bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact on clinical outcomes of renin-angiotensin system inhibitors against doxorubicin-related toxicity in patients with breast cancer and hypertension: A nationwide cohort study in South Korea
Authors: Hwang Hui-Jeong , Lee Taek-Gu
Published: November 2023

Background

Although doxorubicin (DOX) is a commonly used potent chemotherapeutic agent in patients with breast cancer, its cardiotoxic effect is a concern, particularly in patients with hypertension. Antihypertensive renin-angiotensin system (RAS) inhibitors may potentially play a role in preventing overt heart failure (HF) due to DOX toxicity. This study aimed to evaluate whether the use of RAS inhibitors improves clinical outcomes in patients with hypertension and breast cancer undergoing DOX-containing chemotherapy.

Methods

A total of 54,344 female patients who were first diagnosed with breast cancer and initiated into DOX therapy between 2008 and 2015 were recruited from a nationwide Korean cohort. Patients were divided into two groups: with and without hypertension (HT, n = 10,789; non-HT, n = 43,555), and the RAS inhibitor group (n = 1,728) was sub-classified from the HT group. Two propensity score-matched cohorts were constructed to compare the clinical outcomes between non-HT and HT groups and between non-HT and RAS inhibitor groups. The primary outcome was the composite of HF and death.

Results

After propensity score matching, the HT group had a higher risk for HF (adjusted hazard ratio [HR] = 1.30, 95% confidence intervals [95% CI] = 1.09–1.55) compared to the non-HT group, but there was no significant difference in primary outcome between the two groups. The RAS inhibitor group had a lower risk for primary outcome (adjusted HR = 0.78, 95% CI = 0.65–0.94) and death (adjusted HR = 0.81, 95% CI = 0.66–0.99) compared to the non-HT group.

Conclusions

Hypertension is a risk factor for HF in patients with breast cancer undergoing DOX chemotherapy. However, the RAS inhibitors used to treat hypertension may contribute to decreased mortality and improved clinical outcomes.
Epidemiological analysis of anaplasmosis in cattle from Khyber Pakhtunkhwa, Pakistan
Authors: Badshah Farhad , Ullah Kalim , Kamal Mustafa , Rafiq Naseem , Usman Tahir , Ríos-Escalante Patricio R. De los , Said Mourad Ben
Published: November 2023

Background and Aim: Anaplasmosis, a tick-borne disease affecting livestock caused by the bacteria Anaplasma, poses a global concern. This study aimed to estimate the prevalence, spatiotemporal variation, and associated risk factors of anaplasmosis in cattle from the Bannu and Lakki Marwat districts of Khyber Pakhtunkhwa, Pakistan.

Materials and Methods: This study used 197 cattle exhibiting clinical symptoms of anaplasmosis in natural settings. Microscopic examination was used to estimate the prevalence. Potential risk factors, such as sampling regions and months, gender, breed, and age were studied.

Results: The study revealed an overall anaplasmosis prevalence of 19.79%. Bannu district exhibited a higher occurrence at 22.10%, compared to Lakki Marwat district at 17.64%. Young cattle (<2 years) demonstrated a notably higher incidence of anaplasmosis (26.78%) compared to adults (>5 years), which had a prevalence of 12.35% (p < 0.05). Female cattle (22.36%) were more susceptible than male cattle (11.11%). Prevalence peaked in June (45.71%) and was lowest in February (3.57%). Crossbred cattle had a higher prevalence (23.52%) than purebred cattle (11.47%).

Conclusion: Anaplasmosis can be effectively controlled using a comprehensive approach encompassing selective breeding for resilience, targeted care of young calves and females, effective tick control during warmer months, consistent use of insecticides, and proactive risk factor management. Raising awareness among farmers through diverse channels, including media, is pivotal to bolster tick-borne disease management strategies.

Keywords: anaplasmosis, biotic risk factors, cattle, Khyber Pakhtunkhwa, Pakistan, spatiotemporal variation.
A Complementary Frequency Selective Surface with Tri-Band Frequency Response for Applications in Wi-Fi and 5G
Authors:   Federal University of Rio Grande do Norte, Sousa Matheus Emanuel T. , da Silva Bruno Sátiro ,   Federal University of Rio Grande do Norte, de Andrade Humberto Dionísio ,   Federal Rural University of Semi-árido, Silva Maurício W. B. ,   Fluminense Federal University
Published: November 2023

In this paper we proposed a novel tri-band complementary frequency selective surface (CFSS) with a traditional geometry composed of double concentric rings. The choice of this geometry is because of its very good angular stability. The proposed resonant frequencies were 2.5 GHz, 3.5 GHz, and 4.5 GHz. The CFSS is low profile and presents angular stability and polarization independence. Simulations were performed using HFSS software and they are compared with the experimental results for validation purposes. A very good agreement is observed between them.
Impacts of thinning activities on boreal peatland forests
Authors:   University of Eastern Finland, Faculty of Science, Forestry and Technology, School of Forest Sciences, Lepilin Dmitrii
Published: November 2023

