bluuebunny/crossref_metadata_2025 huggingface dataset:
A computational method to differentiate rheumatoid arthritis patients using thermography data
Authors: Pauk Jolanta , Trinkunas Justas , Puronaite Roma , Ihnatouski Mikhail , Wasilewska Agnieszka
Published: November 2021

BACKGROUND: The traditional rheumatoid arthritis (RA) diagnosis is very complicated because it uses many clinical and image data. Therefore, there is a need to develop a new method for diagnosing RA using a consolidated set of blood analysis and thermography data. OBJECTIVE: The following issues related to RA are discussed: 1) Which clinical data are significant in the primary diagnosis of RA? 2) What parameters from thermograms should be used to differentiate patients with RA from the healthy? 3) Can artificial neural networks (ANN) differentiate patients with RA from the healthy? METHODS: The dataset was composed of clinical and thermal data from 65 randomly selected patients with RA and 104 healthy subjects. Firstly, the univariate logistic regression model was proposed in order to find significant predictors. Next, the feedforward neural network model was used. The dataset was divided into the training set (75% of data) and the test set (25% of data). The Broyden-Fletcher-Goldfarb-Shanno (BFGS) and non-linear logistic function to transformation nodes in the output layer were used for training. Finally, the 10 fold Cross-Validation was used to assess the predictive performance of the ANN model and to judge how it performs. RESULT: The training set consisted of the temperature of all fingers, patient age, BMI, erythrocyte sedimentation rate, C-reactive protein and White Blood Cells (10 parameters in total). High level of sensitivity and specificity was obtained at 81.25% and 100%, respectively. The accuracy was 92.86%. CONCLUSIONS: This methodology suggests that the thermography data can be considered in addition to the currently available tools for screening, diagnosis, monitoring of disease progression.
Cortical activity, kinematics and trunk muscles activity response to pelvis movements during unstable sitting
Authors: Aleknaite-Dambrauskiene Ieva , Domeika Aurelijus , Zvironas Arunas
Published: November 2021

BACKGROUND: Balance control is a leading component of human motor activities and its impairment is associated with an increased risk of falling, lower back pain due to impaired motor control mechanism. Prolonged sitting position at workplace is one of the risk factors of reduced postural control and lower back pain. OBJECTIVE: To evaluate theta and alpha waves cortical activity, trunk muscles activity and kinematics in static sitting, dynamic sitting on different platforms: simple wobble board (WB) and wobble board on bearing surface (WBB). METHODS: The kinematics of body segments, electromyography of five trunk muscles, electroencephalography of 32 scalp electrodes were measured during balance tasks in sitting position for 17 subjects with continuous seated position at workplace. RESULTS: Cortical power on WBB1 increase in fronto – central (p< 0.05) region while on WBB2 increase in centro – parietal region (p< 0.05). WBB2 increase more muscles compared with WB2. The amplitude of movement of ASIS, Th10 can be seen lower on WBB compared with WB (p< 0.05). CONCLUSIONS: The study shows that WBB can increase personalized sitting and improve trunk motor control during hours of prolonged sitting.
An effect of spinal and ankle-foot orthoses on gait of spastic diplegic child: A case report
Authors: Ziziene Jurgita , Daunoraviciene Kristina , Juskeniene Giedre , Pauk Jolanta
Published: November 2021

BACKGROUND: In children with spastic cerebral palsy (CP), the most common motor dysfunction is pathological gait. OBJECTIVE: To evaluate the effectiveness of measures for an individual CP case. METHODS: The case of one spastic diplegia child has been analyzed. Both lower extremities and spine were examined under three gait conditions: 1) barefoot, 2) with ankle-foot orthoses (AFOs) and thoracolumbosacral spinal orthosis (TLSO), and 3) with TLSO only. Spatiotemporal gait and kinematic parameters of the pelvic, hip, knee, ankle joints, and spine were obtained using Vicon Plug-in-Gait model. The difference (Δ) between the measured values and normative ranges was calculated to determine the efficiency of the orthoses. RESULTS: Significant differences were found in kinematic and spatiotemporal parameters comparing results between conditions and body sides. The effectiveness of the measures was confirmed by the smallest Δ values in the double and single support time with the AFOs/TLSO and in the stride and stance time with TLSO. CONCLUSIONS: Based on the study results, the best stability of the spine, ankle plantarflexion, and knee hyperextension is achieved with the AFOs/TLSO; therefore, this combination of measures was considered the most effective. However, not only quantitative parameters should be taken into account, but also the child’s willingness and comfort.
2D numerical investigations derived from a 3D dragonfly wing captured with a high-resolution micro-CT
Authors: Stelzer Vera , Krenkel Lars
Published: November 2021

BACKGROUND: Due to their corrugated profile, dragonfly wings have special aerodynamic characteristics during flying and gliding. OBJECTIVE: The aim of this study was to create a realistic 3D model of a dragonfly wing captured with a high-resolution micro-CT. To represent geometry changes in span and chord length and their aerodynamic effects, numerical investigations are carried out at different wing positions. METHODS: The forewing of a Camacinia gigantea was captured using a micro-CT. After the wing was adapted an error-free 3D model resulted. The wing was cut every 5 mm and 2D numerical analyses were conducted in Fluent® 2020 R2 (ANSYS, Inc., Canonsburg, PA, USA). RESULTS: The highest lift coefficient, as well as the highest lift-to-drag ratio, resulted at 0 mm and an angle of attack (AOA) of 5∘. At AOAs of 10∘ or 15∘, the flow around the wing stalled and a Kármán vortex street behind the wing becomes visible. CONCLUSIONS: The velocity is higher on the upper side of the wing compared to the lower side. The pressure acts vice versa. Due to the recirculation zones that are formed in valleys of the corrugation pattern the wing resembles the form of an airfoil.
Quantitative assessment of the level of instability of a single-plane balance platform
Authors: Gudziunas Vaidotas , Domeika Aurelijus , Puodžiukynas Linas , Gustiene Renata
Published: November 2021

