bluuebunny/crossref_metadata_2025 huggingface dataset:
Bursal Hexapeptide, A Potential Immunomodulator, Inhibits Tumor Cells Proliferation via p53 Signaling Pathway
Authors: Zhang Cong , Zhou Jiangfei , Li Shengnan , Cai Kairui , Guo Xiangling , Liao Chengshui , Wang Chen
Published: June 2018

Background:

The Bursa of Fabricius (BF) is acknowledged as the central humoral immune organ
unique to birds. Bursal Hexapeptide (BHP, AGCCNG) is a recently reported bursal-derived bioactive peptide.
However, there are few reports of the molecular basis of the mechanism on immune induction and potential
antitumor activity of BHP.

Method:

In this paper, Gene microarray analyses demonstrated that BHP regulated expression of 1347 genes,
of which 832 were up-regulated and 515 were down-regulated. Differentially expressed genes involved in
various pathways were identified, of which 16 pathways were associated with immune responses and tumorigenic
processes.

Result:

Specifically, we found that BHP selectively inhibited tumor cell proliferation. Furthermore, BHP
enhanced antitumor factor p53 luciferase activity and stimulated expression of p53, p21, and p130 protein.
Moreover, we observed that the inhibitory effect of BHP on cell proliferation and premature senescence in a
p53-dependent manner.

Conclusion:

Taken together, we uncovered that BHP may be involved in antitumor suppressor via p53 signaling
pathway.
Cytotoxic and Apoptotic Effects of Novel Pyrrolo[2,3-d]Pyrimidine Derivatives Containing Urea Moieties on Cancer Cell Lines
Authors: Kilic-Kurt Zühal , Bakar-Ates Filiz , Karakas Bahriye , Kütük Özgür
Published: June 2018

Background:

Pyrrolo[2,3-d]pyrimidines have been recently reported to have anticancer activities
through inhibition of different targets such as, Epidermal Growth Factor Receptor (EGFR) tyrosine kinase,
Janus Kinase (JAK), mitotic checkpoint protein kinase (Mps1), carbonic anhydrase, MDM-2. On the other hand,
aryl urea moieties which are found in some tyrosine kinase inhibitors such as Sorafenib and Linifanib have
aroused recent attention as responsible for anticancer activities. The aims of this paper are to synthesize pyrrolo[
2,3-d]pyrimidine derivatives containing urea moiety and evaluate their anti-cancer activity against human
lung cancer cell line (A549), prostate cancer cell line (PC3), human colon cancer cell line (SW480) and human
breast cancer cell line (MCF-7).

Methods:

A series of new pyrrolo[2,3-d]pyrimidines containing urea moieties have been synthesized as
Scheme 1. In vitro cytotoxicity of target compounds were evaluated against, SW480, PC3, A549 and MCF-7
human cancer cell lines using a MTT assay. In order to evaluate the mechanism of cytotoxic activity of
compounds 9e, 10a and 10b, having the best cytotoxic activity, Annexin V binding assay, cell cycle analysis
and western blot analysis were performed.

Results:

Among the target compounds, 10a (IC50 = 0.19 µM) was found to be the most potent derivative against
PC3 cells. Compound 10b and 9e showed the strong cytotoxic activity against MCF-7 and A549 cells with IC50
value of 1.66 µM and 4.55 µM, respectively. Flow cytometry data suggest that the cytotoxic activity of the
compounds on cancer cells might be mediated by apoptosis revealing a significant increase in the percentage of
late apoptotic cells and causing a cell cycle arrest at different stages. Western blot analysis of apoptosis marker
demonstrated that these compounds induce apoptosis through the intrinsic pathway.

Conclusion:

Compound 9e displayed the strongest cytotoxicity against A549 cancer cell line, and induced late
apoptosis in A549, as confirmed by cell cycle arrest in G0/G1 phase. In addition, compound 9e reduced expression
of the anti-apoptotic protein Bcl-2 and enhanced expression of the pro-apoptotic protein Bax, besides increased
caspase-9 and caspase-3, as well as cleavage of PARP levels. These results suggest that compound 9e
showed a cytotoxic effect in A549 cells through activation of the mitochondrial apoptotic pathway. Further
studies will be undertaken in our laboratory to improve cytotoxic activity of compound 9e and to identify the
biological targets of 9e which are responsible for anticancer activity.
Hydrogen Sulfide in Physiological and Pathological Mechanisms in Brain
Authors: Kumar Mohit , Sandhir Rajat
Published: June 2018

Background & Objective: Hydrogen sulfide [H2S] has been widely known as a toxic gas
for more than 300 years in the scientific community. However, the understanding about this small
molecule has changed after the discovery of involvement of H2S in physiological and pathological
mechanisms in brain. H2S is a third gasotransmitter and neuromodulator after carbon monoxide [CO]
and nitric oxide [NO]. H2S plays an important role in memory and cognition by regulating long-term
potentiation [LTP] and calcium homeostasis in neuronal cells. The disturbances in endogenous H2S
levels and trans-sulfuration pathway have been implicated in neurodegenerative disorders like Alzheimer’s
disease, Parkinson disease, stroke and traumatic brain injury. According to the results obtained
from various studies, H2S not only behaves as neuromodulator but also is a potent antioxidant,
anti-inflammatory and anti-apoptotic molecule suggesting its neuroprotective potential.

Conclusion:

Recently, there is an increased interest in developing H2S releasing pharmaceuticals to
target various neurological disorders. This review covers the information about the involvement of
H2S in neurodegenerative diseases, its molecular targets and its role as potential therapeutic molecule.
Fibrinolytic, Anti-Inflammatory and Cytotoxic Potentialities of Extracts and Chemical Constituents of Manglicolous Lichen, Graphis ajarekarii Patw. & C. R. Kulk
Authors: Tatipamula Vinay Bharadwaj , Vedula Girija Sastry
Published: June 2018

Background:

Lichens which are betide to mangroves are termed as Manglicolous Lichens
(ML). As these ML are habituated under stress conditions, they are screened for unique metabolites
and biological activities.

