bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical Analysis of 44 Cases of Atypical Polypoid Adenomyoma of the Uterus
Authors: Wang Xin , Guo Yinshu
Published: January 2022

Background: Atypical polypoid adenomyoma (APA) is a rare intrauterine polypoid lesion that occurs predominantly in premenopausal women. Although, it is considered as a benign lesion and treated conservatively previously, more and more cases show that APA has a high rate of recurrence or residual, and is found to precede the development of carcinoma. The clinical management of APA remains to be established. The aim of this study was to analyse the clinicopathological features of APA and discuss its diagnosis and prognosis.Methods: Forty-four patients with APA were admitted to Beijing Obstetrics and Gynecology Hospital from 2005-2019, and their clinical and histopathologic features were evaluated. B-ultrasound was performed, and all patients (n=44) underwent hysteroscopy. Endometrium excision was performed by means of the “Four-step diagnosis and treatment” method. Hysteroscopic transcervical resection (TCR) was performed in 5 cases with APA-H and 11 with APA-L. Except for one patient who underwent transcervical endometrial resection, all patients underwent hysterectomy and salpingectomy or salpingo-oophorectomy. Data from a median follow-up of 42 months (ranging from 3 to 174 months) were available for these patients.Results: Pathological diagnoses were made according to the degree of abnormality of APA surface glands, resulting in APA-L in 36 cases and APA-H in 8 cases. Among these cases, 28 (25 APA-L and 3 APA-H) were treated conservatively. “Four-step diagnosis and treatment” method performed a excellent effect for APA therapy. During the follow-up no evidence of recurrence was found.Conclusions: For cases with intracavitary lesions > 1 cm, hysteroscopic “four-step diagnosis and treatment” and pathological diagnosis are the basis of clinical treatment. More than 30% of APA surface glands have complex structures, characterized by branching and budding, or other high-risk factors, such as endometrial hyperplasia, which are indications for hysterectomy. For patients with the desire to become pregnant or for uterine preservation, hysteroscopy with complete excision of the lesions should be the preferred treatment method. The patients should be treated individually, followed up closely, and followed up by regular hysteroscopy and endometrial biopsy.
Mutational screening of the TPO and DUOX2 genes in Argentinian children with congenital hypothyroidism due to thyroid dyshormonogenesis.
Authors: Molina Maricel F. , Papendieck Patricia , Sobrero Gabriela , Balbi Viviana A. , Belforte Fiorella S. , Martínez Elena Bueno , Adrover Ezequiela , Olcese María C. , Chiesa Ana Elena , Miras Mirta Beatriz , González Verónica G. , Pio Mauricio Gomes , González-Sarmiento Rogelio , Targovnik Héctor Manuel , Rivolta Carina Marcela
Published: January 2022

Purpose

Primary congenital hypothyroidism (CH) is the most common endocrine disease in children and one of the preventable causes of both cognitive and motor deficits. We present a genetic and bioinformatics investigation of rational clinical design in 16 Argentine patients suspected of CH due to thyroid dyshormonogenesis (TDH).
Methods

Next-Generation Sequencing approach was used to identify variants in Thyroid Peroxidase (TPO) and Dual Oxidase 2 (DUOX2) genes. A custom panel targeting 7 genes associated with TDH [(TPO, Iodothyrosine Deiodinase I (IYD), Solute Carrier Family 26 Member 4 (SLC26A4), Thyroglobulin (TG), (DUOX2), Dual Oxidase Maturation Factor 2 (DUOXA2), Solute Carrier Family 5 Member 5 (SLC5A5)] and 4 associated with thyroid dysembryogenesis [PAX8, FOXE1, NKX2-1, Thyroid Stimulating Hormone Receptor (TSHR)] has been designed. Additionally, bioinformatic analysis and structural modeling were carried out to predict the disease-causing potential variants.
Results

Five novel variants have been identified, two in TPO: c.2749-2A>C and c.2752_2753delAG, [p.Ser918Cysfs*62] and three variants in DUOX2 gene: c.425C>G [p.Pro142Arg]; c.790delC [p.Leu264Cysfs*57] and c.2695delC [p.Gln899Serfs*21]. Seventeen identified TPO, DUOX2 and IYD variants were previously described. We identified potentially pahogenic bi-allelic variants in TPO and DUOX2 in 8 and 2 patients, respectively. We also detected a potentially pathogenic mono-allelic variant in TPO and DUOX2 in 4 and 1 patients respectively. Only two patients were heterozygous for digenic variants in TPO/IYD and in TPO/DUOX2 genes.
Conclusions

22 variants have been identified associated with TDH. All described novel mutations occur in domains important for protein structure and function, predicting the TDH phenotype.
Outer trench slope extension to frontal wedge compression in a subducting plate
Authors: CHANG Emmy Tsui-Yu , Mozziconacci Laetitia
Published: January 2022

