bluuebunny/crossref_metadata_2025 huggingface dataset:
NEPHROPROTECTIVE EFFECT OF A COMBINATION OF THE PEPTIDE MIMICKING THE a-SPATIAL STRUCTURE OF THE p ERYTHROPOIETIN CHAIN AND INFLIXIMAB IN RENAL ISCHEMIA-REPERFUSION INJURY
Authors: Netrebenko A. S , Elagin V. V. , Kostina D. A , Gureev V. V , Pokrovsky M. V , Yakushev V. I , Saprykina E. G , Zatolokina M. A , Orlova T. V
Published: January 2023

Resume. The search for new drugs with cytoprotective and anti-ischemic activity is an urgent task of modern pharmacology. These properties are necessary for the complex protection of renal parenchyma during organ preservation operations (renal resection), most often carried out in conditions of thermal ischemia. Only the combined use of modern highly effective drugs and the skill of an operating surgeon can prevent the development of acute renal injury (AKI) due to pinching of renal vessels. The aim of this study was to investigate the nephroprotective effects of a combination of a peptide mimicking the a-helix B of erythropoietin (pHBSP) and infliximab in ischemic reperfusion damage to the kidneys. Methods. The experiment was conducted on 50 white laboratory male Wistar rats weighing 280-320 g. Animals were injected with a peptide mimicking the a-helix B of erythropoietin (pHBSP) and infliximab. Under anesthesia, atraumatic vascular clamps were applied to the left renal pedicle for 40 minutes, nephrectomy on the right. Functional samples and laboratory tests were performed 5 minutes and 72 hours after reperfusion. Results. As a result of the study, it was shown that using a combination of the peptide simulating a-helix B erythropoietin (pHBSP) and infliximab in ischemic-reperfusion kidney injury showed significantly more pronounced nephroprotective effects than using the peptide mimicking a-helix B erythropoietin or infliximab in the mono mode. Conclusion.The results of the study show the promise of combined use of peptide simulating a-helix B erythropoietin (pHBSP) and infliximab in order to correct ischemic-reperfusion kidney injuries.
PHARMACOLOGICAL ANALYSIS OF THE MECHANISMS OF ACTION OF A OUINOXALINE DERIVATIVE WITH ANXIOLYTIC PROPERTIES
Authors: Skripka M. O , Maltsev D. V , Spasov A. A , Perfiliev M. A
Published: January 2023

The interactions of compound ZDM-81 with some CNS neurotransmitter systems were studied using in vivo methods to evaluate the interaction of the compound with dopaminergic (catalepsy, induced with haloperidol), adrenergic (clonidine hypothermia), GABAergic (test of interaction with flumazenil) and serotonergic (5-hydroxytryptophan hyperkinesis) systems. It was shown that the ZDM-81 compound is able to prolong and potentiate the effects of 5-hydroxytryptophan, reduces catalepsy caused by haloperidol, does not affect the hypothermic effect of clonidine, and the effect of the ZDM-81 compound is blocked by flumazenil. Thus, for the studied substance, a serotonergic, GABAergic, and weak dopaminergic pathway for the realization of the action was shown, which requires further research.
COMPARATIVE ANALYSIS OF THE COMBINED RISK OF PROGRESSION OF CHRONIC KIDNEY DISEASE AND THE DEVELOPMENT OF CARDIOVASCULAR COMPLICATIONS IN PATIENTS WITH ARTERIAL HYPERTENSION AND PATIENTS WITH ARTERIAL HYPERTENSION IN COMBINATION WITH TYPE 2 DIABETES MELLITUS USING SOFTWARE TOOLS
Authors: Derevyanchenko M. V. , Fedotov V. V. , Shaposhnikova M. Yu. , Kolodin S. V.
Published: January 2023

The article presents a comparative analysis of the combined risk of progression of chronic kidney disease (CKD) and the development of cardiovascular complications (CVD) in patients with arterial hypertension (AH) and AH patients in combination with type 2 diabetes meUitus (DM) using software tools. It is proposed to use the "HeartCare" Internet resource developed by the authors, which presents the main methods for determining cardiovascular and combined risk in various groups of patients. It was noted that among persons with AH and DM type 2, patients with high and very high combined risk were statistically significantly more likely to be identified in comparison with patients with "isolated" hypertension (55,2 vs 17,1 % in the main and control groups, respectively). The "HeartCare" resource allows you to evaluate personal risks in dynamics.
A METHOD FOR MORPHOMETRIC ASSESSMENT OF PATHOLOGICAL CONDITIONS OF THE RETINA AND CHOROID BASED ON SCANS OF OPTICAL COHERENCE TOMOGRAPHY OF THE EYE
Authors: Bondarenko Yu. F , Epikhin A. N , Epikhina Yu. N , Filippenko V. A , Dolgov V. V
Published: January 2023

Optical coherence tomography (OCT) is a modern non-contact method of diagnostic examination which makes it possible to visualize a section of the retina as close as possible to its post-mortem histological section, and enables to distinguish individual layers of the human retina in a cross-section. The software pre-installed in such devices contains many different tools, but this is still not enough for a faster, more complete and accurate analysis of the obtained scans in order to make the correct diagnosis and choose the best treatment. There are more and more new and improved technologies for image processing in the world, which sets new tasks to develop additional software that can complement and expand the functionality of diagnostic equipment. This paper proposes a method of morphometric assessment of pathological conditions of the retina and chorioidea based on optical coherence tomography scans. This method is based on the algorithm for automated segmentation of the borders of the macular macular zone pathological focus, the algorithm for calculation of the area and volume of the pathological focus which together with other algorithms for analysis of the morphometric parameters of the human eye can be used for differential diagnostics of the pathological changes in the macular zone, for more precise diagnosis of the age-related macular degeneration (AMD) stage to prescribe a certain type and volume of treatment for stabilization and improvement of the central pontine visual functions.
IMPACT OF DEMOGRAPHIC VARIABLES ON THE RISK OF PANCREATOGENIC ENCEPHALOPATHY IN PATIENTS WITH NUTRITIONAL PANCREATONECROSIS
Authors: Beburishvili A. G , Mikhin V. S , Burchuladze N. Sh , Popov A. S , Turovets M. I , Mikhin I. V , Kitaeva A. V.
Published: January 2023

