bluuebunny/crossref_metadata_2025 huggingface dataset:
The acidic tumor microenvironment drives a stem-like phenotype in melanoma cells
Authors: Andreucci Elena , Peppicelli Silvia , Ruzzolini Jessica , Bianchini Francesca , Biagioni Alessio , Papucci Laura , Magnelli Lucia , Mazzanti Benedetta , Stecca Barbara , Calorini Lido
Published: August 2020

Acidosis characterizes the microenvironment of most solid tumors and is considered a new hallmark of cancer. It is mainly caused by both “aerobic” and “anaerobic” glycolysis of differently adapted cancer cells, with the final product lactic acid being responsible of the extracellular acidification. Many evidences underline the role of extracellular acidosis in tumor progression. Among the different findings, we demonstrated that acidosis-exposed cancer cells are characterized by an epithelial-to-mesenchymal transition phenotype with high invasive ability, high resistance to apoptosis, anchorage-independent growth, and drug therapy. Acidic melanoma cells over-express SOX2, which is crucial for the maintenance of their oxidative metabolism, and carbonic anhydrase IX, that correlates with poor prognosis of cancer patients. Considering these evidences, we realized that the profile outlined for acid cancer cells inevitably remind us the stemness profile. Therefore, we wondered whether extracellular acidosis might induce in cancer cells the acquisition of stem-like properties and contribute to the expansion of the cancer stem cell sub-population. We found that a chronic adaptation to acidosis stimulates in cancer cells the expression of stem-related markers, also providing a high in vitro/in vivo clonogenic and trans-differentiating ability. Moreover, we observed that the acidosis-induced stem-like phenotype of melanoma cells was reversible and related to the EMT induction. These findings help to characterize a further aspect of stem cell niche, contributing to the sustainment and expansion of cancer stem cell subpopulation. Thus, the usage of agents controlling tumor extracellular acidosis might acquire great importance in the clinic for the treatment of aggressive solid tumor.

Key messages

• Extracellular acidosis up-regulates EMT and stem-related markers in melanoma cells

• Acidic medium up-regulates in vitro self-renewal capacity of melanoma cells

• Chronic acidosis adaptation induces trans-differentiation ability in melanoma cells

• Melanoma cells adapted to acidosis show higher tumor-initiating potential than control cells

• Extracellular acidosis promotes a stem-like phenotype in prostate and colorectal carcinoma cells
Causal Reasoning and Meno’s Paradox
Authors: Chen Melvin , Chew Lock Yue
Published: August 2020

Causal reasoning is an aspect of learning, reasoning, and decision-making that involves the cognitive ability to discover relationships between causal relata, learn and understand these causal relationships, and make use of this causal knowledge in prediction, explanation, decision-making, and reasoning in terms of counterfactuals. Can we fully automate causal reasoning? One might feel inclined, on the basis of certain groundbreaking advances in causal epistemology, to reply in the affirmative. The aim of this paper is to demonstrate that one still has good skeptical grounds for resisting any conclusions in favour of the automation of causal reasoning. If by causal reasoning is meant the entirety of the process through which we discover causal relationships and make use of this knowledge in prediction, explanation, decision-making, and reasoning in terms of counterfactuals, then one relies besides on tacit knowledge, as might be constituted by or derived from the epistemic faculty virtues and abilities of the causal reasoner, the value systems and character traits of the causal reasoner, the implicit knowledge base available to the causal reasoner, and the habits that sustain our causal reasoning practices. While certain aspects of causal reasoning may be axiomatized and formalized and algorithms may be implemented to approximate causal reasoning, one has to remain skeptical about whether causal reasoning may be fully automated. This demonstration will involve an engagement with Meno’s Paradox.
The outcomes of stand alone polyetheretherketone cages in anterior cervical discectomy and fusion
Authors: Ahmed Abdulaziz F. , Al Dosari Mohammed Al Ateeq , Al Kuwari Abdulaziz , Khan Nasser Mehrab
Published: August 2020

The procedure of anterior cervical discectomy and fusion is considered as the treatment of choice in degenerative disc disease, which material provides the best clinical and radiological fusion and other outcomes remains heavily debated. Materials that augment the process of fusion consist of bone grafting, titanium, polyetheretherketone (PEEK), or carbon cages. The application of PEEK cages has been recommended as it is radiolucent, and it has a modulus of elasticity that is similar to cortical bone. PEEK cages can be either filled with various materials or unfilled cages. Filled PEEK cages can include bone autografts, bone allografts, demineralized bone matrix, and other materials that facilitate fusion. This narrative review highlights that standalone filled PEEK cages were likely to have better radiological outcomes and satisfactory clinical outcomes for myelopathy when compared with standalone unfilled PEEK cages.
Formation of half-period surface relief gratings in azobenzene containing polymer films
Authors: Jelken Joachim , Henkel Carsten , Santer Svetlana
Published: August 2020

