bluuebunny/crossref_metadata_2025 huggingface dataset:
Sex differences and immune correlates of Long Covid development, symptom persistence, and resolution
Authors: Hamlin Rebecca E. , Pienkos Shaun M. , Chan Leslie , Stabile Mikayla A. , Pinedo Kassandra , Rao Mallika , Grant Philip , Bonilla Hector , Holubar Marisa , Singh Upinder , Jacobson Karen B. , Jagannathan Prasanna , Maldonado Yvonne , Holmes Susan P. , Subramanian Aruna , Blish Catherine A.
Published: November 2024

Sex differences have been observed in acute coronavirus disease 2019 (COVID-19) and Long Covid (LC) outcomes, with greater disease severity and mortality during acute infection in males and greater proportions of females developing LC. We hypothesized that sex-specific immune dysregulation contributes to LC pathogenesis. To investigate the immunologic underpinnings of LC development and symptom persistence, we performed multiomic analyses on blood samples obtained during acute severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and 3 and 12 months after infection in a cohort of 45 participants who either developed LC or recovered. Several sex-specific immune pathways were associated with LC. Males who would later develop LC exhibited increases in transforming growth factor–β (TGF-β) signaling during acute infection, whereas females who would go on to develop LC had reduced
TGFB1
expression. Females who developed LC demonstrated increased expression of
XIST
, an RNA gene implicated in autoimmunity, during acute infection compared with females who recovered. Many immune features of LC were also conserved across sexes, such as alterations in monocyte phenotype and activation state. Nuclear factor κB (NF-κB) transcription factors were up-regulated in many cell types at acute and convalescent time points. Those with ongoing LC demonstrated reduced
ETS1
expression across lymphocyte subsets and elevated intracellular IL-4 in T cell subsets, suggesting that
ETS1
alterations may drive aberrantly elevated T helper cell 2–like responses in LC. Altogether, this study describes multiple innate and adaptive immune correlates of LC, some of which differ by sex, and offers insights toward the pursuit of tailored therapeutics.
Exploring the impact of deglaciation on fault slip in the Sangre de Cristo Mountains, Colorado, USA
Authors: Hurtado Cecilia , Gallen Sean F.
Published: November 2024

Few natural examples exist where climate’s influence on tectonics is clear. Based on a study of the Sangre de Cristo Mountains in southern Colorado, we argue that climate-driven changes in ice loads affected spatial and temporal slip patterns on the range-front normal fault. Relict glacial features enable the reconstruction of paleoglacier extents and show variable amounts of footwall ice coverage during the Last Glacial Maximum (LGM). Line load models indicate post-LGM ice melting reduced fault clamping stress by ~20–55 kPa at seismic depths. Flexural isostatic modeling shows several meters of footwall uplift due to ice unloading with spatial patterns and magnitudes consistent with post-LGM fault throw measured from offset Holocene and late Pleistocene alluvial fans. Post-LGM fault throw rates are at least a factor of five higher than middle and early Pleistocene rates. We infer that climate-modulated ice-load changes can pace fault clamping stress and slip patterns on range-bounding normal faults.
Supplemental Material: Rapid pyrolysis of paleo-oil pools recorded by fluid inclusions in an Ediacaran carbonate reservoir, southern China: Implications for the end-Guadalupian mass extinction
Authors: Yang Peng , Liu Keyu , al. et
Published: November 2024

Samples and methods, Figures S1–S2, and Tables S1–S8. 
Differences in the pathological, transcriptomic, and prognostic implications of lymphoid structures between primary and metastatic cutaneous melanomas
Authors: Karapetyan Lilit , Li Aofei , Vargas De Stefano Danielle , Abushukair Hassan M , Al-Bzour Ayah N , Knight Andrew , Layding Caroline , Wang Hong , Xu Jin , Yao Jiqiang , Song Xiaofei , Joy Marion , Nguyen Jonathan , Moran-Segura Carlos , Bruno Sabrina , Sander Cindy , Messina Jane , Mule James J , Storkus Walter J , Kirkwood John M
Published: November 2024

Background

While the prognostic role of tertiary lymphoid structures (TLS) has been well studied in solid cancers, the prevalence and impact of immature precursor lymphoid structures known as lymphoid aggregates (LA) remain unresolved in relation to the disease process. In this study, we examined characteristics and the prognostic utility of LA and TLS status in histological samples from patients with melanoma.

Methods

We assessed The Cancer Genomic Atlas-skin cutaneous melanoma digital slides and melanoma specimens from the University of Pittsburgh for the presence of LA and TLS using H&E staining, multiplex immunofluorescence (mIF) and transcriptomic analyses. Cox proportional hazard regression models were used to assess the prognostic value associated with the presence of lymphoid structures in melanomas.

Results

A total of 278 evaluable samples were analyzed and split into primary melanomas in skin (N=195) and metastatic melanomas involving skin/subcutaneous/soft tissue sites (N=83). 72% of tumor specimens contained histologically defined LA located in peritumoral (34%), intratumoral (5.6%) or stromal (6.1%) locations, with the remaining samples (54.3%) exhibiting LA in multiple locations. In contrast to LA which tended to form more commonly in primary melanoma samples, TLS with germinal centers predominantly formed in peritumoral (45.2%) or stromal (35.5%) locations in metastatic melanomas (p=0.02), with TLS observed in 11% of all melanoma specimens evaluated. mIF analyses revealed cellular heterogeneity of lymphoid structures, with CD20+(B) cells present in nodule-shaped and stromal locations where they exhibited a high degree of colocalization with CD4+and CD8+T cells. A previously defined 12-chemokine gene expression score was significantly higher in samples with evidence of LA versus none (p<0.001), and samples without LA/TLS were enriched with pigmentation/neural network gene signatures. The presence of LA was significantly associated with tumor-free regional lymph node status (p=0.002). In multivariable analysis, after adjusting for age, sex, sample type, and stage, the presence of LA was associated with improved patient overall survival (OS) (HR=0.52, 95% CI 0.31 to 0.87, p=0.01).

