bluuebunny/crossref_metadata_2025 huggingface dataset:
Pregnancy through the lens of breast cancer survivors: A qualitative study in an Iranian setting
Authors: Azizi Marzieh , Ebrahimi Elham , Moghadam Zahra Behboodi , Shahhosseini Zohreh , Modarres Maryam
Published: September 2022

Background
As recently the number of breast cancer (BC) survivors has increased, the potential desire to conceive a child after completing treatments is a significant concern among survivors. This study aimed to explore the experiences and perceived needs of pregnancy through the lens of BC survivors.
Methods
This qualitative study with content analysis approach was conducted between August 2021 and February 2022. Data was collected through in-depth semi-structured, face-to-face interviews, and 16 BC survivors were selected by purposive sampling at two referral centers in Sari, Northern Iran. Interviews were audio recorded, transcribed verbatim, and analyzed concurrently. Then interviews were coded and categorized using MAXQDA 12.
Results
As a result of data analysis, six main categories and 13 subcategories were extracted. Six main categories including "pregnancy and childbirth problems", "maternal mental health problems", "social problems", "marital instability", "need to support and need to resort to spirituality".
Conclusions
Since pregnancy is a stressful event in women's life, especially for women with BC, these women need to be counseled and prepared for a healthy pregnancy by their healthcare providers. Also, improving the healthcare professional's knowledge regarding the pregnancy complications of these women is crucial to providing high-quality care for BC survivors.
Cardiovascular Risk Factors Predict Age at Death in 60-year Follow-up of the Seven Countries Study
Authors: Puddu Paolo Emilio , Menotti Alessandro , Jac David R Jr , Adachi Hisashi , Kafatos Anthony , Tolonen Hanna
Published: September 2022

Objectives. To study age at death (AD) and its determinants in cohorts of middle-aged men followed-up until extinction.
Material and Methods. A total of 9063 middle aged men enrolled in 10 cohorts of 6 countries (USA, Finland, the Netherlands, Italy, Greece and Japan) within the Seven Countries Study were examined and then followed-up for 60 years until extinction. AD was computed and a small number of risk factors were tested through multiple linear regression as possibly related to attained AD.
Results. AD ranged across cohorts from 71.8 years in East Finland and 80.5 years in Crete with levels roughly lower in the USA and Northern Europe and higher elsewhere. Across cohorts the correlation coefficients of systolic blood pressure (R=-0.58) and of CVD prevalence (R=-0.65) versus average AD were the only significant ones. At individual level in the pool of all cohorts, a multiple linear regression model showed that age, vigorous physical activity, never and ex-smokers were favorably related to AD, while the reverse was true for systolic blood pressure, heart rate, serum cholesterol, CVD prevalence and silent ECG abnormalities. BMI had a parabolic relationship with AD. The predicting power of single risk factors, expressed in years gained or lost, was relatively small, but arbitrary combinations of several of them produced large differences in AD.
Conclusions. A small number of CVD risk factors were strongly associated with AD in a life-long follow-up.
Chaotic guided local search algorithm for solving optimization problems
Authors: Naanaa Anis
Published: September 2022

Chaos optimization algorithm (COA) can be an interesting alternative in a global optimization problem. Due to the non-repetition and ergodicity of chaos, it can explore the global search space at higher speeds than stochastic searches that depend on probabilities. To adjust the solution obtained by COA, guided local search algorithm (GLS) is integrated with COA to form a hybrid algorithm. The results show that the present algorithms significantly outperforms the existing methods in terms of con- vergence speed, numerical stability and a better optimal solution than other algorithms.
The COVID-19 Pandemic and Access to Vaccination in Bangladesh: a Critical Review
Authors: Haque Md. Emdadul
Published: September 2022

This paper delineates the diverse perspectives of the vicious COVID-19 pandemic and access to vaccination in Bangladesh. It also depicts the discrepancies as to access to vaccine and vaccination campaign aside from assorted socio-economic impacts and challenges in Bangladesh with plausible way-outs. The fight for combating the demonized coronavirus is laudable amid the country’s limited resources, vulnerable healthcare system and vaccine hesitation. But the estimated cost of vaccination is under criticism because the country has received a substantial amount of vaccines as gift or free of cost donation from rich countries especially from the United States. Due to the pandemic, the socio-economic loss sustained by the country has created extra burden for the economy. No doubt, the coronavirus has taken an acid test of the global healthcare system. Even the economically advanced countries with sophisticated healthcare facilities have experienced the horrific fatality of the pandemic for a long time. But during the pandemic, the world has witnessed further polarization of the countries with major political and economic power dynamics in the name of coordinated fighting of the persisting crisis. Together with the financial constraints of low-income countries in Africa and Asia, the vaccine crisis and monopoly caused by the profit-driven attitude of most multinational pharma companies and geopolitical interests of some high income countries have galvanized the global vaccine inequity undermining the notion of distributive justice with a few exceptions. But the contagious coronavirus taught that people’s safety of a particular country is not possible without safety of other countries. Most existing papers on the COVID-19 pandemic linking Bangladesh depict its various detrimental impacts from health science and socio-economic aspects. But this paper critically reviews the chronological aspects of the COVID-19 pandemic in Bangladesh starting from influx of the virus to its all-out combating measures highlighting human casualty, advent of vaccine, vaccine inequity, access to vaccination, vaccine diplomacy, campaign, hesitation and rerated constraints along with prevailing as well as post COVID-19 socio-economic impacts.
Co-infection at the Time of Hospital Admission in Patients with COVID-19 Infection
Authors: Cherian Susan , Jangla Sunayana Mukesh , Naidu Raji
Published: September 2022

Background: Co-infections with Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) lead to unfavourable outcomes. However, data on prevalence of various co-infections in SARS-CoV-2 positive patients on admission to the hospital is sparse. This study focusses on assessing co-infection rates and common pathogenic bacteria and fungus involved in these patients.

