bluuebunny/crossref_metadata_2025 huggingface dataset:
Drinking water temperatures altered serum metabolomics and fecal microbiome in a mouse model
Authors: Zhao Ziwei , An Yanjun , Li Yanyan
Published: May 2023

The diet temperature could potentially affect health outcomes. Our study designed the experiment using a mouse model to explore the effect of the drinking water temperature on physiological states. The results indicated that the administration of drinking water at two different temperatures (4℃ representing the cold water and 45℃ representing the warm water) did not significantly affect the food/water intake and body weight but altered serum metabolomics and fecal microbiome. Compared to the control (23℃), the administration of cold water and warm water were both found to affect the pyrimidine metabolism, as evidenced by the decreasing in serum metabolites of Uridine, Cytidine, Deoxyuridine, Dihydrothymine. Moreover, cold water altered fatty acid biosynthesis while warm water affected the pentose phosphate pathway (PPP) which was involved in carbohydrate metabolism. Regarding the gut microbiome, cold water and warm water both could increase the gut microbiome richness and diversity, reduce the F/B ratio, and promote the population of Bifidobacterium when compare to the control group. Meanwhile, cold water additionally increased the abundances of Alistipes, Acinetobacter, and Pseudochrobactrum while the warm water administration reduced the richness Alcaligenes, Coprococcus, Planctomyces, and Polaribacter. Our findings demonstrated that both cold and warm drinking water temperatures appear to alter pyrimidine metabolism and exhibit potential health benefits by increasing bacteria richness and diversity of gut microbiome, in particular the beneficial bacteria Bifidobacterium. Additionally, cold water administration was relevant to fatty acid metabolism while warm water could affect carbohydrate metabolism.
Theoretical-Simulation-Experimental Study on the Hybrid Lubrication Performance of Stepped Hydrostatic Thrust Bearing
Authors: Yu Xiaodong , Feng Yanan , Jiang Hui , Gao Weicheng , Shi Guangqiang , Jiao Jianhua , Dai Ruichun , Jia Wentao , Wang Junfeng
Published: May 2023

Based on static pressure support technology, hydrodynamic, statics theory and tribology theory, theoretical derivation, calculation, simulation, and experimental monitoring of the static pressure, dynamic pressure, total pressure, dynamic pressure ratio, and total temperature rise of the lubricating oil film were conducted. The characteristics of stepped hydrostatic thrust bearing clearance oil film hybrid lubrication were obtained for the first time using a combination of theory, simulation, and experiment. It is found that the static pressure and total pressure of the oil film meet the reduction modes of the Fourier yj function and Fourier yz function within the rotating speed of 0r/min-200r/min. Within the load range of 0t-30t, the static pressure and total pressure of the oil film conform to the growth pattern of the Fourier yj function and Fourier yz function with constant term slopes of 10200 and 12150, and intercepts of 127700 and 156700. The theoretical value of oil film dynamic pressure and rotational speed exhibit a linear growth relationship with a slope of 275.2. The simulation value and rotational speed follow the growth law of the Fourier y model and are basically not affected by the size of the load. As the rotational speed increases, the oil film temperature of the rectangle on the outer side of the oil pad presents a concave shape in the circumferential distribution, while the rectangle on the inner side presents a convex shape.
Construction of diversity panels of landrace rice collections in Myanmar
Authors: Yamagata Yoshiyuki , Furuta Tomoyuki , Saw Ohm Mar , Moe Sandar , Win Khin Thanda , Hlaing Moe Moe , Yasui Hideshi , Ashikari Motoyuki , Thein Min San , Yoshimura Atsushi
Published: May 2023

To meet the future demand of the global population, new varieties to adapt to regional climate changes such as salinity, drought, and submergence and new race emergence of pest disease and insects are expected to be developed for plant breeders. To facilitate efficient screening of germplasm and gene exploration on bi-parental cross populations and genome-wide association study (GWAS), the construction of a compact and genetically characterized germplasm platform is necessary in the National gene bank. In this study, genetic relationships of the representative core collections (CC) conserved in the National Seedbank of Myanmar were investigated using the genotyping-by-sequencing approach. It was found that the accessions were classified into the three clusters corresponding so-called japonica, indica, and aroma subpopulations. For efficient germplasm screening and gene exploration by GWAS on the indica landrace germplasm in Myanmar, a compact diversity panel designated “G” consisting of the 249 accessions was assembled, and genome-wide nucleotide variants were collected by the whole genome sequencing. The principal component analysis using genome-wide variants revealed that the selected accessions did not have an apparent population structure, but the first and second principal component scores correlated to the latitude and longitude, suggesting that latitude is the more causal factor of the geographical variation within the Myanmar landrace. When the reference genome of the leading variety in Myanmar was used, the mixed model genome-wide association analysis provided higher -log10(p) scores and detected seven peaks of apiculus pigmentation of spikelet. The five peak associations of the seven fall into the linkage disequllibrium blocks or neighbor blocks containing the isolated genes involved in anthocyanin pigmentation in rice. These results demonstrated that the combination of the landrace GWAS of the National seed banks and reference sequences genetically related to the landrace provide better research environments in characterization and gene exploration.
Identifying potential biomarkers in acute myocardial infarction based on neutrophil extracellular traps associated genes
Authors: Cao Ye , Wang Qing-Feng , Li Bo , Zou Yuan-Lin , Zhang Jian-Cheng
Published: May 2023

