bluuebunny/crossref_metadata_2025 huggingface dataset:
Features of neuroimmune and genetic profile in men with clinical manifestations of vegetative vascular dystonia of hypertensive type
Authors: Dolgikh Oleg V. , Zaitseva Nina V. , Nikonoshina Natalya A. , Alekseev Vadim B.
Published: November 2023

Background. Identification of immune, neurohumoral and genetic markers of vegetative vascular dystonia of the hypertensive type is relevant in the aspect of prevention and early diagnosis of cardiovascular pathology in middle-aged men.
Aim. To study the features of the immune and neurohumoral profile in middle-aged men with clinical manifestations of vegetative vascular dystonia of the hypertensive type, associated with polymorphic variants of candidate genes for blood vessel tone regulation.
Material and methods. 113 middle-aged men (mean age 46.1±3.9 years) were examined. The observation group included 65 men (average age 45.3±4.6 years) with clinical manifestations of vegetative vascular dystonia of the hypertensive type. The comparison group included 48 men without signs of autonomic regulation dysfunction (average age 48.3±3.2 years). The groups were comparable in age (p=0.593), ethnic and social composition. The content of CD3+CD95+ lymphocytes was determined by flow cytometry; interleukin-6, total immunoglobulin E, adrenaline, serotonin — by enzyme immunoassay. Polymorphic variants of the genes ADRB2 (rs1042713), ADD1 (rs4961), GNB3 (rs5443), HTR2A (rs7997012) were identified by real-time polymerase chain reaction. Statistical processing: comparison of arithmetic means using Student's t-test or Mann–Whitney U-test, calculation of odds ratio (OR) and 95% confidence interval (CI).
Results. The immune profile of men with disorders of autonomic regulation was characterized by a deficiency of CD3+CD95+ lymphocytes against the background of overproduction of total immunoglobulin E and interleukin-6. The neurohumoral profile was characterized by excessive synthesis of adrenaline and serotonin. The development of symptoms of vegetative vascular dystonia of the hypertensive type was associated with the G allele of the ADRB2 gene (rs1042713) (OR=1.80; 95% CI=1.05–3.08; p 0.05), the G allele of the ADD1 gene (rs4961) (OR=3.51; 95% CI=1.27–9.67; p 0.05), C allele of the GNB3 gene (rs5443) (OR=2.30; 95% CI=1.21–4.37; p 0.05), A allele of the HTR2A gene (rs7997012) (OR=2.38; 95% CI=1.37–4.15; p 0.05).
Conclusion. Changes in the immune profile were identified (deficiency of CD3+CD95+ lymphocytes, excess of total immunoglobulin E, interleukin-6), associated with hyperproduction of adrenaline and serotonin against the background of polymorphism of candidate genes for vascular tone regulation [ADRB2 (rs1042713), ADD1 (rs4961), HTR2A (rs7997012 ), GNB3 (rs5443)].
Research on the Impact of Logistics Outsourcing Cooperation in China’s Internet E-commerce on Logistics Achievements
Authors:   The Korean Logistics Research Association, Wang Limei , Bae Ki-Hyung
Published: November 2023

This study focuses on increasingly competitive Chinese e-commerce enterprises and explores the impact of logistics outsourcing partnerships on service expansion and logistics outcomes in supply chain strategy. The research results show that among the determining factors of logistics outsourcing, reducing costs will affect the improvement of service levels in addition to traditional functions, as well as considerations for the use and compatibility of information systems (+). Among the determining factors of logistics outsourcing, the improvement of service level and the utilization and compatibility of information systems have a positive (+) impact on the level of logistics outsourcing. In addition, besides traditional functions, all other functions in the outsourcing level have a meaningful impact on logistics efficiency and effectiveness. In the context of logistics outsourcing decisions, cost reduction has been confirmed as an extremely critical factor. Companies should focus not only on outsourcing traditional logistics functions but also on improving service levels and enhancing the utilization and compatibility of information systems to achieve cost savings. The effective utilization of information systems and compatibility are key elements in elevating the level of outsourcing. Companies need to develop and enhance their ability to effectively use information systems while maintaining compatibility with other systems, which contributes to increased efficiency in logistics management. Furthermore, this underscores the importance of viewing outsourcing as a strategic tool rather than just a means for cost reduction, allowing companies to gain a competitive edge. To achieve the best results, a comprehensive approach that considers both traditional functions and service-related aspects, along with information system functionalities, is necessary. Such an integrated approach is expected to enhance the level of logistics outsourcing and optimize logistics performance.
The Effect of Macronutrient-Induced Ketosis on Prefrontal Cortex Neural Activity and Cognition
Authors:   , Altayyar Mansour , Nasser Jennifer
Published: November 2023

