bluuebunny/crossref_metadata_2025 huggingface dataset:
Apprendre à discerner les différences : un difficile travail de reconnaissance
Authors: Greisch Jean
Published: July 2018

Le concept de différence nécessite que le philosophe examine au préalable sa boîte à outils conceptuelle pour faire l’inventaire de l’usage qui est fait de ce mot à l’intérieur de différents « jeux de langage », car il y a les différences visibles et celles d’un ordre invisible. Nous sommes conviés à une leçon d’apprentissage des différences, réflexion qui cherche à les différencier pour mieux les connaître afin que, dans chaque domaine épistémologique, les débats contemporains se laissent instruire par ces différences propres.
Écrire l’histoire judéenne aux périodes perse et grecque : un défi identitaire
Authors: Abadie Philippe
Published: July 2018

Après avoir montré l’héritage de l’historiographie perse dans l’historiographie judéenne des IV-III e siècles av. J.-C., l’auteur met en lumière la manière dont les livres d’ Esdras-Néhémie d’un côté, et des Chroniques de l’autre, ont cherché à définir l’identité judéenne par le biais d’une écriture historiographique. Au final se dessinent deux appréhensions fort différentes de cette réalité, alors même que ces livres usent abondamment de schémas scripturaires empruntés aux livres de la Torah et des Prophètes, à travers continuité et rupture.
L’arrivée des penseurs orthodoxes en Europe occidentale à la suite de la révolution d’Octobre
Authors: Arjakovsky Antoine
Published: July 2018

Cet article fait le récit de quelques débats qui agitèrent l’intelligentsia russe au cours de la Première Guerre mondiale puis présente l’un des principaux fruits du renouveau de la pensée chrétienne orthodoxe post-moderne, à savoir la redécouverte de l’icône et l’invention de l’art concret. Vladimir Ern et Nicolas Berdiaev, Vassily Kandinsky, et Serge Boulgakov, des intellectuels passés par le marxisme et le nietzschéisme avant de retrouver la foi chrétienne, furent les principaux protagonistes de cette prise de conscience de la fin de la Modernité et de l’avènement d’un « nouveau Moyen-Âge ». Leur influence sur la pensée occidentale fut considérable.
Repenser la Providence
Authors: Euvé François
Published: July 2018

La notion classique de providence divine (conduite du monde par un Dieu bienveillant) soulève plusieurs objections : la présence du mal, la liberté de l’homme, la conception d’un agir divin. À la différence de la perspective stoïcienne qui mettait l’accent sur l’ordre du monde, la tradition chrétienne valorise une liberté qui ouvre une histoire. La poursuite de cette histoire fait appel à une pluralité d’instances.
Du petit théâtre au grand, et retour
Authors: Karsz Saül
Published: July 2018

Articuler le maintien à domicile et le placement en institution spécialisée est fort instructif, à la condition de ne pas loger tous les mérites d’un côté et tous les inconvénients en face. Car le placement à domicile mobilise, lui aussi, des agréments formels et des prestations sociales : il s’agit d’une institution à part entière. Des aidants informels y exercent des savoir-faire, pas exempts toutefois de défaillances et dérapages, les institutionnels n’en ayant pas le monopole. C’est en termes de partenariat, de collaboration, d’irrigation réciproque que la question du maintien à domicile et du placement spécialisé gagne à être posée en théorie et opérée en pratique.
Три-ткани Бола $B_m^{\triangledown}$ с тензором кручения ранга $\rho$
Authors: Onoprienko Ekaterina Andreevna , Shelekhov Aleksandr Mikhailovich
Published: July 2018

Рассматриваются инфинитезимальные свойства многомерных средних три-тканей Бола с ковариантно постоянным тензором кривизны (ткани $B_m^{\triangledown}$); заложены основы классификации таких тканей по рангу тензора кручения. Для три-ткани $B_m^{\triangledown}$ ранга $\rho$ методом Картана построен адаптированный репер и найдена соответствующая система структурных (дифференциальных) уравнений. Доказывается, что три-ткань $B_m^{\triangledown}$ ранга $\rho$ несет нормальную подткань, которая является групповой, причем соответствующая факторткань является регулярной три-тканью. Путем интегрирования структурных уравнений найдены новые семейства примеров многомерных три-тканей специального типа и гладких луп Бола, являющихся обобщением полупрямого произведения двух абелевых групп Ли.
Библиография: 40 названий.
Спектр усреднения функции над псевдотраекториями динамической системы
Authors: Osipenko Georgy Sergeevich
Published: July 2018

Рассматриваются дискретная динамическая система, порожденная гомеоморфизмом $f$ на компактном многообразии $M$, и непрерывная функция $\varphi$. Усреднение функции $\varphi$ над периодической $\varepsilon$-траекторией - это среднее арифметическое значений $\varphi$ на периоде. Предельное множество усреднений над периодическими $\varepsilon$-траекториями при $\varepsilon \to 0$ называется спектром усреднения. Показано, что спектр состоит из отрезков, каждый отрезок порожден компонентой цепно-рекуррентного множества и может быть получен как усреднение функции $\varphi$ по всем инвариантным мерам, сосредоточенным на данной компоненте.
Библиография: 18 названий.
The Irish Dramatic Revival 1899–1939
Authors: Roche Anthony
Published: July 2018

This is a fresh reassessment of the work of the principal playwrights associated with the Irish Dramatic Revival, a movement that was to radically redefine Irish theatre and see the birth of the world’s first national theatre, the Abbey, in 1904. The work of O’Casey and Synge has had a profound influence on generations of writers and remains key to the study of modern drama, whereas work by Yeats and Lady Gregory has received renewed attention among theatre makers and scholars owing to their radical innovation and range.

