bluuebunny/crossref_metadata_2025 huggingface dataset:
A Plastic‐Crystal Electrolyte Layer Promotes Interfacial Stability of Ni‐Rich Oxide Cathode in Li6PS5Cl‐Based All‐Solid‐State Rechargeable Li Batteries
Authors: Ma Ruojian , Liu Yaning , Fang Ruyi , Zhang Jun , Wang Ya‐Hui , Huang Hui , Gan Yongping , He Xinping , Xia Xinhui , Zhang Wenkui , Xia Yang , Xin Sen
Published: June 2024

Unfavorable parasitic reactions between the Ni‐rich layered oxide cathode and the sulfide solid electrolyte have plagued the realization of all‐solid‐state rechargeable Li batteries. The accumulation of inactive by‐products (P2Sx, S, POxn− and SOxn−) at the cathode‐sulfide interface impedes fast Li‐ion transfer, which accounts for sluggish reaction kinetics and significant loss of cathode capacity. Herein, we proposed an easily scalable approach to stabilize the cathode electrochemistry via coating the cathode particles by a uniform, Li+‐conductive plastic‐crystal electrolyte nanolayer on their surface. The electrolyte, which simply consists of succinonitrile and Li bis(trifluoromethanesulphonyl)imide, serves as an interfacial buffer to effectively suppress the adverse phase transition in highly delithiated cathode materials, and the loss of lattice oxygen and generation of inactive oxygenated by‐products at the cathode‐sulfide interface. Consequently, an all‐solid‐state rechargeable Li battery with the modified cathode delivers high specific capacities of 168 mAh g−1 at 0.1 C and a high capacity retention >80 % after 100 cycles. Our work sheds new light on rational design of electrode‐electrolyte interface for the next‐generation high‐energy batteries.
Reactive power management in variable frequency transformer (VFT)‐integrated multi‐machine power systems: A STATCOM‐based approach
Authors: Sheikh Aabid Hussain , Bakhsh Farhad Ilahi
Published: June 2024

In order to improve power system stability and suppress low power oscillations, active power regulation using variable frequency transformer (VFT) plays an important role. The literature has already documented in‐depth research on active power transfer control principles of VFT. The VFT, which is basically a wound rotor induction machine consumes reactive power because of magnetizing winding. In terms of the power flow interchange in a two‐area power system incorporating VFT, this work gives an extensive analysis to comprehend the reactive power needs under various operating circumstances. In the context of reactive power compensation, the present study explores two distinct methodologies: the implementation of a fixed shunt capacitor and the utilization of an artificial neural network (ANN)‐based static synchronous compensator (STATCOM). The STATCOM‐based control technique outperforms the conventional fixed shunt capacitor by demonstrating improved capabilities in reducing reactive power imbalances and stabilizing the power system. Further, a control scheme based on voltage regulation is implemented for integrating the STATCOM to enhance the fault ride through capability of a three‐phase bus fault. Additionally, two‐area test system is exposed to a reactive load shift to evaluate the operation of STATCOM, which restores the bus voltage to its pre‐specified value.
Impacts of molecular drivers in aortic dissection
Authors: Tian Cuihong , Chen Yequn , Tan Xuerui
Published: June 2024

Background

Aortic dissection (AD) is a lethal cardiovascular emergency involving high mortality and disability. However, its specific pathogenesis remains to be elucidated.

Methods

A bibliometric analysis based on the Web of Science database, VOSviewer software and Citex platforms was conducted to have a knowledge of the development trends, frontiers and hot spots of AD. Subsequently, the top five AD‐related genes from the titles and abstracts of published literature were searched. Lastly, the roles of the top five genes and their encoded proteins in the onset of AD were reviewed.

Results

The bibliometrics showed that most studies are exploring the molecular drivers related to AD, especially gene mutations. The top five AD‐related genes were transforming growth factor‐β (TGFB)‐related genes, elastin (ELN), fibrillin‐1 (FBN1), angiotensinogen (AGT) and matrix metalloproteinase 9 (MMP9). In particular, regulation of the structure of elastic fiber by TGFB‐related genes, ELN and FBN1, appears to be the principal mechanism contributing to AD onset. Activation of the renin‐angiotensin system is the principal mechanism by which AGT triggers AD. MMP9 promotes the formation and development of AD by degrading extracellular matrix components.

Conclusion

TGFB, ELN, FBN1, AGT and MMP9 are the five top molecular drivers of AD, providing a comprehensive mechanistic insight into AD.
From One's Heart to the Mind of Others: A Study in School‐Aged Children
Authors: Zammuto Marta , Ottaviani Cristina , Bianchi Dora , Laghi Fiorenzo , Lonigro Antonia
Published: June 2024

Studies have shown a significant association between effective parasympathetic modulation of the heart and processes linked to social cognition. Particularly, Quintana and colleagues documented a relation between vagally‐mediated heart rate variability (vmHRV) and performance on a theory of mind (ToM) task, namely, the Reading the Mind in the Eyes Test (RMET), in a sample of university students. The purpose of the present study was to test whether such result would extend to a sample of school‐aged children (7–9 years old) using the child version of the RMET. In addition, the Eyes Test Revised was administered as it is more suitable to evaluate ToM during childhood. Results supported the positive association between vmHRV and ToM abilities, replicating and extending previous results obtained in young adults. The current study adds to the existing literature pointing to HRV as a putative biomarker of social cognition abilities.
Associations of Household and Neighborhood Contexts and Hair Cortisol Among Mexican‐Origin Adolescents From Low‐Income Immigrant Families
Authors: Ip Ka I , Wen Wen , Sim Lester , Chen Shanting , Kim Su Yeong
Published: June 2024

