bluuebunny/crossref_metadata_2025 huggingface dataset:
Baroreceptor-Inspired Microneedle Skin Patch for Pressure-Controlled Drug Release
Authors: He Jiahui , Zheng Mengjia , Hu Tianli , Huang Ya , Su Jingyou , Zhi Chunyi , Yu Xinge , Xu Chenjie
Published: April 2024

Objective
: We have developed a baroreceptor-inspired microneedle skin patch for pressure-controlled drug release.
Impact Statement
: This design is inspired by the skin baroreceptors, which are mechanosensitive elements of the peripheral nervous system. We adopt the finger touching to trigger the electric stimulation, ensuring a fast-response and user-friendly administration with potentially minimal off-target effects.
Introduction
: Chronic skin diseases bring about large, recurrent skin damage and often require convenient and timely transdermal treatment. Traditional methods lack spatiotemporal controllable dosage, leaving a risk of skin irritation or drug resistance issues.
Methods
: The patch consists of drug-containing microneedles and stretchable electrode array. The electrode array, integrated with the piezoconductive switch and flexible battery, provides a mild electric current only at the spot that is pressed. Drugs in microneedles will then flow along the current into the skin tissues. The stretchable feature also provides the mechanical robustness and electric stability of the device on large skin area.
Results
: This device delivers Cy3 dye in pig skin with spatiotemporally controlled dosage, showing ~8 times higher fluorescence intensity than the passive delivery. We also deliver insulin and observe the reduction of the blood glucose level in the mouse model upon pressing. Compared with passive delivery without pressing, the dosage of drugs released by the simulation is 2.83 times higher.
Conclusion
: This baroreceptor-inspired microneedle skin patch acts as a good example of the biomimicking microneedle device in the precise control of the drug release profile at the spatiotemporal resolution.
Towards the Emergence and Valorization of Necessity Entrepreneurship: The Case of Women in the Republic of Congo
Authors: Koulounda Dr. Aimée Tathiana , Favre Dr. Jean-Paul
Published: April 2024

This article sheds light on the specificities of necessity entrepreneurship, characterized by the concern to reduce the risk of sinking and disappearing, in contrast to opportunity entrepreneurship, which is based on a secure present and the willingness to take risks for a promising future. It examines the emergence and valorization of necessity entrepreneurship, with a focus on the case of women in the Republic of Congo. The article highlights key issues related to this form of entrepreneurship.
Role of Motivation in Employee Retention: A Study on Ready made Garments Manufacturing Company in Bangladesh
Authors: Miah Md Shahin
Published: April 2024

The objective of this research is to assess the influence of motivation on employee retention within the Ready made garments sector of Bangladesh. During the study, a customized questionnaire was formulated to conduct a survey. A total of 72 participants from various garments companies were surveyed. The research utilized statistical techniques including reliability analysis, validity analysis, correlation and regression analysis to scrutinize the collected survey data. The analysis was performed using statistical software SPSS version -20. The results of the study indicate that factors contributing to motivation, such as compensation, work-life-balance, job environment, supervisor-subordinate relationships, attractive salary and wages, supervision, working hours and both extrinsic and intrinsic benefits exert a substantial impact on the ability to retain employees within Bangladesh’s Ready made Garments Industry.
The impact of the size of the training set on the predictive abilities of neural models on the example of the Day-Ahead Market System of TGE S.A.
Authors: Ruciński Dariusz
Published: April 2024

The main object of the research was to examine the acceptable time horizon that could be predicted by previously learned models of the Day-Ahead Market (DAM) TGE S.A. system. The article contains the results of research on the predicting ability of different ANN models of the DAM TGE S.A. The research was conducted based on data covering the operation of the Polish stock exchange in the period from 2002 to 2019 (the first half of the year). The research was carried out based on the learned ANN models of the DAM system. Data were taken for examination covering the time from 2002 to 2019 (1st half of the year) and was divided into a different period, i.e., a month, a quarter, and a half-year. , year, etc. The MSE, MAE, MAPE, and R2 were adopted as the criteria for assessing the ability of individual models to predict electricity prices. The research was carried out by successively expanding forecasting periods in a rolling manner. For example, for a half-year, prediction time intervals were increased from one week to month, two months, quarter, half-year, etc. results for a model representing a given period. A lot of interesting research results were obtained.
WPad BVI - a multilingual universal knowledge exchange tool with support for visually impaired users
Authors: Mikułowski Dariusz , Svetsky Stefan , Misota Branislav
Published: April 2024

Nowadays, users need to work simultaneously with many files and folders on their computer and various resources on the Internet, including several software pieces. It means that they have many windows open simultaneously, and they must continuously switch between different opened applications such as web browsers, text editors, or audio-visual programs. These problems are also crucial to blind or visually impaired users, for whom this issue is even more difficult. Due to the nature of their work, i.e., they do not use the mouse and cannot see the video and graphic content, they have to remember, at each moment, which programs they have open and which they no longer use. In this paper, we propose an approach that consists of universal software, where, on the one hand, the user can collect and view data; on the other hand, he can produce ready-made output packages in simple web pages. This solution consists of two main parts: an offline softwareWPad and the online - Personal Knowledge Information System (PIKS). We propose a simplified and more automated version of an earlier developed WPad software system called WPad for BVI, which visually impaired persons and other beginners can use. The solution was tested by two BVI users (one BVI student and one BVI teacher) and several non-disabled teachers and students from Poland and Slovakia. Feedback from users was collected that will be used to improve the system further.
El rol de la academia en la lucha contra el Dengue
Authors: Ybaseta-Medina Jorge , Becerra Canales Bladimir , Hernández-Huaripaucar Edgar
Published: April 2024

