bluuebunny/crossref_metadata_2025 huggingface dataset:
Implementation of a digital health curriculum for health-care students
Authors: Yang Karoliina X. , Rosner Benjamin I. , Chan Steven R. , Brindis Ralph G. , Lee Tiffany M. , Khanna Raman R. , Auerbach Andrew D.
Published: September 2022

Introduction:

Digital health software technologies (DHSTs) have the potential to shift models of care delivery and improve patient outcomes. Health-care students lack training to prepare them for the growing breadth and depth of DHSTs that they will need to identify, assess, and use in their future clinical careers. The implementation of this pilot digital health curriculum aimed to provide health-care trainees skills to identify, assess, and use DHSTs in their future clinical careers.

Materials and Methods:

From June to August of 2021, the authors implemented a 10 weeks pilot educational internship in partnership with the Accelerated Digital Clinical Ecosystem (ADviCE), a multi-institutional collaborative created by physicians within University of California, San Francisco Health Informatics. Interns completed a customized digital health didactic program developed by program faculty, including a speaker series with clinical informaticists in the field, journal club discussions, and intern-led presentations. In addition, interns were given real-world educational opportunities to directly interact with DHST vendors in the process of creating a DHST registry. Interns also completed a postcourse survey to procure feedback about the pilot program’s strengths and weaknesses.

Results:

Interns learned from a didactic educational curriculum that included more than 10 h of live lectures, 3 supplemental readings, and structured interactions with 74 DHST vendors. Based on a survey to assess interns’ satisfaction with the internship, interns ranked the expert speaker series the highest with an average standard deviation ranking on a 5-point Likert scale of 4.6 (0.57) and journal club discussions the lowest with a ranking of 4.31 (0.96). Interns also gave feedback on recommending the internship to future students with a ranking of 4.6 (0.65).

Conclusion:

This first internship led to the positively favored and successful execution of a remote educational experience exploring digital health in medicine, while also giving interns direct interaction with a broad array of digital health companies.
A rehabilitation comparison of thoracoscopic and robotic lobectomy
Authors: Mo Xia , Shen Lei , Wang Min , Yang Jiahao
Published: September 2022

Objective:

This study aimed to compare rehabilitation after lobectomy performed with a Da Vinci robot versus thoracoscopy.

Materials and Methods:

Patients who underwent lobectomy at the Changzhou First People’s Hospital from November 2020 to May 2021 were analyzed retrospectively, including 182 patients in the Da Vinci robot group and 280 patients in the thoracoscopy group. Postoperative hospital stay and postoperative pain were compared between groups.

Results:

The hospitalization cost of the Da Vinci robot group was $ 10874.06 ± 1757.07, which was higher than that of the thoracoscopy group ($ 7500.96 ± 1704.83). The postoperative hospital stay was significantly shorter in the Da Vinci robot group (4.74 ± 2.104 days) than that in the thoracoscopy group (5.55 ± 2.669 days; t = −3.664, P < 0.001). No significant differences between groups were observed in postoperative intensive care unit admission time and postoperative chest tube indwelling time. The proportion of patients with no pain 2 h after the operation was significantly higher in the Da Vinci robot group than in the thoracoscopy group (26.9% vs. 11.8%; χ
2 = 17.639, P < 0.001). The proportion of patients with no pain during the first activity was significantly higher in the Da Vinci robot group than in the thoracoscopy group (54.9% vs. 39.6%; χ
2 = 12.109, P = 0.004).

Conclusion:

The total cost of Da Vinci robotic surgery was higher than that of thoracoscopy for lobectomy, but the postoperative recovery was better, and the pain was less severe.
Serum levels of interleukin-6 and Vitamin D at the onset of multiple sclerosis and neuromyelitis optica
Authors: Ashtari Fereshteh , Madanian Reyhanehsadat , Zarkesh Sayyed Hamid , Ghalamkari Arshia
Published: September 2022

Background:

Interleukin-6 (IL-6) is an important mediator in the acute phase of inflammatory diseases such as neuromyelitis optica (NMO) and multiple sclerosis (MS). The level of IL-6 is higher in cerebrospinal fluid and serum of NMO patients compare to MS. Vitamin D has a regulatory effect on IL-6, so it may have a negative correlation with IL-6 in the acute phase of these diseases. This study was performed to evaluate the serum levels of IL-6 and Vitamin D in NMO and MS patients at the onset of disease to find differences that may help in early diagnosis.

Materials and Methods:

This case–control study was done on patients with the first episode of optic neuritis, transverse myelitis, and area postrema syndrome who were referred to Kashani MS Center in Isfahan, Iran, between January 2018 and January 2020. The serum levels of Vitamin D and IL-6 were assessed using enzyme-linked immunosorbent assay in blood sample taken at the time of first presentation in patients who had a definitive diagnosis of NMO and MS during subsequent workup.

