bluuebunny/crossref_metadata_2025 huggingface dataset:
Disc Large Homolog 1 Is Critical for Early T Cell Receptor Micro Cluster Formation and Activation in Human T Cells
Authors: Guha June , Chari Raj
Published: December 2021

T cell activation by antigen involves multiple sequential steps, including T cell receptor-microcluster TCR-(MC) formation, immunological synapse formation, and phosphorylation of mediators downstream of the TCR. The adaptor protein, Disc Large Homolog 1 (DLG1), is known to regulate proximal TCR signaling and, in turn, T cell activation, acting as a molecular chaperone that organizes specific kinases downstream of antigen recognition. In this study, we used knockdown and knockout technologies in human primary T cells and a human T cell line to demonstrate the role of DLG1 in proximal T cell signaling. High-end confocal microscopy was used for pictorial representation of T cell micro-clusters and colocalization studies. From all these studies, we could demonstrate that DLG1 functions even earlier than immunological synapse formation, to regulate T cell activation by promoting TCR-MC formation. Moreover, we found that DLG1 can act as a bridge between the TCR-ζ chain and ZAP70 while inhibiting binding of the phosphatase SHP1 to TCR-ζ. Together, these effects drive dysregulation of T cell activation in DLG1-deficient T cells. Overall, the activation and survival status of T cell is a critical determinant of effective vaccine response, and DLG1-mediated T cell signaling events can be a driving factor for improving vaccine-designing strategies.
Influence of Prior Influenza Vaccination on Current Influenza Vaccine Effectiveness in Children Aged 1 to 5 Years
Authors: Matsumoto Kazuhiro , Fukushima Wakaba , Morikawa Saeko , Fujioka Masashi , Matsushita Tohru , Kubota Megumi , Yagi Yoshina , Takasaki Yoshio , Shindo Shizuo , Yamashita Yuji , Yokoyama Takato , Kiyomatsu Yumi , Hiroi Satoshi , Nakata Keiko , Maeda Akiko , Kondo Kyoko , Ito Kazuya , Kase Tetsuo , Ohfuji Satoko , Hirota Yoshio
Published: December 2021

Background: Although annual influenza vaccination is an important strategy used to prevent influenza-related morbidity and mortality, some studies have reported the negative influence of prior vaccination on vaccine effectiveness (VE) for current seasons. Currently, the influence of prior vaccination is not conclusive, especially in children. Methods: We evaluated the association between current-season VE and prior season vaccination using a test-negative design in children aged 1–5 years presenting at nine outpatient clinics in Japan during the 2016/17 and 2017/18 influenza seasons. Children with influenza-like illness were enrolled prospectively and tested for influenza using real-time RT-PCR. Their recent vaccination history was categorized into six groups according to current vaccination doses (0/1/2) and prior vaccination status (unvaccinated = 0 doses/vaccinated = 1 dose or 2 doses): (1) 0 doses in the current season and unvaccinated in prior seasons (reference group); (2) 0 doses in the current season and vaccinated in a prior season; (3) 1 dose in the current season and unvaccinated in a prior season; (4) 1 dose in the current season and vaccinated in a prior season; (5) 2 doses in the current season and unvaccinated in a prior season, and (6) 2 doses in the current season and vaccinated in a prior season. Results: A total of 799 cases and 1196 controls were analyzed. The median age of the subjects was 3 years, and the proportion of males was 54%. Overall, the vaccination rates (any vaccination in the current season) in the cases and controls were 36% and 53%, respectively. The VEs of the groups were: (2) 29% (95% confidence interval: −25% to 59%); (3) 53% (6% to 76%); (4) 70% (45% to 83%); (5) 56% (32% to 72%), and (6) 61% (42% to 73%). The one- and two-dose VEs of the current season were significant regardless of prior vaccination status. The results did not differ when stratified by influenza subtype/lineage. Conclusion: Prior vaccination did not attenuate the current-season VE in children aged 1 to 5 years, supporting the annual vaccination strategy.
Knowledge, Perception, and Willingness towards Immunization among Bangladeshi Population during COVID-19 Vaccine Rolling Period
Authors: Bari Md. Sazzadul , Hossain Md. Jamal , Ahmmed Foyez , Sarker Md. Moklesur Rahman , Khandokar Labony , Chaithy Aperajita Paul , Aziz Farina , Mitra Saikat , Emran Talha Bin , Islam Md. Saiful , Islam Md. Rabiul , Mohamed Isa Naina
Published: December 2021

Vaccine willingness among the mass populace, as well as their proper knowledge and perception regarding vaccines and the vaccination process, may contribute extensively towards attaining their anticipated vaccination rates. The current study endeavored to ascertain the Bangladeshi population’s knowledge, perception, and willingness towards COVID-19 vaccination. Relevant information was collected from 1201 adults aged 18 years or older by employing an online-based survey from 1 to 30 July 2021. Descriptive statistics, the chi-square (χ2) test, and a binary logistic regression analysis were applied in order to compare the extent of knowledge and perception prevalent among different demographic groups and correlate such prevalence with respective vaccine willingness. The participants expressed mean (± standard deviation) knowledge and perception scores of 6.48 ± 1.13 out of 8 and 5.37 ± 1.22 out of 7, respectively. A multivariate analysis confirmed the significant association (p < 0.05) of gender, age, and family income with the knowledge score, whereas age and knowledge level significantly influenced perception. Current living area, family income, and age were considerable contributors to COVID-19 vaccine willingness. Overall vaccine willingness was found to be significantly curtailed by inadequate knowledge (AOR 0.514, CI 95% 0.401–0.658, p < 0.001) and perception (AOR 0.710, CI 95% 0.548–0.920, p = 0.010) among the participants. All of the concerned authorities’ efforts are warranted in order to improve public understanding, perception, and inclination towards vaccination.
Introducing a Calculator for the Environmental and Financial Potential of Drain Water Heat Recovery in Commercial Kitchens
Authors: Schestak Isabel , Spriet Jan , Styles David , Williams A. Prysor
Published: December 2021

