bluuebunny/crossref_metadata_2025 huggingface dataset:
Association of Homocysteine with Aysmptomatic Intracranial and Extracranial Arterial Stenosis in Hypertension Patients
Authors: Wang Yan , Zhang Jin , Qian Yuesheng , Tang Xiaofeng , Ling Huawei , Chen Kemin , Li Yan , Gao Pingjin , Zhu Dingliang
Published: January 2018

Elevated plasma homocysteine (Hcy) is suggested as an independent risk factor for stroke. We aimed to investigate the association of Hcy concentration with intracranial atherosclerosis (ICAS) and extracranial AS (ECAS) in hypertensive patients without stroke in Chinese population and to explore modified effect of methylenetetrahydrofolate reductase (MTHFR) C677T on their relationship. The stenosis of intracranial and extracranial arteries were evaluated in a total of 929 subjects through computerized tomographic angiography (CTA) from aortic arch to the skull base. Hcy concentration showed significantly association with both ICAS (OR: 1.105; 95% CI: 1.057–1.155) and ECAS (OR: 1.096; 95% CI: 1.047–1.146) for 1 µmol/L increment in Hcy. Meanwhile, hyperhomocysteinemia (≥15 µmol/L) was also displayed association with ICAS (OR: 1.587; 95% CI: 1.029–2.446) and ECAS (OR: 2.164; 95% CI: 1.392–3.364) after fully adjustment. Furthermore, in the subgroup analysis, such association remained significant only in the subjects that were younger, with normal renal function and with MTHFR 677 C allele. Our study showed the significant association of Hcy with ECAS and ICAS in asymptomatic hypertension patients. Hcy played a universal effect on the cervico-cerebral atherosclerosis. Such association was modified by the MTHFR C677T genotype.
Effects of larvae density and food concentration on Crown-of-Thorns seastar (Acanthaster cf. solaris) development in an automated flow-through system
Authors: Uthicke S. , Liddy M. , Patel F. , Logan M. , Johansson C. , Lamare M.
Published: January 2018

Coral-eating Crown-of-Thorns Sea stars (Acanthaster spp.) are major contributors to coral reef loss in the Indo-Pacific region. A release from food limitation of their planktotrophic larvae through enhanced pelagic productivity is one of the main hypothesis explaining population outbreaks (‘nutrient limitation hypothesis’). To improve the understanding of these outbreaks we developed an automated flow- through larvae rearing system that maintained food (microalgae) at set levels over the course of four 15d experiments. This resulted in stable food concentrations in experimental tanks. Increased algae concentrations had a significant positive effect on larval development and size at 10 and 15 days post fertilization (dpf). Larvae densities had no effect at 10 dpf. At 15 dpf greater larvae densities were associated with declines in larvae size. Larval development was slowed under higher larvae densities. Thus, the effects of algae concentration and larvae density were additive at 15 dpf, with larvae under low densities at a given algae concentration being further developed than those under higher densities. The development of a flow-through system gives greater insight into the effect of algae and larvae concentrations on Acanthaster development, and the system can be applied to further test the nutrient-limitation hypothesis for present and future outbreaks.
Large unexplained suite of chemically reactive compounds present in ambient air due to biomass fires
Authors: Kumar V. , Chandra B. P. , Sinha V.
Published: January 2018

Biomass fires impact global atmospheric chemistry. The reactive compounds emitted and formed due to biomass fires drive ozone and organic aerosol formation, affecting both air quality and climate. Direct hydroxyl (OH) Reactivity measurements quantify total gaseous reactive pollutant loadings and comparison with measured compounds yields the fraction of unmeasured compounds. Here, we quantified the magnitude and composition of total OH reactivity in the north-west Indo-Gangetic Plain. More than 120% increase occurred in total OH reactivity (28 s−1 to 64 s−1) and from no missing OH reactivity in the normal summertime air, the missing OH reactivity fraction increased to ~40 % in the post-harvest summertime period influenced by large scale biomass fires highlighting presence of unmeasured compounds. Increased missing OH reactivity between the two summertime periods was associated with increased concentrations of compounds with strong photochemical source such as acetaldehyde, acetone, hydroxyacetone, nitromethane, amides, isocyanic acid and primary emissions of acetonitrile and aromatic compounds. Currently even the most detailed state-of-the art atmospheric chemistry models exclude formamide, acetamide, nitromethane and isocyanic acid and their highly reactive precursor alkylamines (e.g. methylamine, ethylamine, dimethylamine, trimethylamine). For improved understanding of atmospheric chemistry-air quality-climate feedbacks in biomass-fire impacted atmospheric environments, future studies should include these compounds.
A novel approach for correction of crosstalk effects in pathway analysis and its application in osteoporosis research
Authors: Zhou Yu , Gao Yunlong , Xu Chao , Shen Hui , Tian Qing , Deng Hong-Wen
Published: January 2018

Osteoporosis is a prevalent bone metabolic disease and peripheral blood monocytes represent a major systemic cell type for bone metabolism. To identify the key dysfunctional pathways in osteoporosis, we performed pathway analyses on microarray data of monocytes from subjects with extremely high/low hip bone mineral density. We first performed a traditional pathway analysis for which different pathways were treated as independent. However, genes overlap among pathways will lead to “crosstalk” phenomenon, which may lead to false positive/negative results. Therefore, we applied correction techniques including a novel approach that considers the correlation among genes to adjust the crosstalk effects in the analysis. In traditional analysis, 10 pathways were found to be significantly associated with BMD variation. After correction for crosstalk effects, three of them remained significant. Moreover, the MAPK signaling pathway, which has been shown to be important for osteoclastogenesis, became significant only after the correction for crosstalk effects. We also identified a new module mainly consisting of genes present in mitochondria to be significant. In summary, we describe a novel method to correct the crosstalk effect in pathway analysis and found five key independent pathways involved in BMD regulation, which may provide a better understanding of biological functional networks in osteoporosis.
Correction: Corrigendum: Minocycline as a re-purposed anti-Wolbachia macrofilaricide: superiority compared with doxycycline regimens in a murine infection model of human lymphatic filariasis
Authors: Sharma Raman , Aljayyoussi Ghaith , Tyrer Hayley E. , Gamble Joanne , Hayward Laura , Guimaraes Ana F. , Davies Jill , Waterhouse David , Cook Darren A. N. , Myhill Laura J. , Clare Rachel H. , Cassidy Andrew , Steven Andrew , Johnston Kelly L. , Ford Louise , Turner Joseph D. , Ward Stephen A. , Taylor Mark J.
Published: January 2018

