bluuebunny/crossref_metadata_2025 huggingface dataset:
FPGA-Based Optical Surface Inspection of Wind Turbine Rotor Blades Using Quantized Neural Networks
Authors: Giefer Lino Antoni , Staar Benjamin , Freitag Michael
Published: November 2020

Quantization of the weights and activations of a neural network is a way to drastically reduce necessary memory accesses and to replace arithmetic operations with bit-wise operations. This is especially beneficial for the implementation on field-programmable gate array (FPGA) technology that is particularly suitable for embedded systems due to its low power consumption. In this paper, we propose an in-situ defect detection system utilizing a quantized neural network implemented on an FPGA for an automated surface inspection of wind turbine rotor blades using unpiloted aerial vehicles (UAVs). Contrary to the usual approach of offline defect detection, our approach prevents major downtimes and hence expenses. To our best knowledge, our work is among the first to transfer neural networks with weight and activation quantization into a tangible application. We achieve promising results with our network trained on our dataset consisting of 8024 good and defected rotor blade patches. Compared to a conventional network using floating-point arithmetic, we show that the classification accuracy we achieve is only slightly reduced by approximately 0.6%. With this work, we present a basic system for in-situ defect detection with versatile usability.
Cooling Panel with Integrated PCM Layer: A Verified Simulation Study
Authors: Millers Renars , Korjakins Aleksandrs , Lešinskis Arturs , Borodinecs Anatolijs
Published: November 2020

The focus of this research paper is to develop a verified simulation model for a cooling panel with integrated phase-change materials (PCMs)—a stainless steel panel filled with PCM and integrated hydronic piping circuit. This solution is targeted for passive cooling of residential buildings in Baltic Sea region that experience overheating for most of the year due to highly insulated building envelopes and extensive glazing—a phenomena for nearly zero energy buildings (NZEBs). This approach aims to maintain comfortable indoor temperature all year round by passive means—free-cooling, adiabatic (evaporative) cooling or limited mechanical cooling. The simulations are performed with IDA ICE 4.8 and the measurements for simulation model verification are collected from a test chamber. The results show that reasonable agreement can be reached for simulated and experimentally measured data.
Study on the Pore and Fracture Connectivity Characteristics of Oil Shale Pyrolyzed by Superheated Steam
Authors: Huang Xudong , Yang Dong , Kang Zhiqin
Published: November 2020

The connectivity of the internal pores and fractures in oil shale is the critical factor in determining the success of the insitu pyrolysis of the oil shale with superheated steam. In this paper, using a self-developed superheated steam pyrolysis experimental system, oil shale samples were subjected to pyrolysis experiments at different steam temperatures. Then, the oil shale samples were scanned with high-precision micro-CT equipment to obtain the three-dimensional digital core of oil shale (DCOS). Based on the three-dimensional site percolation theory and renormalization group algorithm, the pore and fracture connectivity characteristics of the DCOSs were studied. The results show that when the steam temperature reached the pyrolysis temperature for oil shale, a series of pores was formed during the pyrolysis process. These pores gradually connected the adjacent fracture and subsequently formed a massive pore-fracture cluster. However, from room temperature to 555 °C, there were always parts with porosity less than 5% in the DCOSs perpendicular to the direction of the sedimentary bedding, forming the bottleneck of the seepage passage. This occurrence is the main reason that the permeability of the oil shale perpendicular to the direction of the sedimentary bedding is far lower than that parallel to the direction of the sedimentary bedding.
An Optimal Energy Optimization Strategy for Smart Grid Integrated with Renewable Energy Sources and Demand Response Programs
Authors: Ullah Kalim , Ali Sajjad , Khan Taimoor Ahmad , Khan Imran , Jan Sadaqat , Shah Ibrar Ali , Hafeez Ghulam
Published: November 2020

An energy optimization strategy is proposed to minimize operation cost and carbon emission with and without demand response programs (DRPs) in the smart grid (SG) integrated with renewable energy sources (RESs). To achieve optimized results, probability density function (PDF) is proposed to predict the behavior of wind and solar energy sources. To overcome uncertainty in power produced by wind and solar RESs, DRPs are proposed with the involvement of residential, commercial, and industrial consumers. In this model, to execute DRPs, we introduced incentive-based payment as price offered packages. Simulations are divided into three steps for optimization of operation cost and carbon emission: (i) solving optimization problem using multi-objective genetic algorithm (MOGA), (ii) optimization of operating cost and carbon emission without DRPs, and (iii) optimization of operating cost and carbon emission with DRPs. To endorse the applicability of the proposed optimization model based on MOGA, a smart sample grid is employed serving residential, commercial, and industrial consumers. In addition, the proposed optimization model based on MOGA is compared to the existing model based on multi-objective particle swarm optimization (MOPSO) algorithm in terms of operation cost and carbon emission. The proposed optimization model based on MOGA outperforms the existing model based on the MOPSO algorithm in terms of operation cost and carbon emission. Experimental results show that the operation cost and carbon emission are reduced by 24% and 28% through MOGA with and without the participation of DRPs, respectively.
Photovoltaic Concentration: Research and Development
Authors: El Himer Sarah , El Ayane Salima , El Yahyaoui Sara , Salvestrini Jean Paul , Ahaitouf Ali
Published: November 2020

