bluuebunny/crossref_metadata_2025 huggingface dataset:
Representaciones discursivas de las violaciones a los derechos humanos durante el estallido social: un análisis comparativo de ciberprensa chilena e internacional
Authors:   , Hurtado Pavez Millaray
Published: April 2024

En la presente investigación se realiza un análisis comparativo de las representaciones sobre las violaciones a los derechos humanos ocurridas durante el Estallido Social chileno de 2019 en medios de ciberprensa chilena y ciberprensa internacional, desde la perspectiva del análisis crítico del discurso (ACD) en conjunto con la Lingüística de Corpus (LC). El corpus de análisis se compone de noticias provenientes de seis medios de ciberprensa chilenos en español (El Mercurio, El Mostrador, La Tercera, CNN, Radio Universidad de Chile y CIPER) y seis medios de ciberprensa internacionales que cuentan con páginas web en inglés (Al Jazeera, The Guardian, BBC, Deutsche Welle, NACLA y Reuters). Los datos fueron procesados con la plataforma de LC Sketch Engine y posteriormente analizados siguiendo la metodología para ACD de Pardo Abril (2013). A partir del análisis cuantitativo, basado en la búsqueda de unidades léxicas clave vinculadas a violaciones a los derechos humanos, se desprenden cinco categorías de violaciones a los derechos humanos presentes en los corpus en español y en inglés, estas son: muertes, lesiones, tortura, violencia sexual y detenciones. Posteriormente, se describen y comparan los principales contextos de uso de las unidades léxicas asociadas a estas categorías. Se concluye que las diferencias más significativas en cuanto a las representaciones discursivas de cada corpus se relacionan con la predominancia de distintas estrategias lingüísticas en los textos: por un lado, se identificó una tendencia en la ciberprensa internacional a estrategias de inclusión, principalmente en cuanto a la integración explícita de los agentes responsables de las violaciones a los DDHH; mientras que en el corpus de prensa chilena predominaron las estrategias de elisión y segmentación, de manera que se tiende a omitir a los agentes. Finalmente, se plantea como proyección un análisis del corpus enfocado exclusivamente en la agentividad, así como también se hace necesaria una caracterización ideológica de los medios seleccionados en ambos idiomas.
Influencia del contexto e información nutricional en la elección entre alimentos saludables y no saludables
Authors:   , Caballero Vivanco Sara
Published: April 2024

Las personas se ven enfrentadas a un conflicto al tener que elegir entre alimentos palatables no saludables y saludables no tan sabrosos, pero no es claro como el contexto de elección y la información nutricional modulan este conflicto. En esta investigación se realizó un estudio online donde los participantes tuvieron que elegir entre imágenes de alimentos con y sin sellos en 3 contextos, entendiendo contexto como la intención de la persona al elegir el alimento. Estos contextos eran: salud (elegir alimentos que comerían para mantenerse sano), deseo (elegir alimentos que comerían si nada los detuviera) y típico (elegir alimentos que comerían en su vida diaria). Se encontró que el contexto es el factor que más influye en la efectividad de los sellos. Los sellos disminuyen el conflicto en elegir alimentos sin sellos frente a alimentos con sellos en todos los contextos, pero sólo en el contexto de salud los sellos aumentan el conflicto al elegir el alimento no saludable.
Neural dynamics of creative drawing
Authors:   , Cordero Roldán Evelyn
Published: April 2024

Creativity is a characteristic element of human cognition. At the brain level, the difference between creative and non-creative problem solving correlates with changes in alpha oscillatory activity. Although interesting, a weakness of these studies is the imbalance between the cognitive demands associated with the creative task (harder) and the control task (easier). This point casts doubt on whether alpha activity is indeed a marker of the creative process or rather is a general index of the cognitive demands of the task. To elucidate this issue, we compared the oscillatory brain response of subjects while performing two cognitively demanding drawing tasks, which differed only in the level of creativity required to execute them. Compared to the ideation of creative drawings, the ideation of conventional drawings induced a greater increase in alpha power, mainly over bilateral frontal and posterior regions. Furthermore, compared to low creative subjects, high creative subjects show a progressive increase in alpha power during the ideation phase, distributed across right frontoparietal and bilateral posterior sites. Taken together, these findings suggest task-specific allocation of cognitive resources over time, with greater cognitve control at the beginning and decreased control towards the end in more structured tasks, and conversely in tasks that demand creative problem solving. Future research should explore these dynamics further, particularly in relation to individual differences in creativity.
Indicadores de impacto social corporativo e a sua relevância na sociedade
Authors: Silva Mariana Ferreira da , Cavalcante Luis Felipe de Oliveira , Veras Elijerton Rogério Chaves
Published: April 2024

Um novo olhar tem sido desenvolvido nas organizações em busca de que seus negócios sejam lucrativos, mas que consequentemente o seu sucesso seja uma forma de impactar positivamente a sociedade na qual estão inseridos. Para isso, os indicadores de impacto social corporativo foram desenvolvidos como parâmetro para as empresas, inclusive, auxiliando nos seus processos de tomada de decisão. O objetivo dessa pesquisa consiste em investigar como os indicadores de impacto social podem contribuir para o desenvolvimento das empresas e qual a sua relevância na sociedade. Esta pesquisa foi realizada por meio de uma revisão da literatura sistemática, onde foi realizado a análise exploratória e qualitativa de artigos científicos, selecionados por meio de um levantamento bibliográfico que ocorreu nos sites de pesquisa acadêmica Portal de Periódicos Capes, SciELO e Google Acadêmico. Foram incluídos na pesquisa 5 artigos publicados nos últimos 5 anos, nos idiomas: português ou inglês; e que tinham a metodologia descritas de modo claro no resumo. Ao finalizar essa pesquisa, verificou-se que os indicadores de impacto social corporativo são essenciais tanto para o desenvolvimento dos negócios quanto para a sociedade por várias razões fundamentais, tais como as causas ambientais, diminuição da pobreza e desigualdade social, mudanças climáticas, entre outros, contribuindo para um mundo mais justo, sustentável e próspero para todos.
O desenvolvimento nacional, entre Daniel Munduruku e Celso Furtado: do paradigma econômico ao referencial cultural
Authors: Rocha Júlio César Barreto , Carneiro Patrícia Helena dos Santos , Silva Álexy Rodrigo Lima da , Régis Claudilene Souza Nascimento , Ferro Barbara Ellen do Nascimento , Souza Ingrid Bessa de
Published: April 2024

