bluuebunny/crossref_metadata_2025 huggingface dataset:
EFFECTIVENESS OF ENDOVASCULAR TREATMENT OF IN-STENT RESTENOSIS AFTER SUCCESSFUL CHRONIC TOTAL CORONARY OCCLUSION RECANALIZATION
Authors: Stelmashok V. I. , Polonetskiy O. L. , Zotova O. V. , Strygo N. P. , Zatsepin A. O. , Zakharevich A. N. , Barysevich A. A. , Koush A. V. , Lazareva I. V.
Published: June 2019

Aim. To assess the effectiveness of endovascular treatment of in-stent restenosis after successful chronic total coronary occlusion (CTO) recanalization.

Methods. 117 patients who underwent successful CTO recanalization in the period from 2009 to 2012 were included in the study. All patients were referred to the elective examination including coronary angiography, intravascular ultrasound and optical coherence tomography within 6.1±0.9 months after the successful recanalization. If in-stent restenosis after CTO recanalization was confirmed and further endovascular treatment was performed, patients underwent repeat endovascular examination after 6.6±0.8 months. Сoronary artery lumen was evaluated at the sites of the performed intervention.

Results. 18.8% of patients had in-stent restenosis, of them 95.5% underwent percutaneous coronary intervention. 76.2% of patients underwent high-pressure balloon predilatation, 4.8% of patients received paclitaxel-eluting balloons, 14.2% of patients – drug-eluting stents (DES), and 4.8% of patients - bare-metal stents. A significant increase of minimum lumen diameter after the percutaneous coronary intervention (from 0.8±0.5 mm to 2.2±0.3 mm, p<0.01) and a decrease of coronary artery lumen stenosis (from 67.9±18.3% to 19.7±8.8%, p<0.01) had been determined. There were no cases of death, acute myocardial infarction, acute strokes and target lesion thrombosis 6.6±0.8 months after the in-stent restenosis treatment. 52.8% of cases had repeat restenosis, including 56.3% of those who underwent high-pressure balloon predilatation and 33.3% of patients after DES implantation. The minimum lumen diameter decreased from 2.2±0.3 mm to 1.6±0.5 mm (p<0.01), and the degree of lumen stenosis increased from 19.7±8.8 mm2 to 41.5±17.3 mm2 (p<0.01).

Conclusion. In-stent restenosis treatment after the successful CTO recanalization by the endovascular methods was effective in 47.2% of cases. DES and drug coated balloons can potentially reduce the rate of repeat restenosis.
IN-HOSPITAL RESULTS OF MINIMALLY INVASIVE OFF-PUMP CORONARY ARTERY BYPASS GRAFTING
Authors: Shabaev I. F. , Tarasov R. S. , Kozyrin K. A.
Published: June 2019

Aim. To evaluate the in-hospital results of minimally invasive direct coronary artery bypass grafting (MIDCAB) of the left anterior descending artery (LAD) on the beating heart.

Methods. 146 patients with stable coronary artery disease and hemodynamically significant LAD lesions were included in a single-center prospective study. The study endpoints included death, myocardial infarction (MI), stroke, bleedings associated with the CABG, repeated non-elective myocardial revascularization during the in-hospital period. The completeness of the performed revascularization was assessed by estimating the residual SYNTAX score. Additionally, the volume of perioperative blood loss and patients’ ICU and in-hospital length of stay were recorded. Wound complications, heart rhythm and conduction disturbances, respiratory complications were assessed.

Results. The mean patient age was 60±8.9 (36–82) years. The mean EuroScore II was 1.61±1.66%. The SYNTAX score was 11.7±9.5 (5–25.5) scores. After MIDCAB, the residual SYNTAX was 1.8±2.1 (0–12.5). The majority of patients had single-vessel disease (n = 108; 73.9%). More than half of the patients had postinfarction cardiosclerosis (PICS). 17.8% of patients had diabetes mellitus. 19% of patients were present with class 1–2 obesity. The mean left ventricular ejection fraction (LVEF) in the total sample was 61.3±7.5% (37–74%). Eight patients (5.5%) required the conversion of lateral minitracotomy to sternotomy followed by the LAD grafting on the beating heart. The mean volume of intraoperative blood loss was 293.4±117.9 mL. Reasonable incomplete myocardial revascularization was achieved in 24.7% of cases. There were no cases of in-hospital deaths in the study cohort. The incidence of MI, stroke and repeated non-elective myocardial revascularization was within the acceptable range of 0.7%, 0% and 2.7%, respectively. 6.1% of patients (n = 9) had wound complications (deep incisional surgical site infection). The mean length of stay in the intensive care unit was 1±0.2 days. The absolute majority of patients (n = 108) were discharged from the Department of Cardiac Surgery in the period of 10±1.2 days.

Conclusion. Off-pump MIDCAB demonstrated good results, low rate of cardiovascular complications and low volume of perioperative blood loss, lack of deep wound infection and shorter hospital length of stay.
MORTALITY FROM CIRCULATORY SYSTEM DISEASES IN THE KEMEROVO REGION AND THE RUSSIAN FEDERATION IN 2000–2016
Authors: Makarov S. A. , Maksimov S. A. , Shapovalova E. B. , Stryapchev D. S. , Artamonova G. V.
Published: June 2019

