bluuebunny/crossref_metadata_2025 huggingface dataset:
The Per(ver)formative Aspects of Pandemic Fashion Performances: Moschino’s Deconstructive Marionettes
Authors: Egri Petra
Published: November 2022

It is said that due to the social and economic effects of the recent pandemic, fashion has been caught in a destructive position. One aspect is the material change of the fashion objects and the strong pre-eminence of the so-called “stay-at-home collections” against the earlier dominance of the ready-to-wear and haute couture garments intended for social events. An important feature of recent fashion changes is their reliance on current pandemic rules and the related political decisions. In my presentation, I will focus on an interesting example of these pandemic changes: Moschino’s 2021 Spring/Summer Collection. Moschino’s “Marionette Performance” is a perfect example for infelicitous performativity where the show is created in a per(ver)formative (in the Derridean sense) act in the catwalk space. I intend to show that performativity is broken at every step of the show. In this spring collection, not only are the mannequins substituted by dolls but the viewers – some are well known (e.g. Anna Wintour) – are also transformed into marionettes by Jeremy Scott. With a self-ironic gesture, anyone of us from the possible audience can be changed into a puppet. To analyse the performative character of the show, I use deconstructive approaches and ideas. I wish to emphasize the interweaving performative dimensions that, in a sense, preclude each other with the help of Paul de Man’s interpretation of Kleist’s Über das Marionettentheater. I want to point out the mechanical, meaningless materiality appearing in the marionettes’ movements on Moschino’s special catwalk. My lecture argues that in the movements of the marionettes the possibility of the clear manifestation of performativity becomes uncertain.
Liquid Wardrobes and Sensing: A Phenomenological Approach to Digital Perfume Communities
Authors: Virginás Péter
Published: November 2022

The fact that perfumes have been regarded as enhancing one’s appearance opens up questions about knowing and wearing fragrances. The connections between fragrances and fashion are being reviewed first according to the notion of embodiment as applied to the understanding of clothing fashion (Entwistle 2000, 2015); then, the lens of “mediatization”, as applied by Rocamora (2017) to grasp the contemporary entanglement of fashion and digital media, further serves to turn to digital perfume communities. These constitute an essential resource to the extent that they share experiences while producing data about wearing and collecting fragrances. By tracing the recent insurgence of perfume criticism and by mapping certain techniques of entering into relation with fragrances through community members’ perfume reviews as well, the study argues that their idiosyncratic and often artistic language is countering the impersonal language of perfume advertising; ultimately, the study suggests unravelling perfume consumption patterns via an aesthetics of attention.
Variability of soil properties with fire severity in pine forests and reforested areas under Mediterranean conditions
Authors: Lucas-Borja Manuel Esteban , Fernández Cristina , Plaza-Alvarez Pedro Antonio , Carrà Bruno Gianmarco , Zema Demetrio Antonio
Published: November 2022

It is well known how fires affect the properties of forest soils depending on its severity. A better understanding of the magnitude of these impacts is essential to setup effective management actions after fire against the losses of soil and biodiversity. However, physical, chemical and biological processes in burnt soils are complex, resulting in a diversity of fire-induced changes, as acknowledged in many literature studies. Moreover, these changes may be even variable between natural forests and reforested areas. This study explores the changes in the most important soil properties with fire severity, from low to high. The main chemical parameters of soils were measured after field sampling in different pine forests (burnt natural stands, reforested areas as well as unburnt sites) of Castilla La Mancha (Central Eastern Spain). In comparison to the unburnt soils, the investigation has shown in the burnt areas: (i) no evident changes in soil pH at all fire severities, except in natural stands burnt at a very high severity (showing an increase of about 10%); (ii) increases in the organic carbon content (by about 70%) of soils burnt at a moderate fire severity under both forest ecosystems, and in reforested areas at very high fire severities (+95%); (iii) small differences in the nitrogen content of soil, except for a significant increase measured in soils burnt at an moderate fire severity under both the natural pine stand and reforested area (about +300%); (iv) a limited variability of the phosphorous content in the soil, with only an increase in soils under natural pine stands burnt at moderate fire severity (by 250%); (v) increases in magnesium and potassium contents in soils burnt at the highest fire severities for both land conditions, and decreases in calcium content in reforested areas burnt at the highest severity. Due to some negative impacts (increase in pH and decrease in organic carbon), the implementation of post-fire management actions at natural pine stands burnt at the highest fire severity should be a priority over reforested areas. Overall, this study did not show a straightforward pattern between soil properties, fire severity and land condition. This means that other parameters (for instance, the hydrological properties of soils) that were not explored in this investigation could have played an important role, and therefore must be taken into consideration when defining post-fire management actions.
Metformin as a Potential Antitumor Agent
Authors: Petrovic Andjela , Markovic Vladimir , Maric Veljko , Gajovic Nevena
Published: November 2022

Some recent findings suggest that metformin, an oral antidiabetic drug, may have antitumor properties. Studies have shown that metformin can alter cell metabolism, both tumor and immune cells, which can greatly influence disease outcome. In this review, we discuss the potential mechanisms in which metformin can directly induce apoptosis of tumor cells as well as mechanisms in which metformin can elicit or enhance antitumor immune response.
CO2 Emission Costs Due to the Production and Use of Vehicles in the Context of Automotive Development
Authors: Wiśniowski Piotr , Borucka Anna , Menes Maciej , Świderski Andrzej
Published: November 2022

The aim of this article is to assess the carbon dioxide (CO2) emissions of three types of cars: two internal combustion cars and one Fuel Cell Electric Vehicle (FCEV), measured on the basis of type approval regulations.

