bluuebunny/crossref_metadata_2025 huggingface dataset:
Metaphors are embodied otherwise they would not be metaphors
Authors: Torres-Martínez Sergio
Published: November 2023

In an interesting paper, Casasanto and Gijssels (2015) introduce a skeptical view of recent studies into the embodied character of metaphorical source domains. According to the authors, there cannot be conclusive evidence on the matter thus far, since, for a metaphor to be embodied, specific simulations must be modality-specific and not simply restricted to modality-specific activity brain areas. In line with this, I argue that metaphors reflect a connection between perception, memory, and consciousness (embodied extended mind). The Embodied Extended Mind Theory (EEMT) introduced in this paper is indebted to Active Inference (AIF), a process theory for the comprehension of intelligent agency. EEMT defends the idea that language bears traces of nonlinguistic, bodily acquired information that reflects biological processes of energy exchange and conservation. Therefore, it is assumed that what makes a metaphor embodied is not only the relation between a source domain and a target domain in ad hoc regions in the brain, but the alignment of multiple independent systems during the (re)construction of events. Central to this is the idea that humans use stored perceptual maps, the combination of which permits us to manipulate concepts as part of complex event partitioning.Keywords: Active Inference, conceptual metaphor, Embodied Extended Mind Theory, embodiment, modal-amodal representationResumenEn un interesante artículo, Casasanto y Gijssels (2015) presentan una perspectiva escéptica sobre los estudios recientes sobre el carácter encarnado de los dominios fuente metafóricos. Según los autores, hasta ahora no puede haber evidencia concluyente sobre el asunto, ya que, para que una metáfora sea encarnada, las simulaciones asociadas deben ser específicas de la modalidad y no simplemente restringidas a áreas cerebrales asociadas con la modalidad en cuestión. En consonancia con esto, argumento que las metáforas reflejan una conexión entre la percepción, la memoria y la conciencia (mente extendida encarnada). La Teoría de la Mente Extendida Encarnada (por sus siglas en inglés, EEMT) introducida en este artículo se basa en la Inferencia Activa (AIF), una teoría de procesos para la comprensión de la acción inteligente. La EEMT defiende la idea de que el lenguaje conserva rastros de información no lingüística y corporal que refleja procesos biológicos de intercambio y conservación de energía. Por lo tanto, se asume que lo que hace que una metáfora sea encarnada no es solo la relación entre un dominio fuente y un dominio objetivo en regiones ad hoc del cerebro, sino la alineación de múltiples sistemas independientes durante la (re)construcción de eventos. En el centro de esta formulación está la idea de que los humanos utilizan mapas perceptuales, cuya combinación nos permite manipular conceptos como parte de la partición de eventos complejos.Palabras clave: Inferencia Activa, metáfora conceptual, Teoría de la Mente Extendida Encarnada, cognición encarnada, representación modal-amodal.
Immunological correlates of suicidality among adolescents with internalizing symptoms
Authors: Roske Chloe , Schwartz Joshua , Nguyen Tram N.B. , Erulker Ava , Nie Kai , Xie Hui , Kim-Schulze Seunghee , Tobe Russell H. , Mowrey Wenzhu , Gabbay Vilma
Published: November 2023

Background: Suicide is the second leading cause of death in adolescents and young adults in the United States. Well-established risk factors for suicide are depression and past suicide attempts. People experiencing suicidality may represent a distinct neurobiological subgroup. Converging evidence has implicated inflammation in depression. Here we sought to investigate relationships between suicidality and immune markers in youth experiencing diverse mood and anxiety symptoms. We hypothesized that adolescents with suicidality would exhibit a unique immune signature. Methods: Adolescents underwent semi-structured interviews and completed self-reported measures to assess psychopathology, including suicidality. Fasting blood samples were collected, cultured with and without lipopolysaccharide (LPS) to stimulate an inflammatory response, and analyzed for 41 immune analytes. To assess how immune function related to suicidality categorically and dimensionally, we conducted group comparisons and correlations while controlling for multiple comparisons using false discovery rate (FDR). To further uncover subtle immune-suicidality relationships, we employed a data-driven approach using factor analysis to extract major immune factors, each of which was subsequently correlated with suicidality measures.Results: Among 126 participants, 29 were healthy controls and 97 participants had psychopathology; within the clinical group, 57 experienced suicidality. Three immune analytes differed between suicidal and non-suicidal adolescents in the LPS condition: Flt-3L (pFDR = 0.0246), GM-CSF (pFDR = 0.0246), and IFN-γ (pFDR = 0.0246). These analytes were negatively correlated with the Beck Scale for Suicide Ideation (BSSI): Flt-3L (ρ = −0.19, p = 0.04); GM-CSF (ρ = −0.26, p = 0.004); IFN-γ (ρ =−0.33, p = 0.0003). GM-CSF also negatively correlated with number of suicide attempts (ρ = −0.39, p = 0.003). Factor analysis revealed further associations between immune factors, derived from full 41-analyte panels, and suicidality across all sample culture conditions. Conclusions: Peripheral immune function may be distinctly altered in adolescent suicidality. Future work should examine immune-suicidality relationships longitudinally.
Opening up or not? Exploring motives, considerations and needs of students and staff of a Dutch university regarding the decision to disclose their mental health issues to inform decision aid development
Authors: Severijns Yil , Zijlstra Daniëlle , Brouwers Sanne Elisabetha Maria , den Uil Femke Maria , Vancauwenbergh Véronique , Gültzow Thomas
Published: November 2023

