bluuebunny/crossref_metadata_2025 huggingface dataset:
Improving access to palliative care for critically ill cancer patients in intensive care -A Quality Improvement initiative from a tertiary referral cancer centre in India.
Authors: BALAKRISHNAN KALPANA , .Ramasamy Thendral , Venketeswaran Meenakshi
Published: May 2022

Objectives/Background: Anaesthesiologists who were also working in palliative care (PC) wanted PC to be available for critically ill cancer patients in an exclusive oncology intensive care (ICU) with the aim of better communication and care giver comfort.Methods: A3 problem solving method with Plan Do check Act (PDCA) method of quality improvement was used. First a process map of patient movements into and out of ICU was made. Root cause assessment with the 5 whys were used to find the barriers for PC referral and included Lack of a protocol to assess PC needs, non-availability of PC data in intensive care electronic records and inadequate pathway for continuity of care after ICU discharge.Interventions: After consensus building, we introduced a PC referral trigger tool to initiate referral and ensured availability of list of PC centers for referral at discharge desk. Continued education of residents and nurses to use the tool helped in sustaining PC referral from ICU.Results/Outcomes: Patients continued access to PC both while in ICU and after discharge started increasing from baseline 0% to over 75% by mid-March 2020 .Conclusion: A structured QI process helped initiate access to PC for more than 50% of critically ill cancer patients.Lessons learned: Quality improvement process by its systematic methodology helps in attaining goals. Oncologists are not averse to initiation palliative care in ICU. However, for sustained results regular educational reinforcements of the support staff are needed.
Multiglandular Parathyroid Disease
Authors: Kowalski Grzegorz , Buła Grzegorz , Bednarczyk Adam , Gawrychowska Agata , Gawrychowski Jacek
Published: May 2022

BACKGROUND: Multiglandular parathyroid disease (MGD) is an uncommon cause of primary hyperparathyroidism (pHPT) and has been reported in the literature in 8–33 % of patients with pHPT. The aim of our study was to review the clinical characteristics and management of MGD and evaluation of surgical treatment failures.METHODS: We performed a retrospective study of 163 patients with pHPT undergoing parathyroidectomy (PTX) at the Department of General and Endocrine Surgery, between 1983 and 2018. All these patients were diagnosed with MGD. This group of patients was compared with the group of 856 patients with solitary disease operated for pHPT in the same period. RESULTS: Among 163 patients – 129 (79%) of them had two lesions, 26 (16%) had three and 8 (5%) four. They were prevalently women over the age of 50. The diagnosis was based on PTH and ionized calcium studies and used sestamibi technetium-99m scintigraphy (MIBI) scintigraphy as well for us. Treatment was surgical.CONCLUSIONS: Parathyroidectomy (PTX) for multiglandular parathyroid disease (MGD) is associated with a higher operative risk of failure compared to solitary disease. Preoperative diagnosis and localization of the parathyroid glands is an extremely important element of treatment. Mediastinal MGD is associated with increased surgical treatment failures.
Reconstruction of the medial patellofemoral ligament with autologous peroneal longus tendon versus semitendinosus tendon: a case control study
Authors: Han Mingzhan , Zhang Qianlong , Chen Wencao , Zhang Siping , Zhang Wenhao , Mou Limin , Yakufu Maihemuti , Liu Wei , Ma Pengcheng
Published: May 2022

Objective：In order to treat and improve recurrent patellar dislocation (RPD), autologous partial peroneal long tendon (PLT) or autologous partial semitendinosus tendon (ST) were taken to reconstruct the medial patellofemoral ligament (MPFL) respectively. The postoperative effects of the two methods were compared.Method:Patients with RPD in the Department of orthopedics of the Sixth Affiliated Hospital of Xinjiang Medical University were selected, and underwent MPFL reconstruction from February 2018 to February 2021. There were 65 cases, including 20 male patients and 45 female patients. The grafts were autologous PLT or ST, including 32 cases in PLT group and 33 cases in ST group. The evaluation indexes include: postoperative complications: patellar fracture, patellar subluxation, knee pain, knee stiffness, lower limb skin paresthesia, patellar tilt angle, patellar concentration angle, Kujala score and kofoed score of ankle. The functional improvement and complications of patella and knee joint before and after operation were compared, and the curative effect of PLT and ST reconstruction of MPFL was analyzed.Results：The follow-up time was 12-15 months. There were 7 cases of knee pain and 5 cases of knee stiffness in PLT group and 5 cases of knee pain and 3 cases of knee stiffness in ST group. There was no significant difference in postoperative pain and stiffness between the two groups (P > 0.05). There were 18 cases of infrapatellar branch of saphenous nerve (IPBSN) injury in ST group, but no IPBSN injury was found in PLT group (P < 0.05). The IPBSN injury in ST group was positively correlated with the incision length of tendon extraction (P < 0.05). In the last follow-up, there was no significant difference in patellar tilt angle, patellar convergence angle and Kujala score between the two groups (P > 0.05). The kofoed score of ankle joint in both groups was excellent.Conclusions：Autologous PLT and ST reconstruction of MPFL can effectively treat RPD, significantly improve patellar tilt angle and patellar concentration angle, improve Kujala score, improve knee function and clinical symptoms. Both are effective ways to treat RPD, but ST group will lead to IPBSN injury and sensory impairment of anterolateral skin of lower leg.
“We should be at the table together from the beginning”: sub-Saharan African perspectives on global health research partnerships
Authors: Voller Shirine , Chitalu Chama-Chiliba Miriam , Nyondo-Mipando Alinane Linda , Opobo Timothy , Bangirana Clare Ahabwe , Thorogood Nicki , Schellenberg Joanna , Chi Primus
Published: May 2022

