bluuebunny/crossref_metadata_2025 huggingface dataset:
Ligand-dependent Notch signaling strength orchestrates lateral induction and lateral inhibition in the developing inner ear
Authors: Petrovic Jelena , Formosa-Jordan Pau , Luna-Escalante Juan C. , Abelló Gina , Ibañes Marta , Neves Joana , Giraldez Fernando
Published: May 2014

During inner ear development, Notch exhibits two modes of operation: lateral induction, which is associated with prosensory specification, and lateral inhibition, which is involved in hair cell determination. These mechanisms depend respectively on two different ligands, jagged 1 (Jag1) and delta 1 (Dl1), that rely on a common signaling cascade initiated after Notch activation. In the chicken otocyst, expression of Jag1 and the Notch target Hey1 correlates well with lateral induction, whereas both Jag1 and Dl1 are expressed during lateral inhibition, as are Notch targets Hey1 and Hes5. Here, we show that Jag1 drives lower levels of Notch activity than Dl1, which results in the differential expression of Hey1 and Hes5. In addition, Jag1 interferes with the ability of Dl1 to elicit high levels of Notch activity. Modeling the sensory epithelium when the two ligands are expressed together shows that ligand regulation, differential signaling strength and ligand competition are crucial to allow the two modes of operation and for establishing the alternate pattern of hair cells and supporting cells. Jag1, while driving lateral induction on its own, facilitates patterning by lateral inhibition in the presence of Dl1. This novel behavior emerges from Jag1 acting as a competitive inhibitor of Dl1 for Notch signaling. Both modeling and experiments show that hair cell patterning is very robust. The model suggests that autoactivation of proneural factor Atoh1, upstream of Dl1, is a fundamental component for robustness. The results stress the importance of the levels of Notch signaling and ligand competition for Notch function.
SWNT Composites with Compositionally Tunable Prussian Blue Nanoparticles for Thermoelectric Coordination Programming Materials
Authors: Nonoguchi Yoshiyuki , Murayama Tomoko , Ishizaki Manabu , Kanaizuka Katsuhiko , Kurihara Masato , Hata Kenji , Kawai Tsuyoshi
Published: May 2014

The self-assembly of Prussian blue nanoparticles and single-walled carbon nanotubes is demonstrated by using analytical TEM. The nanotube composites containing compositionally tunable Prussian blue nanoparticles are, for the first time, applied to finely modulate their Seebeck coefficients.
Characterization of Slag from Combustion of Pulverized Lignite with High Calcium Content in Utility Boiler
Authors: Pintana P. , Tippayawong N. , Nuntaphun A. , Thongchiew P.
Published: May 2014

The Mae Moh mine in northern Thailand, with its abundant lignite, is the primary energy source for the Mae Moh power plant, which uses pulverized coal combustion in superheated boilers to generate electricity for domestic consumption. The lignite reserves remaining in the mine may contain up to 40% CaO. Given this high calcium content, more frequent and severe slagging problems are likely to occur. To better understand the potential slag problem, this research investigates the characteristics and properties of the slag by collecting and analyzing different samples of boiler slag from the Mae Moh power plant. Employing scanning electron microscopy, energy dispersive X-ray spectroscopy, X-ray fluorescence, and X-ray diffraction, the surface morphologies of the different slag samples were found to be similar. The majority of the crystal surfaces were agglomerates of particle-like clay and irregular granules stacked together. The most abundant elements in the slag were oxygen, aluminum, silica and calcium. The major chemical components included CaO, SiO2, Al2O3, Fe2O3, and MgO. The minerals found in the slag were anorthite, gehlenite, akermanite, diopside, and esseneite. An increasing base-to-acid ratio reduced ash flow temperature. The Mae Moh lignite showed a medium to high slagging tendency. Increasing the slagging index led to a decrease in the ash fusibility temperature, due mainly to increasing amounts of Fe2O3 and CaO. From this study, the high CaO and Fe2O3 in the Mae Moh lignite clearly resulted in increased intensity of slag.
Deposition and Diagenesis of Steep-Slope Glutenite Reservoirs: Shengtuo Field, Eastern China
Authors: Zhang Penghui , Zhang Jinliang , Xie Jun , Lee YongIl , Zhang Ming , Ding Fang , Yuan Yong , Li Jingzhe , Zhang Xin
Published: May 2014

This study deals with the diagenesis of steep-slope glutenites in the view of relationship between depositional facies and diagenetic alterations. The Lower Member of Shahejie glutenites sit along steep slopes of an intracontinental lacustrine basin, which is an important area of hydrocarbon exploration in eastern China. This kind of reservoir rocks can be divided into three major depositional environments: transgressive fan deltas, channelized sediment flows and fluxoturbidite fans. The glutenites are lithic arkose and feldspathic litharenite having an average composition of Q35F36R29, rich in metamorphic rock fragments. Diagenetic processes that have affected the glutenites include mechanical and chemical compaction, dissolution of detrital grains, and cementation by quartz overgrowths, calcite, ankerite, kaolin, illite, chlorite, and mixed-layer illite-smectite clays, as well as formation of minor zeolite, epsomite, halite, and glauberite. Considering glutenites in different depositional environments experiencing different diagenetic evolution pathways along the lacustrine basin margin, a schematic model was constructed to predict diagenetic conditions within the defined depositional facies. This study reveals that the spatial and temporal distribution of diagenetic alterations within depositional facies, and provides important insights to the controls on reservoir quality evolution. In addition, findings of the study are applicable to other continental steep-slope glutenite reservoirs of lacustrine basins.
Drill String Failure Analysis and Erosion Wear Study at Key Point for Gas Drilling
Authors: Liu Shaohu , Zheng Hualin , Zhu Xiaohua
Published: May 2014

