bluuebunny/crossref_metadata_2025 huggingface dataset:
Genesis of the Heroin-Induced Addictive Process: Articulation Between Psychodynamic and Neurobiological Theories
Authors: Scarna Hélène
Published: December 2020

Psychotherapeutic consultations of drug addict's patients in a Care, Support and Prevention Center in Addictology led us to propose several hypotheses on the genesis of addiction and its articulation with currently available neurobiological data. This care center dispenses both pharmacological maintenance medications for heroin dependence, such as methadone or buprenorphine, and psychological support. Our first hypothesis posits that the addictive process is driven by the narcissistic vulnerability of these patients, its neurobiological foundations being mainly mediated by the activation of endogenous opioid systems. Drug use/abuse could be a way to make arise the “True Self,” therefore overcoming the defensive system's set up to protect oneself from early traumas. The neurobiological impact of traumas is also developed and articulated with psychodynamic concepts, particularly those of Winnicott. Additionally, functions of addiction such as defensive, anti-depressant roles and emotional regulation are discussed in relationship with their currently known neuroscientific bases. Although the experience in the psychodynamic clinic is at a level of complexity much higher than what is currently accessible to the neurosciences, most of the research in this domain stays in line with our psychological understanding of the addictive process. Finally, we outline some critically sensitive points regarding the therapeutic support.
The National Health and Resilience in Veterans Study: A Narrative Review and Future Directions
Authors: Fogle Brienna M. , Tsai Jack , Mota Natalie , Harpaz-Rotem Ilan , Krystal John H. , Southwick Steven M. , Pietrzak Robert H.
Published: December 2020

United States (U.S.) veterans are substantially older than their non-veteran counterparts. However, nationally representative, population-based data on the unique health needs of this population are lacking. Such data are critical to informing the design of large-scale outreach initiatives, and to ensure the effectiveness of service care delivery both within and outside of the Veterans Affairs healthcare system. The National Health and Resilience in Veterans Study (NHRVS) is a contemporary, nationally representative, prospective study of two independent cohorts (n= 3,157 andn= 1,484) of U.S. veterans, which is examining longitudinal changes, and key risk and protective factors for several health outcomes. In this narrative review, we summarize the main findings of all NHRVS studies (n= 82) published as of June 2020, and discuss the clinical implications, limitations, and future directions of this study. Review of these articles was organized into six major topic areas: post-traumatic stress disorder, suicidality, aging, resilience and post-traumatic growth, special topics relevant to veterans, and genetics and epigenetics. Collectively, results of these studies suggest that while a significant minority of veterans screen positive for mental disorders, the majority are psychologically resilient. They further suggest that prevention and treatment efforts designed to promote protective psychosocial characteristics (i.e., resilience, gratitude, purpose in life), and social connectedness (i.e., secure attachment, community integration, social engagement) help mitigate risk for mental disorders, and promote psychological resilience and post-traumatic growth in this population.
Ultra-Brief Crisis IPT-A Based Intervention for Suicidal Children and Adolescents (IPT-A-SCI) Pilot Study Results
Authors: Haruvi Catalan Liat , Levis Frenk Mira , Adini Spigelman Ella , Engelberg Yair , Barzilay Shira , Mufson Laura , Apter Alan , Benaroya Milshtein Noa , Fennig Silvana , Klomek Anat Brunstein
Published: December 2020

In recent years, suicidal behaviors have shown substantial increase worldwide. This trend is also prominent in Israel and has led to a dramatic increase in mental health treatment demand resulting in long wait times and low treatment acceptance rate. To address the critical need in crisis intervention for children and adolescents at suicidal risk we developed an ultra-brief acute crisis intervention, based on Interpersonal Psychotherapy (IPT). IPT is an evidence-based intervention for various psychopathologies among different age groups. The current adaptation of IPT-A is comprised of five weekly sessions, followed by monthly follow-up caring email contacts to the patients and their parents, over a period of 3 months. This paper aims to review the theoretical foundation of this intervention, describe the research design, and present preliminary results of a pilot study. Preliminary Results from our samples of 26 adolescents indicate meaningful trends for both the suicidal ideation (SIQ) and depression (MFQ) outcome measures. Significant interaction was found concerning suicidal ideation but not for depression. Main limitations include small sample size and stratified controls. The treatment appears to be safe, feasible and acceptable and initial results show promising trends to support further study of the approach.
Sociodemographic and Clinical Predictors of the Length of Psychiatric Inpatient Stay of Immigrants in Switzerland
Authors: Frizi Renée , Lay Barbara , Seifritz Erich , Kawohl Wolfram , Habermeyer Benedikt , Roser Patrik
Published: December 2020

