bluuebunny/crossref_metadata_2025 huggingface dataset:
The new mineral tomiolloite, Al12(Te4+O3)5[(SO3)0.5(SO4)0.5](OH)24: A unique microporous tellurite structure
Authors: Missen Owen P. , Mills Stuart J. , Rumsey Michael S. , Spratt John , Najorka Jens , Kampf Anthony R. , Thorne Brent
Published: January 2022

Tomiolloite (IMA2021-019) is a new aluminum tellurite sulfite-sulfate mineral discovered at the Bambolla mine, Moctezuma, Sonora, Mexico, a well-known tellurium (Te) mineral locality. Tomiolloite forms roughly spherical clusters of crystals comprised of very thin, needle-like crystals (1 μm diameter, ~40 μm length) around a core of small, stubbier, broken crystals. Tomiolloite is generally found growing on tellurite or quartz. The strongest powder X-ray diffraction lines are [dobs Å (Iobs) (hkl)]: 11.667 (89) (100), 8.240 (38) (101), 4.107 (29) (202,211,121), 3.223 (100) (203,302,130), and 2.905 (37) (213,123,222,400). The empirical formula of tomiolloite, as determined by electron microprobe analysis, is (Al10.64Te1.016+Fe0.313+Zn0.04)Σ12(Te5.004+Pb0.02)Σ5.02(S0.494+S0.496+Si0.02)Σ1.00O21.53[(OH)20.86Cl0.11]Σ20.97, which is simplified to the ideal formula Al12(Te4+O3)5[(SO3)0.5(SO4)0.5](OH)24. Significant Te6+ substitution for Al3+ is observed in tomiolloite, verified by X-ray photoelectron spectroscopy and crystal-structure analysis. The structure of tomiolloite was determined using synchrotron single-crystal X-ray diffraction, showing that tomiolloite is hexagonal and crystallizes in the space-group P63/m, with the unit-cell parameters a = 13.3360(19) Å, c = 11.604(2) Å, V = 1787.3(6) Å3, and Z = 2. Tomiolloite has a unique microporous framework structure, which bears a slight similarity to that of zemannite, but it has a much larger cavity diameter (8.85 Å). The framework is built from edge-sharing Mφ6 octahedra (M = Al3+ and Te6+), Te4+O3 trigonal pyramids, and Te4+O4 disphenoids. Mφ6 octahedra edge-share to form crankshaft-shaped chains along c, with Te4+On polyhedra filling notches in the crankshafts and providing linkages between adjacent chains. The framework has an overall positive charge, which is balanced by the presence of both sulfite (SO32−) trigonal pyramids and sulfate (SO42−) tetrahedra in the channels.
¿Los riesgos de suicidio y eutanasia están cubiertos en el contrato de seguro?
Authors: Torres Gamero Rolando
Published: January 2022

El presente trabajo busca establecer cómo las figuras del suicidio y la eutanasia como riesgos dentro del contrato de seguro están o no cubiertos generalmente en los seguros de vida y afines, si bien es cierto la naturaleza de esta cobertura es indemnizar a los beneficiarios de aquellos asegurados que pierden la vida por enfermedad (en forma natural) o por accidente (debidamente probado); el suicidio y la eutanasia vienen a ser unas formas de fallecimiento cuya muerte no está originariamente contemplada pero si de manera posterior, como en el caso del suicidio, como lo prevé nuestra Ley del Contrato de Seguro en el Perú promulgada en noviembre de 2012.
La educación en el Perú en tiempos de pandemia Covid-19
Authors: Orbegoso Rivera Viky , Rafael Hidalgo Bertha Luz , Moreno Chinchay Lily Rocío
Published: January 2022

El presente artículo nos permite observar como la educación debe ser vista como un derecho y que ha estado presente en el transcurso de la historia constitucional de nuestro país como un sueño anhelado por muchas generaciones; así mismo la pandemia ocasionada por el SARS-CoV-2 nos ha demostrado que no estamos preparados para adaptarnos a los nuevos cambios que trae consigo la tecnología, la ciencia y los tiempos que vivimos, pero sobre todo nos muestra el gran reto que debemos asumir en nuestra labor Docente. Frente a este panorama hacemos una reflexión sobre cómo enfrentar a esos nuevos retos que nos trae ya el presente siglo XXI. Partimos de la base legal en el aspecto educativo, donde la educación debe concebirse como un derecho, se habla también de la gratuidad de la enseñanza en todos los niveles educativos y la ansiada calidad educativa que tanto añoramos. Además, hablamos de la educación en el espacio virtual en el Perú donde SÍ es posible desarrollar contenidos actitudinales, incluso proponemos un método y estrategias en el marco de la Educación remota. Finalmente concluimos que si bien la pandemia de la Covid-19 ha acrecentado aún más la brecha digital, trayendo consigo grandes desventajas, también ha hecho posible ver este panorama como la oportunidad para demostrar que con esfuerzo, dedicación, autoaprendizaje y compromiso podemos contrarrestar dichos efectos, transformando nuestras debilidades en oportunidades.
Evolución Disruptiva de las Microfinanzas en el Perú
Authors: Toledo Concha Emerson
Published: January 2022

