bluuebunny/crossref_metadata_2025 huggingface dataset:
Coumarin Derivatives as Anticancer Agents for Lung Cancer Therapy: A Review
Authors: Kumar Manvendra , Singla Ramit , Dandriyal Jyoti , Jaitak Vikas
Published: January 2018

Background:

The prevalence of lung cancer is 14% among the newly diagnosed cancer cases worldwide.
Currently, the number of drugs that are in clinical practice is having a high prevalence of side effect and
multidrug resistance. Researchers have made an attempt to expand a suitable anticancer drug that has no MDR
and side effect.

Objective:

Extensive exploration of Coumarin derivatives as a potent inhibitor of variety of proteins including
EGFR, tyrosine kinase, ERK1/2, PI3K, HSP 90, Bax, STAT proteins, NF-κB and telomerase which have been
associated with lung cancer.

Method:

The recent literature was surveyed utilizing the online resources and databases including scifinder,
pubchem, EMBL, scopus and google scholar.

Results:

Upon analyzing the structure-activity relationship, it was found that N-aryl carboxamide, phenyl substitution
at the C-3 position and 1,2,3- triazolyl, trihydroxystilbene, amino substitution at the C-4 position of the
coumarin nucleus were the most effective in targeting lung cancer.

Conclusion:

This review is a collaborative and extensive compilation of synthetic strategies, mechanism of
action, and the structure-activity relationship thereof for the management of lung carcinoma.
Astragalin Attenuates UVB Radiation-induced Actinic Keratosis Formation
Authors: Li Na , Zhang Kun , Mu Xin , Tian Qiong , Liu Wenli , Gao Tianyuan , Ma Xiaona , Zhang Jian
Published: January 2018

Background:

Actinic Keratosis (AK), is the most common precancerous skin lesion induced by the
excessive Ultraviolet B (UVB) and is a significant threat to the public health. UVB exposure causes oxidative
DNA damage and is considered to be a significant contributor to AK and subsequent development of skin cancer.
Besides, activation of p38 MAPK also plays a significant role in the development of AK.

Objective:

This study aimed at the development of a nature compound which can inhibit UVB-induced AK.

Method:

MTS Cell Proliferation Assay Kit was used to detect the toxicity of astragalin. HE-staining, Immunohistochemical,
Western blot and Enzyme Linked Immunosorbent Assay were applied to examine the clinicopathologic
feature of AK and the change of p38 MAPK signal pathway treated with astraglin under the condition
of UVB in vitro and in vivo.

Results：In our clinical findings revealed that p38 MAPK, phospho-MSK1, and γ -H2AX were significantly
highly expressed in human AK tissue than the normal healthy skin tissue. Moreover, in vitro studies showed that
UVB induced the phospho-MSK1 and γ-H2AX in a time- and dose-dependent manner in HaCaT cells. Further,
in vitro kinase assay demonstrated that astragalin could directly bind to p38 MAPK and suppress p38 MAPK
activity. Furthermore, astragalin exhibited no toxicity and suppressed the UVB-induced expression of phospho-
MSK1 and γ -H2AX by suppressing p38 MAPK activity in a time-dependent and dose-dependent manner in
HaCaT cells. The in vivo studies with animal UV model demonstrated that astragalin inhibited UVB-induced
expression of phospho-MSK1 and γ-H2AX in Babl/c mice.

Conclusion:

These results suggested that p38 MAPK is a direct valid molecular target of astragalin for the attenuation
of UVB-induced AK. Furthermore, astragalin could be a potential promising novel natural therapeutic
agent for the prevention and management of UVB-induced AK with high target specificity and low toxicity.
Pre-clinical Validation of Mito-targeted Nano-engineered Flavonoids Isolated From Selaginella bryopteris (Sanjeevani) As A Novel Cancer Prevention Strategy
Authors: Bhargava Arpit , Pathak Neelam , Seshadri Sriram , Bunkar Neha , Mishra Dinesh K. , Lohiya Nirmal K. , Mishra Pradyumna K.
Published: January 2018

Background:

Novel bioactive plant secondary metabolites, including flavonoids, offer a spectrum of
chemo-protective responses against a range of human tumor models. However, the clinical translation of these
promising anti-cancer agents has been hindered largely by their poor solubility, rapid metabolism, or a combination
of both, ultimately resulting in poor bioavailability upon oral administration.

Objective:

To circumvent the challenges associated with herbal drug development and for effective integration
into clinical setting, nano-engineering is one of the emerging pragmatic strategies which has promise to deliver
therapeutic concentrations of bio-actives upon oral administration.

Method:

We assessed the nano-encapsulated flavonoid-rich fraction isolated from a traditional Indian herb
Selaginella bryopteris (Sanjeevani) (NP.SB). Both in vitro and in vivo studies were performed to evidence the
epigenetic protection mechanisms of NP.SB through a mitochondrial-targeted pre-clinical validation strategy.

Results:

The mito-protective activity of NP.SB revealed a dose-dependent effect when tested in GC-1 spg
(mouse spermatogonial epithelial) and B/CMBA.Ov (mouse ovarian epithelial) following exposure to Nsuccinimidyl
N-methylcarbamate, a potential human carcinogen. Smaller size, rapid internalization, faster mobility
and site specific delivery conferred significant cancer protection in cultured cells. Notably, this encapsulated
flavonoid supplementation; prevented emergence of neoplastic daughter clones from senescent mother
phenotypes in pro-oxidant treated GC-1 spg and B/CMBA.Ov cells by selective abrogation of mitochondrial
oxidative stress-induced aberrant epigenetic modifications. In vivo studies using a diethylnitrosamine and 2-
acetylaminofluorene mouse model demonstrated that NP.SB has a significant inhibitory effect on tumor growth
which clearly substantiated our in vitro findings.

