bluuebunny/crossref_metadata_2025 huggingface dataset:
SOCIAL COHESION IN THE REPUBLIC OF MOLDOVA: REALITIES AND PERSPECTIVES
Authors: Victor MOCANU , Ludmila MALCOCI , Angela MOCANU
Published: July 2021

Strengthening social cohesion is one of the main directions of the Moldova 2030 strategy. At the same time, the Association Agreement between the Republic of Moldova and the EU stipulates social inclusion, poverty reduction, social cohesion, sustainable development and improving the quality of life as social policy priorities. This article analyzes the theoretical approaches of the concept of social cohesion and presents the results of sociological research on social cohesion in the Republic of Moldova conducted in 2020. The sample includes 1202 respondents and is representative by place of residence (urban / rural), sex, age, level of education. The qualitative study included interviews with 90 experts, representatives of local public authorities, NGOs and the private sector and 3 focus groups. The research was carried out within the project “Training and strengthening social cohesion in the Republic of Moldova in the context of rapprochement with the European Union”. As key aspects of social cohesion were analyzed: self-identification of the degree of belonging of Moldovan citizens to the Republic of Moldova, perceptions of solidarity with other citizens, social trust, participation and inclusion of citizens in political, social and economic processes. The research results showed that the level of cohesion and social solidarity in the Republic of Moldova is quite low. The COVID-19 pandemic has deepened social distancing, uncertainty about the future, poverty and the marginalization of certain groups of the population and has further contributed to lowering the level of social cohesion.
Modeling of Coupling Effects in Neural Networks for Ship Motion Prediction
Authors: Zhang Chong , Hu Peida , Zhang Rong , Wu Qiuping , Yang Anlan
Published: July 2021

This work has been submitted to the IEEE for possible publication. Copyright may be transferred without notice, after which this version may no longer be accessible.

In this article, a novel NN structure that combines factorization machines, wavelet transform, and the RNN structure is proposed to improve the accuracy of ship motion prediction. In comparison with traditional NN methods, the proposed structure explicitly models the coupling effects in ship motions, thereby significantly improving the performance of RNN-based models. The proposed structure also provides interpretability of the coupling effects, which helps build white-box NN models for ship motion prediction. Moreover, the proposed structure is lightweight enough for real-time prediction while remaining frequency-aware and sequence-aware.
Automated Waste Segregation using Convolution Neural Network
Authors: Ravishankar Anagha
Published: July 2021

The key to efficient waste management is to ensure segregation of
waste and resource recovery. Waste is usually segregated on the basis of
whether it is biodegradable or non biodegradable. A major challenge with
respect to this is that waste is not segregated before collection and is thrown
into dustbins nonetheless. These end up as huge piles of waste in dump yards,
which needs to be segregated.
Waste segregation is currently being done manually by
the Municipal Corporation. These results in unsanitary working conditions for
the people who need to perform this task. Despite being provided with the
necessary equipment, they run the risk of catching infections from the waste
they work with. Automation of this process will be beneficial for the people
who work on this, by reducing health hazards.
Deep-Learning-Based Non-Coherent DPSK Multiple-Symbol Differential Detection in Single-User Massive MIMO Systems
Authors: Mahmoud Omnia , El-Mahdy Ahmed , Fischer Robert F. H.
Published: July 2021

In this work, non-coherent massive MIMO differential phase-shift keying modulation (DPSK) detection is considered to get rid of the complexity of channel estimation. However, most of the well-performing DPSK detection techniques require high computational complexity at the receiver. The use of deep-learning is proposed for detecting the transmitted DPSK symbols over a single-user massive MIMO system. We provide a multiple-symbol differential detection implementation using deep-learning. Two deep-learning-based multiple-symbol differential detection receiver designs are proposed and compared with differential detection (DD), decision-feedback differential detection (DFDD), and multiple-symbol differential detection (MSDD) for the same system parameters. Where multiple-symbol differential sphere detection (MSDSD) is used to implement MSDD. The results show that the proposed deep-learning-based classification neural networks outperform decision-feedback differential detection and achieve an optimal performance compared to conventional multiple-symbol differential detection implemented by multiple-symbol differential sphere detection.
Towards the Optimal RF Sensing Strategy for IoT Applications: An Ice Sensing Case Study
Authors: Wagih Mahmoud , Shi Junjie
Published: July 2021

Remote ice detection has recently emerged as an application of Radio Frequency (RF) sensors. While RF sensing is a feasible approach used for detecting various stimuli, the optimal system architecture and design strategy for RF-based sensing in future Internet of Things (IoT) systems remains unclear. In this paper, we propose a systematic methodology for designing an RF-based sensing system, applicable to a plethora of IoT applications. The proposed methodology is used to design printable antennas as highly-sensitive sensors for detecting and measuring the thickness of ice, demonstrating best-in-class sensory response. Antenna design is investigated systematically for wireless interrogation in the 2.4 GHz band, to support a variety of IoT protocols. Following the proposed methodology, the antenna's realized gain was identified as the optimum parameter-under-test. The developed loop antenna sensor exhibits a high linearity, resilience to interference, and applicability to different real-world deployment environments, demonstrated through over 90% average ice thickness measurement accuracy and at least 5 dB real-time sensitivity to ice deposition.
Spatiotemporal Graph Convolutional Recurrent Neural Network Model for Citywide Air Pollution Forecasting
Authors: Le Van-Duc
Published: July 2021