Results:

During a 2-year follow-up, definitive diagnosis of NMO was given in 25 cases, and they were compared with 25 cases that were randomly selected from patients with definite MS. Nineteen patients in the NMO group and 21 patients in the MS group were female. The mean age of patients in the NMO and MS groups was 29.64 ± 1.47 and 30.20 ± 1.42, respectively (P = 0.46). The mean of serum level of Vitamin D was 24.88 ± 15.2 in NMO patients and 21.56 ± 18.7 in MS patients without significant difference (P = 0.48). The mean of IL-6 was 30.1 ± 22.62 in the NMO group and 23.35 ± 18.8 in the MS group without significant difference (P = 0.28). The serum levels of Vitamin D were insufficient in both groups. No correlation between Vitamin D and IL-6 levels was found in our study (P > 0.05).

Conclusion:

Our results showed that serum IL-6 levels were higher at the onset of NMO disease compared with MS. The serum levels of Vitamin D were low in both groups and there was no association between serum levels of Vitamin D and IL-6 in either group. Future studies with large sample size are needed to confirm these findings.
Constructing a novel competing Endogenous RNAs network based on NR3C1 and X-linked inhibitor of apoptosis protein genes reveals potential prognostic biomarkers in colorectal cancer
Authors: Abdolvand Mohammad , Sadeghi Minoosh , Emami Mohammad Hassan , Fahim Alireza , Rahimi Hojjatolah , Amjadi Elham , Baghaei Abdolmehdi , Abdolvand Shirin , Maghool Fatemeh , Feizbakhshan Sara , Salmanizadeh Sharareh , Heidari Ehsan , Chehelgerdi Mohammad , Khodadoostan Mahsa , Ebrahim Maryam , Beni Faeze Ahmadi , Kazemi Mohammad , Hemati Simin , Khosravian Farinaz , Rahimi Hassan , Samadian Alireza , Salehi Mansoor
Published: September 2022

Background:

Long noncoding RNAs (lncRNAs) have been recognized as the main modulatory molecules in various cancers and perform as competing endogenous RNAs (ceRNAs). The nuclear hormone receptor superfamily of ligand-activated transcription factors (NR3C1) regulates numerous proliferative and metabolic processes such as tumorigenesis and metabolic diseases. Furthermore, X-linked inhibitor of apoptosis protein (XIAP) belongs to a family of the inhibitors of apoptosis proteins, is located downstream of the glucocorticoid receptor (GR or NR3C1) pathway, and cooperates with GR to suppress apoptosis. However, the underlying mechanisms of NR3C1 and XIAP in colorectal cancer (CRC) remain mainly unclear. This research aims to clarify the potential RNA biomarkers and to construct a novel ceRNA network in CRC.

Materials and Methods:

Multistep bioinformatics methods such as Lnc2cancer and miRDB databases were applied to identify candidate lncRNAs and miRNAs. The interaction energy between lncRNAs, NR3C1, and XIAP genes was analyzed by the LncRRIsearch database. Plus, microRNAs and lncRNA were evaluated via the Diana tools database to select microRNAs with the most binding scores. Quantitative reverse transcription–polymerase chain reaction (QRT-PCR) was applied to verify RNA molecules’ expression levels and their association with the clinicopathological factors in 30 CRC tissues compared to 30 adjacent tissues.

Results:

QRT-PCR showed upregulation of KCNQ1OT1, NR3C1, and XIAP and downregulation of miR-421. The ceRNA network was constructed with 17 lncRNAs, 2 mRNAs, and 42 miRNAs. Thus, we explained the potential interactions between KCNQ1OT1 and miR-421 with NR3C1 and XIAP genes.

Conclusion:

Our study represents potential prognostic biomarkers and a new ceRNA network for further study in CRC.
Benthic Foraminifera of the Upper Jurassic Platform Carbonate Sequence in the Aydincik (Içel) Area, Central Taurides, S Turkey
Authors:   Mersin Universitesi Jeoloji Mühendisligÿ i Bulumü, Tasli Kemal
Published: September 2022

The Upper Jurassic sequence of the Aydincik (Içel) area consists of platform limestones which were deposited in a subtidal, restricted lagoon environment. Stratigraphic distribution of benthic foraminifera and calcareous algae, examined in thin-sections, is shown in a range-chart. The microfossil assemblage indicates the Salpingoporella sellii subzone of the Kurnubia palastiniensis cenozone, corresponding approximately to the lower part of the Malm. Some benthic foraminifera with considerable stratigraphic value within the Mesozoic Tethys are described. Among the benthic foraminifera, taxa of the family Pfenderinidae, especially the subfamily Kurnubiinae, are dominant and frequent throughout the sequence. The planispirally coiled taxa are represented by the families Nautiloculinidae, Charentiidae and Cyclamminidae (subfamily Bucciccrenatinae).
Desinformación y vacunas en redes
Authors: Noguera Vivo José Manuel , Grandío-Pérez María del Mar , Villar-Rodríguez Guillermo , Martín Alejandro , Camacho David
Published: September 2022

