bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Blade Pitch Angle on the Aerodynamic Characteristics of a Straight-bladed Vertical Axis Wind Turbine Based on Experiments and Simulations
Authors: Yang Yanzhao , Guo Zhiping , Song Qing , Zhang Yanfeng , Li Qing’an
Published: June 2018

The blade pitch angle has a significant influence on the aerodynamic characteristics of horizontal axis wind turbines. However, few research results have revealed its impact on the straight-bladed vertical axis wind turbine (Sb-VAWT). In this paper, wind tunnel experiments and CFD simulations were performed at the Sb-VAWT to investigate the effect of different blade pitch angles on the pressure distribution on the blade surface, the torque coefficient, and the power coefficient. In this study, the airfoil type was NACA0021 with two blades. The Sb-VAWT had a rotor radius of 1.0 m with a spanwise length of 1.2 m. The simulations were based on the k-ω Shear Stress Transport (SST) turbulence model and the wind tunnel experiments were carried out using a high-speed multiport pressure device. As a result, it was found that the maximum pressure difference on the blade surface was obtained at the blade pitch angle of β = 6° in the upstream region. However, the maximum pressure coefficient was shown at the blade pitch angle of β = 8° in the downstream region. The torque coefficient acting on a single blade reached its maximum value at the blade pitch angle of β = 6°. As the tip speed ratio increased, the power coefficient became higher and reached the optimum level. Subsequently, further increase of the tip speed ratio only led to a quick reversion of the power coefficient. In addition, the results from CFD simulations had also a good agreement with the results from the wind tunnel experiments. As a result, the blade pitch angle did not have a significant influence on the aerodynamic characteristics of the Sb-VAWT.
Design, Fabrication, and Performance Test of a 100-W Helical-Blade Vertical-Axis Wind Turbine at Low Tip-Speed Ratio
Authors: Han Dowon , Heo Young Gun , Choi Nak Joon , Nam Sang Hyun , Choi Kyoung Ho , Kim Kyung Chun
Published: June 2018

A 100-W helical-blade vertical-axis wind turbine was designed, manufactured, and tested in a wind tunnel. A relatively low tip-speed ratio of 1.1 was targeted for usage in an urban environment at a rated wind speed of 9 m/s and a rotational speed of 170 rpm. The basic dimensions were determined through a momentum-based design method according to the IEC 61400-2 protocol. The power output was estimated by a mathematical model that takes into account the aerodynamic performance of the NACA0018 blade shape. The lift and drag of the blade with respect to the angle of attack during rotation were calculated using 2D computational fluid dynamics (CFD) simulation to take into account stall region. The average power output calculated by the model was 108.34 W, which satisfies the target output of 100 W. The manufactured wind turbine was tested in a large closed-circuit wind tunnel, and the power outputs were measured for given wind speeds. At the design condition, the measured power output was 114.7 W, which is 5.9% higher than that of the mathematical model. This result validates the proposed design method and power estimation by the mathematical model.
Reliability and Maintenance Prioritization Analysis of Combined Cooling, Heating and Power Systems
Authors: Jiang Jinming , Wei Xindong , Gao Weijun , Kuroki Soichiro , Liu Zhonghui
Published: June 2018

A combined cooling, heating, and power (CCHP) system is a complex and repairable system containing a large number of components and series of subsystems. When a failure occurs in one component, it might cause a failure of a subsystem or whole system. Traditional maintenance methods might lead to the waste of maintenance resources and a high cost of maintenance. The reliability and maintenance prioritization analyses can help managers optimize maintenance strategies and reduce the total cost. A reliability importance index is one of the factors in maintenance prioritization analysis. This paper aims at selecting the component reliability importance indices to identify the priority of component maintenance of a CCHP system from the perspective of maintenance cost. Failure cost importance index (FCI) and Potential failure cost importance index (PI) are developed for the maintenance prioritization analysis of a CCHP system. A Markov model based on the state–space method (SSM) is used to analyze the reliability and availability of a CCHP system. A set of actual survey reliability data of CCHP systems is used to support the validity of the reliability importance indices. The results indicate that the FCI and PI might lead to different rankings of maintenance prioritization. The FCI and PI will help managers make a reasonable decision for maintenance on a cost basis.
Taper and Volume Systems Based on Ratio Equations for Pinus pseudostrobus Lindl. in Mexico
Authors: García-Espinoza Guadalupe , Aguirre-Calderón Oscar , Quiñonez-Barraza Gerónimo , Alanís-Rodríguez Eduardo , De Los Santos-Posadas Héctor , García-Magaña J.
Published: June 2018

Studies on functional relationships between relative stem diameter and height to estimate timber yield are useful in the management of commercial forest plantations. With taper analysis data of 42 Pinus pseudostrobus Lindl. trees in the indigenous community of Nuevo San Juan Parangaricutiro , Michoacan, Mexico, six compatible systems for predicting taper (d), merchantable volume (Vm), stem volume (Vs), total tree volume (Vt) and branch volume (Vb) were fitted and evaluated. The compatible taper and merchantable volume equations were based on volume ratio equations. Three Vs equations were tested in each system. In general, the compatible systems presented statistical accuracy in the d, Vm, Vs and Vt components but were less accurate in Vb. Three compatible systems were selected, according to their more efficient goodness-of-fit statistics, and a different total volume equation was incorporated into each system. The compatible systems based on volume ratio equations are simple, reliable tools for estimation of stand timber stocks and product classification of P. pseudostrobus in commercial forest plantations in Mexico.
Fluorinated Phenylalanine Precursor Resistance in Yeast
Authors: Murdoch Ian S. , Powers Samantha L. , Welch Aaron Z.
Published: June 2018