Aim. To estimate the trends in mortality from circulatory system diseases, including coronary artery disease and cerebrovascular diseases, in the Kemerovo region in the period from 2000 to 2016 and compare it with the national trends.Methods. Data on national mortality rates, including those among adults of working age (men 16–59 years, women 16–54 years) from circulatory system diseases, coronary artery disease and cerebrovascular diseases in the period from 2000 to 2016 were obtained through the national statistical reports. A linear trend in the regional mortality rate to the national one has been reported.Results. Mortality rate from circulatory system diseases in the period from 2000 to 2016 tends to a decrease in the Kemerovo region and the Russian Federation. The comparative analysis of mortality rates in the Kemerovo region and the Russian Federation reported lower regional mortality rates in the general population. Despite lower mortality rates from coronary artery disease in the general population and working population, there are higher mortality rates from cerebrovascular diseases. Conclusion. The trend in mortality from circulatory system diseases in the Kemerovo region is comparable to that in the Russian Federation. Specific regional features related to the interaction of various factors, including regional healthcare system, have been determined. The trends in mortality from coronary artery disease and cerebrovascular diseases in the period from 2000 to 2016 have been presented.
ABCG2 GENE POLYMORPHISM IN PATIENTS WITH GOUT IN ZABAIKALSKY KRAI
Authors: Kushnarenko N. N. , Mishko M. Yu. , Medvedeva T. A. , Vitkovsky Yu. A.
Published: June 2019

Aim. To study the frequency distribution of alleles and genotypes of the C421A locus (rs2231142, Q141K) of the ABCG2 gene in patients with gout and to evaluate their association with the risk of the disease development.

Methods. 80 patients (69 men and 11 women) with gout (mean age 54.8±12.4 years) were examined. Gout was diagnosed according to the ACR/EULAR classification criteria, 2015. The material for the study was DNA isolated from leukocytes of the whole peripheral blood. All patients were genotyped to detect polymorphism of the C421A locus (rs2231142, Q141K) of the ABCG2 gene. Statistical data processing was performed using Statistica 10.0 statistical software package.

Results. The results of the study of the C421A polymorphism (rs2231142, Q141K) of the ABCG2 gene demonstrated a high frequency of mutant A (χ2 = 5.58, p = 0.018, OR = 3.5, CI95% = 1.16–10.52) genotypes C/A (χ2 = 5.03, p = 0.024, OR = 3.5, CI95% = 1.11–10.98) among patients with gout compared with the control group. This fact indicates the significance of the ABCG2 gene rs2231142 locus in the development of gout and allows us to consider the carriage of the minor (A) allele and the C/A genotype as a molecular genetic factor in the development of the disease. The carriage of the wild-type allele (C) and the C/C genotype has a protective character, reducing the risk of developing the disease by 3.5 times.

Conclusion. ABCG2 C421A (rs2231142, Q141K) is associated with a high risk of developing gout among population of Zabaikalsky Krai. ABCG2 gene polymorphism can be considered as a genetic predictor of a higher risk of developing gout.
OPPORTUNITIES AND FUTURE PERSPECTIVES FOR REMOTE MONITORING OF PATIENTS WITH IMPLANTED DEVICES
Authors: Lomidze N. N. , Vaskovskiy V. A. , Yashkov M. V. , Artukhina E. A. , Revishvili A. Sh.
Published: June 2019

Today implantable cardiac devices (ICD) are advanced therapeutic and preventive tools ensuring the collection and transmission of statistical and diagnostic patient data. The information obtained from implanted devices allows analyzing patients’ condition, selecting optimal treatment strategy, predicting and preventing possible complications. The number of ICD recipients is rapidly growing. Over 1,000 devices per 1 million population are implanted in Europe and the US annually. In the Russian Federation this number reaches 300 devices per 1 million population. Routine medical checkups of patients with ICD should be performed 2–4 times a year, with an average length of about 20 minutes. It means that only in the Russian Federation physicians will have to work 20–40 thousand extra hours with a tendency towards its increase as this figure will grow simultaneously with growing patients’ number. Remote monitoring (RM) technologies may solve this problem. In 2000 Biotronik AG developed the world's first system for remote monitoring of anti-arrhythmic devices called the “Home Monitoring” system. It is based on the mobile RM of patients who received ICD. The information collected by the devices is transmitted to a special service center via mobile communication networks and after processing, the information is transferred to a physician’s website along with a text message and a fax. The information is instantly delivered from a patient to a physician. A closed information network "patient-service center-physician" was developed for the hospitals and their patients, providing a novel advanced monitoring and timely treatment of the patient.
Difficulties in differential diagnosis of symptomatic hypertensions
Authors: Khovaeva Ya. B. , Zinkovskaya T. M. , Moiseenko N. P. , Voronova E. I. , Batalova A. A. , Ivanova N. V. , Perepelitsyna O. N.
Published: June 2019

The paper presents a case of pregnant woman with polycystic ovary syndrome, which occurred after hemorrhagic stroke and detected dissecting aneurysm of the ascending aorta at the sinus level. Removal of non-viable fetus was performed, coronaroangiography, resection of aneurysm of ascending aorta and replacement of valve-containing conduit was successfully implemented.
Characteristic features of pregravid preparation of married couples with burdened reproductive anamnesis, taking into account the results of in-depth study of genital microbiocenosis
Authors: Sandakova E. A. , Savelyeva N. V. , Rakitina Yu. V. , Karpunina T. I. , Gosteva E. О.
Published: June 2019

Aim. To optimize the pregravid preparation of married couples on the basis of in-depth study of genital microflora and correction of genital microbiocenosis.

Materials and methods. One hundred twenty eight married couples were examined regarding their pregravid preparation. The study included clinical investigation, colposcopy, USI of small pelvis organs, bacterioscopic investigation of vaginal isolate and urethral smear (men), bacteriological investigation of cervical mucus and ejaculate, genetic typing of strains isolated. Uterine cervix biopsy and aspiration endometrial biopsy was performed according to indications.

