bluuebunny/crossref_metadata_2025 huggingface dataset:
Risk factors of amyotrophic lateral sclerosis: a global meta-summary
Authors: Duan Qing-Qing , Jiang Zheng , Su Wei-Ming , Gu Xiao-Jing , Wang Han , Cheng Yang-Fan , Cao Bei , Gao Xia , Wang Yi , Chen Yong-Ping
Published: April 2023

Background

The etiology of amyotrophic lateral sclerosis (ALS) remains largely unknown. This study aimed to summarize the relationship between ALS and its genetic and non-genetic risk factors.

Method

A search of relevant literature from PubMed, Embase, and Cochrane Database from inception to December 2022 was performed. Random-effects or fixed-effects models were performed by Stata MP 15.0 to pool multivariate or adjusted ratios (OR). PROSPERO registration number: CRD42022301549.

Results

230 eligible studies were included, of which 67 involved 22 non-genetic factors, and 163 involved genetic factors. Four aspects of non-genetic factors, including lifestyle, environmental and occupational exposures, pre-existing diseases/comorbidity and medical exposures, and others, were analyzed. Exposure to heavy metals (OR = 1.79), pesticides (OR = 1.46), solvents (OR = 1.37), previous head trauma (OR = 1.37), military service (OR = 1.29), stroke (OR = 1.26), magnetic field (OR = 1.22) and hypertension (OR = 1.04) are significant risk factors, but use of antidiabetics (OR = 0.52), high BMI (OR = 0.60 for obese and overweight vs. normal and underweight), living in urban (OR = 0.70), diabetes mellitus (OR = 0.83), and kidney disease (OR = 0.84) decrease the risk for ALS. In addition, eight common ALS-related genes were evaluated, the mutation frequencies of these genes were ranked from highest to lowest as SOD1 (2.2%), C9orf72 (2.1%), ATXN2 (1.7%), FUS (1.7%), TARDBP (0.8%), VCP (0.6%), UBQLN2(0.6%) and SQSTM1 (0.6%) in all the ALS patients.

Conclusions

Our findings suggested that effective intervention for risk exposure and timely modification of lifestyle might prevent the occurrence of ALS. Genetic mutations are important risk factors for ALS and it is essential to detect genetic mutations correctly and scientifically.

Systematic review registration

https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=301549, identifier: CRD42022301549.
Common mechanisms underlying axonal transport deficits in neurodegenerative diseases: a mini review
Authors: Yang Xiaoman , Ma Zhuoran , Lian Piaopiao , Xu Yan , Cao Xuebing
Published: April 2023

Many neurodegenerative diseases including Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis are characterized by the accumulation of pathogenic proteins and abnormal localization of organelles. These pathological features may be related to axonal transport deficits in neurons, which lead to failures in pathological protein targeting to specific sites for degradation and organelle transportation to designated areas needed for normal physiological functioning. Axonal transport deficits are most likely early pathological events in such diseases and gradually lead to the loss of axonal integrity and other degenerative changes. In this review, we investigated reports of mechanisms underlying the development of axonal transport deficits in a variety of common neurodegenerative diseases, such as Alzheimer’s disease, amyotrophic lateral sclerosis, Parkinson’s disease and Huntington’s disease to provide new ideas for therapeutic targets that may be used early in the disease process. The mechanisms can be summarized as follows: (1) motor protein changes including expression levels and post-translational modification alteration; (2) changes in microtubules including reducing stability and disrupting tracks; (3) changes in cargoes including diminished binding to motor proteins. Future studies should determine which axonal transport defects are disease-specific and whether they are suitable therapeutic targets in neurodegenerative diseases.
Healthy adults supplemented with a nutraceutical formulation containing Aloe vera gel, rosemary and Poria cocos enhances the effect of influenza vaccination in a randomized, triple-blind, placebo-controlled trial
Authors: Lewis Erin D. , Crowley David C. , Guthrie Najla , Evans Malkanthi
Published: April 2023

The study objective was to examine the role of a formulation, UP360, containing rosemary and Poria cocos extracts and Aloe vera gel powder, in healthy adults on supporting immune function with influenza vaccination. A 56-day randomized, triple-blind, placebo-controlled, parallel study consisted of a 28-day pre-vaccination period, an influenza vaccination on Day 28 and a 28-day post-vaccination period. Men and women ages 40–80 who had not yet been vaccinated for the flu were randomized to UP360 or Placebo (n = 25/group). At baseline, Days 28 and 56, blood lymphocyte populations, immunoglobulins (Ig), and cytokines were measured, and quality of life (QoL) questionnaires administered. The Wisconsin Upper Respiratory Symptom Survey (WURSS)-24 was completed daily by participants to measure incidence of upper respiratory tract infection (URTIs). In the post-vaccination period, TCR gamma-delta (γδ+) cells, known as γδ T cells, increased with UP360 supplementation compared to Placebo (p < 0.001). The UP360 group had a 15.6% increase in influenza B-specific IgG levels in the post-vaccination period (p = 0.0006). UP360 significantly increased the amount of circulating glutathione peroxidase (GSH-Px) from baseline at Day 28 (p = 0.0214), an enzyme that is important for neutralizing free radicals. While UP360 supplementation initially decreased levels of anti-inflammatory cytokine IL-1RA in the pre-vaccination period, IL-1RA levels were increased in the post-vaccination period (p ≤ 0.0482). Levels of IL-7 increased from baseline at Day 56 with UP360 supplementation (p = 0.0458). Despite these changes in immune markers, there were no differences in URTI symptoms or QoL between UP360 and Placebo. These results suggest UP360 supplementation was beneficial in eliciting a healthy, robust immune response in the context of vaccination. No changes in subjective measures of URTI illness or QoL demonstrated that participants’ QoL was not negatively impacted by UP360 supplementation. There were no differences in clinical chemistry, vitals or adverse events confirming the good safety profile of UP360. The trial was registered on the International Clinical Trials Registry Platform (ISRCTN15838713).
Selection of endogenous control and identification of significant microRNA deregulations in cervical cancer
Authors: Stverakova T. , Baranova I. , Mikyskova P. , Gajdosova B. , Vosmikova H. , Laco J. , Palicka V. , Parova H.
Published: April 2023

