bluuebunny/crossref_metadata_2025 huggingface dataset:
Lesão por Pressão: uma revisão da prática clínica ao processo de ensino e aprendizagem na graduação de enfermagem
Authors: Albuquerque Rosário de Fátima Alves de , Fregadolli Andrea Marques Vanderlei , Silva Regina Nunes da , Santos Pedro Henrique Albuquerque de Oliveira , Rocha Michele Ribeiro , Oliveira Sofia Evangelista Arruda de , Magalhães Paulyanne Karlla Araújo , Albuquerque Antonia Adriana Alves de , Sales Maria Lucélia da Hora , Santos Geórgia Maria Ricardo Félix dos
Published: July 2022

A Lesão por Pressão constitui-se um sério problema de saúde pública, principalmente em pacientes hospitalizados, afetando sua qualidade de vida com sofrimento físico e emocional, assim como em seus familiares. Gera um impacto significativo nos serviços de saúde, provocando sobrecarga no trabalho dos profissionais, aumento de recursos materiais. Objetiva-se revisar conteúdos sobre a prática clínica da Lesão por Pressão e o processo de ensino e aprendizagem na graduação de enfermagem. Trata-se de uma revisão de literatura realizada 2021, onde foram consultadas legislações (diretrizes, protocolos, guidelines e consensos) sobre a temática Lesão por Pressão, autores de artigos científicos nacionais e internacionais, os quais publicados recentemente (2011 a 2020). As referências foram obtidas nas bibliotecas virtuais (BVS, Scielo, Medline, Google acadêmico, Science Direct, PubMed, Wiley e LILACS), usando os descritores: Lesão por Pressão; conhecimento; enfermagem e estudantes. Após análise do material, foram desenvolvidas quatro categorias temáticas, a saber: nomeclaturas, conceito e classificação; fatores de risco, escala de predição e áreas topográficas; políticas públicas, consensos e intervenções; diretrizes curriculares, formação acadêmica e qualificação profissional dos enfermeiros. No que concerne aos acadêmicos de enfermagem, é importante que haja estímulos para as buscas de atualizações, tanto nas atividades regulares como nas extracurriculares, que ressignifique suas práticas e fomentem uma melhor abordagem desse conteúdo em sua matriz curricular. É necessário, no entanto, que haja interesse das IES em fortalecer o elo integrador entre a teoria e prática que proporcione aos discentes reconhecer-se como gestor do seu processo de ensino aprendizado.
Avaliação do uso irracional de medicamentos por moradores de um bairro de Vitória - PE durante a pandemia do novo Coronavírus
Authors: Costa Artur Vinícius de Lima Montenegro , Anjos Ketly Rodrigues Barbosa dos , Agreles Maria Anndressa Alves , Campos Luís André de Almeida , Cavalcanti Isabella Macário Ferro
Published: July 2022

Esta pesquisa objetiva analisar o comportamento de moradores de um bairro de Vitória de Santo Antão-PE sobre o uso indiscriminado de medicamentos durante o período da quarentena do SARS-CoV-2. Trata-se de um estudo observacional, transversal, com abordagem qualitativa e quantitativa. Os critérios de inclusão foram maiores de 18 anos residentes no bairro Matriz, do município de Vitória-PE e de exclusão indivíduos não alfabetizados. Um questionário de autopreenchimento foi aplicado de forma presencial, com busca ativa dos participantes. Com os resultados obtidos, é possível verificar um padrão de automedicação na população (66,9%) de perfil sociodemográfico representado por mulheres (66,39%), indivíduos na faixa etária de 21-29 anos (33,60%), pardos (42,32%), nível superior completo (29,04%) e RFM entre 1 e 3 salários-mínimos (42,32%). A classe medicamentosa mais utilizada foi anti-inflamatórios (18,1%). Quase 47% se automedicaram como forma de prevenção ao Coronavírus. 65,60% dos entrevistados entendem os riscos do uso inadequado e 66,14% afirmam que a pandemia impactou na automedicação. O SARS-CoV-2 reacendeu debates e discussões s na área da saúde, sendo de suma importância analisar os impactos que a pandemia causou no consumo indiscriminado de medicamentos. Nota-se uma necessidade em desenvolver novas pesquisas sobre esses impactos na população brasileira, bem como estimular a educação em saúde e ao uso racional de medicamentos.
Finding new meaning through music after a suicide attempt
Authors: Alves Andréa Cristina , Pereira Camila Corrêa Matias , Ribeiro Maria Inês Lemos Coelho , Almeida Aline Siqueira de , Carvalho José Carlos , Vedana Kelly Graziani Giacchero
Published: July 2022

Listening to music can trigger unpleasant feelings or bring meaning to our lives, both from the cognitive and psychic perspectives. Thus, music can attribute meanings to our personal experiences and act as a regulator of emotions when living these experiences. Song lyrics can often influence behaviours while helping to work on processes of resilience, autonomy, empowerment, and psychosocial rehabilitation. This study aims to analyse the possibilities of music in the process of resignification of life through the discursive productions of individuals after a suicide attempt. A qualitative study was conducted with eight Brazilian adults assisted in a mental health service, in 2018, through semi-structured interviews. The Symbolic Interactionism theoretical framework was used, and the data were submitted for thematic analysis. Three categories were identified: ‘Spirituality as an empowering agent’; ‘Sense of belonging and identification’, and ‘The importance of music as a sensitizer of reasons for living and an instrument of verbalization of feelings. The study provides important findings that merit further investigation regarding interventions and possibilities related to music as a healing method in the process of resignification of life after a suicide attempt.
Relação entre polimorfismos genéticos e displasia broncopulmonar: uma revisão narrativa
Authors: Santos Neto Teobaldo Ivo dos , Garcia Bianca Portela , Sousa Icaro Araújo de , Nobrega Neto Antônio de Pádua Rocha , Araujo Thiago de Souza Lopes , Souza Luan Kelves Miranda de
Published: July 2022

