bluuebunny/crossref_metadata_2025 huggingface dataset:
Influence of Inter- and Intra-Batch Variability on the Sample Size Required for Demonstration of Equivalent Microstructure of Semisolid Dosage Forms
Authors: Xu Zhengguo , Mangas-Sanjuán Víctor , Merino-Sanjuán Matilde , Merino Virginia , García-Arieta Alfredo
Published: November 2020

Inter- and intra-batch variability of the quality attributes contribute to the uncertainty for demonstrating equivalent microstructure of post-approval changes and generic/hybrids of semisolid topical products. Selecting a representative sample size to describe accurately the in vitro properties of semisolids and to reach enough statistical power to demonstrate similarity between two semisolid topical products is currently challenging. The objective of this work is to establish the number of batches and units per batch to be compared based on different inter-batch and intra-batch variability to demonstrate equivalence in the physical characteristics of the products that ensure a similar microstructure of the semisolid. This investigation shows that the minimum number of batches to be compared of each product is 3 and the minimum number of units per batch could be 6 in the case of low intra- and inter-batch variability. If the products are not identical, i.e., 2.5–5% differences that are expected due to differences in the manufacturing process or the suppliers of excipients, 12 units and 6 batches are needed. If intra- or inter-batch variability is larger than 10%, the number of batches and/or the number of units needs to be increased. As the interplay between inter- and intra-batch variability is complex, the sample size required for each combination of inter- and intra-batch variability and expected difference between products can be obtained in the attached tables.
Application of Focus Variation Microscopy and Dissolution Imaging in Understanding the Behaviour of Hydrophilic Matrices
Authors: Ward Adam , Brown Benedict , Walton Karl , Timmins Peter , Conway Barbara R. , Asare-Addo Kofi
Published: November 2020

Hydrophilic matrix systems can be found in a wide range of extended release pharmaceutical formulations. The main principle of these systems is that upon contact with water, the hydrophilic component swells to form a hydrated gel layer which controls drug release. The following work demonstrates an explorative study into the use of dissolution imaging and focus variation microscopy with hydrophilic polymers. This study investigated the surface properties of xanthan gum (XG), polyethylene oxide (PEO), and hypromellose (hydroxypropyl methylcellulose, HPMC) compacts with each of these three hydrophilic polymers from one of each classification of natural, semi-synthetic, or synthetic polymer using a focus variation instrument. The auto correlation length (Sal) showed all surface profiles from the compacts displayed a value below 0.1 mm, indicating that only high frequency components (i.e., roughness) were considered and that the analysis had been successful. The developed interfacial area ratio (Sdr) displayed values below 5% in line with ISO guidelines for all the polymers studied with their texture aspect ratio values (Str) > 0.5, indicating uniformity of the surfaces of the produced compacts. Of the various parameters studied, areal material ratio (Smr2) predicted XG to wet and hydrate quicker than PEO, with PEO also wetting and hydrating quicker than the HPMC. The dissolution imaging and initial swelling studies proved to concur with the findings from the areal material ratio (Smr2) parameter, suggesting porosity was not an indicator for the ease with which water ingress occurs. This study suggests the Smr2 surface parameter to potentially predict wetting and initial hydration of hydrophilic polymers, however care should be taken as this study consists of a selected number of hydrophilic polymers.
Direct Fluorination as Method of Improvement of Operational Properties of Polymeric Materials
Authors: Belov Nikolay A. , Alentiev Alexander Y. , Bogdanova Yulia G. , Vdovichenko Artem Y. , Pashkevich Dmitrii S.
Published: November 2020

Direct fluorination of polymers is a widely utilized technique for chemical modification. Such introduction of fluorine into the chemical structure of polymeric materials leads to laminates with highly fluorinated surface layer. The physicochemical properties of this layer are similar to those of perfluorinated polymers that differ by a unique combination of chemical resistance, weak adhesion, low cohesion, and permittivity, often barrier properties, etc. Surface modification by elemental fluorine allows one to avoid laborious synthesis of perfluoropolymers and impart such properties to industrial polymeric materials. The current review is devoted to a detailed consideration of wetting by water, energy characteristics of surfaces, adhesion, mechanical and electrical properties of the polymers, and composites after the direct fluorination.
Low-Temperature-Meltable Elastomers Based on Linear Polydimethylsiloxane Chains Alpha, Omega-Terminated with Mesogenic Groups as Physical Crosslinker: A Passive Smart Material with Potential as Viscoelastic Coupling. Part II—Viscoelastic and Rheological Properties
Authors: Horodecka Sabina , Strachota Adam , Mossety-Leszczak Beata , Kisiel Maciej , Strachota Beata , Šlouf Miroslav
Published: November 2020

Rheological and viscoelastic properties of physically crosslinked low-temperature elastomers were studied. The supramolecularly assembling copolymers consist of linear polydimethylsiloxane (PDMS) elastic chains terminated on both ends with mesogenic building blocks (LC) of azobenzene type. They are generally and also structurally highly different from the well-studied LC polymer networks or LC elastomers: The LC units make up only a small volume fraction in our materials and act as fairly efficient physical crosslinkers with thermotropic properties. The aggregation (nano-phase separation) of the relatively rare, small and spatially separated terminal LC units generates temperature-switched viscoelasticity in the molten copolymers. Their rheological behavior was found to be controlled by an interplay of nano-phase separation of the LC units (growth and splitting of their aggregates) and of the thermotropic transitions in these aggregates (which change their stiffness). As a consequence, multiple gel points (up to three) are observed in temperature scans of the copolymers. The physical crosslinks also can be reversibly disconnected by large mechanical strain in the ‘warm’ rubbery state, as well as in melt (thixotropy). The kinetics of crosslink formation was found to be fast if induced by temperature and extremely fast in case of internal self-healing after strain damage. Thixotropic loop tests hence display only very small hysteresis in the LC-melt-state, although the melts show very distinct shear thinning. Our study evaluates structure-property relationships in three homologous systems with elastic PDMS segments of different length (8.6, 16.3 and 64.4 repeat units). The studied copolymers might be of interest as passive smart materials, especially as temperature-controlled elastic/viscoelastic mechanical coupling.
Self-Assembly CNTs@PANi Coffee Rings on Poly(styrene-ethylene-butylene-styrene) Triblock Copolymer for Largely Stretchable Electronics
Authors: Zhu Ming , Zhang Ruifeng , Chen Gang , He Wenjun , Chen Yaowei , Yu Deng-Guang , Li Xiaoyan
Published: November 2020