Erosion wear at the key point of a drill string is very severe in gas drilling. The investigation shows that failure of drill string is very serious in gas drilling. The probability of failure of the drill pipe and the drill collar is the highest in all the drill string, and the near placement of pin and box is often damaged. According to the investigation of drill string failure and erosion theory, the erosion model of drill string is established. The erosion rate at the key point of a drill string is solved using the Grant and Tabakoff formula. Different factors, such as gas injection volume, rate of penetration (ROP), cuttings' diameter, cuttings' shape factor, cuttings' number, and temperature of the annulus, are considered. The result shows that the erosion rate at the key point is more severe than that of other locations on the drill pipe. Because of higher peak stress for a drill string with eroded wear, there is a more serious effect on the residual strength of a drill string with eroded wear. Crack forms easily, due to severe erosive wear and deeper pits. Also, fracture failure of a drill string is caused by larger axial load and torque. In this paper, analysis of such influencing parameters as gas injection volume, ROP, cuttings' particle size, cuttings' shape factor, cuttings number and temperature of the annulus is conducted, among which gas injection volume, ROP and cuttings number are proven as the main controlling factors that affect the erosion wear at the key point of a drill pipe.
Radiometric Information from Airborne Laser Scanning for Archaeological Prospection
Authors: Briese Christian , Pfennigbauer Martin , Ullrich Andreas , Doneus Michael
Published: May 2014

Airborne laser scanning (ALS) is widely used for the sampling of large landscapes for different application areas. Since several years ALS data is also often used in archaeological prospection, e.g. in order to detect archaeological features beneath the vegetation canopy cover. For most of the applications only the geometric information provided by ALS is utilized. However, next to geometric information ALS provides radiometric information for each acquired point. For its practical usability radiometric calibration is essential. This contribution presents, next to the basic theory, a radiometric calibration workflow for ALS data. As a result calibrated spectral information is added to the ALS point cloud. This information can be used to generate images displaying reflectance at the wavelength of the ALS sensor. The presented calibration workflow is furthermore applied to different ALS missions carried out in the study area Carnuntum, Austria. Due to the usage of ALS sensors with different laser wavelengths, next to single wavelength ALS data, multi-wavelength reflectance data is presented and compared. Additionally, the multi-temporal characteristics of reflectance data are discussed briefly. Finally, the paper is summarized and an outlook into future research work is presented.
Digital Aléria: Multiresolution Technologies Arming International Collaboration to Restore the Past and Restart
Authors: Paolini P. , Simonetti F. Allegrini , Forti G. , Corrao A.
Published: May 2014

This paper reports about the last progressing results of our work, raised around the archaeological site of the ancient roman urbs of Aléria in Corsica (F), updated to January 2014. Our plan provides to resume the old excavation usable data, to realize a new survey of the site actual status and to collect all into a new 3D geodatabase, including any kind of historical, documental analog data, all reorganized into dedicated Cloud Platforms and Services for different uses, as a multipath solution to improve scientists' work and to promote tourism, both local and international.

The project initially focused on the forum, as the only accessible area, in these days enlarges its plans involving the nearby amphitheater and ramparts, just reorganized after the removal of old roofing. It somehow embraces even the nearby Carcopino Museum and the collected Etruscan and Roman finds as traces of the unruly diggings previously realized, to which we'll attempt to restitute logic and documented belonging.

Since the Aléria Carcopino Museum shows important archaeological evidences sharing the same origin with some finds exposed in the National Etruscan Museum of Villa Giulia in Rome, a new initiative was set up in these days by surveying the two museums' buildings, to create 3D georeferenced models as containers for sharing digital multiscale data made by innovative computational photography techniques there applied. This operation is now in place in the Villa Giulia Museum as a prototype to be after web-linked to the same survey model to be realized in Aléria.

Leading the whole project is the collaboration agreement between the “Collectivité Territoriale de Corse, secteur Archéologie”, and the Department of “Storia, Disegno e Restauro dell'Architettura” SAPIENZA, Italy, formally signed in year 2013.

The process employs many multiresolution surveying technologies: 3D Laser scanning, Topography, GPS and Dense Stereo Matching applied on site, on buildings and objects for manifold purposes; moreover Computational Photography techniques applied on Museum's halls, cabinets and exposed objects, to create digital and interactive exhibitions linking both nations. A GIS and WEBGIS workflow followed, to start collecting new and restored databases to build up a complete 3D geo-database with 3D Web scene to be shared in the GIS online Cloud Platform.
Finalizing a Low-Cost Photogrammetric Workflow: From Panoramic Photos to Heritage 3D Documentation and Visualization
Authors: d'Annibale E. , Tassetti A.N. , Malinverni E.S.
Published: May 2014

