bluuebunny/crossref_metadata_2025 huggingface dataset:
Therapeutic Gene Silencing of CKAP5 leads to lethality in genetically unstable cancer cells.
Authors: Chatterjee Sushmita , Naidu Gonna Somu , Hazan-Halevy Inbal , Grobe Hanna , Ezra Assaf , Ramishetti Srinivas , Sprinzak David , Zaidel-Bar Ronen , Peer Dan
Published: July 2022

Cell mitosis is an attractive target for cancer therapy. Presently, anti-mitotic drugs are limited to tubulin binding agents and kinase inhibitors. While there is a long list of potential microtubule associated protein targets that play an important role in tubulin function, their therapeutic potential remains largely unexplored due to the lack of target specific agents. Herein, we explored the therapeutic potential of targeting Cytoskeleton Associated Protein 5 (CKAP5), an important microtubule-associated protein, with CKAP5 targeting siRNAs that are entrapped in lipid nanoparticles (LNPs). We have screened the effect of CKAP5 silencing in a panel of solid cancer cell lines and demonstrated that silencing CKAP5 specifically affects genetically unstable cell lines, among which a chemo-resistant ovarian cancer cell line is most susceptible. CKAP5 knockdown led to loss of EB3 comet dynamics followed by apoptosis. Finally, we demonstrated the therapeutic potential in an in-vivo ovarian cancer model, showing increased survival rate in CKAP5 silenced LNP treated group by 80 % (p<0.0001). Taken together, our results may ultimately be translated into novel therapeutic modality for Ovarian Cancer and be utilized for other types of cancers.
Mapping the Restoration of Degraded Peatland as a Field of Research Area: A Scientometric Review
Authors: Apori Samuel Obeng , Macmillan Douglas , Giltrap Michelle , Tian Furong
Published: July 2022

Degraded peatland reduced many ecosystem services such as water quality and quantity, biodiversity, carbon storage, climate regulations and other cultural benefits. Therefore, several initiatives for the restoration of degraded peatland (RDP) have been attempted to restore the ecosystem processes, productivity and services of the degraded peatland to its original natural condition. Notwithstanding the popularity of RDP research among researchers and industry practitioners, a quantitative technique to map a comprehensive survey of the intellectual core and the general body landscape of knowledge on RDP research does not exist. In this study, a scientometric analysis was employed to analyze 522 documents using VOSviewer and CiteSpace. The Web of Science database was used to retrieve bibliographic records using the advanced search “TS (topic) =(‘drained peatland restoration’ OR ‘drained bog restoration’ OR ‘drained mire restoration’ OR degraded peatland restoration’ OR ‘degraded bog restoration’ OR ‘drained peatland reclamation’ OR ‘drained bog restoration’ OR ‘degraded peatland reclamation’ OR ‘degraded bog reclamation’ OR ‘drained mire restoration’ OR ‘degraded mire reclamation’ OR ‘degraded fen restoration’ OR ‘drained fen reclamation’). The outcome sought to provide relevant information in RDP research such as (i) publication trends (ii) research outlets (iii) most influential keywords (iv) most influential institutions and authors (v) top influential countries active in RDP research. In addition, four clusters were identified for ascertaining the central theme of RDP research in which cluster one is linked to the central research theme-“impact of drainage on peatland ecosystem services; cluster two focused on the impact of peatland restoration on greenhouse gas emissions; cluster three is associated with peatland restoration and biogeochemical properties and cluster four is related to peatland restoration and species richness. A new research hotspot such as soil respiration was identified via the keywords with the strongest citation bursts. This study will provide the various stakeholders such as industry, journal editors, policymakers and researchers instinctive understanding of the research status and the development frontier of RDP research
An enhancement of instruments for solution of general transmission line equations with method of lines, impedance-/admittance and field transformation in combination with finite differences.
Authors: Spiller Waldemar
Published: July 2022

The Method of Lines (MoL) in combination with impedance/admittance and field transformation (IAFT) is used to analyze electromagnetic waves. The used cases are waveguiding structures in microwave technology and optics. The core of the theory is the solution of generalized transmission line equations (GTL). In the case of complex structures, a combination with finite differences (FD) can be used. The quality of this solution essentially depends on the effectiveness of the used interpolation of the differences. The individual steps of the FD are permanently linked to the steps of the fully vectorial impedance/admittance and field transformation, so standard libraries cannot be used. Two approaches based on the linear and quadratic interpolation were built into the impedance/admittance and field transformation in the past.

However, the degree of improvement due to one or another kind of interpolation depends on the concrete behavior of the solution sought.

In the case of complex structures, choosing the appropriate type of interpolation should be an effective aid. In this paper, an extension of the family of built-in methods is proposed - with the possibility of being able to build any known numerical method from the class of one-step or multi-step methods into the GTL solution. These can be higher-order methods, including fast explicit methods, or particularly stable implicit methods. The transmission matrices for the impedance/admittance and field transformation serve as the building site. To illustrate the procedure, some different methods are integrated into the GTL solution. The efficiency of the solutions is tested on some test structures and compared with each other and with existing solutions. The relevant waveguide specifics were discussed. Initial systematics and recommendations for users were derived.
ANALYSIS OF CORRELATION OF STROMAL CD10 EXPRESSION INCARCINOMABREASTNOSTYPEWITH HER2/NEU
Authors:   Assistant Professor, DepartmentofPathology,Government Mohankumaramangalam Medical College,Salem,/TamilNaduDr.MGRMedicalUniversity,Chennai,India., Ulaganathan S. , Arshad A. Abu ,   Assistant Professor, DepartmentofPathology,Government Mohankumaramangalam Medical College,Salem,/TamilNaduDr.MGRMedicalUniversity,Chennai,India., Duraisamy R. ,   Assistant Professor, DepartmentofPathology,Government Mohankumaramangalam Medical College,Salem,/TamilNaduDr.MGRMedicalUniversity,Chennai,India.
Published: July 2022

