bluuebunny/crossref_metadata_2025 huggingface dataset:
BNST GluN2D-Containing NMDA Receptors Influence Anxiety- and Depressive-like Behaviors and ModulateCell-Specific Excitatory/Inhibitory Synaptic Balance
Authors: Salimando Gregory J. , Hyun Minsuk , Boyt Kristen M. , Winder Danny G.
Published: April 2020

Excitatory signaling mediated by NMDARs has been shown to regulate mood disorders. However, current treatments targeting NMDAR subtypes have shown limited success in treating patients, highlighting a need for alternative therapeutic targets. Here, we identify a role for GluN2D-containing NMDARs in modulating emotional behaviors and neural activity in the bed nucleus of the stria terminalis (BNST). Using a GluN2D KO mouse line (GluN2D−/−), we assessed behavioral phenotypes across tasks modeling emotional behavior. We then used a combination ofex vivoelectrophysiology andin vivofiber photometry to assess changes in BNST plasticity, cell-specific physiology, and cellular activity profiles. GluN2D−/−male mice exhibit evidence of exacerbated negative emotional behavior, and a deficit in BNST synaptic potentiation. We also found that GluN2D is functionally expressed on corticotropin-releasing factor (CRF)-positive BNST cells implicated in driving negative emotional states, and recordings in mice of both sexes revealed increased excitatory and reduced inhibitory drive onto GluN2D−/−BNST-CRF cellsex vivoand increased activityin vivo. Using a GluN2D conditional KO line (GluN2Dflx/flx) to selectively delete the subunit from the BNST, we find that BNST-GluN2Dflx/flxmale mice exhibit increased depressive-like behaviors, as well as altered NMDAR function and increased excitatory drive onto BNST-CRF neurons. Together, this study supports a role for GluN2D-NMDARs in regulating emotional behavior through their influence on excitatory signaling in a region-specific manner, and suggests that these NMDARs may serve as a novel target for selectively modulating glutamate signaling in stress-responsive structures and cell populations.

SIGNIFICANCE STATEMENTExcitatory signaling mediated through NMDARs plays an important role in shaping emotional behavior; however, the receptor subtypes/brain regions through which this occurs are poorly understood. Here, we demonstrate that loss of GluN2D-containing NMDARs produces an increase in anxiety- and depressive-like behaviors in mice, deficits in BNST synaptic potentiation, and increased activity in BNST-CRF neurons known to drive negative emotional behavior. Further, we determine that deleting GluN2D in the BNST leads to increased depressive-like behaviors and increased excitatory drive onto BNST-CRF cells. Collectively, these results demonstrate a role for GluN2D-NMDARs in regulating the activity of stress-responsive structures and neuronal populations in the adult brain, suggesting them as a potential target for treating negative emotional states in mood-related disorders.
Law Enforcement of Motorized Vehicles with Muffler Racing by Magelang City Police
Authors: Kurniadi Damas Reza
Published: April 2020

Muffler is a facility to dispose of exhaust gases that result from combustion in a motorcycle engine when the engine is started. Motorcycle riders often replace the standard muffler with a harder or racing muffler. Basically, muffler modification is considered a violation of the law. Based on the description above, the formulation of the problem that will be discussed in this research is how to implement regulations regarding the use of motor racing exhausts on public roads ?, And how the actions taken by the Magelang city police resort in dealing with the use of mufflers racing? The results of research and discussion indicate that law enforcement in the case of the use of motorcycle racing mufflers is included in law enforcement in the field of traffic. Law enforcement in the field of traffic can be grouped into preventive and repressive law enforcement. The conclusion drawn from this study is that the implementation of regulations regarding the use of motorbikes with racing mufflers on public roads has been carried out in accordance with the law. The action taken by Police is to carry out traffic and seizure actions taking into account the effects of pollution on the use of mufflers racing which not only damage human health but also damage the environment
Pre-Release Treatment in Class II A Correctional Institution of Pekalongan
Authors: Muslim Ichwanul Fauzi
Published: April 2020

Implementing pre-release treatment for a convict is one of the tasks of a correctional institution as a Technical Implementation Unit in the field of contruction. Thus, a correctional institution, in implementing correctional guidance, must consider human right protections aspects for them to be balanced with the public interest. Convict constructions in a correctional institution is an effort conducted to enforce the law. This study, entitled “The Juridical Observation of Pre-Release Treatment in Class II A Correctional Institution of Pekalongan”, has two research questions, including how the pre-release treatment is a determined in Indonesia positif law and what obstacles are faced in the pre-release treatment process in Class II A Correctional Institution of Pekalongan. The study aims at finding out the provisions of the pre-release treatment in Indonesian positive law, The provision of pre-release treatment is one form of society contruction processes that is conducted based on correctional system which aims to prepare the convicts to be able to integrate with the society. Therefore, they are able to play a role as a society member who owns freedom and responsibility before they are actually released.
Surrogate Mother Agreement and the Effect on Children's Status Born
Authors: Al Yadainy Filda Achmad
Published: April 2020

