bluuebunny/crossref_metadata_2025 huggingface dataset:
Weakened Contractile Performance and Mitochondrial Respiratory Complex Activity in Skeletal Muscle Improve during Interbout Arousal in Hibernating Daurian Ground Squirrel, Spermophilus dauricus
Authors: Wang Huiping , Guo Yuxi , Yan Wenjing , Cao Liqi , Bai Xiaozhuo , Zhao Jing , Dang Kai , Gao Yunfang
Published: October 2023

Mammalian hibernation is composed of multiple episodes of torpor bout, separated by phases of interbout arousal. During torpor, the skeletal muscles of mammals are undoubtedly inactive, but it has been proven to mitigate disuse atrophy. While interbout arousal has been implicated in the prevention of muscle atrophy, the underlying mechanisms sustaining muscle contraction remain to be explored. In the present study, Daurian ground squirrels (Spermophilus dauricus) were divided into four groups: pre-hibernation (PRE), torpor (TOR), interbout arousal (IBA), and post-hibernation (POST). The contractile performance of slow-twitch soleus muscle (SOL) and fast-twitch extensor digitorum longus muscle (EDL) was detected both in situ and in vitro. Concurrently, mitochondrial respiratory chain complex activity in these muscles was quantified. Our findings revealed that in situ contractile properties of both muscles, including force, power output, time duration, and force development/relaxation rates of twitch contraction, and force and power output of tetanic contraction declined in the TOR group compared to the PRE group, but improved in the IBA and POST groups. Fatigue resistance of muscles, determined by the power output of repetitive tetanic contractions in situ, decreased in the TOR group but recovered in the IBA and POST groups. In vitro studies demonstrated that tetanic contraction power output in isolated muscles increased with muscle temperature in both TOR and IBA groups. However, at the same temperature, power output was consistently lower in the TOR group compared to the IBA group. Moreover, the activity of the mitochondrial respiratory chain complex, especially Complexes I and II, decreased in the TOR group but showed recovery in the IBA and POST groups. These findings suggest that both the contractile performance and fatigue resistance of mammalian skeletal muscle are compromised during torpor but can be improved during interbout arousal and post-hibernation. The rebound in body temperature and rise in mitochondrial respiratory chain complex activity in skeletal muscle are involved in enhancing contractile performance and fatigue resistance. This study suggests that interbout arousal functions as a vital temporal interval during which skeletal muscles can transition from the inactivity induced by torpor to a state of restored contractile functionality. Thus, interbout arousal serves as a behavioral safeguard against disuse-induced damage to skeletal muscles during hibernation.
Effect of Different Contents of 63s Bioglass on the Performance of Bioglass-PCL Composite Bone Scaffolds
Authors: Zhang Chen , Chen Shihao , Vigneshwaran Muniyandi , Qi Yi , Zhou Yulai , Fu Gaosheng , Li Zhiyu , Wang Jianlei
Published: October 2023

Bioactive glasses (BG), notably 63s BG, possess distinct properties such as biodegradability, biocompatibility, and the ability to boost cellular interactions. Our research concentrated on formulating polycaprolactone (PCL) porous scaffolds enriched with 63s BG to gauge their combined mechanical and biological potentials. Using twin-screw extrusion, we created composites containing 5%, 10%, and 20% 63s BG. These were transformed into cylindrical scaffolds using 3D printing. Our assessments involved melt flow, SEM, XRD, water contact angle metrics, DSC, and extracorporeal degradation. After co-culturing with MC3T3-E1 cells, an uptick in alkaline phosphatase activity was noted. Preliminary findings demonstrated that as 63s BG content increased, the properties of the composites improved. Yet, they fell short of replicating the mechanical nuances of cortical bone, rendering them inapt for load-bearing orthopedic applications but suitable for mending minor bone defects or cartilage. In summary, while 63s BG brings about significant advancements in scaffold attributes, attaining the mechanical traits ideal for certain medical purposes remains elusive. This investigation offers foundational insights for the evolution of optimized bone tissue engineering materials.
Rehabilitation Exercises Supported by Monitor-Augmented Reality for Patients with High-Grade Glioma Undergoing Radiotherapy: Results of a Randomized Clinical Trial
Authors: Pieczyńska Anna , Zasadzka Ewa , Pilarska Agnieszka , Procyk Danuta , Adamska Krystyna , Hojan Katarzyna
Published: October 2023