Conclusion

Melanoma frequently contains LA, which tends to form in diverse locations in the tumor microenvironment in association with improved overall survival and tumor-free regional lymph node status in patients with primary disease.
Seasonality and interannual variability of an Arctic marine time series, IsA
Authors: Vader Anna , Handler Eleanor , Skogseth Ragnheid , Larsen Aud , Gabrielsen Tove M.
Published: November 2024

The Arctic is warming twice as fast as anywhere else on the planet, in the European Arctic mainly driven by exalted Atlantic Water inflow. Microbial eukaryotes are diverse and essential to the functioning of marine ecosystems, thus environmental perturbations altering their communities influence the entire ecosystem. To study seasonal and interannual variation and the potential effects of Atlantification, a long-term marine time series has been established in Isfjorden-Adventfjorden, West Spitsbergen. We here present 3 years of high-resolution data including hydrography, nutrients, photosynthetic biomass, flow cytometry and community composition of microbial eukaryotes (0.45–10 µm, based on Illumina metabarcoding of 18S rDNA and rRNA). The timing, magnitude and species composition of the spring bloom varied interannually, with the more Atlantic spring 2014 being distinctly different from the two other years. A strong recurring seasonal pattern was evident in biodiversity, cell abundances and community composition. Winter communities were characterized by high alpha diversity and very low cell numbers with a dominance of heterotrophic and parasitic taxa. Despite large intra- and interannual differences in communities during the productive time of the year, winter communities were always highly similar, suggesting that the polar night represents a strong environmental forcing that resets the microbial communities.
Building the foundation for polar bear science: fifty years of research on polar bears in Western Hudson Bay
Authors: Biddlecombe B.A. , Derocher A.E. , Krebs E. , Lunn N.J. , McGeachy D. , Richardson E.S.
Published: November 2024

In 1966, Environment and Climate Change Canada (ECCC) (then Canadian Wildlife Service) initiated a research program on polar bears ( Ursus maritimus, Phipps, 1774) belonging to the Western Hudson Bay subpopulation (WH). This paper provides an overview of that program, highlighting the long-term research on WH polar bears with a focus on ECCC-led work. The WH research program, which has now extended across five decades with data on over 4600 individual bears, has evolved from a study of the basic ecology of polar bears into foundational work on the life history, demography, genetics, movement, behaviour, and ecology of an apex predator in a rapidly changing Arctic. Research on polar bears in Canada supports commitments under the Agreement on the Conservation of Polar Bears (1973), the Convention on Biological Diversity (1992), and Canada’s Species at Risk Act (2002). Among Canada’s 13 polar bear subpopulations, only WH has sufficient long-term monitoring of individuals to assess demographic, behavioural, and life history consequences of climate change and other anthropogenic stressors. Future research should continue to ask key questions on how long-term environmental changes impact the ecology of polar bears. Integrating community priorities into the research program is necessary for it to continue to be successful in the future.
Youth COVID-19 stressors and associations with self-perceived health, depression, anxiety, and at-risk alcohol and cannabis use
Authors: Afifi Tracie O. , Fortier Janique , Salmon Samantha , Taillieu Tamara , Osorio Ana , Roos Leslie , Stewart-Tufescu Ashley , Tonmyr Lil , Gonzalez Andrea , Kimber Melissa , Sareen Jitender , MacMillan Harriet L.
Published: November 2024

Adolescents and young adults have been particularly vulnerable to disruptions caused by the COVID-19 pandemic. The objectives were to identify youth's self-reported pandemic-related stressors and examine how these stressors were related to six negative health outcomes: self-perceived, fair-to-poor physical, and mental health, depression, anxiety, and at-risk alcohol and cannabis use. Data were from the Well-Being and Experiences Study (The WE Study) from Manitoba, Canada (17–22 years old; n = 587; collected from November 2021 to January 2022). The COVID-19 stressors reported most frequently since pandemic onset included: (1) not being able to spend time with friends (78.5%); (2) feeling lonely or isolated (69.9%); and (3) remote learning for school, college, or university (68.4%). In reference to the “past month”, frequently reported stressors were (1) remote learning (42.6%); (2) feeling lonely or isolated (41.2%); and (3) uncertainty about the future (41.1%). Overall, 26.1% of the sample perceived their physical health as fair-to-poor and 59.1% perceive their mental health as fair-to-poor. A number of stressors were related to fair-to-poor mental health, depression, and anxiety; fewer were related to fair-to-poor physical health and at-risk alcohol and cannabis use. These findings can inform future pandemics and recovery efforts to improve pandemic-related health risks among youth.
Emerging Long-Term Risks of the Use of Proton Pump Inhibitors and Potassium-Competitive Acid Blockers
Authors: Jankovic Katarina , Gralnek Ian M. , Awadie Halim
Published: November 2024

Acid-related disorders represent a significant global health burden. Pharmacological treatment of these conditions has at times been challenged and limited by incomplete effectiveness, antibiotic resistance, adverse medication effects and/or interactions, and disease recurrence. Since the early 1990s, the mainstay of treatment has been proton pump inhibitors (PPIs). Recently, the US Food and Drug Administration issued a clearance for vonoprazan, a potassium-competitive acid blocker (PCAB). PCABs are a new class of acid-suppressing agents that may overcome some of these challenges. The aim of this review is to evaluate and compare the emerging long-term risks of PPI and PCAB therapies.
Effect of Mixed Manure and Inorganic Fertilizer on Phosphorus Adsorption and Desorption Characteristics of Vertisols in Haramaya District, Eastern Ethiopia
Authors: Teressa Dejene , Kibret Kibebew , Dechasa Nigussie , Wogi Lemma
Published: November 2024

