bluuebunny/crossref_metadata_2025 huggingface dataset:
Deepfake Detection Algorithm Based on Dual-Branch Data Augmentation and Modified Attention Mechanism
Authors: Wan Da , Cai Manchun , Peng Shufan , Qin Wenkai , Li Lanting
Published: July 2023

Mainstream deepfake detection algorithms generally fail to fully extract forgery traces and have low accuracy when detecting forged images with natural corruptions or human damage. On this basis, a new algorithm based on an adversarial dual-branch data augmentation framework and a modified attention mechanism is proposed in this paper to improve the robustness of detection models. First, this paper combines the traditional random sampling augmentation method with the adversarial sample idea to enhance and expand the forged images in data preprocessing. Then, we obtain training samples with diversity and hardness uniformity. Meanwhile, a new attention mechanism is modified and added to the ResNet50 model. The improved model serves as the backbone, effectively increasing the weight of forged traces in the multi-scale feature maps. The Jensen–Shannon divergence loss and cosine annealing algorithms are introduced into the training process to improve the model’s accuracy and convergence speed. The proposed algorithm is validated on standard and corrupted datasets. The experiments show that the algorithm proposed in this paper significantly improves effectiveness and robustness, with accuracies of 4.16%, 7.37%, and 3.87% better than the baseline model on DeepFakes, FaceSwap, and FaceShifer, respectively. Most importantly, its detection performance on the corrupted datasets DeepFakes-C, FaceSwap-C, and FaceShifer-C is much higher than that of mainstream methods.
Dynamic Response Analysis of Wind Turbine Structure to Turbulent Wind Load: Comparative Assessment in Time and Frequency Domains
Authors: Kelele Hailay Kiros , Kahsay Mulu Bayray , Nielsen Torbjørn Kristian
Published: July 2023

This study investigates wind turbine structural dynamics using stochastic analysis and computational methods in both the time and frequency domains. Simulations and experiments are utilized to evaluate the dynamic response of a wind turbine structure to turbulent wind loads, with the aim of validating the results based on real wind farm conditions. Two approaches are employed to analyze the dynamic responses: the frequency domain modal analysis approach, which incorporates von Kármán spectra to represent the turbulent wind loads, and the time domain Monte Carlo simulation and Newmark methods, which generate wind loads and determine dynamic responses, respectively. The results indicate that, for a larger number of samples, both methods consistently yield simulated turbulent wind loads, dynamic responses and peak frequencies. These findings are further validated through experimental data. However, when dealing with a smaller number of samples, the time domain analysis produces distorted results, necessitating a larger number of samples to achieve accurate findings, while the frequency domain method maintains accuracy. Therefore, the accurate analysis of wind turbine structural dynamics can be achieved using simulations in both the time and frequency domains, considering the importance of the number of samples when choosing between time domain and frequency domain analyses. Taking these considerations into account allows for a more comprehensive and robust analysis, ultimately leading to more effective outcomes.
Spatial–Temporal Variations in Temperature and Precipitation Extremes during 1960–2019 in Guizhou Province, China
Authors: Xue Xu , Hou Shuangshuang , Meng Chuncan
Published: July 2023

Under the background of global warming, climate extremes have become a crucial issue with distinct heterogeneity features in different regions. Hence, spatial–temporal changes in temperature and precipitation extremes in Guizhou Province were investigated utilizing daily maximums and minimums of temperature and daily precipitation data during 1960–2019 based on trend analysis. It was concluded that, firstly, all warm extremes but warm spell duration indicator (WSDI) are significantly enhanced, whereas for cold extremes, the monthly minimum value of daily minimum temperature (TNn) is significantly enhanced, while cool nights (TN10P), frost days (FD0), ice days (ID0), and cold spell duration indicator (CSDI) are significantly decreased. And all precipitation extremes but consecutive wet days (CWD) have no significant variational trend in Guizhou Province. Secondly, variational trends of temperature extremes are more prominent and robust in western Guizhou Province. Temperature and precipitation extremes show large differences from spring to winter. Thirdly, temperature extremes are closely correlated with strength, area, and the westernmost ridge point index of western Pacific subtropical high (WPSH), whereas precipitation extremes show no distinct correlation with WPSH. The WPSH has significantly strengthened and shifted westward in the past 60 years, leading to less total cloud cover and more downward solar wave flux reaching Earth’s surface, accordingly, exacerbating warm extremes and weakening cold extremes. These results will benefit understanding the heterogeneity of climate extremes at a regional scale.
Association between Third Mobile Window Disorders and Symptom Reduction Using a Noise Cancelling Device: Inverse Tullio Phenomena
Authors: Feinberg Debby , Rosner Mark , Gianoli Gerard
Published: July 2023