Boreal peatland forests are an important source of timber. Recently, timber harvesting has been extended to warmer months, resulting in machinery traffic over unfrozen soils, and leading to higher levels of soil disturbance, such as deeper ruts. Despite this, our knowledge of the impact of soil disturbance on peat physical properties and soil biochemistry is still limited. To address this gap, I conducted a study to examine the effects of soil disturbance caused by harvesting machinery during thinning operations on the soil physical, chemical, and biological properties and vegetation of drained boreal peatland forests. To assess the rate of recovery, I sampled six sites that formed a chronosequence covering 15 years since thinning. The results showed that soil disturbance caused an increase in the bulk density and field capacity of peat, along with a decrease in total porosity. In the vegetation, moss biomass and root production were reduced, but sedge cover increased. Furthermore, recently disturbed areas exhibited greater soil CO2 production potential, as well as higher soil CO2 and CH4 concentrations compared to control areas. However, CO2 and CH4 emissions, microbial communities, and cellulose decomposition rate were not impacted. Although the rate of recovery varied, all studied properties impacted by disturbance were fully recovered within 15 years. As the water retention characteristic (WRC) describes soil structure and its alterations, it a useful for disturbance assessment. Thus, I propose how WRC can be predicted using artificial neural networks. Overall, the study demonstrated that while drained boreal peatlands are sensitive to disturbance, they are also resilient to mechanical soil disturbance caused by thinnings.
The efficacy of translanguaging as pedagogic practice in selected Namibian multilingual primary classrooms
Authors:   University of Namibia, Mashinja Begani Ziambo , Mwanza David Sani ,   University of Zambia
Published: November 2023

This article aims to explore the initial literacy and epistemic benefits of translanguaging as a pedagogic practice in multilingual Namibia. Using notions of recontextualization and translanguaging and classroom observation and data from documents, the article shows how pre-primary teachers and learners draw on heteroglossic repertoires for literacy development and epistemic access. It is argued that this reframes the classroom, not as a site of monolingual epistemic violence, but as a democratic space for initial literacy and epistemic development. The article concludes with an argument for the legitimization of heteroglossic practices in multilingual Namibian classrooms if effective teaching and learning of initial literacy is the goal of basic education.
What Becomes of the Damned
Authors: Shields R. A. J.
Published: November 2023

Annihilationism provides a fruitful point of contact between philosophers and theologians for further reflection on nonexistence. In this paper I articulate a key commitment of annihilationism; namely, that some persons cease to exist. Such a commitment, I argue, amounts to the claim that some persons exist at time t and then do not exist at t+1, become ‘annihilated objects.’ Claims about annihilated objects induct the annihilationist into a wider realism/anti-realism debate about nonexistent objects. I survey some major viewpoints in this debate. I then draw out some implications for each view for the annihilationist’s commitment to annihilated objects. I show that annihilationism is consistent with some forms of realism and anti-realism and inconsistent with others.
Analisis Kenaikan Muka Air Laut dan Penurunan Muka Tanah untuk Perencanaan Tinggi Lantai Bangunan di Pesisir Utara Kota Semarang
Authors: Andnur Mohammad Octa , Widada Sugeng , Suryo Agus Anugroho Dwi
Published: November 2023

Penelitian ini merupakan bentuk kepedulian warga Semarang Utara terhadap banjir rob yang terus meningkat pertahunnya. Tujuan Penelitian ini mengetahui tingkat kenaikan muka air laut dan analisis yang dilakukan dengan pengamatan dan perhitungan, kemudian untuk menentukan laju penurunan muka tanah menggunakan citra satelit SAR Sentinel-1, dan untuk mengetahui nilai prediksi lantai bangunan tinggi pada tahun berikutnya. Kenaikan muka air laut diperoleh dengan cara menghitung dengan metode admiralty untuk mendapatkan nilai MSL dan HHWL dalam kurun waktu 5 tahun. Penentuan penurunan tanah menggunakan citra satelit sentinel-1 dengan mengolah citra menggunakan aplikasi snap yang menghasilkan penurunan tanah setiap tahunnya. Hasil penelitian ini menunjukkan bagaimana penurunan muka tanah dari tahun ke tahun meningkat secara signifikan ditambah MSL dan HHWL yang mengakibatkan wilayah pesisir mengalami penenggelaman terus menerus. Oleh karena itu solusi untuk menambah tinggi lantai bangunan sebesar 1,6 meter dalam jangka waktu 5 tahun merupakan solusi yang dapat digunakan warga Semarang Utara dalam menghadapi banjir rob yang terus meningkat setiap tahunnya. Kata kunci: Land Subsidence, Kota Semarang, Lantai Bangunan Abstract This research was as a form of concern for the residents of North Semarang towards tidal flooding which continued to increase every year. The objectives of this study were to determine the level of sea level rise with analysis carried out by observations and calculations, then to determine the rate of land subsidence based on SAR Sentinel-1 satellite imagery, and to determine the predicted value of high-rise floors in the following year. The sea level rise was obtained by calculating the admiralty method to get the MSL and HHWL values within a period of 5 years. The determination of land subsidence using sentinel-1 satellite imagery by processing images using a snap application resulted in land subsidence every year. The results of this study showed how land subsidence from year to year increased significantly plus MSL and HHWL which caused coastal areas to sustain continuous submergence. Therefore, the solution to increase the floor height of the building by 1.6 meters in a period of 5 years was a solution that could be used by the residents of North Semarang to deal with tidal floods, which continued to increase every year. Keywords: Land Subsidence, Semarang City, The Floors Building
Auch eine Geschichte der Offenbarung: Die Inspirationslehre als Herausforderung gegenwärtiger Theologie
Authors: Dausner René
Published: November 2023

