bluuebunny/crossref_metadata_2025 huggingface dataset:
Formação continuada no Amapá: as percepções dos educadores sobre o Encontro Pedagógico dos Municípios
Authors: Bezerra Eliodete Coelho , Gentilini João Augusto
Published: February 2020

Este artigo apresenta as percepções dos professores participantes e dos técnicos que elaboraram e ministraram cursos dentro do Projeto de formação Continuada de professores no estado do amapá, intitulado Encontro Pedagógico dos Municípios, e baseia-se nos resultados de pesquisa do mestrado em Educação que teve como objetivo central analisar e descrever o referido Projeto, bem como estudar o impacto que este causou no contexto educacional dos municípios. foi realizado um estudo da trajetória desse Projeto, compreendendo sua concepção teórica, implementação e, principalmente, alguns dos resultados obtidos. a metodologia da pesquisa consistiu na coleta e análise de documentos e na realização de 14 entrevistas com os sujeitos da pesquisa. Os depoimentos obtidos deixam claro que o Encontro Pedagógico teve um grande impacto na realidade educacional dos municípios, apresentando mais resultados positivos do que negativos tanto para os professores quanto para os ministrantes e os coordenadores das ações. Os depoimentos permitem concluir também que ações de formação continuada não atingirão o objetivo almejado se não vierem acompanhadas de políticas públicas direcionadas à melhoria das condições de vida e trabalho dos professores.
O Uso de Dispositivos Móveis no Contexto Educativo: Análise de Teses e Dissertações Nacionais
Authors: Almeida Rosiney Rocha , De Araújo Jr Carlos Araújo Fernando
Published: February 2020

Esta pesquisa se propõe analisar o estado da arte do uso de dispositivos móveis no ensino formal no Brasil. Utilizou-se como metodologia a análise do conteúdo, Bardin (2009). Foram analisadas teses e dissertações depositadas no Banco de teses e dissertações da CAPES, no período de 2003 a 2012. Os resultados apontam para a necessidade de se investigar com acuidade esse campo de pesquisa e discussões por meio de Programas de Pós--graduação ligados à educação do país. A análise do foco das pesquisas sobre o uso de dispositivos móveis no ensino permitiu identificar que grande parte é voltada para o Ensino superior, necessitando, portanto, de iniciativas que contemplem também os demais níveis de ensino. Também, os resultados assinalam a necessidade de se encorajar o processo de aprendizagem fora da sala de aula tradicional, visto que o uso desses recursos ainda está restrito ao espaço físico de uma sala de aula. O foco das pesquisas em m-learningtem sido, na sua maioria, os alunos, com destaque para o processo de aprendizagem. Assim, verifica-se a necessidade de mais pesquisas que analisem o papel do professor, como mediador nesse processo
A Crítica Feminista à Ciência e Contribuição à Pesquisa nas Ciências Humanas
Authors: Cruz Maria Helena Santana
Published: February 2020

O propósito que norteia este artigo centra-se em torno das contribuições trazidas pela epistemologia feministas à ciência e à pesquisa nas ciências humanas e sociais, particularmente na área da educação. A reflexão parte da formulação de uma crítica em relação a alguns pressupostos, os quais nortearam a produção do conhecimento científico, tais como a condição de neutralidade, universalismo e objetividade da ciência, além de seu caráter androcêntrico. Enfatiza a relevância dos estudos de gênero na medida em que as críticas produzidas fazem surgir novos modelos e conceitos para conceber, realizar pesquisas e analisar diferentes aspectos da sociedade, sempre com um viés progressista, a fim de contribuir com transformações sociais.
Um debate sobre a escola como tecnologia político-cultural
Authors: Thürler Djalma , Dos Santos Josué Leite
Published: February 2020

Os pressupostos teóricos deste estudo baseiam-se primordialmente na interseção dos Estudos Culturais e seus desdobramentos nos estudos pós-modernos, pós-estruturalistas e teoria queer voltados para a educação, sexualidades, gênero e masculinidades sob a ótica das reflexões das relações escola, conhecimento/ saber e poder, currículo e cultura. Ao articularmos conjuntamente as contribuições dessas matrizes epistemológicas, nos foi possível estabelecer uma reflexão acerca da escola nos processos de materialidade dos corpos enquanto artefato performativo (BUTLER, 2010).
Relações de Classe e Gênero na Escola: revisitando conceitos de igualdade, desigualdade, diferença, classe e gênero
Authors: Ferreira Maria Mary
Published: February 2020

A proposta deste artigo é discutir os conceitos de igualdade, diferença, identidade, classe e gênero na perspectiva de refletir e entender como estes conceitos marcam a construção da identidade tendo a escola como lócus. Compreende-se que as desigualdades sociais se estabelecem a partir das relações de classe, raça e gênero que se entrecruzam com as diferenças culturais que por sua vez estão relacionadas ao reconhecimento e valorização do outro. Somos diferentes em função de vários fatores: raça/etnia, sexo, gostos, lugares onde habitamos, orientação sexual, entre outros pontos que nos diferenciam uns dos outros. Essas diferenças, porém, não devem ser tratadas de forma desigual, deve contribuir para marcar nossa identidade e fortalecer nossos laços e relações com o outro. Assim, ao refletir esses conceitos espera-se contribuir para ampliar o debate nas escolas e universidades espaços considerados fundamentais para alterar as relações de poder e de gênero com vistas à construção de uma sociedade de iguais.
Gênero e sexualidade no lócus família/ escola: incursões deflagradas a não heterossexualidade e os desafios para a cidadania reconhecida
Authors: Di Gregorio Maria de Fátima , Silva Karine Nascimento
Published: February 2020

