bluuebunny/crossref_metadata_2025 huggingface dataset:
Determination of Effectiveness and Component Classification of Technological Mediums for Finishing Antifriction Non-Abrasive Treatment of Automobile Details
Authors:   Central Ukrainian National Technical University, Krasota Artem , Shepelenko Ihor ,   Central Ukrainian National Technical University, Krasota Mykhailo ,   Central Ukrainian National Technical University, Osin Ruslan ,   Central Ukrainian National Technical University
Published: February 2025

The goal of this research is the determination of selection of technological medium components for finishing antifriction non-abrasive treatment to ensure high-quality of coating.
The research offers a systematization of existing apprehensions of functions and purposes of separate technological mediums components for finishing antifrictional non-abrasive treatment of parts. Was determined the role of technological mediums components and their influence on the finishing antifrictional non-abrasive treatment process. Were analyzed chemical reactions mechanisms occuring during finishing antifrictional non-abrasive treatment of a part.
The analysis of technological medium components and existing approaches of their selection allowed to develop a classification of components according to their functional purpose. According to proposed classification, main components of technological mediums are solvents, surface-active substances, metals and their compounds and dispersive additives, anti-corrosive components, viscosity modifiers. Were examined the properties of each group of technological -medium components, and their influence on antifriction coating formation with increased performance characteristics. Was discussed the mechanism of interaction of different groups during friction-mechanical and frictionchemical detail treatment.
Offered a classification of technological mediums components for FANT according to their functional purpose. Offered approach enables controlled management of the technological mediums with higher quality conditions of surface support.
The research allowed to create a way for choosing technological mediums components during creating technological mediums for finishing antifrictional non-abrasive treatment of automobile parts.
Determined selection of technical medium components for FANT allows obtaining coatings with higher characteristics, ensuring higher reliability and durability of treated details. The optimal application of researched substances, included in technical mediums, allows ensuring development of obtaining antifrictional coatings of FANT development, particularly for improving antifrictional characteristics of automobile, aviation and machinery industries.
Study of the Accuracy Parameters of the Production of Gear Wheels for Hydraulic Gear Pumps Size 1
Authors:   Central Ukrainian National Technical University, Shcherbyna Kyryl , Kyrychenko Andrii ,   Central Ukrainian National Technical University, Aparakin Аnton ,   Central Ukrainian National Technical University, Hodorodozha Viktor ,   Central Ukrainian National Technical University
Published: February 2025

The article presents the results of the study of the accuracy parameters of the manufacturing of gears for hydraulic gear pumps of group 1. The relevance of the work is due to the high requirements for the accuracy of the geometric parameters of the gears, which ensure the efficient operation of the pumps, minimising leakage and power losses.
The study considers the main errors that occur in the manufacture of gears, in particular deviations in profile, pitch, concentricity and side clearances. The influence of these errors on the hydromechanical parameters of the pumps, including efficiency, noise level and wear resistance, is analysed. Modern methods of accuracy control, such as optical and contact profilometry, have been used to provide a quantitative assessment of the accuracy parameters.
On the basis of the results obtained, recommendations for improving the technological processes of gear machining, including the optimisation of shaving and finishing, are proposed. The article also discusses the influence of heat treatment modes on the accuracy and stability of geometric parameters of gears. The analysis of the gear teeth of Group 1 gear pumps by chamfering shows that this method can significantly improve the accuracy of the geometric parameters of the teeth and the quality of their surface. This reduces the roughness of the profile, which has a positive effect on the contact life and performance characteristics of the parts. Shaving also helps to reduce the level of residual stress in the surface layer of the teeth, which increases their resistance to fracture during metal fatigue, especially under variable loads. As a result of the study, the following results were obtained: in fact, the 7th to 8th degree of accuracy according to DIN 3962 is achieved after chamfering. The greatest difference in the indicators is in the accumulated error of the steps and the radial runout of the gear ring.
The results of the study can be used to improve the efficiency and reliability of hydraulic gear pumps, which is important for the fields of mechanical engineering and hydraulic engineering.One of the important issues in the development of mechanical engineering is to improve the efficiency of the functional performance of various mechanisms, including hydraulic gear pumps and motors. Special attention should be paid to the following indicators.
Hashtag Moderasi Beragama
Authors: Taufik Egi Tanadi
Published: February 2025

This study employs social network analysis to examine the use of hashtags associated with oppositional dialectics in the discourse on religious moderation (moderasi beragama) on Twitter/X. Resistance to and rejection of the state-sponsored moderation discourse have emerged in digital spheres, generating a meta-narrative that amplifies marginalized and dissenting voices. Existing studies on moderasi beragama predominantly focus on ontological frameworks, policy implementation, and high-level state narratives. However, limited attention has been given to how the Ministry of Religious Affairs (MoRA) and other state institutions engage in grassroots conversations, where the discourse is actively contested. This article explores how networked citizens engage with the discourse, forming social networks that either support or critique the state's position. Data were collected and analyzed in three phases in October 2022 using the Netlytic program, focusing on five hashtag cases. The dataset comprises 8,626 uploaders and 15,656 tweets. The findings reveal that the state has largely failed to engage in virtual conversations on moderasi beragama. X has arguably become a digital mausoleum of intellectual discourse, yet while the state-defined concept of moderation is familiar to some, its socialization efforts on social media remain significantly weaker than its high-level consortiums and offline initiatives. The study underscores the urgent need for digitally literate ambassadors of moderasi beragama to counteract narratives of resentment and mitigate the proliferation of conspiratorial theories surrounding the discourse.
МОДЕРНІЗАЦІЯ ЕКОНОМІКИ УКРАЇНИ В ПОВОЄННИЙ ПЕРІОД
Authors: Череп Алла , Лещенко Анатолій
Published: February 2025