Applying inorganic phosphorus fertilizer is less effective in increasing crop yields in tropical soils due to precipitation and adsorption reactions. However, research suggests that partial substitution of organic and inorganic fertilizers has shown to improve the efficiency of applied phosphorus fertilizer by reducing its adsorption and enhancing desorption due to their synergistic effects. This study aimed to investigate the impact of treating the soil with mixed manure (MM) rates and blended nitrogen, phosphorus, sulfur, and boron (NPSB) fertilizer on the soil’s phosphorus adsorption and desorption characteristics. Results showed increased adsorbed phosphorus in all treatments, with increased added phosphorus (P) concentration from 100 to 500 mg kg−1. However, the efficiency of adsorbed P decreased significantly as added P concentration rates increased from 100 to 400 mg·kg−1 in all treatments and then decreased as the added P concentration advanced to 500 mg·kg−1. Moreover, in all treatments that received combined applications of MM and blended NPSB, both quantity and percentage of desorbed P showed a significant increase. The Freundlich adsorption coefficient and constant were also significantly reduced because of the combined application of MM and blended NPSB, compared to the control and their sole applications. Overall, the soil treated with a combined application of 15 t·ha−1 of MM with 100 kg·ha−1 of blended NPSB showed the highest reduction in the efficiency of adsorbed P, percentage of desorbed P, Freundlich adsorption capacity, and intensity by 8%, 37.5%, 60%, and 58%, respectively, as compared to the control. These findings indicate that the combined application of MM and blended NPSB can improve the P availability and uptake by maize by reducing its adsorption while increasing desorption characteristics. Finally, this experiment recommends further research on the long‐term effects of MM and blended NPSB on P adsorption and desorption characteristics of vertisols.
Integrating Network Pharmacology and Metabolomics to Explore the Potential Mechanism of β‐Sitosterol Against Hyperuricemia Nephropathy
Authors: Yang Fan , Sun Lu , Gao Yingjie , Liang Jingzhen , Ye Wenqian , Yang Wenjing , Xie Siyi , Zhou Jiangtao , Li Rongshan
Published: November 2024

Background: Renal involvement resulting from hyperuricemia, known as hyperuricemia nephropathy (HN), is characterized by chronic tubulointerstitial inflammation caused by extensive urate crystal deposition. Managing this condition requires straightforward preventive or therapeutic interventions, primarily through dietary measures.

Methods: In this study, the mouse model of HN was established using yeast extract combined with potassium oxonate. The effect and potential mechanism of β‐sitosterol in treating HN were investigated through biochemical indexes, pathological changes, untargeted metabolomics, and network pharmacology.

Results: β‐Sitosterol reduced the levels of four biomarkers of HN: uric acid (UA), creatinine (CRE), blood urea nitrogen (BUN), and xanthine oxidase (XOD). It also mitigated inflammatory injury in renal tissues and reversed the abnormal expression of four key urate transporter proteins: glucose transporter protein 9 (GLUT9), organic anion transporter 1 (OAT1), ATP‐binding cassette transporter G2 (ABCG2), and urate transporter 1 (URAT1). To explore the mechanism of β‐sitosterol in treating HN, this study employed network pharmacology and metabolomics to analyze 27 intersecting gene targets and 14 differential metabolites. The findings indicated that glutathione (GSH) metabolism might be a crucial pathway. Treatment with β‐sitosterol increased the levels of reduced GSH as well as the activity and expression of 6‐phosphogluconate dehydrogenase (G6PDH) in mice, thereby effectively modulating GSH metabolism. This study proposes a novel strategy using β‐sitosterol for treating HN, providing a promising approach for addressing this condition.
Application of Titanium Mesh in the Early Treatment of Flail Chest
Authors: Liu Gaofeng , Zhou Li , Li Chen , Cao Junying , Zhang Yong , Cui Sujuan , Liu Yan , Xu Yanbin , Zang Yongjie , Yang Meiming , Li Qingyuan
Published: November 2024

Objective: To investigate the effect of the titanium mesh on flail chest and bone healing from clinical and animal experiments.

Methods: Clinical experiment: 24 patients with flail chests in our hospital from January 2020 to January 2023 were prospectively selected and divided into control and titanium mesh groups according to different treatment plans and basic data‐matching principles, with 12 cases in each group. The control group was treated with conservative external fixation, and the titanium mesh group was treated with titanium mesh fixation. The clinical efficacy index, visual analog scale and blood gas indexes and hemodynamic indexes of the two groups of patients were recorded. Chest CT and pulmonary function and life quality were examined after operation. Animal experiment: The flail chest sheep were treated conservatively with a titanium mesh, and the expression of bone‐healing‐related proteins was detected.

Results: The mechanical ventilation time, drain indwelling time, ICU observation time, and hospital time in the titanium mesh group were significantly shorter than those in the control group (p < 0.05). The PaO2, CVP, FVC, FEV1, MVV, and life quality of the titanium mesh group were significantly better than those of the control group after operation, and the visual analog scale, PaCO2, CI, ELWI, and the proportions of atelectasis, thoracocyllosis, and consolidation tardive after operation were significantly lower than those of the control group (p < 0.05). The expressions of BMP2, IGF‐1, VEGF, and PDGFD in the rib tissue of titanium mesh sheep were higher than those of control sheep at 4 weeks after operation (p < 0.05).

