bluuebunny/crossref_metadata_2025 huggingface dataset:
Waist Circumference as a Predictor for Menstrual Cycle Disturbance Among College Student
Authors: Purwanto Bambang , Rtamagustini Ni Nyoman Trioka , Dharmayanti Hanifa Erlin
Published: June 2019

Introduction: Menstrual cycle disturbance is the sign of a reproductive health problem, yet the cause tends to be multifactorial. This study aimed to analyze the risk factors of menstrual cycle disturbance which related to nutrition status among college students.Methods: This was an observational analytical study with a cross-sectional approach. There were 59 participants taken as samples according to inclusion criteria using proportionate stratified random sampling. Data were analyzed with chi-square and multiple logistic regression test.Results: Results found that 35.6% of participants experienced menstrual cycle disturbance. Bivariate analysis showed significant correlation between body fat percentage (p= 0.038, OR: 2.417) and waist circumference (p= 0.003, OR: 2.956) with menstrual cycle disturbance, otherwise no correlation found between Body Mass Index (BMI) (p= 0.052, OR: 2.145), subcutaneous fat thickness (p= 1, OR: 1.279), and total cholesterol levels (p= 1, OR: 1.063) with menstrual cycle disturbance. Multiple logistic regression analysis showed that waist circumference became determinant factor among other variables predicting menstrual cycle disturbance in this study (p= 0.002, OR: 7.260).Conclusion: Waist circumference and body fat percentage were both risk factors of menstrual cycle disturbance, yet waist circumference was found being a determinant predictor to predict menstrual cycle disturbance among college student. Female students may pay particular attention to their waist circumference for detection of reproductive health problem earlier, especially regarding menstruation cycle disturbance.
KAMU HASTANELERİNDE İŞ SAĞLIĞI ve GÜVENLİĞİ UYGULAMALARININ ÇALIŞANLARIN İŞ PERFORMANSINA ETKİSİ: BURDUR İLİ ÖRNEĞİ - THE EFFECT OF OCCUPATIONAL HEALTH AND SAFETY PRACTICES ON WORK PERFORMANCE OF PUBLIC HOSPITALS: BURDUR PROVINCE CASE
Authors: KAVGACI Yüksel , ÇİÇEK Hüseyin
Published: June 2019

Araştırmanın amacı kamu hastanelerindeki iş sağlığı ve güvenliği uygulamalarının, çalışanların iş performansı üzerine etkilerini ortaya koymaktır. Araştırmanın evrenini Mayıs 2016 tarihi itibarı ile Burdur ilindeki 4 kamu hastanesinin kadrolu çalışanları oluşturmaktadır. Araştırmada kolayda örnekleme yöntemi kullanılmıştır. Örneklemi oluşturan 554 çalışana ulaşmak için 800 anket gönderilmiş, bunlardan 570 tanesi geri dönmüş ve 554 anket değerlendirmeye alınmıştır.  Verilerin toplanmasında hastanede çalışan sağlık personeli için iş güvenliği ölçeği, iş sağlığı ve güvenliği ölçeği ve iş performansı ölçeği kullanılmıştır. Bağımlı değişken olan iş performansı ile bağımsız değişken olan İSG uygulamalarının alt faktörleri arasındaki ilişkileri belirlemek için Pearson Korelasyon analizi ve etkileri ortaya koymak için Çoklu Regresyon analizinden faydalanılmıştır.Araştırmanın sonucunda İSG uygulamaları alt boyutlarının tamamının iş performansı ile pozitif yönlü doğrusal ilişkisi olduğu, çoklu regresyon analizi sonucuna göre sağlık taraması ve kayıt sistemleri, malzeme, araç ve gereç denetimi ile koruyucu önlemler ve kurallar alt boyutlarının iş performansını pozitif yönlü ve anlamlı şekilde etkilediği, diğer alt boyutlarının anlamlı olmadığı sonucuna ulaşılmıştır. Çalışanların hasta veya hasta yakını tarafından sözel veya fiziksel şiddete maruz kalma oranı %90,2, hastane çalışanları tarafından sözel veya fiziksel şiddete maruz kalma oranı %57,2 çıkmıştır. Bu yüksek oran kamu hastanelerinde yaşanan şiddet ve mobingi ortaya koymaktadır.
ULUSLARARASI SERMAYE AKIMLARININ MAKROEKONOMİK GÖSTERGELER İLE İLİŞKİSİ - THE RELATIONSHIP OF INTERNATIONAL CAPITAL FLOWS WITH MACROECONOMIC INDICATORS
Authors: KOVUSOVA Şirin , BULUT Remzi
Published: June 2019