Resume. Aim. Study of the dependence of the degree of risk of developing pancreatogenic encephalopathy (PEP) on demographic variables in patients with nutritional pancreatic necrosis. Materials and methods. A single-center prospective cohort non-randomized study was conducted on the basis of the Faculty Surgery Clinic of the Volgograd State Medical University in the period from 2010 to 2020. To determine the significance of the influence of a patient-dependent factor on the risk of developing PEP, ROC analysis was used. Logistic regression analysis was used to determine the degree of risk of developing PEP against the background of a combination of several covariates. Results. The study included 429 patients with pancreatic necrosis of alimentary origin. A comparative analysis of the incidence of PEP was carried out depending on gender and age, the trigger of the disease (alcohol-associated versus non-alcoholic pancreatic necrosis) and comorbid background. It has been proven that significant factors that increase the risk of developing PEP are age over 60 years (p = 0,04), alcohol-associated pancreatic necrosis (p < 0,001) and cardiovascular pathology - ischemic heart disease (p < 0,001). A statistically significant regression model of the effect of cardiovascular pathology on the incidence of PEP has been developed, which makes it possible to calculate the risk of this complication in a particular patient. Conclusions. Significant demographic variables that increase the risk of PEP include age over 60 years, alcoholic pancreatitis, and the presence of coronary artery disease in a patient. The developed logistic model makes it possible to calculate the personalized risk of PEP during hospitalization of a patient with nutritional pancreatic necrosis.
MEDICAL ERRORS IN PRACTICE DENTIST-SURGEON (REVIEW ARTICLE)
Authors: Shkarin V. V , Sedova N. N , Yarygina E. N , Dronov S. V.
Published: January 2023

Medical errors in dentistry are a complex problem. There is no unambiguous and comprehensive definition of this concept. The article examines the existing classifications of medical errors, discusses their advantages and disadvantages. Possible alternative classifications of medical errors for objective and subjective reasons, for medical and non-medical factors influencing diagnosis and treatment, according to the severity of the harm done to the patient are considered. Medicine is developing, so the term "medical error" requires not just a modern view, but also official recognition as a problem. It is necessary to supplement and clarify it, for ease of use in official medical documents.
MOLECULAR AND MORPHOLOGICAL MARKERS OF NEURONAL DEATHIN ACUTE CEREBRAL CIRCULATIONDISORDERS
Authors:   I.M. Sechenov First Moscow State Medical University, Kudryavtseva V.A. , Kuzmin E.A. ,   I.M. Sechenov First Moscow State Medical University, Moiseeva A.V. ,   I.M. Sechenov First Moscow State Medical University, Obelchakova M.S. ,   I.M. Sechenov First Moscow State Medical University, Sinitsyna P.A. ,   I.M. Sechenov First Moscow State Medical University, Piavchenko G.A. ,   I.M. Sechenov First Moscow State Medical University, Kartashkina N.L. ,   I.M. Sechenov First Moscow State Medical University, Alekseev A.G. ,   I.S. Turgenev Orel State University, Golubev A.M. ,   V.A.Negovsky Scientific Research Institute of General Reanimatology, Zatolokina M.A. ,   I.S. Turgenev Orel State University,   Kursk State Medical University, Kuznetsov S.L. ,   I.M. Sechenov First Moscow State Medical University
Published: January 2023

Acute cerebral circulatory disorders are characterised by various changes in brain cells, often leading to mass death. This review presents a list of markers associated with different types of cell death occurring in acute cerebral circulation disorders and identifies the importance of these markers in the diagnosis of haemorrhagic and ischaemic stroke.Acute cerebral circulation disorder is one of the most debated issues in modern resuscitation and medicine, asit is asevere condition leading to stroke and subsequent patient death, if not treated promptly. However, rapid treatment and diagnosis of stroke is difficult due to the lack of study of morphological signs and biomarkers to reliably determine the nature of the injury. Anin-depth analysis and systematization of the available information on this topic is needed.Purpose of the review:to reveal the correspondence between the molecular mechanisms of cell death in acute disorders ofcerebral circulation and their morphological manifestations.Material and Methods.A total of 50 most relevant sources of information were selected. The sources were selected from the databases of medical and biological publications PubMed, Scopus, Web of Science, RSCI, and fundamental works of scientificliterature on the considered topic were involved.Results.The main mechanisms of cell death in stroke were identified and analyzed, the morphological and histological features ofthe observed processes and their structural manifestations were reviewed. Besides, the most frequently detected molecular markers specific for each type of cell death were listed.Conclusion.The study of molecular pathways andcellular reorganization processes characteristic of different types of cell death as well as their corresponding biological markers is of important diagnostic value in the detection of cerebral circulatory disorders. Determination of morphological and molecular markers typical for this condition will allow a prompt diagnosis ofstroke and minimization of its negative consequences.
RELATIONSHIP OF SOMATIC SYSTEMIC DISTURBANCES, THE TRIGGER OF PANCREATIC NECROSISAND PANCREATOGENIC ENCEPHALOPATHY
Authors:   Volgograd State Medical University, Beburishvili A.G. , Mikhin V.S. ,   Volgograd State Medical University, Burchuladze N.Sh. ,   Volgograd State Medical University, Popov A.S. ,   Volgograd State Medical University, Turovets M.I. ,   Volgograd State Medical University, Mikhin I.V. ,   Volgograd State Medical University, Kitaeva A.V. ,   Volgograd State Medical University
Published: January 2023