Background: Global health research partnerships have been scrutinised for how they operate and criticised for perpetuating inequities. Guidance to inform fair partnership practice has proliferated and the movement to decolonise global health has added momentum for change. In light of this evolving context, in this study we sought to document contemporary experiences of partnership from the perspective of stakeholders in a sample of sub-Saharan African research institutions. Methods: We conducted qualitative interviews with 20 stakeholders at four research institutions in four countries in anglophone eastern and southern Africa. Interview questions were informed by published guidance on equitable research partnerships. Data was analysed through an iterative process of inductive and deductive coding, supported by NVivo software.Results: Early to mid-career and senior researchers and research administrators from four sub-Saharan African research institutions described wide-ranging experiences of partnership with high-income country collaborators. Existing guidelines for partnership provided good coverage of issues that participants described as being the key determinants of a healthy partnership, including mutual respect, role clarity and early involvement of all partners. However, there was almost no mention of guidelines being used to inform partnership practice. Participants considered the key benefits of partnership to be capacity strengthening and access to research funding. Meanwhile, participants continued to experience a range of well-documented inequities, including exclusion from agenda setting, study design, data analysis and authorship; and relationships that were exploitative and dominated by high-income country partners’ interests. Participants also reported emerging issues where their institution had been the prime recipient of funds. These included high-income country partners being unwilling to accept a subordinate role and failing to comply with reporting requirements. Conclusions: Contemporary global health research partnerships generate considerable benefits but continue to exhibit longstanding inequities and reveal emerging tensions. Long-term support targeted towards institutions and national research systems remains essential to fulfil the potential of research led from sub-Saharan Africa. High-income country stakeholders need to find new roles in partnerships and stakeholders from sub-Saharan Africa must continue to tackle challenges presented by the resource-constrained contexts in which they commonly operate.
Systemic lupus of pediatric onset: the experience of the French overseas departments of America
Authors: Felix Arthur , Delion Frederique , Suzon Benoit , Martin Elise , Ogrizek Anais , Sahnoun M'hamed Mohamed , Hospice Claudia , Armougon Aurelie , Cuadro Emma , Elenga Narcisse , Dramé Moustapha , Bader-Meunier Brigitte , Deligny Christophe , Hatchuel Yves
Published: May 2022

Introduction: Systemic diseases of pediatric onset are more frequent in the Afro-Caribbean population. We performed a study of patients followed in French overseas departments of America (FOAD) for pediatric systemic lupus (pSLE). The aims were to describe their clinical and biological specificities during childhood.Methods: A retrospective study was conducted between January 2000 and September 2021. Listings of patients with pediatric onset were obtained through multiple sources: computerized hospital archives, registry of referent pediatricians and adult specialists in internal medicine and French National Registry for rare diseases. The spectrum of diseases studied was systemic lupus according to international criteria with pediatric onset.Results: Overall, 2148 patients were identified, and 54 patients were included. The average follow-up was 8.3 years (range: 0.3 - 25 years). We found an increase in new diagnoses throughout the years. At onset, pSLE patients had a median of 10 SLICC criteria (range: 4-12), and the median EULAR/ACR 2019 score was 38 (12 - 54). At onset, one-third of patients had renal involvement, 15% neurolupus and 41% cardiac involvement. During childhood, 54% had renal involvement, and 26% suffered from neurolupus. Patients suffered a median of 3 flares during childhood and 26% from more than 5 flares. Younger patients at onset had worst outcomes; they had more flares (median at 5 p = 0,02) and needed an average of 4 background therapies (p = 0,04).Conclusion: The outcomes of Afro-Caribbean patients, where pSLE is more frequent, were similar to those in Western countries with worse disease activity at onset. Further studies should be performed to identify the genetic and environmental factors in this population.
MIS-C: Clinical profile, outcomes and predictors of severe disease
Authors: Subhash Swathy , Joji Prameela , Baby Greeshma , Nair Nisha , Kumar Shiju , Gupta Neetu
Published: May 2022

ObjectiveMIS-C is a novel disease entity. We aimed to outline the clinical features and laboratory parameters of children with moderate to severe MIS-C and to study predictors of more severe disease. MethodsIn this prospective longitudinal study, all children less than 15 years of age requiring admission to the Paediatric Intensive Care Unit (PICU) or High Dependency Unit (HDU) with three or more days of fever were screened for MIS-C according to the WHO case definition. Children with alternative diagnoses were excluded. Those included were tested for active or past infection with SARS-COV2 using RTPCR or antibody testing. Severe MIS-C was defined as presence of ventricular dysfunction, coronary dilatation, need for respiratory support, inotropes or invasive ventilation. Clinical features, laboratory parameters and risk factors for severe disease was studied.Results60 children were included in the study. Median age group was 5yrs(IQR 2.175,9)The median duration of PICU/HDU stay was 4 days(IQR 2,5.75). Two children died of the illness. Gastrointestinal symptoms were most common(73%) followed by muco-cutaneous(56%), respiratory(46%) and cardiovascular system(41%) involvement. Majority showed neutrophilia(73%), leucopenia(53%) and raised inflammatory markers including ESR,CRP, D-dimer, ferritin and NT-proBNP which showed significant association with need for respiratory support, inotropes, cardiac dysfunction and prolonged ICU stay. Gastrointestinal symptoms, respiratory distress, reduced urine output at admission, platelet counts less than 1.5 lakhs, D-dimer >2000ng/mL, CRP >70mg/L, NT-proBNP>500pg/mL, ferritin >250mcg/L were markers of severe MIS-C.ConclusionClinical features and laboratory parameters aid in early recognition of severe MIS-C resulting in greater probability of survival.
Hierarchical Reinforcement Learning for Efficient and Effective Automated Penetration Testing of Large Networks
Authors: Ghanem Mohamed Chahine , Chen Thomas , Nepomuceno Erivelton
Published: May 2022

