bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of edapho-climatic factors on the content, quality and efficiency of secondary metabolites in the type species Aristolochia longa L
Authors: BELDI Hakima , Khodja esma anissa Trad , HAMIDA Bahaedine , BELATAR Hakima , BOUDECHICHA Amel , BENSOUICI Chawki , ERENLER Ramazan , CHORFI Zineb
Published: June 2023

Many commercial pharmaceutical drugs and herbal remedies derived from medicinal plants rely on these metabolites. In this study, we investigated the influence of climatic factors and soil composition on the quantity, quality and efficiency of phenolic compounds in the typical species Aristolochia longa L. from three stations in eastern Algeria, each of which is located in a different bioclimatic stage.To characterize the chemical profile of crude methanolic extracts of three parts of Aristolochia longa L. from three different regions using liquid chromatography-mass spectrometry (LC-MS) analysis, also, their biological and pharmacological properties were evaluated: the antioxidant capacities (DPPH., ABTS−+, CUPRAC, FRAP, β-carotene-linoleic acid bleaching assays, ability to inhibit enzymes against acetylcholinesterase (AChE) and buthyrylcholinesterase (BChE)]. Secondary metabolites were extracted from leaves, stems and roots of Aristolochia longa L. The amount of polyphenols, flavonoids, flavones and flavonols were determined by colorimetric method. Various in vitro biochemical tests were performed to evaluate the antioxidant and free radical scavenging properties, the neuroprotective abilities of different extract were examined against the acetylcholinesterase and buthyrylcholinesterase enzymes. The components of the active extracts were identified by LC-MS and compared to reference substances. The antibacterial activity was evaluated using the agar disk diffusion method on reference strains of ATCC types. The results showed that Aristolochia longa L. extracts had strong antioxidant activity in all assays and a strong inhibitory effect against AChE and BChE enzymes, as well as antibacterial capacities against different strains. LC-MS analysis revealed the presence of eight phenolic compounds in methanolic extract of Aristolochia longa L. from leaves: apigenin, diosmin, quercetin, quercetine-3-glycoside, apigenin 7-O glycoside, rutin, neohesperidin and taxifolin. This work revealed significant differences in the yield sand chemical composition of leaves of Aristolochia longa L., collected from three locations in Algeria. Although the main components of the all extracts of leaves are common, however, their percentages are different. Furthermore, our study demonstrates a high variation in biological activity potentials according to parts of species and populations. This point out the importance of the geographic origin of the populations and the growing conditions which could significantly affect the composition and their biological activities.
A simple, quick and economic method for in vitro cultivation of Echinococcus multilocularis metacestode and generation of primary cells
Authors: Zhang Cuiying , Li Zihua , Yong Fu , Li Tao , Hou Siyu , Wang Chan , Li Ming , Zhao Wei
Published: June 2023

Background Alveolar echinococcosis is considered to be one of the most potentially lethal parasitic zoonotic diseases. However, the molecular mechanisms by which Echinococcus multilocularis interact with host are poorly understood and only limited treatments available. Due to the great advantages of cell culture systems for molecular research, numerous attempts have been made to establish primary cell cultures for Echinococcus multilocularis. In this study, we developed a simple, rapid and economic method, which allows Echinococcus multilocularis metacestodes tissue blocks to generate daughter vesicles without the presence of host feeder cells in regular medium.
Methods We performed anaerobic, hypoxic (1% O2), normoxic and semi-anaerobic (in sealed tubes) cultures for Echinococcus multilocularis metacestodes tissues to produce daughter vesicles. Then the daughter vesicles were cultured at three distinct oxygen consentrations (anaerobic, 1% O2, normoxic) to search optimal cultivation conditons. The daughter vesicle’s viability was assayed by carboxyfluorescein succinimidyl ester staining. These vesicles with good vigor were subsequently used for testing antiparasitic effect of albendazole, isolating primary cells and infecting animals.
Results After 4 weeks incubation, we found that Echinococcus multilocularis metacestodes tissues only cultured in sealed tubes produced daughter vesicles. And the daughter vesicles were observed remarkably enlarged under anaerobic conditions after 8 days of culture, while vesicles cultured under other two conditions showed a mild increase in volume. Our in vitro cultivated vesicles had good viability and can be used for testing of antiparasitic drugs, isolating primary cells and infecting animals.
Conclusions In the present work we established a simple, quick and economic method for in vitro generation vesicles from tissue blocks of Echinococcus multilocularis metacestodes in the absence of host feeder cells. Our in vitro cultivated vesicles with good viability are suitable for screening drugs for treatment of alveolar echinococcosis in vitro and in vivo.
Comparison of clinical characteristics and outcomes in primary neuroendocrine breast carcinoma versus invasive ductal carcinoma
Authors: Peng Li , Ma Mingwei , Zhao Dachun , Zhao Jialin , Mao Feng , Sun Qiang
Published: June 2023

