bluuebunny/crossref_metadata_2025 huggingface dataset:
Farmacocinética de la cefalexina administrada por vía oral conjuntamente con enalapril en caninos adultos
Authors: Prados A. P. , Kreil V. , Monfrinotti A. , Paes J. , Hallu R.
Published: July 2020

El objetivo de este estudio fue caracterizar la farmacocinética de la cefalexina administrada por vía oral a caninos y determinar si la administración conjunta con enalapril produce modificaciones en la misma. Se trabajó con 6 caninos mestizos sanos. Cada uno recibió una dosis única de 25 mg/kg de una suspensión de cefalexina (grupo 1) o cefalexina 20 minutos después de administrada una dosis oral única de 0,5 mg/kg de enalapril (grupo 2), con un diseño cross over (3x3). Las concentraciones plasmáticas de cefalexina se determinaron mediante el método microbiológico. El T>CIM fue siempre superior al 60% del intervalo posológico de 12 horas para ambos grupos. Los parámetros farmacocinéticos se compararon mediante el test de Wilcoxon (p≤0,05). Los resultados obtenidos se expresaron como media ± desvío estándar y para los grupos 1 y 2 fueron respectivamente: Cmax 27,66±4,20 y 26,51±6,04 μg/ml, Tmax 1,41±0,58 y 1,58±0,58 h, T1/2 1,55±0,12 y 1,62±0,22 h, ABC0-∞ 110,8±10,98 y 110,6±17,64 μg·h/ml, TMR 3,19±0,39 y 3,46±0,55 h. No se encontraron diferencias estadísticamente significativas entre los parámetros farmacocinéticos de efalexina obtenidos en cada grupo, por lo cual nuestros resultados sugieren que el tratamiento simultáneo con ambas drogas no modifica la farmacocinética del antibiótico.
Estrés oxidativo y actividad antioxidante en leche de vacas con mastitis subclínica
Authors: Aranguren A. J. , Flores C. A. , Márquez Y. C. , López-Ortega A. A.
Published: July 2020

La mastitis es una patología costosa en la ganadería lechera, su mayor incidencia ocurre en el periparto. El objetivo del presente estudio fue determinar el estrés oxidativo (EO) y la actividad antioxidante (AA) en la leche de vacas con mastitis. Se evaluaron 30 vacas mestizas Holstein x Carora en los primeros 150 días de lactancia, pertenecientes a una explotación comercial del estado Lara (Venezuela) divididas en dos grupos, cada uno de 15 animales: uno control y el otro con mastitis subclínica (MS). Se les extrajo dos muestras de leche en crioviales almacenados en nitrógeno líquido y una en tubos de ensayo que se mantuvieron a 8°C. Como indicadores de EO se cuantificaron dienos conjugados (DC) por método de Wallin y malondialdehído (MDA) por test de sustancias reaccionantes con el ácido 2-tío barbitúrico). La AA derivada de la enzima glutatión peroxidasa (GSH-Px) y del glutatión (GSH), fue evaluada por kit comerciales. Para establecer la significación estadística de los resultados se utilizó la prueba “t” de Student exigiéndose un 95% de certeza (p<0,05). Se observó un incremento de DC en el grupo con MS (1,41±0,12 nmoles/mg proteínas) en relación al grupo control (0,59±0,08; p<0,001), como también de MDA (0,38±0,02 nmoles/mg proteínas) al comparar con el valor control (0,29 ±0,02; p<0,001). La actividad de la GSH-Px se encontró elevada en el grupo con MS (40,75±5,09 mmoles/min/ml) al comparar con el grupo control (27,65±2,18; p<0,05). La concentración de GSH se presentó aumentada en el grupo con MS (273,71±37,51 mmoles/l) en relación al grupo control (150,00±21,17; p<0,05). Se concluye que la mastitis subclínica induce en la leche un estado de EO, acompañado con un aumento de la actividad antioxidante. Estos resultados apoyarían la suplementación controlada con antioxidantes durante el período del periparto bovino.
Estudio comparativo entre las técnicas convencionales e inmunohistoquímicas para el diagnóstico de leishmaniosis canina
Authors: Burna A. N. , Catuogno M. S. , Sánchez Negrette M. , Montenegro M. A.
Published: July 2020

En la leishmaniosis visceral (LV) los amastigotes pueden ser identificados por tinción con Giemsa en preparaciones o secciones de tejidos obtenidos de lesiones en piel, bazo, hígado y médula ósea, o bien aspirados de nódulos linfáticos. Se considera como resultado positivo, la aparición de una sola célula pa rasitada.El diagnóstico puede no ser exitoso debido a la baja sensibilidad de las técnicas histológicas tradicionales para detectar el parásito. Los métodos inmunohistoquímicos para detección de Leishmania sp en tejidos son simples, no requieren equipamiento especial y son altamente sensibles y específicos. El objetivo de este estudio fue evaluar las técnicas consideradas más sensibles y específicas para el diagnóstico de LV. Se obtuvieron muestras de caninos del nordeste argentino. Fueron seleccionados 42 pacientes con diagnóstico serológico reactivo a Leishmania sp, a los cuales se les extrajeron muestras mediante punción de médula ósea. También se obtuvieron muestras por biopsia de piel proveniente del pabellón auricular, para coloración HyE e inmunohistoquímica. En la observación microscópica de los extendidos de médula ósea, la coloración Giemsa permitió detectar amastigotes de Leishmania sp en los 42 animales investigados. Con la técnica inmunocitoquímica solo el 70% de las muestras reaccionó marcando los parásitos. En los cortes histológicos se pudieron identificar amastigotes de Leishmania sp con la técnica inmunohistoquímica en el 100% de los casos. Por su parte, la coloración HyE permitió detectar solamente un 65% de las muestras como positivas a la presencia de amastigotes. En el caso de bloques parafinados, la técnica inmunohistoquímica mostró mayor sensibilidad en la detección de amastigotes de Leishmania sp. En cuanto a las muestras citológicas, la coloración Giemsa mostró mayor utilidad, ya que permitió detectar no solo la presencia de amastigotes de Leishmania sp sino también otros microorganismos.
Incorporación de raíz de mandioca (Manihot sculenta) en la dieta de cerdos y su efecto sobre variables productivas
Authors: Koslowski H. A. , Picot J. A. , Sánchez S. , Calderón S. , Barrientos F.
Published: July 2020