Food service providers like restaurants, cafes, or canteens are of economic importance worldwide, but also contribute to environmental impacts through water and energy consumption. Drain water heat recovery from commercial kitchens, using a heat exchanger, has shown large potential to decarbonise hot water use across food services, but is rarely deployed. This work translates previous findings on the technical feasibility and heat recovery potential for commercial kitchens into a publicly available calculator. It facilitates decision-making towards recovery and reuse of the freely available heat in kitchen drains by estimating both financial costs and payback time, as well as environmental burdens associated with the installation and environmental savings from avoided energy consumption. Environmental burdens and savings include, but are not limited to, carbon emissions. Further, the tool highlights key aspects of the technical implementation to understand installation requirements. The tool is freely available and could contribute to the uptake of heat recovery in the food service sector, ideally in conjunction with policy support through financial incentives or subsidies.
SOGAZ-Med experience in conducting training for employees of a medical organization in the city of Ivanovo
Authors: Chumenko Nikolay Leonidovich
Published: December 2021

In the context of the ongoing COVID-19 epidemic, the issues of maintaining medical workers’ psychological resistance to stress and preventing their professional burnout are becoming urgent. SOGAZ-Med regularly holds events dedicated to patient orientation and conflict resolution.
Improving the system of measures to support industrial development in Russia
Authors: Dubovik M. V. , Salakhova N. Sh. , Sizova D. A.
Published: December 2021

Currently, it is not individual enterprises that compete in the global market of industrial goods, but value chains. Within their framework, technological and production interfaces, diversification of demand markets, and optimization of business processes contribute to a sharp increase in the competitiveness of enterprises. The existing measures to support the development of industry do not confirm their effectiveness based on the results of work. To improve the system of support measures, the following steps are proposed: value chains should become the main tool for implementing the state’s industrial policy, measures for technological re-equipment based on intersectoral interaction of enterprises of high-tech and medium-tech industries should be implemented, as well as development institutions alternative to the banking sector should be formed. When implementing the proposed state support measures, the conditions for the sustainable development of the manufacturing industry in Russia are formed.
Overcoming imbalances in the provision of natural resources for the development of the World Economy: maintaining a minor role of Russian TNCs
Authors: Kuznetsov Alexey Vladimirovich
Published: December 2021

The article shows that although the threat of rapid depletion of mineral resources in the world is largely exaggerated, imbalances in their distribution and consumption are gradually increasing. On the one hand, globalization intensifies the competition of countries for resources, as the global development of recent decades shows. On the other hand, globalization mitigates imbalances through foreign trade and direct investment. The article examines the role of Russian investor companies in these processes. The research is based on corporate materials, official statistics and the most authoritative sources of industry information. The contribution of Russian oil and gas TNCs, companies specializing in the construction and operation of nuclear power plants and hydroelectric power plants, as well as leading investors in the field of non-ferrous metal industry was studied. A distinctive feature of Russian TNCs is the limited geography of their foreign business, especially in the countries of the global South. Usually we can see the preference of a narrow circle of countries which had long history of good political relations with Russia. At the same time, reliance on purely economic considerations is less pronounced than that of leading Western competitors. As a result, external shocks (whether political cataclysms in individual countries in the case of the oil and gas sector or sharp fluctuations in the international conjuncture in the case of non-ferrous metal industry) can greatly affect the scale of foreign activity of Russian TNCs. For the time being, it is more likely that we can still talk about the initial stages of internationalization of Russian business, which has little effect on the nature of global development with its investment activity. The article also shows that since in the future the scarcity of land and water resources will increase in the global economy, additional opportunities will open up for Russian companies to strengthen our country’s international positions. However, so far the activity of Russian TNCs is not observed there because it is limited mainly by the increase in grain exports to developing countries.
The Global Environmental Agenda of 2021 and the tasks of sustainable energy-ecological development and cooperation between Japan and countries Southeast Asia
Authors: Mishchenko Yana Vadimovna
Published: December 2021