Introducción: Los bulos antivacunas son un tipo de desinformación sanitaria con gran peligro, dados sus efectos tangibles en la sociedad. Existen investigaciones relevantes sobre tipología de bulos, discursos negacionistas en redes o popularidad de las vacunas, pero este estudio aporta una visión complementaria y pionera, centrada en el discurso antivacunas de COVID-19 en Twitter desde la perspectiva del comportamiento de las cuentas que difunden desinformación. Metodología: A partir del método de FacTeR-Check, compuesto por cinco fases y una primera muestra basada en un centenar de bulos (diciembre de 2020 y septiembre de 2021) se descargaron 220.246 tuits, filtrados para trabajar con inteligencia artificial y técnicas de inferencia de lenguaje natural (NLI) sobre una segunda muestra de más de 36.000 tuits (N=36.292). Resultados: Los resultados ofrecen predominancias de algunos tipos de producción de desinformación, así como la eficacia de crear contenido original falso para agrupar seguidores o la identificación de un periodo (2013-2020) de más dominación de los usuarios que apoyan bulos, frente a los que los niegan. Discusión: El artículo muestra cómo la tipología o morfología de las cuentas puede ser un factor predictivo acerca del comportamiento de dichos usuarios respecto al caso particular de los bulos analizados. Conclusiones: Se ofrecen patrones de comportamiento del discurso antivacunas en Twitter, que pueden ayudar a gestionar futuros fenómenos similares. Dado el significativo tamaño de la muestra y de las técnicas empleadas, se puede concluir que este trabajo establece una base sólida para otros estudios comparativos sobre desinformación y salud en redes sociales.
Равномерно и локально выпуклые несимметричные пространства
Authors: Tsar'kov Igor' Germanovich
Published: September 2022

Для равномерно выпуклых несимметричных пространств рассматриваются вопросы о непустых пересечениях вложенной системы выпуклых ограниченных замкнутых множеств. Изучаются вопросы о плотности множеств точек существования и аппроксимативной единственности в этих пространствах для случая непустых замкнутых подмножеств. А также изучается проблема существования и устойчивости чебышeвских центров и связь понятия $\gamma$-солнца со свойством солнечности и существования. Изучаются достаточные условия радиальной $\delta$-солнечности.
Библиография: 27 названий.
Coğrafi Bilgi Sistemleri Tabanlı Çankırı Merkez İlçesinin Taşkın Duyarlılık Analizi
Authors: DUMAN Neşe , İRCAN Mustafa Recep
Published: September 2022

Yeryüzünde beşerî kaynaklı etkilerin artmasıyla sel ve taşkın gibi doğa olayıları, afet boyutuna ulaşarak çok sayıda can ve mal kayıplarının yaşanmasına neden olmaktadır. Bu durum özellikle insan kaynaklı iklim değişikliği süreciyle yaşanan/yaşanacak afetlerin boyutunu da arttıracaktır. Bu çalışmada Çankırı merkez ilçesinde taşkın riskinin yüksek olduğu alanların tespit edilmesi amaçlanmıştır. Bu amaç dahilinde Çok Kriterli Karar Verme Yöntemi kullanılarak matris değerleri hesaplanan coğrafi kriterler, ArcGIS yazılımında Weighted Sum (Ağırlıklı Toplam) yöntemiyle analiz edilmiştir. Elde edilen bulgular, haritalar, uydu görüntüleri ve arazi fotoğrafları yardımıyla açıklanarak tartışılıp yorumlanmıştır. Bulgulara göre, Çankırı merkez ilçesindeki akarsuya yakın düzlüklerden %1,8 (25,9 km²)’inin çok yüksek; %16,6 (239,3 km²)’sının ise yüksek taşkın riski taşıdığı görülmektedir. Özellikle taşkın riskinin yoğun olduğu alanlardan birinin Çankırı ilçe merkezi olduğu tespit edilmiştir. Başta Çankırı ilçe merkezi olmak üzere akarsu yatak kapasitesinin bozulması, çekik yatağı seviyesinde planlamalar yapılması gibi nedenler ile gelişen meteorolojik ve hidrolojik etkenler sonucunda, akarsuyun çekik yatağından çıkarak taşkın yatağında çok sayıda can ve mal kaybına neden olacağı düşünülmektedir. Araştırma sahasında taşkın riskinin yüksek olduğu alanlara yerleşmelerin kurulması, ani ve yüksek yağışlarla yaşanan durumu bir doğa olayı olmaktan çıkararak afet boyutuna dönüşmesine neden olacaktır.
SELECTION OF THE RANGE OF GEAR RATIOS OF THE MECHANICAL PART OF THE ELECTROMECHANICAL POWER TRAIN OF THE TRACTOR
Authors:   Belarusian National Technical University, ZHDANOVICH Cheslav I. , KALININ Nikita V. ,   Joint Institute of Mechanical Engineering of the NAS of Belarus
Published: September 2022

