bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of flaxseed (Linum usitatissimum) on climacteric symptoms and clinical parameters in post-menopausal women
Authors: Kawa Dizaye  , Adeeb Alchalabi , Dereen , Marouf Bushra Hassan
Published: June 2023

Menopause is the irreversible and permanent cessation of menstruation after one year of amenorrhea. Common symptoms include vaginal dryness, hot flashes, night sweating, and bone pain. Traditionally Linum usitatissimum (Flaxseeds) has been used for the treatment of postmenopausal symptoms. However, the effect of this medicinal herb on the satiety hormone; leptin and body weight in menopausal women has not been elucidated well.  This study was designed to evaluate the effect of flaxseeds on serum estrogen, progesterone, leptin, and malondialdehyde, body mass index, blood pressure in menopausal women. Moreover, the flaxseed effect on climacteric symptoms was also investigated.

The study was carried out as an interventional pre-post design. The study was a six-week oral administration of 1000 mg flaxseed powder twice daily by menopausal women. The duration of the study was eight months. Serum levels of estrogen, progesterone, and leptin hormones as well as total plasma malondialdehyde were determined pre-and-post flaxseed intervention. Clinical symptoms and bothersome complaints of postmenopausal women such as hot flashes, vaginal dryness, bone pain, and night sweating were also evaluated. Furthermore, blood pressure elements and body mass index were also measured. The results showed that Linum usitatissimum seed powder significantly reduced vaginal dryness, hot flashes, bone pain, and night sweating in menopausal women. The same dose of flaxseed had no significant effects on serum estrogen and progesterone. However, it significantly decreased serum malondialdehyde and increased serum leptin. Flaxseed had a non-significant effect on body mass index and blood pressure. In conclusion Linum usitatissimum seed had significant efficacy in relieving vasomotor symptoms, decreasing oxidative stress, and increasing serum levels of leptin in menopausal women.

Keywords: climacteric, estrogen, progesterone, leptin, malondialdehyde.
Malaysian In-Service Teachers’ Intrinsic and Extrinsic Motivation towards Teaching English
Authors: Ismail Shajna , Zubairi Ainol Madziah , Paramboor Jafar
Published: June 2023

The most extensively studied second language in the world, English is the language of the global economy. It is crucial to understand whether instructors are sufficiently motivated at different stages of their professional journeys because good teaching is a prerequisite for students' learning. This study aimed at investigating the overall motivation of in-service English language teachers in Malaysia. Employing a quantitative research design, a survey instrument was used to collect data from in-service English teachers who are currently doing their undergraduate degree. They were requested to respond to the items on motivation, which are categorized into two sub-dimensions, intrinsic and extrinsic. The study reveals that Malaysian in-service English teachers are generally motivated to teach English, whereas the motivation comes mostly from the intrinsic aspects. The findings have significant implications on the Malaysian educational policy and system as well as its various professional development programs for teachers generally, and English teachers specifically.
AGROECOLOGIA E PRODUÇÃO DE ALIMENTOS
Authors: Miletto Milene Ferreira , Robaina José Vicente Lima
Published: June 2023

Garantir a segurança alimentar da população representa uma importante demanda mundial contemporânea, por isso propomos pensar a Agroecologia como alternativa na produção de alimentos e desenvolvimento rural. Refletir sobre essa temática requer a compreensão de diversas relações, demandando um olhar interdisciplinar que abarque as dimensões contidas nesse contexto. O presente estudo relata uma pesquisa do tipo intervenção pedagógica, a partir da aplicação de uma Ilha Interdisciplinar de Racionalidade com alunos do Ensino Médio em uma escola do campo, discutindo a temática da Agroecologia. Os instrumentos utilizados foram produções e falas dos participantes, diário de campo e entrevista em grupo focal, analisados através da Análise de Conteúdo de Bardin, através das categorias: IIR- Relato e discussão da atividade, dificuldades encontradas na aplicação da IIR, construções interdisciplinares, questões controversas emergentes.  Os resultados sinalizaram as possibilidades da temática como fomentadora de construções interdisciplinares envolvendo questões controversas e contribuindo com discussões pertinentes para o contexto da Educação do Campo.
RELATO DE EXPERIÊNCIA
Authors: Heck Miriam Ferrazza
Published: June 2023

O presente artigo apresenta os resultados de uma prática pedagógica que foi desenvolvida no decorrer do ano letivo de 2021, em uma escola Estadual de Ensino Médio, localizada no município de Ijuí/ RS. O objetivo principal foi proporcionar aos estudantes possíveis aplicações dos conceitos relacionados com a Matemática Financeira e Estatística, por meio de situações- problemas envolvendo aspectos da realidade. Participaram da intervenção os alunos de duas turmas de terceiros anos do Ensino Médio. Metodologicamente a intervenção pedagógica, possui características de um estudo de caso, com aspectos de uma pesquisa qualitativa. Inicialmente foram estudados em aula os conceitos de Matemática Financeira (juros simples, compostos, descontos, taxas equivalentes, estudo de montantes com aplicações simples e compostas) e Estatística, assim como, foram desenvolvidas atividades sobre estes conteúdos, posteriormente foi utilizado o jogo de trilha, o qual foi disponibilizado, tanto na forma presencial, como na virtual, para os alunos que em função da pandemia do Coronavírus (COVID-19) estavam estudando remotamente pela plataforma Google (Classroom). O jogo possibilitou aos alunos pôr em prática os conteúdos de Matemática Financeira e Estatística de forma divertida e interativa, contribuindo positivamente com a aprendizagem destes respectivos conhecimentos matemáticos.
ÇOK KANALLI SES MİKSAJINDA REVERB KULLANIMI
Authors: YÜCEL İsmet Emre
Published: June 2023

