bluuebunny/crossref_metadata_2025 huggingface dataset:
Rancang Bangun Sistem Informasi Aplikasi E-Voting Pemilihan Ketua Osis Berbasis Web
Authors: Wulan Damar , Hamzah Muhammad Luthfi
Published: June 2024

Pembuatan aplikasiiE- Voting dilakukanisebagai upaya dalam membantu pemilihan ketua OSIS di SMK Hasanah Pekanbaru, dimana dalam proses pemilihannya kurang berjalan dengan maksimal, karena masih menggunakan sistem konvensional. Penelitian ini bertujuan untuk menghasilkan produk E-Voting yang efektif dan tersistem. E-Votingimerupakan sebuah perangkat pemberian suara secara elektronik. Software yang digunakan dalam pembuatan web ini menggunakan Xampp daniMySQL untuk pengelolaan database. Metode penelitian yang digunakan dalam pembuatan rancang bangun sistem informasi E-Voting ini menggunakan metode Agile. Adapun tahapan pada penelitian ini yaitu: (1) Perencanaan, (2) Implementasi, (3) Tes Perangkat Lunak, (4) Dokumentasi, (5) Deployment, (6) Pemeliharaan. Berdasarkan penelitian yang telah dilakukan, pembuatan sistem informasi E-Voting dapat memberikan kemudahan bagi SMK Hasanah Pekanbaru dalam melakukan pemilihan ketua OSIS dan membantu mempercepat prosesi perhitungan suara.
Analisis Sentimen Pengguna Instagram terhadap Kebijakan Nadiem Makarim yang Memperbolehkan Mahasiswa Lulus Tanpa Skripsi menggunakan Metode Analisis VADER dan Metode Klasifikasi Naïve Bayes
Authors: Rofran Kirk Ezra , Kaunang Fergie Joanda
Published: June 2024

Instagram, sebagai media sosial yang populer, telah mendapat banyak perhatian dari para peneliti untuk digunakan sebagai wadah pengambilan data untuk melakukan analisis sentimen. Di dalam penelitian ini, dilakukan Analisis Sentimen terhadap pengguna Instagram terkait Kebijakan Nadiem Makarim yang memperbolehkan mahasiswa lulus tanpa skripsi. Peneliti mengumpulkan data yang berupa komentar dari unggahan pengguna Instagram yang berkaitan dengan kebijakan Nadiem Makarim. Metode analisis Valence Aware Dictionary for sEntiment Reasoning (VADER) dan metode klasifikasi Naïve Bayes digunakan untuk menganalisis data yang diambil dari unggahan pengguna Instagram. VADER digunakan untuk menilai sentimen umum dalam unggahan, sementara Naïve Bayes digunakan untuk mengklasifikasikan sentimen menjadi kategori positif, negatif, atau netral. Hasil penelitian ini memberikan wawasan mendalam tentang bagaimana pengguna Instagram merespon kebijakan Nadiem Makarim. Pada penelitian ini,algoritma klasifikasi Naïve Bayes diterapkan pada pengujian data sebanyak 508 komentar, yang merupakan 25% dari total data. Hasilnya menunjukkan bahwa penggunaan TF-IDF memberikan akurasi sebesar 71.29%. Hal ini menunjukkan bahwa TF-iDF memberikan akurasi yang tinggi dalam analisis sentimen, dengan sebagian besar masyarakat memberikan respon positif terhadap kebijakan tersebut. Saran untuk penelitian selanjutnya adalah melakukan analisis sentimen menggunakan metode klasifikasi algoritma lain seperti Support Vector Machine (SVM), Random Forest, atau Neural Network untuk mendapatkan pemahaman yang lebih komprehensif mengenai respons masyarakat terhadap kebijakan tersebut. Studi lebih lanjut juga dapat melibatkan analisis dampak jangka panjang dari kebijakan ini terhadap dunia pendidikan dan masyarakat, serta eksplorasi aspek-aspek yang belum terungkap dalam komentar publik. Adanya keragaman dalam penggunaan algoritma klasifikasi dapat memberikan wawasan yang lebih mendalam.
Perancangan Video Edukasi Pelestarian Lingkungan Alam oleh Pendaki Gunung
Authors: Nadita Florensia , Setyawan Martin , Prasida T. Arie Setiawan , Bezaleel Michael
Published: June 2024

Pendakian gunung saat ini menjadi salah satu kegiatan yang populer, namun meningkatnya jumlah pendaki tidak selaras dengan pemahaman mengenai dampak negatifnya terhadap lingkungan. Dalam penelitian ini akan dibahas tentang peningkatan vandalisme dan kerusakan alam yang disebabkan oleh pendaki di Gunung Mebabu, maka dari itu perlu media edukasi terhadap para pendaki untuk ikut andil dalam pelestarian alam. Video sinematik dibuat sebagai media edukasi untuk pendaki pemula, dengan fokus pada remaja akhir berusia 17-25 tahun. Penelitian ini menggunakan metode kualitatif deskriptif. Dari hasil pengujian video edukasi  berhasil menyampaikan informasi dan edukasi tentang pentingnya menjaga kelestarian alam pegunungan khususnya kawasan pendakian Gunung Merbabu. Bedasarkan hasil diatas dapat disimpulkan video edukasi penelitian ini dapat mengedukasi pentingnya partisipasi masyarakat dan pendaki gunung untuk turut andil melestarikan alam di jalur pendakian Gunung Merbabu.
Optimalisasi Pengelolaan Aset Berbasis Web Dalam Peningkatan Efisiensi Dan Keberlanjutan
Authors: Cahyaningrum Yunnita , Sambharakreshna Yudhanta
Published: June 2024