The article also assesses the CO2 emission costs resulting from the production of fuel and the production of the car.

It was assumed as a research hypothesis that the development and growing serial production of vehicles with different power systems will bring measurable changes in CO2 emissions from road transport. Based on their own research, the authors also analyzed the credibility of the assumptions made about the benefits related to emissions resulting from replacing the classic vehicle with hydrogen one. They estimated the duration and intensity of use of a hydrogen vehicle that offers CO2 benefits compared to a conventional vehicle.
Back Matter
Authors: Muljono Pudji
Published: November 2022

Jurnal Penyuluhan Edisi 18 (2): Maret 2022
The Role of Myocutaneous Flaps in the Treatment of Patients with Multiple Decubitus Ulcers
Authors: Gheorghe Bejinariu Catalin ,   Department of Plastic and Reconstructive Surgery, “Bagdasar-Arseni” Emergency Clinical Hospital, Bucharest, Romania,   Catalin Gheorghe Bejinariu, Department of Plastic and Reconstructive Surgery, “Bagdasar-Arseni” Emergency Clinical Hospital, 12 Soseaua Berceni, 041915, Bucharest, Romania, Phone: +40724572908, E-mail: drbejinariu@gmail.com,   Department of Plastic and Reconstructive Surgery, “Bagdasar-Arseni” Emergency Clinical Hospital, Bucharest, Romania, Adrian Marinescu Silviu
Published: November 2022

The current research aims to present the therapeutic approach in the case of a paraplegic patient hospitalized in the Plastic Surgery Department at the “Bagdasar-Arseni” Emergency Clinical Hospital for the treatment of decubitus ulcers located at the level of the sacral, left trochanteric and posterior thoracic regions. The particularity of the case is given by the complexity of the surgical interventions necessary for the reconstruction of the above-mentioned anatomical regions. In order to cover the sacral region, two gluteal myocutaneous flaps were used, followed by a tensor fascia lata flap for the trochanteric lesion. For the thoracic defect, the surgical team has chosen the technique of excision and direct suture. Following reconstructive surgery, the patient had a favorable local evolution, being included in an intensive medical recovery program within the same health unit.
Lower Limb Salvage Using the Medial Hemisoleus Flap Associated with the Reverse Sural Flap
Authors: Gheorghe Bejinariu Catalin ,   Department of Plastic and Reconstructive Surgery, “Bagdasar-Arseni” Emergency Clinical Hospital, Bucharest, Romania,   Catalin Gheorghe Bejinariu, Department of Plastic and Reconstructive Surgery, “Bagdasar-Arseni” Emergency Clinical Hospital, 12 Soseaua Berceni, 041915, Bucharest, Romania, Phone: +40724572908, Email: drbejinariu@gmail.com, Adrian Marinescu Silviu ,   Department of Plastic and Reconstructive Surgery, “Bagdasar-Arseni” Emergency Clinical Hospital, Bucharest, Romania
Published: November 2022

The paper aims to present the reconstructive surgical approach in the case of a patient with complex soft tissue lesions of the calf. The patient was the victim of a road accident resulting in the fracture of the right tibia for which screw-plate osteosynthesis was performed. The chosen therapeutic solution was represented by covering the soft tissue defects using a complex algorithm that involved the use of a reverse sural flap associated with a medial hemisoleus muscle flap and a split-thickness skin graft.

Considering functional recovery and the degree of patient satisfaction, the result of the therapeutic conduct was appreciated as very good. The association of the reverse sural flap with the medial hemisoleus flap can be a solution for solving complex cases with multiple soft tissue defects located in the middle and lower third of the calf.
Respiratory Outcome of the Former Premature Infants
Authors: Daniela Bogdan Raluca ,   Medicover Hospital, Bucharest, Romania, Rusu Lidia ,   Regional Center of Public Health, Iasi, Romania, Ioan Toma Adrian ,   Life Memorial Hospital , Bucharest, Romania,   Adrian Ioan Toma, Life Memorial Hospital, Calea Grivitei no. 365, district 1, Bucharest, Romania, Phone: +40756565670, E-mail: atoma@medlife.ro, Nastase Leonard ,   Alessandrescu - Rusescu National Institute of Mother and Child Health, Bucharest, Romania
Published: November 2022

The research aims to identify the respiratory pathology during the first two years of life in premature infants with gestational ages between 30-34 weeks and the risk factors for these conditions (familial, prenatal, and neonatal).

There were investigated 31 premature infants with gestational ages between 30-34 weeks and the incidence of bronchopulmonary dysplasia, infections with the respiratory syncytial virus, or other viral infections requiring hospitalization, recurrent wheezing, and nasal colonization with pathogenic bacteria were noted. Also, regression models for each type of respiratory pathology as a function of the antenatal (smoking in the family, atopy, mother’s age) and neonatal (gestational age, respiratory distress syndrome, duration of the treatment with antibiotics, use of the reserve antibiotics) factors were elaborated.

