bluuebunny/crossref_metadata_2025 huggingface dataset:
An all-dielectric metasurface as a broadband optical frequency mixer
Authors: Liu Sheng , Vabishchevich Polina P. , Vaskin Aleksandr , Reno John L. , Keeler Gordon A. , Sinclair Michael B. , Staude Isabelle , Brener Igal
Published: June 2018

A frequency mixer is a nonlinear device that combines electromagnetic waves to create waves at new frequencies. Mixers are ubiquitous components in modern radio-frequency technology and microwave signal processing. The development of versatile frequency mixers for optical frequencies remains challenging: such devices generally rely on weak nonlinear optical processes and, thus, must satisfy phase-matching conditions. Here we utilize a GaAs-based dielectric metasurface to demonstrate an optical frequency mixer that concurrently generates eleven new frequencies spanning the ultraviolet to near-infrared. The even and odd order nonlinearities of GaAs enable our observation of second-harmonic, third-harmonic, and fourth-harmonic generation, sum-frequency generation, two-photon absorption-induced photoluminescence, four-wave mixing and six-wave mixing. The simultaneous occurrence of these seven nonlinear processes is assisted by the combined effects of strong intrinsic material nonlinearities, enhanced electromagnetic fields, and relaxed phase-matching requirements. Such ultracompact optical mixers may enable a plethora of applications in biology, chemistry, sensing, communications, and quantum optics.
Excited-state vibrational dynamics toward the polaron in methylammonium lead iodide perovskite
Authors: Park Myeongkee , Neukirch Amanda J. , Reyes-Lillo Sebastian E. , Lai Minliang , Ellis Scott R. , Dietze Daniel , Neaton Jeffrey B. , Yang Peidong , Tretiak Sergei , Mathies Richard A.
Published: June 2018

Hybrid organic–inorganic perovskites have attractive optoelectronic properties including exceptional solar cell performance. The improved properties of perovskites have been attributed to polaronic effects involving stabilization of localized charge character by structural deformations and polarizations. Here we examine the Pb–I structural dynamics leading to polaron formation in methylammonium lead iodide perovskite by transient absorption, time-domain Raman spectroscopy, and density functional theory. Methylammonium lead iodide perovskite exhibits excited-state coherent nuclear wave packets oscillating at ~20, ~43, and ~75 cm−1 which involve skeletal bending, in-plane bending, and c-axis stretching of the I–Pb–I bonds, respectively. The amplitudes of these wave packet motions report on the magnitude of the excited-state structural changes, in particular, the formation of a bent and elongated octahedral PbI64− geometry. We have predicted the excited-state geometry and structural changes between the neutral and polaron states using a normal-mode projection method, which supports and rationalizes the experimental results. This study reveals the polaron formation via nuclear dynamics that may be important for efficient charge separation.
Doping-induced structural phase transition in cobalt diselenide enables enhanced hydrogen evolution catalysis
Authors: Zheng Ya-Rong , Wu Ping , Gao Min-Rui , Zhang Xiao-Long , Gao Fei-Yue , Ju Huan-Xin , Wu Rui , Gao Qiang , You Rui , Huang Wei-Xin , Liu Shou-Jie , Hu Shan-Wei , Zhu Junfa , Li Zhenyu , Yu Shu-Hong
Published: June 2018

Transition metal dichalcogenide materials have been explored extensively as catalysts to negotiate the hydrogen evolution reaction, but they often run at a large excess thermodynamic cost. Although activating strategies, such as defects and composition engineering, have led to remarkable activity gains, there remains the requirement for better performance that aims for real device applications. We report here a phosphorus-doping-induced phase transition from cubic to orthorhombic phases in CoSe2. It has been found that the achieved orthorhombic CoSe2 with appropriate phosphorus dopant (8 wt%) needs the lowest overpotential of 104 mV at 10 mA cm−2 in 1 M KOH, with onset potential as small as −31 mV. This catalyst demonstrates negligible activity decay after 20 h of operation. The striking catalysis performance can be attributed to the favorable electronic structure and local coordination environment created by this doping-induced structural phase transition strategy.
Long-haul optical transmission link using low-noise phase-sensitive amplifiers
Authors: Olsson Samuel L.I. , Eliasson Henrik , Astra Egon , Karlsson Magnus , Andrekson Peter A.
Published: June 2018

The capacity and reach of long-haul fiber optical communication systems is limited by in-line amplifier noise and fiber nonlinearities. Phase-sensitive amplifiers add 6 dB less noise than conventional phase-insensitive amplifiers, such as erbium-doped fiber amplifiers, and they can provide nonlinearity mitigation after each span. Realizing a long-haul transmission link with in-line phase-sensitive amplifiers providing simultaneous low-noise amplification and nonlinearity mitigation is challenging and to date no such transmission link has been demonstrated. Here, we demonstrate a multi-channel-compatible and modulation-format-independent long-haul transmission link with in-line phase-sensitive amplifiers. Compared to a link amplified by conventional erbium-doped fiber amplifiers, we demonstrate a reach improvement of 5.6 times at optimal launch powers with the phase-sensitively amplified link operating at a total accumulated nonlinear phase shift of 6.2 rad. The phase-sensitively amplified link transmits two data-carrying waves, thus occupying twice the bandwidth and propagating twice the total power compared to the phase-insensitively amplified link.
Designing a magnesium alloy with high strength and high formability
Authors: Trang T. T. T. , Zhang J. H. , Kim J. H. , Zargaran A. , Hwang J. H. , Suh B.-C. , Kim N. J.
Published: June 2018