Although neighborhood contexts serve as upstream determinants of health, it remains unclear how these contexts “get under the skin” of Mexican‐origin youth, who are disproportionately concentrated in highly disadvantaged yet co‐ethnic neighborhoods. The current study examines the associations between household and neighborhood socioeconomic status (SES), neighborhood racial–ethnic and immigrant composition, and hair cortisol concentration (HCC)—a physiological index of chronic stress response—among Mexican‐origin adolescents from low‐income immigrant families in the United States. A total of 297 (54.20% female; mage = 17.61, SD = 0.93) Mexican‐origin adolescents had their hair cortisol collected, and their residential addresses were geocoded and merged with the American Community Survey. Neighborhoods with higher Hispanic‐origin and foreign‐born residents were associated with higher neighborhood disadvantage, whereas neighborhoods with higher non‐Hispanic White and domestic‐born residents were associated with higher neighborhood affluence. Mexican‐origin adolescents living in neighborhoods with a higher proportion of Hispanic‐origin residents showed lower levels of HCC, consistent with the role of the ethnic enclave. In contrast, adolescents living in more affluent neighborhoods showed higher levels of HCC, possibly reflecting a physiological toll. No association was found between household SES and HCC. Our findings underscore the importance of taking sociocultural contexts and person–environment fit into consideration when understanding how neighborhoods influence adolescents’ stress physiology.
Rare bird forecast: A combined approach using a long‐term dataset of an Arctic seabird and a numerical weather prediction model
Authors: Senzaki Masayuki , Tamura Kenta , Watanabe Yoshiaki , Watanabe Megumi , Sato Tomonori
Published: June 2024

Wildlife observation is a popular activity, and sightings of rare or difficult‐to‐find animals are often highly desired. However, predicting the sighting probabilities of these animals is a challenge for many observers, and it may only be possible by limited experts with intimate knowledge and skills. To tackle this difficulty, we developed user‐friendly forecast systems of the daily observation probabilities of a rare Arctic seabird (Ross's Gull Rhodostethia rosea) in a coastal area in northern Japan. Using a dataset gathered during 16 successive winters, we applied a machine learning technique of self‐organizing maps and explored how days with gull sightings were related to the meteorological pressure patterns over the Sea of Okhotsk (Method A). We also built a regression model that explains the relationship between gull sightings and local‐scale environmental factors (Method B). We then applied these methods with the operational global numerical weather prediction model (a computer simulation application about the fluid dynamics of Earth's atmosphere) to forecast the daily observation probabilities of our target. Method A demonstrated a strong dependence of gull sightings on the 16 representative weather patterns and forecasted stepwise observation probabilities ranging from 0% to 85.7%. Method B also showed that the strength of the northerly wind and the advancement of the season explained gull sightings and forecasted continuous observation probabilities ranging from 0% to 95.5%. Applying these two methods with the operational global numerical weather prediction model successfully forecasted the varied observation probabilities of Ross's Gull from 1 to 5 days ahead from November to February. A 2‐year follow‐up observation also validated both forecast systems to be effective for successful observation, especially when both systems forecasted higher observation probabilities. The developed forecast systems would therefore allow cost‐effective animal observation and may facilitate a better experience for a variety of wildlife observers.
Long‐term data reveal fitness costs of anthropogenic prey depletion for a subordinate competitor, the African wild dog (Lycaon pictus)
Authors: Reyes de Merkle Johnathan , Creel Scott , Becker Matthew S. , Goodheart Ben , Mweetwa Thandiwe , Mwape Henry , Dröge Egil , Simpamba Twakundine
Published: June 2024

Within carnivore guilds, dominant competitors (e.g., lions, Panthera leo) are limited primarily by the density of prey, while subordinate competitors (e.g., African wild dogs, Lycaon pictus) have been limited by the density of dominant competitors. Historically, the fitness and population density of subordinate competitors have not been tightly linked to prey density. However, populations of large herbivores have declined substantially across sub‐Saharan Africa due to human impacts, and where prey depletion is severe, fitness costs for competitive subordinates may begin to outweigh the benefits of competitive release. Using long‐term intensive monitoring of African wild dogs in Zambia's Luangwa Valley Ecosystem (LVE), we tested the effects of prey depletion on survival and reproduction. We hypothesized that African wild dog fitness would be lower in prey‐depleted areas, despite lower lion densities. Our study area included four contiguous regions that varied in protection level, prey density, and lion density. We fit Bayesian Cormack–Jolly–Seber and closed‐capture models to estimate effects on survival and population density, and generalized linear models to estimate effects on reproductive success. We found that the LVE is a stronghold for African wild dogs, with an estimated median density of 4.0 individuals/100 km2. Despite this high density, survival and reproduction differed among regions, and both components of fitness were substantially reduced in the region with the lowest prey density. Anthropogenic prey depletion is becoming an important limiting factor for African wild dogs. If prey depletion (or any other form of habitat degradation) becomes severe enough that its fitness costs outweigh the benefits of competitive release, such changes can fundamentally alter the balance between limiting factors for competitively subordinate species.
Modelling reindeer rut activity using on‐animal acoustic recorders and machine learning
Authors: Boucher Alexander J. , Weladji Robert B. , Holand Øystein , Kumpula Jouko
Published: June 2024

