bluuebunny/crossref_metadata_2025 huggingface dataset:
Individual factors associated with workaholism among Tunisian engineers
Authors: Bouaziz A. , Sallemi R. , Bouhamed M. , Guermazi F. , Feki I. , Masmoudi J.
Published: September 2022

Introduction

Globalization and increased competition in the engineering profession induce to work longer and harder, which predisposes to workaholism or work addiction. Identifying individual factors associated with workaholism could help to maintain the mental health at work.

Objectives

The aim of this study was to assess the prevalence of workaholism and its associated socio-demographic and historic factors among Tunisian engineers.

Methods

A cross-sectional descriptive and analytical study conducted among Tunisian engineers during July 2021. The data were collected by an online questionnaire including the socio-demographic and historic information and the “the Work Addiction Risk Test” (WART) which was used to assess the workaholism.

Results

A total of 52 engineers participated in this study (40.4% female and 59.6% male). The average age was 30.75 years (SD=6.25 years). Concerning marital status, thirty-five engineers (67.3%) were single. Of the participants, 17.3% had a history of chronic somatic-disorders and 25 % of them had a history of a psychiatric disorder, such as depressive disorder in 11.5% of cases. The prevalence of workaholism in Tunisian engineers was 23.1%. Workaholism was associated to older age with no significant difference (p = 0.11). The analysis showed that workaholics had more history of depressive disorder (p = 0.02) compared to non-workaholics. However, no significant difference was found by the other socio-demographic factors according to workaholism.

Conclusions

Workaholism is a significant phenomenon among Tunisian engineers. It may depend of personal characteristics and induce negative consequences on mental health and lead to depression.

Disclosure

No significant relationships.
Childhood violence experience interacts with BDNF Val158Met polymorphism and modify internet addiction risk
Authors: Chuprova N. , Merkulova T. , Solovieva M. , Nikolishin A. , Trusova A. , Grechany S. , Soldatkin V. , Yakovlev A. , Ponizovsky P. , Ilyuk R. , Egorov A. , Krupitsky E. , Kibitov A.
Published: September 2022

Introduction

Internet-addiction (IA) is one of the most common non-chemical (or behavioral) addictions with genetic impact and substantial effects of psychological and personality characteristics, taking into account the childhood traumatic experience. Gene-environment interactions (GxE) may substantially impact on the risk of Internet-addiction (IA).

Objectives

Aim: to test the associations between the functional polymorphism rs6265 (Val66Met) in brain-derived neurotrophic factor (BDNF) gene, affecting BDNF function, and childhood traumatic experience and their GxE interactions with IA risk.

Methods

In total 456 participants were screened with Chinese Internet Addiction Scale (CIAS) to cut a cohort on two groups: IA (CIAS total score ≥ 65, n=100) and controls (CIAS total score less 64, n=356). The Adverse Childhood Experiences International Questionnaire (ACE-IQ) was used to assess childhood traumatic experience using its main domains: parents (P), family (F), abuse (A) and violence (V). BDNF Val158Met polymorphism was detected by RT-PCR.

Results

Logistic regression revealed associations of P scores with increased IA risk only after adjustment for sex and age (p=0.01, OR=1.166, 95%CI[1.038-1.309]) and V scores with decreased IA risk (p=0.000, OR=0.799, 95%CI [0,233;0,744] only before adjustment. No associations of F and A with IA risk were found. BDNF Val158Met per se was not associated with IA risk, but significant effect of interaction V score*BDNF rs6265 CC on IA risk in “protective” manner was revealed (р=0.039, OR=0.873, 95%CI[0.768-0.993]) in a model adjusted for sex and age.

Conclusions

Childhood violence experience interacts with BDNF Val158Met polymorphism and CC (ValVal) genotype may be possibly protective factor decreasing the internet addiction risk

Disclosure

This work was carried out with the financial support of the Russian Foundation for Basic Research: RFBR grant # 18-29-22079
Gaming Disorder: looking for a specific psychopathological profile in a Russian sample
Authors: Dovbysh D. , Bogacheva N. , Epishin V.
Published: September 2022

Introduction

ICD-11 describes Gaming disorder as a behavioral pattern characterized by impaired control over gaming, increased gaming priority, and escalation despite consequences. This description is similar to other addictive behaviors with minor specifics. However, it is unclear if gaming disorder has any specific psychopathological profile.

Objectives

The study aimed to investigate gaming disorder’s connection to primary psychopathological symptomatology.

Methods

515 gamers aged 16-56 (75% male) anonymously completed online questionnaires: SCL-90-R and Video Games Addiction Scale (VGAS) – our new 26-items questionnaire based on ICD-11 criteria for gaming disorder. VGAS showed good reliability (Cronbach`s α=0.858) and external validity (positive correlation with Chen Internet Addiction Scale, r=0.472, p=0.000).

Results

Gaming disorder severity showed positive correlations (p=0.000) with all SCL-90-R scales. Pearson`s r ranged from 0.311 (phobic anxiety) to 0.431 (depression). Thus, gaming disorder showed no specific combination of psychopathological symptoms. Instead, all symptoms had almost equal correlations with the VGAS score.