This paper applies a Spatiotemporal Graph Convolutional Recurrent Neural Network which is a tight combination of a Graph Neural Network (GNN) to a Recurrent Neural Network (RNN) architecture for air pollution forecasting in long-term for the entire city. Our model can effectively learn the spatial and temporal features of the air pollution data and its influential factors (e.g. weather, traffic, external areas) at the time. Our method achieves better performance than a state-of-the-art ConvLSTM model in air pollution forecasting and a hybrid GNN-based model that separates GNN and RNN in discrete layers.
Understanding the Effects of Exponentially Decaying DC Currents on the Dual dq Control of Power Converters in Systems with High X/R
Authors: Mota Daniel , Tedeschi Elisabetta
Published: July 2021

This paper was accepted for presentation at the IEEE CPE-POWERENG 2021 conference held in Florence, Italy, between the 14th and 16th of July 2021.

It investigates the root causes of detrimental oscillations in the dc link voltage of an energy storage system using a dual dq controller, operating at a high-voltage ac grid with high reactance-resistance ratio. Dual dq controllers are recommended in the literature for power converters operating under unbalanced, fault, or reduced voltage conditions. They employ two separated rotating reference frames, one for the positive and one for the negative sequence. The causes of the oscillations are investigated both theoretically and by time-domain computer simulations. As a result of the simulations, the performance of two dual controllers used in the industry is compared. In the presence of exponentially decaying dc currents, the filtering techniques employed by the controllers affect differently the performance of the proportional-integral regulators and disturb the feed forwarding and dq decoupling schemes. Ultimately, this results in undesirable oscillations in the dc-link voltage. This paper sheds light on how a fundamental phenomenon of three-phase ac systems can critically affect the control of power electronic converters. It provides a valuable insight into a possible root cause of oscillations in large electrical system applications with a considerable power converter penetration, such as large industrial plants striving for reducing greenhouse gas emissions.
Massimo Quaini: la Liguria labirinto e laboratorio
Authors: Gemignani Carlo Alberto
Published: July 2021

Liguria was the great ‘action scenario’ for Massimo Quaini. A region that, thanks to historical and environmental conditions, allowed him to read in advance phenomena and dynamics that would later occur at a national scale. This contribution does not pretend to exhaust the substance of a relationship that goes beyond the scientific level and involves deep existential bonds, but only to provide some elements to draw a first map of the scientific reasons that have linked the scholar to his land of belonging. This reflection will hopefully serve to define how much Liguria is found in Massimo Quaini’s geographical thinking and how much the Ligurian society should still make use of the sharp portraits the scholar has been able to dedicate to her.
Imago proelii. La cartografia storica della Prima Guerra Mondiale dal Museo Storico della Terza Armata: spigolature per una analisi tipologica e semiologica
Authors: Dai Prà Elena , Gabellieri Nicola
Published: July 2021

International historiography has extensively assessed the innovations in war practice experienced during the First World War. However, the consequences of trench warfare in military cartographic production have not been fully investigated yet. Following this line, the essay presents the cartographic corpus of the historical archive of the Terza Armata (Third Army); the Terza Armata had a fundamental role in the conflict, settling on the Piave river after Caporetto and leading the final advance towards Istria. The analysis of the collection, which is still unpublished, can open a new front of research aimed at developing categories of semiological analysis and typological classification of military maps as sources produced in fieri, i.e. manuscript IGM maps that were constantly updated during war operations. First, the cartographic corpus is presented; second, a first typological classification and a semiological decoding of maps are proposed, based on the interpretation of the symbols used, of the legend and of the methods of representation. In particular, the contribution focuses on tactical maps, i.e. cartographies that were continuously updated in proelio to document the evolution of war events on the front line.
Ophthalmological masks of a new coronovirus infection
Authors:   Tyumen State Medical University, Tyumen, Ponomareva M. N. , Sakharova S. V. ,   Regional Clinical Hospital No 2, Tyumen, Markova A. O. ,   Tyumen State Medical University, Tyumen, Turlybekova D. A. ,   Regional Clinical Hospital No. 2, Tyumen, Kalyuzhnaya E. N. ,   Tyumen State Medical University, Tyumen, Karpova D. A. ,   Tyumen State Medical University, Tyumen, Petrov I. M. ,   Tyumen State Medical University, Tyumen
Published: July 2021

Goal. To present a clinical and statistical analysis of the somatic status and ophthalmological manifestations of the new coronavirus infection in patients treated in a round-the-clock ophthalmological hospital. Materials and methods. The clinical, laboratory and instrumental data of 12 patients with a new coronavirus infection treated in the ophthalmology department of the adult hospital of the Regional Clinical Hospital No. 2 from February 2020 to May 2021 were analyzed. Results. The structure of nosologies is represented by the following diseases: corneal ulcer – 33.3% (4/12), of which men – 25% (3/12), women – 8.3% (1/12); phlegmon of the orbit – 8.3% (1/12); combined corneal and vascular lesions (keratouveitis) – 16.6% (2/12); nerve tissue damage (optic neuritis, neuroretinovasculitis) – 16.6% (2/12); vascular lesions are represented by chronic iridocyclitis OD in the acute stage and panuveitis of fungal etiology – 16.6% (2/12); the lesion of the central retinal vein (CVC) is represented by partial thrombosis of its upper-temporal branch – 8.3% (1/12). The development of the disease is associated with the presence of systemic atherosclerosis and hypertension, or trauma to the visual organ. Conclusions. Ophthalmic masks of a new coronavirus infection are more common in men. The trigger factors include systemic atherosclerosis, arterial hypertension, or trauma to the eyeball, blood pathology, chronic diseases of the gastrointestinal tract, diabetes mellitus.
Evaluation of the effectiveness of the method of microinjection autotransplantation of tissues based on immunological parameters
Authors:   City Clinical Hospital No. 8, Chelyabinsk, Teryushkova Z. I. , Vazhenin A. V. ,   South Ural State Medical University,   Chelyabinsk Regional Clinical Center of Oncology and Nuclear Medicine, Vasiliev V. S. ,   South Ural State Medical University, Vasiliev S. A. ,   South Ural State Medical University, Timerbulatov V. M. ,   Bashkir State Medical University
Published: July 2021

