bluuebunny/crossref_metadata_2025 huggingface dataset:
A Study to Assess the Knowledge Regarding Effect of Classroom Noise on Teaching and Learning Among B.Sc. Nursing 3rd Semester Students Studying in SCPM College of Nursing & Paramedical Science, Gonda with the View to Develop Informational Booklet
Authors: M Sr. Prof. Vijayasanthi , Mishra Pallvi , Verma Nisha
Published: April 2024

Noise, a disruptive sound affecting well-being, is a concern in schools, impacting education by causing attention and memory issues in students. This study was conducted to assess the knowledge regarding effect of classroom noise on teaching and learning among b.sc. Nursing 3rd semester students studying in SCPM college of nursing & paramedical science, Gonda with the view to develop informational booklet. The major objective of the study is to determine the knowledge level of third-semester B.Sc. Nursing students regarding the impact of classroom noise on teaching and learning and to explore the connection between the students' knowledge of classroom noise effects on teaching and learning and their demographic characteristics. This study utilized a descriptive research approach and design. Non-probability purposive sampling was used to select a sample of 60 third-semester B.Sc. Nursing students at SCPM College of Nursing & Paramedical Sciences in Gonda. Data was collected through questionnaires covering demographic information and knowledge about the impact of classroom noise on teaching and learning. Data analysis involved descriptive and inferential statistics, including frequency, percentage, and Chi-square tests. The findings indicate that 60% of the students had inadequate knowledge, 37% had moderate knowledge, and only 4% had adequate knowledge regarding the effects of classroom noise on teaching and learning.

Key words: Noise; students; knowledge
Pelatihan Exspressive Art untuk Menurunkan Emosi Negatif pada Anak Yatim & Dhuafa Mizan Amanah Yogyakarta
Authors: Azis Agung Putra , Dyasti Maharani Eucalypta Shafira , Amalis Fitri , Hidayah Nurul
Published: April 2024

Program pelatihan seni ekspresif menjadi solusi efektif untuk mengatasi emosi negatif pada anak-anak di Asrama Yatim & Dhuafa Mizan Amanah Yogyakarta. Dengan fokus pada kelompok usia 6-12 tahun, metode kuantitatif digunakan untuk mengukur dampak program ini. Skala diberikan kepada 14 anak, dan hasilnya dievaluasi menggunakan uji Wilcoxon signed rank. Hasil penelitian menunjukkan perbedaan yang signifikan antara tingkat emosi negatif sebelum (pretest) dan setelah (posttest) anak-anak mengikuti pelatihan seni ekspresif. Pelatihan ini berhasil memberikan outlet bagi mereka untuk mengekspresikan emosi negatif melalui karya seni, yang pada gilirannya menurunkan tingkat emosi negatif secara keseluruhan. Pelatihan seni ekspresif tidak hanya terbukti efektif, tetapi juga sangat membantu anak-anak yang mengalami kehilangan keluarga. Dengan menurunkan tingkat emosi negatif, program ini memberikan dampak positif pada kesejahteraan anak-anak, membantu mereka dalam mengatasi tantangan emosional sehari-hari. Dengan demikian, pelatihan seni ekspresif muncul sebagai pendekatan yang berdaya guna dan bermanfaat untuk menangani masalah emosi negatif pada anak-anak di lingkungan asrama ini.
Pengelolaan Nyeri pada Pasien Diabetes Mellitus Menggunaka Terapi Sujok: A Case Report
Authors: Rukhama Rafi Achmad , Triatmojo Setyo , Nurjannah Intansari
Published: April 2024

Pada penderita DM sering terjadi nyeri kaki yang oleh suatu kondisi yang disebut neuropati perifer, yang terjadi ketika kadar gula darah tinggi yang menyebabkan kerusakan pada saraf di tungkai dan kaki. Terapi Sujok dilakukan pada kelompok lansia di Puskesmas Jetis II Bantul dan Masjid Baiturrohman Popongan Sleman oleh mahasiswa Ilmu Keperawatan FK-KMK UGM yang dilatih menjadi terapis Sujok. Keluhan pasien, karakteristik nyeri, dan terapi dilaporkan dalam artikel ini. Lima pasien DM mengalami berbagai keluhan nyeri. Terapi Sujok menggunakan basic correspondence system dengan pemijatan, biji fenugreek, dan terapi warna berhasil mengurangi skala nyeri pasien. Hasil terapi menunjukkan bahwa terapi Sujok dapat efektif mengurangi nyeri kaki pada pasien DM. Kombinasi terapi biji dan warna memberikan pendekatan holistik yang inovatif. Hasil ini menunjukkan potensi terapi Sujok sebagai alternatif komplementer dalam manajemen nyeri pada pasien DM.
Edukasi Pencegahan dan Pengendalian Penyakit Degeneratif sebagai Upaya Peningkatan Pengetahuan dan Perubahan Perilaku Masyarakat
Authors: Faradiba Faradiba , Heriatmo Nadia Larasinta , Pratita Rasta Naya , Sari Intan Permata
Published: April 2024

