bluuebunny/crossref_metadata_2025 huggingface dataset:
Erratum: Media Pembelajaran Ular Tangga dalam Keterampilan Dasar Dribbling Bola Basket
Authors: Rusmana Ruslan , Tangkudung James , Dlis Firmansyah
Published: April 2020

Correction to: JUARA: Jurnal Olahraga

 

https://doi.org/10.33222/juara.v4i2.527

 

This article was originally published using English metadata in the article title and this is our fault. but now the article metadata has been changed in Indonesian and appears correctly in the current article.
Erratum: Hubungan Kekuatan Lengan, Koordinasi Mata Tangan, Dan Fleksibilitas terhadap Keterampilan Forehand Drive
Authors: Kusuma Rizki Ridha
Published: April 2020

Correction to: JUARA: Jurnal Olahraga

 

This corrects the article DOI: https://doi.org/10.33222/juara.v4i2.546

 

This article was originally published using English metadata in the article title and this is our fault. but now the article metadata has been changed in Indonesian and appears correctly in the current article.
Erratum: Pengaruh Media Pembelajaran Dan Koordinasi Terhadap Ketepatan Forehand Top Spin Tenis Meja
Authors: Subagja Diki Syafwan , Kusmaedi Nurlan , Komarudin Komarudin
Published: April 2020

Correction to: JUARA: Jurnal Olahraga

 

https://doi.org/10.33222/juara.v4i2.619

 

This article was originally published using English metadata in the article title and this is our fault. but now the article metadata has been changed in Indonesian and appears correctly in the current article
Erratum: Hubungan Kecerdasan Emosional dan Self-Efficacy Dengan Penguasaan Teknik Roll Kayak Slalom
Authors: Rahman Ramdhani , Kusmaedi Nurlan , Komarudin Komarudin
Published: April 2020

Correction to: JUARA: Jurnal Olahraga

 

https://doi.org/10.33222/juara.v4i2.628

 

This article was originally published using English metadata in the article title and this is our fault. but now the article metadata has been changed in Indonesian and appears correctly in the current article.
Creative Labor: Distinctive Aspects, Dynamics of Development and Characteristics of System Transformation
Authors: Khabibullina Zenfira R.
Published: April 2020

Based on the theory of noonomy developed by S. D. Bodrunov, the author covers the possibilities of its use in studying a range of issues addressed under the Marxist paradigm, in particular when it comes to creative, universal labor. The author demonstrates an abiding role of labor in the economic development. The paper reveals changes of the creative worker place, role and value caused by modern technological transformations. The author delves into the need of addressing the social utility of creative labor and importance of studying its value in use. The paper presents the author's vision of the dynamics of the new forms of personal production factor development in a context of increasing importance of knowledge and competence.It is known that the labor subject is gradually transformed from a tool for material assets creation into the goal and condition of its own enlarged reproduction and qualitative internal improvement as the society shifts to a higher stage of technological development. As a result, the worker that mostly operates a highly intelligent creative element in his activity starts restructuring the existing relations system with the capital owner.This leads to the assumption that the new form of participation allows a creative worker to get back the self-organization property and self-sufficiency of the labor process which he had lost meanwhile restoring an almost equal negotiation power in course of interaction with capital. This gives grounds for firm background for the situation when the creative labor unit, on the one hand, and the capital owner, on the other, start to interact as partners and coworkers. But because the hired labor of the creative worker still prevails in the framework of the capitalist market system, it is at least premature to debate about the rapid overcoming of the economic dependence of labor on capital.
Perilaku Deteksi Dini Kanker Serviks Melalui Metode Pemeriksaan Inspeksi Visual Asam Asetat (IVA) pada Mahasiswa Magister FKM UI Menurut Teori Proceede – Preceede Tahun 2019
Authors: Aprilla Gabe Gusmi , Purwanana Rachmadhi
Published: April 2020

Latar belakang: Tujuan: Untuk mengetahui perilaku deteksi dini kanker serviks melalui pemeriksaan Inspeksi Visual Asam Asetat (IVA) pada Mahasiswa Magister FKM UI Tahun 2019.Metode: Desain penelitian ini adalah penelitian kualitatif dilakukan di Fakultas Kesehatan Masyarakat Universitas Indonesia (FKM UI) pada bulan April 2019 terhadap 6 orang mahasiswi Magister FKM UI dengan teknik non probability sampling dalam hal ini adalah purposive sampling, suami mahasiswi dan bidan. Hasil: Perilaku pemeriksaan IVA mahasiswi Magister FKM UI Angkatan 2018 sudah bagus karena sudah banyak yang telah melakukan pemeriksaan IVA dan yang belum pemeriksaan IVA dikarenakan telah melakukan pemeriksaan papsmear meskipun ada juga yang masih malu dan takut melakukan pemeriksaan tersebut. Pengetahuan mahasiswi Magister FKM UI Angkatan 2018 tentang pemeriksaan IVA sudah cukup bagus karena telah mampu menjelaskan dengan baik dan beragam mengenai kanker serviks, ciri-ciri, penyebab, deteksi dini, pemeriksaan IVA dan prosedurnya. Mahasiswi Magister FKM UI Angkatan 2018 telah memiliki sikap positif terhadap pemeriksaan IVA meskipun masih ada yang merasa takut dan risih dengan pemeriksaan tersebut. Keterpaparan informasi mahasiswi Magister FKM UI Angkatan 2018 tentang pemeriksaan IVA sudah cukup bagus khususnya yang bersumber dari media sosial. Dukungan tenaga kesehatan dalam pemeriksaan IVA menurut mahasiswi Magister FKM UI Angkatan 2018 belum maksimal dilakukan. Fasilitas pemeriksaan IVA bagi mahasiswi Magister FKM UI Angkatan 2018 mudah karena tersedia di fasilitas kesehatan terdekat di daerah masing-masing dengan biaya gratis bagi pengguna BPJSKesimpulan: Perilaku, pengetahuan dan keterpaparan informasi dalam pemeriksaan IVA pada mahasiswa sudah cukup bagus, sedangkan dukungan tenaga kesehatan dalam pemeriksaan IVA menurut mahasiswa belum maksimal.Kata kunci: Kanker Serviks, Pemeriksaan Inspeksi Visual Asam Asetat, Proceede – Preceede
Repolarisation Descriptors and Heart Rate Variability in Hemodialysed Patients
Authors: POULIKAKOS D. , BANERJEE D. , MALIK M.
Published: April 2020