Background Acute myocardial infarction (AMI) represents one of the major critical cardiovascular disorders due to its high mortality and morbidity. Neutrophil extracellular traps(NETs) are essential throughout the thrombotic process of AMI. However, genes associated with NETs in AMI have not been fully described.Methods NETs-associated gene candidates were identified by literature review. AMI-associated datasets(GSE66360) were retrieved from Gene Expression Omnibus (GEO) database. Differentially expressed NETs-associated genes were subjected to Gene Ontology (GO) enrichment, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways enrichment analysis. The marker genes were subsequently selected by the least absolute shrinkage and selection operator (LASSO) and support vector machine-recursive feature elimination (SVM-RFE) algorithms and calculated based on the receiver operating characteristic (ROC) curve. To further probe the potential features of these marker genes, single-gene gene set enrichment analysis (GSEA) was performed. To further discuss immune microenvironment modulations, immune infiltration analysis was performed by CIBERSORT algorithms. Accordingly, an mRNA-miRNA-lncRNA network was constructed. Finally, gene expression levels of these marker gene were verified according to an external dataset (GSE66145).Results Forty-five differentially expressed NETs-associated genes were screened out from the GSE66360 dataset, which was closely linked to myeloid leukocyte activation and inflammatory response. FCAR, LILRB2, PDE4B, S100A12, DNASE1, IL1B, IL6, MMP9, and TLR2 were identified as marker genes. The AUC of marker genes was higher than 0.6 and the AUC of the marker genes-based logistic regression model was 0.981. Functional enrichment analysis results suggested that these marker genes might exert consequential effects in AMI through regulating immune responses. CIBERSORT analysis further revealed that the immune microenvironment alterations may be associated with TLR2, S100A12, LILRB2, IL1B, and FCAR. In addition, the ceRNA network demonstrated a complex regulatory interaction.Conclusion Here we identified and validated 9 NETs-associated genes (FCAR, LILRB2, PDE4B, S100A12, DNASE1, IL1B, IL6, MMP9, and TLR2) as novel biomarkers in AMI pathogenesis. These genes may be involved in the onset and development of AMI through NETs formation. Collectively, our findings have provided potential targets for the diagnosis and treatment of AMI.
Modeling the Structural Relationships Between Trauma Experience with Substance Use Tendency, Depression Symptoms, and Suicidal Thoughts in Individuals with Earthquake Trauma Experience: The Mediatory Role of Peritraumatic Dissociation and Experiential Avoidance
Authors: Ahmadi Farshad , Goodarzi Mohammad Ali , Taghavi Mohammad Reza , Imani Mahdi
Published: May 2023

Background: A significant portion of studies are mainly focused on the formation of post-traumatic stress disorder (PTSD) after earthquake trauma. This is while earthquakes are associated with a wide range­ of ­psychological reactions­. In addition, other ­factors play­ a critical role in the formation of a diverse range of mental problems - personal characteristics, the severity of exposure to earthquake, and post-earthquake psychological distress (e.g., dissociation and avoidance). Therefore, This study investigates the relationship between earthquake intensity experience with substance use tendency, depression, and suicidal thoughts with the mediating role of peritraumatic dissociation and experiential avoidance.
Methods: The participants consist of 323 individuals who had experienced an earthquake disaster four years ago. A set of valid and reliable questionnaires­ was administered to the participants. The gathered data were analyzed‌ using structural equation modeling in ‌SPSS Ver. 24 and LISREL Ver. 24.
Results: The results showed that the intensity of the trauma experience is directly and significantly associated with depression symptoms, peritraumatic dissociation, and experiential avoidance. The experience of trauma had a significant­ indirect effect on the tendency to use substance through experimental­ avoidance. This is while the severity of the trauma experience did not directly correlate with substance use and suicidal thoughts. In addition, peritraumatic dissociation did not mediate the relationship between the severity of trauma experience with substance use, depression, and suicidal thoughts.
Conclusions­: It seems ­that both the experience (severity) of earthquake trauma and some reactions by individuals after a trauma experience can contribute to the prediction of some psychological consequences. These findings indicate the significance of experiential avoidance­ in predicting substance use tendencies. Nonetheless, to draw a clearer picture of­ peritraumatic dissociation, future research should ­focus on­ measuring ­this component more precisely and the inclusion of constructs­ that are naturally dissociative­.
Impact of malnutrition on cancer recurrence, colorectal cancer-specific death, and non-colorectal cancer- related death in patients with colorectal cancer who underwent curative surgery
Authors: Nakamura Yuya , Kawase Makoto , Kawabata Yusuke , Kanto Satoshi , Yamaura Tadayoshi , Kinjo Yousuke , Ogo Yasumasa , Kuroda Nobukazu
Published: May 2023

