bluuebunny/crossref_metadata_2025 huggingface dataset:
RESPIRATORY SCLEROMA WITH CHRONIC STENOSIS OF THE TRACHE OF THE III CENTURY IN A SENIOR PATIENT
Authors: Plaksyvy O. , Kalutsky І. , Mazur O. , Manchulenko М.
Published: October 2022

Scleroma is an endemic disease, spread mainly in Western Ukraine, Western Belarus and adjacent areas. Scleroma refers to chronic diseases that mainly aﬀ ect the mucous membrane of the upper respiratory tract. This clinical case attracted attention due to the rare diagnosis of the disease, the patient’s age (88 years), the most di ﬃ cult localization of the process in terms of clinical course, pronounced concentric funnel- shaped narrowing of the trachea to 5-6 mm lumen for 4-5 cm long trachea with severe chronic stenosis.
Features of the flexor retinaculum and its individual variation in carpal tunnel syndrome predisposition - a systematic review
Authors: Krupa Robert , Suchanecka Małgorzata , Mrożek Andrzej , Siwek Katarzyna
Published: October 2022

The flexor retinaculum is a structure located in the wrist, which spreads between the bones forming the carpal tunnel. Its task is to maintain the relative stabilization and protection of incorporated structures. It is also an attachment for the thenar muscles, causing biomechanical interactions in the wrist. Pathologies occurring in the carpal tunnel structures often cause pressure increase, leading to compression of the median nerve, causing carpal tunnel syndrome (CTS). This work aims to review literature knowledge and compile research outcomes in the PubMED and Google scholar databases.

The results indicate the variability in size and aspects of flexor retinaculum due to gender, and the relationship between gender and the incidence of CTS. The data also show the flexor retinaculum’s molecular variability and environmental factors’ potential impact on these changes. This article demonstrates how anatomical conditions and physical features influence CTS development.
Study of Shock Wave Development in Cold Flow of Gas Circuit Breaker for Improving Capacitive Current Switching
Authors: Gu Wei , Tian Ruyuan , Guo Zide , Feng Dingyu
Published: October 2022

Capacitive current switching performance of SF6 circuit breaker is determined by combined action of gas flow and electric field in interruption chamber. Computational fluid dynamics method is used to study the development of shock waves inside a SF6 circuit breaker under the condition of capacitive current switching. It was found that a shock wave exists and travels with the pin contact during the contact opening. Existence of shock waves reduces the local gas density around contact head, while the contact head is also stressed by high electric field at the same time. If the region of low gas density coincides with the region with high electric strength, local dielectric performance will be significantly reduced. Using E/ρ as the dielectric performance index, when the local value of E/ρ exceeds the gas breakdown criterion, it will result in restrike to the capacitive current switching. The causes of high E/ρ are studied by analyzing the shock waves during the sequential periods of contact travel. Since the gap between the pin contact and nozzle throat strongly affects the strength of shock wave, the behavior of gap is studied with the calculation of E/ρ to find its influence on capacitive current switching.
The Digital Transformation of Legal Industry: Management Challenges and Technological Opportunities
Authors: Mania Karolina
Published: October 2022

The impact of technology on individual economic sectors has also reached the service industry. This article offers a discussion on the influence of information technologies (IT) and changes taking place as a result of the legal services market digital transformation.

Thanks to the results of the qualitative study (questionnaire survey a technique of data collection) involving 451 respondents (attorneys and legal counsels) in Poland, it was possible to analyse t lawyers’ attitudes towards particular IT tools and systems as well as the changes taking place in the field of legal services, the business models applied thus far and innovation factors.

The gained knowledge shows the current level of technology use in the daily work of lawyers and their attitude towards changes induced by omnipresent digitalization. The results offer vast opportunities for using the knowledge so acquired at academic and business levels, especially by providers of IT solutions for legal professionals.
Different Impact of the Recession on the Labour Market: Less Work Without Increasing Unemployment in Slovakia
Authors: Morvay Karol , Hudcovský Martin
Published: October 2022

The paper examines why the pandemic recession hit the labour market in Slovakia differently from previous recessions. Traditionally, the unemployment rose sharply during previous economic recessions. Therefore, it seemed like a novelty when the unemployment rate rose only insignificantly in a pandemic recession. We find that both the demand and supply side of the labour market played their role in it. Labour demand has been affected differently compared to the past: Instead of the usual sharp increase in unemployment during a recession, the rate of utilization of workers’ time capacities fell, with expected impacts also on income differentiation. This is in line with the way more advanced European economies have responded to recessions before. In addition, a new element was also present on the labour force supply side. In previous recessions, the labour force supply had been rising; in the recent pandemic recession, it fell for the first time.
Assesment of heavy metals concentration in initial soils of post-mining landscapes in Kryvyi Rih District (Ukraine)
Authors: Savosko Vasyl M. , Bielyk Yuliia V. , Lykholat Yuriy V. , Heilmeier Hermann
Published: October 2022

