bluuebunny/crossref_metadata_2025 huggingface dataset:
Dosimetric impact of orthopedic metal artifact reduction (O‐MAR) on spine SBRT patients
Authors: Shen Zhilei Liu , Xia Ping , Klahr Paul , Djemil Toufik
Published: February 2017

The dosimetric impact of orthopedic metal artifact reduction (O‐MAR) on spine SBRT patients has not been comprehensively studied, particularly with spinal prostheses in high‐dose gradient regions. Using both phantom and patient datasets, we investigated dosimetric effects of O‐MAR in combination of various metal locations and dose calculation algorithms. A physical phantom, with and without a titanium insert, was scanned. A clinical patient plan was applied to the artifact‐free reference, non‐O‐MAR, and O‐MAR phantom images with the titanium located either inside or outside of the tumor. Subsequently, five clinical patient plans were calculated with pencil beam and Monte Carlo (iPlan) on non‐O‐MAR and O‐MAR patient images using an extended CT‐density table. The dose differences for phantom plans and patient plans were analyzed using dose distributions, dose‐volume histograms (DVHs), gamma index, and selected dosimetric endpoints. From both phantom plans and patient plans, O‐MAR did not affect dose distributions and DVHs while minimizing metal artifacts. Among patient plans, we found that, when the same dose calculation method was used, the difference in the dosimetric endpoints between non‐O‐MAR and O‐MAR datasets were small. In conclusion, for spine SBRT patients with spinal prostheses, O‐MAR image reconstruction does not affect dose calculation accuracy while minimizing metal artifacts. Therefore, O‐MAR images can be safely used for clinical spine SBRT treatment planning.

PACS numbers: 87.53.Bn, 87.55.K‐, 87.57.Q‐, 87.57.cp
Late radiation toxicity in Hodgkin lymphoma patients: proton therapy's potential
Authors: Toltz Allison , Shin Naomi , Mitrou Ellis , Laude Cecile , Freeman Carolyn R. , Seuntjens Jan , Parker William , Roberge David
Published: February 2017

In 2010, all young patients treated for intrathoracic Hodgkin lymphoma (HL) at one of 10 radiotherapy centers in the province of Quebec received 3D conformal photon therapy. These patients may now be at risk for late effects of their treatment, notably secondary malignancies and cardiac toxicity. We hypothesized that more complex radiotherapy, including intensity‐modulated proton therapy (IMPT) and possibly IMRT (in the form of helical tomotherapy (HT)), could benefit these patients. With institutional review board approval at 10 institutions, all treatment plans for patients under the age of 30 treated for HL during a six‐month consecutive period of 2010 were retrieved. Twenty‐six patients were identified, and after excluding patients with extrathoracic radiation or treatment of recurrence, 20 patients were replanned for HT and IMPT. Neutron dose for IMPT plans was estimated from published measurements. The relative seriality model was used to predict excess risk of cardiac mortality. A modified linear quadratic model was used to predict the excess absolute risk for induction of lung cancer and, in female patients, breast cancer. Model parameters were derived from published data. Predicted risk for cardiac mortality was similar among the three treatment techniques (absolute excess risk of cardiac mortality was not reduced for HT or IMPT () as compared to 3D CRT). Predicted risks were increased for HT and reduced for IMPT for secondary lung cancer () and breast cancers () as compared to 3D CRT.

PACS numbers: 87.55.dh, 87.55.dk
Superiority of a soft tissue‐based setup using cone‐beam computed tomography over a bony structure‐based setup in intensity‐modulated radiotherapy for prostate cancer*
Authors: Sato Hiraku , Abe Eisuke , Utsunomiya Satoru , Kaidu Motoki , Yamana Nobuko , Tanaka Kensuke , Ohta Atsushi , Obinata Mika , Liu Junyang , Kawaguchi Gen , Maruyama Katsuya , Ayukawa Fumio , Aoyama Hidefumi
Published: February 2017

The purpose of this study was to test the superiority of a soft tissue‐based setup using cone‐beam computed tomography (CBCT) to a bony structure‐based setup using the ExacTrac system in intensity‐modulated radiotherapy (IMRT) for prostate cancer. We studied 20 patients with localized prostate cancer who received IMRT between November 2010 and February 2012. After the initial setup, the pelvic bony structure‐based setup and ExacTrac system were applied. After that, CBCT and a soft tissue‐based setup were used. A shift in the isocenter between the ExacTrac‐based and CBCT‐based setup was recorded in the anterior–posterior (AP), superior–inferior (SI), and left–right (LR) axes. The shift was considered an interfractional prostate shift. Post‐treatment CBCT was also taken once a week to measure the intrafractional prostate shift, based on the coordinates of the isocenter between pre‐ and post‐treatment CBCT. The planning target volume (PTV) margins were determined using van Herk's method. We measured the elapsed time required for soft tissue matching and the entire treatment time using CBCT. The of the inter‐ and intrafractional shifts were and in the AP, and in the SI, and and in the LR directions. The PTV margins in the cases of bony structure‐based and soft tissue‐based setups were 7.3 mm and 2.7 mm in the AP, 5.8 mm and 2.3 mm in the SI, and 1.9 mm and 1.2 mm in the LR directions. Even though the median elapsed time using CBCT was expanded in 5.9 min, the PTV margins were significantly reduced. We found the calculated PTV margins in the soft tissue‐based setup using CBCT were small, and this arrangement was superior to the bony structure‐based setup in prostate IMRT.