Aim. To study the influence of systemic disorders on the risk of developing pancreatogenic encephalopathy.Materials and methods.In the period from 2010 to 2020, a prospective non-randomized cohort study was conducted at theclinical base of Department of Faculty Surgery of Volgograd State Medical University. ROC analysis was used to determine the impact of systemic disorders on the risk of developing pancreatogenic encephalopathy (PEP). The influence of the pancreatic necrosis trigger on the risk of multiple organ failure syndrome (MOF) was determined using logistic regression analysis. Results.The study included 429 patients with acute destructive pancreatitis. It was revealed that the debut of systemic disorders occurred on average on the first day of hospitalization. The most common were intestinal and cardiovascular insufficiency –336 (78,3 %) and 242 (56,4 %) cases, respectively. In patients with alcohol-associated pancreatic necrosis (AAPN), intestinal failure was significantly more common [144 (84,7 %) versus 192 (74,1 %),OR = 1,93, CI 1,164–3,210, p= 0,012] and multiple systemic disorders [159 (93,5 %) versus 224 (86,5 %), OR = 1,18, CI 0,659–2,122, p= 0,025] than in patients with non-alcoholic pancreatic necrosis (NAPN).The conducted logistic regression analysis proved an increased risk of PEP in the presence of any organ dysfunction. However, no such relationship was found for acute renal failure. The risk of developing MODS in patients with AAPN increases by 37,5 % compared with patients with non-alcoholic pancreatic necrosis, while the specificity and sensitivity reach 75,3 % and70,0 %, respectively.Conclusions.In patients with alcoholic genesis of pancreatic necrosis, the risk of intestinal failure, as well as multiple systemic disorders, significantly increases. A significant increase in the likelihood of organ and multiorgan disorders in patients with pancreatogenic encephalopathy was revealed.
INFLUENCE OF N-(4-ACETOXYBENZOYL)POTASSIUM GLYCINATE ON SENSOR-MOTOR AND COGNITIVE DISORDERSIN RATS WITH CHRONICCEREBROVASCULAR INSUFFICIENCY
Authors:   Volgograd State Medical University, Verkholyak Dmitry V. , Bakulin Dmitry A. ,   Volgograd State Medical University, Tyurenkov Ivan N. ,   Volgograd State Medical University
Published: January 2023

The effect of a new conjugate of hydroxybenzoic acid with glycine on sensory-motor and cognitive impairments in experimental animals with chronic cerebrovascular insufficiency (CCI) was studied. CCI was modeled in rats by stenosis of thelumen of the carotid arteries in 60 %. 40 days after the operation, experimental groups were formed and the test compound was administered for 14 days. Citicoline was used as a reference drug, and saline was administered as placebo. After treatment with the Rotarod, Adhesion Test, Novel Object Recognition (NOR), and Morris Water Maze tests, the severity of sensory-motor and cognitive impairments was assessed. It was noted that in animals with CCI with placebo treatment, the pathology was accompanied by a pronounced impairment of coordination and sensory-motor function of the forelimbs, as wellas cognitive impairments (impaired short-term and long-term memory in the NOR and the Morris maze tests). The course introduction of anew conjugate of hydroxybenzoic acid with glycine contributed to a significant improvement in sensory-motor and cognitive functions in animals with CCI. The noted neuroprotective effect was comparable to that of the reference drug citicoline.
MINIMALLY INVASIVE TREATMENT OF PARAVERTEBRALABSCESSES DUE TO NONSPECIFICSPONDYLODISCITES (CLINICAL OBSERVATIONS)
Authors:   Volgograd State Medical University, Parovatkin M.I. , Aleksandrov V.V. ,   Volgograd State Medical University, Ponomarev K.E. ,   Volgograd State Medical University, Maskin S.S. ,   Volgograd State Medical University
Published: January 2023

Nonspecific purulent-inflammatory lesions of the spine are rare anddifficult to diagnose diseases. At the same time, there is an increase in the frequency of their occurrence and unsatisfactory treatment results remain.Aim of the study.By demonstrating these clinical cases, to emphasize the complexity of timely diagnosis of nonspecific spondylodiscites and their purulent-inflammatory complications, to show the possibilities of mini-invasive treatment options for the pathology in questionMaterial and methods.The description of these clinical cases was carried out in accordance with the recommendations and explanations of the CARE (CAse REport) and SCARE (Surgical CAse REport) groups. The article presents patients with nonspecific spondylodiscites with purulent-inflammatory complications who were treated at the State Clinical Hospital No. 25 of Volgograd. The study was carried out in accordance with the ethical norms of the Helsinki Declaration and the «Rules of Clinical Practicein the Russian Federation» approved by the Order of the Ministry of Health of the Russian Federation No.266 dated 06.19.2003. Patients gave their free informed consent to the publication of clinical cases in the open press.Results.Using the example of two clinical cases, the complexity of diagnosis and differential diagnosis of nonspecific spondylodiscites with purulent-inflammatory complications is shown, the possibility of percutaneous drainage of abscesses as an independent treatment option is substantiated.Conclusion.With a long-term pain syndrome in the back, not relieved bynonsteroidal anti-inflammatory drugs, and the presence of risk factors, an instrumental examination of the spine was performed to exclude this pathology. Sanitation anddrainage of a abscess can be an independent operation.
ANALYSIS OF THE EFFICACY AND SAFETY OF GENETICALLY ENGINEERED BIOLOGICAL THERAPYFOR MODERATELY SEVERE AND SEVERE FORMS OF PSORIASIS
Authors:   Volgograd State Medical University, Petrov V.I. , Shatalova O.V. ,   Volgograd State Medical University, Popov V.V. ,   Volgograd State Medical University, Shchava S.N. ,   Volgograd State Medical University
Published: January 2023

