bluuebunny/crossref_metadata_2025 huggingface dataset:
A CASE REPORT ON WILSON’S DISEASE: A RARE CLINICAL CONDITION OF COPPER DEPOSITION IN LIVER
Authors: SWATHI G. KISHORE , MANISHA B. , SHARADHA R. , KUMAR DAS SUSHANTA
Published: August 2021

Wilson’s disease is a rare inherited disorder and is characterized by the accumulation of copper in various tissues and also in organs like the liver, brain, kidneys and cornea. Symptoms in paediatrics characteristically appear with hepatic involvement. In this case we have discussed about an eleven-year-old male child, who was presented to the Paediatric department in a tertiary care hospital with chief complaints of yellowish discoloration of eyes, dark coloured urine and high grade fever. Due to the accumulation of copper there were decreased levels of ceruloplasmin and there was an increased 24 hour urinary copper, which confirms the Wilson’s disease in this child. Child was treated with Cephalosporin antibiotics, vitamins, laxative, and bile acid sequestrants. Child showed gradual improvement in clinical symptoms and got discharged without any further event. Quality of evidence was assessed according to the GRADE system. Early diagnosis and management helped to prevent serious complications.
SULFASALAZINE ATTENUATES ULCERATIVE COLITIS IN RATS VIA DOWNREGULATION OF MIRNA-31, METALLOPROTEINASE-3 AND HIGH MOBILITY GROUP BOX1
Authors: BOSHRA SYLVIA A.
Published: August 2021

Objective: This study targets the inhibition of inflammatory mediators and the enhancement of gastrointestinal mucosa healing in ulcerative colitis in rats through sulfasalazine.
Methods: Twenty four female albino rats were divided into 3 groups: normal control, colitis group (rats received 5% dextran sodium sulfate (DSS) in their drinking water for 7 d), sulfasalazine group (500 mg/kg/day was administrated orally one week ahead of DSS and parallel with its administration). The impact of sulfasalazine on intestinal inflammation was investigated via estimation of some inflammatory mediators, namely; serum Leucine rich α 2 Glycoprotein (LRG) as well as colon cAMP, Myloperoxidase (MPO) and TNF-α using ELISA technique as well as gene expression of Trefoil Factor 3 (TFF3), High mobility group box1 (HMGB1), Nuclear factor kappa B (NF-κB) and metalloproteinase-3 (MMP3) and miRNA-31 levels using RT-PCR.
Results: Sulfasalazine substantially decreases the release of LRG, MPO and TNF-α and the expression of HMGB1, NF-κB, MMP3, TFF3 and miRNA31 at p≤ 0.05 compared to colitis group in vivo. Moreover, Sulfasalazine significantly increases the colonic cAMP at p≤ 0.05 in groups of rats treated with DSS.
Conclusion: Sulfasalazine has a protective effect on inflammatory bowel disease causing mucosal healing within the gastrointestinal tract. Additional studies are warranted to explore the molecular mechanism of sulfasalazine in ulcerative colitis and its clinical application.
OPTIMIZATION OF POMEGRANATE PEEL EXTRACTS FOR THE BIOCONVERSION OF THE ELLAGITANNINS TO ELLAGIC ACID USING ASPERGILLUS NIGER, RHIZOPUS ORYZAE AND MIXED CULTURE
Authors: R. SUNDARALINGAM , ANDREW S. NIREN , S. PREMINA
Published: August 2021

Objective: The present study is aimed at optimization of concentration of substrate (pomegranate peel extract) for the production of Ellagic acid using Aspergillus niger and Rhizopus oryzae.
Methods: Test organisms were isolated and identified using standard microbiological techniques. Collected pomegranate peels were dried, grained and used as the substrate for solid-state fermentation. Prepared spore suspension of the test organisms was inoculated and incubated at room temperature. At regular intervals of 24 h, samples were drawn and subjected to analysis of reducing sugar, soluble proteins, hydrolysable tannins and production of extracellular tannase using standard methods.
Results: The results of the present investigation demonstrated the optimum substrate concentration for the active conversion of ellagitannins to ellagic was 15g of A. niger, 20g for R. oryzae and 15g for mixed culture.
Conclusion: From the current work, it was concluded that solid-state bioprocessing of fruit substrates and fruit wastes using fungi has shown to enrich phenolic antioxidants and improve phytochemical consistency.
GENETIC BARCODING AND BOTANICAL STUDIES ON POTHOS SCANDENS L. LEAVES-AN EXTRA-PHARMACOPOEIAL DRUG OF AYURVEDA
Authors: SOJEETRA NIRAL , ACHARYA RABINARAYAN , C. R. HARISHA , SRIVASTAVA SHARAD , MISRA ANKITA , HEGDE SATISHA
Published: August 2021