The article discusses the main results of two major international summits held in October-November 2021, the key topics of which were the issues of the global fight against climate change and environmental protection. The decisions taken at these conferences, with the broad participation of world leaders, reflect the fundamental trends of the global environmental agenda. Within the framework of this agenda, Japan and the countries of Southeast Asia are building their modern energy and environmental cooperation. In this context, the article examines the main urgent tasks of energy-environmental interaction and sustainable development of Japan and the states of Southeast Asia. These countries are located in the Asia-Pacific region, which remains until now the main emitter of greenhouse gases in the world. However, the indicators of environmental pollution by Japan and the Southeast Asian countries are relatively not so high, compared to some other states in the region and the world. The article discusses the most relevant and significant examples of bilateral and multilateral cooperation between these countries in areas related to curbing global warming and climate protection. It has been revealed that with all the efforts made, since the 1990s, the indicators of reducing harmful emissions into the atmosphere in Japan remain modest and even lag behind some of the Western countries. The Southeast Asian countries show a serious attitude to the development of renewable energy, but their intention to abandon coal still raises some doubts about the methods of implementing this ambitious plan. In particular, it is currently not entirely clear whether these countries are preparing to make a full-fledged "energy transition" in the coming decades, or whether they just intend to replace their coal-fired thermal power plants with gas ones.
Estudio de factibilidad para un parque acuático en el cantón Manta, Ecuador
Authors: Basurto Bravo Isabel Yaqueline , Buste Moreira Gabriela Dolores
Published: December 2021

El objetivo de esta investigación es determinar la factibilidad de un parque acuático en el cantón Manta, la metodología utilizada inicia con un diagnóstico situacional que describe las características físicas y demográficas del cantón; seguido de un análisis estratégico del sector turístico. Procediendo con un estudio de mercado, donde se analizó la oferta, demanda y competencia, mediante encuesta aplicada al turismo interno para identificar los gustos y preferencias; se aplicó una ficha de observación a los establecimientos de recreación, obteniendo el perfil competitivo. Consecutivamente se realizó un análisis técnico con el que se determinó el tamaño y la distribución e ingeniería del proyecto, se evaluaron los impactos físicos-ambientales a través de la matriz de Leopold. Finalmente se procedió a efectuar un análisis de factibilidad económica-financiera mediante varios indicadores, los cuales dieron como resultado la viabilidad del proyecto para el parque acuático en el cantón Manta.

 

Palabras clave: factibilidad; estudio de mercado; producto turístico; impacto ambiental; parque acuático.
Herramienta para determinar costos-producción de dulces “Asociación General de Artesanos” cantón Rocafuerte, Ecuador
Authors: Mendoza Vera Cristina , Velásquez Gutiérrez Martha Tatiana
Published: December 2021

Los procesos de producción en el campo artesanal se dan de forma empírica, tradicionalmente sin conocimiento previo de técnicas o instrumentos que faciliten el trabajo como fuente de desarrollo socio económico, por ello; la presente investigación tiene como objetivo proponer una herramienta para determinar los costos de producción de dulces en la Asociación General de Artesanos del cantón Rocafuerte. La metodología utilizada fue de carácter no experimental, siendo los métodos inductivo-deductivo, descriptivo, histórico y de campo, con técnicas como encuestas, entrevistas y guías de observación. Esta investigación se delimitó mediante encuestas aplicadas a los miembros de la Asociación, también se realizó una entrevista al presidente de la organización, dando como resultado un instrumento donde se detallan los métodos y pasos a seguir para ejecutar el trabajo diario de los artesanos artífices; plasmados en tablas de Excel para una mayor comprensión.

 

Palabras clave: instrumento; costes; mano de obra; materia prima.
Revisión Teórica sobre la innovación en el desarrollo del turismo sostenible y su influencia socio ambiental.
Authors: Ruiz Cedeño Angélica , Villar Lopez Lidia , Ávila Zambrano José Leonardo
Published: December 2021

En el presente artículo tiene como objetivo analizar la importancia de la innovación en el desarrollo del turismo sostenible y su influencia en el desarrollo socioeconómico. La metodología utilizada para la investigación consistió en un análisis teórico-conceptual en primer lugar de los principales aspectos teóricos sobre sostenibilidad e innovación y, en segundo lugar, la innovación en el desarrollo del turismo sostenible y su influencia socio ambiental en el Ecuador. De los resultados obtenidos se visualizó que la innovación del turismo sostenible se convierte en una herramienta clave para el desarrollo del sector turístico ya que, por medio de esta, se podrán tomar acciones correctivas para que este sea sostenible. Para ello se necesita que las políticas de desarrollo sustentable se materialicen como un conjunto de estrategias, planes y procesos a escala mundial, regional, nacional y local.

 

Palabras clave: I+D; sostenibilidad; socio ambiental; turismo sostenible
El emprendimiento en América Latina: Un análisis de su etimología, tipología y proceso
Authors: Ruiz Cedeño Sebastiana Del Monserrate , Palacios Dueñas Abad Eduardo
Published: December 2021

El presente artículo tiene como objetivo analizar el emprendimiento en América Latina. Se inicia explicando bajo distintas teorías, el fenómeno del emprendimiento, sus tipologías y etapas; finalizando con un análisis del emprendimiento en Latinoamérica. Metodológicamente, el estudio es descriptivo; y se utilizaron fuentes bibliográficas y estadísticas documentales del Banco Mundial. La teoría describe el emprendimiento como un proceso que crea valor agregado, donde se asumen riesgos financieros, sociales y psicológicos, a fin de obtener beneficios económicos y satisfacción personal. Los resultados muestran que en Latinoamérica se identifica como debilidad la escasez de innovación. Se concluye que, aunque el emprendimiento es un fenómeno consolidado, falta consenso acerca del concepto “emprender”; además, existe una brecha grande en términos de innovación entre países latinoamericanos y los países y regiones comparables, no sólo en el ámbito de la Innovación y Desarrollo, sino también en el contexto de la innovación de productos y procesos.
 