Cognitive functions are crucial for daily activities, social interactions, and independent living; unfortunately, a decline in cognitive abilities can occur in advanced age and diseases like Alzheimer's. The concurrent deficiency in the brain's glucose metabolism contributes to the ominous process of impaired cognition by partly causing a gap between the energy supply and demand needed by the brain. However, the metabolism of the body's alternative fuel, known as ketone bodies, remains stable and may rescue the brain from cognitive deterioration when they rise to supraphysiological levels (ketosis). This dissertation project aimed to investigate the acute influence of ketosis on the cognitive brain neurophysiology and activation to understand the contribution of ketone bodies to the cognitive brain energy flow that may contribute to cognitive benefits. With the use of a double-blind single-case experimental design of a young participant with 20 randomized data points spread between two food interventions, the results indicated that a food mix containing purified Medium Chain Triglycerides (MCT) successfully induced ketosis (>0.5 mmol/L) from basal 15-hour fasting levels. Also, compared to after prolonged fasting, data from a wearable functional near-infrared spectroscopy that detects hemoglobin oxygenation changes as a surrogate of brain activation have shown a significant decrease in oxygenated hemoglobin met with an increase in deoxygenated hemoglobin at the dorsolateral prefrontal cortex as a consequence of ketosis during the engagement in a demanding cognitive N-back test. This change was unique only under a ketosis state; the absence of ketosis in the fasting state and the comparative non-MCT food mix did not lead to the aforementioned neurophysiological changes and showed an increase in oxygenated hemoglobin and decrease in deoxygenated hemoglobin which is typical activation changes during cognitive tasking under usual physiological circumstances. Nevertheless, regardless of ketosis status, improvement in cognitive performance was not noted. From the results of this project herein, the enhancement of oxygen consumption during cognitive brain activation highlights the efficiency of ketone bodies in optimizing the brain's bioenergy cycle and promoting mitochondrial respiration, which may bear clinical significance later in life.
Commentary on the publication of Yargunin S.A. et al. “Dynamics of changes in tumor-associated macrophages in patients with primary skin melanoma depending on the method of surgical treatment”
Authors: Петенко Н. Н. , Кузьменко А. О. , Самойленко И. В.
Published: November 2023

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Comments on the publication of Khakimov G. A. et al. “Successful surgical treatment of chemoresistant mediastinal germ cell tumor”
Authors: Румянцев А. А. , Федянин М. Ю. , Исраелян Э. Р. , Тюляндин С. А.
Published: November 2023

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Revolutionizing Commerce: The Dynamics and Future of E-Commerce Web Applications
Authors: Rahman Shati Sarmin , Dekkati Sreekanth
Published: November 2023

Modern business relies on e-commerce, changing how we buy and sell. E-commerce evolved from electronic data exchange to internet-driven platforms. E-commerce is a dynamic force that will continue to affect markets and trade. This article explores the ever-evolving landscape of e-commerce, shedding light on its dynamic nature and prospects. It also delves into the key drivers of change in online retail, such as technological advancements, consumer behavior shifts, and market competition. It also examines the role of web applications in shaping the e-commerce experience, emphasizing the importance of user-friendly interfaces, personalization, and seamless transactions. By analyzing these factors, the article offers insights into the future of e-commerce, highlighting emerging trends and strategies for businesses to stay competitive in this rapidly evolving sector.
Costeo empaques de panela, planta de café Majavita.
Authors: Sastre Martínez Dara Daniela , Benítez Heredia Oscar Eduardo , Muñoz Torres Josef Grimaldi , Gualdrón López Alfonso Enrique
Published: November 2023

En la Hacienda Majavita de la Universidad Libre Seccional Socorro funciona la Planta de Café́ Majavita, la cual tiene como actividad principal la producción y procesamiento de café́. Sin embargo, en esta se desarrollan otras actividades como lo son el empaque de panela en sobres, los cuales se distribuyen en las sedes de la Seccional Socorro como endulzantes.

El objetivo de esta investigación es determinar los costos de producción que conllevan la producción de empaques de panela a través de la aplicación de un sistema de costeo. En este caso se aplicaron dos costeos: variable y total.
Análisis de las precipitaciones mensuales en el municipio de Zipaquirá- Cundinamarca en los años de 1994 -2018
Authors: Gómez Ayala Sandra Liliana , Marín Juan Pablo , Vanegas Parra Yeidy Adriana
Published: November 2023

En el presente trabajo se evaluó la variación de la precipitación en la estación Zipaquirádel departamento de Cundinamarca durante los años 1994 hasta el 2018, la información se obtuvo de la base de datos del gobierno colombiano. La forma del procesamiento de la información se realizó́ por medio de la herramienta MegaStat obteniendo datos estadísticos como media, rango, puntos máximos y mıń imos para la variable de precipitación y el comportamiento a través de los años con los fenómenos del niño y la niña. Como resultados de la investigación para las medidas de tendencia central se evidenció un coeficiente de variación muy alto en todos los años, solo en los tres años presenta una similitud en los datos, con una media de 74.78 mm/L año, 76.24 mm/L año y de 75.23 mm/L año. El año 2011 obtuvo mayores lluvias con 1435.4 mm/L año y el año más seco fue el 2015 con 492.3 mm/L año. De acuerdo con los datos obtenidos por la Administración Nacional Oceánica y Atmosférica (NOAA) en los años 1999 y 2000 se evidenció presencia del fenómeno de la niña en todos los trimestres, y el trimestre de Nov-Dic-Ene, es el más caluroso y se encuentra en el 2015
Theruptor novo: wound dressing for diabetic foot ulcer
Authors: Pavan B.
Published: November 2023

