bluuebunny/crossref_metadata_2025 huggingface dataset:
On the Theoretical Link between Optimized Geospatial Conflation Models for Linear Features
Authors: Lei Zhen , Yuan Zhangshun , Lei Ting L.
Published: August 2024

Geospatial data conflation involves matching and combining two maps to create a new map. It has received increased research attention in recent years due to its wide range of applications in GIS (Geographic Information System) data production and analysis. The map assignment problem (conceptualized in the 1980s) is one of the earliest conflation methods, in which GIS features from two maps are matched by minimizing their total discrepancy or distance. Recently, more flexible optimization models have been proposed. This includes conflation models based on the network flow problem and new models based on Mixed Integer Linear Programming (MILP). A natural question is: how are these models related or different, and how do they compare? In this study, an analytic review of major optimized conflation models in the literature is conducted and the structural linkages between them are identified. Moreover, a MILP model (the base-matching problem) and its bi-matching version are presented as a common basis. Our analysis shows that the assignment problem and all other optimized conflation models in the literature can be viewed or reformulated as variants of the base models. For network-flow based models, proof is presented that the base-matching problem is equivalent to the network-flow based fixed-charge-matching model. The equivalence of the MILP reformulation is also verified experimentally. For the existing MILP-based models, common notation is established and used to demonstrate that they are extensions of the base models in straight-forward ways. The contributions of this study are threefold. Firstly, it helps the analyst to understand the structural commonalities and differences of current conflation models and to choose different models. Secondly, by reformulating the network-flow models (and therefore, all current models) using MILP, the presented work eases the practical application of conflation by leveraging the many off-the-shelf MILP solvers. Thirdly, the base models can serve as a common ground for studying and writing new conflation models by allowing a modular and incremental way of model development.
Integrating Sequential Backward Selection (SBS) and CatBoost for Snow Avalanche Susceptibility Mapping at Catchment Scale
Authors: Cetinkaya Sinem , Kocaman Sultan
Published: August 2024

Snow avalanche susceptibility (AS) mapping is a crucial step in predicting and mitigating avalanche risks in mountainous regions. The conditioning factors used in AS modeling are diverse, and the optimal set of factors depends on the environmental and geological characteristics of the region. Using a sub-optimal set of input features with a data-driven machine learning (ML) method can lead to challenges like dealing with high-dimensional data, overfitting, and reduced model generalization. This study implemented a robust framework involving the Sequential Backward Selection (SBS) algorithm and a decision-tree based ML model, CatBoost, for the automatic selection of predictive variables for AS mapping. A comprehensive inventory of a large avalanche period, previously derived from satellite images, was used for the investigations in three distinct catchment areas in the Swiss Alps. The integrated SBS-CatBoost approach achieved very high classification accuracies between 94% and 97% for the three catchments. In addition, the Shapley additive explanations (SHAP) method was employed to analyze the contributions of each feature to avalanche occurrences. The proposed methodology revealed the benefits of integrating advanced feature selection algorithms with ML techniques for AS assessment. We aimed to contribute to avalanche hazard knowledge by assessing the impact of each feature in model learning.
Macrophages and Gut Barrier Function: Guardians of Gastrointestinal Health in Post-Inflammatory and Post-Infection Responses
Authors: Meng Edward Xiangtai , Verne George Nicholas , Zhou Qiqi
Published: August 2024

The gut barrier is essential for protection against pathogens and maintaining homeostasis. Macrophages are key players in the immune system, are indispensable for intestinal health, and contribute to immune defense and repair mechanisms. Understanding the multifaceted roles of macrophages can provide critical insights into maintaining and restoring gastrointestinal (GI) health. This review explores the essential role of macrophages in maintaining the gut barrier function and their contribution to post-inflammatory and post-infectious responses in the gut. Macrophages significantly contribute to gut barrier integrity through epithelial repair, immune modulation, and interactions with gut microbiota. They demonstrate active plasticity by switching phenotypes to resolve inflammation, facilitate tissue repair, and regulate microbial populations following an infection or inflammation. In addition, tissue-resident (M2) and infiltration (M1) macrophages convert to each other in gut problems such as IBS and IBD via major signaling pathways mediated by NF-κB, JAK/STAT, PI3K/AKT, MAPK, Toll-like receptors, and specific microRNAs such as miR-155, miR-29, miR-146a, and miR-199, which may be good targets for new therapeutic approaches. Future research should focus on elucidating the detailed molecular mechanisms and developing personalized therapeutic approaches to fully harness the potential of macrophages to maintain and restore intestinal permeability and gut health.
Applying Molecular Modeling to the Design of Innovative, Non-Symmetrical CXCR4 Inhibitors with Potent Anticancer Activity
Authors: Martínez-Asensio Miquel , Sàrrias Lluís , Gorjón-de-Pablo Gema , Fernández-Serrano Miranda , Camaló-Vila Judith , Gibert Albert , Puig de la Bellacasa Raimon , Teixidó Jordi , Roué Gaël , Borrell José I. , Estrada-Tejedor Roger
Published: August 2024