Polimorfismos genéticos são caracterizados pela variação em sequências específicas de DNA, com a presença de duas ou mais formas variantes em mais de 1% da população. A presença de polimorfismos nem sempre determina o desenvolvimento de uma doença, entretanto, podem influenciar em fatores de risco associados a doenças, como a displasia broncopulmonar (DBP). A DBP é uma doença pulmonar crônica neonatal é caracterizada por uma necessidade de implementação de oxigênio, bem como um suporte ventilatório em nos primeiros 28 dias de vida. Por ser multifatorial, tanto o diagnóstico precoce como o tratamento da DBP é dificultado, o estudo dos polimorfismos genéticos associados à DBP pode ser útil para identificação de alvos moleculares que poderão ser usados para prevenir ou tratar a DBP. O objetivo deste estudo foi realizar uma revisão narrativa acerca da relação entre polimorfismos genéticos e o desenvolvimento de displasia broncopulmonar. Foi realizada uma busca nas bases de dados BVS, PubMed e Scielo utilizando os descritores: “displasia broncopulmonar”, “polimorfismo genético” e “recém-nascido prematuro”. Após a utilização de filtros, resumos e texto dos artigos, selecionou-se 26 artigos para este estudo. Embora o conhecimento sobre a patogênese da DBP tenha aumentado significativamente nos últimos anos, nem todos os mecanismos que levam ao dano pulmonar são completamente compreendidos, explicando a busca por novas abordagens terapêuticas, tais como terapia celular, uso de antioxidantes naturais que têm se mostrado eficazes em estudos preliminaries. Nesta revisão, demonstramos nove polimorfismos que estão relacionados ao aumento do risco de desenvolvimento de DBP por recém-nascidos prematuros.
ADJUSTMENT OF CHINESE UNIVERSITY STUDENTS IN THE CZECH REPUBLIC: THE ROLE OF CULTURAL INTELLIGENCE AND ETHNOCENTRISM
Authors: JURÁSEK MIROSLAV , WAWROSZ PETR
Published: July 2022

The article deals with two factors that affect the process of cross-cultural adaptation of foreigners in the Czech Republic in opposite directions: cultural intelligence (CQ) and ethnocentrism (ETN). Three hypotheses were tested: 1) cultural intelligence and its subdimensions (metacognitive, cognitive, motivational, behavioral) are positively related to intercultural adaptation, 2) ethnocentrism affects adaptation negatively, 3) the positive relationship between CQ and adaptation is weakened by ethnocentrism. The first two hypotheses were confirmed using a PLS-SEM statistical technique on a sample of 84 Chinese students studying at several Czech universities, and the third was rejected. In addition, the latent CQ construct was validated as a hierarchical component model. Means for easier adaptation of students/workers during a long-term stay in a culturally foreign environment are briefly also discussed.
VASIJAS NO CONQUISTADAS. PATRONES DE CONTINUIDAD DE LA CERÁMICA MAYA
Authors: Patzán Dora Maritza García
Published: July 2022

Contact with the Spanish resulted in marked changes in the way of life of the populations of the New World. The production of objects also had to respond to the new system, including new technologies. Ceramics constitute a good example, as a durable and indispensable material for carrying out various tasks, whose production was adapted and merged with the new colonial tradition. However, in several cases the elaboration techniques and other features were maintained. In this contribution, focus is placed on examples of Maya ceramics from the Western Highlands of Guatemala and of the Lacandones from Chiapas, Mexico. Taking into account some important factors such as decorations, forms and manufacturing techniques, as observed, for example, among the Chuj of western Huehuetenango and other communities of the highlands, as well as their spiritual content, as for the Lacandon censers of Chiapas. With regards to colonial ceramics, types exhibiting features of the prehispanic tradition have been identified, as for example, the Late Postclassic Chinautla polychrome type, which was used for funeral urns, a ceramic type that continues to be manufactured in the municipality of Chinautla, Guatemala to this day. This paper identifies the patterns of continuity, their circumstances, conditions, as well as possible generalizations.
Imtaq-Based Solar System Learning in Improving Mastery of Concepts and Religious Attitude Towards Madrasah Tsanawiyah Students
Authors: Widyosari Diana , Pursitasari I. D. , Ardianto D.
Published: July 2022

This experiment research aims to measure the mastery of students’ concepts and religious attitude on solar system learning based on IMTAQ. The research was conducted on class VIII MTsN 22 Jakarta in 2017/2018. The model used in this research is a Problem Base Learning with the research design of pretest posttest control group design. The use of this research design involves two classes as research samples, one experiment class and one control class. The selection of these two classes is done by taking the subject not based on strata, random or regional but based on certain goals. The research subjects were divided into two groups, namely the experiment group and the control group. The experiment grup get Problem Base Learning model based on IMTAQ, while the control grup  just get a Problem Base Learning model. The result of mastery of the concept of the experiment and control class each obtained an average gain of 49.7 and 43.7. This shows that the average pretest score of the two classes is not much different. Increasing the mastery of concepts and religious attitudes of MTsN students on the solar system material can be concluded that the average N-gain in the control class is 0.44% in the medium category, while in the experimental class the average N-gain is 0.50% in the medium category.
Digital Marketing dan Prospek Bisnis Era Covid-19 di Sekolah Menengah Kejuruan (SMK) Hang Nadim Batam
Authors: Elisa Erlin , Handoko Koko , Arista Anggia , Wangdra Yvonne
Published: July 2022