The article is an approach to a temporary understanding of inspiration as a theological key concept. Starting with the difficulties of a theology of inspiration, the contribution follows three main questions: 1. How can the Holy Scriptures be understood as an inspired document of revelation? 2. How can the conviction of faith in the inspired Word of God be plausibly expressed? And finally, 3. How can the doctrine of inspiration be understood in the horizon of revelation? The contribution traces back to the Second Vatican Council (1962–1965) and suggests, according to phenomenological thinking, inspiration as a challenging hyperphenonemon that inspires a new way of thinking the word of God.
Il volto mariano della Chiesa e il volto ecclesiale di Maria nel pensiero di Joseph Ratzinger-Benedetto XVI
Authors: Havlík Petr
Published: November 2023

Our article seeks to highlight the connection between the Mother of the Lord and the theme of the Church in Ratzinger’s thought. It also reflects the Bavarian theologian’s approach to Mariology in the context of the development of theology in the second half of the 20th century, especially with regard to the importance of the Second Vatican Council and its ecclesiology. The main topics of interest include the biblical basis of our author’s ecclesiological Mariology, the relationship between the doctrine of the Church, Marian theology, and Christology, the mystery of the Covenant and the nuptial analogy as a correction of so-called christomonism and the feminine dimension of the Church, of which Mary is the image and personal concretisation.
Medición de la concentración de ertapenem en el plasma y líquido ascítico mediante UHPLC-MS/MS. Aplicación en pacientes cirróticos con peritonitis bacteriana espontánea
Authors: Rigo-Bonnin Raúl , Amador Alberto , Núñez-Gárate María , Mas-Bosch Virgínia , Padullés Ariadna , Cobo-Sacristán Sara , Castellote José
Published: November 2023

Objetivos

La peritonitis bacteriana espontánea es una complicación frecuente y grave de los pacientes cirróticos con ascitis. Actualmente, los antibióticos carbapenémicos son el tratamiento de elección en pacientes con peritonitis nosocomiales o relacionadas con el sistema sanitario. Pese a ello, los estudios de eficacia del ertapenem en pacientes cirróticos con peritonitis bacteriana espontánea son limitados y la farmacocinética y farmacodinamia de este antibiótico continúa siendo desconocida. Así, el objetivo de este estudio es desarrollar y validar procedimientos de medida basados en la cromatografía líquida de alta y rápida eficacia acoplada a la espectrometría de masas en tándem (UHPLC-MS/MS) para medir las concentraciones de ertapenem en el plasma y en el líquido ascítico.

Métodos

El pretratamiento de las muestras se realiza utilizando una precipitación de proteínas con acetonitrilo. La separación cromatográfica se lleva a cabo en una columna C18 de fase inversa Acquity®-UPLC®-BEHTM (2,1 × 100 mm id, 1,7 µm) utilizando un gradiente no lineal de agua/acetonitrilo que contiene un 0,1 % de ácido fórmico y an un flujo de 0,4 mL/min. El ertapenem y su patrón interno (ertapenem-D4) son detectados mediante espectrometría de masas en tándem en las modalidades de ionización mediante electroespray positiva y de monitorización múltiple de reacción utilizando, como transiciones de masa, 476,2→346,0/432,2 para el ertapenem y 480,2→350,0 para su patrón interno.

Resultados

No se observan interferencias ni contaminación por arrastre significativas. Las imprecisiones, los sesgos relativos absolutos, así como los efectos matriz y recuperaciones normalizadas son ≤14,5 %, ≤9,3 %, (92,8−104,5) % y (98,8−105,8) %, respectivamente. Los procedimientos de medida cromatográficos son lineales entre (0,50−100) mg/L.

Conclusiones

Los procedimientos de medida basados en la UHPLC-MS/MS desarrollados y validados podrían ser de utilidad para realizar estudios farmacocinéticos y farmacodinámicos en sujetos con cirrosis hepática que presentan peritonitis bacteriana espontánea tratados con ertapenem.
Specifications of qPCR based epigenetic immune cell quantification
Authors: Schildknecht Konstantin , Samans Björn , Gussmann Jasmin , Baron Udo , Raschke Eva , Babel Nina , Oppatt Julia , Gellhaus Katharina , Rossello Araceli , Janack Isabell , Olek Sven
Published: November 2023

Objectives

Immune monitoring is an important aspect in diagnostics and clinical trials for patients with compromised immune systems. Flow cytometry is the standard method for immune cell counting but faces limitations. Best practice guidelines are available, but lack of standardization complicates compliance with e.g., in vitro diagnostic regulations. Limited sample availability forces immune monitoring to predominantly use population-based reference intervals. Epigenetic qPCR has evolved as alternative with broad applicability and low logistical demands. Analytical performance specifications (APS) have been defined for qPCR in several regulated fields including testing of genetically modified organisms or vector-shedding.

Methods

APS were characterized using five epigenetic qPCR-based assays quantifying CD3+, CD4+, CD8+ T, B and NK cells in light of regulatory requirements.

