bluuebunny/crossref_metadata_2025 huggingface dataset:
Strategi Desain Integrasi Rumah Susun dan Fasilitas Pertanian Perkotaan berbasis Self-sufficiency
Authors: Ramadhikka Abhinaya , Purwani Ofita , Yuliani Sri
Published: April 2024

This paper focuses on the implementation of the concept of self-sufficiency in energy and food into residential buildings by adding agricultural facilities. There is still no specific literature on the application of self-sufficiency in residential buildings with urban agricultural facilities. Current literature. The current literature discusses self-suffiency in general, or the application of one aspect of self-suffiency in buildings, such as energy. In addition, the scale of discussion on large-scale self-sufficiency and not specific to residential buildings with urban agricultural facilities Therefore, this article can be one of the literature that discusses self-sufficiency specifically in residential buildings with urban agricultural facilities and on a microscale. Using theories from Mahdi, Magdalenna and Suharyanto , we formulate how to apply the self-sufficiency concept to the residential building by calculating the food and energy needed by the residents and how to achieve it. This project is a model of how to achieve self-sufficiency in residential buildings
Pendekatan Highest and Best Use dalam Pelestarian Bangunan Bersejarah
Authors: Danastri Yuwono Aisyah Pratita , Khairunnisa Amanda Aufa , Ikasanti Mesa Noor , Adilah Nada Haifa , Widiyani Widiyani
Published: April 2024

The concept of "Highest and Best Use" (HBU) refers to the optimal utilization of a property that would result in the highest value or benefit. In the context of a heritage building, which conceives historical or cultural significance, adaptive reuse concept becomes particularly relevant. Adaptive reuse involves repurposing a heritage building, such as a former factory building, for a new function that aligns with its historical and architectural characteristics. This approach allows for the preservation of the building's heritage value while also meeting contemporary needs and promoting sustainable development. This study examined the incorporation of HBU features in the three conversions of historical former factory buildings into tourist attractions, namely De Tjolomadoe, Rumah Atsiri, and The Heritage Palace. This study utilized four dimensions of HBU—the legal, physical, financial, and the maximum production dimension—to evaluate the three previous cases that employed adaptive reuse strategies. Results indicated that De Tjolomadoe serves as a noteworthy illustration of the effective implementation of HBU in renovating historical buildings, as evidenced by its achievements.
A CULTURE OF BUSINESS COMMUNICATION AMONG FUTURE DOCTORS IN HIGHER EDUCATION INSTITUTIONS: STATE OF DEVELOPMENT OF THE PROBLEM IN PSYCHOLOGICAL AND PEDAGOGICAL LITERATURE
Authors: Gren Larysa , Kachailo Kostyantyn
Published: April 2024

The article, based on the analysis of research by domestic authors, emphasizes the importance of forming a culture of business communication among representatives of “people-to-people” professions, in particular, among future doctors in institutions of higher education; considered the culture of business communication as one of the indicators of the general culture and moral qualities of the individual, which integrates the external culture, the culture of speech, the culture of feelings, the culture of behavior and etiquette; it has been proven that the knowledge, skills and professional communication skills that are formed and developed in the process of studying at an institution of higher medical education are especially important for a future doctor; the main psychological components of communication are given (a sense of presence, showing concern for another person, respect for the worldview and point of view of another person, empathy, sincerity as a prerequisite for free and open communication, respect); the decisive role of the pedagogical skill of teachers in the formation of the culture of business communication of future doctors in institutions of higher education is assigned.
PECULIARITIES OF FORMATION OF PROFESSIONAL COMPETENCE OF FUTURE BACHELORS OF CHEMICAL AND TECHNOLOGICAL PROFILE IN HIGHER EDUCATION INSTITUTIONS ON THE BASIS OF COMPETENCE APPROACH
Authors: Kurbanova Halida
Published: April 2024

The article reveals the essence of such concepts as “competence”, “professional competence”, it is proved that the level of their theoretical and practical training is of great importance in the formation of the professional competence of future bachelors of the chemical and technological profile; qualitative characteristics of the student are justified, the formation of which will contribute to his successful mastery of a technical specialty; attention is focused on the need for formation of gnostic, design, diagnostic, communicative, informational and analytical functions in future bachelors of a chemical and technological profile in a higher education institution, and the role of these functions in the formation of their professional competence is revealed; the educational and professional program “Oil, gas and solid fuel processing technologies” of the first (bachelor's) level of higher education, specialty 161 Chemical technologies and engineering (National Technical University “Kharkiv Polytechnic Institute”); with the aim of individualizing the educational trajectory and forming the professional competence of future chemical-technological bachelors, selective academic disciplines that can be included in the catalog of university disciplines are proposed, and their expediency is substantiated.
The Use of Metaverse in Providing Interactive Learning Experiences in Schools
Authors: Haryo Petrus , Makmur Amelia
Published: April 2024