The identification of new compounds with potential activity against CXC chemokine receptor type 4 (CXCR4) has been broadly studied, implying several chemical families, particularly AMD3100 derivatives. Molecular modeling has played a pivotal role in the identification of new active compounds. But, has its golden age ended? A virtual library of 450,000 tetraamines of general structure 8 was constructed by using five spacers and 300 diamines, which were obtained from the corresponding commercially available cyclic amines. Diversity selection was performed to guide the virtual screening of the former database and to select the most representative set of compounds. Molecular docking on the CXCR4 crystal structure allowed us to rank the selection and identify those candidate molecules with potential antitumor activity against diffuse large B-cell lymphoma (DLBCL). Among them, compound A{17,18} stood out for being a non-symmetrical structure, synthetically feasible, and with promising activity against DLBCL in in vitro experiments. The focused study of symmetrical-related compounds allowed us to identify potential pre-hits (IC50~20 µM), evidencing that molecular design is still relevant in the development of new CXCR4 inhibitor candidates.
Post-Hoc Analysis of Potential Correlates of Protection of a Recombinant SARS-CoV-2 Spike Protein Extracellular Domain Vaccine Formulated with Advax-CpG55.2-Adjuvant
Authors: Petrovsky Nikolai
Published: August 2024

SpikoGen® vaccine is a subunit COVID-19 vaccine composed of an insect cell expressed recombinant spike protein extracellular domain formulated with Advax-CpG55.2™ adjuvant. A randomized double-blind, placebo-controlled Phase II clinical trial was conducted in 400 adult subjects who were randomized 3:1 to receive two intramuscular doses three weeks apart of either SpikoGen® vaccine 25 μg or saline placebo, as previously reported. This study reports a post hoc analysis of the trial data to explore potential immune correlates of SpikoGen® vaccine protection. A range of humoral markers collected pre- and post-vaccination, including spike- and RBD-binding IgG and IgA, surrogate (sVNT), and conventional (cVNT) virus neutralization tests were compared between participants who remained infection-free or got infected over three months of follow-up. From 2 weeks after the second vaccine dose, 21 participants were diagnosed with SARS-CoV-2 infection, 13 (4.2%) in the SpikoGen® group and 8 (9%) in the placebo group. Those in the vaccinated group who experienced breakthrough infections had significantly lower sVNT titers (GMT 5.75 μg/mL, 95% CI; 3.72–8.91) two weeks after the second dose (day 35) than those who did not get infected (GMT 21.06 μg/mL, 95% CI; 16.57–26.76). Conversely, those who did not develop SARS-CoV-2 infection during follow-up had significantly higher baseline sVNT, cVNT, spike-binding IgG and IgA, and RBD-binding IgG, consistent with a past SARS-CoV-2 infection. SpikoGen® further reduced the risk of re-infection (OR 0.29) in baseline seropositive (previously infected) as well as baseline seronegative participants. This indicates that while SpikoGen vaccine is protective in seronegative individuals, those with hybrid immunity have the most robust protection.
Ruthenium-Based Sensors
Authors: Therrien Bruno
Published: August 2024

In the periodic table of the elements, ruthenium occupies an excellent position, just below iron. And like iron, it possesses several oxidation states, with +2 and +3 being the most common. Accordingly, ruthenium chemistry is extremely rich and well developed, and ruthenium complexes show excellent catalytic aptitude, tremendous redox capacity, and intriguing biological activity. However, in the design of sensors, the use of ruthenium complexes can be better exploited, as they possess valuable electro- and photochemical properties. Therefore, there is an opportunity here, and ruthenium-based complexes might become, one day, key players in sensing technology. Starting a new research project with ruthenium-based sensors ourselves, writing this review was essential to see the current state of research in the field, to better identify opportunities and to have an overview of state-of-the-art examples.
New Records of Sharpshooters (Hemiptera, Cicadellidae, Cicadellinae) in Citrus Orchards in Amazonas State, Brazil
Authors: Moreno Franco Paola Victoria , Froza Joyce Adriana , Pecly Nathalia Hiluy , Lopes João Roberto Spotti , Lima Jânia Lilia da Silva Bentes , Acioli Agno Nonato Serrão
Published: August 2024

This research study reports new records of eight species of Cicadellini (Hemiptera, Cicadellidae, Cicadellinae) across seven municipalities in Amazonas State, Brazil. Among these species, one is known as a vector of CVC (Provancherana corniculata). Additionally, five species are being reported for the first time in citrus for the State (Erythrogonia sexguttata, Hortensia similis, Provancherana corniculata, Scopogonalia amazonensis, and Scoposcartula oculata), and three species (Diedrocephala variegata, Macugonalia moesta and Xyphon reticulatum) are reported for the first time in the northern region. This research highlights the lack of information on sharpshooter occurrence in the Amazonas region, emphasizing the need for further investigations in this area.
MALDI-TOF MS Profiling and Its Contribution to Mosquito-Borne Diseases: A Systematic Review
Authors: Costa Monique Melo , Corbel Vincent , Ben Hamouda Refka , Almeras Lionel
Published: August 2024