Methods: Patients admitted between April 2020 and December 2020 with Corona Virus Disease-2019 (COVID-19) were included. Criteria for co-infection using definitions were developed. All microbiological investigations of these patients performed within first 48 hours of admission were analysed. Their demographic characteristics along with existing co-morbidities, presenting symptoms, other laboratory findings on admission and clinical outcome were also reviewed.

Results: Of 1566 patients, 60% were males.64% belonged to 13-65 years age-group. 4% of COVID-19 positive patients were co-infected. 451 samples were received for culture of which urine were 66%, blood 23% and sputum 11%. 15% samples showed growth of which urine were 19%, blood 10% and sputum 2%. Bacteria isolated were 91% and fungus 9%. The common bacteria isolated were E. coli 46%, Klebsiella pneumoniae 25%, Stenotrophomonas maltophila 6% and Pseudomonas aeruginosa 4%. The common fungus isolated was Candida species 7%.10% of COVID-19 positive patients with co-infection expired and 90% recovered.

Conclusion: We report a 4% rate of bacterial and fungal co-infection in COVID-19 positive patients on admission mostly related to Enterobacterales, Non-fermenting Gram-negative bacilli and Candida species. This data can be valuable in optimising the use of antibiotics and antifungals in our patients. Similar studies on co-infection and its various aspects are the need of the hour.
To Study the Role of Bone Marrow Aspiration in Etiological categorization of Pediatric Pancytopenia
Authors: Baig Mirza Asif , KB Swamy , Sharaf Fawzia , Mehmood Ibrahim , Baksh Ameen K , Moshrif Yasser , Bahashwan Ahmed , Mahajabeen Sara , El Attar Lama , Al Mutairi Nabeel , Khan Anas , Al Harbi Hajer , Multani Iqbal , Al Mutairi Nawal , Al sulami Mishal , Al Harbi Nader , Al Harbi Marwa
Published: September 2022

Background: Pancytopenia is a Clinico-hematological entity, characterized by a triad of Anemia, leucopenia, and thrombocytopenia. The criterion for defining Pancytopenia is HGB < 9 g/dl: ANC < 1.5 x 109/L and platelet count <100 x 109/L. The main objective of this study is to categorize pediatric pancytopenia’s on etiological basis and to study the age wise incidence.

Methodology and Results: This is a 5-year study (2016-2021) conducted in tertiary care pediatric referral hospital. All   data were expressed as Mean +/ - SD and p value <0.05 is taken as statistically significant. A total of 500 bone marrow smears of pancytopenic patients were studied, of which 60% were boys & 40% girls, 64% constituted Malignant diseases and 36% were benign. Incidence wise, ALL is the most common and pancytopenia being 2nd and together comprises 64% of total cases. Some rare cases like AML –M6 in 2 months old, Chediak higashi syndrome and Familial Hemophagocytic syndrome were noted. Flow cytometry and Molecular genetics were done were ever required.

Conclusion: Bone Marrow Aspiration is a reliable and sensitive test which can be used in investigation of Pediatric pancytopenia’s and if used meticulously with other routine hematological tests can give a high diagnostic accuracy. ALL is most common in our study (other studies showed Aplastic anemia), AML-M6 in 2 months, LD bodies in bone marrow, HPS were amongst the rare cases
Determination of Enterococcal Virulence Factors Expression and Impact of Biofilm Formation on Antimicrobial Susceptibility Pattern
Authors: Patel Kinjal Prashant , Mulla Summaiya
Published: September 2022

Introduction: Enterococcus spp. has become recognized as a significant cause of hospital-acquired infections. Two main virulence factors namely gelatinase and hemolysin of Enterococci have been proved to cause severe infections. In addition, biofilm formation is causing infection by enhancing the persistence of Enterococci in medical indwelling devices. Therefore, the study aimed to evaluate the presence of hemolysin, gelatinase, and biofilm formation in Enterococcus spp. and the impact of biofilm on antimicrobial susceptibility patterns.

Materials & Methods: Total 104 Enterococcal isolates obtained from different clinical samples were included in the study for expression of virulence factors. All isolates were evaluated for biofilm formation by the tissue culture plate method. Hemolysin production was checked by using 5% sheep blood agar and gelatinase production by peptone yeast extract agar containing 3% gelatin. Antimicrobial susceptibility testing was done by the Vitek2 compact automated system.

Results: Out of 104 isolates, 1(1%) were strong biofilm producers while 4(3.85% %) and 54(52%) were moderate and weak biofilm producers respectively. Hemolysin production was observed in 19(18%) isolates and gelatinase production was universal.

