos Nikolaos
Published: January 2024

Interstitial and cornual pregnancies remain the most difficult types of
ectopic pregnancy to diagnose and treat. Traditionally, the treatment of
interstitial pregnancy has been interventional; a surgical approach that
may even extend to a hysterectomy or uterine cornual resection via
laparotomy. Recently, and hopefully increas¬ingly, more conservative
approaches have been suggested, such as cornuostomy instead of cornual
resection and laparoscopy in place of laparotomy, for preserving uterine
integrity for future fertility. We present a step-by-step surgical
approach that we have implemented in cases of cornual pregnancy in our
department.
Cricoid chondronecrosis: a serious complication of prolonged endotracheal intubation
Authors: BIJOU Walid , Oukessou Youssef , Laachoubi Mohamed , Rouadi Sami , Abada Reda , Roubal Mohamed , Mahtar Mohamed
Published: January 2024

Cricoid chondronecrosis is a rare life-threatening complication of
endotracheal intubation. Herein we present a patient with a history of
severe brain injury, who developed a cricoid chondronecrosis after ICU
stay. We discuss the diagnosis of the condition, the causative factors,
treatment through a literature review.
Ivacaftor alters macrophage and lymphocyte infiltration in the lung following lipopolysaccharide exposure
Authors: Harwood Kiera , McQuade Rachel , Jarnicki Andrew , Schneider-Futschik Elena
Published: January 2024

Background and Purpose: Cystic fibrosis (CF) is associated with a myriad
of respiratory complications including increased susceptibility to lung
infections and inflammation. Progressive inflammatory insults lead to
airway damage and remodelling, resulting in compromised lung function.
Treatment with ivacaftor significantly improves respiratory function and
reduces the incidence of pulmonary exacerbations; however, its effect on
lung inflammation is yet to be fully elucidated. Experimental approach:
This study investigates the anti-inflammatory effects of ivacaftor in
the lung post lipopolysaccharide (LPS) exposure and compare effects of
prophylactic and therapeutic ivacaftor treatment in a C57BL/6 mice
model. All groups received intratracheal (IT) administration of LPS (10
ug). Prophylactic treatment involved intraperitoneal injections of
ivacaftor (40mg/kg) once a day beginning 4 days prior to LPS challenge.
The therapeutic group received a single intraperitoneal ivacaftor
injection (40mg/kg) directly after LPS. Mice were culled either 24h or
72h post LPS challenge and serum, bronchoalveolar lavage fluid (BALF)
and lung tissue samples were collected. The degree of inflammation was
assessed through cell infiltration, cytokine expression and histological
analysis. Key Results: Ivacaftor did not alter the total number of
immune cells within the BALF, however, prophylactic treatment did
significantly alter macrophage and lymphocyte infiltration. Prophylactic
treatment saw a significant negative correlation between immune cell
number and ivacaftor concentrations in BALF, however, no significant
changes in cytokine expression nor histological parameters were
determined. Conclusion & Implications: Ivacaftor possesses some
inherent immunomodulatory effects within the lung following LPS
inoculation, however, further analysis of larger sample sizes is
required to confirm results.
Malnutrition in a child with T-cell ALL leading to Superior Mesenteric Artery syndrome and Wernicke's encephalopathy
Authors: Rao Harini , Barron Mary , Biswas Asthik , Branson Helen , Mitton Gregory , Naqvi Ahmed
Published: January 2024

We report the case of a child with T-cell ALL who presented with
clinical features of SMA syndrome and Wernicke’s encephalopathy,
concurrently, in the setting of malnutrition and significant weight
loss. We highlight the importance of an early clinical diagnosis of
these two uncommon but treatable complications of malnutrition in
childhood cancer.
Suspected adverse events following immunization against SARS-CoV2 in a university hospital in 2021
Authors: Rodriguez Dolores , Ordoñez Pilar , Llop Roser , Videla Sebastian , Otero Aurema , Carnaval Thiago , Poltorak Violeta , Moya-Guerola Miguel , Masuet Cristina , Rodriguez Soledad , Hereu Pilar
Published: January 2024

