bluuebunny/crossref_metadata_2025 huggingface dataset:
Yrittäjämäisiä ja työllistettäviä korkeakoulutettuja kasvattamassa: menestyjiä vai uupuneita suorittajia?
Authors: Siivonen Päivi
Published: December 2023

Tämä kirjoitus pohjautuu ”Korkeakoulusta valmistuneiden työllistettävyys ja sosiaalinen positioituminen työmarkkinoille” -hankkeessa (2018–2022) tehtyyn tutkimukseen. Yrittäjämäisyyttä ja työllistettävyyttä tarkastellaan kriittisestä näkökulmasta: miten opiskelijat ja erityisesti kaupalliselta alalta valmistuneet asemoituvat ja pyrkivät vastaamaan työllistettävyyteen ja siihen liittyviin ihanteisiin ja vaateisiin? Entä millaisia seurauksia yksilölle itselleen on jatkuvasta itsensä muokkaamisesta työllistettävyyden ihannemittoihin? Tutkimus tuo esiin, että kaupalliselta alalta valmistuneet maisterit ovat omaksuneet yrittäjämäisyyden ja työllistettävyyden yksilökeskeiset ihanteet varsin kritiikittömästi. He esittävät itsensä ihanteiden mukaisina, koska omaa arvoa ja asiantuntijuutta ”täytyy” osoittaa ja todistella sekä itselle että muille. Nuorta ikää ja siitä johtuvaa työkokemuksen puutetta sekä naissukupuolta pyritään paikkaamaan korostamalla sosiaalisuutta, innokkuutta ja kunnianhimoista huippusuorittamista. Syrjintään ja vähättelyyn vastataan huippusuorittamisella ja eteen tulevat esteet ylitetään omin voimin. Oman osaamisen ja kyvykkyyden osoittaminen itselle ja muille vahvistaa omaa pätevyyttä työntekijänä. Metelin nostaminen bisnesorganisaatioiden epätasa-arvoisista rakenteista ei palvelisi tätä päämäärää. Itsensä esittäminen työllistettävänä on kuitenkin jo itsessään kuluttavaa.

Epätasa-arvoisiin rakenteisiin liittyviä näkökulmia olisi tärkeää integroida korkeakoulutukseen ja erityisesti yrittäjyyskasvatukseen ja tarkastella työpahoinvointia rakenteellisena eikä pelkästään yksilöpsykologisena ongelmana.
Behavior of the DenStream Clustering Algorithm for Attack Detection in the Internet of Things
Authors: Tazima Gabriel Keith , Zarpelao Bruno
Published: December 2023

Multiple attack detection schemes based on supervised batch learning are presented in the literature as an alternative to improve Internet of Things (IoT) security. These schemes require benign and malicious traffic samples for training and are unable to easily adapt to changes in the analyzed data. In this work, we study how we can use DenStream, an unsupervised stream mining algorithm, to detect attacks in IoT networks. This type of algorithm does not require labeled examples and can learn incrementally, adapting to changes. We aim to investigate whether attacks can be detected by monitoring the behavior of DenStream's clusters. The results showed that DenStream could provide indicators of attack occurrence in TCP, UDP, and ICMP traffic.
Նորագույն միջատասպանների փորձարկումներ կարադրինայի դեմ Արարատի մարզի լոլիկի տնկարկներում
Authors: Թերլեմեզյան Հ. Լ. , Սարգսյան Մ. Ա. , Հարությունյան Հ. Ռ. , Կարապետյան Գ. Ա․ , Մկրտչյան Հ. Ն.
Published: December 2023

2021-2022 թթ.-ին կատարված հետազոտություններով հաստատվել է, որ Արարատի մարզի Տափերական համայնքի լոլիկի տնկարկներն ունեցել են կարադրինայի թրթուրներով բարձր բնակեցվածություն, որոնց դեմ փորձարկվել են քիմիական տարբեր խմբերի պատկանող նորագույն միջատասպաններ: Իրականացված հետազոտությունների արդյունքում ապացուցվել է, որ փորձարկված ոչ բոլոր պատրաստուկներն են եղել արդյունավետ կարադրինայի դեմ:
Исследования, проведенные в 2021-2022 годах, подтвердили, что томатные насаждения общины Таперакан Араратской области имеют высокую численность заселенности личинками карадрины, против которых были испытаны новейшие инсектициды, относящиеся к разным химическим группам. В результате проведенных исследований доказано, что не все испытанные препараты были эффективны против карадрины.
Studies conducted in 2021-2022 confirmed that the tomato plantations of the Taperakan community of the Ararat region have a high population of caradrin larvae, against which the latest insecticides belonging to different chemical groups were tested. As a result of the conducted studies, it was proved that not all tested preparations were effective against caradrin.
The factors affecting consumer’s perception about credit cards usage: A study in Melaka, Malaysia
Authors: Loong An Tay , Ramasamy Suganthi , Yee Yen Yuen
Published: December 2023

The objective of this study is to examine factors affecting consumers’ perception on credit card usage. This study implemented the non-probability sampling technique as it is the most convenience sampling method for the questionnaire survey for this study. The analysis was conducted by collecting 200 samples in Melaka, Malaysia and applying SERVQUAL model as the base model for this study. The model examines the impact of service quality, perceived benefits, bank policies and consumers’ attitude in influencing consumers’ perception on credit card usage. This study used multiple linear regression to analyze the factors affecting consumers’ perception on credit card usage. The findings conclude that service quality, perceived benefits, bank policies and consumers’ attitude have significant positive effect on the consumers’ perception on credit card usage.
EFEITOS DA COVID-19 NA GESTAÇÃO E INFLUÊNCIA DA GESTAÇÃO NA DOENÇA
Authors: Thompson Côrtes Thayla , Boechat Melado Sofia , Alves Linause Emelyn , Rocha Souza Vitória , Ramos de Souza Carvalho Fábio , Carrijo-Carvalho Linda Christian
Published: December 2023