Conclusion: Biofilm-producing strains showed higher resistance to beta-lactam drugs and high-level aminoglycosides. Hence, amongst three virulence factors, studying biofilm formation can be an important tool to develop a hospital’s antibiotic policy and other virulence factors can be helpful to understand the pathogenesis of infection caused by Enterococcus spp. as well as for antimicrobial usage strategies.
A japán gazdasági stagnálás okainak elemzése
Authors: Tatay Blanka , Tatay Tibor
Published: September 2022

A japán gazdaság növekedése az 1990-es évek elejétől alacsony. A növekedés gyorsulását a fiskális és monetáris élénkítés sem tudta tartósan kiváltani. A tanulmány a növekedés és egyensúlytalanság problémáit mutatja be gazdaságtörténeti áttekintéssel és mutatószámokkal. Választ keres arra, hogy mely közgazdasági elméletek álltak az élénkítési kísérletek mögött. A szerzők véleménye szerint a fősodrú közgazdasági elméletek megoldásai nem voltak alkalmasak a problémák kezelésére. A japán gazdaság helyzete a szekuláris stagnálás elmélete alapján értékelhető legjobban. A gazdasági stagnálás mögött demográfiai okok kereshetők: a csökkenő létszámú és öregedő népesség.
representações sobre a pandemia nas narrativas dos jornais digitais de Porto Alegre
Authors: Morigi Valdir Jose , Milani Luciana , Campos Deise Dominique Savedra
Published: September 2022

A partir dos pressupostos teórico-metodológicos da pesquisa internacional em rede “Ciudades y comunidades imaginadas latinas en la era digital”, este artigo tem por objetivo verificar como a mídia construiu as representações sobre a pandemia de coronavírus e a cidade de Porto Alegre a partir das narrativas de jornais locais. A pesquisa foi realizada nos jornais digitais Correio do Povo, Jornal do Comércio e O Sul, no período de outubro de 2020 a dezembro de 2020. O estudo analisa às principais informações divulgadas e as imagens sobre a pandemia na cidade. As notícias sobre a pandemia privilegiaram os protocolos adotados e os impactos que a mesma trouxe para os diversos setores que envolvem a dinâmica da cidade. Conclui-se que os jornais digitais, por meio da divulgação dos conteúdos informacionais e das imagens veiculadas, exercem mediação na construção das representações sobre a pandemia na cidade.
Mediação da informação em presença
Authors: Rabello Rodrigo
Published: September 2022

Objetiva apresentar a proposição de mediação da informação “em presença” numa dimensão cosmopolítica. Para tanto, aborda contextos de mediação da informação e suas implicações para pesquisa, formação e atuação profissional no campo da ciência da informação e apresenta o alcance das associações entre atores humanos e não-humanos, evidenciando a agência de implicadores e implicados. Situa docente-pesquisador e profissional de informação como implicadores, e usuário e não-usuário de informação como implicados, em modos de mediação tradicional ou contemporâneo. Problematiza essa composição inicial ao dialogar com princípios de situacionalidade, de transitoriedade e de simetria dos atores. Com isso, delineou-se quatro situações: 1. Docente-pesquisador e profissional da informação podem implicar a dimensão cultural dos usuários e dos não-usuários; 2. Usuário de informação como implicador e profissional de informação como implicado; 3. Docente-pesquisador como implicado no ensino e na pesquisa sobre mediação da informação; e 4. Docente-pesquisador e profissional de informação implicam em e são implicados por atores não-humanos. Depreendeu-se que “estar em presença” em contextos mediacionais se torna um ponto de contato entre cosmologias. A abordagem coloca em relevo a transitoriedade nas condições de implicadores e implicados.
PERANCANGAN DESAIN MARCHANDISE SEBAGAI STRATEGI BRANDING PARIWISATA BERBASIS TRADISI LISAN DI DESA TOYOMARTO KECAMATAN SINGOSARI KABUPATEN MALANG
Authors:   Universitas Brawijaya, Rahmawati Femi Eka , Sukmawan Sony ,   Universitas Brawijaya, Syarifudin Ahmad ,   Universitas Brawijaya, Fitrahayunitisna Fitrahayunitisna ,   Universitas Brawijaya
Published: September 2022

Eksistensi dari desa wisata Toyomarto semakin meluas dengan banyaknya wisatawan yang berkunjung. Pengunjung yang datang memiliki berbagai kepentingan mulai dari yang melakukan kegiatan ritual keagamaan (spiritual) dan non-spiritual. Sebagai desa yang mencanangkan desa wisata, Toyomarto sangat perlu merumuskan citra/ identitasnya agar dapat diketahui banyak khalayak dan mempunyai posisi tawar yang lebih dibanding desa yang lainnya. Sehingga Toyomarto perlu mem-brandingkan diri agar semakin baik, maju dan berkembang. Karena itu, program pengabdian kepada masyarakat dengan tajuk “Perancangan Desain Sebagai Strategi Branding Pariwisata Berbasis Tradisi Lisan di Desa Toyomarto Kecamatan Singosari Kabupaten Malang” digagas sebagai program strategis dalam rangka membranding desa wisata Toyomarto dikalangan masyarakat luas. Secara umum, bentuk pengabdian ini dilakukan melalui pemanfaatan penelitian mengenai narasi lokal (cerita rakyat, mitos, kesenian tradisional, ungkapan tradisional) yang ada di desa Toyomarto. Narasi lokal yang ada akan secara khusus dipilih sesuai kriteria yaitu yang bersingungan dengan sumber mata air. Melalui ringkasan berbagai sumber narasi lokal tersebut akan divisualisasikan dalam bentuk desain grafis logo, desain ilustrasi, yang dapat diaplikasikan sebagai media promosi dan marchandise khas berdasarkan cerita Desa Toyomarto.
Analisis Potensi Emisi CO2 Oleh Berbagai Jenis Kendaraan Bermotor di Jalan Raya Kemantren Kabupaten Sidoarjo
Authors:   Universitas Jember, Sudarti Sudarti , Yushardi Yushardi ,   Universitas Jember, Kasanah Nur ,   Universitas Jember
Published: September 2022

