bluuebunny/crossref_metadata_2025 huggingface dataset:
Current and Future Pharmacopoeial Requirements for the Quality of Extemporaneous Medicinal Products: A Review of Regulatory Standards
Authors: Shishova L. I. , Yarutkin A. V. , Bagirova V. L.
Published: September 2024

INTRODUCTION. The organisation of extemporaneous compounding in pharmacies is currently considered to be a priority for the national healthcare system. Extemporaneous medicinal products used by patients should meet high quality, safety, and efficacy standards. Provision of consistent and science-based requirements for the quality of medicines, particularly those compounded in pharmacies, is a key area of concern for standardisation.

AIM. This study aimed to analyse international experience and determine areas for the improvement of standardisation approaches of the State Pharmacopoeia of the Russian Federation to the quality of medicinal products compounded in pharmacies.

DISCUSSION. The study investigated the common and distinctive properties of extemporaneous preparations compounded in pharmacies (and not subject to registration) and medicinal products manufactured by pharmaceutical companies. The authors analysed the requirements and recommendations for compounding and quality assurance of extemporaneous medicinal products provided by the regulatory and pharmacopoeial authorities of the Russian Federation, the Republic of Belarus, the European Union, the United Kingdom, the USA, and Canada. The United States Pharmacopeia includes circa 150 individual monographs for non-sterile compounded drug products with particular compositions and over 20 individual monographs for sterile compounded drug products. The European Pharmacopoeia requires that extemporaneous preparation should be organised within the quality assurance framework of a pharmacy after a proper risk assessment. In the Republic of Belarus, extemporaneous medicinal products are compounded in line with the requirements of the Good Compounding Practices and the State Pharmacopoeia of the Republic of Belarus, which provide rapid testing procedures for extemporaneous medicinal products.

CONCLUSIONS. The study identified the following areas for the development of requirements for the quality of medicinal products compounded in pharmacies: the determination of rapid testing approaches; the development of pharmacopoeial monographs for active pharmaceutical substances used in extemporaneous compounding, with the Identification section supplemented with an additional subsection on pharmacy-specific analytical procedures; and the development of pharmacopoeial monographs for frequently used compounding formulae.
Planning a Clinical Development Programme for Medicinal Products for Irritable Bowel Syndrome: An Analysis of the European Medicines Agency’s Recommendations
Authors: Gerasimets E. A. , Rumyantsev N. A. , Ilin R. S. , Goryachev D. V.
Published: September 2024

INTRODUCTION. Irritable bowel syndrome (IBS) is a chronic functional disorder present in over 13% of the population. Despite the wide prevalence of IBS, there is currently a lack of well characterised authorised medicinal products to treat IBS. This situation stems from both poor engagement in the development of such medicinal products and the absence of sound approaches to their regulatory review. The intensification of drug development aimed at improving the safety and efficacy of IBS therapy in the context of the growing common pharmaceutical market of the Eurasian Economic Union (EAEU) requires guidelines for planning and conducting clinical trials of medicinal products for IBS.

AIM. This study aimed to evaluate the possibility of using the methodological approaches described in international guidelines for the development of national recommendations for conducting clinical trials of medicinal products for IBS.

DISCUSSION. The authors analysed the main provisions of the Guideline on the evaluation of medicinal products for the treatment of IBS by the European Medicines Agency (EMA). The analysis identified the methodological tools, the scope and stages of clinical trials, and the efficacy criteria for each study stage. The authors assessed the specific aspects of diagnosing IBS, which are considered when determining the effectiveness of therapeutic interventions. This review highlighted the need for the harmonisation of national and international methodological approaches to the evaluation of clinical trial results that would ensure more robust results of clinical trial reviews conducted in different countries. The authors determined the considerations for planning exploratory and confirmatory clinical trials, including the selection of endpoints, design, and duration of clinical trials in adults and children, as well as the sex distribution of the trial population.

CONCLUSIONS. The EMA’s recommendations may guide the planning of clinical programmes for novel medicinal products for IBS. These recommendations may be applied by experts reviewing clinical trial results, as well as developers creating new medicinal products.
Caracterização dos profissionais de saúde que atuavam em Unidades de Terapia Intensiva (UTIs) COVID: crenças, medos e percepções
Authors: Zambonato Daiana , Fachinetto Juliana Maria , Bernat Kolankiewicz Adriane Cristina , Uhdich Kleibert Karine Raquel , Schalanski Krause Lenara , Abreu Anna Paula , Weber Fell Ana Paula , Gonzales da Silva José Antônio , Colet Christiane
Published: September 2024

A pandemia causada pelo novo coronavírus afetou diretamente a saúde mundial. Nesse cenário de enfrentamento da COVID-19, mudanças significativas foram vivenciadas na realidade do trabalho, em especial dos profissionais de saúde atuantes em Unidades de Terapia Intensiva (UTIs) COVID. OBJETIVO: analisar o perfil sociodemográfico e de saúde de profissionais de saúde atuantes em UTIs COVID e suas percepções acerca da pandemia. METODOLOGIA: trata-se de um estudo transversal, analítico, quantitativo e multicêntrico, que foi realizado com profissionais de saúde que atuam nas UTIs COVID da região Missioneira do Rio Grande do Sul. Foi utilizado como instrumento de coleta de dados o questionário sociodemográfico, laboral e clínico, elaborado pelas pesquisadoras e foi realizado análise descritiva dos dados. RESULTADOS: participaram do estudo 205 profissionais de saúde. Desses, 76,6% são do sexo feminino. A faixa etária predominante está entre os 18 a 30 anos (46,3%). Em relação ao estado civil, 105 (51,2%) declararam ter companheiros e, 52,7% têm filhos. CONCLUSÃO: a Enfermagem representa maior percentual de trabalhadores nas Unidades estudadas e, embora atue a pouco tempo na profissão, possuem especialização na área de atuação. Apesar da alta vigilância, do medo de contrair a doença e dos cuidados preventivos, muitos profissionais foram infectados pela COVID-19.
Hasta Değerlendirmeleri: Halkla İlişkiler Perspektifinden Nitel Bir Analiz
Authors: Demir Hüseyin , Akar Tuncay , Doğan Ayşegül
Published: September 2024

