bluuebunny/crossref_metadata_2025 huggingface dataset:
Heterogeneous diffuse large B-cell lymphoma: accurate diagnosis as a key to successful therapy. A review
Authors: Babicheva Lali G. , Poddubnaya Irina V.
Published: August 2023

Diffuse large B-cell lymphoma (DLBCL) is the most common variant of non-Hodgkin's lymphoma and accounts for about 1/3 of all non-Hodgkin's lymphomas in Western countries and about 40% of B-cell tumors worldwide. Correct diagnosis of clinically distinct subgroups of aggressive mature B-cell lymphomas is crucial for the choice of adequate treatment. Currently, the identification of DLBCL subtype depends on a combination of morphologic, immunophenotypic, and cytogenetic/molecular features. The classification covers the most common unspecified variant of DLBCL, also referred to as "not otherwise specified" (NOS), and a number of other rare forms. Over the past two decades, DLBCL NOS which accounts for more than 80% of all cases, has been the subject of a growing number of molecular studies that have identified prognostic factors that are being actively introduced into real-world clinical practice. Only the integration of morphological, immunohistochemical and molecular features of DLBCL will lead to the achievement of the long-term goal of curing the majority of patients with minimal or no toxic manifestations with the aid of personalized healthcare.
Safety and toxicity of cabozantinib monotherapy in patients with advanced renal cell carcinoma: a Russian multicenter observational study
Authors: Volkova Maria I. , Kalpinskiy Alexey S. , Menshikov Konstantin V. , Gorbuleva Lilia V. , Sultanbaev Alexander V. , Evsyukova Olga I. , Meltonian Varazdat R. , Mishugin Sergey V. , Maturov Mikhail R. , Olshanskaya Anna S. , Shemetov Dmitrii Iu. , Sannikova Tatyana A. , Makhnutina Mariia V. , Filipieva Marina A. , Gaijsina Elena A. , Ovchinnikova Elena G. , Mailian Ovsep A. , Alekseev Boris Ya. , Matveev Vsevolod B.
Published: August 2023

Aim. To assess the safety and to analyze an influence of cabozantinib monotherapy toxicity on treatment efficacy in unselected Russian patients with metastatic renal cell carcinoma (mRCC).
Materials and methods. Medical data of 92 patients with verified mRCC were included in the study. The median age of the patients was 56 (1979) years, most of them - 60 (65.2%) were of male gender. Twenty five (27.2%) persons had Eastern Cooperative Oncology Group performance status (ECOG PS). At the time of cabozantinib monotherapy start 5 (5.4%) patients had favorable, 54 (58.7%) intermediate, and 33 (35.9%) unfavorable prognosis by International Metastatic Renal Cancer Database Consortium (IMDC) model. Eighty-three (90.2%) patients were pretreated, including 76 (82.6%) patients who previously received anti-angiogenic agents. All patients were administered with cabozantinib monotherapy (60 mg/day); dose adjustment was performed according to the instruction.
Results. Adverse events (AEs) were reported in 81 (88.0%) of 92 patients; 30 (32.6%) AEs were grade 34. Toxicity-related dose reduction of cabozantinib was required in 28 (30.4%), treatment interruption in 15 (16.3%), and discontinuation in 2 (2.2%) patients. The most common AEs were hypertension (69 patients, 75.0%), asthenia (47 patients, 51.1%), diarrhea (43 patients, 46.7%), and palmar-plantar erythrodysesthesia (43 patients, 46.7%). The most common severe AEs were: arterial hypertension (17 patients, 18.5%), diarrhea (6 patients, 6.5%), and palmar-plantar erythrodysesthesia (2 patients, 2.2%). The most frequent laboratory abnormalities during therapy were elevated serum transaminases (33 patients, 35.9%), anemia (13 patients, 14.1%), and thrombocytopenia (10 patients, 10.9%). No previously unreported AEs or laboratory abnormalities were observed. There was a significant increase in progression-free survival (hazard ratio 2.5; 95% confidence interval 1.05.9; p=0.046) and overall survival (hazard ratio 3.0; 95% confidence interval 1.28.3; p0.025) in patients with treatment-related arterial hypertension.
Conclusion. The observational study confirmed the acceptable safety profile of cabozantinib in the first and subsequent lines of treatment in mRCC patients. No new safety signals were identified. Treatment-related arterial hypertension may be a favorable predictor of survival.
The effect of hormonal contraception on the risk of breast cancer: A review
Authors: Iurova Mariia V. , Mezhevitinova Elena A. , Yakushevskaya Oksana V. , Rodionov Valerii V. , Prilepskaya Vera N.
Published: August 2023

Hormonal-induced changes in the breast occur due to both endogenous and exogenous sex hormones. For two decades, the safety of hormonal contraceptives (HC) in terms of their effect on breast tissue has been discussed in the literature. The pleiotropic effect of the components in the combined HC, on the one hand, prevents unwanted pregnancy; on the other hand, they help to maintain good health of women of childbearing age due to a wide range of non-contraceptive effects (eliminating hyperandrogenism manifestations, reducing the pain severity during menstruation and the menstrual blood loss, the risk of recurrence of functional ovarian cysts, oncoprotective effect due to reducing the risk of ovarian, endometrial, colorectal, pancreatic, and lung cancer). However, according to epidemiological studies, in addition to the beneficial effects, there are risks that require further study, including the controversial impact of HC on the oncogenesis and progression of breast cancer. In addition, some young women with breast cancer experience induced menopause after antitumor treatment. However, amenorrhea is not a marker for complete disabling of ovarian function, and pregnancy is associated with a risk of disease recurrence or progression. Therefore, in each case, it is necessary to determine the need for an effective and safe method of contraception.
Squamous cell carcinoma of the skin after cardiac transplantation: a clinical case
Authors: Ognerubov Nikolai A. , Ognerubova Marina A.
Published: August 2023

