bluuebunny/crossref_metadata_2025 huggingface dataset:
Rapid Determination of Methamphetamine, Methylenedioxymethamphetamine, Methadone, Ketamine, Cocaine, and New Psychoactive Substances in Urine Samples Using Comprehensive Two-Dimensional Gas Chromatography
Authors: Chandra Siri Doreen N. B. , Goh Seng Yo , Chong Ngee Sing , Marriott Philip J. , Wong Yong Foo
Published: November 2024

Background/Objectives: This study evaluates the applicability of a comprehensive two-dimensional gas chromatography−flame ionisation detection (GC×GC−FID) approach for the simultaneous determination of 12 underivatised psychoactive drugs, including new psychoactive substances, that comprised of amphetamine, methamphetamine, mephedrone, 3,4-methylenedioxyamphetamine, 3,4-methylenedioxymethamphetamine, α-pyrrolidinovalerophenone, n-ethylpentylone (ephylone), norketamine, ketamine, 3,4-methylenedioxypyrovalerone, methadone, and cocaine. Methods: Separation was effected using a non-polar first dimension (1D) and a polar second dimension (2D) column, demonstrating an improved separation of drug compounds compared to a polar/non-polar column configuration. Interference-free baseline separation of all psychoactive compounds in a urine matrix was achieved within 8 min. The GC×GC−FID method was validated according to the guidelines defined by Standard Practices for Method Validation in Forensic Toxicology. Results: The calibration curves for the 12 psychoactive drugs were well correlated (r2 > 0.99) within the concentration ranges of 50–1500 ng mL−1. Detection limits of 10–20 ng mL−1 were obtained, and good repeatability and reproducibility (CV < 11.4%) were attained for retention times and peak areas. Method recoveries for the small-scale solvent extraction procedure ranged from 96.9 to 114.5%, and bias was between −3.1% and 14.5%. Conclusions: The validated approach was successfully applied for the determination of these illicit compounds in spiked urine samples of different concentrations, highlighting its potential for rapid forensic drug screening.
Evolution of Synoptic Systems Associated with Lake-Effect Snow Events over Northwestern Pennsylvania
Authors: Wiley Jake , Elcik Christopher
Published: November 2024

This study investigates the synoptic conditions associated with lake-effect snow (LES) over northwestern Pennsylvania with a focus on classifying cases based on the tracks of cyclones influencing the region, including Nor’easters (NEs), Alberta Clippers (ACs), Colorado Lows (COs), and Great Lakes Lows (GLs). Synoptic composites were constructed using the North American Regional Reanalysis (NARR) for all cases, as well as each cyclone group, using an LES repository spanning from 2006–2020. Additionally, 95 percent bootstrapped confidence intervals were created for each cyclone track to compare the initial mesoscale environmental properties (i.e., surface lake/air temperature and wind direction/speed) and LES impact (i.e., duration, maximum snowfall, and property damage). Synoptic composites of all LES cases exhibited an archetypal LES synoptic pattern consisting of an upper-level low geopotential height anomaly over the Hudson Bay and surface dipole structure centered across the Great Lakes basin. Regarding the different tracks, NEs and COs featured dynamic support in the form of enhanced turbulent mixing and synoptic vertical forcing, while ACs and GLs had greater thermodynamic support in the form of higher lapse rates and heightened heat and moisture fluxes. However, the bootstrapping analysis revealed minimal differences in LES impact between the cyclone types.
Study of Vertical Phototransistors Based on Integration of Inorganic Transistors and Organic Photodiodes
Authors: Chang Jui-Fen , Lin Ying-You , Li Yu-Ming
Published: November 2024

We investigate the inorganic/organic hybrid vertical phototransistor (VPT) by integrating an atomic layer deposition-processed ZnO (ALD-ZnO) transistor with a prototype poly(3-hexylthiophene):[6,6]-phenyl-C61-butyric acid methyl ester (P3HT:PC61BM) blend organic photodiode (OPD) based on an encapsulated source electrode geometry, and discuss the device mechanism. Our preliminary studies on reference P3HT:PC61BM OPDs show non-ohmic electron injection between the ALD-ZnO and P3HT:PC61BM layers. However, the ALD-ZnO layer enables the accumulation of photogenerated holes under negative bias, which facilitates electron injection upon illumination and thereby enhances the external quantum efficiency (EQE). This mechanism underpins the photoresponse in the VPT. Furthermore, we demonstrate that the gate field in the VPT effectively modulates electron injection from the ALD-ZnO layer to the top OPD, resulting in the VPT operating as a non-ohmic OPD in the OFF state and as an ohmic OPD in the ON state. Benefiting from the unique transistor geometry and gate modulation capability, this hybrid VPT can achieve an EQE of 45,917%, a responsivity of 197 A/W, and a specific detectivity of 3.4 × 1012 Jones under 532 nm illumination and low drain-source voltage (Vds = 3 V) conditions. This transistor geometry also facilitates integration with various OPDs and the miniaturization of the ZnO channel area, offering an ideal basis for the development of highly efficient VPTs and high-resolution image sensors.
Buckling Behavior Analysis of Kirigami Structure Under Tension
Authors: Dai Pengzhong , Li Ziqi , Zhang Xiaoyang , Yu Qingmin
Published: November 2024