Objective:

The study aimed to establish the chemical and biological profile of ML, Graphis
ajarekarii.

Methods:

The Ethyl Acetate Extract of G. ajarekarii (EAE) was subjected to chromatographic techniques
and the obtained isolates were characterized by spectroscopic analysis. The hydroalcoholic extract
of G. ajarekarii (AE), EAE, isolates and Hydroalcoholic Extract of host (HE) were evaluated for
fibrinolytic (fibrin clot method), in vitro (protein denaturation method) and in vivo (formalin-induced
rat paw oedema assay), anti-inflammatory and cytotoxicity (MTT assay) activities.

Results:

Chemical investigation of the EAE led to the isolation of two known compounds namely
atranorin (1) and ribenone (2), which were confirmed by spectral data. The AE and EAE gradually
lysed the fibrin clot with 94.54 and 65.07%, respectively, at 24 h. The AE inhibited protein denaturation
of about 88.06%, while the standard (Indomethacin) with 93.62%. Similarly, the in vivo antiinflammatory
analysis of AE (200 mg/mL) showed potent reduction of rat paw oedema than the
standard, whereas EAE and 1 depicted moderate depletion. In addition, the AE revealed prominence
inhibition on MCF-7, DU145 and K-562 with IC50 values of 69.5, 42.5 and 38 µg/mL, respectively,
whereas the HE exhibited mild inhibitory profile against fibrin clot, inflammation and cancer.

Conclusion:

From the results, it can be concluded that the G. ajarekarii has an aptitude to act
against coagulation, inflammation and cancer cells.
Microsponge Based Gel of Tea Tree Oil for Dermatological Microbial Infections
Authors: Yadav Erosh , Rao Rekha , Kumar Sunil , Mahant Sheefali , Vohra Prakriti
Published: June 2018

Objective:

Tea Tree Oil (TTO), derived from Melaleuca alternifolia possesses broad spectrum antimicrobial potential. However, its therapeutic utility is impaired due to its high volatility, poor aqueous solubility and low stability in the presence of light, oxygen and temperature. The present study was attempted to investigate Ethyl Cellulose (EC) microsponges (MSs) as topical carriers for TTO to circumvent above mentioned limitations.

Methods:

TTO MSs were prepared using quasi emulsion solvent diffusion technique. The effect of formulation variables on the production yield, entrapment efficiency, particle size and drug release of MSs was investigated. The optimized MSs were dispersed into Carbopol 934 gel and evaluated for drug release, skin irritation, antibacterial activity and photostability.

Results:

Scanning electron microscopy revealed spherical and porous nature of TTO microsponges. The optimized MSs possessed particle size of 36.98 μm, percent entrapment efficiency of 93.12% and percent cumulative drug release of 79.18%, respectively. MS-loaded gels were found nonirritant. In addition, TTO loaded MS gels exhibited good stability. Antimicrobial effect of TTO MS gel showed broader zones of inhibition in comparison to TTO gel.

Conclusion:

The findings of our study suggest that MS loaded gel could prove alternative to conventional antibacterial formulations for dermatological microbial infections.
5V to 6kV DC-DC Converter Using Switching Regulator with Cockcroft-Walton Voltage Multiplier for High Voltage Power Supply Module
Authors: Azmi Nor A. , Murad Sohiful A.Z. , Harun Azizi , Ismail Rizalafande C.
Published: June 2018

Background:

This paper describes the design of 5 V to 6 kV DC-DC converter by using a switching
regulator with Cockroft-Walton (C-W) voltage multiplier for a high voltage power supply module.

Methods:

The proposed design consists of Pulse Width Modulation (PWM) controller circuit, voltage
multiplier, and feedback signal. A single unit of 5 V input triggers LT1618 controller circuit to generate
20 V which then produces 300 V from LT8331 output that is connected to diode-capacitor multiplier
circuit to achieve final 6 kV. A negative feedback signal is required to stabilize an output voltage. With
the implementation of C-W voltage multiplier technique, the output is boosted up as required from the
input signal voltage 5 V DC.

Results:

The LTspice simulation results indicate that the proposed DC converter can generate 6.20 kV.
Line regulation of 17 % and the load regulation of 14 % are obtained based on the proposed design.

Conclusion:

The proposed design is suitable for high voltage power supply module.
Calcium Metabolism Indicators in Patients with Generalized Periodontitis and Hypertension
Authors: Vivcharenko T I , Rozhko M M
Published: June 2018

The objective of the study is to determine the level of calcium in patients with hypertension of the II degree and generalized periodontitis of the II degree.There were examined 30 patients with hypertension of the II degree with generalized periodontitis of the II degree. Patients’ age ranged from 35 to 54 years.  These patients were in the main group. Treatment of patients included taking the medicine “Ca-D3 NIKOMED”.The control group included 10 patients without general somathic pathology and with healthy periodontitis of the same age.  The results obtained were subject to variational and statistical processing.The analyses were carried out before and 3 months after the treatment. The level of general Ca in patients with generalized periodontitis of the II degree and hypertension of the II degree before the treatment was 1.66±0.03 mmol/l (p<0.001) (norm 2.15-2.5 mmol/l). In the patients of control group this figure was 2.33±0.04 mmol/l (p<0.001).After 3 months the level of general Ca in patients with generalized periodontitis of the II degree and hypertension of the II degree was 1.87±0.03 mmol/l (p<0.001).The level of ionized Ca in patients with generalized periodontitis of the II degree and hypertension of the II degree before the treatment was 0.36± 0.01 mmol/l (p<0.001); after the treatment the level of ionized Ca was 0.41±0.01 mmol/l (p<0.001). The level of ionized Ca in control group patients was 1.03±0.02 mmol/l (p<0.001).We can conclude: according to the analysis of levels of general and ionized calcium in serum of patients with generalized periodontitis of the II degree and hypertension of the II degree we can conclude that these indexes are lower than normal; patients with generalized periodontitis of the II degree and hypertension of the II degree have increased levels of general calcium and ionized calcium in serum after taking the drug “Ca-D3 NIKOMED”during 3 months.
Pedagogical Aspects of Adaptation of First-Year Ukrainian and Foreign Russian-Speaking Students of the Department of Medicine
Authors: Ivanchenko Elena , Melnikova Oksana , Malakhova Svetlana , Prokopchenko Alexander
Published: June 2018