Conclusion: Titanium mesh is a safe and effective treatment for flail chest, which can improve pain, blood gas, hemodynamic indexes, and pulmonary function and promote fracture healing.
Dysmenorrhea and Occupational Factors
Authors: Jung Heeja , Dan Hyunju , Cha Chiyoung , Pang Yanghee
Published: November 2024

Aim: To examine the prevalence of dysmenorrhea in the predominantly female nursing profession and investigate the role of occupational characteristics in dysmenorrhea.

Background: Studies on working women have mostly examined the effects of dysmenorrhea symptoms on work performance, as opposed to shedding light on the association between work‐related characteristics and dysmenorrhea.

Methods: In this cross‐sectional study, we used data obtained from survey 9 of the Korea Nurses’ Health Study. The participants were female nurses of childbearing age. Statistical analysis included descriptive statistics and multivariable logistic regression.

Results: Data from 6697 participants were analyzed. Of the total sample, 47.3% had dysmenorrhea. After adjusting for confounders to examine the relationship between occupational characteristics and dysmenorrhea, the odds for dysmenorrhea were 1.230 times higher among women who lifted heavy objects at least six times a day compared to those who did not engage in heavy lifting (95% confidence interval: 1.028–1.473) and 1.042 times higher among women with higher physical fatigue (odds ratio: 1.042, 95% confidence interval: 1.023–1.061).

Conclusion: The findings clarify the potential for reducing dysmenorrhea through the improvement of work environment factors. Thus, this study may prove useful for developing educational programs and policies that aim to alleviate dysmenorrhea among working women, including nurses.

Implications for Nursing Management: Nursing managers and health policymakers need to understand the factors influencing dysmenorrhea and minimize female nurses’ physical burden by implementing appropriate nurse–patient ratios and improving their work environment.
Mammographic Density in Relation to Breast Cancer Risk Factors among Chinese Women
Authors: Koka Hela , Tian Yuan , Deng Lu , Yu Kai , Li Er-Ni , Guo Changyuan , Guida Jennifer L. , Sung Hyuna , Chan Ariane , Hu Nan , Lu Ning , Gierach Gretchen L. , Li Jing , Yang Xiaohong R.
Published: November 2024

Background:

Increased mammographic density (MD) is a known breast cancer risk factor, but its influencing factors are unclear in Asian populations. This study examined the links between known breast cancer risk factors and quantitatively measured MD in 7,351 Chinese women with nonmalignant mammographic findings.

Methods:

VolparaDensity software quantified volumetric MD measures: total breast volume (TBV), absolute dense volume (ADV), percent dense volume (PDV = ADV/TBV), and nondense volume (NDV = TBV − ADV). Multivariable linear regression models assessed associations between these MD metrics and breast cancer risk factors.

Results:

The mean age of the population was 50.1 (SD = 8.3) years. The mean ADV, NDV, and PDV were 58.4 cm3 (SD = 32.1), 382.8 cm3 (SD = 202.0), and 14.8 % (SD = 7.1), respectively. PDV was inversely associated with age, weight, body mass index (BMI), parity, breastfeeding duration, and postmenopausal status but positively linked to height and age at menopause. NDV showed opposite associations. ADV had similar associations to PDV, except for height, weight, and BMI, which differed for women with the lowest NDV. PDV associations with age at menarche, age at first birth, and breastfeeding duration varied by BMI and menopausal status.

Conclusions:

MD may influence the relationships between reproductive factors and breast cancer risk, depending on MD measure, menopausal status, and BMI.

Impact:

This study examines how quantitative MD measures relate to known breast cancer risk factors in an East Asian population, factoring in menopausal status and BMI. The results underscore the complex role of MD and confounding factors in breast cancer risk, highlighting the need for tailored insights for future research and screening.
Abstract B038: Application of Liquid Biopsy-RECIST (LB-RECIST) criteria to track metastatic colorectal cancer (mCRC) molecular response in first-line (1L) setting: Findings from the PLATFORM-B study
Authors: Martelli Valentino , Vidal Joana , Fernández-Rodríguez Maria Concepción , García-Alfonso Pilar , Páez David , Gibert Joan , Linares Jennifer , Sibilio Annarita , Alonso Vicente , Cano Maria Teresa , Santos Cristina , Duran Gema , Élez Elena , Manzano José Luis , Garcia-Carbonero Rocio , Ferreiro Reyes , Losa Ferran , Pineda Estela , Sastre Javier , Gomez-España Auxiliadora , Toledo Rodrigo , Rivera Fernando , Bellosillo Beatriz , Tabernero Josep , Salazar Ramon Ramon , Aranda Enrique , Montagut Clara
Published: November 2024

This abstract is being presented as a short talk in the scientific program. A full abstract is printed in the Proffered Abstracts section (PR009) of the Conference Program/Proceedings.

