bluuebunny/crossref_metadata_2025 huggingface dataset:
Reflections on Australian DCD lung donation and transplant journey
Report from the 38th Annual Meeting — International Society for Heart and Lung Transplantation, Nice, France: 11–14 April 2018
Authors: Levvey Bronwyn
Published: May 2019

‘10 Years On: The Significant Impact of Controlled DCD Lung Donors on Lung Transplant Opportunities and Outcomes’
Purpose Since 2006, the Alfred Hospital has increasingly utilised controlled DCD donor lungs to optimise LTx opportunities and reduced waiting list (WL) deaths. This study evaluated the impact of DCD donation on LTx WL time and mortality, and compared post-LTx outcomes of DCD and contemporaneous DBD LTx performed over the first 10 years.
Method This was a retrospective analysis of all LTx done at our institution between May 2006 and February 2017 (n=696, 150 DCD LTx, 546 DBD LTx) was undertaken. WL time/mortality, donor and recipient demographics, early outcome measures, survival and cause of death were compared. Our institution regularly utilises extended DCD and DBD donor lungs; however, it does not yet routinely utilise ex-vivo lung perfusion (EVLP) to evaluate these extended donor lungs, unlike many programs in the USA and Europe.
Results The use of DCD donors has resulted in 25% more LTx annually, reduced overall WL times (245 to 135 days, p<0.001) and WL mortality (29% to 5%, p<0.01) from 2006 to 2017 respectively. Compared to DBD, DCD donors were intubated in ICU Longer (115 vs 79hrs, p<0.01), were older (45 vs 41 yrs, p<0.01) and were less commonly distant (>300 km) donors (20% vs 35%, p<0.01). DCD recipients compared to DBD had a reduced WL time (101 vs 120 days, p=0.03) and longer graft ischaemic time (323 vs 287 mins, p<0.01). There was no difference in intensive care unit (ICU) or hospital length of stay between DCD and DBD; and importantly, no significant difference in 1, 5 or 10 year survival rates comparing DCD vs DBD (96%, 69% and 53% vs 92%, 64% and 51% respectively, p=ns).
Conclusions Controlled DCD donation has significantly and safely increased overall LTx numbers, without reducing DBD LTx (Figure 1), and has also reduced WL time and mortality with excellent 1, 5 and 10 year LTx survival for both DCD and DBD LTx compared to ISHLT at our institution (Figure 2). Importantly, our results also show that EVLP is not required for a successful utilisation of DCD donor lungs for LTx.
Finding reviewer for editorial process: A challenge to resolve
Authors: Iqbal Md Ashif
Published: May 2019

Abstract not available

Update Dent. Coll. j: 2019; 9 (1): 1-2
PENINGKATAN KETERAMPILAN MENULIS NASKAH DRAMA DENGAN MENGGUNAKAN MEDIA LINE WEBTOON PADA SISWA KELAS VIII SMP NEGERI 1 KOTA BENGKULU
Authors: Oktarina Silpani , Susetyo Susetyo , Gumono Gumono
Published: May 2019

Tujuan penelitian ini untuk mendeskripsikan tentang peningkatan keterampilan menulis naskah drama pada siswa kelas VIII SMP Negeri 1 Kota Bengkulu menggunakan media line webtoon. Penelitian ini merupakan penelitian tindakan kelas dengan model Kemmis dan Mc.Taggart. Subjek dalam penelitian adalah siswa kelas VIII-7 SMP Negeri 1 Kota Bengkulu yang berjumlah 35 orang dan dilaksanakan dalam dua siklus. Hasil penelitian pada siklus I diperoleh nilai rata-rata sebesar 70,1 dengan ketuntasan belajar secara klasikal 25,71%. Perolehan hasil menulis naskah drama siswa rata-rata masih rendah pada kriteria penilaian dialog, alur dan petunjuk teknis pada siklus I. Pada siklus II diperoleh nilai rata-rata sebesar 83,3 dengan ketuntasan belajar secara klasikal sebesar 80%. Kesulitan siswa dalam menulis naskah drama pada siklus sebelumnya dapat teratasi dengan baik pada siklus II dengan meningkatnya kenaikan skor sebesar 13,2 dan ketuntasan belajar klasikal sebesar 54,12%. Penggunaan media line webtoon dapat menarik minat siswa dalam pembelajaran menulis naskah drama dan meningkatkan hasil penulisan naskah drama yang telah dilakukan selama 2 siklus.Kata kunci: keterampilan menulis, naskah drama, line webtoon.
PENGARUH PEMBELAJARAN COOPERATIVE PROBLEM SOLVING TERHADAP KEMAMPUAN PEMECAHAN MASALAH FISIKA SISWA DI SMAN 1 KEPAHIANG
Authors: Avico Indra , Purwanto Andik , Putri Desy Hanisa
Published: May 2019

Penelitian ini bertujuan untuk  mengetahui perbedaan pembelajaran Cooperative Problem Solving dengan Pembelajaran Konvensional terhadap hasil belajar fisika siswa dan menjelaskan ada atau tidaknya pengaruh pembelajaran Cooperative Problem Solving  terhadap kemampuan pemecahan masalah siswa di SMA Negeri 1 Kepahiang. Jenis penelitian ini adalah experiment research dengan desain posttest-only control design untuk mengukur hasil belajar siswa dan desain penelitian one group pretest postest design untuk mengukur kemampuan pemecahan masalah fisika siswa. Sampel penelitian diambil menggunakan purposive sampling yang diperoleh kelas X IPA 1 sebagai kelas eksperimen dan kelas X 1PA 2 sebagai kelas kontrol. Hasil analisis data menggunakan Uji-t dua sampel independen menunjukkan bahwa tidak terdapat perbedaan yang signifikan antara penggunaan Pembelajaaran Cooperative Problem Solving dan Pembelajaran Konvensional terhadap hasil belajar siswa dengan thitung = 0.9138<ttabel =1.9983. Sedangkan penggunaan pembelajaran Cooperative Problem Solving terhadap kemampuan pemecahan masalah siswa di SMAN 1 Kepahiang berpengaruh kuat dengan perhitungan effect size yaitu 5.779.Kata Kunci: Pembelajaran Cooperative Problem Solving, Kemampuan Pemecahan Masalah, Pembelajaran Konvensional, Hasil Belajar.
HUBUNGAN KECERDASAN INTELEKTUAL DAN HASIL BELAJAR FISIKA SISWA KELAS XI IPA SMA
Authors: Sari Putri Eka , Koto Irwan , Sakti Indra
Published: May 2019