A method has been developed for selecting the gear ratio of the mechanical part of the power train (MPPT) to work on agricultural operations of a tractor of the 5th drawbar class equipped with an electromechanical power train with a traction induction electric motor (TIM). It is assumed that there are two gears: the high one (n-th) for operation in transport mode and the low one (n–1st) for operation in operational and technological modes. The gear ratio MPPT uМЧТ,n, corresponding to the nth gear, is determined from the condition of ensuring the required maximum velocity of the tractor. The gear ratio of the MPPT uМЧТ(n–1), corresponding to the n–1st gear, must be in the range from the uМЧТ(n–1),р, at which the minimum plowing velocity will be provided at the nominal value of the voltage frequency supplied to the TIM, to the uМЧТ(n–1),max, determined by from the condition of providing the maximum possible velocity range of the tractor with only the n-th gear without overlapping its n–1st gear. A formula is also proposed for determining the value of the uМЧТ(n–1),v, at which the tractor can operate with the maximum velocity permissible for a given agricultural operation. If uМЧТ(n–1),v < uМЧТ(n–1) < uМЧТ(n–1),р, then the entire velocity range for a given agricultural operation will be provided when working in the n–1st gear. In order to determine the uМЧТ(n–1) with the best traction efficiency, it is proposed to carry out tractor traction calculation for the values of uМЧТ(n–1) taken in the range from uМЧТ(n–1),р to uМЧТ(n–1),max with a certain step. After that, for the selected value uМЧТ(n–1), it is necessary to calculate the TIM losses during tractor operation in the entire velocity range provided by the n–1st gear. If the thermal mode of the TIM is not performed when the tractor is moving at low velocities in the n–1st gear, then it is necessary either to take a larger value of the uМЧТ(n–1) at which it is performed, or in case of a small excess of the permissible power losses of the TIM, do not increase the uМЧТ(n–1), but take this into account when designing the TIM cooling system.
ON THE CHOICE OF MODERN STRUCTURAL METAL MATERIAL FOR HIGH-DUTY MECHANICAL SYSTEMS. PART 1
Authors:   Belarusian State University of Transport, SOSNOVSKIY Leonid A.
Published: September 2022

It is shown that when solving the problems of assurance of quality, reliability, competitiveness of high-duty mechanical systems, metal and a complex of its mechanical and service properties are of fundamental importance. Steel cast iron MONICA (Mo–Ni–Cu) (patent BY, no. 15617) exhibits an unconventional and unique ability to lose brittleness (increase viscosity) with increasing strength. In terms of service properties, it is not inferior to alloyed heat-strengthened steels. This makes it possible to recommend it for the manufacture of various highly loaded parts and assemblies of modern technology. The article provides several examples of the effective use of MONICA for the manufacture of cast knives for cutting and chopping devices of forage harvesters (Hi-Tech), large-sized gear wheels with a diameter of 500 mm for final drives of agricultural combines (know-how), as well as experimental cast rails for railway transport (Hi-Tech). A complex of laboratory and full-scale tests has convincingly proved that one brand of a new structural material fully provides the required operational reliability of many and different tribo-fatigue systems, the performance of which is determined by many criteria (fatigue, wear, friction, crack resistance) under the action of high repetitive variables and shock-cyclic loads. This determines the unconditional efficiency and competitiveness of critical mechanical systems (tribo-fatigue systems) for modern machines and equipment.
The history of life in the foundation of xocolátl
Authors: Ayala Ricardo Ortiz , Mota María del Pilar Scott , Solís Alejandra Urbiola
Published: September 2022

The business project " Xocolatl , Drink of the Gods" of the SME sector in Mexico, is a success story, whose formal management is currently adequate, but there is something deeper that has positioned it in the place it is now. Beyond the measurement of what is visible, the quantitative and the numbers, knowing how it was founded and what led the company to remain in the market, unlike other entrepreneurs who saw the need to closing in the first years of your business will allow you to analyze the intrinsic and cultural factors that are key to your success. This study deals with the existence of the company, addressing its life history, the circumstances that influenced its foundation and permanence, which are very particular and could not be known more than through the narrative of its founder.
Analisa Laporan Penyelenggaraan Pemerintah Daerah di Masa Pandemi Covid-19
Authors: Virdanti Citra Ramadhani Ayu Nur , Triputro R. Widodo
Published: September 2022

The preparation of the LPPD is a form of accountability for the administration of local government in Sleman Regency for one year. This is mandatory because it has been stated in Law Number 23 of 2014 concerning Regional Government. In addition, the results of the collection of LPPDs to the Central Government will be used as a reference for policy-making on regional problems as well as an early detection tool for national policy problems.
A Survey, Investigation and Design (Sid) of Agricultural Land Explanation and Opening of Kaliki Village , Kurik District as Efforts to Improve the Economy for Native Papuans
Authors:   Department of Architecture, Musamus University Merauke, Syanjayanta Biatma
Published: September 2022

With the stipulation of Merauke Regency as one of the national food barns, Merauke Regency continues to improve, especially to increase the productivity of lowland rice. This is also expected to have an impact on increasing farmers' income, especially Papuan natives (OAP) which in turn improves the welfare of the OAP community in Merauke Regency. The aims of this study are (1) to conduct an Investigational Survey of Paddy Fields in Kaliki village, Kurik district, Merauke district, by observing and measuring the field, so that it can be a technical reference in the implementation of new rice fields. (2) Designing rice field printing in Kaliki village, Kurik district, Merauke district, based on the norms of technical standards and criteria for rice field printing. (3) Plan and determine the area of ​​land that can be used as rice field farming land that is adjusted to the CPCL OAP in Kaliki village. The results of this study are: (1) Based on the results of the analysis of geological maps, topographic maps, demographic surveys (CPCL) as well as customs and culture that have been carried out in the work area, the results are: the location of paddy fields in the work area shows alluvial soil types with characteristics soil. (2) In connection with the very thick existing local wisdom, which is closely related to customary laws, in terms of planning for land clearing in Kaliki village, a traditional approach will be needed, so as to obtain solutions that can benefit all parties, especially the village community. kaliki. (3) The area at the location of the SID rice field printing work in the Kaliki village which is adjusted to the CPCL data and the needs of the village is 127 Ha.
Hull Form Optimization of Fishing Vessels by Adoption of Stern Wedge and Bilge Keel
Authors:   Assistant Professor, Kunjali Marakkar School of Marine Engineering, CUSAT, C P Najdan Waris
Published: September 2022