A COVID-19 tem sido considerada uma doença sistêmica causada pelo novo coronavírus, o que gera preocupações quanto às consequências para a saúde da gestante e do concepto. O conhecimento dos possíveis efeitos na gestação causados pelo vírus e de como as alterações na gestante influenciam o curso da doença pode direcionar intervenções adequadas para o manejo correto em pacientes suspeitas. O artigo traz uma revisão de dados publicados na literatura com o objetivo de identificar possíveis complicações perinatais e obstétricas devido à infecção pelo SARS-CoV-2, observar a transmissão vertical, e analisar os impactos da gestação no curso clínico da COVID-19. As alterações anatômicas e fisiológicas na gestante, como a elevação do diafragma e a imunossupressão, a tornam mais susceptível à infecção. Por outro lado, a imunossupressão pode ser considerada um fator positivo a fim de minimizar o agravamento da síndrome inflamatória multissistêmica associada à “tempestade de citocinas”. Obesidade, doenças cardiovasculares e diabetes aumentaram o risco de gravidade da doença nas gestantes. A principal consequência observada para o recém-nascido foi a prematuridade. Evidências demonstraram a possibilidade de transmissão vertical e também a imunização passiva do feto. A imunização de gestantes com as vacinas atualmente oferecidas parece ser a principal medida de proteção para a mãe e o feto.
NGHIÊN CỨU SỰ BAY HƠI NƯỚC, CO NGÓT VÀ KHẢ NĂNG HÚT NƯỚC CỦA BÊ TÔNG TỰ LÈN CÓ HÀM LƯỢNG TRO BAY CAO SỬ DỤNG CỐT LIỆU THÔ TÁI CHẾ
Authors: Nguyễn Hùng Cường
Published: December 2023

Trong quá trình hoạt động xây dựng, lượng chất thải rắn khó phân hủy thải ra môi trường rất lớn. Lượng chất thải rắn này có thể được tái sử dụng để làm cốt liệu trong ngành công nghiệp bê tông. Qua đó giảm tiêu hao năng lượng, phát thải khí nhà kính và tiết kiệm tài nguyên tự nhiên. Bài báo này trình bày kết quả nghiên cứu thực nghiệm về sự ảnh hưởng của cốt liệu lớn tái chế (RCA) đến một số tính chất gồm sự bay hơi nước, biến dạng dẻo, co khô và độ hút nước của bê tông tự lèn có hàm lượng tro bay cao. Nghiên cứu sử dụng cốt liệu lớn tái chế với hàm lượng thay thế cốt liệu lớn tự nhiên lần lượt 0%, 50%, 75% và 100%, hàm lượng tro bay chiếm 50% thể tích bột. Kết quả nghiên cứu cho thấy có thể sử dụng tối đa 100% RCA, kết hợp với hàm lượng tro bay 50% thể tích bột để chế tạo SCC có tỷ lệ nước bay hơi giảm 17,76%, biến dạng dẻo tăng 42%, co khô tăng 31,43% và độ hút nước tăng rất ít, chỉ khoảng 2,63% so với mẫu đối chứng (sử dụng cốt liệu lớn tự nhiên).
PENGARUH ANTARA EMOTIONAL EXHAUSTION DAN JOB-RELATED AFFECTIVE ILL-BEING TERHADAP JOB SATISFACTION YANG DIMEDIASI OLEH PERFORMANCE PADA KARYAWAN DEVELOPER PERUMAHAN PROVINSI BANTEN
Authors: Putri Nursifa  , Hilma Halimatus Sa’diah  , Netania Emilisa
Published: December 2023

Penelitian ini meneliti pengaruh Emotional Exhaustion dan Job-related Affective Ill-being terhadap Kepuasan Kerja yang dimediasi oleh Kinerja pada karyawan yang bekerja sebagai Developer di Proyek Perumahan Provinsi Banten. Studi ini bertujuan untuk memahami dampak kelelahan emosional dan gangguan emosional yang terkait dengan pekerjaan terhadap kepuasan kerja sambil mempertimbangkan peran mediasi dari kinerja kerja. Melalui analisis empiris dan data yang dikumpulkan dari karyawan yang bekerja dalam domain ini, penelitian ini menjelajahi hubungan antara kondisi emosional, tekanan terkait pekerjaan, kepuasan kerja, dan kinerja kerja. Temuan ini mengungkapkan adanya interaksi kompleks di antara variabel-variabel tersebut, menyoroti pentingnya kesejahteraan emosional dan faktor-faktor terkait pekerjaan dalam menentukan kepuasan kerja di kalangan pengembang perumahan di Provinsi Banten.
HOMOLOGAÇÃO DA SENTENÇA PENAL ESTRANGEIRA: A TRANSFERÊNCIA DE EXECUÇÃO DA PENA
Authors: Valle de Brito Débora
Published: December 2023

O presente artigo aborda o procedimento de homologação de sentença penal estrangeira para fins de execução da pena, conforme previsto na Lei de Migração. Foi abordada a defesa cabível e, ao final, foi proposta alteração do Regimento Interno do Superior Tribunal de Justiça.
EVALUATING THE EFFECT OF PRODUCTS EXTRACTED FROM PANAX BIPINNATIFIDUS SEEM ON MULTIPLE MYELOMA CELLS
Authors: Vũ Thị Thu , Pham Thi Bich , Pham Trong Kha , Ngô Thị Hải Yến
Published: December 2023

