bluuebunny/crossref_metadata_2025 huggingface dataset:
Microcontroller-based Artificial Lighting to Help Growth the Seedling Pakcoy
Authors: Afandi Mas Aly , Hikmah Irmayatul , Agustinah Chandra
Published: April 2022

Improving efficiency and quality in farming activities is important reason of developing technology to support agriculture. Technology in agriculture such as image processing, Internet of Things (IoT), Artificial Intelligence, Big Data, and Artificial Lighting gives increasing trends. Artificial lighting technology has high impact to support agriculture in an area that has low sun light intensity such as in rainy season. Farmer has a difficulty to cultivating plant especially in early stage in rainy season. This problem happen because of the intensity of sun light is very minimum. Artificial lighting is a technology to solve early stage cultivating problem in rainy season. This technology can support agriculture for cultivating plant with minimum sun light. Artificial lighting contains light emitting diode (LED) that is laid out as an array. This research goal is to make an artificial lighting prototype to support early stage cultivating. Pakcoy is a plant that used to observe artificial lighting impact for early stage Pakcoy cultivation. This research shows Pakcoy plant placed in the prototype gives significant growth compared with a plant which placed in low light room. Pakcoy plant in artificial lighting gives 2 4 leaves, the height is 1.5 5cm, and from 18 seeds 10 is grow. This research can conclude that artificial lighting prototype can support early stage Pakcoy cultivation.
An Automatic Wind Turbine Braking System on PLTH Bayu Baru through a Fuzzy Logic Controller
Authors: Sutikno Tole , Wahid Syahid Hikmatul , Aprilianto Rizky Ajie , Subrata Arsyad Cahya , Jidin Auzani
Published: April 2022

PLTH Bayu Baru is one of the hybrid power plants (HPP) located in Baru beach, Pandansimo, Bantul, Yogyakarta, Indonesia. It generates electrical energy from two sources, wind and solar energy. However, a problem is encountered regarding wind turbine mechanics due to using a manual switch for braking during periods of excessive wind speed. This study proposes an automatic wind turbine braking system through a utilized fuzzy logic controller (FLC) for the PLTH Bayu Baru application. The Mamdani type FLC without complex mathematical models is applied to the Arduino Uno development board to realize the proposed systems. The error (Error_V) and delta error (dError_V) values from the generator voltage sensor become the input of the proposed systems, while the pulse width modulation (PWM) becomes the output for controlling the on/off period of the MOSFET as switching devices. The proposed systems have been tested on a micro-scale wind turbine with PMSG 12V/400W type. From the testing results, the proposed system successfully braked automatically at the point wherein the generator voltage exceeds the setpoint value. Also, the proposed system keeps the generator voltage less than 13.8V, so the problem caused by excessive speed can be resolved.
Real-Time Accident Detection Using KNN Algorithm to Support IoT-based Smart City
Authors: Amiroh Khodijah , Seno Aji Bernadus Anggo , Rahmanti Farah Zakiyah
Published: April 2022

Surabaya is a city with an area of 326.81 km2 and is the center of land transportation in the eastern part of Java Island. The construction of digital infrastructure in the Surabaya area will make it easier for the City Government to make efficient services. Traffic accidents that occurred in Surabaya until 2017 recorded 1,365 incidents. EVAN (Emergency Vehicle Automatic Notification) is a research topic that focuses on the field of transportation, especially in real-time traffic accidents which can be integrated with city information centers and hospitals for primary assistance in accidents. The purpose of this research is to make it easier for the Surabaya city government to provide first aid in the event of an accident. The design of the device on the user side is made using the Arduino, the accelerometer sensor and the gyroscope in the form of the MPU6050 sensor and the u-blox gps module. Crash detection on the system using the k-Nearest neighbors algorithm (KNN). On the operator side, the design is done on a web basis by utilizing the ReactJs framework which is integrated with the Google Maps APIs. The results of the accuracy of the accident detection system reached 97% and the detection of accident locations and the nearest hospital from the location reached 100%. Thus, real-time accident detection can be implemented in Surabaya city to support the smart city.
Evaluation of the safety and efficacy of platelet-rich plasma in the treatment of female patients with chronic telogen effluvium: A randomised, controlled, double-blind, pilot clinical trial
Authors: El-Dawla Reham Ezz , Abdelhaleem Maryam , Abdelhamed Amr
Published: April 2022

Background:

Chronic telogen effluvium is characterised by diffuse loss of hair of the scalp. One of the emerging lines of treatment is platelet-rich plasma. However, not much of published data exist.

Aims:

A pilot study was conducted on chronic telogen effluvium patients to evaluate the efficacy and safety of platelet-rich plasma, and to compare two different methods of platelet-rich plasma preparation.

Methods:

The study included 30 female patients with chronic telogen effluvium. Patients were randomised into three groups: Group (1): Special platelet-rich plasma tubes centrifuged at 3500 rpm; Group (2): Ordinary laboratory tubes centrifuged at 1000 rpm; Group (3): Normal saline as a placebo. Patients' evaluation was done with visual analog scale, hair pull test, trichoscopy, photos, satisfaction questionnaire, and safety. All patients received four monthly sessions. Patients were evaluated one month and three months after the last session.

Results:

The hair pull test,visual analogue scale, and patient satisfaction results showed a statistically significant difference between group 1 vs. group 3 and group 2 vs.group 3 at one and three months after the sessions, while there was no difference between group1 vs. group 2. Trichoscopy results (baseline, one and three months after treatment) showed a significant increase in hair density and thickness in the frontal area, temporal area, and the vertex in groups 1 and 2 only. There was no statistically significant difference between the three groups with regards to side effects.