Günümüz ekonomilerinde uluslararası sermaye hareketlerinin ülke ekonomisinin üzerindeki etkileri araştırılmaktadır. Özellikle sermaye hareketlerinin serbestleşmesiyle doğrudan yabancı yatırımlar gelişmiş ülkelerden gelişmekte olan ülkelere kaymaktadır. Dışa açık ekonomi politikaları izlemeye başlayan gelişmekte olan ülkeler uluslararası sermaye hareketlerini kendi ülkelerine çekmek için yabancı yatırımcıları teşvik edici politikalar izlemişlerdir. Gelişmekte olan ülkelere giren yabancı yatırımlar o ülkenin ekonomisi üzerinde hem olumlu hem de olumsuz etkiler oluşturmuştur. Bağımsızlığını kazandıktan sonra diğer gelişmekte olan ülkeler gibi Türkmenistan, Azerbaycan, Kırgızistan, Özbekistan ve Kazakistan Cumhuriyetlerinde, ülke ekonomisinin istikrarlı büyümesi için dışa açık, ihracatı arttırıcı politikalar izlenmeye başlamıştır. Yabancı yatırımları ülkeye çekmek amaçlı ekonomik politikalar uygulanmıştır. Bu çalışmada söz konusu ülkelerin bağımsızlığını kazandıktan sonraki dönemlerde uygulanan politikalar sonucunda ülkeye giren uluslararası sermaye hareketlerinin ülke ekonomisi üzerindeki etkileri ve sonuçları ekonometrik olarak ortaya konulmaya çalışılmıştır. 1996-2016 yılları arasındaki veriler kullanılarak panel veri ekonometrisi analizleri yapılmıştır. Çalışmada elde edilen sonuca göre doğrudan yabancı yatırımların ihracat ile doğru orantılı, enflasyonla ters orantılı bir ilişkisi vardır. Çalışmanın en belirgin sonucu beklenenin aksine incelediğimiz dönemde GSYH’nın tahmin katsayısının negatif ve istatistiki olarak anlamsız çıkmasıdır.
Integrated Assessment of the Quality of Sediments of Open Pit Lakes and the Impact on the Environment
Authors: Fagundes Barbara Viniciu , de Melo e Silva Daniela , Gonçalves Barros Rosana , Muro Jr Aldo , Antoniosi Filho Nelson Roberto
Published: June 2019

The mining industry is known for the intense environmental impacts it triggers, especially when it is developed in an open environment. Pit lakes are formed in depleted deposits and may be promising opportunities for use by society as well as troubling environmental liabilities. While these artificial basins are increasing numerically in many parts of the world, they are still little known researchers in the Environmental Sciences, which makes their environmental management challenging. The main objective of this study was to evaluate the environmental quality of sediments from three deactivated open-pit gold mines, located in the Mara Rosa, Brazil, through chemical, ecotoxicological and genotoxicology analyses. For this purpose, we collected samples in the dry season boom, and subsequently, we analysed metals. In sequence, acute ecotoxicological and a genotoxicology test (comet assay) were developed with Danio rerio fishes, in concentrations of 3.12%; 6.25%; 12.5%; 25%; 50% and 100%, in addition to the control group. The results indicated that the three lakes are environmentally compromised, especially Lago Azul, whose waters and sediments are undergoing an intense process of geological conditioning. Our results did not verify the ecotoxicity of the sediments of any of the lakes, only behavioural alterations in the test organisms exposed to the concentrations of 25%, 50% and 100% of the samples obtained in the Lago Azul. About the sediments, DNA damage at Danio rerio was detected in the three investigated environments, although fishes kept in the water sampled at Lago Azul presented the most extension of DNA damages.
Temporally and Spatially Resolved Emission Spectroscopy of Cyanide, Hydrogen and Carbon in Laser-Induced Plasma
Authors: Parigger Christian G. , Helstern Christopher M. , Gautam Ghaneshwar
Published: June 2019

This work examines atomic and molecular signatures in laser-induced plasma in standard ambient temperature and pressure environments, including background contributions to the spectra that depend on the laser pulse-width. Investigations include solids, gases, and nano-particles. Abel inversions of measured line-of-sight data reveal insight into the radial plasma distribution. For nominal 6 nanosecond laser pulses and for pulse-energies in the range of 100 to 800 mJ, expansion dynamics and turbulence due to shock phenomena are elucidated to address local equilibrium details that are frequently assumed in spatially averaged emission spectroscopy. Chemical equilibrium computations reveal temperature dependence of selected plasma species. Specific interests include atomic hydrogen (H) and cyanide (CN). Atomic hydrogen spectra indicate axisymmetric shell structures and isentropic expansion of the plasma kernel over and above the usual shockwave. The recombination radiation of CN emanates within the first 100 nanoseconds for laser-induced breakdown in a 1:1 CO2:N2 gas mixture when using nanosecond laser pulses to create the micro-plasma. The micro-plasma is generated using 1064 nm, 150 mJ, 6 ns Q-switched Nd:YAG laser radiation. Measurements of the optical emission spectra utilize a 0.64 m Czerny-Turner type spectrometer and an intensified charge-coupled device.
OPTIMALISASI PERAN DEWAN PENGAWAS SYARIAH (DPS) DALAM PERBANKAN SYARIAH DI MEDAN
Authors: Rokan Mustapa Khamal
Published: June 2019

Structure of sharia supervision board implements Islamic Economics law into business transactions through sharia supervision processes. This article aims to define sharia supervision and examine sharia supervisory councils. It also discusses the importance of the hierarchical position DPS and evaluates their objectives and functions. It reviews a wide range of theoretical literatures, especially recent proceedings of relevant conferences in Indonesia along with the standards of National Sharia board or Dewan Syariah Nasional, Dewan Ulama Indonesia (DSN-MUI). A framework for understanding the role of the DPS developed suggests a set of objectives and functions for the DPS. The paper finds a lack of standardization among the DPS concerning the position of the DPS within the corporate hierarchy. DPS cannot be able to give innovation product to solve sharia banks problems. Therefore, sharia supervision board needs to be valued seriously and well.
Harnessing Progress in Psychiatric Genetics to Advance Population Mental Health
Authors: Merikangas Kathleen Ries , Merikangas Alison K.
Published: June 2019

Advances in genomics and neuroscience have ushered in unprecedented opportunities to increase our understanding of the biological underpinnings of mental disorders, yet there has been limited progress in translating knowledge on genetic risk factors to reduce the burden of these conditions in the population.

