bluuebunny/crossref_metadata_2025 huggingface dataset:
Javier Sicilia: Advocate of deliberative democracy in the Americas
Authors: Rathbun Lyon
Published: April 2019

When Javier Sicilia’s son was killed by cartel assassins in 2011, he transformed into a civic activist, with a mass following sufficiently large for Time Magazine to recognize him in 2011 as one of its “Protestors of the Year.” His very success mobilizing public opinion against cartel violence overshadows his more fundamental role as an advocate for deliberative democracy in the Americas. Sicilia’s historical importance lies in his recognition that only civic dialogue within the transnational public sphere that includes Mexico and the United States can heal the social pathologies unleashed by globalization and by the war on drugs. His ultimate achievement has been to dramatize what would be required of citizens to realize the democratic ideals that both countries profess as the foundations of their national identities.
The importance of “disclosure” in relationships between physicians and pharmaceutical companies
Authors: Makowska Marta , Jasiński Łukasz
Published: April 2019

The article raises issues of transparency in relationships between doctors and drug manufacturers. It indicates how important it is as a way for physicians and the pharmaceutical industry to regain public trust. The manuscript will define the concept of disclosure. It will discuss in detail The Physician Payment Sunshine Act from the U.S., which imposes a legal obligation on pharmaceutical companies to disclose their relationships with doctors and university hospitals. The article will also show the diverse regulation of disclosure in different countries of the European Union. The situation in Poland will be also described. In the summary, there will be a discussion about the importance of disclosure for patients and the advantages and disadvantages of such regulations for physicians and drug manufacturers.
Españoles tras las alambradas. Republicanos en los campos franceses, nazis y soviéticos (1939-1956) = Spaniards behind Barbed Wire. Republicans in the French, Nazi and Soviet camps (1939-1956)
Authors: Iordache Cârstea Luiza
Published: April 2019

Resumen: En un destino común, muchos republicanos españoles fueron víctimas de políticas de rechazo, exclusión, persecución, violencia y castigo en calidad de extranjeros «indeseables», «opositores», «rojos», «enemigos» o candidatos a serlo en regímenes democráticos y «totalitarios», concretamente en la Tercera República francesa, la Alemania nazi y la URSS estalinista. Como consecuencia de esas políticas, además de las coyunturas europeas y los contextos políticos, sociales y económicos de aquellos países, miles y miles de españoles fueron internados, deportados y recluidos en campos franceses, nazis y soviéticos. Partiendo de la experiencia compartida del exilio y del internamiento, el presente texto analiza el vía crucis de los españoles en aquellos sistemas concentracionarios y refleja las características comunes y singulares de esos desde una perspectiva comparada. Palabras clave: Exilio, campos de concentración, Francia, Alemania, URSS.Abstract: In a common destiny, many Spanish Republicans were victims of policies of rejection, exclusion, persecution, violence and punishment as «undesirable» foreigners, «opponents», «reds», «enemies» or candidates to be in democratic regimes and «totalitarian» ones, specifically in the Third French Republic, Nazi Germany and the USSR under Stalin. As a result of these policies, besides the European circumstances and the political, social and economic context of those countries, thousand and thousand Spaniards were interned, deported and detained in French, Nazi and Soviet camps. Based on the shared experience of exile and internment, the article analyzes the vía crucis of the Spaniards in those concentracionary systems and reflects the common and unique characteristics of those from a comparative approach.   Keywords: Exile, concentration camps, France, Third Reich, USSR.
INFLUENCING OF PROJECT-BASED LEARNING MODEL TOWARD SCIENCE PROCESS SKILLS ON ENVIRONMENT MANAGEMENT MATERIAL
Authors: Nawawi Sulton , Amilda Amilda , Sari Maya Puspita
Published: April 2019

This study aims to determine the effect of the application of Project Based Learning Model to Skill of Science Process on Environmental Management Material. This research design uses posttest-only control design with Quasi-Experimental method (quasi-experiment). The sample of this research is 35 students. Based on the results of the analysis of students' science process skills show that the implementation of learning using the model of Project Based Learning is better than the conventional learning model. This can be seen from the calculation of the test-t skills of the science process shows for sig tcount 0.000 <0,05, then Ha accepted and H0 rejected. The result of analysis of the average score of mastery of experimental science process skill class achieves 2.87 with good criteria while the students 'science process skill in control class 1.73 is sufficient to mean that the students' experimental class science process skill is higher than the control class science process skill. Thus, it can be concluded that the model of Project Based Learning affects the Skills of Science Process on Environmental Management Material.

Keywords: project based learning model; skills of science process.
INVESTIGATION OF THE MISCONCEPTION IN NEWTON II LAW
Authors: Kurniawan Yudi
Published: April 2019

This study aims to provide a comprehensive description of the level of the number of students who have misconceptions about Newton's II Law. This research is located at one State Junior High School in Kab. Pandeglang. The purposive sampling was considering used in this study because it is important to distinguish students who do not know the concept of students who experience misconception. Data were collected using a three tier-test diagnostic test and analyzed descriptively quantitatively. The results showed that the level of misconception was in the two categories of high and medium levels. It needs an innovative teaching technique for subsequent research to treat Newton's Newton misconception.
COMPASS: a COMprehensive Platform for smAll RNA-Seq data analySis
Authors: Li Jiang , Kho Alvin T. , Chase Robert P. , Pantano-Rubino Lorena , Farnam Leanna , Amr Sami S. , Tantisira Kelan G.
Published: April 2019

Background

Circulating RNAs are potential disease biomarkers and their function is being actively investigated. Next generation sequencing (NGS) is a common means to interrogate the small RNA'ome or the full spectrum of small RNAs (<200 nucleotide length) of a biological system. A pivotal problem in NGS based small RNA analysis is identifying and quantifying the small RNA'ome constituent components. Most existing NGS data analysis tools focus on the microRNA component and a few other small RNA types like piRNA, snRNA and snoRNA. A comprehensive platform is needed to interrogate the full small RNA'ome, a prerequisite for down-stream data analysis.