Respiratory distress syndrome was present in 20 premature infants, and 19 infants received respiratory support. Two former premature infants presented with bronchopulmonary dysplasia, 3 with severe respiratory syncytial virus infections, 7 with recurrent wheezing, and 16 with viral infections requiring hospitalization. Respiratory distress syndrome and severe viral infections were more frequently found in families of smokers. Low gestational age and familial atopy were identified as good predictors of severe respiratory syncytial virus infections (p< 0.03)

Premature infants with gestational ages between 30-34 weeks present with the risk of appearance of respiratory diseases during the first two years of life, especially disorders of the airways. Familial atopy and low gestational age represent independent risk factors for severe respiratory syncytial virus infections.
SIMULASI MODEL NAVIGASI MOBILE ROBOT DENGAN PENERAPAN METODE CONTROL LYAPUNOV-BARRIER FUNCTION (CLBF) TERHADAP SISTEM NAVIGASI WAYPOINT
Authors: Romdlony Muhammad Zakiyullah , Fachri Ridlho Khoirul , Rosa Muhammad Ridho
Published: November 2022

Simulasi menjadi bagian penting dalam keberhasilan implementasi metode kontrol sebelum diterapkan pada real plant. Paper ini membahas implementasi metode Control Laypunov-Barrier Function (CLBF) pada model navigasi mobile robot terhadap sistem navigasi waypoint melalui simulasi Matlab. CLBF merupakan kombinasi metode Control Lyapunov Function (CLF) dan Control Barrier Function (CBF) yang memiliki peran untuk menjaga kestabilan dan menjamin keselamatan pada sistem. Pemberian tiga waypoint sebagai navigasi gerak dari model mobile robot berfungsi untuk mengetahui kestabilan sistem, tiga barrier berbentuk lingkaran untuk area yang harus dihindari, dan unsafe state diberikan supaya model navigasi mobile robot tidak menabak barrier, sehingga sistem dikatakan aman. Simulasi yang dilakukan memperlihatkan model navigasi mobile robot yang mampu bergerak menuju beberapa waypoint dengan menghindari tiga barrier dalam waktu yang berbeda, di antaranya dari initial state ke waypoint pertama membutuhkan waktu 7,43 detik, dari waypoint pertama ke waypoint kedua membutuhkan waktu 5,73 detik, dan dari waypoint kedua ke waypoint ketiga membutuhkan waktu 6,75 detik. Penempatan waypoint, barrier, dan unsafe state terhadap bidang dua dimensi yaitu x1 sebagai koordinat x danx2 sebagai koordinat y.

Kata Kunci: control lyapunov-barrier function, simulasi, waypoint
Manejo da asma infantil: uma revisão narrativa
Authors: Alves Ana Karen de Sousa , Abreu Victórya Suéllen Maciel , Veras Alessandra Lima de Carvalho Gurgel , Carvalho Sarah de Sousa , Rodrigues Hillary Bastos Vasconcelos , Freitas Bruna Barroso de , Nascimento Anne Santiago do , Oliveira Raquel Alves de , Lima Rayanne Branco dos Santos , Barbosa Lorena Pinheiro
Published: November 2022

Objetivo: Relatar dados relevantes sobre a asma na infância a fim de possibilitar o conhecimento sobre a doença, visto sua prevalência e importância no Brasil e no mundo. Revisão bibliográfica: A asma é uma doença crônica caracterizada pela inflamação duradoura das vias aéreas. Em se tratando dos fatores de risco, tem-se que por ser uma doença multifatorial, uma série de variáveis influenciam o desfecho do seu acometimento, como os fatores ambientais, pessoais e genéticos. No que concerne a fisiopatologia, é uma condição imunomediada por reações de hipersensibilidade envolvendo a Imunoglobulina E (IgE), a qual desencadeará uma cascata de reações inflamatórias que levam a degranulação de mastócitos e, consequentemente, a uma resposta patológica exacerbada afetando o fluxo aéreo de forma reversível, podendo ter amplo componente genético. Ademais, a farmacoterapia é dividida em dois grupos, o de medicamentos destinados à manutenção do fluxo aéreo regular e os de manejo sintomático. Considerações finais: A presente revisão narrativa apresentou o cenário atual dos estudos referentes à asma na infância, empenhando-se para contribuir com o conhecimento científico sobre os aspectos estudados nesse público até o momento.
Reabilitação multiprofissional pós-Covid: revisão de escopo
Authors: Silva Vitória Polliany de Oliveira , Ribeiro Kátia Suely Queiroz Silva , Carneiro Lucilla Vieira , Lemos Silvia Niedja de Sousa Farias , Nogueira Rafaela Raulino , Carneiro Hellen Maria Lacerda de Oliveira , Oliveira Cecília Danielle Bezerra , Araújo Gabriela Carlos Ribeiro , Coelho Hemílio Fernandes Campos
Published: November 2022

Objetivo: Verificar as evidências científicas acerca da reabilitação multiprofissional pós-Covid. Métodos: Trata-se de uma revisão de escopo, realizada em maio de 2022 com buscas na Biblioteca Virtual de Saúde (BVS) e National Library of Medicine (PubMed). Os critérios de inclusão foram: estudos com os mais variados delineamentos metodológicos, que abordassem qualquer tipo de reabilitação pós-Covid implementada aos pacientes que apresentaram sequelas; sem restrição de idioma; publicados entre 2020 e 2022. Foram excluídos artigos duplicados e que não responderam à questão de pesquisa. Resultados: A amostra do estudo foi composta por 6 artigos, publicados principalmente no ano de 2021. A partir do levantamento realizado, foi possível identificar que dentre os profissionais de saúde envolvidos na reabilitação pós-Covid destacam-se os fisioterapeutas, que atuam ativamente na busca da recuperação da função respiratória e motora dos indivíduos. Entretanto, com a diversidade de sequelas físicas, cognitivas e psicológicas que a Covid-19 pode ocasionar, outros profissionais de saúde também se apresentam atuantes neste processo. Considerações finais: A reabilitação multiprofissional pós-Covid é um componente-chave para a reinserção social dos indivíduos sequelados.
Aquagenic Urticaria in an Adolescent Following COVID-19 Vaccine
Authors: Broderick John , Selby Thomas , Trevino Julian
Published: November 2022