Although magnesium alloys, as the lightest structural alloys, offer significant potential for automotive applications, their applications remain limited due to their poor formability at room temperature. Since the strategies used for improving formability usually result in a degradation of strength, there are no high strength magnesium alloys showing good formability. Here we report an alloy design concept that can simultaneously provide high strength and good formability. Such designed alloy when subjected to an appropriate processing technique shows a combination of strength and formability that surpasses those of the existing magnesium alloys reported so far. The alloy design concept used in the present study is based on the utilization of alloying elements that can induce precipitation, as well as maximize the segregation of other texture-controlling alloying elements. Such developed alloy is expected to broaden the application of Mg alloy sheets, which are now starting to gain acceptance by automotive industries.
Possible nitrogen fertilization of the early Earth Ocean by microbial continental ecosystems
Authors: Thomazo Christophe , Couradeau Estelle , Garcia-Pichel Ferran
Published: June 2018

While significant efforts have been invested in reconstructing the early evolution of the Earth’s atmosphere–ocean–biosphere biogeochemical nitrogen cycle, the potential role of an early continental contribution by a terrestrial, microbial phototrophic biosphere has been largely overlooked. By transposing to the Archean nitrogen fluxes of modern topsoil communities known as biological soil crusts (terrestrial analogs of microbial mats), whose ancestors might have existed as far back as 3.2 Ga ago, we show that they could have impacted the evolution of the nitrogen cycle early on. We calculate that the net output of inorganic nitrogen reaching the Precambrian hydrogeological system could have been of the same order of magnitude as that of modern continents for a range of inhabited area as small as a few percent of that of present day continents. This contradicts the assumption that before the Great Oxidation Event, marine and continental biogeochemical nitrogen cycles were disconnected.
Change in longitudinal trends in sleep quality and duration following breast cancer diagnosis: results from the Women’s Health Initiative
Authors: Beverly Chloe M. , Naughton Michelle J. , Pennell Michael L. , Foraker Randi E. , Young Gregory , Hale Lauren , Feliciano Elizabeth M. Cespedes , Pan Kathy , Crane Tracy E. , Danhauer Suzanne C. , Paskett Electra D.
Published: June 2018

Breast cancer survivors frequently report sleep problems, but little research has studied sleep patterns longitudinally. We examined trends in sleep quality and duration up to 15 years before and 20 years after a diagnosis of breast cancer, over time among postmenopausal women participating in the Women’s Health Initiative (WHI). We included 12,098 participants who developed invasive breast cancer after study enrollment. A linear mixed-effects model was used to determine whether the time trend in sleep quality, as measured by the WHI Insomnia Rating Scale (WHIIRS), a measure of perceived insomnia symptoms from the past 4 weeks, changed following a cancer diagnosis. To examine sleep duration, we fit a logistic regression model with random effects for both short (<6 h) and long (≥9 h) sleep. In addition, we studied the association between depressive symptoms and changes in WHIIRS and sleep duration. There was a significantly slower increase in the trend of WHIIRS after diagnosis (β = 0.06; p = 0.03), but there were non-significant increases in the trend of the probability of short or long sleep after diagnosis. The probability of depressive symptoms significantly decreased, though the decrease was more pronounced after diagnosis (p < 0.01). Trends in WHIIRS worsened at a relatively slower rate following diagnosis and lower depression rates may explain the slower worsening in WHIIRS. Our findings suggest that over a long period of time, breast cancer diagnosis does not adversely affect sleep quality and duration in postmenopausal women compared to sleep pre-diagnosis, yet both sleep quality and duration continue to worsen over time.
Nanostructure, structural stability, and diffusion characteristics of layered coatings for heat-assisted magnetic recording head media
Authors: Matlak J. , Rismaniyazdi E. , Komvopoulos K.
Published: June 2018

The intense laser heating in heat-assisted magnetic recording (HAMR) has been a major hindrance to HAMR technology from becoming commercially viable. Thermal damage of the near-field transducer (NFT) and write pole (WP) embedded in the trailing edge of the magnetic head due to failure of the protective carbon overcoat after prolonged heating at an elevated temperature are major obstacles. Therefore, the main objective of this study was to develop an effective coating method for HAMR heads. This was accomplished by introducing a new class of layered coatings consisting of ultrathin amorphous carbon (a-C) overcoat, adhesion (SiN) layer, and buffer (NiCr or TaOx) layer sequentially deposited onto Au and FeCo base layers to mimic the layer stacking of NFT and WP elements, respectively. The structural stability of the a-C overcoats and diffusion characteristics of each comprising layer under conditions of heating at 350 °C for 30 min in an Ar atmosphere were investigated by high-resolution transmission electron microscopy (HRTEM), scanning transmission electron microscopy (STEM), and electron energy loss spectroscopy (EELS). For most stacking configurations the HRTEM/STEM and EELS results generally revealed some layer intermixing and minute carbon atom rehybridization in the heated a-C overcoats. The findings of this investigation suggest that further optimization of the developed layered coatings can provide a viable solution to thermal damage of HAMR heads.
Normal Mode Splitting in a Moving-Particles-Pumped Mechanical Oscillator: Clamped-Hinged Homogeneous Beam
Authors: Sun Zhi
Published: June 2018

The interaction of a mechanical oscillator with the operation actions and environment fields will give rise to the splitting of normal modes. In this study, we investigate the normal mode splitting behaviour of a moving-particles-pumped single-span clamped-hinged elastic homogeneous beam based on the proposed multi-octave modal parametric oscillation model. Numerical experiments show the entangled and squeezed oscillations of the phase-conjugated waves near the resonance tongues. Theoretical analysis predicts the occurrence of multiple simple resonances and the squeezing of the twin waves modal oscillation in the region with a low speed of movement for the studied system.
7B2 chaperone knockout in APP model mice results in reduced plaque burden
Authors: Jarvela Timothy S. , Womack Tasha , Georgiou Polymnia , Gould Todd D. , Eriksen Jason L. , Lindberg Iris
Published: June 2018