Las entidades especializadas en el otorgamiento de créditos a la micro y la pequeña empresa en el Perú, están orientadas a realizar cambios disruptivos y acelerados en sus procesos con el fin de generar eficiencia financiera en sus indicadores. Son conscientes, que se enfrentan a un verdadero tsunami de cambios  en esta industria masiva, donde cada vez más,  el desarrollo tecnológico, la transformación digital,  el uso de la big data y de las herramientas analíticas,  impulsan hacia un cambio revolucionario que tienen que hacer estas entidades para reinventarse y enfrentar los nuevos desafíos en un entorno mucho más competitivo, generado por la sobreoferta de instituciones microfinancieras y la entrada de nuevos “jugadores”, que ha llevado a  reducciones  de tasas de interés, a un aumento en las provisiones de créditos  y aún, la mayoría de estas entidades tradicionales,  no pueden controlar los costos operativos que por naturaleza son altos en este sector. Por lo tanto este trabajo muestra que el continuismo de los modelos que funcionaron al inicio pueden llegar a ser en el corto plazo, cuestionados o ser obsoletos en sus procesos y aplicaciones, por lo que, en base a este nuevo contexto puedan cambiar su  enfoque de gestión y liderazgo.
Adaptation of Mindfulness in Parenting Questionnaire (MIPQ) for parents of children aged 2-12 years
Authors: Febriani Zulfa , Setyowati Retno Budi , Kumalasari Dewi , Fourianalistyawati Endang
Published: January 2022

Mindful parenting intervention programs and trait can support positive parenting conditions and affect children's psychosocial development. However, the measurement of mindful parenting has not been widely developed. The Mindfulness in Parenting Questionnaire (MIPQ) scale is one approach that has been developed; it is considered to have good psychological properties and has been validated in several countries. This study aims to find evidence for the validity of the Indonesian version of the MIPQ score interpretation (MIPQ-Ind) in a population of parents of children aged 2-12 years. The total participants are 822 parents (268 fathers and 554 mothers) who live in Jakarta. Using the split sample technique and employing EFA and CFA tests, the research results show that the MIPQ-Ind has two valid factors, as indicated by the index χ2/df= 2.8, CFI= 0.9, GFI= 0.96 RMSEA= 0.06, and RMSR = 0.04. The internal structure validity is 0.913 for being in the moment with child (BMC) factor and 0.906 for the mindful discipline (MD) factor. The study shows that MIPQ-Ind can measure mindful parenting in the population of parents of children aged 2-12 years in Indonesia.
Children’s and adolescents’ reports on their quality of life during the COVID-19 pandemic
Authors: Borualogo Ihsana Sabriani , Casas Ferran
Published: January 2022

COVID-19 has had a significant impact on human life, yet very limited studies have investigated the quality of life (QoL) of children and adolescents during the pandemic. This paper aims to present the reports of children and adolescents (N = 1,474; 10–18 years old) on their QoL during the COVID-19 pandemic in Indonesia. Data were collected using Google Forms and convenience sampling. The instruments measured the five domains of QoL: material, physical, social, emotional, and productive well-being. The data were analyzed descriptively using mean scores, crosstab, frequency, and ANOVA. The results show that the children and adolescents maintained their level of subjective well-being (SWB) and adapted to adverse situations during the lockdown. Boys and younger children displayed significantly higher mean scores than girls and older children. Children and adolescents reported boredom due to a lack of various physical activities, dissatisfaction with school closures, the things they learned at home, and their contact with friends. This study has implications in terms of providing advice to parents, teachers, children, and adolescents for promoting the QoL of children and adolescents during the pandemic.
Examining gender role attitude as a moderator of personality, social support, and childcare responsibilities in women’s work-life balance
Authors: Shaleh Abdul Rahman , Nuraini Putri
Published: January 2022

The participation of women in the workforce creates challenges and problems. Those with various roles in their lives must be good at playing and balancing these successfully. This study focuses on the work-life balance factor by exploring the predictor factors including personality, family social support, and childcare responsibilities, as moderated by gender role attitude. A work/ nonwork interference and enhancement scale, mini-IPIP, gender role beliefs scale, and social support scale were developed for the data collection. A sample of 220 married female workers was identified using purposive sampling. The data analysis, which used multiple regression and a modgraph, shows a significant effect of personality, social support, and childcare responsibilities on the work-life balance moderated by gender role attitude. Four independent variables with significant influence are neuroticism, openness to experiencing family support, gender role attitude and there is a moderating effect on neuroticism and family support. The implication is the need to provide a comfortable work environment and arrangement of work patterns so that women's work-life balance can be achieved positively.
Undergraduate Student Course Perceptions in Response to Pedagogically Different Approaches in Introductory Anatomy and Physiology
Authors: Adams Jessica
Published: January 2022

Our institution underwent a curricular revision to change the course approach for introductory anatomy and physiology courses from separate, discipline-specific human anatomy and human physiology courses to an integrated A&P I and A&P II course approach. Through a mixed-methods exploratory study, this research sought to determine undergraduate student perceptions of anatomy through this curricular revision. Data was collected through word associations, open-ended surveys, and course evaluation data. Our results indicate that undergraduate student perceptions of anatomy changed between the first course and the second course in the sequence, rather than between course approaches. Students in both course approaches reported similar interests, confusions, and difficulties related to anatomy education, and an awareness of the explicit and implicit curriculum was evident in student responses. However, some specific evaluation prompts exhibited a significant difference between course approaches. Results from this perception study can guide practitioners to consider the curricular context and unique challenges of anatomy and physiology students in meeting the expectations of the health care field.
The Effect of Cooperative Quizzes on Student Performance and Anxiety in Community College Human Physiology Courses
Authors: Bell Kathy , Gerrits Ron , Hood Suzanne
Published: January 2022