Results.There was detected a strong positive correlation between bacteriospermia, chronic cervicitis and chronic endometritis (r > 0.6). It proves the role of bacteriospermia in development of the ascending infection of endocervix and endometrium. At the same time, opportunistic microflora in a married couple, revealed in the presence of bacteriospermia and chronic cervicitis, in 80 % of cases is identical that makes it possible to draw an analogy with sexually transmitted infections. In most cases, chronic cervicitis was shown to be a visible marker of chronic endometritis.

Conclusions. A thorough study of genital mucosa microbiocenosis, implemented in a married couple with burdened reproductive anamnesis at the stage of pregravid preparation, permits to raise its efficiency.
Sensitization rate and sum of sige-antibodies to apple grades of various colours. Association of these indices with severity of atopic dermatitis
Authors: Prilutsky A. S. , Tkachenko K. E. , Baranova O. V. , Sorokina O. V.
Published: June 2019

Aim. To assess the rate of sensitization to the grades of apples of various colours and analyze the association of the obtained indices and total sIgE levels of these grades with the severity of atopic dermatitis.

Materials and methods. The blood sera of 215 patients, suffering from alimentary allergy, were studied. The detection rate of sensitization and that of specific immunoglobulin E (sIgE) concentration sum to allergens of apple grades with various coating colours as well as the association of these indices with the degree of severity of atopic dermatitis (AD) was analyzed. Test-systems were used for immune-enzyme analysis of production. Statistical analysis of the obtained results was performed using the program “MedStat” (Donetsk).

Results. It was shown that the detection rate of sensitization to the grades with mixed red colour is reliably higher (p < 0.001) compared to the grades without coating colour. The degree of AD severity correlates with the total quantity of apple grades, to which sensitization has been revealed (p < 0.01), with the quantity of grades with mixed red colour, to which sensitization has been found (p < 0.01) and with sIgE sum to the grades with mixed red colour (p < 0.01). Reliable differences (p = 0.006) in the degree of severity of atopic dermatitis among persons, sensitized to apple grades and with no sensitization to this fruit were established.

Conclusions.The obtained data are to be used when choosing a diet and correcting it for persons with alimentary allergy and atopic dermatitis.
Short-and long-term results of distal pancreatectomy
Authors: Barykov V. N. , Istomin A. G. , Abdrashitov R. R. , Ryzhikh A. S.
Published: June 2019

Aim. To assess the results of distal pancreatectomy for malignant and benign tumors and chronic pancreatitis complications.

Materials and methods. Forty-seven patients, who underwent distal pancreatectomy, were under observation during the period from 01.01.2008 to 28.02.2019.

Results. The long-term results of surgical treatment demonstrated the following complications: pancreatic fistulas – 15 % of observations, pancreatogenic diabetes mellitus – 12.7 %, subphrenic abscesses – 10 %. In the long-term period after the surgery – from 10 years and not less than one year – 30 patients were followed up, constituting 63.8 % of the total number.

Conclusions. To prevent complications in the form of pancreatic fistula with pathological Wirsung duct dilatation more than 4–5 mm in diameter, it is necessary to form anastomosis between the pancreatic stump and the small bowel.
Physiological and neuropsychological features of adaptation to training in conditions of Western Ural among foreign students from India
Authors: Koryukina I. P. , Kulesh T. A. , Arbuzova T. P. , Zueva T. V. , Petrischeva A. V. , Shulkina S. G. , Cherkasova V. G. , Karakulova Yu. V. , Seksyaev N. E. , Chainikov P. N.
Published: June 2019

Aim. To study the physiological and neuropsychological features of adaptation to training in conditions of Western Ural among foreign students from India.

Materials and methods. The object of study – first-year foreign students from India and Russian students of E.A. Vagner Perm State Medical University (52 and 47 persons, respectively). There were studied the parameters of physical development and cardiovascular system, including those with loading, as well as hypoxia tolerance tests. The following indices were calculated: body mass index (BMI), Robinson and Kerdo index, cardiac performance index (CPI), strength index (SI). The health level was calculated by G.L. Apanasenko. Peculiar features of students’ neuropsychical status were studied using the following surveys: Spilberger-Hanin Anxiety Scale to determine personal and situational anxiety, Beck Depression Inventory (BDI), scale for assessment of depression symptoms CES-D, scale for assessment of quality of life SF-36 with subscales, Epworth Sleepiness Scale, asthenia scale MFI-20, CAM (cenesthesia, activity, mood).

Results. Among Indian students, dispersion of BMI values and lower dynamometry indices were established. Hypoxia tolerance in the groups was similar. Kerdo index values in the group of Indian students showed a tendency to vagotonia, in the control group – to normotonia. No significant differences in other indices were registered. Health level in the studied groups was in “dangerous” zone regarding the risk for development of chronic noninfectious diseases, especially in the group of Indian students. The situational anxiety level by Spilberg 1 scale, and depression level by CES-D scale were reliably higher in the group of foreign students (p < 0.0001). SF-36 PF and SF-36 GH scores in Indian students were reliably lower versus Russian. Psychical component of health by SF-36 MH subscale was significantly higher in Russian students.

Conclusions. Among first-year students from India, who study at Perm State Medical University, there is observed a complex adaptive syndrome, which needs to be taken into account and corrected to prevent deadaptation disorders and raise progress in studies as well as quality of life and health status.
Allergic morbidity in patients of different age groups
Authors: Minaeva N. V. , Devyatkova E. A.
Published: June 2019

Aim. To analyze the regularities of the prevalence of allergic diseases in patients of different age groups.