Aim: Vaccination against SARS-CoV2 has been proposed as a fundamental
element for the control of the pandemic. The aim of this study is to
describe the suspected adverse reactions (ADRs) reported among
vaccinated hospital workers. Methods: Descriptive study of suspected
ADRs identified between January and March 2021. The suspected ADRs were
identified by specifically designed electronic form and by spontaneous
reporting. Data was also collected regarding the characteristics of the
professionals, vaccine administered, severity, and outcome of the ADR.
Results: 8,169 professionals received the two doses of SARS-CoV2 vaccine
(6,672 Comirnaty® and 1,497 Spikevax®) and 894 reports of suspected ADR
were reported (762 for Comirnaty® and 132 for Spikevax®), so a
cumulative AEFIs incidence of 10.94% (95%CI: 10.27-11.62). The
majority of ADRs were reported only after the second dose, 497(56.2%)
while 211 (23.6%) was reported only after the first dose and a 186
(21%) after both doses. Symptoms were mostly mild, did not require
medical assistance and disappeared in about 3 days. One hundred and
seventeen professionals had a history of COVID-19. These reported,
statistically significant, more suspected ADRs after the first dose
(42.7%) than professionals with no history of COVID-19 (20.7%). Among
the professionals, more ADRs occurred after the first dose with the
Spikevax® vaccine (41.6%) than with the Comirnaty® vaccine (20.5%).
Conclusion: The majority of the suspected ADRs reported were those
described in the summary of product characteristics (SmPC).
Professionals with history of COVID-19 reported more suspected ADRs
after the first dose than professionals without history.
Dynamic behaviors of abundant solutions for the Lakshmanan--Porsezian--Daniel equation in an optical fiber
Authors: Guo Han-Dong , Xia Tiecheng , Wei Hanyu
Published: January 2024

The integrable Lakshmanan–Porsezian–Daniel (LPD) equation originating
in nonlinear fiber is studied in this work via the Riemann–Hilbert (RH)
approach. Firstly we perform the spectral analysis of the Lax pair along
with LPD equation, from which a RH problem is formulated. Afterwards,
using the symmetry relations of the potential matrix, the formula of
N-soliton solutions can be obtained by solving the special RH problem
with reflectionless under the conditions of irregularity. In particular,
the localized structures and dynamic behaviors of the breathers and
solitons corresponding to the real part, imaginary part and modulus of
the resulting solution r(x,t) are shown graphically and discussed in
detail. One of the innovations in the paper is that the higher-order
linear and nonlinear term β has important impact on the velocity, phase,
period, and wavewidth of wave dynamics. The other is that collisions of
the high-order breathers and soliton solutions are elastic interaction
which imply they remain bounded all the time.
N-doped Hierarchical ZrO2@Carbon Nano-network Anchored Ultrafine Pd Nanoparticles for Efficient Catalytic Hydrogenation
Authors: Pu Chun , Li Rui dong , Chang Ganggang , Chen Minjie , Yao Yao , Li Junsheng , Zhao Bo , Wu Lu , Zhang Yuexing , Yang Xiao-Yu
Published: January 2024

Carbon supported metal catalysts have received considerable interest due
to their widespread applications in heterogeneous catalysis. However,
the controllable synthesis of carbon support with defined morphology and
composition still represents great challenging. Herein, we reported the
synthesis of a well-defined hierarchically nanosized H-ZrO2/NC
(nitrogen-doped carbon) network via inheritable carbonization strategy.
When immobilizing the palladium clusters into the support, the N-doped
sites and oxygen vacancy of the carbon composite can effectively
stabilize and activate Pd through strong host-guest interaction which
was also confirmed by DFT calculations. Moreover, the hierarchically
nanosized network can contribute to the exposure of active sites and
facilitate the mass transfer during the catalytic process. As a result,
benefiting from the hierarchical structure, composition and hydrolytic
nature, Pd@H-ZrO2/NC exhibited excellent catalytic activity and
stability towards the hydrogenation of furfural in mild reaction
conditions, as well as good universality toward the hydrogenation of a
series of unsaturated hydrocarbons.
Mathematical modeling for molten ash slagging moving bed coal gasifier considering the impact of bed characteristics
Authors: Zhang Quancong , Wei Bin , Cao Zhikai , Chen Bing Hui , Xue Kang , Zhou Hua
Published: January 2024