We describe the challenges and opportunities afforded by the growth of large-scale population health databases, progress in genomics, and collaborative efforts in epidemiology and neuroscience to develop informed population-wide interventions for mental disorders. Future progress is likely to benefit from the following efforts: expansion of large collaborative studies of mental disorders to include more systematically ascertained multiethnic samples from biobanks and registries, harmonization of phenotypic characterization in registry and population samples to extend clinical diagnosis to transdiagnostic concepts, systematic investigation of the influences of both specific and nonspecific environmental factors that may combine with genetic susceptibility to confer increased risk of specific mental disorders, and implementation of study designs that can inform gene–environment interactions.

Such data can ultimately be combined to develop comprehensive models of risks of, interventions for, and outcomes of mental disorders. With its focus on phenotypic characterization, sampling, study designs, and analytic methods, epidemiology will be central to progress in translating genomics to public health.
Disparities in Access to Health Care Among US-Born and Foreign-Born US Adults by Mental Health Status, 2013–2016
Authors: Dedania Reema , Gonzales Gilbert
Published: June 2019

Objectives. To compare access to care between US-born and foreign-born US adults by mental health status.

Methods. We analyzed data on nonelderly adults (n = 100 428) from the 2013–2016 National Health Interview Survey. We used prevalence estimates and multivariable logistic regression models to compare issues of affordability and accessibility between US-born and foreign-born individuals.

Results. Approximately 22.2% of US-born adults and 18.1% of foreign-born adults had symptoms of moderate to severe psychological distress. Compared with US-born adults with no psychological distress, and after adjustment for sociodemographic characteristics, US-born and foreign-born adults with psychological distress were much more likely to report multiple emergency room visits and unmet medical care, mental health care, and prescription medications because of cost.

Conclusions. Our study found that adults with moderate to severe psychological distress, regardless of their immigration status, were at greater risk for reporting issues of affordability when accessing health care compared with US-born adults with no psychological distress.

Public Health Implications. Health care and mental health reforms should focus on reducing health care costs and establishing innovative efforts to broaden access to care to diverse populations.
Modeling the Interaction Between Natural and Hydraulic Fractures Using 3D Finite-Element Analysis
Authors: Nikam Aditya , Awoleke Obadare O. , Ahmadi Mohabbat
Published: June 2019

We built a 3D geomechanical model using commercially available finite–element–analysis (FEA) software to simulate a propagating hydraulic fracture (HF) and its interaction with a vertical natural fracture (NF) in a tight medium. These newly introduced elements have the ability to model the fluid continuity at an HF/NF intersection, the main area of concern.

We observed that, for a high–stress–contrast scenario, the NF cohesive elements showed less damage when compared with the low–stress–contrast case. Also, for the scenario of high stress contrast with principal horizontal stresses reversed, the HF intersected, activated, and opened the NF. Increasing the injection rate resulted in a longer and wider HF but did not significantly affect the NF–activated length. Injection–fluid viscosity displayed an inverse relationship with the HF length and a proportional relationship with the HF opening or width. We observed that a weak NF plane temporarily restricts the HF propagation. On the other hand, a tougher NF, or an NF with properties similar to its surroundings, does not show this type of restriction. The NF activated length was found at its maximum in the case of a weaker NF and at nearly zero in the case of a stronger NF and an NF that has strength similar to its surroundings.

In this study we present the results for a three–layered 3D geomechanical model with a single HF and NF orthogonally intersecting each other, using newly introduced cohesive elements for the first time in technical literature. We also conducted a detailed sensitivity analysis considering the effect of stress contrast, injection rate, injection–fluid viscosity, and NF properties on this HF/NF interaction. These results provide an idea of how the idealized resultant fracture geometry will change when several fracture/fracture treatment properties are varied.
The prevalence and risk factors of Early Childhood Caries among 3-year-old children in Wenzhou
Authors: Mei Liqin , Wei Zhiyuan , Li Qiao , Wang Xiping
Published: June 2019

Background: This study aimed to investigate the prevalence and risk factors of Early Childhood Caries (ECC) among 3-year-old children in Wenzhou China.
Methods: Preschool children aged 3 were recruited using a stratified cluster sampling method. Dental examinations were carried out by one trained dentist, and oral health-related data were collected. Examinations were surface-specific for dental caries, following World Health Organization (WHO) criteria. Bivariate tests and logistic regression models were used to investigate the risk factors of dental caries.
Results: A total of 693 children were recruited for the study, and 445 completed the dental examination. Among the 445 children, the prevalence of ECC was 59.8%. The mean decayed, missing, and filled primary teeth (dmft) was 2.9, and of the total dmft, only 6.3% were filled. The mean decayed, missing, and filled primary surface (dmfs) was 4.9. Logistic regression analyses identified age and parents’ oral health knowledge level were associated with the experience of ECC (P<0.05).
Conclusions: A higher prevalence of ECC was observed and most of the carious teeth were not restored. The experience of ECC was related to age and parents’ oral health knowledge level.
Comparison between Ologen implant and Mitomycin C in trabeculectomy: A Systematic Review and Meta-Analysis
Authors: Liu Xiaoyan , Du Yali , Lei Min , Zhuang Leyi , Lv Peng
Published: June 2019

Objective

To evaluate the effectiveness and safety of the biodegradable collagen matrix (Ologen) implant in trabeculectomy.

Research design and methods

We searched Pubmed, Cochrane library, Embase and Web of Science databases to find studies that met our pre-stated inclusion criteria. Reference lists of retrieved articles were also reviewed. The search was finished by February 2019. Study selection, data extraction, quality assessment, and data analyses were performed according to the Cochrane standards. Either a fixed or a random-effects model was used to calculate the overall combined risk estimates. The efficacy measures were the weighted mean differences (WMDs) for the intraocular pressure reduction (IOPR) and the glaucoma medications reduction, the odds ratio (OR) for the success rate and adverse events.

