bluuebunny/crossref_metadata_2025 huggingface dataset:
Gastrointestinal manifestations in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) patient: major effect on treatment and prognosis
Authors: Ach Taieb , Hadami Ben Yamna , Ghariani Nadia , Said ElMabrouk Randa , Ben Abdelkrim Asma , Kacem Maha , Denguezli Mohamed , Ach Koussay
Published: April 2023

Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a rare autosomal recessive inherited syndrome caused by mutations in autoimmune regulator (AIRE) gene. The three clinical components of this syndrome are mucocutaneous candidiasis, hypoparathyroidism, and primary adrenal insufficiency. In addition to these frequent symptoms, many other components have been reported including gastrointestinal manifestations.We report a case of a 17-year-old Caucasian female patient diagnosed with APECED who presented with acute abdominal pain. Her medical history revealed chronic digestive discomfort without bowel movement disorders. The patient needed a significant increase in doses of calcium supplementation and hydrocortisone which appeared to be partially inefficient. Investigation with esophagogastroduodenoscopy and biopsy showed autoimmune atrophic gastritis. The patient eventually needed increasing doses of treatment received in order to achieve desired clinical and biological therapeutic goals.

Learning points

Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a rare autosomal recessive inherited syndrome caused by mutations in the autoimmune regulator (AIRE) gene.

The three clinical components of this syndrome that appear in early childhood are mucocutaneous candidiasis, hypoparathyroidism, and primary adrenal insufficiency.

In addition to these frequent symptoms, many other components have been reported including gastrointestinal manifestations like atrophic gastritis. They can be caused by many abnormalities including atrophic gastritis and the modification of intestinal biofilm and microbiota.

Early diagnosis and treatment of gastrointestinal manifestations associated with APECED prevent multiple life-threatening consequences like acute adrenal crisis and severe symptomatic hypocalcemia.
A rare case of isolated IgG4-related hypophysitis with Rathke’s cleft cyst presenting as panhypopituitarism
Authors: Hashmi Hiba Z , Rupakula Dinkar , Magar Rekha , Clark H Brent , Moheet Amir
Published: April 2023

We report a rare case of biopsy-proven isolated immunoglobulin G4 (IgG4)-related hypophysitis and Rathke’s cleft cyst (RCC) presenting as panhypopituitarism. A 54-year-old Caucasian female presented with symptoms of slurred speech, altered mental status, polyuria and polydipsia and was found to have panhypopituitarism. Brain MRI showed a suprasellar mass with suspected intralesional hemorrhage. She underwent trans-sphenoidal resection due to MRI evidence of compression of the optic chiasm and left optic nerve. Preoperatively, she was started on hydrocortisone, levothyroxine and desmopressin. Histopathology demonstrated a RCC with adjacent lymphoplasmacytic hypophysitis with numerous IgG4-immunoreactive plasma cells. Hydrocortisone was stopped at 10 months after confirming hypothalamic-pituitary-adrenal (HPA)-axis recovery and desmopressin was stopped at 1 year. There was recurrence of a cystic mass at 1 year follow-up. Over 4 years of follow-up, she continued to require levothyroxine, and the mass remained stable in size. In order to begin to understand how this case’s unique histopathological presentation influences clinical presentation, pituitary imaging and prognosis, we present an accompanying literature review.

Learning points

Isolated IgG4 hypophysitis and coexisting Rathke’s cleft cyst is a rare condition, which presents a diagnostic challenge.

Recognizing its characteristic features can assist with early recognition and initiation of therapy to promote optimal outcomes.

Further studies investigating the mechanisms promoting co-occurrence of these entities and their effect on prognosis are needed.
The World Health Organization classifications of pituitary neuroendocrine tumours: a clinico-pathological appraisal
Authors: Villa Chiara , Baussart Bertrand , Assié Guillaume , Raverot Gerald , Roncaroli Federico
Published: April 2023

The classification of tumours of the pituitary gland has recently been revised in the 2021 5th edition World Health Organization (WHO) Classification of Central Nervous System Tumours (CNS5) and 2022 5th edition WHO Classification of Endocrine and Neuroendocrine Tumours (ENDO5). This brief review aims to appraise the most relevant changes and updates introduced in the two classifications. A new nomenclature has been introduced in CNS5 and ENDO5 to align adenohypophyseal tumours with the classification framework of neuroendocrine neoplasia. The term pituitary neuroendocrine tumour (PitNET) with subtype information has therefore been adopted and preferred to adenoma. Pituitary carcinoma has been replaced by metastatic PitNET. The ICD-O coding has been changed from benign to malignant in line with NETs from other organs. Histological typing and subtyping based on immunohistochemistry for lineage-restricted pituitary transcription factors are regarded as the cornerstone for accurate classification. Such an approach does not fully reflect the complexity and dynamics of pituitary tumorigenesis and the variability of transcription factors expression. ENDO5 does not support a grading and/or staging system and argues that histological typing and subtyping are more robust than proliferation rate and invasiveness to stratify tumours with low or high risk of recurrence. However, the prognostic and predictive relevance of histotype is not fully validated. Recent studies suggest the existence of clinically relevant molecular subgroups and emphasize the need for a standardized, histo-molecular integrated approach to the diagnosis of PitNETs to further our understanding of their biology and overcome the unsolved issue of grading and/or staging system.
Non-pituitary GH regulation of the tissue microenvironment
Authors: Chesnokova Vera , Melmed Shlomo
Published: April 2023

