bluuebunny/crossref_metadata_2025 huggingface dataset:
Enhancing Florida red tilapia aquaculture: biofloc optimization improves water quality, pathogen bacterial control, fish health, immune response, and organ histopathology across varied groundwater salinities
Authors: Abdel-Rahim Mohamed M. , Elhetawy Ashraf. I. G. , Shawky Wael A. , El-Zaeem Samy Y. , El-Dahhar Alaa A.
Published: July 2024

Freshwater scarcity poses challenges to aquaculture worldwide, including countries like Egypt. In this study, we investigate the feasibility of integrating underground saline water (USW) with varying salinities into a Biofloc (BFT) system for desert mariculture of Florida red tilapia (FRT) and its impacts on water quality, fish performance and health. Four BFT treatments (C/N ratio = 15) were examined in triplicate using four salinity levels 0 ppt, 12 ppt, 24 ppt and 36 ppt, expressed as S0, S12, S24 and S36, respectively. For 75 days, a total of 12 fiberglass tanks (each 250 L−1 water) were used to store FRT fry (average weight of 1.73 ± 0.01 g/fish). The fish were fed an experimental diet (protein/fat = 30/5) and an additional carbon source of rice bran. The results revealed that group S12 showed better growth indicators, higher survival rate, lower FCR, and lower ammonia levels, while group S0 exhibited lower growth indicators (final weight, weight gain, and specific growth rate) than all groups. The serum kidney, liver, and antioxidant indices performed better in the S12 group. At 12 ppt, the immune-related parameter (IgM) increased by 22.5%, while the stress parameter (cortisol) decreased by 40.8% compared to the S0 group. The liver and intestinal histopathological results revealed that the S12 and S24 groups performed better. Pathogenic bacterial load counts favored the S24 group, which had the lowest number among the groups studied. The recommended salinity for FRT cultivation in USW and BFT is 19.94-20 ppt, determined by polynomial regression of FW and FCR.
Serodiagnosis of nasal myasis in camels (Camelus dromedaries) in Egypt using third larval instar affinity-purified glycoprotein
Authors: Aboelsoued Dina , Toaleb Nagwa I. , Mohamed Amany M. , Abdel Megeed Kadria N. , Hekal Sahar Hussein Abdalla
Published: July 2024

The larvae of Cephalopina titillator cause nasopharyngeal myiasis in camels, which parasitize the living tissues of the nasal and paranasal sinuses, pharynx, and larynx. C. titillator infestation adversely affects camel health, meat, and milk production, and can even cause death. In our study, to improve the immunodiagnosis of camel nasal myiasis, a sensitive and specific enzyme-linked immunosorbent assay (ELISA) was developed and evaluated using the Concanavalin-A (Con-A) affinity purification for the C. titillator-N-acetylglucosamine (Ct-GlucNAc) glycoprotein fraction from third larval instars as an antigen for detecting C. titillator antibodies. Crude antigens were prepared from larval instars of C. titillator and evaluated by indirect ELISA. The third C. titillator larval antigen (L3Ct) had the highest protein content (P < 0.001) and the best diagnostic value; chi-square = 235 (P < 0.001). Four glycoprotein fractions were purified separately from the L3Ct antigen by Con-A purification and evaluated. The Ct-GlucNAc glycoprotein fraction was the fraction of choice with the highest diagnostic accuracy (P < 0.05). Using Ct-GlucNAc as a coating antigen, indirect ELISA showed a 99.3% sensitivity for positive results in camel myiasis samples and 100% specificity for negative results in healthy camel samples. The diagnostic accuracy was 99.7%, and no cross reactivity was detected for other parasitic diseases. The indirect ELISA results were confirmed by the western immunoblotting which was characterized by comparing sera from naturally infested dromedary camels with C. titillator, sera from healthy camels and sera from camels with other parasitic infections (Echinococcus granulosus, Fasciola gigantica, Hard ticks; Hyalomma dromedarii, Trichostronglid sp., Eimeria spp., and Cryptosporidium sp.). Immunoreactive antigenic bands of 63, 50, 30 and 18 kDa were predominantly detected in sera from camels with nasopharyngeal myiasis and didn’t react with healthy and camel’s sera from other parasitic infections. However, seven immunoreactive bands appeared at 120, 70, 63, 48, 35, 29, and 19 kDa in the crude L3Ct antigen. In addition, a positive rate of C. titillator immunodiagnosis was detected by indirect ELISA (48.6%, chi-square = 483, P < 0.001), which was significantly greater than that of postmortem diagnosis (31%). In conclusion, the current study introduces a new diagnostic immunoaffinity glycoprotein fraction of C. titillator 3rd larval instar-based ELISA as a highly accurate, simple and fast method to detect specific antibodies of nasal myiasis in camels.
Nuclear-Based Labeling of Cellular Immunotherapies: A Simple Protocol for Preclinical Use
Authors: Volpe Alessia , Lyashchenko Serge K. , Ponomarev Vladimir
Published: July 2024

Labeling and tracking existing and emerging cell-based immunotherapies using nuclear imaging is widely used to guide the preclinical phases of development and testing of existing and new emerging off-the-shelf cell-based immunotherapies. In fact, advancing our knowledge about their mechanism of action and limitations could provide preclinical support and justification for moving towards clinical experimentation of newly generated products and expedite their approval by the Food and Drug Administration (FDA).