The research aims to optimize a workflow of architecture documentation: starting from panoramic photos and tackling available instruments and technologies the aim is to propose an integrated, quick and low-cost solution of Virtual Architecture. The broader research background shows how to use spherical panoramic images for the architectural metric survey. The input data (oriented panoramic photos), the level of reliability and Image-based Modeling methods constitute an integrated and flexible 3D reconstruction approach: from the professional survey of cultural heritage to its communication in virtual museum. The proposed work results from the integration and implementation of different techniques (Multi-Image Spherical Photogrammetry, Structure from Motion, Dense Image Matching and Image-based Modeling) with the aim to achieve high metric accuracy and photorealistic performance. Different documentation chances are possible within the proposed workflow: from the virtual navigation of spherical panoramas to complex solutions of simulation and virtual reconstruction. VR tools make for the integration of different technologies and the development of new solutions for virtual navigation. Image-based Modeling techniques allow 3D model reconstruction with photo realistic and high-resolution texture. High resolution of panoramic photo and algorithms of panorama orientation and photogrammetric restitution vouch high accuracy and high-resolution texture. Automated techniques and their following integration are subject of this research. Data, advisably processed and integrated, provide different levels of analysis and virtual reconstruction joining the photogrammetric accuracy to the photorealistic performance of the shaped surfaces. Lastly, new solutions of heritage interactive and immersive communication are tested as inevitable visualization consequence of previous experimental results.
Pocałunek przez ścianę – rosyjski film w polskiej szacie słownej
Authors: Krajewska Monika
Published: May 2014

A Russian film translated by Polish students

This paper presents the analysis of difficulties in translation into Polish of the Russian film Поцелуй сквозь стену (directed by Wartan Akopian, 2011). Quotes, foreign phrases, colloquialisms, occupational slang, word plays and, finally, word and visual plays are only some of the problems for students who begin to learn the art of translation. This translation project lasted from March to June 2012 and included a group of student‑volunteers of the Russian studies at the Nicolaus Copernicus University in Toruń. The project was finished by a show at the „Horyzont” Film Club in Gdańsk (the Russian Cultural Centre).
Website Morphing 2.0: Switching Costs, Partial Exposure, Random Exit, and When to Morph
Authors: Hauser John R. , Liberali Guilherme (Gui) , Urban Glen L.
Published: May 2014

Website morphing infers latent customer segments from clickstreams and then changes websites' look and feel to maximize revenue. The established algorithm infers latent segments from a preset number of clicks and then selects the best “morph” using expected Gittins indices. Switching costs, potential website exit, and all clicks prior to morphing are ignored. We model switching costs, potential website exit, and the (potentially differential) impact of all clicks to determine when to morph for each customer. Morphing earlier means more customer clicks are based on the optimal morph; morphing later reveals more about the customer's latent segment. We couple this within-customer optimization to between-customer expected Gittins index optimization to determine which website “look and feel” to give to each customer at each click. We evaluate the improved algorithm with synthetic data and with a proof-of-feasibility application to Japanese bank card loans. The proposed algorithm generalizes the established algorithm, is feasible in real time, performs substantially better when tuning parameters are identified from calibration data, and is reasonably robust to misspecification.

Data, as supplemental material, are available at http://dx.doi.org/10.1287/mnsc.2014.1961 .

This paper was accepted by Eric Bradlow, special issue on business analytics.
Paclitaxel and Carboplatin (TC) Regimen for Ovarian Cancer
Authors: Akin Julie M. , Waddell J. Aubrey , Solimando Dominic A.
Published: May 2014

The complexity of cancer chemotherapy requires pharmacists be familiar with the complicated regimens and highly toxic agents used. This column reviews various issues related to preparation, dispensing, and administration of antineoplastic therapy, and the agents, both commercially available and investigational, used to treat malignant diseases.
Administration of Extended Infusion Piperacillin-TazobactamWith the Use of Smart Pump Technology
Authors: Maddox Megan L. , DeBoer Erica C. , Hammerquist Rhonda J.
Published: May 2014

Background

For beta-lactams, the parameter that best predicts bacterial killing is the length of time the antibiotic concentration exceeds the minimum inhibitory concentration (MIC). Studies have demonstrated improved outcomes with extended infusion (4-hour) piperacillin-tazobactam (P-TZ) compared with traditional immediate infusions.

Objectives

To describe how one institution made the conversion from immediate infusion of P-TZ to a 4-hour extended infusion utilizing an approved automatic therapeutic substitution, staff education, and smart pump technology, and to examine the impact of this conversion on patient length of stay and pharmacy costs.

Methods

With approval from the Pharmacy and Therapeutics (P&T), Antimicrobial Stewardship, and Medical Executive Committees, the decision was made to automatically convert all P-TZ orders to a standardized 4-hour infusion given every 8 to 12 hours depending on renal function. The medical records of all adult patients receiving P-TZ during 12 months pre implementation and 24 months post implementation of a 4-hour extended infusion of P-TZ were retrospectively analyzed for length of stay and mortality. The cost of P-TZ was also assessed during these time periods.

Results

With the help of smart pump technology, our institution successfully completed a conversion to 4-hour extended infusion P-TZ. Through this conversion, pharmacy expenditure of P-TZ was reduced by 38%; the total cost savings was $387,980.62 for the 24-month postintervention phase. Extended infusion P-TZ reduced hospital length of stay by 0.6 days ( P < .05), resulting in an additional cost savings of $1,689,480 for the 24-month postintervention phase. A conservative estimate of total cost savings to the hospital in the first 24 months, including the reduction in P-TZ expenditures, was $2,077,460.
Sofosbuvir
Authors: Cada Dennis J. , Cong Jasen , Baker Danial E.
Published: May 2014