Non-pituitary growth hormone (npGH) expression is well established in extrapituitary tissues, but an understanding of the physiological role of npGH remains rather limited. Pro-tumorigenic npGH impacting the tumor microenvironment has been reviewed. We focus here on autocrine/paracrine npGH effects in non-tumorous tissues and discuss its mechanisms of action in the normal tissue microenvironment. We address the tissue-specific effects of npGH in regulating stem, endothelial, immune, and epithelial cells and highlight the related role of npGH-associated changes in tissue aging.
Governing Defense Procurement: Strengthening the EU’s Defense Technological & Industrial Base
Authors: Vandercruysse Laurens , Du Bois Cind , Buts Caroline
Published: April 2023

The regulatory framework concerning defense procurement has evolved considerably since the start of the millennium. In addition to the general Public Procurement Directive and the Defense Procurement Directive, the European Commission recently formulated a proposal for a Foreign Subsidies Regulation (FSR). Nonetheless, defense sector particularities continue to produce tensions in public procurement, and significant blind spots remain.In view of policy objectives to strengthen the European Defense Technological & Industrial Base (EDTIB), it is necessary to first study the current state of EU defense procurement. To that end, we perform an analysis of 14,207 EU27-tenders spanning the period 2009-2020. In addition, a case study approach investigates six tender procedures by the Belgian military, establishing material points of note.Key insights include: (1) the number of defense procurement procedures won by third country bidders is limited, (2) tenders won by non-EU27-tenderers are larger and less competitive on average, and (3) an overly strong focus on price efficiency in public procurement award procedures inhibits attaining EDTIB goals. In short, the data shows a chasm between stated policy aims of strengthening the EDTIB through positive action in public procurement, on the one hand, and public procurement practices, on the other.
The future of the European defense firm
Authors: Hartley Keith
Published: April 2023

The future European defense firm will be radically different, being determined by future threats, novel technology, and yet to come European defense policy. The immediate threat arises from the war in Ukraine, but longer-term European defense policy based on the Strategic Compass will provide the framework for the future European defense firm. Past developments offer some indication of the future and it is predicted that the defense firm has a future and will survive. The past trend of smaller numbers of larger defense firms will continue with firms being even more technologically-intensive—reflecting Augustine weapons systems, which are characterized by continuously rising unit costs and smaller volumes. There will be more mergers between European defense firms and more joint European projects developing and producing combat air and naval systems, tanks, and cyber systems.
CS1: Intrinsic Motivation, Self-Efficacy, and Effort
Authors: Lakanen Antti-Jussi , Isomöttönen Ville
Published: April 2023

This research investigates university students’ success in their first programming course (CS1) in relation to their motivation, mathematical ability, programming self-efficacy, and initial goal setting. To our knowledge, these constructs have not been measured in a single study before in the Finnish context. The selection of the constructs is in line with the statistical model that predicts student performance (“PreSS”) (Quille and Bergin, 2018). The constructs are compared with various demographic and background variables, such as study major, prior programming experience, and average weekly working hours. Some of the main results of this study are as follows: (1) students generally entered with a high interest in programming and high motivation, but these factors did not increase during the course, i.e., interest in programming did not increase. (2) Having prior experience yielded higher initial programming self-efficacy, grade expectations, and spending less time on tasks, but not better grades (although worse neither). While these results can be seen as preliminary (and alarming in some parts), they give rise to future research for investigating possible expectation–performance gaps in CS1 and later CS studies. As our dataset accumulates, we also hope to be able to construct a valid success prediction model.
To Schedule or not to Schedule: The Effects of Course Structure on Programming MOOC Performance
Authors: Kaila Erkki , Lemström Kjell
Published: April 2023

Massive Open Online Courses (MOOCs) have become hugely popular recently. MOOCs can offer high-quality education for anyone interested and equalize the whole education field. Still, there are different methodologies for running MOOCs. Coming up with the most suitable methodology benefits both students and teachers. In this study, we have limited the methodological focus to observing scheduled and unscheduled instances of similar MOOC courses. While unscheduled MOOC courses can provide flexibility, they also require self-regulated learning strategies for students to succeed. To observe this, we compare the effectiveness of scheduled and unscheduled programming MOOC courses to find the most effective methodology. For this, we compare the pass rates and grade averages of five instances (two unscheduled and three scheduled) of Python and Java programming MOOCs. The results show that while the attendance numbers are higher in the unscheduled versions, in the scheduled instances the pass rate is significantly better, and students’ progression is much swifter. It also seems that the higher proportion of university students enrolled in a MOOC course positively affects the retention rate. Moreover, the students in the recent unscheduled Python version seem to score significantly higher grades than in its scheduled counterpart. Based on our experiments, the scheduled and unscheduled versions complement each other. Hence, we suggest that, whenever feasible, the maximal benefits would be gained if both types of MOOCs are run simultaneously.
Analysis of Youth Empowerment in Municipalities of Lithuania
Authors: Šukvietienė Aušra , Šilalienė Ilona
Published: April 2023