Müzik prodüksiyonunda reverb’ler kapalı mekanların tınısal imzası olan yansışımın/yankılamanın oluşturulması ve mevcut sinyal akışına eklenmesine olanak sağlayan en önemli ses işleme araçlarındandır. Reverb’ler müzik eserlerinin yaratılma süreçlerinde ister profesyonel, isterse amatörler tarafından olsun kayıt ve yayınlanma aşamalarına kadar farklı aşamalarda sıklıkla kullanılırlar. Ancak ekolayzır, kompresör, delay gibi ses işleme araçlarından farklı olarak reverb’ler müziği olduğundan duysal açıdan çok daha büyük ve çekici hale getirdikleri için özellikle amatörler tarafından sıklıkla yanlış kullanılırlar. Bu nedenle doğru reverb kullanımı kayıt teknolojileri ile ilgilenen müzisyenler için önemlidir. Bu amaçla bu çalışmada müzik prodüksiyonu perspektifinden çok kanallı kayıtlarda reverb kullanımını iki ve üç reverb’ün sinyal akışına dahil edildiği iki temel senaryo üzerinden tarif edilerek açıklanmıştır.
Increasing Ethical Understanding of the Use of Information Technology Through Digital Literacy Proficiency Training
Authors: Krisnaningsih Erni , Dwiyatno Saleh , Dedi Jubaedi Ahmad , Shafitri Adhe
Published: June 2023

Since the beginning of the 21st century, the development of information technology in the world has continued to develop massively. Hootsuite and We Are Social as of January 2020 as many as 59% of the world's population can already access the Internet. A similar phenomenon occurs also in Indonesia. In the same survey, Hootsuite estimated that the internet is already accessible to 64% of Indonesians, or around 175.4 million people. Meanwhile, a survey conducted by the Indonesian Internet Service Providers Association (APJII) in the second quarter of 2020 showed that internet penetration in Indonesia reached 73.7% or was already accessible to 196.71 million Indonesians (APJII, 2020). The high number of digital viewers has an impact on the increasing number of users of digital services and changes in people's lifestyles. In terms of practicality and efficiency, it is the reason for accessing information. But behind all the sophistication that exists in today's digital world, it certainly has a positive and negative impact on humans. Understanding of proficient ethics Digital literacy is needed as a reference in the use of technology that is growing to be more targeted. The purpose of community service activities (PKM) is to increase understanding of the ethics of using information technology through digital literacy skills training for the community based on digital safety aspects. Training to increase understanding and application of digital literacy ethics will allow the younger generation to participate in today's modern world era. The training was carried out in 3 sub-districts in Serang Regency with a total number of training participants of 172 participants with resources sharing, mentoring, and workshop method approach. Activities (PKM) consist of 5 stages, namely 1). Problem Identification Stage; 2). Preparation of PKM programs; 3) Pkm team debriefing; 4) implementation of PKM and 5). Evaluation based on pretest and posttest questionnaires. The results of the evaluation of PKM activities based on the digital security pillar have increased understanding of the ethics of trainees from the aspect of digital security based on 5 indicators.
Pelatihan Sertifikasi Microsoft Office Specialist (MOS) Bagi Siswa-Siswi SMK Islam Malahayati Jakarta
Authors: Hasan Firman Noor , Moh Yusuf Djeli , Kun Fayakun
Published: June 2023

Educators who have competence in certain areas of expertise will guide their students to have competency in those areas of expertise. Competency in the field of expertise is obtained through a certification exam. The main purpose of competency certification is to ensure a person is competent in their area of expertise through the learning stage as well as the work experience stage. Certifications are usually issued by institutes, organizations, or professional associations that oversee certain professional competencies. This activity is motivated by the following: (1) In general, teachers and students do not know about the importance of competency certification, which is not only recognized nationally but is also recognized on an international scale. (2) In general, teachers and students do not know how to use Microsoft Office tools in accordance with international standards (SI). (3) There are still many students who do not have competency certification, both at the national and international levels. (4) Students do not know the international competency certification exam methods that use the CBT system and simulators that are connected in real-time. This community service activity is in the form of a training method for Microsoft Office Specialist International competency certification, which is divided into several stages. The results of the evaluation questionnaire filled out by the participants resulted in 52.23% feeling very satisfied, while 44.06% of the participants felt agreeable, satisfied, and helped through community service and mentoring activities.
Socialization on Making Infiltration Wells in Halaban Village, Besitang District, Langkat Regency
Authors: Wiwin Nurzanah  , Indrayani  , Irma Dewi
Published: June 2023