Aset merupakan modal penting yang menunjang kinerja, oleh karena itu pengidentifikasian, pengelolaan, dan perawatan aset dengan baik sangatlah penting agar pemanfaatannya menjadi efektif dan efisien. Salah satu pengembangan sistem dalam operasional aset berbasis web adalah SIM Aset. Dengan berbagai fitur dan kemudahan yang dimilikinya, SIM Aset membawa dampak positif dalam efisiensi pengelolaan aset di Badan Pengelola Keuangan dan Aset Daerah Kabupaten Nganjuk. Penelitian ini menggunakan metode kualitatif. Untuk mengetahui efektivitas sistem ini dilakukan pengamatan langsung dan wawancara dengan pihak terkait. Hasil penelitian ini mengungkap bahwa SIM Aset dinilai mampu mengoptimalkan pengelolaan aset, hal ini terbukti dengan adanya peningkatan waktu yang dirasa lebih efisien dalam perhitungan penyusutan yang lebih akurat dan berkurangnya resiko terlewatnya pencatatan aset.
Penerapan Deep Learning Menggunakan Convolutional Neural Network (CNN) Untuk Klasifikasi Daging Ayam Menggunakan Arsitektur Resnet-50
Authors: Sulistia Febri Yalda , Vatresia Arie
Published: June 2024

Daging ayam adalah salah satu konsumsi paling tinggi bagi manusia dalam kehidupan sehari-hari karena mengandung banyak gizi dan sumber protein yang tinggi.  Pada umumnya, jenis ayam yang sering dikonsumsi masyarakat adalah daging ayam kampung dan daging ayam broiler yang dimana mulai dari cara perawatan dan pemeliharaan ayam sangat berbeda sehingga menentukan kualitas daging ayam tersebut. Perawatan ayam broiler yang dilakukan oleh peternak ayam kerap mengabaikan  prosedur kesehatan ayam sehingga banyak memunculkan potensi bahaya mengkonsumsi daging ayam broiler seperti terkena infeksi bakteri Salmonella dan Campylobacter karena dalam masa perawatan dan pertumbuhan ayam sering disuntik antibiotik. Masyarakat perlu tahu dengan permasalahan ini dan masalah ini menjadi sangat serius jika dihubungkan dengan adanya beberapa kandungan dalam ayam broiler yang tidak boleh dikonsumsi oleh orang tertentu seperti logam berat. Secara kasat mata, tekstur daging ayam kampung dan daging ayam broiler sangatlah mirip maka dari itu dibutuhkan sebuah teknologi untuk membedakan kedua jenis daging tersebut berdasarkan tekstur yang dianalisis. Penggunaan deep learning dalam perkembangan teknologi untuk mengolah sebuah citra sangat efektif, maka dari itu penelitian ini menggunakan metode Deep Learning yaitu Convolutional Neural Network (CNN) menggunakan arsitektur ResNet-50 sebagai klasifikasi daging dengan jumlah data sebanyak 1.200 citra dengan 2 kelas yaitu daging ayam kampung dan daging ayam broiler dengan setiap kelas memiliki ukuran gambar 224 224 pixel dan pembagian data dengan perbandingan data ayam kampung 80%  data latih : 20% data uji dan ayam broiler dengan perbandingan 80% data latih : 20% data latih. Setelah penelitian dilakukan, maka hasil perolehan akurasi tertinggi dari penelitian ini adalah pengujian ke-10  dengan 55% accuracy, 55% precision, 55% recall, dan 55% f1 score dengan menggunakan parameter optimizer SGD,  learning rate,  batch size, dan momentum. Dari penelitian ini dapat disimpulkan bahwa penggunaan arsitektur ResNet-50 sangat baik dalam pengklasifikasian citra dengan tingkat akurasi yang sangat tinggi.
Progressive Web Application Berbasis Arsitektur Microservice Pada Sistem Pelayanan Persuratan (Studi Kasus: Kelurahan Karang Anyar Kota Bandung)
Authors: Fauzi Esa , Prasetyo Bagus Alit , Purnama Adi
Published: June 2024

Transformasi digital telah menjadi kebutuhan penting dalam upaya meningkatkan efisiensi dan kualitas layanan publik. Penelitian ini berfokus pada desain dan implementasi sistem pelayanan persuratan berbasis Progressive Web Application (PWA) dan arsitektur microservice di Kelurahan Karang Anyar, Kota Bandung. Tujuan utama dari penelitian ini adalah untuk menciptakan sistem persuratan yang lebih responsif, skalabel, dan mudah diakses oleh masyarakat. Metode penelitian yang digunakan meliputi analisis kebutuhan, perancangan sistem, implementasi teknologi PWA dan microservices, serta evaluasi kinerja sistem. Hasil dari penelitian ini menunjukkan bahwa sistem persuratan berbasis PWA memberikan pengalaman pengguna yang lebih baik dengan kemampuan akses offline, responsivitas tinggi, dan instalasi yang mudah pada berbagai perangkat. Sementara itu, arsitektur microservice memungkinkan pengembangan dan pemeliharaan sistem yang lebih fleksibel, modular, dan scalable. Evaluasi sistem dilakukan melalui pengujian fungsional dan kinerja, serta survei kepuasan pengguna. Hasil pengujian menunjukkan peningkatan signifikan dalam kecepatan pemrosesan surat, kemudahan akses, dan kepuasan pengguna dibandingkan dengan sistem persuratan konvensional. Penelitian ini menyimpulkan bahwa implementasi PWA dan arsitektur microservice pada sistem pelayanan persuratan di Kelurahan Karang Anyar dapat menjadi model yang efektif untuk diterapkan di wilayah lainnya dalam rangka meningkatkan pelayanan publik.
Integrasi Metode Kano Dengan Quality Function Deployment (QFD) Untuk Meningkatkan Kualitas Produk Kerupuk Ikan
Authors: Aironic M.Ridhwan Nuruddi Caesareno , Hidayat Hidayat , Negoro Yanuar Pandu
Published: June 2024