Panax bipinnatifidus Seem (PB) is a precious medicinal plant in Vietnam. Although known for its many biological activities, the impact of this herb on multiple myeloma has not been elucidated. Objective: The study was conducted to evaluate the effects of total saponin extract from PB on the viability, reactive oxygen species (ROS), and mitochondrial cardiolipin content of multiple myeloma cells. Methods: Human myeloma cell line (KMS-20) cells were divided into 2 groups: control group and experimental group. In the control group, cells were grown in medium containing DMSO 0.05%. In the experimental group, cells were grown in medium containing total saponin extract (PB-TS) at different concentration ranges. Taxol is an anti-cancer drug used as a positive control in the study. Cell viability, ROS, and cardiolipin content were determined using suitable kits. Results: IC50 values of PB-TS for KMS-20 cells were 4.43±0.78 (µg/ml), higher than the IC50 value of Taxol (2.88±0.51 ng/ml). Besides, the CM-H2DCFDA fluorescence density of the cell group treated with Taxol and PB-TS increased to 121.52 ± 5.16% and 134.27 ± 3.59% compared to the control group (p<0.05). Moreover, the NAO fluorescence density of the cell group treated with Taxol and PB-TS also decreased to 62.73±6.87% and 41.56± 8.52%, respectively (p<0.05 compared with the control). Conclusion: The results of the study showed that total saponin from PB exhibited strong toxicity to KMS-20 cells through stimulation of ROS production and reduction of mitochondrial cardiolipin content.
MỨC ĐỘ MẤT ĐOẠN LỚN CỦA ADN TY THỂ Ở BỆNH NHÂN UNG THƯ ĐẠI TRỰC TRÀNG
Authors: Phạm Thị Bích , Tạ Văn Tờ , Trịnh Hồng Thái
Published: December 2023

Mục tiêu: Xác định được mức độ mất đoạn lớn của ADN ty thể ở mẫu mô u, mô lân cận u và mẫu máu của bệnh nhân ung thư đại trực tràng (UTĐTT) qua đó đánh giá mối liên quan giữa mức độ mất đoạn với các đặc điểm bệnh học, so sánh mức độ mất đoạn giữa mẫu máu của bệnh nhân ung thư với mẫu máu của người khỏe mạnh làm đối chứng.  Phương pháp: Mức độ mất đoạn lớn của ADN ty thể đã được xác định bằng phương pháp PCR định lượng (real -time PCR). Mức độ mất đoạn được so sánh bằng các kiểm định thống kê phù hợp. Chúng tôi đã phân tích mức độ mất đoạn trên bộ mẫu từ 94 bệnh nhân UTĐTT, trong đó 54 cặp mẫu mô u và lân cận u (LCU) được cung cấp bởi bệnh viên K, 40 cặp mẫu mô u và LCU có kèm theo mẫu máu của 40 bệnh nhân được cung cấp tại Bệnh viện Quân Y 103. Mẫu máu của 67 người khỏe mạnh được sử dụng làm đối chứng. Kết quả: Nghiên cứu đã xác định được mức độ mất đoạn lớn của ADN ty thể trên mô u, mô LCU, mẫu máu ở một nhóm bệnh nhân UTĐTT người Việt Nam và mẫu máu đối chứng tương ứng là 56,89%; 58,09%; 59,37% và 53,61%. Mức độ mất đoạn ở mẫu máu của bệnh nhân cao hơn so với mẫu máu đối chứng (p < 0,05). Mức độ mất đoạn không phụ thuộc vào độ tuổi, giới tính và các đặc điểm bệnh học. Kết luận: Phần lớn bệnh nhân có mức độ mất đoạn thuộc khoảng 50-60%. Mức độ mất đoạn ở mẫu máu của bệnh nhân cao hơn so với mẫu máu đối chứng (p < 0,05). Mức độ mất đoạn không phụ thuộc vào các đặc điểm bệnh học của bện nhân. Sự tương quan về mức độ mất đoạn giữa mẫu mô và máu của bệnh nhân UTĐTT là tương quan yếu (p > 0,05).
Evaluación de la piedra termal como cimentación en la interacción suelo-estructura en edificaciones medianas
Authors: Paucar Chanca Fortunato , De la Cruz Palomino David , Taipe Miguel
Published: December 2023

El presente estudio tiene por objetivo determinar la influencia de la piedra termal como cimentación en la interacción suelo-estructura, para ello se ha extraído las muestras de piedra termal in situ que posteriormente fueron ensayados en los laboratorios de la Escuela Profesional de Ingeniería Civil de la Universidad Nacional de Huancavelica para la determinación de los módulos de elasticidad, densidad, humedad saturada, ángulos de fricción y cohesión, también de la misma forma las propiedades de una edificación convencional de mediana altura, los cuales fueron procesados para determinar la capacidad de carga de piedra termal mediante el método Xiao-Li Yang y Jian-Hua Yin para suelos rígidos, los modelos dinámicos propuestos por Villarreal (2006), para determinar los coeficientes de rigidez tanto en estado saturado, seco y por último con los datos de este último se realizó un análisis dinámico de una edificación tipo dual de cinco niveles, considerando interacción suelo-estructura con la ayuda del programa SAP 2000, obteniendo los siguientes resultados: la capacidad de carga de la piedra termal estado seco es 4.42 kg/cm2 y estado saturado 4.19 kg/cm2, concluyendo que no influye significativamente en los resultados, con lo que respecta a los coeficientes de rigidez del estado saturado son mayores en mínimas proporciones, con mayor diferencia en el método Sargsian y menor en Barkan, llegando a la conclusión de que no influye significativamente en los resultados.
A Comparative Study of Options with Reference to ICICI Bank, SBI and Axis Bank
Authors: Susmitha Ms. , Sreyasree Ms.
Published: December 2023

