bluuebunny/crossref_metadata_2025 huggingface dataset:
The Importance of E-Learning in the Teaching Processor Secondary Schools /Review Article
Authors: Jacksi Karwan , Sulaiman Maryam Ameen , Saeed Rezgar Hasan
Published: February 2021

This study explores the usefulness of e-learning in teaching in secondary institutions. The topic of using new information and communication technology for teaching and learning is very relevant in secondary education institutions. Henceforth, Students can manage the most recent Technologies better. In addition, the School must play an important role to give instructional classes to the teacher to build up their aptitudes on the utilization of present-day advancements and to encourage downloading E-educational module from the service's site. However, still there are deterrents with the application: First, right off the bat the substance of the educational programs is not perfect with E-learning. Second, shortcoming of the mechanical framework important for the foundation of the E-learning framework in general optional school. Third, low attention to understudies and educators about the significance of E-learning and absence of sufficient capability for chiefs and instructors where instructors experience issues in tolerating this kind of Education. This paper examines the concept and the description of e-learning as presented by different researchers, the role that e-learning plays in secondary education institutions in relation to teaching and learning processes, and the advantages and disadvantages of adopting and implementing it.
دور التسويق عبر وسائل التواصل الأجتماعي (Facebook) في تنمية وعي المستهلك دراسة أستطلاعية لآراء عدد من مستهلكي السلع المعمرة في مدينة دهوك.
Authors: Fouad Faris M.
Published: February 2021

هدفت هذه البحث إلى تحديد دور التسويق عبر وسائل التواصل الأجتماعي الـ(Facebook) في تنمية وعي المستهلك منطلقاً من أنموذج فرضي يأخذ بعين الاعتبار طبيعة العلاقة بين تحديد التسويق عبر وسائل التواصل الأجتماعي (Facebook) وتنمية وعي المستهلك، وتم بناء فرضيتين أساسيتين تنبثق منها مجموعة من الفرضيات الفرعية.

وتحقيقاً لهدف البحث واستكمالاً لمتطلباتها أعدّ الباحث إطاراً نظرياً مستفيداً من أدبيات الموضوع، وتكـون مجتمـع البحث مـن مستهلكي السلع المعمرة من مستخدمي موقع (Facebook) في مدينة دهوك. وتم أختيار عينة من مجتمع البحث تمثلت ( 230 ) فرداً .

وجرى تطوير استبانه لجمع بيانات الجانب الميداني وقد قام الباحث بتفريغ البيانات الخاصة باستمارة الاستبيان على الحاسبة الإلكترونية مستخدما البرمجة الإحصائية الجاهزة للعلوم الاجتماعية SPSS-20، وبتوظيف بعض الأساليب الإحصائية تم تحليل النتائج واختبار الفرضيات على الحاسبة، مما نتج عنه مجموعة من النتائج الإحصائية تمكّن الباحث من توظيفها في بناء استنتاجات دراسته وكان في مقدمتها أن المبحوثين وبنسبة جيدة استخدموا صفحة (Facebook) من أجل الإطلاع على المنتجات بدل الذهاب إلى الأسواق التقليدية، ويستنتج الباحث في ضوء ذلك بان استخدام صفحة التواصل الاجتماعي (Facebook) من قبل العينة المبحوثة موجود بما يخص السلع المعمرة لانها تحتاج الى قرار يشترك به اكثر من شخص من الجماعات المرجعية. كما خرجت البحث بعدد من المقترحات من اهمها ضرورة تشجيع التسوق عبر مواقع التواصل الاجتماعي وخاصة عبر (Facebook) لانه يوفر حلول لهذه المشكلة حيث يمكن تخصيص حملات تسويقية و اعلانية تستهدف فئة معينة من الجمهور بناءاً على اهتمامات المستهلكين واحتياجاتهم الشخصية لتحقيق عائد أفضل للمسوق والمسوقين على حد سواء في مجال السلع المعمرة.

الكلمات المفتاحية: التسويق من خلالـ مواقع التواصل الأجتماعي، تنمية وعي المستهلك
COVID-19 Outbreak
Authors: ISA Khairunesa , RAZAK Nor Asiah
Published: February 2021

Coronavirus (COVID-19) outbreak has been declared as a global health disruption, and at the same time affecting the global economy. As the phenomena are unprecedented, there is a lack of studies on the impact of COVID-19 on businesses, especially in Malaysia. For preventing the virus transmission to the plethora of people, the Malaysian government declared Movement Control Order (MCO) on 18 March 2020 in which the citizens are ordered to practice‘social distancing’ to avoid further outbreak of COVID-19 . Therefore, the study aims to identify the impact of COVID-19 transmission on SME businesses in Malaysia.This study employed an online survey system using a self-administered questionnaire that was distributed all over the country through social media. Findings indicated that the spreading of of COVID-19 in Malaysia has significant impacts on SME business, which affected almost 87% of business owners in the study. Only 13% of business owners in this study are not affected as they have an online business. The findings reveal that 76% are affected by the COVID-19 outbreak as they need to shut down their business during MCO. The remaining of the respondents are still operating their business as they are of the 'food and beverage' sector
Nursing Activities Score como ferramenta para avaliar a carga do trabalho de enfermagem
Authors: Cabral João Victor Batista , Silveira Maria Mariana Barros de Melo , Silva Adrielle Nunes de Andrade , Xavier Amanda Tavares
Published: February 2021