Here we provide the reader with a ready to use protocol describing the labeling methodologies and practical procedures to render different candidate cell therapies in vivo traceable by nuclear-based imaging. The protocol includes sufficient practical details to aid researchers at all career stages and from different fields in familiarizing with the described concepts and incorporating them into their work.
Rolling table centrifuge modelling of partially saturated granular material to inform on instability during solid bulk cargo transport
Authors: Kwa Katherine , Gourvenec Susan , Evans Tim , Koseki Junichi , Kishimoto Kenichi
Published: July 2024

The response of partially saturated granular cargoes during maritime transportation has resulted in the capsize and sinking of 27 bulk carriers at sea and the loss over 90 seafarers’ lives in the last decade. The partially saturated granular material response to energy imparted during cargo loading, ship engine vibrations and vessel rolling motions from sea states causes a change in state of the granular cargo, which can lead to vessel instability and ultimately capsize. However, the mechanisms driving the response of partially saturated granular cargos within a bulk carrier hold are not well understood. This paper presents results from an experimental study of rolling table centrifuge model tests on a partially saturated silica sand to contribute to improved understanding of the response of granular cargoes during maritime transport. Observed settlement, pore pressure, moisture content and density changes during and/or following a sequence of large amplitude rolling motions are presented. The results indicate that for the conditions considered, a progressive upwards migration of pore water during rolling led to creation of a free surface of water above the granular sample that was left in a denser, lower moisture content sample compared to its initial state. Sloshing of free water on top of even a competent cargo during rolling motions of the ship can contribute to loss of ship stability and ultimately capsize.
Acquisition of peak bone mass in a Norwegian youth cohort: longitudinal findings from the Fit Futures study 2010–2022
Authors: Sagelv Edvard H. , Emaus Nina , Evensen Elin , Christoffersen Tore , Dennison Elaine , Furberg Anne-Sofie , Grimnes Guri , Johansson Jonas , Nielsen Christopher Sivert , Nilsen Ole Andreas , Winther Anne
Published: July 2024

Summary

In a Norwegian youth cohort followed from adolescence to young adulthood, bone mineral density (BMD) levels declined at the femoral neck and total hip from 16 to 27 years but continued to increase at the total body indicating a site-specific attainment of peak bone mass.

Purpose

To examine longitudinal trends in bone mineral density (BMD) levels in Norwegian adolescents into young adulthood.

Method

In a prospective cohort design, we followed 980 adolescents (473 (48%) females) aged 16–19 years into adulthood (age of 26–29) on three occasions: 2010–2011 (Fit Futures 1 (FF1)), 2012–2013 (FF2), and 2021–2022 (FF3), measuring BMD (g/cm2) at the femoral neck, total hip, and total body with dual x-ray absorptiometry (DXA). We used linear mixed models to examine longitudinal BMD changes from FF1 to FF3.

Results

From the median age of 16 years (FF1), femoral neck BMD (mean g/cm2 (95% CI)) slightly increased in females from 1.070 (1.059–1.082) to 1.076 (1.065–1.088, p = 0.015) at the median age of 18 years (FF2) but declined to 1.041 (1.029–1.053, p < 0.001) at the median age of 27 years (FF3). Similar patterns were observed in males: 16 years, 1.104 (1.091–1.116); 27 years, 1.063 (1.050–1.077, p < 0.001); and for the total hip in both sexes (both p < 0.001). Total body BMD increased from age 16 to 27 years in both sexes (females: 16 years, 1.141 (1.133–1.148); 27 years, 1.204 (1.196–1.212), p < 0.001; males: 16 years, 1.179 (1.170–1.188); 27 years, 1.310 (1.296–1.315), p < 0.001).

Conclusion

BMD levels increased from 16 to 18 years at the femoral and total hip sites in young Norwegian females and males, and a small decline was observed at the femoral sites when the participants were followed up to 27 years. Total body BMD continued to increase from adolescence to young adulthood.
Efficacy of acupuncture in refractory irritable bowel syndrome patients: a randomized controlled trial
Authors: Zhao Jun , Zheng Hui , Wang Xin , Wang Xuefei , Shi Yunzhou , Xie Chaorong , Tao Qingfeng , Li Da , Sun Jingwen , Tian Junjian , Gao Junxia , Liu Huimin , Shi Suhua , Ni Jinxia , Xue Rongdan , Hu Hui , Chen Min , Yu Shuguang , Li Zhigang
Published: July 2024

Previous studies have confirmed that acupuncture for irritable bowel syndrome (IBS) provided an additional benefit over usual care alone. Therefore, we performed a multicenter, randomized, sham-controlled trial to assess the efficacy and safety of acupuncture versus sham acupuncture for refractory IBS in patients in the context of conventional treatments. Patients in the acupuncture and sham acupuncture groups received real or sham acupuncture treatment in 3 sessions per week for a total of 12 sessions. The primary outcome was a change in the IBS–Symptom Severity Scale (IBS-SSS) score from baseline to week 4. A total of 521 participants were screened, and 170 patients (85 patients per group) were enrolled and included in the intention-to-treat analysis. Baseline characteristics were comparable across the two groups. From baseline to 4 weeks, the IBS-SSS total score decreased by 140.0 (95% CI: 126.0 to 153.9) in the acupuncture group and 64.4 (95% CI: 50.4 to 78.3) in the sham acupuncture group. The between-group difference was 75.6 (95% CI: 55.8 to 95.4). Acupuncture efficacy was maintained during the 4-week follow-up period. There were no serious adverse events. In conclusion, acupuncture provided benefits when combined with treatment as usual, providing more options for the treatment of refractory IBS.
SEOM-GG clinical guidelines for the management of germ-cell testicular cancer (2023)
Authors: Arranz Arija José Angel , del Muro Xavier García , Caro Raquel Luque , Méndez-Vidal María José , Pérez-Valderrama Begoña , Aparicio Jorge , Climent Durán Miguel Ángel , Caballero Díaz Cristina , Durán Ignacio , González-Billalabeitia Enrique
Published: July 2024

