bluuebunny/crossref_metadata_2025 huggingface dataset:
PROGNOSTIC VALUE OF TUMOR STROMA RATIO IN TRIPLE NEGATIVE BREAST CANCER
Authors: Zakhartseva Liubov M. , Yanovytska Mariia A.
Published: April 2021

The aim: The purpose of this study is to investigate prognostic value of tumor stroma ratio in triple negative breast carcinomas.
Materials and methods: This cohort retrospective study included a total number of 232 previously untreated operational materials with primary stage I-III triple negative
breast cancer. The median follow-up period was 3.8 years for overall survival and 3.2 years for disease-free survival. Tumor stroma ratio was evaluated by two pathologists
(Kappa coefficient was 0.71 and 0.84, respectively).
Results: Kaplan-Meier curves with logrank test statistically significantly showed relationship between tumor stroma ratio and both overall and disease-free survival. The Cox
proportional hazards model showed tumor stroma ratio is a strong independent prognostic factor for triple negative breast carcinomas with hazard ratios of 2.11 (p=0.002) for
overall survival and 1.83 (p=0.004) for disease-free survival in multivariate analysis.
Conclusions: Triple negative breast tumors with high stroma ratio have worse overall and disease-free survival compared to low stroma ratio tumors. Investigation of tumor
stroma ratio doesn't require any additional costs and slide preparation. It can be added to routine breast cancer investigation to expand knowledge about cancer prognosis.
SUBSTANTIATION OF COMPONENTS OF AVAILABILITY AND INTEGRATION OF PRIMARY HEALTH CARE ASSOCIATED WITH AMBULATORY CARE SENSITIVE CONDITIONS IN UKRAINE
Authors: Lekhan Valery N. , Hrytsenko Liudmyla O.
Published: April 2021

The aim: Identifying the components of availability of Primary Health Care (PHC) and integration between PHC and secondary Health care (SHC) which need strengthening to reduce the rate of Ambulatory Care Sensitive Hospitalizations (ACSH) in Ukraine. Materials and methods: The study was conducted in two stages: the focus of interviewing experts on the list of components of the availability of PHC and its integration with SHC; survey of our questionnaire is based on the results of the first stage of the study. The responses of 93 respondents – 20 experts and 73 general practitioners/family doctors – were analyzed using descriptive and analytical statistics. Results: There were identified 14 components of PHC availability and 8 integration components of PHC with SHC, their quantitative value (in points) of impact on ACSH. The informativeness of components is confirmed by the agreement of opinions of experts on their list (concordance coefficient W = 0.75 -0.87; p <0.01) and the reliable correlations of scores of impact assessments of the identified components with overall values of the impact availability PHC and the integration between PHC and SHC on the ACSH. Conclusions: The results of the study can be used to develop an action plan for reform of PHC, the implementation of which will reduce rates hospitalizations of Ambulatory care sensitive conditions and increase the efficiency use of limited resources of health care system of Ukraine.
COMPARATIVE ANALYSIS OF INCIDENCE AND MORTALITY FROM GASTRIC CANCER AMONG THE POPULATION OF EUROPE AND UKRAINE
Authors: Domanchuk Tetiana I. , Chornenka Zhanetta A. , Hrytsiuk Mariana I.
Published: April 2021

The aim: To study the incidence and mortality from gastric cancer in Europe and Ukraine.
Materials and methods: Using statistical and medico-epidemiological methods, the analysis of the database of the National Cancer Registry of Gastric Cancer and Global
cancer statistics 2018.
Results: Gastric cancer remains an important cancer worldwide and is responsible for over 1,000,000 new cases in 2018 and an estimated 783,000 deaths, making it the fifth
most frequently diagnosed cancer and the third leading cause of cancer death. Among men, it is the most commonly diagnosed cancer and the leading cause of cancer death
in several countries of Europe, including Ukraine. Incidence rates are markedly elevated in Central/Eastern Europe, whereas the rates in Northern Europe are generally low. In the dynamics of the last decade, the primary incidence of gastric cancer has shown a tendency to decrease, as in Ukraine, from 25.5 per 100 thousand population in 2010 to 19.5 similar cases in 2019, which is -23.5% visibility) and in the Chernivtsi region (on -22.3% visibility). In Ukraine, as well as in Europe, the incidence and mortality of gastric cancer in men is 2 times higher than in women.
Conclusions: Incidence and mortality rates have declined in Europe in the past decades. Trends in the ten-year dynamics of reducing the incidence and mortality of gastric cancer in Ukraine prove the effectiveness and feasibility of introducing preventive measures at the state level in the future.
ANALYSIS OF STUDENTS' SOMATIC HEALTH AND EMOTIONAL STATE DURING SPORTS GAMES CLASSES
Authors: Shaposhnikova Iryna I. , Korsun Svitlana M. , Arefieva Larysa P. , Kostikova Olga V. , Serhiіenko Volodymyr M. , Korol Svitlana A. , Riabchenko Viktor G.
Published: April 2021