Background:Breastcancerisoneofthemostcommoncanceramongwomen.Stromaplaysanimportantpathogeneticroleincarcinomaofbreast.Stromalmarkercouldbeusedforassessingtheprognosisofbreastcancer. Methods:30invasiveductalcarcinomaofbreastNOStypewereselected.Hematoxylinandeosinstainingwasdone.ImmunohistochemistrywasdonewithCD10,andHER2.CD10expressioninstromawasstudiedandstatisticallyanalyzedwithHER2. Results:strongpositivityforstromalCD10wasobservedin46%(14outof30)ofcases.10outof14(71%)CD10positivecasesshowedHER2/neu positivity.CD10expressionwassignificantlyassociatedHER2/neupositivity. Conclusions:StromalCD10expressionisdirectly correlatedwithHER2receptorpositivity.CD10couldbeusedasnew prognosticmarkerincarcinomaofbreast.
Matematiksel Modelleme Yeterlikleri Ölçeği’nin Geliştirilmesi ve Psikometrik Özelliklerinin Belirlenmesi: Özel Yetenekliler Örneklemi
Authors: ÖZBEK Gülnur , KÖSE Erdoğan
Published: July 2022

Giriş: Geliştirilen modeller ile özgün projeler oluşturma açısından kilit bir kavram olan matematiksel modelleme bu yönüyle özel yetenekli gençlerin eğitiminde kullanılmaktadır. Modelleme yeterliklerinin belirlenmesi, gelişimine ihtiyaç duydukları aşamaların tespit edilmesi nasıl eğitim uygulamaları ve program farklılaştırmaları yapılacağına karar verilmesi açısından önemli veriler sağlayacaktır. Araştırmada matematiksel modelleme yeterlikleri ölçeğini geliştirmek ve psikometrik özelliklerini belirlemek amaçlanmaktadır.Yöntem: Araştırma betimsel bir çalışmadır. Araştırma iki farklı örneklem grubu katılımı ile gerçekleştirilmiştir. İlk grupta 301 katılımcıdan elde edilen verilerle açımlayıcı faktör analizi (AFA) yapılmıştır. İkinci grupta 185 katılımcıdan elde edilen veriler ile doğrulayıcı faktör analizi (DFA) yapılmıştır.Bulgular: Geliştirilen ölçek ‘Tamamen katılıyorum’, ‘Katılıyorum’, ‘Orta derecede katılıyorum’, ‘Katılmıyorum’ ve ‘Hiç katılmıyorum’ şeklinde derecelendirilmiş olup ters kodlanılması gerekli olan maddeler bulunmamaktadır. Ölçeğin alt faktörlerinin ‘Gerçek yaşam problemini belirlenme’, ‘Problemi anlama ve sadeleştirme’, ‘Matematikselleştirme’, ‘Matematiksel olarak çalışma’ ve ‘Yorumlama ve doğrulama’ olduğu belirlenmiştir. Güvenirliği belirlemek amacıyla hesaplanan Cronbach alfa iç tutarlılık katsayıları ölçeğin bütünü için 0.958 olarak ve sırasıyla alt faktörler için .811, .900, .883, .820 ve .927 olarak hesaplanmıştır. Ölçeğin uyum indeksleri (χ2 / df = 2.00, GFI = .90, RMSEA = .075, SRMR = .063, IFI = .97, NNFI = .97, CFI = .97, NFI = .94, PNFI = .86) belirlenmiştir.Tartışma: Araştırmanın sonucunda, geliştirilen 5 faktörlü 31 maddelik ölçeğin sonraki çalışmalarda kullanılabilecek yeterli psikometrik özelliklere sahip olduğuna ulaşılmıştır. Geliştirilen ölçek modelleme sürecinde hem bütüncül olarak hem de aşamalarında kısmi olarak ölçüm yapmayı sağlamaktadır. Bu bağlamda bu araştırma kapsamında geliştirilen ölçek ile gerçekleştirmede en iyi olunan aşamalar ile en zorlanılan ve gelişimine ihtiyaç duyulan aşamaların belirlenmesi sağlanabilir.
Dulaglutide Alleviates Alzheimer's Disease by Regulating Microglial Polarization and Neurogenic Activity
Authors: Wang Yun , Han Bojun
Published: July 2022

Backgrounds:

Increasing research has proved that microglial activation, polarization,
and inflammatory response in the brain affect the pathology of Alzheimer's disease. Hence, employing
reagents targeted to microglial functions to optimize the brain microenvironment may become
a promising therapeutic method for Alzheimer's disease.

Methods:

The phagocytosis and clearance of Aβ1-42 were detected using western blot and immunofluorescence
assay. The cell viability was determined via 3-(4, 5-Dimethylthiazol-2-yl)-2, 5-
diphenyltetrazolium bromide (MTT) or cell counting kit-8 (CCK-8) assay. The load of proinflammation,
in addition to anti-inflammation factors, was measured through an enzyme-linked
immunosorbent (ELISA) assay. Flow cytometry was employed to estimate the apoptotic cells. The
protein level related to microglial polarization and neuronal injury was detected via western blot.
The length of the neuronal synapse was investigated using an immunofluorescence assay.