The most recent ships incorporate a number of significant design enhancements to improve the vessel’s seaworthiness. Bulbous bow, bilge keel, stern wedge, stern tunnel, spray rails, and others are examples. A stern wedge is a small modification of the buttock lines aft of station 19 1/2. The use of this hull design feature on small high-speed planning craft for the purpose of improved powering performance is an accepted naval architectural practice. However, its use on fishing vessels is uncommon. A bilge keel is a marine gear that reduces the tendency for a ship to roll. Hull shape modifications such as bilge keel can potentially increase safety by reducing roll motions. These enhancements have not been adopted or evaluated on fishing vessels, despite the fact that they have been employed on seagoing ships. The installation of bilge keels on fishing vessels was found to have a significant influence on the roll motion of the vessels, boosting their safety and efficiency. When compared to normal trawlers, the installation of bilge keels increased roll period by at least 40% and reduced roll amplitude by 16%.
The Impact of Open Sky on Airlines Theoretical Study: Case of Tunisia
Authors:   Research structure: VPNC LAB, Nidham GHAZOUANI
Published: September 2022

At the level of this article to understand the potential economic effects of an “open skies” agreement, in particular on competition, prices and airline profits. We will try in a first part to determine if consumers will benefit from price reductions following the entry into force of an Open Sky agreement, we will also try to see the effects of “open sky” agreements on competition.
The Effect of Capital Structure and Liquidity on Investment Decisions with Profitability as Intervening Variable in Manufacturing Companies Listed on Bei
Authors:   Universitas Mahasaraswati Denpasar
Published: September 2022

This study aims to examine the effect of capital structure and liquidity on investment decisions with profitability as an intervening variable. The method used in this sampling is purposive sampling. The sample in this study were 63 manufacturing companies listed on the Indonesia Stock Exchange for the 2018-2020 period. The data analysis technique used in this research is the path analysis technique and the Sobel test. The results showed that capital structure had a negative and significant effect on profitability and liquidity had no effect on profitability, then capital structure, liquidity and profitability had a positive and significant effect on investment decisions.
The Uniqueness of Ho Chi Minh in political communication
Authors:   VNU University of Social Sciences and Humanities, No. 336 Nguyen Trai Street, Thanh Xuan district, Hanoi, Vietnam.
Published: September 2022

Ho Chi Minh was great leader who wholeheartedly devoted himself to the country and the happiness of the people. His lessons and ideas are timeless, as evidenced by the fact that they have been studied continuously by scholars from all over the world. The political communication is just one component of that. Despite the fact that under the presidency of Ho Chi Minh, this concept was most likely still quite vague, the methods that Ho Chi Minh utilized in political communication demonstrated a significant amount of progress. In the following article, we will concentrate on the primary strategies that President Ho Chi Minh utilized in the course of his political communication endeavors. The content of this article is broken up into three sections: the first section introduces some fundamental concepts and rationale; the second part analyzes President Ho Chi Minh's style of political communication; and the third and final section provides some comments and evaluations.
Use of Data Driven Index for Profitability Measure of Indian Public Sector Banks
Authors:   Assistant Professor, Memari College, West Bengal, India
Published: September 2022

A strong and sound financial system is a necessary precondition for accelerated growth of an economy. In a country like India, the banking system is the heart of the financial system since they infuse money in the system resulting in additional purchasing power. The rate of financial intermediation, capital formation and rate of economic growth are inextricably linked. Higher the rate of financial intermediation, higher the rate of capital formation and higher will be the economic growth rate and vice-versa. An organized, efficient, well-planned and viable banking system is, therefore, a demanded concomitant for development of a country. But all these requirements can be fulfilled while banks are sustaining a healthy bottom-line. In this backdrop, the present paper strives to suggest a data driven index to assess the profitability performance of Indian PSBs during the study period.
Some Challenges in Digital Transformation in Vietnam Now
Authors:   University of Prince Edward Island, Canada
Published: September 2022

Journalism is a field in society that will have to undergo digital transformation according to the general development trend, and even develop into a digital media economy. Digital transformation in journalism is not simply a mechanical release into the digital environment. Still, digital transformation is the processing of information obtained from the digital ecosystem, while also facing a number of difficulties such as human resources, finance, fake information, etc. The article focuses on presenting some key features of the current state of digital transformation in journalism, raising challenges in the digital transformation process in the journalism sector, and making some recommendations to transform the field of journalism more effectively in the near future.
Desenvolvimento e caracterização físico-química e microestrutural de iogurtes
Authors:   , Gomes Elisângela Ramieres
Published: September 2022

