bluuebunny/crossref_metadata_2025 huggingface dataset:
Cytonuclear diversity underlying clock adaptation to warming climate in wild barley ( Hordeum vulgare ssp. spontaneum )
Authors: Fridman Eyal , Tiwari Lalit , Bdolach ُEyal , Prusty Manas , Bodenheimer Schewach , Doron-Faigenboim Adi , Yamamoto Eiji , Kashkush Khalil
Published: February 2023

In plants, the contribution of the plasmotype (mitochondria and
chloroplast) in controlling of the circadian clock plasticity and
possible consequences on cytonuclear genetic make-up has not been fully
elucidated. Here, we investigated the cytonuclear genetics underlying
thermal plasticity of clock rhythmicity and fitness traits in reciprocal
hybrid (RH) and B1K diversity panels of wild barley ( Hordeum
vulgare ssp. spontaneum). Phenotypic analysis of the RH panel,
showed higher abundance of plasmotype effects on chlorophyll
fluorescence and its rhythmicity than plant phenology and growth.
Performing a genome wide association study in the B1K panel found
overlap with previously reported drivers of clock ( DOC)
loci yet due to intra-chromosomal linkage disequilibrium these loci
encompass shorter intervals. Moreover, by incorporating long-range
chloroplastic sequencing we identified significant inter-chromosomal
linkage disequilibrium and epistatic interactions between previously
DOC3.2 and 5.1 loci and the chloroplastic RpoC1
genes, indicating adaptive value for specific cytonuclear gene
combinations. Finally, heterologous over-expression of two barley
RpoC1 alleles in Arabidopsis showed significantly
differential plasticity under elevated temperatures. Our results unravel
previously unknown cytonuclear interactions as well as alleles within
the chloroplastic genome that control clock thermal plasticity.
Effects of Semaglutide on Albuminuria and Kidney Function in People With Overweight or Obesity With or Without Type 2 Diabetes: Exploratory Analysis From the STEP 1, 2, and 3 Trials
Authors: Heerspink Hiddo J.L. , Apperloo Ellen , Davies Melanie , Dicker Dror , Kandler Kristian , Rosenstock Julio , Sørrig Rasmus , Lawson Jack , Zeuthen Niels , Cherney David
Published: February 2023

OBJECTIVE

These post hoc analyses of the Semaglutide Treatment Effect in People with obesity (STEP) 1–3 trials (NCT03548935, NCT03552757, and NCT03611582) explored the effects of semaglutide (up to 2.4 mg) on kidney function.

RESEARCH DESIGN AND METHODS

STEP 1–3 included adults with overweight/obesity; STEP 2 patients also had type 2 diabetes. Participants received once-weekly subcutaneous semaglutide 1.0 mg (STEP 2 only), 2.4 mg, or placebo for 68 weeks, plus lifestyle intervention (STEP 1 and 2) or intensive behavioral therapy (STEP 3). Changes in urine albumin-to-creatinine ratio (UACR) and UACR status from baseline to week 68 were assessed for STEP 2. Changes in estimated glomerular filtration rate (eGFR) were assessed from pooled STEP 1–3 data.

RESULTS

In STEP 2, 1,205 (99.6% total cohort) patients had UACR data; geometric mean baseline UACR was 13.7, 12.5, and 13.2 mg/g with semaglutide 1.0 mg, 2.4 mg, and placebo, respectively. At week 68, UACR changes were −14.8% and −20.6% with semaglutide 1.0 mg and 2.4 mg, respectively, and +18.3% with placebo (between-group differences [95% CI] vs. placebo: −28.0% [−37.3, −17.3], P < 0.0001 for semaglutide 1.0 mg; −32.9% [−41.6, −23.0], P = 0.003 for semaglutide 2.4 mg). UACR status improved in greater proportions of patients with semaglutide 1.0 mg and 2.4 mg versus placebo (P = 0.0004 and P = 0.0014, respectively). In the pooled STEP 1–3 analyses, 3,379 participants had eGFR data; there was no difference between semaglutide 2.4 mg and placebo in eGFR trajectories at week 68.

CONCLUSIONS

Semaglutide improved UACR in adults with overweight/obesity and type 2 diabetes. In participants with normal kidney function, semaglutide did not have an effect on eGFR decline.
Non-invasive hypoglycemia detection in people with diabetes using smartwatch data
Authors: Lehmann Vera , Föll Simon , Maritsch Martin , van Weenen Eva , Kraus Mathias , Lagger Sophie , Odermatt Katja , Albrecht Caroline , Fleisch Elgar , Zueger VThomas , Wortmann Felix , Stettler Christoph
Published: February 2023

  

Aim

To develop a non-invasive hypoglycemia detection approach using smartwatch data.

Research Design and Methods

We prospectively collected data from two wrist-worn wearables (Garmin vivoactive 4S; Empatica E4) and continuous glucose monitoring values in adults with diabetes mellitus on insulin treatment. Using this data, we developed a machine learning (ML) approach to detect hypoglycemia (<3.9 mmol/L) non-invasively on unseen individuals and solely based on wearable data.

Results

Twenty-two individuals were included in the final analysis (age 54.5±15.2y, HbA1c 6.9±0.6%, 16 male). Hypoglycemia was detected with an area under the receiver operating characteristic curve of 0.76±0.07 solely based on wearable data. Feature analysis revealed that the ML model associated increased heart rate, decreased heart rate variability, and increased tonic electrodermal activity with hypoglycemia.

Conclusions

Our approach may allow for non-invasive hypoglycemia detection using wearables in people with diabetes and thus complement existing methods for hypoglycemia detection and warning.