Palabras clave: emprendimiento; emprender; tipos de Emprendimiento; proceso de emprendimiento; América Latina.
 
Abstract
This article aims to analyze entrepreneurship in Latin America. It begins by explaining under different theories, the phenomenon of entrepreneurship, its typologies and stages; ending with figures of entrepreneurship in Latin America. Methodologically, the study is descriptive; and bibliographic sources and documentary statistics from the World Bank were used. The theory describes entrepreneurship as a process that creates added value, where financial, social and psychological risks are assumed, in order to obtain economic benefits and personal satisfaction. The results show that in Latin America the lack of innovation is identified as weakness. It is concluded that, although entrepreneurship is a consolidated phenomenon, there is a lack of consensus about the concept of “entrepreneurship”; In addition, there is a large gap in terms of innovation between latin American countries and comparable countries and regions, not only in the field of Innovation and Development, but also in the context of product and process innovation.
 
Keywords: consumption; business; perception; Amazon; infusion; health; marketing mix.
Perspectiva de consumo y marketing mix para una infusión de ortiga con naranja en Pastaza
Authors: Enriquez Miguel Ángel , Pérez Quintana Manuel Lázaro
Published: December 2021

El emprendimiento estudiantil a nivel universitario dentro de carreras de producción es uno de los ejes importantes en el desarrollo de las regiones, este tiene que ir de la mano de estrategias de distribución tratando de formar emprendedores y administradores de sus propios emprendimientos, es por eso que este trabajo mide el nivel de consumo de infusiones de plantas aromáticas en la Ciudad del Puyo, Ecuador; definidas con un 78 % de consumo. La metodología que se aplico es inductiva con un enfoque cuantitativo, de perspectiva empresarial, con un alcance de la investigación exploratoria y descriptiva, mediante el levantamiento de una herramienta (encuesta) para medir la percepción. Como conclusión se definió que la frecuencia de consumo de infusiones se determina que se lo hace de 2 a 3 veces por semana con el 59 %, definidas que el 44 % de consumidores lo hacen por temas de salud, el 56 % lo consumen en la noche, tomando en cuenta la importancia de consumo de plantas con el 56 %, en relación al gusto de las especies se puede observar que el 24 % prefiere la hierba luisa, el 23 % la Jamaica y el 21 % la guayusa. En relación al apoyo de este emprendimiento estudiantil tenemos un 83 % de personas que apoyarían nuestra propuesta de infusión, se definió un plan de marketing mix basado en los resultados y adaptado a la situación de la ciudad.
 
Palabras clave: consumo; empresarial; percepción; amazónico; infusión; salud; marketing mix.
 
Abstract
Student entrepreneurship at the university level within production careers is one of the important axes in the development of the regions, this has to go hand in hand with distribution strategies trying to train entrepreneurs and managers of their own ventures, that is why This work measures the level of consumption of infusions of aromatic swamps in the City of Puyo, Ecuador; defined with a 78% consumption. The methodology that is applied is inductive with a quantitative approach, from a business perspective, with a scope of exploratory and descriptive research, by raising a tool (survey) to measure perception. In conclusion we define that the frequency of infusion consumption is determined to be done 2 to 3 times per week with 59%, defined that 44% of consumers do it for health issues, 56% consume it at night, taking into account the importance of consumption of plants with 56%, in relation to the taste of the species it can be observed that 24% prefer the lemon verbena, 23% the Jamaica and 21% the guayusa. In relation to the support of this student entrepreneurship we have 83% of people who would support our infusion proposal, a marketing mix plan based on the results and adapted to the city situation was defined.
 
Keywords: consumption; business; perception; Amazon; infusion; health; marketing mix.
Muebles artesanales a base de neumáticos reciclados: Análisis de viabilidad para su elaboración y comercialización
Authors: Merino Mauricio Ivan , Merino Jorge Luis , Quimbiulco Daniela Nicole , Karam Karina
Published: December 2021

La contaminación por abandono de neumáticos en basureros es una amenaza contra el medio ambiente. En Ecuador se desechan 2,4 millones al año, la mayoría son depositados en basureros al aire libre. El objetivo de esta investigación fue determinar la viabilidad de implementar una empresa de elaboración y venta de muebles artesanales basados en llantas recicladas. Se utilizó la metodología basada en el análisis cualitativo y cuantitativo del cliente; descripción de oportunidad de negocio; y evaluación financiera. El mercado potencial son hombres y mujeres entre 20 y 64 años de clase social media, la estructura organizacional estará basada en una estructura lineal - funcional compuesta por tres áreas específicas. El negocio requiere una inversión inicial de $ 62.909,68. El proyecto refleja un valor actual neto y tasa interna de retorno positivo, y tiempo de recuperación menor a los 5 años, lo cual refleja que el negocio es viable y rentable.
 
Palabras clave: producción; inversión; creación de empresas; economía de la empresa; marketing.
 
Abstract
Pollution from tire abandonment in garbage dumps is a threat against the environment, in Ecuador 2.4 million are disposed annually, most are deposited in outdoor garbage dumps. The objective of this research was to determine the feasibility of implementing a company that produces and sells handmade furniture based on recycled tires. The methodology based on the qualitative and quantitative analysis of the client was used; business opportunity description; and financial evaluation. The potential market is men and women between 20 and 64 years of middle social class, the organizational structure will be based on a linear-functional structure composed of three specific areas. The business requires an initial investment of $ 62.909, 68. The project reflects a positive net present value and internal rate of return, and recovery time less than 5 years, which reflects that the business is viable and profitable.
 