In this paper, CNTs@PANi nanocomposites were prepared by in-situ oxidation polymerization of aniline, and their structure, morphology and conductivity were characterized. A mixed solvent of toluene and tetrahydrofuran was used to prepare dispersions of CNTs@PANi and poly(styrene-ethylene-butylene-styrene) (SEBS) triblock copolymer, and bilayer composite film was prepared. According to the solvent phase separation and uneven evaporation flux, CNTs@PANi self-assembled into the interconnected coffee ring structure on the SEBS matrix. The prepared bilayer composite film had excellent stretchability, and the conductivity of the functional layer was close to that of CNTs@PANi, which could light up an LED lamp under 100% strain and restore the topological structure. Electrochemical tests showed that the bilayer film had obvious heterogeneity. The impedance characteristics of the CNTs@PANi functional layer and the SEBS matrix were analyzed, and its heterogeneous corrosion resistance mechanism further discussed.
Aragonite-Polylysine: Neuro-Regenerative Scaffolds with Diverse Effects on Astrogliosis
Authors: Morad Tzachy , Hendler Roni Mina , Canji Eyal , Weiss Orly Eva , Sion Guy , Minnes Refael , Polaq Ania Hava Grushchenko , Merfeld Ido , Dubinsky Zvy , Nesher Elimelech , Baranes Danny
Published: November 2020

Biomaterials, especially when coated with adhesive polymers, are a key tool for restorative medicine, being biocompatible and supportive for cell adherence, growth, and function. Aragonite skeletons of corals are biomaterials that support survival and growth of a range of cell types, including neurons and glia. However, it is not known if this scaffold affects neural cell migration or elongation of neuronal and astrocytic processes, prerequisites for initiating repair of damage in the nervous system. To address this, hippocampal cells were aggregated into neurospheres and cultivated on aragonite skeleton of the coral Trachyphyllia geoffroyi (Coral Skeleton (CS)), on naturally occurring aragonite (Geological Aragonite (GA)), and on glass, all pre-coated with the oligomer poly-D-lysine (PDL). The two aragonite matrices promoted equally strong cell migration (4.8 and 4.3-fold above glass-PDL, respectively) and axonal sprouting (1.96 and 1.95-fold above glass-PDL, respectively). However, CS-PDL had a stronger effect than GA-PDL on the promotion of astrocytic processes elongation (1.7 vs. 1.2-fold above glass-PDL, respectively) and expression of the glial fibrillary acidic protein (3.8 vs. and 1.8-fold above glass-PDL, respectively). These differences are likely to emerge from a reaction of astrocytes to the degree of roughness of the surface of the scaffold, which is higher on CS than on GA. Hence, CS-PDL and GA-PDL are scaffolds of strong capacity to derive neural cell movements and growth required for regeneration, while controlling the extent of astrocytic involvement. As such, implants of PDL-aragonites have significant potential as tools for damage repair and the reduction of scar formation in the brain following trauma or disease.
Mechanical and Physical Properties of Short Carbon Fiber and Nanofiller-Reinforced Polypropylene Hybrid Nanocomposites
Authors: Junaedi Harri , Baig Muneer , Dawood Abdulsattar , Albahkali Essam , Almajid Abdulhakim
Published: November 2020

The effect of various combinations of filler materials on the performance of polypropylene (PP)-based composites was investigated. PP in particulate form was used as the matrix. Milled short carbon fiber (SCF) micro-size, graphite nano-platelet (GNP), and titanium dioxide nanoparticles (nTiO2) were used as fillers. These fillers were incorporated in the polymer matrix to produce mono-filler (PP/SCF and PP/nanofiller) and hybrid composites. Hybrid composites consist of PP/10SCF/GNP, PP/10SCF/nTiO2, and PP/10SCF/GNP/nTiO2. The effect of the addition of SCF, GNP, and nTiO2 on PP-based composites was investigated by analyzing their morphological, mechanical, and physical properties. The addition of mono-filler to the PP matrix improved the mechanical properties of the composites when compared to the neat PP. The ultimate tensile strength (UTS), flexural modulus, flexural strength, and impact toughness of the hybrid composites with 15 wt % total loading of fillers, were higher than that of mono-filler composites with 15 wt % SCF (PP/15SCF). A maximum increase of 20% in the flexural modulus was observed in the hybrid composite with 10 wt % of SCF with the additional of 2.5 wt % GNP and 2.5 wt % nTiO2 when compared to PP/15SCF composite. The addition of 2.5 wt % nTiO2 to the 10 wt % SCF reinforced PP, resulted in increasing the strain at break by 15% when compared to the PP/10SCF composite. A scanning electron microscope image of the PP/10SCF composite with the addition of GNP improved the interfacial bonding between PP and SCF compared with PP/SCF alone. A decrease in the melt flow index (MFI) was observed for all compositions. However, hybrid composites showed a higher decrease in MFI.
Investigation of 3D-Moldability of Flax Fiber Reinforced Beech Plywood
Authors: Jorda Johannes , Kain Günther , Barbu Marius-Catalin , Haupt Matthias , Krišťák Ľuboš
Published: November 2020