Concentrator Photovoltaic (CPV) technology, by using efficient optical elements, small sizes and high efficiency multi-junction solar cells, can be seen as a bright energy source to produce more cost-effective electricity. The main and basic idea is to replace the use of expensive solar cells with less expensive optical elements made from different materials. This paper aims to give to the readers a rapid and concise overview of CPV and the main characteristics to be considered when designing a CPV system. It reviews the main optical configurations presented in the literature, their advantages and drawbacks, as well as the recent progress in the concentration ratio and the major performances achieved in the field. The paper considers the more recent works, their optical designs, as well as their optical and electrical performances. It also relates the major achievements on the industrial side with the major milestones in CPV developments.
Thermal and Energy Performance Assessment of the Prefab Electric Ondol System for Floor Heating in a Residential Building
Authors: Lee Wongeun , Lim Taesub , Kim Daeung Danny
Published: November 2020

In South Korea, radiant floor heating has been used from old housing to the recently constructed residential buildings, which is called “Ondol”. The Ondol system is generally a water-based system and it uses hot water as a heat medium provided by boilers fueled by natural gas. With great effort to reduce greenhouse gas emissions, electric Ondol panels have been increasingly applied to the recent residential buildings for floor heating. While the prefab electric Ondol panels were developed with the demand for dry construction method, the information about the prefab electric Ondol system is not sufficient. For the present study, the thermal performance of the prefab electric Ondol panels was investigated through field measurement. In addition, the heating energy and economic performance of the electric panel were compared with the conventional Ondol system. As a result, a significant surface temperature difference was observed. Moreover, the heating cost for the prefab electric Ondol system was more expensive than the conventional system, even though a heat loss was observed by the operation of the conventional system.
Exploring the Charge Compensation Mechanism of P2-Type Na0.6Mg0.3Mn0.7O2 Cathode Materials for Advanced Sodium-Ion Batteries
Authors: Cheng Chen , Ding Manling , Yan Tianran , Dai Kehua , Mao Jing , Zhang Nian , Zhang Liang , Guo Jinghua
Published: November 2020

P2-type sodium layered transition metal oxides have been intensively investigated as promising cathode materials for sodium-ion batteries (SIBs) by virtue of their high specific capacity and high operating voltage. However, they suffer from problems of voltage decay, capacity fading, and structural deterioration, which hinder their practical application. Therefore, a mechanistic understanding of the cationic/anionic redox activity and capacity fading is indispensable for the further improvement of electrochemical performance. Here, a prototype cathode material of P2-type Na0.6Mg0.3Mn0.7O2 is comprehensively investigated, which presents both cationic and anionic redox behaviors during the cycling process. By a combination of soft X-ray absorption spectroscopy and electroanalytical methods, we unambiguously reveal that only oxygen redox reaction is involved in the initial charge process, then both oxygen and manganese participate in the charge compensation in the following discharge process. In addition, a gradient distribution of Mn valence state from surface to bulk is disclosed, which could be mainly related to the irreversible oxygen activity during the charge process. Furthermore, we find that the average oxidation state of Mn is reduced upon extended cycles, leading to the noticeable capacity fading. Our results provide deeper insights into the intrinsic cationic/anionic redox mechanism of P2-type materials, which is vital for the rational design and optimization of advanced cathode materials for SIBs.
Smooth-Switching Control of Robot-Based Permanent-Magnet Synchronous Motors via Port-Controlled Hamiltonian and Feedback Linearization
Authors: Liu Anxing , Yu Haisheng
Published: November 2020

To solve the contradiction between dynamic performance and steady-state performance of the robot system, a smooth-switching control strategy is proposed. By combining robot and motor model, the complete model of the robot driving system is established. The single-loop Feedback Linearization (FL) controller and Port-Controlled Hamiltonian (PCH) controller based on the complete model are derived to ensure the rapidity and stability of the system respectively. A smooth-switching function based on position error is designed. It can ensure the smooth-switching between two controllers and avoid the instability caused by switch-switching. The proposed algorithm can make the robot system have good dynamic and steady performance. Simulation and experiment results demonstrate the effectiveness of the smooth-switch control strategy.
A Concept of Integration of a Vactrain Underground Station with the Solidarity Transport Hub Poland
Authors: Stryhunivska Olena , Gdowska Katarzyna , Rumin Rafał
Published: November 2020

