bluuebunny/crossref_metadata_2025 huggingface dataset:
Current Biologic Therapies for Severe Asthma and Real-World Data: Are Expectations Being Met?
Authors: Villamañán Elena , Laorden Daniel , Granda Paula , Sobrino Carmen , De Andrés Susana , Carpio Carlos , Domínguez-Ortega Javier , Romero David , Mariscal Pablo , De Las Vecillas Leticia , Quirce Santiago , Álvarez-Sala Rodolfo ,   on behalf of AsmaGrave-HULP Study
Published: November 2024

Advances in knowledge about clinical features, physiology, and underlying immunology are leading to targeted therapies and a new era of therapies. Biological treatments for severe asthma have changed the way this disease is managed, especially in patients who do not respond adequately to conventional treatments with corticosteroids and bronchodilators. These treatments block the action of different molecules involved in the immune response and in the inflammation of the airways, bronchoconstriction, bronchial hyperresponsiveness, and excessive mucus production. Currently, there are sufficient real-life data to corroborate the good results obtained in clinical trials by these type of drugs for severe asthma patients. Observational studies reveal their efficacy and safety, reducing exacerbations, leading to fewer emergency room visits and hospitalizations, and improving quality of life with better asthma control and better functional status.
Oncological and Functional Outcomes After Type III Cordectomy for Early Glottic Cancer (Tis, T1a): A Retrospective Study Based on Our 10-Year Experience
Authors: Lovati Eleonora , Genovese Elisabetta , Presutti Livio , Trebbi Marco , Pingani Luca , Galeazzi Gian Maria , Luppi Maria Pia , Alicandri-Ciufelli Matteo , Marchioni Daniele , Guarnaccia Maria Consolazione
Published: November 2024

Background: The recommended treatment for early glottic cancer is trans-oral laser microsurgery, with excellent oncological and functional outcomes. The aim of this study is to evaluate oncological and functional outcomes in patients who underwent monolateral type III laser cordectomy for early glottic cancer. Methods: A total of 104 patients were enrolled. Staging, histological type, grading, assessment of surgical margins, mean time of relapse, OS, DFS, and DSS were obtained. Maximum phonation time, GIRBAS score, shimmer, jitter, fundamental frequency, and Yanagihara score were evaluated. Patients were submitted to the VHI-10 questionnaire. Results: Correlations between patients with single recurrence and the anterior commissure involvement were analyzed, as well as correlations between patients with recurrence and the status of margins. Correlations between VHI-10 scores and anterior commissure involvement were analyzed. Conclusions: The recurrence rate was higher in patients with anterior commissure involvement. A significant inversely proportional association between DSS and assessment of surgical margins was observed. The distribution of VHI-10 scores differed significatively in patients with and without anterior commissure involvement. Vocal results reflected mild dysphonia.
Advances in Cardiac Imaging and Genetic Testing for Diagnosis and Risk Stratification in Cardiomyopathies: 2024 Update
Authors: Gasior Tomasz
Published: November 2024

Cardiomyopathies represent a diverse group of heart muscle diseases marked by structural and functional abnormalities that are not primarily caused by coronary artery disease. Recent advances in non-invasive imaging techniques, such as echocardiography, cardiac magnetic resonance, and computed tomography, have transformed diagnostic accuracy and risk stratification, reemphasizing the role of cardiac imaging in diagnosis, phenotyping, and management of these conditions. Genetic testing complements imaging by clarifying inheritance patterns, assessing sudden cardiac death risk, and informing therapeutic choices. Integrating imaging data, such as left ventricular wall thickness, fibrosis, and apical aneurysms, with genetic findings enhances decision-making for implantable cardioverter-defibrillators in high-risk patients. Emerging technologies like artificial intelligence, strain imaging, and molecular imaging, alongside genetic testing, hold the promise of further refining diagnosis and personalized treatment approaches. This article summarizes the current state and future perspectives of cardiac imaging and genetic testing for diagnosis and risk stratification in cardiomyopathies, offering practical insights for patients’ management.
A Cross-Sectional Evaluation of Disability in Inflammatory Bowel Disease Using IBD Disk in a Tertiary Center from Romania
Authors: Muru Oana-Maria , Pop Corina Silvia , Filip Petruța Violeta , Tiucă Nicoleta , Diaconu Laura Sorina
Published: November 2024

Background/Objectives: The management of inflammatory bowel disease (IBD) includes, besides the control of symptoms, the prevention of organ damage and the improvement of the overall disability. Methods: A single-centered, cross-sectional, non-interventional and population-based study was conducted between October 2023 and August 2024 in the Department of Internal Medicine 2 and Gastroenterology of Bucharest Emergency University Hospital to assess the disease disability and quality of life impact using IBD-disk and correlation with different parameters. Results: We included 112 patients; their mean age was 52.35 ± 16.67 years, with a disease duration of 114.9 ± 97.93 months. The majority of patients were represented by men (51.79%). We observed a strong correlation between the CDAI score and overall disability compared to the Mayo score for UC (p = 0.0068). Also, patients with CD and stenotic patterns, as well as the presence of extraintestinal complications, have associated high disability scores. Low hemoglobin levels are associated with high disability (p = 0.0164), while biological treatment is associated with low disability (p = 0.0481). Conclusions: IBD-disk can be used as a valuable tool to assess disability in patients with IBD, also in terms of the activity of the disease, but mostly in terms of the psychological burden of the disease.
Human Infertility and Reproductive Endocrinology
Authors: Grande Giuseppe
Published: November 2024

