bluuebunny/crossref_metadata_2025 huggingface dataset:
Les candidats aux élections présidentielles dans les discours de presse française et kazakhe
Authors: Prmanova Elmira
Published: February 2022

Cet article propose d’analyser et comparer les différents enjeux de la construction de l’image d’un chef d’État dans les régimes présidentiels de deux contextes sociopolitiques différents — la France et le Kazakhstan. Ces deux terrains ont les mêmes institutions démocratiques et le même fonctionnement politique, mais pas la même durée d’existence, ni les mêmes processus de construction des discours sociaux. Pour mener précisément cette comparaison, nous proposons ici d’observer la construction de l’image de candidats à la présidentielle dans le discours de presse (en 2012 pour la France et en 2011 pour le Kazakhstan). La construction de l’image des candidats est analysée à partir de deux angles. Tout d’abord la construction des « deux corps » : le corps politique (candidat à la présidentielle ou représentant d’une fonction politique) et le corps physique (traits de caractère, comportement, habitudes, famille et entourage proche, état physique, de santé). Ensuite, la construction de l’ethos du candidat (l’image construite par le candidat lui-même), ainsi que de l’ethos médiatique des candidats (l’image du candidat construite par les médias). L’analyse comparative se décompose en trois strates : la comparaison de l’image des candidats au sein d’un même journal, la comparaison entre deux journaux du même pays, et comparaison entre les discours de presse des deux pays.
Changing the Biological Sex in Spain: Advantages and Disadvantages of the New Legislation
Authors: Trofimets I. A.
Published: February 2022

The article is devoted to the peculiarities of the legal procedure for change of gender in Spain. Changing the biological sex of a person has become a common legal practice in some countries. However, the legislative solution is different. In Spain, the following approach is used: gender transformation is based on the social identity of the individual and is possible without therapeutic or surgical intervention. Currently, the judicial procedure for confirming the change of biological sex by a person remains in place, but the issue of amending the current legislation and introducing administrative regulations for this legal fact with attribution to the jurisdiction of civil registration authorities is being considered.
Potential of regenerative medicine for treatment of vitiligo patients
Authors: Kubanova A. A. , Volnukhin V. A. , Proshutinskaya D. V. , Zhilova M. B. , Chikin V. V. , Karamova A. E. , Saitburkhanov R. R.
Published: February 2022

The article presents a review of publishes sources on the efficacy of methods such as tissue engineering and cellular transplantation of autologous melanocytes for treatment of vitiligo patients. The article describes general principles of treatment and particular features of current melanocyte transplantation methods.
Systemic treatment of seborrheic dermatitis with retinol palmitate
Authors: Kalinina O. V. , Albanova V. I. , Belousova T. A. , Nozdrin V. I.
Published: February 2022

The goal of the study. Evaluating of the effectiveness of treatment of men with a diagnosis «Seborrheic dermatitis of the scalp» by the system using of retinol palmitate. Material and methods. 36 patients every day for 2 months received overnight per os 200000 ME of retinol palmitate, and in the comparison group (39 people) antiseborrheic shampoos have been used. The dynamics of severity of skin oiliness, pruritis, erythema, peeling, infiltration, excoriations has been evaluated in points. Before and after the treatment a histological and morphometric study of biopsy material from the affected areas has been carried.The terms of relapses have been set. Results. Retinol palmitate treatment efficiency - 91.7%, antiseborrheic shampoos - 84.6%. Along with the regression of symptoms of the disease in both groups after retinol palmitate treatment significantly declined oiliness of skin; the sizes of sebaceous glands acini and the presence of differentiated sebocytes, the squares of lymphocytic-macrophage clusters in the dermis, the number of keratinocytes with vacuolated cytoplasm have been reduced. Relapses of the disease during a year occured more rare - in 21 patients out of 32 (in the comparison group- in 25 out of 31) and at a later date (in the first 3 months in 2 patients out of 32, in comparison group in 10 out of 31). Identified effects were due to the action of retinol palmitate on the morphogenesis of the sebaceous glands.
NEW APPROACH IN URTICARIA TREATMENT
Authors: Samtsov A. V.
Published: February 2022

The article presents the European Guidelines for the Diagnostics and Management of Urticaria (revised in 2013) and new data on the physiopathology of urticaria related to the role of the platelet-activating factor (PAF) activating mast cells, attracting eosinophils and neutrophils, improving vascular permeability (it is more potent than histamine by 1,000 times) and mucosal edema, and increasing the level of pro-inflammatory cytokines. The data promoted the creation of a new rupatadine molecule, which blocks histamine and PAF receptors at the same time improving the therapeutic effect during urticaria treatment as compared to other antihistamine drugs. The author presents the study results confirming the efficacy and safety of rupatadine.
Role of peptide growth factors in the rhythm of change hair
Authors: Kubanov A. A. , Gallyamova YU. A. , Selezneva O. A.
Published: February 2022

The article presents current data on the role growth factors play in hair physiology. Based on a review of literature, the authors described the role growth factors play for initiating, suppressing the growth and differentiating hair follicles. According to them, each morphologic development stage of hair follicles is characterized by its own factor expression pattern. Referring to experimental and clinical studies, the authors describe the role some growth factors play for mechanisms promoting the development of androgynous and focal alopecia.
Dermatology development in russia and the ussr (1950-1959)
Authors: Belova-Rakhimova L. V. , Prokhorenkov V. I. , Guzei LN. .
Published: February 2022

