bluuebunny/crossref_metadata_2025 huggingface dataset:
Genetic diversity and Wolbachia infection in the Japanese encephalitis virus vector Culex tritaeniorhynchus in the Republic of Korea
Authors: Jeon Jiseung , Kim Heung Chul , Donnelly Martin J. , Choi Kwang Shik
Published: December 2024

Background

Culex tritaeniorhynchus, a major vector of Japanese encephalitis virus (JEV), is found across a broad geographical range, including Africa, Asia, Australia and Europe. Understanding the population structure and genetic diversity of pathogen vectors is increasingly seen as important for effective disease control. In China and Japan, two countries in close proximity to the Republic of Korea (ROK), Cx. tritaeniorhynchus has been categorized into two clades based on the DNA barcoding region of mitochondrial cytochrome c oxidase subunit I (COI), suggesting the presence of cryptic species. No comprehensive analysis of the genetic diversity in Cx. tritaeniorhynchus has been conducted in the ROK. To address this gap, we investigated the population structure of Cx. tritaeniorhynchus in the ROK.

Methods

In Daegu, mosquito collections were conducted over a 2-year period from 2022 to 2023. For all other regions, Cx. tritaeniorhynchus specimens collected in 2023 were used. The COI barcoding region was analyzed to determine the genetic structure of the populations, supplemented with data from the 28S ribosomal DNA region. Each population was also examined for the eventual presence of Wolbachia infection. Finally, a back trajectory analysis was conducted to assess the possibility of international introduction of Cx. tritaeniorhynchus into the ROK.

Results

The analysis of the COI region revealed the presence of two distinct clades within Cx. tritaeniorhynchus; these clades were the same as Cx. tritaeniorhynchus continental type (Ct-C) and C. tritaeniorhynchus Japanese type (Ct-J) previously reported. In contrast, the nuclear 28S region showed no significant genetic differentiation between these clades. Wolbachia infection was confirmed in some populations, but there was no evidence of an association with Wolbachia in Ct-C and Ct-J. It was also confirmed that the ROK is currently dominated by the Ct-J clade, with a possible introduction of Ct-C via air currents.

Conclusions

Determining the presence of cryptic species is important for preventing vector-borne diseases. The results of this study confirm the existence of two clades of Cx. tritaeniorhynchus in the ROK, with Ct-J being the dominant clade. Our findings enhance current understanding of the genetic diversity within Cx. tritaeniorhynchus and provide valuable insights for the prevention of JEV outbreaks and the effective management of Cx. tritaeniorhynchus populations in East Asia.

Graphical Abstract
Mosquito breeding water parameters are important determinants for Microsporidia MB in the aquatic stages of Anopheles species
Authors: Akorli Esinam A. , Andoh Nana Efua , Egyirifa Richardson K. , Dorcoo Christopher , Otoo Sampson , Tetteh Seraphim N. A. , Pul Reuben Mwimson , Sackitey Derrick B. , Oware Stephen K. D. , Dadzie Samuel K. , Akorli Jewelna
Published: December 2024

Background

Microsporidia MB disrupts Plasmodium development in Anopheles mosquitoes, making it a possible biocontrol tool for malaria. As a tool for vector/disease control, its ecological distribution and the factors that determine their occurrence must be defined. We investigated the frequency of Microsporidia MB in Anopheles mosquitoes across selected sites in northern and southern Ghana, as well as the physicochemical parameters of mosquito breeding water that are associated with the occurrence of the fungus, by fitting regression models.

Methods

A non-column extraction method was used to extract DNA from the abdomens of 4255 adult Anopheles mosquitoes that emerged from larvae and pupae collected between August and October of 2021 and 2022. Detection of Microsporidia MB was achieved using quantitative PCR (qPCR), while mosquito species were molecularly identified using short interspersed nuclear elements (SINE), restriction fragment length polymorphism (RFLP) methods, and the ANOSPP algorithm.

Results

Overall Microsporidia MB distribution was 2.2% (92/4255). Male mosquitoes exhibited a higher frequency of infections and had a predicted probability of infection that was 85% higher than that of females. Sites in Ghana's Savannah zone had the highest Microsporidia MB distribution (68.5%). Biochemical oxygen demand in mosquito breeding water was estimated to be positively associated with and significantly predicts Microsporidia MB in mosquitoes with an accuracy of 94%. Increasing ammonium ion concentrations reduced the chances of finding Microsporidia MB-positive mosquitoes. According to our data, all Anopheles mosquitoes, including minor species such as An. squamosus, An. pretoriensis and An. rufipes, had equal probability of Microsporidia MB infection.

Conclusions

These results provide preliminary information on micro-ecological factors that potentially support the sustainability of Microsporidia MB infection in mosquitoes during their aquatic life stages. It will be important, therefore, to explore the impact of strategies for larval source management on these factors to ensure that the symbiont's persistence during the host's aquatic stages may not be adversely affected should it be used as an integrated approach for mosquito/disease control.

Graphical abstract
Effective use of dupilumab for eosinophilic gastritis concomitant with severe asthma
Authors: Takeshige Tomohito , Koyama Ryo , Motomura Hiroaki , Okajima Akifumi , Nishioki Toshihiko , Watanabe Junko , Yae Toshifumi , Kido Kenji , Takahashi Kazuhisa
Published: December 2024

Background

Eosinophilic gastrointestinal diseases (EGIDs) are chronic immune-mediated inflammatory disorders characterized by gastrointestinal symptoms and eosinophilic inflammation in specific regions of the gastrointestinal tract. “Eosinophilic gastritis” (EoG) refers to the condition in which the stomach is involved. In patients with EoG, approved treatment options are restricted despite the high mortality associated with the condition. Dupilumab is a human monoclonal antibody directed against the interleukin (IL)-4 receptor α subunit and inhibits the signaling pathways of both IL-4 and IL-13. The real-world data on the effectiveness of dupilumab for EoG are limited. We present the case of a patient with EoG and accompanying severe asthma who demonstrated improvement with dupilumab administration.