Diera tahun melenial digital marketing sangatlah penting, Digital marketing adalah suatu kegiatan pemasaran atau promosi sebuah brand atau produk menggunakan media digital atau internet. Tujuan digital marketing adalah untuk menarik konsumen dan calon konsumen secara cepat. Seperti yang kita tahu, penerimaan teknologi dan internet di masyarakat sangat luas sehingga tidak heran kegiatan pemasaran secara digital dijadikan pilihan utama oleh perusahaan-perusahaan. Akibatnya, perusahaan saling berkompetisi membuat konten yang menarik untuk ditampilkan dalam pemasarannya di dunia maya. Banyaknya digital marketing yang dipakai oleh perusahaan-perusahaan, membuktikan bahwa Digital Marketing memiliki banyak kelebihan dan manfaat yang dapat diperoleh. Berikut beberapa kelebihan dari Digital marketing dibandingkan dengan pemasaran konvensional. Digital marketing dapat meningkatkan usaha pemasaran bahkan pada era covid-19 saat ini pemanfaatan digital teknologi tersebut menjadikan prospek bisnis baru. Untuk itu dnegan adanya pembinaan ini, diharapkan siswa-siswi terbantu dalam pemahaman tentang pengabdian digital marketing dan prospek bisnis yang baik dan bagus dalam situasi perkembangan IPTEK dan dalam masa sulit saat ini di SMK Hang Nadim Batu Aji Kota Batam. Agar kedepannya siswa-siswi SMK yang telah dibentuk untuk menjadi individu yang siap pakai dapat menentukan karir terutama dibidang wira usaha.
Early Pixel Value Ratios to Assess Bone Healing During Distraction Osteogenesis
Authors: Liu Qi , Mei Haibo , Zhu Guanghui , Liu Ze , Guo Hongbin , Wang Min , Liang Jieyu , Zhang Yi
Published: July 2022

Background: Distraction osteogenesis (DO) is an approach for bone lengthening and reconstruction. The pixel value ratio (PVR), an indicator calculated from X-ray images, is reported to assess the final timing for the external fixator removal. However, the early PVR and its potential influencing factors and the relationship between the early PVR and clinical outcomes are rarely discussed. Therefore, this study was employed to address these issues.

Methods: A total of 125 patients with bone lengthening were investigated retrospectively. The early PVR of regenerated bone was monitored in the first 3 months after osteotomy. The potential effect of sex, chronological age, BMI, lengthening site, and involvement of internal fixation during the consolidation period was analyzed. Moreover, the associations of the healing index (HI) and lengthening index (LI) with early PVR were also investigated.

Results: The early PVRs were 0.78 ± 0.10, 0.87 ± 0.06, and 0.93 ± 0.06 in the first 3 months after osteotomy, respectively. Moreover, the PVR in juvenile was significantly higher than that in adults in the first 3 months after osteotomy (0.80 ± 0.09 vs. 0.74 ± 0.10; p = 0.008), (0.89 ± 0.06 vs. 0.83 ± 0.06; p = 0.018), and (0.94 ± 0.05 vs. 0.87 ± 0.05; p = 0.003). In addition, the PVR in males was significantly higher than that in females in the first month after osteotomy (0.80 ± 0.09 vs. 0.76 ± 0.10; p = 0.015), and the PVR in femur site was significantly higher than that in the tibia site in the second and third months after osteotomy (0.88 ± 0.07 vs. 0.87 ± 0.06; p = 0.015) and (0.93 ± 0.06 vs. 0.92 ± 0.06, p = 0.037). However, the BMI and involvement of the internal fixator during the consolidation period seem to not influence the early PVR of regenerated callus during DO. Interestingly, the early PVR seems to be moderately inversely associated with HI (mean = 44.98 ± 49.44, r = -0.211, and p = 0.029) and LI (mean = 0.78 ± 0.77, r = -0.210, and p = 0.029), respectively.

Conclusion: The early PVR is gradually increasing in the first 3 months after osteotomy, which may be significantly influenced by chronological age, sex, and the lengthening site. Moreover, the early PVR of callus may reflect the potential clinical outcome for DO. Our results may be beneficial to the clinical management of the subjects with bone lengthening.
Thermo- and Light-Responsive Polymer-Coated Magnetic Nanoparticles as Potential Drug Carriers
Authors: Cui Guihua , Wang Hao , Long Shengsen , Zhang Tianshuo , Guo Xiaoyu , Chen Shuiying , Kakuchi Toyoji , Duan Qian , Zhao Donghai
Published: July 2022

A series of thermo- and light-responsive copolymers of poly (N-isopropylacrylamide) (PNIPAM) and 6-[4-(4-methoxy phenyl azo)-phenoxyl-hexyl methacrylate) (AzoMA) (PNIPAM-b-PAzoMA) were synthesized via reversible addition–fragmentation chain transfer (RAFT) radical polymerization. The resulting copolymers had a narrow molecular weight distribution range of 1.06–1.24, in which Mn changed regularly with the monomer concentration. Subsequently, the diblock copolymers were successfully modified on the surface of iron oxide nanoparticles through the interaction between the chemical bonds to prepare Fe3O4@(PNIPAM-b-PAzoMA) nanoparticles. The size of fabricated nanoparticles with excellent thermo-sensitivity and photo-sensitivity was controlled at about 40–50 nm. Cell viability assays suggested that the nanoparticles showed no significant cytotoxicity and potential drug delivery in the tumor microenvironment.
Impaired Cell Cycle Progression and Self-Renewal of Fetal Neural Stem and Progenitor Cells in a Murine Model of Intrauterine Growth Restriction
Authors: Chou Fu-Sheng , Chen Chu-Yen , Lee An-Chun , Wang Pei-Shan
Published: July 2022