Testicular germ cell tumors are the most common tumors in adolescent and young men. They are curable malignancies that should be treated with curative intent, minimizing acute and long-term side effects. Inguinal orchiectomy is the main diagnostic procedure, and is also curative for most localized tumors, while patients with unfavorable risk factors for recurrence, or those who are unable or unwilling to undergo close follow-up, may require adjuvant treatment. Patients with persistent markers after orchiectomy or advanced disease at diagnosis should be staged and classified according to the IGCCCG prognostic classification. BEP is the most recommended chemotherapy, but other schedules such as EP or VIP may be used to avoid bleomycin in some patients. Efforts should be made to avoid unnecessary delays and dose reductions wherever possible. Insufficient marker decline after each cycle is associated with poor prognosis. Management of residual masses after chemotherapy differs between patients with seminoma and non-seminoma tumors. Patients at high risk of relapse, those with refractory tumors, or those who relapse after chemotherapy should be managed by multidisciplinary teams in experienced centers. Salvage treatment for these patients includes conventional-dose chemotherapy (TIP) and/or high-dose chemotherapy, although the best regimen and strategy for each subgroup of patients is not yet well established. In late recurrences, early complete surgical resection should be performed when feasible. Given the high cure rate of TGCT, oncologists should work with patients to prevent and identify potential long-term side effects of the treatment. The above recommendations also apply to extragonadal retroperitoneal and mediastinal tumors.
The Silver Lining in the Clouds: A Commentary on Stephen Turner’s “Mad Hazard, a Life in Social Theory”
Authors: Riccioni Ilaria
Published: July 2024

While it is true that to do social theory is to become an observer of life and its development from an outside perspective, it is also true that, in Weberian terms, ethical neutrality cannot disregard experience itself and values as necessary tools for making sense of reality. Indeed, according to Weber, there is no research or social theory without being aware of one’s own values and experience. In this sense, Stephen Turner’s autobiographical book Mad Hazard is great evidence that a scholar’s understanding of social theory is inevitably enriched by an understanding of the life events to which it is related, whereby life experience enhances the ability to grasp the attempt at theorizing in intellectual life, offering the perspective of how that theory observes social reality. Intellectual life and everyday life are necessarily connected. One cannot be fully grasped without the other, but in Weberian terms the autobiography of Stephen Turner can represent precisely the big frame, or statement of values, through which all experiences, bad and good, become the little pieces of the grand picture of this interweaving of practical life and intellectual life, always in continuous reference and making sense from one another.
Contested Understandings of Violence: Refiguring Modern and Postmodern Perspectives
Authors: Coenen Ekkehard
Published: July 2024

There are numerous conceptions of violence today, such as physical, psychological, emotional, structural, and epistemic. The question of which social phenomena are to be described as violence is itself a matter of furious dispute. In social theory, there is a widespread tendency to distinguish between ‘modern’ and ‘postmodern’ conceptions of violence. In this scheme, modern violence is primarily physical, while postmodern violence takes places across a broad spectrum of forms. The paper questions this binary. The co-occurrence and conflict between these forms of violence leads to a third form, which I call refigured violence. The refiguration of violence can be observed in three developments, which are mediatisation, polycontexturalisation, and translocalisation. I provide one illustration of these considerations with the example of so-called shock sites on the internet. In so doing, I emphasise that the sociology of knowledge can provide a valuable perspective for making sense of contemporary discourses about violence in all their complexity.
Quantitative Assessment and Validation of Groundwater Pollution Risk in Southwest Karst Area
Authors: Liu Mei , Huan Huan , Li Haixiang , Liu Weijiang , Li Juan , Zhao Xiaobing , Zhou Aixia , Xie Xianjun
Published: July 2024

Groundwater pollution risk assessment is a useful tool for groundwater pollution prevention and control. However, it is difficult to accurately quantify groundwater flow and contaminant fluxes in karst areas and different types of karst areas have different hydrogeological characteristics. Therefore, the assessment of groundwater pollution risk in karst areas must use different assessment indicator systems. This study developed a new methodology that modified the vulnerability assessment model PLEIK, determined pollutant fluxes considering hydrogeological conditions, and revised parameter weights using the random forest method. The resulting PLEIKD-RF model was used to assess the risk of groundwater contamination in the southwestern karst region and its validity was verified. The results showed that the groundwater pollution risk in the region was low, with 65.64% of the low and relatively low risk areas located in the middle and high mountainous regions. 11.81% of the high and relatively high risk areas were sporadically located in the western and central regions, which were mainly controlled by the distribution of the pollution sources and the karst development. The accuracy of the results of groundwater pollution risk assessment in the study area was 71.87% as verified by the horizontal difference method. The results of the sensitivity analysis indicated that accurate, detailed, and representative data on the protective layer, surface water-groundwater interactions, and pollution source loads would improve the accuracy of groundwater pollution risk zoning. This assessment method provided a reference for similar assessments and the results provide a basis for the protection and management of groundwater resources in the region.
Preoperative intra-aortic balloon pump in patients with ST-elevation myocardial infarction undergoing urgent cardiac bypass surgery
Authors: Hemradj Veemal V. , Spanjersberg Alexander J. , Buitenhuis Marit , Markou Thanasie , Hermanides Rik S. , Dambrink Jan-Henk , Gosselink Marcel , Roolvink Vincent , van Leeuwen Maarten , Ottervanger Jan Paul
Published: July 2024