From a consideration of the twin strands of Irish drama prior to the revival, Anthony Roche considers the work of Synge and his experimentation in the creation of a new national drama that drew on native sources while developing a modern and prophetic form of theatre. He explores the role of Yeats as founder and playwright; the role of women and in particular Lady Gregory as producer and dramatist; and the playwrights who emerged following independence. O’Casey’s ground-breaking Dublin plays receive detailed consideration, and the new Irish modernism that followed in the 30s and which also witnessed the founding of the Gate Theatre in Dublin.

The Companion also features a number of essays from other leading scholars and contemporary practitioners offering a variety of critical perspectives on this period of radical change and development in modern Irish theatre.
Aerosol–cloud interactions in mixed-phase convective clouds – Part 2: Meteorological ensemble
Authors: Miltenberger Annette K. , Field Paul R. , Hill Adrian A. , Shipway Ben J. , Wilkinson Jonathan M.
Published: July 2018

Abstract. The relative contribution of variations in
meteorological and aerosol initial and boundary conditions to the variability
in modelled cloud properties is investigated with a high-resolution ensemble
(30 members). In the investigated case, moderately deep convection develops
along sea-breeze convergence zones over the southwestern peninsula of the UK.
A detailed analysis of the mechanism of aerosol–cloud interactions in this
case has been presented in the first part of this study
(Miltenberger et al., 2018). The meteorological ensemble (10 members) varies by about a factor of 2 in
boundary-layer moisture convergence, surface precipitation, and cloud
fraction, while aerosol number concentrations are varied by a factor of
100 between the three considered aerosol scenarios. If ensemble members
are paired according to the meteorological initial and boundary conditions,
aerosol-induced changes are consistent across the ensemble. Aerosol-induced
changes in CDNC (cloud droplet number concentration), cloud fraction, cell number and size, outgoing shortwave
radiation (OSR), instantaneous and mean precipitation rates, and precipitation
efficiency (PE) are statistically significant at the 5 % level, but
changes in cloud top height or condensate gain are not. In contrast, if
ensemble members are not paired according to meteorological conditions,
aerosol-induced changes are statistically significant only for CDNC, cell
number and size, outgoing shortwave radiation, and precipitation efficiency.
The significance of aerosol-induced changes depends on the aerosol scenarios
compared, i.e. an increase or decrease relative to the standard scenario. A simple statistical analysis of
the results suggests that a large number of realisations (typically >100)
of meteorological conditions within the uncertainty of a single day are
required for retrieving robust aerosol signals in most cloud properties. Only
for CDNC and shortwave radiation small samples are sufficient. While the results are strictly only valid for the investigated
case, the presented evidence combined with previous studies highlights the
necessity for careful consideration of intrinsic predictability,
meteorological conditions, and co-variability between aerosol and
meteorological conditions in observational or modelling studies on aerosol
indirect effects.
Comparison of air quality at different altitudes from multi-platform measurements in Beijing
Authors: Ji Hongzhu , Chen Siying , Zhang Yinchao , Chen He , Guo Pan , Zhao Peitao
Published: July 2018

Abstract. The features of upper-air visibility at altitudes of 0.1, 0.3, and 0.5 km and
the two-dimensional haze characteristics in the northwest of downtown Beijing
were studied by using a multi-platform analysis during haze episodes between
17 December 2016 and 6 January 2017. Through the multi-platform data
analysis in hourly and daily variation, the upper-air visibility increased
along with the decrease of PM2.5 mass concentration. And the upper-air
visibility on non-haze days was about 3–5 times higher than that on haze
days with the ground-based Raman–Mie lidar data between 13 December 2016 and
11 January 2017. The vertical transport of pollutants can be inferred from
the delayed variation of upper-air visibility between high altitude and low
altitude. In addition, the two-dimensional haze characteristics could be
studied by analyzing the correlation between vertical haze parameters
(atmospheric boundary layer, haze thickness, and aerosol optical thickness)
and horizontal haze parameter (upper-air visibility). The characteristics of
multi-parameters have been analyzed and concluded for different haze levels.
A novel semi-direct method to measure OH reactivity by chemical ionization mass spectrometry (CIMS)
Authors: Muller Jennifer B. A. , Elste Thomas , Plass-Dülmer Christian , Stange Georg , Holla Robert , Claude Anja , Englert Jennifer , Gilge Stefan , Kubistin Dagmar
Published: July 2018

