bluuebunny/crossref_metadata_2025 huggingface dataset:
Microstructure and Wear Behaviour Assessment of Different Micron-Sized B4C Reinforced Al2021 Alloy Composites
Authors: Abdulhadi Ahmed M. , Namdev Nagaraj , Subhas Chandra T. , Chavan Veerashetti S. , Majdi Ali , Mohammed Salah J. , Raichur Satyabodh , Auradi V. , Manjunatha T. H.
Published: July 2024

This study examines the impact of the size and wt.% of reinforcement particles on the wear characteristics of Al2021 alloy composites. Composites of Al2021 reinforced with B4C particles of varied sizes (45 and 90 microns) were synthesised utilising a unique two-stage stir cast technique. The composites were primed with B4Cc content of 5 and 10 wt.%. The microstructural characterisation of Al2021 alloy with B4C composites of 45 and 90-micron sizes was conducted using Scanning Electron Microscope (SEM) and Energy Dispersive Spectroscopy (EDS). In addition, wear and worn morphology tests were conducted to examine the impact of particle size on the behaviour of Al2021 alloy. Furthermore, another set of wear studies was conducted with the load maintained at 40N and the sliding speeds changed from 100 to 400 rpm. The microstructural analysis disclosed that the particles in the Al2021 alloy were evenly distributed, and the presence of elements was verified using EDS spectra. Using B4C particles of different sizes enhanced wear characteristics with resistance to wear. The load and the speed affected the wear behaviour of every prepared sample. The morphological analysis of the worn samples recognised multiple wear mechanisms.
A másodnyelvi kölcsönszavak fonetikai adaptációja a kárpátaljai magyar és ukrán nyelvváltozatokban
Authors: Bárány Erzsébet , Gazdag Vilmos
Published: July 2024

A kölcsönszavak fonetikai változásainak a tanulmányozása fontos szegmensét képezi a kontaktusnyelvészetnek. Különösen nagy jelentősége van a hangtani kérdések tanulmányozásának azokban az esetekben, amikor egymással rokonságot nem mutató nyelvek közötti kapcsolatról, s az e kapcsolatok nyomán meghonosodott kölcsönszavakról kívánunk szót ejteni. Ilyen jellegű kapcsolatról kell beszélnünk a szláv nyelvcsaládba tartozó ukrán/orosz és a finnugor nyelvcsaládba tartozó magyar nyelv esetében is. Az ukrán, az orosz és a magyar nyelv hangrendszeri eltérései kiváló lehetőséget adnak arra, hogy a kölcsönszavak meghonosodásuk során jellegzetes hangtani módosulásokon menjenek keresztül, legyen szó akár az ukránban és az oroszban meghonosodott hungarizmusokról, akár a magyar nyelvbe átkerült ukrán és orosz lexikai elemekről. Jelen munkában a kárpátaljai és más nyugat-ukrajnai ukrán nyelvű szépirodalmi művekben előforduló magyar kölcsönszavak, illetve a kárpátaljai magyar nyelvjárásokban meghonosodott orosz és ukrán kölcsönszavak meghonosodása során végbemenő hangtani változások főbb sajátosságait próbáljuk meg vázlatosan összefoglalni.
Nyelvi adatok a madéfalvi veszedelem után megszervezett Bűnfenyítő Bizottság tanúkihallgatási jegyzőkönyvéből
Authors: Pál Helén
Published: July 2024

A dolgozat az 1764-es madéfalvi veszedelem után felállított Bűnfenyítő Bizottság jegyzőkönyvének nyelvével foglalkozik. A magyar nyelvű jegyzőkönyv nyelvén minden bizonnyal a leíró, Michael Conrad von Heidendorf nyelvváltozata is nyomott hagyott, de a dolgozatban elsősorban a kihallgatott székelyek nyelvét tanulmányoztam. Bemutattam a Bűnfenyítő Bizottság jegyzőkönyvét, majd a kihallgatások szövegének lejegyzőjét, elsősorban magyar nyelvtudása és a lejegyzés körülményeinek szempontjából. A jegyzőkönyv szövegében helyneveket, frazeologizmusokat és megszólításformákat is megörökítettek, emellett alaki, jelentésbeli és valódi tájszavakat is. Ezek egy részét megtalálhatjuk a bukovinai székelyek nyelvét ismertető kiadványokban, de akadnak olyanok is, amelyekre csak a moldvai magyarok nyelvében találtam példát. A nyelvi adatokat hangtani, alaktani és mondattani szempontból is megvizsgáltam, és a bemutatásukhoz adatokat gyűjtöttem a bukovinai székely nyelvjárási szövegekből. Mivel a jegyzőkönyvben azt is megörökítették, hogy kitől jegyezték le az adott vallomást, és az illető mely faluból származott, ezért a nyelvi adatokat a bukovinai székelyek nyelvén kívül az adott település nyelvjárásával is össze lehet hasonlítani.
EDITORIAL
Authors: . .
Published: July 2024

This is an Editorial and does not have an abstract. Please download the PDF or view the article in HTML.
Performance Evaluation of an Electric Drive System Applied to a Three-wheel Hybrid Prototype Vehicle for Urban Mobility
Authors: A Padilla C , E Audelo M , F Buenaño L , Choca C , Coello J
Published: July 2024