Limitations:

The sample size was small with ten patients in each group. Furthermore, the follow-up of patients was for only three months.

Conclusions:

Platelet-rich plasma could be considered as a promising therapy for patients with chronic telogen effluvium with an excellent safety profile. The ordinary laboratory low-cost tubes might be a reliable alternative to the expensive special platelet-rich plasma kits tubes. The trial registry number is PACTR202006539654415.
Toward Programmed Molecular Lanthanide Probes and Sensors
Authors: Piguet Claude
Published: April 2022

The peculiar spectroscopic properties of the lanthanide metal ions (4f-block, Lnlll), and particularly Eulll and Tblll, make them suitable for the design of chemical luminescent probes and analytical sensors when Lnlll is introduced into organized molecular architectures possessing controlled and protected coordination sites. The tridentate receptors 2,6-bis(1-alkylbenzimidazol-2-yl)pyridine (Li, i=2-7) play a crucial role since they react with Ln3+ to give mononuclear building blocks [Ln(Li)3]3+ where the metal ion is protected by the wrapping of the aromatic ligands. In these ultraviolet to visible light-converting devices (Ln=Eu, Tb), the size of the internal cavity is controlled by the three closely packed strands which produce i) a promising discrimination between Lnlll according to their sizes and ii) efficient light-harvesting resulting form the strong absoprtion of ultraviolet light by the ligands. These building blocks have been introduced into more sophisticated homodinuclear triple-helical complexes [Ln2(L8)3]6+ and statistical mixtures containing the heterodinuclear directional visible to visible light-converting device [EuTb(L8)3]6+. Improved molecular programming results form the use of acyclic segmental ligand possessing different binding units coded for one particular ion. The segmental ligands Li (i=9,10) discriminate Fell and AgI to give the heterodinuclear double helicate [FeAg(L10)2]3+ and the heterotrinuclear organometallic [2]-catenate [FeAg2(L9)2]4+ where each metal ion occupies a coordination site satisfying its stereochemical requirements. The receptor L11 recognizes 3d- and 4f-block metal ions to give the heterodinuclear d-f-triple-helical complexes [LnZn(L11)3]5+ where Znll occupies the pseudo-octahedral capping site and corresponds to a noncovalent tripod which properly organizes the strands for their coordination to Lnlll. In these new self-assembled lanthanide podates, predetermined structural and physical properties result form i) the judicious choice of the d-block ion associated with Lnlll and ii) the design of the tridentate unit bound to Lnlll. [LnFe(L11)3]5+ (Ln=La-Eu) display thermochromism and spin-crossover behavior while light emission can be increased by a factor 104 when going from [EuZn(L11)3]5+ to [EuZn(L12)3]5+. The design of tailored receptors for the preparation of stable lanthanide light-converting devices is discussed together with new characterization methods applied to complicated assembly processes in solution.
Die Entwicklung eines neuen, umweltgerechten Produktionsprozesses für Terbinafin
Authors: Beutler Ulrich , Mazacek Jan , Penn Gerhard , Schenkel Berthold , Wasmuth Daniel
Published: April 2022

An efficient process for the production of terbinafine is described. Starting from (E)-I,3-dichloropropene, neohexene, and N-methyl-( I-naphthylmethyl)amine and using a palladium-catalyzed coupling methodology, terbinafine is produced exclusively as (E)-isomer in a convergent manner. The new process avoids the very toxic and nasty starting materials acrolein and phosphorus pentachloride used in the old process.
Total Synthesis and Structural Studies of the Antiviral Marine Natural Product Hennoxazole A
Authors: Wipf Peter , Lim Sungtaek
Published: April 2022

A concise synthetic strategy and the structure elucidation of hennoxazole A are presented. A meta-xylene degradation is used to construct the pyran segment, and the preparation of the skipped polyene moiety is accomplished via asymmetric reduction of β-stannyl enone, an SN2 displacement of an allylic trimethylbenzoate with vinyl cuprate, and coupling of a vinyl-zinc reagent with a π-allyl palladium species. The final steps of the convergent total synthesis of (2S,4S,6S,8S,22R)-hennoxazole A involve an amide coupling followed by the construction of the bisoxazole core. The combined use of circular dichroism, total synthesis, and optical rotation serves to unequivocally establish the relative and absolute configuration of the marine natural product. A new empirical CD helicity rule is proposed that allows the assignment of bisallylic stereocenters in acyclic homoconjugated dienes. In addition, an independent proof of the configuration of hennoxazole A is based on an extensive study of van't Hoff's principle of optical superposition. This chiroptical analysis employs the additivity of the molar rotation [Φ] of the individual stereocenters.
Beispiel für die Evolution der Synthese eines Entwicklungsproduktes: Herstellung des als 5 HT2C/2B-Receptor-Antagonisten wirksamen Indolo-naphthyridin-Derivates SDZ SER-082 in enantiomerenreiner Form
Authors: Mühle Herbert , Nozulak Joachim , Cercus Jacques , Küsters Ernst , Beutler Ulrich , Penn Gerhard , Zaugg Werner
Published: April 2022