Scientific Reports 6: Article number: 23458; published online: 21 March 2016; updated: 08 January 2018 The original version of this Article contained a typographical error in the spelling of the author Ghaith Aljayyoussi, which was incorrectly given as Ghaith Al Jayoussi. This has now been correctedin the PDF and HTML versions of the Article.
Correction: Corrigendum: Dihydroartemisinin prevents breast cancer-induced osteolysis via inhibiting both breast cancer cells and osteoclasts
Authors: Feng Ming-Xuan , Hong Jian-Xin , Wang Qiang , Fan Yong-Yong , Yuan Chi-Ting , Lei Xin-Huan , Zhu Min , Qin An , Chen Hai-Xiao , Hong Dun
Published: January 2018

Scientific Reports 6: Article number: 19074; published online: 08 January 2016; updated: 08 January 2018 The original version of this Article contained an error in the title of the paper, where the word “cancer” was incorrectly given as “caner”. This has now been corrected in the PDF and HTML versions of the Article.
Analyzing the structure of macromolecules in their native cellular environment using hydroxyl radical footprinting
Authors: Chea Emily E. , Jones Lisa M.
Published: January 2018

Hydroxyl radical footprinting (HRF) has been successfully used to study the structure of both nucleic acids and proteins in live cells.
Rapid resolution of carbohydrate isomers via multi-site derivatization ion mobility-mass spectrometry
Authors: Li Li , McKenna Kristin R. , Li Zhao , Yadav Mahipal , Krishnamurthy Ramanarayanan , Liotta Charles L. , Fernández Facundo M.
Published: January 2018

Identifying small sugar isomers can be challenging by ion mobility-mass spectrometry (IM-MS) alone due to their small collision cross section differences.
Portable near infrared spectroscopy applied to abuse drugs and medicine analyses
Authors: Correia Radigya M. , Domingos Eloilson , Tosato Flavia , dos Santos Nayara A. , Leite Julia de A. , da Silva Mayara , Marcelo Marcelo C. A. , Ortiz Rafael S. , Filgueiras Paulo R. , Romão Wanderson
Published: January 2018

Near infrared (NIR) spectroscopy using a portable instrument (microNIR) associated with chemometrics models analysis was applied to quantify cocaine, and to classify synthetic drugs by their functional chemical composition.
Enzymatically cleavable traceless biotin tags for protein PEGylation and purification
Authors: Wawro Adam M. , Aoki Yusuke , Muraoka Takahiro , Tsumoto Kouhei , Kinbara Kazushi
Published: January 2018

Immobilized lipase was successfully employed for the rapid removal of a biotin tag from a protein–PEG conjugate under mild conditions.
Long-life sodium/carbon fluoride batteries with flexible, binder-free fluorinated mesocarbon microbead film electrodes
Authors: Liu Wen , Wang Yong , Li Yong , Shi Bin , Huang Ping , Guo Rui , Pei Haijuan , Zheng Yi , Lu Jiachun , Xie Jingying
Published: January 2018

Flexible, binder-free F-MCMB film electrodes enhance the cycle stability and achieve the longest lifespan reported thus far in sodium batteries.
Nine-step total synthesis of (−)-strychnofoline
Authors: Yu Qingzhen , Guo Pan , Jian Jie , Chen Yuye , Xu Jing
Published: January 2018

The asymmetric synthesis of an anti-cancer spirooxindole alkaloid, (−)-strychnofoline, has, for the first time, been accomplished in only nine steps.
Asymmetric [4+2] annulations to construct norcamphor scaffolds with 2-cyclopentenone via double amine–thiol catalysis
Authors: Yang Qian-Qian , Xiao Wei , Du Wei , Ouyang Qin , Chen Ying-Chun
Published: January 2018

A double catalytic system combining chiral amine and 2-mercaptobenzoic acid is applied for α′,β-regioselective [4+2] annulations of 2-cyclopentenone with diverse activated alkenes.
Three new compounds based on similar molybdenum–vanadium clusters and several types of copper complexes
Authors: Xiao Li-Na , Zhao Chun-Xiang , Shi Xiao-Ming , Zhang Hao , Wu Wen , Cui Xiao-Bing
Published: January 2018

A series of new organic–inorganic hybrid compounds based on Mo–V clusters and several types of transition metal complexes have been synthesized and characterized.
On the kinetic decomposition voltage of ternary oxides
Authors: Chun Jakyu , Martin Manfred , Yoo Han-Ill
Published: January 2018

The theoretical and experimental kinetic decomposition voltage in a ternary oxide under electric driving force.
Determination of derived volumetric properties and heat capacities at high pressures using two density scaling based equations of state. Application to dipentaerythritol hexa(3,5,5-trimethylhexanoate)
Authors: López E. R. , Fandiño O. , Cabaleiro D. , Lugo L. , Fernández J.
Published: January 2018

Scaling based EoSs describe the complex behavior of derived properties for broad temperature and pressure ranges from diPEiC9 experimental densities.
Binding affinity prediction of nanobody–protein complexes by scoring of molecular dynamics trajectories
Authors: Soler Miguel A. , Fortuna Sara , de Marco Ario , Laio Alessandro
Published: January 2018

