bluuebunny/crossref_metadata_2025 huggingface dataset:
КОМПЛИМЕНТ КАК ФОРМУЛА РЕЧЕВОГО ЭТИКЕТА В АСПЕКТЕ МЕЖКУЛЬТУРНОЙ КОММУНИКАЦИИ В ЧЕЧЕНСКОМ ЯЗЫКЕ
Authors: Арсакаева Х.С.
Published: February 2022

Статья является продолжением цикла, посвященного этикетным формулам чеченского языка и выявлением их семантико- функциональных особенностей. Изучение речевых формул позволяет выявить определенные нормы, которые регулирует языковое поведение. Статья посвящена рассмотрению речевой этикетной формулы, как комплимент. Целью нашей научной статьи является изучение комплимента как неотъемлемой формулы речевого этикета в чеченском языке, и это обусловлено необходимостью изучения национально- культурных особенностей коммуникативного поведения. Под коммуникативным поведением понимают правила и традиции общения той или иной лингвокультурной общности. Интерес данной проблемы заключается и в том, что в чеченском языкознании речевые этикетные формулы в целом не были до сих пор объектом лингвистического исследования, но за последние годы уже появилось несколько работ в сравнительно-сопоставительном аспекте. В данной статье впервые предпринята попытка изучения речевых этикетных формул, а именно, комплимента на чеченском языке.
О СТИЛИСТИЧЕСКИХ ПРИЕМАХ В АНГЛИЙСКОМ ЯЗЫКЕ
Authors: Идразова Э.С.-А.
Published: February 2022

В данной работе нами предпринята попытка рассмотреть использование различных стилистических средств в английском языке. Стилистические приемы употребляются в различных жанрах для придания речи большей красочности и образности. Нами установлено, что выразительные приемы являются характерной чертой для всех художественных произведений. Однако они употребляются и в других жанрах. Нами рассмотрено употребление стилистических приемов в художественных произведениях, а также в загадках, сказках, пословицах и поговорках, песнях и ораторских речах, а также их использование в повседневной жизни. Широкое использование стилистических приемов в различных жанрах доказывает, что они имеют огромную значимость и их изучение является важным не только для лингвистов, но и для представителей других отраслей исследования.
БИЗНЕС-АНАЛИТИКА В УПРАВЛЕНИИ ФИНАНСОВЫМИ РИСКАМИ
Authors: Мержо М.Ш. , Янгульбаева Л.Ш.
Published: February 2022

В статье проведено исследование определения категории «риск» в трудах различных ученых. Рассмотрено управление финансовыми рисками на предприятии. Обобщены подходы к формированию современных стратегий и тактик управления рисками. Представлена последовательность этапов, которая наиболее полно отражает сущность процесса управления рисками. Охарактеризованы основные этапы управления финансовыми рисками и определено их функциональное значение. Установлено, что основными направлениями совершенствования системы менеджмента являются разработка и внедрение активного управления на основе системного и ситуационного подходов. Обосновано использование комплексных подходов и новых бизнес-концепций для эффективного управления финансовыми рисками. Рассмотрены и проанализированы основные элементы использования инструментария бизнес-аналитики. Бизнес-аналитика является универсальным инструментом управления рисками современного бизнеса.
ОСНОВНЫЕ ПОДХОДЫ И ПРИНЦИПЫ ФУНКЦИОНИРОВАНИЯ МЕЖДУНАРОДНЫХ ЛОГИСТИЧЕСКИХ СИСТЕМ
Authors: Бекмурзаев И.Д.
Published: February 2022

В статье исследована сущность понятия «логистическая система» и рассмотрены основные принципы ее функционирования, наиболее распространенные форматы функционирования и уровни международных логистических систем в настоящих условиях. Определены перспективные направления развития международной логистики. Выявлено, что логистическая система – это сложная организационно-структурированная экономическая система, состоящая из элементов (звеньев), взаимосвязанных в едином процессе управления ресурсными потоками. В настоящее время в мире функционируют логистические системы 5 уровней: First Party Logistics, Second Party Logistics, Third Party Logistics, Fourth Party Logistics и Fifth Party Logistics 5PL. Функционирование международных логистических систем осуществляется на основе общих принципов управления с учетом специфики логистической деятельности, в частности системность и комплексность, согласования критериев оценки эффективности, организации учета затрат и активного использования информационных технологий.
РАЗВИТИЕ ИНТЕРНЕТ-БИЗНЕСА КАК ЭЛЕМЕНТА КОММУНИКАЦИИ В ЛОГИСТИКЕ
Authors: Курбанов А.Х. , Бекмурзаев И.Д.
Published: February 2022

В статье рассмотрены перспективы развития Интернет-бизнеса в нашей стране и за рубежом. Проанализировано влияние цифровизации бизнес-процессов на коммуникационные процессы в логистике. Рассмотрены различные проблемы, связанные с реализацией возможностей Интернет-среды, и разнообразие направлений, по которым идет развитие и прогресс. Использование в работе Интернет-среды привело к появлению новых бизнес-моделей, которые имеют свои определенные особенности. Представлен перечень основных бизнес-моделей, которые охватывают различные виды коммерческой деятельности в Интернете. Количество онлайн-покупателей с каждым годом увеличивается, что свидетельствует о перспективах развития этого рынка. Цифровизация бизнес-процессов является практически единственным средством выживания отечественных предприятий в период карантинных ограничений.
ГЕОПОЛИТИЧЕСКИЕ АСПЕКТЫ ЛОКАЛЬНЫХ КОНФЛИКТОВ
Authors: Музаев М.З.
Published: February 2022

