bluuebunny/crossref_metadata_2025 huggingface dataset:
Study on Mechanical Properties of Single Fractured Dry Heat Rock Under Uniaxial Compression
Authors: Zhu Dong , Fan Yuqing , Jing Hongwen , Yue Liang , Jin Huiwu , Miao Lei gang
Published: December 2022

Uniaxial compression tests were carried out on single fissure slab granite specimens (size 80 mm×160 mm×30 mm) at 250,350 and 450°C after several (1-20) hot and cold treatments using a rock mechanics servo tester MTS816, acoustic emission meter and high speed digital photography to analyze the effects of temperature and number of treatments on the strength-deformation characteristics and crack evolution of single fissure granite. It was found that the peak strength of the specimens at the three heating temperatures showed a continuous decrease with the increase of the number of treatments, among which, the decrease of the peak strength of the specimens at 250 ℃ was the smallest, the decrease at 450 ℃ was the middle, and the decrease at 350 ℃ was the largest. Based on the analysis of the acoustic emission characteristics during the loading of single fissure slab granite, for each larger acoustic emission event generated, the cumulative acoustic emission appears to increase steeply, and the corresponding rupture of the specimen takes the form of the production of a new crack, crack extension or sheet crack initiation. The crack evolution characteristics of different single-fissure slab granite specimens were analyzed by photogrammetric techniques. Finally, the effects of temperature and number of treatments on the cracking and damage of single fissure slab granite were investigated. The cracking stress and yield strength tended to decrease nonlinearly with increasing temperature, with the greatest decrease after 5 treatments at 250 and 350°C, however, the greatest decrease was reached after 15 treatments at 450°C and the form of damage to the specimen by the prefabricated fracture is influenced both by the temperature and the number of treatments.
An influence of Nano particles of bentonite clay on mechanical properties of ferrous clay composite through additive manufacturing route
Authors: Bhosale Shrikrushna B. , Bhowmik Sumit , Ray Amitava
Published: December 2022

The powder metallurgy (P/M) components have been extensively used in industrial applications and P/M components properties has been influenced by alloying elements and porosity. In the present work, the bentonite clay (aluminum silicate) as porosity filler has been mixed in the ferrous alloy for manufacturing of low porosity P/M components. The specimens have been manufactured by using iron-carbon-copper and iron-carbon-copper-nickel- molybdenum with bentonite clay. The bentonite clay has varied with wt. % of 1–5% at the interval of 1%. To recognize the effect of bentonite clay, the mechanical properties such as density and porosity have measured and the crushing strength, and hardness test has carried out. Also, microstructure analysis has been carried out by optical microstructure study and scanning electron microscopy (SEM). Further the X-ray diffraction (XRD) and Energy Dispersive Spectrometry (EDS) analysis has been carried out for clay particles location and homogeneous mixing. The micro-structure and chemical composition analysis shows that the clay remains at grain boundary. The test results shows that the porosity has significantly reduced while, slightly reduction has been found in density, hardness and crushing strength with an increase in wt. % of clay. This analysis show that the 1% of Nano-particles of bentonite clay is helpful as porosity fillers with acceptable mechanical properties.
Colorectal cancer with germline BRCA1 variant: A case report
Authors: Kim Kyoung Min , Lee Min Ro , Ahn Ae Ri , Chung Myoung Ja
Published: December 2022

Background: Sporadic colorectal cancer (CRC) is the most common form of CRC. However, hereditary CRC is also common. BRCA 1/2 (Breast Cancer Gene, 1 and 2) variants increase the risk for breast and ovarian cancers. CRC has also been associated with BRCA variants, but the relevant risks are not clear. We present a case of rectal cancer with a germline BRCA1 pathogenic variant.
Case Report: A 39-year-old male was admitted to our hospital with rectal carcinoma that had been detected in a local hospital. The patient underwent surgical resection and pathologic diagnosis was adenocarcinoma. Next generation sequencing (NGS) was performed and the BRCA1 variant was detected. Reviewing the public database and considering the young age of the patient, the variant was suggested to be germline. Thereafter, to confirm the variant to be germline, normal tissue was sequenced and the same BRCA1 variation was detected. Moreover, the patient’s father had prostatic cancer and NGS testing revealed the identical BRCA1 variant.
Conclusions: In the BRCA cancer group, there is relatively little attention paid to male cancer compared to female cancer. The accumulation of male BRCA-related CRC reports may contribute to establishing a relationship between the two.
High-resolution anorectal manometry in the diagnosis of moderate rectocele in symptomatic women compared to healthy subjects
Authors: Geng Hong Zhi , Zhang Yi , Xu Chen , Cong Jiying , Li Yuwei
Published: December 2022

BackgroundFew studies have investigated the healthy subject in women (HSW) and moderate rectocele in the symptomatic women (MRSW) identifiedby using three-dimensional high-resolution anorectal manometry(3D HARM) parameters correlate age stratification.ObjectiveClinical diagnostic values were explored between the MRSW and the HSW groups by 3D HARM parameters related to age stratification.MethodsA retrospective cohort study involving 128 cases from the MRSW and HSW groups by using 3D HARM parameters was enrolled at Tianjin Union Medical Center between January 2017 and June 2022.ResultsLinear regression analysis showed that age was an independent risk factor for the prognosis of maximum squeezing pressure in females (P= 0.000). In the HSW group, age was negatively correlated with maximum resting pressure and maximum squeeze pressure in females, (P= 0.029), and (P= 0.001), respectively.Logistic regression analysis showed that age and RAIR were independent factors in the prognosis of MRSW, (P= 0.024), and (P= 0.001), respectively.ConclusionAge and RAIR were independent risk factors for prognosis in the MRSW group compared to the HSW group using 3D HARM, and age was also an independent risk factor for the prognosis of maximum squeezing pressure in women.
Weaning caused imbalanced T lymphocytes distribution and impaired intestinal immune barrier function in piglets
Authors: YU li huai , Dong li , Wang Meng xuan , Peng Zhong , Wang Hongrong , li Hongmin , Qin Tao , Yin Yinyan
Published: December 2022