Amaç: Çalışmanın amacı özel bir sağlık hizmeti sunucusuna başvuran hastalar tarafından hizmet sunum sürecine ilişkin yapılan değerlendirmeleri halkla ilişkiler perspektifinden incelemek ve hasta beklentilerini araştırmaktır.
Yöntem: Çalışmada betimsel araştırma yaklaşımı kullanılarak 81 hasta değerlendirmesi nitel veri analizine tabi tutulmuştur. Veri analizinde MAXQDA 2022 yazılımı kullanılmıştır. Veri analiz sürecinde doküman incelemesi yaklaşımı kullanılarak veri ilk aşamada kodlama işlemine tabi tutulmuş sonrasında ise elde edilen kodlar birleştirilerek temalar elde edilmiştir.
Bulgular: Hasta değerlendirmelerinin analizi sonucunda 4 tema ve 19 kod belirlenmiştir. Hatalı uygulamalar (işlem, iletişim, gereksiz işlem ve sistem hataları), personel tutum ve davranışları (ilgisizlik, sert davranışlar, hassasiyet göstermeme, işlem sırasında gereksiz davranışlar ve personelin olumsuz konuşma tarzı), tedavi sonuçları (sonucu beğenmeme, kurumu tercih etmeme, tedaviden vazgeçme, güvensizlik, pişman olma ve olumsuz tavsiye) ve tedavi maliyetleri (gereksiz ödemeler, yüksek fiyatlar, fiyat-performans dengesizliği ve ticarethane hissi vermesi) ile ilgili değerlendirmeler belirlenen temalardır. Hasta değerlendirmelerine ilişkin bulgular, hastaların sağlık hizmeti deneyimine ilişkin olumsuz bir tutum geliştirdiğini ve beklentilerinin karşılanmadığını göstermiştir. Bu durum bir yandan hasta açısından karşılanması gereken beklentileri ortaya koyarken diğer yandan ise sağlık hizmeti sunucusu açısından iyileştirmeye açık yönleri ortaya koymuştur.
Sonuç: Genel olarak değerlendirildiğinde, ağız ve diş sağlığı alanında işletmecilik perspektifinden hizmet sunum sürecinin yürütülmesi yaklaşımının güçlendirilmesine ihtiyaç duyulduğu söylenebilir. Çalışma bulgularının başta ağız ve diş sağlığı hizmeti sunucuları olmak üzere sağlık hizmeti alanında karar vericiler açısından faydalı olacağı düşünülmektedir.
Gebelerde Cinsel Sağlık Okuryazarlığının Cinsellik Tutumları ile İlişkisi
Authors: Öztürk Altınayak Serap , Özkan Hava
Published: September 2024

Amaç: Bu araştırma ile gebelerde cinsel sağlık okuryazarlığının cinsellik tutumları ile ilişkisinin araştırılması amaçlanmaktadır.
Yöntem: Bu araştırma, kesitsel ve ilişki arayıcı tasarımda yapılmıştır. Araştırma Karadeniz Bölgesinde bir hastanenin Kadın Hastalıkları ve Doğum kliniğine başvuran 404 gebe ile yürütülmüştür. Veriler; Sosyodemografik Bilgi Formu, Cinsel Sağlık Okuryazarlık Ölçeği ve Gebelikte Cinselliğe Karşı Tutum Ölçeği ile toplanmıştır. Verilerin analizinde; sayı, yüzde, minimum ve maksimum değerler, ortalama standart sapma, bağımsız gruplarda t testi, Varyans Analizi, Tukey HSD, Tamhane’s, Pearson korelasyon analizi ve basit doğrusal regresyon analizi yapılmıştır.
Bulgular: Gebelerin yaş ortalaması 28,775,80, eşlerinin yaş ortalaması 32,446,01, gebelik haftasının 34,863,45 olduğu bulunmuştur. Gebelerin Cinsel Sağlık Okuryazarlık Ölçeğinden aldıkları toplam puan ortalaması 50,668,41, Gebelikte Cinselliğe Karşı Tutum Ölçeğinden aldıkları toplam puan ortalaması ise 115,9217,09 olduğu belirlenmiştir. Cinsel Sağlık Okuryazarlık Ölçeği ile Gebelikte Cinselliğe Karşı Tutum Ölçeği toplam puan ortalamaları arasında istatiksel olarak anlamlı ve pozitif yönde orta düzeyde bir ilişki olduğu saptanmıştır (p
Yaşlı Bireylerde Aromaterapi Kullanımı
Authors: Duman İbrahim , Ceyhan Özlem , Taşcı Sultan
Published: September 2024