That surrogate mother is one of the IVF techniques (fertilization in vitro), the seeds must come from the husband and wife pair and then put in the womb of another woman. After the child is born another woman is obliged to give the child to a married couple who ordered the agreed agreement. In this research, the author aims to find out how the validity of the agreement surrogate mother and what is the legal status of children born from agreements surrogate mother. Agreement is asomething that someone or some people commit themselves to someone or some people who tie themselves to others, and while Legitimate children are children born in or due to a legal marriage. The theory used (statue approach) by examining all regulatory laws. Results of research on the validity of the agreement surrogate mother, the agreement is invalid because it is based on the fourth condition in terms of the validity of an agreement Pasal 1320 KUHPerdata that is, due to "the existence of halal reasons" and as for the status of the child from the status of the child who was born that the child is the child of a surrogate who already conceived and gave birth to her.
Children as Victims of Sexual Violence Committed by Parents: A Criminological Perspective
Authors: Susanto Joko , Utari Indah Sri
Published: April 2020

As the technology progress and human civilization, crime which is happened not only involve a crime towards life and property, but also a crime towards morality that is increasing. As a social problem criminal act of sexual violence in nowadays has been done by adult or elderly, even from a father to his children, and most of the victim are women and children. Sexual violence is a violence which is happened because of sexuality issues. The subject of this journal is to know how the protection law for the young victim of sexual violence which is done by their parents. Discussion method which is used is Act Approach (The Statute Approach). Sexual violence usually is done toward their partner. This violence includes all of sexual violence types which are done by anyone to his sexual partner. Including sexual violence which is done by a husband to his wife, just because he wants to satisfy his biological lust. Criminal act of rape is worried, moreover when  the victim are children which are still underage, because it will affect the developing of children’s  psychology, inflict lifelong trauma, and the more pitiful is the children of sexual violence victim can be a prostitution worker. So that it ruins their future.
Digital Evidence Acquisition System on IAAS Cloud Computing Model using Live Forensic Method
Authors: Sudyana Didik , Lizarti Nora
Published: April 2020

Cloud Computing is a technological development that has been warmly discussed in recent years and has seen significant increases in usage, especially on the IAAS Cloud Computing model. The high rate of development of IAAS Cloud Computing model is in line with the high number of crimes involving IAAS Cloud Computing model on server virtualization. When a computer crime occurs and a digital forensic investigation will be carried out to uncover the case, it raises issues related to the acquisition of digital evidence. Because the acquisition model in general, it is done only to one operating system, while in virtualization there is more than one operating system, so the acquisition technique in general cannot be used because it takes only one operating system involved crime, and cannot acquire the whole data server related privacy data in other virtual operating systems. Therefore, research to make the acquisition system of server virtualization is needed. The focus in this research is to make system acquisition in server virtualization Proxmox using the live forensic method to produce a system that can acquire virtualization without disrupting the overall data server and in accordance with the principle of digital forensics. The resulting acquisition system can be a reference for investigators to investigate the IAAS Cloud Computing model on Proxmox virtualization and facilitate the investigator's work in the use of the system because the investigator simply chooses which virtual operating system to acquire, after which the system will work on its own the acquisition.
“A Dança da Mente”: workshop psicodramático
Authors: Carriço Paula
Published: April 2020

Este trabalho tem como objetivo um encontro entre a escrita de Al Berto (“mente que escreve sobre o corpo”) e a dança-teatro de Pina Bausch (“corpo que dança sobre a mente”) através de uma vivência psicodramática. A partir destes dois eixos, pretende-se mapear o corpo como instrumento utilizado nestas formas de arte e experiência subjetiva. Enquanto componente estrutural da identidade e mediadora da relação, utilizamos as imagens do corpo como se fossem construção de novos percursos. A nosso ver estes tipos de técnicas podem ser utilizados em várias vertentes clínicas.
"Contando os Plaquê de 100": o Significado da Ostentação Para Além do Funk
Authors: Moreira da Silva Luis Fernando , Santos Natacha Secco , Cassandre Marcio Pascoal
Published: April 2020

A palavra ostentação tem sido usada em diversos meios de comunicação. Esse termo ganhou força com o surgimento do funk ostentação, portador de letras que remetem ao consumo. Esse termo e suas variáveis, como: ostensível, ostentar e ostensivo têm no senso diversos significados, como sucesso, posse de bens materiais, evidenciar o que se tem. Este artigo, a partir de análises bibliográficas e bibliométricas, tem o objetivo de lançar luz ao tema, buscando sua construção ao longo do tempo em diversas áreas do conhecimento, afim de produzir um entendimento mais amplo do que essa palavra representa. Para tanto, os resultados das pesquisas sugerem que existem aspectos profundos no ato de comprar, sendo o desejo, as modos, e a vontade de possuir bens e objetos que causem boa impressão ou statussão alguns desses fatores. A ostentação está aglutinada ao querer, e com ela a necessidade de mostrar, portanto, não basta possuir, é preciso que a posse seja ostensível.
Formação de Estratégias em Programa de Pós-Graduação em Administração
Authors: Silva Lorenna Karolly Santos da , Neves Regina Coeli Lafayette , Wanderley Lilian Soares Outtes , Lima Manolita Correia
Published: April 2020

Ao assumir o conceito de estratégia como o de direção para atingir objetivos (MINTZBERG; AHLSTRAND; LAMPEL, 2010), sua adoção se constitui como relevante para qualquer tipo de instituição (MOORE, 2000). É pertinente compreender o modo como uma instituição concebe e trabalha suas estratégias e nesse âmbito emergem as Universidades, marcadas pela complexidade e multifuncionalidade (CUNHA, 1996). Assim sendo, este é um estudo de caso com abordagem qualitativa, cujo objetivo é o de compreender como se deu o processo de formação das estratégias em um Programa de Pós-Graduação em Administração no Brasil, desde a sua criação em 1994 até os seus vinte anos em 2014. Para tanto, empregou-se o modelo proposto por Pettigrew (1987) que se apoia em três dimensões básicas aonde foram descritas as principais fases da trajetória do Programa de pós-graduação abordado, atentando para as razões que levaram à mudança (contexto), como elas ocorreram (processo) e quais as estratégias que foram implementadas (conteúdo) no período analisado. Os resultados indicaram que o processo de formação das estratégias recebeu considerável influência das mudanças provocadas pelo contexto externo, o processo se mostrou deliberado e emergente.
Resenha Bibliográfica
Authors: Söllinger Marcos Elói
Published: April 2020

