bluuebunny/crossref_metadata_2025 huggingface dataset:
Cleft lip repair simulation: an Australian trainee experience
Authors: Khoo Rachel , Ryan Emily , Vijayasekaran Vijith , Gillet David A
Published: April 2024

**Background**: Cleft lip repair is technically challenging surgery that requires an appreciation of the complex anatomy of the lip and nose. Effective transference of skill has been demonstrated through the use of simulations. We established a cleft lip and palate simulation workshop to improve training. In this report we assessed the confidence of plastic surgery trainees to perform a cleft lip repair before and after the simulation exercise. **Design**: We purchased 3D high-fidelity simulation models for the workshop. Participants watched a short video depicting cleft lip markings, incisions and repair. Two senior cleft surgeons provided additional commentary and teaching throughout the workshop.**Method**: A 'confidence scale' questionnaire was distributed to 11 plastic surgery trainees. The questionnaire comprised of eight questions on a Likert scale of 1–5 (total score = 40) that prompted a self-assessment of confidence, surgical skill, knowledge and level of 'anxiety' in carrying out a cleft lip repair. Questions about the level of training and prior experience were added to the survey. Participants completed the survey before and after the simulation. **Results**: Comparison of pre and post-simulation surveys showed an average increase of 53.5 per cent in total scores. Improvements were found for all attendees regardless of their level of training or prior experience. **Conclusion**: Simulation training is a validated solution that aids in the acquisition of skills and knowledge. Using simulations in the surgical curriculum has the potential to improve operative learning.
Tocotrienol decreases β-amyloid mediated toxicity in Caenorhabditis elegans model of Alzheimer's disease
Authors: Wah Yuen Chee , Abdul Halim Mardani , Murugaiyah Vikneswaran , Najimudin Nazalan , Azzam Ghows
Published: April 2024

Alzheimer's disease (AD) is a neurological condition that arises from the buildup of senile plaques, which consist of β-amyloid peptide (Aβ), in the brain. The disorder hampers cognitive functions and deteriorates gradually as time passes. The objective of this investigation is to evaluate the efficacy of tocotrienols as a therapeutic intervention for Alzheimer's disease. The study employed a genetically modified Caenorhabditis elegans model that displays paralysis as a result of the activation of the human beta-amyloid Aβ42 gene. This investigation aimed to explore the potential of blended tocotrienols in alleviating paralysis symptoms. Four experiments were conducted to observe the rescuing effect of tocotrienols: paralysis assay, measurement of ROS, immune-dot blot assay, and aggregation assay. The composition of the mixed tocotrienols consisted of 12.1% α-, 2.7% β-, 18.6% γ-, and 8.1% δ-tocotrienols. Treatment with mixed tocotrienols at concentrations of 0.5 %, 0.75 %, and 1 % noticeably prolonged the onset of Aβ-induced paralysis in the genetically modified nematode. Additionally, tocotrienols exhibited antioxidant properties against Aβ-generated oxidative stress, with 0.1% to 1% of mixed tocotrienols demonstrating significantly reduced ROS in the worms. Furthermore, the combination also exhibited strong inhibitory effects on the aggregation of Aβ, demonstrating a potent activity with an IC50 value of 600 ng/ml.
ЛИТЕРАТУРНЫЙ ДИСКУРС, ЕГО РАЗНОВИДНОСТИ И ПУНКТУАЦИЯ
Authors:   БГУ им. К. Карасаева, Козуев Д.И. , Жээнбекова Ч.М. ,   Международный университет Ала-Тоо
Published: April 2024

The article explores the role of punctuation marks in literary fiction discourse, focusing on their impact on text structuring, meaning formation, and the reader's perception of the work. Discourse is defined as a coherent text with ontological and epistemological properties, and the article distinguishes between the usual and occasional use of punctuation marks in a text. The former provides clarity and unambiguity to the work, while the latter is used to achieve special stylistic effects. Punctuation marks are essential in organizing the semantic structure of the text and contribute to meaning-making by setting accents and emphasizing key points. Overall, punctuation plays an important role in encoding and decoding meaning, helping the author express their ideas and intentions while allowing the reader to interpret them correctly.
СЛОВООБРАЗОВАТЕЛЬНЫЕ ВОЗМОЖНОСТИ МОЛОДЕЖНОГО СЛЕНГА (НА ПРИМЕРЕ ШКОЛЬНОЙ И СТУДЕНЧЕСКОЙ АУДИТОРИЙ Г.БИШКЕК)
Authors:   БГУ им. К. Карасаева, Мондошова В.К.
Published: April 2024

The object of the study was youth slang among schoolchildren and students of two universities in Bishkek. Youth slang is a layer of lexical units that reflect the specifics of the functioning of one of the levels of the Russian language. The article presents some aspects of the emergence of the concept of slang and changes in its meaning, focusing on the word-formation possibilities of youth slang. The author considers various ways of forming words in Russian youth slang. The paper attempts to identify and reveal the possibilities of slang to reflect and reproduce the patterns of functioning of the native language.
ТҮРК ЖАЗУУЧУСУ ОРХОН ПАМУКТУН РОМАНДАРЫНДАГЫ ТЕМАТИКАЛЫК ӨЗГӨЧӨЛҮК
Authors:   БГУ им. К. Карасаева, Мусаева Ж.К.
Published: April 2024