T wave morphology (TWM) descriptors derived from Holter electrocardiograms during hemodialysis (HD) are of potential value for cardiac risk assessment in HD patients. Our knowledge on autonomic regulation of TWM descriptors is limited. The purpose of this study was to investigate the association between TWM parameters and heart rate variability (HRV) during intradialytic monitoring. In each of 81 patients on maintenance HD, continuous electrocardiograms were recorded 5 times during HD on alternate weeks. TWM descriptors were calculated every 5 s in overlapping 10-s ECG segments and Low Frequency (LF) (0.04 Hz to 0.15 Hz), High Frequency (HF) (0.15 Hz to 0.40 Hz) powers of the spectrum of HRV were calculated every five min. The calculated values of TWM and HRV were averaged during the first hour of the recordings and subsequently over all recordings in each subject. Analyzable data for HRV and TWM were available in 71 HD patients (aged 61±15, 36 % diabetics, 32 % females). LF in normalized units correlated positively with Total Cosine R to T (r=0.374, p=0.001) and negatively with T wave morphology dispersion (r=−0.253, p=0.033) after adjusting for heart rate. A heart rate independent association between repolarisation descriptors and HRV exists in HD patients. Autonomic modulation needs to be considered when using TWM characteristics for risk profiling of HD patients.
Heat-Shock-Induced Glucose Transporter 4 in the Slow-Twitch Muscle of Rats
Authors: WU P.-F. , LUO S.-C. , CHANG L.-C.
Published: April 2020

In this study, lipoic acid and heat shock treatments were applied to C2C12 myotubes and Sprague-Dawley rats to investigate changes in the heat shock protein 70 (HSP70) and glucose transporter 4 (GLUT4) in 4 different skeletal muscle groups. The results of western blotting indicated that treatment of lipoic acid for 24 h, heat-shock and combined lipoic acid and heat-shock which all increased the level of HSP70 substantially in C2C12 myotubes. However, either lipoic acid or heat-shock did not increase the level of GLUT4 in C2C12 myotubes. In an in vitro migration assay, lipoic acid increased wound migration only when it was applied for 3 h. Moreover, our in vivo results revealed that lipoic acid did not increase HSP70 and GLUT4 in all 4 different skeletal muscles. Furthermore, heat-shock increased HSP70 in all 4 different muscle groups, and heat-shock treatment alone increased the GLUT4 in the soleus muscle only, suggesting that the GLUT4 increased by heat-shock was slow-twitch muscle specific. Collectively, our results indicated that heat-shock is critical factor that modulates GLUT4 and HSP70 in the skeletal muscle of rats.
Captopril Partially Decreases the Effect of H2S on Rat Blood Pressure and Inhibits H2S-Induced Nitric Oxide Release From S-Nitrosoglutathione
Authors: DROBNÁ M. , MISAK A. , HOLLAND T. , KRISTEK F. , GRMAN M. , TOMASOVA L. , BERENYIOVA A. , CACANYIOVA S. , ONDRIAS K.
Published: April 2020

We studied the effects of the H2S donor Na2S on the mean arterial blood pressure (MAP) and heart and breathing rates of anesthetized Wistar rats in the presence and absence of captopril. Bolus administration of Na2S (1-4 µmol/kg) into the right jugular vein transiently decreased heart and increased breathing rates; at 8-30 µmol/kg, Na2S had a biphasic effect, transiently decreasing and increasing MAP, while transiently decreasing heart rate and increasing and decreasing breathing rate. These results may indicate independent mechanisms by which H2S influences MAP and heart and breathing rates. The effect of Na2S in decreasing MAP was less pronounced in the presence of captopril (2 µmol/l), which may indicate that the renin-angiotensin system is partially involved in the Na2S effect. Captopril decreased H2S-induced NO release from S-nitrosoglutathione, which may be related to some biological activities of H2S. These results contribute to the understanding of the effects of H2S on the cardiovascular system.
Acute and Chronic Role of Nitric Oxide, Renin-Angiotensin System and Sympathetic Nervous System in the Modulation of Calcium Sensitization in Wistar Rats
Authors: BRUNOVÁ A. , BENCZE M. , BEHULIAK M. , ZICHA J.
Published: April 2020