Community college students come from a variety of backgrounds and have different levels of educational preparedness compared to undergraduates in 4-year undergraduate schools. Historically, retention rates of these students in human physiology courses have been low, often due to non-passing grades. Incorporation of additional active learning techniques has the potential to benefit learning in this group, which might ultimately benefit retention. However, active learning activities need to be incorporated in a thoughtful manner, because some activities can increase anxiety in students, resulting in unintended consequences such as student withdrawal from such activities. This study introduced cooperative quizzes into community college human physiology classes to determine if they improved student exam performance and reduced student anxiety. The cooperative quizzes were intended to be given in face-to-face classes but were adapted for synchronous broadcast classes using Zoom due to the COVID-19 pandemic. In the sample of students studied, cooperative quizzes did not have a significant impact on exam grades. However, several students reported a preference for the cooperative quizzes over traditional quizzes. In addition, the intervention did not increase the reported anxiety scores among students, which adds support for the use of cooperative quizzes as an active learning strategy in STEM classes.
Fundamentos de una nueva política forestal para el Perú
Authors: Dourojeanni Marc J. , Malleux Jorge , Sabogal César , Lombardi Ignacio , Tarazona Roger , Rincón Carlos , Scheuch Helmut , Barriga César A.
Published: January 2022

Se presentan los fundamentos de una nueva política para los bosques del Perú como respuesta a su situación, marcada por la deforestación y la degradación, su insignificante aporte al PBI y su incapacidad de abastecer la demanda nacional, a pesar de que los bosques cubren la mayor parte del territorio nacional. Varias políticas, estrategias y planes, así como cinco leyes no resolvieron la situación. Por eso, se propone una reforma radical del sector, incluyendo un enfoque integral y transectorial, como única forma de abordar la deforestación, indicando responsabilidades específi[1]cas de los sectores agrario y de transporte; una nueva definición de patrimonio forestal nacional excluyendo del mismo las llamadas tierras de aptitud forestal y, por ende, descartando el anacrónico concepto de clasificación de tierras por capacidad de uso mayor. Las tierras con bosques naturales no podrán sufrir cambio de uso. En cambio, se propone que el sector agrario titule los campesinos asentados en las tierras de aptitud forestal ya deforestadas y que se acelere el proceso en curso de reconocimiento y titulación de comunidades nativas y campesinas. Además, se propone que ese sector lidere un proceso de intensificación del uso de la tierra ya deforestada mediante el aumento de la productividad agropecuaria. Se determina que la función primordial del patrimonio forestal nacional es la provisión de servicios ambientales y no, como hasta el presente, la producción de madera. Por tanto, se devuelve al Estado la responsabilidad del manejo forestal, ahora encargada a los que aprovechan el recurso forestal. Para asegurar el abastecimiento de madera se estimularán las plantaciones forestales y se propone una serie de medidas políticas y económicas para que éstas, además de suplir la demanda de madera, se conviertan en el motor de la economía y asimismo, contribuyan a aliviar los graves problemas de degradación ambiental. Entre otras medidas se pro[1]ponen cambios en el tratamiento de la fauna silvestre. Se fortifica el apoyo técnico y financiero a los pobladores rurales y a las comunidades nativas y campesinas, para darles mejores oportunidades de aprovechar sosteniblemente los recursos forestales, en parte gracias a la renta generada por los servicios ecosistémicos que proveen. Eso presupone mudanzas importantes en la administración del patrimonio nacional forestal proponiéndose la creación de un Ministerio de los Recursos Natu[1]rales Renovables pero el mantenimiento de la silvicultura en el sector agrario, la promulgación de una nueva ley forestal y de leyes especiales para atender la silvicultura, la fauna silvestre, la titulación de tierras, entre otras. Se trata asimismo de temas de educación, investigación y, finalmente, el de la corrupción en el sector forestal.
Molecules Containing Cyclobutyl Fragments as Therapeutic Tools: A
Review on Cyclobutyl Drugs
Authors: Ren Shuang , Pan Fei , Zhang Wen , Rao Guo-Wu
Published: January 2022

In recent years, cyclobutyl has become more influential in the field of drug design.
Its unique four-membered ring structure is not only a useful intermediate for the
synthesis of biomedical candidate materials but also an indispensable framework for drug
design and application. According to the therapeutic field, cyclobutyl drugs are roughly
divided into tumor and cancer drugs, nervous system drugs, analgesics, antiviral drugs,
and gastrointestinal drugs. Among them, platinum-based anticancer drugs containing cyclobutyl
fragments have achieved remarkable success in the treatment of cancer, bringing
new hope for the development of more cyclobutyl drugs. This article provides details of
the research progress of the structure types, structure-activity relationships, targets, and
mechanisms of cyclobutyl drugs that have been on the market or are in the clinical stage
and provides ideas for the discovery and synthesis of novel cyclobutyl-containing drugs.
The Crosstalk between Gut Microbiota, Intestinal Immunological Niche and Visceral Adipose Tissue as a New Model for the Pathogenesis of Metabolic and Inflammatory Diseases: The Paradigm of Type 2 Diabetes Mellitus
Authors: Cianci Rossella , Franza Laura , Massaro Maria Grazia , Borriello Raffaele , Tota Antonio , Pallozzi Maria , De Vito Francesco , Gambassi Giovanni
Published: January 2022