Background: Exercise has been shown to improve quality of life (QoL) and even treatment outcomes in cancer patients. However, the evidence to support the benefits of exercise in patients with high-grade glioma (HGG) is limited. Therefore, we performed a randomized clinical trial (RCT) to examine the effect of augmented-reality-based rehabilitation exercises on physical and functional fitness, cognitive function, fatigue, mood, QoL, selected blood parameters, brain derived neurotrophic factor (BDNF), and S100 protein in patients with HGG. Methods: Adult patients with HGG scheduled to undergo radiotherapy after tumor resection were randomized to participate in an exercise program (experimental group, n = 25) or to receive usual care (controls, n = 22). Physical and mental fitness was measured at baseline, after the completion of radiotherapy, and at 3 months. The following tests were administered: Handgrip Strength Test; 6-Minute Walk Test; Time Up and Go test; Functional Independent Measure scale; Addenbrooke’s Cognitive Examination III (ACE III); Hospital Anxiety and Depression Scale; Functional Cancer Therapy Assessment—Brain; and Functional Assessment of Chronic Illness Therapy—Fatigue. We also measured blood parameters, BDNF, and S100 protein levels. Results: No significant changes were observed in the exercise group. However, the controls experienced a significant decrease in HGS and in the ACE III attention domain. No significant changes were observed in QoL, fatigue, BDNF, or S100 levels in either group. Conclusions: Augmented-reality-based exercise during radiation therapy may prevent loss of muscle strength and attention in patients with HGG.
Face the Future—Artificial Intelligence in Oral and Maxillofacial Surgery
Authors: Miragall Maximilian F. , Knoedler Samuel , Kauke-Navarro Martin , Saadoun Rakan , Grabenhorst Alex , Grill Florian D. , Ritschl Lucas M. , Fichter Andreas M. , Safi Ali-Farid , Knoedler Leonard
Published: October 2023

Artificial intelligence (AI) has emerged as a versatile health-technology tool revolutionizing medical services through the implementation of predictive, preventative, individualized, and participatory approaches. AI encompasses different computational concepts such as machine learning, deep learning techniques, and neural networks. AI also presents a broad platform for improving preoperative planning, intraoperative workflow, and postoperative patient outcomes in the field of oral and maxillofacial surgery (OMFS). The purpose of this review is to present a comprehensive summary of the existing scientific knowledge. The authors thoroughly reviewed English-language PubMed/MEDLINE and Embase papers from their establishment to 1 December 2022. The search terms were (1) “OMFS” OR “oral and maxillofacial” OR “oral and maxillofacial surgery” OR “oral surgery” AND (2) “AI” OR “artificial intelligence”. The search format was tailored to each database’s syntax. To find pertinent material, each retrieved article and systematic review’s reference list was thoroughly examined. According to the literature, AI is already being used in certain areas of OMFS, such as radiographic image quality improvement, diagnosis of cysts and tumors, and localization of cephalometric landmarks. Through additional research, it may be possible to provide practitioners in numerous disciplines with additional assistance to enhance preoperative planning, intraoperative screening, and postoperative monitoring. Overall, AI carries promising potential to advance the field of OMFS and generate novel solution possibilities for persisting clinical challenges. Herein, this review provides a comprehensive summary of AI in OMFS and sheds light on future research efforts. Further, the advanced analysis of complex medical imaging data can support surgeons in preoperative assessments, virtual surgical simulations, and individualized treatment strategies. AI also assists surgeons during intraoperative decision-making by offering immediate feedback and guidance to enhance surgical accuracy and reduce complication rates, for instance by predicting the risk of bleeding.
Reply to Alt et al. Comment on “Lunz et al. Impact and Modification of the New PJI-TNM Classification for Periprosthetic Joint Infections. J. Clin. Med. 2023, 12, 1262”
Authors: Lunz Andre , Lehner Burkhard , Voss Moritz N. , Knappe Kevin , Jaeger Sebastian , Innmann Moritz M. , Renkawitz Tobias , Omlor Georg W.
Published: October 2023

We greatly appreciate the comments made by Alt et al. [...]
Mechanisms of Diabetic Nephropathy Not Mediated by Hyperglycemia
Authors: Viggiano Davide
Published: October 2023

Diabetes mellitus (DM) is characterized by the appearance of progressive kidney damage, which may progress to end-stage kidney disease. The control of hyperglycemia is usually not sufficient to halt this progression. The kidney damage is quantitatively and qualitatively different in the two forms of diabetes; the typical nodular fibrosis (Kimmelstiel Wilson nodules) appears mostly in type 1 DM, whereas glomerulomegaly is primarily present in type 2 obese DM. An analysis of the different metabolites and hormones in type 1 and type 2 DM and their differential pharmacological treatments might be helpful to advance the hypotheses on the different histopathological patterns of the kidneys and their responses to sodium/glucose transporter type 2 inhibitors (SGLT2i).
Clinical Characteristics of Anti-Synthetase Syndrome and Variables Associated with Interstitial Lung Disease and Mortality: A Retrospective Cohort Study
Authors: Sodsri Tulaton , Petnak Tananchai , Ngamjanyaporn Pintip
Published: October 2023