The aim: Is to investigate the impact of sports games (football) on the level of somatic health and emotional state of students in the process of studying.
Materials and methods: The study was conducted at Kharkiv State Academy of Physical Culture and Sumy State University (Ukraine) in 2018-2019. The study involved 87
male students of the main department. Two groups were formed: an experimental group (EG, n=42), the students of which were engaged in a sports-oriented form of physical education (in the class of football), and a control group (CG, n=45), the students of which were training according to the traditional methods of organizing physical education classes at higher education institutions. The somatic health of students was assessed according to the method of H. L. Apanasenko, which provided for the determination of body mass, life, power, and Robinson indexes, heart rate recovery time after a standard exercise. The emotional state of students was determined by the WAM (Well-being,
Activity, Mood) methodology.
Results: At the end of the study, the EG students showed a significantly better level of somatic health than the CG students; the difference was significant and accounted for
3.18 points (p<0.001). At the same time, during the study, the EG students had a more pronounced significant increase in all studied health indicators (p<0.001). The best
emotional state level of the students of both groups was recorded at the end of the study, but in the EG students it was significantly (p<0.05) better than in the CG students by 0.55-0.73 points.
Conclusions: It was found that sports games classes, including football, had a positive effect on the level of somatic health and emotional state of students. Significant changes were observed in the performance of the respiratory and cardiovascular systems of students. The high level of somatic health and good emotional state of students will help to improve mastering academic disciplines at higher education institutions, provide preparation for active life and help to improve future professional activities.
MODERN EPIDEMIOLOGICAL ASPECTS OF THE PROBLEM OF UROGENITAL MYCOPLASMIS AMONG THE FEMALE POPULATION OF UKRAINE
Authors: Haliienko Liudmyla I. , Zamkevych Viktoriia B. , Zholobko Oleksandr V. , Mykytenko Nataliia M. , Velikaia Nataliia V.
Published: April 2021

The aim: To study and analyze the dynamics, age, and regional characteristics of the incidence of urogenital mycoplasmosis in Ukraine during 2014-2019 and to substantiatemedical and organizational approaches to improving the prevention of urogenital mycoplasmosis among women.
Materials and methods: To study the dynamics, age, and regional characteristics of the prevalence and incidence of urogenital mycoplasmosis in women, reference and statistical materials of the State Statistics Service of Ukraine, reference materials and data from reporting forms No. 9, 34, 35 of the Center for Medical Statistics for 2014-2019 were used.
Results: The current trends in the dynamics of the incidence of urogenital mycoplasmosis among female population in Ukraine during 2015-2019 are determined, its age features are established, the regional distribution of administrative territories of Ukraine according to the incidence of urogenital mycoplasmosis is substantiated, medical and organizational approaches to improving menopause among women are substantiated.
Conclusions: The results of the study showed that although urogenital mycoplasmosis is most often diagnosed among women of childbearing age, the risk of infection exists
for women of all ages, which indicates the urgency of providing effective measures to prevent it.A wide range of regional indicators of incidence of urogenital mycoplasmosis
in women was established: from 0.9 per 100 thousand female population in the Zakarpattia region to 230.9 per 100 thousand in Kharkiv region, with in excess of the average Ukrainian indicator in a number of oblasts by1.8-3.2 times. There is a tendency towards redistribution during 2010-2018 of the age structure of patients with urogenital mycoplasmosis: against the background of a slight decrease in the proportion of age groups from 0 to 14, 15-19, 20-29 years there is an increase in the proportion of other age groups, but the first rank place, as in previous years, is retained by the age group of 20-29 years: 48.4% in 2010, 39.1% in 2018). A statistically reliable correlation connection between age and the level of incidence of urogenital mycoplasmosis among women is not revealed.
INTERACTION LINKS OF HEALTHCARE INSTITUTIONS WITHIN ONE HOSPITAL DISTRICT
Authors: Stovban Mykola P. , Mykhalchuk Vasyl M. , Tolstanov Alexander K. , Maglona Vira V.
Published: April 2021

The aim: Theoretical substantiation and determination of the main characteristics of the interaction links of medical institutions within one hospital district in the conditions
of aggravation of the epidemiological situation in Ukraine on the analysis basis of the legislative base and elaboration of literary sources.
Materials and methods: In the work is used a range of methods: content analysis, bibliosemantic, systematic approach, analysis of products of activity.
Conclusions: The authors propose a doctrinal definition of the term “hospital district”. The key problems of the domestic healthcare sector in the context of a pandemic have also
been identified. The author points out that in order to successfully reform the health care system and the effective interaction of hospitals in one hospital district, it is necessary
to pay attention to funding sources and proper legal regulation, as without the latter any initiatives will have no legal force and will be ignored. health care may be ineffective.
POURQUOI MANAGEMENT & DATA SCIENCE ABANDONNE L’ÉVALUATION EN DOUBLE AVEUGLE ?
Authors: CLAUZEL AMÉLIE , MAMAVI Olivier , RICHÉ CAROLINE , ZERBIB ROMAIN
Published: April 2021

La globalisation du secteur académique, conjuguée à une accélération sans précédent de la transformation digitale, implique de repenser en profondeur le rôle des revues scientifiques (Mamavi et Zerbib, 2020). C’est en tout cas la conviction de Management & Data Science, une plateforme ouverte de création et de diffusion de la connaissance sur le thème de la transformation digitale. Management & Data Science offre une alternative concrète à la logique du “publish or perish” (Mamavi et Zerbib, 2019) en permettant une reconnaissance de nos auteurs via les altmetrics. La ligne éditoriale de notre revue défend un positionnement fondé sur la rigueur, la pertinence, la vitesse et l'impact alternatif. Management & Data Science estime qu'une étude peut être qualifiée de scientifique dès lors qu'elle répond à au moins deux critères fondamentaux : la transparence et la reproductibilité. Or, le double aveugle ne nous semble pas ici constituer un moyen incontournable pour évaluer ces deux critères.
Need to Broad-Base Higher Education
Authors: Imran Majeed Syed Muhammad , Ahsan Gilani Rehma
Published: April 2021

Establishment of human intellect and expertise necessitates wide scope of knowledge and understanding. Post qualification, many practical jobs wherein the required expertise includes social understanding and abilities which are not included in STEM subjects. Organization needs civic sense, team work, understanding, compassion and good communication. In reality, the market needs that the product of higher education being employed has these abilities so as to be able to get well within the organizational work forces.