Halaban Village is located in Besitang District, Langkat Regency. This village does not have clean water supply facilities, either government or private water treatment plants. This is why the majority of villagers use groundwater for their daily needs. But the groundwater will dry up when the dry season comes. This condition is a problem that has not been resolved until now. The community has to spend quite a lot of money to buy clean water for their daily needs when the dry season comes. This problem encourages the author to help the community by providing appropriate technological knowledge regarding the meaning and benefits of infiltration wells. This media is one way to overcome the problem of water shortages. The method used is a non-formal socialization method so that the knowledge conveyed can be better understood by the community. The results of this socialization are expected to be followed by the construction of infiltration wells in every Halaban village house.
Training on the Implementation of EYD Rules Version V in Writing Scientific Papers for Teachers of Shohwatul Is'ad Islamic Boarding School Pangkep
Authors: Munira Hasjim  , Lukman  , Kaharuddin  , Ita Suryaningsih  , Indarwati
Published: June 2023

The training on the application of the latest version of the Indonesian Language Spelling Standard (EYD V) in writing scientific papers for teachers of Pondok Pesantren Shohwatul Is’ad Pangkep aims to improve their ability to write good and correct scientific papers in accordance with the latest version of EYD. The training was conducted through lectures, discussions, and writing exercises. The results of the training showed an improvement in understanding and application of the latest version of EYD in writing scientific papers. The teachers of Pondok Pesantren Shohwatul Is’ad Pangkep were able to write scientific papers better and correctly, and met the latest version of EYD. The conclusion of this training is the importance of applying the latest version of EYD in writing scientific papers for better understanding and universal recognition.
Keefektifan Metode Filtrasi Sederhana Dalam Menurunkan Kadar Mn (Mangan) Dan (Fe) Besi Air Sumur di Kelurahan Talang Ubi Kabupaten Musi Rawas
Authors: Trianah Yeni , Sani Santi
Published: June 2023

Penelitian ini bertujuan untuk menurunkan kadar Mn dan Fe pada air sumur di kelurahan Talang ubi Kecamatan Megang Sakti Kabupaten Musi Rawas yang memiliki kandungan besi yang masih melebihi ketentuan yang ditetapkan Permenkes No.32 Tahun 2017, kandungan Fe maksimal yang diperbolehkan dalam air bersih adalah 1 mg/L, dan kandungan Mn maksimum adalah 0,4 mg/L. Penelitian ini dilakukan dengan menggunakan 3 sampel air sumur melalui proses filtrasi sederhana dengan media zeolit ​​dan karbon aktif. Diharapkan kandungan Fe dan Mn yang terkandung dalam air sumur dapat diturunkan untuk memenuhi syarat kualitas air bersih. Hasil penelitian menunjukkan bahwa kombinasi media filter zeolit ​​dan karbon aktif efektif dalam menurunkan kadar Fe dan Mn pada air sumur, kadar Fe dan Mn sebelum perlakuan adalah 1,20 mg/l dan 0,90 mg/l, kadar Fe dan Mn setelah perlakuan. yang diberi perlakuan dengan media filter zeolit ​​rata-rata 0,16 mg/l dan 0,14 mg/l, dengan media filter karbon aktif rata-rata kandungan Fe 0,24 mg/l dan rata-rata kandungan Mn 0,24 mg/l, dan menggunakan media filter zeolit ​​dengan bahan aktif karbon dengan kandungan Fe rata-rata 0,18 mg/l dan kandungan Mn rata-rata 0,20 mg/l, kombinasi media filter yang paling efektif dalam menurunkan kadar Fe dan Mn adalah kombinasi media filter zeolit ​​sehingga hasil filtrasi dapat dapat digunakan oleh masyarakat dengan syarat harus diolah terlebih dahulu
Produktivitas Dan Efektivitas Alat Berat Pada Pekerjaan Lapis Pondasi Proyek Rehabilitasi Jalan
Authors: Firda Ani Firda , Asmawi Bazar , Akhirini  , Parlaungan Dolly
Published: June 2023

Keberhasilan suatu proyek dapat diukur dari dua hal, yaitu keuntungan yang didapat serta ketepatan waktu penyelesaian proyek. Hal ini untuk dapat menyelesaikan proyek dengan tepat waktu maka salah satu yang harus diperhatikan adalah pemilihan alat berat. Pada penelitian ini dilakukan untuk mengetahui produktivitas alat berat, biaya dan waktu yang dibutuhkan untuk menyelesaikan pekerjaan lapis pondasi agregat kelas A digunakan metode Bina Marga Tahun 2018. Hasil analisis perhitungan terhadap masing-masing alat berat didapat yaitu : Wheel Loader sebesar 827,58 m3/hari, Dump Truck sebesar 13,73 m3/hari, Motor Grader sebesar 8.495,28 m3/hari, Vibratory Roller = 761,94 m3/hari, Water Tanker sebesar 1.110,88 m3/hari. Sedangkan untuk perhitungan biaya dan waktu yang dibutuhkan pada masing-masing alat berat pada pekerjaan Agregat Kelas A yaitu : Wheel Loader sebesar Rp.5.648.000,00 sebanyak 1 unit selama 2 hari, Dump Truck sebesar Rp.63.648.000,00 sebanyak 26 unit selama 4 hari, Motor Grader sebesar Rp.2.732.000,00 sebanyak 1 unit selama 1 hari, Vibratory Roller sebesar Rp.2.968.000,00 sebanyak 1 unit selama 2 hari, Water Tanker sebesar Rp.1.320.000,00 sebanyak 1 unit selama 2 hari.
Pengujian Terhadap Kekuatan Dan Pelapukan Beton Dengan Pengukuran Kekerasan Dan Karbonasi Dam Concrete Face Dan Spillway Pada Bendungan Cirata
Authors: Novi Andhi Setyo Purwono  , Tiyani Lilis , Sagara Altho , Nasution Multilawati
Published: June 2023