Results

We present COMPASS, a comprehensive modular stand-alone platform for identifying and quantifying small RNAs from small RNA sequencing data. COMPASS contains prebuilt customizable standard RNA databases and sequence processing tools to enable turnkey basic small RNA analysis. We evaluated COMPASS against comparable existing tools on small RNA sequencing data set from serum samples of 12 healthy human controls, and COMPASS identified a greater diversity and abundance of small RNA molecules.

Conclusion

COMPASS is modular, stand-alone and integrates multiple customizable RNA databases and sequence processing tool and is distributed under the GNU General Public License free to non-commercial registered users at https://regepi.bwh.harvard.edu/circurna/ and the source code is available at https://github.com/cougarlj/COMPASS.
DNA barcoding evidence for the North American presence of alfalfa cyst nematode, Heterodera medicaginis
Authors: Powers Thomas , Skantar Andrea , Harris Tim , Higgins Rebecca , Mullin Peter , Hafez Saad , Handoo Zafar , Todd Tim , Powers Kirsten
Published: April 2019

Specimens of Heterodera have been collected from alfalfa fields in Kearny County, Kansas & Carbon County, Montana. DNA barcoding with the COI mitochondrial gene indicate that the species is not Heterodera glycines, soybean cyst nematode, H. schachtii, sugar beet cyst nematode, or H. trifolii, clover cyst nematode. Maximum likelihood phylogenetic trees show that the alfalfa specimens form a sister clade most closely related to H. glycines, with a 4.7% mean pairwise sequence divergence across the 862 nucleotides of the COI marker. Morphological analyses of juveniles and cysts conform to the measurements of H. medicaginis, the alfalfa cyst nematode originally described from the USSR in 1971. Initial host testing demonstrated that the nematode reproduced on alfalfa, but not on soybeans, tomato, or corn. Collectively, the evidence suggests that this finding represents the first record of H. medicaginis in North America. Definitive confirmation of this diagnosis would require COI sequence of eastern European isolates of this species.
Ground‐Truthing a Recent Report of Cover Crop–Induced Winter Warming
Authors: Hunter Mitchell C. , White Charles M. , Kaye Jason P. , Kemanian Armen R.
Published: April 2019

Core Ideas

It was recently reported that cover crops could raise winter temperature up to 3°C.

Agronomic context and measured cover crop morphology indicate this is unlikely.

The most realistic cover crop scenario did not cause significant local warming.

Winter cover crops remain a potential tool for climate mitigation.

Winter cover crops have been proposed as a potential climate mitigation practice, but a recent study concluded that cover crops may increase local temperature by up to 3°C. Here, we present agronomic context and data on cover crop morphology to ground‐truth the scenarios simulated in this study. We conclude that the scenario of cover crop morphology on which the study's headline claim is based is unlikely to be found in contemporary production systems. The most realistic scenario simulated did not result in significant local warming. Therefore, we argue that widespread planting of cover crops is unlikely to substantially increase local winter temperatures.
Obstacles of human resource planning that affect workers in delivering quality services
Authors: Khumalo Njabulo
Published: April 2019

The paper aimed to identify the obstacles of Human Resource Planning (HRP) that affect workers in delivering quality services to public within the customer centres of the municipality located in South Africa (SA). Since, HRP is well known as a tool that resolves the existing and future organization obstacles by confirming that the right employees are placed in the right positions at the right time. The investigation of the paper used mixed methods, which encompasses both qualitative and quantitative methods in its data collection. From the target, only 45 workers completed a questionnaire and only seven supervisors participated in one-on-one interviews. Results reveal the lack of both internal and external factors, which include a shortage of workers to perform the duties of the municipal in the customer centres. This includes demographic issues, lack of education qualifications, recruitment policies, insufficient working tools, working environment and career growth. The recommendation is to implement a strategical recognition for good performance to workers and to look for other venues with enough space to deliver quality services. Lastly, there is a need to establish and implement strategies of promotion and growth within the municipality.
Facebook in an English Guided Self Learning Class
Authors: Wiannastiti Melania
Published: April 2019

The use of technology especially the Internet in language teaching and learning has become more popular nowadays since it is more interesting and effective. Nowadays, since almost every person has at least a gadget connected to the Internet, the teaching learning is possible to be carried out outside the classroom in the way of autonomous learning. Language learners are likely to look to computers and the Internet for resources of learning. By applying the Internet as the type of learning, students are exposed to optimize the use their gadget connected to the Internet. This type of learning was also applied for Binus pre-university students learning English Smart Program in GSLC (Guided Self Learning Class). Based on the background, this paper aims to explain what GSLC is and describe how Facebook as the Internet social media can be used for supporting GSLC. There are many advantages the students and the lecturer get from using this media in GSLC. From result of the questionnaire, FB is affective to support them in learning.  In conclusion, Facebook can be used to support the GSLC activities.
Kepemimpinan: Usaha Pemberdayaan Pemimpin Baru Menuju Pertumbuhan Organisasi Berkelanjutan
Authors: Ismoyo Thomas Ulun
Published: April 2019