Faulting in subducting plates is a critical process that changes the mechanical properties the subducting lithosphere and serves as a carrier of surface materials into mantle wedges. Two intraplate earthquake sequences located in the northern Manila subduction system were investigated in this study, which revealed distinct fault planes but a contrasting seismogeny over the northern Manila Trench. The seismic sequences analyzed in this study were of small-to-moderate events. The events were separately acquired by two ocean-bottom seismometer networks deployed on the frontal accretionary wedge in 2005 and the outer trench slope in 2006. The retrieved seismicity in the frontal wedge (in 2005) mainly included the overpressured sequence, whereas that in the approaching plate (in 2006) was aftershocks of an extensional faulting sequence. The obtained seismic velocity models and Vp/Vs ratios revealed that the overpressure was likely caused by dehydration within the shallow subduction zone. By using the near-field waveform inversion algorithm, we determined focal mechanism solutions for a few relatively large earthquakes. Data from global seismic observations were also used to conclude that stress transfer may be responsible for the seismic activity in the study area in 2005–2006. In late 2005, the plate interface in the frontal wedge area was unlocked by overpressure effect with the thrusting-dominant sequence. This event changed the stress regime across the Manila Trench and triggered the normal fault extension at the outer trench slope in mid-2006. However, the hybrid focal solution indicating reverse and strike-slip mechanisms provided in this study revealed that the plate interface had become locked again in late 2006.
Tuning of Composition and Morphology of LiFePO4 Cathode for Applications in All Solid-State Lithium Metal Batteries
Authors: Harimohan Erabhoina , Thelakkat Mukundan
Published: January 2022

All solid-state rechargeable lithium metal batteries (SS-LMBs) are gaining more and more importance because of their higher safety and higher energy densities in comparison to their liquid-based counterparts. In spite of this potential, their low discharge capacities and poor rate performances limit them to be used as state-of-the-art SS-LMBs. This arise due to the low intrinsic ionic and electronic transport pathways within the solid components in the cathode during the fast charge/discharge processes. Therefore, it is necessary to have a cathode with good electron conducting channels to increase the active material utilization without blocking the movement of lithium ions. Since SS-LMBs require a different morphology and composition of the cathode, we selected LiFePO4 (LFP) as a prototype and, we have systematically studied the influence of the cathode composition by varying the contents of active material LFP, conductive additives (super C65 conductive carbon black and conductive graphite), ion conducting components (PEO and LiTFSI) in order to elucidate the best ion as well as electron conduction morphology in the cathode. In addition, a comparative study on different cathode slurry preparation methods was made, wherein ball milling was found to reduce the particle size and increase the homogeneity of LFP which further aids fast Li ion transport throughout the electrode. The SEM analysis of the resulting calendered electrode shows the formation of non-porous and crack-free structures with the presence of conductive graphite throughout the electrode. As a result, the optimum LFP cathode composition with solid polymer nanocomposite electrolyte (SPNE) delivered higher initial discharge capacities of 114 mAh g-1 at 0.2C rate at 30 ᴼC and 141 mAh g-1 at 1C rate at 70 ᴼC. When the current rate was increased to 2C, the electrode still delivered high discharge capacity of 82 mAh g-1 even after 500 cycle, which indicates that the optimum cathode formulation is one of the important parameters in building high rate and long cycle performing SS-LMBs.
Pulmonary Hypertension at Admission predicts ICU Mortality in Elderly Critically ill with Severe COVID-19 Pneumonia: retrospective cohort study
Authors: Kurnik Marko , Božič Helena , Vindišar Anže , Kolar Petra , Podbregar Matej
Published: January 2022

BackgroundPoint-of-care ultrasound (POCUS) is a useful diagnostic tool for non-invasive assessment of critically ill patients. Mortality of elderly patients with COVID-19 pneumonia is high and there is still scarcity of definitive predictors. Aim of our study was to assess the prediction value of combined lung and heart POCUS data on mortality of elderly critically ill patients with severe COVID-19 pneumonia.MethodsThis was a retrospective observational study. Data of patients older than 70 years, with severe COVID-19 pneumonia admitted to 25-bed mixed, level 3, intensive care unit (ICU) was analyzed retrospectively. POCUS was performed at admission; our parameters of interest were pulmonary artery systolic pressure (PASP) and presence of diffuse B-line pattern (B-pattern) on lung ultrasound.ResultsBetween March 2020 and February 2021, 117 patients aged 70 years or more (average age 77±5 years) were included. Average length of ICU stay was 10.7±8.9 days. High-flow oxygenation, non-invasive ventilation and invasive mechanical ventilation were at some point used to support 36/117 (31%), 39/117 (33%) and 75/117 (64%) patients respectively. ICU mortality was 50.9%. ICU stay was shorter in survivors (8.8±8.3 vs 12.6±9.3 days, p=0.02). PASP was lower in ICU survivors (32.5±9.8 vs. 40.4±14.3 mmHg, p=0.024). B-pattern was more often detected in non-survivals (35/59 (59%) vs. 19/58 (33%), p=0.005). PASP and B-pattern at admission were both univariate predictors of mortality. PASP at admission was an independent predictor of ICU (OR 1.0683, 95%CI: 1.0108-1.1291, p=0.02) and hospital (OR 1.0813, 95%CI 1.0125-1.1548, p=0.02) mortality. Ventilator associated pneumonia (VAP) was a strong predictor of ICU and hospital mortality.ConclusionsPASP at admission is an independent predictor of ICU and hospital mortality of elderly patients with severe COVID-19 pneumonia. During ICU stay development of VAP was a strong predictor of ICU and hospital mortality.
A Practical Approach to choosing Formulae for Economic Index Numbers
Authors: Wood John
Published: January 2022