Conclusion:

Anti-carcinogenic property in conjunction with low toxicity of NP.SB, underscores the translational
significance of dietary flavonoids as cancer-protective agents for preferential application in clinical
settings.
Development of a Nasal Donepezil-loaded Microemulsion for the Treatment of Alzheimer’s Disease: in vitro and ex vivo Characterization
Authors: Espinoza Lupe C. , Vacacela Marisol , Clares Beatriz , Garcia Maria Luisa , Fabrega Maria-Jose , Calpena Ana C.
Published: January 2018

Background:

Donepezil (DPZ) is widely prescribed as a specific and reversible acetylcholinesterase
inhibitor for the symptomatic treatment of mild to moderate Alzheimer's disease (AD).

Objective:

Considering the therapeutic potential of DPZ and the advantages offered by the intranasal
route as an alternative for drug administration, the aim of this study was the development and characterization
of a DPZ microemulsion (ME) for nose-to-brain delivery.

Method:

The ME was developed by construction of pseudoternary phase diagrams and characterized
by dynamic light scattering and transmission electron microscopy. Flow properties and viscosity, as
well as optical stability and stability under storage at different temperatures were evaluated. Finally, in
vitro release and ex vivo permeation studies through porcine nasal mucosa were accomplished.

Results:

A transparent and homogeneous DPZ-ME (12.5 mg/ml) was obtained. The pH and viscosity
were 6.38 and 44.69 mPa·s, respectively, indicating nasal irritation prevention and low viscosity. The
mean droplet size was 58.9±3.2 nm with a polydispersity index of 0.19±0.04. The morphological
analysis revealed the spherical shape of droplets, as well as their smooth and regular surface. Optical
stability evidenced no destabilization processes. DPZ release profile indicated that the ME followed a
hyperbolic kinetic model while the ex vivo permeation profile showed that the highest permeation occurred
during initial 4 h and the maximum permeated amount was approximately 2000 µg, which corresponds
to 80% of the starting amount of drug.

Conclusion:

We conclude that our nasal ME could be considered as a new potential tool for further
investigation in the AD.
Relationship Between Periodontal Disease and Serum Factors in Patients Undergoing Hemodialysis
Authors: Naghsh Narges , Sabet Negar Kanuni , Vahidi Forozan , Mogharehabed Ahmad , Yaghini Jaber
Published: January 2018

Background:

Chronic renal disease is a common condition with several recognized risk factors. Periodontal disease is a recently suggested risk factor for renal disease. We aimed to assess the relationship between periodontal disease and several serum factors in patients undergoing hemodialysis.

Methods:

This descriptive cross-sectional study was conducted on 57 patients undergoing hemodialysis. Periodontal examination was done by measuring the mean Pocket Depth (PD), Silness-Löe Plaque Index (PI), Ainamo and Bay Bleeding On Probing (BOP), Löe and Silness Gingival Index (GI) and Clinical Attachment Loss (CAL). Serum levels of albumin, calcium, phosphorus, hemoglobin, ferritin and creatinine were measuredviaa routine blood test. Cystatin C was separately measured. Data were analyzed using independent t-test, Pearson’s correlation coefficient, chi square test and Mann Whitney test (alpha=0.05).

Results:

37 men and 20 women were evaluated. Of these, 26.3% had periodontitis and 73.7% had gingivitis. Serum level of albumin (P=0.02) and ferritin (P=0.043) in patients with periodontitis was significantly higher than that in patients with gingivitis. The serum level of creatinine (P=0.02), cystatin C (P=0.013), calcium (P=0.046) and phosphorus (P=0.037) had a significant correlation with severity of periodontitis and increase in CAL.

Conclusion:

Increase in the serum levels of albumin and ferritin was related to the progression of gingivitis to periodontitis. Also, the serum levels of creatinine, cystatin C, calcium and phosphorus increased with an increase in CAL.
Identification of Bacteria in the Sputum of a Cystic Fibrosis patient; A Comparison of Phenotypic and Molecular Methods
Authors: Alfaresi Mubarak , Mahboub Bassam
Published: January 2018

Background:

Cystic fibrosis (CF), caused by mutations in the CF transmembrane conductance regulator gene, is a common autosomal recessive disease. Accurate isolation and identification of the bacteria underlying these infections are is critical to the therapeutic management of CF.

Objective:

To compare phenotypic bacterial identification with a molecular method in a CF patient sputum.

Methods:

Bacterial identification done by standard microbiological method from a CF patient. Same sample underwent a molecular method involving 16S rDNA amplification, cloning, and sequencing.

Results:

All isolated bacteria from culture were also found after cloning PCR Product. Conversely, 9 pathogenic bacterial species were only detected after PCR and cloning.

Conclusion:

This study supports prior suggestions that a sequence-based molecular approach to clinical microbiology can significantly enhance the standard clinical culture-based view.
Changing to Concept-Based Curricula: The Process for Nurse Educators
Authors: Baron Kristy A.
Published: January 2018

Background:

The complexity of health care today requires nursing graduates to use effective thinking skills. Many nursing programs are revising curricula to include concept-based learning that encourages problem-solving, effective thinking, and the ability to transfer knowledge to a variety of situations—requiring nurse educators to modify their teaching styles and methods to promote student-centered learning. Changing from teacher-centered learning to student-centered learning requires a major shift in thinking and application.