Results

Epigenetic qPCR meets all specifications including bias, variability, linearity, ruggedness and sample stability as suggested by pertinent guidelines and regulations. The assays were subsequently applied to capillary blood from 25 normal donors over a 28-day period. Index of individuality (IoI) and reference change values were determined to evaluate potential diagnostic gains of individual reference intervals. Analysis of the IoI suggests benefits for individual over population-based references. Reference change values (RCVs) show that changes of approx. Fifty percent from prior measurement are suggestive for clinically relevant changes in any of the 5 cell types.

Conclusions

The demonstrated precision, long-term stability and obtained RCVs render epigenetic cell counting a promising tool for immune monitoring in clinical trials and diagnosis.
Optimal Pressure Recovery Using an Ultra-Weak Finite Element Method for the Pressure Poisson Equation and a Least-Squares Approach for the Gradient Equation
Authors: Pacheco Douglas R. Q. , Steinbach Olaf
Published: November 2023

Reconstructing the pressure from given flow velocities is a task
arising in various applications, and the standard approach uses the
Navier–Stokes equations to derive a Poisson problem for the pressure p.
That method, however, artificially increases the regularity requirements
on both solution and data. In this context, we propose and analyze two
alternative techniques to determine

p
∈

L
2

⁢

(
Ω
)

{p\in L^{2}(\Omega)}

. The first is an
ultra-weak variational formulation applying integration by parts to shift
all derivatives to the test functions. We present conforming finite element discretizations and prove optimal
convergence of the resulting Galerkin–Petrov method. The second approach
is a least-squares method for the original gradient equation, reformulated
and solved as an artificial Stokes system. To simplify
the incorporation of the given velocity within the right-hand side,
we assume in the derivations that the
velocity field is solenoidal. Yet this assumption is not restrictive,
as we can use non-divergence-free approximations and even
compressible velocities. Numerical experiments confirm
the optimal a priori error estimates for both methods considered.
Current clinical insights into circRNAs and signal transduction in diabetic nephropathy
Authors: Basudkar Vivek , Ajgaonkar Saiprasad , Mehta Dilip , Nair Sujit
Published: November 2023

Diabetic nephropathy (DN) is a chronic kidney disease that occurs in patients with diabetic mellitus. In the United States of America, one in three people with diabetes suffers from DN. Globally, DN occurs in 30%–40% of patients diagnosed with diabetes. Circular ribonucleic acids (circRNAs) are non-coding, closed-loop RNAs that play critical roles in regulating gene expression by sponging microRNAs (miRNAs). Recent studies have implicated circRNAs in the regulation of various diseases including DN. We delineate circRNA biological networks from the evidence gleaned from clinical studies. Further, we elucidate circRNA-associated signal transduction pathways in the pathogenesis of DN. Taken together, this will facilitate the discovery of novel circRNA and/or miRNA biomarkers for diagnostic and/or therapeutic intervention in DN.
Emerging perspectives and contemporary debates: assessing the landscape of online media communication research in Central Asia
Authors: Mammadov Rashad
Published: November 2023

This review essay offers an exhaustive examination of the multifaceted role of online media within the Central Asian context. Comprising 11 sections, the essay scrutinizes diverse facets of online media’s impact, spanning from its role in political dynamics to its implications for society, governance, national identity, cultural expression, and e-learning. By identifying recurring patterns, spotlighting ongoing debates, and revealing lacunae in extant scholarship, the essay aims to catalyze further research. Serving as an indispensable resource for scholars, policymakers, and those with an interest in the transformative potential of online media in Central Asia, the review underscores the complexity and dynamism inherent in the influence of online media within the region, fostering a more profound appreciation of this rapidly evolving field of study.
Microglia increase CEMIP expression and promote brain metastasis in breast cancer through the JAK2/STAT3 signaling pathway
Authors: Qin Qi , Wang Chaoying , Li Yongfu , Mo Qiuyu
Published: November 2023

Objectives

Brain metastasis is the most lethal metastatic site for patients with breast cancer, and the incidence of brain metastasis is increasing every year. Microglia act a pivotal part in promoting the proliferation and metastasis of breast cancer cells in the brain. Therefore, understanding the biological process of brain metastasis in breast cancer is important to improve therapeutic outcomes and prolong the survival of patients.

Materials and Methods

The role of microglia on the prognosis of patients with breast cancer with brain metastasis was verified by immunohistochemistry and the Kaplan–Meier curve. Cell experiments in vitro were used to analyze the effect of microglia on cell proliferation, migration and invasion. Knockdown of cell migration-inducing hyaluronan-binding protein (CEMIP) expression and co-culture experiments were carried out to study the mechanism of microglia on the progression of brain metastasis of breast cancer.

Results

We found that microglia may shorten the survival time of patients with breast cancer by regulating the expression of CEMIP in brain metastatic tumors. Co-culture experiments in vitro indicated that microglia enhance the proliferation, migration, and invasion abilities of brain metastatic breast cancer cells; however, the knockdown of CEMIP expression suppresses this effect. In addition, we also found that CEMIP expression, increased by microglia, activates the JAK2/STAT3 pathway in brain metastatic breast cancer cells, which induces the secretion of CCL2, IL-6, TGF-β, and VEGF. CCL2 recruits microglia to gather around brain metastases, whereas IL-6, TGF-β, and VEGF induce high CEMIP expression, triggering a positive feedback loop between microglia and brain metastatic breast cancer cells.