 
Media Kober (Kotak Berhitung) Berbasis Permainan Spin Wheel pada Muatan Matematika
Authors: Gusti Ayu Diah Ariesta Dewi  , Ni Wayan Rati  , Gusti Ayu Putu Sukma Trisna
Published: February 2023

Masalah yang paling umum adalah siswa merasa matematika sulit dan tidak menyenangkan. Media pembelajaran yang digunakan masih kurang memadai berpengaruh pada hasil belajar menurun. Tujuan penelitian ini yaitu mengembangkan media kober (kotak berhitung) berbasis permainan spin wheel pada muatan matematika. Jenis penelitian yaitu pengembangan dengan metode ADDIE (Subjek penelitian yaitu 2 ahli isi dan 2 ahli media. Subjek uji coba yaitu 2 praktisi dan 30 siswa. Metode pengumpulan data antara lain observasi, wawancara kuesioner, dan tes tertulis. Instrument yang digunakan yaitu rating scale. Teknik analisis data yaitu analisis deskriptif kualitatif, analisis deskriptif kuantitatif dan analisis statistik inferensial (uji-t). Hasil penelitian yaitu hasil dari ahli konten 93,75 sangat baik dan praktisi yaitu 95,2% sangat baik.  Hasil  uji coba perorangan 96,1 sangat baik, kelompok kecil 95,1% sangat baik dan uji coba lapangan 95,8% sangat baik. Hasil ini uji-T yaitu 0,05 (p<0,05), sehingga terdapat perbedaan yang signifikan antara sebelum dan sesudah menerapkan media yang dikembangkan. Disimpulkan media pembelajaran Kober (kotak berhitung) berbasis permainan spin wheel efektif untuk digunakan dalam pembelajaran di kelas IV Sekolah Dasar.
Aplikasi Android Belajar Membaca (KEJARBACA): Minat Membaca Siswa Kelas III Sekolah Dasar
Authors: Luh Lista Santi Widiani  , Putu Nanci Riastini  , Dewa Gede Firstia Wirabrata
Published: February 2023

Permasalahan saat ini yaitu minat membaca siswa yang sangat rendah.  Beberapa siswa menganggap kegiatan membaca sangat membosankan. Tujuan penelitian ini yaitu menghasilkan aplikasi android belajar membaca (KEJARBACA) yang dapat meningkatkan minat membaca pada siswa sekolah dasar. Jenis penelitian ini yaitu research and development menggunakan model ADDIE. Aplikasi KEJARBACA yang telah dikembangkan kemudian dilakukan uji validasi oleh 2 para ahli. Populasi penelitian berjumlah 6 orang, dan sampel penelitian berjumlah 6 orang. Metode pengumpulan data yang digunakan yaitu observasi, kuesioner, dan studi dokumentasi. Instrument yang digunakan dalam mengumpulkan data yaitu lembar rating scale. Teknik yang diguakan dalam menganalisis data yaitu deskriptif kualitatif, kuantitatif, dan statistic inferensial. Hasil penelitian yaitu hasil penilaian dari ahli isi produk mendapatkan validitas sangat tinggi. Hasil penilaian dari guru sangat tinggi, dan siswa validitas sangat tinggi. Hasil uji efektifitas menunjukan terdapat hasil yang signifikan peningkatan minat membaca siswa. Disimpulkan bahwa aplikasi android belajar membaca (KEJARBACA) dapat meningkatkan minat membaca pada siswa sekolah dasar.
Research on the Influencing Factors of Consumers’ Loyalty to Their Bank in Azerbaijan
Authors: Rustamov Samir
Published: February 2023

Today, banks are developing very rapidly, the variety of products and services is increasing and the competition between banks is intensifying. Meeting the needs and expectations of customers arising from banking services is essential both to retain existing customers and to gain new customers. For this reason, the concept of customer loyalty has increased its importance in the banking sector. The increase in competition conditions in the banking sector makes customer orientation inevitable in banks. The fact that the product variety in the banking sector is almost the same in all banks requires banks to make a great effort for customer loyalty. The main purpose of this research is to determine the relationship between bank choosing criteria and customer loyalty in Azerbaijan, and how this relationship changes because of demographic factors. Therefore, the study possesses two objectives; firstly, to examine the relationship between bank related influencing factors and customer loyalty. Secondly, to determine how educational and income level of respondents affect this relationship. Data was obtained through convenience sampling, from a sample of 192 respondents by using a self-administered questionnaire. SPSS Amos was used to analyze the collected data. Based on the mean calculation questionnaire results were analyzed to assess the cause-result relationship between bank related influencing factors and customer loyalty. A t-test was used to analyze whether those factors differ significantly according to education level, while Analysis of variance test and Tukey test were performed to analyze whether the variables differ significantly according to monthly income. As a result of research, it has been revealed that employee behavior, bank products accessibility and product diversity have positive effect on customer loyalty, while the interior and exterior view of banks do not significantly affect customer loyalty. Additionally, the research suggests that in contrast to the relationship between employee behavior and customer loyalty, in all other cases, individuals with a higher level of education and higher monthly income consider more factors when choosing a bank.
PENGUKURAN KINERJA KEUANGAN PERUSAHAAN DENGAN CASH FLOW RATIOS ANALYSIS
Authors: Tulasi Daniel , Yuniarto Antonius
Published: February 2023

Masalah pemutusan hubungan kerja karyawan pada perusahaan tekstil dan produk tekstil di Indonesia sedang menjadi topik diskusi pada beberapa bulan terakhir. Permasalahan tersebut menarik perhatian para pemerhati untuk mengevaluasi kinerja dan membuat estimasi tentang prospek kondisi industri tekstil pada masa depan. Kinerja keuangan perusahaan menjadi salah satu aspek penting yang patut dievaluasi untuk dijadikan pertimbangan dalam rangka pembuatan strategi perusahaan. Tujuan penelitian ini, 1) untuk mengetahui kemampuan rasio-rasio cash flow dalam membedakan kinerja keuangan perusahaan yang sehat dan tidak sehat; 2) untuk menidentifikasi variabel predictor yang memberikan kontribusi paling besar bagi perbedaan kinerja keuangan perusahaan yang sehat dan tidak sehat. Sampel yang dipilih sebanyak 40 perusahaan dimana 20 perusahaan terindikasi mengalami kesulitan keuangan dan 20 perusahaan dinilai dalam kondisi sehat. Data dikumpulkan dari laporan keuangan perusahaan selama tiga tahun yakni tahun 2017 sampai 2019. Pengolahan data dilakukan dengan analisis diskriminan. Hasil penelitian menunjukkan 1) rasio-rasio aliran kas mampu menjelaskan perbedaan kinerja antara perusahaan yang sehat dan tidak sehat; 2) variabel cash flow to adequacy ratio merupakan variabel predictor yang memberikan kontribusi paling tinggi bagi perbedaan antara perusahaan yang sehat dan tidak sehat.
Developing online teaching and learning
Authors: Forbes Diane
Published: February 2023

Trendsetter Presentation https://doi.org/10.26188/22106807.v1

 

As an enthusiastic online teacher for more than two decades, I have learned a great deal over the years. This presentation will highlight a few selected lessons, from early realisations to covid-inspired learning. I will share a little of what I have learned from working with esteemed collaborators, including a glimpse of university students’ online learning experiences, and insights into developing online teaching in higher education through continuing professional learning.

