bluuebunny/crossref_metadata_2025 huggingface dataset:
Diverse Glial Cell Line-Derived Neurotrophic Factor (GDNF) Support Between Mania and Schizophrenia: A Comparative Study in Four Major Psychiatric Disorders
Authors: Tunca Z. , Kıvırcık Akdede B. , Özerdem A. , Alkın T. , Polat S. , Ceylan D. , Bayın M. , Cengizçetin Kocuk N. , Şimşek S. , Resmi H. , Akan P.
Published: December 2014

Background:

Brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) have essential roles in synaptic plasticity which is involved in pathogenesis and treatment of psychiatric disorders. However, it is not clear whether they act simultaneously during illness states in major psychiatric disorders.

Methods:

BDNF and GDNF serum levels were measured concomitantly by enzyme-linked immunosorbent assay (ELISA) method in 171 patients diagnosed with schizophrenia (n= 33), bipolar disorder-manic episode (n= 39), bipolar/unipolar depression (n= 64, 24/40) and obsessive-compulsive disorder (n= 35) according to DSM-IV, and 78 healthy volunteers. SCID-I and SCID non-patient version were used for clinical evaluation of the patients and healthy volunteers, respectively. Correlations between the two trophic factor levels, and illness severity scores, duration of illness and medication dosages were studied across different illnesses.

Results:

While patients had equally lower BDNF levels in all diagnoses, GDNF levels were significantly higher in mania and lower in schizophrenia compared to healthy controls. BDNF levels were negatively correlated to illness severity scores in affective episodes (mania and depression). Longer duration of illness (> 5 years) had an impact on lower GDNF levels in schizophrenia. BDNF levels and antipsychotic drug dosages in schizophrenia, and GDNF levels and antidepressant drug dosages in obsessive-compulsive disorder were positively correlated.

Conclusion:

Our data confirmed the evidence of equally deficient neuronal support by BDNF in all major psychiatric illnesses, but suggested a diverse glial functioning between schizophrenia and mania.
Low‐intensity pulsed ultrasound‐induced ATP increases bone formation via the P2X7 receptor in osteoblast‐like MC3T3‐E1 cells
Authors: Manaka Soichiro , Tanabe Natsuko , Kariya Taro , Naito Masako , Takayama Tadahiro , Nagao Mayu , Liu Di , Ito Koichi , Maeno Masao , Suzuki Naoto , Miyazaki Masashi
Published: December 2014

Low‐intensity pulsed ultrasound (LIPUS) is used for bone healing in orthopedics and dentistry. It has been shown that LIPUS induces the secretion of extracellular adenosine triphosphate (ATP), a key mediator of osteoblast response to mechanical stimuli. However, the detailed mechanism of LIPUS‐induced osteogenesis has been elusive. In this study, we investigated the role of the P2X7 receptor in LIPUS‐induced osteogenesis. LIPUS induced the release of extracellular ATP, differentiation of osteoblasts and osteogenesis via the P2X7 receptor, without affecting the activity of alkaline phosphatase (ALPase). These results suggest that LIPUS‐induced extracellular ATP promotes bone formation via the osteoblast P2X7 receptor independently of ALPase.
Soluble cysteine‐rich tick saliva proteins Salp15 and Iric‐1 fromE. coli
Authors: Kolb Philipp , Vorreiter Jolanta , Habicht Jüri , Bentrop Detlef , Wallich Reinhard , Nassal Michael
Published: December 2014

Ticks transmit numerous pathogens, including borreliae, which cause Lyme disease. Tick saliva contains a complex mix of anti‐host defense factors, including the immunosuppressive cysteine‐rich secretory glycoprotein Salp15 fromIxodes scapularis ticks and orthologs like Iric‐1 fromIxodesricinus. All tick‐borne microbes benefit from the immunosuppression at the tick bite site; in addition, borreliae exploit the binding of Salp15 to their outer surface protein C (OspC) for enhanced transmission. Hence, Salp15 proteins are attractive targets for anti‐tick vaccines that also target borreliae. However, recombinant Salp proteins are not accessible in sufficient quantity for either vaccine manufacturing or for structural characterization. As an alternative to low‐yield eukaryotic systems, we investigated cytoplasmic expression inEscherichia coli, even though this would not result in glycosylation. His‐tagged Salp15 was efficiently expressed but insoluble. Among the various solubility‐enhancing protein tags tested, DsbA was superior, yielding milligram amounts of soluble, monomeric Salp15 and Iric‐1 fusions. Easily accessible mutants enabled epitope mapping of two monoclonal antibodies that, importantly, cross‐react with glycosylated Salp15, and revealed interaction sites with OspC. Free Salp15 and Iric‐1 from protease‐cleavable fusions, despite limited solubility, allowed the recording of1H–15N 2D NMR spectra, suggesting partial folding of the wild‐type proteins but not of Cys‐free variants. Fusion to the NMR‐compatible GB1 domain sufficiently enhanced solubility to reveal first secondary structure elements in13C/15N double‐labeled Iric‐1. Together,E. coli expression of appropriately fused Salp15 proteins may be highly valuable for the molecular characterization of the function and eventually the 3D structure of these medically relevant tick proteins.
Mode of delivery and outcomes by birth weight among spontaneous and induced singleton cephalic nulliparous labors
Authors: Walsh Jennifer M. , Hehir Mark P. , Robson Michael S. , Mahony Rhona M.
Published: December 2014

Objective

To assess the effect of birth weight on mode of delivery among nulliparous women in a setting with no policy of elective induction for suspected macrosomia.

Methods

In an observational study, data were assessed from nulliparous women with a single cephalic pregnancy of at least 37 weeks in spontaneous (Robson group 1) and induced (Robson group 2a) labor attending a hospital in Dublin, Ireland, between January 1, 2008, and December 31, 2009. The primary outcome measure was mode of delivery.