This paper provides an analysis of a designed underground station infrastructure for vacuum tube high-speed trains for the planned mega transport hub in Poland. The potential of integrating the infrastructure of the station building with sealed low-pressure tubes system is analyzed. The Solidarity Transport Hub Poland is a planned mega hub to be located in Baranów Municipality, Poland, which is comprised of an airport, an airport city, a road, and railway infrastructure. It is to be integrated with the first route of vactrains in Poland. The aim of this paper is to design a hyperloop station building adequate for the advanced technology of low-pressure high-speed trains. Designing a hyperloop station is not trivial, due to technological aspects which have not been hitherto present in airport or railway planning and design, such as low-pressure zones or airlocks which determine possible passenger paths and evacuation roads. Both the mega airport and Polish hyperloop are in the planning stage, therefore, in this paper, available models and designs of the hyperloop station building and infrastructure are used in order to formulate recommendations for further development and identify critical issues related to the safety and reduction of passenger transit time. The main contribution of this paper is a model of the hyperloop station building which respects the principles of spatial planning and safety standards.
Drivers behind Residential Electricity Demand Fluctuations Due to COVID-19 Restrictions
Authors: Snow Stephen , Bean Richard , Glencross Mashhuda , Horrocks Neil
Published: November 2020

The COVID-19 pandemic rapidly reoriented the lives of billions of people across the globe toward working, learning, and subsisting from home. This paper examines the consequences of this disruption of electricity use in Australian households. Using high-frequency electricity monitoring from 491 houses and per-circuit monitoring and in-depth interviews with 17 households, the paper (1) compares changes in energy use before and during COVID-19 lockdown, (2) quantifies the key drivers of changes in energy use experienced by households during lockdown, and (3) tracks households’ interactions with energy use feedback. The findings identify significant increases in certain aspects of household electricity use directly related to COVID-19, including increased cooking and digital device use. Yet despite the government mandate requiring a large proportion of the population to remain at home, overall energy use among the majority of Queensland households monitored actually decreased during lockdown versus prior, driven primarily by a reduction in air conditioner use during lockdown as the weather cooled. Further, despite significant quantified and self-reported changes in energy use, users who had energy use feedback installed accessed their dashboards less during lockdown than they did prior. The paper discusses these results in the context of statistics on COVID-19 related energy demand fluctuations elsewhere, and the implications for the provision of energy use information to residents during significant disruptions such as lockdown.
Voltage Quality Enhancement of Grid-Integrated PV System Using Battery-Based Dynamic Voltage Restorer
Authors: Molla Emiyamrew Minaye , Kuo Cheng-Chien
Published: November 2020

The advancement of power electronic-based sensitive loads drives the power utilities’ devotion to power quality issues. The voltage disturbance could be happening due to fault conditions, switching of loads, energizing of transformers, or integration of highly intermittent energy sources such as PV systems. This research work attempts to enhance the voltage fluctuation of a sensitive load connected to a grid-integrated PV system using a battery-based dynamic voltage restorer (DVR). The proposed battery energy storage-based DVR has two separate controlling stages that are implemented at the DC–DC buck/boost converter of the battery and voltage source converter (VSC) system. Charging and discharging of the battery is operated based on the state-of-charge (SOC) value of the battery and the measured root mean square (RMS) voltage at the point of common coupling (PCC). The VSC of the DVR detection and reference generation control is done appropriately. In the detection control of the VSC, a combination of RMS and dq0 measurement techniques is used, whereas in the reference generation control, pre-fault strategy is implemented to restore both phase jump and magnitude distortions. Symmetrical and asymmetrical voltage sags scenarios are considered and the compensation demonstration is carried out using power system computer-aided design (PSCAD/EMTDC) software.
Desulfurization Performance of Choline Chloride-Based Deep Eutectic Solvents in the Presence of Graphene Oxide
Authors: Lim Chiau Yuan , Majid Mohd Faridzuan , Rajasuriyan Sarrthesvaarni , Mohd Zaid Hayyiratul Fatimah , Jumbri Khairulazhar , Chong Fai Kait
Published: November 2020

Extractive catalytic oxidative desulfurization (ECODS) is the one of the recent methods used in fuel desulfurization which involved the use of catalyst in the oxidative desulfurization of diesel fuel. This study is aimed to test the effectiveness of synthesized choline chloride (ChCl) based deep eutectic solvent (DES) in fuel desulfurization via ECODS method, with the presence of graphene oxide (GO) as catalyst and hydrogen peroxide (H2O2) as oxidant. In this study, 16 DESs based on choline chloride were synthesized using glycerol (GLY), ethylene glycol (EG), tetraethylene glycol (TEG) and polyethylene glycol (PEG). The characterization of the synthesized DES was carried out via Fourier transform infrared spectroscopy (FTIR) analysis, density, and viscosity determination. According to the screening result, ChCl-PEG (1:4) was found to be the most effective DES for desulfurization using ECODS method, with a removal of up to 47.4% of sulfur containing compounds in model oil in just 10 min per cycle after the optimization of the reaction parameters, and up to 95% desulfurization efficiency could be achieved by six cycles of desulfurization. It is found that the addition of GO as catalyst does not increase the desulfurization performance drastically; hence, future studies for the desulfurization performance of DESs made up from ChCl and PEG and its derivatives can be done simply by using extraction desulfurization (EDS) method instead of ECODS method, for cost reduction purpose and easier regulation of DES waste into environment.
The Effect of Emulsifying Protein and Addition of Condensed Tannins on n-3 PUFA Enriched Emulsions for Functional Foods
Authors: Cofrades Susana , Garcimartín Alba , Gómez-Estaca Joaquín , Sánchez-Muniz Francisco J. , Herranz Beatriz , Macho-González Adrián , Benedí Juana , Álvarez María Dolores
Published: November 2020

