bluuebunny/crossref_metadata_2025 huggingface dataset:
Unusual location of the ectopic salivary glands – a case report
Authors: Rutowicz Maria , Wolniewicz Maria , Piórkowska Paula , Zawadzka-Głos Lidia
Published: February 2024

Under the term „salivary heterotopia” we can distinguish 3 entities, which are accessory salivary glands, branchial cleft anomalies containing salivary gland tissue and finally heterotopic salivary gland tissue (HSGT). True HSGT is defined as presence of a normal salivary tissue outside of the major, minor, or accessory salivary glands, together with exclusion of clinical and histopathological features characteristic for branchial cleft anomalies. It is a rare condition, usually localized in the lower neck region. It is important to remember that it reacts with physiological saline-production stimulation and can be affected by all salivary glands’ disorders. In our article we would like to present a case of a 7-year-old boy presented with pedunculated, red, globular lesion in the right posterior tonsillar arch, which was diagnosed as an ectopic salivary gland.
Diagnostic difficulties in determining the cause of congenital respiratory stridor in an infant with multiple congenital abnormalities – a case report
Authors: Jabłońska-Jesionowska Monika , Zawadzka-Głos Lidia
Published: February 2024

The term respiratory stridor refers to cases in which an additional pathological, loud sound is heard during breathing, and it always indicates narrowing of the lumen of the airways. The pathological change causing airway obstruction can be of various nature and can occur at any level of the airway. It can also be a lesion outside the lumen of the airway and cause a respiratory problem through external pressure. Diagnostics of stridor is based on complementary endoscopic and imaging tests. There is no one perfect method that allows to make a diagnosis. In our study, we wanted to present diagnostic difficulties in determining the cause of respiratory stridor in a several days old female infant with numerous congenital defects in the facial skeleton, neck and heart.
An unusual presentation of an intraorbital abscess associated with an extensive dental caries and pulp gangrene in a 14-years old boy with asthma and obesity
Authors: Demianiuk Sonia , Pilch Maciej , Zawadzka-Głos Lidia
Published: February 2024

We present an unusual case of a 14-year-old patient who was admitted as an emergency to the hospital with oedema of right orbit with restricted eye movements. Severe asthma from the seventh month of age and obesity were reported. Radiologic examination showed the existence of an intraorbital abscess. He also presented an extensive dental caries and pulp gangrene in seventeen teeth and unilateral sinusitis confirmed in the Computed Tomography scan. Emergency treatment including an oral surgeon’s intervention, which is extraction of seventeen teeth, drainage of the abscess, antibiotics and glucocorticoids was introduced resulting in an immediate improvement of patient’s health status, leading to recovery. The objective of this clinical presentation is to highlight associations between dental status and cellulitis. Infection from decayed teeth in children can lead to unilateral sinusitis, resulting in severe complications such as an intraorbital abscess. It is strongly recommended to put more effort into oral hygiene and healthy lifestyle to avoid serious complications – especially in asthmatic patients.
Intracranial complication of acute paranasal sinusitis during active COVID-19 infection – a case report
Authors: Piotrowska Alicja , Frąckiewicz Magdalena , Zawadzka-Głos Lidia
Published: February 2024

According to various sources, complications of sinusitis occur with a frequency of between 3 and 17%. Intracranial complications include: meningitis, epidural abscess, subdural abscess, brain abscess, and thrombophlebitis of the dura mater and the brain. The most common intracranial complications are inflammations of the frontal, ethmoid and sphenoid sinuses. A brain abscess is the second most common intracranial complication in the course of sinusitis after meningitis. The presented case concerns a 16-year-old patient treated for brain abscesses and CNS sinus thrombosis in the course of acute purulent inflammation of the frontal and maxillary sinus on the right side. The management of intracranial complications of acute paranasal sinusitis according to EPOS 2022 is high doses of intravenous antibiotics used for a long period, neurosurgical surgical treatment consisting in drainage of abscesses through craniotomy, drainage of the frontal sinus from external or endoscopic access. The prognosis of intracranial complications most often depends on the severity of neurological symptoms and appropriate prompt treatment implementation.
Retropharyngeal abscess as an example of a deep neck infection in children
Authors: Jędrychowski Jakub , Wolniewicz Maria , Zawadzka-Głos Lidia
Published: February 2024

Deep neck infections are severe complications of the inflammatory processes in the upper respiratory tract. They can be divided into retropharyngeal, parapharyngeal, peritonsillar and submandibular abscesses, depending on the affected region. Deep neck infections are considered as acute bacterial complications with a progressive course and life-threatening character and that’s why they require immediate wide-range, intravenous antibiotic therapy. A 7-year-old female patient presented to her general practitioner with persistent, recurrent fever lasting for 3 days. Fever subsided after 2 days of antibiotic therapy, but she developed trismus, severe sore throat, especially on the right side, radiating to the right ear and dysphagia. The patient was referred to the Pediatric Otolaryngology Department as a matter of urgency. On examination she had enlarged lymph nodes on the right side of the neck with limited head and neck movements to the right side and posteriorly. There was also an asymmetry of the pharynx behind the right palatopharyngeal arch observed. Laboratory blood tests showed high CRP level (3.84 mg/dl, n < 0.5). CT scan was performed and showed multiloculated abscess in right retropharyngeal space. Our patient was qualified for the surgical procedure – drainage of the abscess under general anaesthesia together with wide spectrum antibiotic therapy in a form of cefuroxime and clindamycin. During procedure a large amount of pus was evacuated, and a sample was sent for microbiological results. It showed growth of Staphylococcus hominis, probably multiplication of local physiological colonization. She also received anti-inflammatory drugs and has had physiotherapy throughout the hospitalization period to prevent torticollis. We observed gradual local and general improvement, together with normalization of the inflammatory markers. She was discharged from the hospital after 7 days of intravenous treatment. Accurate diagnosis and immediate proper treatment of deep neck infections are essential in prevention of further local (to the surrounding regions) and general expansion (like thrombosis, sepsis, meningitis) of the inflammatory process and of persistent changes (like stenosis of the respiratory tract). Fortunately, in the post-antibiotic era most patients are fully healed, further complications are almost unseen and mortality rates are low.
Treatment methods of obstructive sleep apnea (OSA) in children with adenoid hypertrophy and contraindications for adenectomy
Authors: Wolniewicz Maria , Zawadzka-Głos Lidia
Published: February 2024