Conclusions

Gaming disorder is not linked to any particular combination of psychopathological symptoms. On the contrary, as suggested by our study, different symptoms are almost equally related to excessive gaming. Several interpretations are possible. Problematic gaming can be a way for psychologically distressed people to deal with different symptoms. Conversely, gaming disorder can itself lead to psychological maladjustment. Thus, further thorough research is required, specifically when deciding on the primary diagnosis in comorbid cases or choosing the therapeutic aims.

Disclosure

No significant relationships.
Effectiveness of oral versus long-acting antipsychotic treatment early-phase schizophrenia patients: an open-label randomized trial
Authors: Winter I. , Davidson M. , Fleischhacker W. , Kahn R.
Published: September 2022

Introduction

Schizophrenia is a chronic psychiatric illness with periods of remission and relapse. Patients vary in the frequency and severity of relapse, time until relapse and time in remission. Discontinuation of antipsychotic medication is by far the most important reason for relapse. A possible method to optimize medication adherence is to treat patients with long-term, depot medication rather than oral medication.

Objectives

Primary objective is to compare all cause discontinuation rates in patients with schizophrenia randomized to either one of the two depot medications (aripiprazole depot or paliperidone palmitate) with patients randomized to either one of the two oral formulations of the same medication (aripiprazole or paliperidone) over an 19 month follow-up period.

Methods

Pragmatic, randomized, open label, multicenter, multinational comparative trial consisting of a 19 month treatment period. Patients aged 18 years or older, having experienced the first psychosis 1-7 years ago, currently meeting DSM-IV-R criteria for schizophrenia. Patients are randomized 1:1:1:1 to paliperidone palmitate, aripiprazole depot, oral aripiprazole or oral paliperidone. The primary outcome is all cause discontinuation.

Results

In the Intent to Treat sample (n=511), no difference was found in time to ACD between the combined oral and combined depot treatment arms, nor between the four individual treatment arms.

Conclusions

Even though the scientific evidence comparing oral and depot medication has been inconsistent, most studies were conducted in rigorous clinical settings, which may have biased those results. In contract, given the pragmatic, open label design of the current trial, the results may be more representative of common daily practice.

Disclosure

No significant relationships.
Lifestyle intervention on psychotherapy and exercise and their effect on physical and psychological health in outpatients with schizophrenia spectrum disorders. A pragmatic clinical trial
Authors: Fernández-Abascal B. , Suárez-Pinilla P. , Cobo-Corrales C. , Crespo-Facorro B. , Suarez-Pinilla M.
Published: September 2022

Introduction

Patients with Schizophrenia Spectrum Disorders (SSD) often lead unhealthy lifestyles with higher prevalence of obesity and unfavourable cardiometabolic parameters with less life expectancy and often worse quality of life compared with general population.

Objectives

Evaluate the effectiveness of a combined intervention of exercise and psychoeducation in 48 SSD outpatients with metabolic syndrome (MetS), treated with second-generation antipsychotics and also aimed to explore if the effect persisted in a long-term follow-up of 24 months.

Methods

The intervention included a 12-week aerobic exercise program and a session of lifestyle psychoeducation. Effectiveness was measured in terms a wide range of outcomes involving physical and psychological health, functioning, quality of life, physical activity and changes in motivation to exercise in the context of the self-determination theory.

Results

The active intervention group showed benefits after Bonferroni correction over clinical global impression, identified motivation to exercise and changes of physical activity pattern. Maintenance of effects after 24 months of follow-up was observed for identified regulation to exercise and also for negative symptoms of psychosis (Table). Table. Effects assigned-group/time-over *p≤0.05 **p≤0.01.
Variables12weeks24monthsTimeGroupxtimeGroupx timex gender
p
p
p
ppHDL (mg/dl)0.021*Negative Syndrome Scale0.044*0.004**BREQ-2- Extrinsic regulation0.008**0.004**-External0.026*-Introyected0.038*-Identified0.018*0.015*0.003**0.002**BREQ-2-Intrinsic regulation0.005**0.004**Pedometer (steps/day)0.001**0.006**

Conclusions

A combined intervention on SSD outpatients with MetS showed effectiveness over several clinical parameters and functioning. Therefore, should be considered an essential part of the integral treatment in mental health services for SSD patients.

Disclosure

No significant relationships.
Implementation of a lifestyle and life-skills intervention to prevent weight-gain and cardiometabolic abnormalities in people with first-episode psychosis: the Keeping the Body in Mind program
Authors: Curtis J. , Teasdale S. , Morell R. , Wadhwa P. , Lederman O. , Fibbins H. , Watkins A. , Ward P.
Published: September 2022

Introduction

The development of obesity and metabolic abnormalities that seed future ill-health occur early with antipsychotic treatment. In 2013, the 12-week Keeping the Body in Mind (KBIM) pilot lifestyle intervention was delivered to a small sample of youth experiencing first-episode psychosis (FEP) with <4 weeks of antipsychotic exposure in a cluster-controlled design. The control group experienced significant increases in weight (mean 7.8kg) and waist circumference (mean 7.1cm) compared to non-significant increases (mean 1.8kg) in the KBIM group.

Objectives

To evaluate the effect of KBIM as routine care on anthropometry and metabolic biochemistry in a larger sample of youth with FEP across three mental health services.

Methods

This retrospective chart audit was conducted on youth with FEP, prescribed a therapeutic dose of antipsychotic medication, and who engaged with KBIM between 2015 and 2019. Primary outcomes were weight and waist circumference. Secondary outcomes were blood pressure, blood glucose and blood lipids. Outcomes were collected in a pre-post design. Implementation elements were also obtained from the participant’s medical file.