Development of a counter-selection method for phenylalanine auxotrophy could be a useful tool in the repertoire of yeast genetics. Fluorinated and sulfurated precursors of phenylalanine were tested for toxicity in Saccharomyces cerevisiae. One such precursor, 4-fluorophenylpyruvate (FPP), was found to be toxic to several strains from the Saccharomyces and Candida genera. Toxicity was partially dependent on ARO8 and ARO9, and correlated with a strain’s ability to convert FPP into 4-fluorophenylalanine (FPA). Thus, strains with deletions in ARO8 and ARO9, having a mild phenylalanine auxotrophy, could be separated from a culture of wild-type strains using FPP. Tetrad analysis suggests FPP resistance in one strain is due to two genes. Strains resistant to FPA have previously been shown to exhibit increased phenylethanol production. However, FPP resistant isolates did not follow this trend. These results suggest that FPP could effectively be used for counter-selection but not for enhanced phenylethanol production.
The 2017 North Bay and Southern California Fires: A Case Study
Authors: Nauslar Nicholas J. , Abatzoglou John T. , Marsh Patrick T.
Published: June 2018

Two extreme wind-driven wildfire events impacted California in late 2017, leading to 46 fatalities and thousands of structures lost. This study characterizes the meteorological and climatological factors that drove and enabled these wildfire events and quantifies their rarity over the observational record. Both events featured key fire-weather metrics that were unprecedented in the observational record that followed a sequence of climatic conditions that enhanced fine fuel abundance and fuel availability. The North Bay fires of October 2017 occurred coincident with strong downslope winds, with a majority of burned area occurring within the first 12 hours of ignition. By contrast, the southern California fires of December 2017 occurred during the longest Santa Ana wind event on record, resulting in the largest wildfire in California’s modern history. Both fire events occurred following an exceptionally wet winter that was preceded by a severe four-year drought. Fuels were further preconditioned by the warmest summer and autumn on record in northern and southern California, respectively. Finally, delayed onset of autumn precipitation allowed for critically low dead fuel moistures leading up to the wind events. Fire weather conditions were well forecast several days prior to the fire. However, the rarity of fire-weather conditions that occurred near populated regions, along with other societal factors such as limited evacuation protocols and limited wildfire preparedness in communities outside of the traditional wildland urban interface were key contributors to the widespread wildfire impacts.
A Catalog of Photometric Redshift and the Distribution of Broad Galaxy Morphologies
Authors: Paul Nicholas , Virag Nicholas , Shamir Lior
Published: June 2018

We created a catalog of photometric redshift of ∼3,000,000 SDSS galaxies annotated by their broad morphology. The photometric redshift was optimized by testing and comparing several pattern recognition algorithms and variable selection strategies, and was trained and tested on a subset of the galaxies in the catalog that had spectra. The galaxies in the catalog have i magnitude brighter than 18 and Petrosian radius greater than 5.5″. The majority of these objects are not included in previous SDSS photometric redshift catalogs such as the photoz table of SDSS DR12. Analysis of the catalog shows that the number of galaxies in the catalog that are visually spiral increases until redshift of ∼0.085, where it peaks and starts to decrease. It also shows that the number of spiral galaxies compared to elliptical galaxies drops as the redshift increases.
Reactive and Mixing Processes Governing Ammonium and Nitrate Coexistence in a Polluted Coastal Aquifer
Authors: Sbarbati Chiara , Colombani Nicolò , Mastrocicco Micòl , Petitta Marco , Aravena Ramon
Published: June 2018

A comprehensive hydrochemical, stable isotope and microbial analyses characterisation has been performed to evaluate the sources of groundwater, nitrogen pollution and degradation processes occurring in an industrial polluted coastal aquifer in the framework of a complex hydrodynamic system. The coexistence of ammonium and nitrate has been observed in almost all the investigated monitoring wells, reaching maximum values of 100 and 200 mg/L for both species. Chloride and potassium concentration coupled with groundwater stable isotopes data show the influence of local and urban recharge and the occurrence of seawater intrusion in areas near the coastline. δ15N–NH4+ values ranging between −4.9 and +14.9% suggest that different processes such as partial nitrification of ammonium, probably anammox activities and sorption, are occurring at the site. The isotope data for NH4+ also showed the existence of the remnant of an old fertilizer plume in the downgradient area. The nitrate isotope data ranging between +9 and +46% and +6 and +26% for δ15N–NO3− and δ18O–NO3−, respectively, suggest that nitrate content is attenuated by denitrification and probably annamox. The fast groundwater flow field is one of the reasons for the coexistence of NH4+ and NO3− in groundwater, since both compounds can penetrate the reducing zone of the aquifer. The influence of leakage of sewage pipelines on the aquifer cannot be discerned due to the complexities of the nitrogen attenuation processes, also influenced by pumping activities.
Ancient Microbial Activity in Deep Hydraulically Conductive Fracture Zones within the Forsmark Target Area for Geological Nuclear Waste Disposal, Sweden
Authors: Drake Henrik , Ivarsson Magnus , Tillberg Mikael , Whitehouse Martin J. , Kooijman Ellen
Published: June 2018