A total of 40 piglets with similar body weights were selected in pairs at 21 days old and divided into the suckling group (SG: breastfed by their mothers) and weaning group (WG: weaned at 21 days old). Eight piglets from each group were randomly selected and sacrificed at 24 days (SG3 and WG3) and 28 days of age (SG7 and WG7). The growth performance, T lymphocyte subpopulations, the concentration of cytokines and immunoglobulins, and the expression of Notch2 signaling proteins were determined. The weaning caused a decrease in body weight (P < 0.01) and the ratio of CD3+CD4+/CD3+CD8+ T cells in thymus (P < 0.05). Compared to SG3, the concentration of secretory immunoglobulin A (sIgA) in jejunum was decreased, and that of interleukin 2 (IL-2) in serum and ileum, IL-1β and IL-2 in jejunum were upregulated (P < 0.01), while IL-10 in the small intestine was downregulated (P < 0.05) in WG3. Weaning downregulated gene expression of IL-4 and upregulated gene expression of IL-1β, IL-12, and interferon γ (IFN-γ) in small intestine (P < 0.05). Further, weaning downregulated protein expression of Notch2 and Hes1 but upregulated Jagged1 expression in small intestine of piglets (P < 0.05). In summary, weaning caused an imbalance in T lymphocytes distribution, thus impairing the intestinal immune function of piglets, which might be associated with the Notch2 signaling. Furthermore, the impairment of intestinal immune barrier function was more severe at 3 days post-weaning than that at the 7 days post-weaning in piglets.
A nonlinear system dynamics and simulation analysis of fractional order modelling on employees negative attitude towards their workplace with intervention strategies
Authors: Teklu Shewafera Wondimagegnhu , Mamo Dejen Ketema
Published: December 2022

In this paper, we have formulated and analyzed a Caputo fractional order mathematical model with intervention strategies on employees’ negative attitudes towards the workplace. Non-negativity and boundedness of the dynamical system solutions have been analyzed. The existence and stability of negative attitude-free and negative attitude endemic equilibrium points of the Caputo fractional order model were investigated and analyzed. The negative attitude-free equilibrium is local stability. The backward bifurcation of the Caputo fractional order model was conditionally analyzed whenever the effective reproduction number could be less than one. Further, we performed our analytical results through numerical simulations and obtained consistent results. Efficient employee protection and treatment of negative attitudes toward the workplace reduce and potentially removes negative attitudes from the employees.
Exome-wide association study identified genetic variants contributing to the risk of cerebral palsy
Authors: Xing Qinghe , Cheng Ye , Xu Yiran , Li Hongwei , Qiao Yimeng , Wang Yangong , Su Yu , Zhang Jin , Wang Xiaoyang , Zhu Changlian
Published: December 2022

Cerebral palsy (CP) is the most common physical disability in childhood that results from the interaction of environmental and genetic factors. Yet in many patients, the etiology remains unknown. We identified significant association at rs3131787 within the human leukocyte antigen (HLA) region using two-stage association study between 1,090 CP cases and 1,100 controls. Fine mapping of the HLA region indicated that the carrier frequency of HLA-B*13:02 was significantly higher in CP, particularly in CP without preterm birth, low birth weight, birth asphyxia or periventricular leukomalacia (PVL). DRB1*07:01/DQA1*02:01 was also significantly enriched in CP and more specifically in dyskinetic type. Additionally, significant enrichment of carrier frequency was detected for HLA-A*32:01 in CP with either preterm birth or low birth weight and for HLA-B*27:05 in CP with birth asphyxia. These data suggest that immune dysregulation resulting from immunogenetic variants or environmental exposures may underlie the pathogenesis of CP.
Protective anti-inflammatory effects of photobiomodulation with Red/NIR light in a mouse model of LPS-induced systemic and brain inflammation
Authors: Shamloo Shirin , Defensor Erwin , Ciari Peter , Ogawa Gaku , Vidano Laura , Lin Jennifer S. , Fortkort John A. , Shamloo Mehrdad , Barron Annelise E.
Published: December 2022