Purpose The impact of malnutrition on colorectal cancer (CRC) recurrence and cause of death remains poorly understood. The present study aimed to examine how malnutrition, as reflected by the Geriatric Nutritional Risk Index (GNRI), is associated with CRC recurrence and cause of death.Methods Subjects were 601 consecutive stage I-III CRC patients who underwent curative surgery between 2011 and 2017. We divided patients into two groups using GNRI 98 as the cut-off and evaluated the relationship of GNRI with overall survival (OS) and recurrence-free survival (RFS). Competing risk analysis was performed to determine prognostic factors of non-CRC-related death. Hazard functions were then used to examine changes in the risk of recurrence and death in each GNRI group over time.Results The low GNRI group predicted significantly worse OS and RFS in multivariable analyses. Moreover, Fine-Gray model regression revealed that the low GNRI group was a significant predictor of non-CRC-related death. Hazard rate of recurrence and death in the low GNRI was approximately double that observed in the high GNRI group over 5 years; meanwhile, the hazard rate for recurrence in the low GNRI group was similar to that in the high GNRI group after 3 years. Meanwhile, the low GNRI group had a higher risk of non-CRC-related death over the course of 5 years.Conclusions While preoperative malnutrition has a strong prognostic impact, its effect over time differs when endpoints are considered separately. These findings provide valuable information regarding healthcare prioritization during CRC survivorship.
Study on the landslide mechanism of the loess slopes induced by rainfall
Authors: Liu Wei , BAI Ruiqiang , SUN Xinran , Liu Yuhang , SU Xing
Published: May 2023

To reveal the landslide mechanism of the loess slope induced by rainfall, we carried out a series of tests for loess under different permeability durations, and studied the influences of rainfall on the permeability coefficient, the soil water characteristic curve, the components, the microstructure, and the shear strength of the loess. Test results show that the total dissolved solids, the sand particles, and the clay particles will decrease, but the silt particles will increase with the permeability duration, it changes the soil original structure and influences the soil water characteristic curve of the loess. And more than 68% permeability coefficients will loss after permeability test. The infiltrated rainwater will increase the effective saturation of the soil, and the shear strength of the soil will decrease with the increasing of effective saturation. The shear strength further decreases with the infiltration time (or rainfall duration). The landslide will initial once the shear strength reduces to the geostatic stress of the soil slope. The shear strength loss of the soils induced by rainfall should be considered during slope stability analysis. This study can help to understand the initiation of loess landslide induced by rainfall.
Failure to rescue as a quality metric in congenital heart surgeries in a high- complexity service provider institution located in a middle-income country
Authors: Cruz Gustavo , Pedroza Santiago , Vélez Juan F. , Largo Jessica , Tejada Juan F. , Mejía Jorge Humberto
Published: May 2023

Background Failure to rescue has been an effective quality metric in congenital heart surgery. Conversely, morbidity and mortality depend greatly on non-modifiable individual factors and have a weak correlation with better-quality performance. We aim to measure the complications, mortality, and risk factors in pediatric patients undergoing congenital heart surgery in a high-complexity institution located in a low-income country and compare it with other institutions that have conducted a similar study.Methods A retrospective observational study was conducted in a high-complexity service provider institution, in Cali, Colombia. All pediatric patients undergoing any congenital heart surgery between 2019 and 2022 were included. The main outcomes evaluated in the study were complication, mortality, and failure to rescue rate. Univariate and multivariate logistic regression analysis was performed with mortality as the outcome variable.Results We evaluated 308 congenital heart surgeries. Regarding the outcomes, 201 (65%) complications occurred, 23 (7.5%) patients died, and the FTR of the entire cohort was 11.4%. The presence of a postoperative complication (OR 14.88, CI 3.06-268.37, p = 0.009), age (OR 0.79, CI 0.57–0.96, p = 0.068), and urgent/emergent surgery (OR 8.14, CI 2.97–28.66, p < 0.001) were the most significant variables in predicting mortality.Conclusions Failure to rescue is an effective and comparable quality measure in healthcare institutions and is the major contributor to postoperative mortality in congenital heart surgeries. Despite our higher mortality and complication rate, we obtained a comparable failure to rescue rate to high-income countries' health institutions.
Selfing revealed positive values than backcrossing for yield and yield enhancing traits among tomato segregating populations generated from Solanum lycopersicum × S. pimpinellifolium crosses under tropical humid climate
Authors: Ene Chikezie Onuora , Abtew Wosene Gebreselassie , Oselebe Happiness Ogba , Chukwudi Uchechukwu Paschal , Okechukwu Emeka Chibuzor , Ozi Friday Ugadu , Ene Chibueze Kelechi , Menamo Temesgen Matiwos , Atugwu Agatha Ifeoma
Published: May 2023