A administração muitas vezes é rotulada por ater-se ao estudo das organizações sob uma visão econômica, pela óptica do lucro, da estratégia e da performance. No mais recente livro lançado pelo pesquisador e sociólogo italiano Antonio Strati, encontramos uma perspectiva que foge ao mainstream, e que possibilita lançar olhares que pouco se preocupam com números e cifras, mas que exploram elementos como a imaginação e a criatividade.
Clima organizacional sob a perspectiva dos gestores de Instituições Federais de Ensino: uma investigação multivariada
Authors: Mattos Carlos André Corrêa de
Published: April 2020

O objetivo deste estudo foi avaliar o clima organizacional segundo a percepção de gestores de Instituições Federais de Ensino Superior. A metodologia foi exploratória e descritiva, realizada na forma de levantamento, com amostragem não probabilística por acessibilidade. A amostra contou com 74 servidores públicos em cargo de gestão e o tratamento de dados foi quantitativo. A análise fatorial revelou três fatores, que explicaram 71,67% da variância dos dados e foram denominados como: Imagem e Desempenho Organizacional (32,43%), Cooperação e Integração (22,69%) e Carreira e Oportunidades (16,60%). A análise de agrupamentos classificou os entrevistados em quatro grupos, diferenciados principalmente pela Cooperação e Integração. Os grupos tiveram diferentes avaliações do ambiente organizacional, contudo 34% dos entrevistados avaliaram o clima como favorável nos três fatores. O estudo permitiu concluir que os gestores analisam o clima sob uma perspectiva estratégica, confirmando, em certa medida, a visão diferenciada desses profissionais o que justifica o destaque dado aos gestores nas avaliações de clima organizacional.
Trust between the state and business as factor of innovative development of the economy
Authors: Sotnikov Anton
Published: April 2020

The article presents the results of a study conducted by the author on the impact of trust between business and the state on the innovative development of the economy. A brief description of the phenomenon under consideration in the Russian Federation is given, and the main problems in the relationships of these entities are shown using specific examples. The crisis of confidence entails significant risks for the business, which in turn leads to a reduction in business activity and the outflow of capital. Overcoming this crisis is not possible with short-term targeted measures, since it is necessary to apply a long-term programmatic approach that combines various measures and mechanisms, as well as the interaction of the parties. The author, including, based on international experience, shows the mechanisms by which it is possible to structure relations between the government and the business community. According to the author, various measures, both general and specific, contribute to the improvement of the investment climate. The author sees the judicial system independent of the state as the main guarantee. Also, the article discusses issues of legislative guarantees of investments, providing for full compensation for damage when changing state policy in relation to specific types of activities; the introduction of public-private partnership models to address socially significant projects that are not of commercial interest to firms in the absence of state support; creation and functioning of entrepreneurial innovation infrastructure for the development of innovative firms through the combined efforts of state authorities and local self-government; improvement of civil society institutions and public discussion of the activities of state institutions and entrepreneurs.
The most important stages in the formation of a consumer cooperation system
Authors: Arustamov Eduard , Pakhomkin Andrey
Published: April 2020

This article attempts to analyze the stages of the formation and development of the cooperative movement in Russia, one of the most important sectors of the economy in which the most important activities are carried out to meet the needs of the rural population. Consumer cooperation in Russia has a nearly two-century history. During this period of its diversified activity, both positive and negative trends are clearly visible. However, despite this, consumer cooperation has maintained its identity, regardless of the political and economic changes in the country. Currently, consumer cooperation in Russia is a diversified economic organization, integrated into a market economy, which does not exclude its fulfillment of a significant amount of social functions.
The problem of conservation of strategic groundwater resources in the Moscow region
Authors: Levakova Irina , Arustamov Eduard
Published: April 2020

Тhe article deals with some features of groundwater as an object of legal regulation. The article analyzes the trends in the development of regional legislation, considers legislative acts on the procedure of registration of underground water use for legal entities and individuals. Еxamples of the activities of regional environmental supervision, the facts of the lack of full control over water production are given. Proposals are made to develop a set of measures aimed at preserving groundwater, to streamline groundwater production.
Hepatitis B Surface Antigen Positivity Is an Independent Unfavorable Prognostic Factor in Diffuse Large B-Cell Lymphoma in the Rituximab Era
Authors: Cheng Chieh-Lung , Huang Sheng-Chuan , Chen Jia-Hong , Wei Chao-Hung , Fang Wei-Quan , Su Tung-Hung , Yuan Chang-Tsu , Liu Jia-Hau , Chuang Ming-Kai , Tien Hwei-Fang
Published: April 2020

Background

Patients with diffuse large B-cell lymphoma (DLBCL) with concurrent hepatitis B surface antigen (HBsAg)-positive hepatitis B virus (HBV) infection have distinct clinical features. Nevertheless, the prognostic value of HBsAg in DLBCL in the rituximab era remains unclear.