Assessment of heavy metals content in the initial soils of the post-mining landscapes plays an important role in pollution control, ecological protection, and safe-guarding human health. In this study, the site-specific pedogeochemical background contents of several metals in soils in Kryvyi Rih Iron Ore Mining & Metallurgical District (central part of Ukraine) were determined. The metal concentrations in the soils of Petrovsky waste rock dump were also quantified and were also assessed using indices of pollution. The field sampling was carried out at a depth of 0-10 cm in five plots in dump area and in one plot in control site. The 43 soil samples were collected. The results showed that local background concentrations of heavy metals in soils of studied area decreased in the following order (mg×kg−1): Fe (42 510) > Mn (761.7) > Cr (94.48) > Zn (90.51) > > As (31.85) > Cu (28.10) > Pb (18.73) > Co (16.21) > Sn (4.64) > Mo (0.28) > Cd (0.16). In the initial soils of devastated lands at Petrovsky waste rock dumps the predominance of increased Cd, Co, Fe, Mm, Mo and Sn content and the predominance of decreased As, Cr and Pb content were observed. Based on the mean values of the individual indices of pollution (Pollution index, Geoaccumulation index, Enrichment factor, Contamination factor) can be assumed that in these soils As, Cd, Fe, Mo, Pb and Sn are mostly coming from industrial activities. Co, Cr, Cu, Mn and Zn are mostly related to their natural occurrence in devastated lands. The values of integrated indices of pollution (Nemerow pollution index, Pollution load index, Degree of contaminated, Modified degree of contamination) indicated that the initial soils of post-mining landscapes can be evaluated as no polluted – and extremely heavy polluted.
Farmers’ Preference and Willingness to Pay for Climate-Smart Rice Varieties in Uzo-Uwani Local Government Area of Enugu State, Nigeria
Authors: Onugo Theresa Nnenna , Onyeneke Robert Ugochukwu
Published: October 2022

This paper examined farmers’ preference and willingness to pay (WTP) for climate-smart rice varieties in Uzo-Uwani Local Government Area of Enugu State, Nigeria. A total of 80 respondents were purposely selected from 5 major rice growing communities in the study area. Questionnaire was the main tool for data collection. Also, data on climate elements (such as temperature and rainfall volume) for a period of 35 years (1986–2020) were obtained from the Nigerian Meteorological Agency (NIMET). Multinomial logit model, ordinary least square (OLS) regression model, descriptive statistics and trend analysis were employed for data analysis. The results show that FARO 44 was preferred by 95% of the farmers for grain size, 100% of farmers preferred it for days to maturity, 76.2% preferred it for strength of grain to withstand breakage during processing, 98.75% preferred it for potential yield (tons) and plant height (cm) and 87.5% preferred it for its ecological adaptation. Farmers’ preference and willingness to pay for climate-smart rice varieties were influenced by attributes of these varieties and knowledge of such technologies, primary occupation, farm size, extension visits and access to media information and farm size. This study recommends that government should provide extension agents with the adequate resources to enable them carry out their duties more effectively.
Design and Construction of an Automatic Voltage Regulator for a Synchronous Alternator
Authors: Emezirinwune M.U.
Published: October 2022

The Automatic Voltage Regulator (AVR) is necessary to keep the terminal voltage of a loaded alternator constant. It is widely used to increase the regulation and stability of synchronous alternators especially in bulk power plants where efficiency and stability is of paramount importance. The AVR is a feedback controller that varies the excitation of the alternator to support a constant output voltage by increasing or decreasing the excitation level of the alternator as the load varies. In this research, the transfer functions of the various stages of the AVR are decided for the purpose of the design of the Voltage Regulator. The performance of the AVR is decided by the basic no load and load test on the alternator. The results show that there was tremendous improvement in the terminal voltage of the alternator with the AVR and a significant drop in the terminal voltage of the alternator without the AVR.
Efficient Security Systems Solutions for Smart Homes
Authors: Pica A.Ș. , Bănescu Isabela Elena
Published: October 2022

In this article we aim to make an analysis of the evolution of security systems for smart homes and to present some effective solutions. Manufacturers are not developing smart devices from scratch, but are using existing solutions launched by large IT companies to help build smart home networks. The sensors are integrated in different places in homes, offices, equipment, sometimes even clothes, to detect and monitor the location, actions, necessary signs, room temperature and humidity levels of users properties. However, ensuring confidentiality and effective security is a major challenge for smart homes. The increased risk of data security and information leakage makes smart home security an important challenge that needs to be carefully considered.
High Accuracy Testing of MPPT Proteus Model Performance for Photovoltaic System
Authors: Affari Belhadj Chekal , Kahoul Nabil , Chenni Rachid , Neçaibia Ammar , Younes Mouhammed , Kherici Zoubida
Published: October 2022