Anti-synthetase syndrome (ASS) is a rare autoimmune disease. Since the knowledge of ASS remains limited, we conducted the retrospective study aiming to describe clinical characteristics and identify variables associated with interstitial lung disease (ILD) and mortality among patients with ASS. Patients diagnosed with ASS from January 2013 to October 2022 were included. Patient demographics, clinical manifestations, myositis auto-antibody profiles, HRCT findings, and laboratory tests were collected. Variables associated with mortality risk and ILD were evaluated using the Cox proportional hazards model and the logistic regression model, respectively. A total of 82 patients with ASS were included. Clinical manifestations included arthritis (57%), Raynaud’s phenomenon (32%), mechanic’s hands (29%), fever (26%), and myositis (17%). The myositis auto-antibody profiles included anti-PL-7 (29%), anti-Jo-1 (27%), anti-EJ (17%), anti-PL-12 (16%), and anti-OJ (11%). ILD was observed in 64 patients (78%). Among patients with ILD, 21 initially presented with ILD before developing other ASS clinical manifestations, 29 simultaneously presented with ILD and other symptoms, and 14 had isolated ILD throughout follow-up. Overall, 6 patients presented with rapid-progressive ILD. With a median follow-up time of 2.5 years, mortality was observed in 10 patients (12.2%). Factors associated with mortality included increased lymphocyte counts (adjusted HR, 0.74; 95% CI, 0.61–0.91; p < 0.01), isolated ILD (adjusted HR, 9.59; 95% CI, 1.52–60.61; p = 0.02) and the presence of anti-Ro52 antibodies (adjusted HR, 0.14; 95% CI, 0.02–0.93; p = 0.04). Factors associated with ILD included age (adjusted OR, 1.10; 95% CI, 1.03–1.18; p = 0.01), presence of anti-Ro52 antibodies (adjusted OR, 17.92; 95% CI, 2.13–138.68; p = 0.01), and presence of arthritis (adjusted OR, 0.09; 95% CI, 0.01–0.75; p = 0.03). Our study demonstrated a favorable overall mortality rate among ASS patients.
Association between the Obstructive Sleep Apnea and Cephalometric Parameters in Teenagers
Authors: Manrikyan Gayane E. , Vardanyan Izabella F. , Markaryan Marina M. , Manrikyan Mikayel E. , Badeyan Elen H. , Manukyan Anna H. , Gevorgyan Mariana A. , Khachatryan Samson G.
Published: October 2023

Background: OSA is a common problem in children and adolescents. Angle class II malocclusion, a tendency toward the vertical type of growth, causes a decrease in the volume of the oral air space, increasing the risk of OSAS. The aim of this study was to evaluate the relationship between cephalometric and OSA parameters, to develop collaborative approaches between orthodontists and somnologists in the treatment of adolescents with OSA. Methods: We analyzed data from 41 adolescents with OSA. Their mean age was 15.8 ± 1.08 years. Orthodontic and polysomnographic examinations of patients were conducted. Statistical analysis was performed in SPSS 19.0.0. Results: Most often in patients with distal occlusion, a violation of the harmony in the development of the dental system was observed. The sagittal incisive fissure, characteristic of a distal occlusion, was absent due to the palatal inclination of the upper incisors in 25 (60.98%) patients. The SNB was 79.4 ± 3.1°, indicating a distal position of the mandible relative to the anterior cranial base. The SNA exceeded the normal value, which is one of the prerequisites for mandibular retrognathia. The ANB angle was 4.3 ± 1.9°. Tonsillar hypertrophy affected 6 patients, 21 had adenoid hypertrophy, and 3 had both of them. Movements of the masticatory muscles during sleep were recorded in 22.0% of patients. Conclusion: To improve the quality of diagnosis and treatment of OSA, a multidisciplinary approach is needed that will correct the processes of child growth and development.
Multifactorial Colonization of the Pregnant Woman’s Reproductive Tract: Implications for Early Postnatal Adaptation in Full-Term Newborns
Authors: Gibała Piotr , Jarosz-Lesz Anna , Sołtysiak-Gibała Zuzanna , Staniczek Jakub , Stojko Rafał
Published: October 2023

This retrospective study aimed to investigate the impact of microorganisms identified in the reproductive tract on disorders during the early adaptation period in newborns. A cohort of 823 patients and cervical canal cultures were analyzed to identify the presence of microorganisms. Newborns included in the study were divided into two groups due to the number of pathogens identified in the swab from the cervical canal of the mother. The first group consisted of newborns whose mothers had one pathogen identified (N = 637), while the second group consisted of newborns whose mothers had two or more pathogens identified (N = 186). The analysis of disorders of the early adaptation period included the incidence of respiratory distress syndrome, the number of procedures performed with the use of CPAP, oxygen therapy, antibiotic therapy and parenteral nutrition. Respiratory distress syndrome was more common in group II than in group I (85 vs. 31, p = 0.001). In group II, CPAP (63 vs. 21, p = 0.001), oxygen therapy (15 vs. 8, p = 0.02) and antibiotics were used more frequently (13 vs. 8, p = 0.01). The findings of this study revealed that the number of pathogens colonizing the reproductive tract had a significant influence on the early adaptation period in newborns. Multifactorial colonization of the reproductive tract was associated with an increased incidence of infections in newborns and a higher prevalence of acid–base balance disorders. This study highlights the importance of monitoring and addressing the microbial composition of the reproductive tract during pregnancy.
Impact of Endometrial Preparation on the Maternal and Fetal Cardiovascular Variables of the First Trimester Combined Screening Test
Authors: Dallagiovanna Chiara , Benaglia Laura , Reschini Marco , Di Gesaro Luca , Li Piani Letizia , Persico Nicola , Vigano’ Paola , Somigliana Edgardo
Published: October 2023