Obstructive sleep apnea (OSA) is a common problem in pediatric population, most frequently caused by the adenoid hypertrophy. Improper sleep pattern leads to an inadequate night rest and therefore influences daytime behavior. The easiest method of treatment in such cases is adenectomy, which means the excision of the adenoid (so called „third tonsil”). Obviously, it should be performed only after an objective confirmation of the etiology in the fiberoscopy. Children with defects in the palatine, like „overt” and „occult” submucous cleft palate, cleft palate or after palatine reconstructions, stand for an exceptional group of patients. On one hand, all the reconstructive surgeries increase the risk of an obstructive sleep apnea in such children, while on the other hand palatal defects are a classic contraindication for adenectomy. Adenectomy is contraindicated due to an increased risk of velopharyngeal insufficiency, which impairs the act of swallowing and speech. When aggravated symptoms are observed, after specialist phoniatrics consultation, a partial adenectomy should be considered. This procedure means partial excision of the adenoid, where only the superior part of the adenoid, responsible for the blockage of the airflow through posterior choanae, is excised, and at the same time the inferior part is left, providing contact between the adenoid and the soft palate (what is responsible for the preservation of veloadenoidal closure).
Residual nasal foreign body – a case report and review of literature
Authors: Piórkowska Paula , Wolniewicz Maria , Zawadzka-Głos Lidia
Published: February 2024

Nasal foreign bodies (NFB) account for up to 4.3% of all emergency otorhinolaryngological consultations in pediatric population. They mainly concern children aged 2-5 years old. If they remain unnoticed by a parent (e.g event happening without parental control, NFB hidden and forgotten by a child), they may stay asymptomatic for an unknown period (depending on the type of NFB and various additional circumstances) until further complications develop. Prolonged undiagnosed NFB may result in cartilage necrosis, what may lead to septal perforation or in extreme cases even to sepsis and meningitis. That is why, it is important to increase parents’ and caregivers’ awareness concerning this problem to prevent such hazardous complications. In our article we would like to present a case of a 2.5-year-old girl referred to our department by a pediatrician due to unilateral rhinitis with suspected residual nasal foreign body since unknown period, followed by mucous healing complications. We also conducted a literature review concerning the issue of NFB, and then analyzed.
Congenital pediatric nasal dermoid on the lateral part of the nasal root ? a series of two cases
Authors: Marcinkiewicz Bartosz , Zawadzka-Głos Lidia
Published: February 2024

Nasal dermoid cysts are rare congenital defect resulting from an abnormality in embryonic development. They are usually located along the fusion line of the germ layers. When present superficially, nasal dermoid cysts are easy to detect and appear as firm, non-pulsating, slow-growing masses. The treatment of choice is complete surgical removal, regardless of their size. In any case, computed tomography (CT) should be performed before surgical treatment to exclude a possible intracranial connection. We present two cases of patients admitted to the hospital for the removal of nasal dermoid cyst. The performed CT examinations excluded the presence of communication with the cranial cavity. No postsurgical complications were observed. Postoperative histopathological examinations confirmed the diagnosis of dermatoid cysts.
Recent trends in the treatment of benign proctological diseases in relation to historical methods. What has changed? What has survived?
Authors: Kołodziejczak Małgorzata , Ciesielski Przemysław
Published: February 2024

This paper presents the latest trends in the treatment of benign proctological diseases such as haemorrhoidal disease, anal fissure, anal fistula, hair cyst and incontinence, based on the literature and our own experience, as well as referring to historical methods. The last few decades have seen a leap in the development of diagnostic imaging methods. Furthermore, improvements in surgical equipment have contributed to new surgical techniques. This article discusses minimally invasive techniques, with particular emphasis on endoscopic methods, in the treatment of haemorrhoidal disease and indications for their use, as well as trends in the treatment of anal fistulas, anal fissures and incontinence. Comparison of modern and historical therapeutic approaches used in proctological diseases showed that despite advances in diagnosis, surgical methods and equipment, as well as pharmacotherapy used, most principles for treating proctological patients have persisted. The basic principles of aiming to preserve continence and limit infection remained unchanged.
The impact of electrostimulation and EMG-biofeedback therapy on the distribution and coordination of anal sphincter muscle tone based on the example of two randomly selected patients with fecal incontinence
Authors: Namysł Jan
Published: February 2024