Conclusions

Our study proposes a possible mechanism of microglia promoting brain metastasis of breast cancer, indicating that both microglia and CEMIP may be valuable therapeutic targets for patients with breast cancer with brain metastasis.
Action at a Distance: Theoretical Mechanisms of Cross-Dendritic Heterosynaptic Modification
Authors: Moza Sahil
Published: November 2023

Highlighted Research Paper:T. Moldwin, M. Kalmenson, and I. Segev, “Asymmetric voltage attenuation in dendrites can enable hierarchical heterosynaptic plasticity.”eNeuro(2023).
Chronic Morphine Induces Adaptations in Opioid Receptor Signaling in a Thalamostriatal Circuit That Are Location Dependent, Sex Specific, and Regulated by μ-Opioid Receptor Phosphorylation
Authors: Jaeckel Elizabeth R. , Herrera Yoani N. , Schulz Stefan , Birdsong William T.
Published: November 2023

Chronic opioid exposure induces tolerance to the pain-relieving effects of opioids but sensitization to some other effects. While the occurrence of these adaptations is well understood, the underlying cellular mechanisms are less clear. This study aimed to determine how chronic treatment with morphine, a prototypical opioid agonist, induced adaptations to subsequent morphine signaling in different subcellular contexts. Opioids acutely inhibit glutamatergic transmission from medial thalamic (MThal) inputs to the dorsomedial striatum (DMS) via activity at μ-opioid receptors (MORs). MORs are present in somatic and presynaptic compartments of MThal neurons terminating in the DMS. We investigated the effects of chronic morphine treatment on subsequent morphine signaling at MThal–DMS synapses and MThal cell bodies in male and female mice. Surprisingly, chronic morphine treatment increased subsequent morphine inhibition of MThal–DMS synaptic transmission (morphine facilitation) in male, but not female, mice. At MThal cell bodies, chronic morphine treatment decreased subsequent morphine activation of potassium conductance (morphine tolerance) in both male and female mice. In knock-in mice expressing phosphorylation-deficient MORs, chronic morphine treatment resulted in tolerance to, rather than facilitation of, subsequent morphine signaling at MThal–DMS terminals, suggesting phosphorylation deficiency unmasks adaptations that counter the facilitation observed at presynaptic terminals in wild-type mice. The results of this study suggest that the effects of chronic morphine exposure are not ubiquitous; rather adaptations in MOR function may be determined by multiple factors such as subcellular receptor distribution, influence of local circuitry, and sex.
Developing Classroom Assessment Tasks That Evaluate Students’ Abilities to Plan Scientific Investigations
Authors: Chan Kennedy Kam Ho , Shun Ho Dickson Tik , Pan Lau David Siu , Tsui Ben Chi Shing
Published: November 2023

Designing classroom assessment tasks that can gather meaningful assessment information is a complex undertaking. This is especially the case when it comes to developing assessment tasks to evaluate students’ abilities to plan scientific investigations. Such assessment tasks should adequately elicit students’ cognitive understandings related to designing valid and reliable experiments, not just their hands-on manipulative skills. This article proposes a set of guidelines for developing written assessment tasks that can surface students’ cognitive understandings related to planning scientific investigations. We show how the checklist created based on the design guidelines can be used to analyze two classroom assessment tasks. The guidelines will be useful for teachers as they develop new or modify existing classroom assessment tasks to meaningfully evaluate students’ abilities to plan scientific investigations.
Using a News Event to Practice Self-Directed Investigation
Authors: Jin Hui , Xu Yifan , Liu Xingyou , Zhong Lichao , Shen Jie
Published: November 2023

On December 18, 2021, “hemorrhagic fever” appeared in the news, and it was thought to be related to eating strawberries. In this practice, based on the epidemic, we instructed students to conduct self-investigation on hemorrhagic fever and Hantavirus, and guided students to perform an objective analysis of “hemorrhagic fever.” This increases students’ motivation for active learning and interest in the course, and also improves students’ ability to obtain information and scientifically analyze the occurrence of epidemics.
A Fuzzy MARCOS-Based Analysis of Dragonfly Algorithm Variants in Industrial Optimization Problems
Authors: Kalita Kanak , Ganesh Narayanan , Shankar Rajendran , Chakraborty Shankar
Published: November 2023

Metaheuristics are commonly employed as a means of solving many distinct kinds of optimization problems. Several natural-process-inspired metaheuristic optimizers have been introduced in the recent years. The convergence, computational burden and statistical relevance of metaheuristics should be studied and compared for their potential use in future algorithm design and implementation. In this paper, eight different variants of dragonfly algorithm, i.e. classical dragonfly algorithm (DA), hybrid memory-based dragonfly algorithm with differential evolution (DADE), quantum-behaved and Gaussian mutational dragonfly algorithm (QGDA), memory-based hybrid dragonfly algorithm (MHDA), chaotic dragonfly algorithm (CDA), biogeography-based Mexican hat wavelet dragonfly algorithm (BMDA), hybrid Nelder-Mead algorithm and dragonfly algorithm (INMDA), and hybridization of dragonfly algorithm and artificial bee colony (HDA) are applied to solve four industrial chemical process optimization problems. A fuzzy multi-criteria decision making tool in the form of fuzzy-measurement alternatives and ranking according to compromise solution (MARCOS) is adopted to ascertain the relative rankings of the DA variants with respect to computational time, Friedman’s rank based on optimal solutions and convergence rate. Based on the comprehensive testing of the algorithms, it is revealed that DADE, QGDA and classical DA are the top three DA variants in solving the industrial chemical process optimization problems under consideration.
Pulmonary Vein Occlusion Requiring Lobectomy after Radiofrequency Catheter Ablation for Atrial Fibrillation: A Case Report and Review of the Literature
Authors: Jagelavičius Žymantas , Baužienė Ana , Jovaišas Vytautas , Janilionis Ričardas
Published: November 2023

