bluuebunny/crossref_metadata_2025 huggingface dataset:
Acquired Partial Lipodystrophy: Clinical Management in a Pregnant Patient
Authors: Romanisio Martina , Bighetti Leonardo , Daffara Tommaso , Mollero Edoardo Luigi Maria , Pelosini Caterina , Antoniotti Valentina , Ciamparini Carola , Aimaretti Gianluca , Caputo Marina , Prodam Flavia
Published: October 2024

Background

Pregnancy represents an additional challenge to the complex clinical picture of lipodystrophy disorders, and the management of such conditions with related comorbidities has been underreported. This work aims to outline the risk associated with a pregnancy event for women dealing with acquired partial lipodystrophy and the need for diverse but specialized care.

Case

We report on the successful pregnancy outcome of a 28-year-old woman with an acquired partial form of lipodystrophy related to an allogenic bone marrow transplant that occurred at pediatric age. Although metabolic control was challenging, glucose levels progressively improved during the pregnancy, and triglycerides increased less than expected. The periodic monitoring of leptin levels showed a progressive increase with a peak in the third trimester (41.53 ng/mL), followed by a fast decline the day after giving birth, with a lower basal level than the prepregnancy period. However, preterm delivery occurred associated with cardiac complications in the mother.

Results

A total of 12 studies were retrieved concerning women aged 14 to 38 years with various lipodystrophy phenotypes. Diabetes and hypertriglyceridemia were the most common comorbidities. Most women had successful pregnancies despite gestational complications (including miscarriages), preterm and emergency deliveries, and newborns undergoing partum or postpartum transient or chronic complications.

Conclusion

Lipodystrophy disorders expose both mothers and children to very high risk. Intensive monitoring and care of all potential clinical complications should be planned and carried out by a multidisciplinary team before, during, and after the pregnancy. Leptin secretion during pregnancy should be investigated more deeply in these patients.
Assessing Neurosurgery Training: Accreditation Council for Graduate Medical Education Case Minimums Versus Surgical Autonomy
Authors: Venkatraman Vishal , Kelly-Hedrick Margot , Suarez Alexander D. , Dharmapurikar Rajeev , Lad Shivanand P. , Haglund Michael M.
Published: October 2024

BACKGROUND AND OBJECTIVES:

The Accreditation Council for Graduate Medical Education (ACGME) requires neurosurgery residents to reach a set number of cases in specified procedure types (case minimums) before graduation and mandates completion of Milestones. We used the Surgical Autonomy Program, a validated method of autonomy-based resident evaluation, to determine the number of cases it took for residents to become competent and compared these with the ACGME case minimums.

METHODS:

We collected data from neurosurgery residents at Duke University on 7 procedures (tumor craniotomy, trauma craniotomy, ventriculoperitoneal shunt, anterior cervical discectomy and fusion (ACDF), posterior cervical fusion (PCF), discectomy/laminectomy, and posterior thoracolumbar spinal fusion [PSF]). We defined competency as being graded at the highest autonomy level in the Surgical Autonomy Program by attending neurosurgeons for the first and second time and determined the case volume on the ACGME case log when these were achieved. These results were analyzed with summary statistics.

RESULTS:

The median case volume among residents (N = 4-8) for the first and second competency rating (and ACGME minimum) for each procedure type was found to be: tumor: 44.5 and 64.5 (min. 60), trauma: 21 and 30 (min. 60), ventriculoperitoneal shunt: 11.3 and 13 (min. 20), ACDF: 30 and 32.5 (min. 20), PCF: 24 and 40 (min. 30), discectomy/laminectomy: 28 and 36 (min. 30), and PSF: 51 and 54 (min. 30).

CONCLUSION:

We found variation in the case numbers to reach competency and that for some procedures (tumor, ACDF, PCF, discectomy/laminectomy, and PSF), most residents required more cases than the ACGME case minimums to achieve competency. The ACGME case minimums may not accurately reflect the number of cases required for neurosurgical residents to reach competency. To promote trainee-centered education, individualized, competency-based evaluation systems may be better determining readiness for graduation, including a system that builds off the established ACGME Milestones.
Early-life cisplatin exposure induces neuroinflammation and chemotherapy-induced neuropathic pain
Authors: Da Vitoria Lobo Marlene , Hardowar Lydia , Valentine Tameille , Tomblin Lucy , Guest Charlotte , Sharma Dhyana , Dickins Benjamin , Paul-Clark Mark , Hulse Richard Philip
Published: October 2024

Chemotherapy-induced neuropathic pain (CINP) is a common adverse health-related comorbidity that manifests later in life in patients with paediatric cancer. Current analgesia is ineffective, aligning closely with our lack of understanding of CINP. The aim of this study was to investigate how cisplatin induces nerve growth factor (NGF)-mediated neuroinflammation and nociceptor sensitisation. In a rat model of cisplatin-induced survivorship pain, cisplatin induced a neuroinflammatory environment in the dorsal root ganglia (DRG), demonstrated by NGF-positive macrophages infiltrating into the DRG. Cisplatin-treated CD11b- and F4/80-positive macrophages expressed more NGF compared to those treated with vehicle control. Mouse primary DRG sensory neuronal cultures demonstrated enhanced NGF-dependent TRPV1-mediated nociceptor activity after cisplatin treatment. Increased nociceptor activity was also observed when cultured mouse DRG neurons were treated with conditioned medium from cisplatin-activated macrophages. Elevated nociceptor activity was inhibited in a dose-dependent manner by an NGF-neutralising antibody. Intraperitoneal administration of the NGF-neutralising antibody reduced cisplatin-induced mechanical hypersensitivity and aberrant nociceptor intraepidermal nerve fibre density. These findings identify that a monocyte- or macrophage-driven NGF–TrkA pathway is a novel analgesic target for adult survivors of childhood cancer.
Πολυκριτήρια μεθοδολογία δυναμικής ανάπτυξης τουριστικών περιοχών
Authors: Φακωτάκης Γεώργιος
Published: October 2024

