bluuebunny/crossref_metadata_2025 huggingface dataset:
UHMWPE Nanocomposite Coatings Reinforced with Alumina (Al2O3) Nanoparticles for Tribological Applications
Authors: Mohammed Abdul Samad
Published: August 2018

Due to a growing demand for protecting metallic components from wear and tear, polymer coatings are being extensively researched and developed as one of the most effective and efficient solutions to reduce friction and wear in demanding tribological applications. The present study focuses on developing a polymer nanocomposite coating of ultra-high molecular polyethylene (UHMWPE) reinforced with different loadings (0.5, 3, 5, and 10 wt %) of alumina to protect steel surfaces. Wear tests were conducted on the coated samples using a tribometer with a ball-on-disk configuration, sliding against a 440C hardened stainless steel ball as a counterface to evaluate the wear life and the load-bearing capacity of the developed coatings. Micro-indentation, energy dispersive X-ray spectroscopy, scanning electron microscopy, and optical profilometry techniques were used to characterize the coatings in terms of hardness, dispersion of the nanofillers, morphology, and wear mechanisms, respectively. Results showed that the UHMWPE nanocomposite coating reinforced with 3 wt % and 5 wt % of alumina did not fail, even until 250,000 cycles at a normal load of 12 N and a linear speed of 0.1 m/s, showing a significant improvement in wear resistance as compared to the pristine UHMWPE coating.
Stress Relaxation Properties and Microscopic Deformation Structure in Bending of the C7025 and C7035 Alloy
Authors: Xiao Xiangpeng , Xu Hai , Huang Jian , Wang Junfeng , Zhang Jianbo
Published: August 2018

Stress relaxation tests in cantilever bending were performed on the C7025 and C7035 alloys at 298 K and 393 K, respectively. The effect of stress-relief treatments on stress relaxation properties was investigated. The structural changes associated with the stress relaxation process were examined using transmission electron microscopy. The stress relaxation curve fits well to empirical formula σ* = [K’ln(t + α0) + C]−n for stress relaxation. The curves can be split into two stages. The stress drops fast at first and then it gets slower in the second stage, and tends towards a certain limited value after a long time. The curve and microstructure reveal that the C7035 alloy has a lower rate of stress relaxation and a higher anti-stress relaxation capacity than the C7025. The first reason is that the movement of vacancies required by spinodal decomposition is inhibited, and the quantity of cobalt-containing vacancies decreases dramatically in the C7035 alloy. The other reason is that the precipitated phases became uniformly diffused in the C7035 alloy. The precipitate phase is uniformly distributed in the grain boundaries and the matrix, during the relaxed condition, and thus the dislocation movement is blocked by the precipitate.
Bird Functional Traits Respond to Forest Structure in Riparian Areas Undergoing Active Restoration
Authors: Batisteli Augusto F. , Tanaka Marcel O. , Souza Andréa L.T.
Published: August 2018

Monitoring wildlife responses is essential to assess restoration projects. Birds are widely used as bioindicators of ecosystem restoration, but most studies use only taxonomic descriptors to compare categories of reference and restoring sites. Here, we used forest structure as a continuous predictor variable to evaluate avifaunal taxonomic and functional indicators in riparian forest reference and restoration sites on southeastern Brazil. Reference sites were riparian forest remnants, and restoration sites were pasture before seedling reintroduction. Forest structure variables (mean tree height, canopy depth, mean diameter at breast height, basal area, tree layering, tree density, and grass cover) were reduced into two axes using a Principal Component Analysis (PCA), Forest Axis 1 (tree biomass vs. grass cover) and Forest Axis 2 (canopy depth vs. tree density). Bird species were classified in relation to five functional categories (i.e., diet, foraging stratum, nest height, cavity dependence for nesting, and forest dependence). Forest Axis 1 influenced the functional diversity of bird assemblages and the relative abundance within levels of each functional category (except for nest height). The relative abundance of all functional categories combined was also affected by Forest Axis 2. Therefore, forest structure affected the predominant functional traits of bird species in riparian sites under restoration. Sites with higher tree biomass were the richest, with canopy birds that were insectivores and frugivores of high forest dependence, whereas more open sites were associated with birds of low forest dependence and ground-foraging insectivores. Forest structures of similar-aged sites were strongly variable, due to natural and anthropic disturbances, so restoration age was a poor indicator of forest development. These unpredictable disturbances can change the development of sites under restoration, so that forest structure can be a better descriptor of the trajectory of these ecosystems.
Impact of Information Loss on Reconstruction Quality in Microwave Tomography for Medical Imaging
Authors: Miao Zhenzhuang , Kosmas Panagiotis , Ahsan Syed
Published: August 2018

This paper studies how limited information in data acquired by a wideband microwave tomography (MWT) system can affect the quality of reconstructed images. Limitations can arise from experimental errors, mismatch between the system and its model in the imaging algorithm, or losses in the immersion and coupling medium which are required to moderate this mismatch. We also present a strategy for improving reconstruction performance by discarding data that is dominated by experimental errors. The approach relies on recording transmitted signals in a wide frequency range, and then correlating the data in different frequencies. We apply this method to our wideband MWT prototype, which has been developed in our previous work. Using this system, we present results from simulated and experimental data which demonstrate the practical value of the frequency selection approach. We also propose a K-neighbour method to identify low quality data in a robust manner. The resulting enhancement in imaging quality suggests that this approach can be useful for various medical imaging scenarios, provided that data from multiple frequencies can be acquired and used in the reconstruction process.
Dynamic Routing in Flying Ad-Hoc Networks Using Topology-Based Routing Protocols
Authors: Khan Muhammad Asghar , Khan Inam Ullah , Safi Alamgir , Quershi Ijaz Mansoor
Published: August 2018