“Leadership is the capacity and the willingness to rally men and women to a common purpose. But it also a character which inspires confidence.” These are the words uttered by Bernard Montgomery, a British Field Marshal, when asked what leadership meant to him. From his quote, he reveals the importance of the role of a leader in any organization. A leader will direct and at the same time emit confidence to his followers. In life, human beings are the main catalyst for the world’s living history. The same applies to any organization. Human is the most important agent that creates, develops and keeps the whole institution running smoothly. However not everyone is capable of leadership. One needs a competent characteristic and various qualifications to execute the role. The organization must first make an effort and sizeable attention to attract such personnel who can make a valuable contribution to the organization. One of the effort may be to establish a leadership development program. With the specific objective of producing more competent leaders, it needs special leader who can guide, influence, and develop people within the organization. Leadership development becomes a serious task for any organization because its fate and future lies on the capability of its new leaders. Leadership development in every organization is both personal and communal. Personal because there is an individual effort to progress and improve himself so that he will finally be trusted to lead in the organization. However this personal progression needs a support system and a structure that supports and facilitate every type of personality to become a dependable leader. This macro support system is communal in characteristic.
Hubungan Antara Self-Efficacy Akademik dan Konsep Diri Akademik dengan Prestasi Akademik
Authors: Chairiyati Lisa Ratriana
Published: April 2019

This study discusses the relationship between academic self-efficacy and academic self-concept with academic achievement. The design of the study was descriptive - correlational, with a study sample of 192 children. Statistical Analysis with SPSS computer method (Statistical Package for Social Science) version 17.0 for windows is used to find out characteristics of the respondents, and the regression analysis between the two independent variables (self-efficacy and academic self-concept academic) and the dependent variable (academic achievement) produce models regression . The results showed only variable Self-Efficacy (SE) contributes positively to academic achievement. It is supported by the value of t-statistic greater than 1, 645 for the value . Hence it can be said that the dependent variable (academic achievement) can be predicted with self-efficacy academic.
Pengembangan Alat Ukur Kepuasan Pernikahan Pasangan Urban
Authors: Rumondor Pingkan C. B.
Published: April 2019

The current study aims to validate the measure of marital satisfaction among young urban married couples. Marital satisfaction is defined as a individual’s subjective experience toward marriage or components within a marriage. The scale consists of 38 items measuring individual’s satisfaction in communication, division in roles, agreement, openness, intimacy, intimacy in social relationship, sexuality, finance, and spirituality. The results indicate that the instrument was found to be reliable (α= 0.920) and have low correlation with subjective rating of overall marital satisfaction (rs = 0.293, p < 0.05).
Mengupayakan Keluarga yang Harmonis
Authors: Tirtawinata Christofora Megawati
Published: April 2019

Harmonious family is the best environment for individuals to be able to shape a healthy personality. Healthy personality and healthy families are necessary in building a healthy society, which in turn is needed in building the nation. In fact many couples have not been able to seek a harmonious family so that they end their marriages in divorce. Causes of divorce in general are because there is no harmony. Article is based on the observation and study of literature. It describes the efforts to build harmony in the family, before marriage and during marriage. Therefore, the couple is able to understand the difference between them and respond positively and always communicate assertively.
Bagaimana Product Knowledge dan Product Involvement Memotivasi Konsumen? (Kajian Motivasi Masyarakat Terhadap Pemilihan Jurusan Komunikasi Pemasaran Universitas Bina Nusantara sebagai Tempat Melanjutkan Pendidikan Tinggi)
Authors: Damanik Elsye Rumondang
Published: April 2019

Consumers require knowledge and involvement upon consuming products/services. In order to find out the characteristics of the products/services, consumers perform certain efforts from searching information through the media, being directly involved by using the products/services, to asking questions to the products/services users. Consumers’ level of interest and ability in deciding which products/services they want to use also vary.  Consumers are highly influenced by product knowledge, and (personal) involvement with the chosen products/services. This research aims at understanding how characteristics of products/services and personal involvement motivate consumers in using the services of Jurusan Komunikasi Pemasaran Universitas Bina Nusantara. Using quantitative research approach, this research tried to understand the level of validity and reliability of research instrument, the efficiency of research instrument, and relationship among variables. The result showed that the research instrument is valid and reliabel. The reliability is stated from the Cronbach Alpha value of each variable (product knowledge = 0,877; product involvement = 0,734; motivation = 0,836).  The instrument is valid with Corrected Item-Total Correlation value of 0,148 (approx. df = N-2; or df = 164). It is concluded that consumers’ product knowledge and product involvement to Jurusan Komunikasi Pemasaran Universitas Bina Nusantara motivate the (future) students in putting it as the preferred place to have quality education. One of the suggestions is to invite more media practitioners during Open House Program since it will enable the (future) students to have better understanding on the communication related activities.
ANÁLISE DE ALTERNATIVAS PARA O DESENVOLVIMENTO DE PRODUTOS EM SISTEMAS DE INFORMAÇÕES PARA EMPRESA DO SETOR BANCÁRIO
Authors: Malanovicz Aline Vieira
Published: April 2019