Background. Solid organ transplantation recipients have a high risk of non-melanoma skin tumors. Patients after heart transplantation are prone to a higher incidence of malignant skin tumors due to intensive immunosuppressive therapy. The most common histological type is squamous cell carcinoma, followed by basal cell carcinoma. These tumors have a more aggressive clinical course, including the frequency of recurrence and metastasis, and a tendency to multifocal lesions.
Materials and methods. We present a clinical case of primary multiple squamous cell carcinoma with metastatic lesions of regional lymph nodes in a patient after heart transplantation.
Results. A 67-year-old patient underwent an orthotopic heart transplant in September 2018 for ischemic cardiomyopathy. Subsequently, triple immunosuppressive therapy was administered, including tacrolimus combined with mycophenolate mofetil and prednisolone. In May 2022, a solid tumor with ulceration occurred on the skin of the right scapular region. After some time, similar tumors appeared on the skin of the temporal region on the left, the posterior surface of the auricle and the parietal region on the left. The patient later found a solid, painless tumor on the left jaw angle. As a part of the examination in the oncology dispensary, a biopsy of the scapular skin tumor, scrapings from tumors, and aspiration biopsy of the submandibular lymph nodes were performed. Histological and cytological studies of all neoplasms showed squamous cell keratinizing cancer with metastases to the submandibular lymph nodes. Additional examination methods showed no signs of progression. The diagnosis was made: primary multiple synchronous skin cancer: right scapular area, stage III, cT3N0M0; left parietal area, stage II, cT2N0M0; occipital area, stage I, cT1N0M0; left auricle, stage IV, cT1N2M0. Considering the localization of tumors, surgical treatment was performed, including of excision of tumors in the scapular and parietal regions. Radiation therapy was performed on lymph nodes with metastases. After 6 months, a tumor recurrence was detected in the irradiation area.
Conclusion. After heart transplantation, squamous cell carcinoma of the skin is common. Usually, it affects the scalp and neck with metastases to the regional lymph nodes and is prone to recurrence. The primary treatment method is surgical and radiation therapy.
Cardiovascular outcomes of dapagliflozin in type 2 diabetes mellitus in real clinical practice: a meta-analysis of observational studies
Authors: Antsiferov Mikhail B. , Demidov Nikolay A.
Published: August 2023

Aim. To conduct a meta-analysis of population-based observational studies of dapagliflozin compared with therapy without iNGLT-2 to assess its effect on the risk of cardiovascular events in patients with type 2 diabetes mellitus in real-world practice.
Materials and methods. A systematic search was carried out in 3 bibliographic databases PubMed (Medline), Embase and eLibrary. According to the search results, 1,451 records were identified. 3 studies were selected for inclusion in the meta-analysis: CVD-REAL Nordic, EASEL Population-Based Cohort Study and CARDIA-MOS. The criteria for evaluating the effectiveness were the frequency of major adverse cardiovascular events (MACE) and cardiovascular mortality. The meta-analysis was carried out in the RevMan 5.4.1.
Results. According to the results of the meta-analysis, there was a statistically significant association between the use of dapagliflozin and a decrease in the risk of MACE: relative risk 0.73, 95% confidence interval 0.650.82, as well as a decrease in cardiovascular mortality: relative risk 0.67, 95% confidence interval 0.480.92.
Conclusion. Our results demonstrated that the use of dapagliflozin is associated with a reduction in the risk of developing MACE and cardiovascular mortality in patients with type 2 diabetes mellitus with cardiovascular diseases or cardiovascular risk factors.
Safety of dapagliflozin initiation in acute decompensated heart failure patients with reduced left ventricular ejection fraction
Authors: Poskakalova Anastasiya E. , Nasonova Svetlana N. , Zhirov Igor V. , Tereshchenko Sergey N.
Published: August 2023

Background. Chronic heart failure (CHF) is an immediate cardiological problem. At the same time, acute decompensated heart failure (ADHF) is associated with an extremely unfavorable prognosis and low survival of patients.
Aim. To evaluate the safety of sodium-glucose cotransporter-2 inhibitor dapagliflozin early administration in patients with ADHF with a reduced left ventricular ejection fraction (LVEF) regardless of type 2 diabetes mellitus (diabetes).
Materials and methods. We used standard CHF therapy and intravenous diuretic therapy in combination with 10 mg dapagliflozin in 43 patients with NYHA class IIIV ADHF. The study mainly included 39 (90.7%) male patients, the mean age was 6012 years (5663), diabetes was in 14 (32.6%) patients. Dapagliflozin was prescribed by a mean of 2 days (13) from admission to the hospital. The parameters were analyzed at the time of inclusion in the study and when CHF compensation was achieved.
Results. The median of the length of hospital stay was 7 days (610). LVEF significantly increased during hospitalization from 276 to 307% (p0.001) and the level of NT-proBNP decreased: from 3700 pg/ml (17455331) to 1366 pg/ml (10252878); p=0.007. A decrease in the marker was observed in 90% of patients. Hypotension (decrease in systolic blood pressure BP less than 90 mmHg) was observed in 10 (23.3%) patients. A statistically significant decrease in BP was found: systolic and diastolic BP on admission was 114 mmHg (100126) and 70 mmHg (7080), respectively, when CHF compensation was achieved 110 mmHg (98120) and 70 mmHg (6178); p=0.047 and p=0.013, respectively. The increase in hematocrit during hospitalization was also statistically significant from 43.53.6 to 46.14.9% (p0.001) and this was found in 67% of patients. A total of 4 (9.3%) patients had acute renal injury (decrease in estimated glomerular filtration rate GFR by 25% or more). At the same time, there was no decrease in GFR of less than 15 ml/min/1.73 m2. There was no statistically significant decrease in GFR and an increase in creatinine levels during hospitalization (p=0.214 and 0.173, respectively). Urinary tract infections were observed in 1 (2.3%) patient, transient hypoglycemia in 2 (4.7%) patients, which did not lead to the discontinuation of dapagliflozin. Diabetic ketoacidosis, allergic reactions, syncope, lower extremity amputations were not observed in patients taking dapagliflozin.
Conclusion. It can be concluded that dapagliflozin has a favorable safety profile when used in patients with ADHF, regardless of the presence or absence of diabetes.
Non-alcoholic fatty liver disease and cardiovascular risks: A review
Authors: Kotovskaya Yulia V.
Published: August 2023