PACS numbers: 87.19.ru, 87.55.T‐
Evaluation of backscatter dose from internal lead shielding in clinical electron beams using EGSnrc Monte Carlo simulations
Authors: de Vries Rowen J. , Marsh Steven
Published: February 2017

Internal lead shielding is utilized during superficial electron beam treatments of the head and neck, such as lip carcinoma. Methods for predicting backscattered dose include the use of empirical equations or performing physical measurements. The accuracy of these empirical equations required verification for the local electron beams. In this study, a Monte Carlo model of a Siemens Artiste linac was developed for 6, 9, 12, and 15 MeV electron beams using the EGSnrc MC package. The model was verified against physical measurements to an accuracy of better than 2% and 2 mm. Multiple MC simulations of lead interfaces at different depths, corresponding to mean electron energies in the range of 0.2–14 MeV at the interfaces, were performed to calculate electron backscatter values. The simulated electron backscatter was compared with current empirical equations to ascertain their accuracy. The major finding was that the current set of backscatter equations does not accurately predict electron backscatter, particularly in the lower energies region. A new equation was derived which enables estimation of electron backscatter factor at any depth upstream from the interface for the local treatment machines. The derived equation agreed to within 1.5% of the MC simulated electron backscatter at the lead interface and upstream positions. Verification of the equation was performed by comparing to measurements of the electron backscatter factor using Gafchromic EBT2 film. These results show a mean value of to 1σ of the predicted values of electron backscatter. The new empirical equation presented can accurately estimate electron backscatter factor from lead shielding in the range of 0.2 to 14 MeV for the local linacs.

PACS numbers: 87.53.Bn, 87.55.K‐, 87.56.bd
Evaluation of detectors for acquisition of pristine depth‐dose curves in pencil beam scanning
Authors: Bäumer Christian , Koska Benjamin , Lambert Jamil , Timmermann Beate , Mertens Thierry , Talla Patrick Takoukam
Published: February 2017

Acquisition of quasi‐monoenergetic ("pristine") depth‐dose curves is an essential task in the frame of commissioning and quality assurance of a proton therapy treatment head. For pencil beam scanning delivery modes this is often accomplished by measuring the integral ionization in a plane perpendicular to the axis of an unscanned beam. We focus on the evaluation of three integral detectors: two of them are plane‐parallel ionization chambers with an effective radius of 4.1 cm and 6.0 cm, respectively, mounted in a scanning water phantom. The third integral detector is a 6.0 cm radius multilayer ionization chamber. The experimental results are compared with the corresponding measurements under broad field conditions, which are performed with a small radius plane‐parallel chamber and a small radius multilayer ionization chamber. We study how a measured depth‐dose curve of a pristine proton field depends on the detection device, by evaluating the shape of the depth‐dose curve, the relative charge collection efficiency, and intercomparing measured ranges. Our results show that increasing the radius of an integral chamber from 4.1 cm to 6.0 cm increases the collection efficiency by 0%–3.5% depending on beam energy and depth. Ranges can be determined by the large electrode multilayer ionization chamber with a typical uncertainty of 0.4 mm on a routine basis. The large electrode multilayer ionization chamber exhibits a small distortion in the Bragg Peak region. This prohibits its use for acquisition of base data, but is tolerable for quality assurance. The good range accuracy and the peak distortion are characteristics of the multilayer ionization chamber design, as shown by the direct comparison with the small electrode counterpart.

PACS number: 87.55.Qr
Determination of optimal PTV margin for patients receiving CBCT‐guided prostate IMRT: comparative analysis based on CBCT dose calculation with four different margins
Authors: Gill Sukhdeep K. , Reddy Krishna , Campbell Nina , Chen Changhu , Pearson David
Published: February 2017

Variations in daily setup and rectum/bladder filling lead to uncertainties in the delivery of prostate IMRT. The purpose of this study is to determine the optimal PTV margin for CBCT‐guided prostate IMRT based on daily CBCT dose calculations using four different margins. Five patients diagnosed with low‐risk prostate cancer were treated with prostate IMRT to 70 Gy in 28 fractions using daily CBCT for image guidance. The prostate CTV and OARs were contoured on all CBCTs. IMRT plans were created using 1 mm, 3 mm, 5 mm, and 7 mm CTV to PTV expansions. For each delivered fraction, dose calculations were generated utilizing the pretreatment CBCT translational shifts performed and dosimetric analysis was performed. One hundred and forty total treatment fractions (CBCT sessions) were evaluated. The planned prostate CTV V100% was 100% for all PTV margins. Based on CBCT analysis, the actual cumulative CTVs V100% were , and for 1, 3, 5, and 7 mm uniform PTV margins, respectively. Delivered rectum and bladder doses were different as compared to expected planned doses, with the magnitude of differences increasing with PTV margin. Daily setup variation during prostate IMRT yields differences in the actual vs. expected doses received by the prostate CTV, rectum, and bladder. The magnitude of these differences is significantly affected by the PTV margin utilized. It was found that when daily CBCT was used for soft‐tissue alignment of the prostate, a 3 mm PTV margin allowed for CTV to be covered for 99% of cases.