Mental health disclosure decisions can be difficult, especially within universities. University students and staff might benefit from decision support. Therefore, semi-structured interviews were conducted with staff (n=10) and students (n=10), including participants who decided to (not) disclose. The participants were asked to complete a questionnaire including the SURE test. Subsequently, they were interviewed about the decision to disclose and their needs regarding a disclosure decision aid. Data from the SURE test was analyzed based on descriptives, interviews were analyzed using the Framework–method. Most students (n=9) decided not to disclose, whereas most staff (n=8) did. Both students and staff described advantages and disadvantages of disclosing. Advantages included support, relief, understanding, and safety, but there were also risks, such as stigmatization and career concerns. Not disclosing can prevent unwanted questions but can also lead to misunderstandings. In short, disclosing offers opportunities and risks. Regarding decision support, both students and staff preferred a brief online tool. Both students and staff encounter challenges when it comes to deciding whether to disclose their mental health status. A decision aid can serve as a valuable tool to assist them in making informed decisions and preparing for potential conversations related to mental health disclosure.
Vers une sémiotique sadienne
Authors: Torres-Martínez Sergio
Published: November 2023

This study addresses how the work of the Marquis de Sade intersects with the developments of Wittgensteinian language games, i.e., language practices associated with communication in a given context. Firstly, the identification of the rule (as an organic element of a language practice) and the role of Peircean abduction in its application reveal that, for Sade, "doing the same thing" (i.e., following the rule) enables him to create a semiotic system to justify a bourgeois privilege ideology. Conceived in this way, the author's rule becomes an iconic experience of hyper-visibility (based on the frontality of sexuality) when applied by the reader (potential participant) to new language games. In this sense, the language games proposed by Sade aim to transcend the confines of the book to justify the (im)moral illusions of the author, keystones of his entire body of work.Keywords: abduction; rule of abduction; rule; Sade; Peirce; WittgensteinRésuméLa présente étude aborde la question de savoir comment l’œuvre du Marquis de Sade reste sur les développements des jeux du langage wittgensteniens, c’est-à-dire des pratiques langagières associées à la communication dans un contexte donné. Tout d’abord, une identification de la règle (en tant qu’élément organique d’une pratique langagière), et du rôle de l’abduction peircienne pour son application, montre que pour Sade « faire la même chose » (c’est-à-dire suivre la règle) lui permet de créer un système sémiotique pour justifier une idéologie du privilège bourgeois. Ainsi conçue, la règle d’auteur devient expérience iconique d’hypervisibilité (fondée sur la frontalité de la sexualité) lorsqu’elle est appliquée par le lecteur (participant potentiel) à des nouveaux jeux du langage. En ce sens, les jeux du langage proposés par Sade visent à franchir les rets du livre pour justifier les illusions (im)morales de l’auteur, clés de voûte de toute son œuvre.Mots-clés : abduction ; règle d’abduction ; règle ; Sade ; Peirce ; WittgensteinResumenEste estudio aborda cómo la obra del Marqués de Sade se entrelaza con los desarrollos de los juegos de lenguaje wittgensteinianos, es decir, prácticas lingüísticas asociadas con la comunicación en un contexto dado. En primer lugar, la identificación de la regla (como un elemento orgánico de una práctica lingüística) y el papel de la abducción peirceana en su aplicación revelan que, para Sade, "hacer lo mismo" (es decir, seguir la regla) le permite crear un sistema semiótico para justificar una ideología de privilegio burgués. Concebida de esta manera, la regla del autor se convierte en una experiencia icónica de hiper-visibilidad (basada en la frontalidad de la sexualidad) cuando es aplicada por el lector (potencial participante) a nuevos juegos de lenguaje. En este sentido, los juegos de lenguaje propuestos por Sade buscan trascender los límites del libro para justificar las ilusiones (in)morales del autor, piedras angulares de toda su obra.Palabras clave: abducción; regla de abducción; regla; Sade; Peirce; Wittgenstein
Reinforcement learning increasingly shapes memory specificity from childhood to adulthood
Authors: Nussenbaum Kate , Hartley Catherine A.
Published: November 2023

In some contexts, abstract stimulus representations can effectively promote the pursuit of reward, whereas in others, more detailed representations are needed to guide choice. Here, using a novel reinforcement-learning task, we asked how children, adolescents, and adults flexibly adjust the specificity of the representations used for learning based on experienced reward statistics, as well as how the specificity of these learning representations influences subsequent memory. Across two experiments (total N = 224), we found that children, adolescents, and adults flexibly up- and down-weighted more detailed versus broader stimulus representations, depending on the reward structure of the environment. The representations used for learning shaped mnemonic specificity; placing greater weight on detailed representations during value-guided learning enhanced subsequent memory for stimulus details, while placing greater weight on broader, categorical representations enhanced memory only for categorical information. Moreover, the relation between learning and memory strengthened with age; relative to adults, children demonstrated reduced coupling between the specificity of the representations used for value-based choice and the specificity of their subsequent memories. Our work demonstrates that from early in life, reward shapes the granularity with which the world is partitioned, which in turn exerts an increasing influence on how experiences are remembered into adulthood.
Mindful gratitude practice reduces prejudice at high levels of collective narcissism
Authors: Golec Agnieszka , Keenan Oliver , Ziegler Matthias , Mazurkiewicz Magdalena Anna , Wahl Julia , Ciesielski Paweł , Sedikides Constantine , Nalberczak-Skóra Maria
Published: November 2023

This research tested the hypothesis that mindful-gratitude practice attenuates the robust association between collective narcissism and prejudice. In between-subjects Study 1 (nationally representative sample of 569 Polish adults, 313 women), 10 minutes of mindful-gratitude practice—compared to mindful-attention practice and control—did not decrease prejudice (anti-Semitism), but weakened the positive link between collective narcissism and prejudice. In preregistered randomized-controlled-trial Study 2 (convenience sample of 219 Polish adults, 168 women), a 6-week mobile-app supported training in daily mindful-gratitude practice decreased prejudice (anti-Semitism, sexism, homophobia, anti-immigrant sentiment) and its link with collective narcissism, compared to a wait-list control. The hypothesis-consistent results emphasize the social relevance of mindful-gratitude practice, a time- and cost-effective intervention.
Embracing sleep onset complexity
Authors: Lacaux Célia , Strauss Mélanie , Bekinschtein Tristan , Oudiette Delphine
Published: November 2023