Molten ash slagging moving bed gasification technology is significant
for lump coal utilization. Mathematical modeling is essential for a
comprehensive understanding of transport and reaction phenomena in a
gasifier. In this work, a model based on the impact of bed
characteristics was proposed, encompassing: (i) particle fragmentation
and agglomeration varied the particle size and bed voidage, (ii) gas
channeling weakened the gas-solid heat transfer efficiency and variation
of the gas phase temperature, and (iii) molten ash covering coal surface
attenuated the gas-solid reaction rate. A good agreement was found
between the simulation results of the proposed model and industrial
data. Finally, the effects of the operating and model parameters were
studied. The results indicated that the steam flow rate had a
significant influence on the product gas composition, and the
temperatures of gas and solid phases were sensitive to the gas
channeling factor.
Simultaneous Detection and Identification of Peste des petits ruminants Virus Types Ⅱ and Ⅳ by MCA-Based Real-Time RT-qPCR Assay within Single Reaction
Authors: Tang Jingyu , Du Hanyu , Jia Nannan , Tang Aoxing , Li Chuanfeng , Meng Chunchun , Liu Guangqing
Published: January 2024

Peste des petits ruminants (PPR) disease is a cross-species infectious
disease that severely affects small ruminants and causes great losses to
livestock industries in various countries. Distinguishing
vaccine-immunized animals from naturally infected animals is an
important prerequisite for the eradication of PPR.
[ ](javascript:void(0);)Although peste des petits ruminants virus
(PPRV) was currently divided into lineages I-IV and only one vaccine
strain N75 belongs to type II, its epidemic strains in China all belong
to lineage IV. As to achieve this goal, we developed an SYBR Green I
real-time RT-qPCR method for rapid detection and differentiation of PPRV
lineage II and IV by analyzing different melting curve analyses. Primers
targeting the L gene were highly specific, as evidenced by the negative
amplification of closely related viruses, such as Orf virus, goat
poxvirus, and Foot-and-mouth disease virus. The sensitivity of the assay
was assessed based on plasmid DNA and the detection limit achieved was
10 copies of PPRV-II and PPRV-IV respectively. As the method has high
sensitivity, specificity, and reproducibility, which will be significant
in effectively controlling the occurrence and transmission of PPRV.
Maternal antenatal vitamin D supplementation and offspring risk of atopic eczema in the first 4 years of life
Authors: El-Heis Sarah , D’Angelo Stefania , M Elizabeth Curtis , Healy E. , J Rebecca Moon , Crozier Sarah , Inskip Hazel , Cooper Cyrus , Harvey Nicholas , Godfrey Keith
Published: January 2024

