bluuebunny/crossref_metadata_2025 huggingface dataset:
Operational Disruptions, Firm Risk, and Control Systems
Authors: Schmidt William , Raman Ananth
Published: March 2021

Problem definition: Operational disruptions can impact a firm’s risk, which manifests in a host of operational issues, including a higher holding cost for inventory, a higher financing cost for capacity expansion, and a higher perception of the firm’s risk among its supply chain partners. Academic/practical relevance: Although disruptions have been studied extensively in the operations management literature, the emphasis has been on mitigating the deleterious impact on the firm’s production potential rather than its risk. We examine whether implementing and credibly attesting to having effective internal control systems will meaningfully influence the impact of operational disruptions on the firm’s risk and market valuation. Methodology: We exploit a 2004 regulatory change that required certain firms to attest to having control systems in place. Our triple-difference regression specification takes advantage of a regulatory anomaly that excluded a well-defined set of firms from complying with the control system requirement. Results: We find that firms that were obligated to comply with this regulatory requirement experienced a materially smaller increase in their risk and a smaller decrease in their market value in the aftermath of an operational disruption. Firms that were not obligated to comply with this requirement did not experience such benefits in the aftermath of a disruption and instead, experienced a larger increase in their risk. Managerial implications: Fostering a better understanding of whether credible control systems can reduce the impact of disruptions on the firm’s risk and value is important as it identifies a broader set of mitigation strategies available to operations managers. This can help managers achieve a better fit between their risk mitigation initiatives and their objectives and budget constraints.
Intraday Scheduling with Patient Re-entries and Variability in Behaviours
Authors: Zhou Minglong , Loke Gar Goei , Bandi Chaithanya , Liau Zi Qiang Glen , Wang Wilson
Published: March 2021

Problem definition: We consider the intraday scheduling problem in a group of orthopaedic clinics where the planner schedules appointment times, given a sequence of appointments. We consider patient re-entry—where patients may be required to go for an x-ray examination, returning to the same doctor they have seen—and variability in patient behaviours such as walk-ins, earliness, and no-shows, which leads to inefficiency such as long patient waiting time and physician overtime. Academic/practical relevance: In our data set, 25% of the patients are required to go for x-ray examination. We also found significant variability in patient behaviours. Hence, patient re-entry and variability in behaviours are common, but we found little in the literature that could handle them. Methodology: We formulate the problem as a two-stage optimization problem, where scheduling decisions are made in the first stage. Queue dynamics in the second stage are modeled under a P-Queue paradigm, which minimizes a risk index representing the chance of violating performance targets, such as patient waiting times. The model reduces to a sequence of mixed-integer linear-optimization problems. Results: Our model achieves significant reductions, in comparative studies against a sample average approximation (SAA) model, on patient waiting times, while keeping server overtime constant. Our simulations further characterize the types of uncertainties under which SAA performs poorly. Managerial insights: We present an optimization model that is easy to implement in practice and tractable to compute. Our simulations indicate that not accounting for patient re-entry or variability in patient behaviours will lead to suboptimal policies, especially when they have specific structure that should be considered.
Architectural Search and Innovation
Authors: Albert Daniel , Siggelkow Nicolaj
Published: March 2021

Product innovation can result from the novel design and combination of product components as well as from changing the underlying architecture: that is, the way components interact with each other. Even though previous studies have shown that architectural change can constitute a powerful source of innovation, little insight exists on how organizations should engage in architectural search itself. In this paper, using computer simulation, we explore underlying mechanisms of architectural search. We find that contrary to search for component combinations, architectural search provides greater performance improvements the narrower the search scope, regardless of product complexity. Moreover, our theory and findings suggest a more differentiated typology of architectural innovation. Although narrow architectural search often leads to pure architectural innovations that do not require substantial component changes, broader architectural search often leads to composite architectural innovation (i.e., architectural innovations that typically render existing component designs suboptimal but allow for new high-performing component combinations to arise). Lastly, although narrow architectural search outperforms broad architectural search in the long run, in the short run broad architectural search can have performance advantages.
Impact of technology on community nursing during the pandemic
Authors: Grindle Kathryn Rose
Published: March 2021

The purpose of this article is critical analysis, reflection and discussion in regards to the uses and impacts technology has had in community settings, specifically care homes during the COVID-19 pandemic. This will be investigated and supported with special emphasis on virtual assessment platforms and their use within the care homes settings, furthermore reviewing specific data collected in relation to the usage within community care homes. The article will outline the positive attributes and critically reflect upon the benefits of using audio and video conferencing when assessing patients and the beneficial impacts this has had on patients and the wider health community. While conversely addressing the obstacles and threats faced by clinicians in the use of assessment software.
Perceptions, practices and educational needs of community nurses to manage frailty
Authors: Papadopoulou Constantina , Barrie Janette , Andrew Mandy , Martin Janetta , Birt Audrey , Raymond Duffy FJ , Hendry Anne
Published: March 2021

Early intervention on frailty can help prevent or delay functional decline and onset of dependency. Community nurses encounter patients with frailty routinely and have opportunities to influence frailty trajectories for individuals and their carers. This study aimed to understand nurses' perceptions of frailty in a community setting and their needs for education on its assessment and management. Using an exploratory qualitative design we conducted focus groups in one Health Board in Scotland. Thematic content analysis of data was facilitated by NVivo© software. A total of 18 nurses described the meaning of frailty as vulnerability, loss and complex comorbidity and identified processes of caring for people with frailty. They identified existing educational needs necessary to support their current efforts to build capability through existing adversities. Our study indicates that current practice is largely reactive, influenced by professional judgement and intuition, with little systematic frailty-specific screening and assessment.
Role of the podiatrist and common foot problems
Authors: Farndon Lisa
Published: March 2021