Literature bridges cultures, unveiling traditions and customs across the globe. The novels of Orhan Pamuk, a prominent Turkish author, transcend linguistic barriers, offering insights into Turkish literature. Pamuk, renowned for his mastery of the novel genre, is among many accomplished Turkish novelists like Reshat Nuri Guntekin, Khalid Oedipus Adyvar, Aka Gunduz, Peyami Safa, Yashar Kemal, Orhan Kemal, Tarik Bugra, and Adalet Agaolu. Post-1980s writers like Ahmet Altan, Ahmet Yurdakul, Latif Tekin, and Nobel laureate Orkhon Pamuk have further enriched Turkish literature. This article delves into the life and work of a writer, exploring their themes and contributions.
ОБРЯД ПОСВЯЩЕНИЯ ЖИВОТНОГО СВЯЩЕННЫМ ГОРАМ «ЫЙЫК» В АЛТАЙСКО-КЫРГЫЗСКОЙ ТРАДИЦИИ
Authors:   КНУ им.Ж.Баласагына, Абакиров К. , Мурзахмедова Г.М. ,   БГУ имени К. Карасаева, Наева А.И. ,   Республиканский Центр народного творчества Республики Алтай, Горно-Алтайск, Россия
Published: April 2024

The article analyzes the ritual folklore of the Turkic-Mongolian peoples related to the ancient ritual of dedicating an animal to sacred places. With an integrated approach to the main characteristics of this ritual, the role of folklore genres is considered, while the structure of the ritual itself is clarified using the material of Altai folklore in comparison with existing examples from the traditions of the Turkic-Mongolian peoples, including Kyrgyz ritual practices.The study of this issue seems relevant based on the material of Altai ritual folklore from the point of view of their comparative analysis with the ritual materials of the Turkic-Mongolian peoples.
КОНЦЕПТ КАК ИНТЕРПРЕТАТОР СМЫСЛОВ
Authors:   БГУ им. К. Карасаева, Сейтказиева Ж.З.
Published: April 2024

The article considers the concept as a category that unites fundamental knowledge about the world and plays an important role in understanding the world, thinking, and communication. The existing approaches to its definition are described. Two main approaches are distinguished: the cultural approach proposed by Y.S. Stepanov, which considers the concept as a culturally specific way of organizing knowledge and experience, reflecting the values, beliefs, and assumptions of a particular society, and the semantic approach developed in the school of Arutyunova N.D., where concepts are understood as units of cognitive semantics, closely related to the meanings of words and word combinations.
A comparative analysis of anti-seizure drugs consumption released for free or with a discount
Authors: Ustinova Lyudmila P. , Filina Irina A.
Published: April 2024

Aim – to conduct a comparative analysis of the structure of consumption of anti-seizure drugs dispensed free of charge or at a discount for the period of 2017-2021 at the regional level.
Material and methods. The data was collected from the works of domestic and foreign scientists in the field of preferential drug provision, as well as regulatory and organizational documentation on pharmaceutical activities. Preferential prescriptions issued for the period from 2017 to 2021 in the Orel region were analyzed. The ATC/DDD methodology was used to estimate the consumption.
Results. It was revealed that preferential anti-seizure drugs were mainly taken by people aged 40-64 years. In 2017-2018, the consumption of anticonvulsants was higher in women. In 2019-2021, the consumption level was higher in men. Most of the anti-seizure drugs consumers were federal beneficiaries, usually disabled people of group II. The highest value of consumption among the top 5 INNs of antiepileptic drugs during the study period was observed for phenobarbital. The drugs containing valproic acid, topiramate and carbamazepine were characterized by increasing consumption throughout the study period. For benzobarbital, a pattern of consumption stability was revealed.
Conclusion. The ATC/DDD analysis of the consumption structure for anti-seizure drugs within the program of subsidized drug provision for the population made it possible to identify the objective data on the dynamics of consumption for various generations. In order to reduce the consumption of drugs with an unfavorable safety profile, it is necessary to conduct training seminars for doctors of the relevant profile.
arquivo materno revisitado
Authors: Pinto André de Souza
Published: April 2024

Este artigo teve como objetivo analisar, em O que os cegos estão sonhando?: com o diário de Lili Jaffe (1994-1995), de Noemi Jaffe,a imagem do diário materno como um arquivo judaico, uma narrativa que, em sua primeira parte, se configuraria como um texto da literatura de testemunho, que é, por sua vez,desdobrado por Jaffee por Leda Cartum. Assim, buscou-se entrever, na história pessoal que é narrada no diário e nos paratextos que constituiriam o livro, a biografia de Lili Jaffe e as consequências da história materna em sua família.Assim, o principal intento desse artigo foi, a partir desse arquivo biográfico,apresentar a história de Lili Jaffe e como o seu diário institui um depósito de narrativas que são desdobradas na contemporaneidade.
Survey and evaluation of Olive Leaf Spot caused by Venturia oleaginea (Castagne) Rossman & Crous (2015) on olive trees in Algeria
Authors: Kheddam Benadjal Nadia , Benzehra Abdelmajid , Kheddam Mohamed , Bouznad Zouaoui
Published: April 2024