For decades, researchers have employed sound to study the biology of wildlife, with the aim to better understand their ecology and behaviour. By utilizing on‐animal recorders to capture audio from freely moving animals, scientists can decipher the vocalizations and glean insights into their behaviour and ecosystem dynamics through advanced signal processing. However, the laborious task of sorting through extensive audio recordings has been a major bottleneck. To expedite this process, researchers have turned to machine learning techniques, specifically neural networks, to streamline the analysis of data. Nevertheless, much of the existing research has focused predominantly on stationary recording devices, overlooking the potential benefits of employing on‐animal recorders in conjunction with machine learning. To showcase the synergy of on‐animal recorders and machine learning, we conducted a study at the Kutuharju research station in Kaamanen, Finland, where the vocalizations of rutting reindeer were recorded during their mating season. By attaching recorders to seven male reindeer during the rutting periods of 2019 and 2020, we trained convolutional neural networks to distinguish reindeer grunts with a 95% accuracy rate. This high level of accuracy allowed us to examine the reindeers' grunting behaviour, revealing patterns indicating that older, heavier males vocalized more compared to their younger, lighter counterparts. The success of this study underscores the potential of on‐animal acoustic recorders coupled with machine learning techniques as powerful tools for wildlife research, hinting at their broader applications with further advancement and optimization.
Genetic diversity and population structure of a rare flowering tree endemic to Appalachia, Stewartia ovata
Authors: Yadav L. K. , Bellis D. , Smith Z. C. , Ony M. , Hale C. , Richards C. , Klingeman W. E. , Staton M. E. , Granger J. J. , Hadziabdic D.
Published: June 2024

Stewartia ovata (cav.) Weatherby, commonly known as mountain stewartia, is an understory tree native to the southeastern United States (U.S.). This relatively rare species occurs in isolated populations in Virginia, Kentucky, Tennessee, North Carolina, South Carolina, Georgia, Alabama, and Mississippi. As a species, S. ovata has largely been overlooked, and limited information is available regarding its ecology, which presents obstacles to conservation efforts. Stewartia ovata has vibrant, large white flowers that bloom in summer with a variety of filament colors, suggesting potential horticultural traits prized by ornamental industry. However, S. ovata is relatively slow growing and, due to long seed dormancy, propagation is challenging with limited success rates. This has created a need to assess the present genetic diversity in S. ovata populations to inform potential conservation and restoration of the species. Here, we employ a genotyping‐by‐sequencing (GBS) approach to characterize the spatial distribution and genetic diversity of S. ovata in the southern Appalachia region of the eastern United States. A total of 4475 single nucleotide polymorphisms (SNPs) were identified across 147 individuals from 11 collection sites. Our results indicate low genetic diversity (He = 0.216), the presence of population structure (K = 2), limited differentiation (FST = 0.039), and high gene flow (Nm = 6.16) between our subpopulations. Principal component analysis corroborated the findings of STRUCTURE, confirming the presence of two distinct S. ovata subpopulations. One subpopulation mainly contains genotypes from the Cumberland Plateau, Tennessee, while the other consists of genotypes present in the Great Smoky Mountain ranges in Tennessee, North Carolina, and portions of Nantahala, Chattahoochee‐Oconee national forests in Georgia, highlighting that elevation likely plays a major role in its distribution. Our results further suggested low inbreeding coefficient (FIS = 0.070), which is expected with an outcrossing tree species. This research further provides necessary insight into extant subpopulations and has generated valuable resources needed for conservation efforts of S. ovata.
Wall‐following – Phylogenetic context of an enhanced behaviour in stygomorphic Sinocyclocheilus (Cypriniformes: Cyprinidae) cavefishes
Authors: Chen Bing , Dai Wen‐Zhang , Li Xiang‐Lin , Mao Ting‐Ru , Liu Ye‐Wei , Pie Marcio R. , Yang Jian , Meegaskumbura Madhava
Published: June 2024