Impairment of neuronal proteostasis is a hallmark of Alzheimer’s and other neurodegenerative diseases. However, the underlying molecular mechanisms leading to pathogenic protein aggregation, and the role of secretory chaperone proteins in this process, are poorly understood. We have previously shown that the neural-and endocrine-specific secretory chaperone 7B2 potently blocks in vitro fibrillation of Aβ42. To determine whether 7B2 can function as a chaperone in vivo, we measured plaque formation and performed behavioral assays in 7B2-deficient mice in an hAPPswe/PS1dE9 Alzheimer’s model mouse background. Surprisingly, immunocytochemical analysis of cortical levels of thioflavin S- and Aβ-reactive plaques showed that APP mice with a partial or complete lack of 7B2 expression exhibited a significantly lower number and burden of thioflavin S-reactive, as well as Aβ-immunoreactive, plaques. However, 7B2 knockout did not affect total brain levels of either soluble or insoluble Aβ. While hAPP model mice performed poorly in the Morris water maze, their brain 7B2 levels did not impact performance. Since 7B2 loss reduced amyloid plaque burden, we conclude that brain 7B2 can impact Aβ disposition in a manner that facilitates plaque formation. These results are reminiscent of prior findings in hAPP model mice lacking the ubiquitous secretory chaperone clusterin.
Motility and chemotaxis of bacteria-driven microswimmers fabricated using antigen 43-mediated biotin display
Authors: Schauer Oliver , Mostaghaci Babak , Colin Remy , Hürtgen Daniel , Kraus David , Sitti Metin , Sourjik Victor
Published: June 2018

Bacteria-driven biohybrid microswimmers (bacteriabots) combine synthetic cargo with motile living bacteria that enable propulsion and steering. Although fabrication and potential use of such bacteriabots have attracted much attention, existing methods of fabrication require an extensive sample preparation that can drastically decrease the viability and motility of bacteria. Moreover, chemotactic behavior of bacteriabots in a liquid medium with chemical gradients has remained largely unclear. To overcome these shortcomings, we designed Escherichia coli to autonomously display biotin on its cell surface via the engineered autotransporter antigen 43 and thus to bind streptavidin-coated cargo. We show that the cargo attachment to these bacteria is greatly enhanced by motility and occurs predominantly at the cell poles, which is greatly beneficial for the fabrication of motile bacteriabots. We further performed a systemic study to understand and optimize the ability of these bacteriabots to follow chemical gradients. We demonstrate that the chemotaxis of bacteriabots is primarily limited by the cargo-dependent reduction of swimming speed and show that the fabrication of bacteriabots using elongated E. coli cells can be used to overcome this limitation.
Kinked silicon nanowires-enabled interweaving electrode configuration for lithium-ion batteries
Authors: Sandu Georgiana , Coulombier Michael , Kumar Vishank , Kassa Hailu G. , Avram Ionel , Ye Ran , Stopin Antoine , Bonifazi Davide , Gohy Jean-François , Leclère Philippe , Gonze Xavier , Pardoen Thomas , Vlad Alexandru , Melinte Sorin
Published: June 2018

A tri-dimensional interweaving kinked silicon nanowires (k-SiNWs) assembly, with a Ni current collector co-integrated, is evaluated as electrode configuration for lithium ion batteries. The large-scale fabrication of k-SiNWs is based on a procedure for continuous metal assisted chemical etching of Si, supported by a chemical peeling step that enables the reuse of the Si substrate. The kinks are triggered by a simple, repetitive etch-quench sequence in a HF and H2O2-based etchant. We find that the inter-locking frameworks of k-SiNWs and multi-walled carbon nanotubes exhibit beneficial mechanical properties with a foam-like behavior amplified by the kinks and a suitable porosity for a minimal electrode deformation upon Li insertion. In addition, ionic liquid electrolyte systems associated with the integrated Ni current collector repress the detrimental effects related to the Si-Li alloying reaction, enabling high cycling stability with 80% capacity retention (1695 mAh/gSi) after 100 cycles. Areal capacities of 2.42 mAh/cm2 (1276 mAh/gelectrode) can be achieved at the maximum evaluated thickness (corresponding to 1.3 mgSi/cm2). This work emphasizes the versatility of the metal assisted chemical etching for the synthesis of advanced Si nanostructures for high performance lithium ion battery electrodes.
Sample-to-Answer Droplet Magnetofluidic Platform for Point-of-Care Hepatitis C Viral Load Quantitation
Authors: Shin Dong Jin , Trick Alexander Y. , Hsieh Yu-Hsiang , Thomas David L. , Wang Tza-Huei
Published: June 2018

Gold standard quantitative nucleic acid tests for diagnosis of viral diseases are currently limited to implementation in laboratories outside of the clinic. An instrument for conducting nucleic acid testing at the point-of-care (POC) that is easily operable by the clinician would reduce the required number of visits to the clinic and improve patient retention for proper treatment. Here we present a droplet magnetofluidic (DM) platform, which leverages functionalized magnetic particles to miniaturize and automate laboratory assays for use in the clinic at the POC. Our novel thermoformed disposable cartridge coupled to a portable multiaxial magnetofluidic instrument enables real-time PCR assays for quantitative and sensitive detection of nucleic acids from crude biosamples. Instead of laborious benchtop sample purification techniques followed by elution and spiking into PCR buffer, the user simply injects the biosample of interest into a cartridge with magnetic particles and loads the cartridge into the instrument. We demonstrate the utility of our platform with hepatitis C virus (HCV) RNA viral load quantitation from blood serum in approximately 1 hour. Clinical serum samples (n = 18) were directly processed on cartridges with no false positives and a limit of detection of 45 IU per 10 µl sample injection.
Changes in gene expression in Camelina sativa roots and vegetative tissues in response to salinity stress
Authors: Heydarian Zohreh , Yu Min , Gruber Margaret , Coutu Cathy , Robinson Stephen J. , Hegedus Dwayne D.
Published: June 2018