Keywords: production; investment; creation of companies; business economics; marketing.
Sistema de capacitación en educación ambiental para el desarrollo sostenible del turismo en Villa Clara, Cuba
Authors: Martínez de la Vega Vivian , Moré Estupiñán Mavel , Naranjo Llupart María Rosa
Published: December 2021

El presente artículo muestra el diseño del Sistema de Capacitación en Educación Ambiental para el Desarrollo Sostenible del turismo en Villa Clara, Cuba. Lo sustentan el estudio de periodización y la sistematización de experiencias de capacitación en Educación Ambiental para el Desarrollo Sostenible, EApDS, en el turismo y contiene propuestas de sistema de categorías y subcategorías de diagnóstico y evaluación, y el diseño de materiales de apoyo, instrumentos y herramientas complementarias. Diseñado por la metodología de Lorences, el sistema lo componen cuatro subsistemas: diagnóstico, organización y planificación, formas organizativas y, evaluación, control y divulgación. El aporte del sistema emana de la identificación y estudio de las condiciones y objetos independientes en la capacitación, en interconexión y sinergia, expresadas en la relación entre las formas organizativas construidas con el tema de cambio climático como eje transversal y en la relación entre los subsistemas y acciones que lo integran y cuya estructuración sustituye el empirismo y espontaneidad precedente en la capacitación en Educación Ambiental para el Desarrollo Sostenible del turismo en Villa Clara, con impacto significativo en la mejora del desempeño ambiental del sector en el territorio..Palabras clave: sistema de capacitación; educación ambiental; sostenibilidad; categorías; diagnóstico; turismo.AbstractPresently article shows up the design of the System of Qualification in Environmental Education for the Sustainable Development of the tourism in Villa Clara, Cuba. They sustain it the periodization study and the systematizing of qualification experiences in Environmental Education for the Sustainable Development in the tourism and it contains proposals of system of categories and diagnosis subcategories and evaluation, and the design of support materials, instruments and complementary tools. Designed by the methodology of Lorences, the System composes it four subsystems (diagnosis, organization and planning, organizational forms and evaluation, control and popularization. The contribution of the System emanates of the identification and study of the conditions and independent objects in the qualification, in interconnection and synergy, expressed in the relationship among the organizational built forms with the topic of climatic change as traverse axis and in the relationship among the subsystems and actions that integrate it and whose structuring substitutes the empiricism and precedent spontaneity in the qualification in Environmental Education for the Sustainable Development of the tourism in Villa Clara, with significant impact in the improvement of the environmental acting of the sector in the territory.Keywords: training system; environmental education; sustainability; categories; diagnosis; tourism.
Estimación de la demanda de bebidas no alcohólicas en Ecuador
Authors: Orellana Bravo Mercy Raquel , Segovia Sarmiento Joselin Katerine , Sarmiento Juan Pablo
Published: December 2021

Con el objetivo de explorar el potencial de un impuesto a las bebidas azucaradas como medida de salud pública en Ecuador, se estiman las elasticidades precio propia, precio-cruzada e ingreso de la demanda de bebidas no alcohólicas a nivel de hogar. Utilizando un Sistema Casi Ideal de Demanda Cuadrática (QUAIDS), se encuentra que, contrario al consumo de bebidas soft, el consumo de gaseosas es elástico. Estos resultados revelaron ser independientes del nivel de ingreso del hogar. Además, se halló una relación de sustitución entre las bebidas gaseosas y los lácteos. El gravamen de gaseosas, por tanto, podría disminuir su consumo y dirigirlo hacia bebidas más saludables.
 
Palabras clave: Elasticidad de la demanda; bebidas azucaradas; impuesto.
 
ABSTRACT
This paper explores the potential effects of a tax on sugar-sweetened beverages as a public health policy in Ecuador by estimating the own, cross-price and income elasticities of non-alcoholic beverages at household level. We estimated a Quadratic Almost Ideal Demand System (QUAIDS) and found that, contrary to soft drinks, the consumption of soda is elastic. This revealed to be independent of the household income level. It was also found a substitution relationship between soda drinks and dairy drinks. Thus, taxation of soda drinks could decrease its consumption and direct it to healthier alternatives.
 
Keywords: Elasticity of demand; sugar-sweetened beverages; tax.
Impacto de las certificaciones sociales y ambientales sobre la responsabilidad social y empresarial de la empresa Atunera Manabita Marbelize S.A
Authors: Pinargote Intriago Génesis Liliana , Vélez Vélez Silenne Dayanna , Zambrano Zambrano María Inés , Santos Mendoza José Vicente
Published: December 2021

La responsabilidad social de las empresas y la gestión ambiental ha surgido rápidamente en los últimos años, esto puede ser atribuido a los consumidores que son cada día más exigentes y preocupados con el ecosistema, cuestionando no solamente la calidad de los productos sino exigiendo una calidad social y ambiental demostrable. La presente investigación tiene como objetivo analizar el impacto de las certificaciones sociales y ambientales sobre la responsabilidad social y empresarial de la empresa atunera manabita Marbelize S.A. La metodología fue de carácter no experimental, basado en una investigación descriptiva y explorativa, con técnicas de Análisis documental y bibliográfico, observación y entrevista aplicada a las diversas áreas relacionadas como Gerencia, Producción y Sistema de Gestión Integrada, dando como resultado el inicio de acciones de concientización sobre la importancia del cuidado ambiental para la sociedad en general y la empresa atunera.