Sleep is crucial for many vital functions and is extensively studied. In contrast, the sleep onset period, often portrayed as a mere prelude to sleep, has been largely overlooked and remains poorly characterised. However, a recent series of studies has reignited interest in this transitional period, shedding light on its neural mechanisms, cognitive dynamics, and clinical implications. This review synthesises the existing knowledge on the sleep onset period in humans. We first examine the current definition of the sleep onset period and its limits, considering the dynamic and complex electrophysiological changes that accompany the descent to sleep. We then describe how internal and external processing interplay during the wake-to-sleep transition. Finally, we discuss the putative cognitive benefits of the sleep onset period, its scientific value, and identify novel directions to better diagnose sleep onset disorders.
Cultura emocional en los procesos de colectivización del cuidado en la vejez: estudios de caso en México
Authors: Enríquez Rosas Rocío , Ramírez García María Martha
Published: November 2023

En México “están emergiendo una serie de iniciativas y preocupaciones tanto desde el ámbito académico como desde organizaciones de la sociedad civil, que ubican al cuidado en el centro de su agenda” (Fraga, 2018, p.5). En Latinoamérica, en general, y en países como Uruguay (Rico, 2011), en particular, la familia es la principal proveedora de cuidados y, dentro de ella, las mujeres. Las desigualdades en la organización social del cuidado están íntimamente relacionadas con la crisis de cuidados actual. La débil respuesta de los Estados y sus instituciones en materia de cuidado, así como su mercantilización, han orillado a que las estrategias de resolución se asienten en las propias mujeres, en sus familias, en las relaciones entre vecinos y en el poder adquisitivo (Fraga, 2018). Es cada vez más imperiosa la necesidad de crear un sistema nacional de cuidados (Rico, 2011) que ponga el centro en el bienestar de todas las personas, en especial de las personas mayores, desde una perspectiva de derechos, y que contemple la universalidad del derecho al cuidado.
EXPERIENCE IN MANAGING A PATIENT WITH IDIOPATHIC PLEUROPARENCHYMAL FIBROELASTOSIS: FEATURES OF DIAGNOSIS AND TREATMENT
Authors:   Novosibirsk State Medical University, Kudelya L.M. ,   State Novosibirsk Regional Clinical Hospital, Novosibirsk, Russia, Khusainova E.S. ,   Novosibirsk State Medical University, Novosibirsk, Russia, Manakova Ya.L. ,   Novosibirsk State Medical University; State Novosibirsk Regional Clinical Hospital, Novosibirsk, Russia, Manzhileeva T.V. ,   Novosibirsk State Medical University; State Novosibirsk Regional Clinical Hospital, Novosibirsk, Russia, Mozhina L.N. ,   Novosibirsk State Medical University; State Novosibirsk Regional Clinical Hospital, Novosibirsk, Russia
Published: November 2023

Idiopathic pleuroparenchymal fibroelastosis (IPPFE) is a rare form of idiopathic interstitial pneumonia the etio¬logy of which is often unknown, and the course of the disease is usually rapidly progressive. The disease occurs with equal frequency in both men and women. Its onset usually is observed in the second half of life. Complaints are nonspecific: patients suffer from dry cough, shortness of breath, low body mass. A distinctive feature of IPPFE is the involvement of the apices of the lungs and development of platythorax, which can be easily detected in these patients during computed tomography. There is no specific treatment, but there is an evidence of positive experience with the use of antifibrotic drugs.
A CLINICAL CASE OF COMPREHENSIVE REHABILITATION IN PATIENT WITH A COMORBID NEURODEGERATIVE AND AUTOIMMUNE DISEASES
Authors:   PARUS medical resort & SPA, LLC, Novosibirsk region, Russia, Kholodkov N.I. , Dyachkov D.A. ,   PARUS medical resort & SPA, LLC, Novosibirsk region, Russia, Denisova О.А. ,   City Clinical Hospital No. 1, Novosibirsk, Russia, Drobyshev V.А. ,   Novosibirsk State Medical University, Novosibirsk, Russia, Gobruseva I.A. ,   PARUS medical resort & SPA, LLC, Novosibirsk region, Russia, Zueva K.Е. ,   PARUS medical resort & SPA, LLC, Novosibirsk region, Russia, Shmal А.V. ,   PARUS medical resort & SPA, LLC, Novosibirsk region, Russia, Utyakov А.R. ,   PARUS medical resort & SPA, LLC, Novosibirsk region, Russia, Root А.I. ,   PARUS medical resort & SPA, LLC, Novosibirsk region, Russia, Meliksetov G.V. ,   PARUS medical resort & SPA, LLC, Novosibirsk region, Russia, Kozyr K.V. ,   PARUS medical resort & SPA, LLC, Novosibirsk region, Russia, Pochueva I.E. ,   PARUS medical resort & SPA, LLC, Novosibirsk region, Russia, Levchenko N.V. ,   PARUS medical resort & SPA, LLC, Novosibirsk region, Russia
Published: November 2023