Options trading is a dynamic and sophisticated field that shapes investment strategies for big banking organizations in the complex world of financial markets. With a focus on three major participants in the Indian banking industry—ICICI Bank, State Bank of India (SBI), and Axis Bank—this study conducts a thorough comparative analysis. The study aims to dissect and compare the complex tactics, positions in the market, and general performance of these banks in the field of options trading. It provides a thorough analysis of market positioning and competitiveness as well as deep insights into the complex strategies used by each bank. Additionally, it looks to pinpoint the crucial elements of success as well as the difficulties these financial organizations face in the intricate world of options trading. Insightful comparative studies, the discovery of original tactics, an assessment of market positioning, and comprehensive insights into the elements determining success or difficulties faced by ICICI Bank, SBI, and Axis Bank in the ever-changing world of options trading are among the anticipated results. For investors, financial analysts, and regulators who want to understand the intricacies of options trading in the banking industry, this might be a useful tool.
Het ontbinden van een meerpartijenovereenkomst
Authors: Rijsterborgh A.J.
Published: December 2023

Het ontbinden van een meerpartijenovereenkomst

Rechtspraak en literatuur over de ontbinding van overeenkomsten tussen meer dan twee contractspartijen zijn zeldzaam. Dat is opmerkelijk, omdat in de praktijk toch veel meerpartijenovereenkomsten worden gesloten en de wetgever hiervoor met artikel 6:279 lid 2 en 3 van het Burgerlijk Wetboek (BW) zelfs een bijzonder ontbindingsregime heeft opgetuigd. Vermoedelijk maakt onbekend onbemind, want anders is moeilijk verklaarbaar dat bijvoorbeeld in een land als België meer rechtspraak en literatuur over dit onderwerp bestaat. Een andere mogelijke verklaring is dat artikel 6:279 BW door sommigen simpelweg als ‘ondoorgrondelijk’ wordt beschouwd.

In dit artikel wordt daarom stilgestaan bij de ontbinding van meerpartijenovereenkomsten.
De kunst van de onvoorspelbaarheid: hoe concentraties de speelbal van een politiek speelveld werden
Authors: Roscam Abbing Felix
Published: December 2023

De kunst van de onvoorspelbaarheid: hoe concentraties de speelbal van een politiek speelveld werden

In dit artikel wordt een overzicht gegeven van recente ontwikkelingen ten aanzien van concentraties. Er geldt binnen Europa (maar ook daarbuiten) momenteel een verscherpt toezicht op concentraties, zowel wat betreft inhoudelijke beoordeling als wat betreft detectie en onderzoek. Zo hebben de Commissie en lidstaten verschillende tools om niet meldingsplichtige concentraties alsnog te kunnen beoordelen. Daarnaast zijn er ook steeds vaker verschillende FDI-meldingen nodig, en sinds kort ook FSR-meldingen bij de Commissie. Het eens ongenaakbare one-stop-shop-beginsel voor de beoordeling van concentraties lijkt inmiddels een ver verleden.
De Europese Commissie heeft haar regels voor horizontale samenwerkingsovereenkomsten bijgewerkt: een materiële herziening die meer rechtszekerheid belooft of een routinematige facelift?
Authors: Gornall Helen , Aulja Shubhanyu Singh , de Vries Laura
Published: December 2023

De Europese Commissie heeft haar regels voor horizontale samenwerkingsovereenkomsten bijgewerkt: een materiële herziening die meer rechtszekerheid belooft of een routinematige facelift?

De Europese Commissie heeft op 1 juni 2023 twee herziene horizontale groepsvrijstellingsverordeningen vastgesteld en herziene richtsnoeren over horizontale samenwerking gepubliceerd. Dit artikel geeft een overzicht van de verschillende vormen horizontale samenwerkingsovereenkomsten die onder de horizontale groepsvrijstellingsverordeningen en de richtsnoeren vallen en belicht enkele van de belangrijkste wijzigingen in de regels. In het laatste onderdeel wordt ingegaan op de wijze waarop de Commissie omgaat met duurzaamheidsovereenkomsten en wordt die wijze ook vergeleken met de aanpak van de Nederlandse Autoriteit Consument & Markt (ACM) en wordt besproken hoe de ACM haar positie wil laten rijmen met die van de Commissie.
Synthesis, Characterization, Biological Properties, ADMET and Drug-likeness Analysis of Mn (II) complexes with Schiff Bases Derived from Sulphathiazole and 4-diethylaminosalicyaldehyde/Salicyaldehyde
Authors: Haruna A , Sirajo I T , Rumah M M , Albashir Y
Published: December 2023

Mn (II) complexes were synthesized with the Schiff base ligand obtained by the condensation of sulfathiazole with 4-diethylaminosalicyaldehyde/Salicyaldehyde. Their characterization was performed by elemental analysis, molar conductance, melting points, magnetic susceptibility, infrared, and UV–Vis spectral analysis. The results suggest that the Schiff bases and their complex are synthesized in excellent yield, molar conductance studies on the complexes indicated they were non-electrolytic. The IR data indicated that the Schiff base ligand is tridentate coordinated to the metallic ion with two N atoms from the azomethine group and thiazole ring and one O atom from the phenolic group. The electronic spectral study showed octahedral geometry for all the complexes which are further supported by magnetic moment values. The ligand and its complexes were screened against four bacterial and two fungal strains using the disk diffusion method. The antimicrobial evaluation results revealed that the metal (II) complexes exhibited higher antimicrobial activity than the free Schiff base ligand. The ADMET and drug-likeness studies of the synthesized ligands indicated that the Schiff base ligands fulfill Lipinski’s, Ghoose, Veber, Egan, and Mugge rules but the complexes showed some deviations. They also displayed low toxicity levels.
Data Retention in Labour Law
Authors: Janashvili Lela
Published: December 2023