Identifying a vestibular source of pathology in patients complaining of post-traumatic brain injury (TBI) dizziness can be difficult. We describe a possible new method utilizing a reduction in post-TBI symptoms (including dizziness) with the use of a noise cancellation device (NCD). This retrospective case series included patients with TBI and dizziness presenting to a binocular vision specialty clinic, who were diagnosed with a vertical heterophoria (VH). If they did not respond adequately to microprism lenses and/or if they experienced hyperacusis, they were evaluated with an NCD. If there was marked reduction in TBI symptoms (including dizziness), the patients were referred to a neuro-otologist for vestibular diagnostic evaluation and treatment. Fourteen patients were identified and found to have abnormalities on vestibular testing consistent with third mobile window disorder (TMWD). All were treated with a 6-week medical protocol (diuretics, no straining, low sodium/no caffeine diet). Five responded positively, requiring no further treatment. Nine required surgical intervention and responded positively. In conclusion, in 14 patients with post-concussive dizziness and VH, a positive response to NCD was associated with abnormal vestibular testing, a diagnosis of TMWD, and symptom reduction/resolution with a medical or surgical approach. The removal of sound resulting in reduction or resolution of vestibular symptoms represents an inverse Tullio phenomenon.
Neural Networks for the Detection of COVID-19 and Other Diseases: Prospects and Challenges
Authors: Azeem Muhammad , Javaid Shumaila , Khalil Ruhul , Fahim Hamza , Althobaiti Turke , Alsharif Nasser , Saeed Nasir
Published: July 2023

Artificial neural networks (ANNs) ability to learn, correct errors, and transform a large amount of raw data into beneficial medical decisions for treatment and care has increased in popularity for enhanced patient safety and quality of care. Therefore, this paper reviews the critical role of ANNs in providing valuable insights for patients’ healthcare decisions and efficient disease diagnosis. We study different types of ANNs in the existing literature that advance ANNs’ adaptation for complex applications. Specifically, we investigate ANNs’ advances for predicting viral, cancer, skin, and COVID-19 diseases. Furthermore, we propose a deep convolutional neural network (CNN) model called ConXNet, based on chest radiography images, to improve the detection accuracy of COVID-19 disease. ConXNet is trained and tested using a chest radiography image dataset obtained from Kaggle, achieving more than 97% accuracy and 98% precision, which is better than other existing state-of-the-art models, such as DeTraC, U-Net, COVID MTNet, and COVID-Net, having 93.1%, 94.10%, 84.76%, and 90% accuracy and 94%, 95%, 85%, and 92% precision, respectively. The results show that the ConXNet model performed significantly well for a relatively large dataset compared with the aforementioned models. Moreover, the ConXNet model reduces the time complexity by using dropout layers and batch normalization techniques. Finally, we highlight future research directions and challenges, such as the complexity of the algorithms, insufficient available data, privacy and security, and integration of biosensing with ANNs. These research directions require considerable attention for improving the scope of ANNs for medical diagnostic and treatment applications.
A Scoping Review on Coping Strategies and Quality of Life of Stroke Caregivers: Often Underestimated Variables in Stroke Recovery Process?
Authors: Tsiakiri Anna , Vlotinou Pinelopi , Paschalidou Aikaterini , Konstantinidis Christos , Christidi Foteini , Tsiptsios Dimitrios , Detsaridou Georgia , Petridou Alexandra , Gkantzios Aimilios , Karatzetzou Stella , Tsamakis Konstantinos , Giannakou Erasmia , Emmanouilidou Maria , Vadikolias Konstantinos , Aggelousis Nikolaos
Published: July 2023

The purpose of the present study was to review all available work published within the last decade focusing on coping strategies in stroke caregivers and their impact on quality of Life (QoL) and psycho-emotional status. A literature search of two databases (MEDLINE, Scopus) was conducted to identify all relevant full-text English studies published between 2013–2023. Sixteen articles were traced and were finally included. Cognitive and behavioral coping strategies were beneficial for stroke caregivers’ and survivors’ QoL. The level of mutuality in the caregiver-survivor relationship was associated with the impact of depressive symptoms on caregivers’ QoL and the protective effect of mutuality on survivors’ QoL over time. The level and quality of social support were positively associated with QoL for stroke caregivers and survivors. Caregivers’ preparedness was a moderator for the impact of depression on both caregivers’ and survivors’ QoL. High levels of spirituality had a significant role in ameliorating the negative impact of depressive symptoms on the psychological and physical QoL of stroke caregivers and survivors. In conclusion, the study of coping strategies can be used as a psychological reserve in the process of stroke rehabilitation and actively contribute to improving the QoL of both caregivers and stroke survivors.
BIM-Based Automated Multi-Air Distribution Layout Generation for Office Buildings: A Case Study
Authors: Qi Zixuan , Jin Ruiying , Li Junjie , Guan Hang , Xu Peng
Published: July 2023

Although HVAC (Heating Ventilation, and Air Conditioning) layout design has transitioned from 2D drawings to 3D BIM models, the traditional manual process of sizing and placing terminal units is still a time-consuming task, which can lead to inappropriate airflow and wastage of resources due to human error. The purpose of this paper is to develop a highly robust method for sizing and placing HVAC terminal units in rooms, while also systematically avoiding obstacles based on the locations of air terminal units and FCUs (Fan Coil Units) to which they belong. The method employs a “scan” approach to solve the problem of insufficient robustness caused by the traditional grid division method. Rule-based iterative algorithms are utilized for the sizing of terminals, airflow verification, and obstacle avoidance to generate a complete set of FCU and CAV (Constant Air Volume) system terminal layouts within a building. The method was tested for the automated design of HVAC terminal layouts in six different buildings and successfully completed the task within seconds, demonstrating the method’s immediacy and robustness. Moreover, airflow organization tests showed that the terminal layouts generated by the algorithm had a 95% pass rate, indicating the effectiveness of the method.
Structurally Rigid (8-(Arylimino)-5,6,7-trihydroquinolin-2-yl)-methyl Acetate Cobalt Complex Catalysts for Isoprene Polymerization with High Activity and cis-1,4 Selectivity
Authors: Yousuf Nighat , Ma Yanping , Mahmood Qaiser , Zhang Wenjuan , Liu Ming , Yuan Rongyan , Sun Wen-Hua
Published: July 2023