Results:

Dulaglutide significantly promoted microglia to phagocytose and removed the Aβ plague.
Additionally, dulaglutide treatment inhibited the production of pro-inflammatory factors, including
tumor necrosis factor (TNF)-α, interleukin -1β, and IL-6, whereas it increased the load of antiinflammatory
molecules, such as IL-10 affected by Aβ1-42 exposure. Further investigation verified
that Aβ1-42 down-regulated YM1/2 positive M2 microglial polarization phenotype but
up-regulated cyclooxygenase-2 (Cox2) positive M1 microglia. However, treating with dulaglutide
effectively counteracted these effects. Moreover, dulaglutide dramatically recovered primary cortical
neuron cell viability and inhibited cell apoptosis influenced by Aβ1-42. Furthermore, the dulaglutide
also reversed neuronal synapse injury after exposure to Aβ1-42.

Conclusion:

Altogether, this investigation verified that dulaglutide improved Aβ-induced inflammation
and neuronal injury by mediating the activation and polarization of microglia, thereby alleviating
Alzheimer's disease efficiently.
Naturally Occurring Compounds as Potential Inhibitors of Epidermal Growth Factor Receptors (EGFRs)
Authors: Oktavia Listiana , Fuad Asrul Muhamad , Senjaya Seni Kurnia , Yuliyawati Yuliawati
Published: July 2022

The Epidermal Growth Factor Receptor (EGFR) activation appears essential in tumor growth and progression. Targeting EGFR signaling pathway becomes an exciting area in cancer therapy. Synthetic chemotherapy drugs have been used to treat some EGFR signaling in various cancer cells. The utilization of naturally occurring compounds as EGFR inhibitors is exciting to be explored due to the urgent need to combat resistance over current EGFR inhibitors. In this review, we first summarize the schematic role of EGFR in cancer and the current EGFR inhibitor used, its advantage, and disadvantage. Next, we discuss the natural products that have been reported as the source of EGFR inhibitors. The discussion covers the natural products which are majorly reported from the year 2005-2020. A total of 21 groups of natural compounds and their derivatives were reported to have the potential to inhibit EGFR signaling pathways. We then discuss the advanced technologies and approaches that rapidly discover EGFR inhibitor-based natural products. Hopefully, this literature review could increase the excitement of finding an effective EGFR pathway inhibitor from natural products.
An Incidental Discovery of Supracardiac Left-sided Partial Anomalous
Pulmonary Connection and Dilation of the Azygos Vein Detected in
Adulthood
Authors: Lizarazo Ortega David A. , Rivero Oscar
Published: July 2022

Introduction:

Anomalous pulmonary venous connection is a rare congenital variant of the
pulmonary veins drained into the right atrium. The left-side partial anomalous pulmonary connections
are usually detected in adulthood and occasionally drain into the left brachiocephalic vein.

Case Description:

An asymptomatic 63-year-old woman with a known history of left carotid body
paraganglioma was admitted to our institution to evaluate this tumor by computed tomography angiography
of the neck and brain. As an incidental finding, CTA demonstrated a supracardiac partial
anomalous pulmonary venous connection between the left upper pulmonary vein and the left innominate
via the vertical vein. Additionally, dilation of the azygos vein was observed.

Conclusion:

Supracardiac left-sided partial anomalous pulmonary venous connection is a rare vascular
variant, usually asymptomatic and found incidentally in adults.
The Impact of Excessive Use of Digital Devices During the Pandemic of Corona Virus Disease (COVID-19) Among Saudi Arabia Population
Authors: Almuhwwis Abdulrahman A. , Alshumaym Abdulelah A. , Moafa Majid A. , Alluwimi Mohammed , Alghamdi Mansour A. , Alrasheed Saif Hassan
Published: July 2022

Background:

A substantial increase in using digital devices was observed among the population due to staying at home as a result of the quarantine during the coronavirus pandemic. Consequently, ocular symptoms appeared due to spending several hours of screen time per day.

Objective:

The current study aimed to assess the impact of excessive use of digital devices during the pandemic of coronavirus among the Saudi population.

Methods:

A community-based cross-sectional study was carried out from November 2020 to January 2021 among the Saudi population. Data were collected by using Ocular Surface Disease Index (OSDI) questionnaires for the assessment of symptoms related to dry eye and their effect on vision. A logistic regression model was used to evaluate the association between the risk factors and the symptoms of dry eye. SPSS 22nd edition was used, any p-value <0.05 was considered significant.

Results:

Out of 1573 participants, 93.8% used mobile, 42.4% experienced uncomfortable sensitivity to the light. There were 49.15% of the participants who showed that none of the time they felt blurry vision, 54.8% did not report double vision, and 30.5% who felt a headache recently after quarantine. About 48% of the participants did not have any ocular symptoms, while 52% had dry eye symptoms (mild 22.3%, moderate 13.7%, and severe 15.9%). When the logistic regression model of risk factors associated with severe symptoms of dry eye was applied, wearing a contact lens was the most significant variable (p<0.0001).

