bluuebunny/crossref_metadata_2025 huggingface dataset:
Upregulation of lncRNA SPINT1-AS1 by miR-200c/ZEB1 axis inhibits metastasis of breast cancer cells
Authors: Liu Chunshan , Du Kunpeng , Ai Meiling , Liu Wei , Liu Rongqiu , Zhang Fangmei , Dai Zili , Huang Xiuting , Xie Tao , Huang Xiaoting , Yuan Yawei , Wang Baiyao , Tian Yunhong
Published: December 2022

Background
Breast cancer is the most frequent and lethal malignancy among females worldwide. Metastasis crucially affects breast cancer-related deaths. Long noncoding RNAs (lncRNAs) are known to perform a crucial function in the regulation of biological processes in a variety of malignancies. The aim of this study was to evaluate the unidentified function played by the lncRNA SPINT1-AS1 and the relevant mechanism in the modulation of breast cancer-related metastasis.
Methods
Techniques such as immunohistochemistry (IHC) staining, western blotting, quantitative real-time polymerase chain reaction (qRT-PCR), and immunofluorescence (IF) were applied to evaluate RNA and protein expression profiles. In vitro Transwell and wound healing tests, as well as in vivo lung metastasis experiments, were conducted to validate the cell's ability to invade and migrate. To identify the transcription factors that are involved in lncRNA SPINT1-AS1 interactions, the Chromatin Immunoprecipitation(ChIP) and dual-luciferase reporter assays were carried out. Finally, the role of lncRNA SPINT1-AS1 was evaluated in patients with breast cancer.
Results
lncRNA SPINT1-AS1 and miR-200c showed low levels of expression in breast cancer cell lines. Furthermore, the overexpression of lncRNA SPINT1-AS1 or miR-200c in the cell lines decreased the tumor cell invasion. Mechanistically, miR-200c induced the overexpression of the lncRNA SPINT1-AS1 via the mechanism of causing zinc finger E-box-binding homeobox members 1 (ZEB1) to bind directly to the promoter DNA of the lncRNA SPINT1-AS1. The miR-200c mediated upregulation of the lncRNA SPINT1-AS1 suppressed breast cancer cell metastasis via the STAT3 signaling pathway.
Conclusion
lncRNA SPINT1-AS1, which was up-regulated by the miR-200c/ZEB1 axis, performs a crucial function in inhibiting metastasis of breast cancer cells via the Phosphorylation-signal transducer and activator of transcription 3(p-STAT3) pathway and can be a novel prognostic and treatment target for the disease.
A Retrospective Study of All-Ceramic Onlay Restorations
Authors: Domanic Kubra Yildiz , Aslan Yilmaz Umut , Ozkan Yasemin
Published: December 2022

Objectives: To evaluate the survival rate, failure, and clinical quality of all ceramic Onlay restorations retrospectively.
Methods: Restorations placed during the period September 2010 - April 2021 at Marmara University Dentistry Faculty Department of Prosthodontics were included. Patients with parafunctional habits were excluded from the study. In 62 patients, 115 onlay restorations were examined. The number of restoration failures and reasons for failure was recorded. The remaining onlay restorations were evaluated by CDA criteria (color match, anatomical form, marginal discoloration, marginal integrity, and surface texture) by two clinicians after 1–12 years. Patients also evaluated their restorations in five categories (color, surface, fonation, hygiene, and bite efficiency) on a scale of 1–10.
Results: A survival rate of 87.9 % was recorded. 14 (12.1%) of the 115 restorations had to be replaced. The main reasons for failure were 7 ceramic fractures (6.0%), 6 decementation (5.2%), four endodontic treatment needs (4.3%) and 2 extensive restoration needs (1.7%), 1 tooth fracture (0.8%). Conversely, patient satisfaction score was founded mostly over 8 and none of the patients rated under 3.
Conclusions: All ceramic Onlay restorations are an acceptable and predictable treatment alternative in general dental practice. In addition, the location of teeth in the dental arch and marginal integrities of teeth influenced restoration failures directly.
Clinical Significance: All ceramic Onlay restorations show a good clinical performance for up to 11 years.
FOXP3 promotes cell proliferation and metastases via the Wnt5a/CaMKII signaling pathway in choroidal melanoma
Authors: Yuan Yingying , Ma Qingyue , Gong Ruining , Wang Wenying , Yao Ningning , Zhao Han , Lei Ke , Fu Weiwei , Sui Aihua , Yu Xiaoling , Luo Wenjuan
Published: December 2022