Η παρούσα διατριβή εξετάζει πώς οι μεθοδολογίες ανάλυσης με πολλαπλά κριτήρια (MCA) μπορούν να εφαρμοστούν στη βιώσιμη διαχείριση του τουρισμού. Ιδιαίτερη έμφαση δίνεται στην αξιολόγηση της ικανοποίησης των επισκεπτών, καθώς αυτή αποτελεί κρίσιμο δείκτη της επιτυχίας ενός τουριστικού προορισμού. Χρησιμοποιώντας τη μέθοδο MUSA και το Εθνικό Πάρκο Σαμαριάς στην Κρήτη ως μελέτη περίπτωσης, η έρευνα αναλύει ποικίλα κριτήρια, με στόχο τον εντοπισμό των παραγόντων που επηρεάζουν τη συνολική εμπειρία των επισκεπτών πράγμα που θα επιτρέψει την κατανόηση της κατάστασης και τη δημιουργία στρατηγικών για τη βελτίωσή της.Τα ευρήματα αναδεικνύουν τη μεταβλητότητα στις προσδοκίες και την ικανοποίηση των επισκεπτών κατά την περίοδο 2018-2022, με ιδιαίτερη αναφορά στον αντίκτυπο της πανδημίας COVID-19. Η ανάλυση δείχνει πώς εξωτερικοί παράγοντες επηρεάζουν τις προτεραιότητες των επισκεπτών και την αντίληψή τους για την εμπειρία στο πάρκο. Η διατριβή υπογραμμίζει τη σημασία της προσαρμοστικής διαχείρισης, ώστε να διατηρούνται υψηλά επίπεδα ικανοποίησης και να ενισχύεται η βιώσιμη ανάπτυξη μέσω της συνεχούς παρακολούθησης και αναπροσαρμογής των στρατηγικών διαχείρισης.
A knowledge graph based remanufacturing equipment resource modeling method.
Authors: Liu Xinlan , Wang Lei , Guo Yuyao , Zhang Binyuan , Xia Xuhui
Published: October 2024

Background The uncertainty and non-standardization of the remanufacturing process result in multi-source heterogeneity of remanufacturing equipment capabilities and knowledge information, which limits the development of informationization and intelligence in remanufacturing. Methods Therefore, we propose a knowledge graph-based modeling method for Remanufacturing Equipment Resource (RMER) information. By analyzing the categories of remanufacturing equipment resources and integrating resource information such as man, machine, material, method, and environment, a unified remanufacturing equipment information model and service capability information model were constructed. Based on the top-down knowledge graph construction process, the RMER semantic association information of the ontology pattern and data layers was extracted and integrated to construct the RMER knowledge graph. Results In this paper, 18 enterprise texts, 50 experience texts and thesis patent texts were selected as the training set, and 2 enterprise texts, 50 experience texts and thesis patent texts were selected as the test set. After multiple rounds of model training, the accuracy rate of entity information extraction reached 91.4%, which proved the accuracy and effectiveness of the model for entity information document extraction. Conclusions This study provides a unified information foundation for mapping and optimizing the resource capabilities of remanufacturing equipment. It can help remanufacturing enterprises to quickly configure equipment resources, and improve the intelligent and automated management level of RMER.
Prevalence of psychological distress: a scientific approach towards the mental health and wellbeing of population during the SARS-COV-2 outbreak
Authors: Tauqir Saman , Shah Inayat , Alsubaie Ahmed , Noreen Sara , Sadaf Shazia , Ali Saqib
Published: October 2024

Background The global challenge of the novel coronavirus has led to an unprecedented downturn, adversely affecting the health and mental wellbeing of communities worldwide. The objective of this study is to assess mental health and psychological distress levels within the general population of Peshawar, Pakistan amidst the ongoing COVID-19 pandemic. Method A cross-sectional online survey was conducted among 715 residents of Peshawar, Pakistan. The questionnaire collected data on demographics, socioeconomic status, and residential area. The Modified K10 Kessler Psychological Distress Scale was used to measure mental well-being. Descriptive statistics, including means and standard deviations, were calculated, and statistical analyses were performed using SPSS (IBM, USA, version 22). Results A total of 715 responses were collected. The comprehensive psychological distress score was identified as 25.55, signifying moderate stress levels. Among the respondents, 53.3% were females, 46.7% had completed a bachelor’s degree, 41% were employed, 78.7% were single, 93.1% were non-smokers, and 69.4% resided in urban areas. The study revealed that both gender (p=0.001) employment status (p=0.018) were linked to a more pronounced psychological impact of the outbreak. Conclusions This study highlights age, gender, employment status, and urbanization as influential factors contributing to psychological distress during the COVID-19 outbreak. As we face the challenges of the new normal, it is essential for policymakers to address these mental health concerns through targeted support and interventions, ensuring that mental health resources are accessible and responsive to the needs of affected populations.
The development of a roadmap for Health Technology Assessment implementation in Moldova
Authors: Surgey Gavin , Curocichin Ghenadie , Garabajiu Maria , Novakovic Tanja , Pana Adrian , Oortwijn Wija
Published: October 2024