A series of cobalt complexes bearing (8-(arylimino)-5,6,7-trihydroquinolin-2-yl)methyl acetate ligand framework were prepared using a one-pot synthesis method. These complexes were then extensively investigated for their catalytic performance in isoprene polymerization. In addition to the complexes being characterized via FT-IR spectrum and elemental analysis, the molecular structure of Co1 and Co5 was determined via X-ray diffraction analysis. The analysis revealed a chloride-bridged centrosymmetric binuclear species in which each cobalt center exhibited a distorted square pyramidal geometry. Among the prepared complexes, Co1 demonstrated the highest catalytic activity of 1.37 × 105 g (mol of Co)−1(h)−1, achieving complete monomer conversion and resultant polyisoprene showed high molecular weight (Mn ≥ 2.6 × 105 g/mol). All of the complexes showed preference for the cis-1,4 configuration ranging from 65% to 72%, while the 3,4 monomer insertion units constituted between 27% and 34% of the polymer structure. Moreover, extensive investigations were conducted to assess the impact of reaction parameters and ligand properties on the catalytic activities and microstructural characteristics of the resulting polymer.
GBA Regulates EMT/MET and Chemoresistance in Squamous Cell Carcinoma Cells by Modulating the Cellular Glycosphingolipid Profile
Authors: Clark Laura E. , Dickinson Amanda J. G. , Lima Santiago
Published: July 2023

Glycosphingolipids (GSL) are plasma membrane components that influence molecular processes involved in cancer initiation, progression, and therapeutic responses. They also modulate receptor tyrosine kinases involved in EMT. Therefore, understanding the mechanisms that regulate GSLs in cancer has important therapeutic potential. One critical regulator of GSLs is the lysosomal glucosylceramidase β1 (GBA) that catalyzes the last step in GSL degradation. We show that, in cancer, GBA copy number amplifications and increased expression are widespread. We show that depleting GBA in squamous cell carcinoma cell lines results in a mesenchymal-to-epithelial shift, decreased invasion and migration, increased chemotherapeutic sensitivity, and decreased activation of receptor tyrosine kinases that are involved in regulating EMT. Untargeted lipidomics shows that GBA depletion had significant effects on sphingolipids and GSLs, suggesting that increased GBA activity in cancer sustains EMT and chemoresistance by modulating receptor tyrosine kinase activity and signaling via effects on the cellular lipid profile.
Macromolecule Translocation across the Intestinal Mucosa of HIV-Infected Patients by Transcytosis and through Apoptotic Leaks
Authors: Krug Susanne M. , Grünhagen Carolin , Allers Kristina , Bojarski Christian , Seybold Joachim , Schneider Thomas , Schulzke Jörg-Dieter , Epple Hans-Jörg
Published: July 2023

Based on indirect evidence, increased mucosal translocation of gut-derived microbial macromolecules has been proposed as an important pathomechanism in HIV infection. Here, we quantified macromolecule translocation across intestinal mucosa from treatment-naive HIV-infected patients, HIV-infected patients treated by combination antiretroviral therapy, and HIV-negative controls and analyzed the translocation pathways involved. Macromolecule permeability was quantified by FITC-Dextran 4000 (FD4) and horseradish peroxidase (HRP) flux measurements. Translocation pathways were addressed using cold inhibition experiments. Tight junction proteins were characterized by immunoblotting. Epithelial apoptosis was quantified and translocation pathways were further characterized by flux studies in T84 cell monolayers using inducers and inhibitors of apoptosis and endocytosis. In duodenal mucosa of untreated but not treated HIV-infected patients, FD4 and HRP permeabilities were more than a 4-fold increase compared to the HIV-negative controls. Duodenal macromolecule permeability was partially temperature-dependent and associated with epithelial apoptosis without altered expression of the analyzed tight junction proteins. In T84 monolayers, apoptosis induction increased, and both apoptosis and endocytosis inhibitors reduced macromolecule permeability. Using quantitative analysis, we demonstrate the increased macromolecule permeability of the intestinal mucosa in untreated HIV-infected patients. Combining structural and mechanistic studies, we identified two pathways of increased macromolecule translocation in HIV infection: transcytosis and passage through apoptotic leaks.
The Melanocortin System in Inflammatory Bowel Diseases: Insights into Its Mechanisms and Therapeutic Potentials
Authors: Gravina Antonietta Gerarda , Pellegrino Raffaele , Durante Tommaso , Palladino Giovanna , Imperio Giuseppe , D’Amico Giovanbattista , Trotta Maria Consiglia , Dallio Marcello , Romeo Mario , D’Amico Michele , Federico Alessandro
Published: July 2023

The melanocortin system is a complex set of molecular mediators and receptors involved in many physiological and homeostatic processes. These include the regulation of melanogenesis, steroidogenesis, neuromodulation and the modulation of inflammatory processes. In the latter context, the system has assumed importance in conditions of chronic digestive inflammation, such as inflammatory bowel diseases (IBD), in which numerous experiences have been accumulated in mouse models of colitis. Indeed, information on how such a system can counteract colitis inflammation and intervene in the complex cytokine imbalance in the intestinal microenvironment affected by chronic inflammatory damage has emerged. This review summarises the evidence acquired so far and highlights that molecules interfering with the melanocortin system could represent new drugs for treating IBD.
Coatings Prepared by Electro-Spark Alloying with SHS Electrode Materials Based on Ti-B-Fe-AlN
Authors: Bolotskaia Anastasia , Avdeeva Varvara , Bazhin Pavel , Mikheev Maksim , Stolin Alexander , Novikov Vseslav , Kovaleva Marina , Sirota Viacheslav
Published: July 2023