A partir da leitura de obras literárias e teóricas de Daniel Munduruku, percebem-se nas suas posturas diferentes teorias explicativas daquilo que seja o desenvolvimento, através da sua base cultural, mítica, ecológica, plural, reunida em diversas passagens da obra do autor indígena. Compreende-se, ademais, que a influência a um planejamento econômico-culturalista, detectado nessas posturas, perpassa uma visão derivada ainda do economista Celso Furtado. Os fundamentos dessas nossas pesquisas (construídas em projetos acadêmicos recebedores de bolsas do programa PIBIC em vários ciclos) levaram à escrita de uma dissertação de mestrado e à participação em alguns eventos, nos quais foi empregado o método político-cultural, de base epistemológica hipotético-dedutiva, e o objeto foi recortado de procedimentos metodológicos jurídico-literários. Ao aproximar e traçar diferenças entre essas teorias do desenvolvimento e os textos de Daniel Munduruku, uma perspectivação amazônida ganha forma, fazendo crer que a leitura de obras literárias, à luz de teorias econômicas como algumas abraçadas por Celso Furtado, pode identificar uma resultante econômico-cultural ao desenvolvimento nacional visando melhor combater problemas provenientes da enorme desigualdade do Brasil contemporâneo. O uso de teóricos de corte político, histórico ou culturalista (como Eagleton, Rocha e Godoy) permite trazer o texto literário sem comprometê-lo com exageros interpretativos sobre a obra de Munduruku, porque ressalta a fundamentação histórico-cultural de práticas de Celso Furtado, apreendendo-se um verdadeiro programa de desenvolvimento social, enraizando ambos os autores, para obtermos uma feliz compreensão do País a partir da Amazônia indígena.
Comparison of qSOFA, MEDS, and APACHE II Scores in Early Identification of Sepsis for Patients with 28 days Mortality and ICU Admission: A cross-sectional Study
Authors: Ranjit PD Shiv , Elangovan Akilan , Ramakrishnan TV , Panneerselvam Tamilanbu , Jasmine J Janifer
Published: April 2024

Introduction: Sepsis is a life-threatening infection that results in organ dysfunction due to an increased pathogen load, necessitating urgent intervention. There is a gap in clinicians’ ability to identify septic patients at high-risk with poor outcomes, highlighting the need for validated predictive scores for early intervention, favourable outcomes, and prompt recovery. Aim: To validate the predictive capacity of the Sequential Organ Failure Assessment (qSOFA), Mortality in Emergency Department Sepsis (MEDS), and Acute Physiology and Chronic Health Evaluation (APACHE 2) scores in patients with 28- day mortality and in Intensive Care Unit (ICU) patients due to sepsis. Materials and Methods: This cross-sectional study was conducted on 150 septic patients at the Department of Emergency Medicine, Sri Ramachandra Institute of Higher Education and Research in Chennai, India, between June and December 2022. Parameters assessed included Respiratory Rate (RR), Systolic Blood Pressure (SBP), Mean Arterial Pressure (MAP), temperature, White Blood Cell (WBC) count, platelet count, bilirubin, and creatinine. Descriptive analysis of age, gender, source, RR, GCS, SBP, qSOFA, MEDS, APACHE 2 in 28-day mortality, and ICU patients. Positive correlation and good predictivity of predictive scores (qSOFA, MEDS, APACHE 2) were analysed using Spearman’s Rank Correlation Coefficient (SRCCRs) statistical test in 28-day mortality and ICU patients. Results: A total of 150 septic patients (male: female-93:57) with an average age of 57.07±14.4 years were included. Urosepsis was the most common (n=51), followed by respiratory sepsis (n=48). Of these, 96 patients were admitted to the ICU, and 54 patients experienced 28-day mortality. The average and median values of RR were 27.1±7.64 breaths/minute (b/m) and 26 b/m, respectively. SBP values were 106.13±30.47 mmHg and 110 mmHg, respectively. Diastolic Blood Pressure (DBP) values were 66±16.51 mmHg and 60 mmHg, respectively. The average and median values of GCS were 12.75±3.92 and 15, respectively. The average for qSOFA was 29.1±0.025, with a median of 28; for MEDS, the average was 7.99±5.89, with a median of 7; and for APACHE 2, the average was 16.74±9.64, with a median of 15. Spearman’s Rank Correlation Coefficient (SRCCRs) demonstrated a strong positive correlation and good predictive validity between qSOFA, MEDS, and APACHE 2 scores in 28- day mortality and ICU patients (<0.001). Receiver Operating Characteristic Curve (ROC) analysis indicated good predictive validity for qSOFA in 28-day mortality and ICU patients. Conclusion: qSOFA exhibited a positive correlation and good predictive validity compared to MEDS and APACHE 2 in both 28-day mortality and ICU patients (<0.001). This study highlights the utility and applicability of qSOFA at the bedside for initial triage, as it can be quickly employed with minimal information.
Physiological Processes Affecting Postharvest Quality of Fresh Fruits and Vegetables
Authors: Umeohia Uchenna Emmanuel , Olapade Abiodun Adekunle
Published: April 2024