Results

A total of 7528 nulliparous labors were included (4989 in group 1 and 2539 in group 2a). The cesarean section rate was 15.1% overall (n = 1139), with 411 (8.2%) in group 1, and 728 (28.7%) in group 2a. Cesarean delivery rates rose with increasing birth weight in group 1, from 119 (6.3%) of 1886 infants weighing 3000–3499 g and 160 (8.5%) of 1892 weighing 3500–3999 g, to 19 (26.8%) of 71 weighing 4500–4999 g. Rates of cesarean delivery were significantly higher in induced labor (group 2a) for each birth‐weight category, ranging from 202 (25.9%) of 781 weighing 3000–3499 g and 243 (27.0%) of 899 weighing 3500–3999 g, to 38 (48.1%) of 79 weighing 4500–4999 g (P < 0.01 for all).

Conclusion

In a setting with standardized management of labor, birth weight remains a significant determinant of mode of delivery.
Gene expression profiling of lobular carcinoma in situ reveals candidate precursor genes for invasion
Authors: Andrade Victor P. , Morrogh Mary , Qin Li-Xuan , Olvera Narciso , Giri Dilip , Muhsen Shirin , Sakr Rita A. , Schizas Michail , Ng Charlotte K.Y. , Arroyo Crispinita D. , Brogi Edi , Viale Agnes , Morrow Monica , Reis-Filho Jorge S. , King Tari A.
Published: December 2014

Purpose

Lobular carcinoma in situ (LCIS) is both a risk indicator and non‐obligate precursor of invasive lobular carcinoma (ILC). We sought to characterize the transcriptomic features of LCIS and ILC, with a focus on the identification of intrinsic molecular subtypes of LCIS and the changes involved in the progression from normal breast epithelium to LCIS and ILC.

Methods

Fresh‐frozen classic LCIS, classic ILC, and normal breast epithelium (N) from women undergoing prophylactic or therapeutic mastectomy were prospectively collected, laser‐capture microdissected, and subjected to gene expression profiling using Affymetrix HG‐U133A 2.0 microarrays.

Results

Unsupervised hierarchical clustering of 40 LCIS samples identified 2 clusters of LCIS distinguished by 6431 probe sets (p < 0.001). Genes identifying the clusters included proliferation genes and other genes related to cancer canonical pathways such as TGF beta signaling, p53 signaling, actin cytoskeleton, apoptosis and Wnt‐Signaling pathway. A supervised analysis to identify differentially expressed genes (p < 0.001) between normal epithelium, LCIS, and ILC, using 23 patient‐matched triplets of N, LCIS, and ILC, identified 169 candidate precursor genes, which likely play a role in LCIS progression, including PIK3R1, GOLM1, and GPR137B. These potential precursor genes map significantly more frequently to 1q and 16q, regions frequently targeted by gene copy number alterations in LCIS and ILC.

Conclusion

Here we demonstrate that classic LCIS is a heterogeneous disease at the transcriptomic level and identify potential precursor genes in lobular carcinogenesis. Understanding the molecular heterogeneity of LCIS and the potential role of these potential precursor genes may help personalize the therapy of patients with LCIS.
Feasibility of a Cost‐Effective, Video Analysis Software–Based Mobility Protocol for Objective Spine Kinematics and Gait Metrics: A Proof of Concept Study
Authors: Paul Justin C. , Petrizzo Anthony , Rizzo John‐Ross , Bianco Kristina , Maier Stephen , Errico Thomas J. , Lafage Virginie
Published: December 2014

The purpose of this study was to investigate the potential of a high‐throughput, easily implemented, cost‐effective, video analysis software–based mobility protocol to quantify spine kinematics. This prospective cohort study of clinical biomechanics implemented 2‐dimensional (2D) image processing at a tertiary‐care academic institution. Ten healthy, able‐bodied volunteers were recruited for 2D videography of gait and functional motion. The reliability of a 2D video analysis software program for gait and range of motion metrics was evaluated over 2 independent experimental sessions, assessing for inter‐trial, inter‐session, and inter‐rater reliability. Healthy volunteers were evaluated for simple forward and side bending, rotation, treadmill stride length, and more complex seated‐to‐standing tasks. Based on established intraclass correlation coefficients, results indicated that reliability was considered good to excellent for simple forward and side bending, rotation, stride length, and more complex sit‐to‐standing tasks. In conclusion, a cost‐effective, 2D, video analysis software–based mobility protocol represents a feasible and clinically useful approach for objective spine kinematics and gait metrics. As the complication rate of operative management in the setting of spinal deformity is weighed against functional performance and quality of life measures, an objective analysis tool in combination with an appropriate protocol will aid in clinical assessments and lead to an increased evidence base for management options and decision algorithms.
Usefulness of Vitamin A Isotope Methods for Status Assessment: From Deficiency through Excess
Authors: Tanumihardjo Sherry A.
Published: December 2014

A variety of methods exist to assess vitamin A status of groups and populations. Vitamin A status is usually defined by the liver retinol concentration. Most indicators of status do not measure or estimate liver stores of retinol. Clinical signs only have utility when liver reserves are almost exhausted, and serum retinol concentrations have utility in the zone of overt deficiency. Dose response tests offer more coverage, but cannot distinguish among liver vitamin A stores in the adequate through toxic range. Different countries continue, or are beginning, to add preformed vitamin A to a variety of staple foods through fortification, and vitamin A supplements are still being distributed in many countries, especially to preschool children. Further, provitamin A biofortified crops are currently being released in several countries. Assessing population vitamin A status in response to these interventions needs to move beyond serum retinol concentrations. Indicators that work in the excessive to toxic range of liver reserves are needed. To date, the only indirect indicator that has been validated in this range of liver reserves in animals and humans is the retinol isotope dilution test using deuterium or 13C, which spans the entire liver reserve continuum from deficiency through excess.
International Experiences in Assessing Vitamin A Status and Applying the Vitamin A-Labeled Isotope Dilution Method
Authors: Lopez-Teros Veronica , Chileshe Justin , Idohou-Dossou Nicole , Fajarwati Tetra , Medoua Nama Gabriel , Newton Sam , Vinod Kumar Malavika , Wang Zhixu , Wasantwisut Emorn , Hunt Janet R.
Published: December 2014