En el Perú, se enfrenta un aumento alarmante en los casos de dengue, con un registro de 24,981 afectados, que significa un incremento del 97.9% en comparación al mismo periodo del año anterior, según el Ministerio de Salud (1). Este aumento no solo refleja una creciente preocupación por la salud pública sino también una llamada urgente a la acción, especialmente para las instituciones educativas como las universidades, que se encuentran en una posición privilegiada para intervenir eficazmente en esta crisis.
La academia con su vasto recurso intelectual y comunidades comprometidas, tienen el potencial de ser catalizadores en la prevención y el control del dengue. Su capacidad para generar investigación aplicada, innovación y conocimiento especializado les permite desarrollar estrategias específicas y contextualizadas que pueden jugar un papel crucial en la mitigación de esta enfermedad vectorial (2).
Diseño organizacional de un departamento académico de la facultad de medicina con una carrera profesional de 4 áreas distintas
Authors: Trinidad López Jesús Martín , Muñoz Zambrano María Elena , Camacho-Conchucos Herminio Teófilo
Published: April 2024

El artículo aborda la importancia del diseño organizacional en el Departamento Académico de Tecnología Médica de la Facultad de Medicina de la Universidad Nacional Mayor de San Marcos ubicada en la Av. Grau en Lima, Perú. Destaca la relevancia de la gestión eficiente para lograr la acreditación de la Escuela de Tecnología Médica, explorando sus cuatro áreas distintas. La contextualización incluye el análisis de indicadores en la docencia universitaria, principios organizacionales en universidades públicas y criterios para el diseño organizacional. Las experiencias en la gestión administrativa se centran en el liderazgo, la calidad en la docencia universitaria y los niveles de impacto de los departamentos en la mejora de la calidad. Finalmente, se propone un sistema de gestión basado en el ciclo de Deming y el proceso de autoevaluación para alcanzar la acreditación y mejorar continuamente la calidad educativa.
PARAMETER CALIBRATION AND DISCRETE ELEMENT MODEL OF HIGHLAND BARLEY STEM BASED ON EDEM
Authors: JIN Fan , LIU Dejiang , ZHONG Chengyi , YAO Keheng , TONG Jian , JIANG Zhibing
Published: April 2024

In view of the lack of accurate contact parameters and the difficulty of measuring contact parameters in the discrete element simulation of mechanized harvesting of highland barley, this study took the wax-ripening highland barley as the object, carried out the discrete element simulation of highland barley stem based on EDEM, and calibrated the discrete element simulation parameters of highland barley stem by response surface optimization. In this paper, Plackett-Burman test was used to screen 8 initial parameters. It was found that the static friction coefficient between highland barley stems, the rolling friction coefficient between highland barley stems, and the rolling friction coefficient between highland barley stems and steel plates have significant effects on the particle angle of repose. Based on the optimal value range of significant factors determined by the steepest ascent test, a second-order regression model of the angle of repose and significant parameters was established and optimized based on the results of Box-Behnken test. The optimal parameter combination of significant parameters was obtained as follows: static friction coefficient between highland barley stems is 0.27, rolling friction coefficient between highland barley stems is 0.07, and rolling friction coefficient between highland barley stems and steel is 0.26. Finally, the simulation results under the optimal parameter combination are compared with the actual test angle of repose. The relative error is 0.52 %. That indicates that the parameters of the simulation calibration are credible, which can provide a reference for the future research on the cleaning device in the mechanized harvesting of highland barley.
Application of RFSoC-based arbitrary waveform generator for coherent control of atomic qubits
Authors: Maetani Kazunori , Machino Akinori , Koike Keisuke , Morisaka Shinichi , Miyanishi Koichiro , Kobayashi Toshiki , Toyoda Kenji , Negoro Makoto , Miyoshi Takefumi , Ohira Ryutaro
Published: April 2024

This study evaluates an AMD Zynq Ultrascale+ RF System-on-Chip (RFSoC) as an arbitrary waveform generator (AWG) for controlling atomic qubits coherently. We explore the advantages of using an RFSoC-based AWG for atomic qubit manipulation and experimentally demonstrate its utility in quantum computing. Our findings demonstrate that RFSoC is a scalable solution for developing large-scale quantum computers with atomic qubits, offering a promising approach for applications.
Improvement of photothermal heating efficiency of Si plasmonic waveguide heaters with ring resonators
Authors: Shimizu Hiromasa , Shinohara Kota , Hasumi Masahiko
Published: April 2024

We report improved photothermal heating efficiency of Si plasmonic waveguide heaters integrated with ring resonators by enhancing the interaction of the propagating light and metal with a thinner buffer layer. The resonance wavelength was shifted towards a longer wavelength by inputting transverse magnetic mode light, and the amount of shift was influenced by the length of the region deposited with the Co thin film and the gap of the directional coupler. The local temperature rise of 580 K was achieved by injecting 6.3 mW of light, and photothermal conversion efficiency as high as 106 K mW−1 was obtained in a Si plasmonic waveguide deposited with 0.5 μm long Co thin films, showing improvement compared with previous devices. Discussion on the heating efficiency based on the propagation loss and cavity loss in the ring resonators is given based on experimental results, to realize compact photothermal waveguide heaters for various applications.
HUBUNGAN STUNTING DENGAN PERKEMBANGAN MOTORIK PADA
ANAK BAWAH LIMA TAHUN DI PUSKESMAS KALIRUNGKUT SURABAYA
Authors: Wiyono Chenny A , Herliani Olivia , Suhartati Suhartati , Indahsari Noer Kumala , Masfufatun Masfufatun
Published: April 2024

