bluuebunny/crossref_metadata_2025 huggingface dataset:
Multiscale Interactions between Local Short- and Long-Term Spatio-Temporal Mechanisms and Their Impact on California Wildfire Dynamics
Authors: Afolayan Stella , Mekonnen Ademe , Gamelin Brandi , Lin Yuh-Lang
Published: July 2024

California has experienced a surge in wildfires, prompting research into contributing factors, including weather and climate conditions. This study investigates the complex, multiscale interactions between large-scale climate patterns, such as the Boreal Summer Intraseasonal Oscillation (BSISO), El Niño Southern Oscillation (ENSO), and the Pacific Decadal Oscillation (PDO) and their influence on moisture and temperature fluctuations, and wildfire dynamics in California. The combined impacts of PDO and BSISO on intraseasonal fire weather changes; the interplay between fire weather index (FWI), relative humidity, vapor pressure deficit (VPD), and temperature in assessing wildfire risks; and geographical variations in the relationship between the FWI and climatic factors within California are examined. The study employs a multi-pronged approach, analyzing wildfire frequency and burned areas alongside climate patterns and atmospheric conditions. The findings reveal significant variability in wildfire activity across different climate conditions, with heightened risks during specific BSISO phases, La-Niña, and cool PDO. The influence of BSISO varies depending on its interaction with PDO. Temperature, relative humidity, and VPD show strong predictive significance for wildfire risks, with significant relationships between FWI and temperature in elevated regions (correlation, r > 0.7, p ≤ 0.05) and FWI and relative humidity along the Sierra Nevada Mountains (r ≤ −0.7, p ≤ 0.05).
The Preparation and Evaluation of a Hydrochloride Hydrogel Patch with an Iontophoresis-Assisted Release of Terbinafine for Transdermal Delivery
Authors: Li Mengfei , Chen Xinghao , Su Xiangxiang , Gao Wenyan
Published: July 2024

Background: Terbinafine hydrochloride (TEB) is a broad-spectrum antifungal medication commonly used to treat fungal infections of the skin. This study designed a hydrogel patch assisted by an iontophoresis system to enhance the transdermal permeability of TEB, enabling deeper penetration into the skin layers. Methods: The influences of current intensity, pH levels, and drug concentration on the TEB hydrogel patch’s permeability were explored using an adaptive ion electroosmosis system. The pharmacokinetic profile, facilitated by iontophoresis for transdermal permeation, was analyzed through the application of microdialysis technology. Scanning electron microscopy and transmission electron microscopy were employed to assess the impact of ion electroosmotic systems on skin integrity. Results: The cumulative drug accumulation within 8 h of the TEB hydrogel patches, assisted by iontophoresis, was 2.9 and 7.9 times higher than without iontophoresis assistance and TEB cream in the control group, respectively. TEB hydrogel patches assisted by iontophoresis can significantly increase the permeability of TEB, and the AUC(0–8 h) was 3.4 and 5.4 times higher, while the Cmax was 4.2 and 7.3 times higher than the TEB hydrogel patches without iontophoresis, respectively. This system has no significant impact on deep-layer cells. Conclusions: This system may offer a safe and effective clinical strategy for the local treatment of deep antifungal infections.
Development and Geometrical Considerations of Unique Conductive and Reversible Carbon-Nanotube Hydrogel without Need for Gelators
Authors: Ogawa Ryo , Arakaki Ryota , Oya Takahide
Published: July 2024

We propose a new type of CNT hydrogel that has unique conductive and reversible characteristics. We found in previous studies that CNT dispersions became gelatinous without any gelators when a specific CNT was combined with a specific dispersant. This hydrogel has conductive properties derived mainly from the CNTs it contains; and even after gelation, it can be returned to a liquid state by ultrasonic irradiation. Furthermore, the liquid is gelable again. In this study, we prepared several types of CNTs and several types of dispersants, experimentally verified the possibility of gelation by combining them, and geometrically investigated the gelation mechanism to determine how this unique hydrogel is formed. As a result, we found that the experimental results and the theory examined in this study were consistent with the combination of materials that actually become hydrogels. We expect that this study will allow us to anticipate whether or not an unknown combination of CNTs and dispersants will also become gelatinous.
Conductive Polymer-Based Hydrogels for Wearable Electrochemical Biosensors
Authors: Thirumalai Dinakaran , Santhamoorthy Madhappan , Kim Seong-Cheol , Lim Hyo-Ryoung
Published: July 2024

Hydrogels are gaining popularity for use in wearable electronics owing to their inherent biomimetic characteristics, flexible physicochemical properties, and excellent biocompatibility. Among various hydrogels, conductive polymer-based hydrogels (CP HGs) have emerged as excellent candidates for future wearable sensor designs. These hydrogels can attain desired properties through various tuning strategies extending from molecular design to microstructural configuration. However, significant challenges remain, such as the limited strain-sensing range, significant hysteresis of sensing signals, dehydration-induced functional failure, and surface/interfacial malfunction during manufacturing/processing. This review summarizes the recent developments in polymer-hydrogel-based wearable electrochemical biosensors over the past five years. Initially serving as carriers for biomolecules, polymer-hydrogel-based sensors have advanced to encompass a wider range of applications, including the development of non-enzymatic sensors facilitated by the integration of nanomaterials such as metals, metal oxides, and carbon-based materials. Beyond the numerous existing reports that primarily focus on biomolecule detection, we extend the scope to include the fabrication of nanocomposite conductive polymer hydrogels and explore their varied conductivity mechanisms in electrochemical sensing applications. This comprehensive evaluation is instrumental in determining the readiness of these polymer hydrogels for point-of-care translation and state-of-the-art applications in wearable electrochemical sensing technology.
Genome-Wide Identification and Bioinformatics Analysis of the FK506 Binding Protein Family in Rice
Authors: Nie Fanhao , Wang Minghao , Liu Linlin , Ma Xuefei , Zhao Juan
Published: July 2024