Gut microbiota (GM) comprises more than one thousand microorganisms between bacterial species, viruses, fungi, and protozoa and represents the main actor of a wide net of molecular interactions, involving, among others, the endocrine system, immune responses, and metabolism. GM influences many endocrine functions, such as adrenal steroidogenesis, thyroid function, sexual hormones, IGF-1 pathway and peptides, produced in the gastrointestinal system. It is fundamental in glycaemic control and obesity, while also exerting an important function in modulating the immune system and associated inflammatory disease. The result of this crosstalk in gut mucosa is the formation of the intestinal immunological niche. Visceral adipose tissue (VAT) produces about 600 different peptides and it is involved in lipid and glucose metabolism, and some immune reactions, through several adipokines. GM and VAT interact in a bidirectional fashion: while gut dysbiosis can modify VAT adipokines and hormone secretion, VAT hyperplasia modifies GM composition. Acquired or genetic factors leading to gut dysbiosis or increasing VAT (i.e., Western diet) induce a pro-inflammatory condition, which plays a pivotal role in the development of dysmetabolic and immunologic conditions, such as diabetes mellitus. Diabetes is associated with specific patterns of GM alterations, an abundance or reduction of GM species involved in controlling mucosal barrier status, glycaemic levels and exerting a pro- or anti-inflammatory activity. All these factors could explain the higher incidence of several inflammatory conditions in Western countries; furthermore, besides the specific alterations observed in diabetes, this paradigm could represent a common pathway acting in many metabolic conditions and could pave the way to new, interesting therapeutic approaches.
Nanoparticle Mediated Gene Therapy: A Trailblazer Armament to
Fight CNS Disorders
Authors: Annu  , Rehman Saleha , Nabi Bushra , Sartaj Ali , Md Shadab , Sahoo PK , Baboota Sanjula , Ali Javed
Published: January 2022

Central nervous system (CNS) disorders account for boundless socioeconomic
burdens with devastating effects among the population, especially the elderly. The major
symptoms of these disorders are neurodegeneration, neuroinflammation, and cognitive
dysfunction caused by inherited genetic mutations or by genetic and epigenetic changes
due to injury, environmental factors, and disease-related events. Currently available clinical
treatments for CNS diseases, i.e., Alzheimer’s disease, Parkinson’s disease, stroke,
and brain tumor, have significant side effects and are largely unable to halt the clinical
progression. So gene therapy displays a new paradigm in the treatment of these disorders
with some modalities, varying from the suppression of endogenous genes to the expression
of exogenous genes. Both viral and non-viral vectors are commonly used for gene
therapy. Viral vectors are quite effective but associated with severe side effects, like immunogenicity
and carcinogenicity, and poor target cell specificity. Thus, non-viral vectors,
mainly nanotherapeutics like nanoparticles (NPs), turn out to be a realistic approach
in gene therapy, achieving higher efficacy. NPs demonstrate a new avenue in pharmacotherapy
for the delivery of drugs or genes to their selective cells or tissue, thus providing
concentrated and constant drug delivery to targeted tissues, minimizing systemic
toxicity and side effects. The current review will emphasize the role of NPs in mediating
gene therapy for CNS disorders treatment. Moreover, the challenges and perspectives of
NPs in gene therapy will be summarized.
Eosinophils Restrict Diesel Exhaust Particles-induced Cell Proliferation of Lung Epithelial A549 Cells via Interleukin-13 Mediated Mechanisms: Implications for Tissue Remodeling and Fibrosis
Authors: Niranjan Rituraj , Muthukumaravel Subramanian , Panneer Devaraju , Ojha Sanjay Kumar
Published: January 2022

Background:

Diesel exhaust particles (DEPs) affect lung physiology and cause serious damage to the lungs. A number of studies demonstrated that eosinophils play a very important role in the development of tissue remodeling and fibrosis of the lungs. However, the exact mechanism of pathogenesis of tissue remodeling and fibrosis is not known.

Methods:

Both in vitro and in vivo models were used in the study. HL-60 and A549 cells were also utilized in the study. 8 to 12 weeks old BALB/c mice were used for the in vivo study. Cell viability by MTT assay and RNA isolation by tri reagent was accomplished. mRNA expression of inflammatory genes was accomplished by real-time PCR or qPCR. Immunohistochemistry was done to assess the localization and expressions of proteins. One-way ANOVA followed by a post hoc test was done for the statistical analysis. Graph-Pad prism 5 software was used for statistical analysis.

Results:

Altogether, we elucidated the mechanistic role of eosinophils and IL-13 in the DEP-triggered proliferation of lungs cells, thus providing an insight into the pathophysiology of tissue remodeling and fibrosis of lungs.

Conclusion:

Altogether, we elucidated, the mechanistic role of eosinophils and IL-13 in the DEP-triggered proliferation of lungs cells thus providing an inside in the pathophysiology of tissue remodelling and fibrosis of lungs.
Antinociceptive Effects of Aza-Bicyclic Isoxazoline-Acylhydrazone Derivatives
in Different Models of Nociception in Mice
Authors: Mota Fernanda Virginia Barreto , Coutinho Felipe Neves , de Carvalho Vanessa Mylenna Florêncio , de Assis Correia Julyanne Cunha , Bastos Isla Vanessa Gomes Alves , Marcelino-Neto Pedro Paulo , Ximenes Rafael Matos , Brondani Dalci José , de Faria Antônio Rodolfo , Marchand Pascal , da Silva Teresinha Gonçalves
Published: January 2022

Background:

In a study recently published by our research group, the isoxazoline-acylhydrazone
derivatives R-99 and R-123 presented promising antinociceptive activity. However, the
mechanism of action of this compound is still unknown.

Objective:

This study aimed to assess the mechanisms involved in the antinociceptive activity of these
compounds in chemical models of pain.