In this work, an electric traction system was implemented in a three-wheeled prototype vehicle for urban mobility. An electric motor kit including its controller and a handle-type accelerator is implemented to form a hybrid system of electric and human traction, where the human traction serves as a support when the battery is discharged. In order to move the vehicle, it is necessary to take the power from the motor to the driving wheel of the vehicle, therefore, it was designed and implemented with a transmission by sprocket and chain. Once all the mechanical and electrical components of the electric traction system have been assembled, tests are performed to determine the performance of the engine and transmission. An acceleration test is performed to determine the maximum speed and the time taken to reach, in addition to autonomy tests at a cruising speed of 30 km/h. The results of the acceleration tests show that the vehicle can go from 0 to 45 km/h in 17.6 ± 0.55 s on a maximum slope of 7.5% and in 14.8 ± 1.1 s on a straight road. The vehicle achieves a maximum range of 8.21 km with an average speed of 30 km. From the analysis of the results, it is concluded that the vehicle can perform adequately in urban environments.
Keywords: electric drive, battery, electric motor, electric vehicle, range, three-wheel prototype
Resumen
En el presente trabajo se implementó un sistema de tracción eléctrico a un vehículo prototipo de tres ruedas para movilidad urbana. Se implementa un kit de motor eléctrico que incluye su controlador y un acelerador tipo manija para conformar un sistema híbrido de tracción eléctrica y humana, en donde la tracción humana sirve de apoyo cuando la batería está descargada. Para mover el vehículo es necesario llevar la potencia del motor a la rueda motriz del vehículo, por lo que se diseñó e implementó una transmisión mediante piñón y cadena. Una vez realizado el ensamble de todos los componentes mecánicos y eléctricos del sistema de tracción eléctrico, se procede a realizar pruebas que permitirán determinar el desempeño del motor y transmisión implementados. Se realiza una prueba de aceleración para determinar la velocidad máxima y el tiempo empleado en alcanzarla, además de pruebas de autonomía a una velocidad crucero de 30 km/h. Como resultados se obtiene que en las pruebas de aceleración el vehículo es capaz de pasar de 0 a 45 km/h en 17.6 ± 0.55 s en una pendiente máxima de 7.5% y en 14.8 ± 1.1 s en recta. El vehículo alcanza una autonomía máxima de 8.21 km con una velocidad promedio de 30 km. Del análisis de resultados se concluye que el vehículo es capaz de desempeñarse adecuadamente en entornos urbanos.
Palabras Clave: Tracción eléctrica, Prototipo de tres ruedas, Batería, Motor eléctrico, Autonomía, Vehículo eléctrico.
How Does a Data-Informed Deliberate Change in Learning Design Impact Students’ Self-Regulated Learning Tactics?
Authors: Chen Zhongzhou , Zhang Tom , Taub Michelle
Published: July 2024

The current study measures the extent to which students’ self-regulated learning tactics and learning outcomes change as the result of a deliberate, data-driven improvement in the learning design of mastery-based online learning modules. In the original design, students were required to attempt the assessment once before being allowed to access the learning material. The improved design gave students the choice to skip the first attempt and access the learning material directly. Student learning tactics were measured using a multi-level clustering and process mining algorithm, and a quasi-experiment design was implemented to remove or reduce differences in extraneous factors, including content being covered, time of implementation, and naturally occurring fluctuations in student learning tactics. The analysis suggests that most students who chose to skip the first attempt were effectively self-regulating their learning and were thus successful in learning from the instructional materials. Students who would have failed the first attempt were much more likely to skip it than those who would have passed the first attempt. The new design also resulted in a small improvement in learning outcome and median learning time. The study demonstrates the creation of a closed loop between learning design and learning analytics: first, using learning analytics to inform improvements to the learning design, then assessing the effectiveness and impact of the improvements.
In vitro Study on the Immunomodulatory and Anti-inflammatory Effect of Soregen® Technology Water in Broiler and Layer Hens Peripheral Blood Mononuclear Cells
Authors: Purnamasari L. , Cruz J.F. dela , Lee D.B. , Choi Y.J. , Yi J.K. , Hwang S.G.
Published: July 2024

Background: Peripheral blood mononuclear cells (PBMCs) represent an attractive tissue source in pharmacogenomics and molecular and immunologic studies. In order to investigate the changes in biological effects, water samples were exposed to a specific quantum entanglement signal from the SoRegen chip for 48 hours. This study aimed to evaluate the immunomodulatory and anti-inflammatory effects of SoRegen Technology in broiler and layer hens PBMCs. Methods: Six-week-old Arbor Acress broiler chickens and 66-week-old layer hens Lohmann were used for the establishment of an in vitro cell culture model with chicken PBMCs. Result: The result indicates that post-treated water media enhanced the proliferative properties of broiler and layer hens PBMCs. The mRNA and protein expression of immune-modulating and pro-inflammatory cytokines: IL-2, IL-6, iNOS, IFNγ, TNFα and NFκB exhibited a marked increase following stimulation of the cells by LPS and Con A when compared with the non-stimulated cells. However, stimulated cells grown in structured water media showed a strikingly decreased expression of pro-inflammatory cytokines, except for the upregulation of IFNg expression in broiler PBMCs but not in layer hens PBMCs. It can be concluded that SoRegen® Technology water had anti-inflammatory activities with potential clinical immunomodulatory effects in younger chicks.
Management of Collar Rot Disease in Groundnut (Arachis hypogaea L.) Caused by Aspergillus niger in Rajasthan Through Bio-control Agents
Authors: Nathawat B.D.S. , Kumar Dinesh , Kumar Rakesh , Kumar Ravinder , Choudhary Raja Ram
Published: July 2024