Objective: Olive Leaf Spot fungal disease caused by Venturia oleaginea (Castagne) Rossman & Crous (2015). It has a significant negative impact on certain olive growing regions of Algeria. Methodology and results: A survey was conducted from 2013 to 2015 during periods at risk of contamination (i.e. autumn, winter and early spring) to map the geographical distribution of this pathogen. The results obtained showed that Olive Leaf Spot is present in all olive- growing regions in Algeria but not in all states. Twenty seven (27) states out of the 35 surveyed states were reported to be infested, with a total of 1163 infected orchards out of the 1696 orchards surveyed, and a percentage of infection also varying from one region to another and depending on the year. The results of the statistical analyses based on Tukey HSD test at P<0.05 show very highly significant differences between the Wilayas affected. The western regions are very highly significant, whereas in the east the infection is less important. This difference may be explained by the more favourable climatic conditions, the dominance of a single olive variety “Sigoise” which seems to be more susceptible to the disease and the lack of a technical itinerary. Conclusion and application of results: This survey is the first on the situation of olive leaf spot in the olive growing regions located in the East, West and Center of the country, allowing to map the distribution of this pathogen, and the use of resistant varieties as biological control agents in the treatment of OLS disease in Algeria. Keywords: Infected, Venturia oleaginea, Olive Leaf Spot, survey, variety.
Aplikasi Layanan dan Informasi Akademik Berbasis Chatbot Telegram Menggunakan Natural Language Processing
Authors: Qalimaturrahmah Maulida , Santoso Dwi Budi
Published: April 2024

Dalam era digital, kemajuan teknologi merubah berbagai aspek kehidupan. Salah satu kemajuan teknologi yang signifikan adalah teknologi Chatbot. Pada dunia Pendidikan tinggi, permasalahan yang sering dialami mahasiswa saat ini adalah kurangnya literasi terhadap informasi penting yang tersedia di website fakultas, karena tidak semua mahasiswa selalu mengakses website. Dengan teknologi Chatbot berbasis Natural Language Processing menggunakan framework Rasa yang diintegrasikan dalam platform telegram, akan memudahkan mahasiswa mendapatkan informasi lebih cepat dan efisien. Metode pembuatan Chatbot ini dengan studi literatur, pengumpulan data, data pre-processing, framework Rasa, implementasi, pengujian system, dan hasil. Data yang dipakai dalam pembuatan Chatbot diambil dari informasi yang terdapat didalam website fakultas. Modifikasi file Framework Rasa dengan total 47 intent dan 394 exemples, proses training dan testing dilakukan melalui command prompt, dan integrasi Chatbot ke telegram melalui visual studio code. Dari hasil pengujian, Chatbot yang telah diintegrasikan ke telegram dapat digunakan dengan baik, response yang diberikan Chatbot tepat.
Aplikasi Laporan Berita Jurnalis Pada Surat Kabar Harian Sumut Pos Medan Menggunakan Kodular
Authors: Alda Muhamad , Sweety Miana , Rayhannur M Jaffar , Toar Miftahul Jannah
Published: April 2024

Various new print media have emerged in Indonesia with the same aim of providing complete information to the public. Current technology makes it easy for the journalism sector to use it as a means of conveying news information easily. Journalists as news content producers. Recording each member's journalistic activities is one of the journalist's duties in making news. Journalistic activity records are one of the main materials in consideration for making news. There are several stages of the waterfall model, namely: Requirements analysis, system design, coding, application testing, program implementation. The purpose of data analysis is to make it easier to design information in a system. There is some data used in creating an information system for journalists' daily reports in the North Sumatra Post daily newspaper, such as data analysis. This application can also make it easier for the North Sumatra Medan Post Office to monitor and manage journalists' news data. Equipped with a login application, security can be guaranteed from use by unauthorized people
Audit committee attributes, audit quality and performance of oil and gas companies
Authors: Bako Paul Matudi
Published: April 2024

Purpose: This study examines the audit committee attributes, audit quality, and financial performance of listed oil and gas companies in Nigeria.
Research methodology: Audit committee attributes were measured by audit committee size, audit committee independence, and audit committee financial expertise, and audit quality was measured by audit fees charged by an external auditor. Financial performance is measured in terms of earnings per share. The researcher used secondary data extracted from the ten listed oil and gas firms annual reports, and the accounts were analyzed using Panel Least Square.
Results: This study reveals a positive and statistically significant relationship between audit committee independence and earnings per share. It also shows that audit quality moderates audit committee attributes significantly and increases firm performance. This study recommends that maintaining high audit quality within the audit committee is crucial for a firm if it aims to offer increased assurance to investors and stakeholders concerning the precision and dependability of its financial statements.
Limitations: This study was limited to listed oil and gas companies in Nigeria ranging from to 2016-2022.  
Contribution:  This study examined factors that can moderate the relationship between audit committees and the financial performance of listed oil and gas companies in Nigeria. One such factor is audit quality, which can potentially enhance or diminish the impact of audit committee effectiveness on financial performance. No study conducted in Nigeria has examined this relationship specifically in the oil and gas sector. This knowledge gap served as the rationale for conducting this study.
Bridging the agriculture-health gap for improved farm productivity and efficiency: A review
Authors: Echebiri R. N. , Nwogu D.C. , Apu U. , Ugboaja I. C.
Published: April 2024

The thrust of this paper is that there exists a bi-directional causal relationship between agriculture and health, such that agriculture influences health, and vice-versa. On the basis of this bidirectional link, it becomes quite imperative that health-agriculture issues should be integrated at some levels, especially in rural development planning where agriculture and primary healthcare ought to be at the forefront of policy formulation. It is also important to understand this relationship properly in order to see how certain variables in farm economics may be reviewed further for more empirical relevance. To achieve these cardinal objectives, the paper takes on a general but brief review of status to highlight the interconnections of health and agriculture. It further draws parallels from some empirical evidences of effects of illnesses and labour losses arising from malaria and HIV/AIDs across different climes including the burden of care giving and resort to child labour as a labour compensation strategy. Based on these, some policy and empirical interventions are put forward to strengthen the bi-directional health-agriculture synergies and improved research in farm economics.
Response of okra (Abelmoschus esculentus (L.) Moench) and soil chemical properties to different amendment types in an ultisol
Authors: Ogbemudia I. , Kido S. , Edosa V. I.O. , Imasuen E.E. , Ogboghodo I. A.
Published: April 2024