In this work, the features of the phase composition, structures, and properties of coatings obtained on a high-speed steel substrate (steel R6M5) were studied. The coatings were prepared using the ESA method (electro-spark alloying). Electrode materials prepared through self-propagating high-temperature synthesis (SHS) based on (Ti-B-Fe)xAlN with the addition of nanosized AlN particles in the amount of x = 0.5, 10, 15 wt % were used as electrodes. The structure, phase composition, and physical and mechanical properties of the SHS electrode materials are reported. It was found that the coatings inherited the structure of the SHS electrode material and formed two characteristic zones for x = 0 and three zones for x = 5, 10, 15. The surface hardness of the substrate made of the high-speed steel R6M5 with the developed coatings was found to increase up to five times compared to the uncoated substrate. It was found that the wear resistance of the samples with the coating was four to six times higher than that of uncoated samples.
Leaping Forward or Crawling Backward? Efforts and Biases in Amphibian and Reptile Research on a Megadiverse Faunal Region in the Philippines
Authors: Abdullah Sumaira S. , Cruz Kier Celestial Dela , Casim Lothy F. , Agduma Angelo Rellama , Tanalgo Krizler Cejuela
Published: July 2023

Research efforts to protect Philippine biodiversity have increased significantly. However, there is an imbalance in the distribution of published studies, with specific territories receiving more attention than others. Mindanao, a southern Philippine group of islands, is known for its high levels of endemism for amphibians and reptiles. Despite this, research on these groups remains scattered. To address this gap, we conducted a literature review focusing on amphibians and reptiles in the Mindanao faunal region. We found an increasing effort towards herpetofauna over the two decades, yet there is a clear bias in the effort towards amphibians compared to reptiles. Furthermore, we found that amphibians have a significantly higher species threat index than reptiles and all other vertebrate groups, regardless of species endemism and conservation status. Yet, threatened herpetofauna species and those facing greater threats are poorly studied in general. Understanding the factors driving research biases in Mindanao and the Philippines is essential to allow us to redirect research efforts to the most needed areas, particularly understudied and neglected taxa in Mindanao. This is especially urgent in the face of a changing climate, where diverse herpetofauna communities are at an increased risk of extinction. Consequently, by bridging these gaps in biodiversity information, we can effectively contribute to the conservation and understanding of biodiversity in the region.
Free-Breathing and Single-Breath Hold Compressed Sensing Real-Time MRI of Right Ventricular Function in Children with Congenital Heart Disease
Authors: Treutlein Christoph , Zeilinger Martin Georg , Dittrich Sven , Roth Jan-Peter , Wetzl Matthias , Heiss Rafael , Wuest Wolfgang , May Matthias Stefan , Uder Michael , Rompel Oliver
Published: July 2023

(1) Purpose: to compare right ventricular (RV) functional parameters in children with surgically repaired congenital heart disease (CHD) using single/double breath hold (BH) and free-breathing (FB) real-time compressed sensing (CS) cine cardiac magnetic resonance (cMRI) with standard retrospective segmented multi breath hold (RMB) cine cMRI. (2) Methods: Twenty patients with CHD underwent BH and FB, as well as RMB cine cMRI, at 3T to obtain a stack of continuous axial images of the RV. Two radiologists independently performed qualitative analysis of the image quality (rated on a 5-point scale; 1 = non-diagnostic to 5 = excellent) and quantitative analysis of the RV volume measurements. (3) Results: The best image quality was provided by RMB (4.5; range 2–5) compared to BH (3.9; range 3–5; p = 0.04) and FB (3.6; range 3–5; p < 0.01). The RV functional parameters were comparable among BH, FB, and RMB with a difference of less than 5%. The scan times for BH (44 ± 38 s, p < 0.01) and FB (24 ± 7 s, p < 0.01) were significantly reduced compared to for RMB (261 ± 68 s). (4) Conclusions: CS-FB and CS-BH real-time cine cMRI in children with CHD provides diagnostic image quality with excellent accuracy for measuring RV function with a significantly reduced scan time compared to RMB.
Characterization of Mandibular Border Movements and Mastication in Each Skeletal Class Using 3D Electromagnetic Articulography: A Preliminary Study
Authors: Farfán Nicole Constanza , Lezcano María Florencia , Navarro-Cáceres Pablo Eliseo , Sandoval-Vidal Héctor Paulo , Martinez-Gomis Jordi , Muñoz Loreto , Marinelli Franco , Fuentes Ramón
Published: July 2023

Mandibular movement recording is relevant for the planning and evaluation of mandibular function. These movements can include mandibular border movements (MBM) or mastication. Our objective was to characterize the kinematics of MBM and mastication among skeletal classes I, II, and III in the three spatial planes. A descriptive cross-sectional study was conducted with 30 participants. Instructions were provided on how to form Posselt’s envelope and to perform masticatory. After data processing, we obtained numerical values for the areas, trajectories, and ranges of MBM that formed Posselt’s envelope and the values for speed, masticatory frequency, and the areas of each masticatory cycle. Significant differences were found in the area of Posselt’s envelope in the horizontal plane between skeletal classes I and III and in the range of right laterality between skeletal classes II and III. Mastication showed significant differences in the area of the masticatory cycles in the horizontal plane between classes I and III and between classes II and III. In conclusion, there were differences in MBM and mastication between skeletal classes III and I in the horizontal plane. This study supports the need to establish normal values for mandibular kinematics in skeletal class III.
Microsimulation Modelling and Scenario Analysis of a Congested Abu Dhabi Highway
Authors: Hasan Umair , AlJassmi Hamad , Hasan Aisha
Published: July 2023