On the basis of research and experience, this presentation will draw parallels between learning online and learning to teach online. Key themes discussed will include diversity, agency, social learning, creativity, and continuity.

Participants will be invited to reflect upon their own experiences and epiphanies as online teachers and learners.
Implicaciones de la potencial elevación del nivel del mar para la población costera de Tabasco, México
Authors: Gama Campillo Lilia María , Díaz López Hilda María , Collado Torres Ricardo , Macías Valadez Treviño María Elena , Mata Zayas Ena Edith , Figueroa MahEng José Manuel
Published: February 2023

El incremento del nivel del mar se ha acelerado por el calentamiento global. Las zonas más amenazadas son las pequeñas islas y las planicies costeras. Tabasco se localiza en una llanura costera inundable. Utilizando información demográfica, valores de erosión costera y datos globales de elevación del nivel del mar, se identificó el área, y las localidades en ella, entre cero y un metro sobre el nivel del mar. Los resultados indican que 55.58% de la superficie estatal está en este rango. La potencial pérdida de territorio podría afectar a 76 localidades, transformando las posibles actividades productivas que se realicen.
Metrópolis y diversidad sexual: una reflexión diagonal y latinoamericana
Authors: Almeida Vinicius Santos , Larreche José Ignacio
Published: February 2023

En Latinoamérica, la diversidad sexual, salvo raras excepciones, ha estado ausente en la reflexión sobre lo metropolitano hasta el siglo en curso. En ese sentido, las siguientes páginas reseñan las particularidades de este tema en algunas grandes ciudades del sur desde una mirada espacial y sociocultural. Para ello se acuña una perspectiva diagonal del territorio urbano con base en anclajes simbólicos, en diálogo con ejemplos que se desprenden del análisis bibliográfico y una pesquisa en São Paulo. Esta propuesta toma a la urbanidad como llave de entrada para pensar en una geografía urbana resignificada.
Kiedy wybieram mebewerynę?
Authors: Waśko-Czopnik Dorota
Published: February 2023

Zespół jelita drażliwego (IBS, irritable bowel syndrome) jest jednym z najczęstszych zaburzeń czynnościowych przewodu pokarmowego stanowiącym wciąż problem diagnostyczny i terapeutyczny. Aktualne dane naukowe w odniesieniu do farmakoterapii sugerują wysoką skuteczność leczenia rozkurczowego np. mebeweryną w połączeniu z innymi lekami prokinetycznymi i rozkurczowymi stosowanymi doraźnie oraz anksjolitykami w razie potrzeby, nie zapominając o indywidualnej diecie i modyfikacji stylu życia. IBS nadal stanowi wyzwanie diagnostyczne ze względu na dynamicznie zmieniający się obraz kliniczny i interdyscyplinarność choroby, jest rozpoznaniem z wykluczenia, w którym leczenie dostosowujemy do objawów aktualnie dominujących.
Mianseryna – miejsce i rola w leczeniu depresji
Authors: Parnowski Tadeusz
Published: February 2023

Podstawową grupą leków stosowanych w terapii zaburzeń depresyjnych są inhibitory wychwytu zwrotnego serotoniny, jednak nie we wszystkich przypadkach mogą one zostać zastosowane. Ograniczenia w przyjmowaniu leków z tej grupy występują np. u pacjentów z chorobami kardiologicznymi. Dodatkowo u części pacjentów występuje oporność na inhibitory wychwytu zwrotnego serotoniny. W takich sytuacjach zaleca się stosowanie starszych preparatów, przeważnie w ramach leczenia skojarzonego. W pracy przedstawiono przypadki zastosowania mianseryny należącej do starszej generacji leków przeciwdepresyjnych.
Cefiksym – doustna cefalosporyna III generacji
Authors: Doboszyńska Anna
Published: February 2023

Cefiksym jest półsyntetycznym antybiotykiem β-laktamowym, cefalosporyną III generacji do stosowania p.o. Wykazuje działanie bakteriobójcze, mechanizm działania polega na hamowaniu biosyntezy ściany komórkowej bakterii. Spektrum działania: Streptococcus pyogenes, Haemophilus influenzae, Moraxella catarrhalis, Proteus mirabilis. Omówiono wskazania do zastosowania cefiksymu: leczenie zakażeń wywołanych przez wrażliwe drobnoustroje u dorosłych, młodzieży i dzieci po 6. m.ż. Wskazania u dorosłych chorych: zaostrzenie przewlekłego zapalenia oskrzeli, pozaszpitalne zapalenie płuc, zapalenie dolnych dróg moczowych, odmiedniczkowe zapalenie nerek, zapalenie ucha ś rodkowego, zapalenie zatok, zapalenie gardła. W artykule opisano trzy przypadki zastosowania cefiksymu u osób dorosłych chorujących na przewlekłe zapalenie oskrzeli, ostre zapalenie zatok obocznych nosa i w zakażeniu dróg moczowych.
Wildagliptyna – wyjątkowy inhibitor DPP-4
Authors: Dzida Grzegorz
Published: February 2023

