bluuebunny/crossref_metadata_2025 huggingface dataset:
Functional Gene and Metabolic Changes of Marine Microbial Populations Involved in Hydrocarbon Degradation Under Different Enrichment Conditions
Authors: Song Bingkui , Zhang Zhongzhen , Li Si , Fu Qitong , Qi Shuting , Li Liang , Mu Di , Zhang Aili
Published: April 2021

In this study, seawater from the area of an oil extraction platform in Bohai Bay was subjected to experimental treatments with oil as the only carbon source to understand the transcriptional responses of seawater microbial populations to oil degradation treatments. Twelve enrichment conditions were used, and fluorescent in situ hybridization (FISH) along with metatranscriptomic analyses were used to understand functional changes within each treatment. RNA from the petroleum-degrading bacterial enrichments was extracted after cultivation and FISH was used to evaluate overall activity, while changes in gene expression among different culture conditions were analyzed based on eight hydrocarbon-specific gene probes and flow cytometry. Concomitantly, 1,066 metabolic pathways were identified as being expressed in the populations through RNA sequencing, metatranscriptomic analysis, and metabolic pathway enrichment analysis. The addition of oil led to the inhibition of carbohydrate metabolism and inositol phosphate metabolism, while also reducing extracellular signaling pathway transcription levels. When low- and high-nutrient conditions were compared, low-nutrient conditions inhibited taurine and hypotaurine metabolism in addition to inositol phosphate metabolism. Among oxygen-treated, carbon dioxide-treated, and air-treated conditions, oxygen-treated conditions inhibited taurine and hypotaurine metabolism but promoted galactose metabolism, while carbon dioxide-treated conditions promoted inositol phosphate metabolism. Overall, metabolic pathway expression and functional gene changes indicated that high-nutrient, oil-free, and aerobic culture conditions best promoted the growth and reproduction of marine microbial communities.
Peanut Components Measured by ISAC: Comparison With ImmunoCap and Clinical Relevance in Peanut Allergic Children
Authors: Brand Kim , Schreurs Marco , Emons Joyce , Wijk Roy Gerth van , de Groot Hans , Arends Nicolette
Published: April 2021

BackgroundSpecific IgE (sIgE) against the peanut component Arachis hypogaea (Ara h) 2 has been shown to be the most important allergen to discriminate between peanut allergy and peanut tolerance. Several studies determined sIgE cut off values for Ara h 2, determined by singleplex measurements. However, cut off values for Ara h 2 from multiplex arrays are less well defined. The aim of this study was to evaluate the correlation between Ara h 2 sIgE determined by singleplex versus multiplex measurements and to assess the diagnostic value of the different peanut components included in Immuno Solid-phase Allergen Chip (ISAC) multiplex analysis in children with a suspected peanut allergy.Methods In this retrospective study we analyzed Ara h 2 sIgE values with singleplex Fluorescence Enzyme Immunoassay (FEIA, ImmunoCap) and multiplex microarray (ISAC) measurements in 117 children with a suspected peanut allergy. Also, other peanut components measured by ISAC were analyzed. Double blinded placebo controlled oral food challenges were used as golden standard.Results Among all studied peanut components FEIA Ara h 2 sIgE showed the highest area under the curve (AUC, 0.922), followed by ISAC Ara h 6 and Ara h 2 sIgE with AUCs of respectively 0,906 and 0,902. Best cut off values to diagnose peanut allergy were 4.40 kU/l for FEIA Ara h 2 sIgE and, 7.43 ISU and 8.13 ISU for respectively Ara h 2 and Ara h 6 sIgE in ISAC microarray. Ara h 2 sIgE determined in FEIA and ISAC showed a good correlation (r=0.88. p<0.01). ConclusionAra h 6 and Ara h 2 sIgE in multiplex ISAC are both good predictors of clinical peanut allergy, and their performance is comparable to the use of Ara h 2 in singleplex FEIA. The simultaneous measurement of Ara h 6 and Ara h 2 sIgE using ISAC is an advantage and clinically useful to detect peanut allergic children that are monosensitized to Ara h 6.
Phenobarbitone Induced Toxic Epidermal Necrosis in a Young Patient - A Rare Clinical Presentation: A Case Report and Brief Review of the Literatures
Authors: Ayele Biniyam A. , Ali Kemal , Mulatu Eliyas
Published: April 2021

