bluuebunny/crossref_metadata_2025 huggingface dataset:
Biomineralization Forming Process and Bio-inspired Nanomaterials for Biomedical Application: A Review
Authors: Chen Yuanyuan , Feng Yanmin , Deveaux John Gregory , Masoud Mohamed Ahmed , Chandra Felix Sunata , Chen Huawei , Zhang Deyuan , Feng Lin
Published: January 2019

Biomineralization is a process in which organic matter and inorganic matter combine with each other under the regulation of living organisms. Because of the biomineralization-induced super survivability and retentivity, biomineralization has attracted special attention from biologists, archaeologists, chemists, and materials scientists for its tracer and transformation effect in rock evolution study and nanomaterials synthesis. However, controlling the biomineralization process in vitro as precisely as intricate biology systems still remains a challenge. In this review, the regulating roles of temperature, pH, and organics in biominerals forming process were reviewed. The artificially introducing and utilization of biomineralization, the bio-inspired synthesis of nanomaterials, in biomedical fields was further discussed, mainly in five potential fields: drug and cell-therapy engineering, cancer/tumor target engineering, bone tissue engineering, and other advanced biomedical engineering. This review might help other interdisciplinary researchers to bionic-manufacture biominerals in molecular-level for developing more applications of biomineralization.
QuEChERS and HPLC-MS/MS Combination for the Determination of Chloramphenicol in Twenty Two Different Matrices
Authors: Śniegocki Tomasz , Sell Bartosz , Giergiel Marta , Posyniak Andrzej
Published: January 2019

A simple method for the determination of chloramphenicol in 22 matrices was prepared based on the QuEChERS and HPLC-MS/MS combination. Following a hydrolysis step, the homogenized samples were extracted and partitioned after adding sodium chloride with acetonitrile. Chloramphenicol was analysed by HPLC-MS/MS in negative electrospray mode by monitoring the daughter ions m/z: 321→194 and 321→152. The limit of decision (CCα) was calculated at the range of 0.10 μg kg−1 to 0.15 μg kg−1 and detection capability (CCβ) from 0.12 μg kg−1 to 0.18 μg kg−1. Validation results showed that this method is suitable for the determination and confirmation of chloramphenicol in various matrices.
Structural and Rheological Properties of Pectins Extracted from Industrial Sugar Beet By-Products
Authors: Pacheco M. Teresa , Villamiel Mar , Moreno Rodrigo , Moreno F. Javier
Published: January 2019

In this work, the efficient extraction of pectin from sugar beet by-products (pressed, ensiled and dried pulp), by using an acid method or a commercial cellulose, is accomplished. The extraction method had an impact on the pectin monomeric composition, mainly in xylose, arabinose, and galacturonic acid content, as determined by GC-FID. FTIR and SEC analyses allowed the determination of similar degrees of methoxylation and molecular weights, respectively, in the extracted pectins. The acid extraction of pectin in the ensiled by-product led to the highest yield (19%) with a galacturonic acid content of 46%, whereas the application of the enzymatic extraction method resulted in a lower yield (13%) but higher galacturonic acid content (72%). Moreover, the stability in aqueous solution as well as the emulsifying activity index was higher for pectin extracted by the acid method, whereas the viscosity was higher in pectin extracted by the enzymatic method. To the best of our knowledge, this is the first study analyzing the physicochemical properties and exploring the potential reuse of ensiled and dried by-products from sugar beet industry for the extraction of pectin to be further used in the food and pharmaceutical areas.
Isatin-1,8-Naphthalimide Hydrazones: A Study of Their Sensor and ON/OFF Functionality
Authors: Tisovský Pavol , Horváth Miroslav , Csicsai Klaudia , Donovalová Jana , Filo Juraj , Cigáň Marek , Sokolík Róbert , Addová Gabriela , Gáplovský Anton
Published: January 2019

Five novel hydrazones derived from substituted isatins were synthesized as potential anion sensors. Using UV-VIS, FTIR, NMR and fluorescence spectroscopy, these compounds’ tautomeric equilibrium and Z-E photoisomerization were studied in DMF and CHCl3, depending on the hydrazone concentrations, the presence of basic anions and light stimulation. Anion recognition aspects (PF6−, HSO4−, Br−, Cl−, NO3−, F− and CH3COO−) and these receptors’ detection limits were also studied. We also tested the light-stimulated ON-OFF functionality of these compounds in the presence or absence of these anions.
Medium Chain Carboxylic Acids from Complex Organic Feedstocks by Mixed Culture Fermentation
Authors: De Groof Vicky , Coma Marta , Arnot Tom , Leak David J , Lanham Ana B
Published: January 2019

Environmental pressures caused by population growth and consumerism require the development of resource recovery from waste, hence a circular economy approach. The production of chemicals and fuels from organic waste using mixed microbial cultures (MMC) has become promising. MMC use the synergy of bio-catalytic activities from different microorganisms to transform complex organic feedstock, such as by-products from food production and food waste. In the absence of oxygen, the feedstock can be converted into biogas through the established anaerobic digestion (AD) approach. The potential of MMC has shifted to production of intermediate AD compounds as precursors for renewable chemicals. A particular set of anaerobic pathways in MMC fermentation, known as chain elongation, can occur under specific conditions producing medium chain carboxylic acids (MCCAs) with higher value than biogas and broader applicability. This review introduces the chain elongation pathway and other bio-reactions occurring during MMC fermentation. We present an overview of the complex feedstocks used, and pinpoint the main operational parameters for MCCAs production such as temperature, pH, loading rates, inoculum, head space composition, and reactor design. The review evaluates the key findings of MCCA production using MMC, and concludes by identifying critical research targets to drive forward this promising technology as a valorisation method for complex organic waste.
Three-Phase Partitioning for the Extraction and Purification of Polysaccharides from the Immunomodulatory Medicinal Mushroom Inonotus obliquus
Authors: Liu Zhendong , Yu Dongsheng , Li Liang , Liu Xiaoxiao , Zhang Henan , Sun Wenbo , Lin Chi-Chung , Chen Jiafu , Chen Zhi , Wang Wenhan , Jia Wei
Published: January 2019