In this article, the author discusses the role of the podiatrist in sustaining and maintaining foot health. A number of core podiatry problems that are most commonly seen in the population are described, along with possible treatment options and when to refer to a podiatrist. The author also explains what is required to carry out a diabetic foot assessment, providing helpful links to resources and literature to aid practitioners' understanding of the processes involved, as well as providing a list of foot care tips to aid self-care.
Transition to practice: from student to NQP
Authors: Costello Barry
Published: March 2021

In his first column as an NQP, Barry Costello reflects on his transition and ‘student brain’
Diversity of fungi associated with rhizosphere of healthy and diseased garlic crop
Authors: Hidayah Baiq Nurul , Herawati Nani , Aisah Ai Rosah , Utami Nita Rizky
Published: March 2021

Abstract. Hidayah BN, Herawati N, Aisah AR, Utami NR. 2021. Diversity of fungi associated with rhizosphere of healthy and diseased garlic crop. Biodiversitas 22: 1433-1440. Garlic (Allium sativum L.) is an especially important horticultural crop in Indonesia because it is used as a cooking spice and for medicines and cosmetic ingredients. It is mostly grown in irrigated highlands; however Indonesian production is only supplying at most 17.5% of domestic demand. West Nusa Tenggara (WNT) Province is one of the largest garlic-producing regions in Indonesia. Currently, garlic cultivation in WNT Province is facing a problem of root rot disease. Therefore, it is necessary to investigate the fungi associated with garlic root rot disease. Research was conducted in June – September 2018 and samples were collected from Sembalun highlands (1200 m above sea level). Seventeen fungal isolates were collected from the rhizosphere of the garlic crops and fourteen of them were identified. The fungi isolated from the rhizosphere of healthy garlic crops were from the genus Aspergillus, Penicillium, and Paecilomyces. While the fungi isolated from the rhizosphere of diseased garlic crops were from the genus Aspergillus, Penicillium, Paecilomyces, Fusarium, and Phoma. The genus Fusarium and Phoma are well known as plant pathogens.
Inhibition of α-glucosidase activity, metals content, and phytochemical profiling of Andrographis paniculata from different geographical origins based on FTIR and UHPLC-Q-Orbitrap HRMS metabolomics
Authors: Rafi Mohamad , SEPTANINGSIH DEWI ANGGRAINI , KAROMAH ALFI HUDATUL , LUKMAN LUKMAN , PRAJOGO BAMBANG , AMRAN MUHAMMAD BACHRI , ROHMAN ABDUL
Published: March 2021

Abstract. Rafi M, Septaningsih DA, Karomah AH, Lukman, Prajogo B, Amran MB, Rohman A. 2021. Inhibition of α-glucosidase activity, metals content, and phytochemical profiling of Andrographis paniculata from different geographical origins based on FTIR and UHPLC-Q-Orbitrap HRMS metabolomics. Biodiversitas 22: 1535-1542. Ensuring consistency of quality, safety, and efficacy of herbal medicines from raw materials to finished products is important because of the variability in medicinal plants' active components. One of the plants that have been used as an antidiabetic herbal medicine is A. paniculata. This study aims to determine α-glucosidase inhibitory activity, the content of several metals, FTIR spectrum profile, and putative identification of A. paniculata metabolites using UHPLC-Q-Orbitrap HRMS from different geographical origin. We found that ethanol extract of A. paniculata gave higher inhibition of α-glucosidase activity compared to water extract. Eight metals were determined using FAAS and FAES, and calcium showed the highest content in all A. paniculata samples. FTIR spectra of A. paniculata showed a similar profile and only differed in the absorbance. We detected the presence of OH, C=O, C=C aromatic, and C-O functional groups in A. paniculata extract. About 32 metabolites were putatively identified in A. paniculata, mainly from phenolic and diterpene lactones class compounds based on UHPLC-Q-Orbitrap HRMS. Using a combination of FTIR spectra and peak area from 32 identified peaks, we can clustered A. paniculata based on its geographical origin. Based on the result obtained, the geographical origin of A. paniculata affected the metals and metabolites composition and level, resulting in different levels of α-glucosidase inhibitory activity.
Molecular identification of coprophilous microfungi from Banyumas District, Central Java, Indonesia
Authors: Mumpuni Aris , Amurwanto Adi , Wahyono Daniel Joko
Published: March 2021

Abstract. Mumpuni A, Amurwanto A, Wahyono DJ. 2021. Molecular identification of coprophilous microfungi from Banyumas District, Central Java, Indonesia. Biodiversitas 22: 1550-1557. Coprophilous microfungi are a group of fungi that are ecologically interesting in relation to herbivores. These fungi play a predominant role in the decomposition of organic matter, in which the organic matter passes through a series of events involving mechanical degradation, as well as physical and biological processes. The role of coprophilous fungi as the main decomposers of the lignocellulosic material of herbivorous animal waste, which is widespread in nature, is very important. Previous research on the inventory and identification of coprophilous fungi in the Banyumas district has been limited to macroscopic genera, so the results have not been able to provide a comprehensive picture of the presence of coprophilous fungi in the region. Identification of the types of microscopic coprophilous fungi that live in herbivorous animal waste, such as lignocellulosic material, is necessary to understand the taxonomy of these fungi. This study aimed to investigate and identify microscopic coprophilous fungi obtained in the Banyumas district of Central Java, Indonesia. Based on the purposive random sampling method, the obtained fungi were analyzed using the molecular methods of DNA isolation, gene amplification, DNA sequencing and phylogenetic analysis of fungal cultures. The following species and genera were identified: Ceriporia lacerata, Trichosporon insectorum, Lentinus squarrosulus, Fusarium sp., Aspergillus sp., and Trichosporon sp.
Growth pattern of three species of Mullets (Pisces: Mugilidae) in Sombreior River, Rivers State, Niger Delta, Nigeria
Authors: Dienye Henry Eyina , Olopade Olaniyi Alaba
Published: March 2021