Kendaraan bermotor merupakan faktor penyumbang polusi udara yang berperan tinggi. Salah satu polutan yang dihasilkan kedaraan bermotor adalah CO2, sehingga peningkatan kendaraan bermotor akan mendorong banyaknya potensi emisi CO2 dan mencemari udara. Tujuan dari penelitian ini adalah untuk menganalisis potensi emisi CO2 dari berbagai jenis kendaraan bermotor. Metode pengambilan data dilakukan dengan observasi langsung terhadap jumlah dari masing masing kendaraan bermotor selama tiga puluh menit serta studi literatur untuk mengetahui seberapa besar CO2 yang dihasilkan oleh setiap jenis kendaraan bermotor. Studi literatur yang dilakukan untuk mengetahui faktor emisi dan persamaan sesuai dengan IPCC 2006. Hasil dan pembahasan didapat dari pengambilan data (n) jumlah kendaraan bermotor kend.30 menit-1, (FE) faktor emisi g.liter-1, (K) konsumsi bahan bakar liter.km-1 dan perhitungan potensi emisi CO2. Berdasarkan pengambilan data dan perhitugan yang diperoleh menunjukkan jenis kendaraan bermotor berupa sepeda motor dan mobil ialah penyumbang terbanyak dengan potensi emisi CO2 sebesar 67,568.26 (g.30 menit-1.km-1) dan mobil sebesar 63,335.30 (g.30 menit-1.km-1).
The Sensitivity of Amphotericin B, Fluconazole, and Flusitosin to Fungal Pathogens Isolated from Wounds of Diabetic Ulcer Patients
Authors:   Farmasi, Fakultas Kedokteran Universitas Tanjungpura, Pontianak, Indonesia, Sari Rafika
Published: September 2022

A diabetic ulcer is a wound caused by infection, ulceration or destruction in people with diabetes mellitus. Mostly, diabetic ulcer found in foot. The purpose of this study was to identify pathogenic fungi in diabetic ulcers and their sensitivity to fungal drugs. The morphological determination of fungal isolates was stained with Lactophenol Cotton Blue. Determination of sensitivity using diffusion discs Kirby Bauer which are classified based on Clinical Laboratory Standard Institute (CLSI) with Amphotericin B, Fluconazole, and Flusitosin. Based on the results of the study found 8 types of pathogenic fungi namely Candida albicans (38.78%), Candida guilliermondii (4.08%), Candida kefyr 10.20%), Candida parapsilosis (10.20%), Fusarium solani (14.29) %), Microsporum audouinii (14.29%), Penicillium sp (2.04%), Trichophyton mentagrophytes (4.08%), and Trichophyton equinum (2.04%). The fungus was identified using Gideon software and the book Description of Medical Fungi. The results of the antifungal sensitivity test showed the results were sensitive to fluconazole. Amphotericin B is intermediate to Candida albicans, Candida guilliermondii, Penicillium sp. and Trichophyton sp. and is resistant to Candida kefyr and Candida parapsilosis. Flusitosin is only an intermediate against Penicillium sp. while other fungal species are immune. The conclusion of this study. The results of diabetic ulcer swabs III and IV indicate the presence of fungal colonies with species of 9 species namely Candida albicans, Candida guilliermondii, Candida kefyr, Candida Parapsilosis, Fusarium solani, Microsporum Audouinii, Penicillium sp., Trichophyton mentagrophytes, and Trichophyton equinum. Antifungal sensitivity tests on all pathogenic fungi showed sensitivity to fluconazole. Amphotericin Bintermediatrics against Candida albicans, Candida guilliermondii, Penicillium sp. and Trichophyton sp. while resistant to Candida kefyr and Candida parapsilosis. Flusitosin is only an intermediate against Penicillium sp. while other fungal species are resistant.
Insurance, Policy, Knowledge Level and Epidemiology As Factors Affecting Demand And Supply of Pharmaceutical Product
Authors:   Universitas Lambung Mangkurat, Cahaya Noor , Rachma Pramestutie Hananditia ,   Departemen Farmasi, Fakultas Kedokteran, Universitas Brawijaya, Kumala Hati Anita ,   Departemen Farmasi, Fakultas Kedokteran, Universitas Tanjung Pura, Utami Pinasti ,   Departemen farmasi Klinik dan Farmakologi, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Muhamadiyah Yogyakarta
Published: September 2022