Objetivo: Descrever o uso do Nursing Activities Score (NAS) como ferramenta para avaliar a carga de trabalho de enfermagem em unidades de terapia intensiva. Métodos: Trata-se de uma revisão integrativa realizada com publicações de 2010 a 2018 nas bases de dados da Biblioteca Virtual em Saúde (BVS). Os descritores utilizados para a pesquisa foram "Unidade de Terapia Intensiva", "Taxa de Trabalho" e "Enfermagem". Resultados: Foram encontrados 18 estudos que descreveram a utilização do NAS. A maioria utilizou o método descritivo-exploratório, com nível de evidência no estrato 2 de Oxford, publicados em 2014 e oriundos do sudeste do Brasil. O NAS ainda é pouco utilizado nas UTIs brasileiras e, através de novas pesquisas, espera-se que sua implementação aumente em instituições públicas e privadas, investindo no aumento de pessoal e com o benefício de novas tecnologias. Considerações finais: Destacamos que o NAS ainda é pouco utilizado nas UTIs brasileiras, todavia constitui-se como um instrumento importante para mensurar a carga de trabalho de enfermagem na UTI, pois contempla diversas atividades realizadas e demostrou, de modo geral, que o tempo dispensado pela enfermagem é elevado, indicando sobrecarga da equipe o que pode associar-se à ocorrência de eventos adversos e de uma assistência menos efetiva.
Caregivers of schizophrenic patients in Calabar: Extent and predictors of burden
Authors: Okafor Chidi John , Emedoh Thomas
Published: February 2021

Objectives:

Caregivers of people with mental disorders usually experience consequences which might generate burden and have an effect on each aspect of their life. This study aimed to assess the extent and associated factors of burden on caregivers of schizophrenic patients seen at the Federal Psychiatric Hospital Calabar, Nigeria.

Material and Methods:

A hospital-based cross-sectional study design was used to study 100 consecutive caregivers of patients with schizophrenia seen at the outpatient clinic of the hospital between 15 December 2019 and 21 April 2020. Data were collected from the study participants using socio-demographic questionnaire, Patient Health Questionnaire-9, Brief Psychiatric Rating Scale (BPRS), and Family Burden Interview Schedule. Quantitative data were presented as mean (standard deviation) and categorical data as frequency/percentages. Statistical analysis was performed using independent sample t-test. Multivariate analysis was performed to determine the predictors of burden on caregivers. All values of P < 0.05 were considered significant.

Results:

Ninety percent and 88% of the caregivers, respectively, had some level of objective and subjective burden. The factors associated with objective burden on the caregivers were employment status of the patient, BPRS score, number of suicide attempts, and number of hours per week the caregiver was in contact with the patient. The subjective burden was associated with BPRS score, number of hospitalization, number of relapses, monthly income of the caregiver, and caregiver’s level of education. The employment status of the patient significantly predicted objective burden on the caregiver (P < 0.001).

Conclusion:

This study showed that caregivers of patients with schizophrenia experience high level of burden. The study also identified factors which might guide clinicians to institute intervention programs aimed toward reducing burden on the caregivers of schizophrenic patients.
Depression and suicidal ideation among HIV seropositive patients attending the special treatment clinic of the University of Calabar Teaching Hospital, Calabar, Nigeria
Authors: Bisong Elvis Mbu , Okafor Chidi John , Ayuk Agam Ebaji , Asibong Udeme Essien , Okpa Henry Ohem
Published: February 2021

Objectives:

The introduction of highly active antiretroviral therapy and innovations in healthcare has contributed in improving the lives of persons living with human immunodeficiency virus (HIV)/AID. Patients infected with HIV are more susceptible to develop psychiatric illnesses. Depression is common among patients suffering from chronic illness such as HIV/AIDS and can exacerbate these illnesses. Depression has been observed to be twice as common in HIV seropositive individuals than in the general population. Undiagnosed and untreated depression in patients suffering from HIV/AIDS could lead to poor adherence to medications and lower quality of life. Depression is associated with rapid HIV disease progression. The diagnosis of HIV infection may be associated with feelings of anger, denial, sadness, guilt feelings, loss of self-esteem among others. These negative feelings could lead to suicidal ideation and attempted suicide or suicide. We sought to determine the prevalence rates, sociodemographics and predictors, of depression and suicidal ideation among study participants.

Material and methods:

Two hundred and two adult participants who met the inclusion criteria were recruited into the study. Mini International Neuropsychiatric Interview English version 6.0.0 was employed to diagnose depression and suicidal ideation. Data were analyzed using Statistical Package for the Social Sciences version 20.0. Significant levels were set at P < 0.05.

Results:

This study revealed prevalence rates of 11.4% for depression and 7.9% for suicidal ideation among study participants. Majority of the participants were females in the young age group category of 30–40 years (45%) with mostly secondary education (47.8%), most had a higher CD4 count greater than 200 cells/µL (82.6%) and were mainly on zidovudine/lamivudine/nevirapine combination therapy (56.5%). Mean age, CD4 count, and viral load levels were lower in HIV patients with depression but were not statistically significant (P > 0.05). CD4 count and viral load were not significantly associated with suicidal ideation. Lower age (30–40 years) was significantly associated with suicidal ideation (P < 0.05). Suicidal ideation is a predictor of depression in the same way depression is a predictor of suicidal ideation (P < 0.05).

