bluuebunny/crossref_metadata_2025 huggingface dataset:
Heart Disease Prediction System Using Random Forest Technique
Authors: Babu G. Harinadha , Jayasree Gunda , Ashika Chattu , Ahalya Vajja , Niroopa Katta Asha
Published: January 2023

Abstract: Heart disease prediction and diagnosis have always been challenging tasks for medical experts. Hospitals and other medical facilities offer pricey procedures and treatments for cardiac diseases. As a result, being able to people all around the world can take the necessary actions to treat cardiac disease before it becomes severe if it is discovered in its early stages. The main causes of heart disease, a severe problem in recent years, are drinking alcohol, smoking cigarettes, and not exercising. A significant amount of data generated over time by the health care sector has allowed machine learning to offer efficient results in decision-making and prediction. We attempt to predict probable heart conditions in patients using machine learning approaches. In this project, we compare various classifiers, including decision trees, Naive Bayes, logistic regression, SVM, and random forests. We also suggest an ensemble classifier, which performs hybrid classification by combining the best features of both strong and weak classifiers and can handle large amounts of training and validation samples. We contrast already-in-use classifiers with others that have been proposed, such as Ada-boost and XGboost, which can offer higher accuracy. The main advantages of heart disease prediction using machine learning are that it manages the largest (enormous) quantity of data using the random forest algorithm and feature selection, as well as reducing the complexity of the doctors' time and being cost- and patient-friendly.
When Soldiers Open Fire on a Protest. Massacres in Riga, Tallinn, and Minsk in 1905
Authors:   University of Tartu, Kann Lauri
Published: January 2023

his article compares three of the most horrific shootings against protesters in Riga, Tallinn, and Minsk during the Revolution of 1905. The aim of this comparison is to find similarities in these events that would reflect the tsarist authorities’ principles on the use of deadly force against protesters in general. The article also claims that shootings against protesters in the Western borderlands of the Russian Empire all together had more influence on radicalising the situation than it has been acknowledged in studies that give a general perspective of the Revolution of 1905.
The Principle of Equality Before the Court in the Systemic Unity of the Instances of the Judicial System of Russia
Authors:   North-West Institute of Management of the Russian Academy of National Economy and Public Administration under the President of the Russian Federation, Mayboroda Viktor A. , Shukshin Sergey I. ,   Saint Petersburg State Institute of Culture
Published: January 2023

The article considers the principle of equality of all before the court. Based on the relationship between the possibilities for ensuring procedural equality in the courts of fi rst and appellate instances, the subsequent assessment of the legality of a judicial act in the courts of cassation and at the stage of supervisory proceedings, the authors came to the conclusion that the existing means of ensuring equality through economic instruments does not fully correspond to the goals of legal proceedings. In this regard, procedural equality between economically strong subjects, economically self-suffi cient subjects and other participants in legal proceedings should be ensured by granting a different scope of procedural rights to persons in a worse economic situation relative to the opposite side.
Expect the unexpected: Four hypotheses to explain unexpected critical zone symmetry in hillslopes with opposing aspect
Authors: Donaldson Amanda Marie , Zimmer Margaret Ann , Huang Mong-Han , Johnson Kerri N , Hudson-Rasmussen Berit , Finnegan Noah Joseph , Barling Nerissa , Callahan Russell
Published: January 2023

The structure of the critical zone is a product of feedbacks between
hydrologic, climatic, biotic, and chemical processes. Ample research
within snow-dominated systems has shown that aspect-dependent solar
radiation inputs can produce striking differences in vegetation
composition, topography, and soil depth between opposing hillslopes.
However, more research is needed to understand the role of microclimates
on critical zone development within rain-dominated systems, especially
below the soil and into weathered bedrock. To address this need, we
characterized the critical zone of a north-facing and south-facing slope
within a first-order headwater catchment located in central coastal
California. We combined terrain analysis of vegetation distribution and
topography with field-based soil pit characterization, geophysical
surveys and hydrologic measurements between slope-aspects. We observed
thicker soil profiles, higher shallow soil moisture, and denser
vegetation on north facing slopes, which matched previously documented
observations in snow-dominated sites. However, average topographic
gradient and saprolite thickness were uniform across our study
hillslopes, which did not match common observations from the literature.
These results suggest dominant processes for critical zone evolution are
not necessarily transferable across regions. Thus, there is a continued
need to expand critical zone research, especially in rain-dominated
systems. Here, we present four non-exclusive, testable hypotheses of
mechanisms that may explain these unexpected similarities in slope and
saprolite thickness between hillslopes with opposing aspects.
Specifically, we propose both past and present ecohydrologic processes
must be taken into account to understand what shaped the present day
critical zone.
Lexicon and attention based handwritten text recognition system
Authors: Kumari Lalita , Singh Sukhdeep , Rathore Vaibhav Varish Singh , Sharma Anuj
Published: January 2023

The handwritten text recognition problem is widely studied by the researchers of computer vision community due to its scope of improvement and applicability to daily lives. It is a sub-domain of pattern recognition. Due to advancement of computational power of computers since last few decades neural networks based systems heavily contributed towards providing the state-of-the-art handwritten text recognizers. In the same direction, we have taken two state-of-the art neural networks systems and merged the attention mechanism with it. The attention technique has been widely used in the domain of neural machine translations and automatic speech recognition and now is being implemented in text recognition domain. In this study, we are able to achieve 4.15% character error rate and 9.72% word error rate on IAM dataset, 7.07% character error rate and 16.14% word error rate on GW dataset after merging the attention and word beam search decoder with existing Flor et al. architecture. To analyse further, we have also used system similar to Shi et al. neural network system with greedy decoder and observed 23.27% improvement in character error rate from the base model.
Ten-Year Prospective Follow-Up of Institutionalized Patients With Diabetes in a Long-Term Care Home
Authors: Vergely Nathalie
Published: January 2023