Penetration testing (PT) is a method for assessing and evaluating the security of digital assets by planning, generating, and executing possible attacks that aim to discover and exploit vulnerabilities. In large networks, penetration testing becomes repetitive, complex and resource-consuming despite the use of automated tools.
This paper investigates reinforcement learning (RL) to make penetration testing more intelligent, targeted, and efficient. The proposed approach called Intelligent Automated Penetration Testing Framework (IAPTF) utilizes model-based RL to automate sequential decision making. Penetration testing tasks are treated as a partially observed Markov decision process (POMDP) which is solved with an external POMDP-solver using different algorithms to identify the most efficient options.
A major difficulty encountered was solving large POMDPs resulting from large networks. This was overcome by representing networks hierarchically as a group of clusters and treating each cluster separately.
This approach is tested through simulations of networks of various sizes. The results show that IAPTF with hierarchical network modeling outperforms previous approaches as well as human performance in terms of time, number of tested vectors and accuracy, especially in large networks. Another advantage of IAPTF is the ease of repetition for retesting similar networks, which is often encountered in real penetration testing. The results suggest that IAPTF is a promising approach to offload work from and ultimately replace human pen-testing.
Deterioration of vulcanized natural rubber sheets is associated with removal of calcium carbonate filler by wood-decay fungi Trichaptum abietinum and Trichaptum biforme
Authors: Sato Shin , Tien Hoan Kim , Inamori Wataru , Yoneyama Fuminori , Mase Akio
Published: May 2022

Wood-decay fungi may show potential in the degradation of rubber products in a natural and environmentally friendly process. Therefore, this study investigated the degradation of vulcanized natural rubber sheets by wood-decay fungi Trichaptum abietinum and Trichaptum biforme and the action of these fungi on the internal and external morphology, chemical composition, and physical properties of the rubber sheets. Scanning electron microscopy-energy dispersive X-ray spectroscopy analysis demonstrated that T. abietinum and T. biforme caused significant changes in the morphology of whole rubber. Crystals including calcium elements were formed on the rubber sheet after fungal treatment. Thermogravimetric analysis revealed a decrease in ash ingredient content corresponding to calcium carbonate in rubber treated with T. biforme for 3 months. These results suggest that the removal of the calcium carbonate filler from the rubber was associated with the deterioration of vulcanized natural rubber sheets by fungi. Furthermore, physical characteristics, durometer hardness, and tensile strength at the breakage point in rubber sheets were clearly altered after fungal treatment, although weight loss was not remarkable. We herein report for the first time that T. abietinum and T. biforme deteriorate vulcanized rubber sheets accompanied by transformation and translocation of calcium carbonate in vulcanized rubber.
Clinical implication of megestrol acetate in advanced cancer: A big data analysis from Health Insurance Review and Assessment (HIRA) database
Authors: Lee Chang Min , Kang Jung Hun , Go Se-Il
Published: May 2022

Purpose Megestrol acetate (MA) is used to manage anorexia and cachexia in patients with advanced cancer. This study investigated prescription patterns and impact on the survival and the venous thromboembolism (VTE) of MA in patients with advanced cancer.Methods In this study, a Health Insurance Review and Assessment (HIRA) service database was used to investigate differences in baseline characteristics, survival, and the incidence of VTE according to MA prescription patterns (i.e., prescription vs. no prescription) in patients diagnosed with metastatic gastric, colorectal, and pancreatobiliary cancers from July 2014 to December 2015.Results A total of 5,920 patients were included in this study. In total, 66.9% of the patients were prescribed MA. Pancreatobiliary cancer, older age, treatment in tertiary hospitals, and palliative chemotherapy were statistically significant predictive factors for MA prescription. Continuous prescription of MA was observed in 42.2% of patients. There was no statistically significant difference in survival between the MA and non-MA prescription groups. Among the 4,081 patients included in the analysis for VTE incidence, 5.4% and 2.9% were diagnosed with VTE during the follow-up period in the MA and non-MA prescription groups, respectively. However, there was no statistically significant difference in VTE diagnosis between the groups on multivariate analysis.Conclusions This study demonstrated that most patients with advanced gastrointestinal and pancreatobiliary cancer required MA prescription. The difference in the incidence of VTE was modest between the MA and non-MA prescription groups (not at the level of statistical significance on multivariate analyses).
Evaluation of the Performance of CMIP6 Model Simulations for the East Asia Region: Perspectives from Multiple Dimensions
Authors: Song Shuaifeng , Zhang Xuezhen , Gao Zhibo , Yan Xiaodong
Published: May 2022

A comprehensive model assessment on a 6-hourly scale from multiple dimensions is critical for model selection of dynamic downscaling to reduce uncertainties. In this study, we evaluated the performance of 13 models involved in the Coupled Model Intercomparison Project-6 (CMIP6) by comparing the simulated meteorological variables at the pressure levels of 850 hPa, 500 hPa, and 250 hPa, including 6-hourly air temperature, specific humidity, zonal wind, meridional wind, and geopotential height, to those from the ERA5 reanalysis data for the 1979-2014 period. The results indicated that the CMIP6 models could mostly reproduce the spatial pattern of the climatology. Most models underestimated air temperature and geopotential height while overestimating specific humidity and zonal and meridional wind speeds in the upper troposphere. Additionally, the interannual variability of zonal and meridional wind exhibits a relatively better performance but the limited ability for specific humidity at 850 hPa. Regarding the annual and diurnal cycles, CMIP6 models reasonably captured the annual cycle shape, while an overestimation was detected in simulating the diurnal amplitude, notably at 250 hPa. Based on a comprehensive rating index and overall rankings, our findings showed that no single model was identified as suitable for the simulation of any variables and regions. The models performed well for five variables, including MPI-ESM1-2-LR, MPI-ESM1-2-HR, TaiESM1 and UKESM1-0-LL, over East Asia. Then, according to the overall performance of the five variables and model accessibility, the optimal model varied by region and shared socioeconomic pathway (SSP) scenario. The MPI-ESM1-2-LR and MRI-ESM2-0 models were the two best models as lateral boundary conditions applied to seven climate scenarios over East Asia. This study provides valuable scientific references for selecting the optimal CMIP6 models for the projection of dynamic downscaling over East Asia and eight subregions.
Host-dependent clinical risk factors and inflammatory cytokine levels as predictive markers of respiratory syncytial virus bronchiolitis in infants
Authors: Narożna Beata , Langwiński Wojciech , Komasińska Paulina , Szczepankiewicz Aleksandra , Bręborowicz Anna , Szczawińska-Popłonyk Aleksandra
Published: May 2022