With 75 known species, the freshwater fish genus Sinocyclocheilus is the largest cavefish radiation in the world and shows multiple adaptations for cave‐dwelling (stygomorphic adaptations), which include a range of traits such as eye degeneration (normal‐eyed, micro‐eyed and eyeless), depigmentation of skin, and in some species, the presence of “horns”. Their behavioural adaptations to subterranean environments, however, are poorly understood. Wall‐following (WF) behaviour, where an organism remains in close contact with the boundary demarcating its habitat when in the dark, is a peculiar behaviour observed in a wide range of animals and is enhanced in cave dwellers. Hence, we hypothesise that wall‐following is also present in Sinocyclocheilus, possibly enhanced in eyeless species compared to eye bearing (normal‐/micro‐eyed species). Using 13 species representative of Sinocyclocheilus radiation and eye morphs, we designed a series of assays, based on pre‐existing methods for Astyanax mexicanus behavioural experiments, to examine wall‐following behaviour under three conditions. Our results indicate that eyeless species exhibit significantly enhanced intensities of WF compared to normal‐eyed species, with micro‐eyed forms demonstrating intermediate intensities in the WF distance. Using a mtDNA based dated phylogeny (chronogram with four clades A–D), we traced the degree of WF of these forms to outline common patterns. We show that the intensity of WF behaviour is higher in the subterranean clades compared to clades dominated by normal‐eyed free‐living species. We also found that eyeless species are highly sensitive to vibrations, whereas normal‐eyed species are the least sensitive. Since WF behaviour is presented to some degree in all Sinocyclocheilus species, and given that these fishes evolved in the late Miocene, we identify this behaviour as being ancestral with WF enhancement related to cave occupation. Results from this diversification‐scale study of cavefish behaviour suggest that enhanced wall‐following behaviour may be a convergent trait across all stygomorphic lineages.
Predation can shape the cascade interplay between heterothermy, exploration and maintenance metabolism under high food availability
Authors: Boratyński Jan S. , Iwińska Karolina , Wirowska Martyna , Borowski Zbigniew , Zub Karol
Published: June 2024

Maintenance metabolism as the minimum energy expenditure needed to maintain homeothermy (a high and stable body temperature, Tb), reflects the magnitude of metabolic machinery and the associated costs of self‐maintenance in endotherms (organisms able to produce heat endogenously). Therefore, it can interact with most, if not all, organismal functions, including the behavior–fitness linkage. Many endothermic animals can avoid the costs of maintaining homeothermy and temporally reduce Tb and metabolism by entering heterothermic states like torpor, the most effective energy‐saving strategy. Variations in BMR, behavior, and torpor use are considered to be shaped by food resources, but those conclusions are based on research studying these traits in isolation. We tested the effect of ecological contexts (food availability and predation risk) on the interplay between the maintenance costs of homeothermy, heterothermy, and exploration in a wild mammal—the yellow‐necked mouse. We measured maintenance metabolism as basal metabolic rate (BMR) using respirometry, distance moved (exploration) in the open‐field test, and variation in Tb (heterothermy) during short‐term fasting in animals captured at different locations of known natural food availability and predator presence, and with or without supplementary food resources. We found that in winter, heterothermy and exploration (but not BMR) negatively correlated with natural food availability (determined in autumn). Supplementary feeding increased mouse density, predation risk and finally had a positive effect on heterothermy (but not on BMR or exploration). The path analysis testing plausible causal relationships between the studied traits indicated that elevated predation risk increased heterothermy, which in turn negatively affected exploration, which positively correlated with BMR. Our study indicates that adaptive heterothermy is a compensation strategy for balancing the energy budget in endothermic animals experiencing low natural food availability. This study also suggests that under environmental challenges like increased predation risk, the use of an effective energy‐saving strategy predicts behavioral expression better than self‐maintenance costs under homeothermy.
Effects of short‐term exposure to Pomacea canaliculata secretions on Limnodrilus hoffmeisteri and Propsilocerus akamusi: A study based on behavior, intestinal microbiota, and antioxidant system
Authors: Liu Mingyuan , Sui Changrun , Wang Baolong , Huang Ruipin , Zhang Weixiao , Zhang Tao , Zhang Qian , Liu Ying
Published: June 2024

Pomacea canaliculata is one of the most notorious invasive aquatic snail, capable of influencing various aquatic organisms through their secretions. Limnodrilus hoffmeisteri and Propsilocerus akamusi are the most prevalent and powerful bioturbators in aquatic ecosystems. However, the mechanism of P. canaliculata's secretions affecting bioturbators remains unknown. This study aimed to investigate the effects of P. canaliculata's secretion on L. hoffmeisteri and P. akamusi. L. hoffmeisteri and P. akamusi were treated for 24 h with P. canaliculata and the native species Bellamya aeruginosa secretions at different densities (1 or 20). The migration numbers and aggregation rate of L. hoffmeisteri indicated that P. canaliculata secretion caused L. hoffmeisteri to become alert and migrate away from the nucleus community, resulting in poor population identification, especially at high concentrations. Moreover, the antioxidant enzymatic activity, lipid peroxidation, intestinal microbial diversity, and composition of the two bioturbators were analyzed. Superoxide dismutase (SOD) activity and malondialdehyde (MDA) concentration were elevated following P. canaliculata secretion treatment, indicating oxidative damage. Furthermore, the composition and diversity of intestinal microbiota of L. hoffmeisteri and P. akamusi were changed. The abundance of functional microbiota decreased, and pathogenic bacteria such as Aeromonas became dominant in the intestines of both bioturbators. The current research evaluates the effects of P. canaliculata secretion on the behavior, oxidative stress, and intestinal microbial composition and diversity of two bioturbators, providing new insights into the assessment of post‐invaded ecosystems.
Mite non‐reproduction is not a consequence of the brood removal behavior of varroa sensitive hygiene honey bee colonies (Apis mellifera)
Authors: Sprau Lina , Traynor Kirsten , Gessler Birgit , Hasselmann Martin , Rosenkranz Peter
Published: June 2024