Results

Fifteen randomized controlled trials involved 682 eyes were included in the meta-analysis. There were no statistically differences between two groups in the IOPR at any time postoperatively. The MD of the IOPR was [MD= -0.45,95% Confidence Interval (CI), (-2.36,1.46), P=0.65] at one day, [MD= -0.82,95% CI, (-1.97, 0.33), P=0.16] at one week, [MD= -1.33, 95% CI,(-3.12, 0.47), P=0.15] at one month, [MD= 0.11,95% CI, (-1.87, 2.08), P=0.92] at three months, [MD= -0.60,95% CI, (-2.27, 1.06), P=0.48] at six months, [MD= -0.33,95% CI, (-1.99, 1.32), P=0.69] at one year, [MD= -0.13,95% CI, (-1.90, 1.65), P=0.89] at two years, [MD= 2.54,95% CI, (-2.83, 7.90), P=0.35] at three years, [MD= 3.04,95% CI, (-3.95, 10.03), P=0.39] at five years. There was no statistically significant difference between the Ologen groups and MMC groups concerned the complete success rate [OR=1.19, 95%CI, (0.83, 1.71), P=0.35]. With regard to the adverse events, no obvirously significance was observed. Seven studies reported the change of antiglaucoma medications. We found that the change of antiglaucoma medications is higher in MMC groups than that in Ologen groups [MD=-0.18, 95%CI, (-0.33, -0.03), P=0.02]. There is no significant difference in complications between the two groups.

Conclusions

From the current evidence, Ologen may be an alternative choice for trabeculectomy when considering the efficacy and safety. However, MMC might be the preferred choice concerned cost-effectiveness.
The Prevalence of Obstructive Sleep Apnea in Mild Cognitive Impairment: A Systematic Review
Authors: Mubashir Talha , Abrahamyan Lusine , Niazi Ayan , Piyasena Deween , Arif Abdul A. , Wong Jean , Osorio Ricardo S. , Ryan Clodagh M. , Chung Frances
Published: June 2019

Background: Previous studies have shown that obstructive sleep apnea (OSA) is associated with a higher risk of cognitive impairment or dementia in the elderly, leading to deleterious health effects and decreasing quality of life. This systematic review aims to determine the prevalence of OSA in patients with mild cognitive impairment (MCI) and examine whether an association between OSA and MCI exists. Methods: We searched Medline, PubMed, Embase, Cochrane Central, Cochrane Database of Systematic Reviews, PsychINFO, Scopus, the Web of Science, ClinicalTrials.gov and the International Clinical Trials Registry Platform for published and unpublished studies. We included studies in adults with a diagnosis of MCI that reported on the prevalence of OSA. Two independent reviewers performed the abstract and full-text screening, data extraction and the study quality critical appraisal. Results: Five studies were included in the systematic review. Overall, OSA prevalence rates in patients with MCI varied between 11−71% and were influenced by OSA diagnostic methods and patient recruitment locations (community or clinic based). Among studies using the following OSA diagnostic measures– self-report, ApneaLink, Berlin Questionnaire and polysomnography– the OSA prevalence rates in MCI were 11%, 27%, 59% and 70%, respectively. In a community-based sample, the prevalence of OSA in patients with and without MCI was 27% and 26%, respectively. Conclusions: Based on limited evidence, the prevalence of OSA in patients with MCI is 27% and varies based upon OSA diagnostic methods and patient recruitment locations. Our findings provide an important framework for future studies to prospectively investigate the association between OSA and MCI among larger community-based cohorts and implement a standardized approach to diagnose OSA in memory clinics. PROSPERO registration: CRD42018096577
Factors controlling the crystal morphology and chemistry of garnet in skarn deposits: A case study from the Cuihongshan polymetallic deposit, Lesser Xing'an Range, NE China
Authors: Fei Xianghui , Zhang Zhaochong , Cheng Zhiguo , Santosh M.
Published: June 2019

The grossular-andradite solid solutions in garnet from skarn deposits in relation to hydrothermal processes and physicochemical conditions of ore formation remain controversial. Here we investigate garnet occurring in association with calcic and magnesian skarn rocks in the Cuihongshan polymetallic skarn deposit of NE China. The calcic skarn rocks contain three types of garnets. (1) Prograde type I Al-rich anisotropic garnets display polysynthetic twinning and a compositional range of Grs18–80Adr10–75. This type of garnet shows markedly low rare earth element (REE) contents (3.27–78.26 ppm) and is strongly depleted in light rare earth elements (LREE, 0.57–44.65 ppm) relative to heavy rare earth elements (HREE, 2.31–59.19 ppm). They also display a significantly negative Eu anomaly (Eu/Eu* of 0.03–0.90). (2) Fe-rich retrograde type II garnets are anisotropic with oscillatory zoning and own wide compositional variations (Grs1–47Adr30–95) with flat REE (13.73–377.08 ppm) patterns. (3) Fe-rich retrograde type III isotropic garnets display oscillatory zoning and morphological transition from planar dodecahedral {110} crystal faces to {211} crystal faces in the margin. Types III garnets exhibit relatively narrow compositional variations of Grs0.1–12Adr85–97 with LREE-enrichment (0.80–51.87 ppm), flat HREE patterns (0.15–2.46 ppm) and strong positive Eu anomalies (Eu/Eu* of 0.93–27.07 with almost all >1). The magnesian skarn rocks contain euhedral isotropic type IV Mn-rich garnet veins with a composition of Grs10–23Sps48–62Alm14–29. All calcic garnets contain considerable Sn and W contents. Type II garnet containing intermediate compositions of andradite and grossular shows the highest Sn contents (64.36–2778.92 ppm), albeit the lowest W range (1.11–468.44 ppm). Birefringence of garnet is probably caused by strain from lattice mismatch at a twinning boundary or ion substitution near intermediate compositions of grossular-andradite. The fine-scale, sharp, and straight garnet zones are probably caused by self-organization, but the compositional variations of zones from core to rim are probably caused by external factors. The zoning is likely driven by external factors such as composition of the hydrothermal fluid. REE concentrations are probably influenced by the relative proportion and temperature of the system. Moreover, the LREE-HREE fractionation of garnet can be attributed to relative compositions of grossular-andradite system. The W and Sn concentrations in garnet can be used as indicators for the exploration of W-Sn skarn deposits.
Destrezas académicas y velocidad de procesamiento. Modelos predictivos del rendimiento escolar en básica primaria
Authors: Sánchez-Escudero Juan Pablo , Medina-Gómez Carolina , Gómez-Toro Yuliana
Published: June 2019