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease. NAFLD may be associated with concomitant metabolic disorders (obesity, type 2 diabetes mellitus, dyslipidemia) and is often considered a hepatic manifestation of metabolic syndrome. In addition to hepatic morbidity and mortality, NAFLD is closely associated with asymptomatic and overt cardiovascular disease (CVD), leading to increased cardiovascular morbidity and mortality, and the more severe the hepatic disorder, the higher the risk. This review describes the main pathophysiological mechanisms linking NAFLD and CVD, discusses the role of NAFLD as a CVD risk factor, and addresses non-drug and drug therapies for NAFLD in the context of cardiovascular risk reduction. NAFLD makes patients candidates for more intensive therapeutic intervention to reduce hepatic and cardiovascular risks. Lifestyle modifications, including weight loss, increased physical activity, and nutritional adjustment, form the basis of NAFLD treatment. Correction of cardiovascular risk factors includes statins, antihypertensive agents, preferably renin-angiotensin system blockers. Ursodeoxycholic acid has therapeutic potential for beneficial effects on hepatic disorders and reducing cardiovascular risk.
Approach to the patient with adrenal incidentaloma. Case series
Authors: Ladygina Daria O. , Zorina Anastasia A. , Berkovskaya Marina A. , Chevais Anastassia , Beltsevich Dmitry G. , Fadeev Valentin V.
Published: August 2023

The formations of the adrenal glands are often detected accidentally during instrumental methods of examination of the abdominal cavity and retroperitoneal space, performed for some other reasons. Over the past 2 decades, the frequency of detection of adrenal gland formations has increased 10-fold, and most of them are diagnosed in old age. The tactics of observation and treatment depend both on hormonal activity and on the malignant potential of the detected formation. Up to 58% of patients with adrenal incidentalomas have a malignant nature, with a higher risk in young patients, with a size of more than 4 cm, as well as with a history of other malignant neoplasms. The frequency of detection of the classical clinical and laboratory picture of hypercorticism, hyperaldosteronism or catecholamine-producing tumor is less than 15%, however, the phenomenon of functionally autonomous cortisol production according to the results of studies conducted in the last few years is much more common up to 3050% of patients. Despite the absence of vivid clinical symptoms in some cases, autonomous cortisol secretion is associated with increased cardiovascular morbidity and metabolic disorders, therefore, all patients with adrenal incidentalomas need to exclude this condition. This article presents clinical cases of patients with adrenal gland formations, describes in detail the examination algorithm and the choice of treatment tactics, taking into account the results of studies conducted since the release of the latest clinical recommendations for the management of patients with adrenal gland incidentalomas in 2016.
ATP-independent substrate recruitment to proteasomal degradation in mycobacteria
Authors: von Rosen Tatjana , Pepelnjak Monika , Quast Jan-Philipp , Picotti Paola , Weber-Ban Eilika
Published: August 2023

Mycobacteria and other actinobacteria possess proteasomal degradation pathways in addition to the common bacterial compartmentalizing protease systems. Proteasomal degradation plays a crucial role in the survival of these bacteria in adverse environments. The mycobacterial proteasome interacts with several ring-shaped activators, including the bacterial proteasome activator (Bpa), which enables energy-independent degradation of heat shock repressor HspR. However, the mechanism of substrate selection and processing by the Bpa-proteasome complex remains unclear. In this study, we present evidence that disorder in substrates is required but not sufficient for recruitment to Bpa-mediated proteasomal degradation. We demonstrate that Bpa binds to the folded N-terminal helix-turn-helix domain of HspR, whereas the unstructured C-terminal tail of the substrate acts as a sequence-specific threading handle to promote efficient proteasomal degradation. In addition, we establish that the heat shock chaperone DnaK, which interacts with and co-regulates HspR, stabilizes HspR against Bpa-mediated proteasomal degradation. By phenotypical characterization ofMycobacterium smegmatisparent andbpadeletion mutant strains, we show that Bpa-dependent proteasomal degradation supports the survival of the bacterium under stress conditions by degrading HspR that regulates vital chaperones.
SF3B1mutation–mediated sensitization to H3B-8800 splicing inhibitor in chronic lymphocytic leukemia
Authors: López-Oreja Irene , Gohr André , Playa-Albinyana Heribert , Giró Ariadna , Arenas Fabian , Higashi Morihiro , Tripathi Rupal , López-Guerra Mònica , Irimia Manuel , Aymerich Marta , Valcárcel Juan , Bonnal Sophie , Colomer Dolors
Published: August 2023

Splicing factor 3B subunit 1 (SF3B1) is involved in pre-mRNA branch site recognition and is the target of antitumor-splicing inhibitors. Mutations inSF3B1are observed in 15% of patients with chronic lymphocytic leukemia (CLL) and are associated with poor prognosis, but their pathogenic mechanisms remain poorly understood. Using deep RNA-sequencing data from 298 CLL tumor samples and isogenicSF3B1WT and K700E-mutated CLL cell lines, we characterize targets and pre-mRNA sequence features associated with the selection of cryptic 3′ splice sites uponSF3B1mutation, including an event in theMAP3K7gene relevant for activation of NF-κB signaling. Using the H3B-8800 splicing modulator, we show, for the first time in CLL, cytotoxic effects in vitro in primary CLL samples and inSF3B1-mutated isogenic CLL cell lines, accompanied by major splicing changes and delayed leukemic infiltration in a CLL xenotransplant mouse model. H3B-8800 displayed preferential lethality towardsSF3B1-mutated cells and synergism with the BCL2 inhibitor venetoclax, supporting the potential use of SF3B1 inhibitors as a novel therapeutic strategy in CLL.
The Impact of Applying Lean Accounting Tools in Reducing Industrial Costs on a Sample of Companies Operating in Sudir Industrial -Kingdom Saudi Arabia
Authors: Abobaker Awadalla Gafer Elhussin
Published: August 2023

Purpose: This research intends to determine the effect of adopting lean accounting methods on a sample of enterprises operating in Sudair Industrial City in the Kingdom of Saudi Arabia in decreasing industrial expenses.
 