Vislumbram-se neste estudo, possibilidades de diálogo entre o tema Educação, Gênero, Diversidade Sexual e Direitos Humanos no lócus da Família e da Escola, tendo o recorte na sexualidade não heterossexual e seus desafios desde a orientação na família e a construção das identidades de gênero no cenário escolar/social. Sabe-se que nesses espaços, a violência homofóbica se materializa, legitimando condutas preconceituosas nos diversos âmbitos da sociedade. Com base em estudos bibliográficos e a partir de pesquisas realizadas em campo empírico–escolas públicas do município de Jequié/BA – discute-se o tema, salientando-se a importância do refletir sobre as posturas estigmatizadoras das pessoas na família e na própria escola e a garantia dos Direitos Humanos através da criação de ações e políticas públicas promotoras de uma cultura de paz e do respeito à diversidade humana. A pesquisa mostrou que se faz necessário criar condições propícias para a emergência de novos paradigmas na família e na escola, com olhar voltado para a questão da legitimação dessas condutas preconceituosas, onde pensar a alteridade fundamenta o resgate de uma ética mais comprometida com o processo de inclusão social.
Gênero, sexualidade e educação: perspectivas em debate
Authors: De Santana Anabela Maurício
Published: February 2020

O presente artigo analisa a reprodução das relações de gênero no âmbito da relação homoafetiva, possibilitando uma reflexão acerca do que é ser homem e do que é ser mulher e seus respectivos papéis na sociedade e na família e problematiza as relações existentes entre gênero e sexualidade na educação. A pesquisa tem por objetivo problematizar as relações existentes entre gênero e sexualidade na educação, a partir da perspectiva dos Estudos Culturais e dos Estudos Feministas, tendo como marco teórico a abordagem pós-estruturalista de análise e adota-se como ideias norteadoras a mulher lésbica na relação homoafetiva, o que ela anseia e as maneiras que tem encontrado para driblar o preconceito, a rejeição, a agressividade e o decesso às políticas públicas para essas mulheres. A pesquisa teve como sujeitos quatro mulheres que se intitulam lésbicas e com o intento de fazer esta investigação foram utilizados os meses de setembro, outubro e novembro de dois mil e dez, tendo como locus o município de Itaporanga d’Ajuda/Se.
Instrução e política na província de Sergype durante o processo de construção do estado nacional (1820-1850)
Authors: Ferronato Cristiano , Dos Santos Joelson Silva , Da Silva Joseane Gonçalves , Amorim Simone Silveira
Published: February 2020

Este trabalho é resultante da pesquisa “A instrução secundária pública e particular nos relatórios, mensagens e falas de presidentes da Província de Sergipe. (1840-1870)”. Tem como objetivo apresentar algumas considerações iniciais sobre a questão da instrução pública na Província de Sergype, durante o período que entendemos como de construção do estado nacional, ou seja, entre os anos de1820 e 1850. Os marcos temporais demarcados fazem referência em primeiro lugar ao ano em que D. João VI determinou por meio de carta régia a emancipação política de Sergype e ao ano de 1850, quando em análise da documentação consultada percebemos que houve aumento dos debates no que se refere à instrução. Nesse sentido, utilizamos como nossas principais fontes os Relatórios de Presidentes de Província. Para atingirmos o objetivo proposto no presente trabalho, nos utilizamos dos aportes teórico-metodológicos da História Cultural e da História Política, tendo como base Burke (2008), Gouvea (2008), Dolnikoff (2005) e Carvalho (1980).
Desempenho motor, imagem corporal e bullying escolar
Authors: Silva Saskia Lavyne Barbosa da , Caminha Iraquitan de Oliveira
Published: February 2020

O objetivo desse estudo é analisar a relação entre desempenho motor e imagem corporal no contexto da prática do bullying na escolar, particularmente, no momento do recreio e das aulas de Educação Física. A presente pesquisa tratou de um estudo qualitativo descritivo. O cenario desta investigação foi uma escola pública de ensino fundamental localizada na cidade de Campina Grande. Foram selecionados como sujeitos, crianças, de ambos os sexos, entre sete e doze anos incompletos. Os critérios de exclusão dos sujeitos neste estudo consistiram nos seguintes: a faixa etária superior a 12 anos incompleto e inferior a sete, a negativa dos pais em assinar o TCLE ou, até mesmo a negativa da criança em realizar a entrevista. Para a coleta dos dados foi utilizada uma entrevista semiestruturada e a técnica da observação sistemática. Como resultados, observou-se que há uma relação direta entre o bullying, a imagem corporal e o desempenho motor nas aulas de Educação Física e no recreio.
Primeiras pistas sobre o corpo na escola
Authors: Possato Beatris Cristina
Published: February 2020

Este artigo discursa sobre uma formação realizada com professores de Educação Infantil, Ensino Fundamental e Médio, em um Curso de Extensão. Neste curso foram realizadas oficinas de expressão corporal. A tentativa era sensibilizar os professores para as discussões que se pautavam nas expressões do corpo na escola e como essas interferiam nas práticas escolares. Percebemos que as práticas escolares podem estar pautadas apenas na lógica de uma disciplina autoritária, onde não existem corpos, mas máquinas-pensantes, cujo nível de tensão a que são submetidas poderiam levar os alunos e os professores, muitas vezes, a manifestações violentas. Nessa lógica, o corpo-maquínico-pensante não necessitaria de movimento, não seria sexuado e inserido na instituição escolar, estaria numa realidade diversa da realidade vivida em outras instâncias da sociedade.
Kāyānupassanā: si de yoga budista se trata
Authors: Roach Eduardo Francisco Freyre
Published: February 2020