Inadequate vitamin A (VA) nutrition continues to be a major problem worldwide, and many interventions being implemented to improve VA status in various populations need to be evaluated. The interpretation of results after an intervention depends greatly on the method selected to assess VA status. To evaluate the effect of an intervention on VA status, researchers in Cameroon, India, Indonesia, Mexico, Senegal and Zambia have used serum retinol as an indicator, and have not always found improvement in response to supplementation. One problem is that homeostatic control of serum retinol may mask positive effects of treatment in that changes in concentration are observed only when status is either moderately to severely depleted or excessive. Because VA is stored mainly in the liver, measurements of hepatic VA stores are the gold standard for assessing VA status. Dose response tests such as the relative dose response (RDR) and the modified relative dose response (MRDR), allow a qualitative assessment of VA liver stores. On the other hand, the use of the vitamin A-labeled isotope dilution (VALID) technique, (using 13C or 2H-labeled retinyl acetate) serves as an indirect method to quantitatively estimate total body and liver VA stores. Countries including Cameroon, China, Ghana, Mexico, Thailand and Zambia are now applying the VALID method to sensitively assess changes in VA status during interventions, or to estimate a populations dietary requirement for VA. Transition to the use of more sensitive biochemical indicators of VA status such as the VALID technique is needed to effectively assess interventions in populations where mild to moderate VA deficiency is more prevalent than severe deficiency.
Differential impact of diabetes mellitus type II and arterial hypertension on collateral artery growth and concomitant macrophage accumulation
Authors: Ito Wulf D. , Lund Natalie , Sager Hendrik , Becker Wiebke , Wenzel Ulrich
Published: December 2014

Background: Diabetes mellitus type II and arterial hypertension are major risk factors for peripheral arterial disease and have been considered to reduce collateral growth (arteriogenesis). Collateral growth proceeds through different stages. Vascular proliferation and macrophage accumulation are hallmarks of early collateral growth. Material and methods: We here compare the impact of arterial hypertension and diabetes mellitus type II on collateral proliferation (Brdu incorporation) and macrophage accumulation (ED 2 staining) as well as collateral vessel function (collateral conductance) in a rat model of peripheral vascular disease (femoral artery occlusion), diabetes mellitus type II (Zucker fatty diabetic rats and Zucker lean rat controls) and arterial hypertension (induced via clip placement around the right renal arteriy). We furthermore tested the impact of monocyte chemoattractant protein-1 (MCP‑1) on collateral proliferation and macrophage accumulation in these models Results: Diabetic animals showed reduced vascular proliferation and macrophage accumulation, which however did not translate into a change of collateral conductance. Hypertensive animals on the contrary had reduced collateral conductances without altered macrophage accumulation and only a marginal reduction in collateral proliferation. Infusion of MCP‑1 only enhanced vascular proliferation in diabetic animals. Conclusions: These findings illustrate that impaired monocyte/macrophage recruitment is responsible for reduced collateral growth under diabetic conditions but not in arterial hypertension suggesting that diabetes mellitus in particular affects early stages of collateral growth whereas hypertension has its impact on later remodeling stages. Successful pro-arteriogenic treatment strategies in a patient population that presents with diabetes mellitus and arterial hypertension need to address different stages of collateral growth and thus different molecular and cellular targets simultaneously.
Zusammenhänge zwischen familialen Aspekten und pathologischem Internetgebrauch bei Jugendlichen
Authors: Wartberg Lutz , Aden Anneke , Thomsen Monika , Thomasius Rainer
Published: December 2014

Einleitung: Neben einer generellen Nutzung digitaler Medien durch Kinder und Jugendliche ist in vielen Industrieländern (insbesondere in Asien, Europa und Nordamerika) ein pathologischer Gebrauch des Internets ein Phänomen von wachsender Bedeutung. Aktuellen epidemiologischen Daten zufolge sind in Deutschland Jugendliche häufiger betroffen als Erwachsene. International wurden in verschiedenen Studien Zusammenhänge von familialen Interaktionsmustern und pathologischer Internetnutzung bei Jugendlichen untersucht. Dieser Beitrag gibt eine Übersicht über die aktuell vorliegenden Forschungsbefunde. Methodik: Es erfolgte eine systematische Literaturrecherche in den Datenbanken PubMed, PsycINFO und Psyndex mit festgelegten Schlagwörtern. Ergebnisse: Insgesamt wurden 15 Untersuchungen zu dieser Thematik identifiziert. Es wurden alle Originalarbeiten eingeschlossen, die in englischer oder deutscher Sprache verfasst und in denen ausschließlich minderjährige Untersuchungsteilnehmer befragt worden waren. Funktionalität der Familie, eine gute Kommunikation zwischen Eltern und Kind, eine positive Eltern-Kind-Beziehung sowie unterstützendes elterliches Monitoring vermindern das Risiko einer jugendlichen pathologischen Internetnutzung. Diskussion: Die beschriebenen familialen Prädiktoren wurden in mehreren Studien repliziert. Implikationen für die zukünftige Forschung zu dieser Thematik werden diskutiert.
Eine Pilotstudie zur Spezifität der Körperbildstörung für Anorexia nervosa
Authors: Rost (geteilte Erstautorenschaft) Silke , Sarrar (geteilte Erstautorenschaft) Lea , Schneider Nora , Klenk Vera , Staab Doris , Pfeiffer Ernst , Lehmkuhl Ulrike , Jaite Charlotte
Published: December 2014