The article presents the data of the analysis of modern data on the efficacy and safety of genetically engineered biological drugs registered in the Russian Federation for the treatment of moderately severe and severe forms of psoriasis. Thereview of modern domestic and foreign literature showed a higher efficacy and safety of biological preparations compared with basic anti-inflammatory therapy and the expediency of prescribing TNF-αinhibitors, IL-12/23, IL-17, IL-23 inhibitors in various forms of psoriasis, given the degree severity and comorbid conditions. This review will help practitioners to determine the most optimal treatment regimen for moderately severe and severe forms of psoriasis.
MODERN CONCEPTS OF THE PATHOGENESIS OF TYPE 2 DIABETES MELLITUS
Authors:   Volgograd State Medical University, Kurkin D.V. , Morkovin E.I. ,   Volgograd State Medical University, Bakulin D.A. ,   Volgograd State Medical University, Gorbunova Yu.V. ,   Volgograd State Medical University, Strygin A.V. ,   Volgograd State Medical University, Robertus A.I. ,   A.I. Yevdokimov Moscow State University of Medicine and Dentistry,,   Pirogov Russian National Research Medical University, Makarenko I.E. ,   A.I. Yevdokimov Moscow State University of Medicine and Dentistry,,   Pharm-Holding, St. Petersburg, Saparova V.B. ,   A.I. Yevdokimov Moscow State University of Medicine and Dentistry,,   Pharm-Holding, St. Petersburg, Drai R.V. ,   Pharm-Holding, St. Petersburg, Petrov V.I. ,   Volgograd State Medical University
Published: January 2023

In Russia, type 2 diabetes affects more than 5 % of the population. Type 2 diabetes accounts for up to 95 % of all cases of diabetes mellitus, but its pathogenetic mechanisms have not yet been fully established.Aim. To summarize and analyze the literature data on the pathogenetic links of type 2 diabetes mellitus. Materials and methods. When searching for material for writing a review article, abstract databases PubMed, Google Scholar, e-Library, etc. were used. The search was carried out by publications for the period 1960–2022. The following words and phrases were chosen as parameters for literature selection: pathogenesis of type 2 diabetes mellitus; insulin resistance;endothelial dysfunction; β-cells in type 2 diabetes; inflammation and diabetes, glucose utilization.Results. The article presents the concept of normal glucose metabolism, the role of the loss of functional mass of β-cells, aspects of the synthesis and metabolismof glucose by the liver, the role of muscle tissue in the consumption of glucose, as well as the role of the kidneys in the development of a vicious circle of diabetic hyperglycemia. The role of vascular andmyocardial resistance to insulin, adipose inflammation, the "ominous octet" is considered. The place of insulin resistance in the development of obesity was determined, the issues of incretin effects and liver diseases associated with diabetes were raised.Conclusion. The generalized informationwill expand and deepen knowledge about the pathogenesis of type 2 diabetes mellitus, which, in turn, will serve as a potential basis for new approaches in the treatment of one of the most common diseases of the 21st century.
DEVELOPING GUIDELINES FOR UPGRADING GENERAL EDUCATION COURSES ON APPLYING THE SUFFICIENCY ECONOMY PHILOSOPHY IN REAL LIFE
Authors:   Faculty of Education, Department of Curriculum and Instruction, Muban Chombueng Rajabut University, Ratchaburi, Thailand, Thumchuea Noppadol , Dhoppupa Krittagan Charlie ,   Faculty of Education, Department of Curriculum and Instruction, Muban Chombueng Rajabut University, Ratchaburi, Thailand, Ngoenbat Wijitra ,   Faculty of Education, Department of Early Childhood Education, Muban Chombueng Rajabut University, Ratchaburi, Thailand, Phanthong Chaowalit ,   Faculty of Education, Department of Curriculum and Instruction, Muban Chombueng Rajabut University, Ratchaburi, Thailand, Nilacupt Kriangwut ,   Faculty of Education, Department of Curriculum and Instruction, Muban Chombueng Rajabut University, Ratchaburi, Thailand
Published: January 2023

The objectives of this research were 1) To study the basic information for knowledge development and enhancement of Understanding of applying Sufficiency Economy Philosophy in real life among students of Muban Chom Bueng Rajabhat University. 2) To develop guidelines for upgrading general education courses on applying the Sufficiency Economy Philosophy in real life. The results of the research were as follows: 1) The results of the study found that students develop and enhance their knowledge and understanding of how to apply Sufficiency Economy Philosophy in real life without advice or instruction in moral behavior and being thrifty and self-aware. and applying the Sufficiency Economy Philosophy in real life by following orders or orders in self-reliance behavior Knowledge and use of intelligence Unity and public consciousness, reasonableness, and conservation of the environment and natural resources. 2) Developing guidelines for upgrading general education courses. The topic of applying the Sufficiency Economy Philosophy in real life is divided into 3 steps: the course design process; the process of designing learning activities and the design process for measuring and evaluating learning outcomes. This research will be a guideline to raise the level of general education subjects. and as a guideline for further developing skills in the 21st century for undergraduate students.
Análise multitemporal da cobertura vegetal na Bacia Hidrográfica do Córrego Ceroula, Mato Grosso do Sul
Authors: Oliveira Ademir Kleber Morbeck de , Pirajá Rennan Vilhema
Published: January 2023