Immigrants with mental disorders have consistently been reported to spend shorter time in the psychiatric hospital compared to native patients. The aim of this study was to identify sociodemographic, clinical and migration-related predictors of a shorter length of psychiatric inpatient stay among immigrants in Switzerland. All patients of a foreign nationality admitted for inpatient treatment in the year 2016 (N = 279) were included in this study. The sample characteristics were drawn from the register of the psychiatric hospital. Within this sample, self-harm and substance use predicted a shorter inpatient treatment episode whereas disturbances of general psychosocial functioning were a predictor of a longer length of stay. As similar results were also reported for non-immigrant patients, the impact of these specific behavioral and social problems on the length of inpatient stay does not appear to be migrant-specific. Moreover, a country of origin outside Europe was a strong predictor of shorter length of stay pointing to inequalities of inpatient psychiatric treatment within the group of immigrants. Therefore, the cultural background and migrant history of immigrants in psychiatry need stronger consideration in order to eliminate disadvantages in mental health care.
Supporting Female Survivors of Gender-Based Violence Experiencing Homelessness: Outcomes of a Health Promotion Psychoeducation Group Intervention
Authors: Bani-Fatemi Ali , Malta Monica , Noble Amanda , Wang Wei , Rajakulendran Thanara , Kahan Deborah , Stergiopoulos Vicky
Published: December 2020

Homelessness is an important risk factor for gender-based violence (GBV), particularly among youth, and disproportionally affects women and girls. Survivors of GBV experience enduring and severe physical, psychological, and sexual health problems. Although key elements in service delivery for survivors of GBV have been identified, little is known about outcomes of community-based programs aiming to assist homeless and unstably housed youth experiencing GBV. This longitudinal study aimed to quantitatively evaluate changes in mental health and well-being outcomes in female identified youth experiencing GBV and homelessness, 12 months after enrolment in a community-based, trauma-informed, brief group psychoeducation intervention. Standardized survey measures were administered at baseline, 6 and 12 months for 70 participants, recruited between February 2017 and April 2019, assessing quality of life, psychological distress, traumatic symptoms, substance use, resilience, victimization, and sense of mastery. Linear mixed models were used to examine longitudinal changes in quality of life as well as secondary outcomes among study participants. After 12 months, quality of life increased significantly among participants (p = 0.009), and the 12-month victimization score was significantly decreased relative to baseline (p = 0.05). Changes in other outcomes were not statistically significant. Findings suggest that community-based brief group psychoeducation interventions may be a promising approach to improving outcomes for this disadvantaged population.
FMG- and RNN-Based Estimation of Motor Intention of Upper-Limb Motion in Human-Robot Collaboration
Authors: Anvaripour Mohammad , Khoshnam Mahta , Menon Carlo , Saif Mehrdad
Published: December 2020

Research on human-robot interactions has been driven by the increasing employment of robotic manipulators in manufacturing and production. Toward developing more effective human-robot collaboration during shared tasks, this paper proposes an interaction scheme by employing machine learning algorithms to interpret biosignals acquired from the human user and accordingly planning the robot reaction. More specifically, a force myography (FMG) band was wrapped around the user's forearm and was used to collect information about muscle contractions during a set of collaborative tasks between the user and an industrial robot. A recurrent neural network model was trained to estimate the user's hand movement pattern based on the collected FMG data to determine whether the performed motion was random or intended as part of the predefined collaborative tasks. Experimental evaluation during two practical collaboration scenarios demonstrated that the trained model could successfully estimate the category of hand motion, i.e., intended or random, such that the robot either assisted with performing the task or changed its course of action to avoid collision. Furthermore, proximity sensors were mounted on the robotic arm to investigate if monitoring the distance between the user and the robot had an effect on the outcome of the collaborative effort. While further investigation is required to rigorously establish the safety of the human worker, this study demonstrates the potential of FMG-based wearable technologies to enhance human-robot collaboration in industrial settings.
Large Group Housing Systems in Fattening Bulls—Comparison of Behavior and Performance
Authors: Schneider Laura , Volkmann Nina , Spindler Birgit , Kemper Nicole
Published: December 2020

According to international housing recommendations, fattening bulls should not be housed in groups of more than 12–20 animals. However, there are no scientific studies supporting these recommendations as most studies on fattening cattle refer to smaller groups. Therefore, the aim of this study was to analyze and compare behavior and performance of 187 fattening bulls housed in different group sizes of 16, 22, and 33 animals. Behavioral observations were performed during three observation periods at an average age of 8.5, 13, and 17 months. Furthermore, body condition, health status and carcass weights were analyzed. Effects of increasing group size were observed regarding more synchronized lying behavior, longer lying durations and more undisturbed feeding and lying behavior. Interindividual variations in lying and feeding as well as mean and maximum percentages of animals participating simultaneously in interactions did not increase with group size. Health and growth performance were satisfactory in all group sizes. Therefore, the results of this study do not provide scientific evidence for the common argument that increasing group size leads to increased aggression. Furthermore, these findings indicate large group systems to be suitable for the housing of fattening cattle and to contribute to increasing animal welfare. Consequently, current recommendations should be revised.
Association Between Tail-Biting and Intestinal Microbiota Composition in Pigs
Authors: Rabhi Nassima , Thibodeau Alexandre , Côté Jean-Charles , Devillers Nicolas , Laplante Benoit , Fravalo Philippe , Larivière-Gauthier Guillaume , Thériault William P. , Faucitano Luigi , Beauchamp Guy , Quessy Sylvain
Published: December 2020