Penyakit hipertensi dan diabetes merupakan penyakit menurun dengan tingkat morbiditas dan mortalitas yang tinggi. Penderita hipertensi di Indonesia mencapai 34,11% dan diabetes mencapai 8,5% pada 2018 mengindikasikan pengetahuan masyarakat tentang pencegahan penyakit degeneratif cukup rendah sehingga perlu intervensi edukasi. Pengetahuan menjadi faktor kunci peningkatan kesadaran dan menjadi input utama perubahan perilaku. Tujuan penelitian ini adalah meningkatkan pengetahuan masyarakat Kecamatan Cinangka melalui intervensi edukasi pencegahan hipertensi dan diabetes. Metode yang digunakan adalah metode deskriptif dengan pendidikan kesehatan/penyuluhan dan metode kuantitatif untuk mengevaluasi hasil penyuluhan menggunakan kuesioner. Berdasarkan hasil, persentase peningkatan pengetahuan masyarakat paling tinggi pada Q2 sebesar 28% tentang penyebab hipertensi, 24% pada Q8 dan Q9 tentang komplikasi diabetes dan upaya menjaga kadar gula darah, serta seluruh responden menjawab dengan benar pertanyaan tentang pencegahan hipertensi setelah penyuluhan dilakukan. Secara keseluruhan, terjadi peningkatan pengetahuan pada masyarakat dengan rata-rata responden dengan jawaban benar pada pretest 71,20% menjadi 90,40% pada posttest. Dapat disimpulkan bahwa kegiatan pendidikan kesehatan yang dilakukan berjalan efektif untuk meningkatkan pengetahuan masyarakat Kecamatan Cinangka.
EPIDEMIOLOGICAL SITUATION OF SKIN CANCER AND MELANOMIA IN THE REPUBLIC OF KAZAKHSTAN IN 2012-2022
Authors: Tuleuova D. , Serikbayev G. , Kurmanalyev А. , Pyssanova Z. , Yelekbayev А.
Published: April 2024

Relevance: Skin cancer, including melanoma, is a major health problem and one of the most common cancers in the world.

The study aimed to obtain a complete epidemiological picture of skin cancer and melanoma in the Republic of Kazakhstan for 11 years, including analysis of data for 2022, considering various parameters such as age, sex, ethnicity, region, and tumor type.

Methods: The study used data from patients registered in the national cancer registry of the Republic of Kazakhstan from 2012 to 2022, diagnosed with skin carcinoma and skin melanoma (ICD-10 code: C44-C43). The number of skin carcinomas and melanoma cases is presented as absolute and crude rates per 100,000 population. Absolute standardized morbidity and mortality rates were calculated using the world standard (World).

Results: At the end of 2022, 19,714 and 2,689 patients were diagnosed with “Skin Cancer” or “Skin Melanoma” in the Republic of Kazakhstan, respectively. From 2012 to 2022, the incidence of skin cancer increased by 24% and melanoma by 15%. In 2022, the incidence of skin cancer and melanoma was higher among women by 24% and 26%, respectively. Mortality from skin cancer is in 23rd place, from melanoma in 21st place. Mortality rates from skin cancer and melanoma were 0.5 and 0.7 per 100 thousand population, respectively. The peak incidence of skin cancer in 2022 was observed in the age group 65-74 years (36%), and mortality in the age groups 65-74 and 75-84 years (17% each). The peak incidence of skin melanoma in 2022 was observed in the age groups 55-64 years and 65-74 years (24% and 25%), and mortality in the groups 45-54 years and 35-44 years (14% and 10%).

Conclusion: There has been a steady increase in the incidence of skin cancer and melanoma, which indicates the seriousness of this problem in the country and underlines the need for further measures to prevent, diagnose and treat skin cancer and melanoma in the Republic of Kazakhstan. It should be remembered that many cases of skin cancer can be prevented with simple precautions.
DNA BREAKS AND REPAIR IN LYMPHOCYTES AS A DIAGNOSTIC MARKER IN PATIENTS WITH GASTRIC CANCER
Authors: Tulyayeva A. , Iztleuov E. , Koishybaev A. , Aitmagambet P. , Imanbayev N. , Zhurabekova G. , Batyrova G. , Zholmukhamedova D. , Kereeva N. , Aitmagambetova M.
Published: April 2024

Relevance: Colorectal cancer (CRC), arising from the right-sided or left-sided colon, is a separate clinical and pathological unit. The status of KRAS and its predictive value in CRC remain controversial.

The study aimed to explore the effect of primary tumor localization on KRAS gene status in CRC.

Methods: The study included 60 patients with colon and rectal cancer. The KRAS mutation test was performed on paraffin-coated tumor samples using PCR methods. Colon cancer was divided into right-sided colon cancer (RSCC) and left-sided colon cancer (LSCC).