Clinical practice recommendations advise individualizing diabetes treatment for elderly people, especially those living in long-term care facilities. Elderly patients face one of two main risks: either excessive treatment leading to hypoglycemia or insufficient treatment leading to progression of complications and excess mortality. This article describes a 10-year prospective observational study of people with diabetes in a long-term care home to determine the effect of routine glucose monitoring and monthly evaluation by a diabetes specialist with a goal of improving A1C. Its findings suggest that minimal glucose monitoring and monthly medical follow-up can optimize patient outcomes and help to maintain quality of life without over-medicalization of older people with diabetes in institutional settings.
Association Between Change in A1C and Use of Professional Continuous Glucose Monitoring in Adults With Type 2 Diabetes on Noninsulin Therapies: A Real-World Evidence Study
Authors: Nemlekar Poorva M. , Hannah Katia L. , Norman Gregory J.
Published: January 2023

This retrospective analysis examined the association between change in A1C and professional continuous glucose monitoring (p-CGM) use in patients with type 2 diabetes and poor glycemic control who were not using insulin. Data from 15,481 eligible patients (p-CGM users n = 707 and p-CGM nonusers n = 14,774) showed a greater decrease in A1C from baseline to the end of follow-up for p-CGM users, and differences favored p-CGM users regardless of whether they started insulin therapy during the follow-up period. These findings suggest that people with type 2 diabetes who have poor glycemic control using multiple noninsulin therapies may benefit from p-CGM, which can reduce A1C over a 6-month period compared with usual care.
Aplikasi HijaiyahKu Berbasis Android
Authors: Ulum Muhamad Bahrul , Azizah Anik Hanifatul , Sandfreni Sandfreni
Published: January 2023

Early introduction to hijaiyah letter to children is important, for it is the basic of Al-Qurâ€™an reading as Moslemâ€™s guidance in life. Al-Qurâ€™an reading learning method is often given in direct teaching by teachers with the help of books introducing and teaching hijaiyah letters. Introducing hijaiyah letters to children requires effective and engaging teaching method, one of them is by teaching by playing. Using games as medium will create fun atmosphere for an interactive teaching process. This Android based introducing method utilized prototype method, from research stage to application test stage. The result of this application design is an application that may help ease children in learning hijaiyah letters. With this application, children can learn about hijaiyah letters while playing, and train their memories and concentrations with the help of smartphone technology.
Prediction of 6 Personality Characters (HEXACO) from Social Media using Random Forest Classifier and Particle Swarm Optimization
Authors: Ramadhan Iksan
Published: January 2023

The importance of personality assessment is required in determining whether an individual can support a job, or which position is suitable and in accordance with his personality. The personality model that is often used is the Myer Brigs Type Indicator, but the model is considered inappropriate for use because the model is too dichotomous in defining one's personality. Unlike the HEXACO personality model, the model provides a numerical assessment of each personality trait. In determining an individual's personality, it can be done by utilizing one's writing using the classification algorithm model. In the test, the data collected previously was classified according to its target to get the results in the form of personality classifications. Testing is done using the PSO algorithm so that the results obtained have a high level of accuracy, equal to 0.9 (90%). The use of PSO algorithm can help to get high accuracy results in the prediction process because the search for parameter values in the prediction model is done automatically.
STRUKTUR NASKAH DRAMA ROH KARYA WISRAN HADI
Authors: Lady Amara Demylia
Published: January 2023

The structural approach is an initial approach in a literary research. The purpose of this research is to describe the structural elements and describe the relationship between any elements in the drama script Roh by Wisran Hadi. The source of this research is the drama script Roh by Wisran Hadi written in June 1998 in Pagaruyung, West Sumatra. The script of this play has four acts with 29 pages. The drama script Roh is one of the best scripts by Wisran Hadi and won the 2nd place award in the 2003 DKJ competition. The drama script Roh by Wisran Hadi was published in the Sobrat drama script collection. Published by PT. Grasindo Jakarta 2003. The results of this study are in accordance with the initial objectives, the process of obtaining data is carried out through various stages, starting from the stage of recording data, classifying data and analyzing data. This research was conducted to prove that within the intrinsic elements of Wisran Hadi's dramae Roh, there is a concrete and significant relationship so that a literary work can be enjoyed in every verse of the written word
VOCATIVE USE OF PEOPLE'S NAMES AND FAMILY RELATIONSHIPS IN SUNDANESE CONVERSATION IN THREE INTERNET SITES IN 2022
Authors: Wahya Wahya
Published: January 2023