Background: Toxic epidermal necrolysis (TEN)/ Stevens-Johnson syndrome (SJS) is the spectrum of severe, acute, mucocutaneous, Ig E mediated hypersensitivity reaction; universally related to different drugs. Phenobarbitone is known to cause hypersensitivity reactions with benign pattern; ranging from a mild to moderate rashes but not life-threatening reactions such as TEN/SJS. Little is known about TEN in asthmatic patient. To the best of our knowledge, this is the first case of Phenobarbitone-induced TEN in a young asthmatic patient from the sub Saharan African. Case report: We report a 14-year-old right handed asthmatic male patient who presented with extensive blister skin eruptions involving the whole body including mouth ear canal later followed by skin exfoliation associated with low grade fever, sore throat, and dysphagia. The hypersensitivity skin reaction developed two weeks after initiation of Phenobarbitone of 100mg twice daily for a new onset generalized tonic clonic seizure. The exfoliation also involved oral and Conjunctival mucosa; with estimated 65% body surface area involvement; hence the diagnosis of Toxic epidermal necrosis was made. The Laboratory investigations were relevant for mild leucocytosis, prolonged prothrombin time, and reduced albumin. Phenobarbitone was discontinued and replaced with clonazepam; and the patient was managed with fluids replacement, IV antibiotics, twice daily wound care, analgesics, and naso gastric tube feeding. On subsequent days in intensive care unit (ICU), the patients’ clinical condition started improving; the skin lesion also started to heal and exfoliate in most of the affected skin surface areas, and the patient was discharges improved after ten days of ICU care.Conclusion: In summary, the present case describes, a 14-years-old young child with history of allergy in a form of asthma and new onset seizure disorder; and developed toxic epidermal necrosis following exposure to Phenobarbitone. This case also highlighted the benign prognosis observed in paediatrics population with TEN.
Testing Hypotheses About Glacial Dynamics Using a Statistical Model of Paleo-Climate
Authors: Kaufmann Robert , Pretis Felix
Published: April 2021

We test hypotheses about glacial dynamics by evaluating the ability of a linear statistical model to simulate climate during the previous ~800,000 years. During this period, the linear model simulates the timing and magnitude of glacial cycles, including the saw-tooth pattern in which ice accumulates gradually and ablates rapidly, without falsely simulating an interglacial after each peak in obliquity. Conversely, the linear model fails to simulate experimental observations that are created by a nonlinear data generating process. Together, these (in)abilities suggest that nonlinearities, threshold effects, bifurcations, and/or phase-specific governing equations do not play a critical role in glacial cycles during the late Pleistocene. Furthermore, the model’s accuracy throughout the sample period suggests that changes in orbital geometry create the Mid-Brunhes event.
Performance evaluation and analysis of four waves mixing in DWDM optical communications
Authors: Elsayed Ebrahim E.
Published: April 2021

Optical nonlinearities give rise to many ubiquitous effects in optical fibres. These effects are interesting in them and can be detrimental in optical communication. In the Dense Wave length division multiplexing system (DWDM) the nonlinear effects plays important role .DWDM system offers component reliability, system availability and system margin. DWDM system carries different channels. Hence power level carried by fiber increases which generates nonlinear effect such as SPM ,XPM, SRS, SBS and FWM. Four waves mixing (FWM) is one of the most troubling issues. The FWM gives crosstalk in DWDM system whose channel spacing is narrow. Wavelength exchanging enables data swapping between two different wavelengths simultaneously. These phenomena have been used in many applications in Wavelength Division Multiplexing (WDM) optical networks such as, wavelength conversion, wavelength sampling, optical 3R, optical interconnects and optical add-drop multiplexing.
Short Version of the Inventory of Parental Representations for Attachment Assessment Among Adolescents
Authors: Lamourette Marilou , Ligier Fabienne , Guillemin Francis , Epstein Jonathan
Published: April 2021

Background: The Inventory of Parental Representations (IPR), a self-administered questionnaire, was developed primarily to identify styles of attachment in adolescence. However, it did not present stable psychometric properties in the various American studies carried out. The aim of this study was to adapt the IPR in French and to provide a shorter version with improved psychometric properties and a sound content.Methods: The content validity was carried out by an expert committee and 10 adolescents. The study of the metric properties of the French version of the IPR was realized in a sample of 275 responses. In case of mediocre results in the CFA of the existing structures, the development of a new IPR structure was planned (Classical Test Theory and Rasch Modelling).Results: Out of 62 items translated, 13 needed adaptation. The analysis of its metric properties produced mediocre results. In a group of 275 adolescent’s responses, a step-by-step process was implemented. Content and psychometric property analyses generated a paternal Short-IPRF (15 items) and a maternal Short-IPRM (16 items) scale with sound content and good psychometric properties confirmed in an independent sample of 795 responses (Short-IPRF: Comparative Fit Index (CFI)=0.987, Tucker-Lewis Index (TLI)=0.982, Root Mean Square Error of Approximation (RMSEA)=0.027; Short-IPRM: CFI=0.953, TLI=0.927, RMSEA=0.068). Using Rasch modelling, the attachment was correctly measured overall especially for insecure attachment. Conclusions: A step-by-step process involving both content analysis and psychometric property analysis led to the generation of two questionnaires, a paternal scale, the Short-IPRF, and a maternal scale, the Short-IPRM.
Medical Students’ Readiness for Virtual Clerkships During the COVID-19 Pandemic.
Authors: Al-Moslih Ayad , Shami Rula , Al-Jayyousi Ghadir Fakhri , Du Xiangyun , Al-Awaisi Alla , Rahim Hanan Abdul , Diab Mohammad , Bawadi Hiba
Published: April 2021