En este artículo se exploran sutras budistas tempranos (del Canon Pali) donde se expone la práctica del mindfulness, o de la contemplación plena: Satipaţţhāna Sutta, Mahā Satipaţţhāna Sutta, y Ānāpānasati Sutta. Se coloca el énfasis en la práctica yoga Kāyānupassanā (mindfulness del cuerpo), sus variantes y objetivos, fundamentos, y la visión de la corporeidad en que se sustenta. También se le compare con las doctrinas y técnicas yogas que se exponen en el Bhagavad Gita y los Yoga Sutras de Patanjali. Y se muestra como a pesar de su destinación soteriológica, el mindfulness yoga budista esta siendo “aplicado”, no sin algunos riesgos, en el mejoramiento del rendimiento deportivo de los atletas.
Investigações em ensino de Ciências e de Biologia: uma análise a partir das dissertações e teses produzidas no contexto de um grupo de pesquisa
Authors: Pereira Marsílvio Gonçalves , Trivelato Sílvia Luzia Frateschi
Published: February 2020

Neste artigo são analisadas as produções acadêmicas (19 dissertações de mestrado e 11 teses de doutorado) desenvolvidas no Grupo de Estudos e Pesquisas em Ensino de Biologia da Faculdade de Educação da Universidade de São Paulo, no período de 1996 – 2015. A caracterização e classificação dos trabalhos foram feitas com base na leitura dos resumos e na análise de conteúdo. Consideraram-se os seguintes descritores: título do trabalho, o ano de defesa, o autor, as palavras-chave, contexto educacional, nível de ensino, abordagem de pesquisa, instrumentos ou fonte de coleta de dados e tipos de análise dos resultados. As pesquisas analisadas são em grande maioria qualitativas. Têm contemplado alguns conteúdos biológicos em processos de ensino e aprendizagem no ensino fundamental e médio, com temas mais dispersantes no início do grupo evoluindo na atualidade para temas mais concentrados em torno do eixo ‘Linguagem, Cognição e Ensino de Ciências’.
Videogames e projetos didáticos na educação para a saúde
Authors: Dipace Anna , Limone Pierpaolo
Published: February 2020

O artigo pretende salientar que o videogame representa uma atividade que faz bem à saúde pelo menos por dois motivos: promove aprendizagens significativas e favorece o desenvolvimento de estilos de vida saudáveis. O texto traz uma reflexão sobre uma possível revolução didática em que as tecnologias digitais, os videogames se colocam como os principais artefatos a partir dos quais se pode planejar estilos de vida saudável no interior dos contextos escolares. A pesquisa científica no âmbito dos videogames educativos e sua integração no planejamento didático tem sido muito ativa e oferece desafios que a escola não pode ignorar. Os videogames na educação representam um exemplo concreto e inovador na redefinição de ofertas formativas promovidas pelos sistemas escolares. Também representam instrumentos didáticos estratégicos que possibilitam gerir de modo criativo problemas complexos, como o da saúde, visto que estimulam a inteligência e encorajam sua exploração.
Aprendizagem multimídia e conteúdos interativos: uma experiência de pesquisa experimental em Mídia-Educação em escolas de Montevideo
Authors: Serenelli Fabio
Published: February 2020

Este estudo investiga como o uso de objetos de aprendizagem no modelo 1:1 (um artefato por aluno) em escolas pode representar uma solução de mídia-educação significativa e integrada para melhorar a literacia científica e o engajamento dos alunos em contextos críticos. Em 2010 foi realizada uma pesquisa experimental focada no uso de infográficos, animações e interatividade com objetos de aprendizagem digitais no modelo 1:1, envolvendo cerca de 360 adolescentes em diversas turmas de escolas públicas de Montevidéu, Uruguai. Dividiu-se a amostra em 5 grupos e apresentou-se o mesmo conteúdo de 4 maneiras diferentes, modificando o suporte, o ambiente educativo e o formato de instrução de acordo com princípios de Aprendizagem Multimídia de Mayer e os Primeiros Princípios de Instrução de David Merrill. Os resultados obtidos pelos quatro grupos experimentais foram comparados com o desempenho de um grupo de controle que participou de uma aula expositiva ministrada por um professor. A fim de avaliar o impacto das condições experimentais, foram aplicados quatro testes: Retenção, Compreensão, Teste de Resolução de Problemas, e re-Teste de Resolução de Problemas após uma semana. Também foi utilizada uma ferramenta qualitativa e um questionário auto-administrado para verificar 7 parâmetros de Experiência do Usuário. O recorte desse trabalho também inclui um relato pedagógico da pesquisa para melhor contextualizar a metodologia.
Institucionalização dos estudos de gênero na universidade: uma análise a partir de narrativas de acadêmicas feministas
Authors: Morais Adenilda Bertoldo Alves de , Carvalho Maria Eulina Pessoa de
Published: February 2020

Este texto analisa, através das narrativas de três acadêmicas feministas de uma universidade federal nordestina, suas contribuições para a institucionalização dos estudos de gênero. Utilizam-se como categorias de análise: instituição, identidade feminista, narrativa e gênero. A análise evidencia que foi possível trazer os estudos de gê- nero para a universidade investigada através da militância das professoras entrevistadas. Os estudos de gênero são vistos como menos importantes e se inserem através de grupos independentes. As professoras lutam por reconhecimento, ora isoladamente, ora conjuntamente.
Pengembangan Pengembangan Lembar Kerja Peserta Didik Berbasis Inkuiri Terbimbing untuk Meningkatkan Kemampuan Multirepresentasi pada Materi Hukum II Newton
Authors: Sitopu Putri Theresia , Abdurrahman Abdurrahman , Herlina Kartini
Published: February 2020