We study the peculiar response of photo-sensitive polymer films irradiated with a certain type of interference pattern where one interfering beam is S-polarized, while the second one is P-polarized. The polymer film, although in a glassy state, deforms following the local polarization distribution of the incident light, and a surface relief grating (SRG) appears whose period is half the optical one. All other types of interference patterns result in the matching of both periods. The topographical response is triggered by the alignment of photo-responsive azobenzene containing polymer side chains orthogonal to the local electrical field, resulting in a bulk birefringence grating (BBG). We investigate the process of dual grating formation (SRG and BBG) in a polymer film utilizing a dedicated set-up that combines probe beam diffraction and atomic force microscopy (AFM) measurements, and permits acquiring in situ and in real-time information about changes in local topography and birefringence. We find that the SRG maxima appear at the positions of linearly polarized light (tilted by 45° relative to the grating vector), causing the formation of the half-period topography. This permits to inscribe symmetric and asymmetric topography gratings with sub-wavelength period, while changing only slightly the polarization of one of the interfering beams. We demonstrate an easy generation of sawtooth profiles (blazed gratings) with adjustable shape. With these results, we have taken a significant step in understanding the photo-induced deformation of azo-polymer films.
Controlling orientation, conformation, and biorecognition of proteins on silane monolayers, conjugate polymers, and thermo-responsive polymer brushes: investigations using TOF-SIMS and principal component analysis
Authors: Gajos Katarzyna , Awsiuk Kamil , Budkowski Andrzej
Published: August 2020

Control over orientation and conformation of surface-immobilized proteins, determining their biological activity, plays a critical role in biointerface engineering. Specific protein state can be achieved with adjusted surface preparation and immobilization conditions through different types of protein-surface and protein-protein interactions, as outlined in this work. Time-of-flight secondary ion mass spectroscopy, combining surface sensitivity with excellent chemical specificity enhanced by multivariate data analysis, is the most suited surface analysis method to provide information about protein state. This work highlights recent applications of the multivariate principal component analysis of TOF-SIMS spectra to trace orientation and conformation changes of various proteins (antibody, bovine serum albumin, and streptavidin) immobilized by adsorption, specific binding, and covalent attachment on different surfaces, including self-assembled monolayers on silicon, solution-deposited polythiophenes, and thermo-responsive polymer brushes. Multivariate TOF-SIMS results correlate well with AFM data and binding assays for antibody-antigen and streptavidin-biotin recognition. Additionally, several novel extensions of the multivariate TOF-SIMS method are discussed.

Graphical abstract
Nitric oxide interacts with cholinoceptors to modulate insulin secretion by pancreatic β cells
Authors: Mussa Bashair M. , Srivastava Ankita , Mohammed Abdul Khader , Verberne Anthony J. M.
Published: August 2020

Dysfunction of the pancreatic β cells leads to several chronic disorders including diabetes mellitus. Several mediators and mechanisms are known to be involved in the regulation of β cell secretory function. In this study, we propose that cytokine-induced nitric oxide (NO) production interacts with cholinergic mechanisms to modulate insulin secretion from pancreatic β cells. Using a rat insulinoma cell line INS-1, we demonstrated that β cell viability decreases significantly in the presence of SNAP (NO donor) in a concentration- and time-dependent manner. Cell viability was also found to be decreased in the presence of a combined treatment of SNAP with SMN (muscarinic receptor antagonist). We then investigated the impact of these findings on insulin secretion and found a significant reduction in glucose uptake by INS-1 cells in the presence of SNAP and SMN as compared with control. Nitric oxide synthase 3 gene expression was found to be significantly reduced in response to combined treatment with SNAP and SMN suggesting an interaction between the cholinergic and nitrergic systems. The analysis of gene and protein expression further pin-pointed the involvement of M3 muscarinic receptors in the cholinergic pathway. Upon treatment with cytokines, reduced cell viability was observed in the presence of TNF-α and IFN-γ. A significant reduction in insulin secretion was also noted after treatment with TNF-α and IFN-γ and IL1-β. The findings of the present study have shown for the first time that the inhibition of the excitatory effects of cholinergic pathways on glucose-induced insulin secretion may cause β cell injury and dysfunction of insulin secretion in response to cytokine-induced NO production.
Role of c-Fos in orthodontic tooth movement: an in vivo study using transgenic mice
Authors: Decker Maximilian G. , Nottmeier Cita , Luther Julia , Baranowsky Anke , Kahl-Nieke Bärbel , Amling Michael , Schinke Thorsten , David Jean-Pierre , Koehne Till
Published: August 2020

Objectives

The transcription factor c-Fos controls the differentiation of osteoclasts and is expressed in periodontal ligament cells after mechanical stimulation in vitro. However, it is unclear how c-Fos regulates orthodontic tooth movement (OTM) in vivo. The aim of this study was therefore to analyse OTM in transgenic mice with overexpression of c-Fos.

Materials and methods

We employed c-Fos transgenic mice (c-Fos tg) and wild-type littermates (WT) in a model of OTM induced by Nitinol tension springs that were bonded between the left first maxillary molars and the upper incisors. The unstimulated contralateral side served as an internal control. Mice were analysed by contact radiography, micro-computed tomography, decalcified histology and histochemistry.