Background Evidence linking prenatal maternal vitamin D
supplementation and offspring risk of atopic eczema is inconsistent,
with most data coming from observational studies. Methods
Within the UK Maternal Vitamin D Osteoporosis Study (MAVIDOS)
double-blind, randomised, placebo-controlled trial, we examined the
relation of maternal vitamin D supplementation during pregnancy with
offspring atopic eczema at ages 12, 24 and 48 months. In MAVIDOS,
pregnant women were allocated to either cholecalciferol 1000 IU/day or
matched placebo, taken from around 14 weeks’ gestation until delivery,
with the primary outcome of neonatal whole-body bone mineral content.
The prevalence of atopic eczema in the offspring was ascertained at ages
12 (n=636), 24 (n=611) and 48 (n=450) months, based on the UK Working
Party Criteria for the Definition of Atopic Dermatitis. Results
Mothers and offspring characteristics were similar between the
intervention and placebo groups, apart from longer breastfeeding
duration in the intervention group. Adjusting for breastfeeding
duration, offspring of mothers who received 1000 IU cholecalciferol
daily had a lower odds ratio (OR) of atopic eczema at age 12 months: OR
(95%CI) 0.55 (0.32-0.97), p=0.04. The ORs of atopic eczema in the
intervention group at ages 24 and 48 months were 0.77 (0.47-1.24) and
0.71 (0.35-1.43), respectively. Conclusion Our data
demonstrated a clinically important reduction in offspring risk of
atopic eczema in infancy following maternal cholecalciferol
supplementation during pregnancy. The findings support a developmental
influence on infantile atopic eczema and point to gestational
cholecalciferol supplementation as a preventive strategy to reduce the
burden of atopic eczema during infancy.
Overexpression of the isopentenyl diphosphate isomerase gene increases triterpenoids production in Sanghuangporus baumii
Authors: Liu Zengcai , Bahetibieke Wumuti , Wang Shixin , Sun Tingting , Zou Li
Published: January 2024

Sanghuangporus baumii is a traditional medicinal fungus that
contains triterpenoids with important pharmacological effects. However,
the level of triterpenoids produced by S. baumii is far below the
level demanded for application, and the pathway of triterpenoids
biosynthesis is poorly understood. In this study, we established an
Agrobacterium tumefaciens-mediated transformation system for the
first time and transferred the key gene isopentenyl diphosphate
isomerase ( IDI) involved in triterpenoids biosynthesis into
S. baumii. The transcript level of IDI and the total
triterpenoids content of the IDI transformant (IT) strain were
significantly increased with respect to the wild-type (WT) strain. Then,
we investigated the individual triterpenoids contained in S.
baumii using metabolome and found 10 individual triterpenoids. All
individual triterpenoids produced by IT strain showed the upward trend,
were 1.76-10.03 times higher than those produced by the WT strain.
Meanwhile, those individual triterpenoids showed significant positive
correlation with the IDI gene. The findings provide valuable
information about the biosynthetic pathway of triterpenoids and provide
a strategy to cultivate S. baumii strains with high triterpenoids
content.
Cluster Analysis of Allergic Poly-Sensitizations in Urban Adults with Asthma
Authors: Patchett Brian J. , Nriagu Bede N. , Mavraj Granit , Patel Ruchi R. , MacLellan Christopher , Thakur Tushar , Schulman Edward
Published: January 2024

Introduction: While reliable  in vitro testing for sensitivity to
common aeroallergens has been available for decades, if and how asthma
might be predictably expressed in people matched for comparable multiple
sensitizations is unknown.   Objective: Our aim is to develop an
understanding of these relations, which are known as allergic
poly-sensitizations (APS) using a machine learning approach. We
performed an audit of adult urban patients with moderate to severe
asthma who presented to an urban outpatient pulmonary clinic. Methods:
We constructed a database of sensitizations to the 25 aeroallergens in
the zone 1 ImmunoCAP® assay. We used the Scikit-Learn® machine learning
library to perform model-based clustering to identify APS clusters.
Subsequently, clusters were compared for differences in clinical markers
of allergic asthma.  Results: The database consisted of 509 patients.
Mixture modeling identified ten clusters of increasing APS of varying
size (n = 1 to 339). There were significant increases in mean serum
immunoglobulin E (p<.001), peripheral blood eosinophil count
(p<.001), and D (p=.02) with increasing
APS. There was a significant decline in mean age at presentation
(p<.001), FEV /FVC (p=.01), and FEF
(p=.002), but not FEV  (p=.29),
nor RV/TLC (p=.14) with increasing APS by simple linear regression.
Finally, we identified two apparent divergent paths for the poly-atopic
march, one driven by perennial allergens and the other by seasonal
allergens.  Conclusion: We provide the framework for a novel machine
learning understanding and approach to the classification of APS and its
heretofore under-appreciated potential influences on asthma cluster
analyses. To our knowledge, this represents the first attempt to
identify poly-sensitization patterns that have clinical implications.
Population Pharmacokinetics of Voriconazole and C-reactive protein guided Dosage Optimization in Chinese Patients with Talaromyces marneffei Infection
Authors: Jiang Zhiwen , Wei Yinyi , Huang Wei-e , Li Bingkun , Zhou Siru , Li Tiantian , Liao Liuwei , Liang Tianwei , Yu Xiaoshu , Huang Xiaolu , Pan Kaisu , ZHENG Yan-qing , AL-ODAINI Najwa , Zhou Changjing , Liu Taotao , Cao Cunwei
Published: January 2024