This study examines the performance of the MPPT Proteus model. The high performance of this model was proposed for a photovoltaic system and tested using the most commonly known MPPT techniques. The proposed Proteus model is a simulator of a maximum power point tracking system for a photovoltaic panel connected to the DC-DC converter with digital control. The Proteus software performs simulation and implementation of the photovoltaic panel model based on a one-diode model and a two-diode model with high accuracy. Both photovoltaic panel models were validated by experimental measurements. Simulation results for tracking voltage, tracking current and tracking power show that this model performs satisfactorily. The theoretical evaluation confirms the high performance of the MPPT Proteus model, which offers a high degree of control and planning.
Romania’s Social Changes During the Sars Cov 2 Pandemic, as Effect of the Digitalisation Process
Authors: Soare Claudia Mariana , Pica A.Ș.
Published: October 2022

The article’s main purpose is to analyse the effects of the “forced “digitalization process on the changes of the social attitudes appeared when the Covid 19 pandemic started. We will also outline efficient solutions to adapt to the new surrounding reality. The study aims to present a complete and objective analysis on the way the pandemic imposed not only behavioural and social changes, but also different visions at society level, about the imminent need for the digitalization process.
Infocolinda – An Inovative Way of Musical and Literary Analysis for Carols
Authors: Lavinia-Maria Chiş
Published: October 2022

This article presents a desktop application which purpose is to help ethnomusicologists, music specialists and researchers in managing better the possible results of a field folklore investigation. Because a field investigation in ethnomusicology, ethnology and ethnography domain generates a huge video or audio material, it can be extremely difficult and time spending for specialists to handle with it, to extract all the information needed, to organize and to make a specialized analysis for a report or for a specific study in a traditional manner. At the same time, computer programming and database practice can have a major impact on musical and literary analysis of folklore songs, especially when they are put together within an application. The purpose of this article is to suggest and to describe such a computer application.
Determination of Distance in Fiber Optical Communications Networks
Authors: Stănescu C. , Preduşcă G. , Circiumarescu D. , Dumitrache C.
Published: October 2022

The design of an optical system sets up the knowledge of the limitations dictated by the losses and dispersion in the optical fiber (in direct connection with the wavelength used) for a point-to-point connection. Except for short links used in local area networks, attenuation losses play a significant role in system design. The paper aims to analyse a fiber connection in terms of the best communication distance using Octave and Packet Tracer.
Accounting for the recognition of intangible assets and the results of their valuation and revaluation
Authors: ALBOROV Rolan A. , KOZMENKOVA Svetlana V. , MOSUNOVA Ekaterina L.
Published: October 2022

Subject. This article deals with the issues of valuation and accounting of intangible assets.
Objectives. The article aims to disclose the organizational, methodological, and technical aspects of accounting for intangible assets and develop methodological recommendations for accounting for the results of revaluation of the value of intangible assets in accounts of organizations.
Methods. For the study, we used analysis and synthesis, modeling, abstraction, etc.
Results. The article reveals the organizational and methodological aspects of accounting for the recognition of intangible assets, the results of their valuation and revaluation, and it substantiates the methods and technical aspects of reflecting operations based on the results of revaluation of intangible assets in accounts.
Conclusions and Relevance. To ensure the objectivity and reliability of intangible asset accounting data, federal and international accounting standards should be followed, and intangible assets should be clearly classified for accounting purposes into homogeneous groups. The results of the article can be applied both in the theory and practice of financial accounting.
Prospects for accounting for intangible assets: Interpretation of the economic essence and conditions of recognition
Authors: DRUZHILOVSKAYA Tat'yana Yu.
Published: October 2022

Subject. This article discusses the issues related to the regulation of the interpretation and recognition of intangible assets.
Objectives. The article aims to identify the prospects for solving the problematic aspects of the interpretation of the economic essence of intangible assets and the criteria for their recognition in accounting and reporting.
Methods. For the study, I used a critical analysis, synthesis, comparison, observation, and the analogy approach.
Results. The article presents the results of a study of new approaches to the interpretation of the economic essence and recognition of intangible assets in the FSBU Projects – Intangible Assets, developed by the Ministry of Finance of the Russian Federation and the National Non-Governmental Accounting Regulator "Accounting Methodological Center" (NRBU BMTs Fund).
Conclusions and Relevance. Each of the Projects under consideration has both advantages and disadvantages with regard to the interpretation of the economic essence and the regulation of criteria for the recognition of intangible assets. Both the Projects are a step forward with regard to the regulation of these issues compared to PBU 14/2007. The results obtained have both practical and theoretical areas of application in the field of financial accounting.
Natural Regeneration of Parkia biglobosa (Néré): Status and variation along the South-North climatic gradient in Mali
Authors: Kelly Bokary Allaye , Kouyaté Amdou Malé , Dembélé Sidiki Gabriel
Published: October 2022