Background: Groundnut is an economically important edible oilseed crop. Groundnut suffers from seed, soil and foliar diseases. Among the groundnut diseases, collar rot is one of the economically important diseases. Collar rot is damaged regularly due to its seed and soil-borne nature. This disease is prevalent in almost all groundnut-growing states. Collar rot disease of groundnut is one of the most serious, destructive diseases and yield losses range from 13 to 52% and can be as high as 93.6% in some areas. Being mainly a soil-inhabiting pathogen, many environmental and soil factors are responsible for disease development. Methods: Field experiment was conducted for four years to find out effective control of collar rot of groundnut. Eight treatments including fungicides/bio agents along with control were laid in randomized block design with three replications. Efficacy of deep summer ploughing with mould board plough+Seed treatment with Tebuconazole followed by PGPR+Soil application of Trichoderma enriched in 250 kg FYM/ha at 35 and 80 DAS along with farmer practices as well as control was tested at ARS, Bikaner in RBD design during kharif season from 2017 to 2020 for management of collar rot diseases of groundnut. Result: The result of experiment revealed that deep summer ploughing with mould board plough+Soil application of Trichoderma @ 4 kg/ ha enriched in 250 kg FYM/ha+Seed treatment with Tebuconazole 2 DS @ 1.5 g/kg of seed followed by seed treatment with PGPR @ 625 g/ha of seed+Soil application of Trichoderma @ 4 kg/ha enriched in 250 kg FYM/ha at 35 and 80 DAS (T4) gave maximum germination (93.00%), minimum collar rot incidence (6.17%) and highest pod yield (4066.3 kg/ha) followed by deep summer ploughing with mould board plough+Seed treatment with Tebuconazole 2DS 1.5g/kg seed followed by PGPR @ 625 g/ha of seed+Soil application of Trichoderma @ 4 kg/ ha enriched in 250 kg FYM/ha at 35 and 80 DAS (T1) where germination (89.30%), collar rot (7.04%) and with pod yield (3661.9 kg/ha). All the treatment significantly were superior as compared to control, where minimum germination (82.00), maximum collar rot incidence (15.59 %) and minimum pod yield (2125.1 kg/ha) were recorded. As regard to ICBR, in different treatments, maximum ICBR ratio (1:20.68) was recorded in treatment consisting (T4): Deep summer ploughing with mould board plough+Seed treatment with Tebuconazole 1.5 g/kg seeds+Soil application of Trichoderma @ 4 kg/ha enriched in 250 kg FYM/ha at 35 and 80 DAS followed by treatment (T1).
EDUCAÇÃO PERMANENTE: o uso de Tecnologias de Informação e Comunicação para a qualificação profissional
Authors: Bernardes Luzana Mackevicius , Lorandi Paulo Ângelo , Pamplona Ysabely de Aguiar Pontes , Martins Lourdes Conceição
Published: July 2024

O desenvolvimento de Tecnologias de Informação e Comunicação (TIC) é uma importante estratégia de educação em Saúde. Quando aplicada na perspectiva da Educação Permanente em Saúde (EPS), possibilita a transformação da práxis dos profissionais. Assim, a tele-educação interativa pode viabilizar o acesso dos trabalhadores do Sistema Único de Saúde (SUS) à formação e qualificação profissional. O presente estudo tem por objetivo analisar a implantação da tele-educação interativa sobre tuberculose para os profissionais da atenção primária à saúde em um município da região Metropolitana da Baixada Santista. Focaliza avanços e limites da educação a distância (EaD) como integrante do Programa de Educação Permanente. Trata-se de uma pesquisa qualitativa, pela análise do conteúdo. Como resultado, ressalta o caráter prático do EaD que possibilitou, horários flexíveis, causando impacto transformador na prática cotidiana e explicitou a necessidade de mais apoio dos gestores de todos os níveis para disponibilizar mais tempo e estrutura de acesso a essa ferramenta. Conclui-se que a tele-educação interativa é de grande relevância para a qualificação do profissional da atenção primária à saúde e, consequentemente, tem impacto positivo na melhoria da qualidade e resolutividade do atendimento ao usuário do SUS.
Asociación entre capital psicológico e iniciativa para el crecimiento personal en estudiantes de nivel secundario
Authors: Schönfeld Fátima Soledad , Hess Carina Daniela
Published: July 2024

El capital psicológico y la iniciativa para el crecimiento personal son recursos personales que pueden generar beneficios en diferentes ámbitos vitales, como el contexto escolar durante la adolescencia. Así, el objetivo del presente trabajo fue estudiar la correlación entre las variables en estudiantes de nivel secundario de la Provincia de Entre Ríos, Argentina, en tres momentos de su recorrido escolar. El estudio es cuantitativo, tratándose de una investigación longitudinal y descriptiva–correlacional. Para recolectar los datos se utilizó el Cuestionario de capital psicológico y la Escala de iniciativa para el crecimiento personal, ambos instrumentos adaptados a una muestra argentina. Se obtuvieron correlaciones estadísticamente significativas, de carácter positivo entre todas las dimensiones, en cada uno de los tres tiempos evaluados. A partir de los hallazgos encontrados, es factible suponer que un estudiante que posee los recursos que constituyen el capital psicológico también podrá contar con la capacidad de beneficiarse a partir de las oportunidades de cambio y crecimiento que se le vayan presentando. También se destaca que los puntajes de las asociaciones disminuyeron levemente hacia el final del tercer tiempo, coincidiendo con la adolescencia media. En esta etapa suele presentarse cierta inestabilidad, diversos cambios, dudas en cuanto al futuro; por todo ello, es fundamental la promoción de las fortalezas personales en los estudiantes adolescentes, promoviendo su desarrollo a través de intervenciones psicológicas.
Gebelerin Doğum Planı ve Bu Planı Etkileyen Faktörlerin Belirlenmesi
Authors: Özdilek Resmiye , Kısa Buse Nur
Published: July 2024