BackgroundThis study aims to qualitatively examine the readiness of medical students to change to virtual clerkship during the pandemic, from both the faculty preceptors and students’ perspectives’. MethodsA qualitative study was conducted based on the framework of readiness to change. Focus group discussions with students, and semi-structured interviews with clinical faculty members were done using appropriate online platforms. Transcripts were then analyzed using a qualitative phenomenological approach.Results Twelve themes emerged which are 1) Perceptions about the university decision and its communication to students, 2) A Perceived Lack of clinical experience, 3) Student safety , 4) Students’ role as members of the medical team facing the pandemic, 5) Quality and design of VI and the skills it offered, 6) Belief in own ability to succeed in the VC, 7) Confidence that VC would reach its goals, 8) New enhanced learning approaches, 9) Acquired skills, 10) Preparing students for new types of practice in the future, 11) Academic support and communication with faculty and college, 12) Psychological support. Medical students showed limited readiness to undertake a virtual clerkship and not play their role as healthcare professionals during the pandemic. They perceived a huge gap in gaining clinical skills virtually and asked for quick return to training sites.ConclusionsMedical students were not ready for virtual clerkships. There will be a need to integrate novel learning modalities such as patient simulations and case-based learning in order to meet future demands of the medical profession and enhance the efficiency of virtual clerkships.
Effect of acupuncture for diminished ovarian reserve: study protocol for a randomized controlled trial
Authors: Xu Huanfang , Hao Mingzhao , Zheng Chensi , Yang Huisheng , Yin Yaqian , Yang Li , Fang Yigong
Published: April 2021

Background: Diminished ovarian reserve (DOR) is described as reduced fecundity. A satisfactory treatment is lacking despite the upward trend of the prevalence. Acupuncture has been reported as an alternative therapy for female infertility. The purpose of this study is to investigate the effect of acupuncture for women with DOR.Methods/Design: In this randomized controlled trial, a total of 120 women with DOR will be randomized to receive either acupuncture or sham acupuncture for 12 weeks. The primary outcome is the antral follicle counting (AFC).Discussion:This study is expect to investigate the effect of acupuncture versus superficial needling in improving ovarian reserve for women with DOR.Trial registration:Acupuncture-Moxibustion Clinical Trial Registry (ChiCTR1800014988).
Properties of the Transfers from LEO to the Retrograde-GEO using Lunar Swing-by in a Three-Body Model
Authors: He Boyong , Ma Pengbin , Li Hengnian
Published: April 2021

A monitor-satellite on a retrograde geostationary earth orbit (retro-GEO) gives the GEO-assets debris-warnings per 12 hour. The properties of the transfers from a low earth orbit to the retro-GEO using lunar swing-by without middle-way maneuver are exhibited in a three-body model. Based on the Poincaré-section methodology, the proof of the existence of this transfer is proven in the planar circular restricted three-body problem (CR3BP) model. Then, the maximum altitude of the perilune of this transfer is solved using the sequence quadratic programming optimization algorithm. Besides, the orbital inclination changeable capacity of this transfer is calculated in the spatial CR3BP model by the continuation of the orbital design values in the planar CR3BP model. The numerical results show that the maximum altitude of the perilune is 892 km and the maximum orbital inclination changeable capacity is 138 degree relative to the plane of the Moon’s path. Further analysis show that the minimum sum of the two-impulse velocity increments (i.e., departure from LEO and insert into the retro-GEO) is 4.224 km/s, the change of the orbital inclination is 107 degree relative to the plane of the Moon’s path in this case. Due to the maximum angle of the plane of the Moon’s path on the equator is 28.6 degree per Metonic cycle (i.e., 18.6 years), everyday has a month window to match the longitude of the launch-site for trans-lunar injection.
A case study of the application of WEKA software to solve the problem of liver inflamation
Authors: Vujović Željko
Published: April 2021

The aim of this paper was to consider the reliability of the basic metrics of evaluation of classification models: accuracy, sensitivity, specificity and precision. The WEKA software tool was applied to the "Hepatitis C virus (HCV) for Egyptian patients dataset". The algorithms Bayesnet, Naivebayesh, Multilayer Perceptron, J48 and 10-fold cross validation were used in the study. The main results obtained are that, with all four algorithms in question, they achieved approximately the same accuracy of correctly classified specimens. BaiesNet - 22.96%, NaiveBaies - 26.14%, MultilaierPerceptron - 26.57% and J48 - 25.27%. Binary classification metrics - sensitivity, specificity and precision show very different values, depending on the intended class. Metric specificity, for all four algorithms, shows that a value that is in most of the range of possible values ​​[0,1]. Metric sensitivity and precision, for all four algorithms, showed values ​​that are in the lower part of the range of possible values ​​[0,1]. The results of this study showed that WEKA software could not yet be considered as a relevant tool for the diagnosis of Hepatitis C Virus, on whose data set it was applied.
Neuromorphic processing at Tera-OP/s speeds with soliton crystal microcombs
Authors: Tan Mengxi , Xu Xingyuan , Moss David
Published: April 2021