A field experiment was carried out to investigate the effect of different organic manure on the growth and yield of okra (Abelmoschus esculentus (L.) Moench) at the teaching and research farm of the University of Benin, Benin City, Edo State, Nigeria between April to August, 2016. Four treatments; control (T1), cattle dung + poultry manure + pig manure (T2), poultry manure + foliar blend (T3) and bacterial inoculant (T4) were laid out in a randomized complete block design with four replications. Data were collected on growth (plant height, number of leaves, stem girth and leaf area) and yield parameters of okra plant. Results obtained from the research indicated that the growth and yield of okra was lowest in control (T1). These results further suggest that, the organic manure used in the study especially in a combined form (cattle dung + poultry manure + pig manure) positively influenced the agronomic performance of the okra plant. T2 increased okra plant height and, leaf area compared with the control. T3 recorded significantly higher number of leaves (7.188), compared with the control (3.375) whereas, fresh fruit weight from the various treatment plots were in the following order; T2 (79.15g) > T3 (53.58g) > T4 (22.53g) > T1 (20.24g). Although the nitrogen content of the soil was higher (21.33 g/kg) with T4, the highest fruit weight was obtained in T2 treated soils. It was also observed from the microbial analysis carried out on the soil samples obtained from the various plots that, soils with organic amendments (T2, T3 and T4) generally had higher microbial population, relative to control (T1). Based on the findings of this experiment, it could be deduced that cattle dung, poultry manure and pig manure promotes higher performance of okra.
Marketing analysis of snails in selected snail markets in Ibadan, Nigeria
Authors: Okeleke S.O.
Published: April 2024

The study was carried out investigate marketing of snails in selected snail markets in Ibadan, Nigeria. Information was collected with the use of structured questionnaires and oral interview. Descriptive statistics such as frequency and percentage and regression were applied to analyze the socio-economic variables. For the regression analysis, linear function had F-ratio that was significant and highest co-efficient of multiple determination (R2) values of 0.971. The study revealed that more females (92.5%) than males (7.5%) were involved in snail marketing in the study area. Majority of the respondents (80.0%) were married while 46.2% were within age bracket of 50-59 years. The result further revealed that 82.5% sourced for capita through personal savings. Per annum profit of N 340,200.00/marketer indicates the profitability of sales. Marketing constraints facing the snail marketers in the study area are price fluctuation, inadequate credit facilities irregular supply and snail mortality. Enhancement of snail marketing can be through cooperative group formation to access credit facilities and good road network provision by government to convey product to market
Effect of vermicomposts on vegetative growth and yield characters of tomato infected with fusarium wilt
Authors: Haruna S.G.
Published: April 2024

In vivo experiment was conducted in the screen house of the Federal College of Horticultural Technology Dadin Kowa, Gombe State. The objective of the studies was to evaluate the bio-efficacy of bio-enriched vermicomposts on seedling growth and yield of tomato infected with Fusarium oxysporum f. sp. lycopersici. A 2 x 5 factorial experiment consisted of Two tomato varieties (Roma VF and UC 82B), three bio-enriched vermicomposts: - poultry manure based – (POBCO), cow dung based – (COBCO) and rice bran based – (RIBCO); CAMAZEB® as check and un-amended soil (UNASO) as control were laid in a randomised complete block design. Three and a half kilograms (3.5 kg) of sterile top-soil was amended with 900 g of POBCO, COBCO, RIBCO and un-amended soils (UNASO) were placed in plastic pots. The treatments (10) were replicated three times. Results on the growth parameters and yield components were significantly higher on Roma VF than UC 82B. Roma VF grown on soil amended with POBCO significantly produced plants with the highest number of leaves (200) and branches (18); and tallest plants (77.5 cm), compared to the other treatments. Highest yield (2.1 kg plant-1), fresh shoot (343.1 g) and fresh root (84.7 g) weights were recorded on Roma VF transplanted in POBCO-amended soils. Application of 900 g of POBCO as soil amendment on Roma VF is recommended as sustainable source of fertilizer for tomatoes under green house or screen house conditions.
Comparison between Home-Based Exercise and Hospital-Based Supervised Exercise in the Early Rehabilitation of Stroke Patients
Authors: Nag Palash , Ripon Shahadath Hossain , Islam Jahidul , Baral Aparajeya Bibav Bikash , Alam MD. Aminul , Hossain Uzzal , Refat Md. Tanzim Hasan , Dey Parag
Published: April 2024