The FK506 Binding Protein (FKBP), ubiquitously present across diverse species, is characterized by its evolutionarily conserved FK506 binding domain (FKBd). In plants, evidence suggests that this gene family plays integral roles in regulating growth, development, and responses to environmental stresses. Notably, research on the identification and functionality of FKBP genes in rice remains limited. Therefore, this study utilized bioinformatic tools to identify 30 FKBP-encoding genes in rice. It provides a detailed analysis of their chromosomal locations, evolutionary relationships with the Arabidopsis thaliana FKBP family, and gene structures. Further analysis of the promoter elements of these rice FKBP genes revealed a high presence of stress-responsive elements. Quantitative PCR assays under drought and heat stress conditions demonstrated that genes OsFKBP15-2, OsFKBP15-3, OsFKBP16-3, OsFKBP18, and OsFKBP42b are inducible by these adverse conditions. These findings suggest a significant role for the rice FKBP gene family in stress adaptation. This research establishes a critical foundation for deeper explorations of the functional roles of the OsFKBP genes in rice.
Molecular Mechanisms of Resistance against PSII-Inhibiting Herbicides in Amaranthus retroflexus from the Czech Republic
Authors: Mikulka Jakub , Sen Madhab Kumar , Košnarová Pavlína , Hamouz Pavel , Hamouzová Kateřina , Sur Vishma Pratap , Šuk Jaromír , Bhattacharya Soham , Soukup Josef
Published: July 2024

Amaranthus retroflexus L. (redroot pigweed) is one of the most problematic weeds in maize, sugar beet, vegetables, and soybean crop fields in Europe. Two pigweed amaranth biotypes (R1 and R2) from the Czech Republic resistant to photosystem II (PSII)-inhibiting herbicides were analyzed in this study. This study aimed to identify the genetic mechanisms that underlie the resistance observed in the biotypes. Additionally, we also intended to establish the use of chlorophyll fluorescence measurement as a rapid and reliable method for confirming herbicide resistance in this weed species. Both biotypes analyzed showed high resistance factors in a dose–response study and were thus confirmed to be resistant to PSII-inhibiting herbicides. A sequence analysis of the D1 protein revealed a well-known Ser-Gly substitution at amino acid position 264 in both biotypes. Molecular docking studies, along with the wild-type and mutant D1 protein’s secondary structure analyses, revealed that the S264G mutation did not reduce herbicide affinity but instead indirectly affected the interaction between the target protein and the herbicides. The current study identified the S264G mutation as being responsible for conferring herbicide resistance in the pigweed amaranth biotypes. These findings can provide a strong basis for future studies that might use protein structure and mutation-based approaches to gain further insights into the detailed mechanisms of resistance in this weed species. In many individuals from both biotypes, resistance at a very early stage (BBCH10) of plants was demonstrated several hours after the application of the active ingredients by the chlorophyll fluorescence method. The effective PS II quantum yield parameter can be used as a rapid diagnostic tool for distinguishing between sensitive and resistant plants on an individual level. This method can be useful for identifying herbicide-resistant weed biotypes in the field, which can help farmers and weed management practitioners develop more effective weed control tactics.
Genetic Variants of the Receptor Activator Nuclear of κB Ligand Gene Increase the Risk of Rheumatoid Arthritis in a Mexican Mestizo Population: A Case–Control Study
Authors: Arturo Nava-Valdivia Cesar , Ivan Gamez-Nava Jorge , Betsabe Contreras-Haro , Emilio Perez-Guerrero Edsaul , Yussef Esparza-Guerrero , Alejandra Rodriguez-Jimenez Norma , Tonatiuh Gonzalez-Heredia , Alejandra Villagomez-Vega , Ismael Nuño-Arana , Elena Totsuka-Sutto Sylvia , Manuel Ponce-Guarneros Juan , Heriberto Jacobo-Cuevas , Gerardo Alvarez-Ayala Efren , Laura Gonzalez-Lopez , Miriam Saldaña-Cruz Ana
Published: July 2024