Background
There is an urgent need for therapeutic approaches that can prevent or limit neuroinflammatory processes and prevent neuronal degeneration. Photobiomodulation (PBM), the therapeutic use of specific wavelengths of light, is a safe approach shown to have anti-inflammatory effects. The current study was aimed at evaluating the effects of PBM on LPS-induced peripheral and central inflammation in mice to assess the potential of PBM as an anti-inflammatory treatment.
Methods
Effects of PBM were evaluated in group-housed C57BL/6J mice. Mice were divided into three groups: (a) a control group receiving no PBM, (b) a group receiving PBM utilizing red/NIR light at 640 and 880 nm (RL), and (c) a group receiving RL with a 40 Hz gamma frequency flicker (RLG). PBM was administered over 12 days (5 days per week for 2 weeks; no treatment on days 6 and 7). Each PBM treatment was 30 minutes. On day 11, mice were dosed by intraperitoneal injection with either vehicle or LPS (1 mg/kg). Brain and plasma samples were collected on day 12, 24 hours after LPS/vehicle injection and after one final PBM treatment. Samples were investigated for inflammatory responses, using qPCR to measure mRNA expression and western blot and Luminex assays to measure protein expression levels.
Results
Analysis by qPCR revealed that PBM with RL and RLG significantly reduced the gene expression of IL-18, while RL also reduced IL-6 expression in the brain. Luminex analyses confirmed that LPS induced the expected robust upregulation of cytokines in plasma and the brain. In plasma, RL and RLG modulated LPS induction of IL-10, IL-1β, IL-22, and IL-7Rα. In addition, RL modulated LPS-induction of IL-18 and MIP-1β, while RLG modulated IP-10, IFN-γ, RANTES, MCP-1, IL-2Rα, and BTC. In hippocampal-containing brain tissue, RL and RLG prevented the LPS-induction of ST2 and IFN-α, while RLG also inhibited the LPS-induction of sRANKL, MCP-1, and IL-15.
Conclusions
Daily, 30-minute PBM treatment with RL or RLG for 10 days prior to an LPS challenge had anti-inflammatory effects in C57BL/6J mice, in the brain and systemically. RL, independent of gamma flicker, provided robust anti-inflammatory effects, and the addition of gamma flicker further potentiated these effects. Overall, these results show the potential of PBM as an experimental anti-inflammatory treatment. Future studies will be needed to understand the mechanism of action, safety, and effectiveness of PBM.
Bond trustees and debt sustainability in sovereign debt restructuring
Authors:   , Pustovit Grygoriy
Published: December 2022

The expansion of actors and instruments in sovereign debt markets through bond financing generated a coordination problem among bondholders during the debt restructuring process. There is a risk that an individual bondholder will be passive or act against the restructuring slowing down or even precluding the process of restructuring even though it is in the general interest of bondholders as a group, not to mention the population of the country experiencing the shortage of funds for public welfare. In particular, the disruptions to sovereign debt restructuring by frivolous litigation is considered as one of the main threats. This dissertation is the first major study devoted to sovereign bonds structured through a trust arrangement and the promising features that such a legal structure possesses for an effective and efficient sovereign debt restructuring. It provides a comprehensive inquiry into the evolution of the mechanisms to coordinate creditors, with a focus on bondholders and institutional frameworks which facilitated this coordination. It examines intriguing primary sources from League of Nations archives and provides in-depth case studies on the functionality of the trustees in sovereign bond restructurings performed by Argentina in 2016 and Ecuador in 2008. Assessing the utility of trust arrangements to address coordination problems, this thesis is driven by the puzzle: How to better balance (i) the need for smooth sovereign debt restructurings, which by definition entails some losses for creditors, with (ii) bondholders’ legitimate interests? What approach can be used in constructing a legal and institutional framework for trustees to promote the best interest of the bondholders in sovereign debt restructuring? As a solution, it seems that incentives for bond trustees to pursue debt sustainability will achieve both goals. In this regard, recognition of the concept of debt sustainability, being in substance the IMF and WB debt sustainability assessment, as the best interest of bondholders in sovereign debt restructuring is beneficial from multiple aspects. It enables a bond trustee to excel in its role as a guardian of bondholders by following the best interest of bondholders in exercising its discretion. Moreover, it fosters an equilibrium between the interests of private creditors and a state taking into account its socio-political aspects.
Method for determining the time of opening and freezing of the river by protected multispectral satellite data and measurements by the MODIS instrument
Authors:   Tomsk State University of Control Systems and Radioelectronics (TUSUR), Kataev M. Yu. , Lukyanov A. K. ,   Tomsk State University of Control Systems and Radioelectronics (TUSUR), Tkachenko P. N. ,   Academy of the Ministry of Emergency Situations of Russia
Published: December 2022

An observation of surface waters is of a great importance for environmental, hydrological research, as well as practical applications and for the Russian Ministry of Emergency Situations. This article deals with the issue of detection and monitoring of surface waters using optical remote sensing by the MODIS multispectral satellite instrument. The current status and problems in this area are briefly discussed. The water detection is based on an analysis of NDVI vegetation index values calculated from measurements throughout the year from a clear division by value of plant, snow or water index values. Based on this, a spatio-temporal mask of water objects or a mask is built, the pixels of which are only used to analyze the values of the vegetation index. Next, the graphs of spatiotemporal dynamics of water mask pixels and construct smoothed values are considered. The following step is related to the search in these dependencies for the moment of opening of the river from winter ice and freezing of the river. A description is given of the processing of real measurements for the territory of the Ob-Tom interfluve, in the region of the city of Tomsk.
Modification of the method for developing combinatorial generation algorithms based on the use of multivariate generating functions and approximations
Authors:   Tomsk State University of Control Systems and Radioelectronics (TUSUR), Kruchinin D. V.
Published: December 2022