Objective To evaluate the population pharmacokinetics of voriconazole
(VRC) and identify the factors affecting it in Chinese patients with
Talaromyces marneffei infection. Based on the final model, the optimal
dosing regimen was further investigated in these patients. Methods
Patients with talaromycosis from two hospitals who met the inclusion
criteria were enrolled. Patients’ demographic information, VRC
medication history, concomitant medications and laboratory test
information data were recorded. A population pharmacokinetic model was
developed through from the nonlinear mixed-effects models (NONMEM).
Monte Carlo Simulation was applied to optimize the initial dosing
regimens. Results A total of 146 blood samples taken from 46 patients
with talaromycosis were included in the study. A one-compartment model
was used to characterize VRC pharmacokinetics. Population estimates of
clearance (CL) and volume of distribution (V) were 2.19 L/h and 88.4L,
respectively. VRC clearance was significantly associated with C-reactive
protein (CRP) level, which causing individual pharmacokinetics
variation. CYP2C19 polymorphisms had no effect on voriconazole
pharmacokinetic parameters. Based on the dosing simulations with CRP
level, the initial dosing regimens was recommended are as follows:
loading dose 150mg q12h 1day followed by maintenance dose 100mg q12h
intravenous for CRP< 40mg/L, and loading dose 75mg q12h
followed by maintenance dose 50mg q12h intravenous for CRP ≥ 40mg/L.
Conclusion A population pharmacokinetic model of VRC was successfully
established in patients with Talaromyces marneffei infection. CRP was
identified to significantly affect VRC plasma concentration. Optimizing
initial dosing regimens according to the CRP level may be useful to
guide VRC dosing in clinical practice.
PhenoWell® – A novel screening system for soil-grown plants
Authors: Li Ji , Mintgen Michael A.C. , D’Haeyer Sam , Helfer Anne , Nelissen Hilde , Inzé Dirk , Dhondt Stijn
Published: January 2024

As agricultural production is reaching its limits regarding outputs and
land use, the need to further improve crop yield is greater than ever.
The limited translatability from in vitro lab results into more
natural growth conditions in soil remains problematic. Although
considerable progress has been made in developing soil-growth assays to
tackle this bottleneck, the majority of these assays use pots or whole
trays, making them not only space- and resource-intensive, but also
hampering the individual treatment of plants. Therefore, we developed a
flexible and compact screening system in which individual seedlings are
grown in wells filled with soil. The combination of an insert plate,
containing the wells, with an adapter plate, containing reservoirs,
allows for single-plant irrigation, different liquid treatments and
mimicking stress conditions. The system makes use of an automated
image-analysis pipeline that extracts multiple growth parameters from
individual seedlings over the time course of the experiment, including
projected rosette area, relative growth rate, compactness, and
stockiness. The system is also optimized for maize with results that are
consistent with Arabidopsis while different in amplitude. We conclude
that the PhenoWell® system enables the translation of results obtained
from in vitro studies into useful applications in soil.
Cautionary Tale of Right Ventricular Perforation during Micra TM leadless pacemaker insertion.
Authors: Gulkarov Iosif , H Louis Stein , Karanam Ravindra , Lackey Adam , Merlino John A. , Dobesh David , Ahmad Ahsanuddin , Salemi Arash
Published: January 2024