Menurut data World Health Organization (WHO) angka kejadian stanting pada anak usia dibawah 5 tahun (balita) merupakan yang tertinggi di dunia selama 10 tahun terakhir (2010–2020) di wilayah Asia Tenggara. Persentase angka kejadian stunting di Indonesia juga masih tinggi yaitu 21,6% pada tahun 2022. Penelitian ini bertujuan untuk mengetahui hubungan stunting dengan perkembangan kemampuan motorik kasar dan halus pada anak balita. Penelitian ini menggunakan metode deskriptif analitik dengan pendekatan cross sectional. Populasi pada penelitian ini adalah semua anak balita di Puskesmas Kalirungkut Surabaya. Metode pengambilan sampel dilakukan dengan teknik random sampling. Jumlah sampel yang didapat dalam penelitian ini sebanyak 30 anak balita normal dan 30 anak balita stunting. Uji statistik yang digunakan adalah Chi Square. Hasil penelitian menunjukkan ada hubungan antara stunting dengan perkembangan motorik kasar dan motorik halus. Tambahan hasil uji statistik juga mengindikasikan adanya hubungan antara stunting dengan perkembangan balita dengan nilai p = 0,001 (α < 0,05) dan ada hubungan antara stunting dengan perkembangan sosialisasi dan kemandirian dengan nilai p = 0,009 (α < 0,05), namun tidak terdapat hubungan antara stunting dengan perkembangan bicara dan bahasa dengan nilai p = 0,592 (α > 0,05). Kesimpulan dari penelitian ini bahwa keadaan stunting pada anak balita menghambat perkembangan motorik kasar dan halus. Adanya gangguan dalam perkembangan motorik balita akan mengurangi kemampuannya untuk mandiri dan beraktivitas, termasuk bermain, sehingga dapat pula menghambat perkembangan otak, tubuh, kemampuan berkomunikasi dan bersosialisasi. Intervensi sedini mungkin seperti perbaikan asupan gizi harian dan stimulasi motorik sangat penting untuk dilakukan. Intervensi dini ini diharapkan dapat mencegah kehilangan potensial dan memperbaiki tumbuh kembang anak.
Kata kunci: balita, perkembangan motorik, stunting
TELAAH PUSTAKA: TROMBOSITOPENIA PADA PASIEN LEPTOSPIROSIS
Authors: Fanani Reza
Published: April 2024

Leptospirosis adalah penyakit zoonosis bakterial yang disebabkan oleh infeksi bakteri dari genus Leptospira yang patogen. Gambaran klinis penyakit ini bermacam-macam tergantung dari derajatnya, mulai dari demam, nyeri kepala, nyeri sendi, malaise, hingga gejala berat berupa pneumonia dan gagal ginjal yang disebut dengan sindrom Weil’s. Hasil pemeriksaan laboratorium yang dapat ditemukan salah satunya adalah trombositopenia. Telaah pustaka ini menjelaskan tentang patogenesis leptospirosis dan hal-hal yang berkaitan dengan terjadinya trombositopenia pada penyakit leptospirosis, dengan menggunakan data dari jurnal-jurnal elektronik yang didapat melalui search engine PubMed. Trombositopenia (trombosit < 150 x 109/L) erat kaitannya dengan Leptospirosis yang berat. Faktor-faktor yang berhubungan dengan trombositopenia yaitu stres oksidatif, kadar ikatan trombosit-VWF, serta beberapa temuan laboratorium yang buruk seperti hipoalbuminemia, kadar hemoglobin rendah, sera peningkatan kadar AST dan bilirubin total.

Kata kunci: leptospirosis, sindrom Weil’s, trombositopenia
Contribution to knowledge of the distribution of Noctuoidea (Insecta: Lepidoptera) in Ukraine
Authors: Geryak Yu. M. , Bezuglyi S. K. , Gera A. A. , Gleba V. M. , Ivaniy S. V. , Kanarskyi Yu. V. , Kavurka V. V. V. V. , Khalaim Ye. V. , Kovalchuk D. O. , Leshchenko M. V. , Sergienko V. M. V. M. , Suchkov S. I. , Trotsenko S. M. , Tsykal S. V. , Voronov V. K.
Published: April 2024

New records of 180 species of Noctuoidea from Ukraine are provided. Among them, one species, Hypenodes pannonica, is reported for the first time for Ukraine, and many species are recorded for the first time in certain regions: 92 — in Kirovograd Region, 13 — in Khmelnytskyi Region, 3 each — in Kharkiv and Poltava regions, 2 each — in Chernihiv, Lviv, and Rivne regions, and 1 each — in Cherkasy, Kyiv, Mykolaiv and Vinnytsia regions. In addition, new records for several local, rare and little-known species, with a distribution still insufficiently studied in Ukraine are presented. 1 fig., 18 refs.
HYPERPIGMENTATION SYNDROME
Authors: Shanil P Mohammed , Jasmin K Farsana
Published: April 2024

