bluuebunny/crossref_metadata_2025 huggingface dataset:
Le plan S ne sera pas le dernier mot de l’ouverture des publications scientifiques
Authors: Leduc Michèle , Graner François
Published: July 2019

Faisant suite à la très riche discussion amorcée dans le numéro 61 de Reflets de la physique avec la tribune libre « Le Plan S – késako ? » [1], nous proposons ici une discussion qui complète les informations et les analyses données par la Commission des publications de la SFP.
Rationale perioperative Antibiotikatherapie in der Thoraxchirurgie
Authors: Engelhardt Michael Jan , Bornemann Susanne , Pfannschmidt Joachim , Rüssmann Holger , Schönfeld Nicolas , Tiedt Nicola , Tönnies Mario , Bauer Torsten T.
Published: July 2019

Hintergrund Infektiöse Komplikationen nach lungenresezierenden Eingriffen sind mit erheblicher perioperativer Morbidität und Mortalität verbunden. Neben anderen Faktoren beeinflusst sowohl die perioperative Antibiotikaprophylaxe als auch das Management der postoperativen Pneumonie das Behandlungsergebnis. Ein lokaler Behandlungspfad soll helfen, eine rationale perioperative Antibiotikatherapie zu realisieren.

Methoden Wir analysierten mikrobiologische Ergebnisse von 200 Patienten vor und nach lungenresezierenden Eingriffen von Oktober 2013 bis Oktober 2014. Unter Berücksichtigung der aktuellen Leitlinien, der lokalen Erreger- und Resistenzsituation sowie Prinzipien der Antibiotic Stewardship wurde ein Behandlungspfad für die perioperative Antibiotikatherapie entwickelt.

Ergebnisse Mehrheitlich wurden in der präoperativen (62%) und in der postoperativen Phase (78%) gramnegative Erreger nachgewiesen. Der Anteil der Erreger mit intrinsischer Resistenz gegenüber der gängigen perioperativen Antibiotikaprophylaxe war sowohl in der präoperativen (21%) als auch in der postoperativen Phase (39%) bedeutsam. Diese Erkenntnisse wurden in den lokalen Behandlungspfad integriert.

Schlussfolgerung Die gängige perioperative Antibiotikaprophylaxe erfasst nur teilweise das Erregerspektrum der präoperativen tracheobronchialen Besiedelung sowie der postoperativen Pneumonie. Sie sollte daher nicht über den Operationszeitpunkt hinaus fortgeführt werden. Eine postoperative Pneumonie sollte nach den Grundsätzen einer nosokomialen Pneumonie therapiert werden und die lokale Erreger- und Resistenzsituation berücksichtigen.
Sexueller Missbrauch von Kindern durch katholische Priester seit 2009: Verlauf und relative Häufigkeit im Vergleich zur männlichen Allgemeinbevölkerung
Authors: Dreßing Harald , Dölling Dieter , Hermann Derik , Horten Barbara , Hoell Andreas , Voss Elke , Salize Hans-Joachim
Published: July 2019

Anliegen Untersucht wird die Häufigkeit der sexuellen Missbrauchsbeschuldigungen und der einschlägigen Strafanzeigen gegen katholische Priester und Diakone in den Jahren von 2009 – 2015.

Methode Für die Jahre 2009 – 2015 wird eine jährliche Quote der Beschuldigungen berechnet. In einem zweiten Schritt wird die Quote der einschlägigen Strafanzeigen gegen Priester mit den Tatverdächtigenbelastungszahlen der männlichen Allgemeinbevölkerung verglichen.

Ergebnisse Die Quote des sexuellen Missbrauchs von Kindern beschuldigter Priester im Untersuchungszeitraum liegt zwischen 25,5/100 000 und 55,5/100 000 Priester. Die Tatverdächtigungsbelastungszahl bei Männern der Allgemeinbevölkerung liegt in den Jahren von 2009 – 2015 zwischen 17,6 und 20,0/100 000, die Quote der einschlägigen Strafanzeigen gegen Priester liegt zwischen 8,4 und 31,7/100 000.

Diskussion Die Quote katholischer Priester, die für einen sexuellen Missbrauch von Kindern disponiert sind, hat im Untersuchungszeitraum nicht abgenommen.
Copper-Catalyzed Carbene Insertion into the Sulfur–Sulfur Bond of RS–SCF2H/SCF3 under Mild Conditions
Authors: Hong Xin , Lu Long , Shen Qilong
Published: July 2019

A copper-catalyzed carbene insertion into the sulfur–sulfur bond of trifluoromethyl/difluoromethyl/diphenyldisulfides under mild conditions has been developed. Diverse dithioketal derivatives were synthesized in moderate to good yields in an atom-economic process.
Palladium-Catalyzed Carbonylative Synthesis of Benzogerminones
Authors: Chen Bo , Wu Xiao-Feng
Published: July 2019

A novel and practical procedure for the synthesis of benzogerminones by carbonylative cyclization has been developed. With Pd(PPh3)4 as the catalyst and DABCO as the base, the desired benzogerminones were isolated in moderate to good yields with good functional group tolerance. To the best of our knowledge, this is the first procedure for benzogerminones synthesis.
Radiohalogenation of Organic Compounds: Practical Considerations and Challenges for Molecular Imaging
Authors: Sutherland Andrew
Published: July 2019

In the last few decades, advances in molecular imaging technologies have had a major impact on many aspects of healthcare. In particular, radiohalogenated compounds have been used for non-invasive visualization of human anatomy, for the diagnosis of disease and in drug development programs. As a consequence of these advances, a range of novel synthetic radiochemical methods have been reported that allow more effective and efficient radiohalogenation from a broader range of precursors. In developing new radiochemical methods, special requirements are required to optimize the incorporation of highly radioactive, short-lived, isotopically labelled reagents. This article highlights the key practical considerations and challenges encountered when utilizing the most commonly used radiohalogens in nuclear medicine.