Results

One-hundred and eighty-two people met inclusion criteria. Follow-up data were available on up to 134 people for individual outcomes. Mean number of sessions attended was 11.1 (SD=7.3). Weight and waist changes were limited to 1.5kg (SD=5.3, t(133)=3.2, p=0.002) and 0.7cm (SD=5.8, t(109)=1.2, p=0.23). Nineteen percent experienced clinically significant weight gain. There were no changes to blood pressure or metabolic biochemistry.

Conclusions

The positive outcomes for weight and waist circumference found in the initial pilot study were maintained with implementation as routine care.

Disclosure

No significant relationships.
Psychedelic Psychiatry
Authors: Nutt D.
Published: September 2022

The last decade has seen a remarkable resurgence of interest in psychedelic drugs such as psilocybin (from magic mushrooms) LSD and DMT (dimethyl tryptamine – the active ingredient of ayahuasca). This has been driven by the discovery that these psychedelics all act agonists of
5-HT2A receptors. Human imaging studies have revealed this action leads to profound alterations in brain measures of activity particularly in terms of increased entropy of EEG MEG and fMRI signals and reduced within-network, but increased between-network, connectivity. In addition they all can increase synaptic growth and brain plasticity. These findings not only explain the subjective nature of the psychedelic experience but also have implications for the treatment of internalising disorders such as depression addiction anorexia and OCD that are characterised by increased within network connectivity especially of the default mode network. Subsequent trials, particularly of psilocybin, in these disorders has revealed significant clinical benefits from even just a single administration. A number of companies have now been set up to extend these discoveries with regulatory-level trials that could result in market authorisations within a few years. My talk will explore these brain mechanisms and clinical data and discuss the potential place of psychedelic medicine in the future of psychiatry.

Disclosure

I am an advisor to Compass pathways and Beckley Psytec two companies that are developing psychedelics for depression and other psychiatric indications. Several members of my research group receive support from these companies and also from Small Pharma.
Child abuse during COVID-19 pandemic: what we can see
Authors: Reina F. , Vitrano F.
Published: September 2022

Introduction

COVID-19 caused an ongoing health emergency that rapidly spread worldwide, so all countries adopted exceptional health measures to reduce disease’s transmission. The stress caused by pandemic presents increasing risks for family violence and for child abuses. Interinstitutional Equips of Abusive and Maltreatment (IEAM) deals with the management of abusive families in Palermo’s territory. IEAM starts evaluations after the interventions of the court solicited by a complaint filed by teachers, law enforcements or members of the family. IEAM is formed by consultations in maternity ward, child welfare service and school educational psychologists.

Objectives

The purpose of this research was to evaluate the variations of child abuse and maltreatment reported during local and National lockdown due to pandemic. Reported cases were compared with the previous year.

Methods

The authors collected data of IEAM’s advisory from January 2019 until August 2021. The number of cases was evaluated monthly.

Results

We observed 124 cases in 2019, 145 in 2020 and 94 until August 2021. Advisory reductions coincided with the service activity reduction in August of every year and in March 2020 when Italy declared national lockdown. Social isolation represents a risk factor for child abuse. Although the increase of cases was quite stable, there are reasons to speculate that the reporting of child abuse and maltreatment decreased since home isolation hampered the access to responsible services.

Conclusions

School closure together with the strong reduction of social care and monitoring during and after lockdown might have increased the domestic violence. Lastly, the child abuse may be underreported despite the effective increase.

Disclosure

No significant relationships.
Cognitive Trajectory of COVID-19 and Long COVID in Adult Survivors
Authors: Vakani K. , Ratto M. , Sandford-James A. , Antonova E. , Kumari V.
Published: September 2022

Introduction

Cognitive functioning and psychological well-being are considered negatively affected by COVID-19. An estimated 15%-40% of COVID-19 patients report disrupted cognitive performance. Higher rates of anxiety, depression and sleep disturbances are also reported post infection.

Objectives

We examined the profile of cognitive changes in a group of adults with a confirmed COVID-19 diagnosis, compared to those without a COVID-19 diagnosis (cross-sectional between-subjects investigation); and for a subgroup, compared to their
pre-COVID-19 cognitive function (longitudinal within-subjects investigation).

Methods

One hundred and twenty-one adults (57 with no known history of COVID-19; 64 with confirmed COVID-19; 17/64 with long COVID symptoms) were assessed online for psychological well-being and cognitive function (attention, processing speed, working memory, episodic memory and executive function). Pre-COVID-19 cognitive data were available for 56 of 121 adults (24 adults with a confirmed diagnosis of COVID-19; 22 with no known history of COVID-19) through the MyCognition database.

Results

The COVID-19 group showed reduced processing speed in both cross-sectional and longitudinal investigations, and also showed significant attentional impairment when examined cross-sectionally. Five long COVID symptoms (abdominal pain, chest pain, sore eyes/conjunctivitis, sore throat and vomiting/nausea) were associated with reduced performance in multiple cognitive domains. Higher levels of depression and anxiety were also present in the COVID-19 group but these symptoms were mostly unrelated to cognitive performance.

Conclusions

COVID-19 survivors, especially those with long COVID symptoms, are very likely to experience cognitive disruption. Measures need to be implemented to support their cognitive recovery in addition to the physical recovery.