BACKGROUND: Balance training on unstable surfaces is widely used in medicine and sports. The main disadvantage of balance platforms is weakly definable assessment of the level of instability (IL) they create. OBJECTIVE: To evaluate the mechanical characteristics of a suspended single-plane instability balance platform which determines quantitative instability characteristics. METHODS: Three criteria influencing the IL were evaluated: 1. The displacement of the platform board by changing the position of the object on the board; 2. Amount of force required for board displacement; 3. The vibration damping of the platform. RESULTS: 1. 1IL the displacement of the object on the board affected 0.66 cm. the displacement of the board relative to the platform frame; 2IL – 0.79 cm; 3IL – 0.91 cm.; 2. A force of 2.64 is required for a board displacement of 1IL compared to 2IL and 5.76 times that of 3IL. 3. Damping factor 1IL – 0.015, 2IL – 0.006, 3IL – 0.003. CONCLUSIONS: 1. The longer the suspension, the change in the position of the object on the board affects the greater movement of the board relative to the platform. 2. Different IL can be compared with each other depending on how different the force required to cause the board to move. 3. The platform dampens vibrations weakly, but the damping between 1 and 3 IL differs about 5 times.
A secure encryption method of communication channel based on cloud computing technology
Authors: Wu Weiwei
Published: November 2021

The traditional channel encryption method is interfered by noise signal, which leads to long encryption time and poor security. This paper proposes a communication channel security encryption method based on cloud computing technology. In order to obtain the minimum benefits of the same channel and orthogonal channel in the frequency conversion receiver, the dual input and dual output model is constructed; the influence of time domain and frequency domain on the transmission signal is analyzed, and the nonlinear transmission characteristics of the channel signal are obtained. Through cloud computing technology, the channel transmission characteristics are divided into dynamic parameters and static parameters to realize the key distribution of communication channel under cloud computing technology; the balance factor is used to provide the key for the sorted generators to realize the secure encryption of communication channel. The results show that the average error probability of the proposed method is about 0.275, and the signal-to-noise ratio is between 115 and 118 SNR.
Multi-Scale Pseudo-Bending Raytracing for Arbitrary Complex Media
Authors: Huan-Lan Zhang , Bao-Li Wang
Published: November 2021

Raytracing is a fast and effective numerical simulation method of the seismic wavefield. It plays an important role in field data acquisition design, wavefield analysis, identification, and tomography. In raytracing, pseudo-bending (PB) is a fast and efficient method, but it is unsuitable for complex media with sudden velocity changes. An improved pseudo-bending raytracing method is presented in this paper, which can be applied to any complex medium. The proposed method first decomposes complex medium into multi-scale velocity components and then applies the pseudo-bending approach to the velocity components of different scales. The numerical simulation of seismic wavefield from models shows that the improved multi-scale pseudo-bending (MSPB) method can be applied to a medium with continuous velocity variation and any complex medium with abrupt velocity change.
Avaliação de bovinos nelore e mestiços curraleiros em sistema de semiconfinamento
Authors:   Universidade Iguaçu, Andrade João Fernando Soares , Ragazzi Fernanda Giácomo ,   Universidade Iguaçu
Published: November 2021

The objective of this work was to evaluate the productive efficiency in feed conversion and weight gain of two groups of animals used in the region of the State of Minas Gerais. Thus, it was intended to demonstrate through descriptive analyzes, the best yield of beef production in relation to its maintenance in the farm in a semiconfinement breeding system, carried out. Two groups of animals were separated from different blood grades, the Nellore breed and the crossbred mestizos. For the analyzes, the comparisons before and after the semiconfinement were carried out, as well as annotations of warm carcass weight, weight gain on days of semiconfinement and economic evaluation. Within the criteria to characterize the best investment, nellore presented better carcass yield, less time to gain weight and higher economic income.
Pembentukan posyandu remaja di Desa Bejiruyung, Kecamatan Sempor Kabupaten Kebumen
Authors: Rahmadhani Wulan
Published: November 2021

Masa remaja adalah masa peralihan antara anak-anak dan dewasa. Remaja masa kini mengahadapi tuntutan dan harapan, juga bahaya dan godaan yang lebih banyak dan kompleks. Apabila masalah itu tidak tertangani dengan baik bisa berdampak kepada masa depan serta berdampak pada kesehatan psikologisnya. Salah satu pencegahan bisa berupa keberadaan posyadu remaja yang dapat meningkatkan pengetahuan remaja. Tujuan dari pengabdian masyarakat ini adalah membentuk posyandu remaja dan kader remaja di desa Bejiruyung, Kecamatan Sempor Kabupaten Kebumen. Metode yang di lakukan pada pengabdian masyarakat ini adalah pelatihan kader posyandu yang di awali dengan persiapan yang di mulai dengan komitmen kepada remaja desa Bejiruyung, Kecamatan Sempor, Kabupaten Kebumen. Selanjutnya adalah pelaksanaan, antara lain penyuluhan dan pelatihan selama 2 kali yang meliputi materi dan praktek. Hasil dari kegiatan pengabdian masyarakat ini adalah telah terbentuknya Fresh Beji (Forum Remaja Sehat Desa Bejiruyung). Kesimpulan dari kegiatan pengabdian masyarakat ini adalah remaja di Desa Bejiruyung sangat antusias pada saat mengikuti kegiatan serta mereka menyebutkan bahwa kegiatan ini sangat bermanfaat untuk remaja
IbM “PENDEKKAR BIMA” (Pendidikan Kesehatan Kader Dan Remaja Berbasis Masyarakat ) sebagai penguatan kinerja melalui pelatihan pemeriksaan darah di Posyandu Jambu Desa Bogoran
Authors: Estri Belian Anugrah
Published: November 2021