Penelitian ini  bertujuan untuk (1) mendeskripsikan kecerdasan intelektual kelas XI IPA, (2) mendeskripsikan hasil belajar fisika siswa kelas XI IPA, dan (3) mengetahui hubungan antara kecerdasan intelektual dengan hasil belajar fisika siswa kelas XI IPA. Penelitian ini menggunakan metode korelasional dengan pendekatan regresi linier sederhana. Populasi adalah siswa Kelas XI IPA, dengan sampel penelitian adalah siswa kelas XI IPA 1, XI IPA 2 dan kelas XI IPA 5, yang ditentukan dengan teknik purposive sampling dengan jumlah 78 siswa. Instrumen yang digunakan adalah tes IQ yang diperoleh dari dokumentasi sekolah dan hasil belajar fisika merupakan data hasil Ujian Akhir Semester (UAS) tahun pelajaran 2017/2018. Analisis data menggunakan regresi linier sederhana dengan kecerdasan intelektual (X) sebagai variabel independent dan hasil belajar fisika  (Y) sebagai variabel dependent. Hasil penelitian menunjukkan bahwa tingkat kecerdasan intelektual siswa  kelas XI IPA pada kategori normal rata-rata (55,13 %). Nilai hasil belajar fisika adalah 90% siswa memperoleh nilai dibawah KKM (75), hasil ini merupakan data nilai mentah dari ujian akhir semester. Berdasarkan uji statistik diperoleh rxy (0,639)  >  rtabel (0,227),  Fhitung  (7,0286) > Ftabel (3,96) pada taraf signifikansi 5% (0,05). Variabel kecerdasan intelektual memberikan sumbangan 40,8 % terhadap hasil belajar fisika siswa kelas XI IPA. Sedangkan 59,2% dipengaruhi oleh faktor-faktor lain yang belum terungkap dalam penelitian ini. Disimpulkan bahwa terdapat korelasi  positif yang signifikan antara kecerdasan intelektual dengan hasil belajar fisika siswa kelas XI IPA SMA Negeri 01 Bengkulu Utara tahun ajaran 2017/2018.Kata kunci : metode korelasional, kecerdasan intelektual,  hasil belajar fisika
PROTOTYPE ALAT PENDETEKSI DAN PENGUSIR TIKUS PADA PEMBIBITAN KELAPA SAWIT BERBASIS ARDUINO UNO
Authors: Rukmana Susi Tarwianti Endra , Mayub Afrizal , Medriati Rosane
Published: May 2019

Penelitian ini bertujuan untuk menghasilkan rancangan pengembangan prototype alat pendeteksi dan pengusir tikus pada pembibitan kelapa sawit berbasis Arduino Uno. Penelitian ini menggunakan metode penelitian Research and Development. Tahapan dalam penelitian ini meliputi: perencanaan, produksi dan evaluasi. Alat pendeteksi dan pengusir tikus pada pembibitan kelapa sawit ini tersusun oleh komponen-komponen elektronik, seperti sensor PIR sebagai pendeteksi pergerakan tikus, Arduino uno sebagai pengendali utama sistem dan penghubung  modul GSM SIM900A. GSM SIM 900A berfungsi untuk alat komunikasi antara alat dengan user dalam satu arah. Alat pendeteksi dan pengusir tikus ini akan mengusir tikus dengan menggunakan suara yang dikeluarkan oleh speaker dari audio generator dengan frekuensi ultrasonik. Berdasarkan pengujian yang telah dilakukan pada alat yang dibuat, didapat bahwa prototype alat pendeteksi dan pengusir tikus pada pembiitan kelapa sawit berbasis Arduino Uno layak untuk digunakan untuk mendeteksi dan mengusir tikus. Kata kunci: sensor PIR, Arduio Uno, GSM SIM900A, Audio Generator, Research and Development (R&D)
Hubungan Karakteristik Pembudidaya Ikan terhadap Adopsi Inovasi Pakan Alami Ikan di Kecamatan Darmaraja Kabupaten Sumedang
Authors: Darwita Nisfi , Danapraja Sopiyan , Leilani Ani
Published: May 2019

Penelitian ini bertujuan untuk: (1) mengetahui keeratan hubungan karakteristik pembudidaya terhadap tingkat adopsi inovasi pakan alami ikan (2) mengetahui tingkat adopsi inovasi berdasarkan kelas kelompok. Penelitian dilakukan di Kelompok Mina Mukti dan Kelompok Cipta Rasa Kecamatan Darmaraja Kabupaten Sumedang, pada bulan Februari sampai Mei 2018. Teknik pengumpulan data menggunakan kuesioner, wawancara, dan observasi sedangkan teknik analisis data menggunakan analisis deskriptif. Hasil penelitian menunjukkan bahwa: (1) Karakteristik pembudidaya seperti umur, pendidikan, lama usaha, luas lahan dan pendapatan berhubungan dengan tingkatadopsi inovasi pakan alami ikan; (2) Tingkat adopsi inovasi pada kelompok madya (Mina Mukti) lebih tinggi dibandingkan kelompok pemula (Cipta Rasa).
Peningkatan Hasil Belajar Kognitif Siswa Melalui Model Pembelajaran Kontekstual Pada Materi Perkalian dan Pembagian
Authors: Dores Olenggius Jiran , Bustami Yakobus , Ana Rupina Mila Maria
Published: May 2019