Mosquito-borne diseases are responsible for hundreds of thousands of deaths per year. The identification and control of the vectors that transmit pathogens to humans are crucial for disease prevention and management. Currently, morphological classification and molecular analyses via DNA barcoding are the standard methods used for vector identification. However, these approaches have several limitations. In the last decade, matrix-assisted laser desorption/ionization–time-of-flight mass spectrometry (MALDI-TOF MS) profiling has emerged as an innovative technology in biological sciences and is now considered as a relevant tool for the identification of pathogens and arthropods. Beyond species identification, this tool is also valuable for determining various life traits of arthropod vectors. The purpose of the present systematic review was to highlight the contribution of MALDI-TOF MS to the surveillance and control of mosquito-borne diseases. Published articles from January 2003 to August 2024 were retrieved, focusing on different aspects of mosquito life traits that could be determinants in disease transmission and vector management. The screening of the scientific literature resulted in the selection of 54 published articles that assessed MALDI-TOF MS profiling to study various mosquito biological factors, such species identification, life expectancy, gender, trophic preferences, microbiota, and insecticide resistance. Although a large majority of the selected articles focused on species identification, the present review shows that MALDI-TOF MS profiling is promising for rapidly identifying various mosquito life traits, with high-throughput capacity, reliability, and low cost. The strengths and weaknesses of this proteomic tool for vector control and surveillance are discussed.
Optimal Positioning of Load-Distributing Band CPR Device by Body Mass Index
Authors: Kim Dong-gyu , Park Eunhyang , Choi Dongsun
Published: August 2024

Background: Research investigating the optimal compression position for load-distributing bands (LDBs) in treating cardiac arrest is limited This study aimed to determine the optimal LDB position based on body mass index (BMI). Methods: A simulation study was conducted using chest and abdominal computed tomography imaging data collected with patients in the arms-down position. Participants were categorized into three BMI groups: low (<18.5 kg/m2), normal (18.5–25 kg/m2), and high (≥25 kg/m2). The assumed compression area was 20 cm below the axilla. The optimal compression position was identified by adjusting the axilla to maximize the thorax-to-abdomen volume ratio (TAR) and the covered heart volume ratio (CHR), defined as the ratio of heart volume compressed by the LDB to total heart volume. Optimal compression positions were compared across BMI groups. Results: Among 117 patients, TAR was significantly lower in the low BMI group compared to the normal and high BMI groups (p < 0.001), while CHR differences were not significant (p = 0.011). The distance between the optimal position and axilla height was significantly greater in the normal and high BMI groups than in the low BMI group (46.5 cm vs. 66.0 cm vs. 72 cm, respectively; p < 0.001). For each unit increase in BMI, the optimal position shifted significantly cephalad relative to axilla height (β coefficient 2.39, adjusted p < 0.001). Conclusions: Significant differences in TAR were observed among BMI groups. As BMI increased, the optimal LDB position shifted progressively cephalad.
Hand Digit Revascularization: Could Be an “Elective-Urgence” Surgery?
Authors: De Francesco Francesco , Mani Olimpia , Gravina Pasquale , Riccio Michele
Published: August 2024

Background: A continuous obstacle that has limited access to and implementation of finger replantation surgery is timeliness, as ischemia time is traditionally considered a crucial factor for success. However, claims that the vitality of amputated fingers decreases after 6 h of warm ischemia and 12 h of cold ischemia are mostly based on theoretical considerations. Methods: Here we present a case of multi-digit revascularization after 72 h of warm ischemia using the microsurgical arteriovenous bypass technique. Results: In the reported case, revascularization was performed after a long ischemic period and showed good recovery of motor and sensory function. Conclusions: We identified significant limitations in the literature supporting time limits of ischemia and recent evidence demonstrating the feasibility of delayed finger replantation. The current treatment approach for amputation injuries often requires transfers or nighttime emergency procedures, increasing costs and limiting the national availability of finger replantation. Changes to finger replantation protocols based on evidence could expand access to this service and improve the quality of care.
Epidemiological Changes in Transthyretin Cardiac Amyloidosis: Evidence from In Vivo Data and Autoptic Series
Authors: Cianci Vincenzo , Cianci Alessio , Sapienza Daniela , Cracò Annalisa , Germanà Antonino , Ieni Antonio , Gualniera Patrizia , Asmundo Alessio , Mondello Cristina
Published: August 2024

Cardiac amyloidosis is an infiltrative disease that causes progressive myocardial impairment secondary to amyloid fibril deposition in the extracellular space of the myocardium. Many amyloid precursors, including transthyretin protein, are known to determine cardiac damage by aggregating and precipitating in cardiac tissue. Transthyretin cardiac amyloidosis may be either caused by rare genetic mutations of the transthyretin gene in the hereditary variant, or may arise as a consequence of age-related mechanisms in the acquired form. Although it has been labeled as a rare disease, in recent years, transthyretin cardiac amyloidosis has stood out as an emerging cause of aortic stenosis, unexplained left ventricular hypertrophy and heart failure with preserved ejection fraction, particularly in the elderly. Indeed, the integration of data deriving from both in vivo imaging techniques (whose advancement in the last years has allowed to achieve an easier and more accessible non-invasive diagnosis) and forensic studies (showing a prevalence of amyloid deposition in cardiac tissue of elderly patients up to 29%) suggests that cardiac amyloidosis is a more common disease than traditionally considered. Thanks to all the improvements in non-invasive diagnostic techniques, along with the development of efficacious therapies offering improvements in survival rates, transthyretin cardiac amyloidosis has been transformed from an incurable and infrequent condition to a relatively more diffuse and treatable disease, which physicians should take into consideration in the differential diagnostic processes in daily clinical practice.
Impact of Pore Structure on Seepage Capacity in Tight Reservoir Intervals in Shahejie Formation, Bohai Bay Basin
Authors: Zhu Shaogong , Cao Yudong , Huang Qiangtai , Yu Haotong , Chen Weiyan , Zhong Yujie , Chen Wenchao
Published: August 2024