El modelo de inteligencia de Cattell-Horn-Carroll (CHC) propone que los procesos cognitivos que componen la inteligencia pueden conceptualizarse como habilidades específicas, implicadas en tareas particulares, y habilidades generales, relacionadas con una amplia cantidad de contextos. Entre las habilidades más estudiadas bajo este modelo se encuentra la velocidad de procesamiento, identificada como uno de los mejores predictores del rendimiento académico y de la capacidad cognitiva general. En este artículo se presentan los resultados del análisis de la relación entre la velocidad de procesamiento y rendimiento académico general. Se evaluó una muestra de 223 estudiantes (53% mujeres) de Preescolar y básica primaria. Los resultados muestran una diferencia en la capacidad predictiva del componente perceptual (β =.76, p < .001) y conceptual (β =.09; p = .121) de la velocidad de procesamiento en procesos académicos básicos de lectura y matemática, así como ajustes similares en modelos de regresión a partir de su conceptualización como habilidad general (R2 = .68) o específica (R2 = .69). El análisis de la relación grado a grado mostró cambios en la capacidad predictiva de la velocidad de procesamiento sobre las habilidades académicas conforme avanza el proceso educativo, apoyando modelos previamente establecidos en el área (Cai, Li & Deng, 2013; Demetriou, Spanodius & Shayer, 2014). Finalmente, es generó un modelo de ecuaciones estructurales (X2=1.431; p=.232; CFI=1.000; TLI=.999; NFI=.999; RFI=.996; RMSEA=.044) que permitió probar el ajuste de los modelos propuestos a los datos.
Informe herpetología para Ucayali, Perú - puntos base
Authors: Crnobrna Brian
Published: June 2019

Hay solo dos estudios formales enfocados en anfibios y reptiles del Valle Alto-Ucayali. Estos estudios tienen implicaciones afuera de solo el estudio de herpetología, tal como indicadores ambientales, áreas protegidas, y el uso sostenible de recursos naturales. A la fecha, el uso de búsquedas generales domina la metodología de herpetología en Ucayali, pero transectos también han sido ingresados. La variación de bosques, entre partes bajíos y el terreno firme, se explica gran parte de las diferencias en diversidad entre sitios, especialmente en los grupos de ranas venenosas (familia Dendrobatidae) y el género Osteocephalus. Un estimación a todas las especies registradas en el Valle Alto-Ucayali llega a solo 114 especies, indicando que un gran diversidad se queda para descubrir.Palabra claves: anfibios, reptiles, herpetología, Ucayali, monitoreo
Medicina tradicional o complementaria: pacientes que lo usan al mismo tiempo que su tratamiento farmacológico
Authors: García Richard
Published: June 2019

El objetivo del presente estudio fue determinar el consumo de productos alternativos y complementarios al mismo tiempo que su tratamiento farmacológico en pacientes que adquieren productos en farmacias y boticas de la ciudad de Chiclayo, para lo cual se aplicó un estudio transversal a 400 personas encontrando que el 52% de los pacientes lo hacen de los cuales solo el 6% de ellos lo comunican a su médico prescriptor. Además, casi el 100% de los encuestados manifestaron que vienen consumiendo o lo han hecho en algún momento de su vida, donde el 81% tienen educación superior.Palabras claves: Medicina alternativa complementaria, fitoterapia, medicinatradicional
Ética de la Función Pública y mejora de gestión pública del Gobierno Regional de Apurímac
Authors: Morales Eleuterio
Published: June 2019

Objetivo: El objetivo de la investigación es determinar la influencia del Código de Ética de la Función Pública en la mejora de la Gestión Pública de la sede central del Gobierno Regional de Apurímac 2018 Método: A través del método cuantitativo, de tipo básica, no experimental transversal de nivel descriptivo correlacional, se empleó una encuesta estadísticamente determinada por 132 servidores compuesto por personal nombrado y contratado, mediante un cuestionario estructurado validado por juicio de expertos y analizados mediante la fiabilidad de la escala Alpha de Cronbach. Para la comprobación de la hipótesis se utilizó el análisis de correlación Spearman mediante el software estadístico IBM SPSS, versión 22. Resultados: el 4.5% de encuestados expresan que siempre aplican el Código de Ética de la Función Pública y el 43.2% de encuestados manifiestan que casi nunca existe la mejora en la Gestión Pública y a través del coeficiente de correlación de Spearman a un nivel de confianza al 95% (sig = .00) de determina que existe una correlación positiva alta (r=0,899) entre el código de ética de la función pública y la mejora de la gestión , y correlación directa positiva alta (r=0,899) entre la dimensión de los principios éticos del servidor público y mejora de la Gestión Pública; correlación positiva muy alta (r=0,927) entre la dimensión de los deberes éticos del servidor público y mejora de la Gestión Pública ; una correlación positiva alta (r=0,898) entre la dimensión de las prohibiciones éticas del servidor público y la mejora de la Gestión Pública en la Sede Central del Gobierno Regional de Apurímac 2018. Conclusión: Existe una relación significativa entre código de ética de la función pública y la mejora la gestión pública, por lo tanto entonces es importante aplicar el código de ética para ofrecer servicios de calidad a los usuarios, y evitar la corrupción
Biochemical Indicators and Nitrates in Potatoes during Storage: Modern Cultivation Techniques
Authors: Бутов Алексей , Butov Alexey , Мандрова Анна , Mandrova Anna
Published: June 2019