Conclusion:

Routine screening for depression and suicidal ideation especially among younger HIV/AIDS patients is recommended in the clinic setting.
ANALYSIS OF DEVELOPMENT OF DEPLETED OIL DEPOSITS IN WESTERN KAZAKHSTAN, INCREASING THEIR FINAL OIL RECOVERY
Authors:   Satbayev University, Moldabayeva Gulnaz , Suleimenova Raikhan ,   Satbayev University, Tuzelbayeva Sholpan ,   Satbayev University, Tabilov Mukhammed ,   Satbayev University, Pak Leonid ,   Satbayev University
Published: February 2021

This article discusses topical issues, further effective development of depleted oil deposits (INZ) is to increase their final oil recovery on the example of the Kenkiyak field, considering the control and regulation of field development.
MODELING INNOVATIVE YOUTH ENTREPRENEURSHIP: THE EXPERIENCE OF BELARUS
Authors:   Georgi Rakovski Military Academy (Sofia, Bulgaria), Terziev Venelin Krastev , Klimuk Vladimir ,   Baranavichy State University (Baranavicy, Belarus)
Published: February 2021

The model of a modern society is a „digital society” based on the widespread use of information and communication technologies. Information is of utmost importance. However, „unprocessed“, „unprepared“ information is not valuable, but quite the opposite – it causes great damage economic, technical, psychological, political and others). First of all, this concerns young people, who are exposed to the influence of „harmful factors“ (information messages, appeals) more than other categories of the population.
INFORMATION SUPPORT DEVELOPMENT FOR CASH FLOW MANAGEMENT IN TERMS OF ACCOUNTING AND ANALYTICS
Authors:   Kremenchuk Mykhailo Ostrohradskyi National University, Didur Serhii , Tsyhan Raisa ,   Kremenchuk Mykhailo Ostrohradskyi National University, Bondarenko Irina ,   Kremenchuk Mykhailo Ostrohradskyi National University
Published: February 2021

The article is devoted to the study of the essence of cash flows and their accounting and analytical support. The urgency of solving issues of information support for cash flow management is substantiated, taking into account the current conditions of economic development and factors influencing the movement of cash resources. Using previous work, the authors of the article proposed their vision for the definition of «cash flows» as a set of all types of cash assets that serve the enterprise, are transformed and ensure its continuous operation. Classification is improved taking into account modern business conditions on the basis of non-cash. Accounting and analytical support for the formation of information in the cash flow management system is developed, which has a separate accounting and analytical component. The necessity of carrying out the administrative analysis of cash flows of the enterprise on the basis of a technique based on implementation of analytical procedures of the relevant information and acceptance of the corresponding administrative decisions is proved. According to the authors, accounting and analytical support of cash flows is a system that is based on financial and management accounting data as an informative basis for their analysis, is part of the overall process of managing the activities of the enterprise. The proposed system of accountingиand analytical support is focused on solving problems of cash flow management and control, which are the subject of interest of opportunistic managers. When developing forms of management reporting and methods of analysis, the tasks to be solved should take into account the interests of the owners. Further research is proposed to develop a methodological approach to management analysis of cash flows and search for key indicators to assess the level of efficiency of generating cash resources of the enterprise to avoid agency conflicts.
Privatización de funciones inherentemente estatales
Authors: Piombo Horacio J.J.
Published: February 2021

Interbranch delegation of powers has been an issue of deep and recurrent analysis in our field; particularly, the exercise of legislative powers by the Executive branch. Conversely, the delega-tion of inherently governmental functions to private parties has received less attention. This essay tries to determine what should be understood by such, and consequently, if the transfer of certain quintessential state matters to private hands is tolerated by our legal system –and if so, under what circumstances– in light of the non-delegation doctrine, due process of law and the democratic form of government.
New Validated RP-HPLC Method for Cisplatin and Topotecan in API and Vaccine Form and its Stress Studies
Authors: Subrahmanyam Talari  , Anuradha V  , Komala sai prathyusha A
Published: February 2021

We have developed a completely unique and reliable HPLC technique for simultaneous quantification of Cisplatin and Topotecan. A chromatographic detachment was attained on a XDB C18 column (150x4.6mm, 3.5 µ) using isocratic elution with a buffer containing buffer and acetonitrile with the proportion of 60:40 as a movable phase with a flow of 1 mL/min at room temperature and UV detection was carried out at 262 nm. Dissolve 1mL of triethylamine in 1 lt of HPLC grade water and filter through 0.45 µ filter paper. This solution was used as a buffer. 10 min run time was used to separate Cisplatin and Topotecan. The analysis was achieved within 15 min over honest linearity within the concentration range from 5-75 µg/mL of Cisplatin and 2-30 µg/mL of Topotecan. By injecting the standard six times, system suitability parameters were studied and the outcomes were under the acceptable limit. Precision and recovery study results were found to be within a suitable limit. By using the above technique, the assay of the marketed formulation was performed and found to be within the limit. Degradation studies were carried out on Cisplatin and Topotecan, with a purity threshold greater than the purity angle in all conditions and within the acceptable range. The above-mentioned technique was validated according to ICH guidelines.
NRAS is unique among RAS proteins in requiring ICMT for trafficking to the plasma membrane
Authors: Ahearn Ian M , Court Helen R , Siddiqui Farid , Abankwa Daniel , Philips Mark R
Published: February 2021