A well-developed human package is hardly complete without appropriate knowledge and insight of, for example, philosophy, anthropology, economics, law, psychology, belief system/religions, geography , history and politics, amongst others. Without these, the very purpose of one's role within an organization, and the society at large, remains very incomplete.

Obtaining passing marks in merely a few science specific subjects as usually defined in narrowly defined curricular stop way short of meeting the market demands. Inclusion of some knowledge of social sciences, humanities and arts would help create higher educated people with better understanding of the human condition and the society. Better understanding is the essential prerequisite for being comfortable with oneself and one's society.

 

On the same account, integrative education and research needs to be put in place to bridge knowledge, modes of inquiring and pedagogies from multiple disciplines, within every higher education program.
Caristi type fixed point theorems using Száz principle in quasi-metric spaces
Authors: AAMRI M. , CHAIRA K. , LAZAIZ S. , MARHRANI EL-M. ,   LABORATORY OF ALGEBRA ANALYSIS AND APPLICATIONS (L3A) HASSAN II UNIVERSITY OF CASABLANCA FACULTY OF SCIENCES BEN M’SIK AVENUE DRISS EL HARTI, B. P 7955, SIDI OTHMANE, CASABLANCA, MOROCCO,   LABORATORY OF ALGEBRA ANALYSIS AND APPLICATIONS (L3A) HASSAN II UNIVERSITY OF CASABLANCA FACULTY OF SCIENCES BEN M’SIK AVENUE DRISS EL HARTI, B. P 7955, SIDI OTHMANE, CASABLANCA, MOROCCO,   DEPARTMENT OF MATHEMATICS LASMA LABORATORY FACULTY OF SCIENCES DHAR EL MAHRAZ UNIVERSITY SIDI MOHAMED BEN ABDELLAH, FES, MOROCCO,   LABORATORY OF ALGEBRA ANALYSIS AND APPLICATIONS (L3A) HASSAN II UNIVERSITY OF CASABLANCA FACULTY OF SCIENCES BEN M’SIK AVENUE DRISS EL HARTI, B. P 7955, SIDI OTHMANE, CASABLANCA, MOROCCO
Published: April 2021

In this paper, we use Szaz maximum principle to prove generalizations of Caristi fixed point theorem in a ´ preordered K-complete quasi metric space. Examples are given to support our results.
Some properties of the analytic functions with bounded radius rotation
Authors:   DEPARTMENT OF MATHEMATICS AND COMPUTER SCIENCES ISTANBUL KULT ¨ UR¨ UNIVERSITY ISTANBUL, TURKEY, POLATOGLU YASAR , CETINKAYA ASENA ,   DEPARTMENT OF MATHEMATICS AND COMPUTER SCIENCES ISTANBUL KULT ¨ UR¨ UNIVERSITY ISTANBUL, TURKEY, MERT OYA ,   DEPARTMENT OF BASIC SCIENCES ISTANBUL ALTINBAS¸ UNIVERSITY ISTANBUL, TURKEY
Published: April 2021

In the present paper, we introduce a new subclass of normalized analytic starlike functions by using bounded radius rotation associated with q- analogues in the open unit disc \mathbb D. We investigate growth theorem, radius of starlikeness and coefficient estimate for the new subclass of starlike functions by using bounded radius rotation associated with q- analogues denoted by \mathcal{R}_k(q), where k\geq2, q\in(0,1).
Non-linear finite element analysis of a Ti6Al4V/Inconel 625 joint obtained by explosion welding for sub-sea applications
Authors: Corigliano Pasqualino
Published: April 2021

Industries have shown interest in the use of dissimilar metals to make corrosion-resistant materials combined with good mechanical properties in marine environments. Explosive welding can be considered a good method for joining dissimilar materials to prevent galvanic corrosion. The
aim of the present study was to simulate the non-linear behaviour of a Ti6Al4V/Inconel 625 welded joint obtained by explosion welding from the values of the tensile ultimate strength and yielding strength of the parent materials. The present study compared the stress-strain curve from tensile
loading obtained by the non-linear finite element analysis with the experimental stress-strain curve of a bimetallic joint. The applied method provides useful information for the development of models and the prediction of the structural behaviour of Ti6Al4V/Inconel 625 explosive welded joints.
Monitoring rocky reef biodiversity by underwater geo-referenced photoquadrats
Authors: Bravo Gonzalo , Livore Juan Pablo , Bigatti Gregorio
Published: April 2021