One of the main risk factor affecting the normal wound healing process of is diabetes. India being the capital for diabetes, has a prevalence of 9.6% with 74 million patients living with diabetes and is expected to be 124 million by 2045. The most dreadful complication of diabetes mellitus is the diabetic foot ulcer. Foot ulcer and amputation are among the leading reasons for high morbidity, healthcare costs and mortality in diabetes patients. Numerous things must come together for a chronic wound to heal, and one crucial component of care is the use of wound dressings and these should create an ideal environment for healing while safeguarding the site from infection and additional damage. A diabetic patient presented with a non-healing diabetic foot ulcer (10.83 cm2) with severe loss of protective sensation, exposed excised fourth and fifth metatarsals and he was treated and followed up with regular normal saline washes and Theruptor Novo dressings. The wound started to show signs of healing and within 7 weeks, the wound healed with complete epithelization. Theruptor Novo dressing was helpful in terms of good granulation tissue growth and epithe­lialization over time with good exudate management. Theruptor Novo, a non-adherent dressing with unique antimicrobial action cab be useful in managing diabetic foot ulcers.
Importance, indication and safety of maternal immunization
Authors: Omar Baoum Shada , Sumayli Abdulqader Ali , Algahtani Rahaf Osama , Alshilash Aseel Mohammed , Esmael Emtenan Ali , Alfajri Ahmad Abdrabalamier , Alharbi Aisha Wasl , Alenezi Sarah Ali , Ahmed Amani Izzeldin , Al Arfaj Abdulaziz Saeed , Alshehri Haya Hamad
Published: November 2023

Vaccination is a very important spectrum for building immunity to fight certain infections. Doing vaccination on the mother as well as the baby, which safeguards both of them, is known as maternal immunization. After childbirth, babies are prone to get infected by many diseases as their immunity is inferior during that time. Over the years, numerous studies have shown that vaccinating mothers can effectively reduce the risk of illnesses such as smallpox, polio, etc. This vaccination process helps strengthen the body's system and enables it to combat these diseases effectively when necessary. This approach works by boosting the transfer of antibodies from the person to the fetus through the placenta, providing passive immunity to the infant during their initial months of life until they become eligible for their own vaccines. In addition to protecting infants, maternal immunization can also help prevent complications for individuals caused by infections that could impact their health and pregnancy outcomes. This review focuses on discussing the significance, indications, and safety of immunization for diseases that pose a high risk to both pregnant individuals and their infants.
Theruptor Novo dressing for an infected diabetic foot ulcer: a case study
Authors: Pavan B.
Published: November 2023

In diabetes mellitus (DM) patients with peripheral neuropathy, the diabetic foot infection (DFI) often begins with a small wound that patients may not easily detect and then progresses to a more complex wound. Diabetic foot ulcer (DFU) is estimated to occur in approximately in 25% of individuals with diabetes in India. The bacterial infection is one of the important cause for the chronicity of DFU and are accountable for the high medical costs as well as affecting patients’ quality of life significantly. Preventing DFU secondary infections is an important function of wound dressing. There are many wound dressings available for DFU, and choosing the right dressing is one of the important parameter in the management and ultimately preventing the limb amputation. In this case, the patient presented with non-healing infected DFU and we used Theruptor Novo dressings for the wound management. The Theruptor Novo dressing was efficient in exudate management and preventing secondary infection which helped in accelerated DFU healing.
Volumetric analysis of pharyngeal airway dimensions and hyoid bone position following orthognathic surgery in skeletal class III patients: a cross sectional cephalometric study
Authors: Thapa Amrit , Roy I. D. , Jayan B. , Ray Saugat , Kumar Andrews Navin , Antil Amit
Published: November 2023

Background: Objective of the study was to determine linear and volumetric changes in pharyngeal airway dimensions in class III patients treated by different modalities of orthognathic surgery and to compare the results of different orthognathic surgical modalities, and determine the change at the position of the hyoid bone.
Methods: Pre and post-treatment lateral cephalogram of 53 class III adult patients who were treated by different modalities of orthognathic surgery studied to assess the changes in pharyngeal airway dimensions and hyoid bone position after orthognathic surgery. 28 patients were treated with mandibular set back, and 25 patients were treated with Bijaw surgery. Lateral cephalogram records were taken before treatment (T1), after surgery (T2), the end of the fixed treatment (T3) and 1 year after debonding (T4).  
Results: Interception of both surgical modalities has significant impact on various skeletal and pharyngeal parameters i.e., BMeH (0.00), PNS (0.009), MPS (0.13), GOP (0.001), IPS (0.007), SAS (0.006), and MAS (0.00). OJ (overjet) and OB (overbite) was significant especially after time interval of one year. In Bijaw groups, PPST4 parameter was significantly increased (0.0000), SPST4 (0.000), GOP (0.000), EPS (0.000) and IPS parameter was significantly decreased (0.045). Significant difference was observed in T4 time interval in superior pharyngeal airway space, posterior airway space and middle airway space with (p<0.05).
Conclusions: Pharyngeal airway is significantly altered following orthognathic surgery in class III patients and it depends on the type of surgical modality employed were Bijaw surgery has significant impact on oropharyngeal and hypopharyngeal airway space.
Research Insights: Slums and Pandemics: How Did Intra-City Heterogeneity Affect the Dynamics of COVID-19?
Authors: Santos Cezar , Brotherhood Luiz , Cavalcanti Tiago , Da Mata Daniel
Published: November 2023

Disease outbreaks can affect vulnerable people disproportionately, contributing to the increase in health and economic disparities. Social distancing increased less in areas with slums than in other areas after the adoption of non-pharmaceutical interventions (NPIs) in Rio de Janeiro and São Paulo. NPIs can have heterogenous effects across different groups (slum versus non-slum residents, for example).
A Young Carmelite on Ice Skates. The Early Occasional Poetry of St. Titus Brandsma as a Literary Testimony of His Love of God, Life, and the Family
Authors: Polkowski Marcin
Published: November 2023