Abstract Background Moldova strives for universal health coverage (UHC) and considers health technology assessment (HTA) an important policy instrument to inform the choice of services that should be covered to progressively realize UHC. It plays a key role in determining which technologies are coved, considering various dimensions often including cost-effectiveness, budget impact, and feasibility. This paper reports on work undertaken to develop a roadmap for HTA implementation, using evidence-informed deliberative processes (EDPs) as the guiding framework. Methods Between 2020 and 2022, we undertook several activities that informed the roadmap. We conducted a needs assessment and an assessment of European HTA best practices using a combination of desk research, interviews and surveys. We then conducted a document review of six selected HTA systems, complimented by expert interviews from three neighbouring countries. Results The roadmap provided a suggested HTA process, which included instructions on how to execute the different steps of the EDP framework to enhance the legitimacy of HTA-informed decision-making. The roadmap encompasses several aspects such as how to organize stakeholder involvement, how to identify and operationalize decision criteria, and how to make the decision process transparent. Guidance was given to the country on establishing a legal framework for HTA; a communication strategy; strengthening capacity and leveraging HTA expertise. The country was also given tailored advice on the positioning of the HTA-agency, first as an entity within the Ministry of Health or the National Agency of Public Health but with the long-term vision for it to be independent of any state institution. Conclusions Despite several challenges, including a partial disruption because of the Covid-19 pandemic, the development of the roadmap for HTA implementation was completed and agreed upon by the Ministry of Health in Moldova. This work has helped motivate and support the country in HTA institutionalization.
Prevalence, Characteristics and Risk Factors Analysis of Prediabetes: A Cross-Sectional Study
Authors: Amelia Rina , Harahap Juliandi , Wijaya Hendri , Pase M. Aron , Suryani Widjaja Sry , Saktioto Saktioto
Published: October 2024

Background Prediabetes, a reversible condition before the onset of diabetes, is a significant concern in healthcare globally. The global prediabetes epidemic has emerged and has considerably impacted health expenditures. Various risk factors play important roles in the progression of prediabetes to diabetes. Intensive lifestyle and pharmacological interventions can significantly reduce the risk of diabetes progression. Objective This study aimed to determine the prevalence, characteristics, and risk factors of prediabetes state of Medan in August 2023. Methods The sample consisted of 89 participants. This was an analytical cross-sectional study in the community that met the inclusion and exclusion criteria. The determination of prediabetes is based on the results of blood tests, namely, the examination of fasting blood sugar levels (FBGL), 2-hour postprandial oral glucose tolerance test (OGTT), and hemoglobin A1c (HbA1C). Other examinations included lipid profiling (total cholesterol, HDL-C, LDL-C, and triglycerides). Data processing was performed using SPSS via univariate and bivariate analyses (chi-square test). Results Of the 89 participants, the prevalence of prediabetes based on HbA1c, FBGL and 2-hours OGTT levels was 28.1%, 50.6%, and 28.1%, respectively. 82% of the participants were female, and 53.9% were overweight or obese based on body mass index (BMI). The risk factors for prediabetes were age >64 years, female, physical inactivity, and diastolic blood pressure ≥90 mmHg (p<0.05). Other risk factors such age <45-64 years, consumption of vegetables/fruits, BMI, HDL, LDL, trygliceride, total cholesterol, systolic blood pressure, achantosis nigricans, and waist-hip circumference did not associate significantly (p>0.05). Conclusion This study found that the prevalence of prediabetes was 67.4% in Medan. Age >64 years, female, physical inactivity, and diastolic blood pressure ≥90 mmHg were the most important risk factors for prediabetes.
The macroeconomic determinants of trade openness in Latin American countries: A panel data analysis
Authors: Morán Santamaría Rogger Orlando , Llonto Caicedo Yefferson , Cúneo Fernández Francisco Eduardo , Nikolays Pedro Lizana Guevara , Percy Junior Castro Mejía , Pérez Pérez Milagros Judith , Vela Meléndez Lindon , Montenegro López Moises Elias
Published: October 2024

Background Trade openness shows a positive impact on economic growth, supported by economic theory, and export diversification and economic complexity show a positive dynamic in trade openness in the world; however, a specificity is generated in South American countries. Therefore, the objective of the research is to analyse the macroeconomic determinants of trade openness in Latin American countries. Methods The research approach was quantitative and explanatory using panel data methodology from the databases of the World Bank, Harvard University and the Economic Commission for Latin America and the Caribbean for the period 2000-2020. Results The fixed effects panel data model showed that the variables that had a negative impact on trade openness were GDP, the economic complexity index and the logistic performance index, while the variables that had a positive impact were exports of high-tech products (a proxy for innovation), exports, imports, research and development expenditure and interregional trade in goods. Conclusions Therefore, during the analysis period of 2000-2020 in South America, based on the panel data analysis under fixed effects, a total of 8 countries had a negative impact on trade openness, and only the economies of Chile, French Guiana, and Brazil had a positive impact on trade openness; these economies are characterized by their better performance in the economic complexity index, their higher percentage of budget for research and development expenses, and their trade policies oriented towards the industrialization of their value-added products.
Genotoxic effects in island populations of Cartagena de Indias, Colombia due to environmental exposure to mercury and cadmium
Authors: Cano-Pérez Eder , Gómez-Camargo Doris , Malambo-García Dacia
Published: October 2024