Conclusion:

Dry eye symptoms increased during the quarantine, which indicated that the digital device users need to learn more about the preventive measures from practitioners in eye healthcare. More studies are warranted to assess the impact of digital device usage on all age groups starting from children up to the elderly population.
Emprendimiento social, innovación y derechos humanos: Una perspectiva desde la Acción Integral
Authors: Fonseca-Ortiz Tania Lucia , Castro-Aldana Edwin Alberto , Díaz-Burgos Jesús Ferney
Published: July 2022

Esta obra explora los fundamentos teóricos del emprendimiento en el contexto de las relaciones cívico-militares, específicamente entre las comunidades, la universidad, el Ejército Nacional de Colombia y la empresa. Así, a partir de un detallado análisis sobre la multiplicidad de necesidades que ha generado el desarrollo empresarial, económico y social en el país luego del acuerdo de paz, propone estrategias de innovación e investigación en las que convergen las distintas Fuerzas de la institución castrense y los actores externos del sector privado. Desde esta perspectiva, cada uno de los capítulos expone nuevos procesos productivos que no solo se adecúan a estas necesidades globalizadas, sino que también tienen en cuenta los fundamentos históricos y las prácticas de la Acción Integral en su función social coordinada y resolutiva. En este sentido, el libro constituye un valioso aporte para analizar y reflexionar las acciones coordinadas que buscan fortalecer el vínculo entre civiles y militares al amparo de los Derechos Humanos, la atención de las problemáticas sociales y la generación coherente de soluciones para contribuir a consolidar la paz multidimensional en Colombia.
Development of an Interoperable and Easily Transferable Clinical Decision Support System Deployment Platform: System Design and Development Study
Authors: Yoo Junsang , Lee Jeonghoon , Min Ji Young , Choi Sae Won , Kwon Joon-myoung , Cho Insook , Lim Chiyeon , Choi Mi Young , Cha Won Chul
Published: July 2022

Background

A clinical decision support system (CDSS) is recognized as a technology that enhances clinical efficacy and safety. However, its full potential has not been realized, mainly due to clinical data standards and noninteroperable platforms.

Objective

In this paper, we introduce the common data model–based intelligent algorithm network environment (CANE) platform that supports the implementation and deployment of a CDSS.

Methods

CDSS reasoning engines, usually represented as R or Python objects, are deployed into the CANE platform and converted into C# objects. When a clinician requests CANE-based decision support in the electronic health record (EHR) system, patients’ information is transformed into Health Level 7 Fast Healthcare Interoperability Resources (FHIR) format and transmitted to the CANE server inside the hospital firewall. Upon receiving the necessary data, the CANE system’s modules perform the following tasks: (1) the preprocessing module converts the FHIRs into the input data required by the specific reasoning engine, (2) the reasoning engine module operates the target algorithms, (3) the integration module communicates with the other institutions’ CANE systems to request and transmit a summary report to aid in decision support, and (4) creates a user interface by integrating the summary report and the results calculated by the reasoning engine.

Results

We developed a CANE system such that any algorithm implemented in the system can be directly called through the RESTful application programming interface when it is integrated with an EHR system. Eight algorithms were developed and deployed in the CANE system. Using a knowledge-based algorithm, physicians can screen patients who are prone to sepsis and obtain treatment guides for patients with sepsis with the CANE system. Further, using a nonknowledge-based algorithm, the CANE system supports emergency physicians’ clinical decisions about optimum resource allocation by predicting a patient’s acuity and prognosis during triage.

Conclusions

We successfully developed a common data model–based platform that adheres to medical informatics standards and could aid artificial intelligence model deployment using R or Python.
mHealth Apps for Low Back Pain Self-management: Scoping Review
Authors: Rintala Aki , Rantalainen Roy , Kaksonen Anu , Luomajoki Hannu , Kauranen Kari
Published: July 2022

Background

The role of self-management in health promotion, as well as prevention and rehabilitation, is increasing through the use of mobile health (mHealth) apps. Such mHealth apps are also increasingly being used for self-management of low back pain (LBP), but their effectiveness has not been sufficiently explored.

Objective

The aim of this scoping review was to provide an overview of the literature on self-management mHealth apps and their effects on the levels of pain and disability in people with LBP.

Methods

We applied the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) methodology, including a priori research questions. A literature search was conducted in 2 databases (PubMed and PEDro) for studies published between January 1, 2015, and June 17, 2021. Interventional, cohort, or case series studies with an interventional period were included if the mHealth app included built-in self-management content, the app was used for self-management for people with LBP, and the study reported outcomes regarding pain and disability in people with LBP.

Results

In total, 7 studies were selected for the review with overall 2307 persons with LBP, of whom 1328 (57.56%) were women. Among the studies (5/7, 71%) that reported the type of pain, 85% (390/459) of the participants were experiencing chronic LBP. A total of 5 different mHealth apps were identified, of which 4 contributed to a statistically significant reduction in LBP and clinically meaningful changes. Of the 7 studies, 4 (57%) used 4 different assessments for disability, of which 3 (75%) showed statistically significant improvements in the level of functional ability of participants in the experimental groups using an mHealth app with built-in self-management content for LBP.

Conclusions

This scoping review supports the conclusion that people with LBP may benefit from mHealth apps that provide self-management content. However, the generalizability of the findings is limited because of heterogeneity in the pain characterization of the included participants and the intervention durations. More high-quality studies with longer follow-up periods to investigate personalized mHealth approaches are recommended for LBP self-management.
Communication Deficits due to Alzheimer’s Disease: A Multimodal Vision-and-Language Analysis (Preprint)
Authors: Liu Ziming , Collier Parker , Paek Eun Jin , Yoon Si On , Casenhiser Devin , Zhou Wenjun , Simpson Skylar , Zhao Xiaopeng
Published: July 2022

BACKGROUND

Referential communication refers to one’s capacity to successfully describe a target object or an idea to a conversational partner. Previous research has demonstrated that referential communication tasks (RCTs) combined with natural language processing techniques can achieve superior performance of detecting communication deficits in people with Alzheimer’s Disease (AD). Therefore, a deep understanding of attributes for the enhanced performance on AD classification is crucial.