PACS numbers: 87.55.dk‐, 87.57.Q‐
Comparison of VMAT‐SABR treatment plans with flattening filter (FF) and flattening filter‐free (FFF) beam for localized prostate cancer
Authors: Chung Jin‐Beom , Kim Jae‐Sung , Eom Keun‐Yong , Kim In‐Ah , Kang Sang‐Won , Lee Jeong‐Woo , Kim Jin‐Young , Suh Tae‐Suk
Published: February 2017

The purpose of this study is to investigate the feasibility of using a flattening filter‐free (FFF) beam with an endorectal balloon for stereotactic ablative body radiotherapy (SABR) of clinically localized prostate cancer. We assessed plans of SABR with volumetric‐modulated arc therapy (VMAT) that used a flattening filter (FF) beam and an FFF beam and compared the verification results of dosimetric quality assurance for all pretreatment plans. A total of 20 patients with prostate cancer were enrolled in the study. SABR plans using VMAT with two full arcs were optimized in the Eclipse treatment planning system. All plans prescribed 42.7 Gy in 7 fractions of 6.1 Gy each. Four SABR plans were computed for each patient: two with FF beams and two with FFF beams of 6 and 10 MV. For all plans, the cumulative dose‐volume histograms (DVHs) for the target volumes and organs at risk (OARs) were recorded and compared. Pretreatment quality assurance (QA) was performed using the I'mRT MatriXX system and radiochromic EBT3 film to verify treatment delivery, and gamma analysis was used to quantify the agreement between calculations and measurements. In addition, total monitor units (MUs) and delivery time were investigated as technical parameters of delivery. All four plans achieved adequate dose conformity to the target volumes and had comparable dosimetric data. The DVHs of all four plans for each patient were very similar. All plans were highly conformal with and , and the doses were homogeneous (HI = 0.08–0.15). Sparing for the bladder and rectum was slightly better with the 10 MV FF and FFF plans than with the 6 MV FF and FFF plans, but the difference was negligible. However, there was no significant difference in sparing for the other OARs. The mean agreement with the criterion was higher than 97% for verifying all plans. For the criterion, the corresponding agreement values were more than 90%, which showed that the plans were acceptable. The mean MUs and delivery time used were and min for 6 MV FF, and min for 6 MV FFF, and min for 10 MV FF, and and min for 10 MV FFF, respectively. In the current study, the dose distributions of the prostate SABR plans using 6 and 10 MV FFF beams were similar to those using 6 and 10 MV FF beams. However, this study confirmed that SABR treatment using an FFF beam had an advantage with respect to delivery time. In addition, all pretreatment plans were verified as acceptable and their results were comparable. Therefore, the results of this study suggest that the use of an FFF beam for prostate SABR is a feasible and efficient technique, if carefully applied.

PACS numbers: 87.55.D, 87.55.dk
Alignment of multiradiation isocenters for megavoltage photon beam
Authors: Zhang Yin , Ding Kai , Cowan Garth , Tryggestad Erik , Armour Elwood , Wang Ken Kang‐Hsin
Published: February 2017

The accurate measurement of the linear accelerator (linac) radiation isocenter is critical, especially for stereotactic treatment. Traditional quality assurance (QA) procedure focuses on the measurement of single radiation isocenter, usually of 6 megavoltage (MV) photon beams. Single radiation isocenter is also commonly assumed in treatment planning systems (TPS). Due to different flattening filters and bending magnet and steering parameters, the radiation isocenter of one energy mode can deviate from another if no special effort was devoted. We present the first experience of the multiradiation isocenters alignment on an Elekta linac, as well as its corresponding QA procedure and clinical impact. An 8 mm ball‐bearing (BB) phantom was placed at the 6 MV radiation isocenter using an Elekta isocenter search algorithm, based on portal images. The 3D radiation isocenter shifts of other photon energy modes relative to the 6 MV were determined. Beam profile scanning for different field sizes was used as an independent method to determine the 2D multiradiation isocenters alignment. To quantify the impact of radiation isocenter offset on targeting accuracy, the 10 MV radiation isocenter was manually offset from that for 6 MV by adjusting the bending magnet current. Because our table isocenter was mechanically aligned to the 6 MV radiation isocenter, the deviation of the table isocentric rotation from the "shifted" 10 MV radiation isocenter after bending magnet adjustment was assessed. Winston‐Lutz test was also performed to confirm the overall radiation isocenter positioning accuracy for all photon energies. The portal image method showed the radiation isocenter of the 10 MV flattening filter‐free mode deviated from others before beam parameter adjustment. After the adjustment, the deviation was greatly improved from 0.96 to 0.35 mm relative to the 6 MV radiation isocenter. The same finding was confirmed by the profile‐scanning method. The maximum deviation of the table isocentric rotation from the 10 MV radiation isocenter was observed to linearly increase with the offset between 6 and 10 MV radiation isocenter; 1 mm radiation isocenter offset can translate to almost 2 mm maximum deviation of the table isocentric rotation from the 10 MV radiation isocenter. The alignment of the multiradiation isocenters is particularly important for high‐precision radiotherapy. Our study provides the medical physics community with a quantitative measure of the multiradiation isocenters alignment. A routine QA method should be considered, to examine the radiation isocenters alignment during the linac acceptance.