Motor neuron disease, in the vast majority of cases occurring in the form of amyotrophic lateral sclerosis is a rare neurodegenerative disease with a prevalence of 2–3 cases per 100 thousand people in the population. The paper presents the results of a clinical observation of a patient with probable amyotrophic lateral sclerosis which occurs comorbidly with autoimmune myositis since the diagnosis was made in January 2023, as well as the effect of a comprehensive 21-day rehabilitation on clinical characteristics in the rehabilitation department of PARUS medical resort & SPA, LLC, near Novosibirsk. The individual rehabilitation course included physical rehabilitation, restorative training, apparatus physiotherapy and occupational therapy in addition to medication. By the end of the rehabilitation course, the indicators of the measured clinical scales improved: ALSFRS-R – by 3 times, MRC muscle strength – 2 times, Barthel – 2 times, Beck – 1.5 times, according to the walking scale of the Institute of Neurology – 1.3 times, paresis scale of the Institute of Neurology – 2 times, dysphagia – 4.5 times. The study allows expanding and supplementing the available data regarding the difficulty of verifying the diagnosis which directly affects the complexity of assessing the rehabilitation prognosis, setting rehabilitation goals and objectives in a patient with difficult to differentiate comorbid pathology.
Diagnostic difficulties and features of the clinical picture of systemic lupus erythematosus in an adolescent (case report)
Authors:   Astrakhan State Medical University, Astrakhan, Russia, Sagitova G.R. , Antonova А.А. ,   Astrakhan State Medical University, Astrakhan, Russia, Rasshchepkina N.I. ,   Regional Children’s Clinical Hospital named after N.N. Silishcheva, Astrakhan, Russia
Published: November 2023

Systemic lupus erythematosus (SLE) occurs in different age groups, but the risk group is people aged 15 to 40, most often female adolescents and young women. In clinical practice, the issue of timely verification of the diagnosis of SLE remains relevant. This clinical case illustrates the onset of acute systemic lupus erythematosus in an adolescent, with rapid involvement of vital organs (kidneys, lungs) in the pathological process. At the initial stage, various diagnoses were discussed; however, a comprehensive examination of the patient was carried out only when the patient was admitted to a hospital. The diagnosis of SLE was confirmed on the basis of classifying criteria: clinical investigation data.
Health of adolescents in the Novosibirsk region during the pandemic of a novel coronavirus infection
Authors:   Novosibirsk State Medical University, Novosibirsk, Russia, Kondyurina E.G. , Anokhina Т.Yu. ,   Novosibirsk State Medical University, Novosibirsk, Russia, Shvedov E.G. ,   Center for Military Medical Expertise of the Conscription Center of the Novosibirsk region, Novosibirsk, Russia, Zelenskaya V.V. ,   Novosibirsk State Medical University, Novosibirsk, Russia, Likhanov А.V. ,   Novosibirsk State Medical University, Novosibirsk, Russia, Kovarenko M.А. ,   Novosibirsk State Medical University, Novosibirsk, Russia, Timinskaya N.G. ,   Novosibirsk State Medical University, Novosibirsk, Russia
Published: November 2023

Introduction. The pandemic of a novel coronavirus infection (COVID-19) has limited the work of planned medical preventive programs and, together with the consequences of the illness, the lockdown has had a negative impact on the psychosomatic status of the population. Aim. Analysis of the dynamics of the adolescent health in the Novosibirsk region during the COVID-19 pandemic which determine the immediate reserve of society. Materials and methods. The data on the incidence and disability of adolescents aged 15–17 years in the Novosibirsk region, health indicators of young men based on the results of medical examinations at the Regional Conscription Center during the COVID-19 pandemic (2020–2022) were analyzed. Process trends were recorded by graphical analysis of diagrams, trend modeling, calculation of growth rates and their ranking. Results. By the end of 2022, similar trends in the incidence and disability in the form of a significant positive growth rate were found for mental and behavioral disorders, diseases of the nervous system. In the health condition of young men of conscription age, the most negative dynamics was revealed for mental and behavioral disorders, diseases of the respiratory system, endocrine, nutritional and metabolic diseases. The latter were often overlooked during preventive examinations and were first diagnosed at the Conscription Center; their underdiagnosis was facilitated by the workload of the outpatient pediatric setting that worsened during the pandemic. Conclusion. The alarming trends in the health of adolescents in the Novosibirsk region during the pandemic indicate the need to introduce interdisciplinary algorithms for early diagnosis of the consequences of the disease and lockdown into the healthcare system, including both medical and sociopedagogical aspects.
Native Americans: Understanding Climate Change Impacts
Authors: Chumburidze Tea
Published: November 2023

Climate change is affecting the planet, societies and will continue to do so for generations to come. Differences in how regions are affected by varying degrees of warming, precipitation and changes in animal and plant species are likely to get even more extreme as climate change continues. Nowadays, Native Americans are experiencing the effects of dislocation and food shortages, which they attribute to the Climate Change. The article aims to elaborate the impact of the Climate Change on Native American communities, particularly, the research examines the basis for Native Nations to considerhow they may be affected by changes in climate and extreme measures they can take in order to proactively address those impacts.
Synonymic Row as a Device for Conveying Expressiveness of Prose Rhythm (Based on the Material of Georgian and English Rhythmic Prose)
Authors: GELDIASHVILI Nunu , GARIBASHVILI Manana
Published: November 2023

Among other lexical devices, synonyms possess a remarkably big potential as expressive means of rhythmic prose. With the help of synonyms one and the same notion may be expressed in two or more ways. In the article, we tried to show that in the research material in both Georgian and English there is almost complete coincidence in terms of meaning and function of synonyms as a rhythm forming device. The target readers of the article will be linguists and the researchers who study rhythm of prose.
A Motif Analysis on Avicenna’s Legends that have been Detected in Turkmenistan Area
Authors: SERBES Mustafa , GOKCEGOZOGLU Ahmet
Published: November 2023

