bluuebunny/crossref_metadata_2025 huggingface dataset:
«Маленькая Япония»: влияние наследия эпохи Карафуто на туристский образ Южно-Сахалинска
Authors: Зверева Анна-Арина Андреевна
Published: June 2024

В работе представлено исследование туристского образа Южно-Сахалинска, в качестве «стержневого» представления рассматривался ассоциативный образ «Маленькой Японии». Разработана авторская комплексная методология исследования туристско-географической характеристики территории Яжно-Сахалинска, опираюȞаяся на качественные методы исследования: традиционный анализ документов, глубинные интервью и ментальное картографирование, включая образно-географическое картографирование. На основе собранной обȝирной информационной базы составлена сетевая конструкция из узловых объектов — туристская образно-географическая карта Яжно-Сахалинска. Демонстрируется типология туристских образов Южно-Сахалинска: «Первозданный Яжно-Сахалинск», «Азиатский плавильный котел», включая образ «Маленькой Японии», а также «Типичная Россия». Выявлено исключительное влияние ассициативного образа «Маленькой Японии» на формирование туристского образа Южно-Сахалинска как пространственно-связующего и центрового элемента. Наличие объектов Карафуто, на которые есть запрос со стороны туристов, предопределило появление в Южно-Сахалинске современных объектов, представляющих «японскую идентичность» в городе, благодаря чему создается основа для формирования и закрепления в сознании туристов образа Южно-Сахалинска как «Маленькой Японии», который обладает большим потенциалом для развития города в качестве нового узнаваемого бренда и привлекательной туристской дестинации.
Влияние кризиса пандемии Сovid-19 на социально-экономическое развитие моногородов России
Authors: Иванов Илья Романович
Published: June 2024

На сегодняшний день в Российской Федерации насчитывается 321 моногород, в которых суммарно проживает 12,7 млн человек, или 8,7% всего населения России. Моногорода представляют из себя территории, характеризующиеся высокой зависимостью социально-экономической стабильности от одного градообразующего предприятия или отрасли, что и без наличия внешних шоков позволяет относить их к кризисным.
Настоящее исследование посвящено изучению последствий кризиса COVID-19 в моногородах Российской Федерации. В работе изучается, как пандемия повлияла на существующие проблемы, вызванные монопрофильной специализацией; упор сделан на экономические и демографические показатели. В основу легли открытые данные официальной статистики. Для их агрегирования и анализа было написано программное обеспечение, при помощи которого удалось собрать единую базу данных статистических показателей для всей совокупности монопрофильных муниципалитетов с 2015 по 2020 год включительно. Впоследствии путем моделирования с применением метода экспоненциального сглаживания и использованием исторического ряда данных за 5 лет, предшествовавших кризису, были получены прогнозные оценки показателей на 2020 год, как если бы кризиса не произошло, и территории продолжили заданную в прошлые годы тенденцию развития. Задачей работы стал поиск и анализ отклонений между фактическими значениями показателей и их прогнозными оценками, полученными в ходе моделирования. Выявлены негативные отклонения в динамике развития большинства моногородов, но однозначной реакции показателей всех территорий на кризисные условия выявлено не было. Однако проведенная дополнительно стандартизация показателей позволила провести дифференциацию этих территорий и увидеть ряд закономерностей в зависимости от масштаба, отраслевой специализации и пространственного положения моногородов.
Effect of solutionizing heat treatment on the structure and mechanical properties of silicon bronze (Cu-10wt%Si-2wt%Ni)
Authors: Ukamaka E Ezeobi , Chidume N Nwambu , Eugene E Nnuka , Bala M Bosan
Published: June 2024

The effect of solutionizing temperature, soaking time, and quenching media on the structure and mechanical properties of silicon bronze (Cu-10wt%Si-2wt%Ni) has been examined. The samples were produced using the sand casting technique, machined to the required dimensions, and solutionized at temperatures of 700 oC, 800 oC, and 900 oC for 0.5, 1.5, 2.5, and 3.5 hrs and quenched in brine and oil respectively. The prepared as-cast and solution heat-treated samples were subjected to mechanical tests (hardness, and impact strength tests) as well as microstructural analysis. The results of the microstructural analysis revealed the presence of coarse grains and coarse sparse distribution of Ni2Si precipitate in the as-cast sample while the surface morphology of the heat-treated samples consisted of fine grains of intermetallic compounds evenly dispersed in the copper matrix. It was also observed that the microstructures of samples solutionized at lower temperatures (700 oC) revealed finer grains with better grain distributions compared with samples solutionized at higher temperatures (800 oC and 900 oC). These microstructural changes led to the improvement of the hardness and impact strength of the alloy. The hardness value of the as-cast sample 48.5 HRB, increased to 53.7 HRB and 57.8 HRB after solid solution heat treatment at 700 oC for 3.5 h and cooled in brine and oil, respectively. It was also observed that the hardness of the brine-cooled samples increased further to 72.45 HRB after 3.5 h at 900 oC. The results obtained also showed that the solid solution heat-treated samples gave an optimum impact strength value of 214 J/m3 and 183 J/m3 from the samples solutionized at 900 oC and 800 oC for 3.5 h and 1.5 h and cooled in brine and oil respectively. This was concluded to be a result of solid solution alpha and beta phases formed which improve energy absorption in the alloy.
ilastik install and run for Syn Bot (Windows Version) v1
Authors: T Savage Justin
Published: June 2024

Video instructions for installing ilastik, training an ilastik project, and using the ilastik project for simple SynBot run for Windows operating system.
Installing FIJI and SynBot (Windows Version) v1
Authors: T Savage Justin
Published: June 2024