Convolutional neural networks (CNNs), inspired by biological visual cortex systems, are a powerful category of artificial neural networks that can extract the hierarchical features of raw data to greatly reduce the network parametric complexity and enhance the predicting accuracy. They are of significant interest for machine learning tasks such as computer vision, speech recognition, playing board games and medical diagnosis [1-7]. Optical neural networks offer the promise of dramatically accelerating computing speed to overcome the inherent bandwidth bottleneck of electronics. Here, we demonstrate a universal optical vector convolutional accelerator operating beyond 10 Tera-OPS (TOPS - operations per second), generating convolutions of images of 250,000 pixels with 8-bit resolution for 10 kernels simultaneously — enough for facial image recognition. We then use the same hardware to sequentially form a deep optical CNN with ten output neurons, achieving successful recognition of full 10 digits with 900 pixel handwritten digit images with 88% accuracy. Our results are based on simultaneously interleaving temporal, wavelength and spatial dimensions enabled by an integrated microcomb source. This approach is scalable and trainable to much more complex networks for demanding applications such as unmanned vehicle and real-time video recognition.
Polyphosphate (PolyP) for alveolar cleft repair, study protocol for a pilot randomized controlled trial.
Authors: Alkaabi Salem , Kalla Diandra S Natsir , Fauzi Abul , Tajrin Andi , Müller WEG , Schröder HC , Wang XH , Forouzanfar Tim , Helder MN , Ruslin M , Alsabri Ghamdan
Published: April 2021

Objective: Bone grafting is an important surgical procedure to restore missing bone in patients with alveolar cleft lip/palate, aiming to stabilize either sides of maxillary segments by inducing new bone formation, and in bilateral cleft cases also to stabilize the pre- maxilla. Polyphosphate (PolyP), a physiological polymer composed of orthophosphate units linked together with high-energy phosphate bonds, is a naturally existing compound in platelets which, when complexed with calcium as Ca-polyP microparticles (Ca-polyP MPs), was proven to have osteoinductive properties in preclinical studies. Aim: To evaluate the feasibility, safety and osteoinductivity of Ca-polyP MPs as a bone-inducing graft material in humans. Methods: This prospective non-blinded first-in-man clinical pilot study shall consist of 8 alveolar cleft patients of 13 years or older to evaluate the feasibility and safety of Ca-PolyP MPs as a bone-inducing graft material. Patients will receive Ca-polyP graft material only, or Ca-polyP in combination with biphasic calcium phosphate (BCP) as a bone substitute carrier. During the trial, the participants will be investigated closely for safety parameters using radiographic imaging, regular blood tests, and physical examinations. After 6 months, a hollow drill will be used to prepare the implantation site to obtain a biopsy. The radiographic imaging will be used for clinical evaluation; the biopsy will be processed for histological/histomorphometric evaluation of bone formation. Discussion: This is the first-in-man study evaluating the safety and feasibilty of the polyP as well as the potential regenerative capacity of polyP using an alveolar cleft model.Trial registration {31a} The clinical trial protocol received a written approval by the ethical committee of Faculty of Medicine, Hasanuddin University, Makassar, Indonesia with code number 1063/UN4.6.4.5.31/PP36/2019. On completion of the trial, the results on safety, feasibility and bone formation with polyP as graft material will published.
FEATURES OF FORMATION AND APPLICATION OF FINANCIAL MONITORING SYSTEM IN UKRAINE
Authors: Rekunenko I. , Kobets Zh. , Shvydko I.
Published: April 2021

The article is devoted to the study of peculiarities of formation and development of the national system of financial monitoring in the context of Preventing and Combining the Money Legalization (Laundering) and / or Terrorism Financing (AML / CFT). The basic approaches to the definition of the essence of the concept of «financial monitoring» are systematized according to the level of its conduct, and legal aspects of AML / CFT regulation in Ukraine are disclosed. The main functions of financial monitoring, including organizational and managerial, control and supervision, operational-analytical, informative and preventative are identified. The results of the activity of the State Financial Monitoring Service of Ukraine are reviewed, which confirm that the banking sector is the most financially powerful channel of illegal flows. In turn, financial monitoring of the non-banking sector is characterized by low institutional performance. The article provides a list of financial transactions that are most commonly associated with the illicit legalization of income, including cash transactions and transactions related to obtaining or providing financial assistance. It is determined that the key problems of establishing a system of financial monitoring in Ukraine are: contradictory conditions of state-building processes (weakness of law enforcement and judicial authorities); imbalance of regulation of business activity (complexity and duration of starting a business, high level of tax burden); peculiarities of investment policy; low level of financial inclusion in Ukraine. Given the international experience of developed countries, it is advisable to expand the list of financial crimes related to AML / CFT in accordance with the FATF Recommendations; strengthen interagency coordination and create a unified information exchange system; reinforce the personal responsibility of officials. The main directions of realization of the concept of development of the financial monitoring system in Ukraine should be: intensification of international cooperation; improvement of mechanisms for identification and disclosure of suspicious transactions, elimination of «blind zones» or disorderly allocation of competences; In addition, the main task of conducting internal financial monitoring at the bank level should be use the tools «customer due diligence / enhanced due diligence», as well as «know you client / know your customer's customer», in order to ensure transparency (legality) of relationships with counterparties.
ASSESSMENT OF DEMAND FOR PUBLIC GOODS IN THE NON-MARKET SERVICES SECTOR
Authors: Petrushenko Yu. , Mayboroda T. , Onopriyenko K.
Published: April 2021