En un programa de alimentación de cerdos existe una gran variedad de ingredientes que pueden utilizarse en la formulación de la dieta. El objetivo del trabajo fue verificar la conveniencia de utilizar raíz de mandioca en sustitución del maíz como recurso energético en cerdos, mediante la medición de las variables productivas consumo de alimento, ganancia diaria de peso vivo y conversión alimenticia. En el ensayo se utilizó un diseño completamente aleatorizado. Tuvo una duración de 28 días: 7 de adaptación y 21 de medición. La experiencia incluyó 12 animales y cuatro dietas: dieta base (DB) con maíz molido (71%) más concentrado proteico (29%); dietas 33%, 66% y 100%: DB a las cuales se les reemplazó el 33%, el 66% y 100% del maíz por raíz de mandioca respectivamente. El análisis estadístico se realizó con el software InfoStat/P v.2011. Los resultados indicaron que para las variables consumo de alimento (1,63-DB; 1,56-33%; 1,53-66%; 1,44-100%) y ganancia diaria de peso vivo (0,42-DB; 0,40-33%; 0,39-66%; 0,36-100%) no hubo diferencias entre los tratamientos DB, 33% y 66%, siendo a su vez iguales entre sí los tres niveles de mandioca, mientras que para la conversión (3,91-DB; 3,90-33%; 3,93-66%; 4,02-100%) no hubo diferencias entre los cuatro tratamientos (p<0,05), lo cual permite concluir que, excepto en el nivel de 100%, la inclusión de la raíz de mandioca en distintos niveles es una opción viable para la alimentación de cerdos.
OPEN GOVERNMENT AT GRASSROOTS LEVEL GOVERNMENT: E-GOVERNMENT SUCCESS FACTORS IN THE VILLAGE OF PEJAMBON, BOJONEGORO
Authors: Kusnan Mr.
Published: July 2020

The Government of Bojonegoro Regency was an Indonesia representative in Open Government Partnership (OGP) of Subnational Government Pilot Program. This achievement raised new energy to implement openness in rural government. This policy was also in line with Rural Law. Mean while, to implement government openness, the use of e-Government was highly prioritized. By e-Government, the governance would be effective and efficient. However, only one of 419 villages in Bojonegoro succesded in implementing government openness, that was Pejambon Village. This village won the best website in East Java in 2016 and 2017. There after, it took the first place as the most informative and transparant village in national level in 2018. This research uses qualitative descriptive research methods. The results show that in general the success of E-Government implementation in the open government in Pejambon village is influenced by three main factors. First governing factors that include vision, leadership, and funding. Second, organizational factors that include policy, human resources, and collaboration. Third, technical factors that include IT infrastructure and IT standars. However, there are some indicators that need to get attention and improved by the village government of Pejambon, namely Funding, human resources, and IT infrastructure. If not immediately handled seriously, the future will impede the implementation of open government in Pejambon village.Keywords: Open Government, Succes Factors, e-Government, Grassroots, Village
INTEGRATED LICENSING INFORMATION SYSTEM (SIJITU) APPLICATION IN LICENSING SERVICE (A Study at Department of Capital Investment and One-Stop Integrated Services in Ponorogo District)
Authors: Mindarti Lely Indah , Widodo Nurjati , Mahendra Mohammad Putra Surya
Published: July 2020

SIJITU (Integrated Licensing Information System) is an application developed by Department of Capital Investment and One-Stop Integrated Services (DPMPTSP) in Ponorogo District in order to provide effective, efficient, and transparent service in Non-Business Licensing Service. The reason behind SIJITU application is the rise of management information system so it can be utilized in the process of licensing service implementation at DPMPTSP in Ponorogo District. This research aims to identify, analyze, and describe SIJITU implementation in Non-Business Licensing Service at DPMPTSP in Ponorogo District that includes implementation strategy, resources involved, procedure and mechanism, and service improvement through SIJITU. This research is a descriptive research with qualitative approach. The method of data analysis used is data analysis of Miles, Huberman, and Saldana’s interactive model that involves data collection, data condensation, data presentation, and conclusion verification or description. The result of the research is that SIJITU application certainly helps the performance of public service in non-business license field that is held by DPMPTSP in Ponorogo District. Through SIJITU application, the service process can be done transparently with the tracking feature. DPMPTSP in Ponorogo District also tries to increase the officers’ ability through formal and non-formal education, and conducts socialization to the society regarding SIJITU application. Services procedure and mechanism through SIJITU can be known in details on the Standard Operating Procedure (SOP) of Licensing Service at DPMPTSP in Ponorogo District
THE ROLE OF E-GOVERNMENT ANALYSIS IN SUPPORTING PUBLIC TRUST AND INFORMATION DISCLOSURE IN THE CITY OF KENDARI
Authors: Tawai Adrian
Published: July 2020