Sundanese is a local language spoken by ethnic Sundanese Indonesian. Like any other language in the world, Sundanese also has language devices called vocatives to call addresses by speakers in a conversation. This paper explains the vocative, including the forms, which are the level of speech to show the social relations between speakers and addresses. The method used to collect the data is an observation method. The data analysis used is a distributional method with a sociolinguistic approach. From twenty-six data, there are sixteen people-name vocatives and ten family-relation vocatives. Of the sixteen people-name vocatives, six vocatives are in full-nickname form, namely Giri (1), Gilang (1), Lia (3), and Ani (1); and ten vocatives are in partial-nickname form, namely Lang (2) Nit (2), Tir (4), and Put (4). Meanwhile, ten family-relation vocatives consist of nine partial Sundanese-honorific forms, namely Kang (6), Neng (2), and Ceu (1), and one complete Sundanese-honorific form, namely Si Aa. Furthermore, from sixteen people-name vocatives, thirteen vocatives are used to show respect to others and three others to show familiar code. Meanwhile, all the family-relation vocatives are used to respect others. Hence, people-name vocatives are used to maintain social relationships on friendships. Meanwhile, family-relation vocatives are used to create new friendships.
Digital Transformation and Financing Constraints: Empirical Research on Listed Companies in China
Authors: Li Guiqian
Published: January 2023

With the development of digital technology advancement and digital transformation proceeding, the relationship between the degree of digital transformation and financing constraints of Chinese listed companies deserves to be further explored. This research explores the effect of digital transformation and financing constraints through empirical research, taking the Chinese listed companies from the year 2013 to 2020 as the research sample. The research reveals that there is a significant negative effect between digital transformation and financing constraints.
Analysis of Quality Control of Chocolate Production Process at CAU Chocolates Bali
Authors: Saputra I Kadek Dwi Wahyu , Purnawati Ni Ketut
Published: January 2023

The products produced by the company must comply with the quality standards expected by the customer, for that a strict quality control system is needed. This study aims to analyze the quality control activities of the chocolate production process at PT. CAU Chocolates Bali is already optimal. This research was conducted at PT. CAU Chocolates Bali is located at Jalan Marga-Apuan, Cau, Marga, Tabanan Regency, Bali. This research uses descriptive research method with saturated sampling technique in sampling the product to be tested. The data used in this study is data on the number of chocolate product defects in the period May to June 2022. The data analysis technique used in this study is Statistical Quality Control, namely with p control chart diagrams and cause-and-effect diagrams as well as quality cost analysis. The results of the quality cost analysis show that the production process quality control activities carried out by PT. CAU Chocolates Bali is still not optimal, because even though the level of damage that occurs is still within the control limit or is still between the upper limit (UCL) and the lower limit (LCL), the actual total cost of quality charged to the company is still greater than total cost of optimal quality.
Single Maxillary Complete Denture: Particularities and Treatment Considerations
Authors: Bounaouara Rahma , Tayari Oumaima , Mansour Lamia , Jaouadi Jamila
Published: January 2023

The prosthetic restoration of a unimaxillary edentulous arch is a complex treatment and a challenging clinical situation. This type of edentulous is more frequently encountered in the maxilla than in the mandible. It is opposed to a natural dentition, that can be the origin of aesthetic, occlusal and biological problems affecting the integration of the future prosthesis. Achieving harmonious occlusal plane and obtaining occlusal balance and aesthetic satisfaction of the patient are the principal objectives of the treatment. The practitioner must perform a reasoned analysis of the clinical case, detect the existing difficulties, and establish a strategy of adapted treatment. This article aim’s is to present, through two clinical cases, the particularities of this type of edentulism, and the therapeutic approach for the management of the aesthetic and functional difficulties.
Omani Students’ Satisfaction with Independent Learning Tools during Covid-19
Authors: Chinnathambi Kodhandaraman , Said Bani Orabah Salim , Sarah Rani Siti , Anandan Latha
Published: January 2023

Omani students were introduced to Independent Learning Tools, such as MyELT, Moodle, and MS Teams, during the Covid-19 pandemic. They used these tools for their study throughout the pandemic. Hence, this research investigated how satisfied were Omani students with independent learning tools during Covid-19. This study is significant because it has pedagogical implications for all the stakeholders, such as teachers, students, and policymakers. This study adopted a quantitative research method. A self-prepared questionnaire was distributed to students for data collection. Study participants were students from Level one, Level two, Level three, and Level four of the General Foundation Program in the English Language Center at the University of Technology and Applied Sciences-Ibra, Oman. About 227 (N=227) students participated in the survey. Study findings suggest that students’ satisfaction with independent learning tools is above average. Conducting similar research studies in other Higher Educational Institutions in Oman will help make and sustain policy decisions.
Pemeranan Tokoh Adang Dalam Naskah Titik-Titik Hitam Karya Nasjah Djamin
Authors: Kurnianto Danang , Bahar Mahdi , Komadri Muhammad
Published: January 2023

Naskah Titik-titik Hitam karya Nasjah Djamin merupakan Naskah bergaya realisme. Tema besar yang diangkat merupakan tema keseharian. Pemeran menggunakan metode Boleslavsky untuk memerankan tokoh Adang dalam Naskah Titik-titik Hitam karya Nasjah Djamin. Metode Boleslavsky digunakan guna tercapinya pemeranan yang diinginkan. Tokoh Adang yang berada di dalam naskah bergaya realisme ini diwujudkan dengan konsep pemeranan yang natural. Hasil dari penerapan metode akting Boleslavsky adalah terwujudnya tokoh Adang yang tegas dan rapuh dengan konsep akting yang natural. Adapun kesimpulan dalam proses pemeranan ini adalah bahwa metode akting Boleslavsky mampu mendukung pemeran dalam mewujudkan tokoh Adang dalam Naskah Titik-titik Hitam karya Nasjah Djamin. Pemeran tentunnya mengalami kendala pada proses pencarian tokoh Adang, dikarenakan adanya perbedaan karakter dari pemeran terhadap tokoh Adang. Dalam menanggapi kendala pada proses pencarian tokoh, pemeran melatih tiga elemen penting seorang aktor yaitu: Olah vokal, olah tubuh dan olah rasa. Pemeranan tokoh Adang ditujukan untuk menerapkan metode akting Boleslasvky, dengan konsep akting yang natural.Kata Kunci: Titik-titik Hitam, Realisme, Boleslvsky, Pemeranan
Penerapan Ornamen Melayu Deli Pada Light Box Dengan Teknik Paper Cutting
Authors: Panmayu Zhurina , Mirwa Tetty
Published: January 2023