Citation Format: Valentino Martelli, Joana Vidal, Maria Concepción Fernández-Rodríguez, Pilar García-Alfonso, David Páez, Joan Gibert, Jennifer Linares, Annarita Sibilio, Vicente Alonso, Maria Teresa Cano, Cristina Santos, Gema Duran, Elena Élez, José Luis Manzano, Rocio Garcia-Carbonero, Reyes Ferreiro, Ferran Losa, Estela Pineda, Javier Sastre, Auxiliadora Gomez-España, Rodrigo Toledo, Fernando Rivera, Beatriz Bellosillo, Josep Tabernero, Ramon Ramon Salazar, Enrique Aranda, Clara Montagut. Application of Liquid Biopsy-RECIST (LB-RECIST) criteria to track metastatic colorectal cancer (mCRC) molecular response in first-line (1L) setting: Findings from the PLATFORM-B study [abstract]. In: Proceedings of the AACR Special Conference: Liquid Biopsy: From Discovery to Clinical Implementation; 2024 Nov 13-16; San Diego, CA. Philadelphia (PA): AACR; Clin Cancer Res 2024;30(21_Suppl):Abstract nr B038.
Intravenous Dextrose for the Treatment of Neonatal Hypoglycaemia: A Systematic Review
Authors: Roberts Lily F. , Lord Libby G. , Crowther Caroline A. , Harding Jane E. , Lin Luling
Published: November 2024

Introduction: Hypoglycaemic neonates are usually admitted to neonatal intensive care for intravenous (IV) dextrose infusion if increased feeding and dextrose gel fail to restore normoglycaemia. However, the effectiveness of this intervention is uncertain. This review aimed to assess the evidence for the risks and benefits of IV dextrose for treatment of neonatal hypoglycaemia. Methods: Four databases and three clinical trial registries were searched from inception to October 5, 2023. Randomised controlled trials (RCTs), non-randomised studies of interventions, cohort studies, and before and after studies were considered for inclusion without language or publication date restrictions. Risk of bias was assessed using Cochrane’s Risk of Bias 2 tool or Risk of Bias in Non-Randomized Studies of Interventions tool. Certainty of evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation approach. Meta-analysis was planned but not carried out due to insufficient data. Results: Across 6 studies (two RCTs and four cohort), 711 participants were included. Evidence from one cohort study suggests IV dextrose treatment may not be associated with neurodevelopmental impairment at ≥18 months of age (no effect numbers, p > 0.2; very low certainty evidence; 60 infants). Evidence from one RCT suggests IV dextrose treatment may reduce the likelihood of repeated hypoglycaemia (risk ratio [RR]: 0.67 [95% CI: 0.20, 2.18], p = 0.5; low certainty evidence; 80 infants) compared to treatment with oral sucrose bolus. However, the risk of a hyperglycaemic episode may be increased (RR: 2.33 [95% CI: 0.65, 8.39], p = 0.19; 80 infants). Conclusion: More evidence is needed to clarify the benefits and risks of IV dextrose for treatment of neonatal hypoglycaemia.
Prevention of Atopic Dermatitis in Babies by Skin Care from the Newborn Period
Authors: Yuguchi Azusa , Nakajima Takahiro , Ishii Yumi , Yoshino Yukiko , Takahashi Akiko , Endo Kenji , Shiko Yuki , Kawasaki Yohei , Amemiya Ayumi , Torikoe Mihiro , Nakajima Hiroshi , Shimojo Naoki
Published: November 2024

Introduction: So far, no definitive conclusions have been reached regarding the preventive effect of moisturizers on atopic dermatitis (AD). The variability in results may be due to differences in skin care methods, including bathing and washing, among studies and study design. In hot and humid Japan, bathing and gauze washing have been routinely practiced from the neonatal period, but this may impair the skin barrier function. To address this gap, we determined whether a combination of minimally invasive cleaning methods and moisturizing may prevent AD in infants in Japan. Methods: Mothers of children born between January and September 2019 were instructed in traditional skin care methods (control group; 132 subjects), and mothers of children born between January and September 2020 were instructed in a new skin care method combining less invasive washing and moisturizing (intervention group; 140 subjects). Mothers and babies with and without a history of allergy were recruited, and the incidence of AD at 1 year of age was investigated by questionnaire. Results: Skin care-related behaviors such as face washing, hand washing, and use of moisturizers were more frequent in the intervention group than in the control group. At 6 and 12 months of age, there was no difference in the incidence of AD between the two groups. However, for children born between January and March, the prevalence of AD at 12 months was significantly lower in the intervention group than in the control group (2.9% vs. 21.2%, p = 0.0253). Conclusions: This study suggests that for children born during dry and cold seasons, strengthening the skin barrier function early in life through routine skin care with less invasive washing and moisturizing may prevent AD in Japan. Appropriate skin care practices for newborns and infants may vary in regions and environments.
Programa de treinamento físico híbrido sobre a saúde e função física em jovem obeso com síndrome do cromossomo 16: um relato de caso
Authors: Fogagnolo Caroline , Uchida Marco Carlos
Published: November 2024

Introdução: A síndrome no cromossomo 16 é uma desordem gerada por microdeleções de tamanhos variáveis, na região 11.2 deste cromossomo. O fenótipo pode incluir déficit cognitivo, obesidade grave e atraso de neurodesenvolvimento, afetando a qualidade de vida relacionada à saúde. Objetivo: relatar os efeitos de um programa de exercício físico na qualidade de vida e capacidade funcional de um jovem com a síndrome do cromossomo 16. Método: o estudo é um relato de caso, que consistiu em um programa de exercício físico de 20 semanas, com exercícios aeróbios e resistidos, no modelo híbrido (Home-Based Exercise e presencial/supervisionado). Buscou-se informações sobre o participante e foram mensuradas: massa corporal, estatura, circunferências corporais e aplicados os testes Timed Up and Go (TUG) e Five Times Sit-to-Stand Test, (5TSTS), para avaliar da função física, pré e pós-intervenção. A qualidade de vida relacionada à saúde, do jovem e seus cuidadores, foi avaliada por meio do Pediatric Quality of Life Inventory (PedsQL™). Os dados foram analisados com recursos da estatística descritiva. Resultados: o participante foi um adolescente de 14 anos, sexo masculino, inativo fisicamente e com obesidade (índice de massa corporal ~ 65kg/m²). As avaliações não demonstraram alterações morfológicas, entretanto, houve melhora no desempenho dos testes funcionais, sendo 28,5% no TUG e 10,9% no 5TSTS, sugerindo progresso da capacidade funcional. Referente à qualidade de vida, foram observadas modificações favoráveis à melhora dos aspectos social (variação absoluta: 65 pontos), físico e emocional (variação absoluta: 50 pontos em ambos) na percepção do adolescente. No “Módulo de impacto familiar" todos os domínios foram modificados, com exceção para “atividades de vida diária”, destaca-se a “comunicação com outras pessoas” com maior variação. Conclusão: este estudo demonstrou que a prática regular de exercício físico, de forma híbrida, proporcionou resultados positivos na função física, saúde emocional e social do jovem com a síndrome.
Letramento em saúde quanto ao pé diabético e fatores associados em pessoas com diabetes tipo 1 e 2 assistidos pela atenção primária à saúde
Authors: Sousa Árlen Almeida Duarte de , Brito Ana Monique Gomes , Alves Stéfany Allaide Fasolak , Vicente João Victor de Jesus , Martins Andrea Maria Eleutério de Barros Lima
Published: November 2024