Günümüzde demografik değişimlerin etkisiyle dünya genelinde yaşlı nüfus artmaktadır. Yaşın artmasıyla beraber yaşlı bireylerde artan kronik hastalıklar ve geriatrik sorunlar, yaşam kalitesini düşürmekte ve sağlık harcamalarını artırmaktadır. Kronik hastalıkların yanı sıra, geriatrik sorunların erken tespiti ve yönetimi önem arz etmektedir. Son yıllarda yaşlı bireylerin sağlık sorunlarının yönetiminde tamamlayıcı ve integratif tedavi yöntemleri daha çok tercih edilmektedir. Tamamlayıcı ve integratif tedavi uygulamaları arasında yer alan aromaterapi, esansiyel yağların kullanımıyla fiziksel ve psikolojik iyilik hali sağlamada etkili bir yöntemdir. Aromaterapi, ağrı, anksiyete, depresyon, uyku bozuklukları ve diğer geriatrik sorunların yönetiminde umut verici sonuçlar ortaya koymaktadır. Araştırmalar, aromaterapinin yaşlı bireylerin sağlık durumunu iyileştirmede olumlu etkiler sağladığını ve yaşam kalitesini artırdığını göstermektedir. Aromaterapinin kullanımının yaygınlaştırılması, yaşlı bireylerin sağlık sorunlarının yönetiminde farmakolojik olmayan yöntemlerin önemini vurgulamaktadır. Aromaterapinin etkili olabilmesi için uzman rehberliğinde ve kişiye özgü uygulanması önemlidir. Bu derlemede, aromaterapinin yaşlı bireylerdeki terapötik etkileri son yıllarda yapılan bilimsel araştırmalar incelenerek sunulmuştur.
Innovative food products with saturated fats substitutes
Authors:   Saratov State Vavilov Agrarian University, Nepovinnykh N.V.
Published: September 2024

Purpose. Development of plant oil-based bigels using sodium alginate hydrogel and beeswax-based oleogel, selection of the optimal ratio between the concentration of hydrogel and oleogel in the composition of bigel, study of its thermal and textural characteristics. Materials and Мethods. Effect of hydrogel-to-oleogel ratio on bigel production was evaluated in terms of thermal and structural-mechanical properties. The following recipe ingredients: drinking water, sodium alginate, beeswax, grape seed oil, were used to produce bigels. Results. It was found that increasing proportion of hydrogel had influenced on thermal properties, strength and adhesiveness of the bigels. In general, an increase hydrogel fraction made it possible to obtain bigels with stronger mechanical properties and higher heat resistance, which is important to consider when creating technologies for innovative food products. Conclusion. For developing various food products with substitution of saturated fats with food bi-gel matrices, it is necessary to regulate competently their physicochemical and textural properties.
Leveraging Artificial Intelligence to Linguistically Analyze 13 Translations of the Level of Personality Functioning Scale – Brief Form 2.0 & Personality Disorder Severity ICD-11 Scale: A Methodological Introduction & Proof-of-Concept Study
Authors: Natoli Adam P.
Published: September 2024

Translation of psychological measures into multiple languages increases their accessibility for researchers and clinicians working with linguistically diverse populations. However, the validity and utility of translated instruments depends on the quality of their translation, and differences across translations in key linguistic characteristics, such as sentiment and emotional tone/intensity, could introduce unintended but systematic measurement bias. This proof-of-concept study introduces and demonstrates the use of natural language processing (NLP), a subfield of artificial intelligence, to linguistically analyze 13 translations of two personality measures that have been previously translated into numerous languages. NLP was used to generate estimates reflecting specific linguistic characteristics of test items (i.e., emotional tone/intensity, sentiment, valence, arousal, and dominance), which were then compared across translations at both the test- and item-level, as well as between the two instruments. Following a discussion of results, I summarize the current limitations of this approach and propose strategies for advancing this methodology.
Towards a Latent Space Cartography of Subjective Experience in Mental Health
Authors: Manuel Shawn , Gagnon Jean , Gosselin Frédéric , Taschereau-Dumouchel Vincent
Published: September 2024

The way that individuals subjectively experience the world greatly influences their own mental well-being. However, it remains a considerable challenge to precisely characterize the breadth and depth of such experiences. One persistent problem is the lack of objective tools for directly quantifying and comparing narrative reports of subjective experiences. Here, we develop a new approach to map and compare reports of experience using the latent space of artificial neural networks (ANNs). Using a series of 31 prompts, including 30 images and 1 open-ended question, we quantified how the verbal reports provided by participants (n=210, 50% female) deviate from one another and how these variations are linked to subjective experience and mental health. We found that latent space embeddings of experience can accurately predict subjective judgments of valence and arousal in a series of emotional pictures. Furthermore, we show that narrative reports to ambiguous images can accurately predict transdiagnostic factors of mental health. While distortions in the latent space of ANNs are notoriously difficult to interpret, we propose a new approach to synthesize visual stimuli with generative artificial intelligence that can be used to explore semantic distortions in reported experiences. In sum, latent space cartography could offer a promising avenue for objectively quantifying distortions of subjective experience in mental health and could ultimately help identify new therapeutic targets for clinical interventions.
Influencer Marketing Unveiled: Navigating the Dynamics of Social Media Impact, and a Comprehensive Bibliometric Analysis
Authors: Bhandari Gyani
Published: September 2024

This article explores the intricate landscape of influencer marketing within the realm of social media, with a specific focus on the evolving role of influencers, and their significant impact on consumer behavior. The study employs a rigorous bibliometric analysis, utilizing the Dimensions Digital Science database, to uncover key research trends, influential works, and collaborative networks in the influencer marketing domain. The methodology ensures transparency and reproducibility in data collection, leading to a carefully curated dataset. The literature review sheds light on the complexities of influencer-brand collaborations, emphasizing the need for authenticity. Through real-world examples, the article highlights the potential pitfalls in influencer marketing and the importance of congruence between influencers and brands for successful outcomes. The findings contribute to a collective understanding of influencer marketing, providing valuable insights for marketers, scholars, and industry professionals.
Cooperative Investment in Gandaki Province
Authors: Lohani Lila Raj
Published: September 2024