Fresh fruits and vegetables are integral components of a balanced diet, providing essential nutrients and contributing to human health. However, the postharvest quality of these perishable commodities is greatly influenced by various physiological processes that occur after harvest. This article reviews the key physiological processes affecting postharvest quality, including respiration, transpiration, ripening, senescence, and enzymatic activity. Understanding these processes is crucial for optimizing postharvest handling practices to extend shelf life, maintain quality attributes such as texture, flavor, color, and nutritional content, and minimize losses. Strategies to manage these physiological processes, including temperature and humidity control, modified atmosphere packaging, and the use of postharvest treatments, are discussed. Additionally, emerging technologies and innovative approaches for enhancing postharvest quality and extending the storage life of fresh fruits and vegetables are highlighted. By elucidating the complex interplay of physiological factors influencing postharvest quality, this review aims to provide valuable insights for researchers, practitioners, and stakeholders involved in the fresh produce supply chain, ultimately contributing to the promotion of food security and sustainability.
The Influence of Information Communication Technology on Financial Management
Authors: Michael N Emedo
Published: April 2024

Problem Statement: The major drawbacks attached to using olden methods of operation for financial management have been a major catalyst to the adoption of the fast growing Information Communication Technology in Financial Management. The major benefits and advantages of using this method are inestimable. Thus, there is need for presenting up-to-date information in this domain.

Aim: This paper presents up-to-date reference about Information Communication Technology influence on financial management.

Scope of Study: Basic fundamental information is also presented. The concepts of Information Communication Technology and Financial Management were explained. The components, elements and categories of Information Communication Technology in Financial Management were explained. Stock markets and banking sector were referenced as typical financial institutions using Information Communication Technology.

Conclusion: However, some drawbacks of utilizing Information Communication Technology in Financial Management were noticed in the course of investigation and were presented in the paper.  

Limitations: Future studies should look into the application of machine learning (such as artificial intelligence, robotics, automation and so on) to improve the influence of information communication technology on financial management. Further studies should be conducted on the applications of information communication technology in different financial management organizations to observe the variations in the ICT influence.
Unraveling the Impact of Geographical Indication on Consumer Preferences for Handloom Products
Authors: Singh Pushpam , Baral Sukanta Kumar
Published: April 2024

Handloom products represent an emotional significance in addition to their utilitarian function. It reminds us of the artistic skills and cultural uniqueness that exist in our nation. GI registrations have been granted to the handloom segment to protect the artists and maintain the authenticity of weaving. Due to a lack of knowledge about GI tag handloom products, consumers often face a dilemma when deciding whether or not to buy handloom products when other power-loomed fabrics are available. This study addresses the research gap by examining the factors contributing to consumers' willingness to buy Champa’s silk handloom products with GI tags. People generally associate the Champa region with the production of kosha silk. This study has brought in the Theory of Planned Behavior (TPB) as a base to develop a theoretical model for determining the intention to buy handloom products with GI tags. Using a convenient sampling approach, the researchers targeted potential handloom consumers as a demographic concern. A total of 250 questionnaires were distributed; out of those, 197 were deemed suitable for further study. The Theory of Planned Behavior (TPB) evaluates the behavioral characteristics of consumers while making purchases. The models were evaluated using the SmartPLS4 software. The findings showed that price veracity and consumer trust have a considerable positive impact on attitude. The handloom products with GI tags build potential trust among consumers on handloom products. Handloom store retailers should take the initiative to make consumers aware of the authenticity of their products, which prominently include GI certification labels on handloom items.
An Analysis of the Socioeconomic Benefits Arising from Kubwa Rail Station in Abuja, Nigeria
Authors: Emmanuel A. Komolafe , Victoria Bello A.
Published: April 2024

The study examined socioeconomic benefits arising from the location of the rail station in Kubwa community, Abuja. The study adopted survey research, and data was collected from household heads of rented multi-tenanted apartments in Kubwa within 3km of Kubwa rail station. Structured questionnaires were used to elicit data from a sample of household heads of rented multi-tenanted apartments in Kubwa. The collected data was analysed using a weighted mean score and the Kruktal-Wallis test. In a weighted mean, factors are ranked from 1st to last position in descending order of their weighted means, such that the factor with the highest weighted mean ranks first while the one with the lowest weighted mean ranks last. This method is used for its simplicity and ease of communicating the results of the research. The study found that within a one-kilometre radius of the rail station, increased property value is the highest socioeconomic benefit derived from the rail station. Following this came cost-effectiveness, increased retail activity, and improved accessibility and connectivity. The research also revealed that increased property value is the most significant benefit within a two-kilometre radius, followed by improved accessibility, connectivity, and cost-effectiveness. Also, within a three-kilometre radius, cost-effectiveness is the highest socioeconomic benefit derived from the rail station, followed closely by improved accessibility and connectivity, and time schedule and organization. Rail stations play a crucial role in urban and regional development that extends beyond mere accessibility by catalysing a variety of socioeconomic effects in the areas they serve. Consequently, the government must place a high priority on the meticulous maintenance and upkeep of the rail infrastructure.
Conservative Treatment of Acute Cholecystitis: An Updated Narrative Review
Authors: Rajah Kumar Hari
Published: April 2024