The response of Camelina sativa to salt stress was examined. Salt reduced shoot, but not root length. Root and shoot weight were affected by salt, as was photosynthetic capacity. Salt did not alter micro-element concentration in shoots, but increased macro-element (Ca and Mg) levels. Gene expression patterns in shoots indicated that salt stress may have led to shuttling of Na+ from the cytoplasm to the tonoplast and to an increase in K+ and Ca+2 import into the cytoplasm. In roots, gene expression patterns indicated that Na+ was exported from the cytoplasm by the SOS pathway and that K+ was imported in response to salt. Genes involved in chelation and storage were up-regulated in shoots, while metal detoxification appeared to involve various export mechanisms in roots. In shoots, genes involved in secondary metabolism leading to lignin, anthocyanin and wax production were up-regulated. Partial genome partitioning was observed in roots and shoots based on the expression of homeologous genes from the three C. sativa sub-genomes. Sub-genome I and II were involved in the response to salinity stress to about the same degree, while about 10% more differentially-expressed genes were associated with sub-genome III.
Recent examples of α-ketoglutarate-dependent mononuclear non-haem iron enzymes in natural product biosyntheses
Authors: Gao Shu-Shan , Naowarojna Nathchar , Cheng Ronghai , Liu Xueting , Liu Pinghua
Published: June 2018

Proximal- and distal-type αKG binding to the Fe(ii) centre might play a crucial role in fine-tuning the catalysis of αKG-dependent non-haem iron enzymes.
Probing the propeller-like loops of DNA G-quadruplexes with looped-out 2-aminopurine for label-free switchable molecular sensing
Authors: Peng Pai , Du Yi , Sun Yudie , Liu Shuangna , Mi Lan , Li Tao
Published: June 2018

We report a novel ligand-free signal readout mechanism for probing the propeller-like loops of DNA G-quadruplexes with looped-out 2-aminopurine.
Visible-light induced three-component alkynyl-difluoroalkylation of unactivated alkenes
Authors: Jin Weiwei , Wu Mingchang , Xiong Zhimin , Zhu Gangguo
Published: June 2018

A visible-light induced three-component alkynyl-fluoroalkylation of unactivated alkenes is described, giving a facile access to β-fluoroalkylated alkynes under room temperature conditions.
Chiral modulation of amyloid beta fibrillation and cytotoxicity by enantiomeric carbon dots
Authors: Malishev Ravit , Arad Elad , Bhunia Susanta Kumar , Shaham-Niv Shira , Kolusheva Sofiya , Gazit Ehud , Jelinek Raz
Published: June 2018

Enantiomeric carbon dots (C-dots) synthesized from l-lysine or d-lysine, modulate aggregation and cytotoxicity of amyloid beta-42 (Aβ42), the primary constituent of the amyloid plaques associated with Alzheimer's disease.
Orthogonal reactivity of Ni(i)/Pd(0) dual catalysts for Ullmann C–C cross-coupling: theoretical insight
Authors: Zhu Bo , Yan Li-Kai , Yao Li-Shuang , Ren Hang , Li Run-Han , Guan Wei , Su Zhong-Min
Published: June 2018

The orthogonal reactivity of nickel(i)/palladium(0) has been illuminated to be the precondition and foundation of achieving Ullmann C–C cross-coupling.
Fusing triphenylphosphine with tetraphenylborate: introducing the 9-phosphatriptycene-10-phenylborate (PTB) anion
Authors: Drover Marcus W. , Nagata Koichi , Peters Jonas C.
Published: June 2018

In a fusion of two ubiquitous organometallic reagents, triphenylphosphine (PPh3) and tetraphenylborate (BPh4−), the 9-phosphatriptycene-10-phenylborate (PTB) anion has been prepared for the first time.
Supramolecular chemotherapeutic drug constructed from pillararene-based supramolecular amphiphile
Authors: Wu Dan , Li Yang , Shen Jie , Tong Zaizai , Hu Qinglian , Li Liping , Yu Guocan
Published: June 2018

A therapeutic supramolecular amphiphile, P5⊃CPT-ss-Py, with GSH-responsiveness was constructed using pillar[5]arene-based host–guest molecular recognition. Cellular internalization and anticancer efficacy were greatly increased through this supramolecular strategy.
A two-fold interpenetrated zinc–organic framework: luminescence detection of CrO42−/Cr2O72− and chemical conversion of CO2
Authors: Shi Ying , Song Tian-Qun , Cao Chun-Shuai , Zhao Bin
Published: June 2018

A novel two-fold interpenetrated 3D framework can adsorb CO2 and serve as an efficient and recyclable catalyst for the conversion of CO2 with epoxides. Furthermore, it can also act as a sensitive and recyclable luminescent probe to detect CrO42−/Cr2O72− among many anions in aqueous solution.
From serendipity to supramolecular design: assessing the utility of computed crystal form landscapes in inferring the risks of crystal hydration in carboxylic acids
Authors: Mohamed Sharmarke , Li Liang
Published: June 2018

Calculated structural descriptors for predicted anhydrate polymorphs are used to assess the risks of crystal hydration in carboxylic acids.
Fluorogenic naked-eye sensing and live-cell imaging of cyanide by a hydrazine-functionalized CAU-10 metal–organic framework
Authors: Dalapati Rana , Nandi Soutick , Reinsch Helge , Bhunia Bibhas K. , Mandal Biman B. , Stock Norbert , Biswas Shyam
Published: June 2018

A hydrazine-functionalized Al(iii) based metal–organic framework was utilized for the detection of lethal cyanide in water and in living cells.
Studies on dynamics and isomerism in supercooled photochromic compound Aberchrome 670 with the use of different experimental techniques
Authors: Śmiszek-Lindert Wioleta Edyta , Kamińska Ewa , Minecka Aldona , Heczko Dawid , Madejczyk Olga , Tarnacka Magdalena , Jurkiewicz Karolina , Dzienia Andrzej , Kamiński Kamil , Paluch Marian
Published: June 2018