The objectives of this study were to assess phenotypic variability among F3 and BC1F2 tomato populations, and apply genotype by yield*trait (GYT) biplots for population and line selection based on multiple traits. Four diverse cultivated parents (‘CLN2498D’ and ‘CLN2417H’ from Ethiopia; ‘UC Dan INDIA’ and ‘Tima’ from Nigeria), and wild parent ‘LA2093’ were used to generate 276 potential breeding lines. The lines were categorized into eight populations (‘Pop_1_W/H1’, ‘Pop_2_W/H2’, ‘Pop_3_W/D1’, ‘Pop_4_W/D2’, ‘Pop_5_W/T1’, ‘Pop_6_W/T2’, ‘Pop_7_W/U1’, and ‘Pop_8_W/U2’), and evaluated twice in the field using 19 × 15 alpha-lattice design with two replicates. Significant differences were observed among lines and populations for all yield enhancing traits. ‘Pop_1_W/H1’, ‘pop_4_W/D2’ and ‘pop_6_W/T2’ expressed the highest genetic divergence for plant height, number of leaves, total flower and fruit number, and fruit weight. GYT biplots revealed that all yield*trait interactions had a positive correlation with each other. F3 populations, ‘Pop_5_W/T1’ and ‘pop_1_W/H1’ exhibited the best performance for majority of the yield*trait combinations. Hierarchical clustering on principal components (HCPC) revealed overlapping lines (70.58% of Cluster D lines) and (54.05% of Cluster U lines) from the two F3 populations. In BC1F2 population, 32.35% of the 34 original lines of Cluster D and 48.48% of Cluster T lines overlapped between Clusters D and T, while 18.18% of Cluster T lines and 8.82% of Cluster H lines were transgressive between Clusters T and H. Transgressive segregants ‘0210U1’, ‘0211U1’, and ‘0171T1’ of selfed population using multivariate analysis were believed to represent potential sources of novel genetic variation for future tomato breeding.
Enhancing C. reinhardtii growth and metabolite biosynthesis using organic dyes as spectral convertors
Authors: Ramanna Luveshan , Nasr Mahmoud , Rawat Ismail , Bux Faizal
Published: May 2023

The commercial success of microalgal systems has to a large extent been restricted due to limited light availability and utilisation. Algae utilize the blue and red spectral regions, large amounts of the incoming light energy fall outside this region and remain unused. The spectral conversion of unusable to usable wavelengths will increase the amount of radiation available for photosynthesis. This study was conducted to determine the optimum organic dye among Lumogen Red (LR), Rhodamine 8G (R8G), and Lumogen Yellow (LY) as spectral converters, providing the best light utilisation efficiency in an algal system. The microalga Chlamydomonas reinhardtii was cultivated in double-jacketed cylindrical photo-bioreactors (PBRs) stimulated using 30% UV-a and 5% UV-b fluorescent tubes. Carbohydrate and lipid contents were produced early in the growth phase, whereas biomass and protein content increased after day 4. The LR dye maintained better photo-stability compared to R8G and LY, which displayed a slight wavelength shift and photo-degradation, respectively. The improved biomass production in the LR-assisted PBR was illustrated by increased Y(II), with decreasing Y(NPQ), total chlorophylls, and carotenoids. Pigment biosynthesis was initially increased and then reduced to compensate for the increased irradiation as a means of photoprotection. Gene expression studies showed that algae grown under LR had a 1.6- and 2.9-fold up-regulation of the RuBisCo gene. The applicability of the dye-based algal system was linked to enhanced growth, lipid, protein, carbohydrate, and pigment productions. Moreover, the environmental, economic, and social aspects of improving microalgal cultivation using dye-based wavelength conversion systems were interlinked to the sustainable development goals.
"There is no one who helps you with it." Experiences of people with long COVID regarding medical care, therapeutic measures, and barriers in the German healthcare system: results of a qualitative study with four focus groups
Authors: Schmachtenberg Tim , Königs Gloria , Dragaqina Anita , Roder Sascha , Müller Frank , Müllenmeister Christina , Schröder Dominik , Dopfer-Jablonka Alexandra , Vieth Katharina , El-Sayed Iman
Published: May 2023

Background
Many people experience long-term symptoms such as fatigue, cognitive problems, or shortness of breath after an acute infection with COVID-19. This emerging syndrome, known as long COVID, is new and complex in many aspects. This study aims to collect the experiences of people with long COVID with ambulatory healthcare structures.
Methods
Four focus groups were conducted with a total of 23 adults with long COVID in June and July 2022. These discussions were audio-recorded, subsequently transcribed, and analyzed using the qualitative content analysis of Mayring and Kuckartz.
Results
Fourteen out of 19 participants who had a primary care encounter regarding their long COVID symptoms did not perceive it as helpful. Many respondents reported that their general practitioners did not take their long COVID symptoms seriously and did not refer them to specialists or made therapeutic recommendations. However, some participants reported that they were prescribed non-pharmaceutical therapies (e.g., group meetings supported by psychotherapists, occupational therapy, etc.) that improved their condition. 14 of 23 respondentsperceived care barriers such as providers' lack of awareness of long COVID, poor access to specialists, a lack of specialized care (e.g., long COVID clinics), or high bureaucratic hurdles for specific healthcare services. To improve medical care, participants suggested campaigns to raise awareness of long COVID among healthcare providers and the general population, increase research and government investments regarding the development of treatment structures for long COVID, expanding existing therapeutic services, and establishing one-stop shops for integrated specialist healthcare for people with long COVID.
Conclusions
Several implications for healthcare professionals and policymakers can be derived from this study: (1) general practitioners should take the symptoms of long COVID seriously, assume a care coordinating role, make referrals, and establish contact with long COVID clinics; (2) care planners should focus on developing interprofessional evidence-based care and treatment approaches for long COVID; (3) existing care structures such as long COVID outpatient clinics should be expanded.
Trial registration: The study is registered in the German register for clinical trials (DRKS00026007).
The Influence of Academic Stress on College Students' Learning Motivation: The Mediating Role of Academic Environment Satisfaction and the Moderating Role of Learning Adaptability
Authors: Liu Chen , Tang Jiayi , Jiang Zhou , Zhan Xingya , Shen Junjie , Wang Mengying , Shen Chao , Liu Xin
Published: May 2023