Principal vasoactive systems – renin-angiotensin system (RAS), sympathetic nervous system (SNS), nitric oxide (NO) and prostanoids – exert their vascular effects through the changes in calcium levels and/or calcium sensitization. To estimate a possible modulation of calcium sensitization by the above vasoactive systems, we studied the influence of acute and chronic blockade of particular vasoactive systems on blood pressure (BP) changes elicited in conscious normotensive rats by acute dose-dependent administration of Rho-kinase inhibitor fasudil. Adult male chronically cannulated Wistar rats were used throughout this study. The acute inhibition of NO synthase (NOS) by L-NAME enhanced BP response to fasudil, the effect being considerably augmented in rats deprived of endogenous SNS. The acute inhibition of prostanoid synthesis by indomethacin modified BP response to fasudil less than the acute NOS inhibition. The chronic NOS inhibition caused moderate BP elevation and a more pronounced augmentation of fasudil-induced BP changes compared to the effect of acute NOS inhibition. This indicates both short-term and long-term NO-dependent attenuation of calcium sensitization. Long-term inhibition of RAS by captopril caused a significant attenuation of BP changes elicited by fasudil. In contrast, a long-term attenuation of SNS by chronic guanethidine treatment (in youth or adulthood) had no effect on BP response to fasudil, suggesting the absence of SNS does not affect calcium sensitization in vascular smooth muscle of normotensive rats. In conclusion, renin-angiotensin system contributes to the long-term increase of calcium sensitization and its effect is counterbalanced by nitric oxide which decreases calcium sensitization in Wistar rats.
RESPON PERTUMBUHAN TANAMAN DAN HASIL BEBERAPA VARIETAS PADI SAWAH TADAH HUJAN (Oryza sativa L.) AKIBAT PENERAPAN TEKNOLOGI
Authors: Ratnawati Ratnawati , Alfandi Alfandi , Sungkawa Iman
Published: April 2020

Rainfed land with an area of 1.4 million ha is the second rice barn after irrigation land for Indonesia. Understanding rainfed land is land that has a bund but cannot be irrigated with a certain height and time continuously. Therefore the irrigation of rainfed land is largely determined by rainfall so that the risk of drought often occurs in the area during the dry season. So far, rice varieties for rainfed land that have resistant properties to blast disease are still very limited. On the other hand, it is very necessary to diversify the resistant varieties of blast disease to overcome the disease so that the resistance genes are not easily broken. Therefore we need a number of varieties with a wide diversity of resistance genes that are recommended for planting by farmers. The Agricultural Research and Development Agency has released drought-tolerant rainfed lowland rice varieties and several pests and diseases such as Inpari 10, inpari 38, inpari 40, inpari 42, inpari 43 and HHZ5-DT1-DT1 lines. The research method used was Factorial RGD with the treatment of PTT application and conventional technology interacted with rice varieties.The results showed that the application of PTT technology had a real / good influence compared to conventional technology on the growth and yield of rice plants. PTT can increase production by 5.9% and income by 12.6%. Inpari 42, Inpari 43 and HHZ5-DT1-DT1 varieties are relatively more stable than other varieties and Inpari 43 has a higher production compared to other varieties.
POLA PENGGUNAAN OBAT ANTIRETROVIRAL (ARV) PADA RESEP PASIEN RAWAT JALAN DARI KLINIK HIV/AIDS SALAH SATU RUMAH SAKIT SWASTA DI KOTA BANDUNG
Authors: Anggriani Ani , Lisni Ida , Liku Olga Susana
Published: April 2020

ABSTRACT

The Human Immunodeficiency Virus (HIV) continues to be a major global public health issue, which targets the human immune system. The using of ARVs in the treatment of HIV / AIDS increased life expectancy for PLHIV (People With HIV / AIDS). This study aims to determine the description of the using of ARV drugs in outpatients of the HIV / AIDS Clinic and assessed their suitability with established treatment standards. This research was carried out in a descriptive non-experimental manner, with data collection carried out retrospectively, used patient prescription data from April to December 2017. The results of quantitative studies showed 87% were male patients, and the largest age group was 20-29 years (39%) . Class of antiretroviral drugs used were Nucleoside / Nucleotide Reverse Transcriptase Inhibitors (NRTIs), Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs), and Protease Inhibitors (PI), with a combination of antiretroviral drugs most was the combination of first-line tenofovir + lamivudine + efavirenz (69%) while the second-line drug zidovudine + lamivudine + lopinavir / ritonavir  was 1%. The most commonly used comorbid drug was cotrimoxazole. For qualitative data, the accuracy of combination and dose of ARV drugs was 100% in accordance with Permenkes No. 87/ 2014, with 79% of patients adhered to antiretroviral treatment every month. The potential for most ARV drug interactions with other drugs for the moderate category was zidovudin + cotrimoxazole (11%) which occured pharmacokinetically by decreasing renal clearance of zidovudine and glucuronide metabolites. In conclusion, the pattern of used of ARV drugs had met the standard of Permenkes No.87/2014, with the most used were the first line combination of tenofovir + lamivudine + efavirenz.
Formulasi Dan Uji Aktivitas Anti Bakteri Masker Gel Peel-Off Ekstrak Daun Pacar Air (Impatiens balsamina linn.) Dengan Kombinasi Basis PVA dan HPMC
Authors: Saputra Sony Andika , Lailiyah Munifatul , Erivina Adella
Published: April 2020

Peel-off gel mask is one of the practical masks, because after dry the mask can be directly removed without rinsing. In this research, a peel-off gel mask formulation from a pacar air leaf extract (Impatiens balsamina Linn.) Has antibacterial activity against Staphylococus Aureus bacteria. The peel-off gel mask is prepared in 3 formulas by varying the PVA and HPMC concentrations of F1 (1: 2,6), F2 (1: 3), F3 (1: 3,5). Evaluation of gel quality used is organoleptic test, viscosity, adhesion, drying time, dispersion, pH. Testing of antibacterial activity was done by using the diffusion method of wells. The positive control used was clindamycin phosphate 1.2%, the negative control used was the base of the peel-off gel mask. Results of physical evaluation and antibacterial activity test were analyzed using SPSS software with trust level of 0.05. Based on the results obtained F3 is the optimum formula, because F3 has a corresponding pH of 5.2 ± 0.10, the corresponding depth of 6.85 ± 0.13, the fastest drying time of 21.68 ± 0.33 and the anti-activity the best bacteria. Based on testing of antibacterial activity of F1, F2 and F3 have antibacterial activity against Staphylococus Aureus bacteria.
PERBANDINGAN UJI DAYA HAMBAT ANTARA EKSTRAK AKAR BELUNTAS DENGAN KULIT BUAH MAHKOTA DEWA TERHADAP PERTUMBUHAN BAKTERI E.COLI
Authors: Agustina Ika , Efrilia Mega , Lisnawati Nia
Published: April 2020