Traditional axiomatic, economic and stochastic approaches to choosing a formula for economic index numbers are based on theoretical considerations, with little regard to whether they reflect the actual circumstances affecting the markets to which they relate. This paper presents an approach to index number formulation based on how markets operate and presents a general, parameter-based formula for price and quantity indices. Two variants of this general formula cater for the “substitution effect” in different ways and one of these variants provides a practical expression for an economic-theoretic index based on purchasers' revealed preferences. Another variant applies this approach to short-term inflation indices. A final variant provides a straightforward means of estimating purchasing power parities for spatial indices. The analysis also emphasises the importance in National Accounts of using coherent price and quantity indices, whose products generate the corresponding value indices.
Botulinum toxin as adjuvant therapy for hypertonic dysfunction in a neuro-rehabilitation cohort
Authors: Hora Thiago Falcão , Guerra Agostinho de Alencar , Kuhne Gerson Otmar , Alvarenga Vinícius de Sousa , Oliveira Sabrina Fonseca , Fortes Caroline Echevarria , Montanaro Vinicius Viana
Published: January 2022

Purpose: Botulinum toxin (BTX) is a neurotoxin produced by the bacterium Clostridium botulinum, in recent decades, BTX has become an important adjunct treatment to neurological or rehabilitative strategies.We aimed to describe the clinical aspects of patients admitted to a rehabilitation hospital who were treated with BTX for spasticity and dystonia. Methods: This was a historical cohort; data was collected from the electronic charts of all outpatients treated with BTX between 2014 and 2016 in the spasticity and movement disorders service of a quaternary, open access, rehabilitation hospital. The inclusion criteria were limb spasticity due to traumatic brain injury (TBI), and stroke; limb tremor; cervical dystonia; and generalized limb dystonia from any cause in addition to pain that limits rehabilitation. We used relatively lower doses than those generally published in the literature. Therapeutic response was determined by the Goal attainment scale (GAS), pain (graded by visual analogue scale ), independence for daily living activities, target joint range of motion (pre- and post-application), and gait analysis (only for walkers patients). Results: A total of 63 patients were enrolled in this study with a mean follow-up of 2 years. There was significant improvement in joint restriction ) with 66.7% of patients reporting improvement in the GAS scale, best improvement occurred with ortheses and limb adjustments. Conclusions: Most patients have improved functionality on the GAS scale after treatment with BTX, which is used as an adjunct therapy in subjects already in rehabilitation programs. The main rehabilitation objectives with the GAS scale were achieved in most patients.
A parent-led intervention to reduce anxiety in autistic children with a severe to profound intellectual disability: protocol for the LADDERS pilot feasibility trial
Authors: Waite Jane , Tarver Joanne , Pearson Effie , Hughes Jessica , Edwards Georgina , Bird Megan , Greenhill Courtney
Published: January 2022

Background
There is a need for evidence-based approaches to reduce anxiety experienced by autistic children with severe to profound intellectual disability (ID). Avoidance of anxiety triggers, as a response to pronounced anxiety, occurs irrespective of age, background and neurodiversity. When avoidance is unhelpful, evidence-based anxiety reduction approaches aim to reduce it gradually (graded exposure), subsequently reducing anxiety. Combining graded exposure with emotional regulation techniques may be effective and acceptable for autistic children with severe to profound ID, if sensitive to needs and characteristics of autistic children. We have developed a 16-week, parent-led intervention (LADDERS) to reduce anxiety in this population of autistic children. LADDERS consists of psychoeducation, graded exposure-based tasks, and skills building, delivered utilising a person-centred approach. This study aims to assess whether LADDERS 1) reduces anxiety and 2) whether autistic children and parents find it acceptable and feasible.
Method
A single-site, multiple baseline, single case experimental study will be conducted. Participants will be parents of autistic children aged between 4-15 years. A minimum of 8 participants will be recruited through a research participant database, the Autistica Discover Network and social media. Once eligibility is confirmed, participants will be assessed at baseline, during the intervention and at a 2-month follow-up (week 24). The primary outcome measure will be a daily diary that assesses child anxiety.
Discussion
The study will provide preliminary evidence of whether LADDERS reduces anxiety in autistic children with severe to profound ID. Qualitative data from parents and child engagement will provide data on acceptability and feasibility.
Prognostic Factors of Disease-Free Survival in Postoperative Patients with Hepatocellular Carcinoma
Authors: Luo Panquan , Zhang Lixiang , Ding Bocheng , Chen Lei , Zhou Baichuan , Wei Zhijian , Xu Aman
Published: January 2022

Background
Hepatocellular carcinoma (HCC) is a primary malignancy of the hepatocyte with high risk of invasion, metastasis and poor prognosis, which leads to a high mortality rate in recent years. This study aims to investigate the independent prognosis factors of DFS(disease free survival) in primary hepatocellular carcinoma patients after radical hepatectomy and construct a nomogram prediction model.
Methods
This study retrospectively analyzed 358 patients admitted to the 1st Affiliated Hospital of Anhui Medical College from December 2009 to December 2014. Categorical variables were analyzed by chi-square test. The survival curve was plotted by kaplan-meier method and tested by log-rank method. Univariate and multivariate cox regression analyses were performed to determine the prognostic factors. A nomogram was constructed to predict the 3-year and 5-year DFS of HCC patients based on these factors. The performance of the nomogram was assessed with the C-indexes and calibration plot diagrams.
Results
Among the 344 patients with HCC, 298 cases (86.63%) are young patients (<70years), and 46 cases (13.37%) were elderly patients (≥70 years). The univariate and multivariate analyses showed that age, TNM stage, history of hepatitis B were the independent factors for DFS. The Kaplan-Meier curves indicated that elderly patients, TNM I-II stage and no history of hepatitis B had longer DFS. The C-index of the nomogram was 0.604(95%CI:0.561-0.647), and the Calibration curve showed that the actual DFS curve of the nomogram fits the predicted DFS curve.
Conclusions
Our findings suggested that age, TNM stage, history of hepatitis B were independent factors for predicting DFS of HCC patients. Patients older than 70 years had a better prognosis than young patients. Patients with early TNM stage and no history of hepatitis B had longer DFS. We constructed and validated a new nomogram for predicting DFS in HCC patients.
PENGARUH HARGA, KEMASAN, KUALITAS PRODUK, BRAND IMAGE DAN WORD OF MOUTH TERHADAP MINAT BELI MAHASISWA PADA PRODUK “LE MINERALE”
Authors: Rafikasari Elok Fitriani , Fauzy Nadia Eva Nur
Published: January 2022