The development of digital technology has played an increasingly important role in education, and the concept of the metaverse offers the potential to enhance the quality of learning. The implementation of metaverse in education is gradually taking place, but understanding and utilization are still limited, especially at the primary and secondary school levels. This is further reinforced by the fact that Indonesia still adheres to mass education or education 2.0. This statement reflects the limitations in understanding and utilizing the concept of metaverse in school-based learning. This research aims to explore the utilization of metaverse as an interactive learning tool in the school environment. The research method used is a survey method, with educators at the primary and secondary school levels as respondents. Quantitative descriptive analysis is employed to determine the values of the related variables. The results of this research show that 40.4% of the respondents state that integrating social media with the metaverse can enhance the engagement and relevance of learning, creating interesting and interactive learning experiences. The metaverse also supports virtual social interactions, collaborative learning, and strengthens relationships with learners from diverse backgrounds. However, 47.4% of the respondents state that the integration of metaverse in learning practices is still limited, and learners' understanding of the metaverse needs to be improved. Further efforts are needed to integrate the metaverse into learning practices at schools, develop effective learning materials, and address existing challenges. In conclusion, the use of metaverse in learning has the potential to enhance learner engagement, creativity, collaboration, and motivation, but it requires more intensive efforts to fully integrate it into learning practices at schools.
Development of A Book On Cultivating Manners For Pancasila And Citizenship Education Subjects For Class IV Elementary School Students
Authors: Sa'adah Fatikhatus
Published: April 2024

This study aimed to create a book that can assist kids in cultivating proper etiquette.   The research employed the Research and Development (R&D) method, utilising the ADDIE model, which consisted of five stages: Analysis, Design, Development, Implementation, and Evaluation. The data was collected through interviews and questionnaires. In addition, the data was analysed using two distinct stages: the expert evaluation stage and the product trial stage. The study’s findings, derived from expert testing, demonstrated the feasibility of the courtesy book yielded percentation comprised 95% of media experts, 88% of material experts, and 92% of linguists. The user conducted trials with students and achieved outstanding results in the One to One Evaluation (96%), Small Group (94%), and Field Test (94%), respectively. These findings demonstrated that the book product designed to inculcate courteousness in fourth-grade primary school students is appropriate for implementation.
Implementasi Kemala-Smart untuk Meningkatkan Kualitas Layanan Posyandu
Authors: Indrasari Widyaningrum , Ariyanti Shallu Fidhah , Hersaputra Nugraha , Nuvus Afiva Riyatun , Dewanti Kunti , Zulmi Febrian , Ramdhan Muhammad Rofiid , Subekti Fajar , Bahagia Marthin Virgo , Muliyati Dewi , Firmansyah Heri
Published: April 2024

Posyandu is one of the social institutions that plays a role in the community participation approach in the health sector. The quality and effectiveness of Posyandu depend on the role of Posyandu cadres. Posyandu cadres of Kemala Bhayangkari still use a manual approach in collecting data on toddler development. Using manual methods creates the potential for data errors, loss of information, and difficulties in accessing data. Through the Community Service Program of 2023, the smart sensing device has been developed using sensors system that is integrated with the Internet of Things (IoT). Furthermore, there is a Posyandu service website containing information about available services and data on the growth and development of toddlers. The success of implementing activities is assessed by participants through a questionnaire. The results achieved from this program show that the quality of the device, website and database system is very good (96%); the system is able to improve the quality of posyandu services, especially in the context of recording and reporting growth and development data at Posyandu Kemala Bhayangkari Ciracas (93%); and the need for posyandu cadres assistance and continuity of activities (93%).
 
Abstrak
Posyandu merupakan salah satu pranata sosial yang berperan dalam pendekatan partisipasi masyarakat di bidang kesehatan. Kualitas dan efektivitas Posyandu bergantung pada peran kader Posyandu. Kader Posyandu Kemala Bhayangkari masih menggunakan pendekatan manual dalam pendataan perkembangan balita. Penggunaan metode manual menimbulkan potensi kesalahan data, kehilangan informasi, dan kesulitan dalam mengakses data. Pada Program Pengabdian Kepada Masyarakat Terintegrasi Kuliah Kerja Nyata (PKM-KKN) tahun 2023, telah dikembangkan alat sensor cerdas menggunakan sistem sensor  yang terintegrasi dengan Internet of Things (IoT). Selain itu, terdapat situs web layanan Posyandu berisi informasi seputar layanan yang tersedia dan data tumbuh kembang balita. Keberhasilan pelaksanaan kegiatan dinilai oleh peserta melalui kuisioner. Hasil yang dicapai dari program ini menunjukan bahwa  kualitas alat, situs web, dan sistem database yang dikembangkan sangat baik (96 %); sistem yang dikembangkan mampu meningkatkan mutu layanan posyandu khususnya dalam rangka pencatatan dan pelaporan data tumbuh kembang di Posyandu Kemala Bhayangkari Ciracas  (93 %); dan perlu adanya keberlanjutan kegiatan (93%).
Literasi Keuangan untuk Menumbuhkan Kecerdasan Finansial Mahasiswa
Authors: Kurnianti Destria , Khairunnisa Hera , Handarini Dwi , Marsofiyati  , Anwar Choirul , Dianta Karuniana , Yusuf Muhammad , Mundhiharno  , Yaacob Mohd Hasimi , Malzara Vidia Ratu Balqis , Sari Rini Nurmala , Haneul  , Safitri Gita
Published: April 2024

This community service is aimed to teach students about the important role of financial literacy in shaping students' understanding of personal financial aspects. The participants of this activity is students of the Faculty of Economics, Universitas Negeri Jakarta. To teach financial literacy to students, the research team invited a lecturer speaker and a speaker from Finansialku as a digital financial application to give knowledge about about financial planning, investment, and debt management. The outcome of this event is the findings that provide insight into the effectiveness of financial literacy training and its potential impact on students' financial lives.
 