Materials and Methods

We conducted a retrospective cohort study to investigate the clinical relevance of HBsAg in immunocompetent patients with DLBCL treated with homogeneous rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone between 2002 and 2016.

Results

Among 416 analyzed patients, 98 (23.6%) were HBsAg positive. HBsAg positivity was associated with a younger age and more advanced stage at diagnosis, more frequent hepatic impairment during perichemotherapy, and a trend of higher National Comprehensive Cancer Network-International Prognostic Index (NCCN-IPI) score at diagnosis. Compared with the HBsAg-negative patients, the HBsAg-positive patients had a lower overall response rate (76.5% vs. 85.5%, p = .043), poorer 5-year overall survival (OS) rate (57.2% vs. 73.5%, p < .001), and shorter 5-year progression-free survival (PFS) rate (47.2% vs. 60.7%, p = .013). Multivariate analyses showed that HBsAg positivity was an independent unfavorable prognostic indicator for OS and PFS. A scoring system incorporating HBsAg positivity, the NCCN-IPI score, and serum albumin levels proved to be useful for stratifying prognostically relevant subgroups of patients with DLBCL.

Conclusion

This study demonstrated that HBV infection is uniquely relevant to DLBCL. HBsAg might serve as a novel biomarker to improve clinical risk stratification of patients with DLBCL in areas with high prevalence of HBV infection. Further research investigating the etiopathogenesis of HBV infection in DLBCL is imperative.

Implications for Practice

A considerable disparity exists regarding the prognostic relevance of hepatitis B surface antigen (HBsAg)-positive hepatitis B virus (HBV) infection in patients with diffuse large B-cell lymphoma (DLBCL). In this large, retrospective cohort study from an area with high prevalence of HBV infection, the authors demonstrated that HBsAg was an independent unfavorable factor significantly associated with survival, highlighting its potential as a novel prognostic indicator to improve the risk stratification of patients with DLBCL in the rituximab era.
2018-2019 SEZONU SPOR TOTO SÜPER LİGDE REKABETÇİ DENGE
Authors: GÖRÜN Levent
Published: April 2020

Bu çalışma Spor Toto Süper Ligi 2018-2019 sezonu
rekabetçi denge düzeyini ölçmeyi amaçlamaktadır. Bu araştırma betimsel bir
araştırma modelidir. Spor Toto Süper Ligin rekabetçi denge düzeyini ölçmek için
tarama modelinden yararlanılmış ve doküman analizi yöntemi kullanılmıştır.
Doküman analizinde 2018-2019 sezon sonu tabloları kullanılarak rekabetçi
dengenin ölçülmesi için C5 endeksi, Herfindahl-Hirschman İndeksi, Lorenz Egrisi
ve Gini Katsayısı kullanılmıştır. Araştırma sonucunda ligin rekabetçi dengesini
ölçmek için kullanılan C5 endeksi değeri 0,31 çıkmıştır. Lig sıralaması baz
alındığında Herfindahl-Hirschman değeri 105,3 elde edilmiştir. Gini değeri ise
yapılan hesaplamalara göre 0,13 çıkmıştır. Bu değerler 2018-2019 sezonunda Spor
Toto Süper Liginde rekabetçi dengeye yakın bir sonuç ortaya koymaktadır.
RNA Extraction Without a Kit v1
Authors: The Nonprofit Plasmid Repository Addgene
Published: April 2020

This protocol describes RNA extraction without a kit. To see the full abstract and additional resources, visit https://www.addgene.org/protocols/kit-free-rna-extraction/
DAB Solutions v5
Authors: Institute for Brain Science Allen
Published: April 2020

3, 3´ Diaminobenzidine (DAB) is a commonly used chromogen for histological staining. In the presence of peroxidase enzyme, DAB produces a brown precipitate that is insoluble in alcohol and xylene. Peroxidase catalyzes hydrogen peroxide oxidation of substrate DAB. This SOP provides instructions to prepare four different formulations of DAB. DAB for Immunohistochemical staining (IHC), DAB for Acetylcholinesterase (AChE) Staining, Nickel Enchanced DAB for Biocytin staining, and DAB for Biocytin staining. Note: Research reported in this publication was supported by the National Institute Of Mental Health of the National Institutes of Health under Award Number U19MH114830. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Farklı Spor Dallarında Spor ve Enerji İçeceklerinin Kullanımı ve Performansa Etkileri
Authors: TURNAGÖL Hüsrev , AKTİTİZ Selin , KORUR Derya Canan , KURU Dilara
Published: April 2020