This paper examines the effect of the type of the emulsifying protein (EP) (sodium caseinate (SC) and whey protein isolate (WPI)) on both oil-in-water liquid-like emulsions (Es) and the corresponding cold gelled emulsions (GEs), and also the effect of addition of carob extract rich in condensed tannins (T). The systems, intended as functional food ingredients, were studied in various different respects, including rheological behaviour, in vitro gastrointestinal digestion with determination of the release of non-extractable proanthocyanidins (NEPA) from T, antioxidant activity and lipolysis. EP significantly affects the rheological behaviour of both Es and GEs. T incorporation produced a structural reinforcement of GEs, especially in the case of SC. The digests from Es displayed a higher antioxidant activity than those from GEs. T lipase inhibition was observed only in the formulations with WPI. Our results highlight the importance, in the design of functional foods, of analyzing different variables when incorporating a bioactive compound into a food or emulsion in order to select the better combination for the desired objective, owing to the complex interplay of the various components.
Unripe Black Raspberry (Rubus coreanus Miquel) Extract and Its Constitute, Ellagic Acid Induces T Cell Activation and Antitumor Immunity by Blocking PD-1/PD-L1 Interaction
Authors: Kim Ji Hye , Kim Young Soo , Kim Tae In , Li Wei , Mun Jeong-Geon , Jeon Hee Dong , Kee Ji-Ye , Choi Jang-Gi , Chung Hwan-Suck
Published: November 2020

Rubus coreanus Miquel (R. coreanus) is a unripen fruit of black raspberry native to eastern Asia. It is used as traditional oriental medicine and supplementary foods for centuries. Previous studies have shown that the R. coreanus extract (RCE) and its main constitute ellagic acid possess diverse biological activities. However, the effects of RCE on antitumor immunity and T cell function were not fully understood. The present study describes the anti-tumor effect of RCE in humanized PD-1 mice by blocking PD-1/PD-L1 interaction. Competitive enzyme-linked immunosorbent assay (ELISA) and pull down assay were performed to elucidate the binding properties of RCE in vitro. Cellular PD-1/PD-L1 blockade activities were measured by T cell receptor (TCR)-induced nuclear factor of activated T cells-luciferase activity in co-cultured cell models with PD-1/NFAT Jurkat and PD-L1/aAPC CHO-K1 cells. The in vivo efficacy of RCE was confirmed in humanized PD-1 mice bearing MC38 colorectal tumor. RCE and ellagic acid dose-dependently block the binding of PD-1 to PD-L1. Moreover, oral administration of RCE showed the potent anti-tumor activity similar to anti-PD-1 antibody. The present study suggests that RCE possesses potent anti-tumor effect via PD-1/PD-L1 blockade, and ellagic acid is the main compound in RCE. Thus, we provide new aspects of RCE as an immunotherapeutic agent.
Obesity and Related Type 2 Diabetes: A Failure of the Autonomic Nervous System Controlling Gastrointestinal Function?
Authors: Blasi Claudio
Published: November 2020

The pandemic spread of obesity and type 2 diabetes is a serious health problem that cannot be contained with common therapies. At present, the most effective therapeutic tool is metabolic surgery, which substantially modifies the gastrointestinal anatomical structure. This review reflects the state of the art research in obesity and type 2 diabetes, describing the probable reason for their spread, how the various brain sectors are involved (with particular emphasis on the role of the vagal system controlling different digestive functions), and the possible mechanisms for the effectiveness of bariatric surgery. According to the writer’s interpretation, the identification of drugs that can modulate the activity of some receptor subunits of the vagal neurons and energy-controlling structures of the central nervous system (CNS), and/or specific physical treatment of cortical areas, could reproduce, non-surgically, the positive effects of metabolic surgery.
The Importance of Optimal Gaze Direction on Deep Neck Flexor Activation in Chronic Neck Pain
Authors: Lee Byoung-Kwon , Seo Dong-Kwon
Published: November 2020

Chronic neck pain (CNP) patients have weak deep neck flexors (DNF) and a hyperactive sternocleidomastoid (SCM). The cranio-cervical flexion test (CCFT) promotes activation of the DNF and decreases activity of the SCM, promoting pain recovery, but research suggests SCM activation increases with increasing gaze direction. We aimed to investigate how DNF and SCM activation varies according to gaze direction in the CCFT, and to prescribe the appropriate gaze direction for CNP. Twenty-eight CNP subjects had their maximum strength pressure level determined by CCFT for strength (20–~30 mmHg) and at each of the measured pressures, DNF and SCM thickness in each of four gaze directions (0°, 20°, 40°, and 60°) was measured by ultrasound imaging. The DNF to SCM ratio varied significantly according to gaze direction (p < 0.05), with gaze directions of 20° and 0° being significantly different from 40° (p < 0.05). Although there was no significant difference in DNF activation according to gaze direction, there was in SCM activation (p < 0.05), with SCM 60° significantly different from SCM 20° and SCM 40° (p < 0.05). In order to increase DNF activation efficiency during the CCFT, SCM activation should be controlled, and a gaze direction below 20° is the most efficient. This can inform DNF training of CNP patients in a clinical environment.
Perception of COVID-19 Restrictions on Daily Life among Japanese Older Adults: A Qualitative Focus Group Study
Authors: Takashima Risa , Onishi Ryuta , Saeki Kazuko , Hirano Michiyo
Published: November 2020