Relevance of the topic. Chronic radiation damage to the rectum occurs in 5-10% of patients. The development and application of a method for treating patients with post-radiation rectal injuries using autologous regenerative cells of adipose tissue in a clinic will make it possible to achieve high results in treatment. Purpose – to conduct a comparative analysis of the effectiveness of the method of microinjection autotransplantation of tissues based on immunological parameters. Patients and methods. The study involved 66 patients – women aged 28 to 83 years inclusive with complications of radiation therapy (rectovaginal fistulas, radiation proctitis, radiation ulcers). We carried out a comparative analysis of the condition of patients with post-radiation injuries before and after treatment, and also evaluated the role of microinjection autotransplantation of tissues in the treatment of post-radiation injuries of the rectum. The results and effectiveness of treatment were judged by changes in the main immunological parameters. Results. Our results indicate the high efficiency of the method of microinjection autotransplantation of adipose tissue in the treatment of post-radiation damage to the rectum. Impaired repair of damaged tissue in patients with post-radiation damage to the rectum is accompanied by changes in the T-cell level of immunity and an imbalance of pro- and anti-inflammatory cytokines, which leads to a decrease in reparation capabilities, prolonged non-healing of the defect, and progression of the disease. The revealed changes in cellular immunity and cytokine profile are mutually aggravating. At the same time, the use of SVF makes it possible to normalize these indicators, and, accordingly, allows achieving sustainable results in treatment, reducing the risk of complications, and preventing the likelihood of relapses. All this will allow in a short time to objectively assess the somatic status of the patient, the degree of operational risk, choose the most adequate treatment tactics, predict the outcome of treatment in each specific case, and will also give high clinical results (elimination of inflammation, epithelialization of the defect), and will improve the quality of life of patients. Conclusion. The use of SVF will not only eliminate the pathology, but also prevent further relapses by stimulating the regenerative capabilities of the affected tissues, as well as by achieving an immunostimulating, anti-inflammatory effect.
Peculiarities of tactics and surgical intervention in fresh iatrogenic damage of the common liver duct
Authors:   Regional Clinical Hospital No. 1, Tyumen, Chakhchakhov Ya. A. ,   Tyumen State Medical University, Tyumen, Gibert B. K. ,   Regional Clinical Hospital No. 1, Tyumen,   Tyumen State Medical University, Tyumen
Published: July 2021

The aim of the study was to select the most optimal method for completing the operation in case of "fresh" iatrogenic damage to the common hepatic duct, which ensures a favorable course of the postoperative period and preparation for the subsequent reconstructive operation. Material and methods. The study was based on the analysis of the results of surgical treatment of 58 patients with iatrogenic damage to the extrahepatic bile ducts (EPBD) for the period from 1998 to 2018. All patients had complete "fresh" transverse transection or clamping (clipping, ligation) of the common hepatic duct during cholecystectomy. In the first group (40 patients), the operation was completed by drainage of the common hepatic duct with a "free" position of the drainage under the liver and drainage of the subhepatic region; in the second group (18 patients), the drainage of the bile duct was fixed in the bed of the gallbladder, with the formation of a Maidl-type jejunostoma to return bile. Research results and their discussion. All patients (58 people) were initially operated on in hospitals in the Tyumen region and the city of Tyumen. 32 patients (55%) underwent open cholecystectomy, 26 (45%) – laparoscopic. The operation was performed in 13 patients (22%) as planned, in 45 (78%) as an emergency. In 40 (69%) operated patients, when the gallbladder was removed, the common hepatic duct was cut, in 18 (31%) it was clipped (ligated). Out of 40 patients (first group), bile duct transection occurred with open cholecystectomy in 29 (72.5%) people, in 11 (27.5%) with laparoscopic intervention. In all, the trauma of the hepatic duct was noticed by the operating surgeon during the operation. In accordance with the adopted tactics, the surgeon through the CMH contacted the experienced surgeon on duty at the Regional Hospital (GBUZ TO "OKB № 1"), with whom he agreed on the method of completing the operation. Conclusion. The lack of experience of hospital surgeons both in solving a tactical problem, when crossing an AKI or clipping it, and in performing a reconstructive operation after an injury is detected, we consider it expedient to introduce drainage into the proximal section of the intersected duct and transport the patient to a hospital department where there are specialists with such experience. operations. Fixation of the drainage of the common hepatic duct in the bed of the gallbladder, the formation of a Maidl-type jejunostoma with a complete return of bile to the intestine can effectively prepare the patient for reconstructive surgery, improve the technical conditions for its implementation.
The role of blood glucose self-monitoring in assessing glycemic variability in patients with type 1 diabetes mellitus
Authors:   Tyumen State Medical University, Tyumen, Sudnitsyna A. S. , Suplotova L. A. ,   Tyumen State Medical University, Tyumen, Romanova N. V. ,   Regional Clinical Hospital No. 2, Tyumen
Published: July 2021