Bu çalışma, gebelerin kendilerinin oluşturduğu doğum planı ve bu planı etkileyen faktörlerin belirlenmesi amacıyla tanımlayıcı tipte gerçekleştirildi. Çalışmanın evrenini, Aralık 2022-Mart 2023 tarihleri arasında İstanbul’da bulunan Özel Hastanenin A ve B Şubeleri Kadın Hastalıkları ve Doğum Kliniğine doğum için başvuran 206 gebe oluşturdu. Veri toplamada tanıtıcı bilgi formu ve gebelerin doğum planını etkileyen faktörler anket formu ve doğum planı formu kullanıldı. Araştırmaya katılan gebelerin yarısının normal doğum yapmayı planladığı, doğum şeklini belirlemede yaklaşık yarısının hekim önerisinden etkilendiği saptandı. Doğum planında gebelerin yarısı ebe seçerken güvenilir olmasına dikkat ettiğini bildirdi. Gebelerin yarısından fazlasının doğumu kolaylaştırıcı ilaç dışı yöntemleri bildiği belirlendi. Gebeler, kendi doğumlarında sırasıyla mahremiyetine önem verilen (%78,2), loş (%71,4), sakin (%55,8) bir ortam istediğini belirtti. Doğum sırasında gebelerin yanlarında olmasını tercih ettikleri kişiler sırasıyla eş (%85,9), Ebe (%42,7), anne (%18,9) olarak belirlendi. Gebelerin doğum planında %78,6’sı doğumdan hemen sonra yenidoğan ile ten tene temas uygulanmasını bildirdi. Doğum planlarında gebelerin %26,7’si doğumundan sonra plasentasını almak istediğini bildirdi. Sonuç olarak araştırma bulgularına göre kadınların, kendi doğumlarında deneyimli hekim ve güvenilir ebelerin yer almasını, mahremiyetin sağlandığı bir ortamda, ilaç dışı doğumu kolaylaştırıcı yöntemlerin kullanıldığı doğum planladıkları söylenebilir.
APPLICATION OF CIRCULAR ECONOMY PRINCIPLES IN BUSINESS: THE CASE OF PRIMORSKO – GORANSKA COUNTY
Authors: Golob Martin , Golob Marino , t Nikolina
Published: July 2024

T he main aim of the paper was to investigate familiarity with CE principles, application intensity of CE and the need for CE education in business organizations in the area of the Primorsko – goranska County in the Republic of Croatia. A survey was conducted in 2023 in order to gather relevant data that can be analyzed for this specific purpose. The results are presented on the total sample od respondents, then differences were investigated between public and private sector employees, manufacturing and services sector employees, age groups and employees’ organization sizes. The overall findings suggest a lack of widespread understanding of CE principles among employees. The findings also support for an immediate educational effort focused on CE. The main findings of the survey indicate a higher prevalence of CE adoption in the private sector and among younger employees, predominantly in large organizations, but also highly adopted in micro and small business organizations.
OVERVIEW OF DIFFERENT IT SOLUTIONS FOR REDUCING NO-SHOWS AND UNEXPLAINED PATIENT CANCELLATIONS IN HEALTH TOURISM
Authors: Rajković Irijana , Baričević Dino , Šimunić Mislav
Published: July 2024

Purpose - In the dynamic world of health tourism, where more and more patients are travelling across different countries in search of healthcare and wellness services, missed appointments and unexpected cancellations, known as no-shows, have become a major challenge for this type of industry. These incidents affect the expansion of infrastructure, result in loss of revenue and negatively impact the waiting list and quality of care for other patients. This paper is an overview and review of 10 years of personal experience and different papers and articles that address these pressing health tourism challenges, their causes and possible solutions that could help minimise the number of no-shows. Therefore, the following hypothesis is put forward: H1 The integration of modern information and communication technology solutions can have a positive impact on the problem of patient no-shows and unexplained cancellations. Findings - Research shows that missed appointments and no-shows have multiple reasons, such as: “forgetfulness”, “transportation issues” and “time off work”. They also differ by type of health tourism, medical specialty, socioeconomic status, gender, age, place of residence, etc. Research also shows that no-shows cost the healthcare industry over 150 billion dollars annually. Design/methodology/approach - This paper reviews the existing literature and examines various tools, methods, strategies and techniques used to predict patient no-shows. It identifies the key factors that can help reduce the incidence of no-shows, optimise the scheduling process, and identify the current state of the art. It also describes ways to integrate advanced technologies such as patient management systems, mobile health apps, blockchain for secure data exchange and artificial intelligence (AI) for predictive analytics. Findings/Originality of the research – Correctly identifying whether scheduled patients will attend or miss their appointments allows clinics to strategically schedule patients, minimising the negative impact of patient no-shows. The number of patient no-shows in healthcare tourism and the constant search for solutions to minimise them demonstrate the difficulty of this problem and the need for further research.
Peran Psikologi Arsitektur dalam Mewujudkan Ruang Publik Terpadu Ramah Anak di Dataran Engku Putri Batam
Authors: Aguspriyanti Carissa Dinar , Benny Benny , Ayunda Rika , Artanti Nadiah K. , Khairi M. Zidane , Tysen Fedrico , Suwarlan Stivani Ayuning
Published: July 2024

Considering the needs of children as users is essential when creating Child-Friendly Integrated Public Spaces (RPTRA). Hence, this study sought to explore how the psychology of architecture focused on user psychology and behavior can contribute to the creation of RPTRAs. This research at Dataran Engku Putri, Batam City, utilised qualitative descriptive methods involving literature study and observation techniques. The results revealed that this public space was less adequate in meeting the RPTRA criteria including security and safety, recreational function and comfort, ease of accessibility, park attractiveness, health, meeting social needs, and learning elements. Therefore, it is necessary to improve and develop specialised play facilities for children based on the five aspects of psychology of architecture, namely space, size and shape, furniture and its arrangement, colour and texture, sound, temperature, and lighting.
Early identification of cardiac ATTR amyloidosis: a clinical case
Authors: Vedernikov A. A. , Mezhonov E. M. , Shirokov N. Е. , Balina V. A. , Reitblat O. M. , Teffenberg D. V. , Shalaev S. V.
Published: July 2024

