bluuebunny/crossref_metadata_2025 huggingface dataset:
A novel mouse model of postpartum depression and the neurobiological effects of fast-acting antidepressant treatments
Authors: García-Baos Alba , Ferreres-Álvarez Irene , Gallego-Landin Inés , Puig-Reyné Xavier , Castro-Zavala Adriana , Valverde Olga , Martín-Sánchez Ana
Published: May 2022

postpartum depression (PPD) is a severe psychiatric disorder that affects up to 15% of mothers and impairs mother-infant bonding with devastating consequences on the child development and the mother health. Several studies indicate a possible dysregulation of glutamatergic and GABAergic signalling in the corticolimbic system, as well as a downregulation of the allopregnanolone levels in serum of PPD patients. Although brexanolone, an allopregnanolone-based treatment, has recently emerged as fundamental PPD treatment, there is scarce evidence on its neurobiological action mechanism. Moreover, ketamine appears to be a promising antidepressant treatment preventing PPD, nevertheless whether it might be a more effective than allopregnanolone for some patients remain unknown. Therefore, the present study is aimed to evaluate the depressive-like phenotype of postpartum females undergoing maternal separation with early weaning (MSEW) protocol, as well as to compare the effectiveness of ketamine and allopregnanolone treatments. MSEW dams show increased despair-like behaviour, anhedonia and disrupted maternal behaviour. Moreover, lower allopregnanolone serum levels, reduction of vesicular transporters for GABA (VGAT) and glutamate (VGLUT1) in the infralimbic cortex, as well as decreased hippocampal cellular proliferation are found in MSEW females. As for the antidepressant treatments, both drugs prevent despair-like behaviour, whereas only ketamine reverts anhedonia present in MSEW females. In addition, both treatments induce pro-neurogenic effects in the dorsal hippocampus but only allopregnanolone increases the VGAT and VGLUT1, without altering the excitatory/inhibitory ratio. Altogether, we propose a new mice model that recapitulates the core symptomatology and alterations in glutamatergic and GABAergic systems shown in PPD patients, which allows us to investigate the therapeutic mechanisms of allopregnanolone and ketamine.
Orai3 and Orai1 are essential for CRAC channel function and metabolic reprogramming in B cells
Authors: Emrich Scott M. , Yoast Ryan E. , Zhang Xuexin , Fike Adam J. , Wang Yin-Hu , Bricker Kristen N. , Tao Anthony , Xin Ping , Walter Vonn , Johnson Martin T. , Pathak Trayambak , Straub Adam C. , Feske Stefan , Rahman Ziaur S.M. , Trebak Mohamed
Published: May 2022

The essential role of store-operated Ca2+ entry (SOCE) through Ca2+ release-activated Ca2+ (CRAC) channels in T cells is well established. In contrast, the contribution of individual Orai isoforms to SOCE and their downstream signaling functions in B cells are poorly understood. Here, we demonstrate changes in expression of Orai isoforms in response to B cell activation. We show that Orai3 and Orai1 are essential components of native CRAC channels in B cells and are critical for primary B cell proliferation and survival. The combined loss of Orai1 and Orai3 strongly impairs SOCE, nuclear factor for activated T cells (NFAT) activation, mitochondrial respiration, glycolysis, and the metabolic reprogramming of B cells in response to antigenic stimulation. Our results clarify the molecular composition and cellular functions of SOCE in B lymphocytes.
Barley powdery mildew effector CSEP0162 targets multivesicular body-associated MON1 important for immunity
Authors: Liao Wenlin , Nielsen Mads E. , Pedersen Carsten , Xie Wenjun , Thordal-Christensen Hans
Published: May 2022

Encasements formed around haustoria and biotrophic hyphae as well as hypersensitive reaction (HR) cell death are essential plant immune responses to filamentous pathogens. Here we study a possible reason why these responses are absent in susceptible barley attacked by the powdery mildew fungus. We find that the effector CSEP0162 from this pathogen targets plant MON1, important for fusion of multivesicular bodies to their target membranes. Over-expression of CSEP0162 and silencing of barley MON1 both inhibit encasement formation. We find that the Arabidopsis ecotype No-0 has partial resistance to powdery mildew, and that this is dependent on MON1. Surprisingly, we find the MON1-dependent resistance in No-0 not only include an effective encasement response, but also HR. Similarly, silencing of MON1 in barley also blocked Mla3-mediated HR-based powdery mildew resistance. These data indicate that MON1 is a vital plant immunity component, and we speculate that the barley powdery mildew fungus introduces the effector CSEP0162 to target MON1 and reduce encasement formation and HR.

