bluuebunny/crossref_metadata_2025 huggingface dataset:
Analisis Faktor Risiko Maternal terhadap Keluarga Berisiko Stunting
Authors: Permatasari, M.Kes. Dr. Elok , Leersia Yusi Ratnawati  , Ni'mal Baroya  , Globila Nurika  , Farida Wahyu Ningtyias  , Andrei Ramani
Published: April 2023

Background. In 2021, stunting in Indonesia remains high at 24.4%. Indonesian government has a target to decrease stunting prevalence become 14% in 2024. Jember is one of district in East Java with high stunting prevalence 23,4%. First thousand days of life influenced stunting, and maternal risk factor is one of determinants of stunting. In Indonesia was known as 4T, which is Too young, Too old, Too closed and Too much. Objectives. To analyze Maternal Risk Factor (4T) in families at risk of stunting in Jember district, East Java, Indonesia. Method. This research was ecological study by using secondary data with unit of analysis were 286344 families with stunting risk in Jember district. Source data collection using PK21 (Family Data base 2021) and child monitoring status 2019-2021. Data was analyzed by pearson and spearman correlation. Result. Based on Family data base 2021 in Jember showed that there were 84.19% family at risk of stunting. Maternal risk factor (4T) showed: Too young (age of wife < 19 years) 1.18%; Too old (age of wife > 35 years) 52.50%; too close (birth spacing < 2 years) 1.34%; too much (number of birth > 3) 18.03%. And there were corellation between maternal risk factor too young (0,003), too old (0,000), too close (0,000) and too much (0,000) with family at stunting risk. Conclusion. Stunting in Jember remains high and need prevention by reducing maternal risk factor including: too young, too old, too close, and too much.
Keywords: Stunting, Maternal Risk Factor, 4T
MODIFIKASI EDUKASI DAN PENDAMPINGAN GIZI IBU BALITA CEGAH STUNTING MELALUI KEGIATAN “HEALTHY FOOD COOKING CLASS”
Authors: Has Dwi Faqihatus Syarifah , Ariestiningsih Eka Srirahayu , Cahyadi Nur , Rahma Amalia , Mulyani Endah , Zuhro Diah Fauziya
Published: April 2023

Faktor ibu dan pola asuh yang kurang baik terutama pada perilaku dan praktik pemberian makan kepada anak juga menjadi penyebab anak stunting apabila ibu tidak memberikan asupan gizi yang cukup dan baik. Ibu yang masa remajanya kurang nutrisi, bahkan di masa kehamilan, dan laktasi akan sangat berpengaruh pada pertumbuhan tubuh dan otak anak. Penelitian ini bertujuan untuk mengetahui pengaruh modifikasi dan pendampingan gizi ibu balita cegah stunting melalui kegiatan “Healthy Food Cooking Clas”. Desain penelitian ini menggunakan Quasy Eksperimental yang melibatkan 80 responden yang berasal dari ibu balita stunting pada 2 daerah lokus stunting di Kabupaten Gresik yakni Desa Singosari dan Desa Klangonan yang diplih secara secara purposive sampling. Metode yang dilakukan menggunakan metode pemeriksaan antopometri pada balita, penyuluhan nilai gizi produk healthy food, ceramah tanya jawab, demonstrasi dan praktik memasak (cooking class healthy food). Pelaksanaan kegiatan selama 3 bulan, dalam interval 2 mingguan dilaksanakan di balai Desa Singosari dan Klangonan. Hasil kegiatan modifikasi edukasi dan pendampingan gizi ibu balita cegah stunting dengan healthy food cooking class dapat meningkatkan pengetahuan ibu) dan menghasilkan karya menu berupa Bubur Tim Kelor, Eggrol Bandeng Kelor, Dawet Kelor, Es Krim Kelor dan Stik Kelor. Keseluruhan anak balita menyatakan suka dengan rasa, tekstur dan tampilannya. Modifikasi edukasi dengan healthy food cooking class meningkatkan pengetahuan ibu balita dan menarik minat memasak ibu balita untuk cegah stunting. Pemberian edukasi diharapkan dapat bersifat interaktif dengan metode demonstrasi atau praktik.
Komitmen Pimpinan Pada Penurunan Stunting Di Kabupaten Tuban Jawa Timur
Authors: Shofiya Dian , Soesanti Inne , Rachmaniah  , Winarko  , Mujayanto  , Zahrotul Jannah Sa’idah
Published: April 2023

Stunting menyebabkan lemahnya persaingan sumber daya manusia (SDM) suatu negara, karena  selain tampilan fisik juga berdampak pada kemampuan kognitif. Hasil SSGI21 menyatakan prevalensi stunting di Indonesia sebesar 24,4%. Pemerintah menargetkan prevalensi stunting tahun 2024 menjadi 14%. Untuk mencapai angka tersebut memerlukan komitmen ditingkat pusat sampai dengan desa. Tujuan penelitian adalah untuk mengetahui komitmen pemerintah dan masyarakat desa dalam percepatan penurunan stunting. Metode penelitian ini adalah  penelitian kualitatif dengan pendekatan fenomenologi. Focus Group Discusion merupakan cara pengumpulan data secara kualitatif. Partisipan dalam FGD adalah kepala desa dan pamong desa, bidan desa, bidan Puskesmas,  serta anggota TPPS (Tim Percepatan Penurunan Stunting) di tingkat desa. Penelitian dilakukan di 10 desa lokus stunting di Kabupaten Tuban, Jawa Timur. Hasil penelitian menunjukkan bahwa komitmen pimpinan telah ada tetapi belum operasional. Komitmen pendanaan masih bersifat umum belum focus pada balita stunting dan keluarga beresiko stunting, sangat bergantung pada dana pemerintah pusat dan bersumber pada dana desa yang sangat terbatas berupa pemberian makanan tambahan di posyandu. Sumberdaya manusia telah banyak melakukan kegiatan tetapi belum semua terlibat dalam kegiatan percepatan penurunan stunting, misalnya bisang pendidikan dalam hal ini adalah PAUD. Saran yang dapat diberikan agar pimpinan desa melakukan sosialisasi kepada seluruh tim percepatan penurunan stunting, memfokuskan sekaligus menambah besarnya anggaran untuk balita stunting dan keluarga beresiko stunting dan melibatkan semua komponen masyarakat untuk melakukan percepatan penurunan stunting.
 