The uniqueness of this research is the efforts of the Kendari City Government to realize public trust and information disclosure based on the principles of good governance. the purpose of this study is to describe the use of the Kendari City Government website as a means of providing public information. The research method is by observation and interviews with users of the Kendari city website.the results showed that the kendari city website is an online public information forum related to transparency, the government's official agenda, data banks, and news covering the performance of the Kendari City Government's performance. In addition, the commitment of the Mayor of Kendari's commitment to support the availability of online services to realize good governance and accountability. limitations in the use of online services are the lack of experts or human resources in the IT field who are placed to manage the website, have not maximized the performance of PPID in formulating and stating information that causes information flow to the website and the absence of legal instruments both in the text and context regulate the existence of the Kendari City Government website.
REGIONAL REGULATION CONCERNING WASTE MANAGEMENT IN KUTA, BADUNG TECHNICAL SERVICE UNIT
Authors: Dewi Nyoman Diah Utari
Published: July 2020

Implementation of Badung Regency Regional Regulation No. 7 of 2013 concerning Waste Management is an effort to find out about the policies implemented by the Badung Regency Government for waste management, especially in the Kuta area. This research is a qualitative research in which data is obtained from area observations, interviews, documentation and library research as well as online searches, systematically described in accordance with the formulation of the problem of implementing Regional Regulations and finding obstacles and solutions implemented in waste management in the Service Unit Kuta Technical, analyzed using the Merilee Implementation Model from S. Grindle, namely content of policy and context implementation. The results of an analysis of the Implementation of the Badung District Regulation No. 7 of 2013 concerning Waste Management in the Kuta Technical Services Unit, found weaknesses in the implementation of the Local Regulation policy and several obstacles encountered including the low willingness of the community to sort out their own garbage and often violate the disposal schedule rubbish, adding transportation facilities and infrastructure as well as the existence of Temporary Shelter in each Village / Kelurahan, and the involvement of Indigenous Villages in waste management by incorporating it into set of rules made by and for residents of a village and it’s called Awig-awig.
IMPLICATION OF BUREAUCRATIC REFORM POLICY IN ECHELON III AND IV IN THE ENVIRONMENTAL SERVICES OFFICE OF BLORA REGENCY
Authors: Purwanto Adi
Published: July 2020

The purpose of regional autonomy is to prosper the community by providing good public services to the community. In providing services to the public, the government uses bureaucracy. Bureaucracy thus requires employees with integrity, honesty, and capable. Along with the increasing demands and expectations of the people, the government needs to reform the bureaucracy by removing Echelon III and IV. The aim is for efficiency, effectiveness, and speed in decision making. This new policy makes uncertainty the fate of Echelon III and IV officials. This study aims to find out more deeply about Echelon III and IV reforms at the Environmental Services of Blora Regency. Researchers used descriptive qualitative methods. From the research findings, it was concluded that: a. intensive and dialogical socialization is needed; b. echelon officials who have already approached retirement age, resign themselves to government policies regarding the elimination of echelon III and IV; c. Echelon officials who are young and productive, prefer structural positions because structural positions will get more facilities and welfare than functional positions; d. staff who have the potential, diligently follow the training and have a visionary view, prefer functional positions because if you can meet the credit score, can be promoted faster, and impact on income will increase.
CASE STUDY ON ENHANCED LANDFILL MINING AT MONT-SAINT-GUIBERT LANDFILL IN BELGIUM: MECHANICAL PROCESSING, PHYSICO-CHEMICAL AND MINERALOGICAL CHARACTERIZATION OF FINE FRACTIONS <4.5 MM
Authors: Vollprecht Daniel , Hernández Parrodi Juan Carlos , Lucas Hugo Ignacio , Pomberger Roland
Published: July 2020

Fine fractions obtained by mechanical processing of excavated waste constitute a challenge for (enhanced) landfill mining projects. These fractions are mainly composed of humified organic and weathered inorganic compounds, whereas metals and calorific fractions are depleted. In this study we present data on the chemical composition and grain size distribution of the fine fractions <4.5 mm, as well as on the mineralogical composition of the two finest subfractions (0.18 to 0.5 mm and <0.18 mm). Chemical analyses indicate no trend regarding the enrichment or depletion of heavy metals in the different particle size ranges. Leaching from the finer fractions is somewhat higher than from the coarser fractions (i.e. 1.6 to 4.5 mm and 0.5 to 1.6 mm), although the fraction 0.18 to 0.5 mm shows the lowest overall leaching. Pseudo-total contents of Cu, Zn, Cd, Hg and Pb and leachable contents of Ni exceed Austrian limit values for the production of soil substitutes from wastes. Electron microprobe analyses indicate that Zn and Pb, which exceed limit values for pseudo-total content, are present as Fe-Zn alloy, ZnS and ZnSO4, and metallic Pb and Pb-Ca phosphate, respectively. In summary, dry-mechanical processing, which is a feasible method in the particle size range >4.5 mm, showed a limited effect in the range <4.5 mm. Removal of Pb- and Zn-containing phases is highly challenging due to the diverse mineralogy and fine grain size of few µm. Consequently, it seems unlikely that the Austrian limit values for soil substitutes can be met.
Treatment of Landfill Leachate at a Remote Closed Landfill Site on the Isle of Wight
Authors: Tim Robinson
Published: July 2020