Introduction

Cervical cancer causes approximately 350,000 deaths each year. The availability of sensitive and specific diagnostic tests to detect cervical cancer in its early stages is essential to improve survival rates.

Methods

In this study, we compared two strategies for selecting endogenous controls: miRNA profiling by small-RNA sequencing and a commercially available microfluidic card with 30 recommended endogenous controls preloaded by the manufacturer. We used the RefFinder algorithm and coefficient of variation to select endogenous controls. We selected the combination of miR-181a-5p and miR-423-3p as the most optimal normalizer. In the second part of this study, we determined the differential expression (between tumor/non-tumor groups) of microRNA in cervical cancer FFPE tissue samples. We determined the comprehensive miRNA expression profile using small-RNA sequencing technology and verified the results by real-time PCR. We determined the relative expression of selected miRNAs using the 2-ΔΔCt method.

Results

We detected statistically significant upregulation of miR-320a-3p, miR-7704, and downregulation of miR-26a-5p in the tumor group compared to the control group. The combination of these miRNAs may have the potential to be utilized as a diagnostic panel for cervical cancer. Using ROC curve analysis, the proposed panel showed 93.33% specificity and 96.97% sensitivity with AUC = 0.985.

Conclusions

We proposed a combination of miR-181a-5p and miR-423-3p as optimal endogenous control and detected potentially significant miRNAs (miR-320a-3p, miR-7704, miR-26a-5p). After further validation of our results, these miRNAs could be used in a diagnostic panel for cervical cancer.
Colorectal surveillance outcomes from an institutional longitudinal cohort of lynch syndrome carriers
Authors: del Carmen Gabriel , Reyes-Uribe Laura , Goyco Daniel , Evans Kyera , Bowen Charles M. , Kinnison Jennifer L. , Sepeda Valerie O. , Weber Diane M. , Moskowitz Julie , Mork Maureen E. , Thirumurthi Selvi , Lynch Patrick M. , Rodriguez-Bigas Miguel A. , Taggart Melissa W. , You Y. Nancy , Vilar Eduardo
Published: April 2023

Objective

Lynch Syndrome (LS) carriers have a significantly increased risk of developing colorectal cancer (CRC) during their lifetimes. Further stratification of this patient population may help in identifying additional risk factors that predispose to colorectal carcinogenesis. In most LS patients CRC may arise from adenomas, although an alternative non-polypoid carcinogenesis pathway has been proposed for PMS2 carriers. Using data from our institutional LS cohort, our aim was to describe our current colorectal screening outcomes with a focus on the incidence of adenomas in the context of different MMR genotypes and patient demographics such as gender, race, and ethnicity.

Design

We collected demographics, genetic, colonoscopy, and pathology results from a total of 163 LS carriers who obtained regular screening care at MD Anderson Cancer Center. Data were extracted from the electronic health records into a REDCap database for analysis. Logistic regressions were performed to measure the association between MMR variants and the likelihood of adenomas, advanced adenomas, and CRC. Then, we analyzed the cumulative incidences of these outcomes for the first 36 months following enrollment using Kaplan-Meier incidence curves, and Cox proportional hazard regressions.

Results

On multivariate analysis, age (≥45 years old) was associated with an increased risk of developing adenomas (P=0.034). Patients with a prior or active cancer status were less likely to develop adenomas (P=0.015), despite of the lack of association between surgical history with this outcome (P=0.868). We found no statistically significant difference in likelihood of adenoma development between MLH1 and MSH2/EPCAM, MSH6, and PMS2 carriers. Moreover, we observed no statistically significant difference in the likelihood of advanced adenomas or CRC for any measured covariates. On Cox proportional hazard, compared to MLH1 carriers, the incidence of adenomas was highest among MSH2/EPCAM carriers during for the first 36-months of follow-up (P<0.001). We observed a non-statistically significant trend for Hispanics having a higher and earlier cumulative incidence of adenomas compared to non-Hispanics (P=0.073). No MMR carrier was more likely to develop advanced adenomas. No difference in the incidence of CRC by MMR gene (P=0.198).