Progress in instrumental diagnostics, as well as increased awareness among doctors about rare diseases, is steadily leading to an increased number of patients diagnosed with cardiac amyloidosis. Regardless of amyloid formation route, cardiac damage is the main cause of mortality in systemic amyloidosis. The article presents a unique clinical observation of hereditary transthyretin (ATTR) amyloidosis mixed phenotype detection during skeletal scintigraphy. In the patient with severe shortness of breath, based on the results of radiological research, an oncological process in the lungs was suspected. The patient underwent skeletal scintigraphy to exclude metastatic lesions, during which a scintigraphy pattern characteristic of ATTR amyloidosis (Grade 3) was revealed. Subsequently, the oncological diagnosis was removed. An independent disease of hematopoietic system was excluded, and mutation in TTR gene was additionally confirmed. This clinical case illustrates the possibility of making a diagnosis of cardiac amyloidosis without resorting to myocardial biopsy, when the patient still has slight limitations in physical activity (NYHA class II) and there is no late gadolinium enhancement on magnetic resonance imaging.
Ectopic adipose tissue: association of obesity phenotypes with integral metabolic indices of obesity
Authors: Podzolkov V. I. , Bragina A. E. , Rodionova Yu. N. , Osadchiy K. K. , Vasilchenko M. K. , Sizova Zh. M. , Mospanova E. V. , Litvinenko N. S. , Muradova I. D. , Akvitskaya D. V.
Published: July 2024

Aim. To study the relationship and predictive value of integral metabolic indices of obesity in the identification of ectopic obesity.

Material and methods. The study included 326 patients (146 men and 180 women, mean age 61±9 years). Anthropometric data, degree of obesity, body mass index (BMI), waist circumference (WC), sagittal abdominal diameter (SAD), body obesity index (BAI), visceral obesity index (VAI), lipid accumulation index (LAP), triglycerides-glucose index (TyG) was assessed. Perivascular adipose tissue (PVAT) volume, pericardial adipose tissue (PAT) volume and thickness of perirenal fat tissue (PRF) were assessed with CT.

Results. Patients were divided into groups: with isolated ectopic obesity (iEO) (n=17); with isolated abdominal obesity (iAO) (n=74); with EO variants: pericardial (PCO) (n=31), perivascular (PVO) (n=22) or perirenal (PRO) (n=33) with AO; with mixed ectopic obesity and AO (mEO+AO) (n=117), and patients without obesity (n=32). Significantly higher BMI, WC, SAD, and BAI indices were found in individuals with PCO+AO, PRO+AO and mEO+AO. The highest values of LAP were found in groups: PCO+AO, PVO+AO, PRO+AO. There was a correlation between ectopic fat depots and WC (r=0,62 for PAT, r=0,55 for PVAT and r=0,39 for PRF, p=0,01) and SAD (0,429, 0,329 and 0,435, respectively, p=0,01). Correlation was established between PAT, PRF and LAP (0,425 and 0,319, respectively, p=0,01). The highest AUC values>0,8 had models of WC and SAD in identification of PCO (0,801 and 0,801, respectively) and PRO (0,826 and 0,826, respectively). For PCO, the cut-off point of WC was 100,5 cm (specificity 72,9%, sensitivity 70,2%, p=0,000), SAD — 25 cm (specificity 73%, sensitivity 70,2%, p=0,000). For PRO, the cut-off of WC was 101 cm (specificity 71,4%, sensitivity 72,7%, p=0,000), SAD — 25 cm (specificity 71,4%, sensitivity 72,7%, p=0,000).

Conclusion. Еctopic fat depots are related to the risk of metabolic disorders. Potential informative value of simple and accessible integral metabolic indices was established. WC>100,5 cm, SAD>25 cm may indicate to the presence of PCO; WC>101 cm, SAD>25 cm — to the presence of PRO.
Unilateral C1-C2 Posterior Fusion in a Patient With Right Vertebral Artery Anomaly With Intracanal Trajectory
Authors: Sharma Abhinav K. , Acharya Nischal , Camino-Willhuber Gaston , Grace Kyrillos , Bhatia Nitin N.
Published: July 2024

Case:

A 59-year-old woman presented with progressively worsening neck pain and radicular symptoms. Cervical radiographs revealed C1-C2 dynamic instability. Magnetic resonance imaging and computed tomographic angiogram revealed an anomalous right vertebral artery with intracanal trajectory at C1. A unilateral left C1-C2 fusion with a C1 lateral mass screw and C2 transarticular screw placement was performed due to the anomalous artery. At 14-month follow-up, the patient's cervical symptoms had resolved.

Conclusion:

In this patient with an aberrant vertebral artery who was indicated for C1-C2 fusion, a unilateral contralateral fusion with a C1 lateral mass screw and C2 transarticular screw was a satisfactory treatment option.
Entrapment of Median Nerve After Pediatric Elbow Dislocation with a Brief Review of Literature
Authors: Domingue Grayson A. , McLaury Cameron , Pham Alexander , Ullah Raja , Chenoweth Brian
Published: July 2024

Case:

We present a case of type II (intraosseous) entrapment of the median nerve in a patient who was diagnosed based on clinical examination and magnetic resonance imaging and who was treated with medial epicondyle osteotomy, neurolysis, and transposition of the nerve to its anatomical position within a month of injury. Our patient made a complete motor and sensory recovery at 5 months with complete functionality and grip strength.