Background Contamination of Cartagena Bay, Colombia with heavy metals such as mercury (Hg) and cadmium (Cd) presents a major environmental and public health concern, particularly for human communities residing on nearby islands and coastal areas. These populations face enhanced exposure risks owing to their traditional fishing practices and continuous interactions with polluted marine environments. This study aimed to evaluate the genotoxic effects of environmental exposure to Hg and Cd in populations from the island zone of the Cartagena district, Bolívar. Methods Ninety-four individuals from the four island communities (study group) and 30 individuals from the urban area of Cartagena (control group) participated in this study. The blood samples were collected to measure total mercury (T-Hg) and Cd concentrations, and a Buccal Micronucleus Cytome (BMCyt) assay was used to evaluate exposure effects. Results Cadmiun levels in the blood of the study group were within the normal range and comparable to those of the control group (p > 0.05). However, the study group exhibited significantly higher T-Hg levels (7.34 μg/L) compared to the control group (2.01 μg/L), surpassing the accepted limit. Moreover, the study group showed a higher incidence of DNA damage and cell death biomarkers (p < 0.05). Additionally, significant correlations were observed between total blood Hg levels and the frequencies of micronuclei, karyorrhexis, and karyolysis. Conclusion These results suggest that island populations of Cartagena are exposed to high levels of Hg and exhibit genotoxic damage, indicating a problem that must be addressed.
Case Report: An exceptional localisation in the thigh of a giant primary subcutaneous hydatid cyst.
Authors: Fekih Aymen , Saadana Jacem , Chaouch Firas , Boughattas Firas , Haddada Ikram
Published: October 2024

Hydatid disease is a zoonotic disease caused by the larval stage of Echinococcus granulosus and is found globally. Although the liver and lungs are the most prevalent sites of involvement, sub-cutaneous hydatid cysts are rare especially in the primary occurrence. Sub-cutaneous hydatid cysts usually are noticed as slow growing, painless, and mobile masses beneath the overlying skin which is usually normal and are generally found on the trunk and proximal extremities. To the best of our knowledge, very few cases of primary subcutaneous hydatid cysts of the thigh have been documented. We present a case of a 30-year-old woman from a rural setting, who has a large, painless swelling on her thigh. Imaging studies confirmed the presence of a primary subcutaneous hydatid cyst, which is an atypical presentation of the disease. The entire lesion was excised surgically without any evidence of recurrence for a long period postoperatively. This case illustrates the difficulty in establishing a diagnosis and the importance of early surgical management in these cases.
testCompareR: an R package to compare two binary diagnostic tests using paired data
Authors: Wilson Kyle J. , Roldán-Nofuentes José A. , Henrion Marc Y.R.
Published: October 2024

Background Binary diagnostic tests are commonly used in medicine to answer a question about a patient’s clinical status, most commonly, do they or do they not have some disease. Recent advances in statistical methodologies for performing inferential statistics to compare commonly used test metrics for two diagnostic tests have not yet been implemented in a robust statistical package. Methods Up-to-date statistical methods to compare the test metrics achieved by two binary diagnostic tests are implemented in the new R package testCompareR. The output and efficiency of testCompareR is compared to the only other available package which performs this function, DTComPair, as well as an open-source program, compbdt, using a motivating example. Results testCompareR achieves similar results to DTComPair using statistical methods with improved coverage and asymptotic performance. Further, testCompareR is faster than the currently available package and requires fewer pre-processing steps in order to produce accurate results. Conclusions testCompareR provides a new tool to compare the test metrics for two binary diagnostic tests compared with the gold standard. This tool allows flexible inputs, which minimises the need for data pre-processing, and operates in very few steps, so that it is easy to use even for those less experienced with R. testCompareR achieves results comparable to those computed by DTComPair, using optimised statistical methods and with improved computational efficiency.
Community-Based Health Information Systems in Africa: A Scoping Review of Data Generation, Utilization, and Community Empowerment
Authors: Kuvuna Beatrice , Nyanchoka Moriasi , Guleid Fatuma , Ogutu Michael , Tsofa Benjamin , Nzinga Jacinta
Published: October 2024

Introduction The community-based health information system (CBHIS) is a vital component of the community health system, as it assesses community-level healthcare service delivery and generates data for community health programme planning, monitoring, and evaluation. CBHIS promotes data-driven decision-making, by identifying priority interventions and programs, guiding resource allocation, and contributing to evidence-based policy development. Objective This scoping review aims to comprehensively examine the use of CBHIS in African countries, focusing on data generation, pathways, utilisation of CBHIS data, community accessibility to the data and use of the data to empower communities. Methods We utilised Arksey and O'Malley's scoping review methodology. We searched eight databases: PubMed, EMBASE, HINARI, Cochrane Library, Web of Science, Scopus, Google Scholar, and grey literature databases (Open Grey and OAIster). We synthesised findings using a thematic approach. Results Our review included 55 articles from 27 African countries, primarily in Eastern and Southern Africa, followed by West Africa. Most of the studies were either quantitative (42%) or qualitative (33%). Paper-based systems are primarily used for data collection in most countries, but some have adopted electronic/mobile-based systems or both. The data flow for CBHIS varies by country and the tools used for data collection. CBHIS data informs policies, resource allocation, staffing, community health dialogues, and commodity supplies for community health programmes. Community dialogue is the most common approach for community engagement, empowerment, and sharing of CBHIS data with communities. Community empowerment tends towards health promotion activities and health provider-led approaches. Conclusion CBHIS utilises both paper-based and electronic-based systems to collect and process data. Nevertheless, most countries rely on paper-based systems. Most of the CBHIS investments have focused on digitisation and enhancing data collection, process, and quality. However, there is a need to shift the emphasis towards enabling data utilisation at the community level and community empowerment.
The genome sequence of the red-crested pochard, Netta rufina (Pallas, 1773)
Authors: O’Brien Michelle F. , Lopez Colom Rosa ,   Natural History Museum Genome Acquisition Lab,   Darwin Tree of Life Barcoding collective,   Wellcome Sanger Institute Tree of Life Management, Samples and Laboratory team,   Wellcome Sanger Institute Scientific Operations: Sequencing Operations,   Wellcome Sanger Institute Tree of Life Core Informatics team,   Tree of Life Core Informatics collective,   Darwin Tree of Life Consortium
Published: October 2024