Стаття досліджує та аналізує виклики та перспективи відновлення економіки України в умовах війни та після її завершення. Увага зосереджена на необхідності модернізації промисловості, адаптації до європейських стандартів через «промисловий безвіз» (АСАА) та гармонізації регуляторних практик. Акцентується на інтеграції України в європейські економічні та технологічні процеси, розвитку «зеленої» енергетики, створенні нових робочих місць, релокації бізнесу та стимулюванні інноваційних галузей. Окремо проаналізовано досвід повоєнної відбудови Німеччини, яка використала план Маршалла для демократичної трансформації, соціальної стабільності та розвитку технологічно-орієнтованої економіки. Підкреслюється ключова роль міжнародної підтримки, інвестиційних механізмів ЄС та розширення експорту до Європи як основи економічної стійкості України. Автори наголошують на важливості стратегічних реформ у сфері врядування, технічного регулювання та впровадження інновацій для забезпечення сталого економічного розвитку та інтеграції в європейські ланцюги доданої вартості.
ЕКОЛОГІЧНА СТАБІЛЬНІСТЬ ЯК КЛЮЧОВА ТЕНДЕНЦІЯ СУЧАСНОГО РОЗВИТКУ ЗАПОРІЗЬКОГО РЕГІОНУ
Authors: Дубиніна Світлана
Published: February 2025

У статті розглянуто основні екологічні проблеми Запорізького регіону, сучасні тенденції вирішення екологічних питань в Україні та в Запорізькому регіоні. Автором розкрито масштабні, катастрофічні наслідки від військових дій на території Запорізького регіону, зміни в екосистемі та навколишньому середовищі, досліджено використання сучасних технологій при моніторингу та оцінці заподіяної шкоди довкіллю регіону. В роботі проаналізовано впровадження сучасних трендів економічної стабільності в світі, в Україні. Особливу увагу приділено перспективним сучасним розробкам та впровадженням цифрової трансформації в Україні, змінам до підходів в науці. У статті надано інформацію щодо векторів діяльності Уряду України в питаннях екологічної стійкості країни та застосування для цього сучасних технологічних розробок. Результатом дослідження в статті визначені ключові напрямки впровадження сучасних тенденцій екологічної стабільності для економічного розвитку в Запорізькому регіоні.
МЕТОДИЧНІ АЛЬТЕРНАТИВИ ДІАГНОСТУВАННЯ ФІНАНСОВОГО СТАНУ ОПЕРАТОРІВ СИСТЕМИ РОЗПОДІЛУ ЕЛЕКТРОЕНЕРГІЇ ТА ЇХ УЗГОДЖЕННЯ
Authors: Куценко Владислав , Ігнашкіна Тетяна
Published: February 2025

Стаття присвячена практичному застосуванню декількох методичних підходів до проведення фінансової діагностики компаній-операторів системи розподілу електроенергії задля отримання більш об’єктивного уявлення щодо їх фінансового стану. В якості методичних альтернатив використано інтегральний метод, дискримінантні моделі Е. Альтмана та О. О. Терещенка, рейтингову оцінку. Об’єктами дослідження виступили вісім вітчизняних компаній. Інтегральна оцінка фінансового стану здійснена з урахуванням авторських позицій щодо системи часткових показників за групами ліквідності, фінансової стійкості, ділової активності, прибутковості, вибору бази порівняння для їх стандартизації, вибору формул згортки останніх в групові та інтегральний індекси. У підсумку виявлено, які компанії за усіма методиками мають стійкий фінансовий стан, а які, навпаки, знаходяться у передкризовому стані.
ІНФОРМАЦІЙНЕ ЗАБЕЗПЕЧЕННЯ ТА ПРОЦЕДУРИ АУДИТУ ФІНАНСОВИХ РЕЗУЛЬТАТІВ ПІДПРИЄМСТВ ІТ СФЕРИ
Authors: Луговець Богдан
Published: February 2025

Стаття присвячена актуальним питанням інформаційного забезпечення та процедурам якісного аудиту фінансових результатів діяльності ІТ підприємства. Проаналізовано особливості фінансової звітності ІТ-підприємств, системи управління відносинами з клієнтами, інструменти для аналізу даних та звітності, етапи аудиту фінансових результатів ІТ підприємств. Доповнено та уточнено класифікацію інформаційного забезпечення проведення аудиту фінансових результатів ІТ компаній та збору аудиторських доказів. Розглянуто найбільш поширені ключові питання аудиту в ІТ сфері, а саме операції з пов’язаними сторонами та закупівля послуг у ІТ спеціалістів. Охарактеризовано основні етапи аудиту фінансових результатів підприємств сфери інформаційних технологій. Досліджено шляхи вирішення ключових питань аудиту фінансових результатів в сфері інформаційних технологій.
ЗНАЧЕННЯ ПІДПРИЄМСТВ ВОДНОГО ТРАНСПОРТУ В НАЦІОНАЛЬНІЙ ЕКОНОМІЦІ УКРАЇНИ
Authors: Хетагурова Наталія
Published: February 2025

Стаття присвячена актуальним питанням формування ефективної системи контролю на основі комплексного аналізу стану водного транспорту України з урахуванням його конкурентоспроможності, ефективності роботи портів, фінансової стабільності підприємств та їхнього внеску в економіку країни. Досліджено місце держави в питаннях розвитку водного транспорту за показниками інфраструктури згідно системи Індексу глобальної конкурентоспроможності. Проаналізовано рівень якості (ефективності надання послуг) морських портів України. Розглянуто динаміку кількості суб’єктів господарювання та кількості зайнятих у водному транспорті. Проведено аналіз динаміки чистого доходу від реалізації продукції (наданих послуг) і чистого фінансового результату діяльності підприємств водного транспорту. Досліджено динаміку та зміни в структурі перевезень окремих видів вантажів морським транспортом.
THE CONTRIBUTION OF INTERNATIONAL BANKS TO SUSTAINABLE TOURISM DEVELOPMENT: BANKING PRACTICES FOR GLOBAL SUSTAINABILITY
Authors: Осипова Світлана , Марина Кривоконь
Published: February 2025