Results

Our analysis of the unstimulated side revealed that alveolar bone and root morphology were similar between c-Fos tg and control mice. However, we observed more osteoclasts in the alveolar bone of c-Fos tg mice as tartrate-resistant acid phosphatase (TRAP)-positive cells were increased by 40%. After 12 days of OTM, c-Fos tg mice exhibited 62% increased tooth movement as compared with WT mice. Despite the faster tooth movement, c-Fos tg and WT mice displayed the same amount of root resorption. Importantly, we did not observe orthodontically induced tissue necrosis (i.e. hyalinization) in c-Fos tg mice, while this was a common finding in WT mice.

Conclusion

Overexpression of c-Fos accelerates tooth movement without causing more root resorption.

Clinical relevance

Accelerated tooth movement must not result in more root resorption as higher tissue turnover may decrease the amount of mechanically induced tissue necrosis.
Molecular typing tools for identifying and characterizing lactic acid bacteria: a review
Authors: Sharma Anshul , Lee Sulhee , Park Young-Seo
Published: August 2020

Identification and classification of beneficial microbes is of the highest significance in food science and related industries. Conventional phenotypic approaches pose many challenges, and they may misidentify a target, limiting their use. Genotyping tools show comparatively better prospects, and they are widely used for distinguishing microorganisms. The techniques already employed in genotyping of lactic acid bacteria (LAB) are slightly different from one another, and each tool has its own advantages and disadvantages. This review paper compiles the comprehensive details of several fingerprinting tools that have been used for identifying and characterizing LAB at the species, sub-species, and strain levels. Notably, most of these approaches are based on restriction digestion, amplification using polymerase chain reaction, and sequencing. Nowadays, DNA sequencing technologies have made considerable progress in terms of cost, throughput, and methodology. A research journey to develop improved versions of generally applicable and economically viable tools for fingerprinting analysis is ongoing globally.
Age structure in a newly established and increasing population: initially high proportion of young birds among nesting Great Grey Owls
Authors: Sonerud Geir A. , Solheim Roar , Berg Trond
Published: August 2020

The mechanisms behind expansions of the distribution of a bird species and the ensuing establishment of new populations are poorly known. The distribution of Great Grey Owl (Strix nebulosa) in the western Palearctic has generally expanded towards southwest during the past fifty years, and particularly so in Fennoscandia. In the past decade, the recorded breeding population in Norway, confined to Hedmark county bordering Sweden, increased from 1 pair in 2009 to > 100 pairs in 2017–2018, extending the southwestern border of the distribution > 100 km. We studied the age structure of this expanding population based on the molting pattern of the wing feathers of birds captured at the nest site for banding and of non-captured birds photographed in flight. In Fennoscandia the Great Grey Owl relies on shrews and microtine rodents, which usually fluctuate in 3–4 years cycles. The proportion of 1-year old birds among the nesting Great Grey Owls was higher in peak year two of each small mammal population cycle (2011, 2014 and 2018) than in peak year one (2010, 2013 and 2017), and was particularly high (77%) in 2011 when the owl population was far lower (22 nestings recorded) than in later corresponding years (64 nestings in 2014 and 103 in 2018). Thus, this population seems to have been founded to a large extent by birds nesting as 1 year olds, and most likely having dispersed from Sweden. The ability to determine the age of Great Grey Owls without having to capture them extended our data set, in particular for males, which are more reluctant to attack intruders at the nest site and, therefore, less likely to be captured for banding. Being able to age a bird without having to capture it is important, because trapping does not sample a bird population randomly.
A Review of Portable High-Performance Liquid Chromatography: the Future of the Field?
Authors: Rahimi Faraz , Chatzimichail Stelios , Saifuddin Aliyah , Surman Andrew J. , Taylor-Robinson Simon D. , Salehi-Reyhani Ali
Published: August 2020

There is a growing need for chemical analyses to be performed in the field, at the point of need. Tools and techniques often found in analytical chemistry laboratories are necessary in performing these analyses, yet have, historically, been unable to do so owing to their size, cost and complexity. Technical advances in miniaturisation and liquid chromatography are enabling the translation of these techniques out of the laboratory, and into the field. Here we examine the advances that are enabling portable liquid chromatography (LC). We explore the evolution of portable instrumentation from its inception to the most recent advances, highlighting the trends in the field and discussing the necessary criteria for developing in-field solutions. While instrumentation is becoming more capable it has yet to find adoption outside of research.
The importance of habitat diversity and plant species richness for hazel grouse occurrence in the mixed mountain forests of the Western Carpathians
Authors: Matysek Marcin , Gwiazda Robert , Bonczar Zbigniew
Published: August 2020