Polysaccharides from the immunomodulatory medicinal mushroom Inonotus obliquus (IOPS) were extracted and purified using three-phase partitioning (TPP), which is an efficient, fast, safe, and green purification technique. An optimal extraction procedure that gave a good 2.2% isolated yield was identified, using the following protocol: a solid-liquid ratio of 1 g to 12 mL; mass fraction of (NH4)2SO4 20% (w/v); 11 mL t-butanol; pH 8.0; temperature 30 °C; and extraction time 30 min. The purified IOPS was shown to be a proteoglycan of 40 kDa molecular weight comprising of d-galactose, d-glucose, d-xylose, and d-mannose in a molar ratio of 2.0:3.5:1.0:1.5. The purified IOPS displayed strong free-radical scavenging abilities, antioxidant activities, and immunological activity in vitro. IOPS’ Trolox antioxidant equivalent capacity and ferric-reducing ability of plasma were 251.2 μmol Trolox/g sample and 1040.5 μmol Fe2+/g sample, respectively, with the activity of its immunomodulatory behavior shown to be gradient dependent.
Protein–Phenolic Interactions as a Factor Affecting the Physicochemical Properties of White Bean Proteins
Authors: Sęczyk Łukasz , Świeca Michał , Kapusta Ireneusz , Gawlik-Dziki Urszula
Published: January 2019

This study was conducted with an aim to determine the interactions of pure phenolic compounds (gallic acid, ferulic acid, chlorogenic acid, quercetin, apigenin, and catechin) and phenolics from plant extracts (green tea and green coffee) with protein fractions of white bean (albumins and globulins). The physicochemical properties of complexes were established through an analysis of the UV-Vis spectrum; relative content of free amino groups, thiol groups, and tryptophan residues; chromatographic (SE-HPLC) and electrophoretic (SD-PAGE, Native-PAGE) properties; and conformational changes reflected by Fourier transform infrared spectra. Further, the effect of pH and ionic strength on the solubility and stability of complexes as well as the binding capacity of phenolics to proteins were determined. Results show that, in most cases, phenolics significantly affected the measured parameters; however, the effects were strongly differentiated by the type of phenolic compounds and protein fraction that were applied. Moreover, it may be that changes in the properties of complexes are reflected in the biological nature of proteins and phenolic compounds such as their bioavailability and physiological activity. However, due to the structural complexity of proteins, and the multitudinous factors that affect their interactions, such studies are a great and long-term challenge for the domain of food science.
Discovery of a New Xanthone against Glioma: Synthesis and Development of (Pro)liposome Formulations
Authors: Alves Ana , Correia-da-Silva Marta , Nunes Claúdia , Campos João , Sousa Emília , Silva Patrícia M.A. , Bousbaa Hassan , Rodrigues Francisca , Ferreira Domingos , Costa Paulo C. , Pinto Madalena
Published: January 2019

Following our previous work on the antitumor activity of acetylated flavonosides, a new acetylated xanthonoside, 3,6-bis(2,3,4,6-tetra-O-acetyl-β-glucopyranosyl)xanthone (2), was synthesized and discovered as a potent inhibitor of tumor cell growth. The synthesis involved the glycosylation of 3,6-di-hydroxyxanthone (1) with acetobromo-α-d-glucose. Glycosylation with silver carbonate decreased the amount of glucose donor needed, comparative to the biphasic glycosylation. Xanthone 2 showed a potent anti-growth activity, with GI50 < 1 μM, in human cell lines of breast, lung, and glioblastoma cancers. Current treatment for invasive brain glioma is still inadequate and new agents against glioblastoma with high brain permeability are urgently needed. To overcome these issues, xanthone 2 was encapsulated in a liposome. To increase the well-known low stability of these drug carriers, a proliposome formulation was developed using the spray drying method. Both formulations were characterized and compared regarding three months stability and in vitro anti-growth activity. While the proliposome formulation showed significantly higher stability, it was at the expense of losing its biocompatibility as a drug carrier in higher concentrations. More importantly, the new xanthone 2 was still able to inhibit the growth of glioblastoma cells after liposome formulation.
Mechanisms of Methylparaben Adsorption onto Activated Carbons: Removal Tests Supported by a Calorimetric Study of the Adsorbent–Adsorbate Interactions
Authors: Bernal Valentina , Giraldo Liliana , Moreno-Piraján Juan Carlos , Balsamo Marco , Erto Alessandro
Published: January 2019