Conclusion:

Median nerve entrapment after posterolateral elbow dislocation is a rare complication with roughly 40 cases reported in the literature. This case illustrates the importance of prompt diagnosis and treatment.
Pamidronate Response in a Novel Biallelic CREB3L1 Gene Mutation–Associated Osteogenesis Imperfecta
Authors: Selina Agnes , Kandagaddala Madhavi , Madhuri Vrisha
Published: July 2024

Case:

We report a 15-year-old adolescent boy being followed up for 6 years with osteogenesis imperfecta (OI). Genetic testing of this child revealed a novel missense variant c.925C>T p.Arg309Cys in the CREB3L1 gene. Treatment with regular pamidronate therapy showed increased bone mineral density and a reduced fracture rate. His lower limb rush rodding improved his mobility. His withdrawal from bisphosphonate therapy worsened his mobility status but started improving after he restarted treatment, suggesting a response to pamidronate therapy.

Conclusion:

We report a novel biallelic missense variant c.925C>T, p.Arg309Cys, in the CREB3L1 gene causing OI, which responded to bisphosphonate therapy and corrective surgery.
Life Cycle Optimization of CO2 Huff ’n’ Puff in Shale Oil Reservoir Coupling Carbon Tax and Embedded Discrete Fracture Model
Authors: Pan Guangxuan , Wang Sen , Xu Jianchun , Feng Qihong
Published: July 2024

Amidst escalating environmental pressures, energy-intensive industries, particularly the oil and gas sector, are compelled to transition toward sustainable and low-carbon operations, adhering to the constraints of the environmental economy. While conventional reservoirs have been extensively developed, unconventional reservoirs, such as shale reservoirs, are poised to be the focal point in the future. Carbon dioxide enhanced oil recovery (CO2-EOR), a potent development tool proven effective in shale reservoirs, offers substantial carbon storage potential while significantly augmenting production. However, prior studies have solely optimized shale oil CO2-EOR production based on a singular optimization algorithm with net present value (NPV) as the objective function. In this study, we propose a novel NPV concept incorporating a carbon tax, which incorporates carbon taxes regulated by governments or organizations, thereby guiding carbon offsetting in oil reservoirs. We employ the embedded discrete fracture model (EDFM) approach to strike a balance between the accuracy of shale reservoir fracture simulation and computational efficiency, thereby enhancing timely technical guidance in the field. Subsequently, we compare the existing mainstream reservoir optimization algorithms and introduce a novel life cycle CO2 huff ’n’ puff (HnP) optimization workflow based on low-carbon NPV. The optimized NPV of the target reservoir witnessed an increase of 116.30%, while the optimization time was reduced by 89.47%, and the CO2 storage capacity was augmented by 12.58%. The workflow accelerates the simulation of the CO2 HnP in shale reservoirs, optimizing the production efficiency and CO2 storage capacity of shale reservoirs, and facilitating comprehensive and efficient production guidance for the production site.
The importance of mother-child interction on smart device usage and behavaior outcomes among toddlers: a longitudinal study
Authors: Chakranon Pairote , Huang Jian-Pei , Au Heng-Kien , Lin Chen-Li , Chen Yi-Yung , Mao Shih-Peng , Lin Wen-Yi , Zou Ming-Lun , Estinfort Wanda , Chen Yi-Hua
Published: July 2024

Background
In recent years, smart devices have become an integral part of daily life. However, longitudinal studies, particularly those regarding the relationship between toddlers’ smart device usage and behavioral outcomes, are limited. Understanding the impact of parent–child interactions on this relationship is crucial for enhancing toddlers’ developmental outcomes. Accordingly, this study examined the influence of early screen time and media content exposure on toddlers’ behaviors, as well as the positive effects of mother–child interactions on this influence.
Methods
We used relevant data related to 277 children born between November 2016 and July 2020 and who were part of an ongoing prospective follow-up study conducted across five hospitals in Taipei City, Taiwan. We analyzed (1) data from maternal reports regarding children’s behavior by using the Child Behavior Checklist (for ages 11/2–5 years), (2) assessments of mother–child interactions by using the Brigance Parent–Child Interactions Scale, and (3) self-reported parental data covering the first 3 postpartum years. Statistical analyses involved group-based trajectory modeling and multiple linear regression.
Results
A considerable increase in screen time between the ages of 1 and 3 years was associated with less favorable behavioral outcomes at age 3. These outcomes included somatic complaints [adjusted beta coefficient (aβ) = 2.17, 95% confidence interval (CI) = 0.39–3.95, p-value = 0.01], withdrawal (aβ = 2.42, 95% CI = 0.15–4.69, p-value = 0.04), and aggressive behavior (aβ = 6.53, 95% CI = 0.25–12.81, p-value = 0.04). This association was particularly evident among children with lower levels of mother–child interaction. Nevertheless, positive mother–child interactions mitigated most of the adverse effects. Additionally, increased exposure to games and cartoons was associated with poorer behavioral outcomes in all children except for those experiencing positive mother–child interactions.
Conclusion
Early mother–child interactions play a crucial role in mitigating the risk of behavioral problems in toddlers who spend prolonged periods looking at screens and who are frequently exposed to game and cartoon content.
Examining the use of complementary and alternative medicine among older persons in Ebonyi State, southeast Nigeria: a qualitative study
Authors: Agu Chibuike Innocent , Iloabachie Ugenyi Victoria , Oka Onyinyechukwu Uzoamaka , Eze Irene Ifeyinwa , Okoro Lenz Nwachinemere , Ossai Edmund Ndudi
Published: July 2024