Kata kunci : stunting, komitmen pimpinan, dana desa.
KEARIFAN LOKAL DALAM PAWON URIP UNTUK PENCEGAHAN STUNTING DI KABUPATEN LUMAJANG JAWA TIMUR
Authors: Ghaffar Muhammad Luthfi Abdul , Riyanto Edi Dwi , Nadhiroh Siti Rahayu , Fatah Mohammad Zainal , Nurmala Ira
Published: April 2023

Stunting dipahami sebagai rendahnya tinggi badan menurut umur pada anak. Indeks gizi tinggi-untuk-usia adalah umum untuk mengukur stunting masa kanak-kanak. Anak stunting tidak selalu kurus, bahkan ada yang kelebihan berat badan dibandingkan tinggi badannya.. Salah satu cara untuk mengatasi stunting adalah dengan memastikan kemanan pangan dan pemenuhan zat gizi secara berkelanjutan. Salah satu cara untuk mewujudkan hal tersebut adalah dengan penerapan Pawon Urip. Pawon Urip merupakan kearifan lokal Kabipaten Lumajang yang didasari oleh konsep kekeluargaan, gotong royong, empati dan juga solidaritas antar warga. Tujuan paper ini adalah menjelaskan bagaimana Pawon Urip di Kabupaten Lumajang Jawa Timur memanfaatkan dan mengembangkan  nilai-nilai kearifan lokal yaitu gotong royong dan solidaritas terhadap masyarakat sekitar untuk mencegah stunting sebagai masalah bersama warga. Paper ini merupakan kajian kualitatif terhadap Pawon Urip. Data utama dikumpulkan dengan cara wawancara yang dilakukan dengan sejumlah pegiat Pawon Urip di Lumajang dan beberapa anggota masyarakat. Selain itu dikumpulkan juga data kegiatan Pawon Urip, data statistic stunting, dan data sekunder lainnya yang terkait. Data dianalisis secara tematik untuk menemukan aspek kearifan lokal dalam menghadapi masalah bersama berupa stunting. Hasil dari penelitian ini adalah penerapan Pawon Urip di Desa Kloposawit membantu masyarakat dalam memenuhi kebutuhan gizi selama pandemi dan dapat mendukung keberlanjutan konsumsi pangan dan peningkatan status gizi Diharapkan paper ini bisa menyajikan contoh praktek baik pencegahan stunting dengan memanfaatkan kearifan lokal.
Penta-helix “Desa Emas” As A Commitment to Accelerate Stunting Reduction in Sumenep Regency, East Java Province
Authors: Fauziah Nuraini , Andayani Qurnia , Ariadi Septi , Koesbardiati Toetik , Praharsena Bayu
Published: April 2023

Desa Emas is Elimination for Stunting in the Village that focuses on action to catalyst the reduction of stunting that carried out in 18 district/city in East Java. This program is initiated requires cooperation in achieving the goals. Collaboration that actively involves various sectors is very important, especially using penta-helix strategy include government, college, community, media mass and business partners to commit the acceleration of the stunting reduction. This study aims to describe the implementation of the penta-helix strategy "Desa Emas" in the perception commitment and stunting reduction in Sumenep Regency, East Java Province. The method used is descriptive qualitative with purposive samples, data obtained through in-depth interviews, observations and FGDs to the staff of the Health District Department, sub-district PLKB, village heads, BUMDES managers, family support teams consisting of midwives, PKK cadres, and family planning cadres in 10 stunting locus villages in Sumenep Regency. The results showed that the Sumenep Regency Government had optimized the policies that were prepared with cooperation support of government officials until the village level, media mass, business partner, community, and academic support. The national support for stunting reduction is very important, because of that the action plan of penta-helix strategy is needed to support a commitment to accelerate the stunting reduction sustainability.
Keywords: Penta-helix, Commitment, Stunting, Desa Emas
Determinant of Adherence to iron supplementation in Adolescent Girl In Spesific Intervention For Stunting Prevention: Systematic Review
Authors: Feriyanti Alma , Deviatin Nafiatus Sintya , Nurmala Ira , Widati Sri , Atmaka Dominikus Raditya
Published: April 2023