Conservative treatment of acute cholecystitis has been the initial treatment for acute cholecystitis, which involves the use of antibiotics to control the infection and prepare the patient for cholecystectomy. The Tokyo Guidelines have categorized patients who present with acute cholecystitis into three categories: Categories one, two and three. Although laparoscopic cholecystectomy is the gold standard of treatment, antibiotics and percutaneous cholecystostomy play a role in the management of patients with category two and three. This review aimes to examine the role of antibiotics and percutaneous cholecystostomy in the management of acute cholecystitis.
Bacteriological Evaluation of Surface and Groundwater used for Domestic Purposes in Ibadan
Authors: Abigail Ajongbolo Olayinka , Adediran K.O. , Adebambo Morakinyo Abraham , Abeo Abass Falilat , Gambo Ezekiel Dauda , Ntasin Paul Yiran , Ibrahim Adamu Muhammad
Published: April 2024

The right to safe and clean drinking water is a human right, unfortunately many communities rely on unsafe and contaminated water for drinking and domestic purposes. Through improper sewage and hospital waste disposal, pathogenic and antibiotic resistant bacteria have found their way to natural water sources used by humans. In this study we aim to profile pathogenic bacteria and resistant Escherichia coli (E. coli) from surface and ground water sources in three local government areas of Oyo state. 30 water samples were collected randomly from the selected local government areas. Bacteriological, biochemical and antibiotic-resistant analysis was carried out on the isolated bacteria from the water samples. E. coli (28.30%) and Kleb pneumoniae (23.77%) were the predominant bacteria isolates, while Shigella (16.22%) and Salmonella (16.22%) also had substantial percentages. Nineteen E. coli was isolated and identified, with high antibiotic resistance rates observed in nalidixic Acid (100%), augmentin (100%), ampiclox (94.74%) and third-generation cephalosporins. Conversely, moderate levels of resistance were observed in nitrofurantoin (55.55%), cefepime (57.89%), and second-generation fluoroquinolones. This study reveals substantial pathogenic bacteria and antibiotic resistant E. coli in water samples which endangers the health of communities’ dependent on these water sources and exposes the inhabitants to antibiotic-resistant organisms from contaminated water used for domestic purposes. It is crucial to put in place water treatment measures and quality monitoring programmes in order to guarantee that the populace has access to clean and safe drinking water.
Study of Physiological Growth Indices and Yield of Chickpea (Cicer arietinum L.) to Soil and Foliar Application Through Integrated Nutrient Management Practices
Authors: Abisankar M Sri , Augustine R . , Manuel R Isaac , Balaganesh B . , Kumar Dinesh
Published: April 2024

An investigation was conducted in Rabi season of 2023-24 at the instructional farm of Karunya Institute of Technology and Sciences, Coimbatore, to evaluate the performance of physiological indices on chickpeas under soil and foliar application. The experiment was established on a Factorial Randomized Block Design (FRBD). The treatments were soil application of NPK 100 percent (A1), NPK 100 percent + FYM 10 t ha-1 (A2), NPK 100 percent + Vermicompost 5 t ha-1 (A3), NPK 75 percent + FYM 10 t ha-1 (A4) and NPK 75 percent + Vermicompost 5 t ha-1 (A5) combined with foliar applications, viz., Nano-DAP (B1) and Nano-Urea (B2). The results of the study revealed that morpho-physiological attributes of chickpeas were statistically increased by the application of soil (NPK 75 percent + Vermicompost 5 t ha-1) combined with foliar (Nano-urea) nutrient management practices resulting in maximum grain yield of 15.64 q ha-1 and stover yield of 30.49 q ha-1. The results of this study underscore the importance of integrated nutrient management practices involving soil and foliar applications in enhancing the physiological indices of chickpeas.
Estimate of Genotypic and Phenotypic Correlation and Path Coefficient in Brinjal (Solanum melongena L)
Authors: Singh Nitesh Kumar , Yadav G.C. , Singh Dharmendra Bahadur , Tiwari Anuj , Prashant .
Published: April 2024

The significant positive correlation among phenotypic and genotypic performance, as well as path correlation of crops, contributes to the selection of superior cultivars. Based on the essential relevance of these estimations, it was used in our research. The current research was carried out during autumn winter season 2021-2022 with the aim of to estimate correlation coefficient among the growth and yield attribute and to elucidate the direct and indirect effects of different traits on yield through path coefficient analysis. The experimental material for the study consisted of 40 genotypes including one check (KS-224), laid in Randomized Complete Block Design with three replications. Observations were recorded on twelve quantitative characters. The most important trait, total fruit yield per plant had exhibited highly significant and positive phenotypic correlation with average fruit weight (0.662), number of fruits per plant (0.476), fruit circumference (0.394) and fruit polar length (0.392). Average fruit weight, number of fruits per plant, fruit circumference and fruit polar length were found significantly and positively correlated among themselves. The genotypic direct and indirect effects of most of the traits were similar in nature and higher in magnitude than the phenotypic direct and indirect effect. The higher magnitude of positive direct effect on total fruit yield was exerted by average fruit weight (0.793), number of fruits per plant (0.684) and fruit circumference (0.046). While, negative direct effect on total fruit yield per plant was exerted by days to 50 per cent flowering (-0.093), calyx length (-0.052) and pedicel length (-0.022). Thus, it can be inferred from the data above that selecting for these qualities will effectively enhance the crop for increased production and contributing traits.
Business Development Strategy for Rolling Bearing Product and Related Services in Food and Beverage Industry
Authors: Santoso R. Yulianto Hidayat , Lim Resmana
Published: April 2024