cis-4,5,7a,8,9,10,11,11a-Octahydro-7H-10-methylindolo[1,7-bc][2,6]naphthyridine (rac-4) (SDZ SER-082) is a selective and potent 5-HT2C/2B receptor antagonist, exerting weak affinity towards the 5-HT2A receptor site. The compound 4 was found to be a potential development candidate in several CNS indications. The key step in the initial synthesis was the photocyclization of the indolyl tetrahydropyridino-carbamic acid ethyl ester 1 to afford the cis/trans-naphthyridine 2/3. This process turned out to be inefficient for a scale-up. Three alternative synthetic routes A, B and C are discussed: The 'Imino-Diels-Alder' reaction applying indoline/formaldehyde/cyclopentadiene (route A) and the intramolecular Heck cyclization of 7-bromo-2,3-dihydro-1-[(1,2,5,6-tetrahydro-1-methyl-4-pyridyl)-carbonyl]-1H -indole (10) (route B) were surpassed in their synthetic efficiency by the Friedel-Crafts cyclization of 4-(2,3-dihydroindole-1-carbonyl)-1-methylpiperidin-3-one (16) (route C), followed by reduction to give rise to the racemic naphthyridine rac-4. It was subjected to resolution by applying a kg scale repetitive chromatography on a chiral stationary phase to give (+)-(7aS,11aR)-4 in over 90% yield and 99.9% enantiomeric purity.
Consideration of Solid-Phase Synthesis with Reference to Quinolone Antibiotics
Authors: Macdonald Alasdair A. , DeWitt Sheila H. , Ramageu Robert
Published: April 2022

The general utility of solid-phase synthesis for creating libraries of compounds will be discussed with particular reference paid to the development of a solid-phase organic synthetic route to quinolones. Using the DIVERSOMER® technology a library of quinolones have been
prepared, purified and analyzed. Additionally, the issue of resin impurities and by-products will be discussed.
Climate-Resilient Urban Design from a Biomimicry-Arcology Perspective
Authors: Yong Gabriel Y V
Published: April 2022

Global climate action initiatives have focussed on either climate mitigation or adaptation in the decarbonisation agenda. The impact of urbanisation is generally overlooked. Urban development alters the environment, including climate, in multiple ways. Therefore, climate actions are unlikely to succeed, even if its goals are achieved, largely because the current paradigm promotes expansion at the expense of nature. This paper presents an alternative perspective on urban design with respect to climate resiliency. It draws primarily from the thoughts that underpin Arcology and Biomimicry from a complex, evolving Earth systems paradigm. It argues that urban development must shift from 2-dimensional gigantism to a compact 3-dimensional form. It further posits that the structure should facilitate greater exchanges, drawing together complementary elements in economy, industry and society, and services into the same structure. Hyper-structures, multi-functional infrastructures, and systems, are required to drive the transition towards a more efficient, low-impact urbanisation paradigm that frees the land for nature to recolonize. Biomimicry provides suitable models and guides through species that thrive as well as biomes that have developed in the range of environmental and climatic regions on the planet. A viable approach would be to build on existing transport infrastructure.
The first finding of sockeye salmon Oncorhynchus nerka (Walbaum) in the Bolshaya River on Zavyalov Island
Authors: Gorshunov M. B.
Published: April 2022

The sockey salmon entry to the Bolshaya River on Zavyalov Island in the northern Okhotsk Sea was registered for the first time on July 26, 2021. Larger specimens were observed among the pink salmon going to spawn in this river, and one of them was caught by a brown bear at a distance of 300 m from the river mouth. It was the female of sockeye salmon Oncorhynchus nerka (Walbaum, 1792); the data on its size and weight are presented.
Results of experimental studies on suppressing the growth of micromycetes (fam. Saprolegniaceae) on egg membranes of embryos of russian sturgeon and beluga in the incubation period
Authors: Barinova V. V. , Bahareva A. A. , Perunova M. E.
Published: April 2022

For successful development of aquaculture, fish farms have to be provided by effective means and methods to prevent and treat diseases of fish. Many drugs are limited for using in aquaculture, so the influence of each particular drug or chemical substance on the fish development should be investigated carefully. Effectiveness of chemical solutions for suppressing the growth of saprolegnium micromycetes on egg membranes and other tissues of sturgeon embryos during their incubation is evaluated. The experiment was conducted at the research and experimental base BIOS belonged to the Russian Res. Inst. of Fisheries and Oceanography, Volga-Caspian branch (CaspNIRKh) located in Astrakhan and included a series of observations on incubation of sturgeon eggs processed with solutions of some chemicals (Purple-K, sodium chloride, hydrogen peroxide) or drug (Iodinol). Two sturgeon species (russian sturgeon and beluga) were tested with measuring biological parameters of their embryos, as survival rate, contamination by saprolegnia micromycetes, number of abnormally developing embryos, and number of obtained prelarvae. The processing with 0.05 % solution of hydrogen peroxide (10 min. exposure) and with 0.90 % solution of sodium chloride (3 min. exposure) showed the best results: these solutions made the lowest negative effect on the embryos survival but reduced significantly infection of incubated eggs.
Long-term dynamics of forage base and food supply for nekton in the upper epipelagic layer of the western Bering Sea. Part 1. Composition and abundance of zooplankton and small-sized nekton
Authors: Naydenko S. V. , Somov A. A. , Kuznetsova N. A. , Shebanova M. A.
Published: April 2022