Materials and methods. Epidemiological indices of allergic diseases were studied in children, adolescents, adults and elderly persons using official statistical data.

Results. The general and primary morbidity, allergopathology structure and its dynamics were evaluated in patients of different age groups. The data, obtained in Perm Krai and the Russian Federation, were compared.

Conclusions. The level of atopic dermatitis (AD) is the highest in children, allergic rhinitis (AR) – in adolescents, bronchial asthma (BA) – in adolescents and elderly persons. The cases of BA prevail in the structure of allergopathology in all age groups, besides children. Among children AD cases make 50.5 % of all allergic diseases. In dynamics, AD has a tendency to reduction of general morbidity in all age groups, BA – in children; a tendency to elevation is typical for AR in children and adolescents, BA – in adolescents, adults and elderly persons.
Characterization of the oil from the abdomen part of smoked catfish (Pangasius hypophthalmus) processing by-product
Authors: Ayu Dewi Fortuna , Diharmi Andarini , Ali Akhyar
Published: June 2019

Smoke catfish (Pangasius hypophthalmus) processing place produces waste in the form of fish entrails. Abdominal fat is the main component of fish entrails and is a source of fish oil. This study was aimed to determine the physicochemical characteristics and composition the catfish abdominal fat. The oil was extracted by rendering the abdominal fat at 70°C for 5 h followed up by purification through bentonite and active charcoal. Crude catfish oil was observed to be semi-solid in texture, yellow and fishy. The purification improved the characteristics of the fish oil. The purified fish oil was white and less fishy. Furthermore, the purification step reduced the free fatty acid content, the acid number and peroxide value up to 11; 4 and 3 fold, respectively. Palmitic, stearic and myristic acid dominated saturated fatty acid group, representing 26.22; 5.06 and 2.85% of the total fat, respectively. Meanwhile, oleic and linoleic represented 40.14 and 19.97 of the total fat, respectively and were the dominant fatty acid of the unsaturated fatty acid group.
Crude Palm Oil Prediction Based on Backpropagation Neural Network Approach
Authors: Aini Hijratul , Haviluddin Haviluddin
Published: June 2019

Crude palm oil (CPO) production at PT. Perkebunan Nusantara (PTPN) XIII from January 2015 to January 2018 have been treated. This paper aims to predict CPO production using intelligent algorithms called Backpropagation Neural Network (BPNN). The accuracy of prediction algorithms have been measured by mean square error (MSE). The experiment showed that the best hidden layer architecture (HLA) is 5-10-11-12-13-1 with learning function (LF) of trainlm, activation function (AF) of logsig and purelin, and learning rate (LR) of 0.5. This architecture has a good accuracy with MSE of 0.0643. The results showed that this model can predict CPO production in 2019.
The Diffusion of ICT for Corruption Detection in Open Government Data
Authors: Darusalam Darusalam , Said Jamaliah , Omar Normah , Janssen Marijn , Sohag Kazi
Published: June 2019

Corruption occurs in many places within the government. To tackle the issue, open data can be used as one of the tools in creating more insight into the government. The premise of this paper is to support the notion that data opening can bring up new ways of fighting corruption. The current paper aimed at investigating how open data can be employed to detect corruption. This open data is trivial due to challenges like information asymmetry among stakeholders, data might only be opened partly, different sources of data need to be combined, and data might not be easy to use, might be biased or even manipulated. The study was conducted using a literature review approach. The reviews implied that corruption can be detected using Open Government Data, Thus, by conducting the open data technique within the government, the public could monitor the activities of the governments. The practical contribution of this paper is expected to assist the government in detecting corruption by using a data-driven approach. Furthermore, the scientific contribution will originate from the development of a framework reference architecture to uncover corruption cases.
Adam Optimization Algorithm for Wide and Deep Neural Network
Authors: Jais Imran Khan Mohd , Ismail Amelia Ritahani , Nisa Syed Qamrun
Published: June 2019

The objective of this research is to evaluate the effects of Adam when used together with a wide and deep neural network. The dataset used was a diagnostic breast cancer dataset taken from UCI Machine Learning. Then, the dataset was fed into a conventional neural network for a benchmark test. Afterwards, the dataset was fed into the wide and deep neural network with and without Adam. It was found that there were improvements in the result of the wide and deep network with Adam. In conclusion, Adam is able to improve the performance of a wide and deep neural network.
RÉDEAS PESSOA E LATERAL ATIVAM OS MESMOS MÚSCULOS SUPERFICIAIS EM EQUINOS
Authors: De Oliveira K. , Fachiolli D. F. , Da Silva D. A. , Bueno L. G. F. , De Moura D. J.
Published: June 2019

Objetivou-se identificar o padrão de ativação da musculatura superficial, por meio da termografia infravermelha, em cavalos atletas submetidos ao treinamento com rédea Pessoa ou lateral, monitorando-se as regiões cervical, torácica, dorsal, abdominal e pélvica. Foram utilizados dez equinos atletas da raça Quarto de Milha, delineados em parcelas subdivididas, resultando em dez repetições por tratamento. Utilizou-se dois tratamentos; no primeiro grupo os cavalos foram treinados a guia com o uso da rédea Pessoa e no segundo tratamento realizou-se o treino mediante uso da rédea Lateral. Imagens termográficas foram realizadas após dez minutos de trabalho a guia com as rédeas Pessoa e Lateral. As temperaturas médias da pele (Tp) foram analisadas para cinco regiões específica do corpo do cavalo, representando as regiões cervical, torácica, dorsal, abdominal e pélvica. Verificou-se ausência de efeito significativo (P>0,05) do uso das rédeas auxiliares Pessoa e Lateral sobre a ativação da musculatura superficial das regiões corporais cervical, torácica, dorsal, abdominal e pélvica, no qual os valores observados para Tp foram, respectivamente, de 33,23 e 33,62; 33,80 e 33,30; 32,83 e 32,42; 33,24 e 33,12; 33,43 e 33,30 °C. Concluiu-se que as rédeas auxiliares Pessoa e Lateral possuem o mesmo padrão de ativação da musculatura superficial em cavalos atletas.
CARACTERIZAÇÃO E DISTRIBUIÇÃO DA PRECIPITAÇÃO NO MUNICÍPIO DE LEÓPOLIS, PR
Authors: De Lima R. T.
Published: June 2019