1 Introduction

2 Synthetic Challenges for Radiohalogenation

2.1 Radiofluorination

2.2 Radioiodination

3 Conclusions and Future Outlook
A Simple Synthesis of Densely Substituted Benzofurans by Domino Reaction of 2-Hydroxybenzyl Alcohols with 2-Substituted Furans
Authors: Makarov Anton S. , Kekhvaeva Anna E. , Chalikidi Petrakis N. , Abaev Vladimir T. , Trushkov Igor V. , Uchuskin Maxim G.
Published: July 2019

The Brönsted acid-catalyzed cascade synthesis of densely substituted benzofurans from easily available salicyl alcohols and biomass-derived furans has been developed. The disclosed sequence includes the intermediate formation of 2-(2-hydroxybenzyl)furans that quickly rearrange into functionalized benzofurans. The established protocol was applied for the total synthesis of sugikurojinol B.
Hip disability and osteoarthritis outcome score (HOOS): um estudo de validação intercultural da versão na língua portuguesa
Authors: Machado Rodrigo Kruchelski , Casagrande André Augusto , Pereira Gustavo Roberto , Vissoci João Ricardo Nickenig , Pietrobon Ricardo , Ferreira Ana Paula Bonilauri
Published: July 2019

Objetivo Escalas traduzidas e validadas são de grande importância, pois podem ser utilizadas por pesquisadores que estudam diferentes populações com o mesmo problema. O objetivo do presente estudo foi traduzir, adaptar culturalmente e validar a escala Hip Disability and Osteoarthritis Outcome Score (HOOS) para a língua portuguesa.

Métodos O HOOS foi traduzido do inglês para a língua portuguesa, traduzido de volta para o inglês e submetido a um comitê de especialistas. Foi administrado a 100 pacientes com osteoartrite de quadril. A avaliação psicométrica incluiu a análise fatorial; medidas de confiabilidade interna, confiabilidade de teste-reteste em 7 dias e a comparação de validade de conteúdo com a versão brasileira da Escala de Dor Crônica Graduada (GCPS, na sigla em inglês).

Resultados A análise fatorial demonstrou uma solução de cinco fatores. A confiabilidade de teste-reteste mostrou um alto grau de consistência interna para as 5 subescalas (dor e dificuldades físicas, 0,97 no 1° dia e 0,93 aos 7 dias; dor e dificuldade em sentar, deitar e levantar, 0,93 no 1° dia e 0,89 aos 7 dias; dificuldade em flexionar o joelho, 0,92 no 1° dia e 0,83 aos 7 dias; dificuldade de caminhada, 0,88 no 1° dia e 0,87 aos 7 dias; qualidade de vida, 0,80 no 1° dia e 0,35 aos 7 dias). A validade de conteúdo foi estabelecida durante a comparação da versão brasileira da GCPS.

Conclusões Uma versão brasileira do HOOS foi desenvolvida com confiabilidade e validade adequadas. Isso facilitará a avaliação clínica do quadril em uma grande população de pacientes e entre diferentes culturas.
Indicações da neurotomia dos nervos geniculares por radiofrequência para o tratamento da osteoartrite do joelho: uma revisão de literatura
Authors: Ariel de Lima Diego , Gonçalves Marcelo Carvalho Krause , Grando Souterland Thiago Correia e Sá , Cintra Thiago Luiz de Lima , Pinto Dilamar Moreira , Gonçalves Romeu Krause
Published: July 2019

A osteoartrite é uma das patologias mais frequentes e incapacitantes na atualidade, principalmente do joelho. Dentre as abordagens possíveis para osteoartrite, a neurotomia dos nervos geniculares por radiofrequência vem se destacando. Todavia, por se tratar de um procedimento relativamente novo, as indicações para realização ainda não estão bem definidas. O principal objetivo desta revisão foi identificar as principais indicações do uso da radiofrequência para o tratamento da osteoartrite do joelho na literatura médica. Foi realizada revisão da literatura em janeiro de 2018, através de pesquisa nas bases de dados PubMed, Clinicalkey e Google Scholar. Após revisão dos principais artigos no assunto, foi concluído que as principais indicações do uso da radiofrequência para o tratamento da osteoartrite do joelho foram: pacientes com osteoartrite grau 3 e 4 da classificação de Kellgren-Lawrence, com dor de moderada a severa e falha do tratamento conservador, principalmente idosos; persistência da dor, mesmo após realizado artroplastia total de joelho; pacientes com indicação de artroplastia total de joelho e que se recusam a submeter-se ao tratamento cirúrgico.
Osteocondroma retroescapular como diagnóstico diferencial de escápula alada
Authors: Oliveira Marco Aurélio de , Alfaro Yuri , Kotzias Neto Anastácio , Korman Mário César
Published: July 2019

Objetivo O objetivo do presente trabalho é relatar as características clínicas de pacientes pediátricos com diagnóstico de osteocondroma retroescapular submetidos a tratamento cirúrgico, entre os anos de 2003 e 2017.

Métodos Série de casos, analítica, descritiva e retrospectiva de sete pacientes com diagnóstico de osteocondroma retroescapular.