Background: Although complementary and alternative medicine is popular among older people, there is limited understanding of its use within this subpopulation. This study aimed to explore the perceptions of older people in the communities of Ebonyi State regarding the use of complementary and alternative medicine.
Methods:Qualitative data were collected through the use of focus group discussions (FGDs), from four communities two each from urban and rural areas of Ebonyi state, Nigeria. A total of 12 FGDs involving 96 participants were conducted. A thematic analysis of data was performed with the aid of NVivo software.
Result: Almost all participants expressed a belief in the inherent benefits of complementary and alternative medicine, which were categorized into medical and non-medical reasons. Febrile illnesses, including malaria, typhoid fever, and hepatitis; respiratory; haematological; and dermatological conditions were reported as common health conditions for which participants used CAM. Additionally, participants mentioned using CAM for chronic conditions, such as diabetes mellitus, hypertension, and arthritis, as well as for health promotion and wellbeing. Preferences for CAM were influenced by beliefs in its effectiveness, perceived lower cost compared to conventional treatments, delays in hospital diagnoses and treatments, and belief in the spiritual origins of diseases. Safety concerns regarding CAM use included a lack of information on dosing, directions for safe use, and potential side effects.
Conclusion:The study findings indicate a strong belief among participants in the benefits of complementary and alternative medicine which they believe offer both medical and non-medical advantages. However, despite these perceived benefits, safety concerns were also raised by the participants. Efforts to promote education and awareness about CAM, improve access to reliable information, and ensure the safe and effective use of CAM therapies are crucial for supporting the health and well-being of older persons who choose to incorporate CAM into their healthcare practices.
Adipose mesenchymal stem cells derived exosomes ameliorates KOA cartilage damage and inflammation by activation of PINK1-mediated mitochondrial autophagy
Authors: Kang Junfeng , Jie Lishi , Fu Houyu , Zhang Lu , Lu Guozhen , Yu Likai , Tian Di , Liao Taiyang , Yin Songjiang , Xin Runlin , Wang peimin
Published: July 2024

Knee osteoarthritis (KOA) is characterized by degenerative destruction of knee cartilage. Adipose tissue-derived mesenchymal stem cells (MSCs) have been widely used in the clinic to treat joint diseases, and the exosomes secreted by adipose tissue-derived MSCs (ADSC-Exos) are more stable and easier to store than stem cell therapy alone. The aim of this study was to investigate whether ADSC-Exos could reduce KOA chondrocyte damage and inflammation by activating mitochondrial autophagy. In vitro, we induced a KOA chondrocyte model with lipopolysaccharide (LPS), and after treatment with ADSC-Exos, we assessed chondrocyte damage and inflammation by using HE, Senna O solid green, and Alcian blue staining and IL-1β immunofluorescence analysis. We also labeled chondrocytes and assessed their intracellular levels of reactive oxygen species (ROS) using the DCFH-DA probe, assessed the mitochondrial membrane potential of chondrocytes using a mitochondrial membrane potential detection kit (JC-1). In vivo, we constructed a KOA rat model by anterior cruciate ligament tenotomy (ACLT) surgery, treated the knee joint with a local injection of ADSC-Exos, reconstructed the knee joint in three dimensions using micro-CT, and evaluated the pathological changes in cartilage tissues by using HE, Senna O solid green and alcian blue staining. The in vivo and in vitro results showed that ADSC-Exos upregulated the expression of PINK1/Parkin pathway components, promoted mitochondrial autophagy in chondrocytes, increased the mitochondrial membrane potential, protected mitochondrial function in chondrocytes, and ameliorated the degradation of the cartilage matrix and inflammation during KOA.
A 24 hours changes and reactivity in heart-rate variability during the Iowa gambling task may predict Internet addiction: Weak top-down control among young students
Authors: Ono Yasuki , Soma Daiki , Hirosawa Tetsu , Sagawa Kouichi , Ogura Mototsugu , Kikuchi Mitsuru
Published: July 2024

This study evaluated the influence of excessive Internet use on heart rate variability(HRV) using a 24 hour electrocardiogram (ECG) and examined acute changes during the Iowa gambling task (IGT) and a computer game. We recruited 35 men, and divided them into high-risk Internet addiction (HIA) and low-risk Internet addiction (LIA) groups based on their Internet addiction test scores. The ECG was recorded continuously for 24 hour using a wearable sensor and during the IGT and each participant’s preferred game using a standard ECG system. Multiple psychometric tests were conducted. The HIA group exhibited more clinically significant depressive symptoms, and higher self-reported scores for anxiety, and autistic tendencies than the LIA group. Differences were observed in the 24 hour high-frequency (HF) band power and standard deviation of the normal-to-normal (SDNN) inter-beat interval between the two groups. The tendency toward Internet addiction differed by age; thus the participants were divided into two groups according to age to examine the differences between them. In the IGT, younger participants exhibited a reduced HF response. Young people’s impulse control, and the autonomic nervous system are maturing, and autonomic responses to tasks need to be assessed in an age-appropriate manner.
Aquifer Risk Management Using Swot Analysis: Strategies for Groundwater Conservation and Demand Management.
Authors: Retshedisitswe Thuto Letuka , Saheed Adeyinko Oke
Published: July 2024