The Receptor Activator Nuclear of κB Ligand (RANKL) plays an important function in immune responses, activating osteoclast cells and unchanged bone resorption, which in turn leads to bone erosion and inflammation. Genetic variants in the promoter region of the RANKL gene could lead to a higher risk of rheumatoid arthritis (RA). Objective: To assess the association of rs9533155 (-693C>G) and rs9533156 (-643T>C) genetic variants with RA risk. Methods: A case–control study was carried out. A total of 94 patients with RA (RA group) and 134 subjects without any rheumatologic disease (control group) were included. Genetic DNA was extracted from peripheral white blood cells (leukocytes). Genetic variant rs9533155 (-693C>G) was screened by an approach based on Polymerase Chain Reaction–Restriction Fragment Length Polymorphism (PCR-RFLP), while rs9533156 (-643T>C) was screened using quantitative polymerase chain reaction (qPCR) with TaqMan probes. RANKL serum levels were measured by ELISA. Results: For rs9533155 (-693C>G), the polymorphic homozygous genotype frequencies (CC) were higher in the RA group (p = 0.006). Individuals carrying the risk genotype presented higher levels of serum RANKL. Carriers of the polymorphic homozygous genotype in the dominant model (CC vs. CG + GG) had an increased risk of developing RA (OR: 1.8, 95% CI 1.04 to 3.1). No association between rs9533156 (-643T>C) and the haplotypes with RA risk was observed. Conclusion: The rs9533155 (-693C>G) genetic variant exhibits a potential role in RA risk. The studied population had no association with the rs9533156 (-643T>C) genetic variant.
Emerging Microorganisms and Infectious Diseases: One Health Approach for Health Shared Vision
Authors: Ristori Maria Vittoria , Guarrasi Valerio , Soda Paolo , Petrosillo Nicola , Gurrieri Fiorella , Longo Umile Giuseppe , Ciccozzi Massimo , Riva Elisabetta , Angeletti Silvia
Published: July 2024

Emerging infectious diseases (EIDs) are newly emerging and reemerging infectious diseases. The National Institute of Allergy and Infectious Diseases identifies the following as emerging infectious diseases: SARS, MERS, COVID-19, influenza, fungal diseases, plague, schistosomiasis, smallpox, tick-borne diseases, and West Nile fever. The factors that should be taken into consideration are the genetic adaptation of microbial agents and the characteristics of the human host or environment. The new approach to identifying new possible pathogens will have to go through the One Health approach and omics integration data, which are capable of identifying high-priority microorganisms in a short period of time. New bioinformatics technologies enable global integration and sharing of surveillance data for rapid public health decision-making to detect and prevent epidemics and pandemics, ensuring timely response and effective prevention measures. Machine learning tools are being more frequently utilized in the realm of infectious diseases to predict sepsis in patients, diagnose infectious diseases early, and forecast the effectiveness of treatment or the appropriate choice of antibiotic regimen based on clinical data. We will discuss emerging microorganisms, omics techniques applied to infectious diseases, new computational solutions to evaluate biomarkers, and innovative tools that are useful for integrating omics data and electronic medical records data for the clinical management of emerging infectious diseases.
Illuminating Genetic Diversity and Selection Signatures in Matou Goats through Whole-Genome Sequencing Analysis
Authors: HuangFu Ruiyao , Li Haobang , Luo Yang , He Fang , Huan Cheng , Ahmed Zulfiqar , Zhang Baizhong , Lei Chuzhao , Yi Kangle
Published: July 2024

(1) Background: Matou goats, native to Hunan and Hubei provinces in China, are renowned for their exceptional meat and skin quality. However, a comprehensive whole-genome-based exploration of the genetic architecture of this breed is scant in the literature. (2) Methods: To address this substantial gap, we used whole-genome sequences of 20 Matou goats and compared them with published genomic data of 133 goats of different breeds across China. This comprehensive investigation sought to assess genetic diversity, population structure, and the presence of genomic selection signals. (3) Results: The whole genome of Matou goat populations yielded a substantial catalog of over 19 million single nucleotide polymorphisms (SNPs), primarily distributed within intergenic and intron regions. The phylogenetic tree analysis revealed distinct clades corresponding to each goat population within the dataset. Notably, this analysis positioned Matou goats in a closer genetic affinity with Guizhou White goats, compared to other recognized goat breeds. This observation was corroborated by principal component analysis (PCA) and admixture analysis. Remarkably, Matou goats exhibited diminished genetic diversity and a notable degree of inbreeding, signifying a reduced effective population size. Moreover, the study employed five selective sweep detection methods (including PI, CLR, PI-Ratio, Fst, and XP-EHH) to screen top signal genes associated with critical biological functions, encompassing cardiomyocytes, immunity, coat color, and meat quality. (4) Conclusions: In conclusion, this study significantly advances our understanding of the current genetic landscape and evolutionary dynamics of Matou goats. These findings underscore the importance of concerted efforts in resource conservation and genetic enhancement for this invaluable breed.
Genome-Wide Identification of APX Gene Family in Citrus maxima and Expression Analysis at Different Postharvest Preservation Times
Authors: Zhang Yu , Peng Yujiao , Zhang Huixin , Gao Qiuyu , Song Fangfei , Cui Xueyu , Mo Fulei
Published: July 2024