An updated concept for the state, dynamics, and production of plankton communities in the upper epipelagic layer of the western Bering Sea is presented based on the timeseries for 1986–2020. The zooplankton biomass in summer exceeded the biomass in fall season in 1.3–2.1 times for the layer of 0–50 m and in 1.1–1.8 times for the layer of 0–200 m, mostly because of decreasing abundance of copepods and chaetognaths that was not compensated by slight increase of the euphausiids and amphipods biomass. Interannual variations were higher and reached 2–3 times and 4–5 times, respectively. Abnormal blooming of certain ecological groups of zooplankton (either warm-water or cold-water) occurred in the anomalous years. Species structure of zooplankton community varied in dependence on oceanographic conditions, generally toward higher abundance in warmer environments. In spite of considerable impact of thermal regime, this dependence was not close and even was absent in some cases that indicated a complex organization of zooplankton communities subjected to influence of many environmental factors. Mean total biomass of large-sized zooplankton and micronekton (prey for large-sized nekton) in the upper epipelagic layer of the western Bering Sea is estimated as 41 . 106 t in summer and 24 . 106 t in fall season, its total production as 101 . 106 t and 67 . 106 t, respectively. In summer, production of non-predatory zooplankton (phyto- and euryphages) prevailed over the predatory zooplankton production, with exception of 2009 and 2013. On the contrary, production of zoophages prevailed in autumn due to successive seasonal changes in the epipelagic plankton communities. These modern data on biomass and production of the zooplankton communities indicate significant reserves of food resources for fish and squids in the deep-water Commander Basin, western part of the Aleutian Basin, and in the area at Cape Navarin.
Long-term dynamics of forage base and food supply for nekton in the upper epipelagic layer of the western Bering Sea. Part 2. Food supply for nekton
Authors: Naydenko S. V. , Somov A. A.
Published: April 2022

Interannual dynamics of feeding conditions for nekton in the upper epipelagic layer of the western Bering Sea is considered for the summer and fall seasons of 2002–2020. In the summers, daily consumption by fish and squids ranged from 0.01 to 0.10 t/km2 in the deepwater basins and between 0.01–0.38 t/km2 in the shelf area at Cape Navarin. In the falls, the consumption increased to 0.03–0.14 t/km2 in the deep-water basins, and to 0.01–0.53 t/km2 in the Navarin area. Summary in the summer-fall periods, the fish and squids consumed 2–5 % of zooplankton production (up to 5–7 % in some years) in the deep-sea basins that is rather low degree of the zooplankton resources usage. In the Navarin area, the consumption is considerably higher and is estimated as 5 % in summer and 21 % in fall season, on average. In cases of heightened nekton biomass and reduced zooplankton biomass in some years, the grazing pressure on plankton increased, in particular on euphausiids, hyperiids and pteropods, while the intensity of salmon feeding decreased, with extension the portions of nektonic food and other zooplankton groups, as arrowworms, in their diet. On the other hand, the portion of juvenile fish and squids in the salmon diet increased in cases of high abundance of this prey, too. Weak correlation was detected both between the salmon feeding and abundance of their prey and between the salmon feeding and abundance of salmons. The feeding conditions for pink salmon during their offshore migration did not determine the rate of their returns. Strong year-classes of pink salmon had large returns in conditions of either poor or rich food supply in fall season, so the feeding in fall was not important for the pink salmon survival in the ocean in winter. Feeding of other fish and squids species did not change noticeably in the years with reduced food supply. In general, abundance and species composition of plankton and nekton communities were rather stable in the western Bering Sea in the 2000-2010s, and this current state of the ecosystem provides stable functioning of nekton communities both in the deepwater and Navarin areas.
Modern state for stocks of Sakhalin-Hokkaido herring Clupea pallasii at the coast of Sakhalin Island and southern Kuril Islands
Authors: Ivshina E. R.
Published: April 2022

Data of bottom trawl surveys at southwestern Sakhalin and surveys of the herring spawning grounds at southern Sakhalin and Kuril Islands are summarized, with assessment of the spawning grounds size and the eggs density in clutches. Fishery statistics and media reports are overviewed, as well. The stock of the Sakhalin-Hokkaido population increases since 2015, both off southwestern and southeastern coasts of Sakhalin, in the Aniva Bay, and at southern Kuril Islands. Number of the spawning herring increases everywhere within the Russian waters, as well as the size of spawning grounds and the density of eggs laying. In particular, the biomass of spawning herring was estimated in 2020 as 35.5 . 103 t at southwestern Sakhalin and 62.5 . 103 t at southeastern Sakhalin; it was 21.6 . 103 t in the Aniva Bay in 2021; the total catch of herring in the waters at Sakhalin Island and southern Kuril Islands reached 8.3 . 103 t in 2021. The stock of Sakhalin-Hokkaido herring is restoring after long depression, so this species is capable to return to the list of the major objects for fishery in the Sakhalin- Kuril region of Russia.
A Study of Correlation of Serum Uric Acid Levels With Diabetic Complications
Authors: Mahitha M  , Mahendra Kumar K
Published: April 2022

Diabetes is the leading cause of adult blindness, end stage renal disease, coronary heart disease, stroke, foot ulcers and lower limb amputations. Serum uric acid levels independently predict the development of macro vascular and micro vascular complications. In this study we analyse the association of serum uric acid with the macro and micro vascular complications of diabetes. In this hospital based observational study, hundred diabetic patients were included; of which fifty had complications, the remaining fifty had no complications. Blood investigations including fasting and post prandial blood sugars, glycosylated haemoglobin, serum creatinine, micro albuminuria, lipid profile, serum uric acid were done in all patients. All the parameters were compared between the two groups. Males with complications had significant high uric acid than females with complications. HbA1c, total cholesterol levels, micro albuminuria, serum creatinine had a positive correlation with the serum uric acid. Uric acid levels were higher among patients with complications compared to patients without complications which was statistically significant (p =0.00001). Patients with nephropathy, retinopathy and coronary heart disease had elevation in serum uric acid levels which was statistically significant. Patients with complications had higher uric acid levels than patients without complications.
The effectiveness of Nusantara Instrumental As Music Therapy for Decreasing Pain In the First Stage of Labor
Authors: Amerry Yenny , Novita Regina Vidya Trias , Susilo W Hary
Published: April 2022