The exploration and development of conventional oil and gas resources are becoming more difficult, and the proportion of low-permeability reservoirs in newly discovered reservoir resources has expanded to 45%. As the main focus of the oil industry, the global average recovery rate of low-permeability reservoir resources is only 20%, and most crude oil is still unavailable, so our understanding of such reservoirs needs to be deepened. The microscopic pore structure of low-permeability reservoir rocks exhibits significant complexity and variability; reservoir evaluation is more difficult. For elucidating the internal distribution of storage space and the mechanisms influencing seepage, we focus on the low-permeability sandstone reservoir of the Shahejie Formation, located on the northern slope of the Chenjiazhuang uplift, Bohai Bay. Employing a suite of advanced analytical techniques, including helium expansion, pressure pulse, high-pressure mercury intrusion (HPMI), and micro-computed tomography (micro-CT) scanning, we examined the main pore–throat size affecting reservoir storage and seepage in the reservoir at both the micrometer and nanometer scales. The results reveal that pores with diameters exceeding 40 μm are sparsely developed within the low-permeability reservoir rocks of the study area. However, pores ranging from 0 to 20 μm predominate, exhibiting an uneven distribution and a clustered structure in the three-dimensional pore structure model. The pore volume showed a unimodal and bimodal distribution, thus significantly contributing to the storage space. The main sizes of the reservoir in this study area are 40–80 μm and 200–400 μm. Micron-sized pores, while present, are not the primary determinants of the reservoir’s seepage capacity. Instead, coarser submicron and nano-pores exert a more substantial influence on the permeability of the rock. Additionally, the presence of micro-fractures is found to enhance the reservoir’s seepage capacity markedly. The critical pore–throat size range impacting the permeability of the reservoir in the study area is identified to be between 0.025 and 0.4 μm.
Mindfulness vs. Physiotherapy vs. Medical Therapy: Uncovering the Best Postoperative Recovery Method for Low Back Surgery Patients during the COVID-19 Pandemic—A Single Institution’s Experience
Authors: La Rocca Giuseppe , Orlando Vittorio , Galieri Gianluca , Mazzucchi Edoardo , Pignotti Fabrizio , Cusumano Davide , Bazzu Paola , Olivi Alessandro , Sabatino Giovanni
Published: August 2024

Introduction: This study aimed to evaluate the efficacy of mindfulness therapy compared to traditional physiotherapy and usual care in alleviating postoperative pain and improving functional outcomes in patients undergoing lumbar spine surgery during the COVID-19 pandemic. Methods: Ninety patients undergoing lumbar decompression and fusion (LDF) who presented persistent low back pain after surgery were prospectively followed for one year. They were randomly divided into three groups: mindfulness therapy, physiotherapy, and medical therapy. The primary outcome was the improvement of the Oswestry Disability Index (ODI) score postoperatively and at six months follow-up. Results: Both mindfulness and physiotherapy groups showed significant improvement in ODI scores compared to the control group, with mean variations of 10.6 and 11.6 points, respectively, versus 4.9 points in the control group. There was no significant difference between mindfulness and physiotherapy (p = 0.52), but both were superior to medical care (p < 0.0001 for physiotherapy and p = 0.0007 for mindfulness). Conclusions: This study demonstrated that mindfulness therapy is more effective than usual care in improving postoperative outcomes for patients undergoing lumbar spine surgery. In our cohort, its efficacy was comparable to that of physiotherapy, making it a viable alternative, especially when access to healthcare services is restricted, as seen during the COVID-19 pandemic. Future research should validate the findings of this study and examine the long-term effects on surgical patient populations.
Effectiveness of Vortioxetine Treatment on Depression and Cognitive Functions in Patients with Alzheimer’s Disease: A 12-Month, Retrospective, Observational Study
Authors: García-Alberca José María , De La Guia Paz , Gris Esther , Mendoza Silvia , Lopez De La Rica María , Barbancho Miguel Ángel , Lara José Pablo , Blanco-Reina Encarnación
Published: August 2024