Broadband Dielectric Spectroscopy (BDS) was applied to monitor Z–E isomerization in a fulgide-type photochromic compound, Aberchrome 670 (Ab670).
Effect of an external electric field on capillary filling of water in hydrophilic silica nanochannels
Authors: Karna Nabin Kumar , Rojano Crisson Andres , Wagemann Enrique , Walther Jens H. , Zambrano Harvey A.
Published: June 2018

Development of functional nanofluidic devices requires understanding the fundamentals of capillary driven flow in nanochannels.
Selective CO2reduction to C3and C4oxyhydrocarbons on nickel phosphides at overpotentials as low as 10 mV
Authors: Calvinho Karin U. D. , Laursen Anders B. , Yap Kyra M. K. , Goetjen Timothy A. , Hwang Shinjae , Murali Nagarajan , Mejia-Sosa Bryan , Lubarski Alexander , Teeluck Krishani M. , Hall Eugene S. , Garfunkel Eric , Greenblatt Martha , Dismukes G. Charles
Published: June 2018

Bioinspired nickel phosphide electrocatalysts achieve breakthrough efficiency and selectivity for C3and C4products.
Pyrimidine-containing β-iminoenolate difluoroboron complexes acting as non-traditional π-gelators and mechanofluorochromic dyes
Authors: Mi Wenhua , Qu Zhiyu , Sun Jingbo , Zhang Fushuang , Zhai Lu , Zhao Jinyu , Ye Kaiqi
Published: June 2018

A xerogel-based film based on a mechanofluorochromic dye of a β-iminoenolate difluoroboron complex could detect TFA vapor with high performance.
A novel 6-quinoxalinamine-based fluorescent probe for real-time detection of palladium(ii) ions in pure water and bio-imaging
Authors: Che Chuanliang , Chen Xiangzhu , Wang Hongmei , Li Jia-Qi , Xiao Yumei , Fu Bin , Qin Zhaohai
Published: June 2018

A novel fluorescent probe LK based on a quinoxalinamine derivative exhibited excellent selectivity toward Pd2+ and could be used for bio-imaging.
Highly branched amine-functionalized p-sulfonatocalix[4]arene decorated with human plasma proteins as a smart, targeted, and stealthy nano-vehicle for the combination chemotherapy of MCF7 cells
Authors: Rahimi Mahdi , Karimian Ramin , Mostafidi Elmira , Bahojb Noruzi Ehsan , Taghizadeh Sepehr , Shokouhi Behrooz , Kafil Hossein Samadi
Published: June 2018

Nanotechnology has recently emerged as a promising field for biomedical applications, especially the targeted delivery of drugs to tumors.
Detection of gaseous amines with a fluorescent film based on a perylene bisimide-functionalized copolymer
Authors: Zhang Jinling , Liu Ke , Wang Gang , Shang Congdi , Peng Haonan , Liu Taihong , Fang Yu
Published: June 2018

A fluorescent copolymer containing PBI units and hydroxyl-ethyl structures was developed for the fast and sensitive detection of gaseous amines
Rational construction of core–shell Ni3S2@Ni(OH)2 nanostructures as battery-like electrodes for supercapacitors
Authors: Lin Jinghuang , Zheng Xiaohang , Wang Yiheng , Liang Haoyan , Jia Henan , Chen Shulin , Qi Junlei , Cao Jian , Fei Weidong , Feng Jicai
Published: June 2018

Core–shell Ni3S2@Ni(OH)2 nanostructures on Ni foam were fabricated via hydrothermal and chemical bath processes and showed good electrochemical performances.
Palladium-catalyzed reductive electrocarboxylation of allyl esters with carbon dioxide
Authors: Jiao Ke-Jin , Li Zhao-Ming , Xu Xue-Tao , Zhang Li-Pu , Li Yi-Qian , Zhang Kun , Mei Tian-Sheng
Published: June 2018

Palladium-catalyzed regioselective electrocarboxylation of homostyrenyl acetates with CO2 has been successfully developed, providing α-aryl carboxylic acids with good selectivity and yield.
A sequence-activated AND logic dual-channel fluorescent probe for tracking programmable drug release
Authors: Yan Chenxu , Guo Zhiqian , Liu Yajing , Shi Ping , Tian He , Zhu Wei-Hong
Published: June 2018

A sense-of-logic dual-channel nanoprobe is operated via a sequence-activated AND logic gate by responding ultra-sensitively to pH changes and being subsequently triggered with biothiol for the controllable release of anti-cancer drugs.
“Found in Translation”: predicting outcomes of complex organic chemistry reactions using neural sequence-to-sequence models
Authors: Schwaller Philippe , Gaudin Théophile , Lányi Dávid , Bekas Costas , Laino Teodoro
Published: June 2018

Using a text-based representation of molecules, chemical reactions are predicted with a neural machine translation model borrowed from language processing.
Osmotic pressure in polyelectrolyte solutions: cell-model and bulk simulations
Authors: Ullner Magnus , Qamhieh Khawla , Cabane Bernard
Published: June 2018

The osmotic pressure of polyelectrolyte solutions as a function of concentration has been calculated by simulations of a spherical cell model and by simulations with periodic boundary conditions.
Synergistic effects of a TiNb2O7–reduced graphene oxide nanocomposite electrocatalyst for high-performance all-vanadium redox flow batteries
Authors: Bayeh Anteneh Wodaje , Kabtamu Daniel Manaye , Chang Yu-Chung , Chen Guan-Cheng , Chen Hsueh-Yu , Lin Guan-Yi , Liu Ting-Ruei , Wondimu Tadele Hunde , Wang Kai-Chin , Wang Chen-Hao
Published: June 2018

In this study, a simple, low-cost, and powerful titanium niobium oxidereduced graphene oxide (TiNb2O7–rGO) nanocomposite electrocatalyst was synthesized through dispersion and blending in aqueous solution followed by freeze-drying and annealing for all-vanadium redox flow batteries (VRFBs).
Tannic acid encountering ovalbumin: a green and mild strategy for superhydrophilic and underwater superoleophobic modification of various hydrophobic membranes for oil/water separation
Authors: Wang Zhenxing , Ji Shengqiang , Zhang Jin , Liu Qixian , He Fang , Peng Shaoqin , Li Yuexiang
Published: June 2018