As bacias hidrográficas compreendem uma porção da superfície terrestre onde as águas superficiais convergem para um exutório, podendo ser encontradas em várias escalas e usadas como unidades de planejamento. Este trabalho objetiva avaliar as mudanças ocorridas na paisagem da bacia hidrográfica do córrego Ceroula, Estado de Mato Grosso do Sul, por meio da análise da cobertura vegetal e do uso da superfície da bacia em um recorte temporal de vinte e nove anos. Foram utilizadas imagens dos satélites Landsat 5 TM, de 03/08/1987 e 04/08/2005, e Landsat 8 OLI, de 02/08/2016, para obtenção do Índice de Vegetação por Diferença Normalizada (NDVI, em inglês); posteriormente, foi realizada a quantificação das classes representativas da superfície. Os resultados obtidos indicam que mais da metade da cobertura vegetal nativa da bacia foi substituída por atividades antrópicas e que a fitomassa florestal remanescente está relacionada às matas de galeria, enquanto as áreas desmatadas encontram-se nos interflúvios e no entorno de nascentes. O processo de desmatamento na região pode ameaçar a bacia como manancial de abastecimento da cidade de Campo Grande, já que, no interior desta, está localizada a Área de Preservação Ambiental do Ceroula, criada visando preservar os recursos hídricos para abastecimento urbano.
Efeitos da segmentação regional nos salários dos trabalhadores do Nordeste e Sudeste do Brasil
Authors: Souza Solange de Cassia Inforzato de , Almeida Caroline , Gomes Magno Rogério
Published: January 2023

O objetivo deste estudo é analisar os efeitos das macrorregiões brasileiras, nordeste e sudeste, sobre os rendimentos dos trabalhadores, a partir dos microdados da Pesquisa Nacional por Amostra de Domicílios (PNAD) de 2005 e 2015. Os resultados mostram que, no Sudeste, os trabalhadores são mais escolarizados, brancos e mulheres, e as diferenças mais marcantes referem-se à cor da pele e ao nível de formalização. Os retornos salariais advindos da escolaridade, do sexo feminino, da cor da pele branca e de moradores da região urbana são menores para os trabalhadores do Nordeste. A abordagem contrafactual confirma a diferença salarial desfavorável ao Nordeste, decorrente dos atributos individuais e dos postos de trabalho, e dos atributos regionais, da dinâmica própria da localidade. Houve redução da diferença salarial entre as regiões no período, favorecida pela queda significativa do efeito das dotações, mas os fatores regionais aumentaram a sua contribuição para o diferencial salarial, superando os atributos produtivos, sendo essenciais na explicação da desigualdade salarial entre as regiões brasileiras. Esses resultados reforçam a centralidade das especificidades locais nas temáticas salariais no país.
A pandemia da covid-19 e seus reflexos na cadeia produtiva do algodão orgânico
Authors: Fernandes Milene Ovando , Azevedo Denise Barros de , Casagranda Yasmin Gomes
Published: January 2023

Com a pandemia da covid-19, muitos setores produtivos foram impactados e tiveram de realizar mudanças para sobreviver no contexto de incertezas, incluindo a agricultura orgânica. Dessa forma, o objetivo da pesquisa foi evidenciar as mudanças na cadeia produtiva do algodão orgânico oriundas da pandemia da covid-19. A pesquisa se caracteriza pela abordagem qualitativa, a partir de estudo de caso na cadeia produtiva da cooperativa Justa Trama, que possui elos de produção em diferentes regiões do Brasil. A coleta de dados foi realizada a partir de entrevistas semiestruturadas com seis pessoas, uma de cada elo. Os dados foram interpretados utilizando a análise de conteúdo por categorias de análise, conforme palavras-chave predefinidas. Foi concluído que a pandemia alterou a forma de trabalho nos elos, porém não houve prejuízos à Justa Trama. Além disso, a cadeia produtiva do algodão orgânico está sujeita a alguns desafios, como a seca, falta de assistência técnica, pouco incentivo para aderir à produção orgânica e a dificuldade em encontrar mão de obra qualificada. Esses são pontos relevantes encontrados na pesquisa, que indicam a necessidade de acesso às políticas públicas e aos financiamentos pelos trabalhadores da cadeia produtiva.
Análise Multicritério para identificação de áreas prioritárias para irrigação, por meio de indicadores socioeconômicos, no contexto da Bacia Tocantins-Araguaia, Região Centro-Oeste do Brasil
Authors: Loreto Maria das Dores Saraiva de , Silva Aline Oliveira , Venâncio Luan Peroni , Moraes Camile Arêdes , Valadão Giovana Franco
Published: January 2023