Highlight

MON1 is essential for MVB fusion to plasma membrane. We find that MON1 also is important for immunity, and that it is targeted by the barley powdery mildew effector CSEP0162.
A glutamine-based single ɑ-helix scaffold to target globular proteins
Authors: Escobedo A. , Piccirillo J. , Aranda J. , Diercks T. , Topal B. , Biesaga M. , Staby L. , Kragelund B. B. , García J. , Millet O. , Orozco M. , Coles M. , Crehuet R. , Salvatella X.
Published: May 2022

The binding of intrinsically disordered proteins to globular ones often requires the folding of motifs into ɑ-helices. These interactions offer opportunities for therapeutic intervention but their modulation with small molecules is challenging because they bury large surfaces. Linear peptides that display the residues that are key for binding can be targeted to globular proteins when they form stable helices, which in most cases requires their chemical modification. Here we present rules to design peptides that fold into single ɑ-helices by instead concatenating glutamine side chain to main chain hydrogen bonds recently discovered in polyglutamine helices. The resulting peptides are uncharged, contain only natural amino acids, and their sequences can be optimized to interact with specific targets. Our results provide design rules to obtain single ɑ-helices for a wide range of applications in protein engineering and drug design.
The crystal structure of baeocystin
Authors: Naeem Marilyn , Sherwood Alexander M. , Chadeayne Andrew R. , Golen James A. , Manke David R.
Published: May 2022

The title compound, baeocystin or 4-phosphoryloxy-N-methyltryptamine {systematic name: 3-[2-(methylazaniumyl)ethyl]-1H-indol-4-yl hydrogen phosphate}, C11H15N2O4P, has a single zwitterionic molecule in the asymmetric unit. The molecule has an intramolecular N—H...O hydrogen bond between the ammonium cation and the hydrophosphate anion. In the crystal, the molecules are linked by N—H...O and O—H...O hydrogen bonds into a three-dimensional network.
Email classification analysis using machine learning techniques
Authors: Iqbal Khalid , Khan Muhammad Shehrayar
Published: May 2022

Purpose

In this digital era, email is the most pervasive form of communication between people. Many users become a victim of spam emails and their data have been exposed.

Design/methodology/approach

Researchers contribute to solving this problem by a focus on advanced machine learning algorithms and improved models for detecting spam emails but there is still a gap in features. To achieve good results, features also play an important role. To evaluate the performance of applied classifiers, 10-fold cross-validation is used.

Findings

The results approve that the spam emails are correctly classified with the accuracy of 98.00% for the Support Vector Machine and 98.06% for the Artificial Neural Network as compared to other applied machine learning classifiers.

Originality/value

In this paper, Point-Biserial correlation is applied to each feature concerning the class label of the University of California Irvine (UCI) spambase email dataset to select the best features. Extensive experiments are conducted on selected features by training the different classifiers.
Workplace spirituality and innovative work behavior: the role of employee flourishing and workplace satisfaction
Authors: Hunsaker William D. , Ding Wenjing
Published: May 2022

Purpose

The purpose of this study is to explore the role of employee flourishing as a mechanism to explain the relationship between workplace spirituality and employees' innovative work behavior (IWB). Furthermore, this study investigates how the relationship between workplace spirituality and innovative behavior is moderated by employees' perceived workplace satisfaction.

Design/methodology/approach

Based on structural equation modeling and hierarchical regression analysis, we conducted a cross-sectional survey of 236 millennial workers in China's service and manufacturing industries.

Findings

The research findings confirmed that workplace spirituality positively predicted the innovative behavior of employees; furthermore, employee flourishing and workplace satisfaction mediated and moderated the relationship between workplace spirituality and employee innovation, respectively.

Practical implications

This study's findings suggest that workplace spirituality unlocks employees' innovative behavior through a heightened sense of flourishing and enhanced sense of workplace satisfaction. Organizations are advised to foster a climate conducive of workplace spirituality by developing mutually aligned values. Moreover, organizations are advised to train leaders on workplace spirituality dimensions and foster workplace practices that facilitate self-reflection, job crafting and team building, as a means of broadening employees' emotional states and workplace satisfaction.

Originality/value

Few studies have examined the mechanisms that shape employees' innovative behavior through workplace spirituality. This study fills several research gaps by extending the theoretical implications of workplace spirituality and employee flourishing, as demonstrated by the multi-faceted role these variables play in motivating employees' innovative behavior among Chinese millennials. Additionally, this study demonstrates that higher levels of workplace satisfaction contribute to higher levels of innovative behavior.
Bibliometric analysis on wellness tourism – citation and co-citation analysis
Authors: Suban Syed Ahamed
Published: May 2022

Purpose

Tourism on wellness is a rapidly expanding segment of the travel industry; nevertheless, it is still in its infancy, and more study research is needed to develop a scientific foundation for health and wellness tourism. The study uses bibliometric indicators like as citations to determine the field structure on wellness tourism from 1998 to 2021, and the VOSviewer software to map the significant trends in wellness tourism (WT) area, to examine the present situation.