The ever-increasing demand for flexible and portable communications has led to a rapid evolution in networking between unmanned aerial vehicles (UAVs) often referred to as flying ad-hoc networks (FANETs). However, due to the exclusive characteristics of UAVs such as high mobility, frequent topology change and 3D space movement, make routing a challenging task in FANETs. Due to these characteristics, designing new routing protocols for FANETs is quite difficult. In the literature study of FANETs, a variety of traditional ad-hoc networking protocols have been suggested and tested for FANETs to establish an efficient and robust communication among the UAVs. In this context, topology-based routing is considered the most significant approach for solving the routing issues in FANETs. Therefore, in this article we specifically focus on topology-based routing protocols with the aim of improving the efficiency of the network in terms of throughput, end-to-end delay, and network load. We present a brief review of the most important topology-based routing protocols in the context of FANETs. We provide them with their working features for exchanging information, along with the pros and cons of each protocol. Moreover, simulation analyses of some of the topology-based routing protocols are also evaluated in terms of end-to-end delay, throughput and network load the using optimized network engineering tools (OPNET) simulator. Furthermore, this work can be used as a source of reference for researchers and network engineers who seek literature that is relevant to routing in FANETs.
Design and Optimization of a Novel Wound Field Synchronous Machine for Torque Performance Enhancement
Authors: Chai Wenping , Lipo Thomas A. , Kwon Byung-il
Published: August 2018

This paper presents the design and optimization of a novel wound field synchronous machine topology, in which permanent magnets (PMs) are introduced into the rotor slot opening with segment configuration for high quality output torque performance. The rotor shape of the proposed PM-assisted wound field synchronous machine with segment configuration is optimized for maximizing the average output torque and decreasing torque ripple under constant PM volume and motor size. The segment configuration can be benefit to improve the reluctance torque. In addition, it is further clarified that the assisted-PM can help to increase the field torque by enlarging the magnetizing synchronous reactance (Xf), as well as increasing airgap flux density. An optimal method combining Kriging method and genetic algorithm is applied for rotor shape optimization of proposed PM-assisted wound field synchronous machine (PMa-WFSM). Then, the 2-D finite-element analysis results, with the aid of JMAG-Designer, are used to confirm the validity. It is determined that the average output torque is improved by 31.66%, and keeps lower torque ripple without decreasing efficiency, increasing PM volume and motor size compared with those of the basic model. Finally, irreversible demagnetization and mises stress analysis verifies the reliability of the novel topology.
Analysis of Propagation Delay for Multi-Terminal High Voltage Direct Current Networks Interconnecting the Large-Scale Off-Shore Renewable Energy
Authors: Nadeem Muhammad Haroon , Zheng Xiaodong , Tai Nengling , Gul Mehr , Tahir Sohaib
Published: August 2018

Voltage-source-converter-based multi-terminal high voltage direct current (MTDC) networks are extensively recognized as a viable solution for meeting the increasing demand of electrical energy and escalating penetration of renewable energy sources. DC faults are major limitations to the development of MTDC networks. The analysis of variable constraints has become mandatory in order to develop a reliable protection scheme. This paper contributes in assessing the propagation delay with the analytical approximation in MTDC networks. The propagation delay is analyzed in the time domain by taking only the forward traveling wave into account and considering the initial voltage step of magnitude at the fault position. Numerous simulations were carried out for different parameters and arrangements in Power System Computer Aided Design (PSCAD) to explore the proposed expressions. The results accurately depicted the time development of fault current. The results obtained from the real-time digital simulator (RTDS) confirmed that the proposed approach is capable of evaluating propagation delay in MTDC networks. Moreover, the influence of fault resistance is also taken into account for investigating its effect on the system parameters.
Carbon Taxes and Carbon Right Costs Analysis for the Tire Industry
Authors: Tsai Wen-Hsien
Published: August 2018

As enterprises are the major perpetrators of global climate change, concerns about global warming, climate change, and global greenhouse gas emissions continue to attract attention, and have become international concerns. The tire industry, which is a high-pollution, high-carbon emission industry, is facing pressure to reduce its carbon emissions. Thus, carbon prices and carbon trading have become issues of global importance. In order to solve this environmental problem, the purpose of this paper is to combine mathematical programming, Theory of Constraints (TOC), and Activity-Based Costing (ABC) to formulate the green production decision model with carbon taxes and carbon right costs, in order to achieve the optimal product mix decision under various constraints. This study proposes three different scenario models with carbon taxes and carbon right used to evaluate the effect on profit of changes in carbon tax rates.
First Report on Establishment of Laricobius osakensis (Coleoptera: Derodontidae), a Biological Control Agent for Hemlock Woolly Adelgid, Adelges tsugae (Hemiptera: Adelgidae), in the Eastern U.S.
Authors: Toland Ashley , Brewster Carlyle , Mooneyham Katlin , Salom Scott
Published: August 2018