An empowerment in the scientific literature is usually understood as the share of the power with civil society or its groups and/or creation of conditions for them to participate in governance processes with equal rights, in order to ensure the democratic governance that meets the needs of citizens. This article analyzes the situation of youth empowerment at the municipal level in Lithuania, highlighting the conditions for their involvement and the arising challenges since youth policy in Lithuania is implemented in accordance with the principles of subsidiarity.Seeking to reveal the problematic of the topic and to review previous studies, an analysis of scientific literature was carried out, and also, the analysis of secondary statistical data was carried out based on youth empowerment evaluation criteria set out in the Evaluation Methodology of the Implementation of the Youth Policy. Main issues at municipality level were identified by performing a qualitative study (structure interview) with the Coordinators of youth affairs of selected municipalities, responsible for the implementation of youth policy and representatives of youth non-governmental organizations in these municipalities. The conducted research allowed identifying further necessary improvements for youth empowerment at municipality level and measures that would contribute to creating more favourable conditions for youth participation.
Kediripedia Online Media Editor's Strategy For Increasing Generation Z's Reading Interest
Authors: Hakim Lukman , Febriyanti Yani , Nur Fitriyah Siti Ayu , Meieka Nonik
Published: April 2023

Generation Z was born when digital technology was developing rapidly. They learned quickly and grew into a generation adept at using digital devices such as laptops, smartphones, tablets, and others. As a result, Generation Z spend more time using digital devices, exploring the virtual world, and interacting on social media than interacting face-to-face in real life. This behavior also arises because most of their daily activities are close to gadgets, so it becomes a new habit and impacts the decline in interest in reading. For this reason, means and ways are needed to change these habits. This research aims to find Kediripedia.com's strategy to generate interest in reading among Gen Z. The findings show that Kediripedia.com generate a strategy to increase young readers' interest in reading by taking two approaches. First, Kediripedia.com researched Gen Z to find out what kind of content and information presentation criteria interest them. Second, Kediripedia.com uses multi-platform information presentation by combining text, images, videos, and attractive visual design to create a playful yet accurate and credible information package for all groups, especially Generation Z.
Protecting Children and Adolescents From Tobacco and Nicotine
Authors: Jenssen Brian P. , Walley Susan C. , Boykan Rachel , Little Caldwell Alice , Camenga Deepa ,   SECTION ON NICOTINE AND TOBACCO PREVENTION AND TREATMENT, Groner Judith A. , Marbin Jyothi N. , Mih Bryan , Rabinow Lily , Blake Gregory H. , Smith Karen S. , Baumberger James D. ,   COMMITTEE ON SUBSTANCE USE AND PREVENTION, Gonzalez Lucien , Agarwal Rita , Quigley Joanna , Zoucha Kenneth , Kurien Christine , Ba’Gah Rebecca , Jarrett Renee
Published: April 2023

Tobacco use remains the leading preventable cause of disease and death for adults in the United States. Significant strides have been made in reducing rates of cigarette smoking among adolescents in the United States. However, rates of e-cigarette and similar device use among youth are high, and rates of other tobacco product use, such as cigars and hookahs, have not declined. Public policy actions to protect children and adolescents from tobacco and nicotine use, as well as tobacco smoke and aerosol exposure, have proven effective in reducing harm. Effective public health approaches need to be both extended to include e-cigarettes, similar devices, and other and emerging tobacco products and expanded to reduce the toll that the tobacco epidemic takes on children and adolescents.
Protecting Children and Adolescents From Tobacco and Nicotine
Authors: Jenssen Brian P. , Walley Susan C. , Boykan Rachel , Little Caldwell Alice , Camenga Deepa ,   SECTION ON NICOTINE AND TOBACCO PREVENTION AND TREATMENT, COMMITTEE ON SUBSTANCE USE AND PREVENTION, Groner Judith A. , Marbin Jyothi N. , Mih Bryan , Rabinow Lily , Blake Gregory H. , Smith Karen S. , Baumberger James D. ,   SECTION ON NICOTINE AND TOBACCO PREVENTION AND TREATMENT, COMMITTEE ON SUBSTANCE USE AND PREVENTION, Gonzalez Lucien , Agarwal Rita , Quigley Joanna , Zoucha Kenneth , Walker-Harding Leslie , Kurien Christine , Ba’Gah Rebecca , Jarrett Renee
Published: April 2023

This technical report provides the evidence base for the accompanying tobacco clinical report and policy statement. It builds on, strengthens, and expands AAP recommendations from the previous version in 2015. Tobacco use remains the leading preventable cause of disease and death for adults in the United States. The tobacco epidemic takes a substantial toll on children’s and adolescent’s health, including harms because of prenatal exposure during pregnancy, secondhand and thirdhand exposure during infancy and childhood, and/or direct use during adolescence. Tobacco and nicotine use almost always starts in childhood or adolescence. Almost 40% of children aged 3 to 11 years are regularly exposed to secondhand tobacco smoke, and rates of secondhand exposure to e-cigarette aerosol have increased over the last decade.
A Systematic Mapping Study on Process Improvement in Software Requirements Engineering
Authors: Almeida Silvia , Dávila Abraham
Published: April 2023

Software analysis is the process carried out to obtain requirements that reflects the needs of a client's stakeholders and that allows the construction of a software product that meets their expectations. However, it is also known as a process where many defects are injected. In this context, although process improvement has contributed to the software industry, in the case of software requirements it needs to be studied to determine the improvements obtained and established models. In the literature reviewed, a similar mapping study with 4 research question was identified and used as a reference. The objective of this work is to structure the available literature on process improvement in the software requirements engineering (SRE) domain to identify the improvement phases, paradigms, principles, and established models. For this purpose, a systematic mapping study (SMS) was carried out in the most recognized digital databases. The mapping carried out recovered a total of 1,495 studies, and after the process, 86 primary studies were obtained. In this SMS had established and answered 13 research questions. The different models that are applied throughout the software requirements engineering process were identified, and accepted studies were classified and findings on SRE process improvement were collected. The most used models are CMMI, Requirements Engineering Good Practice Guide (REGPG), and ISO/IEC 15504. Also, 62% of accepted studies are of the proposal and evaluation type; that is, they propose a framework and study the implementation of a proposal in one or more case studies respectively. On the other hand, it was found that most of the studies focused on the process improvement analysis phase. Likewise, in contrast with a previous study, proposal and validation type of studies increased in 9 papers each one from 2014 to date. This shows the interest of the scientific community in this domain.
Microservice Deployment
Authors: Niño-Martínez Victor M. , Ocharán-Hernández Jorge Octavio , Limón Xavier , Pérez-Arriaga Juan Carlos
Published: April 2023