The pride of Turkish-Muslim World Avicena has lived between 980-1037 years A.D. His full name is Ebu Ali el-Hüseyin bin Abdullah İbni Sina. He had extraordinary mental capacities in the following fields of science: Philosophy, Medicine, Physics, Chemistry, Mathematics, Geometry, Astronomy, Music, Geology, Literature. He had approximately written 150-200 works in the above mentioned fields of science. He was a scientist, a physician and a philosopher. In the West he is known by the following name: Avicena. His general epithets known from the literature are as follows: the Prince of Philosophers, the Sultan of Physicians, the Wonder Child of the East, The Grand Master, The Master Scientist. There exist various recorded legennds and saying regarding Avicena in Turkmenistan.In the given work we analyse the motives of four legends regarding İbni Sina (Avicena) recorded in Turkmenistan comparing them with the motives analysed in the work entitled Motif Index of Folk Literature by Stith Thompson. of the cultural oppression are.
Проблема гіперпластичних процесів в ендометрію у жінок репродуктивного віку
Authors: Bazyuta L. Z. , Рolyova S. P. , Tsintar S. А.
Published: November 2023

Наведено чинники ризику виникнення гіперплазії ендометрію (ГПЕ) у жінок репродуктивного віку. Показано, що ГПЕ розвивається у відповідь на порушення гормонального гомеостазу тканин-мішеней. Встановлено, що в регуляторних механізмах клітинного росту і диференціації ендометрію беруть участь біологічно активні речовини, тісно пов'язані з імунними механізмами функціонування репродуктивної системи.
Ефективність комбінації розувастатину і полікозанолу у хворих на стабільну ішемічну хворобу серця з помірно порушеною функцією печінки
Authors: Solomenchuk T. M. , Vosukh O. V. , Bedzay A. O. , Koval V. G. , Chepka I. M.
Published: November 2023

Наведено результати вивчення ліпідокоригуючої здатності та безпечності поєднаного застосування полікозанолу і розувастатину порівняно з монотерапією розувастатином у хворих на стабільну ішемічну хворобу серця (ІХС) з помірно порушеною функцією печінки. Дослідження включало 57 осіб віком від 37 до 72 років, середній вік – (54,4 ± 6,5) року, які не менше 8 тиж отримували статинотерапію, але у них не досягнуто цільового рівня холестерину ліпопротеїдів низької щільності (ХС ЛПНЩ) і було помірне підвищення активності печінкових ферментів. На початку дослідження і через 12 тиж спостереження у хворих визначали показники ліпідного спектра крові (загальний холестерин – ЗХС, ХС ЛПНЩ, холестерин ліпопротеїдів дуже низької щільності – ХС ЛПДНЩ, холестерин ліпопротеїдів високої щільності – ХС ЛПВЩ, тригліцериди – ТГ), перекисного окислення ліпідів (малоновий діальдегід – МДА), вміст глікозильованого гемоглобіну HbA1c (%) та контролювали функціональний стан печінки за рівнями гамма-глутамілтранспептидази (γ-ГТП) і аланінамінотрансферази (АлАТ). Встановлено, що застосування полікозанолу у поєднанні з розувастатином приводило до ефективнішого, ніж монотерапія розувастатином, зменшення проатерогенності ліпідного обміну шляхом зниження вмісту в плазмі крові ЗХС, ХС ЛПНЩ, ТГ, підвищення рівня ХС ЛПВЩ, зниження прооксидантної активності (МДА) при одночасному суттєвому покращанні функціонального стану печінки. Поєднаний прийом полікозанолу по 20 мг/доба і розувастатину по 10–20 мг/доба хворі переносили задовільно. У жодного з обстежених незареєстровано побічних ефектів, що потребувало б відміни цих препаратів.
THE RITE OF URBAN PASSAGE
Authors: Masoudi Reza
Published: November 2023

The Iranian city experienced a major transformation when the Pahlavi Dynasty initiated a project of modernization in the 1920s. The Rite of Urban Passage investigates this process by focusing on the spatial dynamics of Muharram processions, a ritual that commemorates the tragic massacre of Hussein and his companions in 680 CE. In doing so, this volume offers not only an alternative approach to understanding the process of urban transformation, but also a spatial genealogy of Muharram rituals that provides a platform for developing a fresh spatial approach to ritual studies.
WHEN WILL WE TALK ABOUT HITLER?
Authors: Oeser Alexandra
Published: November 2023

For more than half a century, discourses on the Nazi past have powerfully shaped German social and cultural policy. Specifically, an institutional determination not to forget has expressed a “duty of remembrance” through commemorative activities and educational curricula. But as the horrors of the Third Reich retreat ever further from living memory, what do new generations of Germans actually think about this past? Combining observation, interviews, and archival research, this book provides a rich survey of the perspectives and experiences of German adolescents from diverse backgrounds, revealing the extent to which social, economic, and cultural factors have conditioned how they view representations of Germany’s complex history.
MEN UNDER FIRE
Authors: Hutečka Jiří
Published: November 2023

In historical writing on World War I, Czech-speaking soldiers serving in the Austro-Hungarian military are typically studied as Czechs, rarely as soldiers, and never as men. As a result, the question of these soldiers’ imperial loyalties has dominated the historical literature to the exclusion of any debate on their identities and experiences. Men under Fire provides a groundbreaking analysis of this oft-overlooked cohort, drawing on a wealth of soldiers’ private writings to explore experiences of exhaustion, sex, loyalty, authority, and combat itself. It combines methods from history, gender studies, and military science to reveal the extent to which the Great War challenged these men’s senses of masculinity, and to which the resulting dynamics influenced their attitudes and loyalties.
BIG CAPITAL IN AN UNEQUAL WORLD
Authors: Armytage Rosita
Published: November 2023