The hemlock woolly adelgid (HWA) is an invasive insect species native to Japan causing significant hemlock mortality in the eastern United States. Laricobius spp. have been targeted as biological control agents because they are adelgid specialists. Laricobius osakensis Montgomery and Shiyake is native to the same region of Japan from which the strain of HWA found in the eastern United States originated. Studies in Japan found that it is phenologically synchronous with HWA. Following approval to release L. osakensis from quarantine in 2010, approximately 32,000 were released at a total of 61 sites starting in 2012. In winter of 2014 and 2015, periods of extreme cold temperatures throughout the eastern USA, as well as the polar vortex, resulted in extensive mortality to HWA, which likely delayed the establishment of L. osakensis. The ability of the beetle to survive and establish in the eastern United States is reported here. In the first year of this study (2015–2016), limited numbers of L. osakensis were recovered, as HWA populations were still rebounding. In the second year (2016–2017), 147 L. osakensis were collected at 5 of 9 sites sampled, coinciding with rebounding HWA populations. Larval recovery was much greater than adult recovery throughout the study. HWA density was directly correlated with warmer plant hardiness zones and recovery of Laricobius beetles was significantly correlated with HWA density. Our results suggest that L. osakensis is successfully establishing at several of the sampled release sites and that the best predictor of its presence at a site is the HWA density.
Revealing the True Nature of Hen 2-428
Authors: Reindl Nicole , Finch Nicolle L. , Schaffenroth Veronika , Barstow Martin A. , Casewell Sarah L. , Geier Stephan , Miller Bertolami Marcelo M. , Taubenberger Stefan
Published: August 2018

The nucleus of Hen 2-428 is a short orbital period (4.2 h) spectroscopic binary, whose status as potential supernovae type Ia progenitor has raised some controversy in the literature. We present preliminary results of a thorough analysis of this interesting system, which combines quantitative non-local thermodynamic (non-LTE) equilibrium spectral modelling, radial velocity analysis, multi-band light curve fitting, and state-of-the art stellar evolutionary calculations. Importantly, we find that the dynamical system mass that is derived by using all available He II lines does not exceed the Chandrasekhar mass limit. Furthermore, the individual masses of the two central stars are too small to lead to an SN Ia in case of a dynamical explosion during the merger process.
Protein Import into the Endosymbiotic Organelles of Apicomplexan Parasites
Authors: Mallo Natalia , Fellows Justin , Johnson Carla , Sheiner Lilach
Published: August 2018

The organelles of endosymbiotic origin, plastids, and mitochondria, evolved through the serial acquisition of endosymbionts by a host cell. These events were accompanied by gene transfer from the symbionts to the host, resulting in most of the organellar proteins being encoded in the cell nuclear genome and trafficked into the organelle via a series of translocation complexes. Much of what is known about organelle protein translocation mechanisms is based on studies performed in common model organisms; e.g., yeast and humans or Arabidopsis. However, studies performed in divergent organisms are gradually accumulating. These studies provide insights into universally conserved traits, while discovering traits that are specific to organisms or clades. Apicomplexan parasites feature two organelles of endosymbiotic origin: a secondary plastid named the apicoplast and a mitochondrion. In the context of the diseases caused by apicomplexan parasites, the essential roles and divergent features of both organelles make them prime targets for drug discovery. This potential and the amenability of the apicomplexan Toxoplasma gondii to genetic manipulation motivated research about the mechanisms controlling both organelles’ biogenesis. Here we provide an overview of what is known about apicomplexan organelle protein import. We focus on work done mainly in T. gondii and provide a comparison to model organisms.
Protein Intake during the First Two Years of Life and Its Association with Growth and Risk of Overweight
Authors: Tang Minghua
Published: August 2018

Growth patterns early in life could exert a long-term impact on overweight and obesity development. Among all potential manipulative factors, infant diet is one of the most influential and could affect growth and subsequent health status during adolescence and adulthood. Dietary protein, as an important macronutrient in infants’ diet, has been of special interest to researchers. Compared with human milk, infant formula tends to have a higher protein content and is associated with greater weight gain and later-in-life obesity risk. However, the effect of protein from other sources on infant growth trajectories during complementary feeding is not clear. Emerging research suggests that meat protein during early complementary feeding promotes linear growth while not increasing risk of overweight compared with dairy protein; and the gut microbiota might be a mediator between protein quality and growth trajectories. This review addresses the current knowledge of protein intake from birth to 24 months and its relationship with growth and risk of overweight.
The Characterization of Arabidopsis mterf6 Mutants Reveals a New Role for mTERF6 in Tolerance to Abiotic Stress
Authors: Robles Pedro , Navarro-Cartagena Sergio , Ferrández-Ayela Almudena , Núñez-Delegido Eva , Quesada Víctor
Published: August 2018