O objetivo deste trabalho é analisar alternativas de remodelagem do processo de desenvolvimento de produto em uma empresa pública do setor financeiro. O processo atual, com seus problemas, e as alternativas de solução, com seus potenciais benefícios, são apresentados com base em entrevistas com desenvolvedores, análise de documentos e observação participante em alguns projetos. Conclui-se que as propostas apresentam contribuições para a organização estudada, indicando soluções para problemas identificados, e oferecendo desdobramentos para outras organizações na forma de oportunidades de melhorias para a eficiência e a sustentabilidade do processo de desenvolvimento de produtos. Podem ser destacados como benefícios potenciais da alternativa de remodelagem do processo: maior segurança e qualidade no desenvolvimento dos produtos, pela necessidade de definição de condições interconectadas no sistema integrado, e pela maior facilidade na realização de testes; maior clareza e legibilidade de documentação, pela parametrização pré-definida dos critérios de cálculo; maior eficiência e flexibilidade para o desenvolvimento de novos produtos, pela existência e pela variedade de condições pré-definidas que podem ser selecionadas e combinadas entre si para a composição de um novo produto; maior sustentabilidade do processo, pelas melhores condições de manutenção e testes, em consequência da segurança, clareza e flexibilidade alcançadas no novo processo.
Noty proweniencyjne i właściciele ksiąg biblioteki klasztoru cysterek w Trzebnicy w świetle inwentarza Heleny Szwejkowskiej
Authors: Zielonka Katarzyna
Published: April 2019

Many of the marks of ownership were included in the inventory of the Library of the Cistercian Monastery in Trzebnica. Owners and history of individual book are known to us thanks to the provenience notes which Helena Szwejkowska recorded in her catalogue. The author of the abovementioned work gathered all provenience notes into a few groups, which allowed us to see how the book collection was growing.That was possible because of buying books and people who decided to give their books to the monastery library. Although it was forbidden, a lot of nuns were in private possession of books and when they died their books become part of library in Trzebnica. Abbesses of the monastery in Trzebnica were also listed in Szwejkowska’s catalogue as book’s owners.By provenience notes we can also see the connections between the monastery in Trzebnica and other Cistercian monasteries in Polish-Lithuanian Commonwealth eg. Lubiąż, Jemielnica, Przemęt. Also there was an exchange of books between Trzebnica and it’s branch in Owińska.Many of the books were brought to Trzebnica by priests who were confessors and sermonizers to Cistercian nuns. There are evidences that some of the books were brought to the monastery in Trzebnica by Eugeniusz Lenga (who later was an abbot in Jemielnica) and Benedykt Cieszkont (who used to be the confessor in Trzebnica). Kasper from Przemęt has to be mentioned as the one who brought some of the manuscripts.A lot of highly valuable information can be read by historians from margin notes and other marks that were written on the pages of books in the library in Trzebnica. Especially important are provenience marks from the period of the dissolution of the monastery when all the precious books were removed from Trzebnica by Johann Gustaw Büsching.
Księgozbiór parafii we Wrzawach w świetle wizytacji generalnej z 1748 roku
Authors: Moskal Tomasz
Published: April 2019

The article presents the parish library in Wrzawy in 1748. Information about it was provided by the protocol of the general visitation of the archdeaconry of Zawichost in the diocese of Cracow, realized by the archdeacon of that time, Józef Cyprian Lange (+1757). The collection of 15 books had a typically pastoral character. Texts of the Holy Scriptures, homiletic works of Alexander Lorencowicz, Sebastian Stryjewicz, Jan Osorius, Didacus Nisenus theological-moral Jan Busaeus, Robert Bellarmine, Ludwik of Granada and ascetic Tomasz and Kempis, helped to work on the pulpit or in the confessional. Thus, although it was not a collection of books, it was varied in content.
Wytyczne hetmana Wacława Rzewuskiego (1706-1779) dla służby pałacowej. Przyczynek do funkcjonowania rezydencji podhoreckiej w połowie XVIII wieku
Authors: Paduch Katarzyna
Published: April 2019

From 1729 the Palace in Podhorce was the residence of Grand Crown Hetman Waclaw Rzewuski (1709-1779). Hetman arranged a magnificent Old Polish magnate residence in the Podhorecki palace, having souvenirs of representatives of the Sobieski family and the Koniecpolski family, as well as a gallery of works of art, an armory and a library. This article is an attempt to present the functioning of the Podhorce residence in the light of the guidance kept in the Book of inventory and instructions of the Podhorce castle from 1745-1754. Among the preserved guidelines, one can distinguish instructions concerning various areas of the functioning of the Podhorce residence, namely: welcoming guests, the kitchen and the table of residence, security, heating and lighting of the palace, as well as the Podhorce stables.
Dziatki miłe Elżbiety i Stanisława Kruszyńskich
Authors: Żołądź-Strzelczyk Dorota
Published: April 2019

The article uses source materials to present the situation of the family of Stanisław Kazimierz Kruszyński, a noble living with his relatives in Lower Łąkta in Lesser Poland. The sylwa stored in the collection of Ossolineum in Wroclaw, contains several messages about children. These are notes speaking of the birth of subsequent children, the place and circumstances of their baptism. We also have a poem written by a mother after the death of her youngest children. And above all same, recommendations for the education of sons to be found in the will and the supplement to it. They had to study at the Piarist college in Podoliniec and then practice at the office. These few preserved sources provide us with information about family life and attitudes towards children in the early 18th century.
Corona triumphalis – znaczenie i symbolika w starożytnym Rzymie
Authors: Karczewska Helena
Published: April 2019