When this has been much studied extracts of herbs or traditional medicines, among other crops beluntas (Pluchea indica Less) and mahkota dewa (Phaleria macrocarpa (Scheff.) Boerl.) As an antibacterial. Previous research has suggested that the rind of the gods crown and root beluntas known to have antibacterial activity, but please be more certain with the same methods and evaluation in testing the antibacterial activity of both plants against bacteria Escherichia coli. Are both these plants have a vigorous activity the same or different from one another. The method used to test the antibacterial activity is using the disc. The results showed beluntas root extract has inhibitory activity against Escherichia coli was higher than fruit skin extracts gods crown with a minimum concentration of 6%, while the fruit skin extracts crowns a new god looks at a concentration of 12%. Based on the paired t-test showed that there is a significant difference between the antibacterial activity of root extracts beluntas with fruit leather crown god.
The Character of J.S.Mill
Authors: Pratt Vernon
Published: April 2020

J.S. Mill introduces a new conception of a person’s character as the control system governing choice of action in, as he thought of it, the human deterministic machine. Did this leave any room for him to think that a person was nevertheless essentially different from the ‘automatons’ of his time? Yes. Mill thought of the human ‘machine’ as featuring ‘feedback’: and, foreshadowing the electronic feedback circuits of early electronic computers, this allowed him to think of human beings as working their way automatically towards Utopia. Mill’s term for what he thinks of as the bit of human ‘machinery’ responsible for ‘deciding’ what action to take is: ‘character’. The Millian ‘control system’ character was taken up widely in the 19th Century and beyond. Illustrative examples: William Temple, Thomas Arnold, Stowe, George Eliot, The Millian sense of character is modified but hardly superseded in subsequent decades.
Soybean Seed Vigor: Uniformity and Growth as Key Factors to Improve Yield
Authors: Ebone Luciano Antônio , Caverzan Andréia , Tagliari Alberto , Chiomento José Luís Trevizan , Silveira Diógenes Cecchin , Chavarria Geraldo
Published: April 2020

Emergence uniformity and the time required for emergence are essential factors for obtaining highly productive potential in plants. Factors such as sowing depth and soil moisture affect uniformity and emergence, but little is known about the impacts of seed vigor. Thus, we determined the impacts of seed vigor on uniformity and growth as well as development and yield in soybean (Glycine max [L.] Merrill) plants. The treatments consisted of four vigor levels (89%, 57%, 47%, and 43%) obtained by accelerated aging, in a randomized block design, with five replicates at three sites. Seeds with the highest vigor level showed higher uniformity and faster emergence. Dominated plants through their phenotypic plasticity modify stem diameter and internode length. The plants that emerged earlier had a larger leaf area in the three stages (V1, V4, and R2), allowing them to accumulate more photoassimilates in the initial stages. Consequently, these plants exhibited an increase in yield components, especially in the number of fertile nodes and the number of pods per plant, making them more productive.
“Patrolling Normative Borders after the Black Death: The Bishop of Lucca’s Criminal Court,” in Center and Periphery: Studies on Power in the Medieval World in Honor of William Chester Jordan, ed. Katherine L. Jansen, G. Geltner, and Anne E. Lester. Leiden: Brill, 169-80
Authors: Geltner Guy
Published: April 2020

Surveys and analyzes Lucchese bishop's earliest criminal court records.
Antifraternal Polemics: Between Literature and Social Reality
Authors: Geltner Guy
Published: April 2020

In: Francesco e i frati minori nello specchio dell’Europa, Proccedings of the 42nd Conference of Franciscan Studies, Assisi (17-19 October 2014), 313-31
“La prison urbaine: pratiques civiques, discourse religieux et enjeu social,” in Enfermements. La cloître et la prison (Ve – XVIIIe siècle), ed. Isabelle Heullant-Donat, Julie Claustre, and Elisabeth Lusset. Paris: Publications de la Sorbonne, 321-30
Authors: Geltner Guy
Published: April 2020

Examination of medieval prisons as political and religious disciplinary space
Experimental rat models for contrast-induced nephropathy; a comprehensive review
Authors: Perera Marlon , Ischia Joseph , Bolton Damien , Shulkes Arthur , Baldwin Graham S. , Patel Oneel
Published: April 2020

Contrast-induced nephropathy (CIN) is an iatrogenic disease caused by the parenteral administration of iodinated contrast media (CM). A number of agents are currently being assessed to minimise or prevent CIN. Such agents are typically assessed using rat models. The aim of this study was to provide a comprehensive review of the rat models of CIN used in pre-clinical research. The MEDLINE, EMBASE, Web of Science and Cochrane databases were systematically searched. Articles reporting rat models of CIN were included for assessment. Study designs, contrast agents and outcome measures were assessed. Of the assessed studies, a majority report a requirement for pre-existing renal impairment prior to the administration of CM. Outcome measures are heterogenous between studies, but typically include assessment and quantification of serum biochemical markers, cellular oxidative stress and histopathological changes. The significant variation in methodology reported in the current literature highlights the lack of consensus. The use of a reliable pre-contrast insult appears critical to result in the development of contrast nephropathy. The use of acceptable outcome measures appears to include serum laboratory markers, quantification of reactive oxygen species (ROS) and objective histopathological outcomes.
Effect of sirolimus as an immunosuppressive agent on kidney transplantation in patients with diabetes mellitus; a systematic review
Authors: Davar Saeedeh , Mohammad Rahimi Mohsen , Akhgar Maasoumeh Mahdi , Saei Sajjad
Published: April 2020