Objective: This study was undertaken to carry out genetic barcoding, pharmacognostical and phytochemical studies on leaves of Pothos scandens L. belonging to the family Araceae.
Methods: P. scandens, was collected from Cochin, Kerala, during the month of August 2019. Its leaves were examined for pharmacognostical characters and physicochemical, qualitative analysis and HPTLC studies was carried out following standard protocols recommended by the Ayurvedic Pharmacopoeia of India. Genetic barcoding of the fresh tender leaves samples was carried out through following standard methods.
Results: Leaves are simple, alternate, broadly winged petiole. Transverse section through winged petiole portion showed U-shaped, epidermal cell along with cluster crystals. Transverse section through midrib boat-shaped structure, mesophyll undifferentiated, consist parenchyma cell, epidermis with thick cuticle along with waxy coating. Leaves powder shows green in color and microscopy reveals the presence of prismatic crystals, raphides, fibres, acicular crystals and monocot type 1 stomata. The plant is identified as Pothos scandens based on sequence homology and phylogenic analysis. Qualitative results show the presence of carbohydrates, protein, alkaloids and tannins. HPTLC profile shows 7 spots at both short UV and long UV and ferulic acid and kaempferol were identified through quantitative HPTLC.
Conclusion: Pothos scandens is a climber with simple, alternate leaves. Acicular crystals and raphides, mucilaginous cavities, undifferentiated mesophyll are key characters of the identification of its leaf. DNA Barcoding results helps in correct identification of Pothos scandens. The results obtained from the phytochemical study will be helpful in the determination of the strength of purity and also for further standardization of the plant.
DATABASE ENRICHMENTS OF MAO-B THROUGH ENSEMBLE DOCKING
Authors: MATEEV EMILIO , VALKOVA IVA , GEORGIEVA MAYA , ZLATKOV ALEXANDER
Published: August 2021

Objective: The recent growth of highly resoluted crystallographic structures, together with the continuous improvements of the computing power, has established molecular docking as a leading drug design technique. However, the problems concerning the receptor flexibility and the lowered ability of docking software to correctly score the occurred interactions in some receptors are still relevant.
Methods: Recently, several research groups have reported an enhancement in enrichment values when ensemble docking has been applied. Therefore, we utilized the latest technique for a dataset of Monoamine Oxidase–B (MAO-B) inhibitors. The docking program GOLD 5.3 was used in our study. Several docking parameters (grid space, scoring functions and ligand flexibility) were altered in order to achieve the optimal docking protocol.
Results: The results of 200 000+docking simulations are represented in a modest table. The ensembled simulations demonstrated low ability of the docking software to correctly score the actives seeded in the dataset. However, the superimposed complex-1S3B-1OJA-1OJC, achieved a moderate enrichment value equaled to 9. No significant improvements were noted when five complexed receptors were employed.
Conclusion: As a conclusion, it should be noted that in some cases the ensemble docking enhanced the database enrichments, however overall the value is not suitable for future virtual screening. Further investigations in that area should be considered.
Compositional Differences Among Types of Mechanically Separated Chicken and Their Influence on Physicochemical Attributes of Frankfurter-Type Sausages
Authors: Miller Danika K. , Yoder Laura E. , Lonergan Steven M. , Sebranek Joseph G. , Tarté Rodrigo
Published: August 2021

Mechanically separated chicken (MSC) from 2 different separation methods (MSC1, Beehive separator, aged bones [Provisur Technologies, Mokena, IL]; MSC2, Poss separator, fresh bones [Poss Design Limited, Oakville, Ontario, Canada]) and chicken breast trim (CBT) were used as raw materials in frankfurters. Texture, color, and lipid oxidation were measured over a refrigerated storage period of 98 d. Both MSC were higher in fat and lower in moisture than CBT. MSC frankfurters had lower L* and higher a* values than CBT frankfurters, with MSC2 frankfurters having the lowest L* and highest a* (P < 0.05). Thiobarbituric acid-reactive substances values were higher in MSC1 frankfurters (P < 0.05) than in CBT and MSC2 frankfurters. Texture Profile Analysis hardness, cohesiveness, resilience, and chewiness were highest in MSC2 frankfurters. Differences among MSC resulted in detectable differences in finished product attributes, with MSC2 frankfurters being darker and redder and having lower levels of lipid oxidation than MSC1 frankfurters, underscoring the importance of understanding the specific functional attributes of MSC obtained by different processes prior to product formulation and manufacturing.
Eventos adversos en recién nacidos hospitalizados en una Unidad de Cuidados Intermedios
Authors: Chumpitaz-Chávez Y. , Gutiérrez-Crespo H. , Matzumura-Kasano J. , Ruíz-Arias R.A.
Published: August 2021

Introducción: Los recién nacidos (RN) conforman uno de los grupos poblacionales más vulnerables. El riesgo de ocurrencia de un evento adverso durante su hospitalización se incrementa por diversos factores.

Objetivo: Identificar los eventos adversos en recién nacidos hospitalizados en una unidad de cuidados intermedios en 2018.

Metodología: Estudio de tipo descriptivo, diseño transversal y retrospectivo, realizado en la Unidad de Cuidados Intermedios Neonatales del Instituto Nacional Materno Perinatal durante el 2018. Se elaboró una ficha de recolección de datos que constó de nueve ítems correspondientes a procedimientos realizados por el personal de enfermería. Se utilizó un análisis univariado de los datos, presentados en tablas y gráficos.

Resultados: Fueron analizados 73 eventos adversos, la menor edad gestacional fue de 32 semanas, con un máximo de 28 días de hospitalización. 60% de eventos se produjo en los RN más lábiles y con situación de salud compleja, de los cuales, 58% fueron infecciones asociadas a catéter percutáneo o periférico, cuyo germen frecuente fue Sthapylococcus coagulasa negativo. Solo 20.5% de eventos adversos fueron reportados.

Discusión: Los resultados obtenidos coinciden con otras investigaciones en que los factores intrínsecos de los recién nacidos contribuyen en la aparición de eventos adversos; de igual manera, concuerdan en la necesidad de prevenirlos y notificarlos.