Background:Choroidal melanoma (CM) accounts for 70% of uveal melanomas and is prone to metastasize and invade. Previous studies have reported that forkhead box protein 3 (FOXP3) is associated with carcinogenesis, however, the effect of FOXP3 on CM remains unclear. The purpose of the study is to explore the role of FOXP3 in the progression of CM and to elucidate its related mechanisms.Methods:FOXP3 protein expression was detected in CM clinical specimens and CM cells. We then established a cell line with stable FOXP3 knockout as well as a cell line that transiently overexpressed FOXP3, and their transfection efficiencies were detected by Western blotting (WB). The effects of FOXP3 on cell biological functions and epithelial-mesenchymal transition (EMT) in CM were verified via the CCK-8 assay, monoclonal formation assay, migration and invasion assays, WB and tumorigenesis assay in nude micein vivo. We also demontrated that FOXP3 promoted CM development through the Wnt5a/CaMKII signaling pathway.Results:The level of FOXP3 was found to be upregulated in CM clinical specimens and CM cells. The overexpression of FOXP3 promoted the proliferation, migration, invasion, and EMT process of CM cellsin vitro, while the knockdown of FOXP3 inhibited these cell functionsin vitroand tumor growthin vivo. In addition, FOXP3 was found promoting the progression of CM, including EMT, through the Wnt5a/CaMKII signaling pathway.Conclusion:This study demonstrated that FOXP3 promoted the development of choroidal melanoma through the Wnt5a/CaMKII signaling pathway as an oncogenic factor of CM, and thereby provides a novel potential target for the pathogenesis of CM.
NOMA Resource Allocation Method Based on Prioritized Dueling DQN -DDPG Network
Authors: Liu Yuan , Li Yue , Li Lin , He Mengli
Published: December 2022

In the mobile communication system, non-orthogonal multiple access (NOMA) technology is introduced to improve spectrum efficiency. Because the combination of users and the transmission power of each user are very important to the performance of NOMA system, the resource allocation technology of NOMA system has been widely studied. In recent years, scholars have introduced deep reinforcement learning network for user grouping and power allocation, which can effectively reduce the computational complexity and improve the system sum rate. However, the traditional algorithm based on DQN network still has the problems of slow convergence speed and low training stability, and the uniform sampling method in the sample playback process has the problem of low sampling efficiency. To address these problems, this paper proposes a priority-based user grouping and power allocation method of NOMA system optimized by Dueling DQN-DDPG, which can effectively improve the convergence speed and training stability. Firstly, in the user grouping stage, a user grouping network based on Dueling DQN is proposed. This network considers both the state value and the action value in the whole connection layer. The two values compete with each other, and then they are summed up and re-evaluated. The proposed network can effectively improve the stability of the traditional DQN network training process and speed up the training convergence. Secondly, considering the continuity of power value, DDPG network, which is suitable for dealing with continuous action space, is adopted in the power allocation stage, which can avoid the power quantization error. Finally, the priority sampling based on TD-error is combined with Dueling DQN network and DDPG network respectively, which can ensure random sampling and improve the replay probability of important samples. Simulation results show that the priority based Dueling DQN -DDPG algorithm proposed in this paper can greatly improve the convergence speed of sample training. At the same time, this scheme has the advantage of priority sampling, which can improve the learning speed and make the training process more stable. Compared with the traditional DQN algorithm, the convergence speed of the proposed algorithm is nearly doubled, and the training process is more stable, but the computational complexity is only increased by about 15%.
Phenotypes of Painful TMD in Discordant Monozygotic Twins According to a Cognitive-Behavioral-Emotional Model: A Case-Control Study
Authors: Magri Laís Valencise , Melchior Melissa de Oliveira , da-Silva Graziela Valle , Gherardi-Donato Edilaine Cristina da Silva , Leite-Panissi Christie Ramos Andrade
Published: December 2022

Objectives

this case-control study’s objective was to investigate variables based on a cognitive-behavioral-emotional model related to the development of painful temporomandibular disorders (TMD) in a sample of monozygotic twins discordant for the condition.

Materials and Methods

20 monozygotic twins (10 pairs discordant for painful TMD), aged between 18 and 55 years, were studied. The diagnosis of painful TMD was determined according to the Diagnostic Criteria for Temporomandibular Disorders - Brazilian Portuguese (DC/TMD). The cognitive-behavioral-emotional variables analyzed were sociodemographic profile, pain sensitivity (pain threshold to pressure, allodynia, and hyperalgesia), oral behaviors, pain vigilance and awareness, pain catastrophizing, central sensitization, stress, anxiety, depression, alexithymia, mindfulness facets, sleep quality, pain control, pain intensity and interference, trigeminal and extratrigeminal pain areas.

Results

According to the adjusted regression model, there was an increased chance of TMD with: an increasing left-sided masseter face pain sensitivity score (OR = 3.29;95%CI=(0.17–62.8),p = 0.428); an increasing total pain catastrophizing score (OR = 1.08; 95%CI=(0.64–1.8),p = 0.776); an increasing score of difficulty in externalizing feelings (OR = 1.61;95%CI=(0.13–2.9),p = 0.539); and a scoring of the distraction facet of the FFMQ scale (OR = 4.65;95%CI=(0.39–55.7),p = 0.225).