Methods:

Animals were orally pretreated and evaluated in the acetic acid-, formalin-, capsaicin-,
carrageenan- and Complete Freund's Adjuvant (CFA)-induced pain models in mice. The effects of
the compounds after pretreatment with naloxone, prazosin, yohimbine, atropine, L-arginine, or
glibenclamide were studied, using the acetic acid-induced writhing test to verify the possible involvement
of opioid, α1-adrenergic, α2-adrenergic or cholinergic receptors, and nitric oxide or potassium
channels pathways, respectively.

Results:

R-99 and R-123 compounds showed significant antinociceptive activity on pain models induced
by acetic acid, formalin, and capsaicin. Both compounds decreased the mechanical hyperalgesia
induced by carrageenan or CFA in mice. The antinociceptive effects of R-99 and R-123 on
the acetic acid-induced writhing test were significantly attenuated by pretreatment with naloxone,
yohimbine or atropine. R-99 also showed an attenuated response after pretreatment with atropine
and glibenclamide. However, on the pretreatment with prazosin, there was no change in the animals'
response to both compounds.

Conclusion:

R-99 and R-123 showed antinociceptive effects related to mechanisms that involve, at
least in part, interaction with the opioid and adrenergic systems and TRPV1 pathways. The compound
R-99 also interacts with the cholinergic pathways and potassium channels.
Structural-activity Relationship of Metallo-aminoquines as Next
Generation Antimalarials
Authors: Abid Mohammad , Singh Shailja , Egan Timothy J. , Joshi Mukesh C.
Published: January 2022

Apicomplexian parasite of the genus Plasmodium is the causative agent of malaria, one of
the most devastating, furious and common infectious disease throughout the world. According to the
latest World malaria report, there were 229 million cases of malaria in 2019 majorly consist of children
under 5 years of age. Some of known analogues viz. quinine, quinoline-containing compounds
have been used for last century in the clinical treatment of malaria. Past few decades witnessed the
emergence of multi-drug resistance (MDR) strains of Plasmodium species to existing antimalarials
pressing the need for new drug candidates. Thus, in those decades bioorganometallic approach to
malaria therapy has been introduced which led to the discovery of noval metalcontaining aminoquinolines
analogues viz. ferroquine (FQ or 1), Ruthenoquine (RQ or 2) and other related potent metalanalogues.
It observed that some metal containing analogues (Fe-, Rh-, Ru-, Re-, Au-, Zn-, Cr-, Pd-,
Sn-, Cd-, Ir-, Co-, Cu-, and Mn-aminoquines) were more potent; however, some were equally potent
as Chloroquine (CQ) and 1. This is probably due to the intertion of metals in the CQ via various approaches,
which might be a very attractive strategy to develop a SAR of novel metal containing antimalarials.
Thus, this review aim to summarize the SAR of metal containing aminoquines towards the
discovery of potent antimalarial hybrids to provide an insight for rational designs of more effective
and less toxic metal containing amonoquines.
Recent Developments of Coumarin-based Hybrids in Drug Discovery
Authors: Xia Dongguo , Liu Hao , Cheng Xiang , Maraswami Manikantha , Chen Yiting , Lv Xianhai
Published: January 2022

Coumarin scaffold is a highly significant O-heterocycle, namely benzopyran-2-ones,
which form an elite class of naturally occurring compounds with promising therapeutic perspectives.
Based on its broad spectrum of biological activities, the privileged coumarin scaffold is applied
to medicinal and pharmacological treatments by several rational design strategies and approaches.
Structure-activity relationships of the coumarin-based hybrids with various bioactivity
fragments revealed significant information toward the further development of highly potent and selective
disorder therapeutic agents. The molecular docking studies between coumarins and critical
therapeutic enzymes demonstrated a mode of action by forming noncovalent interactions with
more than one receptor, further rationally confirming information about structure-activity relationships.
This review summarizes recent developments related to coumarin-based hybrids with other
pharmacophores aiming at numerous feasible therapeutic enzymatic targets in order to combat various
therapeutic fields, including anticancer, antimicrobic, anti-Alzheimer, anti-inflammatory activities.
COVID-19 Infection in Pregnancy: A Review
Authors: Mily Sabrina Jahan , Akter Kazi Mahmuda , Jabin Nowshin , Mitra Saikat , Emran Talha Bin , Nandi Monisha , Baral Sumit Kumar , Uddin Md. Zia , Mallick Jewel , Paul Arkajyoti , Shah Syed Uzair Ali , Rauf Abdur , Khan Ishaq N. , Mubarak Mohammad S.
Published: January 2022

Coronavirus disease 2019 (COVID-19), which is a highly contagious viral illness caused by
the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has had a catastrophic effect on
the world's demographics, resulting in more than 3.8 million deaths worldwide and establishing itself as
the most serious global health crisis since the 1918 influenza pandemic. Several questions remain unanswered
regarding the effects of COVID-19 disease during pregnancy. Although most infections are mild
in high-risk populations, the severe disease frequently leads to intubation, intensive care unit admission,
and, in some cases, death. Hormonal and physiological changes in the immune and respiratory systems,
cardiovascular function, and coagulation may affect the progression of COVID-19 disease in pregnancy.
However, the consequences of coronavirus infection on implantation, fetal growth and development,
labor, and newborn health have yet to be determined, and, consequently, a coordinated global effort is
needed in this respect. Principles of management concerning COVID-19 in pregnancy include early
isolation, aggressive infection control procedures, oxygen therapy, avoidance of fluid overload, consideration
of empiric antibiotics (secondary to bacterial infection risk), laboratory testing for the virus and
co-infection, fetal and uterine contraction monitoring, prevention, and / or treatment of thromboembolism
early mechanical ventilation for progressive respiratory failure, individualized delivery planning,
and a team-based approach with multispecialty consultations. This review focuses on COVID-19 during
pregnancy, its management, and the area where further investigations are needed to reduce the risk to
mothers and their newborns.
Recent Advances in Combretastatin A-4 Inspired Inhibitors of Tubulin
Polymerization: An Update
Authors: Baytas Sultan Nacak
Published: January 2022