History of dermatology development in Russia and the USSR in 1950-1959. words: dermatological service in Russia and USSR in 1950-1959.
Sex and age as biological determinants of autoimmune skin diseases
Authors: Nikolaeva T. V. , Voronina L. G. , Setko N. P.
Published: February 2022

Goal. To study and analyze the relationship of autoimmune diseases of the skin to sex and age. Materials and methods. Study of the relationship of autoimmune of skin diseases to sex and age was performed using contingency table analysis methods, which included the implementation of Pearson x2 to test the hypothesis of independence of the two nominal attributes, calculation of standardized residual values, mapping the relevant category attributes using the method of correspondence analysis, calculation of coefficients of communication Pearson, Chuprova and Kramer. Differences were recognized to be statistically significant at the observed level of significance p < 0,05. In the analysis of standardized residuals were established the following conditions: if the absolute value of the standardized residuals ≥ 2, it was considered that the differences between the observed and expected frequencies are statistically significant at the 0,05 level, if standardized residue ≥ 2,6 the differences are significant at 0,01, if the residue standardized ≥ 3,3 the differences are significant at the 0,001 level. Results. Autoimmune skin diseases linked to sex and age of patients. Vitiligo is associated with male sex, localized scleroderma with women. Sex as a biological factor does not affect the appearance of alopecia areata, lupus erythematosus and bullous dermatosis. Age has in general a greater influence on the formation of autoimmune dermatoses. Alopecia areata is associated in the age period 0-14 and 30-44 years, vitiligo with age period 18-29 years, bullous dermatosis linked to the age group 60 years and older. Conclusion. Sex and age have a differential impact on the formation of autoimmune dermatoses, as biological risk factors of their formation.
Clinical features and differential diagnostics of segmental vitiligo and nevus achromicus with children
Authors: Proshutinskaia D. V.
Published: February 2022

Clinical presentation is given of eruption in the case of segmental vitiligo and nevus achromicus. Literary data was presented, issues of differential diagnostics were discussed.
A case of generalized pustular psoriasis
Authors: Oklopkov V. A. , Pravdina O. V. , Chermoschentsev A. A. , Repina T. V. , Poleshuk E. I. , Gudoshnik V. G. , Gorodilov R. V.
Published: February 2022

The article presents a clinical case of generalized pustular psoriasis. Complex therapy features for this rare and severe type of psoriasis are described.
The role of antihistamines in chronic actinic dermatitis treatment
Authors: Orlov E. V. , Konnov P. E.
Published: February 2022

Inveterate actinic dermatitis is an immunologically mediated photodermatosis characterized by itchy eczematous dermhelminthiasis exposed to sunlight. The disease proceeds in the same way as the atopic eczema or atopic dermatitis. The treatment of patients with inveterate actinic dermatitis is similar to the treatment of patients with atopic dermatitis and eczema. Administration of the modern antihistaminic preparation desloratadine (Aerius) in the treatment has a positive effect on the skin process relief and on some cellular and humoral immunity factors.
Topical antibiotics for acne treatment
Authors: Silina L. V. , Pismennaya E. V. , Kolbina M. S.
Published: February 2022

Urgency. Acne is a prevalent polymorphous multifactorial inflammatory disease with various clinical forms ranging from the mildest ones (comedonal) to the most severe forms such as phlegmonous, indurative and cystic acne. According to epidemiology studies, the acne incidence rate in general population varies from 85% to 93%; moreover, there is a trend towards the growth in the incidence rate of postpubertal and persistent acne in adults. Acne treatment methods depend on the adequate clinical assessment of the disease severity, character of eruptions, skin type, any concomitant pathologies and patient’s age. Topical therapy is administered to all patients regardless of the disease severity and forms a mandatory part of the therapeutic complex treatment of acne patients. Despite the range of available drugs and treatment methods, researchers keep searching for new drugs and treatment methods for treating acne. Combination acne therapies enjoy keen interest in the world for reasons such as stable treatment results and improved compliance. It is essential that the administration of a combination therapy came along with drugs having a complimentary mechanism of action. Drug combinations have an effect on a large number of pathogenetic factors resulting in acne (excessive follicular hyperkeratosis, propagation of P. аспвв, inflammation). Goal. The goal of this article is a review of literature sources on current aspects of acne topical therapy and examining results of studies of a combination therapy, azelaic acid and clindamycin. Study materials and methods. The project was carried out at the GBOU VPO Kursk State Medical University, Ministry of Health of the Russian Federation. Major results. Both Russian and foreign authors use combination therapies with topical administration of azelaic acid and clindamycin on a broad scale. According to a study conducted in Russia, azelaic acid is a good combination substance for administration with both topical antibiotics (the antibiotic is to be applied to pustules once a day) and adapalene. According to the clinical study results, 15% azelaic acid (Azelic gel) as a part of a combination topical therapy reduces adverse effects observed in the course of a monotherapy with topical retinoids and improves the therapeutic efficacy when combined with antibacterial drugs. Conclusion. The practical experience and different variants of a combination therapy with 15% azelaic acid (Azelic gel) and 1% clindamycin gel (Clindovit) provide dermatologists with an opportunity to treat acne in different groups of patients on an everyday basis with increased efficacy achieving a longer remission of the inflammatory process.
Prospects of the practical use of nanoparticles in dermatology
Authors: Kubanova A. A. , Utz S. R. , Kubanov A. A. , Persati M. A. , Svenskaya YU. I.
Published: February 2022