Digital images are an excellent tool for divers to sample hard-bottom subtidal habitats as bottom time is limited and high-definition images can be collected quickly and accurately. The present paper describes a sampling protocol for benthic rocky reef communities using geo-referenced
photoquadrats and tests the method over several rocky reefs of Atlantic Patagonia. This method was tested in two localities, separated by 100 km in a semi-enclosed gulf, covering a total of 5800 m of 11 rocky reefs using track roaming transects. The protocol is non-destructive, relatively
low-cost and can adequately assess changes in marine habitats as rocky reefs. The implementation of artificial intelligence analysis using human expert training may reduce analysis time and increase the amount of data collected. The present study recommends this sampling methodology for programs
aimed at monitoring changes in biodiversity.
Pengembangan Media Pembelajaran Fisika Menggunakan Software Aurora 3d Materi Pengukuran
Authors: Parwati Yuni , Nafisyah Dhurrotun
Published: April 2021

Tujuan penelitian: Penelitian ini meneliti bagaimana kontak sosial dan komunikasi sosial guru dan siswa dalam pembelajaran di sekolah dasar. Metodologi: Penelitian ini menggunakan metode deskriptif kualitatif. Informasi di dapat dari hasil observasi, wawancara, dan dokumentasi guru dan peserta didik. Temuan utama: Hasil penelitian bahwa interaksi sosial guru dengan siswa sudah baik. Keadaan interaksi sosial yang kurang baik di ketahui dari kontak sosial antara guru dan siswa pada saat pembelajaran. Dalam keadaan yang sudah baik ini, interaksi sosial guru dan siswa terlihat sudah sangat baik, situasi belajar yang semangat, dan adanya apresiasi guru dan siswa. Keterbaruan penelitian: Pendidikan ini berupaya meningkatkan interaksi sosial guru dan peserta didik melalui proses pembelajaran, terutama untuk meingkatkan sikap interaksi guru dan siswa demi menumbuh kembangkan interaksi sosial yang baik.
Translator Competence Revisited in the Scenario of Digital Genre
Authors: CHENG WEI
Published: April 2021

Abstract As the translation market is becoming increasingly diversified and digital genre is gradually prevailing over paper-based media in communication, user-centred translation is high on the agenda. According to Suojanen, Koskinen and Tuominen (2015), the two important
concepts behind user-centred translation are usability and user experience. Usability refers to the ease with which users can utilize a product to achieve their goals. User experience puts emphasis on the enjoyability experienced by users. While usability focuses on products being learnable
or memorable, user experience is a holistic concept encompassing issues such as aesthetics, fun, and pleasure. Based on the case study of international E-commerce sites, this research reveals that translators under the new circumstances should be even more empathic than those working with
paper-based media, which enables them to be versatile, adaptive, innovative and able to provide users with quality translation and enjoyable user experience.
From the Rise of Authentic Italian Restaurants in America to the Creation of New Multicultural Food Tourism Experiences
Authors: Campanari Alessandra , Cavicchi Alessio
Published: April 2021

With the emergence of culinary multiculturalism in the globalized world, ethnic restaurants have become central symbols of postmodern life, no longer relegated to a domestic and community sphere, but able to attract non-ethnic customers without necessarily destroy food cultural heritage. In line with this trend, the article aims to contribute to the literature on new food tourism experiences by examining contemporary Italian restaurants in the US to investigate how Italian food identity in ethnic restaurants is advertised and sold. Starting from the literature on Italian culinary immigration in America, from the rise of the first Italian restaurants to the invention of the Italian American culinary tradition, the article provides an ethnographic study to understand the changing business environment that is leading new entrepreneurs in foodservice to diversify their business models towards the creation of new food tourism experiences as a result of an ever-changing dialogue between tradition and innovation.
Phantom Demand and the Sake Market
Authors: McKercher Bob , Smith Ryan P. , Baldwin Watson , Ma Forest
Published: April 2021

This article examines sake consumption patterns in Hong Kong and reports on a study that seeks to determine if the market can be grown. Hong Kong is one of the major export markets for sake, driven largely by the popularity of Japanese restaurants. The Japanese Export and Trade Organizations
(JETRO) is looking at ways to expand consumption as a means of overcoming the decline in sake sales in Japan. This study presents a cautionary tale of market research, for on the surface the study reveals the market could grow by at least 25%, and more importantly, the current price point
is below what consumers are willing to pay. However, closer examination of the results suggests a much smaller growth potential for most of the people who consume sake do so once a month or less and usually in a restaurant setting. Increasing sales will require a change in overall dining and
drinking behavior patterns, which will be difficult to achieve.
Mindful Eating: Reinvigorating American Culinary Diaspora in a Low-income Community
Authors: Askew Alex
Published: April 2021

The culinary history of America is a rich melting pot of cultures from across the world, seasoned with the heritage of diasporas. This research note explores the existing culinary diaspora of American food and how the practice of mindful eating has prompted a revitalization. The author
examines how American cuisine is perceived and its connections with a dark period of the nation's past in the context of the "Beloved Community." There is a need to review the diasporas that gave rise to these culinary traditions that have stemmed from slavery and are endemic in low-income
communities. A better understanding can prompt a rethinking about how these communities can adopt mindful eating practices. This note extends the literature on culinary diasporas by reconsidering a beloved American culinary tradition.
Gullah Cuisine: Is It a Story of Cultural Appropriation or Cultural Appreciation?
Authors: Mitchell Kevin
Published: April 2021