Timely adaptation of first-year students to new living conditions and educational activities is one of the most important challenges of high school. The objective of the research was to study and analyze the problems of adaptation to high school experienced by Ukrainian and foreign first-year students of the Department of Medicine. The questionnaires offered to students showed that the main adaptation difficulties arise in the educational sphere. At the end of the first term, most students positively assessed the degree of their adaptability and noted the leading role of groupmates and friends in its formation. The possible directions of higher educational institution activity facilitating the process of adaptation of first-year students to high school were analyzed. According to the results of the questionnaire survey which indicated that the main difficulties were a lack of leisure time and academic overload, there is a need to optimize academic overload, as well as to inform psychologists, curators and lecturers about the formation of students’ ability to rationally schedule their time and the development of independent working skills.
Questionnaire of Third-Year Medical Students of the Ivano-Frankivsk National Medical University Undergoing Shortened Course of Study About Delivered Lecture in Clinical Anatomy and Operative Surgery
Authors: Kavyn Vasyl
Published: June 2018

The educational process in Ukraine, that is undergoing reform due to the introduction of the European Credit Transfer System, requires the improvement of the basic forms of education, namely lectures. This is due to the dynamic development of scientific advances in medicine, the appearance of innovative technologies, the growth of requirements for the formation of a competitive specialist, a doctor who constantly needs to improve his/her knowledge and practical skills in particular. The questionnaire of student audience helps clarify the advantages and disadvantages of the teaching material presented during the lecture and the level of mastering the key moments of the lecture by students. We present the results of a questionnaire of students about the lecture delivered at the Department of Cinical Anatomy and Operative Surgery.
E-STÜDYO İÇERİSİNDE TOPLAM SES ŞİDDET DÜZEYİ VE SAYISAL ANALİZİ
Authors: Armağan Hamit , Yiğit Tuncay
Published: June 2018

E-Stüdyo Uzaktan Eğitim
alanında online(senkron) eğitim veren üniversitelerde/kurumlarda ders alan
öğrencilerin derse aktif katılımlarını ve öğretim elemanlarının ilgi çeken
dersler oluşturmalarını sağlayan ortamlardır. Bu ortamlarda bulunan eğitim
teknolojilerinin en üst potansiyelde kullanımı ve adaptasyonu ile uzaktan
eğitimin başarısını artırmak amacıyla tasarlanmış ve geliştirilmiş bir
modeldir. Bu çalışmada e-stüdyo içerisinde ses kaynakları tarafından
oluşturulan sesler için toplam ses şiddet düzeyi ve reverbasyon hesaplamaları geliştirilen
bir yazılımla hesaplanmıştır.  Yapılan
hesaplamalara göre ses şiddet düzeyi modeli oluşturulmuş ve ses kalitesinin
artırılması içinde bazı iyileştirme önerileri sunulmuştur.
Sleep Tracking and Exercise in Patients With Type 2 Diabetes Mellitus (Step-D): Pilot Study to Determine Correlations Between Fitbit Data and Patient-Reported Outcomes (Preprint)
Authors: Weatherall James , Paprocki Yurek , Meyer Theresa M , Kudel Ian , Witt Edward A
Published: June 2018

BACKGROUND

Few studies assessing the correlation between patient-reported outcomes and patient-generated health data from wearable devices exist.

OBJECTIVE

The aim of this study was to determine the direction and magnitude of associations between patient-generated health data (from the Fitbit Charge HR) and patient-reported outcomes for sleep patterns and physical activity in patients with type 2 diabetes mellitus (T2DM).

METHODS

This was a pilot study conducted with adults diagnosed with T2DM (n=86). All participants wore a Fitbit Charge HR for 14 consecutive days and completed internet-based surveys at 3 time points: day 1, day 7, and day 14. Patient-generated health data included minutes asleep and number of steps taken. Questionnaires assessed the number of days of exercise and nights of sleep problems per week. Means and SDs were calculated for all data, and Pearson correlations were used to examine associations between patient-reported outcomes and patient-generated health data. All respondents provided informed consent before participating.

RESULTS

The participants were predominantly middle-aged (mean 54.3, SD 13.3 years), white (80/86, 93%), and female (50/86, 58%). Use of oral T2DM medication correlated with the number of mean steps taken (r=.35, P=.001), whereas being unaware of the glycated hemoglobin level correlated with the number of minutes asleep (r=−.24, P=.04). On the basis of the Fitbit data, participants walked an average of 4955 steps and slept 6.7 hours per day. They self-reported an average of 2.0 days of exercise and 2.3 nights of sleep problems per week. The association between the number of days exercised and steps walked was strong (r=.60, P<.001), whereas the association between the number of troubled sleep nights and minutes asleep was weaker (r=.28, P=.02).