A subset of patients receiving COVID-19 vaccinations develops cutaneous reactions. The majority are delayed hypersensitivity reactions that resolve spontaneously without treatment. More rarely, cutaneous manifestations such as urticaria, vasculitis, and morbilliform eruptions have been reported. Aquagenic urticaria is a form of chronic inducible urticaria caused by skin contact with water. Characteristic 1-2mm folliculopapular urticarial papules appear 20-30 minutes following water exposure and spontaneously resolve within 30-60 minutes of water removal. A water provocation test is the gold standard of diagnosis. The mainstay of treatment is 2nd generation H1 antihistamines taken before water exposure. We report the development of aquagenic urticaria in a 12-year-old African American male patient following the Pfizer-BioNTech mRNA COVID-19 vaccine.
Interim Clinical Utility Findings of a Transcriptomic Psoriasis Biologic Test Demonstrate Altered Physician Prescribing Behavior and Improved Patient Outcomes
Authors: Strober Bruce , Bukhalo Michael , Armstrong April , Pariser David , Kircik Leon , Parhami Sepideh , Montgomery Paul , Dickerson Tobin
Published: November 2022

Objective: This study (MATCH) was designed to assess the clinical utility of a machine-learning based tool (Mind.Px) that predicts patient response to the most common biologic drug classes used in the management of psoriasis patients.

Methods: The MATCH study was designed to assess Mind.Px utility in physician decision making and patient outcomes. Psoriasis patients who were biologic naïve or those who were approaching a change due to non-response were enrolled into the study (N=112). At baseline, a dermal biomarker patch was applied to lesional skin and Mind.Px test results were provided to physicians prior to biologic selection. The choice of biologic for each patient was recorded and in the case of physician non-concordance with Mind.Px test results, a questionnaire completed to determine the reason for non-concordance. Patients were evaluated at weeks 4, 8, 12, and 16 after baseline using PASI, PGA, and BSA. Statistical analysis between groups was performed using Fisher’s exact test.

Results: Physician prescribing behavior was measured with and without the inclusion of Mind.Px test results in the decision-making process. This data set was compared to a previously obtained data set in which dermal biomarker patches were applied at baseline, but Mind.Px results were not provided to physicians at any point during treatment (N=180). Statistical analysis of concordance between the Mind.Px-informed and Mind.Px-uninformed groups within the MATCH study (84.4% vs 53.8%, respectively) showed that when given access to Mind.Px results, physician behavior was significantly altered (p = 0.0022). Furthermore, analysis of those patients who have completed the study showed improved clinical outcomes in those patients whose physicians were provided Mind.Px test results. Specifically, this cohort reached PASI75 sooner than those who were not provided test results (p = 0.004).

Conclusion: These results provide an interim measurement of the clinical utility of Mind.Px by demonstrating that physicians will utilize this test in psoriasis biologic decision making and by doing so, this leads to improved patient outcomes. These improved patient outcomes can also potentially translate into tremendous cost savings for healthcare systems. Mind.Px can effectively minimize the trial-and-error approach to psoriasis treatment, and provide physicians, patients, and payers with a powerful tool for improving psoriasis patient management.
Severity of COVID-19 in Patients with Dermatomyositis: A Single Center, Retrospective Observational Cohort Study
Authors: Johnson Jessica , Nowacki Amy , Narang Jatin , Young Sarah , Fernandez Anthony P.
Published: November 2022

Although dermatomyositis (DM) patients have been included in studies evaluating for COVID-19 risk and severity in large cohorts of chronic immune mediated disease patients, there have been few studies looking specifically at cohorts of DM patients. We performed a single-center, retrospective cohort study of DM patients seen at the Cleveland Clinic who were diagnosed with COVID-19 via PCR test between March 2020 – July 2021.  To assess for risk factors for severe COVID-19 disease course in the DM patient population, we utilized several characteristics known to impact COVID-19 disease course including age, BMI, and medications at time of diagnosis. We additionally included characteristics unique to the DM patient population including DM subtype and autoantibody status.  Our results showed that risk factors for COVID-19 hospitalization in our DM cohort include age, BMI, and systemic medication use at time of COVID-19 infection.  Despite our small sample size, our study is one of the first to elucidate characteristics important for COVID-19 disease course in DM specifically, rather than having it grouped alongside other disease processes. Awareness of this risk is important for clinicians caring for DM patients in order to optimize their care and protect them from a severe COVID-19 disease course.
Oral Nalbuphine Extended-Release Is Effective in Severe Prurigo Nodularis–Associated Pruritus: Results From a Phase 2b/3, Double-Blind, Placebo-Controlled Study
Authors: Ständer Sonja , Weisshaar Elke , Parish Jennifer L , Szepietowski Jacek C , Reich Adam , Korman Neil J , Bortey Enoch , Sciascia Thomas R
Published: November 2022

N/A
Patient Perspectives on the Prevalence and Burden of Psoriasis: Results From a National Survey of Adults With Psoriasis in the United States
Authors: Armstrong April W , Young Melodie , Seal Melissa , Higham Robert , Greiling Teri
Published: November 2022

