bluuebunny/crossref_metadata_2025 huggingface dataset:
Aggression, Impulsivity and Suicidal Behavior in Depressive Disorders: A Comparison Study between New York City (US), Madrid (Spain) and Florence (Italy)
Authors: Lopez-Morinigo Javier-David , Boldrini Maura , Ricca Valdo , Oquendo Maria A. , Baca-García Enrique
Published: July 2021

The association of aggression and impulsivity with suicidal behavior (SB) in depression may vary across countries. This study aimed (i) to compare aggression and impulsivity levels, measured with the Brown-Goodwin Scale (BGS) and the Barratt Impulsivity Scale (BIS), respectively, between New York City (NYC) (US), Madrid (Spain) and Florence (Italy) (ANOVA); and (ii) to investigate between-site differences in the association of aggression and impulsivity with previous SB (binary logistic regression). Aggression scores were higher in NYC, followed by Florence and Madrid. Impulsivity levels were higher in Florence than in Madrid or NYC. Aggression and impulsivity scores were higher in suicide attempters than in non-attempters in NYC and in Madrid. SB was associated with aggression in NYC (OR 1.12, 95% CI 1.07–1.16; p < 0.001) and in Florence (OR 1.11, 95% CI 1.01–1.22; p = 0.032). Impulsivity was linked with SB in NYC (OR 1.01, 95% CI 1.00–1.02; p < 0.001) and in Madrid (OR 1.03, 95% CI 1.02–1.05; p < 0.001). The higher suicide rates in NYC, compared to Madrid or Florence, may be, in part, explained by these cross-cultural differences in the contribution of aggression-impulsivity to SB, which should be considered by future research on SB prevention.
Techno-Economic Assessment of Offshore Wind Energy in the Philippines
Authors: Maandal Gerard Lorenz D. , Tamayao-Kieke Mili-Ann M. , Danao Louis Angelo M.
Published: July 2021

The technical and economic assessments for emerging renewable energy technologies, specifically offshore wind energy, is critical for their improvement and deployment. These assessments serve as one of the main bases for the construction of offshore wind farms, which would be beneficial to the countries gearing toward a sustainable future such as the Philippines. This study presents the technical and economic viability of offshore wind farms in the Philippines. The analysis was divided into four phases, namely, application of exclusion criteria, technical analysis, economic assessment, and sensitivity analysis. Arc GIS 10.5 was used to spatially visualize the results of the study. Exclusion criteria were applied to narrow down the potential siting for offshore wind farms, namely, active submerged cables, local ferry routes, marine protected areas, reefs, oil and gas extraction areas, bathymetry, distance to grid, typhoons, and earthquakes. In the technical analysis, the turbines SWT-3.6-120 and 6.2 M126 Senvion were considered. The offshore wind speed data were extrapolated from 80 m to 90 m and 95 m using power law. The wind power density, wind power, and annual energy production were calculated from the extrapolated wind speed. Areas in the Philippines with a capacity factor greater than 30% and performance greater than 10% were considered technically viable. The economic assessment considered the historical data of constructed offshore wind farms from 2008 to 2018. Multiple linear regression was done to model the cost associated with the construction of offshore wind farms, namely, turbine, foundation, electrical, and operation and maintenance costs (i.e., investment cost). Finally, the levelized cost of electricity and break-even selling price were calculated to check the economic viability of the offshore wind farms. Sensitivity analysis was done to investigate how LCOE and price of electricity are sensitive to the discount rate, capacity factor, investment cost, useful life, mean wind speed, and shape parameter. Upon application of exclusion criteria, several sites were determined to be viable with the North of Cagayan having the highest capacity factor. The calculated capacity factor ranges from ~42% to ~50% for SWT-3.6-120 and ~38.56% to ~48% for 6.2M126 turbines. The final regression model with investment cost as the dependent variable included the minimum sea depth and the plant capacity as the predictor variables. The regression model had an adjusted R2 of 90.43%. The regression model was validated with existing offshore wind farms with a mean absolute percentage error of 11.33%. The LCOE calculated for a 25.0372 km2 offshore area ranges from USD 157.66/MWh and USD 154.1/MWh. The breakeven electricity price for an offshore wind farm in the Philippines ranges from PHP 8.028/kWh to PHP 8.306/kWh.
Special Issue “Absorbable Metals for Biomedical Applications”
Authors: Hermawan Hendra , Razavi Mehdi
Published: July 2021

Current temporary metal implants made from titanium or stainless steel are not absorbable [...]
Soldering of Electronics Components on 3D-Printed Conductive Substrates
Authors: Podsiadły Bartłomiej , Skalski Andrzej , Słoma Marcin
Published: July 2021