Produtos lácteos fermentados são amplamente consumidos em todo mundo devido as suas características sensoriais e nutricionais. Nos últimos anos houve um aumento da demanda por parte dos consumidores e também por órgãos governamentais para o desenvolvimento de produtos com menores teores de açúcares e gorduras. No entanto, é um desafio para a indústria de alimentos reduzir a gordura e açúcar de produtos fermentados como o iogurte, porque esses componentes influenciam no sabor, textura e viscosidade desses produtos. Portanto, o objetivo desse trabalho foi o desenvolvimento e caracterização de iogurtes (i) iogurtes adicionados de leitelho, com consequente redução de gordura; (ii) adição de fibras solúveis como substituto parcial do açúcar e (iii) adição de fibras solúveis em iogurte com alta proteína sem adição de gordura e sem açúcar. Foram realizadas análises de composição, acompanhamento da curva de fermentação, análise do perfil de textura, viscosidade aparente, capacidade de retenção de água, sinérese, distribuição do tamanho de partículas por difração à laser, microscopia eletrônica de varredura e tamanho médio dos poros dos diferentes géis formados. Como resultados pode-se destacar no artigo 1 o iogurte adicionado de 3,34% m·m -1 de leitelho (T3) no final da fermentação apresentou o menor tamanho de partícula quando comparado ao controle. A adição do leitelho promoveu à formação de uma microestrutura de rede menos compactada, apresentando menor elasticidade após 21 dias e menor dureza após 21 e 42 dias. No artigo 2, são apresentados os resultados que indicaram que as fibras solúveis (fibra de milho e polidextrose) empregadas no iogurte como substitutas parciais do açúcar, impactaram a microestrutura (tamanho dos poros) na e sinérese. A redução do nível de sacarose do iogurte de 9% para 0% levou a uma diminuição no tamanho dos poros da matriz e aumento da sinérese. Além disso, a adição de 2% de fibra de milho ou polidextrose no iogurte com redução de 50% do teor de sacarose quando comparado ao controle, aumentou o tamanho dos poros da matriz e diminuiu a sinérese. E no artigo 3, os dados mostraram que os iogurtes com alta proteína suplementados com 10% de fibra de milho 70%, fibra de milho 85% ou polidextrose proporcionaram uma maior queda de pH entre 3 e 6 horas de fermentação. Além disso, foi possível constatar que todos os iogurtes apresentaram uma alta capacidade de retenção de água. Os valores de d 90 diminuíram conforme aumentou as concentrações das fibras solúveis adicionadas. Os resultados obtidos dos diferentes estudos abrem perspectivas para produção de iogurtes contendo diferentes ingredientes como leitelho e as fibras solúveis. Palavras-chave: Iogurte. Textura. Microestrutura. Fibras solúveis.
Exploratory Study of Colloidal Properties of Black Soldier Fly (Hermetia illucens) Larvae Proteins Optimized by Sustainable Approches
Authors:   , Queiroz Lucas Sales
Published: September 2022

The black soldier fly larvae (BSFL), Hermetia illucens (Linnaeus), has been largely utilized for animal feed. Due to its interesting composition, BSFL has shown great potential to be further implemented in the human diet. Herein the main colloidal properties of BSFL protein extract were investigated, gelling, foaming and emulsifying ability were deeply studied. To improve knowledge on protein profile SDS-page electrophoresis, surface hydrophobicity, particle size and -potential Fourier-transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC) and other important methodologies were utilized. Interfacial rheology, shear and dilatational, were evaluated to understand the role of BSFLP when used as surfactant in oil-in-water emulsions. In addition, the physical and oxidative stability of fish oil-in-water (O/W) emulsions were investigated using BSFL protein extract as an emulsifier. Alternative treatment such as ohmic-heating and sonication were applied to verify their impact on protein extraction and functionality. Finally, a study evaluating protein hydrolysis on emulsifying property of BSFL was considered. As a result, the best foam stability was reached at 85 °C with 15 min of treatment. About the gelling behavior, 15 min of ultrasound was able to improve gel-like structure and the gel strength. Ultrasound treatment induced modifications on physicochemical and functional properties of BSFL protein. In emulsion systems, ohmic heated samples had the most interesting physical stability, however, the oxidative stability was not improved under the explored parameters. Considering the emulsions stabilized with hydrolysed protein samples (BSFLPH), it was concluded that, limited hydrolysis had the best physical stability considering the TSI value for 2 days. Both BSFLPH and BSFLP demonstrated surfactant properties as they decreased interfacial tension and created a viscoelastic protective film. Keywords: Black soldier fly. Techno-functionality. Protein extract. Sustainability.
Uio-67-5-Fu as A Drug Delivery Platform for 5-Fu
Authors:   Department of Inorganic Chemistry, Faculty of Chemistry & Petroleum Sciences Shahid Beheshti University (SBU), Tehran, Iran, Zarshenas Pourya
Published: September 2022

The drug delivery application of Porous metal–organic frameworks (MOFs) have been investigated due to their unique structures which are built of inorganic nodes and organic ligands. In present study, Uio-67-5-FU was successfully prepared by applied for delivery of 5-fluorouracil (5-FU). Using variety of analytical methods including FTIR, FESEM, EDS, and the prepared nanostructure was characterized. Results revealed the placement of the drug in zeolite is well done and also the in vitro loading and releasing studies, for 5-FU was evaluated. In addition, Based on the in vitro cytotoxicity results, Uio-67-5Fu was able to increase cytotoxicity compared to that of 5-Fu on HT-29 cancerous cells indicating the highlighted role of this drug delivery system.
Chronic Kidney Disease in Patients with Diabetes: Diabetic vs. Non-Diabetic Kidney Etiologies
Authors:   Department of Nephrology, The Second Affiliated Hospital of Nanchang University, China, Wang Qi , Xu Gaosi ,   Department of Nephrology, The Second Affiliated Hospital of Nanchang University, China
Published: September 2022