Labor pain is a series of physiological factors due to uterine contractions and cervical dilation along with mental and emotional factors. One of the non-pharmacological pain reduction techniques is music therapy in the form of Nusantara instrumental music. The research objective was to determine the differences in the distribution of music therapy on the intensity of pain during active labor in the delivery room of a private hospital in Bekasi. This study used quantitative methods and a quasi-experimental design with intervention and control. The research was conducted in June-August 2020 with a sample of 80 respondents divided into 60 intervention groups and 20 control groups. The inclusion criteria were pregnancy at term, cervical opening more than 3 cm, not under the influence of analgesic drugs, mothers who were in the caesarean section after the intervention. The results of statistical analysis using the Mann-Whitney test, a p-value of 0.000 (p <0.05) means that there is a difference in the intensity of labor pain during the active phase of the first stage mother between the intervention group and the control group.. Music therapy can be an alternative non-pharmacological nursing intervention for mothers in childbirth, so the mothers are able to control their pain and have a positive experience in childbirth
Self-care management education increase quality of life of patient with chronic kidney disease undergoing hemodilysis
Authors: Prastiwi Dani , Martyastuti Nonik Eka , Isrofah Isrofah , Alisyahbana Barzen
Published: April 2022

Chronic kidney disease and its progression to terminal disease are a significant source of decreased quality of life. One of the efforts that can be done to improve the quality of life is self-care management. This research is Quasy Experiment research with one group pre and post-test design. Twenty-nine people were involved as respondents. The KDQoL SFTM 1.3 questionnaire was used to measure the quality of life before and after treatment. Data were analyzed using paired sample t-test. The average quality of life pretest score was 50.80 ± 8.47 and the average quality of life post-test score was 56.56 ± 10.13 with p-value = 0.024 <0.05. There is an effect of self-care management on the quality of life of patients with chronic kidney disease undergoing hemodialysis. Nursing practice to improve services by providing self-care management education in a programmed and comprehensive manner in patients with chronic kidney disease undergoing hemodialysis.
Reduction of pain in patients with knee osteoarthritis by using hip abductor strengthening exercise
Authors: Fahmi Faradisa Yuanita , Fatikhah Fatikhah , Warsono Warsono
Published: April 2022

Osteoarthritis is a chronic disease that affects the joints and bones around the joints and is often characterized by pain. One type of exercise that can be given to knee osteoarthritis is hip abductor strengthening exercise as a combination of strengthening the quadriceps muscle. This study aimed to determine the effect of Hip Abductor Strengthening Exercise on reducing pain & muscle strength in patients with Knee Osteoarthritis at Kendal Health Center 1. The design of this research is Quasi Eksperimen with design pretest and posttest with the control group. The statistical test of hip abductor strengthening exercise on pain reduction was obtained with a p-value of 0.00. The statistical test of the hip abductor strengthening exercise on the muscle strength value was obtained with a p-value of 0.00. Hip abductor strengthening exercise is an important part of the management of knee osteoarthritis patients. This exercise aims to reduce pain and strengthen knee muscles in osteoarthritis sufferers. There is an effect of hip abductor strengthening exercise on reducing pain & muscle strength in patients with knee osteoarthritis at Kendal Health Center 1.
Implementation of Family-Based Disease Management Model through Community Empowerment
Authors: Muchtar Murniati , Amri Lola Felnanda , Tasman Tasman , Agritubella Syafrisar Meri
Published: April 2022

Efforts to improve the degree of public health are carried out by applying various approaches, including involving the potential of the community in disease management with a family approach. The purpose of this study was to analyse the effect of implementing family empowerment models on increasing family knowledge about healthy families in Nanggalo Padang. The research design was Quasy Experiment research, one group pretest and posttest design. The sample in the study was 30 people using the purposive sample technique in their families who visited Posyandu in 3 villages, namely, Gurun Laweh, Kurao Pagang and Surau Gadang Villages. The community empowerment model used is the Family-Based Disease Management Model developed by Mardikanto. The result showed that there was an effect of the application of the community empowerment model on family knowledge about healthy families (p-value = 0.000). The recommendation of this study is that it is necessary to periodically evaluate the understanding and knowledge of health and family cadres for indicators of healthy families in the community.
PENGEMBANGAN E-MODUL SISTEM PENCERNAAN BERBASIS INKUIRI UNTUK PESERTA DIDIK KELAS VIII DI SMPN 01 JENEPONTO
Authors: Suryadi A. Fitriani , H Anita
Published: April 2022