PACS number: 87.55.Qr, 87.56.bd, 87.56.Fc
A method to improve dose gradient for robotic radiosurgery
Authors: Li Tianfang , Ozhasoglu Cihat , Burton Steven , Flickinger John , Heron Dwight E. , Huq M. Saiful
Published: February 2017

For targets with substantial volume, collimators of relatively large size are usually selected to minimize the treatment time in robotic radiosurgery. Their large penumbrae may adversely affect the dose gradient around the target. In this study, we implement and evaluate an inner‐shell planning method to increase the dose gradient and reduce dose to normal tissues. Ten patients previously treated with CyberKnife M6 system were randomly selected with the only criterion being that PTV be larger than . A new plan was generated for each patient in which the PTV was split into two regions: a 5 mm inner shell and a core, and a 7.5 mm Iris collimator was exclusively applied to the shell, with other appropriate collimators applied to the core depending on its size. The optimization objective, functions, and constraints were the same as in the corresponding clinical plan. The results were analyzed for V12 Gy, V9 Gy, V5 Gy, and gradient index (GI). Volume reduction was found for the inner‐shell method at all studied dose levels as compared to the clinical plans. The absolute dose‐volume reduction ranged from to with a mean of for 12 Gy, from to with a mean of for 9 Gy, and from to with a mean of for 5 Gy, respectively. The GI reduction ranged from 3.2% to 23.6%, with a mean of 12.6%. Paired t‐test for GI has a p‐value of 0.0014. The range for treatment time increase is from ‐3 min to 20 min, with a mean of 7.0 min. We conclude that irradiating the PTV periphery exclusively with the 7.5 mm Iris collimator, rather than applying mixed collimators to the whole PTV, can substantially improve the dose gradient, while maintaining good coverage, conformity, and reasonable treatment time.

PACS number: 87.55.de
Clinical implementation of photon beam flatness measurements to verify beam quality
Authors: Goodall Simon , Harding Nicholas , Simpson Jake , Alexander Louise , Morgan Steve
Published: February 2017

This work describes the replacement of Tissue Phantom Ratio (TPR) measurements with beam profile flatness measurements to determine photon beam quality during routine quality assurance (QA) measurements. To achieve this, a relationship was derived between the existing energy metric and beam flatness, to provide baseline values and clinically relevant tolerances. The beam quality was varied around two nominal beam energy values for four matched Elekta linear accelerators (linacs) by varying the bending magnet currents and reoptimizing the beam. For each adjusted beam quality the was measured using an ionization chamber and Solid Water phantom. Two metrics of beam flatness were evaluated using two identical commercial ionization chamber arrays. A linear relationship was found between and both metrics of flatness, for both nominal energies and on all linacs. Baseline diagonal flatness () values were measured to be 103.0% (ranging from 102.5% to 103.8%) for 6 MV and 102.7% (ranging from 102.6% to 102.8%) for 10 MV across all four linacs. Clinically acceptable tolerances of for 6 MV, and for 10 MV, were derived to equate to the current clinical tolerance of . Small variations in the baseline diagonal flatness values were observed between ionization chamber arrays; however, the rate of change of with diagonal flatness was found to remain within experimental uncertainty. Measurements of beam flatness were shown to display an increased sensitivity to variations in the beam quality when compared to TPR measurements. This effect is amplified for higher nominal energy photons. The derivation of clinical baselines and associated tolerances has allowed this method to be incorporated into routine QA, streamlining the process whilst also increasing versatility. In addition, the effect of beam adjustment can be observed in real time, allowing increased practicality during corrective and preventive maintenance interventions.

PACS number: 87.56.Fc
Comparison of volumetric‐modulated arc therapy and dynamic conformal arc treatment planning for cranial stereotactic radiosurgery
Authors: Molinier Jessica , Kerr Christine , Simeon Sebastien , Ailleres Norbert , Charissoux Marie , Azria David , Fenoglietto Pascal
Published: February 2017

The aim was to analyze arc therapy techniques according to the number and position of the brain lesions reported by comparing dynamic noncoplanar conformal arcs (DCA), two coplanar full arcs () with volumetric‐modulated arc therapy (VMAT), multiple noncoplanar partial arcs with VMAT (), and two full arcs with VMAT and 10° table rotation (). Patients with a single lesion (n = 10), multiple lesions (n = 10) or a single lesion close to organs at risk (n = 5) and previously treated with DCA were selected. For each patient, the DCA treatment was replanned with all VMAT techniques. All DCA plans were compared with VMAT plans and evaluated in regard to the different quality indices and dosimetric parameters. For single lesion, homogeneity index (HI) better results were found for the technique () compared with DCA procedure (). Concerning conformity index (CI), the technique gave higher and better values () compared with those obtained with the DCA technique (). DCA improved healthy brain protection ( vs. for ) and reduced monitor unit numbers ( MU vs. for ), even if global room occupation was higher. For multiple lesions, VMAT techniques provided better HI (0.16) than DCA (). The CI was improved with ( for vs. for DCA). The healthy brain was better protected with DCA (). Regarding the MU numbers: . For a single lesion close to OAR, achieved high degrees of homogeneity ( vs. for DCA) and conformity ( vs. for DCA) while sparing organs at risk ( vs. for DCA, and vs. for DCA). On the other hand, MU numbers were lower with DCA ( MU vs. MU for ) even if overall time was inferior with . For a single lesion, DCA provide better plan considering low doses to healthy brain even if quality indexes are better for the others techniques. For multiple lesions, seems to be the best compromise, due to the ability to deliver a good conformity and homogeneity plan while sparing healthy brain tissue. For a single lesion close to organs at risk, is the most appropriate technique.