В статье сделан анализ локальных конфликтов, зависящих не только от их участников, но и государств, непосредственно оказывающих явную или скрытую поддержку одной из конфликтующих сторон, в угоду своих геополитических интересов. Проведена параллель в превращении военных конфликтов из разряда неконтролируемых процессов в инструменты прямого военно-политического воздействия на стратегического, потенциального союзника, для его удержания в орбите своих геополитических интересов в долгосрочной перспективе. Сделано сравнение геополитических процессов в период холодной войны с указанием основных причин противостояния в сравнении с современными причинами мировой геополитики.
СОЗДАНИЕ ПРЕОБРАЗОВАТЕЛЯ ДЛЯ ВЕКТОРИЗАЦИИ И НОРМАЛИЗАЦИИ ТЕКСТА НА ОСНОВЕ GENSIM И NLTK
Authors: Минаев О.М. , Вахажи Х.-М.М. , Успанова А.С.
Published: February 2022

Приложения обработки естественного языка существуют уже несколько десятилетий, добавление методов машинного обучения в эту сферу обеспечило определенную гибкость и скорость реагирования, которые при иных условиях были бы невозможны. Данная статья содержит описание алгоритма векторизации для объединения лингвистических приемов из пакета библиотек NLTK с приемами машинного обучения из Scikit­Learn и Gensim и создания собственных преобразователей для использования в повторяемых конвейерах многократного использования.
ПО МАТЕРИАЛАМ РЕПРЕССИЙ: ВОСПОМИНАНИЯ ДЕПОРТИРОВАННЫХ НАРОДОВ
Authors: Цуцулаева С.С.
Published: February 2022

В годы Великой Отечественной войны некоторые народы бывшего СССР были депортированы в восточные районы страны. Была ликвидирована государственность карачаевцев, калмыков, чеченцев, ингушей, балкарцев и крымских татар. На долгие тринадцать лет они оказались на чужбине. Произвол, учиненный над депортированными народами, будет еще долго привлекать к себе внимание ученых-исследователей и тех, кто лично пережил тринадцатилетнюю жестокую и унизительную ссылку, кто выстоял и выжил в невероятно трудной борьбе за жизнь, на которую государство обрекло каждого из них, превратив в одночасье в изгоев общества.
НЕКОТОРЫЕ ТРАДИЦИОННЫЕ ФОРМЫ ВЗАИМОПОМОЩИ У ЧЕЧЕНЦЕВ XIX – НАЧАЛА XX в
Authors: Бегуев С.А.
Published: February 2022

В статье рассматриваются некоторые традиционные формы взаимопомощи чеченцев XIXначала XX в., которые существовали с древних времен и получили особое развитие в рассматриваемое время. Большое внимание уделяется традиционным формам взаимопомощи, связанным с сельскохозяйственными и строительными работами чеченцев.
РОЛЬ ФИЛОСОФИИ В ЭПОХУ ЦИФРОВЫХ ТЕХНОЛОГИЙ
Authors: Денильханова Р.Х.
Published: February 2022

Современный мир переживает глобальную цифровую трансформацию. Практически не осталось ни одной из социальной, информационной, политической, экономической, культурной и биологической сфер без существенных изменений, связанных с цифровыми технологиями. Однако в поле философии также возникают все новые вопросы: какой вклад может внести философия в стремительно трансформирующуюся цифровую реальность? Как нам попытаться понять и продумать эти изменения? Как цифровые технологии бросают вызов прошлым идеям о том, кто мы и куда движемся? Где цифровизация подрывает наши этические устремления и заветные идеалы демократии, равенства, неприкосновенности частной жизни, доверия, свободы? С какими целями внедряются цифровые технологии, и как они влияют на сознание людей? В данной статье мы проанализировали, как общество воспринимает новые опосредования и «образ» нового цифрового мира. Также в статье исследован новый технологический ландшафт, который формируюет не только наши условия существования, но и идентификацию себя в мире.
ГНОСЕОЛОГИЧЕСКИЕ И ОНТОЛОГИЧЕСКИЕ ИСТОКИ СОЦИАЛЬНОЙ ИДЕНТИЧНОСТИ
Authors: Кутаев А.Х.
Published: February 2022

В данной статье исследуются онтологические и гносеологические признаки структуры принадлежности индивида к различным социальным группам. Исследуется и анализируется форма социальной идентичности личности в динамичной структуре и системе темпоральной протяженности. Отмечается, что понимание временных установок является новой условностью, благодаря которой индивид формулирует собственную значимость в общности. При этом определяется и вся будущая жизнедеятельность индивида, подчеркивая, что явление социальной принадлежности индивида в современных реалиях и мировой глобализации, должно быть наделено особым смыслом, и тем временем, сохранить свою актуальность в научных дискуссиях. Подчеркивается необходимость решения, выраженных социальных проблем общественной жизнедеятельности индивида, наиболее ярко проявляющихся в экономике, политике и правовой сфере. Обосновывается влияние темпоральности в социальной модернизации на представление индивида о собственной идентичности. Выявляя гносеологические и онтологические признаки социальной принадлежности индивида, делается вывод о необходимости разработок теорий для разрешения существующих в данной области проблем, а также выявления направлений будущего развития всего социума, к которому принадлежит индивид.
ОСНОВАНИЕ И УСЛОВИЯ НАСТУПЛЕНИЯ ЮРИДИЧЕСКОЙ ОТВЕТСТВЕННОСТИ: ХАРАКТЕРИСТИКА И СПЕЦИФИКА СООТНОШЕНИЯ
Authors: Идрисов Х.В.
Published: February 2022