The relationships between academic stress, learning motivation, academic environment satisfaction, and learning adaptability were examined in a group of undergraduate students in Jiangsu Province, China. The survey was completed by 1666 students, with 1607 students whose questionnaire was complete and valid. College students' learning motivation was positively correlated with their academic stress (r = 0.218, P < 0.01), academic environment satisfaction (r = 0.028, P < 0.01), and learning adaptability (r = 0.108, P < 0.01). Academic environment satisfaction mediated the relationship between academic stress and learning motivation. Learning adaptability moderated the first half of the path of "academic stress → academic environment satisfaction → learning motivation". In particular, academic stress was a stronger predictor of academic environment satisfaction in the low level of learning adaptability. Thus, in order to enhance learning motivation, we can achieve students' satisfaction by changing the academic environment. In addition, adjusting learning adaptability is also an important way to improve learning motivation through academic environment satisfaction.
Propofol reversibly attenuates short-range microstate ordering and 20 Hz microstate oscillations
Authors: Hermann Gesine , Tödt Inken , Tagliazucchi Enzo , Todtenhaupt Inga Karin , Laufs Helmut , von Wegner Frederic
Published: May 2023

Microstate sequences summarize the changing voltage patterns measured by electroencephalography (EEG), using a clustering approach to reduce the high dimensionality of the underlying data. A common approach is to restrict the pattern matching step to local maxima of the global field power (GFP) and to interpolate the microstate fit in between. In this study, we investigate how the anesthetic propofol affects microstate sequence periodicity and predictability, and how these metrics are changed by interpolation. We performed two frequency analyses on microstate sequences, one based on time-lagged mutual information, the other based on Fourier transform methodology, and quantified the effects of interpolation. Resting-state microstate sequences had a 20 Hz frequency peak related to dominant 10 Hz (alpha) rhythms, and the Fourier approach demonstrated that all five microstate classes followed this frequency. The 20 Hz periodicity was reversibly attenuated under moderate propofol sedation, as shown by mutual information and Fourier analysis. Characteristic microstate frequencies could only be observed in non-interpolated microstate sequences and were masked by smoothing effects of interpolation. Information-theoretic analysis revealed faster microstate dynamics and larger entropy rates under propofol, whereas Shannon entropy did not change significantly. In moderate sedation, active information storage decreased for non-interpolated sequences. Signatures of non-equilibrium dynamics were observed in non-interpolated sequences only and decreased in moderate sedation. All changes occurred while subjects were able to perform an auditory perception task. In summary, we show that low-dose propofol reversibly increases the randomness of microstate sequences and attenuates microstate oscillations without correlation to cognitive task performance. Microstate dynamics between GFP peaks reflect physiological processes that are not accessible in interpolated sequences.
Effect of microalgae diets on growth, proximate and fatty acid composition of black mussel (Mytilus galloprovincialis)
Authors: Pınarbaşı Zeynep Sena , Sayar Merve , Türk Sare Sena , Tınkır Merve , Eryalçın Kamil Mert
Published: May 2023

The aim of this study was to evalute the growth, proximate and fatty acid composition of Black mussel (Mytilus galloprovincialis), which are common bivalve species that important for marine aquaculture in last two decades. Nutritional value and growth dynamics are essential for larval and juvenile stages of cultured animals. In this study, four fresh microalgae (Pavlova lutheri, Nannochloropsis oculata, Diacronema vlkianum and Rhinomonas reticulata) have been studied. Mussels collected from the Marmara Sea were adapted to experimental conditions for 2 days and fed for 3 weeks. Shell height, lenght and witdh of mussels were measured. The height and length of mussels fed with Nanochloropsis oculata measured statistically higher than other experimental groups. Shell widths did not show any significant differences among groups. The proximate analysis revealed that Nanochloropsis oculata has the highest protein content and Pavlova lutheri has the highest lipid content. Fatty acid compositions were analyzed at the end of the experiment. Diacronema vlkianum diet revealed the highest docosahexaenoic acid (DHA) content. Black mussel fed Pavlova lutheri diet showed the highest eicosapentaenoic acid (EPA) and polyunsaturated fatty acid (PUFA) content. Arachidonic acid (ARA) ratios appeared to be similar among mussels fed with all groups.
Impact of Static Magnetic Field on In Ovo Angiogenesis and In Vitro Cell Migration
Authors: Dini Jagath Jayakumar , Purayil Kiran Santh Puthiya , Parsanathan Rajesh
Published: May 2023