Cooperatives can truly transform the economy of a country to a level of prosperity. In this regard, this study aimed to explore the possible overall aspects of cooperatives in the Gandaki Province. It is based on the data provided by the Cooperative Registrar Office, Kaski, and the data published by the Department of Cooperative (2022). The present study used integrated research designs for overall discussion. The investment deficiency syndrome of the nation as well as the province could be healed through the better management of the cooperative’s fund and can achieve the goal of “Prosperous Nepal; Happy Nepali”, the slogan of the fifteenth plan. This study found that the cooperative movement is well practiced in the Gandaki province but the regulation and control of the cooperatives sector is very weak. If the proper database is maintained and thoroughly monitored, the aim of the cooperative movement can be achieved in a shorter period. It would wipe out the major unemployment problem of the country boost the national economy, and correct the unfavorable Balance of Trade. This study recommends the investment of cooperative funds in the productive sector rather than in the unproductive one. Moreover, cooperatives must be concerned to uplift the status of marginalized, deprived, women and weak sections of the society which assures the sustainable development of the society and the nation. Additionally, cooperatives must support and attract young people to the agricultural and cottage sector, and Small and Medium Enterprises.
Performance evaluation of Uruguayan dairy farming systems
Authors: Pedemonte Ana , García Suárez Federico , Artagaveytia Jorge , Giudice Gabriel , Chilibroste Pablo
Published: September 2024

In the last 20 years, the Uruguayan dairy sector has intensified and concentrated on higher cow productivity, maintaining the herd, smaller land, and fewer farms. The research aims are to identify, describe, and evaluate the economic performance of different types of dairy farms. A sample of 284 farms from the National Dairy Farm Survey 2019 was used (representing 2,021 dairies); using k-means Cluster analysis with the variables: cow productivity, stocking rate, land productivity, concentrate, roughage, and grass intake (per hectare). We identified six farm types, three with high participation of grass in the cows’ diets (HG, 60% or more of dry matter intake), and the other three focused on supplementation (HS); with three intensification levels (1-low, 2-intermediate and 3-high productivity per ha). For the 2018/19 season three types of farms presented the best economic performance (HS-3, HG-3, and HG-2), including those with the highest stocking rate and grass intake per hectare, and more than USD 225 Economic Farm Surplus (EFS) per hectare with the lower unitary cost. Other two types exhibited intermediate economic performance (HS-2 and HG-1) with EFS close to zero and unitary cost similar to price. And one type (HS-1) displayed the worst economic performance, with negative indicators and the largest number of farms with very low productivity.
Farm dairy effluent application
Authors: Illarze Gabriela , Irisarri Pilar , Del Pino Machado Amabelia
Published: September 2024

Dairy intensification produces a large amount of farm dairy effluents (FDE). The final disposal of FDE is generally to the soil as fertilizer. While this use of FDE as fertilizer has numerous benefits, such as reducing the application of synthetic fertilizers or improving soil quality, there are concerns about the environmental and health risks associated with microbial pathogens from animal waste, the spread of antibiotic resistance genes, nutrient losses and greenhouse gases (GHG) emissions. Furthermore, how this agricultural practice impacts the composition and functionality of soil microbial communities has not yet been elucidated. This thesis aimed to evaluate the impact of FDE applications on soil GHG emissions, the composition, activity and diversity of its microbial community, and health risks. The FDE were collected raw and from a two-stage stabilization lagoon. The N application rate normalized to 200 kg N ha−1 was divided into four seasonal applications compared to urea fertilization or a no-aggregate control. Soil samples were taken after each application for microbial and physicochemical characterization and GHG fluxes were measured up to twenty days after each application. The pasture was harvested according to typical grazing management. Repeated application of both types of FDE increased the soil nutrient status and enhanced microbial activity. Higher fescue pasture production and macronutrient content with FDE than the control positioned FDE application to soil as an alternative disposal. However, N2O emissions increased after applying both FDE’s, most notably with raw FDE. Soil microbial community composition was not significantly influenced by FDE applications, but functional diversity shifted with raw FDE. Lagoon storage effectively reduced organic C and total N along with pathogenic indicator bacteria and changed the bacterial community composition except in winter. Beta-lactam resistance genes were detected in both FDEs, but not in the soil after repeated applications.
Prosedur Administrasi Pengangkutan Limbah Bahan Berbahaya dan Beracun Pada PT XX Jakarta
Authors: Karomah Nurul Giswi , Amalia Fadwa
Published: September 2024

This research was conducted to find out how the administrative procedures for transporting B3 waste at PT Global Mandiri Marine, the purpose of this study was to find out the description of the procedures and constraints and alternative solutions in solving the problem. This research method is descriptive qualitative with data collection techniques through literature, interviews and observation, namely direct observation of the object under study. The obstacles that occurred in the Administration Procedure for the Transport of B3 Waste at PT Global Mandiri Marine, there were errors in inputting the weight and type of waste, errors in providing documents, and leaks of B3 waste. The solutions implemented are still not effective because several alternatives sometimes still use estimates of the weight and type of B3 waste, raising awareness among parties regarding the correct administration of B3 waste transportation in accordance with applicable regulations is to calculate the weight of the waste directly using a scale. and the provision of festronic data or manifests is given truthfully, and uses good quality for B3 waste packaging, so that the transportation of B3 waste can run properly and according to company procedures.
The Moderating and Mediating Roles of Self-Esteem and Susceptibility to Normative Influence in the Relationship Between Brand Love and Brand Loyalty
Authors: U.A.S. Gunawardana , M.A.A. Malkanthie
Published: September 2024