Fragestellung: Die Körperbildstörung (KBS) gilt als Kernmerkmal der Anorexia nervosa (AN). Jedoch werden Hinweise auf körperbildbezogene Störungen u. a. bei an Mukoviszidose (Cystische Fibrose, CF) erkrankten, oftmals untergewichtigen, Patientinnen gefunden. Die Pilotstudie soll zur Klärung der Spezifität der KBS für AN beitragen. Methodik: Es wurden 22 Patientinnen mit AN, 10 Patientinnen mit CF sowie 23 Kontrollprobandinnen hinsichtlich der perzeptiven und kognitiv-affektiven Komponente der KBS untersucht sowie essstörungsrelevante Psychopathologie erfasst. Ergebnisse: Sämtliche Patientinnen mit AN sowie drei Patientinnen mit CF zeigten im Expertenurteil eine KBS. Patientinnen mit CF nahmen sich signifikant dünner wahr als Kontrollprobandinnen. Während Kontrollprobandinnen eine höhere Körperzufriedenheit als Patientinnen mit CF aufwiesen, ergaben sich diesbezüglich keine Unterschiede zwischen den Patientengruppen. Hinsichtlich essstörungsspezifischer Psychopathologie unterschieden sich die Patientengruppen im Schlankheitsstreben, der Unzufriedenheit mit dem Körper und der Unsicherheit in der Wahrnehmung der Gefühle mit höherer Symptomausprägung bei Patientinnen mit AN. Schlussfolgerungen: Unsere Ergebnisse liefern keine Hinweise auf schwerwiegende Auffälligkeiten im Körperbild bei Patientinnen mit CF. Vielmehr ist eine allgemeine Körperunzufriedenheit zu verzeichnen, die im Zusammenhang mit dem Vorliegen des Untergewichts interpretiert werden kann. Die KBS kann weiterhin als zentrales Diagnosekriterium der AN angesehen werden und sollte im Rahmen therapeutischer Interventionen eine besondere Bedeutung beigemessen werden.
Competitive evaluation of data mining algorithms for use in classification of leukocyte subtypes with Raman microspectroscopy
Authors: Maguire A. , Vega-Carrascal I. , Bryant J. , White L. , Howe O. , Lyng F. M. , Meade A. D.
Published: December 2014

In this study Raman spectral data from peripheral blood mononuclear cells (PBMCs) is used for the competitive evaluation of three data-mining models in discriminating a highly pure population of T-cell lymphocytes from other myeloid cells within the PBMCs fraction.
A turn-on fluorescent probe for hypochlorous acid based on the oxidation of diphenyl telluride
Authors: Venkatesan Parthiban , Wu Shu-Pao
Published: December 2014

A fluorescent probeHCTewas developed for rapid detection of hypochlorous acid based on the specific HOCl-promoted oxidation of diphenyl telluride.
Covalent coupling via dehalogenation on Ni(111) supported boron nitride and graphene
Authors: Morchutt Claudius , Björk Jonas , Krotzky Sören , Gutzler Rico , Kern Klaus
Published: December 2014

Polymerization of 1,3,5-tris(4-bromophenyl)benzene on graphene and hexagonal boron nitride is investigated by scanning tunnelling microscopy and density functional theory.
Site-specific tagging proteins via a rigid, stable and short thiolether tether for paramagnetic spectroscopic analysis
Authors: Yang Yin , Wang Jin-Tao , Pei Ying-Ying , Su Xun-Cheng
Published: December 2014

The reaction of phenylsulfonated pyridine derivatives and protein thiols is suitable for high-resolution spectroscopic analysis by generation of a rigid, stable and short thiolether tether.
Discovery of two new classes of potent monoamine oxidase-B inhibitors by tricky chemistry
Authors: Cagide F. , Silva T. , Reis J. , Gaspar A. , Borges F. , Gomes L. R. , Low J. N.
Published: December 2014

Discovery of monoamine oxidase-B inhibitors based on chromane-2,4-dione and chromone-3-carboxamide scaffolds for the management of neurodegenerative diseases.
Geminal dihalogen isosteric replacement in hydrated AI-2 affords potent quorum sensing modulators
Authors: Guo Min , Zheng Yue , Terell Jessica L. , Ad Michal , Opoku-Temeng Clement , Bentley William E. , Sintim Herman O.
Published: December 2014

Geminal dibromo moiety can replace hydrated carbonyl groups in AI-2, a quorum sensing autoinducer, without diminution of activity. This group can form halogen bond with active site electron donor.
The electrochemical transfer of CVD-graphene using agarose gel as solid electrolyte and mechanical support layer
Authors: Zhang Dayong , Jin Zhi , Shi Jingyuan , Wang Xuanyun , Peng Songang , Wang Shaoqing
Published: December 2014

An electrochemical method using agarose gel as a solid electrolyte was introduced to realize the eco-friendly transfer of CVD-graphene.
A near-infrared light-controlled system for reversible presentation of bioactive ligands using polypeptide-engineered functionalized gold nanorods
Authors: Yang Jie , Yao Ming-Hao , Du Ming-Shuo , Jin Rui-Mei , Zhao Dong-Hui , Ma Jun , Ma Zhi-Ya , Zhao Yuan-Di , Liu Bo
Published: December 2014

A hybrid platform with polypeptide-engineered functionalized gold nanorods has been designed for reversible presentation of immobilized bioactive ligands by near-infrared light.
Gating of responsive multiple nanochannels by ultra-low concentration of saccharides
Authors: Wang Hui , Yan Meng , Zhang Mingxi
Published: December 2014

We report a saccharide recognition system by modifying responsive copolymers on the solid-based multiple nanochannels.
A two-dimensional four-fold symmetric SrMoO4 dendrite
Authors: Jung Hye-Yun , Huh Young-Duk
Published: December 2014

The morphology evolution of SrMoO4 microcrystals was obtained from a tetragonal bipyramid to a 3-D cross-like dendrite, and finally to a 2-D four-fold symmetric dendrite.
Probing a chemical compass: novel variants of low-frequency reaction yield detected magnetic resonance
Authors: Maeda Kiminori , Storey Jonathan G. , Liddell Paul A. , Gust Devens , Hore P. J. , Wedge C. J. , Timmel Christiane R.
Published: December 2014

We present a new spectroscopic technique to characterise a model chemical compass. The data obtained inform the interpretation of animal behaviour studies into the origin of avian magnetoreception.
Photoresponsive ionic liquid crystals based on azobenzene guanidinium salts
Authors: Wuckert Eugen , Harjung Marc D. , Kapernaum Nadia , Mueller Carsten , Frey Wolfgang , Baro Angelika , Giesselmann Frank , Laschat Sabine
Published: December 2014