Accurate binding affinity prediction of modelled nanobody–protein complexes by using the assistance of molecular dynamics simulations for achieving stable conformations.
Local and global aromaticity in a molecular carbon nanobelt: insights from magnetic response properties in neutral and charged species
Authors: Muñoz-Castro A.
Published: January 2018

The generation of local and global aromaticity in nanobelt structures can be modified according to different charge states.
The photocatalytic role of electrodeposited copper on pencil graphite
Authors: P. J. Arathi , Bhaskar Seemesh , G. Rajendra Kumar Reddy , P. Suresh Kumar , V. Ramanathan
Published: January 2018

Cu on pencil graphite as a photocatalyst.
Synthesis and characterization of Zn2GeO4/Mg-MOF-74 composites with enhanced photocatalytic activity for CO2 reduction
Authors: Zhao Hui , Wang Xusheng , Feng Jifei , Chen Yanning , Yang Xue , Gao Shuiying , Cao Rong
Published: January 2018

Zn2GeO4/Mg-MOF-74 composites are explored for artificial CO2 phototransformation under mild conditions.
Substitution of the laser borane anti-B18H22 with pyridine: a structural and photophysical study of some unusually structured macropolyhedral boron hydrides
Authors: Londesborough Michael G. S. , Dolanský Jiří , Jelínek Tomáš , Kennedy John D. , Císařová Ivana , Kennedy Robert D. , Roca-Sanjuán Daniel , Francés-Monerris Antonio , Lang Kamil , Clegg William
Published: January 2018

One-step derivatization of the laser borane, anti-B18H22, with pyridine gives three uniquely structured macropolyhedral boranes with interesting photophysical properties.
A new BODIPY-derived ratiometric senor with internal charge transfer (ICT) effect: colorimetric/fluorometric sensing of Ag+
Authors: Zhang Changli , Han Zhong , Wang Mengjia , Yang Zhenghao , Ran Xueqin , He Weijiang
Published: January 2018

BODIPY was modified with α-4-aminostyryl group to form a colorimetric/fluorometric dual mode ratiometric Ag+ sensor, and the sensor-doped PVC film enables the naked-eye Ag+ detection in totally aqueous solution.
Charge recombination control for high efficiency CdS/CdSe quantum dot co-sensitized solar cells with multi-ZnS layers
Authors: Wu Qiang , Hou Juan , Zhao Haifeng , Liu Zhiyong , Yue Xuanyu , Peng Shanglong , Cao Haibin
Published: January 2018

ZnS as an inorganic passivation agent has been proven to be effective in suppressing charge recombination and enhancing power conversion efficiency (PCE) in quantum dot-sensitized solar cells (QDSCs).
A novel trigonal propeller-shaped hybrid tri-neodymium-polyoxometalate exhibiting single-molecule magnet behavior
Authors: Zhang Hai-Long , Wu Xiao-Yuan , Liao Jian-Zhen , Kuang Xiao-Fei , Yang Wenbin , Lu Can-Zhong
Published: January 2018

A trigonal propeller-shaped hybrid polyoxometalate (POM) (NH2Me2)3{[Nd(Mo4O13)(DMF)4]3(BTC)2}·8DMF (1; BTC = 1,3,5-benzenetricarboxylate) has been synthesized and structurally characterized.
Crystal growth and aggregation in suspensions of δ-MnO2nanoparticles: implications for surface reactivity
Authors: Marafatto Francesco Femi , Lanson Bruno , Peña Jasquelin
Published: January 2018

Sodium content and suspension pH control crystallite size and aggregation in δ-MnO2nanoparticles.
Towards the real-time monitoring of industrial wastewater treatment processes via photoelectrochemical oxygen demand measurements
Authors: Aghasadeghi Kimia , Larocque Melissa J. , Latulippe David R.
Published: January 2018

Photoelectrochemical oxidation of different macromolecules was studied to investigate the potential of peCOD for use in industrial wastewater treatment.
A mineralogically-inspired silver–bismuth hybrid material: an efficient heterogeneous catalyst for the direct synthesis of nitriles from terminal alkynes
Authors: Ötvös Sándor B. , Mészáros Rebeka , Varga Gábor , Kocsis Marianna , Kónya Zoltán , Kukovecz Ákos , Pusztai Péter , Sipos Pál , Pálinkó István , Fülöp Ferenc
Published: January 2018

A silver-containing hybrid material is reported as an effective heterogeneous catalyst for the direct synthesis of organic nitriles from terminal alkynes.
A KI-mediated radical anti-Markovnikov addition of simple ketones/esters to unactivated alkenes
Authors: Tian Yunfei , Sun Changqing , Tan Ren Xiang , Liu Zhong-Quan
Published: January 2018

A KI-mediated radical anti-Markovnikov addition of simple ketones and esters to unactivated alkenes was developed.
Smartphone integrated optoelectrowetting (SiOEW) for on-chip sample processing and microscopic detection of water quality
Authors: Jiang Dongyue , Lee Seunguk , Bae Sung Woo , Park Sung-Yong
Published: January 2018

We present a smartphone integrated optoelectrowetting (SiOEW) device as a low-cost, portable tool for on-chip sample preparation and microscopic detection of water quality.
BINOL-based differential chromo-fluorescent sensor and its application in miniaturized 1-2/4-2 bit encoders and decoders
Authors: Gupta Akul Sen , Kumar Gulshan , Paul Kamaldeep , Luxami Vijay
Published: January 2018

A BINOL (1,1′-bi-2-naphthol)-based probe 1 with a diamide group has been synthesized and investigated for its photophysical behavior towards various cations and anions.
Ionothermal synthesis of magnetically-retrievable mesoporous carbons from alkyne-appended ionic liquids and demonstration of their use in selective dye removal
Authors: Ravula Sudhir , Larm Nathaniel E. , Liu Yi , Atwood Jerry L. , Baker Sheila N. , Baker Gary A.
Published: January 2018