Bendungan merupakan salah satu sarana multifungsi yang memiliki peranan penting bagi kehidupan manusia. Guna menjaga dan meningkatkan jaminan keamanan bendungan dan pengoperasiannya maka diperlukan pemeriksaan teliti (assesment) melalui penerapan metodologi test/pengujian yang memadai. Tujuan dari penelitian ini adalah mengetahui tingkat pelapukan dan kekuatan struktur beton concrete face dan spillway sejak dini guna menghindari kerusakan atau kerugian yang lebih besar dikemudian hari. Pekerjaan pengukuran dengan melakukan pengukuran/pengujian kekuatan beton secara langsung (non destructive – direct test) melalui uji tekan permukaan beton. Hasil dari pengujian hammer test dan karbonasi yang dilakukan di area concrete faced dan pharaphet adalah kuat tekan beton rata-rata pada dam concrete faced adalah sebesar 343 kg/cm2, rata-rata tebal beton yang mengalami karbonasi adalah sebesar 0,5 mm. Kuat tekan beton rata-rata pada dam pharaphet adalah sebesar 391 kg/cm2, rata-rata tebal beton yang mengalami karbonasi adalah sebesar 1 mm. Pengujian non-destructive adalah pengujian dengan schmidt hammer. Hasil pengujian ini adalah kuat tekan beton rata-rata pada spillway inlet adalah sebesar 378 kg/cm2, rata-rata tebal beton yang mengalami karbonasi adalah sebesar 0,83 mm. Kuat tekan beton rata-rata pada outlet spillway adalah sebesar 271 kg/cm2, rata-rata tebal beton yang mengalami karbonasi adalah sebesar 0,55 mm. Kuat tekan beton rata-rata pada bottom spillway outlet adalah sebesar 243 kg/cm2, rata-rata tebal beton yang mengalami karbonasi adalah sebesar 0,55 mm
Experience of organization of tourist-recreation zones in territories with special conditions of environmental management (by the example of Lake Baikal)
Authors: Evstropieva Oksana V.
Published: June 2023

The article discusses the features of organizing tourist and recreational activities in territories with a high degree of territorial and institutional uniqueness, presents a theoretical and methodological approach to identifying and determining the development goals of the territories of priority tourist and recreational development – tourist-recreational zones on the coast of Lake Baikal. Lake Baikal is a territory with special conditions of use, which has unique natural characteristics and a powerful system of environmental and legal regulation of public relations in the field of environmental protection. For effective planning and regulation of recreational activities in the context of strict environmental requirements for biodiversity conservation, an environmental legal mechanism is involved. This allows you to determine the priority right to use the territory, relying on the norms of environmental law. In the geoinformation environment, using the tool of legal ecological zoning, which manifests the effect of all legal norms in a particular area of the territory, tourist-recreational zones have been identified that allow the legitimate development of recreational activities within the established boundaries. The correlation of the current permitted standards of recreational load with the real state of “local ecosystems” allowed zoning of the tourist-recreational zones in terms of the intensity and nature of recreational loads. The selected categories of legal zoning make it possible to clarify the permitted types of activities on the territory within the boundaries of plots of various categories of land and determine the specific purpose of their use, the types of objects that can be placed. Further analysis of the tourist-recreational zones on the resistance of their constituent ecosystems to recreational loads made it possible to determine possible scenarios for the development of the situation and formulate goals for the development of the tourist-recreational zones with detailing to the level of recreational functions of the territories. Selected tourist-recreational zones can be proposed for the formation of specially protected areas of recreational purpose of regional significance on them and included in urban planning and program documents with the subsequent detailing of the territorial structure of tourism and regular monitoring of environmental, social and economic parameters of the development of recreational activities.
Global crisis in the context of law, physical economy and energy value theory
Authors: Shapsugova Marietta D.
Published: June 2023

The transition to new technologies and the energy crisis provoked has become a source of a global economic, political, cultural and civilizational crisis. Against this background, studies of the correlation of energy and technological transitions, as well as their impact on the transformation of socio-economic systems, are of particular relevance. Understanding social, cultural, technological processes and phenomena based on traditional values and accumulated cultural and historical experience is one of the Foundations of the state policy for the preservation and strengthening of traditional Russian spiritual and moral values, approved by Decree of the President of the Russian Federation of November 9, 2022 No. 809. The object of research in the article is the global crisis, and the subject is its specific manifestations: energy, economic, social crises. The purpose of the study is to conduct an experiment on the application of the energy theory of value as a direction of physical economics to the analysis of the global crisis. Based on the goal, the main task of the study is to determine the direction of social development based on the energy theory of value. The article concluded that a civilizational shift is inevitable, the social structure of society is rebuilt, cultural values are rethought, and new universal equivalent - a value meter, as which the author offers the cost of energy.
Designing Children’s Story Book As An Introduction Towards Silek Harimau Martial Art
Authors: Trisno James , Erlyana Yana
Published: June 2023