Abstrak
Pengabdian masyarakat ini bertujuan untuk mengajarkan kepada mahasiswa tentang peran penting literasi keuangan dalam membentuk pemahaman mahasiswa terhadap aspek keuangan pribadi. Peserta kegiatan ini adalah mahasiswa Fakultas Ekonomi Universitas Negeri Jakarta. Untuk mengajarkan literasi keuangan kepada mahasiswa, tim peneliti mengundang pembicara dosen dan pembicara dari Finansialku sebagai aplikasi keuangan digital untuk memberikan pengetahuan mengenai perencanaan keuangan, investasi, dan pengelolaan utang. Hasil dari kegiatan ini adalah temuan yang memberikan wawasan tentang efektivitas pelatihan literasi keuangan dan potensi dampaknya terhadap kehidupan keuangan mahasiswa.
Experience and Perspective: Population Administration Services in Delta City
Authors: Bahlamar Ahmad  Riyadh Umar
Published: April 2024

Policy implementation is an important indicator that has a major influence on the success of policies related to public issues. This study aims to analyze and explain the implementation of population administration service policies in Sidoarjo Regency. The basic concept used is Edwards III's policy implementation theory. This qualitative research uses a purposive sampling technique. Data were collected using interviews, observation, and documentation. Data analysis used interactive Miles, Huberman, and Saldana. The research results show that population administration service policies in Sidoarjo Regency have demonstrated adequate quality, but still require innovation and development to increase reliability, speed and management innovation. In Tulangan District, there are obstacles in communication due to the lack of service flow boards and inconsistencies in service times. Meanwhile in Porong District, population administration requirements are good with competent officers, clear service flow boards, and high consistency of service times. Human resources in Porong District are considered good and fast, while in Tulangan District they are quite good. Regarding disposition, both sub-districts provide services according to the needs of their residents. However, regarding the bureaucratic structure, Tulangan District has good SOPs, while Porong District experiences problems in the unclear distribution of the main tasks and functions of village officials.
HUBUNGAN KARAKTERISTIK PEKERJA DAN IKLIM KESELAMATAN KERJA DENGAN PERILAKU TIDAK AMAN PEKERJA OPERASIONAL PT. BINTAN RESORT CAKRAWALA
Authors: Dewi Ruri Sukmawati , Kusmawan David , Sari Rumita Ena
Published: April 2024

Iklim keselamatan kerja dan karakteristik individu berupa umur, jenis kelamin, pendidikan, pengalaman pelatihan, masa kerja dan status perkawinan memiliki pengaruh terhadap perilaku tidak aman. Tujuan penelitian ini adalah untuk melihat gambaran iklim keselamatan kerja, perilaku tidak aman, serta hubungan antara karakteristik dan iklim keselamatan kerja terhadap perilaku tidak aman. Desain penelitian ini merupakan penelitian kuantitatif dengan pendekatan cross sectional. Penghitungan sampel menggunakan metode simple random sampling dengan jumlah 194 sampel. Kesimpulan dalam penelitian ini Mayoritas pekerja memiliki tingkat pendidikan tinggi namun sebagian besar belum pernah mengikuti pelatihan dengan status masa kerja diatas lima tahun. Terdapat hubungan antara tingkat pendidikan (PR 1,971, 95%CI 0,721-5,393), pelatihan (PR 2,618, 95%CI 1,185-5,784), masa kerja (PR 2,197, 95%CI 1,165-4,413), status perkawinan (PR 1,509, 95%CI 0,493-4,621) dengan perilaku tidak aman. Proporsi perilaku tidak aman sebesar 16% dan kondisi iklim keselamatan yang tidak baik dengan skor mean <2,70.  Terdapat hubungan yang signifikan antara dimensi iklim keselamatan terhadap perilaku tidak aman.
Compilation of Apatite Fission-Track Data from the Northeast Atlantic Realm: A Jigsaw Puzzle with Missing Pieces
Authors: Jess Scott , Gröger Heike , Hendriks Bert , Peace Alexander , Schiffer Christian
Published: April 2024

The northeast (NE) Atlantic is one of the best-studied geological regions in the world, incorporating a wide array of geological phenomena including extensional tectonism, passive margin development, orogenesis, and breakup-related volcanism. Apatite fission-track (AFT) thermochronology has been an important tool in studying the onshore evolution of the NE Atlantic for several decades. Unfortunately, large regional-scale studies are rare, making it difficult to study geological processes across the whole region. In this work, a compilation of published AFT data is presented from across Fennoscandia, the British Isles, East Greenland, and Svalbard, with the goal of providing an accessible overview of the data and how this vast body of work has improved our understanding of the region’s evolution. Alongside a review of previous literature, interpolated maps of fission track age and mean track length (MTL) highlight regional trends in the data that may result from major first-order processes and areas of low sample density that should be targeted for future study. Additionally, in the absence of metadata required for thermal history modeling, apparent exhumation rate estimates are calculated from available elevation profiles and the timing of major exhumation events inferred from “boomerang plots” of fission track ages against MTL values. Across Fennoscandia, data suggests that the opening of the NE Atlantic and exhumation of the margin have clearly played a major role in the thermal history of the upper crust. The remaining areas of Britain, Ireland, East Greenland, and Svalbard all present more complex trends consistent with a combination of the NE Atlantic’s opening and the interplay between specific bedrock geology of sampling sites and localized geological processes. Areas of low sample density include southern Britain, NE Britain, southeast Greenland, southern Svalbard, and Eastern Fennoscandia, each of which provides the natural laboratory required to answer many unresolved questions.
Las Relaciones de conflicto en las comunidades indígenas dela provincia minera de Yauli. Siglos XVIII-XIX
Authors: Gomez Solano Cristhian Manuel
Published: April 2024