Hazel grouse habitat requirements are relatively well known in coniferous forests, and less known in mixed or deciduous forests. We studied habitat differences between sites occupied by hazel grouse Tetrastes bonasia and control plots in mixed mountain forests of the Western Carpathians in 2009 and 2010. Hazel grouse presence at sites was determined in April and May. The habitat variables (n = 21) and the proportion of tree and shrub species (n = 22) were collected both in sites of hazel grouse presence and control plots within a radius of 100 m. Greater numbers of tree species and greater proportions of deciduous trees (mainly birch Betula sp.) were found in sites where hazel grouse was present. Lower canopy cover was an important variable for hazel grouse occurrence, and sites with hazel grouse had a greater proportion of young trees (< 40 years). Sites were also characterized by a higher proportion of overgrown glades and dead woods in comparison with control plots. Sites occupied by hazel grouse were characterized by a greater number of tree species in the undergrowth (minimum of five species) in comparison with control plots. GLM models revealed that the most important environmental factors for hazel grouse occurrence in mixed mountain forests were open habitats (overgrown glades), good hiding opportunities (fallen trees and dead woods) and good conditions for foraging (trees cover in undergrowth). Poplar (Populus sp.) and willow (Salix sp.) were the most important tree species for hazel grouse occurrence. The presence of habitat structures and the vegetations richness provides good shelter or food for the hazel grouse. Extensive forest management should be proposed to increase the number of hazel grouse. Large areas covered by herbs and light-seeded tree species of low economical value for forestry are recommended to support hazel grouse population.
Standards for the performance assessment of territorial landslide early warning systems
Authors: Piciullo Luca , Tiranti Davide , Pecoraro Gaetano , Cepeda Jose Mauricio , Calvello Michele
Published: August 2020

Landslide early warning systems (LEWS) can be categorized into two groups: territorial and local systems. Territorial landslide early warning systems (Te-LEWS) deal with the occurrence of several landslides in wide areas: at municipal/regional/national scale. The aim of such systems is to forecast the increased probability of landslide occurrence in a given warning zone. The performance evaluation of such systems is often overlooked, and a standardized procedure is still missing. This paper describes a new Excel user-friendly tool for the application of the EDuMaP method, originally proposed by (Calvello and Piciullo 2016). A description of indicators used for the performance evaluation of different Te-LEWS is provided, and the most useful ones have been selected and implemented into the tool. The EDuMaP tool has been used for the performance evaluation of the “SMART” warning model operating in Piemonte region, Italy. The analysis highlights the warning zones with the highest performance and the ones that need threshold refinement. A comparison of the performance of the SMART model with other models operating in different Te-LEWS has also been carried out, highlighting critical issues and positive aspects. Lastly, the SMART performance has been evaluated with both the EDuMaP and a standard 2 × 2 contingency table for comparison purposes. The result highlights that the latter approach can lead to an imprecise and not detailed assessment of the warning model, because it cannot differentiate among the levels of warning and the variable number of landslides that may occur in a time interval.
Between a bog and a hard place: a global review of climate change effects on coastal freshwater wetlands
Authors: Grieger Rebekah , Capon Samantha J. , Hadwen Wade L. , Mackey Brendan
Published: August 2020

Coastal wetlands are significant components of the coastal landscape with important roles in ecosystem service provision and mitigation of climate change. They are also likely to be the system most impacted by climate change, feeling the effects of sea levels rise, temperature increases and rainfall regime changes. Climate change impacts on estuarine coastal wetlands (mangroves, saltmarsh) have been thoroughly investigated; however, the impacts on coastal freshwater wetlands (CFWs) are relatively unknown. To explore the current knowledge of the impacts of climate change on CFWs globally, we undertook a systematic quantitative literature review of peer-reviewed published literature. We found surprisingly little research (110 papers of an initial 678), the majority of which was conducted in the USA, focusing on the effects of sea level rise (SLR) on CFW vegetation or sediment accretion processes. From this research, we know that SLR will lead to reduced productivity, reduced regeneration, and increased mortality in CFW vegetation but little is known regarding the effects of other climate change drivers. Sediment accretion is also not sufficient to keep pace with SLR in many CFWs and again the effects of other climate drivers have not been investigated. The combination of unhealthy vegetation communities and minimal gain in vertical elevation can result in a transition towards a vegetation community of salt-tolerant species but more research is required to understand this process.
Next-generation technologies applied to age-old challenges in Madagascar
Authors: Blanco Marina B. , Greene Lydia K. , Rasambainarivo Fidisoa , Toomey Elizabeth , Williams Rachel C. , Andrianandrasana Lanto , Larsen Peter A. , Yoder Anne D.
Published: August 2020