A sustainable solution to the global threat of the Varroa destructor mite is the selection of varroa‐resistant honey bee (Apis mellifera) colonies. Both “mite non‐reproduction” (MNR) and “varroa sensitive hygiene” (VSH) appear to be promising selection traits for achieving the goal of a resistant honey bee. MNR describes colonies that have a high number of non‐reproductive mites (no offspring, no males, or delayed development of mite offspring). High numbers of non‐reproductive mites have been observed in selected colonies, but the mechanism behind this trait has not yet been identified. The specialized hygienic behavior of selected honey bees, called VSH, is the removal of varroa‐infested brood. These traits were thought to be linked by VSH bees preferentially removing reproductive varroa females leaving only non‐reproductive mites behind in cells and thus creating colonies with high levels of MNR. To further investigate this link, we used an experimental setup and data sets from a four‐year selection project designed to breed for MNR and VSH colonies. In addition, we sought to answer the question of whether non‐reproductive mites are a direct consequence of worker removal behavior. To test this, we artificially induced removal behavior, and after providing the mite with enough time to re‐enter another cell, we opened all capped cells, relocated the mites, and evaluated their reproduction. As shown in previous studies and in this study, VSH had no effect on MNR levels. Also, the induced removal behavior did not lead to non‐reproduction in the subsequent reproductive cycle post interruption. We thus concluded that breeding for non‐reproductive mites does not automatically breed for VSH behavior and worker removal behavior does not cause subsequent reproductive failure of the mites forced to flee and find a new cell for reproduction.
PhyloJS: Bridging phylogenetics and web development with a JavaScript utility library
Authors: Featherstone Leo A. , Wirth Wytamma
Published: June 2024

There is an increasing number of libraries devoted to parsing, manipulating and visualising phylogenetic trees in JavaScript. Many of these libraries bundle tree manipulation with visualisation, but have limited ability to manipulate trees and lack detailed documentation. As the number of web‐based phylogenetic tools and the size of phylogenetics datasets increases, there is a need for a library that parses, writes and manipulates phylogenetic trees that is interoperable with other phylogenetic and data visualisation libraries. Here we introduce PhyloJS, a light zero‐dependency TypeScript and JavaScript library for reading, writing and manipulating phylogenetic trees. PhyloJS allows for modification of and data‐extraction from trees to integrate with other phylogenetics and data visualisation libraries. It can swiftly handle large trees, up to at least 106 tips in size, making it ideal for developing the next generation of more complex web‐based phylogenetics applications handling ever larger datasets. The PhyloJS source code is available on GitHub (https://github.com/clockor2/phylojs) and can be installed via npm with the command npm install phylojs. Extensive documentation is available at https://clockor2.github.io/phylojs/.
Post‐Functionalization of Organoboranes by Cu‐Catalyzed Azide Alkyne [3+2]‐Cycloaddition Reaction
Authors: Bonnard Mélanie , Pinet Sandra , Chabaud Laurent , Pucheault Mathieu
Published: June 2024

The copper‐catalyzed azide alkyne [3+2]‐cycloaddition (CuAAC) reaction of organoboranes represents an attractive area of research within the field of click chemistry, with diverse applications in organic synthesis, medicinal chemistry, or materials science. Despite the potential issues caused by the copper insertion into the carbon‐boron bond, significant progress has been made to harness the reactivity of organoboron compounds in CuAAC. This review provides an overview of the catalytic methods reported for CuAAC with various organoboranes, discussing the stability of the boron group and highlighting recent advancements in this area.
The true self in reflections? Visual self‐recognition and the Big Five
Authors: Stephan Elena , Walker Mirella
Published: June 2024

Typically, individuals are motivated to see themselves in a flattering light regarding their physical and personality characteristics. We suggest that visual self‐perception is anchored in the true self which is largely the self‐enhancing self, and may also reflect the privileged access to one's traits and internal states. Here, we examine the impact and limits of self‐enhancement motivation and egocentric bias on individuals’ recognition of variations of their portraits in terms of the Big Five personality dimensions. We predict that individuals recognise themselves better in positively altered portraits, namely, portraits looking more agreeable, conscientious and open. We also predict that self‐enhancement is anchored in reality: Individuals recognise themselves less in strongly altered than in slightly or non‐altered portraits. In Study 1, we measure the directions of self‐recognition distortions by investigating in which random variations of their portraits individuals recognise themselves. In Study 2, relying on a mouse tracking paradigm, we additionally measure the degree of distortion, and the conflict individuals experience during the self‐recognition task. Results of both studies mainly demonstrate self‐recognition distortions towards agreeableness, conscientiousness, openness and neuroticism. Moreover, results from Study 2 reveal that self‐recognition is anchored in reality. Findings of two studies applying different methods convergently show systematic biases in self‐recognition regarding the Big Five dimensions, both enriching understanding of the self‐enhancement processes and demonstrating that the methods applied might be useful for future research focusing on self‐recognition.
Response to a comment on: Rates and correlates of study enrolment and use of a chatbot aimed to promote mental health services use for eating disorders following online screening
Authors: D’Adamo Laura , Grammer Anne Claire , Rackoff Gavin N. , Shah Jillian , Firebaugh Marie‐Laure , Taylor C. Barr , Wilfley Denise E. , Fitzsimmons‐Craft Ellen E.
Published: June 2024

Highlights

In response to a comment on our recent article, this paper highlights that the goal of our chatbot was to reach individuals with eating disorders who are not engaged with traditional mental health services using a scalable digital screening and intervention approach.