Background
Neuroendocrine breast carcinoma (NEBC) is a rare special histologic type of breast cancer. Information on the clinical outcomes of NEBC patients remains scant, with only some small sample studies documenting contradictory results.
Methods
We conducted a retrospective case‒control study of clinical characteristics and outcomes among patients with primary NEBC (pNEBC) versus invasive carcinoma of no special type (NST) between November 2004 and November 2017 in the Peking Union Medical College Hospital, Beijing. NST patients were strictly matched 1:4 during the same period based on TNM stage. Statistical comparisons were performed to determine the differences in survival between NST and pNEBC patients and to identify clinical factors that correlate with prognosis.
Results
A total of 121 participants affected by pNEBC were included in our analysis from November 2004 to November 2017. Elderly persons (>60 years of age) were more likely to have pNEBC than young persons (p=0.001). In addition, pNEBC patients had significantly higher odds of having tumors 2-5 cm (36.5%) and >5 cm (6.1%) in size than NST patients. Despite a significant difference in tumor size, the proportion of patients with lymphatic metastasis showed no difference between the two groups(p=0.021). In addition, the rate of patients with ER-negative tumors in the pNEBC group (4.2%) was significantly lower than that in the NST group (29.8%). Significant differences were noted in the PR-negative (13.3% versus 36.6%, P<0.001) and HER2-negative (90.5% versus 76.4%, P=0.001) expression statuses among these patients. Of 121 pNEBC patients, 11 (9.1%) experienced relapses during the follow-up period. We found that tumor size was an independent risk factor for relapse. For hormone receptors on tumor cells, ER-positive breast cancer patients had significantly lower odds of relapse than receptor-negative patients.
Conclusions
Our data demonstrate that there is no significant difference in mortality and relapse between the pNEBC and NST groups. The tumor size in the pNEBC group wassignificantly larger than that in the NST group. In addition, the absence of ER independently increased the relapse rate for breast carcinoma patients.
The Ramification of Teachers’ Socio-Demographic Attributes on Their Self-Efficacious Beliefs Responding to United Nations Sustainable Development Goal 3 “Well-Being”: A Fact-Finding Study
Authors: Hassan Mehboob Ul
Published: June 2023

After replacing Millennium Development Goals, the United Nations unveiled 17 integrated and indivisible Sustainable Development Goals in September 2015 with the extension of 169 targets to enhance harmony, prosperity, lifelong learning, and well-being around the globe. To implement the global agenda in any state, educational institutions are important places where teachers are considered the backbone and important figures. They enthusiastically, energetically, dynamically, and vigorously work to meet global standards through their hidden potential. Focusing on teachers’ socio-demographic attributes, the current research was planned to find out that male and female teachers working in rural and urban schools with different ages, teaching experiences, academic and professional qualifications, and the nature of jobs with self-efficacious beliefs are promoting well-being (SDGs 3). The researchers planned quantitative research on a sample of 637 participants working in public-sector educational institutions. After obtaining unfetter and unrestricted permission from the authors, a standardized instrument reinforced the researchers to collect the data from respondents. After ensuring ethical considerations, piloting the instrument, and confirming Cronbach’s Alpha statistics, the use of parametric reported that teachers’ socio-demographic attributes have a 54.50% effect on their self-efficacious beliefs and put a 64.50 % effect on prioritizing UN, SDG goal 3; well-being. In Pakistan, SDG implementation is less emphasized, especially in the Schools’ Education Departments. Based on the results, the researchers recommend that teachers’ training institutions and District Education Authorities may take necessary action to train teachers on SDGs’ global agenda emphasizing well-being.
WITHDRAWN: Development and thermophysical investigation of stable fatty acid/SiO2 composite microcapsules through interfacial polycondensation
Authors: Veerakumar  , Cho Honghyun
Published: June 2023

Developing highly capable energy storage materials is crucial for efficient thermal energy storage and utilization. Microencapsulated lauryl alcohol (LA) as phase change material (PCM) using SiO2 shell was prepared through a novel one-pot synthesis of interfacial polycondensation using tetraethyl orthosilicate (TEOS) as shell precursor. The chemical composition of the microcapsules was examined through Fourier transforms infrared spectroscopy (FT-IR). The thermal properties were analyzed through differential scanning calorimetry (DSC), which reveals that the melting and freezing points of microcapsules were 23 oC and 18.9 oC, respectively. For melting and freezing, the estimated latent heats were 90 Jg− 1 and 88.2 Jg− 1, respectively. Thermogravimetric (TG) analysis confirms that the microcapsules are stable at a higher temperature. Besides, the leak test of the developed microcapsules was performed to investigate the stability during the melting process. Moreover, the prepared microcapsules (MPCM2) show stable and excellent thermophysical properties after 500 thermal cycles, which shows that the developed microcapsule is an ideal candidate for thermal energy storage.
Viruses of nitrogen-fixing Mesorhizobium bacteria in globally distributed chickpea root nodules
Authors: Matsumoto Brandon , Greenlon Alex , Perilla-Henao Laura , Horst Anneliek ter , Geonczy Sara , Cook Douglas , Emerson Joanne , Sieradzki Ella
Published: June 2023