The recently canonised Dutch Carmelite Titus Brandsma (1881–1942), World War II martyr, mystic, Catholic journalist and historian of spirituality, was also – what is less known – a talented poet. The article recalls his early occasional poetry, written in Dutch and Frisian between 1898 and 1906 for members of his immediate family. Its literary characteristics are presented, demonstrating that this poetry is a valuable testimony to the saint’s views on human life from an eschatological perspective, including topics on the family, marriage, and the relationship between children and parents. This justifies recognising St. Titus Brandsma’s occasional poetry as an expression of his unique poetic theology of the family. The article also includes an English translation of a hitherto untranslated poem by St. Titus Brandsma.
Recovery of Total Chromium from Tannery Wastewater by Carbonization Application
Authors: Ochoa P. E , Gavilánes S L , Achote J S , Alban M A
Published: November 2023

A carbonization process was carried out for the recovery of chromium from wastewater by chemical treatment with sodium hydroxide as a basic solution in contact with the precursor material at different concentrations [1:0.15 (%w/w) - 1:0.20 (%w/w)]. The physical treatment was carried out with carbonization at 700∘C for a period of 2 hours. The obtained samples were characterized by elemental analysis, thermogravimetric analysis (TGA), Fourier transform infrared spectroscopy (FT-IR), atomic absorption spectroscopy, and surface area analysis (BET) to validate the evidence of metal recovery. The results indicate that the percentage of total chromium recovery was 47.62% with respect to the uncarbonized material, establishing that the best carbonization variables are at 700∘C and concentration 1:0.20% w/w for 2 hours.
Keywords: tannery industry, carbonization, recovery, total chromium.
Resumen
Se realizó un proceso de carbonización para la recuperación de cromo a partir de aguas residuales mediante un tratamiento químico con hidróxido de sodio como solución básica en contacto con el material precursor a diferentes concentraciones [1:0,15 (%p/p)- 1:0,20 (%p/p)], el tratamiento físico se realizó con la carbonización a 700∘C por un lapso de 2 horas. Las muestras obtenidas se caracterizaron mediante análisis elemental, análisis termogravimétrico (TGA), espectroscopia infrarroja por transformada de Fourier (FT-IR), espectroscopia de absorción atómica y análisis de área superficial (BET) para validar la evidencia de la recuperación del metal. Los resultados indican que el porcentaje de recuperación de cromo total es de 47,62% respecto del material sin carbonizar estableciendo que las mejores variables de carbonización son 700 ∘C y concentración 1:0.20 %p/p por 2 horas.
Palabras Clave: Industria curtiembre, carbonización, recuperación, cromo total.
Utilization of Guarango (Caesalpinia spinosa) in the Province of Loja
Authors: Cedeño H , Soto A , Malagón O
Published: November 2023

Guarango (Caesalpinia spinosa) was studied in different parts of Loja province, mainly Loja, Catamayo, Gonzanamá, and Paltas, to use this species in the food and chemical industries because many studies in our country show that this species is not correctly used. It started with studies of the yields according to the place and time of recollection, after which the correct treatment was found, like the kind of grinding to optimize the handling of the sample, the chemical determination (tannins) in the pod, and its bromatological characteristics (moisture, fat, and protein). The chemical determination of tannins was done through titration of a macerated pod using carmine indigo and KMnO4 to 0,1 N, while bromatological determination with moisture, fat, and protein was applied using the standard methods of AOAC 7003, AOAC 7.056 y AOAC 47.021, respectively. In these results, it was found that there is little variability in experiments of percent of integument, endosperm, and germ, while in experiments of moisture, the amount of pod and seeds had significant differences. In addition, the percentage of tannins was excellent for use in the leather industry. While the germen had qualities of a good food supplement due to its high fat and protein content and low moisture. Finally, a method of extraction of the guarango parts could be designed that can be easily replicable by farmers. Based on the results, we can conclude that it is possible to establish ventures with guarango (C. spinosa) due to the remarkable properties of this species in food, textiles, and other industries.
Keywords: Caesalpinia spinosa, guarango, pod, germ, used.
Resumen
Se realizó un estudio sobre el guarango (Caesalpinia spinosa) de diferentes cantones de la provincia de Loja, principalmente: Loja, Catamayo, Gonzanamá y Paltas, con la finalidad de aprovechar esta especie ofreciendo alternativas de uso dentro de la industria química y alimentaria ya que, según estudios realizados, dentro de nuestro país no es aprovechada. Se partió desde el estudio de rendimientos según el lugar y tiempos de recolección, posterior a esto se buscó el tratamiento adecuado como molienda para el manejo óptimo de la muestra, la determinación química (taninos) en vaina y bromatológica (humedad grasa y proteína). Para la determinación química (taninos) se realizó titulación al macerado de la vaina usando índigo carmín y KMnO4 al 0,1 N, mientras que para determinación bromatológica como la humedad, grasa y proteína se aplicó métodos estandarizados de la AOAC 7003, AOAC 7.056 y AOAC 47.021, respectivamente. En los resultados se obtuvo ensayos que demostraron la poca variabilidad del porcentaje de tegumento, endospermo y germen, mientras que en los ensayos de humedad, cantidad de vainas y semillas, taninos, hay variabilidades significativas.
Econometric Analysis of Remittances Sent from Spain and the United States to Ecuador Between 2010 and 2021
Authors: Villarreal Satama F.L
Published: November 2023