Damage to the pelvic floor muscles, which are responsible for sphincter functions, and diseases or injuries of the nerves that control their bioelectric activity are always associated with functional changes manifested in the form of discoordination of motor units, in muscles involved in contraction. As a result of difficult or impossible communication between neural centres that regulate sphincter tone and proprioceptors, muscle tone becomes unstable, modulated inadequately to the needs and generating many undesirable symptoms, as bioelectric voltage has a significant impact on the vital functions of muscle and nerve cells. An assessment of muscular activity expressed in objective units, i.e. microvolts, is possible only with electromyography. Self-performed exercises and electrostimulation may fail to produce the desired improvement in the case of degraded nervous mechanisms underlying the distribution and coordination of muscle activity. Electrostimulation and EMG-biofeedback therapy help normalise bioelectrical activity and thus contribute to the healing process. Plasticity of the nervous system allows for the creation of new neural networks that normalise muscle tone and improve control over sphincter activity as a result of patient’s conscious involvement in EMG-biofeedback therapy.
Anterior and posterior horseshoe abscess – drainage with multiple radial incisions. A case report
Authors: Krasińska Katarzyna , Venhura Alesia , Papierski Maciej , Głowacki Szymon
Published: February 2024

We present a case of a 30-year-old male treated for massive anterior and posterior horseshoe abscess posing a threat of Fournier’s gangrene. The patient presented at the hospital with fever and anal pain. He reported in his medical history that he had been treated for sciatica for 7 days. Rectal examination revealed anal and perineal phlegmon. The patient was qualified for urgent surgical intervention. Under general anesthesia, multiple radial incisions were made around the anus, exposing the deep postanal space. A massive anterior and posterior horseshoe abscess was diagnosed intraoperatively. No fistula was found intraoperatively. Broad-spectrum antibiotic therapy was initiated. Setons were used for the wounds, with anesthesiologist-assisted seton replacement under short-term sedation. Septic shock was successfully managed. In the days that followed, the wounds haled properly. The patient was discharged for further outpatient follow-up. After 2 months, the patient reported a slight incision leakage at 1 o’clock in the lithotomy position. He was referred for transrectal ultrasound due to suspected fistula. Conclusions: 1. A horseshoe abscess is an extensive anorectal infection requiring rapid surgical intervention. 2. Radial incisions of horseshoe abscesses are an effective method of abscesses drainage. 3. Postoperative seton replacement is a safe and proper wound healing method, but often requires analgosedation.
The place of the Suchorski method in the contemporary treatment of extensive pilonidal sinus disease – a literature review
Authors: Marcinkowska Daria , Glinkowski Sławomir
Published: February 2024

Pilonidal sinus disease (PSD) is a chronic inflammation of the sacrococcygeal area. It is more prevalent among men, mainly those in their 20s and 30s. Many patients develop an abscess in this region as the first sign of the disease. In such cases, abscess incision and drainage are necessary. Surgery is the only effective treatment for pilonidal cyst. Many surgical techniques have been developed, with each of them having specific indications. Regardless of the surgical strategy, the essence of each method should be to lift and flatten the gluteal cleft to prevent recurrence. The Suchorski method, which is also referred to as oblique excision in the literature, is a method with proven high efficiency and low recurrence rates. Cases where the external opening remains in close proximity to the anal canal are a particular indication for this technique. In such cases, it allows for the total excision of the cyst, while maintaining sphincter continuity. In this paper, we review papers on the efficacy of the Suchorski method compared to other techniques. Despite excellent treatment outcomes, the Suchorski technique still seems to be an underestimated method.
Opieka stomatologiczna nad pacjentem z grupy ryzyka martwicy kości szczęk w gabinecie stomatologicznym
Authors: Słowik Łukasz , Nowak Aleksy , Okła Maciej , Ślebioda Zuzanna , Osmola Krzysztof , Totoń Ewa
Published: February 2024

In dental patients, osteomyelitis is a heterogeneous group of diseases that result in non-healing, progressive destruction of the jaw and mandible as a result of the ongoing inflammatory process. As a result of the untreated inflammatory process, bone tissue necrosis occurs. Among the inflammatory lesions of the jaws, the largest group are radiation- and drug-induced lesions as a result of long-term oncological treatment. In the pediatric population, osteitis after radiotherapy mainly affects long bones. There have been no reports of drug induced osteonecrosis in younger patients. Knowledge, including the factors increasing the risk of osteomyelitis in the maxillary area and prophylaxis, carried out correctly by dentists, contribute to the elimination of this difficult-to-treat complication. This study aims to present the characteristics of the disease, its etiology, and risk factors. This study shows the perioperative procedure according to the guidelines of the Working Group of the Polish Dental Society and the National Program for the Protection of Antibiotics.
Ewolucja płukanek – przegląd piśmiennictwa
Authors: Aluchna Alicja
Published: February 2024

Introduction. Mouthwashes were developed to aid oral hygiene and decontamination. They can be single-ingredient or multi-ingredient (active ingredients [antibacterial and/or antifungal], emulsifiers, detergents, acids, colourings, fragrances and flavourings, water, some alcohol). The first mouthrinse, with a documented formulation, is Listerine® and is already 150 years old. Aim. Presentation the current state of knowledge on mouthwashes with regard to their effects on the human body (human cell vitality) and restorative materials (change in color, roughness, hardness). Material and methods. Pubmed, Scopus, Wiley databases were searched, including keywords: “mouthwash”, “mouthrinse”, “composite”, “hardness”, “roughness”, “colour stability”. Results. The effects of the individual active substances (fluoride compounds, xylitol, chlorhexidine, cetylpyridinium chloride, essential oils, herbal extracts) are presented and discussed. Mouthwashes were ranked according to own classification. Indications, contraindications and the most important factors modifying the conditions of use of the mouthrinses with regard to their active ingredients were discussed. The effects of the mouthrinses on living cells and dental restorative materials were discussed. Conclusions. Mouthwashes are an important component in the fight against biofilm (chemical component), and are an integral component of proper oral hygiene. Technological advances and the deepening of the state of knowledge necessitate an update of the rules of their use. The issue of potential interactions not only of the active ingredients, but of all rinse components with both human body cells and dental restorative materials remains important.
Most kompozytowy modelowany bezpośrednio – obserwacja 15-letnia
Authors: Aluchna Alicja , Aluchna Marcin
Published: February 2024