Video instructions for installing FIJI and SynBot and a simple SynBot run for Windows operating system.
Immunofluorescence staining on larval and adultDrosophilagonads v1
Authors: Goetting Samantha
Published: June 2024

Immunofluorescence staining protocol for Drosophila gonads
Examination of Mathematics Course Contents Related to Proof in the Educational Informatics Network
Authors: Cihan Fikret
Published: June 2024

This research aims to examine the mathematics course contents related to proof in the Educational Informatics Network. The document analysis method was used in this qualitative research. The data of the study consisted of 35-course contents related to proof in the Educational Informatics Network. These contents were subjected to content analysis. According to analysis results, it has been determined that there isn’t enough proof in the contents of the Educational Informatics Network for all grade levels and in all learning domains. Although not in sufficient numbers, the proofs in these contents mostly consist of proofs belonging to the “Geometry” learning domain. The number of proofs in the “Numbers and Algebra” learning domain is limited. It is seen that no proof of the “Data, Counting, and Probability” learning domain is included. In line with the results of this research, it can be suggested to produce more content related to proof suitable for cognitive developments and grade levels by making the most of the potential of technology for all grade levels and all learning domains.
Mathematics Teachers’ Experiences Teaching of the Online Distance Education During the COVID-19 Pandemic: Concerns and Adaptations
Authors: Güzel Mehmet , Coşkun Medine , Asil Güzel Ayşe , Bozkurt Ali
Published: June 2024

The purpose of this study was to investigate how mathematics teachers make sense of their experiences teaching in distance education settings during Covid-19 pandemic in 2020-2022. Interpretative phenomenological analysis was used to design this study which is based on the phenomenological pattern. Eight teachers with at least seven years of professional experience participated in the study. Data were collected through semi-structured interviews and interpreted by interpretative phenomenological analysis. As a result, the following four main themes were identified: struggle adaptation & reflection, lack of interaction, tension between authority and autonomy, and concerns about professional competence. According to the themes identified, teachers underwent a search and struggle process as they attempted to adapt themselves and their students to the new situation from the beginning of the period.
Matematik Öğretmen Adaylarının Gözünden Eğitsel Oyun Materyallerinin Tasarımı, Geliştirilmesi ve Değerlendirilmesi
Authors: Özçakır Bilal , Özdemir Duygu
Published: June 2024

Montaigne’in de dediği gibi “Çocukların oyunu, oyun değil, onların en ciddi uğraşıdır.” Çünkü çocuklar oyun oynarken bilişsel, sosyal ve duygusal anlamda aktif ve gelişime çok açıktır. Ancak öğrenciye olan yakınlığına rağmen, oyunla öğrenme ya da pekiştirme sağlayacak materyaller hakkında ortaokul matematik eğitimi ile ilgili erişilebilir alan yazında ve uygulama alanında önemli eksiklikler bulunmaktadır. Bu bağlamda, matematik öğretimini oyunlarla desteklemeye yönelik oyun materyallerinin öğretmen adayları tarafından tasarlanması ve sürecin değerlendirilmesi amaçlanmaktadır. Tasarım tabanlı araştırma yöntemi çerçevesinde yürütülen bu çalışmada, prototipler şeklinde tasarlanan, sürekli değerlendirilerek düzenlenen ve uygulama olanakları ile geliştirilen matematik eğitim materyali olarak oyunlar oluşturulmuş ve bu sürece yönelik tasarım ilkelerine yönelik çıkarımlar yapılmıştır. Bu tasarım ve uygulama deneyiminin öğretmen adaylarının profesyonel gelişimine ve pedagojik bilgi ve beceri birikimlerinin genişlemesine de önemli katkılar sağladığı görülmüştür.
On a New Transmuted Three-Parameter Lindley Distribution and Its Applications
Authors: Xi Yuhang , Lu Hezhi , Liang Fei
Published: June 2024

In this paper, a new transmuted three-parameter Lindley distribution (TTHPLD) is established using the transmutation map method, which includes the Lindley distribution, two-parameter Lindley distribution, transmuted two-parameter Lindley distribution and three-parameter Lindley distribution as special cases. The statistical properties of the TTHPLD model, which are based on moments, order statistics, hazard rate functions, reliability functions, and Renyi entropy, have been studied. Moreover, the maximum likelihood estimators (MLEs) of the TTHPLD are obtained via differential evolution algorithms, and a simulation study is conducted to evaluate the consistency of the MLEs. Finally, the proposed distribution is applied to a real dataset and compared with other well-known models.
Polymetallic tungsten skarn mineralisation related to the Periadriatic intrusion at Lienzer Schlossberg, East Tyrol, Austria
Authors: Raith Johann G. , Hutter Florian , Altenberger Florian , Weilbold Julia , Auer Christian , Krause Joachim , Berndt Jasper , Neinavaie Hassan
Published: June 2024

