bluuebunny/crossref_metadata_2025 huggingface dataset:
Management of subtrochanteric femur fractures: is open reduction associated with poor outcomes?
Authors: Panteli Michalis , Vun James Shen Hwa , West Robert Michael , Howard Anthony John , Pountos Ippokratis , Giannoudis Peter Vasilios
Published: November 2021

Purpose

The aim of this study was to identify factors associated with the need for open reduction in subtrochanteric femoral fractures and investigate the effect of cerclage wiring compared to open reduction alone, on the development of complications, especially infection and non-union.

Methods

All consecutive patients with a fracture involving the subtrochanteric region were retrospectively identified, over an 8-year period. Data documented and analysed included patient demographics, fracture characteristics, patient comorbidities, time to fracture union and development of complications.

Results

A total of 512 patients met the inclusion criteria (523 fractures). Open reduction was performed in 48% (247) of the fractures. Following matching and regression analysis, we identified diaphyseal extension of the fracture to be associated with an open reduction (OR: 2.30; 95% CI 1.45–3.65;p < 0.001). Open reduction was also associated with an increased risk of superficial infection (OR: 7.88; 95% CI 1.63–38.16;p = 0.010), transfusion within 48 h following surgery (OR: 2.44; 95% CI 1.96–4.87;p < 0.001) and a prolonged surgical time (OR: 3.09; 95% CI 1.96–4.87;p < 0.001). The risk of non-union, deep infection and overall mortality was not increased with open reduction. The use of cerclage wires [50 out of 201 fractures (24.9%) treated with an open reduction] to achieve anatomical reduction as compared to open reduction alone significantly reduced the risk of non-union (OR: 0.20; 95% CI 0.06–0.74;p = 0.015).

Conclusion

Open reduction of subtrochanteric fractures is not associated with an increased risk of deep infection and non-union, even though it is associated with an increased risk of superficial infection, prolonged surgical time and transfusion. The use of cerclage wire is associated with reduced risk of non-union with little evidence of an increase in complications.

Level of evidence

III.
Identification and characterization of a natural polymorphism in FT-A2 associated with increased number of grains per spike in wheat
Authors: Glenn Priscilla , Zhang Junli , Brown-Guedira Gina , DeWitt Noah , Cook Jason P. , Li Kun , Akhunov Eduard , Dubcovsky Jorge
Published: November 2021

Key message

We discovered a natural FT-A2 allele that increases grain number per spike in both pasta and bread wheat with limited effect on heading time.

Increases in wheat grain yield are necessary to meet future global food demands. A previous study showed that loss-of-function mutations in FLOWERING LOCUS T2 (FT2) increase spikelet number per spike (SNS), an important grain yield component. However, these mutations were also associated with reduced fertility, offsetting the beneficial effect of the increases in SNS on grain number. Here, we report a natural mutation resulting in an aspartic acid to alanine change at position 10 (D10A) associated with significant increases in SNS and no negative effects on fertility. Using a high-density genetic map, we delimited the SNS candidate region to a 5.2-Mb region on chromosome 3AS including 28 genes. Among them, only FT-A2 showed a non-synonymous polymorphism (D10A) present in two different populations segregating for the SNS QTL on chromosome arm 3AS. These results, together with the known effect of the ft-A2 mutations on SNS, suggest that variation in FT-A2 is the most likely cause of the observed differences in SNS. We validated the positive effects of the A10 allele on SNS, grain number, and grain yield per spike in near-isogenic tetraploid wheat lines and in an hexaploid winter wheat population. The A10 allele is present at very low frequency in durum wheat and at much higher frequency in hexaploid wheat, particularly in winter and fall-planted spring varieties. These results suggest that the FT-A2 A10 allele may be particularly useful for improving grain yield in durum wheat and fall-planted common wheat varieties.
The role of shuntography in diagnosis of mechanic complications after implantation of ventriculoperitoneal shunts in patients with idiopathic normal pressure hydrocephalus: a retrospective clinical evaluation
Authors: Rot Sergej , Goelz Leonie , Arndt Holger , Gutowski Pawel , Meier Ullrich , Lemcke Johannes
Published: November 2021

Background

Mechanical obstruction of ventriculoperitoneal shunt (VPS) during the first year after shunt implantation is a common complication and is widely described in the literature. In this paper, we evaluated the suitability of the shuntography for the diagnosis of mechanical complications of the VPS in patients with idiopathic normal pressure hydrocephalus (iNPH).

Methods

We retrospectively identified 49 patients with pathologic shuntography over of a period of 20 years in our hospital. The percentage of procedure-associated complications was determined.

Results

Ninety-eight percent (n = 48) of the patients who underwent shuntography showed clinical and radiographic signs of underdrainage prior to examination. Shuntography revealed mechanical complications of the VP shunt in 37% (n = 18) as a cause of clinical deterioration and following revision operation. During shuntography, mechanical obstruction was discovered in 78% (n = 14) and disconnection of shunt components in 22% (n = 4). In the obstruction group, in 50% (n = 7) the closure was detected in the ventricular catheter, in 29% (n = 4) in the distal catheter of the VPS, and in 21% (n = 3) in both sides of the VPS. In the case of an inconspicuous shuntography (63%, n = 31), the patients received symptomatic therapy (32%, n = 10) or re-adjustment of the valve setting (68%, n = 21). Fifty-seven percent of the patients who underwent surgical treatment improved clinically by at least one point according to the Kiefer score.