One of the biggest problems facing modern medicine is infertility [...]
Increased Variability in Lower Limb Muscle Activation Is Observed with Increasing Walking Speed in Fall-Risk Older Adults
Authors: Park Yongnam , Bae Youngsook
Published: November 2024

This study is a cross-sectional study and aims to determine the differences in lower limb muscle activation and variability at preferred, slow, and fast walking speeds according to age and fall risk. We divided 301 participants into groups based on fall risk (fall-risk vs. non-fall-risk). We measured muscle activation and its coefficients of variation (CV) for the rectus femoris (RF), biceps femoris (BF), tibialis anterior (TA), and medial gastrocnemius muscle (GCM) at speeds 20% slower, 20% faster, and 40% faster than the preferred speed (PS). When compared by fall risk, fall-risk older adults had significantly lower GCM activity and higher CVs of RF, BF, TA, and GCM in PS. With changes in gait speed, fall-risk older adults had significantly increased CVs of RF, BF, and GCM. Our findings provide new evidence that variability rather than muscle activity increases with walking speed in older adults at risk of falls, highlighting the importance of decreasing muscle activity variability in preventing fall risk.
Effects of Quartz Sand on the Electromagnetic Wave Absorption of Cementitious Materials
Authors: Li Chaoqun , Wang Zixiao , Shi Weizheng , Huang Ling , Xie Aming
Published: November 2024

The roles of dielectric materials in adjusting the electromagnetic wave (EMW) absorption performance of an EMW absorber are as crucial as the EMW absorbents. The commonly used cement-based materials, such as mortar, are typical composites of multiple dielectric materials, such as quartz sand and air in the pores. This study investigates the EMW-absorption performances within the frequency range of 2 GHz to 18 GHz of cement paste and mortar samples with different sand-to-cement ratios (S/C), water-to-cement ratios (W/C), and thicknesses. The bow-frame method is used to measure the EMW reflection loss (RL) curves of slab-like samples. The coaxial method is used to record the electromagnetic parameters of the sample powders, which are also used to calculate the EMW RL curves. The results prove that the EMW-absorption performances of a slab-like mortar sample are monotonically related to the S/C ratio and the actual air volume, which is closely related to the thickness.
Fouling and Chemical Cleaning Strategies for Submerged Ultrafiltration Membrane: Synchronized Bench-Scale, Full-Scale, and Engineering Tests
Authors: Zhu Xiwang , Fan Chengyue , Fang Yichen , Yu Wenqing , Xie Yawei , Liu Hongyuan
Published: November 2024

This study investigated membrane fouling issues associated with the operation of a submerged ultrafiltration membrane in a drinking water treatment plant (DWTP) and optimized the associated chemical cleaning strategies. By analyzing the surface components of the membrane foulant and the compositions of the membrane cleaning solution, the primary causes of membrane fouling were identified. Membrane fouling control strategies suitable for the DWTP were evaluated through chemical cleaning tests conducted for bench-scale, full-scale, and engineering cases. The results show that the membrane foulants were primarily composed of a mixture of inorganics and organics; the inorganics were mainly composed of Al and Si, while the organics were primarily humic acid (HA). Sodium citrate proved to be the most effective cleaning agent for inorganic fouling, which was mainly composed of Al, whereas sodium hypochlorite (NaClO) combined with sodium hydroxide (NaOH) showed the best removal efficiency for organic fouling, which predominantly consisted of HA and Si. However, sodium hypochlorite (NaClO) combined with sodium hydroxide (NaOH) showed the best removal efficiency for organic fouling and Si; organic fouling predominantly consisted of HA. Based on the bench-scale test results, flux recovery was verified in the full-scale system. Under a constant pressure of 30 kPa, the combined acid–alkali cleaning achieved the best flux recovery, restoring the flux from 22.8 L/(m2·h) to 66.75 L/(m2·h). In the engineering tests, combined acid–alkali cleaning yielded results consistent with those of the full-scale tests. In the practical engineering cleaning process, adopting a cleaning strategy of alkaline (NaClO + NaOH) cleaning followed by acidic (sodium citrate) cleaning can effectively solve the membrane fouling problem.
Revealing the Surface and In-Depth Operational Performances of Oxygen-Evolving Anode Coatings: A Guideline for the Synthesis of Inert Durable Anodes in Metal Electrowinning from Acid Solutions
Authors: Bošnjaković Jovana , Panić Vladimir , Stevanović Maja , Stopic Srecko , Stevanović Jasmina , Grgur Branimir , Šekularac Gavrilo
Published: November 2024