 

Palabras clave: certificaciones; impacto; responsabilidad social

 

ABSTRACT

 

The social responsibility of companies and environmental management has emerged rapidly in recent years, this can be attributed to consumers who are increasingly demanding and concerned with the ecosystem, questioning not only the quality of the products but also demanding social quality. and demonstrable environmental. The objective of this research is to analyze the impact of social and environmental certifications on the social and business responsibility of the manabita tuna company Marbelize S.A. The methodology was non-experimental, based on a descriptive and exploratory research with techniques of documentary and bibliographic analysis, observation and interview applied to the various related areas such as management, production and integrated management system, resulting in the initiation of actions of raising awareness about the importance of environmental care for society in general and the tuna company.

 

Keywords: certifications; impact; social responsibility
Análisis económico financiero del hotel cabañas balandra de la ciudad de Manta, 2017-2018
Authors: Toala Mendoza Susy Tatiana , Toala Mendoza Rossana Dolores , Zambrano Farías José Iván , Valarezo Molina María José
Published: December 2021

La hotelería es una rama del turismo que abarca los servicios de alojamiento en diversos establecimientos, para lo cual se realizó un análisis al informe económico y financiero del Hotel Cabañas Balandra correspondiente al año 2017 y 2018 encaminado a la toma de decisiones. Esta empresa hotelera arroja resultados económicos que permiten conocer que ha existido deficiencia en la administración de sus recursos, a pesar que ese encuentra posesionado como uno de los mejores hoteles a nivel nacional. Para este estudio se utilizó como técnica la revisión bibliográfica de las definiciones esenciales para comprender la temática, método analítico y deductivo. Investigación de carácter cuantitativa porque se revisó estados financieros proporcionados por la Superintendencia de Compañías. Se aplicaron indicadores financieros: liquidez, endeudamiento, rentabilidad y actividad. Los mismos que demuestran una pequeña falencia en la liquidez en sus últimos años, el nivel de endeudamiento, patrimonio estable y rentabilidad equilibrada.

 

Palabras clave: contabilidad; auditoría; indicadores financieros; regulación.

 

ABSTRACT

The hotel industry is a branch of tourism that covers accommodation services in various establishments, for which an analysis was carried out on the economic and financial report of the Hotel Cabañas Balandra corresponding to the year 2017 and 2018 aimed at decision-making. This hotel company produces economic results that allow us to know that there has been a deficiency in the administration of its resources, despite the fact that it is positioned as one of the best hotels nationwide. For this study, the bibliographic review of the essential definitions to understand the subject, analytical and deductive method was used as a technique. Quantitative investigation because financial statements provided by the Superintendency of Companies were reviewed. Financial indicators were applied: liquidity, indebtedness, profitability and activity. The same ones that show a small deficiency in liquidity in their last years, the level of indebtedness, stable equity and balanced profitability.

 

Keywords: accounting; auditing; financial indicators; regulation.
Diagnóstico de la logística de las microempresas de la Amazonia ecuatoriana, adecuación matemática
Authors: Acosta Iglesias Dagoberto , Sablón cossío Neyfe , Acevedo Suárez José Antonio , Gómez Acosta Martha Ines
Published: December 2021

Caracterizar el estado de la logística constituye un soporte para trazar estrategias de desarrollo, tanto a nivel del sector empresarial como en la formación del potencial humano. El objetivo del artículo es demostrar cómo la utilización de los modelos de referencia de la logística y su adecuación matemática permite caracterizar el estado de la temática con sus particularidades en las microempresas en el contexto ecuatoriano. Se utilizan encuestas, el análisis y la síntesis, y la estadística para el diagnóstico. El resultado principal es la caracterización del estado de la logística en una muestra de empresas que es estadísticamente significativa. Como conclusión fundamental se obtuvo que los modelos de referencia desarrollados constituyen instrumentos de gran utilidad y validez para caracterizar el estado de la gestión logística en las condiciones de las empresas de la amazonia ecuatoriana, así como una guía para trazar estrategias para su desarrollo.

 

Palabras clave: logística, micro empresas, índice, gestión, modelo.

 

ABSTRACT

 

Characterizing the state of logistics constitutes a support to draw development strategies, both at the level of the business sector and in the training of human potential. The objective of the article is to demonstrate how the use of the logistics reference models and their mathematical adequacy allows characterizing the state of the subject with its particularities in micro-enterprises in the Ecuadorian context. Surveys, analysis and synthesis, and statistics are used for diagnosis. The main result is the characterization of the state of logistics in a sample of companies that is statistically significant. As a fundamental conclusion, it was obtained that the reference models developed constitute highly useful and valid instruments to characterize the state of logistics management in the conditions of companies in the Ecuadorian Amazon, as well as a guide to draw strategies for their developing.Keywords: logistics, micro enterpris-es, index, management, model.