Recent studies reveal that organisms from all three domains of life—Archaea, Bacteria, and even Eukarya—can thrive under energy-poor, dark, and anoxic conditions at large depths in the fractured crystalline continental crust. There is a need for an increased understanding of the processes and lifeforms in this vast realm, for example, regarding the spatiotemporal extent and variability of the different processes in the crust. Here, we present a study that set out to detect signs of ancient microbial life in the Forsmark area—the target area for deep geological nuclear waste disposal in Sweden. Stable isotope compositions were determined with high spatial resolution analyses within mineral coatings, and mineralized remains of putative microorganisms were studied in several deep water-conducting fracture zones (down to 663 m depth), from which hydrochemical and gas data exist. Large isotopic variabilities of δ13Ccalcite (−36.2 to +20.2‰ V-PDB) and δ34Spyrite (−11.7 to +37.8‰ V-CDT) disclose discrete periods of methanogenesis, and potentially, anaerobic oxidation of methane and related microbial sulfate reduction at several depth intervals. Dominant calcite–water disequilibrium of δ18O and 87Sr/86Sr precludes abundant recent precipitation. Instead, the mineral coatings largely reflect an ancient archive of episodic microbial processes in the fracture system, which, according to our microscale Rb–Sr dating of co-genetic adularia and calcite, date back to the mid-Paleozoic. Potential Quaternary precipitation exists mainly at ~400 m depth in one of the boreholes, where mineral–water compositions corresponded.
Living Dendrolitic Microbial Mats in Hamelin Pool, Shark Bay, Western Australia
Authors: Suosaari Erica P. , Awramik Stanley M. , Reid R. Pamela , Stolz John F. , Grey Kathleen
Published: June 2018

Hamelin Pool, Shark Bay, Western Australia, is home to the largest and most diverse assemblage of living marine stromatolites, with shapes and sizes comparable to ancient structures. A recent field-intensive program revealed seasonally ephemeral occurrences of modern dendrolitic microbial mats forming in intertidal, low energy settings. Dominated by filamentous cyanobacteria, dendrolitic microbial mats are formed when filaments provide a supporting framework as a result of gliding mobility, to build a shrubby morphology. Dendrolites, known throughout the rock record, refer to macroscopic microbialites with mesostuctures composed of unlaminated arborescent structures called shrubs. In these modern examples, thick filaments of Lyngbya aestuarii form the “trunk” of the bush, with finer filaments of Lyngbya fragilis, Phormidium sp. and Schizothrix sp. forming the “branches” These biologically-influenced dendrolitic structures provide insight into the complex interplay of microbial communities and the environment, broadening our understanding of shrub and dendrolite formation throughout the rock record.
The Burden of Dysphagia on Family Caregivers of the Elderly: A Systematic Review
Authors: Namasivayam-MacDonald Ashwini M. , Shune Samantha E.
Published: June 2018

With the rapid increase in the elderly population, there is a simultaneous increased need for care provided by family caregivers. Research in the field of head and neck cancer has indicated that caring for patients with dysphagia can impact a caregiver’s quality of life. Given that many older adults present with dysphagia, one can assume that their caregivers are equally, if not more greatly, affected. The purpose of this systematic review was to examine all relevant literature regarding the caregiver burden in caregivers of community-dwelling older adults with dysphagia. A review of relevant studies published through April 2018 was conducted using search terms related to dysphagia, caregiver burden, and older adults. The search yielded 2331 unique abstracts. Of the 176 abstracts that underwent full review, four were accepted. All reported an increase in caregiver burden due to presence of dysphagia in care recipients. Worsening feeding-related behaviors were associated with burden, and the use of feeding tubes was more frequently associated with “heavy burden”. The presence of dysphagia in community-dwelling older adults is a factor leading to an increased burden among caregivers. Although aspects of dysphagia play a role in the caregiver burden, the specific reasons for the increased burden are unknown. Clinicians should be aware of dysphagia as a source of the burden, and future studies should further define the relationship between dysphagia and the caregiver burden in order to develop comprehensive approaches to care.
Poverty, Weight Status, and Dietary Intake among UK Adolescents
Authors: Noonan Robert
Published: June 2018

The aims of this study were to (1) determine whether an income gradient to overweight and obesity exists in UK adolescents, and (2) examine associations between poverty, weight status, and dietary intake among adolescent girls and boys. Data is from wave six of the UK Millennium Cohort Study. Adolescent height and weight were measured. Body mass index was calculated (kg/m2) and used to classify overweight and obesity. Family income and poverty were determined using equivalised household income. Adjusted logistic and multinomial logistic regression analyses were conducted. Ten thousand seven hundred thirty-six adolescents (5425 boys) had complete data. Adolescents in the lowest income group were at greatest risk of overweight and obesity. Adolescents living in poverty were more likely to be overweight and obese, and reported more frequent consumption of sweetened drinks and fast food and less frequent consumption of fruits and vegetables (p < 0.001). The magnitude of poverty differences in weight status and dietary intake were greatest among girls. This study evidences a strong income gradient to overweight and obesity among UK adolescents. The findings of this study encourage researchers and policy makers to be equally mindful of the social determinants of health when advocating adolescent behavioural dietary interventions.
The Independent Associations between Walk Score® and Neighborhood Socioeconomic Status, Waist Circumference, Waist-To-Hip Ratio and Body Mass Index Among Urban Adults
Authors: McCormack Gavin R. , Blackstaffe Anita , Nettel-Aguirre Alberto , Csizmadi Ilona , Sandalack Beverly , Uribe Francisco Alaniz , Rayes Afrah , Friedenreich Christine , Potestio Melissa L.
Published: June 2018