Diabetes mellitus is a growing burden on global healthcare. Although the definition of Diabetic Kidney Disease (DKD) is that the kidney disease due to type 1 or 2 diabetes, the clinical diagnosis of DKD remains controversial. The diagnosis of DKD is highly subjective, depending on the doctor’s judgment and experience. It is necessary to distinguish the non-diabetic kidney disease from DKD at an early time, however, it is also seems difficult and inefficient. Up to date, there is lack of the diagnostic flow diagram for the disease. In this mini-review, we for the first time focused to create a diagnostic workflow for the disease
Diabetic Cheiroarthropathy
Authors:   Consultant Radiologist at Med Ray International Radiology Centers, Alsmair Ali
Published: September 2022

A 54-year-old man with type 2 diabetes mellitus presented with limitation of movement, flexion deformity and stiff skin of both hands. The diagnosis was suspected clinically. Both wrists MRI were requested, however only the right wrist MRI was obtained for financial conditions
Post-Covid-19 Immunological Disorder: A Possible Pathological Entity in a 43 Year Old Man
Authors:   Clinical Hospital, Bucharest, Romania, Scarlat Gabriel , Stoian Marilena ,   University of Medicine and Pharmacy, Bucharest, Romania
Published: September 2022

Background: Post-COVID-19 systemic inflammatory syndrome is considered to be an aquired immunological disorder, which may develop in some individuals after the remission of infection with SARS-CoV-2 and defined by inflammatory clinical manifestations (fever, arthralgias, cutaneous and mucosal pallor, physical weakness) and modified biological parametres (normochromic normocytic anaemia, increased serum levels of C reactive protein and rheumatoid factor), with no proof of an infectious process, to which corticotherapy may be a suitable therapeutic strategy. Case Report: A 43 year old male was admited in the Department of Internal Medicine for high fever (39,4°C), moderate polyarthralgias and physical weakness, with a negative test result of SARS-CoV-2 RT-PCR. The patient had been previously diagnosed with a moderate-to-severe form of COVID-19, a month prior to the current admission. The patient also experienced transitory dry cough for a month, with no other relevant clinical abnormalities. Upon physical examination, cutaneous and scleral pallor was observed and lung auscultation revealed hardened vesicular murmur bilaterally. Blood analysis revealed normochromic normocytic anaemia and increased serum levels of rheumatoid factor and of C reactive protein, which suggested a nonspecific inflammatory syndrome. Although blood cultures and other microbiological tests were negative for an infectious process, a chest X-ray was performed, which detected the presence of a nodular formation in the superior left lung lobe. Several differential diagnoses were taken into consideration, including pulmonary sarcoidosis and granulomatosis with polyangiitis, both of which were excluded, clinically and biologically. A thoracic computed tomography (CT) was later performed, which revealed the presence of a tumoral nodule in the left lung, associated with multiple mediastinal and supraclavicular lymphadenopathies, indicative of lung cancer. However, lung cancer was also excluded upon the histopathological examination of paratracheal lymphnodes, which detected multiple areas of parenchymal necrosis surrounded by dense inflammatory infiltrates, formed predominantly by histiocytes. All of these findings resulted in the diagnosis of a post-COVID-19 rheumatoid syndrome, the only therapeutic strategy being the administration of high doses of intravenous and oral methylprednisolone, which improved the patient’s health. Conclusion: Post-COVID-19 immunological disturbances should be taken into consideration in patients who experience repetitive clinical and biological inflammatory manifestations after the remission of the infection with SARS-CoV-2, which may be improved through high dose corticosteroid therapy
Fgfr Gene Mutation and Pfeiffer Syndrome
Authors:   Department of Biochemistry, Damietta University, Egypt, Elbossaty Walaa Fikry
Published: September 2022

Pfeiffer syndrome is a genetic disease caused by a defect in the FGFR-1 or FGFR-2 genes. This syndrome affects the skeleton, whether it is a protrusion of the skull bone or problems in the limbs. Not only this, but also affects the eyes, leading to their protrusion, in addition to the possibility of hydrocephalus, and internal viscera imbalance. There are 3 types of the syndrome classified according to the clinical examination of the case, where the symptoms range from mild to severe, which requires surgical intervention. It is easy to diagnose the fetus early through ultrasound examination, which shows ossification in the bones of the skull and deformities of the fingers. The incidence of Pfeiffer syndrome is limited, as it affects one child in 100,000 cases. Genetic testing facilitates early diagnosis and thus helps in rapid treatment and prevention of deterioration of the condition.
A Narrative Review on Various Treatment Methods for Coronary Microvascular Disease
Authors:   Department of Medicine, California University of Science and Medicine, Colton, USA, J Reddy Akshay , P Iskandar Nicholas
Published: September 2022