Tujuan dari penelitian ini adalah mengembangkan LKPD berbasis inkuiri terbimbing untuk meningkatkan kemampuan multirepresentasi peserta didik. Metode penelitian yang digunakan terdiri dari analyze, design, development. Teknik analisis data dilakukan dengan menggunakan data campuran (mix method). Hasil penelitian menunjukkan LKPD berbasis inkuiri terbimbing yang dikembangkan layak digunakan dan mampu meningkatkan kemampuan multirepresentasi peserta didik melalui uji validitas dan uji coba kelompok kecil. Hal tersebut dapat dilihat dari skor uji validitas yang terdiri dari uji ahli materi dan desain. Rata-rata skor yang diperoleh pada uji ahli materi dan uji ahli desain sebesar 3,385 dengan kategori sangat valid dan 3,456 dengan kategori sangat valid. Uji kelompok kecil terdiri dari uji keterbacaan dan uji efektivitas. Rata-rata skor pada uji keterbacaan sebesar 3,24 dengan kategori baik. Uji efektivitas dilakukan dengan memberikan soal pretest dan postest dengan indikator soal yang digunakan ialah indikator kemampuan multirepresentasi sehingga diperoleh nilai n-gain sebesar 0,6 dengan kriteria sedang, dan nilai sig. pada uji sample paired t sebesar 0,000 yang artinya terdapat peningkatan kemampuan multirepresentasi setelah menggunakan LKPD berbasis inkuiri terbimbing. Dengan demikian dapat disimpulkan bahwa LKPD berbasis inukiri terbimbing untuk meningkatkan kemampuan multirepresentasi adalah layak digunakan dan dapat dijadikan sebagai bahan ajar.
Pengembangan Model Pembelajaran Outbound pada Pendidikan Jasmani dalam Meningkatkan Kesegaran Jasmani Siswa
Authors: Humaedi Humaedi , Iskandar Hendra , Abduh Ikhwan
Published: February 2020

Tujuan penelitian ini adalah 1) Menjadi media atau model pembelajaran yang dapat digunakan untuk pembelajaran pendidikan jasmani, 2)Melalui media pembelajaran Outbond diharapkan mampu meningkatkan kompetensi kebugaran jasmani siswa. Jenis penelitian yang akan dilakukan adalah jenis penelitian pengembangan (Research and Development (R&D). tahapan penelitian meliputi a) Analisis Kebutuhan, b)Penelitian awal dan pengumpulan informasi, c)Perencanaan pengembangan, d)Pengembangan produk awal, d)Uji lapangan awal (validasi ahli), e)Revisi I, f)Uji coba kelompok kecil, g)Revisi II, h)Uji coba kelompok besar, i)Desiminasi dan implementasi. Berdasarkan hasil penelitian uji tahap kedua didapatkan bahwa hasil perhitungan persentase klasifikasi tingkat kesegaran jasmani siswa dan nilai rata-rata perolehan tes kesegaran jasmani siswa sebesar 11,67 yang apabila di masukkan dalam tabel norma penilaian kesegaran jasmani maka secara umum terlihat bahwa tingkat kesegaran jasmani siswa kelas V SDN Terpadu Madani masih berklasifikasi sedang, namun apabila dilihat jumlah siswa yang berklasifikasi kesegaran jasmani baik telah banyak mengalami perubahan. Sehingga model pembelajaran outbound yang dikembangkan telah baik dan dapat di gunakan dalam pengembangan tingkat kesegaran jasmani siswa.
Problem Based Learning dan Discovery Learning Sebagai Prediktor Berpikir Kreatif
Authors: Lengo Martina Dewi , Djami Jolis Joskar Anderias
Published: February 2020

This research aims to investigate the influence of problem-based learning on creative thinking, the influence of discovery learning to creative thinking, and the simultaneous influence of problem-based learning and discovery learning to creative thinking. This research is explanatory with the processing and discussion of data using quantitative analysis technique. This research will be conducted at SMA Negeri 1 Rote Barat Daya, which is located in Oetefu Hamlet, Rote Barat Daya District, Rote Ndao Regency, East Nusa Tenggara province. The respondents involved in this study amounted to 88 high school students. The questionnaire used was adapted from a problem-based learning environment, inventory discovery of learning, and Torrance test of Creative Thinking (TTCT). The results showed that problem-based learning has no significant influence on creative thinking, discovery Learning has a positive and significant influence on creative thinking, and simultaneous testing of problem-based learning and discovery learning has no significant influence on the creative thinking of SMA Negeri 1 Rote Barat Daya.
Gender, Authority, and Control: Male Invective and the Restriction of Female Ambition in Early Modern Scotland and England, 1583–1616
Authors: Baer-Tsarfati Lisa
Published: February 2020

Sixteenth-century discourse is filled with criticisms about the ambition of women and the proletariat. This article explores the connection between gender, ambition, authority, reputation, and the language of condemnation at the Jacobean court. It argues that the prevailing rhetoric vilifying female ambition reflects contemporaneous anxieties about female dominance and authority. In turn, male invective, libel, and slander, directed toward politically active elite women, represent men’s attempts to re-exert their authority over women perceived to be subverting established hierarchies of power. By tracing the use of invective in letters, court poetry, and moral essays, this paper reveals the ways in which abusive language was used to damage women’s reputations in order to establish and maintain male authority over women and other men in the court of James VI/I.
The impact of IGF1R SNPs on susceptibility to age-related cataract
Authors: Cui Yilei , Yu Xiaoning , Zhang Xin , Tang Yelei , Tang Xiajing , Yang Hao , Ping Xiyuan , Wu Jing , Yin Qinchuan , Zhou Jiayue , Xu Xiayan , Shentu Xingchao
Published: February 2020