APS type 1 (APS-1) is a rare, autosomal recessive inherited disorder encompassing chronic mucocutaneous candidiasis, hypoparathyroidism, and
autoimmune adrenal insufciency, with the presence of two of these being essential for diagnosis.APS-1 primarily affects young patients, both
males and females equally. The pathogenesis of the syndrome involves the development of T cells with a high afnity to auto antigens; a defect in
the body's immune system fails to eliminate these T cells, and thus they bind to and attack the host's cells. Apart from the manifestations listed
above, APS-1 patients can also develop hypogonadism, vitiligo, chronic diarrhea and gastritis, autoimmune hepatitis, autoimmune
hypothyroidism, type 1 diabetes mellitus, and pituitary failure
PULPOTOMY IN MATURE PERMANENT TEETH WITH MTA :18 MONTH FOLLOW UP CASE SERIES
Authors: Talsania Viraj N. , M. Ujariya Urvashi , K. Kothari Anjali
Published: April 2024

The main emphasis in endodontics is shifting towards vital pulp therapy. Mineral trioxide aggregate (MTA) is one of the rst introduced
biocompatible bioactive cements that was recommended as a pulpotomy agent. This case report will help clinicians know clinical standard
operating protocols to follow for complete pulpotomy procedure using MTA and its outcome with 18-month follow up. MTA can be considered as
an effective and affordable alternative to root canal treatment in mature permanent tooth with carious pulp exposures.
INTRA-ABDOMINAL DISSEMINATED HYDATID CYST: A SINGLE TERTIARY CENTRE BASED OBSERVATIONAL STUDY
Authors: Guha Kushankur , Jana Arunava
Published: April 2024

Background: Abdominal disseminated hydatid cyst disease or Abdominal Hydatidosis is a zoonotic disease caused by a tapeworm Echinococcus
granulosus. Most common site affected in abdomen is liver, but it can affect any part of the body. It can be primary or secondary; primary
disseminated intra-abdominal Hydatidosis is rare, accounting 2% of all intraabdominal cysts.Objective: Determine the demographic variations,
presentation patterns, radiological staging, types of surgical management and outcomes of patients operated for intra-abdominal hydatid cyst
(IAHC).Methodology: Aprospective descriptive study of patients admitted and operated for abdominal Hydatidosis of 11 cases.Results: Eleven
patients whose mean age is 36.9 years were operated for IAHC. Females (72.7%) were mostly affected. Commonest presenting symptom was
abdominal pain (90.9%). History of contact with dog was in nine patients (81.8%). Ultrasonography of whole abdomen and Contrast CT scan of
whole abdomen were main imaging studies done on 11(100%) and 8 (72.7%) patients, respectively. Cysts measuring more than 10cm were most
common ndings in both imaging. Liver is primary site of involvement, 9 (81.8%) cases. Seven patients (63.6%) underwent deroong, evacuation,
marsupialization and omentoplasty (DEMO). There was no recurrence, but 4 (36.4%) patients faced post-operative complications.Conclusion:
Early diagnosis and avoidance from pets should be done as it may occur anywhere of body. USG and CT remain preferred imaging. DEMO was
most common surgery
FUNGAL KERATITIS PRESENTING AS PIGMENTED CORNEAL PLAQUE: AN UNUSUAL CASE
Authors: Singla Brijesh , Bhatti Anubha , Singh Karamjit , Kaur Manveen , Kaur Divjot
Published: April 2024

To report the clinical ndings, laboratory ndings and treatment of an unusual case of pigmented fungal corneal ulcer. A 45 year old male presented
with history of an unknown insect falling into his left eye while driving. On examination, a paracentral brownish-black pigmented plaque of size
5mm x 5mm with surrounding inltrates was seen. The patient was treated with intrastromal injection of Voriconazole 50 mcg/0.1 ml, topical
Natamycin 5%, topical Voriconazole 1%, debridement and supportive therapy in the form of atropine 1% eye drops, topical antibiotics and oral
analgesics. The patient responded well to treatment.
COMPARATIVE EVALUATION OF THE EFFECT OF REMINERALIZING AGENTS ON THE SURFACE MICROHARDNESS OF BLEACHED ENAMEL: AN IN VITRO STUDY
Authors: Choudhari Prachi , Shenoi Pratima , Kubde Rajesh , Badole Gautam , Gunwal Mohit , Shahu Shriya
Published: April 2024

Aim and background: Patients seek cosmetic dentistry care for the elimination of any and all perceptions of discoloration in their teeth. Tooth
bleaching is one of the most frequently used cosmetic dental treatments to improve the appearance of discolored teeth. Vital tooth bleaching is used
for the removal of extrinsic stains due to tea, coffee, and tobacco etc. Bleaching chemicals cause a decrease in enamel microhardness due to the
oxidation and reduction processes, which disintegrate organic and inorganic tooth components (demineralization). Studies have proven that
remineralization treatments with a remineralizing agent are capable of reestablishing lost enamel surface's hardness and alterations caused by
dental bleaching. In the present study, changes in microhardness are analyzed upon the application of a remineralizing agent after subjecting the
enamel surfaces to bleaching. Aim of the study is to evaluate the surface microhardness of bleached enamel after treating with Calcium sucrose
phosphate (Toothmin), and CPP-ACP (GC Tooth mousse). Twenty six freshly extracted, sound premolars w Methods: ere collected and their roots
were removed. Samples were divided into two experimental groups; n=13 (Group 1for Tooth mousse and 2 for Toothmin). Microhardness was
measured at baseline and after bleaching and remineralization. The application of bleaching agents r Results: esulted in a signicant decrease in
enamel microhardness as compared to baseline. The application of remineralizing agents signicantly recovered the initial microhardness of the
enamel as before bleaching treatment. The recovery of surface microhardness after remineralization was signicantly greater in Group 2
(Toothmin) as compared to Group 1 (CPP-ACP) (p<0.05). Tooth mousse and Toothmin both are efcient in Conclusion: reestablishing surface
microhardness of enamel which decreased after vital bleaching. Comparatively, Toothmin showed more potential for restoring surface
microhardness than Tooth mousse.
A STUDY ON WEAK D PREVALENCE AMONG BLOOD DONORS AND PATIENTS AT TERTIARY CARE REFERRAL HOSPITAL IN BHAVNAGAR, GUJARAT
Authors: Chauhan Nisha , Chavda Jitendra , Bukeliya Nirmeet
Published: April 2024