The electrochemical performances of an oxygen-evolving anode produced by the reactivation of waste Ti substrate by a typical IrO2-Ta2O5 coating are correlated to the textural (non)uniformities of the coating and its exhaustion state. Coating degradation is considered operational loss of the activity in a metal electrowinning process. It was found that (pseudo)capacitive performances can vary over the coating surface by 20–30% and depend on the type of dynamics of the input perturbation: constant through cyclic voltammetry (CV) or discontinuous time-dependent through electrochemical impedance spectroscopy (EIS). CV-EIS data correlation enabled profiling of the capacitive properties through the depth of a coating and over its surface. The correlation was confirmed by the findings for the analysis of coating activity for an oxygen evolution reaction, finally resulting in the reliable proposition of a mechanism for the operational loss of the anode. It was found that the less compact and thicker coating parts performed better and operated more efficiently, especially at lower operational current densities.
Laterally Excited Resonators Based on Single-Crystalline LiTaO3 Thin Film for High-Frequency Applications
Authors: Guan Chongrui , He Xingli
Published: November 2024

High-performance acoustic resonators based on single-crystalline piezoelectric thin films have great potential in wireless communication applications. This paper presents the modeling, fabrication, and characterization of laterally excited bulk resonators (XBARs) utilizing the suspended ultra-thin (~420 nm) LiTaO3 (LT, with 42° YX-cut) film. The finite element analysis (FEA) was performed to model the LT-based XBARs precisely and to gain further insight into the physical behaviors of the acoustic waves and the loss mechanisms. In addition, the temperature response of the devices was numerically calculated, showing relatively low temperature coefficients of frequency (TCF) of ~−38 ppm/K for the primary resonant mode. The LT-based XBARs were fabricated and characterized, which presents a multi-resonant mode over a wide frequency range (0.1~10 GHz). For the primary resonance around 4.1 GHz, the fabricated devices exhibited a high-quality factor (Bode-Q) ~ 600 and piezoelectric coupling (kt2) ~ 2.84%, while the higher-harmonic showed a greater value of kt2 ~ 3.49%. To lower the resonant frequency of the resonator, the thin SiO2 film (~20 nm) was sputtered on the suspended device, which created a frequency offset between the series and shunt resonators. Finally, a ladder-type narrow band filter employing five XBARs was developed and characterized. This work effectively demonstrates the performance and application potential of micro-acoustic resonators employing high-quality LT films.
Antibiotic-Producing Bacteria Collected from Seawater
Authors: Dashti Khadijah M. , Vali Leila , Almaraghi Norya , Ebrahim Hussain , Abul Hassan , Dashti Ali A.
Published: November 2024

Background: Microorganisms are a known source of antibiotics. The study aimed to identify and screen antibiotic-producing microbes isolated from seawater. Method: Three of the fifty (50) bacteria isolated from seawater showed positive for antibiotic activity. The antimicrobial activity of Pseudomonas guguanensis (KD1) was screened against the ESKAPE pathogens using agar-well diffusion assays. P. guguanensis (KD1) was selected for the fermentation and extraction of antimicrobial compounds using solvent extraction assays. Results: P. guguanensis (KD1) produced the highest antibacterial activity after 36 h of cultivation, inhibiting S. aureus, E. faecium, A. baumannii and E. cloacae. According to sensitization assay, K. pneumoniae was impermeable to all the cell-free supernatants of P. guguanensis (KD1). Using agar-well diffusion assays, ethyl acetate extracts from the supernatant recorded zones of inhibition against S. aureus, E. faecium, and E. cloacae, producing zones of 20.1 ± 0.432, 17.8 ± 0.121 and 16 ± 0.162 mm, respectively. Acetonitrile extract from the supernatant inhibited A. baumannii and S. aureus, forming zones of inhibition 18.2 ± 0.323 mm and 18 ± 0.234. The minimum inhibitory concentration and minimum bactericidal concentration recorded for the ethyl acetate extract and acetonitrile extract ranged from 1.56 to 6.25 mg/mL and 12.5–25 mg/mL, respectively. Conclusions: P. guguanensis (KD1) offers a potential source of antibiotics for infections caused by multidrug-resistant bacteria.
Semiconductor Nanomaterials for Optoelectronic Applications
Authors: Lo Ikai
Published: November 2024

Nanotechnology has been comprehensively investigated for more than 30 years [...]
The Synthesis of Granular ZSM-23 Zeolite with a High Degree of Crystallinity and a Micro-Meso-Macroporous Structure, and Its Use in the Hydroisomerization of n-Hexadecane
Authors: Travkina Olga S. , Serebrennikov Dmitry V. , Kuvatova Rezeda Z. , Khazipova Alfira N. , Filippova Nadezhda A. , Agliullin Marat R. , Kutepov Boris I.
Published: November 2024

This paper proposes a method for synthesizing granular ZSM-23 zeolite with a high degree of crystallinity and hierarchical porous structure. This method is based on crystallizing granules composed of powdered ZSM-23 zeolite and a specially prepared amorphous aluminosilicate. It has been shown that these granules have superior mechanical strength compared to granular zeolite-containing materials, which are made from a mixture of ZSM-23 zeolite crystals and Al2O3. It has been demonstrated that when 0.5% of Pt granular ZSM-23 zeolite is used, with a high degree of crystallinity and a hierarchical porous structure, it exhibits higher activity and selectivity in the hydroisomerization of n-hexadecane compared to a bifunctional catalyst, which is a mechanical mixture of ZSM-23 zeolite crystals and Al2O3, with the metal deposited on the granules.
Omega-3 Supplementation and Nutritional Status in Patients with Pancreatic Neoplasms: A Systematic Review
Authors: Pires Luciana , Salaroli Luciane , Podesta Olívia , Haraguchi Fabiano , Lopes-Júnior Luís
Published: November 2024