Rapid development of additive manufacturing and new composites materials with unique properties are promising tools for fabricating structural electronics. However, according to the typical maximum resolution of additive manufacturing methods, there is no possibility to fabricate all electrical components with these techniques. One way to produce complex structural electronic circuits is to merge 3D-printed elements with standard electronic components. Here, different soldering and surface preparation methods before soldering are tested to find the optimal method for soldering typical electronic components on conductive, 3D-printed, composite substrates. To determine the optimal soldering condition, the contact angles of solder joints fabricated in different conditions were measured. Additionally, the mechanical strength of the joints was measured using the shear force test. The research shows a possibility of fabricating strong, conductive solder joints on composites substrates prepared by additive manufacturing. The results show that mechanical cleaning and using additional flux on the composite substrates are necessary to obtain high-quality solder joints. The most repeatable joints with the highest shear strength values were obtained using reflow soldering together with low-temperature SnBiAg solder alloy. A fabricated demonstrator is a sample of the successful merging of 3D-printed structural electronics with standard electronic components.
Inspection—Corruption Game of Illegal Logging and Other Violations: Generalized Evolutionary Approach
Authors: Kolokoltsov Vassili N.
Published: July 2021

Games of inspection and corruption are well developed in the game-theoretic literature. However, there are only a few publications that approach these problems from the evolutionary point of view. In previous papers of this author, a generalization of the replicator dynamics of the evolutionary game theory was suggested for inspection modeling, namely the pressure and resistance framework, where a large pool of small players plays against a distinguished major player and evolves according to certain myopic rules. In this paper, we develop this approach further in a setting of the two-level hierarchy, where a local inspector can be corrupted and is further controlled by the higher authority (thus combining the modeling of inspection and corruption in a unifying setting). Mathematical novelty arising in this investigation involves the analysis of the generalized replicator dynamics (or kinetic equation) with switching, which occurs on the “efficient frontier of corruption”. We try to avoid parameters that are difficult to observe or measure, leading to some clear practical consequences. We prove a result that can be called the “principle of quadratic fines”: We show that if the fine for violations (both for criminal businesses and corrupted inspectors) is proportional to the level of violations, the stable rest points of the dynamics support the maximal possible level of both corruption and violation. The situation changes if a convex fine is introduced. In particular, starting from the quadratic growth of the fine function, one can effectively control the level of violations. Concrete settings that we have in mind are illegal logging, the sales of products with substandard quality, and tax evasion.
The Marine-Derived Natural Product Epiloliolide Isolated from Sargassum horneri Regulates NLRP3 via PKA/CREB, Promoting Proliferation and Anti-Inflammatory Effects of Human Periodontal Ligament Cells
Authors: Kim Eun-Nam , Nabende Woguti Yvonne , Jeong Hyeyoon , Hahn Dongyup , Jeong Gil-Saeng
Published: July 2021

Currently, periodontitis treatment relies on surgical operations, anti-inflammatory agents, or antibiotics. However, these treatments cause pain and side effects, resulting in a poor prognosis. Therefore, in this study, we evaluated the impact of the compound epiloliolide isolated from Sargassum horneri on the recovery of inflammatory inhibitors and loss of periodontal ligaments, which are essential treatment strategies for periodontitis. Here, human periodontal ligament cells stimulated with PG-LPS were treated with the compound epiloliolide, isolated from S. horneri. In the results of this study, epiloliolide proved the anti-inflammatory effect, cell proliferation capacity, and differentiation potential of periodontal ligament cells into osteoblasts, through the regulation of the PKA/CREB signaling pathway. Epiloliolide effectively increased the proliferation and migration of human periodontal ligament cells without cytotoxicity and suppressed the protein expression of proinflammatory mediators and cytokines, such as iNOS, COX-2, TNF-α, IL-6, and IL-1β, by downregulating NLRP3 activated by PG-LPS. Epiloliolide also upregulated the phosphorylation of PKA/CREB proteins, which play an important role in cell growth and proliferation. It was confirmed that the anti-inflammatory effect in PG-LPS-stimulated large cells was due to the regulation of PKA/CREB signaling. We suggest that epiloliolide could serve as a potential novel therapeutic agent for periodontitis by inhibiting inflammation and restoring the loss of periodontal tissue.
How Do the Abdominal Muscles Change during Hypopressive Exercise?
Authors: Da Cuña-Carrera Iria , Alonso-Calvete Alejandra , Soto-González Mercedes , Lantarón-Caeiro Eva M.
Published: July 2021

Background and objective: Prior studies have reported an activation of abdominal muscles during hypopressive exercises in women with pelvic floor disfunction. However, no previous research analyzed the effects of hypopressive exercise on abdominal muscles in healthy populations to understand the normal biomechanics of this area. The aim of this study was to examine the thickness of abdominal muscles at rest and during hypopressive exercise in supine and standing positions with ultrasound imaging in healthy adults. Methods: A cross-sectional study was carried out in 99 healthy university students. The thickness of the abdominal muscles at rest and during hypopressive exercise was assessed with ultrasound imaging in supine and standing positions. Results: During hypopressive exercise, there was a significant increase in the muscle thickness of transversus abdominis (p < 0.001) and internal oblique (p < 0.001) in supine and standing positions. External oblique only increased its thickness significantly in the standing position (p < 0.001) and rectus abdominis did not change during the hypopressive exercise in any position (p > 0.05). In conclusion, hypopressive exercises seem to increase the thickness of the deepest and most stabilized muscles such as transversus abdominis and internal oblique. Conclusions: These findings should be considered for future interventions with hypopressive exercises in healthy subjects.
MnO2@Reduced Graphene Oxide Nanocomposite-Based Electrochemical Sensor for the Simultaneous Determination of Trace Cd(II), Zn(II) and Cu(II) in Water Samples
Authors: Mnyipika Siyamthanda Hope , Munonde Tshimangadzo Saddam , Nomngongo Philiswa Nosizo
Published: July 2021