As a chef, culinary historian, and resident of Charleston, South Carolina, USA, I have always been intrigued by the debate over the cultural appropriation , exploitation, and the appreciation of food from other cu l tures. It has always been important for me to know not only about food
and ingredients, but also the associated culture. In this article I take a sociological approach to discuss cultural appropriation as it relates to food. It also offers a meeting of my two worlds—as a professional chef and as a budding scholar.
PENGARUH PENGGUNAAN CODEC STANDART ITU G.729 TERHADAP SISTEM KOMUNIKASI VOIP
Authors: Prijono Wahyu Adi
Published: April 2021

Voice over Internet Protocol (VoIP) is a technology that is capable of passing voice traffic, in the form of packets through the network Internet Protocol (IP). IP network itself is a data communications network based packet-switch. The voice signal before experiencing bundled voice coding or format conversion of sound into digital form that can be passed over an IP network. Telephony, Internet telephony, or termed VoIP (Voice Over Internet Protocol.This communication system use VoIP (Voice over Internet Protocol), ie voice calls over data services (internet). This communication was developed using Android-based devices. Based on characteristics, android devices are open source, so users do not need to have a license to be able to have android-based devices. In addition, the android device that must be connected to a SIP (Session Iniation Protocol) is a data service that can be done with a paid subscription of the user of the operator using a conventional pulse. Telecommunications designed will use a hybrid system, the merger between VoIP communications with data communications GSM network. With basic calculations where Coding standards G 729, is a standard that can be used for voice communication system through data networks with rate of 8 Kbps. The implementation of the G729 codec is effect on communication systems VOIP.
MATHEMATICAL MODEL TO PREDICT SEVERITY OF CORONAVIRUS INFECTION AND MAIN ANTI-EPIDEMIC MEASURES IN UKRAINE
Authors: Kryvonos K. A. , Maslova V. S. , Sharapov V. M. , Vorobyov S. M.
Published: April 2021

Currently, the epidemic situation regarding the incidence of coronavirus infection COVID−19 in Ukraine continues to be tense. In order to in−depth study of the problem of clinical features, treatment and prevention of this disease, as well as the development of a mathematical model for predicting the severity of its course, 30 patients aged 18 to 85 years were examined. Among the patients there were young and middle−aged people as well as elderly patients with chronic diseases, namely obesity, hypertension, diabetes. The diagnosis of coronavirus infection was confirmed in all the patients by molecular genetic method, i.e. SARS−CoV−2 RNA was isolated, and in 10 patients − IgM + IgG to SARS was determined by immunochromatographic analysis. With COVID−19, young and middle−aged patients have a fairly mild course with a decrease in platelet count by 7 %, erythrocyte sedimentation rate by 48 %, prothrombin by 14 % and D−dimer by 31 %. The construction of regression equations based on trend lines revealed that in elderly patients after treatment there was a further decrease in the level of D−dimer (20 %), an increase in platelet count (30 %), a decrease in white blood cell count (26 %), neutrophils (38 %), increase in lymphocyte levels by 3 times, decrease in erythrocyte sedimentation rate (by 10 %) and prothrombin parameters (by 15 %). Based on cluster and regression analysis, coefficients were calculated for each prognostic function. It was found that the linear dependence and statistically significant effect on the course of COVID−19 in all patients have leukocytes, erythrocyte sedimentation rate and D−dimer. In order to prevent the spread of coronavirus infection in Ukraine COVID−19 in this March, quarantine was introduced throughout the country, which is being extended to this day. There is no doubt about the importance of recommendations for improving anti−epidemic measures to prevent coronavirus infection throughout Ukraine. Key words: coronavirus infection, COVID−19, clinical blood counts, disease prognosis, anti−epidemic measures in Ukraine.
CLINICAL AND THERAPEUTIC VALUE OF ADIPOKINES IN PATIENTS WITH CHRONIC KIDNEY DISEASE
Authors: Fylenko Ya. M
Published: April 2021

This review is devoted to the analysis of the role of adipokines in formation of pathological changes in renal function and structure. The patients with chronic kidney disease have a high risk of cardiovascular disease. Currently, the role of systemic hormonal and metabolic factors in the pathogenesis of the kidneys is growing. A promising area of pathogenetic prevention and treatment of kidney disease is an interdisciplinary approach, whereat the adipokine imbalance is of particular interest. Adipose tissue and its messengers, adipokines, are known to be highly associated with kidney disease. Adipocytes are metabolically active cells, producing the signaling lipids, metabolites and protein factors, i.e. adipokines. The interaction of adipose tissue with the kidney is called the adipose kidney axis, being important for the normal functioning of the body, as well as its response to an injury. It has a strong therapeutic potential in respect of the growing rates of chronic kidney disease. Adipocyte hypertrophy is often accompanied by the development of tissue fibrosis, hypoxia, and secretion of pro−inflammatory cytokines (such as tumor necrosis factor or interleukin, which triggers the cell inflammation). Dysfunction of adipose tissue contributes to the development of cardiovascular disease at the local and systemic levels. Thus, for the early diagnosis of chronic kidney disease into the diagnostic program, in addition to the generally accepted indices, the determination of adipokines: for example, serum leptin, adiponectin, omentin, visfatin, microalbuminuria, blood lipid spectrum, intrarenal and functional status of the kidneys with the assessment of functional renal reserve is recommended to be included. Early detection of the disease, new approaches to its diagnosis and treatment can help in reducing the risk of a high incidence and mortality from renal disease.