This study aimed to assess the effectiveness of vortioxetine for improving depressive symptoms, cognitive performance, daily and global functioning in patients with Alzheimer’s disease (AD) and major depressive disorder (MDD) in real-world clinical practice. We retrospectively identified 46 AD patients who had received treatment for 12 months with vortioxetine. Drug effects were evaluated at baseline, 4, 8, and 12 months. The primary endpoint was change from baseline in the Hamilton Depression Rating Scale (HDRS) and in the Cornell Scale for Depression in Dementia (CSDD) to month 12. Cognitive and daily and global functioning changes were also evaluated. Significant baseline-to-endpoint improvement in depressive symptom severity was observed (p < 0.0001). At month 12, the least-square mean (standard error) change score from baseline was −10.48 (±0.42) on the HDRS and −9.04 (±0.62) on the CSDD. Significant improvements in cognitive performance were observed for the Rey Auditory Verbal Learning Test, the Symbol Digit Modalities Test, the Letter Fluency Test, the Category Fluency Test, and the Trail Making Test-A. Patients also experienced significant improvements in daily and global functioning. Vortioxetine was safe and well tolerated. Patients with AD and MDD receiving vortioxetine showed meaningful improvements in depressive symptoms, cognitive performance, and daily and global functioning over the 12-month treatment period.
Uncemented Customized Hollow Stems in Tumor Endoprosthetic Replacement—A Good Opportunity to Protect the Adjacent Joint in Children?
Authors: Öztürk Recep , Streitbürger Arne , Hardes Jendrik , Hauschild Gregor , Guder Wiebke K. , Podleska Lars Erik , Nottrott Markus , Engel Nina Myline
Published: August 2024

This study aimed to retrospectively analyze the follow-up results of cases in which the adjacent joint was preserved using a custom-made uncemented short-stem design (hollow stem) with optional external flanches in tumor endoprosthetic replacement due to bone sarcomas in 13 patients (with an average age of 9.6 years) between 2017 and 2023. Reconstructions were proximal femur (n = 6), intercalary femur (n = 4), intercalary tibia (n = 2), and proximal humerus (n = 1) tumor prostheses. The hollow body was used distally in 10 of the megaprotheses, proximally in 1, and both proximally and distally in 2 of them. The average distance from the joints was 6 cm in stems with flanches and 11.8 cm in stems without flanches. No aseptic loosening or deep infection was observed during an average follow-up of 34 months. Except for one case with a tibial intercalary prosthesis that needed a revision, all cases were well osteointegrated and all lower extremity cases could bear full weight without pain. In cases where the remaining bone stock after bone resection is insufficient for a standard stem implantation, reconstruction with a patient-specific short hollow-stem design appears to be a good alternative to protect healthy joints with high prosthesis survival and low revision rates in the short-term follow-up.
The Impacts of Mining Industries on Land Tenure in Ghana: A Comprehensive Systematic Literature Review
Authors: Adjei Bridget , Tudzi Eric Paul , Owusu-Ansah Anthony , Kidido Joseph Kwaku , Durán-Díaz Pamela
Published: August 2024

The mining industry is indispensable for development, and in developing countries like Ghana, it drives economic growth by generating revenue and creating job opportunities for millions of people. Nonetheless, irresponsible mining results in the deprivation of people’s right to surface land, predominantly held under customary land tenure, with agriculture as the mainstay of livelihood. Mining activities have extensive repercussions for the land tenure system, resulting in the displacement of people, the loss of land rights, and reduced control and access to land. All these impact the economic, environmental, and social conditions of the people in the community. This systematic literature review thoroughly analyzes the impact of mining on land rights in Ghana, revealing complex dynamics, challenges, and possible remedies. To achieve this, 183 of an initial pool of 495 academic journals, research papers, books, reports, policies, and legal documents were critically reviewed. This research reveals the challenges faced by mining-induced communities because of the displacement which has resulted in the loss of ancestral lands and disruption to community life. The displacement is also coupled with economic disparities and social tension. Furthermore, the ripple effects of environmental degradation, such as deforestation, water pollution, noise, and air pollution, have dire consequences on land use and ownership, particularly for communities dependent on natural resources. This review brings to light various responses and effective strategies to mitigate the negative impacts of mining on land tenure in Ghana. These include community engagement strategies, corporate social responsibility initiatives, and legal reforms. This study reveals that mining compensation depends on the duration of the mining lease, therefore implying that the expropriated parties have reversionary interests in their lands. The procedure for giving the land back to the owner is not explicitly outlined in the law. This underscores the need for a review of the law governing mining, sustainable mining practices, and environmental management to safeguard the land tenure system. This review enlightens policymakers, researchers, mining enterprises, and local communities regarding the intricacies of this convergence, offering a foundation for well-informed decision making. It underscores the crucial importance of upholding sustainable development, social fairness, and responsible resource management within the framework of Ghana’s diverse land tenure traditions.
Land Use Thematic Maps Recommendation Based on Pan-Map Visualization Dimension Theory
Authors: Chen Yebin , Shi Zhicheng , Li Yaxing , Han Dezhi , Li Minmin , Zhao Zhigang
Published: August 2024