Objective:

The focus of this qualitative study was to understand the process of changing to concept-based curricula for nurse educators who previously taught in traditional curriculum designs.

Methods:

The sample included eight educators from two institutions in one Western state using a grounded theory design.

Results:

The themes that emerged from participants’ experiences consisted of the overarching concept,support for change,and central concept,finding meaningin the change. Finding meaning is supported by three main themes: preparing for the change, teaching in a concept-based curriculum, and understanding the teaching-learning process.

Conclusion:

Changing to a concept-based curriculum required a major shift in thinking and application. Through support, educators discovered meaning to make the change by constructing authentic learning opportunities that mirrored practice, refining the change process, and reinforcing benefits of teaching.
Assessment of the Peak Response of a 5MW HAWT Under Combined Wind and Seismic Induced Loads
Authors: Avossa Alberto Maria , Demartino Cristoforo , Ricciardelli Francesco
Published: January 2018

Background and Objective:

The rapid growth of the wind energy industry has brought the construction of large-scale wind turbines with the aim of increasing their performance and profits to areas characterized by high seismic hazard. Previous research demonstrated the seismic vulnerability of large-scale wind turbines when seismic and wind actions are considered simultaneously in the demand model. In this study, the response of the supporting structure of a land-based horizontal axis wind turbine under the combined effects induced by wind and earthquake is presented.

Method:

Using a decoupled approach, numerical simulations of the wind and seismic loads effects are performed separately using a specific model for the aerodynamic damping and then joined. Both simulations are done using free open-source software that are FAST simulating the aerodynamic response of the rotor and OpenSees simulating the dynamic behaviour of the tower. The fitted generalized extreme value distributions of the multi-hazard peak response in terms of base moment and shear, total drift, and top rotation are calculated for different seismic and wind load intensities by means of Monte Carlo simulations. The analyses are referred to the specific case study of a land-based wind generator.

Results and Conclusion:

The maximum demand is associated with the operational rated scenario and for high values of the peak ground acceleration, only the parked condition leads to larger values of the response if compared to others. The analyses showed that it is essential to consider the combined seismic and wind actions in the demand model to derive a complete multi-risk analysis of the land-based structures.
Estimation of Delay Times in Coupling Between Autonomic Regulatory Loops of Human Heart Rate and Blood Flow Using Phase Dynamics Analysis
Authors: Khorev Vladimir S , Karavaev Anatoly S , Lapsheva Elena E , Galushko Tatyana A , Prokhorov Mikhail D , Kiselev Anton R
Published: January 2018

Objective:

We assessed the delay times in the interaction between the autonomic regulatory loop of Heart Rate Variability (HRV) and autonomic regulatory loop of photoplethysmographic waveform variability (PPGV), showing low-frequency oscillations.

Material and Methods:

In eight healthy subjects aged 25–30 years (3 male, 5 female), we studied at rest (in a supine position) the simultaneously recorded two-hour signals of RR intervals (RRIs) chain and finger photoplethysmogram (PPG). To extract the low-frequency components of RRIs and PPG signal, associated with the low-frequency oscillations in HRV and PPGV with a frequency of about 0.1 Hz, we filtered RRIs and PPG with a bandpass 0.05-0.15 Hz filter. We used a method for the detection of coupling between oscillatory systems, based on the construction of predictive models of instantaneous phase dynamics, for the estimation of delay times in the interaction between the studied regulatory loops.

Results:

Averaged value of delay time in coupling from the regulatory loop of HRV to the loop of PPGV was 0.9±0.4 seconds (mean ± standard error of the means) and averaged value of delay time in coupling from PPGV to HRV was 4.1±1.1 seconds.

Conclusion:

Analysis of two-hour experimental time series of healthy subjects revealed the presence of delay times in the interaction between regulatory loops of HRV and PPGV. Estimated delay time in coupling regulatory loops from HRV to PPGV was about one second or even less, while the delay time in coupling from PPGV to HRV was about several seconds. The difference in delay times is explained by the fact that PPGV to HRV response is mediated through the autonomic nervous system (baroreflex), while the HRV to PPGV response is mediated mechanically via cardiac output.
Mapping Digital Fluency in Diverse Socio-Economic Status of Citizens of DKI Jakarta 2017
Authors: Parahita Gilang Desti
Published: January 2018