Safe treatment and disposal of leachates is an important issue at many old landfill sites, where the ingress of rainfall or groundwater is a significant issue requiring consideration. Such leachates may typically be relatively weak, but flows are often characterised by large seasonal variations, in response to winter rainfall. This paper compiles and presents long-term data from a case study on the Isle of Wight, UK.

This paper highlights how a successful treatability trial using representative leachates can help predict the effectiveness of a large-scale treatment plant when treating landfill leachates biologically.

Bleakdown leachate treatment plant effectively removes all concentrations of ammoniacal-N within the weak leachate generated by the site, ensuring that the discharge consent set by the Environment Agency is achieved consistently. The site is completely unmanned and remote, where monitoring technicians are only required to attend site twice per month in order to assess the success of the biological process. Through an online SCADA control system, operation of the treatment plant can be monitored and controlled remotely, trends in results can be observed, and daily data and treatment records downloaded. This treatment plant is an example of how leachate from old closed landfills can be effectively managed, with very low costs of operation, maintenance and site attendance.

This paper presents comprehensive analytical and volumetric treatment data from the Bleakdown LTP, before presenting practical steps that would enable this success to be replicated at similar remote closed landfill sites.
INDEX TO EVALUATE CLOSED LANDFILLS BASED ON LEACHATE PARAMETERS
Authors: Mahler Claudio Fernando , de Almeida Julia Righi , Bassin João Paulo
Published: July 2020

After the end of their useful life, waste landfills and their surroundings should continue to be monitored constantly. The main concern is pollution of groundwater and surface water from leachate, posing a risk to public health. The effluent generated by closed landfills may have equal or greater potential for contamination compared to active landfills. The proposal of an index to evaluate the landfill conditions after closure was the main motivation for this work. The insufficiency of data on the waste entering these areas causes uncertainty as to how long the material will continue to degrade. In this article, the presence of polluting elements in the leachate of a deactivated landfill was evaluated through the characterization of the effluent during a ten-year monitoring period. From the study of existing indexes to evaluate the leachate of closed waste disposal areas, we verified the importance given to certain parameters that are not relevant for Brazilian landfills, in which the presence of organic matter is high. The present work contributes by generating information for a better understanding of the impacts caused by landfills in Brazil and in most countries of the Third Word, in which organic waste represents at least 50% of the waste discarded in landfills. With the application of the proposed Deactivated Landfill Assessment Index (DLAI), involving four-parameter analysis (pH, BOD, COD and ammoniacal nitrogen), possible threats of pollution can be detected, allowing prioritizing areas for remediation and better allocation of resources.
Improvement the Mechanical Characteristics of Alloy Steel DIN 41Cr4 by Shot Peening
Authors: Mahmood Zeina shaker , Chiad Jumaa Salman
Published: July 2020

The effects of shot peening treatment (SPT) were studied at (10,20, and 30) minutes on the rotating bending fatigue behavior and the behavior of the alloy steel DIN 41Cr4 vibrations. The hardness test, tensile test, constant amplitude fatigue tests, and the vibration measurements were performed on samples with and without cracks at room temperature (RT), also, the fracture surface was examined and analyzed by a Scanning Electron Microscope (SEM). The results of the investigations, for example, Stress to Number of cycles to failure (S-N) curves, fatigue strength improvement factor of 5% to 10%, the decreasing percentage of maximum Fast Fourier Transform (FFT) acceleration of the shot-peened condition were compared to untreated conditions ranging between 25% and 40%. All these improvements occurred for up to 20 minutes of shot peening time (20 SPT), exceeding that time the fatigue behavior tended to decrease due to high roughness and the generation of tensile residual stress.
Study the Effect of Catalyst -to- Oil Ratio Parameter (COR) on Catalytic Cracking of Heavy Vacuum Gas Oil
Authors: Alrubaye Saleem Mohammad
Published: July 2020

This work deals with the production of light fuel cuts of (gasoline, kerosene and gas oil) by catalytic cracking treatment of secondary product mater (heavy vacuum gas oil) which was produced from the vacuum distillation unit in any petroleum refinery. The objective of this research was to study the effect of the catalyst -to- oil ratio parameter on catalytic cracking process of heavy vacuum gas oil feed at constant temperature (450 °C). The first step of this treatment was, catalytic cracking of this material by constructed batch reactor occupied with auxiliary control devices, at selective range of the catalyst –to- oil ratio parameter (  2, 2.5, 3 and 3.5) respectively.  The conversion of heavy vacuum gas oil which was obtained, reaches to (50, 70, 75 and 80) % for (2, 2.5, 3 and 3.5 catalysts -to- oil ratio parameter respectively. The second step for this study was distillation of this cracking heavy vacuum gas oil liquid by atmospheric distillation device for these several catalyst -to- oil ratio parameter, according to obtained light fuel cuts (gasoline, kerosene and gas oil). The percentage volume of light fractions at various COR are (7, 25 and 18) for COR 2, (10, 20 and 40) for COR 2.5, (10, 30 and 35) for COR 3 and (15, 30 and 35) for COR 3.5  which separates according to its boiling point. The light cuts were distilled by atmospheric distillation device in order to obtained distillation curve. The third step was study the major physical and chemical properties for feed (heavy vacuum gas oil) and catalytic cracking liquid of HVGO at various COR with its light fuel fractions, the results refers to acceptable properties compared with other commercial properties.
Using Adaptive Neuro Fuzzy Inference System to Predict Rate of Penetration from Dynamic Elastic Properties
Authors: Khudaier Yasser abbas , Kadhim Fadhil Sarhan , Yousif Yousif Khalaf
Published: July 2020