Modern software development requires agile methods to deploy and scale increasingly demanded distributed systems. Practitioners have adopted the microservices architecture to cope with the challenges posed by modern software demands. However, the adoption and deployment of this architecture also creates technical and organizational challenges, potentially slowing down the development and operation teams, which require more time and effort to implement a quality deployment process that allows them to constantly release new features to production. The adoption of a DevOps culture, along with its practices and tools, alleviates some of these new challenges. In this paper we propose a guide for the deployment of systems with a microservices architecture, considering the practices of a DevOps culture, providing practitioners with a base path to start implementing the necessary platform for this architecture. We conducted this work following the Design Science Research Methodology for Information Systems (DSRM). In this way, we identified the problem, and also defined the solution objectives through the execution of a Systematic Literature Mapping and a Gray Literature Review, having as a result the proposed guide. This work can be summarized as follows: (I) Identification of practices and technologies that support the deployment of microservices. (II) Identification of recommendations, challenges, and best practices for the deployment process. (III) Modeling of the microservices deployment process using SPEM. (IV) Integration of the knowledge in a guide to deploy microservices by adopting DevOps practices.
Pengembangan Sistem Informasi Kredit Rumah Pegawai Pada Balai Pengelolaan Das Agam Kuantan Padang
Authors: Sy Yulia Jihan , Kurnia Rahmi Putri , Novi Novi
Published: April 2023

After conducting directly research into the Balai Pengelolaan DAS Kuantan Agam to find out the problems being faced by observations and interviews (interviews) with interested parties, it was found that data in the processing of home loan system was still manually. Processing data uses Microsoft Office Excel by input data to the tables and using formulas in Excel. This is find the problems about processing data. The problem that find double data in the management data. The information have a long time for processing data. The solve for this problem is development of housing credit data management. Development is make a program that uses a database to data storage and data processing to quickly and precisely. So the report will be faster, precise and accurate. For running this system have a very adequate device. The methodology in this research is field research, library research and laboratory research.
Modification of gelatin from tuna skins by green tea polyphenols
Authors: Chau Thanh Hien  , Dang Minh Nhat  , Mac Thi Ha Thanh
Published: April 2023

This paper presents the result of study on the effect of modifying conditions on properties and structure of tuna skin gelatin by using green tea polyphenols. The results showed that gelatin modified by green tea polyphenols changed its gel strength, degree of cross-linking, molecular weight and gel structure. The appropriate parameters to modify gelatin by using green tea polyphenols which indicated the best mechanical properties were determined as follows: temperature of 40oC in 40 minutes, polyphenol content of 20 mg/g gelatin and gelatin solution of 20%. As a result, modified gelatin showed a decrease in solubility, an increase in cross-linking degree (16.7%), molecular weight (55÷72 kDa) as well as a larger protein structure in comparison with the natural gelatin. The IR spectrograph of the modified gelatin did not show any evidence of forming new functional groups, only an apparent change in the absorption of infrared spectroscopy at the peak of the amide B region was found. The dried modified gelatin became insoluble in hot water.
Social and environmental impacts of traditional charcoal production: a case study in Hau Giang province, Viet Nam
Authors: Huynh Van Thao , Huynh Cong Khanh  , Nguyen Cong Thuan  , Nguyen Duc Tai  , Nguyen Van Cong
Published: April 2023

This study investigated the status, environmental health risks and assessed contaminant concentrations of waste gases and ambient air quality in traditional charcoal production kiln areas in Hau Giang province. In total, 284 charcoal producers, 160 charcoal workers and 160 neighbors were interviewed using structured questionnaires. Additionally, Carbon monoxide (CO), nitro dioxide (NO2), total suspended particles (TSP), and sulfur dioxide (SO2) from traditional kilns and ambient air samples were analyzed. The result show that the number of kilns owned by each charcoal producer was 3.13 kilns per household; of which the average volume of each kiln was 59.07­ m3 kiln-1, with a yearling charcoal yield of around 80.71 ton kiln-1. The profitability of charcoal producers was annually approximately 133 million VND per household. Charcoal workers predominantly reported suffering from eye irritation issues (41.6%) whilst adjacent neighbors frequently experienced respiratory problems (87.5%). The interviewees obviously recognized the negative impacts of charcoal production activities on community health (63.1% respondents) and local fruit farmers (79.4% respondents), yet only the minority of residents (8.11% respondents) required a change from the current charcoal-based livelihood. The CO, TSP, and SO2 in waste gas compositions all exceeded the maximum permissive levels of the Vietnamese National Standard (QCVN 19:2009/BTNMT), while the air quality surpassed the safety level of TSP and SO2 (QCVN 05:2013/BTNMT). This indicates very high risk to those who are regularly exposed to the air pollutants. The study suggested that technological solutions and responsible policies should be enforced to promote the sustainability of charcoal production and minimize the negative impacts on human health and the environment.
The size-and shape-controlled synthesis of silver nanoparticles by solvothermal method
Authors: Nguyen Thi Ngoc Linh  , Le The Tam  , Ngo Thanh Dung  , Le Thi Thanh Tam  , Ha Minh Nguyet  , Nguyen Dinh Vinh  , Bui Minh Quy  , Nguyen Thi Hong Hoa  , Nguyen Hoa Du  , Le Trong Lu  , Nguyen Trung Thanh
Published: April 2023