O município de Leópolis, localizado no norte do estado do Paraná, possui estações pluviométricas em funcionamento desde o ano de 1976, no entanto nenhum estudo fora realizado para a caracterização e variabilidade das precipitações específico para o município, sendo esse tipo de informação indispensável para o planejamento agrícola e urbano. Nesse sentido, o objetivo do trabalho foi caracterizar e avaliar a variabilidade anual, mensal bem como quantificar o número de dias chuvosos e secos, além de definir diferentes níveis de probabilidade de precipitação. Foram utilizados dados pluviométricos disponibilizados pelo Instituto das Águas do Paraná, do período de janeiro de 1976 a dezembro de 2017, totalizando um histórico ininterrupto de 42 anos. A precipitação em Leópolis caracteriza-se com os maiores índices pluviométricos no período de setembro a maio e os menores de junho a agosto. Nos anos de 2015 e 1988 ocorreram a maior e menor precipitação anual respectivamente. A precipitação média anual do período foi de 1380,10 mm. Com a utilização da função gama incompleta foi possível expressar adequadamente a probabilidade de precipitação em Leópolis, estando as médias mensais de precipitação entre 40 a 50 % de probabilidade para os meses de maior precipitação e entre 25 a 40 % para os meses de menor precipitação. Os resultados podem auxiliar no planejamento de atividades agrícolas e urbanas além do melhor uso eficiente da água para o município de Leópolis.
PROPAGAÇÃO IN VITRO DE JEQUITIBÁ-BRANCO (Cariniana estrellensis): UMA ALTERNATIVA PARA PROGRAMAS DE REFLORESTAMENTO
Authors: Albino B. É. S. , Canatto R. A. , Cordeiro A. T. , Fukushima C. H. , Pilon A. M.
Published: June 2019

O objetivo deste trabalho foi determinar um protocolo de micropropagação da espécie jequitibá-branco (Cariniana estrellensis). As sementes foram incubadas em meio Murashige e Skoog (MS). O delineamento utilizado foi o inteiramente casualizado. Os tratamentos de desinfestação consistiram de imersão das sementes em solução de hipoclorito de sódio (NaClO) por diferentes tempos (5, 10, 15 e 20 minutos). Para a multiplicação in vitro, ápices caulinares, obtidos de vitroplantas, foram inoculados em meio de cultura MS contendo diferentes concentrações (0; 0,5; 1,0; 2,0 mg L-1) de 6-benzilaminopurina (BAP) e cinetina (KIN). No enraizamento in vitro das brotações foram utilizadas diferentes concentrações de ácido indol-3-butírico (AIB) e ácido 1-naftaleno acético (ANA) (0; 0,5; 1 mg L-1). A incubação dos tubos foi realizada no claro em sala de crescimento. Observou-se que a desinfestação utilizando NaClO por um período de tempo de 5 minutos proporcionou melhor descontaminação e germinação das sementes. A utilização de 1 mg L-1 de BAP adicionada ao meio de cultivo foi eficaz para a formação de brotações na etapa de multiplicação in vitro. A adição de 0,5 mg L-1 da auxina AIB ao meio de cultivo proporcionou melhor formação de raízes nas brotações, que após 30 dias de aclimatização, tiveram uma taxa média de sobrevivência de 65%. Portanto é necessária a utilização de reguladores de crescimento para a multiplicação in vitro de C. estrellensis, sendo possível obter mudas micropropagadas da espécie nas condições do presente trabalho.
Rapid and efficient in vivo angiogenesis directed by electro-assisted bioprinting of alginate/collagen microspheres with human umbilical vein endothelial cell coating layer
Authors: Yao Rui , Yousef F. Alkhawtan Ahmed , Chen Ruoyu , Luan Jie , Xu Mingen
Published: June 2019

Rapid reconstruction of functional microvasculature is the urgent challenge of regenerative medicine and ischemia therapy development. The purpose of this study was to provide an alternative solution for obtaining functional blood vessel networks in vivo, through assessing whether hydrogel-based microspheres coated by human umbilical vein endothelial cells (HUVECs) can direct rapid and efficient in vivo angiogenesis without the addition of exogenous growth factors or other supporting cells. Uniform alginate microspheres with adjustable diameter were biofabricated by electro-assisted bioprinting technology. Collagen fibrils were evenly coated on the surface of alginate microspheres through simple self-assembly procedure, and collagen concentration is optimized to achieve the highest HUVECs adhesion and proliferation. Immunofluorescence staining and gene analysis confirmed the formation of the prevascularized tubular structure and significantly enhanced endothelial gene expression. HUVECs-coated hydrogel microspheres with different diameters were subcutaneously injected in immunedeficient mice, which demonstrated rapid blood vessel regeneration and functional anastomosis with host blood vessels within 1 week. Besides, microsphere diameter demonstrated influence on blood vessel density with statistical differences but showed no obvious influence on the area occupied by blood vessels. This study provided a powerful tool for rapid and minimalinvasion angiogenesis of bioprinting constructs and a potential method for vascularized tissue regeneration and ischemia treatment with clinically relevant dimensions.
DETERMINATION OF SOME DOMESTIC RADIATORS’ THERMAL CAPACITY NUMERICALLY
Authors: DALKİLİC Ahmet Selim
Published: June 2019