Objectives: The purpose of this study was to synthesize and evaluate the evidence regarding the effects of omega-3 supplementation on the nutritional status of pancreatic cancer patients. Methods: A systematic review of clinical trials was conducted, adhering to the PRISMA Statement. MEDLINE/PubMed, EMBASE, CENTRAL Cochrane, Scopus, and Web of Science databases were searched up to 31 December 2022 without restrictions on the publication date or language. Independent reviewers extracted data and assessed the risk of bias. The internal validity and risk of bias in randomized controlled trials (RCT) were assessed using the revised Cochrane risk of bias tool for randomized trials-RoB2, while the risk of bias in non-randomized intervention studies was evaluated using the ROBINS-I tool. Results: Eight studies met all the inclusion criteria and were analyzed. Five of them were RCT, with the majority (n = 4) classified as low risk of bias, and the three quasi-experiments were deemed to have a moderate risk of bias. Among the studies investigating the outcome of weight gain/maintenance, six reported statistically significant positive results (p < 0.05). Conclusions: In conclusion, the presented evidence indicates that omega-3 supplementation in pancreatic cancer patients is safe, well-tolerated, and beneficial, as it contributes to the stabilization or increase in body weight, as well as a reduction in inflammatory biomarkers.
Effects of Increasing Farmed Salmon Intake to the Recommended Fish-Intake Amounts on Lipid Profile in Young Women: An 8-Week Intervention Study
Authors: Utri-Khodadady Zofia , Głąbska Dominika
Published: November 2024

Background/Objectives: Habitual dietary changes that could help reduce the potential consequences of excessive body mass, such as hyperlipidemia and increased cardiovascular disease risk, are needed. The aim of this study is to assess the impact of a farmed-salmon-based dietary intervention on lipid profile parameters in young women with excessive body mass. Methods: The 8-week intervention involved 38 pair-matched women aged 18–30 years with excessive body weight defined as BMI ≥ 25.0 kg/m2. Participants were randomly assigned to the intervention (200 g of smoked salmon weekly) or the control group. Lipid profile parameters (total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglycerides (TAG)), as well as atherogenic indices (Atherogenic Index of Plasma (AIP), Atherogenic Coefficient (AC), Cholesterol Index (Cholindex), Castelli Risk Index 1 (CRI-1), Castelli Risk Index 2 (CRI-2) and the TAG/HDL ratio) were assessed before, during, and after the intervention. Results: At baseline, 47% of participants had at least one of the lipid profile parameters outside the recommended range. No statistically significant differences were observed in the TC, HDL, non-HDL, LDL, or TAG concentrations or in the various atherogenic indices between the intervention and the control group after the 8-week-long intervention. However, differences in the change of the LDL concentration were noted, with a decrease of 8.2 ± 20.7 mg/dL in the intervention group compared to an increase of 9.5 ± 20.0 mg/dL in the control group (p = 0.011), as well as in the change of the Cholindex for which a median decrease of 4.4 mg/dL was noted in the intervention group, while a median increase of 0.8 mg/dL in the control group was observed (p = 0.040). Additionally, across participants with a waist-to-height ratio (WHtR) greater than 0.5, an increase of 50.0 ± 68.3 mg/dL in the intervention group and a decrease of 8.6 ± 56.6 mg/dL in the control group was noted for the TAG concentration change (p = 0.040). Conclusions: Concerning the observed beneficial influence of increasing farmed salmon intake to the recommended fish-intake amounts on decreasing LDL and Cholindex in young women with excessive body weight after 8 weeks, it seems that such a diet alteration might be recommended for this group to decrease their risk of cardiovascular disease in the future. Nonetheless, regarding the diverse influence on TAG, further studies are needed to assess the influence of increasing the intake of fatty fish available on the market at present on human health.
Controlling Nutritional Status (CONUT) Score as Prognostic Indicator in Stage IV Gastric Cancer with Chronic Intestinal Failure
Authors: Matysiak Konrad , Hojdis Aleksandra , Szewczuk Magdalena
Published: November 2024

The management of chronic intestinal failure (CIF) secondary to advanced gastric cancer poses clinical challenges. This study explores the correlation between the Controlling Nutritional Status (CONUT) index and survival in patients with TNM stage IV gastric cancer on home parenteral nutrition (HPN). Methods: From 2015 to 2023, 410 patients (37% women, 63% men) with CIF due to advanced gastric cancer were assessed using CONUT scores, BMI, and biochemical tests. The Cox proportional hazards model was used to evaluate the impact of covariates on survival. Logistic regression categorized malnutrition levels by CONUT scores, with performance evaluated using precision, recall, and F1 scores. A p-value < 0.001 was statistically significant. Results: The CONUT scores were independent predictors of survival, with higher CONUT scores increasing mortality risk (HR = 2.073, 95% CI: 1.815–2.369, p < 0.001). The model achieved an overall accuracy of 71%, indicating correct classification for the majority of cases. Conclusions: CONUT scores are key predictors of survival in patients receiving HPN for CIF due to stage IV gastric cancer.
Acetoin Promotes Plant Growth and Alleviates Saline Stress by Activating Metabolic Pathways in Lettuce Seedlings
Authors: Zhou Chaowei , Shen Hui , Yan Shangbo , Ma Changyi , Leng Jing , Song Yu , Gao Nan
Published: November 2024