Isoprenylcysteine carboxyl methyltransferase (ICMT) is the third of three enzymes that sequentially modify the C-terminus of CaaX proteins, including RAS. Although all four RAS proteins are substrates for ICMT, each traffics to membranes differently by virtue of their hypervariable regions that are differentially palmitoylated. We found that among RAS proteins, NRAS was unique in requiring ICMT for delivery to the PM, a consequence of having only a single palmitoylation site as its secondary affinity module. Although not absolutely required for palmitoylation, acylation was diminished in the absence of ICMT. Photoactivation and FRAP of GFP-NRAS revealed increase flux at the Golgi, independent of palmitoylation, in the absence of ICMT. Association of NRAS with the prenyl-protein chaperone PDE6δ also required ICMT and promoted anterograde trafficking from the Golgi. We conclude that carboxyl methylation of NRAS is required for efficient palmitoylation, PDE6δ binding, and homeostatic flux through the Golgi, processes that direct delivery to the plasma membrane.
OUTFLOW OF RUSSIAN CAPITAL ABROAD
Authors: Shumilina Vera , Leonova Mariya
Published: February 2021

In the context of globalization, the level of capital mobility and the introduction of financial markets has sharply increased, which has led to a large outflow of resources from the country. Therefore, such a process at any time was and remains one of the most important and relevant.
POVERTY PROBLEMS IN RUSSIA
Authors: Sidorina Tat'yana , Yusupova Elena
Published: February 2021

The article is devoted to the study of the state, assessment and possible directions of poverty reduction, as one of the most important social problems that poses a threat to the security of the Russian Federation
Investment activity in an unstable market situation
Authors: Krohicheva Galina , Lermontova Aleksandra , Kurilov Andrey
Published: February 2021

The article discusses such concepts, investments, stock exchanges, their varieties, tasks and sources. Ways to earn money-using investments are described. The comparative characteristics of direct investments of the Russian Federation by institutional sectors of the economy in comparison of 2020 with 2019 are carried out. The influence of investment portfolio selection on profitability is considered.
Economic sanctions as an instrument of pressure on the Russian economy
Authors: Sidorina Tat'yana , Sitnikova Liana
Published: February 2021

Russia's desire to assert its position in a multipolar world in the context of the current process of globalization of world economic relations against the background of political and economic instability makes the problem of sanctions very urgent. This article presents the essence, types, positive trends and negative consequences of economic sanctions and countermeasures for the Russian economy.
Open Innovation in Times of Covid-19: The case of Project OxyGEN
Authors:   University of Girona, Burbano Giovanna Lara
Published: February 2021

In the face of the health crisis unleashed by Covid-19, experts worldwide took on the challenge of designing a low-cost emergency ventilator that could be assembled quickly. This study analizes the successful case of the Project OxyGEN, led by the Barcelona-based design firm Protofy, which created an industrial-class emergency ventilator and obtained approval from the Spanish Ministry of Health (AEMPS) for use on patients. The project received scientific support from a local Research Hospital, and SEAT, a Volkswagen subsidiary, collaborated in the OxyGEN ventilators’ mass-production. This open-hardware project sprung into action teams in more than 32 countries involved in the collaborative design process, adopted or made an iteration of the technology. These teams collaborated with suppliers, consultants, universities, and research institutes to drive this innovation forward. The case highlights the Open Innovation approach, inter-organisational relationships between firms of different sectors with research institutions, and innovation communities.
The Role of Awareness, Learning and Knowledge in Entrepreneurial and Firm Leadership Processes
Authors:   Universitat Internacional de Catalunya, Vila Neus
Published: February 2021

Scholars in recent years have urged researchers to shift from their traditional focus on specific characteristics of entrepreneurs and leaders toward research on entrepreneurship and leadership processes. To do this, researchers must better understand entrepreneurs and leaders’ cognitive processes involved in learning, awareness and knowledge acquisition. In this paper systems thinking theory and system dynamics methodologies are used in the development of a dynamic conceptual framework of learning effectiveness. The research applies the conceptual framework to nine U.S. wineries and identifies the consequences of varying levels of awareness and types of knowledge, as well as alternative learning processes on entrepreneurship and leadership effectiveness. Results indicate that one’s level of awareness and knowledge are key factors in enhancing one’s ability to learn. The types of awareness and knowledge identified most critical for enhancing entrepreneurship and leadership effectiveness are: (a) awareness of one’s mental models and learning patterns, (b) systemic knowledge and (c) business related knowledge. Results also identify that there is a positive relationship between the level of entrepreneurs’ intangible key resources and the scope of the learning process undergone. The higher the level of the intangible resources the entrepreneur moves from conducting single loop learning to double loop learning.
The Effectiveness of Audio-Visual Health Education Media on Diet on The Level of Knowledge and Attitude of Adolescent in the Prevention of Type 2 Diabetes Mellitus
Authors: Mansyah Barto , Rahmawati Fetty
Published: February 2021

Efforts to increase knowledge and attitudes in adolescents require a learning media that can not only be used in the world of education but also in the health sector, especially in the prevention of DM where one of the risk factors for DM is an unhealthy diet. One of the media that can be used is audio visual. This study aims to analyze the effect of audio-visual media on diet on the level of knowledge and attitudes of adolescents in preventing type 2 diabetes. This type of research is a quasi-experimental study with a pretest-posttest with control group design. The results showed that there were significant differences in the mean value of knowledge (p value 0,039 <0,005) and attitude score (p value 0,001 <0,005) which were significant between the intervention group and the control group. The mean increase in the knowledge value of the intervention group was 16,27 higher than the control group was 9,20. In the attitude variable, the mean score of attitudes in the intervention group was 13,27 higher than the mean value in the control group, namely 9,20, so it can be concluded that the intervention group in the form of audio-visual health education showed better results in increasing knowledge and attitudes about diet in the prevention of type 2 diabetes.
Better Quality of Sleep among Adolescents by Considering the Intensity of Social Media Utilization
Authors: Habibah Siti , Winahyu Karina Megasari , Wreksagung Hyang , Hastuti Hera , Kartini Kartini
Published: February 2021