Flexible electronic technology has attracted great interest, where rigid and brittle semiconductor materials can withstand large deformation. In order to improve the stretchability of devices, many novel structures have been designed, such as the classical “wavy” structure, the island-bridge structure, and origami structures that achieve stretchability through creases. However, the stretchability of these structures is still not large enough. Inspired by traditional kirigami, the stretchability of devices is achieved by making various periodic cuts in the substrate while the devices are placed in the area around the cuts. The previous research mainly focused on the change in the electrical properties of the structure during the deformation process, and there were few studies on the mechanical mechanisms. Therefore, this paper studies the buckling behavior of the kirigami structure when the substrate is stretched, and its mechanism can provide guidance for practical applications.
A 2-D Fully Polarized Van Atta Array Based on Wide-Beam Tri-Polarized Antennas
Authors: Pan Jicheng , Chen Lei , Zhao Shuangdi , Zhang Tianling
Published: November 2024

This paper proposes a 2-D fully polarized Van Atta array, which consists of four tri-polarized antenna elements. The tri-polarized antenna element comprises a monopole antenna and a low-profile microstrip antenna that widens the beam by folding four electric walls. This configuration enables the Van Atta arrays to receive and transmit arbitrarily polarized incident waves over a wider range. The measurement results indicate that the proposed Van Atta array exhibits a −5 dB radar cross-section (RCS) greater than 95° when TE-polarized waves are incident and greater than 134° when TM-polarized waves are incident, significantly surpassing the 2-D dual-polarized array.
Recombinant SAG2A Protein from Toxoplasma gondii Modulates Immune Profile and Induces Metabolic Changes Associated with Reduced Tachyzoite Infection in Peritoneal Exudate Cells from Susceptible C57BL/6 Mice
Authors: Santos Thaíse Anne Rocha dos , Oliveira Mário Cézar de , Silva Edson Mario de Andrade , dos Santos Uener Ribeiro , Ferreira Monaliza Macêdo , Soares Ana Luísa Corrêa , Silva Neide Maria , Mendes Tiago Antônio de Oliveira , Leal-Sena Jamilly Azevedo , Cunha-Júnior Jair Pereira da , Mineo Tiago Wilson Patriarca , Mineo José Roberto , Mendes Érica Araújo , Lima-Santos Jane , Pirovani Carlos Priminho
Published: November 2024

Toxoplasmosis is a neglected disease that represents a significant public health problem. The antigenic profile of T. gondii is complex, and the immune response can lead to either susceptibility or resistance. Some antigens, such as surface antigen glycoprotein (SAG), are expressed on the surface of tachyzoite stages and interact with the host immune cells. In this study, we investigated the potential of the recombinant SAG2A protein of T. gondii to control parasitism and modulate the immune response in the peritoneal exudate cells (PECs) of both susceptible (C57BL/6) and resistant (BALB/c) mice using an in vitro infection model, gene expression, proteomic analysis, and bioinformatic tools. Our results showed that rSAG2A-treated PECs presented a lower parasitism in C57BL/6 mice but not in the PECs from BALB/c mice, and induced a pro-inflammatory cytokine profile in C57BL/6 mice (iNOS, TNF-α, and IL-6). rSAG2A modulated different exclusive proteins in each mouse lineage, with PECs from the C57BL/6 mice being more sensitive to modulation by rSAG2A. Additionally, biological processes crucial to parasite survival and immune response were modulated by rSAG2A in the C57BL/6 PECs, including fatty acid beta-oxidation, reactive oxygen species metabolism, interferon production, and cytokine-mediated signaling pathways. Together, our study indicates that rSAG2A controls T. gondii parasitism in susceptible C57BL/6 PECs through the modulation of pro-inflammatory cytokines and enhanced expression of proteins involved in the cytotoxic response.
Analysis of Microbial Community Heterogeneity and Carbon Fixation Capabilities in Oil-Contaminated Soils in Chinese Onshore Oilfields
Authors: Song Jiayu , Chen Yakui , Han Yilei , Li Yunzhao , Liu Zheng , Li Xingchun , Lu Diannan , Chen Chunmao
Published: November 2024

This study selected 27 soil samples from four representative horizontally distributed onshore oilfields in China to explore the diversity of soil microbial communities and their carbon fixation capacity, with a focus on the potential interaction between pollution and carbon fixation under oil pollution stress. The analysis of the soil physicochemical properties and microbial community structures from these oilfield samples confirmed a clear biogeographic isolation effect, indicating spatial heterogeneity in the microbial communities. Additionally, the key factors influencing microbial community composition differed across regions. The dominant bacterial phyla of soil microorganisms under soil pollution stress were Proteobacteria, Actinobacteriota, Chloroflexi, Acidobacteriota, Firmicutes, Bacteroidota, and Gemmatimonadota. A correlation network analysis identified Immundisolibacter, Acinetobacter, Blastococcus, Truepera, and Kocuria as key players in the microbial network, with most showing positive correlations. The results of the KEGG database functional annotation showed that degradation and carbon fixation metabolic pathways coexist in soil samples and maintain a balanced relative abundance. These metabolic pathways highlight the functional diversity of microorganisms. Among them, prokaryotic and eukaryotic carbon fixation pathways, along with benzoate degradation pathways, are predominant. These findings establish a theoretical basis for further exploration of the synergistic mechanisms underlying pollution reduction and carbon sequestration by microorganisms in petroleum-contaminated soils.
New Accountability Approach: Utilising Dynamic Zero-Waste Baselines to Mitigate Water Wastage in Gold Mines
Authors: Jordaan Erik George , van Rensburg Johann , du Preez Jamie
Published: November 2024