Conclusions

from the cognitive-behavioral-emotional model studied in this case-control study of monozygotic twins discordant for painful TMD, painful sensitivity in the face, catastrophizing pain, difficulty in externalizing feelings, and the distraction facet (mindfulness) are variables that increase the chance of developing painful TMD.
Clinical Relevance: This study with discordant monozygotic twins allows phenotype analyses, minimizing genetic and social influences. The results elucidate that cognitive-behavioral-emotional variables increase the chance of developing painful TMD, despite genetic influences.
Clade delineation and isolate-specific variability of Candida albicans exometabolome
Authors: ALABAN Leovigildo Rey , Bunescu Andrei , GHANEM Joséphine ABI , BEQUET Frédéric , KOSMALA Daria , BOUGNOUX Marie-Elisabeth , d'Enfert Christophe , THOMAS Vincent
Published: December 2022

Candida albicansis a fungal pathobiont that relies on a vast molecular arsenal to navigate the host milieu and to confront the host immune defense. These molecular exchanges with the environment and the host are powered by a highly plastic metabolism, which is increasingly shown to vary between isolates. Unfortunately, metabolic variations are difficult to define inC. albicansas isolates (strains) are diverse and closely related. To overcome this constraint, we developed a high-throughput strategy to probe exometabolome variation inin vitrocultures of 95 clinical isolates from 12 major and five putative genetic clusters (clades). The workflow allows for the batch analysis of these isolates with robust replication (six or more replicates). Based on NMR (nuclear magnetic resonance) analysis of culture supernatants, we have shown delineation between clades, prominently clade 13 (corresponding to the so-calledC. africanaisolates) being metabolically distinct from the rest partly due to non-consumption of trehalose and weak utilization of choline. Further, using pairwise comparison, we could demonstrate that clades are delineated. We have also observed isolate-specific variation within clades, particularly in metabolites involved in central carbon metabolism. These results revealC. albicansas a consortium of isolates with divergent metabolic phenotypes.
Fish-derived Probiotic Improves Growth Performance and Pathogen Resistance of Juvenile Grass Carp (Ctenopharyngodon idella) by Modulating Keystone Taxa and Enhancing Microbial Interactions
Authors: Qi Xiaozhou , Xue Mingyang , Wang Gaoxue , Ling Fei
Published: December 2022

Host-derived probiotics are bacteria isolated from the host's gut to improve the host’s growth and health. With more stringent antibiotic prohibitions in animal production, in-feed probiotics are becoming an appealing alternative to antibiotics in aquaculture. To explore the effects of Pseudomonas monteilii JK-1 on grass carp growth performance and disease resistance, 180 apparently healthy juvenile grass carp (3 ± 0.05 g) were randomly separated into 2 groups, each of which had 3 duplicates and 30 grass carp per replicate. Fish were fed with basal diets (control) or basal diets supplemented with P. monteilii JK-1 (1 × 107 CFU/g diet, PM-JK1) for 8 weeks. Results showed that P. monteilii JK-1 significantly increased the weight gain (WG), specific growth rate (SGR), survival rate and significantly reduced the pathogen load in grass carp (P < 0.05). Moreover, P. monteilii JK-1 supplementation significantly improved the expression of interleukin 1β (IL-1β), interleukin 10 (IL10), tumor necrosis factor alpha (TNF-α), and transforming growth factor beta (TGF-β) in head kidney and gut (P < 0.05). Furthermore, dietary supplementation with P. monteilii JK-1 significantly enhanced the activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) in liver and gut (P < 0.05). The results of high-throughput sequencing revealed that P. monteilii JK-1 showed no significant influence on the composition of gut bacteria, but prevented changes of microbial community caused by A. hydrophila infection. Additionally, a network-based approach was used to analyze the influence of P. monteilii JK-1 on the interspecies relationships among the gut microbiome. The results showed that P. monteilii JK-1 supplementation improved the complexity of the gut ecological network. Further analysis found that Cetobacterium was the keystone microbiota in maintaining interspecies interactions and the stability of the gut network. Finally, we used a partial least squares path model to prove that P. monteilii JK-1 did not directly improve growth performance and pathogen resistance but rather by regulating keystone taxa and gut network stability. These results suggest that P. monteilii JK-1 could be used as a feed supplement to improve the growth performance and pathogen resistance of grass carp.
Forecasting the effects of interest groups on Greek economy
Authors: Papadakis Haris , Atsalakis George S.
Published: December 2022

From the modern bibliography there are many significant reports and indications for the action of special interest groups in Greece mainly after the fall of the court in 1974. Based on the theory of Olson as described in his book “The Rise and Decline of Nations” where developed analytically the implications of the special interest group’s action in a country, focus in the economic factor. With a thorough bibliographic survey, are recorded all the variables that have been used in the research for the impact of the interest groups. After the data for the case of Greece were collected and the normalization was done where it was necessary, the correlation between the variables was first checked. Then the Principal Component Analysis methodology was followed in order to arrive at the fewest variables for the study of the interest groups economic impact. Afterwards, the input and output variables separated, selected a suitable forecasting model of soft computing, the Adaptive Neural Fuzzy Inference System (ANFIS) for the study of the special interest groups impact in the Greek economy. ANFIS is a hybrid model which combines the advantages of Neural Network and the Fuzzy logic. Trying out all the different configurations of the model, as well as the different membership functions the corresponding results were recorded. For each result that emerged, the required evaluation was done, which has as its main criterion the low arithmetical errors of the model. The optimum results emerged from the ANFIS forecasting model, are presented in details along with the rules of the fuzzy logic and the corresponding diagrams, that confirm the success of the prediction.
Domain Adversarial Convolutional Neural Network Improves the Accuracy and Generalizability of Wearable-based Sleep Assessment Technology
Authors: Nunes Adonay S. , Patterson Matthew R. , Gerstel Dawid , Khan Sheraz , Guo Christine C. , Neishabouri Ali
Published: December 2022