In the era of information and communication technology (ICT), the advancement of science and technology has led to a trend of diversification in map representation. However, the lack of professional knowledge means that there is still a challenge in determining the appropriate type of thematic map for land use expression. To address this issue, this paper proposes a knowledge recommendation method for land use thematic maps based on the theory of visualization dimensions. Firstly, we establish a knowledge ontology of land use thematic maps centered on spatial data, data characteristics, visualization dimensions, thematic map forms, and application scenarios. A land use thematic map knowledge graph is constructed through knowledge extraction and storage operations. Secondly, knowledge embedding is performed on the knowledge graph to enable the knowledge-based expression of map visualization elements. Finally, based on the knowledge elements of land use thematic expression, a similarity calculation model is established to calculate the similarity between input data and the spatial data characteristics, visualization dimensions, and application scenarios within the knowledge graph, deriving a comprehensive similarity result to achieve precise recommendation for land use thematic map forms. The results show that the method can provide a more accurate visualization reference for the selection of land use themes, meeting the diversified needs of land use thematic expression to a certain extent.
Territorial Spatial Resilience Assessment and Its Optimisation Path: A Case Study of the Yangtze River Economic Belt, China
Authors: Cui Jiaxing , Jin Han , Kong Xuesong , Sun Jianwei , Peng Yawen , Zhu Yuanyuan
Published: August 2024

Along with the rapid development of urbanization and industrialization, the carrying capacity of territorial space has been confronted with a serious crisis. Faced with many uncertain risks and unknown disruptions, it is important to proactively address the uncertainty of future developments in planning and to improve territorial spatial resilience (TSR). Based on the connotation of TSR, we build an assessment framework for TSR containing urban, agricultural and ecological space from three dimensions, including element, structure and function. Using a variety of methods such as the source-sink landscape index, land suitability assessment, and cropland pressure index, we assessed the TSR of the Yangtze River Economic Belt (YREB) from 2000 to 2020 and comprehensively analysed its spatial and temporal evolutionary characteristics. Through data analysis, we observe that the urban spatial resilience (RU) decreases and then increases, while the agricultural spatial resilience (RA) and the ecological spatial resilience (RE) show an increasing trend. The spatial clustering in TSR is apparent, and the distribution of hot and cold spots in RA and RE is reversed in the east–west direction. The changes in TSR are influenced by a combination of RU, RA and RE, which show unique geographical characteristics. Based on the average level and overall evolution of TSR, we divided the study area into five type zones and proposed development strategies for each of them.
The Impact of Formal and Informal Pronouns of Address on Product Price Estimation
Authors: de Hoop Helen , Boekesteijn Ward , Doolaard Martijn , van Wel Niels , Hogeweg Lotte , Hubers Ferdy
Published: August 2024

Previous literature has examined the effect of using a formal or informal second-person pronoun on consumers’ appreciation of an advertisement and the advertised product and their purchase intention. This is the first study that additionally examines the effect of the use of either pronoun on product price estimation. In a between-subjects web experiment, Dutch participants evaluated product ads in which either an informal or formal pronoun of address was used, or no pronoun of address at all (the control condition). Dependent variables were attitude towards the ad and the product, purchase intention, and price estimation. The results show that the use of the formal pronoun leads to a higher estimate of the price of the advertised product, while a higher price estimate may increase the purchase intention.
Exploring the Th2 Response in Obesity and Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A Potential Modulator of the Renin-Angiotensin System (RAS) Pathway in Hypertension Development
Authors: Méndez-García Lucía Angélica , Escobedo Galileo , Baltazar-Pérez Itzel , Ocampo-Aguilera Nydia Angélica , Arreola-Miranda José Alfonso , Cid-Soto Miguel Angel , Alfaro-Cruz Ana , González-Chávez Antonio , Ocaña-Guzmán Aquiles Ranferi , Solleiro-Villavicencio Helena
Published: August 2024

Non-alcoholic fatty liver disease (NAFLD), now referred to as metabolic dysfunction-associated steatotic liver disease (MASLD), is alarmingly increasing alongside the cases of obesity worldwide. MASLD is an underestimated metabolic abnormality closely linked with a higher risk of developing systemic arterial hypertension (SAH). However, the underlying mechanism of association between MASLD and SAH remains unknown. Inflammation may link these two entities by regulating the renin-angiotensin system (RAS). For this reason, in this study, we evaluated the hepatic expression of a cytokine profile and critical molecules in the RAS pathway in patients with morbid obesity and MASLD, both with SAH. We found a statistically significant correlation between ACE levels and the cytokines IL-4, IL-10, and IL-13 of Th2 response. Furthermore, according to a multiple linear regression analysis, the cytokines IL-4 and IL-13 were the best predictors of ACE levels. Moreover, we observed increased hepatic IL-13 expression in patients with morbid obesity, MASLD, and SAH compared to those without SAH. These results allow us to propose, for the first time, that the Th2 response, through regulating the RAS, could play a critical role in developing SAH in individuals with MASLD and obesity.
Epiphytic Yeasts from South Romania for Preventing Food Microbial Contamination
Authors: Corbu Viorica Maria , Dumbravă Andreea Ștefania , Gheorghe-Barbu Irina , Csutak Ortansa
Published: August 2024