Resultados A média de idade dos pacientes analisados foi de 9,5 anos, sendo 71% deles do sexo masculino. O tempo médio entre o início dos sintomas e o procedimento cirúrgico foi de 1,2 anos. Aproximadamente 71% dos pacientes apresentaram osteocondroma na escápula direita, e 57,1% dos casos foram classificados como sésseis. Ao exame clínico, observou-se pseudoescápula alada em 85,7%, crepitação em 71,4%, e queixa de dor em 42,9% dos pacientes.

Conclusão A escápula alada pode ter diferentes etiologias, dentre elas o osteocondroma retroescapular. O conhecimento sobre anatomia funcional e semiologia ortopédica somado à correta sistematização da abordagem dos tumores ósseos consiste na base para o correto diagnóstico diferencial e tratamento adequado.
Atuação do médico cirurgião de mão em microcirurgia no Brasil
Authors: Endo Rosana Raquel , Fernandes Carlos Henrique , Fernandes Marcela , Santos Joao Baptista Gomes dos , Angelini Luiz Carlos , Nakachima Luis Renato
Published: July 2019

Objetivo Avaliar quais as condições que o cirurgião de mão no Brasil tem encontrado na prática clínica para a realização de procedimentos microvasculares.

Métodos Pesquisa clínica primária prospectiva, observacional, transversal e analítica; realizada no 37° Congresso Brasileiro de Cirurgia de Mão, de 30 de março a 1 de abril de 2017, em Belo Horizonte. Por meio de aplicação de questionário a médicos do Congresso, com 12 perguntas, respostas objetivas, fechadas ou de múltipla escolha; envolveram a região geográfica, o tipo de instituição, se pública e/ou privada, seu treinamento microcirúrgico, tempo de formação, condições técnicas, presença de equipe de retaguarda para urgências e remuneração.

Resultados Um total de 143 médicos foram entrevistados, 65,7% atuavam na região sudeste;13,3% na região nordeste; 11,9% na região sul; 6,3% na região centro-oeste; e 2,8% na região norte. Do total de cirurgiões, 43,4%, atuavam há < 5 anos; 16,8% de 5 a 10 anos; 23,8% de 10 a 20 anos; e 23% há > 20 anos. Do total de cirurgiões, 7,0% não tiveram treinamento em cirurgias microvasculares; 63,6% realizaram treinamento na residência médica, 30,8% em outra instituição, e 7,7%, outro país. Do total de cirurgiões, 5,6% trabalhavam em hospitais públicos, 14,7% em hospitais privados, e 76,9% em ambos. Do total de cirurgiões, 1,8% consideravam adequada a remuneração nas instituições públicas e 5,0% nas instituições privadas; 98,2% consideraram inadequadas as remunerações nas instituições públicas e 95,0% nas instituições privadas.

Conclusão A maioria obteve treinamento em microcirurgia, não fazia reimplantes, considerava a remuneração inadequada, e não dispunha de equipe de sobreaviso. Há escassez e má distribuição de cirurgiões de mão com habilidade microcirúrgica nas emergências e baixo valor de reembolso.
Estudo prospectivo sobre o impacto do uso do selante de fibrina humano livre de agentes estabilizadores de coágulo na artroplastia total de joelho
Authors: Pavão Douglas Mello , Palhares Guilherme Mathias , Albuquerque Rodrigo Satamini Pires e , de Sousa Eduardo Branco , Barretto João Maurício
Published: July 2019

Objetivo O objetivo do presente estudo foi avaliar os resultados do uso tópico intraoperatório do selante de fibrina humano livre de agentes estabilizadores de coágulo em pacientes com osteoartrite (OA) submetidos a artroplastia total de joelho (ATJ), buscando diferenças entre os grupos em relação à perda sanguínea, à necessidade transfusional, ao tempo de internação hospitalar, à percepção de dor, à amplitude de movimento e à incidência de complicações.

Métodos Foram analisados prospectivamente um grupo de intervenção (Selante) com 32 pacientes e um grupo controle (Controle) com 31 pacientes, com OA sintomática dos joelhos, submetidos a ATJ.

Resultados Os resultados foram semelhantes entre os grupos, em relação à perda sanguínea visível no dreno em 24 horas (Controle 276,5 mL ± 46,24 versus Selante 365,9 mL ± 45,73), à perda sanguínea total em 24 horas (Controle 930 mL ± 78 versus Selante 890 mL ± 67) e em 60 horas de pós-operatório (Controle 1.250 mL ± 120 versus Selante 1.190 mL ± 96), à necessidade de hemotransfusão (ocorreu em apenas 1 controle), ao tempo de dias na permanência hospitalar (Controle 5,61 ± 0,50 [n = 31] versus Selante 4,81 ± 0,36), dor pós-operatória e amplitude de movimento. O uso do agente selante de fibrina não se relacionou à ocorrência de complicações da cicatrização de ferida, de infecção ou de trombose venosa profunda.

Conclusão Concluímos que o agente hemostático de fibrina humana não foi eficaz em reduzir o volume de sangramento e a necessidade de hemotransfusão ou em interferir no tempo de internação hospitalar, na percepção de dor e na amplitude de movimento. Seu uso não se relacionou a nenhuma complicação.
Tumor de células gigantes do sacro inoperável: opções terapêuticas e controle da dor
Authors: Viana Eneida de Mattos Brito Oliveira , Batista Katia Torres , Carneiro Junior José Leite
Published: July 2019