The review presents data from foreign literature sources on the problem of using nanoparticles for theranostics of skin diseases. The article examines properties and operating principles of nanomaterials used most frequently for drug encapsulation and emphasizes advantages of such systems for the treatment of different dermatoses. The need in further exploration of this subject due to underinvestigated adverse events caused by nanoparticles is discussed.
Up-to-date laboratory methods for assessing the safety of perfumery and cosmetic products in the quality assurance system of the Russian Federation
Authors: Rezaykina A. V. , Petrova N. P. , Rotanov S. V.
Published: February 2022

Most of the developed countries as well as Russian Federation have a dynamically developing quality assurance system for testing the quality of laboratory tests and safety of perfumery and cosmetic products entering the market comprising a regulatory and legal framework, physical infrastructure and appropriate methodical basis and staff. At the same time, it is necessary to develop alternative test methods adjusted to perfumery and cosmetic products on a regular basis. In addition, it is necessary to optimize methods for ensuring standard sample preparation conditions in response to new forms of cosmetic products when determining microbiological, physical, chemical and toxicological characteristics, and more accurate observation methods for clinical and laboratory indices to be approved by supervising authorities.
Dermatovenereologic healthcare delivery in Russian Federation. Incidence of sexually transmitted infections and skin disorders, 2013-2015
Authors: Kubanova A. A. , Kubanov A. A. , Melekhina L. E. , Bogdanova E. V.
Published: February 2022

The paper presents the analysis of the work and resources of dermatovenereologic healthcare organizations in Russian Federation, the results of hospital and day hospital beds restructurisation, medical service density, hospital bed usage, incidence of sexually transmitted infections and skin disorders in Russian Federation in 2013-2015.
The role of bacterial infection in the pathogenesis of psoriasis
Authors: Slesarenko N. A. , Utz S. R.
Published: February 2022

The article presents the results of numerous studies confirming the involvement of bacterial agents in the psoriatic process manifestation as triggering factors. The article discusses potential pathogenic mechanisms of the participation of bacterial superantigens in the initiation of a cascade of immunological reactions resulting in the hyperproliferation of keratinocytes. The expediency of using antibacterial agents as a part of a complex therapy of different forms of the disease is discussed.
Anti-cytokine therapy of a patient suffering from psoriatic arthritis
Authors: Onipchenko V. V. , Sergeeva I. G. , Krinitsyina Yu. M. , Kondrashova A. A. , Pahomova V. V. , Hismatulina N. V.
Published: February 2022

The article presents a clinical case study of an efficient therapy with infliximab used for a 33-year-old patient with a severe course of psoriasis, psoriatic arthritis, psoriatic onychopathy; chronic hepatitis C with the minimum activity, replication phase; hyper- and normatrophic scars affecting 40% of the body surface; cicatricial contractures; complicated posterior polar cataract of both eyes; secondary amyloidosis of the kidneys with a nephrotic syndrome. It also demonstrates the significance of the anti-cytokine therapy as a method of choice in a complicated clinical situation.
Topical treatment of atopic dermatitis in children: current challenges and answers
Authors: Namazova-Baranova L. S. , Murashkin N. N. , Materikin A. I. , Ambarchyan E. T. , Epishev R. V.
Published: February 2022

Atopic dermatitis (AD) is the most prevalent skin disease in the early childhood and is a considerable problem both for patients and members of their families and for the society on the whole. In most cases, AD requires a long-term therapy such as the use of anti-inflammatory drugs. Selective inhibitors of the synthesis and release of proinflammatory cytokines - topical calcineurin inhibitors (Tcis) - are now used to solve this problem, with pimecrolimus being one of them. Pimecrolimus has been thoroughly examined for the past decade in different clinical studies involving a total of over 4,000 infants (below 2 years of age). These studies demonstrated the efficacy and safety of pimecrolimus for AD in children provided it is used in a long-term therapy on an intermittent basis. Unlike topical corticosteroids, the long-term use of pimecrolimus is not associated with any risk of development of systemic immunosuppression, skin atrophy, skin barrier dysfunction or systemic absorption so it is safe even if applied to the most sensitive skin areas. In view of this, the authors make a conclusion that pimecrolimus used in the form of a cream is a safe and efficient drug for the treatment of infants aged over three months suffering from atopic dermatitis.
Experience destructive therapy anogenital warts
Authors: Rahmatulina M. R. , Nechaeva I. A. , Shalva Mardi
Published: February 2022

Objective. To assess the efficiency and tolerability of the Mardil Zinc Max, solution for external application, in topical therapy of patients with anogenital warts. Materials and methods. The study involved 58 women and 12 men at the age of 18 to 57 years old, suffering from anogenital warts. the diagnosis was confirmed by identification of human papillomavirus by the polymerase chain reaction in real time. All the patients were treated by the chemical destruction of anogenital warts with the 1.5% solution of zinc chloropropionate in 50% 2-chloropropionic acid (Mardil Zinc Max) by a single application of the solution on the pathological eruptions. The results of treatment were assessed in 2 weeks, in 1, 3, 6 and 9 months after the destructive therapy. Results. In 2 weeks 62 (88.6%) patients showed a clinical cure with complete tissue regeneration in the lesions, in 8 (11,4%) cases in areas of the preparation erosions were visualized in the epithelialization phase, and they completely resolved within 1 week. recurrences of anogenital warts were detected in 1 (1,4%) patient in the observation period up to 3 months and in 2 (2,8%) patients during 9 months after carrying out the destruction. Adverse drug events have not been identified in the course of therapy and follow-up. Conclusions. As a result of the treatment of anogenital warts with the Mardil Zinc Max high rate of performance and security was set (100%), as well as the low percentage (4,2%) of development of relapses.
MILKER’S NODULE. A PERPLEXING FARMYARD INFECTION AND THREAT TO THE IMMUNOCOMPROMISED
Authors: Rubins Andris , Rubins Silvestrs , Handler Nancy S. , Janniger Camila K. , Schwartz Robert A. , Septe Marcis
Published: February 2022