Conflicts involving peasant communities in mining areas are currently recurring in Peru. These have ancient antecedents, as is the case of the province of Yauli, where mining activity has been practiced since the 18th century. The objective of this work is to characterize the conflict relationships, starting with the arrival of mining activity in the area. This paper was carried out through case studies and the review of, mainly, documentation for land disputes, existing in the archives of the peasant communities of the province of Yauli. It is concluded that, in this mining province, during the 18th and 19th centuries, conflict relationships were configured that can be characterized —according to the actors involved and the identities resulting from the social phenomenon— as intra-communal, inter-communal and extra-communal. Likewise, socio-economic and ethnic differentiations, which are not mutually exclusive, have been identified since the 18th century within indigenous communities.
Diseño de una estrategia de comunicación pública de laciencia sobre patrimonio cultural y arte local en el centrode la provincia de Buenos Aires (Argentina)
Authors: Giacomasso María Vanesa , Conforti María Eugenia
Published: April 2024

The communication of cultural heritage studies does not always constitute a central action of research projects. Therefore, the objective of this work is to present the design of a public science communication strategy on cultural heritage and local art in the district of Olavarría (Argentina). The proposal arises from the making of a documentary and its low visibility and exchange with the public. To achieve this, methodologically it is proposed to work from communication planning based on contextual models and citizen participation. The main result is the development of a communication strategy, based on transmedia formats and focused on the local educational sector. It concludes on the importance of articulating cultural heritage research with social sectors that are susceptible to becoming aware of their environment and that have a high potential to get involved in its protection and safeguarding.
A multicentric, randomised, controlled clinical trial to study the impact of bedside model-informed precision dosing of vancomycin in critically ill children – BENEFICIAL trial
Authors: De Cock Pieter Albert , Colman Roos , Amza Anca , De Paepe Peter , De Pla Hans , Vanlanduyt Lieselot , Linden Dimitri Van Der
Published: April 2024

Background
Vancomycin is a commonly prescribed antibiotic to treat serious Gram-positive infections in children. The efficacy of vancomycin is known to be directly related to the pharmacokinetic/pharmacodynamic (PK/PD) index of the area under the concentration-time curve (AUC) divided by the minimal inhibitory concentration (MIC) of the pathogen. In most countries, steady state plasma concentrations are used as a surrogate parameter for this target AUC/MIC, but this practice has some drawbacks. Hence, AUC-based dosing using model-informed precision dosing (MIPD) tools has been proposed for increasing target attainment rate and reducing vancomycin-related nephrotoxicity. Solid scientific evidence for these claimed benefits is lacking in children. This randomized controlled trial aims to investigate the large-scale utility of MIPD dosing of vancomycin in critically ill children.
Methods
Participants from 14 neonatal intensive care, pediatric intensive care and pediatric haemo-oncology ward units from 7 hospitals are randomly allocated to the intervention or standard-of-care comparator group. In the intervention group, a MIPD dosing calculator is used for AUC-based dosing, in combination with extra sampling for therapeutic drug monitoring in the first hours of treatment, as compared to standard-of-care. An AUC24h between 400 to 600 is targeted, assuming an MIC of 1 mg/L. Patients in the comparator group receive standard-of-care dosing and monitoring according to institutional guidelines. The primary endpoint is the proportion of patients reaching the target AUC24h/MIC of 400–600 between 24 and 48 hours after start of vancomycin treatment. Secondary endpoints are the proportion of patients with (worsening) acute kidney injury during vancomycin treatment, the proportion of patients reaching target AUC24h/MIC of 400–600 between 48 and 72 hours after start of vancomycin treatment, time to clinical cure, ward unit length-of-stay, hospital length-of-stay and 30 day all-cause mortality.
Discussion
This trial will clarify the propagated benefits and provide new insights into how to optimally monitoring vancomycin treatment in critically ill children.
Trial registration
Trial Registration: Eudract number:2019-004538-40, registered: 2020-09-08
Overexpression of EZH2 is associated with clinicopathological parameters and poor prognosis in gliomas
Authors: Peng Can , Chen Wei , Yang Jun , Wang Li , Lu Lixia , Ge Rong
Published: April 2024