The current work deals with three dimensionally molded plywood formed parts. These are prepared in two different geometries using cut-outs and relief cuts in the areas of the highest deformation. Moreover, the effect of flax fiber reinforcement on the occurrence and position of cracks, delamination, maximum load capacity, and on the modulus of elasticity is studied. The results show that designs with cut-outs are to be preferred when molding complex geometries and that flax fiber reinforcement is a promising way of increasing load capacity and stiffness of plywood formed parts by respectively 76 and 38% on average.
Chemical Hydrogels Bearing Thiazolium Groups with a Broad Spectrum of Antimicrobial Behavior
Authors: Muñoz-Bonilla Alexandra , Zagora Jakub , Plachá Daniela , Echeverría Coro , Chiloeches Alberto , Fernández-García Marta
Published: November 2020

Several hydrogels based on 2-hydroxyethyl methacrylate and a methacrylic monomer containing a thiazole group in its lateral chain have been prepared by thermal polymerization at 60 °C in water solution varying the chemical composition of the gels. The posterior quaternization of the thiazole groups with methyl iodine has rendered positively charged hydrogels with potential antimicrobial activity. This modification has been structurally characterized by infrared spectroscopy, whereas the thermal stability of all hydrogels has been studied by thermal degradation in inert atmosphere. The swelling behavior in distilled water and the rheology of the different hydrogels have been analyzed as a function of 2-(4-methylthiazol-5-yl)ethyl methacrylate (MTA) monomer content as well as its methylation. Finally, the active character of hydrogels against Gram-positive and Gram-negative bacteria and fungi has been evaluated, revealing excellent antimicrobial activity against all tested microorganisms. The methylated hydrogels could be used as potential materials for wound healing or contact lens applications.
Support or Punishment Practices: What Works to Reduce School Violence
Authors: Crawford Charles , Burns Ronald
Published: November 2020

School culture and violence have garnered much public and scholarly attention in recent years. Research in the area has focused on the extent to which strict enforcement of school policies and the law results in safer schools. Other research focuses on providing more supportive, less enforcement-oriented environments for students. We advance this work by using a sample of 2092 respondents from public schools in the United States from the 2015–2016 school survey on crime and safety from the Department of Education. There were several statistically significant supportive practices that reduced violent incidents and disciplinary actions for violence, and the findings generally suggest that punitive policies were not effective in increasing campus safety while controlling for relevant security practices and school contextual variables.
Suspect and Target Screening of Natural Toxins in the Ter River Catchment Area in NE Spain and Prioritisation by Their Toxicity
Authors: Picardo Massimo , Núñez Oscar , Farré Marinella
Published: November 2020

This study presents the application of a suspect screening approach to screen a wide range of natural toxins, including mycotoxins, bacterial toxins, and plant toxins, in surface waters. The method is based on a generic solid-phase extraction procedure, using three sorbent phases in two cartridges that are connected in series, hence covering a wide range of polarities, followed by liquid chromatography coupled to high-resolution mass spectrometry. The acquisition was performed in the full-scan and data-dependent modes while working under positive and negative ionisation conditions. This method was applied in order to assess the natural toxins in the Ter River water reservoirs, which are used to produce drinking water for Barcelona city (Spain). The study was carried out during a period of seven months, covering the expected prior, during, and post-peak blooming periods of the natural toxins. Fifty-three (53) compounds were tentatively identified, and nine of these were confirmed and quantified. Phytotoxins were identified as the most frequent group of natural toxins in the water, particularly the alkaloids group. Finally, the toxins identified to levels 2 and 1 were prioritised according to their bioaccumulation factor, biodegradability, frequency of detection, and toxicity. This screening and prioritisation approach resulted in different natural toxins that should be further assessed for their ecotoxicological effects and considered in future studies.
Zika Virus Infection in a Cohort of Pregnant Women with Exanthematic Disease in Manaus, Brazilian Amazon
Authors: Redivo Elijane de Fátima , Bôtto Menezes Camila , da Costa Castilho Márcia , Brock Marianna , da Silva Magno Evela , Gomes Saraiva Maria das Graças , Alvarez Fernandes Salete Sara , Costa Antony de Andrade Anny Beatriz , Costa Alecrim Maria das Graças , Martinez-Espinosa Flor Ernestina
Published: November 2020

The epidemic transmission of Zika virus (ZIKV) in Brazil has been identified as a cause of microcephaly and other neurological malformations in the babies of ZIKV-infected women. The frequency of adverse outcomes of Zika virus infection (ZIKVi) in pregnancy differs depending on the characteristics of exposure to infection, the time of recruitment of research participants, and the outcomes to be observed. This study provides a descriptive analysis—from the onset of symptoms to delivery—of a cohort registered as having maternal ZIKVi in pregnancy, from November 2015 to December 2016. Suspected cases were registered at a referral center for infectious and tropical diseases in Manaus, in the Amazonian region of Brazil. Of 834 women notified, 762 women with confirmed pregnancies were enrolled. Reverse-transcriptase polymerase chain reaction (RT-PCR) confirmed ZIKVi in 42.3% of the cohort. In 35.2% of the cohort, ZIKV was the sole infection identified. Severe adverse pregnancy outcomes (miscarriage, stillbirth, or microcephaly) were observed in both RT-PCR ZIKV-positive (5.0%) and ZIKV-negative (1.8%) cases (RR 3.1; 95% IC 1.4–7.3; p < 0.05), especially during the first trimester of pregnancy (RR 6.2, 95% IC 2.3–16.5; p < 0.001). Although other infectious rash diseases were observed in the pregnant women in the study, having confirmed maternal ZIKVi was the most important risk factor for serious adverse pregnancy events.
The Relevance of MicroRNAs in the Pathogenesis and Prognosis of HCV-Disease: The Emergent Role of miR-17-92 in Cryoglobulinemic Vasculitis
Authors: Lorini Serena , Gragnani Laura , Zignego Anna Linda
Published: November 2020