Free convection and radiation comprise the heat transfer mechanisms
through which a hydronic household radiator conveys heat from its surface to
air and surrounding surfaces. It should also be noted that their performance
could be enhanced by improving surface geometries as well as increasing
temperature levels. In the present study, heat transfer rates and convective
heat transfer coefficients occurring through the investigated radiators, were
numerically examined. To this end, radiators at two different dimensions having
two different geometric shapes were drawn and analyzed in the program Ansys 17.
The heat transfer rates obtained from the program were validated via radiator
producer catalogues. Furthermore, the influence of parameters, such as water
velocity in the radiators and thus mass flow rate, temperature difference
between water inlet and outlet and also between radiator surface and
surrounding air on convective heat transfer coefficient over radiator, were
scrutinized.
STATISTICAL ANALYSIS OF WIND SPEED DISTRIBUTION WITH SINOP-TURKEY APPLICATION
Authors: KAVAK AKPINAR Ebru
Published: June 2019

In this study, the wind energy
potential of the Sinop region was analyzed statistically by using the Turkish
State Meteorological Station’s hourly wind speed data between the years of
2005-2014. The two- parameter Weibull and one-parameter Rayleigh probability
distribution functions were used to determine the wind energy potential of the
region. The probability
distribution functions were derived from the cumulative function and used to
calculate the mean wind speed and the variance of the actual data. The best way
of representing the performance of the Weibull and Rayleigh distributions is to
use the statistical parameters such as the correlation coefficient (R2),
chi-square (χ2) and the root mean square error analysis (RMSE).  The results of the study showed that Sinop has a mean wind speed of 3.36
m/s with a maximum value of 4.28 m/s in February of 2011, and a minimum value
of 2.41 m/s in March of 2013, while the corresponding mean wind power density is approximately 33.31
W/m2 for the whole year. In general, it was determined the wind speed
is higher during some winter and spring months, notably February and March, and
is lower during the autumn months. The Weibull distribution function was found
to be more appropriate than the Rayleigh distribution function.
COST EFFECTIVE OPERATION OF HVAC SYSTEM UNDER THERMAL DISTURBANCE
Authors: YİLBAS Bekir Sami
Published: June 2019

Varying cooling load requirements in HVAC system become a major concern
to many consumers because of the additional cost of electricity. The cooling
load variation of HVAC system usually occurs when the domestic house door is
frequently kept open for prolonged durations, which is particularly important
in hot seasons. The present study, addresses a comparison of energy consumption
due to the thermal disturbance during domestic house door  keep opened for various duration when the
Variable Frequency Driver (VFD) and ON/OFF controllers are installed in HVAC
system. The experiments are carried out in two identical houses during six warm
days in a hot season where the outdoor temperatures have similar patterns
throughout the days. The energy response of HVAC system is analysed
incorporating the thermal and the electricity consumption data because of the
change of the indoor temperature during opening of the house main door. The
cost analysis is carried out and it is extended to include several repeats of
door opening durations. It is the first time demonstrated that the energy
consumption for HVAC system increases dramatically when the house main door is
kept opened for several times in a day. The energy consumption and additional
cost increase significantly for the case when the period of the main door
opening is extended. In this case, VFD A/C controller unit achieves more energy
savings than that of ON/OFF A/C controller unit.
Proposta de Ação Interdisciplinar para o Ensino de Trigonometria no Ensino Fundamental
Authors: Rizzon Bruna Moresco , Marchioro Fernanda , Giovannini Odilon
Published: June 2019

O presente artigo tem como objetivo propor uma Unidade de Ensino Potencialmente Significativa (UEPS) sobre trigonometria para o nono ano do ensino fundamental relacionando assuntos da atualidade com o cotidiano da sala de aula. Para a realização desta UEPS os alunos serão estimulados ao trabalho em equipe, ao levantamento de dados, a utilização de artefatos tecnológicos e a realização de atividades que envolvem o raciocínio lógico. As disciplinas envolvidas nesta proposta são matemática, biologia, geografia e língua portuguesa que, trabalharão de maneira interdisciplinar e a luz da teoria da aprendizagem significativa de Ausubel.  http://dx.doi.org/10.18226/23185279.v7iss3p1
Avaliação da Sazonalidade da Qualidade da Água do Açude da Macela em Itabaiana/SE
Authors: Barbosa Alan de Gois , Santos Kelly Marina Silva , Michelan Denise Conceição de Gois Santos
Published: June 2019

A Lei Federal 9.433 de 1997 tem como um de seus objetivos a garantia de água em quantidade e qualidade adequadas para os usos atuais e futuros. Para isso, devem ser atendidos requisitos mínimos de qualidade dispostos na legislação ambiental. Este trabalho busca avaliar a influência das estações seca e chuvosa na qualidade da água do Açude da Macela, em Itabaiana, Sergipe. Para isso, foi aplicado o Índice de Conformidade ao Enquadramento (ICE), diferenciando os períodos seco e chuvoso. O ICE foi calculado através dos parâmetros de pH, OD, DBO, Nitrogênio Amoniacal, Fósforo e Coliformes Termotolerantes em três pontos de monitoramento. De modo complementar, foram aplicados testes estatísticos não paramétricos para as estações seca e chuvosa. Os resultados mostram que o Açude da Macela não atende aos padrões de qualidade estabelecidos para as Classes 1, 2 e 3 de água doce, bem como tem sua qualidade piorada no período chuvoso.  http://dx.doi.org/10.18226/23185279.v7iss3p24
Avaliação dos níveis de dióxido de nitrogênio e ozônio na Universidade do Vale do Taquari (Univates) utilizando amostradores passivos de baixo custo
Authors: Jung Heinen Carolina , De Almeida Silva Maria Cristina
Published: June 2019