Theoretical framework:  In addition, it seeks to identify barriers to the use of lean accounting techniques. The researcher relied on a questionnaire that was pertinent to the topic of the study and its aims in order to meet the study's objectives, test the hypotheses, and answer the questions posed by the study sample.
 
Approach: A sample of thirty industrial businesses was picked at random. The descriptive analytical approach was used to characterize the research variables and test hypotheses by analyzing data using the statistical software SPSS. Eighty questionnaires were given.
 
Findings: The research yielded several findings, the most significant of which is the below-average adoption of the studied lean accounting methods owing to a lack of training and understanding of the lean accounting culture. Use accounting tools. The research also indicated that using lean accounting tools helps enterprises in Sudair Industrial City lower their industrial expenses, although there are hurdles to implementing lean accounting technologies.
 
Research, practical & social implications: The research ended with a series of suggestions, the most significant of which is the need for industrial enterprises to implement lean accounting principles, take use of the advantages and benefits afforded by this method, and disseminate the production culture and lean mindset.
 
Value: Creating efficient ways to overcome the constraints that limit the adoption of lean accounting technologies to realize the Saudi Arabian goal (2030).
Linking Ethical Leadership to Employee Creative Performace: The Role of Leader-Member Exchange and Work Engagement
Authors: Van Ha Khanh , Linh Pham Mai , Nhung Nguyen Thi Trang , Cuong Vu Manh
Published: August 2023

Purpose: The purpose of this research is to investigate the mediating role of leader-member exchange (LMX) and work engagement in the relationship between ethical leadership and creative performance.
 
Theoretical framework: The study is based on the theoretical foundation that ethical leadership positively influences creative performance. It further posits that this relationship is mediated by both leader-member exchange (LMX) and work engagement.
 
Design/Methodology/Approach: Data for this study was collected from a Vietnamese service firm, with a sample comprising 78 leaders and 354 employees. The collected data was analyzed using structural equation modeling (SEM) to examine the proposed relationships.
 
Findings: The findings of the study indicate a significant and positive correlation between ethical leadership and creative performance. Additionally, the study reveals that ethical leadership exerts an influence on both leader-member exchange (LMX) and work engagement, which subsequently enhance employees' demonstration of creativity in their work.
 
Research, practical & social implications: This research sheds light on the mediating mechanisms through which ethical leadership impacts creative performance. The findings highlight the importance of fostering positive leader-member relationships and promoting work engagement in order to enhance employees' creative behaviors. Practically, the study suggests that organizations should prioritize the development of ethical leadership qualities to foster a creative work environment. Moreover, the research contributes to the broader social implications by emphasizing the significance of ethical leadership in promoting creativity and innovation within organizations.
 
Originality/Value: This research contributes to the existing literature by examining the mediating role of leader-member exchange and work engagement in the relationship between ethical leadership and creative performance. The study provides valuable insights into the mechanisms through which ethical leaders can enhance creativity in the workplace. The findings of this research contribute to the understanding of the importance of ethical leadership and its impact on organizational outcomes, thereby adding to the originality and value of the study.
Pengendalian Suhu Air Nutrisi Pada Hidroponik NFT (Nutrient Film Technique) Berbasis Fuzzy Logic Controller
Authors: Asmbangnirwana Ikko , Endryansyah Endryansyah , Rusimamto Puput Wanarti , Zuhrie Muhammad Syariffuddien
Published: August 2023

Hidroponik ialah sebuah sistem pertanian dengan memanfaatkan air sebagai media tumbuh tanaman. Salah satu faktor penting dalam sistem hidroponik adalah air, karena air merupakan sumber hara bagi tanaman. Pada penelitian ini menggunakan kontroler logika Fuzzy untuk menstabilkan suhu air hidroponik yang bertujuan agar suhu air tetap terjaga pada tingkat suhu yang baik untuk tanaman. Suhu air yang baik untuk tanaman yaitu berkisar 25̊C sampai 28̊C, sehingga pada penelitian ini menggunakan setpoint 25̊C sampai 28̊C. Pada penelitian ini akan dilakukan dua percobaan yaitu yang pertama percobaan alat tanpa kontrol dan percobaan yang kedua menggunakan kontrol. Hasil dari kedua percobaan tersebut nantinya akan dianalisa kemudian akan dibandingkan. Berdasarkan hasil percobaan dengan kontrol dan tanpa kontrol diperoleh hasil bahwa suhu air lebih cepat turun atau stabil jika menggunakan kontrol. Sebab, ketika menggunakan kontroler maka peltier akan bekerja lebih optimal untuk menurunkan suhu air hidroponik. Dari percobaan ini grafik respon sistem perubahan suhu air hidroponik menurun mendekati setpoint, karena ketika setpoint tercapai maka alat akan otomatis berhenti bekerja.