Introduction: Sirolimus is a macrolide and a type of immunosuppressant drug to prevent rejection of transplanted organs. This drug inhibits the activation of T and B lymphocytes and reduces the production of interleukin-2 (IL-2). Objectives: This study aimed to review the effect of sirolimus in kidney transplantation in patients with diabetes mellitus as a systematic review. Materials and Methods: International databases including PubMed, Web of Science and Scopus were considered for search of English articles by 29 June 2019. Twenty-one published articles were finally entered into the study. Keywords were sirolimus, rapamune, rapamycin, diabetes mellitus and kidney transplantation or a combination of them in the title/abstracts. Treatment using a combination of sirolimus and tacrolimus were excluded. Results: There were more than 3244 subjects reviewed in this systematic review including 21 published articles (Total population of 21 articles: 3244 people). Conclusion: According to the results, sirolimus-based immunosuppression for preventing kidney transplantation is effective and has a low-risk in diabetic patients resulting in suitable glucose control.
Renal allograft survival in transplant recipients with focal segmental glomerulosclerosis
Authors: Shinzato Takahiro , kinoshita Yoshitaka , Kubo Taro , Shimizu Toshihiro , Nanmoku Koji , Yagisawa Takashi
Published: April 2020

Introduction: The frequency that idiopathic focal segmental glomerulosclerosis (FSGS) recurs in renal allografts is reportedly 20-50%, but the epidemiology of secondary FSGS in this setting has scarcely been addressed. Objectives: The aim of this study was to examine the incidence, etiology, and subtypes of FSGS in renal allograft recipients and allograft survival in recipients with FSGS. Patients and Methods: As a retrospective review, we examined medical records of 359 consecutive renal allograft recipients (living donors, 329; cadaveric donors, 30). In 121 of these patients, allograft dysfunction or proteinuria prompted biopsies. We compared allograft survival in recipients with and without FSGS. We then determined histologic subtypes of FSGS using the Columbia classification and categorized FSGS as recurrent or de novo, and idiopathic or secondary. Results: Of 121 subjects who were biopsied, six with inadequate specimens (<10 glomeruli) were excluded. Only 17 of those remaining (n=115) were diagnosed as secondary FSGS. Renal allograft survival did not differ significantly in patients with or without FSGS (P=0.953). Subtypes of FSGS were as follows; not otherwise specified (NOS; n=8), collapsing (n=5), cellular (n=2), and perihilar (n=2). Conclusion: Secondary FSGS was observed in 14.5% of biopsies of renal allograft recipients and seemed no significant impact on allograft survival.
The role of parathyroid hormone and cardiac output in pulmonary hypertension in hemodialysis patients
Authors: Mortazavi Moghaddam Sayyed golamreza , Azdaki Nahid , Golgoon Mina , Ramazani Abbas ali , Saremi Zainab
Published: April 2020

Introduction: High prevalence of pulmonary hypertension has been reported in patients with chronic renal failure, especially those undergoing hemodialysis. Objectives: Considering the high prevalence of pulmonary hypertension in hemodialysis patients and uncertainty about the causes, the present study planned to investigate the role of parathyroid hormone (PTH) and cardiac ejection fraction (EF %) in development of pulmonary hypertension. Patients and Methods: By simple census sampling, all patients on hemodialysis in the hemodialysis center of Birjand University of Medical Sciences were enrolled. After obtaining written consent, the EF% and systolic pulmonary artery pressure (sPAP) were determined using echocardiography (MEDISON V10 model, Korea). The cut-point of less than 35 mm Hg was considered for normal sPAP. The blood sample was prepared to assay PTH using COBAS411 and ROCH kit. Independent t test or Man-Whitney test were used to compare means. P value <0.05 was considered significant. Results: A totsl of 114 patients were enrolled in the study. Finally 89 patients, including 49 (55.1%) male and 40 (44.9%) female completed the study. The mean age and mean sPAP of the studied patients were 55.14 ± 15.68 years and 30.65 ± 12.10 mm Hg respectively. Among the studied patients, normal and high sPAP were reported in 60 (67.4%) and 29 (32.6%) cases respectively. Cardiac EF% in patients with normal and high sPAP was 59.08 ± 2.83 versus 56.37 ± 4.79 respectively (P = 0.01). PTH was determined 275.12 ± 218.44 versus 395.67 ± 332.05(pg/mL) (P = 0.03), in patients with normal and high sPAP respectively. Conclusion: The prevalence of pulmonary hypertension in the studied patients was 32.6%. Patients in the pulmonary hypertension group had higher levels of PTH and lower cardiac EF%.
A case of Fanconi syndrome as a complication of treatment with a checkpoint inhibitor in a patient with hepatocellular carcinoma
Authors: Tinawi Mohammad , Bastani Bahar
Published: April 2020

Introduction: Immune checkpoint inhibitors (CPIs) represent novel new cancer immunotherapy agents. The use of nivolumab has been linked with immune mediated acute interstitial nephritis (AIN). Case Presentation: We present the case of a patients with recurrent hepatocellular carcinoma who developed severe Fanconi syndrome, as evidenced by hyperchloremic metabolic acidosis, hypokalemia, hypophosphatemia, glucosuria, aminoaciduria, 8 months after initiating treatment with nivolumab, without any evidence of acute renal insufficiency. Conclusion: Clinicians need to be aware of the renal side effects of new novel cancer immunotherapy agents, such as, immune CPIs
Painful angiomyxoid tumor in a failed renal allograft presenting as post-transplant lymphoproliferative disorder
Authors: Dreher Paulette Cutruzzula , Fazendin Jessica M. , Lurz Kelly , Edwards Daniel C. , Guy Stephen , Amster Melanie
Published: April 2020