В статье раскрываются основные элементы механизма юридической ответственности. Приводится правовая характеристика гражданского правонарушения как основания гражданско-правовой ответственности и таких условий ее реализации, как: противоправность, убытки, причинно-следственная связь между ними и вина. Указывается, что основание гражданско-правовой ответственности и условия ее реализации представляют из себя разноплановые элементы структуры механизма гражданско-правовой ответственности.
В заключении статьи приводится авторская формулировка субъективного условия гражданско-правовой ответственности – вины, под которой понимается волевое отношение лица, выраженное имущественными интересами, к противоправным действиям (бездействиям), которые причинили убытки другому, не заинтересованному в этом, лицу.
КАРТИНА КРОВИ СТУДЕНТОК В ПРОЦЕССЕ УЧЕБНОЙ ДЕЯТЕЛЬНОСТИ
Authors: Анзоров В.А.
Published: February 2022

В статье приведены результаты исследований по изучению состава крови студенток в процессе учебной деятельности. Приспособление девушек к учебному процессу вызывает достоверное увеличение уровня эритроцитов и гемоглобина, существенное сокращение времени свертывания крови и уменьшение количества тромбоцитов в крови. Количество эритроцитов, постепенно увеличиваясь, достигает максимального значения к последнему курсу – 4,3 млн. в мкл (P < 0,05), а в первом составило 3,9. Концентрация гемоглобина в крови девушек четвертого курса составляет 128,7 г/л (P < 0,02), а первого – 116,8. Содержание лейкоцитов в крови уменьшается в третьем курсе до 6,5 тыс. в мкл (P < 0,05), в четвертом до 6,1 (P < 0,02), относительно первого – 7,3. Скорость свертывания крови, постепенно сокращаясь к выпускному курсу, падает до 302 с (P < 0,02) по сравнению со значением первого курса – 344.
A REPRESENTAÇÃO MOTORA DA TÉCNICA DO CHUTE NO TAEKWONDO: PARÂMETROS PARA UM PROGRAMA DE TREINAMENTO MENTAL
Authors: Fonseca Alex Roger Cunha da , Cárdenas Ramón Núñez , Freire Ivete De Aquino , Macedo Marasella Del Cármen Silva Rodrigues , Macedo Fabio Jose De Queiroz , Souza Ednes Pereira Dos Santos , Pumariega Yesica Nunez , Torres Catalina Dominga Pumariega , Seixas Michele Freire , Silva Queila Rodrigues da , Silio Luís Felipe
Published: February 2022

O objetivo desta pesquisa foi avaliar a eficiência do chute Bandal Tchagui do Taekwondo dos atletas e a influência do treinamento mental. A fim de evidenciar que há uma influência direta do treinamento mental na melhoria do desempenho do chute, foi realizado um estudo de caso com 7 sujeitos, que posteriormente, haverá nova coleta, utilizando os mesmos procedimentos para identificar a evolução no que se refere à execução do movimento técnico. Para desenvolvimento da pesquisa, foram aplicados diferentes instrumentos: Os dados, nomeados aqui de pré-teste e pós-teste, serão coletados através da técnica de registro de imagem (filmagem), tanto da descrição verbal (Modelo interno) quanto da execução (Modelo externo) do movimento técnico. Os resultados preliminares mostraram que há uma disparidade entre os participantes tendo em vista suas especificidades no tempo de prática do esporte e no nível de habilidade, comparadas entre si.
DESEMPENHO ESPORTIVO DO ESTADO DE RONDÔNIA: MAPEAMENTO DOS ÚLTIMOS 5 ANOS
Authors: Freitas Raitanha Borges de , Cárdenas Ramón Núñez , Freire Ivete de Aquino , Araújo Edivaldo Botelho , Seixas Michele Freire , Santos Elisiane das chagas dos , Pumariega Yesica Nunez , Torres Catalina Dominga Pumariega , Silva Queila Rodrigues da , Silio Luís Felipe
Published: February 2022

O presente estudo tem como objetivo identificar, sistematizar e divulgar os resultados obtidos no esporte de rendimento nos últimos cinco anos no estado de Rondônia. Os dados foram levantados junto aos presidentes das federações esportivas do estado. Para tanto, elaborou-se um questionário formulado no Google Forms que foi enviado a 29 presidentes de federações. Destes, 21 participaram da pesquisa. Constatou-se que algumas modalidades esportivas têm se destacado com resultados exitosos, principalmente nos eventos nacionais. Entretanto, dentre os resultados conquistados, averiguou que se tratam de classificações pontuais, sem uma continuidade em anos subsequentes. A exceção deste fato é a modalidade de Ciclismo, que conquistou medalhas num mesmo evento esportivo nos anos 2018 e 2019; e em outra competição nos anos 2017, 2018, 2019; e a modalidade de Ginástica que apresentou resultados progressivos nos anos de 2015 a 2019.
DETERMINATION OF COST MANAGEMENT TOOLS FOR DAIRY ENTERPRISES
Authors:   Novgorod State University named after Yaroslav the Wise, Veliky Novgorod, Russia, Burova Irina A.
Published: February 2022

The author defines cost management tools for organizations engaged in the production of dairy products. The existing instrumental methods are described in terms of their advantages and disadvantages, compatibility and expediency of their application in the dairy industry. Based on the multi-criteria assessment, the main and auxiliary cost management tools are identified.
IFRS AND RAS, INTERNATIONAL HARMONIZATION AND STANDARDIZATION OF ACCOUNTING AND FINANCIAL REPORTING IN THE CONDITIONS OF GLOBALIZATION OF THE WORLD ECONOMY
Authors:   North Ossetian State University after K. L. Khetagurov, Vladikavkaz, Russia, Arkauti Vita V. , Tsgoev Konstantin K. ,   North Ossetian State University after K. L. Khetagurov, Vladikavkaz, Russia, Zubova Ekaterina V. ,   North Ossetian State University after K. L. Khetagurov, Vladikavkaz, Russia, Magkeev Soslan B. ,   North Ossetian State University after K. L. Khetagurov, Vladikavkaz, Russia, Kasaeva Lyubov V. ,   North-Caucasian Mining and Metallurgical Institute, Vladikavkaz, Russia
Published: February 2022