Exposure of plants to abiotic stresses, such as salinity, cold, heat, or drought, affects their growth and development, and can significantly reduce their productivity. Plants have developed adaptive strategies to deal with situations of abiotic stresses with guarantees of success, which have favoured the expansion and functional diversification of different gene families. The family of mitochondrial transcription termination factors (mTERFs), first identified in animals and more recently in plants, is likely a good example of this. In plants, mTERFs are located in chloroplasts and/or mitochondria, participate in the control of organellar gene expression (OGE), and, compared with animals, the mTERF family is expanded. Furthermore, the mutations in some of the hitherto characterised plant mTERFs result in altered responses to salt, high light, heat, or osmotic stress, which suggests a role for these genes in plant adaptation and tolerance to adverse environmental conditions. In this work, we investigated the effect of impaired mTERF6 function on the tolerance of Arabidopsis to salt, osmotic and moderate heat stresses, and on the response to the abscisic acid (ABA) hormone, required for plants to adapt to abiotic stresses. We found that the strong loss-of-function mterf6-2 and mterf6-5 mutants, mainly the former, were hypersensitive to NaCl, mannitol, and ABA during germination and seedling establishment. Additionally, mterf6-5 exhibited a higher sensitivity to moderate heat stress and a lower response to NaCl and ABA later in development. Our computational analysis revealed considerable changes in the mTERF6 transcript levels in plants exposed to different abiotic stresses. Together, our results pinpoint a function for Arabidopsis mTERF6 in the tolerance to adverse environmental conditions, and highlight the importance of plant mTERFs, and hence of OGE homeostasis, for proper acclimation to abiotic stress.
In Vivo Irradiation of Mice Induces Activation of Dendritic Cells
Authors: Persa Eszter , Szatmári Tünde , Sáfrány Géza , Lumniczky Katalin
Published: August 2018

It is becoming clear that ionizing radiation positively influences certain immune parameters, which opens the possibility for combining radio- and immunotherapies in cancer treatment. The presence of functionally competent dendritic cells (DCs) is crucial in mounting a successful antitumor immune response. While it has been shown that DCs are relatively radioresistant, few and contradictory data are available on how ionizing radiation alters the functional integrity of these cells. Therefore, our objective was to investigate the effect of whole-body irradiation on the function of splenic DCs. C57Bl/6 mice were irradiated with 0.1, 0.25, and 2 Gy X-rays and changes in the phenotype of splenic DCs were compared to unirradiated controls. An increase was seen in DC surface markers influencing DC-T cell interactions. In vivo cytokine production was determined by direct intracellular cytokine staining. Irradiation with 2 Gy induced a 1.6-fold increase in IL-1α production, while the combination of irradiation and lipopolysaccharide (LPS) treatment induced a 3.9-fold increase, indicating a strong synergism between irradiation and LPS stimulation. Interaction of DCs with effector and regulatory T cells was investigated in a mixed lymphocyte reaction. While DCs from control animals induced stronger proliferation of regulatory T cells, DCs from animals irradiated with 2 Gy induced stronger proliferation of effector T cells. Antigen uptake and presentation was investigated by measuring the capacity of DCs to internalize and present ovalbumine (OVA)-derived peptides on their major histocompatibility complex (MHCI) molecules. Irradiation with 2 Gy did not influence antigen uptake or presentation, while low doses stimulated antigen uptake and reduced the level of antigen presentation. In conclusion, high-dose in vivo irradiation induced increased expression of T cell costimulatory markers, enhanced production of proinflammatory cytokines and a stronger stimulation of effector T cell proliferation than that of regulatory T cells. However, it did not influence DC antigen uptake or presentation. On the other hand, low-dose irradiation increased antigen uptake and lowered antigen presentation of DCs, indicating that low- and high-dose irradiation act on different pathways in DCs.
Comparative Metagenomic Analysis of Rhizosphere Microbial Community Composition and Functional Potentials under Rehmannia glutinosa Consecutive Monoculture
Authors: Wu Linkun , Wang Juanying , Wu Hongmiao , Chen Jun , Xiao Zhigang , Qin Xianjin , Zhang Zhongyi , Lin Wenxiong
Published: August 2018

Consecutive monoculture of Rehmannia glutinosa, highly valued in traditional Chinese medicine, leads to a severe decline in both quality and yield. Rhizosphere microbiome was reported to be closely associated with the soil health and plant performance. In this study, comparative metagenomics was applied to investigate the shifts in rhizosphere microbial structures and functional potentials under consecutive monoculture. The results showed R. glutinosa monoculture significantly decreased the relative abundances of Pseudomonadaceae and Burkholderiaceae, but significantly increased the relative abundances of Sphingomonadaceae and Streptomycetaceae. Moreover, the abundances of genera Pseudomonas, Azotobacter, Burkholderia, and Lysobacter, among others, were significantly lower in two-year monocultured soil than in one-year cultured soil. For potentially harmful/indicator microorganisms, the percentages of reads categorized to defense mechanisms (i.e., ATP-binding cassette (ABC) transporters, efflux transporter, antibiotic resistance) and biological metabolism (i.e., lipid transport and metabolism, secondary metabolites biosynthesis, transport and catabolism, nucleotide transport and metabolism, transcription) were significantly higher in two-year monocultured soil than in one-year cultured soil, but the opposite was true for potentially beneficial microorganisms, which might disrupt the equilibrium between beneficial and harmful microbes. Collectively, our results provide important insights into the shifts in genomic diversity and functional potentials of rhizosphere microbiome in response to R. glutinosa consecutive monoculture.
Comprehensive Analysis of Codon Usage on Rabies Virus and Other Lyssaviruses
Authors: Zhang Xu , Cai Yuchen , Zhai Xiaofeng , Liu Jie , Zhao Wen , Ji Senlin , Su Shuo , Zhou Jiyong
Published: August 2018