Abstract. An operational chemical ionization mass spectrometer (CIMS) for hydroxyl
radical (OH) and sulfuric acid (H2SO4) concentration
measurements was adapted to include observations of OH reactivity,
which is the inverse of OH lifetime, for long-term monitoring at the
Global Atmosphere Watch (GAW) site Hohenpeissenberg (MOHp), Germany.
OH measurement using CIMS is achieved by reacting OH with
SO2, leading to the production of H2SO4, which is then
detected. The adaptation for OH reactivity consists of the
implementation of a second SO2 injection, at a fixed point further
down flow in the sample tube to detect the OH decay caused by
reactions with OH reactants present in the sample. The method can measure OH reactivity from less than 1 to 40 s−1
with the upper limit due to the fixed positioning of the second SO2
injection. To determine OH reactivity from OH concentration
measurements, the reaction time between the two titration zones and OH
wall losses in the sample tube need to be determined accurately through
OH reactivity calibration. Potential measurement artefacts as a result
of HOx recycling in the presence of NO have to be considered.
Therefore, NO contamination from gases used in instrument operation must be
minimized and ambient NO must be measured concurrently to determine the
measurement error. This CIMS system is shown here to perform very well for OH reactivity
below 15 s−1 and NO concentrations below 4 ppb, both values that are
rarely exceeded at the MOHp site. Thus when deployed in suitable chemical
environments, this method can provide valuable continuous long-term
measurements of OH reactivity. The characterization utilizes results
from chamber, laboratory and modelling studies and includes the discussion
and quantification of sources of uncertainties.
The SPARC water vapour assessment II: comparison of stratospheric and lower mesospheric water vapour time series observed from satellites
Authors: Khosrawi Farahnaz , Lossow Stefan , Stiller Gabriele P. , Rosenlof Karen H. , Urban Joachim , Burrows John P. , Damadeo Robert P. , Eriksson Patrick , García-Comas Maya , Gille John C. , Kasai Yasuko , Kiefer Michael , Nedoluha Gerald E. , Noël Stefan , Raspollini Piera , Read William G. , Rozanov Alexei , Sioris Christopher E. , Walker Kaley A. , Weigel Katja
Published: July 2018

Abstract. Time series of stratospheric and lower mesospheric water vapour
using 33 data sets from 15 different satellite instruments were compared in
the framework of the second SPARC (Stratosphere-troposphere Processes And
their Role in Climate) water vapour assessment (WAVAS-II). This comparison
aimed to provide a comprehensive overview of the typical uncertainties in the
observational database that can be considered in the future in observational
and modelling studies, e.g addressing stratospheric water vapour trends. The
time series comparisons are presented for the three latitude bands, the
Antarctic (80∘–70∘ S), the tropics
(15∘ S–15∘ N) and the Northern Hemisphere mid-latitudes
(50∘–60∘ N) at four different altitudes (0.1, 3, 10 and
80 hPa) covering the stratosphere and lower mesosphere. The combined
temporal coverage of observations from the 15 satellite instruments allowed
the consideration of the time period 1986–2014. In addition to the
qualitative comparison of the time series, the agreement of the data sets is
assessed quantitatively in the form of the spread (i.e. the difference
between the maximum and minimum volume mixing ratios among the data sets),
the (Pearson) correlation coefficient and the drift (i.e. linear changes of
the difference between time series over time). Generally, good agreement
between the time series was found in the middle stratosphere while larger
differences were found in the lower mesosphere and near the tropopause.
Concerning the latitude bands, the largest differences were found in the
Antarctic while the best agreement was found for the tropics. From our
assessment we find that most data sets can be considered in future
observational and modelling studies, e.g. addressing stratospheric and lower
mesospheric water vapour variability and trends, if data set specific
characteristics (e.g. drift) and restrictions (e.g. temporal and spatial
coverage) are taken into account.
Tracing winter temperatures over the last two millennia using a north-east Atlantic coastal record
Authors: Polovodova Asteman Irina , Filipsson Helena L. , Nordberg Kjell
Published: July 2018

Abstract. We present 2500 years of reconstructed bottom water temperatures (BWT) using
a fjord sediment archive from the north-east Atlantic region. The BWT
represent winter conditions due to the fjord hydrography and the associated
timing and frequency of bottom water renewals. The study is based on a ca.
8 m long sediment core from Gullmar Fjord (Sweden), which was dated by
210Pb and AMS 14C and analysed for stable oxygen isotopes
(δ18O) measured on shallow infaunal benthic foraminiferal species
Cassidulina laevigata d'Orbigny 1826. The BWT, calculated using the
palaeotemperature equation from McCorkle et al. (1997), range between 2.7 and
7.8 ∘C and are within the annual temperature variability that has
been instrumentally recorded in the deep fjord basin since the 1890s. The
record demonstrates a warming during the Roman Warm Period (∼350 BCE–450 CE), variable BWT during the Dark Ages (∼450–850 CE),
positive BWT anomalies during the Viking Age/Medieval Climate Anomaly (∼850–1350 CE) and a long-term cooling with distinct multidecadal
variability during the Little Ice Age (∼1350–1850 CE). The fjord BWT
record also picks up the contemporary warming of the 20th century (presented
here until 1996), which does not stand out in the 2500-year perspective and
is of the same magnitude as the Roman Warm Period and the Medieval Climate
Anomaly.
Quantifying the impacts of human water use and climate variations
on recent drying of Lake Urmia basin: the value of different sets of
spaceborne and in-situ data for calibrating a hydrological model
Authors: Hosseini-Moghari Seyed-Mohammad , Araghinejad Shahab , Tourian Mohammad J. , Ebrahimi Kumars , Döll Petra
Published: July 2018