Remittances received by developing countries have made an important contribution to the state economy, be it for internal consumption or savings, and have resulted in a social problem in the family sphere. This work aims to analyze the behavior of remittances that come from Spain and the United States to Ecuador from 2010 to 2021, using the econometric technique of multiple linear regression and cointegration analysis. The main results indicate that it continues to be an important item in Ecuador’s GDP and balance of payments. Many households still have in remittances the basic income that the family allows. The increase in the GDP of the United States and Spain (0.79 and 0.91 respectively) are closely related to the increase in remittances to Ecuador; that is, as the variable increases, remittances increase. Therefore, it is of special interest for the government to establish adequate policies in its management.
Keywords: remittances, migration, multiple regression, cointegration analysis.
Resumen
Las remesas que receptan los países en vías de desarrollo han contribuido de manera importante en la economía estatal, sea para consumo interno, ahorro, ha traído como consecuencia un problema social en el ámbito familiar. El propósito de este trabajo es analizar el comportamiento de las remesas que provienen desde España y Estados unidos al Ecuador del 2010 al 2021, mediante la técnica econométrica de la regresión lineal múltiple y análisis de cointegración. Los principales resultados indican que sigue siendo un rubro importante en el PIB y en la balanza de pagos del Ecuador. Muchos hogares, aún tienen en las remesas el ingreso básico que les permite a la familia. El aumento del PIB de EE. UU., y España (0,79 y 0,91respectivamente) guardan una estrecha relación con el aumento de envío de remesas al Ecuador, es decir aumenta esta variable y las remesas incrementan, por lo que, es de especial interés para el gobierno para establecer políticas adecuadas en su manejo.
Palabras Clave: Remesas,Migración, Regresión múltiple, Análisis de cointegración.
Sustainability in Higher Education Institutions: Theoretical Management of the Carbon Footprint at UNESUM
Authors: Muentes J , Alcívar M , León E , Chata C
Published: November 2023

Higher education institutions (HEI) play a fundamental role, potentially generating positive and negative social and environmental impacts. The quantification of environmental indicators such as the carbon footprint (CF) within HEI allows for evaluation of the negative impact generated. In turn, the pertinent management of the CF permits valuing the environmental position of the HEI according to its level of resources consumption and generation of greenhouse gases (GHG) emissions. The objective of this study was to estimate the CF of the Universidad Estatal del Sur de Manabí (UNESUM) and to propose an integrating approach that affirms its environmental commitment to move toward being a sustainable campus. Several authors have identified that the activities of HEI and their infrastructure are essential points in management and sustainability. In this context, the integration of an environmental management system (EMS) and the green building initiative are two approaches with great potential for fulfilling the second stated objective.
Keywords: carbon footprint (CF), greenhouse gases (GHG), climate crisis, sustainability, mitigation.
Resumen
Las Instituciones de Educación Superior (IES) juegan un papel fundamental siendo potencialmente generadoras de impactos sociales y ambientales positivos y negativos. La cuantificación de indicadores ambientales como la Huella de Carbono (HC) dentro de las IES permite evaluar el impacto negativo generado; a su vez, la gestión pertinente de la HC admite valorar la posición medioambiental de la IES respecto a su nivel de consumo de recursos y generación de emisiones de Gases de Efecto Invernadero (GEI). El objetivo de este estudio fue estimar la HC de la Universidad Estatal del Sur de Manabí (UNESUM) y plantear un enfoque integrador que permita afirmar su compromiso medioambiental para encaminarse a ser un campus sustentable. Varios autores han identificado que las actividades de las IES y su infraestructura son puntos esenciales en la gestión y sostenibilidad. Bajo ese contexto, la integración de un Sistema de Gestión Ambiental (SGA) y la iniciativa de construcción ecológica son dos enfoques con un gran potencial para el cumplimiento del segundo objetivo planteado.
Palabras Clave: Huella de Carbono (HC), Gases de Efecto Invernadero (GEI), crisis climática, sostenibilidad, mitigación.
The Poetry of Travel in Mario Campana: A Theoretical Approach
Authors: Musso L. C.
Published: November 2023

Mario Campana’s poetry is one of the most representative of contemporary Ecuador. This document aims to carry out a conceptual review based on different authors that exposes the importance of the work mentioned in the context of national letters. In the aforementioned context, a reflection on poetry is proposed, with a continuous line throughout its journey through successive books by the author. This article intends from a descriptive-exploratory nature, to present a rereading of the work through analysts who account for its connection with the trip.
Keywords: Ecuadorian poetry, Mario Campana, trip
Resumen:
La poesía de Mario Campaña es una de las más representativas del Ecuador contemporáneo. El objetivo del presente documento es efectuar una revisión conceptual a base de distintos autores, que expone la importancia de la obra mencionada en el contexto de las letras nacionales. En el contexto mencionado, se plantea una reflexión sobre la poesía y un línea continua a lo largo de su recorrido a través de sucesivos libros del autor. El presente artículo pretende, desde un carácter descriptivo-exploratorio, presentar una relectura de la obra a través de analistas que dan cuenta de su vinculación con el viaje.
Palabras Clave: poesia ecuatoriana, Mario Campana, viaje
Seroprevalence of Toxoplasmosis in Blood Donors: An Investigation from the Endemicity. Non-systematic Review
Authors: Jalca JE Castro , Holguín AM Castillo , Valle Zamora YM
Published: November 2023