Legume nodules are specialized environments on plant roots that are generated and dominated by nitrogen-fixing bacteria. Bacteriophages (phages) in these nodules could potentially provide top-down controls on population size and, therefore, function of nitrogen-fixing symbionts. Here we sought to characterize the diversity and biogeographical patterns of phages that infect nitrogen-fixing Mesorhizobium symbionts in root nodules, leveraging 197 genomes of Mesorhizobium isolated from nodules and 648 nodule metagenomes collected from three species of chickpea plants (Cicer spp.) under different agricultural management practices, spanning eight countries on five continents. We identified 106 phage populations (vOTUs) in Mesorhizobium draft genomes, 37% of which were confirmed as likely prophages. These vOTUs were detected in 64% of the Mesorhizobium-dominated nodule metagenomes and 58% of Mesorhizobium isolates. Per metagenome, 1-16 putative Mesorhizobium vOTUs were detected, with over half of the nodules containing only one such vOTU. The majority of vOTUs were detected exclusively in Ethiopia, followed by India and Morocco, with the lowest richness of putative Mesorhizobium phages in countries that applied industrial Mesorhizobium inoculants to crops. Two vOTUs were identified in five or more countries and in nodules dominated by different strains of Mesorhizobium, suggesting infection of diverse Mesorhizobium hosts and long-term interactions in root nodules. Beta-diversity of these Mesorhizobium phage assemblages was significantly correlated with the dominant Mesorhizobium strain, but not with measured environmental parameters. Our findings indicate that nitrogen-fixing nodules in chickpea plants can contain distinct viral assemblages, with potential impacts on the nodule microbiome that bear further exploration.
Quantum Fisher information of an N-qubit maximal sliced state in decoherence channels and Ising-type interacting model
Authors: Li Yan , Ren Zhihong
Published: June 2023

Various quantum states have been suggested to realize high-precision measurement and quantum Fisher information (QFI) is one of the most important indicators to evaluate the performance. Here, we systematically investigate the QFI of an N-qubit maximal sliced (MS) state in different environments. In the ideal situation, we present the analytical QFI and it decays from N2 to (N − 1)2 as the parameter α changed from 0 to 1, which denotes the decreased metrological ability. In the amplitude damping channel, the variation trends of QFI with respect to p are similar and it decreases to the number of qubits N at p = 1, meaning the vanished entanglement superiority. However, it is different in the phase damping channel where with the increase of the number of qubits a turning point of QFI equal to N is found at p closing to 0.1. In the Ising-type interacting model, with the increasing interaction strength γ, the QFI with respect to α shows a crossover from decreasing to increasing. Particularly, at the critical point γ = 1, the QFI of an N-qubit MS state is found analytically equal to N2 and regardless of α. This indicates a great potential in achieving the Heisenberg-limited metrology and may shed some new light on quantum information science.
PACS: 03.67.-a, 03.65.Ud
Incomplete filling of spray-dried K2EDTA evacuated blood tubes: impact on measuring routine hematological parameters on Sysmex XN-10
Authors: Lippi Giuseppe , Dima Francesco , Tosi Marco , Carpenè Giovanni , Celegon Giovanni , Favaloro Emmanuel J. , Salvagno Gian Luca
Published: June 2023

Background. Because there is little published evidence on the effects of incomplete filling of K2EDTA evacuated blood tubes on routine hematological testing, this original study aimed to provide updated information on this preanalytical aspect.
Materials and Methods. The study population consisted of 17 ostensibly healthy volunteers. Blood was drawn by venipuncture with a 10 mL syringe and dispensed in varying amounts (0.2, 0.5, 1.0, 2.0, and 3.0 ml) into 3.0 mL blood tubes containing spray-dried 5.4 mg K2EDTA. All tubes were gently mixed and used to perform routine hematology tests on the Sysmex XN-10. Clinically significant variations were defined when the limits of desirable specifications of bias derived from biologic variation were exceeded.
Results. The desirable bias was exceeded in 33% filled tubes (1.0 mL) for hematocrit and MCV (increased values) and for MCHC (decreased values), while it was exceeded in 17% filled tubes (0.5 mL) for hemoglobin, hematocrit and MCV (increased values), and for MCHC (decreased values). Finally, the variation of values was higher than the desirable bias for RBC, hemoglobin, hematocrit and MCV (increase), and for MCHC and MPV (decrease) in 7% filled tubes (0.2 mL). No clinically significant variations were observed in tubes filled up to 67% of their nominal volume (i.e., 2.0 mL).
Conclusions. Consideration should be given to reject spray-dried K2EDTA blood tubes that contain a blood volume < 67% of the nominal fill volume, as biased laboratory data in these samples may interfere with clinical decision making and care management.
Ideologia do consumismo e dados digitais na ordem mundial contemporânea
Authors: Moura Stéfano , Milan Marcelo
Published: June 2023

Discute-se a ideologia do consumismo e sua manifestação na ordem mundial contemporânea, marcada por transferências de dados digitais (big data). Argumenta-se que tal ideologia cumpre papel central na atualidade, naturalizando o ato de consumir através de sua ferramenta de influência clássica, o anúncio, o qual está potencializado pelas tecnologias usadas pelas empresas transnacionais de dados. Como esse consumo massificado reforça processos hegemônicos social e ambientalmente regressivos, mobiliza-se o método das estruturas históricas de Cox para apresentação de uma proposta contra-hegemônica à estrutura vinculada à ideologia do consumismo.
Destruindo pontes
Authors: Buarque Daniel
Published: June 2023