Design/methodology/approach

To reach this objective, the theme of “wellness tourism” was searched in the “Scopus” database, and bibliometrics data on the publications were obtained. In total, 414 papers were found during the initial search, which was then narrowed according to the criteria. Using this strategy, the author discovered 386 records, and after removing 4 duplicates and 1 irrelevant document, the refining produced 381 related documents. The most-cited papers, significant authors, co-citation of references, sources and authors were all investigated for the publications related to WT.

Findings

According to this report, research into wellness tourism has increased in recent years. The authors discovered two papers with over 238 “Scopus” citations and a total of 10 studies with 1414 citations. According to Scopus, the document Napieret al.receives 36.5% of citations each year. There were a total of 804 authors who published about WT between 1998 and 2021, with Smith, M, Voigt, c, and Puczkó, L being the most-cited reference authors in the subject. Han h. has the highest index of 56 of all the authors.

Research limitations/implications

The “Scopus” database was used for bibliometric analysis, although the VOSviewer was used exclusively. This considered as a first study to utilize a bibliometric method to address this research gap, identifying the tools, journals, and, most crucially, conceptual subdomains like spa, yoga, therapy, spirituality and trekking that will be significant in future research.

Originality/value

Using a bibliometric analytic approach, this article looked at papers on wellness tourism published between 1998 and 2021. Thus, its goal is to learn more about wellness tourism and to enlighten wellness tourism scholars on the field's structure.
Website stage model for Brazilian wineries: an analysis of presence in digital and mobile media
Authors: Kieling Ana Paula , Tezza Rafael , Vargas Guilherme Lima
Published: May 2022

Purpose

This study aims to expand previous work on website stage models by proposing a new model including a dimension encompassing digital integration and the context of mobile, digital marketing and new technologies. Also, this study aims to classify Brazilian wineries using the stage model proposed and verify if the designated stages influence the wineries’ presence in digital and mobile media.

Design/methodology/approach

Observational research and quantitative content analysis were adopted to examine a sample of winery websites (N = 150) located in different states and regions of Brazil and create a new website stage model. After the new model’s development, the authors conducted a statistic analysis by running a one-factor analysis of variance to assess the influence of the company’s stage in the use of digital media and mobile strategies, as well as its impacts on market development.

Findings

The results suggested a quite mature market regarding website stage position, even though there is still room for growth and technological innovation. Also, the research findings show that there is a positive association between the company’s stage in the use of digital and mobile media strategies. In other words, the more advanced the winery stage, the greater its digital media and mobile presence.

Originality/value

While previous studies attempted to identify wineries’ stages through models, this study presents a new approach by updating the past studies’ stages as well as providing and testing a digital media and mobile dimension. This research contributes to consolidating the Brazilian wine industry position regarding its presence in digital and mobile media, bringing reflections to organizations, society and theory development.
Modelling the group dynamics in the wine industry
Authors: Penagos-Londoño Gabriel , Ruiz-Moreno Felipe , Sellers-Rubio Ricardo
Published: May 2022

Purpose

One of the main difficulties for wine managers is understanding and interpreting how some strategies and company behaviours could affect firms’ performance. This study aims to contribute to improve these concerns by examining the evolution of the competitive wine industry structure over time using the strategic group membership dynamics approach.

Design/methodology/approach

This study empirically analyses a data set spanning the period 2004–2014 to identify the strategic groups in the Spanish wine industry and to model their evolution over time. A time inhomogeneous hidden Markov model (HMM) is used for this purpose.

Findings

Three strategic groups are identified: Young Makers, Quality Lovers and Major Players. Young Makers are small wineries that produce low-quality wines. They are not part of a collective brand – Protected Designation of Origin – and do not invest in marketing campaigns. Quality Lovers produce the highest quality wines but offer a narrow assortment. They invest modestly in advertising, and most of them belong to a Protected Designation of Origin. Major Players produce medium-quality wines, offer a wide assortment and invest heavily in advertising. The groups seem stable over time.

Practical implications

The results show that strategic group analysis can be used to identify and compare patterns of strategic activity within the wine industry, providing a better understanding of the competitive environment.

Originality/value

No previous studies have analysed the competitive structure of the Spanish wine industry. This study delineates the structure of this industry using strategic groups, which is supported by a valid econometric model. Therefore, from a theory base perspective, this study adds new evidence to the stream of research on strategic groups by investigating their evolution over time in the wine industry and the effect of strategic group membership on performance.
Building experience and retention: the influence of principal tenure on teacher retention rates
Authors: Guthery Sarah , Bailes Lauren P.
Published: May 2022

Purpose

Hiring teachers is among principals' most critical work but what remains uncertain is the relationship between a principal's tenure in a school and the rate at which they hire teachers who will stay. Teacher retention and principal experience are key predictors of school stability. This study therefore investigates the influence of principal tenure on the retention rates of teachers they hire over time.