A regional tungsten anomaly was discovered and explored in the Lienzer Schlossberg area that is part of the crystalline Austroalpine nappe complex of the Eastern Alps in the 1970/80-ties. Tungsten is present as scheelite, which occurs in steeply SSW dipping WNW-ENE oriented quartz veinlets and joints within the porphyritic dioritic to tonalitic/granodioritic host rocks of the Oligocene Lienz/Edenwald intrusion and in the exoskarn, which developed at the contact of the intrusion with Ca-rich lithologies. The skarn system is characterised by two stages: (1) a primary high-temperature calc-silicate stage characterised by grossular, diopside-hedenbergite, vesuvianite, wollastonite and Ca-plagioclase and (2) a retrograde skarn stage including scheelite-bearing massive sulphide ores (pyrrhotite, chalcopyrite, tremolite-actinolite, diopside-hedenbergite) and scheelite-rich fault rocks with calcite, sericite and chlorite. The two ore stages, the mineral paragenesis and composition is like that of a reduced tungsten skarn; i.e., garnet is grossular-rich, clinopyroxene is diopside-hedenbergite. Vesuvianite contains up to 1.8 mass % fluorine. Scheelite has been studied by cathodoluminescence (CL), electron probe microanalysis and laser ablation-inductively coupled plasma-mass spectrometry. Three types of scheelite (Scheelite 1–3) are distinguished. In short-wave UV light, all types show blue fluorescence but CL revealed internal micro-textures in scheelite grains which are dominated by oscillatory zoning. Prolonged hydrothermal activity is indicated by dissolution-replacement and overgrowth textures affecting the primary zonation and trace element composition of scheelite. The distribution of rare earth elements (REE) in Scheelite 1 in tonalite-hosted quartz veinlets shows a convex (i.e., middle REE-enriched), heavy REE-depleted pattern with negative Eu anomalies (EuA
). The evolution of REE patterns from skarn-hosted Scheelite 2 and 3 illustrates a gradation of convex REE patterns with high ΣREE and distinct negative Eu anomalies to relatively flat REE patterns with small to no EuA
. Scheelite at Lienzer Schlossberg has one of the highest ΣREE+Y contents of all scheelite-bearing ore settings in the Eastern Alps but incorporates minor Mo and the least Sr. High Na and Nb contents together with the positive correlation of REE+Y vs. Na+Nb+Ta suggests that the main exchange vectors for REE incorporation in scheelite is via a combined coupled substitution mechanism. Results of this study confirm the genetic similarity with reduced tungsten skarns and highlight the tungsten potential of this area.
Identity of the pathogenesis, genetic and epigenetic mechanisms of osteoarthritis and rheumatoid arthritis development
Authors: Mustafin Rustam N.
Published: June 2024

Osteoarthritis is characterized by heterogeneity of clinical manifestations and, in some cases, a severe progressive course. In this regard, it is important to identify new molecular targets for the treatment of the disease. To determine the role of autoimmune processes, general genetic and epigenetic changes in osteoarthritis and rheumatoid arthritis, as well as to identify osteoarthritis-specific ribonucleic acids (microRNAs), potential targets for targeted therapy, information was searched using scientific platforms PubMed, Scopus, ResearchGate, RSCI over the past 10 years. Although the pathogenesis of rheumatoid arthritis and osteoarthritis differs, evidence has been obtained that identical pathological immune reactions are involved in the mechanism of osteoarthritis and disruption of the expression of 26 identical genes with identical changes in the levels of 13 of them. Changes in the expression of the same microRNAs (miR-140, miR-149, miR-25, miR-146a, miR-16, miR-23b) were detected in osteoarthritis and rheumatoid arthritis. Molecular genetic studies make it possible to find new markers of pathological immune reactions in osteoarthritis, which can be used to treat the disease and prevent its rapid progression, as well as to design targeted therapy using gene expression products as targets. MicroRNAs associated with osteoarthritis and rheumatoid arthritis and involved in the pathogenesis of both diseases may become promising targets for targeted therapy of osteoarthritis and rheumatoid arthritis.
Architectural epistemology, existing buildings, and single-image modeling
Authors: Christenson Mike , Self Kallie
Published: June 2024

This paper examines an alternative approach to creating a 3D digital model of an existing building on the basis of a single photograph. Rather than prioritizing comprehensive coverage or geometric accuracy, the method aims to highlight how the modelmaking process itself can generate architecturally specific knowledge. The paper describes modeling the Nishiki Market in Kyoto using principles of projective geometry and reverse perspective. By problematizing the construction process, the method discloses how a model may embody subjective interpretations and choices. The paper argues that this approach legitimizes producing models counter to prevailing conventions, as the process itself constitutes a form of situational architectural understanding, registered through traces of the modelmaker and the photograph’s perspective. Rather than foregrounding usefulness, this method values uncovering hidden assumptions and exposing the contingencies involved in constructing architectural knowledge.
A Deep-Neural-Network-Based Prediction Model for Elastic Input Energy Spectra of Horizontal and Vertical Ground Motions
Authors: Yang Yu-Heng , Cheng Yin , Yang Yu-ping , Yuan Ran , He Yi
Published: June 2024

Intensity measures based on energy have proven to be robust indicators of damage for a variety of structural types. This article presents a modified ground-motion model (GMM) incorporating a deep neural network to predict elastic input energy spectra for both horizontal and vertical ground motions, considering the pulselike ground motions. The newly developed model employs six predictor variables, that is, moment magnitude Mw, fault mechanism F, rupture distance Rrup, logarithmic rupture distance ln(Rrup), rupture directivity term Idir, and logarithmic shear-wave velocity ln(VS30) as inputs. A subset of records, sourced from the recently updated Next Generation Attenuation-West2 Project database constituted by 2745 ground motions from 97 earthquakes, have been employed in the development of the model. The performance of the developed model remains within the prescribed error range. In addition, the proposed model is compared against currently used GMMs. The predicted spectra obtained from the present study are in good agreement with those given by other literature, and the standard deviations of residuals have been reduced by ∼20% and are more stable. Observations from these results indicate that the newly proposed model generates improved predictions.
Impacto del COVID-19 en la rentabilidad y liquidez de una Cooperativa Minera Rinconada y Lunar de Oro Limitada, Puno, Perú
Authors: Trujillo-Mamani Yenny Cintia , Huamantoma-Simon Cesia Adelia , Muñoz-Soncco Sonia , Incaluque-Sortija Rulli William , Cusilayme-Barrante Helfer Rude
Published: June 2024