A política externa brasileira tem a histórica ambição de aumentar o prestígio do país. Status,no entanto, não depende apenas da aspiração, mas de como um estado é percebido pelosoutros. Este artigo analisa as percepções estrangeiras sobre a busca por status do Brasile contrasta com a diplomacia do governo Bolsonaro. Baseia-se em uma análise temáticareflexiva de dados primários de 94 entrevistas com a comunidade de política externa degrandes potências. O artigo argumenta que Bolsonaro corroeu os principais caminhosque as nações poderosas veem como servindo para a construção e expansão do prestígiointernacional do Brasil.
Prediction error analysis for intelligent management and predictive diagnostics systems
Authors: Baranov L. A. , Balakina E. P. , Zhang Yungqiang
Published: June 2023

Random signal prediction is efficient for intelligent management and predictive diagnostics systems.Aim.The paper aims to analyse the error of random signal prediction. To develop recommendations for the selection of random signal extrapolator parameters.Methods. The paper uses the mathematics of the theory of random functions, formalization adopted in the theory of pulse systems, mathematical description of extrapolators with Chebyshev polynomials orthogonal over a set of equally spaced points. The coefficients of the predicting polynomial are selected according to the minimal least squares.Results.The paper describes the mathematical model of the extrapolator. Design ratios were obtained for prediction error assessments. The maximum and prediction interval-averaged relative mean square error of extrapolation were defined. The authors analyse the error of extrapolation of random processes defined by the sum of a centred stationary random process and a deterministic time function. Based on diverse calculations, recommendations were defined that allow selecting the parameters of the extrapolator (degree of the extrapolating polynomial, number of test points that precede the prediction interval, discretisation interval of the predicting function) under the specified input signal models.Conclusion.The use of extrapolators based on Chebyshev polynomials orthogonal on a set of equally spaced points and the least square method allows implementing a procedure for calculating predicted values of a random process with the required accuracy. Under the specified models of the predicting signal, a method was developed that allows selecting the extrapolator’s parameters (order, number of points involved in the generation of the prediction, sample spacing) for the purpose of ensuring the required accuracy.
Common cause failures: definitions and typical errors
Authors: Netes V. A.
Published: June 2023

The Aim of the paper is to analyse the definitions of the term “common cause failures” given in various international and Russian standards and point out their shortcomings; to identify and analyse the typical errors in the use of this notion and consideration of such failures as part of system dependability calculation. The importance of the topic is due to the fact that such failures reduce the efficiency of redundancy and must be taken into account in the process of the design of systems with high dependability requirements. Methods. The paper provides a comparative analysis of the definition of common cause failures given in Russian and international standards; analyses the methods of taking into account the effect of such failures presented in various publications; uses methods of the probability theory. Results. Differences between standards were identified in terms of the definition of the term “common cause failure”, as well as shortcomings of such definitions. Typical errors were pointed out in some publications dedicated to the methods of taking such failures into consideration. The simplest and most common beta-factor model was considered in most detail, the limits of its application were pointed out. Conclusions. It is advisable to use a single definition of common cause failures in different standards. It is to be taken from the basic terminological dependability standard with an appropriate reference. In the term itself and its definition, the word “failures” is to be in plural. The definition of this term in GOST EN 1070-2003 and GOST 34332.3-2021 are wrong, as they in no way correspond to the content of the defined notion. The conventional beta-factor model intended for taking into account common cause failures in the process of failure probability calculation can only be used in case of such probabilities being low.
Method for designing and developing space mechanisms with specified dependability
Authors: Pokhabov Yu. P.
Published: June 2023

Aim. According to the established concept of space launch, practically each of the spacecraft in a near-Earth orbit needs to separate from the launch vehicle and deploy its folded structures (solar panels, antennas, reflectors, rods, etc.) in the operational position and only then is able to become fully functional for its intended purpose. The reliability requirements for single-operation mechanisms are so high, that any unidentified potential threat of critical failure in the course of design, development, manufacture and operation may make the creation of such spacecraft pointless, which is confirmed by the fatal results of the missions of the Sinosat- 2, Ekspress-АМ4, Kanopus-ST, Zuma, Chinasat-18 and many other satellites and space objects. The design of space mechanisms with a specified dependability is complicated by the fact that practically all of them are unique, highly critical systems that are supposed to be as reliable as possible, are unique or rare in terms of their design, are manufactured at most in small series and operate in unique environments. Statistical data on the dependability of components and elements of mechanisms that operate in the open space environment is at best insufficient for obtaining reliable dependability calculation results using the statistical methods of the modern dependability theory, while at worst they do not exist at all. In the context of constantly growing complexity of space technology and increasing costs of any in-orbit failure there is an objective necessity for developing a method for designing space mechanisms based on the evaluation of the specified dependability using the engineering solutions (without involving statistical methods of dependability) and early failure prevention procedures. Methods. The paper presents a method for designing and developing space mechanisms based on the design engineering analysis of dependability. Results. The method proposed in the paper allows modifying the analytical verification toolkit, thus migrating from design and expert methods (e.g., Stage-Gate or FMEA) of product design to purely engineering ones that are based on engineering disciplines and design engineering methods of ensuring quality and dependability. The use of design engineering analysis of dependability as part of the design and development enables dependability assurance as a natural and integral part of a designer’s work that enables engineering decision-making in accordance with the specified dependability requirements (rather than in an isolated manner).
Evaluation of customer orientated indices and reliability study of electrical feeder system
Authors: Tiwary Aditya , Tiwary Swati
Published: June 2023