Persaingan di industri kerupuk ikan semakin ketat. Banyak produsen lain yang juga mencoba memasuki pasar dengan berbagai inovasi baru baik dari segi rasa maupun kemasan. Oleh sebab itu, perusahaan dirasa penting untuk terus melakukan pengembangan produk agar dapat tetap bersaing dan mempertahankan pangsa pasarnya. Dalam penelitian ini, metode Kano dan QFD yang digunakan. Tujuan Metode Kano adalah untuk mengetahui apa yang diinginkan konsumen tentang produksi kerupuk, dan QFD adalah untuk menawarkan saran yang paling penting untuk meningkatkan kualitas. Hasil penelitian menunjukkan bahwa Kano memiliki 6 atribut one-dimensional, 4 atribut must-be, 2 atribut Attractive, dan untuk atribut Indefferent tidak mendapat grade. Di sisi lain, hasil penelitian QFD menunjukkan bahwa pengujian validitas ketiga tingkatan menghasilkan nilai R hitung yang lebih dari R table 0,532, yang menunjukkan bahwa atribut valid sementara uji reliabilitas menunjukkan bahwa nilai alpha dari ke-3 tingkatan menghasilkan nilai dan jawaban responden dianggap konsisten.
Evaluasi Pengalaman Pengguna Website Responsif Beyondsultra
Authors: Nuzry Kartini Aprilia Pratiwi , Suryani Erma
Published: June 2024

Tourism is a crucial sector in the economy of a region, and the use of digital technology in the tourism industry is steadily increasing. The responsiveness of a tourism website is a key factor influencing users' perceptions and experiences with the Beyondsultra website. Beyondsultra is a tourism website for Southeast Sulawesi created by the City of Kendari Regional-Owned Enterprise. The research aims to identify the responsiveness of the Beyondsultra website in influencing user perceptions of the quality of their user experience and to provide appropriate recommendations for the company to enhance user satisfaction with the Beyondsultra website. The selected respondents for the study are potential tourists and active users of the Beyondsultra website. Based on data obtained from user satisfaction observations while interacting with the Beyondsultra website using the User Experience Questionnaire (UEQ) and System Usability Scale (SUS) methods, above-average results were obtained for UEQ. Subsequently, a reevaluation was conducted to delve deeper into the issues faced by users, utilizing Cooperative Evaluation techniques. The research findings indicate an improvement in user satisfaction with the Beyondsultra website using the UEQ method, with a 68% increase in attractiveness, 93% in clarity, 91% in efficiency, 100% in stimulation, and 63% in novelty. However, one aspect, precision, remained unchanged after evaluation. In the SUS method, the average assessment score showed a 15% improvement.
Perspectivas de uma comunicação para paz em relação à cobertura jornalística brasileira sobre o conflito palestino-israelense
Authors: Paschoal Baldin Vitória , Osvald Ramos Daniela
Published: June 2024

O presente trabalho investiga como o conflito palestino-israelense foi representado nas matérias jornalisticas veículadas no portal G1 ao longo do primeiro semestre de 2023 a partir de uma abordagem de jornalismo para paz. Para avaliar o uso relativo do enquadramento paz/guerra, as classificações de codificação dos enquadramentos da paz se basearam no trabalho de Galtung (1986, 1998), bem como nos critérios utilizados por Lee e Maslog (2005). Estas categorias de codificação envolvem vários indicadores de enquadramentos do jornalismo de paz que foram usados de modo a compreender se tal produção continha encaminhamentos para paz. Argumentamos que embora haja exemplos de matérias que seguem os princípios do jornalismo para a paz, há espaço para melhorias na cobertura midiática desse conflito.
O medo da cidade ou a cidade do medo?
Authors: Costa Alda Cristina Silva da , Santos Antônio Pedro Pimentel
Published: June 2024

Quais são as lentes através das quais temos acessado a realidade da cidade: a da experiência vivida ou da midiatização das narrativas jornalísticas? Essa provocação permeia as reflexões do presente artigo com a finalidade de compreender outra importante indagação no contemporâneo: o medo da cidade ou a cidade do medo? Tais argumentações fazem parte da construção de uma Hermenêutica do Medo, provenientes da interpretação das relações estabelecidas, hoje, com as cidades. São observações emergidas em 11 anos de pesquisa nas interações entre mídia e violência[1]. Os achados iniciais indicam um fio condutor em que a experiência das pessoas se confunde com as informações provindas da mídia.
 