Pulmonary vein stenosis is a potential complication after radiofrequency ablation for atrial fibrillation. We present an unusual case of this complication that progressed to vein occlusion and required lobectomy and review the literature. A 54-year-old man presented with persistent chest pain, dry cough, and hemoptysis. Seven months before he underwent radiofrequency catheter ablation for atrial fibrillation. Chest computed tomography showed a narrowing of the left lower pulmonary vein after the procedure. The patient was treated conservatively. On the presentation, a chest computed tomography scan showed total pulmonary vein occlusion. A quantitative ventilation/perfusion scan revealed no perfusion to the left lower lobe. A balloon angioplasty was performed, however unsuccessfully. The left lower lobectomy was performed. Six years after the lobectomy the patient has neither cardiac nor pulmonary symptoms. Pulmonary vein occlusion after radiofrequency ablation for atrial fibrillation leading to lung resection is still a possible severe complication.
Hepatic Angiomyolipoma: A Case Report and Review of the Literature
Authors: Strelčenko Jekaterina , Kuliavas Justas , Stratilatovas Eugenijus , Dulskas Audrius
Published: November 2023

Background. Hepatic angiomyolipomas are uncommon non-cancerous mesenchymal tumors that belong to the perivascular epithelioid cell tumour group. Smooth muscle cells, fat cells and blood vessels can be observed in these types of neoplasm. Case presentation. We present the case of a 50-year-old patient. The patient was referred to the National Cancer Institute after an abdominal ultrasound, which incidentally revealed a mass in the liver. A whole body computed tomography scan showed a large liver mass, in the VII/VIII/V/VI segments. Trisegmenthomy of the right liver lobe was performed. Pathological examination revealed a rare, but benign tumour – angiomyolipoma. The postoperative course was uneventful and the patient was discharged on postoperative day 9. Two months following the surgery, the patient has no recurrence or late complications. Conclusion. Hepatic angiomyolipoma is a rare, usually benign tumour with malignant potential. It is can be diagnosed by radiological tests, biopsy or after surgery. The most common treatment is surgical resection.
Experience in using heat storages in blackout conditions
Authors:   Institute of Engineering Thermophysics of NAS of Ukraine, 2a, Marii Kapnist St., Kyiv, 03057, Ukraine, Demchenko Volodymyr , Kovtun Svitlana ,   General Energy Institute of NAS of Ukraine, 172, Antonovycha St., Kyiv, 03150, Ukraine, Nazarenko Oleh ,   General Energy Institute of NAS of Ukraine, 172, Antonovycha St., Kyiv, 03150, Ukraine, Nazarenko Andrii ,   General Energy Institute of NAS of Ukraine, 172, Antonovycha St., Kyiv, 03150, Ukraine
Published: November 2023

This study is the first and so far the only one in Ukraine dedicated to the experience of using mobile thermal energy storage in emergencies, in particular blackouts. The article considers the issue of ensuring energy security. The classification of heat storage system parameters is given. The considered model of an autonomous heating system with a heat storage system. The impact on the thermal energy storage heating system with different designs of heat generators and fuel types is shown. The results of the operation of a combined system consisting of an autonomous heating system of a separate building equipped with an electric boiler and thermal energy storage are presented. Thermal energy storage is used not only as a buffer between the heat generator and the heating system but also as a source of heat. Integrating the thermal energy storage into the building's heating system ensures constant heat supply to the building, 100% coverage of peak dynamic loads, halving the boiler unit capacity and operating costs by 20%. It has been proven that the presence of thermal energy storage allows solving the problem of providing a stable heat supply in the conditions of a power outage. A detailed description of the conducted study of methods and equipment used during field operation and data processing is given. The results of the field tests of the thermal energy storage in winter operation conditions are provided. Features of the use of the controller for monitoring the heating system's operation with thermal energy storage are provided. The results of field tests are given. An analysis of the received data was carried out. Formulated directions for further scientific research, development, and practical recommendations for the use of mobile heat accumulators in the national economy and the state emergency service of Ukraine. Economic criteria and efficiency criteria aimed at reducing operational costs are considered. The obtained research results can be used to predict the operation of heating and cooling systems equipped with thermal energy storage. Keywords: Heating system, security, blackout, thermal energy storage, monitoring.
Study of the relationship of environmental and energy efficiency indicators at the country level
Authors:   General Energy Institute of NAS of Ukraine, 172, Antonovycha St., Kyiv, 03150, Ukraine, Maliarenko Olena , Ivanenko Nataliia ,   General Energy Institute of NAS of Ukraine, 172, Antonovycha St., Kyiv, 03150, Ukraine, Sudarykov Oleksandr ,   General Energy Institute of NAS of Ukraine, 172, Antonovycha St., Kyiv, 03150, Ukraine
Published: November 2023