Case presentation

A 35-year-old woman who had been treated for asthma complained of worsening intermittent upper abdominal pain. Her dyspnea aggravated and she was admitted to our hospital for asthma exacerbation. Despite the improvement in her asthma symptoms with systemic corticosteroids, her abdominal pain persisted. Upper gastrointestinal endoscopic mucosal biopsy revealed eosinophilic cell infiltration; therefore, the patient was diagnosed with EoG. Dupilumab administration was initiated for asthma, while improvement of secondary EoG was expected. Following dupilumab administration, both EoG and asthma symptoms, disease control, laboratory findings, endoscopic findings, and pathological findings improved. No adverse events have been reported after the dupilumab treatment.

Conclusion

This case report supports that dupilumab could be an effective treatment option for EoG and accompanying severe asthma.
Factor structures and psychometric properties of three brief versions of the difficulties in emotion regulation scale in the Korean population
Authors: Kim Gyumyoung , Yim Minkyung , Bae Hayoung , Hur Ji-Won
Published: December 2024

Background

This study examined the latent factor structures and psychometric properties of three brief versions of the Difficulties in Emotion Regulation Scale (DERS)—DERS-SF, DERS-18, and DERS-16—across large-scale samples of the Korean population.

Methods

Participants from two independent community samples (N = 862 and N = 1,242) completed an online self-report survey, including brief versions of the DERS and associated measures. Confirmatory factor analyses were employed to examine the latent factor structures of the brief versions of the DERS with comparable models. The internal consistency, concurrent validity, and convergent validity of the brief versions of the DERS were also assessed.

Results

The findings revealed that the bifactor models of the DERS-SF and DERS-18, excluding the Awareness subscale, showed superior fit indices for latent factor structure and favorable reliability. By contrast, the DERS-16 exhibited inadequate fit. Scores from the DERS-SF and DERS-18 demonstrated significant associations with indicators of psychological distress, supporting their convergent validity. The Awareness subscale showed lower internal consistency and distinctive correlation patterns with clinical outcomes.

Conclusions

These findings highlight the robustness of the DERS-SF and DERS-18 as parsimonious and efficient measures of emotion dysregulation with fewer items than the original version. Furthermore, this study provides additional support for excluding the Awareness subscale when using the brief versions of the DERS.
Glacial lakes inventory and susceptibility assessment in the Alsek River Basin, Yukon, Canada
Authors: Kroczek Tomáš , Vilímek Vít
Published: December 2024

Background

This study investigates glacial lake outburst floods (GLOFs) within the Alsek River Basin, Yukon, Canada, a region experiencing accelerated glacier retreat due to climate change. The formation and expansion of glacial lakes pose significant hazards to geomorphological and ecological systems, even in the absence of human infrastructure. Despite extensive research in other glaciated regions such as the Himalayas and Andes, the Canadian Cordillera remains understudied. This research aims to inventory glacial lakes and assess their susceptibility to GLOFs using remote sensing techniques and two distinct methodologies.

Results

A total of 590 glacial lakes were identified, with 57 in direct or indirect contact with glaciers, warranting a detailed susceptibility assessment. The study applied the glacier-focused methodology of Wang et al. (Mt Res Dev 31(2):122 (2011). https://doi.org/10.1659/mrd-journal-d-10-00059.1) and the lakespecific dynamics approach of Khadka et al. (Front Earth Sci 8(January):1–16 (2021). https://doi.org/10.3389/feart.2020.601288). Key findings include: High-Hazard Lakes: Lakes 22, 23, 133, 134, and 275 were consistently identified as high-hazard due to factors such as large glacier inputs, steep moraine dams, and rapid expansion rates. GLOF Events: Four GLOF events were confirmed between 2017 and 2019, with the most significant reducing Lake 21's area by over 80%. Comparative Analysis: The integration of both methodologies provided a comprehensive understanding, revealing complementary insights into glacier-driven and lake-specific GLOF triggers.

Conclusion

The results underscore the critical role of glacier retreat and lake dynamics in driving GLOF hazards in the Alsek
River Basin. The study highlights the importance of combining multiple assessment methodologies for robust hazard evaluation. Given the dynamic nature of glacial lakes and ongoing climate change, continuous monitoring and proactive hazard management strategies are essential to mitigate potential geomorphological and ecological impacts. This research contributes to the broader understanding of GLOFs in North America and underscores the need for similar assessments in other understudied glaciated regions.
A study for the genotoxicity assessment of substances containing probiotic candidates in the in vitro TK6 cell micronucleus test: Influence of low pH conditions and antibiotic supplementation on the test results
Authors: Fujiishi Yohei , Ohyama Wakako , Okada Emiko
Published: December 2024

Background

When assessing the genotoxicity of substances containing probiotic candidates, such as lactic acid-producing bacteria, using the in vitro micronucleus test (MNT), bacterial growth in the test medium may reduce the pH of the medium. The low medium pH is known to induce cytotoxicity and false-positive results. In the TK6 cell system, it is difficult to completely remove the bacteria from the medium by washing post-treatment, leading to bacterial growth during the recovery period in the short-term treatment. In the present study, the low pH range yielding false positives in the TK6 cell MNT was investigated using media supplemented with acetic, lactic, or formic acids, which are non-genotoxic bacterial metabolites. Additionally, to suppress the bacterial growth during the recovery period using antibiotics, i.e., penicillin/streptomycin (P/S), gentamicin sulfate (GM), and amphotericin B (AP), the maximum applicable concentrations of them that did not affect TK6 cell growth or micronucleus induction were determined. Then, we conducted an MNT using a substance containing live lactic acid-producing bacteria to verify the effectiveness of the antibiotics.