In this study, the mechanisms of methylparaben adsorption onto activated carbon (AC) are elucidated starting from equilibrium and thermodynamic data. Adsorption tests are carried out on three ACs with different surface chemistry, in different pH and ionic strength aqueous solutions. Experimental results show that the methylparaben adsorption capacity is slightly affected by pH changes, while it is significantly reduced in the presence of high ionic strength. In particular, methylparaben adsorption is directly dependent on the micropore volume of the ACs and the π- stacking interactions, the latter representing the main interaction mechanism of methylparaben adsorption from liquid phase. The equilibrium adsorption data are complemented with novel calorimetric data that allow calculation of the enthalpy change associated with the interactions between solvent-adsorbent, adsorbent-adsorbate and the contribution of the ester functional group (in the methylparaben structure) to the adsorbate–adsorbent interactions, in different pH and ionic strength conditions. It was determined that the interaction enthalpy of methylparaben-AC in water increases (absolute value) slightly with the basicity of the activated carbons, due to the formation of interactions with π- electrons and basic functional groups of ACs. The contribution of the ester group to the adsorbate-adsorbent interactions occurs only in the presence of phenol groups on AC by the formation of Brønsted–Lowry acid–base interactions.
Copolymers and Hybrids Based on Carbazole Derivatives and Their Nanomorphology Investigation
Authors: Aivali Stefania , Kakogianni Sofia , Anastasopoulos Charalampos , Andreopoulou Aikaterini K. , Kallitsis Joannis K.
Published: January 2019

Oligomers of the low-band-gap PCDTBT polymer, based on either 3,6 or 2,7 carbazole units, were modified with vinyl ω-chain end functionalities. The vinyl-functionalized oligomers were used as comonomers in free radical polymerizations with quinoline-based monomers such as 6-vinylphenyl-(2-pyridinyl)-4-phenyl-quinoline (vinyl-QPy), and 6-vinylphenyl-(2-perfluorophenyl)-4-phenyl quinoline (vinyl-5FQ). The co-polymeric materials bearing the vinyl-QPy moiety were developed as potential compatibilizers in polymer electron donor–fullerene acceptor blends for non-covalent interactions with the fullerene part. The co-polymeric materials bearing the vinyl-5FQ moiety were developed for the covalent attachment of carbon nanostructures; specifically, PC61BM. Both copolymers and hybrids, after thorough purification, were characterized in terms of their spectroscopic and optical properties as well as their ability to form nanophased separated films as such, or as additives at various percentages into PCDTBT: PC71BM blends.
Growth Kinetics of the Selected Intermetallic Phases in Ni/Al/Ni System with Various Nickel Substrate Microstructure
Authors: Kwiecien Izabella , Bobrowski Piotr , Wierzbicka-Miernik Anna , Litynska-Dobrzynska Lidia , Wojewoda-Budka Joanna
Published: January 2019

Reactivity in nickel–aluminum system was examined for two variants of nickel substrates in terms of the size and shape of Ni grains. The microstructure transformation aroused due to the annealing at 720 °C for different annealing times (0.25 to 72 h) was consequently followed. The sequence of formation of the particular intermetallic phases was given. The interconnection zones were examined by means of scanning electron microscopy supported with energy dispersive X-ray spectroscopy and electron backscattered diffraction techniques as well as by the transmission electron microscopy. The growth kinetics data for AlNi, AlNiNi-rich and AlNi3 phases for both variants of substrates was given, indicating the differences obtained in previous works on this subject.
Excellent Microwave Absorption Properties Derived from the Synthesis of Hollow Fe3o4@Reduced Graphite Oxide (RGO) Nanocomposites
Authors: Cui Guangzhen , Lu Yanli , Zhou Wei , Lv Xuliang , Hu Jiangnan , Zhang Guoyu , Gu Guangxin
Published: January 2019

Magnetic nanoparticles, such as Fe3O4 and Co3O4, play a vital role in the research on advanced microwave absorbing materials, even if problems such as high density and narrow band impedance matching are still unsolved. Herein, the study of lightweight hollow Fe3O4@reduced graphite oxide (RGO) nanocomposites synthesized via the solvothermal method is presented. The microstructure and crystal morphology of the materials were characterized by X-ray diffractometer (XRD), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), and transmission electron microscopy (TEM) analyses. Single crystalline hollow Fe3O4 spheres were grown onto RGO flakes, leading to the formation of heterojunction, which further influenced the microwave absorption properties. The latter were evaluated by standard microwave characterization in the frequency range of 2–18 GHz. It was found that, for a specific Fe3O4@0.125 g RGO composite, the minimum reflection loss can reach −41.89 dB at 6.7 GHz, while the reflection loss was less than −10 dB from 3.4 GHz to 13.6 GHz for a nanocomposite sample thickness in the range of 1–4 mm. The combination of these two materials thus proved to give remarkable microwave absorption properties, owing to enhanced magnetic losses and favorable impedance matching conditions.
Cytoprotective Effects of Mangiferin and Z-Ligustilide in PAH-Exposed Human Airway Epithelium in Vitro
Authors: Grauzdytė Dovilė , Raudoniūtė Jovilė , Kulvinskienė Ieva , Bagdonas Edvardas , Stasiulaitienė Inga , Martuzevičius Dainius , Bironaitė Daiva , Aldonytė Rūta , Venskutonis Petras Rimantas
Published: January 2019