El propósito principal de esta investigación fue evaluar cómo la rentabilidad y la liquidez de la empresa “Central de Cooperativas Mineras Rinconada y Lunar de Oro Limitada” se vieron afectadas por el COVID-19 entre los periodos 2018 y 2022. Este estudio se clasifica de tipo básica y nivel descriptivo, y no experimental. Para el recojo de información se usó la técnica de documentación y la observación, se analizó el Estado de situación financiera y Estado de Resultados de la empresa. Los resultados muestran que, según el análisis de rentabilidad por retorno de activos (ROA) en el 2019 mostró un valor negativo (-0,21). Mientras que en 2020 registró un valor 78,02. Por otro lado, el análisis del retorno sobre el patrimonio (ROE), en el 2019 se halló un valor de -0,14. Mientras que en el 2020 se registró un valor significativo en ls ratios (65,01). Respecto a la liquidez de la empresa minera, según valores de Liquidez Corriente en el 2019 fue de 15,46 y en el 2020 fue de 0,78. Por otro lado, los valores de la Prueba Ácida en el 2019 fueron de 15,46 y en el 2020 de 0,78. Conclusiones: la empresa minera percibió una caída importante en su liquidez, sin embargo, logró mantener una sólida rentabilidad económica y financiera. Aunque una empresa pueda ser rentable, la falta de liquidez representa un riesgo significativo.
Septic shock diagnosis and its treatment
Authors: Reshi Mohd Rafi , Nabi Nusrat , Muzaffar Muzamil , Anees Saman , Yusuf Nausheen , Qasim Atiya , Naqvi Maaz
Published: June 2024

In critical care, sepsis continues to be a major cause of mortality. The pathogenic, diagnostic, and therapeutic panorama of sepsis is no longer restricted to the critical care unit: many patients who enter treatment through other doors, both inside and outside the hospital, develop severe illness. Next, administer fluids and broad-spectrum antibiotics after taking the proper cultures. Step up the treatment to include monitoring urine output, blood gases for base excess, lactate, haemoglobin, and glucose if the situation does not get better within the following six hours. These will dictate how bicarbonate, insulin, fluids, transfusions, and vasopressors are managed. The patient should be sent to intensive care if the hypotension doesn't improve (septic shock). Sepsis can now be treated with methods that have produced better results with other illnesses. New medicines have been created as a result of a better understanding of the biology of severe sepsis and septic shock, placing a strong emphasis on early detection and aggressive treatment. The major priorities continue to be prevention through screening, preventing cross infection, and prudent antibiotic usage.
Examining the prevalence of cardiovascular complications among individuals with early-onset type 2 diabetes: a cross-sectional analysis at a tertiary care hospital
Authors: Ali M. Shawqat , Rabbani Golam Mahfuz , Islam Mohammad Touhidul , Khalid Muhammad Fazlul Haque , Islam M. Monirul , Uddin M. Hamid
Published: June 2024

Background: Type 2 diabetes mellitus poses a global health threat, with over 60% of cases in Asia. T2DM significantly increases the risk of diabetic cardiomyopathy and cardiovascular disease, contributing to heart failure through mechanisms like myocardial infarction. Diabetic patients face a two to fourfold increased likelihood of developing coronary artery disease and myocardial infarction. The objective of this investigation was to assess the frequency of cardiovascular complications in individuals with early-onset type 2 diabetes.
Methods: This cross-sectional observational study was conducted at the Department of Cardiology, Jashore Medical College, Jashore, Bangladesh. The study duration was one year from January 2023 to December 2023. and focused on adult Type 2 Diabetes patients admitted to tertiary care wards. Inclusion criteria encompassed ages 20-35, both sexes, Type 2 Diabetes diagnosis, and voluntary participation. Exclusion criteria included age under 20, severe concomitant diseases, Gestational Diabetes, advanced renal failure, and Type 1 Diabetes.
Results: This study analyzed 270 cases, with participants predominantly aged 32-35 years (48.52%). Gender distribution showed 56.36% female and 43.64% male participants. Echocardiographic findings revealed normal electrocardiograms in 81.82% of cases, with myocardial infarction observed in 16 cases showing diverse cardiac abnormalities. Diabetic patients exhibited left ventricular diastolic dysfunction 1(0.91%) and hypertrophy 2(1.82%).
Conclusions: The high prevalence of risk factors like obesity and hypertension highlights the intricate connection between metabolic and cardiovascular health. Early monitoring and intervention in young adults with type 2 diabetes are crucial for reducing cardiovascular risks.
The scourge of carbapenem resistant Enterobacteriaceae: how to fight back
Authors: Samel Samveda S. , Mandrekar Suruchi S. , Walse Prashant N. , Iqubal Syed Haroon , Bafna Raja Y. , Singh Mrityunjay K. , Alwani Paresh P. , Dholu Bharatkumar D.
Published: June 2024

The Enterobacteriaceae species cause both community acquired and health care associated infections like bloodstream infections, ventilator-associated pneumonia, intra-abdominal infections and urinary tract infections. Carbapenem-resistant Enterobacteriaceae (CRE) have been included in the list of global priority pathogens (GPP) declared by WHO in 2017. These infections pose a serious threat due to the associated significant morbidity and mortality. The mechanisms of antimicrobial resistance in these organisms are numerous; however, β-lactamase genes carried on mobile genetic elements are a key mechanism for the rapid spread of these antibiotic-resistant strains on a global scale. The carbapenem resistance (CR) in Enterobacteriaceae has been recognized for the past two decades, but the carbapenemase-producing Enterobacteriaceae (CPE) has been a more recent issue and is spreading at an alarming pace worldwide. In this article, we conducted a systematic literature search of the PubMed, Embase, Web of Science and Cochrane Library databases to identify relevant studies that reported the epidemiology and the outcomes for hospitalised patients with confirmed infections due to CRE and carbapenem-susceptible Enterobacteriaceae (CSE) published between 1 January 2010 and 30 August 2023.The results emphasize that patients with CRE infection still face a greater risk of mortality and need an urgent need for newer antibiotics and appropriate treatment regimens to reduce the risk of morbidity and mortality.
Diagnosis and management approach of acute cholangitis with sepsis complications in a peripheral hospital: a case report
Authors: Bria Maria D.
Published: June 2024