Introduction: There exist few reports of de novo tumors involving an allograft kidney, and to the best of our knowledge there are only two previous reports of angiomyxoma Case Presentation: A 53-year-old Caucasian male with end-stage renal disease (ESRD) on hemodialysis (HD) secondary to malakoplakia with three failed prior renal transplants presented for repeat transplant evaluation. Imaging demonstrated a mass of the transplanted kidney suggestive of posttransplant lymphoproliferative disease (PTLPD). A biopsy was obtained revealing a predominance of myxoid material. The patient became increasingly symptomatic from the mass and underwent a palliative right transplant nephrectomy. Final pathology revealed angiomyxoid tumor. Conclusions: Angiomyxomas are asymptomatic, appear as PTLD on imaging and should be considered in the differential diagnosis of masses occurring in renal transplant allografts.
Is physical activity related to renal cell carcinoma? A systematic review
Authors: Mahdavi Nader , Hosseinpour Parisa , Dashti Golnaz , Bouzari Behnaz , Valizadeh Rohollah , Hassanlouei Babak
Published: April 2020

Introduction: Relationship between renal cell carcinoma and physical activity is not clear. Objectives: This study aimed to review the relationship between renal cell carcinoma and physical activity. Methods: We searched valid databases such as PubMed/Medline, Web of Science and Scopus for search of English papers by 30/12/2018. Eleven articles were selected for final assessment. We used Kidney cancer, Exercise, Kidney Neoplasm, Renal cancer, Physical activity, Renal cell carcinoma, Physical inactivity and Sedentary Lifestyle or a combination of them in the title/abstracts as the keywords. Results: There were 37,742 subjects reviewed in this systematic review of eleven published papers including five standard case-control, three cohorts and three population-based case-control design. Conclusion: According to the results, physical activity has a reverse relationship with renal cell carcinoma.
The association of serum dephosphorylated-uncarboxylated matrix gamma carboxyglutamate protein (dp-ucMGP) as a marker of vascular vitamin K status with allograft function in kidney transplant recipients
Authors: Ebrahimzadeh Attari Vahideh , Shahvegharasl Zahra , Fathalizadeh Pouya , Pourasghary Sajjad , Mohajel Shoja Mohammadali , Niknafs Bahram , Ardalan Mohammad Reza
Published: April 2020

Introduction: Kidney transplantation has considerably increased the survival and life quality of patients with end-stage renal disease. Objectives: The current study was designed to investigate the circulating level of dephosphorylateduncarboxylated matrix gamma carboxyglutamate protein (dp-ucMGP) as a marker of vitamin K status and vascular calcification in kidney transplant recipients as well as its association with the allograft function. Patients and Methods: In this cross-sectional study, 90 eligible kidney transplant recipients were evaluated in the post-transplant phase (about 6-12 months after kidney transplantation). The serum levels of dp-ucMGP, urea, creatinine and other biochemical indices were determined. Results: The mean serum level of dp-ucMGP was 3.78±3.79 µg/L. Most of the participants (80%) had a normal range of serum dp-ucMGP (<4 µg/L). However, 10 % had high serum dp-ucMGP (>12 µg/L). Serum dp-ucMGP did not have any statistical significant association with serum urea, creatinine and kidney function (P>0.05). Conclusion: Further epidemiologic studies are needed to assess the time trends of dp-ucMGP after renal transplant and its relation to kidney function, since high serum level of dp-ucMGP may make kidney transplant recipients prone to various cardiovascular disease (CVD) and transplant rejection.
ٍEvaluation of attention and memory function in hemodialysis patients; a study based on hemodialysis duration
Authors: Alidadi Ali , Bakhshani Nour-Mohammad , Sabayan Behnoush , Ansari-Moghadam Alireza
Published: April 2020

Introduction: End-stage renal disease (ESRD) is one of the health problems in today’s world. Neuropsychological problems are more common in hemodialysis (HD) patients than in healthy individuals. Objectives: The aim of this study was to investigate the effect of long-term HD on memory function of these patients. Patients and Methods: Our study, included 80 HD patients of whom 39 were under 6 months of HD and 41 patients as another group which had a history of HD more than 6 months. Results: The population had a mean age of 51.60 years old (27.5% female). The scores of patients who have been hemodialyzed for a long-time (median time of HD was up to 4 years) had lower score in forward digit (FD), backward digit score test (BD), letter digit modality task (LDMT), letter symbol digit modality task (LSDMT) (5.49; 3.61; 21.12; 17.66) than the HD patients who underwent HD for a shorter term, with the median time of 3 to 5 months (7.38; 4.79; 39.77; 43.38) (P<0.001). Conclusion: The present study demonstrated that end-stage HD patients who were under HD for a long time had significantly lower scores in the memory and attention tests. However, additional researches are needed in this area.
Investigation of the presence of G354A (Cys87Tyr) mutation in osteoprotegerin gene in women with osteoporosis in Chaharmahal and Bakhtiari province
Authors: Mousavi Seyedeh Zahra , Dehghan Morteza , Pourahmad Razieh
Published: April 2020