Perkembangan industri Air Minum Dalam Kemasan (AMDK) di Indonesia berkembang pesat. Hal tersebut mengakibatkan adanya persaingan yang ketat antar perusahaan AMDK untuk menarik perhatian konsumen. Salah satu konsumen AMDK adalah mahasiswa. Mahasiswa juga memiliki pertimbangan tertentu sebelum membeli air minum dalam kemasan. Penelitian ini bertujuan untuk mengetahui pengaruh harga, kemasan, kualitas produk, brand image dan word of mouth terhadap minat beli produk AMDK merek Le Minerale secara parsial, simultan menggunakan analisis regresi linier berganda. Sumber data yang digunakan adalah data primer dengan menyebarkan kuisioner. Hasil penelitian menunjukkan bahwa secara parsial, hanya variabel word of mouth yang berpengaruh terhadap minat beli produk AMDK merek Le Minerale. Harga, kemasan, kualitas produk, brand image dan word of mouth secara simultan berpengaruh terhadap minat beli produk AMDK merek Le Minerale dengan total pengaruh sebesar 57,5%.
ETIKA BERBHINEKA: BELAJAR MEMBANGUN KESADARAN MULTIKULTURALISME DARI NABI DAN PARA WALI
Authors: Khasani Fahim
Published: January 2022

The problem of multiculturalism is the problem of our civilization. Indonesia with all its differences and cultural richness is one of the countries that has the potential for horizontal conflict. The efforts to unite and maintain unity must be three steps ahead of the threat of disintegration. The disruption era that is completely unpredictable and hoaxes and hate speech on social media makes it difficult to maintain security and maintain a conducive, harmonious and peaceful situation. Hostile with the others is not tradition of Nusantara people. Our tradition is a dialogue as well as strengthening the harmony of every difference. In this case, the Prophet Muhammad and the Walisongo have set a good example of living side by side with different communities. This article will discuss the strategies of the Walisongo in dialogue between religion and culture, as well as the strategy of the Prophet Mohammed in managing differences and building harmony in a pluralistic society. The results of the study conclude that to build a nation that is baldatun thayyibah wa Rabbun ghafur, it is necessary to have a society that is not only saleh ritual, but also saleh sosial and saleh kultural.
Interactions in ternary bismuth-containing molybdate systems M2MoO4-Bi2(MoO4)3-Zr(MoO4)2 in the subsolidus region
Authors: Bazarova J. G. , Logvinova A. V. , Bazarov B. G.
Published: January 2022

A fundamental problem in materials science consists in establishing a relationship between the chemical composition, structure, and properties of materials. This issue can be solved through the study of multicomponent systems and the directed synthesis of promising compounds. Of practical interest here are active dielectrics that are based on complex oxide compounds, specifically molybdates. Among complex molybdates and tungstates, ternary caged molybdates of the following structural types are of greatest importance: nasicon, perovskite, langbeinite, etc. Due to their widely varying elemental and quantitative compositions, such molybdates are convenient models for structural and chemical design, as well as the establishment of “composition–structure– properties” genetic relationships. Bismuth-containing complex molybdate systems exhibit the formation of phases having ferro-piezoelectric, ionic, and other properties. In this work, the Rb2MoO4–Bi2(MoO4)3–Zr(MoO4)2 ter nary salt system was studied for the first time using the method of intersecting sections in the subsolidus region (450–650 ℃). To this end, quasibinary sections were identified; triangulation was performed. Ternary molybdates Rb5BiZr(MoO4)6 and Rb2BiZr2(MoO4)6,5 were formed in the system using a ceramic technology. These compounds are isostructural to the previously obtained REE molybdates (M5LnZr(MoO4)6) but contain trivalent bismuth instead of rare earth elements. The structure of Rb5BiZr(MoO4)6 was adjusted via the Rietveld refinement technique using the TOPAS 4.2 software package. The ternary molybdate crystallizes in a trigonal system, with the following unit cell parameters of the R`3c space group: a = 10.7756(2) and c = 39.0464(7) Å. According to the studies of thermal properties exhibited by M5BiZr(MoO4)6, these ternary molybdates undergo the first-order phase transition in the temperature range of 450–600 ºC. The IR and Raman spectra of M5BiZr(MoO4)6 reveal the crystallization of ternary molybdates in the R`3c space group. The conducted comparative characterization of M2MoO4–Bi2(MoO4)3–Zr(MoO4)2 phase diagrams suggests that the phase equilibria of these systems depend on the nature of molybdates of monovalent elements.
Acinetobacter Baumannii – Virulence Factors and Epidemiology of Infections
Authors: Marszalik Anna , Sidor Karolina , Kraśnicka Agnieszka , Wróblewska Marta , Skirecki Tomasz , Jagielski Tomasz , Stachowiak Radosław
Published: January 2022