Design/methodology/approach

The authors followed 11,717 Texas principals from 1999 to 2017, and tracked the teachers they hired in each year of their tenure in a school to see if principals became more effective at hiring teachers who stay over time. The authors use regression with fixed effects and find that the longer a principal stayed in a school, the more effective they were at hiring teachers who stay to both three- and five-year benchmarks.

Findings

Principals hire significantly more teachers who persist after they have led their first school for five or more years; however, the average principal in Texas leaves a school after four years thus never realizing those gains. The authors' second main finding indicates that principals who enter an unstable school (less than 69% retention in the two years prior to the principal's arrival) and stay at least five consecutive years, can counteract prior instability.

Originality/value

This study provides initial evidence that principals establish a great deal of building-specific situational expertise that is not easily portable or applicable in a subsequent school placement.
Caring for yourself and for others: team health climate and self-care explain the relationship between health-oriented leadership and exhaustion
Authors: Kaluza Antonia J. , Junker Nina M.
Published: May 2022

Purpose

Health-oriented leadership is an emerging concept that is promising for better understanding how leaders can support employee well-being. However, there is uncertainty about the process through which health-oriented leadership relates to employee well-being. Advancing health-oriented leadership research, this study aims to examine employee self-care and the perceived team health climate as mediating mechanisms.

Design/methodology/approach

The authors conducted a time-lagged study with three measurement points (NT1 = 335, NT2 = 134, NT2 = 113) to test these mechanisms.

Findings

The results show that health-oriented leadership at Time 1 positively relates to employee self-care and perceived team health climate at Time 2, which, in turn, are negatively associated with employee exhaustion at Time 3.

Originality/value

The indirect associations suggest that health-oriented leadership relates to employee well-being via the perceived team health climate and the individuals' self-care. By revealing an important mediating mechanism, this study contributes to the health-oriented leadership literature and can help organizations and leaders improve health promotion in organizations.
Digitalization of the supply chain: transformation factors
Authors: Aamer Ammar , Sahara Chelinka Rafiesta , Al-Awlaqi Mohammed Ali
Published: May 2022

Purpose

There is an increasing interest in the supply chain’s digitalization, yet the topic is still in the preliminary stages of academic research. The academic literature has no consensus and is still limited to research assessing the supply chain’s digitalization of organizations. This study aims to explore the supply chain digitalization drivers to understand the emerging phenomena. More specifically, the authors devised from the literature the most common factors in assessing the readiness in scaling supply chain digitalization.

Design/methodology/approach

This study followed a five-phased systematic literature review (SLR) methodology in this research: designing, analyzing, conducting, writing and assessing the quality of the review. The SLR is beneficial for justifying future research regardless of the complex process that requires dealing with high-level databases, information filtering and relevancies of the content. Through analysis of 347 titles and abstracts and 40 full papers, the authors showed and discussed the supply chain digitalization: transformation factors.

Findings

The results generated three main themes: technology, people and processes. The study also generated ten subthemes/primary drivers for assessing the readiness for supply chain digitalization in organizations: IT infrastructure, cybersecurity systems, digitalization reskilling and upskilling, digitalization culture, top management support, digitalization and innovation strategy, integrated supply chain, digital innovation management, big data management and data analytics and government regulations. The importance of each factor was discussed, and future research agenda was presented.

Research limitations/implications

While the key drivers of the supply chain digitalization were identified, there is still a need to study the statistical correlation to confirm the interrelationships among factors. This study is also limited by the articles available in the databases and content extraction.

Practical implications

This study supports decision-makers in understanding the critical drivers in digitalizing the supply chain. Once these factors are studied and comprehended, managers and decision-makers could better anticipate and allocate the proper resources to embark on the digitalization journey and make informed decisions.

Originality/value

The digitalization of the supply chain is more critical nowadays due to the global disruptions caused by the Coronavirus (COVID-19) pandemic and the surge of organizations moving toward the digital economy. There is a gap between the digital transformation pilot studies and implementation. The themes and factors unearthed in this study will serve as a foundation and guidelines for further theoretical research and practical implications.
Impacts of CSR implementation and channel leadership in a socially responsible supply chain
Authors: Cheng Xinhui , Zhao Weifeng , Zhang Zhichao , Zhang Qing
Published: May 2022

Purpose

Corporate social responsibility (CSR) has now been paid notable attention by a large number of firms. The aim of this paper is to investigate a better way to implement CSR in a socially responsible supply chain with different channel leaderships.

Design/methodology/approach

Started from measuring CSR by purely taking consumer surplus into account, a stylized centralized channel and two different decentralized channels are first developed and examined for equilibria in the socially responsible chain. Furthermore, this paper extends to a socially irresponsible supply chain and a broader practice of CSR by simultaneously incorporating environmental externality and consumer surplus into CSR.