Kata Kunci: Hidroponik, Suhu Air, Fuzzy Kontroler.
Pengaruh Jumlah Sudu Turbin Air Terhadap Kinerja Generator Pembangkit Listrik Tenaga Air
Authors: Dewangga Yudhistira Awang , Kholis Nur , Baskoro Farid , Haryudo Subuh Isnur
Published: August 2023

Tingkat kebutuhan akan sumber daya listrik pada saat ini sangat tinggi, kondisi geografis Indonesia memiliki banyak sungai dan air terjun dapat dimanfaatkan untuk menghasilkan listrik melalui pembangkit listrik tenaga air. Untuk meningkatkan kinerja pembangkit maka pemilihan penggunaan jenis turbin yang tepat serta komposisi jumlah sudu pada runner  generator yang sesuai dengan aliran debit air serta tinggi jatuh air membuat turbin dapat bekerja lebih efektif. Oleh karena itu, tujuan penulisan penelitian.ini adalah untuk menganalisis pengaruh jumlah sudu turbin  dan efisiensi sistem pada generator pembangkit listrik tenaga air. Variabel yang digunakan dalam penelitian adalah jenis sudu, debit aliran air, katup bukaan, geometris bilah sudu, diameter turbin serta sudut keluaran nozzle. Metode penelitian yang digunakan adalah literature review yang dilakukan dengan cara mengumpulkan referensi melalui jurnal dan referensi lainnya yang relevan dengan penelitian. Hasil penelitian yang didapatkan menujukkan bahwa jumlah sudu berbanding lurus dengan daya yang dihasilkan oleh generator listrik tenaga air, namun jumlah sudu tidak selalu mempengaruhi output dari generator, jumlah sudu yang sesuai dengan variabel yang dipergunakan secara optimallah yang mempengaruhi efisiensi sistem untuk mendapat daya yang optimal pada generator.

Kata Kunci: Pembangkit Listrik Tenaga Air, Jumlah Sudu.Turbin, Generator
Rancang Bangun Sistem Informasi Kehadiran Dosen dan Asisten Laboratorium Berbasis Internet of Things menggunakan RFID dan Aplikasi Telegram
Authors: Alamsyah Fiqih Yerdian , Baskoro Farid , Agustin T RR Hapsari Peni , Rakhmawati Lusia
Published: August 2023

Pandemi COVID-19 tentu sangat berdampak terhadap kebiasaan sosial masyarakat. Hal ini tentu saja juga berpengaruh pada kegiatan akademik di universitas. Dengan diterapkannya metode hybrid pada kegiatan akademik universitas maka timbul masalah bagi mahasiswa untuk mengetahui dosen sedang Work from Office (WFO) atau Work from Home (WFH). Rancang bangun sistem informasi berbasis Internet of Things (IOT) ini dibuat untuk memberikan solusi atas masalah tersebut. Sistem ini dibuat menggunakan mikrokontroler DOIT ESP32 DEVKIT V1 sebagai pusat pemrosesan data yang terhubung dengan modul sensor Radio Frequency Identification MFRC522 sebagai pengidentifikasi tag dan Bot API pada aplikasi Telegram yang digunakan sebagai interface pengguna. Dosen juga dapat mengubah kondisinya (sibuk/tidak sibuk) dengan cara mengirimkan pesan perintah kepada Bot API pada aplikasi Telegram. Dengan memanfaatkan Bot API pada aplikasi Telegram ini, mahasiswa dapat mengetahui informasi kehadiran dan keadaan dosen serta kehadiran asisten laboratorium di Laboratorium Telematika Universitas Negeri Surabaya (UNESA). Untuk mengetahui keandalan sistem yang dirancang, maka dilakukan beberapa pengujian terhadap sistem. Pengujian terhadap jarak baca maksimum RFID reader tanpa penghalang adalah 47mm, sementara RFID reader tidak dapat melakukan pembacaan apabila terhalang bidang konduktor, dan dengan penghalang isolator RFID reader dapat melakukan pembacaan namun jarak maksimal pembacaannya seiring berkurang seiring dengan bertambahnya ketebalan penghalang dengan bahan isolator. Berdasarkan hasil pengujian pengaruh Wi-Fi terhadap kecepatan identifikasi tag, didapatkan bahwa kecepatan identifikasi tag sangat dipengaruhi oleh kecepatan Wi-Fi yang digunakan dikarenakan sistem yang dirancang berbasis IOT sehingga sangat bergantung terhadap kecepatan internet yang digunakan.Kata Kunci: Kehadiran dosen, RFID, Telegram
The tumoral immunity state in purulent cholangitis
Authors: Maloshtan O. V. , Smachylo R. M. , Nekliudov A. O. , Kordon T. І. , Klyosova M. O. , Bychenko K. O. , Kozlov D. S.
Published: August 2023

Objective. Complex estimation of state of the immune system tumoral chain in patients, suffering purulent cholangitis was done to determine diagnostic and prognostic immunological markers in different course of the disease.

Materials and methods. Depending on pathological changes in biliary system of the investigated patients, they were distributed into three groups: I –cholangitis, caused by choledocholithiasis, ІІ – cholangitis in environment of cicatricial strictures, ІІІ – cholangitis in environment of performed reconstruction of ductal system. The levels of immunoglobulins A, M, G, and cytotoxical tumoral factors were investigated.

Results. In acute course of inflammation the changes in immunoreactivity were determined, showing high levels of immunoglobulins of early immune response. In chronic cholangitis the enhanced raising of the blood serum cytotoxicity was noted, and its level connection with the disease clinical severity. Statistically significant high level of the middle molecular mass polypeptides have constituted the result of accumulation of secondary endogenic toxins with their insufficient elimination.