E-modul merupakan panduan yang memiliki fitur yang aman serta mudah dalam diakses untuk berkomunikasi dan berkolaborasi baik antar siswa dan guru. Tujuan pengembangan E-modul sebagai pendampingan terhadap pendidik terhadap pemanfaatan fasilitas alat elektronik baik itu handphone maupun komputer tergantung kondisi pembelajaran terlebih di era pandemi COVID-19 pengembangan ini dapat membantu proses belajar dengan baikdan secara mandiri. Jenis penelitian yang digunakan merupakan penelitian dan pengembangan (R&D) yang sesuai dengan tujuan dalampengembangan E-Modul Sistem Pencernaan Berbasis Inkuiri Kelas VIII SMPN 10 Jeneponto yang telah diuji pada segi validitas, kepraktisan dankeefektifan. Penelitian dan pengembangan mengacu pada model 4-D tahapan yaitu (Define, Design, Development, Disseminate). Tujuan penelitian terdiri dari tiga rumusan yakni (1) Uji validitas pada instrumen penilaian uji validitas modul serta instrumen penilaian validitas pada angket, (2)Kepraktisan indikator terhadap instrumen angket respon guru dan respon siswa pada E-modul, (3) Uji keefektifan pada instrumen evaluasi tes terhadap hasil belajar siswa. Metode penelitian terdiri atas jenis penelitian, desain penelitian, batasan istilah, prosedur penelitian, instrumen penelitian, dan teknik analisis data. Hasil dari penelitian dari ketiga aspek yang dilakukan setelah di analisis   data   tentang   kevalidan, kepraktisan dankeefektifan E-modul sistem pencernaan berbasis discovery learning memenuhi kriteria.
POTRET PEMBELAJARAN DARING MAHASISWA UNIVERSITAS SINGAPERBANGSA KARAWANG DI TENGAH PANDEMI COVID-19
Authors: Nurfaida Afifah
Published: April 2022

Tujuan penelitin ini adalah untuk memperoleh gambaran mengenai kegiatan proses pembelajaran PJJ (Pembelajaran Jarak Jauh) yang dilakukan oleh mahasiswa UNSIKA di tengah pandemi covid-19 dan menganalisa faktor-faktor yang menjadi kendala mahasiswa dalam proses pembelajaran jarak jauh. Subjek Penelitian ini adalah seluruh mahasiswa UNSIKA. Metode penelitian yang digunakan oleh peneliti berupa kusioner sebagai pengumpulan data yang dilakukan dengan cara memberikan seperangkat pertanyaan melalui Google Form kepada mahasiswa UNSIKA yang dijadikan responden untuk dijawabnya. Hasil penelitian menunjukan bahwa: (1) Dilihat dari aspek kognitif, afektif, dan psikomotor yang dimiliki mahasiswa UNSIKA ketika melakukan proses pembelajaran jarak jauh di masa pandemi covid-19 sangat menurun. (2) Kendala yang dirasakan mahasiswa UNSIKA ketika pjj, seperti susah mencari sinyal, ketidak siapan dalam menggunakan aplikasi-aplikasi untuk komunikasi secara daring, dan keadaan dirumah yang kurang nyaman sehingga dapat menghilangkan fokus dalam pembelajaran. (3) Dampak positif yang dirasakan oleh mahasiswa UNSIKA dalam melakukan kegiatan PJJ seperti mahasiswa lebih aktiv dalam membantu orangtua dirumah dan dapat memberikan manfaat yaitu meningkatkan kesadaran untuk menguasai kemajuan teknologi saat ini dan mengatasi permasalahan proses pendidikan di Indonesia. Kualitas kontrol mutu pendidikan menjadi tantantangan tersendiri bagi pendidik maupun peserta didik dalam penyesuaian pembelajaran yang tradisonal berubah menjadi fleksibel dan dapat membuat sebagian pelajar mulai resah. PJJ (Pembelajaran Jarak Jauh) dinilai cukup efektif untuk mencegah penyebaran Covid-19 di lingkungan pendidikan.
EFEKTIVITAS PEMBELAJARAN KOOPERATIF TIPE TEAMS-GAMES-TOURNAMENT (TGT) DENGAN MENGGUNAKAN MEDIA ULAR TANGGA BANGUN DATAR TERHADAP PEMAHAMAN KONSEP SISWA
Authors: Barumbun Mardyanto
Published: April 2022

Penelitian ini bertujuan untuk menguji dan mengetahui efektivitas pembelajaran kooperatif tipe TGT dalam meningkatkan pemahaman konseptual siswa kelas tujuh pada materi bangun datar dengan menggunakan alat permainan ular tangga bangun datar. Jenis penelitian ini merupakan penelitian kuantitatif menggunakan metode pendekatan pre-eksperimental dengan desain one-group pre-test-post-test yang melibatkan satu kelas VII di SMP Negeri 29 Makassar yang beranggotakan 29 siswa. Data dikumpulkan menggunakan instrumen tes pemahaman konsep geometri, angket respons siswa, dan lembar observasi. Data yang dikumpulkan kemudian dianalisis secara deskriptif dan inferensial. Hasil analisis data menunjukkan bahwa (1) rata-rata pemahaman konsep siswa setelah pembelajaran mencapai 86,21%. Bahkan, terdapat peningkatan pemahaman konsep secara signifikan sebelum dan setelah diterapkannya pendekatan pembelajaran dengan bantuan media tersebut. (2) Terdapat respons positif dari siswa terhadap proses pembelajaran dengan pemanfaatan media di dalamnya. Hasil analisis tersebut menunjukkan bahwa Pembelajaran Kooperatif Tipe TGT menggunakan media Ular Tangga Bangun Datar efektif meningkatkan pemahaman konsep siswa Sekolah Menengah Pertama (SMP) terkait geometri bangun datar.
ANALYSIS OF PEDESTRIAN CROSSINGS FACILITIES AND PEOPLE'S BEHAVIOR ON CROSS THE STREET AT SEGMENT IR. H. JUANDA JAMBI CITY
Authors: Yamali Fakhrul Rozi , Setiawan Ari , Ari Prasetyo Muhamad Fikry
Published: April 2022