N/A
Improving Patient Acceptability and Adherence in Psoriasis Treatment
Authors: Curcio Alyssa , Kontzias Christina , Feldman Steven R
Published: November 2022

N/A
Optimizing the treatment sequence: the cumulative clinical benefit of treatment initiation with deucravacitinib versus apremilast over 52 weeks in patients with moderate to severe plaque psoriasis from the POETYK PSO-1 trial
Authors: Armstrong April W , Hee Park Sang , Chirikov Viktor , Nicolas Pierre , Wang Wei-Jhih , Colombo Matthew J , Patel Vardhaman
Published: November 2022

N/A
Bimekizumab versus secukinumab continuous maintenance of response at every visit through one year in patients with moderate to severe plaque psoriasis: Post-hoc results from the BE RADIANT phase 3b trial
Authors: Warren RB , Conrad C , Foley P , Iversen L , Langley RG , Kokolakis G , Davis L , Vanvoorden V , Wiegratz S , Merola JF
Published: November 2022

N/A
Maintenance of bimekizumab efficacy through 2 years in patients with moderate to severe plaque psoriasis: Pooled results from five phase 3/3b trials
Authors: Thaçi D , Armstrong A , Lebwohl M , Blauvelt A , Paul C , Puig L , Wang M , Vanvoorden V , Madden C , Wiegratz S , Deherder D , Gordon KB
Published: November 2022

N/A
Efficacy and safety of up to two years of tralokinumab treatment in adults of different racial subgroups with moderate-to-severe atopic dermatitis
Authors: Mayo Tiffany , Armstrong April W , Kircik Leon , Silverberg Jonathan , Blauvelt Andrew , Esdalie Ben , Schneider Shannon , Mark Thomas , Gooderham Melinda , Alexis Andrew F
Published: November 2022

N/A
A CLINICAL CASE OF SEVERE COVID-19 INFECTION IN A PUERPERANT IN THE EARLY POSTPARTUM PERIOD USING EXTRACORPOREAL MEMBRANE OXYGENATION
Authors:   Grodno State Medical University, Grodno, Belarus, Yakubtsevich R. E. , Yanushko A. V. ,   Grodno Regional Clinical Cardiology Center, Grodno, Belarus, Balla A. A. ,   Grodno University Clinic, Grodno, Belarus, Zukhovitskaya E. V. ,   Grodno State Medical University, Grodno, Belarus, Grib S. N. ,   Grodno Regional Clinical Cardiology Center, Grodno, Belarus, Sanko O. E. ,   Grodno Regional Clinical Cardiology Center, Grodno, Belarus, Ganchar E. P. ,   Grodno State Medical University, Grodno, Belarus, Kyzmich I. I. ,   Grodno Regional Clinical Perinatal Center, Grodno, Belarus, Rakashevich D. N. ,   Grodno State Medical University, Grodno, Belarus
Published: November 2022

A new coronavirus infection (COVID-19) raises reasonable concerns about the impact of the Sars-CoV-2 virus on pregnant women and women in the postpartum period, given the high risk of COVID-19-associated acute respiratory distress syndrome with refractory hypoxemia, even against the background of artificial lung ventilation. When this situation arises, the use of Extracorporeal membrane oxygenation (ECMO) is justified to improve respiratory function and support blood circulation. In the given clinical case, the experience of successful treatment of a patient with COVID-19 infection in the early postpartum period with ECMO for 22 days, who was hospitalized at the Grodno Regional Clinical Cardiology Center, is presented. In the current clinical situation, all methods of respiratory support have been consistently used: from oxygen therapy through high-flow ventilation and non-invasive mechanical ventilation, to invasive mechanical ventilation. During her stay on ECMO, the patient experienced two hemorrhagic events that required surgical interventions. During therapy, it was possible to avoid thrombosis of the circuit and prevent the development of rebleeding against the background of anticoagulant therapy by carefully monitoring the hemostasis system using clotting hemostasiological tests and ROTEM indicators and correcting their violations.
VLADIMIR IVANOVICH DAL – THE DOCTOR WITH THE WORD (TO THE 150TH ANNIVERSARY OF DEATH)
Authors:   Grodno State Medical University, Grodno, Belarus, Khilmonchik N. E.
Published: November 2022

The article is devoted to the medical activity of the great creator of the Russian dictionary V.I.Dal. Many of us are well aware of the merit of V.I. Dal before Russian literature, but only the true experts of his work are aware of the undoubted abilities of Vladimir Ivanovich in the field of medicine. Meanwhile, in the biography of V.I. Dahl has a lot of bright moments confirming his undoubted contribution to the development of medicine as a scientist and as a practicing doctor.
Polymeric architecture as a tool for programming sequential enzyme-induced mesophase transitions
Authors: Rathee Parul , Edelstein-Pardo Nicole , Sitt Amit , Amir Roey J.
Published: November 2022

Di- and tri-block amphiphiles can form different mesophases ranging from micelles to hydrogels depending on their chemical structures, hydrophilic to hydrophobic ratios, and their ratio in the mixture. In addition, their different architectures dictate their exchange rate between the assembled and unimer states, and consequently affect their responsiveness towards enzymatic degradation. Here we report the utilization of the different reactivities of di- and tri-block amphiphiles towards enzymatic degradation as a tool for programming formulations to undergo three sequential enzymatically induced transitions from: (i) micelles to (ii) hydrogel and finally to (iii) dissolved polymers. We show that the rate of transition between the mesophases can be programmed by changing the ratio of the amphiphiles in the formulation, and that the hydrogels can maintain encapsulated cargo, which was loaded into the micelles. The reported results demonstrate the ability of molecular architecture to serve as a tool for programming smart formulations to adopt different structures and functions.
Dyad orientation-dependent regulation of SARS-CoV 2 protease: towards informed structure-based drug discovery
Authors: Abdel-Maksoud Khaled , al-Badri Mohamed Ali , Lorenz Christian , Essex Jonathan
Published: November 2022