Introduction: Stroke is one of the leading causes of death and disability worldwide and more so in underdeveloped countries like Bangladesh, where health support systems including rehabilitation not expectedly available. Early initiation of rehabilitation procedures can enable a greater return of neurological function and improve long-term outcomes and quality of life. In this study, we aimed to compare the effects of home-based exercise and hospital-based supervised exercise in the early rehabilitation of stroke patients. Methods: This was a prospective observational study and was conducted in the Department of Physical Medicine and Rehabilitation, Dhaka Medical College Hospital, Dhaka, Bangladesh during the period from January, 2014 to June, 2014. In our study, we included 250 patients, and the patients were divided into two groups – Group A (Patients who got home-based exercise) and Group B (Patients who got hospital-based exercise). Result: We found the mean age of the patients of Group A & Group B was 56.75± 9.45 and 55.46± 10.58 years respectively. Among the patients, 41% were female,59% were male and 168 (67.2%) patients had been suffering from ischemic stroke and 82 (32.8%) patients from hemorrhagic stroke. The most common risk factors were HTN, dyslipidemia, and obesity. Mean FIM gain in Group A was 37.97 ± 17.52 and in Group B was 48.56 ± 21.22 which was significantly higher than that of Group A patients. Conclusion: In our study, we found that hospital-based supervised exercise is superior to home-based exercise within 4 weeks of stroke in early rehabilitation of stroke patients.
Artikel Review : Peranan Apoteker Dalam Pelayanan Kefarmasian Pada Pasien Diabetes Melitus (DM)
Authors: Arsita Setyani Endang Tri , Anggraini Dini , Aulia Rivana Ardyanti , Mukti Asri Wido
Published: April 2024

Latar belakang : Pharmaceutical care merujuk pada aktivitas yang dilakukan oleh tenaga kesehatan (terutama apoteker) dalam melakukan komunikasi guna meningkatkan kesehatan, keberhasilan terapi, pencegahan penyakit, atau komplikasi dengan tujuan memastikan pengobatan yang aman dan efektif. Diabetes mellitus adalah suatu kondisi medis yang bersifat kronis yang ditandai dengan adanya peningkatan kadar gula darah dalam jangka waktu yang lama. Kondisi ini terjadi ketika tubuh tidak mampu menghasilkan insulin yang cukup atau tidak mampu memanfaatkan insulin dengan efektif. Insulin adalah hormon yang berperan penting dalam mengatur kadar gula darah dan memungkinkan sel-sel untuk menggunakan glukosa sebagai sumber energi. Tujuan : Review artikel ini bertujuan mengetahui peran apoteker pada pasien diabetes melitus beserta hasil intervensi yang dilakukannya. Review artikel ini merupakan literatur review dari berbagai penelitian yang berkaitan dengan peranan apoteker melaksanakan program pharmaceutical care pada pasien diabetes melitus. Karena apoteker terlibat dalam berbagai kegiatan seperti konseling maka perlu dilakukan penelitian ini untuk menjamin keberhasilan terapi pasien. Beberapa literatur yang dianggap penting dan berkaitan dengan topik tulisan dirangkum dan dianalisis secara kualitatif kemudian dibuat kesimpulan dan hasil analisis yang dilakukan. Metode : Tulisan ini adalah hasil tinjauan literatur yang mengkombinasikan berbagai studi yang mengkaji peran apoteker dalam melaksanakan program Perawatan Farmasi (Pharmaceutical Care) bagi pasien diabetes. Pencarian literatur dilakukan dengan menggunakan kata kunci "kepatuhan pasien diabetes" dan "asuhan kefarmasian" dalam format PDF dari tahun 2013 hingga 2023. Hasil : Terdapat 17 referensi literatur yang relevan mengenai peran apoteker dalam meningkatkan efektivitas pengobatan pada pasien diabetes mellitus. Sampel yang diambil termasuk pasien diabetes mellitus tanpa penyakit penyerta maupun dengan penyakit penyerta. Intervensi yang dilakukan oleh apoteker dalam penelitian ini meliputi konseling, penyesuaian obat, layanan perawatan di rumah, penggunaan kuesioner untuk mengukur kepatuhan, konseling telepon singkat, dan penggunaan kotak pil untuk memantau terapi. Kesimpulan : hasil yang diperoleh mencakup pengendalian kadar gula darah pasien, penurunan faktor risiko, peningkatan kepatuhan minum obat, dan peningkatan kualitas hidup pasien.
Revisão Literária do Atendimento Médico à Comunidade LGBTQIAP+: Desafios e Perspectivas
Authors: Pinto Missioneiro Carlos Henrique , Fagundes Miranda Pedro Paulo , Valério Darcis João Vinícius , Hilsdorf Barbanti Samuel
Published: April 2024

O estudo apresentado na pesquisa aborda a implementação e os desafios de políticas públicas de saúde destinadas à população LGBTQIAP+, um tema considerado urgente e de alta relevância. A criação da Política Nacional de Saúde Integral de Lésbicas, Gays, Bissexuais, Travestis e Transexuais (LGBT) representou um avanço significativo na luta pela igualdade no Brasil. No entanto, a falta de estudos e de dados específicos pode dificultar o desenvolvimento de estratégias efetivas para atender às necessidades de saúde dessa população. Estudos apontam que a discriminação por orientação sexual está associada a resultados adversos à saúde, incluindo violência e estressores psicossociais. A pesquisa realizou uma revisão da literatura da produção científica sobre o tema entre os anos 2018 e 2022, indexados nas bases Scielo, PubMed e Lilacs e utilizando descritores em ciências da saúde: “LGBT” or “gay” or “lesbian” or “transgender persons” or “homosexuality” or “bisexuality” or “sexual and gender minorities” or “gender identity” or “transsexualism”. Os resultados indicaram diversos obstáculos para a implementação de políticas públicas voltadas para a população LGBTQIAP+ no Brasil, incluindo a falta de leis de proteção de direitos, comunicação ineficaz entre o Estado e a sociedade civil, falta de alocação orçamentária para planos e programas e ausência de representação política da comunidade LGBTQIAP+.             Em um momento de avanço de forças conservadoras e de desmonte de direitos, é crucial enfrentar os desafios atuais para a construção do cuidado integral em saúde, levando em consideração a diversidade sexual e de gênero e a equidade em saúde perante a constituição.
Analisa dan Perancangan Optimasi Jaringan dengan Metode Wireles Distribution System
Authors: Rohmanto Sidik , Bahri Saiful , Sanjaya Wisnu
Published: April 2024