We describe our rationale for the lack of clinical assessments in our study, namely, the importance of conducting digital mental health research under real‐world conditions and the need to reduce barriers to research participation for individuals in need of treatment for eating disorders.

We emphasise the substantial public health impact that a chatbot, like the one we developed and evaluated, could have for increasing treatment‐seeking and uptake among adults with eating disorders and encourage researchers to consider study designs that are conducted under real‐world conditions.
Effect of different reperfusion strategies on recovery of ventricular function after ST‐segment elevation myocardial infarction: A longitudinal single‐center study
Authors: Attar Armin , Namvar Soheila , Hosseinpour Alireza , Azami Pouria , Shekari Arash , Jamali Leila , Goudarzi Neda
Published: June 2024

Background and Aims

Although the clinical benefit of percutaneous coronary intervention (PCI) on cardiovascular outcomes has been widely investigated, the impact of this revascularization strategy compared to other alternatives on the degree of left ventricular function recovery is poorly demonstrated. In this regard, we investigated whether time delays between the presentation of ST‐segment elevation myocardial infarction (STEMI) and PCI in reperfusion strategies have different impacts on left ventricular function recovery.

Methods

In this single‐center study, all the patients who presented with STEMI and a reduced left ventricular ejection fraction (LVEF ≤ 40%) were enrolled. Included patients were subjected to four different treatment groups of primary, rescue (immediate transfer for angioplasty due to failed fibrinolytic therapy), facilitated (fibrinolytic therapy followed by angioplasty within 24 h), and deferred (successful fibrinolytic therapy and PCI after 24 h) PCI based on hospital facilities. Echocardiography was performed for all the patients at the time of hospitalization and 6 months later.

Results

A total of 128 patients were included in this study. The LVEF improved by 15.3 ± 6.3%, 11.5 ± 3.61%, 4.0 ± 1.0%, and −1.3 ± 7.0% in primary, rescue, facilitated, and deferred PCI groups, respectively (p < 0.001). Patients undergoing deferred PCI experienced a significantly lower improvement in LVEF compared with primary and rescue PCI (p < 0.001).

Conclusion

Primary PCI demonstrated the most promising recovery in left ventricular function following STEMI compared to other alternative strategies. Performing PCI as soon as possible provides better recovery of LVEF.
Reasons of sprinkler freezing and rotational irrigation for frost protection in tea plantations
Authors: Pan Qingmin , Hu Yongguang
Published: June 2024

Sprinkler irrigation can effectively reduce the rate of frostbite on cash crop buds and young fruits. In this study, we propose applying the rotational irrigation method in frost protection to achieve water conservation, simplify the sprinkler system and expand the frost protection area. The freezing test of various sprinklers in a frosty environment (approximately −4.0°C) was conducted to determine the maximum duration of sprinkling cessation for the microsprinkler, butterfly‐shaped sprinkler, impact sprinkler and MegaNet sprinkler. The results indicate that the butterfly‐shaped sprinkler and impact sprinkler freeze after 4 and 3 min, respectively. In contrast, the microsprinkler and MegaNet sprinkler do not freeze even after 10.0 min. The temperature increase amplitude and rate of the microsprinkler are significantly greater. At an ambient temperature of −4.0°C, three areas were irrigated with microsprinklers. Each sprinkler had a rotation interval of 3.0 min of spraying followed by 6.0 min of stopping. This ensured that the canopy temperature was maintained at approximately −1.0°C. The water consumption was only one‐third of that used in continuous sprinkler irrigation. This sprinkler irrigation method for frost protection is more water efficient than traditional continuous sprinkler irrigation and easier to operate and maintain than existing automatic sprinkler irrigation methods.
Cross‐sectional evaluation of a clinical decision support tool to identify medication‐related problems at discharge from the acute care setting
Authors: DiCristina Savanna , Turgeon Jacques , Michaud Veronique , Brunetti Luigi
Published: June 2024

Background

There are many reported pharmacist‐led transitions of care (TOC) programs to address medication‐related problems (MRP) at discharge from the acute care setting. Most have identified time and labor resources as significant limitations. This study aims to assess the effectiveness of a medication risk score (MRS)‐driven clinical decision support system (CDSS) in identifying actionable MRPs and improving medication safety in the acute care discharge TOC setting.

Methods

A cross‐sectional analysis was conducted in a cohort of 481 subjects discharged from the acute care setting. The MRS‐CDSS was utilized to identify MRPs and provide recommendations for risk reduction. The distribution of MRPs, recommendations, and their associations with MRS severity were analyzed. Additionally, the potential reduction in MRS per subject and its correlation with MRS severity were examined.