Milker’s nodules, also called paravaccinia, is a DNA virus transmitted from infected cows to humans. It results from contact with cattle, cattle byproducts, or fomites. Classified as an occupational disorder, those at risk of exposure include farmers, butchers, and agricultural tourists. The viral infection begins 5—15 days after inoculation as an erythematous-purple, round nodule with a clear depressed center, and a surrounding erythematous ring. While familiar to those in farming communities, the presence of the nodule may be concerning to others, particularly the immunosuppressed. Milker’s nodules are selflimited in immunocompetent individuals and heal without scarring within 8 weeks. Another member of the Parapoxvirus genus, the orf virus, is also transmitted from animals to humans by direct-contact. While complications are rare, hematopoietic stem cell transplant recipients are at risk of graft-versus-host disease, as the parapoxvirus may trigger these complications in immunocompromised individuals. In addition, paravaccinia may serve as the antigen source for the development of erythema multiforme. The unique structure and replication process of viruses in the Poxvirus family, while includes the Parapoxvirus genus, have been a focus for treatment of infections and cancer. Manipulation of these viruses has demonstrated promising therapeutic possibilities as vectors for vaccines and oncologic therapy.
ACRODERMATITIS CONTINUA SUPPURATIVA HALLOPEAU IN COMBINATION WITH LOCALIZED PSORIASIS VULGARIS
Authors: Sokolovskiy E. V. , Mikheev G. N. ,  Gordeeva A. A.
Published: February 2022

А clinical case of a rare form of pustular psoriasis, known as “acrodermatitis continua suppurativa Hallopeau” is described. The involvement of the distal phalanges of the fingers and toes in combination with localized psoriasis vulgaris is observed. Specific features of this case are the presence of two different forms of the disease and comorbidities, that limits treatment options. The article provides current data on the clinical features and management of acrodermamtitis continua suppurativa Hallopeau. An acceptable personalized treatment with systemic retinoids and topical substances containing betamethasone dipropionate and calcipotriol has been proposed.
EXPERIENCE OF REMOVING BENIGN NEOPLASMS OF SKIN IN CERVICOFACIAL AREA USING THE METHOD OF PLASMA ABLATION
Authors: Ritina I. F. , Rubins S. A. , Rubins A. Y.
Published: February 2022

Choosing appropriate methods for removal of benign skin lesions (BSL) in the cervicofacial area has always been an important and challenging issue. Removal of the BSL is indicated and performed for medical and aesthetic reasons. A method with less painful procedures, a short healing period, without noticeable long-lasting traces (such as scars, dyschromia) and, predictably, fewer repeat procedures is preferred. Objectives. Evaluation of the effectiveness, safety and convenience of BSL plasma ablation using Plexr® (GMV, Italy); Comparison of the reparative processes speed after the BSL removal in the cervicofacial area applying the Plexr® device with other instrumental methods (based on literature reviews). Materials and Methods. We identified a group of patients wishing to remove papilloma, xanthelasma, dermal nevi, dermatofibroma on their face and body. Neoplasms (skin lesions) were assessed visually and by means of the Dermlite 3DN dermatoscope. Patients with atypical skin lesions were excluded from the study and referred to a medical oncologist for consultation. Each patient, having been fully briefed on the nature and course of the medical procedure, as well as required aftercare, submitted their written informed consent. Plasma ablation of BSL was performed using Plexr® device. Re-examination of patients was carried out after the scab from the treated area of the skin had fallen off. Results. We have performed 373 BSL removal procedures, including 212 (57%) — in the cervicalfacial area, among which there have been 47 (13%) cases of acrochordoni, papilloma, xanthelasma, syringoma and upper and lower eyelid milia removals. Complete healing has been recorded in 98% of all cases, with repeated corrective procedure being required only for one patient due to insufficiently deep tissues destruction in the course of multiple syringoma removal in the lower eyelid area. Conclusion. The results obtained allow to consider the method of BSL tissues plasma ablation applying Plexr® device effective, safe, non-traumatic, inexpensive, with a short period of tissue healing (7—10 days). BSL removal with the help of Plexr® — is a good alternative to conventional surgical and laser methods, which can be introduced into medical practice.
Psoriatic arthritis: particular features of its clinical course
Authors: Martynov A A , Znamenskaya L F , Butareva M M , Kappusheva I A , Popov D V , Martynov A A , Znamenskaya L F , Butareva M M , Kappusheva I A , Popov D V
Published: February 2022