Static magnetic field (SMF) therapy has been proven effective in various tissue repairs. Diamagnetic anisotropy may induce SMF to impact biological macromolecules. The formation of new blood vessels, or angiogenesis, is essential for many pathophysiological processes, including development, reproduction, tumour growth, and metastasis. Inhibiting angiogenesis is one of the key objectives in the fight against cancer and other diseases. The mechanism underlying SMF-mediated regulation of angiogenesis and fibroblast migration is still unclear. Thus, the goal is to investigate the influence of SMF on avian angiogenesis using the chorioallantois membrane (CAM) experiment and murine fibroblast migration. Gallus gallus fertilised eggs were placed in an incubator from day 3 to 7 to the isocentre of the Neodymium Magnet block (30 milli Tesla (mT); North-pole or upward; SMF+) was exposed, and control eggs were placed in a separate incubator (SMF-). On day 7, the angiogenesis or neovascularisation vascular parameters were analysed using a stereoscope and AngioTool. SMF+ stimulation showed a statistically significant decrease in vascular parameters compared to the control. Additionally, the effect of SMF+ on murine fibroblast cell viability, ROS, and migration was explored. Compared to unexposed cells, SMF+ stimulation showed a statistically significant decrease in cellular ROS production and migration after 24 hours without a change in cell viability. These findings imply that SMF could be an effective adjuvant therapy for limiting or preventing excessive ROS, angiogenesis, and fibroblast migration; this effect may be utilised to treat cancer, diabetic retinopathy, and other disorders that entail excessive pathological angiogenesis.
An Efficient Early Diagnosis and Healthcare Monitoring System for Mental Disorder using Machine learning Approach
Authors: Reddy C Kishor Kumar , Satvika Pullisani
Published: May 2023

Recently, the increase in internal health problems in society has led to an increase in research on the development of mechanistic capacity models to detect or predict internal mental health. The effective use of internal health assessments or discovery models allows internal health interpreters to redefine internal suffering more objectively than ever before, and in the early stages when interventions may be more effective.In this work, we aim to apply a bias mitigation system based on multitasking literacy to perform a fairness analysis and to fear the predicted model using the Reddit dataset. This article employs an efficient technique for machine learning random forests. The proposed model was evaluated against various performance metrics and the model showed 91.00% accuracy. This is an advantage compared to existing approaches.
Prediction of Skull Fractures in Blunt Force Head Traumas using Finite Element Head Models
Authors: Lindgren Natalia , Henningsen Mikkel J. , Jocobsen Christina , Villa Chiara , Kleiven Svein , Li Xiaogai
Published: May 2023

Traumatic head injuries remain a leading cause of death and disability worldwide. Although skull fractures are one of the most common head injuries, the fundamental mechanics of cranial bone and its impact tolerance is still uncertain. In the present study, a strain-rate-dependent material model for cranial bone has been proposed and implemented in subject-specific FE head models in order to predict skull fractures in five real-world fall accidents. The subject-specific head models were developed following an established image-registration-based personalization pipeline. Head impact boundary conditions were derived from accident reconstructions using personalized human body models. The simulated fracture lines were compared to those visible in post-mortem CT scans of each subject. In result, the FE models did accurately predict the actual occurrence and extent of skull fractures in all cases. In at least four out of five cases, fracture patterns were predicted in agreement with CT scans and autopsy reports. The material model reproduced the mechanical response of cortical bone in tension, while correctly capturing failure mechanisms in blunt indentation loading of a skullcap specimen. The FE model showed to be sensitive to modelling parameters, in particular to the constitutive parameters of the cortical tables.Nevertheless, this study provides a currently lacking strain-rate dependent material model of cranial bone that has the capacity to accurately predict linear fracture patterns. For the first time, a procedure to reconstruct occurrences of skull fractures using computational engineering techniques, capturing the all-in-all fracture initiation, propagation and final pattern, is presented.
Effectiveness of lotilaner on furuncular myiasis in dogs naturally infested with Dermatobia hominis (Diptera: Cuterebridae)
Authors: Tortoriello Rafaella , Christ Luisa Xavier , Manier Bruna Sampaio Martins Land , Fernandes Julio I.
Published: May 2023

Background This study aimed to evaluate lotilaner (Credeli®)’s larvicidal efficacy in the treatment of dogs naturally infested with Dermatobia hominis larvae.Methods A total of 12 dogs that naturally presented at least three live D. hominis larvae were medicated. All the animals could not have undergone any type of insecticide or acaricide and/or larvicidal treatment in a period before 90 days, as an inclusion criterion. The animals were medicated with a single dose of at least 20 mg/kg lotilaner in the oral formulation, following the recommendations in the package insert for other ectoparasitic treatments. After drug administration, the animals remained at their homes, and observations were made to verify the larvicidal effect 6 h after treatment, in addition to possible adverse effects on the medicated animals. Live larvae were considered as any parasite that showed motility after removal. The effect was calculated for each animal using the formula: [100 × (number of live larvae before treatment − number of live larvae after treatment/number of live larvae before treatment)] as criteria for evaluating lotilaner efficacy.Results A total of 98 larvae were counted in 12 dogs, with an average of 8.1 larvae per animal. The majority of the parasites, that is, 38 larvae, were found in the animals’ dorsal region. Lotilaner’s effectiveness was 80.6%. No animal showed adverse effects or changes in behavior after isoxazoline use. Nineteen larvae were found alive, presenting hypomobility and lethargic behavior. Notably, the evaluation only lasted for 6 h.Conclusion Lotilaner, when orally administered in a single dose of 20 mg/kg, is effective in the treatment of dogs naturally infested by D. hominis.
Multi-Modal Imaging-Based Feature Fusion for Accurate Glaucoma Diagnosis with Deep Learning
Authors: Krishna Nanditha , Nagamani K
Published: May 2023