The article is devoted to the development and approbation of approaches to the assessment of demand for public goods. It presents the results of the assessment of demand for civic education as a public good of the nonmarket services sector. The assessment is based on the application of various research methods: desk research (analysis of publications, reviews, reports), qualitative research (focus groups, in-depth interviews), quantitative research (sociological survey). In this article is carried out the analysis of scientific publications devoted to the analysis of demand for public goods, and the actual aspects of researches are allocated. The object of research is the process of forming and meeting the demand for civic education. For analysis of the market of educational needs was conducted a comparison of the population's requests for educational services and data of the number of activities carried out by providers of educational services. The result of research is the proof of hypotheses about low demand for civic education in the conditions of absence of high level of civic competence and in the conditions of mismatch of supply and demand in the field of civic education. Regarding various areas of civic education, the results of the analysis showed that the greatest demand is in creative studios, and this demand is quite satisfied. Next in the ranking are educational services in the field of leadership and personal development, but these needs are satisfied with less than half. The rest of the needs are unmet, and at the same time we see that due to the actions of service providers, the interest of citizens in political or civic education is approaching to satisfaction level. At the same time, low satisfaction of the needs in financial literacy, critical thinking, and media literacy indicates the necessity to develop and offer educational services of this type. Demand for family psychology, relationship psychology, public speaking and business education is also unmet. The conclusions of the study formulate proposals for matching demand and supply for civic education through non-market mechanisms. In particular, it is justified the need for the formation of effective demand from local authorities and local public institutions (local schools, universities, businesses, NGOs).
DEVELOPMENT OF THE BASIC LEVEL OF THE FINANCIAL SYSTEM OF UKRAINE IN THE GLOBALIZATION CONDITIONS
Authors: Boronos V. , Riabushka L. , Vidmenko Y.
Published: April 2021

The article deals with the theoretical and practical aspects of the development of economic entities as the basic equal state systems of Ukraine in the context of their global ones. This paper examines the impact of global internationalization of business relations on national activity. The stages of enterprise development in the conditions of globalization transformations are determined and the essence of the concept of "enterprise development" is interpreted. The state of development of business entities by quantitative and qualitative indicators is analyzed. In particular, a numerical assessment of the existing composition of business entities and their dynamics are revealed. Indicators of sales volumes of manufactured products in the context of legal and physical business structures are considered. A vertical analysis of sales of products by type of economic activity in terms of forms of organization. Concentration of the prevailing volume of sales in the hands of enterprises testifies to their strategic importance in the processes of globalization of the Ukrainian economy. The tendency of formation of net financial result by Ukrainian enterprises is presented. The main purpose of functioning of the enterprise in the conditions of globalization is to gain competitive positions, which is a characteristic of the internationalized market. The impact of globalization, as a driving factor in the development of economic entities, is transcending them beyond national borders. Within this framework, the influence of multinational corporations on the level of increasing the functional capacity of domestic business entities is identified. Competing with TNCs and having an imperative presence in the global market, business entities need to take into account the characteristics of both significant and large-scale markets and local (regional) consumer cultures. Globalization trends are forcing manufacturing companies to expand their markets and fully meet the individual needs of consumers. In the context of globalization, the factors that negatively affect the state of development of economic entities have been identified, in particular, modern factors of influence on the structural elements of the financial system of Ukraine have been identified.
ECOLOGICAL AND ECONOMIC ASSESSMENT OF THE CONSEQUENCES OF THE USE OF RENEWABLE ENERGY SOURCES
Authors: Pavlyk A. , Zhulavskyi A. , Shkodkina Iu. , Maslii M.
Published: April 2021

The article is devoted to the problem of an environmental-economic assessment of consequences of using renewable energy sources. The existing system for assessing environmental-economic consequences of energy production can be applied only to traditional energy sources — combined heat and power plants (CHP plants), thermal power plants (TPP), and atomic power plants, since it is unviable to apply it for renewable energy sources. The reason lies in the peculiar features of renewable energy sources — they do not use exhaustible energy resources for the purpose of energy generation and have a small minimum size of a power station, which makes renewable energy sources more mobile and available for the use in the private sector of economy. This article proposes a methodology of an environmental-economic assessment of the consequences of energy generation from renewable energy sources, which takes into account the features of renewable energy sources use in comparison to traditional ones. In this paper, we analyze shortcomings of the existing methodology for assessing consequences of harmful substances emissions into the atmosphere and propose our own methodology. It includes a life cycle theory of an energy product, which allows to identify environmental-economic consequences at every stage of the life cycle of an energy product and to assess them. For an objective assessment we used statistical data and existing calculations from domestic scientists on a correlation between the number of diseases and volume of harmful substances emissions into the atmosphere. The methodology allows to assess and compare environmental-economic consequences of the development of a particular energy source in relation to other sources. Despite the generally accepted opinion that there are no environmental and economic consequences of the use of renewable energy sources, this paper proves that renewable energy sources have such an impact at different stages of their life cycle. Research findings and calculations in this paper allow to use existing mathematical tools to develop optimal models for the energy sector development of Ukraine. The proposed methodology can be applied to other countries in order to identify its shortcomings and develop further this methodology of assessment.
Psychometric properties of the Inventory of Interpersonal Problems (IIP-C) used with a clinical sample of adolescents: a preliminary study
Authors: Israel Pravin , Langeveld Johannes Hendrik
Published: April 2021

Background:

Interpersonal problems are consistently identified with psychopathology that often has its onset in adolescence. Most of the commonly used instruments in child and adolescent psychiatry target non-interpersonal problems. The Inventory of Interpersonal Problems (IIP) is a widely studied and utilized instrument in the adult mental health field.