Acute cholangitis is a systemic, life-threatening condition that develops as a result of obstruction and infection of the bile ducts. The two main processes leading to acute cholangitis include obstruction of the biliary tract and the growth of bacteria in the bile. A case of acute cholangitis has been reported at Rote Ndao public hospital, Rote Ndao district, East Nusa Tenggara, in a 57-year-old woman, with the main complaint of right upper abdominal pain, jaundice, and fever. The diagnostic approach is based on anamnesis, physical examination, and supporting examinations. Based on the Tokyo guideline 2018 (TG18) the patient met a suspected diagnosis, with A criteria that was evidence of systemic inflammation in the form of fever (body temperature 38.7o C), evidence of an inflammatory response with increasing leukocyte count (26,200/cm3), and for the B criteria that was evidence of cholestasis in the form of jaundice, increasing of total bilirubin (19.8 mg/dL), abnormal liver function tests (SGOT 135 IU/L, SGPT 74 IU/L), while C criteria cannot be performed due to limited hospital imaging facilities. Limitations of investigations should not limit the diagnosis and initial management so it can give the good prognosis. Even though there were complications of sepsis, the patient did not experience signs of shock which could lead to mortality.
Leptospirosis-induced transverse myelitis and multiorgan failure: an uncommon manifestation in non-epidemic setting
Authors: Gul Muhammad Hamza , Siddiqui Aisha , Siddiqui Farina Fatima , Ahmad Waqas , Wardak Abdul Baseer , Oza Yugam Rajeshkumar
Published: June 2024

Leptospirosis is a disease that can be transmitted from animals to humans. It is caused by a bacterium called Leptospira interrogans and is more common in tropical and subtropical regions. Despite being the most neglected tropical disease, it is a significant emerging and re-emerging disease, according to recent reports and reviews by the World Health Organization (WHO). Leptospirosis is widespread among humans and animals globally, and it is estimated that there are 1.03 million cases and 58,900 deaths annually, with a case fatality rate of 6.85%. Acute transverse myelitis (TM) is a rare neurological disease that affects the spinal cord. It is caused by various autoimmune reactions and is usually limited to several spinal cord segments. It has a poor prognosis. Our case report presents a unique situation where a patient developed multiorgan failure due to leptospirosis and also had a rare co-presentation of transverse myelitis.
Evaluación semiautomática de contenidos de Planes Directores de TIC con tecnologías de Procesamiento del Lenguaje Natural
Authors: Airton Capuano Ethel Airton
Published: June 2024

Este artículo presenta los resultados de una investigación sobre búsqueda textual y evaluación semiautomática de contenidos relevantes sobre los Planes Directores de Tecnologías de la Información y la Comunicación publicados por una muestra representativa de órganos públicos del gobierno federal. Utilizando tecnologías de procesamiento del lenguaje natural, se extrajo información útil de los documentos de los planes investigados para evaluar el estado del arte de las TIC en los órganos, y se obtuvo resultados interesantes, algunos de los cuales causaron sorpresa (por casualidad), como el modelo de gestión de demandas en algunas unidades de TIC basado en estimaciones de la capacidad de entrega de los equipos. Se concluye que los planes cumplen con las normas oficiales, observándose incluso un interés de la mayoría de los órganos en temas de gestión actuales, como la gobernanza y la gestión de riesgos, y una madurez en la evaluación de las tendencias del mercado, pero también que sus contenidos aún carecen de perspectivas para algunas prácticas importantes que orienten su evolución técnica.
Curso sobre salud bucal dirigido a cuidadores de la primera infancia.
Authors: Castelblanco Restrepo Martha Elena , Triana Ruiz Lina María , Ochoa Maria Juliana , Solórzano Quina Laura Tatiana , Zorro Luna Paola Camila
Published: June 2024

ANTECEDENTES:  El ENSAB IV reporta que los niños de uno, tres y cinco años de edad tienen en promedio 2,69 dientes con cambios visibles en el esmalte, y el índice ceo es de 1,62, ratificando que los problemas de salud oral en la primera infancia son muy frecuentes en Colombia. Por lo tanto, es importante empoderar a los cuidadores de la salud bucal de los niños.  OBJETIVO: diseño, implementación y evaluación utilizando la metodología ABP de un curso híbrido de salud bucal dirigido a cuidadores de menores de cinco años. MÉTODO: Inicialmente se realizó una encuesta diagnóstica a cuidadores de instituciones educativas de primera infancia, para determinar las principales necesidades. El curso con metodología híbrida y sincrónica se diseñó en un aula virtual (Moodle) y se dividió en cuatro módulos: el primero: importancia del rol del cuidador y autoexamen oral; el segundo: principales enfermedades bucales de la infancia; el tercero: estrategias preventivas en instituciones educativas y cuarto: incluyó la evaluación mediante la resolución de un caso problema en salud bucal, finalmente se aplicó una encuesta de satisfacción del curso. RESULTADOS: En total participaron 56 cuidadoras, 19 de ellas participaron en el curso virtual sincrónico y 37 en el curso presencial. Se recibieron 5 casos problema resueltos satisfactoriamente y 34 de participantes evaluaron el curso refiriendo que las herramientas y las temáticas utilizadas fueron muy apropiadas, expresaron que fue un curso didáctico y práctico. Sugirieron mejorar el lenguaje. CONCLUSIÓN: La experiencia que se tuvo en el curso resalta la importancia de seguir implementando este tipo de ambientes de aprendizaje para capacitar e informar a cuidadores en el cuidado de la salud bucal de menores de cinco años.
Development of Islamic boarding school curriculum through equalization policies
Authors: Firdaus Wildani , Mardiana Dina
Published: June 2024