An increase in the prevalence of anemia in young women will affect the quality of life and their offspring. Adolescent girls who experience anemia are at risk for anemia during pregnancy. Anemia in pregnant women will impact giving birth to stunted babies. Iron supplementation is a specific intervention effort to prevent anemia in female adolescents. This study aims to analyze the determinants of adherence to iron supplementation in young women and specific interventions to prevent stunting. This study uses a systematic review using PRISMA. Five electronic databases are used: Scopus, ScienceDirect, Wos, SAGE, and Google Scholar. The articles used in this research are 10 articles. The inclusion criteria for this study were articles published within five years, namely, 2018-2022, full text, open access, and in Indonesian and English. The determinants of adherence to iron supplementation are influenced by several factors, including sociodemographic factors such as the mother's occupation, education, and adolescent age. Intrapersonal factors such as young women's motivation and perceived benefits. Interpersonal factors such as support from parents, peers, and teachers. Institutional factors such as school support in the distribution of iron tablets. The compliance of young women in consuming iron tablets is influenced by sociodemographic, intrapersonal, intrapersonal, and institutional factors. There is a need for health education for young women and parents as well as strengthening commitment to schools so that they receive support in the implementation of iron supplementation as a specific intervention for stunting prevention
 
Keywords: Compliance, Iron Tablets, Adolescents, Anemia, Stunting
Exploring Bifidobacterium species community and functional variations with human gut microbiome structure and health beyond infancy
Authors: Ladeira Ruben , Tap Julien , Derrien Muriel
Published: April 2023

Aim: The human gut Bifidobacterium community has been studied in detail in infants and following dietary interventions in adults. However, the variability of the distribution of Bifidobacterium species and intra-species functions have been little studied, particularly beyond infancy. Here, we explore the ecology of Bifidobacterium communities in a large public dataset of human gut metagenomes, mostly corresponding to adults. Methods: We selected 9.515 unique gut metagenomes from curatedMetagenomicData. Samples were partitioned by applying Dirichlet’s multinomial mixture to Bifidobacterium species. A functional analysis was performed on > 2.000 human-associated Bifidobacterium metagenome-assembled genomes (MAGs) paired with participant gut microbiome and health features. Results: We identified several Bifidobacterium-based partitions in the human gut microbiome differing in terms of the presence and abundance of Bifidobacterium species. The partitions enriched in both B. longum and B. adolescentis were associated with gut microbiome diversity and a higher abundance of butyrate producers and were more prevalent in healthy individuals. B. bifidum MAGs harboring a set of genes potentially related to phages were more prevalent in partitions associated with a lower gut microbiome diversity and were genetically more closely related. Conclusion: This study expands our knowledge of the ecology and variability of the Bifidobacterium community, particularly in adults, and its specific association with the gut microbiota and health. Its findings may guide the rational selection of Bifidobacterium strains for gut microbiome complementation according to the individual’s endogenous Bifidobacterium community. Our results also suggest that gut microbiome stratification for particular genera may be relevant for studies of variations of species and associations with the gut microbiome and health.
Natural Frequencies of a Viscoelastic Supported Axially Functionally Graded Bar With Tip Masses
Authors: Demir Cihan
Published: April 2023

The frequency parameters of an Axially Functionally Graded (AFG) bar for viscoelastic and point mass boundary conditions are studied in this paper. The structures with functionally graded materials under axial loads can be modelled as AFG bars. Those may be considered as support elements with spring and dashpot in the vibration isolation. Keeping the ratio of force frequency and natural frequency at a certain level is ensured to control the natural frequency therefore dynamic amplification factor with different material combinations. Various boundary conditions are attained by changing the spring and damping coefficients of viscoelastic support elements and the ratio of rod mass to tip mass. Researchers assume that the beam material properties in directions of length and thickness change exponentially, individually, or both in their studies. There are a few studies on the AFG rods in the existing studies. Analysis is carried out via the finite element method for the non-dimensional frequency parameters of the bar in MATLAB. The energy equations of the motion are obtained in the frame of axial bar theory considering the material properties of the bar vary longitudinally according to the power-law distribution. The effects of material distribution, spring, damping and tip mass values on the bar's frequency parameters and structural behaviour have been extensively investigated.
Improving Ride Comfort of a Soil Compactor based on the NSS Embedded into the Seat's Semiactive Suspension
Authors: Jiang Jinyu , Min Lujian , Jing Yang , Ding Shiding , Yu Machun , Jie Wangxiang
Published: April 2023

Three dynamic models (1-D, 2-D, and 3-D) of a soil compactor are established to research the vehicle's ride comfort via numerical simulation and experiment. Based on the efficiency of the semi-active control (SAC) of the Fuzzy-PID controller and the negative stiffness structure (NSS), a new suspension of the driver's seat equipped with the SAC and NSS is proposed to further improve the soil compactor's ride comfort under the various working conditions of the vehicle on the elastoplastic soil ground. The reduction of the root-mean-square seat acceleration (a_ws) in the time domain and the power-spectral-density seat acceleration (PSD) in the frequency domain is chosen as the objective function. The study indicates that the seat's acceleration response in the time domain with the 1-D, 2-D, and 3-D models of the soil compactor is similar. However, the a_ws and maximum PSD acceleration of the driver's seat with the 1-D model are higher than that of the 3-D model by 35.9% and 58.5%, while the acceleration response and PSD acceleration of the driver's seat with the simulation of the 3-D model are similar to the experiment. Therefore, the different dynamic models of the vehicle remarkably affect the investigation result. With the driver's seat suspension equipped with the SAC and NSS, the $a_{ws$ and maximum PSD acceleration of the driver's seat are strongly decreased by 80.1% and 87.6% compared to the seat's passive suspension without the SAC and NSS. Additionally, these values are also lower than that of oth the SAC and NSS under various simulation conditions. Consequently, the driver's seat suspension equipped with the SAC and NSS could be used to further improve the ride comfort of the soil compactor.
Surfaces Intersection and Flattening in 3D Models Through Computer Extended Descriptive Geometry (CeDG)
Authors: Prado-Velasco Manuel , García-Ruesgas Laura
Published: April 2023