Parkia biglobosa offers food, medicine and income to rural populations. A study, was undertaken in three agro-climatic zones in southern Mali, to characterise P. biglobosa populations. Plots of 0.25 ha each were established in fields and fallows and adult trees in the plots were monitored. Natural regeneration was monitored in five subplots of 12.5 m x 12.5 m = 156.25 m2 each within each plot and data were collected from 2019 to 2021. Natural regeneration of P. biglobosa was found to be very weak in all sites. The mean density of seedlings varied from 11 to 24 seedlings ha-1 with a decreasing trend from 2019 to 2021. In Zanzoni, where the weakest regeneration was observed, the density varied from 0 to 8 seedlings ha-1. The highest density of seedlings was observed in Somasso in 2019 (42 seedlings ha-1) and 2020 (30 seedlings ha-1). In 2021, the highest density was observed in Diou (25 seedlings ha-1). The weakness of natural regeneration is very alarming for this tree species facing several other threats (ageing and decreasing adult tree populations, sanitary constraints, several pressures, etc.). It is therefore very important and imperative to investigate ways for regenerating the species for its sustainability and for maintaining the parklands biodiversity. Artificial regeneration (planting), could be the one and ultimate way to ensure the sustainability of P. biglobosa.
COVID-19 Pregnancies with Heart Disease: Challenges of Delivery
Authors: Anant Monika , Kumar Neeraj , Ahmad Shaheen
Published: October 2022

This case series of four cases of pregnancy with rheumatic heart disease with COVD-19 disease reports on the management of delivery and complications of heart disease with COVID-19, high-lighting the presentation, severity, delivery concerns, and clinical management with the maternal and fetal outcomes. Of the four full-term deliveries, one delivered normally, one instrumental delivery and two by cesarean section. All four required oxygen support post-delivery, 2/4 (50%) were transferred for intensive care unit (ICU) care, 1/4 (25%) required mechanical ventilation, 1/4 (25%) had postpartum hemorrhage, 1/4 (25%) had COVID related sepsis and received convalescent plasma therapy, and 2/4 (50%) received antiviral remdesivir. The most severe disease (COVID sepsis and ICU stay) was seen in patient of heart disease with COVID with preclampsia. All neonates tested SARS-CoV-2 negative, with one early neonatal death. All four mothers were discharged in stable condition of COVID and heart status. COVID-19 in cardiac disease pregnancies has increased rates of complications, oxygen, and ICU requirements than other pregnancies with COVID, requiring multidisciplinary team for intensive monitoring of intrapartum and postpartum period.
Effect of Dapagliflozin on Left Ventricular Diastolic Function in Diabetics - A Prospective Interventional Study
Authors: Jakkula Sri Kiran , Maddury Jyotsna , Nakka Srikanth , Kumar Achukatla
Published: October 2022

Objectives:

In patients with established heart failure, the SGLT2 inhibitor dapagliflozin found to alleviate the risk of worsening heart failure or cardiovascular mortality regardless of the presence of Diabetes Mellitus. To evaluate the effect of Dapagliflozin on Left Ventricular Diastolic function in Patients with Type 2 Diabetes Mellitus, to study the baseline Diastolic function in patients with type 2 diabetes mellitus and to study the Diastolic function at rest and after exercise in patients with type 2 diabetes mellitus 24 weeks after taking Dapagliflozin.

Materials and Methods:

It is a Prospective interventional Pilot study with study population consisting of T2DM who are 18 years and older with HbA1C between 7.0% to 10% and LV diastolic dysfunction of at least grade 1 on resting echocardiography. Baseline diastolic function was measured. Dapagliflozin 10 mg once daily was given to all patients for 24 weeks and then left ventricular diastolic function was measured by e’, E/A ratio, E/e’ at 24 weeks from baseline as assessed by Stress Echocardiography.

Results:

Diastolic Dysfunction grading between Baseline and post 24 weeks treatment with dapagliflozin, using Marginal Homogeneity Test showed p value <0.001 which is highly significant. Comparision of e’ at rest for baseline and post 24 weeks of treatment with dapagliflozin showed statistical significance. The e’ after exercise for baseline and post 24 weeks of treatment showed p value of <0.01. Comparision of E/e’ at rest and after exercise for baseline and post 24 weeks showed statistical significance.

Conclusion:

The diastolic function has been significantly improved after 24 weeks of using dapagliflozin. The diastolic function parameters between age and sex groups at baseline and post 24 weeks of treatment with dapagliflozin does not correlate.
Ulcerating Stasis Dermatitis of the Forearm Associated With Arteriovenous Graft and Central Vein Stenosis
Authors: Guimarães Diogo , Ribeiro Luís , Barata Rui , Mendes Maria , Mendes Marco , Mouzinho Maria
Published: October 2022

Introduction. Stasis dermatitis is a pathologic condition of the skin that most commonly occurs in the lower limb, where it is caused by chronic venous insufficiency. Stasis dermatitis of the upper limb is rare. Case Report. A 45-year-old male, resident in Angola, presented to the emergency department with an ulcer encompassing the entire left forearm. Past medical history comprised arterial hypertension and end stage renal disease treated with hemodialysis. Dialysis access consisted of a left brachial-basilic AV graft obtained 4 years before. The patient also reported that a right internal jugular vein catheter was used previously during the maturation of the left brachial-basilic AV graft. Stenosis of the left brachiocephalic vein was documented at angiography. Angioplasty was performed, with complete resolution of the wound 2 months after admission. Conclusion. The differential diagnosis of extensive ulcer of the forearm must include neoplasms, cellulitis, and/or deep tissue infection with secondary ulceration, but it is also important to maintain suspicion for venous stasis syndrome as a rare but possible cause of these lesions.
Expandable Dehydrated Human Umbilical Cord Allograft for the Management of Nonhealing Lower Extremity Wounds in Patients With Diabetes: A Case Series
Authors: Garoufalis Matthew , Tettelbach William
Published: October 2022