The article examines the contribution of international banks to sustainable tourism development, emphasizing financing projects that reduce environmental impacts and boost economic growth. Financial mechanisms like green bonds, grants, and public-private partnerships, essential for achieving sustainable development goals, are analyzed. Particular attention is paid to the European Investment Bank and the World Bank, focusing on their role in funding infrastructure projects to promote eco-friendly tourism and support local communities through inclusive programs. The study's practical value lies in its relevance for implementing international experience in Ukraine. It provides recommendations for creating an institutional framework to support eco-tourism through international investments. The findings show that involving financial institutions like the World Bank and the European Investment Bank in sustainable tourism development can foster economic growth. These projects generate jobs, aid the recovery of regions with high tourism potential, and balance environmental, social, and economic goals.
ЗЕЛЕНЕ І ЦИФРОВЕ ЛІДЕРСТВО ТА ЇХ ВПЛИВ НА ЕФЕКТИВНІСТЬ РЕАЛІЗАЦІЇ СТРАТЕГІЇ ПІДПРИЄМСТВА
Authors: Бондаренко Світлана , Бондаренко Богдан , Годз Вікторія
Published: February 2025

Стаття присвячена актуальним питанням визначення ролі лідерства у формуванні та реалізації сучасних стратегічних ініціатив на підприємстві. Поняття лідерства характеризується складністю, різноманітністю і мінливістю, тому воно не має уніфікованого підходу до його розкриття. Автори аналізують існуючі визначення лідерства та лідера, наводять характеристику різних типів та моделей лідерства. Особлива увага присвячена виявленню впливу різних типів лідерства на формування та реалізацію стратегії, досягнення сталого розвитку підприємства, його ефективності та стабільності в умовах сучасного бізнес-середовища. Проаналізовано зелені та цифрові моделі лідерства. Сучасне лідерство відіграє ключову роль у формуванні та реалізації стратегії організації, оскільки визначає напрям розвитку, встановлює цілі та бачення підприємства, визначає пріоритети та забезпечує необхідний рівень мотивації для досягнення цілей. Лідер формує стратегічне бачення, яке допомагає визначити майбутній стан підприємства, створюючи чітке уявлення про те, куди воно прямує та яким чином буде досягнуто успіху.
Analysis of macro and micro nutrients in six substrates and leaves for vanilla cultivation (Vanilla planifolia G. Jackson)
Authors: Reyes López Delfino , López Morales Fernando , Bandala Alberto Elfego , Hernández Domínguez Carmela , Pascual Ramírez Fermín , Domínguez Perales Luis Antonio , Vázquez Cruz Fabiel , Hernández Salinas Gregorio
Published: February 2025

Objective: To analyze the physicochemical properties and nutritional content in six substrates and the foliar content of macro and micronutrients in leaves of five phenological stages in vanilla.
Design/methodology/approach: Six substrates were evaluated, in which physicochemical properties and the content of total and available macro and micro nutrients were determined. The foliar content in leaves of five phenological stages in vanilla was also determined. The statistical analysis had a completely randomized design, the substrates and phenological stages were evaluated separately, with two repetitions per treatment.
Results: The substrates analyzed resulted in total amounts of macro and micro nutrients acceptable for good development of vanilla plants and, considering the foliar contents of the leaves, adequate management of the nutrition of the vanilla crop can be achieved.
Limitations on study/implications: The physicochemical analyses of the substrates present total amounts of nutrients for the proper development of vanilla plants. However, their availability must be improved
Findings/conclusions: The foliar contents of macro and micro nutrients in vanilla leaves were different in the stages of plant development, with K being the one with the highest foliar content followed by N, P, Ca and Mg. Considering these foliar contents and the total and available nutritional contents in the substrates can contribute to adequate nutrition planning in vanilla cultivation.
Socio-environmental Study and Ecological Footprint in the Mixtec Community of El Calvario
Authors: Villanueva-Solano José A. , Juárez-López Ana L. , Brito-Carmona Rosa M. , Arellano-Wences Hilda , FORERO FORERO ANGELA VICTORIA , Toribio-Jiménez Jeiry
Published: February 2025

Subject: Currently, it is very difficult for communities to receive funding for their development, as they often lack efficient evaluations or significant impact to support such funding. Therefore, it is vitally important for research to help make these communities visible by applying instruments that describe their situation. In this sense, two of the most important tools are the socio-environmental diagnosis and the ecological footprint, which are rarely determined in various communities.
Methodology: To determine this, Likert-type surveys and interviews with key stakeholders were conducted to identify areas for improvement within the community.
Results: The most relevant findings were the need to pave the road leading to the community, which hinders marketing and increases the cost of its products and/or the residents' labor. Another issue is the management, disposal, and elimination of waste. The greatest waste identified is the bagasse from agave, which must be valorized. Additionally, efficient water collection systems are needed, and finally, there is a lack of medicines and an available family doctor.
 Implications: As a result of this study, various strategies are proposed to provide continuity to the areas of opportunity identified in the El Calvario community.
Conclusions: It is important to listen to the community's context so that they become the promoters of change, without harming the environment and nature.
Xây dựng qui trình định lượng đồng thời allopurinol và chất chuyển hóa oxypurinol trong huyết tương người bằng kỹ thuật HPLC-DAD
Authors: Lê Thị Thu Cúc , Ngô Thị Minh Tâm , Lê Minh Tài , Nguyễn Quang , Lương Bắc An , Lê Hoàng Gia Linh , Đỗ Đức Minh , Nguyễn Đức Tuấn
Published: February 2025

Đặt vấn đề: Allopurinol (ALO) là thuốc thuộc nhóm ức chế tổng hợp acid uric, sau khi hấp thu vào cơ thể được chuyển hóa phần lớn thành chất chuyển hóa có hoạt tính là oxypurinol (OXY).