Results

Acetic, lactic, and formic acids induced micronuclei in TK6 cells (false positive) at an initial pH of ≤ 6.2 and ≤ 6.0 in 3 h treatment with and without S9 mix, respectively, and of ≤ 6.7 in the continuous treatment. Media supplemented with P/S, GM, and AP did not affect TK6 cell growth or micronucleated cell frequencies in the negative and positive controls ≤ 400 unit/mL-400 µg/mL, ≤ 250, and ≤ 20 µg/mL, respectively. In an MNT with fermented milk containing live lactic acid-producing bacteria, supplementation with P/S or GM to media for the recovery cultures suppressed the bacterial growth, decreasing pH, and cytotoxicity.

Conclusion

This study revealed the low pH ranges yielding false positives in the TK6 cell MNT under short-term and continuous treatment conditions. These values will serve as references for interpreting the biological relevance of results. Under short-term treatment, optimal antibiotic supplementation in recovery cultures suppressed bacterial growth in the test substance and prevented the decrease in pH that could yield false positives. This approach might be useful for evaluating the genotoxicity of test substances containing probiotic candidates using the MNT.
Family history at the crossroads: reflections on past, present, and future challenges
Authors: Reher David Sven
Published: December 2024

This paper contains the reflections of the author on the state of family history within the constellation of History and the Social Sciences. The first part of the paper presents a brief outline of how the discipline was founded and the elements in play that contributed to its enormous initial success, especially visible during the last three decades of the twentieth century. In recent years, however, there is some indication that research output on family history has been in decline and, more important, appears to have lost a significant part of the luster it once had. In the second part of this paper the author looks at the importance of promoting a past–present dialogue on the family and the way both historians and social scientists understand it. Ways of strengthening interactions between family history and family studies are discussed, as is the crucial importance for the discipline of the data revolution currently underway that for the first time offers massive information about families around the world over the past six decades. The author argues that both historians and social scientists have much to say about family life during this relatively recent past, albeit from very different perspectives. Studying family change constitutes a key challenge for the field. We discuss different ways of approaching this issue in the recent past, as well as the advisability of looking at the concept of family systems more closely. In societies or regions where earlier more historical data exist (normally in the more developed world), it may also be possible to link existing historical results to those from the census microdata era in order to provide a new, long-term perspective on family life spanning two centuries or even more. For social scientists and family historians alike, understanding the key dimensions of change and their implications for society constitute a crucial challenge for the discipline.
Stroboscopy evaluation of vocal folds lesions with pre and post phono surgery
Authors: Eldemerdash Ahmed Mohamed , Behiery Essam Abd Elwanees , Rashad Asmaa El-Dessouky , Elghazali Mohamed Elshahat Abdoh , Eldemerdash Ashraf Ali
Published: December 2024

Background

Video laryngostroboscopy (VLS) is the most used method to visualize vocal fold vibration and mucosal wave assessment. It is used to evaluate the pliability of the vocal fold mucosa and is an indication of the health and function of the mucosal tissue and deeper layers. The aim of this work was to study the role of VLS in the evaluation of vocal fold lesions for deciding the best management plan and achieving the best post-operative voice results.

Methods

This prospective observational study was carried out on 70 patients aged more than 12 years, both sexes, with vocal fold (VF) lesions namely benign vocal fold lesions. Minimal associated pathological lesions (MAPLS) include VF nodules, VF polyps, and VF cysts.

Results

There was no significant difference between the micro flap, excision, and truncation technique regarding any of the post-procedure VLS assessments of the patients with bilateral VF nodules and unilateral VF polyp (p > 0.05). There was no significant difference between the micro flap technique, excision technique, or marsupialization technique regarding any of the Post-procedure VLS assessments of the patients with unilateral VF cysts (p > 0.05).

Conclusions

VLS provides a better guide for the phono surgeon to delineate the plane of dissection micro laryngeal surgery (MLS) which helps him in preserving the functional mucosa of the VF. This helps in achieving good voice quality and outcome after surgery. No significant difference between different surgical techniques used for their excision.
Amitriptyline–perphenazine therapy for persistent idiopathic facial pain: translational perspectives from a retrospective study
Authors: Marchesini Maurizio , Topi Giulia , Bonezzi Cesare , Demartini Laura
Published: December 2024

Background

Persistent idiopathic facial pain (PIFP) can be challenging, both in its diagnosis, which appears to be purely exclusionary, and in its treatment, which currently lacks a gold standard. Amitriptyline is considered a first-line therapy, although not always effective. Recent insights into the role of dopamine in facial pain suggest that a novel therapeutic approach could target the dopamine system.

Methods

This study aimed to retrospectively evaluate the efficacy of treatment with amitriptyline–perphenazine association in patients with severe PIFP. Thirty-one patients were given a regimen dose of amitriptyline–perphenazine at dosages ranging between 10/2 and 20/4 mg and were then retrospectively analyzed. We evaluated the following outcomes, referred to the last week prior to follow-up visits: NRS score for pain intensity (minimum, maximum, and average), the number of attacks, and SF-36 questionnaire for quality of life. Comparisons were made between pre- and post-treatment.

Results

Thirty-one patients over 35 were screened. At baseline, average NRS was 5 ± 0.93 (CI 95%: 4.6–5.3), and the median number of breakthrough episodes over last week was 5 ± 1.57 (CI 95%: 4–6) with a maximum NRS = 9 ± 0.89 (CI 95%: 8–9). After treatment, average NRS was 4.1 ± 0.93 (CI 95%: 3.8–4.5; p < 0.001), maximum NRS was 6.1 ± 1.60 (CI 95%: 5.5–6.6), and the median number of attacks was 4 ± 0.99 (IC 95%: 3–4) (p < 0.001). Regarding SF-36 questionnaire, the most improved parameters were quality of life related to pain (25.89 ± 12.48 vs 31.19 ± 13.44; p < 0.001) and physical function (69.56 ± 17.84 vs 84.17 ± 20.99; p < 0.001).