Wildagliptyna jest jedynym lekiem z grupy inhibitorów DPP-4, który stosuje się 2 razy dziennie. Chociaż nie przeprowadzono badania poświęconego bezpieczeństwu sercowo-naczyniowemu stosowania tego leku, to licznie opublikowane metaanalizy oraz badania obserwacyjne jednoznacznie potwierdziły bezpieczeństwo wildagliptyny w tym zakresie. Szczególną uwagę zwraca badanie VERIFY, które wykazało, że zastosowanie skojarzonego leczenia metforminą i wildagliptyną od momentu rozpoznania cukrzycy typu 2 zapewnia długotrwałą skuteczność i odkłada w czasie potrzebę wdrożenia insulinoterapii.
Professor Olive Mary Hilliard Burtt (1925–2022)
Authors: Noltie Henry
Published: February 2023

Obituary of Professor Olive Mary Hilliard Burtt.
Gambaran Patologi Anatomi dan Histopatologi Sistem Saraf Itik Bali Pascainfeksi Buatan Avian orthoavulavirus 1 Isolat Tabanan-1/ARP/2017
Authors: Sari Yeni Ratna , Adi Anak Agung Ayu Mirah , Winaya Ida Bagus Oka
Published: February 2023

Penelitian ini dilakukan untuk mengetahui perubahan patologi anatomi dan histopatologi organ cerebrum, cerebellum, medulla spinalis, dan nervus ischiadicus itik bali yang diinfeksi Avian orthoavulavirus 1 isolat Tabanan-1/ARP/2017. Penelitian ini menggunakan 15 ekor itik bali jantan umur 21 hari yang telah diaklimatisasi selama dua minggu. Sepuluh ekor itik perlakuan terinfeksi (P1) diinfeksikan dengan AOAV-1 isolat Tabanan-1/ARP/2017 dengan dosis 0,5 ml/27 HAU secara intraokular, serta 5 ekor itik kontrol (P0), diberikan larutan Phosphate Buffered Saline sebanyak 0,5ml secara intraokular. Itik yang mati kemudian dinekropsi untuk dilakukan pemeriksaan patologi anatomi. Organ saraf diproses dan diwarnai dengan pewarnaan Hematoksilin-Eosin, kemudian dalakukan pemeriksaan histopatologi. Pada pemeriksaan patologi anatomi ditemukan perubahan encephalomalacia pada cerebrum dan cerebellum. Perubahan histopatologi didominasi oleh kongesti, edema perivascular, proliferasi endotel, vakuolisasi neuropil, vaskulitis, dan gliosis pada organ sistem saraf pusat. Sedangkan gambaran histopatologi pada nervus ischiadicus berupa kongesti.
Histopatologi Limpa Ayam Petelur Pascavaksinasi Avian Influenza H5N1 Isolat dari Bali
Authors: Wardani Putu Intan Kusuma , Kencana Gusti Ayu Yuniati , Winaya Ida Bagus Oka , Supartika I Ketut Eli
Published: February 2023

Avian Influenza H5N1 termasuk ke dalam kelompok penyakit menular strategis dan bersifat zoonosis mematikan baik pada hewan maupun manusia yang terinfeksi. Salah satu strategi utama dalam pencegahan AI di Indonesia yaitu dengan vaksinasi. Efektivitas vaksin AI akan lebih baik apabila strain virus dalam vaksin yang digunakan homolog dengan strain virus yang ada di lapangan. Penelitian ini bertujuan untuk mengetahui histopatologi limpa ayam petelur pascavaksinasi AI-H5N1 isolat dari Bali dengan parameter diameter folikel limfoid pulpa putih limpa. Sebanyak 36 ekor ayam petelur strain Novogen Brown digunakan untuk sampel penelitian. Sampel dibagi menjadi 2 kelompok yaitu P0/kelompok kontrol tanpa perlakuan dan P1 kelompok dengan perlakuan vaksinasi AI-H5N1 isolat dari Bali. Masing-masing kelompok terdiri dari 18 ekor ayam petelur. Ayam dipelihara sejak berusia 1 hari. Vaksinasi dilakukan setelah ayam berumur 5 minggu dan di booster pada umur 10 minggu dengan dosis vaksin 0,5 ml/ekor. Pengambilan sampel organ limpa dilakukan tiga minggu pascavaksinasi booster untuk pembuatan preparat histopatologi. Data hasil pemeriksaan preparat histopatologi limpa ayam petelur dianalisis dengan uji-t. Hasil penelitian pengukuran pada organ limpa, menunjukkan rerata diameter folikel limfoid pulpa putih limpa ayam petelur dengan perlakuan vaksinasi AI-H5N1 isolat dari Bali memiliki diameter lebih besar dibandingkan dengan kelompok ayam yang tidak divaksinasi. Simpulan dari penelitian ini adalah vaksinasi AI-H5N1 isolat Bali berpengaruh nyata terhadap penambahan diameter folikel limfoid pulpa putih limpa ayam petelur pascavaksinasi.
Pengaruh Pemberian Berbagai Konsentrasi Asam Butirat terhadap Performa dan Persentase Karkas Ayam Pedaging
Authors: Abel Ribka Natasia , Bebas I Wayan , Sumadi I Ketut
Published: February 2023

Penelitian ini dilakukan untuk mengetahui pengaruh pemberian berbagai konsentrasi asam butirat terhadap performa dan persentase karkas ayam pedaging. Penelitian menggunakan ayam pedaging strain CP 707, PT. Charoen Pokphand dan dilakukan di Desa Penebel, Kecamatan Penebel, Kabupaten Tabanan, Provinsi Bali. Penelitian menggunakan rancangan acak lengkap (RAL) dengan 4 perlakuan dan 6 ulangan. Adapun perlakuannya yaitu P0 (pakan tanpa asam butirat/kontrol), P1 (pakan ditambah asam butirat 0,1%), P2 (pakan ditambah asam butirat 0,2%), dan P3 (pakan ditambah asam butirat 0,3%). Variabel yang diukur meliputi pertambahan berat badan, konsumsi pakan, rasio konversi pakan (FCR), dan persentase karkas ayam pedaging. Data yang diperoleh dianalisis menggunakan Analysis of Variance (ANOVA) dan apabila terdapat perbedaan dilanjutkan dengan Uji Jarak Berganda Duncan. Hasil penelitian menunjukkan bahwa pemberian asam butirat dengan konsentrasi 0,1%, 0,2% dan 0,3% berpengaruh nyata dalam meningkatkan performa ayam pedaging. Pemberian berbagai konsentrasi asam butirat berpengaruh nyata tehadap pertambahan berat badan ayam pedaging, namun tidak berpengaruh nyata terhadap konsumsi pakan dan konversi pakan ayam pedaging. Pemberian asam butirat dengan konsentrasi 0,1%, 0,2% dan 0,3% juga berpengaruh nyata dalam meningkatkan persentase karkas ayam pedaging.
Keragaman dan Korelasi Dimensi Kedalaman dan Tinggi Tubuh Induk Sapi Bali di Pusat Pembibitan Sapi Bali Unggul Gerogak, Buleleng, Bali
Authors: Prama Putra I Gede Bim Shiddi , Sampurna I Putu , Suatha I Ketut
Published: February 2023