The article examines the significant changes that have occurred in the Russian practice of accounting and financial reporting, which are caused by the processes of globalization, digitalization of the world economy, convergence of Russian accounting standards (RAS) with international financial reporting standards (IFRS). The problems of reforming the system of legislative and legal acts of accounting, financial reporting in Russia during the transition to IFRS. The analysis of the key principles of efficiency, according to which modern Russian accountants work, is carried out.
VTB PJSC CORPORATE GOVERNANCE SYSTEM
Authors:   Financial University under the Government of the Russian Federation Vladikavkaz Institute of Management, Vladikavkaz, Russia, Tadtaeva Valida V. , Sitohova Tatyana E. ,   North Ossetian State University, Vladikavkaz, Russia, Bitieva Victoria V. ,   Financial University under the Government of the Russian Federation, Vladikavkaz, Russia
Published: February 2022

The article is devoted to the analysis of the corporate governance system in PJSC «VTB». The authors propose for the Supervisory Board of PJSC VTB to form a personnel reserve of the Supervisory Board using the possibility of candidates for work in the conditions of a particular bank, close to the conditions of the Supervisory Board. Representatives of shareholders and independent directors have the opportunity, working as part of an advisory body, to carry out their activities in conditions close to the work of the supervisory board, which will allow them to enter the state of affairs in the company and eliminate the need for their further adaptation when they are included in the supervisory board.
CORPORATE GOVERNANCE SYSTEM OF THE COMPANY
Authors:   Financial University under the Government of the Russian Federation Vladikavkaz Institute of Management, Vladikavkaz, Russia, Tadtaeva Valida V. , Tsallagova Lyudmila M. ,   North Ossetian State University, Vladikavkaz, Russia, Bitieva Victoria V. ,   Financial University under the Government of the Russian Federation, Vladikavkaz, Russia
Published: February 2022

The article is devoted to the study of the corporate governance system in the bank and the development of measures to improve its efficiency. The authors believe that the problems of developing corporate governance in banks are associated with a liquidity crisis, non-transparency of bank refinancing procedures and a decrease in confidence in the banking system. Corporate governance in Russian banks has been undergoing a new stage of development in recent years, which is aimed at eliminating gaps in ensuring the transparency of management and ownership. Building a corporate governance model in domestic banks, we took as a basis the principles of influential international organizations and used the best European practices.
Fundamental Features of Location of Service Centres in Czechoslovakia
Authors: Maryáš Jaroslav
Published: February 2022

The paper treats of the location of representative service centres, such as schools, health service institutions, local-authority services and retail business. Also the development of some coefficients and capacities in 1970-1983 is described.
The Development of Travelling and Recreation in Czechoslovakia and Its Territorial Organization
Authors: Vystoupil Jiří
Published: February 2022

The paper treats of the analysis and evaluation of effectual forms of the inland travelling and recreation (short and long-term travels, free, fixed-term travels, individual travels and recreation). It studies the development of the share of the population in travelling, local conditions, regional organization and the prospective development of free and fixed-term travelling in Czechoslovakia.
Process Analytical Technology (PAT) in Quality Assurance: A Detailed Review
Authors: Shah Esha Bhavin , Gajjar Anuradha
Published: February 2022

Process Analytical Technology (PAT) is a proactive initiative published by the Food  and Drug Administration so as to overcome the conventional way of batch testing.  As per the documented guideline it can be stated as a system for designing,  analyzing, and controlling pharmaceutical manufacturing through the timely  measurement of critical quality and performance parameters. PAT is a quality driven  approach with innovative, strategic and rapid systems, so as to clearly understand,  predict, manipulate, control and refine manufacturing processes. Owing to its  multidimensional applications, process analysis can be carried out even in the most  critical processes, like crystallization, by the on-line technique.PAT is one of the  prime objectives stressed in the Initiative for Pharmaceutical CGMPs for the 21st Century published by the Food and Drug Administration. The chief motive of this  dynamic approach is to carry out measurements on raw materials and in the in process materials or process parameters with tight controls, with a prime goal to  enhance final product quality and reduce the chances of error or default/defect. The  prime inventiveness of the PAT initiative is to focus on building quality inside the  product and the entire manufacturing processes, in addition to continuous process  improvement. The adoption of PAT approach can provide a plethora of benefits to  the pharmaceutical industry by enhancing product quality while providing  supercilious asset utilization and niche financial value. PAT bestows better insight of  raw materials, by characterizing it physically and chemically, detailed understanding  of manufacturing parameters, all of which collectively decide the fate of the quality  and appeal of the final product. Unlikely to the traditional approach of testing the  product at its terminal stage, PAT is a dynamic approach to keeping an eye on the  manufacturing and other related processes on a continuous basis compared to a  discrete one, and keeps a strict check at all stages of production. Hence this detailed  review will stress on the importance of PAT and its overall conceptualization, which  shall be indeed propitious for furnishing an integrated systems approach for quality  design, process analyses, understanding and control, continuous improvement,  knowledge and risk-based management within the FDA 21st century framework of  Good manufacturing initiative and will be a useful guide to the industry and  academia personnel for better understanding of this approach. Additionally it also  highlights the unique synergy of Quality by Design with PAT for establishing an in depth understanding of the manufacturing process.
Design and Characterization of Thermosensitive Mucoadhesive Nasal Gel for Meclizine Hydrochloride
Authors: Malviya Vedanshu
Published: February 2022

Background: The current study was to develop a thermoreversible nasal in-situ gel  for meclizine hydrochloride. As meclizine hydrochloride is water-insoluble and is  having a hepatic first-pass metabolism it becomes necessary to prepare a  formulation that will enhance the absorption of the drug and gives sustained action  in the body.  