Conclusiones: La prematuridad, el tiempo de hospitalización en una unidad crítica y de exposición a diversos procedimientos, incrementaron el riesgo de ocurrencia de eventos adversos en recién nacidos. Detectar oportunamente estos acontecimientos, así como fomentar la cultura de reporte, con el fin de evitarlos.
Biomimetics: An Approach to Enhance Sustainability - An Overview
Authors: M N Ashwath
Published: August 2021

Biomimicry is the study of natural structures, mechanisms and ecosystems to create more ecologically sustainable designs. It plays a vital role in searching for new tools and techniques to solve human problems by adopting natural phenomena. Many experts now view nature through biomimicry for motivation with its instinctive ability for sustainability and proven flexibility to interruption. Biomimetics is not a recent trend; the idea of looking into nature for inspiration is in practice for a long time. Human innovations have borrowed from nature throughout history. Essential elements of biomimicry are ethos, emulate and reconnect. Philosophies of biomimicry emphasise nature’s features, thereby implying that humans have much to learn from nature with evolutionary knowledge. Biomimicry is a modelling tool; the design process is usually divided into two categories; biology to design and challenge to biology. Research folk imitate natural phenomena in three levels viz., form, process, and ecosystem level. Nowadays, biomimicry is used in almost every field, from architecture to computer science. Biomimicry can help with structural quality, water efficiency, zero-waste systems, the thermal atmosphere and energy supply. Fluid-drag-reduction swimsuits inspired by the structure of shark skin, velcro fasteners inspired by burrs, aeroplane shapes inspired by the appearance of birds and stable building systems inspired by termite mounds, honeycombs, and other biomimetic experiments are only a few examples.
Study on Dynamic analysis of Diagrid and Outrigger Structures Subjected to Seismic and Wind Load
Authors: Kumar N Sharath
Published: August 2021

A Comparative study of G+30 story regular, diagrid, outrigger structure is presented. A square shaped floor plan of 18 m × 18m size was considered. ETABS 2016 was used in modeling and analysis of structural members. All structural members were designed as per IS 456:2000, load combinations such as dead load, live load, earthquake and wind loads were considered for analysis and design of the structure. Later Regular, Diagrid and outrigger structural systems were compared; the key results like Base shear, story displacement and story drift are obtained. It is found that diagrid system is efficient in resisting seismic loads and outrigger system is found efficient in resisting wind loads.
Calculating and Understanding the Usefulness of JIRA Developers Communities
Authors: Rai Aayush
Published: August 2021

Tools for project management and bugs or problems following have become useful for managing the event method of the Open supply package. These tools clear the communications task between developers and make certain the quantifiability of the given project. The additional data developers square measure ready to interchange, the brighter square measure the achievements, and therefore the larger is that the limit of developers keen on a change. During this paper, we tend to gift an introductory determined investigation of the companies-structure of developers in JIRA by learning some well-liked comes hosted within the repository. We tend to study however, these firms perform in terms of the given issue’s issue-resolution time. The most contributions of this work square measure the authentication of the survival of firms in developer networks, and therefore, the actual finding that the given issue’s problem resolution time isn't correlative with the importance of a developer company.
Monitoring and Optimization of E-Services in IT Service Desk Systems
Authors: Rai Aayush
Published: August 2021

Information management systems have become the most important system for successfully growing firms. This paper gives techniques and tools for measurement and analysis of e-Services in IT Service Desk Systems. The subject of the research is to propose Business Intelligence tools for their monitoring and optimization. Object of the study are these e-Services. Therefore, the aim of this paper is to look into and analyze the performance of these e-Services in IT Service Desk Systems.
Falsafah Ajaran Kyai Ahmad Dahlan dan Etos Pendidikan Muhammadiyah
Authors: Ruslan Ahmad
Published: August 2021

Melihat sejarah pendidikan Islam di Indonesia terlihat bahwa perkembangannya telah dimulai sejak masuknya Islam ke Indonesia yang diperkirakan pada abad ke 12 Masehi. Muhammadiyah hadir sebagai pelopor, mempunyai andil besar sebagai peletak dasar integrasi antara pendidikan pesantren yang bercorak keagamaan dengan pendidikan umum, yang pada masanya didominasi oleh orang Belanda. Hal tersebut tidak terlepas dari falsafah ajaran Kyai Ahmad Dahlan. Dengan latar belakang tersebut, penelitian ini bertujuan untuk menganalisis falsafah ajaran Kyai Ahmad Dahlan dan etos pendidikan Muhammadiyah untuk pendidikan Indonesia. Penelitian ini menggunakan metode kualitatif dengan teknik pengumpulan datanya menggunakan instrumen kajian dokumen. Hasilnya ditemukan bahwa terdapat praktik-praktik dalam dunia pendidikan Indonesia yang mencerminkan tujuh falsafah ajaran Kyai Dahlan, yaitu: (1) berlandaskan pada tujuan hidup; (2) tidak sombong; (3) tidak taqlid; (4) mengoptimalkan akal; (5) berani untuk kebenaran; (6) berkorban untuk orang banyak; dan (7) adanya kombinasi pengehuan/teori dengan praktik (ilmu amaliyah).  Ketujuh falsafah tersebut, menjadi penting sebagai acuan role model pendidikan di Indonesia yang bukan hanya berorientasi keduniawian, namun juga ada jangka panjang akhirat, dan selalu berpegang teguh pada nilai-nilai kebenaran. Dengan demikian, pendidikan di Indonesia harus diorientasikan pada proses menciptakan manusia yang “Kyai yang berkemajuan” atau orang yang intelek-ulama atau ulama yang intelek.
Pembelajaran Sejarah dan Kebebasan Berpikir
Authors: Santosa Yusuf Budi Prasetya , Hendi Irawan
Published: August 2021

Learning is part of the educational process carried out by teachers and students. One of the lessons carried out is history learning. A part of the history learning process is still dominated by history teachers. Students feel they are not actively involved in the history learning process. History teachers still respect historical knowledge without providing sufficient opportunities for students. History learning should provide opportunities to think logically for students. Freedom of thought in learning history will have a positive impact on learning history itself and students. The purpose of this study is intended to provide a perspective on the importance of providing freedom of thought in history learning for students. The method used in this research is literature study, both technical and non-technical literature. The result was found that freedom of thought in history learning can make the learning process dynamic. Freedom of thought can develop students' logical and systematic reasoning abilities. Differences in interpretation due to diversity of thinking make the learning process run dialectically.