Histone methyltransferase EZH2, primarily localized in the nucleus, mediates constitutive Polycomb repressive complex activity by trimethylating lysine 27 of histone H3 (H3K27me3), leading to gene silencing through canonical and noncanonical mechanisms, resulting in transcriptional repression or activation. Its involvement is crucial in cell growth, proliferation, differentiation, and apoptosis, with its effects linked to the regulation of various targets and signaling pathways. Overexpression of EZH2 alters gene expression and function, thereby facilitating cancer progression. Recent research has identified the potential prognostic role of EZH2 expression in glioma patients. This study assesses the clinicopathological significance and prognostic value of EZH2 expression in gliomas using available data. The mRNA levels of EZH2 in tumor tissues and normal tissues were assessed using timer2.0 and data from CGCA and TGCA. The prognostic significance of EZH2 mRNA expression was determined using Kaplan-Meier plotter. A total of 147 clinical samples from glioma patients underwent immunohistochemistry analysis to evaluate EZH2 protein expression. Cox proportional hazards regression model and Kaplan-Meier survival curves were employed to assess the relationship between EZH2 expression, clinicopathological parameters, and overall survival (OS). Across multiple tumor cohorts, EZH2 was found to be upregulated and amplified in tumor tissues. In high-grade glioma patients, EZH2 expression was significantly increased, and higher EZH2 expression correlated with poorer OS, disease-specific survival (DSS), and progression-free interval (PFI). Therefore, the level of EZH2 may serve as a prognostic biomarker for glioma patients.
Expression of TNF-α, VEGF-A and microvessel density in cerebral alveolar echinococcosis and their correlation with perilesional brain edema
Authors: Wumier Wuerken , Abulizi Alimasi , Wu Pengfei , Jinsihan Najiahai , Wang Yongxin , Duysenbi Serick , Wang Zengliang
Published: April 2024

Alveolar echinococcosis (AE) is an infrequent zoonosis caused by Echinococcus multilocularis with a high degree of disability and mortality. Metastatic cerebral alveolar echinococcosis (CAE) is very rare and the lesions could lead to severe perilesional brain edema (PLBE) and subsequent uncontrollable intracranial hypertension. In this study, we sought to determine the expression of edema-associated factors in CAE lesions and their associations with PLBE. We retrospectively evaluated the clinical data of 18 CAE patients who received craniotomy. Severity of PLBE was described by edema index (EI). Archived specimens were processed for immunohistochemistry to detect tumor necrosis factor alpha (TNF-α), vascular endothelial growth factor A (VEGF-A) and microvessel density (MVD) in CAE lesions. Expression intensity of CAE lesions was quantified by integral optical density (IOD) or count and was compared to the control group. The results showed TNF-α and VEGF-A were significantly expressed in CAE lesions (p < 0.001), their levels were positively correlated with PLBE (TNF-α: r = 0.701, p = 0.001; VEGF-A: r = 0.803, p < 0.001). The MVD of CAE lesions had a similar expression with normal brain tissue, and it was positively correlated with PLBE and VEGF-A (PLBE: r = 0.849, p < 0.001; VEGF-A: r = 0.687, p = 0.002). In conclusion, we speculated the upregulation of TNF-α and VEGF-A induced the formation of PLBE. Besides, though there was no extra increase of MVD, it was still regulated by VEGF-A and provided a better anatomical basis for the formation of PLBE and further promoted it.
Wild Fire Classification using Learning Robust Visual Features
Authors: Fan Xianjing , Zhu Taoyuan , Zi Xing , Tao Xian , Prasad Mukesh
Published: April 2024

The diversity in the texture, color, and shape of flames, and their similarity to most sunset skies and red forests, has always made reducing false alarms in forest fire detection a challenging task. Traditional image processing methods rely too heavily on manual feature annotation. Using conventional machine learning models can effectively extract flame characteristics and reduce the error rate of manual annotation, but their limited local perception often leads to a high rate of false alarms. This paper proposes the use of the self-supervised model with Learning Robust Visual Features (DINOV2) for feature extraction, and a classification head for categorizing forest fires. In tests across most fire datasets, DINOV2 achieved an accuracy rate of up to 99% while simultaneously reducing the rate of false alarms.
Weighted pseudo almost automorphic mild solutions for two-term fractional order differential equations via measure theory
Authors: Boukli-Hacene Nadira , Djoubir Baya , Ezzinbi Khalil
Published: April 2024

In this article, we show sufficient conditions ensuring the existence and uniqueness of pseudo almost automorphic solution using measure theory to the two-term fractional order differential equation in the form\begin{equation*} D_{t}^{\alpha}u'(t)+\gamma D_{t}^{\beta}u(t)= Au(t)+D_{t}^{\alpha}f(t,u(t)), t\in\mathbb{R},0<\alpha \leqslant \beta < 1,\gamma \geqslant 0.\end{equation*}Where \(A\) is a sectorial operator of angle \(\beta \frac{\pi}{2}\) , the fractional derivative is understood in the Weyl sense and the forcing term \(f\) of the equation is \(\mu\) -Stepanov-like pseudo almost automorphic function, $\mu$ is a positive measure on \(\mathbb{R}\) . An example is given for illustration.
Kinematics and spatial structure analysis of TBM gunite robot based on D-H parameter method
Authors: Jia Lianhui , Liu Shenyao , Cao Chenxu , Kang Yehao , Zhu Ying , Wang Lijun , Cheng Ruixue , Xu Donglai
Published: April 2024