CONCLUSIONS

Fitbit and patient-reported data were positively associated for physical activity as well as sleep, with the former more strongly correlated than the latter. As extensive patient monitoring can guide clinical decisions regarding T2DM therapy, passive, objective data collection through wearables could potentially enhance patient care, resulting in better patient-reported outcomes.
Hubungan Kebiasaan Mengkonsumsi Kopi dengan Tekanan Darah Pada Dewasa Muda
Authors: Bistara Difran Nobel , Kartini Yanis
Published: June 2018

Latar Belakang: Indonesia merupakan salah satu produsen kopi terbesar di dunia, tetapi memiliki nilai konsumsi kopi per kapita yang masih relatif rendah yaitu sekitar 70.000 ton/tahun atau 0,5 kg/orang/tahun. Kopi sering dikaitkan dengan sejumlah faktor risiko penyakit jantung koroner, termasuk meningkatkan tekanan darah dan kadar kolesterol darah karena kopi mempunyai kandungan kalium, polifenol, dan kafein. Kafein memiliki sifat meningkatkan tekanan darah, sedangkan kalium dan Polifenol memiliki sifat menurunkan tekanan darah.Tujuan: Penelitian ini bertujuan untuk mengidentifikasi hubungan antara kebiasaan mengkonsumsi kopi dengan tekanan darah pada dewasa muda.Metode: Jenis penelitian yang digunakan dalam penelitian ini adalah kolerasional dengan desain penelitian cross sectional. Variabel independennya adalah kebiasaan mengkonsumsi kopi dan variabel dependennya adalah tekanan darah. Pengambilan sampel dilakukan di Demak Jaya kelurahan Tembok Dukuh kecamatan Bubutan, Surabaya pada bulan Agustus-September 2017. Besar sampel sejumlah 40 responden yang diambil dengan teknik purposive sampling. Data yang diperoleh dikumpulkan dengan menggunakan lembar kuesioner dan observasi. Klaifikasi skala pengumpulan data ordinal dengan uji statistik yang digunakan pada penelitian ini adalah korelasi Spearman Rank.Hasil: Hasil uji statistik Spearman Rho p=0.465 (α=0.05), menunjukkan bahwa H1 ditolak, sehingga dapat disimpulkan tidak ada hubungan kebiasaan mengkonsumsi kopi dengan tekanan darah pada dewasa muda di Demak Jaya kelurahan Tembok Dukuh kecamatan Bubutan, surabaya.Kesimpulan: Peningkatan tekanan darah juga dapat disebabkan oleh faktor lain seperti stasus ekonomi, kegemukan, psikososial (stres), merokok, aktivitas fisik, konsumsi alkohol berlebih dan konsumsi garam.
IbM-Kelompok Yasinan Dusun Tangar: Deteksi Dini Faktor Risiko Penyakit Kardiovaskular
Authors: Rosjidi Cholik Harun , Mayasari Rika , Putri Dianita Rifqia
Published: June 2018

The Community empowerment Program aims to improve the early awareness of cardiovascular disease (heart and strok) attacks on yasinan religious groups in Tangar, Jenangan sub-district, Ponorogo regency. Design to achieve these objectives with yasinan group empowerment program with two activities (1) provide health education to all group members and (2) Training of examination skills Blood Pressure, Blood Sugar, Cholesterol and First Aid in Emergency Heart and strok.. Target group program yasinan Tangar Jenangan, Ponorogo. Health education activities were held twice yasinan group meetings and training activities held 1 day. The yasinan group sends 10 people as representatives. The success of community service programs is assessed on the basis of increased knowledge values, passing the first emergency relief skills test and the realization of commitment in the form of a commitment statement. The first program form of training was held on July 31, 2017 with the following results: The training was attended by 10 members of the yasinan group. Training to improve knowledge and skills of early detection of risk factors for heart disease and strok (P = 0.000) Of the 10 participants 8 of them successfully passed the first aid skill test in an accident. Week 3 realizes the group's commitment to early detection of cardiovascular disease risk factors independently. These results illustrate the approach of effective religious groups to increase aware of cardiovascular disease attacks.
Peningkatan Produktivitas Usaha Pengeringan Tepung Sagu Masyarakat melalui Introduksi Teknologi Tepat Guna di Kalimantan Barat
Authors: Sholahuddin Sholahuddin , Hutajulu Josua Parulian , Gusmayanti Evi
Published: June 2018

Potentially, production of dried sago starch in Desa Arang Limbung, Sungai Raya, Kubu Raya District can be increased in term of quality and quantity. To achieve these, several problems have to be solved, i.e clean water availability for washing sago starch, washing mechanization to increase production capacity, and drying machine that efficient in operation and investment. Through IbM grant 2017, we have installed water filtration, sago washer, and solar dryer with greenhouse effect concept. Water filtration significantly increase the quality of water for use in washing sago starch and resulted in improved quality of sago starch. Mechanization of sago washing process and implementation of greenhouse effect dryer have increase capacity and efficiency of sago starch production. Generally, the introduced technology has been supported and accepted by stakeholder in Desa Arang Limbung. Further, the technology may support government policy in accelaration of food consumption diversity based on local resources.
Community Economic Empowerment through Cultivation Of Enceng Gondok Program using Community Engagement Program Approach in West Aceh Regency Post Conflict and Natural Disaster Earthquake and Tsunami 2004
Authors: Santoso Harri , Anita Anita , Muliadi Muliadi , Mayanti Debi Agus
Published: June 2018