NOTE - A significant portion of the text from this preprint is drawn from a previous submission (https://doi.org/10.26434/chemrxiv.12967655.v2). This is a later version of the previous submission with a new title and updated results. The Coronavirus Disease of 2019 (COVID-19) is caused by a novel coronavirus known as the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV 2). The main protease (MPro) of SARS-CoV 2 mediates viral replication through proteolytic activity and the subsequent generation of infectious virus particles. Current computational efforts towards SARS-CoV 2 MPro inhibitor design generally neglect an allosteric mechanism linked to His41-Cys145 catalytic dyad disruption and thus do not target the open conformational state. Using both empirical and computational evidence, it was found that the rotation of the His41 imidazole side chain along the His41 backbone dihedral from 0.5 rads to -0.25 or -0.6 rads provides a conformational pathway for mediating MPro activity. In this work, the importance of enhanced sampling methods such as metadynamics when performing computer-aided MPro inhibitor design is demonstrated via the sampling of the dyad disruption pathway in a computationally feasible timescale. We calculate an MPro dyad-open against dyad-closed free energy difference of 3.55 ± 1.21kJ/mol, which is compensated by His41 imidazole-ligand interactions. The implications of this result for MPro inhibitor design are discussed
Hydrogen over helium: A philosophical position
Authors: Vernon Rene
Published: November 2022

Hydrogen is troublesome in any periodic table classification. This being so it may as well be placed in a position that confers desirable attributes to the arrangement of the elements, while notionally recognising its lineage to the group 1 alkali metals and the group 17 halogens. Since the noble gases bridge the halogens and the alkali metals, and hydrogen encompasses the transition from the alkali metals to the halogens, there is more to the idea of hydrogen over helium.
SELF-ASSESSMENT AS A PSYCHOLOGICAL AND PEDAGOGICAL CATEGORY: SCIENTIFIC VIEWS AND APPROACHES
Authors: Сафаралиева Разият Айнудиновна , Пряжникова Елена Юрьевна
Published: November 2022

Проведен аналитический обзор литературы, посвящённой изучению самооценки как психолого-педагогической категории и её особенностям у детей старшего дошкольного возраста, проявлениям индивидуальных особенностей отношения ребенка к самому себе. Установлено, что концепция самооценки широко используется в нескольких дисциплинах, однако кажется, что консенсус в отношении её концептуализации и операционализации ещё не достигнут. Отмечены индивидуальные различия самооценки и особенности её формирования у ребёнка старшего дошкольного возраста.

The article provides an analytical review of the literature devoted to the study of self-esteem as a psychological and pedagogical category and its characteristics in children of older preschool age, manifestations of individual characteristics of the child's attitude towards himself. The concept of self-assessment has been found to be widely used across several disciplines, however it seems that there is no consensus on its conceptualization and operationalization yet. Individual differences in self-esteem and features of its formation in a child of senior preschool age are noted.
TRAINING TO RUSSIAN AS A PEDAGOGICAL RESOURCE FOR FORMING THE THAI SCHOOLCHILDREN’ INTERCULTURAL COMMUNICATIVE COMPETENCE
Authors: Милюгина Елена Георгиевна , Праюнраттанавонг Кампол Ванналак
Published: November 2022

Актуальность проблемы формирования межкультурной коммуникативной компетенции тайских школьников обусловлена динамично развивающимся молодежным образовательным сотрудничеством России и Таиланда. В статье представлена педагогическая система опережающего обучения школьников русскому языку как иностранному с применением лингвокультурного подхода. С учетом особенностей обучения русскому языку в школах Таиланда, предложен комплекс мер по формированию межкультурной коммуникативной компетенции тайских школьников для обеспечения образовательного сотрудничества с российскими сверстниками.

In the context of Russia and Thailand dynamically developing youth cultural exchanges the formation of participants in these bilateral relations intercultural communicative competence is actualized. The authors consider that the pedagogical resource for the Thai schoolchildren’ intercultural communicative competence formation is training to Russian using linguocultural approach. The authors describe the features of training to Russian in Thailand educational institutions and propose a set of measures to enhance the Thai schoolchildren of intercultural communicative competence formation in training to Russian.
THE CONTENT OF THE STRUCTURAL COMPONENTS OF THE EXPERIENCE OF MORAL INTERACTION OF STUDENTS WITH OTHER PEOPLE
Authors: Разумовская Анна Александровна
Published: November 2022

В статье обосновывается роль нравственных отношений в гуманизации как общества в целом, так и отдельных сфер общественной жизни, в частности, профессиональной. Представляется взаимосвязь нравственных отношений и нравственного взаимодействия. Аргументируется, что подготовка студентов к нравственному взаимодействию с окружающими их людьми предполагает формирование у них опыта такого взаимодействия и предлагаются компоненты такого опыта. Раскрывается содержание компонентов опыта нравственного взаимодействия студентов с другими людьми. Обосновывается, что содержание когнитивного компонента опыта образует нравственное знание относительно нравственности, взаимодействия, нравственного взаимодействия, ценности; содержание мотивационно-ценностного компонента наполняется ценностями, определяющими мотивы нравственного взаимодействия студентов; содержание коммуникативного компонента образует диалогическая направленность личности в общении; содержание поведенческого компонента включает нравственные качества. Приводятся критерии отбора содержания компонентов опыта нравственного взаимодействия студентов с другими людьми.