The practical combination of the potential of bonding systems, composite materials and synthetic fibres opens up new possibilities for the restoration of qualitative and quantitative deficiencies. The use of a fibre filler significantly changes the mechanical properties of the composite material. This study presents the restoration of missing tooth 24 with a fibre-reinforced composite bridge. As a bridge pillars were used: tooth 23 – after endodontic treatment and tooth 25 – with preserved vitality and fixed filling covering the proximal wall and chewing surface. The work was carried out by direct modelling in the oral cavity. The restoration was made from two different types of composite material: a light-curing and a light-chemically-curing dual-activation polymerisation system. The materials use a different filler and matrix. The structure was reinforced with 16,000 glass fibres arranged in parallel. Systematic check-ups and periodic prophylactic treatments avoided complications and preserved function over a 15-year follow-up time. The methods and materials used allowed to achive permanent adhesion and functional-aesthetic restoration of the quantitative deficit of 24 and qualitative deficiencies of teeth 23 and 25. Fifteen years of observations confirmed the effectiveness and durability of the used solution.
Postępowanie kliniczne w amelogenesis imperfecta w wieku rozwojowym – przypadki kliniczne
Authors: Kapuścińska Barbara , Węgrzyn Renata , Barszcz Aleksandra , Perz Natalia , Miłoszewska-Paluch Anna , Turska-Szybka Anna , Olczak-Kowalczyk Dorota
Published: February 2024

Amelogenesis imperfecta is a hereditary defect of enamel. It can affect both the primary and permanent dentition. It manifests as: change in enamel structure, shape of teeth, severe malocclusion and can also co-occur with changes in other tissues derived from the ectoderm. In the literature there are several classifications of this disease, the two main ones are the four-stage classification according to Witkop (1988) and the two-stage classification according to Sundell, distinguishing the form associated with enamel hypoplasia and enamel hypomineralization. The aim of this paper is to present the diagnostic and therapeutic management of patients with amelogenesis imperfecta at the developmental age, based on three clinical cases. Three cases were chosen to represent patients with AI: 1) hypoplastic type of AI in 14-year-old girl, 2) hypoplastic type of AI in 12-year-old girl with distoocclusion and retrusion of upper incisors, 3) hypoplastic type of AI in 13-year-old boy with deep overbite and functional retrognathia. Presented methods of treatment were selected depending on the form of lesions, patient’s age and coexisting malocclusion. Direct reconstruction with composite materials was used – free-hand, as well as the technique of indirect reconstruction with steel crowns combined with use of functional orthodontic appliances. Dental treatment in patients with AI should be interdisciplinary. The choice of treatment method depends on the coexisting disorders. It aims to eliminate caries associated with enamel development defects and to correct occlusal conditions, as well as to improve the psychosocial functioning of patients by improving the aesthetics of the teeth.
FUNKCJONOWANIE BUDŻETU OBYWATELSKIEGO W MAŁYCH MIASTACH WOJEWÓDZTWA ŁÓDZKIEGO
Authors: Mikołajczyk Tomasz
Published: February 2024

Budżet obywatelski, zwany także partycypacyjnym, stanowi specyficzną formę partycypacji społecznej, w ramach której mieszkańcy danej jednostki terytorialnej mogą decydować o przeznaczeniu części dostępnych środków publicznych podczas głosowania na zgłoszone projekty obywatelskie. Budżet partycypacyjny swoje początki miał w Polsce w 2011 roku. Od tego czasu coraz więcej polskich miast i gmin wykorzystuje to przedsięwzięcie jako demokratyczny sposób zarządzania środkami publicznymi na poziomie lokalnym, zapewniając faktyczny udział społeczeństwa w procesie decyzyjnym. Celem niniejszej pracy jest diagnoza oraz ocena funkcjonowania budżetu obywatelskiego w małych miastach województwa łódzkiego.
OD NIECHCIANEJ FABRYKI BAWEŁNY DO SYMBOLU MIASTA. EWOLUCJA ZNACZENIA DZIEDZICTWA POPRZEMYSŁOWEGO W ROZWOJU MIASTA
Authors: Wójciki Hubert , Nowakowska Aleksandra
Published: February 2024