Menurut data Biro Pusat Statistik (Guci, 2017) disebutkan bahwa Aceh Barat adalah satu kabupaten termiskin di wilayah Provinsi Aceh. Salah satu penyebabnya adalah konflik yang pernah terjadi dan bencana alam gempa bumi dan tsunami 2004. Tulisan ini bertujuan untuk menjelaskan Program Kuliah Pengabdian Masyarakat (KPM) Inovatif Universitas Membangun Desa (UMD) pemberdayaan tanaman enceng gondok di wilayah Aceh Barat dengan segala keunggulan, keterbatasan, dan keunikan pada setiap langkahnya dengan menggunakan wawancara dan observasi langsung sebagai alat pengambilan data. Program KPM Inovatif UMD adalah sebuah program yang dilaksanakan oleh Lembaga Pengabdian Masyarakat UIN Ar Raniry yang bekerja sama dengan KOMPAK Indonesia. Program ini dilaksanakan oleh dosen sebagai supervisor, mahasiswa sebagai peserta, dan LP2M UIN Ar Raniry sebagai panitia pelaksana di tiga desa di Kecamatan Arongan Lambalek, Kabupaten Aceh Barat. KPM Inovatif UMD dilakukan selama enam bulan, yaitu Oktober 2016 hingga Maret 2017 dengan tiga tahapan: tahap penyiapan lembaga, tahap penyiapan sumber daya manusia pengrajin enceng gondok, dan tahap penyiadaan pasar bagi kerajinan enceng gondok. Kegiatan ini telah melahirkan lima kelompok usaha produktif dengan menghasilkan produk kerajinan berbahan dasar enceng gondok. Kesimpulan kegiatan ini adalah masyarakat sangat antusias dalam mengembangkan produk kerajinan berbahan dasar enceng gondok untuk dapat menyejahterakan kehidupan keluarga, namun masih terkendala dengan kualitas produk yang dihasilkan dan tempat pemasaran yang potensial di kemudian hari. Oleh karena itu, diperlukan peran pemerintah dalam melanjutkan program pemberdayaan masyarakat ini.
Perbaikan Manajemen Pemeliharaan dalam Rangka Mendukung Pembibitan Kambing Kacang bagi Warga di Kecamatan Bone Pantai Kabupaten Bone Bolango
Authors: Ilham Fahrul , Mukhtar Muhammad
Published: June 2018

The purpose of this Community Service Program is to provide knowledges and skills for the community in Bone Pantai Sub district about the goat raising to support the animal breeding program by improving the maintenance management. This activities have been implemented on the livestock herders of Kacang goat which is located in Lembah Hijau Village and Tolotio Village, Bone Pantai Sub District, Bone Bolango Distric. The method used in conducting the community empowerment is giving the teory and simulation upon the community members and continuing with practice directly in the field. Program activities that have been implemented are: the goat house making, goats selection, silage making, feeding, injection prostaglandin F2α (PGF2α), prevention and treatment of the sick goats, and organic fertilizer making. Based on the result and discussion, it is concluded that the program of kacang goat breeding is an important step in order to maintain its purity and sustainability. The support program activities that can be done are: management improvement of the maintenance and housing, selection of prospective does and bucks, appropriate feeding as the the goats need, application of reproductive technology by modification of the hormonal system, prevention and treatment of the disease routinely, and recycling the manure into organic fertilizer. To make the programs sustainable, it is necessary to build communication network between the farmers and government and the industry so that the products of kacang goat breeding programs can be marketed and provide economic value for the community in Kecamatan Bone Pantai.
Mendorong Partisipasi Bina Keluarga Lansia (BKL) dalam Mewujudkan Tujuh Dimensi Lansia Tangguh di Desa Sumbersari, Moyudan, Sleman
Authors: Astuti Eka Zuni Lusi , Winarni Tri
Published: June 2018

Bina Keluarga Lansia (BKL) is one of the government programs to empower the elderly and their families. Through this program the elderly are expected to apply 7 dimensi lansia tangguh so that the elderly are physically, emotionally, spiritually, intellectually, socially, professionally vocational and environmentally empowered. The existence of BKL is needed in every hamlet. However, in Sumbersari Village, Moyudan, Sleman, out of five BKLs already established, only one BKL, BKL Mugi Waras, with a paripurna status that applied 7 dimensi lansia tangguh in its activities. Therefore, the community service program of the development of the targeted village aims to replicate BKL Mugi Waras to other BKL which have basic status. The activity used for community service were socialization and education in various training for strengthening BKL institutionally. The program has shown positive impacts on understanding managing BKL and applying 7 dimensi lansia tangguh on its activities.
Custo-Benefício da Logística Reversa de Embalagens Vazias de Agroquímicos no Brasil
Authors: Yanagihara Damaris , Bragagnolo Cassiano
Published: June 2018

O agronegócio tem se tornado cada vez mais importante na economia brasileira. Dado a crescente discussão acerca dos impactos ambientais do agronegócio no Brasil e o aumento significativo do uso de defensivos agrícolas, observou-se ser de grande importância uma análise dos impactos ambientais e sociais que a destinação correta das embalagens de agroquímicos pode causar. Sendo assim, o principal objetivo deste estudo foi fazer uma análise custo-benefício social e ambiental do processo de recolhimento e direcionamento das embalagens de defensivos agrícolas no território brasileiro. Após os cálculos dos custos e benefícios, constatou-se que tal processo ainda apresenta-se inviável do ponto de vista econômico. Porém, ressalta-se que a falta de dados quantitativos acerca do impacto à saúde e ao meio ambiente poderiam mudar consideravelmente os resultados.
Pedagogia Reggio Emilia no Brasil e o Projeto Político Pedagógico
Authors: Silva Tatiane , Pacagnella Luiz Eduardo
Published: June 2018