The coronavirus disease 2019 (COVID-19) pandemic has exposed older adults to health and social risks. This study examined the perceptions of community-dwelling older adults regarding how COVID-19 restricted their daily lives. Six focus-group interviews were conducted with 24 participants (mean age, 78.2 ± 5.5 years) living in urban and rural areas in Japan. Then, a qualitative inductive content analysis was performed. Six themes were generated: “fear of infection and public, watchful eyes,” “consistency in daily personal life,” “pain from reducing my social life,” “readiness to endure a restricted life,” “awareness of positive changes in myself,” and “concern for a languishing society.” There was no change that would make their lives untenable, and they continued their daily personal lives at a minimum level. However, their social lives were reduced, which over the long term can lead to a lost sense of purpose in life. This was reported as an adverse factor in the development of other diseases and functional decline in previous studies. While there is no doubt that infection prevention is important, supporting older adults in engaging in activities that provide a sense of purpose in life could contribute to their present and future overall health including mental health.
Do Physical Activity and Personality Matter for Hair Cortisol Concentration and Self-Reported Stress in Pregnancy? A Pilot Cross-Sectional Study
Authors: Budnik-Przybylska Dagmara , Laskowski Radosław , Pawlicka Paulina , Anikiej-Wiczenbach Paulina , Łada-Maśko Ariadna , Szumilewicz Anna , Makurat Franciszek , Przybylski Jacek , Soya Hideaki , Kaźmierczak Maria
Published: November 2020

Background: Physical activity reduces psychosocial stress in pregnant women. Stress levels might be self-reported (psychosocial) or measured with biomarkers, one of which is hair cortisol concentration (HCC). Additionally, personality has been associated with stress and physical activity. Methods: The first aim of our study was to explore the differences in self-reported stress assessed by the Perceived Stress Scale (PSS) and in HCC with regard to physical activity level in pregnant (N = 29) and non-pregnant (N = 21) women. The second aim was to analyze the correlations among perceived stress, HCC, frequency of exercise and personality in the two groups separately. Results: There was a significant difference in frequency of exercise and self-reported stress between the two groups, with a lower level in pregnant women, but no differences in HCC and in personality were found. In the group of pregnant women, there was a significant negative correlation between HCC and frequency of exercise sessions, with the latter correlating positively with openness to experience. In the group of non-pregnant women, perceived stress negatively correlated with extraversion, agreeableness and emotional stability. HCC correlated negatively with conscientiousness. Conclusions: Our findings indicate the importance of physical activity programs dedicated to pregnant women for their life quality.
Can Physical Activity in Immersive Virtual Reality Be Attractive and Have Sufficient Intensity to Meet Health Recommendations for Obese Children? A Pilot Study
Authors: Polechoński Jacek , Nierwińska Katarzyna , Kalita Barbara , Wodarski Piotr
Published: November 2020

Immersive virtual reality (IVR) is a technology that blurs the line between the physical world and a digital environment. Using appropriate pointing devices, it is possible to engage in physical activity (PA). The main aim of the study was to assess the attractiveness and intensity of physical exercise while playing active video games (AVGs) in IVR on an omnidirectional treadmill by obese children and to present the results compared to health recommendations (PA). It was also assessed whether the AVGs storyline can effectively motivate the participants to undertake locomotor activity by increasing the intensity of their effort (moving in a limited space vs. having to follow a set route). Eleven children aged 8 to 12 years with diagnosed obesity participated in the experiment. The attractiveness of PA was assessed with a questionnaire, while the intensity of exercise was estimated on the basis of heart rate. The answers show that AVGs are attractive and more enjoyable for the respondents than conventional video games. All participants declared their willingness to practice this form of PA. The intensity of PA of obese children during two games was high but during the game where the player was supposed to follow a set route, it was significantly higher (83.3 ± 9.2% HRmax) than during the game whose storyline assumed moving in a limited space (77.4 ± 9.8% HRmax). Due to the high intensity of PA while playing the AVGs studied, it can be assumed that obese children can benefit for their health if the games are used on a regular basis. However, further research is needed to verify this thesis.
Symptom Occurrence and Distress after Heart Transplantation—A Nationwide Cross-Sectional Cohort Study
Authors: Dalvindt Marita , Nozohoor Shahab , Kisch Annika , Lennerling Annette , Forsberg Anna
Published: November 2020