Conclusion

Shuntography can produce valuable clinical information uncovering mechanic complications after implantation VPS in patients with idiopathic normal-pressure hydrocephalus. Patients with mechanical complications of their VPS needed revision surgery and showed clinical benefit after treatment.
Einsatz von Biosimilars in der Behandlung der rheumatoiden Arthritis
Authors: Morf Harriet , Witte Thorben
Published: November 2021

In der Therapie der rheumatoiden Arthritis sind seit ca. 20 Jahren Biologika ein fester Bestandteil. Da Arzneimittelpatente in der Regel nach 10 Jahren auslaufen, wurden in den letzten Jahren Biosimilars auf den Markt gebracht. In vielen Studien konnte gezeigt werden, dass sie bei vergleichbarer Sicherheit und Effektivität eine gleichwertige Alternative zum Referenzarzneimittel darstellen. In manchen Fällen zeigten sich sogar geringere Raten an unerwünschten Arzneimittelwirkungen im Vergleich zu den Referenzarzneimitteln. Weiterhin können durch Biosimilars erhebliche Kosten eingespart werden, die sich allein in Deutschland auf einen jährlichen dreistelligen Millionenbetrag belaufen. Dabei lassen sich große regionale Unterschiede bei der Verschreibungshäufigkeit von Biosimilars in Deutschland ausmachen, die sich auch im Einsparungspotenzial widerspiegeln. Eine Umstellung auf ein Biosimilar ist unter Einbezug des Patienten gut möglich und auch erwünscht. In diesem Sinne ist auch die Erstverschreibung eines Biosimilars statt des Referenzarzneimittels zu befürworten.
Anxiety in women referred for colposcopy: a prospective observational study
Authors: Wittenborn Julia , Wagels Lisa , Kupec Tomas , Iborra Severine , Najjari Laila , Stickeler Elmar
Published: November 2021

Purpose

To evaluate the occurrence of anxiety in women attending a colposcopic examination within the new cervical cancer screening in Germany.

Methods

One hundred and fifty-six patients were asked to fill out Spielbergers STAI inventory form prior to their colposcopic examination. For the statistical analysis, a two by two between-group design was applied including the following group factors: the repeat factors included patients, who presented to our centre of dysplasia for the first time (new) and patients who have had an examination in our centre before (repeat). Further, the factor diagnosis included two groups: first, patients with cervical dysplasia and second, patients with vulva diseases.

Results

The analysis of the STAI results showed that patients presenting with cervical dysplasia for the first time had the highest levels of anxiety, directly followed by new patients in the vulva group. The ANOVA revealed a main effect of the repeat factor, F(1,140) = 7.53, p = 0.007. There was no significant effect of diagnosis.

Conclusion

Regardless of the diagnosis, patients being transferred for a colposcopy within the cervical cancer screening program for the first time have very high anxiety levels. The prospect of a potentially painful examination seems to be a key factor. Only a scientific evaluation of the new cervical cancer screening will be able to show if the rising numbers of colposcopic examinations is really worth the risk of exposing so many more women to the emotional distress of a colposcopy.
Die Unterwasserreinigung von Seeschiffen als Herausforderung für das Gewässerschutzrecht
Authors: Schatz Valentin J.
Published: November 2021

Dieser Beitrag knüpft thematisch an den in NuR 2021, 361ff. erschienenen Beitrag “Die
Regulierung der Einführung invasiver gebietsfremder Arten durch Biofouling an der Schnittstelle zwischen
Naturschutzrecht und Seeschifffahrtsrecht” an. Er widmet sich speziell den rechtlichen Rahmenbedingungen
der Unterwasserreinigung von Seeschiffen als einer Maßnahme des Biofouling Managements, die voraussichtlich
auch in Deutschland an Bedeutung gewinnen wird. Der Beitrag untersucht die Zulässigkeit der Unterwasserreinigung
aus Sicht des Gewässerschutzrechts im weiteren Sinne und zeigt, dass hierfür nicht das umweltbezogene
(Binnen-) oder Seeschifffahrtsrecht maßgeblich ist. Nach dem stattdessen ausschlaggebenden Wasserhaushalts-
und Meeresumweltrecht hängt die Zulässigkeit der Unterwasserreinigung von Seeschiffen davon ab,
ob bzw. wie gut die angewandte Methode bzw. Technologie in der Lage ist, die dabei freigesetzten Stoffe
aufzufangen und einer Verwertung oder Entsorgung an Land im Einklang mit dem Kreislaufwirtschaftsrecht zuzuführen.
50 Jahre Ramsar-Übereinkommen über Feuchtgebiete, insbesondere als Lebensraum für Wasser- und Watvögel, von internationaler Bedeutung – Eine Zwischenbilanz
Authors: Wormit Maximilian
Published: November 2021

Der Beitrag nimmt das 50-jährige Jubiläum des Ramsar-Übereinkommens zum Anlass, sein
wesentliches Regelungsprogramm einschließlich der dahinterstehenden Regelungsstrategie auszuleuchten.
Daran anknüpfend wird die Rezeption des Übereinkommens im europäischen und deutschen Naturschutzrecht
nachgezeichnet.
The Effect of Accelerated Ageing on Reaction-to-Fire Properties–Composite Materials
Authors: Sandinge Anna , Blomqvist Per , Sørensen Lars Schiøtt , Dederichs Anne
Published: November 2021