Tailored metal-containing ionic liquids generate porous carbon suitable for selective dye sorption and Fenton chemistry by thermal cyclotrimerization of terminal alkynes.
Serine- and threonine-derived diamine equivalents for site-specific incorporation of platinum centers in peptides, and the anticancer potential of these conjugates
Authors: Kumbhakonam Sateeshkumar , Vellaisamy Kasipandi , Saroj Soumya , Venkatesan Nalini , D. Karunagaran , Kannoth Manheri Muraleedharan
Published: January 2018

A modular strategy that gives access to a library of peptide–Pt conjugates and their anticancer potential is presented.
Enhanced red luminescence and improved crystallinity in NaEu(WO4)2 phosphors: an electron beam irradiation study
Authors: Munirathnappa Archana K. , Petwal Vikash C. , Dwivedi Jishnu , Sundaram Nalini G.
Published: January 2018

Band gap engineering in NaEu(WO4)2 red phospors via dose-dependent EB irradiation: a new strategy for improving fluorescence intensity.
Structure, magnetic properties and DFT calculations of azido-copper(ii) complexes with different azido-bonding, nuclearity and dimensionality
Authors: Massoud Salah S. , Henary Maher M. , Maxwell Lindley , Martín Alejandro , Ruiz Eliseo , Vicente Ramon , Fischer Roland C. , Mautner Franz A.
Published: January 2018

Cu(ii) compounds derived from diamine substituted alkyl or phenyl groups with azido acting as the bridging ligand were synthesized and were structurally and magnetically characterized.
{[Ru(bda)]xLy}n cross-linked coordination polymers: toward efficient heterogeneous catalysis for water oxidation in an organic solvent-free system
Authors: Zheng Tao , Li Lianwei
Published: January 2018

Cross-linked coordination polymers (CCPs) with the formula {[Ru(bda)]xLy}n were developed as heterogeneous catalysts for water oxidation in an organic solvent-free system.
Synthesis, characterization, optical and electrochemical properties and antibacterial activity of novel BODIPY glycoconjugated dendrimers
Authors: Saravanan Velautham , Rajakumar Perumal
Published: January 2018

A new class of novel BODIPY glycoconjugated dendrimers with optical, electrochemical and antibacterial properties is reported.
Effect of geometry factors on the priority of σ-hole⋯π and π-hole⋯π bond in phosphorescent cocrystals formed by pyrene or phenanthrene and trihaloperfluorobenzenes
Authors: Li Lili , Wu Wen Xin , Liu Zheng Fei , Jin Wei Jun
Published: January 2018

The effect of geometric factors on the assembly of luminescent cocrystals between pyrene or phenanthrene and trihaloperfluorobenzenes.
Synthesis of TiO2@α-Fe2O3 core–shell heteronanostructures by thermal decomposition approach and their application towards sunlight-driven photodegradation of rhodamine B
Authors: Mahajan Jatin , Jeevanandam Pethaiyan
Published: January 2018

TiO2@α-Fe2O3 core–shell heteronanostructures that act as a good photocatalyst for the degradation of RhB were synthesized by a novel thermal decomposition approach.
Binding kinetics of ultrasmall gold nanoparticles with proteins
Authors: Lira André L. , Ferreira Rodrigo S. , Torquato Ricardo J. S. , Zhao Huaying , Oliva Maria Luiza V. , Hassan Sergio A. , Schuck Peter , Sousa Alioscka A.
Published: January 2018

The kinetics of nanoparticle–protein interactions is modulated by nanoparticle surface chemistry.
Nanoscale chemical imaging of solid–liquid interfaces using tip-enhanced Raman spectroscopy
Authors: Kumar Naresh , Su Weitao , Veselý Martin , Weckhuysen Bert M. , Pollard Andrew J. , Wain Andrew J.
Published: January 2018

New approach to TERS probe coating enables chemical imaging of liquid-immersed surfaces with nanoscale spatial resolution.
Michael addition of carbonyl compounds to nitroolefins under the catalysis of new pyrrolidine-based bifunctional organocatalysts
Authors: Castán A. , Badorrey R. , Gálvez J. A. , López-Ram-de-Víu P. , Díaz-de-Villegas M. D.
Published: January 2018

Novel bifunctional pyrrolidine-based organocatalysts applicable for the asymmetric Michael addition of aldehydes and ketones to nitroolefins have been developed.
One-pot cascade synthesis of azabicyclesviathe nitro-Mannich reaction andN-alkylation
Authors: Disadee Wannaporn , Ruchirawat Somsak
Published: January 2018

A cascade of double intramolecular cyclizationsviathe nitro-Mannich reaction andN-alkylation provides direct access to various ring systems of azabicycles.
Room temperature multicomponent polymerizations of alkynes, sulfonyl azides, and N-protected isatins toward oxindole-containing poly(N-acylsulfonamide)s
Authors: Xu Liguo , Zhou Fan , Liao Min , Hu Rongrong , Tang Ben Zhong
Published: January 2018

The development of a new polymerization methodology affords polymer materials with new structures and functionalities.
Synthesis of zeolitic tetrazolate-imidazolate frameworks (ZTIFs) in ethylene glycol
Authors: Li Min-Yu , Zhang Hai-Xia , Wang Fei , Zhang Jian
Published: January 2018

Ethylene glycol (EG) as a universal solvent is used to reproducibly synthesize zeolitic tetrazolate imidazolate frameworks (ZTIF-11 to 13) in high yields, among which the frl-type ZTIF-11 shows high chemical stability and porosity as well as remarkable CO2 gas separation.
Racemic trinorsesquiterpenoids from the Beihai sponge Spongia officinalis: structure and biomimetic total synthesis
Authors: Sun Dong-Yu , Han Guan-Ying , Yang Na-Na , Lan Le-Fu , Li Xu-Wen , Guo Yue-Wei
Published: January 2018