Ascorbate peroxidase (APX) is a crucial enzyme involved in cellular antioxidant defense and plays a pivotal role in modulating reactive oxygen species (ROS) levels under various environmental stresses in plants. This study utilized bioinformatics methods to identify and analyze the APX gene family of pomelo, while quantitative real-time PCR (qRT-PCR) was employed to validate and analyze the expression of CmAPXs at different stages of fruit postharvest. This study identified 96 members of the CmAPX family in the entire pomelo genome, with uneven distribution across nine chromosomes and occurrences of gene fragment replication. The subcellular localization includes peroxisome, cytoplasm, chloroplasts, and mitochondria. The CmAPX family exhibits a similar gene structure, predominantly consisting of two exons. An analysis of the upstream promoter regions revealed a significant presence of cis-acting elements associated with light (Box 4, G-Box), hormones (ABRE, TCA-element), and stress-related (MBS, LTR, ARE) responses. Phylogenetic and collinearity analyses revealed that the CmAPX gene family can be classified into three subclasses, with seven collinear gene pairs. Furthermore, CmAPXs are closely related to citrus, pomelo, and lemon, followed by Arabidopsis, and exhibit low homology with rice. Additionally, the transcriptomic heat map and qPCR results revealed that the expression levels of CmAPX57, CmAPX34, CmAPX50, CmAPX4, CmAPX5, and CmAPX81 were positively correlated with granulation degree, indicating the activation of the endogenous stress resistance system in pomelo cells by these genes, thereby conferring resistance to ROS. This finding is consistent with the results of GO enrichment analysis. Furthermore, 38 miRNAs were identified as potential regulators targeting the CmAPX family for post-transcriptional regulation. Thus, this study has preliminarily characterized members of the APX gene family in pomelo and provided valuable insights for further research on their antioxidant function and molecular mechanism.
The Use of an Unmanned Aerial Vehicle (UAV) for First-Failure Landslide Detection
Authors: Mercuri Michele , Biondino Deborah , Ciurleo Mariantonietta , Cofone Gino , Conforti Massimo , Gullà Giovanni , Stellato Maria Carmela , Borrelli Luigi
Published: July 2024

The use of unmanned aerial vehicles (UAVs) can significantly assist landslide detection and characterization in different geological contexts at a detailed scale. This study investigated the role of UAVs in detecting a first-failure landslide occurring in Calabria, South Italy, and involving weathered granitoid rocks. After the landslide event, which caused the interruption of State Road 107, a UAV flight was carried out to identify landslide boundaries and morphological features in areas where there are problems of safe access. The landslide was classified as flow-type, with a total length of 240 m, a maximum width of 70 m, and a maximum depth of about 6.5 m. The comparison of the DTMs generated from UAV data with previously available LIDAR data indicated significant topographic changes across the landslide area. A minimum negative value of −6.3 m suggested material removal at the landslide source area. An approximate value of −2 m in the transportation area signified bed erosion and displacement of material as the landslide moved downslope. A maximum positive value of 4.2 m was found in the deposition area. The landslide volume was estimated to be about 6000 m3. These findings demonstrated the effectiveness of UAVs for landslide detection, showing their potentiality as valuable tools in planning further studies for a detailed landslide characterization and for defining the most appropriate risk mitigation measures.
Longevity as a Responsibility: Constructing Healthy Aging by Enacting within Contexts over the Entire Lifespan
Authors: Morganti Francesca
Published: July 2024

Studying aging now requires going beyond the bio-psycho-social model and incorporating a broader multidisciplinary view capable of capturing the ultimate complexity of being human that is expressed as individuals age. Current demographic trends and the lengthening of life expectancies allow the observation of long-lived individuals in full health. These super-agers are no longer an exception. Indeed, individuals can have a good quality of life even over age 70 and living with chronic or neurodegenerative diseases. This change is driven in part by the cohort effect observed in people who are about to age today (e.g., better schooling, more advanced health conditions, and technologization) but more so by the gradual overcoming of ageist views. An aged person is no longer seen as a quitter but rather as one empowered to direct their own trajectory of potentially healthy longevity. According to this vision, this article proposes a situated lifespan perspective for the study of aging that integrates pedagogical models of developmental ecology with psychological theories of optimal experience to understand the individual motivational perspective on aging. At the same time, it does not disregard analyzing the daily and cultural contexts in which everyone situates and that guide aging trajectories. Nor does it forget that aging people are body-mind (embodied) organisms that, with contexts and through motivations, seize opportunities for action (affordances) to evolve in an optimal way during their lifespan. This theoretical reflection sheds new light on the aging process and on future trends in healthy longevity research.
Metabolism of Fluorinated Topolin Cytokinins in Micropropagated Phalaenopsis amabilis
Authors: Murvanidze Nino , Doležal Karel , Plačková Lenka , Werbrouck Stefaan P. O.
Published: July 2024