We present a genome assembly from a female specimen of Netta rufina (the red-crested pochard; Chordata; Aves; Anseriformes; Anatidae). The genome sequence has a total length of 1,167.00 megabases. Most of the assembly (98.76%) is scaffolded into 42 chromosomal pseudomolecules, including the Z and W sex chromosomes. The mitochondrial genome has also been assembled and is 16.62 kilobases in length.
Financial analysis and Management (in Russian and English)
Authors: Vyborova Elena
Published: October 2024

The textbook discusses the methodology and methodology of financial analysis, diagnostics and financial management. The methodological aspects of the analysis of the financial condition of the organization in terms of assessing: liquidity, financial stability, economic insolvency are disclosed. The theoretical issues of financial computing, the basic concepts of financial management are considered. The material on the methodology of financial management of flows, risks, stocks, profits, etc. is presented. It
meets the requirements of the federal state educational standards of higher education of the latest generation.
For students, postgraduates, teachers, employees of the financial and banking sector.
Silage: modern approaches to the conservation of hard-to-harvest plants
Authors: Kosolapova Elena , Kuchin Nikolay , Kosolapov Vladimir
Published: October 2024

The monograph reveals the features concerning the technological aspects of silage production: the composition of the epiphytic microflora of the plant mass, the microbiological processes occurring at each stage of the silage production and storage cycle, and the losses associated with it. A comprehensive analysis of the importance of perennial legumes in forage production is presented, biotechnological features characterizing their inaccessibility are disclosed. The existing methods of increasing the efficiency of silage of high-protein, hard-to-digest feed raw materials are considered, emphasis is placed on more promising approaches. An overview of modern technology for each stage of silo production is presented. The principles of forming the composition of forage harvesting equipment are considered.
It is intended for specialists in the field of feed production, heads of agricultural enterprises of various forms of ownership, farmers and students of agricultural universities.
The McCusker Subjective Cognitive Impairment Inventory (McSCI): a
novel measure of perceived cognitive decline – a Korean
translation
Authors: Sohrabi Hamid R. , Gavett Brandon E. , Weinborn Michael , Speelman Craig P. , Bucks Romola S. , Martins Ralph N.
Published: October 2024

Objectives: 주관적 인지 저하(subjective cognitive decline, SCD)는 객관적인 중대한
저하의 증거 없이 자신의 인지 기능에 대한 자기 또는 타인의 우려를 의미하며, 이는 치매 위험의 지표이다. 현재 사용 가능한 SCD 측정 도구의
신뢰도와 타당성에 대한 합의가 부족하다. 따라서 새로운 심리측정학적으로 타당한 SCD 측정 도구를 도입하는 것이 시급하다. 새로운 SCD 측정
도구인 맥커스커 주관적 인지 장애 자가보고서(McCusker Subjective Cognitive Impairment Inventory,
McSCI-S)의 심리측정학적 특성을 보고한다.
Methods: 기존에 출판된 측정 도구의 검토와 SCD를 가진 사람들에 대한 임상 및 연구 데이터를 바탕으로, 기억력,
언어능력, 지남력, 주의력 및 집중력, 시공간 구성 능력 및 실행 기능의 6가지 인지 영역에 대한 우려를 평가하기 위한 46문항 자가보고
설문지를 개발했다. McSCI-S를 526명의 참가자를 대상으로 요인 분석, 문항 반응 이론(item response theory) 분석 및
의사결정 기준점(receiver operating characteristic) 곡선을 통해 검증하였다.
Results: 단일차원 모델(unidimensional model)이 적합한 것으로 나타났다(comparative fit
index=0.94, Tucker–Lewis index=0.94, root mean square error of approximation[90%
CI]=0.052[0.049, 0.055], weighted root mean square residual=1.45). McSCI-S의 내적
일관성은 우수했다(α=0.96). SCD를 가진 참가자를 식별하기 위해 ≥24의 기준 점수(cut-off value)를 제안한다. McSCI-S
점수가 높을수록 연령, 성별 및 교육 수준을 통제한 후에도 전반적인 인지 기능, 일화적 언어 기억력, 실행 기능의 저하 및 더 큰 기억력 불만
및 우울 점수와 관련이 있었다(P<0.001).
Conclusion: 우수한 신뢰도와 구성 타당성은 McSCI-S가 다양한 인지 영역에 대한 자가보고
우려(self-reported concerns)를 포착하면서 SCD를 정확하게 추정함을 시사한다. 심리측정학적 분석은 이 측정 도구가 코호트
연구뿐만 아니라 개인별 임상 환경에서도 SCD를 평가하는 데 사용할 수 있음을 나타낸다.
EFX: A Simpler Approach and an (Almost) Optimal Guarantee via Rainbow Cycle Number
Authors: Akrami Hannaneh , Alon Noga , Chaudhury Bhaskar Ray , Garg Jugal , Mehlhorn Kurt , Mehta Ruta
Published: October 2024