Transcatheter pacing systems are self-contained, leadless, devices that
offer the potential benefits of avoiding complications related to
pectoral pocket and upper extremity vascular access. These systems in
preapproval trials demonstrated excellent safety profile with the
incidence of device related cardiac perforation as low as 1.6% with
Micra (Medtronic, Minneapolis, MN) and 1.3% in
Nanostim (Abbott, Abbott Park, IL). In post approval registry of Micra
TPS the rate of major complications was even lower
than in investigational study ranging from 0.63 to 0.77%. Recently,
published report found a much higher rates of need for rescue surgery,
shock, tamponade, and death among patients implanted with the Micra
device when compared with transvenous devices. This
case reports describes two cases of major right ventricular perforation
requiring surgical intervention.
Association between genetic polymorphisms in SLC19A1, SLCO1B1 and SLCO1B3 genes predicts survival and toxicity in North Indian lung cancer patients undergoing platinum-based doublet chemotherapy
Authors: Sharma Parul , Singh Navneet , Sharma Siddharth
Published: January 2024

Abstract Aims: SLC transporters are expressed in lungs and are essential
membrane proteins responsible for the transport of wide range of
chemotherapeutic drugs. Polymorphisms in SLC19A1, SLCO1B1, and SLCO1B3
gene in North Indian lung cancer patients are investigated. Methods: A
total of 610 lung cancer patients undergoing platinum-based chemotherapy
were recruited in the study. Polymorphisms of SLC19A1 (G80A), SLCO1B1
(A388G, T521C) and SLCO1B3 (A1683-5676G) in North Indian lung cancer
patients were assessed and statistical analysis were carried out.
Results: Our data revealed that patients harboring mutant genotype (AA)
for SLC19A1 G80A polymorphism had higher MST as compared patients with
wild type (GG) genotype (MST=9.33 versus 8.23). ADCC patients with
mutant genotype (AA) showed better survival outcomes for SLC19A1 G80A
(MST=9.4 versus 8.8, HR=0.6; p=0.04). In SCLC, SLC19A1 G80A polymorphism
revealed increased survival in the patients harboring mutant genotype
(AA) (MST=9.6 months versus 7.6 months, p=0.04). For SLCO1B3
polymorphism, patients administered with carboplatin/cisplatin and
docetaxel showed inferior survival outcomes in subjects carrying
heterozygous alleles (AG) (MST=2.9 months versus 9.6 months, p=0.006,
HR=14.01). For anemia, SLCO1B1 T521C showed that patients with
heterozygous genotype (TC) had a reduced risk of developing anemia
(OR=0.44, 95% CI=0.20-0.96; p=0.04). Patients with SLCO1B1 A388G
polymorphism harboring AG alleles was associated with a lower incidence
of thrombocytopenia (OR=0.41, 95% CI=0.20-0.82; p=0.01). Patients with
heterozygous (AG) genotype (OR=0.35, 95% CI=0.17-0.72; p=0.002) for
A1683-5676G polymorphism showed lower incidence of nephrotoxicity.
Conclusion: Genotyping of SLC polymorphism is crucial for predicting
survival and toxicity in lung cancer patients undergoing platinum-based
chemotherapy.
Efficacy of Helical Tomography (HT) with Concurrent Chemoradiotherapy (CCRT) +Epidermal growth factor receptor (EGFR) inhibitor in Locally advanced nasopharyngeal carcinoma (LANC) patients invading carotid artery and risk of fatal bleeding
Authors: liu kun , wang Yang , Ma Lin , Yang SM , Zhang Xinxin
Published: January 2024