Toxoplasma gondii is an intracellular protozoan that causes toxoplasmosis, the most common parasitic disease in the world, which infects humans and animals. It is transmitted through cat feces through the process of excretion and ingestion of oocysts. Humans become infected by eating improperly washed vegetables, raw or undercooked meat, contaminated water, the soil or area where the cat defecates, or by transfusing infected blood. The study aims to identify, through scientific evidence, the seroprevalence of T. gondii in blood donors, considering its global endemicity. A non-systematic documentary review was used for searching articles worldwide on the topic of T. gondii seroprevalence in blood donors, in different databases such as SciELO, Google Academics, etc. A total of 27 articles that had the required information; grouping the seroprevalence results by region, obtained positive IgG and IgG + IgM. Calculating the prevalence, it was identified in Asia at 7.8%, America 32.8%, Africa 40.7%, Oceania 34%, and Europe 38.1%. In conclusion, it is convenient to carry out this type of study in each country to verify the prevalence and, in addition, to determine the incidence of infection in blood donors to calculate the risk of transmission.
Keywords: Toxoplasma, seroepidemiologic studies, antibodies, immunoglobulin G, immunoglobulin M, blood donors.
Resumen
Introducción: Toxoplasma gondii en un protozoo intracelular causante de la toxoplasmosis, la enfermedad parasitaria más frecuente del mundo la cual infecta a humanos y animales, se trasmite por medio de las heces de los gatos mediante el proceso de excreción e ingestión de los ooquistes. Los humanos se infectan al ingerir vegetales mal lavados, carne cruda o poco cocida, agua contaminada, el suelo o área donde defeca el gato, o al transfundir sangre infectada. Objetivo: identificar mediante evidencias científicas la seroprevalencia de T. gondii en donantes de sangre, considerando su endemicidad global. Metodología: se empleó una revisión no sistemática, documental realizando la búsqueda de artículos a nivel mundial del tema seroprevalencia de T. gondii en donantes de sangre, en diferentes bases como SciELO, Google Academics, etc. Resultados: un total de 27 artículos que contaron con la información requerida; agrupando los resultados de seroprevalencia por región, anticuerpos positivos IgG e IgG + IgM. Calculando la prevalencia se identificó, en Asia 7,8%; América 32,8%; África 40,7%; Oceanía 34% y Europa 38,1%. Conclusión: es conveniente realizar este tipo de estudio en cada país para comprobar la prevalencia y, además, determinar la incidencia de la infección en donantes de sangre para calcular el riesgo de transmisión.
Palabras Clave: Toxoplasma, estudios seroepidemiológicos, anticuerpos, inmunoglobulina G, inmunoglobulina M, donantes de sangre.
The Virtual Environments and Platforms in the Teaching of English
Authors: Rojas M , Macias E , Moreno U , Silva J
Published: November 2023

Abstract
The research aims to highlight the significance of virtual learning environments and platforms in promoting cognitive competencies through interactive learning. The objective is to create effective learning environments by utilizing Virtual Learning Environments and implementing platforms to enhance communicative competencies. The methodology employed for this study includes quantitative and qualitative, descriptive, and predictive approaches, using technological innovation through the implementation of the Schoology platform based on the TPACK model. The results of the study indicate that students exhibit high levels of motivation and discernment toward virtual environments, particularly in English classes. Therefore, selecting appropriate didactic resources and incorporating pedagogical mediation is crucial for optimizing learning outcomes. It is essential to educate students on the significance of learning a foreign language and how it can impact the neural structure of the bilingual brain. Virtual environments facilitate interaction between team members, leading to the creation of new networks and learning environments for the development of language and communicative competencies in another language.
Keywords: virtual environments, English teaching, technological innovation, TPACK model.
Resumen
La investigación se enfoca en la importancia de los entornos y plataformas virtuales de aprendizaje porque permiten la interacción para desarrollar competencias cognitivas, para ello el objetivo consiste en generar ambientes de aprendizaje basados en los Entornos Virtuales de Aprendizaje, mediante la implementación de plataformas y fortalecer las competencias comunicativas, con este fin la metodología tiene un enfoque cuantitativo – cualitativo, de naturaleza descriptiva y predictiva desde la innovación tecnológica con la implementación de plataforma Schoology basados en el modelo TPACK. De acuerdo a los resultados, se evidencia que existe un alto discernimiento y motivación de los estudiantes a la implementación de los entornos virtuales, en particular a las clases de inglés. Para lo cual la necesidad de una mediación pedagógica en la selección de los recursos didácticos podría potencializar aún más el aprendizaje, para ello es fundamental hacer comprender a los estudiantes la relevancia de aprender un idioma extranjero y como este cambia en la estructura neuronal y su trascendencia en un cerebro bilingüe. Por tanto, los entornos virtuales promueven la interacción entre equipos de trabajo con la finalidad de generar nuevas redes y ambientes de aprendizaje, para el desarrollo de competencias lingüísticas y comunicativas en otro idioma.
Palabras Clave: entornos virtuales, enseñanza inglesa, innovación tecnológica, modelo TPACK.
Electronic Design of a DC-DC Boost Converter for Powering a Lo-Ra Communication Board with Bioelectricity by “Plantas Andinas”
Authors: Alarcón-Maz K. , Balseca-Dahu B. , Alarcón-Maz G. , Aguay- Saquariña D.
Published: November 2023