The laurel wreath in ancient Rome was a symbol of victory. It was one of the greatest awards of military merits. Corona triumphalis had foremost sacral symbolism, which was influenced by the material from which it was made. Laurels were attributed to the purgatory properties, protecting the triumpher, his army, family and home against revenge from his opponent. The imposition of the laurel wreath probably served for both cleansing and protective functions. There were several types of coronae triumphalis. They were subject to meaning and symbolic changes that lasted until the period of the Roman Empire.
The Place of the Saint Ladislaus’ Monarchy in the Medieval Europe according to the Western Chroniclers at the time of the First Crusade
Authors: Dźwigała Bartłomiej
Published: April 2019

The present article examines the First Crusade’s passage through the Kingdom of Hungary. Basing on the two main narrative sources: the Historia Ierosolimitana of Albert of Aachen and the chronicle of the William of Tyre the author comments on the relationship between the king of Hungary, Coloman the Learned, and Western European crusaders, which is the starting point to discuss a wider problem of opinion on newly christianizeed Hungary from the post-Carolingian Europe’s point of view. As it has been shown, the Kingdom of Hungary at the time of the First Crusade was perceived as a member of Latin Christendom. Furthermore there is no evidence in contemporary Latin narrative sources for the chroniclers’ negative approach towards Hunagarian Monarchy.
Alginate Nanoparticles for Drug Delivery and Targeting
Authors: Severino Patricia , da Silva Classius F. , Andrade Luciana N. , de Lima Oliveira Daniele , Campos Joana , Souto Eliana B.
Published: April 2019

Nanotechnology refers to the control, manipulation, study and manufacture of structures and devices at the nanometer size range. The small size, customized surface, improved solubility and multi-functionality of nanoparticles will continue to create new biomedical applications, as nanoparticles allow to dominate stability, solubility and bioavailability, as well controlled release of drugs. The type of a nanoparticle, and its related chemical, physical and morphological properties influence its interaction with living cells, as well as determine the route of clearance and possible toxic effects. This field requires cross-disciplinary research and gives opportunities to design and develop multifunctional devices, which allow the diagnosis and treatment of devastating diseases. Over the past few decades, biodegradable polymers have been studied for the fabrication of drug delivery systems. There was extensive development of biodegradable polymeric nanoparticles for drug delivery and tissue engineering, in view of their applications in controlling the release of drugs, stabilizing labile molecules from degradation and site-specific drug targeting. The primary aim is to reduce dosing frequency and prolong the therapeutic outcomes. For this purpose, inert excipients should be selected, being biopolymers, e.g. sodium alginate, commonly used in controlled drug delivery. Nanoparticles composed of alginate (known as anionic polysaccharide widely distributed in the cell walls of brown algae which, when in contact with water, forms a viscous gum) have emerged as one of the most extensively characterized biomaterials used for drug delivery and targeting a set of administration routes. Their advantages include not only the versatile physicochemical properties, which allow chemical modifications for site-specific targeting but also their biocompatibility and biodegradation profiles, as well as mucoadhesiveness. Furthermore, mechanical strength, gelation, and cell affinity can be modulated by combining alginate nanoparticles with other polymers, surface tailoring using specific targeting moieties and by chemical or physical cross-linking. However, for every physicochemical modification in the macromolecule/ nanoparticles, a new toxicological profile may be obtained. In this paper, the different aspects related to the use of alginate nanoparticles for drug delivery and targeting have been revised, as well as how their toxicological profile will determine the therapeutic outcome of the drug delivery system.
Methods for Hydroxamic Acid Synthesis
Authors: Alam Mohammad A.
Published: April 2019

Substituted hydroxamic acid is one of the most extensively studied pharmacophores because of their ability to chelate biologically important metal ions to modulate various enzymes, such as HDACs, urease, metallopeptidase, and carbonic anhydrase. Syntheses and biological studies of various classes of hydroxamic acid derivatives have been reported in numerous research articles in recent years but this is the first review article dedicated to their synthetic methods and their application for the synthesis of these novel molecules. In this review article, commercially available reagents and preparation of hydroxylamine donating reagents have also been described.
Bisphosphonates and Cancer: A Relationship Beyond the Antiresorptive Effects
Authors: Teixeira Sonia , Branco Luis , Fernandes Maria H. , Costa-Rodrigues João
Published: April 2019

Bisphosphonates (BPs) are stable analogues of the Inorganic Pyrophosphate (PPi), an endogenous regulator of bone mineralization, which can resist the hydrolysis in the gastrointestinal tract. Their conformation allows targeting the bone as a result of their three-dimensional structure, which makes them primary agents against osteoclast-mediated bone loss. They are used in many bone pathological conditions, like bone metastasis, because of its ability to modulate bone metabolism into a less favorable place to cancer cell growth, through the inhibition of osteoclastogenesis and bone resorption. This review is focused on the mechanisms of action through which BPs affect the cellular activity and survival, mainly on their antitumoral effects. In conclusion, BPs are considered the primary therapy for skeletal disorders due to its high affinity for bone, but now they are also considered as potential antitumor agents due to its ability to induce tumor cell apoptosis, inhibition of cell adhesion, invasion and proliferation, modulation of the immune system to target and eliminate cancer cells as well as affect the angiogenic mechanisms. Like any other drug, they also have some adverse effects, but the most common, the acute phase reaction, can be minimized with the intake of calcium and vitamin D.
Real-World Clinical Effectiveness and Tolerability of Hydroxychloroquine 400 Mg in Uncontrolled Type 2 Diabetes Subjects who are not Willing to Initiate Insulin Therapy (HYQ-Real-World Study)
Authors: Gupta Amit
Published: April 2019

Objective:

The epidemic of T2DM is rising across the globe. Systemic inflammation plays a
pivotal role in the pathogenesis and complications of T2DM. Combination of two or more oral hypoglycemic
agents (OHA) is widely prescribed in patients with T2DM, however many patients have poor
glycemic control despite receiving combination therapy. The new antidiabetic drugs are relatively
costly or many patients have anxiety over the use of injectable insulin. The objective of this observational
study was to investigate the effectiveness and tolerability of hydroxychloroquine (HCQ) in
T2DM patients uncontrolled on multiple OHA and despite high sugar level not willing to initiate insulin
therapy in a real-world clinical setting.