Pensando na complexidade e singularidade dos conceitos que determinada concepção pedagógica implica, na sua importância e relevância para a compreensão do processo de ensino e nas possíveis contribuições para a discussão educacional, esse trabalho pretendeu analisar e identificar as principais percepções de professores e gestores a respeito do processo de implementação da concepção pedagógica de Reggio Emilia no Projeto Político Pedagógico de uma instituição particular de ensino brasileira. Como metodologia utilizada realizou-se revisão bibliográfica, juntamente com aplicação de questionários envolvendo professores (pedagogos); professores especialistas (Artes, Educação Física, Expressão Corporal, Música); gestores pedagógicos (coordenadores) e gestores administrativos. Somado a isso, foram realizadas observações diretas do ambiente escolar na escola lócus da pesquisa. A partir das respostas obtidas, verificou-se que apesar da proposta reggiana em seus pressupostos originais preconizar uma educação baseada no espírito coletivo de colaboração entre comunidade escolar, famílias e alunos, pôde-se verificar na análise do caso brasileiro que as decisões e ações para a implementação da abordagem reggiana não ocorreram de forma coletiva, mas sim de forma centralizadora, tendo como núcleo os gestores pedagógicos e administrativos, não havendo a participação da comunidade escolar. Tal fato se evidencia como uma das principais causas da dificuldade de implementação de maneira efetiva da proposta reggiana na instituição pesquisada e da efetivação de um Projeto Político Pedagógico com uma abordagem educativa diferenciada.
Prática da sustentabilidade de uma instituição financeira na Amazônia Legal: um estudo de caso
Authors: Pontes Filipe Rios , Marè Renata Maria
Published: June 2018

Em meio à atual conjuntura de impactos causados pelo desenvolvimento humano, as empresas devem criar mecanismos e formas de avaliação da sustentabilidade para operacionalizar o conceito de desenvolvimento sustentável. O presente trabalho teve o objetivo de avaliar e analisar a sustentabilidade de uma instituição financeira, atuante na região da Amazônia Legal Brasileira, por meio de um estudo de caso, com a aplicação das metodologias de mensuração da sustentabilidade “Global Reporting Initiative” [GRI] e Método de Avaliação dos Indicadores de Sustentabilidade Organizacional [M.A.I.S.], além de análises documentais. A avaliação da sustentabilidade mostrou que a instituição é sustentável nas dimensões social, econômica e ambiental, mas necessita melhorar nos aspectos referentes à dimensão cultural.
Custos e viabilidade da implantação de uma unidade armazenadora de grãos no Mato Grosso
Authors: Vieira Rafael Antonio , Dalchiavon Flávio Carlos
Published: June 2018

A capacidade de armazenagem no Brasil, infraestrutura que exige elevadas somas de investimentos não tem acompanhado o ritmo de crescimento das safras ao longo dos anos. Sendo assim, objetivou-se avaliar os custos e a viabilidade da implantação de uma unidade armazenadora de grãos na cidade de Sorriso no estado do Mato Grosso no ano de 2017. Para o dimensionamento da unidade foi considerada a capacidade máxima de colheita de uma fazenda que possui 1500 hectares disponíveis para a semeadura de soja e milho. No cálculo de viabilidade econômica foram utilizados parâmetros como a taxa interna de retorno, ponto de equilíbrio econômico, valor presente líquido e “payback” do investimento. Os resultados obtidos para o investimento de uma infraestrutura capaz de processar a produção desta fazenda levam a uma estimativa de custo de aproximadamente R$ 4.035.754,00, sendo feito por financiamento de 100%, através da linha de crédito Programa para Construção e Ampliação de Armazéns [PCA], a 8,5% de juros ao ano, ao longo de dez anos. O empreendimento obtém receitas anuais de R$ 1.144.042,20 e custos totais anuais de R$ 525.137,00, um valor presente líquido de R$ 25.090,99 e uma taxa interna de retorno de 6,98%, o ponto de equilíbrio foi de R$ 356.224,72 e o prazo de retorno do investimento de dez anos, mostrando que a implantação deste empreendimento pode ser uma opção viável econômica e financeiramente.
TACI-Deficient Macrophages Protect Mice Against Metaflammation and Obesity-Induced Dysregulation of Glucose Homeostasis
Authors: Liu Lunhua , Inouye Karen Etsuko , Allman Windy Rose , Coleman Adam Steven , Siddiqui Shafiuddin , Hotamisligil Gökhan Siddik , Akkoyunlu Mustafa
Published: June 2018

Transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) is a receptor for the TNF superfamily cytokines, B cell–activating factor (BAFF), and A proliferation–inducing ligand (APRIL). Here, we demonstrate that TACI-deficient mice subjected to high-fat diet (HFD) are protected from weight gain and dysregulated glucose homeostasis. Resistance to HFD-induced metabolic changes in TACI-deficient mice does not involve TACI-mediated adipogenesis. Instead, accumulation of M2 macrophages (Mϕs), eosinophils, and type 2 innate lymphoid cells in visceral adipose tissue (VAT) is implicated in the protection from obesity-induced assaults. In support of this hypothesis, adoptively transferred TACI-deficient peritoneal or adipose tissue Mϕs, but not B cells, can improve glucose metabolism in the obese host. Interestingly, the transferred TACI-deficient Mϕs not only home to host VAT but also trigger the accumulation of host M2 Mϕs and eosinophils in VAT. The increase in host M2 Mϕs in VAT is likely a result of eosinophil recruitment in response to eotaxin-2 produced by TACI-deficient Mϕs. Insulin signaling experiments revealed that IL-10 secreted by TACI-deficient Mϕs is responsible for maintaining adipocyte insulin sensitivity. Thus, the adoptive transfer experiments offer a model where TACI-deficient Mϕs accumulate in VAT and protect against metaflammation and obesity-associated dysregulation of glucose metabolism.
Credit Risk Management of Kumari Bank Ltd. Nepal
Authors: Sahani Kalpana , Sahani Soni , Bansal Sundip , Shakya Deepak , Shrestha Binay
Published: June 2018