Length-weight relationships (LWRs) and condition factor are important biological information to assess the growth pattern and wellbeing of fish species influenced by numerous abiotic and biotic factors. To date, no data on the LWRs and condition of mullets in Sombreior River, Niger Delta. Hence, this research was conducted to determine abundance, length–weight relationship and Fulton’s condition factor (K) of three species of fish belonging to family Mugilidae in Sombreior River, Nigeria. There were a total of 248 samples from five sampling stations for a period of months. Fish species were of various sizes ranging from 24.66±0.40 to 26.35±0.26cm in length and 141.41±6.30 to 161.56±5.87g in weight. For the three species, slope (b) values ranged from 2.18 to 2.68 indicating a negative allometric growth of all fish species. The mean condition factor ranged from 0.89±0.03 forsix Mugil cephalus to 0.93±0.03 for Parachelon grandisquamis while the coefficients of determination (R2) of the LWR regressions ranged between 0.64 (Neochelon falcipinnis) and 0.79 (Parachelon grandisquamis). It was concluded that the mullets in the Sombreior River had a negative allometric growth pattern and the condition is showing the species were in good state of well-being since mean K values are  greater than 1.
Effect of vitamin E on the quality of egg bonylip barb fish Osteochilus vittatus (Valenciennes, 1842)
Authors: Tarigan Nurbety , Affandi Ridwan , Meiyasa Firat
Published: March 2021

Bonylip barb Osteochilus vittatus is a local fish species of significant economic value with vast potential in commercial freshwater fish culture. Traditional cultivation methods are currently employed depending on the seeds, although a low hatchery rate is assumed. The purpose of this study, therefore, was to determine the effect of dietary vitamin E on the quality of bonylip barb eggs, with the applied dosage of 0, 125, 250, and 375 mg/kg. Subsequent parameters measured include fecundity, drowned egg percentage, the chemical composition of eggs, and total energy retention. The results showed that several vitamin E doses significantly (P˂0.05) influenced these aforementioned constraints. Furthermore, the application of vitamin E at 375 mg/kg recorded the best dosage to improve egg quality. In addition, the fecundity was estimated at 23.484 grains, and sink egg percentage reached 92.66%, while protein and fat content were 21.43 mg/kg and 27.88%higher compared to the controlled sample. Therefore, It is concluded that the administration of vitamin E in the feed tends to increase egg quality of bonylip barb fish.
A review on several important aspects of the camels
Authors: Khaskheli Asad Ali
Published: March 2021

The present study was conducted to gather the information regarding habitat, population, management, production and economic analysis of the camels worldwide. The main findings of review showed camel population around 25.89 million worldwide in almost 47 countries. Majority of camel herders were reported un-educated. Researchers further indicated that camels generally are reared under sedentary (50%), transhumant (25%), nomadic (15%) and household (10%) management systems. Age of camel famers ranges from 25 to 50 years. The female ratio markedly remains higher than males and young ones because the females are generally used for milk production. However the males are mostly used to carry the luggage, carrying load pulling cart etc. It was also stated by scientists that camels are mostly allowed for open grazing of natural vagetations. Breeding is practiced by natural method and the camel spend 20 to 30 minutes for matting. The female camels reach at the puberty age in 3-5 years, while male at 3.5 to 5.5 years. The duration of estrus cycle in camels vary from 16 to 22 days. Breeding period of camels remain between November and March. The average hair production of camels is 1.63 kg, average daily milk production 6.40 liter. Male have carrying capacity of 553 kg. In conclusion the husbandry practices of camel farming worldwide are based on old traditional methods, however the scientific farming rarely exits. There is no extension services available for the herders to motivate, educate and aware them modern management practices. Market infrastructure, as per study review, is not well established. Mostly the camel herder sale out their animals to middlemen due to long market distances.
Effect of asam kandis (Garcinia cowa Roxb) extract in drinking water on egg quality of Japanese quail (Coturnix coturnix japonica)
Authors: Darmawan Arif , Hermana Widya , Dirgantara Muhamad Prastyo
Published: March 2021