Epiphytic yeasts represent an important source for the development of novel strategies aiming to combat food microbial contamination. The present study deals with the characterization of nine yeast strains belonging to Starmerella, Candida, Metschinikowia, Lachancea, Kodamaea and Pichia genera, isolated from the surface of plants from the Botanical Garden “Dimitrie Brandza” (Bucharest, Romania) for use as antimicrobial and probiotic agents. The tests involved the determination of the safe status, cell growth under stress conditions, and activity against pathogenic Candida and bacteria strains, respectively, as well as phytopathogenic filamentous fungi and lipolytic activity. None of the nine strains showed all the characteristics for virulence and pathogenicity, with the rare positive results being explained rather by their adaptability to the habitats of origin. The strains Lachancea thermotolerans CMGB-ST12 and Kodamaea ohmeri CMGB-ST19 grew at 37 °C; Metschnikowia reukaufii CMGB-ST21.2, M. reukaufii CMGB-ST.8.1 and M. reukaufii CMGB ST10 grew in the presence of 10% NaCl, while L. thermotolerans CMGB-ST12 and K. ohmeri CMGB-ST19 tolerated both acidic and alkaline pH values well (3.0 to 12.0). The studied yeast strains showed good antimicrobial activity against Candida krusei, Candida albicans and Gram-negative bacterial strains, with K. ohmeri CMGB-ST19 and Pichia membranaefaciens CMGB-ST53 inhibiting up to 100% the development of filamentous fungi. All the strains produced lipases for tributyrin hydrolysis, the best producer being Starmerella bombi CMGB-ST1, and only Candida magnoliae CMGB-ST8.2 tested positive against other probiotic yeasts. Overall, our nine yeast strains show high potential for industrial applications, for obtaining probiotic products and for preventing the development of a wide range of microbial food contaminants.
Attempted Synthesis of the Pseudomonas aeruginosa Metabolite 2-Benzyl-4(1H)-quinolone and Formation of 3-Methylamino-2-(2-nitrobenzoyl)-4H-naphthalen-1-one as an Unexpected Product
Authors: Angelov Plamen , Mollova-Sapundzhieva Yordanka , Nedialkov Paraskev
Published: August 2024

The unusual reactivity of key enamine intermediates led to the formation of 3-methylamino-2-(2-nitrobenzoyl)-4H-naphthalen-1-one as an unexpected product in an attempted synthesis of the P. aeruginosa metabolite 2-benzyl-4(1H)-quinolone. Although the synthesis of the natural product has not been successful, this methodology allows for the easy preparation of novel derivatives carrying a carboxamide moiety at the C3 position.
Kinetic of Light Transmission during Setting and Aging of Modern Flowable Bulk-Fill Composites
Authors: Ilie Nicoleta , Högg Christof
Published: August 2024

The current development of dental materials aims to improve their properties and expand their clinical application. New flowable bulk-fill composites have been released which, unlike what was previously common in this material category, are intended to be used alone and without a top layer, in various cavities. The study compares their kinetic of light transmission during monomer-to-polymer conversion on a laboratory-grade spectrometer, as well as their elastoplastic and aging behavior under simulated clinical conditions. Major differences in the kinetic of light transmission was observed, which is related to the degree of mismatch between the refractive indices of filler and polymer matrix during polymerization and/or the type of initiator used. Compared to the literature data, the kinetic of light transmission do not always correlate with the kinetic of functional group conversion, and therefore should not be used to assess polymerization quality or to determine an appropriate exposure time. Furthermore, the initial mechanical properties are directly related to the volumetric amount of filler, but degradation during aging must be considered as a multifactorial event.
The Role of a New Stabilizer in Enhancing the Mechanical Performance of Construction Residue Soils
Authors: Chen Xin , Yu Jing , Yu Feng , Pan Jingjing , Li Shuaikang
Published: August 2024

Urban construction generates significant amounts of construction residue soil. This paper introduces a novel soil stabilizer based on industrial waste to improve its utilization. This stabilizer is primarily composed of blast furnace slag (BFS), steel slag (SS), phosphogypsum (PG), and other additives, which enhance soil strength through physical and chemical processes. This study investigated the mechanical properties of construction residue soil cured with this stabilizer, focusing on the effects of organic matter content (Oo), stabilizer dosage (Oc), and curing age (T) on unconfined compressive strength (UCS). Additionally, water stability and wet–dry cycle tests of the stabilized soil were conducted to assess long-term performance. According to the findings, the UCS increased with the higher stabilizer dosage and longer curing periods but reduced with the higher organic matter content. A stabilizer content of 15–20% is recommended for optimal stabilization efficacy and cost-efficiency in engineering applications. The samples lost their strength when immersed in water. However, adding more stabilizers to the soil can effectively enhance its water stability. Under wet–dry cycle conditions, the UCS initially increased and then decreased, remaining lower than that of samples cured under standard conditions. The findings can provide valuable data for the practical application in construction residual soil stabilization.
Characterization and Making Techniques of Calcareous Construction Materials for Phaya Thon Zu Temple in Bagan Historical Area, Myanmar
Authors: Yang Hye Ri , Lee Gyu Hye , Kim Dong Min , Lee Chan Hee
Published: August 2024