Indonesia has a martial art, namely the martial art of Pencak Silat. Pencak Silat has various variations due to the diversity of cultures in Indonesia. Unfortunately, Pencak Silat is currently less in demand due to various reasons, but one of them is competition with foreign martial arts. One of the martial arts of Pencak Silat whose existence is threatened is the martial art of Silek Harimau, this is made worse by the absence of written documentation regarding Silek Harimau. Therefore, this design aims to create media in the form of illustrated children's story books that introduce Silek Harimau to children. This design will use descriptive qualitative research methods, and data collection methods in the form of interviews, observations, literature studies, and questionnaire surveys. The design will use the Design Thinking method which consists of various stages, namely: Emphasize, Define, Ideate, Prototype, and Test. These design stages will later produce a media in the form of a illustrated children's story book entitled "Menjadi Kesatria Harimau"

Keywords: martial arts; children; picture book; stories
Visualization of Seeking Identity on Transnational Children In “Be Prepared” Graphic Novel
Authors: Park Johanes
Published: June 2023

Be Prepared is a graphic novel about Vera,  the daughter of immigrants from Russia. In her storyline, Vera faces many cultural challenges when dealing with American and other Russian immigrant children. Vera attempts to find identity amidst the differences between the original culture of Russia and the American culture as the country she lived in. The situation between 2 cultures is a challenge for transnational children. This study aims to analyze and see the meaning represented in the graphic novel, especially how transnational children obtain identity and adapt to their environment. The research method used in this research is semiotics and literature review. The semiotic method is used to see the relationship between signs to get the meaning. The semiotic theories used in this research are based on Roland Barthes’s theories. Another method is the literature review which is conducted by overviewing the signs through several published literature to expand the meanings. The base theory used in the literature review is a cultural study that consists of ideas about acculturation, immigration, and cross-cultural theories. From this research, it can be seen that in the comparison of situations of 2 birthday parties, there are expectations in acculturation. The worship scene in the Russian Orthodox church represents immigrant families' coping mechanism for acculturation stress. The signs seen in the graphic novel are also seen in the acculturation stage of Vera's character to gain identity, which can be divided into three stages, namely, the stage of seeking recognition, the stage of imitating, and the stage of integration.

Keywords: transnationalism; immigrant; acculturation; graphic novel; sequential arts.
Empowering Leadership In Employee Career Establishment (Case Study in East Java Banking)
Authors: Yulia Evi , Safa’atillah Nurus
Published: June 2023

The purpose of this study is to determine the relationship between empowering leadership and career success and the mediating role of psychological empowerment in the process of forming employee careers. The research method used is a quantitative research type with a survey method. The population of banking employees with a research sample of 300 banking employees in East Java. Analysis using PLS SEM. The results of the study show that empowering leadership is positively related to psychological empowerment and career success. besides that psychological empowerment also plays a positive role in mediating the relationship between empowering leadership and career success. This study outlines that psychological empowerment is an effective stimulus in enhancing the relationship between empowering leadership and career success. implications of contributing practically in the development of theories and strategies that can be applied in banking. Additionally future research directions are suggested.
Exact Traveling Wave Solutions of the Schamel-KdV Equation with Two Different Methods
Authors: KARAKOÇ Seydi Battal Gazi , ALİ Khalid K. , MEHANNA Mona
Published: June 2023

The Schamel-Korteweg-de Vries (S-KdV) equation including a square root nonlinearity is very important pattern for the research of ion-acoustic waves in plasma and dusty plasma. As known, it is significant to discover the traveling wave solutions of such equations. Therefore, in this paper, some new traveling wave solutions of the S-KdV equation, which arises in plasma physics in the study of ion acoustic solitons when electron trapping is present and also it governs the electrostatic potential for a certain electron distribution in velocity space, are constructed. For this purpose, the Bernoulli Sub-ODE and modified auxiliary equation methods are used. It has been shown that the suggested methods are effective and give different types of function solutions as: hyperbolic, trigonometric, power,
exponential, and rational functions. The applied computational strategies are direct, efficient, concise and can be implemented in more complex phenomena with the assistant of symbolic computations. The results found in the paper are of great interest and may also be used to discover the wave sorts and
specialities in several plasma systems.
Evaluation of biocompatibility and angiogenic potential of extracellular matrix hydrogel biofunctionalized with the LL-37 peptide
Authors: López-Gutierrez Jorge , Ramos-Payán Rosalío , Romero-Quintana Jose Geovanni , Ayala-Ham Alfredo , Castro-Salazar Yolanda , Castillo-Ureta Hipolito , Jiménez-Gastélum German , Bermúdez Mercedes , Aguilar-Medina Maribel
Published: June 2023