This article proposes a modified method for developing combinatorial generation algorithms based on AND/OR trees. The proposed method differs from the original method and its modifications by using the method of obtaining explicit expressions for the coefficients of multivariate generating functions to find the expression for the cardinality function of a given combinatorial set (including combinatorial sets defined by several parameters). Also, the proposed method is distinguished by the use of approximation methods and the binary search to find the selected son of the OR node. This reduces the computational complexity of the unranking algorithms. In order to test the proposed method, a new ranking and unranking algorithms were developed for a combinatorial set of selfavoiding lattice paths. In this case, the use of binary search reduced on average the number of required computational operations and a better computational complexity compared to the original version of the algorithm were obtained.
LOCALLY ADVANCED ORAL KAPOSIS SARCOMA IN AN HIV NEGATIVE WOMAN TREATED WITH EXCLUSIVE RADIOTHERAPY: CASE REPORT
Authors:   Department of Radiotherapy and Brachytherapy, Hospital of Oncology, CHU Hassan II, Fez, Morocco., Assenhaji Louizi B. , Saoudi M. T. ,   Medical Oncology Department, Oncology Hospital, CHU Hassan II, Fez, Morocco., Uakkas A. ,   Department of Radiotherapy and Brachytherapy, Hospital of Oncology, CHU Hassan II, Fez, Morocco., Erraisse M. Ait ,   Department of Radiotherapy and Brachytherapy, Hospital of Oncology, CHU Hassan II, Fez, Morocco., Hassani W. ,   Department of Radiotherapy and Brachytherapy, Hospital of Oncology, CHU Hassan II, Fez, Morocco., Farhane FZ. ,   Department of Radiotherapy and Brachytherapy, Hospital of Oncology, CHU Hassan II, Fez, Morocco., Alami Z. ,   Department of Radiotherapy and Brachytherapy, Hospital of Oncology, CHU Hassan II, Fez, Morocco., Bouhafa T. ,   Department of Radiotherapy and Brachytherapy, Hospital of Oncology, CHU Hassan II, Fez, Morocco.
Published: December 2022

The occurrence of oral Kaposis sarcoma (KS) in HIV-seronegative people is extremely rare. Mucosal lesions in VIH seronegative patients have been reported, making it a challenging diagnosis to identify and manage. Here, we present a 54-year-old seronegative patient who underwent radiation therapy as the only course of treatment for a locally advanced palatal mucosal kaposi sarcoma. The outcomes of the treatment in terms of tumor control and the immediate relief of our patients symptoms illustrate its effectiveness and support kaposi sarcoma radiosensitivity.
CLIMATE CHANGE IN INDIA: GAPS IN POLICIES AND PRACTICES
Authors:   Masters in Resource Management and Design Applications., Nagar Vaishali
Published: December 2022

This study was carried out to understand the gaps between the targets and achievements in government climate change policies and the sufficiency of government policies and decisions regarding climate change. For this research paper secondary research was conducted. Various government reports from IPCC, the Ministry of Environment, Forest and Climate Change, and the Ministry of New and Renewable Energy were analyzed. The study revealed that the government is lacking behind in achieving the targets for the year 2022. Out of the 100 GW target, only 40.1 GW of solar energy is installed in the country. India is ranked 180th among 180 countries in the Environmental Performance Index (EPI) 2022. There are targets in place, but the specific plan of action to deal with the issues of climate change are lacking. Its high time the Indian government shall take the right decisions for protecting the environment and addressing the issue of climate change with an accurate approach.
LE CARCINOME ADENOIDE KYSTIQUE DE LA FOSSE NASALE: A PROPOS DUN CAS ET REVUE DE LA LITTERATURE
Authors:   Departement De Radiotherapie, Institut National Doncologie, Maroc., Nouni K. , Fares H. ,   Departement De Radiotherapie, Institut National Doncologie, Maroc., Elmajjaoui S. ,   Departement De Radiotherapie, Institut National Doncologie, Maroc., Kebdani T. ,   Departement De Radiotherapie, Institut National Doncologie, Maroc., Elkacemi H. ,   Departement De Radiotherapie, Institut National Doncologie, Maroc., Hassouni K. ,   Departement De Radiotherapie, Institut National Doncologie, Maroc.
Published: December 2022

Adenoid cystic carcinoma of the nasal cavity is a rare malignancy. It is a slowly progressive disease, characterized by local recurrences and distant metastases and requires early and adequate management. We report a case of Adenoid cystic carcinoma of the nasal fossa and will discuss the diagnostic and therapeutic characteristics in the highlight of a review of the literature.
The effect of mall ambiance, layout, and utility on consumers’ escapism and repurchase intention
Authors: Sharma Renu , Mohan Mamta , Kumar Gupta Sandeep
Published: December 2022

Shopping malls are visited for both functional as well as entertainment values. They provide emotional comfort and escape from boredom and stress to the shoppers. This study investigates the relationship of ambiance, layout, and utility of a mall with escapism and repurchase intention using the Stimulus-Organism-Response (SOR) model. Using a survey instrument, a convenience sampling procedure was adopted to obtain data from 316 respondents (mall visitors of the Delhi National capital Region in India). Delhi is the mall capital of India, with the highest population density in the world. The relationships between utility-escapism (β = .0265, p = .018), layout-escapism (β = 0.269, p = .012), layout-utility (β = 0.776, p < 0.001), utility-ambiance (β = 0.480, p < 0.001), layout-ambiance (β = 0.407, p < 0.001), and escapism-repurchase intention (β = 0.708, p < 0.001) are validated. However, the relationship between ambiance-escapism (β = 0.073, p = .509) is not supported. The results indicate that mall layout facilitates escapism followed by utility, whereas ambiance does not play a vital role. The purpose of the mall visit moderates this effect. Mall managers can create engaging shopping experiences to help shoppers escape boring routines/stress through improved layouts and enhanced functional values. The study establishes a strong linkage between mall layout, utility, and escapism.
Influence of some plant nutrients on sweet cherry cultivars grafted on plum rootstocks (Prunus cerasifera) in soil with high pH
Authors: YILMAZ Cafer Hakan , UĞUR Remzi
Published: December 2022