Method: The FT-IR and DSC study revealed that there was no incompatibility  between the drug and the excipient. The inclusion complex of meclizine  hydrochloride was prepared by employing Sulfobutyl-ether- β- Cyclodextrin  (SBEβCD) and then using this complex the thermoreversible gel was prepared by  using the cold method. The thermoreversible gel was prepared by incorporating  various types of polymers like Carrageenan, HPMC, carbopol-934, and Sodium  Alginate in different concentrations and was evaluated for the various evaluation  parameters to identify the optimized formulation from the batches B1-B8.  

Result: From the prepared formulation B6 was found to be optimized as it was  having a higher drug concentration of 98.33±2.1547%, the mucoadhesive strength  of 28.98±1.5692 dyne/cm2 in B6 showed that more drug can be retained in the body  as compared with other formulations, more sustained release of drug was seen i.e.  87.42±1.4113% of drug release in 8 hours than compared with the other prepared  formulation. The kinetics study reveals peppas model was best fitted to the  optimized formulation with the regression coefficient of 0.9832. From the stability  study, it was concluded that the prepared formulation was stable during the full time study and does not change its property with time.  

Conclusion: The concentration of polymers was a significant factor in the % drug  release in the formulation and also in the mucoadhesive strength of the  formulation. Hence, it was concluded that the prepared thermoreversible nasal in situ gel was a successful approach in increasing the drug absorption in the body.
ANALISIS RISIKO KESEHATAN AKIBAT PAPARAN PARTIKEL DEBU (PM2.5) DARI AKTIVITAS TRANSPORTASI
Authors: Maksum Tri Septian , Tarigan Sylva Flora Ninta
Published: February 2022

Aktivitas transportasi yang tinggi berimplikasi kepada penurunan kualitas udara akibat keberadaan polutan di udara. Salah satu polutan di udara yang sangat berbahaya terhadap kesehatan manusia yaitu partikel debu berdiameter 2.5 µm (PM2.5). Tujuan penelitian untuk menganalisis tingkat risiko kesehatan akibat paparan partikel debu (PM2.5) dari aktivitas transportasi pada pedagang kaki lima di ruas jalan Kota Gorontalo. Jenis penelitian kuantitatif dengan menggunakan pendekatan analisis risiko kesehatan lingkungan (ARKL). Sampel sebanyak 81 responden yang diperoleh menggunakan teknik proporsional random sampling. Hasil penelitian menunjukkan bahwa konsentrasi rata-rata PM2.5 di empat lokasi yaitu area depan kampus UNG 0.01116 mg/m3, area Toko Madina Baru 0.02664 mg/m3, simpang lima Jalan Agus Salim 0.03682 mg/m3, dan Pasar Sentral 0.0144 mg/m3. Nilai intake realtime non karsinogenik berturut turut sebesar 1.43e-4 mg/kg/hari, 9.49e-4 mg/kg/hari, 6.44e-4 mg/kg/hari, dan 8.62e-4 mg/kg/hari. Tingkat risiko pedagang kaki lima akibat paparan PM2.5 yaitu tidak berisiko (RQ ≤ 1). Disarankan pedagang kaki lima agar tetap memakai masker untuk meminimalisasi potensi bahaya akibat paparan PM2.5.
THE EFFECTIVENESS OF TRAINING FROM HOME ON VO2MAX FEMALE VOLLEYBALL ATHLETES
Authors: Parengkuan Meyke , Lahay Abdul Rahman
Published: February 2022

This study aims to determine the effectiveness of Training From Home (TFH) on vo2max female volleyball athletes at SMP Negeri 13 Gorontalo City. This study uses a quasi-experimental approach that uses a population of all female athletes at SMP Negeri 13 Gorontalo, totaling 16 athletes, who were then divided into an experimental group and a control group of 8 athletes each who were randomly selected. This instrument uses the Multistage Fitness Test (MFT) and uses skipping as a treatment. Analysis of research data using paired sample t-test or t-test using SPSS 20. The results of this study can be concluded that there is a significant difference in the effectiveness of TFH exercise on VO2Max
Targeting the two-pore channel 2 in cancer progression and metastasis
Authors: Skelding Kathryn A. , Barry Daniel L. , Theron Danielle Z. , Lincz Lisa F.
Published: February 2022

The importance of Ca2+ signaling, and particularly Ca2+ channels, in key events of cancer cell function such as proliferation, metastasis, autophagy and angiogenesis, has recently begun to be appreciated. Of particular note are two-pore channels (TPCs), a group of recently identified Ca2+-channels, located within the endolysosomal system. TPC2 has recently emerged as an intracellular ion channel of significant pathophysiological relevance, specifically in cancer, and interest in its role as an anti-cancer drug target has begun to be explored. Herein, an overview of the cancer-related functions of TPC2 and a discussion of its potential as a target for therapeutic intervention, including a summary of clinical trials examining the TPC2 inhibitors, naringenin, tetrandrine, and verapamil for the treatment of various cancers is provided.
Halaman Depan JRJ Vol 14. No 2. 2021
Authors: Subandriyo Joko
Published: February 2022