Abstract. During the last decades, the endorheic Lake Urmia basin in northwestern Iran has suffered from decreased precipitation, groundwater levels and a very strong reduction in the volume and more recently also in the extent of Lake Urmia. Human water use has exacerbated the desiccating impact of climatic variations. This study quantifies the contribution of human water use to the reduction of inflow into Lake Urmia, to the loss of lake water volume and to the loss of groundwater and total water storage in the entire Lake Urmia basin during 2003–2013. To this end, the WaterGAP Global Hydrology Model (WGHM) was manually calibrated specifically for the basin against multiple in-situ and spaceborne data, and the best-performing calibration variant was run with or without taking into account water use. Observation data encompass remote-sensing based time series of annual irrigated area in the basin from MODIS, monthly total water storage anomaly (TWSA) from GRACE satellites and monthly lake volume. In-situ observations include time series of annual inflow into the lake and basin averages of groundwater level variations based on 284 wells. In addition, local estimates of sectoral water withdrawals in 2009 and return flow fractions were utilized. Four calibration variants were set up in which the number of considered observation types was increased in a stepwise fashion. The best fit to each and all observations is achieved if the maximum amount of observations is used for calibration. Calibration against GRACE TWSA improves simulated inflow into Lake Urmia but still overestimates it by 90 %; it results in an overestimation of lake volume loss, underestimation of groundwater loss and a shifted seasonality of groundwater storage. Lake and groundwater dynamics can only be simulated well if calibration against groundwater levels leads to adjusting the fractions of human water use from groundwater and surface water. According to our study, human water use was the reason for 50 % of the total basin water loss of about 10 km3 during 2003–2013, for 40 % of the Lake Urmia water loss of about 8 km3 and for up to 90 % of the groundwater loss. Lake inflow was 40 % less than it would have been without human water use. We found that even without human water use, Lake Urmia would not have recovered from the significant loss of lake water volume caused by the drought year 2008. These findings may serve to support water management in the basin and more specifically Lake Urmia restoration plans.
The Evidence of the Fiscal Incentive to Increase the HDI: The Case of Maranhão
Authors: Lima Fernando Silva , Yoshitake Mariano
Published: July 2018

This article is the result of an investigation about tax incentives in the State of Maranhão, where the purpose was to answer the question: what is the efficiency of tax incentives in relation to the impact on the state of employment? The hypothesis behind this research is that the idea of the Maranese government to create fiscal incentives to stimulate the generation of employment and income can not impact the regions with low human development index (HDI). The general objective of this article is to verify the relationship between the fiscal incentive and the balance of jobs between 2010 and 2016 in Maranhão in regions with lower HDI. The specific objectives are: to investigate the policy of granting the fiscal incentive "more companies" in Maranhão; compare the number of jobs generated with the number of companies that benefited from the tax incentive; to verify the evolution of the jobs generated in each mesoregion and to know the economic activities that generate more jobs in the state. This study is justified because it believes in the relevance it can bring to the academic environment and to the society that encompasses government, companies and professionals, since it presents a more comprehensive perspective regarding economic development in the local regional government of Maranhão. It considers the methodology of this study, a field research, but of quantitative-descriptive character. Among the results, it was identified that the fiscal incentive had no impact on job creation in the Meso-regions that have the lowest HDI indices in the state of Maranhão between 2010 and 2016.
Teaching Life Writing Texts in Europe, Part II
Authors: Kersten Dennis , Mreijen Anne-Marie , Delhey Yvonne
Published: July 2018

Introduction to Teaching Life Writing, Part II
Twitter, Investor Sentiment and Capital Markets: What Do We Know?
Authors: Ali Heba
Published: July 2018

Nowadays, the social media play a central role not only in “de-asymmetrizing” the information between firms and investors but also in influencing the emotional response to this information. The social media have provided firms with the opportunity to construct their image and stimulate significant attention and positive emotional responses (i.e. celebrity firm). Investors also become no longer passive participants; they can now communicate, re-tweet, comment, mention, react to information and express their sentiment/views. Theoretically, this should exert a positive impact on information diffusion and so the market efficiency. However, as the social media also significantly influence the public mood and emotional response to any new information/news, several behavioral explanations contradicting with the concept of market efficiency (e.g. investor sentiment and herding behavior) become more reasonable. The study aims at providing a literature review and synthesis of research on the impact of social media sentiment in the context of capital markets, scrutinizing the theoretical understanding of this impact, underlining the methodological challenges related to extracting the sentiment, and reviewing the main empirical findings on the impact in the context of Twitter and StockTwits, which will enable researchers to evaluate and classify existing studies, obtain useful insight into the theoretical understanding of the impact of social media sentiment, hence spurring further theoretical and empirical research.
Financial Literacy of African American College Students: Evidence and Implications from One Historically Black Institution
Authors: Singh Kusum
Published: July 2018

This study examines the level and determinants of financial literacy among African American college students of a historically black college. The results from this study show that financial literacy is very low among African-American college students: less than 4% of respondents could answer all five financial literacy questions designed to test basic economics and financial concepts used in everyday lives. While determining factors that influence financial literacy of African American college students, the study finds that being in higher-class ranks and older in age have significant effects on students’ financial literacy levels. The findings of this study support the need for financial literacy education for African American college students of a historically black college to effectively promote their financial literacy levels.
Evaluation the Relationship Between Serum and Salivary Levels of 25(OH)Vit.D with Type II Diabetes in Newly Diagnosed Diabetics
Authors: Abdolsamadi Hamidreza , Vahedi Mohammad , Borzouei Shiva , Soltanian Alireza , Hosseini Ali , Avval Meghdad Zakavati
Published: July 2018