Each month, subscribers to The Formulary Monograph Service receive 5 to 6 well-documented monographs on drugs that are newly released or are in late phase 3 trials. The monographs are targeted to Pharmacy & Therapeutics Committees. Subscribers also receive monthly 1-page summary monographs on agents that are useful for agendas and pharmacy/nursing in-services. A comprehensive target drug utilization evaluation/medication use evaluation (DUE/MUE) is also provided each month. With a subscription, the monographs are sent in print and are also available on-line. Monographs can be customized to meet the needs of a facility. A drug class review is now published monthly with The Formulary Monograph Service. Through the cooperation of The Formulary, Hospital Pharmacy publishes selected reviews in this column. For more information about The Formulary Monograph Service, call The Formulary at 800-322-4349. The May 2014 monograph topics are droxidopa, elosulfase alfa, vorapaxar, ramucirumab, and pimavanserin. The DUE/MUE is on droxidopa.
Health System Dashboard: It's All Coming Together
Authors: Felkey Bill G. , Fox Brent I.
Published: May 2014

We are all familiar with the function and purpose of dashboards in our automobiles. Dashboards that serve a similar purpose are increasingly being found in hospitals and health systems. In this installment, we describe the convergence that is enabling dashboards to be powerful components of care delivery workflow. We also describe several example dashboards and how they are used.
Reviews
Authors: Goes Eunice , Hourmat Bernardo , Marques Paulo
Published: May 2014

A Esquerda Radical em Portugal e na Europa: Marxismo, Mainstream ou Marginalidade? / The Radical Left in Portugal and Europe: Marxism, Mainstream or Marginal?, Luke March and André Freire (2012) Vila do Conde: Quidnovi, 288 pp., ISBN 9789895549399, p/bk, Є13.99

The Routledge Handbook on Civil-Military Relations, Thomas C. Bruneau and Florina Cristiana Matei (eds) (2013) Routledge, London, 374 pp., ISBN: 9780415782739, h/bk, £140.

The Age of Dualization: The Changing Face of Inequality in Deindustrializing Societies, Patrick Emmenegger, Silja Häusermann, Bruno Palier and Martin Seeleib-Kaiser (2012) Oxford: Oxford University Press, 339 pp., ISBN: 9780199797899, p/bk, £27.50.
Does the macroeconomic context influence subjective well-being in Europe and Portugal? The puzzling case of the 2008 crisis
Authors: Lopes Helena , Calapez Teresa , Porto Carla
Published: May 2014

The happiness economics literature shows that, contrary to what happens in the long run, subjective well-being (SWB) and income evolve together in the short term. The aim of the present article is to examine whether this result holds in Europe, and in particular in Portugal, during the 2000s. The empirical study is based on the European Social Survey (ESS) micro-data, merged with Eurostat macroeconomic data (rate of change in gross domestic product (GDP), unemployment and inflation). Following the literature, our hypothesis is that self-reported well-being increases in expansionary periods and decreases in recessive ones. Results show that, while the association between well-being and macroeconomic fluctuations are as expected from 2002 to 2008, this is no longer the case when the 2010 data is included in the regression models. In fact, well-being increased in ten out of fifteen European countries after the 2008 crisis. Further examination of the Portuguese data shows that people of all age, education levels, health condition and employment status declared to be happier in 2010 when compared to 2008. Such a puzzling result may be explained by expectations and adaptation processes as well as by an increased awareness, possibly prompted by the crisis, that not only income but also social relationships count in life. Our results thus broadly confirm happiness economics findings: well-being is not exclusively linked with income.
The discursive analysis of body representation: A critical, realistic and embodied overview
Authors: Pereira Anabela
Published: May 2014

The aim of this article is to acknowledge the implications of addressing the visual representation of the body from a critical and realistic discursive perspective. Besides allowing the identification of the mechanisms for the artist’s name and work-recognition this perspective has allowed the study of body representation as language and as a common system of meanings, not just giving attention to the forms of connection between the image and speech or written text, but also to the rules, practices and social relations that produced and governed them. Also it has permitted interrogation of and reflection on the relation between two important categories used in the analysis of self-representation, that is, the relation between ‘artist’s identity’ and ‘work’s identity’ in the cases of Helena Almeida and Jorge Molder, whose works are characterized and recognized by the specific use of the artists body figures.
Ensinar Matemática com TIC: Em Busca de um Referencial Teórico
Authors: Sampaio Patrícia Alexandra da Silva Ribeiro , Coutinho Clara Maria Gil Fernandes Pereira
Published: May 2014

A integração da tecnologia no processo de ensino/aprendizagem não tem trazido grande sucesso educativo, tendo-se constatado que o apetrechamento das escolas com ferramentas educativas não é uma solução por si só. Torna-se necessário refletir sobre esta integração, surgindo um modelo teórico que interliga três componentes (pedagogia, tecnologia e conteúdo) com o contexto em que se está inserido. No caso particular da Matemática, este referencial denomina-se de TPACK matemático e desenvolve-se em torno de quatro grandes áreas: conceção e desenvolvimento de experiências e ambientes digitais de aprendizagem; ensino, aprendizagem e currículo matemático; análise e avaliação; produtividade e prática profissional. No entanto, não há uma aquisição imediata do TPACK por parte dos professores de Matemática, precisando de passar por um processo de cinco etapas para enfrentarem a decisão final de aceitar ou rejeitar uma tecnologia específica para o ensino da Matemática.
Formação de Professores para o Ensino Inicial da Leitura e da Escrita, na Década 1880, em São Paulo-Brasil
Authors: Mortatti Maria Do Rosário Longo , Pereira Bárbara Cortella , Pasquim Franciele Ruiz
Published: May 2014