The loss of Ahok-Djarot, incumbent candidate pair, in the second round of gubernatorialelection was allegedly related to the spread of digital disinformation. In addition, racialand religious sentiments in the society of DKI Jakarta have been fathomed evident inthe last election. The phenomenon has driven a study on digital fluency in diverse socioeconomicstatus (SES) for example age, gender, religion, ethicity, religiousity, level ofeducation and level of income in family. Survey was conducted to 189 voters of DKIJakarta. Results show that respondents from different socioeconomic background havediverse digital fluency with the widest gaps occurred between people from lowest andhighest level of religiosity, income and education. Respondents from different gender,age generation and religion background do not have considerable fluency gaps. However,using pearson correlational analysis, only level of income and education that predictsdigital fluency level.Fenomena kekalahan Ahok-Djarot pada putaran kedua Pilgub DKI Jakarta tersebutditengarai mudahnya warga termakan informasi digital bohong. Selain itu, sentimenras dan agama di masyarakat DKI Jakarta yang selama ini bagaikan api dalamsekam dianggap terbukti pada Pilgub DKI terakhir. Fenomena tersebut mendorongdilakukannya riset mengenai tingkat kefasihan digital pada beragam status sosialekonomi. Status sosial ekonomi yang dimaksud dalam konteks riset ini adalah ialahusia, gender, agama, etnis, tingkat kesalehan beragama, tingkat pendidikan, dantingkat pendapatan dalam keluarga. Survei diselenggarakan terhadap 189 pemilih diDKI Jakarta. Temuan menunjukkan bahwa responden yang berlatar belakang beragamsosio ekonomi memiliki keragaman kefasihan digital pula dengan kesenjangankefasihan tertinggi terjadi di antara kelompok responden berkelas tertinggi danterendah di tingkat kesalehan, pendapatan dan pendidikan. Responden dari gender,generasi usia dan agama yang berbeda tidak menunjukkan kesenjangan fluensi yangpatut dipertimbangkan. Selain itu, dengan menggunakan analisis korelasional, hanyalevel pendapatan dan pendidikan yang mempengaruhi level kefasihan digital
Evaluasi buku teks pelajaran bahasa jepang tingkat dasar “Minna No Nihongo”
Authors: Wahyuningtias Hani
Published: January 2018

Tujuan dari penelitian ini adalah untuk menentukan dan memperoleh pemahaman tentang kualitas buku teks Jepang “Minna no Nihongo”. Metode yang digunakan dalam penelitian ini adalah metode evaluasi dengan teknik analisis isi. Model evaluasi yang digunakan adalah Evaluasi Berbasis Tujuan (Goal Based Evaluation) untuk mengukur dan menilai kualitas buku teks pelajaran bahasa Jepang. Dalam penelitian ini, dasar teoretis dari buku pelajaran yang dijelaskan oleh para ahli dieksplorasi dan dikembangkan oleh peneliti dalam bentuk konstruk instrumen untuk mengevaluasi buku teks bahasa asing. Instrumen ini terdiri dari empat komponen, yaitu: materi/isi, keterampilan berbahasa, penyajian, dan keterbacaan. Instrumen ini telah divalidasi oleh pakar perbukuan dan pakar bahasa Jepang, serta diujikan pada empat buku teks pelajaran seri “Minna no Nihongo” yang digunakan di Fakultas Sastra Jurusan Jepang Universitas Darma Persada. Berdasarkan hasil evaluasi, diketahui bahwa kualitas empat buku ditinjau dari empat komponen sekaligus dianggap baik. Namun, buku keterampilan membaca dan menulis ditinjau dari segi penyajian dianggap kurang baik. Instrumen ini diharapkan menjadi pelopor dalam mengevaluasi buku teks pelajaran bahasa asing yang digunakan di Indonesia.Kata kunci: evaluasi, buku teks pelajaran bahasa asing, instrumen penilaian buku teks pelajaran bahasa asing  THE EVALUATION OF JAPANESE TEXTBOOK BASIC LEVEL “MINNA NO NIHONGO ”AbstractThe purpose of this study is to determine and gain an understanding of the quality of Japanese textbooks “Minna no Nihongo”. The method applied in this study is the evaluation method with content analysis techniques. Evaluation model used is Goal Based Evaluation (Objective Oriented Evaluation) to measure and assess the quality of Japanese lesson textbook.In this study, the theoretical basic of the textbooks described by the experts is explored and developed by researcher in the form of instruments construct on evaluating foreign language textbook. This instrument consists of four components, namely: the material/content, language skills, presentation, and readability. This instrument has been validated by book expert and Japanese Language experts, as well as tested in four textbooks series “Minna no Nihongo” used in the Faculty of Literature Japanese Department in University of Darma Persada. Based on the results of the evaluation, it is determined that the quality of four textbooks observed in terms of four components all at once is clarified favorable. But reading and writing skills books observed in terms of presentation only are considered unfavorable. This instrument is expected to be a pioneer in evaluating foreign language text books used in Indonesia.Keywords: evaluation, foreign language textbooks, assessment instruments of foreign language textbooks
An evaluation model of islamic learning education program in madrasah aliyah
Authors: Anidi Anidi
Published: January 2018

The purpose of this study is: (1) to create the products as the evaluation model learning programs of Islamic education in madrasah aliyah, suitable, precise, and accurate, (2) to know how to test the suitability of the model to obtain the evaluation model of Islamic Education learning programs in madrasah aliyah which is valid, and reliable, and (3) determine the effectiveness of the application of evaluation model of Islamic learning programs that was developed. This  was a research and development method study (R & D), referring to the model of  Borg & Gall, the development process was simplified into three steps, namely: (1) the stage predevelopment  of models, (2) the stage of development of the model, and (3) the operational phase of the field (test model). The data were collected using questionnaires, interview, observation, documentation, and test. Data were analyzed using quantitative and qualitative. The conclusion of this research and development is: (1) evaluation model of Islamic Religious Education Learning program developed comprising: (a) the evaluation procedures, (b) the evaluation instrument, and (c) the evaluation guide. (2) according to the experts, PAI teachers, and principals, procedures, instruments, and evaluation guidelines  developed  are already good, and can be used, d) the instrument developed is entirely valid (load factor > 0.3), reliable (CR > 0.7), and qualified as a fit model (RMSEA ≤ 0.08 and NFI, CFI and GFI > .90). second, the expert's opinion, PAI teachers and principals, the developed evaluation model (EPH model) is declared effective,  practical, and easy to use, and supported by a valid and reliable instrument.
The evaluation of authentic assessment implementation of Curriculum 2013 in Elementary School
Authors: Wangid Muhammad Nur , Mustadi Ali , Senen Anwar , Herianingtyas Nur Luthfi Rizqa
Published: January 2018