Banks are always faced with different types of risks that may have a potentially negative effect on their business. Risk-taking is an inherent element of banking and, indeed, profits are in part the reward for successful risk taking in business. On the other hand, excessive and poorly managed risk can lead to losses and thus endanger the safety of a bank's depositors. Risks are considered warranted when they are understandable, measurable, controllable and within a bank’s capacity to readily withstand adverse results. Sound risk management systems enable managers of banks to take risks knowingly, reduce risks where appropriate and strive to prepare for a future, which by its nature cannot be predicted.Financial institutions are subject to a number of risks such as Credit risk, Market risk management, Foreign exchange risk, Operational risk, and Liquidity risk. Although credit risk has always been of primary concern to these institutions, its importance became paramount during the recent financial crisis. The crisis exposed the shortcomings of existing risk management systems, and several firms saw significant losses resulting from failure of their counterparties to deliver on contracts. Firms may also be worried about a second recession, which makes credit risk a top priority.
PENGARUH NILAI BUDAYA SUNDA DALAM UPAYA PENINGKATAN KESEJAHTERAAN PSIKOLOGIS KORBAN BENCANA TANAH LONGSOR
Authors: Kadiyono Anissa Lestari , Harding Diana
Published: June 2018

Permasalahan psikososial adalah hal yang akan menyertai ketika bencana alam terjadi, termasuk diantaranya adalah bencana tanah longsor yang terjadi di daerah Ciloto Cipanas, Cianjur, Jawa Barat. Daerah ini seringkali mengalami bencana alam, khususnya tanah longsor dikarenakan posisi tanah yang labil dan curah hujan yang tinggi. Pada saat bencana longsor terjadi, maka terdapat korban yang mengakibatkan permasalahan tersendiri bagi pembangunan daerah dan masyarakat dalam melanjutkan hidup mereka. Penelitian ini dilakukan pada korban bencana tanah longsor di Ciloto-Cipanas pada tanggal 21 Januari 2014. Tujuan dari penelitian ini adalah untuk menganalisa nilai apakah dalam diri korban tanah longsor yang dapat meningkatkan kesejahteraan psikologis mereka. Data dikumpulkan melalui interviu mendalam, observasi, diskusi kelompok, dan penyebaran kuesioner. Bagi masyarakat Cianjur, terdapat nilai-nilai dasar yang secara turun-menurun menjadi dasar hidup mereka, yaitu Ngaos, Mamaos, dan Maenpo. Berdasarkan hasil penelitian, nilai Sunda yang penduduk Cianjur anut ini dapat meningkatkan kesejahteraan psikologis, sehingga para korban tanah longsor memiliki semangat untuk melanjutkan hidup dan mewujudkan rencana mereka ke depan. Hal ini dapat dimanfaatkan dalam membuat program intervensi penanganan bencana alam melalui nilai budaya. Kata Kunci : Nilai Religiusitas, Intervensi Psikososial, Kesejahteraan Psikologis, BencanaTanah Longsor
KONSELING KARIR KELOMPOK COGNITIVE INFORMATION PROCESSING UNTUK MENINGKATKAN PENGAMBILAN KEPUTUSAN KARIR SISWA
Authors: Nurrega Resi Gusti , Wahyuningsih Hepi , Gusniarti Uly
Published: June 2018

Penelitian ini bertujuan untuk menguji pengaruh konseling karir kelompok cognitive information processing untuk meningkatkan kemampuan pengambilan keputusan karir siswa. Penelitian ini menggunakan desain Pretest-Posttest Control Group Design. Partisipan dalam penelitian ini adalah 16 orang siswa kelas XI di SMAN “X” Yogyakjarta yang berjenis kelamin perempuan dan laki-laki, berusia 17 tahun dan dibagi dalam dua kelompok. Setelah dilakukan proses random, maka terpilih satu kelompok (n=8) sebagai kelompok eksperimen dari SMAN”X” yang menerima perlakuan berupa konseling karir kelompok CIP. Satu kelompok lainnya (n=8) sebagai kelompok kontrol. Skala career thought inventory yang dibuat sendiri oleh peneliti yang dipergunakan sebagai alat ukur. Uji hipotesis menggunakan analisis non-parametrik berupa Mann Whitney U Test untuk menguji perbedaan nilai berdasarkan kelompok, yaitu eksperimen dan kontrol. Hasil pengujian menunjukkan bahwa konseling karir kelompok berpengaruh dalam menigkatkan kemampuan pengambilan keputusan karir siswa (Z = -3,313, p = 0,000, dimana p < 0,05).Kata kunci : Pengambilan keputusan karir, Cognitive Information Processing, Konseling karir
Eremopyrum (Ledeb.) Jaub. & Spach, a new genre for the Flora of western Europe (Iberian Peninsula)
Authors: Cueto Romero Miguel , Fuentes Carretero Julián , Blanca López Gabriel
Published: June 2018

Se cita por primera vez en la Península Ibérica y en Europa Occidental la presencia de Eremopyrum orientale (L.) Jaub. & Spach, un taxon anual que se desarrolla en los medios semiáridos de la Hoya de Guadix (Granada). Las características ambientales propias de estos ambientes (sustratos poco favorables para el desarrollo de la vida vegetal junto a una alta irregularidad intra e inter anual de las precipitaciones) parecen ser la causa de no haber sido localizada hasta ahora. Esas mismas características ambientales y la, aparentemente imparable, expansión de las actividades antropocéntricas nos hacen considerar este taxon como amenazado bajo la categoría de En Peligro (EN) con el criterio:  A4ac; B1ac(i,ii,iii,iv)+2ac(i,ii,iii,iv)Key words: Flora, Europa, Poaceae, Eremopyrum.Palabras clave: Flora, Europa, Poaceae, Eremopyrum.
The effect of heat stress on time spent lying by cows in a housing system
Authors: Herbut Piotr , Angrecka Sabina
Published: June 2018