Conclusion. The summarized amplitude in the immunoreactivity changes was maximally pronounced in patients with an acute course of cholangitis, demonstrating high levels of the early immune response immunoglobulins. In chronic course the signs of the immune response exhaustion dominated.
Odontología y nutrición
Authors: Suasnabas Pacheco Erika Jazmin , Lorenty Ruiz Luigy Wladimir , Montesdeoca Suárez Cesar Augusto , Zurita Blacio Solange Melina
Published: August 2023

La nutrición es un proceso biológico en el cual el ser vivo utiliza, transforma e incorpora a su cuerpo un aporte de nutrientes que recibe de los alimentos, para el funcionamiento, crecimiento y mantenimiento de sus funciones. Debido a la relación existente entre la dieta y la salud oral se hace necesario instruir a nuestros pacientes y a la población general, sobre la importancia de unos hábitos alimentarios adecuados, facilitando para ello asesoramiento desde el punto de vista nutricional y de la salud dental. La etiología de la caries es multifactorial, existen tres factores esenciales a los que se añade el tiempo: huésped, microorganismos y dieta. La presencia o ausencia de servicios sanitarios y programas de salud oral, nivel socio económico, estrés, etnia, cultura, factores de ingeniería bio-dental (biomecánicos, bioquímicos y bio-eléctricos). Existe un probiótico para uso odontológico, es un producto para la higiene bucal que combate la placa, la gingivitis y las bacterias cariogénicas mediante la combinación patentada de dos cepas de Lactobacillus reuteri, reside en el tracto gastrointestinal en humanos y produce una sustancia antibiótica de amplio espectro denominada "reuterina", que en suficiente cantidad causa el efecto antimicrobiano para mantener la microbiota intestinal intacta. Debido a la relación existente entre la dieta y la salud oral se hace necesario instruir a nuestros pacientes y a la población general, sobre la importancia de unos hábitos alimentarios adecuados, facilitando para ello asesoramiento desde el punto de vista nutricional y de la salud dental. Es frecuente la pérdida de dientes en el adulto mayor lo que puede ser atribuido a la presencia de enfermedades crónicas, uso de múltiples medicamentos y deficiente cuidado bucal. El estado de la dentición interfiere con la elección y consumo de alimentos, es causa de problemas de nutrición, en particular cuando no son sustituidos por prótesis o éstas se encuentran en mal estado.Se aplicó una metodología descriptiva, con un enfoque documental, es decir, revisar fuentes disponibles en la red, con contenido oportuno y relevante para dar respuesta a lo tratado en el presente artículo.
De la exclusión a la inclusión. La evolución de las Constituciones de la República Ecuador
Authors: Galeas Guamán Mirian Violeta , Palate Mera Mónica Alexandra , Aguirre Aguirre Elsa del Rosario , Oña Vega Mirtha Neraida
Published: August 2023

El presente estudio tuvo como objetivo describir y reflexionar acerca de las tres constituciones de la República del Ecuador, la de 1830 caracterizada por la exclusión y la de 1998 y 2008 por su enfoque en la protección de los derechos humanos ciudadanos, en las cuales se hace evidente el contexto, las políticas y teorías filosóficas que influyen en los gobiernos que las generan, dando como consecuencia la organización estructural y social del Estado y ciudadanía ecuatoriana. Las constituciones marcan ideologías políticas de privilegios, alianzas, exclusión, explotación, desconocimiento de los derechos ciudadanos como es el caso de la Constitución de 1830 con cual un gran sector de la población fue afectado. La Constitución de 1998 dictamina, como propiedad del Estado, las riquezas naturales no renovables, inalienables e imprescriptibles, vigilancia del seguro social, libertad absoluta del Banco Central en sus funciones económicas, crediticia y cambiara, mayor control en los gastos públicos, en el ámbito social ofrece educación como derecho de las personas y un deber inevitable e inexcusable del Estado, responde a la igualdad e inclusión social, una condición indispensable para El Buen Vivir. La Constitución del 2008, con neo ideologías políticas y sociales se hicieron evidentes para gobernar legalmente al país, un acuerdo de reglas de relación, una representación de alianza político y social, forjando participación, inclusión social, promoción de derechos y respeto a la sabiduría ancestral para fomentar el Buen Vivir o Sumak Kaway.
Assessment of plasma protein C activity in dogs with portosystemic shunt
Authors: Nečasová Andrea , Lorenzová Jana , Řeháková Kristína , Haruštiaková Danka , Nečas Alois
Published: August 2023

Portosystemic shunt (PSS) is a vascular disease that can be treated by various surgical techniques. Current veterinary studies are evaluating new prognostic markers in dogs with PSS. This study aims at evaluating the prognostic value of plasma protein C activity in dogs (n = 34) with PSS treated surgically using an ameroid constrictor. Plasma protein C activity was measured in the following time periods: preoperatively (T1), 2 days after surgery (T2), 8 weeks after surgery (T3) and > 6 months after surgery (T4). There was a significant increase in plasma protein C activity between T1/T2 and T3/T4 (P < 0.001). There was no significant relationship between the plasma protein C activity and sex (P = 0.676), age (P = 0.172), breed (P = 0.573), type of clinical signs (neurological P = 0.993; gastrointestinal P = 0.924; urological P = 0.385) and type of portosystemic shunt (P = 0.516), except for dogs with a caval type of extrahepatic PSS termination that had significant lower plasma protein C activity values compared to dogs with a diaphragmatic type of extrahepatic PSS (P = 0.031). No significant relationship was found between plasma protein C activity and the probability of the dog’s death (P = 0.334) or the dog’s clinical outcome (P = 0.960). Although not a prognostic factor, protein C activity is a laboratory marker that is useful for the diagnosis of PSS in dogs and can also be helpful in the postoperative monitoring.
СОВРЕМЕННЫЕ ИНФОРМАЦИОННЫЕ ТЕХНОЛОГИИ В ФИЗИЧЕСКОМ ВОСПИТАНИИ И СПОРТЕ
Authors: A.A. Ramazanov  , A.S. Huseynov
Published: August 2023