Acinetobacter baumannii is a Gram-negative saprophytic rod inhabiting both moist niches and dry surfaces. The wide spread of the microbe in the environment by means of minimal nutritional requirements and exceptional survival capabilities give the opportunities to occupy hospital niches, and thus to create threats for hospitalized patients. This bacterium may be a part of the human microbiota as an opportunistic pathogen which upon the host’s weakening, causes less or more serious diseases. A. baumannii is an etiological factor of ventilator-associated pneumonia, which is especially dangerous for patients in intensive care units (in Poland every fifth patient suffers from such infection). Due to the increasing multidrug resistance of A. baumannii, this bacterium belongs to the group of priority pathogens. Fighting such dangerous bacteria is difficult due to their natural resistance as well as acquired resistance mechanisms in response to environmental threats. The unique ability of A. baumannii to cause diseases and acquire resistance to numerous antibiotics, make it necessary to control and prevent these infections.
Rana Oparzeniowa – Procesy Jej Rozwoju Oraz Wybrane Czynniki Etiologiczne Zakażenia
Authors: Korzekwa Kamila , Sobolewski Kamil , Sobolewski Bartłomiej
Published: January 2022

Streszczenie

Chociaż tematyka oparzeń wydaje się być stosunkowo dobrze opracowana w piśmiennictwie, nadal istnieje potrzeba określenia związku patomechanizmu urazów termicznych z kluczową kwestią zakażeń w ich obrębie. Niezmiernie istotna w przypadku zakażeń ran oparzeniowych jest diagnostyka mikrobiologiczna. Prawidłowe pobranie materiału klinicznego i wykonanie badań mikrobiologicznych pozwala na ustalenie czynnika etiologicznego zakażenia i dobranie antybiotykoterapii celowanej. Jest to szczególnie istotne w dobie narastania oporności drobnoustrojów na antybiotyki i częstego izolowania szczepów wieloantybiotykoopornych. Oparzenie bowiem, zwłaszcza rozległe, stanowi unikalne środowisko, które – wraz z nieprzemyślaną, bądź niecelowaną terapią – determinuje u drobnoustrojów nabywanie oporności na antybiotyki. Fizjologiczna obrona organizmu przed urazem prowadzi do sytuacji, kiedy w ranie oparzeniowej środki przeciwdrobnoustrojowe mogą nie osiągać MIC/MBC, co drastycznie zmniejsza szanse powodzenia terapeutycznego.
Systematyka i Analizy Genomiczne Bakterii z Rodzaju Azotobacter
Authors: Kozieł Monika , Gałązka Anna
Published: January 2022

Streszczenie

Bakterie z rodzaju Azotobacter są przedmiotem wielu badań prowadzonych zarówno w Polsce jak i za granicą. Zainteresowanie tą grupą bakterii w dużej mierze związane jest z ich właściwościami, które mogą być wykorzystywane w rolnictwie. Najnowsze badania opierają się na zaawansowanych metodach molekularnych i bazują na poznanej sekwencji genomów dwóch gatunków: Azotobacter vinelandii i Azotobacter chroococcum. W 2009 roku Setubal i in. opublikowali pełną sekwencję genomu Azotobacter vinelandii DJ, z kolei pełną sekwencję genomu Azotobacter chroococcum 8003 opublikowali Robson i in. w pracy z 2015 roku. Obie bakterie mają pojedynczy, kolisty chromosom o wielkości odpowiednio 5,365,318 pz. i 5,192,291 pz. Poznanie i porównanie sekwencji genomów Azotobacter vinelandii DJ i Azotobacter chroococcum 8003 pozwoliło odpowiedzieć na wiele pytań dotyczących ewolucji, różnorodności i miejsca tych bakterii w środowisku. Zsekwencjonowanie większej liczby genomów innych szczepów A. chroococcum i A. vinelandii przyniosłoby wiele korzyści i pozwoliłoby uporządkować dotychczasową wiedzę na ich temat.
Development of English Teaching Module for Electrical Engineering Study Program
Authors: Atiqah Nurul Asri  , Aly Imron  , Satrio Binusa Suryadi
Published: January 2022

The proper teaching materials determine successful teaching-learning. Teaching materials are required to adapt to the current situation of the institution, curriculum, and learners. The new curriculum adopted by the Electrical Engineering Study Program required the updated version since English courses had been replaced by the first and last semester of both the D3 and D4 programs. Developing the new teaching materials for the study program aimed to provide relevant issues and teaching strategies that could boost students' motivation in the classroom. Thus, the developed teaching materials were to propose the teaching and learning that fit the learner's needs. The research objective was to develop new teaching modules for the Electrical Engineering Study Program that were much more interactive, effective, and efficient for the learners to study English within the Electrical Engineering context. This research applied Research and Development (R&D) model adopted from Borg and Gall comprising six stages, namely: (1) needs analysis, (2) designing the product, (3) proposing the product, (4) evaluating the product, (5) testing and (6) disseminating the product. As a result, the new teaching module was redesigned to provide English teaching and learning effectively and efficiently that could be easily understood and helpful for the student to achieve the learning outcomes as expected.
Improving Students’ Writing Skill through Marking System Feedback
Authors: Hoeriyah
Published: January 2022