The number of patients suffering from severe forms of psoriatic arthritis has increased for the recent years. Psoriatic
arthritis is accompanied by synovitis and exudation in the joint cavity in some patients. Healing depends on the timely and
correct treatment
Clinical features of neurosyphilis in sex partners
Authors: Kolokolov O V , Bakulev A L , Sholomov I I , Kravchenya S S , Popovicheva O A , Kolokolov O V , Bakulev A L , Sholomov I I , Kravchenya S S , Popovicheva O A
Published: February 2022

There was a study involving 726 patients with different syphilis forms with the aim of revealing a neurological deficiency
in them. Nervous system affection symptoms were founding 298 of them. Neurosyphilis was diagnosed in 165 patients
based on the conducted examination. There were five neurosyphilis cases in sex partners among them. The article
provides a detailed description of the clinical picture of the disease and discloses the laboratory examination results.
The polymorphism of clinical and laboratory manifestations of the syphilitic infection in sex partners can be explained by
different terms of infestation, particulars of the immunity and presence of concomitant neurologic and somatic diseases.
Markers of efficacy of Infliximab in psoriasis patients
Authors: Kubanova A A , Znamenskaya L F , Frigo N V , Volkov I A , Rotanov S V , Rezaykina A V , KUBANOVA A A , ZNAMENSKAYA L F , FRIGO N V , VOLKOV I A , ROTANOV S V , REZAIKINA A V
Published: February 2022

The article presents the results of molecular and genetic studies aimed at determination of molecular markers for forecasting
the clinical response of psoriasis patients to treatment with Infliximab. The authors revealed that it is possible to forecast
high efficacy of treatment with Infliximab in case TT genotype is revealed at the 676 locus of exon 6 of the TNF-RII gene and
IL-10 is present in the blood serum prior to the onset of treatment in the amount of more than 2.7 pg/ml.
Treatment of patients suffering from psoriasis in cases of resistance to Infliximab
Authors: Butareva M M , Znamenskaya L F , Martynov A A , BUTAREVA M M , ZNAMENSKAYA L F , MARTYNOV A A
Published: February 2022

The authors describe cases from the clinical practice of efficient use of preformed physical factors, general PUVA
baths, in treatment of psoriasis patients who have previously received treatment with Infliximab, an anti-cytokine drug
(Remicade).
Treatment of acne in women ovarian hyperandrogenism and insulin resistance
Authors: Golousenko I Yu , Perlamutrov Yu N
Published: February 2022

Objective. To determine the efficacy of Glucophage, a biguanide manufactured by MERCK SANTE s.a.s) (France), in the treatment of women with acne, ovarian hyperandrogenism and insulin resistance. Materials and methods. The study involved 65 women aged 20—40, who were administered Glucophage (a biguanide) for a year. The dynamical analysis of acne components and mean values of the acne dermatology index was performed, the therapeutic effect was assessed, and the subjects underwent gynecological and anthropometric examinations as well as laboratory tests: blood hormone level; urine steroid profile; metabolic status; cholesterol, triglycerides and blood biochemistry test as well as ultrasonic examination of small pelvis organs and sebometry. Results. The treatment reduced the acne dermatology index by 89.12%; the therapeutic effect was achieved in 84.62% of the patients; the treatment also produced a positive effect on anthropometric characteristics and resulted in the normalization of the hormonal status, urine steroid profile indices as well as lipid and carbohydrate metabolism, and moderate suppression of the skin fat secretion. Conclusion. The treatment of women suffering from acne, ovarian hyperandrogenism and insulin resistance with Glucophage normalized carbohydrate metabolism, hormonal status and urine steroid profile, which resulted in a positive therapeutic effect on acne.
A case of Kaposi’s sarcoma: using immunohistochemistry studies to identify human herpes virus of the 8th type
Authors: RUKSHA T G , AKSENENKO M B , KHORZHEVSKY V A , BEKAZUROV S S
Published: February 2022

The article discusses problems related to optimizing differential diagnostics of Kaposi’s sarcoma using the immunohistochemistry analysis, in particular, identification of human herpes virus of the 8th type being the causative agent of the development of the disease.
Information value of treponema-specific class M antibodies for syphilis diagnostics
Authors: Rotanov S V , Ermatova F A
Published: February 2022

The authors conducted a comparative study of 474 blood samples collected from patients suffering from different clinical forms of syphilis and 152 healthy subjects using four present-day laboratory methods intended to reveal anti T. pallidum antibodies (EIA IgG+IgM+IgA, EIA IgM , IF abs (IgG) and IF abs-IgM). The study results helped assess the information value of the new medical technologies based on State Standard GOST R 53022.3-2008: EIA IgM and IF abs-IgM as applied to diagnostics of clinical forms of syphilis. For early syphilis diagnostics, it is recommended to determine specific IgМ to T.pallidum in EIA IgM and IF abs-IgM characterized by high clinical sensitivity (97.26% and 95.89% for primary syphilis; 93.50 and 89.50% for secondary syphilis, respectively) and specificity (98.37% and 86.30%, respectively). It is not recommended to use EIA IgM and IF abs-IgM for latent forms of syphilis due to low clinical sensitivity of these tests (16.67-61.61% and 26.09-53.93%, respectively).
Study of the genetic factors predisposing to the development of psoriasis
Authors: MINEEVA A A , KOZHUSHNAYA O S , VOLNUKHIN V A , FRIGO N V , ZNAMENSKAYA L F , KUBANOV A A , MELEKHINA L E
Published: February 2022