Rabies virus (RABV) and other lyssaviruses can cause rabies and rabies-like diseases, which are a persistent public health threat to humans and other mammals. Lyssaviruses exhibit distinct characteristics in terms of geographical distribution and host specificity, indicative of a long-standing diversification to adapt to the environment. However, the evolutionary diversity of lyssaviruses, in terms of codon usage, is still unclear. We found that RABV has the lowest codon usage bias among lyssaviruses strains, evidenced by its high mean effective number of codons (ENC) (53.84 ± 0.35). Moreover, natural selection is the driving force in shaping the codon usage pattern of these strains. In summary, our study sheds light on the codon usage patterns of lyssaviruses, which can aid in the development of control strategies and experimental research.
Application of Fluorescence Lifetime Imaging Microscopy of DNA Binding Dyes to Assess Radiation-Induced Chromatin Compaction Changes
Authors: Abdollahi Elham , Taucher-Scholz Gisela , Jakob Burkhard
Published: August 2018

In recent years several approaches have been developed to address the chromatin status and its changes in eukaryotic cells under different conditions—but only few are applicable in living cells. Fluorescence lifetime imaging microscopy (FLIM) is a functional tool that can be used for the inspection of the molecular environment of fluorophores in living cells. Here, we present the use of single organic minor groove DNA binder dyes in FLIM for measuring chromatin changes following modulation of chromatin structure in living cells. Treatment with histone deacetylase inhibitors led to an increased fluorescence lifetime indicating global chromatin decompaction, whereas hyperosmolarity decreased the lifetime of the used dyes, thus reflecting the expected compaction. In addition, we demonstrate that time domain FLIM data based on single photon counting should be optimized using pile-up and counting loss correction, which affect the readout even at moderate average detector count rates in inhomogeneous samples. Using these corrections and utilizing Hoechst 34580 as chromatin compaction probe, we measured a pan nuclear increase in the lifetime following irradiation with X-rays in living NIH/3T3 cells thus providing a method to measure radiation-induced chromatin decompaction.
Contingency Contracts for Weight Gain of Patients with Anorexia Nervosa in Inpatient Therapy: Practice Styles of Specialized Centers
Authors: Ziser Katrin , Giel Katrin E. , Resmark Gaby , Nikendei Christoph , Friederich Hans-Christoph , Herpertz Stephan , Rose Matthias , De Zwaan Martina , Von Wietersheim Jörn , Zeeck Almut , Dinkel Andreas , Burgmer Markus , Löwe Bernd , Sprute Carina , Zipfel Stephan , Junne Florian
Published: August 2018

The treatment of patients with anorexia nervosa (AN) is often challenging, due to a high degree of ambivalence towards recovery and weight gain these patients often express. One part of the multimodal treatment is the utilization of treatment contracts (i.e., contingency contracts) that aim to motivate patients to gain weight by applying positive and negative consequences for the (non-)achievement of weight goals. The main aim of this study is to assess and analyze current standards of contingency contracts’ utilization in German eating disorder centers. n = 76 mental health professionals of twelve specialized university centers in Germany that are currently or were formerly treating patients with AN in an inpatient setting participated. Most experts use contingency contracts in their clinic with weekly weight goals ranging between 500 and 700 g. Overall effectiveness and significance of contingency contracts for the inpatient treatment of patients with AN was rated high. Typical characteristics of a contingency contract in specialized German university hospital centers, such as the most frequent consequences, are described. The survey results assist the planning of further studies aiming to improve the multimodal treatment of patients with AN. For clinical practice, using external motivators such as contingency contracts as well as targeting internal motivation (e.g., by using motivational interviewing) is proposed.
Ventriculoperitoneal Shunts Equipped with On-Off Valves for Intraventricular Therapies in Patients with Communicating Hydrocephalus due to Leptomeningeal Metastases
Authors: Burger Michael , Wagner Marlies , Franz Kea , Harter Patrick , Bähr Oliver , Steinbach Joachim , Senft Christian
Published: August 2018

Ventriculoperitoneal shunts equipped with a reservoir and a valve to manually switch off the shunt function can be used for intraventricular injections of therapeutics in patients suffering from a communicating hydrocephalus caused by leptomeningeal metastases. These shunt devices avoid the risk of injecting therapeutics through the distal leg of the shunt system into the intraperitoneal space, which may cause toxicity. Furthermore, regular intraventricular injections of chemotherapeutics help to maintain sufficient concentrations in the ventricular space. Therefore, ventriculoperitoneal shunts equipped with an on-off valve are a useful tool to reliably inject chemotherapeutics into the ventricles. In order to systematically assess feasibility, safety, and efficacy of this procedure, we performed a retrospective analysis of all patients with leptomeningeal metastases who had received a shunt system at our institution. In total, six adult patients had a ventriculoperitoneal shunt equipped with an on-off valve implanted. Out of these six patients, two patients subsequently received intraventricular injections of chemotherapeutics. The configuration of the valve setting and the intraventricular injections were easily feasible in the setting of a neuro-oncology department. The complication of a shunt leakage occurred in one patient following the first intraventricular injection. No extra-central nervous system (CNS) toxicities were observed. In summary, ventriculoperitoneal shunts with on-off valves are useful tools for reliable intraventricular administration of therapeutics.
Towards Changing Compulsory Community Mental Health Treatment in New Zealand: Shining Light on How Community Treatment Orders Are Produced
Authors: Schneller Alison , Thom Katey , Adams Peter
Published: August 2018