Background

In patients with ST-elevation myocardial infarction (STEMI), either with or without cardiogenic shock, mechanical circulatory support with an intra-aortic balloon pump (IABP) is not associated with lower mortality. However, in STEMI patients undergoing urgent coronary artery bypass grafting (CABG), preoperative insertion of an IABP has been suggested to reduce mortality. In this study, the effect of preoperative IABP use on mortality in STEMI patients undergoing urgent CABG was investigated.

Methods

All consecutive STEMI patients undergoing urgent CABG in a single centre between 2000 and 2018 were studied. The primary outcome, 30-day mortality, was compared between patients with and without a preoperative IABP. Subgroup analysis and multivariable analysis using a propensity score and inverse probability treatment weighting were performed to adjust for potential confounders.

Results

A total of 246 patients were included, of whom 171 (69.5%) received a preoperative IABP (pIABP group) and 75 (30.5%) did not (non-pIABP group). In the pIABP group, more patients suffered from cardiogenic shock, persistent ischaemia and reduced left ventricular function. Unadjusted 30-day mortality was comparable between the pIABP and the non-pIABP group (13.3% vs 12.3%, p = 0.82). However, after correction for confounders and inverse probability treatment weighting preoperative IABP was associated with reduced 30-day mortality (relative risk 0.52, 95% confidence interval 0.30–0.88).

Conclusion

In patients with STEMI undergoing urgent CABG, preoperative insertion of an IABP is associated with reduced mortality.
The Role of Physical Exercise as a Therapeutic Tool to Improve Lipedema: A Consensus Statement from the Italian Society of Motor and Sports Sciences (Società Italiana di Scienze Motorie e Sportive, SISMeS) and the Italian Society of Phlebology (Società Italiana di Flebologia, SIF)
Authors: Annunziata Giuseppe , Paoli Antonio , Manzi Vincenzo , Camajani Elisabetta , Laterza Francesco , Verde Ludovica , Capó Xavier , Padua Elvira , Bianco Antonino , Carraro Attilio , Di Baldassarre Angela , Guidetti Laura , Marcora Samuele Maria , Orrù Stefania , Tessitore Antonio , Di Mitri Roberto , Auletta Lucia , Piantadosi Angela , Bellisi Mario , Palmeri Edmondo , Savastano Silvia , Colao Annamaria , Caprio Massimiliano , Muscogiuri Giovanna , Barrea Luigi
Published: July 2024

Purpose of Review

This consensus statement from the Italian Society of Motor and Sports Sciences (Società Italiana di Scienze Motorie e Sportive, SISMeS) and the Italian Society of Phlebology (Società Italiana di Flebologia, SIF) provides the official view on the role of exercise as a non-pharmacological approach in lipedema. In detail, this consensus statement SISMeS - SIF aims to provide a comprehensive overview of lipedema, focusing, in particular, on the role played by physical exercise (PE) in the management of its clinical features.

Recent Findings

Lipedema is a chronic disease characterized by abnormal fat accumulation. It is often misdiagnosed as obesity, despite presenting distinct pathological mechanisms. Indeed, recent evidence has reported differences in adipose tissue histology, metabolomic profiles, and gene polymorphisms associated with this condition, adding new pieces to the complex puzzle of lipedema pathophysiology. Although by definition lipedema is a condition resistant to diet and PE, the latter emerges for its key role in the management of lipedema, contributing to multiple benefits, including improvements in mitochondrial function, lymphatic drainage, and reduction of inflammation.

Various types of exercise, such as aquatic exercises and strength training, have been shown to alleviate symptoms and improve the quality of life of patients with lipedema. However, standardized guidelines for PE prescription and long-term management of patients with lipedema are lacking, highlighting the need for recommendations and further research in this area in order to optimise therapeutic strategies.
Of Yeasts and Humans
Authors: Kováč Ladislav
Published: July 2024

Humankind, the biological species Homo sapiens, lives today in a very different world from the one for which it was evolutionarily selected in the geological epoch Pleistocene (2.6 million to twelve thousand years BC). The Anthropocene, as the epoch we live now has been called, is characterized by increasing tension between human nature and technological civilization, and humans live in an atmosphere of uncertainty, insecurity, and threat. By “naturalizing” the human condition, cognitive biology offers the only painless alternative to the many scenarios that depict the extinction of Homo sapiens as a consequence of violent conflicts and unimaginable suffering.
Self-supervised multi-object tracking based on metric learning
Authors: Feng Xin , Liu Yan , Yang Hanzhi , Jiao Xiaoning , Liu Zhi
Published: July 2024