 

Abstrak

Pembelajaran adalah bagian dari proses pendidikan yang dilakukan oleh guru dengan peserta didik. Salah satu pembelajaran yang dilakukan ialah pembelajaran sejarah. Sebagian dari proses pembelajaran sejarah masih didominasi oleh guru sejarah. Peserta didik merasa tidak dilibatkan secara aktif dalam proses pembelajaran sejarah. Guru sejarah masih menghegomoni pengetahuan kesejarahan tanpa memberikan kesempatan yang cukup bagi peserta didik. Pembelajaran sejarah seharusnya memberikan kesempatan berpikir secara nalar bagi peserta didik. Kebebasan berpikir dalam pembelajaran sejarah akan berdampak positif bagi pembelajaran sejarah itu sendiri dan peserta didik. Tujuan penelitian ini dimaksudkan untuk memberikan sebuah sudut pandang akan pentingnya memberikan kebebasan berpikir dalam pembelajaran sejarah bagi peserta didik. Metode yang digunakan di dalam penelitian ini ialah studi literatur, baik literatur teknis maupun non-teknis. Hasilnya ditemukan bahwa kebebasan berpikir dalam pembelajaran sejarah dapat membuat proses pembelajaran menjadi dinamis. Kebebasan berpikir dapat mengembangkan kemampuan penalaran peserta didik secara logis dan sistematis. Perbedaan interpretasi akibat keberagaman berpikir menjadikan proses pembelajaran berjalan secara dialektis.
Pendidikan Bercorak Sufisme dalam Pemikiran Abdul Munir Mulkhan
Authors: Ahmad Mubarak
Published: August 2021

This study aims to explain and analyze Abdul Munir Mulkhan's sufism-style education thoughts in dealing with the problems of modern society. This thought is an exploration of ideas that aims to find a contemporary educational format that can overcome the pathologies of modernity and modernism. This study uses a historical method, with primary data derived from interviews with sources and secondary data from literature reviews of the works of other sources and writers with related themes. This research finds that the concept of education with Abdul Munir Mulkhan’s sufism-style is an attempt to deconstruct theological doctrines in Islam and conventional sufism and direct them to the functionalization of Islam in social life. The epistemology of Sufism developed in Abdul Munir Mulkhan's sufism-style education aims to synthesize an objective-empirical paradigm with a subjective-intuitive nature so as to create an integrative paradigm model. Abdul Munir Mulkhan's sufism-style education ultimately aims to open people's internal awareness of situations, conditions, and spiritual responsibilities that can lead people to improve their self-quality and be responsive to the changes that occur around them, as well as to improve the welfare of other humans through the science of charity and the scientific charity.

 

Abstrak

Penelitian ini bertujuan untuk menjelaskan dan menganalisis pemikiran pendidikan bercorak sufisme Abdul Munir Mulkhan dalam menghadapi problematika masyarakat modern. Pemikiran tersebut merupakan eksplorasi pemikiran yang bertujuan mencari format pendidikan kontemporer yang dapat mengatasi patologi modernitas dan modernisme. Penelitian ini menggunakan metode historis, dengan data primer berasal dari hasil wawancara dengan narasumber serta data sekunder berasal dari telaah pustaka terhadap karya-karya narasumber dan penulis lainnya dengan tema yang terkait. Penelitian ini menemukan bahwa konsep pendidikan bercorak sufisme Abdul Munir Mulkhan merupakan upaya mendekonstruksi doktrin-doktrin teologis dalam Islam dan tasawuf konvensional dan mengarahkannya pada fungsionalisasi agama Islam dalam kehidupan sosial. Epistemologi tasawuf yang dikembangkan dalam pendidikan bercorak sufisme Abdul Munir Mulkhan bertujuan untuk menyintesis paradigma objektif-empiris dengan subjektif-intuitif sehingga tercipta suatu model paradigma yang bersifat integratif. Pendidikan bercorak sufisme Abdul Munir Mulkhan pada akhirnya bertujuan untuk membuka kesadaran internal manusia terhadap situasi, kondisi, dan tanggungjawab spiritual yang dapat mengantarkan manusia ke arah perbaikan kualitas diri dan tanggap terhadap perubahan yang terjadi di sekitarnya, sekaligus dapat menyejahterakan manusia lainnya melalui ilmu amaliah dan amal yang ilmiah.
Kontribusi Ki Bagus Hadikusumo dalam Sidang BPUPKI Mei-Juli 1945
Authors: Santosa Yusuf Budi Prasetya , Rina Kurnia
Published: August 2021

Abstract

In the field of political struggle, the leaders of the national movement were jointly preparing for an independent Indonesia. One of the efforts to prepare for Indonesian independence was through the BPUPKI session which took place from May to July 1945. BPUPKI was the preparation committee for Indonesian independence in the form of Japan which was originally used as a propaganda tool but instead used as a means of struggle for national movement figures. National movement figures who sit in BPUPKI come from various religious and ideological backgrounds. One of the national movement figures who became a member of BPUPKI was Ki Bagus Hadikusumo. Ki Bagus Hadikusumo is the leader of the Islamic organization, Muhammadiyah, which contributed to fighting for and fighting for Indonesian independence through BPUPKI. This study intends to find out about how Ki Bagus Hadikusumo's contribution to the trial of BPUPKI in May-July 1945. The method used in writing this article is a literature study. The results of the study revealed that Ki Bagus Hadikusumo made a big contribution to the BPUPKI session. There are two things put forward by Ki Bagus Hadikusumo, first is the concept of an independent Indonesia, which is a state that is run on the sovereignty of the people, and secondly, fighting for Islam as the legal foundation for an independent Indonesian state.