O tumor de células gigantes (TCG) do sacro é raro e seu tratamento é complexo, devido à dificuldade para a exerese cirúrgica e a baixa resposta às outras opções terapêuticas. Entre os desafios relacionados a este tumor está o controle do seu crescimento e da dor. No presente trabalho, relatamos um caso de tumor de células gigantes do sacro inoperável, apresentando as opções terapêuticas de embolização e de radioterapia para o controle da dor. Relato do caso: paciente do sexo masculino, admitido aos 39 anos de idade, apresentando dor na região sacral com irradiação para os membros inferiores (MMII), com diagnóstico de TCG do sacro inoperável. Realizou-se embolização, uso de interferon, radioterapia, tratamento da dor com opioides e medicamentos adjuvantes, associados a programa de reabilitação. Descreveu-se o difícil controle do crescimento tumoral e da dor ao longo do seguimento, com desfecho estável após 9 anos.
Lesão do tendão flexor: sutura na região avascular ou vascularizada? Estudo biomecânico e histopatológico em coelhos
Authors: Sardenberg Trajano , Muller Sergio Swain , Coelho Kunie Iabuk Rabello , Varanda Denis , Cortopassi Andrea Christina , Pereira Gilberto José Cação
Published: July 2019

Objetivos Analisar os aspectos mecânicos e histopatológicos da cicatrização do tendão flexor com interesse no local de colocação da sutura, na região vascularizada ou avascular.

Métodos Um total de 83 coelhos foram submetidos à sutura central tipo Kessler na região de tendão vascularizado (grupo TN) e na de tendão avascular (grupo FC). O membro operado foi imobilizado por 3 semanas. Os animais foram sacrificados no período imediato, e a 2, 3 e 6 semanas de pós-operatório. As propriedades mecânicas estudadas foram: carga máxima, tensão na carga máxima, módulo de elasticidade, energia na carga máxima e energia por área. O tendão contralateral foi utilizado como controle. O estudo histopatológico foi descritivo.

Resultados A análise das propriedades mecânicas demonstrou comportamento semelhante em ambos os grupos, com estabilização ou discreto aumento no período imediato com 3 semanas e aumento acentuado com 6 semanas. A histopatologia demonstrou processo de cicatrização semelhante nos grupos TN e FC.

Conclusão A colocação da sutura central na região vascularizada ou fibrocartilaginosa avascular não apresenta diferenças em relação aos aspectos biomecânicos e histopatológicos na cicatrização do tendão flexor profundo dos dedos do pé do coelho.
Estudo anatômico da inervação do músculo supinador para reinervar o nervo interósseo posterior
Authors: Caetano Edie Benedito , Vieira Luiz Angelo , Sabongi Neto João José , Caetano Maurício Ferreira , Sabongi Rodrigo Guerra , Cruz Bruno Azi Pacileo
Published: July 2019

Objetivo O objetivo deste estudo anatômico, foi analisar a possibilidade de transferir os ramos do nervo radial destinados ao músculo supinador para reinervar o nervo interósseo posterior (NIP), que se origina das raízes C7-T1.

Métodos Foram dissecados 30 membros de 15 cadáveres, todos do sexo masculino, preparados por injeção intra-arterial de uma solução de glicerina e formol a 10%.

Resultados Em todos os membros dissecados, encontramos pelo menos um ramo destinado a cada uma das cabeças – superficial e profunda – do músculo supinador. Esses tiveram origem no NIP. Identificamos, proximal à arcada de Frohse, um ramo para o supinador em seis membros; 2 ramos para o supinador em 11 membros e 3 ramos em 4 membros. Em dois membros, apenas um ramo desprendia-se do NIP, mas se duplicava proximalmente à arcada de Frohse. Em sete membros, não identificamos ramos para o supinador proximal à arcada de Frohse. Os ramos destinados ao músculo supinador foram seccionados na junção neuromuscular, podendo ser conectados sem tensão ao NIP. O diâmetro somado dos ramos destinados ao músculo supinador correspondeu, em média, a 53,5% do diâmetro do NIP.

Conclusão Este estudo anatômico mostra que ramos do nervo radial destinados ao músculo supinador podem ser transferidos diretamente para o NIP sem tensão para restaurar a extensão do polegar e dos dedos em pacientes com lesões de plexo braquial C7-T1.
Computerized Physician Order Entry in the Neonatal Intensive Care Unit: A Narrative Review
Authors: York Jaclyn B. , Cardoso Megan Z. , Azuma Dara S. , Beam Kristyn S. , Binney Geoffrey G. , Weingart Saul N.
Published: July 2019

Background Computerized physician order entry (CPOE) has grown since the early 1990s. While many systems serve adult patients, systems for pediatric and neonatal populations have lagged. Adapting adult CPOE systems for pediatric use may require significant modifications to address complexities associated with pediatric care such as daily weight changes and small medication doses.

Objective This article aims to review the neonatal intensive care unit (NICU) CPOE literature to characterize trends in the introduction of this technology and to identify potential areas for further research.

Methods Articles pertaining to NICU CPOE were identified in MEDLINE using MeSH terms “medical order entry systems,” “drug therapy,” “intensive care unit, neonatal,” “infant, newborn,” etc. Two physician reviewers evaluated each article for inclusion and exclusion criteria. Consensus judgments were used to classify the articles into five categories: medication safety, usability/alerts, clinical practice, clinical decision Support (CDS), and implementation. Articles addressing pediatric (nonneonatal) CPOE were included if they were applicable to the NICU setting.

Results Sixty-nine articles were identified using MeSH search criteria. Twenty-two additional articles were identified by hand-searching bibliographies and 6 articles were added after the review process. Fifty-five articles met exclusion criteria, for a final set of 42 articles. Medication safety was the focus of 22 articles, followed by clinical practice (10), CDS (10), implementation (11), and usability/alerts (4). Several addressed more than one category. No study showed a decrease in medication safety post-CPOE implementation. Within clinical practice articles, CPOE implementation showed no effect on blood glucose levels or time to antibiotic administration but showed conflicting results on mortality rates. Implementation studies were largely descriptive of single-hospital experiences.