The Enhancement of Students' Cognitive Learning Achievement Through Contextual Learning Model on Multiplication and Division’s Matter. This research was based on the number of students who produce the resuits of cognitive learning under minimal mastery. The purpose of this research was to improve student cognitive learning outcomes and improve the learning process by applying the contextual learning model. The approach used in this research was descritptive qualitative approach with classroom action research method consisting of two cyeles. Subjects in this researchwere the students of elementary school  classs III 48 Lepung Beruang were 43 students who taught  by the modeling of contextstual. The instrument for measuring cognitive learning outcomes. The data obtained were analyzed by using desctiptive whit mean and Classical completeness value. The result of descriptive analysis shows that in cycle I, the result of 29 students is complete with an average of 66,00 and classical completeness of 67,44%. Furthermore, in cycle II, students who complete 37 students with average of 78,60 and classical completeness of 86,04% of students into good category. The results of this study can be concluded tahat the modeling of use can improve student learning outcomes on mathematic materials.Based on, the result of the teacher activity observation has been received 60% the first meeting, 65% the second meeting on the first cycle, meanwhile  on the second cycle at the  first meeting has got constantly becoming increasing 100%. The results of this research can be concluded that the use of contextual learning can improve the cognitive learning outcomes of students in multiplication and division material and improve the learning process of learning
Developing Students’ Vocabulary through Watching English Cartoon Films at SMP BHAKTI
Authors: Christopley Christopley
Published: May 2019

AbstractThis was a research report on developing students’ vocabulary through watching English cartoon films. The objectives of this research were to develop students’ vocabulary and students’ responses on learning vocabulary through watching English cartoon film at SMP BHAKTI, Jakarta. This research used classroom action research (CAR) method in which the students consisted of 23 eighth graders of SMP BHAKTI, Jakarta and comprised15 males and 8 females. To collect the data the researcher used test and non-test techniques. The test technique was realized in pre-test and post-test; while the non-test one was in questionnaire, observation sheet, and diary notes. Based on the test analysis results, it was found that the mean score of the pretest, post-test in Cycle 1 and 2 were 60.73 points, 80.86 points, and 90.00 points respectively. The gain between the post-test and pre-test scores in Cycle 1 was 33.14% and the gain between the post-test in Cycle 1 and post-test scores in Cycle 2 was 11.30%. The gain between pre-test and post-test scores in Cycle 2 was 48.69%. Therefore, it can be concluded that watching English cartoon films could develop the eighth graders’ vocabulary of SMP BHAKTI, Jakarta. Besides, based on the questionnaire, observation sheet, and diary notes analysis results, it was revealed that students agreed that watching English cartoon films was a good strategy to develop their vocabulary. The conclusion is that watching English cartoon films can develop students’ vocabulary.Keywords: English cartoon films, vocabulary, action research
Acute Glycemic Changes in Brain and Subcutaneous Tissue Measured by Continuous Glucose Monitoring System in Hereditary Hypertriglyceridemic Rat
Authors: ŽOUREK M. , KYSELOVÁ P. , ČECHUROVÁ D. , RUŠAVÝ Z.
Published: May 2019

Parallel glucose measurements in blood and other different tissues give us knowledge about dynamics of glycemia changes, which depend on vascularization, distribution space and local utilization by tissues. Such information is important for the understanding of glucose homeostasis and regulation. The aim of our study was to determine the time-lag between blood, brain, and adipose tissue during rapid glucose changes in a male hHTG rat (n=15). The CGMS sensor Guardian RT (Minimed/Medtronic, USA) was inserted into the brain and into the abdominal subcutaneous tissue. Fixed insulin and variable rate of glucose infusion was used to maintain euglycemia during sensor calibration period. At 0 min, 0.5 g/kg of bolus of glucose was administered, and at 50 min, 5 IU/kg of bolus of insulin was administered. Further glucose and insulin infusion was stopped at this time. The experiment was finished at 130 min and animals were euthanized. The time-shift between glycemia changes in blood, brain, and subcutaneous tissue was calculated by identification of the ideal correlation function. Moreover, the time to achieve 90 % of the maximum glucose excursion after intervention (T90) was measured to compare our data with the literature. The time-lag blood vs. brain and blood vs. subcutaneous tissue was 10 (10; 15) min and 15 (15; 25) min, respectively. The difference was statistically significant (P=0.01). T90 after glucose bolus in brain and subcutaneous tissue was 10 min (8.75; 15) and 15 min (13.75; 21.25), respectively. T90 after insulin bolus in brain and subcutaneous tissue was 10 min (10; 15) and 20 min (20; 27.5), respectively. To the contrary, with literature, our results showed earlier glucose level changes in brain in comparison with subcutaneous tissue after glucose and insulin boluses. Our results suggest that glucose dynamics is different within monitored tissues under rapid changing glucose level and we can expect similar behavior in humans. Improved knowledge about glucose distribution and dynamics is important for avoiding hypoglycemia.
The Blyton Brexit parodies
Authors: Edwards Owen Dudley
Published: May 2019

This essay uses Bruno Vincent's Five Brexit parodies to unpick Enid Blyton's wider legacy in British culture, and to understand our contemporary politics.
UTILIZING HOUSE YARDS TO GROW PRODUCTIVE CROPS AT PELAMBUAN SUB-DISTRICT, BANJARMASIN MUNICIPALITY
Authors: ANITA Andi Suci , ZUBIR Edward , AMANI Mukhyar
Published: May 2019

Improving people’s welfare is the main goal of development, which can be achieved among others through the intensive use of house yards. Every community member owns a yard at their house. This activity is done in collaboration with housewives who are not working at Pelambuan Selatan sub-district, Banjarmasin, who have irregular monthly incomes. House yards are used effectively to cultivate vegetables and medicinal plants on organic media which are arranged vertically. Such use is expected to be able to help families meeting their daily nutritional needs or in case they need medicinal aids. This activity is also expected to be sustainable so that the yield can be sold for some extra household income. The methods applied in this program include (1) Dissemination on the Utilization of House Yards, Planting Techniques, and Information on Vegetable Crops and Medicinal Plants; (2) Provision of vegetables and medicinal plants seedlings and seeds, growing media, watering cans, and plant racks; (3) Mentoring to the partners on the process of seedling, planting, and maintenance
Evolution of European Union’s policy towards the Mediterranean region
Authors: Diawol Anna
Published: May 2019