The authors have withdrawn this preprint from Research Square
Juvenile Idiopathic Arthritis Fibroblast-like Synoviocytes, through BMP signaling, play a central role in joint growth disturbances
Authors: Simonds Megan , Schlefman Amanda , McCahan Suzanne , Sullivan Kathleen , Rose Carlos , Brescia AnneMarie
Published: February 2020

Background: To examine critical interactions between juvenile idiopathic arthritis synovial fibroblasts (JFLS) and chondrocytes (Ch), and their role in bony overgrowth seen in patients with juvenile idiopathic arthritis (JIA). Methods: Control (CFLS) and JFLS were cultured in media containing recombinant BMP4. Ch were cultured in either CFLS or JFLS conditioned-media. Media supernatants were analyzed by ELISA. RNA was analyzed by ClariomS microarray. Results: As expected, genes expressed in JFLS and CFLS were similar to each other and this expression differed from Ch. JFLS favor BMP ligand gene expression while downregulating TGFβ receptors’ expression. Noggin and chordin, antagonists with high affinity for BMP4, are JFLS- but not Ch-preferred regulators of BMP signaling. Compared to Ch, JFLS overexpress collagen X (COLX), a marker of chondrocyte hypertrophy. Exogenous BMP4 causes JFLS to significantly decrease expression of noggin and collagen II (COL2), a marker of chondrocyte proliferation, and causes overexpression of COLX and alkaline-phosphatase (ALP). Chondrocytes cultured in JFLS-conditioned media (Ch-JFLS) express BMP genes and favor chordin protein expression over other antagonists. Ch-JFLS have significantly increased expression of COL2 and significantly decreased expression of COLX. Conclusions: These data suggest JFLS, in the presence of BMP4, undergo hypertrophy and that JFLS-conditioned media influence chondrocytes to become highly proliferative. To the authors’ knowledge, no prior study has shown that JFLS and chondrocytes play a direct role in the bony overgrowth in joints of patients with JIA and that BMPs or regulation of these growth factors influence the interaction between two prominent synovial cell types.
A non-destructive method to quantify leaf starch content in red clover
Authors: Frey Lea Antonia , Baumann Philipp , Aasen Helge , Studer Bruno , Kölliker Roland
Published: February 2020

Background: Grassland-based ruminant livestock production provides a sustainable alternative to intensive production systems relying on concentrated feeds. However, grassland-based roughage often lacks the energy content required to meet the productivity potential of modern livestock breeds. Forage legumes, such as red clover, with increased starch content could partly replace maize and cereal supplements. However, breeding for increased starch content requires efficient phenotyping methods. This study is unique in evaluating a non-destructive hyperspectral imaging approach to estimate leaf starch content in red clover for enabling efficient development of high starch red clover genotypes.Results: We assessed prediction performance of partial least square regression models (PLSR) and validated model performance with an independent test set. Starch content of the training set ranged from 0.1 to 120.3 mg g-1 DW. The best cross-validated PLSR model explained 56% of the measured variation and yielded a root mean square error (RMSE) of 17 mg g-1 DW. Model performance decreased when applied to the independent test set (RMSE = 29 mg g-1 DW, R2 = 0.36). Different filtering methods did not increase model performance.Conclusion: The non-destructive spectral method presented here, provides a tool to detect large differences in leaf starch content of red clover. Breeding material can be sampled and selected according to their starch content without destroying the plant.
Classical and potential risk factors of cardiovascular disease among Chinese patients with type 2 diabetes mellitus:a cross-sectional study based on Framingham 10-year general cardiovascular disease risk score
Authors: zhang tianyu , Chen Lu , xiang ying , song xuejia , yang xiuxian , qiu xiaohui , qiao zhengxue , pan hui , Yang Yanjie
Published: February 2020

Background : Cardiovascular risk is greatly increased in diabetic patients, and more than 70% of diabetic patients die of cardiovascular disease. Unfortunately, in China, the awareness rate, treatment rate, and control rate of cardiovascular risk in diabetic patients are still far from enough. Identifying and managing cardiovascular disease risk in T2DM patients is particularly important through relevant risk factor management tools.
Methods: In this study, 750 patients with type 2 diabetes were selected from a Grade-A Tertiary Hospital(beds>500)in Harbin, the response rate was 93.6%. We collected general demographic data, dietary status, and laboratory tests for patients, selected NEO Five-Factor Inventory（NEO-FFI）for personality assessment, and used the Framingham 10-year general cardiovascular disease risk score(FRS) . Statistical analysis includes one-way ANOVA,chi-square analysis,Spearman correlation analysis, univariate and multiple regression analysis.
Results: 291 people in the low-risk group, 239 in the Mid-risk group and 172 in the High-risk group. FRS was correlated with Age, SBP, DBP , Duration, TC, LDL-C, TC, regular diet, spicy food intake and open personality
Conclusions: In addition to traditional risk factors, diet and personality may also should be included for cardiovascular disease in people with type 2 diabetes.
Key words: China，T2DM，cardiovascular disease
Relevance of anthropometric measurements as predictors of prevalent diabetes type II - a cross-sectional study
Authors: Hasselgren Anton , Karmacharya Biraj M , Stensdotter Ann-Katrin
Published: February 2020