Conclusion CPOE implementation within the NICU has demonstrated improvement in medication safety, with the most consistent benefit involving a reduction in medication errors and wrong-time administration errors. Additional research is needed to understand the potential limitations of CPOE systems in neonatal intensive care and how CPOE affects mortality.
Risk Factors for 30-Day Readmission following Knee Arthroscopy
Authors: Hartwell Matthew J. , Morgan Allison M. , Johnson Daniel J. , Nicolay Richard W. , Christian Robert A. , Selley Ryan S. , Terry Michael A. , Tjong Vehniah K.
Published: July 2019

This study evaluates knee arthroscopy cases in a national surgical database to identify risk factors associated with readmission. The American College of Surgeons National Surgical Quality Improvement Program database was queried from 2012 to 2016 for billing codes related to knee arthroscopy. International Classification of Diseases diagnostic codes were then used to exclude cases which involved infection. Patients were subsequently reviewed for readmission within 30 days. Univariate and multivariate analyses were then performed to identify risk factors associated with 30-day readmission. A total of 69,022 patients underwent knee arthroscopy. The overall 30-day complication rate was 1.75% and the 30-day readmission rate was 0.92%. On multivariate analysis, age > 60 years (odds ratio [OR], 1.29; 95% confidence interval [CI], 1.07–1.55), smoking (OR, 1.40; 95% CI, 1.15–1.70), recent weight loss (OR, 13.22; 95% CI, 5.03–34.73), chronic obstructive pulmonary disease (OR, 1.98; 95% CI, 1.39–2.82), hypertension (OR, 1.48; 95% CI, 1.23–1.78), diabetes (OR, 1.92; 95% CI, 1.40–2.64), renal failure (OR, 10.65; 95% CI, 2.90–39.07), steroid use within 30 days prior to the procedure (OR, 1.91; 95% CI, 1.24–2.94), American Society of Anesthesiologists (ASA) class ≥ 3 (OR, 1.69; 95% CI, 1.40–2.04), and operative time > 45 minutes (OR, 1.68; 95% CI, 1.42–2.00) were identified as independent risk factors for readmission. These findings confirm that the 30-day overall complication (1.75%) and readmission rates (0.92%) are low for knee arthroscopy procedures; however, age > 60 years, smoking status, recent weight loss, chronic obstructive pulmonary disease, hypertension, diabetes, chronic steroid use, ASA class ≥ 3, and operative time > 45 minutes are independent risk factors for readmission.
Hamstring Anterior Cruciate Ligament Reconstruction Using an Adjustable-Loop Cortical Suspension Device: Immediate Postoperative Magnetic Resonance Imaging
Authors: Choi Nam-Hong , Lee Seung-Joo , Oh Whang-Kyun , Victoroff Brian N.
Published: July 2019

The purpose of this study is to determine whether the hamstring grafts are fully inserted into the femoral tunnel with the adjustable loop using immediate postoperative magnetic resonance imaging (MRI) after anterior cruciate ligament (ACL) reconstructions. A total of 62 consecutive patients underwent hamstring ACL reconstruction using an adjustable-loop cortical suspension device for the femoral fixation and the Intrafix sheath and screw for the tibial fixation. Multiplanar reformatted images of 3-T MRI scans were obtained at the 1st postoperative day before weight bearing is initiated in all patients to evaluate the gap (the tunnel–graft gap) between the top of the hamstring graft and top of the femoral tunnel. Postoperative MRI scans showed that the tunnel–graft gap was 1.5 ± 2.7 mm (range, 0–12 mm). In 43 (69.4%) patients, there was no gap between the top of the femoral tunnel and hamstring graft. In 19 (30.6%) patients, there was a gap between the tunnel and graft, and nine patients demonstrated a tunnel–graft gap greater than 5 mm. Immediate postoperative MRI scans demonstrated that an adjustable-loop cortical suspension device may not pull the hamstring graft completely into the femoral tunnel.
Early Postoperative Pain Predicts 2-Year Functional Outcomes following Knee Arthroplasty
Authors: Lakra Akshay , Murtaugh Taylor , Shah Roshan P. , Cooper H. John , Geller Jeffrey A.
Published: July 2019

Pain control following knee arthroplasty is extremely important to both patients and surgeons to improve the perioperative experience; however, the implication of early pain control on long-term outcomes following knee arthroplasty remains poorly understood. We hypothesized that poor early pain control results in poor functional outcomes 2 years following total (TKA) and unicondylar knee arthroplasty (UKA). This retrospective study reviewed 242 TKA and 162 UKA performed at a single institution by two surgeons. Mean visual analog scale (VAS) pain scores were collected for first 3 postoperative days. Patients were prospectively evaluated using short form (SF-12), the Western Ontario and McMaster University osteoarthritis index (WOMAC), and the Knee Society functional score (KSFS) questionnaires. Pearson's correlation coefficients were calculated between mean VAS pain scores and functional outcome scores at 2 years. In the TKA group, poorly controlled perioperative pain correlated with poorer functional scores at 2 years. There was a significant negative correlation between early mean VAS pain scores (mean, 3.2 ± 2.0) and most 2-year functional outcomes including SF-12 physical score (r = −0.227, p ≤ 0.01), WOMAC pain scores (r = −0.268, p ≤ 0.01), WOMAC stiffness scores (r = −0.224, p < 0.01), WOMAC function score (r = −0.290, p 0.01), and KSFS (r = −0.175, p = 0.031). Better control of early pain was associated with improved functional outcomes at 2 years following TKA. We also found significant negative correlations between preoperative functional scores and early postoperative pain scores. Collectively, using preoperative and early postoperative pain scores, we identified an “at-risk” patient group that manifested an inferior functional outcome at 2 years; these patients may benefit from closer surveillance and a multidisciplinary approach to pain and function to optimize their clinical outcome following knee arthroplasty.
Congenital Genetic Microcephaly: Clinical Diagnostic Approach
Authors: Marino Silvia , Pavone Piero , Marino Lidia , Rapisarda Filippo Andrea Salvatore , Falsaperla Raffaele
Published: July 2019