Glaucoma, a leading cause of irreversible blindness worldwide, affects over 76 million people currently and is projected to increase to 111.8 million by 2040 according to the World Health Organization. Glaucoma is often asymptomatic and progresses gradually, making early detection and treatment crucial to prevent irreversible vision loss. Ophthalmologists commonly use eye analysis machines such as ophthalmoscopy and fundus photography to obtain scans for accurate diagnosis and treatment of glaucoma. However, clinical-decision support techniques in medical imaging face challenges in interpretability and reliability. To overcome these challenges and accurately detect glaucoma, this study presents a novel Fire Hawk Optimized Deep Learning Based Retinal Disease Grading and Classification (FHODLB-RDGC) utilizing multi-modal feature fusion from Optical Coherence Tomography (OCT) and Fundus images. Radiomics features for OCT images using DL Technique and cup-to-disc ratio for fundus images using NestNet model are extracted using Deep Learning (DL) techniques and merged. The proposed FHODLB-RDGC technique is of great interest in the field of ophthalmology and has demonstrated enhanced retinal disease classification results in extensive simulations on a benchmark database, particularly in accurately diagnosing glaucoma. Therefore, glaucoma, a severe and potentially blinding retinal disease, has the potential of being more accurately recognised and treated early on owing to the FHODLB-RDGC technique.
The role of diminutive suffixes in the Italian Time Nouns constructions: From approximation to focus?
Authors: Voghera Miriam
Published: May 2023

The time nouns (TNs), minuto (‘minute’), momento (‘moment’), attimo (‘instant’) can be part of constructions in which they keep all their categorial and syntactic properties, but also in constructions which seem to undergo a process of grammaticalisation: loss of categorial property of nominal inflection; the sequence DET+TN (un attimo, un momento, un minuto) can no longer be interrupted by modifiers nor have postnominal modifiers; semantic shift from the original temporal meaning to the more general meaning of a ‘(small) indefinite amount’, to continue towards more properly grammatical values of quantifiers to pragmatic values of hedges, alerter and textual marker of focus. Interestingly, while the original temporal constructions do not occur in diminutive forms, the departure from temporal meaning makes the use of diminutive forms possible. The article explores in which cases they are allowed and the semantic and textual factors which contribute to their presence.
Pengaruh Word Of Mouth, Kualitas Pelayanan, Media Sosial, Store Atmosphere, Fasilitas, Dan Harga Terhadap Loyalitas Pelanggan Pada Warkop Kidol Lepen Tulungagung
Authors: Munandar Aris , Erdkhadifa Rendra
Published: May 2023

The purpose of this study is to identify how word-of-mouth, service quality, social media, store atmosphere, facilities, and prices affect customer loyalty. This research uses primary data obtained from questionnaire responses distributed to customers of Warkop Kidol Lepen, Sumbergempol District, Tulungagung Regency. Warkop Kidol Lepen customers who have purchased at least 2 times as part of this research population. This research uses the Accidental Sampling type of the Non-Probability Sampling method. The sample used was 96 respondents. Validity and reliability tests, multicollinearity tests, coefficient of determination tests, stealth tests (f), partial tests (t), and classic assumption tests such as normality, autocorrelation, and heteroscedasticity tests are used to obtain and analyze data. The findings show that the variables of service quality, store atmosphere, facilities, and price have an impact on customer loyalty, whereas word of mouth and social media do not affect customer loyalty.
A tail of eternal inflation
Authors: Cohen Timothy , Green Daniel , Premkumar Akhil
Published: May 2023

Non-trivial inflaton self-interactions can yield calculable signatures of primordial non-Gaussianity that are measurable in cosmic surveys. We calculate the non-Gaussian corrections to Stochastic Inflation within the framework of Soft de Sitter Effective Theory, from which we derive the associated probability distribution for the scalar fluctuations. As a consequence of this new result, we show that the phase transition to slow-roll eternal inflation is often incalculable in these models. Instead, this transition is sensitive to the non-Gaussian tail of the distribution of scalar fluctuations, which probes physics inside the horizon, potentially beyond the cutoff scale of the Effective Field Theory of Inflation. We delineate the parameter space consistent with current observations and weak coupling at horizon crossing in which the large fluctuations relevant for eternal inflation can only be determined by appealing to a UV completion. We also argue that this breakdown of the perturbative description is required for the de Sitter entropy to reflect the number of de Sitter microstates.
LA CONSULTATION PRECONCEPTIONNELLE: POUR UNE GROSSESSE MEILLEURE
Authors: Zineb Kabba , Aicha Driouch , Fatima Ezzahra Houjjaj Dina Azraq , Hassan Alami Mohamed , Adib Abdelhai Filali , Zakia Tazi Mokha , Bezad Rachid
Published: May 2023