Dziedzictwo poprzemysłowe należy do ogromnej „rodziny” dziedzictwa kulturowego. Na to  dziedzictwo składają się głównie materialne elementy pozostałe po kulturze przemysłowej danego regionu.  Dziedzictwo poprzemysłowe posiada wartości historyczne, społeczne, urbanistyczne, naukowe czy techno-  logiczne, w tym dziedzictwie zawarta jest również unikatowa tożsamości regionu. Wiele niepowtarzalnych  elementów dziedzictwa poprzemysłowego obecnych jest dziś w strukturze urbanistycznej Łodzi, tym samym  tworzy jego specyficzność i stanowi istotny czynnik rozwoju.  Jednak ta tendencja widoczna jest zaledwie od dwóch dekad. Pod koniec lat 90. XX wieku stosunek  mieszkańców do tego zasobu był negatywny. Materialne elementy dziedzictwa poprzemysłowego stawały  się problemem bez wartości. Celem niniejszego artykułu jest zaprezentowanie ewolucji zmiany podejścia  lokalnej społeczności do postrzegania dziedzictwa poprzemysłowego Łodzi oraz pokazanie, jak potencjał  dziedzictwa wpłynął na rozwój miasta i na jego wizerunek. Ważnym celem artykułu jest charakterystyka  wykorzystania postindustrialnego dziedzictwa w procesie rewitalizacji Łodzi na przykładzie Manufaktury.  Zastosowana w artykule metoda badawcza to analiza treści prasy lokalnej, której głównym, przedmiotem  jest Manufaktura.  Artykuł pokazuje, jak dziedzictwo poprzemysłowe wpłynęło na wizerunek i rozwój miasta. Ważną częścią  artykułu jest zaprezentowanie wartości dodanych, jakie społeczność lokalna zyskała dzięki rewaloryzacji  swego niepowtarzalnego dziedzictwa poprzemysłowego. Pobudzenie uśpionych wartości, jakie posiadał  obiekt, wpłynęły na zmianę postrzegania dziedzictwa poprzemysłowego, a jego nowe funkcje generują  kolejną zmianę w postrzeganiu tego obiektu. Wnioski z przeprowadzonych badań wskazują również na to,  że dziedzictwo poprzemysłowe Łodzi, jakim jest Manufaktura, stanowi nie tylko świadectwo przeszłości,  ale również jest świadectwem postępu, przemiany po upadku epoki przemysłu włókienniczego. Kluczowym  wnioskiem jest również to, że realizowania inwestycja w murach fabryki Poznańskiego stała się prekursorem i inspiracją do prowadzenia dalszych działań rewitalizacyjnych obiektów pofabrycznych znajdujących się  w krajobrazie miasta.
Enhancement of Seismic Image Based on Novel Approach with Custom U-Net Architecture
Authors: Mammadov O. , Yeleskina T. , Karimli J. , Asgarov H. , Shafiyev A. , Malikov R. , Shahsenov I.
Published: February 2024

This paper introduces an innovative approach for enhancing the vertical resolution of seismic images, augmenting conventional signal processing with deep learning algorithms and modeling techniques. The algorithm outlined in this study is specifically designed to be applicable across diverse datasets, operating independently of well data. It effectively addresses noise reduction, distinguishing geological features from disturbances and by improving the signal-to-noise ratio, and implements enhancements to the frequency spectrum through a nonlinear approach. The research endeavors to create an unconventional methodology, focusing on vertical resolution improvement. Notably, the effectiveness of this approach is demonstrated using real seismic data collected from the South Caspian Basin. Detailed results are presented, underscoring the potential to significantly enhance the accuracy and reliability of seismic exploration procedures in the realm of geophysics.
Esofagite eosinofílica: fisiopatologia, diagnóstico e condutas terapêuticas
Authors: Pagoto Lúcia Friggi , Vasconcelos Lucia Helena Ferreira , Oliveira Danielle Furtado de , Duarte Nathalia Lopez
Published: February 2024

Objetivo: Descrever o quadro clínico, o diagnóstico e o tratamento de pacientes portadores de esofagite eosinofílica. Revisão bibliográfica: A esofagite eosinofílica (EoE) é uma doença alérgica crônica, de etiologia multifatorial, mediada por citocinas Th2. O paciente apresenta diversos sintomas tais como pirose, regurgitação, vômitos, impactação alimentar e disfagia, sendo eles comuns a outras enfermidades. Além das manifestações clínicas, a endoscopia digestiva alta com realização de biópsia é importante para o diagnóstico. O diagnóstico e tratamento precoces são fundamentais para evitar possíveis complicações da doença. O tratamento da EoE vem progredindo, sendo a terapia farmacológica, dietética e a terapia com dilatação endoscópica as terapêuticas disponíveis atualmente no mercado. Considerações finais: A esofagite eosinofílica é uma doença complexa e facilmente confundida com outras patologias de clínica semelhante, o que pode influenciar no atraso de seu diagnóstico. Assim, é importante o devido conhecimento sobre essa condição a fim de iniciar o tratamento de maneira precoce, reduzindo as chances de progressão da doença, com consequente menor sintomatologia e melhor qualidade de vida.
Optimization of Chromium (VI) Adsorption using Microalgae Biomass (Spirulina sp.) and its Application in Leather Tannery Waste
Authors: Adetya Nais Pinta , Arifin Uma Fadzilia , Anggriyani Emiliana , Rachmawati Laili
Published: February 2024

This study was conducted to examine the adsorption of Cr (VI) metal using Spirulina sp (inactive) biomass and its application in leather tannery wastewater. The treatment was carried out to determine the influence of independent variables on Cr (VI) adsorption with variations in pH, contact time, and metal solution concentration. The values of the solution pH, adsorption time, and concentration of the best metal solution were used to determine the center points of the optimization variables through Response Surface Methodology (RSM). The results showed that based on the FTIR test, macromolecules present in Spirulina sp biomass included amino, carboxylate, and hydroxy groups. The combination of factor variables that produced the optimum response was at pH 3.165, contact time of 66.58 minutes, and Cr (VI) metal ion solution concentration of 22.9 mg/L, resulting in a Cr (VI) adsorption efficiency of 69.66%. The adsorption pattern was included in the Freundlich adsorption isotherm, and the application of Spirulina sp biomass adsorbent to tannery waste reduced the concentration of Cr (VI) from 3.9 g/L to an undetectable level at <1.4 g/L.
In situ/In vivo Optical Microspectroscopy to Probe the Emergence of Morphology
Authors: Barbosa Natercia , Urquidi Oscar , Brazard Johanna , Adachi Takuji B. M.
Published: February 2024