Sporcularda sıvı dengesinin sağlanamaması ve glikojen depolarının tükenmesi, yorgunluğa neden olarak performansı olumsuz etkilemektedir. Yorgunluğun azaltılarak optimal spor performansının sağlanabilmesi için çeşitli beslenme stratejileri geliştirilmiştir. Spor içecekleri hem sıvı dengesinin korunmasına yardımcı olarak dehidrasyonu önlediği, hem de egzersiz anında substrat ve elektrolit desteği sağladığı için egzersiz yapan bireyler tarafından yaygın olarak kullanılan beslenme destekleridir. Spor içecekleri temel olarak içerisinde az miktarda karbonhidrat (6-8 g/100 ml) ve elektrolit (sodyum, potasyum, kalsiyum, magnezyum) içeren ürünlerdir. Kullanım amacına göre farklı içeriklere sahiptirler. Spor içeceklerine alternatif olarak sunulan enerji içecekleri ise yüksek miktarda karbonhidratla birlikte kafein gibi bir takım ergojenik destekler içeren ürünlerdir. Bu içecekler, dikkat algısını ve mental uyanıklığı geliştirmeyi hedeflemektedir. Bu derlemede, spor ve enerji içeceklerinin türleri ve bunların farklı spor dallarında kullanım amaçları ve performansa etkileri incelenmiştir. Branşa ve/veya amaca özgü olarak spor içeceklerinin tüketimi; hidrasyonu ve elektrolit dengesinin sağlanmasını, karbonhidrat depolarının yenilenmesini, protein alımı ile kas hasarının önlenmesini ve kas protein sentezinin arttırılmasını sağlayarak spor performansını ve toparlanmayı olumlu etkilemektedir. Ancak enerji içeceklerinin, yüksek karbonhidrat konsantrasyonuna sahip olmaları nedeniyle, egzersiz sırasında substrat kaynağı olmaya ve rehidrasyon sağlamaya uygun olmadıkları belirlenmiştir. Ayrıca kuvvet sporlarında güç/kuvvet kazanımına olası olumlu etkisinin dışında diğer spor branşlarında performansa etkisinin net ortaya konulamadığı ve daha fazla çalışmaya ihtiyaç olduğu görülmüştür.
Institutionalization of Constitutional Norms in the Dynamics of the Subject Matter of the Legal Regulation
Authors: Taeva N. E.
Published: April 2020

In the paper based on conceptual provisions put forward by Prof. Kozlova, the author sets the objective to identify tendencies that manifest themselves in the development of constitutional and legal institutions at the present stage taking into account the dynamics of the subject of legal regulation, as well as the ongoing transformation of the Russian legal system. In this regard, the author has examined the problem of expanding the field of relations regulated under constitutional law. The author has concluded about the blurring of boundaries between institutions of constitutional law, which entails the problem of attribution of norms to a particular institution. The paper has analyzed the issue of emergence of intersectoral institutions that can be characterized as neither public nor private, as neither substantive nor procedural. This leads to the need to change the very approach to the concept of “institution of law.” It is concluded that constitutional law institutions can contain unwritten legal regulators that can include both rules of natural law and rules of conduct developed directly in the society.
“The Subject Matter of the Branch Gets its Actual Expression in the System:” Prof. Ekaterina I. Kozlova about the System of Constitutional Law and its Institutions
Authors: Kononov K. A.
Published: April 2020

The paper has analyzed the academic heritage of Prof. Ekaterina I. Kozlova in the part of her research of fundamental issues of the theory of constitutional (state) law, namely: the system of the branch under consideration and public law institutions. The author focuses on suggested by Prof. Ekaterina I. Kozlova innovative division of the system of the branch of constitutional law and the structure of the Constitution, the substantive approach to the construction of the institution of state law, consistent defense of the concept of unity of the system of constitutional (state) law. The author has determined the current significance of the conclusions made by Prof. Ekaterina E. Kozlova concerning the development of constitutional law institutions: complication of their structure, expansion and specialization of constitutional law norms and, as a consequence, the emergence of complex institutions and the problem of subsectors; an increase in the number of norms, i.e. principles and procedural rules in constitutional law.
Evolution of Representative Bodies in Russia
Authors: Osavelyuk A. M.
Published: April 2020

The paper based on the analysis of the provisions of the Constitution of the RSFSR of 1918, the Constitution of the USSR of 1936, the Constitution of the USSR of 1977 shows the basic principles of organization and activity of the Soviets as representative authorities of the Soviet State. The author has analyzed research papers, primarily research papers and studies by Prof. Ekaterina I. Kozlova explaining the main stages and features of evolution of the essence and activity of the Soviets at all levels of the State. Also, the author has examined the shortcomings of the legal status and functioning of domestic representative bodies of state power — the Soviets — during the Soviet period.

The study has demonstrated that with the adoption of the Constitution of Russia in 1993 , the Russian Federation witnessed the development of a fundamentally new, democratic stage of development of representative bodies of state power, as well as local self — government, based on the principles of democracy, separation of powers, federalism, autonomy of local self — government and its representative bodies.

Having analyzed Prof. Kozlova research papers, the author has come to the conclusion that even on the example of her research of one of the most important institutions of the state — representative bodies of state power and local self-government in the Russian Federation — Prof. Kozlova made an outstanding contribution to the development of the science of constitutional law of Russia.
Modern Mechanisms of Formation, Identification and Protection of the Will of the People
Authors: Komarova V. V.
Published: April 2020

The paper analyzes the academic legacy of Prof. Ekaterina I. Kozlova in the part of her research of fundamental issues of the theory of democracy and various forms of its manifestation and mechanisms of implementation. Over the years of her academic career Ekaterina I. Kozlova researched the evolution of the conceptual foundations of democracy in the Russian Federation, and the will of the people is the quintessence of it. The basic ideas of Prof. Kozlova are manifested in both the modern doctrine of constitutional and municipal law and jurisprudence. The paper investigates the local community as a way of formation and identification of the will of residents of the municipality. The author has elucidated the modern development of ideas of people’s representation in the concept of representative democracy, municipal and public representation and substantiated the idea, structure and content of the public power. The development of the society and scientific and technological progress create new risks, which require new mechanisms and updating of existing ones. With this regard, the author has investigated ideas of modern authors concerning “people’s accusation”.
Administrative Procedural Status of Participants in Disciplinary Proceedings
Authors: Leshchina E. L.
Published: April 2020