In this work, Ag nanoparticles (NPs) were fabricated by thermal decomposition of silver nitrate in organic solvents in the presence of sodium oleate (SOA) and 1-octadecanol (OCD-ol). The effects of different solvents and concentrations of OCD-ol on the morphology and properties of the Ag nanomaterials were investigated in detail. The structural analysis of the Ag nanomaterials showed good crystallinity. The TEM images of the samples showed that with the change in the fabrication conditions, different sizes and shapes of Ag nanomaterials were formed. The surface plasmon resonance (SPR) properties of the  Ag NPs were influenced by their size and shape. The as-synthesized Ag NPs have potential applications in biomedical, catalysis, or electronics.
Potential use of residues from thermal conversion processes for CO2 capture
Authors: Phuong Nguyen Thu , Nguyen Hong Nam , Dao Thanh Duong  , Trinh Bich Ngoc  , Le Phuong Thu  , Dinh Thi Mai Thanh  , Nguyen Van Dong
Published: April 2023

Economic development in many developing countries is leading to a significant increase in atmospheric CO2 in recent decades, exacerbating global climate change. One of the solutions being vigorously researched is the use of cheap and environmentally friendly CO2 adsorbents. In this study, solid residues from gasification of bagasse, and pyrolysis of macadamia nut shells were used for CO2 adsorption. The N2 adsorption/desorption results showed that the post-gasification residue was much more porous compared to the post-pyrolysis residue. The CO2 adsorption experiments were carried out in laboratory conditions (100 % CO2, 25 °C) and flue gas conditions (15 % CO2, 40 °C). The bagasse residue achieved a high and stable CO2 adsorption value at 2.3 mmol/g, 2.5 times more than that of macadamia nut shells residue. This result showed that residues from thermal conversion processes could be re-used as cheap and environmentally friendly materials for CO2 capture.
Boas práticas, intervenções e resultados: um estudo comparativo entre uma casa de parto e hospitais do Sistema Único de Saúde da Região Sudeste, Brasil
Authors: Medina Edymara Tatagiba , Mouta Ricardo José Oliveira , Carmo Cleber Nascimento do , Filha Mariza Miranda Theme , Leal Maria do Carmo , Gama Silvana Granado Nogueira da
Published: April 2023

O objetivo deste estudo foi comparar a assistência obstétrica em uma casa de parto e em hospitais do Sistema Único de Saúde (SUS) da Região Sudeste do Brasil, considerando boas práticas, intervenções e resultados maternos e perinatais. Realizou-se um estudo transversal com dados retrospectivos comparáveis, provenientes de dois estudos sobre parto e nascimento, e amostra de 1.515 puérperas de risco habitual de uma casa de parto e hospitais públicos da Região Sudeste. Utilizou-se ponderação pelo escore de propensão para equilibrar os grupos de acordo com as covariáveis idade, raça, paridade, integridade das membranas e dilatação do colo na internação, bem como regressões logísticas para estimar razões de chance (OR) e intervalos de 95% de confiança (IC95%) entre o local de parto e desfechos. Na casa de parto, quando comparada ao hospital, as puérperas tiveram maior chance de ter acompanhante (OR = 86,31; IC95%: 29,65-251,29), se alimentar ou tomar líquidos (OR = 862,38; IC95%: 120,20-6.187,33), se movimentar (OR = 7,56; IC95%: 4,65-12,31), usar métodos não farmacológicos para alívio da dor (OR = 27,82; IC95%: 17,05-45,40) e posição verticalizada (OR = 252,78; IC95%: 150,60-423,33) e menor chance de utilizar ocitocina (OR = 0,22; IC95%: 0,16-0,31), amniotomia (OR = 0,01; IC95%: 0,01-0,04), episiotomia (OR = 0,01; IC95%: 0,00-0,02) e manobra de Kristeller (OR = 0,01; IC95%: 0,00-0,02). Ademais, na casa de parto os recém-nascidos tiveram maior chance de aleitamento exclusivo (OR = 1,84; IC95%: 1,16-2,90) e menor chance de aspiração de vias aéreas (OR = 0,24; IC95%: 0,18-0,33) e gástrica (OR = 0,15; IC95%: 0,10-0,22). A casa de parto apresenta, assim, maior oferta de boas práticas e menos intervenções na assistência ao parto e nascimento, com segurança e cuidado, sem afetar os resultados.
People development in startups
Authors: Melenchion Jose Ricardo , Kubo Edson K. M. , Oliva Eduardo C. , Cohen Eric David
Published: April 2023