Today’s roadways are subject to traffic congestion, the deterioration of surface-assets (often due to the overreliance on private vehicle traffic), increasing vehicle-operation and fuel costs, and pollutant emissions. In Abu Dhabi, private car traffic forms the major share on urban highways, as the infrastructure was built to a high quality and the public transport network needs expansion, resulting in traffic congestion on major highways. These issues are arguably addressable by appropriate decisions at the planning stage. Microsimulation modeling of driving behavior in Abu Dhabi is presented for empirical assessment of traffic management scenarios. This paper presents a technique for developing, calibrating, validating, and the scenario analysis of a detailed VISSIM-based microsimulation model of a 3.5 km section of a 5-lane divided highway in Abu Dhabi. Traffic-count data collected from two sources, i.e., the local transport department (year 2007) and municipality (2007 and 2015–2016) were used. Gaps in traffic-counts between ramps and the highway mainline were noted, which is a common occurrence in real-world data situations. A composite dataset for a representative week in 2015 was constructed, and the model was calibrated and validated with a 15% (<100 vehicles per hour) margin of error. Scenario analysis of a potential public bus transport service operating at 15 min headway and 40% capacity was assessed against the base case, for a 2015–2020 projected period. The results showed a significant capacity enhancement and improvement in the traffic flow. A reduction in the variation between vehicle travel times was observed for the bus-based scenario, as less bottlenecking and congestion were noted for automobiles in the mainline segments. The developed model could be used for further scenario analyses, to find optimized traffic management strategies over the highway’s lifecycle, whereas it could also be used for similar evaluations of other major roads in Abu Dhabi post-calibration.
Numerical Simulation of a Space-Fractional Molecular Beam Epitaxy Model without Slope Selection
Authors: Lee Hyun Geun
Published: July 2023

In this paper, we introduce a space-fractional version of the molecular beam epitaxy (MBE) model without slope selection to describe super-diffusion in the model. Compared to the classical MBE equation, the spatial discretization is an important issue in the space-fractional MBE equation because of the nonlocal nature of the fractional operator. To approximate the fractional operator, we employ the Fourier spectral method, which gives a full diagonal representation of the fractional operator and achieves spectral convergence regardless of the fractional power. And, to combine with the Fourier spectral method directly, we present a linear, energy stable, and second-order method. Then, it is possible to simulate the dynamics of the space-fractional MBE equation efficiently and accurately. By using the numerical method, we investigate the effect of the fractional power in the space-fractional MBE equation.
Historical Use of Lime in Some Islands of the Tuscan Archipelago (Italy) Where Stone for Lime Is Almost Absent
Authors: Rescic Silvia , Fratini Fabio , Pittaluga Daniela
Published: July 2023

The Tuscan Archipelago lies between the Ligurian Sea to the north and the Tyrrhenian Sea to the south and between Corsica to the west and the Tuscan coast to the east. It is made up of seven major islands, Elba, Giglio, Capraia, Montecristo, Pianosa, Giannutri and Gorgona (in order of size), and several smaller ones. Geologically, these islands are very different from each other. Elba combines all the characteristics of the northern Apennines with a large granodioritic pluton and a sequence of tectonic units with sedimentary successions of the Ligurian and Tuscan type. Giglio is a granitic pluton with a small patch of sedimentary cover. Capraia is an entirely volcanic island. Montecristo is a granitic pluton. Pianosa consists exclusively of Mio-Pliocene carbonate rocks. Giannutri consists of Mesozoic Cavernous Limestone, and Gorgona consists of calcschists, serpentinites and metabasites. This article examines the mortars used in the historical architecture of Capraia, Gorgona and Giglio, islands where limestones are almost absent, trying to investigate the provenance of the carbonate stones used to produce the lime through mineralogy–petrographic analyses. Mineralogical and petrographic analyses proved useful in identifying the raw materials used for the production of lime, also contextualising them in the historical and administrative vicissitudes of the islands. In particular, a magnesian lime of Ligurian origin was used in Capraia during the period when the island was under the rule of the Republic of Genoa. On Gorgona in the Middle Ages, the few outcrops of carbonate rock on the island, consisting of saccaroid marble, were exploited for the local production of lime, while in later times lime was sourced from the mainland. In Giglio, the small outcrops of dolostone and marbles on the western side of the island were exploited. This work has broadened knowledge in the use of materials and highlighted man’s knowledge of the area and its resources to such an extent that even small outcrops suitable for lime production were exploited. Attention is also drawn to the fact that, although sophisticated techniques provide excellent information, in many cases only a careful petrographic investigation allows the most useful information to be obtained in a cheap and easy way.
Urban Environment of Disappeared Heritage: Graphic Analysis of Puerta Real in Seville
Authors: Gámiz-Gordo Antonio , Antón Daniel , Barrero-Ortega Pedro
Published: July 2023