Madagascar is a biodiversity hotspot that is facing rapid rates of deforestation, habitat destruction, and poverty. Urgent action is required to document the status of biodiversity to facilitate efficacious conservation plans. With the recent advent of portable and affordable genetic technologies, it is now possible to take genomic approaches out of the lab and into the field. Mobile genetics labs can produce scientifically reproducible data under field conditions, dramatically minimizing the time between sample collection and data analysis. Here, we show “proof of concept” by deploying miniPCR bio’s miniaturized thermal cycler alongside Oxford Nanopore’s MinION DNA sequencer in Madagascar. Specifically, we deployed this technology at Anjajavy, northwestern Madagascar for rapid biodiversity assessment. We successfully extracted mouse lemur DNA, amplified and sequenced a phylogenetically informative mitochondrial gene (cytochrome-b; cytb), and thereby confirmed the presence of Danfoss’ mouse lemur (M. danfossi) within the Anjajavy Reserve. We show that a mobile genetics lab can provide expeditious results, and allow scientists to conduct genetic analyses, potentially allowing for rapid interventions under emergency conditions in situ. Additionally, mobile labs offer powerful training opportunities for in-country scientists for whom training opportunities were previously confined to ex-situ locations. By bringing genomic technologies to Madagascar and other economically challenged and biodiverse regions of the world, the next generation of scientists and conservationists can more fully implement their leadership roles. Local laboratory and training facilities are changing the polarity of research programs in Madagascar and empowering national researchers to take charge of environmental stewardship.
Harnessing Mental Imagery and Enhancing Memory Specificity: Developing a Brief Early Intervention for Depressive Symptoms in Adolescence
Authors: Pile Victoria , Smith Patrick , Leamy Mary , Oliver Abigail , Blackwell Simon E. , Meiser-Stedman Richard , Dunn Barnaby D. , Holmes Emily A. , Lau Jennifer Y. F.
Published: August 2020

Background

Treatment innovation for depressive symptoms in adolescence is urgently needed. Adult research suggests interventions targeting underlying cognitive mechanisms, such as dysfunctional mental imagery and overgeneral memory, are promising. Here, we describe and evaluate in a case series a brief imagery-based intervention for depressive symptoms that targets these cognitive mechanisms.

Methods

Nine participants completed the four-session intervention, whose principle components were imagery rescripting and memory specificity training. Questionnaires and experimental tasks (assessing symptomatology and cognitive mechanisms) were administered at three time points: pre-intervention, post-intervention and 3-month follow-up.

Results

The intervention was feasible to deliver and acceptable to participants. There was a large reduction in depression symptom scores from pre to post intervention (d = 1.32; 67% showed reliable improvement, RI) and this was maintained at follow-up (d = 1.46; RI = 75%). There were also reductions in anxiety (post: d = 1.15, RI = 44%; follow-up: d = 1.67, RI = 63%), increases in self-esteem (post: d = − 0.70, RI = 44%; follow-up: d = − 1.20, RI = 50%) and noteworthy changes in memory specificity (post: d = − 1.80, RI = 67%; follow-up: d = − 0.94, RI = 63%).

Conclusions

This is the first study to use imagery rescripting and memory specificity training in adolescence. Initial evidence is provided that the intervention is acceptable and may have clinical utility. Future randomised controlled trials are needed to further assess the intervention.
Cats singing in the dark? Spawning aggregations of sound-producing fish in Amazonian floodplain forests
Authors: van der Sleen Peter , Lugo-Carvajal Arnold , Zuanon Jansen , Holmgren Milena
Published: August 2020

The Amazon basin has a freshwater fish diversity comparable to a tropical sea. Although many Amazonian fish species are popular ornamental fish across the world, the ecology of most species in their natural habitat remains poorly known (van der Sleen and Albert 2017). We report on shoaling behavior inPlatydoras hancockiiin a floodplain forest of the middle Rio Negro, Brazil. As the shoal consisted of only adult males, whereas gravid females were caught individually in nearby areas, we hypothesize that this aggregation may relate to spawning. Moreover, considering thatPlatydoras hancockiiis capable of producing sounds, it is possible that these aggregations entail the formation of a chorus-like call with the function of attracting females from a larger area.
An Extensional Mereology for Structured Entities
Authors: Canavotto Ilaria , Giordani Alessandro
Published: August 2020

In this paper, we present an extensional system of mereology suitable to account for the intuitive distinction between heaplike and non-heaplike entities. Since the need to capture this distinction has been a key motivation for non-extensional mereologies, we first assess the main non-extensional systems advanced in the last years and highlight some mereological and metaphysical difficulties they involve. We then advance a novel program, according to which the distinction between heaplike and non-heaplike entities can be accounted for by bringing together the parthood relation characterized by classical extensional mereology and an Aristotelian extensional notion of potential parthood. Thus, while rejecting the thesis of mereological monism, our proposal is consistent with the thesis of mereological extensionalism. We show that within this framework it is possible to characterize the above-mentioned distinction, to define the relation of material constitution, and to capture three fundamental standpoints in metaphysics.
Expanding the Romantic Circle
Authors: Thau Tena
Published: August 2020