Abstract Purpose: This article aims to analyze how the practices related to the development of people in startups are configured. Originality/value: Considering that, until then, studies referring to startups focused on their concept, characteristics, and key success factors, this research contributes to filling a gap in the theory, as it presents a people development model suited to the characteristics of startups and, in this way, it makes possible to the founders or managers of startups to use the findings of this research in order to improve their performance. Design/methodology/approach: The methodological aspects of this research are characterized by exploratory and qualitative research. Semi-structured interviews are used as a collection technique in 16 startups. Findings: We observed that in startups: Teamwork is prioritized, the work environment is informal, the development of competencies occurs in the work environment itself through self-development or training provided by specialized professionals or by the leadership, there is flexibility in the time, place, manner in which activities are carried out, and the employee may even act in activities that would not be the responsibility of the position held.
Mudança do regime de proteção das Áreas de Preservação Permanentes no código florestal de 2012
Authors: Chaves Liane Amelia , Neves Sandra Mara Alves da Silva , Pierangeli Maria Aparecida Pereira , Castrillon Solange Kimie Ikeda , Kreitlow Jesã Pereira
Published: April 2023

Resumo O parâmetro para delimitação das Áreas de Preservação Permanentes (APPs) do Código Florestal de 2012 é a borda da calha do leito regular do curso d’água e não o seu nível mais alto. O objetivo deste estudo é avaliar a perda de áreas protegidas, enquadradas na categoria das APPs hídricas, em virtude do Código Florestal de 2012, no rio Cabaçal, MT Por meio das tecnologias espaciais, foram elaborados mapas de cobertura vegetal e uso da terra de 2012 e 2018. A mudança do Código Florestal em 2012 ocasionou perda de 90% de área anteriormente protegida pelo de 1965, correspondente ao leito maior hidrológico do rio Cabaçal, especialmente no baixo curso, situado na planície do Pantanal mato-grossense. Concluiu-se que a cobertura vegetal nas Áreas de Preservação Permanente foi suprimida para que os usos urbano e agropecuário fossem implantados, caracterizando-as como de conflitos devido à flexibilização da legislação ambiental.
Environmental education trends and concepts of actions registered in SisEA/MS and carried out in Ladário/MS
Authors: Vieira Maria Rita Mendonça , Zanon Angela Maria
Published: April 2023

Abstract This investigation seeks to analyze the concepts of Environmental Education (EE) in the proposals registered in the State System of Information on Environmental Education of Mato Grosso do Sul (SisEA/MS), carried out in the municipality of Ladário, State of Mato Grosso do Sul, Brazil. The research with a quantitative-qualitative approach deals with the document analysis of 27 proposals. The quantitative nature involved the evaluation of indicators: status of proposals, type of action, themes and target audience. The qualitative approach was given by the Discourse Analysis (DA), evidencing the conceptions in EE. The conservative aspect was predominant in the actions, with a view to a behavioral change of the individual, disregarding the socio-political dimension. The inferences brought here show ways to overcome practices that follow conservative trends in EE, in the search for practices that seek to transform reality. It is necessary to (re)think the methodological procedures of the actions, considering the theoretical foundations, themes and target audience for a critical and transformative EE.
A PERCEPÇÃO SOCIOECONÔMICA DOS ATINGIDOS PELAS USINAS HIDRELÉTRICAS DO RIO ARAGUARI/AP, AMAZÔNIA ORIENTAL
Authors: Carvalho Thais Pantoja de , Malcher Jorge Angelo Simões , Brito Daguinete Maria Chaves
Published: April 2023

Resumo A implantação de uma hidrelétrica comumente envolve conflitos, entre os povos tradicionais e os empreendimentos hidrelétricos. O objetivo da pesquisa foi analisar as percepções dos moradores da sede municipal de Ferreira Gomes sobre os impactos sociais e econômicos de três hidrelétricas (Coaracy Nunes, Ferreira Gomes e Cachoeira Caldeirão) instaladas no rio Araguari, Amapá. Os dados foram obtidos mediante aplicação de formulário semiestruturado, cujo tamanho da amostra foi calculado usando o ‘Teorema do Limite Central’, que posteriormente foram tabulados em planilhas eletrônicas e analisados. A pesquisa revelou que as hidrelétricas estabeleceram novas dinâmicas sociais e econômicas no cotidiano da população atingida, em sua maioria de forma negativa e afetaram direta e indiretamente a qualidade de vida, saúde, renda, custo de vida e segurança da população local.
THE SOCIOENVIRONMENTAL PERCEPTION OF THE ONES AFFECTED BY THE HYDROELECTRIC POWER PLANTS ALONG THE ARAGUARI RIVER/AP, EASTERN AMAZON
Authors: Carvalho Thais Pantoja de , Malcher Jorge Angelo Simões , Brito Daguinete Maria Chaves
Published: April 2023

Abstract The establishment of a hydroelectric power plant commonly involves conflict between the local traditional people and the hydroelectric enterprises. The research aims to analyse the perceptions of residents of the municipality of Ferreira Gomes about the social and economic impacts of three hydroelectric dams (Coaracy Nunes, Ferreira Gomes and Cachoeira Caldeirão) installed on the Araguari River, Amapá. The data was obtained through submitting the locals to a semi-structured form, whose sample was calculated utilizing the “Central Limit Theorem’, which later was charted and analysed. The research has shown that the dams established new social and economic dynamics in the affected populace’s daily life, mostly negative ones, which hit directly and indirectly the quality of life, health, income, cost of living and security of the local people.
GUIDELINES FOR PLANNING AND DESIGNING PAYMENT FOR ENVIRONMENTAL SERVICES SCHEMES
Authors: Guerra Bartira Rodrigues , Ranieri Victor Eduardo Lima
Published: April 2023