PACS numbers: 87.55. dk, 87.56.bd
Radiation intensity () and visibility of anatomical structures in head CT examinations
Authors: Tipnis Sameer , Thampy Rajesh , Rumboldt Zoran , Spampinato Maria , Matheus Gisele , Huda Walter
Published: February 2017

The purpose of this study was to quantify how changing the amount of radiation used to perform routine head CT examinations () affects visibility of key anatomical structures. Eight routine noncontrast head CT exams were selected from six CT scanners, each of which had a different setting (60 to 75 mGy). All exams were normal and two slices were selected for evaluation, one at the level of basal ganglia and the other at the fourth ventricle. Three experienced neuroradiologists evaluated the visibility of selected structures, including the putamen, caudate nucleus, thalamus, internal capsule, grey/white differentiation, and brainstem. Images were scored on a five‐point scoring scheme (1, unacceptable, 3, satisfactory, and 5, excellent). Reader scores, averaged over the cases obtained from each scanner, were plotted as a function of the corresponding . Average scores for the fourth ventricle were and for the basal ganglia were . No image received a score of 1. Two readers showed no clear trend of an increasing score with increasing . One reader showed a slight trend of increasing score with increasing , but the increase in score from a 25% increase in was a fraction of the standard deviation associated average scores. Collectively, results indicated that there were no clear improvements in visualizing neuroanatomy when increased from 60 to 75 mGy in routine head CT examinations. Our study showed no apparent benefit of using more than 60 mGy when performing routine noncontrast head CT examinations.

PACS number(s): 87.57.C‐
Size‐based protocol optimization using automatic tube current modulation and automatic kV selection in computed tomography
Authors: MacDougall Robert D. , Kleinman Patricia L. , Callahan Michael J.
Published: February 2017

Size‐based diagnostic reference ranges (DRRs) for contrast‐enhanced pediatric abdominal computed tomography (CT) have been published in order to establish practical upper and lower limits of CTDI, DLP, and SSDE. Based on these DRRs, guidelines for establishing size‐based SSDE target levels from the SSDE of a standard adult by applying a linear correction factor have been published and provide a great reference for dose optimization initiatives. The necessary step of designing manufacturer‐specific CT protocols to achieve established SSDE targets is the responsibility of the Qualified Medical Physicist. The task is straightforward if fixed‐mA protocols are used, however, more difficult when automatic exposure control (AEC) and automatic kV selection are considered. In such cases, the physicist must deduce the operation of AEC algorithms from technical documentation or through testing, using a wide range of phantom sizes. Our study presents the results of such testing using anthropomorphic phantoms ranging in size from the newborn to the obese adult. The effect of each user‐controlled parameter was modeled for a single‐manufacturer AEC algorithm (Siemens CARE Dose4D) and automatic kV selection algorithm (Siemens CARE kV). Based on the results presented in this study, a process for designing mA‐modulated, pediatric abdominal CT protocols that achieve user‐defined SSDE and kV targets is described.

PACS numbers: 87.57.Q‐, 87.57.qp, 87.53.Bn
Quantification of interplay and gradient effects for lung stereotactic ablative radiotherapy (SABR) treatments
Authors: Tyler Madelaine K.
Published: February 2017

This study quantified the interplay and gradient effects on GTV dose coverage for 3D CRT, dMLC IMRT, and VMAT SABR treatments for target amplitudes of 5–30 mm using 3DVH v3.1 software incorporating 4D Respiratory MotionSim (4D RMS) module. For clinically relevant motion periods (5 s), the interplay effect was small, with deviations in the minimum dose covering the target volume (D99%) of less than for target amplitudes up to 30 mm. Increasing the period to 60 s resulted in interplay effects of up to on target D99% dose coverage. The gradient effect introduced by target motion resulted in deviations of up to in D99% target dose coverage. VMAT treatments showed the largest deviation in dose metrics, which was attributed to the long delivery times in comparison to dMLC IMRT. Retrospective patient analysis indicated minimal interplay and gradient effects for patients treated with dMLC IMRT at the NCCI.

PACS numbers: 87.55.km, 87.56.Fc
Approaches to interventional fluoroscopic dose curves
Authors: Wunderle Kevin A. , Rakowski Joseph T. , Dong Frank F.
Published: February 2017

Modern fluoroscopes used for image‐based guidance in interventional procedures are complex X‐ray machines, with advanced image acquisition and processing systems capable of automatically controlling numerous parameters based on defined protocol settings. This study evaluated and compared approaches to technique factor modulation and air kerma rates in response to simulated patient thickness variations for four state‐of‐the‐art and one previous‐generation interventional fluoroscopes. A polymethyl methacrylate (PMMA) phantom was used as a tissue surrogate for the purposes of determining fluoroscopic reference plane air kerma rates, kVp, mA, and variable copper filter thickness over a wide range of simulated tissue thicknesses. Data were acquired for each fluoroscopic and acquisition dose curve within each vendor's default abdomen or body imaging protocol. The data obtained indicated vendor‐ and model‐specific variations in the approach to technique factor modulation and reference plane air kerma rates across a range of tissue thicknesses. However, in the imaging protocol evaluated, all of the state‐of‐the‐art systems had relatively low air kerma rates in the fluoroscopic low‐dose imaging mode as compared to the previous‐generation unit. Each of the newest‐generation systems also employ Cu filtration within the selected protocol in the acquisition mode of imaging; this is a substantial benefit, reducing the skin entrance dose to the patient in the highest dose‐rate mode of fluoroscope operation. Some vendors have also enhanced the radiation output capabilities of their fluoroscopes which, under specific conditions, may be beneficial; however, these increased output capabilities also have the potential to lead to unnecessarily high dose rates. Understanding how fluoroscopic technique factors are modulated provides insight into the vendor‐specific image acquisition approach and may provide opportunities to optimize the imaging protocols for clinical practice.