Individuals with intrauterine growth restriction (IUGR) are at an increased risk for neurodevelopmental impairment. Fetal cortical neurogenesis is a time-sensitive process in which fetal neural stem cells (NSCs) follow a distinct pattern of layer-specific neuron generation to populate the cerebral cortex. Here, we used a murine maternal hypoxia-induced IUGR model to study the impact of IUGR on fetal NSC development. In this model, timed-pregnant mice were exposed to hypoxia during the active stage of neurogenesis, followed by fetal brain collection and analysis. In the IUGR fetal brains, we found a significant reduction in cerebral cortical thickness accompanied by decreases in layer-specific neurons. Using EdU labeling, we demonstrated that cell cycle progression of fetal NSCs was delayed, primarily observed in the G2/M phase during inward interkinetic nuclear migration. Following relief from maternal hypoxia exposure, the remaining fetal NSCs re-established their neurogenic ability and resumed production of layer-specific neurons. Surprisingly, the newly generated neurons matched their control counterparts in layer-specific marker expression, suggesting preservation of the fetal NSC temporal identity despite IUGR effects. As expected, the absolute number of neurons generated in the IUGR group remained lower compared to that in the control group due to a reduced fetal NSC pool size as a result of cell cycle defect. Transcriptome analysis identified genes related to energy expenditure and G2/M cell cycle progression being affected by maternal hypoxia-induced IUGR. Taken together, maternal hypoxia-induced IUGR is associated with a defect in cell cycle progression of fetal NSCs, and has a long-term impact on offspring cognitive development.
Advances in Blue Exciplex–Based Organic Light-Emitting Materials and Devices
Authors: Li Jie , Li Zhi , Liu Hui , Gong Heqi , Zhang Jincheng , Guo Qiang
Published: July 2022

Exciplexes possessing thermally activated delayed fluorescence (TADF) characteristics have received much attention in the fields of organic light-emitting materials and devices over the past decade. In general, an exciplex is a physical mixture between a donor (D) with hole transport properties and an acceptor (A) with electron transport characteristics, and the energy difference between the lowest excited singlet state and the lowest excited triplet state is usually fairly small in terms of the long-range charge-transfer process from D to A. In the processes of photoluminescence and electroluminescence, triplet excitons can be converted to singlet excitons through reverse intersystem crossing and then radiate photons to achieve TADF. As a consequence, triplet excitons can be effectively harvested, and the exciton utilization can be significantly enhanced. Up to now, a large number of exciplexes have been developed and applied to organic light-emitting devices. Notably most of them showed green or red emission, while blue exciplexes are relatively few owing to the spectrum characteristics of the large red-shift and broadened emission. In this study, the latest progress of blue exciplex–based organic light-emitting materials and devices is briefly reviewed, and future research is prospected.
The Potential Strategies of ZnIn2S4-Based Photocatalysts for the Enhanced Hydrogen Evolution Reaction
Authors: Tang Meng , Yin Weinan , Zhang Feiran , Liu Xia , Wang Longlu
Published: July 2022

Photocatalysis is a potential strategy to solve energy and environmental problems. The development of new sustainable photocatalysts is a current topic in the field of photocatalysis. ZnIn2S4, a visible light-responsive photocatalyst, has attracted extensive research interest in recent years. Due to its suitable band gap, strong chemical stability, durability, and easy synthesis, it is expected to become a new hot spot in the field of photocatalysis in the near future. This mini-review presents a comprehensive summary of the modulation strategies to effectively improve the photocatalytic activity of ZnIn2S4 such as morphology and structural engineering, defects engineering, doping engineering, and heterojunction engineering. This review aims to provide reference to the proof-of-concept design of highly active ZnIn2S4-based photocatalysts for the enhanced hydrogen evolution reaction.
The Long Non-Coding Antisense RNA JHDM1D-AS1 Regulates Inflammatory Responses in Human Monocytes
Authors: Malmström Erik , Khan Hina N. , Veer Cornelis van ‘t , Stunnenberg Melissa , Meijer Mariska T. , Matsumoto Hisatake , Otto Natasja A. , Geijtenbeek Teunis B. H. , de Vos Alex F. , Poll Tom van der , Scicluna Brendon P.
Published: July 2022

Monocytes are key players in innate immunity, with their ability to regulate inflammatory responses and combat invading pathogens. There is a growing body of evidence indicating that long non-coding RNA (lncRNA) participate in various cellular biological processes, including the innate immune response. The immunoregulatory properties of numerous lncRNAs discovered in monocytes remain largely unexplored. Here, by RNA sequencing, we identified a lncRNA JHDM1D-AS1, which was upregulated in blood monocytes obtained from patients with sepsis relative to healthy controls. JHDM1D-AS1 expression was induced in primary human monocytes exposed to Toll-like receptor ligands, such as lipopolysaccharide (LPS), or bacteria. The inducibility of JHDM1D-AS1 expression in monocytes depended, at least in part, on nuclear factor–κB activation. JHDM1D-AS1 knockdown experiments in human monocyte-derived macrophages revealed significantly enhanced expression of inflammatory mediators, before and after exposure to LPS, relative to control cells. Specifically, genes involved in inflammatory responses were upregulated (e.g., CXCL2, CXCL8, IL1RN, TREM1, TNF, and IL6), whereas genes involved in anti-inflammatory pathways were downregulated (e.g., SOCS1 and IL10RA). JHDM1D-AS1 overexpression in a pro-monocytic cell line revealed diminished pro-inflammatory responses subsequent to LPS challenge. Collectively, these findings identify JHDM1D-AS1 as a potential anti-inflammatory mediator induced in response to inflammatory stimuli.
Internal Climate Variability in the Present Climate and the Change in ENSO Amplitude in Future Climate Simulations
Authors: Hyun Seung-Hwon , Yeh Sang-Wook , Kirtman Ben P. , An Soon-Il
Published: July 2022