In running the business, every company has objective to grow and develop. Each company has different objective anddevelopment strategy, but identical in final goal, that is to gain profitable growth. Correct strategy is mandatory in developing business, where each company has its own unique character in term of product and penetrated market. Therefore, proper analysis is required in order to determine the correct business development strategy. Starts from market & customer intelligence, to decide whether the targeted market is potential or not. Continue with competitive position analysis, to evaluate whether the company is competitive or not and define what is needed to improve competitiveness in the market. Bearing X as one of market leader in bearing industry and related service, is developing their business to F&B sector. Writer is assigned as sector manager in the respective sector. Writer is doing market potential and competitive position analysis, to be reference in developing proper strategy development, based on Ansoff Matrix market and product development. Defined strategy also closely related with Bearing X’s Unique Selling Preposition (USP) as well as Total Cost of Ownership (TCO) which is proposed to each customer in F&B sector. Using Fishbone Diagram, Bearing X defines business development strategy and put it in to a roadmap, also plans the required investment in order to achieve the target of this business development.
Detail Engineering Design (DED) Pengembangan SPAM Kecamatan Karangbinangun Kabupaten Lamongan
Authors: Yuliani  , Octavia Tanti
Published: April 2024

Kebutuhan air bersih di Kecamatan Karangbinangun, Kabupaten Lamongan semakin meningkat sejalan dengan pertumbuhan penduduk serta berkembangnya kawasan pemukiman maupun industri. Dalam rangka pemenuhan kebutuhan air bersih dan kesehatan masyarakat serta pencapaian target nasional 10 juta sambungan rumah, direncanakan pengembangan SPAM di Kecamatan Karangbinangun Kabupaten Lamongan. Pengembangan SPAM direncanakan berkapasitas 300 liter/detik untuk melayani 4 kecamatan yakni Karangbinangun, Deket, Glagah, dan Kalitengah. Lingkup kegiatan DED adalah perencanaan intake, Instalasi Pengolahan Air (IPA), Desain pipa transmisi dan distribusi, Reservoir utama dan distribusi. Sistem intake direncanakan Sistem Intake Condoit. Pipa transmisi menggunakan pipa HDPE diameter 500 mm sepanjang ± 100 m. IPA direncanakan IPA paket sebanyak 3 unit, kapasitas masing-masing 100 liter/detik. Volume reservoir utama sebesar 5.000 m3sebanyak 1 unit dan reservoir di Kecamatan Deket sebesar 2.000 m3. Panjang pipa JDU sepanjang ±14.600 m.
EVALUASI PERENCANAAN SISTEM KELISTRIKAN RUMAH SAKIT “X” BERDASARKAN PUIL 2011 DAN APLIKASI ECODIAL
Authors: Kantonno Edbert Ryan , Setiadji Julius Sentosa , Hosea Emmy
Published: April 2024

Pembangunan Rumah Sakit “X” membutuhkan evaluasi untuk rancangan sistem kelistrikan yang akan dipasang pada rumah sakit tersebut. Instalasi listrik yang akan dipasang meliputi bangunan rumah sakit 2 lantai dan sebuah gedung pendukung yang terpisah dari gedung utama. Untuk instalasi listrik yang akan dievaluasi memiliki total beban ± 200 kVA yang bersumber dari PLN 197 kVA dan genset dengan kapasitas 200 kVA. Evaluasi untuk pemilihan komponen kelistrikan dilakukan dengan menggunakan bantuan 2 sarana yaitu dengan Persyaratan Umum Instalasi Listrik (PUIL 2011) dan aplikasi Ecodial dari Schneider Electric. Sedangkan untuk evaluasi pemilihan penangkal petir mengacu pada ketentuan pada SNI 03-7015-2004 tentang Sistem Proteksi Petir pada Bangunan Gedung. Dari hasil analisa menggunakan aplikasi Ecodial, ditemukan beberapa perbedaan dalam pemilihan komponen listrik. Dari hasil perbandingan antara gambar tender dan hasil perhitungan berdasarkan PUIL 2011 didapatkan beberapa perbedaan dalam pemilihan komponen yang meliputi pemilihan circuit breaker, kabel, dan busbar. Dari analisa pemilihan transformator dan genset didapatkan bahwa kapasitas pada rancangan tidak mencukupi kebutuhan. Untuk analisa grouping beban listrik ditemukan beberapa ketidaksesuaian seperti adanya grouping yang memiliki lebih dari 20 titik beban listrik. Dari evaluasi pemilihan penangkal petir, ternyata pemilihan penangkal petir pada rancangan telah sesuai dengan ketentuan yang berlaku.
PERENCANAAN SISTEM KOMPOR LISTRIK UNTUK PRODUKSI BATIK
Authors: Bhramantyo Ken Shaday Arya , Tumbelaka Hanny Hosiana , Tulistyantoro Lintu
Published: April 2024

Penelitian ini bertujuan untuk menganalisis penggunaan sistem kompor listrik, khususnya kompor induksi, dalam produksi batik sebagai alternatif yang efisien dan ramah lingkungan. Pembatik saat ini masih menggunakan kompor yang menggunakan minyak tanah, yang tidaklah ramah lingkungan. Dalam penelitian ini, kami menganalisis konsumsi energi listrik dan kualitas daya listrik yang dihasilkan oleh kompor listrik induksi, serta membandingkannya dengan kompor elemen pemanas. Tujuan kami adalah menjadikan kompor induksi sebagai peralatan pendukung alternatif dalam produksi batik di Indonesia, tetapi tetap mempertahankan ciri khas batik yang menggunakan peralatan tradisional seperti canting kayu, lilin/malam, dan wajan. Hasil penelitian menunjukkan bahwa kompor induksi lebih efisien dan hemat biaya dalam konsumsi listrik dibandingkan dengan kompor elemen pemanas. Penelitian ini berpotensi memberikan kontribusi dalam memperkenalkan teknologi yang lebih ramah lingkungan dan berkelanjutan dalam industri batik di Indonesia.
PERANCANGAN AIR MANCUR OTOMATIS SESUAI TEMPO MUSIK DI URBAN FARMING ALAM SARI PETRA
Authors: Clifford Ezechiel , Lim Resmana , Khoswanto Handry
Published: April 2024