Two rare new furan butanolides, sponalisolides A (1) and B (2), were isolated from the Beihai sponge Spongia officinalis, and fully characterized by extensive spectroscopic analysis and biomimetic total synthesis.
Ion-pair electrostatic attraction-enhanced donor–acceptor interactions between the prototypic 1,4-dialkoxybenzene-viologen binding mode in water
Authors: Zhang Yao , Yu Shang-Bo , Yang Bo , Wang Hui , Zhang Dan-Wei , Li Zhan-Ting
Published: January 2018

Intermolecular ion-pair electrostatic attraction was demonstrated to remarkably enhance the donor–acceptor interaction between prototypic 1,4-dialkoxybenzene and viologen in water.
Electrooxidation of Pd–Cu NP loaded porous carbon derived from a Cu-MOF
Authors: Mirza Salma , Chen Hao , Gu Zhi-Gang , Zhang Jian
Published: January 2018

We have synthesized Pd–Cu NP loaded porous carbon through the direct carbonization of a porous Cu based MOF for efficient electrooxidation.
TE-C36 carbon: a new semiconducting phase with an all-sp3 bonding network
Authors: Xu Yanheng , Lu Yihua , Zhu Xi , Wang Min
Published: January 2018

TE-C36 carbon, possessing an all-sp3 bonding network, is a semiconductor with a direct band gap of 2.25 eV.
Design, synthesis, and insecticidal activity of novel 1-alkoxy-2-nitroguanidines
Authors: Yang Dongyan , Wan Chuan , Xiao Yumei , Che Chuanliang , Rui Changhui , Qin Zhaohai
Published: January 2018

In searching for new insecticidal lead compounds, a series of novel 1-alkoxy-2-nitroguanidine, guadipyr analogues bearing alkoxy groups were designed, synthesized and confirmed by 1H NMR, 13C NMR, high-resolution MS and X-ray diffraction.
Highly efficient mesoporous polymer supported phosphine-gold(i) complex catalysts for amination of allylic alcohols and intramolecular cyclization reactions
Authors: Gu Huoliang , Sun Xiong , Wang Yong , Wu Haihong , Wu Peng
Published: January 2018

Preparation of highly ordered mesoporous polymer supported gold(i) catalyst as efficient and recyclable catalysts for construction of carbon–hetero bond.
Approach control. Stereoelectronic origin of geometric constraints on N-to-S and N-to-O acyl shifts in peptides
Authors: Devaraj Neal K. , Perrin Charles L.
Published: January 2018

Intramolecular N-to-S or N-to-O acyl shifts in peptides are of fundamental and practical importance, as they constitute the first step in protein splicing and can be used for the synthesis of thioester-modified peptides required for native chemical ligation.
Rhodium(i)-catalyzed asymmetric [4 + 2] cycloaddition reactions of 2-alkylenecyclobutanols with cyclic enones through C–C bond cleavage: efficient access totrans-bicyclic compounds
Authors: Zheng Xinxin , Guo Rui , Zhang Guozhu , Zhang Dayong
Published: January 2018

We report a rhodium-catalyzed asymmetric formal intermolecular [4 + 2] cycloaddition reaction of 2-alkylenecyclobutanols with α,β-unsaturated cyclic ketones leading to synthetically usefultrans-bicyclic molecules.
Dynamics of networks in a viscoelastic and active environment
Authors: Grimm Jonas , Dolgushev Maxim
Published: January 2018

We investigate the dynamics of fractals and other networks in a viscoelastic and active environment.
Dual or multi carbonaceous coating strategies for next-generation batteries
Authors: Li Ping , Zhang Kan , Park Jong Hyeok
Published: January 2018

Dual or multi carbonaceous coatings construct continuous electron-transport pathways within the entire electrodes together with conformal surface protection.
Predicted bulk photovoltaic effect in hydrogenated Zintl compounds
Authors: Brehm John A.
Published: January 2018

Hydrogenated Zintl phase semiconductors are predicted to have significant bulk photovoltaic effect responses across the visible spectrum.
A new rigid diindolocarbazole donor moiety for high quantum efficiency thermally activated delayed fluorescence emitter
Authors: Kim Kwang Jong , Kim Gyeong Heon , Lampande Raju , Ahn Dae Hyun , Im Joon Beom , Moon Ji Su , Lee Jae Kyun , Lee Jae Yeol , Lee Ju Young , Kwon Jang Hyuk
Published: January 2018

We report a new electron donor moiety (diindolocarbazole) for high performances of thermally activated delayed fluorescence emitters.
Expérimenter la concertation : une clé pour des politiques environnementales plus efficaces ? Une démarche multi-acteurs innovante en Tunisie centrale
Authors: Braiki Houssem , Burte Julien , Imache Amar , Hassenforder Emeline , Habaieb Hamadi , Bouarfa Sami
Published: January 2018

La Tunisie cherche à réorienter ses politiques d’Aménagement et de conservation des eaux et des sols (ACES) afin qu’elles gagnent en efficacité, en s’appuyant sur des démarches participatives innovantes. Cette orientation s’inscrit dans des contextes ruraux souvent peu documentés où la dimension environnementale nécessite d’être objectivée. De plus, il existe peu d’espaces de dialogue et de concertation entre les principales catégories d’acteurs des espaces ruraux concernés. Cet article analyse une démarche participative originale conçue pour produire de l’information de qualité en valorisant les savoirs locaux, partager et prendre en compte les perceptions des différents acteurs, et enfin construire des consensus pour contribuer à l’élaboration de politiques d’ACES plus efficaces. L’évaluation mobilise un double dispositif comprenant des observateurs extérieurs et une enquête de satisfaction auprès des participants. Elle s’appuie sur une grille d’évaluation de cette démarche, de ses produits et des effets induits à court terme. La structuration progressive et adaptative de la démarche, les choix des acteurs, des lieux de réalisation des ateliers et le recours à un animateur neutre ont été des facteurs très importants pour satisfaire aux critères d’évaluation de la démarche. Le partage et la prise en compte des informations et des données collectées, mais aussi des expertises et perceptions des différents acteurs, a permis de produire des informations jugées satisfaisantes ou très satisfaisantes par la totalité des participants. Cela a nourri les connaissances de la quasi-totalité des acteurs et a contribué à une dynamique constructive d’apprentissage collectif. L’engagement et la mobilisation des acteurs, en particulier au niveau central, dans cet espace opérationnel de concertation sur les enjeux territoriaux, les pratiques agricoles et les ACES, ont montré une trajectoire d’ouverture vers la décentralisation du pouvoir politique.
Évaluation participative des impacts de la recherche sur le riz pluvial d’altitude à Madagascar de 1980 à 2015
Authors: Breumier Paloma , Ramarosandratana Arline , Ramanantsoanirina Alain , Brocke Kirsten vom , Marquié Catherine , Dabat Marie-Hélène , Raboin Louis-Marie
Published: January 2018