BACKGROUND: Biomaterials must allow revascularization for a successful tissue regeneration process. Biomaterials formulated from the extracellular matrix (ECM) have gained popularity in tissue engineering because of their superior biocompatibility, and due to their rheological properties, ECM-hydrogels can be easily applied in damaged areas, allowing cell colonization and integration into the host tissue. Porcine urinary bladder ECM (pUBM) retains functional signaling and structural proteins, being an excellent option in regenerative medicine. Even some small molecules, such as the antimicrobial cathelicidin-derived LL-37 peptide have proven angiogenic properties. OBJECTIVE: The objective of this study was to evaluate the biocompatibility and angiogenic potential of an ECM-hydrogel derived from the porcine urinary bladder (pUBMh) biofunctionalized with the LL-37 peptide (pUBMh/LL37). METHODS: Macrophages, fibroblasts, and adipose tissue-derived mesenchymal stem cells (AD-MSC) were exposed pUBMh/LL37, and the effect on cell proliferation was evaluated by MTT assay, cytotoxicity by quantification of lactate dehydrogenase release and the Live/Dead Cell Imaging assays. Moreover, macrophage production of IL-6, IL-10, IL-12p70, MCP-1, INF-γ, and TNF-α cytokines was quantified using a bead-based cytometric array. pUBMh/LL37 was implanted directly by dorsal subcutaneous injection in Wistar rats for 24 h to evaluate biocompatibility, and pUBMh/LL37-loaded angioreactors were implanted for 21 days for evaluation of angiogenesis. RESULTS: We found that pUBMh/LL37 did not affect cell proliferation and is cytocompatible to all tested cell lines but induces the production of TNF-α and MCP-1 in macrophages. In vivo, this ECM-hydrogel induces fibroblast-like cell recruitment within the material, without tissue damage or inflammation at 48 h. Interestingly, tissue remodeling with vasculature inside angioreactors was seen at 21 days. CONCLUSIONS: Our results showed that pUBMh/LL37 is cytologically compatible, and induces angiogenesis in vivo, showing potential for tissue regeneration therapies.
Effects of the Multicomponent Cognitive Training Program BrainProtect in Cognitively Healthy Adults: A Randomized Controlled Trial
Authors: Falkenreck Julia Maria , Kunkler Michelle Celine , Ophey Anja , Weigert Hannah , Friese Andrea , Jahr Petra , Nelles Gereon , Kalbe Elke , Polidori M. Cristina
Published: June 2023

Background: Cognitive integrity is a fundamental driver of health. The exact structure of strategies against cognitive impairment is still under debate. Objective: To compare the short-term effects of a multicomponent cognitive training (BrainProtect) with those of general health counseling (GHC) on cognitive abilities and health-related quality of life (HRQoL) in healthy adults in Germany. Methods: In this parallel randomized controlled trial (RCT), 132 eligible cognitively healthy adults (age ≥50 years, Beck Depression Inventory ≤9/63; Montreal Cognitive Assessment ≥26/30) were randomized to either GHC (N = 72) or to intervention with BrainProtect (intervention group, IG; N = 60). IG participants received 8 weekly sessions of 90 min of the group-based BrainProtect program focusing on executive functions, concentration, learning, perception, and imagination, plus nutritional and physical exercise units. Before and after intervention, all participants underwent neuropsychological testing and HRQoL evaluation, blinded for pretest. Results: No significant training effect was observed for the primary endpoint of global cognition as assessed by CERAD-Plus-z Total Score (p = 0.113; ηp2 = 0.023). Improvements in several cognitive subtests were shown in the IG (N = 53) compared to the GHC (N = 62) without adverse events. Differences reached significance for verbal fluency (p = 0.021), visual memory (p = 0.013), visuo-constructive functions (p = 0.034), and HRQoL (p = 0.009). Significance was lost after adjustment, though several changes were clinically relevant. Conclusion: BrainProtect did not significantly impact global cognition in this RCT. Nevertheless, the results of some outcomes indicate clinically meaningful changes, so that a strengthening of the cognitive performance by BrainProtect cannot be excluded. Further studies with larger sample size are needed to confirm these findings.
Synthesis of Novel Magnetic Quercetin-Neuropeptide Nanocomposite as a Smart Nano-Drug Shuttle System: Investigation of Its Effect on Behavior, Histopathological Characteristics, and Expression of MAPT and APP Genes in Alzheimer’s Disease Rats
Authors: Mobasheri Kamelia , Zaefizadeh Mohammad , Ghobeh Maryam , Eidi Akram
Published: June 2023

Background: Alzheimer’s disease (AD) is the most common type of dementia. The drugs introduced for this disease have many side effects and limitations in use, so the production of a suitable herbal medicine to cure AD patients is essential. Objective: The aim of this research is to make a magnetic neuropeptide nano shuttle as a targeted carrier for the transfer of quercetin to the brains of AD model rats. Methods: In this work, a magnetic quercetin-neuropeptide nanocomposite (MQNPN) was fabricated and administered to the rat’s brain by the shuttle drug of the Margatoxin scorpion venom neuropeptide, and will be a prospect for targeted drug delivery in AD. The MQNPN has been characterized by FTIR, spectroscopy, FE-SEM, XRD, and VSM. Investigations into the efficacy of MQNPN, MTT, and real Time PCR for MAPT and APP genes expression were performed. After 7 days treatment with Fe3O4 (Ctr) and MQNPN treatment in AD rat, superoxide dismutase activity and quercetin in blood serum and brain was detected. Hematoxylin-Eosin staining was applied for histopathological analysis. Results: Analysis of data showed that MQNPN increased the activity of superoxide dismutase. The histopathology results of the hippocampal region of AD rats also confirmed their improvement after treatment with MQNPN. MQNPN treatment caused a significant decrease in the relative expression of MAPT and APP genes. Conclusion: MQNPN is a suitable carrier for the transfer of quercetin to the rat hippocampus, and has a significant effect in reducing AD symptoms in terms of histopathology, behavioral testing, and changing the expression of AD-related genes.
Detection of fraudulent marketing of consumer product in social networking services
Authors: Nathezhtha T. , Vaidehi V. , Sangeetha D.
Published: June 2023