Background The association of overweight and diabetes mellitus type 2 varies with geographical area and ethnicity, and there is incoherent evidence as to which anthropometric index best predicts prevalent diabetes mellitus type 2 in different populations. The rationale for this study was to contribute to the understanding of how anthropometric indices perform as a screening tool for diabetes mellitus type 2. Hence, the objective was to determine the predictive potential of anthropometric indices to screen prevalent diabetes mellitus type 2 in the Norwegian population.Methods This study used cross-sectional data from the Health Study in Nord-Trøndelag (HUNT) to determine the potential association of waist-to-height ratio, waist-to-hip ratio, waist-circumference and body mass index with prevalent diabetes mellitus type 2 through logistic regression analysis. Receiver Operating Characteristic (ROC) curves were used to determinate the predictive potential of the anthropometric indices. Youden’s index was applied to determinate the optimal cut-off points for each anthropometric index.Results The results suggest that the anthropometric indices performed differently within the Norwegian population with waist-to-hip ratio and waist-to-height ratio being the strongest predictors with (ROC) of 0.746 (0.735 - 0.757) and 0.741(0.730 - 0.752). The predictive potential for the investigated anthropometric indices was generally stronger for women than men.Interpretation When using anthropometric indices to screen prevalent diabetes mellitus type 2, the choice of anthropometric index and cut-off points should be considered based on country and the ethnic characteristics of the population.
Evolution of Gut Microbiome and Metabolome during Stage 1 Necrotizing Enterocolitis: a Case-Control Study
Authors: Brehin Camille , Dubois Damien , Dicky Odile , Breinig Sophie , Oswald Eric , Serino Matteo
Published: February 2020

Background : Necrotizing enterocolitis (NEC) is a devastating condition of the preterm new-born due to multiple factors, including gut microbiota dysbiosis. Since NEC development is poorly understood due to main focus on late stages 2 and 3, we studied the gut microbiota and metabolome evolution of NEC at a very early onset. Results NEC-1 gut microbiota had a higher abundance of Streptococcus (second decade of life) and Staphylococcus (third decade of life) species. NEC-1 children showed a microbiome evolution in the third decade of life being the most divergent and associated to a different metabolomic signature than in healthy children. NEC-1 microbiome had increased glycosaminoglycan degradation and lysosome activity by the first decade of life and was more sensitive to factors such as childbirth, low birth weight and gestational age, than healthy microbiome. NEC-1 fecal metabolome was more divergent by the second month of life. Conclusions: The modifications of gut microbiota and microbiome during NEC-1 development appear more distinguishable by the third decade of life, when compared to healthy children. These data identify a precise window of time (i.e. third decade of life) and provide microbial targets to fight/blunt the progression of NEC by stage 1.
Bio-adsorption of Basic blue dye from aqueous solution onto raw and modified waste ash as economical alternative bio-adsorbent
Authors: Alene Adugna Nigatu , Abate Gietu Yirga , Habte Adere Tarekegne
Published: February 2020

Background : Dyes are one of the most hazardous material in industrial effluents which can cause several health problems in bio-life. The removal of dye from colored effluents has been attracted increasing attention in the recent decay. In this study raw, beneficiated and activated waste ash was evaluated as an adsorbent for removal of methylene blue (MB) from aqueous solution by batch adsorption method. Comprehensive characterization studies were carried out on each bio-adsorbents such as proximate analyses, bulk density, specific surface area, point of zero charge, pH and Fourier-Transform Infrared (FTIR) spectroscopy (which shows functional groups on adsorbents surface). Results : The effects of pH, adsorbent dosage, initial dye concentration, and contact time were determined in order to know the optimum condition and adsorption potential of the adsorbents. The methylene blue (MB) removal efficiency of raw, beneficiated and activated bio-adsorbents from aqueous solutions was recorded to be 95.212%, 89.172%, and 84.504%, respectively. It is reported that adsorption efficiency of MB on each adsorbents was quite different due to electrostatic and dispersion interaction between the dye molecules and the surface property of the adsorbents. The obtained results were well fitted with Freundlich isotherm model and adsorption process follows the pseudo second order kinetics model for both adsorbents. Conclusions : In fact the results showed that raw, beneficiated and activated waste ash bio-adsorbents could be employed as effective and economical alternative material in the near future use. Key words : Bio-adsorption, waste ash, adsorption capacity, surface modification, basic blue dye.
Studying Students' Knowledge of the Benefits, Challenges, and Applications of Big Data Analytics In Healthcare
Authors: Nazari Elham , Khodabandeh Maryam Edalati , Dadashi Ali , Rasoulian Marjan , tabesh hamed
Published: February 2020

Introdution Today, with the advent of technologies and the production of huge amounts of data, Big Data analytics has received much attention especially in healthcare. Understanding this field and recognizing its benefits, applications and challenges provide useful background for conducting efficient research. Therefore, the purpose of this study was to evaluate the students' familiarity from different universities of Mashhad with the benefits, applications and challenges of Big Data analysis.Method This is a cross-sectional study that was conducted on students of Medical Engineering, Medical Informatics, Medical Records and Health Information Management in Mashhad-Iran. A questionnaire was designed based on literature review in pubmed, google scholar, science direct and EMBASE databases, using Delphi method and presence of 10 experts from different fields of study. The designed questionnaire evaluated the opinion of students regarding benefits, challenges and applications of Big Data analytics. 200 students participated in the study and completed the designed questionnaire. Participants' opinions were evaluated descriptively and analytically. Result Most students were between 20 and 30 years old. 63% of them were male and 43.5% had no work experience. Current and previous field of study of most of the students were HIT, HIM, and Medical Records. Most of the participants in this study were undergraduates. 61.5% were economically active, 54.5% were exposed to Big Data. The mean scores of participants in benefits, applications, and challenges section were 3.71, 3.68, and 3.71, respectively, and process management was significant in different age groups (p=0.046), information, modeling, research, and health informatics across different fields of studies were significant (p=0.015, 0.033, 0.001, 0.024) Information and research were significantly different between groups (p=0.043 and 0.019), research in groups with / without economic activity was significant (p= 0.017) and information in exposure / non exposure to Big Data groups was significant (p=0.02). Conclusion Despite the importance and benefits of Big Data analytics, students' lack of familiarity with the necessity and importance of these analytics in industries and research is significant. The field of study and level of study do not appear to have an effect on the degree of knowledge of individuals regarding Big Data analysis. The design of technical training courses in this field may increase the level of knowledge of individuals regarding Big Data analysis.
Evaluation for Photosynthetic Characteristics in upland cotton germplasm based on chlorophyll a fluorescence
Authors: sun ying , Xu Xiaoming , Dong Wenqing , Du Xiongming , Jia Yinhua , Tang Canming
Published: February 2020