Findings

With the analytical studies, several interesting and important results and managerial insights are clearly revealed. For example, but not limited to, it is found that: (1) Compared with the leader, the follower can effectively implement CSR for a better performance in both pure and socially responsible profits in the decentralized channel; (2) undertaking socially responsible concerns does not always mean reducing the economic profit and conversely being socially irresponsible does not always induce an increase in economic profit for the socially responsible member(s); (3) CSR concern level plays a key role in both the pure and socially responsible profit. An increase in CSR concern level clearly increases the socially responsible profit and poses an ambiguous impact on pure profit depending on different channel leaderships: it decreases the centralized channel in pure profit but increases the pure profit with the decentralized channel under certain conditions; and (4) interestingly, the authors find that decentralization can outperform centralization regarding on both pure and socially responsible channel profits by properly implementing CSR concern levels.

Practical implications

The results derived in this paper provide novel managerial implications to the socially responsible members in terms of pricing decisions, order quantity and CSR practice. In addition, this paper assists the socially responsible supply chain in determining the optimal channel leadership to undertake CSR. That is, decentralization may achieve a better performance than integration under certain market conditions.

Originality/value

To the best of the authors' knowledge, this paper is the first attempt to explore the interactive of the CSR practice and channel leadership in a socially responsible supply chain.
Investigations on the antimicrobial activity of chitosan/PVA nanoparticle loaded nanofibers
Authors: Selvaraj Senthil Kumar , B. Srimathy , S. Sakthivel , B. Senthil Kumar
Published: May 2022

Purpose

In the past decade, the biopolymeric properties of chitosan (CH) have been largely exploited for various applications. This paper aims to study the use of CH in its nanoform, i.e. as nanofibers blended with polyvinyl alcohol (PVA) for various antimicrobial applications in detail. In particular, their ability toward bacterial growth inhibition, in vitro drug release and their biocompatibility toward tissue growth have been investigated in detail.

Design/methodology/approach

Electrospinning technique was adapted for depositing CH/PVA blended nanofilms on the silver foil under optimized conditions of high voltage. Three different concentrations of blended nanofiber samples were prepared and their antimicrobial properties were studied.

Findings

The bead diameter and average diameter of blended nanofibers increase with CH concentration. Antibacterial activity increases as CH concentration increases. Increased hydrophilicity in CH-enriched samples contributes to a higher drug release profile.

Originality/value

To the best of the authors’ knowledge, chick chorioallantoic membrane assay analysis has been carried out for the first time for CH/PVA films which shows that CH/PVA blends are biocompatible. CH after being converted as nanoparticles exhibits higher drug release rate by in vitro method.
Workplace bullying and team performance: the mediating role of team psychological contract breach
Authors: Nabawanuka Hamidah , Ekmekcioglu Emre Burak
Published: May 2022

Purpose

This paper aims to examine the relationship between workplace bullying (WPB) and team performance (TP). And it also attempts to investigate the mediating role of team psychological contract breach (TPCB) in the relationship between WPB and TP.

Design/methodology/approach

Multiple sources and a time-lagged approach were applied at six-week intervals to 64 work teams across 12 different firms in Turkey to test the hypotheses. A linear regression analysis was conducted to evaluate the association between variables.

Findings

The results indicate that WPB leads to negative perceptions of TPCB, which, in turn, have a negative impact on TP.

Research limitations/implications

This study design cannot establish causality, in spite of the fact that the authors used time-lagged data to decrease common method bias.

Practical implications

Managers or team leaders can design activities or programs (i.e. counselling sessions) to promote group cohesiveness, as well as immediately address complaints from team members who feel aggrieved to counteract the negative effects of bullying and reprimand perpetrators; such actions can mitigate perceptions of psychological contract breach.

Originality/value

Few studies have been conducted to test the mediating role of TPCB in the team context. This study stands out as it examines the mediating effect of TPCB in the relationship between WPB and TP. The findings advance the understanding of how WPB could negatively affect TP in a mediation model.
Recognizing the legacy of the TQM Journal: a bibliometric analysis of Scopus indexed publications (2008 - 2021)
Authors: Singh Navjit , Arora Simran
Published: May 2022

Purpose

The purpose of this paper is to examine the trends in research published by the TQM Journal since its indexing in the Scopus database in 2008. The paper intends to offer a bibliometric analysis of the TQM Journal by highlighting the contributions made by the journal through citations, prominent authors, most frequent keywords and publications across geographical regions.

Design/methodology/approach

The study involved the use of descriptive and visual methods to examine the quantitative and qualitative features of the bibliometric data. The authors made use of Biblioshiny using R-Studio and VoS viewer user interfaces to perform various types of bibliometric analysis on the bibliomteric data of the journal extracted from Scopus database (the largest inter-disciplinary database in social sciences).