According to World Health Organisation (WHO) air pollution increases the risk of cardiovascular disorders, respiratory diseases, including COPD, lung cancer and acute respiratory infections, neuro-degenerative and other diseases. It is also known that various phytochemicals may mitigate such risks. This study tested if phytochemicals mangiferin (MNG) and Z-ligustilide (Z-LG) may protect PAH-exposed human lung bronchial epithelial cells (BEAS-2B). Organic PAH extract was obtained from the urban fine PM with high benzo(a)pyrene content collected in Eastern European mid-sized city during winter heating season. Cell proliferation traits and levels of intracellular oxidative stress were examined. Effect of MNG (0.5 µg/mL) alone or in combination with PAH on bronchial epithelium wound healing was evaluated. Both phytochemicals were also evaluated for their antioxidant properties in acellular system. Treatment with MNG produced strong cytoprotective effect on PAH-exposed cells (p < 0.01) while Z-LG (0.5 µg/mL) exhibited strong negative effect on cell proliferation in untreated and PAH-exposed cells (p < 0.001). MNG, being many times stronger antioxidant than Z-LG in chemical in vitro assays (p < 0.0001), was also able to decrease PAH-induced oxidative stress in the cell cultures (p < 0.05). Consequently MNG ameliorates oxidative stress, speeds up wound healing process and restores proliferation rate in PAH-exposed bronchial epithelium. Such protective effects of MNG in air pollution affected airway epithelium stimulate further research on this promising phytochemical.
Exposure to a Farm Environment during Pregnancy Increases the Proportion of Arachidonic Acid in the Cord Sera of Offspring
Authors: Barman Malin , Jonsson Karin , Wold Agnes E. , Sandberg Ann-Sofie
Published: January 2019

Growing up in a farm environment is protective against allergy development. Various explanations have been put forward to explain this association. Fatty acids are regulators of immune function and the composition of fatty acids in the circulation system may affect immune development. Here, we investigate whether the fatty acid composition of cord serum differs for infants born to Farm (n = 26) or non-Farm mothers (n = 29) in the FARMFLORA birth-cohort. For comparison, the levels of fatty acids in the maternal diet, serum and breast milk around 1 month post-partum were recorded. The fatty acids in the cord sera from infants born to Farm mothers had higher proportions of arachidonic acid (20:4 n-6) and adrenic acid (22:4 n-6) than those from infants born to non-Farm mothers. No differences were found for either arachidonic acid or adrenic acid in the diet, samples of the serum, or breast milk from Farm and non-Farm mothers obtained around 1 month post-partum. The arachidonic and adrenic acid levels in the cord blood were unrelated to allergy outcome for the infants. The results suggest that a farm environment may be associated with the fatty acid composition to which the fetus is exposed during pregnancy.
Socioeconomic Disadvantage across the Life Course Is Associated with Diet Quality in Young Adulthood
Authors: Faught Erin L. , McLaren Lindsay , Kirkpatrick Sharon I. , Hammond David , Minaker Leia M. , Raine Kim D. , Olstad Dana Lee
Published: January 2019

Socioeconomic position (SEP) is a key determinant of diet quality across the life course. Young adulthood is a unique period of transition where dietary inequities between groups with lower and higher SEP may widen. This study investigated associations between SEP in both childhood and young adulthood and diet quality in young adulthood. Data from 1949 Canadian young adults aged 18–30 who participated in the Canada Food Study were analyzed. Healthy Eating Index–2015 (HEI-2015) scores were calculated based on one 24-hour dietary recall. Childhood and young adult SEP were represented by self-report of participants’ parent(s)’ and their own highest educational level, respectively. Linear regression was used to examine associations between childhood and adult SEP and adult HEI-2015 score. Mediation analyses examined whether adult SEP mediated the relationship between childhood SEP and adult HEI-2015 score. Lower SEPs in childhood and adulthood were each associated with lower HEI-2015 scores in young adulthood. Adult SEP mediated up to 13.0% of the association between childhood SEP and adult HEI-2015 scores. Study findings provide support for key life course hypotheses and suggest latent, pathway, and cumulative effects of SEP across the early life course in shaping the socioeconomic patterning of diet quality in young adulthood.
Biotechnological Approaches for Generating Zinc-Enriched Crops to Combat Malnutrition
Authors: Hefferon Kathleen
Published: January 2019

The past twenty years have seen the application of biotechnology to generate nutritionally improved food crops. Biofortified rice, cassava, maize, sorghum and other staple crops biofortified with essential micronutrients have great potential to benefit the world’s poor, in terms of both health and economics. This paper describes the use of genetic modification to generate crops that are biofortified with zinc. Examples of zinc-enhanced crops which have been developed using biotechnological approaches will be discussed, and new approaches for research and development will be outlined. The impact of these biofortified crops on human health and well-being will be examined. This paper will conclude with a discussion of the obstacles that must be overcome to enable zinc-fortified crops to be accessible for the world’s malnourished.
Daily Green Tea Infusions in Hypercalciuric Renal Stone Patients: No Evidence for Increased Stone Risk Factors or Oxalate-Dependent Stones
Authors: Rode Julie , Bazin Dominique , Dessombz Arnaud , Benzerara Yahia , Letavernier Emmanuel , Tabibzadeh Nahid , Hoznek Andras , Tligui Mohamed , Traxer Olivier , Daudon Michel , Haymann Jean-Philippe
Published: January 2019