In the context of the increasing prevalence of diabetes, an important task is to educate the patient on the mandatory self-monitoring of blood glucose levels (SMBG), which is an integral component of the treatment and prevention of acute and chronic complications of the disease. On the basis of the SMBG data, it is possible to assess the parameters of glycemic variability, which is the fluctuations in blood glucose during the day and differences in blood glucose levels at the same time on different days. Due to the fact that GV is one of the main criteria for assessing the quality of glycemic control, its correction is considered as a new goal in the treatment of patients with diabetes.
Partial hepatectomy against the background of superinvasive opisthorchiasis does not provoke carcinogenesis
Authors:   Tyumen State Medical University, Tyumen, Lazarev S. D. , Khadieva E. D. ,   District Clinical Hospital, Khanty-Mansiysk,   Khanty-Mansiysk State Medical Academy, Khanty-Mansiysk, Bychkov V. G. ,   Tyumen State Medical University, Tyumen, Vikhareva L. V. ,   Tyumen State Medical University, Tyumen, Orlov S. A. ,   Tyumen State Medical University, Tyumen, Zharkov N. V. ,   City Clinical Hospital No. 40, Moscow
Published: July 2021

Research goal: identification of the risk of oncogenesis in the liver under the influence of 2 promoter factors – partial hepatectomy (PHE) performed against the background of superinvasive opisthorchiasis (SO) in Syrian hamsters. Material and methods. SO was modeled by infecting animals (n = 86) with 50 metacercariae of O. felineus. Superinvasions (50 metacercariae) were repeated 6 and 16 days after primary infection. PHE – removal of the middle lobe of the liver – 17.3-17.7% of the organ weight was performed according to the method of G. M. Higgins, K. M. Andersson 16 days after the last superinvasion. The quantitative assessment of the regenerative process after PHE was determined by the coefficients of regeneration completeness (%) by the formula Кпрп = (М1 – М2) / М3 × 100. The histological specimens were stained with hematoxylin and eosin and by the methods of Van Gieson, Slinchenko, Samsonov, Kupriyanov. IHC–reactions were carried out with antibodies to Ki–67, CD31, CD34, CD117, Oct 4, and α–fetoprotein. Electron microscopic analysis was performed on a “JEM – 100CX” microscope (JEOL, Ltd., Japan). The quantitative characteristics were processed using the statistical software Microsoft Excel (2019) and the Statistica package (version 12.6). Results. Analysis of the obtained data indicates that by the 16th day after PHE, 3 zones have formed in the liver: zone A – the stump, zone B – is adjacent to the wound zone A, zone C – is adjacent to zone B. By the 16th day after PHE, expressed proliferation processes of the CD31, CD34, Oct 4, CD117–positive cells and differentiation into endothelial cells, cholangiocytes, hepatocytes with the formation of vessels are noted. At a later date of the experiment, hepatocyte fields with the presence of α–fetoprotein in the cytoplasm, cholangiocellular tubules were formed; at a later date (23 days), ducts lined with a cylindrical epithelium of normal structure were identified. The epithelial lining of the preexisting ducts is multi–row by the end of the experiment; no tumors were found in the liver in the experimental group. An increase in liver mass was noted in the control group (SO) by 8.2%, in the experimental group – 24.7%. Conclusion. The liver with partial hepatectomy against the background of superinvasive opisthorchiasis is an organ with permanent proliferation of CCD and HCD cells, hyperregeneration and a significant increase in mass. In the presence of 2 promoters without initiators, the risk of carcinogenesis does not increase.
Liver pathology in spontaneous superinvasive opistorchiasis in synanthropic animals in hyperendemic hotbed
Authors:   Khanty-Mansiysk State Medical Academy, Khanty-Mansiysk, Khadieva E. D. ,   District Clinical Hospital, Khanty-Mansiysk, Kulikova S. V. ,   Tyumen State Medical University, Tyumen, Lazarev S. D. ,   Tyumen State Medical University, Tyumen, Uruzbaev R. M. ,   Tyumen State Medical University, Tyumen,   Multidiscipline Clinical Medical Center "Medical city", Tyumen, Galdina A. V. ,   Tyumen State Medical University, Tyumen, Bychkov V. G. ,   Tyumen State Medical University, Tyumen
Published: July 2021