The rapid detection of trace metals is one of the most important aspect in achieving environmental monitoring and protection. Electrochemical sensors remain a key solution for rapid detection of heavy metals in environmental water matrices. This paper reports the fabrication of an electrochemical sensor obtained by the simultaneous electrodeposition of MnO2 nanoparticles and RGO nanosheets on the surface of a glassy carbon electrode. The successful electrodeposition was confirmed by the enhanced current response on the cyclic voltammograms. The XRD, HR-SEM/EDX, TEM, FTIR, and BET characterization confirmed the successful synthesis of MnO2 nanoparticles, RGO nanosheets, and MnO2@RGO nanocomposite. The electrochemical studies results revealed that MnO2@RGO@GCE nanocomposite considerably improved the current response on the detection of Zn(II), Cd(II) and Cu(II) ions in surface water. These remarkable improvements were due to the interaction between MnO2 nanomaterials and RGO nanosheets. Moreover, the modified sensor electrode portrayed high sensitivity, reproducibility, and stability on the simultaneous determination of Zn(II), Cd(II), and Cu(II) ions. The detection limits of (S/N = 3) ranged from 0.002–0.015 μg L−1 for the simultaneous detection of Zn(II), Cd(II), and Cu(II) ions. The results show that MnO2@RGO nanocomposite can be successfully used for the early detection of heavy metals with higher sensitivity in water sample analysis.
Electron Beam Powder Bed Fusion of γ-Titanium Aluminide: Effect of Processing Parameters on Part Density, Surface Characteristics, and Aluminum Content
Authors: Moritz Juliane , Teschke Mirko , Marquardt Axel , Stepien Lukas , López Elena , Brückner Frank , Macias Barrientos Marina , Walther Frank , Leyens Christoph
Published: July 2021

Gamma titanium aluminides are very interesting for their use in high-performance applications such as aircraft engines due to their low density, high stiffness and favorable high-temperature properties. However, the pronounced brittleness of these intermetallic alloys is a major challenge for their processing through conventional fabrication methods. Additive manufacturing by means of electron beam powder bed fusion (EB-PBF) significantly improves the processability of titanium aluminides due to the high preheating temperatures and facilitates complex components. The objective of this study was to determine a suitable processing window for EB-PBF of the TNM-B1 alloy (Ti-43.5Al-4Nb-1Mo-0.1B), using an increased aluminum content in the powder raw material to compensate for evaporation losses during the process. Design of experiments was used to evaluate the effect of beam current, scan speed, focus offset, line offset and layer thickness on porosity. Top surface roughness was assessed through laser scanning confocal microscopy. Scanning electron microscopy, electron backscatter diffraction (EBSD) and energy-dispersive X-ray spectroscopy (EDX) were used for microstructural investigation and to analyze aluminum loss depending on the volumetric energy density used in EB-PBF. An optimized process parameter set for achieving part densities of 99.9% and smooth top surfaces was derived. The results regarding microstructures and aluminum evaporation suggest a solidification via the β-phase.
Influences of Initial Surface Conditions on Response Characteristics of Amorphous Silicon Films to Nanosecond Laser Irradiation
Authors: Ren Yingming , Zhang Zhiyu
Published: July 2021

Although laser-produced micro-/nano-structures have been extensively studied, the effects of the initial surface conditions on the formed micro-/nano-structures have rarely been investigated. In this study, through nanosecond pulsed laser irradiation of unpolished and polished amorphous silicon films, entirely different surface characteristics were observed. The effects of laser irradiation parameters, such as repetition frequency, beam overlap ratio, and scanning velocity, on the surface characteristics were investigated, followed by the characterization of surface roughness, energy-dispersive X-ray spectroscopy, and Raman spectroscopy of the irradiated surfaces. For the unpolished surface, novel micro-protrusions were generated after laser irradiation, whereas no such micro-protrusions were formed on the polished surface. The experimental results indicated that the height of the micro-protrusions could be tuned using laser irradiation parameters and that laser irradiation promoted the crystallization of the amorphous silicon film. Moreover, the formation mechanism of the micro-protrusions was linked to fluctuations of the solid–liquid interface caused by continuous laser pulse shocks at higher repetition frequencies. The findings of this study suggest important correlations between the initial surface conditions and micro-/nano-structure formation, which may enhance our fundamental understanding of the formation of micro-/nano-structures.
A State-of-the-Art Review on Core–Shell Pigments Nanostructure Preparation and Test Methods
Authors: Shah Kwok Wei , Huseien Ghasan Fahim , Kua Harn Wei
Published: July 2021