[1] Desde de 2012, já realizamos três projetos de pesquisa denominados: “Mídia e Violência: as narrativas midiáticas na Amazônia paraense” (2012-2015); “Mídia e Violência: percepções e representações na Amazônia” (2017-2020); e “Mídia e Violência: sentidos e significados na Amazônia (2022 até hoje). Todos realizados na Universidade Federal do Pará em parceria com a Universidade da Amazônia e Conselho Nacional de Desenvolvimento Científico e Tecnológico – CNPq, edital Universal.
A desinformação como ferramenta de violência política de gênero
Authors: Santos Alves Gabriela , Lacerda Silva Elisa
Published: June 2024

Este artigo busca analisar o uso da desinformação como ferramenta da violência política de gênero enfrentada por mulheres durante o exercício de seus mandatos eletivos. Um levantamento bibliográfico conduz a discussão sobre informações intencionalmente falsas, desinformação de gênero, e sobre violência política de gênero no cenário brasileiro. A desinformação é  debatida como uma forma de disputa de narrativa e investigada como uma forma de manutenção de sistemas sociais hegemônicos. Isso porque, como destaca Rêgo (2021), a conceituação dos componentes da desordem informacional de Wardle e Derakshan (2017), ainda se mostram insuficientes. Após o levantamento de conteúdo onde houve desinformação usada como ferramenta de violência política de gênero, dois episódios foram escolhidos para que se aplicasse a análise de discurso: i) Erika Hilton apontada como ministra da educação do governo Lula e ii)  ii) Deputado Nikolas Ferreira sobe à tribuna da Câmara dos Deputados de peruca no dia Internacional da Mulher. Assim como Archenti e Albaine (2018), entende-se que aspectos negativos que envolvem a existência política de mulheres devem ser analisados para que caminhos que superem essas questões sejam apontados.
Impulsionando a paz e o entendimento intercultural: perspectivas antropológicas e comunicacionais.
Authors: Victor Cilene , Alzoubi Ahmad
Published: June 2024

Entrevista com Kholoud al-Ajarma
LOST OBJECTS OF DESIRE
Authors: Nicholls Mark
Published: June 2024

This first book-length critical study of Jeremy Irons concentrates on his key performances and acting style. Through the analysis of some of the major screen roles in Irons’s career, such as Brideshead Revisited, The French Lieutenant’s Woman, Reversal of Fortune, Swann in Love, Dead Ringers and Lolita, Mark Nicholls identifies a new masculine identity that unites them: an emblematic figure of the 1980s and 1990s presented as an alternative to the action hero or the common man. Using clear explanations of complex theoretical ideas, this book investigates Jeremy Irons’s performances through the lens of sexual inversion and social rebellion, to uncover an entirely original but recognizable screen type.
FORTUNE AND THE CURSED
Authors: Swancutt Katherine
Published: June 2024

Innovation-making is a classic theme in anthropology that reveals how people fine-tune their ontologies, live in the world and conceive of it as they do. This ethnographic study is an entrance into the world of Buryat Mongol divination, where a group of cursed shamans undertake the ‘race against time’ to produce innovative remedies that will improve their fallen fortunes at an unconventional pace. Drawing on parallels between social anthropology and chaos theory, the author gives an in-depth account of how Buryat shamans and their notion of fortune operate as ‘strange attractors’ who propagate the ongoing process of innovation-making. With its view into this long-term ‘cursing war’ between two shamanic factions in a rural Mongolian district, and the comparative findings on cursing in rural China, this book is a needed resource for anyone with an interest in the anthropology of religion, shamanism, witchcraft and genealogical change.
WOMEN OF TWO COUNTRIES
Authors: Bank Michaela
Published: June 2024

German-American women played many roles in the US women’s rights movement from 1848 to 1890. This book focuses on three figures—Mathilde Wendt, Mathilde Franziska Anneke, and Clara Neymann—who were simultaneously included and excluded from the nativist women’s rights movement. Accordingly, their roles and arguments differed from those of their American colleagues, such as Susan B. Anthony, Elizabeth Cady Stanton, or Lucy Stone. Moreover, German-American feminists were confronted with the opposition to the women’s rights movement in their ethnic community of German-Americans. As outsiders in the women’s rights movement they became critics; as “women of two countries” they became translators of feminist and ethnic concerns between German- Americans and the US women’s rights movement; and as messengers they could bridge the gap between American and German women in a transatlantic space. This book explores the relationship between ethnicity and gender and deepens our understanding of nineteenth-century transatlantic relationships.
ANYONE
Authors: Rapport Nigel
Published: June 2024

The significance that people grant to their affiliations as members of nations, religions, classes, races, ethnicities and genders is evidence of the vital need for a cosmopolitan project that originates in the figure of Anyone – the universal and yet individual human being. Cosmopolitanism offers an alternative to multiculturalism, a different vision of identity, belonging, solidarity and justice, that avoids the seemingly intractable character of identity politics: it identifies samenesses of the human condition that underlie the surface differences of history, culture and society, nation, ethnicity, religion, class, race and gender. This book argues for the importance of cosmopolitanism as a theory of human being, as a methodology for social science and as a moral and political program.
A DURKHEIMIAN QUEST
Authors: Watts Miller William
Published: June 2024

Durkheim, in his very role as a ‘founding father’ of a new social science, sociology, has become like a ﬁgure in an old religious painting, enshrouded in myth and encrusted in layers of thick, impenetrable varnish. This book undertakes detailed, up-to-date investigations of Durkheim’s work in an effort to restore its freshness and reveal it as originally created. These investigations explore his particular ideas, within an overall narrative of his initial problematic search for solidarity, how it became a quest for the sacred and how, at the end of his life, he embarked on a project for a new great work on ethics. A theme running through this is his concern with a modern world in crisis and his hope in social and moral reform. Accordingly, the book concludes with a set of essays on modern times and on a crisis that Durkheim thought would pass but which now seems here to stay.
Interview with Translator Edward Gauvin
Authors: Gabel Aubrey
Published: June 2024