This research was aimed to evaluate the implementation of authentic assessment of elementary school in Province of Yogyakarta and also to know the obstacles of its implementation. This was an evaluative research by a Stake's evaluation model approach. The results of observation in compare to the standard of assessment should be criteria to determine the succeed. This research subjects were elementary teachers in Province of Yogyakarta. Observation, interview, and documentation were used to gather data. The research showed that: (1) Planning (antecedents) stage or understanding towards authentic assessment planning has not been fulfilled the standard to be categorized as Good with percentage of 68.75%; (2) Process (transaction) or implementation stage that obtained 63.41% in percentage was classified in Good category; (3) Outcome stage or authentic assessment report showed 68.48% in percentage and should be categorized Good. The implementation of authentic assessment in Province of Yogyakarta elementary schools have not 100% met the standard. Therefore, results from this research finding were expected to be tools to improve performance from all stakeholders.
Pengembangan tes keterampilan dasar olahraga bola tangan bagi mahasiswa
Authors: Susanto Ermawan
Published: January 2018

Artikel ini bertujuan untuk: (1) menyusun butir-butir tes keterampilan dasar olahraga bola tangan, dan (2) mengetahui validitas dan mengestimasi reliabilitas tes keterampilan dasar olahraga bola tangan. Metode penelitian yang digunakan adalah research and development. Subjek penelitian 30 mahasiswa. Instrumen pengumpulan data berupa lembar observasi dan kuesioner. Jumlah judge yang terlibat 3 orang. Validitas diketahui dengan validitas isi dan reliabilitas instrumen menggunakan korelasi Inter Rater. Hasil penghitungan koefisien korelasi, diketahui bahwa skor rater 1 = 0,999, skor rater 2 = 0,996, dan skor rater 3 = 0,991. Hasil penghitungan reliabilitas diestimasi dengan Koefisien Alpha sebesar rxx = 0,994. Hasil pengembangan tes keterampilan dasar olahraga bola tangan bagi mahasiswa menghasilkan 3 (tiga) jenis tes yaitu: (1) Tes keterampilan passing dengan sasaran ke tembok ( waktu: 30 detik), (2) Tes keterampilan dribbling (waktu: 30 detik), (3) Tes keterampilan flying shoot melakukan 3 kali tembakan dari tiga posisi: kiri, tengah, dan kanan.Kata kunci: pengembangan tes, keterampilan dasar, bola tangan DEVELOPMENT OF HANDBALL BASIC SKILLS TEST FOR STUDENTSAbstractThis article aims to: (1) develop a grain handball basic skills test, and (2) determine the validity and reliability of estimating handball basic skills test. The method used is research and development. Subject of the study 30 students. Data collection such as observation sheets and questionnaires. Number judge involved three people. Validity determined by content validity and reliability of the instrument using the correlation Inter Rater. The results of the correlation coefficient calculation, it is known that the rater score 1 = 0.999, the rater score 2 = 0.996, and the score rater 3 = 0.991. The results estimated by the reliability calculation of Alpha Coefficient rxx =0,994. The result of the development of the form of handball basic skills test for students produce three (3) types of test are: (1) The test of passing skills the target wall (time: 30 seconds), (2) the tests of dribbling skills (time: 30 seconds) (3) The tests of flying shoot skills from three positions: left, center, and right.Keywords: test, development, handball basic skill
Design Guidelines of Residential Environments to Stimulate Children's Creativity
Authors: Faizi Mohsen , Azari Amirreza Karimi , Maleki Saeid Norouzian
Published: January 2018

Because of age growth, activation, promotion of creativity in children is extremely valuable. In order to improving creativity, there are some methods to encourage children's mind to new thinking and develop the creativity. One of these methods is the impact of natural or artificial environment to increase children's creativity. Because children spend a lot of their time with family at home, physical environment of house, effects on the children talent development and creativity. In the present study, based on combining analysis of the survey, we proposed some design principles of residential spaces to enhance children's creativity.
Explanatory Models of Perception of Safety in a Public Housing Estate, Lagos, Nigeria
Authors: Okunola Segun , Amole Dolapo
Published: January 2018

This paper reports a study on the perception of safety in a public housing scheme. It uses two different models to explain this phenomenon. The rationale was that the components of these models are associated with the quality of life of residents. The results suggest that the model which explains the perception of safety using facilitating factors (vulnerability and disorder) is more explanatory than the model which uses inhibiting factors (social participation and sense of community).
Factors Influencing Customers Willingness to Pay for Halal Logistics
Authors: Kamaruddin Rohana , Iberahim Hadijah , Shabudin Alwi
Published: January 2018

The demand towards an effective and acceptable halal logistics services is timely to meet the requirement of international trade of halal products. The objective of the study is to explore the underlying determinants that are likely to influence the customer willingness to pay (WTP) for halal logistics. The study uses logit model to determine the extent of factors' influence on the respondents' willingness to pay. Findings of the study reveal that respondents are willing to pay for halal logistics, due to the demand and cost towards halal logistics services. Result of this study facilitates the establishment of an efficient and realistic halal logistics policy requirement in Malaysia.
Gender's Perception: Does the rain noise generated underneath metal deck roof system affects occupants comfort?
Authors: Md Idris Muhammad Fahmi , Ayop Seti Mariam
Published: January 2018