Our romantic lives are influenced, to a large extent, by our perceptions of physical attractiveness – and the societal beauty standards that shape them. But what if we could free our desires from this fixation on looks? Science fiction writer Ted Chiang has explored this possibility in a fascinating short story – and scientific developments might, in the future, move it beyond the realm of fiction. In this paper, I lay out the prudential case for using “attraction-expanding technology,” and then consider it from a moral point of view. Using the technology would, in one respect, be morally good: it would benefit those whom prevailing beauty standards marginalize. But attraction-expanding technology also raises a moral concern – one that can be cast in non-harm-based and harm-based terms. I argue that the non-harm-based objection should be rejected, because it is incompatible with a moral principle central to queer rights. And the harm-based objection, I argue, is outweighed by the benefits of attraction-expanding technology, and undermined by the prerogative you have over your personal romantic choices. I conclude by considering whether, from the perspective of society, the development of attraction-expanding technology would be desirable.
TSCMF: Temporal and social collective matrix factorization model for recommender systems
Authors: Tahmasbi Hamidreza , Jalali Mehrdad , Shakeri Hassan
Published: August 2020

In real-world recommender systems, user preferences are dynamic and typically change over time. Capturing the temporal dynamics of user preferences is essential to design an efficient personalized recommender system and has recently attracted significant attention. In this paper, we consider user preferences change individually over time. Moreover, based on the intuition that social influence can affect the users’ preferences in a recommender system, we propose a Temporal and Social Collective Matrix Factorization model called TSCMF for recommendation. We jointly factorize the users’ rating information and social trust information in a collective matrix factorization framework by introducing a joint objective function. We model user dynamics into this framework by learning a transition matrix of user preferences between two successive time periods for each individual user. We present an efficient optimization algorithm based on stochastic gradient descent for solving the objective function. The experiments on a real-world dataset illustrate that the proposed model outperforms the competitive methods. Moreover, the complexity analysis demonstrates that the proposed model can be scaled up to large datasets.
Correlation of Acoustic Emission with Fractography in Bending of Glass–Epoxy Composites
Authors: Panek Maciej , Blazewicz Stanislaw , Konsztowicz Krzysztof J.
Published: August 2020

Damage processes in glass fiber reinforced plastic composites have been examined extensively by many analytical and experimental methods, including acoustic emission. While damage phenomena in mezo- and macro-scale are well described, the subtle mechanisms in micro-scale are still under discussion. The goal of this work was to apply the acoustic emission to examine damage initiation in fiber reinforced epoxy resin composites with different continuous glass-fiber architectures. Basic lay-ups were used: unidirectional, cross-ply and angle-ply, each with varying fiber volume content in epoxy matrix. Detection of fine micro-cracks was possible owing to merging the mechanical monotonic and step-load tests in 4-point bending with acoustic emission monitoring and detailed scanning electron microscopy observations. Clear images of macroscopically undamaged samples after interruption of step-loading cycles revealed the initiation of micro-cracks by debonding of fiber-matrix interfaces, in agreement with acoustic emission signal analyses, featuring use of historic index and rise time/amplitude ratio.
The foundations of the “public organisation”: governance failure and the problem of external effects
Authors: Sacchetti Silvia , Borzaga Carlo
Published: August 2020

The article constructs a model of firm governance that considers the wider effects of economic activity, thus bridging the organisational level and the macro level. The theoretical framework builds on Hansmann’s ownership model and introduces an alternative. The “total cost model” advanced directs attention to concerns that are not entirely addressed by standard transaction cost theory and suggests that, when the external costs are high, a firm may need to extend the governance function to multiple patrons and absorb some external costs in pursuit of multiple public goals. Who should be included in the strategic control function will depend on the anticipated effects in terms of the external costs and the costs of organising. The article argues that this set-up helps to explain the “public organisation”, defined as a private organisation with public interest objectives, and further claims that this model helps to justify the recent emergence of multi-stakeholder social enterprises.
Vision-based human activity recognition: a survey
Authors: Beddiar Djamila Romaissa , Nini Brahim , Sabokrou Mohammad , Hadid Abdenour
Published: August 2020

Human activity recognition (HAR) systems attempt to automatically identify and analyze human activities using acquired information from various types of sensors. Although several extensive review papers have already been published in the general HAR topics, the growing technologies in the field as well as the multi-disciplinary nature of HAR prompt the need for constant updates in the field. In this respect, this paper attempts to review and summarize the progress of HAR systems from the computer vision perspective. Indeed, most computer vision applications such as human computer interaction, virtual reality, security, video surveillance and home monitoring are highly correlated to HAR tasks. This establishes new trend and milestone in the development cycle of HAR systems. Therefore, the current survey aims to provide the reader with an up to date analysis of vision-based HAR related literature and recent progress in the field. At the same time, it will highlight the main challenges and future directions.
Emotional quantification of soundscapes by learning between samples
Authors: Ntalampiras Stavros
Published: August 2020

Predicting the emotional responses of humans to soundscapes is a relatively recent field of research coming with a wide range of promising applications. This work presents the design of two convolutional neural networks, namely ArNet and ValNet, each one responsible for quantifying arousal and valence evoked by soundscapes. We build on the knowledge acquired from the application of traditional machine learning techniques on the specific domain, and design a suitable deep learning framework. Moreover, we propose the usage of artificially created mixed soundscapes, the distributions of which are located between the ones of the available samples, a process that increases the variance of the dataset leading to significantly better performance. The reported results outperform the state of the art on a soundscape dataset following Schafer’s standardized categorization considering both sound’s identity and the respective listening context.
Managing medicines in the time of COVID-19: implications for community-dwelling people with dementia
Authors: Barry Heather E. , Hughes Carmel M.
Published: August 2020