Inside the hidden lives of the global “1%”, this book examines the networks, social practices, marriages, and machinations of Pakistan’s elite. Benefitting from rare access and keen analytical insight, Rosita Armytage’s rich study reveals the daily, even mundane, ways in which elites contribute to and shape the inequality that characterizes the modern world. Operating in a rapidly developing economic environment, the experience of Pakistan’s wealthiest and most powerful members contradicts widely held assumptions that economic growth is leading to increasingly impersonalized and globally standardized economic and political structures.
THE BEST WE SHARE
Authors: Brumann Christoph
Published: November 2023

The UNESCO World Heritage Convention is one of the most widely ratified international treaties, and a place on the World Heritage List is a widely coveted mark of distinction. Building on ethnographic fieldwork at Committee sessions, interviews and documentary study, the book links the change in operations of the World Heritage Committee with structural nation-centeredness, vulnerable procedures for evaluation, monitoring and decision-making, and loose heritage conceptions that have been inconsistently applied. As the most ambitious study of the World Heritage arena so far, this volume dissects the inner workings of a prominent global body, demonstrating the power of ethnography in the highly formalised and diplomatic context of a multilateral organisation.
DELTA LIFE
Authors: Krause Franz , Harris Mark
Published: November 2023

Proposing a series of innovative steps towards better understanding human lives at the interstices of water and land, this volume includes eight ethnographies from deltas around the world. The book presents ‘delta life’ with intimate descriptions of the predicaments, imaginations and activities of delta inhabitants. Conceptually, the collection develops ‘delta life’ as a metaphor for approaching continual and intersecting sociocultural, economic and material transformations more widely. The book revolves around questions of hydrosociality, volatility, rhythms and scale. It thereby yields insights into people’s lives that conventional, hydrological approaches to deltas cannot provide.
EVALUATION OF ASPHALT PAVEMENT PERFORMANCE FOR DIFFERENT DIATOMITE CONTENT
Authors: AKSOY Atakan , ASLAN Mustafa Taha , İSKENDER Erol , AYYILDIZ Dündar , ŞENGÜL Celaleddin Ensar
Published: November 2023

The majority of steel and reinforced concrete bridges are produced with asphalt pavement. The reason for this is to protect steel and concrete structures from the effects of water and degrading salt additives and to increase their durability. Asphalt bridge superstructures are mostly manufactured with four layers. These layers are the primer bonding layer, waterproofing layer, protection layer and surface asphalt wearing layers. The superstructure must protect the supporting substructure. It should protect the life of the structure and ensure the integrity of the structure against permanent deformation, aging, raveling, water damage and chemical effects. Diatomite additive is used as a performance enhancer in various aspects. It is generally preferred in the region of 5%-15% according to the bitumen mass. The granulometric size and chemical properties of the diatomite additive are other effective factors. In this study, the rutting resistance of conventional and diatomite-modified asphalt pavement for 5% and 10% ratios for selected diatomite additive gradation is investigated. The rutting resistance of the pavements is investigated by repeated creep tests for two different additive ratios on water-damaged and control mixtures. In unconditioned samples, 5% diatomite-modified mixtures; in conditioned samples, 10% diatomite-modified mixtures showed the greatest deformation resistance.
POLİLAKTİK ASİT/ POLİ (STİREN-KO-METİL METAKRİLAT) /HALLOYSİT NANOKOMPOZİTLERİNİN ÖZELLİKLERİ ÜZERİNE HALLOYSİT VE POLİLAKTİK ASİT MİKTARININ ETKİSİ
Authors: İSKENDER Dilan , ALTINTEN Ayla
Published: November 2023

Bu çalışmada stiren ve metilmetakrilat monomerlerinden emülsiyon polimerizasyonu yöntemi ile Poli(stiren-ko-metilmetakrilat) (P(St-ko-MMA)) sentezlenmiştir. (P(St-ko-MMA))’ya kullanım ömrü süresince mekanik ve termal özelliklerinin geliştirilmesi amacıyla dimetil sülfoksit (DMSO) ile modifiye edilmiş nano takviye malzemesi olan modifiye halloysit nanotüp (m-HNT) ve biyobozunur özellik kazandırmak amacıyla Polilaktik asit (PLA) katılmıştır. In-situ ve çözelti harmanlama yöntemleri ile kütlece 30:70 ve 50:50 oranlarında PLA/P(St-ko-MMA) içeren kütlece %5 ve %10 oranlarında m-HNT kullanılarak PLA/P(St-ko-MMA)/HNT nanokompozit sentezi gerçekleştirilmiştir. Kopolimer ve nanokompozitlerin % monomer dönüşümleri ve viskozite ortalama molekül ağırlıkları hesaplanmış ardından karakterizasyon çalışmaları gerçekleştirilmiştir. Kopolimer ve nanokompozitlerin termal özellikleri Termogravimetrik Analiz (TGA), yapısal özellikleri Taramalı Elektron Mikroskobu (SEM) ve mekanik özellikleri Shore D ile gözlemlenmiştir. PLA’nın nanokompozit üzerindeki etkisini gözlemleyebilmek için plaka haline getirilen numuneler kaktüs toprağı ve humuslu toprağa gömülmüştür. Çalışmanın sonunda HNT ve PLA miktarındaki değişimlerin ve nanokompozit sentezleme yöntemlerinin nanokompozitlerin özellikleri üzerindeki etkileri incelenmiştir. Karakterizasyon çalışmalarında nanokompozitlerin artan HNT katkısı ile özelliklerinin arttığı görülmüştür. Çözelti harmanlama yöntemi ile üretilen nanokompozitlerin mekanik dayanım konusunda daha iyi özellikler sergilediği fakat termal dayanım konusunda kullanılan nanokompozit sentezi yöntemlerinin birbirine üstünlüğü olmadığı görülmüştür. PLA miktarının artışı mekanik ve termal dayanımı negatif yönde etkilediği görülmüş fakat biyobozunma konusunda pozitif etkisi olduğu saptanmıştır.
Bibliometric analysis of carsharing and car rental research in the field of urban transportation and tourism transportation
Authors: Akay Bayram
Published: November 2023