Background: Environmental and policy factors can influence weight status via facilitating or discouraging physical activity and healthy diet. Despite mixed evidence, some findings suggest that the neighborhood built environment, including “walkability”, is associated with overweight and obesity. Most of these findings have measured body mass index (BMI), yet other weight status measures including waist circumference (WC) and waist-to-hip (W-H) ratio are also predictive of health outcomes, independent of BMI. Our study aim was to estimate the associations between walkability, measured using Walk Score®, and each of WC, W-H ratio, and BMI among urban Canadian adults. Methods: In 2014, n = 851 adults recruited from 12 structurally and socioeconomic diverse neighborhoods (Calgary, Alberta, Canada) provided complete data on a physical activity, health and demographic questionnaire and self-reported anthropometric measures (i.e., height and weight, WC and hip circumference). Anthropometric data were used to estimate WC, W-H ratio, and BMI which were categorized into low and high risk in relation to their potential adverse effect on health. WC and BMI were also combined to provide a proxy measure of both overall and abdominal adiposity. Multivariable logistic regression models estimated odds ratios (OR) and 95% confidence intervals (CI) for associations between each weight status outcome and Walk Score®. Results: A one-unit increase in Walk Score® was associated with lower odds of being high-risk based on WC (OR = 0.99; 95%CI 0.97–0.99). Notably, those residing in socioeconomically disadvantage neighborhoods had significantly higher odds of being high risk based on WC, BMI, and WC-BMI combined compared with advantaged neighborhoods. Conclusions: Interventions that promote healthy weight through the design of neighborhoods that support and enhance the effect of physical activity and diet-related interventions could have a significant population health impact.
Agreement between Future Parents on Infant Feeding Intentions and Its Association with Breastfeeding Duration: Results from the Growing Up in New Zealand Cohort Study
Authors: Marks Emma J. , Grant Cameron C. , De Castro Teresa Gontijo , Bandara Dinusha K. , Wall Clare , Morton Susan M. B.
Published: June 2018

Maternal intentions are believed to have the strongest influence on infant feeding. However, what has rarely been studied, are the associations of maternal and partner intentions, and the influence these factors have on infant feeding. Our objective was to describe breastfeeding intentions of pregnant women and their partners, agreement about these intentions, and whether this agreement is associated with breastfeeding initiation and duration. This study was completed within the Growing Up in New Zealand study. Agreement between mothers and partners on intended initial infant feeding method was fair (κ = 0.21, 95% confidence interval (CI) 0.17–0.25) as was intended breastfeeding duration (κ = 0.25, 95% CI 0.22–0.28). Infants whose parents agreed antenatally on breastfeeding only were more likely to have been breastfed for >6 months, after adjustment for maternal (odds ratio (OR) = 6.3, 95% CI 3.9–10.2) and partner demographics (OR = 5.7, 95% CI 3.6–9.2). Likewise, infants whose parents agreed antenatally to breastfeed for >6 months were more likely to have been breastfed for >6 months, after adjustment for maternal (OR = 4.9, 95% CI 3.9–6.2) and partner demographics (OR = 5.0, 95% CI 4.0–6.3). Interventions that promote breastfeeding to both mothers and partners which enable parents to reach agreement about intended feeding methods have the potential to increase both breastfeeding initiation and duration.
Prevalence of Smoking among Men in Ethiopia and Kenya: A Cross-Sectional Study
Authors: Tang Shangfeng , Bishwajit Ghose , Luba Tegene Regassa , Yaya Sanni
Published: June 2018

While tobacco use remains the largest single cause of premature death in the industrialized countries, low-and-middle income countries are also experiencing a rising burden of the tobacco epidemic and are making various programmatic efforts to tackle the issue. Evidence-based policy making is critical to the long-term success of tobacco intervention programs and is reliant on regular monitoring of the trends and prevalence rates of tobacco use though population-based surveys, which are sparse for countries in eastern Africa. Therefore, in the present study we aimed to (1) estimate the trends in the prevalence of self-reported smoking status; and (2) explore the sociodemographic factors associated with smoking among adult men in Ethiopia and Kenya. Methods: Subjects were 26,919 adult men aged between 15 and 59 years from Ethiopia and Kenya. Nationally representative cross-sectional data on self-reported smoking and relevant sociodemographic indicators were collected from the Demographic and Health Surveys (DHS) conducted in these two countries. Data analysis was performed by descriptive, bivariate, and multivariable methods. Results: In Ethiopia, the prevalence rate of smoking increased from 8.5% in 2005 to 11.7% in 2011. While in Kenya, the rate declined albeit slowly from 22.9% in 2003 to 18.8% in 2008–2009 and 17% in 2014. The prevalence was significantly different in urban and rural areas. In majority of the surveys, prevalence of smoking was highest in the age group of 25–34 years. The prevalence of smoking varied widely across several socioeconomic characteristics. Conclusions: The findings indicate a high rate of smoking among men especially in urban areas, and call for policy actions to address the socioeconomic factors as a part of the policy to strengthen tobacco-control efforts.
Exosomes Derived from Human Induced Pluripotent Stem Cells Ameliorate the Aging of Skin Fibroblasts
Authors: Oh Myeongsik , Lee Jinhee , Kim Yu Jin , Rhee Won Jong , Park Ju Hyun
Published: June 2018