A mild and completely green strategy has been developed to transform various membranes into superhydrophilic membranes for oil/water separation.
A novel surface-heterostructured Li1.2Mn0.54Ni0.13Co0.13O2@Ce0.8Sn0.2O2−σ cathode material for Li-ion batteries with improved initial irreversible capacity loss
Authors: Liu Yanying , Yang Zhe , Li Jianling , Niu Bangbang , Yang Kai , Kang Feiyu
Published: June 2018

The modification of lithium-rich layered cathode materials has been widely studied by surface coating, doping and chemical treatment for lithium-ion batteries.
Hierarchical waxberry-like LiNi0.5Mn1.5O4 as an advanced cathode material for lithium-ion batteries with a superior rate capability and long-term cyclability
Authors: Sun Weiwei , Li Yujie , Liu Yumin , Guo Qingpeng , Luo Shiqiang , Yang Jinge , Zheng Chunman , Xie Kai
Published: June 2018

In this work, we have successfully synthesized hierarchically porous waxberry-like LiNi0.5Mn1.5O4 spheres comprising interpenetrating nanograins, and this material demonstrates an excellent rate capability and long-term cyclic stability.
Enhancing hydrophilicity of photoacoustic probes for effective ratiometric imaging of hydrogen peroxide
Authors: Lu Xiaomei , Zhao Meng , Chen Pengfei , Fan Quli , Wang Wenjun , Huang Wei
Published: June 2018

Hydrogen peroxide (H2O2) plays a significant role in regulating the redox balance in the living body.
Highly stable doping of a polar polythiophene through co-processing with sulfonic acids and bistriflimide
Authors: Hofmann Anna I. , Kroon Renee , Yu Liyang , Müller Christian
Published: June 2018

Upon doping with sulfonic acids and bistriflimide the polar polythiophene p(g42T-T) exhibits a maximum conductivity of 120 S cm−1 and can be hot-pressed into self-standing, flexible films.
Direct tuning of the band gap via electronically-active organic cations and large piezoelectric response in one-dimensional hybrid halides from first-principles
Authors: Tang Gang , Hong Jiawang
Published: June 2018

By inserting C7H7+ cations into 1D GAPbI3, the band gap is directly narrowed from 2.28 to 0.69 eV. In addition, a large piezoelectric response is also predicted in 1D GAPbI3.
New tools for evaluating protein tyrosine sulfation: tyrosylprotein sulfotransferases (TPSTs) are novel targets for RAF protein kinase inhibitors
Authors: Byrne Dominic P. , Li Yong , Ngamlert Pawin , Ramakrishnan Krithika , Eyers Claire E. , Wells Carrow , Drewry David H. , Zuercher William J. , Berry Neil G. , Fernig David G. , Eyers Patrick A.
Published: June 2018

Protein tyrosine sulfation is a post-translational modification best known for regulating extracellular protein–protein interactions. Tyrosine sulfation is catalysed by two Golgi-resident enzymes termed tyrosylprotein sulfotransferases (TPSTs) 1 and 2, which transfer sulfate from the cofactor PAPS (3′-phosphoadenosine 5′-phosphosulfate) to a context-dependent tyrosine in a protein substrate. A lack of quantitative tyrosine sulfation assays has hampered the development of chemical biology approaches for the identification of small-molecule inhibitors of tyrosine sulfation. In the present paper, we describe the development of a non-radioactive mobility-based enzymatic assay for TPST1 and TPST2, through which the tyrosine sulfation of synthetic fluorescent peptides can be rapidly quantified. We exploit ligand binding and inhibitor screens to uncover a susceptibility of TPST1 and TPST2 to different classes of small molecules, including the anti-angiogenic compound suramin and the kinase inhibitor rottlerin. By screening the Published Kinase Inhibitor Set, we identified oxindole-based inhibitors of the Ser/Thr kinase RAF (rapidly accelerated fibrosarcoma) as low-micromolar inhibitors of TPST1 and TPST2. Interestingly, unrelated RAF inhibitors, exemplified by the dual BRAF/VEGFR2 inhibitor RAF265, were also TPST inhibitors in vitro. We propose that target-validated protein kinase inhibitors could be repurposed, or redesigned, as more-specific TPST inhibitors to help evaluate the sulfotyrosyl proteome. Finally, we speculate that mechanistic inhibition of cellular tyrosine sulfation might be relevant to some of the phenotypes observed in cells exposed to anionic TPST ligands and RAF protein kinase inhibitors.
WITHDRAWN: Fibroblasts from pBOO promote tumorigenesis by secreting TGFbeta1 to induce EMT in bladder urothelial carcinoma cells
Authors: Lu Xiongbing , Duan Lingxing , Zhang Jian , Zeng Zhihua , Kuang Renrui
Published: June 2018

The Accepted Manuscript version of this article (published on 22 June 2018) was withdrawn on 9 April 2021 at the request of the authors. Despite numerous attempts to contact the authors, the Editorial Office have been unable to receive a reason behind the withdrawal request.
Role of RNF20 in cancer development and progression – a comprehensive review
Authors: Sethi Gautam , Shanmugam Muthu K. , Arfuso Frank , Kumar Alan Prem
Published: June 2018