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Predictive molecular genetic tests in clinical oncology
Authors: Ianus Grigorii , Iyevleva A.G. , Aleksakhina Svetlana , Imyanitov Evgeny
Published: February 2022

Molecular genetic testing is an essential component of modern practical oncology. It is aimed at individualized therapy prescription and can significantly improve the life expectancy of patients. The analyzed molecular events include alterations affecting single genes (EGFR, KRAS, etc.), as well as integral characteristics of tumor genome, for example, total tumor mutation burden (TMB) or deficiency of certain types of DNA repair (microsatellite instability, homologous DNA recombination deficiency, etc.). The spectrum of clinically relevant genetic markers continues to expand, and some of them acquire the status of "agnostic", i.e., applicable to tumors of various origin. As a consequence, there is a trend toward substitution of individual gene testing with the use of multigene panels allowing simultaneous assessment of all significant predictive markers.
Comparative analysis of the use of technetium-99m labeled recombinant target molecules at doses of 1000 and 2000 μg for radionuclide diagnostics of HER2-positive breast cancer
Authors: Bragina Olga , Chernov Vladimir , Deev Sergei , Zelchan Roman , Medvedeva Anna , Lukina Natalia , Goldberg Viktor , Tolmachev Vladimir
Published: February 2022

Materials and methods. The study included 18 patients with breast cancer (T1–4N0–2M0) before systemic treatment: 10 — with HER2/neu overexpression; 8 — HER2/neu negative. In all cases, morphological, immunohistochemical studies, as well as FISH analysis of the primary tumor were performed. All patients underwent radionuclide studies (planar scintigraphy and SPECT of the chest) at 2, 4, 6 and 24 hours after injection of the «99mTc-DARPinG3» in dosages of 1000 and 2000 μg.
Results. The half-life of the labeled protein from the blood was 3.5 hours for a dosage of 1000 μg; 3.8 h — for 2000 mcg. The organ with the highest absorption of «99mTc-DARPinG3» was the kidneys, regardless of the protein dose (0.10±0.02 and 0.10±0.03 mGy, respectively). The effective dose for 1000 μg was 0.011±0.001 mGy; for 2000 μg — 0.012±0.006. The liver absorption dose was significantly higher with 1000 μg of protein compared to 2000 μg (p<0.005, Mann–Whitney U test). The tumor/background ratio was significantly higher at 2 and 4 hours after administration of the «99mTc-DARPinG3» in patients with HER2-positive tumors in 1000 and 2000 μg doses of protein (p<0.005, Mann–Whitney U test).
Conclusion. Clinical studies of the «99mTc-DARPinG3» in dosages of 1000 and 2000 μg demonstrated rapid elimination from the bloodstream and effective doses comparable to those obtained in the study with others alternative scaffold proteins labeled with various isotopes. An essential point of this work is the positive correlation of the protein dose with the accumulation of the compound in the liver, which is important component in diagnostic and allows to detect tumor sites in liver.
Carcinogenic hazard of "non-carcinogenic" compounds
Authors: Belitsky Gennady , Kirsanov Kirill , Krivosheeva Leyla , Lesovaya Ekaterina , Solenova Liya , Yakubovskaya Marianna
Published: February 2022

Due to the high rates of industrialization, the biosphere is increasingly polluted by both complete carcinogens and compounds that are not able to induce a tumor on their own, but, as it turned out recently, cause changes in the cell corresponding to particular links in the chain of carcinogenesis. Some of these compounds are of great economic interest, and therefore an international agreement allows their unlimited production. At the same time, when combined, these "semi-carcinogens" can either cause malignant transformation or stimulate the action of ubiquitously widespread carcinogens. The saturation of the biosphere with such xenobiotics may be one of the universal factors of the observed increase in cancer incidence. In this regard, the practice of assessing the carcinogenic hazard of chemical compounds based on mechanistic signs should be changed, since it does not take into account the effect of the carcinogenic background of the environment. In vitro experiments should be carried out not only in standard purified media, but also with the addition of the sum of the main components of biospheric pollution in concentrations found, for example, in blood from the umbilical cord of newborns and breast milk. Such additives need to be created and standardized as is customary for Reference materials.
Meniti Idealisme Wartawan: Kegamangan yang Tak Pernah Selesai
Authors: Abrar Ana Nadhya
Published: February 2022

Kegamangan seorang wartawan atau jurnalistik tentunya tidak akan membunuh kreativitasnya. Bahkan dalam sistem yang sudah mapan pun, seorang wartawan tetap perlu memiliki kehati-hatian penggamang. Cuma bedanya, kehati-hatian ini akan menjadi sikap dalam menempatkan kehadirannya di tengah masyarakat. Kita ingatkan, kegiatan jurnalistik mengandung kualitas yang bersifat intelektualitas. Karena pelaku profesi ini akan memelihara wawasan yang terkait dengan perjalanan peradaban.
Scope of Tetrazolo[1,5-a]quinoxalines in CuAAC reactions for the Synthesis of Triazoloquinoxalines, Imidazoloquinoxalines, and Rhenium-complexes thereof
Authors: Holzhauer Laura , Liagre Chloé , Fuhr Olaf , Jung Nicole , Bräse Stefan
Published: February 2022