Le suivi de la grossesse a pour objectif dÂ’identifi er dÂ’eventuelles situations Ã risque et dÂ’eviter ou de reduire la morbidite materno-fÂœtale. Cependant, le devenir dÂ’une grossesse pourrait Ãªtre ameliore encore plus si lÂ’on pouvait intervenir avant la grossesse. Cette anticipation permet de prendre en consideration, pour toute femme desireuse dÂ’une grossesse ses antecedents personnels et familiaux, lÂ’examen physique, les resultats biologiques, les vaccinations, les supplementations alimentaires, les adaptations de prise en charge de pathologies et de traitements en cours. Pourtant, la consultation preconceptionnelle reste encore peu pratiquee et mal connue malgre ses benefi ces en termes de coÃ»ts de sante publique et en termes de reduction de la morbidite maternelle et neonatale.
THE CHANGING PARADIGM OF COHABITATION: INTERPLAY BETWEEN SOCIAL NORMS, EMOTIONAL INTERDEPENDENCE AND SUBJECTIVE WELL BEING
Authors:   Department of Psychology, Christ (Deemed to be University) Delhi NCR, India., Jain Deepika , C. Priyesh ,   Assistant Professor, Department of Psychology, Christ (Deemed to be University) Delhi NCR, India.
Published: May 2023

Objectives: The present study attempts to understand how the social norms concerning the idea of cohabitation and different patterns of emotional interdependence affect an individuals subjective well-being in cohabiting relationships. Method: Semi-structured interviews were conducted with 6 participants (three males and three females) aged 21-48 (n=6) in a cohabiting relationship for more than eight months and residing in Indian metropolitan cities. A semi-structured interview schedule with twenty-six questions was designed and validated by three experts. Results: A review of audio recordings, transcripts, and process notes revealed thirteen sub-themes listed under six global themes that emerged from the qualitative analysis: Emotional Covariation Interpersonal Emotion Dynamic Societys Standpoint Social Support Individual Perspective, and Well Being. Conclusion: Examining emotional interdependence, social norms, and subjective well-being, we drew attention to several vital factors of interpersonal emotion dynamics and individual versus relational well-being. Participants views about cohabitation were recorded. A low social acceptance of cohabitation led to significant distress and feelings of anxiety, fear, and uncertainty. The role of social support in higher levels of affective well-being is also analyzed.
A STUDY OFSOCIODEMOGRAPHIC, CULTURAL, ECONOMIC AND PSYCHOLOGICAL CHARACTERISTICSASSOCIATED WITHADOLESCENT PREGNANCYFROM TEA GARDEN COMMUNITY OF SIVASAGAR, ASSAM:CROSS-SECTIONAL SURVEY
Authors:   Research Scholar, Indian Institute of Public Health, Shillong, Meghalaya- 793001., Sagar Dehingia Priyangshu , Priyanka Gogoi Angela ,   NETES Institute of Technology & Science, NEMCARE Group of Institutions, Mirza, Guwahati, Assam-781125
Published: May 2023

Introduction: The World Health Organization (W.H.O), defines adolescence as the period of life between 10 to 19 years (1). Early marriage a hidden, yet known practice in several regions of the world has been a major public health threat where the girl experiences number of health, social, economic, and emotional problems in the form of adolescent pregnancy, synonymously termed teenage pregnancy. Methodology: A descriptive community-based cross-sectional study was conducted in a tea garden community of Sivsagar district from February 2020 to May 2020. Sample size was estimated at 282. Data was collected using pre-designed and pre-tested questionnaire. Variables like socio-demographic characteristics, income of the participant and family members, family size and school drop-out reason were analysed using descriptive statistics. Results and Discussion: In the present study, out of total of 330 eligible participants selected randomly from 12 Tea estates of Sivasagar district, 15.45 % of them were under the age group of 11-16 years and 84.55% belonged from 17-19 years. 82 % were from Other Backward Class, while rest only 18 %. The mental health status shows that out of 330 participants, 41, 91 and 8 had Ã‚Â“extremely severeÃ‚Â” signs of depression, anxiety and stress respectively. Conclusion: This study reflects adolescent pregnancy as a threat to society and demands a thorough exploration. Despite government schemes and legislations, it continues to be prevalent in community.
CAUDAL BLOCK AS A TREATMENT MODALITY TO AVOID LUMBAR SPINE SURGERY IN PATIENTS WITH CHRONIC BACK PAIN
Authors: Pandey K.K. , Vidyarthi Ashok , Johari Vaidant
Published: May 2023

Introduction: Chronic Lower back pain is the most common cause of functional disability in an adult due to prolonged sitting, ageing society, obesity & sedentary lifestyle, the number of Chronic Lower back pain patients can be expected to increase in the coming decades. Caudal Pain Block is one of the procedures to avoid lumbar spine surgery in patients with chronic low back pain. Main aim of this study is to analyse weather the effect of caudal pain block can avoid lumbar spinal surgery in patients with chronic low back pain. Aims And Objectives: To find out that weather the effect of caudal pain block can avoid lumbar spinal surgery in patients with chronic low back pain.To review the literature. Material and Methods: A prospective study was done on 55 patients with chronic low back pain who were given caudal pain block and followed up at 1,2, 3, and 6 months and outcomes measured using visual analogue scale and The Rolandâ€“Morris Disability Questionnaire. Observations: Caudal pain block was given in 55 patients, 51 patients got relieved of their pain and were able to avoid spine surgery and 4 out of 55 patients went for the spine surgery despite given caudal pain block. Results:According to VAS score 12 patients had excellent results, 21 had good results, 18 had fair and 4 had poor results. According to Rolandâ€“Morris Disability Questionnaire - 10 patients had excellent results, 20 patients had good results, 21 had fair results and 4 had poor results. Conclusion:Chronic low back pain managed with Caudal pain block is a good treatment modality with excellent results and good alternative to avoid operative procedures.