PACS number: 87.59.C‐
Dosimetric impact of dental metallic crown on intensity‐modulated radiotherapy and volumetric‐modulated arc therapy for head and neck cancer
Authors: Kamomae Takeshi , Itoh Yoshiyuki , Okudaira Kuniyasu , Nakaya Takayoshi , Tomida Masashi , Miyake Yoshikazu , Oguchi Hiroshi , Shiinoki Takehiro , Kawamura Mariko , Yamamoto Noriyuki , Naganawa Shinji
Published: February 2017

Metal dental restoration materials cause dose enhancement upstream and dose disturbance downstream of the high‐density inhomogeneous regions in which these materials are used. In this study, we evaluated the impact of a dental metallic crown (DMC) on intensity‐modulated radiotherapy (IMRT) and volumetric‐modulated arc therapy (VMAT) for head and neck cancer. Additionally, the possibility of sparing the oral mucosa from dose enhancement using an individual intraoral mouthpiece was evaluated. An experimental oral phantom was designed to verify the dosimetric impact of a DMC. We evaluated the effect on single beam, parallel opposing beam, arc beam, IMRT, and VMAT treatment plans. To evaluate the utility of a 3‐mm‐thick intraoral mouthpiece, the doses across the mouthpiece were measured. For single beam irradiation, the measured doses at the entrance and exit planes of the DMC were 51% higher and 21% lower than the calculated dose by the treatment planning system, respectively. The maximum dose enhancements were 22% and 46% for parallel opposing beams and the 90° arc rotation beam, respectively. For IMRT and VMAT, the measured doses adjacent to the DMC were () and higher than the calculated doses, respectively. With regard to the performance of the intraoral mouthpiece for the IMRT and VMAT cases, the disagreement between measured and calculated doses at the outermost surface of the mouthpieces were , and 2.0%, respectively. Dose enhancements caused by DMC‐mediated radiation scattering occurred during IMRT and VMAT. Because it is difficult to accurately estimate the dose perturbations, careful consideration is necessary when planning head and neck cancer treatments in patients with DMCs. To spare the oral mucosa from dose enhancement, the use of an individual intraoral mouthpiece should be considered.

PACS numbers: 87.55.km, 87.55.N‐, 87.55.Qr
Commissioning of a 3D image‐based treatment planning system for high‐dose‐rate brachytherapy of cervical cancer
Authors: Kim Yongbok , Modrick Joseph M. , Pennington Edward C. , Kim Yusung
Published: February 2017

The objective of this work is to present commissioning procedures to clinically implement a three‐dimensional (3D), image‐based, treatment‐planning system (TPS) for high‐dose‐rate (HDR) brachytherapy (BT) for gynecological (GYN) cancer. The physical dimensions of the GYN applicators and their values in the virtual applicator library were varied by 0.4 mm of their nominal values. Reconstruction uncertainties of the titanium tandem and ovoids (T&O) were less than 0.4 mm on CT phantom studies and on average between 0.8‐1.0 mm on MRI when compared with X‐rays. In‐house software, HDRCalculator, was developed to check HDR plan parameters such as independently verifying active tandem or cylinder probe length and ovoid or cylinder size, source calibration and treatment date, and differences between average Point A dose and prescription dose. Dose‐volume histograms were validated using another independent TPS. Comprehensive procedures to commission volume optimization algorithms and process in 3D image‐based planning were presented. For the difference between line and volume optimizations, the average absolute differences as a percentage were 1.4% for total reference air KERMA (TRAK) and 1.1% for Point A dose. Volume optimization consistency tests between versions resulted in average absolute differences in 0.2% for TRAK and 0.9 s (0.2%) for total treatment time. The data revealed that the optimizer should run for at least 1 min in order to avoid more than 0.6% dwell time changes. For clinical GYN T&O cases, three different volume optimization techniques (graphical optimization, pure inverse planning, and hybrid inverse optimization) were investigated by comparing them against a conventional Point A technique. End‐to‐end testing was performed using a T&O phantom to ensure no errors or inconsistencies occurred from imaging through to planning and delivery. The proposed commissioning procedures provide a clinically safe implementation technique for 3D image‐based TPS for HDR BT for GYN cancer.

PACS number(s): 87.55.D‐
Simultaneous MV‐kV imaging for intrafractional motion management during volumetric‐modulated arc therapy delivery*
Authors: Hunt Margie A. , Sonnick Mark , Pham Hai , Regmi Rajesh , Xiong Jian‐ping , Morf Daniel , Mageras Gig S. , Zelefsky Michael , Zhang Pengpeng
Published: February 2017