The city of Seville experienced a remarkable rise in the 16th century thanks to trade with America. Based on a report by the architect Hernán Ruiz, it was decided to renovate the gates of the walled city. The Puerta Real, also called Puerta de Goles, was remodelled between 1560 and 1566, and King Philip II entered through it in 1570. However, it was demolished around 1864, and only the remains of the adjacent wall stand today. This research aims to graphically analyse the gate and its immediate surroundings to gain a more profound knowledge of it and to promote its heritage value. To this end, an extensive collection and analysis of historical images has been carried out, which are essential for understanding the transformations of the site. A photograph by Masson (c. 1855–1860) was next used to support the virtual reconstruction of the gate. A 3D laser scanner was also used to document the existing archaeological remains and, via game-engine technology, to recreate rigorously, for the first time, this 16th-century gate in its current environment. This research could be useful for future scientific reconstruction to promote the heritage revitalisation of this city area.
A New Subgenus of the Genus Phenolia (Coleoptera, Nitidulidae) from Myanmar Cretaceous Amber with Taxonomic, Phylogenetic and Bionomic Notes on the ‘Nitidulid’ Group of Families
Authors: Kirejtshuk Alexander , Shaw Josh , Smirnov Igor
Published: July 2023

A new subgenus, Palaeoronia subgen. nov., is described from the Cretaceous amber of North Myanmar (Kachin State) and assigned to the genus Phenolia. The type species of the new subgenus, Phenolia (Palaeoronia) haoranae subgen. et sp. nov., is characterized by a rather ‘archaic’ aspect. A discussion of the diagnostic and structure of the Soronia-complex of genera (together with the Phenolia-complex of genera) (Nitidulinae, Nitidulini) is proposed. Reasons for the ‘conservatism’ of this group during the Mesozoic and Cenozoic are discussed. The position of the Apophisandridae stat. nov. (type genus Apophisandra) and the transfers of the following genera into this family: Cretaretes, Electrumeretes, Furcalabratum, Pelretes, Polliniretes, Protokateretes, Protonitidula, and Scaporetes, from the Kateretidae, Nitidulidae or Cerambycidae are grounded. The relations of the family Parandrexidae (with inclusion of the genus Cretoparacucujus, transferred from Boganiidae with a proposal of the subfamily Cretoparacucujinae subfam.nov.), Martynoposis and Parandrexis are considered. The genus Antirhelus gen. nov. (type species Heterhelus buzina) is assigned to the new subfamily, Antirhelinae subfam. nov. in the family Kateretidae. The fossil records of the ‘nitidulid’ group of families (Apophisandridae stat. nov., Kateretidae, Nitidulidae, Parandrexidae, Smicripidae and possibly Boganiidae) are reviewed. The relationship of the family Boganiidae, some aspects of pollination and pollinophagy, and also changes in beetle diet in the past are discussed. The lectotype of Parandrixis parvula is designated.
Higher pNRF2, SOCS3, IRF3, and RIG1 Tissue Protein Expression in NASH Patients versus NAFL Patients: pNRF2 Expression Is Concomitantly Associated with Elevated Fasting Glucose Levels
Authors: Schwertheim Suzan , Alhardan Malek , Manka Paul P. , Sowa Jan-Peter , Canbay Ali , Schmidt Hartmut H.-J. , Baba Hideo A. , Kälsch Julia
Published: July 2023

Non-alcoholic fatty liver disease (NAFLD) embraces simple steatosis in non-alcoholic fatty liver (NAFL) to advanced non-alcoholic steatohepatitis (NASH) associated with inflammation, fibrosis, and cirrhosis. NAFLD patients often have metabolic syndrome and high risks of cardiovascular and liver-related mortality. Our aim was to clarify which proteins play a role in the progression of NAFL to NASH. The study investigates paraffin-embedded samples of 22 NAFL and 33 NASH patients. To detect potential candidates, samples were analyzed by immunohistochemistry for the proteins involved in innate immune regulation, autophagy, apoptosis, and antioxidant defense: IRF3, RIG-1, SOCS3, pSTAT3, STX17, SGLT2, Ki67, M30, Caspase 3, and pNRF2. The expression of pNRF2 immunopositive nuclei and SOCS3 cytoplasmic staining were higher in NASH than in NAFL (p = 0.001); pNRF2 was associated with elevated fasting glucose levels. SOCS3 immunopositivity correlated positively with RIG1 (r = 0.765; p = 0.001). Further, in NASH bile ducts showed stronger IRF3 immunostaining than in NAFL (p = 0.002); immunopositive RIG1 tissue was higher in NASH than in NAFL (p = 0.01). Our results indicate that pNRF2, SOCS3, IRF3, and RIG1 are involved in hepatic lipid metabolism. We suggest that they may be suitable for further studies to assess their potential as therapeutics.
The Psoriatic Arthritis 5-Thermometer Scales (PsA-5Ts): Measurement Properties of a New Multidimensional Composite Tool for the Quick Assessment of the Overall Health Status in Psoriatic Arthritis
Authors: Salaffi Fausto , Carotti Marina , Farah Sonia , Di Carlo Marco
Published: July 2023