Experiencing symptoms after heart transplantation may hamper the heart recipient’s self-management which can lead to negative effects. We know little about symptom occurrence and distress after heart transplantation, especially in relation to sociodemographic variables. The aim of the study was to explore self-reported symptom occurrence and distress after heart transplantation and their relationship with self-reported psychological well-being and sociodemographic factors. This multicenter, cross-sectional, cohort study is associated with the Swedish national Self-Management After Thoracic Transplantation study (SMATT). Two questionnaires were distributed at the heart recipients’ yearly follow-up, one to five years post-transplant at three Swedish university hospitals from 2014–2017. In a total 79 heart recipients, 54 men and 25 women, with a mean age 53 years returned the questionnaires. Symptoms occurred differently depending on type and duration of follow-up. The most common symptoms, trembling hands, and decreased libido were also the most distressing. Heart recipients most burdened by symptoms were those younger than 50 years, not working, with poor psychological well-being or living alone. Fatigue explained more than 60% of the variation in transplant specific well-being. In conclusion this study points at the target groups within the heart transplant population that needs person centered symptom management support where the focus should be on side-effects of the medication i.e., trembling hands as well as the patients’ sexual health.
Vitamin D Knowledge, Attitudes, and Behaviors in Young Danish Women with a Non-Western Ethnic Minority Background—A Questionnaire Survey
Authors: Özel Erdinc , Cantarero-Arevalo Lourdes , Jacobsen Ramune
Published: November 2020

The prevalence of vitamin D deficiency in women with a non-Western ethnic minority background in Nordic countries is high. The aim of this study was to assess vitamin D knowledge, attitudes, and behaviors in women with a non-Western ethic minority background living in Denmark. A validated vitamin D knowledge, attitudes, and behaviors’ questionnaire was translated into Danish, piloted, and distributed via relevant Facebook groups. The responses were analyzed using parametric and non-parametric tests for descriptive and bivariate analyses. In total, 254 women who considered themselves having a non-Western ethnic minority background responded to the questionnaire. The median age (IQR) was 25 (23–33) years old; 32% had a professional bachelor’s, 28% had high school, and 22% had a master’s or higher university education. Participants scored higher on vitamin D general knowledge (scores above 80 on the scale 0–100) compared to vitamin D nutrition knowledge or vitamin D attitudes and behaviors (scores around 60 on the scale 0–100). In conclusion, the vitamin D knowledge among study participants—i.e., young well-educated non-Western ethnic minority women in Denmark—was pretty good. The further examination of vitamin D knowledge, attitudes, and behaviors should explore specifics related to nationality and religion and focus on less-educated non-Western ethnic minority women in Denmark and other Nordic countries.
A Feasibility Study for Implementation “Health Arcade”: A Study Protocol for Prototype of Multidomain Intervention Based on Gamification Technologies in Acutely Hospitalized Older Patients
Authors: Cuevas-Lara César , Izquierdo Mikel , Zambom-Ferraresi Fabiola , Sáez de Asteasu Mikel L. , Marín-Epelde Itxaso , Chenhuichen Chenhui , Zambom-Ferraresi Fabricio , Ramírez-Vélez Robinson , García-Hermoso Antonio , Casas-Herrero Álvaro , Capón-Sáez Amaya , Lozano-Vicario Lucia , Criado-Martín Irene , Sánchez-Latorre Marina , Antoñanzas-Valencia Cristina , Martínez-Velilla Nicolás
Published: November 2020

The aim of this article is to present the research protocol for a study that will evaluate the feasibility of implementation of Health Arcade prototype multidomain intervention based on physical and cognitive training using gamification technologies at improving care for older people hospitalized with an acute illness. A total of 40 older people will be recruited in a tertiary public hospital at Pamplona, Spain. The intervention duration will be four to nine consecutive days. Additionally, the patients will receive encouragement for maintaining active during hospital stay and for reducing sedentary time. Primary implementation-related outcomes will be the adherence to treatment (i.e., number of games and days completed during the intervention period), reaction or response time, and number of success and failures in each game per day. Secondary implementation-related outcomes will be self-perceived grade of difficulty, satisfaction, enjoyment per game and session, and self-perceived difficulties in handling the prototype hardware. Other health-related outcomes will also be assessed such as functional capacity in activities of daily living, mood status, quality of life, handgrip strength, physical activity levels, and mobility. The current study will provide additional evidence to support the implementation of multidomain interventions designed to target older persons with an acute illness based on friendly technology. The proposed intervention will increase accessibility of in-clinical geriatrics services, improve function, promote recovery of the health, and reduce economic costs.
A Scoping Review of the Relationship between Running and Mental Health
Authors: Oswald Freya , Campbell Jennifer , Williamson Chloë , Richards Justin , Kelly Paul
Published: November 2020

Poor mental health contributes significantly to global morbidity. The evidence regarding physical benefits of running are well-established. However, the mental health impacts of running remain unclear. An overview of the relationship between running and mental health has not been published in the last 30 years. The purpose of this study was to review the literature on the relationship between running and mental health. Our scoping review used combinations of running terms (e.g., Run* and Jog*) and mental health terms (general and condition specific). Databases used were Ovid(Medline), Ovid(Embase), ProQuest and SportDiscus. Quantitative study types reporting on the relationships between running and mental health were included. Database searches identified 16,401 studies; 273 full-texts were analysed with 116 studies included. Overall, studies suggest that running bouts of variable lengths and intensities, and running interventions can improve mood and mental health and that the type of running can lead to differential effects. However, lack of controls and diversity in participant demographics are limitations that need to be addressed. Cross-sectional evidence shows not only a range of associations with mental health but also some associations with adverse mental health (such as exercise addiction). This review identified extensive literature on the relationship between running and mental health.
Moderators of Perceived Effort in Adolescent Rowers During a Graded Exercise Test
Authors: Schmitz Gerd
Published: November 2020