This paper examines some specific problem in Euro Mediterranean relation. Author decided to concentrate on two main issues: the characteristics of the institutions of the Union for the Mediterranean, indicating similarities and differences in the Euro-Mediterranean programs and the presentation of specific new initiatives. The author will also summarize the main possible positions in the ongoing debates about the need to reform the European Union addressed to the countries of North Africa and the Middle East.
Some context of the multifunctional agricultural and sustainable rural development
Authors: Horváth Péter , Nagy Géza
Published: May 2019

The paper first negotiates the concept of multifunctionality, then the main steps of the development of the connection between agriculture and rural development are discussed. It presents the situation of a most disadvantageous sub-region that is aided by a complex program. The local rural resources are estimated by the multifunctional rural resource analysis method considering threefold function of the rural areas. It is concluded, that the land use systems and labour-intensive cropping systems have specific missions in multifunctional agriculture and rural development in the sub-region.
Participation of Women in the United States Congress: 1917-2011
Authors: Chojnacka Magdalena
Published: May 2019

The last decades have carried changes in the legal and social position of women bearing enfranchisement, a new approach to women’s education, and their increased participation in the job market. This article outlines the historical participation of women on the political scene of the United States between the years of 1917-2011 including an analysis of the situation in the individual states. Furthermore, it analyses what types of positions have been held by women in the American Government Administration including the most prestigious ones of the Speaker and the Secretary of State. It also introduces Hilary Rodham Clinton, the first woman ever to run in the presidential elections 2008. This analysis reveals that women are still underrepresented in the federal-level positions which makes it difficult for them to influence the quality of the lawmaking and results in a difficulty to promote such decisions that are important for the women themselves.
Viewboard Effectiveness on Raharja Internet Cafe Website as Sales Information Submission Media
Authors: Nurhaeni Tuti , Karts Kawl W , Hardini Marviola
Published: May 2019

Information is a key to success in communicating. Communication will not be possible without information. But if the information we convey is wrong it will cause a problem. At Raharja University there is a facility that provides needs services to students such as searching for material, printing, scans, and binding documents, there are also accessories and service places if there are students who have problems with the equipment given for study, Raharja Internet Cafe. Raharja Internet Cafe has a website to be used by students who want to order their needs. However, the admin who maintains Raharja Internet Cafe cannot monitor what products or goods are the best-selling or the most sold because they are not well monitored. With no monitoring of the admin sales process or the guard cannot report the goods to the University, or the conventional data recording process. These problems are certainly considered ineffective because Raharja University is engaged in technology in each of its lecture activities. Creating a viewboard on the Raharja Internet Cafe website as a medium for delivering sales information is the solution. The method that I use is a method of data collection namely observation and literature study and a qualitative approach. The results of this study are that the presence of a viewboard on the Raharja Internet Cafe website can facilitate the admin or guard of Raharja Internet Cafe to make a report to the Raharja University.
Gadgetku.id application as a Solution to Facilitate the Fulfillment of All Gadget Needs today (case study: area Tangerang Banten)
Authors: Sutrisno Sutrisno , Sajidin Ahmad Ajie
Published: May 2019

The gadget is a sophisticated item that can present a variety of news media, social networking, hobbies, and even entertainment. The presence of gadgets today makes some people become dependent. If the gadget is damaged, they will repair the gadget itself or bring it to the service place. The problem in this study is the difficulty of finding information about the place of seller of gadget components and looking for a trusted service place, the nearest location and affordable prices. To overcome this problem, the author designed an application called Gadgetku.Id used a qualitative research method consisting of data collection, data analysis and system design. In this application have 2 main services, namely service and shop. The purpose of designing this application is to be able to assist users in finding a trusted service place, the nearest location, safe, scheduled and without the need to go to the service place and help to find gadget needs through the shop feature.
VULNERACIÓN DEL DERECHO AL DEBIDO PROCESO EN LA APLICACIÓN DEL PROCEDIMIENTO ABREVIADO EN MATERIA PENAL
Authors: Chamba Aguilar Yolanda Elizabeth , Alexandre Preciado Shirley Patricia , Vilela Pincay Wilson Exson
Published: May 2019

El siguiente artículo tiene como objetivo analizar la constitucionalidad de las normas del COIP. Estas, son relativas al procedimiento penal abreviado en el cumplimiento de las garantías al derecho del debido proceso. Por ello, se desarrolló un estudio descriptivo de tipo revisión bibliográfica. Además, se propone una estrategia metodológica que responde al paradigma cualitativo. Sobre esta base, fue necesario la utilización de los métodos de investigación científica: exegético y analítico–sintético. Asimismo, el empleo de la técnica de análisis de contenido. Consecuentemente, las entrevistas realizadas permitieron determinar qué el procedimiento abreviado compromete varios derechos, garantías y principios consagrados en la Constitución y en el Pacto de San José de Costa Rica. Los mismos son: los Derechos Humanos al violentar el derecho de toda persona sindicada a no ser obligada a declarar en contra de sí misma; la presunción de inocencia; el principio de carga de la prueba; el principio de igualdad de armas; el principio de justicia; la certeza efectiva de la culpabilidad; el plazo razonable y la acreditación de la verdad procesal. Lo anterior, evidencia la existencia de fisuras en el procedimiento abreviado que contradice el postulado de un auténtico Estado de derecho y de justicia.
TÜRKİYE VE AB ÜLKELERİNDE ANTİBİYOTİK KULLANIMI VE DIŞ TİCARET DENGESİ ÜZERİNE BİR DEĞERLENDİRME - AN EVALUATION ON ANTIBIOTIC USE, ANTIBIOTIC RESISTANCE AND TRADE BALANCE IN TURKEY AND EU COUNTRIES
Authors: Kılıç Esin , Yenilmez Füsun
Published: May 2019