In this paper, we use a constructed scenario to illustrate making a compulsory community treatment order in the New Zealand context. Drawing on publicly available documentation, we outline the existing mental health law framework that produces community treatment orders and emerging complex problems of their high, increasing and disproportionate use. We provide examples of human rights, indigenous and clinical effectiveness research that appear to be destabilising the existing mental health law framework. We argue assemblage theory (Deleuze & Guattari) is a useful theoretical tool to unpack the making and continued use of compulsory community treatment orders in the context of complex destabilising and stabilising influences. This is followed by an outline of the concept of assemblage with reference to the constructed scenario, focusing on processes, practices, places, types of knowledge, roles, documents and how they connect to produce certain effects that both enable and constrain participants’ actions. In the New Zealand context, we examine the potential for assemblage theory to generate new ways of thinking about compulsory mental health treatment in community settings by challenging perceived limitations and revealing opportunities for participants to act otherwise. We conclude with a proposal for further research shaped by this theory that explores the making of actual community treatment orders to reveal where there is potential to change existing relations towards more positive effects for participants.
Microbending Experiments on Pure Magnesium with Nonbasal Slip Orientation
Authors: Maňák Jan , Vokoun David
Published: August 2018

In the present study, in situ microbending experiments on magnesium single crystalline microcantilevers are presented. Microcantilevers with pentagonal cross-section were fabricated by focus ion beam. Two basic crystallographic orientations of the microcantilevers were investigated: {0001} and {10-10}, i.e., the c-axis perpendicular to and parallel with the cantilever top surface, respectively. After bending, the longitudinal sections of the microcantilevers were analyzed using electron backscatter diffraction to investigate the crystal lattice rotations and accumulated deformations. The stress levels in the loaded cantilevers are strongly dependent on the crystal orientation. Extension twins were found in the {10-10} cantilevers.
Causality Effects of Interventions and Stressors on Driving Behaviors under Typical Conditions
Authors: Gomez Juan Pablo , Akleman Derya , Akleman Ergun , Pavlidis Ioannis
Published: August 2018

In this paper, we demonstrate that interventions and stressors do not necessarily cause the same distractions in all people; therefore, it is impossible to evaluate the impacts of interventions and stressors on traffic accidents. We analyzed publicly available multimodal data that was collected through one of the largest controlled experiments on distracted driving. A crossover design was used to examine the effects of actual and perceived interventions and stressors in driving behaviors and parallel designs on reactivity to a startling event. To analyze this data and make recommendations, we developed and compared a wide variety of mixed effects statistical models and machine learning methods to evaluate the effects of interventions and stressors on driving behaviors.
Set Evincing the Ranks with Respect to an Embedded Variety (Symmetric Tensor Rank and Tensor Rank
Authors: Ballico Edoardo
Published: August 2018

Let X ⊂ P r be an integral and non-degenerate variety. We study when a finite set S ⊂ X evinces the X-rank of the general point of the linear span of S. We give a criterion when X is the order d Veronese embedding X n , d of P n and | S | ≤ ( n + ⌊ d / 2 ⌋ n ) . For the tensor rank, we describe the cases with | S | ≤ 3 . For X n , d , we raise some questions of the maximum rank for d ≫ 0 (for a fixed n) and for n ≫ 0 (for a fixed d).
The Effect of Tellurium on the Formation of MnTe-MnS Composite Inclusions in Non-Quenched and Tempered Steel
Authors: Shen Ping , Yang Qiankun , Zhang Dong , Yang Shufeng , Fu Jianxun
Published: August 2018

Te is a seldom-used alloying element, which is mainly used in free-machining steel. The Te content in this kind of steel is relatively low, and only a small amount of MnTe is generated. In previous studies, the effect of Te on the formation of inclusions was not fully studied. In order to clarify the mechanism, different amounts of tellurium were added into 38MnVS6 steel to form a certain amount of MnTe. The MnTe wrapped the MnS, forming a composite inclusion. With the increase of Te content in the steel, the diameter of inclusion increased, while the aspect ratio of inclusion varied little. The aspect ratio of most inclusions was in the range of 1~3. Besides, the MnS in the MnTe-MnS composite inclusions gradually changed from one big particle to several small particles. The solidification of the steel, as well as the precipitation of MnS and MnTe, was the main factor that affecting the formation of the composite inclusion. The mechanism of the process was systematically expressed in the current study.
Chemical Composition of Mn- and Cl-Rich Apatites from the Szklary Pegmatite, Central Sudetes, SW Poland: Taxonomic and Genetic Implications
Authors: Szuszkiewicz Adam , Pieczka Adam , Gołębiowska Bożena , Dumańska-Słowik Magdalena , Marszałek Mariola , Szełęg Eligiusz
Published: August 2018