Occupants' perception towards the value of indoor environment has always been a crucial issue. Having a good quality in an indoor environment influences the way occupants' behave in their daily activities. Moreover, there are differences on the gender perspective on how they perceive the value of indoor environment. However, gender perception towards rain noise effects in relation to students' activities has been overlooked until today. From the findings it can convey beneficial information regarding the quality of life towards students' living. Conclusively, the overall finding reveals those female students are more annoyed compared to the opposite gender.
Investigating Cross-Cultural Differences in Personal Space: Kurdish and Northern women in Iran
Authors: Mohammad Niay Gharaei Fatemeh , Rafieian Mojtaba
Published: January 2018

This study investigated cross-cultural differences in regard to the size of personal space among two Iranian sub-cultures (Kurdish and Northern women) vis-à-vis strangers. Methodology of research designed on participant observation, stop-distance method and questionnaire. A random size of 100 Kurdish and Northern women was selected in Sanandaj and Sari cities. Moreover, to examine the survey Chi-Square Test and Independent Sample Test were conducted. The results show that Kurdish women require more inter-personal space while walking and sitting than Northern (Mazani) women do. These findings assist environmental designers to represent strategies for achieving privacy in relation to Iranian sub-cultures.
Methodological Approach to Assessing Child Centricity in Urban Schools of India
Authors: Khan Smita , Kotharkar Rajashree
Published: January 2018

Environment-behaviour studies have proved the power of the environmental container to impact inhabitants in a significant way. This paper is part of an on-going doctoral research on evaluating building performance of urban Indian schools using Post Occupancy Evaluation as a major tool through its primary users- the students. An appropriate methodology was evolved in response to the outcomes of a pilot survey that identified unique ground situation. It assisted in understanding the status of urban learning environs from point of view of child centricity & in conclusion enabled the research enquiry to recommend parameters for a student-friendly & inclusive school design.
Multiculturality in the Indonesia's Biofuel Innovation Initiative: Critical issues of land use and sustainable environment
Authors: Nurlaila Ida , Yuliar Sonny
Published: January 2018

The Presidential decree was triggered national-scale energy plant cultivation to all districts. It is based on the assumption that Indonesia's energy security problem need to be addressed for accommodating poverty and environment problems. Until today the main objective of the program has not materialized, social conflicts that emerged mostly triggered by land usage and environment issues. While energy-economic calculation is central in the biofuel program conception, the evidences reveal a wide range of cultural issues taking a significant position in the program adoption at rural communities. In other words, multiculturality is a critical issue in the biofuel program adoption.
Predictors of Prolonged Hospital Stay in Cardiac Surgery
Authors: Khairudin Zuraida
Published: January 2018

The prolonged stay after cardiac surgery can significantly decrease the quality of life. Many studies have assessed the risk factors associated with length of stay but only a few have discussed the risk factors of prolonged stay after surgery. Therefore, this study is aimed to determine the risk factors affecting long term stay in hospital after CABG and to make comparison between group for each risk factors. All the risk factors were determined by Kaplan-Meier analysis. Overall, 3096 of CABG patients were discharged within less than 14 days, whereas 332 patients required prolonged (>14days) stays. The findings from the suruiual analysis indicated that patients with diabetes and wound infection stayed longer in the hospital.
Sustainable Tourism Design through Preserving Regional Identity: A Study from Iran
Authors: Mokhtarshahi Sani Rafooneh , Mahasti Payam
Published: January 2018

Recent efforts dedicated to the further development of tourism have significantly increased awareness and boasted the economic growth of Iran. Accordingly, Eslami Island project aimed at advancing the regional and national tourism. Regional identity was the key factor in the design process for Eslami island tourism developments, meeting its obligation as a sustainable system. This article explores the importance of 'regional identity', and its' use to regenerates the project, thus portraying other principles of sustainable tourism.
Light and Electron Microscopic Study of Lungs in Bidri Goat and Deccani Sheep
Authors: Ashwini S. , Pawar A. Ashok , Sathisha K. KB. , Girish M. H.
Published: January 2018

The histological study of lungs in Bidri goat (Capra hircus) and Deccani sheep (Ovis aries) was
carried out to know the structural differences in lungs of these animals. Lungs of both the species
had respiratory bronchioles, alveolar duct, alveolar sac and alveoli. Respiratory bronchioles were
lined by simple cuboidal epithelium in both the species and more number of respiratory bronchioles
was seen in adult Bidri goat than adult Deccani sheep. The alveolar ducts were lined by low cuboidal
to simple squamous epithelial cells. Alveoli were spherical structures lined by flat and membranous
Type-I pneumocytes and large dome shaped Type-II pneumocytes. In transmission electron
microscopy (TEM), more numbers of lamellar bodies were seen in cytoplasm of Type-II pneumocytes
of Deccani sheep as compared to Bidri goat. Macrophages and mast cells were noticed in
interalveolar septa of both the species. In scanning electron microscopy (SEM), no major structural
difference was noticed.
Alterations in Ruminal Fluid and Serum Biochemical Constituents in Goats Affected with Ruminal Acidosis
Authors: Chavelikar P. R. , Mandali G. and Neha Rao C. , Rao Neha
Published: January 2018