Fulfillment of drug availability is always a challenge from year to year and is determined by supply and demand issues for pharmaceutical drugs. Good management of drugs and pharmaceutical supplies is important in health services. This is related to the quality of health services and the efficiency and effectiveness of the budget. This review study aims to examine the factors that influence drug supply and demand simultaneously with a different perspective from other studies, namely, the focus is to simultaneously discuss the effects of health insurance financing schemes, registration regulations for pharmaceutical products and imports of pharmaceutical products, the level of pharmacist knowledge, changes in disease patterns, disasters, and wars on drug supply and demand. The research design that was used in this study is a narrative review. The data sources that were used are PubMed, Science Direct, Scopus, and Google Scholar. The inclusion criteria in this study are all research related to the demand for pharmaceutical supplies and drugsthat will be reviewed in the study, either in the form of original research, reviews, or reports. The results obtained articles consisting of 8 articles related to health insurance financing, 6 articles related to registration regulation of pharmaceutical products and import of pharmaceutical products, 5 articles related to pharmacist knowledge level, 3 articles related to changes in disease patterns, and 3 articles related to disasters and wars. Based on the 25 articles that were used as data in this study, it was found that the factors that influence the supply and demand of pharmaceutical supplies are health insurance financing, regulation of registration drug processes and imports of pharmaceutical products, level of knowledge of pharmacists as pharmaceutical service providers, changes in disease patterns, disasters, politics, and war.
Potensi Senyawa Turunan Xanton dari Kulit Buah Manggis (Garcinia mangostana L.) Sebagai Inhibitor Protein Mycobacterium tuberculosis: Studi In Silico
Authors:   Program Studi Farmasi, Fakultas Farmasi, Institut Sains dan Teknologi Nasional, Jakarta, Indonesia, Maftucha Nissa , Trijuliamus Manalu Rosario ,   Program Studi Farmasi, Fakultas Farmasi, Institut Sains dan Teknologi Nasional, Jakarta, Indonesia, Amelia Rika ,   Program Studi Farmasi, Fakultas Farmasi, Institut Sains dan Teknologi Nasional, Jakarta, Indonesia, Cordia Petra ,   Program Studi Farmasi, Fakultas Farmasi, Institut Sains dan Teknologi Nasional, Jakarta, Indonesia, Bupu Regina ,   Program Studi Farmasi, Fakultas Farmasi, Institut Sains dan Teknologi Nasional, Jakarta, Indonesia
Published: September 2022

Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis infection that attacks the lungs. Tuberculosis is a dangerous disease that can cause death. In overcoming it, a safe and effective treatment is needed so that this disease can be cured. The purpose of this study was to determine the potential activity of the active compounds derived from xanthones contained in the mangosteen rind as an inhibitor of Mycobacterium tuberculosis protein with the comparison compound Isoniazid. The active compounds used in this study were α-mangostin, β-mangostin, γ-mangostin, garsinon, gartanin, and 8-deoxygartanin. This research uses the molecular docking method with Yasara, MarvinSketch, PubChem, PDB, and Plants 1.1 software. The results showed that the Gibss energy produced by each test ligand had a difference value, either lower or higher than the native ligand protein of Mycobacterium tuberculosis. Lipinski screening was done to make it easier to determine a molecule or compound based on its permeability and absorption properties. The results showed that gartanin and 8-deoxygartanin complied with Lipinski's rules. Prediction of pharmacokinetic properties and toxicity was carried out using the pkCSM website and can be concluded that gartanin and 8-deoxygartanin compounds have good pharmacokinetic properties and low toxicity.
Efektivitas Dan Keamanan Terapi dengan Rejimen Bedaquiline dalam Terapi Multidrug-Resistant Tuberculosis (TB-MDR): Kajian Sistematis
Authors:   Program Studi Magister Farmasi, Fakultas Farmasi Universitas Surabaya, Surabaya, Indonesia, Ari Kusuma Yana I Gusti Agung , Herawati Fauna ,   Pusat Informasi Obat dan Layanan Kefarmasian Universitas Surabaya (PIOLK), Fakultas Farmasi, Universitas Surabaya,  Surabaya, Indonesia
Published: September 2022

MDR-TB is a tuberculosis disease caused by Mycobacterium tuberculosis which is resistant to isoniazid and rifampin with or without resistance to other first-line drugs. The development of drug-resistant tuberculosis is causing worldwide concern. Globally in 2019, almost half a million TB sufferers of which 78% had MDR-TB. In recent years, MDR-TB patients increased by 10% from 186,883 patients in 2018 to 206,030 in 2019. Bedaquiline has been recommended by WHO guidelines. Studies related to the effectiveness and safety of Bedaquiline are still few so that there is a need for qualified information to prepare a country, especially Indonesia, for the use of Bedaquiline therapy, especially since Indonesia is ranked second out of two-thirds of the total global TB. Objective: to describe the effectiveness and safety of Bedaquiline in combination therapy for the treatment of MDR-TB. Methods: The literature search was carried out independently by researchers using the online databases of Science Direct, Pubmed, and Cochrane without restrictions on the type of research and year of publication. The keywords used in this study were combined with Boolean operators, namely “bedaquiline” AND “tuberculosis” AND “multi-drug resistant”. Results: Seven studies met the inclusion criteria, the intervention of giving Bedaquiline for 24 weeks can reduce the average time of culture conversion by about 60-85 days. The percentage of culture conversion rate was higher with Bedaquiline (range 70-85%) than placebo (58%). The most common side effects are nausea and hyperuricemia. The majority of studies report a prolongation of the QT interval in patients treated with Bedaquiline. Conclusion: This systematic review showed that Bedaquiline is effective and safe to use in the treatment of MDR-TB. However, serious side effects of QT prolongation occurred in some respondents treated with Bedaquiline. Further studies need to be conducted to monitor the side effects of QT prolongation associated with the administration of Bedaquiline in the treatment of MDR-TB.
Nutrient Composition of Red and White Cultivars of Dried Moringa oleifera Leaves from Probolinggo, Indonesia
Authors: Mudita Dhaniar , Harijono Harijono , Widjajanto Edi
Published: September 2022