Alam Sari Petra merupakan sarana Urban Farming PPPK (Perhimpunan Pendidikan dan Pengajaran Kristen Petra) Petra yang memiliki tujuan untuk membangun kesadaran para siswa terhadap wawasan lingkungan. Untuk menambah keelokan dari Urban Farming Alam Sari Petra, maka dirancangnya air mancur menari yang dapat menari sesuai tempo musik. Air mancur menari dirancang untuk dapat dikontrol ketinggian pancuran dan bergerak ke kanan kiri sesuai dengan keras suara dan frekuensinya. Hardware yang digunakan adalah Arduino Uno dengan memanfaatkan library ArduinoFFT untuk menentukan ketinggian pancuran dan fungsi AnalogRead untuk menentukan ketinggian pancuran dan gerakan aktuator. Alat diprogram menggunakan software Arduino IDE dengan memanfaatkan pulse timer menggunakan delay dan millis untuk mengatur tinggi pancuran dan gerakan aktuator ke kanan dan kiri. Hasil dari perancangan ini adalah air mancur dapat menari sesuai keras suara dan frekuensi suara yang didapat dari sumber audio berupa Handphone ataupun Laptop. Pengujian dilakukan dengan menghitung berapa waktu yang dibutuhkan untuk membuka valve atau menggerakkan aktuator untuk mencapai suatu ketinggian pancuran dan kemiringan aktuator yang diinginkan. Berdasarkan pengujian pada kolam kanan dan kiri, didapati gerakan aktuator membutuhkan 7 detik untuk mencapai kemiringan maksimum yaitu dengan sudut dalam 65° sedangkan 3 Way Valve perlu 16 detik untuk mencapai ketinggian maksimum yaitu 155 cm.
SISTEM KONTROL KESEIMBANGAN ROBOT BERODA SATU
Authors: Junian Hans , Thiang Thiang
Published: April 2024

Makalah ini menjelaskan tentang self balancing robot dimana robot tersebut hanya mempunyai satu roda. Robot beroda satu ini dapat menyeimbangkan dirinya sendiri. Dalam prototipe ini, robot yang dibuat dalam bentuk miniatur. Hardware robot ini terdiri atas baterai Lipo 3S 1500Mah, regulator lm 2596, sensor IMU MPU 6050, kontroler Arduino Uno, driver L298N untuk menggerakkan motor DC. Metode kontrol yang digunakan untuk menyeimbangkan robot adalah kontroler PID. Sensor accelerometer dan gyroscope yang terdapat dalam IMU digunakan untuk membaca posisi dan kemiringan robot yang kemudian dikirimkan ke kontroler arduino melalui komunikasi serial I2C. Pengujian sistem telah dilakukan dengan mencari nilai kombinasi PID yang terbaik, initial position maksimal yang dapat ditempuh oleh robot, serta sudut kemiringan maksimal yang dapat ditempuh oleh robot. Nilai kombinasi PID yang baik adalah Kp sebesar 30, Ki sebesar 200 dan Kd sebesar 1. Sedangkan untuk initial position maksimal yang dapat ditempuh oleh robot berada di range 175° hingga 185°. Dan untuk sudut kemiringan maksimal yang dapat ditempuh robot adalah sebesar 5°. Secara umum, sistem yang telah dibuat berhasil untuk menyeimbangkan robot berroda satu.
Persistent arthritis in Borrelia burgdorferi–infected HLA–DR4–positive CD28‐negative mice post–antibiotic treatment
Authors: Iliopoulou Bettina Panagiota , Alroy Joseph , Huber Brigitte T.
Published: November 2008

Objective

The immunologic events that lead to persistent joint inflammation in certain patients with Lyme arthritis post–antibiotic treatment have been elusive so far. The prevalence of this condition is highest in individuals with rheumatoid arthritis–associated HLA–DR alleles. This study was undertaken to generate a murine model with persistent arthritis post–antibiotic treatment.

Methods

We have previously shown that CD28−/− mice develop intermittent monarticular Lyme arthritis that is responsive to antibiotics. Since there seems to be a link in humans between persistent arthritic manifestations post–antibiotic treatment and the HLA–DR4 allele, we generated DR4+/+CD28−/−MHCII−/− mice, infected them with Borrelia burgdorferi, and subsequently treated them with antibiotics.

Results

Thirty‐eight percent of the B burgdorferi–infected DR4+/+CD28−/−MHCII−/− mice, but none of the B burgdorferi–infected CD28−/−MHCII−/− mice, remained arthritic post–antibiotic treatment. A significant fraction (36%) of these mice, but none of the mice in which arthritis resolved, had serum antibodies to outer surface protein A of B burgdorferi. After abrogation of active B burgdorferi infection, the inflammatory reaction in mice with persistent joint inflammation was restricted to the joints, since their draining lymph nodes were no longer enlarged. Increased CD20 and interferon‐γ messenger RNA expression in the inflamed joints of these mice suggested a possible role of B cells and inflammatory cytokines in the pathogenesis of persistent arthritis post–antibiotic treatment.