Conclusion

Screening recommendations for CRC in LS patients should be based on specific MMR variants and should also be tailored to consider patient demographics.
Molecular detection and quantification of Plasmodium vivax DNA in blood pellet and plasma samples from patients in Senegal
Authors: Sambe Babacar Souleymane , Diagne Aissatou , Diatta Hélène Ataume Mawounge , Gaba Folly Mawulolo , Sarr Ibrahima , Diatta Arona Sabène , Diaw Serigne Ousmane Mbacké , Sané Rokhaya , Diouf Babacar , Vigan-Womas Inès , Mbengue Babacar , Niang Makhtar
Published: April 2023

Background

The first discovery of Plasmodium vivax infections in Senegal used archived patients’ sera in place of blood pellet, the preferred specimen for the molecular diagnosis of Plasmodium species. The present study assessed the reliability of detecting P. vivax DNA in plasma in comparison to blood pellet from the same patient’s samples.

Methods

A total of 616 blood samples obtained from febrile patients living in Kolda (2015 and 2020), Tambacounda (2017 and 2020), and Kedougou (2020) regions in Senegal, were first screened for Plasmodium species composition by 18S ssrRNA-based nested PCR. Paired blood pellets and plasma samples were selected from a subset of 50 P. vivax-positive patients matched by age and sex with 50 P. vivax-negative patients, and subjected to a cytochrome b-based qPCR to compare the detection and quantification of P. vivax genomic DNA between the two specimen types.

Results and discussion

The study reports 1.8% and 14.77% of single and mixed P. vivax infections in the study population, and a high concordance (84%) between the qPCR detection of P. vivax genomic DNA from paired blood pellets and plasma samples. Importantly, all P. vivax negative samples from the blood pellets were also confirmed plasma-negative, and parasitaemia in blood pellets was higher compared to plasma samples. The results support investigations of P. vivax infections in archived sera or plasma collections with a high degree of confidence to generate additional data on the neglected P. vivax malaria, and ultimately guide strategies to control the disease.
Subtyping intractable functional constipation in children using clinical and laboratory data in a classification model
Authors: Huang Yi-Hsuan , Xie Chenjia , Chou Chih-Yi , Jin Yu , Li Wei , Wang Meng , Lu Yan , Liu Zhifeng
Published: April 2023

Background

Children with intractable functional constipation (IFC) who are refractory to traditional pharmacological intervention develop severe symptoms that can persist even in adulthood, resulting in a substantial deterioration in their quality of life. In order to better manage IFC patients, efficient subtyping of IFC into its three subtypes, normal transit constipation (NTC), outlet obstruction constipation (OOC), and slow transit constipation (STC), at early stages is crucial. With advancements in technology, machine learning can classify IFC early through the use of validated questionnaires and the different serum concentrations of gastrointestinal motility-related hormones.

Method

A hundred and one children with IFC and 50 controls were enrolled in this study. Three supervised machine-learning methods, support vector machine, random forest, and light gradient boosting machine (LGBM), were used to classify children with IFC into the three subtypes based on their symptom severity, self-efficacy, and quality of life which were quantified using certified questionnaires and their serum concentrations of the gastrointestinal hormones evaluated with enzyme-linked immunosorbent assay. The accuracy of machine learning subtyping was evaluated with respect to radiopaque markers.

Results

Of 101 IFC patients, 37 had NTC, 49 had OOC, and 15 had STC. The variables significant for IFC subtype classification, according to SelectKBest, were stool frequency, the satisfaction domain of the Patient Assessment of Constipation Quality of Life questionnaire (PAC-QOL), the emotional self-efficacy for Functional Constipation questionnaire (SEFCQ), motilin serum concentration, and vasoactive intestinal peptide serum concentration. Among the three models, the LGBM model demonstrated an accuracy of 83.8%, a precision of 84.5%, a recall of 83.6%, a f1-score of 83.4%, and an area under the receiver operating characteristic curve (AUROC) of 0.89 in discriminating IFC subtypes.

Conclusion

Using clinical characteristics measured by certified questionnaires and serum concentrations of the gastrointestinal hormones, machine learning can efficiently classify pediatric IFC into its three subtypes. Of the three models tested, the LGBM model is the most accurate model for the classification of IFC, with an accuracy of 83.8%, demonstrating that machine learning is an efficient tool for the management of IFC in children.
Global publication trends and research trends of necroptosis application in tumor: A bibliometric analysis
Authors: Wu Yun-Yun , Li Chang-chun , Lin Xiao , Xu Feng , Shan Su-Kang , Guo Bei , Li Fu-Xing-Zi , Zheng Ming-Hui , Xu Qiu-Shuang , Lei Li-Min , Duan Jia-Yue , Tang Ke-Xin , Cao Ye-Chi , Yuan Ling-Qing
Published: April 2023

Introduction: Necroptosis is an alternative, caspase-independent programmed cell death that appears when apoptosis is inhibited. A gowing number of studies have reflected the link between necroptosis and tumors. However, only some systematical bibliometric analyses were focused on this field. In this study, we aimed to identify and visualize the cooperation between countries, institutions, authors, and journals through a bibliometric analysis to help understand the hotspot trends and emerging topics regarding necroptosis and cancer research.