Aim.Reliability evaluation of a system or component or element is very important in order to predict its availability and other relevant indices. Reliability is the parameter which tells about the availability of the system under proper working conditions for a given period of time. The study of different reliability indices are very important considering the complex and uncertain nature of the power system.Methods.The study uses classical methods of the reliability theory in respect to a system with a constant failure rate consisting of series-connected elements.Conclusions.The paper reviews literature dedicated to the reliability estimation of power supply systems. In particular, the paper examined studies that employed the Markov cut-set approach, the conditional probability approach, distribution systems simulation, probabilistic models, the Monte Carlo method, reliability network equivalent, state transition sampling, inspection repair-based availability optimisation of distribution systems, bootstrapping, fault tree analysis, Bayes networks, peak-valley partition model, demand response model, etc. The authors defined the problem and analysed input data. They showed that, in physical terms, the system configuration will be a series reliability network. Given the above, the system fails even if one component fails, and survives if all of the components survive. It is noted that, when considering the reliability of series systems, the three basic parameters are average failure rate, average annual outage time and average repair time. As the customer orientated indices associated with the research of operational reliability the system average interruption frequency index (SAIFI), the system average interruption duration index (SAIDI) and the customer average interruption duration index (CAIDI) were used. Using the example of an eight-node radial distribution system, reliability was estimated for each distribution section, as well, as at each load point. For the examined distribution sections and load points, three basic reliability parameters were also obtained, i.e., the average failure rate, average outage time and average annual outage time. For a radial distribution system, important customer-oriented indices were estimated, i.e., system average interruption frequency index, system average interruption duration index and customer average interruption duration index. The resultant data allow characterizing reliability and other associated indices, which is relevant for power distribution systems.
PANORAMA DA ADOÇÃO DE INCENTIVOS FISCAIS PARA PROMOVER DESENVOLVIMENTO DE SETORES ECONÔMICOS COM FOCO NA INOVAÇÃO:
Authors: Pereira Valadão Marcos Aurélio , Ferreira da Paixão Bruno , Miranda Tabak Benjamin , Angelotti Meira Liziane , Teodorovicz Jeferson
Published: June 2023

Este artigo investiga a revisão da literatura relativa ao uso de incentivos ficais para promover o desenvolvimento de setores econômicos com foco na inovação.  Por meio de pesquisas estruturadas em bases de dados, aplicando-se análise bibliométrica com abordagem qualitativa e quantitativa, foi possível coletar artigos que tratam do tema identificando os principais autores, como abordam o tema e as principais aplicações nos casos estudados. Além disso, com ao auxílio de técnicas de processamento de textos, foi possível identificar as relações entre os temas de incentivos ficais e seu impacto na inovação.  Dessa forma, o presente trabalho se insere em um projeto de pesquisa que tem por objetivo analisar os benefícios fiscais e os incentivos que possam fomentar a inovação.
MODELO DE TRANSFERÊNCIA DE TECNOLOGIA VERDE NO ÂMBITO UNIVERSIDADE-INDÚSTRIA
Authors: Santos Silva Luan Carlos , Ten Caten Carla  Schwengber , Gaia Silvia
Published: June 2023

O objetivo do artigo consistiu em desenvolver um modelo conceitual de transferência de tecnologia verde no âmbito universidade-indústria. A pesquisa por sua natureza constitui-se como aplicada. Do ponto de vista dos objetivos constitui-se como descritiva e exploratória, sendo uma abordagem foi qualitativa. Os procedimentos metodológicos ocorrem em quatro fases. A primeira fase consistiu em prospectar na literatura internacional os modelos conceituais de transferência de tecnologia, a revisão foi feita através da plataforma ISI (Web of Science) e baseada em artigos publicados em um período de 20 anos. A segunda fase consistiu no desenvolvimento da cadeia de valor. A terceira fase consistiu na aplicação de um questionário com perguntas abertas universidades brasileiras. Por fim, a quarta fase consistiu no desenvolvimento do modelo conceitual e sua validação com grupos focais. Como resultados, por meio do modelo desenvolvido, foi possível integrar atividades de pré-transferência, desenvolvimento e pós-transferência de tecnologia. Buscou-se ampliar o modelo com relação aos que existem na literatura internacional. Contudo, o processo de transferência de tecnologia pode realizado enfocando nos resultados comerciais do licenciamento da tecnologia, incluindo as vantagens comerciais do foco sustentável. O governo brasileiro deve criar políticas públicas que visem estimular a participação de empresas nas universidades, possibilitando estimular os laboratórios das universidades a desenvolver tecnologias que se enquadrem como Tecnologias/Patentes Verdes.
REDES SOCIAIS COMO ESPAÇO DE MEMÓRIA
Authors: Pereira Ione dos Santos , GOMES PRISCILA
Published: June 2023

O presente artigo é fruto de trabalho de conclusão de curso de Arquivologia. A pesquisa observou grupos de comunidades escolares formados no facebook, que postam registros particulares e individuais voltados ao universo das instituições de ensino pelas quais os integrantes dos grupos passaram. Verificou-se que tais registros ao serem compartilhados atingem uma memória coletiva por parte dos sujeitos que frequentaram em determinado período, o espaço escolar, evidenciando o quanto o facebook se constitui como um lugar de memória, justificada, inclusive, em alguns casos, pela ausência desse tipo de acervo sob posse da instituição de ensino. Para tanto, tal estudo se concentrou em pesquisar dois grupos do facebook, com ênfase nas postagens e interação de seus usuários diante de um documento escolar, sendo feito um recorte nos anos em que foram feitas as postagens. De cada grupo, foi analisada uma postagem anual compreendendo os períodos de 2019 à 2022.
CIÊNCIA DA INFORMAÇÃO EVOCA A EDUCAÇÃO AMBIENTAL?
Authors: Souza dos Santos Patrícia , Moraes Margarete Farias de , Miguel Marcelo Calderari
Published: June 2023