A Simpler Approach to the EFX Problem

Envy-freeness up to any item (EFX) has emerged as a compelling fairness notion in discrete fair division. However, its existence remains one of the biggest open problems in the field. In a breakthrough, Chaudhury et al. (2020) establish the existence of EFX allocations for three agents with additive valuations through intricate case analysis. The paper “EFX: A Simpler Approach and an (Almost) Optimal Guarantee via Rainbow Cycle Number” by Akrami, Alon, Chaudhury, Garg, Mehlhorn, and Mehta offers a simpler approach for improving the EFX guarantee. They demonstrate the existence of EFX allocations for three agents when at least one has additive valuations (whereas the other two have general monotone valuations). Additionally, they nearly resolve a conjecture regarding the rainbow cycle number, leading to an (almost) tight bound for the existence of approximate EFX allocations with few unallocated items achievable through this approach.
Morphology and COI barcodes reveal local loaches (Nemacheilus spp.) from Pasuruan River, East Java, Indonesia
Authors: SULUNG CAHYA AJENG VALENTA TRESNA , CHAIR NISZAMUDDIN EL , RAHAYU DWI ANGGOROWATI , NUGROHO ENDIK DENI , RUSDIANTO RUSDIANTO
Published: October 2024

Abstract. Sulung CAVT, Chair NE, Rahayu DA, Nugroho ED, Rusdianto. 2024. Morphology and COI barcodes reveal local loaches (Nemacheilus spp.) from Pasuruan River, East Java, Indonesia. Biodiversitas 25: 2806-2819. The family Nemacheilidae is one of the most diverse and widespread family of freshwater fishes. The nemacheilid loach in the Pasuruan river is relatively abundant; however, there is limited information available about this species. Therefore, further research is necessary to identify loaches from the Pasuruan area. This research aimed to identify the local loach species from Pasuruan District. The pectoral fins were stored in pure-grade ethanol and subjected to DNA extraction, polymerase chain reaction (PCR), and sequence analysis using bioinformatics tool, BOLD systems, and Automatic Barcode Gap Discovery (ABGD) web. The morphological identification revealed two local loaches, Nemacheilus chrysolaimos Valenciennes 1846 and Nemacheilus fasciatus Valenciennes 1846. The high haplotype diversity (Hd) of 0.9 and nucleotide diversity (?) of 0.1 indicate a wide range of genetic variations. The frequency of parsimony informative sites at 25.6% and 16 polymorphic sites and the overall ts/tv ratio of 2.3. The phylogenetic trees demonstrated a clear and unambiguous branching pattern for N. fasciatus and N. chrysolaimos forming their own monophyletic branches. Kimura's 2-parameter genetic distance of the COI gene sequences between these two species was 0.11. This finding was strengthened by morphological and molecular identification results, which indicated that there are two local loach species in Pasuruan District.
Assessing the resilience of coral reefs against macroalgae invasion in the Sempu Island Nature Reserve, Malang District, Indonesia
Authors: ISDIANTO ANDIK , YORARIZKA PUTRI DEVI , ALIVIYANTI DIAN , SARI SYARIFAH HIKMAH JULINDA , YANUAR ADI TIYA , ASADI MUHAMMAD ARIF , SETYANTO ARIEF , BINTORO GATUT , LELONO TRI DJOKO , ATIKAWATI DINI , FATHAH AULIA LANUDIA , PUTRI BERLANIA MAHARDIKA , SUPRIYADI SUPRIYADI , LUTHFI OKTIYAS MUZAKY
Published: October 2024

Abstract. Isdianto A, Yorarizka PD, Aliviyanti D, Sari SHJ, Yanuar AT, Asadi MA, Setyanto A, Bintoro G, Lelono TD, Atikawati D, Fathah AL, Putri BM, Supriyadi, Luthfi OM. 2024. Assessing the resilience of coral reefs against macroalgae invasion in the Sempu Island Nature Reserve, Malang District, Indonesia. Biodiversitas 25: 2877-2887. The living coral cover in the Sempu Strait is known to be stuck in the range of 37% due to average data from 2009-2016. Several coral diseases have been documented in this region, which can result in the transformation of coral reefs into algae-dominated communities. This study examines the dynamic interplay between coral reefs and macroalgae within the marine ecosystems of the Sempu Island Nature Reserve, Malang District, Indonesia. Conducted across five research stations, our analysis utilized the Underwater Photo Transect (UPT) method, combined with image analysis tools CPCe and Image-J, and statistical analysis through SPSS. The findings indicate a persistent competition between corals and macroalgae, exacerbated by sedimentation from port activities and river discharges, and significant nutrient loads from human settlements. The average living coral coverage varied significantly, with a range from 12% to 53% across the study period, while macroalgae coverage showed an increase, especially in turf algae. The correlation analysis revealed a 'quite strong' relationship (r=0.783 between coral and macroalgae coverage, suggesting that increases in coral cover could potentially facilitate macroalgae proliferation under current environmental conditions. Notably, the study highlighted the critical role of water quality parameters such as temperature, pH, and salinity, which were within optimal ranges yet facilitated competitive interactions. This research underscores the complexity of coral-macroalgae relationships and the pressing need for integrated management strategies focusing on water quality and habitat preservation to ensure the resilience of these critical marine ecosystems.
The diversity and traditional use of home garden plants near Kerinci Seblat National Park, Indonesia
Authors: SUWARDI ADI BEJO , NAVIA ZIDNI ILMAN , MUBARAK ALBIAN , RAHMAT RODIYATUL , CHRISTY PANJI , WIBOWO SARA GUSTIA , IRAWAN HERI
Published: October 2024