In recent days, malicious users try to captivate the consumers using their fraudulent marketing URL post in social networking sites. Such malicious URL posted by fake users in Social Networking Services (SNS) is hard to identify. Therefore, there occurs a need to detect such fraudulent URLs in SNS. In order to detect such URLS, this paper proposes a SNS Fraudulent Detection (SFD) scheme. The proposed SFD scheme includes a Deterministic Finite Automata Tokenization (DFA-T) and Web Crawler (WC) based Neuro Fuzzy System (WC-NFS). DFA-T extracts the URL features and calculates a Penalty Score (PS) based on the malicious words in the extracted URL. The DFA extracted URL features with PS are fed into WC-NFS. Subsequently, the WC fetches the numeric WC-Index (WCI) value from the URLs which are added to the WC-NFS. The existing URL data set is used to identify the malicious web links and suitable machine learning techniques are used to identify the malicious URLs. From the experimental results, it is found that the proposed SFD provides 92.6 % accuracy in classifying the benign from malicious URLs when compared with the existing methods.
Performance analysis of “Injection Moulding Machine” under fuzzy environment through contemporary arithmetic operations on right triangular generalized fuzzy numbers (RTrGFN)
Authors: Kumar Amit , Dhiman Pooja
Published: June 2023

The reliability of an industrial system plays a significant role in new technological era where everyone is concerned about the performance of associated industry. With the frequent demands of the customers, the job of the production industries becomes more tedious to produce the required products at a high rate. To fulfill the customer’s demand, the initial focus of the industries is to work well without any interruption/failure in the entire production process. In this paper, Reliability, Availability, MTTF, MTTR, MTBF, ENOF is proposed for an industrial system namely “Injection moulding machine”. For this, the membership function for right triangular generalized fuzzy numbers (RTrGFN) is proposed with the certain level of confidence. The real data of the Injection moulding machine is taken to validate the proposed methodology. The input data is extracted from the records/maintenance sheets of several years and found uncertainty due to the loss of any information or human mistakes. The parameters of the system like failure rate and repair time is retrieved. Based on data, AND-OR combination for the system is constructed. The lambda-tau methodology along with RTrGFN and its corresponding arithmetic operations is used for the performance analysis of the considered “Injection moulding machine”. For better understanding the results are discussed with the aid of graphs. Also after seeing the result one can conclude that this methodology is one of the best methodology for the performance analysis of a conventional system. Also authors have added the highlights and future scope of the research work at the end of the manuscript.
A belief logarithmic similarity measure based on Dempster-Shafer theory and its application in multi-source data fusion
Authors: Huang Haojian , Liu Zhe , Han Xue , Yang Xiangli , Liu Lusi
Published: June 2023

Dempster-Shafer theory (DST) has attracted widespread attention in many domains owing to its powerful advantages in managing uncertain and imprecise information. Nevertheless, counterintuitive results may be generated once Dempster’s rule faces highly conflicting pieces of evidence. In order to handle this flaw, a new belief logarithmic similarity measure ( BLSM ) based on DST is proposed in this paper. Moreover, we further present an enhanced belief logarithmic similarity measure ( EBLSM ) to consider the internal discrepancy of subsets. In parallel, we prove that EBLSM satisfies several desirable properties, like bounded, symmetry and non-degeneracy. Finally, a new multi-source data fusion method based on EBLSM is well devised. Through its best performance in two application cases, specifically those pertaining to fault diagnosis and target recognition respectively, the rationality and effectiveness of the proposed method is sufficiently displayed.
Helmet-wearing detection with intelligent learning approach
Authors: Huang Ke , Zhang Limin
Published: June 2023

In the construction process, wearing a safety helmet is an important guarantee for personnel safety. However, manual detection is time-consuming, labor-intensive, and unable to provide real-time monitoring. To address this issue, a helmet-wearing detection algorithm has been proposed based on YOLOv5s. The algorithm uses the YOLOv5s network and introduces the CoordAtt coordinate attention mechanism module into its backbone to consider global information and improve the network’s ability to detect small targets. To improve feature fusion, the residual block in the backbone network has been replaced by a Res2NetBlock structure. The experimental results show that compared to the original YOLOv5 algorithm, the accuracy and speed of the self-made helmet data set have improved by 2.3 percentage points and 18 FPS, respectively. Compared to the YOLOv3 algorithm, accuracy and speed have improved by 13.8 percentage points and 95 FPS, respectively, resulting in a more accurate, lightweight, efficient, and real-time helmet-wearing detection.
Detection and elimination of multicollinearity in regression analysis
Authors: Singh Preeti , Singh Sarvpal , Paprzycki Marcin
Published: June 2023

Multicollinearity occurs when there comes a high level of correlation between the independent variables. This correlation creates the problem because the independent variables should be independent. Higher the degree of correlation means more complex problems you will face while fitting the model and interpreting the results. In this paper, we have eliminated the problem of multicollinearity on the basis of Hatvalues. The variables with higher Hatvalues will be removed from the data before fitting the model. This paper presents the comparison of results achieved by the proposed technique and state of the art methods.
Patient-Generated Health Data Interoperability Through Master Patient Index: The DH-Convener Approach
Authors: Jayathissa Prabath , Sareban Mahdi , Niebauer Josef , Hussein Rada
Published: June 2023