Writing is one of the four language skills that the learners should master. The 2013 curriculum also says that one of the English language competencies specified in high school level is that students must be able to compose short written texts using coherent text structures and linguistic elements fluently and accurately. In line with that this study aims to find out whether the marking system feedback can improve students' writing skill. This is a two-cycle classroom action research at SMA Negeri 1 Sewon. The subjects were 26 tenth grade students of class X MIPA 1. The data were collected from observation, written documents, writing scores, and questionnaire. The study results showed that by applying the marking system feedback, students' writing skills improved. The mean scores of the students' writing ability in the pre-cycle was 63.65 at the poor category, the first cycle was 73.65 at the fair category, and the second cycle was 81.35 at the good category. In addition, students tend to give positive responses to the implementation of the marking system feedback. As many as 88.46% think that the feedback is useful in writing activities and can help them in correcting their mistakes, 73.08% think that the technique makes them understand the grammar better, and 80.77% say this technique leads them to be more careful in their writing and also motivates them to improve their composition.
Delocalization transition in low energy excitation modes of vector spin glasses
Authors: Franz Silvio , Nicoletti Flavio , Parisi Giorgio , Ricci-Tersenghi Federico
Published: January 2022

We study the energy minima of the fully-connected
mm-components
vector spin glass model at zero temperature in an external magnetic
field for m\ge 3m≥3.
The model has a zero temperature transition from a paramagnetic phase at
high field to a spin glass phase at low field. We study the eigenvalues
and eigenvectors of the Hessian in the minima of the Hamiltonian. The
spectrum is gapless both in the paramagnetic and in the spin glass
phase, with a pseudo-gap behaving as \lambda^{m-1}λm−1
in the paramagnetic phase and as \sqrt{\lambda}λ
at criticality and in the spin glass phase. Despite the long-range nature of the model, the
eigenstates close to the edge of the spectrum display quasi-localization
properties. We show that the paramagnetic to spin glass transition
corresponds to delocalization of the edge eigenvectors. We solve the
model by the cavity method in the thermodynamic limit. We also perform
numerical minimization of the Hamiltonian for
N\le 2048N≤2048
and compute the spectral properties, that show very strong corrections
to the asymptotic scaling approaching the critical point.
SOCIO-DEMOGRAPHIC PROFILE AND FACTORS RELATED TO BLOOD DONOR RETENTION: THE CASE OF THE OMAR BONGO ONDIMBA REGIONAL HOSPITAL OF MAKOKOU (CHROBOM), IN THE NORTH-EAST, GABON
Authors:   Medical Analysis Laboratory of the Centre Hospitalier Regional Omar Bongo Ondimba (CHROBO) Makokou, Gabon., Obiandong Eyivono Armel ,   Laboratory of Molecular and Cellular Biology (LABMC) Masuku University of Science and Technology (USTM), Franceville, Gabon., Ndong Mba Thiery ,   Laboratory of Molecular and Cellular Biology (LABMC) Masuku University of Science and Technology (USTM), Franceville, Gabon.,   Biochemistry Research Laboratory (LAREBIO), University of Science and Technology of Masuku (USTM) Franceville, Gabon., Eymard Ondo Nang Junior ,   Medical Analysis Laboratory of the Centre Hospitalier Regional Omar Bongo Ondimba (CHROBO) Makokou, Gabon., Mickala Patrick ,   Laboratory of Molecular and Cellular Biology (LABMC) Masuku University of Science and Technology (USTM), Franceville, Gabon.,   Laboratory of Animal Physiology, University of Science and Technology of Masuku (USTM), Franceville, Gabon.
Published: January 2022

Objective: In order to implement a targeted strategy during communication campaigns, this study defines the socio-demographic profile of blood donors and the factors that can promote their loyalty to blood donation in the northeast region of Gabon. Material And Methods: This descriptive cross-sectional study was conducted from March to September 2021 and enrolled 252 blood donors with a mean age of 29.6 Â± 7 years, ranging from 19 to 51 years. After an interview based on a pre-established pre-donation questionnaire, each donor deemed suitable underwent a sampling that was then analyzed through an infectious workup and a blood count (CBC). Data collected from the questionnaire were entered into a spreadsheet in Excel 2016 and processed with R software in its R Commander interface and results were considered significant if p < 0.05. Results: Using Pearsons Chi-square test of independence, this study indicated an association between blood donation and many sociodemographic parameters. Thus, being a former donor was statistically associated with firstly male gender, secondly being a parent, thirdly having a job, and finally being 30 years or older. Multinomial logistic regression analysis was able to establish that: Being a parent, Having a job and Being male, increased the probability of being a faithful blood donor. Conclusion:. The profile of the blood donor at the Omar Bongo Ondimba Regional Hospital of Makokou corresponds to A man of about 30 years old, single, unemployed, with at least one child coming for a family type donation and the factors of loyalty to blood donation are the male sex, the status of worker and that of being a family member.
STUDY ON ICHTHYOFAUNAL DIVERSITY IN RELATION TO PHYSICO-CHEMICAL PARAMETERS OF MANAKONDUR FRESH WATER LAKE OF KARIMNAGAR DISTRICT, TELANGANA STATE, INDIA
Authors:   Department of Zoology, Kakatiya University, Warangal-506 009, Telangana State, India., Rajani V.
Published: January 2022