Morphology governs function. Yet, understanding and controlling the emergence of morphology at the molecular level remains challenging. The difficulty in studying the early stage of morphology formation is due to its stochastic nature both spatially and temporally occurring at the nanoscale. This nature has been particularly detrimental for the application of optical spectroscopy. To overcome this problem, we have been developing new in situ/in vivo optical spectroscopy tools, which are label-free and non-invasive. This account highlights several examples of how optical spectroscopy can become an important tool in studying the birth of morphology.
ИССЛЕДОВАНИЕ РАЗЛИЧИЙ МЕЖДУ КИТАЙСКОЙ ПЕЙЗАЖНОЙ ЖИВОПИСЬЮ И РУССКОЙ ПЕЙЗАЖНОЙ ЖИВОПИСЬЮ МАСЛОМ
Authors: Дин С. , Чжао С.
Published: February 2024

Китайская пейзажная живопись и русская пейзажная живопись маслом, будучи выдающимися представителями своих культур, передают глубокие размышления о жизни, философии и человеческих эмоциях через выражение природных пейзажей. Цель данной диссертации - выявить их уникальность в культурном и эстетическом выражении через анализ их исторических истоков, культурных традиций и художественных особенностей, а затем раскрыть уникальное понимание природы, жизни и Вселенной в китайской и русской культурных традициях, что дает полезные ориентиры для понимания и уважения мультикультурализма.
جودة حياة أسر الأشخاص ذوي الإعاقة الحسية: المشكلات وآليات التكيف
Authors: الغامدي سماهر أحمد , القرشي ريهام حسن , القحطاني رجاء طه
Published: February 2024

الأسرة اللبنة الأساسية التي تقوم عليها المجتمعات، ولكن قد تواجه تحديات كوجود شخص من ذوي الإعاقة مما يجب عليها مواجهة هذه التحديات والتكيف معها. وتسعى الدراسة إلى الكشف عن المشكلات التي تواجه أسر ذوي الإعاقة، والتعرف على آليات تكيف الأسر مع المشكلات. حللت الدراسة المشكلات وآليات التكيف بالاستعانة بنظرية الدور، ونظرية الوصمة. واعتمدت الدراسة المنهج المزجي باستخدام الاستبانة الالكترونية لـ (125) أسرة والمقابلات شبه المقننة لـ (9) من أسر ذو الإعاقة. يتكون مجتمع الدراسة من أسر ذوي الإعاقات الحسية (سمعية وبصرية)، عينة الدراسة تتكون من (125) أسرة لديها فرد أو أكثر من ذوي الإعاقة الحسية (سمعية أو بصرية) تم الاعتماد على مواقع التواصل الاجتماعي (واتس آب، وتليجرام، وتويتر) لنشر الاستبانة الالكترونية للوصول إلى العينة المطلوبة. واستنتجت الدراسة: أن وجود شخص من ذوي الإعاقة يزيد من تقارب أفراد الأسرة وتعاونها، بدأت الأسرة مباشرة بالعلاج عند معرفتها بإصابة أحد أفرادها بالإعاقة، لا تواجه الأسرة مشكلات مجتمعية في ظل وجود الشخص ذو الإعاقة، لا يوجد مشكلات نفسية بسبب وجود شخص ذو إعاقة، يعامل الشخص ذو الإعاقة بشكل عادي كبقية أفراد الأسرة. ترى الأسرة أن إصابة أحد أفرادها بالإعاقة منحة من الله يصطفي الله بها عباده الصابرين. أهم المشكلات التي تواجه أسر ذوي الإعاقة هي: قصور الخدمات في الأماكن العامة، عدم وجود جهة محددة تقدم التوعية للأسر بحقوق وخدمات الأشخاص ذوي الإعاقة، أن رعاية شخص ذو إعاقة تسبب الكثير من الضغط النفسي، أن تكاليف علاج الشخص ذو الإعاقة تشكل عبء مالي على الأسرة، أن الدعم المالي المقدم لذوي الإعاقة لا يكفي احتياجاته، ترى الأسرة أن جمعيات ذوي الإعاقة لا توفر جميع المتطلبات التعليمية لهم. أبرز آليات التكيف مع المشكلات هي: أن الأسرة في بحث دائم على العلاجات الطبية الحديثة لمواجهة مشكلة الشخص ذو الإعاقة، تعامل الأسرة ذو الإعاقة بمساواة ودون تحيز، الأسرة تشعر بالرضا ومتكيفة مع وجود ذوي الإعاقة، استفادة الأسرة من الإعانة التعليمة المقدمة للشخص ذي الإعاقة.
ANALISIS STUDI PENELUSURAN (TRACER STUDY) ALUMNI PROGRAM STUDI MAGISTER PENDIDIKAN EKONOMI FAKULTAS KEGURUAN DAN ILMU PENDIDIKAN UNIVERSITAS TANJUNGPURA
Authors: Mandala Yoga , Asriati Nuraini , Syamsuri Syamsuri
Published: February 2024