Le riz est l’aliment de base des Malgaches. Mais, sur les Hautes Terres de Madagascar, très fortement peuplées, les rizières ne permettent plus de couvrir les besoins en riz. Un programme de création variétale a été initié en 1984 par le FOFIFA et le CIRAD qui a abouti à la création de variétés de riz pluvial adaptées à l’altitude. Ces variétés ont permis le développement très rapide de la riziculture pluviale jusqu’à plus de 1800 m d’altitude. Une étude de l’impact de ces recherches a été réalisée avec la méthodologie « IMPRESS » (IMPact des REchercheS au Sud) du CIRAD qui se focalise sur l’évaluation participative des impacts et met en exergue la perception des changements par les agriculteurs. La réduction de la période de soudure et de la contrainte d’acheter du riz a été l’impact le plus important aux yeux des producteurs. Un impact assez inattendu qui en découle a aussi été évoqué de façon unanime : « l’augmentation de la tranquillité d’esprit ». L’approche participative a permis une compréhension fine de l’amélioration de la situation individuelle des exploitants.
Development of MgOx–TiOx coatings for modulation of Mg corrosion resistance
Authors: Hernández Rodríguez Eric Noé , Íñiguez Contreras Claudia Mariana , Márquez Herrera Alfredo , Zapata Torres Martín Guadalupe , Balvantín Gracía Antonio , Diosdado De la Peña José Angel , Mis Fernández Ricardo , Peña Chapa Juan Luis
Published: January 2018

The development and testing of protective coatings against corrosion for magnesium is reported. The coatings were based on the MgOx–TiOx composite and for their fabrication the reactive RF-sputtering technique in the co-deposition mode was employed. MgOx–TiOx coatings with chemical composition ranging from pure Mg oxides to pure Ti oxides, including its mixture, were obtained through the variation of the rate of the sputtering powers applied to the Mg and Ti targets. Characterization (XRD and XPS) showed changes in the crystalline structure according to the rate of the sputtering powers and confirmed the presence of MgO2, MgO, Ti2O3 and TiO2 in different proportions. Electrochemical polarization measurements (Tafel) made by employing the Hank's solution showed that both Vcorr and Icorr depend on the chemical composition of the coatings, having better corrosion resistance when the content of Ti oxides is higher. Results showed that corrosion resistance of Mg could be modulated by changing the chemical composition of the MgOx–TiOx coatings.
Enrichment of reactive macerals in coal: its characterization and utilization in coke making
Authors: Nag Debjani , Kopparthi P. , Dash P.S. , Saxena V.K. , Chandra S.
Published: January 2018

Macerals in coal are of different types: reactive and inert. These macerals are differ in their physical and chemical properties. Column flotation method has been used to separate the reactive macerals in a non-coking coal. The enriched coal is then characterized in order to understand the changes in the coking potential by different techniques. It is then used in making of metallurgical coke by proper blending with other coals. Enriched coal enhance the properties of metallurgical coke. This shows a path of utilization of non-coking coal in metallurgical coke making.
Anti-ADAMTS13 Antibodies and a Novel Heterozygous p.R1177Q Mutation in a Case of Pregnancy-Onset Immune-Mediated Thrombotic Thrombocytopenic Purpura
Authors: Roose Elien , Tersteeg Claudia , Demeersseman Ruth , Schelpe An-Sofie , Deforche Louis , Pareyn Inge , Vandenbulcke Aline , Vandeputte Nele , Dierickx Daan , Voorberg Jan , Deckmyn Hans , De Meyer Simon , Vanhoorelbeke Karen
Published: January 2018

In this study, we investigated a case of pregnancy-onset thrombotic thrombocytopenic purpura (TTP). The patient had severely decreased ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 motif, member 13) activity levels during acute phase and the presence of inhibitory anti-ADAMTS13 autoantibodies was demonstrated, which led to the diagnosis of immune-mediated TTP. However, ADAMTS13 activity was only mildly restored during remission, although inhibitory anti-ADAMTS13 antibodies were no longer detected. We hypothesized that genetic abnormalities could account for this discrepancy between ADAMTS13 activity and antigen. Genetic analysis revealed the presence of two heterozygous substitutions on the same allele: a single nucleotide polymorphism (SNP) c.2699C > T (p.A900V), located in the beginning of the T5 domain, and a mutation c.3530G > A (p.R1177Q) located in the third linker region of ADAMTS13. In vitro testing of those substitutions by expression of recombinant proteins revealed a normal secretion but a reduced ADAMTS13 activity by the novel p.R1177Q mutation, which could partially explain the subnormal activity levels found during remission. Although changes in the linker region might induce conformational changes in ADAMTS13, the p.R1177Q mutation in the third linker region of ADAMTS13 did not expose a cryptic epitope in the metalloprotease domain. In conclusion, we report on an immune-mediated pregnancy-onset TTP patient who had inhibitory anti-ADAMTS13 autoantibodies during acute phase, but not during remission. Genetic analysis confirmed the diagnosis of immune-mediated TTP and revealed the novel p.R1177Q mutation which mildly impaired ADAMTS13 activity.
Immunohistochemical WWOX Expression and Association with Angiogenesis, p53 Expression, Cell Proliferation and Clinicopathological Parameters in Cervical Cancer
Authors: Seabra Mariana Ataydes Leite , Cândido Eduardo Batista , Vidigal Paula Vieira Teixeira , Lamaita Rivia Mara , Rodrigues Angélica Nogueira , Silva Filho Agnaldo Lopes da
Published: January 2018

Objective The current study evaluated the expression of WW domain-containing oxidoreductase (WWOX), its association with clinicopathological features and with p53, Ki-67 (cell proliferation) and CD31 (angiogenesis) expression in patients with invasive cervical squamous cell carcinoma (ICSCC). To the best of our knowledge, no other study has evaluated this association.