The use of bioelectricity in various areas of science has made it indispensable to resort to new technologies to take full advantage of this natural resource. Plants are living beings, and through their biochemical processes produce a small amount of electricity derived from oxidation-reduction processes. For this reason, it is proposed to use electronic and power techniques to increase the flow of electrons produced by plants of Andean characteristics, and consequently feed a Lo-Ra type communication card, meeting the needs of long-distance data transmission, used in the collection of field information, either in areas where access or availability of power lines is complex. This proposal motivates us to continue working on sustainable energy and the exploitation of natural resources. This document details the theory, practice, and methods used to meet the objective of supplying power to a wireless communication system over a long distance. First, a description of the most important issues to be addressed is developed, and then special focus is given to the design for development of the power electronics circuit, specifically an elevator type DC-DC converter. Finally, the results obtained through the implementation used in this case are documented.
Keywords: bioelectricity, MFC, boost-converter, Andean plants, totora, Lo-Ra TTGO.
Resumen
El uso de bioelectricidad en diversas áreas de la ciencia ha hecho indispensable recurrir a nuevas tecnologías para aprovechar al máximo este recurso natural. Las plantas, como seres vivos, producen una pequeña cantidad de electricidad a través de sus procesos bioquímicos, derivada de procesos de oxidación-reducción. Por esta razón, se propone utilizar técnicas electrónicas y de potencia para aumentar el flujo de electrones producidos por plantas de características andinas, y alimentar así una tarjeta de comunicación de tipo Lo-Ra, satisfaciendo las necesidades de transmisión de datos a larga distancia, utilizadas en la recolección de información de campo, ya sea en áreas donde el acceso o la disponibilidad de líneas eléctricas es compleja Esta propuesta motiva a continuar trabajando en energía sostenible y en la explotación de recursos naturales. Este documento detalla la teoría, práctica y los métodos utilizados para cumplir con el objetivo de suministrar energía a un sistema de comunicación inalámbrico a larga distancia. En primer lugar, se desarrolla una descripción de los temas más importantes a abordar, y luego se presta especial atención al desarrollo del diseño del circuito de electrónica de potencia, específicamente un convertidor DC-DC tipo elevador; y finalmente, se documentan los resultados obtenidos a través de la implementación utilizada en este caso.
Palabras Clave: bioelectricidad, CCM, convertidor-elevador, plantas andinas, totora, TTGO Lo-Ra.
Nutrition is Perceived as an Ecosystem Service of the Mangrove by Rural People in Ecuador
Authors: Vanegas W. , Carvajal L. , D. Peñafiel D. , L. Espinel R.
Published: November 2023

The mangrove ecosystem is considered as the source of livelihood, particularly for coastal areas. This study explores the perception of the inhabitants of Puerto El Morro and the island of Costa Rica (Ecuador) against the ecosystem services of the mangrove. Seven quantitative variables were used on the Likert scale by performing exploratory factor analysis. The results were based on a sample of 94 participants finding 2 factors, tourism (29.07% of variance) and nutritious food production (25.45% of variance remaining). The reliability of the questionnaire was acceptable according to Cronbach’s Alpha 0.654. A confirmatory factor analysis is necessary to revalidate the items of the factors.
Keywords: coastal communities, eating, mangroves, livelihoods, nutrition.
Resumen
El ecosistema de manglar se considera fuente de medios de vida, en particular para zonas costeras. Este estudio explora la percepción de los habitantes de Puerto El Morro y la isla Costa Rica (Ecuador) frente a los servicios ecosistémicos del manglar. Se utilizaron 7 variables cuantitativas en escala de Likert realizando análisis factorial exploratorio. Los resultados parten de una muestra de 94 participantes, hallando 2 factores: turismo (29,07% de varianza) y producción alimentos nutritivos (25,45% de varianza restante). La confiabilidad del cuestionario fue aceptable según el Alfa de Cronbach 0.654. Es necesario un análisis factorial confirmatorio para revalidar los ítems de los factores.
Palabras Clave: comunidades costeras; alimentación; manglares; medios de vida; nutrición.
Post-vaccination Symptoms with Second Dose of AstraZeneca in a Sample of Immunized Population of Ecuadorian Public Servants
Authors: Arias TV Carpio , Hernández RC Saeteros , Herrera Cisneros P , Ruiz GR Inca
Published: November 2023