Asam kandis  (Garcinia  cowa  Roxb)  fruit has been reported to contain phytochemicals such as xanthon, hydroxy cytric acid and flavonoids that have various activities such as antimicrobial and antioxidant. This study was aimed  to investigate the effect of asam kandis extract addition in drinking water on the quality of quail eggs. Ninety nine laying quails of 59  days of age were divided into 3 treatments and 3 replications with 11 laying quails in each replication. Completely Randomized Design was used and the treatments were: T1= control  (drinking water without asam  kandis extract), T2= drinking water with asam kandis extract at pH 4, T3= drinking water with asam kandis extract at pH 3. The parameters observed were egg weight, egg shape index, yolk color, yolk percentage, albumen percentage, eggshell percentage,  shell thickness, and haugh unit score. The data obtained were analyzed by Analysis of Variance (ANOVA) and significant  differences among treatments means were tested  by Duncans multiple test. The  the addition of asam kandis extract did not affect (P0.05) on egg weight, egg shape index, yolk color, yolk percentage, albumen percentage, eggshell percentage, and haugh unit score. The addition of asam kandis extract in drinking water at pH 3 significantly (P0.05) increased eggshell thickness compare to that of other treatments. The conclusion was the addition of asam kandis extract in drinking water at pH 3 increased eggshell thickness without decreasing egg quality.
Komposisi biota dasar hasil tangkapan alat garok pada perairan pesisir Kronjo, Tangerang
Authors: Yonvitner Yonvitner , Dahuri Rokhmin , Andi Isdradjad Setyobudi , Boer Mennofatria
Published: March 2021

Garok is a fishing gear that operates at the bottom or surface of the substrate that is caught of various benthic species. The garok gear that operates in sediment, even in the long term can cause changes in the composition of the biota. Because exploitative fishing proses, can cause damage, vulnerability and at the long-term impact to the sustainability of the population. The research was carried out in Kronjo Bay, Tangerang from March to May 2011. The samples were collected from the operation, then determined the species, quantity, and weight of each species. Descriptive statistical analysis and ANOVA were used to determine the significance of the composition between stations and observation times. The caught consist of Placuna placenta, Anadara, Murex, Tellina, and crustaceans which belong to the mollusk and crustacean groups. Statistical analysis did not show a significant difference between the research stations, but it was significantly based on the observation time with Fhit 3,1 and Ftab 1,7. It turned out that the abundance of basic biota was found to be high in April then decreased in May. Likewise, the abundance did not show a significant difference in the location and time of observation. The catch composition on the Kronjo coast is dominated by the gastropod group with an average composition of above 50% per operation.Keywords:GarokCompositionDemersalKronjoCoastalABSTRAKGarok adalah alat tangkap yang dioperasikan di dasar perairan yang menangkap berbagai jenis biota dasar.  Alat garok yang dioperasikan dapat menangkap beragam jenis biota dasar dan dalam jangka lama dapat menyebabkan terjadinya perubahan komposisi biota. Alat tangkap yang bersifat eksploitatif dapat menyebabkan kerusakan, kerentanan sehingga menganggu keberlanjutan populasi secara jangka panjang. Penelitian dari praktek penggunaan alat garok ini dilakukan di Teluk Kronjo Tangerang mulai Maret-Mei tahun 2011. Sampel dikumpulkan secara eskploratif dari operasi alat garok, kemudian tentukan jenis, jumlah dan bobotnya dari setiap jenis.  Analisis statistik deskriptif dan ANOVA digunakan untuk mengetahui perbedaan komposisi antar stasiun dan antara waktu pengamatan.  Hasil tangkapan terdiri dari jenis Placuna placenta, Anadara, Murex, Tellina, dan krustasea yang termasuk kelompok moluska dan krustasea. Analisis statistik tidak menunjukan perbedaan yang nyata antara stasiun penelitian, namun berbeda nyata berdasarkan waktu pengamatan dengan Fhit 3,1 dan Ftab 1,7. Kelimpahan biota dasar ditemukan tinggi pada bulan April kemudian menurun pada bulan Mei.  Begitu juga kelimpahan tidak menunjukan perbedaan yang nyata pada lokasi dan waktu pengamatan. Komposisi tangkapan di pesisir Kronjo didominasi oleh kelompok gastropoda dengan komposisi rata-rata diatas 50% setiap kali operasi.Kata kunci:GarokKomposisiDemersalKronjoPesisir
Kondisi suhu dan salinitas serta korelasinya dengan variabilitas eddy di Perairan Halmahera dan Mindanao
Authors: Suharyo Gadza B.T. , Purba Noir P , Yuliandi Lintang P.S. , Syamsuddin Mega L.
Published: March 2021

The purpose of this study was to determine the dynamics of the waters around Halmahera Eddy (HE) and Mindanao Eddy (ME) both horizontally and vertically. The location of the study is in the Pacific Equator Pacific Waters with embedded at 20 - 10oN and 125o-135o E. The data used were temperature and salinity downloaded from Argo Float data centre and combined with surface currents data from MyOcean. The results showed that the two eddies have different impacts on water conditions. In HE, the characteristics are shown by convergent moving mass of water, increasing surface temperature and decreasing salinity. The characteristics of eddy in these waters indicate the existence of downwelling. In ME the mass of water moves divergently, the condition of the sea surface temperature is lower and the salinity level increases. The characteristics of eddy in these waters indicate upwelling.Keywords:EddiesUpwellingIndonesia ThroughflowArgo floatABSTRAKTujuan dari penelitian ini untuk mengetahui dinamika perairan di sekitar Halmahera Eddy (HE) dan Mindanao Eddy (ME) baik secara horizontal dan vertikal. Lokasi kajian berada di Perairan Pasifik Equator Barat dengan koordinat 2o LS – 10o LU dan 125o BT – 135o BT. Data yang digunakan adalah data suhu dan salinitas dari Argo Float dan data arus permukaan dari MyOcean. Hasil penelitian menunjukan bahwa kedua eddy ini memberikan dampak yang berbeda terhadap kondisi perairan. Di HE, karakteristiknya ditunjukkan dengan massa air yang bergerak secara konvergen, meningkatnya suhu di permukaan dan menurunnya kadar salinitas. Karakteristik eddy di perairan ini menunjukkan adanya downwelling. Di ME massa air bergerak secara divergen, kondisi suhu permukaan lautnya lebih rendah dan kadar salinitasnya meningkat. Karakteristik eddy di perairan ini ini menunjukkan adanya upwelling.Kata kunci:EddiesTaikan airArus Lintas IndonesiaArgo float
Analisis dinamika populasi ikan selar kuning (Selaroides leptolepis) dalam upaya pengelolaan sumberdaya ikan pelagis kecil di perairan Bintan, Provinsi Kepulauan Riau
Authors: Septiyawati Septiyawati , Fauzi Muhammad , Efizon Deni
Published: March 2021