Physical activity promotes mental health. A key factor is self-regulation. In the field of sports, self-regulation is related to the psychophysiological competence of rating of perceived effort (RPE). It was reported that adolescents have lower RPE competencies than adults, and it was hypothesized that this effect depends on physiological and cognitive development. The present study investigated in a sample of adolescents whether the RPE is related to basic cognitive competencies. Twelve rowers performed cognitive tests and a graded exercise test on a rowing ergometer, in which they continuously rated their perceived effort. Objective load measures and subjective perceptions were highly correlated (rho = 0.95–0.99). Furthermore, these correlations were inter-individually moderated by measures of mental speed and spontaneous flexibility. The results confirm the significance of basal cognitive competencies for conscious load perception. It is discussed whether regular sport has beneficial effects on the development of RPE competencies by enhancing cognitive regulation.
Long but Unreal Lockdowns in Latin America. Comment on Chen, Y.T.; Yen, Y.F.; Yu, S.H.; Su, E.C. An Examination on the Transmission of COVID-19 and the Effect of Response Strategies: A Comparative Analysis. Int. J. Environ. Res. Public Health 2020, 17, E5687
Authors: Idrovo Alvaro J.
Published: November 2020

Lockdowns have been important elements of epidemic control over time. During the COVID-19 pandemic, they have been implemented in many countries, at very different times, and accompanied by school or workplace closures, restrictions on mass gatherings, and public transport closure in different combinations. Recent evidence published in the International Journal of Environmental Research and Public Health suggests that SARS-CoV-19 transmission is diminished when strict lockdowns, contact tracing, and good public cooperation are implemented. However, in Latin America, not all lockdowns are real, and rapid increases in a few weeks in the number of infected, hospitalized, and deceased populations have been observed. In these cases, the effect of lockdowns is weakening of democracy.
A Randomised Controlled Trial to Evaluate the Administration of the Health Improvement Card as a Health Promotion Tool: A Physiotherapist-Led Community-Based Initiative
Authors: Bai Yiwen , Wu Xubo , Tsang Raymond CC , Yun Ruisheng , Lu Yan , Dean Elizabeth , Jones Alice YM
Published: November 2020

A randomised controlled trial was conducted to evaluate the administration of the Health Improvement Card (HIC) on lifestyle practices and biometric variables in community-dwelling Chinese participants. Adults living in Shanghai were randomly assigned to either the HIC-intervention or control group. Measurements/assessments were conducted at baseline and three-month follow-up. Supervised physiotherapy students administered the HIC and four standardised questionnaires related to health and wellbeing. Both groups received a health promotion education pamphlet. Based on participants’ HIC biometric and lifestyle scores, students prescribed lifestyle, and exercise advice to the HIC-intervention group. 171 individuals (39 men, 132 women) (mean age 68.4 ± 9.7 y) participated. At follow-up, body mass index (BMI) and waist circumference decreased significantly in the HIC-intervention group. Furthermore, the number of participants in the HIC-intervention group categorised as low risk regarding their physical activity and dietary practices, increased by 32.2% and 20%, respectively. Changes in standardised questionnaire scores did not meet minimum clinically importance differences in either group. This is the first study to demonstrate that HIC-informed health promotion education can improve people’s lifestyle practices, thereby, objective biometric variables. Evaluation of the effect of HIC-informed lifestyle education on some biometric parameters (blood pressure and BMI) may warrant a longer timeframe.
Impact of a Positive Viral Polymerase Chain Reaction on Outcomes of Chronic Obstructive Pulmonary Disease (COPD) Exacerbations
Authors: Gunasekaran Kulothungan , Ahmad Mudassar , Rehman Sana , Thilagar Bright , Gopalratnam Kavitha , Ramalingam Sathish , Paramasivam Vijayakumar , Arora Ashish , Chandran Arul
Published: November 2020