Rate of penetration plays a vital role in field development process because the drilling operation is expensive and include the cost of equipment and materials used during the penetration of rock and efforts of the crew in order to complete the well without major problems. It’s important to finish the well as soon as possible to reduce the expenditures. So, knowing the rate of penetration in the area that is going to be drilled will help in speculation of the cost and that will lead to optimize drilling outgoings. In this research, an intelligent model was built using artificial intelligence to achieve this goal.  The model was built using adaptive neuro fuzzy inference system to predict the rate of penetration in Mishrif formation in Nasiriya oil field for the selected wells. The mean square error for the results obtained from the ANFIS model was 0.015. The model was trained and simulated using MATLAB and Simulink platform. Laboratory measurements were conducted on core samples selected from two wells. Ultrasonic device was used to measure the transit time of compressional and shear waves and to compare these results with log records. Ten wells in Nasiriya oil field had been selected based on the availability of the data. Dynamic elastic properties of Mishrif formation in the selected wells were determined by using Interactive Petrophysics (IP V3.5) software and based on the las files and log records provided. The average rate of penetration of the studied wells was determined and listed against depth with the average dynamic elastic properties and fed into the fuzzy system. The average values of bulk modulus for the ten wells ranged between (20.57) and (27.57) . For shear modulus, the range was from (8.63) to (12.95) GPa. Also, the Poisson’s ratio values varied from (0.297) to (0.307). For the first group of wells (NS-1, NS-3, NS-4, NS-5, and NS-18), the ROP values were taken from the drilling reports and the lowest ROP was at the bottom of the formation with a value of (3.965) m/hrs while the highest ROP at the top of the formation with a value (4.073) m/hrs. The ROP values predicted by the ANFIS for this group were (3.181) m/hrs and (4.865) m/hrs for the lowest and highest values respectively. For the second group of wells (NS-9, NS-15, NS-16, NS-19, and NS-21), the highest ROP obtained from drilling reports was (4.032) m/hrs while the lowest value was (3.96) m/hrs. For the predicted values by ANFIS model were (2.35) m/hrs and (4.3) m/hrs for the lowest and highest ROP values respectively.
Flexural Behavior of Reinforced Concrete Beams Reinforced with 3D-Textile Composite Fiber
Authors: Abdulghani Mays R. , Ali Dr. Ahmed S.
Published: July 2020

Normal concrete is weak against tensile strength, has low ductility, and also insignificant resistance to cracking. The addition of diverse types of fibers at specific proportions can enhance the mechanical properties as well as the durability of concrete. Discrete fiber commonly used, has many disadvantages such as balling the fiber, randomly distribution, and limitation of the Vf ratio used. Based on this vision, a new technic was discovered enhancing concrete by textile-fiber to avoid all the problems mentioned above. The main idea of this paper is the investigation of the mechanical properties of SCC, and SCM that cast with 3D AR-glass fabric having two different thicknesses (6, 10 mm), and different layers (1,2 layers). As well as micro-steel fiber with 1.25% volume fraction was used. Sixteen rectangular reinforced concrete beam specimens have been tested to study the behavior of their flexural strength. The results concluded that utilizing 3D-TFs with mortar mixture gave significantly higher enhancement for the load-carrying capacity than the concrete mixture. The utilization of 3D-TFs and micro-steel fiber together in the SCM mix gave better results. The stiffness of the specimens was improved with increasing the thickness and the number of textile fiber layers.
Evaluating the Uses of Concrete Demolishing Waste in improving the Geotechnical Properties of Expansive Soil
Authors: Saeed Safin B. , Rashed Kamal Ahmad
Published: July 2020

Expansive soil is one of the most serious problems that face engineers during the execution of any infrastructure projects. Soil stabilization using chemical admixture is one of the most traditional and widespread methods of soil improvement. Nevertheless, soil improvement on site is one of the most economical solutions for many engineering applications. Using construction and demolishing waste in soil stabilization is still under research., The aim of this study is to identify the effect of using concrete demolishing waste (CDW) in soil stabilization. Serious tests were conducted to investigate the changes in the geotechnical properties of the natural soil stabilized with CDW. From the results, it is concluded that the swelling potential of the expansive soil reduced and dramatic increases in unconfined compressive strength (UCS) value up to 3 times of its original value was reported. The results indicate that CDW is an economical solution to be used in soil stabilization whereas it is a sustainable idea to recycle constructional wastes and solve the continued need for the more landfilling area.
Securing Physical Layer for FHSS Communication System Using Code andPhase Hopping Techniques in CDMA, System Design and Implementation
Authors: Mohammed Saifuldeen A.
Published: July 2020