Este artigo teve como objetivo identificar as áreas mais adequadas à implantação de sistemas de irrigação, na porção Centro-Oeste da Bacia do Tocantins-Araguaia, por meio da aplicação de Análise Multicritério, considerando indicadores socioeconômicos dos 178 municípios que compõem essa região. Metodologicamente, a partir da pesquisa bibliográfica e documental, os indicadores socioeconômicos foram selecionados em uma amplitude que permitisse uma caracterização econômica, demográfica, social e ambiental da bacia e, ao mesmo tempo, para delimitar áreas passíveis para projetos de irrigação, por meio de entrevistas com especialistas do campo da irrigação e Análise Multicritério. Os resultados evidenciaram que a bacia possui 29,2% da sua área com restrição à implantação de sistemas de irrigação. Por outro lado, mais de 70% da área da bacia apresentou uma classe alta e muito alta de aptidão, verificando-se que a região de maior aptidão se encontra, principalmente, na Região de Planejamento do Nordeste Goiano, considerada estratégica para investimentos, visando à minimização dos desequilíbrios regionais. Nesse sentido, é possível concluir que o método de Análise Multicritério se mostrou satisfatório para este estudo, facilitando a tomada de decisão, em consonância com os objetivos da Política Nacional de Irrigação, que visam promover o desenvolvimento local e regional, com prioridade para as regiões com baixos indicadores sociais e econômicos. Ou seja, os resultados podem contribuir para subsidiar as decisões sobre investimentos a serem realizados, dentro da perspectiva da responsabilidade social e do desenvolvimento sustentável, por meio do direcionamento àquelas áreas de maior vulnerabilidade e exclusão social.
Produção de leite de cabra e ovelha e seus derivados em Goiás e no Distrito Federal: análise dos direcionadores de competitividade
Authors: Heidorn Larissa Liane , Wander Alcido Elenor , De Souza Cleonice Borges , Holanda Junior Evandro Vasconcelos
Published: January 2023

A produção e o processamento de leite de pequenos ruminantes são alternativas de atividade econômica para pequenos empreendedores rurais e estão em expansão no Brasil. O presente artigo visa identificar a situação atual das cadeias de valor do leite de cabra e ovelha e seus derivados, em Goiás e no Distrito Federal, e analisar a competitividade dessas cadeias, por meio de uma comparação de seus direcionadores de competitividade com os de outras regiões do Brasil, onde essas cadeias estão mais estruturadas. Dessa forma, foi aplicado um questionário com 9 agentes-chave dessas cadeias dentro da região de estudo e 28 de outras localidades. Por meio da análise dos resultados, as cadeias de valor do leite de cabra e de ovelha e seus derivados em Goiás e no Distrito Federal foram caracterizadas como competitivas no momento do estudo. Contudo, os direcionadores “gestão da firma”, “tecnologia e inovação” e “qualidade” foram apontados como prováveis limitantes que precisam ser aprimorados para que essas cadeias permaneçam competitivas.
The Production Model of Tilapia (Oreochromis niloticus) Cultivation with System Dynamics Approach
Authors: Kurniawan Ade , Siegers Willem Hendry , Akbar Mohammad Aldrin , Nur Imran Syafei M.
Published: January 2023

The purpose of this study was to determine the survival rate (SR), the Average Daily Growth (ADG), and the Feed Conversion Ratio (FCR) of Nile tilapia (Oreochromis niloticus) with a dynamic system model. The dynamic system model is used to determine the optimal value of the three variables. The results showed that the survival rate, average daily growth, and feed conversion ratio of tilapia cultivation were 93% (SR), 3.2gr/day (ADG), 0.73 (FCR). In this research, tilapia  production were 14,199gr, the amount of feed were 10.344gr and the length of cultivation were 65 days. It was hoped that the dynamic system model design could have tilapia farmers to develop aquaculture businesses that was more environmentally friendly, effective and efficient.
Effect of Maggot on the IL-6 and IFN-Ɣ Expression of Koi Fish (Cyprinus carpio) Infected with Edwardsiella tarda
Authors: Wimala Niti Ida Ayu Kade , Maftuch Maftuch , Nurdiani Rahmi
Published: January 2023

The increase in koi fish cultivation can lead to increase risks and caused problems. The main problem is high disease attacks caused by the bacteria Edwardsiella tarda. One of the alternatives to control the disease is immunostimulant treatment with the use of maggot, Hermetia illucens Larvae, known as Black Soldier Fly (BSF). This study aims to report the effect of maggot as a substitute for koi fish feed formulations on the immune system of koi fish infected with E. tarda. This study used a descriptive method, by quantitative approach with the IL-6 and IFN-Ɣ expression through RT-PCR analysis and fish survival rate (%). Identification of E. tarda was carried out by the PCR test method at a molecular weight of 200 bp. The density of bacteria that caused the death of the 50% koi fish population (LD50) for 72 hours was 107 cells/ml. The highest IL-6 expression in the spleen was found in sample C of 28,844 and the lowest in-sample K (+) of 26,096. The highest IL-6 expression in the liver was in sample K (+) of 29,060 and the lowest was in sample D of 25,428. The highest IFN-Ɣ in the spleen was in treatment C, 28,844, and the lowest was in treatment D, 27,219. The highest IFN-Ɣ in liver was sample K (+) of 26,795, and the lowest in-sample C of 25,615. The survival rate of fish in this study reached 30%-100%. The optimal amount of substitution of maggot treatment is 75% (Treatment C) of fish feed.
The Mitogen-Activated Protein Kinase (MAPKs) Expression and Primary Stress Hormone (Cortisol) of Clarias sp. Juvenile in Different Light Intensity
Authors: Soeprijanto Agoes , Islamy R Adharyan
Published: January 2023

Clarias sp. is one of major genera of freshwater catfish and also common commodity in tropical aquaculture. Excessive light intensity is expected to be responded to by fish as environmental stressors. Fish that experience stress will increase the secretion of catecholamine, cortisol, blood glucose levels and p38 MAPKs in catfish. The different intensity of lights will affect the fish physiological processes. The purpose of this study was to analyze physiological responses (Level of blood glucose, primary stress hormone (Cortisol) and p38 MAPKs) catfish Clarias sp. which were incubated at different lights intensity of catfish. 300 fish were collected from Kepanjen Regency, East Java. Blood and meat sampling are carried out to test the profile of glucose, cortisol, and p38 MAPKs. The experimental research at this stage were carried out by transferred the catfish from Kepanjen to experimental aquarium (50 x 30 x 30 cm) that setted the different lights intensity (0 lux (control), 400 lux, 800 lux and 1200 lux). Each experimental aquarium is filled with 15 catfish and will be kept it for 21 days. Quantificationof the parameter using ELISA method. The study result showed highest peak of primary stress hormone (cortisol) levels are 34±1,50 ng/mL, blood glucose levels are 120±3,4 mg/dL, and p38 MAPK are 97±1,1 %. All of it were achieved in the treatment of 1200 lux on the 2nd week.
Survival Rate and Growth Length of Catfish (Clarias gariepinus) Exposed to Microplastics
Authors: Diana Permatasari  , Mohamad Fadjar  , Ating Yuniarti
Published: January 2023