The basic human needs, such as sleep quality, often take for granted that low sleep quality among adolescents could affect various health problems. One of the factors correlated with sleep quality in adolescents is the use of social media. This study aimed to identify the association between social media utilization and sleep quality among adolescents. The study used a descriptive correlation with a cross-sectional design. The Social Networking Time Use Scale and Pittsburgh Sleep Quality Index questionnaires were used based upon validity and reliability test. A Cross-sectional study was used with a convenience sampling frame by recruiting 188 adolescents. The analysis technique used was Chi-Square. The results showed that respondents with a high intensity of social media users who have good sleep quality were 29 (15, 4%) respondents, and those who have low sleep quality were 66 (35.1%) respondents. It revealed a significant association between the intensity of social media use and sleep quality in adolescents (X2 = 27,564a,  df = 1, p< 0,05). It suggests that adolescents should reduce the intensity of social media use to improve their sleep quality.
Interest in Learning of Indonesian Students with Online Gaming Addiction In The Academic Learning Process
Authors: Fahrizal Yanuar , Faiga Nurul
Published: February 2021

Student interest in learning has been declining due to the increasing number of distractions. Interest is one of the important factors contributing to one’s desire and motivation to satisfy curiosity. As the times evolve, many things affect student interest in learning; one of which is smartphones equipped with the internet that promotes the ease of performing activities. Smartphones and the internet offer online games that can be accessed by anyone to play at any time, which can trigger online gaming addiction. The study aims to examine the interest in learning of nursing students who are addicted to online games. This study employed a qualitative method with a phenomenological approach. Data were collected through interviews, observations and documentation. The participants of the study were five students recruited using a snowball sampling method. Data were analyzed using Giorgi method. Results showed that interest in learning of students with online gaming addiction in the academic learning process varies. This can be seen through three emerging themes: student gaming behaviour, changes in students after online gaming, and the learning process of students with addiction to online games. It can be concluded that students’ online game behaviour is influenced by impulsivity that changes student behaviour and leads to addiction.
Interprofessional Collaboration and Burnout Nurses in Hospital
Authors: Imallah Rosiana Nur , Kurniasih Yuni
Published: February 2021

The demand safe for nursing sarvices, effective nursing services, excellent service, high standard of clinical services, causes nurses to be in a state of prolonged stress. The prolonged stress experienced by nurses will result in burnout which will directly impact the quality of care and quality of nursing services performed. if this is allowed to continue it will have an impact on the future of the hospital. This study aimed to know the relationship between interprofessional collaboration with the incidence of burnout in the hospital. This study used a correlational design with a cross-sectional approach to time. The population in this study were nurses in IGD, ICU, and ICCU. Interprofessional collaboration had no relationship with nurse burnout (p> 0.05). The results of the analysis showed that nurses experienced burnout because it was influenced by other factors such as work environment, workload and work stress. Further analysis from the researcher shows that good interprofessional collaboration is needed in improving the performance of nurses but it is not the only factor that can affect nurses experiencing burnout.
Factors Affecting The Quality Of People With HIV / AIDS (PLWHA) Undergoing ARV Therapy
Authors: Pratiwi Iva Gamar Dian , Yasin Zakiyah
Published: February 2021

The incidence of HIV / AIDS is still high and is still described as an iceberg phenomenon. This condition forces PLWHA to always feel worried about their lives because they are threatened with death. The problems of PLWHA in Sumenep Regency are very complex, starting from the quality of life, stigma against PLWHA, transmission, treatment, to PLWHA, which until now have not been detected, coupled with the cultural atmosphere of the Madurese community, especially Sumenep Regency. This study aims to determine the factors that affect the quality of life of PLWHA undergoing ARV therapy. This type of research uses a survey design and is a quantitative study. The study population was all PLHIV patients who were actively using ARV therapy in Sumenep Regency, with a total sample of 56 respondents. Purposive sampling is used as a sampling technique. The independent variables in this study were socio-demographic factors (marital status, gender, age, education, occupation), medication adherence, duration of ARV therapy and stigma. The dependent variable is the quality of life. Chi-square test was used to test bivariate analysis and path analysis with the help of AMOS software was used to test multivariate analysis. The research location is in Sumenep Regency, namely in four Puskesmas which are used as ARV drinking facilities. In this study, it was found that the variable data that had the most influence on the quality of life was gender with a Nilai p of 0.055 which was smaller than α (0.1). The cross-tabulation analysis showed that female ODHA respondents had at least a good quality of life, namely only 14.3%. This is not surprising if this happens in Sumenep Regency, because from a cultural perspective, the Madurese are still very thick with their culture and local wisdom, where women are still in a subordinative position. Women with HIV / AIDS will be stigmatized and excluded from society.
PERSONAL SA LES IN THE INTEGRATED COMMUNICATIONS SYSTEM: TRADITIONS AND MODERNITY
Authors:   Moscow Polytechnic University, Shevchenko D.A.
Published: February 2021