designing an internet network that utilizes wireless lines to expand the network area coverage that is able to cover the entire area of ​​the Walen Village Office building is the goal of the research. The internet network design that the researcher uses is a network design with a WDS wireless distribution system model. The results of the design of the internet network with the WDS (Wireless distribution system) model will be tested for 7 days with 3 tests every day, namely 07.00-08.00 "morning", 12.00-13.00 "noon", 16.00-17.00 "afternoon". Network testing is carried out with the aim of finding the QoS (Quality of Service) value of the network that the researcher has implemented at the Walen Village government office, Simo District, Boyolali Regency, the testing procedure that the researcher does is by observing the network during testing with the help of the "wireshark" application. The test results showed that the total average of all the parameters tested during the observation showed satisfactory results with an index value of 3.3 in the satisfactory category.
Comprehensive science mapping of STEM studies in gifted education
Authors: Gül M. Davut , Ayık Zekai
Published: April 2024

The integration of gifted learners into STEM education has raised two key issues: providing suitable learning experiences for them and utilising their potential to contribute to the ultimate goals of STEM education. Hence, research in this area is essential for both researchers and practitioners in gifted education. The purpose of this study was to examine pertinent trends in recent years as revealed by the bibliometric analysis of published studies on STEM in gifted education. A total of 170 publications on gifted and STEM education obtained from Web of Science and Scopus databases were examined. The PRISMA model was used for data collection. RStudio was employed for data analysis. The results of the study revealed that 59 different journals, 170 articles, and 332 authors had contributed to the field of STEM in gifted education. The most frequently used keywords in research in both databases were “STEM”, “gifted students”, “gifted education”, and “talent development”. The most productive journals on STEM-related studies in gifted education were Rooper Review and Gifted Child Quarterly. The most relevant authors were C. June Maker and Paula Olszewski-Kubilius. The most productive institutions were the Northwestern University and the University of North Texas.  Trending topics have evolved from gender differences to enrichment and science mathematically focused subjects, and then technology and engineering focused stem and talent development.
INTERNATIONAL MARITIME SHIPPING, THROUGH THE LENS OF CUSTOMS FRAUD AND SMUGGLING
Authors: R Bakalova
Published: April 2024

When people and companies import goods, they often have to pay a tax or tariff called a duty or import duty. The customs system relies on importers to accurately report the type, value and country of origin of the goods they import and to pay the correct import duties. However unscrupulous importers find many ways to cheat the customs authorities and gain an advantage over their competitors.
KEYWORDS: Tax, Tariff, Import Duty, Customs Authorities, Maritime Shipping
PERCEIVED PROFESSIONAL DEVELOPMENT NEEDS AND EMOTIONAL INTELLIGENCE AS PREDICTORS OF MATHEMATICS TEACHING ANXIETY AMONG MATHEMATICS PRE-SERVICE TEACHERS
Authors: Tom Paulie M. Tongol
Published: April 2024

The primary purpose of this study was to determine whether perceived professional development needs and emotional intelligence predicts mathematics teaching anxiety among mathematics pre-service teacher. This study employed descriptive and correlational designs. Using the stratified random sampling, 103 mathematics pre-service teachers were selected as participants from Davao del Nortes seven higher education institutions during the school year 2021–2022. Moreover, this study utilized three adapted and validated survey questionnaires to gather data, which were treated using mean, Pearson-r, and regression analysis. The findings suggested that pre-service teachers perceived professional development needs are highly addressed, and emotional intelligence is manifested most of the time. Furthermore, the mathematics teaching anxiety of mathematics pre-service teachers is less evident. Findings also revealed that both perceived professional development needs and emotional intelligence exhibit a significant negative correlation with mathematics teaching anxiety. In addition, only perceived professional development needs to predict mathematics teaching anxiety among mathematics pre-service teachers. Future researchers may consider the studys findings which may help them uncover other factors that might improve the conduct of perceived professional development needs and emotional intelligence in relation to mathematics teaching anxiety among mathematics pre-service teachers. With these, teachers and school administrators are encouraged to address professional development needs and assess and boost emotional intelligence to help eliminate mathematics teaching anxiety among mathematics pre-service teachers.
KEYWORDS: mathematics education, perceived professional development needs, emotional intelligence, mathematics teaching anxiety, pre-service teachers, descriptive and correlational designs, regression analysis, Philippines
DETOURS AND DELAYS: NAVIGATING THE PANDEMIC'S IMPACT ON INDIA'S TRANSPORT SECTOR AND TOURISM
Authors: Daggupati Ramanjulu
Published: April 2024