Aims:

This study aimed to examine the psychometric properties of the IIP (circumplex version) used with a clinical adolescent population. Method: Sixty-two adolescents (13-17 years) who received treatment in a child and adolescent mental health clinic (CAMHS) were included in the study. To establish reliability and validity, we conducted confirmatory factor analyses, internal consistency, and validity analyses.

Results:

Confirmatory analyses did not show optimal model fit. However, other indices like CFI and TLI were promising. The reliability of the eight scales was in the same range as previous studies and acceptable. There were expected significant correlations between IIP-C scales and the broadband scales of Youth Self-report (YSR).

Conclusion:

The pioneer nature and its clinical focus are strengths however, there is a need for more research. The promising results are encouraging, and future research could also explore how best to bring the instrument into the digital age.
Forecasting and Mapping Coffee Borer Beetle Attacks Using GSTAR-SUR Kriging and GSTARX-SUR Kriging Models
Authors: Pramoedyo Henny , Ashari Arif , Fadliana Alfi
Published: April 2021

The research aimed to use Generalized Space Time Autoregressive (GSTAR) and GSTARX modeling with the Seemingly Unrelated Regression (SUR) approach and combine them with the Kriging interpolation technique in an unobserved location. The case study was coffee borer beetle forecasting in Probolinggo Regency, East Java, Indonesia, with Watupanjang Village as the unobserved location. The results show that GSTAR-SUR Kriging and GSTARX-SUR Kriging models can predict coffee borer beetle attacks in unobserved areas with high accuracy. It is indicated by the Mean Absolute Percentage Error (MAPE) values of less than 10%. The addition of exogenous variables (rainfall) into the model is proven to improve the accuracy of the model. The Root-Mean-Square Error (RMSE) value of the GSTARX-SUR Kriging model is smaller than the GSTAR-SUR Kriging model. The structure of the model produced from the research, GSTARX-SUR (1,[1,12])(10,0,0), can be used as a reference in modeling coffee borer beetle attacks in other regencies. Map of forecasting coffee borer beetle attack shows that the spread of coffee borer beetle attack is spatial clustering with the attack center located in the eastern region of Probolinggo Regency.
Finding Biomarkers from a High-Dimensional Imbalanced Dataset Using the Hybrid Method of Random Undersampling and Lasso
Authors: Rochayani Masithoh Yessi , Sa'adah Umu , Astuti Ani Budi
Published: April 2021

The research conducted undersampling and gene selection as a starting point for cancer classification in gene expression datasets with a high-dimensional and imbalanced class. It investigated whether implementing undersampling before gene selection gave better results than without implementing undersampling. The used undersampling method was Random Undersampling (RUS), and for gene selection, it was Lasso. Then, the selected genes based on theory were validated. To explore the effectiveness of applying RUS before gene selection, the researchers used two gene expression datasets. Both of the datasets consisted of two classes, 1.545 observations and 10.935 genes, but had a different imbalance ratio. The results show that the proposed gene selection methods, namely Lasso and RUS + Lasso, can produce several important biomarkers, and the obtained model has high accuracy. However, the model is complicated since it involves too many genes. It also finds that undersampling is not affected when it is implemented in a less imbalanced class. Meanwhile, when the dataset is highly imbalanced, undersampling can remove a lot of information from the majority class. Nevertheless, the effectiveness of undersampling remains unclear. Simulation studies can be carried out in the next research to investigate when undersampling should be implemented.
Implementation of Microservices Architecture on E-Commerce Web Service
Authors: Suthendra Juan Andrew , Pakereng Magdalena Ariance Ineke
Published: April 2021

The research aimed to make e-commerce web services using a microservices architecture. Web service was built using Representational State Transfer Protocol (REST) with Hypertext Transfer Protocol (HTTP) method and JavaScript Object Notation (JSON) response format. Meanwhile, the microservices architecture was developed using Domain-driven Design (DDD) approach. The research began by analyzing e-commerce business processes and was modeled using Unified Modeling Language (UML) based on business process analysis. Next, the bounded context was used to make a small responsible service for a function. The Programming language used to make the system was Go programming language with Go-kit tool and apply database-per-service pattern for data management. The system also applied the concept of containerization using Docker as the container platform and using API Gateway to manage each endpoint. Last, the evaluation process was carried out using the Postman application by testing each endpoint based on the white-box testing method. Based on the results of the evaluation process, the e-commerce web service can work as expected. The results also show that the system has a high level of resilience. It means that the system has a low level of dependencies between services and adapts to future changes.
PERFORMING RELIABLE ABSORBANCE AND FLUORESCENCE MEASUREMENTS WITH LOW BUDGET – A TUTORIAL FOR BEGINNERS
Authors: Barreto Diandra , Leal Vanderli , Conrado Josiele , Fernandes Gabriel , Machado Caio , Batista Alex , Silva Sidnei , Petruci João
Published: April 2021