Green tea is widely used as a ‘’healthy’’ beverage due to its high level of antioxidant polyphenol compounds. However tea is also known to contain significant amount of oxalate. The objective was to determine, in a cross-sectional observational study among a population of 273 hypercalciuric stone-formers referred to our center for metabolic evaluation, whether daily green tea drinkers (n = 41) experienced increased stone risk factors (especially for oxalate) compared to non-drinkers. Stone risk factors and stone composition were analyzed according to green tea status and sex. In 24-h urine collection, the comparison between green tea drinkers and non-drinkers showed no difference for stone risk factors such as urine oxalate, calcium, urate, citrate, and pH. In females, the prevalence of calcium oxalate dihydrate (COD) and calcium phosphate stones, assessed by infrared analysis (IRS) was similar between green tea drinkers and non-drinkers, whereas prevalence of calcium oxalate monohydrate (COM) stones was strikingly decreased in green tea drinkers (0% vs. 42%, p = 0.04), with data in accordance with a decreased oxalate supersaturation index. In males, stone composition and supersaturation indexes were similar between the two groups. Our data show no evidence for increased stone risk factors or oxalate-dependent stones in daily green tea drinkers.
Probiotics: How Effective Are They in the Fight against Obesity?
Authors: Mazloom Kiran , Siddiqi Imran , Covasa Mihai
Published: January 2019

Obesity has been associated with structural and functional changes in the gut microbiota. The abundance in, and diversity of, certain bacteria may favor energy harvest and metabolic pathways leading to obesity. Therefore, gut microbiota has become a potential target that can be manipulated to obtain optimal health. Probiotics have been shown to influence the composition of the gut microbiota, improve gut integrity, and restore the microbial shifts characteristic of obesity. Based on physical and biochemical parameters, metabolic and inflammatory markers, and alterations in gut microbe diversity, animal studies revealed beneficial results in obese models whereas the results in humans are sparse and inconsistent. Thus, the purpose of this review is to present evidence from animal studies and human clinical trials demonstrating the effects of various probiotic strains and their potential efficacy in improving obesity and associated metabolic dysfunctions. Furthermore, the review discusses current gaps in our understanding of how probiotics modulate gut microflora to protect against obesity. Finally, we propose future studies and methodological approaches that may shed light on the challenges facing the scientific community in deciphering the host–bacteria interaction in obesity.
TRPV1 Inhibits the Ventilatory Response to Hypoxia in Adult Rats, but Not the CO2-Drive to Breathe
Authors: Patrone Luis , Duarte Jaime , Bícego Kênia , Steiner Alexandre , Romanovsky Andrej , Gargaglioni Luciane
Published: January 2019

Receptors of the transient receptor potential (TRP) channels superfamily are expressed in many tissues and have different physiological functions. However, there are few studies investigating the role of these channels in cardiorespiratory control in mammals. We assessed the role of central and peripheral TRPV1 receptors in the cardiorespiratory responses to hypoxia (10% O2) and hypercapnia (7% CO2) by measuring pulmonary ventilation ( V ˙ E ), heart rate (HR), mean arterial pressure (MAP) and body temperature (Tb) of male Wistar rats before and after intraperitoneal (AMG9810 [2.85 µg/kg, 1 mL/kg]) or intracebroventricular (AMG9810 [2.85 µg/kg, 1 µL] or AMG7905 [28.5 μg/kg, 1 µL]) injections of TRPV1 antagonists. Central or peripheral injection of TRPV1 antagonists did not change cardiorespiratory parameters or Tb during room air and hypercapnic conditions. However, the hypoxic ventilatory response was exaggerated by both central and peripheral injection of AMG9810. In addition, the peripheral antagonist blunted the drop in Tb induced by hypoxia. Therefore, the current data provide evidence that TRPV1 channels exert an inhibitory modulation on the hypoxic drive to breathe and stimulate the Tb reduction during hypoxia.
Pharmacodynamics and Pharmacokinetics of a New Type of Compound Lansoprazole Capsule in Gastric Ulcer Rats and Beagle Dogs: Importance of Adjusting Oxidative Stress and Inflammation
Authors: Wei Binbin , Wang Yan , Wu Huizhe , Liu Mingyan , Yao Weifan , Wei Minjie
Published: January 2019

The aim of this study was to investigate the pharmacodynamics and pharmacokinetics of a new type of compound lansoprazole capsule in gastric ulcer rats and beagle dogs in order to confirm whether it is more effective in treating gastric ulcers and its rapid absorption. A rat model of gastric ulcers was used to evaluate the anti-ulcerogenic effect of the compound lansoprazole capsule. A fast and sensitive UPLC-MS/MS method was developed to detect lansoprazole in dog plasma. Macroscopic and histological evaluation results revealed that the compound lansoprazole capsule is more effective in treating gastric ulcers as it was able to significantly reduce the gastric ulcer compared to the other groups. Additionally, it was able to enhance the expression of the antioxidant enzyme superoxide dismutase (SOD) and suppress lipid peroxidation as indicated by the reduction of malondialdehyde (MDA) and H+-K+-ATP activity. Furthermore, this capsule increased the expression of mucosal vascular endothelial growth factor (VEGF) and cyclic oxygenase 2 (COX-2). The established UPLC-MS/MS method was successfully applied to the evaluation of pharmacokinetic parameters of lansoprazole in beagle dogs. The results indicate that the compound lansoprazole capsule had an advantage of rapid absorption. This study demonstrated that the compound lansoprazole capsule has better gastroprotective activity and that this might be related to its positive influence on oxidative stress and inflammation. This new type of compound lansoprazole capsule may be potentially useful in preclinical therapy.
Sieve Plate Pores in the Phloem and the Unknowns of Their Formation
Authors: Kalmbach Lothar , Helariutta Ykä
Published: January 2019