The South African gold mining industry requires complex water reticulation systems to deliver chilled water to underground production areas. However, chilled- and service-water wastage, including leaks and misuse, contribute to approximately 50% of the total chilled-water demand. The current inefficiency detection methods rely on broad, infrequent, and labour-intensive work, focusing only on identifying and quantifying wastages without comprehensive mitigation strategies. This study aimed to develop a novel accountability framework employing dynamic zero-waste baselines to identify and address inefficiencies closer to active working areas. The proposed method incorporates four key components—define, assess, execute, and communicate—into an accountability system to monitor performance and ensure sustainable improvements. The integration of dynamic zero-waste baselines within this accountability framework will ensure faster and more accurate inefficiency detection and, more importantly, the mitigation thereof, significantly reducing water wastage. This study successfully reduced the daily water wastage, with an annual energy cost benefit of approximately USD 1.6 million (ZAR 28.7 million). The successful implementation of this method met all the research objectives, confirming its effectiveness.
Precision Synthesis of Conjugated Polymer Films by Surface-Confined Stepwise Sonogashira Cross-Coupling
Authors: Youm Sang Gil , Howell Mitchell T. , Chiang Chien-Hung , Lu Lu , Kuruppu Arachchige Neepa M. K. , Ankner John F. , Strzalka Joseph , Losovyj Yaroslav , Garno Jayne C. , Nesterov Evgueni E.
Published: November 2024

Thin films of poly(arylene ethynylene)-conjugated polymers, including low-energy-gap donor–acceptor polymers, can be prepared via stepwise polymerization utilizing surface-confined Sonogashira cross-coupling. This robust and efficient polymerization protocol yields conjugated polymers with a precise molecular structure and with nanometer-level control of the organization and the uniform alignment of the macromolecular chains in the densely packed film. In addition to high stability and predictable and well-defined molecular organization and morphology, the surface-confined conjugated polymer chains experience significant interchain electronic interactions, resulting in dominating intermolecular π-electron delocalization which is primarily responsible for the electronic and spectroscopic properties of polymer films. The fluorescent films demonstrate remarkable performance in chemosensing applications, showing a turn-off fluorescent response on the sub-ppt (part per trillion) level of nitroaromatic explosives in water. This unique sensitivity is likely related to the enhanced exciton mobility in the uniformly aligned and structurally monodisperse polymer films.
Development of an Electrochemical Paper-Based Device Modified with Functionalized Biochar for the Screening of Paracetamol in Substandard Medicines
Authors: Silva Martin Kassio Leme da , Barreto Francisco Contini , Sousa Guilherme dos Santos , Simões Rafael Plana , Ahuja Gaurav , Dutta Samriddha , Mulchandani Ashok , Cesarino Ivana
Published: November 2024

The global prevalence of counterfeit and low-quality pharmaceuticals poses significant health risks and challenges in medical treatments, creating a need for rapid and reliable drug screening technologies. This study introduces a cost-effective electrochemical paper-based device (ePAD) modified with functionalized bamboo-derived biochar (BCF) for the detection of paracetamol in substandard medicines. The sensor was fabricated using a custom 3D-printed stencil in PLA, designed for efficient production, and a 60:40 (m/m) graphite (GR) and glass varnish (GV) conductive ink, resulting in a robust and sensitive platform. The electroactive area of the ePAD/BCF sensor was determined as 0.37 cm2. Characterization via SEM and cyclic voltammetry (CV) verified its structural and electrochemical stability. The sensor demonstrated linear detection of paracetamol from 5.0 to 60.0 µmol L−1 with a detection limit of 3.50 µmol L−1. Interference studies showed high selectivity, with recoveries of over 90%, and the sensor successfully quantified paracetamol in commercial analgesic and anti-flu samples. This sustainable, bamboo-based ePAD offers a promising solution for rapid on-site pharmaceutical quality control, with significant potential to enhance drug screening accuracy.
Enhancing Antileishmanial Activity of Amidoxime-Based Compounds Bearing a 4,5-Dihydrofuran Scaffold: In Vitro Screening Against Leishmania amazonensis
Authors: Maia Santos Urbancg Moncorvo Fabiana , Avendaño Leon Oscar Leonardo , Curti Christophe , Kabri Youssef , Redon Sébastien , Torres-Santos Eduardo Caio , Vanelle Patrice
Published: November 2024

Leishmaniasis, a protozoan disease affecting humans, exposes significant shortcomings in current treatments. In continuation to our previous findings on amidoxime-based antileishmanial compounds bearing a 4,5-dihydrofuran scaffold, twelve new amidoxime derivatives substituted at position 3 with an amide bearing a nitrogen heterocycle were synthesized. This series was designed to replace the sulfone and aryl group on a previously reported HIT. The synthesis of these compounds involved the following three-step pathway: manganese (III) acetate-based cyclization of a β-ketoester, followed by amidation with LiHMDS and a final reaction with hydroxylamine. Three of them, containing either bromine, chlorine, or methyl substitutions and featuring a pyridine moiety, showed an interesting toxicity–activity relationship in vitro. They exhibited IC50 values of 15.0 µM, 16.0 µM, and 17.0 µM against the promastigote form of the parasite and IC50 values of 0.5 µM, 0.6 µM, and 0.3 µM against the intracellular amastigote form, respectively. A selectivity index (SI) greater than 300 was established between the cytotoxic concentrations (in murine macrophages) and the effective concentrations (against the intracellular form of Leishmania amazonensis). This SI is at least seventy times higher than that observed for Pentamidine and twenty-five times higher than that observed for the reference HIT, as previously reported.
Cannabigerol (CBG): A Comprehensive Review of Its Molecular Mechanisms and Therapeutic Potential
Authors: Li Shijia , Li Weini , Malhi Naseeb Kaur , Huang Junwei , Li Quanqi , Zhou Ziwei , Wang Ruiheng , Peng Jiangling , Yin Tong , Wang Honggen
Published: November 2024