Wearable accelerometers are widely used as an ecologically valid and scalable solution for long-term at-home sleep monitoring in both clinical research and care. The levels of accuracy with accelerometry-based sleep outcomes, however, have not improved much for the last 40 years. In this study, we applied deep-learning convolutional neural network (CNN) models to this task and demonstrated that this new model outperformed existing sleep algorithms in classifying sleep-wake and estimating sleep outcomes based on wrist-worn accelerometry. We further showed that, using a domain adversarial technique, this model generalized well to another dataset based on different wearable devices and activity counts, achieving an accuracy of 80.1 (sensitivity 84% and specificity 58%). Compared to the commonly used sleep algorithms, this model, termed DAsleepCNN, resulted in the smallest error in wake after sleep onset (WASO) and sleep efficiency (SE) outcomes. As wearable-based digital health technologies are increasingly used in clinical trials and care, improving the accuracy and generalizability of sleep algorithms for wrist-worn wearable data are of utmost importance. We here demonstrated that domain adversarial convolutional neural networks can improve the overall accuracy, especially the specificity, of sleep-wake classification using wrist-worn accelerometer data, substantiating its use as a scalable and valid approach for sleep outcome assessment in real-life.
Synthesis, biological evaluation, molecular docking and structure-activity relationship of caffeine derivatives
Authors: Khan Siraj , Buğday Nesrin , Yaşar Şeyma , Rehman Asim. ur. , Haq Ihsan Ul , Yaşar Sedat
Published: December 2022

A series of 8-(hetero)aryl caffeine was synthesized by C-H bond activation reaction using Pd-NHCs complexes as a catalyst. The derivatives were screened for their antioxidant, antimicrobials, and enzyme inhibitory activities. Furthermore, done their in-silico study. The 4a, 4b, 4e, 4f, 4g and 4n showed significant Total Antioxidant Capacity (TAC) of 64.03, 50.87, 70.02, 98.14, 71.81, 45.48 and 44.28 µg AAE/mg, respectively. The 4a, 4b, 4d, 4e, 6h, 4i, 4j, 4k and 4l were found active against Staphylococcus aureus at a minimum inhibitory concentration of 25, 12.5, 12.5, 12.5, 12.5, 6.25, 6.25, 12.5, 6.25 and 6.25 µg/ml, respectively. Some derivatives displayed activity against Escherichia coli, Bacillus subtilus, Klebsiella pneumonae and Pseudomonas auregenosa. A good activity was exhibited against Alternaria solani among five fungal strains. All the compounds (4a-4n) showed excellent protein kinase inhibitory activity except 4e, 4g and 4n. Additionally, derivatives showed α-Amylase enzyme inhibition potential (IC50 = 1.49 ± 0.317 to 7.44 ± 0.156 µg/ml) compared to standard Acarbose (IC50 = 4.34 ± 0.333 µg/ml). The 4b, 4d, 4j, 4m and 4n compounds displayed good α-Glucosidase inhibitory potential. Molecular modelling was done for protein kinase, α-Amylase, and α-Glucosidase enzymes. The results of these activities proved the caffeine derivatives to be bioactive.
Illuminating health aspects for immigrant Thai women in Swedish transnational marriages
Authors: Pongthippat Weerati , Östlund Gunnel , Darvishpour Mehrdad , Kijsomporn Jureerat , Gustafsson Lena-Karin
Published: December 2022

Background:
Women who are migrants experience discrimination and face major risks, including sexual exploitation, trafficking, and violence, which all affect their health and well-being.
This study explored critical health incidents resulting from marriage migration and the consequences experienced by immigrant Thai women in everyday life.
Methods: A qualitative explorative approach with in-depth interviews was used. Forty immigrant Thai women who currently or previously had a Swedish spouse were recruited for the study. An inductive critical incident technique was used to collect and analyze the data as the first step. In a second deductive step, the Newman system model was used when categorizing health dilemmas.
Results: The women reported 438 critical health incidents in five main areas: psychological health dilemmas included emotional abuse, feeling overwhelmed due to family responsibilities and the stress of leaving family behind. Sociocultural health dilemmas included transnational family duties or not performing family duties. Physiological health dilemmas included experiencing physical violence and environmental, domestic or work accidents. Developmental health dilemmas included failing health, difficulties in upholding the duties expected of a spouse in the target culture and caring for an elderly husband. Spiritual health dilemmas included critical incidents in which the women perceived themselves to have failed in their hopes and duties as a wife, which intensified their dependence on faith, particularly the Buddhist concept of karma.
Conclusion: The health and welfare practices that are included in marriage migration practices in Thailand and western countries, along with civil organizations such as Buddhist cultural associations in foreign countries that support immigrants, would benefit from the multicultural knowledge revealed by the present study. If accepted, this knowledge could facilitate healthcare and welfare support for women experiencing marriage migration.
"Damit Kirche weiterhin diskursfähig bleiben kann, wird sie sich massiv verändern müssen." : Interview zur Berufung von Prof. Dr. Christine Wenona Hoffmann (Praktische Theologie)
Authors: Hoffmann Christine Wenona , Dücker Malte
Published: December 2022