Disclosure

No significant relationships.
Transcultural Aspect of Mental Health Care
Authors: Schouler-Ocak M.
Published: September 2022

Culture is not simply the aggregate of individual traits but a more or less coherent system of shared meanings, institutions and practices (i.e. beliefs, attitudes and values). It is a repository of meaningful symbols that structure experience both implicitly and through explicit models. Culture shapes how and what psychiatric symptoms are expressed, influences the meanings that are given to symptoms and impacts the interaction between the patient and the health care system. Explanatory models are the ways in which individuals in different cultures see the core reasons of their suffering. The DSM-5 cultural formulation interview is developed to be used as clinical instrument and valuable tool. It is evident that phenomena such as the increasing migratory flows and the globalisation of prevailing social criteria referred to the economy, trade, religion and the perception and the attribution of the causes of disease have determined a shift in the world cultural balance that have direct repercussions on World Mental Health. More specifically, it needs to be seen how the transcultural differences in the personality configurations and psychological operations can be correlated with the cross-cultural differences in psychopathology to arrive at an understanding of these. Furthermore, understanding the central role of culture of mental health and illness must, therefore, be central to any vision of the future of psychiatry. In this presentation transcultural aspects of mental health care in psychiatry will be highlighted and discussed.

Disclosure

No significant relationships.
Different cultures and sexual unwellness in older adults: A qualitative study with older populations from Slovenia and Portugal
Authors: Von Humboldt S. , Rolo J. , Ribeiro-Gonçalves J.A. , Benko E. , Low G. , Leal I.
Published: September 2022

Introduction

Oder adults have been stereotyped (1), both explicitly and implicitly, as being asexual or naturally lacking sexual desires (2).

Objectives

The objective of this study is to analyse the perspectives of sexual unwellness (SU) of Portuguese and Slovenian older adults.

Methods

A qualitative research was carried out, in which these perceptions were analysed at a cultural level. Methods: The sample of this study consisted of 136 older participants, between 65 and 96 years of age. Participants were of two different nationalities and lived in the community. Participants were interviewed, and all interviews were carried out through the process of literal transcription and subsequent content analysis.

Results

Eight key mutually exclusive themes emerged from the interviews: unavailability of partner; traditional values; body restrictions; low self-esteem and well-being; poor social support; dissatisfaction with physical appearance; pain during sex; and difficulties meeting new people. Unavailability of partner was the most important theme (17.9%) for the studied sample and specifically among Portuguese participants. Conversely, difficulties meeting new people was the least reported theme (6.8%) for the entire sample. For Slovenians traditional values were most relevant with respect to feeling sexually unwell.

Conclusions

Older adults from two different countries reported diverse sexual experiences. Eight mutual-exclusive themes were extensively illustrated. 1.von Humboldt S et al. Sexual expression in old age: How older adults from different cultures express sexually? Sex Res Social Policy. 2020;1-15. 2.von Humboldt S et al. Are older adults satisfied with their sexuality? Outcomes from a cross-cultural study. Educ Gerontol. 2020;46:284-293.

Disclosure

No significant relationships.
Accessibility of migrants to mental health services
Authors: Zartaloudi A.
Published: September 2022

Introduction

Cultural barriers and prejudices of mental healthcare professionals may promote inequalities in the provision of care to immigrant population and have a negative impact in provided service quality.

Objectives

To identify barriers and facilitators of immigrants’ accessibility to mental health services.

Methods

A literature review has been made through PubMed database.

Results

Immigrants’ accessibility to mental health services may be related to social insurance problems, inadequate knowledge about their health rights, inadequate knowledge of the local language, as well as the bureaucracy of Greek State which may complicate mental health examination and treatment. The challenges faced by mental healthcare professionals in terms of diagnosis and treatment of migrants include communication difficulties due to linguistic and cultural differences as far as verbal presentation of symptoms and illness behavior is concerned. Culturally competent mental health professionals should work to erase racism and prejudice, to be familiar with cultural issues and have adequate knowledge related to cultural groups, to learn the life story of each patient separately and encourage patients to explain how their illness affects their lives, promoting a trustful communication environment in the context of healthcare provision.

Conclusions

Exploring the specific needs of migrants as well as assessing the degree of satisfaction from their access to healthcare services are essential to providing integrated mental health care for people from different culture.

Disclosure

No significant relationships.
Effectiveness of Posttraumatic Growth Interventions among Cancer Survivors: A Systematic Review and Meta-analysis
Authors: Üzar-Özçetin Y.S. , Öcalan S.
Published: September 2022

Introduction

Although cancer is a debilitating experience, it can also increase meaning and satisfaction in one’s life.

Objectives

To investigate the effectiveness of interventions that aim to develop posttraumatic growth among cancer survivors.

Methods

Seven databasis were searched for relevant articles published between 2000 and 2020. The findings of randomized controlled trials related to interventions to effect posttraumatic growth of cancer survivors were included. Hedges’ g and 95% confidence intervals were computed to estimate the effect.