Computer extended Descriptive Geometry (CeDG) is a new approach to solve and build computer models of three dimensional (3D) geometrical systems through descriptive geometry procedures that have demonstrated reliability and accuracy. CeDG may calculate a parametric algebraic exact form for the spatial curves generated in the intersection of two surfaces, as well as of the flattened pattern of any developable surface involved in those encounters. This study presents first the theoretical foundations and methodology to calculate those parametric algebraic curves. Secondly, a compound hopper is defined and modelled through CeDG (implemented in GeoGebra) and CAD (Solid Edge 2023) approaches to evaluate the advantages of CeDG against CAD. The results demonstrate the robustness and accuracy of the CeDG technique for surfaces intersection and flattening and the advantages of CeDG against Solid Edge 2023 in solving the hopper case study.
Robust and Fragile Determinants of the Severity of Covid-19 in Developing and Developed Countries: A Comparative Analysis
Authors: Moosa Imad A. , Khatatbeh Ibrahim N.
Published: April 2023

By using the Sala-i-Martin version of extreme bounds analysis, which is based on the cumulative density function, cross-sectional evidence is presented on the robust determinants of the infection and case mortality rates of Covid-19. The results show that, for most part, different factors determine the infection and mortality rates in developed and developing countries. However, common factors are also apparent, including the risk environment, the number of tests per million and the percentage of population over 65. Notwithstanding the possibility that the official data represent a partial reflection of the truth, it is concluded that the results presented in this study provide useful information that may aid decision-making in the fight against the pandemic.
Neurological Disease Modeling Using Pluripotent and Multipotent Stem Cells: A Key Step Towards Understanding and Treating Mucopolysaccharidoses
Authors: Carvalho Sofia , Santos Juliana Inês , Moreira Luciana , Gonçalves Mariana , David Hugo , Matos Liliana , Encarnação Marisa , Alves Sandra , Coutinho Maria Francisca
Published: April 2023

Despite extensive research, the links between the accumulation of glycosaminoglycans (GAGs) and the clinical features seen in patients suffering from various forms of Mucopolysaccharidoses (MPSs) have yet to be further elucidated. This is particularly true for the neuropathology of these disorders, even though the neurological symptoms are currently incurable, even in the cases where a dis-ease-specific therapeutic approach does exist. One of the best ways to get insights on the molecular mechanisms driving that pathogenesis is the analysis of patient-derived cells. Yet, not every pa-tient-derived cell holds potential to recapitulate relevant disease features. For the neurodegenerative forms of these diseases in particular, it is challenging to grow neuronal cultures that accurately represent them because of the obvious inability to access live neurons. This scenario changed sig-nificantly since Yamanaka et al. published their protocol for induction of pluripotent stem cells (SC) from adult human fibroblasts. From then on, a series of differentiation protocols to generate neurons from induced pluripotent stem cells (iPSC) was developed and extensively used for disease mod-eling. Currently, human iPSC and iPSC-derived cell models have been generated for several MPS and numerous lessons were learnt from their analysis. Here we review most of those studies, not only listing the currently available MPS iPSC lines and their derived models, but also summarizing how they were generated and the major information different groups have gathered from their analysis. Finally, and taking into account that iPSC generation is a laborious/expensive protocol that holds significant limitations, we also comment on a tempting alternative to establish MPS pa-tient-derived neuronal cells in a much more expedite way by taking advantage of the existence of a population of multipotent SC in human dental pulp, to establish mixed neuronal and glial cultures.
Eudaimonic Well-Being of Italian Young Adults during the COVID-19 Pandemic: The Role of Psychological Inflexibility and Fear of Death
Authors: Calvo Vincenzo , Masaro Chiara , Fusco Chiara , Pellicelli Camilla , Ghedin Simona , Marogna Cristina
Published: April 2023

The COVID-19 pandemic has had a profound impact on the mental health, adjustment, and psychological well-being of young adults. Despite extensive research conducted in this area, eudaimonic well-being, one specific form of psychological well-being focusing on self-knowledge and self-realization within existential challenges, has received comparatively less attention. The current study aimed to investigate the potential linkages between two key psychological factors, psychological inflexibility and fear of death, with eudaimonic well-being among young adults in the context of the Covid-19 pandemic. One year after the outbreak, 317 young Italian adults (18-34 yrs.) participated in an online survey, including measures of psychological inflexibility (AAQ-II), fear of death (CL-FODS), and eudaimonic well-being (PWB). Results showed that psychological inflexibility was negatively associated with all the dimensions of Ryff’s model of eudaimonic well-being, while fear of death of others was found to be associated with three of these dimensions (autonomy, environmental mastery, and self-acceptance). Results also indicated a mediation role of psychological inflexibility in the association between fear of death and eudaimonic well-being. These findings expand our knowledge of the potential factors that may influence eudaimonic well-being and provide insights for clinical work with young adults challenged by uncertain times.
Analisis Pengembangan Ekspor Pala, Lawang, dan Kapulaga Indonesia
Authors:   Institute for Development of Economics and Finance, Nurhayati Ely , Hartoyo Sri ,   Departemen Ilmu Ekonomi, Fakultas Ekonomi dan Manajemen, Institut Pertanian Bogor, Mulatsih Sri ,   Departemen Ilmu Ekonomi, Fakultas Ekonomi dan Manajemen, Institut Pertanian Bogor
Published: April 2023