Cannabigerol (CBG), a non-psychoactive cannabinoid found in cannabis, has emerged as a promising therapeutic agent with a diverse range of potential applications. Unlike its well-known counterpart tetrahydrocannabinol (THC), CBG does not induce intoxication, making it an attractive option in the clinic. Recent research has shed light on CBG’s intriguing molecular mechanisms, highlighting its potential to modulate multiple physiological processes. This review delves into the current understanding of CBG’s molecular interactions and explores its therapeutic power to alleviate various conditions, including cancer, metabolic, pain, and inflammatory disorders, amongst others. We discuss how CBG interacts with the endocannabinoid system and other key signaling pathways, such as CB1, CB2, TPR channels, and α2-adrenoceptor, potentially influencing inflammation, pain, neurodegeneration, and other ailments. Additionally, we highlight the ongoing research efforts aimed at elucidating the full spectrum of CBG’s therapeutic potential and its safety profile in clinical settings. Through this comprehensive analysis, we aim to provide a deeper understanding of CBG’s role in promoting human health and pave the way for future research endeavors.
Photochemical Hydroxyl Group Abstraction from N-Hydroxypyridine-2(1H)-thione Isolated in a Solid Hydrogen Matrix: Photogeneration of 2-Mercaptopyridine
Authors: Rostkowska Hanna , Nowak Maciej J. , Reva Igor , Lapinski Leszek
Published: November 2024

Monomers of N-hydroxypyridine-2(1H)-thione were isolated in low-temperature matrices of solid normal hydrogen (n-H2). The matrix-isolated compound was irradiated with UV-B (λ = 305 nm) or UV-A (λ > 360 nm) light. Upon such irradiation, the initial form of N-hydroxypyridine-2(1H)-thione was completely consumed and converted into photoproducts. 2-Mercaptopyridine and water were identified as the main products of these photochemical transformations. Identification of photoproduced 2-mercaptopyridine is unquestionable. It is based on the identity of two sets of IR bands: (i) the bands observed in the IR spectrum recorded (in a separate experiment) for monomers of 2-mercaptopyridine trapped in an n-H2 matrix and (ii) a set of IR bands observed in the spectrum recorded after UV irradiation of N-hydroxypyridine-2(1H)-thione. It should be emphasized that the UV-induced processes, occurring for N-hydroxypyridine-2(1H)-thione isolated in an n-H2 matrix, lead to products that are significantly different from those generated from the compound trapped in solid Ar or in solid N2.
Mutational Analysis of Substrate Recognition in Trypsin-like Protease Cocoonase: Protein Memory Induced by Alterations in Substrate-Binding Site
Authors: Sakata Nana , Shimamoto Shigeru , Murakami Yuri , Ashida Orika , Takei Toshiki , Miyazawa Mitsuhiro , Hidaka Yuji
Published: November 2024

To investigate the substrate recognition mechanism of trypsin-like protease cocoonase (CCN), mutational analyses were conducted at key substrate recognition sites, Asp187 and Ser188, and their effects on substrate specificity and enzymatic activity were evaluated. Mutants with the Asp187 substitution exhibited a significant reduction in catalytic activity compared with the wild-type enzyme, whereas the Ser188 mutants displayed a comparatively minor effect on activity. This indicates that Asp187 plays a crucial role in catalytic function, whereas Ser188 serves a complementary role in substrate recognition. Interestingly, the substitution of the Asp187 to Glu or Ser caused novel substrate specificities, resulting in the recognition of Orn and His residues. In addition, when Asp187 and Ser188 were substituted with acidic residues (Glu or Asp), both the precursor proCCN and mature CCN proteins retained highly similar secondary and tertiary structures. This reveals that the structural characteristics of precursor proteins are maintained in the mature proteins, potentially influencing substrate recognition and catalytic function. These findings suggest that the pro-regions of these mutants interact much more tightly with the mature enzyme than in the wild-type CCN. These results provide fruitful insights into the structural determinants governing substrate recognition in enzyme variants.
Facile Preparation of High-Performance Polythiophene Derivative and Effect of Torsion Angle Between Thiophene Rings on Electrochromic Color Change
Authors: Guo Qingfu , Sun Chao , Li Yiran , Li Kaoxue , Tai Xishi
Published: November 2024

The electrochromic phenomenon of conducting polymer is mainly dominated by the π-π* band transition. The π conjugation is influenced by the coplanarity between polymer units, deviations from which can lead to an increased ionization potential and band gap values. In order to investigate the effect of plane distortion angle on electrochromic color in the main chain structure of polymerization, high-performance poly(3,3′-dimethyl-2,2′-bithiophene) (PDMeBTh) with a large plane distortion angle is successfully synthesized in boron trifluoride diethyl etherate (BFEE) by the electrochemical anodic oxidation method. The electrochemical and thermal properties of PDMeBTh prepared from BFEE and ACN/TBATFB are compared. The electrochromic properties of PDMeBTh are systematically investigated. The PDMeBTh shows a different color change (orange-yellow in the neutral state) compared to poly (3-methylthiophene) (light-red in the neutral state) due to the large torsion angle between thiophene rings of the main polymer chain. The optical contrast, response time, and coloring efficiency (CE) of the prepared PDMeBTh are also studied, which shows good electrochromic properties. For practical applications, an electrochromic device is fabricated by the PDMeBTh and PEDOT. The color of the device can be reversibly changed between orange-yellow and dark blue. The light contrast of the device is 27% at 433 nm and 61% at 634 nm. The CE value of the device is 403 cm2 C−1 at 433 nm and 577 cm2 C−1 at 634 nm. The constructed device also has good open circuit memory and electrochromic stability, showing good potential for practical applications.
Structure, Optical and Electrical Properties of Nb(Zn) Doped Sol–Gel ITO Films: Effect of Substrates and Dopants
Authors: Gartner Mariuca , Szekeres Anna , Simeonov Simeon , Covei Maria , Anastasescu Mihai , Preda Silviu , Calderon-Moreno Jose Maria , Predoana Luminita , Stroescu Hermine , Mitrea Daiana , Nicolescu Madalina
Published: November 2024