Seiring berkembangnya zaman, masyarakat modern mulai meninggalkan ornamen tradisional seperti ornamen Melayu Deli. Perlunya memandang kembali budaya tradisional agar nilai-nilai luhur masyarakat Melayu Deli tidak hilang begitu saja. Sejauh ini, cara yang dilakukan masyarakat untuk melestarikan ornamen masih monoton. Proses penciptaan karya seni menurut Graham Wallas dalam buku The Art Thought (Djelantik, 2001: 64) terdiri dari: persiapan (preparation), inkubasi (incubation) inspirasi/ ilham (inspiration), elaborasi/ perluasan/ pemantapan (elaboration). Motif yang dipakai pada pembuatan karya light box ini adalah motif Roda Sula, motif Awan Semayang, motif Semut Beriring, motif Pelana Kuda Kencana, motif Itik Pulang Petang, Pucuk Kacang, motif Bunga Hutan, motif Tapuk Pinang, motif Terali Jantung, dan motif Terali Biola. Diharapkan penelitian ini dapat menjadi inspirasi dalam mengenalkan ornamen Melayu Deli dan dapat menjadi referensi untuk melakukan jenis penelitian yang sama mengenai pelestarian ornamen pada karya seni light box.Kata Kunci: Light Box, Paper cutting, Ornamen
Penciptaan Desain Tote Bag Menggunakan AI Draw dan Teknik Digital Printing sebagai Cenderamata Kota Medan
Authors: Siregar Agustian , Zulkifli Zulkifli
Published: January 2023

Pengerajin tote bag di kota Medan pada saat ini tidak banyak yang menggunakan konsep desain ikon kota Medan. Hal ini menjadikan sepinya distribusi produk tote bag di outlet penjualan oleh-oleh kota Medan. Karya tulis ini bertujuan untuk menganalsis bagaimanakah penciptaan desain tote bag menggunakan aplikasi AI Draw atau Adobe Illustrator Draw dan teknik digital printing, serta mengetahui kualitas produk hasil penciptaan desain tote bag sebagai cenderamata kota Medan. Penciptaan dan penyajian seni ini menggunakan metode yang dijelaskan oleh Gustami yang di dalamnya terdapat tiga tahap penciptaan karya seni yaitu Eksplorasi, Perancangan, dan Perwujudan. Adapun langkah yang diambil dalam proses penciptaan 10 karya desain tote bag sebagai cenderamata kota Medan adalah perancangan konsep desain, pembuatan sketsa (tracing), penerapan warna pada desain (coloring), pemberian detail warna pada desain, finishing desain, dan finishing karya. Kualitas hasil penciptaan desain tote bag sebagai cenderamata kota Medan dinilai oleh 3 orang penilai yang merupakan ahli bidang akademik seni rupa. Kualitas hasil yang diperoleh pada 10 karya desain tote bag dengan memerhatikan penerapan unsur desain dan prinsip seni rupa, aspek penciptaan desain berupa konsep yang merupakan ikon-ikon yang ada di kota Medan, bentuk objek yang realis dan deformatif, hingga harmonisasi warna dan komposisi warna yang sesuai dengan objek. Dari ketiga penilai secara keseluruhan berada dalam kategori B (Baik) dengan jumlah skor = 271, dan skor rata-rata = 4,5.Kata Kunci: Tote bag, Cenderamata, digital printing
Sobre los materiales del herbario de Félix Haenseler para la tipificación de los nombres Abies pinsapo Boiss. (Pinaceae) y Staehelina baetica DC. (Asteraceae)
Authors: Ferrer Gallego Pedro Pablo , Laguna Emilio , Pérez Latorre Anrdés Vicente , Cabezudo Baltasar
Published: January 2023

El herbario de Félix Haenseler representó una relevante colección para la descripción de algunas plantas importantes para la flora vascular andaluza. La existencia de un espécimen duplicado de un material original de Haensler de Staehelina baetica DC. en el herbario de Candolle en Ginebra ha permitido la designación de un lectotipo para este nombre. También, la localización del material de herbario de Haenseler que fue citado por Boissier en el protólogo de Abies pinsapo Boiss. que fue cedido a través de Pablo Prolongo a la Sociedad Malagueña de Ciencias, representaría un cambio en el actual tipo nomenclatural para el pinsapo.
Psychological implications of humane endings on the veterinary profession
Authors: Kollias Nathaniel S. , Strand Elizabeth B. , Kogan Lori R. , Houlihan Kendall E. , Thompson-Iritani Sally , Hoenig Donald E. , Ng Zenithson Y. , Hart Lynette A.
Published: January 2023