The mesomorphic properties and the kinetics of the E/Z-photoisomerization in an ILC matrix of new azobenzene ILCs were investigated.
Enhanced removal performance of arsenate and arsenite by magnetic graphene oxide with high iron oxide loading
Authors: Yu Fei , Sun Sainan , Ma Jie , Han Sheng
Published: December 2014

Magnetic iron oxide/graphene oxide adsorbents with high iron loading were synthesized for the removal of arsenic from aqueous solutions.
Thickness-dependent structural arrangement in nano-confined imidazolium-based ionic liquid films
Authors: Rouha Michael , Cummings Peter T.
Published: December 2014

Nano-confined ionic liquid interfacial layers showing lateral and perpendicular structural changes dependent on thickness of adsorbed film.
Nanoscale interface engineering in ZnO twin nanorods for proposed phonon tunnel devices
Authors: Singh Avanendra , Senapati Kartik , Satpati Biswarup , Kumar Mohit , Sahoo Pratap K.
Published: December 2014

Crystalline–amorphous–crystalline junction nanorods synthesized using a hydrothermal route with nanoscale interface tunability achieved via the temperature ramping rate (Rr) of the aqueous solution, prior to attainment of the reaction temperature.
Validation of Koopmans' theorem for density functional theory binding energies
Authors: Pueyo Bellafont Noèlia , Illas Francesc , Bagus Paul S.
Published: December 2014

Koopman's theorem does not hold for Kohn–Sham orbital energies but does provide correct shifts with respect to a given reference.
Synthesis of phosphinoferrocene amides and thioamides from carbamoyl chlorides and the structural chemistry of Group 11 metal complexes with these mixed-donor ligands
Authors: Fernandes Tiago A. , Solařová Hana , Císařová Ivana , Uhlík Filip , Štícha Martin , Štěpnička Petr
Published: December 2014

Phosphinoferrocene carboxamides and thioamides coordinate “ligand-free” Cu(i) and Ag(i) ions in chelating manner to form hemilabile cationic bis-chelate or a unique ligand-bridged dimer.
Synthesis and characterization of substituted Schiff-base ligands and their d10 metal complexes: structure-induced luminescence tuning behaviors and applications in co-sensitized solar cells
Authors: Dong Yu-Wei , Fan Rui-Qing , Wang Ping , Wei Li-Guo , Wang Xin-Ming , Zhang Hui-Jie , Gao Song , Yang Yu-Lin , Wang Yu-Lei
Published: December 2014

The structure-induced luminescence tuning behaviors of Schiff-base ligand based d10 metal complexes and their applications in co-sensitized solar cells.
Natural borneol enhances bisdemethoxycurcumin-induced cell cycle arrest in the G2/M phase through up-regulation of intracellular ROS in HepG2 cells
Authors: Chen Jianping , Li Lin , Su Jianyu , Chen Tianfeng
Published: December 2014

Natural borneol and bisdemethoxycurcumin in combination induces G2/M phase arrest in HepG2 cells.
Stachyose-induced apoptosis of Caco-2 cells via the caspase-dependent mitochondrial pathway
Authors: Huang Guidong , Mao Jian , Ji Zhongwei , Ailati Aisikaer
Published: December 2014

Some studies have shown that stachyose, as prebiotics, can prevent indirectly colon cancer cell growth by promoting the proliferation of probiotics or producing beneficial materials in the intestine.
Egg proteins as allergens and the effects of the food matrix and processing
Authors: Benedé S. , López-Expósito I. , Molina E. , López-Fandiño R.
Published: December 2014

Hen eggs are an important and inexpensive source of high-quality proteins in the human diet.
Discovery of highly potent triazoleantifungal agents with piperidine-oxadiazole side chains
Authors: He Xiaomeng , Jiang Yan , Zhang Yongqiang , Wu Shanchao , Dong Guoqiang , Liu Na , Liu Yang , Yao Jianzhong , Miao Zhenyuan , Wang Yan , Zhang Wannian , Sheng Chunquan
Published: December 2014

A series of novel triazole antifungal agents containing piperidine-oxadiazole side chains were designed and synthesized. Compound11bwas highly active againstCandida albicanswith a MIC value of 0.016 μg mL−1.
Ni(ii) ions cleave and inactivate human alpha-1 antitrypsin hydrolytically, implicating nickel exposure as a contributing factor in pathologies related to antitrypsin deficiency
Authors: Wezynfeld Nina Ewa , Bonna Arkadiusz , Bal Wojciech , Frączyk Tomasz
Published: December 2014

Ni(ii) ions cleave AAT hydrolytically, inactivating the protein.
Chiral assembly and plasmonic response of silver nanoparticles in a three-dimensional blue-phase nanostructure template
Authors: Shi Yang , Mo Jun , Wei Jie , Guo Jinbao
Published: December 2014

Three-dimensional chiral assembly of Ag-NPs in a BP polymer template was demonstrated where the hybrid architecture exhibited optical activity at Ag-NP plasmonic wavelengths as well as showed the ability to respond to the dielectric environment.
One-step sonoelectrochemical fabrication of gold nanoparticle/carbon nanosheet hybrids for efficient surface-enhanced Raman scattering
Authors: Zhang Kaige , Yao Su , Li Gongke , Hu Yuling
Published: December 2014

A simple, fast, reproducible and efficient one-step sonoelectrochemical method was successfully developed to prepare gold nanoparticle/carbon nanosheet (Au NP/CNS) hybrids, which show efficient surface-enhanced Raman scattering.
Photocontrol of ion permeation in lipid vesicles with amphiphilic dithienylethenes
Authors: Kandasamy Yamuna S. , Cai Jianxin , Beler Alisha , Sang M.-S. Jemeli , Andrews Patrick D. , Murphy R. Scott
Published: December 2014

Asymmetrical amphiphilic dithienylethenes have been prepared and photocontrol of ion permeation was observed in lipid vesicles.
Contrasting anion recognition behaviour exhibited by halogen and hydrogen bonding rotaxane hosts
Authors: Cornes Stuart P. , Davies Charles H. , Blyghton David , Sambrook Mark R. , Beer Paul D.
Published: December 2014