Results: KRAS mutation was found much more often in rectal cancer (RC) and sigmoid colon (SC) (p=0.413) than in tumors in other parts of the colon. A combined analysis of our data and previously published data showed that KRAS mutation was more common in PSTC, especially in the area of the hepatic bend of the colon than in LSTC (p=0.120). The association of the KRAS mutation with the patient’s age (p<0.012) and the duration of hospitalization (p<0.001) was established.>

Conclusion: Our study revealed no significant difference in the KRAS status between colon cancer and rectal cancer. However, KRAS mutation was much more common in RSCC compared to LSCC. Patients with RSCC with mutated KRAS also had a worse prognosis and required longer hospitalization compared to wild-type KRAS. However, patients with LSCC did not demonstrate a similar effect.
TREATMENT OF INTRAPARENCHYMAL CHORDOID MENINGIOMA: A CLINICAL CASE
Authors: Ryskeldiyev N. , Zhetpisbaev B. , Zhaxybayev D. , Berdibayeva D. , Dubchev D. , Pochivalov D. , Kurmanakhunov A.
Published: April 2024

Relevance: Meningioma has many forms, each with a specific histological structure and treatment tactics. Meningiomas are the most common intracranial neoplasms, most of which have an extracerebral location, and their intraparenchymal location is rare.

The study aimed to describe a case of treatment of intraparenchymal chordoid meningioma.

Methods: The article describes a case of treatment of intraparenchymal chordoid meningioma, which is rare in localization, structure, and possible combination with other systemic diseases.

Results: Patient B. was admitted to the clinic for surgical treatment for an intracranial neoplasm; the main complaints were the presence of seizures and their transition to epileptic status. The tumor was removed completely, after which it was sent for further histological and immunohistochemical examination. The examination of micro slides revealed the presence of chordoid meningioma in the patient. In the postoperative period, as well as at control examination after 3 months, the patient showed a decrease in the number of seizures and no transition to epileptic status. MRI control showed no relapse of tumor growth.

Conclusion: WHO classifies chordoid meningioma as a rare grade II meningioma. Chordoid meningioma often requires further radiation therapy, especially with partial or subtotal removal, due to a slightly higher risk of relapse compared to grade I meningiomas. This disease can occur independently or in association with Castleman syndrome and can be asymptomatic for a long time; this requires further follow-up of the patient.
GENETIC MECHANISMS OF HEPATOCELLULAR CARCINOMA: LITERATURE REVIEW
Authors: Amirkulova A. , Derbissalina G. , Shanazarov N. , Bekbergenova Zh.
Published: April 2024

Relevance: Hepatocellular carcinoma (HCC) is the most common form of primary liver malignancy. This form of liver cancer is characterized by rapid progression and poor survival prognosis. Understanding the genetic mechanisms that underlie HCC is of great importance for developing new diagnostic and therapeutic approaches.

The study aimed to the genetic factors in the development of hepatocellular carcinoma.

Methods: This review used various sources of literature, including scientific articles and reviews. We reviewed the results of scientific and clinical studies published in 2018-2023 and indexed in the PubMed, Cochrane library, Scopus and Web of Science databases, using the keywords “hepatocellular carcinoma,” “genes,” and “genetic predictors.” Inclusion of articles in the review was based on their content and relevance to the research topic.

Results: Various genes associated with hepatocellular carcinoma were analyzed, including genes frequently mutated in HCC, as well as genes that play a role in the regulation of cell growth, apoptosis, metastasis, and invasion. Epigenetic changes such as DNA methylation and chromatin modifications have been investigated. The roles of microRNAs, long non-coding RNAs, circulating microparticles and other biomarkers in the diagnosis and prognosis of HCC were also reviewed.

Conclusion: The materials and methods used in this review allowed us to cover a wide range of genes and molecular mechanisms associated with hepatocellular carcinoma. Understanding these mechanisms plays an important role in the development of new diagnostic and therapeutic approaches to combat this dangerous form of liver cancer. Further research in this area will help expand our knowledge base and improve the HCC treatment.
MODERN IMAGING TECHNIQUES IN THE ASSESSMENT OF MALIGNANCY IN GLIAL BRAIN TUMORS: LITERATURE REVIEW
Authors: Toleshbaev D. , Ainakulova A. , Zhakenova Zh. , Akimtay K. , Myrzabaeva G. , Ramazan A. , Zholdybay Zh.
Published: April 2024

Relevance: Gliomas represent a major group of primary central nervous system tumors, accounting for approximately 80% of all malignant brain neoplasms. Recent advances in molecular diagnostics, including the identification of mutations in the isocitrate dehydrogenase (IDH) gene, offer new opportunities to improve the classification of gliomas and to understand the mechanisms of their development. IDH mutations, which are found in a large proportion of gliomas, are associated with a better prognosis and represent an important biomarker for the development of targeted therapeutic strategies. Diagnostic techniques, particularly magnetic resonance imaging (MRI), also play an important role, providing additional ways to assess the morphological and biological characteristics of gliomas, contributing to a more accurate determination of tumor malignancy and molecular profile, which is key to treatment decisions.

The study aimed to To study the possibilities of magnetic resonance imaging in assessing the degree of malignancy of glial brain tumors.

Methods: A literature review was performed using the keywords: glioma, IDH mutation, IDH wild-type, MRI, magnetic resonance spectroscopy (MRS), apparent diffusion coefficient (ADC), diffusion-weighted imaging (DWI), diffusion tensor imaging (DTI), diffusion kurtosis image (DKI), Susceptibility Weighted Imaging (SWI) in PubMed, BMC Medicine, and Google Scholar databases. The review includes the results of an analysis of 45 literature reviews on the diagnostic capabilities of molecular diagnostics and MRI to assess the malignancy of gliomas.