The Frequency-hopping Spread Spectrum (FHSS) systems and techniques are using in military and civilianradar recently and in the communication system for securing the information on wireless communications link channels, for example in the Wi-Fi 8.02.X IEEE using multiple number bandwidth and frequencies in the wireless channel in order to hopping on them for increasing the security level during the broadcast, but nowadays FHSS problem, which is, any Smart Software Defined Radio (S-SDR) can easily detect a wireless signal at the transmitter and the receiver for the hopping sequence in both of these, then duplicate this sequence in order to hack the signal on both transmitter and receiver messages using the order of the sequences that will be recognized for next transmissions. In 2017 Code and Phase Hopping Techniques are both proposed to resolve the most recent problem in security-related, but not with FHSS, therefore in this paper presents a new composed proposed system will progress Phase Shift and Code Hopping in Code Division Multiplexing Access (CDMA) to complement with FHSS; because the wireless Communications systems security in the last years became a nightmare for some individuals, also companies, and even countries, also join them needing for higher bits rate in the wireless channels; because of next-generation communication system 5G-6G and the evolution in social networking, IoT, stream media, IoE, visualizations, and cloud computing. The new ideas can be applicable for a large number of users, also fast implementation without synchronization, as well as without any focus on encryption or keys-exchanges, at completion all results are simulation in MATLAB R2017b, the results have been tested by using 8 users in the same time, also our results showing promises effects on security for both applied systems Phases Shift and Codes Hopping especially the Code Hopping, therefor; our results encouraged us to complete research and compare our system with other.
Genetic factors related to the immune system in subjects at risk of developing Alzheimer's disease
Authors: Prendecki Michał , Kowalska Marta , Łagan-Jędrzejczyk Urszula , Piekut Thomas , Krokos Aleksandra , Kozubski Wojciech , Dorszewska Jolanta
Published: July 2020

Alzheimer’s disease is the most common neurodegenerative disease and the cause of dementia. Although the pathomechanisms underlying Alzheimer’s disease have not been fully elucidated, there is evidence that genetic and environmental factors contribute to its development. Immune system changes, both environmentally-induced and, as a result of predisposing genetics, are implicated in Alzheimer’s disease etiopathogenesis. Genes associated with immune system dysfunction in Alzheimer’s disease include CLU, BIN1, CR1, ABCA7, HLA-DRB1, TREM2, EPHA1, and CD2AP. In particular, BIN1 and CLU, aberrations in which are thought to promote neurodegeneration by dysregulating exocytosis and immune processes, together with the E4 variant of the APOE gene, are among the most common genetic risk factors for Alzheimer’s disease. While the relationships between these genes in Alzheimer’s disease have been examined, little information exists regarding their role as variables predisposing first or second-degree relatives of Alzheimer’s disease patients to the illness. The rationale of this review is to suggest that individuals with a family history of Alzheimer’s disease who have the BIN1-T/T variant may be at significant risk of developing Alzheimer’s disease. Also, the unfavorable BIN1-T variant is independent of APOE E4-associated risk. People at risk of developing Alzheimer’s disease are more often carriers of the protective C-variant of the CLU gene, the presence of which might be associated with later-onset dementia observable within this high-risk group. It seems BIN1 and CLU together with, albeit independent of APOE E4, may be among the factors predisposing individuals with a family history of Alzheimer’s disease to developing the illness.
Antidepressant pathways of the Chinese herb jiaweisinisan through genetic ontology analysis
Authors: Chen Jie , Huang Yunling , Li Ling , Niu Jie , Ye Weiqiong , Wang Yunnan , Yan Can , Wu Lili
Published: July 2020

Active compounds and corresponding targets of the traditional Chinese herb, jiaweisinisan, were obtained from systems pharmacological database and placed into ClueGO for gene ontology analysis. The targets of depression were obtained from the Online Mendelian Inheritance in Man, the Therapeutic Target Database, and the Pharmacogenomics Knowledge Base. Compound-target and target-pathway networks were constructed using Cytoscape, and then their topological parameters were analyzed. The targets of jiaweisinisan and depression were mapped to pathways, thereby constructing antidepressant pathways of jiaweisinisan. It was found that jiaweisinisan has 82 different active compounds and 306 relevant potential targets. Also, 107 unrepeatable targets related to depression were found. In all, 26 common targets were found to be the direct anti-depression targets of jiaweisinisan and 9 pathways of jiaweisinisan related to depression were divided into three modules (synaptic transmission, cell apoptosis, and immune-inflammatory). The jiaweisinisan formula was found to have synergistic antidepressant effects due to aspects of its herb composition and the active compounds therein, giving rise to potential targets and signaling pathways related to depression. Its antidepressant mechanisms were found to mainly involve the regulation of synaptic transmission, cell apoptosis, and immune-mediated inflammation.
Decoding spectro-temporal representation for motor imagery recognition using ECoG-based brain-computer interfaces
Authors: Xu Fangzhou , Zheng Wenfeng , Shan Dongri , Yuan Qi , Zhou Weidong
Published: July 2020