Fluorinated cytokinins have emerged as promising alternatives to traditional cytokinins in Phalaenopsis plant tissue culture, offering enhanced stability and bioactivity. However, their metabolic fate and impact on endogenous cytokinin profiles remain largely unexplored. This study builds upon previous research to investigate the comparative metabolism of the traditional cytokinin 6-Benzylaminopurine (BA) with the successful alternatives 6-(3-fluorobenzylamino)purine (FmT) and 6-(3-fluorobenzylamino)purine 9-riboside (FmTR). Additionally, this study examines the impact of another crucial factor, the use of ventilated versus closed containers, on metabolic processes. The results revealed the distinct metabolic profiles associated with each treatment, highlighting the complex interplay between exogenous and endogenous cytokinin levels. This study is the first to investigate the effects of these stable, synthetic, and exogenous cytokinins on the naturally occurring cytokinin levels and their metabolites in micropropagated Phalaenopsis. Additionally, we proposed an alternative inactivation pathway involving the conversion of FmTR and BA to pT and pTR. These findings provide valuable insights into the intricate relationship between cytokinin metabolism and plant growth under in vitro conditions.
Application of Plant Growth Regulators Mitigates Water Stress in Basil
Authors: Silva Dayane Mércia Ribeiro , Marques Isabelly Cristina da Silva , Carvalho Beatriz Lívero , Aires Eduardo Santana , Freitas Júnior Francisco Gilvan Borges Ferreira , Vargens Fernanda Nery , Santos Vinicius Alexandre Ávila dos , Luz João Henrique Silva da , Souza José Wilker Germano de , Oliveira Galdino Wesley de , Sousa Jadielson Inácio de , Melo Alan Fontes , Silva Ricardo Barros , Barbosa Luana do Nascimento Silva , Silva José Vieira , Santos Valdevan Rosendo dos , Góis Maria Gleide Jane Lima de , Paulino Sivaldo Soares , Ono Elizabeth Orika , Rodrigues João Domingos
Published: July 2024

Abiotic stresses, such as water limitation, are significant limiting factors in basil production. One alternative to mitigate the harmful effects of this stress on plants is using plant growth regulators. This study’s objective is to evaluate different doses of plant regulators in basil under water deficiency conditions. A randomized block experimental design in a factorial scheme with two factors was used: the first factor referred to the water regimes of 50% and 100% stomatal conductance, the second to different doses of the plant regulator mixture: 0 mL L−1 (control), 3 mL L−1, 6 mL L−1, 9 mL L−1, and 12 mL L−1. Each treatment consisted of 12 pots per repetition. Biometric parameters, chlorophyll a fluorescence, and gas exchange were analyzed. The plant regulator positively influenced basil plants under water deficiency, with the most pronounced effects observed at the 12 mL L−1 dose: a 17% increase in the number of leaves, a fourfold increase in CO2 assimilation and carboxylation efficiency, and a sevenfold increase in water use efficiency. Therefore, the application of plant regulators on basil is recommended to mitigate the negative effects of water stress, with the most significant results observed at a dose of 12 mL L−1.
Chemical Content and Color of Dried Organic Beetroot Powder Affected by Different Drying Methods
Authors: Tarasevičienė Živilė , Paulauskienė Aurelija , Černiauskienė Judita , Degimienė Aura
Published: July 2024

Preserving vegetable products through drying, which reduces the water concentration to levels inhibiting the growth of microorganisms, is a method to extend their shelf life. Consequently, dried products can be stored for extended periods, mitigating seasonality in some regions. Beetroot roots are a good source of minerals, vitamins, and bioactive compounds, as well as valuable betalain pigments, which consist of red-purple betacyanins and yellow-orange betaxanthins. During processing, the content of betalains decreases because they have insufficient resistance to high temperatures; therefore, color changes occur. Different drying methods were used for beetroot dehydration: conventional drying, vacuum freeze-drying, and spray-drying. The chemical content and physical properties were analyzed. The total phenolic content, as well as betalains, depended not only on the drying method applied but also on the cultivar of beetroots. The phenol content ranged from 2.30 mg GAE g−1 DM in vacuum freeze-dried ‘Scarlet’ beetroot powder to 1.85 mg GAE g−1 DM in conventionally dried ‘Jolie’, as well as ‘Scarlet’, beetroot powder. The predominant betalains in beetroot powder were betacyanins, with the highest content in spray-dried ‘Scarlet’ beetroot powder and the lowest in conventionally dried ‘Kestrel’ beetroot powder. The most significant color changes were observed in spray-dried beetroot powders.
Effect of Cold Plasma Treatment on the Quality of Fresh-Cut Hami Melons during Chilling Storage
Authors: Zheng Heyun , Miao Tenglong , Shi Jie , Tian Mengtian , Wang Libin , Geng Xinli , Zhang Qiuqin
Published: July 2024

Cold plasma (CP) is an alternative to traditional thermal sterilization techniques. This study aimed to investigate the preservation effects of CP treatment at 120 kV and 130 Hz for 150 s on fresh-cut Hami melons during storage at 4 °C for 8 d. There was no significant difference in the pH, color, firmness, and soluble solids content of the two groups during 0–4 days of storage. After CP treatment, the enzyme activities, total viable count (TVC), and values of the electronic nose (E-nose) changed. During storage, the increase in polyphenol oxidase (PPO) and peroxidase (POD) activities was inhibited by CP treatment. Initially, CP treatment yielded a 1.06 log reduction in total viable count (TVC). During storage, the TVC of the CP-treated group was significantly lower than that of the untreated group. CP treatment affected the E-nose values related to ketones, terpenes, polar, aromatic, and sulphur compounds. This study indicated that high-voltage and short-time CP treatment can extend the shelf-life of fresh-cut Hami melons by inhibiting oxidation and reducing microbial contamination without negative effects on physical quality.
Structure Characteristics, Variation of Main Quantitative Traits, and Probability Grading of Chinese Olive (Canarium album) Seeds
Authors: Xie Qian , Jiang Lai , Zhao Qingqing , Zheng Yanju , Yang Yanfei , Chen Qingxi
Published: July 2024