Background: Rh blood group system is one of the most important as well as highly immunogenic and complex with numerous polymorphisms.
Our study is designed to determine the frequency of weak D antigen in donors and patients coming to our tertiary care hospital which is important
when labelling the donor and patient as the donor is labelled D positive and patient as D negative. Material and method: All blood donors and
patient's samples were tested for ABO and RhD using anti-D IgM monoclonal and a blend anti-D IgM and IgG reagents. The blood samples which
were negative for agglutination by immediate spin method were further tested for weak D using IgG anti-D in the IATphase with LISS/Coomb's gel
card. Result: A total 31778 blood samples were tested (17634 donors, 14144 patients) during the period January 2021 to December 2021.Among
these 29755 were Rh D positive (93.63%) and remaining 2023(6.36%) were Rh D negative. Atotal of 09 were weak D positive constituting 0.44%
of Rh D negative and 0.028 % of total samples received. Conclusion: It is mandatory to perform weak D testing routinely in donors as well as
patients who are negative with saline anti-D, to prevent alloimmunization and for labelling of donors and patients.
NEUROENDOCRINE NEOPLASMS: RETROSPECTIVE CLINICOPATHOLOGIC STUDY IN TERTIARY HOSPITAL
Authors: Vissa Shanthi , Vulava Siva Kumar , Maduri Alekhya , Nandyala Rukmangadha , Shilpa Bindela , Rao Guthi Visweswara
Published: April 2024

Background: Neuroendocrine neoplasms are rare heterogenous tumors having common phenotype. They can be located in any organ and
originate from endodermal cells which proliferate from epithelium or other tissues with or without endocrine function. Aim: The objective of the
present study is to compare frequency, distribution, clinicopathological features and their prognostic importance in the neuroendocrine neoplasms.
Methodology: A retrospective hospital based study of the data was carried out for a period of 8 years from September 2015 to September 2023
after getting approval from institutional ethical committee. Clinicopathological data of Neuroendocrine neoplasms were collected by analyzing the
hospital records. Results: Our study included 147 cases of NENs. Incidence of NENs was slightly higher in males (53.7%) and in the age group
above 50 years (64.7%). Frequency of NENs were found to be highest in gastro intestinal tract (41 cases, 27.8%). Maximum number of NENs were
localized and tumors with distant metastasis were seen in small bowel. Grade 1 tumors were seen most commonly in stomach, small bowel,
pancreas and appendix. Maximum number of grade 2 tumors and grade 3 tumors were seen in stomach and liver. Neuroendocrine carcinomas were
seen commonly in lung. Tumors with distant metastasis were seen in grade 3 Neuroendocrine neoplasms and neuroendocrine carcinomas.
Conclusion: Male gender, elderly age and high grade were associated with worse prognosis. Gastrointestinal tract is the most common organ
involved and were of lower grade. Lung had highest incidence of high grade tumors, but distant metastasis were seen in tumors of small intestine.
EFFICACY OF VARIOUS OPTIONS FOR COVERAGE OF HEEL DEFECTS
Authors: Ghosh Homagni , Jash Prabir Kumar , Saha Debraj
Published: April 2024

Heel consists of a plantar surface and a posterior surface. Plantar heel defects present a challenging problem for reconstruction because
of lack of locally available tissues, the weight-bearing requirement of the region and the presence of glabrous skin. Posterior heel
defects on the other hand, present the challenge of requirement of gliding of the soft tissues over the tendoachilles. In this prospective
study conducted in a tertiary care centre from April 2020 to September 2021, 20 consecutive patients presenting with heel defects were
recruited. Thirteen of the patients presented with plantar heel defects while seven of the patients presented with posterior heel defects.
Medial plantar artery ap (N=6), reverse sural artery ap (N=5), peroneus brevis muscle ap (N=3 ), abductor hallucis myocutaneous
ap (N=3) and posterior tibial artery perforator ap (N=3) were used for resurfacing the heel defects. Although, the medial plantar
artery ap and the abductor hallucis myocutaneous ap were noted to be the best suited for plantar heel defects since these aps met
the requirements of the region of like tissue replacing like and the need of sensory innervation, the abductor hallucis myocutaneous
ap was found to be better in terms of the additional procedures required. On the other hand, the reverse sural artery ap and the
peroneus brevis muscle ap was noted to be the best suited for the posterior heel defects.
A CASE REPORT ON ULTRASOUND GUIDED NERVE BLOCKS IN A PATIENT WITH MOBILE LEFT VENTRICLE APICAL CLOT AND POOR EJECTION FRACTION FOR OPEN HERNIOPLASTY
Authors: Begum Shaik Ayesha , Kommineni Sowmya
Published: April 2024