This study was aimed to investigate the ability of the plums belonging to Prunus cerasifera species to be rootstock to some cherry cultivars and to examine the effect of rootstock, variety and their combinations on mineral nutrition. Rootstock-scion relationship and plant nutrient transmission were investigated in Napoleon, Starks Gold and Lambert cherry cultivars grafted on 10 selected rootstocks. As a result of the investigations, it was determined that the selected rootstocks were quite effective in transmitting the macro and micro plant nutrients to the cherry cultivars. It was noteworthy that the foliage phosphorus (0.15-0.52%) and potassium (1.65-4.00%) contents of the rootstocks were high. Although the leaf iron contents of rootstocks (49.11-74.42 mg kg-1) remained relatively below the reference values, deficiency symptoms such as chlorosis were not observed in the leaves. A strong correlation (r = 0.780**) was found between leaf chlorophyll contents and Cu. Translocated graft incompatibility was observed in some rootstocks. In combinations with not good graft compatibility, decreases in the transmission of plant nutrients were determined in general. At the end of the study, the idea that Prunus cerasifera wild plum species can be a good clone rootstock alternative for sweet cherry growing in high pH soils has emerged.
Heavy metal (Cr, Cu, Ni, Pb, and Zn) contents of endemic Salvia halophila plants around Lake Tuz
Authors: BAYSAL FURTANA Gökçen , DEMİR Aynur , TEKŞEN Mehtap , RASHIDI Adeleh , TIPIRDAMAZ Rukiye
Published: December 2022

Heavy metals occur naturally in ecosystems at varying concentrations. However, heavy metal sources that have emerged in present-day mainly due to human influence, i.e. industrial activities, agricultural waste, pesticides, use of fossil fuels and traffic, have included a part of heavy metals in the ecosystem. Lake Tuz, together with the entire lake surroundings, water beds and important steppe areas, was declared Turkey’s Specially Protected Area (SPA) in 2001. Our aim in this investigation was to determine the levels of heavy metals such as Chrome (Cr), Copper (Cu), Nickel (Ni), Lead (Pb) and Zinc (Zn) in endemic Salvia halophila grown in different areas of Lake Tuz. The results of the heavy metal contents analyzed at the plant were compared with the international standard levels of heavy metals. The consequences displayed that differing extents of heavy metals are accumulated in S. halophila. The results obtained differed in accordance with the collection time and localities. When the outcomes are appraised, it is achievable to say that Pb is higher than the standard values. The findings of this investigation are the first reported results for this endemic S. halophila species that grows naturally at Lake Tuz and are important as they are newly discovered results.
Matematik Eğitiminde Beceri Temelli Sorulara İlişkin Araştırmaların Tematik Analizi ve Matematik Eğitimine Yansımaları
Authors: Duran Barış , Bahadır Elif
Published: December 2022

Bu çalışmanın amacı, 2018-2022 yılları arasında yapılan beceri temelli sorularla ilgili araştırmaları incelemek ve incelenen tematik konulardaki eğilimleri ortaya çıkarmaktır. Çalışmada 17 makale ve 6 yüksek lisans tezi doküman incelemesi yöntemiyle analiz edilmiştir. Yapılan araştırmada incelenen çalışmaların yayın türüne ve tarihine, araştırma yöntemlerine, örneklem gruplarına, veri toplama araçlarına, araştırma desenlerine, konu alanlarına ve elde edilen sonuçlara göre dağılımı sınıflama yoluyla incelenmiştir. Araştırma sonucunda yapılan çalışmaların yeterli kapsam ve çeşitliliğe ulaşmadığı, çalışmaların daha çok 8. sınıf öğrencileri ve 8. sınıflara derse giren öğretmenler üzerinde yapıldığı, verilerin toplanmasında doküman inceleme ve yarı yapılandırılmış görüşme formlarının ve anketlerin kullanıldığı, araştırma desenlerinden ise durum çalışması ve ilişkisel tarama desenlerinin kullanıldığı belirlenmiştir. Bu durumdan hareketle beceri temelli sorular alanındaki çalışmaların genel eğilimleri tespit edilmiş ve üzerinde yeteri kadar çalışılmamış konular ortaya çıkarılmıştır. Elde edilen sonuçların beceri temelli sorular alanında yapılacak olan yeni çalışmalar için araştırmacılara yol gösterici nitelikte olacağına inanılmaktadır.
Effects of Coffee Supplementation on Homocysteine and Leptin Levels: A Systematic Review and Meta-analysis of Clinical Trials
Authors: Simental-Mendía Luis E. , Simental-Mendía Mario , Ríos-Mier Mayela
Published: December 2022

Background:

It has been reported that the consumption of antioxidant foods and beverages may benefit
the development of cardiovascular risk factors. However, the impact of coffee consumption on some of these
factors, such as homocysteine and leptin is controversial. Some clinical trials have suggested that coffee administration
increases plasma total homocysteine levels, while others have found no significant changes in
leptin concentrations.

Objective:

This study aimed to assess the effects of coffee supplementation on homocysteine and leptin concentrations
in a meta-analysis of clinical trials.

Method:

PubMed, Web of Science, Scopus, ClinicalTrials.gov, and Google Scholar databases were searched
from inception to September 29, 2021. A fixed-effects model and the generic inverse variance weighting
method were used for meta-analysis.