Bu çalışmada, Türkiye
ve AB ülkelerinde antibiyotik kullanımının antibiyotik direnci ve dış ticaret
dengesi üzerindeki etkileri değerlendirilmektedir. Çalışmada elde edilen
bulgular, 2005-2015 döneminde Türkiye'de antibiyotik kullanımının AB
ortalamasına göre yüksek olduğunu işaret etmiştir. Ayrıca bu çalışma ile yüksek
antibiyotik kullanımının antibiyotik direncini 
tek etken olmadığını, antibiyotik kullanımı artışlarının ve eğitimin de
antibiyotik direncinin önemli belirleyicileri olduğu ortaya konulmuştur.
Ayrıca
ilaç ihracat gücüne sahip olmayan AB ülkelerindeki yüksek antibiyotik
kullanımının dış ticaret dengesini bozucu etkileri belirlenmiştir.
MESLEKİ DERMATOZLARIN HALK SAĞLIĞI AÇISINDAN ÖNEMİ
Authors: Oğuz Topal İlteriş
Published: May 2019

Mesleksel
dermatozlar mesleksel aktiviteler ve iş durumlarından kaynaklanan bir grup
hastalıktır. 2004 yılında yayınlanan bilgiye göre sanayileşmiş ülkelerde tüm
mesleksel hastalıkların %30’dan fazlasını deri hastalıkları oluşturmaktadır ve
bu deri hastalıklarının %90’nını kontakt dermatitler oluşturmaktadır. Allerjik
kontakt dermatit ve irritan kontakt dermatit en sık görülen mesleksel
dematozlardır. Tanı öykü, klinik bulgular ve patch test gibi bazı testler ile
konulur. Britanya’da  Sağlık ve Güvenlik
Komisyonu 2006/2007’de yaklaşık 23.000 işçide 
(100.000 işçide 78) deri hastalığı olduğunu tahmin etmiştir. Mesleksel
dermatozlar işçilerin yaşam kalitesi ve sosyal aktivitelerini etkileyebilir ve
çalışılmayan günler, üretkenlik kaybı, maluliyet ödemeleri ile ilişkili olarak
mali kayba yol açabilir. Uluslararası Çalışma Örgütü’ne göre meslek
hastalıkları  ve yaralanmalar toplam yurt
içi gelirinin yıllık %4’nün kaybına yol açar. Ülkemizde mesleksel dermatozların
tanısı ve bildirimi ile ilgili bazı problemler vardır. Bildirim ile ilgili
gerekli tedbirlerin alınması önemlidir. Bu hastalıkları önlemek için
düzenlemeler gereklidir. İşverenler iş yerinde koruyucu önlemler almalı,
gerekirse  mesleksel hastalıkları
bildirmelidir. İşçiler ve doktorlar mesleksel dermatozların farkında olmalı, bu
hastalıklar ile ilgili eğitim almalıdır. Doğru stratejilerin belirlenmesi ile
mesleksel dermatozlar azalacak ve olumsuz sonuçlar önlenecektir
ÇEVRESEL ETKENLER VE DERİ HASTALIKLARI
Authors: Önsüz Muhammed Fatih
Published: May 2019

Vücudun
en büyük organı ve çevre ile ilk temas yeri olarak deri çevresel etkenlerden en
çok etkilenen organlardan biridir. Literatürde de deri hastalıklarının
oluşumunda çevresel etkenlerin etkileri belirtilmektedir. Güneş ışığı ve
ultraviyole başta olmak üzere fiziksel çevresel etkenler deride hastalık
oluşturabilir. Bazı metaller, asit ve alkaliler, solventler, pestisidler ve
katran gibi kimyasal çevresel etkenler de önemli deri hastalığı etkenleridir.
Ayrıca biyolojik ve psikososyal çevresel etkenler de deri hastalıklarına neden
olabilmektedirler. Çevresel etkenlerin neden olduğu deri hastalıkları
içerisinde dermatitler, deri yaşlanması, psöriazis, akne, pigmentasyon
problemleri, kanser vb. birçok hastalık sayılabilir.
Making Sense of δήλωμα (Plato’s Cratylus, 423 b and Beyond)
Authors: Bergomi Mariapaola
Published: May 2019

In this paper I aim to discuss the notion of δήλωμα which can be found for the first time in the extant Greek literature in Plato, Cratylus 423 b, by analysing the philosophical argument of bodily imitation and language. I aim to show that this portion of text in particular contains extraordinary original material which has no parallel in other Platonic works. I shall also discuss the notion of δήλωμα in critical relation to μίμημα and σημεῖον, with reference to the Cratylus, the Sophist and other philosophical works posterior to Plato.
Nicknames among Greeks of the Archaic and Classical Periods: Preliminary Thoughts of a General Theoretical Nature
Authors: Surikov Igor
Published: May 2019

This article is the first in a series devoted to nicknames of well-known people in Greece of pre-Hellenistic times. In it general considerations are primarily expressed about the role of nicknames in human societies (including ancient Greek), relations of nicknames to personal names and divine epithets, terminology of nicknames among the Greeks, and the possible reasons for not very broad development of the practice of nicknaming in Greece during this period.

A nickname is a fundamental phenomenon of the history of culture, and its real significance has not yet been appreciated. Nicknames in particular served as means of distinguishing individuals within any society. The names of the ancient Greeks had originally resembled nicknames as much as possible. Onomastic units in Greek poleis were mostly meaningful.

Nicknames can be assigned—not from a semantic but rather from an emotional point of view—to three basic types. We deal with nicknames of a) a positive, exalted character (“Olympian” as to Pericles); b) a negative, pejorative character (“Coalemos”—“Simpleton” as to Cimon the Elder); c) a neutral character—those that show a certain characteristic appearance of an individual (e.g., “One-Eyed”), or some kind of memorable detail of his biography (Hipponicus the “Ammon” in Athens at the turn of the 6th and 5th centuries BC).