Microcephaly is an important neurological sign defined by a cranial circumference < 2 standard deviations or < 3 standard deviations in the severe form compared with age- and gender-matched children. Microcephaly is classified as congenital (prenatal) and postnatal. In general, microcephaly may result from an insult, including infections, metabolic diseases, cerebral malformations, and/or genetic syndromes that disturb early brain growth. Clinical history, the trajectory of the child's growth in terms of head circumference, and a detailed physical examination will often be suggestive of a diagnostic workup. Advances in neuroimaging and especially genetics have yielded improvements in understanding the causes of microcephaly, leading to new approaches in diagnosis, treatment, and prevention. The aim of the present study is to report the current practice for the diagnostic algorithm of genetic microcephaly, with prenatal onset.
A versatile induction heating system for magnetic hyperthermia studies under different experimental conditions
Authors: Hadadian Yaser , Azimbagirad Mehran , Navas Elcio A. , Pavan Theo Z.
Published: July 2019

In recent decades, magnetic hyperthermia using magnetic nanoparticles, a promising but quite challenging method, has proven to be an effective cancer therapy procedure. In hyperthermia, heat, which is generated by magnetic nanoparticles exposed to a radiofrequency magnetic field, is employed to battle cancerous cells. Ideally, devices for magnetic hyperthermia should provide a variety of field amplitudes and frequencies for generating an appropriate and powerful alternating magnetic field. Here, we report the design and evaluation of a versatile system which provides different experimental setup possibilities for magnetic hyperthermia. The proposed system is a derivative of the Mazzilli inverter, which directly follows the resonant frequency of the LC tank circuit independent of its component. The feasibility of the system for hyperthermia studies was examined using iron oxide nanoparticles prepared by the coprecipitation method. Different experimental conditions including nanoparticles in solution and dispersed in gelatin phantoms were evaluated. Four different coils including two solenoids, a pancake, and a Helmholtz-like format were successfully tested. Using these coils, 18 different operation frequencies in the frequency band of 63–530 kHz with field strengths up to 27.2 kA/m were achieved.
An autonomous low-power management system for energy harvesting from a miniaturized spherical piezoelectric transducer
Authors: Diab D. , Lefebvre F. , Nassar G. , Smagin N. , Isber S. , El Omar F. , Naja A.
Published: July 2019

A new spherical vibrational energy harvesting device with an additional low power management circuit for optimizing the power transfer from the mechanical vibrations to a storage capacitor is presented. The device is devoted to underwater wireless sensor network applications due to its broadband vibrational energy harvesting, sensing, and communicating facilities. The sensing node container consists of two acrylic glass (PMMA) half-spherical shells and a Pz26 piezoelectric ring clamped between the shells. The energy harvesting, the management circuit, and communication electronics were fitted within the hollow portion of the sphere. A simulation model of the energy extraction and management system using spice has been developed. This simulation shows the feasibility and efficiency of the low power extraction circuit; a level of the necessary stored voltage was set at 3 V. The numerical model was validated by underwater experimental measurements; a voltage of 3 V was obtained at the terminals of a storage capacitor (47 µF) which was sufficient to supply the communication electronics. Power harvesting performances were measured relative to the transmitter/sensor distance and the incident acoustical field excitation voltage. Finally, 175 µW of harvested power has been measured with an excitation voltage of 8 Vpp at 5 cm distance from the emitter.
System identification and experiment evaluation of a piezoelectric-based sting damper in a transonic wind tunnel
Authors: Dai Yuke , Shen Xing , Zhang Lei , Yu Yi , Kou Xiping , Yu Li
Published: July 2019

In wind tunnel tests, a long cantilever sting is usually used to support the test model. However, it is vulnerable to violent oscillation without an effective damping device. In this paper, a piezoelectric-based sting damper designed for solving the vibration problem in wind tunnel tests is detailed, especially its system identification process, which is generally a difficult challenge in practice. Besides, a new hardware platform for various instruments is established and a real-time control software system is built to verify the feasibility and practicability of the whole vibration control process. Furthermore, aiming at measuring the suppression of the first two order’s vibration, the impulse stimulus test as well as the transonic wind tunnel test are carried out to evaluate the capability of the sting damper. The results show the excellent performance of the Zoom-frequency response function algorithm in identifying the damper, based on which suitable parameters of PD controller are acquired and the damping coefficient of the sting increases over 60 times in impulse stimulus. In addition, the superiority of the sting damper in suppressing vibration is proved by the transonic wind tunnel test, in which the maximum testing angle of attack enlarges under different Mach numbers.
From a Kac algebra subfactor to Drinfeld double
Authors: De Sandipan
Published: July 2019

Given a finite-index and finite-depth subfactor, we define the notion of quantum double inclusion—a certain unital inclusion of von Neumann algebras constructed from the given subfactor—which is closely related to that of Ocneanu’s asymptotic inclusion. We show that the quantum double inclusion when applied to the Kac algebra subfactor RH ⊂ R produces Drinfeld double of H, where H is a finite-dimensional Kac algebra acting outerly on the hyperfinite II1 factor R and RH denotes the fixed-point subalgebra. More precisely, quantum double inclusion of RH ⊂ R is isomorphic to R ⊂ R ⋊ D(H)cop for some outer action of D(H)cop on R, where D(H) denotes the Drinfeld double of H.
Effect of wall proximity on the flow over a cube and the implications for the noise emitted
Authors: Wang Yanan , Thompson David , Hu Zhiwei
Published: July 2019