The current paradigm of joint detection and tracking still requires a large amount of instance-level trajectory annotation, which incurs high annotation costs. Moreover, treating embedding training as a classification problem would lead to difficulties in model fitting. In this paper, we propose a new self-supervised multi-object tracking based on the real-time joint detection and embedding (JDE) framework, which we termed as self-supervised multi-object tracking (SS-MOT). In SS-MOT, the short-term temporal correlations between objects within and across adjacent video frames are both considered as self-supervised constraints, where the distances between different objects are enlarged while the distances between same object of adjacent frames are brought closer. In addition, short trajectories are formed by matching pairs of adjacent frames using a matching algorithm, and these matched pairs are treated as positive samples. The distances between positive samples are then minimized for futher the feature representation of the same object. Therefore, our method can be trained on videos without instance-level annotations. We apply our approach to state-of-the-art JDE models, such as FairMOT, Cstrack, and SiamMOT, and achieve comparable results to these supevised methods on the widely used MOT17 and MOT20 challenges.
COVID-19 Led Return to Kerala: A Comparative Analysis of Return Emigrants
Authors: Rajan S. Irudaya , Pattath Balasubramanyam
Published: July 2024

This article concerns emigrants who returned to Kerala between May and December 2020 in the midst of the COVID-19 pandemic. We study and document the experiences of 1985 return emigrants (REM) through a quantitative survey conducted via Computer-Assisted Telephonic Interviews. The study utilises a comparative classificatory framework that categorises return emigrants into three groups: normal REM, distressed REM, and REM who returned to re-emigrate. While the REM have been a demographically, politically, and economically significant component of Kerala’s population, the COVID-19 REM represent a unique case in history that has the potential to not only affect the economy, society, and psyche of Kerala for many years to come, but to also provide valuable insights into the future of global labor migration governance.
The Application of Tannic Acid-Coated Magnetite Nanoparticles for Recovery of Microplastics from the Water System
Authors: Sacko Amoudjata , Nure Jemal Fito , Nyoni Hlengilizwe , Mamba Bhekie , Nkambule Thabo , Msagati Titus A. M.
Published: July 2024

The presence of microplastics (MPs) is rapidly increasing in the environment, posing a significant threat to public health and the ecosystem. To monitor the impact of MPs, it is crucial to have standardized detection methods and MPs remediation techniques. Therefore, this study aimed to use tannic acid-coated magnetite nanoparticles to recover MPs, specifically polystyrene (PS) and polyethylene terephthalate (PET), from water bodies. A facile method for MPs recovery was established using the synthesized tannic acid-coated magnetite (TA-Fe3O4) as an adsorbent. TA-Fe3O4 was synthesized using tannic acid, iron (II) sulfate heptahydrate, and iron (III) chloride hexahydrate through a one-pot co-precipitation method. The adsorbent material was then characterized using a scanning electron microscope coupled with an energy dispersive x-ray spectroscopy (SEM–EDS), x-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, zeta potential, and N2 adsorption–desorption (BET) techniques, confirming its successful synthesis. The maximum adsorption efficiencies for PS and PET were 83% and 98%, respectively, under the experimental conditions of pH 6–7, a contact time of 300 min, an adsorbent dose of 2.5 g/L, and an initial MPs concentration of 1.25 g/L. The study also found that the presence of ions in wastewater had a significant effect on MP recovery. However, when it came to recovering MPs from the spent adsorbent, the maximum values were observed in an acidic medium at pH 3–4 under sonification conditions. In conclusion, TA-Fe3O4 showed potential and efficiency in the recovery of MPs in aqueous media. However, further investigation is needed to improve the method and explore its application for multi-MPs recovery performance.
Love and Organizing in the Context of the Base of the Pyramid: An Integrative Justice Perspective
Authors: Santos Nicholas J.C. , Facca-Miess Tina M.
Published: July 2024

This paper provides an overview of the Integrative Justice Model (IJM) for impoverished populations that was introduced in the marketing literature in the year 2009. The IJM was developed as a normative ethical framework to guide the growing corporate interest in the base of the pyramid (BoP) market to be fair and just to all parties but particularly the impoverished customer. In an impersonal marketplace that often exploits the less advantaged participant, the IJM provides five characteristics of “just” market situations. These are an authentic non-exploitative engagement, value co-creation, investment in future consumption, stakeholder interest representation and long-term profit management. At the heart of the IJM is love that flows from a recognition of the inherent dignity of those at the BoP and the need to respect and uphold that dignity in the marketplace. The hope is that as companies embrace the IJM in their functioning it will result in a marketplace that is fair, just, humanistic and loving.
The impact of the Bank of Japan’s exchange traded fund and corporate bond purchases on firms’ capital structure
Authors: Nguyen Thuy Linh
Published: July 2024