The COVID-19 pandemic has had a profound impact on the Indian transport industry, affecting various sectors such as aviation, railways, road transport, and maritime. The nationwide lockdowns and travel restrictions imposed to curb the spread of the virus led to a significant decline in passenger traffic and freight movement, causing severe financial distress to the industry. This almost standstill in the movement of the people severely affected the Indian tourism industry which provides 7 per cent of GDP and 9 per cent of employment by 2019.
The aviation sector witnessed a sharp decline in passenger traffic, leading to financial losses for airlines and airports. Many airlines were forced to suspend operations or reduce their workforce to survive. Similarly, the Indian Railways faced challenges due to the suspension of passenger trains, impacting revenue generation.
The road transport sector also suffered due to the lockdowns, with restrictions on inter-state and intra-state movement affecting the movement of goods and passengers. The maritime sector faced challenges due to disruptions in global trade and port operations.
To mitigate the impact of the pandemic, the Indian government announced various relief measures, including financial assistance, waivers, and restructuring of loans for the transport industry. The government also launched initiatives such as the Vande Bharat Mission to repatriate stranded Indians and the One Nation, One Card scheme for seamless travel across different modes of transport.
By recognising the importance of the revival of tourism in India Indian Government announced many sops and reliefs to the tour operators, travel agents and transport organisations. Despite these measures, the road to recovery for the Indian transport industry remains challenging. The industry will need to adapt to the new normal by implementing safety measures, embracing digital technologies, and diversifying its operations to ensure resilience in future crises.
KEYWORDS: Covid -19, Road transport, Railways, Civil aviation, Tourism
A STUDY ON THE DETERMINANTS OF EMPLOYEES’ LOYALTY
Authors: Dr. Harsandaldeep Kaur  , Manjot Kaur
Published: April 2024

A human being is a basic asset for making or development of anything. Each organisation need is to have talented and equipped individuals to make their organisation skilful and best. Workers retention is very important for the company. The workers can be retained by building employees loyalty among them. loyalty is portrayed by the expectation to engage with the company in the long term, which assumes a positive job in the maintenance of individuals in the association. So, employees loyalty can be proved very beneficial for the employees as well as the organisation. This study will highlight the factors influencing employees loyalty. Confirmatory factor analysis has been conducted through SMART PLS to determine the factors. It was found that four factors Employees treatment, Job characteristics and satisfaction, Management leadership and Training and Development impacted the employees loyalty the most in the banking sector.
KEYWORDS: Employees loyalty, Employees treatment, Job characteristics and satisfaction, Management leadership, Training and Development
GIS TOOLS IN THE CONSERVATION AND SUSTAINABLE DEVELOPMENT NATIONAL PARKS, FORESTS AND RURAL AREAS
Authors:   Department of Integrated Geodesy and Cartography, AGH University of Krakow, Krakow, Poland, KRZANOWSKI Bartłomiej , KUŁAGA Szymon ,   Department of Integrated Geodesy and Cartography, AGH University of Krakow, Krakow, Poland, BASISTA Izabela ,   Department of Integrated Geodesy and Cartography, AGH University of Krakow, Krakow, Poland, BOROWSKI Łukasz ,   Faculty of Forestry, University of Agriculture in Krakow, Krakow, Poland
Published: April 2024

The problem of optimising the location of crops/plots in protected areas, national parks, farmland or forests involves trying to reconcile their proper functioning with nature conservation, the preservation of unique ecosystems or sustainable development. Such areas are crucial for the preservation of biodiversity and wildlife. This paper examines and discusses the impact of land consolidation in rural areas using GIS (Geographic Information System) tools. It performs a series of network analyses to determine the real distances (following the road network) and linear distances (rectilinear distances) between habitats and farmland. A tool was also developed to automate this process. The results obtained were visualised using map compositions, tables and graphs. The implemented project had a significant beneficial effect on the change in the land structure in the analysed village. The number of registered plots decreased by 40% (from 1,189 to 711) due to the consolidation process.
THE MEMORY OF IASI MONUMENTS RESTORED AFTER 1989: ELEMENTS OF URBAN SOCIOLOGY AND RESTORATION
Authors:   “Alexandru Ioan Cuza” University, Faculty of Orthodox Theology, Closca Street, Iasi, Romania, LĂZĂREANU Carmen-Gabriela , LEONTIE Vlad ,   “Alexandru Ioan Cuza” University Doctoral School of Economics and Business Administration 700057 Iași, Romania
Published: April 2024

The monuments of Iasi, from the perspective of urban sociology, are part of the social life, with human interactions, specific to congested urban areas. From the viewpoint of this discipline, the structures, changes, and problems of the Iași urban community provide elements for the planning and elaboration of urban conservation policies and the restoration of several monuments. In this sense, urban sociology uses a variety of analytical tools such as sociological observation, social theory, interviews, as well as other methods and techniques for the study of specific subjects, such as the relationships between individuals in the urban socialization process, demographic and economic trends, poverty, the effects of urbanization with all the negative aspects regarding the destruction of some monuments on feelings of social alienation and anonymity (elements studied in the Chicago School by Max Weber and George Simmel). The purpose of this paper is precisely to capture the feelings and their perception by the subjects investigated in this study.
REVISITING GLOBAL ENDEMISM PATTERNS OF TERRESTRIAL VERTEBRATES AND THEIR ENVIRONMENTAL PREDICTORS: PUTTING THE FOCUS ON SPECIES RANGE-RESTRICTIONS AT FINE SPATIAL GRAINS
Authors:   Instituto Argentino de Investigaciones de las Zonas Áridas, CONICET, Parque Gral. San Martín s/n,
5500 Mendoza, Argentina, CARRARA Rodolfo
Published: April 2024