Purpose: Respiratory syncytial virus (RSV) is responsible for most cases of acute bronchiolitis in infants that require hospitalization. The infection is modulated by the local inflammatory response of the immune system via the production of pro-inflammatory cytokines. This study sought to determine the differences in the local immune response between children with RSV-positive and RSV-negative bronchiolitis. We also analyzed correlations between clinical parameters and molecular markers to define useful biomarkers of RSV infection.Methods: Children hospitalized due to acute bronchiolitis were recruited during three consecutive epidemiological seasons and divided into RSV-positive (n=42) and RSV-negative (n=81) groups. Clinical and demographic data were collected. RNA was isolated from nasopharyngeal aspirates and transcribed into cDNA. Gene expression of selected cytokines (IL-1β, IL-4, IL-8, IL-10, IL-12, IFN-γ and TNF-α) was analyzed via quantitative real-time PCR. Statistical analysis was performed in Statistica v.13.Results: RSV-positive patients were longer hospitalized (P=0.005) and required longer supplemental oxygen therapy (P<0.0001). Moreover, they had lower admission weight (P=0.017), lower partial pressure of oxygen (P=0.02) and higher CRP levels (P=0.02). Significantly higher rates of cesarean delivery (P=0.04) and familial atopy (P=0.006) were also observed in patients with an RSV infection. Comparison analysis revealed that IL-10, IL-12 and IFN-γ gene expression was significantly lower in patients with RSV than in patients without RSV (P=0.020, P=0.039 and P =0.003, respectively). In contrast, the expression of other cytokines did not differ significantly between the studied groups. Logistic regression analysis indicated that the expression of Th1 and Th2 cytokines, combined with clinical risk factors, significantly improved discrimination accuracy between RSV-positive and RSV-negative patients. Conclusions: Our results show that the expression of several cytokines significantly differs between children with RSV-positive and RSV-negative bronchiolitis, suggesting their involvement in the pathomechanism of RSV infection. The gene expression of IL-10, IL-12 and IFN-γ cytokines, lower admission weight, cesarean delivery and familial atopy could become clinical and diagnostic markers that facilitate the discrimination between RSV and non-RSV aetiology of bronchiolitis.
Long-term outcomes of cryoablation for biopsy-proven T1 stage renal cell carcinoma
Authors: Song Shangqing , Yang Qing , Gu Chengyuan , Yu Guopeng , Hua Bao , Gu Xin , Wang Linhui , Wang Zhong , Shi Guohai , Xu Bin
Published: May 2022

Objective To summarize our clinical experience of cryoablation in renal cell carcinoma (RCC) of Chinese population and to evaluate the long-term outcomes of laparoendoscopic single-site (LESS) cryoablation (LCA) as well as percutaneous CT-guided cryoablation (PCA) for biopsy-proven T1a and T1b RCC.Methods This was a multi-center, retrospective study investigating T1 stage RCC patients from 2011 to 2021. The patients were treated by LCA or PCA according to individual situation. Overall survival (OS), cancer-related survival (CSS) and progression-free survival (PFS) were evaluated for oncological outcomes and kidney function, complications, hospital stay were used to estimate technical outcomes. Results 163 consecutive patients were included. Among them, 59 cases were treated by LCA and PCA was performed in 104 cases. All operations were processed successfully. Mean diameter of the mass was (2.9±1.4) cm, median blood volume was 45ml (10~200 ml). The mean operation time was (84.0±24.5) min. The median postoperative hospital stay was 3 days (1~6 days). Compared with LCA, procedure time of PCA was shortened, the volume of bleeding was reduced, and the hospital stay was decreased. The overall adverse events rate was 9.8% (16/163). The mean pre-operative and post-operative eGFR of LCA were 77.6±15.3 ml/min and 75.6±17.4 ml/min, respectively. Analogously, the values of PCA were 78.7±12.9 ml/min and 76.7±14.3 ml/min. Mean follow-up time was 64.2 ± 30.2 months (range, 7-127 months). Local recurrence was observed in 13 patients (8.0%), 4 (6.8%) cases of LCA and 9 (8.7%) cases of PCA. PFS at 5 and 10 years were 95.5% and 69.2% for LCA and 96.7% and 62.8% for PCA. In total, 26 patients (16.0%) (11 patients from LCA and 15 from PCA) died throughout the follow-up period. OS at 5 and 10 years were 93.8% and 31.4% for LCA, and 97.4% and 52.7% for PCA. 6 patients (3.7%) (3 cases from LCA and 3 from PCA) died of metastatic RCC. CCS for LCA were 98.0% and 82.8% at 5 and 10 years, while the data were 100% and 86.4% for PCA. Conclusion LCA and PCA for T1 stage RCC provides satisfactory long-term oncological and renal function preservation outcomes, with acceptable complication rates.
Additive influence of extreme events and local stressors on coral diversity in the Mesoamerican Reef during the last decade
Authors: Muñiz-Castillo Aarón Israel , McField Melanie , González Jesús Ernesto Arias
Published: May 2022