It is challenging to administer anaesthesia in patients with poor ejection fraction. The presence of a left ventricular apical clot adds to the challenge.
We present a case of Right indirect inguinal hernia for open hernioplasty in a patient with an incarcerated hernia with poor ejection fraction and
mobile apical clot in left ventricle. Ultrasound guided multimodal nerve blocks with right paravertebral block T10-L2, right ilioinguinal, iliohypogastric and right genitofemoral nerve blocks were performed leading to good perioperative analgesia and smooth post operative outcome.
Regional anesthesia techniques provide the potential perioperative benets of stress response attenuation, shorter hospital stay, and intense
postoperative analgesia. Regional anaesthesia is not just limited to neuraxial techniques and it is a lot beyond that. Adding ultrasound approach to
the nerve blocks provides safe approach for the nerve blockade technique. In view of these benets we have used ultrasound guided nerve block
techniques like paravertebral block, ilioinguinal, iliohypogastric and genitofemoral nerve blocks for good perioperative analgesia and smooth post
operative outcome.
Socioeconomic determinants of credit need assessment of Fadama farmers in Delta State, Nigeria
Authors: Oratokhai R. A , Eweka K.I.
Published: April 2024

The study examined the credit need of farmers involved in Fadama III programme in the three agricultural zones of Delta State, Nigeria. Specifically examined the constraints faced by them as well as tested the relationship between the farmers’ socio-economic characteristics and their credit needs. Data was collected using the questionnaire method administered to 176 Fadama farmers and was subjected to descriptive statistics, Pearson Product Moment correlation analysis and analysis of variance. The Socio-economic characteristics of the respondents revealed that Fadama participants were young with mean age of 45 years. They were highly educated (91%) and having some form of formal education. The respondents were of 14 years farming experience and 50.1% of them were married and they were faced with problem of getting credit facilities. It was found that both male and female farmers participated in the Fadama III programme. The average loan received by respondents from the Fadama III programme was N500,000. However, the desired credit volume by the respondents was about N920,000, suggesting a gap between what the farmers were given and what they actually needed. The coefficient of determination of the respondents at 0.05% shows that age (r = -0214), educational qualification (r = 0.180) and farming status (r = 0.157 correlated with their desired credit volume. The study concluded that Fadama III management should increase the volume of credit disbursed to the farmers and remove the bottlenecks in acquisition of credit
Studies on nutritional potentials of Anacardium occidentale (Cashew) leaf as off season feed for ruminants in the humid tropics
Authors: Mako A. A. , Ettu R.O , Olaleye D. J.
Published: April 2024

This study was designed to investigate the nutritional potential of Anarcardium occidentale leaf (AOL) as off season feed for ruminants. Two studies were conducted; the first study involves evaluation of the nutrient, mineral and anti-nutrient content of green, yellow and brown AOL while the second study involves the in vitro gas production (IVGP) of AOL which was carried out over a period of 24 hr incubation to predict Metabolizable energy (ME), organic matter digestibility (OMD) and short chain fatty acids (SCFA). Methane (CH4) was measured by introducing 10 M NaOH into the inoculums after incubation. Results revealed significant (p<0.05) differences in the values of the nutrient composition. The dry matter ranged between 89.68% and 90.91% in green and brown leaf respectively. The highest crude protein (17.44%) was obtained in green leaf, while the lowest (16.06%) was recorded for brown leaf. The mineral and anti-nutrient content of AOL were not significantly different from each other, but within acceptable limit for optimum metabolism. The total IVGP varied significantly (p< 0.05) with the green leaf recording the highest (16.00ml) value, while the lowest (7.00ml) value was obtained in brown leaf. Same trend was observed for IVGP parameter and characteristics, with green leaf recording the highest values, while the lowest values were obtain from brown leaf for all parameters measured). It can be concluded that AOL has potential in livestock nutrition. Also the problem associated with disposal of falling brown leaf can be conveniently reduced by incorporating them into ruminant feed.
Milk yield and composition of West African dwarf (wad) goats fed palm kernel cake supplement for conventional concentrate
Authors: Olawoye S.O. , Okeniyi F.A , Adeloye A.A , Alabi O.O , Shoyombo A.J , Animashahun R. A. , Yousuf M. B
Published: April 2024

The effect of replacement of conventional Concentrate (CC) supplement with Palm Kernel Cake (PKC) on the milk composition and yield of West African Dwarf (WAD) dams fed Pennisetum purpureum silage (grass) basal ration was investigated. Twenty five lactating WAD dams of average weight of 13kg ± 0.2 were randomly assigned into five dietary treatments in a Completely Randomized Design (CRD) layout. Each treatment group consists of five replicates of lactating dam. Dams were individually housed and offered silage freely with 400g of one of the five supplement treatments (T) per day ( viz: C/PKC: T1 – T5); T1: 100/0; T2: 75/25; T3: 50/50; T4: 25/75 and T5: 0/100). The replacement of CC by PKC had significant (p<0.05) effect on the average milk yield, percentage (%) fat, protein, specific gravity, ash and fat corrected milk (FCM) but showed no significant (p>0.05) effect on the total solid (TS%) of the milk of the treatments. Based on this result it can be concluded that the proportionate combinations of CC and PKC as supplement to Pennisetum purpureum (grass) silage rations of WAD goats during lactation will improve the milk yield and the composition without adverse effect. However, at 50% replacement of CC by PKC (50/50) the milk yield is enhanced while the fat and protein components were improved at 100% replacement of CC by PKC.
De meerwaarde van psychosociale therapie in een veranderende ggz
Authors: Heezius Cindy , van der Meulen Margit
Published: April 2024