Since AstraZeneca is a new vaccine against SARSCOV2, it should be monitored worldwide. This study presents the adverse reactions caused by the second dose of the AstraZeneca vaccine. Thequantitative, descriptive, cross-sectional research used a validated survey conducted on 428 public staff who were vaccinated with the second dose of the ChAdOx1-S vaccine at the Escuela Superior Politécnica de Chimborazo, the results were processed in Jamovi. 289 respondents reported having symptoms after inoculation, women (13.15%) presented more symptoms than men (7.27%). Most of the symptoms, both local and systemic, were mild and subsided with the administration of oral analgesics and lasted up to three days in 50% of the cases. AstraZeneca’s vaccine proves to be a safe biologic vaccine to generate antibodies against SARSCOV” in the adult population, and its use is therefore recommended.
Keywords: drug-related side effects and adverse reactions, coronavirus infections, pharmacovigilance
Resumen
Introducción: Dado que se trata de una nueva vacuna contra el SARSCOV2, debe ser monitoreada a nivel mundial, el presente estudio presenta las reacciones adversas presentadas con la segunda dosis de la vacuna AstraZeneca. Materiales y Métodos: La presente investigación cuantitativa, descriptiva, transversal, utilizó una encuesta validada aplicada a 428 funcionarios públicos que fueron vacunados con la segunda dosis de la vacuna ChAdOx1- S en la Escuela Superior Politécnica de Chimborazo, los resultados fueron procesados en Jamovi . Resultados: 289 encuestados informaron tener síntomas después de la inoculación, las mujeres (13,15%) presentaron más síntomas que los hombres (7,27%). La mayoría de los síntomas, tanto locales como sistémicos, fueron leves y cedieron con la administración de analgésicos orales y duraron hasta tres días en el 50% de los casos. Conclusiones: La vacuna de AstraZeneca demuestra ser una vacuna biológica segura para generar anticuerpos frente al SARSCOV” en la población adulta, por lo que se recomienda su uso.
Palabras Clave: kwd2.
DETERMINATION OF THE IONIZATION CONSTANT OF FAVIPIRAVIR API
Authors: Scrypynets Yu. V. , Fedosenko G. O. , Maltsev G. V. , Chebotars'ka I. I. , Aleksandrova D. I. , Kashutskуy S. N. , Yegorova A. V.
Published: November 2023

One of the aspects of studying the physical and chemical properties of compounds is the establishment of their ionization constants. These indicators are extremely important from both a theoretical and a practical point of view.
Theoretical analysis of proteolytic equilibria and potentiometric titration of an aqueous solution of an oral antiviral drug approved for the treatment of influenza in Japan, AFI favipiravir, were carried out in the paper.
The presence of a hydroxy group in the third position of the pyrazine cycle in the molecule determines the ability of favipiravir to exhibit acid-base properties. According to acid-base titration, the ionization constant of Favipiravir API was determined: pKa = 5.05 ± 0.02. On the basis of the found pK value, the degree of formation of protolytic forms was calculated depending on the pH of the solution. It was established that favipiravir API in solutions exists in two protonated (non-ionized), tautomeric forms A1H and A2H and one deprotonated (ionized) form A-.
Based on the calculations, the following conclusions can be drawn:
- at a pH value of the solution from 0 to 3.5, approximately 100% of the substance will be in two protonated (non-ionized), tautomeric forms A1H and A2H;
- at pH = 5, approximately 50% of the substance will be in two protonated (non-ionized), tautomeric forms, A1H and A2H;
- at a pH value > 6.5, approximately 100% of the substance will be in one deprotonated (ionized) form of A-.
This is confirmed by the nature of the electronic absorption spectra of aqueous solutions of favipiravir. In the spectrum of favipiravir in a 0.1 M hydrochloric acid solution, there are two bands at the wavelengths of 322 nm and 365 nm, which correspond to the two tautomeric forms A1H and A2H. In the spectrum of favipiravir in 0.1 M sodium hydroxide solution, there is one band at a wavelength of 364 nm, which corresponds to one ionized form of A-.
At the stage of pharmaceutical development, these data on the acid-base properties of the Favipiravir API can be used in the development of production technology, the creation of quality control methods and their validation, as well as in the study of the solubility of the API and the dissolution profiles of the finished medicinal product.
Financial Inclusion through Islamic Microfinance: Empirical Evidence from Developing Countries
Authors: Syahrul Hidayat Muhammad , Mazidah Nurul , Setia Aksana Didik Supardana , Nurhayati
Published: November 2023

This study explores the important role played by Islamic microfinance in promoting financial inclusion in developing countries. Using empirical evidence, this research shows how Islamic microfinance institutions have helped in reducing poverty and improving the economic welfare of underprivileged communities. Through secondary data analysis and case studies, this research highlights how sharia economic principles such as the prohibition of riba (interest) and the emphasis on asset-based contracts have facilitated access to financial services for individuals previously underserved by conventional financial institutions. This research also discusses the challenges faced by the Islamic microfinance sector and provides recommendations for the future
Cartografias culturais da pandemia: uma análise das representações e práticas espaciais dos alunos do IFPR – União da Vitória
Authors: Calandro Thiago Luiz , Amaral Marcelo D'Ávila , Silva Gabriela Sena da
Published: November 2023

O presente trabalho de pesquisa tem como objetivo identificar e discutir as representações espaciais de práticas e discursos de 20 alunos do terceiro ano dos cursos técnicos em Informática e em Meio Ambiente integrados ao ensino médio do IFPR – União da Vitória/PR em lugares comuns a partir do contexto da pandemia da Covid-19. Aqui, o termo cartografia cultural se expressa como uma visão não ortogonal do espaço e feita por não cartógrafos, apresentando uma preocupação maior com as situações e os contextos espaço-temporais do que com a visão cartesiana do espaço. A metodologia de pesquisa é a análise documental e será considerada e aplicada nos registros produzidos pelos alunos voluntários. As análises dos resultados apontaram que, com as restrições sociais e sanitárias exigidas em virtude da pandemia da Covid-19, a relação dos alunos com aspectos e dimensões do espaço de vivência se alterou. Assim, a pandemia pode ser considerada uma acontecimento-evento para a sucessão cultural por alterar as durações do cotidiano escolar.