Использование информационных технологий является настоятельной необходимостью в системе подготовки и переподготовки современного спортсмена. Высокие спортивные достижения представителей развитых стран на международных соревнованих самого высокого ранга обусловлены эффективным использованием данных технологий в повышении их спортивного мастерства. Если мы хотим, чтобы азербайджанский спорт на равных конкурировал с лучшими зарубежными представителями, необходимо приложить серьёзныеусилия для внедрения современных информационных технологий в подготовке высококлассных спортсменов.
FİZİKİ YÜKDƏN ƏVVƏL VƏ SONRA TƏLƏBƏ-İDMANÇILARDA ÜRƏKDAMAR SİSTEMİNİN FUNKSİONAL VƏZİYYƏTİNİN TƏDQİQİ
Authors: R.M. Baghirova  , L.I. Safarli  , M.A. Gulieva
Published: August 2023

Tədqiqat işinin əsas məqsədi əzələ yükünə uyğunlaşmanın müxtəlif dərəcələrində olan idmançılarda ürək-damar sisteminin funksional xüsusiyyətlərinin səviyyəsini və spesifik xüsusiyyətlərini öyrənmək idi. Aparılan tədqiqatlar göstərdi ki, ürək-damar sistemi fizioloji cəhətdən ən əhəmiyyətli sistemlərdən biri olmaqla orqanizmin müxtəlif idman effektlərinə uyğunlaşmasını təmin edir və orqanizmin bərpa proseslərinin dinamikasını əks etdirir. Ürək-damar sistemi orqanizmin fizioloji vəziyyətinin ən həssas göstəricisidir və onun öyrənilməsi ilə tədqiqatlar başlayır - idmanın insan sağlamlığına təsiri.

Nəticədə, idmançılarda ürək-damar sisteminin fiziki yüklərə effektiv uyğunlaşmasının formalaşdırılmasının orqanizmdə uzunmüddətli uyğunlaşma proseslərini stimullaşdıran fizioloji cəhətdən əsaslandırılmış vasitə və üsulların uğurlu olacağına dair fərziyyəni sübut etdik.
FİZİKİ TƏRBİYƏ VASİTƏLƏRİNİN KÖMƏYİ İLƏ DAYAQ-HƏRƏKƏT APARATINDA POZULMALARIN BƏRPASI
Authors: G.R. Mammadova  , R.M.Baghirova  , S.A. Jafarova
Published: August 2023

Məqalədə dayaq - hərəkət aparatının ayrı-ayrı şöbələrində pozulmaları olan şəxslərin fiziki tərbiyə vasitələrinin köməyi ilə bərpa olunmasının bəzi məsələləri əksini tapmışdır. Dayaq-hərəkət aparatında yaranan zədələnmələrin yaratdığı problemlər və onların həlli yolları da araşdırılmışdır. Dayaq-hərəkət aparatında zədələnmələrinin və pozulmalarının bərpasının ən universal və əlçatan vasitəsi fiziki tərbiyə hərəkətləri hesab olunduğundan, yaranan zədələnmələrin növlərinin dərəcəsinin və fərdi xüsusiyyətllərinin xarakterindən asılı olaraq baş verən dəyişiliklərin müəyyənləşdirilməsi və qeydiyyatı da aparılmşdır. Topla icra olunan müxtəlif hərəktlərdən istifadə bütün fiziki keyfiyyətlərin inkişafına müsbət təsir göstərir. Ona görə də topla oyun hərəkətlərin icra olunmasına dair tövsiyyələr də verilmişdir. Belə hallarda nəzərdə tutulur ki, yüksək emosionallıq və oyunlara həvəs/aludəçilk hərəki tapşırıqların icrasına effektiv təsirə malikdir.
GÜLƏŞÇİNİN QÜVVƏ HAZIRLIĞININ TƏKMİLLƏŞDİRİLMƏSİ
Authors: Y.S. Jalalov
Published: August 2023

Qüvvə güləşçinin əsas hərəki keyfiyyətlərindən biridir. O yalnız əzələ fəaliyyəti zamanı inkişaf edir və təkmilləşir. Güləşmə məşğələlərində tətbiq edilən fiziki qüvvə hərəkətləri həcminə, istiqamətinə və xarakterinə görə fasiləsiz olaraq dəyişilir. Bu zəruriyyət yarış mübarizəsi zamanı yaranan vəziyyətlərlə əlaqədar olaraq irəli gəlir. Son dövrlərdə güləş növləri üzrə yarış qaydalarında da ciddi dəyişikliklər edilir. Bu qaydalara uyğunlaşmaq güləşçilərdən böyük qüvvə və onun təkmilləşməsini tələb edir. Məhz buna görə güləşmə məşğələlərində qüvvə hazırlığı zamanı məşqçilər yeni-yeni təmrinlər tətbiq etməli olurlar.
QEYRİ-XƏTTİ REQRESİYA MODELİ VASİTƏSİLƏ SÜRƏT KEYFİYƏTLƏRİNƏ NƏZARƏTİN YERİNƏ YETİRİLMƏSİ
Authors: N.M. Kalantarli  , T.G. Abiyev
Published: August 2023

Məqalə qeyri-xətti reqresiya modeli vasitəsilə idmançıların sürət keyfiyyətlərinə nəzarətin yerinə yetirilməsinə həsr edilib. Aparılan tədqiqatlar əsasnda idmançıların fizioloji və biomexaniki göstəriciləri arasındakı asılılığın ikinci tərtib parabola tənliyi ilə ifad olunduğu aşkar edilmişdir. Müasir texniki vsitələrin köməyi ilə qeydə alınmış empirik göstəricilər əsasında müxtəlif səviyyəli idmançılar üçün reqresiya tənlikləri qurulmuşdur. Bu tənliklər fizioloji və biomexaniki göstəriciləri proqnozlaşdırmaqla – məşqçiyə idmançının güclü tərəflərini təkminləşdirmək, zəif tərəflərini inkişaf etdirmək məqsədilə müvafiq test tapşırıqlarını təşkil etmək imkanı yaradır.
Carnaval de Escada, Pernambuco, Brasil:
Authors: Silva Tarcisio Augusto Alves da , Da Silva Kaline Maria , Conserva Rayanne Carolyne Lira
Published: August 2023