Results

The effect of the interventions on posttraumatic growth among cancer survivors were heterogeneous. The effect size was statistically significant (Tables 1,2).Table 1
k
Total n
Hedges’g
SE
95% CI
z
p
Q ValueI2
Eggers tEggers p
Overall studiest7151.7610.484[0.812, 2.709]3.637< 0.001182.80796.7184.66.871Table 2Intervention EffectDesignStudieskTotal nHedges’gSE95% CIRCTOchoa-Arnedo et al. (2020)71400.1130.168[-0.217, 0.443]Üzar-Özçetin & Hiçdurmaz (2019)7613.9651.155[11.700, 16.229]Kenne Sarenmalm et al. (2017)1140.4230.189[0.053, 0.793]van der Spek et al. (2017)91-0.1610.208[-0.569, 0.247]Yun et al. (2017)1740.3310.162[0.014, 0.648]Zhang et al. (2016)582.0330.321[1.405, 2.662]Zernicke et al. (2014)621.2540.275[0.715, 1.793]

Z = 3.637 P= < 0.001 SE = 0.484 Sd = 1.777

Conclusions

Posttraumatic growth interventions significantly increased posttraumatic growth among cancer survivors. Health care providers as the main sources of cancer care should be more focused on the achievement of positive outcomes.

Disclosure

No significant relationships.
Illness and tretment representation in onological patients undergoing chemotherapy: relationship with subjective well-being
Authors: Rasskazova E. , Kirsanova S.
Published: September 2022

Introduction

The knowledge, expectations, fears that a patient has about the oncological disease and treatment can affect the quality of life of patients (Colagiuri et al., 2013; Whitford, 2012).

Objectives

The aim was to reveal the relationship between well-being of patients with cancer undergoing chemotherapy and their illness and treatment representation.

Methods

110 patients undergoing chemotherapy in Medsi Clinical Hospital filled Chemotherapy Attitudes Questionnaire (Zinchenko et al., 2020), Life Satisfaction Scale (Diener et al., 1985), Scale of Positive and Negative Experience (Diener et al., 2009), Quality of Life Questionary C30 (Aaronson N. K. et al., 1994), Illness Perception Questionnaire (Moss-Morris et al., 2002), Self-Regulation Questionnaire in the Rehabilitation Process (Kovyazina M. et al, 2019), Hospital Anxiety and Depression Scale (Zigmond, Snaith, 1983).

Results

Correlation analysis revealed that patients with severe difficulties in physical functioning had a lower level of life satisfaction (R = -0.23, p <.05) and quality of life (R = -0.35, p <.001), perceived disease as long-term (R = 0.34; p <0.001), cyclical (R = 0.33; p <0.001) and carrying significant negative consequences for life (R = 0.55; p <0.001), also these patients were characterized by anxiety about health during treatment (R = 0.37; p <0.001).

Perception of illness duration, personal control, emotional representations, self-efficacy, confidence in the effectiveness of treatment can predict the level of satisfaction with life of cancer patients undergoing chemotherapy (R2 increased from 0.05 to 0.37, p<0.001).

Conclusions

Health anxiety, illness duration, personal control, self-efficacy could be targets for interventions in patients undergoing chemotherapy.

Disclosure

No significant relationships.
Tolerability of Ziprasidone Use in Children and Adolescents: A Prisma Model: Systematic Review and Meta-Analysis
Authors: Jay J. , Sareen A. , Hassan N. , Dumlao N. , Jose K. , Haza I. , Wadhwa A. , Gunturu S.
Published: September 2022

Introduction

Studies have demonstrated that Ziprasidone use may be beneficial in children. Determining its potential risks and benefits when used in children is therefore important.

Objectives

To examine the tolerability of Ziprasidone, an atypical antipsychotic, in children and adolescents.

Methods

We conducted a literature search of open label or randomized control trials that report on Ziprasidone use in children on three databases: Embase, PsychInfo and PubMed using the PRISMA guidelines of Systematic review and Meta-analysis. Out of 1690 articles, 11 studies met inclusion criteria. Outcome measures included adverse effects such as weight gain, increase in BMI, QTc prolongation, changes in metabolic parameters, sedation, and dizziness. We conducted a random effects meta-analysis and meta-regression of potential moderators. Publication bias was assessed with funnel plots.

Results

Data from Eleven studies was meta-analyzed (Total n= 474, mean age=12.87 years, male= 68..37%) that reported the use of Ziprasidone in children and adolescents with Psychosis, Bipolar, Autism spectrum disorders and Tourettes syndrome. Mean Ziprasidone dose = 84.40 mg and mean study duration = 2.85 months). We found that Ziprasidone was not found to cause any significant weight gain (1.72, p>0.05) or change in BMI (0.58 , p>0.05). QTc prolongation was found to be significant (11.9 , p<0.05). Most common side effects were sedation (42.44%), Nausea(19.32%), Headache (22.92%), fatigue (16.67%) and Dizziness (16.96 %).

Conclusions

Results demonstrate that Ziprasidone does not cause significant weight gain, however QTc prolongation and sedation were found to be significant side effects of Ziprasidone use. Therefore, baseline EKG and thorough history must be obtained before prescribing Ziprasidone in children and adolescents.

Disclosure

No significant relationships.
Longitudinal associations between problematic Internet use, self-esteem, and depressive symptoms among Chinese adolescents
Authors: Lai W. , Wang W. , Guo L. , Lu C.
Published: September 2022

Introduction

Adolescents spend more time on the Internet than adults, making them susceptible to problematic Internet use (PIU). Evidence shows that PIU has a negative impact on self-esteem among adolescents, disturbing the development of emotional regulation, which makes them more likely to develop depressive symptoms subsequently. However, there is lack of literature focusing on the process that self-esteem may mediate the association between PIU and depressive symptoms.