We present comparative studies of sol–gel ITO multilayered films undoped and doped with Nb or Zn (4 at.%). The films were obtained by successive depositions of five layers using the dip-coating sol–gel method on microscopic glass, SiO2/glass, and Si substrates. The influence of the type of substrates and dopant atoms on the structure and optical properties of the sol–gel ITO thin films is examined and discussed in detail. XRD patterns of these layers showed a polycrystalline structure with an average crystallite size of <11 nm. Raman spectroscopy confirmed the chemical bonding of dopants with oxygen and showed the absence of crystallized Nb(Zn)-oxide particles, indicated by the XRD pattern. Spectroscopic Ellipsometry and AFM imaging revealed a clear dependence of the optical parameters and surface morphology of the ITO and ITO:Nb(Zn) thin films on the type of substrates and dopants. The analysis of the current-voltage and capacitance-voltage characteristics of the Al/ITO/Si structures revealed the presence of charge carrier traps in the ITO bulk and the ITO-Si interface. The densities of these traps are obtained and the character of the current transport mechanism is established.
Experimental and DFT Approaches to Physico-Chemical Properties of Bioactive Resveratrol Analogues
Authors: Kovačević Borislav , Šagud Ivana , Drmić Katarina Marija , Mlakić Milena , Škorić Irena , Babić Sandra
Published: November 2024

Acetylcholinesterase and butyrylcholinesterase are two related enzymes that represent pharmacologically suitable targets in neurodegenerative disorders, given their physiological roles in the body. The treatment of neurodegenerative disorders currently includes common reversible cholinesterase inhibitors. Resveratrol analogues, as the molecules in focus, have shown the very strong inhibition potential of cholinesterases. In this research, experimental and DFT approaches for their pKa value determination were carried out knowing that pKa is very important for predicting the ADMET properties of the potentially bioactive molecules and their behavior in the environment. An in silico study was used to calculate more indicators about the absorption and distribution in the human body. Among the investigated compounds, the weakest acid was experimentally detected and confirmed using three computational models. Additionally performed calculations provided access to the potential of each resveratrol analogue to engage in both π-π stacking and hydrogen bond interactions in the active site of the enzyme crucial for the stability of the ligand–enzyme complex.
Synthesis and Characterization of Microcapsules as Fillers for Self-Healing Dental Composites
Authors: Tăut Maria Amalia , Moldovan Marioara , Filip Miuţa , Petean Ioan , Saroşi Codruţa , Cuc Stanca , Taut Adrian Catalin , Ardelean Ioan , Lazăr Viorica , Man Sorin Claudiu
Published: November 2024

This article proposes the synthesis and characterization of (triethylene glycol dimethacrylate–N,N-dihydroxyethyl-p-toluidine) TEGDMA-DHEPT self-healing microcapsules for their inclusion in dental composite formulations. The obtaining method is the in situ emulsion polymerization of the (poly urea-formaldehyde) (PUF) coatings. The microcapsules were characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), atomic force microscopy (AFM), high-performance liquid chromatography (HPLC), and low-field nuclear magnetic resonance (NMR) techniques. The optimal formation of uniform microcapsules is achieved at a stirring speed of 800 rpm and centrifugation is no longer necessary. HPLC demonstrates that the microcapsules formed at 800 rpm show a better control of liquid release than the heterogeneous ones obtained at a lower stirring speed. The centrifuged samples have rounded shapes, with dimensions between 80 and 800 nm, while the non-centrifuged samples are more uniform, with a spherical shape and dimensions of approximately 800 nm.
Recent Progress on Advanced Flexible Lithium Battery Materials and Fabrication Process
Authors: Zhou Mi , Han Daohong , Cui Xiangming , Wang Jingzhao , Chen Xin , Wang Jianan , Sun Shiyi , Yan Wei
Published: November 2024

Flexible energy storage devices have attracted wide attention as a key technology restricting the vigorous development of wearable electronic products. However, the practical application of flexible batteries faces great challenges, including the lack of good mechanical toughness of battery component materials and excellent adhesion between components, resulting in battery performance degradation or failure when subjected to different types of deformation. It is imperative to develop flexible batteries that can withstand deformation under different conditions and maintain stable battery performance. This paper reviews the latest research progress of flexible lithium batteries, from the research and development of new flexible battery materials, advanced preparation processes, and typical flexible structure design. First, the types of key component materials and corresponding modification technologies for flexible batteries are emphasized, mainly including carbon-based materials with flexibility, lithium anode materials, and solid-state electrolyte materials. In addition, the application of typical flexible structural designs (buckling, spiral, and origami) in flexible batteries is clarified, such as 3D printing and electrospinning, as well as advanced fabrication techniques commonly used in flexible materials and battery components. Finally, the limitations and coping strategies in the practical application of flexible lithium batteries are discussed, which provides new ideas for future research.
Tuning Intermediate Band Solar Cell Efficiency: The Interplay of Electric Fields, Composition, Impurities, and Confinement
Authors: Abboudi Hassan , En-nadir Redouane , Basyooni-M. Kabatas Mohamed A. , El Baraka Ayoub , Ez-zejjari Ilyass , El Ghazi Haddou , Sali Ahmed
Published: November 2024