Abstract Payment for Environmental Services (PES) is an economic instrument that aims to reconcile the conservation of ecosystem services (ES) with the economic interests of the actors involved. In order to guide decision-makers in the process of structuring and planning PES schemes, this article analyzed Brazilian schemes against the best practices recommended in the scientific literature. As a result, monitoring the ES provision or its proxies and spatial segmentation were practices observed in Brazilian schemes in line with literature recommendations. The same did not happen with practices: flexible and/or adaptable contracts and payments greater than provision costs. These results are useful to reinforce strengths and point out possible vulnerabilities in the design of PES schemes, contributing to the improvement of both new and ongoing initiatives.
Efeito da sazonalidade sobre as respostas fisiológicas e produtivas de vacas leiteiras mestiças ao clima amazônico equatorial
Authors: Costa Dayana Alves da , Santos Vinícius Moreira dos , Oliveira Antônia Valcemira Domingos de , Souza Clebson Lucas de , Moreira Guilherme Rocha , Rosa Bruna Laurindo , Reis Eduardo Mitke Brandão , Queiroz Adriano Melo de
Published: April 2023

Resumo O objetivo desse estudo foi avaliar os efeitos sazonais dos meses do ano sobre as respostas fisiológicas e produtivas de vacas leiteiras mestiças criadas em clima amazônico. Foram avaliadas 20 vacas lactantes, alimentadas com pasto de Brachiaria decumbens, com acesso livre a água e suplementação mineral. Foram registrados dados das variáveis climáticas temperatura do ar (TA), umidade relativa do ar (UR), precipitação pluviométrica (PP) e índice de temperatura e Umidade (ITU) durante os meses de janeiro a abril de 2019. Os dados fisiológicos coletados foram: frequência respiratória (FR, mov/min), frequência cardíaca (FC, bat./min), temperatura retal (TR, ºC), temperatura superficial do úbere (TSU, ºC), temperatura superfície corporal (TSC, ºC), temperatura superficial do dorso (TSD, ºC), temperatura superficial da fronte (TSF, ºC) e temperatura superficial da canela (TSCA, °C). Também foi mensurada a produção de leite (PL, kg). Houve diferença significativa (P<0,05) da TSCA e FR com valores variando de 34,8 a 35,5°C e 32,0 a 36,2 mov/min, respectivamente. Não houve diferença significativa (P>0,05) para TSC e os valores observados para PL e ITU foram 3,8; 3,8; 4,6; 4,1 kg e 77,7; 79,7; 80,6; 80,1, respectivamente. Houve efeito sazonal dos meses avaliados sobre a taxa respiratória dos animais, no entanto, isso não alterou a PL nem o ITU. O ambiente amazônico é propício a causar estresse térmico em vacas lactantes mantidas a pasto, sendo necessário o uso de sombreamento para facilitar a capacidade de dissipação de calor corporal desses animais.
Association of Kappa casein gene polymorphism with milk production traits in crossbred dairy cows
Authors: Albazi Wefak J. , Al-Thuwaini Tahreer M. , Alamely Muna , Jeddoa Zuhair MA. , Mousa Rana , Al-Dawmy Faten , Atallah Aqeel H. , Altaee Raeed , Jabber Eman , Al-Shimmary Fateh , Salin Saba , Al-Himaery Nabaa
Published: April 2023

Abstract Milk’s qualitative and technological properties are greatly affected by genetic polymorphisms in the kappa-casein gene, and their polymorphisms may serve as informative markers of yield and composition. Thus, the objective of this study was to detect kappa-casein (kappa-CN) gene polymorphisms and their association with milk production traits in crossbred dairy cows. One hundred healthy crossbred (Friesian x Jenoubi) dairy animals between three and five years old were sampled for blood and milk during their first lactation. The genomic DNA was extracted from whole blood, and restriction fragment length polymorphism (RFLP-PCR) was used to determine the genotype of the kappa-CN gene. As a consequence of the restriction digestion of this fragment with Hind III, it showed three different restriction patterns: BB (453 base pairs uncut), AB (453, 206, and 225 base pairs), and AA (206 and 225 base pairs). Based on genetic diversity, the AB genotype was the most predominant (n = 67), with a frequency of 0.67. A variant genotype of the kappa-CN gene was associated with milk production traits in crossbred dairy cows. Animals with the AA variant produced a higher milk yield and a higher percentage of fat, casein, protein, and solids not fat (SNF) (P≤0.05) (1.397kg, 0.75%, 0.31%, 0.27%, and 0.68%, respectively) than those with the BB variant. A logistic regression analysis confirmed that the kappa-CN genotypes increase milk yield and casein content. Therefore, genetic variants of the kappa-CN gene could be used as genetic markers for improving milk production traits in dairy cattle.
Percepção dos fonoaudiólogos sobre alterações miofuncionais orofaciais em sujeitos com Síndrome Congênita pelo Zika Vírus
Authors: Lopes Sobrinho Paulo Naati , Vasconcelos Manuela Leitão de , Martinelli Roberta Lopes de Castro , Pernambuco Leandro de Araújo , Alves Giorvan Ânderson dos Santos
Published: April 2023