Methods:

A prospective, investigator-initiated, observational, single-centred study was conducted
where 250 patients (18-65 years) with T2DM for more than 5 years, with uncontrolled glycemia despite
on a combination of multiple OHA, HbA1c between ≥7% and <10.5%, FPG >130 mg/dL or PPG >180
mg/dL and BMI between >25 and <39 kg/m2, were prescribed hydroxychloroquine sulphate 400 mg
once daily for 48 weeks. Percentage of drugs used at the baseline were as follows: metformin 2000 mg
(100%), glimepiride 4 mg (100%), pioglitazone 30 mg (100%), sitagliptin 100 mg (100%), canagliflozin
300 mg (52.4%), empagliflozin 25 mg (22.8%), dapagliflozin 10 mg (17.6%) and voglibose 0.3
mg (62%). Mean change in HbA1c, blood glucose and hs-CRP at baseline, week 12, 24 and 48 were
assessed using the paired t-test.

Results:

After 48 weeks of add-on treatment with HCQ, almost all SGLT-2 inhibitors were withdrawn;
metformin dose was reduced to 1000 mg, glimepiride reduced to 1 mg and sitagliptin reduced to 50 mg
OD. Patients continued to have good glycemic control. HbA1c was reduced from 8.83% to 6.44%. Reduction
in FPG was 40.78% (baseline 177.30 mg/dL) and PPG was reduced by 58.95% (baseline
329.86 mg/dL). Change in mean body weight was -4.66 Kg. The reduction in glycemic parameters and
mean body weight was significant (p < 0.0001). Hs-CRP was significantly reduced from 2.70±1.98
mg/L to 0.71±0.30 mg/L 9 (p < 0.0001). More reduction in glycemic parameters and body weight was
observed among the patients with higher hs-CRP (> 3 mg/L) as compared to patients with baseline hs-
CRP ≤ 3 mg/L. Most common adverse events reported with the drug therapy were GI irritation (3.6%)
and hypoglycemia (2%). None of the patients required medical assistance for hypoglycemia.

Conclusion:

Add-on treatment of HCQ effectively improved glycemic control in T2DM patients uncontrolled
on multiple antidiabetic drugs. By virtue of its antidiabetic and anti-inflammatory properties,
it may emerge as a valuable therapeutic intervention for the patients with T2DM.
La experiencia de B@UNAM en la atención de migrantes
Authors: Zuazua Mónica
Published: April 2019

El texto comparte algunos de los aprendizajes

generados desde la impartición del

Bachillerato a Distancia de la UNAM, B@

UNAM a hispanoparlantes que radican en el

extranjero. Busca dar a conocer las características,

problemática, motivaciones y expectativas

de esta población, así como los retos

que implica brindarle atención, destacando

la importancia y necesidad de que los bachilleratos

públicos a distancia en México les

ofrezca alternativas. Labor que sólo es posible

mediante un trabajo interinstitucional

que favorezca la visibilización y el prestigio

de la modalidad para lograr mayor cobertura

y atención al rezago educativo en el nivel

medio superior.
Migración de las TIC al salón de clase: perspectiva de comunicación en la educación
Authors: Torres Flores Sergio Guadalupe , Cavazos Salazar Rosario Lucero , Flores Michel Julieta
Published: April 2019

La propuesta está fundamentada en la necesidad de implementar un modelo educativo-comunicativo en donde se apliquen recursos digitales dentro de la dinámica del proceso enseñanza-aprendizaje, esto bajo un paradigma educativo (conectivismo) que se caracteriza por la forma de aprender bajo un enfoque constructivista. Si se considera objeto de estudio el proceso comunicativo se pretende obtener elementos para apoyar el planteamiento de un modelo educomunicativo en el que se pondera el uso de las tecnologías de la información y de la comunicación en el aula. Se utilizó como instrumento de captación un cuestionario con preguntas cerradas en la escala de Likert. Dicho instrumento fue aplicado a estudiantes de docencia (regulares) en modalidad presencial de nivel maestría. Todos los sujetos fueron considerados para contestar el cuestionario. La estrategia metodológica de investigación que se empleó fue de tipo cualitativo y de carácter descriptivo. Los resultados obtenidos dieron pauta para respaldar la propuesta de un nuevo modelo en los procesos de enseñanza-aprendizaje para los docentes que imparten sus cursos favoreciendo el aprendizaje significativo.
Hacia un Modelo de trabajo colegiado: experiencia en Bachillerato Universitario a Distancia de la UAEMéx
Authors: Vega- Mondragón Belem , Panchi-Vanegas Virgina Pilar
Published: April 2019

Este escrito explica de manera sucinta una propuesta para la conformación de cuerpos colegiados propios para el trabajo entre pares académicos en el Bachillerato Universitario Modalidad a Distancia de la Universidad Autónoma del Estado de México. 