Stem cells and their paracrine factors have emerged as a resource for regenerative medicine. Many studies have shown the beneficial effects of paracrine factors secreted from adult stem cells, such as exosomes, on skin aging. However, to date, few reports have demonstrated the use of exosomes derived from human pluripotent stem cells for the treatment of skin aging. In this study, we collected exosomes from the conditioned medium of human induced pluripotent stem cells (iPSCs) and investigated the effect on aged human dermal fibroblasts (HDFs). Cell proliferation and viability were determined by an MTT assay and cell migration capacity was shown by a scratch wound assay and a transwell migration assay. To induce photoaging and natural senescence, HDFs were irradiated by UVB (315 nm) and subcultured for over 30 passages, respectively. The expression level of certain mRNAs was evaluated by quantitative real-time PCR (qPCR). Senescence-associated-β-galactosidase (SA-β-Gal) activity was assessed as a marker of natural senescence. As a result, we found that exosomes derived from human iPSCs (iPSCs-Exo) stimulated the proliferation and migration of HDFs under normal conditions. Pretreatment with iPSCs-Exo inhibited the damages of HDFs and overexpression of matrix-degrading enzymes (MMP-1/3) caused by UVB irradiation. The iPSCs-Exo also increased the expression level of collagen type I in the photo-aged HDFs. In addition, we demonstrated that iPSCs-Exo significantly reduced the expression level of SA-β-Gal and MMP-1/3 and restored the collagen type I expression in senescent HDFs. Taken together, it is anticipated that these results suggest a therapeutic potential of iPSCs-Exo for the treatment of skin aging.
Systematic Analysis of Long Non-Coding RNAs and mRNAs in the Ovaries of Duroc Pigs During Different Follicular Stages Using RNA Sequencing
Authors: Liu Yi , Li Mengxun , Bo Xinwen , Li Tao , Ma Lipeng , Zhai Tenjiao , Huang Tao
Published: June 2018

The dynamic process involving the selection and maturation of follicles is regulated and controlled by a highly synchronized and exquisitely timed cascade of gene expression. Studies have shown that long non-coding RNA (lncRNA) is essential for the normal maintenance of animal reproductive function and has an important regulatory function in ovarian development and hormone secretion. In this study, a total of 2076 lncRNAs (1362 known lncRNAs and 714 new lncRNAs) and 25,491 mRNAs were identified in libraries constructed from Duroc ovaries on days 0, 2 and 4 of follicle development. lncRNAs were shorter, had fewer exons, exhibited a shorter ORF (Open Reading Frame) length and lower expression levels, and were less conserved than mRNAs. Furthermore, 1694 transcripts (140 lncRNAs and 1554 mRNAs) were found to be differentially expressed in pairwise comparisons. A total of 6945 co-localized mRNAs were detected in cis in 2076 lncRNAs. The most enriched GO (Gene Ontology) terms were related to developmental processes. KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway analysis revealed that the differentially expressed lncRNAs targeted mRNAs, and the differentially expressed mRNAs were related to the TGF-β signaling pathway, the PI3K-Akt signaling pathway, the Retinol metabolic pathway and the Wnt signaling pathway. This study deepened our understanding of the genetic basis and molecular mechanisms of follicular development in pigs.
Phoenixin—A Pleiotropic Gut-Brain Peptide
Authors: Schalla Martha A. , Stengel Andreas
Published: June 2018

Phoenixin is a recently discovered brain peptide initially thought to be restricted to reproductive functions. The subsequent identification of phoenixin’s expression in peripheral tissues was accompanied by the description of several other actions of this hormone, such as effects on behavior, sensory perception, memory retention, the cardiovascular system as well as food intake, pointing towards a pleiotropic role of this peptide. The present review will discuss the present knowledge on phoenixin and the signaling involved as well as highlight gaps in knowledge to stimulate further research.
Caveolin-1 Scaffolding Domain Peptides Alleviate Liver Fibrosis by Inhibiting TGF-β1/Smad Signaling in Mice
Authors: Lu Jing , Zhang Jie , Wang Yan , Sun Quan
Published: June 2018