Tail-biting (TB) in pigs is a serious behavioral disorder. It is an important challenge in swine production as it impacts animal welfare and health and the economics and safety of the pork meat supply chain. To prevent TB, approaches including enrichment material and tail docking are proposed but none are optimal. Nutrition appears to be an important factor in TB behavior, perhaps by modulating the intestinal microbiota (IM). Our aim was to assess the association between TB behavior and IM in pigs through comparisons of IM in groups of biter, bitten and non-biter/non-bitten pigs. Each group composed of 12 pigs was formed at the beginning of the growing/finishing phase based on a target behavior analysis centered on TB behavior for the biter group and a score of damages caused to the tail for the bitten group. Blood and fecal samples were collected from each pig during a TB episode, at time 0, t0, and when the TB episode was considered finished, 4 weeks later, at time 1, t1. Serum cortisol level was determined by ELISA and used as an indicator of stress. The pig's fecal microbiota was analyzed from DNA extracted from freshly collected fecal matter using amplicon sequencing of the V4 hypervariable region of the 16S rRNA gene. Serum cortisol levels were significantly higher in either the biter or bitten pig groups compared to the negative control group (p = 0.02 and p = 0.01, respectively). The microbiota alpha-diversity was not significantly different between all groups, biter, bitten and negative control. Analyses of beta-diversity, however, revealed a significant difference between either the biter or the bitten group in comparison to the non-biter/non-bitten negative control group in terms of structure and composition of the microbiota. Lactobacillus were significantly more abundant in the negative control group compared to the two other groups (p = 0.001). No significant difference was revealed between the biter and bitten groups. Quantitative real-time PCR (qPCR) confirmed that lactobacilli were more abundant in the negative control group. Our study indicates that TB behavior is associated with the IM composition in pigs.
The Mycotoxin Deoxynivalenol (DON) Promotes Campylobacter jejuni Multiplication in the Intestine of Broiler Chickens With Consequences on Bacterial Translocation and Gut Integrity
Authors: Ruhnau Daniel , Hess Claudia , Grenier Bertrand , Doupovec Barbara , Schatzmayr Dian , Hess Michael , Awad Wageha A.
Published: December 2020

Deoxynivalenol (DON) is one of the major health concern in poultry production as it targets epithelial cells of the gastrointestinal tract and contributes to the loss of the epithelial barrier function. It is well-documented that DON severely compromises various important intestinal functions in coincidence with aggravated clinical symptoms in livestock. In addition, a prolonged persistence of intestinal pathogens (e.g., Salmonella, Clostridium) in the gut has also been reported in pigs and chickens, respectively. Similar to DON, recent studies demonstrated that an experimental Campylobacter infection has severe consequences on gut health. Through experimental infection, it was found that Campylobacter (C.) jejuni negatively affects the integrity of the intestine and promotes the translocation of bacteria from the gut to inner organs. So far, no data are available investigating the simultaneous exposure of DON and C. jejuni in broilers albeit both are widely distributed. Thus, the aim of the present study was to explore the interaction between DON and C. jejuni which is of a significant public and animal health concern as it may affect the prevalence and the ability to control this pathogen. Following oral infection of birds at 14 days of age with C. jejuni NCTC 12744, we show that the co-exposure to DON and C. jejuni has a considerable consequence on C. jejuni loads in chicken gut as well as on gut permeability of the birds. A reduced growth performance was found for DON and/or C. jejuni exposed birds. Furthermore, it was found that the co-exposure of DON and C. jejuni aggravated the negative effect on paracellular permeability of the intestine already noticed for the bacteria or the mycotoxin alone by the Ussing chamber technique at certain times or intestinal segments. Furthermore, the increased paracellular permeability promotes the translocation of C. jejuni and E. coli to inner organs, namely liver and spleen. Interestingly, C. jejuni loads in the intestine were higher in DON-fed groups indicating a supportive growth effect of the mycotoxin. The actual study demonstrates that co-exposure of broiler chickens to DON and C. jejuni has not only considerable consequences on gut integrity but also on bacterial balance. These findings indicate that the co-exposure of broiler chickens to DON and C. jejuni could have a significant impact on gut health and bacteria translocation leading to an increased risk for public health.
Floor Substrate Preferences of Chickens: A Meta-Analysis
Authors: Monckton Valerie , Ellis Jennifer L. , Harlander-Matauschek Alexandra
Published: December 2020

Environmental enrichment promotes sensory and motor stimulation for species-typical behaviors, which in turn enhance animal well-being. For farmed Galliformes, housing systems often limit enrichment to bedding and litter, that simultaneously act as material for dustbathing and foraging. Therefore, this meta-analysis sought to systematically review and synthesize the substrate preference test literature for Galliformes. Data based on the following four welfare-related behaviors were extracted for analysis: (1) dustbathing, (2) foraging, (3) pecking, and (4) time spent on a given substrate. Literature searches in CAB Direct, Web of Science, and Google Scholar yielded 239 articles, and hand searching yielded an additional five articles. Ten publications that used different chicken strains as test subjects, met the criteria to be included in the systematic review. The effects of bedding type, the number of days birds had access to tested substrates, enclosure area, and substrate area, on the examined behaviors were determined. We found that birds preferred dustbathing in sand and peat moss more than on any other substrates. The bedding type, size of the enclosure, and size of the substrate area affected the amount of time that birds spent on the tested substrates. When provided the choice between bedding materials, birds spent more time on sand or peat moss than on any other substrate or on no substrate. Notably, most studies did not report relevant physical or chemical characteristics of substrate that may influence birds' preferences, such as grain size, moisture content and the level of soiling. Focusing future studies on identifying substrate characteristics that influence preferences can lead to the discovery of new, practical, enriching beddings that can be easily implemented in housing systems for Galliformes.
Green Food Development in China: Experiences and Challenges
Authors: Xu Jiuliang , Zhang Zhihua , Zhang Xian , Ishfaq Muhammad , Zhong Jiahui , Li Wei , Zhang Fusuo , Li Xuexian
Published: December 2020