The age of information has a massive impact on society. New possibilities including search engines, sensor networks, security agencies, marketers and highly accessible databases require multiple and careful legal frameworks that will help to protect personal data on an advanced level. Its protection is a subject of comprehensive analysis that requires the assessment of multiple international or domestic legislation. Multiple perspectives regarding the protection of personal data in the employment context make the subject more important as it’s crucial to make a proper assessment in order to determine the differences in between the visions of legislators as all of them are trying to do their best in order to protect the personal data but they still have many dissimilarities. This paper analyses the differences in European and Georgian Legislation and determines the main aspects of data retention in labour law. European treaties, directives and domestic law of Georgia might carry certain similarities and values but every aspect carries lots of important outcomes from the perspective of data protection that needs to be properly addressed.
Abordagens de etnoastronomia nos livros de ciências distribuídos em 2020 pelo Programa Nacional do Livro e do Material Didático (PNLD)
Authors: Dos Santos Osmair Carlos , Quinta de Brito Darlan , Guimarães Maciel Felippe , Ferreira Marcello , Da Silva Filho Olavo Leopoldino , Lessa do Couto Roberto Vinícios , Corci Batista Michel
Published: December 2023

This work seeks to characterize ethnoastronomy themes in science textbooks distributed, in 2020, by the Brazilian's National Program of Didactic Book (PNLD), taking as a focus the ninth year of Elementary School, the series in which astronomy obtains greater curricular space. The research, of a qualitative nature, sought a theoretical and historical review of the object, as well as a new enunciation of its rationality through a reconstructive hermeneutics, using content analysis resources to evaluate the frequency of citations to less valued cultures. socially and approaches that value multiculturalism in the chosen corpus. As a result, it was found that eleven of the twelve works analyzed made reference to the sky seen from the perception of non-dominant cultures. However, in most of these works, the approach still presents a simplistic vision that does not reflect multiculturalism in teaching proposals. It is, therefore, essential that these materials, which are mandatory for use and reach tens of millions of Brazilian students, value the contributions and perspectives of different cultures, incorporating them into the teaching-learning processes.
Resiliencia, motivación de logros y grado de satisfacción con las carreras de estudiantes universitarios de Física mecánica
Authors: Sosa María Angélica , Benítez Víctor Daniel , Espinosa Teresa Genara , Rodríguez María Daniela , Sureda Silvia Cristina , Sosa Nora Mabel
Published: December 2023

This paper analyzes the degree of resilience, achievement motivation and satisfaction with the career they have chosen, presented by Biochemistry and Pharmacy students of the Facultad de Ciencias Exactas, Químicas y Naturales (Universidad Nacional de Misiones) studying Physics l. For data collection, anonymous surveys were used through the Google platform, which were then statistically analyzed. The results obtained show that students perceive themselves as highly resilient and have a high degree of satisfaction with the career they chose. The analysis of the achievement motivation variable showed that there is a large gap between their expectations regarding grades and the results of the evaluation instances.
Referenciais teórico-metodológicos na pesquisa em ensino de física entre 2001 e 2023: metalinguagens e relações saber-poder-subjetividade
Authors: Ferreira Marcello , Lessa do Couto Roberto Vinícios , Guimarães Maciel Felippe , Silva Filho Olavo Leopoldino da , Corci Batista Michel
Published: December 2023

The field of research in Physics Teaching in Brazil has expanded notably in recent decades, driven by the growth and consolidation of postgraduate studies resulting from a succession of public policies, the engagement of research and teaching institutions and adherence to a regime of goals and results imposed varied mercantile interests. This state of affairs mediates the configuration of the field of knowledge, the respective interactions of forces and the characteristics of the subjects thus constituted. Such dynamics are modulated by power relations expressed in the semantic dimension (discursive, strictly speaking), which makes it possible to describe and analyze the metalanguage that mirrors them. With this aim, the work reveals the disciplining element of the object between the years 2001 and 2023, articulating the Foucauldian categories “knowledge-power-subjectivity”. Objectively, a bibliographical review was carried out, resulting in 96 publications analyzed: (1) using content analysis techniques, categorizing the main theoretical references, methodological procedures and themes covered; and (2) through a meta-analysis, obtaining lexical classes that corroborated the preliminary results and reinforced theoretical articulations. By derivation, an archaeogenealogical crossing of results unfolded, discursively retracing ways of being and ways of resistance and search for freedom.
Sequência didática para mudanças conceituais no ensino de física: desenvolvendo o conceito de centro de gravidade
Authors: Feu Teixeira Santiago Tatiane , Dias Menezes Paulo Henrique
Published: December 2023

This article presents a didactic strategy, formed by a set of activities at increasing levels of complexity, designed for the development of the concept of center of gravity, based on Piaget and Garcia's cognitive model for conceptual changes. The bases that underlie this construction are composed of the dialectical triads of the stages: intra, inter and trans-object. This teaching model enables students to develop increasingly comprehensive concepts, breaking paradigms and expanding their ability to observe, compare and transform knowledge. The method was applied in physics classes with 2nd year high school students. During the application, the evolution of the concept of balance point was examined, in its differentiation with the center of gravity, as an indicator capable of pointing out the students' ways of understanding. The results indicate the potential of balancing and unbalancing processes, based on uncertainty shared among students and between them and the teacher, as an essential element in building the concept of center of gravity in a meaningful way.
Uma aula de mecânica no parque de diversões: proposta de ensino de física no espaço não-formal
Authors: Sousa Chagas Fábio Henrique de , Gomes de Amorim Ronni Geraldo
Published: December 2023

In this work, we present a proposal for teaching Physics in a non-formal teaching environment. Specifically, a didactic material was built, based on Ausubelian assumptions, to be applied in a Physics class held in an amusement park. The content addressed includes topics of mechanics related to the first year of high school. The research was carried out within the scope of the National Professional Master's Degree in Physics Teaching at the University of Brasília. The product was applied in a private school in Brasília-DF, and the class took place in the Amusement Park, located at the Sarah Kubitschek city park. The post-application interviews showed that the didactic material used, and the teaching methodology adopted were well evaluated by the students.
Seed dormancy mechanism and dormancy-breaking methods in wild raspberry (Rubus fraxinifolius Poir.)
Authors: RAHMAWAN Hatika , QADIR Abdul , SARI Maryati , SURYA Muhammad Imam
Published: December 2023