Acetoin is a volatile organic compound, which is a class of metabolites produced by plant growth-promoting rhizobacteria. The mechanisms underlying plant growth promotion by acetoin and its potential to induce saline stress tolerance in plants are poorly understood. Lettuce (Lactuca sativa L. var. ramosa Hort.) seedlings in hydronics and pots under non-saline or saline conditions were foliar-sprayed with 10 mL of 0 or 1 mg·mL−1 acetoin at 7 and 14 d after transplantation and harvested 7 d after the second spray. Shoots and roots of hydroponic lettuce seedlings were harvested at 6 and 24 h after treatment for RNA sequencing. Seedlings sprayed with acetoin showed more vigorous growth, with higher shoot and root biomass than those of the controls, in both hydronic and pot modes. The transcriptomic analysis revealed acetoin application resulted in 177 differentially expressed genes (39 upregulated and 138 downregulated) in shoots and 397 differentially expressed genes (112 upregulated and 285 downregulated) in roots. These DEGs, mainly involved in plant hormone signal transduction and the mitogen-activated protein kinase, have the potential to trigger plants’ responses to various environmental stimuli, including stress and developmental signals. Under saline conditions, acetoin-treated plants showed increased net leaf photosynthesis and activities of several defense enzymes, indicating that acetoin enhances both fundamental growth and the plant’s stress defenses, especially against salinity. In summary, acetoin appears to act through a complex interplay of genetic and biochemical mechanisms, influencing key signaling pathways and physiological processes that lead to improved growth and stress tolerance in lettuce seedlings.
The Sound Absorption Performance of Laser-Sintered Composite Biomimetic Wood Porous Structures
Authors: Zou Li , Zhang Aitian , Liu Zhenbo , Du Pengfei , Guo Yanling
Published: November 2024

This study investigates the development of biomimetic sound-absorbing components through laser sintering technology, drawing inspiration from wood’s natural porous structure. Using a pine wood powder/phenolic resin composite, various specimens were fabricated with different structural configurations (solid, fully porous, and varying straight-pore ratios) and cavity thicknesses. Sound absorption performance was evaluated using the impedance tube transfer function method. The effect of different composite structures, placement orientations, and cavity thicknesses on sound absorption performance was evaluated. The results demonstrate that solid laser-sintered samples exhibit inherent sound absorption properties due to microscopic pores, with absorption coefficients exceeding 0.234. The biomimetic wood-like structure, featuring multi-scale porosity at both microscopic and mesoscopic levels, shows enhanced broadband sound absorption, particularly in mid-high frequencies, with characteristic double-peak absorption curves. The study reveals that absorption performance can be optimized by adjusting structural parameters and thickness, enabling targeted frequency-specific sound absorption. This research establishes the feasibility of creating multi-frequency sound-absorbing materials using laser-sintered biomimetic wood structures, providing a foundation for future applications and development in acoustic engineering.
Investigation of Mechanical Properties and Oil Resistance of Hydrogenated-Butadiene-Acrylonitrile-Rubber-Based Composites Across Various Temperatures
Authors: Han Yu , Nie Jingkai , Zhu Zhanwei , Yin Hang , Shi Lei , Wang Shuai , Liu Xiaosheng , He Qiang
Published: November 2024

The influence of molecular structure (acrylonitrile content) and formulation (carbon black and plasticizer dosage) on the rheological and mechanical properties of HNBR composites was systematically studied, with further discussion on ozone resistance and swelling behavior in transformer oil. The results demonstrated that the curing characteristics and rheological behavior of HNBR composites are closely linked to acrylonitrile content, carbon black, and plasticizer levels. Plasticizers significantly reduced the degree of crosslinking and the Payne effect, while fillers had the opposite impact. Fillers increased the modulus at 100% and 200%, reducing elongation at break, whereas plasticizers enhanced elongation at break while lowering the modulus. The effects of fillers and plasticizers on tensile strength were relatively minor. Both exhibited different influences on mechanical properties at various aging temperatures. Compression set testing revealed that under a 125 °C hot air environment, the compression set was less than 30%, while at −30 °C in cold air, it exceeded 60%. In a 125 °C hot transformer oil environment, the compression set ranged between 30% and 60%. Oil resistance tests indicated that HNBR composites with higher acrylonitrile content showed lower mass change rates in transformer oil, with further reduction achieved by increasing the plasticizer or filler content. Due to their excellent performance and resistance to ozone cracking, HNBR composites have significant potential for applications in high-altitude power grids and military-grade rubber sealing products.
Modifying Bitumen with Recycled PET Plastics to Enhance Its Water Resistance and Strength Characteristics
Authors: Jexembayeva Assel , Konkanov Marat , Aruova Lyazat , Kirgizbayev Akpan , Zhaksylykova Lailya
Published: November 2024