This study aims to examine and analyze Educational History, Employment history, competence and competitiveness, relevance of education and work, learning experiences of alumni of the master of economic education study program FKIP Untan. This form of research is quantitative descriptive research with a type of Survey research. The samples in this study were graduates of TS-2 to TS master's study program in Economic Education FKIP Untan with a total of 13 alumni. The sampling method is Total Sampling. Data were collected with questionnaires that had been tested for validity by experts. The results of this study show that the Educational History based on the GPA of alumni is entirely >3.00, the waiting period for alumni work is on average 2-2.5 years, in filling the waiting period for the work of trade alumni, entrepreneurs, honoraries and others. Alumni work history is Most alumni work as teachers / educators in private and public schools with a salary of >Rp1,000,000 to Rp5,000,000, this job is obtained through the internet or connection (friends and family) actively searching for themselves. The competence and competitiveness of alumni measured by various competencies have been considered good, the relevance of education and work is considered to be relevant between education and work, the contribution of learning experience in the master's study program economic education is largely very important in the world of work.
Cytogenetic and Molecular Remission in Chronic Myeloid Leukemia in Togo
Authors:   Department of Hematology, University of Lomé, Togo, E Padaro , KMC Womey ,   Department of Hematology, University of Lomé, Togo, Y Layibo ,   Laboratory of Hematology, University of Lomé, Togo, MDI Kueviakoe ,   Laboratory of Hematology, University of Lomé, Togo, H Magnang ,   Department of Hematology, University of Lomé, Togo, K Mawussi ,   Kara Regional Blood Transfusion Center, University of Kara, Togo, K Agbetiafa ,   Department of Hematology, University of Lomé, Togo, KS Agbado ,   Department of Hematology, University of Lomé, Togo, A Vovor ,   Laboratory of Hematology, University of Lomé, Togo
Published: February 2024

The availability of tyrosine kinase inhibitors (TKIs) in Togo through the GIPAP program has revolutionized the management of chronic myeloid leukemia and increased patient life expectancy. However, diagnosis and molecular monitoring of therapeutic efficacy remain a real challenge due to the inaccessibility of cytogenetic and molecular biology tools. We’ve conducted, a cross-sectional, descriptive study that ran from December 21, 2022, to January 20, 2023, with the aim to evaluate the cytogenetic and molecular remission in CML patients followed at the CHU Campus de Lomé in Togo. Patients diagnosed with chronic-phase CML who had been treated for at least three months with imatinib or dasatinib and had achieved complete hematological remission were included. Dosage of BCR-ABL transcript levels was performed by RQ-PCR in Seattle, USA, using Dried Blood Spot. The transcript detection limit was 0.003% i.e., MR4. A total of 38 patients were included, 68.4% of them were treated with imatinib and 31.6% with dasatinib. In terms of remission, 28.9% had not achieve a partial cytogenetic remission while 15.8% of patients had achieved a MR4 remission and 7.9% a major molecular remission. Major molecular remission was achieved at a mean follow-up time of 95 months for patients taking imatinib and 22 months for those taking dasatinib. Patients in MR4 were on imatinib after a mean of 68 months. All in one, our study showed a high rate of treatment failure. Better access to cytogenetic and molecular biology tools is needed to improve management.
Pressure-driven batch distillation optimal control for acetone-methanol separation
Authors: Stojkovic Marija
Published: February 2024

Over the last fifteen years, immense progress has been made in the research of pressure-swing batch distillation. The challenge lies in the fact that certain pressure-sensitive azeotropic mixtures cannot be separated in a regular open batch mode, with an acceptable outcome. Throughout most of this text, findings are to contradict previously grounded facts. Acetone-methanol separation by pressure-swing batch distillation in a mixed double system consisting of a regular and inverted double column is a process under investigation. In this work, a complete global solution to the optimal control problem in form of a sequential synthesis of controlled trajectories is derived. During this study, the optimal reflux strategy through cyclic operation was extended to the separation of a non-ideal minimum boiling azeotrope of industrial significance. The influence of the liquid ratio and tank volume on the control pattern and energy requirement is evaluated as well.
Kinetic Resolution Polymerization Enabled Chemical Synthesis of Perfectly Isotactic Polythioesters
Authors: Li Kun , Cheng Jing-Liang , Wang Meng-Yuan , Xiong Wei , Huang Hao-Yi , Feng Liang-Wen , Cai Zhongzheng , Zhu Jian-Bo
Published: February 2024

Isotactic polythioesters (PTEs) that were thioester analogs to polyhydroxyalkanoates (PHAs) has attracted growing atten-tion due to their distinct properties. However, the development of chemically synthetic methods to prepare isotactic PTEs has long been an intricate endeavor. Herein, we report the successful synthesis of a perfectly isotactic PTE via stereocon-trolled ring-opening polymerization. This binaphthalene-salen alumnium (SalBinam-Al) catalyst promoted a robust polymerization of rac-α-substituted-β-propiothiolactones (rac-BTL and rac-PTL) with highly kinetic resolution and afforded perfectly isotactic P(BTL) and P(PTL) with Mn up to 276 kDa. More impressively, the isotactic P(BTL) contributed to form-ing a supramolecular stereocomplex with improved thermal property of Tm = 204 °C. Ultimately, this kinetic resolution polymerization enabled the facile isolation of enantiopure (S)-BTL, which could efficiently convert to an important phar-maceutical building block (S)-2-benzyl-3-mercapto-propanoic acid. Isotactic P(PTL) served as a tough and ductile material comparable to the commercialized polyolefins. This synthetic system allowed to access of isotactic PTEs, establishing a powerful platform for the discovery of sustainable plastics.
Effects of the Y432S Cancer-Associated Variant on the Reaction Mechanism of Human DNA Polymerase κ
Authors: Maghsoud Yazdan , Roy Arkanil , Leddin Emmett M. , Cisneros G. Andrés
Published: February 2024