Background and aims: Osteoprotegerin (OPG) is a competitive inhibitor of the differentiation and activity of osteoclasts, which inhibits the final stages of osteoclast formation and induces its apoptosis. In addition, OPG is considered as one of the most important candidate genes in the pathogenesis of bone diseases such as osteoporosis and idiopathic hyperphosphatasia. The G354A (Cys87Tyr) mutation in the OPG gene leads to idiopathic hyperphosphatasia. This mutation is probably related to osteoporosis. The purpose of this study was to investigate the presence of G354A (Cys87Tyr) in women with osteoporosis in Chaharmahal and Bakhtiari province. Methods: In this descriptive-analytical study, the bone mineral density (BMD) of the femoral neck and lumbar spine of women referring to Shahrekord bone densitometry centers was measured by the X-ray absorptiometry technique in 2013-2014. Based on T-scores, people with osteoporosis were identified and 70 patients were enrolled in the study after receiving their consent. Finally, DNA was extracted from blood samples, amplified by polymerase chain reaction (PCR) technique, and sequenced by DNA sequencing method. Results: After DNA extraction from the blood, the quality and quantity were determined by gel electrophoresis and spectrophotometry, respectively. Then, the gene was amplified by the PCR method and the product was detected by gel electrophoresis, followed by sequencing the samples to investigate the presence of the mutation. Eventually, genotypes associated with Cys87Tyr mutation were not observed in the studied population. Conclusion: In the present study, the G354A (Cys87Tyr) mutation associated with idiopathic hyperphosphatasia was not found in women with osteoporosis.
Removal of mercury (II) from aqueous solutions by multiwalled carbon nanotubes coated with manganese oxide
Authors: Khodabakhshi Abbas , Asgarian Hassan
Published: April 2020

Background and aims: Water pollution by heavy metals is one of the most important environmental problems. Among the heavy metals, mercury (Hg) is a very toxic metal and its high concentration can lead to impaired pulmonary and renal dysfunction. The aim of this study was to determine the amount of Hg removal by carbon nanotubes coated with manganese (Mn) oxide from aqueous solutions. Methods: In this study, multi-walled carbon nanotubes coated with Mn oxide were prepared and used to remove Hg from aqueous environments. In addition, the physical and structural characteristics of the nanotubes were determined by the X-ray diffraction (XRD). The impact of diverse variables was further investigated, including the initial concentration of Hg, the initial pH of the solution, contact time, mixing rate, as well as the amount of nano-composite and the impacts of confounders (nitrate and chloride). Finally, optimum conditions for each of these parameters were obtained by the Taguchi statistical method. Results: The XRD analysis showed that the nanotubes were properly coated with Mn oxide. Furthermore, the results demonstrated that under pH 7, the rate of mixing of 150 rpm, the contact time of 60 minutes, the amount of nano-composite of 60 mg, and the initial density of Hg 80 mg/L can be achieved by removing 95% Hg. Moreover, the confounder factors of nitrate and chloride reduced the amount of Hg removal by 4 and 5%, respectively. Conclusion: Based on the results, the nanotubes coated with Mn oxide can be used as easy and strong absorbents for the rapid absorption of Hg from drinking water and industrial wastewater.
Comparison of Momordica charantia effect on Mcl-1 gene expression in the livers of streptozotocin diabetic and healthy rats
Authors: Salehian-Dehkordi Mahsa , Sazegar Hossein
Published: April 2020

Background and aims: The positive effects of medicinal herbs on diabetes have been proved in previous studies. The aim of the present study was to evaluate the effect of active Momordica Charantia on the treatment of liver diseases resulting from diabetes and the expression level of the Mcl-1 gene, which is a proapoptotic gene and becomes antiapoptotic in the event of damage. Methods: In this study, 42 adult male Wistar rats were randomly divided into 7 groups including healthy, diabetic, metformin, 150 mg/kg M. charantia controls, and three groups that received the active M. charantia with doses of 50, 100, and 150 mg/kg. All groups became diabetic with streptozotocin injected intraperitoneally except for the control and M. charantia. Afterward, they received the active M. charantia by gavage for four weeks (three times a week). Finally, the Kruskal-Wallis method was used for comparison among the groups. The statistical tests were analyzed using SPSS software, version 22. Results: The level of Mcl-1 expression in the diabetic control group (C) was significantly higher than that in the healthy control (A) and the M. charantia-receiving control group (B, P<0.05). The group receiving 150 mg/kg dose of M. charantia drug (G) had a better effect compared to the group that received 100 mg/kg (F), and this difference was significant (P<0.05). This increase indicated that the medication was dose-dependent. Conclusion: In general, a reduction in the level of Mcl-1 gene expression relied on the M. charantia dose. After the development of diabetes, this level significantly increased in the diabetic groups, but decreased after receiving M. charantia, leading to a decrease in the side effects and symptoms associated with diabetes.
Comparing the effectiveness of acceptance and commitment therapy and physiotherapy on quality of life and pain catastrophizing in patients with chronic pain
Authors: Ghatreh Samani Mahnaz , Najafi Mahmoud , Rahimian Bouger Issac
Published: April 2020