The purpose of this study was to evaluate the accuracy and clinical feasibility of a motion monitoring method employing simultaneously acquired MV and kV images during volumetric‐modulated arc therapy (VMAT). Short‐arc digital tomosynthesis (SA‐DTS) is used to improve the quality of the MV images that are then combined with orthogonally acquired kV images to assess 3D motion. An anthropomorphic phantom with implanted gold seeds was used to assess accuracy of the method under static, typical prostatic, and respiratory motion scenarios. Automatic registration of kV images and single MV frames or MV SA‐DTS reconstructed with arc lengths from 2° to 7° with the appropriate reference fiducial template images was performed using special purpose‐built software. Clinical feasibility was evaluated by retrospectively analyzing images acquired over four or five sessions for each of three patients undergoing hypofractionated prostate radiotherapy. The standard deviation of the registration error in phantom using MV SA‐DTS was similar to single MV images for the static and prostate motion scenarios (). Under respiratory motion conditions, the standard deviation of the registration error increased to 0.7 mm and 1.7 mm for single MV and MV SA‐DTS, respectively. Registration failures were observed with the respiratory scenario only and were due to motion‐induced fiducial blurring. For the three patients studied, the mean and standard deviation of the difference between automatic registration using 4° MV SA‐DTS and manual registration using single MV images results was . The MV SA‐DTS results in patients were, on average, superior to single‐frame MV by nearly 1 mm — significantly more than what was observed in phantom. The best MV SA‐DTS results were observed with arc lengths of 3° to 4°. Registration failures in patients using MV SA‐DTS were primarily due to blockage of the gold seeds by the MLC. The failure rate varied from 2% to 16%. Combined MV SA‐DTS and kV imaging is feasible for intratreatment motion monitoring during VMAT of anatomic sites where limited motion is expected, and improves registration accuracy compared to single MV/kV frames. To create a clinically robust technique, further improvements to ensure visualization of fiducials at the desired control points without degradation of the treatment plan are needed.

PACS number(s): 87.55.km, 87.55.N‐
Methods to model and predict the ViewRay treatment deliveries to aid patient scheduling and treatment planning
Authors: Liu Shi , Wu Yu , Wooten H. Omar , Green Olga , Archer Brent , Li Harold , Yang Deshan
Published: February 2017

A software tool is developed, given a new treatment plan, to predict treatment delivery time for radiation therapy (RT) treatments of patients on ViewRay magnetic resonance image‐guided radiation therapy (MR‐IGRT) delivery system. This tool is necessary for managing patient treatment scheduling in our clinic. The predicted treatment delivery time and the assessment of plan complexities could also be useful to aid treatment planning. A patient's total treatment delivery time, not including time required for localization, is modeled as the sum of four components: 1) the treatment initialization time; 2) the total beam‐on time; 3) the gantry rotation time; and 4) the multileaf collimator (MLC) motion time. Each of the four components is predicted separately. The total beam‐on time can be calculated using both the planned beam‐on time and the decay‐corrected dose rate. To predict the remain‐ing components, we retrospectively analyzed the patient treatment delivery record files. The initialization time is demonstrated to be random since it depends on the final gantry angle of the previous treatment. Based on modeling the relationships between the gantry rotation angles and the corresponding rotation time, linear regression is applied to predict the gantry rotation time. The MLC motion time is calculated using the leaves delay modeling method and the leaf motion speed. A quantitative analysis was performed to understand the correlation between the total treatment time and the plan complexity. The proposed algorithm is able to predict the ViewRay treatment delivery time with the average prediction error 0.22 min or 1.82%, and the maximal prediction error 0.89 min or 7.88%. The analysis has shown the correlation between the plan modulation (PM) factor and the total treatment delivery time, as well as the treatment delivery duty cycle. A possibility has been identified to significantly reduce MLC motion time by optimizing the positions of closed MLC pairs. The accuracy of the proposed prediction algorithm is sufficient to support patient treatment appointment scheduling. This developed software tool is currently applied in use on a daily basis in our clinic, and could also be used as an important indicator for treatment plan complexity.

PACS number(s): 87.55.N
Assessment of national dosimetry quality audits results for teletherapy machines from 1989 to 2015
Authors: Muhammad Wazir , Ullah Asad , Mahmood Khalid , Matiullah
Published: February 2017

The purpose of this study was to ensure accuracy in radiation dose delivery, external dosimetry quality audit has an equal importance with routine dosimetry performed at clinics. To do so, dosimetry quality audit was organized by the Secondary Standard Dosimetry Laboratory (SSDL) of Pakistan Institute of Nuclear Science and Technology (PINSTECH) at the national level to investigate and minimize uncertainties involved in the measurement of absorbed dose, and to improve the accuracy of dose measurement at different radiotherapy hospitals. A total of 181 dosimetry quality audits (i.e., 102 of Co‐60 and 79 of linear accelerators) for teletherapy units installed at 22 different sites were performed from 1989 to 2015. The percent deviation between users’ calculated/stated dose and evaluated dose (in the result of on‐site dosimetry visits) were calculated and the results were analyzed with respect to the limits of (ICRU “optimal model”) (IAEA on‐site dosimetry visits limit) and (ICRU minimal or “lowest acceptable” model). The results showed that out of 181 total on‐site dosimetry visits, 20.44%, 16.02%, and 4.42% were out of acceptable limits of , and , respectively. The importance of a proper ongoing quality assurance program, recommendations of the followed protocols, and properly calibrated thermometers, pressure gauges, and humidity meters at radiotherapy hospitals are essential in maintaining consistency and uniformity of absorbed dose measurements for precision in dose delivery.

PACS number(s): 87.50.cm, 87.50.sj, 87.50.up, 87.50.wj, 87.50.yk, 87.55.km, 87.55.Qr
The MapCHECK Measurement Uncertainty function and its effect on planar dose pass rates
Authors: Bailey Daniel W. , Spaans Jason D. , Kumaraswamy Lalith K. , Podgorsak Matthew B.
Published: February 2017