Background: Psoriatic arthritis (PsA) is a heterogeneous condition that is difficult to assess. The goal of this research was to evaluate the clinimetric properties of the Psoriatic Arthritis 5-Thermometer Scales (PsA-5Ts), a new patient-reported outcome (PRO) to measure the overall health status in PsA patients. Methods: The PsA-5Ts were compared to composite measures of disease activity (DAPSA, PASDAS, CPDAI) and PROs (PsAID-12 and SF-36). The convergent validity was assessed through the Spearman’s correlation coefficient and the discriminant validity through the receiver operating characteristic (ROC) curve analysis, applying the Minimal Disease Activity (MDA) as an external criterion. Results: The cross-sectional assessment included 155 patients. Significant high correlations were observed when comparing PsA-5Ts to composite indices of disease activity and PROs (all at significance levels of p < 0.0001). The PsA-5Ts subscales were highly significantly different in terms of MDA status (all at p < 0.0001). The PsA-5Ts had good discriminant validity like that of the DAPSA, CPDAI, PASDAS, and PsAID-12, and better than that of the SF-36, with an area under the ROC curve of 0.944 (65% CI 0.895–0.974). Conclusions: The PsA-5Ts are an easy-to-use PRO that can be integrated with disease activity indices in the assessment of PsA in daily clinical practice.
GERPM: A Geographically Weighted Stacking Ensemble Learning-Based Urban Residential Rents Prediction Model
Authors: Hu Guang , Tang Yue
Published: July 2023

Accurate prediction of urban residential rents is of great importance for landlords, tenants, and investors. However, existing rents prediction models face challenges in meeting practical demands due to their limited perspectives and inadequate prediction performance. The existing individual prediction models often lack satisfactory accuracy, while ensemble learning models that combine multiple individual models to improve prediction results often overlook the impact of spatial heterogeneity on residential rents. To address these issues, this paper proposes a novel prediction model called GERPM, which stands for Geographically Weighted Stacking Ensemble Learning-Based Urban Residential Rents Prediction Model. GERPM comprehensively analyzes the influencing factors of residential rents from multiple perspectives and leverages a geographically weighted stacking ensemble learning approach. The model combines multiple machine learning and deep learning models, optimizes parameters to achieve optimal predictions, and incorporates the geographically weighted regression (GWR) model to consider spatial heterogeneity. By combining the strengths of deep learning and machine learning models and taking into account geographical factors, GERPM aims to improve prediction accuracy and provide robust predictions for urban residential rents. The model is evaluated using housing data from Nanjing, a major city in China, and compared with representative individual prediction models, the equal weight combination model, and the ensemble learning model. The experimental results demonstrate that GERPM outperforms other models in terms of prediction performance. Furthermore, the model’s effectiveness and robustness are validated by applying it to other major cities in China, such as Shanghai and Hangzhou. Overall, GERPM shows promising potential in accurately predicting urban residential rents and contributing to the advancement of the rental market.
Visfatin and Subclinical Atherosclerosis in Type 2 Diabetes: Impact of Cardiovascular Drugs
Authors: Kärberg Kati , Forbes Alastair , Lember Margus
Published: July 2023

Background and Objectives: The role of adipokines in the development of atherosclerosis in type 2 diabetes (T2DM) has not yet been fully elucidated. The effects of drugs on adipokine concentrations have only been evaluated in very few studies, although they may be of clinical importance. This study aimed to assess whether the concentrations of circulating adipokines could predict subclinical atherosclerosis in patients with T2DM, as well as their interactions with commonly used cardiovascular drugs. Materials and Methods: Our population-based cross-sectional multicentric study included 216 participants with T2DM but without previously diagnosed atherosclerosis. The carotid artery intima–media thickness (IMT), plaque and ankle–brachial index (ABI) metrics were measured. Resistin, visfatin, retinol-binding protein 4, high molecular weight adiponectin and leptin levels were evaluated using Luminex’s xMAP technology. Results: Visfatin and resistin concentrations correlated positively with IMT (p = 0.002 and p = 0.009, respectively). The correlation of visfatin to IMT ≥ 1.0 mm was significant in males (p < 0.001). Visfatin had a positive correlation with IMT ≥ 1.0 mm or plaque (p = 0.008) but resistin only correlated with plaque (p = 0.049). Visfatin predicted IMT ≥ 1.0 mm or plaque in patients on β-blocker monotherapy (p = 0.031). Visfatin lost its ability to predict subclinical atherosclerosis in patients taking angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, calcium channel blockers or statins. After adjustments for risk factors for atherosclerosis and cardiovascular drugs, visfatin maintained an independent association with mean IMT (p = 0.003), IMT ≥ 1.0 mm or plaque (p = 0.005) and ABI ≤ 0.9 (p = 0.029). Conclusions: Visfatin could be used as a marker of subclinical atherosclerosis in patients with T2DM, especially in males. The assessment of visfatin concentration could aid in identifying individuals who could benefit from implementing preventive measures against atherosclerosis.
Effects of the Applied Potential on the Performance of Polysulfone Membranes Functionalized with Sulfonated Polyether Ether Ketone Polymers
Authors: Fionah Abelline , McLarney Kate , Judd Aviana , Escobar Isabel C.
Published: July 2023