In this interview, award-winning translator and author Edward Gauvin reflects on his practice as a translator of over four hundred graphic novels, including works by major French comics artists, illustrators, and scriptwriters, such as Gébé, Marjane Satrapi, Alejandro Jodorowsky, Emmanuel Guibert, Joann Sfar, Lewis Trondheim, Zeina Abirached, Christophe Blain, Philippe Druillet, Enki Bilal, Blutch, and so on. He discusses how he approaches the theoretical and practical problems he has encountered as a translator—from well-trodden topics like speech balloon fit to his dynamic understanding of genre fiction. He also offers an insider's perspective on translators’ (often precarious) position within the larger the comics industry and talks about his favourite translations, as well as his current and future projects.
Analysis of Mothers-in-Laws' Negotiation with Patriarchy through Gender Perspectives
Authors: Malik Hira , Riaz Samina , Anjum Fareeha
Published: June 2024

This study is investigating the power relationship between mothers-in-law and daughters-in-law through qualitative research design, to understand dimensions of their relationships and how their behavior endorse patriarchy into the culture. Six mothers of sons whose daughter in laws are living with them and six mothers of married daughters who were living with their in-law were included in the sample. Semi-structured interviews were conducted and transcribed interviews were analyzed. Findings revealed that mothers-in-law negotiate with patriarchy in domestic affairs, promote control of men on resources and decision making, and do not challenge their authority. They control their daughters-in-law in household whether it is domestic, financial, family matter, and social mobility, yet allow them to do jobs and spend their earnings on themselves.Daughters-in-laws are also negotiating with patriarchy for adopting professional choices, dealing with household responsibilities and dealing with personal matters.
ACTN4-dependent regulation of double-strand DNA break repair is independent of NF-Kb activity
Authors: Kriger D. V. , Vasileva G. V. , Lomerta E. V. , Tentler D.  G.
Published: June 2024

α-Actinin-4 is an actin-binding protein that is involved in a wide range of cellular processes. Along with actin and other proteins of the actin cytoskeleton, α-actinin-4 was found not only in the cytoplasm, but also in the nucleus of various cells. As a nuclear protein, it is involved in regulation of certain transcription factors. In particular, it can regulate transcriptional activity of NF-kB, which largely determines the resistance of cancer cells to apoptosis and anticancer therapy. During our previous studies, it was found that α-actinin-4 can influence resistance of cancer cells to topoisomerase II inhibitors and determine the efficiency of DNA double-strand break repair. We have demonstrated that α-actinin-4 interferes with the assembly of complexes involved in DNA repair via NHEJ and HRR, which in turn leads to an imbalance between these pathways. In this study, we were answering to the question of how α-actinin-4 is involved in the regulation of the DNA double-strand breaks repair following genotoxic stress. Our results indicate that the effect of α-actinin-4 on repair progression in H1299 non-small cell lung cancer cells does not depend on the transcription factor NF-kB activity. We found that in the nucleus of H1299 cells, α-actinin-4 is localized not only in the nucleoplasm, but also reveals close association with chromatin.
Analysis of the role of Nav1.5 slow inactivation in the development of inherited cardiac pathology
Authors: Zaytseva A. K. , Perepelina K. I. , Kostareva A. A.
Published: June 2024

Voltage-gated cardiac sodium channels Nav1.5 are responsible for the initiation and propagation of action potentials in cardiomyocytes. Dysfunction of Nav1.5 can be caused both by pathogenic variants in the SCN5A gene itself, which encodes Nav1.5, and by genetic variants in the genes of other proteins, regulating channel activity and trafficking. The change of different phases of the action potential is determined by the strict temporal organization of activation and inactivation of various ion channels. Transitions between channel functional states (for example, to slow inactivated state) can be influenced by various factors and proteins interacting with the channel. Despite the fact that the process of slow inactivation of the channel has been known for several decades, its role in the mechanism of development of hereditary heart pathology remains unclear. In this work, using the patch clamp method in whole-cell leads, we studied changes in the process of slow Nav1.5 inactivation under the influence of various mutations in structural genes (DSP-H1684R, LMNA-R249Q, FLNC-R1267Q, FLNC-V2264M) associated with a genetically determined myocardial pathology leading to dysfunction of cardiomyocytes. The study used a model of cardiomyocytes differentiated from induced pluripotent stem cells (СM-iPSCs). We have demonstrated an increase in slow inactivation in the model of CM-iPSCs obtained from patients with a phenotype of cardiomyopathy combined with ventricular arrhythmias. Thus, this work contributes to understanding the role of the slow inactivation process in the mechanism of the development of heart pathology.
Interaction of pRb and beta-catenin in cancer and normal tissue in the human prostate
Authors: Ryabov V. M. , Tyapkin N. I. , Rodimzev A. P. , Lyublinskaya O. G. , Guzhova I. V. , Popov B. V.
Published: June 2024