Penelitian ini bertujuan untuk mengetahui keragaman dan korelasi antara dimensi kedalaman dan tinggi tubuh induk sapi bali berdasarkan pengukuran dimensi kedalaman dan tinggi induk sapi bali dan dapat dipakai sebagai indikasi dalam melakukan seleksi bibit induk sapi bali pada Pusat Pembibitan Sapi Bali Unggul (PPSBU) di Desa Gerokgak, Buleleng, Bali. Objek penelitian yang digunakan terdiri atas 25 ekor induk Sapi Bali yang berada di PPSBU. Data yang diperoleh kemudian dianalisis dengan analisis deskriptif untuk mencari rata- rata, standar diviiasi, dan koefesien keragaman. Korelasi antara antara dimensi kedalaman dan tinggi tubuh dianalisis dengan analisis biplot. Hasil penelitian yang diperoleh induk sapi bali yang dipelihara di PBSBU Gerogak, Buleleng, Bali mempunyai keragaman yang paling besar (beragam) adalah dalam dada yaitu sebesar 18,1191%, kemudian disusul oleh dalam leher sebesar 17, 5706%, tinggi plank yitu sebesar 16,1236%, dalam kemudi sebesar 11,9739% dan yang paling segaram adalah tinggi tubuh yaitu sebesar 5,3987%.Tinggi tubuh berkorelasi positif dengan dalam leher dan tinggi plank, tetapi tidak berkorelasi dengan dalam dada dan dalam kemudi, sedangkan tinggi plank berkorelasi negatif dengan dalam dada dan dalam kemudi.
Perbedaan Titer Antibodi Newcastle Disease pada Broiler yang Divaksinasi Umur Satu Hari dan Tujuh Hari
Authors: Permatasari Dwi Arum , Suardana Ida Bagus Kade , Nindhia Tjokorda Sari
Published: February 2023

Newcastle Disease (ND) adalah penyakit yang disebabkan oleh avian Paramyxovirus type-1. Gejala umum yang terlihat pada awal infeksi adalah penurunan nafsu makan, lesu dan konjungtivitis. Strategi utama yang dapat dilakukan untuk mencegah munculnya penyakit ND adalah dengan penerapan sistem biosekuriti dan vaksinasi, keberhasilan vaksinasi ditunjang dengan pemeriksaan titer antibodi pascavaksinasi. Penelitian ini bertujuan untuk mengetahui perbandingan titer antibodi Newcastle Disease pada broiler yang divaksin umur satu hari dan tujuh hari. Penelitian ini menggunakan 30 ekor broiler, yang dibagi menjadi tiga kelompok perlakuan yaitu kelompok sampel pertama ayam yang tidak divaksinasi sebagai kontrol (P0), kelompok kedua ayam yang divaksin umur satu hari dipabrik (P1) dan kelompok ketiga ayam yang divaksin umur tujuh hari (P2). Pengambilan sampel darah pada kelompok P0 dilakukan mulai dari umur 7, 14, 21, 28 dan 35 hari, kelompok P1 pada umur 7, 14 dan 21 hari serta pada kelompok P2 pada umur 14, 21 dan 28 hari secara acak (random sampling), melalui vena brachihialis. Pemeriksaan serum titer antibodi dilakukan dengan uji serologis Haemaglutination Inhibition (HI). Data yang diperoleh dari hasil pemeriksaan serologis dianalisis dengan menggunakan uji sidik ragam dan dilanjutkan analisis regresi menggunakan software SPSS. Hasil penelitian menunjukan, terdapat perbedaan titer antibodi ND yang signifikan pada minggu pertama dan kedua pascavaksinasi serta tidak terdapat perbedaan signifikan pada minggu ketiga pascavaksinasi. Perlu dilakukan vaksinasi ulang (booster) pada broiler yang divaksinasi satu hari pada umur 13 hari dan broiler yang divaksinasi umur tujuh hari pada umur 25 hari untuk kembali meningkatkan imunitas.
Analysis The Impact Of Industrial Areas On HIV Aids Incidence
Authors: Masruroh Masruroh , Verawati Bernadeta , Wijayanti Heny Noor
Published: February 2023

Research Background : South Jepara Regency is an industrial area that absorbs a lot of labor around the company's establishment. Over time, the incidence of HIV AIDS has increased. Data from the Jepara health office in Pecangaan District in 2018 reached 48 cases, in Mayong District in 2018 it reached 29 cases and in Kalimatan District in 2018 it reached 21 cases.Research Objective: To analyze the impact of industrial estates on the incidence of HIV AIDS.Research Methods: This type of research is qualitative with in-depth interview data collection techniques. Time of data collection in November 2019. The research location is Pecangaan, Kalinyamatan and Mayong Districts, Jepara Regency, Central Java. The number of research informants is 10 people. Miles and Huberman interactive data analysisThe results of the study: the positive impact of increasing economic welfare and reducing the number of unemployed, while the negative impact of water pollution, the proliferation of hangouts and the construction of many boarding houses.Conclusion: Industrial growth in the southern part of Jepara Regency, has positive and negative impacts. Industrial environmental conditions as an indirect cause of the increasing incidence of HIV AIDS.
The Influence of Support System on the Readiness to Motherhood Transition in Padang Independent Midwive Practice
Authors: Yulizawati Yulizawati , Fitria Henni , Oktova Rafika
Published: February 2023