In this study, we define a metric for the intensity of internal climate variability (ICV) based on global surface temperature in the present climate and suggest that it can be used to understand the diversity of projected changes in ENSO amplitude in the future. We analyze both the 35-member Community Earth System Model Large Ensemble and the 30-members from Geophysical Fluid Dynamical Laboratory Large Ensemble from the present climate to future climate. While ENSO amplitude tends to decrease from the present climate to the end of 21st century in some ensemble member with a strong ICV during the present climate, it increases or stays the same in other ensemble members with a weak ICV. The result indicates that the intensity of ICV in the present climate in climate models may cause the difference of ENSO amplitude changes in a warmer world. Therefore, the intensity of ICV in the present climate should be cautiously examined in climate models to correctly project the ENSO amplitude changes in a changing climate.
Resilience of Avian Communities to Urbanization and Climate Change: an Integrative Review
Authors: McCloy Michael W. D. , Andringa R. Keith , Grace Jacquelyn K.
Published: July 2022

The concept of ecological resilience is widely used to assess how species and ecosystems respond to external stressors but is applied infrequently at the level of the community or to chronic, ongoing disturbances. In this review, we first discuss the concept of ecological resilience and methods for quantifying resilience in ecological studies. We then synthesize existing evidence for the resilience of avian communities to climate change and urbanization, two chronic disturbances that are driving global biodiversity loss, and conclude with recommendations for future directions. We only briefly discuss the theoretical framework behind ecological resilience and species-specific responses to these two major disturbances, because numerous reviews already exist on these topics. Current research suggests strong heterogeneity in the responses and resilience of bird communities to urbanization and climate change, although community disassembly and reassembly is high following both disturbances. To advance our understanding of community resilience to these disturbances, we recommend five areas of future study (1) the development of a standardized, comprehensive community resilience index that incorporates both adaptive capacity and measures of functional diversity, (2) measurement/modeling of both community resistance and recovery in response to disturbance, (3) multi-scale and/or multi-taxa studies that include three-way interactions between plants, animals, and climate, (4) studies that incorporate interactions between disturbances, and (5) increased understanding of interactions between ecological resilience and socio-ecological dynamics. Advancement in these areas will enhance our ability to predict and respond to the rapidly accelerating effects of climate change and urbanization.
A Bibliometric and Visualized Analysis of Uremic Cardiomyopathy From 1990 to 2021
Authors: Bao Jing-Fu , Hu Pan-Pan , She Qin-Ying , Zhang Difei , Mo Jia-Ju , Li Aiqing
Published: July 2022

Background

Uremic cardiomyopathy is commonly presented in chronic kidney disease (CKD), and it severely affects the prognosis of patients with CKD. In the past few decades, the investigation of uremic cardiomyopathy has developed rapidly. However, no report has summarized the situation of uremic cardiomyopathy research to date. This study aimed to evaluate the state of uremic cardiomyopathy research in the last 30 years and identify important topics and achievements, as well as emerging trends through bibliometric analysis.

Materials and Methods

Publications related to uremic cardiomyopathy were collected from Science Citation Index Expanded. HistCite, VOSviewer, CiteSpace, and the Bibliometrix Package were used for bibliometric analysis and visualization, including the analysis of the overall distribution of the annual publication, leading countries, and active institutions and authors, core journals, co-cited references, and keywords.

Results

A total of 2,403 studies related to uremic cardiomyopathy were obtained, and progress related to uremic cardiomyopathy was slower in past 3 years. A total of 10,077 authors from 2,697 institutions in 89 countries or regions reported investigations on uremic cardiomyopathy. The United States of America was the most productive and the most cited country. Myles Wolf, Joseph I Shapiro, and Carmine Zoccali published most articles in uremic cardiomyopathy, and journals in nephrology possessed core status in the field. Phosphate metabolism was the hotspot in uremic cardiomyopathy research in recent years, and future progress may concentrate on phosphate metabolism, endogenous natriuretic factors, and novel biomarkers.

Conclusion

The United States of America and European countries played central roles in uremic cardiomyopathy research, while Chinese scholars should be more involved in this field. Global publications on uremic cardiomyopathy have entered platform stage, and the fibroblast growth factor-23-klotho axis remained a hotspot in this field. Endogenous natriuretic factors and novel biomarkers may be potential directions in future investigations.
Combined MitraClip and Left Atrial Appendage Occlusion: Is It Still a Utopia?
Authors: Belli Martina , Zanin Federico , Macrini Massimiliano , Barone Lucy , Marchei Massimo , Muscoli Saverio , Prandi Francesca Romana , Sergi Domenico , Di Luozzo Marco , Romeo Francesco , Barillà Francesco
Published: July 2022