Apesar de a Escola Normal de São Paulo ter sido objeto de muitos e importantes estudos e pesquisas no campo da história da educação brasileira, encontram-se ainda pouco explorados os aspetos específicos da formação desses professores, no que se refere a sua atribuição de ensinar a ler e a escrever. Com o objetivo de contribuir para a compreensão desses aspetos, focaliza-se, neste artigo, a formação de professores para o ensino inicial da leitura e escrita, no contexto das tentativas de regulamentar e reformar a instrução pública que se implementaram na Província/Estado de São Paulo, a partir da década de 1880, com a reabertura definitiva da Escola Normal situada na capital paulista.
Escarabeos del noreste de Hispania y del sur de la Galia: catálogo, nuevos ejemplares e interpretaciones
Authors: Almagro-Gorbea Martín , Graells i Fabregat Raimon
Published: May 2014

Catálogo de 72 escarabeos fenicios, griegos, etruscos y romanos hallados en el Nordeste de Hispania y en la Galia Mediterránea, desde Castellón hasta el Ródano, incluido el Valle del Ebro. Tras su estudio tipológico individual se ofrece una visión de conjunto de su contexto y significado para comprender la evolución socio-ideológica de las elites originarias de los Campos de Urnas desde inicios del siglo VI a.C., en que se datan los ejemplares más antiguos, hasta la romanización. Este estudio evidencia los mitos esenciales llegados a través de las culturas mediterráneas, especialmente de focenses y púnicos, que conformaron las creencias religiosas y la ideología de las elites prerromanas, por lo que constituyen un elemento insustituible en esos campos de estudio.
Las monedas de los campamentos romanos de campaña de las Guerras Cántabras del asedio de La Loma, Castillejo y El Alambre
Authors: Peralta Labrador Eduardo , Hierro Gárate José Ángel , Gutiérrez Cuenca Enrique
Published: May 2014

En este artículo presentamos los materiales numismáticos recuperados en las excavaciones realizadas en los campamentos romanos de campaña de las Guerras Cántabras de La Loma (Santibáñez de la Peña, Palencia) y Castillejo (Pomar de Valdivia, Palencia), y en la prospección realizada en el campamento de El Alambre (Valle de Valdelucio, Burgos). Entre otras cosas, se aportan nuevos datos para ajustar la cronología de las emisiones de monedas de Calagurris en época de Augusto.
Hallazgos monetarios de 1765 a 1831 en Toledo, Sevilla, Asturias, Cuenca, Madrid, Burgos, Albacete y Valencia, donados a la Real Academia de la Historia
Authors: Abascal Palazón Juan Manuel , Alberola Belda Antonio
Published: May 2014

En el Numario de la Real Academia de la Historia se conservan muchas piezas procedentes de colecciones sin procedencia topográfica conocida pero también algunos conjuntos de monedas que fueron entregados aquí tras su descubrimiento. Tras la revisión de la documentación conservada, presentamos aquí las monedas romanas de procedencia segura que ingresaron en la colección entre 1765 y 1831, incluyendo algunas noticias adicionales que se encuentran en las Actas académicas de ese período.
Ensayo tipológico para el estudio de cerámica prehistórica del País Valencià: aplicación a colecciones del Bronce final
Authors: García Borja Pablo , Pérez Jordà Guillem
Published: May 2014

Se presenta una propuesta de clasificación tipológica para las cerámicas realizadas a mano del País Valencià. Puesto que ya se ha demostrado válida para colecciones neolíticas y calcolíticas, en este trabajo se aplica a vajillas del Bronce final. La revisión de diferentes conjuntos ubicados al norte y al sur del río Vinalopó, y la realización de dataciones radiocarbónicas, nos han permitido establecer una periodización de estos conjuntos.
Los amuletos de la «tumba nº 5» de la necrópolis orientalizante de Les Casetes (Villajoyosa, Alicante)
Authors: Vaquero González Aránzazu
Published: May 2014

En este trabajo se realiza un estudio de los amuletos aparecidos en la denominada «tumba nº 5» de la necrópolis orientalizante de Les Casetes (Villajoyosa, Alicante) con el objetivo de llevar a cabo una identificación e interpretación de los mismos, así como del ritual en el que fueron empleados. Cabe señalar que los amuletos no eran objetos de «pacotilla», sino de gran importancia en las creencias diarias y funerarias, así como para conocer los contactos comerciales y las ideas religiosas.
Cerámica de barniz negro de época romana republicana en yacimientos celtíberos y carpetanos de la provincia de Guadalajara
Authors: Gamo Pazos Emilio , Azcárraga Cámara Sandra
Published: May 2014

En este artículo se acomete la actualización de los yacimientos de la provincia de Guadalajara en los que aparecen materiales de cronología romana republicana. Se cuenta con los resultados de antiguas prospecciones y excavaciones y, sobre todo, de las más recientes. Todo el conjunto ofrece una visión nueva sobre los inicios de la romanización en este territorio.
The Structure of Climate Skeptical Arguments. Conspiracy Theory as a Critique of Science Die Struktur klimaskeptischer Argumente. Verschwörungstheorie als Wissenschaftskritik
Authors: Soentgen Jens , Bilandzic Helena
Published: May 2014