The flow over an object such as a cube and the resulting aerodynamic noise are affected by its proximity to a wall. To evaluate the effect of wall proximity on the aerodynamics induced by a cube, numerical investigations have been performed for the flow past the cube elevated to different heights above a solid surface, using the delayed detached eddy simulation method. A benchmark case of a wall-mounted cube in uniform flow is first studied, which gives commendable agreement with the available measurement results, validating the numerical methodology adopted. Subsequently, the cube is elevated to different heights above the ground. Detailed flow topologies around the cube affected by the elevated height are investigated. In addition, the effect of wall proximity on near-wall flow patterns and distributions of the surface pressure are also analyzed. After examining the flow features, the far-field noise emitted from the cube at different elevated heights is predicted by using the Ffowcs Williams-Hawkings acoustic analogy and some implications of the effect of wall proximity on the emitted noise are summarized. For the wall-mounted cube, the noise is greatest along the lateral direction. As the cube is lifted, the radiated sound in the vertical direction increases rapidly and peaks at one quarter of its side length above the ground. The noise induced by the cube tends to be broadband although broad peaks at a Strouhal number of around 0.1 are observed in the vertical and the lateral directions.
Using phase-space Gaussians to compute the vibrational states of OCHCO+
Authors: Pandey Ankit , Poirier Bill
Published: July 2019

In this article, we use momentum-symmetrized phase-space Gaussians to calculate the vibrational energy eigenstates of the OCHCO+ cation. A potential energy surface provided by Bowman’s group was used, albeit refit to a sixth order anharmonic force field. We have developed the “Crystal” algorithm to implement various basis set truncation strategies for our calculations. These calculations were performed using the SwitchBLADE code, designed by our group, which constructs and diagonalizes the vibrational Hamiltonian matrix in order to compute energy eigenstates. A theoretical overview of the Crystal algorithm is presented, as is a discussion of how best to truncate the basis for a floppy double-well system. Specific vibrational transition frequency results for OCHCO+ are also presented and analyzed.
Transitions in pressure-amorphized clathrate hydrates akin to those of amorphous ices
Authors: Andersson Ove , Brant Carvalho Paulo H. B. , Hsu Ying-Jui , Häussermann Ulrich
Published: July 2019

Type II clathrate hydrates (CHs) were studied by thermal and dielectric measurements. All CHs amorphize, or collapse, on pressurization to 1.3 GPa below 135 K. After heating to 160 K at 1 GPa, the stability of the amorphous states increases in a process similar to the gradual high density to very high density amorphous ice (HDA to VHDA) transition. On a subsequent pressure decrease, the amorphized CHs expand partly irreversibly similar to the gradual VHDA to expanded HDA ice transformation. After further heating at 1 GPa, weak transition features appear near the HDA to low density amorphous ice transition. The results suggest that CH nucleation sites vanish on heating to 160 K at 1 GPa and that a sluggish partial phase-separation process commences on further heating. The collapsed CHs show two glass transitions (GTs), GT1 and GT2. GT1 is weakly pressure-dependent, 12 K GPa−1, with a relaxation time of 0.3 s at 140 K and 1 GPa; it is associated with a weak heat capacity increase of 3.7 J H2O-mol−1 K−1 in a 18 K range and an activation energy of only 38 kJ mol−1 at 1 GPa. The corresponding temperature of GT2 is 159 K at 0.4 GPa with a pressure dependence of 36 K GPa−1; it shows 5.5 times larger heat capacity increase and 4 times higher activation energy than GT1. GT1 is observed also in HDA and VHDA, whereas GT2 occurs just above the crystallization temperature of expanded HDA and only within its ∼0.2–0.7 GPa stable pressure range.
Supramolecular copolymers predominated by alternating order: Theory and application
Authors: van Buel Reinier , Spitzer Daniel , Berac Christian Marijan , van der Schoot Paul , Besenius Pol , Jabbari-Farouji Sara
Published: July 2019

We investigate the copolymerization behavior of a two-component system into quasilinear self-assemblies under conditions that interspecies binding is favored over identical species binding. The theoretical framework is based on a coarse-grained self-assembled Ising model with nearest neighbor interactions. In Ising language, such conditions correspond to the antiferromagnetic case giving rise to copolymers with predominantly alternating configurations. In the strong coupling limit, we show that the maximum fraction of polymerized material and the average length of strictly alternating copolymers depend on the stoichiometric ratio and the activation free energy of the more abundant species. They are substantially reduced when the stoichiometric ratio noticeably differs from unity. Moreover, for stoichiometric ratios close to unity, the copolymerization critical concentration is remarkably lower than the homopolymerization critical concentration of either species. We further analyze the polymerization behavior for a finite and negative coupling constant and characterize the composition of supramolecular copolymers. Our theoretical insights rationalize experimental results of supramolecular polymerization of oppositely charged monomeric species in aqueous solutions.
Effective non-adiabatic Hamiltonians for the quantum nuclear motion over coupled electronic states
Authors: Mátyus Edit , Teufel Stefan
Published: July 2019