As material age, the durability, strength, and other mechanical properties are impacted. The lifespan of a material generally decreases when exposed to weathering conditions such as wind, temperature, humidity, and light. It is important to have knowledge of how materials age and how the material properties are affected. Regarding materials´ fire behaviour and the effect of ageing on these properties, the knowledge is limited. The research questions of the current work are: Are the fire properties of composite materials affected by ageing? And if so, how is it affected? The study is on material at Technology Readiness Level 9 (TRL). In this study, three composite fibre laminates developed for marine applications were exposed to accelerated ageing. Two different ageing conditions were selected, thermal ageing with an increased temperature of 90°C and moisture ageing in a moderately increased temperature of 40°C and a relative humidity of 90%. Samples were collected after one, two and four weeks of ageing. The reaction-to-fire properties after ageing was evaluated using the ISO 5660–1 cone calorimeter and the EN ISO 5659–2 smoke chamber with FTIR gas analysis. The test results showed that the fire behaviour was affected. Two of the composite laminates, both phenolic/basalt composites, showed a deteriorated fire behaviour from the thermal ageing and the third composite laminate, a PFA/glass fibre composite, showed an improved fire behaviour both for thermal and moisture ageing. The smoke toxicity was affected by the accelerated ageing, especially for the PFA/glass fibre composite that showed a higher production of CO and HCN, both for the thermal aged and the moisture aged samples.
Effect of central and peripheral cone- and rod-specific stimulation on the pupillary light reflex
Authors: Sonntag Anton , Kelbsch Carina , Jung Ronja , Wilhelm Helmut , Strasser Torsten , Peters Tobias , Stingl Krunoslav , Wilhelm Barbara
Published: November 2021

Purpose

To assess the effect of central and peripheral stimulation on the pupillary light reflex. The aim was to detect possible differences between cone- and rod-driven reactions.

Methods

Relative maximal pupil constriction amplitude (relMCA) and latency to constriction onset (latency) to cone- and rod-specific stimuli of 30 healthy participants (24 ± 5 years (standard deviation)) were measured using chromatic pupil campimetry. Cone- and rod-specific stimuli had different intensities and wavelengths according to the Standards in Pupillography. Five filled circles with radii of 3°, 5°, 10°, 20° and 40° and four rings with a constant outer radius of 40° and inner radii of 3°, 5°, 10° and 20° were used as stimuli.

Results

For cone-and rod-specific stimuli, relMCA increased with the stimulus area for both, circles and rings. However, increasing the area of a cone-specific ring by minimizing its inner radius with constant outer radius increased relMCA significantly stronger than the same did for a rod-specific ring. For cones and rods, a circle stimulus with a radius of 40° created a lower relMCA than the summation of the relMCAs to the corresponding ring and circle stimuli which combined create a 40° circle-stimulus. Latency was longer for rods than for cones. It decreased with increasing stimulus area for circle stimuli while it stayed nearly constant with increasing ring stimulus area for cone- and rod-specific stimuli.

Conclusion

The effect of central stimulation on relMCA is more dominant for cone-specific stimuli than for rod-specific stimuli while latency dynamics are similar for both conditions.
$${\mathcal {N}}=1$$ super topological recursion
Authors: Bouchard Vincent , Osuga Kento
Published: November 2021

We introduce the notion of $${\mathcal {N}}=1$$

N
=
1

abstract super loop equations and provide two equivalent ways of solving them. The first approach is a recursive formalism that can be thought of as a supersymmetric generalization of the Eynard–Orantin topological recursion, based on the geometry of a local super spectral curve. The second approach is based on the framework of super Airy structures. The resulting recursive formalism can be applied to compute correlation functions for a variety of examples related to 2d supergravity.
Transdisziplinäre Forschung in der Gesundheitsförderung bei Studierenden – ein systematisches Review
Authors: Gürster Antonia , Helten Jessica , Tittlbach Susanne
Published: November 2021

Hintergrund

Der Studienalltag ist durch Bewegungsmangel und hohe Sitzzeiten gekennzeichnet, was sich negativ auf die Gesundheit auswirkt. Die Implementierung von nachhaltigen Programmen zur Bewegungsförderung an Hochschulen gewinnt somit an Bedeutung. Es mehren sich wissenschaftliche Hinweise, dass Interventionen dann erfolgreich sind, wenn transdisziplinäre Methoden angewendet werden.

Fragestellung

Der Beitrag untersucht, welche Rolle transdisziplinäre Methoden bei der Entwicklung und Implementierung von gesundheitsfördernden Interventionen im Setting Hochschule bei Studierenden spielen und wie diese nachhaltig umgesetzt werden können.

Methodik

Es wurde ein systematisches Literaturreview deutsch- und englischsprachiger Studien durchgeführt. Entscheidend war, dass die Studien transdisziplinäre Interventionsansätze aufweisen sowie das Bewegungs- und Sitzverhalten von Studierenden berücksichtigen.

Ergebnisse

Von den 1211 identifizierten Datensätzen erfüllen 10 Studien die Auswahlkriterien. 3 Studien zielen auf eine Bewegungsförderung oder Sitzzeitreduktion ab, während 7 Studien allgemeine Gesundheitsförderung anstreben, bei der bewegungsfördernde Maßnahmen im Vordergrund stehen. Die Interventionstechniken sind Partizipation und Empowerment (n = 10), kooperative Planung (n = 8), interaktiver Wissensaustausch (n = 8) und Kapazitätsaufbau (n = 8).