Kegiatan ini memaparkan hasil pelaksanaan Iptek bagi Masyarakat (IbM) dalam bentuk pendidikan kesehatan kader dan remaja berbasis masyarakat ) sebagai penguatan kinerja  melalui pelatihan pemeriksaan  darah di posyandu jambu desa Bogoran. Tujuan program  ini menumbuhkan kepedulian remaja dalam kesehatan di masyarakat salah satunya kesehatan lansia, serta menggerakkan peran aktif dan mandiri dari kader lansia dalam pemeriksaan darah kolestrol, asam urat, dll. Target Luaran yang dihasilkan adalah 10 peserta pelatihan yang terdiri remaja pkk dan kader posyandu lansia yang telah aktif dalam mengikuti pelatihan pemeriksaan darah kolesterol, asam urat, glukosa darah dan hb. Diharapkan dengan partisipasi aktif ini akan menumbuhkan semangat kader dalam memberikan pelayanan di masyarakat serta membentuk kemandirian kader dalam deteksi dini penyakit yang sering dialami lansia. Sebagai tindak lanjut dari kegiatan ini diharapkan mampu memberikan pelayanan dengan baik dan mandiri dalam peningkatan kesehatan lansia, serta melalui etos kerja  kader MAU belajar dan harus MAMPU melakukan peningkatan kesehatan di masyarakat salah satunya dengan ketrampilan pemeriksaan darah ini.
COMPARATIVE EVALUATION OF EFFICACY OF SCALING AND ROOT PLANING WITH AND WITHOUT CHLORHEXIDINE CHIP AND DIODE LASER IN CHRONIC PERIODONTITIS PATIENTS
Authors: Shree Reya , Dahiya Varun , Shukla Pradeep , Kataria Prerna , Dagar Mona
Published: November 2021

Introduction: The motive of the present study is to comparatively measure the competence and effectiveness of diode laser and chlorhexidine chip as adjuncts to the scaling and root planing procedure, in patients with chronic periodontitis.

Aim: To evaluate the efficacy of diode laser and chlorhexidine chip before and after scaling and root planing in the management of chronic periodontitis. The objective is to compare the efficacy of chlorhexidine chip and diode laser before and after scaling and root planning on clinical parameters.

Study and design: Randomized clinical trial with split mouth design done in the Department of Periodontics and Implantology.

Materials and methods: Twenty chronic periodontitis patients having a probing pocket depth of 5mm-7mm on at least one interproximal site in each quadrant of the mouth were selected in the study. After initial treatment, four sites in each patient were randomly subjected to scaling and root planing (control), chlorhexidine chip application (CHX chip group), diode laser (810 nm) decontamination (Diode laser group) or combination of both (Diode laser and chip group). All subjects received a clinical periodontal examination by single examiner who recorded all the variables by manual procedure. Clinical parameters namely Plaque index (PI), Gingival Index (GI), probing pocket depth (PPD) and clinical attachment level (CAL) were assessed at baseline, one month and three months. Results were statistically analysed using one-way ANOVA followed by Post Hoc Analysis.

Results: The differences in PPD reduction and CAL gain between control group and CHX chip and combination groups were statistically significant (p<0.05) at three months, whereas, the diode laser group did not show any significant difference from the control group.

Conclusion: Within the limitations in the present study, the following conclusions were derived, i.e., chlorhexidine local delivery alone or in combination with diode laser decontamination is effective in improving oral hygiene, reducing gingival inflammation, reducing probing pocket depth and improving clinical attachment levels when used as adjuncts to scaling and root planing in non-surgical periodontal therapy of patients with chronic periodontitis.

Keywords: Diode laser decontamination, Local drug delivery, Scaling and root planing.
Efektifitas Hypnopregnancy Terhadap Peningkatan Kualitas Tidur Ibu Hamil
Authors: Maya Raden Ayu Aminah , Rosmiarti Rosmiarti
Published: November 2021