Abstract. Suwardi AB, Navia ZI, Mubarak A, Rahmat R, Cristy P, Wibowo SG, Irawan H. 2024. The diversity and traditional use of home garden plants near Kerinci Seblat National Park, Indonesia. Biodiversitas 25: 3284-3299. Home gardens are traditional agroforestry systems that improve plant diversity and ecosystem services while also having a direct and beneficial effect on human well-being. Each plant species in a home garden provides a variety of ecosystem services, which are linked to specific ecological functions and social drives. Although home gardens are biodiversity hotspots and have recently been identified as essential to tropical biodiversity conservation, the benefits of ecosystem services offered by home gardens are frequently undervalued. This study aims to analyze the diversity, usage, and traditional knowledge of home garden plants among the local communities living near Kerinci Seblat National Park, Indonesia. This study was carried out in four villages from two districts of Bengkulu Province, Indonesia, i.e. Lebong and Rejang Lebong. Field surveys, plant collections, and interviews with local communities were used in this study. Interviews were conducted with 120 informants (30 in each village) selected at random. A total of 218 plant species belonging to 67 families associated with 12 use categories were recorded in the study area. Capsicum frutescens, Musa x paradisiaca, and Mangifera indica are frequently discovered in home gardens. The most diverse categories of plant use in home gardens encompass food, medicine, and ornament, utilizing various parts such as rhizomes, leaves, flowers, and fruits. Home gardens, with their diverse plant species, are considered to have a significant role in household livelihoods, protecting plant genetic resources, and biodiversity conservation.
Inverse problem for subdiffusion equation with fractional Caputo derivative
Authors: Ashurov Ravshan Radzhabovich , Shakarova Marjona Dilshoq qizi
Published: October 2024

We consider an inverse problem on determining the right-hand side of the subdiffusion equation with the fractional Caputo derivative. The right-hand side of the equation has the form $f(x)g(t)$ and the unknown is the function $f(x)$. The condition $ u (x,t_0)= \psi (x) $ is taken as the over-determination condition, where $t_0$ is some interior point of the considered domain and $\psi (x) $ is a given function. By the Fourier method we show that under certain conditions on the functions $g(t)$ and $\psi (x) $ the solution of the inverse problem exists and is unique. We provide an example showing the violation of the uniqueness of the solution of the inverse problem for some sign-changing functions $g(t)$. For such functions $g(t)$ we find necessary and sufficient conditions on the initial function and on the function from the over-determination condition, which ensure the existence of a solution to the inverse problem.
Solvability of nonlinear boundary value problems for non-sloping Timoshenko-type isotropic shells of zero principal curvature
Authors: Timergaliev Samat Nizametdinovich
Published: October 2024

We study the solvability of boundary value problem for a system of second order partial differential equations under boundary given conditions describing the equilibrium of elastic non-sloping isotropic inhomogeneous shells with free boundary in the framework of the Timoshenko shear model. The base of the study method are the integral representations for generalized motions involving arbitrary functions, which also involve arbitrary holomorphic functions. The arbitrary functions ate determined so that the generalized motions satisfy a linear system of equations and linear boundary conditions extracted from the original boundary value problem. The holomorphic functions are sought as Cauchy type integrals with real densities. The integral representations allow us to reduce the initial boundary value problem to a nonlinear operator equations for generalized motions in the Sobolev space. While studying the solvability of this operator equation, the most essential point is to invert it with respect to the linear part. As a result, the work is reduced to an equation, the solvability of which is established on the base of the contracting mapping principle.
On density of polynomials in algebra of holomorphic functions of exponential type on linear Lie group
Authors: Aristov Oleg Yurevich
Published: October 2024

The question of the density of the algebra of polynomials (regular functions) in the algebra of holomorphic functions of exponential type on a complex Lie group arose in the study of duality for Hopf algebras of holomorphic functions. It was shown by the author in [J . Lie Theory, 29:4, 1045 - 1070 (2019)] that the answer is affirmative in the connected linear case. However, the argument is quite involved and here we present a short proof. It contains two ingredients. The first is the existences of a finite - dimensional faithful holomorphic representation with closed range. To prove it, we use an approach developed by Ðjoković. The second is a lower bound for the norm of a one - parameter matrix subgroup, which is based on some elementary linear algebra consideration. The rest of the proof is close to the original one and uses a decomposition of the group into a semidirect product of a simply connected solvable and linearly complex reductive factors.
From the garden to the grave – three dark sites related to the legend of Pedro and Inês
Authors: Pascoal Sara , Tallone Laura , Furtado Marco
Published: October 2024

By combining an interpretive reading of the spaces, a study of DMOs marketing strategies and TripAdvisor ratings, this research aims to understand the role of literary constructions, symbols, and discourses in the development, positioning, and management of a dark literary site. Three specific places will be highlighted in relation to the biography of the legend of King Pedro I and Inês de Castro, the "skeleton queen", assessing how these heritage sites exploit the legend for place branding, attracting visitors and creating a strong identity. In addition, this article aims to evaluate how and to what extent three heritage sites—Santa Clara a Velha's Church, Quinta da Lágrimas in Coimbra, and Alcobaça Monastery—associate themselves with the legend of Pedro and Inês, in order to increase their attractiveness, concluding that all the literary resonances of these locations can be traced to Luís Vaz de Camões’ The Lusiads. As for the dark elements, while Quinta das Lágrimas and Alcobaça Monastery combine literary with a macabre appeal, notably Alcobaça, the darkest of the three, Santa a Clara a Velha's Church is primarily of a biographic nature. Additionally, the macabre use of the space in this case appears to overpower the literary associations.
A New Gastronomic Route Encompassing Oleo Tourism and Wine Tourism Along the Olive Corridor of South Marmara in Türkiye
Authors: Çevik Samet , Yıldırım Saçılık Melahat
Published: October 2024