Findings

With 85% of cited documents having a total 12,079 citations, the TQM Journal is one of the most reputed and impactful journals in the field of performance, integrated management system total quality management and allied concepts. The publications in the TQM Journal have cited many top-rated journals relevant to the domain. Maximum contributions in TQM Journal are submitted by authors from Italy, India and UK. Major submissions made to TQM Journal have focused on the quality concepts relevant to production and manufacturing sector in particular. In this regard, the TQM Journal has a very bright scope in covering the diverse and latest trends across industries especially during pandemic and changes happening thereof. The contributions of the editorial team along with authors and reviewers are unmatchable in making the reputation of the TQM Journal.

Originality/value

To the best of knowledge of the authors, this is going to be first bibliometric study ever conducted on the TQM Journal on documents published in Scopus database. The work carried out is unique, as it is an attempt by authors to comprehend the legacy of the TQM Journal through bibliometric data and showcase the past trends and explore future directions for the TQM Journal.
Beyond single host, single parasite interactions: Quantifying competence for complete multi‐host, multi‐parasite communities
Authors: Stewart Merrill Tara E. , Calhoun Dana M. , Johnson Pieter T. J.
Published: May 2022

Understanding parasite transmission in communities requires knowledge of each species' capacity to support transmission. This property, ‘competence’, is a critical currency for modelling transmission under community change and for testing diversity–disease theory. Despite the central role of competence in disease ecology, we lack a clear understanding of the factors that generate competence and drive its variation.

We developed novel conceptual and quantitative approaches to systematically quantify competence for a multi‐host, multi‐parasite community. We applied our framework to an extensive dataset: five amphibian host species exposed to four parasitic trematode species across five ecologically realistic exposure doses. Together, this experimental design captured 20 host–parasite interactions while integrating important information on variation in parasite exposure. Using experimental infection assays, we measured multiple components of the infection process and combined them to produce competence estimates for each interaction.

With directly estimated competence values, we asked which components of the infection process best explained variation in competence: barrier resistance (the initial fraction of administered parasites blocked from infecting a host), internal clearance (the fraction of established parasites lost over time) or pre‐transmission mortality (the probability of host death prior to transmission). We found that variation in competence among the 20 interactions was best explained by differences in barrier resistance and pre‐transmission mortality, underscoring the importance of host resistance and parasite pathogenicity in shaping competence.

We also produced dose‐integrated estimates of competence that incorporated natural variation in exposure to address questions on the basis and extent of variation in competence. We found strong signals that host species identity shaped competence variation (as opposed to parasite species identity). While variation in infection outcomes across hosts, parasites, individuals and doses was considerable, individual heterogeneity was limited compared to among‐species differences. This finding highlights the robustness of our competence estimates and suggests that species‐level values may be strong predictors for community‐level transmission in natural systems.

Competence emerges from distinct underlying processes and can have strong species‐level characteristics; thus, this property has great potential for linking mechanisms of infection to epidemiological patterns.

Read the free Plain Language Summary for this article on the Journal blog.
The role of leaf cutting and fire on extrafloral nectaries and nectar production in Stryphnodendron adstringens (Fabaceae, Mimosoideae) plants
Authors: Delgado Marina Neves , de Morais Helena Castanheira , Rossatto Davi Rodrigo
Published: May 2022

Herbivory pressure is an important ecological aspect to determine quantitative variation in plant defenses, such as the number of extrafloral nectaries (EFNs) and their nectar amount and quality. Extrafloral nectaries can attract ants, which can be considered a type of induced plant defense. Besides, plants tend to invest more in defense when they are more vulnerable to herbivores. Therefore, we aimed to elucidate if Stryphnodendron adstringens (Fabaceae), a common Cerrado tree species, when subjected to damage (by manual leaf cutting and experimental fire) would produce a greater number of EFNs and changes its nectar quality on newly produced leaves in comparison with plants not subjected to these treatments. Leaf damage was performed artificially directly on the plant branches and at the entire plant canopy (by means of scissors or fire events). Extrafloral nectary density was higher in new leaves produced after the treatment application (artificial herbivory and fire) in comparison with plants under control treatment. The amount of nectar was also higher under treatments in comparison with control, with a significant change on nectar quality in plants subjected to the treatments of artificial herbivory. The results provided support for the hypothesis that EFNs are an inducible defensive strategy in S. adstringens, confirming the existence of phenotypic plasticity given environmental pressures.
Consideration of racism experiences in the implementation of trauma‐focused therapy in primary care
Authors: McCuistian Caravella , Kimball Sarah L. , Buitron de la Vega Pablo , Godfrey Laura B. , Fortuna Lisa R. , Valentine Sarah E.
Published: May 2022

Objective

To understand providers' perceptions of how a patient's experience of racism may impact the successful implementation of a brief posttraumatic stress disorder (PTSD) treatment in the safety net integrated primary care setting. To conduct a developmental formative evaluation prior to a hybrid type I effectiveness‐implementation trial.