Losing coral diversity is one of the most important consequences of coral reefs' ongoing degradation. Alternate: As the planet enters its sixth global extinction event, the loss of biodiversity due to coral reef degradation becomes of paramount importance. However, the loss of coral species diversity and its relationship to multiple global and local stressors remains largely untested on different temporal or spatial scales. This study evaluates the change in coral species diversity and its relationship to different stressors and habitat characteristics, using ecological data from 73 sites in the Mesoamerican Reef (MAR) and a variety of potential explanatory variables derived from remote sensing. We found a loss of coral diversity in the period analyzed, from 2010 to 2018. In addition to a decrease in diversity, there was also a considerable change in coral assemblages. The coral reefs that presented a greater loss of species were those with higher initial diversity and those with a higher number of annual bleaching risk events. Surprisingly, coral reefs exposed to hurricanes and turbidity with intermediate magnitude did not experience the same loss in diversity; some reefs even experience an increased diversity in this timeframe. The rate of increase in macroalgal cover was related to the decrease in coral diversity. Our results highlight the need to protect reefs with high diversity and constantly exposed to high heat stress events. These reefs should be considered sites of relevance in future conservation plans in the current context of global environmental change.
A Prospective Evaluation of Arrhythmias in a Large Tertiary Neonatal Intensive Care Unit
Authors: Chaudhry-Waterman Nadia , Nashed Lydia , Chidester Rachel , Nalewanski Alexandra , Bastawrous David , Busch Hayley , Jeong Hyungjoo , Baker Robin , Donnelly Kathleen , Cohen Mitchell
Published: May 2022

Introduction:
Arrhythmias in the neonatal period are common and can be classified as bradyarhythmias and tachyarrhythmias and as benign or non-benign. Neonatal arrhythmias are further differentiated between those with abnormalities in generation (non-sinus) and those with abnormalities in propagation. Because the neonatal myocardium is immature and operates at the peak of the Starling curve, significant changes in heart rate can result in a decline in cardiac output and compromise end-organ perfusion. This is especially true for premature neonates, those critically ill, or those with concomitant congenital heart disease. While sustained arrhythmias are frequently witnessed and recorded in tertiary neonatal intensive care units (NICU) very little data exists on the observance of non-sustained brady or tachyarrhythmias in this cohort. No prospective study has been performed on all neonates admitted to a large tertiary NICU throughout their entire stay. The purpose of this study was to prospectively evaluate the prevalence and type of arrhythmias in a large NICU population from admission to discharge.
Methods:
All neonates admitted to the NICU at Inova Children’s Hospital at Inova Fairfax Medical Campus between January 1, 2021 and April 1, 2021 were prospectively evaluated from admission to hospital discharge via continuous bedside monitoring reviewed every 24 hours. Concerning telemetry strips were reviewed by two team members as well as the senior electrophysiologist.
Results:
Two-hundred and one neonates (mean gestational age = 344/7 weeks’) were enrolled in the study. Admission length ranged from 1 to 195 days (total of 5624 patient days, median 16 days). Overall, 68% (N = 137) of admissions had one or more arrhythmias, the most common of which was sinus tachycardia (65%, N = 130), followed by sinus bradycardia (30%, N = 60). Clinically relevant arrhythmias were diagnosed in 6.5% of neonates. During the study period there were four deaths, none of which were directly attributable to a primary arrhythmia.
Conclusion:
Approximately 68% of neonates exhibited at least one arrhythmia. Although the vast majority of these arrhythmias were benign, clinically relevant arrhythmias were observed in 6.5%. Patients admitted to the NICU appear to have a relatively high burden of benign arrhythmias, but a relatively low burden of pathologic arrhythmias.
Divergent subgenome evolution in the allotetraploid frog Xenopus calcaratus
Authors: Knytl Martin , Fornaini Nicola R. , Bergelová Barbora , Gvoždík Václav , Černohorská Halina , Kubíčková Svatava , Fokam Eric B. , Evans Ben J. , Krylov Vladimír
Published: May 2022

Allopolyploid genomes are divided into compartments called subgenomesthat are derived from lower ploidy ancestors. In African clawed frogsof the subgenus Xenopus (genus Xenopus), allotetraploid species havetwo subgenomes (L and S) with morphologically distinct homoeol-ogous chromosomes. In allotetraploid species of the sister subgenusSilurana, independently evolved subgenomes also exist, but their cytogenetics have not been investigated in detail. We used an allotetraploid species in Silurana—Xenopus calcaratus—to explore evolutionary dynamics of chromosome morphology and rearrangements. We find that the subgenomes of X. calcaratus have distinctive characteristics, with a more conserved a-subgenome resembling the closelyrelated genome of the diploid species X. tropicalis, and a more rapidlyevolving b-subgenome having more pronounced changes in chromosome structure, including diverged heterochromatic blocks, repetitivesequences, and deletion of a nucleolar secondary constriction. Basedon these cytogenetic differences, we propose a chromosome nomenclature for X. calcaratus that may apply to other allotetraploids insubgenus Silurana, depending on as yet unresolved details of theirevolutionary origins. These findings highlight the potential for large-scale asymmetry in subgenome evolution following allopolyploidization.
Double-norm constrained dictionary learning image denoising algorithm
Authors: Ji Changpeng , He Lina , Dai Wei
Published: May 2022