Advanced wound treatments are derived primarily from human placental membranes or animal tissue sources and composed of cellular and acellular dermal substitutes. The use of advanced wound treatments is practitioner directed and individualized to the wound characteristics. A multidisciplinary approach to wound closure is necessary, including the use of advanced treatments (eg, human umbilical cord derivatives) to achieve durable resolution of hard-to-heal wounds. In this case series, DHUC was used as an alternative to amniotic and amnion/chorion allografts for closure of a deep heel ulcer and a wound of the plantar aspect of the foot. The allografts were applied after wound closure had stalled with previous treatment attempts, which demonstrates use of DHUC in a staged approach to wound bed preparation and closure. The thickness and durability of DHUC allowed it to be used more like a skin graft for deep wounds. The meshed product can be expanded to provide a cost-effective solution to cover larger wound surfaces. It can be applied in an outpatient setting, thus avoiding more invasive and costly procedures (eg, split-thickness skin grafts). The use of umbilical allografts in the current report resulted in closure of stalled wounds and avoided hospitalization, thus reducing overall costs.
Product Meaning in Digital Product Innovation
Authors:   Queen’s University, Wang Gongtai , Henfridsson Ola ,   University of Miami, Nandhakumar Joe ,   University of Warwick, Yoo Youngjin ,   Case Western University
Published: October 2022

Digital product innovation involves a meaning-making process. Designers of digital innovations often challenge established product meanings as they digitize physical products, such as cars, toothbrushes, and water bottles. A significant problem for product designers, however, is striking the right balance between the newness and comprehensibility of product meanings. Failure to do so may result in a digital product innovation that is too conventional or difficult to relate to or understand. Yet, the extant digital product innovation literature pays little, if any, attention to product meaning. To fill this void, this study examines a digital product innovation project in which product designers created a digital theater with product meanings beyond those of the traditional movie theater. Our theory, grounded in in-depth data collection and analysis, explains how product designers attribute meanings to their products in the process of digital innovation by enacting two meaning-making loops: a reinforcing loop that makes the product meaning comprehensible, and a differentiating loop that captures emerging product meanings. The two loops come together via meaning sedimentation, through which a new core product meaning is created. Our study contributes to the digital product innovation literature by shedding light on the essential role of meaning-making in innovation and offers an explanatory process theory.
Product Reviews: A Benefit, a Burden, or a Trifle? How Seller Reputation Affects the Role of Product Reviews
Authors:   Lanzhou University, Lanzhou, Wang Hongpeng , Du Rong ,   Xidian University, Shen Wenqi ,   Virginia Tech, Qiu Liangfei ,   University of Florida, Fan Weiguo ,   University of Iowa
Published: October 2022

The sales effect of product reviews has been a contentious issue with competing perspectives about when product reviews serve as a benefit, a burden, or a trifle. Unlike previous research that separately investigates the impact of each eWOM system, our study empirically examines the interaction effects of dual eWOM systems, i.e., product reviews and seller reputation. Drawing on reference point theory, we find that seller reputation systems play a reference-point role and determine the efficacy of product reviews. Specifically, negative reviews cause a significant loss in sales for high-reputation sellers but are less detrimental for low-reputation sellers. In contrast, positive reviews can boost sales for low-reputation sellers but are less helpful for high-reputation sellers. These results highlight that seller reputation is a double-edged sword. While a high seller reputation can reduce seller uncertainty and attract more consumers, it may also raise consumers’ expectations and lead to potential negative expectancy violations. Moreover, we explore what strategies may help mitigate the potentially detrimental effect of reference points for high-reputation sellers. Through the lens of restructuring reference points, the reputation reference effect can be adjusted in a more dynamic reputation system (e.g., a reputation badge). Compared to sellers that have never lost their top-rated badge, sellers that have lost their top-rated badge may face an attenuated detrimental impact on sales from the negative expectancy violation due to negative reviews and enjoy a positive impact from positive reviews. We discuss the implications of our findings for both theory and practice.
Social Capital Accumulation through Social Media Networks: Evidence from a Randomized Field Experiment and Individual-Level Panel Data
Authors:   Goethe University Frankfurt, Weiler Michael , Stolz Simon ,   WHU – Otto Beisheim School of Management, Lanz Andreas ,   HEC Paris, Schlereth Christian ,   WHU – Otto Beisheim School of Management, Hinz Oliver ,   Goethe University Frankfurt
Published: October 2022