COVID-19 has changed life beyond recognition for millions of individuals, as countries implement social distancing measures to prevent disease transmission. For certain patient groups, such as community-dwelling older people with dementia (PwD), these restrictions may have far-reaching consequences. Medicines management may be adversely affected and deserves careful thought. PwD face unique challenges with medicines management compared to other older people, often relying upon support from family/carers and primary healthcare professionals. This article considers potential issues that PwD may face with each component of medicines management (prescribing, dispensing, administration, adherence, review), and based on previous research, highlights strategies to support PwD and their carers during this time. Primary healthcare professionals must be attentive to medicines-related needs of community-dwelling PwD, particularly those living alone, both during the pandemic and as restrictions are lifted. Carers of PwD continue to have a critical role to play in medicines management, and also require support.
Auraptene and umbelliprenin: a review on their latest literature acquisitions
Authors: Fiorito Serena , Preziuso Francesca , Sharifi-Rad Majid , Marchetti Lorenzo , Epifano Francesco , Genovese Salvatore
Published: August 2020

Auraptene and umbelliprenin are among the most abundant naturally occurring prenyloxy umbelliferone derivatives. Both have been mainly isolated from plants belonging to numerous genera of the Rutaceae (in particular auraptene in Citrus spp.) and Apiaceae (in particular umbelliprenin in Ferula spp.) families, comprising different and widely used medicinal plants and in general plants having beneficial effects to human welfare as well as edible fruits and vegetables. Although known for quite a long time (nearly a century for auraptene and 50 years for umbelliprenin), only in the last two decades the two title natural compounds were revealed to possess valuable and promising pharmacological properties as dietary feeding active cancer chemopreventive, anti-bacterial, anti-protozoal, anti-fungal, anti-inflammatory, neuroprotective, and anti-oxidant agents among the activities best detailed in the recent literature. The aim of this comprehensive review is to outline in detail the effects described in the very last years for auraptene and umbelliprenin and what has been reported about the mechanisms of action underlying the observed pharmacological activities of these oxyprenylated secondary metabolites. In view of the herein described data suggestions on how to address the future research about both natural products in the best ways according to Authors will be also provided.
Assessing the impacts of having a child with achondroplasia on parent well-being
Authors: Pfeiffer Kathryn M. , Brod Meryl , Smith Alden , Gianettoni Jill , Viuff Dorthe , Ota Sho , Charlton R. Will
Published: August 2020

Purpose

This study’s purpose was to develop a better understanding of the experiences of parents of children with achondroplasia and to provide qualitative evidence to support the development of a patient-reported outcome (PRO) measure of parent impacts.

Methods

Concept elicitation (CE) individual/focus group interviews were conducted with parents of children aged 2 to < 12 years with achondroplasia in the United States and Spain. The qualitative analysis informed the PRO measure development. Cognitive debriefing (CD) interviews were conducted to ensure parent understanding and item relevance.

Results

Thirty-six parents participated in individual/focus group CE interviews. The analysis identified parent impacts in four domains, including caretaking responsibilities, emotional well-being, family, and work, and results informed the development of the Achondroplasia Parent Experience Measure (APEM). Caretaking responsibilities included managing child’s medical care (92%), helping child with self-care (67%), advocating for child (64%), assisting child (56%), and observing/monitoring child (e.g., to ensure safety; 47%). Impacts on parents’ emotional well-being included worry about the future (75%), worry about child’s physical health (67%), safety concerns (50%), feeling stressed/overwhelmed (44%), and worry about child’s social relationships (42%). Impacts on family and work included family strain (56%), limiting/adapting family activities (42%), and missed work time (50%). CD interviews with an additional 16 parents of children with achondroplasia confirmed understanding and item relevance.

Conclusion

The results improve our understanding of the experiences of parents of children with achondroplasia and provide qualitative evidence to support the content validity of the APEM. A psychometric study is needed to validate the measure.
Droplet-vitrification cryopreservation of Tulipa tarda Stapf. apical meristems
Authors: Maślanka¹ Małgorzata , Szewczyk² Agnieszka
Published: August 2020

The present study provides an efficient cryopreservation protocol for Tulipa tarda cultured in vitro. Apices were excised from bulblets cultivated on MS medium, supplemented with 60 or 90 g l− 1 sucrose. Half of the bulblets were subjected to a cold treatment at 5 °C for 10 weeks, before exposure of the apices to loading solution (LS) and plant vitrification solution 2 (PVS2). Ten weeks after rewarming and culture on recovery medium, 100% regrowth rates were obtained for cold treated explants cultured on 60 g l− 1 sucrose after 30 and 60 min exposure to PVS2. Cold treatment significantly improved the recovery rates of most of the cryopreserved apical meristems while an enrichment of the culture medium with higher sucrose concentration (90 g l− 1) did not improve regrowth of the apices.
Juvenile primary Sjögren’s syndrome with ranula: is ranula a clinical sign that leads to early detection of Sjögren’s syndrome?
Authors: Takagi Yukinori , Hashimoto Kunio , Katayama Ikuo , Eida Sato , Sumi Misa
Published: August 2020