Purpose: The objective of this investigation is to evaluate the role of Self-Esteem (SE) and Susceptibility to Normative Influence (SNI) in the relationship between brand love and brand loyalty within the Fast-Moving Consumer Goods (FMCG) industry in Sri Lanka. Specifically, this study aims to determine whether SE and SNI act as moderators or mediators in this relationship. Since there is an unambiguously identified gap in the literature, there still exists insufficient agreement and acceptance in the existing literature about the correct role of Self-esteem and SNI in the relationship between brand love and brand loyalty, and previous researchers' findings are contradictory. Examining the relationship between brand love and brand loyalty across cultures and industries is another well-stated necessity.
Design/methodology/approach: This investigation used a quantitative methodology and thus, a self-administered survey was distributed to the 390 participants in the sample who are consuming FMCG products in Sri Lanka. The sample was selected using a purposive sampling technique. Regression analysis was carried out to test the hypothesized relationship between dependent, independent, mediating, and moderating variables.
Findings: Researchers concluded that in the FMCG sector of Sri Lanka, SE and SNI do not exert significant moderation on the relationship between brand love and brand loyalty. However, it was observed that SE and SNI do play a partial mediating role in this relationship.
Originality: Despite a clearly identified gap in the literature, there remains insufficient consensus regarding the role of SE and SNI in the relationship between brand love and brand loyalty. Existing studies present contradictory findings, highlighting the need for further investigation to clarify these roles. This research is the first to clarify whether SE and SNI function as moderators or mediators in the relationship between Brand Love and Brand Loyalty, with a specific focus on the Fast-Moving Consumer Goods industry in Sri Lanka. It makes a substantial and original contribution to the existing body of knowledge.
Implications: This research addresses a gap in empirical knowledge by clarifying the precise roles of SE and SNI as evidenced by the findings. Additionally, the study contributes to the literature by examining the brand love-loyalty relationship in the Asian context and the FMCG industry, offering a more generalized theoretical conclusion applicable worldwide. The findings support the Brand Resonance Model's emotional path, particularly in Sri Lanka's FMCG industry.
Impact of Online Video Advertisement on Impulsive Buying Tendency with the Mediating Effect of Attitudes (Evidence from University Students in Sri Lanka)
Authors: H.B.N. Madhushanka , G.P.K. Nishadi
Published: September 2024

Purpose: TikTok is a growing video-sharing application that allows users to make and share short videos on any topic. At present, young consumer’s impulsive decisions have been increased steadily, due to higher exposure to TikTok on online context. Thus, this research was carried out to examine the factors impacting on impulsive buying tendency of young consumers with a particular focus on attitudes toward online advertisements.
Design/methodology/approach: Through a comprehensive survey conducted among 200 undergraduates at University of Ruhuna, data was collected based on a convenient sampling technique. Further, the collected data was analyzed using Smart PLS 4 software.
Findings: The findings indicated that informativeness, personalization, and credibility of online video advertisements positively affect attitudes toward online video ads. Additionally, the mediating effect was proved revealing that young consumers make impulsive purchasing decisions based on the attitude formation through informativeness, personalization, and credibility.
Originality: Although, the application of Tik Tok is important as a marketing tool, research on the TikTok platform is still scarce and inadequately documented.
Implications: The study provides practical advice for marketers and brand managers to focus on improving consumers’ perceptions through the video ad’s informativeness, entertainment, personalization, and credibility to encourage consumers to purchase impulsively.
OPTIMIZATION OF CROSS-PLATFORM APPLICATIONS USING THE REACT LIBRARY
Authors: Kutsenko Olexandr  , Bezverhiy Olexandr
Published: September 2024

In today's world, with the growing use of mobile devices, the importance of creating cross-platform applications that provide high performance and quality of user experience has increased significantly. Improving the creation of such applications using React and React Native opens up wide opportunities for developers due to the possibility of code reuse, high development speed and ease of innovation, and is especially relevant because it concerns not only the technological aspects of development, but also economic efficiency, quality of user experience and the speed of introducing innovations to the software market. Open source and active community communication allow rapid identification and resolution of issues, development of new features and enhancements, and the sharing of knowledge and experience between developers. This creates a positive environment for innovation and growth, promotes rapid technological progress, and improves the quality of end products. The paper analyzes the key aspects and challenges associated with the creation of cross-platform applications, analyzes the main types of optimizations at different levels of development, including the component level, the state and data level, the level of working with APIs and external data, as well as the loading and code level. Special attention is paid to the integration of synchronous and asynchronous rendering to achieve optimal performance and user experience. Highlights the benefits of flexible state management using state managers, as well as the importance of image and media optimization to improve overall website performance. The article notes the role of the developer community in the process of improvement and innovation. Developers who master these technologies and optimize their application can create products that not only meet the requirements of the time, but also form new standards in the field of mobile and web development. Further research and integration of the latest technologies into the development process of cross-platform applications will have a significant impact on the software industry.
Urolitíase em cão da raça Pug
Authors: Mazzonetto Pinto Raquel da Mata
Published: September 2024

The objective of this paper was to present a case of urolithiasis in a two-year old Pug weighing ten kilos, with a history of food allergy/atopic dermatitis. Upon physical examination, the animal presented mild abdominal pain upon palpation. The tutor indicated emesis 2 days ago. Upon ultrasound examination, it was possible to identify the presence of a 2.2 cm urolith in the bladder, in addition to cystitis in the urinary tract. The animal underwent surgical treatment, with cystotomy being the most suitable for this type of case. From the case report, it was found that racial or even familial predisposition was the main cause of urolith formation. In addition, the chances of urolithiasis occurring are greater in small breed dogs.
Long-Term Evaluation of Allopurinol Effectiveness in the Thai Population: Insights from 10 Years of Real-World Big Data Analysis
Authors: Jaruthamsophon Kanoot , Vichitkunakorn Polathep , Ruanglertboon Warit
Published: September 2024