This study investigates the modification of bituminous mixtures by varying percentages of PET particles (1%, 3%, 5%, 8%, 10%, and 12% PET). The following methods were employed to analyze the samples: the ring-and-ball softening point determination method (ASTM D36/D36M-14), the Fraass breaking point determination method (EN 12593: 2015), the elongation determination method (EN 13589: 2014), and the needle penetration depth determination method (EN 1426: 2015). Optimal bitumen/PET ratios were identified to obtain modified bituminous mixtures (MBMs) with enhanced operational characteristics (5% and 8% PET). The physical and mechanical properties of the investigated bitumen samples and PET were determined. A comparative analysis of the modified bituminous mixture samples based on their physical and mechanical properties was conducted. Microstructures of the surface of modified bituminous mixture samples with varying modifier contents were obtained. An X-ray structural analysis was performed on the samples of modified bituminous mixtures with varying PET contents. The dependencies of the moisture absorption rate on time were determined for the samples of modified bituminous mixtures with different modifier contents. The values of the stress intensity factor were determined based on the number of loading cycles in fatigue tests using three-point bending for the samples of modified bituminous mixtures with varying modifier contents.
Shaped by His Upbringing: Jesus’ Mission in Luke 4: 16–22 Aligned with Luke 2: 51–52 as a Paradigm for Youth Formation, Empowerment, and Social Engagement Today
Authors: Sciberras Paul
Published: November 2024

This paper examines the formative influence of Jesus’ upbringing in Nazareth, particularly as depicted in Luke 4: 16–22, alongside related passages such as Luke 2: 51–52. Through these accounts, this analysis seeks to elucidate the social, cultural, and spiritual dimensions of Jesus’ early life and their significance in shaping his mission and identity, as well as how his religious customs and community involvement can inspire contemporary youth by integrating the core pillars of faith, education, and family and empowering them to confront modern challenges with a holistic perspective inspired by Jesus’ mission. Methodologically, it should be taken for granted that a tendency to psychologise biblical characters—interpreting their actions or decisions as if they shared modern psychological frameworks—can lead to oversimplifications or misapplications. For example, Jesus’ obedience to his parents reflects a culture of strict family authority, contrasting with today’s focus on independence and self-expression in youth development. By examining key Greek terms such as tethramménos (from trépho: ‘having been brought up’) and katà tò eiōthòs autộ (‘as was his custom’) in v.16, this study emphasises Jesus’ strong connection to his faith and cultural heritage. His regular participation in synagogue life and his upbringing in a religious and familial context (see Luke 2: 51–52) were crucial in shaping his identity and preparing him for his transformative and transforming mission, according to the Isaianic prophecy (61: 1–2) he read on the same occasion. This paper argues that these early experiences, particularly his education within the Jewish tradition and his family’s role in nurturing his spiritual growth, were foundational for the holistic mission Jesus would later proclaim—a mission that sought spiritual, social, and physical liberation.
Material Flow Analysis: An Analytical Tool for Strategic Planning Towards a Zero-Waste Solution for End-of-Life Ballast Flows on a Track and Ballast Renewal Site (French Conventional Line)
Authors: Giboulot Olivier , Lemelin Emmanuel , Binetruy Christophe , Abriak Nor-Edine
Published: November 2024

The 27,000 km of railway track in France represents approximately 100 million tonnes of ballast. This ballast requires maintenance approximately every 7 years, screening and partial renewal every 20 years, and complete replacement every 40 years. Despite its shortcomings, ballast is still widely used on railways worldwide, as there is no better or more efficient solution currently available. In an effort to conserve resources, companies such as SNCF (French national railway company) are implementing initiatives to move towards zero waste. In order to achieve the goal of promoting the recycling and recovery of end-of-life material flows, it is necessary to develop specific studies and models for production, such as direct and reverse logistics systems. This article proposes a generic material flow analysis model applied to a track and ballast renewal site, aiming to fill a gap in the literature. It is based on data from eleven track and ballast renewal sites. A flow diagram generated by STAN software presents a detailed diagnosis of ballast inputs, outputs, and stocks, including data uncertainty. The distribution of the material flows through the model is characterized by transfer coefficients in various transformation processes. Furthermore, by varying the quantities in this model, it is possible to study different scenarios based on the current situation. This will facilitate the projection and analysis of future management strategies aimed at achieving zero waste and reducing the discharge of toxic substances based on specific performance indicators.
Optimal-Transport-Based Positive and Unlabeled Learning Method for Windshear Detection
Authors: Zhang Jie , Chan Pak-Wai , Ng Michael Kwok-Po
Published: November 2024

Windshear is a microscale meteorological phenomenon that can be dangerous to aircraft during the take-off and landing phases. Accurate windshear detection plays a significant role in air traffic control. In this paper, we aim to investigate a machine learning method for windshear detection based on previously collected wind velocity data and windshear records. Generally, the occurrence of windshear events are reported by pilots. However, due to the discontinuity of flight schedules, there are presumably many unreported windshear events when there is no flight, making it difficult to ensure that all the unreported events are all non-windshear events. Hence, one of the key issues for machine-learning-based windshear detection is determining how to correctly distinguish windshear cases from the unreported events. To address this issue, we propose to use a positive and unlabeled learning method in this paper to identify windshear events from unreported cases based on wind velocity data collected by Doppler light detection and ranging (LiDAR) plan position indicator (PPI) scans. An optimal-transport-based optimization model is proposed to distinguish whether a windshear event appears in a sample constructed by several LiDAR PPI scans. Then, a binary classifier is trained to determine whether a sample represents windshear. Numerical experiments based on the observational wind velocity data collected at the Hong Kong International Airport show that the proposed scheme can properly recognize potential windshear cases (windshear cases without pilot reports) and greatly improve windshear detection and prediction accuracy.
Single-Scene SAR Image Data Augmentation Based on SBR and GAN for Target Recognition
Authors: Feng Shangchen , Fu Xikai , Feng Yanlin , Lv Xiaolei
Published: November 2024