Uses of novel technologies for improving the durability and lifespan of the construction materials have emerged as viable solutions toward the sustainable future wherein the coating industry plays a significant role in economy growth and better livelihoods. Thus, the continual innovation of various technologies to introduce diverse market products has become indispensable. Properties of materials like color stability under UV, elevated temperatures and aggressive environments, and skid and abrasion resistance are the main challenges faced by commercial coating materials, leading to more demand of natural materials as sustainable agents. Lately, nanostructured core–shell pigments with unique compositions have widely been utilized in composite materials to enhance their properties. Core–shell particles exhibit smart properties and have immense benefits when combined with building materials. Based on these facts, we comprehensively overviewed the state-of-the-art research of core–shell nanomaterials in terms of their preparation and performance evaluation methods, as well as feasible applications. The first part of this article discusses effective shell materials, including most common silica and titanium oxides. In addition, nanotechnology enabling the production and patterning of low-dimensional materials for widespread applications is emphasized. The second part deals with various potential core materials used to achieve core–shell nanostructures. The third part of this paper highlights some interesting mechanisms of core–shell structures in the modified systems that display high stability, durability, efficiency, and eco-friendliness. Finally, different applications of these core–shell nanostructures are underscored together with their test methods to evaluate their performances.
High-Speed Imaging of Second-Harmonic Generation in MoS2 Bilayer under Femtosecond Laser Ablation
Authors: Kim Young Chul , Yoo Hoseong , Nguyen Van Tu , Lee Soonil , Park Ji-Yong , Ahn Yeong Hwan
Published: July 2021

We report an in situ characterization of transition-metal dichalcogenide (TMD) monolayers and twisted bilayers using a high-speed second-harmonic generation (SHG) imaging technique. High-frequency laser modulation and galvano scanning in the SHG imaging enabled a rapid identification of the crystallinity in the TMD, including the orientation and homogeneity with a speed of 1 frame/s. For a twisted bilayer MoS2, we studied the SHG peak intensity and angles as a function of the twist angle under a strong interlayer coupling. In addition, rapid SHG imaging can be used to visualize laser-induced ablation of monolayer and bilayer MoS2 in situ under illumination by a strong femtosecond laser. Importantly, we observed a characteristic threshold behavior; the ablation process occurred for a very short time duration once the preheating condition was reached. We investigated the laser thinning of the bilayer MoS2 with different twist angles. When the twist angle was 0°, the SHG decreased by approximately one-fourth of the initial intensity when one layer was removed. Conversely, when the twist angle was approximately 60° (the SHG intensity was suppressed), the SHG increased abruptly close to that of the nearby monolayer when one layer was removed. Precise layer-by-layer control was possible because of the unique threshold behavior of the laser-induced ablation.
Magnetism of Nanoparticles: Effect of the Organic Coating
Authors: Abdolrahimi Maryam , Vasilakaki Marianna , Slimani Sawssen , Ntallis Nikolaos , Varvaro Gaspare , Laureti Sara , Meneghini Carlo , Trohidou Kalliopi N. , Fiorani Dino , Peddis Davide
Published: July 2021

The design of novel multifunctional materials based on nanoparticles requires tuning of their magnetic properties, which are strongly dependent on the surface structure. The organic coating represents a unique tool to significantly modify the surface structure trough the bonds between the ligands of the organic molecule and the surface metal atoms. This work presents a critical overview of the effects of the organic coating on the magnetic properties of nanoparticles trough a selection of papers focused on different approaches to control the surface structure and the morphology of nanoparticles’ assemblies.
Recent Progress in Nanotechnology for COVID-19 Prevention, Diagnostics and Treatment
Authors: Rasmi Yousef , Saloua Kouass , Nemati Mahdieh , Choi Jane
Published: July 2021

The COVID-19 pandemic is currently an unprecedented public health threat. The rapid spread of infections has led to calls for alternative approaches to combat the virus. Nanotechnology is taking root against SARS-CoV-2 through prevention, diagnostics and treatment of infections. In light of the escalating demand for managing the pandemic, a comprehensive review that highlights the role of nanomaterials in the response to the pandemic is highly desirable. This review article comprehensively discusses the use of nanotechnology for COVID-19 based on three main categories: prevention, diagnostics and treatment. We first highlight the use of various nanomaterials including metal nanoparticles, carbon-based nanoparticles and magnetic nanoparticles for COVID-19. We critically review the benefits of nanomaterials along with their applications in personal protective equipment, vaccine development, diagnostic device fabrication and therapeutic approaches. The remaining key challenges and future directions of nanomaterials for COVID-19 are briefly discussed. This review is very informative and helpful in providing guidance for developing nanomaterial-based products to fight against COVID-19.
Phenolic Hydroxyl Groups in the Lignin Polymer Affect the Formation of Lignin Nanoparticles
Authors: Lee Jae Hoon , Kim Tae Min , Choi In-Gyu , Choi Joon Weon
Published: July 2021

Alkaline soda lignin (AL) was sequentially fractionated into six fractions of different molecular size by means of solvent extraction and their phenolic hydroxyl groups were chemoselectively methylated to determine their effect on nanoparticle formation of lignin polymers. The effect of the lignin structure on the physical properties of nanoparticles was also clarified in this study. Nanoparticles were obtained from neat alkaline soda lignin (ALNP), solvent-extracted fractions (FALNPs, i.d. 414–1214 nm), and methylated lignins (MALNPs, i.d. 516–721 nm) via the nanoprecipitation method. Specifically, the size properties of MALNPs showed a high negative correlation (R2 = 0.95) with the phenolic hydroxyl group amount. This indicates that the phenolic hydroxyl groups in lignin could be influenced on the nucleation or condensation during the nanoprecipitation process. Lignin nanoparticles exhibited high colloidal stability, and most of them also showed good in vitro cell viability. This study presents a possible way to control nanoparticle size by blocking specific functional groups and decreasing the interaction between hydroxyl groups of lignin.
Hydrotalcite-Embedded Magnetite Nanoparticles for Hyperthermia-Triggered Chemotherapy
Authors: Simeonidis Konstantinos , Kaprara Efthimia , Rivera-Gil Pilar , Xu Ruixue , Teran Francisco J. , Kokkinos Evgenios , Mitropoulos Athanassios , Maniotis Nikolaos , Balcells Lluis
Published: July 2021