A Educação Ambiental é um processo imprescindível na cena e no debate nacional e internacional que envolve a Ciência da Informação. O  estudo consiste em estabelecer um painel métrico da informação, recorrendo ao acervo de publicações periódicas BRAPCI e diante o acervo de publicações situa-se elementos da abrangência temática acerca educação ambiental. Como metodologia, a pesquisa caracteriza-se como descritiva e bibliométrica e compreende o período de 2012 a 2021 de comunicações científicas indexadas no acervo de publicações em ciência da informação. Os resultados destaca o levantamento de 21artigos em 12 revistas científicas diversas e, os anos mais produtivos são 2014 e 2018; ambos com quatro itens documentais indexados. Conclui-se que a Educação Ambiental se mantém na embrionária pauta da literatura científica da ciência da informação, tangenciando construtos interdisciplinares em torno da sustentabilidade, educação em saúde, ecojornalismo, políticas públicas, responsabilidade social e tecnologia social.
DFT, Molecular Docking, Bioactivity and ADME Analyses of Vic-dioxim
Ligand Containing Hydrazone Group and its Zn(II) Complex
Authors: Gökçe Çalişkan Şerife
Published: June 2023

Background:

Cancer is one of the diseases affecting a large population worldwide and
resulting in death. Finding new anti-cancer drugs that are target-focused and have low toxicity is
of great importance.

Objective:

This study aimed to investigate the effects of vic-dioxime derivatives carrying hydrazone
group and its Zn(II) complex on cancer using molecular docking, bioactivity and quantum
chemical calculations.

Methods:

Molecular docking studies were performed on epidermal growth factor receptor and
vascular endothelial growth factor receptor 2 target proteins. Furthermore, molecular geometry
was performed, and the frontier molecular orbitals, Mulliken charges and molecular electron density
distribution were evaluated using density functional theory. Also, the bioactivity parameters
of the compounds were evaluated, and ADME analysis was performed using web-based tools.

Results:

Higher binding affinity was observed for Zn(II) complex with target proteins vascular
endothelial growth factor receptor 2 and against epidermal growth factor receptor when compared
with LH2. Only the Zn(II) complex against the epidermal growth factor receptor had ligand efficiency
and fit quality in the valid range. Furthermore, LH2 has the most potent electrophilic ability
(acceptor) among other compounds. Moreover, both LH2 and Zn(II) complexes strongly satisfy
Lipinski’s rule of five.

Conclusion:

In conclusion, these novel compounds, especially Zn(II) complex, can be new candidates
for anticancer drug development studies which are target-focused and have low toxicity.
Applications of Emerging Nanomaterials and Nanotechnology
Authors: Singh N.B.
Published: June 2023

The book reviews recent developments in the field of nanomaterials science and technology. Topics covered include methods of fabrication of nanomaterials and nanocomposites, and their applications in areas such as Optoelectronics, Cosmetics, Energy Conversion Cells, Soil and Water Treatment, Agricultural Engineering, Food Sciences, Leather Production, and Photocatalysis.
Los chalets como patrimonio agroindustrial: Las viviendas del azúcar en Tumán (Lambayeque, Perú)
Authors: Marchena Tafur Aurora , Palma Urcia Josías , Torres Loyola Elmer , Takayama Bravo Edgardo , Terán Flores Carlos
Published: June 2023

La presente investigación analiza las viviendas chalets de Tumán, desde lo patrimonial, con el objetivo de comprender sus valores patrimoniales, desde la perspectiva de sus actores sociales, sobre la base de una metodología cualitativa y con un diseño fenomenológico, definiendo el objeto, los sujetos y el lugar. Los análisis realizados están basados en la información obtenida en campo, a través de entrevistas presenciales y virtuales. Además, cabe mencionar que el relevamiento de la información se realizó in situ, midiendo, tomando fotografías y sobrevolando el lugar de estudio, teniendo como resultado que el objeto presenta diversas estimaciones por parte de sus sujetos, existiendo una predominancia y hasta ausencia de valores. Finalmente, concluimos que es importante la participación de los actores sociales como sujetos patrimoniales, pues son ellos quienes determinan los valores que posee el objeto, comprendiendo en tal sentido que el valor de un objeto patrimonial no es intrínseco, sino extrínseco.
Conservación de Cajamarquilla por Albert Giesecke, un análisis comparativo con las actividades restaurativas en Pachacamac 1938
Authors: Asencios Lindo Rodolfo
Published: June 2023