Sieve pores of the sieve plates connect neighboring sieve elements to form the conducting sieve tubes of the phloem. Sieve pores are critical for phloem function. From the 1950s onwards, when electron microscopes became increasingly available, the study of their formation had been a pillar of phloem research. More recent work on sieve elements instead has largely focused on sieve tube hydraulics, phylogeny, and eco-physiology. Additionally, advanced molecular and genetic tools available for the model species Arabidopsis thaliana helped decipher several key regulatory mechanisms of early phloem development. Yet, the downstream differentiation processes which form the conductive sieve tube are still largely unknown, and our understanding of sieve pore formation has only moderately progressed. Here, we summarize our current knowledge on sieve pore formation and present relevant recent advances in related fields such as sieve element evolution, physiology, and plasmodesmata formation.
Autotoxicity of Diterpenes Present in Leaves of Cistus ladanifer L.
Authors: Chaves Lobón Natividad , Ferrer de la Cruz Irene , Alías Gallego Juan Carlos
Published: January 2019

Cistus ladanifer has been described as an allelopathic and autoallelopathic species, and the compounds that could be involved in its autotoxicity are the flavonoids and diterpenes present in the exudate of its leaves. The aim of this study was to determine which family of compounds, either phenols or terpenes, are responsible for the autoallelopathic activity quantified in C. ladanifer. These compounds were extracted from the exudate of young leaves collected in spring and separated by column chromatography into two fractions: diterpenes and flavonoids. The obtained results showed that flavonoids, at the tested concentrations, did not have a negative effect on any of the parameters quantified in the germination process of C. ladanifer seeds. On the other hand, the germination, seedling size and seedling establishment, quantified through the germination index and rate, were negatively affected by the tested diterpene solutions. In view of the obtained results, it was concluded that the compounds involved in the autoallelopathy process of C. ladanifer are diterpenes.
Conductive Polymer Composites from Renewable Resources: An Overview of Preparation, Properties, and Applications
Authors: Huang Yao , Kormakov Semen , He Xiaoxiang , Gao Xiaolong , Zheng Xiuting , Liu Ying , Sun Jingyao , Wu Daming
Published: January 2019

This article reviews recent advances in conductive polymer composites from renewable resources, and introduces a number of potential applications for this material class. In order to overcome disadvantages such as poor mechanical properties of polymers from renewable resources, and give renewable polymer composites better electrical and thermal conductive properties, various filling contents and matrix polymers have been developed over the last decade. These natural or reusable filling contents, polymers, and their composites are expected to greatly reduce the tremendous pressure of industrial development on the natural environment while offering acceptable conductive properties. The unique characteristics, such as electrical/thermal conductivity, mechanical strength, biodegradability and recyclability of renewable conductive polymer composites has enabled them to be implemented in many novel and exciting applications including chemical sensors, light-emitting diode, batteries, fuel cells, heat exchangers, biosensors etc. In this article, the progress of conductive composites from natural or reusable filling contents and polymer matrices, including (1) natural polymers, such as starch and cellulose, (2) conductive filler, and (3) preparation approaches, are described, with an emphasis on potential applications of these bio-based conductive polymer composites. Moreover, several commonly-used and innovative methods for the preparation of conductive polymer composites are also introduced and compared systematically.
Effect of Operational Conditions on the Behaviour and Associated Costs of Mixed Microbial Cultures for PHA Production
Authors: Cabrera Francisco , Torres Álvaro , Campos José Luis , Jeison David
Published: January 2019

Massive production and disposal of petrochemical derived plastics represent relevant environmental problems. Polyhydroxyalkanoates (PHA) are a renewable alternative that can even be produced from wastes. The production of PHA from acetate using mixed microbial cultures was studied. The effect of two key operational conditions was evaluated, i.e., substrate concentration and cycle length. The effects of these factors on several responses were studied using a surface response methodology. Several reactors were operated under selected conditions for at least 10 solids retention times to ensure stable operation. Results show that conditions providing higher PHA content involve lower biomass productivities. This has a great impact on biomass production costs. Results suggest then that PHA content alone may not be a reasonable criterion for determining optimal conditions for PHB production. If production costs need to be reduced, conditions that provide a lower PHA content in the selection reactor, but a higher biomass productivity may be of interest.
Synthesis of Zwitterionic Copolymers via Copper-Mediated Aqueous Living Radical Grafting Polymerization on Starch
Authors: Fan Yifei , Migliore Nicola , Raffa Patrizio , Bose Ranjita K. , Picchioni Francesco
Published: January 2019

[2-(Methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide (SBMA) is a well-studied sulfobetaine-methacrylate as its zwitterionic structure allows the synthesis of polymers with attractive properties like antifouling and anti-polyelectrolyte behavior. In the present work, we report the Cu0-mediated living radical polymerization (Cu0-mediated LRP) of SBMA in sodium nitrate aqueous solution instead of previously reported solvents like trifluoroethanol and sodium chloride aqueous/alcoholic solution. Based on this, starch-g-polySBMA (St-g-PSBMA) was also synthesized homogeneously by using a water-soluble waxy potato starch-based macroinitiator and CuBr/hexamethylated tris(2-aminoethyl)amine (Me6TREN) as the catalyst. The structure of the macroinitiator was characterized by 1H-NMR, 13C-NMR, gHSQC, and FT-IR, while samples of PSBMA and St-g-PSBMA were characterized by 1H-NMR and FT-IR. Monomer conversion was monitored by 1H-NMR, on the basis of which the reaction kinetics were determined. Both kinetic study and GPC results indicate reasonable controlled polymerization. Furthermore, a preliminary study of the thermal response behavior was also carried through rheological tests performed on aqueous solutions of the prepared materials. Results show that branched zwitterionic polymers are more thermal-sensitive than linear ones.
Synthesis of Uniform Alkane-Filled Capsules with a High Under-Cooling Performance and Their Real-Time Optical Properties
Authors: Liu Jinyun , Wu Yong , Zhang Wen , Long Jiawei , Zhou Ping , Chen Xi
Published: January 2019