Introduction: The International Diabetes Federation (IDF) Announces 415 million people around the world are suffering from diabetes. There is a high proportion of UDM (undiagnosed diabetes) at the level of the world and particularly in developing countries. The number of people with UDM in Iran in 2015 are 2197.96 per 1000. Vitamin D3 deficiency is associated with increased risk of type 2 diabetes and for a long time, been recognized as a risk factor for glucose intolerance. Salivary composition, as the mirror of oral health, its use as a diagnostic tool is increasing and diabetes is also can be effective on the flow rate of saliva and its compounds. Analysis of saliva can be used as part of the evaluation of endocrine function. Material and Methods: In this case-control study in 2016 in Hamadan, we selected 57 newly diagnosed patients with type 2 diabetes mellitus with mean aged 47.73 years and 57 healthy controls with mean aged 45.36 years. By using Spitting method, 5ml of completely unstimulated saliva samples were collected from diabetic patients and control subjects. The serum and saliva 25(OH)Vit.Dconcentrations were measured by ELISA. The results are analyzed by SPSS 16.Results: Significant difference was found in serum concentrations between the two groups (p<0.001). But in unstimulated whole salivary 1, 25(OH) 2D3 concentrations between the two groups, difference was not significant and the relationship, was reversed. There was a significant correlation (P=0.013) between serum and saliva 1, 25(OH) 2D3concentrations in the control group. In other words, the correlation was approximately 0.33. Correlation between serum and saliva 1, 25(OH) 2D3 concentrations in case group was not significant. Serum levels of 1, 25(OH) 2D3 in 21.1% of control group, showed the inadequate level (Vit.D3= 20-29ng/ml) and in the case group, showed the critical situation and overall 91.2% of the newly diagnosed diabetics, suffered from lack of vitamin D3. According to the salivary levels of 1, 25(OH) 2D3, in general, a total of 58% of the case group, have deficiency of vitamin D3.Conclusion: The results was confirmed vitamin D3 deficiency in participating in the study population (both case and control). The findings showed that there is lower concentration of 1, 25(OH) 2D3 in serum and after that in saliva in diabetic patients that newly diagnosed. Saliva would play a helpful diagnostic role in the early detection, the monitoring and progression of diabetes, but still serum is the better method for detecting vit.D3 levels and more research needs to be done on saliva for detecting Vit.D3 concentrations.
Strength and functional analysis of mechanical locking system created by additive manufacturing SLS
Authors: Grygoruk Roman , BAJKOWSKI Marcin , Wzorek Arkadiusz
Published: July 2018

The paper presents a preliminary strength analysis of an additional mechanical connector that improves the durability of a furniture joint locking system. Limited functional verification of a prototype was made by using 3D printing technology SLS. The construction of the additional connector was based on modules which increase diameter during the assembly of a widely used furniture connection. An additional force is obtained to prevent the loss of joint durability under changing climatic conditions of furniture usage. The essence of the presented research is also the indication of the SLS technology as a possible way of manufacturing the final product in the form of a multibody system in a pre-assembled configuration.
Nodular Regenerative Hyperplasia Induced by Trastuzumab Emtansine: Role of Emtansine?
Authors: Lepelley Marion , Allouchery Marion , Long Jérôme , Boucherle Dorothée , Ranchoup Yves , Le Marc’Hadour François , Villier Céline , Sturm Nathalie
Published: July 2018

Trastuzumab is a monoclonal antibody targeted against the Human Epidermal Growth Factor Receptor 2 (HER2) overexpressed in some breast cancer. This targeted therapy significantly improves the prognosis of these cancers. Recently an anti-HER2 antibodydrug conjugate was shaped in order to facilitate the targeted delivery of potent cytotoxic drug to cancer cells and to reduce resistance. This formulation, called trastuzumab emtansine (T-DM1), consists of the monoclonal antibody trastuzumab linked to a cytotoxic drug (a derivative of maytansine) via a chemical linker. Little is known about adverse reactions due to this new formulation. Herein we described the case of a woman suffering from a HER2-positive breast cancer, treated with trastuzumab for 30 months followed by T-DM1 monotherapy. After 12 months of T-DM1 treatment, a nodular regenerative hyperplasia confirmed by liver biopsy occurred. T-DM1 was stopped and medical imagery showed a resolution of the nodular regenerative hyperplasia. Unfortunately, hepatic metastasis progressed. Few cases of nodular regenerative hyperplasia induced by T-DM1 have been described so far. Further studies are needed to explore pathogenesis of nodular regenerative hyperplasia with this new antibody-drug conjugate treatment.
Salidroside and Curcumin Formula Prevents Liver Injury in Nonalcoholic Fatty Liver Disease in Rats
Authors: Li Hong-Shan , Ying Hao , He Zhe-Yun
Published: July 2018