Schlussfolgerung

Die Ergebnisse deuten darauf hin, dass die Anwendung von transdisziplinären Methoden zu mehr Akzeptanz und einer nachhaltigeren Etablierung führt. Weitere Studien sind erforderlich, um die Wirksamkeit von Interventionen unter Anwendung transdisziplinärer Methoden zu erforschen. Für transdisziplinäre Studien zur Verringerung des sitzenden Verhaltens von Studierenden besteht weiterer Forschungsbedarf.
Microstructure and Mechanical Properties of the Ductile Al–Ti–Mo–Nb–V Refractory High Entropy Alloys
Authors: Cieślak Grzegorz , Dąbrowa Juliusz , Jawańska Monika , Parzuchowska Agnieszka , Oleszak Dariusz
Published: November 2021

A number of non-equimolar refractory high entropy alloys (RF HEAs) from the Al–Ti–Mo–Nb–V system are synthesized, with the selected compositions aimed to balance the conflicting requirements of the low-temperature ductility and high-temperature corrosion protection. Based on the thermodynamic modeling and experimental results, all the obtained alloys are characterized by the single-phase B2 structure with V acting as the main phase stabilizer. The microstructure and mechanical properties appear to be controlled mainly by the Al content, which is
especially visible on the example of hardness, with a maximum value of 545 HV for Al20Ti5Mo25Nb25V25 composition. For the selected Al20Ti5Mo25Nb25V25 and Al10Ti30Mo20Nb20V20 alloys, the measured stress–strain curves indicate the highly coveted, ductile room temperature behavior, with the values of ultimate strain measured under compression mode being 9.17 and 9.00 pct, respectively, and compressive fracture strain of 13.38 and 13.25 pct, respectively. The obtained results suggest that it is possible to include Al as a vital component of refractory HEAs without compromising their low-temperature ductility. The next intended step will be the characterization of the high-temperature corrosion behavior in order to investigate the potential selective oxidation capabilities of such materials.
The Musculoskeletal Manifestations of Marfan Syndrome: Diagnosis, Impact, and Management
Authors: Pollock Lily , Ridout Ashley , Teh James , Nnadi Colin , Stavroulias Dionisios , Pitcher Alex , Blair Edward , Wordsworth Paul , Vincent Tonia L.
Published: November 2021

Purpose of Review

Marfan syndrome (MFS) is an autosomal dominant heritable disorder of fibrillin-1 (FBN1) with predominantly ocular, cardiovascular, and musculoskeletal manifestations that has a population prevalence of approximately 1 in 5–10,000 (Chiu et al. Mayo Clin Proc. 89(1):34–42, 146, Dietz 3, Loeys et al. J Med Genet. 47(7):476–85, 4).

Recent Findings

The vascular complications of MFS still pose the greatest threat, but effective management options, such as regular cardiac monitoring and elective surgical intervention, have reduced the risk of life-threatening cardiovascular events, such as aortic dissection. Although cardiovascular morbidity and mortality remains high, these improvements in cardiovascular management have extended the life expectancy of those with MFS by perhaps 30–50 years from an estimated mean of 32 years in 1972 (Dietz 3, Gott et al. Eur J Cardio-thoracic Surg. 10(3):149–58, 147, Murdoch et al. N Engl J Med. 286(15):804–8, 148). The musculoskeletal manifestations of MFS, which to date have received less attention, can also have a significant impact on the quality of life and are likely to become more important as the age of the Marfan syndrome population increases (Hasan et al. Int J Clin Pract. 61(8):1308–1320, 127). In addition, musculoskeletal manifestations are often critically important in the diagnosis of MFS.

Here, we review the main clinically relevant and diagnostically useful musculoskeletal features of MFS, which together contribute to the “systemic features score” (referred to hereafter as systemic score), part of the revised Ghent nosology for MFS. We discuss current treatment strategies and highlight the need for a multidisciplinary approach to diagnosis and management. Finally, we review new pharmacological approaches that may be disease modifying and could help to improve the outcome for individuals with this syndrome.
Intercellular Propagation and Aggregate Seeding of Mutant Ataxin-1
Authors: Huang Haoyang , Toker Nicholas , Burr Eliza , Okoro Jeff , Moog Maia , Hearing Casey , Lagalwar Sarita
Published: November 2021

Intercellular propagation of aggregated protein inclusions along actin-based tunneling nanotubes (TNTs) has been reported as a means of pathogenic spread in Alzheimer’s, Parkinson’s, and Huntington’s diseases. Propagation of oligomeric-structured polyglutamine-expanded ataxin-1 (Atxn1[154Q]) has been reported in the cerebellum of a Spinocerebellar ataxia type 1 (SCA1) knock-in mouse to correlate with disease propagation. In this study, we investigated whether a physiologically relevant polyglutamine-expanded ATXN1 protein (ATXN1[82Q]) could propagate intercellularly. Using a cerebellar-derived live cell model, we observed ATXN1 aggregates form in the nucleus, subsequently form in the cytoplasm, and finally, propagate to neighboring cells along actin-based intercellular connections. Additionally, we observed the facilitation of aggregate-resistant proteins into aggregates given the presence of aggregation-prone proteins within cells. Taken together, our results support a pathogenic role of intercellular propagation of polyglutamine-expanded ATXN1 inclusions.
Potential Utility of Adjunct Imaging with Wide-Field Optical Coherence Tomography for Gross and Microscopic Evaluation of Breast Specimens in Real-Time in the Operating Suite
Authors: DuPree Beth B. , Papez Michael J. , Pirruccello Elaina , Hassenflug Audrey
Published: November 2021

One challenge in the surgical management of breast cancer is maximizing the preservation of healthy tissue while achieving acceptable negative margins. Tools capable of assessing disease-margin involvement intraoperatively and in real-time could provide clinically useful guidance regarding the adequacy of margin resection before the surgery is over. Here we report the intraoperative use of optical coherence tomography (OCT) in 3 patients with DCIS. In all 3 cases, additional lesions identified by OCT during surgery were also noted in histopathology reports 3 to 5 days post-surgery, suggesting that intraoperative use of OCT is a valuable  tool for margin determination in real-time.
Twitter as a Medical Media Among French Young Oncologists: Results from a National Survey
Authors: Roulleaux Dugage Matthieu , Naoun Natacha , Bommier Côme , Michalet Morgan , Loriot Yohann , Blanchard Pierre , Hilmi Marc , Soria Jean-Charles
Published: November 2021

Since its launch in 2006, Twitter has become a commonly used platform for sharing medical information, especially in the field of oncology. However, its role and impact on young oncologists’ education remain unclear. Moreover, COVID-19 and congress virtualization is likely to have modified Twitter use by the medical society.