In this study, we investigated the influence of structural parameters, including active region dimensions, electric field intensity, In-composition, impurity position, and potential profiles, on the energy levels, sub-gap transitions, and photovoltaic characteristics of a p-GaN/i-(In, Ga)N/GaN-n (p-QW-n) structure. The finite element method (FEM) has been used to solve numerically the Schrödinger equation. We found that particle and sub-gap energy levels are susceptible to well width, electric field, and impurity position. Particle energy decreases with increasing well size and electric field intensity, while impurity position affects energy based on proximity to the well center. Potential profile shapes, such as rectangular (RQW) and parabolic (PQW), also play a significant role, with PQW profiles providing stronger particle confinement. IB width increases with electric field intensity and saturates at higher In-content. Voc increases with field strength but decreases with In-content, and the parabolic profile yields higher efficiency than the rectangular one. Photovoltaic efficiency is improved with an appropriately oriented electric field and decreases with higher In-content and field intensity. These findings highlight the critical role of structural parameters in optimizing QW-IBSC performance.
Slow-Release Fertilisers Control N Losses but Negatively Impact on Agronomic Performances of Pasture: Evidence from a Meta-Analysis
Authors: Abhiram Gunaratnam
Published: November 2024

High nitrogen (N) losses and low nitrogen utilisation efficiency (NUE) of conventional-nitrogen fertilisers (CNFs) are due to a mismatch between N-delivery and plant demand; thus, slow-release N fertilisers (SRNFs) are designed to improve the match. A quantitative synthesis is lacking to provide the overall assessment of SRNFs on pasture. This meta-analysis analyses application rate and type of SRNFs on N losses and agronomic performances with 65 data points from 14 studies in seven countries. Standardized mean difference of SRNFs for nitrate leaching losses and N2O emission were −0.87 and −0.69, respectively, indicating their effectiveness in controlling losses. Undesirably, SRNFs had a more negative impact on dry matter (DM) yield and NUE than CNFs. Subgroup analysis showed that SRNF type and application rate had an impact on all tested parameters. The biodegradable coating-type of SRNF outperformed other types in controlling N losses and improving agronomic performances. High application rates (>100 kg N ha−1) of SRNFs are more effective in controlling N losses. In conclusion, SRNFs are more conducive to controlling N losses, but they showed a negative impact on yield and NUE in pasture. Further studies are recommended to assess the efficacy of SRNFs developed using advanced technologies to understand their impact on pastoral agriculture.
Integrating Hydrodynamic Modeling with Ecological Risk Assessment for Selecting Sites for Artificial Reef Deployment: Avoiding Coastal Pollution Risks in Kish Island, Persian Gulf
Authors: Doust Shadan Nasseri , Abbasian Mehrnoosh , Haghshenas S. Abbas , Risk Michael J. , Downs Craig A.
Published: November 2024

The decline of natural coral reefs has spurred interest in artificial reef construction and reef rehabilitation efforts. However, many restoration programs are failing because of poor water quality and localized pollution factors. This paper examines one etiology of coral restoration failure, highlighting the need for careful site selection based on hydrodynamic, biological, and pollution criteria. Using Kish Island as a case study, we outline a procedure for determining placement of artificial reefs to minimize external pollution impacts, which could be applied to any reef site worldwide. Our integration of computational modeling and geographic information systems enables the tracking of pollution dispersion and increases the power of restoration efforts. The RQ Plume modeling, used alongside compound pollutant modeling, can identify hotspots with the highest potential to degrade marine environments, particularly reefs. Conservation efforts should prioritize pollution mitigation, as seen in the case of sunscreen pollutants at Kish Island, where regulatory action and public education can contribute to reef protection. This comprehensive approach underscores the critical role of water quality in successful reef restoration and conservation strategies.
Repeat Versus Primary Photorefractive Keratectomy for Treatment of Myopia
Authors: Mimouni Michael , Nemet Arie Y. , Ben Ephraim Noyman Dror , Rabina Gilad , Yossefi Avia , Kaiserman Igor
Published: November 2024

Although effective, a portion of photorefractive keratectomy (PRK) patients will suffer residual myopia or relapse to myopic regression. This retrospective, non-randomized, comparative study, aimed to compare the efficacy of primary PRK versus PRK performed as retreatment after previous surgery for myopia. Data regarding the right eye of 220 consecutive myopic patients undergoing repeat or primary PRK in 2013–2017 were extracted. Groups were matched for demographics and preoperative spherical equivalent, sphere, astigmatism, uncorrected and corrected distance visual acuity (UDVA and CDVA). Primary outcomes were an efficacy index (ratio between the postoperative UDVA and the preoperative CDVA), a safety index (ratio between the postoperative and the preoperative CDVA), postoperative UDVA and CDVA, and deviation from target refraction. Primary PRK showed significant superiority in logMAR UDVA (0.01 ± 0.05 versus 0.05 ± 0.10, p = 0.001), logMAR CDVA (0.01 ± 0.05 versus 0.04 ± 0.08, p = 0.01), efficacy index (1.00 ± 0.05 versus 0.97 ± 0.09, p = 0.003) and safety index (1.00 ± 0.06 versus 0.98 ± 0.08, p = 0.04) compared to repeat PRK, but had a significantly higher share of patients with postoperative spherical equivalent (74.5% versus 67.3%) and cylinder (74.5% versus 68.2%) in the range of ±0.5 D. To conclude, enhancement PRK leads to inferior efficacy and safety with greater deviation from target refraction. Adjusted nomograms for repeat PRK may be warranted.
Optimization of Laser-Patterned Superhydrophilic–Superhydrophobic Surfaces on 304 Stainless Steel for Enhanced Fog Water Collection
Authors: Chen Hongda , Zhao Jingnan , Ma Wenjian , Guo Zhiquan , Cui Yuanchen
Published: November 2024