Juvenile primary Sjögren’s syndrome (pSS) is rare. Although recurrent parotitis is reported to be the most common symptom of juvenile pSS, the clinical symptoms and features of the syndrome are not well understood and are poorly defined. Here we report a rare case of juvenile pSS in a patient with plunging ranula. The patient had no symptoms other than swelling of the oral floor and had no symptoms of parotitis. Magnetic resonance imaging (MRI) revealed the diagnosis of plunging ranula. In addition, the findings of the bilateral parotid glands on MRI and subsequent ultrasonography (US) strongly suggested SS. On the basis of these imaging findings and laboratory data, a pediatric rheumatologist confirmed the diagnosis of juvenile pSS. The ranula may be one clinical sign of SS. However, this association remains generally unknown. Hypothesizing that SS might cause ranula development, we retrospectively investigated cases of patients with ranula who underwent MRI at our hospital. We found that many of these patients (> 20%) had characteristic findings strongly suggestive of SS. This result suggests that SS-induced changes in the sublingual glands are one cause of ranula formation. We think that ranula is a sign of early-stage SS. Therefore, patients with ranulae, whether adults or children, should undergo careful assessment of not only the sublingual glands but also the parotid and submandibular glands with MRI and/or US to investigate possible SS. This assessment may lead to early detection of SS.
Rational Behavior of Dictators - Evidence on Gender and Religiosity
Authors: Staniszewska Aleksandra , Czerwonka Monika , Kompa Krzysztof
Published: August 2020

The dictator game (DG) is one of the simplest and most commonly used experimental games for examining economic and altruistic behaviors. Altruism became crucial in research on decisions in experimental and behavioral economy. This study extends existing research on the relationship between cognitive performance, measured by the Cognitive Reflection Test (CRT) and the DG, taking into account such factors as gender and declared religiosity. The research assesses whether gender and declared religiosity affect altruistic behavior measured in the DG’s payoffs. 511 participants (master’s students in economics) were asked to respond to six types of DGs and the CRT7 test. Correlation analysis, descriptive statistics, student t-tests, the Mann-Whitney test and Tobit regression analysis were conducted. Cognitive reflection was positively correlated with rational (selfish) behavior in the DG. Those dictators who scored high on the CRT (reflective dictators) kept more money for themselves than those who achieved lower scores on the CRT (altruistic, impulsive dictators). The results confirmed a distinct, inequity aversion attitude among altruistic, impulsive dictators and a selfish attitude among reflective dictators. The dictator’s payoff was significantly related to the gender and declared religiosity of the participants. Women were more concerned about equal distribution of income than men (on average they shared 30% more than men) and religious agents shared 20%–30% more than non-believers.
Factor Uniqueness of the Structural Parafac Model
Authors: Giordani Paolo , Rocci Roberto , Bove Giuseppe
Published: August 2020

Factor analysis is a well-known method for describing the covariance structure among a set of manifest variables through a limited number of unobserved factors. When the observed variables are collected at various occasions on the same statistical units, the data have a three-way structure and standard factor analysis may fail. To overcome these limitations, three-way models, such as the Parafac model, can be adopted. It is often seen as an extension of principal component analysis able to discover unique latent components. The structural version, i.e., as a reparameterization of the covariance matrix, has been also formulated but rarely investigated. In this article, such a formulation is studied by discussing under what conditions factor uniqueness is preserved. It is shown that, under mild conditions, such a property holds even if the specific factors are assumed to be within-variable, or within-occasion, correlated and the model is modified to become scale invariant.
White rot fungi can be a promising tool for removal of bisphenol A, bisphenol S, and nonylphenol from wastewater
Authors: Grelska Agnieszka , Noszczyńska Magdalena
Published: August 2020

Endocrine-disrupting chemicals (EDC) are a wide group of chemicals that interfere with the endocrine system. Their similarity to natural steroid hormones makes them able to attach to hormone receptors, thereby causing unfavorable health effects. Among EDC, bisphenol A (BPA), bisphenol S (BPS), and nonylphenol (NP) seem to be particularly harmful. As the industry is experiencing rapid expansion, BPA, BPS, and NP are being produced in growing amounts, generating considerable environmental pollution. White rot fungi (WRF) are an economical, ecologically friendly, and socially acceptable way to remove EDC contamination from ecosystems. WRF secrete extracellular ligninolytic enzymes such as laccase, manganese peroxidase, lignin peroxidase, and versatile peroxidase, involved in lignin deterioration. Owing to the broad substrate specificity of these enzymes, they are able to remove numerous xenobiotics, including EDC. Therefore, WRF seem to be a promising tool in the abovementioned EDC elimination during wastewater treatment processes. Here, we review WRF application for this EDC removal from wastewater and indicate several strengths and limitations of such methods.