The global water crisis growth has led to a tremendous increase in membrane technology research. Membranes are favored over many other technologies for water treatment because, in principle, they require no chemical additives and can be used isothermally at low temperatures. Membranes that can reject contaminants and salts, produce adequate permeate flux values, and require minimal cleaning are highly demanded. However, most synthesized membranes on the market have associated problems, such as membrane fouling; inverse relationships between flux and solute rejection; and the high cost of synthesis, operation, and maintenance. Therefore, there is a continuied need to produce membranes with properties that make them able to sustain flux and selectivity over time. This research study focused on increasing the surface charge and hydrophilicity of polysulfone (PSf) membranes by incorporating sulfonate-functionalized poly-ether-ether-ketone (SPEEK) into PSf/N-Methyl-2-pyrrolidone (PSf/NMP) membranes. The sulfonation of the PEEK provided a net increase in negative charge on the surface of the membranes that enabled charge repulsion to take place, thus increasing the rejection of ions. In this project, the effect of the applied potential on the performance of SPEEK: PSf/NMP membranes was evaluated. The characterization of the as-synthesized membranes was carried out using the surface’s structure and morphology, contact angle, and zeta potential. Furthermore, a voltage of 1.5 V was applied to the membranes in the presence of various salts (sodium chloride, calcium chloride, and potassium chloride salts) to evaluate the effects of the applied potential on solute rejection. It was found that both the permeability and the selectivity of the membranes increased when the voltage was applied. The obtained results indicate that incorporating SPEEK into PSf/NMP membranes increased the hydrophilicity of the membranes, and under the applied voltage, the incorporation allowed it to function as an electrodialysis process that is capable of removing ions from water bodies by utilizing the charge repulsion of ions.
Impact of SWMM Fouling and Position on the Performance of SWRO Systems in Operating Conditions of Minimum SEC
Authors: Ruiz-García Alejandro , Al-Obaidi Mudhar A. , Nuez Ignacio , Mujtaba Iqbal M.
Published: July 2023

Due to water stress in the world in general desalination technologies are becoming increasingly important. Among the available technologies, reverse osmosis (RO) is the most widespread due to its reliability and efficiency compared to other technologies. The main weakness of RO is the loss of performance due to membrane fouling, which usually affects the water permeability coefficient (A), causing it to decrease. In RO desalination plants, fouling does not affect all spiral wound membrane modules (SWMMs) in the pressure vessels (PVs) in the same way. This will depend on the type of fouling and the position of the SWMM inside the PV. In this study, the impact of A and the position of the SWMM on the performance of the RO system is analyzed. For this purpose, decrements of up to 50% have been assumed for the seven SWMMs in series considering nine commercial SWMM models. The operating point analyzed is that which minimizes the specific energy consumption (SEC), a point obtained in a previous work carried out by the authors. The results show how the impact of A on the SWMM in the first position is more significant than the impact on modules that are in another position for the nine SWRO models studied. A drop of 50% in the coefficient A of the first element produces a permeate loss in the pressure pipe between 0.67 and 1.35 m3 d−1. Furthermore, it was observed that the models with the lowest coefficient A exhibited the highest performance losses in terms of permeate production when A was decreased.
Aqueous Extracts of Fermented Macrofungi Cultivated in Oilseed Cakes as a Carbon Source for Probiotic Bacteria and Potential Antibacterial Activity
Authors: Cunha Joice Raísa Barbosa , Wischral Daiana , Peláez Rubén Darío Romero , De Oliveira Magalhães Pérola , Guimarães Marina Borges , de Jesus Maria Aparecida , Sales-Campos Ceci , Mendes Thais Demarchi , Dias Eustáquio Souza , Mendonça Simone , de Siqueira Félix Gonçalves
Published: July 2023

Plant biomass colonized by macrofungi can contain molecules with bioactive properties with applications to human/animal health. This work aimed to verify antibacterial activities from aqueous extracts from oil seed cakes of Jatropha curcas (JSC) and cottonseed (CSC), fermented by macrofungi for probiotic bacteria cultivation. Coriolopsis sp., Tyromyces sp., Panus lecomtei, and Pleurotus pulmonarius were cultivated in solid and submerged media. The aqueous extract of unfermented JSC was more efficient than glucose for the growth of all probiotic bacteria. Extracts from four macrofungi fermented in CSC favored Lactobacillus acidophilus growth. In solid fermentation, macrofungi extracts cultivated in JSC favored Bifidobacterium lactis growth. All fungi extracts showed more significant growth than carbohydrates among the four probiotic bacteria evaluated. Regarding antimicrobial activities, no fungal extract or bacterial supernatant showed a more significant inhibition halo for enteropathogenic bacteria than ampicillin (control). Extracts from P. lecomtei and Coriolopsis sp. in CSC showed inhibition halos for Salmonella enterica. Supernatants from L. acidophilus, B. lactis, and Lactobacillus rhamnosus resulted in more significant inhibition of Staphylococcus aureus than the control, which indicates possible antimicrobial activity. Unfermented JSC supernatant showed better results for bacterial growth, while supernatants and aqueous extracts from CSC fermentation can be used for probiotic bacteria culture.
Integrating Omics Data in Genome-Scale Metabolic Modeling: A Methodological Perspective for Precision Medicine
Authors: Sen Partho , Orešič Matej
Published: July 2023

Recent advancements in omics technologies have generated a wealth of biological data. Integrating these data within mathematical models is essential to fully leverage their potential. Genome-scale metabolic models (GEMs) provide a robust framework for studying complex biological systems. GEMs have significantly contributed to our understanding of human metabolism, including the intrinsic relationship between the gut microbiome and the host metabolism. In this review, we highlight the contributions of GEMs and discuss the critical challenges that must be overcome to ensure their reproducibility and enhance their prediction accuracy, particularly in the context of precision medicine. We also explore the role of machine learning in addressing these challenges within GEMs. The integration of omics data with GEMs has the potential to lead to new insights, and to advance our understanding of molecular mechanisms in human health and disease.