This study focuses on creating micro-nano structures on the surface of 304 stainless steel using nanosecond lasers to achieve superhydrophobicity for fog water collection experiments in a fog chamber. By adjusting pattern parameters, an uneven wettability surface was processed, and six samples were placed at different positions in the chamber to study water collection efficiency from various surfaces. The experimental results indicate that the water collection efficiency of the patterned superhydrophobic surface is superior to that of the original surface, with the front sample collecting 0.4524 ± 0.005 g of water, representing a 90.38% improvement. As the kinetic energy of the fog flow gradually diminishes, a total of 1.1913 ± 0.005 g of water was collected, achieving a 60.25% improvement. The study also investigates the durability and optimal temperature conditions for fog water collection, ultimately achieving 1.4781 ± 0.005 g of water collection in a 5 °C fog environment, resulting in a 98.83% enhancement.
Efficacy of Triphala and Chlorhexidine Mouthwashes on Gingival Inflammation and Dental Plaque in Children: A Systematic Review
Authors: Singaraju Anuja , Nuvvula Sivakumar , Rudravaram Venkata Ratna Kumar , Anchala Karthik , Venkata Saikiran Kanamarlapudi , Mallineni Sreekanth Kumar
Published: November 2024

Aim: The aim of this study was to evaluate and compare the efficacy of Triphala and chlorhexidine mouthwashes in reducing gingivitis and dental plaque in children. Methodology: A literature search was confined to the English language using MeSH terms conferring to PICO format in PubMed, Cochrane Library, and Ovid (SP), covering the period from January 1960 to August 2022. A search in Google Scholar and the grey literature and a hand search of references was performed to find additional data. Suitable studies were selected based on the predefined inclusion and exclusion criteria. Quality analysis of the selected studies was performed using the Cochrane Risk of Bias Tool for Randomized Controlled Trials. Results: Seven hundred and forty-seven articles were retrieved from three databases (PubMed, Cochrane Library, Ovid (SP), and other sources). Results: A total of 747 studies were retrieved from electronic databases and hand searches. After removing duplications, 519 were available; among them, 495 irrelevant citations were excluded with inclusion and exclusion criteria. Twenty-four citations were eligible for abstract screening, and fourteen citations were excluded including invitational studies, narrative reviews, animal studies, and studies that involved adults. Finally, studies for full texts were screened for eligibility for the research question, and then only five studies were available upon full-text phase analysis. The five studies involved 1740 children to evaluate the efficacy of Triphala and chlorhexidine mouthwashes in reducing gingivitis and dental plaque in children. Among them, one article showed low risk, three articles showed moderate risk, and one article showed high risk. Conclusion: While Triphala and chlorhexidine both reduce gingivitis, reports indicate that Triphala is less effective than chlorhexidine in improving plaque index scores. Further controlled studies are needed to confirm the effectiveness of Triphala mouthwash in children.
General Three-Body Problem in Conformal-Euclidean Space: New Properties of a Low-Dimensional Dynamical System
Authors: Gevorkyan Ashot S. , Bogdanov Aleksander V. , Mareev Vladimir V.
Published: November 2024

Despite the huge number of studies of the three-body problem in physics and mathematics, the study of this problem remains relevant due to both its wide practical application and taking into account its fundamental importance for the theory of dynamical systems. In addition, one often has to answer the cognitive question: is irreversibility fundamental for the description of the classical world? To answer this question, we considered a reference classical dynamical system, the general three-body problem, formulating it in conformal Euclidean space and rigorously proving its equivalence to the Newtonian three-body problem. It has been proven that a curved configuration space with a local coordinate system reveals new hidden symmetries of the internal motion of a dynamical system, which makes it possible to reduce the problem to a sixth-order system instead of the eighth order. An important consequence of the developed representation is that the chronologizing parameter of the motion of a system of bodies, which we call internal time, differs significantly from ordinary time in its properties. In particular, it more accurately describes the irreversible nature of multichannel scattering in a three-body system and other chaotic properties of a dynamical system. The paper derives an equation describing the evolution of the flow of geodesic trajectories, with the help of which the entropy of the system is constructed. New criteria for assessing the complexity of a low-dimensional dynamical system and the dimension of stochastic fractal structures arising in three-dimensional space are obtained. An effective mathematical algorithm is developed for the numerical simulation of the general three-body problem, which is traditionally a difficult-to-solve system of stiff ordinary differential equations.
Social Media Use and Fear of Missing out: An Exploratory Cross-Sectional Study in Junior High Students from Western Mexico
Authors: Maciel-Saldierna Manuel , Méndez-Garavito Ignacio Roberto , Elizondo-Hernandez Emmanuel , Fuentes-Orozco Clotilde , González-Ojeda Alejandro , Ramírez-Ochoa Sol , Cervantes-Pérez Enrique , Vicente-Hernández Berenice , Vázquez-Sánchez Sergio Jiram , Chejfec-Ciociano Jonathan Matías , Cervantes-Guevara Gabino
Published: November 2024