Abstract: Objectives: Are LANC patients with carotid artery invasion are
at risk of massive neck hemorrhage after radiotherapy? Design: This
retrospective study aims to assess the efficacy of HT with CCRT +/-EGFR
inhibitor in LANC patients invading carotid artery and risk of fatal
bleeding. Settings: Otolaryngology Head and Neck Surgery department in
our hospital in China . Participants: Of 130 LANC patients with carotid
artery invasion admitted to our hospital between January 2012 and
September 2019. Main outcome measures: The 5-year survival rate of three
degrees of the carotid artery invasion (<180°,
180°≤IG<270°, ≥270°) . Univariate and Multivariate Cox
regression analysis were used for survival correlation factors. Results:
The incidence of fatal bleeding after radiotherapy was 2.3% (3/130).
The primary site of the three cases were all the pharyngeal recess, with
more than 270º carotid artery invasion. Patients with hemoglobin levels
>110 g/L had a higher PFS, DMFS and OS than with that ≤110
g/L (P<0.05). Multivariate analysis showed that the EGFR
inhibitor was an independent risk factor for PFS and DMFS, while the
lowest hemoglobin level was an independent risk factor for OS.
Conclusion: In LANC patients whose carotid artery invasion was
<270º, HT combined with CCRT and EGFR inhibitor after
induction chemotherapy had mild and tolerable side effects, better PFS
and DMFS, with no massive hemorrhage. In patients ≥270º, diabetes with
poor control or re-radiotherapy led to a higher risk of massive
hemorrhage after radiotherapy.
On the performance of Hirschman Optimal Transform Pre-coded UFMC for reduction of PAPR
Authors: Reddy K. Ashoka , Krishna E. Hari
Published: January 2024

Universal filtered multi carrier (UFMC) system is considered to be the
best choice for 5G waveform when compared with orthogonal frequency
division multiplexing (OFDM), filtered OFDM (f-OFDM), filter bank multi
carrier (FBMC) and generalized FDM (GFDM) in terms of spectral leakage,
complexity and compatibility with 5G. The all multi carrier systems are
suffers from high peak to average power ratio (PAPR) causes non linear
functioning in receiver. In this paper, we proposed a Hirschman optimal
transform (HOT) based pre-coding for reducing the PAPR in UFMC systems.
Results reveals that HOT pre-coded UFMC promising less PAPR compared
with discrete cosine transform (DCT), discrete Hartley transform (DHT)
and discrete sine transform (DST) and discrete Fourier transform (DFT).
3D‐fluid‐attenuated inversion recovery MR images in sudden hearing loss: audio vestibular correlations.
Authors: Lee Seung Hwan , Byun Hayoung , Chung Jae Ho , Lee Ha Na
Published: January 2024

Objective This study aimed to investigate correlation between 4‐hour
delayed‐enhanced 3.0 Tesla (3T) 3D‐fluid‐attenuated inversion recovery
(FLAIR) MR images and audio-vestibular function in idiopathic sudden
sensorineural hearing loss. Setting Tertiary center Methods All patients
underwent 4‐hour delayed‐enhanced 3D‐FLAIR MR imaging for identifying
lesion-side laterality and enhanced labyrinth patterns. Audiologic and
vestibular function tests were performed. Vestibular function test sum
scores were additionally calculated by summing the scores on each test
and defining normal as 0 and abnormal as 1. The hearing recovery was
evaluated according to the American Academy of Otolaryngology-Head and
Neck Surgery Criteria at 3 months after the end of treatment. Results
Lesion-side laterality was identified in 31 (40.8%) of the 76 patients
with ISSNHL and these patients had a lower hearing recovery rate
(P<0.05). Furthermore, patients with a lower initial hearing
threshold (dB), word recognition score, and lesion-side posterior
semicircular canal gain displayed poorer hearing recovery
(P<0.05). Initial hearing threshold and word recognition score
did not change significantly as the extent of the enhancement in the
labyrinth increased; however, the probability of being accompanied by
vertigo and the total score on the vestibular function tests did
increase (P<0.05). Conclusions Lesion-side laterality of the
labyrinth in ISSNHL can be identified on 4-hour delayed-enhanced 3DFLAIR
MR images. The extent of enhancement in the labyrinth is associated with
clinical findings such as impaired audio-vestibular function, and also
with the prognosis of ISSNHL. Keywords: Idiopathic sudden sensorineural
hearing loss, 4-hour delayed 3D FLAIR MRI, Audiovestibular function,
Prognosis. Level of Evidence; 4