Objectives

This study aimed to examine the prospective links between PIU, self-esteem, and depressive symptoms in adolescence.

Methods

A total of 1,736 adolescents completed this longitudinal study. The baseline survey was conducted in 2019, and the follow-up surveys were performed at 1-year and 2-year later. Problematic Internet use, self-esteem, and depressive symptoms were measured. A cascade model was used to examine the longitudinal associations between PIU, self-esteem, and depressive symptoms.

Results

The mean (SD) age of participants was 13.6 (1.5) years at baseline. The final results observed significant within-time associations between PIU, self-esteem, and depressive symptoms at each time point. PIU and low level of self-esteem could predict subsequent depressive symptoms among adolescents, and depressive symptoms were also associated with subsequent PIU and self-esteem.

Conclusions

Both problematic Internet use and self-esteem show bidirectional predictions with depressive symptoms among Chinese adolescents. Health-related professionals, schools and families should be aware of the findings of bidirectional associations. Adolescents with problematic Internet use and lower self-esteem should be paid more attention to attenuate the risk of developing depressive symptoms.

Disclosure

No significant relationships.
Bullying victimization in children and adolescents and its impact on academic outcomes
Authors: Vadukapuram R. , Trivedi C. , Mansuri Z. , Shah K. , Reddy A. , Jain S.
Published: September 2022

Introduction

Bullying is a serious problem in schools because of the negative impact on a child’s educational outcomes, especially academic achievement. However, the underlying mechanisms and causes are unknown.

Objectives

To evaluate the educational outcomes, and psychiatric comorbidities in children and adolescents who are victims of bullying

Methods

We used 2018–2019 Nationwide Survey of Children’s Health (NSCH) dataset for the study. The participants were children and adolescents (age: 6-17 years, n = 42,790). Data was stratified into two groups: 1) never bullied 2) bullied more than once. Prevalence of different educational outcomes were compared between the groups.

Results

In the never bullied group 21,015 participants were included, and in the bullied more than once group 21,775 participants were included. More females were in the bullied group compared to never bullied group (50.4% vs 47.5%, p=0.006). More White non- Hispanic individuals were in bullied group in contrast to never bullied group (56.7% vs 43.9%, p< 0.001). Individuals whose health status was fair, or poor were bullied more (2.4% vs 1.4%, p=<0.001). Individuals in bullied group were more likely to be repeating the grades compared to the never bullied group (7.1% vs 5.9%, p:0.039). Individuals who were missing >=11 school days, and sometimes or never engaged in school were observed more in bullied group compared to never bullied group (5.9% vs 3.2% and 20.3% vs 10.6% p < 0.001).

Conclusions

Our findings suggest that bullying victimization could be a risk factor and associated with decreased academic outcomes.

Disclosure

No significant relationships.
Childhood and recent maternal adverse experiences and mother-infant attachment influence early newborns’ neurobehavioural profiles
Authors: San Martín N. , Castro Quintas Á. , Daura-Corral M. , Marques Feixa L. , Eixarch E. , Crispi F. , De La Fuente Tomas L. , Garcia-Portilla M.P. , Fañanas L.
Published: September 2022

Introduction

Maternal stress during pregnancy influences fetal neurodevelopment, especially by the dysregulation of the HPA axis. However, less is known about whether maltreatment or stressful life experiences previous to pregnancy influence on developmental outcomes in the offspring.

Objectives

To analyze newborns’ neurobehavioral profiles in a cohort of healthy pregnant women, according to 1) childhood and recent maternal adverse experiences and 2) mother-infant attachment.

Methods

150 women were followed during the three trimesters of pregnancy. CTQ and AAT tests were employed to evaluate childhood and recent experiences of maltreatment, while infant and recent adverse experiences were evaluated using ETI-SR and SRSS, respectively. Newborns neurobehavioral profiles were defined at 8 weeks using the Neonatal Behavioral Assessment Scale (NBAS) and their temperament was assessed with IBQ. PBQ and PAI scales were employed to assess mother-infant attachment. A linear regression model was performed, adjusting for possible confounders.

Results

Maternal childhood sexual abuse seems to be associated with greater difficulties in the newborns control of reactivity to external stimuli (β=0,517; p-value=0.001), while recent maternal stressful experiences are related to difficulties for states regulation (β=0,29; p-value=0,038). Regarding attachment, maltreated mothers tend to show ambivalent and avoidant styles. Interestingly, postnatal mother-infant attachment seems to modulate autonomous, motor and social-interactive abilities in the offspring (β=-0,227; p-value=0,033 // β=-0,329; p-value=0,006).

Conclusions

Newborns from mothers exposed to maltreatment and negative life events previous to pregnancy show difficulties to organize and regulate the reactions to psychosocial stimuli. Future studies must disentangle whether maternal attachment style is a modulator of this association.

Disclosure

No significant relationships.
Association of genetic variants of Glutamate Metabotropic Receptor 5 gene and state-anhedonia
Authors: Török D. , Gonda X. , Gal Z. , Eszlari N. , Bagdy G. , Juhasz G. , Petschner P.
Published: September 2022

Introduction

Andedonia is one of the core symptoms of depression. It is known that in case of depressed individuals experiencing anhedonia, the classical antidepressants are often ineffective, thus investigation of this symptom would be essential. Recent studies highlight the possible role of the glutamatergic system in anhedonia however, the genetic background of these assumptions is still unclear.