Latar Belakang: Selama kehamilan, tubuh ibu hamil mengalami perubahan besar yang bias membuat ibu hamil seringkali merasa tidak nyaman, baik itu perubahan fisiologis maupun psikologis. Perubahan ini menimbulkan gejala spesifik sesuai dengan tahapan kehamilan yang terdiri dari tiga trimester. Perubahan psikologis yang sering terjadi pada ibu hamil seperti kecemasan/ stress. Dampak kecemasan yang lain adalah dapat menurunkan kualitas dan kuantitas tidur ibu hamil selama masa kehamilan Terapi non farmakologi yang   dapat dilakukan meliputi relaksasi,guided imagery, progressive   muscle   relaxation,  hipnoterapi dan terapi music klasik. Tujuan: Penelitian ini untuk mengetahui efektifitas hypnopregnancy dalam meningkatkan kualitas tidur ibu. Metode: penelitian ini adalah penelitian quasi eksperiment dengan bentuk rancangan perbandingan kelompok statis (Static Group Comparison) dan menggunakan uji statistik chi square. Data didapatkan dari wawancara melalui lembar observasi langsung dengan instrument The Pittsburgh Sleep Quality Index (PSQI). Sampel penelitian ini berjumlah 30 orang yang terdiri dari kelompok eksperimen dan kontrol. Hasil:uji statistik, diperoleh tingkat signifikansi ρ<0.05 (ρ: 0.009), yang berarti ada pengaruh yang signifikan antara hypnopreganncy terhadap kualitas tidur ibu hamil.Kesimpulan:hypnopregnancy dapat digunakan sebagai salah satu terapi untuk memperbaiki dan meningkatkan kualitas tidur ibu.
FMCG-RETAIL BUSINESS MODEL IN THE GLOBAL COMPETITIVE ENVIRONMENT OF THE KNOWLEDGE ECONOMY
Authors:   Vasyl’ Stus Donetsk National University, Huzenko Anastasiia
Published: November 2021

The article analyzes the period of functioning of FMCG-retail in the global competitive environment of the knowledge economy. Retail purposefully influences the market environment and the dynamics of economic development, contributing to the spread of economic and cultural globalization, strengthening close world economic ties, defining market guidelines for producers, competitors and consumers, and vice versa, the global competitive environment of the knowledge economy dictates in the market, therefore in the given work the estimation of the basic factors of influence of the global competitive environment of knowledge economy on the world market of FMCG-retail was carried out. The aim of the article is to develop and substantiate a new business model of FMCG-retail in a global competitive environment of the knowledge economy. The study revealed the transformation of the business model into the following components: factors of influence, key partners, resources, actions, core values, sales channels, methods of communication, key customers, which in turn leads to changes in the structure of costs and revenues. The new model emphasizes the need to create demand, not just to meet existing market needs. Digital transformations in Ukraine affect changes in the business model in several aspects. In the case of FMCG-retail, digital transformation includes digitization of operations, such as automation of logistics processes and tracking of customers’ movement on the site, digitization of supply chains, is automated location search and omnichannel development. In turn, the classic marketing of promotion and branding in a global competitive environment of the knowledge economy becomes ineffective, it is replaced by intelligent marketing, which involves changing the approach to standard operations and processes – such as electronic price tags or geolocation services for personalized offers. The changes concern such a component of the business model as basic resources, the main focus is already shifting to human capital, which produces innovative technological solutions for business development, which brings increasing turnover. All these trends destroy the traditional boundaries of retail trade, and have a significant impact on the multi-channel business model, changing it dramatically.
ANALYSIS OF INNOVATIVE TYPES OF VOLATILITY (FLEXIBLE) TRADE ENTREPRENEURSHIP
Authors:   Mukachevo State University, Korolovych Oksana , Ponevach Attila ,   Mukachevo State University
Published: November 2021

With courses on volatility and flexibility as complementary categories, modern trade has led to several innovative models of trade entrepreneurship. These types of models are oriented towards specific basic elements and combinations of them, among them: trading platforms, temporary trading centers, support systems. These elements form the entrepreneur’s schemes for providing services to clients before, during, and after the exchange of goods for innovative types of variable (or flexible) business models. These models are new in trade, especially the novelty is characteristic for the variables and flexible trading platforms of their cells, among them pop-up, showroom, outlets/delivery points. The specific formation and operation of trade points also need to be tested. The article analyzes innovative types of models of variable or flexible trade entrepreneurship, in particular: the specificities of trade points in business innovation models are highlighted; the specificities of their trading platforms and support systems are highlighted. Following the peculiarities and available schemes of the entrepreneur in providing services to clients before, during, and after the exchange, we state that the model of variable and flexible trade entrepreneurship is formed only with this combination of trading platforms, Trade points, and their support systems, providing: Under the peculiarities and available schemes of the entrepreneur in providing services to clients before, during and after the exchange, we state that the model of variable and flexible trade entrepreneurship is formed only with this combination of trading platforms, trade points, and their support systems, providing: Flexibility of the trading platform, in terms of timing, location, cost management; maximum latitude, flexibility (variability) of the trade choice (that is highly specialized) personalization of the entrepreneur’s scheme of providing services to clients before, during and after the exchange, sometimes the customization of a sentence. Further prospects in this direction lie in specifying the factors for increasing the efficiency of trade entrepreneurship in Ukraine through variable (flexible) models.
Prospettive della discriminazione qualitativa tra redditi di lavoro
Authors: Canè Daniele
Published: November 2021

La discriminazione qualitativa consiste nel trattamento differenziato di redditi, il cui possesso manifesta diversa capacità contributiva in ragione della fonte patrimoniale. Concorre dunque ad assicurare, più che derogare, all'uguaglianza tributaria. Poiché l'apprezzamento delle situazioni che esprimono capacità contributiva spetta al legislatore, nel limite della ragionevolezza della differenziazione e della coerenza della relativa disciplina, i vincoli più stringenti alla discriminazione qualitativa non sono di ordine costituzionale, bensì dipendono dalla struttura dell'imposta sul reddito. Le possibilità di discriminazione qualitativa tra redditi di lavoro sono dunque limitate nell'Irpef.
La tassazione dei redditi delle donne ed il principio di uguaglianza tributaria: la leva impositiva per la realizzazione e promozione dell'equità fiscale di genere
Authors: Iacobellis Luigi
Published: November 2021