Work-related social media networks (SMNs) like LinkedIn introduce novel networking opportunities and features that promise to help individuals establish, extend, and maintain social capital (SC). Typically, work-related SMNs offer access to advanced networking features exclusively to premium users in order to encourage basic users to become paying members. Yet little is known about whether access to these advanced networking features has a causal impact on the accumulation of SC. To close this research gap, we conducted a randomized field experiment and recruited 215 freelancers in a freemium, work-related SMN. Of these recruited participants, more than 70 received a randomly assigned voucher for a free 12- month premium membership. We observe that individuals do not necessarily accumulate more SC from their ability to access advanced networking features, as the treated freelancers did not automatically change their online networking engagement. Those features only reveal their full utility if individuals are motivated to proactively engage in networking. We found that freelancers who had access to advanced networking features increased their SC by 4.609% for each unit increase on the strategic networking behavior scale. We confirmed this finding in another study utilizing a second, individual-level panel dataset covering 52,392 freelancers. We also investigated the dynamics that active vs. passive features play in SC accumulation. Based on these findings, we introduce the “theory of purposeful feature utilization”: essentially, individuals must not only possess an efficacious “networking weapon”—they also need the intent to “shoot” it.
Assessing the role of the Kohn-Sham density in the calculation of the low-lying Bethe-Salpeter excitation energies
Authors: Kshirsagar Aseem Rajan , Poloni Roberta
Published: October 2022

We adopt the GW many-body perturbation theory in conjunction with the Bethe-Salpeter equation (BSE) to compute 57 excitation energies of a set of 37 molecules in order to shed light on the dependence on the initial Kohn-Sham (KS) density functional. By using the PBEh global hybrid and a self-consistent scheme on the eigenvalue, our calculations show a weak correlation between the change in the BSE energies upon variation of the exact exchange fraction (α) and the change in the GW quasiparticle energy of the corresponding electronic levels, pointing to the critical role of the KS electronic density. In order to address the arbitrariness in the mean field choice, we adopt an orbital-tuning scheme where the amount of exact exchange is tuned to fulfill the ionization potential theorem in DFT. The performance of the proposed scheme is found to be similar to M06-2X and PBEh with α=75%, consistent with tuned-values of α ranging between 60% and 80%. Interestingly, the best performers yield systematically smaller errors for n → π∗ excitations than for π → π∗.
BICePs v2.0: Software for Ensemble Reweighting using Bayesian Inference of Conformational Populations
Authors: Raddi Robert , Ge Yunhui , Voelz Vincent
Published: October 2022

Bayesian Inference of Conformational Populations (BICePs) version 2.0 (v2.0) is a free, open-source Python package that reweights theoretical predictions of conformational state populations using sparse and/or noisy experimental measurements. In this article, we describe the implementation and usage of the latest version of BICePs (v2.0), a powerful, user-friendly and extensible package which makes several improvements upon the previous version. The algorithm now supports many experimental NMR observables (NOE distances, chemical shifts, J-coupling constants, and hydrogen-deuterium exchange protection factors), and enables convenient data preparation and processing. BICePs v2.0 can perform automatic analysis of the sampled posterior, including visualization, and evaluation of statistical significance and sampling convergence. We provide specific coding examples for these topics, and present a detailed example illustrating how to use BICePs v2.0 to reweight a theoretical ensemble using experimental measurements.
Fibrils emerging from droplets: Molecular guiding principles behind phase transitions of short peptide-based condensates
Authors: Lipiński Wojciech P. , Zehnder Johannes , Abbas Manzar , Güntert Peter , Spruijt Evan , Wiegand Thomas
Published: October 2022

Biochemical reactions occurring in highly crowded cellular environments require different means of control to ensure productivity and specificity. Compartmentalization of reagents by liquid-liquid phase separation is one of these means. However, extremely high local protein concentrations of up to 400 mg/ml can result in pathological aggregation into fibrillar amyloid structures, a phenomenon that has been linked to various neurodegenerative diseases. Despite its relevance, the process of liquid-to-solid transition inside condensates is still not well understood at the molecular level. In this work, we use small peptide derivatives that can undergo both liquid-liquid and subsequent liquid-to-solid phase transition as model systems to study both processes at the molecular level. Using solid-state nuclear magnetic resonance (NMR) and transmission electron microscopy, we compare the structure of condensed states of leucine, tryptophan and phenylalanine containing derivatives, distinguishing between liquid-like condensates, amorphous aggregates and fibrils, respectively. A structural model for the fibrils formed by the phenylalanine derivative was obtained by a structure calculation based on NMR distance restraints. Our results show that the fibrils are stabilised by hydrogen bonds and side-chain π-π interactions, which are likely much less pronounced or absent in the liquid and amorphous state. Such noncovalent interactions are equally important for the liquid-to-solid phase transition of proteins, particularly those related to neurodegenerative diseases and our results suggest that aged condensates of these proteins may have partial amyloid-like characteristics.
MORTAR - A Rich Client Application for in silico Molecule Fragmentation
Authors: Bänsch Felix , Schaub Jonas , Sevindik Betül , Behr Samuel , Zander Julian , Steinbeck Christoph , Zielesny Achim
Published: October 2022