High-performance neural networks for synthetic aperture radar (SAR) automatic target recognition (ATR) often encounter the challenge of data scarcity. The lack of sufficient labeled SAR image datasets leads to the consideration of using simulated data to supplement the dataset. On the one hand, electromagnetic computation simulations provide high amplitude accuracy but are inefficient for large-scale datasets due to their complex computations and physical models. On the other hand, ray tracing simulations offer high geometric accuracy and computational efficiency but struggle with low amplitude correctness, hindering accurate numerical feature extraction. Furthermore, the emergence of generative adversarial networks (GANs) provides a way to generate simulated datasets, trying to balance computational efficiency with image quality. Nevertheless, the simulated SAR images generated based on random noise lack constraints, and it is also difficult to generate images that exceed the parameter conditions of the real image’s training set. Hence, it is essential to integrate physics-based simulation techniques into GANs to enhance the generalization ability of the imaging parameters. In this paper, we present the SingleScene-SAR Simulator, an efficient framework for SAR image simulation that operates under limited real SAR data. This simulator integrates rasterized shooting and bouncing rays (SBR) with cycle GAN, effectively achieving both amplitude correctness and geometric accuracy. The simulated images are appropriate for augmenting datasets in target recognition networks. Firstly, the SingleScene-SAR Simulator employs a rasterized SBR algorithm to generate radar cross section (RCS) images of target models. Secondly, a specific training pattern for cycle GAN is established to translate noisy RCS images into simulated SAR images that closely resemble real ones. Finally, these simulated images are utilized for data augmentation. Experimental results based on the constructed dataset show that with only one scene SAR image containing 30 target chips, the SingleScene-SAR Simulator can efficiently produce simulated SAR images that exhibit high similarity in both spatial and statistical distributions compared with real images. By employing simulated SAR images for data augmentation, the accuracy of target recognition networks can be consistently and significantly enhanced.
Valorization and Bioremediation of Digestate from Anaerobic Co-Digestion of Giant Reed (Arundo donax L.) and Cattle Wastewater Using Microalgae
Authors: Silva Guilherme Henrique da , Renato Natália dos Santos , Borges Alisson Carraro , Martins Marcio Arêdes , Reis Alberto José Delgado dos , Otenio Marcelo Henrique
Published: November 2024

Anaerobic digestion followed by microalgal cultivation is considered a promising renewable alternative for the production of biomethane with reduced effluent generation, thus lowering the environmental impact. In this arrangement, in addition to generating energy, the microalgae act by potentiating the refinement of the effluents generated via anaerobic digestion (digestates). In this study, the microalga Tetradesmus obliquus was cultivated in photobioreactors with the final digestate resulting from the co-digestion of Arundo donax L. plant biomass and cattle wastewater. The biotechnological route used was efficient, and the biogas production ranged from 50.20 to 94.69 mL gVS−1. The first-order kinetic model with variable dependence (FOMT) provided the best fit for the biogas production data. In the microalgal post-treatment, the removal values ranged from 81.5 to 93.8% for the chemical oxygen demand, 92.0 to 95.3% for NH4+-N, and 41.7 to 83.3% for PO43− after 26 days. The macromolecular composition of the algal biomass reached lipid contents ranging from 33.4 to 42.7%. Thus, the proposed process mediated by microalgae can be considered promising for the bioremediation and recovery of effluents produced by agriculture through the use of microalgal biomass for bioproduct production.
Zero Plastic Drive: A Comprehensive Review on Unveiling Innovative Sustainable Solutions for a Circular Plastics Economy
Authors: Shamsuddoha Mohammad , Kashem Mohammad Abul
Published: November 2024

Living in a society where plastic has become a necessity, the over-reliance on these materials is quite disturbing as they have social and economic effects, especially in waste disposal and resource management. Such issues have introduced the circular plastics economy (CPE), which aims to eliminate plastic waste by focusing on reducing, recycling, and reusing (3R) and designing biodegradable plastic products. Owing to these facts, a systematic literature review (SLR) was conducted to analyze the existing literature on circular economy principles and plastic waste management systems in terms of 3R initiatives. Also, this study showcases the CPE by investigating how it is possible to manage plastic within a circular economy instead of a linear system. Additionally, system dynamics modeling (SDM) was applied to examine the inter-relationships between key elements such as plastic production, waste generation, recycling rates, and regulatory actions, along with the cognizance phase of waste diversion and advanced sorting technology to minimize landfill dependency and environmental pollution initiatives, including producer responsibility programs and zero-landfill targets. This study accumulated that zero waste strategies, such as plastic circularity, national waste management, and high-quality recycling, have achieved recycling rates ranging from 30% to 81% across various countries, significantly reducing plastic waste and enhancing resource efficiency. However, the added strategies in countries that are related to policy-driven initiatives can prospectively be useful for increasing recycling capacity to eliminate plastic waste in landfills, promoting a circular economy and sustainable waste management practices. This study also involved the critical stakeholders of the CPE who will make the utilization of plastic waste a reality. Ultimately, this research contributes to the fast-growing knowledge base on plastic waste management by presenting an interdisciplinary framework based on model synthesis and mathematical modeling, which is crucial for decision-makers, industries, and researchers.
Development and Assessment of a Carpooling Applied System: Perspective of Users from Public-Education Sector
Authors: Delgado-Fernández Vicente , Rey-Merchán María del Carmen , Rosa Manuela Pires
Published: November 2024