China feeds approximately 22% of the global population with only 7% of the global arable land because of its surprising success in intensive agriculture. This outstanding achievement is partially overshadowed by agriculture-related large-scale environmental pollution across the nation. To ensure nutrition security and environmental sustainability, China proposed the Green Food Strategy in the 1990s and set up a specialized management agency, the China Green Food Development Center, with a monitoring network for policy and standard creation, brand authorization, and product inspection. Following these 140 environmental and operational standards, 15,984 green food companies provided 36,345 kinds of products in 2019. The cultivation area and annual domestic sales (CNY 465.7 billion) of green food accounted for 8.2% of the total farmland area and 9.7% of the gross domestic product (GDP) from agriculture in China. Herein, we systemically reviewed the regulation, standards, and authorization system of green food and its current advances in China, and then outlined its environmental benefits, challenges, and probable strategies for future optimization and upscaling. The rapid development of the green food industry in China suggests an applicable triple-win strategy for protecting the environment, promoting agroeconomic development, and improving human nutrition and health in other developing countries or regions.
Influence of Spray Technology and Application Rate on Leaf Deposit and Ground Losses in Mountain Viticulture
Authors: Michael Costas , Gil Emilio , Gallart Montserrat , Stavrinides Menelaos C.
Published: December 2020

Leaf deposit and ground losses generated from spray application in mountain viticulture were evaluated. Four treatments were examined: A spray gun (1000 L ha−1, High-Volume Sprayer—HVS), a motorized knapsack sprayer (200 L ha−1, Low Volume Sprayer—LVS), and a conventional orchard mist blower calibrated at 500 L ha−1 (OS500) or 250 L ha−1 (OS250). The four treatments were assessed using the same tank concentration of tracer in two training systems: a trellis and a goblet. Sprayer treatment, vine side, and vine height significantly affected leaf deposit (p < 0.05). The absolute amount of leaf deposit increased with application volume, but when the amount of deposit was standardized to 1 kg ha−1, LVS resulted in the highest deposit, followed by HVS, OS250, and OS500. Deposition for the goblet system was ca. half that for the trellised vineyard. Ground losses standardized to 1 kg of tracer ha−1 were twice as high for HVS than for LVS, and four times as high for HVS than for OS250 and OS500, in both training systems. The current work suggests that low volume applications in vineyards are a viable and more environmentally friendly alternative than high volume treatments.
Impacts of Milking and Housing Environment on Milk Microbiota
Authors: Du Bingyao , Meng Lu , Liu Huimin , Zheng Nan , Zhang Yangdong , Guo Xiaodong , Zhao Shengguo , Li Fadi , Wang Jiaqi
Published: December 2020

The aim of the present study was to determine the effects of farming environments on microbiota in raw milk and to assess the relationship among microbes by 16S rRNA sequencing methods. Samples of raw milk, cow trough water, teat dip cup, teat, teat liner, dairy hall air, cowshed air, feces, feed, and bedding from two farms were collected. The two highest abundant bacterial groups of Moraxellaceae and Staphylococcaceae were found in milk and teat liner samples, respectively, at Zhengzhou farm, Henan Province. Moreover, the two highest abundant bacterial groups of Enterobacteriaceae and Moraxellaceae were found in milk and teat dip cup samples, respectively, at Qiqihar farm, Heilongjiang Province. Source Tracker analysis revealed that the teat liner and teat dip cup were the most important contributors of microbes in milk samples at Zhengzhou farm and Qiqihar farm, respectively, which could be attributed to the management level of the farm. Therefore, disinfection and cleaning procedures should be developed to improve the quality of raw milk.
Effects of Oat Hay Content in Diets on Nutrient Metabolism and the Rumen Microflora in Sheep
Authors: An Xuejiao , Zhang Lingyun , Luo Jing , Zhao Shengguo , Jiao Ting
Published: December 2020