Methods: The articles and reviews on necroptosis and cancer were obtained from the Web of Science Core Collection on 16 September 2022. Countries, institutions, authors, references, and keywords in this field were visually analyzed by CtieSpace 5.8.R3, VOSviewer 1.6.18, and R package “bibliometrix.”

Results: From 2006 to 2022, 2,216 qualified original articles and reviews on necroptosis in tumors were published in 685 academic journals by 13,009 authors in 789 institutions from 75 countries/regions. Publications focusing on necroptosis and cancer have increased violently in the past 16 years, while the citation number peaked around 2008–2011. Most publications were from China, while the United States maintained the dominant position as a “knowledge bridge” in necroptosis and cancer research; meanwhile, Ghent University and the Chinese Academy of Sciences were the most productive institutions. Moreover, only a tiny portion of the articles were multiple-country publications. Peter Vandenabeele had the most significant publications, while Alexei Degterev was most often co-cited. Peter Vandenabeele also gets the highest h-index and g-index in this research field. Cell Death and Disease was the journal with the most publications on necroptosis and cancer, which was confirmed to be the top core source by Bradford’s Law. At the same time, Cell was the leading co-cited journal, and the focus area of these papers was molecular, biology, and immunology. High-frequency keywords mainly contained those that are molecularly related (MLKL, NF-kB, TNF, RIPK3, RIPK1), pathological process related (necroptosis, apoptosis, cell-death, necrosis, autophagy), and mechanism related (activation, expression, mechanisms, and inhibition).

Conclusion: This study comprehensively overviews necroptosis and cancer research using bibliometric and visual methods. Research related to necroptosis and cancer is flourishing. Cooperation and communication between countries and institutions must be further strengthened. The information in our paper would provide valuable references for scholars focusing on necroptosis and cancer.
Reactivation of mutant p53 in esophageal squamous cell carcinoma by isothiocyanate inhibits tumor growth
Authors: Guan Lulu , Yang Yalan , Lu Yao , Chen Yu , Luo Xi , Xin Dao , Meng Xiangrui , Shan Zhengzheng , Jiang Guozhong , Wang Feng
Published: April 2023

p53 mutations are prevalent in human cancers; approximately half of patients with esophageal cancer present these mutations. Mutant p53 (mutp53) exerts oncogenic functions that promote malignant tumor progression, invasion, metastasis, and drug resistance, resulting in poor prognosis. Some small molecules have been shown to mitigate the oncogenic function of mutp53 by restoring its wild-type activity. Although these molecules have been evaluated in clinical trials, none have been successfully used in the clinic. Here, we investigated the antitumor effects of phenethyl isothiocyanate (PEITC) in p53-mutant esophageal squamous cell carcinoma (ESCC) and elucidated its mechanism to identify new therapeutic strategies. We observed that p53R248Q is a DNA contact mutation and a structural mutation and that PEITC can restore the activity of p53R248Qin vitro and in vivo, further clarifying the antitumor activity of PEITC in cancers with different types of p53 mutations. PEITC can inhibit ESCC growth, induce apoptosis, and arrest cell cycle progression and has a preferential selectivity for ESCC with p53 mutations. Mechanistic studies showed that PEITC induced apoptosis and arrested cells at G2/M transition in cells expressing the p53R248Q mutant by restoring the wild-type conformation and transactivation function of p53; these effects were concentration dependent. Furthermore, PEITC inhibited the growth of subcutaneous xenografts in vivo and restored p53 mutant activity in xenografts. According to these findings, PEITC has antitumor effects, with its ability to restore p53R248Q activity being a key molecular event responsible for these effects.
Stimulatory effects of Lycium shawii on human melanocyte proliferation, migration, and melanogenesis: In vitro and in silico studies
Authors: Alghamdi Khalid , Alehaideb Zeyad , Kumar Ashok , Al-Eidi Hamad , Alghamdi Sahar S. , Suliman Rasha , Ali Rizwan , Almourfi Feras , Alghamdi Saleh M. , Boudjelal Mohamed , Matou-Nasri Sabine
Published: April 2023

There is no first-line treatment for vitiligo, a skin disease characterized by a lack of melanin produced by the melanocytes, resulting in an urgent demand for new therapeutic drugs capable of stimulating melanocyte functions, including melanogenesis. In this study, traditional medicinal plant extracts were tested for cultured human melanocyte proliferation, migration, and melanogenesis using MTT, scratch wound-healing assays, transmission electron microscopy, immunofluorescence staining, and Western blot technology. Of the methanolic extracts, Lycium shawii L. (L. shawii) extract increased melanocyte proliferation at low concentrations and modulated melanocyte migration. At the lowest tested concentration (i.e., 7.8 μg/mL), the L. shawii methanolic extract promoted melanosome formation, maturation, and enhanced melanin production, which was associated with the upregulation of microphthalmia-associated transcription factor (MITF), tyrosinase, tyrosinase-related protein (TRP)-1 and TRP-2 melanogenesis-related proteins, and melanogenesis-related proteins. After the chemical analysis and L. shawii extract-derived metabolite identification, the in silico studies revealed the molecular interactions between Metabolite 5, identified as apigenin (4,5,6-trihydroxyflavone), and the copper active site of tyrosinase, predicting enhanced tyrosinase activity and subsequent melanin formation. In conclusion, L. shawii methanolic extract stimulates melanocyte functions, including melanin production, and its derivative Metabolite 5 enhances tyrosinase activity, suggesting further investigation of the L. shawii extract-derived Metabolite 5 as a potential natural drug for vitiligo treatment.
New measurements of 92Mo(γ, n) and (γ, 3n) reactions using laser-driven bremsstrahlung γ-ray
Authors: Wu D. , Lan H. Y. , Zhang J. Y. , Liu J. X. , Lu H. G. , Lv J. F. , Wu X. Z. , Zhang H. , Cai J. , Xu X. L. , Geng Y. X. , Ma W. J. , Lin C. , Zhao Y. Y. , Wang H. R. , Liu F. L. , He C. Y. , Yu J. Q. , Guo B. , Wang N. Y. , Yan X. Q.
Published: April 2023