The veterinary profession has a unique responsibility to animals during the final stages of their lives. The veterinarian’s obligations extend to humane endings, involving all species of animals in a range of circumstances including, but not limited to, euthanasia of individually owned animals, euthanasia of animals for research purposes, depopulation of animals during emergencies, and slaughter of animals raised for food. The veterinary profession continues to improve animal welfare through advances in end-of-life decision-making and humane killing techniques,1–3 but the psychological impacts on veterinarians have not received the same level of consideration. Building on the influential AVMA Humane Endings Guideline, the AVMA recognizes that support for the mental health of veterinarians engaged in such activities needs to be a priority. This article aims to provide the foundation and rationale for improved preparation and establishment of sustainable mental health resources and to offer recommendations on pragmatic solutions to support and prepare veterinary professionals as leaders impacted by participation in humane endings–related activities. While end-of-life decision-making and implementation may present mental health challenges to veterinarians, it is crucial to recognize that there are stressors specific to each situation and that every individual’s experience is valid. Addressing the mental health issues surrounding the decision-making process and implementation of humane endings activities start with a comprehensive understanding of each activity’s unique context and the veterinarian’s leadership role. Therefore, this article highlights the psychological impact of depopulation and its similarities and exclusive challenges compared with euthanasia and humane slaughter.
Recent approaches in the drug research and development of novel antimalarial drugs with new targets
Authors: Chinnappanna Naveen Kumar Reddy , Yennam Gopi , Chaitanya Chaitanya Budagam Haima Naga Venkata , Pottathil Shinu , Borah Pobitra , Venugopala Katharigatta N. , Deb Pran Kishore , Mailavaram Raghu Prasad
Published: January 2023

Malaria is a serious worldwide medical issue that results in substantial annual death and morbidity. The availability of treatment alternatives is limited, and the rise of resistant parasite types has posed a significant challenge to malaria treatment. To prevent a public health disaster, novel antimalarial agents with single-dosage therapies, extensive curative capability, and new mechanisms are urgently needed. There are several approaches to developing antimalarial drugs, ranging from alterations of current drugs to the creation of new compounds with specific targeting abilities. The availability of multiple genomic techniques, as well as recent advancements in parasite biology, provides a varied collection of possible targets for the development of novel treatments. A number of promising pharmacological interference targets have been uncovered in modern times. As a result, our review concentrates on the most current scientific and technical progress in the innovation of new antimalarial medications. The protein kinases, choline transport inhibitors, dihydroorotate dehydrogenase inhibitors, isoprenoid biosynthesis inhibitors, and enzymes involved in the metabolism of lipids and replication of deoxyribonucleic acid, are among the most fascinating antimalarial target proteins presently being investigated. The new cellular targets and drugs which can inhibit malaria and their development techniques are summarised in this study.
Intensive critical care and management of asthmatic and smoker patients in COVID-19 infection
Authors: Lu Dongming , Yaqoob Obaid , Kumar Manish , Kushwah Ajay Singh , Sharma Rahul Kumar , Kumar Devinder , Mavai Yogendra , Khan Rukaiya
Published: January 2023

This century’s most serious catastrophe, COVID-19, has been dubbed “the most life-threatening disaster ever”. Asthmatic persons are even more prone to COVID-19’s complex interplay with the underlying inflammatory condition. In order to protect themselves against COVID-19, asthmatic patients must be very vigilant in their usage of therapeutic techniques and drugs (e.g., bronchodilators, 5-lipoxygenase inhibitors), which may be accessed to deal with mild, moderate, and severe COVID-19 indications. People with asthma may have more severe COVID-19 symptoms, which may lead to a worsening of their condition. Several cytokines were found to be elevated in the bronchial tracts of patients with acute instances of COVID-19, suggesting that this ailment may aggravate asthma episodes by increasing inflammation. The intensity of COVID-19 symptoms is lessened in patients with asthma who have superior levels of T-cells. Several antibiotics, antivirals, antipyretics, and anti-inflammatory drugs have been suggested to suppress COVID-19 symptoms in asthmatic persons. Furthermore, smokers are more likely to have aggravated repercussions in COVID-19 infection. Being hospitalized to critical care due to COVID-19, needing mechanical breathing, and suffering from serious health repercussions, are all possible outcomes for someone who has previously smoked. Smoking damages airways and alveoli, which significantly raises the risk of COVID-19-related health complications. Patients with a previous record of smoking are predisposed to severe COVID-19 disease symptoms that essentially require a combination of bronchodilators, mucolytics, antivirals, and antimuscarinic drugs, to cope with the situation. The present review discusses the care and management of asthmatic and smoker patients in COVID-19 infection.
Tablet characteristics and pharmacokinetics of orally disintegrating tablets containing coenzyme Q10 granules prepared by different methods
Authors: Kashiwagura Yasuharu , Takusagawa Shota , Ikematsu Yasuyuki , Tanaka Shimako , Namiki Noriyuki , Uchida Shinya
Published: January 2023