Results:

The meta-analysis demonstrated that coffee administration significantly increases homocysteine levels
(WMD: 0.55 μmol/L, 95% CI: 0.17, 0.93, p = 0.005, I2 = 0%) but has no significant changes in leptin concentrations
(WMD: 1.34 ng/mL, 95% CI: -0.78, 3.45, p = 0.21, I2 = 0%). Additionally, the sensitivity analysis was robust
for both homocysteine and leptin levels.

Conclusion:

The results of the present meta-analysis revealed that coffee supplementation raises serum homocysteine
concentrations but has no effect on circulating leptin levels.
Ocimum sanctum [Tulsi] as a Potential Immunomodulator for the
Treatment of Ischemic Injury in the Brain
Authors: Yadav Inderjeet , Kumar Ravi , Fatima Zeeshan , Rema Velayudhan
Published: December 2022

Stroke causes brain damage and is one of the main reasons for death. Most
survivors of stroke face long-term physical disabilities and cognitive dysfunctions. In
addition, they also have persistent emotional and behavioral changes. The two main
treatments that are effective are reperfusion with recombinant tissue plasminogen activator
and recanalization of penumbra using mechanical thrombectomy. However,
these treatments are suitable only for a few patients due to limitations such as susceptibility
to hemorrhage and the requirement for administering tissue plasminogen activators
within the short therapeutic window during the early hours following a stroke. The
paucity of interventions and treatments could be because of the multiple pathological
mechanisms induced in the brain by stroke. The ongoing immune response following
stroke has been attributed to the worsening brain injury. Hence, novel compounds with
immunomodulatory properties that could improve the outcome of stroke patients are
required. Natural compounds and medicinal herbs with anti-inflammatory activities and
having minimal or no adverse systemic effect could be beneficial in treating stroke.
Ocimum sanctum is a medicinal herb that can be considered an effective therapeutic
option for ischemic brain injury. Ocimum sanctum, commonly known as holy basil or
“Tulsi,” is mentioned as the “Elixir of Life” for its healing powers. Since antiquity, Tulsi
has been used in the Ayurvedic and Siddha medical systems to treat several diseases.
It possesses immuno-modulatory activity, which can alter cellular and humoral immune
responses. Tulsi can be considered a potential option as an immuno-modulator for
treating various diseases, including brain stroke.

:

In this review, we will focus on the immunomodulatory properties of Tulsi, specifically
its effect on both innate and adaptive immunity, as well as its antioxidant and antiinflammatory
properties, which could potentially be effective in treating ongoing immune
reactions following ischemic brain injury.
Overall Role of Contactins Expression in Neurodevelopmental Events and Contribution to Neurological Disorders
Authors: Bizzoca Antonella , Jirillo Emilio , Flace Paolo , Gennarini Gianfranco
Published: December 2022

Background:

Neurodegenerative disorders may depend upon a misregulation of the pathways which sustain neurodevelopmental control. In this context, this review article focuses on Friedreich ataxia (FA), a neurodegenerative disorder resulting from mutations within the gene encoding the Frataxin protein, which is involved in the control of mitochondrial function and oxidative metabolism.

Objective:

The specific aim of the present study concerns the FA molecular and cellular substrates, for which available transgenic mice models are proposed, including mutants undergoing misexpression of adhesive/morphoregulatory proteins, in particular belonging to the Contactin subset of the immunoglobulin supergene family.

Methods:

In both mutant and control mice, neurogenesis was explored by morphological/morphometric analysis through the expression of cell type-specific markers, including b-tubulin, the Contactin-1 axonal adhesive glycoprotein, as well as the Glial Fibrillary Acidic Protein (GFAP).

Results:

Specific consequences were found to arise from the chosen misexpression approach, consisting of a neuronal developmental delay associated with glial upregulation. Protective effects against the arising phenotype resulted from antioxidants (essentially epigallocatechin gallate (EGCG)) administration, which was demonstrated through the profiles of neuronal (b-tubulin and Contactin 1) as well as glial (GFAP) markers, in turn indicating the concomitant activation of neurodegeneration and neuro repair processes. The latter also implied activation of the Notch-1 signaling.

Conclusion:

Overall, this study supports the significance of changes in morphoregulatory proteins expression in the FA pathogenesis and of antioxidant administration in counteracting it, which, in turn, allows to devise potential therapeutic approaches.
In-vitro and In-vivo Neutralization Activity of Methanol Extract of
Adansonia digitata Fruit Pulp against Naja nigricollis Venom
Authors: Elijah John Oluwamayokun , Mamman Mohammed , Sani Dahiru , Yusuf Peter Ofemile , Jolayemi Kelvin Olutimilehin , Elijah Mary Oluwatomisin , Ameh Matthew Philip , Otie Dennis
Published: December 2022

Background:

Adansonia digitata has been used as a traditional medicine to treat various
diseases including snakebite envenomation.

Objective:

In this study, the protective and ameliorative potentials of crude methanol extract of Adansonia
digitata fruit pulp against crude venom of Naja nigricollis in-vitro and in-vivo were investigated.

Method:

The dose-dependent inhibitory studies, pharmacological, histopathological and in vivo studies
were conducted using standard methods.