The flux-weighted average cross sections and isomeric ratios of 92Mo(γ, n)91m,gMo and 92Mo(γ, 3n)89Mo reactions were measured through activation methods. Laser-driven bremsstrahlung γ-ray were generated by the laser wakefield accelerated quasi-monoenergetic electrons using the 200 TW laser in the Compact Laser Plasma Accelerator laboratory, Peking University. The results showed good agreements with previous works using traditional γ-ray sources, and were compared with TALYS 1.9 calculations. We extended the experimental results of 92Mo photonuclear reactions to higher energies, the experimental discrepancies of 92Mo(γ, n)91m,gMo isomeric ratios at high energy region were clarified, and the cross sections of 92Mo(γ, 3n)89Mo reaction were first obtained.
Myography of isolated blood vessels: Considerations for experimental design and combination with supplementary techniques
Authors: Schubert Rudolf , Gaynullina Dina , Shvetsova Anastasia , Tarasova Olga S.
Published: April 2023

The study of the mechanisms of regulation of vascular tone is an urgent task of modern science, since diseases of the cardiovascular system remain the main cause of reduction in the quality of life and mortality of the population. Myography (isometric and isobaric) of isolated blood vessels is one of the most physiologically relevant approaches to study the function of cells in the vessel wall. On the one hand, cell-cell interactions as well as mechanical stretch of the vessel wall remain preserved in myography studies, in contrast to studies on isolated cells, e.g., cell culture. On the other hand, in vitro studies in isolated vessels allow control of numerous parameters that are difficult to control in vivo. The aim of this review was to 1) discuss the specifics of experimental design and interpretation of data obtained by myography and 2) highlight the importance of the combined use of myography with various complementary techniques necessary for a deep understanding of vascular physiology.
Effects of experimentally induced self-affirmation on the openness to meat reduction and alternative protein sources
Authors: Branković Marija , Budžak Anastasija , Tulić Nađa , Janković Jovana
Published: April 2023

Introduction

Consumption of animals entails disregarding the pain of sentient beings, and acknowledging this can threaten an individual’s image of oneself as a moral person. Also, abstaining from meat in a meat-eating culture can threaten an individual’s valued group identity. Previous research on inter-group relations suggests that self-affirmation, affirmation of personally or collectively important values, can help individuals alleviate self-threats since it enhances one’s global self-image and decreases threat perceptions.

Methods

We tested for potential effects of self-affirmation on openness toward reducing meat consumption in an experimental study. Participants (N= 277) were randomized into an individual affirmation, group affirmation, or a control condition. Individual affirmation participants ranked a list of values and then wrote a short paragraph about their first-ranked value. Group affirmation participants did a similar task, focusing on the values of their ethnic group, while participants in the control condition had an unrelated task of ranking their color preferences. Participants then read a persuasive message presenting health risks related to meat consumption and the health benefits of reducing meat. Finally, they indicated their openness toward reducing meat consumption and acceptability of plant-based alternatives and lab-grown meat.

Results and Discussion

Results show that affirmed participants expressed more readiness to reconsider their meat consumption habits, reduced perceptions of vegetarianism as a threat to the local culture, and more positive perceptions of the idea of lab-grown meat. However, self-esteem and frequency of meat consumption pose important limitations to the experimental effects. We discuss the findings from the perspective of self-and collective identity threats and the potential of self-affirmations to create a more open debate about animal product consumption.
Mediation effects of positive and negative affect on the relationship between emotional intelligence and life satisfaction in rural school teachers
Authors: Deng Xiaoxiang , Chen Jiasheng , Zhao Yuyang
Published: April 2023