This study saw the influence of adult attachment style and support systems on the readiness for the transition to motherhood. It is hoped that there will be an optimization of the preparedness for the motherhood transition for women who give birth for the first time. The long-term goal of this study is to assist mothers in optimizing preparation for the transition period to motherhood and obtaining a healthy pregnancy, minimizing the incidence of complications and morbidity in mothers so that it can contribute to reducing the morbidity rate, maternal mortality rate, and infant mortality rate.The specific target of this study is the achievement of psychological well-being in puerperal mothers, which can be obtained from cooperation with their husbands and social support from their environment.This research activity plan aligns with UNAND's National Research Priorities and Development Master Plan. This research is included in one of PRN's research fields in the focus area of health and drug research. This research is also following the RIP of Andalas University, including the central theme of research, namely health, with the sub-theme of nutrition and health, the sub-topic of development.
Narrative Review Encouraging Factors of Mothers to Carry Out Gentle Birth Program
Authors: Savira Vanessa Alivia , Yulizawati Yulizawati , Hardisman Hardisman
Published: February 2023

Childbirth is considered a frightening and painful process for most pregnant women, especially primiparas. This causes pregnant women to choose cesarean delivery. A gentle birth program is an approach to care for pregnancy and childbirth that helps mothers overcome their anxiety in dealing with childbirth. This study aimed to determine the factors that encourage mothers to carry out a gentle birth program.This type of research is a narrative literature review. The research was conducted from October to December 2021. Article searches were accessed through the PubMed, ScienceDirect, and Google Scholar databases. Articles were selected based on inclusion and exclusion criteria.The analysis was carried out on ten research articles. The results of internal factors that encourage mothers to carry out a gentle birth program are the mother's knowledge, mother's interest, mother's motivation, mother's perception, mother's experience of childbirth, mother's psychological aspect, and mother's belief in her abilities. Meanwhile, external factors encouraging mothers to carry out a gentle birth program are the husband's support, support from health workers, family and friends, and health facilities.The mother's knowledge is the dominant internal factor that encourages mothers to carry out a gentle birth program. Meanwhile, the husband's support is the dominant external factor that encourages mothers to carry out a gentle birth program
Acute pneumonitis after subcutaneous injection of BIO-ALCAMID® in breast: Case report
Authors: Villanueva-Villegas Renzo , Trigoso Gutiérrez Anita Yesseña , Castillo-Gutierrez Piero , Salas-López Juan A.
Published: February 2023

Filling materials are used to correct soft tissue deficits. Local and systemic complications are described when these substances are applied. The polyalkylamide gel (Bio-alcamid) used as filler material has been associated with complications at the facial level, while at the pulmonary level they have not been reported in the literature. We present the case of a patient who consulted due to sudden progressive dyspnea hours after the subcutaneous injection of Bio-alcamid in the breasts. After the clinical evaluation and the result of auxiliary tests, the diagnosis of acute pneumonitis secondary to the injection of this substance is concluded. Follow-up of the case was carried out with favorable evolution and resolution of symptoms after three months. We conclude that Bio-alcamid can generate complications at the pulmonary level, therefore, the intervention of public policies that regulate its use, commercialization and application by non-medical personnel is necessary.
Management indicators in research 2022
Authors:   Instituto de Investigaciones en Ciencias Biomédicas, Universidad Ricardo Palma. Lima, Perú., De La Cruz Vargas Jhony A. , Rodríguez Chávez Elio Iván ,   Rectorado, Universidad Ricardo Palma. Lima, Perú.
Published: February 2023

Given the importance of the research component to respond to phenomena and problems demanded by society, At Universidad Ricardo Palma, research has been fostered and promoted as an institutional policy. The Instituto de Investigación en Ciencias Biomédicas, which reports to the Rectorate and is integrated into the Facultad de Medicina Humana, has been working to contribute substantially to this growth in research. The research is directly related to the quality processes of higher education, innovation, extension, linking, licensing, accreditation, and finally, the ranking of universities. As is evident, the research is linked to the present and the future of universities. Therefore, measuring the impact of research is essential because educational institutions are and must be permanent generators of intellectual property, knowledge and human resources, which impact the educational, scientific, economic and social sectors.
Effectiveness of an online course for medicine residents on glycaemic management of hospitalized patients with diabetes
Authors: SHANMUGANATHAN ARUN SARAVANAN , SHAMANNA SURYANARAYANA BETTADPURA
Published: February 2023

Background

Hyperglycaemia and hypoglycaemia in hospitalized patients are associated with poor clinical outcomes. We assessed whether administration of an online educational course for medicine residents improves the glycaemic management of hospitalized patients with diabetes.

Methods

We conducted this quasi-experimental, pre-post study from January 2019 to April 2019. The contents of the course were in compliance with the American Diabetes Association Guidelines 2018. After participating in the online course, the change in the knowledge of residents was assessed by pre- and post-test questionnaire and changes in the inpatient diabetes care were assessed by case record review of the hospitalized patients with diabetes managed by them before and after the participation in the course.

Results

Fifty-six residents participated and completed the online course. Their average post-test scores increased by 11.6%. One hundred and eighteen patients managed by the residents in the same wards before and after the participation in the course were studied. After attending the course, glycaemic targets were predetermined in 75.4% of patients compared to 32.2% before and adequacy of glucose monitoring improved. The total hypoglycaemic event rate reduced significantly by 45.8% and this was accompanied by a trend towards improved glycaemic control. At the time of discharge, the patient awareness on insulin injection technique, hypoglycaemic symptoms and its home remedies were significantly increased.

Conclusion

The administration of an online course increases the knowledge level of residents, improves patient safety and may improve glycaemic control in hospitalized patients with diabetes.
Association between spontaneous intracranial epidural hematoma and craniofacial infections: A systematic literature review
Authors: Scafa Anthony Kevin , Jiang Tingting , Pescatori Lorenzo , Corsini Massimo , Piccirilli Manolo
Published: February 2023

Background:

Spontaneous and nontraumatic epidural hematoma (SEDH) is a rare entity. Etiology is various, including vascular malformations of the dura mater, hemorrhagic tumors, and coagulation defects. The association between SEDH and craniofacial infections is rather unusual.