Objetivo: identificar os fatores associados a menores níveis de letramento em saúde quanto ao pé diabético entre pessoas com diabetes mellitus atendidas na atenção primária à saúde. Métodos: estudo epidemiológico conduzido entre pessoas com diabetes mellitus tipo 1 e 2 cadastradas em unidades de saúde na cidade de Montes Claros-MG, Brasil. Foram investigadas condições socioeconômicas e demográficas, letramento em saúde quanto ao pé diabético, níveis pressóricos arteriais e risco cardiovascular. Resultados: participaram 282 pessoas com média de idade de 59,53 anos. Menores níveis de letramento em saúde quanto ao pé diabético estiveram presentes em 52,8% (n=149) dos participantes. Associaram-se a menores níveis de letramento em saúde as variáveis idade (OR=2,33; IC95%=1,02-5,31; p=0,045), escolaridade (OR=0,39; IC95%=1,01-2,51; p=0,035) e renda familiar (OR=4,55; IC95%=2,36-8,79; p<0,001). Conclusão: menores níveis de letramento em saúde quanto ao pé diabético estiveram associados aos mais velhos, com menor escolaridade e renda familiar reduzida.
Telangiectasia hereditária familiar: uma causa rara de trombose de porta
Authors: Ponte Filho Antônio Erisvaldo Linhares , Pinheiro Aglaêrton Silva , Lima Rafael Siqueira Athayde
Published: November 2024

Telangiectasia hemorrágica hereditária (THH) é uma doença autossômica dominante que cursa com malformações arteriovenosas que afetam pele, pulmões, cérebro, superfícies mucosas e trato gastrointestinal. A doença se apresenta de diversas formas clínicas como epistaxe, sangramento gastrointestinal e sintomas decorrentes das malformações arteriovenosas cerebrais e pulmonares. A THH confere risco aumentado para tromboembolismo venoso. Apresentamos uma mulher de 57 anos com THH que apresentou epistaxe de repetição, shunt arteriovenoso pulmonar e trombose de porta com transformação cavernomatosa. Ela foi submetida a cauterização nasal, embolização pulmonar, e anticoagulação. A paciente recebeu alta hospitalar com remissão dos sintomas e rivaroxabana oral.
Relação entre estresse oxidativo e COVID-19: uma breve revisão sistemática
Authors: Lobato Micaella Yanne Fender , Borges José Felipe Teixeira , Azevedo Paulo Fábio Lopes , Oliveira Rita de Cássia Silva de
Published: November 2024

OBJECTIVE: Analyse the possible relationship between Oxidative Stress (OS) and the pathogenesis of COVID-19. METHODS: This brief systematic literature review was conducted based on the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). The search resulted in the selection of 10 papers that met the research theme and were published between January 2020 and March 2021. RESULTS: The results revealed that in the course of the disease, there is a decrease in thiol levels and an increase in disulfide and EO, with a probable depletion of antioxidant elements. They found that the accumulation of Reactive Oxygen Species (ROS), added to the damage to albumin, were related to a worse prognosis and that neutrophils may be responsible for the increased level of oxidative stress associated with the worsening of the clinical condition. In addition, cells transfected with the SARS-CoV-2 spike protein showed around three times the concentration of ROS compared to non-transfected control cells. As for serum O2- levels, they were significantly elevated in critically ill patients, constituting a probable predictor of disease severity. CONCLUSIONS: Thus, from the findings of this study, it is possible to infer that both patients with severe and moderate forms of COVID-19 have high EO index values. However, further studies need to be carried out to confirm these preliminary results.
Os direitos morais de integridade e atribuição no Brasil e nos EUA
Authors: Souza Gabriela Biscotto de , Castro João Francisco Chacarosque de
Published: November 2024

Os ordenamentos de tradição jurídica civil-continental (droit d'auteur) e anglo-americana (copyright) apresentam diferenças históricas no tocante à proteção de direitos autorais, especialmente no que diz respeito ao tratamento dado aos direitos morais de autor. No entanto, a distinção entre os dois sistemas não deve ser exagerada. O estudo comparado do regime de direitos morais de integridade e atribuição vigente em dois países (Brasil e Estados Unidos da América), cada qual filiado a um sistema distinto, nos revela algumas das proximidades e diferenças do droit d'auteur e do copyright. Em suma, as duas jurisdições se distinguem: (i) pelos tipos de direitos protegidos; (ii) pela sua duração; (iii) pelos tipos de autora e obra beneficiados com direitos morais; (iv) pelo escopo dos direitos; e (v) pela possibilidade de renúncia.
O direito social à educação: uma análise acerca das medidas alternativas para o ensino remoto no estado da Bahia
Authors: Oliveira Jeiziane da Silva , Santos Maria Priscilla Almeida dos , Ferreira Marilene Conceição
Published: November 2024