RESUMO Objetivo: investigar o perfil e a percepção de fonoaudiólogos do Nordeste do Brasil, que atuam com crianças com Síndrome Congênita pelo Zika vírus, quanto aos aspectos miofuncionais orofaciais e aos procedimentos de intervenção fonoaudiológica. Métodos: trata-se de estudo transversal, observacional, com análise quanti-qualitativa. O instrumento de coleta de dados tratou-se de um questionárioon-line, que continha 34 questões abrangendo: dados sociodemográficos e questões voltadas para a percepção de fonoaudiólogos no que se refere ao assunto estudado. A amostra foi composta por 23 fonoaudiólogos dos nove estados do Nordeste. Resultados: da amostra, 96% foram mulheres. A maioria dos profissionais apresentava mais de 3 anos de experiência com a Síndrome Congênita pelo Zika Vírus. Na caracterização do sistema estomatognático, os profissionais descreveram maior grau de alteração nos aspectos de postura e mobilidade da musculatura orofacial. Em relação às funções, observou-se maior percepção de alteração na fala e deglutição para líquido e sólido. Conclusão: a maioria dos fonoaudiólogos da pesquisa possuem especialização, com destaque nas áreas de Disfagia e Motricidade Orofacial. Os profissionais afirmaram que a postura e mobilidade da musculatura orofacial são os aspectos mais alterados, assim como as funções de fala e deglutição de sólido e líquido.
Pre-germination treatments in pitaya (Hylocereus spp.) seeds for water stress mitigation
Authors: Carvalho Sara M. C. , Paiva Emanoela P. de , Torres Salvador B. , Souza Neta Maria L. de , Leite Moadir de S. , Sá Francisco V. da S.
Published: April 2023

ABSTRACT The use of mitigating agents to minimize the deleterious effects of water stress is a promising alternative for plant species, especially during germination and initial seedling development. Thus, the objective was to evaluate the effect of different pre-germination treatments as mitigating agents of water stress during germination and initial development of pitaya seedlings of the species Hylocereus undatus and H. costaricensis. The experiment was carried out in a completely randomized design, in a 2 x 6 factorial scheme, corresponding to two pitaya species and six pre-germination treatments (T1 = 0.0 MPa (control), T2 = -0.2 MPa (water stress); T3 = hydropriming + water stress; T4 = gibberellic acid + water stress; T5 = salicylic acid + water stress and T6 = thiamethoxan + water stress) with four replicates of 50 seeds. The variables analyzed were germination, germination speed index, shoot and primary root lengths, total dry mass, total soluble sugars and total free amino acids. The water potential of -0.2 MPa is limiting for germination and initial growth of H. costaricensis and H. undatus, with H. undatus being more tolerant to water stress in the germination phase. Pre-germination treatments with hydropriming, gibberellic acid, salicylic acid and thiamethoxan improve the physiological performance of H. costaricensis seeds, with gibberellic acid being the best attenuator of water stress. Gibberellic acid improves the physiological performance of H. undatus seeds under water deficit conditions.
Plot size and number of repetitions in forage wheat
Authors: Bubans Valéria E. , Cargnelutti Filho Alberto , Neu Ismael M. M. , Silveira Daniela L. , Somavilla Felipe M. , Osmari Bruno F.
Published: April 2023

ABSTRACT Forage wheat (Triticum aestivum L.) is an annual crop, alternative for use as a ground cover crop in the winter period, in production systems in southern Brazil. Given its magnitude, research with field experiments is carried out and plot size definition is of great importance in the experimental design. The objectives of this study were to estimate the plot size and number of repetitions to evaluate the fresh matter of forage wheat and to investigate the variability of plot size among agricultural years, sowing dates and cultivars. Thirty-six uniformity trials were conducted (two agricultural years × three sowing dates × two cultivars × three repetitions). Plot size was determined by the method of maximum curvature of the coefficient of variation model. The number of repetitions was determined for experiments in completely randomized and randomized block designs in scenarios formed by the combinations of i treatments (i=3, 4, …, 50) and d least significant differences among treatment means to be detected as significant by the Tukey test, at 5% of significance, expressed as a percentage of the overall mean of the experiment (d=5%, 10%, …, 30%). The plot size to evaluate the fresh matter of forage wheat is 4.05 m2. Seven repetitions are sufficient to identify the fresh matter in completely randomized designs and randomized block designs with up to 50 treatments, making it possible to obtain least significant difference lower than or equal to 20% of the mean of the experiment.
Aprendizagem Mediada por Dispositivos Móveis: um estudo sobre affordances com vistas ao desenvolvimento das tarefas de leitura em inglês
Authors: Santos Eduardo Simão dos , Braga Júnia de Carvalho Fidelis
Published: April 2023

Resumo Os dispositivos e aplicativos móveis estão presentes em diversas práticas sociais. Como eles estão também presentes nas práticas educacionais, faz-se necessário investigar suas possibilidades e limitações em contextos de aprendizagem de línguas no ensino superior. Este estudo, de natureza qualitativa interpretativista, tem o objetivo de investigar as affordances que surgem da utilização de dispositivos e aplicativos móveis no desenvolvimento de atividades de leitura em inglês. Para a geração dos dados, foi aplicado um questionário semiestruturado aos estudantes das disciplinas de Inglês Instrumental I e II, ofertadas pela Faculdade de Letras de uma instituição federal de ensino. Os resultados demonstram que, durante as atividades propostas nesses cursos, os estudantes se apropriam de dispositivos e aplicativos móveis para buscar significados de palavras – principalmente em pesquisas rápidas – respostas para dúvidas a qualquer hora e no próprio ritmo (otimização do tempo de estudo), bem como para aprimorar seu repertório lexical. O tamanho da tela dos smartphones e a usabilidade do Moodle para tarefas nesses dispositivos foram informadas como algumas das limitações para o desenvolvimento das tarefas propostas nos cursos. Esses resultados poderão servir de ponto de partida para futuras investigações sobre o uso dessas tecnologias digitais no contexto de aprendizagem de línguas.