Personal sales are seen in the context of the integrated communications of which they are a part. The author reveals the essence and features of personal sales in comparison with other elements of communication, such as: advertising, public relations, direct marketing. The article attempts to 1 Эволюция email-маркетинга: от QWERTYUIOP до GDPR. URL: https://habr.com/ru/ company/mailru/blog/447730 2 Профессии будущего: новые и перспективные. URL: https://hh.ru/article/14969 33 МАРКЕТИНГ И ИННОВАЦИИ consider the traditions that have developed in the scientific literature on this type of communication. The author considers the specifics of personal sales strategies in the communication system of B2C and B2B market sectors. The problems of the use of telephone marketing, the development of electronic marketing, in particular, the importance and prospects of the development of e-mail as a form of personal communication are touched upon. A special place is given to the characteristic of the activities of specialists in the field of personal sales using Internet technologies. The role of the site, content strategy, methodology for assessing the site of Professor D. Shevchenko, social networks. Modern trends and tendencies in the development of the profession of personal sales specialists are considered.
CREATIVE INDUSTRIES AS THE ENGINE OF THE ECONOMY OF THE XXI CENTURY
Authors:   Financial University under the Government of the Russian Federation, Korenkov A.O.
Published: February 2021

The article examines the definition of creative industries and emphasizes that this sector of the economy remains blurred. However, despite a number of existing problems and peculiarities of functioning, creative industries remain one of the key resources for innovative development of territories. The formation of creative clusters is considered as a factor of active growth, and attention is paid to the contribution of creative industries to GDP and GRP.
ASSESSMENT OF THE IMPLEMENTATION OF THE STATE PROGRAM “PROVIDING AFFORDABLE AND COMFORTABLE HOUSING AND UTILITIES TO CITIZENS OF THE RUSSIAN FEDERATION”
Authors:   RANHiGS, Ivankina E.V. , Polyakov F.А. ,   RANHiGS
Published: February 2021

Currently, in the Russian Federation, economic development largely depends on the implementation of national projects and government programs adopted by the president and government. The federal executive bodies are developing specific goals and objectives of strategic planning affecting almost all areas of the economy, as well as a set of various measures with established indicators for the timing of their implementation and the resources necessary for their implementation. State programs are divided into 5 areas, each of which is responsible for a specific area. The state program “Providing affordable and comfortable housing and utilities for citizens of the Russian Federation” is part of a major area of “New Quality of Life” under which projects are being implemented in the field of social policy and construction. This article presents an assessment of the goals and objectives set in the state program “Providing affordable and comfortable housing and utilities for citizens of the Russian Federation”, analyzes the results of achieving the goals, considers examples of foreign practices and techniques in this area, and presents possible actions to reduce risks failure to achieve program targets.
PORTFOLIO AS A TOOL FOR EVALUATING INTELLECTUAL CAPITAL
Authors:   MIREA – Russian Technological University, Nadtochiy Yu.B. , Gurova M.E. ,   MIREA – Russian technological University
Published: February 2021

The competitiveness of an organization (including an educational organization) is determined by a combination of various factors, including: the presence of highly qualified personnel in its staff, the implementation of research activities, the use and implementation of innovations, and others. The real pace of life and scientific and technical development has its own requirements for employees of organizations – it is necessary to be a highly qualified specialist. And one of the tasks of the employer is the task of finding such a specialist. A well-designed electronic portfolio, which is considered one of the tools for assessing the intellectual capital of an employee or future specialist (student), can help in this.
A Brief Discussion on Chinese Medicine Behaviour and Prescription Compatibility
Authors: Toa Steven Loh Cheng , Xin Yi Goh
Published: February 2021

Chinese medicine (CM) is gaining popularity in recent years, prompting researchers’ and clinicians’ interest and effort into the makings and effects of it, especially after the announcement of World Health Organisation’s incorporation of CM into the mainstream medical compendium, followed by the promising outcome brought about by the implementation of CM in the recent pandemic. Individual herb has complex properties, coming from its pharmacological properties and the Chinese medical principles of organ-directed, taste and dynamic orientational behaviours. The use of individual herb in CM prescription is rare. Formula prescriptions predominantly consist of two ingredients or more. To fully reveal the effects of CM is a great challenge. The compound reaction of various herbs, the absorption and utility rate by the body, uniqueness of individual physique, sub-types of pathological behaviours and time-line progression at the healing process add on to the complexity of understanding the full effect of CM. Various theories such as pathophysiology guidance, pharmacokinetic-pharmacodynamic compatibility method, and Global Systems Biology for Integrative Genomics, Proteomics and Metabolomics, which interactively provide a more comprehensive and greater in-depth understanding, together with the consideration of development timeline, may shed more light to revealing the full picture of the effects of compatibility prescription.
Cold urticaria with risk of anaphylaxis treated with omalizumab: a case report
Authors: Bedolla-Pulido Tonatiuh Ramses , Mariscal-Castro Juan , González-Mendoza Tania , Morales-Romero Jaime , Bedolla-Barajas Martín
Published: February 2021