The modality of endometrial preparation for the transfer of frozen-thawed embryos may influence maternal and fetal adaptation to pregnancy and could thus impact the results of the first trimester combined screening test. We conducted a retrospective cross-sectional study on singleton pregnancies achieved by embryo transfer of a single frozen-thawed blastocyst, comparing two different endometrial preparation protocols: natural cycle (n = 174) and hormone replacement therapy (HRT) (n = 122). The primary outcome was the risk of preeclampsia at the first trimester combined screening test. Secondary endpoints included variable reflecting fetal cardiac function (nuchal translucency and fetal heart rate), maternal adaptation (median arterial blood pressure—MAP and uterine arteries pulsatility index—UtA-PI), and placentation (pregnancy associated plasma protein A and placental growth factor). The risk of early preeclampsia was comparable in the two groups (38% vs. a 28%, p = 0.12). However, women in the natural cycle group showed lower fetal heart rate (159 [155–164] vs. 164 [158–168], p = 0.002) and higher UtA-PI (0.96 [0.74–1.18] vs. 0.72 [0.58–0.90], p < 0.001). The frequency of a screening test at high risk for aneuploidies was similar. The modality of transfer of frozen-thawed embryos is associated with changes in the variables reflecting maternal and fetal cardiovascular function.
Clinical Factors for Predicting Pharmacotherapy in Twin Pregnancies Complicated by Gestational Diabetes Mellitus
Authors: Catic Anja , Reischer Theresa , Heinzl Florian , Göbl Christian , Yerlikaya-Schatten Gülen
Published: October 2023

Controlling blood glucose levels is the main target in pregnant women with gestational diabetes mellitus (GDM). Twin pregnancies are offered the same screening selection and have the same diagnostic criteria as well as treatment of gestational diabetes as singleton pregnancies, even though the risks for pregnancy complications are increased. The aim of this study was to assess the association between predicting factors, OGTT glucose levels and pharmacotherapy requirements in twin pregnancies with GDM. This retrospective cohort study included 446 GDM patients with twin pregnancies (246 managed with lifestyle modifications and 200 requiring pharmacotherapy) over a time period of 18 years. An evaluation of maternal characteristics and a standardized 75 g oral glucose test (OGGT) for glucose concentrations at fasting, 1 h and 2 h were conduced. OGTT glucose levels at fasting (=0 min, p < 0.01) and 1 h (p < 0.01) were significantly associated with the later requirement of pharmacotherapy. Also, clinical risk factors (pre-pregnancy BMI p < 0.01, multiparity p < 0.05, GDM in previous pregnancy p < 0.01, assisted reproduction p < 0.05) showed a predictive accuracy for insulin therapy in twin pregnancies complicated by GDM, whereas age and chorionicity had no effect. OGTT glucose measures in addition to clinical risk factors are promising variables for risk stratification in mothers with GDM and twin pregnancy.
Radiologic Progression of Interstitial Lung Abnormalities following Surgical Resection in Patients with Lung Cancer
Authors: Shin Yoon Joo , Yi Jeong Geun , Kim Mi Young , Son Donghee , Ahn Su Yeon
Published: October 2023

In this study, we aimed to assess the prevalence of interstitial lung abnormalities (ILAs) and investigate the rates and risk factors associated with radiologic ILA progression among patients with lung cancer following surgical resection. Patients who underwent surgical resection for lung cancer at our institution from January 2015 to December 2020 were retrospectively evaluated and grouped according to their ILA status as having no ILAs, equivocal ILAs, or ILAs. Progression was determined by simultaneously reviewing the baseline and corresponding follow-up computed tomography (CT) scans. Among 346 patients (median age: 67 (interquartile range: 60–74) years, 204 (59.0%) men), 22 (6.4%) had equivocal ILAs, and 33 (9.5%) had ILAs detected upon baseline CT. Notably, six patients (6/291; 2.1%) without ILAs upon baseline CT later developed ILAs, and 50% (11/22) of those with equivocal ILAs exhibited progression. Furthermore, 75.8% (25/33) of patients with ILAs upon baseline CT exhibited ILA progression (76.9% and 71.4% with fibrotic and non-fibrotic ILAs, respectively). Multivariate analysis revealed that ILA status was a significant risk factor for ILA progression. ILAs and equivocal ILAs were associated with radiologic ILA progression after surgical resection in patients with lung cancer. Hence, early ILA detection can significantly affect clinical outcomes.
Tick-Borne Encephalitis (TBE): From Tick to Pathology
Authors: Worku Dominic Adam
Published: October 2023

Tick-borne encephalitis (TBE) is a viral arthropod infection, endemic to large parts of Europe and Asia, and is characterised by neurological involvement, which can range from mild to severe, and in 33–60% of cases, it leads to a post-encephalitis syndrome and long-term morbidity. While TBE virus, now identified as Orthoflavivirus encephalitidis, was originally isolated in 1937, the pathogenesis of TBE is not fully appreciated with the mode of transmission (blood, tick, alimentary), viral strain, host immune response, and age, likely helping to shape the disease phenotype that we explore in this review. Importantly, the incidence of TBE is increasing, and due to global warming, its epidemiology is evolving, with new foci of transmission reported across Europe and in the UK. As such, a better understanding of the symptomatology, diagnostics, treatment, and prevention of TBE is required to inform healthcare professionals going forward, which this review addresses in detail. To this end, the need for robust national surveillance data and randomised control trial data regarding the use of various antivirals (e.g., Galidesivir and 7-deaza-2′-CMA), monoclonal antibodies, and glucocorticoids is required to improve the management and outcomes of TBE.
Thermal Imaging of Tongue Surface as a Prognostic Method in the Diagnosis of General Diseases—Preliminary Study
Authors: Wziątek-Kuczmik Daria , Niedzielska Iwona , Mrowiec Aleksandra , Stanek Agata , Gościniewicz Piotr , Mrukwa-Kominek Ewa , Cholewka Armand
Published: October 2023