A magnetic nanocomposite, consisting of Fe3O4 nanoparticles embedded into a Mg/Al layered double hydroxide (LDH) matrix, was developed for cancer multimodal therapy, based on the combination of local magnetic hyperthermia and thermally induced drug delivery. The synthesis procedure involves the sequential hydrolysis of iron salts (Fe2+, Fe3+) and Mg2+/Al3+ nitrates in a carbonate-rich mild alkaline environment followed by the loading of 5-fluorouracil, an anionic anticancer drug, in the interlayer LDH space. Magnetite nanoparticles with a diameter around 30 nm, dispersed in water, constitute the hyperthermia-active phase able to generate a specific loss of power of around 500 W/g-Fe in an alternating current (AC) magnetic field of 24 kA/m and 300 kHz as determined by AC magnetometry and calorimetric measurements. Heat transfer was found to trigger a very rapid release of drug which reached 80% of the loaded mass within 10 min exposure to the applied field. The potential of the Fe3O4/LDH nanocomposites as cancer treatment agents with minimum side-effects, owing to the exclusive presence of inorganic phases, was validated by cell internalization and toxicity assays.
Iron-Containing Oral Contraceptives and Their Effect on Hemoglobin and Biomarkers of Iron Status: A Narrative Review
Authors: Fischer Jordie A. J. , Sasai Carolina S. , Karakochuk Crystal D.
Published: July 2021

Oral contraceptive use has been associated with decreased menstrual blood losses; thus, can independently reduce the risk of anemia and iron deficiency in women. Manufacturers have recently started to include supplemental iron in the non-hormonal placebo tablets of some contraceptives. The aims of this narrative review are: (i) to describe the relationship between oral contraceptive use and both anemia and iron status in women; (ii) to describe the current formulations of iron-containing oral contraceptives (ICOC) available on the market; and (iii) to systematically review the existing literature on the effect of ICOC on biomarkers of anemia and iron status in women. We discovered 21 brands of ICOC, most commonly including 25 mg elemental iron as ferrous fumarate, for seven days, per monthly tablet package. Our search identified one randomized trial evaluating the effectiveness of ICOC use compared to two non-ICOC on increasing hemoglobin (Hb) and iron status biomarker concentrations in women; whereafter 12 months of contraception use, there were no significant differences in Hb concentration nor markers of iron status between the groups. ICOC has the potential to be a cost-effective solution to address both family planning needs and iron deficiency anemia. Yet, more rigorous trials evaluating the effectiveness of ICOC on improving markers of anemia and iron deficiency, as well as investigating the safety of its consumption among iron-replete populations, are warranted.
Intake of Fish and Marine n-3 Polyunsaturated Fatty Acids and Risk of Cardiovascular Disease Mortality: A Meta-Analysis of Prospective Cohort Studies
Authors: Jiang Lan , Wang Jinyu , Xiong Ke , Xu Lei , Zhang Bo , Ma Aiguo
Published: July 2021

Previous epidemiological studies have investigated the association of fish and marine n-3 polyunsaturated fatty acids (n-3 PUFA) consumption with cardiovascular disease (CVD) mortality risk. However, the results were inconsistent. The purpose of this meta-analysis is to quantitatively evaluate the association between marine n-3 PUFA, fish and CVD mortality risk with prospective cohort studies. A systematic search was performed on PubMed, Web of Science, Embase and MEDLINE databases from the establishment of the database to May 2021. A total of 25 cohort studies were included with 2,027,512 participants and 103,734 CVD deaths. The results indicated that the fish consumption was inversely associated with the CVD mortality risk [relevant risk (RR) = 0.91; 95% confidence intervals (CI) 0.85−0.98]. The higher marine n-3 PUFA intake was associated with the reduced risk of CVD mortality (RR = 0.87; 95% CI: 0.85–0.89). Dose-response analysis suggested that the risk of CVD mortality was decreased by 4% with an increase of 20 g of fish intake (RR = 0.96; 95% CI: 0.94–0.99) or 80 milligrams of marine n-3 PUFA intake (RR = 0.96; 95% CI: 0.94–0.98) per day. The current work provides evidence that the intake of fish and marine n-3 PUFA are inversely associated with the risk of CVD mortality.
Folic Acid Supplementation Improves Glycemic Control for Diabetes Prevention and Management: A Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials
Authors: Asbaghi Omid , Ashtary-Larky Damoon , Bagheri Reza , Moosavian Seyedeh Parisa , Olyaei Hadi Pourmirzaei , Nazarian Behzad , Rezaei Kelishadi Mahnaz , Wong Alexei , Candow Darren G. , Dutheil Frédéric , Suzuki Katsuhiko , Alavi Naeini Amirmansour
Published: July 2021