Result:

The mean lethal dose of the crude methanolic extract of Adansonia digitata fruit pulp in
Wistar rats was > 5,000 mg/kg, while Naja nigricollis venom was 0.89 mg/kg. The anti-lethality effective
concentration of the fruit pulp on Naja nigricollis venom was 92.52 mg/ml. Treatment significantly
(< 0.05) inhibited the activities of Naja nigricollis phospholipase A2 and dose-dependently reduced
Naja nigricollis venom-induced paw oedema at 1-4 hours post-envenomation. In-vivo, treatment
with 250 and 500 mg/kg of Adansonia digitata fruit pulp was protective against the clinical signs and
mortality. Serum acetylcholinesterase activities were maintained in the group treated with normal saline
and the ameliorative groups but decreased significantly (p < 0.05) in other groups. Brain acetylcholinesterase
was high in all the groups by day 1 but was reduced with increasing dose by day 2 in the
ameliorative groups only. Adansonia digitata fruit pulp also preserved the histoarchitecture of the
brain, heart, liver and spleen from venom-induced pathologies.

Conclusion:

Crude methanolic extract of Adansonia digitata fruit pulp possesses good protective and
ameliorative neutralization effects on Naja nigricollis venom and could be promising in the management
of snakebite envenomation.
O estabelecimento de relações de discurso como manobra discursiva no processo de gestão de faces e territórios em uma entrevista jornalística
Authors: Braga Paloma Bernardino , Brito Daniel Martins de
Published: December 2022

Throughout interactions, the interlocutors use different discursive maneuvers to achieve their communicative goals. One of these maneuvers is the establishment of discourse rela-tions to articulate textual constituents in order to manage faces and territories. From this perspec-tive, our article investigates how interactive discourse relations (argument, counter-argument, re-formulation, preliminary, and so on.) are used on the facework of a written interview, published in 2019 in the interview section of the 2nd edition of Folha de S. Paulo, whose participants were: Anna Virginia Balloussier (AVB), a journalist of Folha, and Marcello Crivella (MC), who, at the time, was mayor of Rio de Janeiro. Our hypothesis is that these discourse relations play an important role in the facework, thus acting as interactional resources through which the interview participants try to achieve their communicative goals and negotiate identity images. To carry out this analysis, we used as our theoretical-methodological framework the Geneva Modular Approach to Discourse Analy-sis, which is a cognitive-interactionist approach that aims to account for discursive complexity by breaking it down into smaller units
Reimagined Family Ties: Redressing Memory through Photography in Aline Motta’s "Pontes sobre abismos" and "Filha Natural"
Authors: Fernandez Maria Emilia
Published: December 2022

This article investigates the work of Aline Motta, a contemporary Brazilian artist who is proposing different ways of looking at the past while also addressing the interlocking forms of oppression at work in the present. Through her collaborations with ancestors, in which photography plays a crucial role, the artist reflects on the colonial trauma of over three centuries of genocide, slavery and colonization in Brazil. Moreover, I argue that her work invites a rearrangement of our perception of time and contributes to a critique of linear temporality, evincing the falseness of any narrative of the past as single, stable and flowing in only one direction. This research is guided by questions such as: How can photography serve as a medium of fabulation and of imagining family ties across time and space? And how can these gestures signal the way, if not toward healing, towards an ever-incomplete practice of redress?
A personagem lésbica no cinema brasileiro realizado por mulheres durante a ditadura civil-militar (1964-1985)
Authors: Cavalcante Alcilene
Published: December 2022

Neste artigo, abordamos os termos da representação lésbica em dois longas-metragens, de ficção, realizados por mulheres no Brasil, no período de ditadura civil-militar (1964-1985). Analisamos Marcados para viver (1976), de Maria do Rosário Nascimento e Silva, e Amor maldito (1984), de Adélia Sampaio.  Partimos de referenciais feministas do cinema, que reconhecem o jogo de (in)visibilidade lésbica em cinematografias, desde filmes clássicos de Hollywood, sustentando que, apesar de códigos de censura e do padrão de heterossexualidade compulsória ou de heteronormatividade, as lésbicas sempre apareceram neles, mesmo que de maneira fantasmagórica. ======
In this article, I address the terms of lesbian representation in two fictional feature films directed by women in Brazil during the period of civil-military dictatorship (1964-1985), namely Marcados para viver (1976), by Maria do Rosário Nascimento e Silva, and Amor maldito (1984), by Adélia Sampaio. Beginning with feminist references in cinema, which have recognized the play of lesbian (in)visibility in cinematographies since the classic age of Hollywood, I maintain that, despite censorship codes and the standard of compulsory heterosexuality or heteronormativity, lesbians have always been present, even if in a ghostly manner.
An Interview with Dr. Masahiro Sato
Authors: Editorial Office OBM Genetics
Published: December 2022

InterviewAn Interview with Dr. Masahiro SatoOBM Genetics Editorial OfficeLIDSEN Publishing Inc., 2000 Auburn Drive, One Chagrin Highlands, Suite 200, Beachwood, OH, USA; E-Mail: genetics@lidsen.comOBM Genetics2022, volume 6, issue 4doi:10.21926/obm.genet.2204174Received: December 13, 2022Accepted: December 13, 2022Published: December 14, 2022
Nano fertilizer spraying affects the yield of Sorghum (Sorghum bicolor L.) varieties.
Authors: Al-Rubaie M.A.J. , Mohammed Ahmed R. , S. Ali Husham
Published: December 2022