Key words: chronic kidney disease, nephropathy, adipokines, leptin, resistin, adiponectin, visfatin, omentin.
FEATURES OF CAPILLARY BLOOD FLOW IN PATIENTS WITH PATHOLOGY OF INTRANASAL STRUCTURES AND NASAL BREATHING DISORDERS
Authors: Shushliapina N. O. , Cherniakova O. Ye.
Published: April 2021

The investigation of the vascular microcirculation system is important for diagnosis, assessment of the severity and nature of pathological processes in human body, monitoring the effectiveness of treatment. Monitoring the state of microcirculation in impaired respiratory function of the nose helps to study the subtle mechanisms of regulation of vascular−tissue relations. To do this, there were used the biomicroscopic methods to study capillary blood flow, one of the most relevant and promising is optical capillaroscopy of the nail bed. This method makes it possible to identify at the evidence level the peculiarities of the functioning of the peripheral circulatory system by the state of the capillary system and to evaluate the effectiveness of treatment by the rheological properties of blood in hematological practice. There were examined 145 patients by means of computer capillaroscopy to study the rate of capillary circulation in the patients with pathology of intranasal structures and nasal breathing disorders. All patients underwent a complete clinical examination, routine instrumental examinations, and computer capillaroscopy using a video capillaroscope with a visual magnification of up to 550 times. The obtained images were stored and processed according to a special software. During the characterization of the capillaroscopic picture there were evaluated: pathological tortuosity, change in the caliber of arterioles and venules, disorganization of the capillary network, the number of functioning capillaries. Changes in the speed and nature of capillary blood flow (accelerated, slow, stasis) were observed. The optical capillaroscopy method allows not only to visually assess the condition of microvessels, but also to determine such an important parameter as blood circulation, actually, it can replace the study of laser Doppler. Such data will be important in the diagnosis of respiratory and olfactory disorders and the formation of adequate tactics for their treatment. Key words: microcirculation, microcirculatory tract, capillary circulation, nasal obstruction, nasal breathing disorders, pathology of intranasal structures, computer capillaroscopy.
INDICATIONS FOR PANCREATODUODENAL RESECTION IN TREATMENT OF CHRONIC PANCREATITIS COMPLICATED FORMS
Authors: Arutyunov S. E. , Klymenko M. V. , Shamoun K. E.
Published: April 2021

Chronic pancreatitis is a recurrent progressive disease accompanied by fibrosis and fibrocystic degeneration of the pancreatic parenchyma. There are remained the unexplored issues of progression of fibrosis in the pancreas parenchyma, which lead to a rapid enlargement of the head, the development of complications that require a resection surgery. To develop a differentiated approach to the choice of surgical treatments and indications for pancreatoduodenal resection in complicated forms of chronic pancreatitis, a study was performed in 137 patients underwent resection and drainage surgery. Pancreatoduodenal resection was accomplished in 12 patients. Instrumental research methods were used: multidetector (64−slice) computed tomography with 3D reconstruction, magnetic resonance imaging, magnetic resonance cholangiopancreatography, endoscopic retrograde cholangiopancreatography. Two clinical examples are given. Indications for pancreatoduodenal resection in patients with chronic pancreatitis were expressed fibro−inflammatory process in the area of the pancreas head, suspected development of oncological pathology. Progressive fibrotic changes in the pancreas parenchyma, mainly in the head, occurring in some patients, associated with stellate cell activation and fibrogenesis, they lead to the development of biliary and portal hypertension, stimulation of oncogenesis. It is concluded that with the progression of fibro−inflammatory process in the pancreas head with the development of complications (pancreatic, biliary and portal hypertension), as well as in case of impossibility to exclude the tumor, the surgery of choice is pancreatoduodenal resection. The presence of severe fibrosis in the pancreas parenchyma reduces the risk of developing pancreatic fistula when performing pancreatoduodenal resection.

Key words: complicated forms of chronic pancreatitis, pancreatoduodenal resection, fibro−inflammatory process, pancreatic fistula
FEATURES OF CLINICAL MANIFESTATIONS OF POST-TRAUMATIC NEUROPATHIES AND PLEXOPATHIES RESULTED FROM GUNSHOT AND NON-GUNSHOT INJURIES OF EXTREMITIES
Authors: Borodai O. M. , Kas Yu. V.
Published: April 2021

The number of traumatic injuries to nerve stems and plexuses is steadily increasing in peacetime during armed conflicts and terrorist acts. In wartime, peripheral nerve injuries are much more common, and a great deal of the knowledge about peripheral nerve damage and repair is based on combat experience. The study of the clinical course of post−traumatic neuropathies and plexopathies contributes to the development of clinical and neurological criteria and compensatory−restorative responses in traumatic lesions of the peripheral nervous system, helps to assess the functional significance of various parts of the nervous system when compensating a damaged functional unit. To study the features of clinical manifestations of post−traumatic gunshot and non−gunshot neuropathies and plexopathies, 63 patients underwent clinical and neurological examination with topical and clinical diagnoses, collection of detailed anamnesis and complaints, electroneuromyography and ultrasound examination. Movement disorders, characterized by peripheral paresis or plegia of the corresponding muscle group and accompanied with a reduced or lost tendon and periosteal reflexes, were common. Sensitivity disorders were a combination of prolapse (anesthesia, hypoesthesia) and irritation (paresthesia, hyperpathy, hyperesthesia). Autonomic disorders (vascular, secretory and trophic) in traumatic neuropathies differ depending on the clinical individuality of peripheral nerves. Vascular disorders were more often detected with partial damage to nerve structures and were accompanied by local edema. Of the secretory disorders, the most constant sign of impaired nerve conduction was sweating disorder. In the clinical picture of the pain syndrome, i.e. causalgia, the pain sensations by type of burning dominated. The intensity of the pain syndrome in severe cases was very high, in some cases the pain was exacerbated by irritation of the senses. The clinical picture of causalgia is characterized by an increased pain when warming the injured limb and it reduced when cooled, that is a "symptom of a wet rag." Knowledge of clinical features allows the detection of the peripheral nervous system lesions at the early stages of pathology, performance of dynamic clinical and neurological observation and treatment, timely use of modern additional research methods to address further treatment tactics that restore limb function, improve quality of life.