Ekspor merupakan komponen penting dalam perekonomian. Semakin tinggi kinerja ekspor, semakin besar pula dampak positifnya. Sejak 2012 hingga 2016, ekspor Indonesia terus menurun sehingga Indonesia perlu meningkatkan kembali ekspornya. Salah satu komoditas yang potensial dikembangkan adalah pala, lawang, dan kapulaga. Penelitian ini menganalisis daya saing pala, lawang, dan kapulaga, serta faktor yang memengaruhi ekspornya. Metode yang digunakan adalah RCA, EPD, X-Model, dan Gravity. Hasil analisis daya saing menunjukkan bahwa pasar ekspor yang optimis adalah Pakistan, Jerman, Italia, dan Amerika Serikat. Pasar ekspor yang potensial adalah Malaysia, Vietnam, Thailand, Prancis, dan Belanda. Faktor yang memengaruhi ekspor adalah PDB per kapita, harga, jarak ekonomi, dan tarif.
Aktivitas Ekspor dan Inefisiensi Teknis Industri Andalan Ekspor Indonesia
Authors:   Program Pascasarjana Ilmu Ekonomi, Fakultas Ekonomi dan Bisnis Universitas Indonesia, Rustiawati Rika BettyNurindah , Lubis Andi Fahmi ,   Program Pascasarjana Ilmu Ekonomi, Fakultas Ekonomi dan Bisnis Universitas Indonesia
Published: April 2023

Penelitian ini meneliti bagaimana pengaruh aktivitas ekspor terhadap inefisiensi teknis pada industri andalan ekspor Indonesia dengan menggunakan data level perusahaan yang bersumber dari Survei Industri Besar Sedang BPS periode 2010 sampai dengan 2014. Penelitian ini menggunakan model stochastic frontier dengan one step approach yang diterapkan pada fungsi produksi translog. Hasil dari penelitian ini adalah aktivitas ekspor berpengaruh terhadap tingkat efisiensi perusahaan, yang mana industri yang tergolong dalam industri dengan tingkat teknologi rendah memiliki tingkat inefisiensi yang lebih rendah dibandingkan industri dengan tingkat teknologi tinggi.
PENGEMBANGAN MODEL PROGRAM PEMBELAJARAN INDIVIDU (PPI) BAGI ANAK BERKEBUTUHAN KHUSUS DI SEKOLAH DASAR INKLUSIF KOTA METRO
Authors: Perdana Ryzal
Published: April 2023

Development of Individual Learning Program (PPI) Model for Children with Special Needs in Inclusive Primary Schools in Metro City. The purpose of this research is to analyze and describe the policy of inclusive education in Metro City through the provision of good services and implementation facilities, to increase the competence of special companion teachers for children with special needs, to produce a model for developing Individual Learning Programs for children with special needs in primary schools that provide inclusive education. Produce graduate masters in education management on time. This study uses a research and development, method which is a research method used to produce a lesson plan (RPP) product. The method used is Research and Development (R & D) with a qualitative approach with a descriptive type. Primary and secondary data sources were obtained from informants selected purposively based on their mastery of inclusive education service management. This research was conducted for four months. This research includes research by the research team lecturers in the form of Individual Learning Program Model Development for Children with Special Needs in Inclusive Elementary Schools in Metro City with postgraduate students of the education management study program FKIP University of Lampung as guidance. The results of this study were addressed to the Metro City Government through the Education and Culture Office as a learning material tool(legal draft)of the individual learning program (PPI) model for children with special needs (ABK) through special companion teachers (GPK) in elementary schools (SD) of Metro City.
Pengaruh Motivasi Berprestasi dan Stres terhadap Prestasi Akademik Mahasiswa Tahap Akademik Kelas Internasional Program Studi Pendidikan dan Profesi Dokter Fakultas Kedokteran Universitas Indonesia
Authors: Afdhal Yogie
Published: April 2023

The purpose of this study was to know correlation between achievement motivation and stress on the academic achievement of international class student Faculty Medicine Universitas Indonesia. Total 64 of 176 students were used as research samples to obtain data then analyzed using the quantitative method of path analysis. The result of this study indicate that (1) there is a positive correlation between achievement motivation and academic achievement, (2) there is a negative correlation between stress and academic achievement, (3) there is a negative correlation between achievement motivation and stress.
Kesuksesan Muslimah Pelaku UMKM: Peran Dimensi Entrepreneurial Orientation
Authors: Supriyanto Agus , Permatasari Ririt Dwiputri , Prihastuti Asepma Hygi , Saputra Tommy , Bora M. Ansyar
Published: April 2023

The purpose of this study was to determine the factors that support the success of Muslim women in running a business seen from the dimensions of entrepreneurial orientation. Respondents in the study were 105 Muslim SMEs who run businesses in Kudus Regency. The sampling technique uses Simple Random Sampling with the Convenience Sampling method. The data analysis technique uses Structural Equation Modeling with the help of AMOS 25.0. The results of the study indicate that there is a significant influence between innovation, risk taking, proactivity, competitive aggressiveness and autonomy on the birth of Muslim women as MSME actors. All dimensions of entrepreneurial orientation are proof that to achieve success in running a business, a business actor needs to implement the dimensions of entrepreneurial orientation. The autonomy dimension gets the highest average answer, it is important to pay attention that the delegation of authority and responsibility to employees to make accidental decisions. The managerial implication of this research is that SMEs need to pay attention to the dimensions of entrepreneurial orientation because it will have an impact on improving business performance.
TAPHONOMIC SIGNATURES IN DEAD SHELLS OF THE INVASIVE GASTROPOD RAPANA VENOSA (VALENCIENNES, 1846) AFTER TWO DECADES IN THE RÍO DE LA PLATA, URUGUAY
Authors: GÓMEZ-MADURO MARÍA CECILIA , ROJAS ALEJANDRA , MARTÍNEZ SERGIO
Published: April 2023