In modern tunnel construction, TBM (Tunnel Boring Machine) plays a very important role. In response to the needs of tunnel wall reinforcement and TBM automated construction for tunnel construction, a shotcrete mechanism mounted on the TBM is designed. In order to evaluate the kinematic performance of the mechanism, this paper studies the forward and inverse kinematics and spatial architecture of the TBM shotcrete robot. Firstly, based on the D-H parameter method, the number of joints and links is determined and structural analysis is performed to obtain the robot's forward kinematics equation, achieving the mapping between joint space and pose space. Then, by determining the joint variables, the mapping of the end tool in Cartesian space is achieved. Finally, based on the Monte Carlo random sampling method, the workspace of the robot is constructed, and its reachability and flexibility within the robot workspace are evaluated. The performance of the device is verified by building a prototype, which meets the requirements well. Through the research in this paper, it can provide theoretical basis and guidance for the design and control of the shotcrete robot.
Clinical Characteristics of HIV-Associated Tracheobronchial Talaromyces marneffei Infection in Seven Patients in Guangxi, China
Authors: Pan Mianluan , Wu Hongjie , Lin Hairong , Peng Zhimin , Huang Jie , Zhang Jianquan
Published: April 2024

Objectives: Tracheobronchial Talaromyces marneffei (TM) infections among HIV-infected patients are rare. To improve understanding, we analysed the clinical features, immune mechanisms, treatment, and prognosis.
Methods: We collected clinical information from patients with talaromycosis admitted to the Fourth People’s Hospital of Nanning from January 2015 to June 2022 and retrospectively analyzed their clinical characteristics and prognosis.
Results: HIV-positive patients (n = 1567) were enrolled. Of seven patients with tracheobronchial T. marneffei infection were all men with a median age of 48 years (range 39–50 years). Cough, sputum, fever, and weight loss were the most common symptoms. The total white blood cell count was normal or decreased, and all lymphocyte counts decreased. All patients had reduced CD4+ T-cell counts, below 50 cells/μL. Chest CT imaging signs included patchy signals or large areas of exudation. Endoscopically, the trachea and bronchial mucosa showed congestion, edema, surface attachment, nodules, lumen stenosis, obstruction, etc. T. marneffei spores were found on bronchial mucosal pathology in all 7 cases. Five patients were initially treated with intravenous infusion of amphotericin B for 2 weeks, followed by oral itraconazole capsules (200 mg) twice daily, and two patients were initially treated with itraconazole. Four patients were cured, 2 improved, and 1 died.
Conclusions: It is suggested that bronchoscopy should be performed in HIV-positive patients with pulmonary lesions to improve the diagnostic rate of tracheobronchial T. marneffei.
Development of an eco-friendly voltammetric approach for determination of anti-coagulant drug edoxaban by highly sensitive iron oxide prob
Authors: Rizk Mohamed. , Hendawy Hassan A. M. , Elkhalek Ola Abd , El-Alamin Maha Mahmoud Abou
Published: April 2024

Edoxaban tosylate monohydrate (EDTM) is a direct oral anticoagulant drug that has recently been incorporated into most COVID-19 treatment protocols as either prophylaxis or therapy because it is effective and safe in the treatment of coagulopathy that is life-threatening in post-COVID-19. So, we developed a new, eco-friendly, sensitive differential pulse voltammetric method using 10.0% iron oxide nanoparticles as a modified carbon paste electrode (10.0% Fe2O3/CPE) in 0.1M borate buffer pH 10.0 as a supporting electrolyte. The electrochemical behavior of EDTM confirmed irreversible diffusion-controlled oxidation. Our modified sensor (10.0% Fe2O3/CPE) showed high sensitivity with a linear relationship between the peak current and EDTM concentration over the concentration range of 200–3500 ng/mL with a correlation coefficient of 0.9995, a limit of detection of 60 ng/mL, and a limit of quantification of 100 ng/mL. Our suggested method was successfully applied in bulk, pharmaceutical dosage form, spiked human plasma, and urine with high recovery 100.81% ±1.48 The results were statistically compared with the reported method and found to be in good agreement with it.
Movie Review System Using Machine Learning
Authors: Mishra Rahul Mishra Rahul , Hemant Hemant , Bajaj Parveen Kumar Bajaj Parveen Kumar
Published: April 2024

Sentiment analysis, the natural language processing (NLP) industry, is concerned with discerning the emotional context of text. In the realm of movie reviews, sentiment analysis automates the task of determining whether a review conveys positive, negative, or neutral sentiment. This automation is beneficial for both moviegoers and industry stakeholders, as it provides valuable insights into audience reactions. Through the development of a basic sentiment analysis model using NLP techniques, we can effectively categorize movie reviews, offering valuable information to movie enthusiasts and aiding them in making informed decisions.
Hereditary thrombotic thrombocytopenic purpura mimicking idiopathic thrombocytopenic purpura was revealed by miscarriage——Novel Compound Heterozygous Mutations in hTTP
Authors: Zhou Ruiqing , Wang Jiahuan , Wang Shunqing , Li Yumiao , Xu Shilin , Mo Wenjian
Published: April 2024

We report a case of early-onset hereditary thrombotic thrombocytopenic purpura in a 16-years old girl, who suffered from solely thrombocytopenia and was misdiagnosed as idiopathic thrombocytopenic purpura for years until two failed gestations finally revealed the underlying cause. Novel compound heterozygous mutations c.2865G>A:p.Trp955X and c.721delG:p.Gly241fs in ADAMTS13 gene were found and were predicted to be associated with the disease. She responded to plasma therapy but renal dysfunction may remain longstanding.
An extended Combined-TAM-TPB to explain the intention to adopt electric vehicles: a multi-group analysis of Generations X, Y, and Z
Authors: Poon Wai Chuen , Sin Kit Yeng , Sathasivam Kavitha
Published: April 2024