Moringa oleifera is a popular plant for combating malnutrition that grows well and is commonly consumed by Indonesian as a vegetable, but local varieties' nutrient composition never was studied before. Methods: Proximate, amino acids, minerals, vitamin C, and total phenolic composition of red and white cultivars of Moringa oleifera leaves from Probolinggo were determined on a dry weight basis based on AOAC methods. Results: Crude protein and fat were higher in white cultivar (35.36%, 6.25%). Total Amino Acid in both cultivars (83.06 g/100g for red and 82.86g/100g for white) were higher than in previous studies. Total Essential Amino Acid (TEAA) percentage of both of the cultivars was 46-49% and met the ideal protein needs of children (26%) and adults (11%). Iron, Zinc, Copper, Calcium, and Manganese was higher in white cultivar (36.21±0.08 mg/kg, 16.32±0.02%, 6.76±0.08mg/kg, 1.56±0.00 mg/kg, 7.11±0.00 mg/kg), while Magnesium, Potassium, Sodium, Phosphorus was higher in red cultivar (0.61±0.00%, 0.89±0.00%, 0.65±0.00%, 0.99±0.00). The content of vitamin C and total phenols was higher in the red cultivar (4162.8mg/kg and 239.8mg/kg). Conclusions: The red cultivar were best in 10/22 parameters (45%), white cultivar was best in 14/22 (55%). Those characteristics can contribute significantly to the nutrient requirements for protein and energy malnutrition treatment.
Guia de comunicação em saúde. Áreas especializadas
Authors: Duarte Melo Ana G. S. , Ruão Teresa , Balonas Sara , Alves Marta , Ferreira Marta
Published: September 2022

A comunicação de saúde tem vindo a adquirir um grau cada vez maior de especialização e muitas das necessidades de comunicação identificadas pelos profissionais de saúde e pelos stakeholders do PNS 2021-2030 convocam um conhecimento específico que tratamos de explorar aqui. Abordam-se áreas muito diversas desde a comunicação organizacional à comunicação que visa envolver e mobilizar a comunidade, da comunicação participativa à comunicação para a mudança comportamental, bem como a comunicação de crise e a comunicação com os média.
Play and learning in early childhood education: tensions and challenges
Authors: Wood Elizabeth Ann
Published: September 2022

International research promotes the value of play for children’s learning and development. However, in early childhood education the development of national policy frameworks highlights a tension, and possible contradiction, between play for its own sake, and educational play. This paper explores these two positions, drawing on contemporary socio-cultural theories. Freely chosen play reflects children’s choices, interests and inquiries, and is understood as complex socio-cultural activity. Educational play focuses on curriculum goals and outcomes, and requires early childhood educators to plan for play in ways that direct children’s learning towards those goals. Recent research on children’s interests and inquiries offers solutions for pedagogical approaches that connect the curriculum as lived experiences, and curriculum as planned experiences, both of which reflect children’s cultural repertoires and peer cultures.
Reinterpretation of Health Information in the Context of an Emerging Infectious Disease: A Digital Focus Group Study
Authors: Tan Rayner Kay Jin , Lim Jane Mingjie , Neo Pearlyn Hui Min , Ong Suan Ee
Published: September 2022

Background

Misinformation related to the COVID-19 pandemic has accelerated global public concern and panic. The glut of information, or “infodemic,” has caused concern for authorities due to its negative impacts on COVID-19 prevention and control, spurring calls for a greater scholarly focus on health literacy during the pandemic. Nevertheless, few studies have sought to qualitatively examine how individuals interpreted and assimilated health information at the initial wave of COVID-19 restrictions.

Objective

We developed this qualitative study adopting chat-based focus group discussions to investigate how individuals interpreted COVID-19 health information during the first wave of COVID-19 restrictions.

Methods

We conducted a qualitative study in Singapore to investigate how individuals perceive and interpret information that they receive on COVID-19. Data were generated through online focus group discussions conducted on the mobile messaging smartphone app WhatsApp. From March 28 to April 13, 2020, we held eight WhatsApp-based focus groups (N=60) with participants stratified by age groups, namely 21-30 years, 31-40 years, 41-50 years, and 51 years and above. Data were thematically analyzed.

Results

A total of four types of COVID-19 health information were generated from the thematic analysis, labeled as formal health information, informal health information, suspicious health information, and fake health information, respectively. How participants interpreted these categories of information depended largely on the perceived trustworthiness of the information source as well as the perceived veracity of information. Both factors were instrumental in determining individuals’ perceptions, and their subsequent treatment and assimilation of COVID-19–related information.

Conclusions

Both perceived trustworthiness of the information source and perceived veracity of information were instrumental concepts in determining one’s perception, and thus subsequent treatment and assimilation of such information for one’s knowledge of COVID-19 or the onward propagation to their social networks. These findings have implications for how policymakers and health authorities communicate with the public and deal with fake health information in the context of COVID-19.
Health Information From Web Search Engines and Virtual Assistants About Pre-Exposure Prophylaxis for HIV Prevention in Adolescents and Young Adults: Content Analysis (Preprint)
Authors: Darien Kaja , Lee Susan , Knowles Kayla , Wood Sarah , Langer Miriam D , Lazar Nellie , Dowshen Nadia
Published: September 2022

BACKGROUND

Adolescents and young adults are disproportionately affected by HIV, suggesting that HIV prevention methods such as pre-exposure prophylaxis (PrEP) should focus on this group as a priority. As digital natives, youth likely turn to internet resources regarding health topics they may not feel comfortable discussing with their medical providers. To optimize informed decision-making by adolescents and young adults most impacted by HIV, the information from internet searches should be educational, accurate, and readable.

OBJECTIVE

The aims of this study were to compare the accuracy of web-based PrEP information found using web search engines and virtual assistants, and to assess the readability of the resulting information.