The heavy reliance on private cars is linked not only to harmful environmental impacts, such as gas emissions and global warming, but also to other issues like traffic congestion, road infrastructure maintenance, and the limited availability of parking spaces—significant concerns in many cities. To address these challenges, carpooling has been shown to be an effective solution, as it directly reduces emissions, alleviates congestion, and mitigates the environmental effects of transportation.The aim of this research is to enhance the understanding of carpooling in our society. To achieve this, a carpooling initiative among teachers for their commuting journeys was developed and implemented, followed by an evaluation of the system by a panel of experts. The results showed a 31.9% reduction in the number of cars on the road among participants, with a total of 109,080 km saved based on the reduced number of vehicles.The primary motivation for participants to adopt carpooling was fuel savings, while the reduction of physical fatigue from driving was identified as the second most important factor. Although some barriers to participation were identified, their impact was generally lower than that of the perceived benefits. These findings suggest that carpooling programs should focus on optimizing matching conditions and addressing individual concerns to promote wider adoption.
Electrokinetics-Based Phosphorus Management in Soils and Sewage Sludge
Authors: Abou-Shady Ahmed , Osman Mohamed A. , El-Araby Heba , Khalil Ali Kh A. , Kotp Yousra H.
Published: November 2024

Phosphorus (P) is a key component that limits plant growth. P is a limited resource; hence, effective P management is needed to increase plant P consumption from the soil and reduce P input levels through fertilization. In light of these difficulties, the goal of this review is to investigate the role of soil electrokinetics (SEKs)—a physicochemical approach—as the main approach in our in-depth analysis of publication history across six P-management research search engines to ensure sustainable management. This review covers the management of P using the SEKs from a number of perspectives, such as P injection in soil to improve bioremediation efficiency; P specific and synergistic separation from other related elements; increasing plant P availability and reusing it as fertilizer; and P removal from soil and sewage sludge. In terms of P adsorption, after seven days on kaolin, no organic P adsorption was observed, while inorganic P adsorbed to a maximum of 73% after six days. This implies that in low-permeability soils, the organic P source can be a practical source of P during in situ bioremediation. With the use of chemical additives, the specific and synergistic separation of P from/with other elements was made possible. When compared to the region near the cathode, P availability for the plant was higher in the vicinity of the anode electrode. P can be recycled and used as fertilizer. The iron electrodes result in a noticeably greater removal of phosphate than titanium electrodes. Further research is required to offer a technical solution for the proper handling of P, as there has been little research on P management from many perspectives.
Geoheritage Degradation Risk Assessment: Methodologies and Insights
Authors: Vandelli Vittoria , Selmi Lidia , Faccini Francesco , Ferrando Andrea , Coratza Paola
Published: November 2024

Over the past 25 years, geoconservation studies and interest in geoheritage have grown significantly. However, the assessment of degradation risks associated with geosites remains less explored. This aspect is crucial for the effective management and conservation of geosites, which face pressure from natural and human factors. In many countries, geosites are at risk of degradation or loss due to the lack of a systematic inventory and inadequate management. Therefore, evaluating and monitoring degradation risks is a priority for the scientific community. Common investigation schemes and approaches for recognizing and preventing threats to geosites are still lacking. This paper presents the first systematic literature review on degradation risk and related terms. Through an extensive search of widely used literature databases, 130 papers were selected and analyzed. The findings highlight a growing focus on quantitative approaches for the assessment of geoheritage degradation risk, with most research conducted at local scales, while identifying climate change as an underexplored yet critical factor. Future priorities include refining spatial and temporal scales, understanding degradation processes, and fostering global collaboration to improve conservation strategies.
The Impact of Vaccinations Against Respiratory Infections on the Prognosis in Heart Failure Patients
Authors: Jankowiak Berenika , Wleklik Marta , Rosiek-Biegus Marta
Published: November 2024

Heart failure (HF) affects 64 million people worldwide and is one of the most prevalent causes of hospitalization in adults. Infection is believed to be one of the potential triggers that may facilitate HF decompensation and the need for hospitalization. Therefore, it seems crucial to safeguard against such a situation. Vaccinations seem to be a very reasonable option. However, this remains an underutilized solution among HF patients. This review investigates the impact of available vaccinations, including influenza, COVID-19, pneumococcal, and RSV, on prognosis in specific HF populations only, as there are pathophysiological reasons to believe that this population of patients may benefit the most from the intervention. It will provide information about the safety profile of these vaccines and summarize the available evidence on their impact on hard clinical outcomes. In summary, this article will discuss the impact of preventive vaccinations against seasonal infections in the HF population.