Results: This review highlights the importance of current approaches to the diagnosis of gliomas, demonstrating that different grades of malignancy and IDH mutation status are associated with unique features on MR imaging, including differences in localization, signal, and enhancement patterns. DTI and DWI extend the ability of MRI to assess tissue microstructure, allowing for more precise tumor characterization. Studies combining MRI morphologic features, ADC and DTI parameters offer a non-invasive approach to glioma prognosis, highlighting the importance of integrated use of imaging modalities to improve diagnosis and therapy.

Conclusion: The use of magnetic resonance imaging allows for more accurate morphologic and metabolic characterization of gliomas in assessing the degree of malignancy, allowing physicians to make more accurate prognostic assessments and select the most appropriate treatment strategy.
The Sixtieth Anniversary of the Institute of Applied Physics of Moldova State University. Traditions and Modernity
Authors: Bologa Mircea
Published: April 2024

The sixty–year history of the Institute of Applied Physics of Moldova State University is outlined starting from the formation of the first basic laboratories, pilot production, and launching the journal "Elektronnaya obrabotka materialov” to a reputable scientific center recognized in the world scientific and technical community with a well-known scientific and technical potential, with organization of conferences and scientific forums, extensive international relations, training of highly qualified personnel, involvement in national and international projects. Scientific directions, the structure, recognized fundamental and applied results, well-known scientific schools, publication of a high-rating international journal, of monographs, articles in prestigious journals, international scientific cooperation, numerous organized conferences, formulation and development of works providing a closed cycle – from fundamental to applied research, are outlined. The implementation of the results in the form of advanced technologies and technical means for their application, the main aspects of optimizing the structure, updating the research topics, the development of innovative, patented and publishing activities are described. Numerous illustrations reflect events of the past years – components of the "biography" of the institute, complement the description, create a more comprehensive retrospective picture of the path traveled, including worthy of attention facts on participation in events that determine the future of research and innovation. It is emphasized that the Institute of Applied Physics with its interesting and significant, relevant and promising fundamental and applied research, impressive achievements, well-founded traditions, aspirations and expectations, has been and will remain bright and attractive also for those wishing to continue their trainings through doctoral and postdoctoral programmes and work at the institute or collaborate with its friendly staff.
Assessing the Utilization and Effectiveness of Content Marketing in Business Practices in Botswana
Authors: Fulu Obonetse
Published: April 2024

The study ascertains the extent to which content marketing is used by businesses. The objective of the study was to ascertain the extent to which content marketing is used by businesses. The study employed the quantitative research method where the data for the study were collected through the survey approach. The regression method was employed to analyse the data collected and it was found that: access to micro content does not significantly influence individual trust for a product compared to access to large content. However, access to content, online presence, age, and gender significantly influence consumer trust. Content marketing, higher online purchasing behavior, and higher consumer age significantly increase trust for a product. Males were less likely to have reduced trust compared to females. The research suggests that modern consumers are more concerned with the quality and dependability of information than its length. Therefore, businesses should focus on providing accurate, transparent, and dependable information. Content marketing plays a crucial role in fostering consumer confidence, as it increases trust by providing thorough and trustworthy information. This highlights the importance of digital marketing methods and the need for businesses to invest in informative, precise, and interesting content marketing efforts to increase brand trust and customer loyalty.
The moderating role of perceived environmental uncertainty in the impact of corporate governance on strategy implementation: An agency theory perspective
Authors: Shatem Maryam , Abou-Moghli Azzam
Published: April 2024

The study delves into how governance, environmental unpredictability and strategic management intersect, with agency theory offering a framework to comprehend this connection. It is evident how the structure of governance can influence the actions of managers and the results of organizations, amidst evolving conditions. Descriptive analytical approaches were used, and utilized an electronic questionnaire, as the main tool for gathering data. It involved 254 individuals randomly selected from Information and Communication Technology companies in Amman, Jordan including both managers and non-managers. Various statistical techniques, such as inferential methods using SPSS version 26 for Windows were employed to explore research questions and test hypotheses. The study discovered that the perceived uncertainty in the environment plays a role in influencing how corporate governance affects strategy implementation, in information technology firms. The findings suggest. Studying the environment to better grasp and respond to uncertainties. Additionally, it is advised to tailor governance practices and strategies to manage risks and obstacles resulting from shifts.
Systematic and unsystematic determinants of liquidity risk in the Islamic banks in the middle east
Authors: Badarin Abdalla Mohammad khalaf Al , Al-Jarrah Mefleh Faisal Mefleh , Rababah Adnan Mohamad Yosef , ALotoom Amer Yosef Mohammad
Published: April 2024