Hepatitis C virus (HCV) is a major public health problem. HCV is a hepatotropic and lymphotropic virus that leads to hepatocellular carcinoma (HCC) and lymphoproliferative disorders such as cryoglobulinemic vasculitis (CV) and non-Hodgkin’s lymphoma (NHL). The molecular mechanisms by which HCV induces these diseases are not fully understood. MicroRNAs (miRNAs) are small non-coding molecules that negatively regulate post-transcriptional gene expression by decreasing their target gene expression. We will attempt to summarize the current knowledge on the role of miRNAs in the HCV life cycle, HCV-related HCC, and lymphoproliferative disorders, focusing on both the functional effects of their deregulation as well as on their putative role as biomarkers, based on association analyses. We will also provide original new data regarding the miR 17-92 cluster in chronically infected HCV patients with and without lymphoproliferative disorders who underwent antiviral therapy. All of the cluster members were significantly upregulated in CV patients compared to patients without CV and significantly decreased in those who achieved vasculitis clinical remission after viral eradication. To conclude, miRNAs play an important role in HCV infection and related oncogenic processes, but their molecular pathways are not completely clear. In some cases, they may be potential therapeutic targets or non-invasive biomarkers of tumor progression.
Application of the SCS–CN Method to the Hancheon Basin on the Volcanic Jeju Island, Korea
Authors: Kang Minseok , Yoo Chulsang
Published: November 2020

This study investigates three issues regarding the application of the SCS–CN (Soil Conservation Service–Curve Number) method to a basin on the volcanic Jeju Island, Korea. The first issue is the possible relation between the initial abstraction and the maximum potential retention. The second is the determination of the maximum potential retention, which is also closely related to the estimation of CN. The third issue is the effect of the antecedent soil moisture condition (AMC) on the initial abstraction, maximum potential retention and CN. All of these issues are dealt with based on the analysis of several rainfall events observed in the Hancheon basin, a typical basin on Jeju Island. In summary, the results are that, firstly, estimates of initial abstraction, ratio λ, maximum potential retention, and CN were all found to be consistent with the SCS–CN model structure. That is, CN and the maximum potential retention showed a strong negative correlation, and the ratio λ and the maximum potential retention also showed a rather weak negative correlation. On the other hand, a significant positive correlation was found between CN and the ratio λ. Second, in the case where the accumulated number of days is four or five, the effect of antecedent precipitation amount is clear. The antecedent five-day rainfall amount for the AMC-III condition is higher than 400 mm, compared to the AMC-I condition of less than 100 mm. Third, an inverse proportional relationship is found between the AMC and the maximum potential retention. On the other hand, a clear linear proportional relation is found between the AMC and CN. Finally, the maximum potential retention for the Hancheon basin is around 200 mm, with the corresponding CN being around 65. The ratio between the initial abstraction and the maximum potential retention is around 0.3. Even though these results are derived by analyzing a limited number of rainfall events, they are believed to properly consider the soil characteristics of Jeju Island.
Quantitative Estimation of Soil-Ground Water Storage Utilization during the Crop Growing Season in Arid Regions with Shallow Water Table Depth
Authors: Zhao Tianxing , Zhu Yan , Wu Jingwei , Ye Ming , Mao Wei , Yang Jinzhong
Published: November 2020

Water storage in unsaturated and saturated zones during the crop non-growing season is one of the important supplementary water resources to meet crop water requirements in arid areas with shallow water table depth. It is necessary to analyze utilization of the soil-ground water storage during the crop growing season and its attribution to irrigation during the non-growing season. To facilitate the analysis, a new method based on measurements of soil moisture content and water table depth is developed. The measurements used in this study include (1) 15-year data of soil moisture content within a depth of 1 m from the land surface and water table depth measured in Jiefangzha, including its four subareas and (2) 4-year data of the same kind in Yonglian, located in arid northern China. The soil-ground water storage utilization is calculated as the difference of water storage between the beginning and end of the crop growing season in the whole computational soil profile. The results of average soil-ground water storage utilization in Jiefangzha and its four subareas and Yonglian are 121 mm, 126 mm, 113 mm, 124 mm, 185 mm and 117 mm, and the corresponding average utilization efficiencies in the non-growing season are 32.2%, 32.5%, 31.5%, 31.6%, 57.3% and 47.6%, respectively. Further, the water table fluctuation method was used to estimate the variation in water storage. The coefficients of soil-ground water storage utilization, soil-ground water storage utilization below 1 m soil depth and ground water utilization are defined, and their average values are 0.271, 0.111 and 0.026 in Jiefangzha, respectively. Then, the contribution of soil-ground water storage utilization to actual evapotranspiration is evaluated, which are over 23.5% in Jiefangzha and Yonglian. These results indicate that the soil-ground water storage plays an important role in the ecological environment in arid areas with shallow water table depth.
Inappropriate direct oral anticoagulant prescriptions in patients with non-valvular atrial fibrillation: cross-sectional analysis of the French CACAO cohort study in primary care
Authors: Ferrat Emilie , Fabre Julie , Galletout Philippe , Boutin Emmanuelle , Le Breton Julien , Renard Vincent , Frappé Paul , Bastuji-Garin Sylvie
Published: November 2020

Background

Direct oral anticoagulants (DOACs) account for an increasing proportion of prescriptions in patients with non-valvular atrial fibrillation (NVAF) in primary care. Inappropriate dosing of DOACs is a common problem, with under-dosing being a particular issue. However, conflicting results have been reported about the factors independently associated with inappropriate dosing.