Another interesting thing took place in pre-Hellenistic times. Nicknames were more often connected not with politicians and state figures but with people from cultural spheres—poets, philosophers.
3-Propynyl-2-substituted Carboxylic Acid Derivatives of Quinazolinone
Authors: USIFOH C. O.
Published: May 2019

Alkylation of quinazolinone-2-carboxylic acids with propargyl bromide in dimethylformamide in the presence of potassium carbonate afforded 3-prop-2-ynyl quinazolinone-2-substituted carboxylic acid derivatives. Further reaction of 4b-c produced 5b-c, which indicates that N-alkylation occurs before esterification with a propynyl moiety.
DENSITOMETRTSCHE UNTERSUCHUNGEN ZUR PHOTOSTABILITÄT VON MELOXICAM
Authors: Bartsch H. , Eiper A. , Göls B. , Kopelent-Frank H.
Published: May 2019

Photodegradation of meloxicam is studied placing special emphasis on the investigation of the correlation between the sample concentration and the stability. For quantitation a HPTLC assay was developed. The stability indicating capability ofthe assay is proved using a sampie solution exposed to artificial irradiation from a xenon source, the peak of meloxicam was weil separated from alldegradation products. For quantitation external calibration is employed. Sample solutions of meloxicam of three different concentrations (2 mg ml-1; 250 μg ml-1 ; 40 μg ml-1) are subjected to simulated sunlight and tested for stability.
Flavonoid Glycosides from Achillea roseo-albax
Authors: Kasaj Denata , Krenn Liselotte , Gschnell Christina , Kopp Brigitte
Published: May 2019

In the first detailed study of the flavonoid pattern of Achillea roseo-alba rutin, apigenin-7-O-ß-glucopyranoside, luteolin-7-O-ß-glucopyranoside, isorhamnetin-3-O-rutinoside, schaftoside, luteolin-4’-O-ß-glucopyranoside and 6-OH-luteolin-7-O-ß-glucopyranosid were proven in the methanolic extract of aerial parts of the plant. Additionally quercetin-3-O-[ß-apiofiranosyl-(1′′′→2′′)-ß-glucopyranoside] was identified for the first time in the genus Achillea.
STEROIDAL SAPONINS FROM SOLANUM UNGUICULATUM (A.) RICH
Authors: Abbas Fawkeya
Published: May 2019

Seven steroidal saponins were isolated for the first time from the green berries of Solanum unguiculatum. Their structures were determined by spectroscopic analysis as well as hydrolysis of the glycosides into the corresponding sapogenins, diosgenin, chlorogenin, diosgenin-3-O-β-D-galactopyranoside, diosgenin-3-O-β-D-glucopyranosyl-(1 → 4)-β-D-galactopyranoside, 3β-hydroxyl-(25R) 5 α-spirostan-6-one (laxogenin) 3-O-α-L-rhamnopyranosyl-(1 → 2)-β-D-glucopyranoside, isonarthogenin-3-O-α-L-rhamnopyranosyl-(1 → 2)-O-[α-L-rhamnopyranosyl-(1 → 4)-β-D-glucopyranoside and 25(S) spirost-5-en-3 β, 17 α, 27 triol-3-O-[α-L-rhamnopyranosyl-(1 → 2)] [α-L-rhamnopyranosyl (1 → 4)]-β-D-glucopyranoside.
Investigation of certain varieties of carbopol in ketorolac tromethamine hydrophilic matrix tablet formulations and evaluation of the kinetics of its in vitm release
Authors: Lütfi Genç , Nahed Hegazy , Betül Arica
Published: May 2019

Matrix tablets of ketorolac trometharnine (KT) were prepared by direct compression technique and Carbopol 934, 940 and 1342 have been used as polymers in different concentrations (5-15 % ). For the quality control of tablets; physical tests as crushing strength, diameter-height ratio and fkiability, KT amount assay and in vitro dissolution techniques were performed and dissolution profiles were plotted and evaluated kinetically. The in vitro release kinetics of ten different formulations of KT matrix tablet were studied at pH 1.2 and pH 7.0 using the USP dissolution technique and apparatus with basket assembly. Dissolution results were evaluated kinetically and statistically. According to our results, different types and concentrations of carbopol to tablet formulations may effect in controlled drug release.
Influence of different solid-dispersion techniques upon the release of dimenhydrinate from chewing-gum formulations
Authors: Jaleh Varshosaz , Jabber Emami , Shirin Hasherni
Published: May 2019

Solid dispersions and physical mixtures of dimenhydrinate (I) in polyethylene glycol 6000 (PEG 6000) and urea were prepared by co-evaporation (or solvent) and fusion-solvent method to increase its aqueous solubility. In contrast to the very slow dissolution rate of pure (I), the dispersion of the drug in the polymers considerably enhanced the dissolution rate. Drug-polymer interactions in the solid state were investigated by differential scanning calorimetry (DSC) and infrared (IR) spectroscopy. By these physical determinations no drug-polymer interactions were evidenced. Finally the solid-dispersions were used in the chewing gum formulations to improve the poor solubility of pure (I) in saliva during mastication. The aqueous dissolution of (I) in chewing gums was favored by the presence of urea. The addition of TweenF' 80 as the solubilizing agent to the chewing gum, increased the release of (I) about 20%, whereas it only increased the solubility of pure (I) by 3%. Drug release profiles from the chewing gum formulations were compared with TravvellQ Gum as the reference standard. The formulation based on solid-dispersion of (I) with urea and Tween 80 released about 60% of the drug after 60 min with a Higuchi kinetic model.
Utility of Certain π-Acceptors for the Spectrophotometric Determination of Hydralazine Hydrochloride
Authors: El-Hawary W. , Shoukry A. , Talat A.
Published: May 2019

The interaction of hydralazine hydrochloride with picric acid (I), 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) (II), 2,4-dinitrobenzoic acid (III), bromanil (IV) and chloranil (V) was found to be useful for its spectrophotometric determination. The determination was carried out at 520, 510, 550, 540 and 535 nm for the reaction with (I), (II), (III), (IV) and (V), respectively. The effect of several variables on the colouring process was studied. The proposed methods have been applied successfully for the determination of hydralazine hydrochloride in pure samples and in pharmaceutical preparations with good accuracy and precision. The results were compared to those obtained by the official and pharmacopoeia1 methods. The linear ranges for obedience of Beer's law are up to 118, 54,639, 27.5 and 78.6 mg/l, Ringbom ranges are 13-100, 7.6-44.7, 77.4-445.0, 5.8-25.8 and 22.5-63.1 μg/ml, Detection limits are 4.8, 2.2, 18.4, 1.2 and 5.9 mg/l, and RSD 0.042, 0.037, 0.043, 0.013 and 0.073 for reactions of hydralazine hydrochloride with I, II, III, IV and V, respectively.
High Performance Liquid Chromatoqraphic Method for the Simultaneous Determination of Labetalol and Hydrochlorothiazide in Tablets and Spiked Human Plasma
Authors: Sultan M. , Abdine H. , Zoman N. , Belal F.
Published: May 2019