Im Wintersemester 2022/23 begrüßt der Fachbereich Christine Wenona Hoffmann als neu berufene Professorin für Praktische Theologie. Ein Interview über praktisch-theologische Forschung und Lehre zwischen Theorie und Praxis und die gesellschaftliche Relevanz von Kirche in der Gegenwart
MIGRASI PENGAJIAN KONVENSIONAL KE PENGAJIAN VIRTUAL DI PESANTREN
Authors: Masruroh Sayidah Afyatul , Muhid Abdul
Published: December 2022

This article aims to discuss the movement of conventional recitations to virtual recitations in Islamic boarding schools. This article is the research result of a literature review on the transformation of the virtual recitation model through new media in the pesantren scope. This study aims to uncover the adaptation of pesantren toward the development of information and communication technology due to modernization and globalization. Besides, it also focuses on the efforts of pesantren in concerning the culture created by the latest media in pesantren to maintain it. The results of this study indicate that the advancement of information and communication technology in pesantren provides a great opportunity for pesantren to adapt by transforming the recitation system virtually, so that pesantren as a symbol of Islamic civilization is still recognized by modern society as a religious institution. The researcher argues that currently pesantren must open themselves to the advancement of information and communication technology through latest media, so that pesantren graduates are also able to develop Islamic syiar activities by utilizing latest media, which impacts to equip them to compete with global community.
definición-concepción de historia para combatir el eurocentrismo y la ambigüedad
Authors: Ortiz Delgado Francisco Miguel
Published: December 2022

Se hace una crítica de la concepción de “historia” que la entiende como el conjunto de hechos humanos “importantes”, “trascendentes”, “relevantes” y “transformativos” y que, por esto mismo, serían los únicos que pueden y deben ser recordados. Se critica esta concepción porque generalmente implica un eurocentrismo al solo sancionar como constitutivos de la “historia” los hechos que la cultura “occidental” (eurocéntrica) considera “importantes”, “trascendentes”, “transformativos”, tanto en los planos regionales como en el mundial (descubrimientos científicos, desarrollos capitalistas, avances democratizadores, etcétera). En un primer momento reflexionamos sobre la problemática que implica la ambigüedad y polisemia del vocablo historia. En un segundo momento se propone, cuestión eje de este texto, que la definición-concepción de historia como “el conjunto de los hechos pretéritos realizados por el ser humano” es la que mejor permitirá eliminar el eurocentrismo generalizado. Por último, se amonesta la noción historiográfica de “historia mundial” predominante en la actualidad y los textos producidos bajo tal noción, como los de Yuval Noah Harari o Peter Frankopan, por aparentar ser mundiales-plurales, cuando son aún eurocéntricos, tecnocéntricos y colonizadores.
Analisis terhadap biro jodoh online: Kebutuhan atau tuntutan
Authors: Azwinda Devi
Published: December 2022

Konsep perjodohan terus berubah di tengah perkembangan zaman. Perkembangan era digital membuka peluang baru untuk beragam situs internet yang menawarkan layanan biro jodoh secara online. Biro jodoh online memiliki banyak metode, ada yang biasa dan ada pula yang berbasis syari’at Islam. Penelitian ini berfokus pada biro jodoh sebuah kebutuhan atau tuntutan dan tawaran solusi dari layanan aplikasi biro jodoh online. Penelitian ini menggunakan kajian kualitatif dengan metode deskriptif analitis. Hasil penelitian menunjukkan bahwa sejauh ini biro jodoh online masih menjadi kebutuhan sebagai solusi untuk mencari pasangan, dikarenakan biro jodoh online merupakan bentuk terobosan baru dalam hal pencarian jodoh. Biro jodoh online juga menawarkan solusi yaitu bantuan jasa bagi mereka yang mencari pasangan atau jodoh ketika seseorang kesulitan mencari pasangan hidup bagi yang membutuhkannya.The concept of matchmaking continues to evolve with the times. The development of the digital era opens up new opportunities for various internet sites that offer online matchmaking services. The online matchmaking bureau has many methods on each website or application site, some are ordinary and some are based on Islamic law. This study focuses on a matchmaking agency for a need or demand and offers solutions from an online matchmaking bureau application service. This study uses a qualitative study with a descriptive analytical method. The results show that so far online matchmaking bureaus are still a necessity as a solution for finding a partner, because online matchmaking bureaus are a new form of breakthrough in terms of finding a mate. The online matchmaking bureau also offers a solution, namely service assistance for those who are looking for a partner or mate when someone is having trouble finding a life partner for those who need it.
Development of e-wallet application “DASIGU” - based teaching factory
Authors: Vachruddin Vrisko Putra , Hamid Abdulloh , Nasril Nashudi
Published: December 2022