This study aims to find out the existence of the mu'adalah curriculum in the global era as well as to know the challenges of implementing the mu'adalah curriculum after the issuance of the Minister of Religious Affairs Regulation (PMA) number 18 of 2014. Global changes, technological and scientific developments, and the development of art and culture are the basis for changes in the education system, namely the curriculum. This is done so that educational institutions, especially Islamic boarding schools, can adapt and be able to compete with existing developments. This research method uses a qualitative approach with the type of library research. The results of this study state that the existence of Islamic boarding schools has not regressed at all to date. This is because Islamic boarding schools  received recognition from the government with the mu'adalah policy which was strengthened by the birth of the Minister of Religious Affairs Regulation (PMA) Number 18 of 2014 which was able to make Islamic boarding schools able to compete with any educational institution. But of course, challenges related to it cannot be avoided. One of them, some people question the quality of mu'adalah Islamic boarding school graduates who do not take the national exam.
Junior High School Students' Proportional Reasoning Ability in the Domain Comparison: A Gap in Results Between Indicators
Authors: Lutfi Ahmad , Dahlan Jarnawi Afgani , Martadiputra Bambang Avip Priatna , Jupri Al , Rusyid Husnul Khatimah , Mukhibin Ahmad
Published: June 2024

The purpose of this study was to analyze students' proportional reasoning ability. The research subjects consisted of 21 students of VIII class in one of the public junior high schools in Semarang City who had obtained comparison materials (ratio and proportion). Data collection used test instruments that were developed based on indicators of proportional reasoning ability consisting of 6 questions. The data were analyzed qualitatively with data reduction analysis procedures, data presentation, and conclusion drawing/verification. The results showed that (1) none of the students met all the indicators of proportional reasoning ability, namely the ability to understand proportional relationships, solve proportional problems of missing values, numerical comparisons, qualitative predictions, distinguish proportional and non-proportional problems, and solve proportional relationships of inverse values, (2) all students have been able to understand proportional relationships, but they are still very limited in their ability to distinguish proportional and non-proportional problems, and solve proportional relationships of inverse value, and (3) the strategy most often used by students to solve proportional reasoning problems is the cross-multiplication strategy.
Designing a Multiple-Epitope Vaccine Candidate against Leishmania major and Leishmania infantum for Monocyte-Derived Exosome Preparation
Authors: Moazezi Ghavihelm Ali , Nabian Sedigheh , Jamshidi Shahram , Taheri Mohammad , Soltani Minoo , Mazaheri Nezhad Fard Ramin , Akbari Pazoki Ali
Published: June 2024

Background: Leishmania is a vector-borne protozoon, which causes visceral, cutaneous and mucocutaneous leishmaniosis in human and animals. Monocyte-derived exosome vaccines can be used as prophylaxis and immunotherapy strategies. The aim of this study was to design a multiple-epitope candidate vaccine using leishmaniolysin (GP63) and rK39 proteins against Leishmania major and L. infantum for monocyte-derived exosome preparation.
Methods: This study was carried out in Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran, 2023–2024. Effective immunodominant epitopes were selected from two antigenic proteins of GP63 and rK39 using various immunoinformatics and bioinformatics approaches. Vibrio cholerae β-subunit was used as an adjuvant to stimulate immune responses. Then, appropriate linkers were selected for the fusion of epitopes. The 3D model of candidate vaccine was predicted and validated.
Results: This designed candidate vaccine could effectively be used as a prophylaxis strategy against leishmaniosis.
Conclusion: A candidate vaccine was designed using bioinformatic and immunoinformatic studies with virtual acceptable quality; however, effectiveness of this vaccine should be verified through further in-vitro and in-vivo studies.
Comparing the Yield of Recombinant Human Factor VII Protein Expressed by the rDNA-Promoter with the CMV-Promoter in Iranian Lizard Leishmania
Authors: Abdi Ghavidel Afshin , Bandehpour Mojgan , Noori Effat , Jajarmi Vahid , Kazemi Bahram
Published: June 2024

Background: Iranian Lizard Leishmania (I.L.L) is a nonpathogenic Leishmania strain. Due to its advantages, several recombinant proteins have been produced in this host. However, I.L.L shows a lower yield of recombinant protein expression compared to other commercial hosts. Considering the role of protease enzymes in protein digestion, we selected cysteine protease B (CPB) to investigate its impact on recombinant protein yield in I.L.L.
Methods: we generated gene knockouts by utilizing homologous recombination (HR) and CRISPR methods. To assess the efficacy of the designed construct, we compared the yield of recombinant human factor VII (rhFVII) production between cells transfected with the pLEXSY-hyg2-FVII vector and the CMV-promoter-based construct (pF7cmvneo).
Results: The knockout of a single CPB gene allele through the HR method or the complete knockout of all alleles through the CRISPR method led to cell death. This outcome suggests that even the deletion of a single CPB gene allele diminishes the protein to a level insufficient for the survival of I.L.L, indicating a critical dependency on the presence of this protein for the organism's viability. rhFVII exhibited a greater expression yield with the pLEXSY construct compared to the pF7cmvneo construct in I.L.L. The lower expression rate of pF7cmvneo may be influenced by epigenetic factors related to the CPC gene or the RNA polymerase used for the expression of that promoter.
Conclusion: Therefore, considering alternative integration targets for CMV-promoter-based constructs and incorporating UTR sequences of I.L.L high-expression proteins in the vector may enhance recombinant protein expression rates.
Cytotoxic and Immunomodulatory Activity of Curcumin and Chitosan on Experimental Toxoplasmosis
Authors: Rezgi Mahsa , Yousefi Elham , Jafari Behzad , Asadi Negar , Khademvatan Shahram , S Howarth Gordon
Published: June 2024