Liquidity risk (LR) is a concern in Islamic banks and may lead to major problems if not managed appropriately and planned, due to the lack of external liquidity sources for Islamic banks. However, the purpose of this article is to look at the factors that affect liquidity risk in Middle Eastern Islamic banks. To arrive at a substantial and compelling conclusion, the cross-sectional data from 30 Islamic banks was gathered between 2011 and 2022. The random effect regression model, GMM, and fixed effect regression model were all utilized. According to the report, Islamic banks in the Middle East have safe levels of liquidity. It also demonstrates how the financing-to-deposit ratio, inflation, economic growth, and return on assets all have a favorable impact on Islamic banks' liquidity risks. Furthermore, the study discovered that non-performing financing, capital sufficiency, operational effectiveness, and scale had no bearing on the liquidity issues associated with Islamic banks. This paper provided guidance regarding liquidity risk management procedures and systems in Islamic banks in order to design banking liquidity risk management policies. To avoid liquidity risks in Islamic banks, the optimal level of financing to deposit ratio must be determined, maintaining the quality of financing, reducing the non-performing loan ratio to the lowest possible level, and enabling Islamic banks to benefit from the central bank as a last resort for liquidity.
Method Development and Validation for the Estimation of Umifenovir in Bulk and Tablet Formulation by UV-Spectrophotometric and RP-HPLC
Authors: Somkuwar Komal , Sabale Prafulla , Sawale Vaibhav , Rahangdale Priya
Published: April 2024

Umifenovir, an antiviral drug that is used to treat influenza, has recently been used in COVID-19 infection. According to a literature survey, no UV technique for the estimation of umifenovir has yet been established; hence, there is an imperative need for a simple analytical method. Additionally, we developed an alternative, RP-HPLC method for the estimation of umifenovir. UV spectrophotometry was carried out at 223nm absorption maxima using the solvent methanol. A concentration range of 2-12µg/ml was found to obey Beer's Law, with a correlation coefficient (r2) of 0.9995. A C-18 column (250mm 4.6µm, 5µm) was used for chromatographic separation using isocratic mode. The mixture consisted of acetonitrile: 0.1% trimethylamine (pH adjusted to 2.7 by the addition of orthophosphoric acid) 60:40 as the mobile phase with a flow rate of 1.0 ml/min. The temperature was kept at 25ºC, and detection at 223nm was performed using a PDA detector. The estimated percentage of the drug was close to 100%, corresponding to the label claim of the tablet made in the laboratory. The results and statistical study demonstrated the utility of the current methods in the routine evaluation of umifenovir bulk and formulation.
Fluctuations due to Altitude, Season and Time on Potency of Stigmasterol content of Jamun
Authors: Gautam Palshikar , Soni Gauravkumar , Otari Kishor , Pitchaimuthu Shanmugapandiyan
Published: April 2024

Now a day, more number of individuals from all over the world get suffered from diabetes which is an endocrine and metabolic disorder. Herbal medicines are used for treatment of such a chronic diseases from hundreds of years and are continuously rising in todays era due to less adverse effects, treats root cause and low cost. Jamun acts as a promising herb due to its proven hypoglycemic action and ability to prevent many adverse conditions due to it. Stigmasterol, an active phytoconstituent from Jamun has been credited for its antidiabetic potential. Seasonal fluctuations have impact on availability of active components in herbs which also influence its therapeutic efficacy. For getting yield with more potency, the harvesting should be done properly at accurate altitude, month and duration. Research objective is to find out changes in contents of medicinal plant Jamun leaves for antidiabetic potential. Plant sample used in different seasons, time and places, identification and analysis was performed. Macroscopy, microscopy, proximate phytochemistry, extraction yield and estimation of the yield of stigmasterol. Morphological, microscopical and extractive values appears fluctuations Maximum levels of ethanol extract with higher concentration of stigmasterol were obtained in August month.
Isolation of yidRhv Gene from Hypervirulent Klebsiella pneumoniae Indonesia Strain and in silico study of Gene product
Authors: Permadi Ichsanto , Helianti Is , Prawiro Soemarno Reto , Raras Tri Yudani Mardining
Published: April 2024

There is an increase rate of hypervirulent Klebsiella pneumoniae (hvKP) that urges the need for preventive and effective immunotherapies, such as vaccine. The YidR gene is a new gene for adherence to host that is conserved in many strain of Klebsiella sp, offering its potency as vaccine candidate. This study aims to isolate the YidRhv gene and analyze the YidRhv protein in silico for future work as vaccine candidate against hypervirulent K. pneumoniae Indonesia strain. Klebsiella pneunomiae is tested for hypervirulency using LAMP-PCR method. The YidRhv gene was amplified via PCR method and the fragment produced was cloned and sequenced. The protein structure and epitope prediction for T-cell and B-cell of YidRhv protein was analyzed using bioinformatics approach. DNA sequence of YidRhv gene strain consisted of 1227 base pairs and showed 99,75 % homology to yidR from classical K pneumoniae. However, several single nucleotide polymorphism were found in this gene. The protein structure demonstrated that the YidRhv is possibly outer membrane protein. The protein YidRhv contain predicted epitopes that showed high affinity to B-cell but low affinity to T-cell.
INVASIVE CERVICAL RESORPTION OF UNCOMMON ORIGIN: A CASE REPORT WITH 14-YEAR FOLLOW-UP
Authors:   Department of Conservative Dentistry, Faculty of Dental Medicine, Medical University, Sofia, Bulgaria., Kouzmanova Yaneta
Published: April 2024