Mục tiêu nghiên cứu: Xây dựng quy trình định lượng đồng thời ALO và chất chuyển hóa OXY trong huyết tương người bằng HPLC-DAD.

Đối tượng và phương pháp nghiên cứu: Đối tượng nghiên cứu là các mẫu huyết tương người giả lập chứa ALO và OXY. Mẫu huyết tương được xử lý bằng phương pháp tủa protein và tiến hành định lượng đồng thời ALO và OXY bằng HPLC-DAD

Kết quả: Mẫu huyết tương người chứa ALO và OXY và chuẩn nội acyclovir đã được tủa protein bằng acid percloric 10%, hiệu suất chiết ổn định trên 90% với CV < 15%. Điều kiện sắc ký: cột Gemini NX C18 (150 × 4,6 mm; 5,0 µm); thể tích tiêm mẫu 40 µL; pha động là dung dịch acid formic 0,1%; tốc độ dòng 0,7 mL/phút; bước sóng phát hiện 254 nm. Khoảng tuyến tính: 0,10 - 20 μg/mL (ALO) và 0,09 – 18 μg/mL (OXY). Giới hạn định lượng dưới (LLOQ) là 0,10 μg/mL (ALO) và 0,09 μg/mL (OXY). Quy trình thẩm định đã được áp dụng để phân tích một số mẫu huyết tương người bệnh gút đang được điều trị bằng ALO.

Kết luận: Quy trình định lượng đồng thời ALO và chất chuyển hóa OXY trong huyết tương người bằng kỹ thuật HPLC-PDA có độ nhạy, độ đặc hiệu, độ chính xác, độ đúng cao. Quy trình có thể được ứng dụng để định lượng ALO và OXY trong huyết tương người trong các nghiên cứu dược động học và tương đương sinh học.

Từ khóa: Allopurinol; oxypurinol; huyết tương người; HPLC-DAD
Tổng hợp biaryl bất đối xứng trục chứa dị vòng tiềm năng sinh học
Authors: Huỳnh Hoàng Thúc , Đặng Thiên Phước , Nguyễn Quí Hiển
Published: February 2025

Mục tiêu: Trở chuyển phân (atropisomer) là một xu hướng đang lên trong khám phá thuốc mới. Các nghiên cứu gần đây đã phát triển thành công phản ứng tạo nối biaryl chọn lọc lập thể trở chuyển phân, ứng dụng cho một số dị vòng thơm cụ thể. Nhằm góp phần mở rộng phạm vi cơ chất dị vòng cho phản ứng này, chúng tôi nghiên cứu khảo sát thêm một số điều kiện aryl hóa, tạo sản phẩm trở chuyển phân dưới dạng hỗn hợp tiêu triền (racemic), và ứng dụng tổng hợp các sản phẩm biaryl trở chuyển phân khác mang các dị vòng có tiềm năng hoạt tính sinh học.

Đối tượng và phương pháp nghiên cứu: Chúng tôi khảo sát các điều kiện phản ứng từ quy trình của Fagnou, như nguồn và tỉ lệ Pd, dung môi, nhiệt độ, thời gian đun. Điều kiện phản ứng này sau đó được áp dụng cho tổng hợp các hợp chất biaryl dị vòng trở chuyển phân.

Kết quả: Bằng cách thay đổi dung môi, nhiệt độ, nguồn Pd, phản ứng cho hiệu suất tốt hơn quy trình của Fagnou đối với cơ chất cồng kềnh. Năm sản phẩm biaryl trở chuyển phân mới đã được tổng hợp, cấu trúc của chúng được chứng minh bằng các dữ liệu phổ.

Kết luận: Quy trình mới được ứng dụng để tổng hợp các hợp chất trở chuyển phân mới, là tiền đề cho các nghiên cứu ứng dụng trở chuyển phân trong khám phá thuốc mới, cũng như làm tiền chất tổng hợp một số hợp chất thiên nhiên.

Từ khóa: Trở chuyển phân; dị vòng thơm; biaryl; hoạt hóa liên kết C-H
Neuro-Behçet Syndrome Triggered by Illicit Drug Use: Case Presentation and Literature Review
Authors:   Maltepe University Hospital-Department of Internal Medicine, MERT PINAR , Öner KAYA Fatih , YÜKSEL Atakan , NALBANT Selim ,   Maltepe University Hospital-Department of Internal Medicine, Florentina ATEŞ Miruna ,   Maltepe University Hospital-Department of Neurology
Published: February 2025

Behcet's disease is a chronic systemic inflammatory disorder that is characterized by recurrent oral and genital aphthous ulcers,
skin lesions, uveitis, as well as the involvement of different organs, including the central nervous system (CNS) [1]. Neurological
manifestations, better known as neuro-Behcet's (NB), occur in about 5-10% of cases, ranging from headaches and impaired
cognition to severe neurological deficits [2,3]. This case report describes a unique case of neuro-Behcet's disease in a patient with
substance use in the background, and it adds to knowledge while enhancing further understanding of this complex interplay and
its implications regarding management
OPTIMALISASI PENGELOLAAN KEUANGAN DESA UNTUK PEMBANGUNAN BERKELANJUTAN : STUDI KASUS DESA PASIRTALAGA
Authors: Gun Gumilar Gun , Sugiarto Dimas , Elyas Ahmad Mudzaki , Atika Ayu
Published: February 2025