Rapana venosa (Valenciennes, 1846) is an invasive gastropod, the arrival of which in the Río de La Plata estuary 22 years ago is well-documented. Rapana venosa shells were collected during two sampling events from four beaches with different substrate types and wave energy regimes to compare the taphonomic attributes under different environmental conditions. We analyzed the samples by comparing frequencies of taphonomic attributes. Our results show that intermediate-reflective beaches with rocky substrates were dominated by intermediate- to highly fragmented specimens, with high corrasion, intermediate to high bioerosion, low bioencrustation, and medium to large sizes. In contrast, intermediate-dissipative beaches with sandy substrate, mobile stones, and occasional consolidated sediments were dominated by less fragmented shells, high to intermediate corrasion, scarcer bioerosion, low bioencrustation, and small- to medium-sized specimens. Results suggest that significant taphonomic differences arise within two decades under natural conditions. These findings imply that paleoenvironmental signals derived from the taphonomic attributes of fossil assemblages emerge much faster than the potential duration of time averaging of shelly fossils in shallow marine settings.
Diagnostic imaging to locate elements lost during the development of a surgery: A cohort study.
Authors: Susmallian Sergio , Szyper-Kravitz Martine , Folv Eduard , Barnea Royi
Published: April 2023

Object: To corroborate the efficiency of diagnostic images to find missed surgical elements during the course of an operation. Background: Over time, surgery has become more complex, which has increased the risk of events in which surgical items are lost. An incomplete instrumental table inventory can affect patient safety. Material and Methods: Over 6 years, 145 cases of missed surgical items were reported; in 69 (47.6%) cases, a diagnostic image was indicated to search for surgical missed items events (SMIE). Statistical results and significant cases are presented. Mean patients age was 56.81 years old, and 70.7% were female. Results: General surgery was the specialty, and needles were the most frequent items lost. The prevalence of the X-ray image to locate a foreign body was 46.5%, sensitivity was 50%, specificity 100%, and accuracy 76.9%. A total of 14 (21.5%) complications were registered, and no death occurred. In this study, four cases of SMIE are presented to demonstrate a severity of the medical error. Conclusions: An abnormal inventory count and missing objects are indications to conduct diagnostic imaging in the operation room. In the case of a negative X-ray diagnosis, the team should continue searching for the missing object, including re-opening the operating cavity. Clinicaltrials.gov (NCT04293536), date of registration: March 3, 2020.
Estimation Atmospheric parameters for Weather Study and Forecast over Equatorial Regions Using Ground-Based Global Position System
Authors: Yehun Asmamaw Chanie , Kassa Tsegaye , Hunegnaw Addisu , Vermeer Martin
Published: April 2023

There are various models to estimate the neutral atmospheric parameter values, such as in-suite and reanalysis datasets from numerical models. Accurate estimated values of the atmospheric parameters are useful for weather forecasting and climate modeling and monitoring of climate change. Recently, Global Navigation Satellite System (GNSS) measurements have been applied for atmospheric sounding due to its robust data quality and wide horizontal and vertical coverage. The Global Positioning System (GPS) solutions that includes tropospheric parameters constitute a reliable set of data to be assimilated into climate models. The objective of this paper is, to estimate the neutral atmospheric parameters such as Wet Zenith Delay (WZD), Precipitable Water Vapour (PWV) and Total Zenith Delay (TZD) using six selected GPS stations in the equatorial regions, more precisely the Ethiopian GPS stations from 2012 to 2015 observational data. Based on historic estimated GPS-derived values of PWV, we forecasted the PWV from 2015 to 2030. During data processing and analysis, we applied GAMIT-GLOBK software packages to estimate the atmospheric parameters. In the result, we found that the annual averaged minimum values of PWV are 9.72 mm for IISC and maximum 50.37 mm for BJCO stations. The annual averaged minimum values of WZD are 6 cm for IISC and maximum 31 cm for BDMT stations. In the long series of observations (from 2012 to 2015), we also found that there is a trend and cyclic patterns of WZD, PWV and TZD for all stations.
UCHL1 facilitates protein aggregates clearance to enhance neural stem cell activation in spinal cord injury
Authors: Ding Lu , Chu Weiwei , Xia Yu , Ming Shi , Li Tian , Zhou Feng-Quan , Deng David
Published: April 2023

Activation of endogenous neural stem cells (NSCs) is greatly significant for the adult neurogenesis, which is extremely limited in the non-neurogenic spinal cord after injury. Recent evidence suggests that accumulation of protein aggregates impairs the ability of quiescent NSCs to activate. Ubiquitin c-terminal hydrolase l-1 (UCHL1), an important deubiquitinating enzyme in ubiquitin system, plays critical role in removing protein aggregations, but its effects on NSC activation remains unknown. Here, we show that UCHL1 enhances NSC activation by clearing protein aggregates through ubiquitin-proteasome approach. Upregulation of UCHL1 ameliorated the proliferation of spinal cord NSCs after spinal cord injury (SCI). Based on protein microarray analysis of SCI cerebrospinal fluid, it is further revealed that C3+ neurotoxic reactive astrocytes negatively regulated UCHL1 and proteasome activity via C3/C3aR signaling, led to increased abundances of protein aggregations and decreased capacity of NSCs to activate. Furthermore, blockade of reactive astrocytes or C3/C3aR pathway resulted in enhanced NSC activation post-SCI by reserving UCHL1 and proteasome functions. Together, this study elucidated a mechanism regulating NSC activation in the adult spinal cord involving the UCHL1-proteasome approach, which may provide potential molecular targets and new insights for NSC fate regulation.
A novel molecular switch controls assembly of bacterial focal adhesions
Authors: Mignot Tam , Attia Bouchra , My Laetitia , Castaing Jean Philippe , Dinet Celine , Guenno Hugo Le , Schmidt Victoria , Espinosa Leon , Anantharaman Vivek , Aravind L , Sebban-Kreuzer Corinne , Nouailler Matthieu , Bornet Olivier , Viollier Patrick , Elantak Latifa
Published: April 2023