Dairy cows are exposed to heat stress, the risk of which is increasing due to climate change. This could result in significant changes in the cows’ lying time behaviour. The presented study shows the relationship between heat stress determined with the use of the Temperature Humidity Index (THI) and the daily lying time of 40 Holstein-Friesian dairy cows. Based on the calculated value of THI, two periods were specified, a neutral period (with a maximum daily THI value below 68) and warm period (with minimal daily THI value above 73). The obtained results were processed using analysis of the Spearman’s correlation coefficient with significance at P<0.05. The results showed a decrease in daily total lying time between the neutral and warm periods from 11.3 to 9.4 h/d. During the warm period, the correlation between cows’ lying time and increased THI shows that the relationship is significant inversely proportional, but in the neutral period that correlation was not significant. A decrease in the percentage of the lying cows and average lying time per hour was also noticeable between the daytime and night-time in warm periods, which was 2 times less than in the neutral period.
Effects of rearing system and feeding intensity on the fattening performance and slaughter value of young crossbred bulls
Authors: Nogalski Zenon , Pogorzelska-Przybyłek Paulina , Sobczuk-Szul Monika , Purwin Cezary , Modzelewska-Kapituła Monika
Published: June 2018

The aim of this study was to determine the effects of rearing system and feeding intensity on the fattening performance and slaughter value of 38 young crossbred bull calves. The calves were raised naturally with nurse cows (NC) or were fed milk replacer (MF) until 150 days of age. During the rearing period the NC calves were healthier and had higher average daily gain (by 0.15 kg) compared to the MF calves. After a 30-day transition period, the animals were fattened in intensive (I) and semi-intensive (SI) systems from 181 to 560 days of age. During the fattening period, the bulls were fed ad libitum a total mixed ration (TMR) composed of grass silage and concentrate. The concentrate to silage ratio, on a DM basis, was 25:75 (SI) and 40:60 (I). The MF calves had lower BW at the end of the fattening period compared to the NC calves but the rearing system had no effects on daily gain during the fattening period. Compensatory growth was not observed during fattening. During the fattening period, a higher proportion of concentrate in the ration contributed to higher feed intake, higher feed efficiency and more desirable carcass characteristics. Three-rib cuts from the carcasses of the I bulls had significantly (P<0.05) higher fat content and lower bone content compared to the carcasses of the SI bulls. The longissimus thoracis muscle of the I bulls had higher (P<0.01) intramuscular fat content compared to the SI bulls.
Relationship of arctic fox (Alopex lagopus L.) sperm morphology with age of males, sperm concentration, ejaculate volume and acrosin activity
Authors: Stasiak Karolina , Kondracki Stanisław , Iwanina Maria
Published: June 2018

The aim of the study was to determine the relationship of sperm morphology with age of males, ejaculate concentration and volume, as well as with acrosin activity determined in sperm acrosome extracts. The study used manually collected ejaculates from 9 male arctic foxes, including 6 young males aged one year and 3 older males (between 3 and 5 years of age). All of the 39 ejaculates used in the study were classified as normal based on motility exceeding 70%. The ejaculates collected from the foxes were evaluated for volume, sperm concentration and frequency of morphological changes including primary and secondary defects. The spermiograms of the male arctic foxes were classified according to a six-grade subjective scale. In addition, acrosin activity was determined in the sperm acrosome extracts. The data were analysed using the criteria of male age, sperm concentration, ejaculate volume, and acrosin activity. The morphology of arctic fox spermatozoa was dependent on the age of the male. A greater number of morphologically altered spermatozoa tended to occur in the ejaculates of young foxes, which were in their first breeding season. In addition, statistical analysis revealed positive relationships between the frequency of morphological changes in sperm and their ejaculate concentration. In contrast, there were no significant correlations between the percentages of morphologically changed spermatozoa and the ejaculate volume and the content of acrosin, which is an indicator of acrosomal integrity. Semen quality is dependent on the number of sperm in ejaculate with morphological defects which prevent oocyte fertilization. Therefore, morphological assessment of semen, which covers both the number and type of morphological changes, is highly useful when selecting appropriate males for reproduction.
Behavioural and physiological responses of West African Dwarf Goat dams and kids subjected to short-term separation
Authors: Iyasere Oluwaseun Serah , James Ikechuckwu Joseph , Williams Tolulope Julius , Daramola James Olamitubo , Lawal Kabir Olumide , Oke Oyegunle Emmanuel , Iyasere Emmanuel
Published: June 2018

Nineteen West African Dwarf (WAD) goats were used to investigate the physiological and behavioural responses of dams and kids to short-term separation. The dams were naturally mated with bucks and after parturition the kids remained with their respective dams for 5 weeks. Thereafter, the dams were separated from their kids for 10 minutes / week for three weeks (week 5 – 7). Physiological indicators, namely, eye temperature (ET), heart rate (HRT) and blood glucose (GLUC) were taken from each dam, while the ET and HRT were taken from the kids before and after the separation. The behaviours of the dams and kids were recorded during the separation period at the 7th week. Changes (before minus after) in the physiological parameters (ET, HRT and GLU) for the three weeks were analysed using repeated measures ANOVA while the behavioural data were analysed using non parametric test (SPSS statistical package). The ΔGLUC of WAD dams was greater at the 5th than 7th week. At the 5th week also, the ΔET was greater in dams with single kids than those with twins. Litter size did not influence the behaviour of the dams during separation. A significant correlation was established between ΔHRT and urination in dams. Although sex of the kids had no significant effect on both the physiological and behavioural indicators monitored, negative correlations were established between vocalization bouts and escape attempts (r = −0.516, P < 0.01), duration of vocalisation and escape attempts (r = −0.427, P < 0.05). In conclusion, only WAD dams showed physiological responses indicative of stress during the period of separation.