Background and aims: Chronic pain is a common health problem that affects various aspects of life. Acceptance and commitment therapy (ACT) seems to be helpful in improving the quality of life and pain catastrophizing in patients with chronic pain. The purpose of this study was to compare the efficacy of ACT and physiotherapy on quality of life and pain catastrophizing in patients with chronic pain. Methods: The subjects were 75 women suffering from chronic pain who were considered for physiotherapy. They were randomly divided into 3 groups including ACT, physiotherapy, and control groups. The control group consisted of 25 patients who were on the waiting list for physiotherapy. The first group participated in 8 sessions of ACT, the second group attended 10 sessions of physiotherapy, and the control group received no treatment. The Pain Catastrophizing Scale (PCS) developed by Sullivan et al and the World Health Organization Quality of Life (WHOQOL-BREF) questionnaire were used in this study. Results: The results showed that the quality of life in the ACT group was significantly higher than that in the physiotherapy group and control group (P<0.001). Moreover, there was no significant difference between the ACT and physiotherapy groups in reducing pain catastrophizing (P>0.05), while this difference was significant between the ACT and control groups (P<0.001). Conclusion: In general, ACT leads to a reduction in pain catastrophizing and an increase in the quality of life of patients with chronic pain. Therefore, beside the current therapy like physiotherapy, ACT can be used as another therapeutic choice for patients with chronic pain.
Prediction of probable impact of miR-34a and miR-215 on differentiation of naive CD4+ T cells to Th17 cells in multiple sclerosis
Authors: Ghadiri Nooshin , Hoseini Aref , Ghaedi Kamran , Emamnia Negar Alsadat , Ganjalikhani-Hakemi Mazdak , Navabi Parnian , Shirzad Hedyatollah , Nasr-Esfahani Mohammad Hossein
Published: April 2020

Background and aims: miRNAs, as a class of non-coding RNAs, take part in different cellular processes. Dysregulation of different miRNAs has been reported in numerous disorders to date. Multiple sclerosis (MS) is an autoimmune disease with high prevalence in Iran and Th17 cells play an important role in its pathogenesis. In the current study, we aimed to predict the possible role of miR-34a and miR-215 in the process of controlling Th17 differentiation, and hence, their possible impact on the onset and progression of MS. Methods: We investigated probable interactions of miRNAs and genes that participate in Th17 cells differentiation using miRwalk database as an integrative one which utilizes 10 different algorithms to predict miRNA-mRNA interaction. Results: Based on our findings, miR-34a and miR-215 were predicted to have a potential role in the induction of Th17 cells differentiation. Conclusion: Conclusively, miR-34a and miR-215 may up-regulate Th17 cells of MS patients. Since bioinformatics data have shown that these miRNAs suppress negative regulatory genes in Th17 cells differentiation, we suppose that down-regulation of these miRNAs could ameliorate MS symptoms. Therefore, several therapeutic approaches may be considered for these miRNAs besides their application as valuable prognostic/diagnostic biomarkers in detection of various stages of MS.
Response Surface Methodology for Optimization of Process Variables of Atorvastatin Suspension Preparation by Microprecipitation Method Using Desirability Function
Authors: Maghsoodi Maryam , Montazam Seyed hassan , Rezvantalab Hossein , Jelvehgari Mitra
Published: April 2020

Background
: Atorvastatin (AT), as a synthetic lipid-lowering agent, is a highly crystalline substance having poor solubility and low bioavailability. The objective of the present research was to improve the microprecipitation method of AT suspension preparation. Methods: Microprecipitation parameters were improved using Box-Behnken experimental design method. The suspension was formulated with Brij 35 (stabilizer agent) using methanol as solvent and water as non-solvent, respectively. DSC, XRD, FTIR studies were performed for characterization of the microcrystals. With the aim of evaluating the effect of independent variables, the amounts of organic solvent (X1), emulsifier concentration (X2), stirring rate (X3), and volume of aqueous solvent (X4) on dependent variables, drug content (DC,) particle size (PS), drug released after 5 minutes (Q5), Gibbs free energy change (ΔG°tr), crystal yield (CY) and saturated solubility (Ss), a full factorial was used. Results: The results of DSC, XRD, and FTIR showed that there was not any interaction between AT and Brij 35. This research demonstrated a reduction in crystallinity in agglomerates. The microcrystals showed that micromeritics characteristics were significantly improved compared to pure AT. The content of drug and yield crystal was in the limit of 42.58-110.24% and 58.33-98.18% in all formulations, respectively. It was shown that the prepared microcrystals had a higher rate of release compared to the untreated AT powder (P< 0.05). Size reduction of AT is needed for improving the solubility. Solubility and drug release rates of At was enhanced with the microprecipitation method. Conclusion: The results showed that microcrystals significantly increased AT dissolution rate.
Protective Effects of Selenium in Patients with Beta-Thalassemia Major
Authors: Aboutalebi Ajand , Jouyban Abolghasem , Chavoshi Hadi , Movassaghpour Akbari Aliakbar , Shaseb Elnaz , Sarbakhsh Parvin , Ghaffary Saba
Published: April 2020

Background
: Beta-thalassemia major patients require repeated blood transfusion which is associated with iron overload in different organs such as heart, liver, kidney and their related complications. In this study the effects of selenium in iron overload related complications of patients with beta-thalassemia major were assessed. Methods: In this clinical trial, 34 beta-thalassemia major patients over 12 years old were enrolled. Patients with severe renal failure, history of selenium consumption over the last three months, change of blood transfusion pattern, and any change of chelating agent were excluded from the study. For all patients, tablet of selenium 200 µg/day was administered for a month. Blood samples were taken at baseline and after one-month to assess the level of ferritin, total iron-binding capacity (TIBC), aspartate aminotransferase (AST), alanine aminotransferase (ALT), serum creatinine (Scr), selenium. Hair loss was assessed by questionnaire before and after intervention. Results: From 34 patients, 27 (79.4%) had deficient level of selenium at baseline. The selenium level was increased after intervention (p=0.005). The level of serum ALT and Scr decreased remarkably after one-month selenium consumption (p=0.007 for both). In addition, the AST level decreased remarkably after intervention (p=0.053). Severe hair loss profile has improved significantly after supplementation (p=0.004). Conclusion: One-month selenium consumption improved liver and kidney function related markers remarkably. Moreover, selenium improved hair profile and severe hair loss in thalassemia patients. Further studies are needed on the effect of selenium administration on liver and kidney function.