Although calcium phosphates of the apatite group (apatites) with elevated contents of Mn are common accessory minerals in geochemically evolved granitic pegmatites, their Mn-dominant analogues are poorly studied. Pieczkaite, M1Mn2M2Mn3(PO4)3XCl, is an exceptionally rare Mn analogue of chlorapatite known so far from only two occurrences in the world, i.e., granitic pegmatites at Cross Lake, Manitoba, Canada and Szklary, Sudetes, SW Poland. In this study, we present the data on the compositional variation and microtextural relationships of various apatites highly enriched in Mn and Cl from Szklary, with the main focus on compositions approaching or attaining the stoichiometry of pieczkaite (pieczkaite-like apatites). The main goal of this study is to analyze their taxonomical position as well as discuss a possible mode of origin. The results show that pieczkaite-like apatites represent the Mn-rich sector of the solid solution M1(Mn,Ca)2M2(Mn,Ca)3(PO4)3X(Cl,OH). In the case of cation-disordered structure, all these compositions represent extremely Mn-rich hydroxylapatite or pieczkaite. However, for cation-ordered structure, there are also intermediate compositions for which the existence of two hypothetical end-member species can be postulated: M1Ca2M2Mn3(PO4)3XCl and M1Mn2M2Ca3(PO4)3XOH. In contrast to hydroxylapatite and pieczkaite, that are members of the apatite-group, the two hypothetical species would classify into the hedyphane group within the apatite supergroup. The pieczkaite-like apatites are followed by highly Mn-enriched fluor- and hydroxylapatites in the crystallization sequence. Mn-poor chlorapatites, on the other hand, document local contamination by the serpentinite wall rocks. We propose that pieczkaite-like apatites in the Szklary pegmatite formed from small-volume droplets of P-rich melt that unmixed from the LCT-type (Li–Cs–Ta) pegmatite-forming melt with high degree of Mn-Fe fractionation. The LCT melt became locally enriched in Cl through in situ contamination by wall rock serpentinites.
Characteristics of Biologically Active Compounds in Cornelian Cherry Meads
Authors: Adamenko Kinga , Kawa-Rygielska Joanna , Kucharska Alicja Z. , Piórecki Narcyz
Published: August 2018

In this study, we investigated the effect of Cornelian cherry cultivars differing in fruit color (“Yantaryi”—yellow fruits, “Koralovyi”—coral fruits, “Podolski”—red fruits) on physicochemical characteristics, antioxidative properties, and contents of iridoids and polyphenols in meads with the addition of juices made of their fruits. “Trójniak” type meads (1:2 honey to water volume) were manufactured from multifloral honey, to which Cornelian cherry fruit juice was added before fermentation. Concentrations of individual iridoids and polyphenols were determined using HPLC analysis with a thermostat refractometric detector, model RID-10A. The total polyphenol content was determined based on testing with Folin–Ciocalteu (F-C) reagent, whereas the antioxidative properties were determined using DPPH• (2,2-Diphenyl-2-picryl-hydrazyl), ABTS•⁺ (2,2′-Azino-bis(3-ethylbenzo-thiazoline-6-sulfonic acid), and FRAP (ferric reducing antioxidant power) assays. Cultivar of Cornelian cherry fruits influenced both the antioxidative properties and the concentrations of polyphenols and iridoids. The highest concentration of total polyphenols (F-C), accounting for 898.7 mg gallic acid (GAE)/L, was determined in the mead with juice made of red fruits; this mead was also characterized by the strongest antioxidative capabilities measured with ABTS•⁺ and FRAP assays. Among the iridoids determined in the Cornelian cherry meads, loganic acid was found to prevail and its highest concentration, reaching 77.8 mg loganic acid (LA)/L mead, was determined in the mead with the coral-fruit juice. Study results indicate that Cornelian cherry meads have a high content of biologically active iridoids and phenolic acids which display valuable antioxidative properties.
Isolation and Purification of Galloyl, Caffeoyl, and Hexahydroxydiphenoyl Esters of Glucoses from Balanophora simaoensis by High-Speed Countercurrent Chromatography and Their Antioxidant Activities In Vitro
Authors: Fang Lei , He Tian-Tian , Wang Xiao , Zhou Jie
Published: August 2018

High-speed counter-current chromatography was used to separate and purify galloyl, caffeoyl, and hexahydroxydiphenoyl esters of glucoses from the aerial parts of the parasitic plant Balanophora simaoensis for the first time using n-hexane-ethyl acetate-methanol-water (1:2:1:2, v/v) as the optimum solvent system. Accordingly, 1-O-(E)-caffeoyl-3-O-galloyl-β-d-glucopyranose (I, 12.5 mg), 1-O-(E)-caffeoyl-3-O-galloyl-4,6-(S)-hexahydroxydiphenoyl-β-d-glucopyranose (II, 27.2 mg), and 1-O-(E)-caffeoyl-4,6-(S)-hexahydroxydiphenoyl-β-d-glucopyranose (III, 52.8 mg) with 98.0%, 98.5%, and 98.7% purities, respectively, were purified from 210 mg crude extract of B. simaoensis in a one-step separation. The structures of the glucose esters were identified by electrospray ionization mass spectrometry (ESI-MS) and nuclear magnetic resonance spectra (NMR). Their antioxidant activities were evaluated by measuring their inhibition activity on liver microsomal lipid peroxidation induced by the Fe2+-Cys system in vitro. Compounds I–III showed significant antioxidant activities with IC50 values ranging from 2.51 to 6.68 μm, respectively.
CF3-Substituted Mollugin 2-(4-Morpholinyl)-ethyl ester as a Potential Anti-inflammatory Agent with Improved Aqueous Solubility and Metabolic Stability
Authors: Hong Ki Bum , Kim Darong , Kim Bo-Kyung , Woo Seo Yeon , Lee Ji Hoon , Han Seung-Hee , Bae Gyu-Un , Kang Soosung
Published: August 2018