Keywords : BPUPKI, Ki Bagus Hadikusumo, Islam

Abstrak

Di medan perjuangan politik para tokoh pergerakan nasional bersama-sama mempersiapkan Indonesia merdeka. Salah satu upaya dalam rangka mempersiapkan kemerdekaan Indonesia ialah melalui sidang BPUPKI yang berlangsung dari Mei hingga Juli 1945. BPUPKI merupakan panitia persiapan kemerdekaan Indonesia bentukkan Jepang yang semula digunakan menjadi alat propaganda, namun justru dijadikan sebagai alat perjuangan bagi para tokoh pergerakan nasional. Para tokoh pergerakan nasional yang duduk di dalam BPUPKI berasal dari berbagai latar belakang agama dan ideologi. Salah satu diantara tokoh pergerakan nasional yang menjadi anggota dari BPUPKI adalah Ki Bagus Hadikusumo. Ki Bagus Hadikusumo adalah pemimpin organisasi Islam, Muhammadiyah yang turut berkontribusi dalam memperjuangkan dan memperisapkan kemerdekaan Indonesia melalui BPUPKI. Penelitian ini bermaksud mencari tahu mengenai bagaimana kontribusi Ki Bagus Hadikusumo dalam persidangan BPUPKI Mei-Juli 1945. Metode yang digunakan dalam penulisan artikel ini yaitu studi pustaka. Hasil kajian mengemukakan, bahwa Ki Bagus Hadikusumo memberikan kontribusi yang besar dalam sidang BPUPKI. Terdapat dua hal yang dikemukakan oleh Ki Bagus Hadikusumo, pertama ialah konsep negara Indonesia merdeka adalah negara yang dijalankan atas kedaulatan rakyat, dan kedua memperjuangkan Islam sebagai pondasi hukum bagi negara Indonesia merdeka.

Kata kunci : BPUPKI, Ki Bagus Hadikusumo, Islam
Tubagus Muslihat: Kiprah Pejuang Kemerdekaan di Bogor 1942-1945
Authors: Saputra Anggas Iga , Kurniawati Kurniawati , Martini Sri
Published: August 2021

Kiprah Tubagus Muslihat dalam ranah merebut maupun mempertahankan kemerdekaan begitu besar, namun peran tersebut lebih banyak dikenal dalam kancah lokal sedangkan untuk tarah nasional begitu minim. Maka dari itu penelitian ini bertujuan untuk mendeskripsikan situasi Bogor pada zaman Jepang dan pada masa Revolusi Kemerdekaan, serta kiprah Tubagus Muslihat sebagai pejuang kemerdekaan di Bogor pada tahun 1942-1945. Metode dalam penelitian ini yaitu metode historis. Hasil dari penelitian ini berupa peran Tubagus Muslihat dalam perebutan gedung Bogor Shucokan, perannya dalam pertempuran di Lewiliang Bogor, dan saat pertempuran di stasiun Bogor.
Pengelolaan Pasar Jongkok di Tembilahan Tahun 2009-2015
Authors: Okta Ayumi Tari , Ahmal Ahmal , Asril Asril
Published: August 2021

Penelitian ini bertujuan untuk mengetahui Pengelolaan Pasar Jongkok di Tembilahan 2009-2015 (management of the pasar Jongkok in Tembilahan ).  Keberadaan Pasar Jongkok menjadi salah satu elemen penting dalam kehidupan masyarakat Tembilahan dan menjadi salah satu  penggerak roda perekonomian masyarakat dan sosial. Pasar Jongkok awalnya didirikan pada tahun 1936 namun mengalami kemunduran hingga keberadaan Pasar Jongkok ini mulai muncul kembali pada tahun 1980-an. Pasar Jongkok ini memberikan dampak sosial bagi masyarakat Tembilahan serta mampu meningkatkan interaksi antara pedagang yang berjualan di pasar jongkok tersebut.  Penelitian ini menggunakan penelitian kualitatif dengan pendekatan sejarah. Maka dari itu peneliti menggunakan empat tahapan yang terdiri dari: heuristik, kritik sumber, interpretasi dan historiografi. Pada tahapan heuristik peneliti menggunakan pedagang serta dinas pengelola yang ada sebagai narasumber dan menjadikannya sumber primer. Untuk sumber sekunder, peneliti lebih memanfaatkan buku sebagai sumber utamanya dan didukung dengan artikel jurnal. Selanjutnya peneliti juga menerapkan kritik sumber serta interpretasi demi mendapatkan hasil yang valid dari berbagai data yang didapatkan. Kemudian baru dilakukan historiografi. Hasil yang ditemukan dalam penelitian ini berupa sejarah pasar Jongkok di kota Tembilahan, pengelolaan pasar Jongkok di kota Tembilahan serta  dampak keberadaan pasar Jongkok di kota Tembilahan.
Family reproductive attitudes: comprehensive analysis in the regional context
Authors:   the Pedagogical institute of the Pacific State University, Trusova Е. A.
Published: August 2021