This study aims to assess the potential of oleo tourism and wine tourism within the Olive Corridor of South Marmara, one of the seven thematic tourism development corridors identified in the 2007 action plan, as part of the Türkiye Tourism Strategy 2023. Within the scope of this study, a holistic approach was taken towards the Olive Corridor of South Marmara, presenting a proposed route that encompasses oleo tourism and wine tourism products. The suggested route demonstrates that the corridor holds strong potential in terms of oleo tourism and wine tourism products, and it also possesses rich resources for destination experiences, including landscapes, cultural heritage, and outdoor activities. However, one of the findings of this study is that the corridor has room for development in terms of oleo tourism and wine tourism and should be diversified with new tourism products. Collaborations, support, incentives, marketing efforts, and contributions from producers and the local community, along with a sustainable tourism approach, have the potential to transform the corridor into a strong destination for oleo tourism and wine tourism.
Field of view-independent detection of secondary mirror position errors in coaxial reflecting space telescopes using deep learning
Authors: Wang Wei , Zhang Xiaofang , Jiang Renliang , He Zhonghai
Published: October 2024

The operation of coaxial reflecting space telescopes in orbit is affected by adjustments and space disturbance, causing position errors in the secondary mirror (SM), which reduce resolution and seriously affect imaging quality. Most existing methods for detecting SM position errors rely on wavefronts or images obtained from one or more fixed field of views (FOVs), yet the inherent uncertainty of the FOV can lead to significant errors in detecting SM position errors. To address this problem, this paper, believed to be the first, proposes an FOV-independent SM position error detection method for coaxial reflecting space telescopes based on a pair of symmetric positive and negative defocus point spread functions (PSFs) and the dual-branch convolutional neural network (DB-CNN). First, a nonlinear relationship between the SM position errors and the PSFs at arbitrary FOV is established, using the DB-CNN. Then, the method using a pair of symmetric positive and negative defocus PSFs at arbitrary FOV to obtain the position errors of the SM is proposed, and the simulation results show that, despite the uncertainty of the FOV, the SM position errors can be detected with high precision. This approach enables SM position error correction independent of the FOV, significantly enhancing the imaging quality. Finally, a modified method is proposed to address the problem caused by the primary mirror (PM) figure errors. Simulations prove that the SM position errors can be accurately obtained even in the presence of PM figure errors.
Simultaneous 2-photon and 3-photon excitation with a red fluorescent protein-cyanine dye probe pair in the 1700-nm excitation window for deep in vivo neurovascular imaging
Authors: Xia Fei , Sinefeld David , Chang Zong , Gong Xiaojing , Sun Qinchao
Published: October 2024

In vivo imaging of the neurovascular network is considered to be one of the most powerful approaches for understanding brain functionality. Nevertheless, simultaneously imaging the biological neural network and blood vessels in deep brain layers in a non-invasive manner remains to a major challenge due to the lack of appropriate labeling fluorescence probe pairs. Herein, we proposed a 2-photon and 3-photon fluorescence probe pair for neurovascular imaging. Specifically, the red fluorescence protein (RFP) with an absorption maximum of around 550 nm is used as a 3-photon excited probe to label neurons, and a cyanine derivative dye Q820@BSA has a NIR absorption maximum of 825 nm as a 2-photon excited probe to label the vasculature, enabling single wavelength excitation at 1650 nm for neurovascular imaging with high emission spectral separation (>250 nm). In particular, the 2-photon action cross-section of Q820@BSA was found to be about 2-fold larger than that of indocyanine green (ICG), a commonly used red 2-photon fluorescence labeling agent, at the same excitation wavelength. Benefiting from the long wavelength advantage in reducing scattering in both 2 and 3-photon excitation of the fluorescence pairs, we demonstrated in vivo neurovascular imaging in intact adult mouse brains through white matter and deep into the hippocampus in the somatosensory cortex.
Accurate attenuation characterization in optical coherence tomography using multi-reference phantoms and deep learning
Authors: Peng Nian , Xu Chengli , Shen Yi , Yuan Wu , Yang Xiaoyu , Qi Changhai , Qiu Haixia , Gu Ying , Chen Defu
Published: October 2024

The optical attenuation coefficient (AC), a crucial tissue parameter indicating the rate of light attenuation within a medium, enables quantitative analysis of tissue properties and facilitates tissue differentiation. Despite its growing clinical significance, accurate quantification of AC from optical coherence tomography (OCT) signals remains a pressing concern. This study comprehensively investigates the factors influencing the accuracy of quantitative AC extraction among existing OCT-based AC extraction algorithms. Subsequently, we propose an approach, the Multi-Reference Phantom Driven Network (MR-Net), which leverages multi-reference phantoms and deep learning to implicitly model factors affecting OCT signal propagation, thereby automatically regressing AC. Using a dataset from Intralipid and silicone-TiO2 phantoms with known AC values obtained from a collimated transmission system and imaged with a 1300 nm swept-source OCT system, we conducted a thorough comparison focusing on data length, out-of-focus distance, and reference phantoms’ attenuation among existing OCT-based AC extraction algorithms. By leveraging this extensive dataset, MR-Net can automatically model the complex physical effects in the transmission process of OCT signals, significantly enhancing the accuracy of AC predictions. MR-Net outperforms other algorithms in all metrics, achieving an average relative error of only 10.43% for calculating attenuation samples, significantly lower than the lowest value of 23.72% achieved by other algorithms. This method offers a quantitative framework for disease diagnosis, ultimately contributing to more accurate and effective tissue characterization in clinical settings.