Cajamarquilla, un importante complejo arqueológico ubicado al Este de Lima. Cuenta con una ocupación desde el Intermedio Temprano (200-600 d.C) al Intermedio Tardío (900-1440 d.C). Ha sido objeto de diversas investigaciones arqueológicas desde inicios del siglo XX a la actualidad; sin embargo, pese a numerosos estudios, se desconocen la conservación realizada por Albert Giesecke en 1938, realizado en paralelo en Pachacamac en sur oeste de Lima. El presente estudio busca describir las actividades y nivel de intervención en Cajamarquilla con respecto a Pachacamac, mediante la revisión de información inédita de archivo, publicaciones, registro fotográfico se explora el estado de conservación y las actividades realizadas, para posteriormente analizarlo comparativamente dichas actividades. Esto concluye que, si bien se presenta similitudes en la actuación de Giesecke, en el aspecto político, técnico-metodológico y de gestión, la conservación de Cajamarquilla fue menos complejas debido a su estado de conservación, ubicación geográfica y conocimiento histórico; en tanto que Pachacamac, su cercanía costera, agentes de deterioro marino y estudios científicos permitieron demandaron mayores actividades conservativas. Este estudio apertura la búsqueda de otras intervenciones arqueológicas, que permitan comprender su proceso histórico, teórico, metodológico y técnico de la conservación de los monumentos prehispánicos en el Perú.
Olimpia Niglio Soriente
Authors: Hayakawa Casas José
Published: June 2023

Olimpia Niglio, italiana, doctora en Restauración de la Arquitectura, profesora permanente de Restauración de la Arquitectura comparada en la Facultad de Ingenieria de la Universidad de Pavia (Italia) desde el 2022. Ha iniciado sus actividades académicas en el 2001 en la Universidad de Pisa (Italia) y desde el 2006 se mudó a Colombia, primero en la Universidad de Ibagué y después en la Universidad de Bogotá Jorge Tadeo Lozano. Desde el 2011 ha sido profesora permanente en Japón en la Universidad de Kyoto, después en la Universidad de Hokkaido y en la Hosei University en Tokyo, hasta todo el 2021. Es ganadora de becas internacionales y premios por su trayectoria científica.
Emotional Heritage. Visitor Engagement at Museums and Heritage Sites
Authors: Balarezo Alberca Giovanna
Published: June 2023

Este meritorio libro explora el valor que ejercen las emociones en las personas cuando visitan los museos y sitios patrimoniales. La investigación se realiza sobre la base de 4,502 entrevistas cualitativas realizadas a visitantes de 45 museos y lugares históricos de valor patrimonial en Australia, Estados Unidos e Inglaterra. Este estudio, que recopila una gran cantidad de datos de manera sistemática y sostenida (2004, 2007 y 2010-2013), tiene tres temas centrales: entender los procesos de valorización patrimonial, conocer la forma que los visitantes utilizan los sitios e identificar las consecuencias sociales que estos podrían tener. La autora sitúa al visitante en el centro de la discusión. Para ella, los visitantes no son un público pasivo, sino al contrario “son socios y cocreadores de los significados históricos y contemporáneos que poseen los sitios patrimoniales” (Smith, 2020, p. 307), los cuales describe como "teatros de la memoria y lugares de creación de patrimonio" (p. 305).
Hacienda Maranga como patrimonio agroindustrial de San Miguel
Authors: Avila Espichán Soveyda
Published: June 2023

El patrimonio agroindustrial es un tema recientemente explorado en Latinoamérica, en donde nuevas investigaciones están demostrando su importancia en el campo patrimonial. El objetivo de esta investigación es develar lo relevante que es la presencia de patrimonio agroindustrial, probablemente el único caso de estudio de este tipo en el distrito de San Miguel al día de hoy: la Hacienda Maranga; su historia, sus actores a través del tiempo, los objetos y valores patrimoniales que le atribuyen. Esta peculiar hacienda significo un hito en diferentes momentos de su historia, la importancia e influencia en la conformación del distrito san miguelino podría ser incluso causa de su presencia.
Escuela Nacional Superior Autónoma de Bellas Artes del Perú. Patrimonio cultural de la Escuela Nacional Superior Autónoma de Bellas Artes del Perú
Authors: Anchante Bautista Angela
Published: June 2023

Esta publicación aborda la larga y rica tradición artística y cultural, heredada por la escuela quien en su inicio influenció fuertemente el pensamiento y la vida Nacional. Comprende patrimonio mueble e inmueble que datan de la época virreinal, del siglo XIX, del siglo XX y obras contemporáneas. Está compuesta por cuatro capítulos, que contemplan todo el patrimonio que posee la institución.
Arquitectura & urbanismo contemporáneo en centros históricos
Authors: Ravines Casas Jonathan
Published: June 2023

Los centros históricos de las ciudades latinoamericanas comparten, además de un legado histórico vinculado a la época virreinal, un conjunto de fenómenos urbanos que se manifiestan en su deterioro físico y social. El despoblamiento urbano, la precarización y tugurización de la vivienda, la pérdida de inmuebles de valor patrimonial, la fragmentación del tejido urbano son en muchas áreas centrales causa de su obsolescencia, a la vez que motivo de estudio y análisis por profesionales que buscan comprender y proponer acciones desde la arquitectura y urbanismo contemporáneo para poder cambiar el devenir de las ciudades patrimoniales.
Tipón: obra maestra de ingeniería hidráulica del imperio de los incas
Authors: Peña Guillen Victor
Published: June 2023