The conversion of tetrazolo[1,5-a]quinoxalines to 1,2,3-triazoloquinoxalines and triazoloimidazoquinoxalines under typical conditions of a CuAAC reaction has been investigated. Derivatives of the novel compound class of triazoloimidazoquinoxalines (TIQ) and rhenium(I) triazoloquinoxaline complexes as well as a new TIQ rhenium complex were synthesized. As a result, a small 1,2,3-triazoloquinoxaline library was obtained and the method could be expanded towards 4-substituted tetrazoloquinoxalines. The compatibility of various aliphatic and aromatic alkynes towards the reaction was investigated and the denitrogenative annulation towards imidazoloquinoxalines could be observed as a competing reaction depending on the alkyne concentration and the substitutions at the quinoxaline.
BIO ANALYTICAL METHOD FOR SIMULTANEOUS ESTIMATION OF EZETIMIBE AND PITAVASTATIN AND ITS APPLICATION TO PHARMACOKINETIC STUDIES USING UPLC
Authors:   Department of Engineering Chemistry, AUCE (A), Andhra University, Visakhapatnam- 530003, India, Prasanthi S , Himabindu G ,   Department of Engineering Chemistry, AUCE (A), Andhra University, Visakhapatnam- 530003, India
Published: February 2022

A simple, sensitive and rapid UPLC method was developed and validated for the simultaneous quantification of Ezetimibe and Pitavastatin. Separation was carried on C18 column (50x2.1mm, 1.7µ) using a isocratic elution with a buffer containing 1mL of Formic acid in 1Lit of water and the mixture of two components like Buffer and Acetonitrile in the ratio of 40:60 as mobile phase with 1mL/min flow rate at ambient temperature. Analysis was carried out within 10 minutes. The calibration curve was linear in the concentration range from 5.0ng/mL to 100ng/mL (r2 = 0.999) for Ezetimibe and 2.0ng/mL to 40ng/mL (r2 =0.999) for Pitavastatin. All the parameters of system suitability, specificity, linearity and accuracy are in good agreement with USFDA guidelines and applied effectively for the investigation of pharmacokinetic studies in rabbit. Simple and efficient method was developed and utilized in pharmacokinetic studies to see the investigated analyte in body fluids
The State of daymares and insomnias- Exploring the trepidation and Viciousness of Emergency in Rohinton Mistry’s A Fine Balance
Authors:   Assistant professor of English, University College of Engineering Nagercoil (Anna University Constituent College) Tamil Nadu, India, Latha Devi Dr R , Prabahar Dr S ,   Professor, Dept. of English, MS University, Tirunelvi, Tamilnadu
Published: February 2022

This paper intends to portray the problems that the ordinary people encountered during Internal Emergency that is represented in Rohinton Mistry‘s novel A Fine Balance. The Internal Emergency proclaimed during the regime of Indira Gandhi, the then Prime Minister of India forms the backdrop for Mistry’s novel A Fine Balance.. A Fine Balance, traces the social, political and historical development of India between the year of 1975 and 1985 and it portrays the horror and cruelty that was experienced by the people during the period. It entwines the story of four people who directly or indirectly become the victims of the Emergency. The novel draws the ruler in an unfavourable light and it abounds with the narration of many unhappy things. Detention of students, Evacuating slums, Forced vasectomy, Police brutality, Retaliatory murders were some of the cruel measures adopted during Emergency. The impact of these draconian measures is focused in A Fine Balance. Mistry proves himself a realist by representing what really was happening around
Faith, Scripture, and Reason : The Debate between Transylvanian Sabbatarians and Christian Francken
Authors: Újlaki-Nagy Réka
Published: February 2022

In this study, I present two Sabbatarian texts which were written in response to texts by Christian Francken. Based on the argumentation in the Sabbatarian texts, I try to clarify which writings by the German philosopher they were responding to. I offer an explanation of the ferocity of the Sabbatarian response, and I clarify the reasons why the Sabbatarians found it so important to respond to Francken’s ideas. My analysis of the Sabbatarian texts shows persuasively that Francken’s attacks were related to the basic and specific teachings of the Sabbatarians. The challenge presented by fashionable philosophical trends at the time compelled the Sabbatarians to face not only the benefits but also the dangers of following the ratio in the interpretation of Scripture. Sabbatarian texts arrived at a solution (by drawing a distinction between the concepts of ratio and philosophy) which, although formulated earlier in the established churches, was still undeveloped in the Transylvanian Antitrinitarian movement out of which Sabbatarianism grew.
Multiple Loyalties in Habsburg-Hungarian Relations at the Turn of the Fifteenth and Sixteenth Century
Authors: Péterfi Bence
Published: February 2022

In this essay, I examine how people with business and political interest on both sides of Austrian–Hungarian border, sometimes even in royal courts, could survive in spite of the rather capricious relationship between Hungarian kings and Habsburg rulers in the second half of the fifteenth century and the early sixteenth century. Most of them sought a solution that would enable them to keep the estates and the positions they had already acquired. This “double loyalty” was practically impossible in the midst of the war between Matthias Corvinus and Frederick III, Holy Roman emperor: very few of the figures in question managed to maintain attachments to both sides. A window of opportunity opened with the Peace of Pressburg in 1491, when the two parties recognized the possibility of service in the neighboring ruler’s service. Although the peace treaty did not alter the significant shrinking of the camp supporting the Habsburg claim to the throne, which had been relatively large in the time of the 1490–91 Austro-Hungarian War, from the 1490s on and in strikingly large numbers from the mid-1510s, more and more people could be found whose activities made plainly clear that they were not exclusive in their loyalties: they were quite able to serve two masters at the same time.
A Small Town’s Quest for Modernity in the Shadow of the Big City : The Case of Senj and Fiume
Authors: Eszik Veronika
Published: February 2022