Aim

To describe inappropriate prescriptions of DOACs among patients in the CACAO French nationwide general practice cohort, and to identify the factors independently associated with inappropriate DOAC doses.

Design and setting

Cross-sectional baseline analysis of the CACAO French national multicentre prospective cohort of adult patients in primary care receiving an oral anticoagulant who were recruited between April and October 2014.

Method

A total of 1111 patients from the CACAO cohort who received a DOAC for NVAF were included in this study. Inappropriate prescriptions of DOACs were described (inappropriate dosage, contraindications, non-indications, interactions, and non-compliance with the precautions for use). Multivariate logistic models were used to investigate factors associated with inappropriate DOAC dosing (under-dosing and over-dosing).

Results

Overall, 438 patients (39.4%) received at least one inappropriate DOAC prescription. The most common inappropriate prescription was inappropriate dosage (n = 374, 33.7%), particularly under-dosing (n = 348, 31.3%). Multivariate analysis revealed that factors independently associated with under-dosing were older age, prescription of apixaban or dabigatran, and a CHA2DS2-VASc score ≥2 vs. a score = 1. Factors with over-dosing were kidney failure, a HAS-BLED score ≥3, and older age.

Conclusion

The appropriateness of DOAC prescribing for NVAF can be improved, especially in older patients, and in patients with kidney failure, a higher risk of ischaemic stroke, and/or a higher risk of bleeding. GPs have a key role in increasing the proportion of appropriate DOAC prescriptions via informational, educational, and/or management strategies.
O Conservatório de Música Lia Salgado e os processos de subjetivação
Authors: Ferrari Anderson , Ferreira Sales Ereny
Published: November 2020

Com este texto queremos problematizar os processos de subjetivação entendendo-os como educativos, na medida em que são responsáveis pela constituição de sujeitos, envolvendo mecanismos de construção cultural e social. Para isso, elegemos o Conservatório de Música Lia Salgado como campo privilegiado de investigação, dada sua importância para a cidade de Leopoldina/MG e sua vinculação histórica com um projeto de ensino mais abrangente para as artes.  Interessa-nos pensar como essa instituição de ensino foi se constituindo e ainda hoje se mantém como espaço de ensino e formação pela música, aproximando-nos da perspectiva de Michel Foucault, que investe na problematização da constituição de sujeitos permeados pelas relações de poder. Para o desenvolvimento da pesquisa, foi utilizada a metodologia de grupo focal com alunos em curso e egressos.
Isolamento de células-tronco de dentes decíduos exfoliados humanos e sua capacidade para diferenciação osteogênica
Authors: Zanette Rafaella de Souza Salomão , De Souza Gustavo Torres , De Souza Camila Maurmann , Maranduba Claudinéia Pereira , Rettore João Vitor Paes , Do Carmo Antônio Márcio Resende , Atalla Angelo , Silva Fernando de Sá , Santos Marcelo de Oliveira , Maranduba Carlos Magno da Costa
Published: November 2020

As células-tronco de dentes decíduos exfoliados, isoladas como uma subpopulação das células-tronco da polpa dentária, demonstram possuir a capacidade de se diferenciarem in vitro em neurônios, adipócitos, odontoblastos e osteoblastos. Devido a sua facilidade de obtenção, que não envolve um procedimento invasivo, esta linhagem celular é considerada uma grande promessa para a medicina regenerativa. Os objetivos deste trabalho foram estabelecer e caracterizar duas linhagens de células-tronco de dentes decíduos humanos. As linhagens foram isoladas a partir de amostras de crianças saudáveis de 6 anos de idade. Os resultados mostraram, por citometria de fluxo, que as células foram positivas para marcadores de células-tronco mesenquimais (CD105 (SH2), SH3 e SH4) e negativa para a marcação hematopoiética (CD45) e que as linhagens estabelecidaseram constituídas de uma população homogênea de células-tronco. As células obtidas foram avaliadas quanto a sua proliferação e capacidade de diferenciação osteogênica. As linhagens tiveram estatisticamente a mesma taxa de proliferação e foram capazes de diferenciação osteogênica.
Resiliência e Capacidade de Suporte do Parque Estadual do Ibitipoca (MG)
Authors: Barra Rocha Cézar Henrique , Do Vale Wesley Badoco , Castro Luiz Fernando de Paula , Paravidino José Martins , Da Silva Ana Luíza Fortes , Prado Tamires de Oliveira , Da Silveira Fábio Jacob
Published: November 2020