Conclusion

Despite limitations, the pain scores, the frequency of the attacks, and quality of life were found to be significantly improved after treatment. Although results are not broad based given the small sample size, the combination of amitriptyline and perphenazine may be an effective and well-tolerated treatment in patients with PIFP. It is abundantly clear that dopaminergic pathways play a key role in pain modulation, yet the underlying mechanisms have not been fully understood, requiring further investigation.
Seismic Foundation Model (SFM): a next generation deep learning model in geophysics
Authors: Sheng Hanlin , Wu Xinming , Si Xu , Li Jintao , Zhang Sibo , Duan Xudong
Published: December 2024

While computer science has seen remarkable advancements in foundation models, they remain underexplored in geoscience. Addressing this gap, we introduce a workflow to develop geophysical foundation models, including data preparation, model pre-training, and adaption to downstream tasks. From 192 globally collected 3-D seismic volumes, we create a carefully curated dataset of 2,286,422 2-D seismic images. Fully using these unlabeled images, we employ the self-supervised learning to pre-train a Transformer-based Seismic Foundation Model (SFM) for producing all-purpose seismic features that work across various tasks and surveys. Through experiments on seismic facies classification, geobody identification, interpolation, denoising, and inversion, our pre-trained model demonstrates versatility, generalization, scalability, and superior performance over baseline models. In conclusion, we provide a foundation model and vast dataset to advance AI in geophysics, addressing challenges (poor generalization, lacking labels, and repetitive training for task-specified models) of applying AI in geophysics and paving the way for future innovations in geoscience.
Abemaciclib Plus Fulvestrant in Advanced Breast Cancer After Progression on CDK4/6 Inhibition: Results From the Phase III postMONARCH Trial
Authors: Kalinsky Kevin , Bianchini Giampaolo , Hamilton Erika , Graff Stephanie L. , Park Kyong Hwa , Jeselsohn Rinath , Demirci Umut , Martin Miguel , Layman Rachel M. , Hurvitz Sara A. , Sammons Sarah , Kaufman Peter A. , Muñoz Montserrat , Lai Jiun-I , Knoderer Holly , Sandoval Cynthia , Chawla Aarti R. , Nguyen Bastien , Zhou Yanhong , Ravenberg Elizabeth , Litchfield Lacey M. , Smyth Lillian , Wander Seth A.
Published: December 2024

PURPOSE

Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) combined with endocrine therapy (ET) are the standard first-line treatment for hormone receptor–positive (HR+), human epidermal growth factor receptor 2–negative (HER2–) advanced breast cancer (ABC); however, disease progression occurs in almost all patients and additional treatment options are needed. Herein, we report outcomes of the postMONARCH trial investigating a switch in ET with/without CDK4/6 inhibition with abemaciclib after disease progression on CDK4/6i.

METHODS

This double-blind, randomized phase III study enrolled patients with disease progression on previous CDK4/6i plus aromatase inhibitor as initial therapy for advanced disease or recurrence on/after adjuvant CDK4/6i + ET. Patients were randomly assigned (1:1) to abemaciclib + fulvestrant or placebo + fulvestrant. The primary end point was investigator-assessed progression-free survival (PFS). Secondary end points included PFS by blinded independent central review, objective response rate (ORR), and safety.

RESULTS

This study randomly assigned 368 patients (abemaciclib + fulvestrant, n = 182 placebo + fulvestrant, n = 186). At the primary analysis (258 events), the hazard ratio (HR) was 0.73 (95% CI, 0.57 to 0.95; nominal
P
= .017), with median PFS 6.0 (95% CI, 5.6 to 8.6) versus 5.3 (95% CI, 3.7 to 5.6) months and 6-month PFS rates of 50% and 37% in the abemaciclib + fulvestrant and placebo + fulvestrant arms, respectively. These results were supported by BICR-assessed PFS (HR, 0.55 [95% CI, 0.39 to 0.77]; nominal
P
< .001). A consistent treatment effect was seen across major clinical and genomic subgroups, including with/without
ESR1
or
PIK3CA
mutations. Among patients with measurable disease, investigator-assessed ORR was improved with abemaciclib + fulvestrant versus placebo + fulvestrant (17%
v
7%; nominal
P
= .015). No new safety signals were observed, with findings consistent with the known safety profile of abemaciclib.

CONCLUSION

Abemaciclib + fulvestrant significantly improved PFS after disease progression on previous CDK4/6i + ET in patients with HR+, HER2– ABC, offering an additional targeted therapy option for these patients.
Ecological Utopia and Dystopia in Chinese Science Fiction
Authors: Wang Ban
Published: December 2024

Crossing the binary of utopia and dystopia, this article reads Hao Jingfang's (1984–) novel Vagabonds as a critical ecotopia. I explore configurations of social worlds and eschew the politics of purity by highlighting the complexities of building a utopia while navigating entangled complicity and ambiguity between utopia and dystopia. The Mars Republic in the novel represents an ecotopia built through advanced technologies, where Martians adapt to the arid environment in contrast with the environmentally degraded earth. The novel portrays encounters, shocks, and mutual critiques between two planets. In general, the novel articulates the multicultural and multiracialism on Mars and the coming-of-age narrative of young Martians. Their self-realization rests on the assumption that humans must engage with and appropriate from nature while changing their inner nature.
Ο ποιητικός και εικαστικός ζωομορφισμός
Authors: Κωστούλα-Καρατζά Βασιλική
Published: December 2024