This study aims to examine the purchasing intention of electric vehicles among consumers belonging to Generations X, Y, and Z in an expanding market. The study examines how factors like perceived usefulness (PU), perceived ease of use (PEOU), attitude (ATT), subjective norms (SN), perceived behavioural control (PBC), technology enthusiasm (TE), environmental enthusiasm (EE), emotional value (EV), social image (SOIM), and social influence (SOIN) impact the probability of adopting electric vehicles. 658 valid responses were collected from people in Malaysia using structured surveys. Perceived usefulness and perceived ease of use were found to have a positive correlation with attitude. Attitude, subjective norms, perceived behavioural control, technical enthusiasm, emotional value, and social influence were found to influence intention, but environmental enthusiasm and social image did not have a significant effect on consumer intention. This study enhanced the combined framework of the theory of planned behaviour and technology acceptance model (C-TAM-TPB) by including five additional variables: technological and environmental enthusiasm, emotional value, social image, and social influence, to improve the understanding of consumers' intentions to buy electric cars in Malaysia. It provided insightful views on the various aspects influencing the readiness of Generations X, Y, and Z to adopt electric vehicles.
PtPd catalysts dispersed on coal-based nitrogen-doped carbon nanotubes for formic acid electro-oxidation
Authors: Wu Bohua , Liu Yifan , Wu Changqing , Wang Haiting , Wang Xiaoqin , Xiong Shanxin
Published: April 2024

Using coal-based polyaniline as carbon source and nitrogen source, nitrogen-doped carbon nanotubes (NCNTs) were successfully prepared through a two-stage furnace process. The PtPd/NCNTs catalysts were synthesized by the ethylene glycol reduction method. The results of transmission electron microscopy (TEM) show that the PtPd nanoparticles with an averaged diameter 3.1 ± 0.5 nm uniformly support on the surface of NCNTs. The X-ray photoelectron spectroscopy (XPS) reveals that nitrogen mainly exists in graphite states in NCNTs. The electrocatalytic activity of PtPd/NCNTs catalyst was tested by CO stripping voltammetry, cyclic voltammetry (CV) and chronoamperometry (CA). The electrochemical characterization shows that the PtPd/NCNTs catalyst exhibited higher electrocatalytic activity and stability towards formic acid oxidation, while its forward peak current density (549.83 mA mg− 1) is 4.5 times higher than that of PtPd/CNTs (120.90 mA mg− 1). The developed NCNTs are highly promising catalyst supports for direct formic acid fuel cells.
Alteration of Serum Lipid Profiles among Amoebasis and Giardiasis Confirmed Patients at North West Ethiopia
Authors: Semaw Muluken , Megabiew Fenthun , Walle Muluken , Woldesenbet Dagmawi , Tamir Mebratu , Mekuanint Amare , Mengesha Abebe Yenesew , Cherie Negesse , Berta Dereje Mengesha , Teketelew Bisrat Birke , Angelo Abiy Ayele , Abere Aberham , mihiret yenesew , Eshetu Tegegne
Published: April 2024

Background: Amoebiasis and giardiasis, common intestinal infections caused by Entamoeba histolytica and Giardia lamblia parasite. These agents are dependent of host-derived lipids for their membrane biogenesis and potentially alter host serum lipid profiles, might results in cardiovascular complications. Yet, limited studies have investigated the association between the infections and lipid profiles in Ethiopia.
Methods: A cross-sectional study was conducted from July 10 to August 252023. A total of 180 study participants were recruited using a convenient sampling technique. Socio-demographic and clinical data were collected using structured questionnaires via face-to face interviews and reviewing medical records, respectively. Approximately 5 grams of stool samples were collected and examined under a light microscope. Three milliliters of blood were collected from the case and control groups. The blood samples were then centrifuged to separate the serum from the whole blood. Subsequently, the lipid profiles were analyzed using a Coulter chemistry analyzer. The data were entered into epidata version (4.6), and exported into SPSS (25) for analysis. The lipid profile parameters of case were assessed and compared with healthy control groups using one way ANOVA. A P-value < 0.05 was considered as statistically significant.
Result: The study showed that E. histolytica/dispar-infected patients had significantly lower mean serum total cholesterol (120.21 ± 40.11), HDL (33.73 ± 13.36), and LDL (74.63 ± 32.93) levels compared to healthy groups. Additionally, the median interquartile range of triglyceride value decreased in E. histolytica/dispar infected patients (P ≤ 0.05). Likewise, patients infected with G. lamblia had lower mean serum total cholesterol (123.46 ± 48.18), HDL (34.30 ± 14.30), and LDL (73.57 ± 42.65) levels compared to healthy groups. Also, the median interquartile range of triglyceride value was lower in Giardia-infected patients (P≤0.05).
Conclusion: This study confirmed that E. histolytica/dispar and G. lamblia has significantly altered blood lipid levels in infected patients. Requires routine lipid panel analysis for these cohorts.
Sex and age differentials among people living with hypertension across the life course: evidence from a national survey in Bangladesh
Authors: Iqbal Afrin , Rahman Mahabubur , Bashar Mamun Ibn , Ahmed Ambar , Khan Shusmita , Ahmed Nahin , Hasan Mohammad Mehedi , Haider M Moinuddin
Published: April 2024