The article substantiates the role of moral relations in the humanization of both society as a whole and individual spheres of public life, in particular professional. The relationship of moral relations and moral interaction is presented. It is argued that the preparation of students for moral interaction with the people around them involves the formation of their experience of such interaction and the components of such an experience are proposed. The content of the components of the experience of moral interaction of students with other people is revealed. It is substantiated that the content of the cognitive component of experience forms moral knowledge regarding morality, interaction, moral interaction, value; the content of the motivational-value component is filled with values that determine the motives for the moral interaction of students; the content of the communicative component forms the dialogic orientation of the personality in communication; the content of the behavioral component includes moral qualities. Criteria are given for selecting the content of the components of the experience of students' moral interaction with other people.
ON THE PROBLEM OF SELECTING COMPLEX STRUCTURES OF SCIENTIFIC STYLE OF SPEECH
Authors: Цховребов Алан Солтанович
Published: November 2022

Приведен анализ сложных структур научного стиля речи: методом сплошной выборки проанализированы учебники профессионального цикла, по которым осуществляется процесс обучения иностранных студентов будущей специальности в инженерно-техническом вузе. В работе отобраны сложные структуры с сочинительной связью, в употреблении которых испытывают потребность иностранцы-нефилологи в учебно-профессиональной сфере, поскольку сведений о сложном предложении, полученных на подготовительном курсе, недостаточно для понимания и воспроизведения специфических моделей синтаксиса научного стиля речи. В ходе исследования установлен круг сложных предложений, которым необходимо обучать иностранцев на продвинутом этапе. Проведенный анализ сложных структур, выделенных в текстах дисциплин профессионального цикла, позволит разработать методическую стратегию обучения данным сложным синтаксических моделям иностранцев-нефилологов инженерно-технического профиля на продвинутом этапе (В2).

The article provides an analysis of the complex structures of the scientific style of speech, namely, the textbooks of the professional cycle are analyzed by the continuous sampling method, according to which the process of teaching foreign students of the future specialty in an engineering and technical university is carried out. The paper selects complex structures with a compositional connection, the use of which is needed by non-philologists in the educational and professional field, since the information about a complex sentence received during the preparatory course is not enough to understand and reproduce specific models of the syntax of scientific style of speech. In the course of the study, a range of complex proposals has been identified that need to be taught to foreigners at an advanced stage. The analysis of complex structures highlighted in the texts of the disciplines of the professional cycle will allow us to develop a methodological strategy for teaching these complex syntactic models to foreigners-non-philologists of engineering and technical profile at an advanced stage (B2).
Hand function rehabilitation after Brachial artery revascularization surgery at elbow due to dog bite: A case report
Authors: Rose Sumi , N Kaviya , A Shruti K
Published: November 2022

Dog bite injuries to the upper extremity can result in traumatic neurovascular and musculotendinous damage. The brachial artery is the most frequently injured artery in the upper extremity. The study was undertaken with an intention to rehabilitate the hand function post brachial artery revascularization surgery at elbow caused by dog bite. A single case experimental study data was collected with hand dynamometer for the grip strength pinch grip and movement analysis was done using range of motion ROM and manual muscle testing MMT for muscle power. 3 months of physical therapy intervention was done using hand exerciser unit and galvanic stimulation. Result showed significant hand function strength improvement. Wrist extension was 47 and radial deviation 45 and ROM of wrist showed overall 60 improvement post treatment session. Grip strength showed minimal improvement of 7.5 whereas pinch grip had 33 improvement. There was marked improvement in ROM and strength post intervention although the hand function grip strength and pinch grip did not show marked improvement.
Treatment of Hepatitis C virus infection
Authors: S Shankar P
Published: November 2022

None
Evaluation of Plasma Total Antioxidant Capacity Levels and Osteocalcin in Prediabetes and Healthy Subjects
Authors: S Atre Akshay , Delphine Silvia C R Wilma , V C Suresh , M R Nagaraja , H S Madhuvan
Published: November 2022

Prediabetes can also be termed as intermediate or borderline hyperglycaemia. These individuals were defined as having impaired fasting glucose IFG. Prediabetes is associated with oxidative stress predisposing the patients to an increased risk of cardiovascular disorders. Osteocalcin OCN is a protein that is secreted in large amounts in the bone extracellular matrix. OCN regulates Beta cell proliferation insulin gene expression and secretion suggesting a potential role in glucose metabolism and in the pathogenesis of glucose alterations in Type2 Diabetes mellitus T2DM physiopathology. Oxidative stress has an inhibitory role on osteoblast. Hence this study was carried out with a total of 80 male subjects within age group of 30-70 years containing 40 controls and 40 cases. Total antioxidant capacity TAC and OCN were evaluated in prediabetic and healthy subjects and were correlated among the study groups. This may lay a step mainly in early diagnosis of diabetes and prevent its complications.
Oral submucous fibrosis; Journey towards Malignancy
Authors: Gupta Sonia , Kaur Jawanda Manveen
Published: November 2022