Evolving strategies to counter cancer initiation and progression rely on the identification of novel therapeutic targets that exploit the aberrant genetic changes driving oncogenesis. Several chromatin associated enzymes have been shown to influence post-translational modification (PTM) in DNA, histones, and non-histone proteins. Any deregulation of this core group of enzymes often leads to cancer development. Ubiquitylation of histone H2B in mammalian cells was identified over three decades ago. An exciting really interesting new gene (RING) family of E3 ubiquitin ligases, known as RNF20 and RNF40, monoubiquitinates histone H2A at K119 or H2B at K120, is known to function in transcriptional elongation, DNA double-strand break (DSB) repair processes, maintenance of chromatin differentiation, and exerting tumor suppressor activity. RNF20 is somatically altered in breast, lung, prostate cancer, clear cell renal cell carcinoma (ccRCC), and mixed lineage leukemia, and its reduced expression is a key factor in initiating genome instability; and it also functions as one of the significant driving factors of oncogenesis. Loss of RNF20/40 and H2B monoubiquitination (H2Bub1) is found in several cancers and is linked to an aggressive phenotype, and is also an indicator of poor prognosis. In this review, we summarized the current knowledge of RNF20 in chronic inflammation-driven cancers, DNA DSBs, and apoptosis, and its impact on chromatin structure beyond the single nucleosome level.
Perinatal administration of phencyclidine alters expression of Lingo-1 signaling pathway proteins in the prefrontal cortex of juvenile and adult rats
Authors: Andrews Jessica L. , Newell Kelly A. , Matosin Natalie , Huang Xu-Feng , Fernandez Francesca
Published: June 2018

Postnatal administration of phencyclidine (PCP) in rodents causes major brain dysfunction leading to severe disturbances in behavior lasting into adulthood. This model is routinely employed to model psychiatric disorders such as schizophrenia, as it reflects schizophrenia-related brain disturbances including increased apoptosis, and disruptions to myelin and plasticity processes. Leucine-rich repeat and Immunoglobin-like domain-containing protein 1 (Lingo-1) is a potent negative regulator of both axonal myelination and neurite extension. The Nogo receptor (NgR)/tumor necrosis factor (TNF) receptor orphan Y (TROY) and/or p75 neurotrophin receptor (p75) complex, with no lysine (K) (WNK1) and myelin transcription factor 1 (Myt1) are co-receptors or cofactors in Lingo-1 signaling pathways in the brain. We have examined the developmental trajectory of these proteins in a neurodevelopmental model of schizophrenia using PCP to determine if Lingo-1 pathways are altered in the prefrontal cortex throughout different stages of life. Sprague–Dawley rats were injected with PCP (10 mg/kg) or saline on postnatal days (PN)7, 9, and 11 and killed at PN12, 5 or 14 weeks for measurement of Lingo-1 signaling proteins in the prefrontal cortex. Myt1 was decreased by PCP at PN12 (P=0.045), and at 14 weeks PCP increased Lingo-1 (P=0.037), TROY (P=0.017), and WNK1 (P=0.003) expression. This is the first study reporting an alteration in Lingo-1 signaling proteins in the rat prefrontal cortex both directly after PCP treatment in early development and in adulthood. We propose that Lingo-1 pathways may be negatively regulating myelination and neurite outgrowth following the administration of PCP, and that this may have implications for the cortical dysfunction observed in schizophrenia.
Stuttering and Labor Market Outcomes in the United States
Authors: Gerlach Hope , Totty Evan , Subramanian Anu , Zebrowski Patricia
Published: June 2018

Purpose

The purpose of this study was to quantify relationships between stuttering and labor market outcomes, determine if outcomes differ by gender, and explain the earnings difference between people who stutter and people who do not stutter.

Method

Survey and interview data were obtained from the National Longitudinal Study of Adolescent to Adult Health. Of the 13,564 respondents who completed 4 waves of surveys over 14 years and answered questions about stuttering, 261 people indicated that they stutter. Regression analysis, propensity score matching, and Blinder–Oaxaca decomposition were used.

Results

After controlling for numerous variables related to demographics and comorbidity, the deficit in earnings associated with stuttering exceeded $7,000. Differences in observable characteristics between people who stutter and people who do not stutter (e.g., education, occupation, self-perception, hours worked) accounted for most of the earnings gap for males but relatively little for females. Females who stutter were also 23% more likely to be underemployed than females who do not stutter.

Conclusions

Stuttering was associated with reduced earnings and other gender-specific disadvantages in the labor market. Preliminary evidence indicates that discrimination may have contributed to the earnings gap associated with stuttering, particularly for females.
Effect of collagen‐induced residual stress on the frictional property of articular cartilage
Authors: Fujie Hiromichi , Morishita Sou , Yarimitsu Seido
Published: June 2018

Previous findings, such as split‐line of the articular cartilage surface and curving of sliced cartilage specimen, would suggest that residual stress is contained in articular cartilage. This study was performed to determine the effect of collagen fibre‐induced residual stress on the biphasic lubrication property of articular cartilage. A fibre‐reinforced poroelastic model of articular cartilage was developed in Abaqus. In the model, residual stress was contained in the collagen fibre in the surface layer by applying 1–5% of tensile strain. Reciprocating friction analysis was performed between the model and a sphere at a friction speed of 1.0–10.0 mm/s. Results revealed that the coefficients of start‐up and dynamic friction at second friction cycle were lower in residual stress model than in no‐residual stress model, with the largest decreases observed at a friction speed of 1 mm/s. It was observed that rehydration was promoted in the bearing area in residual stress model. These results suggest that collagen‐induced residual stress plays an important role in enhancing the biphasic lubrication property of articular cartilage.
Hybrid graphene aerogel intermedium for bendable supercapacitor electrode
Authors: Mi Jinbo , Wang Yongliang , Han Zhidong
Published: June 2018