The aim of this work was to develop an original method of thermographic measurement of tongue temperature as a prognostic method in the diagnosis of general diseases. This study examined the temperature distribution on the dorsal and apical surfaces of the tongue in patients with various general diseases and introduced a procedure for cooling the oral cavity. Patients with a high risk of systemic infections were referred to the Oral and Maxillofacial Surgery Outpatient Clinic of the Medical University of Silesia (SUM) in Katowice to identify potential foci of dental infections. They underwent an evaluation of their dentition as well as a prognostic tongue examination using the thermal camera FLIR T540 with a sensitivity of <0.03 K. The obtained results revealed statistically significant differences in the tongue average temperature parameters between the two study groups—healthy patients and patients with disorders. We obtained median temperatures for tongue dorsum (TD) of 35.8 °C and 35.2 °C for healthy patients and patients with disorders, respectively. Also, statistical differences have been obtained for tongue apex (TA) average temperatures. They were 35.5 °C and 34.0 °C for healthy and patients, respectively (p = 0.0001). Similar statistical results presented significant differences in the temperature difference (defined as DT = average temperature 10 min − average temperature 2 min after rinsing of the mouth) of the examined areas of the tongue between the healthy temperature and the unhealthy patient’s temperature. It seems that thermal imaging has potential in the prevention and diagnosis of general diseases.
p16 Overexpression in Sinonasal Squamous Cell Carcinoma: Association with Human Papillomavirus and Prediction of Survival Outcomes
Authors: Hirakawa Hitoshi , Ikegami Taro , Touyama Masatomo , Ooshiro Yurika , Higa Tomoyo , Higa Teruyuki , Agena Shinya , Kinjyo Hidetoshi , Kondo Shunsuke , Kise Norimoto , Tanaka Katsunori , Maeda Hiroyuki , Tamaki Tomoko , Wada Naoki , Suzuki Mikio
Published: October 2023

p16 overexpression is often used as a surrogate marker for human papillomavirus (HPV) infection in oropharyngeal squamous cell carcinoma but remains an uncertain diagnostic tool for HPV-related sinonasal squamous cell carcinoma (SNSCC). Our study involved 79 consecutive SNSCC patients who were treated at a tertiary referral university hospital during 2006–2021. We retrospectively examined their clinical characteristics and conducted p16 immunohistochemistry and HPV detection. We found that 12.7% of the patients exhibited p16 overexpression, which was significantly more common in the nasal cavity and increased from 2015 onward. The HPV was a high-risk type and viral loads ranged from 4.2 to 1.6 × 106 copies/ng DNA with genome integration. Five-year overall survival (OS) and five-year relapse-free survival (RFS) rates were 74.6% and 69.9%, respectively. Our multivariate analysis showed that T category (T1–4a) and hemoglobin levels (≥13.7) were significant favorable prognostic factors for OS, while T category, performance status, and p16 overexpression were significantly associated with RFS. In patients with p16 overexpression, OS was 100% and RFS was 90%. Our findings suggest that p16 overexpression is a reliable surrogate marker for transcriptionally active HPV infection and predicts a favorable prognosis.
E-Health: A Game Changer in Fetal and Neonatal Cardiology?
Authors: Padovani Paul , Singh Yogen , Pass Robert H. , Vasile Corina Maria , Nield Lynne E. , Baruteau Alban-Elouen
Published: October 2023

Technological advancements have greatly impacted the healthcare industry, including the integration of e-health in pediatric cardiology. The use of telemedicine, mobile health applications, and electronic health records have demonstrated a significant potential to improve patient outcomes, reduce healthcare costs, and enhance the quality of care. Telemedicine provides a useful tool for remote clinics, follow-up visits, and monitoring for infants with congenital heart disease, while mobile health applications enhance patient and parents’ education, medication compliance, and in some instances, remote monitoring of vital signs. Despite the benefits of e-health, there are potential limitations and challenges, such as issues related to availability, cost-effectiveness, data privacy and security, and the potential ethical, legal, and social implications of e-health interventions. In this review, we aim to highlight the current application and perspectives of e-health in the field of fetal and neonatal cardiology, including expert parents’ opinions.
The Role of Extracellular Matrix and Inflammation in the Stratification of Bleeding and Thrombotic Risk of Atrial Fibrillation on Oral Anticoagulant Therapy: Insights from Strat-Af Study
Authors: Alfano Francesco , Cesari Francesca , Gori Anna Maria , Berteotti Martina , Salvadori Emilia , Giusti Betti , Bertelli Alessia , Kura Ada , Barbato Carmen , Formelli Benedetta , Pescini Francesca , Fainardi Enrico , Chiti Stefano , Marzi Chiara , Diciotti Stefano , Marcucci Rossella , Poggesi Anna
Published: October 2023