Background Globally, across many regions, the prevalence of hypertension is higher among men aged ≥ 30 years, but for Bangladesh, a national survey depicts a contrast from the norm. In this paper, we examine the sex and age difference in hypertension among the Bangladeshi population and explore its associated factors.Methods Secondary analysis was conducted using data from the Bangladesh Demographic and Health Survey (BDHS) 2017–2018, a nationally representative survey that involved a two-stage stratified sample of 675 households in urban (250) and rural (425) enumeration areas. The analytical sample consisted of 12,476 individuals aged 18 or older (6,955 women and 5,521 men). We conducted univariate and bivariate tests to analyze hypertension variations across sex, age, and other factors. We used multivariable logistic regression models and logit-based marginal probabilities to investigate age and sex differences as well as their interactions in hypertension while estimating the marginal effects of sex for each age-group to assess the significance of sex differentials in hypertension across the life course.Results Our study revealed a noteworthy trend: Women have a 5-percentage point lower hypertension prevalence than men in their early twenties, but this reverses when women reach their early thirties, with a 5-percentage point higher prevalence compared to men. After adjusting for confounders and age-sex interaction in females, the odds of hypertension were significantly higher (AOR: 3.6, 95% CI: 1.9–6.6) in the 35–39 years age-group, potentially leading to a combined burden of chronic and reproductive morbidity.Conclusion With rising hypertension and stagnant maternal health in Bangladesh, women of reproductive age face higher risks of chronic and reproductive complications, impacting maternal mortality and morbidity and burdening the healthcare system. Recognizing common factors contributing to early hypertension in Bangladeshi women enables targeted interventions, model testing, and strategic adjustments to the national non-communicable disease management pathway.
Dynamics of early-life bacteriophage- bacteria interactions in very preterm infants and their implications in disease
Authors: Jakobsen Rasmus Riemer , Cionci Nicole Bozzi , Gaggìa Francesca , Kot Witold Piotr , Pietrella Elisa , Berardi Alberto , Gioia Diana Di , Nielsen Dennis Sandris
Published: April 2024

Background
Preterm infants, especially if born very premature (before week 32 of gestation), are characterised by having immature organs including the gastrointestinal tract, associated with a skewed gut microbiota maturation and increased risk of gastrointestinal disorders. Early life gut microbiota maturation is crucial for various biological functions, influencing host metabolism, immune response, and pathogen protection. While the maturation of the bacterial gut microbiota component in preterm infants is well studied, very little is known about the interplay between these bacteria and their viruses, i.e. bacteriophages. This study focuses on the faecal bacterial and bacteriophage communities of very preterm infants during their first 90 days of life.
Methods
A prospective cohort including 23 very preterm infants (28 weeks' gestation or birth weight under 1000 g) in a Neonatal Intensive Care Unit in Italy was recruited. The majority (20/23) received antibiotic therapy in this period. Faecal samples were collected at birth and at 15, 30, and 90 days of life for 16S rRNA gene amplicon and metavirome sequencing. Analyses were performed to assess bacterial and viral composition, their interactions and their correlation with clinical parameters.
Results
Caudoviricetes members were the dominant bacteriophages, while facultative anaerobes dominated the bacterial community in the preterm infants' gut. The bacterial diversity increased over time, whereas bacteriophage diversity decreased and trans-kingdom interaction analysis revealed distinct clusters of co-occurring bacteria and bacteriophages. Notably, twin pairs exhibited higher virome similarity compared to bacterial community similarity. Antibiotic treatment correlated strongly with bacterial community composition and modestly with virome composition. Bronchopulmonary dysplasia (BPD) incidence and predicted viral host composition significantly correlated, suggesting a potential role of bacteriophages in disease aetiology.
Conclusion
This study provides a view on the complex interplay between bacterial and viral components in the preterm infant gut. We find that of bacteriophages appear to have a pivotal role in shaping the bacterial community before a more stable microbiota is reached. Furthermore we show that BPD and viral host composition are linked, suggesting that the preterm gut virome might be an important factor to consider in managing premature birth complications.
The efficacy of allelopathy of select lichens on antioxidant potential and multiplication of Ceratophyllum demersum L.
Authors: Tokgoz Ayse , Emsen Bugrahan , Dogan Muhammet
Published: April 2024

We aimed to investigate growth-promoting effect of Dermatocarpon miniatum and Parmelia saxatilis lichens on Ceratophyllum demersum propagated in vitro. Furthermore, we revealed antioxidant capacity variation in lichen-treated plant (allelopathic plant). C. demersum was subjected to methanol and water extracts from lichens, specifically D. miniatum and P. saxatilis. The most positive growth outcomes were witnessed when C. demersum was subjected to a methanol extract derived from P. saxatilis. We further examined DPPH scavenging and metal chelating activities, as well as total phenol and flavonoid contents, of the most robust allelopathic plants compared to control plants. Based on IC50 values, allelopathic plants exhibited greater efficacy in terms of DPPH scavenging and metal chelation activities in comparison with control. When we analyzed total phenols and flavonoids, both allelopathic plant samples, treated with both extracts, exhibited significantly higher levels (p < 0.05) compared to control. Methanol extract from allelopathic sample had maximum total phenol content (73.93 µg gallic acid equivalent/mg extract) and flavonoid content (66.26 µg quercetin equivalent/mg extract). In conclusion, this study will provide valuable input for future investigation in domain of plant development control and augmentation of biologically active substance propagation in plants, with a particular focus on utilizing P. saxatilis lichen.