It featured the dynamics of the biochemical parameters of potato tubers in the autumn and winter storage peri- od. The samples were gathered in 2011–2013 during field experiments. The experiments included 12 various doses and ratios of mineral fertilizers under drip irrigation. The soil was leached chernozem (Voronezh region). During 3 storage periods (Sep- tember–April), the content of vitamin C in moderately fertilized tubers decreased by 3.0–3.2 times. The content of vitamin C in heavily fertilized tubers decreased by 3.3–3.4 times. The loss of dry matter and starch at small and moderate doses of fertilizers N30-60P90-120K60-90 amounted to 1.4–1.5 and 1.0–1.1%. The loss of dry matter and starch from high doses of fertilizers N120-150P180-210K150-180 equaled 1.6–2.0 and 1.4–1.7%. The content of nitrates in the tubers gradually decreased during stor- age, and the greatest decrease occurred in April. For moderately fertilized tubers, the residual amount decreased by 3.2–3.3 times by April. For heavily fertilized tubers, it decreased by 2.5–2.9 times against 3.7 times in the control sample. Enhanced nitrogen and nitrogen-potassium fertilizer worsened all the biochemical indicators of the potatoes. In order to maintain optimal biochemical pa- rameters of tubers during storage, the proportion of phosphorus (kg/ha of active substance) had to be increased by 1.5–1.7 times as related to nitrogen. The share of potassium was increased by 1.3 times. The best results (yield = 37.8 t/ha, optimal biochemical pa- rameters, concentration of nitrates = 36.6 mg/%) were achieved by drip irrigation and application of N90P150K120 kg/ha of active ingredient. A dose of N120P180K150, (yield – 41.5 t/ha) was found beneficial, provided the potatoes were filled separately from the total pile. Such potatoes have to be sold at the end of the storage period, when the concentration of nitrates in tubers becomes 2.5– 2.9 times lower.
Syrups in Sugar Confectionery Products of High Nutritional Value
Authors: Резниченко Ирина , Reznichenko Irina , Фролова Нина , Frolova Nina , Кучебо Вачеслав , Kuchebo Vacheslav , Туров Семен , Turov Semen
Published: June 2019

Confectionery products of high nutritional value are affordable and rich in vitamins and minerals. Their development requires new raw materials with a high physiological value, which would be available on the local consumer market. Vegetable syrups can be used in sugar confectionery products, especially if they are fortified with vitamins and minerals. The present research proves the expediency of using fortified syrups in the production of sugar glasses. This type of caramel has a high energy value but no biologically valuable substances in the composition. Therefore, fortified syrups increase the biological value of the product. The study featured samples of sugar glasses with syrups fortified with rosehip, sea buckthorn, lemongrass, and cranberries. The paper describes their nutritional value, as well as the therapeutic and prophylactic properties of the syrups. It also contains data on the sensory quality, physic-chemical parameters, and the nutritional value.
Chemical and Bioactive Marine Natural Products of Coral-Derived Microorganisms (2015-2017)
Authors: Hou Xue-Mei , Hai Yang , Gu Yu-Cheng , Wang Chang-Yun , Shao Chang-Lun
Published: June 2019

:

Coral-derived microorganisms are known for their inherent ability to produce novel
products of pharmaceutical importance. Nearly 260 marine natural products (MNPs) have been isolated
from coral-derived microorganisms till 2014. In the last three years, 118 MNPs have been
isolated from coral-associated microorganisms including 46 new compounds, two with a novel
skeleton, and four new natural products. Most of them exhibited in vitro or in vivo activities against
tumor cell lines, parasites, pathogenic bacteria, fungi and virus. We reviewed the natural products
reported from 2015 to 2017 that have a wide range of bioactivities against different biological targets.
Hepatic Artery and Peripheral Vein Pharmacokinetics of Raltitrexed in Swine After the Administration of a Hepatic Arterial Infusion
Authors: Zhu Linzhong , Zheng Nan , Li Xingang , Zhang Xiaofeng
Published: June 2019

Background:

Hepatic Arterial Infusion (HAI) with raltitrexed has become an effective treatment for hepatocellular
cancer and colorectal cancer liver metastases. However, traditional Body Surface Area (BSA)-based dosing
is unsafe or ineffective, and a more accurate model-based approach is required.

Methods:

In this study, domestic swine were given 1 mg or 4 mg raltitrexed administered by an HAI with infusion
times of 30, 60 and 120 min. Hepatic Artery (HA) and Peripheral Vein (PV) samples were collected, and a twocompartment
model with an elimination pathway was established to describe the in vivo behavior of raltitrexed.

Results:

The clearance was 0.27 L/min, and the volumes of distribution were 0.35 and 6.65 L for the HA and PV
compartments, respectively. The goodness-of-fit plots and visual predictive checks suggested that the proposed
pharmacokinetic model agreed well with the observations.