We conducted a national survey (27 questions) in France among medical oncology, hematology, and radiation therapy young doctors to help better understand the role played by Twitter on their medical education. One hundred eighty-three young oncologists participated in our survey. A majority does not use Twitter (72.1%), mostly to reduce their time spent on social media. Participants using Twitter (27.9%) often use it more than once a week, mostly by scrolling on their news feed. Interestingly, they rarely express their own opinion on Twitter: a majority of them (75.5%) tweet less than once a month while the rest of them mostly retweet others’ tweets. They mainly follow English-speaking experts, scientific societies, and medical journals. Pharmaceutical laboratories’ accounts are of less significance. Overall Twitter usage seems increasing since COVID-19 pandemic and the consequent digitalization of congresses. No statistical difference was observed between the baseline characteristics of Twitter users and non-users.

This survey shows that Twitter is a relevant mean of continuous medical education used by around a third of French young oncologists, especially since COVID-19 pandemic and the virtualization of congresses. This media should be considered and evaluated for its educational advantages or potential biases.
Surface mapping, structural modelling and kinematics along the sinistral strike-slip fault zone, NE Potwar, Pakistan
Authors: Nouman Muhammad , Rehman Gohar , Yaseen Muhammad , Wahid Sohail , Safi Ibrahim , Ahmad Jawad , Van Hao Duong
Published: November 2021

This research was carried out to understand the nature of strike-slip Jhelum Fault zone and to propose a model for the surface to subsurface deformation pattern. Field data along with satellite images are used to construct the geological map. Moreover, the subsurface model has been proposed using the mechanism of dip-isogons in computer application which connects points of equal inclination or dip on the outer and inner bounding surfaces of a folded layers. The proposed geological map and subsurface model shows that the Jhelum Fault when propagated in the south from Hazara-Kashmir Syntaxis forms a continuous shear zone on surface with some discontinuous exposure of splay faults rather than exposed as continuous discrete break. Likewise, the subsurface cross sections show that deformation along the fault zone is accumulated by splay faults from the main Jhelum Fault, which forms a positive flower structure with steep north-eastward dips, which is characteristics of strike-slip movement along Jhelum Fault Zone. The vertical stratigraphic throw along these faults shows small offsets and little east–west shortening, indicating that the major slip along the fault is strike slip.
Gefährdungsbeurteilung psychischer Belastung
Authors: Kersten Maren , Kozak Agnessa , Adler Mareike , Wohlert Claudia , Stamer Susanne , Gregersen Sabine
Published: November 2021

Hintergrund

Die Gefährdungsbeurteilung psychischer Belastung hat zum Ziel, die durch die Arbeit verbundenen Gefährdungen zu beurteilen, um Maßnahmen zur gesundheitsgerechten Gestaltung der Arbeit abzuleiten. Allerdings ist das Angebot an Verfahren für die Ermittlung der psychischen Belastung umfangreich und unübersichtlich. Vor diesem Hintergrund wird für das Sozial- und Gesundheitswesen ein reduzierter und strukturierter Überblick an Instrumenten vorgestellt.

Methode

Für die Identifizierung geeigneter Instrumente wurde eine umfangreiche Suche durchgeführt. Vor Recherchebeginn wurden Kriterien definiert, um die identifizierten Instrumente auf Eignung zu prüfen. Zum einen gab es Mindestanforderungen, die erfüllt sein mussten, damit das Instrument in den Review-Prozess aufgenommen wurde, und zum anderen Strukturierungskriterien, die sich in beschreibende und bewertende Aspekte unterteilten.

Ergebnisse

Die Recherche identifizierte insgesamt 83 Instrumente für die Gefährdungsbeurteilung psychischer Belastung (GBU Psyche); nach der ersten Sichtung wurden 58 von diesen zur weiteren Eignung im Review-Prozess übernommen. Abgeschlossen wurde das Gesamtreview bisher für 44 Verfahren aus der unsystematischen Suche. Davon wurden 19 Verfahren als geeignet eingestuft und in einer Übersichtsmatrix strukturiert dargestellt. Das Review für die 14 Verfahren aus der systematischen Recherche erfolgt voraussichtlich bis Mitte 2022 und ist Teil eines kontinuierlichen Review-Prozesses.