Cell motility is universally driven by focal adhesion complexes (FAs) assembled in the cell envelope to connect the underlying substrate to cytoskeletal motors, generating traction forces in a highly regulated manner. In bacteria, focal adhesion complexes (bFAs) assembly is mediated by the Agl-Glt motility machinery, however how this machinery is connected to the cytoskeleton via cytoplasmic platform proteins, MglA and AglZ, remains unknown. Here, combining in vitro and single cell approaches, we show that the cytoplasmic region of the transmembrane GltJ protein contains two cytosolic motifs that independently recruit MglA-GTP (Linker) and AglZ (GYF), thus driving bFA assembly. Remarkably, binding of MglA-GTP causes a switch in the conformation of an adjacent Zinc finger domain (ZnR) that becomes available to recruit MglB, a MglA GTPase-Activating Protein. This binding activates GTP hydrolysis, which dissociates MglA from GltJ and is important to regulate bFA stability in vivo. These findings thus unravel the molecular mechanism of bFA assembly and regulation. Remarkably, the large number of other bacterial receptor proteins containing adjacent GYF and ZnR domains suggests conservation of this novel type of molecular switches.
Establishment of RT-RPA-Cas12a assay for rapid and sensitive detection of human rhinovirus B
Authors: Li Yongdong , Wang Xuefei , Xu Rong , Wang Ting , Zhang Dandan , qian Weidong
Published: April 2023

Human rhinovirus B (HRV-B) is a major human viral pathogen that can be responsible for various kinds of infections. Due to the health risks associated with HRV-B, it is therefore crucial to explore a rapid, specific, and sensitive method for water quality surveillance. Herein, we exploited a novel detection method for HRV-B by combining reverse-transcription recombinase polymerase amplification (RT-RPA) of nucleic acids isothermal amplification and the trans-cleavage activity of Cas12a. Our RT-RPA-Cas12a-based fluorescent assay can be completed within 35–45 min and obtain a lower detection threshold to 0.5 copies/µL of target RNA. Meanwhile, crRNA sequences without a specific protospacer adjacent motif can effectively activate the trans-cleavage activity of Cas12a. Moreover, our RT-RPA-Cas12a-based fluorescent method was examined using 30 clinical samples, and exhibited high accuracy with positive and negative predictive agreement of 90% and 100%, respectively. Taken together, a novel promising, rapid and effective RT-RPA-Cas12a-based detection method was explored and shows promising potential for on-site HRV-B infection in resource-limited settings.
Whole genome bisulfite sequencing of tumor DNA and matching cfDNA in relapsed pediatric cancer
Authors: Buckley David , Tew Ben , Gooden Gerald , Salhia Bodour
Published: April 2023

Cancer is the second most common cause of death in children aged 1-14 years in the United States, with 11,000 new cases and 1,200 deaths annually. Pediatric cancers typically have lower mutational burden compared to adult-onset cancers; however, the epigenomes of pediatric cancer are highly altered with widespread DNA methylation changes. Currently, whole genome bisulfite sequencing (WGBS) is the most powerful tool for methylome evaluation, but it has been infrequently used to study pediatric cancers. In this we performed WGBS on 34 relapsed pediatric tumors, 13 patient-matched adjacent normal, and 17 patient-matched cell-free (cf)DNA samples from plasma, representing 11 pediatric tumor types. DNA methylation analysis of these cancers revealed differentially methylated regions common to multiple tumor types, which were also detectible in cfDNA and showed potential relevance in multiple adult cancer types. In addition, WGBS data was utilized to estimate copy number alterations (CNAs) and somatic mutations. We also found that tumor associated cfDNA methylation was more sensitive than detection of circulating CNAs and somatic mutations. The resultant pan-cancer cfDNA methylation signature has potential utility in minimal residual disease monitoring and warrants further investigation in both pediatric and adult cancer.
Tooth brushing with fluoridated toothpaste and associated factors among Chinese adolescents: a nationwide cross- sectional study
Authors: Cui Zhiying , Wang Wenhui , Si Yan , Wang Xing , Feng Xiping , Tai Baojun , Hu Deyu , Lin Huancai , Wang Bo , Wang Chunxiao , Zheng Shuguo , Liu Xuenan , Rong Wensheng , Wang Weijian
Published: April 2023