Encapsulating under-cooling materials has been a promising strategy to address the compatibility issue with a surrounding matrix. Herein, we present the synthesis of a uniform alkane-infilled capsule system that shows obvious under-cooling properties. As demonstrating examples, n-hexadecane was selected as a liquid alkane and n-eicosane as a solid in our systems as core materials via in-situ polymerization, respectively. The under-cooling properties of capsules were investigated using differential scanning calorimetry, real-time optical observations with two polarizers, and molecular modeling. The n-hexadecane encapsulated capsules exhibited a large under-cooling temperature range of 20 °C between melt and crystallization, indicating potential applications for structure-transformation energy storage. In addition, molecular modeling calculations confirmed that the solid forms of n-hexadecane and n-eicosane are more stable than their liquid forms. From liquid to solid form, the n-hexadecane and n-eicosane release energies were 4.63 × 103 and 4.95 × 103 J·g−1, respectively.
Flame Retardant Behavior of Ternary Synergistic Systems in Rigid Polyurethane Foams
Authors: Xi Wang , Qian Lijun , Li Linjie
Published: January 2019

In order to explore flame retardant systems with higher efficiency in rigid polyurethane foams (RPUFs), aluminum hydroxide (ATH), [bis(2-hydroxyethyl)amino]-methyl-phosphonic acid dimethyl ester (BH) and expandable graphite (EG) were employed in RPUF for constructing ternary synergistic flame retardant systems. Compared with binary BH/EG systems and aluminum oxide (AO)/BH/EG, ATH/BH/EG with the same fractions in RPUFs demonstrated an increase in the limited oxygen index value, a decreased peak value of heat release rate, and a decreased mass loss rate. In particular, it inhibited smoke release. During combustion, ATH in ternary systems decomposed and released water, which captured the phosphorus-containing products from pyrolyzed BH to generate polyphosphate. The polyphosphate combined with AO from ATH and the expanded char layer from EG, forming a char layer with a better barrier effect. In ternary systems, ATH, BH, and EG can work together to generate an excellent condensed-phase synergistic flame retardant effect.
Multiscale and Multi-Granularity Process Analytics: A Review
Authors: Reis Marco S.
Published: January 2019

As Industry 4.0 makes its course into the Chemical Processing Industry (CPI), new challenges emerge that require an adaptation of the Process Analytics toolkit. In particular, two recurring classes of problems arise, motivated by the growing complexity of systems on one hand, and increasing data throughput (i.e., the product of two well-known “V’s” from Big Data: Volume × Velocity) on the other. More specifically, as enabling IT technologies (IoT, smart sensors, etc.) enlarge the focus of analysis from the unit level to the entire plant or even to the supply chain level, the existence of relevant dynamics at multiple scales becomes a common pattern; therefore, multiscale methods are called for and must be applied in order to avoid biased analysis towards a certain scale, compromising the benefits from the balanced exploitation of the information content at all scales. Also, these same enabling technologies currently collect large volumes of data at high-sampling rates, creating a flood of digital information that needs to be properly handled; optimal data aggregation provides an efficient solution to this challenge, leading to the emergence of multi-granularity frameworks. In this article, an overview is presented on multiscale and multi-granularity methods that are likely to play an important role in the future of Process Analytics with respect to several common activities, such as data integration/fusion, de-noising, process monitoring and predictive modelling, among others.
Investigation of Pore-Formers to Modify Extrusion-Spheronized CaO-Based Pellets for CO2 Capture
Authors: Zhang Zonghao , Pi Shuai , He Donglin , Qin Changlei , Ran Jingyu
Published: January 2019

The application of circulating fluidized bed technology in calcium looping (CaL) requires that CaO-based sorbents should be manufactured in the form of spherical pellets. However, the pelletization of powdered sorbents is always hampered by the problem that the mechanical strength of sorbents is improved at the cost of loss in CO2 sorption performance. To promote both the CO2 sorption and anti-attrition performance, in this work, four kinds of pore-forming materials were screened and utilized to prepare sorbent pellets via the extrusion-spheronization process. In addition, impacts of the additional content of pore-forming material and their particle sizes were also investigated comprehensively. It was found that the addition of 5 wt.% polyethylene possesses the highest CO2 capture capacity (0.155 g-CO2/g-sorbent in the 25th cycle) and mechanical performance of 4.0 N after high-temperature calcination, which were about 14% higher and 25% improved, compared to pure calcium hydrate pellets. The smaller particle size of pore-forming material was observed to lead to a better performance in CO2 sorption, while for mechanical performance, there was an optimal size for the pore-former used.
A Window into Africa’s Past Hydroclimates: The SISAL_v1 Database Contribution
Authors: Braun Kerstin , Nehme Carole , Pickering Robyn , Rogerson Mike , Scroxton Nick
Published: January 2019