A pressão sobre áreas naturais tem aumentado devido ao modelo artificial disponível nas grandes cidades adensadas com concreto e asfalto e desprovidas de áreas verdes. O parque mais visitado de Minas Gerais é o Parque Estadual do Ibitipoca (PEIb), local ímpar e frágil por suas formações em quartzito e que precisa ser monitorado quanto aos impactos das visitações. Apesar da resiliência ao longo dos anos, é necessário medir a sua capacidade de suporte. Este trabalho apresenta a metodologia criada pelo NAGEA a partir da incorporação de novos elementos à Metodologia de Cifuentes (1992) com intuito de conseguir uma melhor adaptação à realidade brasileira. O novo método traz consigo a criação do fator de correção raízes expostas; alteração no fator acessibilidade através da classificação de rampas médias de 10% para 12%; acréscimo da vegetação lateral no fator de correção brilho solar; a conversão de ocorrências pontuais em lineares; e o uso da distância inclinada ao invés da horizontal. Em abril de 2019 no PEIb, foram monitorados os três roteiros disponíveis à visitação: Janela do Céu, Pico do Pião e Águas. Com o uso de receptores GNSS, as trilhas foram mapeadas e ocorrências como alagamentos, desgaste superficial do solo, raízes expostas e trechos com cobertura vegetal. Os dados foram processados, traçando a planta e o perfil longitudinal de cada trilha, determinando as rampas. Com a aplicação da metodologia, foi obtido os seguintes resultados:  959 visitantes diários em todo PEIb, sendo 152 no Circuito das Águas, 457 no Circuito Janela do Céu e 360 no Circuito Pico do Pião. Contudo, as metodologias de capacidade de suporte não são um fim em si, sendo apenas balizadora para estratégias mais abrangentes e integradas com o planejamento e o monitoramento de indicadores de impactos nas áreas protegidas.
On the influence of low silica content on phosphates glasses doped with Erbium Ions
Authors: Rúbio Sant'Anna das Dores Diogo , Rocha da Silva Victor , Silva Geraldo Henriques , De Oliveira Victor Hugo , Maria da Costa Ludwig Zélia , Valenzuela Bell Maria José , Ludwig Valdemir , Maigon Pontuschka Walter , Carvalho dos Anjos Virgílio
Published: November 2020

This work describes the spectroscopic characterization of a phosphate glass matrix doped with different Erbium concentrations. In order to increase the resistance of the glass, 3 mol %, of silicon oxide were added to the phosphate matrix. A study of the optical absorption, luminescence and lifetime was conducted in order to characterize the infrared emission of Er3+ ions at 1540 nm, due to the radiative transition 4I13/2 →4I15/2. Judd-Ofelt spectral analysis was carried out to determine the local structure and bonding in the vicinity of rare-earth ions. The experimental oscillator strengths calculated from the absorption spectra were used to evaluate the Judd-Ofelt intensity parameters Ωλ (λ = 2, 4 and 6). Changes in the glass density, refractive index and the values of Ω4 and Ω6 with different rare-earth concentrations are ascribed to changes in the glass network structure. Our results indicate that the present glass is a quite good matrix for Erbium ions, and the quantum efficiency of the 1540 nm emission was high. No quenching mechanisms were detected up to 2% of Erbium concentration.
La Alemania nazi y el fascismo español durante la Guerra Civil
Authors: Thomàs Joan Maria
Published: November 2020

El presente artículo reflexiona sobre las relaciones establecidas por la Alemania nazi durante la Guerra Civil española primero con el partido fascista español Falange Española de las JONS y posteriormente, desde el momento de su creación, con el partido único del régimen franquista, Falange Española Tradicionalista y de las JONS. Analiza los orígenes y desarrollo de dichas relaciones, centrándose en las de tipo político del Estado y del partido nazis establecidas por el Encargado de Negocios y después embajador general Faupel, caracterizadas por un extremado intervencionismo, así como las de su sucesor, el diplomático profesional von Stohrer, caracterizadas por una actitud más distanciada. El artículo incluye igualmente un análisis de las relaciones económicas, militares y policiales entre el régimen nazi y el Estado franquista durante la contienda.
PENGARUH NILAI PELANGGAN KUALITAS PELAYANAN TERHADAP KEPUTUSAN PEMILIHAN PENDIDIKAN KAMPUS BERBASIS VOKASI
Authors: Minggu Minggu , Rahmadhani May Vitha , Siswandi Siswandi
Published: November 2020

This research was conducted to determine how much the influence Customer Value to the College Selection Decision of Student  in Polytechnic LP3I Jakarta Kampus Blok M, to determine how much the influence Quality 0f Education Services to the  College Selection Decision of Student in Politectic LP3I Jakarta Kampus Blok M, and determine how much the influence Customer Value and Quality of Education services simultaneously to the College Selection Decision of Student  in Polytechnic LP3I Jakarta Kampus Blok M. This research was conducted on 75 students out of a population of 300 students using slovin method and quantitative research methods using regression analysis, to prove that the variable customer value has a positive and significant influence towards college selection decisions; and the variable quality of educational services has a positive and significant influence towards college selection decision. The research proved that the customer value has a positif influence 0,823 to the college selection decision,the quality of educational services has a positif influence 0,756 to the college selection decision,customer value and quality of education services simultaneosly has a significant influence 0,854. The Results of this research prove that hypotests Ha accepted and proven linear.