The trend of non-cash or cashless payments through e-wallet applications is increasing because the application presents the ease of transacting features accompanied by discounts and cashback that are attractive to its users. Not realizing it increases people's interest in transacting and shopping both it increases their interest in transacting and shopping online and offline, which will encourage the country's economic growth. So many start-ups and institutions are vying to develop digital wallet applications. Likewise, SMK YPM 3 Taman Sidoarjo is an educational institution based on vocational or expertise to support teaching factory learning and facilitate consumers in transacting it is necessary to develop e-wallet applications in schools. The purpose of this study is to provide an overview of the importance of developing e-wallets in schools aimed at improving the quality of schools through online transactions on products by students. This type of research and development (RD) with a 4D development model. The stages in this research are defined, designed, developed, and disseminated. The application's assessment instrument uses a Likert scale questionnaire distributed online. A sample was randomly selected from users of the e-wallet application, some teachers and students. The results of the digital wallet application product trial "DASIGU" to 173 students responded with 26 user experience questionnaire indicators resulted in a figure of 73.4% and belonged to the category of "Worth" use. It is hoped that through the development of this e-wallet application, it will be easier for the school community to transact support products in the form of services and goods produced by students.
Simulación del proceso de inventarios en una poscosecha de rosas de exportación bajo un enfoque de Business Process Management
Authors: Lozano Gil Rubén Alberto , Rodríguez-Ríos Claudia Yadira , Sepúlveda-Rojas Juan Pedro
Published: December 2022

Pocas empresas del sector floricultor colombiano hacen una gestión de sus inventarios, lo que redunda en quiebres de stock, tiempos muertos en operaciones clave de la poscosecha, incumplimientos de las órdenes de ventas y daños en la flor. Por esto, se plantea como objetivo general simular el proceso de inventarios manejado en la poscosecha de rosa (Rosa sp.), con el fin de encontrar oportunidades de mejora. Este trabajo de investigación fue un estudio de caso realizado en una empresa exportadora de ramos de rosa de Cundinamarca, ya que este departamento es el que tiene el mayor volumen de producción de flores tipo exportación a nivel nacional. Para ello, se seleccionó la poscosecha de rosa por los indicadores de producción bajos. De esta manera, se planteó una investigación descriptiva y exploratoria, y se hizo una modelación del proceso de inventarios, con ayuda de los jefes y un análisis de tiempos y de probabilidad de ocurrencia de las tareas involucradas. Posteriormente, se hizo la simulación con el tiempo de ciclo de proceso de inventario en Bizagi Modeler®, llevando a cabo un total de 36 réplicas. Esto dio como resultado un tiempo total de ciclo de proceso de inventarios de 9.684 minutos para la temporada de San Valentín, encontrando que el 44 % de las actividades pueden ser optimizadas. Finalmente, se concluye que, con la simulación del proceso de inventarios, se pueden encontrar actividades de no valor agregado, sirviendo de insumo en la elaboración de estrategias de mejora.
Identification of the parasites that cause children's cutaneous leishmaniasis and several types of immune response cells
Authors: Al-abodi Hiba Riyadh , Fadhel Wathah Esraa
Published: December 2022

Cutaneous leishmaniasis has received many epidemiological, diagnostic, therapeutic, quantitative and other studies. The current study aims to determine the type of leishmaniasis parasite that causes cutaneous leishmaniasis in children in the Al-Diwaniyah governorate in central Iraq to ​​assess the level of variations in globulins and immune cells in children with cutaneous leishmaniasis. Fifty-nine was a positive sample for the traditional laboratory examination of cutaneous leishmaniasis in children whose ages ranged between (8 months-10 and years). They were collected from the Maternity and Children Hospital from January 2020 to December 2021. The samples were subjected to molecular diagnostics to determine the type of leishmaniasis that causes the disease using Real-Time PCR. ELISA was approved to measure the levels of variation in the concentrations of IgG and IgM among the group of infected and healthy children. The results indicated that children's predominant type causing cutaneous leishmaniasis is L. major 52 samples (88.13%). The immunological study showed clear and statistically significant differences in the mean globulin concentrations for comparing the patient's L. major with the control group at a probability level (P≤0.05). The current study concluded that L. major is the dominant species responsible for cutaneous leishmaniasis.

Keywords: Catenous leishmaniasis, L. major, Real-Time PCR.
Impact of varying amounts of Moringa oleifera seed powder in the diet on a few aspects of common carp growth L. Cyprinus carpio
Authors: Zghair Al-Rawashi Jaber Bander , Salman Ali Hussain , Kassim Al-Gharawi Jassim
Published: December 2022

The current study was conducted in experimental cages in a mud pond, First Agricultural Research and Experiment Station, Agriculture College, Al-Muthanna University, to determine the effect of different levels of Moringa oleifera seed powder on the diets of common carp. A total of 75 common carp fish with an average weight of 65.08±0.42 g were used; it was randomly distributed to 5 treatments with three replicates (5 fish for each replicate). The fish that were fed on experimental diets was divided into five equal therapies in terms of protein percentages, different in the proportions of adding Moringa seed powder; the rate of seeds added to the treatments was 0, 0.5, 1, 1.5 and 2%, respectively, the fish were fed on the experimental diets at 5% of the live weight, divided into four meals a day. The results showed a significant superiority of T2 and T3 treatments compared with other therapies on growth parameters (final weight, weight gain, daily growth rate, specific and relative), and give the best feed conversion ratio, the highest food conversion and protein efficiency ratio. Indicates that adding Moringa seed powder to diets at rates of 0.5 and 1% led to fish growth promotion and increased utilization of feed intake.