Background: Invasive cervical resorption (ICR) is a complex, relatively uncommon, and insidious phenomenon. Its occurrence is associated mainly with local predisposing factors, but systemic risk factors may be involved as well. An ICR lesion that develops in the absence of an identifiable cause is termed 'idiopathic'. Case report: This study presents the surgical management and very long-term follow-up results of an "idiopathic" Class 3 ICR lesion in the maxillary central incisor. The case provides a unique insight into an uncommon ICR lesion that exhibited an unusual appearance and features. For the repair material, a sandwich technique was applied using mineral trioxide aggregate (MTA) covered with glass ionomer cement (GIC). At the 14-year follow-up, the tooth was symptom-free and functional; however, the disadvantages of both materials were clearly demonstrated. From that perspective, the study highlighted the discoloration potential of the white form of MTA-Angelus and the lack of regenerative properties of the GIC used. Remarkably, 12 years after the surgery, the patient was diagnosed with Familial Mediterranean fever, a rare systemic disease. However, the connection between this genetic disease and the initiation of ICR remains an open question for now. Conclusion: The clinician should be alert for the occurrence of ICR lesions, especially in patients with concomitant systemic disorders. The right choice of appropriate repair material is a key factor for the healing outcome of ICR lesions in the anterior zone.
Simulating Liver Resections to Predict Hepatic Perfusion Alterations
Authors: Rao Joseph Sushil , Tithof Jeff
Published: April 2024

Partial liver resections are routinely performed in living donor liver transplantation and to debulk tumours in liver malignancies, but surgical decisions on vessel reconstruction for adequate inflow and outflow are challenging. Pre-operative evaluation is often limited to radiological imaging, which fails to account for post-resection haemodynamic alterations. Substantial evidence suggests post-surgical increase in local volume flow rate enhances shear stress, signalling hepatic regeneration, but excessive shear stress has been postulated to result in small for size syndrome and liver failure. Predicting haemodynamic alterations throughout the liver is particularly challenging due to the dendritic architecture of the vasculature, spanning several orders of magnitude in diameter. Therefore, we developed a mathematical lumped parameter model with realistic heterogeneities capturing inflow/outflow of the human liver to simulate acute perfusion alterations following surgical resection. Our model is parametrized using clinical measurements, relies on a single free parameter and accurately captures established perfusion characteristics. We quantify acute changes in volume flow rate, flow speed and wall shear stress following variable, realistic liver resections and make comparisons with the intact liver. Our numerical model runs in minutes and can be adapted to patient-specific anatomy, providing a novel computational tool aimed at assisting pre- and intra-operative surgical decisions for liver resections.
The Discourse of Silence as a Testimony of Resistance: A Study with Reference to Select Poems by Imtiaz Dharker
Authors: Sneha Singh
Published: April 2024

The present paper aims to inquire the synthesis of resistance in Imtiaz Dharker’s poetry and how she invokes the concept by using silence as a core element to convey it. Through the select poems, the question of whether resistance in her poems is recognized and intentional shall be addressed. It also intends to move beyond the definitional spectrum of resistance and analytically find the lines of dissent which Dharker incorporates. This endeavor shall resolve the conceptual parameter of resistance and how silence can also be a crucial part of it. There shall also be an attempt to find how silence is entrapped and plays an important role in the formulation of active protest against oppressive regimes. The poems represent both intentional and unintentional silence, and through the lens of resistance, the paper facilitates a critical introspection of the same to find if it originates from long term acculturation of methodologies of rebellion or simply embodies an innovative inquiry.
The Exhilaration of Translation: The Epitome of Literary Culture
Authors: Wasim Azam
Published: April 2024

Translation can be an emulation of written statements extracted from the original thoughts and notions that could be acknowledged throughout the whole literature of earthly culture. As far as Indian translated literature is concerned, there is a road of accomplishing the task of literary culture on a larger scale such as translation of several texts. Some regional translations into English are stipulated across the whole India such as stories of Munshi Premchand titled Panch Parmeshwar for The Divine Arbiter, Kafan for The Shroud and so forth. The works of Munshi Premchand are translated into English and Russian after his demise. At the world level, we can get an example of Kahlil Gibran and Rumi whose works are translated from Arabic and Persian respectively into English and other European languages. The main resolution is to ensure that each and every member of society can perceive the fragrance of the culture with the translation from one language to the source language. This paper holds descriptive, qualitative and experimental findings to ratify translation as a big concept of literary culture. The objective of this paper invokes translators to translate the texts or any reading platforms as much as possible to convey parameter of culture to the readers, audiences and common authorities by which they come to know the realization of situations either catastrophic or placid. Translation is basically a new trend of the concept of culture.
La pagina gialla
Authors: Ventura Alessandro
Published: April 2024

Vaccino anti-HPV: prevenzione assoluta del cancro della cervice? L'impronta del dolore Appetiti pericolosi Quando le vittime (e i carnefici) sono i più sfortunati. Virus Respiratorio Sinciziale (VRS): ancora lui
Infezione da West Nile Virus
Authors: Orsi Francesca , Bini Giulia , Baroncelli Giampiero I , Bonuccelli Alice , Peroni Diego
Published: April 2024