Liver fibrosis is the common pathological process characterized by activation of hepatic stellate cells (HSCs) and overproduction of extracellular matrix (ECM). Caveolin-1 (Cav1), the principal component of caveolae, is regarded as an important inhibitor of multiple signaling molecules including transforming growth factor β1(TGF-β1) signaling. To evaluate the role of Cav1 in liver fibrosis, Cav1 deficient (Cav1−/−) and wild type (WT) mice were subjected to liver fibrosis induced by carbon tetrachloride (CCl4). Results indicated no significant difference between Cav1−/− and WT mice in inflammation or collagen content before CCl4 treatment. After CCl4 administration, Cav1−/− mice showed enhanced TGF-β1 signaling, as reflected by a significantly greater amount of phosphorylation of Smad2 and collagen deposition in livers over WT animals. Qualitative and quantitative analysis indicated that inflammatory injury to the liver was markedly aggravated, accompanied by increased degeneration and necrosis of hepatocytes, higher alanine aminotransferase (ALT)/aspartate aminotransferase (AST), TGF-α and IL-1β levels in Cav1−/− animals. The mRNA and protein levels of α-smooth muscle actin (α-SMA), Collagen α1(I), and Collagen α1(III) were further enhanced in Cav1−/− animals. We also observed a significant decrease in collagen content in Cav1−/− and WT animals administrated with Cav1 scaffolding domain peptides (CSD). In vitro study indicated that phosphorylation of Smad2 was inhibited after CSD treatment, accompanied by decreased protein levels of α-SMA, Collagen α1(I), and Collagen α1(III) in HSCs. We conclude that Cav1 is an important inhibitor of TGF-β1/Smad signaling in HSCs activation and collagen production, which might make it a promising target for therapy of liver fibrosis.
Best Practices Kits for the ICT Governance Process within the Secretariat of State-Owned Companies of Brazil and Regarding these Public Companies
Authors: Canedo Edna Dias , Da Costa Ruyther Parente , De Sousa Junior Rafael Timóteo , Amvame Nze Georges Daniel
Published: June 2018

This article introduces an Information and Communication Technology Governance Kit to be used by the Brazilian Secretariat of Coordination and Governance of State Enterprises (in Portuguese, Secretaria de Coordenação e Governança das Empresas Estatais—SEST) in regards to its governed companies. The proposed kit is an instrument of targeting, which presents a set of best practices and conditioning aimed at the development and implementation of improvements in the management of ICT resources by Brazilian state-owned companies that are controlled by SEST. The proposed kit comprises three situation scenarios and four maturity levels. For each proposed process, the artifacts and templates are presented for the controlled companies to implement their respective processes so that these companies guide the improvements in their ICT governance maturity level. Considering that SEST is the principal entity in this governance structure, the main contribution of the proposed kits is to facilitate, guide and improve the maturity level of all Brazilian state-owned enterprises.
Pythagorean Fuzzy Muirhead Mean Operators and Their Application in Multiple-Criteria Group Decision-Making
Authors: Zhu Jianghong , Li Yanlai
Published: June 2018

As a generalization of the intuitionistic fuzzy set (IFS), a Pythagorean fuzzy set has more flexibility than IFS in expressing uncertainty and fuzziness in the process of multiple criteria group decision-making (MCGDM). Meanwhile, the prominent advantage of the Muirhead mean (MM) operator is that it can reflect the relationships among the various input arguments through changing a parameter vector. Motivated by these primary characters, in this study, we introduced the MM operator into the Pythagorean fuzzy context to expand its applied fields. To do so, we presented the Pythagorean fuzzy MM (PFMM) operators and Pythagorean fuzzy dual MM (PFDMM) operator to fuse the Pythagorean fuzzy information. Then, we investigated their some properties and gave some special cases related to the parameter vector. In addition, based on the developed operators, two MCGDM methods under the Pythagorean fuzzy environment are proposed. An example is given to verify the validity and feasibility of our proposed methods, and a comparative analysis is provided to show their advantages.
An Extended-Tag-Induced Matrix Factorization Technique for Recommender Systems
Authors: Han Huirui , Huang Mengxing , Zhang Yu , Bhatti Uzair Aslam
Published: June 2018

Social tag information has been used by recommender systems to handle the problem of data sparsity. Recently, the relationships between users/items and tags are considered by most tag-induced recommendation methods. However, sparse tag information is challenging to most existing methods. In this paper, we propose an Extended-Tag-Induced Matrix Factorization technique for recommender systems, which exploits correlations among tags derived by co-occurrence of tags to improve the performance of recommender systems, even in the case of sparse tag information. The proposed method integrates coupled similarity between tags, which is calculated by the co-occurrences of tags in the same items, to extend each item’s tags. Finally, item similarity based on extended tags is utilized as an item relationship regularization term to constrain the process of matrix factorization. MovieLens dataset and Book-Crossing dataset are adopted to evaluate the performance of the proposed algorithm. The results of experiments show that the proposed method can alleviate the impact of tag sparsity and improve the performance of recommender systems.
Real-Time and Embedded Detection of Hand Gestures with an IMU-Based Glove
Authors: Mummadi Chaithanya , Leo Frederic , Verma Keshav , Kasireddy Shivaji , Scholl Philipp , Kempfle Jochen , Laerhoven Kristof
Published: June 2018

This article focuses on the use of data gloves for human-computer interaction concepts, where external sensors cannot always fully observe the user’s hand. A good concept hereby allows to intuitively switch the interaction context on demand by using different hand gestures. The recognition of various, possibly complex hand gestures, however, introduces unintentional overhead to the system. Consequently, we present a data glove prototype comprising a glove-embedded gesture classifier utilizing data from Inertial Measurement Units (IMUs) in the fingertips. In an extensive set of experiments with 57 participants, our system was tested with 22 hand gestures, all taken from the French Sign Language (LSF) alphabet. Results show that our system is capable of detecting the LSF alphabet with a mean accuracy score of 92% and an F1 score of 91%, using complementary filter with a gyroscope-to-accelerometer ratio of 93%. Our approach has also been compared to the local fusion algorithm on an IMU motion sensor, showing faster settling times and less delays after gesture changes. Real-time performance of the recognition is shown to occur within 63 milliseconds, allowing fluent use of the gestures via Bluetooth-connected systems.
Use of Recycled Pulped Chromated Copper Arsenate-Treated Wood Fibre in Polymer Composites
Authors: Peerbooms Wouter , Pickering Kim L.
Published: June 2018