Introduction and aim. Salidroside and curcumin (SC) formula could alleviate lipid deposition in high fat diet-induced nonalcoholic fatty liver disease (NAFLD). However, the mechanisms are still unknown, and the magnitude of potential therapeutic benefit remains understudied. Material and methods. The rats were treated with high fat diet for 14 weeks to induce NAFLD. The experiment was divided into control, model (NAFLD), SC formula and rosiglitazone groups (n = 7 in each group). Hematoxylin-eosin (H&E) staining was applied to detect liver morphological changes. Biochemical, metabolic indices and inflammation factors in liver tissue and serum were detected. Additionally, the activities of related enzymes were detected by enzyme-linked immunosorbent assay. Results. In the established rat model, typical lipid deposition and liver steatosis were observed. Liver triglyceride, free fatty acids, sera alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase, fasting insulin, fasting blood glucose and homeostasis model assessment of insulin resistance were elevated in model group. Liver malondialdehyde was significantly elevated, while superoxide dismutase was significantly decreased in model group, compared with control. Moreover, tumor necrosis factor-α
and Interleukin-1 were significantly produced in model group, compared with control. As a mechanism, high fat diet decreased tissue
AMP-activated protein kinase (AMPK), phosphorylated AMPK, carnitine palmitoyltransferase 1 and increased inacetyl-CoA carboxylase (ACCase), phosphorylated ACCase. Importantly, these abnormal changes caused by high fat diet were reduced by SC formula administration. Conclusion. SC formula could ameliorate the injury caused by high fat diet. The effect was likely mediated via its influence on insulin resistance, lipid peroxidation injury and AMPK signaling pathway.
Rescue Therapy for Genotype-3 DAA Non-responders, Almost all Done
Authors: Llerena Susana , Cabezas Joaquín , Cuadrado Antonio , Olmos José Manuel , González Marta , García Federico , Cobo Carmen , Crespo Javier
Published: July 2018

Nowadays, the retreatment of patients with Hepatitis C virus (HCV) genotype 3 (GT3) especially cirrhotic, who have already been treated with regimens containing a NS5A inhibitor represents a challenge. Use a novel retreatment option for patients with a difficult approach. We present three case reports of retreatment with a new combination of Direct-acting antivirals (DAAs), Sofosbuvir, Elbasvir/ Grazoprevir in patients with GT3 with a previous failure with Sofosbuvir/Ledipasvir. All the cases achieved sustained virologic response (SVR) at week +12 without adverse effects. In our experience, this combo may represent an effective and safe option for these patients.
The Effect of ICOS Polymorphism Interactions with HBV Mutations on HBV Subtype Infection Outcomes
Authors: Song Xiao-Mei , Li Qing-Ling , Guo Feng , Peng Hong , Guo Jin-Jun
Published: July 2018

Introduction and aim. Hepatitis B virus (HBV) infection remains a public health problem worldwide. In addition, HBV infection results are influenced by various virological, immunological, and genetic factors. Inducible T-cell costimulator (ICOS) polymorphisms involving chronic HBV infection have been confirmed in previous studies. This study was to explore the effects of ICOS single nucleotide polymorphisms in HBV subtypes and their interactions with viral mutations on HBV infection outcomes. Material and methods. A total of 1,636 Han Chinese individuals were recruited, including 47 asymptomatic HBV carriers (ASC), 353 chronic hepatitis B (CHB) patients, 327 HBV-related liver cirrhosis (LC) patients, 193 HBV-related hepatocellular carcinoma (HCC) patients, 464 patients with spontaneous recovery from HBV infection (SR), and 252 healthy controls (HC). DNA samples from these subjects were genotyped for four ICOS SNPs (rs11883722, rs10932029, rs1559931, and rs4675379). Direct sequencing was used to determine the HBV mutations in the enhancer II, basal core promoter, and pre-core regions. Results. We found that the genotype “TC” of ICOS rs10932029 SNP was associated with decreased HBV-related LC risk in the genotype C group. Additionally, the A1762T, G1764A and A1762T/G1764A mutations were associated with an increased risk of LC in the genotype C group. Further study indicated that interactions between ICOS rs10932029 genotype “TC” and A1762T or A1762T/G1764A mutations significantly decreased
the LC risk in the genotype C group. Conclusion. The rs10932029 genotype “TC” might be an LC-protective factor for HBV genotype C infection. The interactions between the rs10932029 genotype “TC” and A1762T or A1762T/G1764A mutations could decrease
the risk of LC.
HLA Class II-DRB1 Alleles with Hepatitis C Virus Infection Outcome in Egypt: A Multicentre Family-based Study
Authors: El-Bendary Mahmoud , Neamatallah Mustafa , Elalfy Hatem , Besheer Tarek , Kamel Emily , Mousa Hend , Eladl Abdel-Hamid , El-Setouhy Maged , El-Gilany Abdel-Hady , El-Waseef Ahmed , Esmat Gamal
Published: July 2018

Introduction and aim. Hepatitis C virus (HCV) infection is a global medical problem. HLA –DRB1 alleles have an important role in immune response against HCV. The aim of this study is to clarify the contribution of HLA –DRB1 alleles in HCV susceptibility in a multicentre family-based study. Material and methods. A total of 162 Egyptian families were recruited in this study with a total of 951 individuals (255 with chronic hepatitis C (CHC), 588 persons in the control group(-ve household contact to HCV) and 108 persons who spontaneously cleared the virus (SVC). All subjects were genotyped for HLA -DRB1 alleles by SSP-PCR and sequence based typing (SBT) methods. Results. The carriage of alleles 3:01:01 and 13:01:01 were highly significant in CHC when compared
to that of control and SVC groups [OR of 3 family = 5.1289, PC (Bonferroni correction ) = 0.0002 and 5.9847, PC = 0.0001 and OR of 13 family = 4.6860, PC = 0.0002 and OR = 6.5987, PC = 0.0001 respectively]. While DRB1*040501, DRB1*040101, DRB1*7:01:01 and DRB1*110101 alleles were more frequent in SVC group than CHC patients (OR = 0.4052, PC = 0.03, OR: OR = 0.0916, PC = 0.0006, OR = 0.1833, PC = 0.0006 and OR = 0.4061, PC = 0.0001 respectively). Conclusions. It was concluded that among the Egyptian families, HLA- DRB1*030101, and DRB1*130101 alleles associated with the risk of progression to CHC infection, while DRB1*040101, DRB1*040501, DRB1*7:01:01and DRB1*110101 act as protective alleles against HCV infection.
Improvement in Waldenström’s Macroglobulinemia after Successful Treatment of HCV with Direct-acting Antivirals
Authors: Crespi Mattia , Demarzo Maria Giulia , Brunacci Matteo , Pellegatta Gaia , Ferrando Fabio , Ballestrero Alberto , Grillo Federica , Savarino Vincenzo , Giannini Edoardo G.
Published: July 2018