In uno scenario mondiale aggravato dalla situazione pandemica e caratterizzato dall'acuirsi delle disuguaglianze, il tema delle differenze di genere assume un ruolo di assoluta centralità. Analizzati i principali elementi del gender gap e del differenziale retributivo di genere, anche in ragione dei più recenti studi ed analisi statistiche, nel contributo si è inteso indagare in diritto la possibilità di introdurre una tassazione di vantaggio per le donne, nel rispetto dei limiti imposti dal diritto unionale, dai fondamenti del sistema tributario italiano e dal principio di uguaglianza tributaria sancito dalla nostra Carta costituzionale. De jure condendo vengono valutate le possibili strategie, funzionali anche al quadro post-pandemico, che l'ordinamento tributario potrà adottare per il raggiungimento di una equità fiscale di genere, illustrando potenzialità e criticità della leva impositiva per ridurre e contrastare il gender gap attraverso una rimodulazione del sistema di tassazione dei redditi delle donne.
Le riforme del sistema di imposte e benefici in discussione dopo la pandemia da covid-19
Authors: Maitino Maria Luisa , Ravagli Letizia , Sciclone Nicola
Published: November 2021

Il sistema italiano di imposte e benefici è da sempre oggetto di riforme. Attualmente, sono in discussione interventi di modifica dell'imposta sul reddito delle persone fisiche e delle politiche di sostegno alle famiglie con figli. Durante la pandemia è tornato, inoltre, in auge il dibattito sull'introduzione di un'imposta patrimoniale, anche come mezzo per finanziare gli interventi a sostegno delle famiglie colpite dagli effetti economici del Covid-19. In questo lavoro è analizzato, attraverso un modello di microsimulazione fiscale, l'impatto di gettito e distributivo delle principali proposte di riforma in discussione. I risultati mostrano che una riforma dell'Irpef, aderente agli obiettivi che si è posto il legislatore, ridurrebbe l'imposizione sulle classi di reddito medio ma al contempo la capacità redistributiva dell'imposta. L'assegno unico e universale per i figli potrebbe avere effetti distributivi positivi mentre una patrimoniale avrebbe un valore simbolico di contrasto alle disuguaglianze.
L'eco dell'esperienza sul nostro sapere
Authors: Saita Emanuela
Published: November 2021

In questo commento si sostiene l'idea che la conoscenza specifica di ciascuna disciplina che si occupa della cura della salute si debba collegare ad altre forme di conoscenza, affinché la scienza possa effettivamente essere di aiuto in sfide complesse come l'attuale pandemia e pos-sa rispondere a futuri incerti che caratterizzano il nostro tempo.
I tanti problemi della transdisciplinarità
Authors: Di Nuovo Santo
Published: November 2021

Dopo una discussione sul termine transdisciplinarità, vengono esposti alcuni problemi che si pongono nelle sue applicazioni, specie alla psicologia della salute. I problemi per perve-nire ad un sistema senza confini stabili fra le discipline sono di tipo sia epistemologico che me-todologico, ma anche organizzativi dei protocolli di ricerca-azione e della interazione fra gli attori sociali. Viene presentato un esempio di ricerca transdisciplinare, relativo alla prevenzione della demenza. Questo tipo di ricerca costituisce una sfida per tutte le scienze della salute, e in particolare per la psicologia.
Tratti di personalità e stili di coping in soggetti con diagnosi di fibromialgia
Authors: Iacolino Calogero , Isgrò Rachele , Lombardo Ester Maria Concetta , Ferracane Giuseppina , Cervellione Brenda
Published: November 2021

La fibromialgia è una sindrome dal dolore cronico diffuso caratterizzata da numerosi sin-tomi. Ad un campione di 233 soggetti fibromialgici (M = 45.7, DS = 11.7) residenti in Italia e prevalentemente donne (97.4% femmine e 2.6% maschi) è stata somministrata una batteria di test comprendente: un questionario socioanagrafico costruito ad hoc, un test per valutazione dei tratti di personalità (PID-5-BF) e uno per gli stili di coping (COPE). Dai risultati è emerso un profilo di personalità caratterizzato prevalentemente da Affettività Negativa, Distacco e Psicoticismo. I valori medi degli stili di coping non si discostano signifi-cativamente da quelli del campione normativo e, la presenza di specifici tratti di personalità ri-sulta predire determinate strategie di coping. In conclusione, la conoscenza del profilo personologico, delle modalità di fronteggiare la situazione stressante e il tipo di relazione che intercorre fra i due costrutti rappresenta un'utile informazione in termini clinici, affinché anche la figura dello psicologo possa giocare un ruolo essenziale nell'intervento multidisciplinare al paziente affetto da fibromialgia.
Genere, salute e migrazione: analisi delle determinanti sociali di salute e del benessere autopercepito delle donne migranti, attraverso i dati dell'European Social Survey e del Migration Integration Policy Index
Authors: Vesco Silvia , Mancini Tiziana , Rossi Michele
Published: November 2021