Porous structure materials indicate brilliant distribution and great absorption ability, that suggesting the potential application of aerogel state graphene based materials. Aerogel intermedium assisted method was developed and optimised to prepare bendable electrode. Hydrothermal schedule was utilised suggesting potential application at low cost and large‐scale factory print issues, rather than consuming high money cost and long labour time. Nickel sulphide has been anchored onto the graphene aerogels via one‐pot hydrothermal method. The membrane electrode was made with the carbon ink and aerogel intermedium on the Poly(ethylene terephthalate) (PET) plate. The bendable electrode was fabricated with intermedium and commercial carbon ink, and indicates good performance and economic consumption. The complex membrane capacitor shows the much more brilliant performance than the pure carbon membrane capacitor, with specific capacitance (31.40 mF/cm2 at 4 mV/s and 17.74 mF/cm2 at 2 mA/cm2).
Progrés et défis pour la cryptographie quantique
Authors: Diamanti Eleni
Published: June 2018

La cryptographie quantique, et plus particulièrement la distribution quantique de clés, promet la communication des données avec une sécurité absolue, indépendante des capacités d’un espion éventuel. Malgré des progrès significatifs, pour son utilisation dans une large gamme d’applications, des défis liés à la performance, le coût et la sécurité pratique des systèmes devront être abordés les prochaines années.
A vendor managed inventory on consignment with penalty as a supply chain coordination arrangement
Authors: Taleizadeh Ata Allah , Tavakoli Shayan , Konstantaras Ioannis , Rabbani Masoud
Published: June 2018

This paper presents a mathematical two echelon vendor-managed inventory (VMI) model on consignment scheme in supply chain, in which the vendor pays a penalty for every extra unit which exceeds a specific upper limit to the buyer. In this arrangement the vendor can decide about the batch size he wants to transship to the buyer. Two cases are discussed in this paper; single vendor-single buyer and single vendor-two buyers. In this study after a review of coordination in supply chain and VMI on consignment, we discuss vendor-managed inventory scheme in comparison with traditional inventory control system. The optimal batch size is calculated and the paper investigates how a VMI on consignment arrangement with penalty can coordinate the supply chain. Numerical examples and sensitivity analysis is presented to illustrate the performance of model and the results.
Der Schlüssel zur Begeisterungskultur
Authors: Schröder Jörg-Peter
Published: June 2018

Mitarbeiter in OP-Teams magisch anzuziehen ist Chefsache. Workshops zur Umsetzung von transformationaler Führung können bei der Mitarbeiterbindung einen
wichtigen Beitrag leisten, denn der Führungsstil der Vorgesetzten beeinflusst die Mitarbeitermotivation massiv. Lesen Sie, wie Sie mit Klarheit,
Entscheidungsfreude, Begeisterungsfähigkeit und Wertschätzung eine Begeisterungskultur im OP kreieren können.
Harte oder weiche Hülle?
Authors: Hönle Birgitt
Published: June 2018

Welches System zur Sterilgutver- und -entsorgung bevorzugen Sie: Container oder Weichverpackungen? Unsere Autorin erklärt die Vor- und Nachteile der
unterschiedlichen Systeme und gibt praktische Tipps für den Arbeitsalltag.
Opfer von Gewalttaten im Verfahren nach dem Opferentschädigungsgesetz
Authors: Franke Stefanie , Kalweit Christine , Frey Annelene , Heddergott Hanna , Mitschke Astrid-Christine , Wehrmeyer Matthias , Heinrichs Nina , Kröger Christoph
Published: June 2018

Ziel der Studie Bei Opfern von Gewalttaten spielt die Bewältigung des psychischen Traumas oft eine zentrale Rolle. Das Opferentschädigungsgesetz (OEG) sieht Leistungen zur Wiederherstellung der Teilhabefähigkeit vor. Um die Versorgung Betroffener weiter zu verbessern, wurden Charakteristika der Opfer in Abhängigkeit von Taten und Tätern ermittelt.

Methodik Anhand eines Kategoriensystems wurden aus 312 OEG-Akten Erwachsener demografische Angaben, traumaspezifische und gesundheitliche Merkmale der Opfer, relevante Merkmale der Täter, der Gewalt sowie Prädiktoren der Zeitdifferenz zwischen Tat und Antragstellung erfasst.

Ergebnisse Zumeist waren Frauen betroffen (71%). Bei 49% der Betroffenen lagen körperliche, bei 87% psychische Schädigungsfolgen vor (davon bei 64% eine posttraumatische Belastungsstörung). 55% der Gewalttaten waren Sexualdelikte, 47% Körperverletzung, bei 44% lag zusätzlich psychische Misshandlung vor. Die Täter kamen häufig aus dem Umfeld des Opfers. 42% der Delikte betrafen häusliche Gewalt. Die Zeitdauer zwischen der Schädigung und OEG-Antragstellung variierte zwischen 0 und 52 Jahren (M=7,81, SD=12,48). 50% der Anträge wurden innerhalb eines Jahres und weitere 15,2% innerhalb von 5 Jahren gestellt. Bei 34,3% betrug die Zeitdauer über 5 Jahre. Bei seriellen bzw. schweren Traumatisierungen, Depression und enger Beziehung zwischen Opfer und Täter wurde die gesetzlich vorgesehene Hilfe erst spät in Anspruch genommen.

Schlussfolgerung Viele Opfer von Gewalttaten sind psychisch traumatisiert. Um zu verhindern, dass sich Traumafolgen als dauerhafte Gesundheitsstörungen verfestigen, sollte das Angebot frühzeitiger professioneller evidenzbasierter Akuttherapie (z. B. in Trauma-Ambulanzen) weiter optimiert werden.
Current Status of the Radiologic Assessment of Diverticular Disease
Authors: Kandagatla Pridvi , Stefanou Amalia
Published: June 2018

Radiologic assessment plays a vital role in the management of diverticulitis. It not only helps in the diagnosis, but also helps to guide the management. As technology has progressed, different modalities have offered insight into the treatment of this disease process. Through various trials and studies, certain modalities stand above the rest in terms of sensitivity and specificity. Computed tomography (CT) imaging has also proved to help us guide the management through a grading system. Newer studies show us the advantages of other modalities such as ultrasound and magnetic resonance imaging (MRI). Though there is much research yet to be done with these modalities, they do show a lot of potential.