A reversed-phase HPLC method with spectrophotometric detection was developed for the simultaneous determination of labetalol (LBT) and hydrochloro-thiazide (HCD). The chromatographic separation was performed using a Microbondapak C18 column (4.6 i.d. x 250 nm) and paracetamol as internal standard. A mobile phase consisting of 0.05 M phosphate buffer/acetonitrile of pH 4 (7:3) at a flow rate of 0.7 ml/min was used. The detection was affected spectrophotornetrically at 302 nm. The working concentration range was 0.3–10 µg/ml with detection limits of 0.05 µg/ml for both drugs. The lower quantitation limit was 0.25 µg/ml in the two cases. The method was successfully applied to tablets, the % recoveries were 99.45 ± 0.68 for LBT and 99.79 ± 0.75 for HCD. The method was extended to the in-vitro determination in spiked human plasma. The % recoveries were 91.12 ± 0.33 for LBT and 91.37 ± 0.40 for HCD. The interday and intraday precision and accuracy were evaluated in plasma by calculating the % RSD (n=5) and the % error and were found to be in the ranges of 1.18–4.1% and 0.38–0.36% for both drugs, respectively.
Ampicillin adsorption by some antacids
Authors: Okor Roland , Fajuyigbe Olanike , Eichie Florence
Published: May 2019

In certain situations of peptic ulcers ampicillin has been co-administered with bismuth carbonate with an implication for adsorption of the ampicillin. To quantify this effect the kinetics and extent of adsorption of ampicillin by some commonly used antacids were measured; these are bismuth carbonate, magnesium trisilicate and aluminium hydroxide. The adsorption of ampicillin by bismuth carbonate followed the Langmuir adsorption isotherm, which suggests chemisorptions. It was characterized by a strong adsorption at a low adsorbate (ampicillin) concentration but the % adsorption decreased with increase in adsorbate concentration, which is a feature of a saturated monolayer adsorption. On the other hand, the adsorption by magnesium trisilicate and aluminium hydroxide followed the Freundlich adsorption isotherm characterized by a low adsorption at a low adsobate concentration but this increased slightly with increase in adsorbate concentration, suggesting a weak physical adsorption. The adsorption capacities (mg/g) of the adsorbate were 1.64 (bismuth carbonate) 0.04 (magnesium carbonate) and 0.03 (aluminium hydroxide). Bismuth carbonate thus gave by far the highest degree of adsorption. The conclusion is that the co-administration of ampicillin and bismuth carbonate in the treatment of certain peptic ulcers is erroneous.
Spectroscopy of NGC 4258 Globular Cluster Candidates: Membership Confirmation and Kinematics
Authors: González-Lópezlira Rosa A. , Mayya Y. D. , Loinard Laurent , Álamo-Martínez Karla , Heald George , Georgiev Iskren Y. , Órdenes-Briceño Yasna , Lançon Ariane , Lara-López Maritza A. , Lomelí-Núñez Luis , Bruzual Gustavo , Puzia Thomas H.
Published: May 2019

We present multiobject spectroscopic observations of 23 globular cluster candidates (GCCs) in the prototypical megamaser galaxy NGC 4258, carried out with the Optical System for Imaging and low-Intermediate-Resolution Integrated Spectroscopy instrument at the 10.4 m Gran Telescopio Canarias. The candidates have been selected based on the (u* − i′) versus (i′ − K

s
) diagram, in the first application of the u*i′K

s
method to a spiral galaxy. In the spectroscopy presented here, 70% of the candidates are confirmed as globular clusters (GCs). Our results validate the efficiency of the u*i′K

s
method in the sparser GC systems of spirals, and given the downward correction to the total number of GCs, the agreement of the galaxy with the correlations between black hole mass and the total number and mass of GCs is actually improved. We find that the GCs, mostly metal-poor, corotate with the H i disk, even at large galactocentric distances.
The Evolution of the Quenching of Star Formation in Cluster Galaxies since z ∼ 1
Authors: Pintos-Castro I. , Yee H. K. C. , Muzzin A. , Old L. , Wilson G.
Published: May 2019

We study the star-forming (SF) population of galaxies within a sample of 209 IR-selected galaxy clusters at 0.3 ≤ z ≤ 1.1 in the ELAIS-N1 and XMM-LSS fields, exploiting the first HSC-SSP data release. The large area and depth of these data allow us to analyze the dependence of the SF fraction, f
SF, on stellar mass and environment separately. Using R/R
200 to trace environment, we observe a decrease in f
SF from the field toward the cluster core, which strongly depends on stellar mass and redshift. The data show an accelerated growth of the quiescent population within the cluster environment: the f
SF versus stellar mass relation of the cluster core (R/R
200 ≤ 0.4) is always below that of the field (4 ≤ R/R
200 < 6). Finally, we find that environmental and mass quenching efficiencies depend on galaxy stellar mass and distance to the center of the cluster, demonstrating that the two effects are not separable in the cluster environment. We suggest that the increase of the mass quenching efficiency in the cluster core may emerge from an initial population of galaxies formed “in situ.” The dependence of the environmental quenching efficiency on stellar mass favors models in which galaxies exhaust their reservoir of gas through star formation and outflows, after new gas supply is truncated when galaxies enter the cluster.
Characterization of uropathogenic ESBL-producing Escherichia coli isolated from hospitalized patients in western Algeria
Authors: Zenati Fatima , Barguigua Abouddihaj , Nayme Kaotar , Benbelaïd Fethi , Khadir Abdelmounaïm , Bellahsene Chafika , Bendahou Mourad , Hafida Hassaïne , Timinouni Mohammed
Published: May 2019

Introduction: The aim of this study is to assess the prevalence and molecular characterization of uropathogenic Extended spectrum β-lactamases (ESBLs) producing Escherichia coli.