Opisthorchiasis is a parasitic disease that represents a serious medical and social problem for the population living in the area of vegetation of opisthorchis larval stages. The parasitic disease significantly reduces the activity and potential of the indigenous and newcomer population of hyperendemic hotbeds. Wild and domestic animals are actively involved in maintaining the epidemiological tension of the hotbeds, among the latter, cats and dogs infected with opisthorchiasis, in which the pathomorphology of the liver and oncogenesis have not been studied, are of great importance. On the basis of sufficient factual material, this gap has been partially filled in this work. Aim. To determine the features of pathomorphological transformations of the liver and pancreas in spontaneous opisthorchiasis in cats and dogs, to identify the possibility of oncogenesis against the background of superinvasive opisthorchiasis (SO) in synanthropic animals of a hyperendemic hotbed. Material and methods. The pathomorphology of the liver and pancreas in 48 animals was studied. The specimens were processed by histological, histochemical methods, the indices of the area of inflammatory infiltrates, granulomas, necroses were calculated, the indicators were subjected to statistical processing. Results. In superinvasive opisthorchiasis, cats and dogs develop a complex of structural proliferating transformations characteristic of other hosts of the parasite – humans, laboratory animals. In synanthropic animals, against the background of SO, the development of malignant neoplasms is possible. Conclusion. Superinvasive opisthorchiasis in synanthropic animals causes permanent proliferation of progenitor cells of the liver and pancreas, which provides the promotor effect of oncogenesis in the liver – the main econiche of Opisthorchis felineus vegetation.
Clinical case: second mandibular premolar with three root canals
Authors: Vusataya E. V. , Pomogalov R. G.
Published: July 2021

Successful and predictable endodontic treatment requires knowledge of root canal anatomy and morphology variations. In cases where X-ray images do not help to clarify the anatomy of the root canals, it is recommended to use magnifying devices. The second premolar of the lower jaw is one of the most diffcult teeth for endodontic treatment due to variations in internal morphology, additional root canals, apical deltas, and lateral canals. Diagnostic radiographs in different projections are important for getting an idea of the number of existing root canals. The purpose of root canal treatment is to clean the root canal of pathogenic microbes and infected pulp, prevent the formation of toxic products, and protect the periapical tissue. The presence of root canal variability increases the complexity of endodontic treatment. The complex anatomy of the root canals, the presence of additional channels, unnoticed by the dentist, can cause the failure of endodontic treatment.
Psychological assessment of the attitude to oral diseases of patients of older age groups who have applied for dental care
Authors: Alekseeva A. A. , Lukina G. I. , Glatkov I. S. , Lukin A. V.
Published: July 2021

Aim. Determination of the psychological type of attitude to the patient's illness, depending on gender and age group, which will further improve communication between the patient and the dentist.

Materials and methods. This article provides a psychological assessment of patients in relation to diseases of the oral cavity at a dental appointment using the adapted TOBOL technique. This technique is based on typing patients according to certain cognitive characteristics described in the article. For this study, 65 people of older age groups were interviewed.

Results. The frst group of attitudes towards the disease included 27 patients (41.5%), the second – 24 (37%), the third – 14 (21.5%). 11 (45.8%) men were assigned to the frst group, 8 (33.3%) men – to the second and 5 (20.9%) – to the third group. Women showed a distribution: 16 (39%) women belonged to the frst group, 16 (39%) – to the second and 9 (22%) – to the third group, respectively. Negative attitude towards dental diseases, reluctance to treat them sharply increases in centenarians.

Conclusions. With increasing age, there is a growing tendency towards pessimization and aggression. Sensitized attitudes toward illness, depression, refusal of treatment, or blame-shifting complicate diagnosis and subsequent treatment. To prevent unwanted emotions and improve the quality of communication, the dentist should be guided by an individual approach to these patients, which should be based on the basic principles of ethics and deontology. Only then will dental treatment be effective and complete.
Comparison of variability in diameter and taper of gutta percha cones of diﬀerent brands using Stereomicroscopy and Digital Micrometer
Authors: Mishra N. , Magwa K. , Agarwal M. , Singh M. P. , Singh S. , Thakur S.
Published: July 2021

Aim:Variations in cone tip diameter while obturation can lead to premature binding, extrusion, or poor adaptability of GP to the canal walls and promotes microleakage and ultimately endodontic failure. The purpose of this investigation was to measure the variability from the listed cone tip diameter and taper of size #25, 0.06 taper GP cones from three different brands with the help of stereomicroscope and digital micrometer.

Materials and methods:45 GP points (N = 45) of Size #25 with an 0.06 taper from three different brands were divided into three groups: Group A – Diadent Group B – K3 and Group C Pro- Taper Next. Each group have 15 GP (n = 15). The diameters (D0 and D3), tapers were measured according to the ANSI/ADA Specification No. 78 using stereomicroscope (accuracy of 0.001mm) and digital micrometer. Kruskall Wallis test was to detect any significant differences between two or more groups and Mann Whitney U test for pairwise comparison. p value < 0.05 were considered as statistically significant.

Results:On comparing there was significant variability within the three brands using stereomicroscopy, the standard values for D0 diameter which was 0.25 ± 0.23, Protaper Next GP cones was the similar to the standardized values compared to Diadent and K3 GP cones which were significantly different from the standard values. On comparing diameter variation at D3, Protaper Next, 0.043 ± 0.018 was once again similar to its manufacturer standard values of 0.43 ± 0.022. Diadent showed mild variation with D3 Diameter of 0.44 ± 0.017 and K3 was significantly different from the standard values K3 was 0.41 ± 0.018.