Data Sources and Study Setting

From October 2020 to January 2021, in‐depth qualitative interviews were conducted with integrated primary care stakeholders (N = 27) at the largest safety net hospital in New England, where 82% of patients identify as racial or ethnic minorities.

Study Design

Interviews with clinical stakeholders were used to (a) contextualize current patient and provider experiences and responses to racism, (b) consider how racism may impact PTSD treatment implementation, (c) gather recommendations for potential augmentation to the proposed PTSD treatment (e.g., culturally responsive delivery, cultural adaptation), and (d) gather recommendations for how to shift the integrated primary care practice to an antiracist framework.

Data Collection/Extraction Methods

Interview data were gathered using remote data collection methods (video conferencing). Participants were hospital employees, including psychologists, social workers, primary care physicians, community health workers, administrators, and operations managers. We used conventional content analysis.

Principal Findings

Clinical stakeholders acknowledged the impact of racism, including racial stress and trauma, on patient engagement and noted the potential need to adapt PTSD treatments to enhance engagement. Clinical stakeholders also characterized the harms of racism on patients and providers and provided recommendations such as changes to staff training and hiring practices, examination of racist policies, and increases in support for providers of color.

Conclusions

This study contextualizes providers' perceptions of racism in the integrated primary care practice and provides some suggestions for shifting to an antiracist framework. Our findings also highlight how racism in health care may be a PTSD treatment implementation barrier.
Profile of explosives's use in ATMs/cash safes robberies in Brazil
Authors: Logrado Lúcio Paulo Lima , Silva Marielly Nascimento , Laboissiere João Carlos Ambrósio , Braga Jez Willian Batista
Published: May 2022

This retrospective study reports data obtained by the Federal Police's National Institute of Criminalistics (INC‐PF) relating to chemical analysis aimed at identifying explosives used in Automated teller machines (ATMs)/cash safes robberies between 2014 and 2020 in Brazil. 93 Real cases were studied and, based on the analysis carried out on the materials related to these cases, focusing on the type of explosive used, the following distribution profile was obtained: I) explosive mixtures based on chlorates and/or perchlorates (53%); explosive emulsion (22%); black gunpowder (13%); negative/inconclusive (11%) and organic ‐ pentaerythritol tetranitrate (PETN) (1%). These results can contribute to investigations related to diversion/loss of explosives for criminal purposes, indicating, for example, through relationships between prevalence in the use of a certain type of explosive with a certain location, its possible origin (mining industry, explosive industries, fireworks factories, among others). The profile observed in the results can guide the selection of explosives to be studied in future research, as the possibilities are vast. Furthermore, despite the expressive number of occurrences in Brazil in the period of interest of this study, only a small fraction of samples was sent to the forensic chemistry laboratory to identify the explosive involved, which suggests that expanding chemical analysis should be encouraged in this field. In combination with an increase in professional training and collaboration trials between the laboratories, these activities can improve the chemical explosive's profile in Brazil, enabling the search for correlations between occurrences and contributing to the growth and development of this area.
The Siamese rice trade during the interwar years: Trade pattern, crisis and business survival
Authors: Chutipongpisit Apicha
Published: May 2022

This article recounts the story of the Siamese rice trade during the interwar years. Many previous studies tend to focus on the Great Depression in 1929 and the decline in the Siamese rice trade. However, export statistics show that Siam continued to export large volumes of rice during this period. This article examines the Siamese rice export patterns and highlights how instrumental Western and Japanese firms were in determining the destinations to which the rice was shipped. It also explores business strategies in response to interwar market conditions that helped the Siamese rice trade survive.
Hyaluronic acid in the treatment of dry eye disease
Authors: Hynnekleiv Leif , Magno Morten , Vernhardsdottir Ragnheidur R. , Moschowits Emily , Tønseth Kim Alexander , Dartt Darlene A. , Vehof Jelle , Utheim Tor P.
Published: May 2022

Dry eye disease (DED) is a highly prevalent and debilitating condition affecting several hundred million people worldwide. Hyaluronic acid (HA) is a naturally occurring glycosaminoglycan commonly used in the treatment of DED. This review aims to critically evaluate the literature on the safety and efficacy of artificial tears containing HA used in DED treatment. Literature searches were conducted in PubMed, including MEDLINE, and in EmbaseviaOvid with the search term: “(hyaluronic acid OR hyaluronan OR hyaluronate) AND (dry eye OR sicca)”. A total of 53 clinical trials are included in this review, including eight placebo‐controlled trials. Hyaluronic acid concentrations ranged from 0.1% to 0.4%. Studies lasted up to 3 months. A broad spectrum of DED types and severities was represented in the reviewed literature. No major complications or adverse events were reported. Artificial tears containing 0.1% to 0.4% HA were effective at improving both signs and symptoms of DED. Two major gaps in the literature have been identified: 1. no study investigated the ideal drop frequency for HA‐containing eyedrops, and 2. insufficient evidence was presented to recommend any specific HA formulation over another. Future investigations assessing the optimal drop frequency for different concentrations and molecular weights of HA, different drop formulations, including tonicity, and accounting for DED severity and aetiology are essential for an evidence‐based, individualized approach to DED treatment.
Intravitreal and subretinal syngeneic bone marrow mononuclear stem cell transplantation improves photoreceptor survival but does not ameliorate retinal function in two rat models of retinal degeneration
Authors: Di Pierdomenico Johnny , Gallego‐Ortega Alejandro , Martínez‐Vacas Ana , García‐Bernal David , Vidal‐Sanz Manuel , Villegas‐Pérez María P. , García‐Ayuso Diego
Published: May 2022