Background/Objectives: The increased use of social media in Mexico has given rise to the “fear of missing out” (FoMO) phenomenon, especially among adolescents. This study aimed to measure the extent of FoMO among junior high school students in the metropolitan area of Guadalajara, Mexico, during the COVID-19 pandemic. Additionally, this study explored the association between FoMO levels and demographic characteristics, as well as the type and frequency of social media use. Methods: A cross-sectional survey was conducted from November 2021 to January 2022 in four junior high schools. A total of 1264 students (656 females and 608 males) aged 11–16 years completed the Fear of Missing Out Scale, adapted to the Mexican context. Data on demographics, social media usage, and school shifts were collected. Statistical analyses were performed using t-tests, ANOVA, and correlation coefficients. Results: The mean FoMO score was 1.79 ± 0.64, with higher scores observed in females (p < 0.001) and students attending morning shifts (p = 0.001). Significant associations were found between higher FoMO scores and the use of social media platforms like Instagram, TikTok, and Pinterest (p < 0.001 for each). The most frequently used social media platforms were WhatsApp (1093), TikTok (828), and Instagram (583). Participants who used social media all week exhibited significantly higher FoMO scores than those who used it only on weekends (p < 0.001). Conclusions: FoMO is a significant phenomenon among junior high school students in Guadalajara, Mexico, particularly among females and those who use multiple social media platforms. The findings suggest a need for interventions to manage social media use and mitigate FoMO-related negative health outcomes in this population.
Development and Evaluation of Lactose-Free Single-Unit and Multiple-Unit Preparations of a BCS Class II Drug, Rivaroxaban
Authors: Zakowiecki Daniel , Edinger Peter , Papaioannou Markos , Wagner Michael , Hess Tobias , Paszkowska Jadwiga , Staniszewska Marcela , Myslitska Daria , Smolenski Michal , Dobosz Justyna , Garbacz Grzegorz , Haznar Garbacz Dorota
Published: November 2024

Background/Objectives: The aim of the present study was to develop lactose-free formulations of rivaroxaban, a novel oral anticoagulant used for the treatment and prevention of blood clotting. As a BCS Class II drug, rivaroxaban is characterized by poor solubility in aqueous media, posing a significant formulation challenge. Methods: To address this, phosphate-based excipients were employed to prepare both traditional single-unit dosage forms (tablets) and modern multiple-unit pellet systems (MUPS). These formulations were successfully developed and thoroughly evaluated for their physical properties and performance. Results: The resulting formulations demonstrated very good mechanical strength, including appropriate hardness and friability, alongside strong chemical stability. Their dissolution profiles met the requirements of the compendial monograph for Rivaroxaban Tablets and were comparable to those of the reference product, Xarelto® film-coated tablets. Conclusions: This study shows the potential for producing effective, stable, and patient-friendly medications that meet the needs of contemporary society, where an increasing number of individuals suffer from lactose intolerance or seek vegan-friendly alternatives.
Induced Emission on Transitions from Vibrational Excited Levels of the KrF Molecule
Authors: Yampolskaya Sofia , Yastremskii Arcady , Panchenko Yuri , Puchikin Alexey , Bobrovnikov Sergey
Published: November 2024

The paper considers the possibility of extending the spectral region of the wavelength tuning of a discharge KrF amplifier due to induced transitions from the vibrational excited states of the electronic level B. The model of the KrF amplifier on a He/Kr/F2 mixture is presented, in which the behavior of the vibrational level populations is consistent with the excitation conditions of the active medium. The simulation results show that the shift in the operating wavelength to the short-wavelength region is possible in excitation modes, when the birth rate of excimer molecules is greater than the rate of their relaxation from upper to lower vibrational levels. The theoretical dependences of gain on the wavelength for different pressures were obtained. They confirm the possibility of tuning the KrF amplifier wavelength in the range of up to 10 nm while maintaining a gain of at least 0.5 of its maximum value.
Exploring Changes in Ocular Aberrations for Different Fixation and Accommodation Stimuli
Authors: Mechó-García María , Macedo-de-Araújo Rute J. , Fernandes Paulo , González-Méijome José Manuel
Published: November 2024

Background: Given the lack of standardization in stimulus types for assessing accommodation, we aimed to evaluate accommodative response (AR) and Zernike coefficients using four different stimuli. Methods: Sixteen healthy subjects aged 22–32 years participated. Four black transilluminated stimuli (Snellen 6/12 “E”, 6/6 “e”, Maltese Cross 6/12 “X”, 6/6 “x”) were used to stimulate accommodation from 0 D to 5 D, in 1 D increments, using the irx3 aberrometer. From the results, AR was calculated with Seidel defocus and the change in Zernike coefficient value between the non-accommodative state and the fully accommodative state (5 D) was determined. Results: Larger pupils were observed with stimulus “E” (p-value < 0.05). The mean AR at the maximum accommodative level (5 D) for the different stimuli was −1.88 ± 1.00 for “E”, −2.60 ± 1.44 for “X”, −2.00 ± 1.32 for “e”, and −2.40 ± 1.27 for “x”. No statistically significant differences were found between AR and Zernike coefficients with the four different accommodative stimuli (p-value > 0.05, one-way ANOVA). Conclusions: The study evaluated accommodative stimulus design and size on AR and Zernike coefficients and found no significant differences. However, stimuli with higher spatial frequencies (“e” and “E”) provided larger ARs compared to the other stimuli.