West Nile Virus infection in children may usually occur as a self-limiting febrile illness or rarely as a neuroinvasive disease with possible late neurological sequelae. Therefore, the paediatrician should take into consideration this condition in febrile children who also showed neurological signs or symptoms. Early recognition of the disease and appropriate management may result in a favorable prognosis.
La sindrome di Stickler
Authors: Cazzaniga Laura , Abramo Michele , Selicorni Angelo
Published: April 2024

“Occhio” alle sequenze di Pierre-Robin, soprattutto se “dure d’orecchio”
La malattia come teatro della vita
Authors: Stracquadaino Rita
Published: April 2024

Tre toccanti storie che mettono in luce gli aspetti umani e partecipi dell’assistenza sanitaria. Una proposta editoriale di Medico e Bambino di raccogliere storie come queste per esplorare il lato umano e narrativo della nostra professione e condividere emozioni e riflessioni.
Bewegung im Raum der Gründe
Authors: Streng Dierk
Published: April 2024

In diesem Buch wird unser Handeln als Bewegung in einem Feld von Gründen gedacht, das aus den Objekten und Personen hervorgeht, die uns erscheinen. Durch die neuartige Betrachtungsweise wird deutlich, wie wir uns in unseren Emotionen zentral an der Vertrauenswürdigkeit von Akteuren orientieren, uns zu diesen positionieren und sie auch sanktionieren. Und es zeigt sich, welche Folgen dies dafür hat, was jeweils zu tun vernünftig ist. Die hier entwickelte Philosophie der Praxis knüpft an elementare Intuitionen an und bietet Orientierung im Privaten wie im Politischen Diese Publikation erscheint unter der Creative-Commons-Lizenz CC BY-ND 3.0 DE als Book-on-Demand sowie digital als Open-Access-Titel.
Quality of Life in Ugandan Children and Young Adults After Surgery for Congenital Heart Disease: Mixed Methods Approach
Authors: Searchinger Chloe , Nalubwama Hadija , Pulle Jafesi , Mehta Rittal , Tumwbaze Hilda , Kyarimpa Rachel , Mwima Rachel , Atukunda Emily , Bua Bobson , Sarnacki Rachel , Sherman Meredith G. , Oketcho Michael , Zimmerman Meghan , Nakitto Miriam , Longenecker Chris T. , Webel Allison , Scheel Amy , Lwabi Peter S. , Sable Craig A.
Published: April 2024

Background: Health-related quality of life (HRQOL) is a critical issue for patients undergoing surgery for congenital heart disease (CHD) but has never been assessed in a low-income country. We conducted a cross-sectional mixed methods study with age-matched healthy siblings serving as controls at the Uganda Heart Institute.
Methods: One-hundred fifteen CHD pediatric and young adult patients and sibling control participants were recruited. Health-related quality of life was assessed using the Pediatric Quality of Life Inventory Version 4.0 in participants ages 5–17 and 36-Item Short Form Survey for young adults aged 18–25. A subset of 27 participants completed face-to-face interviews to supplement quantitative findings.
Results: Eighty-six pediatric (age 5–17) sibling and parent pairs completed Peds QOL surveys, and 29 young adult (age 18–25) sibling pairs completed SF-36 surveys. One third of patients had surgery in Uganda. Ventricular septal defects and tetralogy of Fallot were the most common diagnoses. Health-related quality of life scores in patients were lower across all domains compared to control participants in children. Reductions in physical and emotional domains of HRQOL were also statistically significant for young adults. Variables associated with lower HRQOL score on multivariate analysis in pediatric patients were younger age in the physical and emotional domains, greater number of surgeries in the physical domain and surgery outside Uganda in the school domain. The only predictor of lower HRQOL score in young adults was surgery outside Uganda in the social domain. Qualitative interviews identified a number of themes that correlated with survey results including abandonment by family, isolation from peers and community, financial hardship and social stigmatization.
Conclusion: Health-related quality of life was lower in Ugandan patients after CHD surgery than siblings. Younger patients and those who had surgery outside of Uganda had lower HRQOL. These data have important implications for patients undergoing CHD surgery in LMIC and have potential to inform interventions.
The Modification and Psychometric Test of Anemia Complication Prevention Instruments Based on The Health Belief Model
Authors: Haryanti Priyani , Pandugaran Santhna Letchmi , Aljaberi Musheer A.
Published: April 2024

The high maternal mortality rate in middle-income countries is mostly caused by pregnancy complications, one of which is anemia in pregnancy. Behavioral instruments that use the health belief model are osteoporosis prevention, oral hygiene in pregnant women, and disaster preparedness. This instrument needs to be developed because based on previous literature searches it has not shown how the health belief model concept can be used to help pregnant women prevent anemia complications. This research aims to test the construct validity and reliability of the modified questionnaire for preventing anemia complications based on the health belief model. An internal validity test was conducted in Yogyakarta. Five specialists from different health fields - nurses, midwives, nutritionists, health promotion experts, and medical doctors- participated in the study. Some of the things that were done were as follows: 1) defining appropriate concepts and objectives; 2) defining and identifying domains; and 3) defining and creating items. 4) creating the measuring instrument, 5) finalizing the translation with the help of two native English speakers 7) preparing the test instrument for the content validity test, 6) running the validity test with five medical professionals, 7) Applying the Index of Content Validity (I-CVI) to the analyses. 8) Using Cronbach's alpha to conduct a reliability test on thirty pregnant women. The content validity index of the crucial indicator of behavioral prevention of consequences from anemia is one, and the relevance indicator also returns one, resulting in a total score of 0.99. Expert agreement in English has a kappa value of 0.442. Results of reliability using Cronbach's alpha of 0.807. The instrument for preventing anemia issues in pregnant women is valid and reliable, according to the study's findings.
Ensuring Safety in Industrial Robots: Issues, Consequences and Solutions
Authors: Pedro Francisco
Published: April 2024