Molecular absorbance and fluorescence measurements are usually performed by benchtop or portable USB spectrophotometers or fluorometers. However, even the simplest configuration of these instruments requires considerable financial input, which is not affordable to many universities and research groups especially when public politics withdraw funds from science. Light-emitting diodes (LEDs) based devices can be an interesting alternative for low-cost, portable yet reliable measurements of absorbance of fluorescence. Especially if associated with the fabrication of 3D structures by additive manufacturing techniques. Although there are many reviews in the literature dedicated to discussing the theoretical aspects and analytical performance of LED-based devices, we consider that these reviews are not easily applicable for beginners in electronics. It results in the intimidation to employ such powerful tools which could have a huge impact mainly to small and/or initial groups. In this tutorial, we present a guide that will help students and researchers to construct “lab-built” devices based on simple optoelectronic components and 3D printing to perform molecular absorbance and fluorescence measurements for analytical methods. Finally, with this tutorial guide, we anticipate a large spread of the usage of LED devices for reliable analytical measurements that can be extensively used in many scenarios.
Augmented HLL Riemann solver including slope source term for 1D mixed pipe flows
Authors: Chen Shangzhi , Zheng Feifei , Liu Xin
Published: April 2021

In this paper, the augmented version of finite volume Harten–Lax–van Leer (HLL) solver, including source terms, is extended to free-surface and pressurized mixed pipe flows over complex and frictional topography. This augmented HLL Riemann solver is employed for the flux approximation at the cell interface, where source terms are split into two parts based on the wave propagation speed. The friction term is treated using a splitting implicit method to maintain stability over dry beds. The Preissmann slot method is adopted to reproduce pressurized flow in the conduit. The performances of the numerical model are investigated by several numerical tests and compared with existing methods showing clear improvements.
Citizen deliberation in the context of Uruguay's first National Water Plan
Authors: Lázaro Marila , Bortagaray Isabel , Trimble Micaela , Zurbriggen Cristina
Published: April 2021

As part of the formulation of the first National Water Plan (NWP) in Uruguay, a mini-public process called ‘Citizen Deliberation on Water (Deci Agua)’ was developed in 2016. While the draft of the plan was being discussed in the formal arenas of water governance (Basin Commissions and Regional Water Resources Councils), a University research team (led by the authors), in coordination with the national water authority, adapted the mechanism of consensus conferences in order to incorporate the citizens’ visions and to contribute to public understanding of the NWP challenges. This article analyses the main aspects of the developed participation strategy and discusses them regarding a set of quality criteria used to evaluate deliberative processes. Although the final version of the NWP (passed by decree in 2017) incorporated some of the contributions of the Citizen Panel, an in-depth analysis of the scope of the deliberative process of Deci Agua allows us to delve into some key aspects related to the quality of participation processes and the challenges. A mixed approach that combines stakeholder participation and lay citizens is novel and desirable in water governance since it increases the scope of participation, deepens the legitimacy of decision-making and improves the public debate.
Perfil do consumidor de vinhos em Lages – Santa Catarina
Authors: Würz Douglas André , Outemane Marcus
Published: April 2021

É importante identificar e definir os perfis de compradores para, depois, estabelecer estratégias de oferta compatíveis com esses diferentes perfis. Neste contexto, a segmentação do mercado é uma das principais aplicações. Tem-se como objetivo deste trabalho realizar uma análise sobre o perfil dos consumidores de vinhos e espumantes, em Lages, Santa Catarina. O presente trabalho apresenta um caráter exploratório-descritivo, com uma amostra para pesquisa de 150 consumidores de vinhos do município de Lages/SC, que apresentam hábito de consumir regularmente vinhos, para os quais foram aplicados questionários, de Março a Julho de 2017. Com a realização do presente trabalho, foi possível realizar uma caracterização do consumidor de vinhos em Lages, sendo estas informações relevantes para estratégias de mercado, buscando o aumento da comercialização e consumo de vinhos. Observou-se um consumo regular de vinhos entre os consumidores entrevistados, sendo o vinho tinto o estilo mais consumido entre os entrevistados, tendo como principais fatores na escolha de um vinho o preço, a variedade da uva, o conselho de amigos e a promoção. A origem do vinho possui grande importância, sendo caracterizada principalmente pelo país de origem, região de origem e pela vinícola. Para os consumidores entrevistados, a indicação geográfica representa uma garantia de qualidade, e garantia do local e método de elaboração, estando os consumidores dispostos a pagarem um valor superior por um vinho que possua uma indicação geográfica.
Avaliação do uso de terra de diatomácea para controle de Sitophilus zeamais em grãos de arroz com casca
Authors: Antunes Luidi Eric Guimarães , Gomes Dionello Rafael
Published: April 2021