An image denoising method combining fuzzy C-means structure clustering and sparse coding with double-norm constraints is proposed based on the features of a self-adaptive dictionary that can better use the image’s information. First, the fuzzy C-means structure clustering method is used to perform structural clustering on the original image after divided into small block; Second, the principal component analysis method is used to train the block image after the structure clustering into a super-complete adaptive sparse dictionary,then applied to image denoising through sparse coding; Finally, the denoising image is reconstructed by non-local self-similarity. Using the Set12 dataset and OASIS database, the experiments were performed under image with Gaussian white noise or pink noise. The experiments’ results show that the algorithm reduces the noise of noisy images and retains the edge and the texture information of the original image; Compared with KSVD, ISKR, EPLL, and other denoising algorithms, the proposed algorithm has achieved good results in visual similarity and peak signal-to-noise ratio.
How Alcohol and/or Tobacco Use and Raised Glycemia are Associated with Oral Hygiene Practices among Burkinabè Adults: Evidence from the first National Non-communicable Disease Risk Factors Survey
Authors: Diendéré Jeoffray , Bosu William Kofi , Ouédraogo Wend-Lassida Richard , Ouattara Seydou , Konsem Tarcissus , Zeba Augustin Nawidimbasba , Kouanda Séni
Published: May 2022

Socio-demographic correlates with oral hygiene practices are commonly investigated. The present study aimed to determine whether alcohol and/or tobacco use and hyperglycemia were associated with oral hygiene practices among Burkinabè adults. This descriptive, cross-sectional study included 4550 adults selected through multistage cluster sampling performed during the first WHO STEPS survey conducted in 2013 in Burkina Faso. The practices we considered were the frequencies of tooth cleaning, the fluoridated toothpaste use and the dentist visit within the past-six months. We collected data on self-reported alcohol and tobacco use and measured fasting blood glucose (FBG). About 82.8% of respondent reported they cleaned their teeth at least once a day, 31.5% cleaned them at least twice a day, 25.4% used fluoridated toothpaste, 2.2% had visited a dentist in the past six months, 38.8% used either alcohol or tobacco and 8.4% had raised FBG. After adjusting for socio-demographic factors, alcohol and/or tobacco use was an unfavorable factor for tooth cleaning at least once a day [aOR = 0.7 (0.6–0.8) p < 0.001], or at least twice a day [aOR = 0.6 (0.5–0.7) p < 0.001]. Moreover, raised FBG was negatively associated with cleaning tooth at least twice a day [aOR = 0.7 (0.5–0.9) p < 0.01] or the use of fluoridated toothpaste [aOR = 0.7 (0.6–0.9) p < 0.05]. Oral health education in addition to cardiovascular risk factor reduction should be efficiently integrated in the behavioral lifestyle interventions’ strategies for the non-communicable diseases’ prevention.
Efficient Maximum Power Point Tracking in Grid Connected Switched Reluctance Generator in Wind Energy Conversion System: An EMATSO Approach
Authors: Sridha S , V Vasan Prabhu , Velmurugan P
Published: May 2022

In this manuscript presents an efficient hybrid approach for fast and efficient MPPT in WECS. The system has MPPT based control of Switched Reluctance Generator (SRG) containing a hybrid Meta-heuristic algorithm. The hybrid proposed method is joint implementation of Mayfly Algorithm (MA) and Transient Search Optimization (TSO) named as enhanced MATSO (EMATSO) method. The reduction of speed error is the main aim of the proposed method. Depend on direct variation and quadrature current parameters the MA method is proposed to stimulate the maximum gain parameters of proportional integral (PI) controller with lowest error function. Here, the MA search behavior is enhanced using the efficient TSO algorithm. Based on speed variation of generator using MPPT method and loss reduction method the direct axis set point and the quadrature axis current parameters of WECS are developed. The proposed EMATSO method has enhanced the efficiency of the WECS with this proper control. At last, the proposed model is updated on MATLAB/Simulink platform and performance is compared to other methods like GA, ALO, TSA and MA
new subgenus and a remarkable new species of Domene from South China, with additional records of the genus from China, Taiwan, and Vietnam (Coleoptera: Staphylinidae: Paederinae)
Authors: Assing Volker
Published: May 2022

Domene hybrida spec. nov. (China: Guizhou) is described, illustrated, and distinguished from other species of the genus known from China. The species is peculiar in that it combines morphological characters found in Domene Fauvel, 1873 with characters observed in other genera of Lathrobiina, particularly Lobrathium Mulsant & Rey, 1878 and Pseudobium Mulsant & Rey, 1878. Unlike all other congeners previously recorded from China, it does not belong to the subgenus Macromene Coiffait, 1982, which is why it is assigned to a subgenus of its own, Lobramene subgen. nov. Additional records of six Domene species are reported from China, Taiwan, and North Vietnam. Including two species of doubtful generic affiliations, the genus now includes 86 named species, 22 of which have been recorded from China, three from Taiwan, and two from Vietnam.
Taxonomic acts
Lobramene subgen. nov. – urn:lsid:zoobank.org:act:CFC20457-493D-4034-B935-D604A6BA2340Domene hybrida spec. nov. – urn:lsid:zoobank.org:act:14A1FF54-AB49-4398-A450-AFE78E46105C
Revision of Geostiba of the West Palaearctic region. XXVIII. New species and records from the Georgian Caucasus (Coleoptera: Staphylinidae: Aleocharinae)
Authors: Assing Volker
Published: May 2022

A study of 485 specimens of Geostiba Thomson, 1858, 482 of which were collected during three field trips to West Georgia conducted in 2021, yielded eleven species, two of which are described and illustrated: Geostiba (Sibiota) brevifistula spec. nov. (Georgia: Kvemo Svaneti) and G. (S.) egrisica spec. nov. (Georgia: Samegrelo-Zemo Svaneti). Both species belong to the G. bituberculata group. Geostiba (Geostiba) sororcula Assing, 2001, a species previously known only from Northeast Turkey and Armenia, is reported from Georgia for the first time. The distributions of five species are mapped. The Geostiba fauna of the Caucasus region sensu lato is now represented by a total of 50 species, 30 of which belong to the subgenus Sibiota Casey, 1906.