Oats have the characteristics of drought tolerance, cold resistance, strong adaptability, high forage yield, and high nutritional value. However, there are few reports on the most appropriate amount of oat hay in ruminant diets, the digestion and metabolism of ruminants, and the rumen microflora. To study the effects of oat hay content in diets on nutrient digestion and metabolism and the rumen microflora in sheep, 9 German Merino and Mongolian crossbred rams of similar body condition and weight with permanent fistulas were selected. The 3 × 3 Latin square design was used to randomly divide the rams into 3 groups, with 3 animals in each group. The three groups were fed different kinds of roughage: whole-plant corn silage only (corn silage group, CSG), oat hay mixed with whole-plant corn silage (1:1) (mixed group, MG), and oat hay only (oat hay group, OHG). The nutrient digestion and metabolism of each group were measured, and the pH and rumen microflora were examined after feeding for different durations. Dynamic changes in microbial communities were detected. The nutrient digestion and metabolism results showed that, with an increase in the content of oat hay in the diet, the intake and apparent digestibility of dry matter (DM) and organic matter (OM) showed an increasing trend, and the intake, digestion, and stability of acid detergent fiber (ADF) and neutral detergent fiber (NDF) increased in the OHG. The apparent digestibility, dietary nitrogen, deposited nitrogen, and nitrogen retention rate in this group were significantly higher than those in the CSG (p < 0.05). The rumen pH and sequencing results showed that the rumen fluid pH of the CSG was significantly lower than that of the OHG at 1 and 5 h (p < 0.05). The main microbial in the rumen of the three groups of sheep were Bacteroides, Sclerotium, and Proteus. The dominant taxon in the CSG was Prevotella, followed by Vibrio syringae, and the dominant taxon in the MG and OHG was Prevotella, followed by Rikenellaceae. Redundancy analysis showed that ADF and NDF in the feed had an effect on the abundance of Fibrobacteres, Ruminococcaceae, and Prevotella. Our findings indicate that the use of oat hay roughage in the diet significantly improves the apparent digestibility of NDF and ADF and helps maintain the stable state of the sheep’s rumen internal environment and the growth of rumen microorganisms.
Sexual Maturity Promotes Yolk Precursor Synthesis and Follicle Development in Hens via Liver-Blood-Ovary Signal Axis
Authors: Cui Zhifu , Amevor Felix Kwame , Feng Qian , Kang Xincheng , Song Weizhen , Zhu Qing , Wang Yan , Li Diyan , Zhao Xiaoling
Published: December 2020

Several reproductive hormones were reported to be involved in regulating egg yolk precursor synthesis in chickens; however, the mechanism that shows how the liver-blood-ovary signal axis works in relation to age changes has not been reported yet. Therefore, in this study, we observe the morphology and histology of the liver and ovary and determine the serum biochemical parameters and the expression abundance of the critical genes from d90 to 153. Results show that the body weight and liver weight were significantly increased from d132, while the ovary weight increased from d139. Aside from the increase in weight, other distinct changes such as the liver color and an increased deposition of large amounts of yolk precursors into the ovarian follicles were observed. On d139, we observed small fatty vacuoles in the hepatocytes. The results of serum biochemical parameters showed a significant increase in the estradiol (E2) level, first on d125, and then it reached its peak on d132. Meanwhile, the levels of follicle-stimulating hormone (FSH) increased initially and then remained at a high level from d146 to d153, while the levels of luteinizing hormone (LH) increased significantly on d132 and reached the top level on d153. Moreover, the levels of lecithin (LEC), vitellogenin (VTG), very low density lipoprotein y (VLDLy), triglyceride (TG), and total cholesterol (TC) were significantly increased at d125 and were close from d146 to d153. The mRNA and protein expression of estrogen receptor-alpha (ER-α) and E2 levels in the liver and serum, respectively, showed similar changes. Moreover, with reference to an increase in serum E2 level, the mRNA expression of genes related to yolk precursor synthesis (very low density apolipoprotein-II, ApoVLDL-II) and vitellogenin-II (VTG-II), lipogenesis (fatty acid synthase, FAS), and lipid transport (microsomal triglyceride transport protein, MTTP) in the liver showed up-regulation. These results suggest that the correlation between liver-blood-ovary alliances regulate the transport and exchange of synthetic substances to ensure synchronous development and functional coordination between the liver and ovary. We also found that E2 is an activator that is regulated by FSH, which induces histological and functional changes in the hepatocytes through the ER-α pathway.
Divergence in Gut Bacterial Community Structure between Male and Female Stag Beetles Odontolabis fallaciosa (Coleoptera, Lucanidae)
Authors: Wan Xia , Jiang Yu , Cao Yuyan , Sun Binghua , Xiang Xingjia
Published: December 2020

Odontolabis fallaciosa (Coleoptera: Lucanidae) is a giant and popular stag beetle with striking sexual dimorphism and male trimorphism. However, little is known about their intestinal microbiota, which might play an indispensable role in shaping the health of their hosts. The aim of this study was to investigate the intestinal bacterial community structure between the two sexes and among three male morphs of O. fallaciosa from China using high-throughput sequencing (Illumina MiSeq). The gut bacterial community structure was significantly different between males and females, suggesting that sex appeared to be the crucial factor shaping the intestinal bacterial community. Females had higher bacterial alpha-diversity than males. There was little difference in gut bacterial community structure among the three male morphs. However, compared to medium and small males, large individuals were associated with the higher relative abundance of Firmicutes and Firmicutes/Bacteroides (F/B) ratio, which might contribute to nutritional efficiency. Overall, these results might help to further our understanding of beetle–bacterial interactions of O. fallaciosa between the two sexes, and among the three male morphs.
Capsaicin, a Powerful •OH-Inactivating Ligand
Authors: Pérez-González Adriana , Prejanò Mario , Russo Nino , Marino Tiziana , Galano Annia
Published: December 2020