This study aimed to elucidate the characteristics and pharmacokinetics of orally disintegrating tablets (ODTs) containing coenzyme Q10 (CoQ10) granules prepared by spray drying, hot-melting, and wet granulation. The hardness and disintegration times of CoQ10-ODTs containing 5 % crospovidone were 61.6–81.8 N and < 30 s, respectively; these values indicate that the as-prepared ODTs were adequate for clinical use. The hardness and disintegration times of all ODTs did not change significantly after a 28-day storage period at 30 °C/10 % relative humidity (RH), but storage under high temperature and humidity affected their characteristics. The dissolution and pharmacokinetics of CoQ10-ODTs showed that ODTs prepared using the spray-drying method had the highest dissolution and absorbability among the CoQ10-ODTs tested. These results provide useful information for the preparation of ODTs using CoQ10.
Network Condition-Aware Enhanced Distributed Channel Access for IEEE 802.11e Wireless Ad-Hoc Networks
Authors: Mammar Soulimane , Haffaf Hafid , Rahmouni Kamel
Published: January 2023

The increasing use of multimedia applications in wireless ad-hoc networks makes the support of quality of service (QoS) an overriding necessity. In this article, we present a new extension of the IEEE 802.11e EDCA scheme called NCA-EDCA, which uses the lifetime and the number of retransmissions attempts of a packet to assess the aggressiveness of the environment in order to adjust the channel access parameters to work in the best possible way and improve service quality accordingly. This new extension aims to (1) improve the performance of real-time applications; (2) increase the overall throughput by reducing the collision rate and (3) achieve an acceptable level of fairness. The simulation results show that our extension significantly improves EDCA for better QoS support of multimedia applications. More specifically, it increases throughput of the different flows by no negligible factors and significantly reduces the collision rate while maintaining a high degree of fairness between flows of equal priority.
Perancangan Produk Coffee Table dengan Memanfaatkan Material Bonggol Jagung
Authors: Ramdini Zahra Nuriafadsa , Izzah Nurrul , Masri Andry
Published: January 2023

Penelitian ini merupakan perancangan furnitur berupa coffee table dengan memanfaatkan karakteristik  material bonggol jagung sebagai material utama yang berfungsi sebagai meja untuk mengisi interior rumah bonggol jagung yang diletakkan atau ditempatkan pada bagian teras rumah bonggol jagung untuk aktivitas bersantai. Penelitian ini dilakukan melalui pendekatan identifikasi secara menyeluruh, pembuatan konsep, implementasi konsep, dan diakhiri dengan prototype. Tujuan yang ingin dicapai pada penelitian ini adalah menghasilkan coffee table berbahan bonggol jagung. Pada akhir proses dihasilkan prototype produk coffee table dengan material bonggol jagung dan menawarkan nilai kebaruan berupa penerapan material bonggol jagung pada produk coffee table.
Dietary experiences during fixed orthodontic treatment
Authors: En Priscilla Lee Xie , SoYeon O. , Nor Najwa Nawarah Mohamad , Mei Li , Farella Mauro , Prasad Sabarinath
Published: January 2023

Objectives:

Orthodontists generally recommend avoidance of certain foods during fixed appliance (FA) treatment, based on anecdotal information. This study aimed to identify the dietary preferences and experiences of patients undergoing FA treatment as a step toward the preparation of evidence-based dietary guidelines.

Material and Methods:

Questionnaires regarding dietary preferences and experiences of patients undergoing FA treatment were applied to a convenience sample of 38 adolescents (12 M; 26 F). Open-ended responses were summarized and visualized in a world cloud generator. 5-point Likert and Visual Analog Scales (VAS) were used to record the closed-ended responses. Descriptive statistics and multivariate analysis of variance were used to analyze questionnaire findings.

Results:

Lollies, apples, and nuts frequently caused problems with FA. The most frequent reason for avoiding certain types of food was worry about appliance breakage, followed by pain and sensitivity. VAS scores indicated that toffee and caramel scored highest (65.1% F and 54.1% M) for discomfort followed by corn on the cob (64.4% F and 48.7% M) and apples (56.6% F and 55.3% M). VAS scores did not differ significantly between the sexes (P > 0.05). Nearly, a quarter of the sample reported that FA negatively affected their eating behaviors, causing pain and discomfort during eating. No sex differences (P > 0.05) were found for negative experiences with food.

Conclusion:

Dietary preferences and experiences of patients undergoing FA treatment were identified concerning a New Zealand diet profile. A future study with a larger sample size will help formulate evidence-based dietary guidelines during FA treatment.
GPU-Enhanced DFTB Metadynamics for Efficiently Predicting Free Energies of Biochemical Systems
Authors: Kumar Anshuman , Arantes Pablo , Saha Aakash , Palermo Giulia , Wong Bryan
Published: January 2023

Carrying out metadynamics calculations of large chemical systems with ab initio methods is computationally prohibitive due to the extensive sampling required to simulate the large degrees of freedom in these systems. To address this computational bottleneck, we utilize a GPU-enhanced density functional tight binding (DFTB) approach on a massively-parallelized cloud computing platform to efficiently calculate the thermodynamics and metadynamics of biochemical systems. To first validate our approach, we calculate free energy surfaces of alanine dipeptide and show that our GPU-enhanced DFTB calculations qualitatively agree with computationally-intensive hybrid DFT benchmarks, whereas classical force fields give significant errors. Most importantly, we show that our GPU-accelerated DFTB calculations are significantly faster than previous approaches by up to 2 orders of magnitude. To further extend our GPU-enhanced DFTB approach, we also carried out a 10-ns metadynamics simulation of remdesivir, which is prohibitively out of reach for routine DFT-based metadynamics calculations. We find that the free energy surfaces of remdesivir obtained from DFTB and classical force fields differ significantly, where the latter overestimates the internal energy contribution of high free energy states. Taken together, our benchmark tests, analyses, and extensions to large biochemical systems highlight the use of GPU-enhanced DFTB simulations for efficiently predicting the free energy surfaces/thermodynamics of large biochemical systems.
Moj prijatelj klavir za učitelje: koncepti, veščine in strategije pouka klavirja
Authors: Pucihar Ilonka
Published: January 2023