Methods Women with IB stage-ICSCC (n = 20) and women with uterine leiomyoma (n = 20) were prospectively evaluated. Patients with ICSCC were submitted to type B-C1 radical hysterectomy and pelvic lymphadenectomy. Patients in the control group underwent vaginal hysterectomy. Tissue samples were stained with hematoxylin and eosin for histological evaluation and protein expression was detected by immunohistochemistry studies.

Results The WWOX expression was significantly lower in the tumor compared with the expression in the benign cervix (p = 0.019). The WWOX expression was inversely associated with the CD31 expression in the tumor samples (p = 0.018). There was no association between the WWOX expression with the p53 expression (p = 0.464) or the Ki-67 expression (p = 0.360) in the samples of invasive carcinoma of the cervix. There was no association between the WWOX expression and tumor size (p = 0.156), grade of differentiation (p = 0.914), presence of lymphatic vascular invasion (p = 0.155), parametrium involvement (p = 0.421) or pelvic lymph node metastasis (p = 0.310) in ICSCC tissue samples.

Conclusion The results suggested that WWOX may be involved in ICSCC carcinogenesis, and this marker was associated with tumor angiogenesis.
Myasthenia Gravis – Exacerbation and Crisis
Authors: Schroeter Michael , Thayssen Günther , Kaiser Julia
Published: January 2018

Myasthenic exacerbation and crisis are most critical incidences in myasthenia gravis. Even nowadays myasthenic crisis is a life-threatening condition, with a lethality of 2–3%. We review means of avoiding myasthenic exacerbation and crisis, elaborate on red flags and how to establish highly-active therapy in a timely manner. This includes the reasonable use of cholinesterase inhibitors, immunoadsorption or plasma exchange, as well as immunoglobulins and steroids. Immunosuppressive agents and monoclonal antibody therapy add to the therapeutic options.

Intensive care of myasthenic patients includes the management of dysphagia and delirium. Importantly, the perioperative management of patients undergoing thymectomy and weaning are specific challenges in the treatment of myasthenic patients in the ICU.

Establishing timely consequent immunosuppression and treatment of myasthenic patients in specialized outpatient centres help to avoid repetitive exacerbations and crises.
Juvenile Myasthenia Gravis
Authors: Marina Adela , Schara Ulrike
Published: January 2018

Juvenile myasthenia gravis (JMG) is an autoimmune disorder of neuromuscular transmission caused by production of antibodies against the postsynaptic membrane of the neuromuscular junction. Clinical signs in young children and adolescents range from isolated ocular symptoms to general muscular weakness and respiratory insufficiency. Clinical presentation of JMG in young children and adolescents shows distinct features compared to adults. Young children may show generalized muscular weakness already during the first two years of life, and in this group specific antibodies can be only slightly increased. Because of existing therapeutic options, an early diagnosis is important. In case of negative specific antibodies and onset of the first symptoms during infancy or early childhood, the diagnosis of a congenital myasthenic syndrome (CMS) must be considered and is not always clear to differentiate. Clinical symptoms, diagnostic procedures and therapeutic strategies with consideration of specificities of this age group are discussed.
Effects and Quality of Stroke Rehabilitation of BAR Phase D
Authors: Bussmann Marie-Luise , Neunzig Hans-Peter , Gerber Joachim , Steinmetz Jochen , Jung Svenja , Deck Ruth
Published: January 2018

Background Stroke is a major public health problem of enormous epidemiological significance. Each year, approximately 200.000 people in Germany suffer a stroke. Stroke is the third leading cause of death and the most common cause of acquired disabilities in adults. About one fourth of stroke survivors report severe limitations in activities of daily living three months after acute stroke. The most common post-stroke conditions are motor and cognitive dysfunctions as well as affective problems. Stroke rehabilitation plays a crucial role in coping with stroke sequelae. The large number of strokes and the often debilitating consequences raise the question to what extent participation can be increased by medical rehabilitation.

Methods A prospective, multicenter survey study was conducted in six neurological inpatient rehabilitation centers. Recruitment focused on patients with recent acute stroke and disease severity corresponding to BAR phase D. Patients completed questionnaires at three points of measurement: at the beginning and at the end of the inpatient rehabilitation and after four months. Primary outcome was participation, secondary outcomes included several parameters of subjective well-being. Furthermore, utilization of aftercare and satisfaction with the rehabilitation program were measured.

Results At the beginning of the rehabilitation, patients experienced severe limitations in participation and reduced subjective well-being. At the end of inpatient rehabilitation, significant improvements of small effect sizes for subjective well-being and medium effect sizes for participation were achieved. After four months, effects had decreased, yet improvements compared to baseline were still noticeable. Patient ratings of the rehabilitation program and the outcomes achieved were consistently positive. Two thirds of the patients were advised to make use of aftercare offerings and most patients (83%) participated in an aftercare program of any kind.