Objectives

Our goal was to investigate the possible associations between state-anhedonia and genetic variants from GRM5 (Glutamate Metabotropic Receptor 5) gene.

Methods

For our analysis we used data from the NewMood (New Molecules in Mood Disorders, LSHM-CT-2004-503474) project. Participants (n = 1820) aged between 18-60, were recruited in Budapest and in Manchester. All volunteers filled out mental-health questionnaires and provided DNA sample. Genotyping was performed by Illumina’s CoreExom PsychChip. Altogether 1282 variants from GRM5 gene survived the genetic quality control steps. State-anhedonia was measured with an item from the Brief Symptom Inventory questionnaire. We performed logistic regression using Plink 2.0. During our analyses, age, gender, population and the top10 principal components of the genome were added into the model as covariates. Correction for linkage-disequilibrium were performed with LDlink.

Results

After the correction of linkage-disequilibrium, three independent variables (r2<0.2), (rs1827603, rs6483520, rs35669869) yielded significant (p<0.05) results, both in additive and in dominant model. In case of recessive model, only rs11020880 showed significant (p<0.05) effect.

Conclusions

The detected nominally significant associations between state-anhedonia and genetic variants from GRM5 gene strengthen previous assumptions about the possible relationship between glutamatergic system and anhedonia.

Disclosure

This study was supported by: MTA-SE Neuropsychopharmacology and Neurochemistry Research Group; 2017-1.2.1-NKP-2017-00002; KTIA_13_NAPA-II/14; KTIA_NAP_13-1-2013- 0001; KTIA_NAP_13-2- 2015-0001; 2020-4.1.1.-TKP2020 and 2019-2.1.7-ERA-NET-2020-00005 (TRAJEC
Links between posterior pituitary activity, psychometric profile and other endocrine abnormalities in anorexia nervosa: a multimodal evaluation
Authors: Doua S. , Jérôme R. , Traverse B. , Zennadi M. , Boutet C. , Hammour A. , Germain N. , Massoubre C. , Galusca B.
Published: September 2022

Introduction

Opioid system activity was found disturbed in several reward circuit areas in restrictive anorexia nervosa (AN) patients but also at the pituitary level. The role of this specific abnormality in AN physiopathology remains unknown.O

Objectives

We aimed to evaluate the relationship of upper mentioned AN abnormality with its classical pituitary features and eating behavior traits.

Methods

PET [11C] diprenorphin binding potential (BPND) were processed for each pituitary part in three groups of young women: 12 AN, 11 recovered AN patients (ANrec), and 12 Controls. Anterior pituitary hormones and neurohypophysis (NH) 12 points circadian profile including copeptin and oxytocin, psychological scores were evaluated in these subjects as well as in 13 bulimic (BN) patients.

Results

[11C] diprenorphin pituitary binding was found to be fully localized in NH. Only AN patients’ NH present lower [11C] diprenorphin BPND than Controls, interpreted as a higher opioid tone. Both AN and ANrec show lower copeptin/24h than in Controls but no difference in oxytocin. BN showed increased copeptin and low oxytocin. In AN patients copeptin inversely correlate with Restrained Eating while oxytocin correlate with the External Eating score. NH [11C] diprenorphin BPND correlated with leptin but not with copeptin or oxytocin.

Conclusions

Neurohypopysis opioid tone in anorexia nervosa seem not to impact the vasopressin or oxytocin release but still may interfere in gonadal axis regulation. Copeptin, a good indicator of hydration state, may be a good tool to detect hidden restrictive or purging behaviors. Specific correlates with AN psychologic features still suggest a physiopathological involvement.

Disclosure

No significant relationships.
Eating behaviour among adults with different levels of emotional suppression and eating disorder symptomatology
Authors: Brytek-Matera A. , Czepczor-Bernat K. , Bronowicka P. , Modrzejewska A. , Modrzejewska J. , Szymańska P. , Waliłko J.
Published: September 2022

Introduction

Research has shown that emotional suppression, a form of emotion regulation, is often used by individuals with disordered eating behaviour. Moreover, eating disorder symptomatology is associated with inappropriate eating behaviours (e.g. excessive consumption of high-calorie foods and comfort foods).

Objectives

The objective of the present study was to investigate the differences in eating behaviour among adults with different levels of emotional suppression and eating disorder symptomatology.

Methods

Two hundred seventy adults (Mage = 29.44 ± 9.32) completed the Three-Factor Eating Questionnaire (eating behaviour), the Eating Attitudes Test (eating disorder symptomatology) and the Emotion Regulation Questionnaire (emotional suppression).

Results

Three clusters were identified through cluster analysis: cluster 1 (N = 115) presenting low emotional suppression and low eating disorder symptomatology; cluster 2 (N = 43) presenting high emotional suppression and high eating disorder symptomatology and cluster 3 (N = 112) presenting high emotional suppression and low eating disorder symptomatology. Our results showed that individuals in cluster 2 had significantly greater levels of cognitive restraint, uncontrolled eating and emotional eating than individuals in clusters 1 and 3. Moreover, individuals in clusters 1 and 3 did not differ significantly in terms of any of the TFEQ subscales.