The Village Fund in Indonesia launched in 2015 through the policy of Village Law No. 6/2014 provides a strong impetus for villages to independently manage their financial resources to achieve inclusive, prosperous, and environmentally friendly development. This study aims to analyse how village financial management can be optimised to support sustainable development.  The theory used is sustainable development which consists of three main pillars, namely economic, social, and environmental, developed by the Brundtland Commission (1987). This research uses a qualitative approach with a case study method that aims to explore efforts to optimise village financial management in supporting sustainable development in Pasirtalaga Village. The case study was chosen because it provides an in-depth description of the local dynamics of village financial management that is unique and specific to the context of Pasirtalaga Village.  The results showed that optimised village financial management can improve the efficiency of allocating funds to development projects that can improve the economy, increase social welfare and maintain sustainability.
EFEKTIVITAS PEMERINTAHAN TRANSFORMASIONAL DALAM MENINGKATKAN KETERLIBATAN MASYARAKAT DESA: STUDI DI MAIWA KABUPATEN ENREKANG
Authors: Haeruddin Haeruddin , Nonci Nurjannah , Erfina Erfina , Sam Muliani
Published: February 2025

This research aims to analyze the factors that influence community participation in village governance and the role of the village government in increasing such participation. This study also examines the relationship between village government leadership, transparency, public services, and coordination with community leaders on the level of community participation in village development. The method used in this research is a qualitative approach with a descriptive research type. Data were collected through in-depth interviews, observation, and documentation studies. The data were analyzed using thematic analysis. The collected data were analyzed using thematic analysis to identify patterns that exist among the variables studied. The results showed that transformational leadership, transparency, and active community participation play a significant role in improving the quality of village governance. Communities tend to participate more actively in village meetings and decision-making when there is clarity of information and good public services. In addition, the role of community leaders and the use of information technology also have a positive impact on the community participation process. The implication of this study is the importance of increasing the capacity of village governments in improving transparency mechanisms and public services, as well as strengthening coordination with community leaders to expand community participation.
PERAN KEPALA DESA DALAM PENYELESAIAN KONFLIK AGRARIA LOKAL (STUDI KASUS DI DESA SERA TENGAH KECAMATAN BLUTO)
Authors: Vicry Jaysal , Maisaroh Siti , Mafluhah Mafluhah , Rohman Habibur
Published: February 2025

As stated in Law Number 6 of 2014 on Village, the Village Head is required to maintain peace and order in the village community, so that if a conflict occurs in the community, it is the responsibility of the Village Head to resolve it. This study aims to analyze the role of the Chief of Village in resolving agraria conflicts, in this case land disputes in Sera Tengah Village, Bluto District. The research method uses a qualitative approach with data collection techniques using interviews and participatory observation. The results of this study are that the role of the Chief of Village is very significant in resolving agraria conflicts in Sera Tengah Village. The role of the Chief of Village, which is his responsibility, can resolve agraria conflicts without continuing to the court process. The resolution mechanism is in the form of Complaints to the Chief of Village or village apparatus, problem analysis, data/evidence analysis, mediation and ends with the decision process issued by the chief of village with the disputing parties witnessed directly by the Sera Tengah Village Apparatus.
PERAN PEMERINTAH PEKON DALAM MENINGKATKAN KUALITAS PELAYANAN PUBLIK
Authors: Aulia Sari Putri , Inti Suryani Eny , Yonnawati Yonnawati
Published: February 2025

The role of village government is very important for the progress of a village. One of the functions of village government is to provide services while improving the quality of public services to the community in order to create a developed and prosperous society. As the government unit closest to the community, the pekon government functions as a liaison between the needs of the community and the policies taken by the government at a higher level. The aim of this research is to find out the role of the Pekon Government in improving the quality of public services in Pekon Teba Pering Jaya, Sukau District, West Lampung Regency in 2023. The research method used is qualitative with a descriptive approach with data collection using observation, interviews and documentation. Data analysis consists of reduction stages, data presentation, and drawing conclusions. The results of this research show that the Pekon government's role in efforts to improve the quality of services in Pekon Teba Pering Jaya is not yet optimal. This is due to the lack of facilities used in administrative services, so there is a need for proposals to procure facilities through village funds. There are Pekon officials who are not yet skilled in using electronic media or digital platforms, so socialization and training should be held to develop the human resources (HR) of Pekon Teba Pering Jaya officials.
Lupus Vasculitis, A Rare Diagnosis and a Therapeutic Challenge: A Case Report
Authors: Ramos Ana Rita , Duarte Rui , Rolado Marisa , Alves Rita Valerio , Santos Paulo
Published: February 2025

Background: More than 50% of patients have renal involvement in systemic lupus erythematosus (SLE) and may present different patterns according to glomerular, tubulointerstitial, and vascular involvement. Lupus vasculitis (LV), the least frequent renal vascular lesion encountered in SLE, is a serious clinicopathological entity rarely described, and its therapeutic guidelines are not formally defined.

Case presentation: The authors present a case of a 44-year-old woman with SLE admitted to the hospital with a history of general tiredness, worsening of polyarthralgia, hypertension, oedema, and chest pain with new kidney failure, hematuria, and proteinuria. A kidney biopsy was performed, establishing the diagnosis of Class IV lupus nephritis associated with LV, and intravenous cyclophosphamide was started according to the CYCLOPS protocol. She developed orthopnoea associated to peripheral oedema, leading to a diagnosis of lupus myocarditis, and the treatment was adjusted to mycophenolate mofetil with rituximab, resulting in the resolution of symptoms.