Human polymerases are vital for genetic information management. Their function involves catalyzing the synthesis of DNA strands with unparalleled accuracy, which ensures the fidelity and stability of the human genomic blueprint. Several disease-associated mutations and their functional impact on DNA polymerases have been reported. One particular polymerase, human DNA polymerase kappa (Pol κ), has been reported to be susceptible to several cancer-associated mutations. The Y432S mutation in Pol κ, which is associated with various cancers, is of interest due to its impact on polymerization activity and markedly reduced thermal stability. Here, we have used computational simulations to investigate the functional consequences of the Y432S by means of classical molecular dynamics (MD) and coupled quantum mechanics/molecular mechanics (QM/MM) methods. Our results suggest that Y432S results in structural effects on domains involved in nucleotide addition and ternary complex stabilization while maintaining catalytic competence. Calculation of the minimum energy path associated with the reaction mechanism of wild type (WT) and Y432S Pol κ indicate that while both enzymes are catalytically competent, the cancer mutation results in a slightly endoergic reaction and an increase in the catalytic barrier. Interactions with a third magnesium ion and environmental effects on non-bonded interactions, particularly involving key residues, contribute to the kinetic and thermodynamic distinctions between the WT and mutant during the catalytic reaction. The energetics and electronic findings suggest that active site residues favor the catalytic reaction with dCTP3– over dCTP4–.
PROSAC as a selection tool for SO-PLS regression: a strategy for multi-block data fusion
Authors: Diaz-Olivares Jose Antonio , Bendoula Ryad , Saeys Wouter , Ryckewaert Maxime , Adriaens Ines , Fu Xinyue , Pastell Matti , Roger Jean-Michel , Aernouts Ben
Published: February 2024

Spectral data from multiple sources can be integrated into multi-block fusion chemometric models, such as sequentially orthogonalized partial-least squares (SO-PLS), to improve the prediction of sample quality features. Pre-processing techniques are often applied to mitigate extraneous variability, unrelated to the response variables. However, the selection of suitable pre-processing methods and identification of informative data blocks becomes increasingly complex and time-consuming when dealing with a large number of blocks. The problem addressed in this work is the efficient pre-processing, selection and ordering of data blocks for targeted applications in SO-PLS. We introduce the PROSAC-SO-PLS methodology, which employs pre-processing ensembles with response-oriented sequential alternation calibration (PROSAC). This approach identifies the best pre-processed data blocks and their sequential order for specific SO-PLS applications. The method uses a stepwise forward selection strategy, facilitated by the rapid Gram-Schmidt process, to prioritize blocks based on their effectiveness in minimizing prediction error, as indicated by the lowest prediction residuals. To validate the efficacy of our approach, we showcase the outcomes of three empirical near-infrared (NIR) datasets. Comparative analyses were performed against partial-least-squares (PLS) regressions on single-block pre-processed datasets and a methodology relying solely on PROSAC. The PROSAC-SO-PLS approach consistently outperformed these methods, yielding significantly lower prediction errors. This has been evidenced by a reduction in the root-mean-squared error of prediction (RMSEP) ranging from 5 to 25% across seven out of the eight response variables analyzed. The PROSAC-SO-PLS methodology offers a versatile and efficient technique for ensemble pre-processing in NIR data modeling. It enables the use of SO-PLS minimizing concerns about pre-processing sequence or block order and effectively manages a large number of data blocks. This innovation significantly streamlines the data pre-processing and model-building processes, enhancing the accuracy and efficiency of chemometric models.
Chemically Recyclable, High Molar Mass Polyoxazolidinones via Ring Opening Metathesis Polymerization
Authors: Pal Arpan , Wong Allison , Lamb Jessica
Published: February 2024

The development of robust methods for the synthesis of chemically recyclable polymers with tunable properties is necessary for the design of next-generation materials. Polyoxazolidinones (POxa) – polymers with five-membered urethanes in their backbones – are an attractive target because they are strongly polar and have high thermal stability, but existing step-growth syntheses limit molar masses and chemical recyclability to monomer is rare. Herein, we report the synthesis of high molar mass POxa via ring opening metathesis polymerization of oxazolidinone-fused cyclooctenes. These novel polymers show <5% mass loss up to 382–411 °C and have tunable glass transition temperatures (14–56 °C) controlled by side chain structure. We demonstrate facile chemical recycling to monomer and re-polymerization despite moderately high monomer ring strain energies, which we hypothesize is facilitated by the conformational restriction introduced by the fused oxazoli-dinone ring. This method represents the first chain growth synthesis of POxa and provides a versatile platform for the study and application of this emerging subclass of polyurethanes.
Aging of Environmentally Friendly Alkyd Coating Containing Tinuvin 292 under Effect of UV Radiation
Authors: Nguyen Trung Thanh
Published: February 2024

This study presents durability of environmentally friendly alkyd coating containing Tinuvin 292 (a liquid hindered amine light stabilizer) under UV-thermo-humidity condition. Coatings were accelerated under UV-thermo-humidity complex for 100 cycles. FT-IR, TGA and SEM were used to value the changes of before and after accelerated weathering tested coatings. Results showed that gloss loss, adhesion, flexural strength, impact resistance, relative hardness of tested coating were much improved with 1.5 weight percent (wt.%) of Tinuvin 292. FT-IR spectrums of initial and aged coatings without Tinuvin 292 illustrated the significant changes on intensity of CH2 and C=O (ester) groups. Meanwhile, coating with Tinuvin 292 exhibited that intensity of CH2 and ester groups had been changed slightly. SEM images indicated that surface morphology of samples changed differently depending on the presence Tinuvin 292. After aging process, surface of aged coating without Tinuvin 292 became worse than that of coating with Tinuvin 292. TGA also showed that 1.5 wt.% of Tinuvin 292 had improved thermo oxidation stability of environmentally friendly coating.