Cancer is one of the leading causes of fatality and mortality worldwide. Investigations
on developing therapeutic strategies for cancer are supported throughout the
world. The massive achievements in molecular sciences involving biochemistry, molecular
chemistry, medicine, and pharmacy, and high throughput techniques such as genomics
and proteomics have helped create new potential drug targets for cancer treatment.
Microtubules are very attractive targets for cancer therapy because of the crucial
roles they play in cell division. In recent years, lots of efforts have been put into the identification
of new microtubule-targeting agents (MTAs) in anticancer therapy. Combretastatin
A-4 (CA-4) is a natural compound that binds to microtubules’ colchicine binding
site and inhibits microtubule polymerization. Due to CA-4’s structural simplicity, many
analogs have been synthesized. This article summarises the new molecule development
efforts to reach CA-4 analogues by pharmacophore group modifications, which have
been reported since 2015.
Telemedicine and Teleconsulting in the Era of COVID-19 Pandemic: A Useful Tool from Screening to Intensive Care Monitoring
Authors: Abete Raffaele , Vecchi Andrea Lorenzo , Iacovoni Attilio , Mortara Andrea , Senni Michele
Published: January 2022

The COVID-19 global pandemic has had striking effects on clinical practice and medical assistance and the progressive evolution of telemedicine and telehealth systems has allowed healthcare professionals to connect with patients yet respecting the striking need for social distancing. This article aims to review the possible ways to use telehealth and teleconsulting systems to guarantee an adequate level of clinical assistance starting from screening procedures up to support the management of patients admitted to intensive care units area, thus balancing the need to ensure continuity of care and at the same time limiting the possible sources of contagion expansion. Telemedicine may be a useful tool to improve clinical assistance and reduce the financial burden on the health system in a long-term view. Although it cannot completely replace patient-physician interactions, it would be desirable to implement this field and made it accessible to the largest part of the population.
Self-Assessment of Biomedical Activity Related to Medical Devices Embedded in EMS Ambulances: Towards a Roadmap for an Efficient Improvement
Authors: Moussaid Abdelghani , Bouaouine Hassan , Ngote Nabil
Published: January 2022

Objective:

The present investigation is focused on a self-assessment of the biomedical activity related to embedded Medical Devices on board a fleet of 46 EMS medicalized ambulances, according to the High Authority of Health standard (criterion 8K) and the Guide of the Good Practices of Biomedical Engineering.

Materials and Methods:

The methodology adopted for this purpose is based on an analysis allowing the evaluation and observation of practices related to biomedical activity in these ambulances. An initial assessment, carried out in March 2021, made it possible to measure the gaps between the actual situation and the recommendations of the two self-diagnosis tools (High Authority of Health and Guide of the Good Practices of Biomedical Engineering standards). A series of corrective actions were proposed and then implemented. A second self-assessment took place after 6 months, in October 2021.

Results:

Between March and October 2021, an improvement in the scores for almost all the axes of the two self-assessment tools was noted. Indeed, the score of the self-assessment for the High Authority of Health reference system rose from 44% in March 2021 to 63% in October 2021, i.e. an increase of 19%, and that of the Guide of the Good Practices of Biomedical Engineering increased from 67.54% in March 2021 to 80.96% in October 2021, i.e. an increase of 13.42%.

Conclusion:

The implementation of a maintenance strategy integrating the notion of quality, relevant procedures and pertinent work tools has made it possible to significantly improve the biomedical activity within the medical ambulances and to optimise the embedded medical devices.
Identifying the Most Successful Formula 1 Drivers in the Turbo Era
Authors: Piquero Alex R. , Piquero Nicole L. , Han Sungil
Published: January 2022

Background:

Formula 1 is the world’s fastest auto racing circuit and one that is among the most-watched of all televised sports. With its international flair and glamor and the glitz it brings to viewers and spectators, it is no surprise that fans, commentators, and media covering the races enjoy ranking the most successful teams and especially the most successful drivers of all time. Yet, there are few empirical studies that have developed and/or applied rigorous methodological techniques to examine which drivers are the most successful within the recent turbo-hybrid era.

Objective:

This study uses novel group-based trajectory methods to rank the most successful drivers within the turbo area, 2014-2019.

Methods:

Group-based trajectory methods are used to identify distinct groups of drivers according to accumulated points.

Results:

Using total points accumulated during each respective season as our measure of success, results showed that the 45 drivers who competed during this time period could be classified into three groups, with the top-performing group of drivers being Lewis Hamilton and Nico Rosberg. A second better-performing group of six drivers followed and included Bottas, LeClerc, Räikkönen, Ricciardo, Verstappen, and Vettel. The remaining 37 drivers were classified into a third low-performing group, a great number of which scored zero points during the time period.