Conclusion: LV is a rare condition, and there are no consensus or protocol guidelines
for the treatment of this pathology, whose severity requires an emerging diagnostic
and therapeutic approach.
DAR ALAN OYUNLARINDA FARKLI GÖREV VE SAYIDA JOKER OYUNCU KULLANIMININ FİZİKSEL VE FİZYOLOJİK PARAMETRELERE ETKİSİ
Authors: Şentürk Deniz , Kumak Aliasker , Akyıldız Zeki , Kirişci İlker
Published: February 2025

Bu araştırmanın amacı 1 jokerli ve 2 jokerli küçük alan oyunlarının jokersiz oyunlara göre ivmelenme, yavaşlama, farklı hız aralıklarında yapılan koşu mesafeleri, maksimal kalp atım hızının %80-90-100’ünde geçirilen toplam süre üzerine etkisini incelemekti. Araştırma 4 hafta süre ile haftada 1 gün olacak şekilde tasarlandı. Familirizasyon oturumu sonrasında, 24x36 m saha ölçülerinde 4 dakika süre ile rastgele bir seçimle 1’er set 4’e 4, 4’e 4+1 ve 4’e 4+2 formatlarını içeren küçük alan oyunları oynatıldı. Anlamlılık alfa düzeyi olarak 0,05 olarak belirlendi. Yüksek yoğunluklu parametrelerde jokersiz oyuna göre 1 jokerli ve 2 jokerli oyunlarda anlamlı bir değişim gözlemlenmedi. Ancak, yavaşlama (-1.99-1.00 m/sn²), ivmelenme (-1.99-1.00 m/sn²), KAH dk. [atım.dk-1] ve KAH ort. [atım.dk-2] parametrelerinde 1 jokerli oyunda jokersiz oyuna kıyasla anlamlı sonuçlar gözlemlendi. İvmelenme (-1.99-1.00 m/sn²) parametresi dışında 2 jokerli oyunlarda 1 jokerli ve jokersiz oyunlara göre tüm parametrelerde istatistiksel olarak anlamlı düzeyde yüksek fiziksel ve fizyolojik bir parametrede artış meydana gelmediğini göstermektedir. Bu sonuçlar: (i) jokersiz oyunlara kıyasla 1 jokerli oyunlarda orta yoğunluktaki yavaşlama, ivmelenme ve ortalama kalp atım hızı verilerinde anlamlı ölçüde artışa neden olduğunu, (ii) jokersiz ve 1 jokerli oyunlara kıyasla 2 jokerli oyunlarının hiçbir parametrede anlamlı artışa neden olmadığı görülmektedir
3D bioprinting for the construction of drug testing models-development strategies and regulatory concerns
Authors: Mallya Divya , Gadre Mrunmayi Ashish , Varadharajan S. , Vasanthan Kirthanashri S.
Published: February 2025

A drug to be successfully launched in the market requires a significant amount of capital, resources and time, where the unsuccessful results in the last stages lead to catastrophic failure for discovering drugs. This is the very reason which calls for the invention of innovative models that can closely mimic the human in vivo model for producing reliable results. Throughout the innovation line, there has been improvement in the rationale in silico designing but yet there is requirement for in vitro-in vivo correlations. During the evolving of the drug testing models, the 3D models produced by different methods have been proven to produce better results than the traditional 2D models. However, the in vitro fabrications of live tissues are still bottleneck in realizing their complete potential. There is an urgent need for the development of single, standard and simplified in vitro 3D tissue models that can be reliable for investigating the biological and pathological aspects of drug discovery, which is yet to be achieved. The existing pre-clinical models have considerable drawbacks despite being the gold standard in pre-clinical research. The major drawback being the interspecies differences and low reliability on the generated results. This gap could be overcome by the fabrication of bioengineered human disease models for drug screening. The advancement in the fabrication of 3D models will provide a valuable tool in screening drugs at different stages as they are one step closer to bio-mimic human tissues. In this review, we have discussed on the evolution of preclinical studies, and different models, including mini tissues, spheroids, organoids, bioengineered three dimensional models and organs on chips. Furthermore, we provide details of different disease models fabricated across various organs and their applications. In addition to this, the review also focuses on the limitations and the current prospects of the role of three dimensionally bioprinted models in drug screening and development.
Characteristics of gut microbiota and metabolites in extrahepatic cholangiocarcinoma and their prognostic value for resectable lesions
Authors: Ye Cheng , Zhang Bo , Lin Yanyan , Han Fangfang , Shi Huaqing , Dong Chunlu , Zhou Wence
Published: February 2025

This study aimed to investigate the relationship between gut microbiota composition, fecal metabolites, and postoperative prognosis in patients with extrahepatic cholangiocarcinoma (eCCA). A total of 53 patients with resectable eCCA and 21 healthy volunteers as a control group were included. 16S rRNA gene sequencing and metabolomic analyses revealed significant differences in the gut microbial community structure and altered fecal metabolites profiles between eCCA patients and healthy controls. Univariate and multivariate Cox regression analyses indicated that factors such as preoperative total bilirubin, indirect bilirubin, and specific metabolites were closely associated with overall survival in patients with eCCA post-surgery. The constructed nomogram model further demonstrated the predictive value of these factors, achieving a C-index of 0.718, with calibration curves confirming its strong predictive performance. In conclusion, gut microbiota composition and fecal metabolites play a crucial role in the surgical prognosis of eCCA patients, providing new insights for clinical prognostic assessment.
A chionodracine-derived peptide, KHS-Cnd, as an anti-virulence agent against multidrug-resistant Acinetobacter baumannii clinical strains
Authors: Artini Marco , Paris Irene , Imperlini Esther , Buonocore Francesco , Vrenna Gianluca , Papa Rosanna , Selan Laura
Published: February 2025