Although mollugin, the main ingredient of the oriental medicinal herb Rubia cordifolia, has considerable anti-inflammatory effects, it has poor aqueous solubility as well as poor metabolic and plasma stability. To overcome these shortfalls, various mollugin derivatives have been synthesized and evaluated for their ability to inhibit U937 monocyte cell adhesion to HT-29 colonic epithelial cells in TNF-α- or IL-6-induced models of colon inflammation. The 2-(4-morpholinyl)-ethyl ester of CF3-substituted mollugin (compound 15c) showed good water solubility, improved metabolic and plasma stability, and greater inhibitory activity than mesalazine in both the TNF-α- and IL-6-induced colonic epithelial cell adhesion assays, suggesting that 15c is a potential anti-inflammatory agent.
Astragaloside IV Attenuates Acetaminophen-Induced Liver Injuries in Mice by Activating the Nrf2 Signaling Pathway
Authors: Li Lei , Huang Wenxiang , Wang Shoukai , Sun Kecheng , Zhang Wenxue , Ding Yanmei , Zhang Le , Tumen Bayaer , Ji Lili , Liu Chang
Published: August 2018

Acetaminophen (APAP) is a well-known antipyretic and analgesic drug. However, the accidental or intentional APAP overdose will induce liver injury and even acute liver failure. Astragaloside IV (AS-IV), a bioactive compound isolated from Astragali Radix, has been reported to have protective effects on the digestive and immune systems because of its anti-oxidant and anti-inflammatory properties. This study aims to observe whether AS-IV pretreatment provides protection against APAP-induced liver failure. The results of serum alanine/aspartate aminotransferases (ALT/AST) analysis, hepatic glutathione (GSH), and malondialdehyde (MDA) amounts, and liver superoxide dismutase (SOD) activity showed that AS-IV protected against APAP-induced hepatotoxicity. Liver histological observation further evidenced this protection provided by AS-IV. AS-IV was found to reverse the APAP-induced increased amounts of pro-inflammatory cytokines, including interleukin 1β (IL-1β), interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α). Western-blot analysis showed that AS-IV increased the transcriptional activation of nuclear factor erythroid 2-related factor 2 (Nrf2), and enhanced the expression of heme oxygenase 1 (HO-1) and reduced nicotinamide adenine dinucleotide phosphate (NAD(P)H): quinone oxidoreductase 1 (NQO1) in the presence of APAP. AS-IV also decreased the expression of kelch-like ECH-associated protein-1 (Keap1). In conclusion, we demonstrated that AS-IV exerted a strong protection against APAP-induced hepatotoxicity by activating Nrf2 antioxidant signaling pathways.
Protomer-Dependent Electronic Spectroscopy and Photochemistry of the Model Flavin Chromophore Alloxazine
Authors: Matthews Edward , Cercola Rosaria , Dessent Caroline E. H.
Published: August 2018

Flavin chromophores play key roles in a wide range of photoactive proteins, but key questions exist in relation to their fundamental spectroscopic and photochemical properties. In this work, we report the first gas-phase spectroscopy study of protonated alloxazine (AL∙H+), a model flavin chromophore. Laser photodissociation is employed across a wide range (2.34–5.64 eV) to obtain the electronic spectrum and characterize the photofragmentation pathways. By comparison to TDDFT quantum chemical calculations, the spectrum is assigned to two AL∙H+ protomers; an N5 (dominant) and O4 (minor) form. The protomers have distinctly different spectral profiles in the region above 4.8 eV due to the presence of a strong electronic transition for the O4 protomer corresponding to an electron-density shift from the benzene to uracil moiety. AL∙H+ photoexcitation leads to fragmentation via loss of HCN and HNCO (along with small molecules such as CO2 and H2O), but the photofragmentation patterns differ dramatically from those observed upon collision excitation of the ground electronic state. This reveals that fragmentation is occurring during the excited state lifetime. Finally, our results show that the N5 protomer is associated primarily with HNCO loss while the O4 protomer is associated with HCN loss, indicating that the ring-opening dynamics are dependent on the location of protonation in the ground-state molecule.
Toward Accurate Quantitative Elasticity Mapping of Rigid Nanomaterials by Atomic Force Microscopy: Effect of Acquisition Frequency, Loading Force, and Tip Geometry
Authors: Zeng Guanghong , Dirscherl Kai , Garnæs Jørgen
Published: August 2018

Atomic force microscopy (AFM) has emerged as a popular tool for the mechanical mapping of soft nanomaterials due to its high spatial and force resolution. Its applications in rigid nanomaterials, however, have been underexplored. In this work, we studied elasticity mapping of common rigid materials by AFM, with a focus on factors that affect the accuracy of elasticity measurements. We demonstrated the advantages in speed and noise level by using high frequency mechanical mapping compared to the classical force volume mapping. We studied loading force dependency, and observed a consistent pattern on all materials, where measured elasticity increased with loading force before stabilizing. Tip radius was found to have a major impact on the accuracy of measured elasticity. The blunt tip with 200 nm radius measured elasticity with deviation from nominal values up to 13% in different materials, in contrast to 122% by the sharp tip with 40 nm radius. Plastic deformation is believed to be the major reason for this difference. Sharp tips, however, still hold advantages in resolution and imaging capability for nanomaterials.