Lo studio si propone di analizzare le determinanti psico-sociali della salute dei migranti in Europa e delle donne migranti in particolare, all'interno della cornice teorica degli studi sull'acculturazione. Le determinanti di salute sono state analizzate su due livelli: individuale, attraverso dati raccolti dall'European Health Interview Survey nel 2014 (EHIS wave 2) con un campione pari a 15.244 persone, e contestuale, attraverso indicatori quali il Migration Integra-tion Policy Index (Mipex), l'Euro-barometro sulle discriminazioni, il Gender Equality Index (GEI), il Prodotto Interno Lordo (Gross Domestic Product) e la percentuale di migranti sul totale della popolazione riferiti agli anni 2014 e 2015 su 24 paesi EU. I risultati emersi hanno confermato uno svantaggio in termini di salute per le donne migranti, le quali sono soggette a discriminazioni molteplici che impattano sullo stato di salute.
E-prescribing: the rise of socio-tech-med micronetworks of care during the COVID-19 pandemic
Authors: Murero Monica
Published: November 2021

The present paper critically investigates the rise of e-prescribing socio-tech-med micronetworks of health care in Northern Italy and the role of innovative caregivers. Based on semi-structured one-to-one discursive interviews, this study's results show that e-prescribing innovative practices modify four domains: 1) introduce techno-care fluctuating dynamics, 2) modify spaces and time barriers to care, c) build socio-tech-med micro-networked connections, and d) create innovative "technological" carers. The interdigital carer may support distinctive forms of techno-based senior care in Italy, diffuse e-prescribing culture, and transmediate health objects and services. Careful planning and human-tailored decisionmaking are necessary to normalize e-prescribing socio-tech-med practices and avoid digital health inequalities in pandemic and post-pandemic scenarios.
Vulnerability and resilience of the European health care systems in the face of the Covid-19 pandemic: a framework for the comparative analysis of problematic sentinel cases
Authors: Giarelli Guido
Published: November 2021

The main results in terms of inter-regional and intra-regional variations of the application of the concept of "health macro-region" are presented in the first part of the article in order to show how the European health care systems have differently coped with the COVID-19 outbreak. Given the high levels of intra-regional variation found, it seemed appropriate to also add an analysis by country in order to identify those "sentinel cases", given their alert value, which recorded the worst ratio between the infection rates (cases/population) and the lethality rates (deaths/cases). In order to explore the possible reasons behind the problematic coping with the pandemic of these "sentinel cases", a conceptual framework for the analysis of vulnerability, resilience and their governance in terms of sustainability of health care systems is developed in the second part, hoping its application could represent a useful contribution for best-practice solutions that could guide the management of future pandemics.
Sosiomateriaalinen näkökulma vuorovaikutukseen muuttuvissa työtiloissa
Authors: Kuismin Ari
Published: November 2021

Työelämään ja organisaatioihin ovat viime vuosina vaikuttaneet monet eri muutokset. Yksi voimakkaimmista muutoksista koskee sitä, missä töitä tehdään eli työnteon tiloja. Tutkimuksissa on tarkasteltu muun muassa tilojen roolia ihmisten välisen vuorovaikutuksen edistämisessä, työntekijöiden oppimisen tukemisessa sekä inklusiivisuuden ja monimuotoisuuden vahvistamisessa. Viime aikoina huomiota on kiinnitetty erityisesti siihen, miten tilat vaikuttavat ihmisten toimijuuteen eli kykyyn ja mahdollisuuksiin toimia tai vaikuttaa erilaisiin työhön liittyviin tilanteisiin. Tässä puheenvuorossa keskityn siihen, miten tilojen ja ihmistoimijuuden välistä suhdetta voidaan tutkia niin kutsutusta sosiomateriaalisesta näkökulmasta erityisesti organisaatioiden ja muuttuvan työelämän kontekstissa. Esitän, että parempi ymmärrys tilojen vaikutuksesta ihmistoimijuuden muotoutumiseen on keskeinen osa tasa-arvoisemman, oikeudenmukaisemman ja sosiaalisesti kestävämmän työelämän rakentamista tilanteessa, jossa lähes kaikki yhteiskunnan tilat voidaan nähdä mahdollisina tietotyön tiloina.
Therapies to Increase ApoA-I and HDL-Cholesterol Levels
Authors: Brown William M. , Chiacchia Fabrizio S.
Published: November 2021

Abstract non disponibile
In Silico Molecular Characterization of Cysteine Protease YopT from Yersinia pestis by Homology Modeling and Binding Site Identification
Authors: Hasan Md. Anayet , Alauddin S. M. , Al Amin Mohammad , Nur Suza Mohammad , Mannan Adnan
Published: November 2021

Abstract non disponibile
THE EFFECTIVENESS OF VACCINATION AGAINST THE NEW CORONAVIRUS INFECTION (COVID-19) IN THE KRASNOYARSK TERRITORY
Authors: Mironova A. A. , Narkevich A. N. , Shesternya P. A.
Published: November 2021