Chronic hepatitis C (HCV) virus infection may be associated with several non-hepatic manifestations, mainly driven by chronic immune stimulation, such as mixed cryoglobulinemia and Non-Hodgkin’s Lymphoma. This association has been proved by several meta-analyses and some interventional studies demonstrating that antiviral treatment may be effective in inducing HCV-associated lymphoma regression. The recent advent of direct acting antivirals (DAAs) in the therapeutic armamentarium of HCV infection made possible treatment of patients with advanced liver disease. Here we report on a rare association of a cirrhotic patient with HCV and Waldenström’s Macroglobulinemia with severe cryoglobulinemia, who had already failed an interferon-based antiviral regimen, whose haematologic disease was ameliorated by HCV eradication following treatment with sofosbuvir and simeprevir with ribavirin, and where successful treatment was accompanied also by consistent improvement in liver function and parameters of portal hypertension.
Descrição temporal do comportamento do Cerrado sensu strictu usando séries temporais
Authors: Machado Sérgio Luís Dias , Silva Claudionor Ribeiro , Araújo Aracy Alves de
Published: July 2018

Currently has been a growing concern about the relationship between humans and nature. The challenges to making this relationship more sustainable have been pointed out. Together with this growing need and concern environmental, geotechnologies appear as strong allies, especially in the generation of more accurate and updated data to assist in tasks such as environmental management and planning in the processes of exploration of a given biome. In this context, this study aimed to analyze the phenological behavior of Cerrado phytophysiognomies (Pirapitinga Ecological Station - MG) with the use of time series of NDVI and surface temperature determined from digital images, obtained with the Landsat 5-TM sensor. For this, a study was carried out with the two time series, analyzing the intrinsic variables, such as trend, seasonality, prediction and cointegration. The prediction of the NDVI series presented a standard error lower than 0.079, which represents a quality information about the phytophysiognomy analyzed at a future time. This is a very important fact, given that currently the Cerrado suffers from an accelerated process of degradation. Therefore, it is useful information in processes of recovery, maneuver and management of degraded areas.
Obstacles to municipal environmental licensing - Analysis of the main difficulties and obstacles in the environmental licensing procedures of municipalities
Authors: Mendez Gabriel De Pinna , Cardoso Júnior Ricardo Abranches Felix
Published: July 2018

Environmental licensing is one of the main instruments of the National Environmental Policy, mainly due to its nature of prevention of the significance of environmental damages. After the enactment of complementary law no. 140/11, municipalities were given the explicit competence to license enterprises and activities whose environmental impact is classified as local, provided they have a qualified technical body and a municipal environmental council. After almost six years of enforcement of the aforementioned complementary law, it is verified that most municipalities have not yet been able to implement an efficient and effective environmental licensing system, configuring themselves as mere emitters of environmental licenses. The main problems encountered in municipal environmental licensing are addressed in this paper, such as inconsistencies in the definition of competence of the licensing body, deficiencies in the normative framework, mainly regarding legislation on land use and occupation (zoning), low technical capacity and Lack of independence of municipal environmental agencies, excessive bureaucracy and high processing time, as well as lack of transparency and social control. The analysis of these obstacles points to the need for improvements and effective changes in municipal environmental systems, making environmental licensing play the role of collective protection.
Avaliação da chuva prevista em curto prazo por radar meteorológico
Authors: Bacelar Luiz Carlos Salgueiro Donato
Published: July 2018

This article presents the first evaluation of the method used by the Brazilian Centre for Monitoring and Early Warning of NaturalDisasters for the short term forecast (nowcasting) of precipitation by weather radar. In this evaluation, four cases of intenserainfall in the radius of Pico do Couto radar were studied, giving the flood risk alerts sent for the municipality of Nova Friburgo,in the state of Rio de Janeiro. In relation to rain gauge data, a median under rate of 43% for the radar precipitation wasobserved when using the SRI (Surface Rainfall Intensity) method. After the rainfall correction, the cross-correlation extrapolationmethod was evaluated for the 30, 60, 90 and 120 minute forecast horizons, with accumulated precipitation every 30 minutes. Theprobabilities of detection (POD) obtained higher values for lower rainfall thresholds (at least 1 or 5 mm of accumulated rainfall)when compared to larger amount accumulated (20 and 30 mm). The spatial and temporal series of rainfall presented higher errors(MAE and RMSE) for 90 and 120 minutes of forecast. For all the events, an overestimate (PBIAS positive) of the predictions wasobserved in relation to the observed radar rain field itself.
Analysis of the technological impact on industry and its effects on waste production and disposal: a case study of the surfboard manufacturing industry
Authors: Barcelos Ricardo Luis , Magnago Rachel Faverzani , Leripio Alexandre Avila
Published: July 2018