Тhe article is devoted to a comprehensive study of the families’ reproductive attitudes, as a basis for understanding the complex demographic situation in the country and the Khabarovsk territory, due to a decrease in the birth rate and increase in the natural population decline. Empirical basis of the research was the results of all-Russian and regional sociological studies, as well as psych diagnostic methods of sociological surveys and diagnostics of families in the Khabarovsk territory. On their basis, the author analyzed the following components of reproductive attitude: awareness (cognitive component), attitude towards children (emotional component) and readiness for childbirth (behavioral component).The content of reproductive attitude of the respondent families main components was revealed, their hierarchy was determined, the values of the spouses and their gender characteristics were compared. It was concluded that the family's decision to have children is influenced by a complex of objective (socio-economic) and subjective (psychological) factors, among which the main role is played by the attitude of the spouse and, as a consequence, her position in determining the number of children in the family.
Аssessment of the relationship between education and income in the region
Authors:   the Economic Research Institute of FEB RAS, Dzhabbarova E. Kh.
Published: August 2021

Human capital is an integral assessment of the quantitative and qualitative characteristics of the population. Human capital depends on the economic and social processes in the regions. The results of economic research show that the human consists of two parts: amount population and the qualitative characteristics of the population. The article discusses the problems associated with the formation of a systematic approach to the formation of high-level human capital. The author analyzes the main research results of the relationship between the characteristics of human capital in Russia as a whole and, in particular, in the Far-Eastern region. The main method for analyzing the data obtained is correlation and regression analysis. The author comes to the conclusion that there is a «helix» of interaction between the level of income of the population and the level of education in the process of forming human capital.
Self-employed in the Far East of Russia
Authors:   the Pacific National University, Solovyeva Ju. N.
Published: August 2021

The article presents an analysis of the dynamics of self-employed citizens of the Far-Eastern federal district. The quantitative effect as a result of introduction of a special tax regime «Tax on professional income» is presented. An assessment of expectations of the local authorities in the regions of the Far East from the introduction of special tax regime is given. A retrospective of status of the self-employed at the legislative level is presented. An assessment of the most rapidly developing spheres of activity of the self-employed is given, an attempt is made to draw up a social portrait of this category of citizens. The analysis of job search activity of the self-employed and their hiring by employers has been carried out. It is shown that as a result of lack of exhaustive concept of the category of «self-employed», enshrined at the legislative level, there is confusion with the self-identification of persons who consider themselves as self-employed citizens. In addition, there are a number of economic, legal and social problems that the self-employed face today. According to the author, development of the legislative activity in this direction (development of the state support programs, national projects in the field of small and medium-sized businesses, expansion of the rights of the self-employed, etc.), expansion of the economic and sociological research of this category of citizens (in particular, selective observation, compilation an exhaustive social portrait, inclusion of a large social group of self-employed in the social structure of the society) contributes to a more active «exit from the shadows», legalization of implementation of their own activities, overcoming difficulties arising on the way of self-employed, growth of trust in the authorities. The conclusions are formulated on the basis of results of a sociological survey of citizens.
Creative aspect of regional development in the Message of the President of the Russian Federation
Authors:   The Far-Eastern Institute of Management – branch of RANEPA, Medvedeva N. V.
Published: August 2021

The article contains an expert opinion on regional development issues reflected in the Message of the President of the Russian Federation of 2021 (hereinafter – the Message). It is noted that the issues of regional development in the Message correspond to the logic of the principles of coordinated functioning and interaction of the bodies included in the public power system. It has been shown that along with social measures, the key idea of the Message is the economic development of the regions. The prerequisites and setting of regional development goals within the framework of the new regional support scheme proposed in the Messageare revealed. The regional block of instructions for implementation of the Message is presented, the implementation of which will ensure the fulfillment of the role of the Message as a document of spatial development and equality of opportunities for the different territories and population groups.
Batch effects in population genomic studies with low-coverage whole genome sequencing data: causes, detection, and mitigation
Authors: Lou Runyang Nicolas , Therkildsen Nina Overgaard
Published: August 2021

Over the past few decades, the rapid democratization of high-throughput
sequencing and the growing emphasis on open science practices have
resulted in an explosion in the amount of publicly available sequencing
data. This opens new opportunities for combining datasets to achieve
unprecedented sample sizes, spatial coverage, or temporal replication in
population genomic studies. However, a common concern is that
non-biological differences between datasets may generate batch effects
that can confound real biological patterns. Despite general awareness
about the risk of batch effects, few studies have examined empirically
how they manifest in real datasets, and it remains unclear what factors
cause batch effects and how to best detect and mitigate their impact
bioinformatically. In this paper, we compare two batches of low-coverage
whole genome sequencing (lcWGS) data generated from the same populations
of Atlantic cod (Gadus morhua). First, we show that with a
“batch-effect-naive” bioinformatic pipeline, batch effects severely
biased our genetic diversity estimates, population structure inference,
and selection scan. We then demonstrate that these batch effects
resulted from multiple technical differences between our datasets,
including the sequencing instrument model/chemistry, read type, read
length, DNA degradation level, and sequencing depth, but their impact
can be detected and substantially mitigated with simple bioinformatic
approaches. We conclude that combining datasets remains a powerful
approach as long as batch effects are explicitly accounted for. We focus
on lcWGS data in this paper, which may be particularly vulnerable to
certain causes of batch effects, but many of our conclusions also apply
to other sequencing strategies.
Patients with Diabetes Detected Incidentally in the Emergency Department
Authors: Sahin Levent , Ercin Dogan
Published: August 2021