Atrial fibrillation (AF) is the most common cardiac arrhythmia, affecting 32 million individuals worldwide, particularly the elderly. It is the main cause of ischemic strokes. Oral anticoagulation (OAC) is the gold standard strategy for stroke prevention. Still, there is a not negligible share of patients who have contraindications to this therapy, more frequently due to an increased risk of bleeding. AF is often associated with moderate-severe mitral regurgitation (MR), the second most frequent valvular disease in elderly patients. Data from the literature reported that more than half of patients with severe mitral regurgitation are not suitable candidates for cardiac surgery. Given the progressive aging of the population and the simultaneous increase in the number of patients with comorbidities, the advent of new therapeutic strategies, such as the combined approach of Left Atrial Appendage Occlusion (LAAO) and MitraClip procedure, is acquiring great interest. At present, the category of patients who may benefit from combined percutaneous therapies and the long-term risks and benefits might not have been identified. Despite the efforts of researchers, the correct selection of patients is a very important clinical need that has not yet been met to avoid committing human and financial resources to interventions that may be unnecessary. It is conceivable that the most modern and recent innovations in cardiovascular imaging, particularly three-dimensional echocardiography and new methods of volume imaging, could improve our ability to select patients appropriately. Since data in the literature are scarce, future studies will be needed to evaluate the efficacy and safety of combined MitraClip and LAA occlusion.
Bie-Jia-Ruan-Mai-Tang, a Chinese Medicine Formula, Inhibits Retinal Neovascularization in Diabetic Mice Through Inducing the Apoptosis of Retinal Vascular Endothelial Cells
Authors: Liu Qiu-Ping , Chen Yu-Ying , Yu Yuan-Yuan , An Pei , Xing Yi-Zhuo , Yang Hong-Xuan , Zhang Yin-Jian , Rahman Khalid , Zhang Lei , Luan Xin , Zhang Hong
Published: July 2022

Proliferative diabetic retinopathy (PDR) is one of the main complications of diabetes, mainly caused by the aberrant proliferation of retinal vascular endothelial cells and the formation of new blood vessels. Traditional Chinese medicines possess great potential in the prevention and treatment of PDR. Bie-Jia-Ruan-Mai-Tang (BJ), a Chinese medicine formula, has a good therapeutic effect on PDR clinically; however, the mechanism of action involved remains unclear. Therefore, we investigated the effect of BJ on PDR through in vitro and in vivo experiments. A diabetic mouse model with PDR was established by feeding a high-fat–high-glucose diet combined with an intraperitoneal injection of streptozotocin (STZ), while high-glucose-exposed human retinal capillary endothelial cells (HRCECs) were employed to mimic PDR in vitro. The in vivo experiments indicated that BJ inhibited the formation of acellular capillaries, decreased the expression of VEGF, and increased the level of ZO-1 in diabetic mice retina. In vitro experiments showed that high glucose significantly promoted cell viability and proliferation. However, BJ inhibited cell proliferation by cycle arrest in the S phase, thus leading to apoptosis; it also increased the production of ROS, decreased the mitochondrial membrane potential, reduced the ATP production, and also reduced the expressions of p-PI3K, p-AKT, and Bcl-xL, but increased the expressions of Bax and p-NF-κB. These results suggest that BJ induces the apoptosis of HRCECs exposed to high glucose through activating the mitochondrial death pathway by decreasing the PI3K/AKT signaling and increasing the NF-κB signaling to inhibit the formation of acellular capillaries in the retina, thus impeding the development of PDR.
Comparison of Scalar Magnetic Field Data of China Seismo-Electromagnetic Satellite and Swarm Bravo Satellite
Authors: Jianing Zhang , Bingjun Cheng , Yuqi Tong , Yuanqing Miao , Bin Zhou , Andreas Pollinger , Xinghong Zhu , Yanyan Yang , Xiaochen Gou , Yiteng Zhang , Jindong Wang , Lei Li , Werner Magnes , Roland Lammegger , Zhima Zeren , Xuhui Shen
Published: July 2022

Based on the in-orbit magnetic field data of the China Seismo-Electromagnetic Satellite (CSES) and Swarm satellites, some research studies on the data consistency cross comparison were carried out. The condition applied is that two satellites pass by in a relatively short period of time and through the spatial location at a relatively close range, and different spatial-temporal scale standards were set, combined with the Kp index to screen for geomagnetic quiet periods. Then, with the help of the CHAOS model, indirect analysis was realized. Furthermore, the difference between the in-orbit data and model value was visualized, and the phenomenon and possible reason for data variation with time and geomagnetic latitude variation were analyzed. These analysis results are displayed in this study, which may evaluate the reliability of the satellite magnetic field detection data and the consistency of multiple satellite detection results and provide a methodological reference for carrying out similar evaluation and analysis subsequently.
Altered Expressions of Transfer RNA-Derived Small RNAs and microRNAs in the Vitreous Humor of Proliferative Diabetic Retinopathy
Authors: Yang Yan , Yue Wenyun , Wang Nan , Wang Zicong , Li Bingyan , Zeng Jun , Yoshida Shigeo , Ding Chun , Zhou Yedi
Published: July 2022

Purpose

We sought to reveal the expression profiles of transfer RNA-derived small RNAs (tsRNAs) and microRNAs (miRNAs) in the vitreous humor of patients with proliferative diabetic retinopathy (PDR).

Methods

Vitreous humor samples were obtained from PDR patients and a control group for this study. Sequencing of small RNAs was conducted to assess the expression profiles of tsRNAs and miRNAs in both groups, which was followed by validation using reverse transcription-quantitative real-time polymerase chain reaction (RT-qPCR). Bioinformatics analyses were conducted to predict the target genes and their potential biological functions and signaling pathways.

Results

A total of 37 tsRNAs and 70 miRNAs with significant differences were screened out from the vitreous humor samples of PDR patients compared to controls. Following validation by RT-qPCR, the target genes of the validated tsRNAs and miRNAs were predicted, and Gene Ontology analysis indicated that the target genes of the tsRNAs were most enriched in the cellular macromolecule metabolic process, cytoplasm, and ion-binding, while those of the miRNAs were most abundant in the regulation of major metabolic process, cytoplasm, and protein-binding. In addition, Kyoto Encyclopedia of Genes and Genomes pathway analysis showed that the target genes of said tsRNAs and miRNAs were most enriched in the adenosine monophosphate-activated protein kinase signaling pathway and Th17 cell differentiation, respectively.