Conclusion:

The most successful Formula 1 drivers during the turbo era were able to be identified using group-based trajectory modeling, with Lewis Hamilton and Nico Rosberg identified as the best drivers based on accumulated points.
Antinociceptive Investigations of Niranthin in Complete Freund’s Adjuvant-
induced Chronic Pain in Mice
Authors: Chopade Atul R. , Salunkhe Vijay R. , Patil Pramod A. , Burade Madhav R. , Somade Prakash M. , Mali Suraj N. , Pandey Anima
Published: January 2022

The main objectives of the present work are to determine the clinical effect of niranthin
on visceral or somatic inflammatory pain. The study was performed to determine the effects of niranthin
on visceral or somatic inflammatory hypersensitivity of adult Swiss albino mice by using
complete Freund’s adjuvant (CFA) induced pain model. The effect of CFA injection was determined
after 24 hours of injection by using an aesthesiometer such as Von Frey filaments to evaluate
tactile acetone-evoked cooling and thermal sensitivity. We used a digital Plethysmometer to
measure paw edema. Single dose of niranthin intraperitoneal injection (5 and 10 mg/kg) was injected
into mice having CFA-induced mechanical hypersensitivity and after 30 minutes of administration,
reduced mechanical hypersensitivity was observed. In addition, niranthin also reduced acetone-
evoked hypersensitivity within 4 hours. Compared to DMSO, niranthin was most highly active
to reduce CFA-induced paw edema. To reduce mechanical hypersensitivity, multiple doses of
niranthin (bis in die (b.i.d.)) from 1st - 5th day and b.i.d. day 9th and 10th) were given and remarkable
results were observed such as did not cause tolerance in multiple dosing and significantly reduced
in CFA induced hypersensitivity. This work reported niranthin having antinociceptive activity and
indicated that niranthin is conventionally active in the management of persistent pain.
Moderating emotional intelligence and religiusity on the effect of burnout on turnover intentions of tax consultant employees in Bali
Authors: Astuti Luh Citra Wirya , Dwirandra A A N B , Astika Ida Bagus Putra , Wirajaya I Gde Ary
Published: January 2022

The purpose of this study was to analyze the effect of burnout on the turnover intentions of tax consultant employees in Bali with emotional intelligence and religiosity as moderating variables. The location of the research was carried out at the Tax Consultant Office in the Bali Region as a representation of the Tax Consultant Office in Indonesia, which was registered with the Indonesian Tax Consultant Association (IKPI) in 2021 which was obtained through the website www.ikpi.or.id. The population in this study are all employees who work at the Tax Consultant Office registered at IKPI Bali Branch. The data analysis technique used the MRA test. The results of the study indicate that burnout has a positive and significant effect on turnover intention or in other words, increased burnout will increase turnover intention. The higher emotional intelligence is not able to reduce the high turnover intention due to the increased burnout of tax consultant employees. The interaction between burnout and emotional intelligence has a negative and significant effect on turnover intention or in other words, high emotional intelligence will reduce turnover intention due to increased burnout.
HIV Surveillance and Research for Migrant Populations: Protocol Integrating Respondent-Driven Sampling, Case Finding, and Medicolegal Services for Venezuelans Living in Colombia
Authors: Wirtz Andrea L , Page Kathleen R , Stevenson Megan , Guillén José Rafael , Ortíz Jennifer , López Jhon Jairo , Ramírez Jhon Fredy , Quijano Cindy , Vela Alejandra , Moreno Yessenia , Rigual Francisco , Case James , Hakim Avi J , Hladik Wolfgang , Spiegel Paul B
Published: January 2022

Background

Epidemiologic research among migrant populations is limited by logistical, methodological, and ethical challenges, but it is necessary for informing public health and humanitarian programming.

Objective

We describe a methodology to estimate HIV prevalence among Venezuelan migrants in Colombia.

Methods

Respondent-driven sampling, a nonprobability sampling method, was selected for attributes of reaching highly networked populations without sampling frames and analytic methods that permit estimation of population parameters. Respondent-driven sampling was modified to permit electronic referral of peers via SMS text messaging and WhatsApp. Participants complete sociobehavioral surveys and rapid HIV and syphilis screening tests with confirmatory testing. HIV treatment is not available for migrants who have entered Colombia through irregular pathways; thus, medicolegal services integrated into posttest counseling provide staff lawyers and legal assistance to participants diagnosed with HIV or syphilis for sustained access to treatment through the national health system. Case finding is integrated into respondent-driven sampling to allow partner referral. This study is implemented by a local community-based organization providing HIV support services and related legal services for Venezuelans in Colombia.

Results

Data collection was launched in 4 cities in July and August 2021. As of November 2021, 3105 of the target 6100 participants were enrolled, with enrollment expected to end by February/March 2022.

Conclusions

Tailored methods that combine community-led efforts with innovations in sampling and linkage to care can aid in advancing health research for migrant and displaced populations. Worldwide trends in displacement and migration underscore the value of improved methods for translation to humanitarian and public health programming.

International Registered Report Identifier (IRRID)

DERR1-10.2196/36026
Developing a Machine Learning Model to Predict Severe Chronic Obstructive Pulmonary Disease Exacerbations: Retrospective Cohort Study (Preprint)
Authors: Zeng Siyang , Arjomandi Mehrdad , Tong Yao , Liao Zachary C , Luo Gang
Published: January 2022

BACKGROUND

Chronic obstructive pulmonary disease (COPD) poses a large burden on health care. Severe COPD exacerbations require emergency department visits or inpatient stays, often cause an irreversible decline in lung function and health status, and account for 90.3% of the total medical cost related to COPD. Many severe COPD exacerbations are deemed preventable with appropriate outpatient care. Current models for predicting severe COPD exacerbations lack accuracy, making it difficult to effectively target patients at high risk for preventive care management to reduce severe COPD exacerbations and improve outcomes.