Diskussion

Die Vielzahl an identifizierten Verfahren für die GBU Psyche (Gefährdungsbeurteilung psychischer Belastung) zeigt deutlich die Sinnhaftigkeit und Relevanz, eine begrenzte, praxiserprobte sowie qualitätsgesicherte Auswahl an Instrumenten zu treffen. Die ebenfalls in diesem Artikel dargestellten Kriterien zur Bewertung der Instrumente, machen die getroffene Auswahl transparent.
Stability Mechanism of Laser-induced Fluorinated Super-hydrophobic Coating in Alkaline Solution
Authors: Li Haoyang , Tian Yanling , Yang Zhen
Published: November 2021

Great attention has been focused on super-hydrophobic surfaces due to their fantastic applications. Fluoride chemicals are widely used to fabricate super-hydrophobic surfaces due to their convenience, simplicity, and high efficiency. Previous research has made extensively efforts on corrosion resistance of fluorinated super-hydrophobic surfaces in corrosive media. Nevertheless, rare papers focused on the underlying reasons of anticorrosion property and stability mechanism on the fluorinated super-hydrophobic coatings in alkaline solution. Therefore, this work aims to reveal these mechanisms of fluorinated super-hydrophobic copper samples in strong alkaline solution (pH 13). Through the characterization of surface wettability and surface morphology, the laser-induced super-hydrophobic surface retained excellent stability after soaking in alkaline solution for 4 h. Through measurement of chemical compositions, the anticorrosion mechanism and stability mechanism of the fluorinated super-hydrophobic surface were proposed. Importantly, the hydroxyl ion (OH−) can further promote the hydrolysis reaction to improve the density and bonding strength of the fluoride molecules. Finally, the electrochemical experiments (PDP and EIS tests) were conducted to validate the rationality of our proposed conclusions.
Perception and Action in a Social Context
Authors: Azaad Shaheed , Knoblich Günther , Sebanz Natalie
Published: November 2021

Even the simplest social interactions require us to gather, integrate, and act upon, multiple streams of information about others and our surroundings. In this Element, we discuss how perceptual processes provide us with an accurate account of action-relevant information in social contexts. We overview contemporary theories and research that explores how: (1) individuals perceive others' mental states and actions, (2) individuals perceive affordances for themselves, others, and the dyad, and (3) how social contexts guide our attention to modulate what we perceive. Finally, we review work on the cognitive mechanisms that make joint action possible and discuss their links to perception.
Explore the Approaches to Corporate Social Responsibility Implemented by E-Commerce Platforms in China During the Early Stage of COVID-19: A Mixed-Methods Content Analysis
Authors: Zhang Yang , Li Jingyi , Lei Yongsen , Yan Tengjun
Published: November 2021

Objectives:

The aim of this study was to explore (a) the approaches to corporate social responsibility (CSR) implemented by e-commerce platforms in China during the early stage of coronavirus disease 2019 (ESCOVID-19) and (b) the factors associated with the platforms’ choice of these approaches.

Methods:

We collected the CSR data from the Internet during ESCOVID-19. Conventional content analysis was used to develop the targeted approaches. Finally, based on the frequency analysis of each approach, rank-based nonparametric testing was conducted to answer objective (b).

Results:

Three main approaches (ie, donative CSR actions, responsive CSR actions, and strategic CSR actions) and 8 subapproaches were implemented. The strategic approach was the most frequently used approach. The platforms with higher market size implemented more donative and strategic CSR actions than did the platforms with lower market size. Donative CSR actions were significantly implemented in the earlier period, while strategic CSR actions were significantly implemented in the later period.

Conclusions:

Our research highlights the importance of e-commerce platforms to help the public survive and identifies that market size and time were associated with the platforms’ CSR choice. The design of prevention and control policies should incorporate and support e-commerce platforms and evaluate the factors when confronting future public health crises.
Alveolar macrophages: novel therapeutic targets for respiratory diseases
Authors: Lim Pamelia N. , Cervantes Maritza M. , Pham Linh K. , Rothchild Alissa C.
Published: November 2021

Alveolar macrophages (AMs) are lung-resident myeloid cells that sit at the interface of the airway and lung tissue. Under homeostatic conditions, their primary function is to clear debris, dead cells and excess surfactant from the airways. They also serve as innate pulmonary sentinels for respiratory pathogens and environmental airborne particles and as regulators of pulmonary inflammation. However, they have not typically been viewed as primary therapeutic targets for respiratory diseases. Here, we discuss the role of AMs in various lung diseases, explore the potential therapeutic strategies to target these innate cells and weigh the potential risks and challenges of such therapies. Additionally, in the context of the COVID-19 pandemic, we examine the role AMs play in severe disease and the therapeutic strategies that have been harnessed to modulate their function and protect against severe lung damage. There are many novel approaches in development to target AMs, such as inhaled antibiotics, liposomal and microparticle delivery systems, and host-directed therapies, which have the potential to provide critical treatment to patients suffering from severe respiratory diseases, yet there is still much work to be done to fully understand the possible benefits and risks of such approaches.
Can stratification biomarkers address the heterogeneity of autism spectrum disorder?
Authors: Molloy C. J. , Gallagher L.
Published: November 2021

The search for biomarkers for autism spectrum disorder (henceforth autism) has received a lot of attention due to their potential clinical relevance. The clinical and aetiological heterogeneity of autism suggests the presence of subgroups. The lack of identification of a valid diagnostic biomarker for autism, and the inconsistencies seen in studies assessing differences between autism and typically developing control groups, may be partially explained by the vast heterogeneity observed in autism. The focus now is to better understand the clinical and biological heterogeneity and identify stratification biomarkers, which are measures that describe subgroups of individuals with shared biology. Using stratification approaches to assess treatment within pre-defined subgroups could clarify who may benefit from different treatments and therapies, and ultimately lead to more effective individualised treatment plans.
Turbulent flow in curved channels
Authors: Brethouwer Geert
Published: November 2021

Fully developed turbulent flow in channels with mild to strong longitudinal curvature is studied by direct numerical simulations. The Reynolds based on the bulk mean velocity and channel half-width

$\delta$

is fixed at

$20\,000$

, resulting in a friction Reynolds number of approximately 1000. Four cases are considered with curvature varying from

$\gamma = 2\delta /r_c = 0.033$

to 0.333, where

$r_c$

is the curvature radius at the channel centre. Substantial differences between the mean wall shear stress on the convex and concave walls are already observed for