Σκοπός της ανά χείρας διατριβής είναι να μελετηθούν τα δίκτυα συνάφειας μεταξύ του ποιητικού έργου του Σαχτούρη και του ζωγραφικού του Chagall στη βάση αφενός των συγκριτολογικών παραμέτρων της αναλογίας, της σημειωτικής αφετέρου προσέγγισης λογοτεχνίας και ζωγραφικής. Η προσέγγισή μας επικεντρώνεται ως εκ τούτου στη σύγκλιση λόγου και εικόνας, ρηματικών/ποιητικών δηλαδή και εικαστικών/ζωγραφικών πραγματώσεων, στο ποιητικό και ζωγραφικό έργο του Σαχτούρη και του Chagall αντίστοιχα· έργο που συντάσσεται με και αξιοποιεί τις κατακτήσεις του Μοντερνισμού, ιδιαίτερα δε εκείνες των κινημάτων της μοντερνιστικής πρωτοπορίας του Υπερρεαλισμού και Εξπρεσιονισμού. Βάσει των παραπάνω, προχωρούμε στην κειμενοκεντρική ανάλυση των συνεξεταζόμενων έργων με άξονα αναφοράς την εννοιολογική κατηγορία του ζωομορφισμού σε τρεις εκδοχές του, στις υβριδικές, στις μεταστοιχειωμένες και τις αντεστραμμένες μορφές, χωροθετημένες στα όρια του επίγειου και του ουράνιου κόσμου. Έτσι, ποίηση και ζωγραφική, δύο καλλιτεχνικά ιδιώματα, το καθένα με την ιδιαίτερη τροπολογία του, μορφοποιούν υβριδικούς, μεταστοιχειωμένους και αντεστραμμένους όγκους, αναδεικνύοντας αφηγηματικά και εικαστικά έναν κόσμο ανοικειωτικό, επιμερισμένο σε πολλαπλές αποτροπαϊκές μορφές του Κακού, και χαράσσοντας οδούς λυτρωτικής εξόδου. Η έρευνά μας, λοιπόν, επικεντρωμένη στον ποιητικό λόγο, που μπορεί να οπτικοποιεί και τον εικαστικό να αφηγείται παραστατικά ή υπαινικτικά, επιχείρησε να αναδείξει ενδιαφέρουσες από ερμηνευτική άποψη συγκλίσεις μεταξύ του ποιητικού έργου του Σαχτούρη και του ζωγραφικού του Chagall, και να διανοίξει μια νέα προοπτική στη μελέτη της ποίησης και της ποιητικής του Σαχτούρη.
Studying the main characteristics of the Geminid meteor shower from baseline video observations in 2021
Authors: Ivanov Kirill , Komarova Evgeniya , Yazev Sergey
Published: December 2024

The Geminid meteor shower has been studied using data obtained by the method of baseline video observations during the period from December 01, 2021 to December 17, 2021. The meteors were examined in the brightness range from –3m to 2m and with an angular track length of at least 2°; the sample size was 327 events. The behavior of the shower is considered in terms of the interacting DRG (December ρ-Geminids) and GEM (Geminids) branches, which are closely related to each other and share a common origin. The shower activity was ZHR=127, Flux=19 at the general maximum of DRG+GEM (λsol~261.8°) and ZHR=32, Flux=4 at the putative local maximum of DRG (λsol~258.8°). Daily drift values were obtained for GEM (Δα=0.84°, Δδ=–0.27°, Δλec=0.75°, Δβ=–1.17°) and DRG (Δα=1.29°, Δδ=0.09°, Δλec=1.09°, Δβ=0.23°) in the equatorial and ecliptic coordinate systems; the intrinsic drift in the λec–λsol system was 0.09° and –0.26° for the DRG and GEM components respectively. We have found the opposite nature of the drift of both branches with a tendency for them to intersect at the point α=112.1°, δ=32.5°, λsol=259.8°. We have determined the kinematic and orbital parameters of meteoroids and have identified differences between the most probable geocentric velocities for the DRG (vg=35 km/s) and GEM (vg=34 km/s) branches. The morphology of the distribution of orbits within the plume has been studied. We give recommendations for reliably determining whether the meteors belong to one or another branch.
'Be You Never So Gaye': A Queer Everyman
Authors: Irvin Matthew W.
Published: December 2024

The late medieval play Everyman might seem to exclude queerness, but its religious challenge to secular temporality is the very place to find the queer body of the past. Using Giorgio Agamben’s concept of ‘messianic time’ and queer theoretical interventions by Michel Foucault, J. Halberstam, and José Esteban Muñoz, this paper argues that Everyman creates a time for friendship as a way of life. That time is a ‘gaye’ time; though the theology of the play may foreclose that time of fellowship and pleasure, the performance of the play produces a time outside the grip of theological order.
Explorando el Impuesto sobre la renta de Sociedades en el Aula: Una Perspectiva desde los Ciclos de Mejora (CIMA)
Authors: Dugo Domínguez Víctor Jesús
Published: December 2024

El Ciclo de Mejora en el Aula (CIMA) implementado en la asignatura de Sector Público, dirigida a estudiantes en el segundo curso de Administración y Dirección de Empresas, se revela como una experiencia educativa transformadora. A lo
largo de las sesiones, se adoptó un enfoque participativo y colaborativo que superó la reticencia inicial de los alumnos, logrando una elevada participación en
debates y actividades. El uso de mapas de contenidos proporcionó una estructura visual clara, respaldando un modelo metodológico que incorpora las ideas
de los alumnos y actividades de contraste. El aprendizaje se centró en cuestiones
clave relacionadas con el Impuesto sobre la Renta de Sociedades. Se programaron acciones para evaluar y verificar resultados mediante cuestionarios iniciales y
finales, evidenciando la mejora sustancial en el conocimiento de los estudiantes.
A pesar de desafíos y fluctuaciones emocionales del docente, la evolución positiva de los estudiantes se refleja en la retroalimentación positiva, respaldando la
efectividad del CIMA. Se destaca la importancia de mantener y mejorar esta metodología en futuras implementaciones
Ciclo de Mejora en el Aula en Historia, Teoría y Métodos de la Enfermería I: Enfoque de Aprendizaje Práctico
Authors: Torrejón-Guirado María-Carmen
Published: December 2024