Our study aimed to quantify the effect of the Measurement Uncertainty function on planar dosimetry pass rates, as measured and analyzed with the Sun Nuclear Corporation MapCHECK 2 array and its associated software. This optional function is toggled in the program preferences of the software (though turned on by default upon installation), and automatically increases the dose difference tolerance defined by the user for each planar dose comparison. Dose planes from 109 static‐gantry IMRT fields and 40 VMAT arcs, of varying modulation complexity, were measured at 5 cm water‐equivalent depth in the MapCHECK 2 diode array, and respective calculated dose planes were exported from a commercial treatment planning system. Planar dose comparison pass rates were calculated within the Sun Nuclear Corporation analytic software using a number of calculation parameters, including Measurement Uncertainty on and off. By varying the percent difference (%Diff) criterion for similar analyses performed with Measurement Uncertainty turned off, an effective %Diff criterion was defined for each field/arc corresponding to the pass rate achieved with Measurement Uncertainty turned on. On average, the Measurement Uncertainty function increases the user‐defined %Diff criterion by 0.8%‐1.1% for 3%/3 mm analysis, depending on plan type and calculation technique (corresponding to an average change in pass rate of 1.0%‐3.5%, and a maximum change of 8.7%). At the 2%/2 mm level, the Measurement Uncertainty function increases the user‐defined %Diff criterion by 0.7%‐1.2% on average, again depending on plan type and calculation technique (corresponding to an average change in pass rate of 3.5%‐8.1%, and a maximum change of 14.2%). The largest increases in pass rate due to the Measurement Uncertainty function are generally seen with poorly matched planar dose comparisons, while the function has a notably smaller effect as pass rates approach 100%. The Measurement Uncertainty function, then, may substantially increase the pass rates for planar dose comparisons. Meanwhile, the types of uncertainties incorporated into the function (and their associated quantitative estimates, as described in the software user's manual) may not be an accurate estimation of actual measurement uncertainty, depending on the user's measurement conditions. Pass rates listed in published reports, comparisons between institutions or simply separate workstations, or comparisons with the calculation methods of other vendors, should clearly indicate whether or not the Measurement Uncertainty function is used, since it has the potential to substantially inflate pass rates for typical IMRT and VMAT dose planes.

PACS number(s): 87.55.Qr, 87.56.Fc
A comparison of organs at risk doses in GYN intracavitary brachytherapy for different tandem lengths and bladder volumes
Authors: Siavashpour Zahra , Aghamiri Mahmoud Reza , Jaberi Ramin , ZareAkha Naser , Manshadi Hamid Reza Dehghan , Kirisits Christian , Sedaghat Mahbod
Published: February 2017

The purpose of this study was to investigate the concurrent effects of tandem length and bladder volume on dose to pelvic organs at risk (OARs) in HDR intracavitary brachytherapy treatment of cervical cancer. Twenty patients with locally advanced cervical cancer were selected for brachytherapy using Rotterdam applicators. The patients were CT scanned twice with empty and full bladder. Two treatment plans were prepared on each of the image sets. Patients were categorized into two groups; those treated with a tandem length of 4 cm or smaller and those with tandem length larger than 4 cm (). Only one tandem tip angle of 30° was studied. Dose‐volume histograms (DVHs) of OARs were calculated and compared. Bladder dose was significantly affected by both bladder volume and tandem physical length for . This was reflected on the values obtained for , , and for both empty and full bladder cases. When , no correlation could be established between variations in bladder dose and bladder volume. Rectum dose was generally lower when the bladder was empty and . Dose to sigmoid was increased when ; this increase was larger when the bladder was full. Our results suggest that, for tandems longer than 4 cm, keeping the bladder empty may reduce the dose to rectum and sigmoid. This is contrary to cases where a shorter than 4 cm tandem is used in which a full bladder (about 50–120 cm3) tends to result in a lower dose to rectum and sigmoid. Attention should be given to doses to sigmoid with long tandem lengths, as a larger tandem generally results in a larger dose to sigmoid.

PACS number(s): 87.53.Jw
Output factor comparison of Monte Carlo and measurement for Varian TrueBeam 6 MV and 10 MV flattening filter‐free stereotactic radiosurgery system
Authors: Cheng Jason Y. , Ning Holly , Arora Barbara C. , Zhuge Ying , Miller Robert W.
Published: February 2017

The dose measurements of the small field sizes, such as conical collimators used in stereotactic radiosurgery (SRS), are a significant challenge due to many factors including source occlusion, detector size limitation, and lack of lateral electronic equilibrium. One useful tool in dealing with the small field effect is Monte Carlo (MC) simulation. In this study, we report a comparison of Monte Carlo simulations and measurements of output factors for the Varian SRS system with conical collimators for energies of 6 MV flattening filter‐free (6 MV) and 10 MV flattening filter‐free (10 MV) on the TrueBeam accelerator. Monte Carlo simulations of Varian's SRS system for 6 MV and 10 MV photon energies with cones sizes of 17.5 mm, 15.0 mm, 12.5 mm, 10.0 mm, 7.5 mm, 5.0 mm, and 4.0 mm were performed using EGSnrc (release V4 2.4.0) codes. Varian's version‐2 phase‐space files for 6 MV and 10 MV of TrueBeam accelerator were utilized in the Monte Carlo simulations. Two small diode detectors Edge (Sun Nuclear) and Small Field Detector (SFD) (IBA Dosimetry) were applied to measure the output factors. Significant errors may result if detector correction factors are not applied to small field dosimetric measurements. Although it lacked the machine‐specific correction factors for diode detectors in this study, correction factors were applied utilizing published studies conducted under similar conditions. For cone diameters greater than or equal to 12.5 mm, the differences between output factors for the Edge detector, SFD detector, and MC simulations are within 3.0% for both energies. For cone diameters below 12.5 mm, output factors differences exhibit greater variations.

PACS number(s): 87.55.k, 87.55.Qr