Ruminal acidosis is an important clinical emergency in small ruminants. In this study, eight healthy
farm goats and 24 goats presented at TVCC of the college of Veterinary Sciences and A.H., Anand
with clinical signs of ruminal acidosis and having rumen liquor pH below 6 were examined for
alterations in the ruminal fluid and serum biochemical parameters. Among various rumen fluid
parameters evaluated, the mean values of rumen fluid pH decreased significantly (4.71±0.11 vs.
6.90±0.10), while sediment activity time (46.67±1.20 vs. 24.50±0.78 min) and methylene blue
reduction time (29.50±0.73 vs. 10.03±0.27 min) increased significantly in acidotic goats. The normal
greenish, aromatic viscous color, odour and consistency of rumen fluid of healthy goats also
changed to milky grey/creamy, sour/pungent watery in acidotic goats. The rumen protozoal activity
decreased to nil in acidotic goats as compared to the healthy goats. Among various serum
biochemical constituents, the mean values of glucose (92.43±1.37 vs. 74.13±1.83 mg/dl), BUN
(26.49±0.47 vs. 22.63±1.19 mg/dl), serum creatinine (01.01±0.02 vs. 00.83±0.02 mg/dl) and
albumin (03.22±0.03 vs. 03.05±0.05 g/dl), ALT (56.75±1.55 vs. 27.88±1.14 IU/L) and AST
(93.25±1.82 vs. 54.00±1.75 IU/L), increased significantly, while there was significant decrease in
serum calcium (09.09±0.14 vs. 10.29±0.08 mg/dl) in acidotic goats. The mean values of alkaline
phosphatase (IU/L) in acidotic goats increased non-significantly from the base values of healthy goats.
Occurrence of Neglected Picobirna Virus in Buffalo Calves Associated with Diarrhoea
Authors: Prasad Minakshi , Brar Basanti , Ikbal Ikbal , Ranjan Koushlesh , Misri Jyoti
Published: January 2018

Picobirna viruses (PBVs) thought to be neglected viruses, are emerging as causative agents of viral gastrointestinal infections in human and other animal species with enteritis. In the present study, a total of 408 fecal samples of diarrheic buffalo calves of under age of 2 months were collected from different locations in Haryana. These samples were preliminarily screened for PBV by RNApolyacrylamide gel electrophoresis (RNA-PAGE). The RNA-PAGE positive samples were further confirmed by RT-PCR using RdRp gene specific primer pair PicoB25 (+) and PicoB43 (-) for amplification of genogroup I PBV that generated an amplicon of 201 bp. Out of 408 buffalo calves fecal samples, 52 (13%) samples were found positive for genogroup 1(GGI) PBV using RT-PCR. Genogroup II (GGII) specific primer generating 369 bp product size did not show amplification in any of the samples. The results suggested occurrence of PBV in Haryana State with predominance of GGI PBV. To the best of our knowledge, this is the first report of detection as well as occurrence of GGI picobirna virus among diarrheic buffalo calves in Haryana State.
Serum Progesterone, Oestradiol-17β, FSH and LH levels in Anestrus Surti buffaloes treated with Ovsynch alone and in combination with PRID
Authors: Savani H. R. , Khasatiya C. T. , Saxena Swati , Patel S. B. , Singh V. K.
Published: January 2018

This study was carried out on 18 postpartum anestrus Surti buffaloes, divided into three equal
groups (6 in each) to evaluate the serum progesterone, oestradiol-17β, FSH and LH concentrations
(by ELISA) before, during and after Ovsynch and Ovsynch + PRID protocols. Six anestrus buffaloes
each were treated with standard Ovsynch protocol (T1) and Ovsynch along with PRID (Progesterone
releasing intravaginal device) protocol (T2) with fixed-time AI (FTAI). Six anestrus buffaloes were
kept as untreated control (T3). Blood samples were obtained from the animals on day 0 (before
treatment), day 4 (during treatment), day 8 (after PGF2α injection), day of induced estrus/FTAI and
day 18 post-AI (after treatment). The mean serum progesterone level on day 4 was significantly
(p less than 0.01) higher in the T2 group as compared to T1 and T3 groups, while the level on day 8 was
significantly (p less than 0.01) higher in both the treatment groups (T1 and T2) as compared to control group,
however there was no significant difference (p>0.05) on the day of estrus between three groups.
The mean serum oestradiol-17β and follicle stimulating hormone (FSH) levels on 8th day were
significantly higher (p less than 0.01) in both the treatment groups (T1 and T2) as compared to control group
(T3). However, there was no significant difference on day 0, 4, day of estrus and day 18 post-AI
between groups. The mean serum luteinizing hormone (LH) levels of acyclic buffaloes were not
found significantly different (p>0.05) among days in any of the treatment and control groups. But
the mean LH concentration on the day of estrus in the T1, T2 and T3 was significantly higher (p less than 0.01)
and thereafter decreased markedly on 18th day post-AI in all the groups. The conception rates at
FTAI/first estrus in three groups were 66.66%, 50.00% and 75.00%, respectively.
Surgical Correction of Congenital Bilateral Patellar Luxation in a Pup - A Case Report
Authors: Arif Basha K. Mohd. , Murthy K.M. Srinivasa , Ranganath L.
Published: January 2018