In anticoagulated atrial fibrillation (AF) patients, the validity of models recommended for the stratification of the risk ratio between benefits and hemorrhage risk is limited. We hypothesize that both circulating and neuroimaging-based markers might improve the prediction of bleeding and thrombotic risk in anticoagulated AF patients. The Strat-AF study is an observational, prospective, single-center study enrolling 170 patients with AF; recruited patients are evaluated by means of a comprehensive protocol, with clinical, cerebral magnetic resonance imaging and circulating biomarkers assessment. The main outcome is the evaluation of cerebral microangiopathy related to the levels of circulating biomarkers of inflammation and extracellular matrix (ECM) remodeling. At multivariate logistic regression analysis adjusted for age, sex, CHA2DS2-VASc, HAS-BLED and type of anticoagulant, matrix metalloproteinases (MMP)-2 levels were significantly and positively associated with the presence of cerebral microbleeds (CMBs). A significant association between MMP-2, tissue inhibitor of metalloproteinases (TIMP)-1,-2,-4 levels and white matter hyperintensity was also found. Concerning the small vessel disease (SVD) score, MMP-2 and TIMP-1,-2 levels were associated with the presence of two and three or more signs of SVD, whereas TIMP-4 levels were associated with the presence of three signs of SVD with respect to patients with no instrumental signs of SVD. As regarding the presence of enlarged perivascular spaces (EPVS), a significant association was found for high levels of interleukin (IL)-8 and TIMP 1-2-3. These results demonstrate that patients with AF have evidence of impaired ECM degradation, which is an independent risk factor for thrombotic complications of AF patients on oral anticoagulant therapy. The incorporation of these markers in the prognostic schemes might improve their clinical capability in predicting stroke risk and thrombotic complications.
Effectiveness of Protective Measures and Rules in Reducing the Incidence of Injuries in Combat Sports: A Scoping Review
Authors: Štyriak Rastislav , Hadža Radovan , Arriaza Rafael , Augustovičová Dušana , Zemková Erika
Published: October 2023

In recent years, much effort has been made to reduce the injury rate in combat sports. However, the question remains to what extent these measures are effective. Analysis of studies could provide evidence of the effectiveness of measures aimed at reducing the incidence of injuries. This scoping review aims (1) to map research articles dealing with the effectiveness of proper use of protective measures in reducing the incidence of injuries in combat sports; (2) to investigate to what extent the proper use of protective measures and compliance with sports rules help to reduce the incidence of injuries in combat sports; and (3) to identify gaps in the existing literature and suggest future research on this topic. The literature search was conducted on articles published between 2010 and 2023. The main inclusion criteria were studies investigating the effect of sports rules and protective equipment used during training or competition in combat sports on reducing the incidence of injuries. After meeting the criteria, only seven articles from boxing, karate, and taekwondo were included in this study. Results showed that mandatory head guards, along with modern thicker gloves, significantly reduced the rate of knockouts (KOs) and head injuries in boxing despite an increase in the number of head blows. However, the number of facial cuts increased significantly due to the removal of head guards as a piece of mandatory equipment. The use of mouth guards has significantly reduced the number of oral injuries. Changes in rules, such as shortening the duration of bouts, along with the introduction of greater competencies of referees in the supervision of bouts (the standing count, outclassed rule, and medical stops) have helped to reduce the rate of injuries in boxing. The application of a computerised scoring system also contributed to the rate of injuries reduction. The increase in the number of weight divisions had the same effect on U21 karate athletes. However, a higher incentive to attack the head area in taekwondo did not increase the incidence of injuries in youth athletes. It can be concluded that the proper use of protective measures (head and mouth guards) in combination with the rules established for health protection (higher competencies of referees and more weight divisions in competitions) effectively reduces the occurrence of injuries in combat sports. In all Olympic combat sports, the injury incidence should be regularly assessed using the Injury Incidence Rate (IIR) per 1000 min exposures (MEs). Nonetheless, further studies are needed to monitor how established rules (e.g., prohibited behaviour) affect the IIRs.
The Effects of Personalized Nudges on Cognitively Disengaged Student Behavior in Low-Stakes Assessments
Authors: Arslan Burcu , Finn Bridgid
Published: October 2023

In educational settings, students rely on metacognitive processes to determine whether or not to exert effort. We investigated ways to minimize cognitively disengaged responses (i.e., not-fully-effortful responses) during a low-stakes mathematics assessment. Initially, we established theory-driven time thresholds for each item to detect such responses. We then administered the test to 800 eighth-graders across three conditions: (a) control (n = 271); (b) instruction (n = 267); and (c) nudge (n = 262). In the instruction condition, students were told to exert their best effort before starting the assessment. In the nudge condition, students were prompted to give their best effort following each first-attempt response that was both incorrect and not-fully-effortful. Therefore, students had multiple opportunities to adjust their level of effort. Nudges, but not effort instruction, significantly reduced students’ not-fully-effortful responses. Neither the nudges nor the effort instruction significantly impacted performance. In a post-test survey, most students reported that they received nudges whenever they did not know the answer (55%). Overall, these findings suggest that while nudges reduce cognitively disengaged responses, most students appear to strategically modulate their level of effort based on self-monitoring their knowledge and response effort.
A Virtual System and Method for Autonomous Navigation Performance Testing of Unmanned Surface Vehicles
Authors: Xiao Guoquan , Zheng Guihong , Tong Chao , Hong Xiaobin
Published: October 2023