Background: Tooth brushing with fluoridated toothpaste has become the most important way to provide the anti-caries effect of fluoride around the world. China has promoted the use of fluoridated toothpaste since 1989. However, there are few studies on the national profile of use of fluoridated toothpaste and related factors in Chinese adolescents. We carried out this study to investigate oral hygiene behaviours, especially the status of tooth brushing with fluoridated toothpaste and its correlates among adolescents, based on data from the latest Nation Oral Health Survey in mainland China.
Methods: This cross-sectional study recruited 118,601 subjects aged 12-15 years using multistage stratified sampling. Questionnaires were completed by students at school. Data employed in analyses were extracted from the questionnaire, including information on tooth brushing, fluoridated toothpaste, dental floss, sociodemographic factors, fluoride knowledge and attitude towards regular dental care. A binary logistic regression was performed to compute the odds ratios (OR). Tooth brushing twice daily with fluoridated toothpaste was the dependent variable. Sociodemographic factors, fluoride knowledge, attitude towards regular dental care, dental visit experience and perceived oral health were the independent variables. P < 0.05 was considered statistically significant.
Results: A total of 32.6% of subjects brushed their teeth twice daily, 7.4% used fluoridated toothpaste, and 3.9% cleaned their teeth twice daily with fluoridated toothpaste. The logistic regression showed the probability of twice-a-day tooth brushing with fluoridated toothpaste was higher among these groups: females (OR: 1.141; 95%CI: 1.072-1.214), 15-year-olds (OR: 1.786; 95%CI: 1.634-1.952), from urban areas (OR: 1.389; 95%CI: 1.288-1.497), without siblings (OR: 1.351; 95%CI: 1.259-1.450), with an educated father (OR: 1. 605; 95%CI: 1.442-1.788) and mother (OR: 1.706; 95%CI: 1.530-1.903), having dental visit experiences (OR: 1.702; 95%CI: 1.589-1.823), rating one’s oral health as good (OR: 2.341; 95%CI: 2.083-2.631), having fluoride knowledge (OR: 4.345; 95%CI: 4.034-4.678) and having a positive attitude towards regular dental care (OR: 1.589; 95%CI: 1.460-1.729).
Conclusions: The oral hygiene behaviours of Chinese adolescents were undesirable. Twice daily tooth brushing with fluoridated toothpaste was significantly associated with sociodemographic factors, fluoride knowledge, and attitudes towards regular dental care.
Incidence and Determinants of Mortality among Adult Patients Taking Antiretroviral Therapy in Ethiopia: Systematic Review and Meta-Analysis
Authors: Lijalem Habtamu , Workie Shimelash Bitew , Gutulo Muluken Gunta , (professor  , Mazengia Amare Lisanu , Toma Eshetu Hizkeal , Endeshaw Amanual Sisay
Published: April 2023

Reduced AIDS mortality has been linked to the advent of highly active antiretroviral medication. The previous reviews conducted in Ethiopia lack the overall rigor and clarity in the study methodology, reported results and statistical inference. The goal was to create a data summary from studies accomplished previously throughout the nation so that programmers and implementers could use to harmonize the current advanced intervention and direct health service providers to improve ART service provision packages. This data would provide a thorough update on the magnitude of mortality among HIV-infected patients taking HAART by combining 21 eligible articles. The study's heterogeneity, publication bias, and quality were examined. The statistical analysis used random-effects model in STATA version 14. The protocol was registered(CRD42019123380).
As a result, the pooled mortality incidence was 5 per 100 person-years of observation (95% CI: 4–5 per 100 pyo). Two-thirds of deaths occurred within the first year of starting HAART. Clinical stage (Pooled HR = 3.15; 95% CI: 2.36–4.21), CD4 count (Pooled HR = 2.31; 95% CI: 1.83–2.93), hemoglobin level (Pooled HR = 3.05; 95% CI: 2.19–4.27), TB co-infection (Pooled HR = 3.08; 95% CI: 2.21–4.29), and functional status (Pooled HR = 4.86; 95% CI: 3.59–6.97) were factors in this study that were substantially linked to higher mortality. Mortality rates were high, especially early in the therapeutic process. Significant mortality risk factors were WHO clinical stage, CD4 count, poor hemoglobin, TB co-infection, and non-working functional status. This significant mortality rate could be avoided with comprehensive care and stringent monitoring.
The semisynthetic cannabinoid Hexahydrocannabinol (HHC)
Authors: Russo Fabiana , Vandelli Maria Angela , Biagini Giuseppe , Schmid Martin , Luongo Livio , Perrone Michela , Ricciardi Federica , Maione Sabatino , Laganà Aldo , Capriotti Anna Laura , Gallo Alfonso , Carbone Luigi , Perrone Elisabetta , Gigli Giuseppe , Cannazza Giuseppe , Citti Cinzia
Published: April 2023

Cannabis is a double-faced plant with uncountable therapeutic properties, on one side, and controversial psychotropic activities, on the other side, modulated by CB1 endocannabinoid receptors. Δ9-Tetrahydrocannabinol (Δ9-THC) has been identified as the main component responsible for the psychotropic effects, while its isomer cannabidiol (CBD) has shown completely different pharmacological properties. Based on the remarkable beneficial effects, Cannabis has spread worldwide and it is openly sold in shops and online. In order to overcome restrictions due to legal issues, nowadays semi-synthetic derivatives of CBD are often added to cannabis products, obtaining “high” effects similar to those given by Δ9-THC. The first semi-synthetic cannabinoid appeared in the EU was obtained by cyclization and hydrogenation of CBD, and known as hexahydrocannabinol (HHC). At present, very little is known about HHC, its pharmacological properties, and diffusion, since it is not commonly investigated in routine toxicological assays. In the present work, the synthetic strategies aimed to obtain an excess of the active epimer of HHC were investigated and the two epimers were purified and individually tested for their cannabinomimetic activity. Lastly, a simple and fast chromatographic method with a UV detector and a high-resolution mass spectrometer was applied to identify and quantify up to ten major phytocannabinoids, as well as the HHC epimers in commercial cannabis samples.