The goal of this study was to investigate if it is possible to recycle chromated copper arsenate (CCA)-treated wood for use in wood polymer composites. This was done by soda pulping wood chips of CCA-treated lumber in a laboratory-scale digester. Composites of 10–30 weight percentage of filler in polypropylene were produced with and without the addition of maleic anhydride grafted polypropylene (MAPP) as a coupling agent. These composites were produced using extrusion compounding and injection moulding. The mechanical properties were determined using tensile testing; the properties examined in this study are the ultimate tensile strength, Young’s modulus and strain at break. The effect of the CCA-treated filler on the dimensional stability was investigated by comparing the moisture absorption with virgin wood-filled composites. It was found that ultimate tensile strength improves with increasing filler percentage for the compositions with MAPP. The Young’s modulus increases with increasing filler percentage for all compositions, and failure strain decreases with increasing filler percentage for all compositions. Moisture absorption studies show that the moisture absorption decreases when MAPP is added to the composite, and a slight decrease in moisture uptake is observed for the CCA-treated wood composites with respect to the virgin wood composites.
The Epidemic of Obesity and Poor Physical Activity Participation: Will We Ever See a Change?
Authors: West Sarah L. , Caterini Jessica , Banks Laura , Wells Greg D.
Published: June 2018

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Software and DVFS Tuning for Performance and Energy-Efficiency on Intel KNL Processors
Authors: Calore Enrico , Gabbana Alessandro , Schifano Sebastiano Fabio , Tripiccione Raffaele
Published: June 2018

Energy consumption of processors and memories is quickly becoming a limiting factor in the deployment of large computing systems. For this reason, it is important to understand the energy performance of these processors and to study strategies allowing their use in the most efficient way. In this work, we focus on the computing and energy performance of the Knights Landing Xeon Phi, the latest Intel many-core architecture processor for HPC applications. We consider the 64-core Xeon Phi 7230 and profile its performance and energy efficiency using both its on-chip MCDRAM and the off-chip DDR4 memory as the main storage for application data. As a benchmark application, we use a lattice Boltzmann code heavily optimized for this architecture and implemented using several different arrangements of the application data in memory (data-layouts, in short). We also assess the dependence of energy consumption on data-layouts, memory configurations (DDR4 or MCDRAM) and the number of threads per core. We finally consider possible trade-offs between computing performance and energy efficiency, tuning the clock frequency of the processor using the Dynamic Voltage and Frequency Scaling (DVFS) technique.
Using (VA)RTM with a Rigid Mould to Produce Fibre Metal Laminates with Proven Impact Strength
Authors: Hergan Patrick , Li Yanxiao , Zaloznik Lasse , Kaynak Baris , Arbeiter Florian , Fauster Ewald , Schledjewski Ralf
Published: June 2018

The production of fibre metal laminates (FMLs) is a time consuming and expensive procedure. This paper shows the application of the vacuum assisted resin transfer moulding ((VA)RTM) technique using an injection unit and a rigid mould for the production of FMLs. This processing technique, in combination with a corona discharge activation of the aluminium surface, can lead to enormous reductions to the cycle time. To prove the quality of the produced FML, impact tests were carried out. The influence of the impact energy on the specimen is observed using a deformation scan and ultrasound C-Scan. Furthermore, the peak forces and permanent deflections of the tested specimen were analysed.
Ballast Water Management in the Black Sea’s Ports
Authors: Rata Vasile , Gasparotti Carmen , Rusu Liliana
Published: June 2018

The objective of this work is to develop a case study in order to improve the ballast water management in the Black Sea’s ports. From this perspective, the present paper provides an extensive explanation about the main issues related to the control of marine non-indigenous species introduction through ballast water discharged by ships during their operations in the ports. Thereafter, it quantifies the amount of the ballast water discharged in the major ports of the Black Sea and the amount of the invading species that could reach these ports. Although, globally speaking, the problem of ballast water management is a reality, only three of the six neighboring countries in the Black Sea basin have signed, in 2004, the ratification of the International Convention on Management of Ships’ Ballast Water and Sediments. This is also known as the Water Ballast Management Convention, and it provides regulations concerning ballast water management generated by the shipping activities through a common set of rules.
Frequency Analysis of Storm-Surge-Induced Flooding for the Huangpu River in Shanghai, China
Authors: Ke Qian , Jonkman Sebastiaan N. , Van Gelder Pieter H. A. J. M. , Bricker Jeremy D.
Published: June 2018