This study examines how the Bank of Japan’s (BOJ’s) exchange-traded fund (ETF) and corporate bond (CB) purchases affect the capital structure of Japanese listed firms. The results first suggest that the BOJ’s ETF purchases reduced the equity risk premium for firms included in the purchases, thereby lowering their cost of equity. These firms issued more stocks and became less dependent on bond debt and bank loans than control firms, resulting in a lower level of leverage. On the other hand, the BOJ’s CB purchases lowered the risk premium of bonds eligible for such purchases, which implies a decline in the cost of bond debt. Firms eligible for CB purchases issued more bonds, while reducing bank debt but to a smaller extent, thus having higher leverage than firms not eligible for CB purchases. Categorizing firms into four groups based on whether their stocks were included in ETF purchases and/or their bonds were eligible for CB purchases further shows that the policy impacts on firm financing have differed depending on which group a firm fell in. These results indicate that the BOJ’s ETF and CB purchases have had a considerable impact on the cost of capital, securities issuance activities, and corporate capital structure.
Sexual dimorphism in the Hungarian golden jackal population: analysing body and skull size and shape
Authors: Csányi Erika , Sándor Gyula
Published: July 2024

Defining species within the Canidae family is challenging due to morphological convergence, behavioral plasticity, traditional taxonomic limitations, and possible hybridisation. This challenge is timely with the recent population and range expansion of the golden jackal (Canis aureus). Exploring their morphological data and sexual dimorphism is essential for identifying factors driving their success in new habitats. The proven hybridization of golden jackals with dogs and wolves may affect species description, population dynamics, and genetic diversity, impacting conservation strategies. This study, for the first time, conducts a morphometric analysis of golden jackals in Somogy County, Hungary, to prove sexual size dimorphism (SSD) in body and skull and sexual shape dimorphism (SShD) in skull across juvenile and adult age groups. 719 golden jackals (362 females and 357 males) were collected between January 2021 and January 2023. Descriptive statistics revealed significant SSD in body and skull measurements among both age groups, with males generally larger than females, particularly in body mass (11.72% in juveniles and 13.37% in adults). Most skull dimensions differed significantly between sexes and age groups, except for foramen magnum height, foramen magnum width, and postorbital breadth among juveniles and foramen magnum height and postorbital breadth among adults. We used principal component analyses (PCA) on raw dimension data and the log shape ratio method to extract shape information. Linear discriminant analysis (LDA) explored skull SShD between sexes. Notably, our study achieved over 71% accuracy in sex classification, illustrating the clear presence of SShD of the skull in golden jackals across both age groups. Our study provides a comprehensive database of golden jackals in the overpopulated Hungarian habitat, which will be helpful for further research on ecology, behavior, and conservation management.
New trends in microbial gums production, patented technologies and applications in food industry
Authors: Martínez-Burgos Walter José , Ocán-Torres Diego Yamir , Manzoki Maria Clara , Scapini Thamarys , de Mello Ariane Fátima Murawski , Pozzan Roberta , Medeiros Adriane Bianchi Pedroni , Vandenberghe Luciana Porto de Souza , Soccol Carlos Ricardo
Published: July 2024

The market for microbial gums such as xanthan, gellan, dextran, and curdlan is continuously expanding, driven by their increasing application in various industries including petroleum, pharmaceuticals, cosmetics, and food, with the latter accounting for approximately 50% of global usage. To meet the growing demand and improve sustainability, there is a need to enhance production efficiency and reduce costs. This article addresses these issues by examining recent advancements and emerging trends in microbial gum production and application. By highlighting patented technologies and innovative approaches, the article aims to provide a comprehensive understanding of how the industry can achieve higher yields and economic viability. Despite being produced by different microorganisms, these gums are synthesized under similar conditions, such as pH, temperature, and medium composition. The purification or downstream processes for these gums are also comparable, primarily involving solvent precipitation, centrifugation for separation, and drying. Significant advances in gum production include genetic improvement of microbial strains to improve biopolymer performance. Additionally, alternative media are being explored, either by optimizing nutrient availability or deprivation, or by using agroindustrial by-products to reduce production costs. Engineering improvements are another strategy: bioreactor characteristics, fermentation conditions and modes of operation, and advances in downstream process are highlighted. Furthermore, the text explores emerging trends in the application of microbial gums in the food sector. Microbial gums applications are not limited to their traditional action as emulsifiers and stabilizers, but expands to new uses in biodegradable packaging films and as antioxidant and prebiotic food ingredient.
From the Editor
Authors: Kidder Robert L.
Published: July 2024

The longer I serve as editor, the more frustrated I feel at turning down good or promising manuscripts. Whether there has been a change in my own standards or a change in submissions, my overall impression is that I have had to turn away an increasing number of high quality papers. I have dealt with this by reducing the type size in volume 22 and exceeding the page limits by a bit. The result in this issue should be obvious just by the feel of it—it is longer.
Hidden Large Aerosol‐Driven Cloud Cover Effect Over High‐Latitude Ocean
Authors: Wang Xin , Mao Feiyue , Zhu Yannian , Rosenfeld Daniel , Pan Zengxin , Zang Lin , Lu Xin , Liu Fan , Gong Wei
Published: July 2024