O crescimento urbano e industrial vem agravando a qualidade do ar, provocando danos ao meio ambiente e à saúde humana. Uma alternativa para o monitoramento dos poluentes atmosféricos é a utilização de amostradores passivos, construídos a partir de materiais de baixo custo. O presente estudo busca analisar, por meio da construção de amostradores passivos de baixo custo, os níveis de liberação de 2 poluentes atmosféricos – Dióxido de Nitrogênio (NO2) e Ozônio (O3). Os amostradores foram alocados em 8 diferentes pontos da Universidade do Vale do Taquari – Univates – Lajeado/RS, escolhidos considerando o fluxo de veículos e pessoas. As campanhas de amostragem foram realizadas de forma trimestral, abrangendo um período aproximado de 1 ano, com exposição variando de 7 a 8 dias. Os resultados da extração dos poluentes contidos nos amostradores foram obtidos através de espectrofotometria ultravioleta/visível, e seus respectivos valores calculados através da primeira Lei de Fick. As concentrações obtidas mostram que os índices de NO2 e O3 foram satisfatórios. A maior concentração de NO2 observada ocorreu durante a campanha de abril/17, com 13,5 µ/m³. Já o O3 apresentou valores superiores à 27 µ/m³, nas campanhas de novembro/16, julho e setembro/17. Além disso, realizou-se a espacialização dos dados de concentração obtidos durante o estudo, a fim de verificar a distribuição das mesmas pelo Campus. Esta espacialização apresentou melhores resultados com o método de interpolação Inverso da Distância ao Quadrado. Conforme o método utilizado, a maior área com concentração de NO2 é compreendida entre os pontos 1 e 4. Já as concentrações de O3 apresentaram maior variabilidade, sendo que as maiores concentrações obtidas ocorreram próximas ao ponto 5. Considerando os resultados obtidos, conclui-se que o método de amostragem passiva com materiais acessíveis é viável, podendo ser utilizado em diferentes locais.  http://dx.doi.org/10.18226/23185279.v7iss3p32
Desempenho das etapas de tratamento de água, da estação de tratamento de água Poxim
Authors: Michelan Denise Conceição Gois Santos , Batista Isabela Ferreira , Batista Daniela Ferreira , Santos Débora de Gois , Mendonça Luciana Coelho , Lima Daniel Moureira Fontes
Published: June 2019

A água para consumo humano deve atender aos padrões de potabilidade estabelecidos pela Portaria 2914 e Portaria de Consolidação nº 5 do Ministério da Saúde, assim cabe às Estações de Tratamento de Água (ETA) garantir que a mesma chegue ao destino final livre de contaminações. Para isso, a estação de tratamento convencional é composta por mistura rápida, floculação, decantação, filtração e saída da água clorada. Neste trabalho buscou-se avaliar o desempenho das etapas de tratamento na ETA Poxim, localizada em Sergipe, de forma a caracterizar a eficiência da qualidade da água quanto aos parâmetros cor aparente, turbidez e pH, com o intuito de verificar possíveis desvios de etapa no tratamento, de modo a proporcionar menor intervalo de tempo e consequentemente chegar na distribuição o mais rápido possível. Como resposta, verificou-se que, de modo geral, na unidade de mistura rápida e floculação, não ocorreu remoção de cor aparente e turbidez. A decantação e a filtração são as unidades do tratamento de água em que melhor ocorre a remoção desses parâmetros com eficiência significativa. Algumas amostras de água da saída do filtro não atenderam aos limites de parâmetros recomendados pela Portaria do Ministério da Saúde e os piores resultados coincidiram com o período chuvoso. Diante do exposto, não se sugere período viável em fase de tratamento da água que possa passar por desvios de etapa no tratamento de água.  http://dx.doi.org/10.18226/23185279.v7iss3p7
When a Female Pope Meets a Biconfessional Town: Protestantism, Catholicism, and Popular Polemics in the 1630s
Authors: Machielsen Jan
Published: June 2019

The early modern afterlife of Pope Joan has been remarkably little studied, perhaps because its contours have seemed familiar: Joan’s existence was embraced by Protestants for its challenge to the apostolic succession of the papacy and rejected by Catholics for the same reason. This role reversal, which cast Protestants as defenders of monastic chronicles and Catholics as their critics, offers ostensible proof for the mercenary use of history in confessional polemics. This article uses an overlooked 1635 defence of the popess, the longest ever written, as a case study to argue the opposite: debates over Pope Joan could be vehicles for popular confessional grievances and identities, and they can teach us much about the difficulties facing the Catholic and Reformed churches in the 1620s and 1630s. Written in Dutch by a German minister of the Church of England, this lengthy treatise possesses a significance well beyond the local conditions – a public disputation in a small biconfessional town in the Duchy of Cleves – that gave rise to its publication.
The Old Indies at the French Court: Johan Maurits’s Gift to Louis XIV
Authors: Anderson Carrie
Published: June 2019