Se ha implementado un ciclo de mejora en el aula (CIMA) en la asignatura de
Historia, Teoría y Métodos de la Enfermería I del primer curso del Grado de Enfermería. Este CIMA se realizó en sesiones de trabajo de grupos reducidos (seminarios) con el objetivo de fomentar la practicidad de las clases y con ella, la
participación de los estudiantes mediante la incorporación de trabajo colaborativo, resolución de casos y simulación clínica. Se evaluó el aprendizaje del grupo,
donde los resultados indicaron una mejora del aprendizaje del alumnado con las
nuevas técnicas incorporadas.
Nivel de red: ¿cómo se comunica tu ordenador con los servidores del League of Legends (LoL)?
Authors: Castro García Juan Antonio
Published: December 2024

Se ha realizado un Ciclo de Mejora en el Aula (CIMA) de 8 horas enmarcado
en el tema 4 de la asignatura de Redes de Computadores de segundo curso del
Grado de Ingeniería Informática–Ingeniería del Software, que versa sobre el nivel de red. El diseño del CIMA está sustentado en las competencias generales, específicas y básicas del programa de la asignatura. Además, se incluye el mapa de
contenidos, la secuencia de actividades, que incluye un juego interactivo para
favorecer la comprensión de conceptos, y la evaluación del aprendizaje de los
alumnos.
Evaluación de un Ciclo de Mejora en la asignatura Ciencia y Tecnología del Medio Ambiente
Authors: Morillas Viñuales Lourdes
Published: December 2024

En este trabajo se evalúa la aplicación de un Ciclo de Mejora en el Aula (CIMA)
en la asignatura Ciencia y Tecnología del Medio Ambiente que se imparte en el
segundo curso del grado de Ingeniería Agrícola de la Universidad de Sevilla. Las
actividades asociadas al CIMA se han realizado en el marco de los temas nutrientes minerales y la materia orgánica en el suelo y su descomposición. La valoración del estudiantado del CIMA ha sido positiva y han resaltado explícitamente
su satisfacción con el cambio docente. Sin embargo, los resultados de la evaluación del aprendizaje del estudiantado no han sido tan satisfactorio como se podría haber esperado y se han identificado algunos puntos en los que hay margen
de mejora. La baja asistencia a clase, escasa participación del alumnado y la corta
duración de las sesiones (55 minutos) han limitado el éxito de este CIMA. Por otro
lado, los resultados sugieren que dedicar más tiempo a realizar actividades de
contraste y modificar el planteamiento de las preguntas de los cuestionarios iniciales y finales, podrían mejorar el aprendizaje del estudiantado.
Aplicación de un Ciclo de Mejora e Innovación en Aula de la asignatura Materiales Funcionales
Authors: Bautista Bautista Miguel Antonio
Published: December 2024

Para este capítulo se realizó un Ciclo de Mejora en el Aula en la asignatura
Materiales Funcionales del grado en ingeniería de tecnologías industriales, en el
cual se incorporan nuevas actividades en la dinámica de Enseñanza-Aprendizaje.
Se añaden como novedad en el proceso, ideas de alumnos y actividades de contraste en los temas de propiedades ópticas y propiedades térmicas del temario.
Luego de analizados los logros de los estudiantes al final de este ciclo de mejora,
se nota a través del análisis de las encuestas iniciales y finales que han aprovechado esta nueva metodología valorándola de forma positiva y evidenciándose
claramente como su conocimiento aumenta casi de forma autónoma.
Trabajando la entrevista. Aplicación de un Ciclo de Mejora en el Aula en Evaluación Psicológica
Authors: Rosales Becerra Angela Mª
Published: December 2024

El objetivo del presente trabajo es mostrar los resultados de la aplicación de
un Ciclo de Mejora en el Aula en la asignatura de Evaluación Psicológica que se
imparte en tercer curso del Grado de Psicología. La propuesta se desarrolló en un
grupo bilingüe donde se impartieron clases teóricas. Se pretendía que los alumnos participaran activamente en la construcción de su conocimiento., trabajaran su creatividad y se reforzara la conexión entre los contenidos teóricos y la
práctica real. El modelo didáctico se basó en las características de la metodología colaborativa y de investigación-acción. Los contenidos de organizaron alrededor de una serie de preguntas vinculadas a actividades de contraste. Se diseñó
un cuestionario basado en los problemas que se iban a trabajar y se realizó una
aplicación previa y posterior a la impartición del tema. Los resultados obtenidos
indican que este Ciclo de Mejora ha generado cambios en los modelos mentales
de los alumnos.
Descubriendo la Discapacidad Intelectual a lo largo de la vida: Una experiencia de innovación docente en el Grado en Psicología
Authors: Ciria Barreiro Esther
Published: December 2024

La innovación docente permite analizar los factores que explican los procesos de enseñanza y aprendizaje, con el objetivo de aplicar dichos conocimientos
para mejorar la experiencia educativa del alumnado. En este trabajo se diseñó e
implementó un Ciclo de Mejora en el Aula (CIMA) en la asignatura Trastornos en
el Desarrollo en el Grado en Psicología de la Universidad de Sevilla. El tema elegido fue el estudio del ciclo vital de las personas con Discapacidad Intelectual. Se
emplearon diversas actividades que fomentaban la participación del alumnado,
tanto de manera individual como grupal. Se evaluó la evolución de las ideas del
alumnado a través de un cuestionario pre-post. Los resultados fueron mixtos, evidenciando que el CIMA facilitó el desarrollo de conocimientos, actitudes y procedimientos del alumnado en algunas áreas y competencias. Se reflexiona en este
trabajo sobre el alcance de la implementación de este tipo de actividades y sobre
los aspectos claves que permiten ofrecer una docencia de mejor calidad.
Innovación en la metodología docente adaptada a la Química General
Authors: Carrasco Carrasco Carlos Jesús
Published: December 2024