Raspberries are subtropical plants that contain high levels of vitamin C, antibacterial and anti-inflammatory. They can potentially be developed as horticultural and medicinal plants. Dormancy is a challenge in the cultivation of raspberries (Rubus fraxinifolius Poir.). This study was conducted as two separate experiments. The first experiment aimed to identify the dormancy mechanism of R. fraxinifolius seed. In a two-factor factorial design, the first factor was seed storage, as unstored and three-month-stored, and the second factor was chemical-immersed treatment consisting of control, H2SO4, acetone, GA3, KNO3, H2SO4-GA3, acetone-GA3, H2SO4-KNO3, acetone-KNO3. The second experiment was aimed at determining dormancy-breaking methods for R. fraxinifolius seeds. In main plots were filter paper and cocopeat germination substrates. The subplots included control, immersed with distilled water, H2SO4, ultrafine bubble water, and temperature treatment at −80 °C, 50 °C, and 70 °C. The germination of unstored and three-month-stored seeds increased after H2SO4 treatment (36 to 82% and 82 to 94%, respectively). Seed germination increased after three months of storage. There was an increase in cytokinin hormone levels along with germination enhancement. The seeds went into physical dormancy because their seed coat was hard, and they went into physiological dormancy because of low cytokinin concentration. Stratification at 50 °C increased germination (78.5 to 93.0%), reduced dormancy intensity (15 to 6.5%), and increased the percentage of the speed of germination (1.99 to 3.12 ) on filter paper substrate.
New insights regarding the taxonomy and phylogeography of Onobrychis montana DC. subsp. transsilvanica (Fabaceae)
Authors: BĂCILĂ Ioan , ŞUTEU Dana , COSTE Ana , BALÁZS Zoltan R. , COLDEA Gheorghe
Published: December 2023

Onobrychis montana DC. Subsp. transsilvanica (Simonk.) Jáv. (Fabaceae) is a plant taxon, endemic to the South-Eastern Carpathians, whose taxonomic status is treated inconsistently by the classic taxonomy based on morphological traits. In a previous study, by sequencing several chloroplast DNA regions and AFLP genotyping, we tried to elucidate the controversy concerning its taxonomic status in relation to the more widespread O. montana DC., and determined its phylogeographic structure within the Carpathians. The present study, based on DNA fingerprinting by seven SSR markers, brings more insights on this problematic taxon by conferring higher resolution and sub-clustering previously identified phylogeographic groups. However, the newly SSR genetic data are in agreement with molecular evidence revealed by AFLP and chloroplastic SNPs and do not support O. montana DC. Subsp. transsilvanica (Simonk.) Jáv. As a distinct species from O. montana DC.
Dual response of cerebrocortical blood flow and arterial blood pressure to transient CO2 stimulus after inhibition of nitric oxide synthesis in rats
Authors: Wołk Robert , Siemińska Jolanta , Trzebski Andrzej
Published: December 2023

Inhibition of nitric oxide synthase (NOS) by Nitro-L-arginine-methyl-ester (L-NAME 15 mg and 70 mg/kg i.v.) in 16 male Wistar rats anaesthetized with urethane, paralysed and artificially ventilated, increased significantly local peripheral vascular resistance in the parietal cortex (CVR) along with augmentation of the mean arterial blood pressure (MAP) and no change of the local cerebrocortical blood flow (CBF) recorded with a Laser-Doppler-Flowmeter. In 11 rats L-NAME reversed a pressor effect of brief hypercapnia induced by 10% CO2/air mixture (PaCO2 84.1 +/- 5 mm Hg) into a depressor response, reduced CBF response proportionally to the reduction of MAP and did not influence CVR response to CO2. In 5 rats L-NAME did not abolish the central pressor effect of a CO2-stimulus and significantly augmented CO2-induced vasodilatatory response in the cortex (43.4 +/- 24% before L-NAME and 137.8 +/- 38.8% after L-NAME) by a larger reduction of CVR (-11 +/- 8% before L-NAME and -47.1 +/- 7.6% after L-NAME). It is concluded that NO does not mediate the vasodilatatory effect of brief hypercapnia in the cortex. NO appears critical for the central pressor effect of CO2. In those rats in which the central pressor effect of a CO2-stimulus was not abolished by an NOS blocker, an increased CBF and augmented decrease in CVR was observed during brief hypercapnia. Possible mechanisms of this dual responsiveness of cortical blood flow and arterial blood pressure to CO2, induced by inhibition of NOS, are discussed.
N-methyl-D-aspartate- induced 45Ca2+ release from pre-labelled adult rat hippocampus in vivo
Authors: Łazarewicz Jerzy , Rybkowski Waldemar , Puka-Sundvall Małgorzata , Gadamski Roman , Hagberg Henrik
Published: December 2023

We report the results of microdialysis experiments investigating the NMDA-induced release of intracellular Ca2+ in different brain regions. Microdialysis probes were implanted stereotaxically into the striatum, thalamus and hippocampus dentate gyrus (DG) of adult rats. Dialysates were analysed for alterations in the concentration of ionized Ca2+ in an initially calcium-free medium and for changes in 45Ca efflux from the pre-labelled endogenous Ca2+ pools. The application of 5 mM of NMDA to the dialysis medium for 20 min in the striatum, resulted in increases in Ca2+ and 45Ca concentrations by 25% and 35% respectively. After NMDA perfusion in the hippocampus DG and in the thalamus, decreases in the Ca2+ concentration to 65.6% and 38.6% of the basal level respectively, were accompanied by increases in 45Ca efflux, exceeding 1,500% of the basal level in the hippocampus. Cell swelling, and the corresponding reduction of the extracellular space volume was insufficient to explain the huge increase in 45Ca efflux. Thus, our experiments demonstrated that in vivo in the rat hippocampus DG, NMDA induces the release of 45Ca to the extracellular space from unidentified intracellular calcium stores.
Perseverative errors and reversal of a visual discrimination following basal forebrain lesions in the rat
Authors: Wilson W. , Cook Jennifer
Published: December 2023