Background papers on psoriasis epidemiology, pathogenesis and genetics are presented. Special attention is given to genetic factors of the aptitude to psoriasis development. Were analysed researches, dedicated to the genome-wide screening of associations of polymorphic genetic locus with psoriasis development. Obtained results allow to reveal pathogenic psoriasis mechanisms, to forecast the character of the clinical course of the disease, as well as the efficiency of therapy and forecast the risk of psoriasis origination at patient’s relatives.
Analysis of risk factors and modern clinical and laboratory peculiarities of non-aggravated and aggravated forms of the urogenital chlamydial infection in men
Authors: RAHMATULINA M R , POPOV D V , NECHAEVA I A , PLAHOVA K I
Published: February 2022

The authors present the results of studies of risk factors at the contamination with С. trachomatis and of the development of complicated forms of the urogenital chlamydial infection at men, modern peculiarities of the clinical course of the urogenital chlamydiosis have been reflected. Goal: studies of factors of the risk of contamination with С. trachomatis and development of aggravates forms of urogenital chlamydial infection and the analysis of modern clinical peculiarities of the disease in men of the reproductive age. Маterials and methods. 40 men were examined, among them 20 with urogenital chlamydial infection of lower segments of the genitourinary tract and 20 with complicated forms of urogenital chlamydial infection. The group of comparison comprised 20 men, not having clinical and laboratory features of sexually transmitted diseases and inflammatory diseases of the urogenital tract. Along with the analysis of anamnesis data of the clinical picture was performed the instrumental (transrectal ultrasonic research of the prostate) and the laboratory examination, using the microscopic, bacteriologic and molecular and biologic methods. Results. The authors established factors of risk of the contamination with urogenital chlamydial infection (age between 25 and 39 y.o., existent sexual contacts with two and more sexual partners, big number of sexual partners during the sexual practice) and factors of the risk of development of complicated forms of the chlamydial infection (patient age between 25 and 45 y.o. and the disease, lasting for more than 1 month). Main clinical implications of chlamydial urethritis and prostatitis are described.
Biological therapy of patients with severe psoriasis
Authors: NV KUNGUROV MM KOHAN , KENICKSFEST Y V , Keniksfest Yu V
Published: February 2022

Results of the clinical survey of 22 patients suffering from heavy forms of psoriasis have been submitted. The efficiency and safety of infliximab therapy has been evaluated during 48 weeks of patients’ survey.
Capabilities of the basic treatment preparations in the combined treatment of psoriasis
Authors: Hobeysh M M , Monakhov K N , Sokolovsky E V
Published: February 2022

Target. Research of the efficiency of Isida substances in the complex therapy of psoriasis. Маterial and methods. The research comprises 30 patients with psoriasis, treated in hospital (15 — with limited vulgar psoriasis and 15 — with palm and foot psoriasis) with Isida substances (cream gel for dry and sensible face and body skin and cream gel for hands). Results. The good efficiency and tolerance are highlighted: the decrease of PASI index by 53,6% at patients with limited vulgar psoriasis and by 47,4% at patients with palm and foot psoriasis. The dermatologic life quality index at all patients has decreased by 55,9%.
Therapy of associated urogenital infections
Authors: RAHMATULINA M R
Published: February 2022

Goal: Studies of the efficiency, safety and tolerance of safocide substance at patients with sexually transmitted diseases, associated with bacterial vaginosis and urogenital candidosis. Маterials and methods. The open direct not comparative study comprised 50 patients (25 men and 25 women). The complex of laboratory research comprised the microscopic research, bacteriological research for the identification of N. gonorrhoeae, Т. vaginalis, opportunistic pathogens; research by PCR method for the identification of С. trachomatis and M. genitalium; syphilis and HIV determination by the method of the immune & enzyme analysis. Results. After the therapy with safocide substance the eradication of pathogenic origination was achieved at 98% of patients. The authors revealed the low frequency of side effect development as well as the high level of the therapeutic compliance.
A case study of Mibellis disease with unilateral lesion foci
Authors: Proshutinskaya D V , Tekucheva L V , Katunina O R , Trofimchuk I A , Balabekova F G , Proshutinskaya D V , Tekucheva L V , Katunina O R , Trofi mchuk I A , Balabekova F G
Published: February 2022

A case study of the classical form of a rare form of inherited dermatosis, Mibellis disease, featuring unilateral position of the foci
in a child aged 3. A histological examination revealed aggregations of parakeratotic cells in epidermis being characteristic of
Mibellis disease.
Evaluation of clinical efficacy of treating patients sufferingfrom atopic dermatitis with drugs containing Aicida, anantiseptic stimulator of Dorogov
Authors: KLYuChAREVA S V , PIRYaTINSKAYa V A , KLYUCHAREVA S V , PIRYATINSKAYA V A
Published: February 2022

The article presents the results of a study of efficacy of using Aicida, a cosmetic drug with such an active substance as ASD (Dorogovs
antiseptic stimulator) in a liposomal form providing for the target delivery of the drug to deep skin tissues, for treatment of
patients with atopic dermatitis.
It also demonstrates high efficacy and good tolerance of the cosmetic product in patients with medium to severe forms of atopic
dermatitis.
Search for potential biomarkers of inveterate dermatoses by means of proteomic analysis
Authors: BRATSEVA YE V , MOSHKOVSKY S A , ZNAMENSKAYA L F , KUBANOVA A A , KUBANOV A A
Published: February 2022