OBJECTIVE

In this study, we aim to apply machine learning to quantify the relevance of each descriptive expression produced by participants to the corresponding images and test if this relevance score is different between people with AD and cognitively healthy older adults.

METHODS

We used the CLIP model to calculate the semantic association between the participants’ transcripts and the corresponding images being described. Statistical analyses were then conducted to examine the differences between people with AD and cognitively healthy older adults as well as their communication performances in different experimental conditions.

RESULTS

The analysis results are significantly different between the two groups. Moreover, the results vary significantly across different experimental conditions in the cognitively healthy group, but not in the AD group.

CONCLUSIONS

This paper is the first study on multimodal vision-language analysis of RCTs using CLIP. The study reveals the feasibility of applying multimodal vision-and-language analysis to differentiate the semantic representation performance between cognitively healthy older adults and people with AD. The difference may be related to communication deficits in vision-language association. Further research is needed to evaluate the potential of using CLIP for automatic dementia screening using interactive image-based description tasks.
Changes in food insecurity during the COVID-19 pandemic among individuals using a telehealth and nutrition platform (Preprint)
Authors: Bakre Shivani , Shea Benjamin , Ortega Kaylee , Scharen Jared , Langheier Jason , Hu Emily A.
Published: July 2022

BACKGROUND

Food Insecurity is a complex public health problem affecting many individuals in the United States. Digital health interventions that promote behavior change and provide access to affordable and healthy food may help to alleviate food insecurity.

OBJECTIVE

The aim of this study was to characterize users of Foodsmart, a telehealth and nutrition platform, with food insecurity and to evaluate changes in diet and food insecurity.

METHODS

We retrospectively analyzed data collected from 4,595 adults who used Foodsmart between February-October 2021. Participants self-reported their diet, demographics, biometrics, and food insecurity status. We examined baseline characteristics of participants by food insecurity status, associations between characteristics and baseline food insecurity, and changes in diet quality and food insecurity status.

RESULTS

We found that 16% of participants were food insecure at baseline. Among participants who were food insecure at baseline, 61% improved their nutrition and 29% responded that they were food secure at follow-up, with an increasing percentage achieving food security with longer enrollment time.

CONCLUSIONS

Telehealth and nutrition platforms may help users improve household food security.
Fuzzy Sβ-continuous and fuzzy Sβ-open mappings
Authors: Dhar Runu
Published: July 2022

The aim of this paper is to introduce the notion of fuzzy mappings, known as fuzzy Sβ-continuous mappings. Some of their basic properties and characterization theorems have been investigated in fuzzy topological spaces. The notion of fuzzy Sβ-open mappings have been introduced and some of their characterization theorems and basic properties have also been studied in fuzzy topological spaces.
Síndrome post COVID-19 en una estudiante de pregrado de medicina. Caso clínico
Authors: Dzul-Toledo Rubí Angélica , Contreras-González Noé
Published: July 2022

Introducción. La enfermedad COVID-19 es causado por el virus SARS-CoV-2 que se constituyó en una pandemia a nivel mundial. El personal médico y los estudiantes de pregrado y posgrado de la carrera de medicina tienen un riesgo significativamente mayor para contraer dicha enfermedad, sobre todo si no se cuenta con el material y protocolo de atención, para esta enfermedad emergente. Aunque la mayoría de los pacientes con esta enfermedad mejoran en semanas, algunos presentan síntomas posteriores que en conjunto se llama Síndrome Post COVID-19 (SP-COVID-19). El mecanismo fisiopatológico que se genera es un proceso inflamatorio severo y persistente. Factores como enfermedades pulmonares, cardiovasculares, obesidad y diabetes mellitus, aumentan considerablemente el riesgo de dicha complicación. Las principales manifestaciones del SP-COVID-19 son: fatiga, disnea, trastornos del dormir, dificultad para concentrarse, hipertermia, cefalalgia, mialgias, tos, depresión, disnea y anosmia/ageusia. Estos enfermos requieren evaluación médica integral, seguimiento y rehabilitación neuropsicológica. Caso clínico. Estudiante de medicina femenino de 31 años, quien se encontraba realizando prácticas profesionales (internado médico de pregrado) en diciembre de 2020 en un hospital general del estado de Guanajuato, donde se contagió de SARS-CoV-2 y enfermó de COVID-19, confirmado por PCR y tomografía de tórax. Fue tratada con intubación, corticosteroides y anticoagulantes. Tras la fase aguda de la enfermedad, presentó SP-COVID-19 y fue rehabilitada con oxigenoterapia, neuropsicología y actividad física por más de un año. Conclusiones. La pandemia COVID-19 causada por el SARS-CoV-2 ha tenido un gran impacto mundial con un alto riesgo para los profesionales de la salud y sobre todo para los estudiantes de pregrado que efectúan prácticas profesionales en los centros hospitalarios con limitaciones de recursos e infraestructura para enfermedades emergentes. El SP-COVID-19 afecta aproximadamente a la tercera parte del personal de atención a la salud que padeció la enfermedad, lo cual repercute en la calidad de vida, desempeño laboral y social. Palabras clave: Síndrome Post COVID-19, estudiante de pregrado de medicina, complicaciones.
Relación entre la ansiedad, depresión e insomnio con la calidad de vida en mujeres adultas en proceso de envejecimiento reproductivo. Una revisión sistemática
Authors: Resendiz-Oviedo Maria Guadalupe , Sánchez-Rodríguez Martha A.
Published: July 2022