En el trabajo que se describe a continuación se detallan los resultados obtenidos tras la implementación de un Ciclo de Mejora en el Aula (CIMA) en los seminarios de la asignatura Química I, impartida en el primer cuatrimestre del Grado
en Ingeniería de Materiales / Doble grado en Física e Ingeniería de Materiales de
la Facultad de Física durante el curso 2023/24. Concretamente, en dicha asignatura, se muestran conocimientos generales sobre la Química que actúan como
base durante el trayecto educativo/académico del estudiante. La finalidad de dicho CIMA se centra en ayudar al alumnado a encontrar su propia capacidad autodidacta usando los conocimientos del profesorado como apoyo.
FROM PAST TO PRESENT: A SOCIOCULTURAL PERSPECTIVE ON JEWS OF URFA
Authors: Şanlı Süleyman
Published: December 2024

ABSTRACT: The expulsion from Spain led to the Ottoman State becoming a peaceful refuge for Jewish communities. Over time, Ottoman Jewry evolved into one of the most culturally diverse religious minority groups and was widely dispersed throughout the State. Additionally, Jewish communities thrived in various Arab provinces and different regions of Anatolia. Notably, there were ancient Jewish settlements in the eastern part of the initial Ottoman State, which later became Turkey. The Jewish community of Urfa, residing in the eastern part of the country, was one of the oldest religious minority groups in the region.
This study aims to thoroughly examine the historical background, social and cultural relationships, and the migration process of the Urfa Jewish Community, which transitioned from the eastern region of Turkey to settle in Israel. Furthermore, the study seeks to shed light on aspects of their lifestyle, religious beliefs, and interactions with other local groups and cultures within the multicultural environment of Urfa. This research has entailed anthropological fieldwork conducted in Israel between the years 2011-2012, with a focus on a socio-cultural perspective. Ultimately, the objective is to elevate the visibility of these historically overlooked local people of Urfa and bring attention to their unique cultural heritage within the academic discourse.
Keywords: Jews, Ethnography, Urfa, Culture, Migration, Memory
Homozygous phytosterolemia and a literature review: A case report
Authors: Jiang Chun-Xin , Yang Guang , Shi Lian-Ping , Su Peng-Yu
Published: December 2024

BACKGROUND

Phytosterolemia, also known as sitosterolemia, is a rare autosomal recessive disease characterized by elevated plasma plant sterol levels and xanthomata, which is easily misdiagnosed as familial hypercholesterolemia. Patients with homozygous phytosterolemia often have severe clinical manifestations, with xanthomata in childhood and premature atherosclerosis. Our patient had a milder clinical phenotype.

CASE SUMMARY

This report describes a patient with homozygous phytosterolemia who presented with only elevated cholesterol and low-density lipoprotein cholesterol (LDL-C) without xanthomata, arteriosclerosis, or hematological abnormalities. Homozygous mutation of ABCG5 which encodes an ATP-binding cassette transporter, was detected by whole exome sequencing and diagnosed as phytosterolemia. Measurement of the patient’s plasma plant sterol levels detected significant elevations in stigmasterol, rapeseed oil-derived plant sterol, and β-glutaminol levels. Ezetimibe was started and a low plant sterol diet was recommended. The patient’s blood lipid profile was reexamined one month later and showed significant decreases in total cholesterol and LDL-C levels. Phytosterolemia has similar clinical features as familial hypercholesterolemia, is highly susceptible to misdiagnosis, and has a very low incidence, and therefore clinicians need to consider a genetic diagnosis of a definitively hyperlipidemic disorder when statin drugs fail to lower lipid levels.

CONCLUSION

Phytosterolemia is easily misdiagnosed as familial hypercholesterolaemia and can be treated by dietary modification and cholesterol absorption inhibitors to lower blood lipids.
The Cuban state enterprise in its labyrinth: Conceptualisations, measures, and changes to be made
Authors: Rosales Humberto Blanco
Published: December 2024

The work assesses this economic actor in the programmatic documents of the last three Party Congresses. It starts with some data that characterise the Cuban entrepreneurial system at the end of 2023. After this, it very briefly looks at the document Economic and Social Guidelines of the Party and the Revolution (hereafter, Guidelines) that came out of the VI Party Congress, the foundational document of the so-called process of updating the Cuban economic model.

The next two sections open with a balance of the contributions and limitations of the Conceptualization of the Cuban Economic and Social Model of Socialist Development (hereafter Conceptualization) related to state-owned enterprises. Subsequently, other documents related to the ‘implementation’ of the Conceptualization are discussed. Finally it includes some ideas, the result of collective work, for transforming the management and the performance of this economic actor, in the midst of a critical situation that requires increasing the country’s entrepreneurial capacity, stabilising the macroeconomy, and embarking on the necessary and difficult path towards a productive reconstruction.
Sub-20-fs Kerr-lens mode-locked Yb:Sr3Y2(BO3)4 laser
Authors: Zeng Huang-Jun , Nie Hai-Yu , Lin Zhang-Lang , Zhang Ge , Lin Zhoubin , Sun Shijia , Teng Bing , Liang Hsing-Chih , Loiko Pavel , Mateos Xavier , Petrov Valentin , Chen Weidong
Published: December 2024

We report on a diode-pumped Kerr-lens mode-locked Yb:Sr3Y2(BO3)4 laser generating soliton pulses as short as 19 fs at 1073.1 nm with an average output power of 131 mW at ~74.1 MHz.
Optimization of nanosecond pulse energy extraction from Tm3+-doped photonic crystal fibers
Authors: Schneider Julian , Lorenz Dominik , Lautenschläger Jan , Romano Clément , Eichhorn Marc , Kieleck Christelle
Published: December 2024