Patient-Generated Health Data (PGHD), such as data provided by wearable devices, hold promise to improve health outcomes. However, to improve clinical decision-making, PGHD should be integrated or linked with Electronic Health Records (EHRs). Typically, PGHD data are collected and stored as Personal Health Records (PHRs), outside EHR systems. To address this challenge, we created a conceptual framework for PGHD/EHR interoperability through the Master Patient Index (MPI) and DH-Convener platform. Then, we identified the corresponding Minimum Clinical Data Set (MCDS) of PGHD to be exchanged with EHR. This generic approach can be used as a blueprint in different countries.
Data Quality and Data Quantity: Complements or Contradictions?
Authors: Stausberg Jürgen , Harkener Sonja
Published: June 2023

Although data quality is well defined, the relationship to data quantity remains unclear. Especially the big data approach promises advantages of volume in comparison with small samples in good quality. Aim of this study was to review this issue. Based on the experiences with six registries within a German funding initiative, the definition of data quality provided by the International Organization for Standardization (ISO) was confronted with several aspects of data quantity. The results of a literature search combining both concepts were considered additionally. Data quantity was identified as an umbrella of some inherent characteristics of data like case and data completeness. The same time, quantity could be regarded as a non inherent characteristic of data beyond the ISO standard focusing on the breadth and depth of metadata, i.e. data elements along with their value sets. The FAIR Guiding Principles take into account the latter solely. Surprisingly, the literature agreed in demanding an increase in data quality with volume, turning the big data approach inside out. A usage of data without context – as it could be the case in data mining or machine learning – is neither covered by the concept of data quality nor of data quantity.
“DOMINO – Stop Domestic Violence”. An Educational Mobile Application
Authors: Sakellari Evanthia , Murto Tiina , Häsänen Marjatta , Turunen Timo , Modhwadia Hitesh , Sotto-Mayor De Carvalho Pinto Maria Luisa , Ferreira Dos Santos Maria Anabela , Lagiou Areti
Published: June 2023

Domestic violence affects people of all socioeconomic backgrounds and education levels and can happen to anyone. It is a public health issue that needs to be addressed with health and social care professionals playing an essential role in prevention and early intervention. These professionals need to be prepared through proper education. A European funded project developed “DOMINO - Stop domestic violence” educational mobile application which was piloted among 99 social and/or health care students and professionals. Most of the participants (n= 59, 59.6%) indicated that the DOMINO mobile application was easy to install and over half of them (n=61, 61.6%) would recommend the app. They found it easy to use, and quick access to useful materials and tools. Participants found case studies and the checklist good and useful tools for them. The DOMINO educational mobile application is available open access, in English, Finnish, Greek, Latvian, Portuguese and Swedish, for any stakeholder worldwide who is interested to learn more about domestic violence prevention and intervention.
Preconditions for Implementing a Nursing App to Improve Digital Maturity
Authors: Severinsen Gro-Hilde , Silsand Line , Malm-Nicolaisen Kristian , Pedersen Rune
Published: June 2023

The aim of the paper is to conduct a formative evaluation and assess the implementation of a nursing app using the qualitative TPOM framework to outline how different socio-technical aspects of the process influence digital maturity. The research question is: what are the main socio-technical preconditions for improving digital maturity in a healthcare organization? We conducted 22 interviews and used the TPOM framework for analyzing the empirical data. Exploiting the potential of lightweight technology demands a mature healthcare organization motivated actors’ extensive collaboration, and good coordination of the complex ICT infrastructures. The TPOM categories are used to show the digital maturity of the nursing app implementation in relation to technology, human factors, organization, and the wider macro environment.
An Overview About Connected Medical Devices and Their Risks
Authors: Machal Marlon Luca
Published: June 2023

Connected medical devices may send and receive orders from other devices or networks, such as the internet. A connected medical device is often equipped with wireless connection, allowing it to interface with other devices or computers. Connected medical devices are becoming more popular in healthcare settings because they provide a variety of advantages, such as quicker patient monitoring and more efficient healthcare delivery. Connected medical devices may help doctors make educated treatment decisions, enhance patient outcomes, and lower costs. The usage of connected medical devices is especially beneficial for patients who reside in rural or distant locations, have mobility limitations that make traveling to a healthcare center difficult, or during the COVID-19 epidemic. Monitoring devices, infusion pumps, implanted devices, autoinjectors, and diagnostic devices are among the connected medical devices. Smartwatches or fitness trackers that monitor heart rate and activity levels, blood glucose meters that can upload data to a patient’s electronic medical record, and implanted devices that can be monitored remotely by healthcare practitioners are examples of connected medical devices too. Yet, connected medical devices also carry risks that might jeopardize patient privacy and the integrity of medical records.
Rapid Review on Publicly Available Datasets for Health Misinformation Detection
Authors: Ni Zhenni , Bousquet Cédric , Vaillant Pascal , Jaulent Marie-Christine
Published: June 2023

The proliferation of health misinformation in recent years has prompted the development of various methods for detecting and combatting this issue. This review aims to provide an overview of the implementation strategies and characteristics of publicly available datasets that can be used for health misinformation detection. Since 2020, a large number of such datasets have emerged, half of which are focused on COVID-19. Most of the datasets are based on fact-checkable websites, while only a few are annotated by experts. Furthermore, some datasets provide additional information such as social engagement and explanations, which can be utilized to study the spread of misinformation. Overall, these datasets offer a valuable resource for researchers working to combat the spread and consequences of health misinformation.