O presente artigo traz dados de uma pesquisa sobre registros em jornais e memórias de brincantes a respeito do Carnaval da cidade de Escada, Pernambuco (BR). O objetivo é apresentar uma sistematização desses registros e memórias de modo a compreender os processos de mudanças pelas quais o Carnaval do município vem passando. Procuramos, também, apresentar os principais blocos carnavalescos da cidade e fatos marcantes de sua história. A investigação se fundamentou em dados primários (entrevistas) e secundários (fotos, documentos de fundação, jornais, atas e sites de notícias) relativos ao Carnaval do município. Os resultados mostram as transformações vividas, o desaparecimento e o surgimento de novas agremiações e acontecimentos que marcaram o Carnaval da cidade.
Cidades Negras no Brasil:
Authors: Oliveira Reinaldo José de
Published: August 2023

A interpretação das cidades negras tem como objetivo conhecer melhor a realidade dos espaços negros, da segregação racial e do território. Avaliamos que a ideia de segregação racial está baseada em categorias de classe social, gênero, etnia e raça e território, porém, a realidade das Américas, especialmente brasileira, deve ser observada, sobretudo o tempo-espaço da colonização, do escravismo e do racismo. Utilizamos como instrumento teórico-metodológico, primeiro, os dados estatísticos do Censo do IBGE de 2010 sobre a população classificada por negros e brancos, e o rendimento. Segundo, para melhor delineamento, dialogamos com autores de ambos os campos das relações étnico-raciais e a literatura sobre a cidade, o urbano e o território. Em nossas considerações será um grande desafio para as Américas, o Brasil e a Bahia, a promoção de políticas públicas para a inscrição de cidades antirracistas e democráticas com equidade.
Black Cities in Brazil:
Authors: José de Oliveira Reinaldo
Published: August 2023

The interpretation of black cities aims to better understand the reality of black spaces, racial segregation and territory. We assess that the idea of racial segregation is based on categories of social class, gender, ethnicity and race and territory, however, the reality of the Americas, especially Brazilian, must be observed, especially the time-space of colonization, slavery and racism. We used as a theoretical-methodological instrument, first, the statistical data of the IBGE Census of 2010, on the population classified by blacks and whites, and income. Second, for a better design, we dialogue with authors from both fields of ethnic-racial relations and the literature on the city, the urban and the territory. In our considerations, it will be a great challenge for the Americas, Brazil and Bahia, the promotion of public policies for the inscription of anti-racist and democratic cities with equity.
Editorial
Authors: das Neves Bodart Cristiano
Published: August 2023

.O dossiê Cidades negras nas Américas: a produção de políticas de enfrentamento ao racismo, tem como objetivo compor reflexões, estudos e pesquisas que versem sobre o espaço urbano, relações étnico raciais, segregação, racismo e políticas públicas nas cidades dos territórios latino americano e norte-americano. A questão do direito à cidade, inicialmente, protagonizada por Henri Lefebvre, em nossa atualidade, deve ser observada por múltiplos quadros das desigualdades, em especial, o direito à igualdade étnico racial e às diferenças culturais das populações negras. É imprescindível contextualizar cidades, relações étnico raciais, segregação e políticas públicas em sociedades fundadas com históricos do escravismo, colonialismo, patriarcalismo e do capitalismo dos séculos XX e XXI.
PROBLEMS OF METHODOLOGY FOR FORENSIC STUDY OF POISONOUS SUBSTANCES
Authors: Kuzovlev Vladislav , Kharchenko Irina , Geraskin Mikhail
Published: August 2023

The article is devoted to the problems of the methodology of one of the relatively rare subspecies of the examination of materials, substances and products - the study of toxic substances. The authors considered various physical and chemical methods of forensic examination of toxic substances and recommended the most optimal ones, depending on the nature of the substance. An algorithm for the expert study of toxic substances is also proposed, including using the automated information retrieval system “AIPSIN-Antinarcotics”.
DIGITAL TRANSFORMATION OF REGIONAL SUB-COMPLEXES OF AIC
Authors: Truba Anatoliy , Karataeva Oksana
Published: August 2023

The article defines the relevance, purpose and objectives of the study of the theoretical aspects of digitalization and digital transformation of society. The analysis of international indices of digital transformation digital approaches in assessing the level of development of the digital economy of countries in a typical rating was carried out. The importance of using a platform approach at the regional level of the agro-industrial complex to create a digital entrepreneurial rural ecosystem is determined.
FEATURES OF FOREIGN EXPERIENCE IN CONSTRUCTION AND FUNCTIONING OF A MULTI-FACTORY SYSTEM OF MOTIVATION OF PUBLIC EMPLOYEES
Authors: Petrova Yuliya
Published: August 2023

The article discusses some aspects of labor motivation that have become an effective regulator of civil servants on the example of Finland and the People's Republic of China, where the principles of professional responsibility, respect for the rights of citizens and public openness serve as the basis.
COUNTER-URBANIZATION AS A FACTOR OF HUMAN CAPITAL DEVELOPMENT
Authors: Koval Sergey , Koval' Anna
Published: August 2023

Agriculture is one of the key sectors of the economy of the Siberian Federal District. Agriculture is re-sponsible not only for ensuring the food security of the region, but also is the most important export direc-tion. However, for the development of this industry, it is necessary to ensure a high level of human capi-tal. Human capital is still the main resource of the industry, it is it that allows us to ensure high labor productivity, solve problems to improve production efficiency. Ensuring the quality of human capital formation remains important. If we consider the example of the agricultural sector, then there is a problem of the formation of human capital. Most agricultural producers, due to the specifics of production, are forced to be located in the regions of large cities. Such an arrangement of organizations is a negative fac-tor for the qualitative formation of human capital. In the article, the influence of technological structures on the development of the agricultural sector and the impact of the transition from industrial to post-industrial society on the countryside are considered, as well as mechanisms for counter-urbanization are proposed.