An overall framework of the virtual testing system has been established based on the analysis of the virtual testing requirements for autonomous navigation performance of unmanned surface vehicles (USVs). This system consists of several modules, including the environment module, motion module, sensor module, and 3D visualization module. Firstly, within the robot operating system (ROS) environment, a three-dimensional navigation environment was generated by combining actual wave spectra with Gerstner waves. By designing a power plugin for USV navigation, the system was made to reflects the coupled motion model of USVs in wind, waves and currents, along with predictive results. Regarding the four typical sensor information on USVs, the actual sensors were virtualized, and a simulation approach for virtual sensor information is provided. The three-dimensional visualization of USV’s motion enables the intuitive display and analysis of the virtual testing process. Based on the prediction of coupled motion characteristics in wind, waves and currents, the interaction between USVs and the virtual testing system has been realized. A platform for virtual testing experiments to determine the autonomous navigation performance of USVs was established, and the effectiveness of the platform was verified in terms of perception and environmental interference. In virtual environmental interference validation, the average amplitude deviation of the heave motion of USVs under sea state 3 reaches 0.74 m, and the average amplitude deviation of the pitch motion reaches 0.25 rad, showing the gradually increasing disturbance of the sea state. Finally, virtual testing experiments were conducted on a specific USV to evaluate its autonomous navigation perception performance, trajectory tracking performance, and autonomous obstacle avoidance. The evaluation results indicate that the platform can achieve the functionality of virtual testing for the autonomous navigation performance of USVs from the perspective of cost function, taking the reaction distance, regression distance, and obstacle avoidance time into consideration. A representative example is that the cost function deviation rates of overtaking obstacle avoidance between static and dynamic seas reach 5.11%, 8.98% and 18.43%, respectively. The gradually increasing data shows that the virtual simulating method matches the drifting-off-course tendency of boats in rough seas. This includes acquiring perception information of navigation and simulating the motion and navigation processes for visualization. The platform provides new means for testing and evaluating the autonomous navigation performance of USVs.
Spatial Variability in the Primary Production Rates and Biomasses (Chl a) of Sea Ice Algae in the Canadian Arctic–Greenland Region: A Review
Authors: García Laura Martín , Sorrell Brian , Søgaard Dorte Haubjerg , Lund-Hansen Lars Chresten
Published: October 2023

The aims of this review are to elucidate the spatial variation in the primary production rates and biomasses (Chl a) of sea ice algae in the Canadian Arctic–Greenland region, characterized by its comparable physical settings. A database was compiled from 30 studies of the production rates and biomasses (Chl a) of sea ice algae, the snow and ice thicknesses, ice types, nutrients (Si(OH)4, PO4, (NO3 + NO2)), and NH4 concentrations in the ice and below the ice from the region. Production rates were significantly higher (463 mg C m−2 d−1) in Resolute Bay and Northern Baffin Bay (317 mg C m−2 d−1), both in the Canadian Arctic, compared to a rate of 0.2 mg C m−2 d−1 in northeast Greenland. The biomasses reached 340 mg Chl a m−2 in Resolute Bay in comparison to 0.02 mg Chl a m−2 in southwest Greenland. Primary production at other Canadian and Greenland sites was comparable, but sea ice Chl a was higher (15.0 ± 13.4 mg Chl a m−2) at Canadian sites compared to Greenland ones (0.8 ± 0.5 mg Chl a m−2). Resolute and Northern Baffin Bay production rates were significantly higher when compared to other Arctic Ocean sites outside the studied region. The review concludes that the high production rates and biomasses in Resolute and Northern Baffin Bay are related to the inflow and mixing of nutrient-rich waters of Pacific origin. A conceptual model with drivers and inhibitors of the primary production of sea ice algae is proposed, and the database is compiled into a dataset of published data for further studies.
Potential Use of Image Analysis in Breeding Programs for Growth and Yield Traits in Meagre (Argyrosomus regius)
Authors: Vallecillos Antonio , María-Dolores Emilio , Villa Javier , Afonso Juan Manuel , Armero Eva
Published: October 2023

In the present work, we studied ten new productive traits in meagre (Argyrosomus regius), comprising three related to the carcass (cNiT) and seven related to morphometric (mNiT) characteristics. We harnessed non-invasive technology (NiT) by means of the IMAFISH_ML software. This tool’s potential was leveraged on an industrial scale, encompassing the evaluation of 612 fish from two distinct rearing systems (marine cages and indoor tanks) at the time of harvest. Each fish underwent digital photography for morphometric measurements, manual weighing, and was manually eviscerated and filleted to calculate the carcass and fillet yield. Subsequently, the principal genetic parameters were estimated. The heritabilities for the growth traits were moderate (0.34 and 0.39 for TL and BW), whilst those for the cNiT traits ranged from medium to low (0.32–0.27). For the mNiT, they demonstrated a medium to low range (0.15–0.37), whereas the carcass and fillet yield heritabilities were considered to be medium to high (0.32 and 0.31). Most of the genetic correlations between the growth, NiT, and yield traits were not estimated accurately due to the limited data. As was expected, we observed predominantly high and positive correlations between the growth and mNiT. A genetic correlation to highlight was the fillet yield with the fish maximum height (0.87 ± 0.23) and with the head height (0.87 ± 0.24). This suggests that indirect selection using NiT could improve the growth and yield traits. Employing a multi-trait selection approach enables us to capture a broader spectrum of genetic variability and to potentially identify individuals with superior genetic potential. The use of image analysis software ensures objective and precise measurements, thereby reducing the potential for human error or bias during the selection process. Further studies should be carried out to improve the accuracy of the estimates, especially those of the genetic correlations.
Coupling Submarine Slope Stability and Wellbore Stability Analysis with Natural Gas Hydrate Drilling and Production in Submarine Slope Strata in the South China Sea
Authors: He Yufa , Song Benjian , Li Qingping
Published: October 2023