Shanghai, as a coastal city, is vulnerable to various types of flooding. The floodwalls along the Huangpu River provide protection against typhoon-induced flooding. However, there is limited insight into the actual safety level of the flood defences in Shanghai, and recent failures have highlighted their vulnerability. Therefore, the aims of this paper are to derive a series of new flood frequency curves for the Huangpu River, and to evaluate the level of protection of the floodwall system. This paper analysed over 100 years (1912–2013) of annual maximum water levels for three stations at near-sea, mid-stream and inland locations along the Huangpu River. Best-fit curves were determined for a number of selected probability distributions using statistical performance indicators. As a result, new flood frequency curves of the water levels for different storm surge return periods were produced. The results showed that generalised extreme value (GEV) was identified as the most suitable probability distribution for the datasets. Analysis showed that the current design water levels correspond to exceedance probabilities of 1/500 per year at the near-sea and mid-stream stations, and no more than 1/50 per year at the inland station of the Huangpu River, whereas the intended safety standard is 1/1000 per year. A comparison of the findings with a dataset of the crest heights of the floodwalls showed that the current protection level of the floodwalls along the Huangpu River is expected to be around 1/50 per year in terms of overtopping for the lowest sections. The results of this study can be utilized to provide future recommendations for flood risk management in Shanghai.
Best Fitting Fat Tail Distribution for the Volatilities of Energy Futures: Gev, Gat and Stable Distributions in GARCH and APARCH Models
Authors: Gunay Samet , Khaki Audil
Published: June 2018

Precise modeling and forecasting of the volatility of energy futures is vital to structuring trading strategies in spot markets for risk managers. Capturing conditional distribution, fat tails and price spikes properly is crucial to the correct measurement of risk. This paper is an attempt to model volatility of energy futures under different distributions. In empirical analysis, we estimate the volatility of Natural Gas Futures, Brent Oil Futures and Heating Oil Futures through GARCH and APARCH models under gev, gat and alpha-stable distributions. We also applied various VaR analyses, Gaussian, Historical and Modified (Cornish-Fisher) VaR, for each variable. Results suggest that the APARCH model largely outperforms the GARCH model, and gat distribution performs better in modeling fat tails in returns. Our results also indicate that the correct volatility level, in gat distribution, is higher than those suggested under normal distribution with rates of 56%, 45% and 67% for Natural Gas Futures, Brent Oil Futures and Heating Oil Futures, respectively. Implemented VaR analyses also support this conclusion. Additionally, VaR test results demonstrate that energy futures display riskier behavior than S&P 500 returns. Our findings suggest that for optimum risk management and trading strategies, risk managers should consider alternative distributions in their models. According to our results, prices in energy markets are wilder than the perception of normal distribution. In this regard, regulators and policy makers should enhance transparency and competitiveness in the energy markets to protect consumers.
Typological Differences in Morphological Patterns, Gender Features, and Thematic Structure in the L2 Acquisition of Ashaninka Spanish
Authors: Sánchez Liliana , Mayer Elisabeth
Published: June 2018

It has been widely argued that morphological competence, particularly functional morphology, represents the bottleneck of second language acquisition (Jensen et al. 2017; Lardiere 1998, 2005; Slabakova 2008, 2009, 2013). In this study, we explore three challenging aspects of the morphology of Spanish among advanced L1 Ashaninka—L2 Spanish speakers: (i) the acquisition of proclitics and enclitics with inflected verbs; (ii) the distribution of accusative clitics according to the thematic role of the direct object in anaphoric and doubling structures; and (iii) the distribution of clitic forms and their association with gender features. Our results show evidence of the L2 acquisition of clitic structures in L2 Spanish speakers, and no difference between native and L2 speakers regarding sensitivity to thematic roles. However, there are statistically significant differences between groups in the distribution of the gender specification of the clitic antecedents or doubled determiner phrases (DPs). We take these results as evidence in support of the view that morphological patterns can be acquired (proclitics vs. suffixes) as well as preferences for mapping thematic roles onto clitics, but subtle differences in the continuum of preferences for mapping gender features are more difficult to acquire.
The Particle Shape of WC Governing the Fracture Mechanism of Particle Reinforced Iron Matrix Composites
Authors: Li Zulai , Wang Pengfei , Shan Quan , Jiang Yehua , Wei He , Tan Jun
Published: June 2018

In this work, tungsten carbide particles (WCp, spherical and irregular particles)-reinforced iron matrix composites were manufactured utilizing a liquid sintering technique. The mechanical properties and the fracture mechanism of WCp/iron matrix composites were investigated theoretically and experimentally. The crack schematic diagram and fracture simulation diagram of WCp/iron matrix composites were summarized, indicating that the micro-crack was initiated both from the interface for spherical and irregular WCp/iron matrix composites. However, irregular WCp had a tendency to form spherical WCp. The micro-cracks then expanded to a wide macro-crack at the interface, leading to a final failure of the composites. In comparison with the spherical WCp, the irregular WCp were prone to break due to the stress concentration resulting in being prone to generating brittle cracking. The study on the fracture mechanisms of WCp/iron matrix composites might provide a theoretical guidance for the design and engineering application of particle reinforced composites.
Cononsolvency Transition of Polymer Brushes: A Combined Experimental and Theoretical Study
Authors: Yong Huaisong , Rauch Sebastian , Eichhorn Klaus-Jochen , Uhlmann Petra , Fery Andreas , Sommer Jens-Uwe
Published: June 2018

In this study, the cononsolvency transition of poly(N-isopropylacrylamide) (PNiPAAm) brushes in aqueous ethanol mixtures was studied by using Vis-spectroscopic ellipsometry (SE) discussed in conjunction with the adsorption-attraction model. We proved that the cononsolvency transition of PNiPAAm brushes showed features of a volume phase transition, such as a sharp collapse, reaching a maximum decrease in thickness for a very narrow ethanol volume composition range of 15% to 17%. These observations are in agreement with the recently published preferential adsorption model of the cononsolvency effect.