 

Keywords: logistics, micro companies, index.
Empleo de indicadores para la mejora y sostenibilidad de las relaciones entre actores del alojamiento turístico en Trinidad
Authors: Yglesias Palmero Javier , Álvarez Cepero Kenia
Published: December 2021

La investigación se centra en elaborar un instrumento estratégico basado en indicadores de sostenibilidad turística, que contribuya a potenciar las relaciones colaborativas entre actores del alojamiento turístico de la ciudad patrimonial de Trinidad y lograr su sostenibilidad en el tiempo. La metodología empleada toma como referencia el procedimiento para el diagnóstico de la cooperación público–privada con enfoque estratégico, desarrollándose tres de sus cuatro fases. Se realiza además el mapeo de actores clave a fin de identificar los principales intereses asociativos que estos presentan en la ciudad. Los resultados obtenidos en el diagnóstico dan paso a la confección de un sistema de indicadores de sostenibilidad turística que permitirá mejorar las relaciones entre actores turísticos al tiempo que favorecerá la adopción de políticas públicas, su seguimiento y el establecimiento de estrategias para promover la participación responsable de los actores con intereses en el destino.

 

Palabras clave: Instrumento estratégico, colaboración, intereses asociativos, sostenibilidad turística.
La revista ECA Sinergia, rasgos distintivos y contexto histórico: aplicación de análisis métrico a su producción científica
Authors: Pinargote Anchundia Karla Analía , Sánchez Rivera María Teresa
Published: December 2021

A once años de su creación, la revista ECA Sinergia de la Universidad Técnica de Manabí se ha convertido en referente de las revistas del área disciplinar de ciencias administrativas, contables y económicas de mayor alcance y relevancia dentro de las universidades del Ecuador. El objetivo de esta investigación es caracterizar la revista y la realización de un análisis métrico en su producción científica, para lo que se utilizó la plataforma Google Académico, prestando atención al quinquenio (2016-2020). La metodología empleada para esta investigación es de carácter descriptivo – retrospectivo con observación directa a la revista objeto de estudio, así como su indexación en Google académico, para lo que se utilizó el método de análisis documental. Este estudio tiene un enfoque cuanti-cualitativo aplicando indicadores métricos a su producción en el periodo antes mencionado. Los resultados obtenidos en Google Académico permitieron delinear acciones e intervenciones a futuro, para lograr una mayor visibilidad de la revista en internet y un mejor posicionamiento de temas y autores.

 

Palabras clave: Producción científica, infometría, visibilidad, revistas indexadas.
Pengaruh Media Sosial terhadap Efikasi Keputusan Perjalanan Generasi Z dalam Memilih Destinasi Wisata di Jabodetabek
Authors: Alvionita Sisilia , Sutanto Eveline Gaby , Ayuningtyas Natasha Dyah , Wati Nyoman Krisna , Dewantara Made Handijaya
Published: December 2021

This study aims to determine the differences in social electronic word-of-mouth and travel motivation for Generation Z who are living in the Jabodetabek area. This research was conducted because it had never been done by previous researchers. The data collection used is by using a survey through Google Forms and literature studies from various journals. This study uses a quantitative approach by analyzing data through the IBM SPSS system. The results showed that there was a positive and significant relationship that the efficacy of generation Z travel decisions in choosing tourist destinations in the Jabodetabek area was influenced by the existence of the social electronic word of mouth and travel motivation. However, the differences in social electronic word-of-mouth and travel motivation among Generation Z who live in the Jabodetabek area are not homogeneous. Therefore, the calculation of the efficacy of their travel decisions also cannot be equated. The goals and motivations for the journey of Generation Z who live in Jakarta are not necessarily the same as Generation Z who live in other regions.
Konsep Protokol Kesehatan Wisata Edukasi Pada Daya Tarik Wisata Yayasan Tukad Bindu selama masa Pandemi Covid-19
Authors: I Gusti Ngurah Pertu Agung  , Ni Made Rai Kristina  , Pranata Darma I Gusti Ketut Indra , Krisdayanthi Astrid , Nirmalayani Ida Anuraga
Published: December 2021

Educational tourism as one of the development sectors of tourism is based on the community's need for educational variations. Educational tourism is suitable to be developed in locations that have limited locations and are in areas with residents. Tukad Bindu, as one of the densely populated areas in Denpasar, has the potential to develop educational tourism. The fast flow of the river becomes an attraction and strength in the tourism development needed by the local community. The learning model and the introduction of caring for nature can be applied to the tourist attraction of Tukad Bindu. In its development, the arrival of Covid-19 also affected the visit to the tourist attraction of Tukad Bindu which was seen in a drastic decrease in domestic tourists for almost 8 months. Strategic steps are needed in adapting the covid-19 virus so that the tourist attraction of Tukad Bindu can still run. This study aims to obtain a standard health protocol that can be done in entering the area of Tukad Bindu tourist attraction using a qualitative descriptive method. The results of the research can be used in application during the Covid-19 pandemic, so that people can still visit the tourist attraction of Tukad Bindu by following the applicable protocol.
Estimation of direct and maternal genetic parameters for weaning weight in Hungarian Simmental cattle
Authors: Ajasa Afees Abiola , Füller Imre , Vágó Barnabás , Komlósi István , Posta János
Published: December 2021