Conclusion

The establishment of this murine model allows, for the first time, the elucidation of the immunologic events that lead to persistent Lyme arthritis post–antibiotic therapy in genetically susceptible individuals.
Autoantibodies and microvascular damage are independent predictive factors for the progression of Raynaud's phenomenon to systemic sclerosis: A twenty‐year prospective study of 586 patients, with validation of proposed criteria for early systemic sclerosis
Authors: Koenig Martial , Joyal France , Fritzler Marvin J. , Roussin André , Abrahamowicz Michal , Boire Gilles , Goulet Jean‐Richard , Rich Éric , Grodzicky Tamara , Raymond Yves , Senécal Jean‐Luc
Published: November 2008

Objective

To identify in patients with Raynaud's phenomenon (RP) independent markers that predict progression to definite systemic sclerosis (SSc) and to determine in patients with progression to SSc the type and sequence of microvascular damage and its relationship to SSc‐specific autoantibodies.

Methods

Consecutive patients referred for evaluation of RP who had no definite connective tissue disease were evaluated for microvascular damage by nailfold capillary microscopy (NCM) and for anticentromere (anti–CENP‐B), anti‐Th/To, anti–topoisomerase I, and anti–RNA polymerase III (anti–RNAP III) autoantibodies by specific assays. Patients were studied prospectively.

Results

Of the 586 patients who were followed up for 3,197 person‐years, 74 (12.6%) developed definite SSc. A characteristic sequence of microvascular damage was identified, starting with enlarged capillaries, followed by capillary loss, and then by capillary telangiectases. Definite SSc was diagnosed in close temporal relationship to capillary loss. Enlarged capillaries, capillary loss, and SSc‐specific autoantibodies independently predicted definite SSc. Anti–CENP‐B and anti‐Th/To antibodies predicted enlarged capillaries; these autoantibodies and anti–RNAP III predicted capillary loss. Each autoantibody was associated with a distinct time course of microvascular damage. At followup, 79.5% of patients with 1 of these autoantibodies and abnormal findings on NCM at baseline had developed definite SSc. Patients with both baseline predictors were 60 times more likely to develop definite SSc. The data validated the proposed criteria for early SSc.

Conclusion

In RP evolving to definite SSc, microvascular damage is dynamic and sequential, while SSc‐specific autoantibodies are associated with the course and type of capillary abnormalities. Abnormal findings on NCM at baseline together with an SSc‐specific autoantibody indicate a very high probability of developing definite SSc, whereas their absence rules out this outcome.
Small molecule inhibitors of Hsp90 potently affect inflammatory disease pathways and exhibit activity in models of rheumatoid arthritis
Authors: Rice John W. , Veal James M. , Fadden R. Patrick , Barabasz Amy F. , Partridge Jeffrey M. , Barta Thomas E. , Dubois Laura G. , Huang Kenneth H. , Mabbett Sarah R. , Silinski Melanie A. , Steed Paul M. , Hall Steven E.
Published: November 2008

Objective

To evaluate the ability of SNX‐7081, a novel small molecule inhibitor of Hsp90, to block components of inflammation, including cytokine production, protein kinase activity, and angiogenic signaling. A close analog was evaluated in preclinical in vivo models of rheumatoid arthritis (RA).

Methods

SNX‐7081 binding to Hsp90 was characterized in Jurkat cells and RA synovial fibroblasts (RASFs). Inhibition of NF‐κB nuclear translocation was evaluated in cellular systems, using lipopolysaccharide (LPS), tumor necrosis factor α, or interleukin‐1β stimulation. Suppression of cytokine production in THP‐1 cells, human umbilical vein endothelial cells, and RASFs was studied. Disruption of MAPK signaling cascades by SNX‐7081 following growth factor stimulation was assessed. SNX‐7081 was tested in 2 relevant angiogenesis assays: platelet‐derived growth factor activation of fibroblasts and LPS‐induced nitric oxide (NO) release in J774 macrophages. A close analog, SNX‐4414, was evaluated in rat collagen‐induced arthritis and adjuvant‐induced arthritis, following oral treatment.

Results

SNX‐7081 showed strong binding affinity to Hsp90 and expected induction of Hsp70. NF‐κB nuclear translocation was blocked by SNX‐7081 at nanomolar concentrations, and cytokine production was potently inhibited. Growth factor activation of ERK and JNK signaling was significantly reduced by SNX‐7081. NO production was also sharply inhibited. In animal models, SNX‐4414 fully inhibited paw swelling and improved body weight. Scores for inflammation, pannus formation, cartilage damage, and bone resorption returned to normal.

Conclusion

The present results demonstrate that a small molecule Hsp90 inhibitor can impact inflammatory disease processes. The strong in vivo efficacy observed with SNX‐4414 provides preclinical validation for consideration of Hsp90 inhibitors in the treatment of RA.
Splenic suppressor of cytokine signaling 3 transgene expression affects T cell responses and prevents development of collagen‐induced arthritis
Authors: Veenbergen Sharon , Bennink Miranda B. , de Hooge Alfons S. K. , Arntz Onno J. , Smeets Ruben L. , van den Berg Wim B. , van de Loo Fons A. J.
Published: November 2008

Objective

Members of the suppressor of cytokine signaling (SOCS) family are key negative intracellular regulators of cytokine and growth factor responses, including those that regulate immune responses in autoimmune disorders, such as rheumatoid arthritis (RA). The aim of this study was to investigate modulation of T cell immunity for the treatment of experimental arthritis, via enhanced expression of SOCS‐3 in splenic antigen‐presenting cells (APCs) obtained after intravenous injection of adenovirus encoding SOCS‐3.