Background: There is a growing interest in the considerable benefits of dietary supplementations, such as folic acid, on the glycemic profile. We aimed to investigate the effects of folic acid supplementation on glycemic control markers in adults. Methods: Randomized controlled trials examining the effects of folic acid supplementation on glycemic control markers published up to March 2021 were detected by searching online databases, including Scopus, PubMed, Embase, and ISI web of science, using a combination of related keywords. Mean change and standard deviation (SD) of the outcome measures were used to estimate the mean difference between the intervention and control groups at follow-up. Meta-regression and non-linear dose-response analysis were conducted to evaluate the association between pooled effect size and folic acid dosage (mg/day) and duration of the intervention (week). From 1814 detected studies, twenty-four studies reported fasting blood glucose (FBG), fasting insulin, hemoglobin A1C (HbA1C), and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) as an outcome measure. Results: Results revealed significant reductions in FBG (weighted mean difference (WMD): −2.17 mg/dL, 95% CI: −3.69, −0.65, p = 0.005), fasting insulin (WMD: −1.63 pmol/L, 95% CI: −2.53, −0.73, p < 0.001), and HOMA-IR (WMD: −0.40, 95% CI: −0.70, −0.09, p = 0.011) following folic acid supplementation. No significant effect was detected for HbA1C (WMD: −0.27%, 95% CI: −0.73, 0.18, p = 0.246). The dose-response analysis showed that folic acid supplementation significantly changed HOMA-IR (r = −1.30, p-nonlinearity = 0.045) in non-linear fashion. However, meta-regression analysis did not indicate a linear relationship between dose, duration, and absolute changes in FBG, HOMA-IR, and fasting insulin concentrations. Conclusions: Folic acid supplementation significantly reduces some markers of glycemic control in adults. These reductions were small, which may limit clinical applications for adults with type II diabetes. Further research is necessary to confirm our findings.
Glioblastoma Multiforme—A Look at the Past and a Glance at the Future
Authors: King Jasmine L. , Benhabbour Soumya Rahima
Published: July 2021

Gliomas are the most common type of brain tumor that occur in adults and children. Glioblastoma multiforme (GBM) is the most common, aggressive form of brain cancer in adults and is universally fatal. The current standard-of-care options for GBM include surgical resection, radiotherapy, and concomitant and/or adjuvant chemotherapy. One of the major challenges that impedes success of chemotherapy is the presence of the blood–brain barrier (BBB). Because of the tightly regulated BBB, immune surveillance in the central nervous system (CNS) is poor, contributing to unregulated glioma cell growth. This review gives a comprehensive overview of the latest advances in treatment of GBM with emphasis on the significant advances in immunotherapy and novel therapeutic delivery strategies to enhance treatment for GBM.
Apple (Malus domestica Borkh.) Cultivar ‘Majda’, a Naturally Non-Browning Cultivar: An Assessment of Its Qualities
Authors: Cebulj Anka , Vanzo Andreja , Hladnik Joze , Kastelec Damijana , Vrhovsek Urska
Published: July 2021

Browning of apple and apple products has been a topic of numerous research and there is a great number of methods available for browning prevention. However, one of the most efficient ways, and the one most acceptable for the consumers, is the selection of a non-browning cultivar. Cultivar ‘Majda’ is a Slovenian cultivar, a cross between ‘Jonatan’ and ‘Golden Noble’. In this study, it was thoroughly examined and compared to the well-known cultivar ‘Golden Delicious’ with the aim to decipher the reason for non-browning. We have determined the content of sugars, organic acids, vitamin C, glutathione and phenolics in apple flesh, with the addition of phenolic content in apple peel and leaves. The change in color in halves and pomace was also measured and the activity of peroxidase (POX) and polyphenol oxidase (PPO) were determined. Additionally, the analyses of flesh were repeated post-storage. The most prominent results were high acidity (malic acid), low phenol content, especially hydroxycinnamic acid and flavan-3-ol content of cultivar ‘Majda’ in comparison to ‘Golden Delicious’, and no difference in PPO activity between cultivars. After the overview of the results, we believe that both low phenol content and high reduced glutathione content impact the non-browning characteristics of cultivar ‘Majda’.
Genome Wide MeDIP-Seq Profiling of Wild and Cultivated Olives Trees Suggests DNA Methylation Fingerprint on the Sensory Quality of Olive Oil
Authors: Badad Oussama , Lakhssassi Naoufal , Zaid Nabil , El Baze Abdelhalim , Zaid Younes , Meksem Jonas , Lightfoot David A , Tombuloglu Huseyin , Zaid El Houcine , Unver Turgay , Meksem Khalid
Published: July 2021