Background: This study was conducted to determine the frequency and
clinical features of patients who were diagnosed incidentally as having
diabetes mellitus (DM) in the emergency department. Aim: Our aim was to
investigate the frequency of DM in patients whose high blood glucose
levels were detected, and to examine the subsequent treatment these
patients. Methods: The participants were selected from among patients
who had a glucose level of ≥200 mg/dL and admitted to emergency
department with symptoms of hyperglycemia in the past 1 year. Age, sex,
presence of chronic disease, and the laboratory blood parameter results
of the patients were recorded. We divided the patients into three groups
as those who had never been admitted to clinics for treatment, those who
were admitted and given treatment, and not given treatment. Results:
According to their sexes, 73 (52.1%) were male and 67 (47.9%) were
female. It was determined that 86 of the 140 patients included in the
study were admitted to clinics for treatment. It was determined that no
medication was given to 50 of these patients, but treatment was
initiated in 36. Patients with glucose level ≥300 mg/dL were found to be
receiving more treatment significantly (p=0.031). Conclusions: In this
study, diabetic patients whose blood sugar is between 200-300 mg/dL
should be sent to the DM related clinic immediately when diagnosed in
the emergency department.
Sarcoidosis and renal cell carcinoma: a very rare association
Authors: Khadhar Mariem , jebali hela , mami ikram , hamida fethi ben , rais lamia , benfatma lilia , zouaghi karim , zhini alia , haouet slim
Published: August 2021

Granulomatosis reaction associated with tumor has been designated as
sarcoid-like reaction. Very few cases of association of systemic
sarcoidosis and neoplasia have been reported. We reported two cases of
sarcoidosis and renal cell carcinoma.
Editorial
Authors: Roa Vega María Ligia
Published: August 2021

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Digestibilidad in vivo de morera (Morus alba), con diferentes niveles de concentrado en curies (Cavia porcellus)
Authors: Villegas González Daniel Enrique , Roa Vega Maria Ligia
Published: August 2021

La carne de cuy (Cavia porcellus) tiene una elevada demanda en Ecuador, Perú y Colombia principalmente en Pasto. Se ha evidenciado que su consumo se ha extendido hacia gran parte del país, existen pocos estudios que involucren estos animales y mucho menos evalúen las estrategias alimenticias en su comportamiento en cuanto a metabolismo y aprovechamiento de nutrientes. De la misma manera no se conocen alternativas teniendo en cuenta que esta especie consume gran cantidad de forrajes, lo que favorece por la disminución en costos de producción de carne, evitando el uso de concentrado al 100%, puesto que este insumo tiene un costo elevado, además, influye de manera negativa en sabor de la carne. El presente estudio se realizó en el municipio de Villavicencio, con una altitud de 465 metros sobre el nivel del mar, temperatura promedio de 27°C y precipitación anual entre 1900 y 3250 milímetros. Los cuyes se fueron distribuidos en cuatro tratamientos con tres repeticiones y cada una con dos unidades experimentales, para un total de 24 animales con un peso promedio 1027.5 ± 19 g distribuidos en un diseño completamente al azar, los cuales se alojaron en jaulas y sometidos a un periodo de acostumbramiento de cinco días, y cuatro de toma de datos que se realizó a partir del día quinto. Para cada repetición se tomaron cuatro muestras, las cuales fueron evaluadas en el Laboratorio de Nutrición Animal de la Universidad de los Llanos. Las dietas suministradas por día a todos los tratamientos fueron morera fresca (MF) ad libitum, suplementados de la siguiente manera: T1 con concentrado comercial (CC), 1% de su peso vivo (PV); T2: CC, 2% de su PV; T3: CC 3% de su PV y T4: únicamente MF. Se realizaron análisis nutricionales a las dietas y excretas. Las variables a evaluar fueron coeficientes de digestibilidad (Cod) de la materia seca (MS), proteína, grasa, extracto no nitrogenado (ENN), fibra cruda (FC), % nutrientes digestibles totales (NDT); cálculos de: Energía digestible (ED) y energía metabolizarle (EM), Cod: método que valora el consumo y la excreción de los nutrientes para determinar el aprovechamiento en el tracto digestivo. El estudio fue importante en el sentido de que se estimaron valores de referencia para el sector en términos de digestibilidad de la morera y el concentrado comercial en cuyes. Se determinó que las dietas de mejor comportamiento (P<0.05), fueron CC al 2% (T2) y 3% (T3) del PV, a pesar que la que mayores valores de digestibilidad obtenidos fue para T3, el T2 observó un comportamiento similar según el estudio, pudiéndose utilizar sin disminuir drásticamente la digestibilidad y ahorrando un 1% de concentrado por animal representado un ahorro importante.
Alimentación de ovinos en regiones del trópico en Colombia
Authors: Avendaño Rodríguez Víctor Alexis , Navarro Ortiz Cesar Augusto
Published: August 2021