Prostate cancer (PCa) is one of the most common oncological diseases, which goes through two stages in its development. The first stage, localized prostate cancer, can proceed indefinitely in a dormant form that does not require active medical intervention, or suddenly turn into an aggressive metastatic form with lethal outcome. The pathogenesis of the transition of the dormant form of PCa to the metastatic form remains not fully understood. The signaling pathways of the tumor suppressor pRb and the proto-oncogene β-catenin are probably the most involved in the pathogenesis of PCa but the role of their interaction in the pathogenesis of prostate cancer has not been studied. The publication on the pathogenesis of tumors in other tissues suggests that pRb may lose some properties of a tumor suppressor at the initial stage of PCa development due to its interaction with β-catenin that enables tumor cells to gain competitive advantages for reproduction. In this work, we have shown that the RB and β-catenin (CTNNB1) genes are well expressed in tumor and normal prostate tissue. Unlike β-catenin, pRb is not detected by immunoblotting in tumor and normal prostate tissue, but is easily determined in this way in extracts of control T98G cells. Co-immunoprecipitation with antibodies to pRb from extracts of tumor and normal prostate tissue makes it possible to detect this protein and β-catenin by subsequent immunoblotting, which indicates the physical interaction of these proteins in prostate tissue. On the other hand, immunoprecipitation of β-catenin with antibodies to its C-terminal fragment does not detect this protein in prostate extracts by subsequent immunoblotting using the same antibody. In contrast to prostate tissue, β-catenin is readily detected by immunoprecipitation combined with immunoblotting in T98G control cell extracts. The obtained data suggest that pRb and β-catenin physically interact with each other in cells of different tissue specificity. In T98G cells, this interaction probably occurs through the C-terminal fragment of β-catenin, but in prostate cells it occurs in a different way, since the C-fragment of β-catenin is shielded from such interaction, possibly due to its physical association with pRb.
Development of Green Composite Utilizing Sisal Strands and Sustainable 3-D Printed PLA Layers
Authors:   Department of Textile Technology, Federal Technical and Vocational Training Institute, Addis Ababa, Ethiopia, Ramaiah Gurumurthy , Tilahun Asmare ,   Department of Textile Technology, Federal Technical and Vocational Training Institute, Addis Ababa, Ethiopia, Negawo Tolera A. ,   Department of Textile Technology, Federal Technical and Vocational Training Institute, Addis Ababa, Ethiopia, Baraki Senay Yacob ,   Department of Textile Technology, Federal Technical and Vocational Training Institute, Addis Ababa, Ethiopia, Legese Robel ,   Department of Textile Technology, Federal Technical and Vocational Training Institute, Addis Ababa, Ethiopia, Asfaw Daniel ,   Department of Textile Technology, Federal Technical and Vocational Training Institute, Addis Ababa, Ethiopia
Published: June 2024

PLA/Sisal hybrid composites have been used in cars and technical textile applications. When utilized in composites, 3-D-printed PLA layers can improve performance and homogeneity. The primary goal of this research was to use sisal and 3-D-printed polylactic acid (PLA) layers to develop a sustainable bio-composite. To enhance the bonding of sisal fibres with the PLA matrix, sisal fibres were given a sodium hydroxide treatment. This would improve the mechanical and thermal properties of composites. Sisal fibre (between 4 wt% and 8 wt%), epoxy concentration (between 85 wt% and 90 wt%), and PLA 3-D printing infilling percentage (between 90 wt% and 100 wt%) were the independent parameters. The Taguchi L8 orthogonal array design was used to make the composite samples. The changes in the amounts of PLA infill, epoxy matrix concentration, and sisal fibre content were considered for test sample development. The optimal settings for improving their tensile, flexural, and impact capabilities were determined by analyzing their signal-to-noise ratio (S/N). The PLA/sisal fibre composite showed a remarkable level of mechanical properties in Sample 8, surpassing those of the other samples. To improve mechanical and thermal properties, the appropriate values for sisal fibre composition, PLA infilling percentage, and epoxy concentration percentage were 8 per cent, 95 per cent, and 85 per cent, respectively. After testing, the tensile (293–295.4 Megapascal) (Mpa), impact (2.73–4.84 Mpa), and flexural strength (188.5–270.4 Mpa) results show that the new composite has better mechanical behaviour properties. Additionally, FTIR, SEM, and DSC experiments were run to examine the composite's structural characteristics. Using less volatile epoxy resin, a sustainable 3-D-printed PLA layer and Sisal fibre bio-composite were developed.
Relationship between Supervision and Organizational Commitment of Workers in Lesure Facilities for the Elderly: Dual Mediating Effect of Professionalism Perception and Self-leadership
Authors:   Korea Gerontological Society, Lee Byoung Rock
Published: June 2024

This study analyzed the relationship between supervision, professionalism awareness, and self-leadership, which are various variablesrelated to organizational commitment that can raise the level of leisure welfare facilities for older adults. Questionnaires were distributedto 375 workers in 19 facilities in Daejeon and Chungcheongnam-do through SPSS and Amos 18.0 program. Confirmatory factor and structuralequation model analysis were used as important analysis methods. The analysis results are as follows: Firstly, the supervision of workershas a significant effect on organizational commitment. Secondly, the paths of major variables were all significant. Thirdly, the dual mediatingeffect of professionalism awareness and self-leadership was confirmed. The measures to improve workers’ organizational commitment andto provide high quality leisure services are as follows. Firstly, for enhancing the supervision for the workers, it is necessary to educatethe supervisor to balance the detailed supervision, to develop the operating system and manual of the specific supervision, and to includethe supervision in the facility evaluation. Secondly, in order to improve workers’ professionalism perception, it is necessary to provideprofessional deepening education, to examine the type of social worker qualification examination, and to create an environment to improvethe professionalism voluntarily. Thirdly, for developing their self-leadership, it is desirable to include various supports of managers,self-leadership in job training and appropriate compensation for work performance caused by self-leadership.
Study on the Effectiveness of Person-Centered Communication Intervention Using EEG
Authors:   Korea Gerontological Society, Kim Dongseon , Yoo DooHan
Published: June 2024