Key words: post−traumatic neuropathy and plexopathy, peripheral nervous system, gunshot wounds of nerves and plexuses.
PREMATURE AGING INDICES IN PATIENTS WITH MODERATE CARDIOVASCULAR RISK
Authors: Radchenko A. O. , Bondar T. M. , Potapenko A. V.
Published: April 2021

Aging is characterized with a gradual aggravation of organ function throughout life and can occur both physiologically and prematurely. With premature aging there is an early decrease in the adaptive mechanisms of all physiological systems of the body, there is a significant reduction in physical and mental activities, that contributes to the early development of age−related pathology. Genetic and epigenetic factors, as well as environmental ones can be the causes of different rates of aging. It is not possible to accurately determine the onset of old age by biological characteristics, because people with the same calendar age are not always the same as for biological one. To establish the association of age−related disease factors with the markers of premature aging and biological age in the patients of various age groups, a study was performed in the patients aged 25−44 and 45−59 years with moderate cardiovascular risk in accordance with the SCORE scale. The primary task for predicting and preventing the age−associated diseases is to identify genetic, molecular and cellular factors that determine the rate of aging and increase the risk of age−associated diseases. The role of cardiovascular risk factors in premature aging has been determined. It is established that the most important factors that lead to an increase in biological age and formation of age−associated diseases are the disorders of lipid and carbohydrate metabolism and level of oxidative stress, importance of which progresses with age. The relationship between cardiovascular risk factors and biological age, estimated with different methods, their influence on telomere length, that allows the designing of an algorithm to determine the markers of premature aging in different age groups for early and effective prevention of metabolic−associated diseases, has been established.

Key words: biological age, cardiovascular risk, premature aging, telomere length.
COMPARATIVE ANALYSIS OF NEUROPHYSIOLOGICAL FEATURES IN YOUNG WOMEN AND MEN SUFFERING FROM EPILEPSY
Authors: Voitiuk A. О. , Litovchenko T. А.
Published: April 2021

The definition of epilepsy via the concept of neuronal discharge indicates the crucial importance of electroencephalography (EEG) in epileptology. This pathology is a certain problem for each sex, that requires gender−specific approaches when managing and treating such patients. To investigate them, 30 men and 30 women aged 18−44 years with a reliable diagnosis of epilepsy were examined. A comprehensive clinical, neurological and neurophysiological study of patients was performed, taking into account the data of clinical case and life history. Each patient was assessed for neurological status according to traditional methods, electrophysiological method of examination (routine EEG) was used. On the results of electroencephalography in individuals of both sexes with epilepsy, there was a decrease in the amplitude of the α−rhythm, but a significant slowdown in this rhythm was not detected. Most patients had high−amplitude (> 20 μV) and low−frequency β1−rhythm. Low−frequency high−amplitude slow−wave activity was regarded as an EEG reflection of degenerative−dystrophic processes in brain. Photostimulation caused paroxysms of bilaterally synchronous sharp and slow waves, complexes of "acute−slow" wave. Hyperventilation led to an increase in the θ−rhythm amplitude, appearance of δ−waves, higher expression of true epileptiform phenomena: adhesions, "acute wave−slow wave" complexes, "spike−slow wave" complexes. A comparative analysis of the obtained results allowed to conclude that the changes in bioelectrical activity in epilepsy occur according to the general mechanisms of epileptogenesis, regardless of gender. Key words: epilepsy, electroencephalogram, comparative analysis, young men and women.
MAIN ISSUES OF CHILDREN'S INCIDENCE OF ACUTE OTITIS MEDIA AND PROSPECTS TO SOLVE THEM
Authors: Kulikova O. O. , Lozova Yu. V.
Published: April 2021

The problem of acute otitis media in children is relevant because of the prevalence, social significance, possibility of rapid development of both life−threatening intracranial and intralabyrinthine, mastoid complications, as well as acute or prolonged dysfunction of adjacent cranial nerves, especially auditory, vestibular ones. In order to determine the frequency of various forms of acute otitis media, the nature and extent of its complications in children of different ages there was conducted a retrospective analysis of medical histories of patients treated at the City Clinical Hospital № 30 Kharkiv within 2015−2019. There was stated that the biggest group was composed by the patients with a purulent form of the disease, a slightly smaller number of patients had secretory and viral processes. But when analyzing the data over the years, of interest is the fact that during the period when the number of purulent forms decreased, the number of viral ones increased. Complications include mastoiditis, acute sensorineural hearing loss, cerebrospinal fluid and hypertension and intoxication syndromes. It is important that in acute purulent and viral otitis there is an intoxication syndrome along with the manifestations of acute sensorineural hearing loss. Signs of vestibular dysfunction in children can be disguised as symptoms of intoxication, they are much more difficult to detect. Considering the fact that the snail and the labyrinth are washed by the same liquid, it is logical to assume that in this situation the vestibular analyzer suffers together with the auditory one. Therefore, along with otoneurological research it is necessary to apply instrumental methods for establishment of latent disturbances of function of the vestibular analyzer. According to the research results it was concluded that a more detailed study of vestibular analyzer dysfunction in children with acute otitis media, as they are disguised as symptoms of intoxication.