Freshwater bodies are one of the most common and stable habitats of biosphere. The freshwater habitats have their own physico-chemical and biological characters which are subjected to modify by local conditions and physiographic features. The water quality parameters have a great influence on the growth and other factors of aquatic organisms. Therefore, the lentic water body gives a good source for fisheries. The present investigation deals with limnological and physico-chemical parameters and their influence on Ichthyofauna abundance in Manakondur fresh water Lake at Karimnagar District, Telangana State. The study was carried out for a period of one year i.e., from June, 2020 to May, 2021.The investigation was focused on the determination of hydro-chemical parameters such as Water temperature(19.0-31.0ÂºC),Transparency(18.50-44.30cm),TDS(200-350mg/l),PH(7.5-8.3),DO(5.2-12.0mg/l),Co2 (3.0-9.2mg/l),TH(110-210mg/l),TA(165-300mg/l),CL(35.00-50.20mg/l),Po4 (0.02-0.16mg/l),No3 (0.02-0.14mg/l) and BOD(2.5-7.0mg/l).The study was made to recorded fish fauna available. Total 33 species of fishes were collected and identified during the study period which belongs to 6 orders, 12 families and 18 genera. The order Cypriniformes was dominant with 15 species, followed by Siluriformes (8 species), Osteoglosiformes(2 species), Perciformes(4 species), Channiformes(3 species), Perciformes(4 species) and Antherniformes(1 species) were identified. Order wise percentage composition is Cypriniformes (17%), Siluroformes (34%), (Osteoglossiformes(8%), Perciformes (25%), Channiformes (8%), Anthrniformes (8%) In the light of recent literature, the data has been discussed and it is concluded that limnological and physico-chemical parameters in this reservoir are most comply with suitability of human consumption and favourable for fishery. In the light of recent literature, the data has been discussed and it is concluded that limnological and physico-chemical parameters in this reservoir are most comply with suitability of human consumption and favourable for fishery.
Síelés, avagy hogy készítsük fel izmainkat a síszezonra?
Authors: Biróné Ilics Katalin , Nagyváradi Katalin
Published: January 2022

Síszezon előtt sokaktól halljuk, hogy készülnek a szezonra. Ez alatt többnyire a síeléshez szükséges eszközök (ruházat és sífelszerelés) megvásárlását, javíttatását értik. Ahogy a felszerelések is „pihentek” az előző szezon óta, úgy a síeléshez szükséges izomzatunk is sok esetben inaktívan töltötte ezt az időszakot. A sérülések megelőzése miatt a síelés során használt úgynevezett „sífunkciós” izomzatunkat is érdemes „felébreszteni”, aktiválni az idény előtt. Írásunkban a síelés során leginkább igénybe vet izmok felkészítésére közlünk szárazföldi gyakorlatokat. A feladatok összeállítása az alapvető mozgásminták használatával történt. A gyakorlatok kiválasztása során azokra az izmokra fókuszáltunk, melyek elsődleges szerepet játszanak a síelés közbeni folyamatosan változó körülményekhez történő adaptációban, a stabilitás, illetve a mobilitás közt egyensúly megteremtésében.
Pasión y actos delictivos en las barras bravas de fútbol
Authors: Truyenque Raysa , Muñoz Felipa
Published: January 2022

El presente artículo de revisión tiene como título “Pasión y actos delictivos en las barras bravas de fútbol”. Objetivo: Comparar las propuestas sobre los actos delictivos que originan violencia en las barras bravas de fútbol. Método: Estudios descriptivos, de revisión de artículos de científicos en revistas indexadas publicadas en diferentes bases de datos entre los años 2014-2021. Las investigaciones analizadas desarrollaron estudios descriptivos, correlacionales, inductivos. Resultados: Se identificaron 28 artículos relacionados al tema de los cuales se seleccionaron 10. La revisión ha evidenciado que el problema de las barras bravas nace a partir de las rivalidades que presentan los grupos por defender al club de sus amores, siendo un problema social que está relacionado con el fenómeno de las pandillas conformadas por aproximado de 15 y 100 integrantes, provocando inseguridad a determinadas zonas. Conclusiones: La violencia de las barras bravas forma como parte de una característica fundamental, donde manifiestan su lucha, dolor y el riesgo de enfrentarse frente al equipo contrario.
Educación ambiental en instituciones educativas de Latinoamérica: revisión sistémica
Authors: Pizango Sandra
Published: January 2022

La Educación Ambiental en las instituciones educativas cumple una función fundamental, a nivel del sistema formativo de toda la humanidad, ya que incide en la enseñanza y aprendizaje con una sociedad ambientalmente solidaria y sostenible, capaz de mitigar los problemas medioambientales. Se trabajó con el método PRISMA, Bajo este escenario, los objetivos de dicho artículo fueron la descripción del estado de las investigaciones sobre EA así como, analizar las premisas conceptuales y los resultados obtenidos referente a EA en las Instituciones Educativas de Latinoamérica, para ello se realizó una revisión sistémica en español y portugués utilizando las siguientes bases de datos como Redalyc, Cielo, scopus, Dialnet y Ebsco, se tomó en cuenta juicios de exclusión e inclusión, se trabajó con artículos publicados entre 2018 al 2021.Entre las conclusiones se obtuvo que a nivel Latinoamérica la EA en las Instituciones Educativas ha sido objeto de investigación por su importancia no solo en lo académico sino también en la vida personal del estudiante.
Synthesis and Anti-Chikungunya Virus (CHIKV) Activity of Novel 1,4-Naphthoquinone Sulfonamide and Sulfonate Ester Derivatives
Authors: Pacheco Paulo , Gonzaga Daniel , Cirne-Santos Cláudio , Barros Caroline , Gomes Max , Gomes Rafaela , Gonçalves Mariana , Ferreira Vitor , Rabelo Vitor , Abreu Paula , Faria Robson , de Resende Gabriel , da Rocha David , Paixão Izabel , da Silva Fernando
Published: January 2022