Smoking chewing of tobacco and areca nut consumption of alcohol has become common social habits in entire world leading to many oral disorders approaching towards cancer. Oral submucous fibrosis OSMF is one of the commonest precancerous conditions of oral mucosa caused mainly by the habit of areca nut chewing leading to generalized fibrosis of oral mucosa that further results in marked rigidity and inability to open the mouth. Worldwide 2.5 million people are affected with OSMF with most cases concentrated on the Indian subcontinent especially southern India. The disease is characterized by atrophied epithelium and juxta epithelial hyalinization followed by fibrosis in the underlying lamina propria of oral mucosa. OSMF has become of great concern to a general practitioner as well as a dentist because of its premalignant nature and resemblance to some dermatological disorders like scleroderma. It is very essential to diagnose this disease at an early stage to prevent further adverse effects on oral health.
Congenital Mucocele of the Tongue in a Neonate
Authors: Hasim Abdul Aziz Abu , G Devani Ravindra , D Shinde* Nandkishor , Abdul Baseer Mohammed
Published: November 2022

Mucoceles are benign lesions of the oral cavity that develop as a result of retention or extravasation of mucous material from minor salivary glands. Congenital mucoceles are very rare. Mucocele involving the ventral surface of the tongue in neonates is further rare with sporadic cases reported in the world literature accounting to 2-8 of oral mucoceles. This report describes a 5-day male neonate with large congenital mucocele involving the ventral surface of the tongue with associated difficulty in breast feeding. An en block excision of the cystic swelling with removal of entire cyst wall was done.
A Clinical Study on the Gynaecological Parameters Pertaining to Polycystic Ovarian Syndrome (PCOS)
Authors: R* Showri , T Rajini
Published: November 2022

Background and Aim Polycystic ovarian syndrome PCOS has a major influence on women of reproductive age group resulting in extreme stress at times crippling in nature. This study aimed at evaluating and correlating early signs of PCOS to prevent the future implications.Methods This observational cross-sectional study was conducted between September 2018 and March 2020. Ninety subjects with PCOS based on Rotterdamrsquos criteria were recruited. Details on menstrual history anthropometric measurements infertility spontaneous abortions and acanthosis nigricans were noted and assessed. Excel and Statistical Analysis System SAS version 9.4 software have been used for the analysis. Comparison between two groups and inferential data was evaluated using p-value and 95 CI with Chi-square test.Results The mean age of menarche was 12.97 plusmn 1.17 years. Oligomenorrhea secondary amenorrhea and regular menstrual cycle were observed in 51 56.6 14 15.5 and 25 27.7 subjects respectively. Anthropometric measures of body mass index BMI ge 25 kgm2 waist circumference WC ge 88 cm and hip and waist ndash hip ratio WHR ge 0.85 were observed in 55 61.1 67 74.4 and 86 96.6 subjects respectively. Infertility was observed in 53 58.8 and spontaneous abortions in 24 26.6 subjects. Acanthosis nigricans an indicator of insulin resistance was seen in 61 67.7 subjects which positively correlated with increased BMI and WC.Conclusion Correlation of anthropometric details with insulin resistance infertility and spontaneous abortions can go a long way in preventing the same based on which the pregnancy should be treated as high risk to prevent pregnancy loss and metabolic derangements.
Respiratory Syndromes
Authors: P S Shankar
Published: November 2022

The disease presents with clinical manifestation that exhibit in the form of symptoms and signs. A syndrome is a set of signs and symptoms which are characteristically associated with a disease or disorder. Some of the syndromes have been named after the people who discovered them first eponymous. In recent years the diseases are named descriptively based on the symptoms or underlying causes instead of the discoverer. The present study attempts to collect different syndromes associated with respiratory diseases. Many syndromes are associated with manifestations related to different systems in addition to the features of respiratory disorders.
Sticky Information Versus Sticky Prices Revisited: A Bayesian VAR-GMM Approach
Authors: Kurozumi Takushi , Oishi Ryohei , Van Zandweghe Willem
Published: November 2022

Several Phillips curves based on sticky information and sticky prices are estimated and compared using Bayesian VAR-GMM. This method derives expectations in each Phillips curve from a VAR and estimates the Phillips curve parameters and the VAR coefficients simultaneously. Quasi-marginal likelihood-based model comparison selects a dual stickiness Phillips curve in which, each period, some prices remain unchanged, consistent with micro evidence. Moreover, sticky information is a more plausible source of inflation inertia in the Phillips curve than other sources proposed in previous studies. Sticky information, sticky prices, and unchanged prices in each period are all needed to better describe inflation dynamics.
Expedition of the Institute of Geography named after V.B. Sochava SB RAS and the Portulan Club to the Eastern Sayan Mountains (Munku-Sardyk mountain range) in April-May 2021
Authors:   Institute of geography to them. V.B. Sochavy, SB RAS, Kitov A.D. , Kovalenko S.N. ,   Irkutsk State University, Ivanov E.N. ,   Institute of geography to them. V.B. Sochavy, SB RAS, Denisenko I.A. ,   Institute of the Earth's Crust SB RAS
Published: November 2022

The results of the spring expedition of the Student and Teaching Club "Portulan" held in 2021 together with the staff of the Institute of Geography of the Siberian Branch of the Russian Academy of Sciences and the Institute of the Earth's Crust of the Siberian Branch of the Russian Acad- emy of Sciences to the area of Mount Munku-Sardyk are summed up, within the framework of which field scientific studies of nival-glacial formations, landscape-forming processes, slope forms of the relief of the territory of the basins of the White Irkut and Muguvek rivers were carried out. Traditionally, the weather, the state of the Peretolchina glacier (northern), high-altitude ice and the Active mountain stream were monitored, according to which detailed georadar profiling was carried out