Aquaculture has a land potential of 17.92 million ha consisting of 2.83 million ha of freshwater aquaculture potential, 2.96 million ha of brackish water aquaculture and 12.12 million ha of marine aquaculture. One of the freshwater species that has the potential to be cultivated is catfish (C. gariepinus). But now, as a result of the decline in the quality of the freshwater environment, catfish are prone to contamination by plastic waste. If microplastic particles have accumulated in large numbers in the fish's body, it can clog the fish's digestive tract and affect the growth of catfish which will affect the results of aquaculture production. The purpose of this study was to determine the survival rate or survival rate of catfish exposed to microplastics. The research design used in this study was a Completely Randomized Design (CRD) with 1 control variable, namely no mixing of microplastics in commercial feeds and 3 different doses of microplastics, namely A (5%), B (10%), C (15%) mixed with commercial feed, where each treatment was repeated 3 times. The results of the one way ANOVA analysis showed that the treatment of exposure to microplastics with different doses did not have a significant effect (P<0.05) on the survival rate and length growth of catfish. The survival rate ranges from 65- 100%. Survival values that were not significantly different could indicate that there was competition for space and dominance of larger fish in the aquarium which affected fish growth, feed utilization and fish survival. Meanwhile, the length growth value ranged from 21-28cm. The length growth value which was not significantly different could indicate that the dose of microplastic used in the study did not result in muscle and bone cell division which was the cause of the increase in body length of fish.
Effect of Giving Jackfruit (Artocarpus heterophyllus) Leaves Crude Extract as An Alternative Antibacterial of Edwardsiella tarda Bacteria In Vitro
Authors: Nilakandhi Tania , Prajitno Arief , Fadjar Mohammad , Hidayati Desy Amalia , Pratama Giri
Published: January 2023

Barriers to cultivation activities are disease attacks, one of which is caused by infection with the bacterium Edwardsiella tarda. Treatment efforts can be made using natural ingredients such as jackfruit (A. heterophyllus) leaves. This study aims to determine the content of antibacterial compounds in the jackfruit (A. heterophyllus) leaves crude extract and their effect on Edwardsiella tarda bacteria in vitro. The inhibition test used disc test with five different concentrations of jackfruit (A. heterophyllus) leaves crude extract with three replications: 75 mg/L, 150 mg/L, 225 mg/L, 300 mg/L and 375 mg/L with a comparison using two types of controls (positive with 5 mg/L chloramphenicol antibiotics and negative with no treatment) using Tryptone Soy Agar (TSA) media and incubated for 2x24 hours. The results of phytochemical screening proved that the jackfruit (A. heterophyllus) leaves crude extract contains flavonoids, alkaloids, tannins and saponins. Treatment E with a dose of 375 mg/L gave the highest inhibition of 7.80 mm and treatment A with a dose of 75 mg/L gave the lowest inhibition of 4.38 mm.  The relationship between the treatment given to the test parameter in the form of the resulting inhibitory power obtained the equation y = 0.0111x + 3.6297 with an R2 value of 0.974 which means 97% of the treatment given in the form of crude extract of jackfruit (A. heterophyllus) leaves affects inhibition of bacteria E. tarda.
Strategy for the Development of Sustainable Vannamei (Litopenaeus vannamei) Shrimp Culture in Plastic Ponds in Tegal Regency, Central Java
Authors: Purwanto Purwanto , Sarjito  , Wijayanto Dian
Published: January 2023

Vannamei shrimp culture is a fishery sub-sector that is being promoted by the Indonesian government. The vannamei shrimp culture great bussiness prospect makes many farmers to carry out these business activities. However, if the culture business is carried out in an environmentally unfriendly way, the sustainability of the business will stop. The purpose of this study is to determine the correct strategy for the development of vannamei shrimp culture in plastic ponds in Tegal Regency, Central Java. The research method used is the survey method with purposive sampling, the respondent sampling technique is non probability sampling and data collection with interviews, questionnaires, observation and documentation. The data obtained were analyzed descriptively and SWOT. The number of respondents was 38 people. The results indicated that the production of vannamei shrimp has decreased in the last three years due to Acute Hepato Pancreatic Necrosis Disease outbreak. A calculation matrix factor strategy internal (IFAS), strength (S) biggest are good and correct culture SOPs (0.349) and the calculation of the external strategy matrix (EFAS), opportunities (O) the largest is the large market goose p (0,293). Relationship factor occupy cell V, from effort the describe the situation growth and stability which means that the business is in a relatively stable condition and growth is likely to occur. Based on the SWOT analysis, the ranking of alternative strategies obtained is the SO strategy (Strengths – Opportunities) with total score of 3,602. Priority alternative strategy which used is optimizing the quality and quantity of products by using good and correct SOP, using technology, available infrastructure and availability of adequate seeds to produce quality and quantity of products so that continuity is maintained, so as to meet high market and consumer demand.
Optical Properties of Composite Silver Nanoparticles
Authors: Ali Ibrahim Elagib , Almutairi Wafa Sultan
Published: January 2023