Chikungunya virus (CHIKV) is a re-emerging disease caused by an alphavirus of the Togaviridae family. Since its first description in 1952, the disease has spread worldwide, affecting populations in both tropical and temperate countries. To date, there is no licensed vaccine or specific pharmacological treatment. Therefore, there is an increasing urgency in developing new antiviral drugs capable of specifically inhibiting viral replication. In the present work, we report the synthesis and antiviral activity evaluation of nineteen naphthoquinone derivatives, containing a sulfonamide or sulfonate group. Cell viability assays indicated a low toxic potential for all tested compounds and inhibitory assays against CHIKV identified five compounds with potent activity. The compounds were also evaluated for their virucidal potential, and the results demonstrated that compound 11a exhibited a virucidal effect higher than 70% in the treatment with 20 µM. Furthermore, in silico studies were performed to predict the antiviral drug targets.
Effects of Oils and Fats on the Quality Characteristics, Nutritional Value, and Storage Capacity of Cookies
Authors: Demchenko Elena , Savenkova Tatiana , Mizinchikova Inessa
Published: January 2022

Introduction. The quality profile and nutritional values of cookies depend on the raw material. The research objective was to study the effect of oils and fats on the quality characteristics and storage capacity of cookies.

Study objects and methods. The study involved such types of oils and fats as margarine, confectionery fat, milk fat substitute, palm oil, sunflower oil, and high oleic sunflower oil. It was based on standard methods of sensory, physicochemical, structural, and rheological analyses.

Results and discussion. The experimental formulations relied on contemporary dilatory recommendations, consumer acceptability, and traditionality of sensory indicators. The mass fraction of fat was limited to ≤ 18%; added sugars – to ≤ 22%; salt – to ≤ 0.3%. For each type of oil and fat, as set of experiments was performed to define the optimal technological emulsion and dough parameters. Other aspects involved the patterns of moisture transfer, indicators of oxidative spoilage, fatty acid composition, sensory properties, physicochemical and microbiological indicators, storage capacity, etc. The samples with vegetable oils instead of fat had a lower content of saturated fatty acids, which fell from 8–9 to 2–3 g/100 g. However, the risk of oxidative spoilage increased significantly. On storage day 104, the content of linoleic acid in the samples with sunflower oil decreased from 62.0 to 60.4%, while the samples with high oleic sunflower oil maintained the same level of linoleic acid. The samples with confectionery fat and palm oil demonstrated the lowest rate of oxidative processes, while those with margarine and milk fat substitute had the best sensory profile after storage.

Conclusion. The cookies with sunflower oil and high oleic sunflower oil appeared to have a shelf life of two months, while for those with milk fat substitute, margarine, palm oil, and confectionery fat it was six months. Further research should focus on various emulsifiers and antioxidants capable of forming bonds with proteins and starch fractions of flour, which could increase the resistance of liquid vegetable oils to oxidation.
Innovative Wastewater Treatment Technologies for Resource-Saving Activities of Feed Mills
Authors: Mizanbekova Salima , Bogomolova Irina , Vasilenko Irina , Urazova Olga
Published: January 2022

Introduction. National economies are looking for tools to activate the explicit and hidden resource potential. Innovative resource-saving projects are such a tool. Feed production strives to increase its resource efficiency.

Study objects and methods. The present research featured the feed industry of the Russian Federation and regional feed mills. It involved structural, functional, and systematic approaches and standard research methods.

Results and discussion. Liquid waste proved to be an important resource potential of modern feed production. It contains substances with high nutritional, biological, and energy value and can be used to produce methionine. The experimental part featured an industrial enterprise in the Voronezh region, which expects to produce 1452 tons of methionine worth 58 080 thousand rubles. The profitability will be 616.76%, the gross return on sales − 86.1%, the payback time – 1.44 months, the efficiency of capital investments – 8.45.

Conclusion. The innovative project will reduce the negative impact on the environment, increase the resource efficiency of the enterprise, and provide additional income.
Thermophysical Parameters of a Semi-Finished Watermelon Product as an Object of Dehumidification
Authors: Nugmanov Albert , Meshcheryakova Galina , Lebedev Viktor , Borodulin Dmitry , Aleksanian Igor , Sokolova Ekaterina
Published: January 2022

Introduction. Pectin-based protective coatings can produce a perfect biodegradable edible film. Secondary watermelon raw materials are a promising resource for this type of food coating as it contains 13.4% of pectin components, of which 8.1% is protopectin. The present research objective was to find the density and thermophysical characteristics of the pectin extract in order to optimize the drying process.

Study objects and methods. The research featured a pectin extract from watermelon rind. Its thermophysical properties were defined according to the thermocouple inertia method. The calorimetric method was used to change the aggregation state, while the pycnometric method was applied to calculate the density. The method of criterion equations helped to define the heat transfer coefficient.

Results and discussion. The average density of the final film material was 652 kg/m3 and that of the liquid semi-finished product was 1,028 kg/m3. The research also revealed the dependence of physical density and humidity W, heat capacity, thermal diffusivity, and thermal conductivity. For different W, averaged were 3393, 3225, 3137, and 3113, respectively. The study also provided the criterion dependence for determining the heat transfer coefficient and modified α on the speed of the air coolant for artificial convection at conventional coolant temperature (≈ 100°C) in contact with the food product surface (≈ 80°C).

Conclusion. The article introduces the thermophysical characteristics and physical density of watermelon gel for various humidity and thermal agent parameters, as well as a modified criterion dependence for determining the heat transfer coefficient. The research results can be used to design dehydration operations, other thermophysical processes, and their equipment.