Most of the theories concerning modernization and a number of trends in the historiography treat the big city as the most important arena of modernization, an arena which, thanks to our grasp of an array of social and economic transformations, can be made the ideal subject of studies on the processes and consequences of modernization. From this perspective, the small town becomes a kind of abstraction for backwardness, failed attempts to catch up, or a community that simply has remained unaffected by modernization. Thus, the study of the dynamics of modernization in smaller urban settlements from a new perspective which attributes genuine agency to them may well offer new findings and insights. In the historiography concerning the Austro-Hungarian Monarchy, the recent imperial turn has shown a perfectly natural interest in the peripheries of the empire, as it has striven to untangle the intertwining strands of local, regional, national, and imperial loyalties found there. The research on which this article is based, which focuses on Senj (Zengg), a small seaside Croatian city, is shaped by this dual interest. Senj’s resistance and adaptation to top-down initiatives of modernization can be captured through its conflict with the city of Fiume (today Rijeka, Croatia), which is not far from Senj and which before World War I belonged to Hungary. In this story, Fiume represents the “mainstream” manner of big-city modernization: it became the tenth most active port city in Europe over the course of a few decades. The area surrounding the city, however, was not able to keep up with this rapid pace of development. In this article, I present the distinctive program for modernization adopted by the elites of Senj, as well as their critique of modernization. Furthermore, the history of the city towards the end of the nineteenth century sheds light on the interdependencies among the cities of Austria–Hungary, interdependencies which were independent of legal or administrative borders. By analyzing relations between Senj and Fiume, I seek to offer a nuanced interpretation of the conflict between the two cities, which tends to be portrayed simply as a consequence of national antagonisms.
Political Readings of the 1956 Hungarian Revolution in Portugal
Authors: Sardica José Miguel
Published: February 2022

The 1956 Hungarian revolution had a resonant echo in Western Europe, gaining large attention and media coverage. This article explores how the small, peripheral Atlantic country of Portugal, on the other side of the European continent (Lisbon lies more than 3,000 kilometers from Budapest), which was under the rightwing conservative dictatorship of António de Oliveira Salazar’s New State at the time, became interested in the Hungarian events, allowing them to be written about in the most influential newspapers. The article begins with a discussion of the basic context of the Hungarian revolution of 1956 and of the Portuguese political context in the mid-1950s (the Salazarist regime and the bulk of the oppositional forces) and then offers an analysis of articles found in seven important Portuguese newspapers. Essentially, it presents a survey of the coverage of the Hungarian Revolution in the Portuguese press and explores how those events were interpreted and how they had an impact on the ideological readings and positions of the government, the moderate opposition, and the radical opposition of the Portuguese Communist Party (PCP). The 1956 revolution merited extensive coverage in the Portuguese papers, with titles, pictures, and news boxes on the front pages sometimes continuing into the next pages of a given paper or on the last page. The stories were narrated, for most part, in a lively, fluid, sentimental, and apologetic language. The New State in particular, but also moderate publications which were oppositional to Salazar, endorsed the Budapest revolutionaries and criticized and denounced orthodox communism in the form of Soviet repression, either in the name of Christendom, national independence, and the Western European safeguard against communism (in the case of Salazarism), or in the name (and hope) of a democratic surge, which would usher in strident calls for civil liberties (in the case of oppositional voices). With the exception of the press organ which voiced the official position of the Portuguese Communist Party, supporting the Soviet response against the Hungarian insurgents (and thus was in sharp contrast with the larger share of public opinion), there was a rare convergence, despite nuances in the language, in the images, narratives, messages, and general tone of the articles in the various organs of the Portuguese press, which tended to show compassion and support for the insurgents in Budapest because their actions targeted communism and tended to decry the final bloody repression, which exposed the Soviet Union as a murderous regime.
Comparing Surgical Advancement Outcomes of Retruded Maxilla in a Group of Egyptian Cleft Lip and Palate Subjects
Authors: Mossaad Aida M. , Abdelrahman Mostapha A. , Hassan Suzan A. , Al Ahmady Hatem H. , Adly Nahed M. , Ghanem Wael A. , Elsayed Shadia A.
Published: February 2022

BACKGROUND: Cleft lip and palate (CLP) is one of the most common congenital deformities involving intervention in several sub-specialties.
AIM: The present study was conducted to investigate the amount of maxillary advancement obtained by three different methods.
METHODS: A retrospective comparative study was conducted on 24 CLP patients who were treated with three surgical maxillary advancement techniques: Group A was treated with Le Fort I (LFI) orthognathic surgery with bone grafting and rigid fixation (LFI). Group B was treated with intraoral maxillary bone distraction (MIDO). Group C was treated with orthodontic traction by facemask (orthodontic facemasks [OFM]) plus corticotomy. All pre-operative data were collected, which included intraoral and extraoral clinical photos and dental casts. Pre-operative radiographic assessment was compared with post-operative values using digital panorama, multi-slice computed tomography and lateral cephalometric X-ray measuring Sella-nasion-A point; point A-nasion-point B points, with a follow-up period of 6 months.
RESULTS: All approaches showed statistically significant success in maxillary advancement with p < 0.01. LFI has produced the highest advancement obtained with regard to the pre-operative advancement required (8.6 ± 1.4) and post-operative advancement achieved (7.8 ± 0.8). MIDO technique is an alternative method to LFI, but it gives less achieved post-operative maxillary advancement (6.25 ± 0.8) and is indicated for moderate cases. OFM gave the least advancement results; however, it has been the most convenient less-invasive method and was more suitable for unsevere cases.
CONCLUSIONS: The three approaches produced satisfactory results in rehabilitating deficient maxilla in cleft patients, although each technique has limitations and indications. Future research is recommended to assess the technique’s long-term stability.