Understanding how aerosols affect cloud cover is critical for reducing the large uncertainty of the aerosol‐cloud interaction (ACI). The 2014 Holuhraun effusive eruption in Iceland resulted in a significant increase in cloud drop number concentration (Nd) relative to the climatological Nd observed during periods of relatively infrequent volcanic activity. Previous studies show a significant “Twomey” effect during this eruption; however, aerosol‐induced changes in cloud fraction (Cf) appeared negligible. This leads to the question of why changes in aerosols do not cause Cf changes. To address this question, prediction models were derived to predict Cf based on Nd and meteorological parameters. These validated models allow us to investigate aerosol perturbations on Cf in various Nd scenarios by controlled meteorological conditions. Here our analysis unveiled that the increase in Nd was primarily observed under polluted conditions where Nd surpassing the threshold of 60 cm−3. After this point, cloud cover stops increasing even as Nd increases. On the contrary, the cloud cover did increase by 9.0% under conditions of clean backgrounds (Nd < 60 cm−3). Accordingly, the aerosol‐driven cloud adjustment is hidden behind the seemingly insignificant cloud cover effect in areas with large background Nd. These findings provide insights into the importance of considering background Nd and the saturation status of cloud covers in ACI studies.
Insights Into Urban Heat Island and Heat Waves Synergies Revealed by a Land‐Surface‐Physics‐Based Downscaling Method
Authors: Xue Lingbo , Doan Quang‐Van , Kusaka Hiroyuki , He Cenlin , Chen Fei
Published: July 2024

Researchers have recently focused on the interplay of the urban heat island (UHI) effect and heat waves (HWs). However, the synergies of these two phenomena remains inconclusive at present. To address this gap, this study investigated UHIs and HWs synergies during the last 30 years in the Tokyo metropolitan area, through a unique and novel approach named Land‐Surface‐Physics‐Based Downscaling (LSP‐DS). LSP‐DS integrates the widely used Noah‐Multiparameterization (Noah‐MP) land‐surface model coupled with urban canopy‐process physics, aiming to conduct high‐resolution, long‐term urban‐specific simulations with much less computational resources. Our comprehensive analysis combining observation data and numerous LSP‐DS simulations confirms exacerbated UHIs during HWs. Specifically, HWs amplify the temperature differences between urban and rural environments, which is quantified by UHI intensity (UHII). During HWs, UHII increased more at night in inland areas and more during daytime in coastal areas. HWs present especially a heightened threat to coastal regions where daytime UHII increased by approximately 1°C during HWs. The Bowen ratio can explain the increase in the daytime UHII, and the daytime accumulated storage heat increase during HWs can explain the increase in nighttime UHII. Based on future projections of the increasing frequency of high temperatures, our findings highlight the impending heat‐related health challenges faced by urban residents.
Separating Common Signal From Proxy Noise in Tree Rings
Authors: McPartland M. Y. , Dolman A. M. , Laepple T.
Published: July 2024

Tree rings are the most widely‐used proxy records for reconstructing Common Era temperatures. Tree‐ring records correlate strongly with temperature on an interannual basis, but studies have found discrepancies between tree rings and climate models on longer timescales, indicating that low‐frequency noise could be prevalent in these archives. Using a large network of temperature‐sensitive tree‐ring records, we partition timeseries variance into a common (i.e., “signal”) and non‐climatic (i.e., “noise”) component using a frequency‐resolved signal‐to‐noise ratio (SNR) analysis. We find that the availability of stored resources from prior years (i.e., biological “memory”) dampens the climate signal at high‐frequencies, and that independent noise reduces the SNR on long timescales. We also find that well‐replicated, millennial‐length records had the strongest common signal across centuries. Our work suggests that low‐frequency noise models are appropriate for use in pseudoproxy experiments, and speaks to the continued value of high‐quality data development as a top priority in dendroclimatology.
Energy Conversion in the Dip Region Preceding Dipolarization Front
Authors: Zhao B. N. , Liu C. M. , Cao J. B. , Liu Y. Y. , Xing X. N.
Published: July 2024

Dipolarization fronts (DFs), characterized by sharp increases in the northward magnetic field and usually preceded by magnetic dips, are suggested to play an important role in energy conversion and transport in the magnetotail. It has been documented that strong energy conversion typically develops right at the fronts. Here we present spacecraft observations of electron‐scale energy conversion (EEC) developed inside the dip region ahead of a DF, by using high‐cadence data from the Magnetospheric Multiscale Mission. The EEC, with magnitude comparable to that at the front, is primarily driven by ion current and electron‐scale electric field. The electric field inside the dip is provided by electrostatic waves fed by lower hybrid drift instability, which experiences temporal decaying. Such decaying leads to nonhomogeneity of EEC along the dawn‐dusk direction. These results, uncovering a new channel for DF‐driven energy conversion, can provide important insights into understanding energy transport in the magnetotail.
Whistler‐Mode Waves on Density and Magnetic Shelves
Authors: Nejad Salman A. , Streltsov Anatoly V.
Published: July 2024

This study presents a recent finding of magnetic shelf structures and packages of whistler‐mode waves in the data obtained from the Magnetospheric Multiscale (MMS) mission satellite in the equatorial magnetosphere. These observations are compared with the waves observed on density shelves by the NASA Van Allen Probes (aka RBSP) mission. By employing simulations of the electron‐MHD model, we explain that similar to the density shelf ducting, magnetic shelves effectively guide whistler‐mode waves along the ambient magnetic field with little attenuation. The parameters of the guided waves depend on the parameters of the shelves. We discuss the similarities and differences of the wave guided by the density and magnetic field shelf‐like structures. The simulations successfully reproduce the parameters of the observed waves.
Stress Field Dynamics and Fault Slip Potential in the Paradox Basin
Authors: Dvory N. Z. , McLennan J. D.
Published: July 2024