Conclusions

These preliminary findings may suggest that the tendency to persistently suppress emotions exacerbate disordered eating behaviour. Therefore, this factor together with symptoms of eating disorders should to be considered when planning prevention and intervention programs among adults presenting disordered eating behaviour.

Disclosure

No significant relationships.
Is decision-making impairment an endophenotype of Anorexia Nervosa?
Authors: Di Lodovico L. , Lachatre M. , Marcheselli J. , Versini A. , Ramoz N. , Gorwood P.
Published: September 2022

Introduction

Patients with anorexia nervosa (AN) show impaired decision-making ability, but it is still unclear if this is a trait marker, i.e. a stable endophenotype of AN, or a state parameter, i.e. being explained by present symptoms and associated comorbidity.

Objectives

We aimed to determine whether decision-making impairment is an endophenotype of AN. We hypothesized that decision-making alteration would not respect the criteria of an endophenotype, and that these alterations would have a relationship with illness severity.

Methods

Ninety-one patients with acute AN (A-AN), 90 unaffected relatives (UR), 23 patients remitted from AN (R-AN) and 204 healthy controls (HC) underwent the Iowa Gambling Task (IGT) and psychometric assessments. Prospective Valence Learning model (PVL) was employed to distinguish the cognitive dimensions underlying the decision-making process. Performance at the IGT was compared between the four groups and then analysed according to clinical and psychometric variables.

Results

Patients with A-AN scored worse than UR and HC at the IGT (p<.01). PVL-feedback sensitivity parameter was lower in patients with R-AN and A-AN than in the two other groups (p<.01) and PVL-loss aversion parameter was lower in A-AN than in UR and R-AN (p<.01). Decision-making style, in particular learning and loss aversion parameters, accounted for a significant part of variance of psychopathology in patients with AN (p<.01).

Conclusions

Impaired decision-making represents a state-associated, cognitive hallmark of AN. The aggravation of reward modulation along with illness progression may explain the persistence of symptoms despite their consequences on health. Reversal of decision-making impairment should not be limited by inherited vulnerability.

Disclosure

No significant relationships.
Vulnerability to acute psychosocial stress in subjects with eating disorders and history of childhood trauma: experimental evidence of a “Maltreated Ecophenotype”
Authors: Barone E. , Carfagno M. , Monteleone A.M. , Ruzzi V. , Pellegrino F. , Marafioti N. , Toricco R.
Published: September 2022

Introduction

Subjects with eating disorders (ED) show a high prevalence of childhood trauma.

Objectives

Aim of the study is to evaluate the emotional, biological and behavioral responses to an experimental acute psychosocial stress in subjects with ED with or without childhood maltreatment. Secondary aim is to evaluate the effects of different traumatic experiences (physical and emotional).

Methods

48 women with ED completed the Childhood Trauma Questionnaire (CTQ). 29 participants (14 with Anorexia Nervosa [AN] and 15 with Bulimia Nervosa [BN]) reported an history of childhood maltreatment, while 19 (11 with AN and 8 with BN) did not. Cortisol levels, anxiety and hunger perceptions have been assessed in all participants throughout the Trier Social Stress Test (TSST) as well as body dissatisfaction after stress exposure.

Results

Subjects with childhood trauma showed higher emotional reactivity and body dissatisfaction and lower hunger throughout the TSST than those without childhood trauma. Higher cortisol levels were observed in patients with AN, regardless of the presence of childhood trauma, and in those with BN and history of emotional trauma. Emotional trauma was the childhood trauma explaining most of the observed differences.

Conclusions

Childhood trauma, especially emotional one, can lead to vulnerability to interpersonal stress in individuals with ED. The present study is the first that supports the “maltreated ecophenotype” hypothesis in subjects with ED through an experimental task and the evaluation of multiple levels of response. These data may provide new prospectives on the pathogenetic mechanisms of ED and novel therapeutic implications.

Disclosure

No significant relationships.
Bulimia nervosa and borderline personality disorder - case report and literature review
Authors: Borges A. , Machado D.
Published: September 2022

Introduction

Bulimia Nervosa (BN) is a debilitating eating disorder characterized by binging and purging episodes generally accompanied by excessive concern with body weight and shape as well as body image disturbance. BN and Borderline Personality Disorder (BPD) may co-occur. In fact, studies estimate that one quarter to one third of patients with BN also meet criteria for BPD. However not much is known about the relationship between these two diseases. Nevertheless, the high comorbidity rate might not be surprising as both BN and BPD may share interacting aetiologies and common core symptoms such as impulsivity and emotional instability. So far, only very little is known about the clinical presentation of patients with both BN and BPD and their response to treatment.

Objectives

Literature review on BN and comorbid BPD. An illustrative clinical case is presented.

Methods

Case report and non-systematic review of the literature - sources obtained through search on Pubmed.gov database.

Results

Female, 19-year-old, student, lived with her mother and stepfather. Developed a poor relationship with her body image due to dental problems during high school. The patient started to binge eat, exhibit compensatory behaviors, restrictive eating pattern, body dissatisfaction and emotional instability while maintaining a normal BMI. Over the last year, she started a self-destructive behavior with slight improvement of BN symptoms.

Conclusions

Special attention should be given to patients suffering from BN and comorbid BPD as they present greater risk of recurrent suicide attempts and non-suicidal self-injury, as well as lower rates of remission. Early interventions that target impulsivity and problematic eating behavior may mitigate risk of future borderline personality features.

Disclosure

No significant relationships.