Keywords: Moringa oleifera, growth parameters, common carp Cyprinus carpio L.
Closed Endotracheal Suction Systems for COVID-19: Rapid Review
Authors: Ramírez-Torres Carmen Amaia , Rivera-Sanz Félix , Sufrate-Sorzano Teresa , Pedraz-Marcos Azucena , Santolalla-Arnedo Ivan
Published: December 2022

Background

The increase in admissions to intensive care units (ICUs) in 2020 and the morbidity and mortality associated with SARS-CoV-2 infection pose a challenge to the analysis of evidence of health interventions carried out in ICUs. One of the most common interventions in patients infected with the virus and admitted to ICUs is endotracheal aspiration. Endotracheal suctioning has also been considered one of the most contaminating interventions.

Objective

This review aims to analyze the benefits and risks of endotracheal suctioning using closed suction systems (CSS) in COVID-19 patients.

Methods

A rapid review was carried out using the following databases: PubMed, MEDLINE, CINAHL, LILACS, the Cochrane Library, and IBECS. The data search included articles in English and Spanish, published between 2010 and 2020, concerning adult patients, and using the key words “endotracheal,” “suction,” and “closed system.”

Results

A total of 15 articles were included. The benefits and risks were divided into 3 categories: patient, care, and organization. Relating to the patient, we found differences in cardiorespiratory variables and changes in the ventilator, for example, improvement in patients with elevated positive and end-expiratory pressure due to maladaptation and alveolar collapse. Relating to care, we found a shorter suctioning time, by up to 1 minute. Relating to organization, we found fewer microorganisms on staff gloves. Other conflicting results between studies were related to ventilator-associated pneumonia, bacterial colonization, or mortality.

Conclusions

Aside from the need for quality research comparing open suction systems and CSS as used to treat COVID-19 patients, closed endotracheal suctioning has benefits in terms of shorter stay in the ICU and reduced environmental contamination, preventing ventilator disconnection from the patient, reducing the suctioning time—though it does produce the greatest number of mucosal occlusions—and preventing interpatient and patient-staff environmental contamination. New evidence in the context of the SARS-CoV-2 virus is required in order to compare results and establish new guidelines.
Patient Satisfaction With a Multisite, Multiregional Remote Patient Monitoring Program for Acute and Chronic Condition Management: Survey-Based Analysis (Preprint)
Authors: Haddad Tufia C , Maita Karla C , Inselman Jonathan W , Avila Francisco R , Torres-Guzman Ricardo A , Coffey Jordan D , Christopherson Laura A , Leuenberger Angela M , Bell Sarah J , Pahl Dominick F , Garcia John P , Manka Lukas , Forte Antonio J , Maniaci Michael J
Published: December 2022

BACKGROUND

Remote patient monitoring (RPM) is an option for continuously managing the care of patients in the comfort of their homes or locations outside hospitals and clinics. Patient engagement with RPM programs is essential for achieving successful outcomes and high quality of care. When relying on technology to facilitate monitoring and shifting disease management to the home environment, it is important to understand the patients’ experiences to enable quality improvement.

OBJECTIVE

This study aimed to describe patients’ experiences and overall satisfaction with an RPM program for acute and chronic conditions in a multisite, multiregional health care system.

METHODS

Between January 1, 2021, and August 31, 2022, a patient experience survey was delivered via email to all patients enrolled in the RPM program. The survey encompassed 19 questions across 4 categories regarding comfort, equipment, communication, and overall experience, as well as 2 open-ended questions. Descriptive analysis of the survey response data was performed using frequency distribution and percentages.

RESULTS

Surveys were sent to 8535 patients. The survey response rate was 37.16% (3172/8535) and the completion rate was 95.23% (3172/3331). Survey results indicated that 88.97% (2783/3128) of participants agreed or strongly agreed that the program helped them feel comfortable managing their health from home. Furthermore, 93.58% (2873/3070) were satisfied with the RPM program and ready to graduate when meeting the program goals. In addition, patient confidence in this model of care was confirmed by 92.76% (2846/3068) of the participants who would recommend RPM to people with similar conditions. There were no differences in ease of technology use according to age. Those with high school or less education were more likely to agree that the equipment and educational materials helped them feel more informed about their care plans than those with higher education levels.

CONCLUSIONS

This multisite, multiregional RPM program has become a reliable health care delivery model for the management of acute and chronic conditions outside hospitals and clinics. Program participants reported an excellent overall experience and a high level of satisfaction in managing their health from the comfort of their home environment.
Crowdsourcing Knowledge Production of COVID-19 Information on Japanese Wikipedia in the Face of Uncertainty: Empirical Analysis (Preprint)
Authors: Yang Kunhao , Tanaka Mikihito
Published: December 2022

BACKGROUND

A worldwide overabundance of information comprising misinformation, rumors, and propaganda concerning COVID-19 has been observed in addition to the pandemic. By addressing this data confusion, Wikipedia has become an important source of information.

OBJECTIVE

This study aimed to investigate how the editors of Wikipedia have handled COVID-19–related information. Specifically, it focused on 2 questions: What were the knowledge preferences of the editors who participated in producing COVID-19–related information? and How did editors with different knowledge preferences collaborate?

METHODS

This study used a large-scale data set, including >2 million edits in the histories of 1857 editors who edited 133 articles related to COVID-19 on Japanese Wikipedia. Machine learning methods, including graph neural network methods, Bayesian inference, and Granger causality analysis, were used to establish the editors’ topic proclivity and collaboration patterns.