The Paradox Basin, straddling Utah, Colorado, Arizona, and New Mexico is characterized by an intricate amalgamation of evaporites and clastic layers and is dominated by prominent salt walls and related subsurface structures. Our research offers a new examination of the stress distribution across the basin, deriving from continuous and discrete stress measurements conducted in boreholes in the region and focal mechanism analysis, emphasizing variations over salt structures. Integrating Coulomb failure criteria with probabilistic methods, we assess potential fault movements resulting from fluid pressure alterations. Our approach provides a comprehensive understanding of the Paradox Basin's state of stress, showing a continuous change of the maximum horizontal stress orientation from N‐S at the Wasatch Fault Zone to WNW‐ESE in the northern part of the Paradox Basin and to WSW‐ENE in the southern part of the basin. Further East, into the Colorado Plateau and the Uncompahgre Uplift, the SHmax orientation becomes E‐W. Decoding stress orientation dynamics has enabled critical insights into fault slip potential, especially in the basin's northern region. The salt wall faults are less likely to slip, and the Paradox Formation's evaporite and clastic rock sequence can serve as a potential low seismic risk target for carbon storage and hydrocarbon extraction.
The impact of obesity on chronic oedema/lymphoedema of the leg – an international multicenter cross-sectional study (LIMPRINT)
Authors: Burian Ewa Anna , Rungby Jørgen , Karlsmark Tonny , Nørregaard Susan , Cestari Marina , Franks Peter J. , Moffatt Christine Joy
Published: July 2024

Background/Objectives

Obesity and chronic oedema/lymphoedema are two distinct but related conditions, rarely investigated together. The aim was to study the impact of increased weight on chronic oedema and related factors.

Subjects/Methods

A cross-sectional study, 38 centers, nine countries. Patients with clinically confirmed chronic oedema/lymphoedema of the leg were included. Weight category was estimated as: normal weight (BMI 20–30), class I-II obesity (BMI 30–40), or class III obesity (BMI > 40). Factors were tested for an association with increased weight, using a multivariable model.

Results

A total of 7397 patients were included; 43% with normal weight, 36% class I-II obesity and 21% class III obesity. Increased weight was associated with more advanced stages of chronic oedema (ISL stage III; the most advanced form); affecting 14% in normal weight, 18% class I-II obesity and 39% class III obesity (p < 0.001). Ten factors were independently associated with increased weight: diabetes (OR 2.4), secondary lymphoedema (OR 2.7), cellulitis/erysipelas within 12 months (OR 1.2), bilateral lymphoedema (OR 3.6), compression therapy (OR 2.1), increased swelling duration (1–2 years OR 1.3, 2–5 years OR 2.5, 5–10 years OR 3.6, >10 years OR 3.5) decreased mobility (walking with aid OR 1.9, being chair bound OR 1.2) and age (reference<45 years; 45–64 years OR 1.5, 75–84 years OR 0.6, 85+ years OR 0.2). Increased weight was associated with a lower presentation of peripheral arterial disease (OR 0.7) and poorer chronic oedema control (OR 0.8). Patients with obesity had lower function, appearance and more severe symptoms (LYMQOL) and lower quality of life (EuroQol).

Conclusions

Obesity negatively impacts chronic oedema, leading to more advanced stages. Achieving good control of swelling with compression is more difficult in these patients. Increased awareness of chronic oedema/lymphoedema as a complication of obesity is important for early detection and for developing effective strategies to prevent and manage them.
Semaphorin 3C (Sema3C) reshapes stromal microenvironment to promote hepatocellular carcinoma progression
Authors: Peng Hao , Yang Meng , Feng Kun , Lv Qingpeng , Zhang Yewei
Published: July 2024

More than 90% of hepatocellular carcinoma (HCC) cases develop in the presence of fibrosis or cirrhosis, making the tumor microenvironment (TME) of HCC distinctive due to the intricate interplay between cancer-associated fibroblasts (CAFs) and cancer stem cells (CSCs), which collectively regulate HCC progression. However, the mechanisms through which CSCs orchestrate the dynamics of the tumor stroma during HCC development remain elusive. Our study unveils a significant upregulation of Sema3C in fibrotic liver, HCC tissues, peripheral blood of HCC patients, as well as sorafenib-resistant tissues and cells, with its overexpression correlating with the acquisition of stemness properties in HCC. We further identify NRP1 and ITGB1 as pivotal functional receptors of Sema3C, activating downstream AKT/Gli1/c-Myc signaling pathways to bolster HCC self-renewal and tumor initiation. Additionally, HCC cells-derived Sema3C facilitated extracellular matrix (ECM) contraction and collagen deposition in vivo, while also promoting the proliferation and activation of hepatic stellate cells (HSCs). Mechanistically, Sema3C interacted with NRP1 and ITGB1 in HSCs, activating downstream NF-kB signaling, thereby stimulating the release of IL-6 and upregulating HMGCR expression, consequently enhancing cholesterol synthesis in HSCs. Furthermore, CAF-secreted TGF-β1 activates AP1 signaling to augment Sema3C expression in HCC cells, establishing a positive feedback loop that accelerates HCC progression. Notably, blockade of Sema3C effectively inhibits tumor growth and sensitizes HCC cells to sorafenib in vivo. In sum, our findings spotlight Sema3C as a novel biomarker facilitating the crosstalk between CSCs and stroma during hepatocarcinogenesis, thereby offering a promising avenue for enhancing treatment efficacy and overcoming drug resistance in HCC.