Conclusions

The present study identified altered tsRNAs and miRNAs in vitreous humor samples of PDR patients, which may play important roles in the pathogenesis of PDR and could be considered potential therapeutic targets in the treatment of PDR.
Reference Data of Phase Angle Using Bioelectrical Impedance Analysis in Overweight and Obese Chinese
Authors: Fu Luo , Ren Zhengyun , Liu Xiaoxiao , Wu Nianwei , Zhao Kang , Luo Guangping , Yang Huawu , Zhang Yuanchuan , Yan Tong , Liu Yanjun , Zhang Tongtong
Published: July 2022

Introduction

Phase angle (PhA) is a ratio of reactance and resistance {arctangent (reactance (Xc)/resistance (R)) × (180°/π)}, which can be obtained by bioelectrical impedance analysis (BIA). PhA indicates cellular health and integrity, and it is also considered as a prognostic tool in medical disorders and an indicator of nutritional status (especially of muscle quality) in patients with obesity. However, PhA has limited usefulness in clinical practice because of a lackness of reference values for Chinese overweight and obese populations. The main aim of this study was to show PhA reference data in different age and BMI groups by sex. In addition, we also study the association of age, sex, and BMI on PhA.

Methods

A total of 1729 overweight and obese participants were included in this study. PhA and body composition were measured using segmental multifrequency BIA. Differences in mean values for variables were tested by one-way analysis of variance. Multiple regression analysis was used to assess the associations of PhA with age, sex and BMI.

Results

Multiple regression analysis showed that age, sex and BMI were significant (P < 0.05) independent influence factors of PhA in Chinese overweight and obese adults when age and BMI were continues variables. The mean PhA value for all participants was 5.5°. Mean BMI, age, weight, height and 50kHz-PhA were significantly higher (P < 0.001) in male participants than female ones. In age groups and BMI groups, mean 50kHz-PhA was significantly higher (P < 0.005) in male participants than female ones. When age groups and BMI groups were categorical variables, multiple regression analysis showed that different age groups (46–55 years and ≥ 56 years) had a significantly lower (P < 0.005) PhA as compared with the baseline group (18-25 years) and different BMI groups (≥ 28 kg/m2) had a significantly higher (P < 0.05) PhA as compared with the baseline group (24–27.9 kg/m2).

Conclusion

PhA differed according to age, sex and BMI. Reference data in this study can be taken into consideration when deriving the reference values for overweight and obese Chinese populations.
Nacre-Like Reduced Graphene Oxide/Silver Nanowire Paper With Reinforced Chemical and Electrical Stability for Fast Electrical Heating System
Authors: Zou Xiuxiu , Shen Kuizhong , Lin Yan , Liang Fangmin , Sun Enhui , Wu Yiqiang , Fang Guigan
Published: July 2022

Silver nanowire (AgNW) has excellent thermal conductivity, which is an ideal material for fabricating flexible electrical heating materials. However, the poor stability of AgNWs is far from meeting the requirements for the practical application of electrical heating materials. Herein, by imitating the layered structure of nacre, the reduced graphene oxide (rGO)/AgNWs paper with a nacre-like structure was successfully prepared using a simple gravity-induced deposition approach. The obtained rGO/AgNWs paper showed excellent electrical conductivity (19.61 Ω/sq) and good pattern adjustability at the rGO to AgNWs ratio of 1:1. More importantly, the rGO/AgNWs paper exhibited high resistance to oxygen and water vapor, thus realizing long-term stability and reliability. Moreover, the design of a nacre-like structure could improve the thermal management performances of rGO/AgNWs paper, making it achieve a high Joule heating temperature (∼215.83°C) at low supplied voltages (3 V), the rapid response time (∼12 s) and long-term heating stability. These results indicate that the prepared rGO/AgNWs paper promises to be an electrical heating component with high chemical stability for thermal management electric materials.
On the Method of Design Drift-Ice Concentration and Floe Area for New-Energy Structures in Ice-Infested Nearshore Areas of the Bohai Sea, China
Authors: Li Zhijun , Xiu Yuanren , Wang Qingkai , Li Ge , Lu Peng , Zhong Shan , Chen Xue
Published: July 2022

To provide basic drift-ice parameters for new-energy structures in ice-infested nearshore waters, an estimation method of the design drift-ice concentration and floe area was established. A total of 700 satellite images in winters from 2010 to 2021 were used to obtain the drift-ice concentration and floe area from 26 sites in the Bohai Sea. The floe area with 90% cumulative probability was selected as the characteristic floe area in each satellite image. Furthermore, the water temperature threshold ranging from −1.6 °C to −0.5 °C was adopted by considering the drift-ice freezing/melting states because of different salinity values in nearshore waters. The upper limit values of the ice concentration and characteristic floe area at the lowest water temperature of −1.6 °C were finally used as the design drift-ice indexes. The maximum design ice concentrations (floe area) in the Liaodong Bay, Bohai Bay, and Laizhou Bay were 96% (0.43 km2), 91% (0.39 km2), and 87% (0.29 km2), respectively. The design ice concentration at the bay bottom was higher than that near the mouth. The design floe area in the Liaodong Bay and Bohai Bay increased with latitudes, but the trend was opposite in the Laizhou Bay. The method developed in the current study has universal applicability, which can be extended to other ice-cover waters and specific structure designs by adjusting the cumulative probability threshold and the water temperature threshold.
Chile and its Potential Role Among the Most Affordable Green Hydrogen Producers in the World
Authors: Acosta Kevin , Salazar Iván , Saldaña Manuel , Ramos Jahir , Navarra Alessandro , Toro Norman
Published: July 2022