Taxonomic acts

Geostiba brevifistula spec. nov. – urn:lsid:zoobank.org:act:C9599E3F-3AB0-4C10-980C-862F374E3EE8 Geostiba egrisica spec. nov. – urn:lsid:zoobank.org:act:267A9CC9-F7A1-4CED-8594-1CE8CF16C0E9
Espresso İçeren Kahve İçeceklerinin Antioksidan Kapasite, Toplam Fenolik Bileşen ve İn-vitro Biyoerişilebilirliğinin Karşılaştırılması
Authors: YILDIZ Elif
Published: May 2022

Kahve günlük yaşantımızda önemli bir yere sahip olan ve en sık tüketilen içeceklerden biridir. İçeriğindeki biyoaktif bileşenler sayesinde sağlık üzerinde antioksidan, antihipertansif, anti-inflamatuar, immünoprotektif, anti-karsinojen etkiler göstermektedir. Çalışma kapsamında, ticari olarak tüketime sunulan Espresso, Americano, Macchiato, Latte, Cappuccino ve Mocha kahve içeceklerinin antioksidan kapasite (ABTS ve DPPH Metotları) ve toplam fenolik bileşen miktarı (Folin-Ciocalteu Metodu) açısından analiz edilerek, içeceklerin biyoaktif potansiyellerinin kıyaslanması amaçlanmıştır. En yüksek değerler en yoğun kahve içeriğine sahip olan Espresso örneğinde belirlenmiş olup; ekstrakte edilebilir, hidrolize edilebilir, biyoerişilebilir fenolik fraksiyonları sırasıyla TEAKABTS sonuçlarına göre 28.15, 35.04, 30.28 μmol Troloks mL-1; TEAKDPPH sonuçlarına göre ise 14.69, 17.98, 9.84 μmol Troloks mL-1 olarak belirlenmiştir. Kahve örneklerinin içeriğindeki süt miktarı arttıkça antioksidan kapasite ve toplam fenolik bileşen değerlerinde azalma gözlemlenmiştir. Sütün buhar ile muamele edilerek köpük halinde eklenmesi, sıcak olarak eklenmesine göre nispeten daha yüksek değerler göstermiştir. Örneklerin % biyoerişilebilirlikleri ise, toplam fenolik bileşen içeriğine göre % 41-48 arasında değişmiştir.
Bal Arılarının Sindirim Kanalında Bulunan Probiyotik Kökenli Bifidobacterium sp.’nin Enzimatik ve Bibliyometrik Analizi
Authors: YÜCEL Halit , EKİNCİ Kübra , KARAMAN Altuğ , YAZDIC Fadime , KAR Bülent
Published: May 2022

Bal arıları (Apis mellifera) bal, polen, arısütü, propolis, bal mumu ve arı zehiri gibi ürünleri üreten ve birçok doğal ve endüstriyel bitkinin tozlaşmasında vektör işlevi gören eşsiz bir süper organizmadır. Son zamanlarda meydana gelen koloni kayıpları sebepleri arasında bağırsak mikroflorasının etkisi ve buna bağlı olarak bağışıklık sistemi ön plana çıkmaktadır. Arıların sindirim tüpünde bulunan bakterilerin çeşitliliği ve yoğunlukları sonucu bağışıklık sistemleri etkilenebilmektedir. Bu etkinin olumlu yönde olabilmesi için bağırsak mikroflorasının doğal ve dengeli olması gerekmektedir. Bağırsakta bulunan bakteri popülasyonları arasında önemli bir yere sahip olan probiyotik kökenli Bifidobacterium sp.’nin sahip olduğu enzim aktivitesi hem diğer simbiyont mikroorganizmalar üzerinde hem de konakçının beslenmesinde kritik bir etkiye sahiptir. Bundan dolayı bu çalışmamızda Bifidobacterium sp.’nin önemini vurgulamak için enzim aktivitesi ve bibliyometrik analizler yapılmıştır. Optimum glikozit hidrolaz enzim aktivitesinin hesaplanması için farklı pH, sıcaklık ve substratlar tercih edilmiştir. Enzim aktivitesinin analizi sonucu Bifidobacterium sp.’nin glikozit hidrolaz etkinliği (pH 5.0 ve 30oC) tespit edilmiştir. İnülin substratının daha fazla kullanılması probiyotik Bifidobacterium sp. için doğal prebiyotik kaynağı olduğunu göstermiştir. Aynı zamanda yeni nesil prebiyotik kaynağı olarak bilinen ksilanın hidrolizi de gerçekleşmiştir. Bibliyometrik analiz için Web Of Science ile Scopus veri tabanındaki korelasyon bağlantıları VOS viewer yazılımı yardımıyla sonuçlandırılmıştır.
Formas discursivas contemporáneas de juventud y sus límites: la construcción mediática de jóvenes de las clases subalternas en Córdoba, Argentina (2014)
Authors: Espoz Dalmasso María Belén , Boito María Eugenia
Published: May 2022

El artículo tiene como objetivo señalar las tendencias a partir de las cuales la ‘juventud’ se configura en una forma particular de vivencia en las ciudades del sur global. Ello a partir de la identificación de los marcos de interpretación que construyen los medios de comunicación masiva en torno a sus valores y sus límites (los de los jóvenes de los sectores populares de la ciudad de Córdoba, Argentina). Para la descripción y análisis seleccionamos un corpus gráfico, de dos periódicos (La Voz del Interior y La mañana de Córdoba en su versión digital) y la metodología seleccionada el análisis del discurso, desde los aportes de Bajtín y Voloshinov, y algunos conceptos fundamentales de la crítica ideológica.
ECONOMIA SOLIDÁRIA NO BRASIL: Elementos de uma dialética e dialógica do fracasso – causas possíveis, correções necessárias, desafios inevitáveis
Authors: Oliveira Edson Marques
Published: May 2022