This raw fish is used as fisheries products such as salted fish, grilled fish, fishmeal and surimi. This study aims to analyze mortality and recruitment of yellowstipe scad (Selaroides leptolepis) and the information about management of small pelagic fisheries resources in Bintan Waters. This research was carried out in February-June 2019 at the Barek Motor Fish Landing Area (TPI) with fishing areas in Bintan waters. The number of fish studied was 2.550 with a length of 102-215 mm and a weight of 15-102 gr. The highest recruitment peak occurred in Mei of 18.11% and June of 19.48%. The highest and lowest condition factors are 0.83 and 1.09. The total mortality rate (Z) of yellow strait fish is 4.61 per year with a natural mortality rate (M) of 1.66 per year and the capture mortality rate of 2.95 per year so that the exploitation rate is 0.63. The death of yellowstipe scade in the Bintan Sea most of the caused by fishing activities (F) of 2.95 per year.Keywords:Yellowstipe scad Bintan WatersRecrutmentCondition factorsMortalityABSTRAKIkan selar kuning merupakan salah satu jenis ikan ekonomis penting. Ikan ini banyak dimanfaatkan sebagai bahan baku produk olahan perikanan seperti ikan asin, ikan bakar, pindang, tepung ikan dan surimi. Penelitian ini bertujuan untuk menganalisis, mortalitas dan rekrutmen ikan selar kuning (Selaroides leptolepis) dan informasi tentang pengelolaan sumberdaya ikan pelagis kecil di Perairan Bintan. Penelitian ini telah dilaksanakan bulan Februari-Juni 2019 di Tempat Pendaratan Ikan (TPI) Barek Motor dengan wilayah penangkapan di perairan Bintan. Jumlah ikan yang diteliti 2.550 ekor dengan panjang 102-215 mm dan berat 15-102 gr. Puncak rekrutmen tertinggi terjadi bulan Mei sebesar 18,11% dan Juni sebesar 19,48%,. Nilai tertinggi dan terendah faktor kondisi yaitu 0,82 dan 1,09. Laju mortalitas total (Z) ikan selar kuning 4,61 per tahun dengan laju mortalitas alami (M) 1,66 per tahun dan laju mortalitas penangkapan 2,95 per tahun sehingga diperoleh laju eksploitasi 0,63. Kematian ikan selar kuning di laut Bintan sebagian besar diakibatkan oleh aktivitas penangkapan (F) sebesar 2,95 per tahun.Kata kunci:Ikan selar kuning Perairan Bintan Rekrutmen Faktor kondisi Mortalitas
Komunitas makroinvertebrata bentik di perairan Situ Cibuntu, Jawa Barat
Authors: Ibrahim Aiman , Imroatushshoolikhah Imroatushshoolikhah , Toruan Reliana Lumban , Akhdiana Ira , Lukman Lukman
Published: March 2021

Situ Cibuntu, is one of urban ponds located in Bogor Regency, West Java. With a maximum surface area of 11 ha and maximum depth of 1,20 m, the pond serves as irrigation for nearby agricultural fields and recreational fishing. Located in relatively high urban pressure, the pond is highly affected by domestic, agricultural and industrial inflow which can influence the biotic community such as benthic macroinvertebrate. We studied benthic invertebrate community structure in Situ Cibuntu from October to November 2018 to determine the role of environmental factors on benthic macroinvertebrates. Samples were collected biweekly from five sampling points using an Ekman sediment grab with three replicates. Our study revealed 16 species of benthic macroinvertebrates belonging to four classes including Gastropoda, Bivalvia, Clitellata, and Insecta. Melanoides tuberculata species was found to have the highest abundance with an average abundance of 858 individuals/m2. Shanon-Wiener Diversity Index shows a relatively low diversity ranged from 0.61 to 1.26, while evenness index ranged from 0.36 to 0,66. Simpson Dominance Index ranged from 0.24 to 0.93.Keywords:DominanceCommunityAbundanceDiversityBenthic MacroinvertebratePond CibuntuABSTRAKSitu Cibuntu merupakan salah satu situ urban (urban pond) yang terletak di Kabupaten Bogor, Provinsi Jawa Barat. Situ Cibuntu yang memiliki luas permukaan 2,11 ha dengan kedalaman maksimum 1,20 m dimanfaatkan sebagai sumber irigasi pertanian dan sarana pemancingan ikan. Situ di kawasan perkotaan dapat mengalami tekanan karena pengaruh limbah domestik, pertanian, dan industri yang dapat mempengaruhi komunitas biotik seperti makroinvertebrata bentik. Penelitian ini bertujuan untuk mengetahui komunitas makroinvertebrata bentik di perairan Situ Cibuntu. Penelitian dilakukan pada bulan Oktober hingga November 2018 di lima stasiun pengamatan. Pengambilan sampel dilakukan sebanyak tiga kali dengan interval waktu dua minggu. Sampel makroinvertebrata bentik diambil dari sedimen pada setiap stasiun dengan menggunakan Ekman grab sebanyak tiga kali ulangan. Secara keseluruhan ditemukan 16 spesies makroinvertebrata bentik yang tergolong ke dalam empat kelas meliputi Gastropoda, Bivalvia, Clitellata, dan Insekta. Spesies Melanoides tuberculata memiliki kelimpahan tertinggi dengan nilai rata-rata sebesar 858 individu/m2. Keanekaragaman makroinvertebrata bentik tergolong rendah hingga sedang dengan nilai indeks Shanon Wiener (H’) berkisar 0,61-1,26. Nilai indeks kemerataan Pielou (E) berkisar 0,36-0,66, sedangkan indeks dominansi Simpson (D) berkisar 0,24-0,93.Katakunci:DominansiKomunitasKelimpahanKeanekaragamanMakroinvertebrata bentikSitu Cibuntu
Transient mid-IR nonlinear refraction in air
Authors: Tofighi Salimeh , Munera Natalia , Reichert Matthew , Hagan David J. , Van Stryland Eric W.
Published: March 2021