Road users are an important part of the government's attention. Road users have the right to the availability of supporting facilities in the form of sidewalks, crossing places and other facilities.Road users must get the main attention when crossing the road on the crossing, and in the absence of the facilities referred to earlier, the user the road has the right to cross at the place chosen by paying attention to their safety. The analysis is carried out by adding up the volume of pedestrians and adding up the traffic volume to choose the appropriate means and meet the requirements at the location. The measuring steps used to select the means of crossing are the volume of pedestrians and traffic, vehicle speed, headway time, road user speed, road capacity, and degree of saturation. The survey runs in three days, namely working days, namely Mondays and Thursdays, and holidays, namely Saturdays. From the data analysis in the field, it can be concluded why the research location requires a pelican cross crossing facility, because all measurements fulfill the requirements to build the crossing to support comfort, safety, and smooth road flow at the site.
PREDICTION OF ROAD CLEARANCE
Authors: Bartholomeus  , Pasaribu Humisar
Published: April 2022

One method of handling soil that can be done to speed up the consolidation process is to add a Pre-Loading embankment on top of the plan embankment. In addition, this handling is also carried out to achieve a reduction by the design load, so that the settlement of embankment after the construction period still meets the required criteria and standards. This study was conducted to obtain a comparison of the prediction of embankment settlement with the empirical method using CPT data and the prediction of settlement using the Asaoka Method. In addition, the results of the consolidation coefficient will also be compared which can be used to determine the right time for Pre-Loading excavation during the construction period. The data used are CPT test data in the field as well as laboratory test data and measurement data for the settlement plate settlement closest to the position of the CPT test. From the analysis carried out, it is obtained that the prediction of decline using the Asaoka method is smaller than the prediction of decline using the empirical method using CPT data. In addition, from the analysis, it was found that at locations HB-04 and SP 70, as well as HB-07 and SP 91, showed laboratory consolidation coefficient values (cv-Lab.) which were close to the consolidation coefficients of the Asaoka Method (cv-Asa.), while in HB -05 and SP 79 and HB-06 and SP 85 show a large difference in values. The average comparison of the cv-Lab. consolidation coefficients and CV-Asa. is 58.5%.
Cholesterol and its biological significance. Atherosclerosis. Statin therapy (Part 1)
Authors: Vasiliev A. P. , Streltsova N. N.
Published: April 2022

Despite the profound development of the theory explaining atherosclerosis pathogenesis, many questions still remain open. Modern ideas about the nature of atherosclerotic lesions in the vascular wall are largely based on the results of N.N. Anichkov’s research where hypercholesterolemia is considered the key point. Numerous theories of atherosclerosis have been proposed to date. However, the lipid-infiltrative idea, established over 100 years ago, remains dominant, and, despite the involved controversies, this concept lays the foundation for the therapeutic and preventive measures in cardiovascular diseases.

Aim. The purpose of this review is to remind the reader of the biological significance of cholesterol, which performs essential vital functions in the body; to discuss some controversial points of view and contradictory facts regarding the etiological role of hypercholesterolemia in atherogenesis, which call into question the appropriateness of using blood cholesterol content as an indicator of disease severity and the possibility to assess the treatment effectiveness based on cholesterol level dynamics.
Imaging of early vasogenic edema in hyperperfusion zones of venous ischemic stroke
Authors: Semenov S. E.
Published: April 2022

Aim. The aim of the study was to investigate the features of cerebral edema in cases of venous ischemic stroke with cerebral venous sinus thrombosis.

Material and Methods. The study included 33 patients with venous stroke as a result of cerebral venous sinus thrombosis. Comparison group comprised 33 patients with arterial ischemic stroke. The control group included 33 individuals. Neuroimaging included native computed tomography (CT) of the brain at admission and at days 5–7, perfusion CT (MSCT 64) within the first 40 minutes of admission to the hospital, and magnetic resonance imaging (MRI) of the brain (1.5T) within the first 24–48 hours of the disease.

Results and Discussion. The relationships were found between the early intercellular edema development according to diffusion MRI and a signal inversion on diffusion-weighted imaging (DWI) (a decrease in the perifocal zone against the background of a high signal of cytotoxic edema), an increase in the signal with the average upper limit of apparent diffusion coefficient (ADC) range (0.82 ± 0.05) * 10-3 mm2 /s differing only from the central zone, and moderate plethora of perifocal zones (with an increase in rCBV and rCBF by 27–28%) according to perfusion CT. These phenomena could be unfavorable factors for the development of edema and probable hemorrhage (in 27% of cases in venous stroke versus 9% in arterial stroke), but were accompanied by a more favorable clinical outcome of venous stroke (improvement in 66% of cases with a complete regression of neurological deficit in 25% versus 57% without complete regression of symptoms in arterial) with a lower incidence of necrosis/infarction (in 50% of cases versus ¾ of cases of ischemic stroke). The presence of a significant correlation between the parameters of lesion area and the relative values of CT-based perfusion and MRI-based diffusion (r = 0.44; p < 0.05) suggested that the early vasogenic edema and hyperemia were the elements of a pathophysiological mechanism for the development of cerebral venous ischemia, which, unlike arterial ischemia, is secondary in nature, associated with mechanical arterial vasoconstriction due to intercellular edema.

Conclusion. Probably, vasogenic edema in most cases of venous stroke, developing almost simultaneously with cytotoxic edema, does not reach the peak of pathological changes and stop in development at the stage of ionic edema with a functional impairment of permeability of the anatomically intact blood-brain barrier when it can reverse. The progressive development of vasogenic edema is a factor for the deepening of ischemia to necrosis/infarction and secondary hemorrhagic transformation.
The prevalence of ischemic pattern of heart damage in patients with acute myocardial infarction depending on the presence of obstructive coronary artery disease: Magnetic resonance study
Authors: Mochula O. V. , Vorobeva D. A. , Ussov W. Yu. , Zavadovsky K. V.
Published: April 2022

Currently, there are practically no works that are devoted to the analysis of different types of damage to ischemic and nonischemic patterns in patients with acute myocardial infarction (AMI), depending on the nature of atherosclerotic lesions of the coronary arteries.