Developing and implementing computational algorithms for the extraction of specific substructures from molecular graphs (in silico molecule fragmentation) is an iterative process. It involves repeated sequences of implementing a rule set, applying it to relevant structural data, checking the results, and adjusting the rules. This requires a computational workflow with data import, fragmentation algorithm integration, and result visualisation. For a new algorithm, this workflow is normally not available and must be set up individually. In this work, an open Java rich client Graphical User Interface (GUI) application is presented to support the development of new in silico molecule fragmentation algorithms and to make them readily available upon release. The MORTAR (MOlecule fRagmenTAtion fRamework) application visualises fragmentation results of a set of molecules in various ways and provides basic analysis features. Fragmentation algorithms can be integrated as well as developed within MORTAR by using a specific wrapper class. In addition, fragmentation pipelines with any combination of the available fragmentation methods can be executed. Upon release, three fragmentation algorithms are already integrated: ErtlFunctionalGroupsFinder, Sugar Removal Utility, and Scaffold Generator. These algorithms, as well as all cheminformatics functionalities in MORTAR, are implemented based on the Chemistry Development Kit (CDK).
TRANSFORMATIONAL LEADERSHIP FROM THE EDUCATIONAL PARADIGM ON THE PANDEMIC ERA
Authors: Ghifary Muhammad Tahajjudi , anto Sury
Published: October 2022

Background – Changes behavior during a pandemic make the world have to adapt. This condition also occurs in the world of education, where many new habits and procedures are carried out. so the role of leaders is needed in getting through this period. Transformational leadership feels very appropriate in this time of uncertainty and many adaptations. Transformational leadership requires the figure of a leader who is able to show special skills that focus on reform and justice. Purpose – This article aims to understand transformational leadership in the focus of education especially during the pandemic. The world of education must know the right formulation to get through this pandemic so that the next generation of the nation continues to have the opportunity to build their dreams. Design/methodology/approach – This research is a descriptive research with a case study approach. where data is collected based on research observations and in-depth literature studies. Findings – Transformational leadership becomes a bridge between existing theories so it is a valuable asset. Given the diverse needs of individuals, transformational leadership must offer more comprehensive conditions. Research limitations– This research is limited to literature review, so it needs to be developed with more specific research methods and objects so that the results obtained are also more accurate. The selection of research variables can also be redeveloped because there are still many types of leadership in the organization. In addition to leadership, there are also many factors that make up an organization so that further researchers can choose other variables to study. Originality/value – There is not much research on pandemics in the world of education, let alone discussing the role of the leader of an educational institution. With this research, the public knows that the role of the leader of educational institutions is very important in directing their organization to get through this pandemic crisis. how to deal with multicultural challenges, behavior, readiness and achievement demands of school residents in addition to innovating to face the pandemic.
UPSURGE IN ATTACK ON SECONDARY SCHOOLS IN NIGERIA, CAUSES, EFFECTS AND SOLUTIONS: IMPLICATIONS ON EDUCATIONAL ASSESSMENT AND EVALUATION
Authors: Ikpi Eyong Emmanuel
Published: October 2022

The role of secondary education in Nigeria cannot be undermined. This is due to the central position it occupies in the three tiers of education in Nigeria. It has been established that most students who cannot cope effectively in primary school education have the potential to strive efficiently in the secondary level of education. A child without a basis in secondary education cannot survive academically in tertiary education. This underscore why every effort must be put in place to harmonize a well-equipped secondary education in Nigeria. The persistent attack on secondary schools in Nigeria has attracted the attention of stakeholders in the academic environment which has attracted the need for this paper on the upsurge in attacks on secondary schools in Cross River State, Nigeria; causes effect and solution: Implication on assessment and evaluation. Owing the role of secondary education in Cross River State, Particularly in Nigeria. The continuous attack in the form of poor funding, lack of government attention, banditry attack, and issue in students’ seriousness has been a major cause for concern in recent times. The paper x-rayed the causes and possible solutions pointing to the implication of educational assessment and evaluation.
EXPLORATION ON LEGAL BASIS OF REASONABLE OPENING OF LIMITED SURROGACY IN CHINA
Authors: Li Shuo
Published: October 2022

Limited open surrogacy can help many couples of childbearing age solve their fertility problems, which aligns with the basic concept of fairness and justice. Facing the great demand for surrogacy and the chaotic underground surrogacy, China’s attitude toward banning surrogacy is worth pondering. China has permanently attached great importance to ethics, and the complete prohibition of surrogacy is not a good policy. The realization of limited legalized surrogacy needs regulation and the harm brought by limited legalized surrogacy can be avoided as much as possible by restricting the qualifications of the entrusting party, modifying the conditions of surrogate mothers, and strictly reviewing the surrogacy agreement.
Formulation of Quality of Islamic Basic Education: A Study in the Integrated Islamic Elementary School (SDIT) Al Uswah Magetan
Authors: Nasrowi Bagas Mukti , Kholifah Yusnia Binti
Published: October 2022