This study discusses the limitations for pulse energy extraction in nanosecond-pulsed rare-earth-doped fiber lasers. Optimization of the fiber length considering reabsorption effects leads to the demonstration of pulse energies of 1.9 mJ at an average output power of 114 W and an emission wavelength of 2050 nm from a Tm3+-doped flexible photonic crystal fiber.
Highly-efficient Tm:LiYF4 Waveguide Laser Passively Q-switched by Carbon Nanotubes
Authors: Bae Ji Eun , Loiko Pavel , Rotermund Fabian , Brasse Gurvan , Braud Alain , Camy Patrice
Published: December 2024

A Tm:LiYF4 diamond-saw-diced channel waveguide laser passively Q-switched by a single-walled carbon nanotube saturable absorber delivers 1.30 W at 1885 nm with a slope efficiency of 64.2% emitting 45-ns/0.87-μJ pulses at 1.50-MHz repetition rate.
Highly Compact Stable-Unstable Tm:LLF Thin-Slab Resonator
Authors: Sanwell Jake , Groult Lucas , Carter Richard M , Esser M J Daniel
Published: December 2024

A compact hybrid stable-unstable Tm:LLF thin-slab laser is demonstrated utilising toroidal mirrors, with estimated M2 of 1.6 and 3.3 in minor and major axes, and over 30 times greater brightness than an equivalent stable resonator.
Efficient Reconstruction of the Temporal Profile of GW-scale Isolated Attosecond Pulses by All-optical FROG
Authors: Dong Dianhong , Wang Hushan , Imasaka Kotaro , Kanda Natsuki , Takahashi Eiji J.
Published: December 2024

The intense isolated attosecond pulses are characterized by an efficient and convenient all-optical FROG method, demonstrating pulse durations of ~227 as and ~148 as with central photon energies at 60 eV and 107 eV, respectively.
Multi-Watt 2.3-µm Tm:YLF Laser Based on an Off-Resonance Intracavity Upconversion Pumping Scheme
Authors: Glasset Matthieu , Dupont Hippolyte , Guillemot Lauren , Loiko Pavel , Camy Patrice , Georges Patrick , Druon Frédéric
Published: December 2024

An innovative off-resonance Tm upconversion intracavity pumping scheme at 1064 nm is demonstrated employing a Tm:YLF/Nd:YVO4 laser. The 2.3-µm Tm-laser delivers 2.71 W for 20.4 W of diode-pump power, being competitive with direct diode pumping.
Thermally-induced depolarization compensation for the ’Bivoj’ DiPole 100J @ 10 Hz system
Authors: Jochcová Dominika , Slezák Ondřej
Published: December 2024

Development in thermal-stress-induced birefringence compensation in complex laser systems by means of Mueller-matrix polarimetry introduces analytical alternative to four-parameter numerical approach. Validated on Bivoj/DiPOLE100 data, it offers deeper insight and faster suppression of power losses.
Coherent combining of large-beam high-energy Nd:glass laser amplifier in a Sagnac-interferometer configuration
Authors: Lebegue Pierre , De Sousa Joanna , Rapeneau Cyril , Badarau Doina , Andrieu Jordan , Audebert Patrick , Druon Frédéric , Papadopoulos Dimitris N.
Published: December 2024

We present, coherent combining of two 10-Joules nanosecond pulses in a Sagnac-interferometer configuration including large-diameter Nd:glass flash-pumped amplifiers. A good stability between the shots and an average efficiency of 92 % is demonstrated.
Polarized Spectroscopy of Er:CALGO for 2.8 μm Lasers
Authors: Cassouret Florent , Normani Simone , Loiko Pavel , Pan Zhongben , Giordano Luidgi , Viana Bruno , Chen Weidong , Camy Patrice
Published: December 2024

We report on polarization-resolved spectroscopy and excited-state dynamics of Er3+ ions in CALGO highlighting its potential for mid-infrared lasers. The stimulated-emission cross-section is 2.63×10-20 cm2 at 2730 nm for π-polarization (emission bandwidth: 28 nm).
Er:CaF2 Crystal and Laser Ceramic: a Comparative Study
Authors: Normani Simone , Loiko Pavel , Gan Shiyan , Li Weiwei , Mei Bingchu , Benayad Abdelmjid , Jambunathan Venkatesan , Braud Alain , Chen Weidong , Camy Patrice
Published: December 2024

Spectroscopy and mid-infrared laser performance are compared for Er:CaF2 single-crystal and hot-pressed transparent ceramic. The 2.8-µm Er:CaF2 crystal laser delivers 0.81 W with 32.6% slope efficiency and outperforms the ceramic due to enhanced ion clustering.
Eliminating Discrepancies in Er3+:YLF Emission Cross-Sections at ~3µm
Authors: Ter-Gabrielyan Nikolay , Fromzel Viktor , Dubinskii Mark
Published: December 2024

Comprehensive study of spectral kinetics of a free-running, pulsed, ~3-µm Er:YLF laser versus Er3+ concentration, pump energy and temperature eliminates discrepancy in existing data on emission cross-sections of inter-Stark transitions between the
4
I
11/2
and
4
I
13/2
manifolds.
In-band pumped Ho:KLu(WO4)2 laser
Authors: Slimi Sami , Mateos Xavier , Solé Rosa Maria , Aguiló Magdalena , Díaz Francesc , Chen Weidong , Loiko Pavel , Chen Cui , Griebner Uwe , Petrov Valentin
Published: December 2024

Multi-Watt continuous-wave operation is reported for the first time for an in-band pumped Ho:KLu(W)4)2 laser emitting at 2078 nm in Nm polarization.
Ultrafast laser system with record GHz repetition rate in burst mode from all single-mode fiber
Authors: Laçin Mesut , Repgen Paul , Maghsoudi Amirhossein , İlday Fatih Ömer
Published: December 2024

We present a novel laser system integrated within strictly single-mode fibers, capable of generating bursts of 100-fs pulses at a 50 GHz repetition rate with an average power of 100 W. This configuration facilitates highly efficient and precise material processing in the ablation-cooled regime.