O arroz está entre os grãos mais consumidos e produzidos no mundo, sendo responsável por alimentar em torno de 2,5 bilhões de pessoas, porém muito se perde devido ao ataque de insetos no armazenamento. Baseado nisso, se objetivou avaliar o uso da terra de diatomácea em grãos de arroz com casca quando infestados por adultos de Sitophilus zeamais. Foram utilizados grãos com teor de umidade inicial de 12 e 14%, sendo cada umidade tratada com doses de 0, 500, 1500 e 2500 g t-1 em dois períodos de infestação: 1 hora e 15 dias após a aplicação. Cada dose foi composta de cinco repetições contendo 100 g de grãos e 20 insetos adultos, para cada teor de umidade e período de infestação. Aos 30 e 60 dias após cada infestação, a mortalidade e emergência de Sitophilus zeamais foram analisadas. Perda de peso dos grãos e teor de umidade foram verificados somente aos 60 dias. Grãos livres de tratamento apresentaram menores valores de mortalidade de Sitophilus zeamais, diferindo estatisticamente dos demais, independente dos períodos de infestação. Independente do teor de umidade inicial e período de infestação, doses de terra de diatomácea de 1500 e 2500 g t-1 apresentaram mortalidade de Sitophilus zeamais entre 98 e 100%. Todos os tratamentos apresentaram teor de umidade final abaixo de 12%. Maiores perdas de peso foram verificadas em grãos com maior teor de umidade inicial. Desta forma, pode-se concluir que a terra de diatomácea apresenta ação satisfatória no controle de S. zeamais em grãos de arroz com casca quando estes entram em equilíbrio higroscópico abaixo de 12%.
Detecção de patógenose insetos-praga em pomares de louro em Paty do Alferes-R
Authors: Figueiredo Ana , Rodrigues da Silva Leirson , Aparecida Salgado de Morais Lilia
Published: April 2021

O louro (Laurus nobilis L.) é nativo do mediterrâneo e amplamente utilizado no mundo desde a antiguidade, devido às suas propriedades medicinais, alimentícias e beleza singular. No Brasil,o louro geralmente é cultivado em pequenos pomares, principalmente para o uso culinário, mas também, para obtenção de óleo essencial, como forma de agregar valor ao produto. À campo, a cultura sofre devido a forma de coleta extrativista e manejo precário, sem adoção de boas práticas agrícolas, favorecendo a ocorrência de patologias nos pomares. Perante a escassez de publicações sobre o tema, o objetivo deste estudo foi relatar a ocorrência de doenças e pragas no louro. Com base na sintomatologia, o material foi coletado e analisado. Os patógenos foram isolados pelo método direto e identificados, por meio de técnicas tradicionais de microscopia e chaves de identificação. Os fungos foram os fitopatógenos de maior ocorrência causando doenças no louro. Além disso, algumas plantas exibiam injúrias causadas por ataque de pragas, que podem causar danos e ainda, são potenciais transmissorasou facilitadoras da entrada de agentes patogênicos à planta.
New Strategies for Necrotizing Enterocolitis Diagnosis and Prevention in Newborns
Authors: Perrone Serafina , Cremonini Isabella , Marinelli Francesca , Monaco Sara , Nicoletti Laura , Giordano Maurizio , Esposito Susanna
Published: April 2021

Necrotizing enterocolitis is one of the most frequent and severe gastrointestinal diseases
that affect preterm newborns in Neonatal Intensive Care Units. It was firstly described in 1960s,
but this clinical entity was not widely recognized until the advent of modern neonatal intensive
care. The disease is characterized by submucosal edema, infiltration of intestinal wall by immune
cells, specifically neutrophils and, in severe forms, wall necrosis that leads to intestinal perforation.
Its incidence is inversely associated to birth weight and gestational age. Necrotizing enterocolitis
has been responsible for high rates of morbidity and mortality (15-30%), despite improvements
made in neonatal care in the last decades. The challenge is to optimize strategies for early diagnosis,
define the best medical and surgical treatments and standardize preventive measures. Several
biomarkers have been proposed for the early prediction of necrotizing enterocolitis onset in
preterm newborns and can be useful not only for diagnostic purposes but also for prediction of disease
progression and severity. The purpose of this paper is to illustrate the most recent evidence regarding
the diagnosis and prevention of necrotizing enterocolitis. This manuscript contributes to
clinical decision-making in preterm neonates at high risk of developing necrotizing enterocolitis.
Medication Without Harm: Developing Optimal Medication Error Reporting
Systems
Authors: Shiima Yuko , Malik Muzaffar , Okorie Michael
Published: April 2021

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Medication errors are amongst the most frequently occurring healthcare-related incidents
and have the potential to lead to life-threatening harm to patients. An incident reporting system
is a traditional approach to the improvement of patient safety and entails the retrieval of information
from incident reports. This not only provides a better understanding of causes and contributing
factors but also enables the collection of data on the severity of incidents, system deficiencies
and the role of human factors in safety incidents. Medication error reporting systems are often developed
as a part of larger incident reporting systems that deal with other types of incidents. Although
a rise in the prevalence of medication errors has led to an increased demand for medication
error reporting, little is known about the characteristics and limitations of medication error reporting
systems. The authors broach the subject of medication error reporting systems and propose a
more robust and standardized approach.
Green Synthesis of Five- and Six-membered N-heterocycles by Ultrasonic Irradiation in Aqueous Media
Authors: Nogueira Thais Cristina Mendonça , de Souza Marcus Vinicius Nora
Published: April 2021

Five- and six-membered N-heterocyclic compounds play an important role in medicinal
chemistry and the development of new drugs. There is a constant demand for the development of novel
biologically potent compounds, and there is also an increasing pressure to develop alternative and
more sustainable synthetic methodologies following the Green Chemistry principles. Thus, the present
review aims to compile the latest progress in the use of ultrasound irradiation in water conditions
to mediate the synthesis of five- and six-membered N-heterocyclic compounds in an environmentally
benign manner.