Background: Omalizumab, a monoclonal anti-IgE antibody has recently been used as an option in the treatment of inducible urticaria.Case report: We describe the case of a 46-year-old woman, referred at Department of Allergy and Immunology, Hospital Civil de Guadalajara Dr. Juan I. Menchaca by a history of hives, body itching, changes in skin color following exposure to water and chest tightness after consumption of cold beverages; therefore, she limited outdoor activities and personal hygiene. We conducted challenges tests with heat, soaked towel, treadmill and dermographism which were negative, the ice cube test was positive; to establish the speed of hive formation, we establish exposure to cold intervals for 1, 3, 5 and 10 min; a positive result was obtained since the third minute. Because of the poor response to drug treatment, cold avoidance measures, poor quality of life, high risk of anaphylaxis and the advent of the winter season, omalizumab was administered at doses of 150 mg monthly during the winter season. After the first dose, episodes of hives in areas exposed to cold were not reported; the ice cube test before the second dose and in the months that followed was negative; the patient was able to ingest cold beverages and food. There were no adverse reactions attributable to the use of omalizumab. Three year after the first dose, the patient remains asymptomatic. Conclusion: We reported one of the first cases of cold induced urticaria with risk of anaphylaxis with a positive response to omalizumab, which was reflected in symptom control and improved quality of life.
Eficacia y seguridad de la inmunoterapia subcutánea para alérgenos inhalables en pacientes con alergia respiratoria a un año de tratamiento
Authors: Sánchez-Villalobos Johav Yael , Caballero-López Chrystopherson , López-García Aída Inés , Rivero-Yeverino Daniela , Arana-Muñoz Oswaldo , Papaqui-Tapia José Sergio , Ríos-López Juan Jesús , Payán-Diaz Jonathan Higgins , López-Romero Carlos David , Villada-Villada Erika
Published: February 2021

Antecedentes: La inmunoterapia específica con alérgenos es una importante modalidad terapéutica para el manejo de la rinitis y asma alérgica.
Objetivo: Evaluar la eficacia y seguridad de la inmunoterapia subcutánea con alérgenos en pacientes con alergia respiratoria del Hospital Universitario de Puebla posterior a 12 meses de tratamiento.
Métodos: Estudio longitudinal, secuencial, analítico, cuasiexperimental, prolectivo. Durante 12 meses se incluyeron pacientes con asma o rinitis, sensibilizados a aeroalérgenos, de cuatro a 65 años y de ambos sexos; bimensualmente se recolectaron los cuestionarios CARAT y Portnoy para evaluar la eficacia y seguridad, respectivamente.
Resultados: Se incluyeron 47 pacientes, 37 (78.7 %) mujeres. La edad promedio fue de 29.8 años. El 76.6 % tuvo diagnóstico de rinitis alérgica y 23.4 % de asma y rinitis alérgica. Al comparar el promedio del CARAT inicial contra el promedio final mediante prueba de t de Student se obtuvo un valor de –8.86 y p < 0.05. Se reportó una frecuencia total de reacciones adversas locales de 19 % y de reacciones adversas sistémicas de 2.1 % a los seis y 12 meses del tratamiento.
Conclusiones: El esquema de inmunoterapia evaluado, derivado de la Guía Mexicana de Práctica Clínica de Inmunoterapia 2011, es eficaz con un conveniente perfil de seguridad.
Alteraciones inflamatorias clínicas y moleculares en enfermedad granulomatosa crónica
Authors: León-Lara Ximena , Rodríguez-D’Cid Roberto , Rioja-Valencia Ricardo , Ayala-Alvirde Alexandra , Aliaga-Taipe Ida Lizbeth , Espinosa-Padilla Sara , Blancas-Galicia Lizbeth
Published: February 2021

La enfermedad granulomatosa crónica (EGC) es un error innato de la inmunidad. Se caracteriza por deficiencia en la función del complejo de la NADPH oxidasa. La EGC ha sido una oportunidad para estudiar la función de las especies reactivas de oxígeno (ROS) en el sistema inmune innato. La ausencia de ROS producidas por la NADPH oxidasa en los neutrófilos y en los macrófagos lleva a mayor susceptibilidad a infecciones bacterianas y fúngicas, debido a que las ROS participan en la eliminación de los microorganismos. Las manifestaciones inflamatorias y autoinmunes también están presentes en la EGC, sin embargo, no es del todo clara la relación de causalidad entre la falta de ROS y los síntomas inflamatorios. Se han realizado diversos ensayos in vitro en humanos y experimentales en ratones para tratar de entender esta relación. Los estudios muestran que las ROS reaccionan con diferentes moléculas del sistema inmune, inhibiendo o estimulando su función, lo que explica que en la EGC se afecten varias vías de la inflamación que no están relacionadas entre sí; por lo tanto, han sido diversos los mecanismos de afectación descritos, como por ejemplo una mayor producción de citocinas proinflamatorias, un incremento en los linfocitos TH17 y una alteración en procesos como eferocitosis, apoptosis, autofagia e inflamasoma. El entendimiento de los mecanismos que llevan a la inflamación en la deficiencia del complejo de la NADPH oxidasa ha llevado a plantear nuevos tratamientos que actúan en procesos como la autofagia, el inflamosoma o el bloqueo de citocinas proinflamatorias. En esta revisión describimos las diferentes manifestaciones inflamatorias en EGC y los mecanismos moleculares a través de los cuales la falta de ROS conduce a la hiperinflamación.
Epidemiología del asma en adultos. Una visión introspectiva
Authors: Parisi Claudio Alberto Salvador , Zunino Sergio , Las Heras Marcos , Orazi Laura , Bustamante Lucrecia , Juszkiewicz Estefania , Svetliza Graciela , Ritchie Carla , Antonietti Carolina
Published: February 2021