Conclusions:The results of the current study indicate significant variability between GP cone brands for both diameter and taper. However, the high standard deviation values associated with most of the diameter and taper differences from manufacturer’s nominal values also suggests high variability within individual brands.
Implementation of the Saving Matrix Method to Determine Vehicle Routes
Authors: Rizkilah Ramdani Willy , Rizwan Rifan , Faisal Khobir Muhammad , Fauzi Muchammad
Published: July 2021

The availability of the number of vehicles in Karawang Regency is not matched by the availability of fuel at gas stations. Due to the very high demand for fuel, the Cikampek BBM Terminal has several problems, including the absence of a standard distribution route in distributing its products to gas stations so that it takes a long time and the high amount of transportation costs that must be borne by the company. In this study, the route and distribution schedule will be determined as well as determining the capacity and number of tanker trucks that are able to minimize mileage, travel time and transportation costs. Based on calculations using the Saving Matrix method, it produces efficiency in the number of vehicles needed from 7 trucks to 4 tanker trucks, vehicle usage from 9 times to 6 times, distance traveled from 63 KM to 53 KM and the difference in transportation costs per day is Rp. 1,312,633.
Pengaruh Kebijakan Pembatasan Sosial Berskala Besar (PSBB) Terhadap Kinerja Penyuluh Pertanian di Provinsi DKI Jakarta
Authors: Ayu Puspita Sari  , Sugihardjo  , Widiyanto
Published: July 2021

Abstrak: COVID-19 pertama kali ditetapkan sebagai pandemi oleh WHO pada Februari 2020 dan setidaknya sudah menyebar ke 124 negara di dunia. COVID-19 masuk ke Indonesia pada 2 Maret 2020, kemudian menyebar luas di hampir seluruh wilayah Indonesia. Pandemi COVID-19 yang terjadi di Indonesia diprediksi akan mempengaruhi eksistensi sektor pertanian apabila perkembangannya semakin meluas. Penelitian ini bertujuan untuk (1) Menganalisis kinerja penyuluh pertanian di Provinsi DKI Jakarta selama diberlakukannya PSBB; (2) Mengetahui faktor-faktor yang dapat mempengaruhi kinerja penyuluh pertanian di Provinsi DKI Jakarta selama diberlakukannya PSBB; (3) Mengetahui pengaruh antara faktor internal dan eksternal penyuluh pertanian terhadap kinerja penyuluh pertanian selama diberlakukannya PSBB. Metode yang digunakan dalam penelitian adalah metode kuantitatif dengan eksplanatori. Lokasi penelitian ditentukan secara sengaja (purposive) yaitu di Provinsi DKI Jakarta. Metode pengambilan sampel ditentukan dengan teknik sensus. Analisis data yang dilakukan pada penelitian ini adalah dengan menggunakan analisis deskriptif dan uji regresi linear berganda. Hasil penelitian menunjukan bahwa kinerja penyuluh pertanian di Provinsi DKI Jakarta selama diberlakukannya PSBB berada pada kategori baik dengan pelaksanaan dalam kategori cukup dan evaluasi dan pelaporan dalam kategori sangat baik. Kinerja penyuluh pertanian Provinsi DKI Jakarta dipengaruhi oleh umur, masa kerja, pendidikan, pelatihan, ketersediaan sarana prasarana, dan kondisi lingkungan kerja sebesar 52,5%.
Machine Learning Algorithms Performance Analysis for VLSI IC Design
Authors: Chen Joy Iong-Zong , Lai Kong-Long
Published: July 2021

The design of an analogue IC layout is a time-consuming and manual process. Despite several studies in the sector, some geometric restrictions have resulted in disadvantages in the process of automated analogue IC layout design. As a result, analogue design has a performance lag when compared to manual design. This prevents the deployment of a large range of automated tools. With the recent technical developments, this challenge is resolved using machine learning techniques. This study investigates performance-driven placement in the VLSI IC design process, as well as analogue IC performance prediction by utilizing various machine learning approaches. Further, several amplifier designs are simulated. From the simulation results, it is evident that, when compared to the manual layout, an improved performance is obtained by using the proposed approach.
Storicità Il pataffio di Luigi Malerba, tra e attualità.
Una società in crisi e la lotta di classe
Authors: Issa Fawzi Mohamad
Published: July 2021

This study aims to analyze Luigi Malerba's novel Il pataffio, from a new perspective, namely that of its double value between historicity and actuality. Despite being set in the Middle Ages, the work reflects not only the social and political reality experienced and perceived by the writer in Italy in the sixties and seventies, but also reflects the contemporary one in other parts of the world. The novel is therefore nothing more than a denunciation of the multiform crisis of numerous contemporary societies where values are lacking, and where evil dominates in all its forms. By analyzing the plot of the work and the development of its story we will try to outline the traits of totalitarian regimes and highlight the catastrophic consequences of absolutism. The study will also highlight the similarity of the class struggle in the novel and the conditions experienced by some peoples under totalitarian regimes, especially in the countries of the Arab Spring, where the rebellion of the peoples and their revolution against the tyrants were the protagonist of the scene in the last few years.
СОВРЕМЕННЫЕ ПРОБЛЕМЫ ГЛОБАЛЬНОЙ ЭКОНОМИКИ
Authors: Куразова Д.А. , Тагиров Р.Б.
Published: July 2021