Objective: This study aimed to evaluate the effectiveness and safety profile of allopurinol in Songklanagarind hospital, Thailand. Material and Methods: Electronic medical records (EMRs) of patients having undergone allopurinol treatment for gouty arthritis, or other pertinent indications, were retrospectively reviewed. The primary outcome of this study was the longitudinal measurement of uric acid levels. A linear mixed model (LMM) analysis assessed the statistical significance of uric acid reduction across hospital visits. The safety profile regarding allopurinol-related adverse drug reactions was assessed.Results: A total of 11,277 EMRs were extracted, of which 8,801 EMRs were eligible for further analyses. These records pertain to a cohort of 3,219 unique patients whose visits were arranged chronologically from the earliest to the fifth recorded visit. Overall, uric acid level decreased after allopurinol treatment in all patients. Across subsequent visits, the analysis, using LMM, found a significant reduction in uric acid levels (χ²=1465.4, df=4, p-value<0.001), with the early reduction observed as early as the second visit. The incidence of allopurinol-related adverse reactions was 4.37% (385/8801 cases). Conclusion: The current dosing regimen of allopurinol at Songklanagarind Hospital has demonstrated favorable treatment outcomes and continues to be effective. This data provides insights into pharmacological management and its real-world outcomes.
PENGARUH KEPEMIMPINAN DAN PELATIHAN TERHADAP KOMPETENSI DIGITAL YANG DIMEDIASI OLEH MOTIVASI PADA PEGAWAI KANTOR PERWAKILAN BANK INDONESIA PROVINSI RIAU
Authors: Irawati Yunelda , Hendriani Susi , Setiawan Deny
Published: September 2024

Seiring perkembangan teknologi yang mengakselerasi digitalisasi sektor keuangan, dan untuk mencapai SDM berkinerja tinggi dan produktif maka Bank Indonesia fokus kepada peningkatan kompetensi khususnya kompetensi digital. Saat ini terdapat tantangan pelatihan SDM harus sejalan dengan megatrend digital dan proses bisnis digital. Selain itu perlu hadirnya tokoh leader yang tidak statis, namun agile dan berkomitmen tinggi untuk mengembangkan nilai-nilai transformasi organisasi. Bank Indonesia juga perlu menjaga motivasi pegawai yang dapat mendukung terwujudnya SDM kompeten, profesional dan berkinerja tinggi. Penelitian ini bertujuan untuk menganalisis dan meneliti pengaruh kepemimpinan (X1) dan pelatihan (X2) terhadap kompetensi digital (Y) yang dimediasi oleh motivasi (Z) pada pegawai Kantor Perwakilan Bank Indonesia Provinsi Riau, dengan pendekatan kuantitatif. Pengumpulan data dengan teknik sampling jenuh kepada 50 orang pegawai dan alat analisis data PLS-SEM.
Hasil penelitian menunjukkan bahwa (1) kepemimpinan berpengaruh negatif dan tidak signifikan terhadap kompetensi digital, sehingga harus dimediasi variabel lain untuk membangun kesadaran pegawai terhadap nilai kerjanya dan mengupayakan  kompetensi optimalnya; (2) kepemimpinan berpengaruh positif dan signifikan terhadap motivasi; (3) pelatihan berpengaruh positif dan tidak signifikan terhadap kompetensi digital; (4) pelatihan berpengaruh positif dan signifikan terhadap motivasi; (5) motivasi berpengaruh positif dan signifikan terhadap kompetensi digital; (6) kepemimpinan berpengaruh positif dan signifikan terhadap kompetensi digital melalui variabel motivasi; dan (7) pelatihan berpengaruh positif dan signifikan terhadap kompetensi digital melalui variabel motivasi.
Selanjutnya disarankan perlunya memperkuat peranan pimpinan dalam menjalankan keseluruhan fungsi-fungsi dalam manajemen organisasi secara efektif, serta meningkatkan efektivitas asesmen kompetensi di satuan kerja.
Kata kunci : kompetensi digital, motivasi, kepemimpinan, pelatihan.
Pengaruh Kompetensi Sumber Daya Manusia Dan Motivasi Terhadap Kinerja UMKM Sektor Kuliner Di Kecamatan Payung Sekaki di Kota Pekanbaru Dengan Dukungan Pemerintah Sebagai Variabel Moderasi
Authors: Ananda Salsabilla , Lestari Garnasih Raden , Fitri Kurniawaty
Published: September 2024

This research aims to determine the influence of Human Resource Competency and Motivation on the Performance of Culinary MSMEs in Payung Sekaki sub-district with Government Support as moderating variable. The population in this study was culinary MSMEs located in the Payung Sekaki sub-district, Pekanbaru City, totaling 705 people. By using the Slovin formula, the number of samples used in this research was 88 respondents. The data collection technique uses a questionnaire distribution method, to test the hypothesis in this research using Structural Equation Modeling - Partial Least Square (SEM-PLS) with the help of the SmartPLS 3.0 program. The sampling technique was carried out using a purposive sampling method and 88 owners were selected as samples. The results of this research show that: 1) There is a positive and significant influence between Human Resource Competence on the Performance of Culinary MSMEs, 2) There is a positive and significant influence between Motivation on the Performance of Culinary MSMEs, 3) There is no significant influence between Human Resource Competence on Performance of Culinary MSMEs moderated by Government Support, 4) There is no significant influence between Motivaton on the Performance of Culinary MSMEs moderated by Government Support.
Analisa Pengaruh Foreign Direct Investment terhadap Nilai Tambah Industri Pengolahan di Indonesia
Authors: Azwin Alfarizsy Ahmad , Ekananda Mahyus
Published: September 2024