Antecedentes. La menopausia es el periodo que marca el final de la función ovárica, se determina cuando se observa el cese de la menstruación por un año. En promedio ocurre entre los 45 y 55 años. Las mujeres en la clínica reportan elevada frecuencia de síntomas psicológicos y una disminución de la calidad de vida durante esta etapa, pero la información al respecto es variada e inconsistente. Objetivo. Presentar una síntesis del conocimiento sobre la relación entre la ansiedad, depresión o insomnio con la calidad de vida en mujeres adultas en proceso de envejecimiento reproductivo Método. Se realizó una búsqueda sistemática en seis bases de datos: PubMed, Scopus, Web of Science, LILACS, SciELO y TesiUNAM. Se incluyeron estudios observacionales siguiendo una estructura PEO en la pregunta de investigación, la revisión se efectuó hasta el 09 de diciembre de 2021. Se usó la herramienta Newcastle-Ottawa para la evaluación del riesgo de sesgo. Resultados. Se obtuvieron 818 títulos en las bases de datos y 85 títulos de registros en TesiUNAM, quitando duplicados y excluyendo la información que no cumplía con los criterios de inclusión, quedaron tres artículos para el análisis cualitativo. Se encontró que la calidad de vida se ve alterada por los trastornos psicológicos, aunque los estudios no son fácilmente comparables por la variedad de instrumentos utilizados. Conclusión. La ansiedad, depresión o insomnio afecta negativamente la calidad de vida de las mujeres que se encuentran en alguna de las etapas del envejecimiento reproductivo. Es necesario llevar a cabo más estudios para confirmar nuestros hallazgos. Palabras clave: Envejecimiento reproductivo femenino, menopausia, ansiedad, depresión, insomnio, calidad de vida
La enfermedad periodontal es un factor de riesgo para la enfermedad de Alzheimer
Authors: Hernández-Monjaraz Beatriz
Published: July 2022

Es bien conocido que, para poder comer, es necesario que el cerebro “mande” una señal que active los músculos de la masticación, la lengua, los carillos, etc.; sin embargo, recientemente se ha visto que las señales sensoriales de la mandíbula y los dientes también pueden afectar al cerebro. A esta comunicación bidireccional, entre el cerebro y las estructuras de la boca, se le ha denominado “eje cerebro-estomatognático” e incluye estructuras corticales, subcorticales y los diferentes componentes del sistema estomatognático: dientes, periodonto, lengua, músculos masticatorios, glándulas salivales, maxilares y articulación temporomandibular. Esta red de comunicación entre el cerebro y las estructuras del sistema estomatognático, además de ser bidireccional, es compleja.
¿Es útil la Momordica charantia (melón amargo) para el tratamiento de la Diabetes Mellitus tipo 2?
Authors: Aguiñiga Sánchez Itzen
Published: July 2022

La Diabetes Mellitus tipo 2 (DMT2) es una de las enfermedades metabólicas más comunes en todo el mundo y su desarrollo es causado principalmente por la combinación de dos factores principales: secreción defectuosa de insulina por las células β pancreáticas y la incapacidad de los tejidos sensibles a la insulina para responder a esta, se caracteriza por un aumento de glucosa en sangre, conocida como hiperglucemia. Los efectos nocivos de la hiperglucemia se clasifican en dos partes: complicaciones macrovasculares y microvasculares. Las complicaciones microvasculares incluyen retinopatía, nefropatía, gastroparesia y neuropatía, mientras que las complicaciones macrovasculares incluyen accidente cerebrovascular, enfermedad arterial coronaria, infarto agudo al miocardio y enfermedad arterial periférica. En México para el 2021 la DMT2 ocupó la tercera causa de muerte, superada por la COVID 19 y las enfermedades del corazón, siendo más frecuente en hombres que en mujeres.
An Analysis of Onomatopoeia in the Lion King Movie 2019
Authors: Hidayati Laila Septia , Sesmiyanti Sesmiyanti , Merina Yola
Published: July 2022

Penelian ini dilatarbelakangi oleh keterarikan peneliti untuk mengetahui onomatopoeia yang ada didalam film lion king, dalam penelitian ini peneliti memilih teori Bredin sebagai panduan penelitia panduan peneliti dlam menemukan tipe-tipe onomatopoeia adalah kata-kata yang suaranya mirip dengan suara sebenarnya, memiliki kemiripan akustik (suara atau getaran) dengan suara aslinya. Assosiative onomatopoeia adalah kata-kata onomatopoeisanya karena diasosiasikan seperti tiruan suara hewan. Examplarya adalah kemiripan antara suara dan konsep yang diacu dapat ditemukan dalam implikasi dan ide-ide terkai dan bukan dalam arti sebenarnya seperti yang ditentukan dalam kams. Desain penelian ini adalah kualitatif. Metode penelitian kualitatif merupakan salah satu cara penelitian untuk menghasilkan data descriptive berupa data kata-kata yang tertulis dan lisan dari objek yang diamati dalam penelitian iini . sedangkan peneiti berperan sebagai instrument utama. Dalam penelitian ini, peneliti mengguanakan metode simak dan tekniknya dalam menganalisis data. Data penelitian ini adalah tiruan bunyi yang ada didalam film lion king. Berdasarkan hasil penelitian ini, peneliti menemukan data sebanyak 15 data onomatopoeia, direct onomotopeia, direct onomatopoeia 7 (tujuh), assosiative onomatopoeia 7 (tujuh) dan 1 (satu) exemplary onomatopoeia.Kata kunci : Onomatopoeia, tipe-tipe onomatopoeia.
Kelayakan dan Pratikalitas Web Kudolar Berbasis Android terhadap Kemampuan Siswa Menganalisis Dinamika Atmosfer
Authors: Wulandari Tasya , Juita Erna , Tanamir Momon Dt.
Published: July 2022