Key words: acute otitis media, frequency, complications, vestibular disorders, children.
CLINICAL CHARACTERISTICS OF PATIENTS WITH CHRONIC HEART FAILURE AND TYPE 2 DIABETES MELLITUS WHO REQUIRE IMPLANTATION OF PERMANENT PACEMAKER
Authors: Voronenko O. S. , Brynza M. S.
Published: April 2021

In recent decades, there has been a rise of chronic heart failure mortality. Among the huge range of modern methods of this pathology treatment, the cardioresynchronizing therapy stands out, it allows the improvement of the patient's heart function, reduces clinical signs of the disease, improves well−being, as well as diminishes morbidity and mortality. The use of this method in the patients with a comorbid pathology, i.e. in those with chronic heart failure and type 2 diabetes, deserves a special attention. In order to determine the clinical characteristics of the patients who required a pacemaker implantation, we examined 203 patients who had reasonable indications for this in accordance with the ACC / ANA and ESC current recommendations. Another important criterion for inclusion into the group of implantation was considered to be the presence of comorbid Diabetes mellitus type 2. The gender and age characteristics of the surveyed population were dominated by elderly male patients. The presence of concomitant cardiovascular pathology depending on the age of patients was analyzed, which showed mostly hypertension of stage 2−3, a constant atrial fibrillation. In structure of comorbid pathology the somatic diseases, including type 2 Diabetes mellitus prevailed. Electrostimulators were implanted into the examined cohort of patients, among which 132 devices worked in DDD mode, 71 of the installed stimulators had the DDDR mode. The research results concluded that the implantation of a pacemaker became a necessary procedure for elderly patients, mostly men, with a high prevalence of cardiovascular (coronary heart disease, hypertension, persistent atrial fibrillation) and somatic pathology in the form of type 2 Diabetes mellitus.

Key words: chronic heart failure, type 2 diabetes mellitus, pacemaker implantation, clinical features, gender and age characteristics.
FACTORS OF PERIOPERATIVE MORTALITY IN PATIENTS WITH GROWING RENAL CELL CARCINOMA IN INFERIOR VENA CAVA LUMEN
Authors: Makovozov O. O. , Antonian I. M. , Khareba G. G. , Stetsyshyn R. V. , Maltsev A. V. , Mozzhakov P. V.
Published: April 2021

Difficult surgical cases of tumors of the inferior vena cava occur very often, because this intervention is characterized with technical difficulties and severe intraoperative complications. The most dangerous of these include massive bleeding, acute heart failure, and pulmonary embolism by tumor masses, which are the most common causes of perioperative mortality. Vena cava trombectomy is a special operation that can be accompanied by heavy bleeding at virtually any stage. The causes and frequency of mortality in 108 patients operated for renal cell carcinoma with growing to the inferior vena cava were retrospectively analyzed. Reliable factors for the prognosis of perioperative mortality in this pathology have been identified. Factors that characterize the tumor thrombus features, as well as parameters related to general condition of a patient, have been found to be of the greatest importance. The results of the study showed that the level of perioperative mortality in caval tumor thrombi is 8.3 % when using surgical methods without artificial circulation. The presented patient population contained a significant proportion of so−called "high" thrombi of III−IV levels, thrombi invading the wall of the inferior vena cava, as well as retrograde spread of intraluminal tumor. The main causes of death were acute heart failure, intraoperative bleeding, pulmonary embolism with tumor masses and acute renal failure. The prognostic value of perioperative mortality was demonstrated by the following thrombus factors: its "high" level, invasion of intraluminal tumor into the caval wall, signs of complete obstruction of caval blood flow. The mortality rate was objectively affected by severe heart failure, signs of pulmonary embolism before surgery.

Key words: inferior vena cava, tumor thrombus, renal cell carcinoma, vena cava trombectomy, lethality.
A-b Ridge Count and Its Correlation with Epilepsy
Authors: Rashmi C Goshi
Published: April 2021

The study of ridges of skin is called dermatoglyphics. It is recognized as a valuable method for medicolegaland anthropological studies. The permanency of the finger patterns, the extreme variability from oneindividual to the other and easy analysis are some of the reasons for its wide applications in a varietyof conditions. Dermatoglyphic patterns are determined by genetic factors. It has been proved that geneticfactors are responsible for idiopathic epilepsy. Hence there is a scope for the study of relationship betweenepilepsy and dermatoglyphic patterns.Objectives : • To study the A-b ridge count in generalized tonic clonic seizure patients.• To compare this dermatoglyphic configuration of cases with the normal population.Methods : The ink method was followed to take finger and palm prints. The palmar prints of 50 epilepticpatients and 50 normal individuals of both sexes were collected for the study.Conclusion: There is no significant association found between a-b ridge count and epilepsy patients whencompared to normal.