The development of science and technology that occurs in the current global era has a considerable impact on the changes in human life. These impacts and challenges can be overcome by qualified human resources. Such condition requires educational institutions to continue to improve the quality of their education in order to create qualified human resources. Likewise in Islamic basic education institutions, as the foundation of secondary and higher education, basic education is also in need to continue to improve its quality in order to be able to play a role in facing global changes. Therefore, careful strategy formulation is needed as an effort to make strategic planning in a directed, effective, and efficient manner in the process of improving the quality of Islamic basic education institutions in the current global era. This study examines the formulation of quality of Islamic basic education in SDIT Al Uswah Magetan. The type of research used is a case study. Data collection techniques are used, namely in-depth interviews, participant observation, and study of documents. Data analysis in this study used an interactive analysis model. Then the results of the research are the strategy formulated is focused on curriculum development, human resource development, infrastructure development, environmental development, and student development.
The eye - the window to the soul of the diagnosis: CHARGE Syndrome, a case report
Authors: Hubail Amal Redha , Darwish Jinan Harith
Published: October 2022

The modality of inheritance in CHARGE syndrome is autosomal dominant, classically triggered by mutations in the chromo-domain helicase DNA binding protein-7 (CHD7) gene. CHARGE syndrome is characterized by the variable occurrence of coloboma, heart defects, atresia of the choanae, retarded growth and development, genital hypoplasia, ear anomalies and deafness. In this report, we describe an infant with a typical phenotype characterized by severe psychomotor retardation, facial asymmetry, coloboma, cortical blindness, unilateral choanal atresia, congenital heart anomalies, genital hypoplasia, cranial nerve IX/X dysfunction and global developmental delay that was diagnosed clinically. Following clinical diagnosis a complete sequencing of the CHD7 gene was carried out at the Institute for Medical Diagnostics GmbH in Ingelheim, Germany. Genomic DNA was screened for mutations in the CD7 gene (OMMIM 608892) on chromosome 8q12.1 The codon exon 2-38 and the respective exon-intron boundaries were amplified by polymerase chain reaction and analysed by direct sequencing. Resulting sequence data were compared with the reference sequence NM_017880.3 No mutation in CHD7 gene was detected as a genetic cause for the clinical phenotype of the patient. The MPLA multiplex ligation-dependent probe amplification analysis showed no copy number variation in the CHD7 gene. This case report underscores the importance of a detailed family history and physical examination in the diagnosis of CHARGE syndrome. Additionally, it provides valuable insight into the pathogenesis and clinical presentation of the syndrome as well as highlighting the benefits of a multidisciplinary approach. With supportive nurturing care, children with CHARGE syndrome can overcome the associated disabilities and develop necessary motor skills and a life-style enhancing level of fitness.
CAPITAL INTELECTUAL, GESTIÓN DEL CONOCIMIENTO E INNOVACIÓN MEDIANTE LA INCUBADORA DE EMPRESAS EN UNIVERSIDADES
Authors: COYLA ZELA MARIO AURELIO
Published: October 2022

La educación Superior está siendo transformada de una manera rápida, esencial y vigorosa, debido al impacto de factores como el crecimiento económico basado en el conocimiento y la revolución de las nuevas tecnologías de la información y la comunicación. En grandes líneas, estos factores han significado mayores exigencias de calidad y productividad, el incremento de la competencia entre la universidad pública y la universidad privada, tendencias a la sustitución de las universidades tradicionales por universidades empresariales. La propuesta alcanza a un modelo de producción del conocimiento, aplicación y generación de ingresos a las universidades empresariales. La propuesta alcanza a un modelo de producción del conocimiento, aplicación y generación de ingresos a la universidad e integración de la teoría y la práctica para los estudiantes que deberán participar en las consultoría de las incubadoras en las universidades.
Esteganografía en imágenes digitales aplicando autómatas celulares bidimensionales como generadores seudoaleatorios
Authors: SORIA SOLÍS IVÁN
Published: October 2022

La esteganografía permite codificar información dentro de archivos de imágenes u otros formatos aprovechando las limitaciones de los sentidos, sin embargo, existen técnicas de estegoanálisis que permiten detectar si una imagen ha sido alterada con esta técnica y a la vez existen múltiples técnicas de codificación. Por tanto, este es un campo en constante evolución. El presente estudio combina la esteganografía sobre imágenes digitales en formato PNG y en modo de color RGBA de 32 bits utilizando la técnica del Bit Menos Significativo - LSB, con un generador de bits seudoaleatorio implementado en base a un autómata celular bidimensional que genera secuencias de bits con apariencia de aleatoriedad. El autómata apropiado, según su regla de transición, se determinó mediante simulación para múltiples reglas por ser un modelo impredecible, las secuencias de bits generadas se evaluaron mediante las pruebas estadísticas de Relación de Señal a Ruido de Pico - PSNR y la Entropía Relativa de la estegoimagen. La entropía de las imágenes resultantes de la aplicación de ambas técnicas resultó ser similar a la entropía de las imágenes originales y en consecuencia son difícilmente detectables por las técnicas estadísticas de estegoanálisis incrementándose la seguridad de la codificación.