OBJECTIVE

The aim of this study is to develop a more accurate model to predict severe COPD exacerbations.

METHODS

We examined all patients with COPD who visited the University of Washington Medicine facilities between 2011 and 2019 and identified 278 candidate features. By performing secondary analysis on 43,576 University of Washington Medicine data instances from 2011 to 2019, we created a machine learning model to predict severe COPD exacerbations in the next year for patients with COPD.

RESULTS

The final model had an area under the receiver operating characteristic curve of 0.866. When using the top 9.99% (752/7529) of the patients with the largest predicted risk to set the cutoff threshold for binary classification, the model gained an accuracy of 90.33% (6801/7529), a sensitivity of 56.6% (103/182), and a specificity of 91.17% (6698/7347).

CONCLUSIONS

Our model provided a more accurate prediction of severe COPD exacerbations in the next year compared with prior published models. After further improvement of its performance measures (eg, by adding features extracted from clinical notes), our model could be used in a decision support tool to guide the identification of patients with COPD and at high risk for care management to improve outcomes.

INTERNATIONAL REGISTERED REPORT

RR2-10.2196/13783
Additional Measurement Approaches for Sleep Disturbances. Comment on “A Transdiagnostic Self-management Web-Based App for Sleep Disturbance in Adolescents and Young Adults: Feasibility and Acceptability Study” (Preprint)
Authors: Tsai Wan-Tong , Liu Tzung-Liang
Published: January 2022

UNSTRUCTURED

N/A
Stillbirth and Neonatal mortality in Jordan: Findings from Jordan Stillbirths and Neonatal Deaths Surveillance System (Preprint)
Authors: Khader Yousef , Al-Sheyab Nihaya , Alyahya Mohammad , El-Khatib Ziad , Shattnawi Khulood , Abu Dalou Ahmad , Eyadat Taqwa , Alshorman Maria , Radaideh Tala , Batieha Anwar
Published: January 2022

BACKGROUND

Stillbirth and neonatal mortality declined significantly in high- and some middle- income countries because of the significant improvements in obstetric and neonatal care. Yet, stillbirth and neonatal mortality rates remain high in low-income countries. The main reason for low progress in reducing such stillbirths and neonatal deaths in Jordan is the scarcity of data on causes and contributing factors leading to these deaths.

OBJECTIVE

This study aimed to determine the rates, causes and risk factors of stillbirth and neonatal mortality in Jordan.

METHODS

An electronic stillbirth and neonatal deaths surveillance system was established in five large hospitals in Jordan. Data on all births, stillbirths and neonatal deaths and their causes during the period May 2019 – December 2020 were exported from the system and analyzed.

RESULTS

A total of 29,592 women gave birth to 31,106 babies during a period of 20 months in the selected hospitals. The stillbirth rate was 10.5 per 1,000 total births, the neonatal death rate was 14.2 per 1,000 live births, and the perinatal death rate was 21.4 per 1,000 total births. Of all neonatal deaths, 29.4% died within the first day of life and 77.8% died during the first week of life. For neonatal deaths occurred pre-discharge, the leading causes of death were respiratory and cardiovascular disorders (35.0%), low birth weight and prematurity (32.7%), and congenital malformations, deformations and chromosomal abnormalities (19.5%). Almost one third of stillbirths had unspecified cause of death (33.3% of antepartum stillbirths and 28.9% of intrapartum stillbirths). Acute antepartum event was responsible of 27.4% of antepartum stillbirths and acute intrapartum event was responsible for 13.2% of intrapartum stillbirths. Congenital malformations, deformations and chromosomal abnormalities contributed to 18.1% of antepartum stillbirths and 34.2% of intrapartum stillbirths.

CONCLUSIONS

There is a relative stability of stillbirth and neonatal mortality rates in Jordan. Several identified maternal and/or fetal conditions that contributed to stillbirths and/or neonatal deaths in Jordan are preventable. Focused care needs to be directed high-risk pregnant women and to neonates with low birthweight and respiratory problems.
Carotid Intima Media Thickness as a Predictor for the Severity of Coronary Artery Disease
Authors: Siregar Omar Mokhtar , Hasan Refli , Safri Zainal , Hasan Harris , Mukhtar Zulfikri , Akbar Nizam F.
Published: January 2022

Background: Coronary artery disease is the chief cause of non infection cause of death in the developing country, carotid intima-media thickness evaluationare used for over three decade to asses atherosclerotic burden, this study aimed to seek correlation between carotid intima-media thickness with coronary artery disease severity.Methods: This was a cross-sectional study involving 63 patients diagnosed with stable angina pectoris in Haji Adam Malik General Hospital Medan from November 2018 to December 2018. Carotid Doppler USG and Angiography were performed for each patients. Chi-Square test will be performed to analyze correlation between internal carotid intima-media thickness with Gensini score.Results: From 63 subjects, 23 subjects (82.1%) with internal carotid intimamedia thickness ≥ 0.75mm have Gensini score ≥20 while patients with carotidintima-media thickness <0.75mm 8 (22.9%) have Gensini score ≥20 (p<0.001). Cut-off point 0.55 mm (Sensitivity: 93.5% and Specificity: 87.5%) was a marker for high Gensini score.Conclusion: Internal Carotid intima-media thickness with cut-off point 0.55 mm can be used to predict the severity of coronary artery disease measured by Gensini Score in stable coronary artery disease patients.