Global endemism assessments at fine spatial grains can offer many information about the endemic species richness that inhabit an area, but unable to provide insights on to what extent species distribution ranges are restricted to that area. This inability to account for species range-restrictions prevents recognizing the level of species uniqueness to particular sites, which is necessary to both understand the processes involved in the maintenance of endemism patterns and effectively conserve worldwide biodiversity. To circumvent this problem, the research proposes to use an index capable of measuring the proportion of species restricted to small spatial units. Using species range maps of terrestrial vertebrates, it was assessed global endemism patterns based on species range-restrictions as a counter position to the common use of species richness. Furthermore, it has been evaluated the role that different environmental variables have as predictors of these patterns through simultaneous autoregressive regression. Results showed the highest reported congruence among vertebrate endemism patterns, which suggest the influence of similar processes that affect species range-restrictions through space. Environmental variables explained more than 68% of the total variance on vertebrate endemism, so it is discussed their role as factors that promote species range-restrictions by limiting organism geographic distributions.
Rational drug design from phosphatidylinositol 3-kinase-α inhibitors through molecular docking and 3D-QSAR methodologies for cancer immunotherapy
Authors: Tochukwu Dibia Kevin , Nneka Van-Dibia Sandra , Kanwulia Igbokwe Philomena
Published: April 2024

Dysregulation or aberrant activation of the phosphatidylinositol 3-kinase (PI3K) signaling pathway is commonly observed in various cancers and is associated with tumor growth, metastasis, and resistance to therapy. Targeting PI3K-α with appropriate inhibitors can disrupt this pathway, hindering cancer progression, and potentially enhancing the immune system’s ability to recognize and eliminate cancer cells. In this study, we aimed to design a novel and potent inhibitor of PI3K-α for cancer immunotherapy using rational drug design techniques, including virtual screening, molecular docking, and 3D-QSAR. We obtained the human PI3K-α protein (6PYS) complexed with (3S)-3-benzyl-3-methyl-5-[5-(2-methylpyrimidin-5-yl)pyrazolo[1,5-a]pyrimidin-3-yl]-1,3-dihydro-2H-indol-2-one (PJ5) from the RCSB Protein Data Bank. Virtual screening of ligands, integrated with predictive computational molecular docking and 3D-field-based-QSAR, was implemented using appropriate Schrödinger Maestro modules. Rational drug design was also carried out, and its clinical relevance was validated across several ADMET descriptors. Docking results suggested that a hybrid of sulfonamide and pyridine-based heterocyclic compounds, functionalized with potent moieties derived from alkaloids, exhibited adequate synergistic biological effects capable of enhancing sufficient biological activity against PI3K-α. A field-based 3D-QSAR model was built on four partial least squares factors, and five statistical metrics were employed to validate the model. The newly designed ligand from this approach, named 6’-amino-5’-(2-fluoro-1,3-oxazol-5-yl)-N-{[3-(hydroxymethyl)oxetan-3-yl]methyl}-3-methyl-[2,3’-bipyridine]-6-sulfonamide or T85, exhibited a predicted bioactivity (pIC50) of 8.25. The predicted ADMET properties of T85 fell reasonably within the range of recommended standards, especially adhering to Lipinski’s rule of five and Jorgensen’s rule of three. In conclusion, the results of this study offer significant insights into in silico drug design using a rational approach, which could expedite the discovery and development of new drug molecules.
Gesundheit von Studierenden des Lehrberufs im Fokus: Diskussion und Perspektiven im deutschsprachigen Raum
Authors: Hascher Tina , Krummenacher Isabelle
Published: April 2024

Der vorliegende Beitrag gibt einen Einblick in den Theorie- und den Forschungsstand zur Gesundheit von Lehramtsstudierenden mit spezifischen Bezügen zu Studierenden in der Schweiz. Dabei werden auch Aspekte der Gesundheit von Lehrerinnen und Lehrern beleuchtet, da Studierende oft schon während ihrer Ausbildung in Schulen arbeiten. Der Beitrag thematisiert Herausforderungen, mit denen Lehramtsstudierende in dieser Doppelrolle konfrontiert sind. Besondere Aufmerksamkeit gilt der Resilienz. Abschliessend werden Ansätze zur Förderung der Resilienz bei Lehramtsstudierenden diskutiert.
Collaboration Among Professionals, Students, Families, and Communities: Effective Teaming for Student Learning
Authors: Denizli Gülboy Hicran
Published: April 2024

The purpose of this study is to examine the book titled "Collaboration Among Professionals, Students, Families, and Communities: Effective Teaming for Student Learning".
Personal Learning Environment and Writing Performance: The Case of Jordanian Young EFL Learners
Authors: Bataineh Mohannad , Bataineh Ruba
Published: April 2024

This study examines the potential effect of incorporating personal learning environment-based instruction on young EFL learners’ writing performance. A quasi-experimental design was used as two intact sixth-grade sections of twenty pupils each from Juffein Primary School for Boys in the Directorate of Education of the Koura District, Irbid (Jordan) constituted the sample of the research. With a toss of a coin, one section was assigned as the control group and the other as the experimental group. A ten-week instructional treatment based on the creation of individual personal learning environments was designed and implemented with the experimental group following proper validation procedures. The control group was instructed using the guidelines of the prescribed Teacher’s Book. A writing test was also designed, validated, and administered to all 40 participants before and after the treatment. The findings revealed that the experimental group outperformed the control group with statistically significant differences found between the two groups in both overall writing and writing features (viz., ideas, organization, sentence fluency, conventions, and legibility). Relevant recommendations and pedagogical recommendations are put forth.