De ggz staat onder druk: niet alleen zijn er wachtlijsten, ook ervaren professionals de werkdruk als te hoog. Intussen neemt de vraag naar specialistische ggz toe. Hoe houden we de ggz houdbaar en toegankelijk? In deze bijdrage wordt verkend hoe psychosociale therapie een rol kan spelen in de verandering van de ggz van diagnosegedreven zorg naar zorg die beter aansluit bij het functioneren in het dagelijks leven. Dit type zorg is laagdrempelig en kan naar de mening van de auteurs bijdragen aan verkorting van de wachtlijsten.
Eenzaamheid en autisme
Authors: Rieffe Carolien , Tsou Yung-Ting , Hooi Desiree , Delsink Elijah
Published: April 2024

Loneliness, defined as a mismatch between the desired and actual social connectedness, is a daily reality for many autistic people. Th is article highlights the complexities of loneliness and social connectedness, focusing on the perspectives of youth on the spectrum in the school context. School is the place where students meet and socialize. Yet, it is also where autistic students must process many stimuli, and often experience bullying, insults, misunderstanding, and ultimately loneliness. To build a school in which every student feels welcome and heard, and can develop optimally, the first step concerns the school environment. Many school environments are not sufficiently tailored to the diverse needs of autistic students, and other students who are not ‘mainstream’. Implicit values and norms are often applied in schools, which unintentionally disadvantage and exclude autistic students and promote stigmatization. Moreover, the physical environment of the school often makes it impossible for autistic students to socialize with fellow students when the need arises. Adjustments to school policy and architecture can contribute to an environment that is accessible, safe and pleasant for diverse students. Our research project ‘Build 4 Belonging’, which will start in 2024, focuses on the precondition for promoting equality of opportunity: an environment that is suitable for different types of students, based on individual wishes, needs and capabilities.
Lichaamsgerichte interventies bij autisme: een verkenning
Authors: Huberts Eline , Stapert Anne-Fleur , Veldman-Keers Jacqueline , van Wensen Carla , Greaves-Lord Kirstin
Published: April 2024

People with an autism spectrum disorder (ASD) regularly struggle with issues in sensory processing, interoception, and self-regulation. This can contribute to the development of anxiety, depression, and burnout. Moreover, there is an overlap in the symptomatology of ASD and post-traumatic stress disorder (PTSD) (Stavropoulos et al., 2018). This is of note because body-oriented interventions that show effects on trauma in clinical practice could potentially be useful for people with autism. The current essay discusses two interventions focused on the body that could promote mental well-being in people with autism: sensorimotor psychotherapy (SP) and Somatic Experiencing® (SE). The interventions are possibly useful as part of integrated care for people with autism. However, they probably require adaptations to better suit those with autism. We describe two cases to illustrate how body-oriented interventions are used in different ways in clinical practice. We end with a call to bridge the gap between theory and clinical practice, through sharing knowledge and experiences and the furthering of scientific research into body-focused interventions that are already being used in clinical practice.
Impact of Pre-existing Type 2 Diabetes Mellitus and Cardiovascular Disease on Healthcare Resource Utilization and Costs in Patients With COVID-19
Authors: Nguyen Chi , Crowe Christopher , Kuti Effie , Donato Bonnie , Djaraher Rachel , Seman Leo , Graeter Nancy , Power Thomas , Mehra Rinku , Willey Vincent
Published: April 2024

Background: The economic burden associated with type 2 diabetes mellitus (T2DM) and concurrent cardiovascular disease (CVD) among patients with COVID-19 is unclear. Objective: We compared healthcare resource utilization (HCRU) and costs in patients with COVID-19 and T2DM and CVD (T2DM + CVD), T2DM only, or neither T2DM nor CVD (T2DM/CVD). Methods: A retrospective observational study in COVID-19 patients using data from the Healthcare Integrated Research Database (HIRD®) was conducted. Patients with COVID-19 were identified between March 1, 2020, and May 31, 2021, and followed from first diagnosis or positive lab test to the end of health plan enrollment, end of study period, or death. Patients were assigned one of 3 cohorts: pre-existing T2DM+CVD, T2DM only, or neither T2DM/CVD. Propensity score matching and multivariable analyses were performed to control for differences in baseline characteristics. Study outcomes included all-cause and COVID-19–related HCRU and costs.
Incidência de novos casos de hanseníase na região Sudeste (2018-2023): Um estudo ecológico
Authors: Salaroli Robson , Ambrósio Marcos Flávio Spínola , Lordão Daniel Batista Monte Alto do Vale , Aguiar Lorena Louise Botelho de , Aguiar Thais Caroline Botelho de , Silva Fernanda Campolina Alves , Filho Glauber Pablo Soriano de Carvalho , Agostini Beatriz Montezano Oliveira , Soares Leonardo Ricardo , Martins Lívia Deziré , Martins Letícia Deziré , Rezende Larissa Pereira
Published: April 2024