The field experiment was carried out at the Abu Ghraib Agricultural Research Station Iraq (AGARSI), affiliated with the Agricultural Research body-Ministry of Agricultural of Iraq, to study the spraying with nano fertilizers and the stages of the yield and yield components of varieties of Sorghum. The experiment was designed as a spilled-spilled-plot according to the (RCBD) of three replicates. The main plots involved three varieties of Sorghum (Rabih, Lilo, and Inqath). In contrast, the subplots involved spraying the nano-fertilizers (Nano-Iron and Nano-Zinc) and the control treatment (distilled water). The sub-sub-plots involved the spray stages (Spraying at emerging five leaves, spraying at emerging the last folded leaf, and spraying at 50% flowering stage). The results showed that there were significant differences in all traits, where the variety Inqath had the highest was superior in panicle weight (g), the number of grains per panicle, (CGR)(gm-2.day-1), and grain yield (tons.ha-1). Nano iron was also superior in four traits, panicle weight (g), the number of grains per panicle (CGR)(g.m-2.day-1), and grain yield (tons.ha-1). For the spray stage, the stage of the emergence of five true leaves (S1) was significantly superior in the traits of panicle weight (g), the number of grains per panicle, (CGR)(g.m-2.day-1), and grain yield (tons.ha-1). Keywords: Nano fertilizers; Nano-Iron; Nano-Zinc; grain yield.
Estimation of path coefficient analysis for some quantitative traits in Rice ( Oryza sativa L.) genotypes
Authors: Al-Musawi Balqees , Al- Anbari Mohammed
Published: December 2022

A field experiment was conducted at the Al Mushkab Rice Research Station (AMRR), Najaf, Iraq, during the rice growing season of 2018-2019 in Randomized Complete Block Design (RCBD) for the aim of estimating the path coefficient in 15 introduced and local genotypes of rice. The path coefficient was estimated for the number of days from planting to 50% flowering, the number of days from flowering to physiological maturity, plant height, leaf area index, number of branches/panicle, number of panicles / m2, number of grains/panicles, infertility percentage (sterility %), 1000 grains weight (gm), biological yield (kg. ha -1) and harvest index (HI %) with grain yield kg, ha. -1. The results of the study concluded that the trait of harvest index is an effective selection criterion for improving Rice grain yield because it achieved the highest overall positive effect, i.e., the highest positive genotypic correlation amounted to 0.761, and this trait also achieved a high direct positive effect on grain yield amounted to 0.83833.

Keywords: Rice, Genotypes, Path Coefficient, Harvest Index
Effect of chemical fertilizer and humic acid on cabbage leaves' N, P, K and S concentrations (Brassica oleracea var. capitata L.)
Authors: Ibrahim Turki Miaad , Rahem Bader Basem
Published: December 2022

A field study was carried out in one of the fields of Jdeidet Al-Shatt district is, located 30 km from the center of Baquba in Diyala governorate, during the autumnal season 2021-2022 on silty loam soil classified to a level under the Typic Torrifluvent according to the modern American classification to know the effect of adding chemical fertilizer and humic acid on the availability of nitrogen, phosphorus and potassium concentrations for cabbage leaves, according to of randomized complete block design (RCBD) by using three replicates. The first factor was the chemical compound fertilizer NPK( 20:20:20 ) added at three different levels 0, 150 kg ha-1, 300 kg ha-1, while the second factor was humic acid at three levels 0, 15 kg ha-1, 30 kg ha-1. Fertilizers were added to the soil by making an incision around the plant and were added in two stages, the first when planting and the second 43 days after the date of the first batch. The results of the study showed that adding chemical fertilizer at a level of 300 kg ha-1 led to significant differences in the concentrations of nitrogen, phosphorous, potassium and sulfur elements in the inner leaves, where the concentrations of elements reached 2.55%,0.34%, 2.95%,1.36% respectively, the outer leaves. In contrast, the concentrations of nitrogen, phosphorous and potassium reached 4.00 %, 0.34%, and 2.67%, respectively, While the superiority of the humic acid at the level of 30 kg ha-1 to 2.33%, 0.32%, 2.77%,1.47% in the inner leaves, respectively, while in the outer leaves 3.80 %,0.31 %,2.49%. Keywords: chemical fertilizer, humic acid, concentrations of N,P, K and S, cabbage.
Epigenetic effects of selenium and vitamin E supplementation in broiler breeder diets on the performance of their progeny
Authors: Mahmoud Ali Fatima , Hamid Hassan Khalid
Published: December 2022

Nutritional supplements have been commonly used in the poultry industry last few years. The study aimed to investigate the epigenetic effects of adding vitamin E and organic selenium to the diet of broiler breeders Ross-308 on their progeny meat production performance. The treatments included the control group fed with a standard diet without supplementation (T1), T2 using a standard diet supplemented with 500 mg of vitamin E / kg, T3 using a standard diet supplemented with 0.5 mg of organic selenium (Availa powder) /kg, and T4 using a standard diet supplemented with a mixture of vitamin E and organic selenium in proportions 500 and 0.5 mg/kg respectively. The eggs were collected from each treatment to obtain the progeny reared for 35 periods, and measurements were recorded for meat production and carcass traits. The results showed that the treatments had significant epigenetic effects on body weight at hatching. Hence, T2 had a significantly heavier body weight than T1, while no significant differences were observed between T3 and T4. The result of T2 recorded extremely high feed intake compared with T3. On the other hand, T3 and T4 recorded a hefty weight of breast parts compared with T1 and T2.

In conclusion, organic selenium supplementation led to a significant increase in breast weight and a decrease in thigh part weight compared to the control group. In contrast, vitamin E supplementation led to an increase in chick weight at hatch, a reduction of total mortality and an improvement in feed conversion ratio compared to the control group. This refers to the epigenetic effects of organic selenium and vitamin E on progeny traits when added to the breeder diet.

Keywords: Epigenetics, broiler, selenium supplementation, meat production