Few studies have investigated the ways in which the specific facets of trait emotional intelligence (EI), positive affect (PA), and negative affect (NA) influence individuals’ general life satisfaction, especially in teachers. This study explored the effects of three facets of trait EI [appraisal and expression of emotions (AEE), utilization of emotion (UE), and regulation of emotions (RE)] and two typical affects (PA and NA) on teachers’ general life satisfaction. The participants were 577 Chinese rural school teachers (ages 18–49 years) who completed three questionnaires—the Schutte Self-Report Emotional Intelligence Test, Positive and Negative Affective scale, and Satisfaction with Life Scale. After validating the scales, a structural equation modeling analysis showed that trait EI, PA, and NA had a significant and positive effect on teachers’ general life satisfaction. PA played a partial mediating role between trait EI and life satisfaction. Furthermore, this study found that PA significantly and positively mediated the relationship between AEE, UE, RE, and life satisfaction. These results suggest that teachers with higher EI are more likely to have positive emotions, thereby enhancing their general life satisfaction, and that understanding the role of one’s own and others’ emotions and increasing positive emotions may be the key to improving teachers’ general life satisfaction. Future implications and the study limitations are discussed.
Social representations of mask wearing in the general population during the COVID-19 pandemic
Authors: Bornand Elvire , Letourneux Frédérique , Deschanvres Colin , Boutoille David , Lucet Jean-Christophe , Lepelletier Didier , Leclere Brice , Mayol Séverine , Peiffer-Smadja Nathan , Birgand Gabriel
Published: April 2023

Introduction

Although one of the most prominent interventions against COVID-19, face masks seem poorly adopted by the general population. A growing body of literature has found that using face masks has social meaning. This qualitative study assessed the perceptions, representations and practices of mask wearing in the general population.

Methods

A qualitative survey by short semi-structured walking interviews was carried out from April to December 2021 in 11 cities in France's Pays de la Loire region. Study locations were selected for their varied geographical, social, and economic characteristics, with urbanized and rural areas. Four domains linked to perceptions of masks and wearing them were explored: (i) evolution in mask wearing, (ii) decision-making methods for wearing and not wearing; (iii) incorporating the mask into way of life; (iv) projecting into the future.

Results

A total of 116 people were interviewed. Masks marked a shift from the ordinary world to the pandemic. Overall, interviewees considered masks an obstacle to breathing, communication, and social interactions, leading to establishing strategies circumventing the mask mandate. Poor attention was paid to their medical usefulness as an obligatory clothing accessory. Mask-wearing decisions were driven by social relations, common sense, and vulnerability. The greater the feeling of security (i.e., being with close relatives), the less it was worn or worn properly, with decreased attention to others and their health. Most participants did not remember learning to wear a mask. Some were convinced that mask-wearing could not be learned (experiential knowledge). Institutions (school and work) played a central role by facilitating incorporation of masks into daily life.

Conclusions

This study emphasizes the need to reinforce the individual medical values of face masks to prevent COVID-19. Ambitious education and training programmes should be planned to learn how and when to wear masks. Institutions (work and school) may be critical for this purpose.
No silver bullet: interpretable ML models must be explained
Authors: Marques-Silva Joao , Ignatiev Alexey
Published: April 2023

Recent years witnessed a number of proposals for the use of the so-called interpretable models in specific application domains. These include high-risk, but also safety-critical domains. In contrast, other works reported some pitfalls of machine learning model interpretability, in part justified by the lack of a rigorous definition of what an interpretable model should represent. This study proposes to relate interpretability with the ability of a model to offer explanations of why a prediction is made given some point in feature space. Under this general goal of offering explanations to predictions, this study reveals additional limitations of interpretable models. Concretely, this study considers application domains where the purpose is to help human decision makers to understand why some prediction was made or why was not some other prediction made, and where irreducible (and so minimal) information is sought. In such domains, this study argues that answers to such why (or why not) questions can exhibit arbitrary redundancy, i.e., the answers can be simplified, as long as these answers are obtained by human inspection of the interpretable ML model representation.
The extent to which circular economy principles have been applied in the design of medical devices for low-resource settings in Sub-Saharan Africa. A systematic review
Authors: Samenjo Karlheinz Tondo , Oosting Roos Marieke , Bakker Conny , Diehl Jan Carel
Published: April 2023

Healthcare facilities in low-resource settings in Sub-Saharan Africa are plagued with issues of non-functional and obsolete medical devices, which ultimately end up prematurely disposed of as waste. With increasing healthcare demands, stopping medical device disposal is imperative. One way to achieve this is to leverage circular economy principles in designing medical devices. Circular economy principles aim to retain products and their constituent materials to be reused over time in the economic system. However, to what extent this has been applied in designing medical devices specifically for low-resource settings in Sub-Saharan Africa is missing in literature. Based on a systematic review of 29 out of 1,799 screened scientific papers, we identified the use of circular economy principles of durability, maintenance, repair, and upgrade in designing medical devices for this setting. Whether these principles were intentionally applied from a circular economy approach could not be inferred in this study. The motivational basis for using these principles was to ensure medical device longevity to providing healthcare. No attention was given to the circular economy principles of refurbishment, remanufacturing, and recycling, ensuring that device components and constituent materials are recovered. These study findings serve as a launchpad for exploring how circular principles can be used to support the design of medical devices for low-resource settings in Sub-Saharan Africa. Academicians and designers of medical devices can leverage this research to contribute towards developing medical devices that support access to healthcare for people in low-resource settings and preserve earth's finite resources.
Critical gaps in nanoplastics research and their connection to risk assessment
Authors: Cunningham Brittany E. , Sharpe Emma E. , Brander Susanne M. , Landis Wayne G. , Harper Stacey L.
Published: April 2023