Questioning and rejecting the scientific consensus on climate change causes, climate skeptics argue that climate science is involved in a global conspiracy, guided by self-interest and aspirations of societal change. On the basis of 97 climate skeptical non-fiction books, this article
reconstructs the logical structure of climate skeptical (or denialist) arguments, with a special focus on the construction of the causes for climate change. The analysis shows that climate skeptical arguments are made on three levels: on the level of insight from climate science, on the level
of an intuitive sociology of science and on a political/economic level, thus achieving the desired effect of moving the audience emotionally. The reconstruction of arguments may serve as a basis for more quantitative research, but it is also useful for entering the debate with climate skeptics
as it allows anticipating climate skeptical objections.
Mastermind of System Change. Karl Polanyi and the “Great Transformation” Vordenker einer nachhaltigen Gesellschaft. Karl Polanyi und die ,,Große Transformation“
Authors: Göpel Maja , Remig Moritz
Published: May 2014

Der oft nur begriffliche Rückgriff auf Karl Polanyis Analyse der ,,Großen Transforma tion“ greift zu kurz. Ein konsequenterer Blick darauf kann der Trans formationsforschung neue Impulse geben.
Gender in Climate Change. Social Differentiation in Adaptation Research Geschlechter im Klimawandel. Soziale Differenzierung in der Anpassungsforschung
Authors: Bauriedl Sybille
Published: May 2014

Reaktion auf fünf Artikel zur sozialwissenschaftlichen Anpassungsforschung in GAIA: T. Grothmann et al. (2011), U. von Winterfeld (2012), S. Beck et al. (2013), D. Gerten (2013), A. Brunnengräber, K. Dietz (2013)
Fuel Poverty in Germany: From a Buzzword to a Definition Energiearmut – vom politischen Schlagwort zur handlungsleitenden Definition
Authors: Tews Kerstin
Published: May 2014

Steigende Strompreise stellen die Sozialverträglichkeit der Energiewende infrage – Politik, Wirtschaft und Sozialverbände befürchten eine neue ,,Energiearmut“ bei einkommensschwachen Bevölkerungsschichten. Wird der Begriff Energiearmut aber handlungsleitend
definiert statt politisch instrumentalisiert, kann er helfen, die Energie wende sozialverträglich zu gestalten. Das britische Verständ nis von fuel poverty kann dabei als Vorbild dienen.
Towards a Theory of Transdisciplinary Research Auf dem Weg zu einer Theorie transdisziplinärer Forschung
Authors: Ukowitz Martina
Published: May 2014

Transdisziplinäre Forschung eröffnet einen sozialen Raum, in dem bestehendes Wissen verhandelt, neues generiert und an sozial robusten Problemlösungen gearbeitet wird. Für diesen Raum – die Agora – sind grundlegende Annahmen über die Voraussetzungen
von Erkenntnis und die Beschaffenheit des Wissens neu zu bestimmen. Dazu bedarf es einer Theorie, die den Kennzeichen transdisziplinärer Forschung – Anwendungsorientierung und Zusammenarbeit mit Stakeholdern – Rechnung trägt und geeignet ist, diese Forschungsform in der
akademischen Mainstreamwelt zu etablieren.
Sensory evaluation of sausage treated with and without grape extract
Authors: Scher Sheila Luciana , Sora Gisele Teixeira de Souza , Mardigan Laura Paulino , Rosa Cássia Inez Lourenzi Franco , Fuchs Renata Herrera Barros
Published: May 2014

The aim of this work was to carry out a sensory evaluation of sausages treated with and without grape extract. The acceptance test of the samples was conducted with a 9-point structured hedonic scale to evaluate flavor, appearance, odor and general impression. There was no significant difference between flavor and odor attributes which presented an overall score of 7.72, approaching the category of “liked very much”. Nevertheless, a significant difference was observed for appearance (sensory scores of 4.7 and 7.8) and general impression (6.16 and 7.56) of the samples with and without grape extract. These results showed that the dark color produced in the sausages after the grape extract treatment reduced the acceptance. As appearance is one of the most important attributes in food products, a major influence was caused by this attribute on the sausage general acceptance.

 

DOI: http://dx.doi.org/10.14685/rebrapa.v1i1.10

 
Influence of Bacillus Stearothermophilus generations in the production of its spores
Authors: Oliveira Roselene Ferreira , Lima Heron Oliveira dos Santos , Lima Mirela Vanin dos Santos
Published: May 2014

The validation of sterilization processes in food and pharmaceutical industries is a major tool for quality assurance, making the products safe, effective and reliable. Biological indicators, formed by spores of Bacillus stearothermophilus microorganisms considered at higher thermal resistance, are used to evaluate and monitor the physical parameters of a cycle of steam sterilization. In this way this study aimed to cultivate and characterize the microorganism Bacillus stearothermophilus generations, assessing the influence of these generations in the parameters of resistance, formation and concentration of its spores to be used in the production of biological indicators. The experiments were conducted cultivating the 1st, 2nd and 3rd generations of B. stearothermophilus in suitable culture media for sporulation, in Roux bottles, for a period of 15 days of incubation. During these 15 days, the sporulation process was evaluated by microscopy, according to Wirtz-Conklin's method, every 24 hours of incubation. The results showed that the generations do influence the sporulation process, indicating that the 3rd generation is the most suitable for the production of formed spores, in concentration and thermal resistance appropriate characteristics to the needs of a biological indicator to efficiently validate and monitor steam sterilization cycles.