METHODS

Adolescent HIV prevention clinical experts developed a list of 23 prevention-related questions that were posed to search engines (Ask.com, Bing, Google, and Yahoo) and virtual assistants (Amazon Alexa, Microsoft Cortana, Google Assistant, and Apple Siri). The first three results from search engines and virtual assistant web references, as well as virtual assistant verbal responses, were recorded and coded using a six-tier scale to assess the quality of information produced. The results were also entered in a web-based tool determining readability using the Flesch-Kincaid Grade Level scale.

RESULTS

Google web search engine and Google Assistant more frequently produced PrEP information of higher quality than the other search engines and virtual assistants with scores ranging from 3.4 to 3.7 and 2.8 to 3.3, respectively. Additionally, the resulting information generally was presented in language at a seventh and 10th grade reading level according to the Flesch-Kincaid Grade Level scale.

CONCLUSIONS

Adolescents and young adults are large consumers of technology and may experience discomfort discussing their sexual health with providers. It is important that efforts are made to ensure the information they receive about HIV prevention methods, and PrEP in particular, is comprehensive, comprehensible, and widely available.
Indications for and Timing of Initiation of KRT
Authors: Ostermann Marlies , Bagshaw Sean M. , Lumlertgul Nuttha , Wald Ron
Published: September 2022

KRT is considered for patients with severe AKI and associated complications. The exact indications for initiating KRT have been debated for decades. There is a general consensus that KRT should be considered in patients with AKI and medically refractory complications (“urgent indications”). “Relative indications” are more common but defined with less precision. In this review, we summarize the latest evidence from recent landmark clinical trials, discuss strategies to anticipate the need for KRT in individual patients, and propose an algorithm for decision making. We emphasize that the decision to consider KRT should be made in conjunction with other forms of organ support therapies and important nonkidney factors, including the patient’s preferences and overall goals of care. We also suggest future research to differentiate patients who benefit from timely initiation of KRT from those with imminent recovery of kidney function. Until then, efforts are needed to optimize the initiation and delivery of KRT in routine clinical practice, to minimize nonessential variation, and to ensure that patients with persistent AKI or progressive organ failure affected by AKI receive KRT in a timely manner.
Maternal mortality associated with COVID-19: An integrative literature review
Authors: Gois Lucas Costa de , Silva Sabrina Brenda Castelo Branco , Oliveira Ana Emília Araújo de , Flor Ananda Karina Meneses , Pereira Débora Lorena Melo , Maslinkiewicz Alexandre , Silva Julianne de Area Leão Pereira da , Reis Alan Jefferson Alves , Pôrto Stéfano Vasconcelos , Nunes Thaís Gonçalves , Galvão Fábio Freitas de Sousa Passos , Sá Bruna Victoria de Sousa , Sales Andresa de Araújo , fontinele Vanessa carvalho , Araujo Gabriel Gardhel Costa , Taumaturgo Idna de Carvalho Barros
Published: September 2022

COVID-19 is a respiratory disease caused by the SARS-CoV-2 virus that, in severe cases, progresses with extremely clinically relevant complications, directly impacting the morbidity and mortality of the population. The disease was first discovered in Wuhan, China, in December 2019. Thus, the studies were published in the years 2020, 2021 and 2022, being the equivalent of 41.67% in the year 2020, 50.00% in the year 2021 and about 8.33% in the year 2022. Therefore, most of the jobs were from Mexico with 33.33%, against 25.00% from Iran, 16.67% in Brazil, 16.67 % in the United States and 8.33% in Italy. In view of the exposed results, it was highlighted that the infection by COVID-19 in pregnant women negatively affected maternal health, being responsible for maternal injuries and/or death. Some epidemiological and clinical risk factors were associated with negative outcomes, as well as barriers to accessing health care.
Aspects between Dengue and COVID-19 coinfection: An integrative literature review
Authors: Gois Lucas Costa de , Silva Sabrina Brenda Castelo Branco , Araújo Glória Stéphany Silva de , Oliveira Kathllyn Joyce de Jesus , Sá Bruna Victoria de Sousa , Damasceno Stálin Santos , Maslinkiewicz Alexandre , Silva Julianne de Area Leão Pereira da , Pôrto Stéfano Vasconcelos , Filho Jean Carlos Leal Carvalho de Melo , Dias Júlio César Cardozo , Silva Kleiton Vieira da , Nascimento Rômulo Gueth Borges do , Miranda Maria Clara Leite Barros , Souza Lizandra Ellem Silva de , Araujo Gabriel Gardhel Costa , Taumaturgo Idna de Carvalho Barros
Published: September 2022

The disease caused by the new coronavirus (COVID-19), initially investigated in the city of Wuhan, located in China, during 2019 later spread worldwide, affecting millions of individuals, therefore, it triggered the pandemic event, perpetuated with consequences in areas population and economic. However, Dengue is an arboviral pathology with endemic proportions in tropical areas, spread through Aedes aegypti because it spreads the infectious agent. Therefore, the clinical picture emerges that culminates in an increase in body temperature, bleeding events, cephalalgia or pruritus. Thus, the studies were published in the years 2020 to 2021, being the equivalent of 36.36% in the year 2020, and about 63.64% in the year 2021. In this way, the contents of the research found referred to Aspects between Dengue and COVID-19 coinfection. Both have similar clinical manifestations, so their main difference is the respiratory compromise that is more evident in COVID-19.
Centrales maxilares impactados asociados a supernumerarios manejo ortodóntico con anclaje de tipo dental
Authors: Vera Castellanos Sindy Katerine , Gurrola Martínez Beatriz , Casasa Araujo Adán
Published: September 2022