In order to comprehensively describe and evaluate Chinese olive seeds, this study examined 33 varieties (strains) of Chinese olive seeds to address the limitations of previous research on quantitative trait variation and grading among Chinese olive seed varieties (strains). The research specifically focused on evaluating the morphological characteristics, seed locule structure, embryo composition, and phenotypic quantitative traits of Chinese olive seeds. The results indicated that Chinese olive seeds consisted of a core, seed coat, and embryo. Typically, the core contained two to four locules, with each locule containing zero to one embryos. Eight distinct structural variations were identified, with the number of locules per seed ranging from two to four and the number of embryos ranging from one to four. The most common structural types were ‘3-locule 1-embryo’ and ‘3-locule 2-embryo’, each occurring in 100% of the varieties (strains) studied. These two structural types also had a high average proportion within each variety (line), accounting for 50.17% and 42.06%, respectively. The average dimensions of a seed were 31.20 mm in length and 10.89 mm in width, with a shape index of 2.89 and weighing 1.55 g. These quantitative traits displayed significant variation, with the coefficient of variation being highest for single seed weight (19.35%) and lowest for seed length (9.39%). Normality tests revealed that seed width, seed length, and single seed weight followed a normal distribution. These traits were categorized into five levels based on specific points, with probabilities of occurrence approximately 10%, 20%, 40%, 20%, and 10%, respectively. The findings of this study are crucial for understanding and utilizing Chinese olive seed traits and provide valuable insights for the establishment of seed trait standards and data normalization.
Effect of Detraining on Muscle Strength, Functional Capacity, Mental Health, and Body Composition in Individuals with Spinal Cord Injury
Authors: Almada Lucas , Santos Lucas , Freitas Karla , Rodrigues Joel , Diniz Elizângela , Mazini-Filho Mauro , Leitão Luís , Pereira Eveline , Oliveira Cláudia , Moreira Osvaldo
Published: July 2024

Spinal cord injury (SCI) is a condition that significantly affects the quality of life (QoL) of individuals, causing motor, physiological, social, and psychological impairments. Physical exercise plays a crucial role in maintaining the health and functional capacity of these individuals, helping to minimize the negative impacts of SCI. The aim of this study was to evaluate the effect of detraining (DT) (reduction or cessation of physical exercise) during the pandemic on five individuals with thoracic SCI. We assessed muscle strength using strength tests, functional capacity using a functional agility test, mental health using anxiety and depression inventories, and body composition using dual-energy X-ray absorptiometry (DEXA). The results after 33 months of DT showed significant losses in functional agility and MS, as well as a worsening in symptoms of anxiety and depression. It was observed that total body mass and fat mass (FM) exhibited varied behaviors among the individuals. Similarly, the results for lean body mass were heterogeneous, with one participant showing significant deterioration. It is concluded that DT caused by the pandemic worsened the physical and mental condition of individuals with SCI, highlighting the importance of continuous exercise for this population and underscoring the need for individual assessments to fully understand the impacts of DT.
The Potentials of Digital Workplace Health Promotion
Authors: Nöhammer Elisabeth , Drexel Michaela
Published: July 2024

Workplace Health Promotion (WHP) can sustainably impact organizations by improving employee health and strengthening legitimization. Digital Workplace Health Promotion (DWHP) may have even more impact thanks to its scope. This study reports on a hospital in Austria wherein DWPH was introduced into the existing WHP structure in combination with a digitalization effort for the entire organization. The approach was mainly quantitative with a few open questions and included a survey before and an evaluation after the project with about 240 respondents each. The use, intentions, barriers and benefits of DWHP from the employees’ perspectives were reported on to evaluate the potentials of DWHP for furthering sustainable developments within organizations. While DHWP is perceived as positive, current use is low. Nevertheless, intended future use is promising and perceived benefits are higher after implementation. However, perceived barriers are still high, requiring organizational efforts.
Immigrant Older Adults’ Experiences of Aging in Place and Their Neighborhoods: A Qualitative Systematic Review
Authors: Au Alesia , Murad-Kassam Sadaf , Mukanoheli Vestine , Idrees Sobia , Ben Mabrouk Esra , Abdi Khadija , Kennedy Megan , Whitfield Kyle , Salma Jordana
Published: July 2024

Engaging in one’s neighborhood fosters independence, promotes social connectedness, improves quality of life, and increases life expectancy in older adults. There is a lack of evidence synthesis on immigrant older adults’ neighborhood perceptions and experiences, essential for addressing neighborhood-level influences on aging in place. This study systematically synthesizes qualitative evidence on immigrant older adults’ perceptions and experiences of their neighborhoods. A comprehensive search was conducted from inception to 5 April 2023, in multiple databases. This review considered studies including immigrant older adults aged ≥60 years, included studies from any country where the neighborhood was the focus, and only considered qualitative data while excluding review studies, theoretical publications, and protocols. Eligible studies were appraised using the JBI critical appraisal checklist for qualitative research. The Joanna Briggs Institute meta-aggregation approach was used to synthesize findings, and the ConQual approach established confidence in the synthesis. A total of 30 studies were included. Most studies were conducted in North America and explored phenomena such as aging in place, social capital, social cohesion, sense of community, and life satisfaction. Key contextual factors were walkable safe access to social spaces, accessible transportation to amenities, social cohesion with neighbors, and pre-migration neighborhood experiences. Immigrant older adults have varied experiences related to their sense of belonging and social cohesion. Factors such as racial discrimination, feeling unsafe, and social isolation contributed to negative perceptions. This review highlights the need for inclusive neighborhoods that align with the needs and values of immigrant older adults aging in place.
Built Environment and Gender-Based Vulnerability as Key Drivers of Food Insecurity in Allegheny County
Authors: Firestine Alex , Murrell Audrey J.
Published: July 2024