$\gamma = 0.033$

. A log-law region is absent and a region with nearly constant mean angular momentum develops in the channel centre for strong curvatures. Spanwise and wall-normal velocity fluctuations are strongly amplified by curvature in the outer region of the concave channel side. Only near the walls, where curvature effects are relatively weak, do the mean velocity and velocity fluctuation profiles approximately collapse when scaled by wall units based on the local friction velocity. Budgets of the streamwise and wall-normal Reynolds-stress equations are presented and turbulence structures are investigated through visualizations and spectra. In the case with strongest curvature, the flow relaminarizes locally near the convex wall. On the concave channel side, large elongated streamwise vortices reminiscent of Taylor–Görtler vortices develop for all curvatures considered. The maximum in the premultiplied two-dimensional wall-normal energy spectrum and co-spectrum shifts towards larger scales with increasing curvature. The large scales substantially contribute to the wall-normal velocity fluctuations and momentum transport on the concave channel side.
Transoral endoscopic approach to upper cervical spine migrated foreign bodies
Authors: Png L H , Toh S T , Teo N W Y
Published: November 2021

Background

Migrated ingested foreign bodies in the aerodigestive tract can lodge within vital organs and vessels, causing potentially devastating complications. It is often difficult to localise these foreign bodies, with extrication resulting in the requirement for open approaches which may cause significant morbidity.

Case report

This paper presents the case of an ingested migrated stingray bone lodged adjacent to the vertebral artery in the upper cervical spine. This was managed via an endoscopic transoral approach, with the assistance of an image-guidance system.

Results

Successful extraction of the foreign body was achieved, with minimal residual morbidity.

Conclusion

Our study showed that image-guided endoscopic surgery is a safe, precise and feasible option for the localisation and removal of migrated foreign bodies in the aerodigestive tract involving critical neurovascular structures.
Radiation pressure acceleration of protons from structured thin-foil targets
Authors: Meinhold Tim Arniko , Kumar Naveen
Published: November 2021

The process of radiation pressure acceleration (RPA) of ions is investigated with the aim of suppressing the Rayleigh–Taylor-like transverse instabilities in laser–foil interaction. This is achieved by imposing surface and density modulations on the target surface. We also study the efficacy of RPA of ions from density modulated and structured targets in the radiation dominated regime where the radiation reaction effects are important. We show that the use of density modulated and structured targets and the radiation reaction effects can help in achieving the twin goals of high ion energy (in GeV range) and lower energy spread.
Protecting concessionary rights: General principles and the making of international investment law
Authors: Leiter Andrea
Published: November 2021

This article engages with the history of international investment law in the first half of the twentieth century. It traces how international lawyers inscribed their vision of an international legal order protecting private property of Western companies against attempts at nationalization in the wake of socialist revolutions and the decolonization of large parts of the world. The article focuses on the role of ‘general principles of law as recognized by civilized nations’ as building blocks for an international legal order today called international investment law. Rather than describing a direct line between contemporary standards of protection and the invocation of general principles, the article develops conditions of possibility for the emergent field of international investment law. These conditions are located both in arbitral practice, as well as in international legal scholarship of the early twentieth century. Based on the analysis of such arbitrations over disputes resulting from concession agreements and scholarly writings in the interwar period, the contribution draws out the modes of authorization upon which the legal claims advanced by international lawyers rested. At the heart of the vision were ideas of ‘modernity’, ‘civilization’, ‘equity’, and ‘justice’ that enabled a hierarchization of difference, locating Western claims to legality above rivalling claims of socialist and ‘newly independent’ states. These ideas ultimately constituted the paradox of a ‘modern law of nature’ that claimed timeless universality while authorizing the ordering of foreign property in line with Western conceptions of modernity.
Creating a new future: Redeveloping the tribal-museum relationship in the time of NAGPRA
Authors: Teeter Wendy Giddens , Martinez Desiree , Lippert Dorothy
Published: November 2021

The hope has long been that the Native American Graves Protection and Repatriation Act (NAGPRA) would finally bring ancestors and their cultural items home to their communities to be reconnected and rest. However, 30 years later, museums and academics still fear losing control of research and access in their intellectual pursuits. Far from true, museums have benefited in working with tribes in telling stories around their cultural history, present and future. This article shares experiences over the authors’ careers and counters the alarmist calls to arms against compliance with NAGPRA.
Formalization of metatheory of the Lambda Calculus in constructive type theory using the Barendregt variable convention
Authors: Copello Ernesto , Szasz Nora , Tasistro Álvaro
Published: November 2021

Abstarct

We formalize in Constructive Type Theory the Lambda Calculus in its classical first-order syntax, employing only one sort of names for both bound and free variables, and with α-conversion based upon name swapping. As a fundamental part of the formalization, we introduce principles of induction and recursion on terms which provide a framework for reproducing the use of the Barendregt Variable Convention as in pen-and-paper proofs within the rigorous formal setting of a proof assistant. The principles in question are all formally derivable from the simple principle of structural induction/recursion on concrete terms. We work out applications to some fundamental meta-theoretical results, such as the Church–Rosser Theorem and Weak Normalization for the Simply Typed Lambda Calculus. The whole development has been machine checked using the system Agda.
Finitary monads on the category of posets
Authors: Adámek Jiří , Ford Chase , Milius Stefan , Schröder Lutz
Published: November 2021