Osrednji namen monografije je raziskati, preučiti in podati strategije za spodbujanje usvajanja glasbeno-pianističnih konceptov in veščin skozi širše zastavljena področja klavirskega pouka. S tem namenom analitično, sistematično in primerjalno obravnava nekatera temeljna področja klavirske didaktike; od veščin učitelja in odnosne dinamike z učencem, načrtovanja pouka in načinov poučevanja do konceptov in veščin učenja klavirja ter razvojnih značilnosti otrok v povezavi z glasbenim razvojem. Zajema slušne veščine, ritmične koncepte in veščine, koncepte in veščine branja, tehnične, ustvarjalne in muzikalne veščine ter podaja strategije učenja in poučevanja skozi prizmo sodobnih pristopov, ki se osredotočajo na učenca in ki mu omogočajo vsestranski, celovit glasbeno-pianistični razvoj. Ugotavljamo, da se v našem izobraževalnem sistemu večinoma poučuje skozi »tradicionalni« pristop poučevanja klavirja, ki je osredotočen na učenje novih skladb, tehnično-muzikalno izdelovanje in interpretacijo zapisanih glasbenih del. Nekatera področja klavirskega pouka nimajo tako pomembnega mesta. To je potrdila tudi raziskava stališč 95 učiteljev klavirja slovenskih javnih glasbenih šol o vključevanju improvizacije v pouk klavirja. Učitelji imajo do vključevanja improvizacije v pouk klavirja pozitivna stališča in imajo z njim pozitivne izkušnje. Menijo, da ima improvizacija pomembno vlogo za številne dejavnike glasbenega udejstvovanja in glasbenega razvoja učencev, kljub temu pa ji posvečajo malo pozornosti. Malo pozornosti posvečajo tudi področjem, kot so kompozicija, branje a prima vista, transpozicija, igranje po posluhu, gibanje celega telesa. Teoretični temelji, podkrepljeni s strategijami tako učenja kot poučevanja, praktičnimi vajami in z notnimi primeri, nudijo temeljno študijsko literaturo bodočim učiteljem klavirja in podlago za njihovo nadaljnje raziskovalno pedagoško delo.
Uso de excel para mezcla de concretos
Authors: Ortiz Zambrano Juan Alejandro
Published: January 2023

El hormigón es uno de los materiales compuestos más utilizados en la construcción. Este material ofrece grandes ventajas frente a otros materiales, lo que demuestra por qué ha sido tan utilizado y perfeccionado a lo largo de la historia de la ingeniería, su rentabilidad se basa en el hecho de que este material tiene una gran resistencia a eventos naturales como los cambios de temperatura, además de tener una impermeabilidad media al agua, lo que amplía más su área de uso, además de ser muy trabajable con propiedades que permiten colocarlo, compactarlo y proporcionar un buen acabado con facilidad. Por último, por todas estas características, este material bien hecho es muy duradero y los trabajos basados en él se mantienen y soportan el paso del tiempo y daños que otros materiales no resistirían. La resistencia de diseño o resistencia promedio está a cargo del ingeniero calculador ya que es este quien verá todos los aspectos de la obra, sus propiedades específicas como la carga viva y muerta, la flexión permisible, el tipo de trabajo, entre otros. A partir de esto poder determinar qué resistencia y por tanto qué características debe poseer el hormigón para que la obra cumpla al menos con la durabilidad establecida para la obra. Este estudio presenta el desarrollo de una metodología para el diseño de mezclas de hormigón utilizando Excel. Para su ejecución, se trabajó con información del American Concrete Institute y con las disposiciones del NSR-2010, donde se sintetizó esta información proporcionada y mediante el uso de gráficos y métodos matemáticos las tablas se transformaron en ecuaciones que interpolan y extrapolan la información de acuerdo con la norma. Esta herramienta permite al usuario introducir los datos que tiene de la obra y trabajar sobre lo que ha promediado datos o tabla de datos con diferentes unidades y a través de sus datos disponibles llega a la relación de los materiales para la fabricación de hormigón y mortero en kilogramos y su posterior disposición en cantidad de agua si es necesario y con los datos obtenidos en el laboratorio, esto le da mayor versatilidad al usuario, le ahorra tiempo al usuario y le da mayor confianza sobre su diseño de mezcla ya que el sistema funciona con una relación del 100% sobre los datos del estándar y toma los decimales que el programa permite dando al final la respuesta con una simple cifra decimal a cumplir.
La historia del pavimento enfermo del parque del Cholado: estudio de caso
Authors: Tobar Vallejo Evelyn Tatiana
Published: January 2023