Cleaner Production (CP) advocates the application of preventive and integrated  strategies to processes products minimizing the generation of waste and pollution. However, not always technological innovations in production bring with it an improvement for CP. The surfboard industry has been dismissive of CP. Studies revealed a concentration of the production residues on the manufacturers due to the vertical process of the production stages. Nonetheless, the incorporation of machining technology of the polyurethane blocks through Computerized Numerical Control (CNC) led to a horizontal process. The aim of this study was to map the current process, identifying the major waste producers, and detailing management for these wastes. A case study was carried out to examine the surfboard  industry. The survey revealed that the links of the production chain can be accomplished by the diverse actors participating in the manufacturing industry. However, the largest amount of waste is produced by big manufacturing industries rather than small, outsourced companies. It became clear that the introduction of CNC technology was responsible for the centralization of waste production, previously distributed among all manufacturers. Technological innovation had no impact on the reduction or reuse of waste or even a better management of its disposal.
Développer des compétences pour favoriser la connaissance du passé dans les programmes d’études: le cas de l’enseignement de l’histoire dans l’enseignement secondaire au Québec
Authors: Éthier Marc-Andre , Cardin Jean-FranÇois , LefranÇois David
Published: July 2018

Se revisan las críticas al enfoque de las habilidades
históricas y se sintetizan investigaciones
empíricas recientes sobre los
efectos de este enfoque en el aprendizaje
del pensamiento histórico. A este respecto,
se propone una comparación de la efectividad
de este enfoque en comparación
con el de la enseñanza centrada en la narrativa
ya construida del maestro.
Identidades reflexivas en la universidad: sonidos, imágenes y microrrelatos autobiográficos
Authors: Ayala Herrera Isabel María , Sánchez López Virginia
Published: July 2018

La presente investigación tiene como objetivo
la búsqueda de nuevas formas de
generar e integrar identidades en el aula
usando el potencial pedagógico y creativo
del microrrelato audiovisionado. Teniendo
en cuenta que el currículum oficial y
generalista suele silenciar las voces individuales
de los estudiantes, para amplificarlas
defendemos el uso del método
autoetnográfico y la experimentación
con los lenguajes narrativo y audiovisual,
favoreciendo la interdiscursividad. Estas
premisas conceptuales guiaron un proyecto
de investigación-acción diseñado como
actividad introductoria en una asignatura
de música universitaria. Los estudiantes,
de diferentes procedencias, intereses y
perfiles, participaron en la creación y narración
de un microrrelato autobiográfico
con dos soportes extraliterarios, música e
imagen, en el que indagaron en su imaginario
sonoro. El estudio concluye que estas
nuevas aproximaciones desde el foco
sociocrítico e interpretativo, en combinación con la metodología cualitativa, son
altamente eficaces a fin de dar respuestas
comprometidas que potencian la inteligencia
y las capacidades de los estudiantes,
favoreciendo la construcción de su
identidad y satisfaciendo sus intereses de
una manera creativa e integral.
La interpretación dialógica como práctica estratégica. Análisis de la toma de decisiones de cinco intérpretes en los Servicios Públicos
Authors: Arumí Ribas Marta
Published: July 2018

Este artículo analiza el comportamiento estratégico del intérprete-mediador chino-español en los servicios públicos del ámbito socioeducativo ante problemas de diversa índole (léxicos, culturales, pragmáticos, derivados de la gestión de la conversación y cuestiones éticas y profesionales). Los datos del estudio se obtuvieron a partir de quince simulaciones filmadas que recreaban situaciones habituales en la interpretación en el ámbito socioeducativo y fueron complementados por cinco cuestionarios pre-tarea y cinco entrevistas post-tarea dirigidos a cada uno de los participantes en el experimento.

El análisis descriptivo permite establecer una primera categorización de algunos recursos estratégicos que emplean los intérpretes. Frente a una destacada aparición de estrategias de mediación activa y una menor presencia de las técnicas propias de la interpretación, la autora aboga por la importancia de trazar la diferencia entre mediación intercultural e interpretación en contextos como el estudiado para asegurar la transparencia y la autonomía de las partes. Asimismo, destaca la relevancia que tiene formar a los futuros intérpretes de manera consciente sobre la importancia de tomar decisiones estratégicas a la hora de resolver los problemas.
The Impact of the Source Language in Spanish Translations: A Survey on English Counterfactuals ‘Should have’
Authors: Repiso Isabel
Published: July 2018

The present article shows that the most frequent way of translating Should have + Past participle in Spanish is the word-by-word translation Debería haber. This preference is not coherent with the language use of natives at three levels: (i) the marginal role of modal verbs to express the speaker’s subjectivity in Spanish; (ii) the preferred use of modal verbs in the past participle position (e.g., No hubiese debido tener libros); and (iii) the predominant use of the pluperfect subjunctive as a prompting tense for counterfactual readings. Our survey is based on 1.7  million-word Social Sciences corpus covering 8 essays, 4 political biographies and 2 dystopian novels. In all, 9  sentences containing should have + past participle were analyzed. The translations were crossed with a reference corpus in Spanish containing 154 million words (CREA). The translators’ preference by Debería haber has an effect in the output texts’ readability since it implies a reversal in the frequencies of the Spanish constructions pertaining to the irrealis semantic domain. Our results provide empirical cues to prevent the word-by-word translation Debería haber, such as avoiding infinitive periphrastic constructions or favoring subjunctive mood’s tenses.