The function and use of information and communication technology (ICT) for education has become an irresistible need, information and communication technology in education will function as a storehouse of knowledge. This study aims to determine the analysis, feasibility and practicality of the android-based kudolar web learning media on atmospheric dynamics material and its impact on the life of class X IPS SMAN 2 Bayang. Types of research and development (Research and Development). Using a 4D model consisting of 4 stages, namely 1) Define 2) Design, 3) Development, 4) Desiminate. The subjects in this study were 116 students of class X Social Sciences. The results of the study found that: a) The appropriate learning media based on Android was declared very feasible after analyzing data processing using Microsoft Excel so that a total of 392 were obtained with an average level of 4.56 and a percentage level of 91% in the "very good" category. b) The appropriate learning media based on Android is declared practical after processing the research obtained from the questionnaire, and a practicality test is carried out so that a score of 2786 is obtained with an average level of 4.65 and a percentage of 93% in the "Practical" category.
Students’ Interest on Using Youtube in Learning English
Authors: Suci Putri Ramalia , Yelliza Yelliza , Elmiati Elmiati
Published: July 2022

Penelitian ini dilatarbelakangi oleh keinginan peneliti untuk melihat ketertarikan mahasiswa terhadap penggunaan YouTube dalam belajar bahasa Inggris di Universitas PGRI Sumatera Barat. Penelitian ini adalah penelitian descriptive qualitative method dengan data yang diambil dari angket ketertarikan mahasiswa terhadap penggunaan YouTube dalam belajar bahasa Inggris. Jumlah responden dalam penelitian ini sebanyak 67 mahasiswa pendidikan bahasa Inggris yaitu kelas A dan kelas B tahun ajaran 2020/2021. Penelitian ini menggunakan total sampling dalam pengambilan sample. A structured item questionnaire digunakan sebagai instrumen untuk teknik pengumpulan data. Peneliti mengumpulkan data dengan cara membagikan angket ke 67 mahasiswa melalui Google Form. Hasil analisa data memperlihatkan bahwa  YouTube memberikan faktor yang bagus terhadap ketertarikan mahasiswa. Mahasiswa senang dan tertarik dalam belajar bahasa Inggris menggunakan YouTube, sehingga menstimulasi dan menarik minat mahasiswa dalam belajar bahasa Inggris. Mahasiswa dapat belajar dan mengulang pelajaran menggunakan YouTube di manapun dan kapanpun karena YouTube mudah diakses dan digunakan . YouTube mampu memberikan pelajaran yang ter-update bagi mahasiwa. YouTube juga membantu mahasiswa untuk belajar secara mandiri di rumah. Peneliti menyimpulkan bahwa YouTube memberikan faktor yang baik terhadap minat dan ketertarikan mahasiswa dalam belajar bahasa Inggris.
Pengembangan Game Edukasi Matematika di SDN 02 Sungai Rumbai
Authors: Sidiq Syahrul , Edriati Sofia , Samudra Ami Anggraini
Published: July 2022

ABSTRACT        This research is motivated by the low learning outcomes of students in mathematics subjects and the absence of different learning variations by utilizing learning media. This is one of the reasons for developing Adobe Flash-based educational game media in mathematics. This research is a research and development research that aims to produce a valid and practical development of educational game-based learning media on mathematics material for class II. The development model used in this research is MDLC (Multimedia Development Life Cycle). The development model consists of 6 stages, namely: concept, design, material collection, assembly, testing, distribution. Media validation was carried out by 2 lecturers of the informatics education study program and material validation was carried out by 3 lecturers of the mathematics education study program. Practical data were taken from questionnaires and interviews. The results of testing educational game-based learning media by media validators showed that educational games were very valid with an assessment percentage of 90.66%, educational game assessments by material validators 92% with very valid criteria, practicality assessment by teachers 91.92% with very practical criteria and the results of the second grade student interviews were very interesting and fun. And it can be concluded that Adobe Flash-based educational games are very valid and very practical to use.
Design of Water Supply Scheme: A Case Study of Nangargaon Village
Authors: Kadam Mr. Vidyanand S.
Published: July 2022

Abstract: Design of water supply scheme in around Rural Areas. During classify toward fulfil the water command of the constantly rising population, it is necessary toward supply the plenty with consistent capacity of water through the designed system of pipe. intended for this use the particulars provide via the IPH (Irrigation and Public Health Department) department, the common features of the region similar to in order on the chief water basis, population of the region, insist of water, requirement of the pumps, distribution network and water tanks are essential for efficient design of water distribution system. Water distribution system deals with the supplying of potable water for a village which can be useful for both drinking and wholesome purpose. The main stages of distribution system are collection works, transmission works, purification works and distribution works. It includes estimation of future population (population forecasting) by using various methods, layout of pipes and design of valves and joints, finding out the head losses etc
Design and Simulation of Op-Amp Based Neuron Circuit
Authors: K Padmaja
Published: July 2022