 

http://dx.doi.org/10.14685/rebrapa.v1i1.12
Phenolic compounds of grape extract (Vitis labrusca) and their action on lactic acid bacteria
Authors: Scher Sheila L. , Fuchs Renata H. Barros , Sora Gisele T. de S. , Mardigan Laura P. , Kwiatkowski Angela
Published: May 2014

The Isabel grape is one of the main cultivars of Vitis labrusca, and it's a common, rustic and less demanding variety. The aim of this work was the obtention of  Isabel grape extract and the evaluation of its activity on the growth of Lactic Acid Bacteria. The effect of grape extract and ethanol on lactic acid bacteria growth was evaluated. The average of total phenolic compounds in the Isabel grape extract was 14,80mg/mL, less than literature data. The amount of phenolic compounds on grape extract can be influenced by the type of extraction and techniques used in the production of the extract and by the reactions that occurs during its storage. The Isabel grape extract was more efficient on reducing Lactic acid bacteria growth than ethanol.

 

DOI: http://dx.doi.org/10.14685/rebrapa.v1i1.7

 
Determination of the water sorption isotherms for cassava flour
Authors: Farias Juliana Fermino , Ferreira Mirele Fernandes , Santos Wagner André dos , Bona Evandro
Published: May 2014

Cassava is a nourishing food and widely consumed in Brazil in the form of flour. However, it is necessary a more detailed study of the physical-chemical properties of the cassava flour and thus optimize its processing steps such as drying. The objective of this work was to obtain the water sorption isotherms for the cassava flour at different temperatures. For this aim, experiments were carried out using the static method with saturated saline solutions at 30, 40, 60 and 70°C. The data obtained were adjusted on available literature equations using the software MATLAB R2007b. The results indicate that the temperature ranging from 40 to 70°C does not significantly influence the cassava flour equilibrium moisture. It was also found  that both Halsey and Smith's isotherm can be used to predict the cassava flour equilibrium moisture. Furthermore, it was observed a small variation in the equilibrium moisture for water activity ranging from 0 to 0.8.

 

DOI: http://dx.doi.org/10.14685/rebrapa.v1i2.21
Eating habits and nutritional status of hemodialysis patients
Authors: Nishiyama Márcia Fernandes , Meyer Juliane
Published: May 2014

Hemodialysis (HD) is a blood filtration process that removes excess of fluid and metabolites. The major determinants of morbidity and mortality in HD are the patients’ nutritional status and dialysis adequacy. Probably there is a significant interrelationship between these two factors, as well as patients receiving adequate dialysis have a higher overall wellness and consequently better food intake. The aim of this study was to identify eating habits and nutritional status of patients registered in the hemodialysis program in the city of Foz do Iguaçu-PR. Thirty-four patients were selected, 70.5% men and 29.5% women, in average 45 years old. To characterize the nutritional status were used Body Mass Index (BMI), total cholesterol, and Reduction Percentage Calculation of Urea (RPU). Dietary habits were investigated through a questionnaire on eating frequency. The results showed a predominance of normal individuals, according to BMI (47%), total cholesterol (60%) and RPU (80%) and the dietary habits showed that the results were not expected due to the socioeconomic level of patients. These results suggested that special attention must be given to maintaining the nutritional status of hemodialysis patients.

 

DOI: http://dx.doi.org/10.14685/rebrapa.v1i2.24
Information Asymmetry and Hybrid Advertising
Authors: Liu De , Viswanathan Siva
Published: May 2014

Pay-for-performance (P4P) pricing schemes such as pay per click and pay per action have increased in popularity in Internet advertising. Meanwhile, pay-per-impression (PPI) schemes persist, and several publishers have begun to offer a hybrid mix of PPI and P4P schemes. Given the proliferation of pricing schemes, this study examines the optimal choices for publishers. The authors highlight two-sided information asymmetries in online advertising markets and the consequent trade-offs faced by a high-quality publisher using P4P schemes. Pay-for-performance schemes enable a high-quality publisher to reveal its superior quality; however, such schemes may incur allocative inefficiencies stemming from inaccurate estimates of advertiser qualities. The authors identify conditions under which a publisher may opt for a PPI, P4P, or hybrid scheme and, in doing so, provide theoretical explanations for the observed variations in the pricing schemes and the increasing popularity of hybrid schemes. Using a new “uncompromised” equilibrium refinement, the authors find that the hybrid scheme can emerge as an equilibrium choice in a variety of conditions. In addition, they provide prescriptive guidelines for firms choosing between different pricing schemes.
First Mission to Pluto
Authors: Neufeld Michael J.
Published: May 2014

The complex and contested origins of the New Horizons mission to Pluto, launched by NASA in 2006, provides a window on how space science policy has been formulated in the United States before and after the turn of the twenty-first century, and how the shifting network of institutions that support and shape space science have changed since 1989. Those decades have so far been little studied except by policy scholars seeking lessons from the NASA Administrator Daniel Goldin’s attempt to force a small-spacecraft technological revolution on space science in the 1990s. The New Horizons case study reveals a shift in the balance of power around 2000 among the important players in the field, increasing the influence of non-NASA actors—notably Congress, science groups, and planetary-exploration lobbies. In addition, the origins of New Horizons reveal how contingent the emergence of a particular space science mission can be.
A heterozygous frameshift mutation in exon 1 of CDKN1B gene in a patient affected by MEN4 syndrome
Authors: Tonelli Francesco , Giudici Francesco , Giusti Francesca , Marini Francesca , Cianferotti Luisella , Nesi Gabriella , Brandi Maria Luisa
Published: May 2014

Objective

Multiple endocrine neoplasia type 4 (MEN4) is an autosomal dominant disorder that presents with a spectrum of clinical manifestations overlapping with those of MEN1 syndrome. It is caused by inactivating mutations of the CDKN1B gene, encoding for p27kip1 cyclin-dependent kinase 2 inhibitor, implicated in cell cycle control. Eight mutations of CDKN1B in MEN4 patients have been published so far. The aim of this study was to characterize the molecular basis of a case of MEN1-like syndrome with a neuroendocrine tumor and persistent primary hyperparathyroidism (PHPT).