The paper examines the legal status of participants in disciplinary proceedings, identifies and analyzes the existing points of view on their classification. Having brought together a number of approaches, the author proposes to classify participants in disciplinary proceedings on the following grounds: 1) according to their functional role in production; 2) depending on the obligatory nature of their participation in production; 3) depending on the interest of participants in the disciplinary proceedings in its results. The following is a description of the administrative and procedural status of participants in proceedings in disciplinary cases. The author substantiates proposals for improving the legal status of a civil servant in respect of which disciplinary proceedings are carried out. It is concluded that disciplinary proceedings as a whole are a means of realizing the legitimate interest of its participants. In conclusion, the author expresses the opinion that the current state of legal regulation of the legal status of participants in disciplinary proceedings in the civil service system of the Russian Federation in the context of incomplete reform of the civil service institution is far from being perfect.
Intellectual Property in the Age of 3D Printing
Authors: Churilov A. Yu.
Published: April 2020

The paper discusses the features of three-dimensional printing and the innovations that it brought to the field of copyright, industrial property rights, in particular industrial design, and means of individualization. The concept and some features of three-dimensional printing technology are disclosed. The author studies the exclusive rights to which results of intellectual activity can be violated when using the technology of three-dimensional printing. It is concluded that exclusive rights to an industrial design, trademarks, and to copyright may be violated. The author investigates the actions that will not constitute a violation of the exclusive right to the considered results of intellectual activity. It is concluded that not every action would constitute a violation of exclusive rights, in particular, this applies to the use of a trademark for purposes not related to the introduction of goods into circulation; use of industrial design for purposes not related to the implementation of entrepreneurial or other income-generating activities.
The Specifics of the Legal Regime of the Civil Legal Relations Objects Functioning (Theoretical Aspect)
Authors: Tereshchenko D. S.
Published: April 2020

The paper analyzes the current state of development of the concept of the legal regime and its features in the legal literature. It is indicated that the key phrase “regulatory procedure” is not fully consistent with the definition of the legal regime. Wider approaches to understanding the phenomenon of the concept of “legal regime” in the form of a functional characteristic of the operation of law are proposed. It is noted that to describe the features of the legal regime, researchers often and haphazardly use individual qualitative characteristics that do not fully reveal the meaning of the definitions of both the legal regime and its individual attributes. The author clarifies the difference between the characteristics of “special” and “particular”, “specialized” and “specific” in relation to civil legal relations. The conclusion is drawn on the need for legislative consolidation of the revealed differences and the establishment of two types of legal regimes — the legal regime of activity and the legal regime of the operation of an object. Based on the conducted structural study, the author formulates the definitions for the legal regime and civil law regime.
Beden Değeri Ölçeği-2’nin (BDÖ-2) Türkçe Adaptasyonu: Geçerlik ve Güvenirlik Çalışması
Authors: OKTAN Vesile , SAYLAN Ezgi
Published: April 2020

Bu çalışmanın amacı, Tylka ve Wood-Barcalow (2015) tarafından bireylerin kendi bedenlerine yönelik ne derece olumlu düşünceleri olduğunu ve bu düşüncelere saygı duyup duymadıklarını değerlendirmek amacıyla geliştirilmiş olan Beden Değeri Ölçeği-2 (BAS-2)’nin faktör yapısını incelemektir. Beden Değeri Ölçeği-2, 5’li Likert türü bir ölçme aracı olup 10 maddeden oluşmaktadır. Beden Değeri Ölçeği-2’nin faktör yapısı, 15-24 yaş aralığındaki kadın ve erkek bireylerden oluşan 649 kişilik çalışma grubu üzerinde incelenmiştir. Ölçeğin faktör yapısını ortaya koymak üzere açımlayıcı ve doğrulayıcı faktör analizi yapılmıştır. Geçerlik ve güvenirlik analizleri için IBM SPSS Statistics v20.0 ve Lisrel 8.80 programları kullanılmıştır. Güvenirlik analizlerinde Cronbach alfa iç tutarlık katsayısı tekniğinden faydalanılmıştır ve ölçeğin genel güvenirliği .90 olarak bulunmuştur. Faktör analizi sonuçları ölçeğin özgün formunda olduğu gibi tek boyutlu bir yapıda olduğunu ortaya koymuştur. Analiz sonuçları, Beden Değeri Ölçeği-2’nin Türk genç ve genç yetişkinler üzerinde yeterli düzeyde geçerlik ve güvenirlik değerlerine sahip olduğunu ve bireylerin bedenlerine yönelik algılarını değerlendirmede geçerli ve güvenilir bir araç olarak kullanılabileceğini göstermiştir.
Öğretmen Adaylarının Kültürlerarası Duyarlılıklarının Empatik Eğilim, Öznel İyi Oluş ve Sosyo-Demografik Değişkenler Açısından İncelenmesi
Authors: BÖLÜKBAŞI Ayten
Published: April 2020