The calcareous materials used in constructing the Phaya Thon Zu temple at the Bagan historical sites in Myanmar are mortars, plasters, and stuccos. Among them, the mortars and plasters are a mixture of original and new materials used for recent conservation treatments. In this study, the making techniques were examined through analysis of calcareous materials by production period. All calcareous materials have a mineral composition similar to soil, except calcite. Stuccos have the most refined aggregates, homogeneous particle size, and the highest lime and organic contents. They were designed to improve ease of carving and weathering resistance, considering the unique characteristics of the stuccos. Because all calcareous materials were mixed with soil, the origin of the clay materials was analyzed. It was concluded that the mortars were produced by mixing clay and sandy soil, and the original mortars showed characteristics similar to soil. It is highly possible that sandy soil from around the Htillominlo temple was used to produce new plasters, and it is estimated that a mixture of clay soil was used for the original plasters and stuccos. A clear provenance interpretation of the original and raw materials used for each construction and the mixing ratio of clay materials need to be discussed through experiments, along with the estimated provenance area of the raw calcareous materials.
Axial Crushing and Energy Absorption Integrated Design of Modular Filled Double-Hat Beam Composite Structures
Authors: Yi Xiaojian , Hu Lin , Li Qiqi , Tang Yong
Published: August 2024

In order to study the influence of modular filled and composite material forms on the axial crushing and energy absorption properties of structures, modular filled composite structures were constructed, and innovatively applied to the inner side of double-hat beam (DHB) structures in automobiles. The modular filled structures comprise hexagonal, quadrilateral, and triangular sections. By analyzing the collision performance of modular filled DHB structures, significant enhancements were observed in both the sectional characteristics and the specific Mean Crushing Force of modular filled DHBs compared to the conventional double-hat beam structure. These advancements notably improved the plastic deformation characteristics of the structures. Additionally, dynamic weightlessness experiments were conducted to validate the accuracy of the simulation model. Among the proposed schemes, namely QU-5, HE-5, and TR-5, notable improvements in crashworthiness were identified. Specifically, crashworthiness indicators increased by 32.54%, 78.9%, and 116.53%. Compared with other thin-walled structures, modular filled composite DHBs have advantages in axial crushing and energy absorption. By optimizing layout characteristics, the modular filled structures will achieve significant lightweight and energy absorption performance improvements. This work has clear reference value for automotive engineers and scholars to further explore the axial crash safety, platform modularization, and lightweight design of vehicles.
Improvement in Mechanical Properties of Completely Decomposed Granite Soil Concrete Fabricated with Pre-Setting Pressurization
Authors: Song Yi , Yue Zhongqi Quentin , Ding Yanlu
Published: August 2024

This paper investigates the effectiveness of applying continuous high-compression pressure on the initial setting of fresh concrete to produce hardened concrete materials with excellent mechanical properties. A novel experimental apparatus was self-designed and used for the pre-setting pressure application. The utilization of the completely decomposed granite (CDG) soil as an alternative aggregate in concrete production was also explored. A total of twenty-eight specimens were fabricated using two types of fine aggregates, six mix ratios, two initial pressure values, and two distinct durations of the initial pressure application. The density and uniaxial compressive strength (UCS) of the specimens were examined to evaluate their mechanical qualities, while micro-CT tests with image analysis were used to quantify their porosity. The results indicated that the 10 MPa initial pre-setting pressurization can effectively eliminate the excess air and voids within the fresh concrete, therefore enhancing the mechanical properties of the hardened concrete specimens of various types. Compared with non-pressurized specimens, the porosity values of pressurized specimens were reduced by 73.11% to 86.53%, the density values were increased by 1.43% to 8.31%, and the UCS values were increased by 8.42% to 187.43%. These findings provide a reference for using a continuous high pre-setting compression pressure and using CDG soil as an aggregate in the fabrication of concrete materials with improved mechanical performance.
Steady-State Fault Propagation Characteristics and Fault Isolation in Cascade Electro-Hydraulic Control System
Authors: Zhang Yang , Zhou Rulin , Meng Lingyu , Shi Jian , Ba Kaixian
Published: August 2024

Model-based fault diagnosis serves as a powerful technique for addressing fault detection and isolation issues in control systems. However, diagnosing faults in closed-loop control systems is more challenging due to their inherent robustness. This paper aims to detect and isolate actuator and sensor faults in the cascade electro-hydraulic control system of a turbofan engine. Based on the fault characteristics, we design a robust unknown perturbation decoupling residual generator and an optimal fault observer specifically for the inner and outer control loops to detect potential faults. To locate the faults, we analyze the steady-state propagation laws of actuator and sensor faults within the loops using the final value theorem. Based on this, we establish the minimal-dimensional fault influence distribution matrix specific to the cascade turbofan engine control system. Subsequently, we construct the normalized residual vectors and monitor its vector angles against each row of the fault influence distribution matrix to isolate faults. Experiments conducted on an electro-hydraulic test bench demonstrate that our proposed method can accurately locate four typical faults of actuators and sensors within the cascade electro-hydraulic control system. This study enriches the existing fault isolation methods for complex dynamic systems and lays the foundation for guiding component repair and maintenance.