Background: Toxoplasma gondii is a pathogenic parasite with worldwide distribution. We investigated curcumin and chitosan in combination on the viability of T. gondii tachyzoites in silico, in vitro and in vivo.
Methods: A 3D model was employed in Urmia University of Medical Sciences, Urmia, Iran in 2021 to study the interaction between curcumin and dihydrofolate reductase (DHFR). Ramachandran root-mean-square deviation and VERIFY3D validated the model. Cytotoxicity of curcumin and chitosan was evaluated by MTT viability assay. BALB/c mice infected with 104 Toxoplasma organisms were treated with curcumin, chitosan, and the combination of curcumin+chitosan. Serum levels of inducible NO synthetase (iNOs), interferon gamma (IFN-γ), interleukin (IL)-5, glutamate oxaloacetic transaminases(SGOT), and glutamic pyruvate transaminase (SGPT) were determined.
Result: Curcumin-DHFR and curcumin-DHPS (dihydropteroate synthase) interactions and calculated enzyme energy indicated an excellent affinity for curcumin with DHFR, but not DHPS. MTT results of concurrent treatments demonstrated IC50 rates of 0.1, 0.05, and 0.01 mg/ml at 24, 48, and 72h, respectively. IFN-γ, IL-5 and iNOs levels in curcumin+chitosan treated mice were 1.71, 0.51, and 1.51 IU/L, while those of SGOT and SGPT were 76 and 84 IU/L, respectively.
Conclusion: The combination of curcumin and chitosan increased survival time of infected mice by seven days. Curcumin and chitosan in combination regulated the immune system and reduced liver damage, potentially forming the basis of a new treatment for toxoplasmosis.
Evaluation of Nanonanoliposomal Curcumin on Cutaneous Leishmaniasis Skin Lesions Caused by Leishmania major in BALB/c Mice
Authors: Shirmohammad Sedigheh , Mohebali Mahdi , Arabkhazaeli Fatemeh , Hassan Jalal , Shayan David , Amininia Narges , Shayan Parviz
Published: June 2024

Background: Curcumin is an extract of rhizome turmeric (diferuloylmethane), with antioxidant, anti-inflammatory, antimicrobial, and anti-parasitic properties, which making it a potential candidate for the treatment of leishmaniasis. The aim of the presented study was to evaluate curcumin as possible candidate for treatment of cutaneous leishmaniasis. 
Methods: We investigated the physicochemical properties and anti-leishmanial effects of nanoliposomal curcumin (40, 80, and 120 μM) in Leishmania major (MRHO/IR/75/ER) infected BALB/c mice at the faculty of Veterinary Medicinem University of Tehran, Iran. For this aim, L. major promastigotes (MHROM/IR/75/ER) at stationary phase (2×106) were inoculated sub-cutaneously into the upper area of the tail in BALB/c mice (six groups, n= 10 per group). For evaluation of nanoliposomal curcumin, the zeta potential, particle size and stability of nanoliposomal curcumin was determined. Furthermore, the anti-leishmanial effects of nanoliposomal curcumin formulation on the lesion sizes was determined and the parasite burden in the leishmania induced lesion was performed using semi quantitative PCR.
Results: Treatment of L. major infected BALB/c mice with nanoliposomal curcumin led to a reduction in the kinetic of the skin lesion size development. The semi quantitative PCR analysis of DNA extracted from the lesions showed reduction of parasite burden. The most effective treatment could be found in 80 μM nanoliposomal curcumin. Treatment with Glucantime, as a positive control, also showed a nearly similar effect compared to the effect of 80 μM nanoliposomal curcumin.
Postpartum Spontaneous Rupture of a Primary Splenic Hydatid Cyst: A Case Report
Authors: Ashraf Aabid , Mittal Ritika
Published: June 2024

Hydatid disease is endemic in some regions of the world. Even in endemic regions, splenic hydatid cysts are rare, especially in pregnancy. The most serious presentation is intra peritoneal rupture, which is a surgical emergency. Exploration with splenectomy is the favoured management. We present a case of splenic hydatid cyst, detected late in pregnancy, with intraperitoneal rupture in the postpartum period. Cystic lesions located anywhere in the body in endemic regions could be hydatid cysts. Prompt treatment should be planned immediately on detection in order to prevent potentially serious complications like rupture.
The Hepatic Phase of Fascioliasis Complicated with Liver Bleeding: Presentation of Three Cases
Authors: Uçmak Feyzullah , Kaya Muhsin
Published: June 2024