Luxation of patella may be congenital or traumatic origin, and can affect any breed. The congenital
form is related to developmental abnormalities of the limb that create malalignment of quadriceps
group of muscles. With underlying abnormalities of hip and stifle joint congenital lateral patellar
luxation have skeletal abnormalities like retroversion of femoral head and neck, coxa vara (altered
angle of inclination), genu valgum and shallow trochlear groove with poorly developed trochlear
ridges (Denny and Butterworth, 2006). Luxation of patella is a common cause of lameness in dog
which can be in medial or lateral displacement. The incidence of medial patellar luxation is 5 times
more than lateral luxation and is seen more in large breeds of dogs. Lateral patellar luxation may
predispose the dogs to knock knee (genu valgum) and cow hock (hock valgus) condition (Robins,
1990). The cause of lateral patellar luxation is unknown but is thought to be related to anteversion
or coxa valga of the coxofemoral joint, which shifts the line of force produced by the pull of
quadriceps lateral to the longitudinal axis of the trochlear groove. This abnormally directed lateral
force pulls the patella from the trochlear sulcus causing skeletal abnormalities (Fossum, 2002).
Haematological Alterations in Cattle Infected with Trypanosoma evansi
Authors: Pandya S. S. , Hasnani J. J. , Hirani N. D. , Patel P. V.
Published: January 2018

This study was performed to unmask the haematological alterations in Trypanosoma evansi infected
cattle. Blood samples from 50 Trypanosoma infected and 50 non-infected from Anand and
Mahisagar districts were collected for the present study. Animals were bled from the jugular vein
into 10 ml vacutainers containing EDTA for the estimation of various haematological parameters.
The haematological parameters of cattle infected with T. evansi revealed decreased Hb, PCV, TEC,
MCV, MCH and blood glucose level also (40.67±1.71 vs. 70.76±1.73 mg/dl), and increased TLC
and MCHC than those of non-infected healthy cattle. The neutrophil and eosinophil counts were
significantly increased (P less than 0.01) from 37.06±0.95 to 41.44±1.03, 4.47±0.25 to 7.97±0.24 % indicating
eosinophilia and neutrophilia in infected cattle. Lymphocyte count was significantly (P less than 0.01) reduced
from 54.55±1.01 to 46.96±0.65 % indicating lymphocytopenia, while monocytes level increased non significantly
and basophils level increased significantly in infected cattle over healthy ones.
A sociologia do direito de Marx: interdependência entre a forma-jurídica e a forma-valor no capitalismo
Authors: Bastos Junior Ronaldo Carvalho
Published: January 2018

O objetivo deste trabalho é mostrar, a partir da obra econômica de Marx, a conexão existente entre o modo de produção capitalista (forma-valor) e o direito (forma-jurídica). A hipótese é que, para Marx, estas duas “formas” são indissociáveis no capitalismo e, portanto, não podem ser investigadas de modo apartado, pois a forma-jurídica legitima constantemente a forma-valor.
Sociologia do direito em versus à dogmática jurídica?
Authors: Da Silva Artur Stamford
Published: January 2018

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OCCUPATIONAL ASPIRATIONS OF ADOLESCENTS IN RELATION TO THEIR SELF CONCEPT
Authors: SUNAINA SUNAINA
Published: January 2018

Life is full of struggles and a person has to face many challenging situations where he/she needs to make right decisions. With the advancement of scientific knowledge and gradual development of materialistic outlook, it is believed that education should enable the individual to earn his living .Occupational aspirations in the formative years of life influence the vocational choice in the later life, which determine individual’s success in regard to job satisfaction, productivity and adjustment. So, it is imperative for the teachers to know their occupational aspirations, interest, self concept etc. A sample of 200 senior secondary school students was randomly drawn from govt. and private schools located in Ferozepur. Significant difference has been found in the level of occupational aspirations of adolescent boys and girls. Insignificant difference has been found in the level of self concept of adolescent boys and girls. Insignificant relationship has been found between occupational aspirations and self concept of adolescents.
ABSTRACT INTELLIGENCE OF GRADUATE STUDENTS IN RELATION TO THEIR RISK TAKING BEHAVIOUR
Authors: Arya Sunita , Kumar Parmod
Published: January 2018

The study was conducted to determine the relationship between abstract intelligence of graduate students in relation to their risk taking behaviour. The participants were 600 degree college students of Haryana state studying in different streams viz. Art, Science, Commerce, Pharmacy and Education. Cattell and Cattell Culture Fair (Free) intelligence Scale by Kapoor, Rao and Singh. {Scale III(CFIS-III)} for measuring abstract intelligence and Risk Taking Questionnaire (RTQ) by V.N.Sinha and P.N.Arora were used for the study. Mean, Standard Deviation and ‘z’ test were used for compare the values among different groups. The result of the study shows that the male students were significantly differ in abstract intelligence than the female students studying at graduate level while the male and female students studying in professional courses at graduate level does not differ in abstract intelligence whereas male male students were significantly differ in abstract intelligence than the female students studying in non professional courses at graduate level
Perception of under graduate students about Educational Environment (An Empirical Study of district Mathura UP)
Authors: Chahar Satyendra Singh
Published: January 2018

Educational environment and other educational institutes define the basic framework of education. Ministry of Science, higher education and Educational Organizations are some of the most important and widespread social organizations which hold the responsibility of selection and transmittance of values and custom to future generation. Educational Organization has direct influence not only on development of latent talents and increasing knowledge and abilities of students but also leads to an increase in national annual production and gross production of every country.
With a profound look, we understand that education plays a remarkable role in every society in training children and future generation who are all the assets of a country. The conclusion of the research is that under graduate students are un-aware to educational environment and their educational rights.