Methodology: During 3 years, all hospitalized patients at the University-affiliated hospital of Tlemcen and presenting urinary tract infections caused by E. coli were considered as potential study participants. These E. coli isolates were examined phenotypically for ESBL production. ESBL strains were subjected to antimicrobial susceptibility testing and were investigated for the presence of plasmid mediated quinolone resistance genes, 16SrRNA methylase genes and virulence genes by using conventional PCR and DNA sequencing. The molecular characterization of ESBL strains was established by phylogenetic grouping method and ERIC-PCR.

Results: The overall prevalence of ESBL was 32.5%. The blaCTX-M-15 was the most frequently detected in ESBL isolates, followed by blaCTX-M-14, blaCTX-M-28, blaCTX-M-1 and blaSHV-12 respectively. The plasmid-mediated quinolone resistance genes were detected in the 15 ESBL strains with the aac(6’)-Ib-cr gene was the most detected followed by qnrB1 and qnrA1 gene respectively. Among the 22 ESBL isolates resistant to gentamicin and amikacin, the 16SrRNA methylase genes were detected in 4 isolates. The sfa and pap virulent genes were founds in 26% and 22% of isolates receptively. The genotyping analysis of all strains revealed that almost were belonged to phylogenetic groups A1 and A0 and fourteen distinct clones.

Conclusion: The emergence of uropathogenic ESBL isolates and the high rate of blaCTX-M are alarming in Algeria. Strict measure must be required to control the further spread of these strains in Algerian hospitals.
Endocan - a potential diagnostic marker for early onset sepsis in neonates
Authors: Zonda Gabriela Ildiko , Zonda Radu , Cernomaz Andrei Tudor , Paduraru Luminita , Avasiloaiei Andreea Luciana , Grigoriu Bogdan Dragos
Published: May 2019

Introduction: Neonatal early onset sepsis assessment is based on the history of pregnancy and delivery and nonspecific clinical signs. None of the biomarkers currently in use for clinical practice has adequate prognostic value, so it is not possible to clearly distinguish neonates with culture-proven sepsis from those with only risk factors or clinical suspicion. Endocan is an endothelial mediator involved in the inflammatory response that is present in low concentrations in the serum of healthy subjects, and in much higher concentrations in patients with SIRS and septic shock. The purpose of this study is to evaluate the utility of serum endocan serum levels as a biomarker for the diagnosis of neonatal early onset sepsis (EOS).
Methodology: Serum endocan concentration was measured in newborns with clinical suspicion of EOS admitted to the Neonatal Intensive Care Unit on day 1, 3 and 7.
Results: Serum endocan levels were significantly increased in septic compared to non-septic neonates in the early stages of sepsis (2.43 ± 0.95 vs. 1.77 ± 0.57, p = 0.004), continued to rise up to 72 hours from onset and then decreased by the seventh day under treatment.
Conclusions: These results suggest a potential role for endocan as an early marker for diagnosis and follow-up in neonatal EOS. Studies on a larger number of cases are needed in order to establish the practical utility of this molecule as a diagnostic tool for clinical practice.
Farinha de trigo enriquecida com pó de Pleurotus sajor-caju
Authors: Lima Styfanie Gonçalves de , Souza Nicole Fernanda , Duprat Mariana Falcão Leal Brotero , Gern Regina Maria Miranda , Furlan Sandra Aparecida , Wisbeck Elisabeth
Published: May 2019

Informações a respeito da composição de alimentos têm se tornado cada vez mais importantes para avaliar a sua qualidade, constituintes como proteínas, lipídeos, minerais e fibras são relevante para profissionais das áreas da saúde e de alimentos. A farinha de trigo é o principal ingrediente de muitos alimentos básicos da dieta humana, tais como pães, biscoitos e massas. Cogumelos do gênero Pleurotus representam um alimento com alto teor de proteínas de boa qualidade, fibras, diversas vitaminas e minerais, além de baixos teores de gorduras. Assim, o objetivo do trabalho foi avaliar a utilização de Pleurotus sajor-caju em pó como enriquecedor alimentar da farinha de trigo com o intuito de aumentar seu valor nutricional. A farinha de trigo enriquecida com 20% de pó de P. sajor-caju pode ser considerada um alimento que não contém sódio, tem baixo teor de gordura, alto teor de proteínas e vitamina B1 e ainda é fonte de fibras alimentares, fósforo, potássio, ferro e vitamina B2. Os resultados físico-químicos (umidade, cor, cinzas, glúten úmido e número de queda) mostraram que a adição de 20% de P. sajor-caju na farinha de trigo não promoveu mudanças drásticas nestas características. Já as análises de alveografia e farinografia na farinha enriquecida mostraram alterações significativas para a panificação. No entanto, os resultados obtidos na análise sensorial do pão feito com farinha enriquecida com de 20% de P. sajor-caju (pão de cogumelo) indicaram que todos os atributos avaliados (aparência, textura, cor, aroma, sabor e aceitação global) apresentaram índice de aceitabilidade maior que 70%.
Efficiency of extraction of antioxidant compounds in by-product from red guava processing
Authors: Oliveira Silva Maira , Pastore Gláucia Maria
Published: May 2019

Studies that investigate efficient methods for extraction of antioxidant compounds in by-products of fruits can contribute to their appreciation in human food. This study aimed comparing two methods for phenolic extraction - single extraction (single solvent) and sequential (different solvents) in by-product from Paluma guava processing, evaluating the influence of the extracts on the stabilization of radicals by DPPH and ORAC assays. Sequential extraction showed higher efficiency in obtaining phenolic (2.60 > 0.56 mg GAE g-1), allowing the extraction of free phenolic, conjugated and fat-soluble, as well as determining the   highest antioxidant capacity in these extracts. Acetone was characterized to be the responsible solvent for higher extraction of phenolic in the sequential extraction, being necessary 0.90 mg mL-1 of extract to reduce 50% the action of DPPH• radicals. Thus, sequential extraction of phenolic is a potential method for better use of antioxidant compounds in the guava processing by-product.