Bu araştırmanın amacı öğretmen adaylarının empatik eğilim ve öznel iyi oluş puanlarının kültürlerarası duyarlılık puanlarını yordamadaki katkılarını inceleyerek kültürlerarası duyarlılık puanlarının cinsiyet, öğrenim gördükleri program, yurtdışı deneyimi, algılanan yabancı dil düzeyi, farklı ülke ya da kültürlerden tanıdıklara ve yakın arkadaşlara sahip olma sosyo-demografik değişkenleri açısından farklılaşıp farklılaşmadığını incelemektir. Araştırmanın çalışma grubunu, Akdeniz Bölgesindeki bir devlet üniversitesinin eğitim fakültesinin farklı programlarından 253’ü (%71.3) kadın ve 102’si (%28.7) erkek olmak üzere toplam 355 öğretmen adayından oluşmaktadır. “Kültürlerarası Duyarlılık Ölçeği”, “Empatik Eğilim Ölçeği”, “Yaşam Doyumu Ölçeği”, “Olumlu-Olumsuz Duygu Ölçeği”, “Kişisel Bilgi Formu” kullanılarak toplanan verilerin analizinde korelasyon analizi, çoklu regresyon analizi, bağımsız gruplar için t-testi, tek yönlü varyans analizi kullanılmıştır. Araştırmanın veri analizi sonuçlarına göre, öğretmen adaylarında kültürlerarası duyarlılık, empatik eğilim ve öznel iyi oluş arasında pozitif yönlü anlamlı ilişkiler tespit edilmiştir. Ayrıca, empatik eğilim ve öznel iyi oluşun, kültürlerarası duyarlılığın anlamlı birer yordayıcısı olduğu ortaya konulmuştur. Sosyo-demografik değişkenler açısından ise öğretmen adaylarında kültürlerarası duyarlılıkta cinsiyete göre anlamlı farklılaşma tespit edilmezken öğrenim gördükleri program, yurtdışı deneyimi, algılanan yabancı dil düzeyi, farklı ülke ya da kültürlerden tanıdıklara ve yakın arkadaşlara sahip olma değişkenleri açısından anlamlı farklılaşma tespit edilmiştir.
SOBRE VIVÊNCIAS NEGOCIADAS: INDÍGENAS E JESUÍTAS FRANCESES NO OIAPOQUE SETECENTISTA
Authors: Nascimento Bruno Rafael Machado , Silva Giovani José da
Published: April 2020

O objetivo do artigo é compreender as relações entre indígenas e jesuítas na região do rio Oiapoque, atual fronteira entre Brasil e França, no Norte da América do Sul, na primeira metade do século XVIII (principalmente na margem esquerda, ou seja, na Guyane, território considerado francês). Busca-se analisar agências dos nativos frente à catequese dos missionários franceses, a partir de cartas escritas pelos padres, publicadas no século XIX. Navegar nos rios, furos e igarapés da Amazônia exigia conhecimentos específicos, cujos detentores eram os indígenas, considerados “selvagens”. Os missionários, tanto da colônia portuguesa quanto da francesa, por exemplo, dependiam deles e os pilotos e guias experientes eram valorizados e buscavam usar estratégias de negociação com os agentes coloniais, para sobreviver física e culturalmente. Dessa forma, os indígenas são percebidos como agentes do processo histórico, protagonistas de suas próprias histórias e não apenas vítimas da colonização e do contato com europeus.
L’apport des techniques à haut débit (protéomique et transcriptomique) dans l’identification et la caractérisation fonctionnelle des protéines de l’œuf
Authors: GAUTRON J. , REHAULT-GODBERT S. , JONCHERE V. , HERVE-GREPINET V. , MANN K. , NYS Y.
Published: April 2020

L’œuf de poule est le lieu de développement de l’embryon, mais aussi un aliment de base et une source importante de molécules dotées d’activités biologiques largement utilisées en santé humaine et dans les industries agroalimentaires, cosmétiques et pharmaceutiques. L’identification des protéines de l’œuf initialement réalisée par des techniques classiques de biochimie, a connu un essor considérable grâce aux développements d’outils d’analyse à haut débit, la publication de la séquence génomique de la poule et l’essor de la bioinformatique. Dans cette revue, nous décrirons quel est l’apport de la génomique fonctionnelle et comment l’analyse transcriptomique et protéomique constituent des avancées majeures dans la connaissance des protéines de l’œuf. Ces avancées ont permis en quelques années l’identification et la caractérisation dans les différents compartiments de l’œuf de centaines de nouveaux composés aux fonctions riches et variées. Des études expérimentales supplémentaires seront nécessaires pour explorer les fonctions des composés nouvellement identifiés dans l’œuf. Ces nouvelles molécules constituent potentiellement des composés biologiquement actifs aux propriétés bénéfiques pour l’Homme ou l’animal. Certains de ces composés pourront être utilisés comme marqueurs biologiques dont le polymorphisme d’un nucléotide simple (SNP) permettra de développer une Sélection Assistée par Marqueurs (SAM) pour améliorer les défenses naturelles de l’œuf et réduire le risque de toxi-infections alimentaires humaines.
Domain Specific Assets: A Software Platform for Use Case Driven Human Friendly Factory Interaction
Authors: Brandt Felix , Brandt Eric , Ghofrani Javad , Heik David , Reichelt Dirk
Published: April 2020

In current efforts to digitize manufacturing and move it into the fourth stage of the industrial revolution, a wide range of integration solutions is being considered to enable manufacturing to adapt to change. In transforming a factory into a self-organized, autonomous factory, companies are currently struggling with rapidly changing requirements and production factors, among other things. This is a particular problem for the human being as an actor within the factory, as the amount of new technologies and protocols increases the training effort. Proprietary interfaces of the control providers, a wide range of different communication protocols, complicate the understanding of the production processes, the evaluation and testability of new use cases and increase the danger of creating silos of knowledge as well as building collaboration barriers. As a solution to these problems, we propose an open software platform and define a way to model use case driven domain specific asset representation (DSA) that focuses on the human being and his needs for representing the factory in a way that it meets his requirements for the current production needs. We therefore conducted research on google scholar on human factors in industry 4.0 and used technologies as well as already existing platforms and their architecture.
Anterior Cruciate Ligament Retensioning—A Novel Revision Procedure Using Suture Augmentation
Authors: Shu Henry T. , Day Jonathan , Bodendorfer Blake M. , Argintar Evan H.
Published: April 2020