Africa spans the hemispheres from temperate region to temperate region and has a long history of hominin evolution. Although the number of Quaternary palaeoclimatic records from the continent is increasing, much of the history of spatial and temporal climatic variability is still debated. Speleothems, as archives of terrestrial hydroclimate variability, can help reveal this history. Here we review the progress made to date, with a focus on the first version of the Speleothem Isotopes Synthesis and AnaLysis (SISAL) database. The geology of Africa has limited development of large karst regions to four areas: along the northern coast bordering the Mediterranean, eastern Africa and the Horn of Africa, southwestern Africa and southern Africa. Exploitation of the speleothem palaeoclimate archives in these regions is uneven, with long histories of research, e.g., in South Africa, but large areas with no investigations such as West Africa. Consequently, the evidence of past climate change reviewed here is irregularly sampled in both time and space. Nevertheless, we show evidence of migration of the monsoon belt, with enhanced rainfall during interglacials observed in northeast Africa, southern Arabia and the northern part of southern Africa. Evidence from eastern Africa indicates significant decadal and centennial scale rainfall variability. In northwestern and southern Africa, precession and eccentricity influence speleothem growth, largely through changing synoptic storm activity.
Acknowledgement to Reviewers of QuBS in 2018
Authors:   QuBS Editorial Office
Published: January 2019

Rigorous peer-review is the corner-stone of high-quality academic publishing [...]
Should Governments Tax the Rich and Subsidize the Poor? A Comparative Study of Muslim and Christian Respondents
Authors: McGee Robert W. , Benk Serkan , Yüzbaşı Bahadır
Published: January 2019

This study used the most recent World Values Survey (WVS) dataset to determine whether Christian and Muslim views on the acceptability of taxing the rich and subsidizing the poor was an essential feature of democracy. The sample size included more than 23,000 individuals from more than 50 countries. More than a dozen socioeconomic and attitudinal variables were also examined to determine whether significant differences existed. The study found that differences in viewpoint were often significant.
The Book of Job as a Thought Experiment: On Science, Religion, and Literature
Authors: Fehige Yiftach
Published: January 2019

This paper presents a philosophical critique of the proposal that the Book of Job is a theological thought experiment about divine providence. Eight possible objections are entertained. They guide the discussion of the proposal. It is concluded that the proposal has more merits than perils.
Thermal Conversion of Municipal Biowaste Anaerobic Digestate to Valuable Char
Authors: Nisticò Roberto , Guerretta Federico , Benzi Paola , Magnacca Giuliana , Mainero Davide , Montoneri Enzo
Published: January 2019

The municipal biowaste anaerobic digestate of a typical waste treatment plant is pyrolyzed under a mild condition (i.e., 540 °C) to directly yield N-doped biochar without performing any subsequent functionalization process. The results confirmed the integration of nitrogen heteroatoms within the carbonaceous framework. The morphological characterization, instead, evidenced the formation of a rather dense biochar with a very low surface area.
Risk Model Validation: An Intraday VaR and ES Approach Using the Multiplicative Component GARCH
Authors: Summinga-Sonagadu Ravi , Narsoo Jason
Published: January 2019

In this paper, we employ 99% intraday value-at-risk (VaR) and intraday expected shortfall (ES) as risk metrics to assess the competency of the Multiplicative Component Generalised Autoregressive Heteroskedasticity (MC-GARCH) models based on the 1-min EUR/USD exchange rate returns. Five distributional assumptions for the innovation process are used to analyse their effects on the modelling and forecasting performance. The high-frequency volatility models were validated in terms of in-sample fit based on various statistical and graphical tests. A more rigorous validation procedure involves testing the predictive power of the models. Therefore, three backtesting procedures were used for the VaR, namely, the Kupiec’s test, a duration-based backtest, and an asymmetric VaR loss function. Similarly, three backtests were employed for the ES: a regression-based backtesting procedure, the Exceedance Residual backtest and the V-Tests. The validation results show that non-normal distributions are best suited for both model fitting and forecasting. The MC-GARCH(1,1) model under the Generalised Error Distribution (GED) innovation assumption gave the best fit to the intraday data and gave the best results for the ES forecasts. However, the asymmetric Skewed Student’s-t distribution for the innovation process provided the best results for the VaR forecasts. This paper presents the results of the first empirical study (to the best of the authors’ knowledge) in: (1) forecasting the intraday Expected Shortfall (ES) under different distributional assumptions for the MC-GARCH model; (2) assessing the MC-GARCH model under the Generalised Error Distribution (GED) innovation; (3) evaluating and ranking the VaR predictability of the MC-GARCH models using an asymmetric loss function.
Stepped Frequency Microwave Radiometer Wind-Speed Retrieval Improvements
Authors: Sapp Joseph W. , Alsweiss Suleiman O. , Jelenak Zorana , Chang Paul S. , Carswell James
Published: January 2019

With the operational deployment of the Stepped Frequency Microwave Radiometer (SFMR), hurricane reconnaissance and research aircraft provide near real-time observations of the 10 m ocean-surface wind-speed both within and around tropical cyclones. Hurricane specialists use these data to assist in determining wind radii and maximum sustained winds—critical parameters for determining and issuing watches and warnings. These observations are also used for post-storm analysis, model validation, and ground truth for aircraft- and satellite-based wind sensors. We present observations on the current operational wind-speed and rain-rate SFMR retrieval procedures in the tropical cyclone environment and propose suggestions to improve them based on observed wind-speed biases. Using these new models in the SFMR retrieval process, we correct an approximate 10% low bias in the wind-speed retrievals from 15 to 45 m s −1 with respect to GPS dropwindsondes. In doing so, we eliminate the rain-contaminated wind-speed retrievals below 45 mm h −1 at tropical storm- and hurricane-force speeds present in the current operational model. We also update the SFMR radiative transfer model to include recent updates to smooth-ocean emissivity and atmospheric opacity models. All corrections were designed such that no changes to the current SFMR calibration procedures are required.