The quantum mechanical motion of the atomic nuclei is considered over a single- or a multidimensional subspace of electronic states which is separated by a gap from the rest of the electronic spectrum over the relevant range of nuclear configurations. The electron-nucleus Hamiltonian is block-diagonalized up to O(εn+1) through a unitary transformation of the electronic subspace, and the corresponding nth-order effective Hamiltonian is derived for the quantum nuclear motion. Explicit but general formulas are given for the second- and the third-order corrections. As a special case, the second-order Hamiltonian corresponding to an isolated electronic state is recovered which contains the coordinate-dependent mass-correction terms in the nuclear kinetic energy operator. For a multidimensional, explicitly coupled electronic band, the second-order Hamiltonian contains the usual Born–Oppenheimer terms and nonadiabatic corrections, but generalized mass-correction terms appear as well. These, earlier neglected terms, perturbatively account for the outlying (discrete and continuous) electronic states not included in the explicitly coupled electronic subspace.
Quantum Monte Carlo simulation for the many-body decomposition of the interaction energy and electron correlation of small superalkali lithium clusters
Authors: Brito B. G. A. , Hai G.-Q. , Cândido L.
Published: July 2019

Using the fixed-node diffusion Monte Carlo (FN-DMC) method, we calculate the total energy of small lithium clusters Lin (n = 2–6) to obtain the many-body decomposition of the interaction energy of 2- up to 6-body interactions. The obtained many-body decomposition of the interaction energy shows an alternating series with even and odd terms of attractive and repulsive contributions, respectively. The two-body attractive interactions guarantee the stability of the Li2, Li3, and Li4 clusters. For larger clusters Li5 and Li6, the 4-body attractive interactions are required for their stabilization once the strength of the 3-body repulsive interactions overwhelms that of the 2-body attractive ones. With increasing the cluster size, the additive and nonadditive contributions to the interaction energy increase linearly in magnitude but with different slopes for the two-dimensional (2D) planar and three-dimensional (3D) cagelike clusters. The significant increment in nonadditive effects from the 4-atom to the 5-atom cluster has driven the structural transition from 2D to 3D. Combining the FN-DMC calculations with the Hartree-Fock many-body decomposition of the interaction energy, we extract the correlation effects, showing that an odd-even competition pattern in the many-body repulsive and attractive interactions is crucial for the stabilization of the clusters.
Modeling of interaction induced polarizability of H2-H, numerical analysis
Authors: Głaz Waldemar , Haskopoulos Anastasios , Maroulis George , Bancewicz Tadeusz
Published: July 2019

The main effort in this study is focused on devising a numerical model procedure capable of providing reliable values of collisionally induced microscopic properties of importance in processes of light radiation interactions with molecular media. Special attention is devoted to the anisotropic polarizability of the weakly bound H2-H compounds, although broader applicability of the routines proposed is anticipated as well. To this end, Cartesian components of the collision-induced anisotropic polarizability, Δαij[−], are obtained for the L- (linear, 0°), S- (45°), and T-shape (90°) configurations of the supermolecular systems. The quantum chemistry ab initio numerical method is applied to determine the values of the quantities within the range of the separations between H2 and H moieties reaching 3 < R < 20 bohrs. This approach is then combined with long-range approximate computing routines in order to formulate an overall uniform modeling algorithm including the influence of the exchange, dispersion, and induction interactions on the collisional induced (CI) effects. The validity and precision of the tool is thoroughly assessed. The polarizabilities are then transformed so as to be expressed in terms of the so-called symmetry adapted (SA) components of the spherical tensor representation, ΔαλL(2). Applicability of the modeling scheme is evidenced with regard to the effective evaluation of symmetry adapted parameters for an extended range of intramolecular angularities, separations, and indices. The importance of the procedure for foreseeable CI spectral profile analyses is discussed.
Energy-weighted density matrix embedding of open correlated chemical fragments
Authors: Fertitta Edoardo , Booth George H.
Published: July 2019

We present a multiscale approach to efficiently embed an ab initio correlated chemical fragment described by its energy-weighted density matrices and entangled with a wider mean-field many-electron system. This approach, first presented by Fertitta and Booth [Phys. Rev. B 98, 235132 (2018)], is here extended to account for realistic long-range interactions and broken symmetry states. The scheme allows for a systematically improvable description in the range of correlated fluctuations out of the fragment into the system, via a self-consistent optimization of a coupled auxiliary mean-field system. It is discussed that the method has rigorous limits equivalent to the existing quantum embedding approaches of both dynamical mean-field theory and density matrix embedding theory, to which this method is compared, and the importance of these correlated fluctuations is demonstrated. We derive a self-consistent local energy functional within the scheme and demonstrate the approach for hydrogen rings, where quantitative accuracy is achieved despite only a single atom being explicitly treated.
The magnetization profile induced by the double magnetic proximity effect in an Fe/Fe0.30V0.70 superlattice
Authors: Palonen H. , Mukhamedov B. O. , Ponomareva A. V. , Pálsson G. K. , Abrikosov I. A. , Hjörvarsson B.
Published: July 2019

The double magnetic proximity effect (MPE) in an Fe/Fe0.30V0.70 superlattice is studied by a direct measurement of the magnetization profile using polarized neutron reflectivity. The experimental magnetization profile is shown to qualitatively agree with a profile calculated using density functional theory. The profile is divided into a short range interfacial part and a long range tail. The interfacial part is explained by charge transfer and induced magnetization, while the tail is attributed to the inhomogeneous nature of the FeV alloy. The long range tail in the magnetization persists up to 170% above the intrinsic ordering temperature of the FeV alloy. The observed effects can be used to design systems with a direct exchange coupling between layers over long distances through a network of connected atoms. When combined with the recent advances in tuning and switching, the MPE with electric fields and currents, the results can be applied in spintronic devices.