A [2]rotaxane anion host that switches selectivity from dihydrogen phosphate to the halides upon substituting a hydrogen bond donor group for a halogen bond donor group within the axle component is described.
Utilising polymers to understand diseases: advanced molecular imaging agents
Authors: Fuchs Adrian V. , Gemmell Anna C. , Thurecht Kristofer J.
Published: December 2014

This review describes how the highly tuneable size, shape and chemical functionality of polymeric molecular imaging agents provides a means to intimately probe the various mechanisms behind disease formation and behaviour.
Cellulose grafting by photoinduced controlled radical polymerisation
Authors: Larsson Emma , Pendergraph Samuel A. , Kaldéus Tahani , Malmström Eva , Carlmark Anna
Published: December 2014

Cellulose surfaces, in the form of filter paper, have been grafted utilizing UV-induced surface-initiated controlled radical polymerization of acrylates.
One-pot synthesis of magnetic molecularly imprinted microspheres by RAFT precipitation polymerization for the fast and selective removal of 17β-estradiol
Authors: Li Jinhua , Dong Ruichen , Wang Xiaoyan , Xiong Hua , Xu Shoufang , Shen Dazhong , Song Xingliang , Chen Lingxin
Published: December 2014

A one-pot synthesis strategy was developed to prepare magnetic molecularly imprinted microspheres for the selective recognition and fast removal of 17-beta-estradiol.
Novel integrated carbon particle based three dimensional anodes for the electrochemical degradation of reactive dyes
Authors: Misra Rohit , Neti Nageswara Nao , Dionysiou Dionysios D. , Tandekar Mahendra , Kanade Gajanan S.
Published: December 2014

Granular activated carbon (GAC) particles can be shaped into an integrated 3D-anode using PVDF binder and electro oxidation of reactive dyes in a three-dimensional flow-through carbon anode reactor (TDFCR) delivers a clean effluent free from carbon dust.
Temperature and CO2 responsive polyethylenimine for highly efficient carbon dioxide release
Authors: Kainz Johannes , Werz Patrick David Leonidas , Troll Carsten , Rieger Bernhard
Published: December 2014

Temperature and CO2 responsive behaviour and highly efficient carbon dioxide release was achieved via acylation of commercial available polyethylenimine.
Dielectric properties of Co(CO3)(H2O)2(C3H4N2)2 and [Co(C3H3N2)2]n
Authors: Świątek-Tran B. , Kołodziej (deceased) H. A. , Vogt A. , Tran V. H.
Published: December 2014

Dielectric relaxation phenomenon with non-Debye dynamics in Co(CO3)(H2O)2(C3H4N2)2 and [Co(C3H3N2)2]n, resembling the behaviour of ferroelectric relaxors is presumably connected with the charge carriers.
Fatty acids from edible sea hares: anti-inflammatory capacity in LPS-stimulated RAW 264.7 cells involves iNOS modulation
Authors: Pereira R. B. , Taveira M. , Valentão P. , Sousa C. , Andrade P. B.
Published: December 2014

The inclusion of marine organisms in the diet is gaining importance due to their richness in health beneficial nutrients.
One-step synthesis, characterization and catalytic performance of hierarchical Zn-ZSM-11 via facile ZnO routes
Authors: Yu Qingjun , Li Chunyi , Tang Xiaolong , Yi Honghong
Published: December 2014

Hierarchical Zn-ZSM-11 with an olive-shaped intergrowth morphology was synthesized via a novel and facile one-step hydrothermal method.
A convenient synthesis of 2-substituted benzofurans from salicylaldehydes
Authors: Reddy Swetha , Thadkapally Srinivas , Mamidyala Mounika , Nanubolu Jagadeesh Babu , Menon Rajeev S.
Published: December 2014

Base-mediated cyclocondensation of 2-hydroxybenzaldehydes with 3-bromo-1-(arylsulfonyl)propenes and 4-bromocrotonates afforded (E)-2-(2-sulfonylvinyl)benzofurans and (E)-2-benzofuranyl-3-acrylates, respectively.
Preparation and in vitro cell-biological performance of sodium alginate/nano-zinc silicate co-modified calcium silicate bioceramics
Authors: Xiong Kun , Zhang Jing , Shi Haishan , Liu Jingqun , Wu Huae , Li Haiyan , Ye Jiandong
Published: December 2014

We have prepared a (Zn, Na)-containing layer on the surface of calcium silicate bioceramics, which are spin-coated with sodium alginate and nano-zinc silicate.
3D hierarchical honeycomb structured MWCNTs coupled with CoMnAl–LDO: fabrication and application for ultrafast catalytic degradation of bisphenol A
Authors: Li Wen , Wu Pingxiao , Yang Shanshan , Zhu Yajie , Kang Chunxi , Tran Ly Tuong , Zeng Beilei
Published: December 2014

Schematic illustration for the synthesis of CNTs–LDH. (I): The surface modification of MWCNTs. (II): The adsorption of metal ions. (III): The formation of 2D CNTs–LDH nanosheets. (IV): The formation of 3D hierarchical honeycomb nano-structure.
Electrical characteristics of gallium–indium–zinc oxide thin-film transistor non-volatile memory with Sm2O3 and SmTiO3 charge trapping layers
Authors: Her Jim-Long , Chen Fa-Hsyang , Chen Ching-Hung , Pan Tung-Ming
Published: December 2014

In this study, we report the structural and electrical characteristics of high-κ Sm2O3 and SmTiO3 charge trapping layers on an indium–gallium–zinc oxide (IGZO) thin-film transistor (TFT) for non-volatile memory device applications.
Structure resembling effect of clay surface on photochemical properties of meso-phenyl or pyridyl-substituted monocationic antimony(v) porphyrin derivatives
Authors: Tsukamoto T. , Shimada T. , Takagi S.
Published: December 2014