Kenneth Wright, aborda la descripción de Tipón en el sentido utilitario, señalando su valor de uso; esta impronta se sostiene en los componentes materiales presentes en la construcción que permiten resaltar los detalles de diseño y construcción de sus canales y terrazas principalmente. Este relevamiento inicial da lugar a un estudio de su distribución espacial, que a su vez sustenta la explicación acerca de su funcionamiento hidráulico, lo cual orienta la lectura y enmarca los tópicos geográficos y sociales, que a continuación contribuirán a estructurar un relato cuidadosamente documentado. Cabe subrayar que el texto se acompaña con un prolijo registro fotográfico que facilita la lectura y comprensión de una redacción que, si bien evita ser ilegible, emplea un vocabulario técnico. Al respecto es necesario indicar también, que la presente edición es una traducción de su original en inglés.
City Branding Dimensions, Strategies, and Obstacles: A Literature Review
Authors: Zahrah Fatimatuz
Published: June 2023

City branding is carried out to develop cities, attract tourism, introduce the city's wealth, and improve the community's quality of life. Various ways are done to show the uniqueness and distinctiveness that is owned. Some city branding efforts are seasonal, in vain, fail, and must be clarified for the public. This study aims to analyze the dimensions of city branding, strategies to build city branding, and obstacles and solutions in building city branding. This research is a critical literature review reviewing 35 articles from 2017 to 2023 and focusing on the progress of research on city branding. The formulation and findings of this study are the dimensions of city branding, namely tourist attraction, security and public services, and public policy and government coordination with the community. The city branding strategy can be carried out in five ways: introducing cultural diversity, culinary diversity, natural wealth, improving public services and security, and promoting and building a mascot. The obstacles to city branding are the need for coordination between the government and the community, inadequate facilities and infrastructure, and unclear concepts related to the city branding used. The implications of this research indicate that city branding efforts must be integrated between government policies and community participation. Full involvement of the government and good cooperation with community members and Small and Medium Enterprise (creative community groups) is recommended to be one of the efforts to build city branding in various cities and is also recommended for city branding program plans.
A Systematic Literature Review on the Efficacy of Emerging Computer Technologies in Inclusive Education for Students with Autism Spectrum Disorder
Authors: Ahmad Lawan Abdulmalik , Ibrahim Yarima Kamaluddeen , Ibrahim Usman Hamisu , Isah Abba Sani , Usman Yakubu Haruna , Garba Musa Abdullahi
Published: June 2023

Including learners with autism spectrum disorder (ASD) in mainstream classrooms is associated with challenges that could impede their academic participation. However, studies have shown the value of inclusive education, especially when supported with computer technologies, learners with ASD can effectively learn alongside their non-autistic peers. Despite that, there has been minimal research on ASD inclusion with emerging computer technologies. This paper presents a systematic review of the literature on the application of emerging computer technologies in supporting the inclusion of learners with ASD. By analyzing a wide range of scholarly articles, this research goes beyond the existing literature by thoroughly examining the unique contributions and advancements made in this field. The study findings revealed valuable strategies and technologies for ASD-inclusive education that could be utilized by educationists, researchers, and relevant stakeholders. Moreover, this research bridges the knowledge gap and provides a foundation for future investigations into effective and sustainable technological interventions for ASD-inclusive education.
Heart Rate Variability and Pregnancy Complications: Systematic Review (Preprint)
Authors: Sharifi-Heris Zahra , Rahmani Amir M , Axelin Anna , Rasouli Mahkameh , Bender Miriam
Published: June 2023

BACKGROUND

The autonomic nervous system (ANS) is known as a critical regulatory system for pregnancy-induced adaptations. If it fails to function, life-threatening pregnancy complications could occur. Hence, understanding and monitoring the underlying mechanism of action for these complications are necessary.

OBJECTIVE

We aimed to systematically review the literature concerned with the associations between heart rate variability (HRV), as an ANS biomarker, and pregnancy complications.

METHODS

We performed a comprehensive search in the PubMed, Medline Completion, CINAHL Completion, Web of Science Core Collection Classic, Cochrane Library, and SCOPUS databases in February 2022 with no time span limitation. We included studies concerned with the association between any pregnancy complications and HRV, with or without a control group. The PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guideline was used for the review of the studies, and Covidence software was used for the study selection process. For data synthesis, we used the guideline by Popay et al.

RESULTS

Finally, 12 studies with 6656 participants were included. Despite the methodological divergency that hindered a comprehensive comparison, our findings suggest that ANS is linked with some common pregnancy complications including fetal growth. However, existing studies do not support an association between ANS and gestational diabetes mellitus. Studies that linked pulmonary and central nervous system disorders with ANS function did not provide enough evidence to draw conclusions.

CONCLUSIONS

This review highlights the importance of understanding and monitoring the underlying mechanism of ANS in pregnancy-induced adaptations and the need for further research with robust methodology in this area.
Flattening Hierarchical Structures to Empower Women Trainee Leaders on Social Media Teams (Preprint)
Authors: Kays Marah N , Rupert Deborah D , Negris Olivia , Thompson Beatrix , Clayman Marla L , Mordell Lisa , Pendergrast Tricia , Bloomgarden Eve , Bhayani Rakhee K , Jain Shikha
Published: June 2023

UNSTRUCTURED

We share our experience empowering women trainees and leadership through a flattened hierarchical social media team structure with supporting evidence from measurable outcomes.