Results

The median MRS reduction per subject was 2 points, while high/severe‐risk patients showed a median potential reduction of 7 points. Among the identified MRPs (n = 691), drug interaction, drug use without indication, and adverse drug reaction accounted for 89.7% of all MRPs. The top three recommendations, discontinue medication, change the time of administration, and start alternative therapy, represented 94.1% of all recommendations. Stratified analysis by MRS category revealed a significant increase in adverse drug reaction MRPs and recommendations to discontinue medications with higher MRS severity. The results were consistent with previous outpatient studies, supporting the MRS‐CDSS's ability to enhance medication safety.

Conclusion

This study demonstrates that the MRS‐CDSS effectively identifies actionable MRPs and has the potential to substantially reduce overall pharmacotherapy regimen risk when applied during acute care discharge TOC. The findings support implementable recommendations directed at patient safety and the allocation of health care resources to high‐risk patients for maximum benefit.
Neuroimmune response and oxidative stress in the prefrontal cortex mediate seizure susceptibility in experimental colitis in male mice
Authors: Moradipoor Fahimeh , Jivad Nahid , Asgharzadeh Samira , Zare Ehsan , Amini‐Khoei Hossein
Published: June 2024

Inflammatory bowel disease (IBD) is a chronic gastrointestinal disorder. Oxidative stress and inflammatory responses have a vital role in the pathophysiology of IBD as well as seizure. IBD is associated with extraintestinal manifestations. This study aimed to explore the relationship between colitis and susceptibility to seizures, with a focus on the roles of neuroinflammation and oxidative stress in acetic acid‐induced colitis in mice. Forty male Naval Medical Research Institute mice were divided into four groups: control, colitis, pentylenetetrazole (PTZ), and colitis + PTZ. Colitis was induced by intrarectal administration of acetic acid, and seizures were induced by intravenous injection of PTZ 7 days postcolitis induction. Following the measurement of latency to seizure, the mice were killed, and their colons and prefrontal cortex (PFC) were dissected. Gene expression of inflammatory markers including interleukin‐1β, tumor necrosis factor‐alpha, NOD‐like receptor protein 3, and toll‐like receptor 4, as well as total antioxidant capacity (TAC), malondialdehyde (MDA), and nitrite levels were measured in the colon and PFC. Histopathological evaluations were performed on the colon samples. Data were analyzed by t‐test or one‐way variance analysis. Colitis decreased latency to seizure, increased gene expression of inflammatory markers, and altered levels of MDA, nitrite, and TAC in both the colon and PFC. Simultaneous induction of colitis and seizure exacerbated the neuroimmune response and oxidative stress in the PFC and colon. Results concluded that neuroinflammation and oxidative stress in the PFC at least partially mediate the comorbid decrease in seizure latency in mice with colitis.
Seed morphology of 31 EuphorbiaL. species (Euphorbiaceae) in Turkey and their taxonomic significance
Authors: Patterson Aysun , Karaismailoğlu Mehmet Cengiz , Küçüker Orhan
Published: June 2024

This paper includes a comprehensive taxonomical study based on seed morphology of 31 Euphorbia L species from Türkiye. The studied Euphorbia taxa have been examined for morphological traits such as seed color, dimensions, surface ornamentation, cell wall structures, lipid granule presence, and caruncle shape and dimensions with Scanning electron microscopy (SEM) and stereo microscopy to develop a better understanding of the basis of its species. The outcomes show that the species differ based on seed shape and color. The seed width dimensions are between 0.55 and 3.83 mm and the length dimensions are between 1.03 and 5.87 mm. Euphorbia lathyris, E. prostrata, and E. nutans are marked differently from the rest of the studied species based on their seed dimension. The seed surface ornamentation is classified into 12 different types: tuberculate, reticulate, areolate, colliculate, verrucate, alveolate, rugose, alveolate‐reticulate, slightly reticulate, reticulate‐areolate, pusticulate, and ruminate. The most common form is reticulate, found in eight species. The tuberculate (in E. helioscopia), areolate (in E. oblongata), slightly reticulate (in E. amygdaloides), and ruminate (in E. herniariifolia) ornamentation types are each characterized by only one species. The presence of lipid granules and anticlinal and periclinal cell walls disclose interspecific relationships within the examined taxa. Also, an identification key is offered for the studied species based on seed characters.

Research Highlights

The seeds of Turkish Euphorbia species have been studied in depth.

The morphological characters of seeds of Turkish Euphorbia species have been examined utilizing SEM and light microscopy for the first time and discussed the taxonomic practice of these characteristics.