Conclusions The results of this study support the notion that stroke rehabilitation has significant and sustainable effects. Participation in particular seems to improve through medical rehabilitation. Partly decreased effects after four months raise the question of adequate aftercare.
Kolaviron and Garcinia kola Seed Extract Protect Against Ischaemia/Reperfusion Injury on Isolated Rat Heart
Authors: Oyagbemi Ademola , Bester Dirk , Esterhuyse Johan , Farombi Ebenezer
Published: January 2018

Background The incidence of cardiovascular diseases and its associated complications have increased greatly in the past three decades. The purpose of this study was to evaluate the acute cardioprotective effects of Garcinia kola (GK) seed extract and Kolaviron (KV) and determine mechanisms of action involving RISK signalling pathways.

Methods Male Wistar rats were used in this study. Hearts were excised and mounted on the Langendorff perfusion system. The control, group 1 was perfused with dimethyl sulfoxide (DMSO), group II with KV and group III with GK respectively. Western blot analyses were performed on frozen heart tissues.

Results Isolated rat hearts perfused with KV and GK attenuated apoptotic pathways with significant reduction in p38 MAPK protein phosphorylation, as well as reduction in total caspase 3, cleaved caspase 3 (Asp 175) and PARP cleavage. KV and GK also down-regulated p-JNK1 (Tyr 185) and p-JNK 2 (Thr 183) protein expression at the 10 min reperfusion time ponit. Cardioprotection was achieved in part, by enhancement of the reperfusion injury signalling kinase (RISK) pathway; as evidenced by significant increases in protein expresion of Akt/PKB and p-Akt/PKB (Ser 473) in KV and GK respectively.

Conclusions KV and GK supplementation led to significant increases in the expressions of survival proteins. It is noteworthy that both KV and GK supplementation offered cardioprotection in ischaemic/reperfusion injury rat heart model. In all, GK showed better cardioprotective effect that KV.
A 9-Week Nordic and Free Walking Improve Postural Balance in Parkinson’s Disease
Authors: Franzoni Leandro , Monteiro Elren , Oliveira Henrique , da Rosa Rodrigo , Costa Rochelle , Rieder Carlos , Martinez Flávia , Peyré-Tartaruga Leonardo
Published: January 2018

Aerobic training has a neuroprotective effect in people with Parkinson’s disease. Recent evidence indicates that Nordic walking seems a promising alternative due to positive outcomes in functional mobility. However, the effects of Nordic walking compared to free walking on static and functional balance parameters are still unknown. The aim of this study was to evaluate the effects of nine weeks of Nordic and free walking training on static and functional balance. The sample size was 33 individuals with eight dropouts, leaving 25 individuals in the final sample (Nordic Walking, n=14, Free Walking, n=11). The participants underwent two evaluations in the present randomized clinical trial, pre- and post-training, to determine average velocity and root-mean-square values from center of pressure with eyes open and eyes closed. The functional balance showed approximately 5% improvement for the two groups (p=0.04). The results indicate that nine weeks of Nordic and free walking training were enough to induce improvements in the proprioceptive system and functional balance.
Perspective: Opportunities for ultrafast science at SwissFEL
Authors: Abela Rafael , Beaud Paul , van Bokhoven Jeroen A. , Chergui Majed , Feurer Thomas , Haase Johannes , Ingold Gerhard , Johnson Steven L. , Knopp Gregor , Lemke Henrik , Milne Chris J. , Pedrini Bill , Radi Peter , Schertler Gebhard , Standfuss Jörg , Staub Urs , Patthey Luc
Published: January 2018

We present the main specifications of the newly constructed Swiss Free Electron Laser, SwissFEL, and explore its potential impact on ultrafast science. In light of recent achievements at current X-ray free electron lasers, we discuss the potential territory for new scientific breakthroughs offered by SwissFEL in Chemistry, Biology, and Materials Science, as well as nonlinear X-ray science.
Numerical and experimental study on the steady cone-jet mode of electro-centrifugal spinning
Authors: Hashemi Ali Reza , Pishevar Ahmad Reza , Valipouri Afsaneh , Părău Emilian I.
Published: January 2018

This study focuses on a numerical investigation of an initial stable jet through the air-sealed electro-centrifugal spinning process, which is known as a viable method for the mass production of nanofibers. A liquid jet undergoing electric and centrifugal forces, as well as other forces, first travels in a stable trajectory and then goes through an unstable curled path to the collector. In numerical modeling, hydrodynamic equations have been solved using the perturbation method—and the boundary integral method has been implemented to efficiently solve the electric potential equation. Hydrodynamic equations have been coupled with the electric field using stress boundary conditions at the fluid-fluid interface. Perturbation equations were discretized by a second order finite difference method, and the Newton method was implemented to solve the discretized non-linear system. Also, the boundary element method was utilized to solve electrostatic equations. In the theoretical study, the fluid was described as a leaky dielectric with charges only on the surface of the jet traveling in dielectric air. The effect of the electric field induced around the nozzle tip on the jet instability and trajectory deviation was also experimentally studied through plate-plate geometry as well as point-plate geometry. It was numerically found that the centrifugal force prevails on electric force by increasing the rotational speed. Therefore, the alteration of the applied voltage does not significantly affect the jet thinning profile or the jet trajectory.
Systematic errors in the determination of the spectroscopic g-factor in broadband ferromagnetic resonance spectroscopy: A proposed solution
Authors: Gonzalez-Fuentes C. , Dumas R. K. , García C.
Published: January 2018

A theoretical and experimental study of the influence of small offsets of the magnetic field (δH) on the measurement accuracy of the spectroscopic g-factor (g) and saturation magnetization (Ms) obtained by broadband ferromagnetic resonance (FMR) measurements is presented. The random nature of δH generates systematic and opposite sign deviations of the values of g and Ms with respect to their true values. A δH on the order of a few Oe leads to a ∼10% error of g and Ms for a typical range of frequencies employed in broadband FMR experiments. We propose a simple experimental methodology to significantly minimize the effect of δH on the fitted values of g and Ms, eliminating their apparent dependence in the range of frequencies employed. Our method was successfully tested using broadband FMR measurements on a 5 nm thick Ni80Fe20 film for frequencies ranging between 3 and 17 GHz.