Keywords: College Selection Decision, Customer Value, Service Quality
Reflexions about the COVID-19 Pandemic
Authors: Soares Feitosa Gilson
Published: November 2020

The world has been surprisely caught by an unprecedent pandemic in the last 100 years. The editorial presents the  Bill Gates alerted about viral pandemics, as well as the problems faced of all over the world about lack of supplies and million of deaths because of the spreads of SAR-CoV-2 and the illness COVID-19. The editorial also approach the need of a better prepared to face an explosive appearance such as COVID-19 pandemic.
Immunologic Responses against SARS-CoV-2
Authors: Cássio Santana Meira  , Vinícius Pinto Costa Rocha  , Iasmim Diniz Orge  , Danielle Devequi Gomes Nunes  , Emanuelle de Souza Santos  , Gabriela Louise de Almeida Sampaio  , Patrícia Kauanna Fonseca Damasceno  , Afrânio Ferreira Evangelista  , Knop Luciana , Ricardo Ribeiro dos Santos  , Roberto Badaró  , Milena Botelho Pereira Soares
Published: November 2020

Coronavirus disease 2019 (COVID-19) emerged in Wuhan, China, in December 2019 and quickly spread worldwide becoming a global health problem unprecedented. The infection is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that is characterized as a RNA virus with an envelope derived from host cell with glycoprotein spikes, appearing like a crown-like external structure under electron microscope. Due to the aggressive spread profile of SARS-CoV-2, the scientific community is under pressure to generate knowledge about the morphology of the virus and the immune response against SARS-CoV-2, in order to generate useful information for the development of vaccines and methods of immunological diagnosis. Previous knowledge about other coronaviruses, such as SARS-CoV-1 and MERS-CoV, were the pillars for understanding the immune response of SARS-CoV-2. Until now, we know that the anti-SARS-CoV-2 immune response in the host involves mechanisms related to innate immunity, activation of CD4+ and CD8+ T cells and production of antibodies (IgA, IgG and IgM) against the virus. In spite of being a new pathogen, the literature on SARS-CoV-2 has increased dramatically in the past few months, especially in the immunology field. Here, we review the literature on SARS-CoV-2 immunology, focusing on the innate and adaptative immune responses.
Edirne, Tekirdağ, Kırklareli ve İstanbul İllerinde Atmosferik Engelleme ve Sıcak-Soğuk Hava Dalgaları İlişkisi
Authors: CANYILMAZ Mahiye Göksu , EFE Bahtiyar
Published: November 2020

Bu çalışma 2010-2019 yılları arasında; Edirne, Tekirdağ, Kırklareli ve Sarıyer-Kumköy-Kilyos istasyonlarında gözlenen sıcak-soğuk hava dalgaları ve atmosferik engelleme arasındaki ilişkiyi incelemek amacıyla yapılmıştır. Sıcak ve soğuk hava dalgalarının referans değerleri için her istasyondaki mevsimlik sıcaklık verilerinin 90. ve 10. persantil değerleri kullanılmıştır. Yapılan çalışmanın sonucu olarak; soğuk hava dalgalarının ilkbahar mevsiminde ortalama olay sayısı atmosferik engelleme gerçekleşen günlerde engelleme olmayan günlere göre en az %25 azalma olsa da, soğuk hava dalgalarının ortalama sürelerinin en az %13 arttığı tespit edilmiştir. Yaz mevsiminde ise atmosferik engellemenin olduğu günlerdeki soğuk hava dalgalarının ortalama olay sayısı, engelleme olmayan günlerde görülen ortalama olay sayısının en az 3,5 katıdır ve aynı zamanda yaşanan olayların ortalama sayısının da en ez %30 arttığı görülmüştür. Soğuk hava dalgaları ve atmosferik engelleme arasında çalışılan istasyonlarda kış mevsimi için genel bir yargıya ulaşılamamıştır fakat sonbahar mevsiminde genel olarak ortalama olay süresinin arttığı görülmektedir. Sıcak hava dalgaları için, kış mevsiminde engellemeli günlerdeki ortalama olay sayısı engelleme olmayan günlerdeki olay sayısının en az yarısına düştüğü görülmektedir. Buna rağmen olayların süresinde belirgin bir değişim görülmemektedir. Sıcak hava dalgası ve atmosferik engelleme olayları arasında bahar mevsimlerinde herhangi bir sonuca ulaşılamamıştır. Daha doğru ve anlamlı sonuçların elde edilmesi için 10 yıl değil, daha uzun süreli araştırmaların yapılması gerekmektedir.
Avis + Elsmere: A Collaborative Community Design Precedent
Authors:   University of Detroit Mercy, O'Leary Ceara , Heidgerken Tadd ,   University of Detroit Mercy
Published: November 2020

"Vibrant neighborhood spaces pave the way for more resilient and inclusive communities. This paper showcases a neighborhood space resulting from a collaborative, community-led design process that honors local knowledge and responds to contextual challenges. Avis + Elsmere, a project in Detroit, offers a model for collaborative practice as the product of a robust relationship between the client-collaborator – grassroots organization Inside Southwest Detroit – a diverse stakeholder group of neighbors and artists, the Detroit Collaborative Design Center (DCDC) at the University of Detroit Mercy (UDM), and the architecture office Et al. Collaborative"
DENSECITY: Innovation in Practice | A View from the City of Angels
Authors:   Brooks + Scarpa Architects, Inc., Brooks Angie
Published: November 2020

"How can architectural practice inform policy? How can design promote social change and heal those who have suffered through homelessness? How do city bureaucracies innovate and how can architects respond through their practice? The State of California, the City and the County of Los Angeles are requesting innovation from developers and architects through grants and proposal requests. Ballot measures are being passed to fund solutions; architects and developers can leverage this movement to innovate and create solutions for the future."
Bottom-Up, Top-Down, and the Messy Reality of the In-Between
Authors:   University of Washingto, Mohler Richard
Published: November 2020

"This paper reflects my recent five-year experience as a practicing architect, educator and advocate embedded in the contentious fray of public discourse regarding housing and land use policy in Seattle. During this period I testified before city council regarding proposed housing-focused land use legislation, presented my analysis of that policy in professional and community forums, published opinion pieces in the Seattle Times, coordinated the housing advocacy efforts of AIA Seattle, conducted graduate-level design studios focused on the topic at the University of Washington, and presented the student work (often with students) in venues throughout the city. I ended this period of local advocacy in 2018, when I was appointed to the Seattle Planning Commission, although I continue to help coordinate AIA Seattle’s advocacy efforts as co-chair of its Public Policy Board."
A pesquisa em linguagem e tecnologia no ensino de inglês no nordeste do Brasil
Authors: Aragão Rodrigo Camargo
Published: November 2020