A dichotomous key containing seed morphological data has presented.
Binding characteristics of the doxepin E/Z‐isomers to the histamine H1 receptor revealed by receptor‐bound ligand analysis and molecular dynamics study
Authors: Kaneko Hiroto , Korenaga Ryunosuke , Nakamura Ryota , Kawai Shinnosuke , Ando Tadashi , Shiroishi Mitsunori
Published: June 2024

Doxepin is an antihistamine and tricyclic antidepressant that binds to the histamine H1 receptor (H1R) with high affinity. Doxepin is an 85:15 mixture of the E‐ and Z‐isomers. The Z‐isomer is well known to be more effective than the E‐isomer, whereas based on the crystal structure of the H1R/doxepin complex, the hydroxyl group of Thr1123.37 is close enough to form a hydrogen bond with the oxygen atom of the E‐isomer. The detailed binding characteristics and reasons for the differences remain unclear. In this study, we analyzed doxepin isomers bound to the receptor following extraction from a purified H1R protein complexed with doxepin. The ratio of the E‐ and Z‐isomers bound to wild‐type (WT) H1R was 55:45, indicating that the Z‐isomer was bound to WT H1R with an approximately 5.2‐fold higher affinity than the E‐isomer. For the T1123.37V mutant, the E/Z ratio was 89:11, indicating that both isomers have similar affinities. Free energy calculations using molecular dynamics (MD) simulations also reproduced the experimental results of the relative binding free energy differences between the isomers for WT and T1123.37V. Furthermore, MD simulations revealed that the hydroxyl group of T1123.37 did not form hydrogen bonds with the E‐isomer, but with the adjacent residues in the binding pocket. Analysis of the receptor‐bound doxepin and MD simulations suggested that the hydroxyl group of T1123.37 contributes to the formation of a chemical environment in the binding pocket, which is slightly more favorable for the Z‐isomer without hydrogen bonding with doxepin.
Associations between hospital‐level socioeconomic patient mix and rates of central line–associated bloodstream infections in short bowel syndrome: A retrospective cohort study
Authors: Gutierrez Susan A. , Chiou Sy Han , Raghu Vikram , Cole Conrad R. , Rhee Sue , Lai Jennifer C. , Wadhwani Sharad I.
Published: June 2024

Background

Low neighborhood income is linked with increased hospitalizations for central line–associated bloodstream infections (CLABSIs) in pediatric short bowel syndrome (SBS). We assessed whether this relationship varies by hospital center.

Methods

We performed a retrospective cohort study using the Pediatric Health Information System (2018–2023) database for patients <18 years old with SBS (N = 1210) at 24 hospitals in the United States. Using 2015 US Census data, we determined the estimated median household income of each patient's zip code. Hospital‐level neighborhood income was defined as the median of the estimated median household income among patients at each hospital. We applied an extension of Cox regression to assess risk for CLABSI hospitalization.

Results

Among 1210 children with 5255 hospitalizations, most were <1 year on initial admission (53%), male (58%), and publicly insured (69%). Hospitals serving low‐income neighborhoods served more female (46% vs 39%), Black (29% vs 22%), and Hispanic (22% vs 16%) patients with public insurance (72% vs 65%) residing in the southern United States (47% vs 21%). In univariate analysis, low hospital‐level neighborhood income was associated with increased risk of CLABSI hospitalization (rate ratio [RR], 1.48; 95% CI, 1.21–1.83; P < 0.001). These findings persisted in multivariate analysis (RR, 1.43; 95% CI, 1.10–1.84; P < 0.01) after adjusting for race, ethnicity, insurance, region, and patient‐level neighborhood income.

Conclusion

Hospitals serving predominantly low‐income neighborhoods bear a heavier burden of CLABSI hospitalizations for all their patients across the socioeconomic spectrum. Hospital initiatives focused on CLABSI prevention may be pivotal in addressing this disparity.
Comprehensive assessment of combined inorganic and organic fertilization strategies on cotton cultivation: implications for sustainable agriculture
Authors: Lin Shudong , Wang Quanjiu , Wei Kai , Zhao Xue , Tao Wanghai , Sun Yan , Su Lijun , Deng Mingjiang
Published: June 2024

BACKGROUND

The integration of inorganic and organic fertilizers is increasingly being recommended to address the demand for sustainable cotton cultivation and to mitigate the ecological impacts of reliance on inorganic fertilizers. However, the nuanced effects of this combined fertilization approach on soil quality, cotton growth, yield, and their interaction mechanisms, remain unclear.

METHOD

To elucidate this, a 2‐year field trial (2022–2023) was conducted, incorporating five fertilization treatments: low inorganic fertilizer (BI1), high inorganic fertilizer (BI2), organic fertilizer (BO), combined low inorganic and organic fertilizer (BIO1), and combined high inorganic and organic fertilizer (BIO2). This study aimed to evaluate the influence of these treatments on soil quality, cotton growth, and yield.

RESULTS

The results indicate that the BO treatment significantly enhanced plant height growth rate, and BIO1 treatment increased leaf area index and dry matter accumulation growth rate. Critical soil parameters such as alkali‐hydrolyzed nitrogen and available potassium emerged as pivotal determinants of soil quality over the trial period, corresponding to soil quality index (SQI) values of 0.482 and 0.478, and yields of 7506.19 kg ha−1 and 6788.02 kg ha−1, respectively. Water productivity reached optimum levels at SQI values of 0.461 and 0.462, with corresponding efficiencies of 13.31 kg (ha mm)−1 and 12.16 kg (ha mm)−1. Partial least squares path modeling revealed that integrating organic fertilizer with reduced inorganic fertilizer usage significantly boosts cotton yield by enhancing soil quality (path coefficient: 0.842).

CONCLUSION

In conclusion, this integrated fertilization strategy not only improves soil health but also increases agricultural productivity. It presents a promising approach for optimizing crop yields while fostering sustainable agricultural practices. © 2024 Society of Chemical Industry.