No ano de 2020, a propagação do vírus da COVID-19 resultou nas medidas de isolamento social e na suspensão de um ano letivo recém-iniciado. Diante do prolongamento do período pandêmico foram buscadas alternativas para que a educação seguisse como direito público e social. Nesse contexto, através da análise de documentos contidos no site oficial da Secretaria de Educação do Estado da Bahia (SEC-BA), buscamos conhecer quais as medidas empregadas pelo órgão para o retorno às aulas no estado. Verificamos que foram disponibilizadas orientações pautadas nos protocolos preconizados pelos órgãos de saúde, bem como foram feitas adaptações para o ensino remoto, mas em contraste à realidade socioeconômica da população, este não garantiu acesso e permanência, ficando o direito à educação comprometido, apesar do cenário de emergência sanitária.
Luhmann e a Constituição: contributo para uma análise pluricontextual do Estado de Direito
Authors: Berezovsky Pedro Ferreira
Published: November 2024

O presente artigo busca apresentar a compreensão da Constituição enquanto acoplamento estrutural entre o sistema jurídico e o sistema político e aquisição evolutiva da sociedade moderna funcionalmente diferenciada segundo o arcabouço metodológico da Teoria dos Sistemas de Niklas Luhmann. Para tanto, apresenta os fundamentos da interpretação sistêmica e perpassa as funções desempenhadas pela constitucionalização em relação ao Direito e a Política no tratamento de seus paradoxos constitutivos e no desenlace do que se denominam as duas faces da moderna fórmula do Estado Democrático de Direito. Destarte, apresenta uma descrição do fenômeno constitucional como um esquema que possibilita definir duas perspectivas reversas como uma unidade, celebrado como uma conquista ambígua ao promover simultaneamente o agrilhoamento jurídico da força política e a exploração política do direito.
A violência física nas relações conjugais no município de Vitória: uma análise das denúncias da delegacia especializada em atendimento à mulher em 2015
Authors: Carvalho Bruna Passos
Published: November 2024

Gender violence is the result of the social relations of male domination and female submission, built, millenary, by a patriarchal system. From 1980, however, in the fervor of brazilian feminist movements, the Delegacia Especializada em Atendimento à Mulher  (DEAMs) were created with the objective of combating this violence, which can occur in different ways and has become the object of study of research. aimed at improving public policies in the country. Using as a primary source the police reports registered in the DEAM of the city of Vitória in 2015, this article aimed to investigate the relation between the permanence of physical and conjugal violence and a capixaba society molded from patriarchal principles.
Imaginário feminino - A representação das mulheres em Goya: uma análise de “Los Desastres de la Guerra” (cerca de 1810-1815)
Authors: Guidolin Larissa Galende
Published: November 2024

Esse artigo tem como objetivo o estudo das representações das figuras femininas na série de gravuras, Los Desastres de la Guerra, de autoria de Francisco y Lucientes de Goya (1746-1828), produzidas provavelmente entre os anos de 1810 e 1815, no contexto das invasões e da ocupação napoleônica da Espanha e da Península Ibérica. Dentre as oitenta e duas gravuras, poucas estão datadas, tendo sido realizada uma única tiragem de prova durante a vida do artista. A primeira edição completa só viria a público em 1863. Considerando que as gravuras foram confeccionadas no calor dos acontecimentos, busca-se pensar o estatuto documental desse testemunho investigando seus níveis de historicidade. Por intermédio dessas imagens, procura-se explorar o imaginário do artista no que toca às figuras femininas. Interroga-se, igualmente, em que medida tais imagens encarnam as tradicionais alegorias das heroínas das Luzes, sugerindo por um lado a força da resistência ou um comportamento emancipado.
Considerações sobre gênero e sexualidade no Império Otomano (séculos XVI-XIX) e suas potencialidade de análise no Brasil
Authors: Domeneghini Giulianna Girardi , Leitzke Carolina da Silva
Published: November 2024

Este artigo descortina as compreensões de gênero e as práticas de sexualidade no centro do Império Otomano entre os séculos XV e XIX, tendo por objetivo contribuir para mostrar a diversidade de práticas sexuais e demarcações de gênero em diferentes épocas e lugares ao expor aspectos do mundo islâmico pouco conhecidos no Ocidente, particularmente no Brasil. Amparado em fontes especializadas, o artigo busca contribuir para evidenciar que a normatividade dos padrões sexuais é sempre historicamente contextualizada.
Construindo mundos: gênero e museologia em debate
Authors: Belisario Marina
Published: November 2024

O presente artigo refletirá sobre como a prática museológica foi e é afetada pela multiplicação de estudos que contemplam questões de gênero. Tendo como conceito-chave pensamentos concretizados, de Hilde Hein, pretendo afirmar os museus como correlatos das transformações sociais, respondendo às demandas que trazem as novas ideias. Além disso, desenvolvo como um dos propósitos da mencionada instituição a “criação de novos mundos”, partindo do worldmaking de Nelson Goodman.
Fim da noite
Authors: Silva Douglas Alexandre Santos
Published: November 2024

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Abstract 4112589: Typology of Self-Care in Adults with Type 1 Diabetes and Impaired Awareness of Hypoglycemia
Authors: Matus Austin , Matura Lea Ann , Cronholm Peter , Rickels Michael , Riegel Barbara
Published: November 2024

Introduction:
Individuals with type 1 diabetes (T1D) complicated by impaired awareness of hypoglycemia (IAH) are at significantly increased risk for severe hypoglycemia: a marker of high risk of CVD. Tailoring interventions to promote hypoglycemia avoidance is difficult due to self-care heterogeneity among those with T1D.