The world community strives to develop methods of assessing the most important factors of environmental impact, as well as to develop mechanisms for its adjustment in order to reduce greenhouse gas emissions to the minimum possible level. Increasing environmental efficiency should simultaneously contribute to increasing energy efficiency, which in turn can contribute to increasing the general living standard. When choosing energy-saving measures in industrial technologies, the primary fuel savings and the economic effect of the implementation of the up-to-date technologies are taken into account. This effect, as a rule, includes the cost of saved energy resources, a reduction in operating costs and a reduction in environmental tax. The ecological restrictions determined by Ukraine in the 2021 National Determined Contribution should be taken into account for forecasting primary fuel consumption. As a result, this consumption is limited by the greenhouse gas emissions, which in 2030 should not exceed 35 % compared to 1990. The purpose of the study is to upgrade the existing methodology of comprehensive assessment of energy-saving measures with new environmental restrictions and improved performance indicators based on the identification and formalization of the relationship between energy and environmental indicators. The analysis of the existing environmental indicators and regulatory environmental documents made it possible to choose the environmental indicator of specific CO2 emissions per GDP for the methodology of comprehensive assessment at the country level, to study the regression dependence between this indicator and the fuel capacity of GDP. This graphic analysis allows for determining the marginal fuel capacity of GDP in 2030, which will correspond to the accepted environmental restrictions. Thus, the method of comprehensive assessment of energy-saving measures should be developed for different hierarchical levels of the economy and take into account the marginal fuel capacity of GDP under environmental restrictions. Keywords: GDP energy intensity, specific CO2 emissions, energy efficiency indicators, ecological restrictions.
Сучасні підходи до розробки типології неявних знань
Authors: Старікова Г. Г.
Published: November 2023

Неявна складова пізнання присутня в усіх без винятку видах людської діяльності – як в інтуїтивних діях «на рівні живої істоти», так і у специфічно людській діяльності – пізнавальній, практичній, творчій. Тому дослідження проблеми імпліцитного знання зали- шається актуальним для сучасної теорії пізнання та епістемології. Мета роботи – пошук загальних принципів підходу до розробки типології неявного знання на основі аналізу існуючих типологій. Для досягнення мети використовуються історико-генетичний та порівняльний методи. Розглядаються типи неявних знань, які запропоновані до нашого часу різними дослідниками: передумовні, практично-діяльнісні, ціннісно-оцінювальні, периферичні, інструментальні, парадигмальні та антипарадигмальні, витіснені, контекстні, редуковані, асоціативні тощо. Кожен з цих типів піддається аналізу, результатом якого стає висновок про відсутність єдиного принципу в розробці подібних типологій, єдиного критерію для виокремлення того чи іншого типу. Доведено, що недосконалість запропонованого переліку полягає насамперед в його лінійній структурі, яка не дозволяє врахувати всі реально існуючі взаємозв’язки між різними типами неявних знань. Розв’язати цю проблему можливо завдяки використанню багаторівневої схеми, у якій знайде своє відображення як специфіка кожного виду, так і відносини між ними, а також, що не менш важливо, особливості походження цих різновидів. На першому етапі розробки такої ти- пології ми пропонуємо використовувати дихотомічний принцип, який дозволяє робити послідовні кроки в процесі поділу неявних знань. Також звертається увага на ті різновиди неявних знань, які взагалі не стали об’єктами наукових або філософських досліджень. Це успадковані неявні знання, що мають біологічну природу, позаособистісні форми неявних знань, а також неявні знання, які пов’язані з функціонуванням природних мов. Ці та інші гіпотетичні пропозиції потребують подальшого глибокого дослідження та можуть стати основою для розробки повної типології неявних знань.
Non-volant mammals of the Serra da Fortaleza Wildlife Refuge, southern Goiás, central Brazil
Authors: Hannibal Wellington , Parreira Claro Hermes Willyan , Bernardes-Dias Ana Claudia , Alves Carolina , Bernardes Patricia Rezende , Silva Thaynara Lorrane Linhares da
Published: November 2023

Protected areas are essential for the maintenance of biodiversity, but we know little about local biodiversity in these areas. In this study, we describe the composition and structure of the non-volant mammal community in the Serra da Fortaleza Wildlife Refuge in southern Goiás state, central Brazil. We distributed 20 hexagons (~57 ha each), 10 in the protected area and 10 in its surroundings. We collected data on composition, richness, and abundance of non-volant mammals using live and pitfall traps, camera traps, and active searching. We recorded 39 species (five threatened) of non-volant mammals. The use of diverse sampling methods allowed for a com-prehensive depiction of mammal diversity and composition, lead to the discovery of new species records for the region, including Marmosa limae Thomas, 1920, Cerradomys scotti (Langguth & Bonvicino, 2002), Hylaeamys megacephalus (G. Fischer, 1814), and Tayassu pecari (Link, 1795). We emphasize the importance of protected areas for the conservation of the mammal fauna in the highly fragmented landscape of central Brazil.
Differentiating variation of chest pain in primary care patients: a literature review of ruling out cardiac and non-cardiac chest pain
Authors: Yogita Saraswati Putri
Published: November 2023