Jamundí, municipio ubicado al sur del departamento del Valle del Cauca, suele ser paso obligado de personas y mercancía cuyo destino es el interior de Colombia, razón por la cual la calidad de infraestructura vial del municipio redunda en el confort de los usuarios. El presente documento tiene como objetivo evidenciar las fallas de los pavimentos en un sector de alto atractivo turístico en la región: El parque del Cholado. Para adelantar la investigación se consultó información sobre la relación causa y efecto mostrado dentro de cada tipología de falla, se realizó un trabajo de campo posibilitando de esta manera el reconocimiento de la falla pudiendo de esta forma profundizar en los factores y las circunstancias que conllevaron a la disminución de la vía útil del pavimento en el sector. La dinámica de trabajo empleada en este estudio es relevante para la formación de los futuros ingenieros civiles ya que permite ver de manera práctica la aplicación de los distintos conceptos teóricos presentados en las asignaturas del pensum de la carrera. Las quejas de la comunidad sobre el estado de las vías y la verificación de los proyectos realizados en los últimos cuatro años mostraron que las mayores afectaciones surgen por la falta de mantenimiento oportuno y las reparaciones mal ejecutadas que desencadenan en problemática de mayor magnitud. Los resultados del estudio aportan un referente teórico-práctico de los tipos de fallas en los pavimentos y las posibles medidas correctivas para cada caso, así como también la identificación de los puntos críticos para intervención inmediata. Como era de esperarse, el estudio mostró que los sectores más afectados por esta problemática son las vías alrededor de “El parque del cholado” que son vías de alta concurrencia y demanda de tránsito.
Recuperación de compuestos fenólicos de la pulpa del café por medio de una percolación a través de un extractor Soxhlet en escala piloto
Authors: Vidal Eduardo , Sierra Ramírez Rocío , Cruz Reina Luis Jorge
Published: January 2023

Entre los múltiples residuos generados por la producción cafetera destaca la pulpa o cereza del fruto, la cual es responsable por cerca del 30% del peso en base seca del total del grano. La pulpa del café ofrece diferentes compuestos químicos de alto interés para la industria alimenticia y farmacéutica, donde destacan los compuestos fenólicos disponibles en esta, en especial los Ácidos Clorogénico, Cafeico, Ferúlico y Cumárico. Se realizó una extracción de los compuestos fenólicos por medio de una percolación en un equipo Soxhlet para evaluar el impacto del tipo de solvente, el tiempo de extracción y la relación de pulpa:solvente en el contenido de fenoles totales (TPC) del extracto. Se caracterizó el TPC de los 30 extractos realizados usando el método de Folin-Ciocalteu usando Ácido Gálico para la curva de calibración. Se encontró una influencia significativa en el TPC de cada extracto por el tipo de solvente utilizado en la extracción, mientras que los otros dos factores no fueron estadísticamente significativos. Se obtuvo un rendimiento máximo de de contenido de polifenoles por gramo de pulpa usado en la extracción utilizando Etanol al 95% de pureza. Se discute una oportunidad industrial en la extracción de los mencionados compuestos de la pulpa de café, donde los rendimientos alcanzados ofrecen un valor agregado al residuo, pudiendo beneficiar a la agroindustria cafetera con ingresos adicionales para los caficultores.
Evaluación de algunas propiedades físico-mecánicas en muestras cilíndricas de concreto estructural con sustitución de 5%, 10% y 15% de cemento por escoria de siderurgia
Authors: Buitrago Muñoz Yudy Alejandra
Published: January 2023

En el presente trabajo se evaluaron algunas propiedades físico-mecánicas en muestras cilíndricas de concreto con sustitución de 5%, 10% y 15% de cemento por escoria de siderurgia. Primero, se obtuvieron algunos residuos subproducto de algunas industrias de la región de Boyacá con el fin de caracterizarlos y elegir el más adecuado para sustituir el cemento en mezclas de concreto. Los residuos que se caracterizaron fueron, ceniza de termoeléctrica, escorias de siderurgia, cascara de huevo natural, cascara de huevo calcinada y cenizas provenientes de la fabricación del ladrillo. Luego, los residuos elegidos se caracterizaron física y químicamente. La caracterización física se realizó mediante el ensayo de densidad; mientras que, la caracterización química se realizó mediante actividad puzolánica. Según los resultados obtenidos el residuo más adecuado para sustituir al cemento fue la escoria de siderurgia. Los valores obtenidos para este residuo fueron de, 2.62 g/cm3 para la densidad y 1877.600 mg para la actividad puzolánica. Pese a que los valores obtenidos difieren con los del cemento, la escoria presentó la mayor actividad puzolánica mostrando la posibilidad de reaccionar con el cemento. Después de elegir el residuo a implementar se agregó a la mezcla de concreto. Se realizaron 36 cilindros de concreto y a estos se le midió la resistencia a la compresión a los 7, 14 y 28 días. Los resultados mostraron que para 7 días con 5% obtuvo una resistencia de 29MPa, para 14 días con 5% obtuvo una resistencia de 31.3 MPa, para 28 días con 5% obtuvo una resistencia de 33.5; en cambio para las muestras patrón se obtuvieron los siguientes resultados: para 7 días obtuvo una resistencia de 30 MPa, para 14 días obtuvo una resistencia de 33.5 MPa, para 28 días obtuvo una resistencia de 38.6 MPa. Los resultados obtenidos mostraron que a medida que se aumenta el porcentaje de escoria la resistencia a la compresión disminuye a edades mayores. Por otro lado, se recomienda trabajar la escoria de siderurgia en un tamaño menor de 45 micras para que las propiedades del concreto no se vean tan afectadas, ya que en la revisión del estado del arte si aumentaba la resistencia ya que el tamaño de su partícula era del mismo tamaño de la del cemento, al hacer el ensayo se comprobó que la partícula más grande disminuye la resistencia.