Secondary metabolites are particularly important to humans due to their pharmaceutical properties. Moreover, secondary metabolites are key compounds in climate change adaptation in long-living trees. Recently, it has been described that the domestication of Olea subspecies had no major selection signature on coding variants and was mainly related to changes in gene expression. In addition, the phenotypic plasticity in Olea subspecies was linked to the activation of transposable elements in the genes neighboring. Here, we investigated the imprint of DNA methylation in the unassigned fraction of the phenotypic plasticity of the Olea subspecies, using methylated DNA immuno-precipitation sequencing (MeDIP-seq) for a high-resolution genome-wide DNA methylation profiling of leaves and fruits during fruit development in wild and cultivated olives from Turkey. Notably, the methylation profiling showed a differential DNA methylation in secondary metabolism responsible for the sensory quality of olive oil. Here, we highlight for the first time the imprint of DNA methylation in modulating the activity of the Linoleate 9S lipoxygenase in the biosynthesis of volatile aromatic compounds. Unprecedently, the current study reveals the methylation status of the olive genome during fruit ripening.
The Modification of Plant Cell Wall Polysaccharides in Potato Plants during Pectobacterium atrosepticum-Caused Infection
Authors: Gorshkov Vladimir , Tsers Ivan , Islamov Bakhtiyar , Ageeva Marina , Gogoleva Natalia , Mikshina Polina , Parfirova Olga , Gogoleva Olga , Petrova Olga , Gorshkova Tatyana , Gogolev Yuri
Published: July 2021

Our study is the first to consider the changes in the entire set of matrix plant cell wall (PCW) polysaccharides in the course of a plant infectious disease. We compared the molecular weight distribution, monosaccharide content, and the epitope distribution of pectic compounds and cross-linking glycans in non-infected potato plants and plants infected with Pectobacterium atrosepticum at the initial and advanced stages of plant colonization by the pathogen. To predict the gene products involved in the modification of the PCW polysaccharide skeleton during the infection, the expression profiles of potato and P. atrosepticum PCW-related genes were analyzed by RNA-Seq along with phylogenetic analysis. The assemblage of P. atrosepticum biofilm-like structures—the bacterial emboli—and the accumulation of specific fragments of pectic compounds that prime the formation of these structures were demonstrated within potato plants (a natural host of P. atrosepticum). Collenchyma was shown to be the most “vulnerable” tissue to P. atrosepticum among the potato stem tissues. The infection caused by the representative of the Soft Rot Pectobacteriaceae was shown to affect not only pectic compounds but also cross-linking glycans; the content of the latter was increased in the infected plants compared to the non-infected ones.
A Fatigue Damage Model for Life Prediction of Injection-Molded Short Glass Fiber-Reinforced Thermoplastic Composites
Authors: Amjadi Mohammad , Fatemi Ali
Published: July 2021

Short glass fiber-reinforced (SGFR) thermoplastics are used in many industries manufactured by injection molding which is the most common technique for polymeric parts production. Glass fibers are commonly used as the reinforced material with thermoplastics and injection molding. In this paper, a critical plane-based fatigue damage model is proposed for tension–tension or tension–compression fatigue life prediction of SGFR thermoplastics considering fiber orientation and mean stress effects. Temperature and frequency effects were also included by applying the proposed damage model into a general fatigue model. Model predictions are presented and discussed by comparing with the experimental data from the literature.
The Proposal and Necessity of the Numerical Description of Nano- and Microplastics’ Surfaces (Plastisphere)
Authors: Dąbrowska Agnieszka , Gniadek Marianna , Machowski Piotr
Published: July 2021

The constantly growing amount of synthetic materials < 5 mm, called microplastics (MPs), is fragmented in the environment. Thus, their surface, Plastisphere, is substantially increasing forming an entirely new ecological niche. It has already been extensively studied by microbiologists observing the biofilm and by material scientists interested in the weathering of polymer materials. This paper aims to construct a bridge between the physical and chemical description of the Plastisphere and its microbiological and ecological significance. Various algorithms, based on the analysis of pictures obtained by scanning electron microscopy (SEM), are proposed to describe in detail the morphology of naturally weathered polymers. In particular, one can study the size and distribution of fibres in a standard filter, search the synthetic debris for mapping, estimate the grain size distribution, quantitatively characterize the different patterns of degradation for polymer spheres and ghost nets, or calculate the number of pores per surface. The description and visualization of a texture, as well as the classification of different morphologies present on a surface, are indispensable for the comprehensive characterization of weathered polymers found inside animals (e.g., fishes). All these approaches are presented as case studies and discussed within this work.
Deep Learning on Airborne Radar Echograms for Tracing Snow Accumulation Layers of the Greenland Ice Sheet
Authors: Varshney Debvrat , Rahnemoonfar Maryam , Yari Masoud , Paden John , Ibikunle Oluwanisola , Li Jilu
Published: July 2021

Climate change is extensively affecting ice sheets resulting in accelerating mass loss in recent decades. Assessment of this reduction and its causes is required to project future ice mass loss. Annual snow accumulation is an important component of the surface mass balance of ice sheets. While in situ snow accumulation measurements are temporally and spatially limited due to their high cost, airborne radar sounders can achieve ice sheet wide coverage by capturing and tracking annual snow layers in the radar images or echograms. In this paper, we use deep learning to uniquely identify the position of each annual snow layer in the Snow Radar echograms taken across different regions over the Greenland ice sheet. We train with more than 15,000 images generated from radar echograms and estimate the thickness of each snow layer within a mean absolute error of 0.54 to 7.28 pixels, depending on dataset. A highly precise snow layer thickness can help improve weather models and, thus, support glaciological studies. Such a well-trained deep learning model can be used with ever-growing datasets to aid in the accurate assessment of snow accumulation on the dynamically changing ice sheets.
From the Inquisition Pyre to Insertion into the Church: The Familial and Social Trajectory of Hernando Ortiz, a Jewish Convert in the Spanish Empire in the 16th Century
Authors: Ramirez Clara
Published: July 2021