Food insecurity is pervasive in Allegheny County, as one in five residents experiences food insecurity. Food insecurity is linked to chronic health conditions like heart disease and hypertension and disproportionately affects women in the United States, particularly women who are head of household. There are multiple dimensions used to measure regional disparities in food accessibility. Prior research has examined the linkages between food access and food insecurity, and this study aims to explore further the relationship between equitable access to sustainable and affordable food sources. This study examines food outlets in Allegheny County to determine if there is a significant relationship between food outlet availability and food insecurity. Both the presence and accessibility of these food outlets were examined. To measure accessibility, the walking distance to the nearest public transportation stop was calculated for each public transportation stop. The minimum distance to each food outlet was compared to food insecurity rates on a census tract level. Results showed that communities without grocery stores had lower access to healthy and affordable food sources. Also, communities with a higher proportion of female-headed households experienced greater food insecurity, regardless of access to food outlets. There was no statistically significant relationship between the distance from public transportation stops to grocery stores and rates of food insecurity overall and in low-income communities. However, communities with inaccessible grocery stores, either absent in the census tract or without close public transport stops, did have even greater average rates of food insecurity if there was an above-average proportion of female-headed households. Based on these findings, it is evident there exist structural elements of the built environment that correspond with disproportionate rates of food insecurity experienced by communities with households that are predominately female headed. In addition to resource support for these marginalized groups, we suggest that sole reliance on distance as an indicator of food insecurity can be misleading. There should be a greater focus on walkability aggregated on a household or individual level within the community instead of physical distance alone at a general scale.
The Impact of Structural and Meso-Level Factors on Caregiver Coping Abilities When Supporting a Child with Cancer: A Qualitative Study
Authors: Christensen Vivian , Varnum Melissa , Parker Kellee , Chan Lai Hin Kimi , Saxton Lauren , Cottrell Erika
Published: July 2024

Family caregivers of children diagnosed with cancer often experience periods of significant stress. We provide an in-depth examination of the impacts of structural (health care and leave policies) and meso-level (organizations and communities/social networks) factors on caregiver coping during childhood cancer treatment. We conducted a secondary analysis of a comprehensive qualitative dataset examining the impacts of structural and meso-level factors on caregiver coping from in-depth, semi-structured interviews with 49 caregivers representing 38 unique cases of childhood cancer. Using a modified grounded theory approach, transcripts were analyzed using inductive thematic analysis. Caregivers experienced multiple and often intersecting structural and meso-level factors, both facilitating and impeding their ability to cope during their child’s cancer treatment. Our analysis revealed the following themes: having few out-of-pocket medical expenses, access to paid time off from employment, and support from one’s health system, organizations, or community/social networks fostered caregiver coping. Significant financial burdens due to cancer treatment, having to take unpaid leave from employment, remaining employed regardless of one’s circumstances, and lack of support from one’s health system, organizations, or community/social networks hindered caregiver coping. Our findings point to several policies that may ease caregiver burden and facilitate caregiver coping during childhood cancer treatment.
Ecuadorian Provinces with High Morbidity and Mortality Rates Due to Asthma among the Working-Age Population: An Ecological Study to Promote Respiratory Health
Authors: Gómez-García Antonio Ramón , Cevallos Paz Andrea Liseth , Delgado-Garcia Diemen , Jimbo Danilo Martínez
Published: July 2024

Asthma is a significant public health concern. This study identified the provinces with the highest morbidity and mortality rates due to asthma among the working-age population (15–69 years) in the Republic of Ecuador. The secondary objective was to explain the possible differences attributable to occupational exposure. This nationwide ecological study was conducted in 24 provinces between 2016 and 2019. Government databases were used as sources of information. Age-standardized rates were calculated for codes J45 and J46. The hospitalization morbidity rate for asthma decreased from 6.51 to 5.76 cases per 100,000 working-age population, and the mortality rate has consistently been low and stable from 0.14 to 0.15 deaths per 100,000 working-age population. Geographic differences between the provinces were evident. The risk of hospitalization and death due to asthma was higher in the Pacific coast (Manabí with 7.26 and 0.38, Esmeraldas with 6.24 and 0.43, Los Ríos with 4.16 and 0.40, El Oro with 7.98 and 0.21, Guayas with 4.42 and 0.17 and the Andean region (Azuay with 6.33 and 0.45, Cotopaxi (5.84 and 0.48)). The high rates observed in provinces with greater agricultural and industrial development could be national heterogeneity’s main determinants and act as occupational risk factors. The contribution of occupational hazards in each province should be examined in depth through ad hoc studies. The findings presented here provide valuable information that should prompt further detailed studies, which will assist in designing public policies aimed at promoting and safeguarding the respiratory health of the population, particularly that of workers. We believe that this study will inspire the creation of regional networks for the research and surveillance of occupational health.
Unveiling the Heartbeat of Healing: Exploring Organizational Culture in a Tertiary Hospital’s Emergency Medicine Department and Its Influence on Employee Behavior and Well-Being
Authors: D’Silva Roshni , Balakrishnan Jayaraj Mymbilly , Bari Tarushree , Verma Reena , Kamath Rajesh
Published: July 2024