Oxidative conditions are frequently enhanced by the presence of redox metal ions. In this study, the role of capsaicin (8-methyl-N-vanillyl-6-nonenamide, CAP) in copper-induced oxidative stress was investigated using density functional theory simulations. It was found that CAP has the capability to chelate Cu(II), leading to complexes that are harder to reduce than free Cu(II). CAP fully turns off the Cu(II) reduction by Asc−, and slows down the reduction in this cation by O2•−. Therefore, CAP is proposed as an •OH-inactivating ligand by impeding the reduction in metal ions (OIL-1), hindering the production of •OH via Fenton-like reactions, at physiological pH. CAP is also predicted to be an excellent antioxidant as a scavenger of •OH, yielded through Fenton-like reactions (OIL-2). The reactions between CAP-Cu(II) chelates and •OH were estimated to be diffusion-limited. Thus, these chelates are capable of deactivating this dangerous radical immediately after being formed by Fenton-like reactions.
Looking Back at the Early Stages of Redox Biology
Authors: Flohé Leopold
Published: December 2020

The beginnings of redox biology are recalled with special emphasis on formation, metabolism and function of reactive oxygen and nitrogen species in mammalian systems. The review covers the early history of heme peroxidases and the metabolism of hydrogen peroxide, the discovery of selenium as integral part of glutathione peroxidases, which expanded the scope of the field to other hydroperoxides including lipid hydroperoxides, the discovery of superoxide dismutases and superoxide radicals in biological systems and their role in host defense, tissue damage, metabolic regulation and signaling, the identification of the endothelial-derived relaxing factor as the nitrogen monoxide radical (more commonly named nitric oxide) and its physiological and pathological implications. The article highlights the perception of hydrogen peroxide and other hydroperoxides as signaling molecules, which marks the beginning of the flourishing fields of redox regulation and redox signaling. Final comments describe the development of the redox language. In the 18th and 19th century, it was highly individualized and hard to translate into modern terminology. In the 20th century, the redox language co-developed with the chemical terminology and became clearer. More recently, the introduction and inflationary use of poorly defined terms has unfortunately impaired the understanding of redox events in biological systems.
Impact of Alkali Ions Codoping on Magnetic Properties of La0.9A0.1Mn0.9Co0.1O3 (A: Li, K, Na) Powders and Ceramics
Authors: Głuchowski Paweł , Nikonkov Ruslan , Tomala Robert , Stręk Wiesław , Shulha Tatsiana , Serdechnova Maria , Zarkov Aleksej , Murauskas Tomas , Pakalaniškis Andrius , Skaudžius Ramūnas , Kareiva Aivaras , Kholkin Andrei , Bushinsky Maxim , Latushka Sergei , Karpinsky Dmitry
Published: December 2020

The aim of the work was to check how the introduction of alkali and cobalt ions into a manganese structure can affect the structural disorder and, in consequence, lead to the changes (improvements) of magnetic properties. The high-pressure sintering technique was applied to check if the external factor can modify the magnetization of manganites. Nanocrystalline La0.9A0.1Mn0.9Co0.1O3 (where A is Li, K, Na) powders were synthesized by the combustion technique. The respective powders were used for nanoceramics preparation by the high-pressure sintering technique. The structure and morphology of the compounds were studied by X-ray powder diffraction, scanning electron microscopy and energy-dispersive X-ray spectroscopy. Magnetization studies for all compounds were performed in order to check the changes induced by either codoping or the sintering pressure. It was found that the type of the dopant ion and sintering pressure produced significant changes to the magnetic properties of the studied compounds. Alkali ions lead to the stabilization of Co ions in the +2 oxidation state and the formation of positive exchange interactions Mn3+–Mn4+ and Co2+–Mn4+ and the subsequent increase in remanent magnetization. High sintering pressure leads to a decrease in grain size and reduction of long-range ferromagnetic order and lower magnetization.
Experimental and Comparative Study of Rotor Vibrations of Permanent Magnet Machines with Two Different Fractional Pole/Slot Combinations
Authors: Bang Tae-Kyoung , Shin Kyung-Hun , Lee Jeong-In , Lee Hoon-Ki , Cho Han-Wook , Choi Jang-Young
Published: December 2020

This study deals with the noise, vibration, and harshness (NVH) characteristic analysis of permanent magnet synchronous motors (PMSMs) for electrical machines, such as electrically driven tools that are used in industries. An improved NVH design is needed for application to industrial tools. In general, the electromagnetic NVH characteristics of PMSMs are classified into electromagnetic excitation sources, such as total harmonic distortion of EMF, torque pulsation, magnetic pull force, and unbalanced magnetic force (UMF). This study compares the vibration and noise generated by fractional pole/slot combinations. In PMSMs with fractional pole/slot combinations, UMF is an important NVH source. PMSMs generate UMF because of armature reaction fields based on the pole/slot combinations and harmonics of magnetic flux density. UMF was derived using the finite element method, and the rotor vibration analysis was performed using electromagnetic mechanical coupling analysis. The analysis results and the effect of electromagnetic excitation characteristics on the rotor vibration of the PMSMs were compared and analyzed.
An Approach of Automatic SPARQL Generation for BIM Data Extraction
Authors: Guo Dongming , Onstein Erling , Rosa Angela Daniela La
Published: December 2020