Rats with electrolytic lesions of the nucleus basalis magnocellularis were compared to sham-lesioned rats in the retention of a continuously reinforced lever-pressing response and in the acquisition and reversal of a visual discrimination task. The muscarinic agonist pilocarpine, in conjunction with the peripheral muscarinic antagonist methyl-scopolamine, was administered in three doses to subsets of each group during acquisition. The lesion interfered with retention of the lever-pressing response. It did not affect the rate of acquisition of the visual discrimination, but facilitated reversal, and increased the number of perseverative errors made by the rats. Pilocarpine's only notable effect was to increase the latency to respond.
Two components of long-term memory
Authors: Woźniak Piotr , Gorzelańczyk Edward , Murakowski Janusz
Published: December 2023

The existence of two independent components of long-term memory has been demonstrated by the authors. The evidence has been derived from the authors' findings related to the optimum spacing of repetitions in paired-associate learning. The two components are sufficient to explain the optimum spacing of repetitions as well as the spacing effect. Although the molecular counterparts of the two components of memory are not known, the authors provide a collection of guidelines that might facilitate identification of such counterparts.
Implications of the subtilisin/kexin-like precursor convertases in the development and function of nervous tissues
Authors: Marcinkiewicz Mieczysław , Seidah Nabil , Chrétien Michel
Published: December 2023

Furin, PC1, PC2, and PC5 represent mammalian convertases (PCs) found in endocrine, central and peripheral nervous tissues, which cleave a number of precursors at basic residues normally processed in vivo. Typical bonds cleaved by PCs include the pairs Lys-Arg, Arg-Arg and Arg-X-Lys/Arg-Arg. These cleavage sites have been detected following coexpression of each convertase in cell lines together with different precursors as models, including proopiomelanocortin (POMC), proinsulin and proNGF and proBDNF. The presence of PCs and different precursors was revealed by in situ hybridization or immunocytochemistry in cultured AtT-20 cells, in the developing CNS, pituitary, and pancreatic islets. In an experimental model of epilepsy in which epileptiform activities were provoked by kainic acid administration, we observed a similar transient expression of furin and PC1 as compared to that of NGF and BDNF. In conclusion, it is proposed that under different stimuli various precursors are activated by a unique cocktail of convertases, each of which either alone or in combination with others acts to process inactive precursors, and thereby playing an important role in development and in the plasticity of the neuronal system.
Disturbances of acetyl-CoA, energy and acetylcholine metabolism in some encephalopathies
Authors: Szutowicz Andrzej , Tomaszewicz Maria , Bielarczyk Hanna
Published: December 2023

Acetyl-CoA provision to the synaptoplasmic comparment of cholinergic nerve terminals plays a regulatory role in the synthesis of acetylcholine. The disturbances in glucose utilization and in decarboxylation of the end product of its matabolism pyruvate, are considered to be significant factors causing cholinergic deficits in several diseases of the central nervous system. In this article we review data concerning role of acetyl-CoA in patomechanisms of disturbances of cholinergic metabolism in Alzheimers disease, thiamine deficiency, inherited defects of pyruvate dehydrogenase and diabetes.
Development of oscillatory activity in the limbic cortex in vitro
Authors: Konopacki Jan
Published: December 2023

The generation of EEG theta rhythms in the mammalian limbic cortex is a prime example of rhythmic activity that involves central mechanisms of oscillations and synchrony. In 1985 for the first time we demonstrated that bath perfusion of the hippocampal formation slices with cholinergic agonists resulted in theta-like oscillations. Since this initial demonstration of the in vitro theta activity, we have carried out a number of experiments in an attempt to answer the general question: what are the similarities between the cholinergic-induced in vitro theta and theta rhythm which naturally occurs in the in vivo preparation. Thus far, our in vitro studies provided strong evidence that the in vitro recorded theta oscillations replicate many physiological and pharmacological properties of the in vivo observed theta rhythm. In addition, our studies validate the in vitro maintained limbic cortex as a model for studying central mechanisms of oscillations and synchrony.
Variety of muscle responses to tactile stimuli
Authors: Czarkowska-Bauch Julita
Published: December 2023

Influences exerted by tactile stimuli on the muscle activity were investigated with two methods: (1) analysis of kinematics and electromyographic (EMG) activity of eight forelimb muscles during contact placing (CP) reactions elicited by tactile stimuli applied to the dorsal, medial or lateral sides of the paw in cats, and (2) the Hoffmann (H) - reflex technique to quantify the effects of the tactile stimuli on the excitability of the alpha motoneurones of the soleus muscle in awake rats. The first group of the data showed that the tactile stimuli applied to dorsal, medial or lateral aspects of the paw led to different strategies of the forelimb movements during CP reactions. These differences arose from various patterns of activation of the elbow flexor and extensor muscles at the beginning of CP reactions and a various involvement ofthe medio-lateral components of movements, depending on the site of the tactile stimulus application. With the H-reflex technique it was found that the tactile stimulus diminished the excitability of alpha motoneurones of the soleus muscle when applied to the skin overlying the lateral side of the ankle joint. This effect was in line with the observation that the tactile stimulus applied to the lateral side of the paw activated the elbow flexor muscles but not their antagonists to initiate CP reaction.
Locomotor capacities after complete and partial lesions of the spinal cord
Authors: Rossignol Serge , Chau Connie , Brustein Edna , Bélanger Marc , Barbeau Hughes , Drew Trevor
Published: December 2023