Case:

We report the case of a 44-year-old woman with previous anterior cruciate ligament (ACL) reconstruction 25 years ago in the right knee, who sustained a bucket-handle medial meniscus tear after pain and instability while pivoting during tennis. Magnetic resonance imaging demonstrated an intact but vertical and anterior ACL graft. A novel ACL retensioning procedure with suture augmentation (SA) was performed as the revision procedure. Excellent clinical outcomes and knee stability were obtained at both 17 and 36 months postoperatively.

Conclusions:

In certain cases, ACL retensioning with SA may be performed as the revision procedure for unsuccessful primary ACL reconstruction.
Mechanism of Wnt Pathway on Cartilage Differentiation of Adipose-Derived Stem cells
Authors: Dai Wanwu , Zhang Bo , Huang Zuquan , Sun Guili , Yang Yejing , Cai Min , Feng Zhe , Li Xingyan
Published: April 2020

Background: Adipose-derived stem cells ( ADSCs ) therapy is considered as a promising alternative to treat osteoarthritis (OA).Considerable evidence has shown that the Wnt signaling pathway is involved in chondrogenic differentiation in various stem cells.In the present study, we explored in detail the mechanism of of Wnt signaling pathway in the regulation of adipose-derived stem cell chondrogenic differentiation.Methohs: Adipose-derived stem cells were extracted from Sprague-Dawley groin area, isolated, cultured and verified. Then LiCl and DKK-1 used to induce ADSCs cartilage differentiation to detect indicators of cartilage at different stages, such as collagen type II (Collagen2a), aggrecan (Aggrecan) and Wnt pathway key proteins Sox9, β-catenin, Glycogen synthase kinase-3β (GSK-3β) expression.Subsequently, lentivirus was used as the vector, the full-length Sox9 gene was transfected into ADSCs and the expression levels of relevant indicators were detected again after stable expression.Results: In the process of inducing differentiation, the Wnt pathway promoted the rapid proliferation of ADSCs in the early, middle and late stages, and up-regulates Sox9 expression.Cartilage indicators Collagen 2a and Aggrecan expression levels were not significantly increased in the early stage, but significantly increased in the middle and late stages (P <0.05). At the later stage, however, the Wnt pathway down-regulated Sox9 expression, weakened the mature cartilage phenotype, promoted cartilage hypertrophy and early cartilage ossification. Finally, the overexpression of Sox9 feedback inhibits the Wnt pathway activity, down-regulates β-catenin expression, maintains cartilage phenotype, delays cartilage hypertrophy and early osteogenesis.Conclusion:The Wnt pathway regulates chondrogenic differentiation of ADSCs by regulating Sox9, but its regulatory mechanism is significantly different at different stages of induced differentiation.
Analysis of the mental health status and risk factors of the general population in Beijing, China: A cross-sectional study
Authors: XIE YUJIN , Shi Lei , Liu Ying , Liu Di , Jiao Yang , Yu Hong
Published: April 2020

Background This study sought to understand the mental health status of Beijing’s general population, analyze the risk factors that affect it, and provide a scientific basis for promoting the physical and mental health of the general population. Methods A cross-sectional design was used. Overall sampling was used to select 6,364 people who had undergone a physical examination from January to December 2018 and volunteered to participate in an assessment of their mental health. We used the SCL-90 to establish the current normal mental health model of the general population in Beijing. After using the PEM System to export and automatically generate Excel files, SPSS 19.00 was utilized for statistical analysis. Descriptive statistical analysis methods were used to analyze the mental health status of the respondents and the mean and standard deviation of each factor. A t-test was used to compare the mental health of the general population in Beijing with the Chinese norm in 1986. Multiple linear regression analysis was used to explore the influencing factors of the mental health of the general population in Beijing. Results The average score of each factor of the SCL-90 in Beijing's general population was between 1.28 and 1.75, with no significant peaks. The scores of various factors in the general population in Beijing were relatively close, and their mental health remained stable. The analysis of the demographic variables of gender, education, age, marital status, and monthly income showed that monthly income ( β=-0.027, p<0.05) and gender ( β=-0.026,p<0.05) had significant effects on the SCL-90 score of the general population. Conclusion The mental health level of Beijing’s general population was lower than the Chinese norm in 1986. Male mental health problems were prominent and low-income people were prone to psychological problems. It is imperative to strengthen the construction of a mental health service system and standardized management among the Chinese population. Strengthening the popularization of mental health knowledge, guiding the Chinese population to cultivate a positive attitude, preventing bad attitudes, encouraging the use of scientific methods to deal with psychological behavioral problems, and early targeted measures can reduce the occurrence of serious psychological problems.
Orlistatand and Rosuvastatin Suppressed Proliferation of K562 Human Myelogenous Leukemia Cell Line through AMPK/Akt/c-Myc Signaling
Authors: Mojjarad Behnam , Pazhang Yaghub
Published: April 2020

The authors have withdrawn this preprint due to erroneous posting.