We use the polarization-sensitive, time-resolved Beam-Deflection technique to measure the nonlinear refraction of air, exciting in both the near and mid-IR and probing in the mid-IR. This gives us the first measurements for air using both excitation and probe in the mid-IR, and we find no dispersion of the bound-electronic nonlinear refractive index, n2,el(λ
p
;λ
e
), assuming, as has been shown earlier, that the nuclear rotational nonlinear refraction is nearly dispersionless. From these data, we can model the pulsewidth dependence of the effective nonlinear refractive index, n2,eff, i.e., as would be measured by a single beam. Interestingly, n2,eff is maximized for a pulsewidth of approximately 0.5 ps. The position of this maximum is nearly independent of pressure while its magnitude decreases with increasing pressure and temperature. From the measurements and modeling, we predict the nonlinear refraction in the atmosphere at different altitudes.
Increasing responsivity-bandwidth margin of germanium waveguide photodetector with simple corner reflector
Authors: Lin Chih-Hsien , Huang Ding-Wei , Shih Tien-Tsorng , Kuo Hao-Chung , Chang Shu-Wei
Published: March 2021

The external bandwidth of germanium waveguide photodetectors (PDs) decreases with the device length due to the load and parasitic effects even if the internal one is less affected. Shortening PDs raises the external bandwidth but lowers the responsivity, introducing a trade-off between the two figures of merits. Here, we present a scheme of waveguide PDs based on total internal reflections of corner reflectors. The reflector can be easily fabricated with the standard photolithography at the end of PDs to efficiently reflect optical power back to germanium for additional absorption, allowing for further size reduction. The structure may render the optimization of PDs more flexible.
Spectral interferometric depth-resolved photoacoustic viscoelasticity imaging
Authors: Du Shumin , Chen Zhongjiang , Xing Da
Published: March 2021

Viscoelasticity is closely related to the physiological characteristics of biological tissues. In this Letter, we propose a novel spectral interferometric depth-resolved photoacoustic viscoelasticity imaging (SID-PAVEI) method, to the best of our knowledge for the first time, which breaks the plight of surface viscoelasticity imaging and achieves an internal visible microscale SID-PAVEI in a noncontact fashion. In this work, we employ a high-sensitive and depth-resolved spectral domain low coherence interferometry (SDLCI) to remotely track photoacoustic-induced strain response of absorbers in situ. By decoupling the phase and amplitude of the photoacoustic-encoded spectral interference signal, the SID-PAVEI and scattering structure imaging (SSI) can be obtained simultaneously. Depth-resolved performance of the SID-PAVEI and the SSI in one scan were demonstrated by imaging biological tissues. The method opens new perspectives for three-dimensional microscale viscoelasticity imaging and provides a great potential in multi-parametric characterizing pathological information.
High-power sub-15  fs nonlinear pulse compression at 515  nm of an ultrafast Yb-doped fiber amplifier
Authors: Descamps Dominique , Guichard Florent , Petit Stéphane , Beauvarlet Sandra , Comby Antoine , Lavenu Loïc , Zaouter Yoann
Published: March 2021

We present an efficient and robust scheme to produce energetic sub-15 fs pulses centered at 515 nm with a peak power exceeding 3 GW. Combining efficient second-harmonic generation of a 135 fs, 50 W Yb-doped fiber amplifier with a low-loss capillary-based visible pulse compression stage, we reach an overall efficiency higher than

>

20

%

. The system is also designed to take advantage of the repetition rate flexibility of the fiber amplifier, leading sub-15 fs pulse generation from 166 to 500 kHz with an average power exceeding the 10 watt level. The combined reduction of the laser wavelength and pulse duration is expected to highly improve the yield of high-order harmonic generation to provide high photon flux of ultrashort extreme ultraviolet radiation.
Blunted diurnal firing in lateral habenula projections to dorsal raphe nucleus and delayed photoentrainment in stress-susceptible mice
Authors: Liu He , Rastogi Ashutosh , Narain Priyam , Xu Qing , Sabanovic Merima , Alhammadi Ayesha Darwish , Guo Lihua , Cao Jun-Li , Zhang Hongxing , Aqel Hala , Mlambo Vongai , Rezgui Rachid , Radwan Basma , Chaudhury Dipesh
Published: March 2021