En este trabajo se hace una exploración minuciosa para mostrar al sistema de producción ovina como una alternativa productiva y promisoria para un futuro próximo de las regiones tropicales Colombianas, correlacionado con la relevancia presentada a nivel nacional en los últimos tiempos y opción socio económica viable para los pequeños productores de los centros poblados afectados por el posconflicto; resaltando la falta de tecnificación para este eslabón pecuario por la baja productividad por el manejo alimenticio, el desconocimiento de la especie y la cultura bovina de tradición. Con la revisión del material bibliográfico y la contextualización de la región intertropical, se determinan las necesidades de enfatizar, en orden de importancia, la producción eficiente de forrajes de alto valor nutricional y biológico, un esquema de selección genética detallado analizando la raza y sus bondades, y la visión empresarial competitiva para producción de carne. Además de los factores más relevantes para evaluar la eficiencia de la dieta, por medio de la condición corporal y el estatus sanitario de los individuos. Lo anterior favoreció para concluir, la necesidad de establecer en la zona un paquete tecnológico integral, sirviendo de base para la organización de las producciones actuales y el establecimiento adecuado de futuras granjas ovinas, desde el aspecto nutricional hasta el factor comercial.
Memorias del segundo encuentro de emprendedores agropecuarios en la Amazorinoquia “sostenibilidad, innovación y seguridad alimentaria”
Authors: Ramírez Villa Luis Carlos , Díaz Arias Camilo Andrés
Published: August 2021

La Universidad de los Llanos, la Facultad de Ciencias Agropecuarias y Recursos Naturales, en acompañamiento de REUNE nodo Amazorinoquía invitaron a la comunidad académica: Docentes, Egresados, otros profesionales y empresarios a participar en ll Encuentro de Emprendedores Agropecuarios en la Amazorinoquia “Sostenibilidad, innovación y seguridad alimentaria”, mediante la presentación de sus experiencias de investigación o emprendimiento relacionadas con la sostenibilidad agropecuaria, innovación agropecuaria, seguridad alimentaria y también aquellas relacionadas con el manejo en el sector de los efectos de la pandemia Covid-19. Las experiencias fueron presentadas en resúmenes para su publicación. Los temas tratados fueron: conservación de flora y fauna, producción y transformación de productos a través de energías renovables, manual de procesos para producir alimentos inocuos y aptos para consumo, investigación de asociatividad en pequeños productores de leche, transformación primaria del caucho natural. El evento fue organizado por Facultad de Ciencias Agropecuarias y Recursos Naturales, Oficina de Proyección social, Coordinado por el semillero de investigación ECODER y el grupo de Investigación Agroforesteria, con la colaboración REUNE nodo Amazorinoquia.
Peripherally Inserted Central Catheters in Children: A Prospective Single-Center Analysis of Associated Complications
Authors: Canci Tavares Filomena , AlBandari Maria , Donnellan John
Published: August 2021

Highlights

Objective: To assess performance of peripherally inserted central catheters (PICCs) in pediatric patients Design: Prospective observational study

Setting: Academic pediatric tertiary referral center

Study Population: Children aged less than 18 years with PICCs inserted in Interventional Radiology from January 2019 to June 2019

Outcome Measures: Number of catheters remaining in situ until completion of intended therapy; and for those removed prematurely, the type and rate of complications

Results: A total of 88 PICCs (40 uncuffed, 48 cuffed) were inserted in 77 children. Overall, 72% (n = 63) of all catheters remained in situ until intended therapy was completed. Complications resulting in premature removal occurred in 24% of catheters (rate of 3.89/1000 catheter-days). Complications included catheter malfunction (2.04 per 1000 catheter-days), infection (1.67 per 1000 catheter-days), and thrombosis (0.18 per 1000 catheter-days). Complications were further recorded by catheter type. In patients with uncuffed catheters, the overall complication rate was observed to be 6.74 per 1000 catheter-days. In patients with cuffed catheters, the overall complication rate was observed to be 1.10 per 1000 catheter-days.

Conclusions: Findings suggest that cuffed PICCs may provide additional benefits toward optimizing catheter performance and securement in neonatal and pediatric patients. This can contribute to improved likelihood of complication-free PICC therapy and successful therapy completion. Pediatric patients present unique challenges and considerations for clinicians planning PICC therapy. Additional studies are needed to identify effective strategies to mitigate catheter failure in neonatal and pediatric populations.
Prescribing Trends of Antidiabetes Medications in Patients With Type 2 Diabetes and Diabetic Kidney Disease: A Cohort Study
Authors: Harris Samantha T. , Patorno Elisabetta , Zhuo Min , Kim Seoyoung C. , Paik Julie M.
Published: August 2021

OBJECTIVE

To assess changes in antidiabetes medication class prescriptions over time among patients with diabetic kidney disease (DKD), characteristics of patients prescribed these medications, and prescribers’ specialty.

RESEARCH DESIGN AND METHODS

We conducted a cohort study design using insurance claims data between 2013 and the first quarter of 2020 (2020Q1). Included are adult patients with DKD who initiated a new antidiabetes medication between 2013 and 2020Q1 (N = 160,489 patients). The primary outcome is the yearly and quarterly percent of medication initiation for each antidiabetes medication class over all antidiabetes medication initiations.

RESULTS

For patients with DKD, sodium–glucose cotransporter 2 inhibitor (SGLT2i) and glucagon-like peptide 1 receptor agonist (GLP-1RA) initiations steadily increased between 2013 and 2020Q1. Internists and endocrinologists were the most frequent prescriber specialties. Patients <65 years of age had a larger percentage of all initiations that were SGLT2i or GLP-1RA, 16% and 23%, respectively, in 2019, and patients >75 years of age had a smaller percentage of all initiations that were SGLT2i or GLP-1RA, 11% and 13%, in 2019.

CONCLUSIONS

For patients with DKD, SGLT2i and GLP-1RA prescriptions have increased over time, likely reflecting evolving prescribing patterns in response to the results of recent clinical trials and new clinical guidelines.