Целью данной статьи является анализ основных элементов нынешнего процесса экономической глобализации. Последствия этих элементов требуют ряда критических замечаний и предложений в отношении того, как местные органы власти должны справляться с глобализацией и какова должна быть роль международных учреждений в качестве инструментов, способствующих интеграции в мировую экономику, особенно наименее развитых стран. Цель этого исследования состоит в том, чтобы эмпирически определить позитивные и негативные последствия экономической глобализации для национальных обществ с тем, чтобы можно было выработать более эффективную государственную политику, которая позволит создать альтернативу глобальному управлению и быстро адаптироваться к глобальной интеграции.
Mechanisms of itch in atopic dermatitis
Authors: Grebenchenko E I , Gushchin KS , Fedenko E S , Grebenchenko E I , Gushchin I S , Fedenko E S
Published: July 2021

Pruritus is a constant and principal symptom of atopic dermatitis (AD), because of it's impact on quality of life. There fore studying of itch mechanisms is actual and could substantiate the ways of AD management. The present review is devoted to consideration of the modern data on this problem.
MECHANISMS OF FOOD ALLERGY CROSS-REACTIVITY FORMING: RESULTS OF RECENT STUDIES
Authors: Fedorova Ol'ga Sergeevna , Ogorodova L M , Fedorova O S , Ogorodova L M
Published: July 2021

The phenomenon of food allergy cross:reactivity presents significant interest for investigators and health care
specialists. This review provides an analysis of studies results of clinical features and manifestations mechanisms
of cross:reactivity. There are information about the food allergens main classes, estimation of sensitivity of
cross:reactivity different diagnostic methods, and principles of elimination diet in the article.
ALLERGENS AND «HIDDEN» ALLERGENS. WHAT IS THE DIFFERENCE?
Authors: Luss Lyudmila Vasil'evna , Repina T Yu , Tuzlukova E B , Luss L V , Repina T Ju , Tuzlukova E B
Published: July 2021

There is an increasing of allergic reactions on the so called «hidden» allergens during the last years. Nowadays a lot of allergens and various compositions could be regarded as the so called «hidden» allergens. At the same time their role in adverse reactions as well as in allergic reactions is not clear. This review is devoted to definition, classification and clinical contribution of «hidden» allergens. The allergic reaction to «hidden» allergen in genferon preparation is described as a clinical example.
IMPACT OF ENVIRONMENTAL POLLUTION ON THE PREVALENCE OF ALLERGIC DISEASES AMONG THE EMPLOYEES OF INDUSTRIAL SITES LOCATED AT FORMER URANIUM ORES MINES
Authors: Ilina N I , Luss L V , Martynov A I , Tsarev S V , Astafurov V I , Sidorovich O I , Martynov-Radushinski A A , Nazarova E V , Shartanova N V
Published: July 2021

The article presents the study of prevalence of allergic diseases among the employees of industrial sites located at former uranium ores mines in Lermontov region. The aim of the research was to study the spectrum of etiologically significant allergens, prevalence and clinical features of allergic diseases among the employees of industrial sites located at former uranium ores mines in Lermontov region. Materials and Methods. Analysis of data of screening questioning, clinical laboratory, functional and allergological methods of examination was performed. Results. The high prevalence of allergic diseases among employees of hydrometallurgical plant (OJSC GMP) and electromechanical plant (LLC EMP): 27,1 and 24,7%, respectively was found. Two employees of OJSC GMP and one of LLC EMPin 2014 had latent sensitization to pollen, but in 2015 demonstrated severe clinical symptoms of allergic rhinitis (AR). Conclusion. Respiratory forms of Ig-Emediated allergy - AR, bronchial asthma (BA) prevailed in the structure of allergic diseases among the employees of industrial sites located at former uranium ores mines in Lermontov region. 19,6% of OJSC GMP and 16,4% of LLC EMP employees showed an increased level of total IgE in the blood serum. No correlation between the increased total IgE and the presence of allergic deseases was established. These results can be explained by the weakening of the T-suppressor inhibitory mechanism that promotes IgE synthesis in response to antigenic stimulation (allergens, chemical factors, etc.).
ELIMINATION MEASURES AND SKIN CARE AS IMPORTANT STAGES IN PREVENTION OF EXACERBATIONS OF ATOPIC DERMATITIS IN CHILDREN
Authors: Gushchin P I , Chuvirov D G
Published: July 2021

According to recent data, the pathogenetically significant condition for the onset of atopic dermatitis is increasing epidermal permeability barrier and, therefore, a primary step in the treatment and prevention of atopic dermatitis should be control over the skin condition. Effective use of modern methods of prevention of exacerbations helps to reduce the frequency of relapses, lengthen the periods of remissions and, in general, improve the quality of life of sick children.
Allergen-specific immunotherapy. Analytic review of current international and Russian federal position papers
Authors: Kurbacheva O M , Pavlova K S , Galitzkaya M A
Published: July 2021

The article analyses the international position papers devoted to allergen-specific immunotherapy published in recent years. It also describes in details Russian federal guidelines, published in the 2013-2016 years and dedicated to allergen-specific immunotherapy as a method of treatment of IgE-mediated allergic diseases, as well as Russian federal guidelines. Detailed understanding of indications, contraindications, and usage of AIT in various clinical situations are widely discussed.
Prevalence and risk factors of asthma-like symptoms and allergic diseases in preschool children
Authors: Shakhova N V , Kamaltynova E M , Lobanov U F , Ardatova T S , Nikolaeva K S , Surcova M V , Nevskaya O V
Published: July 2021