About 71% of healthcare-associated infections are due to antibiotic-resistant bacteria, such as carbapenem-resistant A. baumannii, classified by World Health Organization into a critical priority group of pathogens. The antimicrobial resistance profile of A. baumannii relies on its ability to produce several virulence factors, including biofilm formation. Its ability to adhere and persist on surfaces as biofilm has contributed to its pathogenicity and drug resistance. In this study, the ability of an antimicrobial peptide (a chionodracine-derived peptide named KHS-Cnd) to inhibit or reduce biofilm formation was investigated as an example of a potential strategy to counteract infections caused by biofilm-forming pathogens. To this aim, the antimicrobial profiles were first analyzed in selected A. baumannii strains, two reference and six clinical strains, all biofilm-forming with different capability, regardless of whether they are drug resistant or sensitive. Successively, we investigated the bactericidal activity of the peptide that showed MIC values ranging from 5 to 10 µM and a significative antibiofilm activity on all tested strains at sub-inhibitory concentrations. In fact, KHS-Cnd can hinder biofilm A. baumannii strains formation with an inhibition percentage ranging between 65% and 10%. Also a statistically significant reduction of mature biofilm ranging from 20% to 50% was observed in four out of eight tested A. baumannii strains. KHS-Cnd impacts various stages of biofilm formation, including the inhibition of surface-associated and twitching motilities depending on the different strain. In particular, our results showed that only two strains possessed surface-associated motility that was strongly impaired by KHS-Cnd treatment; three clinical strains, instead, showed twitching motility, whose inhibition for two of them was evident after 24 h of incubation with peptide. Moreover, the invasion of pulmonary cells by A. baumannii was significantly impaired with a reduction of about 32% after treatment with 1.25 µM KHS-Cnd. Finally, when the peptide was used together with ceftazidime/avibactam against resistant A. baumannii strains, it was able to reduce the minimal inhibitory concentration of antibiotics needed to inhibit the microorganism growth.
Analysis and validation of biomarkers and immune cell infiltration profiles in unstable coronary atherosclerotic plaques using bioinformatics and machine learning
Authors: Jin Pengyue , Zhang Shangyu , Yang Li , Zeng Yujie , Li Yongguo , Tang Renkuan
Published: February 2025

Introduction

Decreased stability of coronary atherosclerotic plaques correlates with a heightened risk of acute coronary syndrome (ACS). Thus, early diagnosis and treatment of unstable plaques are imperative in averting adverse cardiovascular events. This study aims to identify diagnostic biomarkers for unstable coronary atherosclerotic plaques and investigate the role of immune cell infiltration in their formation.

Methods

The datasets GSE163154 and GSE111782, obtained from the gene expression omnibus (GEO) database, were amalgamated for bioinformatics analysis, using the dataset GSE43292 as a test set. Sequentially, we performed principal component analysis (PCA), differential gene expression analysis, enrichment analysis, weighted gene co-expression network analysis (WGCNA), utilized a machine learning algorithm to screen key genes, conducted receiver operating characteristic (ROC) curve analysis and nomogram model to assess biomarker diagnostic efficacy, validated the biomarkers, and analyzed immune cell infiltration.

Results

In conclusion, enrichment analyses demonstrate that genes are significantly enriched in inflammatory and immune-related pathways. We identified HSPA2 and GEM as key genes and validated them experimentally. Significant differences existed in immune cell infiltration between subgroups. Additionally, HSPA2 and GEM showed significant associations with a wide range of immune cells.

Discussion

HSPA2 and GEM can function as diagnostic biomarkers for unstable coronary atherosclerotic plaques. In combination with immune cell infiltration analyses, our study provides new insights into the future study of unstable plaque occurrence and molecular mechanisms.
Deep learning for accurate classification of conifer pollen grains: enhancing species identification in palynology
Authors: Rostami Masoud A. , Kydd LeMaur , Balmaki Behnaz , Dyer Lee A. , Allen Julie M.
Published: February 2025

Accurate identification of pollen grains from Abies (fir), Picea (spruce), and Pinus (pine) is an important method for reconstructing historical environments, past landscapes and understanding human-environment interactions. However, distinguishing between pollen grains of conifer genera poses challenges in palynology due to their morphological similarities. To address this identification challenge, this study leverages advanced deep learning techniques, specifically transfer learning models, which are effective in identifying similarities among detailed features. We evaluated nine different transfer learning architectures: DenseNet201, EfficientNetV2S, InceptionV3, MobileNetV2, ResNet101, ResNet50, VGG16, VGG19, and Xception. Each model was trained and validated on a dataset of images of pollen grains collected from museum specimens, mounted and imaged for training purposes. The models were assessed on various performance metrics, including accuracy, precision, recall, and F1-score across training, validation, and testing phases. Our results indicate that ResNet101 relatively outperformed other models, achieving a test accuracy of 99%, with equally high precision, recall, and F1-score. This study underscores the efficacy of transfer learning to produce models that can aid in identifications of difficult species. These models may aid conifer species classification and enhance pollen grain analysis, critical for ecological research and monitoring environmental changes.
Low-loss power management strategy for weak and low-frequency biomechanical energy harvesting for new generation wearable electronics
Authors: Li Weilu , Huang Yongcan , Liu Chunhua , Valencia Agnes , Daoud Walid A.
Published: February 2025

Introduction

Amidst the rapidly growing development of wearable electronics, their dependence on external power sources increases the power expense while leading to interruptions of their operation during charging. Biomechanical energy harvesters offer a promising solution for self-powered wearable electronics by converting waste kinetic energy to electricity. Despite successful efforts in advancing their power outputs from μW to mW, several challenges persist, including low output current at the μA-level, high internal impedance in the GΩ-level, and AC outputs, restricting their practical applications. Conventional power management circuits are commonly utilized in high-frequency harvesters without adequate consideration of the energy loss that incurs, potentially leading to circuit failure when used in low-frequency harvesters with a lower power output.