Abstract

composite silver nanoparticles were synthesised using melanin broth and Arabic gum as a reducing and binding agent. The reactions are carried out with water because it is a non-hazardous solvent. The produced composites either had specified diameters (average diameter of 50 nm) with high silver loading or lower loading composites with tuneable morphologies and electrical properties. UV-IR, gamma, and conventional light are used to characterise the synthesised composite silver nanoparticles. Furthermore, measurements are carried out of the dielectric constant, refractive index, energy gap, optical and electrical conductivities, and refractive index coefficients. The silver nanoparticle formation was validated by UV-Vis measurement of the sample, which demonstrated a distinct peak at a wavelength of 420 nm. The characteristics of the composite silver nanoparticles are also quantified using several methods, including XRD, SEM, and particle size analysis.
Quantitative Image Processing for Three-Dimensional Episcopic Images of Biological Structures: Current State and Future Direction
Authors: Holroyd Natalie Aroha , Walsh Claire , Gourmet Lucie , Walker-Samuel Simon
Published: January 2023

Episcopic imaging using techniques such as High Resolution Episcopic Microscopy (HREM) and its variants, allows biological samples to be visualized in three dimensional over a large field of view. Quantitative analysis of these images is undertaken using a range of methods. In this systematic review, we look at trends in quantitative analysis of episcopic images and discuss avenues for further research. Papers published between 2011 and 2022 were analyzed for details about quantitative analysis approaches, methods of image annotation and choice of image processing software. It is shown that quantitative processing is becoming more common in episcopic microscopy and that manual annotation is the predominant method of image analysis. Our meta-analysis highlights where tools and methods still require development in this field, and we discuss what this means for the future of quantitative episcopic imaging, as well as how annotation and quantification may be automated and standardized across the field.
Plant-based Bone Grafting: The Future of Bone Healing
Authors: Pinheiro Camila Silva de Morais , De Carvalho  Neta Alcina Vieira , Pinheiro Neto Vicente Ferrer , Oliveira Claudia Quintino da Rocha , Ribeiro Rachel Melo , Borges Antônio Carlos Romão , Borges Marilene Oliveira da Rocha
Published: January 2023

Objectives Bone fractures are very common diseases, which can be caused by impact injuries or physiological disorders. Thus, the present review aimed to study the use of medicinal plants in the healing mechanism of bone fractures. Evidence acquisition Through research in the PubMed, Google Academic, and Scielo databases, this article reviews 11 ethnopharmacological studies and 34 preclinical studies on the biological actions of different plants in bone fracture healing mechanism. Results Indian tribes have highlighted in the plants ethnopharmacological study for various diseases, including bone fractures. However, despite the large citations of traditional use, technical-scientific studies are still scarce in the literature. Chenopodium ambrosioides, Piper sarmentosum, quadrangular Cissus, Ricinus communis and Radix salvia miltiorrhiza plants were the most studied in the literature regarding their osteogenic, angiogenic, anti-inflammatory and remodeling effects, acting on bone receptors, stimulating bone metabolism, increasing minerals uptake, and assisting in free radicals breakdown. Conclusion Thus, the medicinal plants use is promising in the field of bone regeneration, as well as being alternative when conventional therapies are unfeasible, increasing herbal medicines demand and popularity.
Perceptions and Intention of Healthcare Workers’ to Vaccinate Their Children Aged <18 Years against COVID-19 from A Tertiary Care Institute of Eastern Uttar Pradesh (U.P.), India
Authors: Khan Imran Ahmed , Bashar MD. Abu , Kumar Rupam
Published: January 2023

Abstract Background COVID-19 vaccination program among Adults in India is one of the highly successful vaccination drives globally. Indian children aged 15–18 years old became eligible for COVID-19 vaccination on 3rd January, 2022 followed by 12-14 years old children on 16th March, 2022. As parents are primary decision-makers for their children, we aimed to assess parents' perceptions and intentions regarding COVID-19 vaccination for children in India. Aim To assess parental perceptions and intention to get COVID-19 vaccination for their children (aged<18 years), Materials and Methods A cross-sectional anonymous web-based survey was designed. Healthcare workers of a tertiary care institute in Eastern U.P. having any children aged <18 years were the study population. They were recruited through snowball sampling and were sent the study questionnaire in Google form through email and WhatsApp. Cross-tabulation was performed by parents' intention to vaccinate their children against COVID-19 virus with socio-demographic characteristics and their risk perception toward COVID-19, trust in the healthcare system, and their history of vaccine hesitancy behavior routine childhood immunization. Bi-variate analysis was performed to find out the predictors of child vaccination intention among the parents. Results A total of 388 healthcare workers parents (HCWPs) having A child < 18 years of age completed the survey. Mean age of the parents were 40.28 ±11.34 years with majority(97.0%) completing recommended 2 doses of COVIID-19 vaccine. Around 91% of the parents agreed that COVID-19 vaccines are important for child’s health whereas about 89% agreed to the statement that COVID-19 vaccines are effective. A total 356 (91.7%) participants were willing to vaccinate their child against COVID-19, 91.3% of them liked to do so as soon as possible. The factors significantly associated with the stated likelihood of child vaccination among the participants were younger age, female gender, urban residence, absence of any chronic illness, lower monthly income, history of COVID-19 in child and the child/children completed with routine childhood vaccines. Parental concerns mainly centered around vaccine need, safety and side effects. Conclusion The healthcare worker parents(HCWPs) have good knowledge and positive attitude towards COVID-19 vaccination for children. Around 92% of them were willing to vaccinate their children with COVID vaccine currently, which implies very low vaccine hesitancy among the HCWPs . Further longitudinal studies are required to be conducted to assess the trend of parental acceptance of COVID vaccine.