This study examined the organizational culture of an emergency medicine department (EMD) in a tertiary hospital in Karnataka, India, using a prospective cross-sectional design from January to February 2024. It aimed to identify the predominant and supporting organizational cultures within the EMD and their influence on employee behavior and well-being, including job satisfaction, burnout, stress levels, and coping strategies. A total of 82 participants, including physicians, emergency medical technicians, and nurses, completed the Organizational Culture Assessment Instrument (OCAI) and a self-designed questionnaire. Ethical clearance was obtained (IEC2-656). Clan culture emerged as the dominant culture (73.17%), emphasizing collaboration and adaptability, correlated with lower stress levels and high job satisfaction (90.78%). Emotional exhaustion was the most common burnout symptom (53.66%). The coping strategies varied, with employees in Clan cultures seeking social support, while those in Hierarchy cultures sought guidance from superiors. This study highlighted the significant role of organization culture in employee well-being and EMD effectiveness, influenced by social values like respect for authority. The limitations included single-setting analysis, an uneven subgroup representation, and a lack of qualitative insights. Future research should involve multiple hospitals and qualitative methods for a comprehensive understanding.
Ionic Liquids as Green and Efficient Desulfurization Media Aiming at Clean Fuel
Authors: Wang Peng , Wang Rui , Matulis Vitaly Edwardovich
Published: July 2024

With increasingly stringent emission limits on sulfur and sulfur-containing substances, the reduction and removal of sulfur compounds from fuels has become an urgent task. Emissions of sulfur-containing compounds pose a significant threat to the environment and human health. Ionic liquids (ILs) have attracted much attention in recent years as green solvents and functional materials, and their unique properties make them useful alternatives to conventional desulfurization organic solvents. This paper reviews the advantages and disadvantages of traditional desulfurization technologies such as hydrodesulfurization, oxidative desulfurization, biological desulfurization, adsorptive desulfurization, extractive desulfurization, etc. It focuses on the synthesis of ionic liquids and their applications in oxidative desulfurization, extractive desulfurization, extractive oxidative desulfurization, and catalytic oxidative desulfurization, and it analyzes the problems of ionic liquids that need to be solved urgently in desulfurization, looking forward to the development of sulfuric compounds as a kind of new and emerging green solvent in the field of desulfurization.
Network Pharmacology and Transcriptomics to Explore the Pharmacological Mechanisms of 20(S)-Protopanaxatriol in the Treatment of Depression
Authors: Guo Xiangjuan , Su Lili , Shi Meiling , Sun Li , Chen Weijia , Geng Jianan , Li Jianming , Zong Ying , He Zhongmei , Du Rui
Published: July 2024

Depression is one of the most common psychological disorders nowadays. Studies have shown that 20(S)-protopanaxatriol (PPT) can effectively improve depressive symptoms in mice. However, its mechanism needs to be further explored. In this study, we used an integrated approach combining network pharmacology and transcriptomics to explore the potential mechanisms of PPT for depression. First, the potential targets and pathways of PPT treatment of depression were screened through network pharmacology. Secondly, the BMKCloud platform was used to obtain brain tissue transcription data of chronic unpredictable mild stress (CUMS) model mice and screen PPT-altered differential expression genes (DEGs). Gene ontology (GO) analysis and the Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were performed using network pharmacology and transcriptomics. Finally, the above results were verified by molecular docking, Western blotting, and quantitative real-time polymerase chain reaction (qRT-PCR). In this study, we demonstrated that PPT improved depression-like behavior and brain histopathological changes in CUMS mice, downregulated nitric oxide (NO) and interleukin-6 (IL-6) levels, and elevated serum levels of 5-hydroxytryptamine (5-HT) and brain-derived neurotrophic factor (BDNF) after PPT treatment compared to the CUMS group. Eighty-seven potential targets and 350 DEGs were identified by network pharmacology and transcriptomics. Comprehensive analysis showed that transthyretin (TTR), klotho (KL), FOS, and the phosphatidylinositol 3-kinase–protein kinase B (PI3K-AKT) signaling pathway were closely associated with the therapeutic effects of PPT. Molecular docking results showed that PPT had a high affinity for PI3K, AKT, TTR, KL, and FOS targets. Gene and protein level results showed that PPT could increase the expression of PI3K, phosphorylation of PI3K (p-PI3K), AKT, phosphorylation of AKT (p-AKT), TTR, and KL and inhibit the expression level of FOS in the brain tissue of depressed mice. Our data suggest that PPT may achieve the treatment of depression by inhibiting the expression of FOS, enhancing the expression of TTR and KL, and modulating the PI3K-AKT signaling pathway.