Aims:
Map self-care heterogeneity among adults with T1D into behavioral phenotypes and identify common barriers to hypoglycemia avoidance within each phenotype.

Methods:
An explanatory sequential mixed methods study was performed in 200 adults with T1D. Participants reported personal, clinical, and social determinants of health, hypoglycemia awareness, and self-care of diabetes (Self-Care of Diabetes Inventory, scored 0-100, adequate ≥70) . Cluster analysis was performed to identify self-care clusters. Then, directed content analysis was applied to individual, semi-structured interviews performed in a subsample from each cluster with IAH (
n
=20). Findings were integrated to develop a typology of self-care and identify barriers to hypoglycemia avoidance within each phenotype.

Results:
Three self-care phenotypes were identified.
Experts
(
n
=70; mean age: 45±17 years; 24% Black; T1D duration: 25±16 years; HbA
1c
: 7.36±1.67%; IAH: 20%) performed all aspects of self-care adequately (Maintenance: 84.9±8.8; Monitoring: 85.1±8.8; Management: 72.5±10). Yet,
Experts
with IAH reported purposefully delaying treatment of hypoglycemia due to lack of concern. Those with
Inconsistent
self-care (
n
= 112; mean age 37±14 years; 20% Black: T1D duration: 21±13 years; HbA
1c
: 7.26±1.16%; IAH: 30%) performed only self-care maintenance adequately (Maintenance: 78.6±8.9; Monitoring: 65.6±9.8; Management: 56.8±10.1). Those with
Inconsistent
self-care and IAH reported passive self-care monitoring that inhibited effective hypoglycemic management.
Novices
(
n
= 18; mean age 27±7 years; 50% Black: T1D duration: 16±8 years; HbA
1c
: 8.97±2.80%; IAH: 28%) reported difficulty performing all aspects of self-care (Maintenance: 51.9±7.7, Monitoring: 56.9±12.9, Management: 44.5±6.3) due to economic and psychosocial barriers.

Conclusions:
Self-care heterogeneity mapped onto three phenotypes that can be used to better understand patient barriers to hypoglycemia avoidance and hypoglycemia awareness restoration. This typology provides a framework for investigating how best to tailor IAH treatment considerate of self-care.
Abstract 4113336: Characteristics and Outcomes of Ventricular Tachycardia Ablation in Patients with the HeartMate 3 Left Ventricular Assist Devices: Results From a Large Single-Center Registry
Authors: Zghyer Fawzi , Tabaja Chadi , Liuba Ioan , Liao Yi-Wen , Younis Arwa , Kochar Arshneel , Lee Justin , Nakhla Shady , Rickard John , Mayuga Kenneth , Finet J. Emanuel , Martin David , Bhargava Mandeep , Chung Mina , Courson Jeff , Sroubek Jakub , Nakagawa Hiroshi , Koeth Robert , Higuchi Koji , Weiss Aaron , Hussein Ayman , Baranowski Bryan , Tang Wai Hong , Dresing Thomas , Callahan Thomas , Taigen Tyler , Kanj Mohamed , Saliba Walid , Soltesz Edward , Wazni Oussama , Starling Randall , Santangeli Pasquale
Published: November 2024

HeartMate 3 (HM3) is a fully magnetically levitated continuous flow left ventricular assist device (LVAD). In patients with HM3 and recurrent ventricular tachycardia (VT), data on the outcomes of catheter ablation (CA) are insufficient. We report our institutional experience with CA of VT in patients with the HM3.Consecutive patients with HM3 and recurrent drug-refractory VT undergoing CA were included. Ablation sites were identified using activation/entrainment mapping (stable VTs) and/or late/fractionated potential ablation and pace-mapping (unstable VTs). Between 2016-2023 a total of 431 patients (age 58±13, INTERMACS 3±0.98, 44% ischemic cardiomyopathy) received an HM3 LVAD at our institution. Of these, 15 (3.4%) underwent CA for recurrent VT despite therapy with 1.3±0.8 antiarrhythmic drugs a median of 700 days from the LVAD surgery (2 patients <1 month from the surgery). The LV access was transseptal in 12 (80%) cases, retrograde aortic in 2 (13%) and both in 1 (7%). A total of 23 distinct VTs were targeted. Of these, 21 (91%) were mapped with activation/entrainment mapping, always utilizing an intracardiac RV reference due to excessive surface ECG noise, and 2 (9%) were hemodynamically unstable with reduced LVAD flows and targeted with substrate-based ablation. A total of 3 (13%) VTs were targeted adjacent to the HM3 inflow cannula, and 20 (87%) from substrate remote from the HM3 cannula. At post-procedural programmed ventricular stimulation, non-inducibility of all targeted VTs was achieved in 13 (87%) patients, 1 patient had residual inducible clinical VT, and in 1 patient no post-procedural programmed stimulation was performed. Periprocedural complications occurred in 1 (7%) case (small pericardial effusion not requiring intervention). At 12 months follow-up following the index procedure, no death occurred and one patient received heart transplantation. Of the remaining 14 patients, 6 (42%) remained free from VT (2 with VT ablation <1 month post-LVAD and 12 with VT ablation >=1 month post-LVAD). In this large single-center HM3 registry, a minority of patients underwent CA for recurrent drug-refractory VT (3.4% over a 7-year period). CA of VT in HM3 recipients is feasible and appears safe also when performed soon after LVAD surgery. Myocardial scar from the underlying cardiomyopathic process rather than the apical cannula is the dominant substrate responsible for VT in these patients.