In this regard, the aim of this work was to evaluate the frequency of ischemic pattern of heart damage in patients with AMI depending on the presence of obstructive coronary artery disease.

Material and Methods. The study retrospectively included patients with a working diagnosis of acute coronary syndrome (ACS) who underwent contrast-enhanced cardiac magnetic resonance (MR) imaging (CMR) during the first week after hospitalization. A 1.5 T CMR was performed using a standard protocol. T2-WI, T1-WI, and IR-images were visually assessed for edema and scar/necrosis, respectively. The pattern of acute ischemic damage to the left ventricular (LV) myocardium was an increase in the signal intensity on T2-WI as a sign of myocardial edema and late gadolinium enhancement (LGE) with a typical ischemic nature of contrast enhancement: subendocardial/subtransmural/transmural. The non-ischemic nature of myocardial injury was defined as intramyocardial/subepicardial LGE.

Results. Based on invasive coronary angiography (ICA) data, patients were divided into two groups: group of myocardial infarction (MI) and coronary artery disease (MICAD group) and group of MI and non-obstructive coronary arteries (MINOCA group). It was found that the frequencies of occurrence of subendocardial pattern of cardiac LGE in early CMR did not differ in the groups of AMI patients against the background of obstructive and non-obstructive coronary artery disease (CAD). The most characteristic MR-pattern in MICAD patients was transmural LGE, including that in combination with microvascular obstruction (MVO). The most characteristic MR-pattern in MINOCA patients was mid-wall/insertion point LGE. Subepicardial LGE occurred with equal frequency in MICAD and MINOCA patients.

Conclusion. The most pathognomonic MR-pattern of myocardial damage in AMI against the background of obstructive CAD was the transmural type of LGE with or without the phenomenon of MVO. Identification of the subendocardial type of LGE in patients with MINOCA allowed to stratify these patients into a higher risk group with a further change in treatment tactics.
Immediate results of off-pump versus on-pump coronary artery bypass grafting using autoarterial conduits in situ and Y-graft configurations
Authors: Muradov A. G. , Efendiev V. U. , Andin A. V. , Drobot D. B. , Sakovich V. A.
Published: April 2022

Aim. To compare the immediate results of off-pump versus on-pump coronary artery bypass grafting (CABG) using autoarterial conduits.

Material and Methods. From January 2018 to September 2021, 178 coronary artery bypass grafting operations using autoarterial conduits were performed in the Department No. 1 of the Federal Center for Cardiovascular Surgery (Krasnoyarsk). The operation was performed on a beating heart in 88 patients (group 1) and using cardiopulmonary bypass in 90 patients (group 2). The majority of patients were males in both groups: 76 (86.3%) and 75 (83.3%) patients (p = 0.287). The patients were comparable in age (61.6 ± 7.7 and 60.2 ± 7.5 years, p = 0.237), body mass index (30.9 ± 5.7 and 29.8 ± 5, p = 0.18), and the presence of concomitant diabetes mellitus (30 (34%) and 19 (21.1%), p = 0.052). There were significantly more patients with hemodynamically significant lesions of the brachiocephalic arteries in group 1 (27 (30.7%) versus 13 (14.4%), p = 0.009) and calcification of the ascending aorta (24 (27.3%) versus 11 (12.2%), p = 0.011). The number of hemodynamically significant affected coronary arteries did not differ between the groups: 2.6 ± 0.7 versus 2.5 ± 0.5 (p = 0.393).

Results. Both internal thoracic arteries were used in situ or in the form of Y-grafts in both groups depending on the number of distal anastomoses. Hospital mortality was 2 patients (2.2%), both from group 2 (p = 0.161). The groups were comparable in the number of distal anastomoses (2.7 ± 0.7 and 2.7 ± 0.6, p = 0.532), the incidence of acute perioperative myocardial infarction (1 (1.1%) and 1 (1.1%), p = 0.987), neurological complications (1 (1.1%) and 2 (2.2%), p = 0.576), and bleeding requiring resternotomy (1 (1.1%) and 3 (3.3%), p = 0.325). Deep sternal wood infection was absent in both groups.

Conclusion. Autoarterial coronary artery bypass grafting is an effective method of myocardial revascularization in both the beating heart surgery and in cardiopulmonary bypass conditions. This method should be considered an operation of choice for patients with multiple coronary artery disease. The performance of operations in the conditions of cardiopulmonary bypass does not affect the increase in the number of cardiocerebral events in the postoperative period.
Role of magnetic resonance imaging and dual-energy computed tomography in diagnosis of adult heart rhabdomyoma: A clinical case
Authors: Mershina E. A. , Filatova D. A. , Sinitsyn V. E. , Lisitskaya M. V. , Dzemeshkevich S. L. , Zaklyazminskaya E. V. , Nechayenko M. A.
Published: April 2022

This article describes a clinical case of the heart rhabdomyoma in an adult patient diagnosed in early childhood. The result of the continued tumor growth was cardiac arrhythmia in the form of ventricular extrasystole with runs of ventricular tachycardia. Authors also present a literature review on the frequency of occurrence, morphology, clinical manifestations, and diagnosis of this type of heart tumors, including using dual-energy computed tomography and cardiac magnetic resonance imaging with intravenous contrast enhancement.