Methods

Here, we introduce a low-loss power management circuit (L-PMC) that functions under low-frequency conditions to facilitate biomechanical energy harvesting.

Results

Our innovative two-stage energy transfer strategy boosts the energy extraction efficiency to 42.24%, breaking previous records. With an energy transfer efficiency of 30.59%, L-PMC can charge a battery from 1.9 V to 2.4 V in just 10 min.

Discussion

Moreover, the integration of passive current amplification tripled charge accumulation and energy storage, representing 207% enhancement in energy transfer efficiency, presenting a versatile and universal approach to low-frequency biomechanical energy harvesting for new generation wearable electronics.
Geochemical factors influencing the phosphorus mobility in Konza prairie grassland and agriculture-dominated soils in north-eastern Kansas
Authors: Banerjee Protik , Kulkarni Harshad V. , Veach Allison M. , Nagaraja Thiba , Pathak Pousali , Das Suprem R. , Datta Saugata
Published: February 2025

Introduction

The availability and mobility of phosphorus (P) in soils play a crucial role in effectively managing agricultural activities and maintaining healthy soils. Several parameters including soil texture, pH, elemental and mineralogical composition, moisture content, and soil organic matter (SOM) are crucial in controlling the movement of P in soils. This study focuses on assessing geochemical properties of soils from a pristine prairie grassland and an agriculturally dominated land, and their influence on soil P mobility.

Methods

Surface soils were collected from two locations, Konza Prairie Biological Station (KBPS) located in Manhattan (Kansas) which is a native grassland ecosystem, and agricultural land in town of Hays (Kansas).

Results

Results showed that the KPBS soils contained lower water-extractable phosphate (PO43—) concentrations (0.2 ± 0.7 mg/kg) than soils from Hays (1.3 ± 2.4 mg/kg). Bio-available P measured as Bray-P were also lower in KPBS (14.3 ± 7.0 mg/kg) relative to Hays (23.0 ± 23.7 mg/kg). Soils from both the sites contained water-extractable calcium, magnesium and potassium as a primary soluble component likely from carbonate minerals in these calcareous soils. The SOM concentrations measured as loss on ignition (LoI) were greater in KPBS (9.9% ± 1.8%) relative to Hays (5.3% ± 1.7%). Water extractable soil organic carbon (WE-SOC) concentrations were also greater for KPBS (651 ± 274 mg/kg) relative to Hays (288 ± 267 mg/kg). Optical spectroscopic analyses using absorbance and fluorescence properties revealed that the water-extractable SOM in these soils was mainly of terrestrial origin, plant-derived, aromatic, and contained humic-like substances. The intensities of fluorescence peaks A, C, and M, and specific UV absorbance at 254 nm (SUVA 254) of both soils correlate strongly with the Bray-P concentrations, indicating that the source of SOM plays a vital role in controlling soil P mobility.

Conclusion

These findings indicate that natural prairie grassland soils contained lower P concentrations that are primarily insoluble in water and associated with humic and fulvic-like SOM.
Big lessons from the little Akkermansia muciniphila in hepatocellular carcinoma
Authors: Yang Yanguang , Shi Xinli
Published: February 2025

Hepatocellular carcinoma (HCC) is the most frequently occurring type of liver tumor and is considered one of the most common primary malignant neoplasms. The prognosis for HCC is dismal because of its complicated etiology and high level of medication resistance. Immunotherapy is presently regarded as one of the most effective therapeutic options for HCC; nevertheless, because of the disturbance of intestinal flora, immunotherapy shows low antitumor efficacy. An increasing body of research indicates that intestinal flora, particularly Akkermansia muciniphila (A. muciniphila), is vital for the treatment of tumors. Studies have demonstrated that the diminished effectiveness of immunotherapy in cancer patients is associated with a reduction in A. muciniphila levels, suggesting that increasing A. muciniphila levels significantly enhance the efficacy of immunotherapy. A. muciniphila functions as a gut probiotic and can treat and prevent a wide range of illnesses, including cancer. Consequently, preserving A. muciniphila abundance is enough to prevent and lower the danger of developing cancer disorders. In this review, we critically evaluate the current body of research on A. muciniphila, with a primary focus on its biological properties and functions. The different illnesses that A. muciniphila treats were then discussed, particularly the way it works with liver cancer. This review aims to give a novel treatment plan for patients with HCC as well as a theoretical foundation for improving HCC immunotherapy.
Macrophage pyroptosis and its crucial role in ALI/ARDS
Authors: Cai Yuju , Shang Luorui , Zhou Fangyuan , Zhang Mengqi , Li Jinxiao , Wang Shuhan , Lin Qifeng , Huang Jianghua , Yang Shenglan
Published: February 2025

Acute lung injury(ALI)/acute respiratory distress syndrome(ARDS) is a severe clinical syndrome characterized by high morbidity and mortality, primarily due to lung injury. However, the pathogenesis of ALI/ARDS remains a complex issue. In recent years, the role of macrophage pyroptosis in lung injury has garnered extensive attention worldwide. This paper reviews the mechanism of macrophage pyroptosis, discusses its role in ALI/ARDS, and introduces several drugs and intervening measures that can regulate macrophage pyroptosis to influence the progression of ALI/ARDS. By doing so, we aim to enhance the understanding of the mechanism of macrophage pyroptosis in ALI/ARDS and provide novel insights for its treatment.