The more hydrophobic antimony(v) porphyrin showed greater absorption transition probability increase and fluorescence quantum yield enhancement on the clay surface. These unique effects were discussed using the potential energy curves of porphyrin.
Titania synthesized through regulated mineralization of cellulose and its photocatalytic activity
Authors: Postnova Irina , Kozlova Ekaterina , Cherepanova Svetlana , Tsybulya Sergei , Rempel Andrey , Shchipunov Yury
Published: December 2014

Cellulose mineralization by titania is brought under control via restricted hydration of fibrils that provides precise localization of the fast hydration/condensation reactions proceeding in situ.
Bypassing the lack of reactivity of endo-substituted norbornenes with the catalytic rectification–insertion mechanism
Authors: Commarieu Basile , Claverie Jerome P.
Published: December 2014

The novel rectification–insertion mechanism for the polymerization of polar norbornenes: making alternating copolymers from a single monomer.
Stimuli-responsive metal–organic frameworks gated by pillar[5]arene supramolecular switches
Authors: Tan Li-Li , Li Haiwei , Qiu Yu-Chen , Chen Dai-Xiong , Wang Xin , Pan Rui-Yi , Wang Yan , Zhang Sean Xiao-An , Wang Bo , Yang Ying-Wei
Published: December 2014

Mechanized monodisperse nano metal–organic frameworks (NMOFs) gated by carboxylatopillar[5]arene (CP5) switches with bio-friendly pH-triggered release capabilities were constructed for the first time as a new stimuli-responsive theranostic hybrid platform.
Flexible free-standing graphene paper with interconnected porous structure for energy storage
Authors: Shu Kewei , Wang Caiyun , Li Sha , Zhao Chen , Yang Yang , Liu Huakun , Wallace Gordon
Published: December 2014

Flexible porous graphene paper was obtained via facile freeze drying method. It exhibits an excellent electrode performance in both the lithium battery and solid-state supercapacitor.
Polyaniline nanofiber/electrochemically reduced graphene oxide layer-by-layer electrodes for electrochemical energy storage
Authors: Jeon Ju-Won , Kwon Se Ra , Lutkenhaus Jodie L.
Published: December 2014

The layer-by-layer assembly of graphene oxide sheets and polyaniline nanofibers, followed by electrochemical reduction, results in highly porous electroactive electrodes for energy storage.
Strongly coupled thermal and chemical expansion in the perovskite oxide system Sr(Ti,Fe)O3−α
Authors: Perry Nicola H. , Kim Jae Jin , Bishop Sean R. , Tuller Harry L.
Published: December 2014

To evaluate stability in energy conversion devices, thermal and chemical expansion coefficients (CTE, CCE) of Sr(Ti,Fe)O3−α were measured and deconvoluted for the first time, revealing an oxygen stoichiometry-dependent CTE and temperature-dependent CCE.
A dense La(Sr)Fe(Mn)O3−δ nano-film anode for intermediate-temperature solid oxide fuel cells
Authors: Ju Young-Wan , Hyodo Junji , Inoishi Atsushi , Ida Shintaro , Ishihara Tatsumi
Published: December 2014

A dense La(Sr)Fe(Mn)O3−δ nano-film anode is fabricated between a La0.9Sr0.1Ga0.8Mg0.2O3−δ (LSGM) electrolyte film and a Ni–Fe metal substrate by pulsed laser deposition. The La(Sr)Fe(Mn)O3−δ nano-film improves power generation properties in solid oxide fuel cells with expanding anodic active surface area.
Intriguing differences in hydrogen adsorption in CPO-27 materials induced by metal substitution
Authors: Rosnes Mali H. , Opitz Martin , Frontzek Matthias , Lohstroh Wiebke , Embs Jan Peter , Georgiev Peter A. , Dietzel Pascal D. C.
Published: December 2014

We present a comparative study of hydrogen gas adsorption experiments on CPO-27–Cu and –Mn. The initial isosteric heat of adsorption in CPO-27–Cu is low for a material containing open metal sites and in contrast to the other members of the CPO-27 series, including the Mn compound.
Electrospun nanofibrous adsorbents for uranium extraction from seawater
Authors: Xie Siyuan , Liu Xiyan , Zhang Bowu , Ma Hongjuan , Ling Changjian , Yu Ming , Li Linfan , Li Jingye
Published: December 2014

A novel amidoxime (AO)-based adsorbent, integrating the high affinity of AO groups and size effect of nanomaterials in nanofibrous composite mats, has been prepared by a two-nozzle electrospinning process for uranium extraction from seawater.
Realizing room-temperature self-powered ethanol sensing of ZnO nanowire arrays by combining their piezoelectric, photoelectric and gas sensing characteristics
Authors: Wang Penglei , Fu Yongming , Yu Binwei , Zhao Yayu , Xing Lili , Xue Xinyu
Published: December 2014

Room-temperature self-powered ethanol sensing has been realized from ZnO nanowire arrays by combining their piezoelectric, photoelectric and gas sensing characteristics.
Superiority of the bi-phasic mixture of a tin-based alloy nanocomposite as the anode for lithium ion batteries
Authors: Li Xue , He Xinyi , Xu Yuefeng , Huang Ling , Li Juntao , Sun Shigang , Zhao Jinbao
Published: December 2014

The synthesis of multicomponent alloys with stable, homogeneous nanomaterial is an effective method to improve the cycling performance of tin-based anode materials.
A room-temperature method for coating a ZnS shell on semiconductor quantum dots
Authors: Jiang Peng , Zhu Chun-Nan , Zhu Dong-Liang , Zhang Zhi-Ling , Zhang Guo-Jun , Pang Dai-Wen
Published: December 2014

A room-temperature method based on phase transfer and reaction between Zn2+ and S2− in toluene for coating a ZnS shell on quantum dots.
Graphene quantum dots: versatile photoluminescence for energy, biomedical, and environmental applications
Authors: Wang Zhaofeng , Zeng Huidan , Sun Luyi
Published: December 2014