Generally, building information modelling (BIM) models contain multiple dimensions of building information, including building design data, construction information, and maintenance-related contents, which are related with different engineering stakeholders. Efficient extraction of BIM data is a necessary and vital step for various data analyses and applications, especially in large-scale BIM projects. In order to extract BIM data, multiple query languages have been developed. However, the use of these query languages for data extraction usually requires that engineers have good programming skills, flexibly master query language(s), and fully understand the Industry Foundation Classes (IFC) express schema or the ontology expression of the IFC schema (ifcOWL). These limitations have virtually increased the difficulties of using query language(s) and raised the requirements on engineers’ essential knowledge reserves in data extraction. In this paper, we develop a simple method for automatic SPARQL (SPARQL Protocol and RDF Query Language) query generation to implement effective data extraction. Based on the users’ data requirements, we match users’ requirements with ifcOWL ontology concepts or instances, search the connected relationships among query keywords based on semantic BIM data, and generate the user-desired SPARQL query. We demonstrate through several case studies that our approach is effective and the generated SPARQL queries are accurate.
Edge Effect Analysis and Edge Defect Detection of Titanium Alloy Based on Eddy Current Testing
Authors: Xie Yuedong , Li Jiyao , Tao Yang , Wang Shupei , Yin Wuliang , Xu Lijun
Published: December 2020

Titanium alloy is widely used in the area of aerospace and aviation due to its excellent properties. Eddy current testing (ECT) is among the most extensively used non-destructive techniques for titanium alloy material inspection. However, most previous research has focused on inspecting defects far from the edge of the material. It is a challenging task for edge crack detection because of edge effect. This study aims to investigate the influences of sensor parameters on edge effect and defect detection capability, and in the meantime, optimize sensor parameters to improve the capability of edge defect detection. The simulation method for edge effect evaluation is proposed including the 2k factorial design used for factor screening, and the regression model is fitted and validated for sensor design and optimization for edge defect detection. A simulation scheme is designed to investigate the defect detection capability. An approach comprehensively analyzing the influence of coil parameters on edge effect and defect detection capability is applied to determine the optimal coil parameters for edge defect detection.
Two-Dimensional Symmetric Box Delivery Motion Prediction and Validation: Subtask-Based Optimization Method
Authors: Xiang Yujiang , Tahmid Shadman , Owens Paul , Yang James
Published: December 2020

Box delivery is a complicated manual material handling task which needs to consider the box weight, delivering speed, stability, and location. This paper presents a subtask-based inverse dynamic optimization formulation for determining the two-dimensional (2D) symmetric optimal box delivery motion. For the subtask-based formulation, the delivery task is divided into five subtasks: lifting, the first transition step, carrying, the second transition step, and unloading. To render a complete delivering task, each subtask is formulated as a separate optimization problem with appropriate boundary conditions. For carrying and lifting subtasks, the cost function is the sum of joint torque squared. In contrast, for transition subtasks, the cost function is the combination of joint discomfort and joint torque squared. Joint angle profiles are validated through experimental results using Pearson’s correlation coefficient (r) and root-mean-square-error (RMSE). Results show that the subtask-based approach is computationally efficient for complex box delivery motion simulation. This research outcome provides a practical guidance to prevent injury risks in joint torque space for workers who deliver heavy objects in their daily jobs.
A New Method for Rapid Optimization Design of a Subsonic Tandem Blade
Authors: Tao Yuan , Yu Xianjun , Liu Baojie
Published: December 2020

Tandem blade technology has been developed for years due to its capacity to bear higher aerodynamics than conventional configurations. Even so, there is still the tough problem of how to design tandem blades effectively and further improve blade performance. This paper tries to further understand the flow characteristics of tandem blades in order to present a new method of designing them under subsonic inflow conditions. Firstly, efforts were made to reveal the aerodynamic interaction between the forward blade (FB) and the aft blade (AB). Secondly, considering this aerodynamic interaction, the design principles and the camber line modification method were put forward, with which typical controlled diffusion airfoil (CD airfoil) isentropic Mach number distributions can be achieved for both FB and AB. Lastly, the optimizations were conducted on a 2D tandem blade and a transonic compressor with a tandem blade, respectively. The computation fluid dynamic (CFD) results show that the optimized tandem blade achieves a significant improvement for both 2D blade performance and transonic compressor characteristics at low speeds.
A Heuristic Method for Evaluating Accessibility in Web-Based Serious Games for Users with Low Vision
Authors: Salvador-Ullauri Luis , Acosta-Vargas Patricia , Gonzalez Mario , Luján-Mora Sergio
Published: December 2020