The aim of the current research was to estimate variance components and genetic parameters of weaning weight in Hungarian Simmental cattle. Weaning weight records were obtained from the Association of Hungarian Simmental Breeders. The dataset comprised of 44,278 animals born from 1975 to 2020. The data was analyzed using the restricted maximum likelihood methodology of the Wombat software. We fitted a total of six models to the weaning weight data of Hungarian Simmental cattle. Models ranged from a simple model with animals as the only random effect to a model that had maternal environmental effects as additional random effects as well as direct maternal genetic covariance. Fixed effects in the model comprised of herd, birth year, calving order and sex. Likelihood ratio test was used to determine the best fit model for the data. Results indicated that allowing for direct-maternal genetic covariance increases the direct and maternal effect dramatically. The best fit model had direct and maternal genetic effects as the only random effect with non-zero direct-maternal genetic correlation. Direct heritability, maternal heritability and direct maternal correlation of the best fit model was 0.57, 0.16 and -0.78 respectively. The result indicates that problem of (co-)sampling variation occurs when attempting to partition additive genetic variance into direct and maternal components.
Effect of arginine, putrescine and spermidine on the polyamine, proline and chlorophyll content of tobacco (Nicotiana tabacum L.)
Authors: Mendel Ákos , Kovács László , Kiss Erzsébet
Published: December 2021

Polyamines, such as spermidine (Spd) spermine (Spm) and their direct precursor, the diamine putrescine (Put) are vital and essential aliphatic amines which are also present in plants. Although ethylene and polyamines are also involved in fruit ripening, the genes coding them must also take part in other biosynthetic pathways. In the ethylene and polyamines play an important role in development of salt stress tolerance, and in responses for biotic and abiotic stresses. Exogenous application of all three main polyamines (Put, Spd, Spm) increase salt tolerance of plants, but, accordingly to previous experiments, spermidine has the main effect on the enhancement of salt tolerance. Nicotiana tabacum L. plants were grown in vitro on MS medium, the treatments were as follows: arginine (150 mg l-1), putrescine (10 mg l-1), spermidine (10 mg l-1). Proline, chlorophyll a, b and polyamine contents were measured. The obtained results show that the arginine decarboxylase and the spermidine synthase genes involved in polyamine metabolism, cannot be enhanced by exogenous addition of their precursor molecules. On the contrary, the spermine synthase gene has a positive effect to the lower-class forms of polyamines.
Abnormal Aggregation of Invasive Cancer Cells Induced by Collective Polarization and ECM-Mediated Mechanical Coupling in Coculture Systems
Authors: Wang Xiaochen , Chen Shaohua , Nan Hanqing , Liu Ruchuan , Ding Yu , Song Kena , Shuai Jianwei , Fan Qihui , Zheng Yu , Ye Fangfu , Jiao Yang , Liu Liyu
Published: December 2021

Studies on pattern formation in coculture cell systems can provide insights into many physiological and pathological processes. Here, we investigate how the extracellular matrix (ECM) may influence the patterning in coculture systems. The model coculture system we use is composed of highly motile invasive breast cancer cells, initially mixed with inert nonmetastatic cells on a 2D substrate and covered with a Matrigel layer introduced to mimic ECM. We observe that the invasive cells exhibit persistent centripetal motion and yield abnormal aggregation, rather than random spreading, due to a “collective pulling” effect resulting from ECM-mediated transmission of active contractile forces generated by the polarized migration of the invasive cells along the vertical direction. The mechanism we report may open a new window for the understanding of biological processes that involve multiple types of cells.
Highly Stable Nonhydroxyl Antisolvent Polymer Dielectric: A New Strategy towards High-Performance Low-Temperature Solution-Processed Ultraflexible Organic Transistors for Skin-Inspired Electronics
Authors: Zhang Mingxin , Zhang Cong , Yang Yahan , Ren Hang , Zhang Junmo , Zhao Xiaoli , Tong Yanhong , Tang Qingxin , Liu Yichun
Published: December 2021

Scarcity of the antisolvent polymer dielectrics and their poor stability have significantly prevented solution-processed ultraflexible organic transistors from low-temperature, large-scale production for applications in low-cost skin-inspired electronics. Here, we present a novel low-temperature solution-processed PEI-EP polymer dielectric with dramatically enhanced thermal stability, humidity stability, and frequency stability compared with the conventional PVA/c-PVA and c-PVP dielectrics, by incorporating polyethyleneimine PEI as crosslinking sites in nonhydroxyl epoxy EP. The PEI-EP dielectric requires a very low process temperature as low as 70°C and simultaneously possesses the high initial decomposition temperature (340°C) and glass transition temperature (230°C), humidity-resistant dielectric properties, and frequency-independent capacitance. Integrated into the solution-processed C8-BTBT thin-film transistors, the PEI-EP dielectric enables the device stable operation in air within 2 months and in high-humidity environment from 20 to 100% without significant performance degradation. The PEI-EP dielectric transistor array also presents weak hysteresis transfer characteristics, excellent electrical performance with 100% operation rate, high mobility up to 7.98 cm
2
 V
-1
 s
-1
(1 Hz) and average mobility as high as 5.3 cm
2
 V
-1
 s
-1
(1 Hz), excellent flexibility with the normal operation at the bending radius down to 0.003 mm, and foldable and crumpling-resistant capability. These results reveal the great potential of PEI-EP polymer as dielectric of low-temperature solution-processed ultraflexible organic transistors and open a new strategy for the development and applications of next-generation low-cost skin electronics.