Methods

DBA/1 mice were immunized with type II collagen, and adenovirus vectors were administered by intravenous injection before the clinical onset of collagen‐induced arthritis (CIA). Splenic cellular responses were analyzed by measuring cytokine production, using Luminex multi‐analyte technology. Th cell populations were analyzed by flow cytometry.

Results

Systemic delivery of adenovirus encoding SOCS‐3 resulted in enhanced transgene expression in splenic APCs, which led to decreased production of interleukin‐23 (IL‐23), IL‐6, and tumor necrosis factor α, but significantly higher production of antiinflammatory IL‐10, by these cells. Fluorescence‐activated cell sorting analysis showed increased numbers of splenic CD4+ T cells after SOCS‐3 treatment. In the presence of SOCS‐3–transduced APCs, however, purified splenic CD3+ T cells showed reduced antigen‐specific proliferation and a significant reduction in the production of interferon‐γ (−43%), IL‐4 (−41%), and IL‐17 (−70%). Interestingly, the altered splenic cellular responses were accompanied by a protective effect on CIA development, and histologic analysis of knee joints showed reduced joint inflammation and connective tissue destruction.

Conclusion

This study demonstrates effective prevention of CIA after intravenously induced overexpression of SOCS‐3; this is probably caused by the generation of tolerogenic APCs, which have an inhibitory effect on Th1, Th2, and especially, Th17 cell activity.
Promotion of the local differentiation of murine Th17 cells by synovial macrophages during acute inflammatory arthritis
Authors: Egan Paul J. , van Nieuwenhuijze Annemarie , Campbell Ian K. , Wicks Ian P.
Published: November 2008

Objective

To examine the generation of proinflammatory Th17 cells at the site of tissue inflammation and in draining lymph nodes using an interleukin‐17 (IL‐17)–dependent model of acute inflammatory arthritis.

Methods

Arthritis was elicited in mice by intraarticular injection of methylated bovine serum albumin (mBSA) into the knee and subcutaneous injection of IL‐1β. Anti–IL‐17 or control antibodies were administered during arthritis induction. Cytokine expression was evaluated by intracellular cytokine staining of synovial lymphocytes, by polymerase chain reaction analysis of RNA extracted from lymph node cells, and by enzyme‐linked immunosorbent assay of cell culture supernatants. Th17 differentiation of naive CD4+ T cells was assessed in cocultures with macrophages from arthritic mice.

Results

Anti–IL‐17 antibody administered during acute arthritis markedly reduced disease, indicating that the model is IL‐17 dependent. IL‐17 messenger RNA (mRNA), but not protein, was detected in draining lymph node CD4+ T cells and preceded joint inflammation. In addition, mRNA for Th17 cell–stimulatory cytokines (transforming growth factor β, IL‐6) and Th17 cell–inhibitory cytokines (interferon‐γ, IL‐4) was detected in lymph nodes following injection of mBSA and IL‐1β. Th17 cells were clearly identified in the inflamed synovium at the peak of disease. Synovial macrophages supported Th17 cell generation from naive CD4+ T cell precursors stimulated via CD3 in vitro and produced high levels of IL‐6. In contrast, peritoneal macrophages failed to induce Th17 cell differentiation and produced less IL‐6.

Conclusion

These results suggest that Th17 cell differentiation is initiated in draining lymph nodes but that IL‐17–producing cells are restricted to the inflamed synovium, being generated in response to local cytokines produced by inflammatory macrophages.
The influence of sex on the chondrogenic potential of muscle‐derived stem cells: Implications for cartilage regeneration and repair
Authors: Matsumoto Tomoyuki , Kubo Seiji , Meszaros Laura B. , Corsi Karin A. , Cooper Gregory M. , Li Guangheng , Usas Arvydas , Osawa Aki , Fu Freddie H. , Huard Johnny
Published: November 2008

Objective

To explore possible differences in muscle‐derived stem cell (MDSC) chondrogenic differentiation in vitro and articular cartilage regeneration in vivo between murine male MDSCs (M‐MDSCs) and female MDSCs (F‐MDSCs).

Methods

Three different populations of M‐ and F‐MDSCs (n = 3 of each sex) obtained via preplate technique, which separates cells based on their variable adhesion characteristics, were compared for their in vitro chondrogenic potential using pellet culture. Cells were assayed with and without retroviral transduction to express bone morphogenetic protein 4 (BMP‐4). The influence of both expression of stem cell marker Sca1 and in vitro expansion on the chondrogenic potential of M‐ and F‐MDSCs was also determined. Additionally, BMP‐4–transduced M‐ and F‐MDSCs were applied to a full‐thickness articular cartilage defect (n = 5 each) on the femur of a nude rat, and the quality of the repaired tissue was evaluated by macroscopic and histologic examination.

Results

With and without BMP‐4 gene transduction, M‐MDSCs produced significantly larger pellets with a richer extracellular matrix, compared with F‐MDSCs. Sca1 purification influenced the chondrogenic potential of MDSCs, especially M‐MDSCs. Long‐term culture did not affect the chondrogenic potential of M‐MDSCs but did influence F‐MDSCs. M‐MDSCs repaired articular cartilage defects more effectively than did F‐MDSCs at all time points tested, as assessed both macroscopically and histologically.

Conclusion

Our findings demonstrate that sex influences the chondrogenic differentiation and articular cartilage regeneration potential of MDSCs. Compared with female MDSCs, male MDSCs display more chondrogenic differentiation and better cartilage regeneration potential.