As result of the adverse effects caused by climate change, the nations have decided to accelerate the transition of the energy matrix through the use of non-conventional sources free of polluting emissions. One of these alternatives is green hydrogen. In this context, Chile stands out for the exceptional climate that makes it a country with a lot of renewable resources. Such availability of resources gives the nation clear advantages for hydrogen production, strong gusts of wind throughout the country, the most increased solar radiation in the world, lower cost of production of electrical supplies, among others. Due to this, the nation would be between the lowest estimated cost for hydrogen production, i.e., 1.5 USD/kg H2 approximately, scenario that would place it as one of the cheapest green hydrogen producer in the world.
Boosted Regression Tree Algorithm for the Reconstruction of GRACE-Based Terrestrial Water Storage Anomalies in the Yangtze River Basin
Authors: Dannouf Ramia , Yong Bin , Ndehedehe Christopher E. , Correa Fabio M. , Ferreira Vagner
Published: July 2022

The terrestrial water storage anomaly (TWSA) from the previous Gravity Recovery and Climate Experiment (GRACE) covers a relatively short period (15 years) with several missing periods. This study explores the boosted regression trees (BRT) and the artificial neural network (ANN) to reconstruct the TWSA series between 1982 and 2014 over the Yangtze River basin (YRB). Both algorithms are trained with several hydro-climatic variables (e.g., precipitation, soil moisture, and temperature) and climate indices for the YRB. The results from this study show that the BRT is capable of reconstructing TWSA and shows Nash–Sutcliffe efficiency (NSE) of 0.89 and a root-mean-square error (RMSE) of 18.94 mm during the test stage, outperforming ANN in about 2.3% and 7.4%, respectively. As a step further, the reliability of this technique in reconstructing TWSA beyond the GRACE era was also evaluated. Hence, a closed-loop simulation using the artificial TWSA series over 1982–2014 under the same scenarios for the actual GRACE data shows that BRT can predict TWSA (NSE of 0.92 and RMSE of 6.93 mm). Again, the BRT outperformed the ANN by approximately 1.1% and 5.3%, respectively. This study provides a new perspective for reconstructing and filling the gaps in the GRACE–TWSA series over data-scarce regions, which is desired for hydrological drought characterization and environmental studies. BRT offers such an opportunity for the GRACE Follow-On mission to predict 11 months of missing TWSA data by relying on a limited number of predictive variables, hence being adjudged to be more economical than the ANN.
Disentangling Forest Dynamics for Litter Biomass Production in a Biosphere Reserve in Central India
Authors: Thakur Tarun Kumar , Eripogu Kiran Kumar , Thakur Anita , Kumar Amit , Bakshi Sanjeev , Swamy S. L. , Bijalwan Arvind , Kumar Munesh
Published: July 2022

Investments in energy sources are scaling up across India to improve climate security and further mitigate future climate change. Forest biomass and litterfall pattern play an important role in the sustainable management of forests and the efficient utilization of resources. This study investigates the seasonal litterfall biomass pattern for five consecutive years (2015–2019) in four different vegetation types in Central India (AABR) using the litter traps method on the forest floor. An ANOVA model was adopted to infer the effects of forest types, litter types, and seasonality on litterfall production. The estimated mean litterfall of the dry tropical forest in Central India was recorded as 4.19 ± 0.305 Mg/ha/y where teak plantations contribute higher values compared to other studied vegetation types. A positive correlation was observed between the litterfall and nutrient storage with soil-adjusted vegetation index and other vegetation indices. The findings of litterfall pattern and turnover rate of nutrients indicated that the vegetation types of AABR have huge potential for carbon sequestration and help to achieve the Conference of the Parties (COP-26) goal of reducing regional and/or global climate change.
Shape of Evasive Prey Can Be an Important Cue That Triggers Learning in Avian Predators
Authors: Linke Daniel , Elias Marianne , Klečková Irena , Mappes Johanna , Matos-Maraví Pável
Published: July 2022

Advertising escape ability could reduce predatory attacks. However, the effectiveness of certain phenotypic cues (e.g., color, shape, and size) in signaling evasiveness is still unknown. Understanding the role of such signals in driving predator learning is important to infer the evolutionary mechanisms leading to convergent evasiveness signals among prey species (i.e., evasive mimicry). We aim to understand the role of the color pattern (white patches on dark background) and morphology (extended butterfly hindwings) in driving learning and avoidance of escaping prey by surrogate avian predators, the European blue tit. These cues are common in butterflies and have been suspected to advertise escape ability in nature. We use dummy butterflies harboring shape and color patterns commonly found in skippers (family Hesperiidae). The prey models displayed the studied phenotypical cues (hindwing tails and white bands) in factorial combinations, and we tested whether those cues were learned as evasive signals and were generalised to different phenotypes. Our results suggest that hindwing tails and white bands can be associated with prey evasiveness. In addition, wild blue tits might learn and avoid attacking prey models bearing the studied phenotypic cues. Although blue tits seem to have an initial preference for the phenotype consisting of white patches and hindwing tails, the probability of attacking it was substantially reduced once the cues were associated with escaping ability. This suggests that the same morphological cues might be interchangeable as preference/avoidance signals. Further investigation of the salience of hindwing tails vs. white bands as cues for escaping ability, revealed that predators can associate both color pattern and shape to the difficulty of capture, and possibly generalize their aversion to other prey harboring those cues. More studies with larger sample sizes are needed to confirm this trend. Altogether, our results highlight the hitherto overlooked role of shape (butterfly hindwing tails) for signaling prey unprofitability.