One of the challenges in brain-computer interface systems is obtaining motor imagery recognition from brain activities. Brain-signal decoding robustness and system performance improvement during the motor imagery process are two of the essential issues in brain-computer interface research. In conventional approaches, ineffective decoding of features and high complexity of algorithms often lead to unsatisfactory performance. A novel method for the recognition of motor imagery tasks is developed based on employing a modified S-transforms for spectro-temporal representation to characterize the behavior of electrocorticogram activities. A classifier is trained by using a support vector machine, and an optimized wrapper approach is applied to guide selection to implement the representation selection obtained. A channel selection algorithm optimizes the wrapper approach by adding a cross-validation step, which effectively improves the classification performance. The modified S-transform can accurately capture event-related desynchronization/event-related synchronization phenomena and can effectively locate sensorimotor rhythm information. The optimized wrapper approach used in this scheme can effectively reduce the feature dimension and improve algorithm efficiency. The method is evaluated on a public electrocorticogram dataset with a recognition accuracy of 98% and an information transfer rate of 0.8586 bit/trial. To verify the effect of the channel selection, both electrocorticogram and electroencephalogram data are experimentally analyzed. Furthermore, the computational efficiency of this scheme demonstrates its potential for online brain-computer interface systems in future cognitive tasks.
Topological properties of the resting-state functional network in nonsyndromic cleft lip and palate children after speech rehabilitation
Authors: Rao Bo , Cheng Hua , Fan Yang , Zhang Wenjing , Chen Renji , Peng Yun
Published: July 2020

Speech therapy has been widely used as an essential therapy for compensatory articulation errors in nonsyndromic cleft lip and palate patients. We sought to identify potential biomarkers of nonsyndromic cleft lip and palate children after speech rehabilitation based on resting-state fMRI and graph theory techniques. We scanned 28 nonsyndromic cleft lip and palate and 28 typically developing children for resting-state fMRI on a 3T MRI scanner. Functional networks were constructed, and their topological properties were obtained for assessing between-group differences (two-sample t-tests). Also, language clear degree scale scores were obtained for correlation analysis with the topological features in nonsyndromic cleft lip and palate patients. Significant between-group differences of local properties were detected in brain regions involved in higher-order language and social cognition. There were no significant correlations between topological feature differences and language clear degree scale scores in nonsyndromic cleft lip and palate patients. Graph theory provided valuable insight into the neurobiological mechanisms of speech rehabilitation in nonsyndromic cleft lip and palate patients. The global network features, small-world index, nodal clustering coefficient, and nodal shortest path length may represent potential imaging biomarkers for the estimation of effective speech rehabilitation.
Melatonin improves memory defects in a mouse model of multiple sclerosis by up-regulating cAMP-response element-binding protein and synapse-associated proteins in the prefrontal cortex
Authors: Saeed Alghamdi Badrah , Abdulbaset AboTaleb Hanin
Published: July 2020

Multiple sclerosis is a progressive autoimmune disorder of the myelin sheath and is the most common inflammatory disease of young adults. Up to 65% of multiple sclerosis patients have cognitive impairments such as memory loss and difficulty in understanding and maintaining attention and concentration. Many pharmacological interventions have been used to reverse motor impairments in multiple sclerosis patients; however, none of these drugs improve cognitive function. Melatonin can diffuse through the blood-brain barrier and has well-known antioxidant and anti-inflammatory properties with almost no side effects; it is, therefore, a promising neuroprotective supplement for many neurological diseases, such as multiple sclerosis, Alzheimer’s disease, Parkinson’s disease, ischemic stroke, and fibromyalgia. However, only some researches have assessed the effect of melatonin on cognitive dysfunction in multiple sclerosis. Here, we evaluated the effects of melatonin supplementation on memory defects induced by cuprizone in a mouse model of multiple sclerosis. Cuprizone (400 mg/kg) and melatonin (80 mg/kg) were administered to SWR/J mice daily for 5 weeks. Open field, tail-flick, and novel object recognition behavioral tests were performed. Also, expression of cAMP-response element-binding protein, synaptophysin, and postsynaptic density protein 95 were measured in the prefrontal cortex. Melatonin significantly improved the memory defects induced by cuprizone toxicity by up-regulating cAMP-response element-binding protein and by increasing expression of the synapse-associated synaptophysin and postsynaptic density protein 95 genes in the prefrontal cortex. These results indicate that melatonin may provide protective effects against memory impairments associated with multiple sclerosis.
Hyperkalemia in heart failure: current treatment and new therapeutic perspectives
Authors: Minà Chiara , Ajello Laura , Gesaro Gabriele Di , Falletta Calogero , Clemenza Francesco
Published: July 2020