Abstract: Combining CMOS analog spike neurons with memory synapses, neuromorphic chips can provide massively parallel processing and density of neural networks, providing a promising solution for brain inspired computing. This work demonstrates a leaky integral firing neuron design that implements current integral and synaptic driven dualmode operation, and crossbar resistance synaptic enabled in situ learning with a single op amp. The proposed design was implemented with 0.18 μm CMOS technology.
Design and Analysis of Interpretation for Orthopedic Plate with Titanium Alloy
Authors: Murali R. , Rajappan Dr. R.
Published: July 2022

Abstract: The bone is considered as a linear-elastic, isotropic, and homogeneous materials. Trauma is a major cause of death and disability in both developed and developing nations. The mainly consider interpretation of accident after healing orthopaedic surgery plate replacement material design, evaluation, machining and optimization can be consider in this project. In this project setup is simply replacement method for three models of healing plate of single hole, four holes and six holes plate design in Solid Works. Evaluation process used in 3D finite element methods for a fractured bone with three models of titanium alloy plates is analysed using ANSYS workbench.
Mitigating Sink-Hole Attacks for IoT Security using Probe Routing
Authors: B. S Mr. Venkatesh Prasad , Khan Amir Ahmed , K S Bhavani , B Syed Nayamathulla , K R Kavya
Published: July 2022

Abstract: Internet of Things (IoT) applications have been filling altogether as of late, be that as it may, the security issue has not been all around read up in the writing for the IoT environment. The sinkhole assault is one of serious disastrous assaults for IoT as it is not difficult to send off the assault and hard to shield it. In this paper, a Probe Route based Defence Sinkhole Attack (PRDSA) conspires is proposed to oppose Sinkhole assault and assurance security for IoT, which is the primary work that can recognize, sidestep and find the sinkhole simultaneously. The PRDSA plot proposes a directing instrument joining the far-sink invert steering, equivalent bounce steering, and least jump directing, which can successfully evade the sinkhole assaults and track down a protected course to the genuine sink, with the goal that the plan can accomplish better sinkhole discovery. All the more significantly, the PRDSA conspire beats the restriction of past plans that they can't find the sinkhole. During the discovery of the sinkhole assault, the PRDSA plot requires the hubs and the sink hub to return the mark of the data (e.g., IDs, and so on), so the area of the sinkhole not entirely set in stone. Moreover, the PRDAS plot basically uses the qualities of organization energy utilization. The test course of sinkhole assault predominantly happens in the district where the excess energy exists. Subsequently, the PRDSA plot little affects the organization lifetime.
Enhancing the Performance of Android
Authors: Kolle Raunak R , Murthy S Dr. Rajashekara
Published: July 2022

Abstract: In the present day, with the increasing popularity of the android operating system, applications being built on the Android SDK draw much attention. However, some applications built on android tend to have a cumbersome interface causing inconveniences to users. This can be reduced by eliminating the redundancies during the build of these applications. List view is commonly used in android applications to arrange a list of scrollable items in a sequential order. This consumes a considerable amount of memory and CPU utilization resulting in the degradation of the applications. One proposed solution to this can be the introduction of the RecyclerView. The RecyclerView traditionally replaces the GridView and the ListView which were previously used in android applications. This improvement is achieved by recycling the views which are out of the visibility of the user inturn enhancing both the ListView as well as the GridView. Networking in android was previously a nightmare for developers where they had to retrieve and analyze their own data. Data transfer is performed in Android applications using a Web REST API. Development speed can be enhanced by efficient data analysis by utilizing a library from the entire range of REST client libraries. REST (Representational State Transfer) has become the most commonly used way for creating, publishing, and consuming Web services, exploiting JavaScript Object Notation (JSON) as a data exchange format. The most used libraries for accessing the REST Web APIs today are Android Volley and Retrofit. An android device is hindered by limited power, memory and resources. Several architectures such as MVC(Model-View-Controller), MVP(Model-view-Presenter) and MVVM(ModelView-Viewmodel) are commonly used in the development of android applications. In order to develop applications with efficient CPU utilization, reduced memory usage and a lowered execution time, the most suitable of these architectures is to be utilized
Study on Robot Veterinarians
Authors: S Mrs. Indhumathi , R Lekha
Published: July 2022

Abstract: Today’s sensor-driven revolution is reworking robots from rote machines into cognitive collaborators. They have got grow to be a key link in a dynamic continuum that encompasses humans, different machines, and the digital environments in which they perform. Robots have contributed massively to our industries, allowing maximum gadgets, home equipment, transportation and processed foods to be made successfully and affordably. There's no denying that the twenty first century has introduced extraordinary improvements and breakthroughs. Robotics has pop out from fictional films to actual-international eventualities, acting elaborate responsibilities and converting the world we stay in. Current improvements in robotics have supplied several methods wherein robots may be included into human existence. Robot adoption will likely be an important determinant of commercial enterprise productiveness. Robots have the potential to reshape the manner organizations are carried out and are intended to deliver extra automation competencies to the company. The aim of this paper is to review the ideas that how robots can beimplemented and introduced in Veterinary field in India.
Continuous OS Deployment for Servers
Authors: KM Abhishek , Nandi Prof. Somesh
Published: July 2022

Abstract: Operating Systems have been a fundamental component of computer industry and are being constantly updated to keep on par with technological trends. These new releases, however, may have some configurations that can cause miss functioning of hardware it has been installed on. This is especially crucial in case of Mission Critical Servers (MCS) that are heavily employed for large scale applications. Manual testing of the new releases adds another dimension to existing problem especially if numerous install targets are present. In this project, an extreme automation testing solution is developed to completely circumvent woes incurred due to manual testing. The proposed solution also takes care of various corner cases, which otherwise would be difficult to detect.