This study aims to measure the effect of Foreign Direct Investment to value-added of manufacturing industry in Indonesia. This study uses data from 24 manufacturing sub-sectors according to the Indonesian Standard Industrial Classification. The data used in this study are: FDI and PMDN realization data (sourced from BKPM); data of value added, labor, fixed capital, production input costs and labor expenditures (sourced from Central Bureau of Statistic). The estimation method used is Feasible Generalized Least Square with Fixed Effect, with a period of years from 2009 to 2019. The results of this study indicate that FDI and several related variables have a significant positive effect on the value added of the manufacturing industry in Indonesia.
PENGARUH PENAMBAHAN IKAN TAMBAN (Sardinella lemuru) TERHADAP PEMBUATAN CHOUX PASTRY
Authors: Ilahi Wahyuni Julita Putri , Putri R. Marwita Sari , Apriandi Azwin
Published: September 2024

Saat ini variasi pengembangan choux pastry masih sangat terbatas. Salah satu cara pengembangan produk ini adalah pembuatan choux pastry dengan penambahan ikan tamban. Pemanfaatan daging ikan tamban pada choux pastry diharapkan mengandung kualitas serta kandungan gizi yang baik. Selain itu, penggunaan protein yang terkandung dalam ikan tamban pada pembuatan choux pastry mampu menghasilkan produk dengan cita rasa gurih. Tujuan dari penelitian ini yaitu untuk menentukan dan mengetahui formulasi terbaik dari penambahan ikan tamban pada choux pastry berdasarkan uji hedonik serta menentukan karakteristik fisik dan nutrisi dari choux pastry yang terpilih berdasarkan uji hedonik. Metode Penelitian ini menggunakan Rancangan Acak Lengkap (RAL), yang terdiri dari empat perlakuan, yaitu IK0 (0%), IK1 (15%), IK2 (20%), IK3 (25%). Hasil pengujian hedonik menunjukkan bahwa pada perlakuan IK3 dengan penambahan ikan 25% mendapatkan hasil terbaik dengan nilai parameter warna (2,50%), aroma (2,66%), rasa (2,79%) dan tekstur (2,66%). Nilai proksimat yang dihasilkan dari hasil uji hedonik yang terpilih mendapatkan nilai kadar air (8,41%), kadar abu (3,81%), kadar protein (20,37%), kadar lemak (37,77%) dan kadar karbohidrat (32,80%).
KARAKTERISTIK ARTIFICIAL NORI DARI DAUN BERUWAS LAUT (Scaevolla taccada)
Authors: Hidayu Putri Mas , Jumsurizal Jumsurizal , Ilhamdy Aidil Fadli
Published: September 2024

Daun beruwas laut (Scaevolla taccada) termasuk tanaman pesisir tumbuh yang umum ditemui di Kepulauan Riau. Berdasarkan penelusuran literatur daun beruwas laut (S. taccada) ini belum pernah diolah menjadi makanan ataupun cemilan. Daun beruwas laut ini memiliki potensi sebagai bahan utama untuk pembuatan Artificial nori karena memiliki warna hijau seperti nori komersial namun tanaman ini tidak menghasilkan gel sebagai pengikat untuk membentuk lembaran. Sehingga perlu ditambahakan bahan lain yaitu dengan penambahan tepung tapioka. Tujuan dari penelitian ini yaitu untuk menentukan formulasi terbaik dari artificial nori dari daun (S. taccada), menentukan karakteristik artificial nori dari daun (S. taccada) serta mengetahui kandungan proksimat artificial nori dari daun (S. taccada). Metode penelitian ini menggunakan rancangan acak lengkap (RAL) dengan menggunakan SPSS 26, yang terdiri dari 3 perlakuan yaitu F1 (6%), F2 (8%), F3 (10%). Hasil pengujian organoleptik menunjukkan bahwa F1 (6%) merupakan perlakuan terbaik memberikan nilai rata-rata terhadap parameter warna (2,53%), aroma (2,57%), rasa (2,73%) dan tekstur (2,40%). Nilai proksimat yang dihasilkan dari uji hedonik terpilih mendapatkan nilai rata-rata kadar air (8,81%), abu (5,06%), protein (13,6%), lemak (3,81%), karbohidrat (68,7%). Ketebalan 1,40 mm, ukuran 3,5x2,3 cm, dan berat 0,2881 gr.
PEMANFAATAN BUAH PANDAN LAUT (Pandanus tectorius) SEBAGAI MINUMAN FUNGSIONAL
Authors: Siagian Herman , Putri R. Marwita Sari , Amrizal Sri Novalina
Published: September 2024

Pandanus tectorius atau pandan tikar adalah tumbuhan liar dipesisir pantai yang memiliki potensi untuk diolah sebagai minuman fungsional karena mengandung kandungan air, karbohidrat, serat. Berdasarkan penelusuran literatur buah pandan laut (Pandanus tectorius) belum pernah diolah sebagai minuman fungsional. Penelitian ini bertujuan untuk mengetahui kandungan minuman fungsional buah pandan laut (Pandanus tectorius) seperti kandungan proksimat, serat. Penelitian ini dilakukan dalam beberapa tahapan, antara lain pembuatan formulasi minuman fungsional, uji Hedonik, uji proksimat, uji kadar serat. Analisis data menggunakan analisis kualitatif dan kuantitatif yang dijelaskan secara deskriptif. Hasil dari penelitian dapat disimpulkan bahwa formulasi minuman fungsional buah pandan laut terbaik berdasarkan uji Hedonik adalah formulasi MP 3 dengan konsentrasi 80% sari buah pandan laut, 10% jeruk kalamansi (Citrus microcarpa) 10% tepung alginat. Hasil analisis proksimat minuman fungsional pada komponen kadar protein 0,42%, dan kadar serat 2,03%.
EVALUASI MUTU RUSIP IKAN TERI NASI (Stolephorus sp.) DENGAN LAMA FERMENTASI YANG BERBEDA
Authors: Hara Frida Kareri , Meiyasa Firat
Published: September 2024