Reports of plastics, at higher levels than previously thought, in the water that we drink and the air that we breathe, are generating considerable interest and concern. Plastics have been recorded in almost every environment in the world with estimates on the order of trillions of microplastic pieces. Yet, this may very well be an underestimate of plastic pollution as a whole. Once microplastics (<5 mm) break down in the environment, they nominally enter the nanoscale (<1,000 nm), where they cannot be seen by the naked eye or even with the use of a typical laboratory microscope. Thus far, research has focused on plastics in the macro- (>25 mm) and micro-size ranges, which are easier to detect and identify, leaving large knowledge gaps in our understanding of nanoplastic debris. Our ability to ask and answer questions relating to the transport, fate, and potential toxicity of these particles is disadvantaged by the detection and identification limits of current technology. Furthermore, laboratory exposures have been substantially constrained to the study of commercially available nanoplastics; i.e., polystyrene spheres, which do not adequately reflect the composition of environmental plastic debris. While a great deal of plastic-focused research has been published in recent years, the pattern of the work does not answer a number of key factors vital to calculating risk that takes into account the smallest plastic particles; namely, sources, fate and transport, exposure measures, toxicity and effects. These data are critical to inform regulatory decision making and to implement adaptive management strategies that mitigate risk to human health and the environment. This paper reviews the current state-of-the-science on nanoplastic research, highlighting areas where data are needed to establish robust risk assessments that take into account plastics pollution. Where nanoplastic-specific data are not available, suggested substitutions are indicated.
Solving an Industrial-Scale Warehouse Delivery Problem with Answer Set Programming Modulo Difference Constraints
Authors: Rajaratnam David , Schaub Torsten , Wanko Philipp , Chen Kai , Liu Sirui , Son Tran Cao
Published: April 2023

A warehouse delivery problem consists of a set of robots that undertake delivery jobs within a warehouse. Items are moved around the warehouse in response to events. A solution to a warehouse delivery problem is a collision-free schedule of robot movements and actions that ensures that all delivery jobs are completed and each robot is returned to its docking station. While the warehouse delivery problem is related to existing research, such as the study of multi-agent path finding (MAPF), the specific industrial requirements necessitated a novel approach that diverges from these other approaches. For example, our problem description was more suited to formalizing the warehouse in terms of a weighted directed graph rather than the more common grid-based formalization. We formalize and encode the warehouse delivery problem in Answer Set Programming (ASP) extended with difference constraints. We systematically develop and study different encoding variants, with a view to computing good quality solutions in near real-time. In particular, application specific criteria are contrasted against the traditional notion of makespan minimization as a measure of solution quality. The encoding is tested against both crafted and industry data and experiments run using the Hybrid ASP solver clingo[dl].
Enhancing the Distributed Acoustic Sensors’ (DAS) Performance by the Simple Noise Reduction Algorithms Sequential Application
Authors: Turov Artem T. , Konstantinov Yuri A. , Barkov Fedor L. , Korobko Dmitry A. , Zolotovskii Igor O. , Lopez-Mercado Cesar A. , Fotiadi Andrei A.
Published: April 2023

Moving differential and dynamic window moving averaging are simple and well-known signal processing algorithms. However, the most common methods of obtaining sufficient signal-to-noise ratios in distributed acoustic sensing use expensive and precise equipment such as laser sources, photoreceivers, etc., and neural network postprocessing, which results in an unacceptable price of an acoustic monitoring system for potential customers. This paper presents the distributed fiber-optic acoustic sensors data processing and noise suppression techniques applied both to raw data (spatial and temporal amplitude distributions) and to spectra obtained after the Fourier transform. The performance of algorithms’ individual parts in processing distributed acoustic sensor’s data obtained in laboratory conditions for an optical fiber subjected to various dynamic impact events is studied. A comparative analysis of these parts’ efficiency was carried out, and for each type of impact event, the most beneficial combinations were identified. The feasibility of existing noise reduction techniques performance improvement is proposed and tested. Presented algorithms are undemanding for computation resources and provide the signal-to-noise ratio enhancement of up to 13.1 dB. Thus, they can be useful in areas requiring the distributed acoustic monitoring systems’ cost reduction as maintaining acceptable performance while allowing the use of cheaper hardware.
Conceptual Design and Optimization of Distributed Electric Propulsion General Aviation Aircraft
Authors: Wu Jiang , Gao Feng , Li Shengwen , Yang Fengtian
Published: April 2023