This research explores the geomechanical challenges associated with gas hydrate extraction in submarine slope zones, a setting posing a high risk of significant geological calamities. We investigate slope and wellbore deformations driven by hydrate decomposition within a subsea environment. Utilizing Abaqus, a fluid-solid-thermal multi-field coupling model for gas hydrate reservoirs was created. Hydrate decomposition during drilling is minimal, resulting in minor formation deformation near the wellbore. However, a year of hydrate production caused a maximum displacement of up to 7 m in the wellbore and formation, highlighting the risk of submarine landslides. This indicates the need for meticulous surveillance of formation subsidence and wellhead equipment displacement. In the aftermath of a hydrate-induced submarine landslide, both the hydrate layer and the overlying strata descend together, inflicting considerable damage on the formation and wellbore. Our study presents a holistic examination of the interplay between environmental geomechanics risks and engineering structure risks for submarine slope instability and wellbore stability during hydrate development, providing crucial insights for enhancing safety measures in hydrate drilling and production, and ensuring wellbore stability.
Design and Optimization of a New Type of Magnetic Suspension Vibration Absorber for Marine Engineering
Authors: Dai Changming , Liu Zhengyuan , Wang Yu , Lin Xiang , Liu Hui , Zhou Bo
Published: October 2023

The magnetic suspension damper, which is based on magnetic suspension technology, is receiving more and more attention from academics as active–passive hybrid damping technology develops. A new symmetric magnetic suspension structure is constructed in this study, and the accuracy of the simulation findings is confirmed by contrasting the output from finite element simulation with the theoretical formulations. On the basis of this, how the structure, size, and material of the electromagnet and armature affect the magnetic flux density, electromagnetic force, and suspension force is investigated. The structure optimization of the electromagnet and armature was performed in accordance with the simulation results, and a new symmetric magnetic suspension structure was produced. The results of the simulation demonstrate that DT4(electrical pure iron) is the ideal material for armatures and electromagnets. The reinforcing ring construction can be built up by the armature to increase suspension force. The suspension force output by the armature will be greatly increased when the size and placement of the reinforcing ring structure are right. The system stiffness adjustment range will expand at this point, enhancing the magnetic suspension damper’s functionality. This study offers novel perspectives for designing structures that reduce vibration and noise in various projects and serves as a guide to constructing magnetic suspension dampers.
Technology Review of Cabled Ocean Observatories
Authors: Shu Chang , Lyu Feng , Xu Rendong , Wang Xichen , Wei Wei
Published: October 2023

Cabled ocean observatories (COOs) have enabled real-time in situ ocean observations for decades, thereby facilitating oceanic understanding and exploration. This review discusses typical COOs worldwide in terms of system configurations and state-of-the-art technology, including network structures, power supply modes, and communication capabilities, and provides a comprehensive analysis of their technical routes. The main characteristics of line, ring, star, and grid networks and their applicability in COOs are elucidated, and the advantages and disadvantages of various power supply modes, as well as the opportunities brought by the development of communication technologies, are described. The insights gained from these discussions can inform the implementation of grid structures, optimization of cable routings, expansion of COO scales, application of dual-conductor submarine cables, and upgrading of communication capacity. On this basis, the challenges and future research directions related to COOs are presented.
Fatigue Life Assessment in the Typical Structure of Large Container Vessels Based on Fracture Mechanics
Authors: Liu Jinfeng , Feng Guoqing , Wang Jiaying , Ren Huilong , Song Wei , Lin Panpan
Published: October 2023

Welding defects are known to cause crack propagation and reduce structural fatigue performance. Based on the Paris theory of fracture mechanics, research is conducted on evaluation methods for analyzing fatigue crack propagation by adopting random loads with long-term distribution that follows the Weibull distribution for the stress ranges of fatigue loads. This approach is combined with the corrective stress intensity factor (SIF) equation and the method for calculating the reference stress and failure criterion. A large container ship is selected for a simulation, and fatigue crack propagation analysis is conducted on typical critical locations. A detailed comparison of the forecasted fatigue life is carried out between fracture mechanics theory and the S-N curve. The results indicate that the fatigue life values obtained using the two methods are of the same magnitude. In general, for the welded structure, the fatigue life value obtained via the fracture mechanics method is shorter than that obtained via the S-N curve method, while, for the free edge of the structure and the unwelded structure, the predicted fatigue life value is closer than that predicted via the S-N curve method. Moreover, the influence of initial crack defects on the fatigue life is investigated, and the results show that the depth of the initial crack will greatly affect the fatigue life of the target ship in typical locations, but the influence of the shape ratio on the fatigue life is limited. Therefore, in the actual ship construction process, controlling the initial crack depth of components is effective for limiting crack propagation and improving fatigue life. The above conclusions and suggestions can serve as a reference for the structural design and fatigue life evaluation of large container ships.