Introduction: Vaccination is considered to be the most important measure to control the pandemic of the new coronavirus infection COVID-19. This article attempts to present the results of vaccination campaign against COVID-19 during a six-months period in the Krasnoyarsk Territory. The aim: To assess the effectiveness of vaccination against COVID-19 infection among adults in the Krasnoyarsk Territory. Methods: We used population-based data from the Federal Register of Infected with COVID-19 on COVID-19 cases in the Krasnoyarsk Territory and the Federal Register of Vaccinated against COVID-19 by July 30, 2021. Differences in mortality, proportions of patients who need in-hospital treatment, proportions of patients in extremely serious and serious conditions, proportions of patients who required artificial ventilation and hospitalization in intensive care between vaccinated and non-vaccinated, as well as immunized and non-immunized COVID-19 patients were calculated. Results: Those who were vaccinated (regardless of the timing of the disease after vaccination) and those who were immunized (42 days after the introduction of the first component of the vaccine) were significantly less likely to suffer from COVID-19 (14.6 patients per 1 000 vaccinated and 16.8 per 1 000 immunized versus 116.9 patients per 1 000 unvaccinated and 112.1 per 1 000 non-immunized, respectively), and in the case of the disease after vaccination, there is a much lighter course of disease with a lower proportion of cases requiring hospitalization (18.3 % versus 24.5 %) or treatment in intensive care units (0.8 % versus 1.6 %), artificial ventilation (0.6 % versus 1.3 %) and low case fatality(2.1 % versus 3.3 %). Conclusion: The study provides the evidence on less severe course of COVID-19 among vaccinated and immunized individuals supporting earlier reports on the effectiveness of vaccination against COVID-19 and in role of mass vaccination in combating COVID-19.
Relationship between Serum Thyroid-stimulating Hormone Receptor Autoantibodies and Activity and Severity of Thyroid Eye Disease
Authors: Lee Je Sang , Lee Si Hyung , Kim Bo Yeon , Jang Sun Young
Published: November 2021

Purpose: To study the relationship between the levels of serum thyroid-stimulating hormone (TSH)-receptor autoantibodies (TRAbs) and thyroid eye disease (TED) activity and severity scores.Methods: A cross-sectional study was performed. The medical records of 315 patients diagnosed with TED between March 2014 and December 2019 were reviewed. The clinical activity score (CAS) was used to assess TED activity and a modified NOSPECS score was used for severity grading. The serum TRAb level was measured using two assays: a TSHR binding inhibitory immunoglobulin (TBII) assay and thyroid stimulating immunoglobulin (TSI) bioassay.Results: The TBII and TSI assay results were significantly positively correlated with the CAS (R = 0.113 and 0.211, respectively; p < 0.05), modified NOSPECS score (R = 0.173 and 0.316, respectively; p < 0.05), and proptosis (R = 0.136 and 0.167, respectively; p < 0.05). Both assays demonstrated significant differences in the level of TRAb between patients with and without compressive optic neuropathy or corneal epithelial defects.Conclusions: The levels of TRAbs according to both TBII and TSI assays showed significant correlations with clinical signs of corneal involvement, optic neuropathy, and TED activity and severity.
Clinical Features of Patients with Opacification of Hydrophilic Acrylic Intraocular Lens in Neovascular Glaucoma
Authors: Choi Hun Jin , Han Dong Jin , Shin Joo Youn , Lee Do Hyung , Seo Ji Won , Chung In Kwon , Lee Jong Hyun
Published: November 2021

Purpose: To report the clinical features of patients with opacification of hydrophilic acrylic intraocular lens (IOL) after cataract surgery in neovascular glaucoma.Methods: This retrospective case series included 11 eyes of 10 patients with IOL opacification and neovascular glaucoma (NVG) between January 2006 and December 2010. We included and analyzed cases with opacification of hydrophilic acrylic IOL. An IOL exchange was performed in three cases, and the explanted IOLs were examined grossly and evaluated by light microscopy. Sagittal sections of the optics of the IOLs were evaluated by Von Kossa staining, scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDX).Results: All 11 eyes of 10 patients were implanted with hydrophilic acrylic IOLs. In addition, there were no cases of hydrophobic acrylic IOL opacification. Nine patients of the 10 patients had diabetic retinopathy and one patient had central retinal artery occlusion. The mean period of IOL opacification after IOL implantation was 19.45 ± 8.52 months and the mean period of IOL opacification after the occurrence of NVG was 14.37 ± 8.51 months. The deposits of the explanted IOLs were shown to consist of calcium by von Kossa staining. The explanted IOLs showed fine whitish irregular granular deposits on the entire anterior surface of the optics by SEM and the presence of calcium deposition was confirmed by EDX analysis.Conclusions: Care is required when using hydrophilic acrylic IOLs in patients with risk of neovascular glaucoma, such as those with diabetic retinopathy or central retinal artery occlusion.
Stereoacuity after Successful Occlusion Therapy in Children with Anisometropic Amblyopia
Authors: Lee Sang Wook , Jung Eun Hye
Published: November 2021

Purpose: To compare the stereoacuity between patients with anisometropic amblyopia who were treated and achieved normal visual acuity (VA) and normal children and evaluate the factors associated with stereoacuity.Methods: We retrospectively reviewed the records of 37 pediatric patients with anisometropic amblyopia who recovered to normal VA with glasses and occlusion treatment (amblyopia group) and 34 normal children (control group). The Worth 4-dot test, Lang II test, Titmus test, and TNO test were performed to measure stereoacuity. Clinical characteristics were compared between the two groups, and factors affecting stereoacuity outcomes were also analyzed in the amblyopic group.Results: The mean age at diagnosis of amblyopia was 5.3 ± 1.4 years, and the mean VAs at diagnosis were 0.41 ± 0.24 and 0.06 ± 0.07 in amblyopic and fellow eyes, respectively. The mean duration of occlusion was 19.00 ± 9.44 months, and VA of amblyopic eyes improved to 0.04 ± 0.04 after occlusion treatment. The patient characteristics did not differ significantly between the two groups, except for the final VA of the amblyopic eye. The final mean logarithm of minimal angle of resolution VA of the amblyopic eye in the amblyopia group was significantly worse than that in the control group. The number of patients with normal stereoacuity was significantly lower in the amblyopia group than in the control group on Lang II, Titmus, and TNO tests. Factors associated with poor stereoacuity were severe amblyopia in the Lang II test and poor post-treatment VA of the amblyopic eye in the Titmus test.Conclusions: Stereoacuity was worse in the amblyopia group than in the control group, despite normal visual development. The depth of amblyopia and post-treatment VA were associated with stereoacuity outcomes. Thus, VA improvement should be closely monitored in the amblyopic eye to obtain good stereoacuity.
Recurrent Toxoplasma Retinitis Treated with Long-Term Oral Antibiotics
Authors: Yeom Hosuck , Park Seung Hun , Cho Heeyoon , Shin Yong Un
Published: November 2021