Methods:

We performed a systematic review of the available literature using the PubMed, Cochrane Library, and Scopus research databases. Literature research was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. We exclusively included studies reporting demographic and clinical data, published until October 31, 2022. We also report one case from our experience.

Results:

A total of 18 scientific publications, corresponding to 19 patients, met the inclusion criteria for the qualitative and quantitative analysis. Patients were mostly adolescents, with a clear male predominance. SEDHs frequently occurred in the frontal area, usually near the site of the infection. Surgical evacuation was the treatment of choice with good postoperative outcomes. Endoscopy of the involved paranasal sinus should be achieved as soon as possible to remove the cause of the SEDH.

Conclusion:

SEDH may occur as a rare and life-threatening complication of craniofacial infections; therefore, prompt recognition and treatment are mandatory.
A simple technique for generating 3D endoscopic images
Authors: Campero Alvaro , Baldoncini Matias , Villalonga Juan F. , Nernekli Kerem , Pipolo Derek Orlando , Forlizzi Valeria , Fernandez-Miranda Juan C.
Published: February 2023

Background:

Most neurosurgical photographs are limited to two-dimensional (2D), in this sense, most teaching and learning of neuroanatomical structures occur without an appreciation of depth. The objective of this article is to describe a simple technique for obtaining right and left 2D endoscopic images with manual angulation of the optic.

Methods:

The implementation of a three-dimensional (3D) endoscopic image technique is reported. We first describe the background and core principles related to the methods employed. Photographs are taken demonstrating the principles and also during an endoscopic endonasal approach, illustrating the technique. Later, we divide our process into two sections containing explanations, illustrations, and descriptions.

Results:

The results of taking a photograph with an endoscope and its assembly to a 3D image has been divided into two parts: Photo acquisition and image processing.

Conclusion:

We conclude that the proposed method is successful in producing 3D endoscopic images.
Foramen magnum meningioma approached by the midline subtonsilar approach – Revisiting Cushing’s classification of craniospinal meningiomas
Authors: da Silveira Roberto Leal , Von Zuben Daniela de Oliveira , Bertani Raphael , Landeiro Jose Alberto
Published: February 2023

Background:

The management of foramen magnum meningiomas (FMMs) has been a challenge for skull base neurosurgeons. Since the initial description of a FMM in 1872, various surgical approaches have been described. Posterior and posterolateral FMMs are safely removed through a standard midline suboccipital approach. Nevertheless, we still face controversy regarding the management of anterior or anterolateral lesions.

Case Description:

A 47-year-old patient presented with progressive headaches, unsteadiness, and tremor. Magnetic resonance imaging showed an FMM that caused significant displacement of the brainstem.

Conclusion:

This operative video highlights a safe and effective surgical technique for the resection of an anterior foramen magnum meningioma.
Assessment of Immunosuppressive Therapy Adherence in Transplantation Patients
Authors: Atay Doyğacı Ayşe Gül , Güler Sevil
Published: February 2023

Introduction: In the post-transplant period, patients should use immunosuppressive drugs regularly and correctly throughout their lives to prevent rejection.
Objectives: This descriptive study was conducted to determine adherence to immunosuppressive therapy in renal, liver and heart transplant patients.
Materials and Methods: The study sample consisted of 60 patients who underwent renal, liver, and heart transplantation and follow-up visits at a foundation university hospital. Data was collected by face-to-face interviews with transplantation patients. The immunosuppressive drugs used by the patients were compared from the hospital records and their compliance with the immunosuppressive treatment plan was determined. Descriptive statistics, Spearman correlation coefficient, Chi-squared, and Fisher Exact tests were used for data evaluation.
Results: In the study, renal transplantation was performed in 46.7% of the patients, liver transplantation in 36.7%, heart transplantation in 13.3%, and simultaneous renal-liver transplantation in 3.3%. All patients received immunosuppressive therapy and therapy adherence rate was 86.7%. A significant positive correlation was found between the total number of immunosuppressive drugs and the number of drugs used in line with the treatment plan (p<0.001). All patients had used immunosuppressive drugs regularly, 40.0% had the factors affecting regular drug use, and the first two factors were as follows: forgetting to use immunosuppressive drugs (70.8%), and inappropriate drug hours (25.0%).
Conclusion: The results showed that the patients should be evaluated regularly in terms of immunosuppressive therapy adherence and nonadherence factors in the post-transplantation period. Programs should be developed.
THE USE OF CRUSHED CHLORITE AT MUNICIPAL SOLID WASTE LANDFILLS
Authors: Шершнева М.В. , Бенза Е.В. , Лагздина А.С.
Published: February 2023

В статье рассмотрена проблема негативного воздействия полигонов твердых коммунальных отходов на окружающую среду. Показано, что спецтранспорт работающий на полигоне или доставляющий туда отходы также вносит свой вклад в негативное воздействие на санитарно-гигиенические условия территории. В работе исследованы биоцидные свойства хлоритового щебня и показаны перспективы его применения в системах обмывки автомобилей при их дезинфекции.

The article deals with the problem of the negative impact of municipal solid waste landfills on the environment. It is shown that special transport operating at the landfill or delivering waste there also contributes to the negative impact on the sanitary and hygienic conditions of the territory. The paper investigates the biocidal properties of crushed chlorite and shows the prospects for its use in car washing systems during their disinfection.
GEO-ECOPROTECTIVE PARAMETERS OF FOAM CONCRETE
Authors: Шершнева М.В. , Лагздина А.С.
Published: February 2023

В статье рассмотрена проблема использования строительных материалов для защиты почв и грунтов от загрязнения нефтепродуктами. Показано, что для создания геоэкозащитных экранов необходимо знать такие параметры пенобетонов, как поглотительная активность, рабочая емкость, кинетика поглощения; удельная величина локализации. Приведены результаты исследования рабочей емкости пенобетонов различных плотностей.

