Prediction of disease outcomes in patients with COVID-19 based on the EQ 5D 5L questionnaire
Authors:   Moscow Multidisciplinary Clinical Center “Kommunarka” of the Moscow Department of Health, Ayupova I. I. , Tyurin I.N. ,   Moscow Multidisciplinary Clinical Center “Kommunarka” of the Moscow Department of Health, Tyufilin D.S. ,   Federal Research Institute for Health Organization and Informatics of Ministry of Health of the Russian Federation, Kobyakova O.S. ,   Federal Research Institute for Health Organization and Informatics of the Ministry of Health of the Russian Federation, Tsaranov K.N. ,   Moscow Metropolitan Governance Yury Luzhkov University
Published: January 2023

In order to provide effective medical care to patients with COVID-19 in hospitals, the disease outcome prognosis is of considerable importance. The authors of the study suggested a relationship between health-related quality of life indicators and the outcomes of the disease of patients hospitalized because of COVID-19. P u r p o s e . Retrospective study of the relationship between health-related quality of life in patients with COVID-19 on the first day of hospitalization with the outcomes of the disease in a hospital and at the stages of rehabilitation up to 180 days following the discharge to predict outcomes at the early stages of the disease. M a t e r i a l s a n d m e t h o d s . The study was conducted at the “Kommunarka” Moscow Multidisciplinary Clinical Center of the Moscow City Health Department from March 2021 to April 2022. Data collection was carried out using a paper-and-pencil Russian version of the EQ-5D-5L questionnaire (Tracking Number: 41183), on the first day of admission of patients to the hospital. Additional patient data was extracted from electronic health records. Two types of EQ-5D-5L questionnaire results were evaluated: Index EQ and the Visual Analog scale (VAS) EQ. All calculations of the regression model were carried out using the R 4.2.1 language in the RStudio 2022.02.3 Build 492 software environment. F i n d i n g s . In the obtained logistic regression model, the extremely high statistical significance of the variable “Index EQ” (p<0.01) was demonstrated, the greater the value of the variable “Index EQ” is, the less the probability of a fatal outcome is. At the same time, there is no statistically significant relationship between the variable VAS EQ under study and the probability of a fatal outcome. C o n c l u s i o n s . An extremely significant relationship between the calculated health-related quality of life index, Index EQ, and outcomes of COVID-19 when patients were admitted to the hospital was revealed, which makes it possible to use it as a predictor of disease outcomes at early stages. No significant relationship between the VAS EQ and the outcomes of the disease in patients with COVID-19 on the first day of hospitalization was revealed, which makes it impossible to use it as a predictor of disease outcomes at the early stages. Application of the health-related quality of life index, Index EQ can be used to make medical decisions in order to early predict tactics of patient management in hospital treatment and rehabilitation.