Bleeding is a very rare complication of Fasciola species (F. hepatica or F. gigantica) infection. We present here three cases of subcapsular liver bleeding caused by the hepatic phase of Fasciola spp. infection in patients, two of whom were women, aged 22, 66, and 84 years in Diyarbakir Province, southeastern Turkey. They had symptoms of right upper quadrant pain (n = 3), nausea (n = 1), and vomiting (n = 2) for periods ranging from 6 hours to 15 days. All patients with clinical presentations ranging from moderate abdominal pain to hypovolemic shock and ischemic hepatitis were improved with supportive treatment without the need for surgery. They showed complete clinical and laboratory recovery after triclabendazole administration in their follow-up. In conclusion, Fasciola spp. infection should be considered in the etiology of bleeding from liver disease.
Is Vermicomposting the Best Option for Eliminating Antibiotic Resistance Genes (ARGs)?
Authors: Ghandehari Yazdi Farnaz , Ebrahimi Ali Asghar
Published: June 2024

The Article Abstract is not Available.
Optimizing Microalgae Cultivation for Wastewater Phytoremediation and Biodiesel Production
Authors: Hatami Behnam , Rezaie Arezo
Published: June 2024

The Article Abstract is not Available.
Comparing Optimized Sound Absorption Coefficient of Aluminum Foam with Local Search Algorithm, Genetic Algorithm, and Particle Swarm Optimization
Authors: Fallah Madvari Rohollah , Niknam Sharak Mohsen , Jafari Mohammad Javad , Abbasi Balochkhaneh Faezeh
Published: June 2024

Introduction: The principle of passive sound control is based on the phenomenon of sound absorption by absorbers. The factors affecting sound absorption include porosity, pore size, pore opening size, thickness, and air flow resistance.
Materials and methods: In this study, the authors compared the optimization results of the effective parameters on sound absorption coefficient (AC) using the three optimization methods: Guided Local Search (GLS), Genetic Algorithm (GA) and Particle Swarm Optimization (PSO). The programming was done in MATLAB software. Thicknesses of 5, 10, 20, 30 and 40 mm were chosen for optimization at frequencies of 500 to 3000 Hz.
Results: In frequencies above 2 kHz (thickness 5 to 40 mm), the three optimal methods had the same performance and estimated AC of 1. At low frequencies of 2 kHz and thicknesses of 30 and 40 mm, GA and PSO methods obtained an AC of 1.
Conclusion: It seems that the GA and PSO optimization algorithm are suitable methods to optimize the AC of metal foam in low and high frequencies.
The Relationship between Pesticide Exposure and Liver and Renal Enzyme Disorders in Adults Aged 35-70: The Results of the First Phase of the Shahedieh Cohort Study
Authors: Zardosht Kosar , Momayyezi Mahdieh , Sefidkar Reyhane , Fallahzadeh Hossein , Momayyezi Mohammad , Ebrahimi Ali Asghar
Published: June 2024

Introduction: Liver and kidney are known as important organs in detoxification of the body and may be exposed to pesticide damage. This study aims to investigate the relationship between pesticide exposure and disorders of liver and renal enzymes.
Material and methods: This cross-sectional study was conducted on 5637 Iranian adults aged 35-70 from the first phase of Shahedieh Cohort Study. The investigated variables included age, sex, BMI, smoking, liver enzymes (SGPT, SGOT, ALP, GGT), renal enzymes (Urea, Creatinine), and the information related to exposure to pesticides in the yard, home, and agricultural land during the last 12 months. Data were analyzed using SPSS software version 24.
Results: The findings showed that 8% of the people were exposed to pesticides/ insecticides on agricultural land, 2% in yard, and 59.6% at home. The mean of liver and renal enzymes in people exposed to pesticides in agricultural land was higher than in non-exposed individuals. This relationship was significant for all the enzymes except GGT. People exposed to pesticides in the yard had significantly higher levels of renal enzymes than non-exposed individuals. People exposed to pesticides at home had significantly higher levels of liver enzymes and renal enzymes than the non-exposed ones. Moreover, the mean of liver and renal enzymes were lower in people who used personal protective equipment.
Conclusion: This study suggests that exposure to pesticides may impact liver and kidney functions, and taking precautions like using personal protective equipment can help minimize potential health risks.
The Effects of Environmental Values on Pro-Environmental Behavior and Attitude of Housewives in Rafsanjan, Southeast Area of Iran
Authors: Eslami Hadi , Mohseni Zohreh , Ranjbar Askari Foad , Mirzaeimoghadam Hooriyeh , Nasirzadeh Mostafa
Published: June 2024

Introduction: Indiscriminate consumption of energy, environmental pollution, and destruction of natural resources are among the most important issues related to pro-environmental behavior of people in society, and environmental values play an important role in shaping internal motivations of people about environmental issues. This study was conducted to determine the effects of environmental values on pro-environmental behavior and attitude of housewives in Rafsanjan, southeast area of Iran.
Materials and methods: This cross-sectional study was conducted on 200 housewives who were selected as random in health-care centers in Rafsanjan city. The data collection was done by a validated questionnaire regarding environmental values, attitude, and behavior. Pearson correlation, independent t-test, and ANOVA statistical tests were used to analyze data in SPSS.V22 software.
Results: The mean score of environmental values was 3.37 ± 26.76 (89.2%), which was significant according to the level of education (p = 0.016). The mean score of attitude and environmental values was 6.88 ± 40.65 (81.3%) and 40.22 ± 5.66 (80.44%), respectively. Also, there was a significant relationship between the score of pro-environmental behaviors and the level of education (p = 0.012). Pearson's correlation showed that there was a positive and significant relationship between environmental values and attitudes (r = 0.239, p = 0.01) and pro-environmental behaviors (r = 0.146, p = 0.01).
Conclusion: Based on the results, educated housewives believe more value for the environment, and have more appropriate pro-environmental behavior; thus, planning to sensitize society members, especially housewives, regarding the values of environmental protection through religious and cultural-based environmental education programs and increasing the level of education are recommended.