Purpose

To study and compare effects of syngeneic bone marrow mononuclear stem cells (BM‐MNCs) transplants on inherited retinal degeneration in two animal models with different etiologies: the RCS and the P23H‐1 rats. To compare the safety and efficacy of two methods of intraocular delivery: subretinal and/or intravitreal.

Methods

A suspension of BM‐MNCs was injected subretinally or intravitreally in the left eyes of P23H‐1 and RCS rats at post‐natal day (P) 21. At different survival intervals after the injection: 7, 15, 30 or 60 days, the retinas were cross‐sectioned, and photoreceptor survival and glial cell responses were investigated using immunodetection of cones (anti‐cone arrestin), synaptic connections (anti‐bassoon), microglia (anti‐Iba‐1), astrocytes and Müller cells (anti‐GFAP). Electroretinographic function was also assessed longitudinally.

Results

Intravitreal injections (IVIs) or subretinal injections (SRIs) of BM‐MNCs did not produce adverse effects. The transplanted cells survived for up to 15 days but did not penetrate the retina. Both IVIs and SRIs increased photoreceptor survival, decreased synaptic degeneration and glial fibrillary acidic protein (GFAP) expression in Müller cells but did not modify microglial cell activation and migration or the electroretinographic responses.

Conclusions

Intravitreal and subretinal syngeneic BM‐MNCs transplantation decreases photoreceptor degeneration and shows anti‐gliotic effects on Müller cells but does not ameliorate retinal function. Moreover, syngeneic BM‐MNCs transplants are more effective than the xenotransplants of these cells. BM‐MNC transplantation has potential therapeutic effects that merit further investigation.
Development of a tool to assess the methodological quality of studies reporting on archaeologically excavated human skeletons: An international Delphi study
Authors: Rajbhoj Amit Arvind , Speyer Renée , Crevecoeur Isabelle , Begnoni Giacomo , Willems Guy , Cadenas de Llano‐Pérula Maria
Published: May 2022

Methodological bias can directly affect the interpretation of research data. Studies reporting on excavated skeletons represent a valuable source of information in medicine, dentistry, archaeology and anthropology, and forensic sciences. However, these studies represent a specific setting with their own methodology, for which no quality assessment tool is available. The aim was to develop a critical appraisal tool to assess the methodological quality of studies reporting on archaeologically excavated human skeletons. An international Delphi study was therefore conducted to support item generation and ensure content validity for a new tool. Experts from the following domains were consulted: dentistry, forensic sciences, archaeology and anthropology, general medicine, epidemiology, and statistics. Participants judged the relevance and comprehensiveness of items retrieved from the literature. Consensus was predefined as 75% agreement between experts, and achieved within two Delphi rounds. As a result, 44 and 32 participants completed the first and second Delphi rounds, respectively, achieving consensus on 17 items. This research provides the first evidence‐based tool for the methodological assessment of studies reporting on archaeologically excavated skeletons. Clinicians and researchers can use this tool for critical appraisal of studies or when performing systematic reviews. Future research will focus on psychometric testing of the newly developed tool.
‘Nothing new under the sun’: Rethinking recycling in the past– Editorial
Authors: Sainsbury Victoria A. , Liu Ruiliang
Published: May 2022

Editorial for the Special Issue of Archaeometry ‘Tackling Recycling in the Past’. The practice of recycling has undoubtedly become one of the most important strategies to build a long‐term sustainable society in the modern world. However, both the perception and practice of recycling can be traced back to prehistory through various archaeological records. Objects made of stone, jade, mortar, textiles, pottery and bones display evidence of physical reshaping and repair, as do objects of metal and glass. Metal and glass, moreover, are materials which can be melted and recast, freeing ancient people from the limitations of the physical form of the original object. Illustrating and understanding patterns of recycling and the underlying social organization can significantly advance our knowledge of ancient people, their economic, political and cultural motivations for recycling, as well as the broad interaction between the social and material world. Though the issue of recycling is not novel in the discussions and debates of the archaeological circle, new theoretical frameworks, methodologies and archaeometric data encourage us to revisit the topic in this special issue. In this editorial, we consider what recycling means in the past, and why these papers are vital.