Conclusion:

The pharmacokinetic model could be helpful in quantitatively describing the detailed processes of raltitrexed
activity administered by HAI and determining an appropriate dosing regimen for preclinical and clinical
studies.
Latent Tuberculosis Infection (LTBI) and Its Potential Targets: An Investigation into Dormant Phase Pathogens
Authors: Gutti Gopichand , Arya Karan , Singh Sushil Kumar
Published: June 2019

One-third of the world’s population harbours the latent tuberculosis infection (LTBI) with a
lifetime risk of reactivation. Although, the treatment of LTBI relies significantly on the first-line
therapy, identification of novel drug targets and therapies are the emerging focus for researchers across
the globe. The current review provides an insight into the infection, diagnostic methods and
epigrammatic explanations of potential molecular targets of dormant phase bacilli. This study also
includes current preclinical and clinical aspects of tubercular infections and new approaches in antitubercular
drug discovery.
Protease Inhibitors for the Treatment of HIV/AIDS: Recent Advances and Future Challenges
Authors: Voshavar Chandrashekhar
Published: June 2019

Acquired Immunodeficiency Syndrome (AIDS) is a chronic disease characterized by multiple life-threatening illnesses caused by a retro-virus, Human Immunodeficiency Virus (HIV). HIV infection slowly destroys the immune system and increases the risk of various other infections and diseases. Although, there is no immediate cure for HIV infection/AIDS, several drugs targeting various cruxes of HIV infection are used to slow down the progress of the disease and to boost the immune system. One of the key therapeutic strategies is Highly Active Antiretroviral Therapy (HAART) or ' AIDS cocktail' in a general sense, which is a customized combination of anti-retroviral drugs designed to combat the HIV infection. Since HAART’s inception in 1995, this treatment was found to be effective in improving the life expectancy of HIV patients over two decades. Among various classes of HAART treatment regimen, Protease Inhibitors (PIs) are known to be widely used as a major component and found to be effective in treating HIV infection/AIDS. For the past several years, a variety of protease inhibitors have been reported. This review outlines the drug design strategies of PIs, chemical and pharmacological characteristics of some mechanism-based inhibitors, summarizes the recent developments in small molecule based drug discovery with HIV protease as a drug target. Further discussed are the pharmacology, PI drug resistance on HIV PR, adverse effects of HIV PIs and challenges/impediments in the successful application of HIV PIs as an important class of drugs in HAART regimen for the effective treatment of AIDS.
Active Subfractions, Phytochemical Constituents, Dipeptidyl Peptidase-IV Inhibitory Activity and Antioxidant of Leaf Extract from Hibiscus surattensis L.
Authors: Yuliet  , Sukandar Elin Y. , Adnyana I.K.
Published: June 2019

Objective:

This research aimed to investigate the mechanism of action of leaf extract and
active subfraction from English wild sour or Hibiscus surattensis L., evaluating antioxidant activity,
and determining phytochemical constituents potential for treating various ailments such as diabetes
and hepatitis.

Background:

Antioxidant potential of ethanolic extracts of leaf and active subfractions (ethyl acetate
and water fraction) were evaluated using 2,2-diphenyl-1-picrylhydrazyl, Ferric Reducing Ability
of Plasma and Cupric Reducing Antioxidant Capacity assays.

Methods:

Analysis of total flavonoid and phenolic contents were expressed as Quercetin Equivalent
and Gallic Acid Equivalent through spectrophotometric technique. Liquid Chromatography-Mass
Spectrophotometry/Mass Spectrophotometry was used to identify phytochemical constituents.

Results:

The results showed that the ethyl acetate fraction was potentially inhibitory against dipeptidyl
peptidase IV (IC50 17.947 ± 4.842μg/mL) and had a high free radical scavenging capacity (IC50
value of 44.10 ± 0.243μg/mL; Ferric Reducing Ability of Plasma and Cupric Reducing Antioxidant
Capacity values were found to be 639.70 ± 0.3mg ascorbic acid equivalent/g and 174.89 ± 0.58mg
ascorbic acid equivalent/100 g respectively). Ethyl acetate fraction showed high flavonoid and phenolic
content with 684.67 ± 0.83mg Quercetin Equivalent/g and 329.23 ± 0.82mg Gallic Acid
Equivalent/g. Liquid Chromatography-Mass Spectrophotometry/ Mass Spectrophotometry analysis
showed the presence of major compounds, including kaempferol, morin, quercetin, and trifolin.

Conclusion:

These results may explain the use of these leaves in folk medicine in the control of diabetes
through a new mechanism and by preventing diabetic complications by means of their antioxidant
properties.
Design, Development and Comparison of Heuristic Driven Algorithms Based on the Crossed Domain Products’ Reviews for User’s Summarization
Authors: Ahmad Sartaj , Gupta Ashutosh , Gupta Neeraj Kumar
Published: June 2019

Background:

In recent time, people love online shopping but before any shopping feedbacks or reviews always required. These feedbacks help customers in decision making for buying any product or availing any service. In the country like India this trend of online shopping is increasing very rapidly because awareness and the use of internet which is increasing day by day. As result numbers of customers and their feedbacks are also increasing. It is creating a problem that how to read all reviews manually. So there should be some computerized mechanism that provides customers a summary without spending time in reading feedbacks. Besides big number of reviews another problem is that reviews are not structured.

Objective:

In this paper, we try to design, implement and compare two algorithms with manual approach for the crossed domain Product’s reviews.

Methods:

Lexicon based model is used and different types of reviews are tested and analyzed to check the performance of these algorithms.

Results:

Algorithm based on opinions and feature based opinions are designed, implemented, applied and compared with the manual results and it is found that algorithm # 2 is performing better than algorithm # 1 and near to manual results.