The review covers the key achievements of proteome studies using mass spectrometry and two-dimensional electrophoresis methods in the field of dermatology Works studying the most prevalent chronic dermatoses such as psoriasis, atopic dermatitis, acne vulgaris and mycosis fungoidea are examined. Proteome analysis in dermatology is a promising technique today because it makes it possible to study molecular pathogenic mechanisms of skin chronic diseases in a greater detail. In addition, proteome technologies are aimed at searching for potential disease biomarkers and targets for drugs.
Prevalence of urogenital inflammatory diseases associated with genital mycoplasms. Treatment efficacy
Authors: LYSENKO O V , KUZNECHENKOVA T V , IGLIKOV V A , DERYABINA V P
Published: February 2022

Examination of 15765 women by PCR or culture method in the Southern Urals revealed genital mycoplasmas (M.hominis, M.genitalium, Ureaplasma spp.) in 25.8% of cases; they were more frequently met among socially non-adapted women (65,9% vs 17,2% in socially adapted group of women). Prescription of Josamycin (Wilprafen®), 500 mg TID for 10 days to women of both social groups provided the high level of antimicrobial effectiveness (92%) and favorable safety profile.
Overall Survival and Survival Time by Palliative Performance Scale: A Retrospective Cohort Study in Thailand
Authors: Vankun Pimprapa , Saramunee Kritsanee , Chaiyasong Surasak
Published: February 2022

Objectives:

The palliative performance scale (PPS) is a useful tool for predicting the survival time of palliative patients and for multidisciplinary teams in designing an appropriate care plan for patients and their families. This study aimed to (1) assess the survival time of palliative patients, (2) examine the factors associated with survival time and (3) investigate the proportion of patients whose survival time matched the time proposed by existing literature, within the Thai population.

Materials and Methods:

A retrospective cohort study was conducted with data drawn from five hospitals in one of the north-east provinces in Thailand. The study population comprised patients with a palliative diagnosis (ICD10: Z51.5) who had registered in one of the five hospitals between 1 October 2015 and 30 September 2017. Kaplan–Meier survival analysis was used to assess overall survival time and an extended Cox regression model to identify predictors of survival.

Results:

Of the 2792 registered patients, 1163 were included in the analysis. Most patients were male (55.62%), with a mean age of 64.59 years (±15.38), and were covered by the universal coverage insurance (77.72%). Approximately half (56.23%) of the participants had cancer and about a quarter (27.13%) had an initial PPS result of 30. The overall median survival time was 14 days (mean = 64.08, 95% CI: 12–16). Three significant predictors for survival included sex, hospital and initial PPS score.

Conclusion:

The survival time of palliative patients was relatively short. Sex, hospital and initial PPS were significant predictors of survival. The median survival time by PPS was similar to the values reported by the previous study but proportion of correct prediction was low. Therefore, it might be necessary to investigate the survival time of palliative patients by country independently.
THE USE OF ROSETTA STONE LANGUAGE LEARNING SOFTWARE IN TEACHING LISTENING: DOCUMENTARY RESEARCH
Authors: Kurniawan Dendy , Bunau Eusabinus , Wardah Wardah
Published: February 2022

This study focused on analyzing the use of Rosetta Stone Language Learning Software in teaching listening comprehension. Based on three previous journal from different universities in Indonesia the writer found that selected institutional repository website in Indonesia discusses about using Rosetta Stone Language Learning Software in teaching listening comprehension. The data described the facts on the use of Rosetta Stone based on the results of research by three researchers which have been published in three scholarly publications in Indonesia. This research is to find out the effectiveness of Rosetta Stone Software in teaching listening comprehension, this study had two data, the primary data (research journals) and secondary data (books). The conclusion that can be taken based on these research reports is the use of Rosetta Stone Software in improving students’ listening skills is effective. There are significant differences in learning listening comprehension between those who had been taught by using Rosetta Stone media and those who had not been taught by using Rosetta Stone media in terms of the scores the students got in the pre-test and post-test.
Molecular docking studies of Alpinia galanga metabolites against human placental aromatase for estrogen-dependent breast cancer treatment
Authors: MANZANO JOE ANTHONY , CRUZ CECIL LAURENCE III , MACABEO ALLAN PATRICK
Published: February 2022

Breast cancer is the leading cause of cancer-related deaths among women. With the clinical success of several synthetic aromatase inhibitors (AIs) as therapeutic agents in post-menopausal estrogen receptor-positive breast cancer, natural products have been tapped in search of chemically diverse compounds with potential better effectiveness against aromatase while conferring reduced adverse effects. Alpinia galanga is among the Philippine native medicinal plants with extensive studies on its phytopharmacological properties yet reports on its human placental aromatase inhibitory activity remain rudimentary. Thus, a total of 119 database-derived A. galanga secondary metabolites was molecularly docked onto the catalytic site of human placental aromatase using the UCSF Chimera platforms according to the AutoDock Vina Broyden-Fletcher-Goldfarb-Shanoo (BFGS) algorithm. Drug-likeness was assessed in silico using SwissADME. Of the screened compounds, galanolactone (1), 4-(3,4-dimethoxy-trans-cinnamoyl)-trans-cinnamic acid (2), isocoronarin D (3), quercetin (4), β-sitosterol (5), (E)-8ß,17-epoxylabd-12-ene-15,16-dial (6), galangin (7), labda-8(17),12-diene-15,16-dial (8), 7-(4-Hydroxy-3-methoxyphenyl)-1-phenylhept-4-en-3-one (9), and 3,5,7-trihydroxy-4-methoxyflavanone (10) conferred highest binding affinities against aromatase ranging from binding energies of -8.7 to -8.0 kcal/mol with notable formed hydrogen bonds and interactions against key amino acid residues. Top-ranked compounds exhibited druggability with at most one violation of the Lipinski Rule of Five (LRo5). Overall, the study indicates the potential of top A. galanga secondary metabolites as promising drug pharmacophores in developing therapeutics against breast cancer.
Coevolución Microbiota-Humano y sus implicaciones en salud: de cazadores recolectores a sedentarios industrializados
Authors: G-Santoyo Isaac , Urquiza Marín Héctor , Martínez-Pelayo Mariana , Jiménez-Trejo Francisco Javier , Aguilar- Díaz Hugo , Tapia Rodríguez Miguel
Published: February 2022