Objectives. To estimate the prevalence of current asthma-like symptoms and current allergic diseases among preschool children and to determine the risk factors. Materials and methods. Cross-sectional study included children aged 3-6 years. The study was conducted in 5 towns of Altai region. Prevalence of allergic diseases was assessed using the Russian version of the ISAAC questionnaire. Results. According to questionnaire the prevalence of current asthma-like symptoms was 11,1%, current allergic rhinoconjunctivitis - 7,5%, current atopic dermatitis -12,3%. Out of 3205 children asthma was diagnosed in 0,9%, allergic rhinoconjunctivitis - in 3%, atopic dermatitis - in 7,9%. Family history of allergic diseases increases risk of development of the current asthma-like symptoms twice (OR=2,11; 95% CI=1,66-2,68), current allergic rhinoconjunctivitis by 2,8 times (OR=2,85; 95% CI=2,16-3,75), current atopic dermatitis by 4,6 times (OR=4,62; 95% CI=3,69-5,77). The male sex increases risk of the development of current asthma-like symptoms by 2,6 times (OR=2,63; 95% CI=1,17-5,93), current allergic rhinoconjunctivitis by 1,3 times (OR=1,35; 95% CI=1,03-1,76), smoking of parents on the first year of life of the child increases risk of development of current asthma-like symptoms by 1,6 times (OR=1,61; 95% CI=1,15-2,24), breastfeeding duration less than 6 months increases the risk of development of current atopic dermatitis by 1,6 times (OR=1,62; 95% CI=1,26-2,09; p
Influence of obesity on the natural course of asthma. There are more questions than answers
Authors: Glushkova E F , Shartanova N V
Published: July 2021

Recent data about the influence of obesity on bronchial asthma natural course are represented in this article. There are different controversial data about interaction between these two multifactorial diseases. This problem is interested in many researchers working in the fields of endocrinology, therapy, pulmonology, allerglogy, genetics. Nevertheless this interest doesn’t give any clues to many questions coming from scientists.
Intranasal steroids in treatment of allergic rhinitis
Authors: Kurbacheva O M , Shwets S M
Published: July 2021

Allergic rhinitis (AR) is one of the most common diseases affecting adults and children. AR is often a part of a systemic inflammatory process associated with other inflammatory conditions, including allergic conjunctivitis (Ac), rhinosinusitis and asthma. Undertreated AR impairs quality of life, exacerbates asthma and is a major factor in asthma development. There is a strong recommendation that clinicians recommend intranasal steroids (INS) for patients with a clinical diagnosis of AR whose symptoms affect their quality of life. All modern INS are minimally bioavailable and similar with regard to efficacy and safety at the recommended starting dose. however, differences in patient preference and safety of use during pregnancy may contribute to primary care physicians’ selection of an INS therapy for their patients.
Russian experience of refractory chronic urticaria treatment with omalizumab
Authors: Danilycheva I V , Elisyutina O G , Ilina N I , Latysheva E A , Latysheva T V , Fedenko E S , Shulzhenko A E
Published: July 2021

Background. To study the efficacy and safety of omalizumab in patients with chronic urticaria, refractory to antihistamines in clinical practice. Methods. In this retrospective clinical analysis, we assessed effectiveness, time to relief of symptoms, dose change after omalizumab administration, and safety in 17 CU patients, 16 with chronic spontaneous urticaria (CSU), 1 with different forms of chronic inducible urticaria (CindU) and 4 with both. Results. Treatment with omalizumab showed excellent effect in 70,6%, significant - in 17,7%, no effect - in 11,7% of CU patients. Eight patients marked effect for 24 hours, 2 - within 2-3 days, 2 - during 2 weeks, 1 - 4 weeks, and 2 patients - for 8 weeks. Eleven patients were receiving omalizumab 300 mg once per 4 weeks, one patient - 150 mg, 4 patients 2 injections of 300 mg, followed by 150 mg of 2, one patient had started treatment with a dose of 150 mg, continued treatment with omalizumab 300 mg. Omalizumab was safe. There was no influence of baseline total IgE levels and the results of test with autosera on the efficacy of omalizumab treatment. Conclusion. Our observation of patients with chronic spontaneous urticaria, with the concomitant or separate physical (induced) hives can resume high efficacy and safety of omalizumab treatment which can be recommended for CU patients, torpid to the first and secondline therapy.
Markers of endothelial dysfunction in bronchial asthma patients
Authors: De Silva N M , Nemtsov V I , Trofimov V I
Published: July 2021

Objective. To identify endothelial dysfunction (ED) in patients with bronchial asthma (BA) in the acute phase, to establish the relationship between levels of homocysteine (HC) and endothelin-1 (ET-1) in the blood, and the causes of the disease. Materials and methods. 32 young patients in acute phases of bronchial asthma divided into three groups depending on the cause of bronchial asthma, and 10 healthy individuals were included in the study. Respiratory function assessed by spirometry with bronchodilatation test, serum endothelin-1 level was determined with immunofermental analysis, homocysteine level was determined with plasma liquid chromatography method. The results. There was a significant statistical difference between groups in terms of homocysteine, endothelin-1 levels in blood. Significant positive correlation between the levels of homocysteine and endothelin-1 in patients with allergic bronchial asthma and a significant negative correlation between the marker levels of endothelial dysfunction and lung function were identified. Conclusion. Acute phase of asthma accompanied by endothelial dysfunction, characterized by different levels of homocysteine and endothelin-1 in blood, depending on the genesis of the disease.