Realiza-se um estudo de caso sobre economia solidária entre Brasil e Portugal,tendo como ponto de partida uma experiência prática de incubação de tecnologias sociais e empreendimentos, na Unioeste, Paraná Brasil e Universidade de Coimbra, em Portugal. Ao estudar as causas do fracasso, identificou-se princípio e conceito da dialética e da dialógica do fracasso, e considerou-se esse momento como oportunidade de aprendizagem e não de derrota. Os principais resultados apontam que os princípios de autogestão,cooperação e solidariedade são afetados pelos processos de individualizaçãogerados pela lógica do hiperconsumo, desequilíbrio entre competição ecooperação, distorção da ética da autenticidade, processo acentuado de satisfações pessoais, acima das realizações e necessidadescoletivas, os quais comprometem a cooperação e a solidariedade numaperspectiva emancipatória, gerando assim um paradoxo da cooperação e seuenfraquecimento e fragilizando o sentido de solidariedade no contexto contraditório da sociedade do consumo, impondo a necessidades de correções necessárias e confrontos inevitáveis.
A AMÉRICA COMEÇA NOS PIRINEUS: As relações Ibéricas na “raia” portuguesa e a fronteira da Europa com a América Latina
Authors: Moura Filho José Luiz
Published: May 2022

Discute-se o arranjo institucional denominado Euroregião Galiza/Norte de Portugal, para contribuir no processo de integração em curso na América do Sul – MERCOSUL - tomando-se por parâmetro a atual organização política, econômica e socio-espacial de aglomerados transfronteiriços como Chuí/Chuy, na fronteira do Brasil com o Uruguai. Teoricamente centrar-se-á nas categorias “cooperação sem governo (central)” e “complementar para competir”, que pautam a cooperaçãotransfronteiriça naquela porção da UE, sem descuidar de conceitos caros ao ordenamento territorial como “região”, “fronteira” e “cultura”, historicamente relativos e fugazes em momentos como oque vivem os Estados-Nação, na presença de fenômenos como a globalização. A investigação da ocorrência de metodologia de análise socio-espacial semelhante àquela consistente na dialética entre oscircuitos superior e inferior da economia urbana (Milton Santos, 2004), flagrante no espaço paradigmático através da presença de free shop e vendedores ambulantes, poderá contribuir para a superação dodilema “integração regional x concorrência local”. Parte-se da concepção de uma “cultura de fronteira” como elemento de integração das realidades territoriais envolvidas, sobretudo quando articulamEstados Nacionais em blocos, como o MERCOSUL e a UE. Naquele caso  observa-se que a ação estatal voltada ao desenvolvimento urbano responde a pressões do circuito superior, aprofundando assimetrias nos espaços urbanos compartilhados. A complementaridade entre os circuitos da economia urbana nestas cidades aparece como solução que, somada à ação do Estado para dispersão no território de equipamentos sociais, possibilita a (re)apropriação, pelas populações locais, dos espaços tomados pelo econômico. Isso acaba por conformar uma nova identidade, portadora de valores que estão na base de uma comunidade, objetivo maior a ser perseguido por projetos de integração e desenvolvimento regional. A relação com a UE, então, se dá em razão da similaridade de condições jurídico-políticas (poder local/tradição municipalista) e de indicadores socioeconômicos, restando, pois, analisar os arranjos político-institucionais indispensáveis.
A tradição do Festival de Caretos de Salsas ou os relatos da mudança social
Authors: Lafita Savina
Published: May 2022

Numa perspectiva que permite analisar a festa dos Caretos de Salsas como fonte de discursos e práticas de género, este trabalho, que situa a festa num processo mais amplo de revitalização e patrimonializaçãodas festas de inverno no nordeste de Portugal, pretende refletir sobre a maneira como a mudança semântica que a performance sofreu interpela as memórias individuais colaborando no processo de mitificação da tradição.
Representatividade e Dilemas da Juventude Gay na Cena Independente Potiguar
Authors: Moreira Allyson Darlan , De Moura Américo Felipe Gustavo
Published: May 2022

Dirigido pelo potiguar Lucas Fernandes, O Mistério das Noites Brancas (Brasil, 2018) é uma produção independente realizada pelo coletivo Drone em Chamas em parceria com a produtora Jubarte Filmes, o Departamento de Comunicação Social da Universidade Federal do Rio Grande do Norte e com participação voluntária de uma equipe de atores, técnicos e assistentes. O longa-metragem do gênero drama é inspirado no livro “Noites Brancas” do escritor russo Fiodor Dostoiévski, e teve sua estreia em abril de 2018 como parte integrante da mostra competitiva do Cine Fest RN, realizado no Cinemark Natal, no Rio Grande do Norte.
Ensaios sobre educação e complexidade
Authors: Batista Ozaias Antônio
Published: May 2022

Resenha do livro Pensamento complexo e educação.
Cínico
Authors: Senna Alecrides Jahne Raquel Castelo Branco de
Published: May 2022

Poesia
Prêmio Framboesa de Ouro
Authors: Marques Nelson
Published: May 2022

Framboesa de Ouro é um prêmio cinematográfico dos Estados Unidos da América criado em 1981 para escolher os piores filmes produzidos pelo cinema americano. Alguns o classificam como um prêmio humorístico, mas muitos também o consideram muito mais um prêmio satírico. Ele foi concebido desde o princípio como uma paródia bem-humorada do Oscar, inclusive seguindo à risca o cronograma de premiação anual às melhores produções do cinema segundo o conceito da Academia Americana de Cinema. A intenção da homenagem é a de premiar o que passou de pior nas telas de cinema americanas.