Introduction: More than 15 million adults in the USA have chronic obstructive pulmonary disease. Chronic obstructive pulmonary disease (COPD) places a high burden on the healthcare system. Many hospital admissions are due to an exacerbation, which is suspected to be from a viral cause. The purpose of this analysis was to compare the outcomes of patients with a positive and negative respiratory virus panel who were admitted to the hospital with COPD exacerbations. Methods: This retrospective cohort study was conducted in the Geisinger Healthcare System. The dataset included 2729 patient encounters between 1 January 2006 and 30 November 2017. Hospital length of stay was calculated as the discrete number of calendar days a patient was in the hospital. Patient encounters with a positive and negative respiratory virus panel were compared using Pearson’s chi-square or Fisher’s exact test for categorical variables and Student’s t-test or Wilcoxon rank-sum tests for continuous variables. Results: There were 1626 patients with a total of 2729 chronic obstructive pulmonary disease exacerbation encounters. Nineteen percent of those encounters (n = 524) had a respiratory virus panel performed during their admission. Among these encounters, 161 (30.7%) had positive results, and 363 (69.3%) had negative results. For encounters with the respiratory virus panel, the mean age was 64.5, 59.5% were female, 98.9% were white, and the mean body mass index was 26.6. Those with a negative respiratory virus panel had a higher median white blood cell count (11.1 vs. 9.9, p = 0.0076). There were no other statistically significant differences in characteristics between the two groups. Respiratory virus panel positive patients had a statistically significant longer hospital length of stay. There were no significant differences with respect to being on mechanical ventilation or ventilation-free days. Conclusion: This study shows that a positive respiratory virus panel is associated with increased length of hospital stay. Early diagnosis of chronic obstructive pulmonary disease exacerbation patients with positive viral panel would help identify patients with a longer length of stay.
Radiation Damage in Biomolecules and Cells
Authors: Carante Mario P. , Ballarini Francesca
Published: November 2020

Ionizing radiation is widely used in medicine, both as a diagnostic tool and as a therapeutic agent [...]
Empagliflozin Inhibits Basal and IL-1β-Mediated MCP-1/CCL2 and Endothelin-1 Expression in Human Proximal Tubular Cells
Authors: Pirklbauer Markus , Bernd Maximilian , Fuchs Lisa , Staudinger Petra , Corazza Ulrike , Leierer Johannes , Mayer Gert , Schramek Herbert
Published: November 2020

SGLT2 inhibitors (SGLT2i) slow the progression of chronic kidney disease; however, evidence for the underlying molecular mechanisms is scarce. We investigated SGLT2i-mediated effects on differential gene expression in two independent human proximal tubular cell (HPTC) lines (HK-2 and RPTEC/TERT1) at the mRNA and protein levels under normoglycemic conditions, utilizing IL-1β as a pro-inflammatory mediator. Microarray hybridization identified 259 genes that were uniformly upregulated by IL-1β (10 mg/mL) and downregulated by empagliflozin (Empa) (500 nM) after 24 h of stimulation in two independent HPTC lines (n = 2, each). The functional annotation of these genes identified eight pathway clusters. Among 12 genes annotated to the highest ranked cluster (enrichment score, 3.51), monocyte chemoattractant protein-1/CC-chemokine ligand 2 (MCP-1/CCL2) and endothelin-1 (ET-1) were selected for verification at mRNA and protein levels based on their established involvement in the early pathogenesis of chronic kidney disease: IL-1β upregulated basal MCP-1/CCL2 (15- and 19-fold) and ET-1 (3- and 8-fold) mRNA expression, while Empa downregulated basal MCP-1/CCL2 (0.6- and 0.5-fold) and ET-1 (0.3- and 0.2-fold) mRNA expression as early as 1 h after stimulation and for at least 24 h in HK-2 and RPTEC/TERT1 cells, respectively. The co-administration of Empa inhibited IL-1β-mediated MCP-1/CCL2 (0.2-fold, each) and ET-1 (0.2-fold, each) mRNA expression as early as 1 h after ligand stimulation and for at least 24 h in both HPTC lines, respectively. This inhibitory effect of Empa on basal and IL-1β-mediated MCP-1/CCL2 and ET-1 mRNA expression was corroborated at the protein level. Our study presents novel evidence for the interference of SGLT2 inhibition with tubular inflammatory response mechanisms under normoglycemic conditions that might account for SGLT2i-mediated nephroprotection.
Light-Induced Oxidase Activity of DNAzyme-Modified Quantum Dots
Authors: Żukowski Krzysztof , Kosman Joanna , Juskowiak Bernard
Published: November 2020

Here, we report the synthesis of a quantum dot (QD)-DNA covalent conjugate to be used as an H2O2-free DNAzyme system with oxidase activity. Amino-coupling conjugation was carried out between amino-modified oligonucleotides (CatG4-NH2) and carboxylated quantum dots (CdTe@COOH QDs). The obtained products were characterized by spectroscopic methods (UV-Vis, fluorescence, circular dichroizm (CD), and IR) and the transmission electron microscopy (TEM) technique. A QD-DNA system with a low polydispersity and high stability in aqueous solutions was successfully obtained. The catalytic activity of the QD-DNA conjugate was examined with Amplex Red and ABTS (2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonate)) indicators using reactive oxygen species (ROS) generated by visible light irradiation. The synthesized QD-DNAzyme exhibited enhanced catalytic activity compared with the reference system (a mixture of QDs and DNAzyme). This proved the assumption that the covalent attachment of DNAzyme to the surface of QD resulted in a beneficial effect on its catalytic activity. The results proved that the QD-DNAzyme system can be used for generation of the signal by light irradiation. The light-induced oxidase activity of the conjugate was demonstrated, proving that the QD-DNAzyme system can be useful for the development of new cellular bioassays, e.g., for the determination of oxygen radical scavengers.