The sustainability of aquifers, vital sources of freshwater, faces increasing threats due to over-extraction and contamination. This paper proposes a comprehensive approach for aquifer risk management utilizing SWOT (Strengths, Weaknesses, Opportunities, Threats) analysis in the B60D sub-catchment of the Olifants Water Management Area. By integrating this strategic framework, the study aims to delineate effective strategies for groundwater conservation and demand management. Drawing on interdisciplinary perspectives, the research examines the internal and external factors influencing aquifer sustainability, including hydrogeological characteristics, socio-economic dynamics, and regulatory frameworks. Through SWOT analysis, inherent strengths such as natural recharge mechanisms and weaknesses such as vulnerability to pollution are identified alongside opportunities like technological advancements and threats such as climate change impacts. Based on these insights, a suite of adaptive strategies is formulated, encompassing sustainable abstraction practices, land use planning, community engagement, and policy interventions. Additionally, the paper highlights the importance of stakeholder collaboration and adaptive management approaches in implementing these strategies. Case studies and empirical data are incorporated to illustrate the application and effectiveness of the proposed framework in diverse aquifer contexts. Ultimately, this research contributes to advancing aquifer sustainability by offering a structured methodology for proactive risk assessment and strategic decision-making, thereby fostering resilience in groundwater management practices.
Bioelectrical impedance vector analysis and phase angle in response to resistance training volume reduction in older women
Authors: Santos Leandro dos , Antunes Melissa , Gobbo Luís , Silva Analiza , Cunha Paolo , Kassiano Witalo , Cyrino Letícia , Nabuco Hellen , Rodrigues Ricardo , Sardinha Luis , Cyrino Edilson
Published: July 2024

BACKGROUND Bioelectrical impedance vector analysis (BIVA) and phase angle (PhA) are important for monitoring hydration, muscle function, and quality of life in older adults. Resistance training (RT) can counteract aging's adverse effects on cellular integrity and function.OBJECTIVE This study compared the effects of RT volume reduction on BIVA and PhA in physically independent older women. Sixty-seven participants (> 60 years) underwent a 20-week standardized whole-body RT program (eight exercises, three sets each, three non-consecutive days per week). They were then randomly assigned to one of three eight-week training conditions: reduced volume to one set (RV1, n = 22), two sets (RV2, n = 24), or maintained volume (MV, n = 21). Bioimpedance spectroscopy measured total body water (TBW), intracellular (ICW), and extracellular (ECW) water, BIVA, and PhA based on resistance (R), impedance (Z), reactance (Xc), and height (H). All groups showed significant increases in TBW, ICW, and ECW during the volume reduction phase (P < 0.05).RESULTS R, R/H, Z, and Z/H decreased across all groups, with significant changes from the pre-conditioning phase in the RV1 and RV2 groups (P < 0.05). Xc and Xc/H increased during the pre-conditioning phase across all groups and returned to baseline during the volume reduction phase (P < 0.05). PhA increased during the pre-conditioning and was maintained during the volume reduction phase (RV1 = + 0.33°, RV2 = + 0.50°, MV = + 0.47°; P < 0.05).CONCLUSION These results suggest that reducing RT volume by up to one-third can still improve PhA, BIVA, and hydration status in older women.
View of healthcare professionals on ultra-rapid genome sequencing and its implementation in clinical routine for critically ill children
Authors: Caillot Claire , Javouhey Etienne , HAYS Stephane , GOUY Evan , Monin Pauline , Lesca Gaetan , Sanlaville Damien , Chatron Nicolas
Published: July 2024

The clinical utility of ultra-rapid genome sequencing (urGS) in neonatal and paediatric intensive care situations has been demonstrated, and barriers to its implementation in clinical practice studied. We carried out the first study to identify the expectations of French healthcare professionals of the field. A 38 questions form was distributed via medical professional learned societies to these healthcare professionals. A hundred and sixteen responses were received: 35% from clinical geneticists, 19% from laboratory geneticists, and 32% from paediatric or neonatal intensivists. 97% respondents agreed that healthcare professionals should receive specific training before a first prescription. 94% of professionals considered urGS useful, and 97% that the result would likely modify a decision to withdraw life-sustaining treatment. A multidisciplinary validation of the urGS request was necessary for 87% of respondents, and multidisciplinary discussion of the result for 84%. Joint reporting of results by a clinical geneticist and NICU/PICU doctor was considered ideal for 91% of participants. 78% were against additional findings being reported at the same time as the result. For 99% of respondents, psychological assistance was crucial after the result. Based on our results, we propose a workflow to facilitate implementation in a maximum of centers.
Thermal Management of Power Modules Based on the Hybrid Cooling System: Phase Change Material with Coolant Fluid
Authors: elmi ehsan abdi , Lavasani arash Mirabdolah , Dinarvand Saeed , Nimafar Mohammad
Published: July 2024

Keeping the operating temperature in the allowable range of the power module, under a very high heat flux, is of particular importance in the performance of the systems and their reliability. In this investigation, as a new approach, a new hybrid thermal heat sink consisting of phase change material with different arrangement and mass flow rates has been used for cooling an Insulatedgate bipolar transistor. As an innovation, to reduce the operating temperature of the power module at a heat flux of 100 W/cm2, the paraffin and Metal-based PCM have been applied in the water cooling chamber and simulated simultaneously. The finite volume method and piezo algorithm was used to solve the governing equations. Then, the effect of the flow rate and arrangement of PCMs on temperature variations of the power module has been examined in terms of time. The melting process of the PCM was numerically simulated by the enthalpy-porosity method in threedimensional computational domain. The results revealed that using the metal-based PCM compared to paraffin due to its high thermal conductivity increased the heat transfer rate. As a result, the operating temperature of the power module decreased. Also, metal-based PCM in 4 different arrangements (A,B,C,D) performs better than the conventional cooling system. Finally, it reduced the operating temperature of the power module. Based on the results obtained at flow rates of 0.0025, 0.00375, and 0.005 kg/s, arrangement Case D showed the best performance by reducing 3 °C compared to the pure working fluid in the power module.