The interaction between the slipstream of the propellers and the wing of an aircraft with distributed electric propulsion (DEP) could benefit aerodynamics. A conceptual design and optimization are carried out in order to increase the range of an electric general aviation aircraft without affecting its takeoff and landing velocity in the same fuselage condition. Propellers are modelled using the actuator disk (AD) theory, and the aircraft is modelled using the vortex lattice method (VLM) to obtain DEP aircraft’s aerodynamics in conceptual design. The DIRECT method is used for global optimization. To concentrate on the layout of the propellers and wing, a propeller with the same chord distribution, twist distribution, and number of blades is selected. The design and optimization of DEP aircraft’s range is carried out with the objective of achieving the maximum product of the lift–drag ratio with propeller efficiency under force balance constrains. Additionally, to decrease the takeoff and landing distance, the DEP aircraft’s takeoff and landing performance are optimized with the objective of the smallest velocity at an angle near the tail down angle under the constrains of acceleration bigger than 0 and a Mach number at the tip of blades smaller than 0.7. The CFD simulation was used to confirm the DEP aircraft’s pretty accurate aerodynamics. Compared to the reference aircraft, the improved DEP aircraft with 10 high-lift propellers on the leading edge of the wing and 2 wing-tip propellers may boost cruise performance by 6% while maintaining takeoff and landing velocity. Furthermore, it has been shown that the stall speed of DEP aircraft with smaller wings would rise proportionally when compared to conventional design aircraft, and the power need of DEP aircraft will be increased as a result of the operation of high-lift propellers. The conceptual design and optimal approach suggested in this work has some reference value for the design and research of the fixed-wing DEP general aviation aircraft.
The Exact Solution of the Bending Moment in the Folding Process of Negative Poisson’s Ratio Honeycomb Tape Spring and Multi-Objective Optimization Design
Authors: Yang Yang , Wang Fan , Liu Jieshan
Published: April 2023

The tape spring is a crucial component used in the deployment mechanism of spacecraft, and the lightweight design of the deployment mechanism is currently one of the critical issues that need to be addressed. This paper explores the substitution effect of two different negative Poisson’s ratio honeycomb-corrugated spring structures for use in space-deployable structures. Theoretical and finite element methods demonstrated that the negative Poisson’s ratio honeycomb structure could be equivalent to an orthotropic structure. The cylindrical shell bending theory was adopted, taking into account the nonlinearity of the geometric equation, the influence of cross-sectional deformation and cross-sectional position on the internal force expression, and the influence of the geometric equation to derive expressions for the bending moment and curvature radius during the folding and bending process. Numerical methods were used for comparative analysis. The NSGA-II algorithm optimized the geometric parameters of the negative Poisson’s ratio honeycomb, resulting in the optimal solution under given constraints. The results showed that the Auxetic re-entrant honeycomb structure performed better in bending moment capacity than the Star-shaped honeycomb, and the bending moment capacity of the Auxetic re-entrant honeycomb structure per unit mass was superior to that of the traditional tape spring.
Development of a High-Performance Low-Weight Hydraulic Damper for Active Vibration Control of the Main Rotor on Helicopters—Part 1: Design and Mathematical Model
Authors: Bertolino Antonio Carlo , Gaidano Matteo , Smorto Stefano , Porro Paolo Giovanni , Sorli Massimo
Published: April 2023

The helicopter vibrations generated by the main rotor/gearbox assembly are the principal cause of damage to cockpit instruments and discomfort of the crew in terms of cabin noise. The principal path of vibration transmission to the fuselage is through the gearbox rigid support struts. With the aim of reducing these vibrations, this paper presents the design of a low-weight high-performance active damper for vibration control developed by Elettronica Aster S.p.A. The system is intended to replace the conventional struts and is composed of an electro-hydraulic actuator hosted within a compliant structure. This parallel nested structure allows the system to reach a high-power density. A physics-based mathematical model was used as a design digital twin to optimize the performance to meet the strict requirements. The active damper was designed for a reference application of a 15-seat medium-sized twin-engine helicopter. The model was used to perform the tests specified in the acceptance and testing procedure document, showing the compliance with the requirements of the current design. The damper physical realization, test bench design, experimental campaign, and model validation will be presented in Part 2.
Carbon Emissions from Agricultural Inputs in China over the Past Three Decades
Authors: Song Shixiong , Zhao Siyuan , Zhang Ye , Ma Yongxi
Published: April 2023

Global warming has become one of the major threats to the security of human survival, security, and sustainable development. Agricultural production has been widely suspected as one of the main sources of anthropogenic carbon emissions. Analyzing the changing characteristics and influencing factors of agricultural carbon emissions is of great significance for the mitigation of global climate change and the sustainable development in agriculture. Taking China, a large agricultural country, as an example, this study used the empirical model to quantify carbon emissions from agricultural inputs from 1991 to 2019, and analyzed the driving factors using ridge regression. We found that agricultural carbon emissions in China have been on the rise in the past 30 years, but at a markedly slower pace. From 2008 to 2019, the average annual growth rate of agricultural carbon emissions was 1.47%, down significantly from 2.92% between 1991 and 2007. The carbon emissions per unit of planting area showed an overall increasing trend, which grew from 179.35 t ce/km2 to 246.26 t ce/km2, with an average annual growth rate of 1.13%. The carbon emissions per unit of agricultural output mainly showed a decreasing trend, which decreased from 0.52 kg ce/CNY to 0.06 kg ce/CNY, with an average annual rate of change of −7.42%. China’s agricultural carbon emissions were closely related to macro-policies. Fertilizer inputs, agricultural industry structure, and energy use intensity were significantly positively correlated with carbon emission intensity. The degree of urban feedback to rural areas, public investment in agriculture, and large-scale planting were significantly negatively correlated with carbon emission intensity, but the impacts of these factors had a “lag effect”. In order to reduce carbon emissions from agriculture and promote development in green agriculture, we suggest that the government should further increase the degree of urban feedback to rural and public investment in the agricultural sector. In addition, large-scale agricultural production should be encouraged to increase resource efficiency and reduce carbon emissions.