Los momentos en los que se llevó a cabo la propuesta fueron dos: el primero se orientó al análisis de documentos normativos, curriculares, padrones de calidad educativa y autoevaluación, mientras que el segundo se relacionó con etapas para el desarrollo del modelo y su representación gráfica. 

El desarrollo de este modelo implicó considerar elementos que van desde los actores (pares académicos que conforman la planta docente del BUAD), los campos de formación curricular, las características del CBUAD, los programas educativos ofertados, la malla curricular y la relación entre las Tecnologías de la Información y la Comunicación y las Tecnologías de Aprendizaje Curricular; todo lo anterior debía ser conjugado en una dinámica integral dentro de un ambiente de aprendizaje virtual.
Um estudo da Teoria da Argumentação da Retórica Aristotélica à Teoria dos Blocos Semânticos
Authors: Sena Geane Cássia Alves , Figueiredo Maria Flávia
Published: April 2019

Este artigo tem como objetivo desenvolver um estudo teórico sobre a Teoria da Argumentação, iniciando pela Retórica aristotélica, perpassando pelo advento da Nova Retórica com Perelman & Olbrechts-Tyteca, até chegar à Teoria da Argumentação na Lí­ngua, proposta por Ducrot e colaboradores. Para atingir nosso propósito, realizamos uma pesquisa bibliográfica, apoiada nos estudos realizados por teóricos que discutem sobre a Retórica e a Nova Retórica, como Reboul (2004) e Perelman e Olbrechts-Tyteca (2005), e a Teoria da Argumentação na Lí­ngua, como Ducrot (1987). A partir dos estudos aqui apresentados, verificamos que a argumentação tem sido estudada por vários pesquisadores e de diversas áreas do conhecimento, inclusive da Linguí­stica. Ainda observamos que, segundo Ducrot e colaboradores, a argumentação está inscrita na própria lí­ngua e passa a ser concebida como uma atividade estruturante de qualquer discurso. Enfim, a argumentação tem sido objeto de estudo desde a antiga Grécia até os dias atuais.
No caminho da leitura literária ou com a leitura literária em seu caminho
Authors: Torres Maria Gorete Paulo , Sampaio Maria Lúcia Pessoa
Published: April 2019

Este trabalho é resultado de uma dissertação de mestrado na qual se identifica que textos literários são lidos por professoras do curso de Letras/Lí­ngua Portuguesa, de uma Universidade pública. Verifica-se ainda, com que finalidade e com frequência as professoras pesquisadas realizaram a leitura literária e como ocorreu esse processo. Como aporte teórico foram utilizados os estudos de Antunes (2009), Amarilha (1997 -2006), Magnani (2001), Machado (2002), Martins (2006), Sampaio (2005), dentre outros, que discutem sobre o processo de formação de leitores e a leitura por prazer. Trata-se de uma pesquisa qualitativa, além de se configurar como uma pesquisa descritiva e interpretativa. Caracteriza-se como uma pesquisa documental, pelo fato de se trabalhar com material escrito de primeira mão. Utiliza-se a indução como procedimento de análise o corpus se constituiu de depoimentos das professoras já mencionadas. Os resultados apontam que as professoras pesquisadas realizaram e/ou realizam leituras de uma grande diversidade de textos literários em uma frequência constante e que as professoras realizam a leitura literária com várias finalidades, tais como: para discussão e reflexão em sala de aula, para ajudar a compreender as teorias utilizadas em suas aulas e para sentirem prazer.
Reflexões sobre os impasses na relação entre professor de português e a leitura literária: uma discussão teórica
Authors: Silveira Paula Renata Hanke da
Published: April 2019

Neste trabalho, objetiva-se refletir acerca dos impasses presentes na relação entre o professor de português e a leitura literária. Para realizar tal intenção, a metodologia deste trabalho se dá por meio de uma discussão teórica utilizando diversos autores que abordam questões relativas à natureza e função do texto literário, conceito de leitura e leitor, além do modo pelo qual se busca trabalhar estes textos em sala de aula. Abordam-se também os impasses suscitados pela relação entre professor de português e texto literário. Nota-se que estes impasses vividos pelo professor de português no que diz respeito ao texto literário são dois: o equilí­brio entre natureza inconstante da literatura e burocracia escolar; possí­vel formação leitora insuficiente do professor como leitor que o leva a assumir uma postura mimética quanto ao uso do texto literário em sala de aula.
Contribuições das teorias do texto e do discurso para o ensino-aprendizagem de lí­nguas estrangeiras: uma entrevista com Lí­via Márcia Tiba Rádis Baptista
Authors: Carvalho Tatiana Lourenço de , Irineu Lucineudo Machado , Carmona Esther Casares
Published: April 2019

Neste volume da revista Diálogo das Letras, os professores Tatiana Lourenço de Carvalho  (UERN / USAL), Lucineudo Machado Irineu  (UERN) e Esther Casares Carmona  (USAL) apresentam uma entrevista realizada com a professora Dra. Lí­via Márcia Tiba Rádis Baptista, do Programa de Pós-Graduação em Linguí­stica da Universidade Federal do Ceará (UFC). Lí­via Baptista é um dos principais nomes do paí­s em estudos aplicados ao ensino de lí­nguas estrangeiras, mais especificamente ao ensino de lí­ngua espanhola em contexto brasileiro. Atualmente, Baptista é professora associada I da Universidade Federal do Ceará, com experiência de pesquisas na área de Linguí­stica, com ênfase em Linguí­stica Aplicada, atuando principalmente nos seguintes temas: ensino e aprendizagem de lí­nguas (português e espanhol), formação de professores, análise de discurso crí­tica, representações, multiletramentos e tecnologia educacional. Orienta pesquisas em ní­vel de iniciação cientí­fica, mestrado e doutorado. É lí­der do Grupo de Pesquisa Ensino e Aprendizagem de Lí­nguas Adicionais (GEALA/CNPq) e integrante do GT da ANPOLL Ensino e aprendizagem na perspectiva da Linguí­stica Aplicada.
A escrita do pesquisador, tecituras filosóficas e cientí­ficas: entre devires e devaneios
Authors: Abud Cristiane Ramos , Teive Gladys Mary G.
Published: April 2019