This paper reviews recent carsharing and car rental research bibliometrically. The study examines the evolution, structure, and boundaries of Web of Science-reviewed carsharing and car rental research. VOSviewer and SPSS 22 evaluated 204 vehicle rental and 574 carsharing articles in the WOS core collection. A gradual rise in car rental and carsharing studies is shown. China and the US produce the most carsharing and rental publications, respectively. China is the most productive country for carsharing publications and the United States for car rental publications. While China and the United States cooperate on carsharing, the United States cooperates with other countries (Canada, Germany, England, France, Australia, Portugal, Taiwan, Israel) on car rental. Co-occurrence network analysis shows that carsharing has five main themes: sharing economy, electric vehicles, transportation, shared mobility, and mobility as a service, while car rental research has four main themes: revenue management, transportation, quality service, and e-commerce. Carsharing and car rental studies share transportation themes. Carsharing subjects include transportation, engineering, business economics, environmental science ecology, science technology, and computer science, while car rental subjects include management, operations research, economics, transportation, business, transportation science technology, business finance, engineering, tourism, and environmental science. Car rental concerns vary by management, tourism, and finance. Tourism literature neglects car hire. This study thoroughly reviews 26 years of automobile rental and 22 years of carsharing literature. Thus, it can help academics comprehend automobile rental and carsharing studies and direct future research.
PERAMALAN GENRE FILM TERPOPULER BERDASARKAN DATASET MYMOVIE MENGGUNAKAN METODE AUTOREGRESSIVE INTEGRATED MOVING AVERAGE (ARIMA)
Authors: Asrul  , Witanti Wina , Umbara Fajri Rakhmat
Published: November 2023

At this time the film industry is experiencing very rapid progress, this is because extraordinary technological developments have had a major influence on the film industry. Successful films tend to have a large audience. To find out why the audience likes a film, there are several variables that must be considered, one of which is the genre of the film. This research was conducted to predict what film genres the audience is most interested in. To predict the genre of this film using the autoregressive integrated moving average (arima) method. The autoregressive integrated moving average (arima) method or commonly known as the Box-Jenkins method is a method used to make precise and accurate short-term forecasts, compared to long-term forecasts which usually tend to be flat (flat/constant). From this research a prediction of the popularity or number of viewers of each film genre will be generated which can be used as a reference to find out what genre of film the audience is interested in. So that film production companies can adjust film releases according to their interests. audience, in order to gain greater profits.
KESIAPAN GENERASI X DALAM MENGHADAPI LINGKUNGAN KERJA BERWAWASAN DIGITAL PADA RSUD SITI FATIMAH AZ-ZAHRA
Authors: Monica Vira , Mellita Dina
Published: November 2023

Lingkungan kerja merupakan salah satu factor yang mempengaruhi salah satu kinerja karyawan. Kenyataan perubahan demogafis Angkatan kerja mulai di dominasi oleh lingkungan kerja sekarang yaitu lingkungan kerja digital. Adanya perubahan lingkungan kerja sekarang tersebut menuntun perubahan cara karyawan melakukan pekerjaan. Seperti yang diketahui lingkungan kerja saat ini sudah berkembang dengan menggunakan teknologi. Model kerja beralih dari lingkungan berbasis kantor dengan memanfaatkan teknologi online atau virtual. Fenomena yang terjadi di lapangan bahwa tidak sedikit karyawan yang resah terhadap perubahan lingkungan kerja terutama pada teknologi yang semakian berkembang. Adanya pemahaman dan pengetahuan yang minim dan membuat karyawan di tuntut harus mengikuti perkembangan teknologi. Hal tersebut lah yang membuat karyawan mempertimbangkan komitmen dan keberlanjutan kerja pada perusahaan. Penelitian ini dilakukan di Rumah Sakit Umum Daerah (RSUD) Siti Fatimah Az-Zahra yang beralamatkan di Jl. Kol. H. Burlian Suka Bangun Kecamatan Sukarami Palembang. Populasi dalam penelitian ini berjumlah 272 Pegawai, kemudian pengambilan sampel menggunakan teknik slovin dengan jumlah 73 pegawai generasi X. Teknik pengumpulan data dalam penelitian ini, peneliti melakukan observasi, wawancara dengan beberapa pegawai serta melakukan dokumentasi dan pengumpulan kuesioner. Teknik analisis yang digunakan ialah analisis regresi logistik. Hasil dari penelitian ini menunjukan bahwa lingkungan kerja berwawasan digital berpengaruh terhadap kesiapan kerja generasi X RSUD Siti Fatimah Az- Zahra.
PENGARUH ADULT PLAYFULNESS TERHADAP PERILAKU INOVATIF DI JABODETABEK
Authors: Sekarkinasih Annisa Ayudya , Revalina R. , Wijanarko Adrian
Published: November 2023