Finitary monads on Pos are characterized as precisely the free-algebra monads of varieties of algebras. These are classes of ordered algebras specified by inequations in context. Analogously, finitary enriched monads on Pos are characterized: here we work with varieties of coherent algebras which means that their operations are monotone.
Jain Memory of the Tughluq Sultans: Alternative Sources for the Historiography of Sultanate India
Authors: VOSE STEVEN M.
Published: November 2021

Some of the earliest narratives of meetings between leaders of an Indian community and their Muslim ruler appear in the Vividhatīrthakalpa (Chapters on Many Sacred Places) of the Jain monk Jinaprabhasūri (c. 1261–1333 ce). The text depicts the monk's relationship with Sultan Muḥammad bin Tughluq (r. 1325–51) in the years 1328–33, which resulted in the sovereign issuing a number of edicts (farmāns) to protect Jains and Jain temples and which led to the return of a Jina icon (Pkt. paḍima, Skt. pratimā) and the establishment of a Jain quarter in Delhi. Over the next two-and-a-half centuries, Jinaprabhasūri's story would be retold several times, with fifteenth-century narrators shifting his interlocutor to Fīrūz Shāh Tughluq (r. 1351–88). In the process of making Jinaprabha an object of memory, Jain authors of both the monk's own and rival monastic orders (gacchas) depicted the sultans as benefactors of the Jain community. While these narratives were attempts to delineate the proper relationship between Jain monastic leaders and Muslim rulers, they also constituted a Jain memory of the Tughluq sultans that is often at odds with modern historical representations of them. Reading these narratives alongside other evidence of Jains’ relations with the Tughluqs offers historians an alternative view of these figures and their relations with their Indian subjects, helping to de-centre modern historical narratives based on selective readings of Persian and Arabic sources and a privileging of Brahmanical or colonial viewpoints of the period. However, these narratives require historians to theorise this ‘memory’ to understand them productively as historical sources.
Locating Ḥākimiyya in Global History: The Concept of Sovereignty in Premodern Islam and Its Reception after Mawdūdī and Quṭb
Authors: AL-AZAMI USAAMA
Published: November 2021

The concept of ḥākimiyya (sovereignty), as understood by its leading proponents, refers to the notion that it is God, rather than humans, Who possesses the prerogative to make laws. A concomitant of this is that Muslims with political power and authority must recognise the supremacy of Islamic law. This notion, perhaps most notably articulated in modern times by Abū al-Aʿlā Mawdūdī, may be viewed as the rearticulation of ideas latent in the premodern Islamic juristic tradition, but whose modern incarnation as ḥākimiyya emerged in response to the legislative norms of the liberal colonial state. Despite its modern articulation, and against the views of several scholars, I argue that ḥākimiyya qua sovereignty finds its antecedents quite clearly in the Islamic scholarly tradition. Such an understanding leads into a discussion of how Islamic conceptions of sovereignty can help us reassess influential Western articulations of the concept. I also show that Mawdūdī's influential younger contemporary, the Islamist alim Abū al-Ḥasan ʿAlī Nadwī, upholds ḥākimiyya despite his critique of Mawdūdī and Sayyid Quṭb's conceptions of it. I conclude with a brief reflection on how our understanding of ḥākimiyya as sovereignty can help us provincialise Europe in global historical studies.
Comparative dosimetry of brachytherapy treatment planning between a volume-based plan by CT and a point-based plan by TAUS in CT datasets for brachytherapy
Authors: Pintakham Chaiyaporn , Tharavichitkul Ekkasit , Wanwilairat Somsak , Nobnop Wannapha
Published: November 2021

Aim:

To evaluate comparative dosimetry of brachytherapy treatment planning between a volume-based plan by computed tomography (CT) and a point-based plan by transabdominal ultrasound (TAUS) in CT datasets for brachytherapy.

Materials and methods:

From 2019 to 2021, 59 different datasets of CT images were collected from 38 patients treated by intracavitary brachytherapy with tandem ovoid or tandem ring applicators. At that time, TAUS was performed to prevent uterine perforation and to evaluate topography of the cervix during application. In volume-based planning by CT, the target dose was used to keep the dose at 90% of high-risk clinical target volume (HR-CTV), to give a dose of at least 7Gy, while in the point-based plan by TAUS, the target dose was used to keep the minimum dose to eight cervix reference points (measured by TAUS), to give a dose of at least 7Gy. The doses to targets and organs at risk were evaluated and compared between volume-based planning by CT and the point-based plan by TAUS.

Results:

Of 59 fractions, a tandem ovoid applicator was used in 48 fractions (81·3%). In the volume-based plan by CT, the mean doses to HR-CTV(D90), intermediate-risk clinical target volume (IR-CTV)(D90), bladder(D2cc), rectum(D2cc) and sigmoid colon(D2cc) were 7·0, 3·9, 4·9, 2·9 and 3·3 Gy, respectively, while in the point-based plan by TAUS, the mean doses to HR-CTV(D90), IR-CTV(D90), bladder(D2cc), rectum(D2cc) and sigmoid colon(D2cc) were 8·2, 4·6, 5·9, 3·4 and 3·9 Gy, respectively. The percentages of mean dose differences between TAUS and CT of HR-CTV(D90), IR-CTV(D90), bladder(D2cc), rectum(D2cc) and sigmoid colon(D2cc) were 17·7, 19·5, 20·5, 19·5, 21·3 and 19·8%, respectively. With the target dose to the point-based plan by TAUS (7 Gy to the cervix reference points), this was close to D98 of HR-CTV with a mean percentage of difference of 0·6%.

Findings:

The point-based plan by TAUS showed higher values to targets and organs at risk than the volume-based plan by CT. With the point-based plan by TAUS, it was close to D98 of HR-CTV.