Hyperkalemia in heart failure is a condition that can occur with relative frequency because it is related to pathophysiological aspects of the disease, and favored by drugs that form the basis of chronic cardiac failure therapy. Often, associated comorbidities, such as kidney failure or diabetes mellitus can further adversely affect potassium levels. Hyperkalemia can result in acute and even severe clinical manifestations that put patients at risk. On the other hand, the finding of hyperkalemia in a chronic context can lead to a reduction in dosages or to suspension of drugs such as angiotensin-converting enzymes inhibitor, angiotensin receptor blocker, angiotensin receptor neprilysin inhibitor, and mineralcorticoid receptor antagonist, first line in the treatment of the disease, with negative effects in prognostic terms. Therapies for the correction of hyperkalemia have so far mainly concerned the treatment of acute clinical pictures. Newly developed molecules, such as patiromer or sodium zirconium cyclosilicate, now open new prospectives in the long-term management of hyperkalemia, and allow us to glimpse the possibility of a better titration of the cardinal drugs for heart failure, with consequent positive effects on patient prognosis. The aim of this review is to focus on the problem of hyperkalemia in the setting of heart failure, with particular regard to its incidence, its prognostic role, and the underlining pathophysiological mechanisms. The review also provides an overview of therapeutic strategies for correcting hyperkalemia in acute and chronic conditions, with a focus on the new potassium binders that promise to improve management of heart failure.
PENERAPAN HORINET DAN VERTINET UNTUK PENINGKATAN PRODUKSI RUMPUT LAUT DAN PENGEMBANGAN DESA WISATA BAHARI
Authors: Mustafa Ahmad , Kasim Ma'ruf , Ibrahim Muhammad Nuh , Jalil Wardha
Published: July 2020

Produksi rumput laut Indonesia saat ini terus mengalami berbagai persoalan.  Salah satu masalah serius adalah serangan hama  ikan herbivora. Penerapan Horinet dan VertiNet adalah solusi untuk melindungi dan  meningkatkan produksi rumput laut. Horinet adalah Horisontal Net yang merupakan alat budidaya kurungan horizontal. Vertinet adalah Vertikal Net yang merupakan alat budidaya rumput laut vertikal. Keduanya dibuat dari pipa paralon dan jaring. Metode kegiatan antara lain :  survei penentuan lokasi, koordinasi, pelatihan, pendampingan dan bimbingan tehnis, pemasangan horinet, pengontrolan dan pengamatan pertumbuhan rumput laut. Hasil kegiatan menggambarkan bahwa pemerintah desa, instansi terkait, dan masyarakat sangat antusias dengan pelaksanaan kegiatan ini.  Kegiatan berjalan sangat baik dengan didukung oleh pembudidaya rumput laut. Pelatihan dilakukan dengan pelibatan masyarakat, perakitan dilakukan langsung oleh masyarakat. Kegiatan pelatihan dibagi dalam kelompok yang bekerja secara bersama-sama. Hasil perakitan di susun dengan baik sebelum di lakukan pembudidayaan rumput laut di lokasi terpilih. Perawatan alat dilakukan langsung oleh kelompok masyarakat. Penerapan vertinet dan horinet adalah metode terbaik dalam budidaya dan sekaligus  sebagai destinasi wisata. Metode budidaya ini dapat meningkatkan produksi dan pendapatan masyarakat. Metode ini dapat memberikan harapan baru bagi peningkatan pendapatan dan kesejahteraan masyarakat pesisir.
PENGEMBANGAN BIOGAS DARI SAMPAH UNTUK ENERGI LISTRIK DAN BAHAN BAKAR KOMPOR DI TPA CILOWONG, KOTA SERANG, BANTEN
Authors: Annur Shohifah , Kusmasari Wyke , Wulandari Retno , Sumiati Sumiati
Published: July 2020

Kegiatan pengabdian ini bertujuan untuk membuat pembangkit listrik yang berasal dari sampah organik di TPA Cilowong, Kota Serang Banten. TPA Cilowong merupakan tempat pembuangan pusat sampah yang berasal dari seluruh daerah yang ada di wilayah Kota Serang Banten. Setiap harinya TPA ini menerima 5 truk sampah pasar yang dibuang pada landfill dan belum dimanfaatkan secara optimal.  Padahal sampah ini dapat diolah menjadi biogas untuk penerangan listrik TPA dan bahan bakar kompor di dapur umum TPA. Instalasi biogas dibuat dengan satu digester (penampung biogas) berbentuk bulat yang bisa menampung sampah sebesar 6 m3. Untuk pertama kali pemakaian, dibutuhkan starter kotoran sapi yang dicampur dengan sampah organik pasar sebagai starter dengan perbandingan sampah : kotoran sapi = 5: 1. Kegiatan ini bekerja sama dengan 30 orang mahasiswa KKM dan pengurus TPA Cilowong. Biogas dari sampah ini bisa digunakan untuk penerangan listrik di TPA dan sebagai sumber gas di dapur umum TPA.
The influence of spatial location on same-different judgments of facial identity and expression
Authors: Starks Maurryce , Shafer-Skelton Anna , Paradiso Michela , Martinez Aleix M. , Golomb Julie
Published: July 2020

The “spatial congruency bias” is a behavioral phenomenon where two objects presented sequentially are more likely to be judged as being the same object if they are presented in the same location (Golomb et al., 2014), suggesting that irrelevant spatial location information may be bound to object representations. Here, we examine whether the spatial congruency bias extends to higher-level object judgments of facial identity and expression. On each trial, two real-world faces were sequentially presented in variable screen locations, and subjects were asked to make same-different judgments on the facial expression (Experiments 1-2) or facial identity (Experiment 3) of the stimuli. We observed a robust spatial congruency bias for judgements of facial identity, yet a more fragile one for judgements of facial expression. Subjects were more likely to judge two faces as displaying the same expression if they were presented in the same location (compared to in different locations), but only when the faces shared the same identity. On the other hand, a spatial congruency bias was found when subjects made judgements on facial identity, even across faces displaying different facial expressions. These findings suggest a possible difference between the binding of facial identity and facial expression to spatial location.