Ikan teri nasi (Stolephorus sp.) adalah ikan pelagis kecil yang hidup di permukaan laut yang dapat dimanfaatkan sebagai sumber pangan. Pengolahan ikan teri nasi sebagai pangan fermentasi khususnya produk rusip sampai saat ini belum dilaporkan, sementara diketahui bahwa ikan teri nasi memiliki komponen kimia yang cukup tinggi. Tujuan dari penelitian ini adalah untuk menganalisis  komposisi kimia seperti kadar air, kadar abu, kadar lemak, kadar protein, kadar karbohidrat rusip ikan teri teri nasi dengan lama fermentasi yang berbeda. Berdasarkan hasil penelitian menunjukkan bahwa komposisi kimia rusip ikan teri nasi (Stolephorus sp.) dengan lama fermentasi yang berbeda memiliki nilai kadar air 72.85 - 74.41%, abu 10.69 - 10,82%, lemak 12.90 - 13,59%, protein 31.06 - 34,68%, karbohidrat 11.43 – 11.58% dan pH sebesar 6.18 - 6.38%. Dengan demikian rusip ikan teri nasi ini berpotensi untuk dikembangkan sebagai pangan fungsional.
Financiamiento del capital de trabajo y competitividad, un estudio de las Pymes del Distrito Metropolitano de Quito en Ecuador
Authors: García Aguilar Juanita del Carmen , Arauz Limaico Camila Estefanía , Bayas Villamarín Alejandro , Estrella Paredes Carlos Manuel , Ballesteros Trujillo Lenin Antonio , Sampedro Zapata Anabella Gilda
Published: September 2024

Introducción: La investigación examinó la relación entre las estrategias de financiamiento de capital de trabajo y las de competitividad en las PYMES del sector manufacturero en el DMQ, Ecuador. Metodología: Se empleó un enfoque mixto, con un diseño no experimental, transversal y longitudinal, utilizando una muestra de 344 empresas. Resultados: Los resultados indican que las PYMES en el periodo 2020-2022 debido a la inestabilidad económica, predominó una estrategia conservadora. La estrategia de competitividad que prevalece entre estas empresas es el liderazgo en costos. Discusión: Además, el análisis estadístico reveló que no existe una relación fuerte, directa y significativa entre las variables de estudio. Conclusión: Se concluye que, en épocas de inestabilidad económica, las compañías adoptan una estrategia de financiamiento conservadora, buscando minimizar riesgos y asegurar la solvencia operativa. Por el contrario, durante la recuperación económica, utilizan un enfoque agresivo, aprovechando las oportunidades de crecimiento y expansión. En este grupo de empresas predomina el liderazgo en costos y sus características asociadas como son control de costos y procesos, inversión en investigación de mercados, sistema de inventivos en ventas, proveedores estratégicos e inversión en tecnología adecuada. La falta de relación entre las variables, sugiere la influencia de otros factores internos o externos en la competitividad empresarial.
Desafiando el poder institucional de la frontera: El videoensayo como herramienta crítica en la obra de Ursula Biemann
Authors: Ruiz Bañón María Luz
Published: September 2024

Introducción: Las fronteras son espacios donde se ejercen políticas, leyes y prácticas que regulan el movimiento de personas, bienes e información. Estas reglas son determinadas por instituciones estatales y supranacionales, que imponen su control, haciendo de las fronteras lugares donde el poder institucional se manifiesta de manera tangible. La artista Ursula Biemann, en su obra “Performing the Border”, utiliza el videoensayo para desafiar y criticar las estructuras de poder institucionales en estos espacios liminales. Metodología: A través del análisis cualitativo de la obra, se han analizado las distintas técnicas narrativas implementadas para generar dicha crítica. Resultados: El estudio visibiliza como la artista pone en evidencia las condiciones inhumanas y las violencias estructurales a las que se enfrentan las personas en la frontera, invitando a la reflexión crítica. Discusión: La obra se relaciona con otros estudios que destacan el videoensayo como una herramienta para la crítica institucional, la resignificación de fronteras, y el activismo social. Conclusiones: “Performing the Border” no solo documenta estas realidades, sino que también ofrece una crítica profunda que desafía las estructuras de poder institucionales, destacando la importancia del arte y el videoensayo, como herramientas para cuestionar y transformar las estructuras de poder en las sociedades contemporáneas.
Pavel Petrovich Parenago and his name in science
Authors: Kuznetsova I. V. , Prokhorov М. E.
Published: September 2024

A brief biography of one of the founders of Stellar Astronomy as a science, Pavel Petrovich Parenago, is given. The question of which scientific phenomena and objects in astronomy bear his name is considered.
Profiles and some dynamic parameters of a layered inhomogeneous elliptical galaxy
Authors: Gasanov S. А.
Published: September 2024

Several new models of a layered inhomogeneous elliptical galaxy (EG) having the shape either a triaxial ellipsoid or an oblate or prolate spheroid and consisting of baryonic mass and dark matter with different laws of density distribution — profiles. Based on these models, some key dynamic parameters of the EG were determined: gravitational (potential) energy and rotational kinetic energy, total surface brightness, total luminosity, and velocity dispersion depending on the distance to the EG center. The relationships between the important dynamic parameters of the galaxy have been established: “mass-dimensions”, “mass-velocity dispersion”, “size-dispersion speeds–luminosity” (surface brightness). Evolutionary scenarios for the formation of EG were studied according to these models. The results obtained were applied to sixty model EGs with parameters exactly matching those that actually exist and are presented in the form of tables.