Este texto é um convite a pesquisadores, filósofos, escritores, leitores, para dar pistas de que é possí­vel traçar outros olhares sob os objetos de pesquisa, tecendo análises, experimentações, aproximações interdisciplinares, para que se formulem outras interrogações, seja inventando, brincando, com diferentes modos de análise da linguagem e suas investigações. Com o auxí­lio do personagem Zaratustra de Nietszche que percorre o texto, pretende-se ressignificar o conceito de linguagem como potência criadora da escrita, constituí­da nas relações de poder históricas e transitórias. Sugerindo, ainda, a bricolagem (KINCHELOE, 2007) como campo de estudo, onde a interdisciplinaridade seria a peça de tecido, recortada em inúmeros pedaços, e a pesquisa seria a costura, as redes formadas pelos retalhos, resultando numa colcha que nunca será novamente o mesmo tecido de outrora; ou seja, sempre abrindo novos caminhos para a investigação e a interpretação. Uma das tarefas essenciais do pesquisador é a de abrir caminhos, modificar e alterar as estruturas e hierarquias que regem a produção dos conhecimentos cientí­ficos dados como limí­trofes e inquestionáveis.
A produção de texto na perspectiva da escrita criativa
Authors: Rodrigues Flávio Luis Freire
Published: April 2019

A Escrita Criativa (Creative Writing), desde o século XIX, tem sido usada como escola para escritores, mas pouco conhecida e explorada no Brasil. A base desta metodologia está na análise e discussão de textos literários, seguida da produção, discussão e revisão textual. São necessários suportes da teoria e crí­tica literária e conhecimento textual. A maioria das referências está em inglês, mas o que talvez seja empecilho maior para a aceitação da sua metodologia no Brasil no âmbito acadêmico é que os manuais são apresentados em uma linguagem formal, porém, não acadêmica, o que pode dar a impressão de caráter pouco cientí­fico. Mesmo assim, julgamos que a proposta pode auxiliar no trabalho do ensino de textos.
A(s) concepção(ões) de linguagem que norteia(m) as práticas discursivas nas aulas de lí­ngua portuguesa do ensino médio
Authors: Rebouças José Válter , Costa Mikaeli Cristina Macêdo , Pontes Antônio Luciano
Published: April 2019

Este trabalho propôs-se a analisar que tipo de concepção de linguagem norteia as práticas discursivas nas aulas de Lí­ngua Portuguesa do Ensino Médio e de que forma isso influencia na proficiência leitora dos alunos. Além disso, procurou-se analisar se essas propostas contemplam a inserção da diversidade de gêneros textuais como elementos de grande importância para a interação sociocognitiva dos alunos em ambientes fí­sicos e virtuais. Para tanto, metodologicamente, norteou-se, a partir da prática docente, observando questões como: De que maneira a leitura é trabalhada na prática discursiva em sala de aula? A proposta discursiva contempla a diversidade de gêneros textuais? Na análise dos resultados, discutiu-se sobre as contribuições que esta pesquisa trouxe ao autor, sugerindo-se, que outros estudos sejam realizados, visando, assim, a uma formação educativa fundamentada nos princí­pios do letramento.
Sequência didática para leitura de poema como contribuição ao ensino de Lí­ngua Portuguesa
Authors: Lopes-Rossi Maria Aparecida Garcia , Renda Vera Lúcia Batalha de Siqueira
Published: April 2019

A marginalização do poema nas aulas de lí­ngua portuguesa é fato observado por vários pesquisadores, bem como o receio e a insegurança dos professores em trabalhar com esse gênero discursivo. Apesar desse contexto, o gênero tem sido dos mais frequentes em avaliações externas de leitura, como a Prova Brasil. Os livros didáticos não têm contribuí­do para a prática docente, pois, de modo geral, privilegiam os aspectos formais em detrimento da construção dos sentidos do poema, dos contextos sócio-históricos em que se inscrevem esses enunciados e das atitudes responsivas do leitor. Diante da necessidade de contribuir para uma abordagem mais adequada do poema em sala de aula, o objetivo deste artigo é apresentar uma sequência didática de leitura de poema, explicitando seus principais fundamentos teóricos e indicando o modo como contempla questões metodológicas fundamentais na leitura desse gênero e contribui para o desenvolvimento de habilidades de leitura. Fundamenta-se no conceito bakhtiniano de gênero discursivo, nas principais caracterí­sticas do gênero poema e na concepção sociocognitiva de leitura. Como resultado, oferece ao professor subsí­dios para a elaboração de atividades de leitura de poemas que os considere a partir de aspectos de suas dimensões sociocomunicativa, composicional verbal e não verbal, temática e estética. Ademais, contribui para um trabalho teoricamente bem fundamentado, exequí­vel em sala de aula, com os diferentes poemas que o professor selecionar.