Nowadays, serious games have become a beneficial resource in the learning process; they are part of our culture and promote social inclusion. Designing accessible serious games is a complete challenge, even more for non-experts. Most existing serious games do not meet accessibility standards because of a lack of methods that include standards and help create more accessible serious games. For this reason, our research presents a heuristic method with three modifications to Giorgio Brajnik’s barrier walkthrough method and based on the Web Content Accessibility Guidelines 2.1 (WCAG 2.1). We defined 28 barriers for the users with low vision and the related impact and persistence variables by defining severity ranges to evaluate accessibility. This method allows measuring the accessibility of web-based serious games; the method proposed in this article can be a good help for non-experts. As a case study, this heuristic method was applied to 40 web-based serious games. The evaluators concluded that serious games should apply WCAG 2.1 to achieve an adequate and inclusive accessibility level. However, this study has limitations; the heuristic method depends on the evaluators’ experience. This work can contribute to studies related to accessibility heuristics in serious games; it can also help construct a software tool that applies WCAG 2.1 and helps experts and non-experts evaluate accessibility in serious games.
In Situ Rubber-Wheel Contact on Road Surface Using Ultraviolet-Induced Fluorescence Method
Authors: Rahman Jhonni , Shoukaku Yutaka , Iwai Tomoaki
Published: December 2020

This study examines the relationship between rubber-wheel and the contact area on the road surface. Ultraviolet-induced fluorescence microscopy was used to observe and measure the contact parts with pyranine as a dye solution. The high sensitivity to U.V. light makes it easy to distinguish contact and non-contact regions on a very small scale. The experiment was conducted in static and dynamic conditions to identify its influence on the apparent contact area of rubber-wheel and road surface. The in-situ observation of the contact area was captured and recorded using a high-speed digital camera with 1-inch a CMOS (complementary metal oxide semiconductor) sensor. Additionally, the contact area between rubber-wheel and road surface was measured using an analyzing software. The results show differences in static and dynamic contact conditions based on the operating parameters.
Stability Analysis and User Perception of Haptic Rendering Combining Virtual Elastic, Viscous and Inertial Effects
Authors: Gil Jorge Juan , Ugartemendia Axier , Diaz Inaki
Published: December 2020

Virtual Reality environments are being used on a mass scale in fields, such as Industry and Medicine. These virtual scenarios serve very different purposes such as prototyping, gaming and exercising. Interaction with the virtual environment is mainly achieved by senses of sight and hearing through devices, such as a mouse or VR glasses. To this end, haptic research started a few decades ago with the aim of improving this interaction through a sense of touch. A key element, hitherto not researched, is the effective combination of virtual elastic, viscous, and inertial effects in haptic feedback restored to the user and the safety implications of these feedback effects. It is of particular importance in neurological rehabilitation exercising, as interaction realism and safety are of great importance in therapy and for the patient. Therefore, this work addresses the stability analysis of the combination of three haptic effects—elastic, viscous, and inertial—and the subjective feeling on the part of users regarding different combinations of these effects. A theoretical analysis is presented with a view to establishing stable control principles, and a user-study was carried out in order to help understand the perception of users to different combinations of haptic effects.
Fast Implementation of NIST P-256 Elliptic Curve Cryptography on 8-Bit AVR Processor
Authors: Park Dong-won , Chang Nam Su , Lee Sangyub , Hong Seokhie
Published: December 2020

In this paper, we present a highly optimized implementation of elliptic curve cryptography (ECC) over NIST P-256 curve for an 8-bit AVR microcontroller. For improving the performance of ECC implementation, we focus on optimizing field arithmetics. In particular, we optimize the modular multiplication and squaring method exploiting the state-of-the-art optimization technique, namely range shifted representation (RSR). With optimized field arithmetics, we significantly improve the performance of scalar multiplication and set the speed record for execution time of variable base scalar multiplication over NIST P-256 curve. When compared with previous works, we achieve a performance gain of 17.3% over the best previous result on the same platform. Moreover, the execution time of our result is even faster than that over the NIST P-192 curve of the well-known TinyECC library. Our result shows that RSR can be applied to all field arithmetics and evaluate the impact of the adoption of RSR over the performance of scalar multiplication. Additionally, our implementation provides a high degree of regularity to withstand side-channel attacks.
Numerical Study on the Influence of Weir Construction on Near-Surface Atmospheric Conditions
Authors: Kang Misun , Kim Kyu Rang , Belorid Miloslav
Published: December 2020

Changes in land use/land cover (LULC) have an impact on weather and climate. Gumi Weir in the Nakdong River Basin of South Korea was built and led to changes of LULC in the river in which the width of the river was extended by 300 m on average from land to water. In this study, in order to analyze the effect of the LULC change on weather variables, the Large Eddy Simulation of Weather Research and Forecasting model was used based on the LULC before and after weir construction. The expanded river width increased the latent heat flux (LHF) and mixing ratio (q). The changes in the sensible heat flux (SHF) subsequently influenced the changes in the air temperature (Ta) around the river, where the LULC was directly changed. The distance of affected area due to the LULC change was investigated using a paired t-test. The results of the paired t-test revealed that an increase in the Nakdong river width led to a noticeable change in Ta and q with the mean distance of affected area up to 1100 m from the river shores. The results of this study could offer an understanding of the effects of small weir construction on local weather changes.