Conclusion:

Algorithm # 2 is found better on the different product’s reviews and still to be applied on other product’s reviews to enhance its scope. Finally, it will be helpful to automate existing manual process.
Microwave-assisted One-pot Synthesis of 2-Substituted Quinolines by Using Palladium Nanoparticles as a Catalyst developed from Green Alga Botryococcus braunii
Authors: Arya Anju , Mahajan Akhil , Chundawat Tejpal Singh
Published: June 2019

Background:

Quinoline is a type of N-based organic heterocyclic biologically active compound. Quinolines have grasped the interest of scientists because of their wide scope of applications. Several methods have been developed for the synthesis of quinoline and its derivatives. In this study, a new, efficient, simple, one-pot synthesis of the substituted quinolines was developed by using palladium nanoparticles as a catalyst.

Methods:

Catalyst synthesized by algal extract of green alga Botryococcus braunii and palladium acetate solution, and characterized by different instrumental techniques like FTIR, SEM, and XRD. The synthesized palladium nanoparticles explored for the catalytic activity in the synthesis of quinoline derivatives by the use of 2-aminobenzyl alcohol in toluene with acetyl derivatives followed by the addition of potassium hydroxide. The formation of the product was confirmed by 1HNMR, 13C NMR, and electron ionization mass spectra.

Results:

The formation of palladium nanoparticles characterized by visual observation means the color change from light pale yellow to dark brown indicates the reduction of palladium ions into palladium nanoparticles. Synthesized palladium nanoparticles characterized by FTIR spectrum of the algal extract of green algae B. braunii for the presence of proteins, lipids, carbohydrates, carotenoids, vitamins and other secondary metabolites in algal extract, which function as active components for bioreduction. The morphology of the catalyst was confirmed by SEM and X-ray diffraction measurements for shape, crystalline nature and size. The synthesized palladium nanoparticles explored for the catalytic activity in the synthesis of quinoline derivatives by use of 2-aminobenzyl alcohol in toluene and added acetyl derivatives followed by the addition of potassium hydroxide. In order to establish the optimum heating method, a comparative study between conventional and microwave heating method was carried out in the presence of palladium nanoparticles as a catalyst.

Conclusion:

This protocol provides a convenient and practical procedure for the preparation of quinoline derivatives from 2-aminobenzyl alcohol, acetyl derivatives, potassium hydroxide and palladium nanoparticles as a catalyst. This protocol will be helpful in synthesizing other quinoline derivatives and several organic heterocycles which are used in different fields such as biological, industrial, pharmaceutical, chemical, medical, etc.
Withdrawn: Aqueous Extract of Eucalyptus Camaldulensis Leaves as a Reducing and Capping Agent in Green Synthesis of Silver Nanoparticles
Authors: Alghoraibia I. , Soukkarieh Ch. , Zein R. , Alahmad A. , Walter J-G. , Daghestani M.
Published: June 2019

The article entitled, “Aqueous Extract of Eucalyptus Camaldulensis Leaves as a Reducing and Capping Agent in Green Synthesis
of Silver Nanoparticles” submitted in Current Nanomaterials (CNM) by Dr. Ibrahim Alghoraibi has been withdrawn from
the journal in accordance with BSP Editorial Policies.
Chewing Gum Use in the Perioperative Period
Authors: Doyle D. John
Published: June 2019

A synopsis of the latest research on the perioperative use of chewing gum by surgical patients is presented, focusing on the preoperative and postoperative periods. Current data now suggest that the preoperative use of chewing gum does not adversely affect gastric emptying and that the postoperative use of chewing gum may actually aid recovery from some forms of major surgery. Additionally, the use of chewing gum may increase alertness and serve to reduce stress, as well as offer important oral health benefits.
Credit Constraints and Investment in Mexico, an Empirical Test
Authors: Gómez-Ramírez Leopoldo
Published: June 2019

Despite the vast overhaul the Mexican economy has gone through since the 1980s, the promised high and sustained economic growth has not materialized. Scholars and policy makers are unanimous in pointing to credit constraints as one of the key reasons for the disappointing growth performance. The link between financial restrictions and investment decisions, however, has not been solidly verified in the Mexican literature. This paper intends to start filling this lacuna. Using recent microeconomic, firm-level data which is reasonably nationally representative, it tests the hypothesis that credit constraints have reduced investment among Mexican firms. Consistent with the general thrust of the literature, it is found that indeed financial restrictions have reduced the investment carried out by Mexican firms. The result holds under different econometric estimations.
Evaluación de riesgos con Data Mining: el sistema financiero español
Authors: Fernández Fernández José Alejandro , Bejarano Vázquez Virginia , Vicente Virseda Juan Antonio
Published: June 2019

El objetivo de este trabajo, basado en técnicas de Data Mining, es llegar a identificar el mejor método de predicción de riesgos para el sistema bancario español, teniendo en cuenta tanto sus características específicas, como la situación económica de España en el período objeto de estudio. Para ello, se definen, en primer lugar, catorce ratios que permiten identificar, en términos de riesgos, la situación de los bancos y cajas de ahorros españoles durante el período examinado. Mediante una técnica de reducción de dimensiones con la que se simplifica la interpretación de resultados, se obtienen cuatro factores latentes sobre los que se evalúa, junto con cuatro variables macroeconómicas adicionales,un conjunto de algoritmos de Data Mining, siendo seleccionado finalmente el arbol CHAID, a diferencia de trabajos previos, en los que nunca se había llegado a proponer la aplicación de técnicas de Data Mining y Machine Learning en la identificación de situaciones de riesgo en la industria bancaria española. Una limitación de este trabajo ha sido la imposibilidad de incorporar variables regulatorias, por tratarse de información reservada que, de haber estado disponible, nos habría permitido incorporar una nueva dimensión en la predicción de riesgos.