Person-Centered care and communication intervention have been widely utilized in emotional care for people with dementia overseas. However, the use of non-pharmacological interventions, including person-centered care, has been lacking in Korea primarily due to a shortageof scientific evidence proving their efficacy. This study aimed to present Person-Centered communication as a method of intervention andto quantitatively assess its impact on the emotional state and agitation of people with dementia. The subjects of the study, people withmild dementia who commute day care centers, were divided into experimental and control groups for the purpose of comparison. Measurementson brainwaves and observations on changes in emotion and behavior were taken before and after the interventions. Brainwaves were examined by measuring signals from two electrodes of EEG on the prefrontal cortex, and observation were taken with the Observed Emotion RateScale (OERS) and the Agitation Behavior Scale (ABS). As a result of the communication intervention, it was found that emotions such as happiness and attentiveness increased, while anger, anxiety·agitation, and sadness decreased, along with a reduction in agitated behavior. EEG measurements showed a decrease in theta waves which are related to emotions, and significant changes in alpha and beta waves whichare related to attentiveness. This study is meaningful in that it quantitatively confirmed the effectiveness of Person-Centered communicationon the emotions and agitated behavior, as well as EEG changes in people with mild dementia. This study suggests using Person-Centered Care and communication intervention for the emotional support of people with dementia.
Tingkat Pengetahuan Masyarakat Tentang Penggunaan Obat Tradisional di Desa Landungsari Kecamatan Pekalongan Timur Kota Pekalongan
Authors: Aulia Risti , Ermawati Nur
Published: June 2024

Latar bekalang : Indonesia merupakan negara kepulauan yang terletak di daerah tropis serta memiliki keanekaragaman hayati yang melimpah dan dapat digunakan sebagai bahan baku obat. Pengetahuan masyarakat tentang pengobatan tradisional dengan pemanfaatan tanaman herbal merupakan salah satu warisan budaya turun temurun dari nenek moyang kepada generasi berikutnya.

Tujuan : Penelitian ini bertujuan untuk mengetahui tingkat pengetahuan masyarakat tentang penggunan obat tradisional di Desa Landungsari Kecamatan Pekalongan Timur Kota Pekalongan.

Metode :Jenis penelitian ini menggunakan penelitian observasional yang bersifat deskriptif dengan pendekatan metode kualitatif. Teknik pengambilan sampel dengan menggunakan purposive sampling. Populasi dalam penelitian ini adalah masyarakat RW 14 di Desa Landungsari Kota Pekalongan yang berjumlah 1,754 orang dan sampel yang dipilih dalam penelitian ini sebanyak 95 responden. Analisis data penelitian ini bersifat deskriptif dengan pengukuran analisis data menggunakan Skala Guttman.

Hasil : Hasil penelitian menunjukkan bahwa tingkat pengetahuan masyarakat tentang penggunaan obat tradisional di Desa Landiungsari dari ketiga tingkatan yaitu baik, cukup dan kurang. Tingkat pengetahuan baik 39 responden (41,0%), tingkat pengetahuan cukup 47 responden (49,5%) dan tingkat pengetahuan kurang 9 responden (9,5%). Rata rata tingkat pengetahuan masyarakat RW 14 di Desa Landungsari

Kesimpulan : Tingkat pengetahuan masyarakat tentang penggunaan obat tradisional di Desa Landungsari Kecamatan Pekalongan Timur Kota Pekalongan dapat disimpulkan bahwa rata rata tingkat pengetahuan masyarakat RW 14 Desa Landungsari adalah cukup.
Kata kunci: Pengetahuan, Obat Tradisional, Masyarakat.
The Effect of Audit Opinion, Reputation of Public Accounting Firm on Audit Delay with Audit Tenure as Moderation in Indonesian Manufacturing Companies
Authors: Widodo Teguh , Khanifah Khanifah , Astuti Wulan Budi , Hidayatusshiva Salsa
Published: June 2024

This study aims to analyze audit opinion and KAP reputation that affect audit delay with audit tenure as a moderator in manufacturing companies listed on the Indonesia Stock Exchange in 2018 â€“ 2020. In this study, audit opinion and KAP reputation are independent variables, and audit delay is a variable. dependent, tenure audit as a moderating variable.
The population of this research is all manufacturing companies listed on the Indonesia Stock Exchange in 2018 â€“ 2020. The total sample used is 135 companies which were determined through purposive sampling. The data analysis technique used is multiple linear analysis techniques with the help of the IBM SPSS 25 program.
The results of this study indicate that audit opinion has no effect on audit delay. KAP reputation affects audit delay.
EFFECTIVENESS OF THE ROLE OF LEADERS ON STUDENT ORGANIZATIONAL PERFORMANCE (EMPIRICAL STUDY OF ORMAWAS FEB UNWAHAS PERIOD 2021/2022)
Authors: Rohmah Siti Umi Sa'adatur , Rohim Fatkhur , Bahri Saiful
Published: June 2024

There is a difference between the theory of leaders and the reality of organizational conditions. In one of the student organizations the Faculty of Economics and Business has not been able to influence members to carry out their duties. And it's different from the other 4 institutions where leaders can influence members to carry out their duties properly. The leader has been able to carry out the theory of the leader as a director and influence so that members can carry out their duties following the responsibilities that have been given. The type of research used in this research is qualitative research, the qualitative research used is descriptive. And the location of the research conducted was at the Faculty of Economics and Business, Wahid Hasyim University, Semarang. From the results of the research findings, in general, the leaders at Ormawa FEB have carried out their responsibilities well. Judging from the role of the leader as a planner, the leader can plan and make decisions carefully. Leaders also have good morale that can influence their members. Communication at Ormawa FEB is quite good but not optimal, and the leader's work performance is good with the embodiment of excellent work programs at several institutions in the student organization of the Faculty of Economics and Business, Wahid Hasyim University Semarang for the 2021/2022 period.
THE INFLUENCE OF DIGITAL MARKETING, BRAND AMBASSADOR, AND PRICE ON ERIGO PRODUCT PURCHASE DECISION
Authors: Putra Duta Herzego , Octavia Ayu Nurafni , Laksono Priyo Aji
Published: June 2024