A common complaint with a wide range of differential diagnoses is chest pain. A non-life-threatening and life-threatening can cause chest pain. Before considering more benign causes, the first step is to focus on ruling out serious medical conditions. Visceral pain is generally described as dull, deep, throbbing, and oppressive but can also be referred elsewhere. Chest pain due to an ischemic heart disease is described as radiating chest pain from the left or right shoulder, jaw, or left arm. This review describes the different types of chest pain that play an important role in ruling out cardiac and non-cardiac chest pain, which is then essential for proper management.
Kasus dermatosis langka: confluent and reticulated papillomatosis pada seorang anak
Authors: Karmila I Gusti Ayu Agung Dwi , Saputra Herman , Putri Joice Gunawan , Indah Made Sanitca
Published: November 2023

Background: Confluent and reticulated papillomatosis (CARP) or Gougerot-Carteaud syndrome is a rare and chronic skin disorder characterized by hyperpigmented and cofluent papules/macules/plaques forming a reticular pattern. The characteristics especially occur in adolescents and young adults. Treatment of CARP is difficult and has not yielded good results. This case describes CARP in a young male patient.
Case: A 6-year-old male complained of brownish spots on his face, hands and feet since 5 years ago. It were initially appeared small without itching or pain. Dermatological exmaniation showed hyperpigmented macules, hyperpigmented plaques, confluent to form a reticular pattern. Dermoscopy examination showed a brownish appearance, homogeneous separated by white striae. Histopathological examination revealed acanthosis down growth, reticulated, mild distribution of lymphocytes and perivascular mast cells in the superficial and mild dermis. The patient was diagnosed with CARP and given intraoral azithromycin 250 mg every 24 hours for 2 weeks and ketoconazole 2% shampoo 3 times a week. Follow-up at week 4 there was no significant improvement.
Conslucion: Incident cases of CARP are rare, so there is no alternative therapy for the management of this disease. In this case, new lesions were found after administration of therapy and the prognosis for the patient was poor.
 
Latar belakang: Confluent and reticulated papillomatosis (CARP) atau sindrom Gougerot-Carteaud merupakan suatu kelainan kulit langka dan kronis dengan karakteristik papul/makula/plak hiperpigmentasi konfluen membentuk pola retikuler. Kelainan ini terutama pada remaja dan dewasa muda. Terapi CARP sulit dan belum memberikan hasil yang baik. Kasus ini mendeskripsikan CARP pada seorang anak laki-laki.
Kasus: Seorang anak laki-laki 6 tahun dengan keluhan bercak kecoklatan pada wajah, tangan dan kaki sejak 5 tahun lalu, awalnya muncul kecil, tanpa disertai gatal maupun nyeri. Status dermatologi didapatkan makula hiperpigmentasi, plak hiperpigmentasi, berkonfluens membentuk pola retikuler. Pemeriksaan dermoskopi didapatkan gambaran kecoklatan, homogen dipisahkan oleh striae putih. Pemeriksaan histopatologi didapatkan gambaran acanthosis down growth, reticulated, sebaran ringan limfosit dan sel mast perivascular pada superfisial dan mild dermis. Pasien didiagnosis CARP dan diberi terapi  Azitromisin 250 mg tiap 24 jam  intraoral selama 2 minggu dan ketokonazol 2% sampo 3 kali seminggu. Follow-up minggu ke-4 tidak terdapat perbaikan signifikan.
Simpulan: Insiden kasus CARP jarang ditemukan sehingga belum terdapat terapi pilihan untuk tatalaksana penyakit ini. Pada kasus ini masih ditemukan muncul lesi baru setelah pemberian terapi dan prognosis pada pasien adalah dubia ad malam.
Hubungan antara durasi tidur dengan kejadian obesitas pada anak: sebuah tinjauan sistematis
Authors: Hsieh Peter Prayogo , Sindhu Florencia Christina , Dewi Made Ratna , Sidhiarta I Gusti Lanang
Published: November 2023

Background: Obesity in children is a serious health problem with a rapidly increasing global prevalence. Children with obesity are at high risk of developing several metabolic diseases as adults. Studies show that short sleep duration is a risk factor for obesity. Short sleep duration will affect the diurnal rhythm and disrupt homeostasis and energy metabolism. This systematic review aims to determine the relationship between sleep duration and obesity in children.
Methods: A systematic literature review was carried out by literature searching on PubMed and Google Scholar using the PRISMA diagram and based on the eligibility criteria in selecting literature. The study was limited to the last five years (2017-2021). Studies that met the criteria were included in the analysis.
Results: There were 17 studies included in the analysis with cross sectional studies, prospective cohorts and clinical trials study designs regarding the relationship between sleep duration and obesity in children. All studies show a strong association between sleep duration and obesity in children and adolescents. The underlying mechanism is short sleep duration affects the balance of hormones controlling hunger and appetite so that appetite increases and causes excess energy intake, resulting in obesity. Children with short sleep duration are 2-4 times more prone to obesity compared to children with normal sleep duration.
Conclusion: There is a significant relationship between sleep duration and obesity in children and adolescents. Adequate sleep duration is recommended to prevent obesity and the risk of metabolic and cardiovascular diseases.