The article considers the problem of using building materials to protect soils and soils from oil pollution. It is shown that in order to create geo-eco-protective screens, it is necessary to know such foam concrete parameters as absorption activity, working capacity, absorption kinetics; specific value of localization. The results of the study of the working capacity of foam concrete of various densities are presented.
STUDY OF PHOTOSYNTHETIC ACTIVITY OF PHYTOPLANKTON IN THE STERLEAGE POND OF ZBS MGU USING CHLOROPHYLL FLUORESCENCE
Authors: Сидоченко Н.Д. , Маторин Д.Н. , Горячев С.Н. , Братковская Л.Б. , Орлова В.С.
Published: February 2023

Изучена фотосинтетическая активность фитопланктона в Стерляжьем пруду Звенигородской станции МГУ. В ходе исследования была установлена связь между физиологическим состоянием фитопланктона и изменения световых условий в водоеме.

The photosynthetic activity of phytoplankton in the Sterlyazhy pond of the Zvenigorod station of the Moscow State University was studied. In the course of the study, a relationship was established between the physiological state of phytoplankton and changes in the light conditions in the reservoir.
PARAMAGNETIC PROPERTIES OF HUMIC ACIDS IN SAPPELS FROM LAKES IN THE SURGUT REGION
Authors: Шпынова Н.В. , Неустроев О.А. , Сартаков М.П. , Барабанщикова Л.Н.
Published: February 2023

Целью данной работы является изучение электронного парамагнитного резонанса гуминовых (ГК) и гиматомелановых кислот (ГМК) донных отложений восьми малых озер, расположенных на правом берегу реки Обь (Западная Сибирь) в Сургутском районе Ханты-Мансийского автономного округа – Югры. Полученные ЭПР спектры говорят о том, что ГК обладают большей парамагнитной активностью, чем ГМК того же образца.

The purpose of this work is to study the electron paramagnetic resonance of humic (HA) and hymatomelanic acids (HMA) bottom sediments of eight small lakes located on the right bank of the Ob River (Western Siberia) in the Surgut region of the Khanty-Mansiysk Autonomous Okrug – Yugra. The obtained EPR spectra indicate that HA have a higher paramagnetic activity than HMA of the same sample. This lies in the greater content of paramagnetic centers per gram in molecules. The results obtained indicate a higher condensed aromatic component in HA compared to HMA.
POLLUTION OF WATER BODIES IN THE PARK KUZMINKI-LYUBLINO
Authors: Журавлев В.А. , Кириллов С.Н.
Published: February 2023

В работе исследованы показатели кислотности, цветности, общей минерализации, содержания гидрокарбонатов, биогенных элементов, хлоридов, фторидов, сульфатов, общего железа, нефтепродуктов и анионных поверхностно-активных веществ в водоемах парка «Кузьминки-Люблино».

Indicators of acidity, color, total mineralization, content of bicarbonates, biogenic elements, chlorides, fluorides, sulfates, total iron, oil products and anionic surfactants in the water facilities of the Kuzminki-Lublino park were studied.
STATE OF AUTONOMIC REGULATION OF THE CARDIOVASCULAR SYSTEM IN PATIENTS WITH PSORIASIS
Authors: Машина М.В. , Нестеров А.С.
Published: February 2023

В настоящее время актуально изучение кардиоваскулярной патологии у больных псориазом. Существуют отдельные исследования, подтверждающие наличие связи между хроническими воспалительными явлениями при псориазе и риском заболевания сердечно-сосудистой системы. Данной проблеме посвящены отдельные исследования вариабельности ритма сердца, эндотелиальной дисфункции у больных псориазом. Установлена взаимосвязь между нарушениями вегетативной (автономной) регуляции сердца, тонуса сосудов и тяжестью псориатического поражения кожи и суставов [1, 2]. Стандартные кардиоваскулярные тесты (КВТ), предложенные D. J. Ewing в 1975г., актуальны для первичного выявления и мониторинга прогрессирования кардиоваскулярной вегетативной нейропатии [3]. С помощью вегетативного индекса Кердо и кардиоваскулярных тестов (КВТ) определялось состояние вегетативной (автономной) функции сердечно-сосудистой системы у больных псориазом. Обследовано 90 стационарных больных вульгарным псориазом (ВП) и псориатическим артритом (ПА). Среди них – 59 мужчин и 31 женщина в возрасте от 20 до 69 лет, средний возраст обследуемых – 46,6 (±13,96) лет. Среди обследованных лиц, вульгарная форма псориаза установлена у 65 больных, псориатический артрит (ПА) – у 25 больных. Вычислялся индекс Кердо, основанный на уровне артериального давления и частоты сердечных сокращений в состоянии относительного покоя. Проведены КВТ, на основанные разнице уровня артериального давления и частоты сердечных сокращений до и после выполнения дыхательной и физической нагрузки.

The relationship between disorders of vegetative (Autonomous) regulation of the heart, vascular tone and the severity of psoriatic lesions of the skin and joints. With the help of vegetative Kerdo index and cardiovascular tests (СT) to determine the state of autonomic function of the cardiovascular system in patients with psoriasis. 90 patients with psoriasis vulgaris (PV) and psoriatic arthritis (PA) were examined. The Kerdo index was calculated based on the level of blood pressure and heart rate at relative rest. Conducted CT, based on the difference in blood pressure and heart rate before and after performing respiratory and physical activity.
Growth Failure due to JAK Inhibition Overcome by Recombinant IGF-I
Authors:   Department of Pediatrics, University of Arkansas for Medical Sciences, USA, MR Hutchison
Published: February 2023

Introduction: Normal linear growth requires an intact GH/IGF-I axis, wherein GH from the pituitary induces the synthesis and release of IGF-I from the hepatocyte followed by IGF-I-mediated chondrocyte division at the growth plate. At the hepatocyte, GH binding to its cognate receptor results in a conformational change in the intracellular portion of the receptor that recruits and activates the tyrosine kinase JAK2. JAK2 then phosphorylates the transcription factor Stat5b which allows it to bind to the IGF-I promotor and increase IGF-I production. JAK kinase inhibitors are used for the treatment of inflammatory disorders such as rheumatoid arthritis, and theoretically would be expected to interfere with linear growth by impairing IGF-I production. We present a case of growth failure due to JAK2 inhibition and successful treatment with recombinant IGF-I therapy.