In this paper, a discussion of the safety issues in robotics are provided, categorizing them into three major origins: unfavorable environmental factors; human errors, and technical deficiencies. Information related to robotic accidents was retrieved from the Ministry of Employment and Labor (MOEL) and Korea Occupational safety and Health Agency (KOSHA) in Korea. Accidents are classified into root and direct causes, and these causes are reviewed through the application of the Systematic Causal Analysis Technique (SCAT). This research continues to emphasize that the risks, such maintenance of people, and robotic operations, are the most susceptible during interactions with robots. The research explores the classification of accidents in robots, causes of injuries, and the necessity for personalized safety measures. In addition, it presents a discussion of the lack of assurance, safeguards, and confidentiality aspect in robotics, and the detrimental effect this has on enterprises. Lastly, the paper highlights the effects of industrial robot mishaps, such as human injuries and casualties, data privacy and breach apprehension, and effects of corporate brand. It explores the safety concerns and measures from legislation emphasizing the necessity of establishing a balance between security and efficiency.
Effectiveness of The Islamic Development Bank (IDB) in Promoting Development in Muslim Countries
Authors: Robbani Azzam
Published: April 2024

This research investigates the relationship between the Islamic Development Bank (IDB) and its support for Muslim nations, delving into funding allocations, SDG progress, and Shariah compliance across pre-defined regional categories. We employ statistical analysis to illuminate the landscape of development within these diverse geographies, revealing significant disparities in IDB funding, SDG progress, and the advancement of Islamic finance across regions. Our findings suggest that the IDB should prioritize resource allocation based on need and potential impact, ensuring equitable access across all Muslim-majority regions. Focusing on countries lagging in SDG progress or Islamic finance development could be particularly impactful. Additionally, the IDB can strengthen its role by innovating and promoting Islamic finance instruments, fostering financial inclusion and economic growth. Investing in research and education pertaining to Islamic economics and finance will further augment knowledge and expertise, ensuring the sustained growth of the sector. By prioritizing funding, exploring innovative financing mechanisms, and focusing on these key areas, the IDB can effectively catalyze positive change in Muslim countries, contributing to overall development and the growth of the Islamic economics ecosystem.
The Presence and Antibiotic Resistance of Non-O157 STEC on Lamb Carcasses
Authors: Koçak Kızanlık Pelin , Sahıner Cemil , Göksoy Ergün Ömer
Published: April 2024

There is an increasing trend in the prevalence of Hemolytic Uremic Syndrome (HUS) both in Türkiye and in the world. HUS might be caused by Shiga toxin (Stx)-producing Escherichia coli (STEC) O157 and strains of non-O157 STEC. The feces and fleece of lambs, and non-hygienic conditions present in the lamb slaughtering process are the main sources for STEC contaminations of lamb carcasses. In this study, the prevalence of STEC on lamb carcasses and, as an important global public health issue, the antibiotic resistance profiles of STEC strains isolated were aimed to be determined. The presence of stx was considered as STEC indicator. 16% of the carcasses (8/50) were found to be contaminated by E. coli. The analysis showed that none of the strains isolated were O157 serotype. But, 5 out of 8 strains isolated carried stx1 and stx2 genes so they were identified as non-O157 cytotoxigenic E. coli. Antibiotic resistance profiles of the isolates were determined by using Kirby Bauer method. All of the isolates were found to be resistant at least one antibiotics investigated, and as the most resistance rate found 87.5% of the isolates were resistant to both gentamycin and pefloxacine. In addition, 75% of the isolates were multidrug resistant (MDR), and overall MAR (Multi Antimicrobial Resistant) index of isolates was 0.4. As a result, STEC contamination on lamb carcasses was considered to be a risk for both children and adults for HUS, and high antibiotic resistance of the isolates observed also increased the public health hesitations. Reassessment of the slaughtering process based on the HACCP (Hazard Analysis and Critical Control Points) requirements and taking necessary actions/measures to control cross contaminations are thought to be crucial steps to reduce pathogenic bacteria incidence in food chain.
A New Approach for Solving Singularly Perturbed Boundary Value Problems by Using Exponential Spline Method
Authors:   Department of Mathematics, College of Education, University of Sumer, Thi-Qar, Iraq., Ahmed Ahmed
Published: April 2024

This article presents the development of families of approaches for numerically solving singularly perturbed two-point boundary-value problems using exponential spline functions. The proposed approaches exhibit second-order and fourth-order accuracy and are suitable for both singular and non-singular problem scenarios. Numerical data are presented to demonstrate the efficacy of our methodologies and are compared with those proposed by various writers.