Daily rhythms are disrupted in patients with mood disorders. The lateral habenula (LHb) and dorsal raphe nucleus (DRN) contribute to circadian timekeeping and regulate mood. Thus, pathophysiology in these nuclei may be responsible for aberrations in daily rhythms during mood disorders. Using the 15-day chronic social defeat stress (CSDS) paradigm and in vitro slice electrophysiology, we measured the effects of stress on diurnal rhythms in firing of LHb cells projecting to the DRN (cellsLHb→DRN) and unlabeled DRN cells. We also performed optogenetic experiments to investigate if increased firing in cellsLHb→DRN during exposure to a weak 7-day social defeat stress (SDS) paradigm induces stress-susceptibility. Last, we investigated whether exposure to CSDS affected the ability of mice to photoentrain to a new light–dark (LD) cycle. The cellsLHb→DRN and unlabeled DRN cells of stress-susceptible mice express greater blunted diurnal firing compared to stress-näive (control) and stress-resilient mice. Daytime optogenetic activation of cellsLHb→DRN during SDS induces stress-susceptibility which shows the direct correlation between increased activity in this circuit and putative mood disorders. Finally, we found that stress-susceptible mice are slower, while stress-resilient mice are faster, at photoentraining to a new LD cycle. Our findings suggest that exposure to strong stressors induces blunted daily rhythms in firing in cellsLHb→DRN, DRN cells and decreases the initial rate of photoentrainment in susceptible-mice. In contrast, resilient-mice may undergo homeostatic adaptations that maintain daily rhythms in firing in cellsLHb→DRN and also show rapid photoentrainment to a new LD cycle.
Combinatorial mathematical modelling approaches to interrogate rear retraction dynamics in 3D cell migration
Authors: Hetmanski Joseph H. R. , Jones Matthew C. , Chunara Fatima , Schwartz Jean-Marc , Caswell Patrick T.
Published: March 2021

Cell migration in 3D microenvironments is a complex process which depends on the coordinated activity of leading edge protrusive force and rear retraction in a push-pull mechanism. While the potentiation of protrusions has been widely studied, the precise signalling and mechanical events that lead to retraction of the cell rear are much less well understood, particularly in physiological 3D extra-cellular matrix (ECM). We previously discovered that rear retraction in fast moving cells is a highly dynamic process involving the precise spatiotemporal interplay of mechanosensing by caveolae and signalling through RhoA. To further interrogate the dynamics of rear retraction, we have adopted three distinct mathematical modelling approaches here based on (i) Boolean logic, (ii) deterministic kinetic ordinary differential equations (ODEs) and (iii) stochastic simulations. The aims of this multi-faceted approach are twofold: firstly to derive new biological insight into cell rear dynamics via generation of testable hypotheses and predictions; and secondly to compare and contrast the distinct modelling approaches when used to describe the same, relatively under-studied system. Overall, our modelling approaches complement each other, suggesting that such a multi-faceted approach is more informative than methods based on a single modelling technique to interrogate biological systems. Whilst Boolean logic was not able to fully recapitulate the complexity of rear retraction signalling, an ODE model could make plausible population level predictions. Stochastic simulations added a further level of complexity by accurately mimicking previous experimental findings and acting as a single cell simulator. Our approach highlighted the unanticipated role for CDK1 in rear retraction, a prediction we confirmed experimentally. Moreover, our models led to a novel prediction regarding the potential existence of a ‘set point’ in local stiffness gradients that promotes polarisation and rapid rear retraction.
PIEZO1 and the mechanism of the long circulatory longevity of human red blood cells
Authors: Rogers Simon , Lew Virgilio L.
Published: March 2021

Human red blood cells (RBCs) have a circulatory lifespan of about four months. Under constant oxidative and mechanical stress, but devoid of organelles and deprived of biosynthetic capacity for protein renewal, RBCs undergo substantial homeostatic changes, progressive densification followed by late density reversal among others, changes assumed to have been harnessed by evolution to sustain the rheological competence of the RBCs for as long as possible. The unknown mechanisms by which this is achieved are the subject of this investigation. Each RBC traverses capillaries between 1000 and 2000 times per day, roughly one transit per minute. A dedicated Lifespan model of RBC homeostasis was developed as an extension of the RCM introduced in the previous paper to explore the cumulative patterns predicted for repetitive capillary transits over a standardized lifespan period of 120 days, using experimental data to constrain the range of acceptable model outcomes. Capillary transits were simulated by periods of elevated cell/medium volume ratios and by transient deformation-induced permeability changes attributed to PIEZO1 channel mediation as outlined in the previous paper. The first unexpected finding was that quantal density changes generated during single capillary transits cease accumulating after a few days and cannot account for the observed progressive densification of RBCs on their own, thus ruling out the quantal hypothesis. The second unexpected finding was that the documented patterns of RBC densification and late reversal could only be emulated by the implementation of a strict time-course of decay in the activities of the calcium and Na/K pumps, suggestive of a selective mechanism enabling the extended longevity of RBCs. The densification pattern over most of the circulatory lifespan was determined by calcium pump decay whereas late density reversal was shaped by the pattern of Na/K pump decay. A third finding was that both quantal changes and pump-decay regimes were necessary to account for the documented lifespan pattern, neither sufficient on their own. A fourth new finding revealed that RBCs exposed to levels of PIEZO1-medited calcium permeation above certain thresholds in the circulation could develop a pattern of early or late hyperdense collapse followed by delayed density reversal. When tested over much reduced lifespan periods the results reproduced the known circulatory fate of irreversible sickle cells, the cell subpopulation responsible for vaso-occlusion and for most of the clinical manifestations of sickle cell disease. Analysis of the results provided an insightful new understanding of the mechanisms driving the changes in RBC homeostasis during circulatory aging in health and disease.
Derivation of the first clinical diagnostic models for dehydration severity in patients over five years with acute diarrhea
Authors: Levine Adam C. , Barry Meagan A. , Gainey Monique , Nasrin Sabiha , Qu Kexin , Schmid Christopher H. , Nelson Eric J. , Garbern Stephanie C. , Monjory Mahmuda , Rosen Rochelle , Alam Nur H.
Published: March 2021