Antecedentes: El asma es una enfermedad crónica de gran impacto en la salud pública y en la calidad de vida de los pacientes. En Latinoamérica existen escasos estudios epidemiológicosObjetivo: Describir la prevalencia del asma y las características clínico-demográficas en una población adulta de un sistema de salud privado de la ciudad de Buenos Aires.Métodos: Estudio de corte transversal de adultos afiliados al programa médico de un sistema de salud privado de Buenos Aires, entre el 1 de enero de 2017 y 1 de enero de 2018, con diagnóstico médico de asma. Resultados: La prevalencia de asma en pacientes adultos de un sistema de salud prepago en la ciudad de Buenos Aires fue de 6 % (n = 66, IC 95 % = 5-7) y de asma grave de 5 % (n = 3 IC 95 % = 1-13) La mayoría de los pacientes presentaron asma intermitente y leve. Conclusión: El estudio aporta nuevos datos sobre la epidemiología del asma en la región.
La neurología de COVID-19
Authors: Cuevas-García Carlos , Calderón-Vallejo Alejandra , Berrón-Ruiz Laura
Published: February 2021

Las manifestaciones clínicas de COVID-19 recuerdan las del síndrome de insuficiencia respiratoria aguda inducido por el síndrome de liberación de citocinas y la linfohistiocitosis hemofagocitica observada en pacientes con otros coronavirus como SARS-CoV y MERS-CoV. Los neurólogos tienen el reto de evaluar pacientes con enfermedades neurológicas preexistentes que contraen SARS-CoV-2, pacientes con COVID-19 que presentan emergencias neurológicas y pacientes portadores del virus que desarrollan complicaciones neurológicas secundarias, durante el curso de la enfermedad o posterior a la misma. Algunos autores y reportes en la literatura recientes sugieren que las manifestaciones neurológicas en pacientes portadores de SARS-CoV-2 pueden asociarse con mayor gravedad de la enfermedad.
RESEPSI JAMA’AH MASJID AL-AWWAB DESA PUNDUNG SLEMAN TERHADAP SHALAWAT NGELIK
Authors: Abidsyah Jumaida Aulia
Published: February 2021

Shalawat Ngelik is a recitation of blessings using the rhythm of Javanese style accompanied by high-pitched voice or high intonation. This tradition existed in the village of Pundung, Sleman for approximately 50 years. In this article, the discussion was the reception or response of the people of the village of Pundung, Sleman, especially the jama’ah of AlAwwab mosque to the existence of Shalawat Ngelik. This research was a qualitative research with data collection techniques combining field research and library research. Analysis of the reception of the Jama'ah Masjid Al-Awwab in the village of Pundung, Sleman on the Shalawat Ngelik using reception typology categorized by Ahmad Rafiq, namely exegesis receptions, aesthetic receptions, and functional receptions. The indication of exegesis reception is seen in Kyai Nur Iman's understanding of Q.S. al-Ahzab [33]: 56. It is the basis idea of Shalawat Ngelik. Meanwhile, the aesthetic receptions can be seen in the recitation of Shalawat which is done by Ngelik, which is using Javanese style rhythms with a shrill voice or high intonation. It should be noted that the recitation of the Shalawat Ngelik using Javanese verse still refers to the Shalawat Barzanji. Finally, the functional reception is indicated by the influence on the attitudes and behavior of the Jama'ah Masjid Al-Awwab, Pundung, Sleman village. Among them, getting closer to Allah Swt, love more and make Rasulullah SAW as a role model, and by reading Shalawat Ngelik his heart becomes peaceful.
TEMA-TEMA KAJIAN AL-QUR’AN DI BARAT PERSPEKTIF FAZLUR RAHMAN (1919-1988)
Authors: Anshori Muhammad
Published: February 2021

Western scholars have written on various themes or topics on the Qur'an so that the number of works or literature on this issue is very large. One of the Muslim scholars who carried out a mapping of the theme of al-Qur'an studies in the West was Fazlur Rahman (1919-1988). He was one of the Muslim scholars who had studied and taught in the West, so that his scientific authority was recognized by many circles. This paper aimed to analyze the typology or specific themes of al-Qur'an research in the context of literature developing in the Western world in general, especially before and during Rahman's time. Using historical analysis methods and literature criticism, Rahman mapped all literature related to the study of the Koran in the West into three main themes. First, literature or works attempted to prove that the Qur'an had been influenced by Judeo-Christian teachings. Second, literary literature examined the chronological arrangement of verses and surahs of the Koran. Third, literatures studied the Koran in general or certain topics. The discourse of the study of the Qur'an in the West cannot be separated from these three themes.
Elterliche Täterschaft im Spiegel von Akten, Dokumenten und Recherchen von Patienten
Authors: von der Stein Bertram
Published: February 2021

Der Autor weist darauf hin, wie wichtig die Wertung der von Patienten mitgebrachten Dokumente und Akten als Beweisstücke für ihre Schädigung durch elterliches Verschulden ist.
»Time is on my side«
Authors: Peters Meinolf
Published: February 2021

Die Ereignisse 1968 jährten sich 2018 zum 50sten Mal. Im folgenden Beitrag wird diese Zeit kurz skizziert und auf kontroverse Einschätzungen sowie politische und soziokulturelle Folgen eingegangen. Es lässt sich zeigen, dass sich Folgen dieser Zeit des Aufbruchs in unterschiedlichen Facetten bis heute nachweisen lassen, allerdings nur, wenn man sich von dem zum Mythos geronnenen Etikett »68« löst und die gesamte Entwicklung der 1960er Jahre betrachtet. Schließlich werden einige Überlegungen im Hinblick auf die Folgen dieser generationenspezifischen Erfahrungen im Alter angestellt.