Una de las complicaciones orales de los dientes supernumerarios es la impactación de los dientes adyacentes, entre otras, el apiñamiento, la formación de diastema, la rotación, el desplazamiento de los dientes, interferencia oclusal, caries, problemas periodontales, dificultad en la masticación y estética comprometida, la asociación con supernumerarios múltiples, la formación de un quiste dentígero con destrucción ósea, reabsorción radicular y fístula oronasal. Se presenta el manejo de un paciente de 11 años de edad diagnosticado como clase II esquelética con crecimiento normodivergente, clase I molar bilateral y clase II canina bilateral, con los órganos dentales 11 y 21 retenidos, mordida cruzada posterior derecha, apiñamiento inferior, presencia de dientes supernumerarios sin erupcionar entre canino y premolar así como sector anterosuperior. Para el tratamiento se realizó la alineación, nivelación, extracción de dientes supernumerarios, cirugía para la tracción de los incisivos centrales, stripping. En el detallado y retención se utilizaron: brackets prescripción Roth 0.022" × 0.028", tubos bondeables en 6's y 7's superiores, bandas con tubos punteables en 6's en botones en órganos dentales 11 y 21 bondeables en 6's y 7's superiores. Tiempo de tratamiento activo un año y seis meses. La retención Hawley con cinturón vestibular superior e inferior.
Development of DSP-Based Transmission Line Fault Detection
Authors: Sawale Monali A. , Dongre Dr. Kiran
Published: September 2022

Abstract: This paper proposes a new algorithm to detect and classify faults in the electric power transmission line. Transmission line protection is an important issue in power system engineering because 85-87% of power system faults are occurring in transmission lines. This paper presents a technique to detect and classify the different shunt faults on transmission lines for quick and reliable operation of protection schemes. Discrimination among different types of faults on the transmission lines is achieved by the application of evolutionary programming tools. Further, fault signal data are imported into MATLAB for postprocessing, and time-frequency analysis using Signal Processing Toolbox in MATLAB.
Customer Satisfaction: An Insight Towards E-Commerce
Authors: M Likhitha
Published: September 2022

Today the world is becoming digital in every part. The internet-services are charming with ‘popularity’ (fame) and the vital facet for the communication growth technologies are creating (making) a very fast improvement. Every year National Technology Day is celebrated on May 11 and this year theme is 'An Integrated Approach to Science and Technology for a Sustainable Future'. As Technology is substituting the phase of traditional methods of buying and selling in terms of online ecommerce. Now-a-days folks choose to purchase or shop the products (goods) by just 1 click (one single click), by via gadgets. E--commerce firms provide extreme service quality to the users or customers, and also preserve trust of users (customers) and satisfaction. Website value is ‘central-objective’ for acquiring customer satisfaction and e-commerce website triumph. Based on TAM (total addressable market) model, let us analyse the effect of customer satisfaction. Website quality may consist of three dimensions: system quality, service quality and information quality.
Bermain origami untuk melatih keterampilan motorik halus anak usia dini
Authors: Sandra Adetya  , Gina Fathana
Published: September 2022

The development of fine motor skills in children age 2-12 years old is important because it is related to other developmental tasks, such as independence, cognitive abilities, etc. In fact, not many parents have sufficient knowledge of aspects of child development and how to develop it. The program that will be carried out in community service is playing origami to practice fine motor skills. The community service partner is Sekolah Rakyat Bekasi, a community formed by student volunteers who care about the development and education of underprivileged children living on the river banks in the Teluk Buyung area, Bekasi Utara. The purpose of playing origami in particular is to provide the experience of playing origami and provide the experience of playing origami and provide stimulation to enhance fine motor skills in children at Sekolah Rakyat Bekasi. There are 30 children who joined the program. The results of the service activity showed that the children succeeded in folding origami according to the instructions given, and participants benefited from playing with origami, including practicing fine motor skills and concentration.
The Effect of Contractor Brand on Apartment Presale Price and Investment Return: Focusing on U-dong, Haeundae-gu, Busan
Authors:   Residential Environment Institute Of Korea, Lee Yong-Hyok , Shin Seung-Woo
Published: September 2022

Depending on the economic situation, real estate policies have been announced with the goal of stabilizing real estate or revitalizing the economy. Before implementing real estate policies, effective operation and evaluation of government policies are essential.
Real estate exhibits different regional variations due to its unique location fixity, and as a consumer and investment good, it is a commodity that is affected in a complex way, such as liquidity, supply, macroeconomics, and psychology. Real estate policies vary by tax policies such as holding tax and capital gains tax, and housing finance regulations (LTV, DTI). From this point of view, there is a need for a tool that can analyze the comprehensive policy effects including various types of real estate policies of the government.
In this study, the available variables among the macroeconomic variables of the real estate market macroeconomic model designed on the premise of the ripple path following the implementation of real estate policies and the apartment sales transaction price index in the metropolitan area and nationwide, which is a proxy for apartment houses, were set as variables and analyzed through multivariate analysis. Analyze dynamic variations between variables. The purpose of this study is to examine the effect of housing finance regulation on housing mortgage loans in the national and metropolitan areas among real estate policies and the effect of tax policies and mortgage loans on apartment house prices (apartment sale price index) among real estate policies. We would like to focus on analyzing the effectiveness of the policy.