This investigation allowed us to understand more about the relationship between Plavix and the treatment of coronary microvascular dysfunction. The capacity of Plavix to work in tandem with aspirin in a dual treatment approach to improve the anti-platelet therapeutic impact and to lessen platelet aggregation brought on by platelet receptor blockade is one of the drug’s many important advantages. The researchers found that the average reduction in risk of adverse cardiovascular events caused by Plavix much outweighed any potential systemic harm. Although it has been shown that the current standard of care significantly lowers harm among people with micro cardiovascular disease, more study is needed to ensure that this standard is enhanced. It may become more typical in the future to include patient groups in trials without requiring diabetes as a requirement. It is possible that the study results are biased since diabetes patients often have higher LDL cholesterol levels than the overall population. To confirm or deny this claim, more investigation is necessary.
Science Communication in India: Current Trends and Future Vision
Authors:   Associate Professor, Department of Communication & Media Technology, J.C. Bose University of Science and Technology, YMCA, Faridabad, Haryana, India, Malik Pawan Singh , Dhiman Bharat ,   Assistant Professor, Department of Communication & Media Technology, J.C. Bose University of Science and Technology, YMCA, Faridabad, Haryana, India
Published: September 2022

India has a rich scientific heritage. Scientific research in astronomy, medicine, mathematics, and material science has been carried out since ancient times. India is advancing technologically, and the need to disseminate scientific information to the non-scientific community is growing rapidly day-by-day. Over the last few years, India has experienced a large-scale proliferation of science communication activities through various programs initiated by the central government, state government, and NGOs. This article attempts to provide an overview of the growth and development of science communication in India. It also identifies India’s current trends and future vision of science communication
Research On the Current Situation of Autonomous Vehicle Industry in China
Authors:   The East Asian Trade Association, Yang Yanlu , Lee Kidong , Wang Yiyuan
Published: September 2022

Purpose – The purpose of this paper is exploring the challenges it faces in the development status of domestic autonomous vehicle, looks forward to its future, and hopes to promote the research and development in this field and provide reference for promoting the development of autonomous vehicle.
Design/Methodology/Approach – Through the theoretical research on the development status of autonomous driving industry and national policies.
Findings – This paper studies precision marketing and smart recommendation, creative advertising improves revenue structure, optimizing user experience, resolving copyright disputes.
Research Implications – Affected by the COVID-19, the automobile industry as a whole is in a depressed state, and the future market competition will become increasingly fierce. Since the outbreak of the new crown disease, unmanned distribution vehicles have played an active role in epidemic prevention in many cities. The automobile industry is bound to complete the transformation from traditional manufacturing to intelligent manufacturing.
Progress toward defining the molecular identities of neocortical neurons
Authors:   Medical University of Innsbruck, Institute for Neuroscience, Deleanu Roxana
Published: September 2022

"The neurons that make up the human cerebral cortex are responsible for a wide array of higher cognitive, social-emotional, sensory and motor functions. These very complex functions are supported by a rich diversity of excitatory and inhibitory neurons, each of which has its own developmental pathway, and is specifically assembled into highly complex cortical circuits with powerful computational capacities. Recent studies using single-cell transcriptomics, single-cell electrophysiological recordings, and morphological reconstruction have begun to reveal surprising levels of neuronal diversity in mammals, defined by distinctive transcriptomic signatures, morphological, and physiological phenotypes. While most of the available data rely on studies performed on mouse neocortex, several recent findings in the human neocortex point to both conserved molecular profiles, and human-specific differences. Herein, the main milestones in the classification of neocortical neurons are discussed, beginning with the “classical” combination of a few class-specific marker expression and cell morphologies, and progressing to their origin and recent multiplex profiling. While single-cell and single-nucleus RNA sequencing data provide a huge progress in neuronal taxonomy, the boundaries between subclasses can be defined and validated only in combination with morphological and electrophysiological features. "
Scientific Approaches to the Definition of Ethnо-Tourism Concept
Authors: Mukatova Rabiga , Mussina Kamshat , Rodríguez Maribel
Published: September 2022

The relevance of this study is due to the fact that at present ethno-tourism is one of the most promising and popular areas in the world tourism market. The main purpose of study is to review and compare tourism development theories in terms of the main drivers of ethnо-tourism development. This article examines the theory of the ethnо-tourism concept development, their definitions and distinctive elements, the relationship between this type of tourism and ethnicity and cultural heritage. The authors compared the concept of ethnо-tourism with cultural and ethnоgraphic tourism, then revealed a strong tie between these concepts. In addition, the study examined the primary and secondary importance of cultural tourism and ethnо-tourism for tourists.

A systematic literature review was conducted in June 2022 based on two databases - ISI Web of Science and Scopus, the selected results were analyzed according to common characteristics and attributes: geographical location; assessment methods used in the article. According to the analyzed scientific papers, it was revealed that ethno-tourism research is gaining popularity in Asian countries, and comprehensive research methods are widely used.

In addition, this study emphasized the need for collaboration of tourists and local residents in organizing ethnо-tourism activities and the benefits from developing ethnо-tourism in the region for representatives of the local community and the regional economy were discussed. The role of ethnо-tourism in the preservation and protection of the cultural heritage of local communities were emphasized. Furthermore, the functions and main resources for the development of ethnо-tourism were analyzed.