Background: The research of photosynthetic characteristics of germplasm resources of cotton ( Gossypium hirsutum L.) provides reference for genetic improvement on cotton cultivars. Chlorophyll a fluorescence (CF) is widely used for analysis of photosynthetic activity of plants leaves. However, large number of Chlorophyll a fluorescence parameters (CFPs) and inconsistency CFPs application in different studies confuse researchers, which greatly limit the accuracy of photosynthesis analysis. In this study, all 53 CFPs of 189 upland cotton cultivars (strains) measured by handy PEA were screened at 12:00 and 17:00 separately. Results: 9 CFPs including PI(abs), DIo/CSo, PI(abs, total), Sm/T, Vj, Eto/CSo, REo/CSo, RC/CSo and N at 12:00 and 8 CFPs including PI(abs, total), PI(abs), DIo/CSo, Sm/T, REo/CSo, N, Vj and Eto/CSo at 17:00 are suitable for screening of upland cotton cultivars (strains). The screened CFPs classify and evaluate the photosynthetic characteristics of upland cotton cultivars (strains). Conclusions: CFPs selected can be effect and consistent parameters to evaluate photosynthetic activity of cotton germplasm.
Can red cell distribution width and hemoglobin level variations be utilized to predict the prognosis of Stage III operative colorectal cancer patients with adjuvant chemotherapy treatment?
Authors: Li Jie , Rui Yuan-Yi , Song Bo , Zhang Ke , Yi Bo , Zhou Ying , Zheng Yang-Chun
Published: February 2020

Background: The aim of this study was to find that if the red cell distribution width (RDW) or hemoglobin (Hb) level variations had prognostic value in stage III colorectal cancer patients treated with operation and adjuvant chemotherapy.
Methods: One hundred and twenty-two patients were included in this retrospective study. All were diagnosed and re-staged as stage III colorectal cancer in Sichuan Cancer Hospital according to the AJCC Cancer Staging Manual, 8 th edition, 2018. The patients received R0 resection before adjuvant chemotherapy. The baseline information, routine blood examination data, pathological outcome and prognostic stature was retracted from the database. Receiver operating characteristic (ROC) curve analysis was utilized to determine the cut-off value, while the survival analyses were performed with Kaplan-Meier curve, the log-rank test and the Cox regression analysis.
Results: The chemotherapy-associated hemoglobin change (change between the pre- and post-chemotherapy hemoglobin levels) was identified to be associated with the metastasis (P=0.030). The optimal cut-off point was calculated to be -9.5 by the ROC curve of the hemoglobin change, while the area under the curve was 0.648 (95% CI: 0.524-0.772). The results showed that patients with larger hemoglobin decrease had significantly worse disease free survival (DFS) than those with smaller decrease (P=0.020). Factors associated with DFS in uni-variate COX regression analysis were the number of harvested lymph nodes (P=0.040) and the perineural invasion (P=0.020). The peri-chemotherapy change of hemoglobin level was estimated to have significant effect on patient survival (P=0.010).
Conclusions: We concluded that chemotherapy-associated Hb change (change between the pre- and post-chemotherapy) was a DFS prognostic factor for the stage III colorectal cancer patients who underwent operation and adjuvant chemotherapy.
Hepatocellular carcinoma with right atrial tumor thrombus: a meta-analysis
Authors: Yuan Shi-Min , Guo Yi-Xian
Published: February 2020

Background: Hepatocellular carcinoma with right atrial tumor thrombus is uncommon but with a dismal prognosis.
Methods: By comprehensive retrieval of the pertinent literature published since 2000, 53 reports were collected with 187 patients recruited into this study. The quantitative data were expressed in mean±standard deviation with range and median values and were compared by independent samples t -test. The categorical variables were compared by Chi-square or Fisher exact test with continuity correction.
Results: The survival rate of patients receiving transarterial chemoembolization was 33.3% and that of surgical patients was 41.9%. The survival time of patients with transarterial chemoembolization treatment was longer than that of surgical patients, but lack of a statistical significance.
Conclusions: Even though advanced hepatocellular carcinoma with right atrial thrombus is an aggressive malignancy, the the present study showed that patient prognoses were improved and survival time was elongated with the advances of active treatments such as transarterial chemoembolization and surgical treatments. Active treatments are advised to patients with hepatocellular carcinoma with right atrial tumor thrombus in order to improve patients’ survival.
Evaluation of primary care services in Hungary
Authors: Rurik Imre , Jancsó Zoltán , Kalabay László , Lánczi Levente , Mester Lajos , Móczár Csaba , Nánási Anna , Semanova Csilla , Schmidt Péter , Szidor Judit , Tamás Hajnalka , Torzsa Peter , Ungvári Tímea , Végh Mária , Vraukó Katalin , Kolozsvári László
Published: February 2020