Graphene quantum dots have large surface area, high photostability, excellent biocompatibility and versatile photoluminescence, promising for various applications.
A gene signature for gold nanoparticle-exposed human cell lines
Authors: Liang Ruei-Yue , Tu Hsin-Fang , Tan Xiaotong , Yeh Yu-Shan , Chueh Pin Ju , Chuang Show-Mei
Published: December 2014

A unique four-gene signature for AuNP exposure was identified using the cDNA microarray and evaluated by qPCR and biological assays in mammalian cell lines.
Exacerbation of acute kidney injury by bone marrow stromal cells from rats with persistent renin–angiotensin system activation
Authors: Kankuri Esko , Mervaala Elina E. , Storvik Markus , Ahola Aija M.J. , Levijoki Jouko , Müller Dominik N. , Finckenberg Piet , Mervaala Eero M.
Published: December 2014

Hypertension and persistent activation of the renin–angiotensin system (RAS) are predisposing factors for the development of acute kidney injury (AKI). Although bone-marrow-derived stromal cells (BMSCs) have shown therapeutic promise in treatment of AKI, the impact of pathological RAS on BMSC functionality has remained unresolved. RAS and its local components in the bone marrow are involved in several key steps of cell maturation processes. This may also render the BMSC population vulnerable to alterations even in the early phases of RAS pathology. We isolated transgenic BMSCs (TG-BMSCs) from young end-organ-disease-free rats with increased RAS activation [human angiotensinogen/renin double transgenic rats (dTGRs)] that eventually develop hypertension and die of end-organ damage and kidney failure at 8 weeks of age. Control cells (SD-BMSCs) were isolated from wild-type Sprague–Dawley rats. Cell phenotype, mitochondrial reactive oxygen species (ROS) production and respiration were assessed, and gene expression profiling was carried out using microarrays. Cells’ therapeutic efficacy was evaluated in a rat model of acute ischaemia/reperfusion-induced AKI. Serum urea and creatinine were measured at 24 h and 48 h. Acute tubular damage was scored and immunohistochemistry was used for evaluation for markers of inflammation [monocyte chemoattractant protein (MCP-1), ED-1], and kidney injury [kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL)]. TG-BMSCs showed distinct mitochondrial morphology, decreased cell respiration and increased production of ROS. Gene expression profiling revealed a pronounced pro-inflammatory phenotype. In contrast with the therapeutic effect of SD-BMSCs, administration of TG-BMSCs in the AKI model resulted in exacerbation of kidney injury and high mortality. Our results demonstrate that early persistent RAS activation can dramatically compromise therapeutic potential of BMSCs by causing a shift into a pro-inflammatory phenotype with mitochondrial dysfunction.
Differential effects of chlorinated and oxidized phospholipids in vascular tissue: implications for neointima formation
Authors: Greig Fiona H. , Hutchison Lisa , Spickett Corinne M. , Kennedy Simon
Published: December 2014

The presence of inflammatory cells and MPO (myeloperoxidase) in the arterial wall after vascular injury could increase neointima formation by modification of phospholipids. The present study investigates how these phospholipids, in particular oxidized and chlorinated species, are altered within injured vessels and how they affect VSMC (vascular smooth muscle cell) remodelling processes. Vascular injury was induced in C57BL/6 mice and high fat-fed ApoE−/− (apolipoprotein E) mice by wire denudation and ligation of the left carotid artery (LCA). Neointimal and medial composition was assessed using immunohistochemistry and ESI–MS. Primary rabbit aortic SMCs (smooth muscle cells) were utilized to examine the effects of modified lipids on VSMC proliferation, viability and migration at a cellular level. Neointimal area, measured as intima-to-media ratio, was significantly larger in wire-injured ApoE−/− mice (3.62±0.49 compared with 0.83±0.25 in C57BL/6 mice, n=3) and there was increased oxidized low-density lipoprotein (oxLDL) infiltration and elevated plasma MPO levels. Relative increases in lysophosphatidylcholines and unsaturated phosphatidylcholines (PCs) were also observed in wire-injured ApoE−/− carotid arteries. Chlorinated lipids had no effect on VSMC proliferation, viability or migration whereas chronic incubation with oxidized phospholipids stimulated proliferation in the presence of fetal calf serum [154.8±14.2% of viable cells at 1 μM PGPC (1-palmitoyl-2-glutaroyl-sn-glycero-3-phosphocholine) compared with control, n=6]. In conclusion, ApoE−/− mice with an inflammatory phenotype develop more neointima in wire-injured arteries and accumulation of oxidized lipids in the vessel wall may propagate this effect.
The Commonwealth Bank of Australia – Strategizing from Outsourcing to the Cloud Part 1: Perennial Challenges Amidst Turbulent Technology
Authors: Willcocks Leslie , Reynolds Peter
Published: December 2014

This teaching case examines the challenges of using Information Technology (IT) outsourcing, adopting new technologies, undertaking business transformation, and evolving the IT function's structure, governance arrangements and capabilities – all in a dynamic business context. The Commonwealth Bank Australia has over the last 20 years experienced similar IT management dilemmas as countless organizations across the globe. The case foregrounds six perennial issues in IT management. First, what form of outsourcing is suitable at different stages of an organization's development, and how can that outsourcing be managed? The case here covers the challenges of single and multi-supplier outsourcing. Part 2 will focus on sourcing issues with cloud computing. Second, what are the key IT capabilities that must be retained within a large corporation? Part 2 will ask whether these capabilities change with cloud computing. Third, what are the mechanisms for developing, nurturing, maintaining, and evolving retained capabilities? Fourth, how should IT be governed in the face of changing business needs, new technologies, and changing organization structures? Fifth, Parts 1 and 2 of the case question the roles of the CEO, CIO, and business managers in leveraging IT performance for business value, the building of project and program management capabilities, and how to organize IT to support a business transformation program. Finally, the case raises the challenge for students of how an organization with its history and legacy in technology and sourcing partners can then move into even newer technologies – in this scenario cloud computing – the primary focus of Part 2 of the case. Overall, the two cases raise the fundamental challenge – what perennial management practices are effective, over time, in dealing with the challenges raised by changing technologies, and what new practices may be required, in contemporary dynamic business contexts.