In 1679 Prince Johan Maurits (1604-1679), the former governor-general of Dutch Brazil, presented French King Louis XIV (r. 1643-1715) with an extravagant gift comprised of Brazilian-themed images and objects, including a set of eight cartoons by the Dutch artist Albert Eckhout (1610-1665), which would be transformed into a set of tapestries known as the Old Indies (Anciennes Indes). This article will focus on the points of convergence between the Old Indies and the Escalier des Ambassadeurs, or Ambassador’s Staircase, at Versailles – the decoration of which was being completed at the same time Johan Maurits presented his gift. Aimed at making tangible the possibility of colonial conquest, the immersive environments created by the tapestries and the staircase’s convincingly painted spectacle blurred the boundaries between reality and representation, mediating an ideological space that existed between the static, centralized authority of the French court and the far-flung colonial possessions it sought to acquire.
Delimitation of the ‘Public’ and Freedom of Conscience: Catholics’ Survival Tactics in Legal Discourses in Utrecht, 1630-1659
Authors: Yasuhira Genji
Published: June 2019

This article aims to clarify Catholics’ survival tactics in discourses by analysing legal proceedings against them in the city of Utrecht from 1630 until 1659. This period saw a tendency towards Reformed confessionalisation, as is apparent from the rise in the number of such trials. However, despite the advent of anti-Catholic legislation under increasing pressure from the Reformed Church, Reformed confessionalisation was not completed, as the Catholic presence in the public sphere of Utrecht was never extinguished. Backed by their civic status, and with the aid of defenders in (supra-confessional) socio-judicial networks, accused Catholics developed a variety of discourses during legal proceedings. Obedient conformity to the existing norm of the public/private distinction was just one of the various discursive tactics for survival employed by Catholics in Utrecht. Despite the crucial discontinuity caused by the Protestant Reformation and the Dutch Revolt, Catholics continued to be actors in the constant and communal process of delimitation of the ‘public’. Members of the Catholic social elite in particular could actively create space for survival by discursively mobilising alternative interpretations of the ‘public’ and ‘conscience’ that retained medieval legacies, without conceptualising ‘privacy’ in the modern sense.
Hearing Global Modernity: The Case of the Travelling Oud
Authors: Willson Rachel Beckles
Published: June 2019

Musical instruments are integrated into the fabric of societies throughout the world and, like any number of objects, are adapted as they travel. In this article I place the oud (the eastern lute) in the context of a transformation that the late Arif Dirlik identified as ‘global modernity’, and analyze the career of the remarkable and hugely influential Iraqi musician Munir Bashir (1930–1997). I also use Bashir and his oud to nuance and extend aspects of the model set out by Dirlik which, for all its strengths, is geographically partial, and focuses strongly on the productive side of global competition and diversification. As I will demonstrate, Bashir’s oud was a part of the global modernity being negotiated by actors in the Iraqi, European and American culture-political spheres. But its success reveals the partiality of those negotiations, the precariousness of globally shared power, and the divisions between cultural, political and socio-economic spheres of ‘hearing’.
Motivations for textbook and learning resource publishing: Do academics want to publish OA textbooks?
Authors: Collins Ellen , Stone Graham
Published: June 2019

The affordability of textbooks and unsustainable commercial models are issues that many libraries face. As an alternative, there is a growing movement in the United States around open and affordable textbooks. However, to date there has been less activity in the UK despite the introduction of a range of policies that encourage or mandate open access publication of research outputs such as journal articles or monographs. These policy changes have affected academics’ attitudes to open access, but it is not yet clear whether the opportunity to publish in open access would affect researchers’ propensity to create non-research outputs such as textbooks and learning materials. In 2017, Jisc Collections proposed a study into author incentives for textbook publishing in order to understand whether open access would motivate authors to publish learning materials and thereby support a transition to open access for e-textbooks. The study consisted of a survey, focus groups and interviews. This article discusses the results of the research and provides several key insights and future opportunities for those wishing to explore open and affordable textbooks.
Metabolomics Based Study of the Antileishmanial Activity of Xanthium strumarium Leaf Extract on Promastigotes Phases of Leishmania major by Proton NMR Spectroscopy
Authors: AHMADI Mohammad , AKBARI Ziba , ALIKHANI Mahbobeh , HAJHOSSIANI Reza , ZAMANI Zahra , ARJMAND Mohammad
Published: June 2019

Background: Xanthium strumarium L. is extensively used as a traditional herb to treat many diseases and is also known as a source of phytochemicals. It has been used traditionally to treat trypanosomiasis, malaria fever, eczema, cancer, ulcer, fever, herpes headache, and skin lesion such as leishmaniasis. In this preliminary study, nuclear magnetic resonance (NMR)-metabolomics approaches was used to evaluate the inhibitory effects and metabolic alterations caused by leaf extract of X. strumarium on the stationary phases of promastigotes in Leishmania major.
Methods: The promastigotes were cultured in Biochemistry Laboratory at Pasteur Institute of Iran in 2017, stationary phases were obtained from 5 to 6 day-old cultures and treated with different concentrations of the plant’s extract. Antileishmanial activity was assayed by MTT method and cell metabolites were extracted. 1H NMR spectroscopy was applied, and outliers were separated using multivariate statistical analysis.
Results: The most affected metabolic pathways in the experimental groups were limited to amino sugar and nucleotide sugar metabolism, cyanoamino acid metabolism, starch and sucrose metabolism, butanoate metabolism, and galactose metabolism.
Conclusion: The ethanolic leaf extract of X. strumarium is a potent growth inhibitor of Leishmania major and can affect vital metabolic pathways of Leishmania promastigotes. The assay provided new perspectives on the development of novel treatment strategies for leishmanial activity derived from natural products.