Diarrheal diseases lead to an estimated 1.3 million deaths each year, with the majority of those deaths occurring in patients over five years of age. As the severity of diarrheal disease can vary widely, accurately assessing dehydration status remains the most critical step in acute diarrhea management. The objective of this study is to empirically derive clinical diagnostic models for assessing dehydration severity in patients over five years with acute diarrhea in low resource settings. We enrolled a random sample of patients over five years with acute diarrhea presenting to the icddr,b Dhaka Hospital. Two blinded nurses independently assessed patients for symptoms/signs of dehydration on arrival. Afterward, consecutive weights were obtained to determine the percent weight change with rehydration, our criterion standard for dehydration severity. Full and simplified ordinal logistic regression models were derived to predict the outcome of none (<3%), some (3–9%), or severe (>9%) dehydration. The reliability and accuracy of each model were assessed. Bootstrapping was used to correct for over-optimism and compare each model’s performance to the current World Health Organization (WHO) algorithm. 2,172 patients were enrolled, of which 2,139 (98.5%) had complete data for analysis. The Inter-Class Correlation Coefficient (reliability) was 0.90 (95% CI = 0.87, 0.91) for the full model and 0.82 (95% CI = 0.77, 0.86) for the simplified model. The area under the Receiver-Operator Characteristic curve (accuracy) for severe dehydration was 0.79 (95% CI: 0.76–0.82) for the full model and 0.73 (95% CI: 0.70, 0.76) for the simplified model. The accuracy for both the full and simplified models were significantly better than the WHO algorithm (p<0.001). This is the first study to empirically derive clinical diagnostic models for dehydration severity in patients over five years. Once prospectively validated, the models may improve management of patients with acute diarrhea in low resource settings.
Post-intensive care syndrome as a predictor of mortality in patients with critical illness: A cohort study
Authors: Yanagi Naoya , Kamiya Kentaro , Hamazaki Nobuaki , Matsuzawa Ryota , Nozaki Kohei , Ichikawa Takafumi , Valley Thomas S. , Nakamura Takeshi , Yamashita Masashi , Maekawa Emi , Koike Tomotaka , Yamaoka-Tojo Minako , Arai Masayasu , Matsunaga Atsuhiko , Ako Junya
Published: March 2021

Introduction

The post-intensive care syndrome (PICS) encompasses multiple, diverse conditions, such as physical disability, cognitive impairment, and depression. We sought to evaluate whether conditions within PICS have similar associations with mortality among survivors of critical illness.

Materials and methods

In this retrospective cohort study, we identified 248 critically ill patients with intensive care unit stay ≥72 hours, who underwent PICS evaluation. Patients with disability in activities of daily living, cognitive impairment, or depression before hospitalization were excluded. We defined PICS using established measures of physical disability (usual gait speed), cognitive impairment (Mini-Cog test), and depression (Patient Health Questionnaire-2) at hospital discharge. The endpoint was all-cause mortality.

Results

Patients had a median age of 69 years and Acute Physiology and Chronic Health Evaluation (APACHE) II score of 16. One hundred thirty-two patients were classified as having PICS, and 19 patients died. 81/248 (34%) patients had physical disability, 42/248 (19%) had cognitive impairment, and 44/248 (23%) had depression. After adjusting for covariates on multivariable Cox regression analyses, PICS was significantly associated with all-cause mortality (hazard ratio [HR] 3.78, 95% confidence interval [CI] 1.02 – 13.95; P = 0.046). However, the association between PICS and all-cause mortality was related to physical disability and cognitive impairment (P = 0.001 and P = 0.027, respectively), while depression was not (P = 0.623).

Conclusion

While PICS as a syndrome has been useful in gaining attention to the sequelae of critical illness, its relationship with long-term mortality is driven largely by physical disability and cognitive impairment and not depression.
Societies in balance: Monumentality and feasting activities among southern Naga communities, Northeast India
Authors: Wunderlich Maria , Jamir Tiatoshi , Müller Johannes , Rassman Knut , Vasa Ditamulü
Published: March 2021

Among various Naga communities of Northeast India, megalithic building and feasting activities played an integral role in the different and intertwined dimensions of social and political organisation until very recently. During a collaborative fieldwork in 2016, we visited different village communities in the southern areas of Nagaland and recorded local knowledge about the function and social implications of megalithic building activities. The preserved knowledge of the monuments themselves and their embeddedness in complex feasting activities and social structures illustrate the multifaceted character of megalithic building. The case study of Nagaland highlights how the construction of megalithic monuments may fulfil very different functions in societies characterised by institutionalised hierarchies than in those that have a more egalitarian social organisation. The case study of southern Naga communities not only shows the importance of various dimensions and courses of action–such as sharing and cooperation, competitive behaviour, and the influence of economic inequality–, but also the importance of social networks and different layers of kinship. The multifaceted and interwoven character of megalithic building activities in this ethnoarchaeological case study constitutes an expansion for the interpretation of archaeological case studies of monumentality.