Los seres humanos somos holobiontes, estamos compuestos por los genomas de microorganismos que han coevolucionado con nosotros a lo largo de la historia evolutiva de la especie. El microbioma bacteriano intestinal es el más representativo debido a su gran diversidad de funciones. Los recientes cambios en el estilo de vida de las poblaciones humanas modernas se han convertido en  presiones ecológicas drásticas para estos microorganismos. Las medidas destinadas a matar o limitar a patógenos, combinadas con otros factores como los alimentos procesados, han tenido consecuencias no deseadas para el ecosistema microbiano humano, incluidos cambios difíciles de revertir. La alteración del microbioma y la consiguiente pérdida de sus atributos funcionales podrían explicar el drástico aumento de enfermedades no transmisibles durante los últimos 30 años. Esta revisión explora las intrincadas conexiones entre la evolución del hombre, sus cambios recientes en las prácticas de vida que han impactado el ecosistema microbiano con el que ha coevolucionado, y sus consecuencias en la salud de las poblaciones modernas.
Apis mellifera y miRNAs: modelo natural de longevidad y una perspectiva hologenómica del envejecimiento
Authors: Roque Ramírez Bladimir
Published: February 2022

La longevidad de un organismo se favorece cuando existe una adecuada homeostasis entre el huésped y su microbiota intestinal. Existen pocos alimentos con la capacidad de extender el tiempo de vida útil de un organismo, la Jalea Real (JR) en la abeja Apis mellifera es uno de ellos. El potencial nutriepigenético de la JR se encuentra en sus componentes protéicos, ácidos grasos, metabolitos y microRNAs (miRNAs) que la hacen un nutracéutico importante. En esta revisión abordamos un enfoque hologenómico del proceso de envejecimiento y longevidad haciendo énfasis en el uso de los miRNAs presentes en la JR y la posible modulación que éstos podrían tener sobre la microbiota intestinal.
DAILY COMMUNICATION PATTERNS OF SOCIAL INTERACTION IN BATAK TOBA LANGUAGE
Authors: Sitompul Theresia Friska Damayanti , Perdana Indra , Misrita Misrita
Published: February 2022

This research deals with the investigation of daily communication patterns of social interaction in Batak Toba language. The major issues in this research were the application of daily communication patterns in aspects of social interaction where the patterns were found. Besides, this research also found the way daily communication patterns in social interaction in Batak Toba language are expressed. The results show that the patterns in social interaction in Batak Toba language are found in many aspects, they are: (1) greetings, (2) self-introduction, (3) offer, (4) giving, (5) apologizing, (6) permissions, (7) invitations, (8) reply, (9) requests, (10) regrets, and (11) leave taking. As far as the research had been done, the way the patterns in Batak Toba language are expressed by using terms of kinship such as amang, inang, tulang, nantulang, amang boru, namboru, ito, lae, hela, parumaen, amang bao, inang bao, bere, paraman, appara, etc. Sociolinguistically, there is not any fixed patterns for each of the routines above because they depend on some social factors, such as, terms of kinship, age, gender, and familiarity.AbstrakPenelitian ini membahas tentang investigasi pola komunikasi interaksi sosial sehari-hari dalam bahasa batak toba. Isu utama dalam penelitian ini adalah penerapan pola komunikasi sehari-hari dalam aspek interaksi sosial dimana pola tersebut ditemukan. Selain itu, penelitian ini juga menemukan cara pengungkapan pola komunikasi sehari-hari dalam interaksi sosial dalam bahasa batak toba. Hasil penelitian menunjukkan bahwa pola interaksi sosial dalam bahasa batak toba ditemukan dalam banyak aspek, yaitu: (1) salam, (2) perkenalan diri, (3) menawarkan, (4) memberi, (5) meminta maaf, ( 6) izin, (7) undangan, (8) balasan, (9) permintaan, (10) penyesalan, dan (11) pengambilan cuti. Sejauh penelitian yang telah dilakukan, cara pola dalam bahasa batak toba diungkapkan dengan menggunakan istilah kekerabatan seperti amang, inang, tulang, nantulang, amang boru, namboru, ito, lae, hela, parumaen, amang bao, inang bao, bere, paraman, appara, dll. Secara sosiolinguistik, tidak ada pola yang tetap untuk setiap rutinitas di atas karena bergantung pada beberapa faktor sosial, seperti, istilah kekerabatan, usia, jenis kelamin, dan keakraban