Purpose: The purpose of this case was to report the inhibition of toxoplasma retinitis reactivation with long-term, low-dose antibiotics.Case summary: A 76-year-old woman complained of poor vision and floaters in her right eye. The corrected visual acuity (LogMAR) of the right eye was 0.5, and there was an area of yellow infiltration and dye leakage on the retinal fluorescein angiography images. Toxoplasma IgG were detected in the serum, the patient was diagnosed with toxoplasma retinitis, and the patient was advised oral trimethoprim-sulfamethoxazole, clindamycin, and steroids. Her visual acuity improved and the inflammation resolved. However, she again had decreased visual activity and retinal inflammation in her right eye after 5 months. The inflammation improved with oral steroids, but she was shifted to intravitreal dexamethasone because of the side effects of systemic steroids. Although the inflammation improved initially, there was worsening of inflammation (evidenced by vitreous opacity) after 2 months, which was treated with oral antibiotics. After vitrectomy for the removal of residual vitreous opacity, antibiotics were stopped because of the stable disease course. After discontinuation of the antibiotics, inflammation was noted again, and low-dose trimethoprim-sulfamethoxazole was administered. Low-dose antibiotics were continued for 5 months and the disease remained stable without any retinal inflammation.Conclusions: Long-term, low-dose oral antibiotics may prevent reactivation of recurrent toxoplasma retinitis.
Hume's Rhetorical Strategy: Three Views
Authors: Ooi Daryl
Published: November 2021

In the Fragment on Evil, Hume announces that he ‘shall not employ any rhetoric in a philosophical argument, where reason alone ought to be hearkened to’. To employ the rhetorical strategy, in the context of the Fragment, just is to ‘enumerate all the evils, incident to human life, and display them, with eloquence, in their proper colours’. However, in Part 11 of the Dialogues Concerning Natural Religion, Hume employs precisely this rhetorical strategy. I discuss three interpretations that might account for Hume's decision to employ the strategy in the Dialogues but not the Fragment. The heart of this discussion concerns the relationship between reason and rhetoric. The Dialogues can be understood as part of the education of Pamphilus. Consequently, the three interpretations align with three ways of understanding the roles that reason and rhetoric play in Hume's views on pedagogy and education (or more specifically, Philo's attitude towards the education of Pamphilus).
Immobilized Fe3O4-Polydopamine-Thermomyces lanuginosus Lipase-Catalyzed Acylation of Flavonoid Glycosides and Their Analogs: An Improved Insight Into Enzymic Substrate Recognition
Authors: Wang Zhaoyu , Li Yang , Li Mingyi , Zhang Xiaohui , Ji Qingxia , Zhao Xiaojuan , Bi Yanhong , Luo Si
Published: November 2021

The conversion of flavonoid glycosides and their analogs to their lipophilic ester derivatives was developed by nanobiocatalysts from immobilizing Thermomyces lanuginosus lipase (TLL) on polydopamine-functionalized magnetic Fe3O4 nanoparticles (Fe3O4-PDA-TLL). The behavior investigation revealed that Fe3O4-PDA-TLL exhibits a preference for long chain length fatty acids (i.e., C10 to C14) with higher reaction rates of 12.6–13.9 mM/h. Regarding the substrate specificity, Fe3O4-PDA-TLL showed good substrate spectrum and favorably functionalized the primary OH groups, suggesting that the steric hindrances impeded the secondary or phenolic hydroxyl groups of substrates into the bonding site of the active region of TLL to afford the product.
Resilient Communities: A Novel Workflow
Authors: Carta Silvio , Pintacuda Luigi , Owen Ian Wyn , Turchi Tommaso
Published: November 2021

This study presents a novel workflow to define how resilient communities can be analysed and improved through the optimisation of sustainable design principles through quantitative methods. Our model analyses successful sustainable communities extracting information about daily routines (commuting, working, use of buildings etc.). From these routines, we infer a set of key successful aspects based on location, density and proximity. We then model a resilient community and analyse it using a combination of clustering techniques to find patterns and correlations in the success of existing communities. The proposed workflow is applied to the city of Copenhagen as a case study. The aim of the proposed model is to suggest to designers and city-level policy makers improvements (with manipulation of variables like density, proximity and location of urban typologies) to help them to achieve different levels of sustainable goals as set out by the United Nations Global Challenges including integration inclusiveness and resilience. By using a clustering technique, patterns of proximity have been identified along with density and initial correlations in the observed urban typologies. Some of these correlations were used to illustrate the potential of this novel workflow.