Methods

Clinical, biochemical, and genetic evaluation were undertaken in the proband (a 53-year-old Caucasian woman) and in one 34-year-old son. The proband was operated for recurrent PHPT. Sequence analysis of the MEN1 and CDKN1B genes was performed on constitutional and parathyroid tissue DNA. Staining for p27 was carried out in parathyroid tissue.

Results

Neither MEN1 mutations nor large deletions encompassing the MEN1 gene on chromosome 11q13.1 could be detected in the proband. A germline frameshift mutation of CDKN1B (371delCT) was revealed, predicted to generate a truncated p27 (CDKN1B) protein. This mutation was confirmed on somatic DNA from the pathological parathyroid tissue, with the retention of the WT allele.

Conclusions

We report a germline heterozygote frameshift mutation of the CDKN1B gene in a Caucasian woman with a long clinical history of MEN1-like multiple endocrine tumors, along with the finding of the mutation in her son. This is the first report of positive CDKN1B mutation analysis in a male subject and also the first description of recurrent hyperparathyroidism in MEN4.
Relaxin receptor antagonist AT-001 synergizes with docetaxel in androgen-independent prostate xenografts
Authors: Neschadim Anton , Pritzker Laura B , Pritzker Kenneth P H , Branch Donald R , Summerlee Alastair J S , Trachtenberg John , Silvertown Joshua D
Published: May 2014

Androgen hormones and the androgen receptor (AR) pathway are the main targets of anti-hormonal therapies for prostate cancer. However, resistance inevitably develops to treatments aimed at the AR pathway resulting in androgen-independent or hormone-refractory prostate cancer (HRPC). Therefore, there is a significant unmet need for new, non-androgen anti-hormonal strategies for the management of prostate cancer. We demonstrate that a relaxin hormone receptor antagonist, AT-001, an analog of human H2 relaxin, represents a first-in-class anti-hormonal candidate treatment designed to significantly curtail the growth of androgen-independent human prostate tumor xenografts. Chemically synthesized AT-001, administered subcutaneously, suppressed PC3 xenograft growth by up to 60%. AT-001 also synergized with docetaxel, standard first-line chemotherapy for HRPC, to suppress tumor growth by more than 98% in PC3 xenografts via a mechanism involving the downregulation of hypoxia-inducible factor 1 alpha and the hypoxia-induced response. Our data support developing AT-001 for clinical use as an anti-relaxin hormonal therapy for advanced prostate cancer.
Targeting estrogen receptor subtypes (ERα and ERβ) with selective ER modulators in ovarian cancer
Authors: Chan Karen Kar-Loen , Leung Thomas Ho-Yin , Chan David Wai , Wei Na , Lau Grace Tak-Yi , Liu Stephanie Si , Siu Michelle K-Y , Ngan Hextan Yuen-Sheung
Published: May 2014

Ovarian cancer cells express both estrogen receptor α (ERα) and ERβ, and hormonal therapy is an attractive treatment option because of its relatively few side effects. However, estrogen was previously shown to have opposite effects in tumors expressing ERα compared with ERβ, indicating that the two receptor subtypes may have opposing effects. This may explain the modest response to nonselective estrogen inhibition in clinical practice. In this study, we aimed to investigate the effect of selectively targeting each ER subtype on ovarian cancer growth. Ovarian cancer cell lines SKOV3 and OV2008, expressing both ER subtypes, were treated with highly selective ER modulators. Sodium 3′-(1-(phenylaminocarbonyl)-3,4-tetrazolium)-bis(4-methoxy-6-nitro) benzene sulfonic acid hydrate (XTT) assay revealed that treatment with 1,3-bis(4-hydroxyphenyl)-4-methyl-5-[4-(2-piperidinylethoxy)phenol]-1H-pyrazole dihydrochloride (MPP) (ERα antagonist) or 2,3-bis(4-hydroxy-phenyl)-propionitrile (DPN) (ERβ agonist) significantly suppressed cell growth in both cell lines. In contrast, 4,4′,4″-(4-propyl-[1H]-pyrazole-1,3,5-triyl) trisphenol (PPT) (ERα agonist) or 4-[2-phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]-pyrimidin-3-yl]phenol (PHTPP) (ERβ antagonist) significantly enhanced cell growth. These results were confirmed on a xenograft model where SKOV3 cells were injected s.c. into ovariectomized mice. We observed that the average size of xenografts in both the DPN-treated group and the MPP-treated group was significantly smaller than that for the vehicle-treated group. In addition, we found that phospho-AKT expressions in SKOV3 cells were reduced by 80% after treatment with MPP and DPN, indicating that the AKT pathway was involved. The combined treatment with MPP and DPN had a synergistic effect in suppressing ovarian cancer cell growth. Our findings indicate that targeting ER subtypes may enhance the response to hormonal treatment in women with ovarian cancer.