This is a study of the trajectory of a Jewish converso who had a brilliant career at the University of Mexico in the 16th century: he received degrees from the faculties of arts, theology and law and was a professor for more than 28 years. He gained prestige and earned the respect of his fellow citizens, participated in monarchical politics and was an active member of his society, becoming the elected bishop of Guatemala. However, when he tried to become a judge of the Inquisition, a thorough investigation revealed his Jewish ancestry back in the Iberian Peninsula, causing his career to come to a halt. Further inquiry revealed that his grandmother had been burned by the Inquisition and accused of being a Judaizer around 1481; his nephews and nieces managed, in 1625, to obtain a letter from the Inquisition vouching for the “cleanliness of blood” of the family. Furthermore, the nephews founded an entailed estate in Oaxaca and forbade the heir of the entail to marry into the Jewish community. The university was a factor that facilitated their integration, but the Inquisition reminded them of its limits. The nephews denied their ancestors and became part of the society of New Spain. We have here a well-documented case that represents the possible existence of many others.
Barriers to the Practice of Sport and Physical Activity from the Perspective of Self-Determination Theory
Authors: Gil-Píriz Daniel , Leyton-Román Marta , Mesquita Sara , Jiménez-Castuera Ruth
Published: July 2021

The practice of sport and physical activity can be hampered by the presence of amotivation, the frustration of basic psychological needs, and barriers to carrying out that practice. Based on the principles of self-determination theory (SDT), the objective of this study was to analyze the relationship of these variables and assess differences based on age, sex, residential independence, academic/employment situation, and prior sport and physical activity. The sample comprised 102 individuals, aged between 18 and 25 (M = 21.61; SD = 2.04), who completed the Behavioral Regulation in Exercise Questionnaire, the Frustration of Psychological Needs in Physical Exercise Scale, and the Self-Perceived Barriers of Physical Activity Questionnaire. Our results showed that participants had high values of controlled motivation, the frustration of the basic psychological need for competence, and high values for the barrier of obligations/lack of time. We found a significant and positive association between the frustration of the basic psychological need for competence and the barriers present in the practice of physical activity. Moreover, we found that women reported experiencing body image/anxiety as a barrier to practicing sport and physical activity more than men and individuals aged 22–25 years experiencing obligations/lack of time as a barrier more than the those aged 18 to 21 years. Practical applications were proposed to avoid the frustration of basic psychological needs, increase the most self-determined forms of motivation, and reduce barriers to the practice of sport and physical activity.
Parametric Design and Comfort Optimization of Dynamic Shading Structures
Authors: Chi Doris A. , González M. Edwin , Valdivia Renato , Gutiérrez J. Eduardo
Published: July 2021

This work implements parametric tools to optimize the environmental design of urban adaptive shadings through multiobjective evolutionary algorithms that look for solutions of dynamic (time-changing) structures used in open public spaces. The proposal is located in Malecon Cancun Tajamar in the southeast part of Mexico, and the main objective is to enhance the thermal comfort of users as well as to become part of the social dynamics of the place reinforcing identity through appropriation. The proposed workflow includes four steps: (1) geometric modelling by parametric modelling tools; (2) simulation of environmental parameters by using BPS tools; (3) shape optimization by using an evolutionary algorithm; and (4) environmental verification of the results. The Universal Thermal Climate Index (UTCI) was used to assess the outdoor thermal comfort derived from the dynamic shadings. The results showed a significant improvement in the thermal comfort with absolute UTCI differences of 3.9, 7.4, and 3.1 °C at 8, 12, and 16 h, respectively, during the summer; and absolute differences of 1.4, 3.5, and 2 °C at 8, 12, and 16 h, respectively, during the winter. The proposed workflow can help to guide the early design process of dynamic shadings by finding optimal solutions that enhance outdoor thermal comfort.
Effects of Socio-Academic Intervention on Student Performance in Vulnerable Groups
Authors: Sánchez-Almeida Tarquino , Naranjo David , Gilar-Corbi Raquel , Reina Jessica
Published: July 2021

In Ecuador, affirmative action policies enable students from vulnerable groups to preferentially enter universities. However, these policies are limited to admission and do not include academic or socio-economic support mechanisms that, according to the literature, promote student insertion in the higher education system. In this study, the effects of socio-academic intervention on the academic performance of vulnerable students are presented. For this, 41 students were selected among 164 vulnerable students entering the Escuela Politécnica Nacional in the second term of 2019. The 41 students attended a socio-academic intervention course for one term, while the remaining 123 attended the Escuela Politécnica Nacional levelling course directly. Once both groups of students finished the levelling course, their performance in each of the course subjects was compared. The results showed that the academic performance of the students in the intervention was significantly higher in mathematics and geometry compared to the students who had no intervention. These results show that the socio-academic intervention promotes the real insertion of vulnerable students in the university system.