RESULTS

Overall, 3 trends were observed. Two groups of editors were involved in the production of information on COVID-19. One group had a strong preference for sociopolitical topics (social-political group), and the other group strongly preferred scientific and medical topics (scientific-medical group). The social-political group played a central role (contributing 16,544,495/23,485,683, 70.04% of bits of content and 57,969/76,673, 75.61% of the references) in the information production part of the COVID-19 articles on Wikipedia, whereas the scientific-medical group played only a secondary role. The severity of the pandemic in Japan activated the editing behaviors of the social-political group, leading them to contribute more to COVID-19 information production on Wikipedia while simultaneously deactivating the editing behaviors of the scientific-medical group, resulting in their less contribution to COVID-19 information production on Wikipedia (Pearson correlation coefficient=0.231; P<.001).

CONCLUSIONS

The results of this study showed that lay experts (ie, Wikipedia editors) in the fields of science and medicine tended to remain silent when facing high scientific uncertainty related to the pandemic. Considering the high quality of the COVID-19–related articles on Japanese Wikipedia, this research also suggested that the sidelining of the science and medicine editors in discussions is not necessarily a problem. Instead, the social and political context of the issues with high scientific uncertainty is more important than the scientific discussions that support accuracy.
Compressive Strength Prediction for Industrial Waste-Based SCC Using Artificial Neural Network
Authors: Md Akram Hossain  , Islam G M Sadiqul , Amit Mallick
Published: December 2022

Concrete is the most used construction material in the world. Sustainable construction practice demands durable material. A particular type of concrete that flows and consolidates under its weight is proposed to reduce labor dependency during construction, called self-compacting concrete. It is installed without vibration due to its excellent deformability and flowability while remaining cohesive enough to be treated without difficulty. Evaluating its compressive strength is essential as it is used in important construction projects. An artificial neural network (ANN) is a predicting tool that can predict output in various sectors. This study evaluated the compressive strength of industrial waste such as fly ash and silica fume incorporated in self-compacting concrete at various ages. A non-linear relationship was used to develop the model relating mix composition and SCC compressive strength using an Artificial Neural Network (ANN). The experimental and expected outcomes were compared with the model prediction to evaluate the predictive capacity, generalize the generated model, and observe suitable matches. The developed ANN network can predict the desired output, i.e., compressive strength incorporating industrial waste. Furthermore, the influence of individual parameters viz. cement, silica fume, and fly ash, w/b were also evaluated using parametric analysis, which shows the sensitivity of various materials on the compressive strength of Self-compacting concrete. As a result, a higher correlation coefficient of 0.9835 with a smaller value of MAPE (0.0347) and RMSE (2.4503) is obtained. Finally, a process of creating tools for practical engineers and field users is proposed, which would be very handy and fast for predicting the strength of SCC.
Stock Market Prediction Using LSTM
Authors: Venikar Isha , Joshi Jaai , Jalnekar Harsh , Raut Shital
Published: December 2022

Abstract: This study proposes a model which will make use of an LSTM model for predicting stock prices. The stock prices will be predicted on the basis of past information. Stacked LSTM will be employed for the prediction because it utilizes the historic data, therefore, making the predictions more accurate since it is able to learn long term dependencies in data, which makes LSTM an ideal technique for stock market prediction due to its dynamic as well as complex nature. After training the model its accuracy will be checked by using the test data and then using the model the stock prices for the next 30 days will be forecasted using this model.
Smart Helmet
Authors: Raut Shital , Jadhav Mohinee , Kadam Ishita , Kadam Neha
Published: December 2022

Abstract: The usage of a smart helmet, a sort of protective headgear, increases the rider's level of safety when operating a motorcycle. This helmet's primary function is to keep the rider safe. Advanced features like fall detection, accident identification, location monitoring, and alcohol detection can be used to accomplish this. As a result, it doubles as a smart bike feature in addition to being a smart helmet. The ignition switch cannot turn ON without the helmet being worn, hence it is required. An RF Module can be used as a wireless link for transmission and reception. When a rider is intoxicated, the ignition locks itself and sends a message with his location to the registered phone number.In the event of an accident, it will send a message over GSM and provide its location using a GPS module. Fall detection is the project's standout feature; if the rider falls off the bike, a notice is sent.
English Language Teaching Educational Change: A Retrospective Analysis of Teacher Professional Development
Authors: Mai Le Xuan , Thao Le Thanh
Published: December 2022

The importance of English has demanded the introduction of English language teaching (ELT) educational reforms (ERs) in the Vietnamese context. However, the results of these reforms did not satisfy Vietnamese educators; as a result, many studies have explored the related issues, but almost none of them emphasized English as a foreign language (EFL) teachers’ perceptions of the necessities of the reforms. Accordingly, this current study was conducted to fill in the aforementioned gap. Driven by that emphasis, this qualitative study used semi-structured interviews as a data-collecting instrument. Regarding the studied sampling, six EFL high school teachers from Southwest Vietnam were recruited as the interviewees. According to the findings of the present study, teachers in Vietnam strongly perceived the need for ELT ERs. Besides, the reforms were fundamental to help catch up with the era of globalization. At the conclusion of the paper, some discussions focusing primarily on teacher training issues and educational implications, as well as suggestions for future research, were presented.