This paper first reviews some of the observations made on the locomotor capabilities of several animal species with a special emphasis on cats and including primates and man after complete spinal lesions. We show that animals can perform well-coordinated walking movements of the hindlimbs when they are placed on a treadmill belt and that this locomotion is also adaptable to speed and perturbations. Cats with partial spinal lesions of the ventral and ventrolateral parts of the cord can perform voluntary quadrupedal locomotion overground or on the treadmill albeit with deficits in weight support and interlimb coordination. We also show that some drugs such as clonidine (an alpha-2 noradrenergic agonist) can be used to trigger locomotion in early-spinal cats and discuss the effects of various neurotransmitter systems on the expression of the locomotor pattern in both complete and partial spinal cats. It is concluded that a pharmacological approach could be used, in combination with other approaches, such as locomotor training and functional electrical stimulation, to improve locomotor functions after spinal cord injuries in humans.
Rat cerebral mitochondrial glutaminase activity is unaffected by moderate hyperammonemia in two models
Authors: Albrecht Jan , Hilgier Wojciech , Faff Lidia
Published: December 2023

The phosphate-dependent (PAG) and phosphate-independent (PIndG) glutaminase activities were measured in cerebral perikaryal mitochondria derived from rats subjected to ammonium acetate- induced "simple" hyperammonemia (SHA) or thioacetamide-induced hepatic encephalopathy (HE). These two moderately hyperammonemic conditions were previously found to be accompanied by pronounced changes in virtually all the enzyme activities coupling the tricarboxylic acid cycle to the synthesis and metabolism of the excitatory neurotransmitter glutamate. Both PAG and PIndG remained unaffected by SHA or HE, indicating that they do not contribute to the cerebral glutamine/glutamate imbalance associated with both conditions.
Difluoromethylornithine counteracts lesion-induced astrogliosis in rat hippocampus: enhancement of inhibitory effect by combined treatment with GM1 ganglioside
Authors: Jegliński Wojciech , Skup Małgorzata , Zaremba Małgorzata , Oderfeld-Nowak Barbara
Published: December 2023

The effect of difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase (ODC), the rate limiting enzyme of polyamine biosynthesis, and its combined action with GM1 ganglioside, was studied on the GFAP content in a model of remote astrogliosis evoked in the hippocampus by lateral fimbria transection. DFMO markedly suppressed hippocampal gliosis as measured by GFAP immunoblotting seven days postsurgery. Combined treatment with DFMO and GM1 ganglioside - a substance which alone also counteracts hippocampal gliosis, produced a stronger suppressive effect than DFMO. The results support the hypothesis of a causal link between lesion induced events: polyamine biosynthesis and astroglial reaction. Potentiation of the inhibitory effect of DFMO by GM1 ganglioside suggests that the latter does not act through the mechanism involving ODC suppression.
Differential expression of NMDA-evoked 45Ca release in rat hippocampal regions in vivo
Authors: Łazarewicz Jerzy , Rybkowski Waldemar
Published: December 2023

Recently we detected NMDA-induced Ca release in the rat dentate gyrus in vivo, attributable to the Ca2+ induced Ca2+ release (CICR) from the endoplasmic reticulum via ryanodine channels. In these experiments we compare expression of NMDA-evoked 45Ca release in the rat dentate gyrus (DG), CA1 and subiculum (SUB). The rationale behind introducing this study is that these hippocampal regions are known to differ in their levels of ryanodine receptors. The release of 45Ca was studied using in vivo microdialysis combined with measurements of 45Ca efflux from prelabelled hippocampal regions. It was shown that NMDA-induced 45Ca release, highly pronounced in the rat DG/CA4, is significantly less expressed in the CA1, whereas in the SUB an NMDA-evoked decrease in 45Ca efflux was noted. This corresponds to distribution of ryanodine receptors in the rat hippocampus, known from the literature. Expression of NMDA-evoked 45Ca release in these rat hippocampal regions which are enriched in ryanodine receptors supports our working hypothesis that CICR via ryanodine channels may be mainly responsible for 45Ca release.
c-fos expression as a tool to search for the neurobiological base of the sexual behaviour of males
Authors: Biały Michał , Kaczmarek Leszek
Published: December 2023

Elevated expression of c-fos mRNA and/or its protein (c-Fos) has been repeatedly observed following activation of brain cells with various stimuli. As a consequence it has been proposed that elevated c-fos expression may serve as a marker of neuronal activation reflecting a predisposal to long-term changes in cell functioning (neuronal plasticity). In studies on copulatory behaviour of male animals, elevated Fos immunoreactivity (related most probably to c-Fos) has been used by many researchers as a tool to reveal functional neuroanatomy of the behaviour. They found that brain regions such as medial preoptic area (MPOA), bed nucleus of stria terminalis (BNST), medial amygdala (MeAm) and central tegmental field (CTF) are always activated in a copulation-dependent manner in various species (rats and hamsters were the most often studied in this regard). This paper reviews the data gathered in this field, and discusses them in the context of a role of elevated Fos expression in acquisition vs. performance of the sexual behaviour.
Respiratory effects of serotonin challenge to pulmonary and laryngeal circulation in anaesthetized cats
Authors: Szereda-Przestaszewska Małgorzata , Wypych Beata
Published: December 2023

Administration of serotonin (5-HT) to pulmonary circulation elicits prompt apnoea, followed by subsequent tachypnoea. The present study was designed to ascertain whether 5-HT challenge into the laryngeal artery will evoke the full constellation of this chemoreflex and to examine the role of laryngeal sensory input and importance of vagal afferents in the respiratory sequelae. The experiments were done on 10 anaesthetized, spontaneously breathing cats. Laryngeal artery injections of 5-HT, similarly to intravenous challenge, caused apnoeas, which were significantly diminished by the section of cervical vagal trunks. Breathing frequency increased in all condtions on intravenous injection but only prior to vagotomy, when administered into laryngeal artery. With resumed breathing, the peak inspiratory airflows were significantly increased in the neurally intact, those treated by bilateral section of the superior laryngeal nerves (SLNs-cut) and vagotomized cats, with no difference between them and independent of the route of injection. The results show that serotonin chemoreflex could evolve from the laryngeal vascular bed and that laryngeal afferents do not contribute to the respiratory arrest.