Sumber daya manusia merupakan unsur yang akan terlibat dalam kegiatan perusahaan. Perusahaan pastinya memiliki goals yang akan dicapai yang didukung oleh sumber daya manusia atau yang disebut karyawan. Di dalam perusahaan karyawan dapat memberikan kontribusi berupa ide dan kreativitas yang dapat meciptakan nilai baru bagi perusahaan. Kreativitas yang dimiliki karyawan yang akan menghasilkan inovasi. Dari kreativitas dan inovasi tersebut yang dapat diimplementasikan dan dikembangkan oleh perusahaan. Penelitian ini dihasilkan dengan menyebar google form yang berisi kuesioner berjumlah 28 pertanyaan dengan 22 pertanyaan pada variabel adult playfulness dan 6 pertanyaan pada variabel perilaku inovatif. Ukuran sampel efektif terdiri dari 102 responden yang kuesionernya telah diisi dan digunakan untuk analisis. Teknik analisis data yang digunakan dalam penelitian ini adalah analisis deskriptif, uji validitas, uji reliabilitas, uji hipotesis meliputi: regresi linier sederhana, uji T dengan SPSS. Berdasarkan uji parsial (uji T) yang sudah dilakukan, pada pengujian ini dapat disimpulkan bahwa variabel X memiliki T hitung 7,881 > T tabel 1,984, maka hipotesis adanya pengaruh adult playfulness terhadap perilaku inovatif diterima. Dan variabel X memiliki nilai signifikansi sebesar 0,000 > 0,050 yang berarti variabel adult playfulness (X) memberikan pengaruh positif dan signifikan terhadap variabel perilaku inovatif (Y).
Anatomical cup implantation assisted with dynamic 3D planning improves functional outcomes in primary total hip arthroplasty: A retrospective study
Authors: Sun Zhenhui , Li Nan , Yang Zhi , Zhang Wenhui , Liu Jie
Published: November 2023

BACKGROUND: Anatomical cup implantation is a promising approach in primary total hip arthroplasty (THA) and improves functional outcomes. OBJECTIVE: We aimed to evaluate the cup position and functional outcomes in primary THA with preoperative dynamic 3D planning. METHODS: We retrospectively reviewed 54 hips in 48 patients who underwent primary THA with anatomical cup implantation (mean follow-up time: 52 months). Cup positions were evaluated based on patient-specific morphology, the acetabular fossa and the combined anteversion test. Functional outcomes were assessed after THA. The paired-sample t-test was performed for surgical and contralateral native hips among 42 patients who underwent unilateral THA. RESULTS: Two hips suffered intraoperative trochanteric fracture, but no hip dislocations occurred. No patients reported groin or thigh pain, and all patients were capable of deep squatting and one-leg standing. The mean Harris hip score, WOMAC score, and physical SF-36 score were 94.46 ± 6.16, 10.41 ± 3.62, and 95.19 ± 8.74, respectively. Except for acetabular offset, THA restored biomechanics to those of contralateral native hip, including cup anteversion, abduction, femoral offset and acetabular height (P> 0.05). CONCLUSION: This study provided evidence for the application of anatomical cup implantation assisted with dynamic 3D planning in primary THA, which restored morphology and improved functional outcomes.
Urinary VOCs as biomarkers of early stage lung tumour development in mice
Authors: Gouzerh Flora , Vigo Gwenaëlle , Dormont Laurent , Buatois Bruno , Hervé Maxime R. , Mancini Maicol , Maraver Antonio , Thomas Frédéric , Ganem Guila
Published: November 2023

BACKGROUND:

Lung cancer is the primary cause of cancer-induced death. In addition to prevention and improved treatment, it has increasingly been established that early detection is critical to successful remission.

OBJECTIVE:

The aim of this study was to identify volatile organic compounds (VOCs) in urine that could help diagnose mouse lung cancer at an early stage of its development.

METHODS:

We analysed the VOC composition of urine in a genetically engineered lung adenocarcinoma mouse model with oncogenic EGFR doxycycline-inducible lung-specific expression. We compared the urinary VOCs of 10 cancerous mice and 10 healthy mice (controls) before and after doxycycline induction, every two weeks for 12 weeks, until full-blown carcinomas appeared. We used SPME fibres and gas chromatography – mass spectrometry to detect variations in cancer-related urinary VOCs over time.

RESULTS:

This study allowed us to identify eight diagnostic biomarkers that help discriminate early stages of cancer tumour development (i.e., before MRI imaging techniques could identify it).

CONCLUSION:

The analysis of mice urinary VOCs have shown that cancer can induce changes in odour profiles at an early stage of cancer development, opening a promising avenue for early diagnosis of lung cancer in other models.
Comprehensive analysis of thirteen-gene panel with prognosis value in Multiple Myeloma
Authors: Zheng Tingting , Chen Panpan , Xu Yuanlin , Jia Peijun , Li Yan , Li Yating , Cao Jiaming , Li Wanxin , Zhen Yazhe , Zhang Ying , Zhang Shijie , Du Jiangfeng , Zhang Jingxin
Published: November 2023

BACKGROUND: Although there are many treatments for Multiple myeloma (MM), patients with MM still unable to escape the recurrence and aggravation of the disease. OBJECTIVE: We constructed a risk model based on genes closely associated with MM prognosis to predict its prognostic value. METHODS: Gene function enrichment and signal pathway enrichment analysis, Least Absolute Shrinkage and Selection Operator (LASSO) regression analysis, univariate and multivariate Cox regression analysis, Kaplan-Meier (KM) survival analysis and Receiver Operating Characteristic (ROC) analysis were used to identify the prognostic gene signature for MM. Finally, the prognostic gene signature was validated using the Gene Expression Omnibus (GEO) database. RESULTS: Thirteen prognostic genes were screened by univariate Cox analysis and LASSO regression analysis. Multivariate Cox analysis revealed risk score to be an independent prognostic factor for patients with MM [Hazard Ratio (HR) = 2.564, 95% Confidence Interval (CI) = 2.223–2.958, P< 0.001]. The risk score had a high level of predictive value according to ROC analysis, with an area under the curve (AUC) of 0.744. CONCLUSIONS: The potential prognostic signature of thirteen genes were assessed and a risk model was constructed that significantly correlated with prognosis in MM patients.