Background. It is a major challenge to show what configurations of primary care(PC) is associated with better outcomes, in terms of quality, equity and costs. The QUALICOPC Study tried to analyse and compare them within 35 countries, using validated questionnaires filled by family physicians/general practitioners (GPs). This paper aims to provide data of the Hungarian-arm of the QUALICOPC Study; to compare some findings to that of other participating countries; to give a comprehensive overview about the recent Hungarian PC system. Methods. Altogether 222 questionnaires were completed by Hungarian GPs, delivered by fieldworkers, in a geographically representative distribution. Results . Financing are based mostly on capitation, with smaller additional compensatory elements and minor quality incentives. The gate-keeping function is weak, although by referrals, the preference of patients is mostly considered. Communication between PC and specialists is often insufficient. Variety of available devices and equipment’s are appropriate. Single handed practices were 87%. Appointment instead of queuing is a new option and become more popular, mainly among better educated and urban patients. GPs are involved in the management of almost all chronic condition of all generations. Half of them estimate their job as still interesting, burn-out symptoms were rarely found. Among the evaluated process indicators, access, continuity, comprehensiveness and coordination were rated as satisfactory, together with equity among health outcome indicators. Financing is not sufficient, therefore many GPs are involved in other earning activities. The increasing shortage of manpower is a major challenge. Conclusions. In the past 2 decades, there was visible improvement at service level and in economic circumstances. Cooperation and communication between different levels of health care provision should be improved, focusing better to community orientation and to preventive services. There is a need for specific primary care oriented guidelines to define the expected tasks of GPs.
Molecular Mimicry between Zika virus and central nervous system inflammatory demyelinating disorders: the role of NS5 Zika virus epitope and PLP autoantigens
Authors: França Laise Carolina , Fontes-Dantas Fabrícia Lima , Garcia Diogo Gomes , Araújo Amanda Dutra de , Gonçalves João Paulo da Costa , Rêgo Cláudia Cecília da Silva , Silva Elielson Veloso da , Nascimento Osvaldo José Moreira do , Lopes Fernanda Cristina Rueda , Herlinger Alice Laschuk , Aguiar Renato Santana de , Junior Orlando da Costa Ferreira , Figueira Fernando Faria Andrade , Souza Jorge Paes Barreto Marcondes de , Mesquita Joelma Freire De , Alves-Leon Soniza Vieira Vieira
Published: February 2020

Background: Evidences indicate a strong link between Zika virus (ZikV) and neurological complications. Acute myelitis, optic neuritis, polyneuropathy and encephalomyelitis that mimic inflammatory idiopathic demyelination disorders (IIDD) after ZikV infection have been reported in Brazil. In that context, the present study aims to investigate the possible occurrence of molecular mimicry between ZikV antigens and Multiple Sclerosis (MS) autoantigens, the most frequent IIDD of the central nervous system (CNS). Methods: A retrospective cohort study with 305 patients admitted due to suspected arbovirus infection in Rio de Janeiro was performed, all subjects were submitted to neurological examination and biological sample was collected for serologic and molecular diagnostic. Bioinformatics tools were used to analyze the peptides shared between ZikV antigens and MS autoantigens. Results: Of 305 patients, twenty-six were positive for ZikV and 4 presented IDD pattern found in MS cases. Sequence homology comparisons by bioinformatics approach between NS5 ZikV (most common strains) and PLP MS protein revealed a homology of 5/6 consecutive amino acids (CSSVPV/CSAVPV) with 83% identity, deducing a molecular mimicry. In addition, analysis of the 3D structures of both proteins revealed a similar conformation with alpha helix presentation. Conclusions: Molecular mimicry between NS5 Zika virus antigen and PLP MS autoantigens emerge as a possible mechanism for IDD spectrum in genetically susceptible individuals.
Association between Peer Education and HIV Testing Among Student MSM in China: A Cross-Sectional Study
Authors: Li Changping , Wang Xiaomeng , Cui Zhuang , Yu Zeyang , Zhang Honglu , Huang Huijie , Wang Chun , Zhang Tiantian , Yao Tingting , Chen Yang , Song Desheng , Yang Jie , Liu Yuanyuan , Ma Jun
Published: February 2020

Background

HIV prevalence among young men who have sex with men (YMSM) (<25 years old) all over the world varied dramatically from 35.5%(Gambia) to 0.5%(Belgium). In China, by contrast, the HIV prevalence among YMSM was at a low level (5.6%). However, the number of newly diagnosed college students has increased by 30 to 50 percent annually and HIV prevalence among student MSM in China has increased over the past few years, with access to HIV testing and peer education remaining limited. The objective of this study was to examine the relationship between peer education and HIV testing among student MSM in China.

Methods

The cross-sectional study was conducted in Tianjin, China between January 1, 2018 and December 31,2018. 494 student MSM aged 17-24years old were recruited using snowball sampling. Outcome variables were tested and not tested for HIV in the past year. Besides, social demographics, and sex-related behaviors were collected.

Results

The prevalence of HIV infection for the population was 5% (25/494). Overall, 60.5% of student MSM had tested for HIV in the past year, among which 68.9% had received peer education service. Peer education was significantly associated with HIV testing. After adjusting for sociodemographic characteristics, sexual behaviors, knowledge about HIV and STD infection, student MSM who received peer education were more likely to test for HIV [OR=19.751; 95%CI: (8.630,45.202)].

Conclusions

HIV testing coverage among student MSM in China remains suboptimal. Peer education is significantly associated with HIV testing among this population. Government and non-government organizations could consider this alternatively risk-reduction prevention strategy in the future.