This research is based on the decline of the Erigo Brand as the Top Local Clothing Brand in 2021 to 2022 by 2.9 percent. So research is needed to improve purchasing decisions influenced by digital marketing, brand ambassadors, and Erigo brand prices carried out in the World's Best JKT48 Community. This research was conducted using a survey method among members of the World's Best JKT48 Community who are members of the Discord server, totaling 94 respondents. Data collection was carried out using a questionnaire, and data analysis used SPSS 21 which includes validity, reliability, classical assumption testing, multiple regression analysis, and hypothesis testing. The research results show that digital marketing, brand ambassador, and price have a positive and significant effect on purchasing decisions. Erigo needs to share digital content that better supports its product promotion to increase product purchasing decisions. Erigo needs to increase purchasing interest in product purchasing decisions through brand ambassadors who can further influence consumers. Erigo needs to consider new prices that better suit its products to improve purchasing decisions. The coefficient of determination value of 0.678 indicates that the purchasing decision variable can be explained by digital marketing, brand ambassador and price variables of 67.8% while the remainder is explained by other variables outside the research
Current state and prospects for the development of agriculture in the Vinnytsia region
Authors: Donchak Lesia , Shkvaruk Dina
Published: June 2024

The agriculture of the Vinnytsia region plays an important role in the economy of this region, ensuring food security, employment stability and socio-economic development. The study aims to analyse the current state and peculiarities of the functioning of agriculture in the Vinnytsia region, as well as to identify prospects for the development of this sector of the region's economy. To achieve this goal, the following methods were used: abstract logikal, system-structural, method of analysis and comparison, economic-statistical, tabular, graphical and other methods. The study analyses current trends in agricultural development, covering information up to 2022, as there are currently no official statistics for 2023. It is established that 2022 was a difficult year for the country, as evidenced by the decline in plant production in the region from 2018 to 2022, but at the same time, there was a certain increase in the production of animal products. The study examines the structure of production and efficiency indicators of agriculture, which indicate both positive and negative trends. In particular, the positive side of the dynamics is the increase in the number of agricultural enterprises and the stability of the region's share in the national agricultural production. However, negative trends include a decline in production, a decrease in the profitability of operating activities and other indicators that reflect the impact of economic and technological factors on the industry. The study noted that proper use of fertilisers is essential for increasing land productivity. Several challenges that limit the productivity and sustainability of agricultural development in the region were identified. Climatic conditions, such as temperature and precipitation, environmental, economic and social problems that require an integrated approach to address them. The article substantiates the prospects for agricultural development, namely: optimisation of land use, introduction of modern technologies, support for agriculture and stimulation of ecological agricultural production. Examples of the introduction of modern technologies and innovations in the region's agriculture, including the cultivation of products without the use of chemical fertilisers and pesticides, and the use of precision farming and biogas projects, are considered. Initiatives and programmes to support small and medium-sized enterprises and organic agriculture are also highlighted. These aspects can be used to create development strategies and make informed decisions.
Analysis of the agro-industrial sector of the Kyrgyz Republic
Authors: Sakkaraeva Dzhamilia , Kumashev Murat
Published: June 2024

In the light of global and regional crises, which have become increasingly frequent since the early 2020s, the issues of food security of individual states are particularly acute. For the Kyrgyz Republic, the task of ensuring its own independence from external food suppliers is also highly relevant. The purpose of this study was to conduct a comprehensive analysis of the agro-industrial sector in Kyrgyzstan. In the process of work, statistical analysis of data for 1990-2023 was carried out, as well as empirical research by remote written questionnaire survey of the target audience. As a result, the data on the growing dynamics of the gross product of the Kyrgyz Republic, the role of agrocomplex in the economy of the country were obtained, and the information on the increase in yields of key crops - raw cotton and melons - was confirmed. Separately, the foreign economic balance of the country was considered, which revealed a marked excess of imports to Kyrgyzstan over exports, which is an alarming signal. In the course of the survey conducted among the owners of small and medium-sized farms, information was obtained confirming the need to increase targeted support programmes and provide soft loans for the purchase of agricultural machinery and seeds. Also, as a result of the questionnaire survey, a management problem was identified, where the majority of owners prefer to manage their farms on their own, not trusting professional management. At the same time, almost all respondents confirmed their willingness to introduce additional processing lines in their farms, which would enable them to offer the market a higher-value product. The results of this study are important for the relevant ministries and agencies to ensure technological growth and efficiency of the agro-industrial complex of the Kyrgyz Republic.
Refrigerant Selection in Air Conditioning Systems Considering Thermodynamic, Environmental, and Economic Performance Using the BHARAT-II Multi-Attribute Decision-Making Method
Authors: Rao Ravipudi Venkata , Lakshmi Ravipudi Jaya
Published: June 2024

A simple and effective multi-attribute decision-making method, named as "Best Holistic Adaptable Ranking of Attributes Technique (BHARAT)-II”, to choose the best refrigerant for air conditioning systems is presented. The thermodynamic properties of the refrigerants, and their environmental, and economic performances are also considered for the selection. Two case studies are provided to demonstrate the proposed multi-attribute decision-making method. The first case study addresses the problem of selecting the best refrigerant for residential split air conditioners out of 15 alternative refrigerants considering 12 selection attributes; the second case study addresses the problem of selecting the best refrigerant for automobile air conditioning systems by considering 14 alternative refrigerants and 13 selection attributes. The results of the proposed decision-making method are compared with those of other well-known multi-attribute decision-making methods such as EDAS, TOPSIS, and MOORA. The proposed method is shown to be simple to implement, providing a logical way for allocating weights to the selection attributes and is useful to solve the best alternative refrigerant selection problems of the residential as well as industrial refrigeration and air conditioning.