A hanseníase é uma doença infecciosa crônica causada pela bactéria Mycobacterium leprae. Ela afeta principalmente a pele, os nervos periféricos, as mucosas das vias aéreas superiores e os olhos. A hanseníase é uma das doenças mais antigas da humanidade e, apesar dos avanços no seu tratamento, ainda representa um desafio de saúde pública em várias partes do mundo, especialmente em regiões tropicais e subtropicais. Este estudo ecológico busca analisar a incidência de novos casos da doença nos estados de São Paulo, Rio de Janeiro, Minas Gerais e Espírito Santo, durante entre os anos de 2018 a 2023. Para tal, utilizaram-se dados do Sistema de Informação de Agravos de Notificação (SINAN) do Departamento de Informática do Sistema Único de Saúde (DATASUS) para tabulação e analise do comportamento da doença na região. A análise abrangerá não apenas o número absoluto de casos, mas também taxa de incidência e prevalência por 100.000 habitantes, permitindo uma comparação mais precisa entre os estados analisados. Além disso, serão exploradas características sociodemográficas dos pacientes, como idade e  raça/etnia, a fim de identificar grupos de maior vulnerabilidade à doença. Desse modo,  este trabalho visa compreender a distribuição geográfica e temporal da hanseníase na região Sudeste no período avaliado, bem como identificar possíveis fatores associados ao aumento ou diminuição dos casos.
A relação entre climatério e distúrbios uroginecológicos
Authors: Caldeira ferraz borges Matheus , Da Silva Hotta Tiago , Sollitto Siqueira e Silva Bianca , Khaled Yassine Nesrin , Righi Bacchin Marina , Lagoa Pedroni Júlia , Tufani Alessandri Ítalo , Sales Fernandes do Carmo Henrique , Rezende Nóbrega Zamboni Giulia , Mariano Busano Enzo , Pimentel Sampaio Breno , Borges Credi Beatriz , Bento Gaia da Silva Beatriz , Menezes Thomaz Luiz Felipe , Gradella de Arruda Camargo Lorena , Drozdz Flavia , Teles Dornel Giovanna , Verrone Muniz dos Santos Marinna , Machado de Almeida Lucas , Bernardes Augusto Maria Fernanda
Published: April 2024

O climatério, marcado pela transição da fase reprodutiva para a não reprodutiva na vida da mulher, é um período que apresenta desafios significativos em termos de saúde uroginecológica. Distúrbios nesta esfera durante o climatério podem afetar a qualidade de vida das mulheres, exigindo uma compreensão aprofundada dos mecanismos subjacentes e das estratégias de manejo. Esta revisão integrativa busca explorar criticamente a literatura existente sobre a relação entre climatério e distúrbios uroginecológicos, fornecendo uma análise abrangente desses tópicos. A busca de artigos foi realizada em bases de dados relevantes, utilizando descritores específicos, como menopausa, climatério, distúrbios uroginecológicos, entre outros. Foram selecionados estudos que abordam os efeitos hormonais, manifestações clínicas e opções terapêuticas durante o climatério. As referências utilizadas nesta revisão foram selecionadas com base em sua relevância para o tema, conforme indicado na seção de referências. A análise dos estudos revela uma complexa interconexão entre o climatério e os distúrbios uroginecológicos. Evidências destacam alterações hormonais como fatores contribuintes para sintomas como incontinência urinária, atrofia vaginal e distúrbios do assoalho pélvico. Diferentes abordagens terapêuticas, desde intervenções hormonais até tratamentos não hormonais, foram exploradas na gestão desses distúrbios. Esta revisão integrativa oferece uma síntese abrangente da relação entre climatério e distúrbios uroginecológicos. Embora as evidências destaquem a influência dos fatores hormonais, a complexidade dessas interações sugere a necessidade de abordagens multidisciplinares na gestão clínica. A compreensão aprofundada dessas relações é crucial para orientar intervenções personalizadas e aprimorar a qualidade de vida das mulheres durante o climatério. Contudo, identificamos lacunas no conhecimento que ressaltam a necessidade de pesquisas futuras para melhor delineamento dessas interações e desenvolvimento de estratégias terapêuticas mais eficazes.
DESCRIPTION OF DEVELOPMENT CHILDREN AGE 24 – 59 MONTH
Authors: Tabah Hikmah Mesti , Widiasih Restuning , Ermiati Ermiati
Published: April 2024

Screening development for children is important to detected any developmental problem in children. Early detection in children development would provide early intervention if Wanaraja there are development problem. Therefore the aims of this study is to assess the development of children age 24 - 59 months This research was descriptive quantitative research, The sample in this study were 56 children age 24 – 59 month. The study was conducted in village, Karangpawitan sub-district, Garut city. The samples were choosen using consecutive sampling technique, and the data were collected with visit the posyandu.the Instrumen of this study was Kuisioner Pra-Skrining Perkembangan (Pre-Screening Development questionnare). The results showed that 60.7% of children development is normal, 30.4% doubting, and 8.9% have developmental problem. The conclusion, there are children in doubting and development problem category and need special attention. Recommendation, health workers is expected to provide further nursing intervention to children and parents especially for children with development problem.
Literary Analysis: Narrative Strategies and Cultural Implications in Cecilia Manguerra Brainard’s Short Stories
Authors: - Cris Al M. Cagoscos , - Rochelie D. Avenido , - Alona Jane P. Beriarmente , - Katherine Z. Estra , - Rica B. Jorillo , - Rodolfo A. Golbin Jr. , - Joxenne Jane A.  Tamarra
Published: April 2024

"The Flip Gothic" and "Woman with Horns" are two of the most influential and famous works of the Filipino-American author Cecilia Manguerra Brainard, containing different narrative strategies and cultural implications. This study examines these literary pieces using qualitative analysis as well as their interaction through analyzing their cultural meaning. The results showed that both short stories have a strong emphasis on tone and diction, while simple sentences appear to be more frequently used than other types of sentence structure. Moreover, there is a clear exposition of characters, plots, concepts, settings, conflicts, and foreshadowing; flashbacks, symbolism, and imagery are also visible. Likewise, Filipino cultural activities, such as the Sinulog festival, the belief in mythical creatures, and the practice of having ‘lechon’ on every occasion, are embodied in the stories as well. In conclusion, the author's writing styles and previous personal experiences have greatly influenced her way of writing. Therefore, the researchers recommend the development of a literary analysis resource that is both comprehensive and easily accessible, serving as a valuable reference for future researchers doing literary analysis studies.