Neste artigo, apresentamos o estado da arte de pesquisas em linguagem e tecnologias no ensino de inglês a partir do mapeamento da região Nordeste do Brasil de 2013 a 2017. O período escolhido é justificado pela comparação com os resultados de um mapeamento com recorte temporal anterior (PAIVA, 2013). O estudo se embasa em pesquisa de estado da arte (FERREIRA, 2002) e procedimentos de análise de conteúdo (DÖRNIEY, 2007). Buscou-se estabelecer unidades e temas significativos do corpus, inicialmente, no banco de teses e dissertações da CAPES, e posteriormente, nos portais eletrônicos dos programas de Pós-graduação em Letras e Linguística. Os resultados indicam continuidades nas práticas metodológicas, mas também tendências inovadoras. Destaca-se a presença de estudos que avaliam políticas públicas de tecnologias, a produção textual multimodal, bem como a continuidade de desafios enfrentados por professores de inglês no uso de tecnologias.
Para licenciandos em Matemática participantes do Programa Residência Pedagógica
Authors: Moreira Ana Paula , Passos Marinez Meneghello
Published: November 2020

Este artigo tem como objetivo investigar qual o significado de formação de professores para os integrantes do Programa de Residência Pedagógica do curso de licenciatura em Matemática de uma Universidade Tecnológica Federal do estado do Paraná. Para tanto, foram realizadas entrevistas semiestruturadas com os alunos participantes do projeto. Os depoimentos dos entrevistados foram analisados segundo os procedimentos indicados pela Análise de Conteúdo, tendo como categorias a priori os Focos da Aprendizagem Docente, os quais são: (i) interesse pela docência; (ii) conhecimento prático da docência; (iii) reflexão sobre a docência; (iv) comunidade docente; e, (v) identidade docente. Mediante esta investigação foram encontrados significados relacionados a progressos pessoais, estabelecimento de valores, vivências possibilitadas, reflexões deflagradas, questionamentos evidenciados, participações realizadas, aprendizados ocorridos, construções elaboradas, estratégias efetivadas, saberes e conhecimentos inerentes ao professor.
Pengaruh iklim komunikasi dan promosi jabatan terhadap kinerja dan motivasi dengan disiplin dan kepuasan kerja sebagai variabel intervening
Authors:   Program Studi Magister Manajemen, Universitas Bhayangkara Surabaya, Riski Sugeng , Erma Widiana Muslichah ,   Program Studi Magister Manajemen, Universitas Bhayangkara Surabaya
Published: November 2020

Purpose: Influence of communication climate and job promotion on employee performance and motivation with discipline and job satisfaction as intervening at PT. Japfa Comfeed Indonesia. Tbk in Gedangan Sidoarjo. The aim of this study is to test and analyze the influence of communication and promotion on employee motivation and performance with discipline and job satisfaction as variabels intervening at PT. Japfa Comfeed Indonesia. Tbk in Gedangan Sidoarjo Research methodology: The samples of this study are 74 respondents consisting of employees permanent of the division warehouse and production. This research applies path analysis by using the program of analysis Smart PLS. Results: The relationship between variables in this study produced thirteen hypotheses with significant influence and five hypotheses with not significant influence. Relation testing between organizational job promotion and motivation variabels has the biggest significance. Meanwhile, the relation testing between communication climate variabels and employee performance variabels has the smallest significance. Limitation: The limitation in this research is one company where the number of samples taken is only permanent employees of the warehouse and production only. Contribution: Results of this study are expected to be able to give contribution to human resources management and to practical management. Keywords: Communication climate, Job promotion, Employee Performance, Motivation, Discipline, Job satisfaction
Numerikus számítások hatékonyságának vizsgálata Python, Matlab és Octave programcsomagokkal
Authors: Gyulai Márk
Published: November 2020

A numerikus analízis a matematikai problémák közelítő, számítógéppel is hatékonyan elvégezhető megoldásával foglalkozik. A cikkben bemutatott kutatás célja, hogy összehasonlítja a Python NumPy és SciPy, a Matlab és GNU Octave programcsomagok alapvető numerikus algoritmusainak sebességét. A bemutatásra kerülő sebességtesztek olyan alapvető numerikus műveletekre koncentrálnak, mint a mátrix műveletek, interpolációk, lineáris egyenletrendszer megoldása, valamint a numerikus integrálás és deriválás. Különböző méretű tesztfeladatok esetén, az egyes műveletek elvégzéséhez szükséges időket fogjuk összevetni, valamint a mérés során figyelembe vesszük az egyes implementációk közötti különbségeket is.
Hordozható kovácsműhely tervezése
Authors: Varga Balázs , Takács Ágnes
Published: November 2020

A kovácsolás napjainkban egyre jobban visszatérni látszó foglalkozás, mely az információ és az oktató anyagok nagy száma és könnyű hozzáférhetősége miatt ma már nem csak teljes értékű szakmának, de kedvelt hobbitevékenységnek is számít. Elsősorban a hobbikovácsok körében született meg az igény egy olyan szerkezetre, mely egybefoglalja a kovácsoláshoz szükséges alapvető eszközöket, oly módon, hogy ezek együttesen, helytakarékosan, valamint minél egyszerűbben mozgathatók, szállíthatók legyenek. A cikk egy hordozható kovácsműhely vázának néhány tervezési kérdésével foglalkozik.