bluuebunny/crossref_metadata_2025 huggingface dataset:
African Coastal Camera Network: Monitoring Ocean, Climate, and Human Impacts
Authors: Abessolo G. O. , Almar R. , Angnuureng D. B. , Bonou F. , Sohou Z. , Camara I. , Diouf A. , Alory G. , Onguéné R. , Mama A. C. , Cissé C. O. T. , Sy B. A. , Sakho I. , Djakouré S. , Yao S. , Tano A. R. , Bergsma E. W.J. , Dada O. A.
Published: October 2022

Regular and long-term monitoring of coastal areas is a prerequisite to avoiding or mitigating the impacts of climate and human driven hazards. In Africa, where populations and infrastructures are particularly exposed to risk, there is an urgent need to establish such a monitoring as observations are generally scarce. Measurement campaigns and very high-resolution satellite imagery are costly, while freely satellite observations have temporal and spatial resolutions that are not suited to capture the event scale. To address the gap, a network of low-cost multi-variable shore-based video camera stations is been installed along the African coasts. Here, we present this network and its principle of sharing data, methods, and results obtained, building toward the implementation of common integrated coastal management policy between countries. Further we list new contributions in the understanding of still poorly documented African beaches evolution, waves, and sea level impacts. This network is a solid platform for the development of inter-disciplinary observations for resource and ecology (such as fisheries, and sargassum landing), erosion and flooding, early warning system during extreme event, and science-based coastal infrastructure management for sustainable future coasts.
Hearing Screening Test in neonates born to COVID-19-positive mothers
Authors: Goulioumis Anastasios , Angelopoulou Maria , Kourelis Konstantinos , Mourtzouchos Konstantinos , Tsiakou Magdalini , Asimakopoulos Athanasios
Published: October 2022

Purpose
SARS-CoV-2, the responsible virus for the covid-19 pandemic, has demonstrated neurotropic properties indicated by cases presenting with auditory and vestibular system insults. The expression of ACE-2 receptors in the placenta and the detection of IgM antibodies against the virus in the fetuses of pregnant women suffering from covid-19 render vertical transmission of the infection to the fetus possible. Thus, our study aims to examine whether, similar to other viruses like CMV, SARS-CoV-2 is responsible for congenital hearing loss.
Methods
This is a retrospective study in a regional pediatric hospital. The medical records of newborns (n = 111) born by mothers positive for COVID-19 during pregnancy who underwent screening hearing tests with Transient Evoked Otoacoustic Emissions (TEOAE) and Automatic Auditory Brainstem Response (AABR) from February 2020 to June 2022 were reviewed. Neonates with additional aggravating factors for congenital hearing loss were excluded from the study.
Results
For the study period, nine mothers were found positive during the first trimester, twenty mothers in the second trimester, and eighty-three mothers in the third trimester. TEOAEs test and AABR test scored PASS bilaterally in all neonates tested.
Conclusions
Infection with COVID-19 during pregnancy was not a risk factor for hearing loss, similar to other studies.
Serum metabolome signatures characterizing co-infection of Plasmodium falciparum and HBV in pregnant women
Authors: Asantewaa Gloria , Anabire Nsoh Godwin , Bauer Michael , Weis Sebastien , Neugebauer Sophie , Quaye Osbourne , Helegbe Gideon Kofi
Published: October 2022

Background
Plasmodium falciparum (P. falciparum) and hepatitis B virus (HBV) co-infection is prevalent among pregnant women in northern Ghana and found to induce an augmented inflammatory immune response and aggravate liver damage. Both pathogens occupy a common intrahepatic niche and their activities can be characterized by specific serum metabolites in infected individuals. Thus, clarifying the metabolome signatures associated with P. falciparum and chronic viral hepatitis B co-infection could give an indication to the metabolic pathways that are impacted and provide useful prognostic or diagnostic markers.
Methods
Using MS/MS-based targeted metabolomic approach, we determined the serum metabolome in a well characterized cohort of pregnant women with either P. falciparum mono-infection, HBV mono-infection, P. falciparum and HBV co-infection or in un-infected (control) women.
Results
We observed that concentrations of sphingolipids were significantly decreased in subjects with P. falciparum mono-infection. Whereas amino acids and phospholipids were decreased in subjects with HBV mono-infection. Co-infection of the two pathogens was found to be characterized predominantly by reduced concentrations of phospholipids and hexoses (mostly glucose). Additionally, co-infection was characterized by altered pathways that contribute to redox homeostasis. Through ROC analysis, PC ae C40:1 was found to be discriminating for the co-infection group.
Conclusions
Put together, the metabolite PC ae C40:1, could serve as a potential biomarker for characterizing the co-infection, and can further be explored for use in diagnosis and treatment of malaria and chronic hepatitis B co-morbidity as well as distinguishing co-infections from cases of mono-infections.
AI-Controlled Closed-Loop Electrical Stimulation Implants: A Feasibility Study
Authors: Eickhoff Steffen , Garcia-Agundez Augusto , Haidar Daniela , Zaidat Bashar , Adjei-Mosi Michael , Li Peter , Eickhoff Carsten
Published: October 2022

Miniaturized electrical stimulation (ES) implants show great promise in practice, but their real-time control by means of biophysical mechanistic algorithms is not feasible due to computational complexity. Here, we hypothesize machine learning methods can approximate these models while being much more computationally efficient. To prove this hypothesis, we estimate the normalized twitch force of the stimulated extensor digitorum longus muscle on n=11 Wistar rats with intra- and cross-subject calibration. After 2000 training stimulations, we reach a mean absolute error of 3% in an intra-subject setting and 20% in a cross-subject setting with a random forest regressor. To the best of our knowledge, this work is the first experiment showing the feasibility of AI to simulate complex ES mechanistic models. However, the results of cross-subject training motivate more research on error reduction methods for this setting.
Voluntary running-induced activation of ventral hippocampal GABAergic interneurons contributes to exercise-induced hypoalgesia in neuropathic pain model mice
Authors: Minami Kohei , Kami Katsuya , Nishimura Yukihide , Kawanishi Makoto , Imashiro Kyosuke , Kami Takuma , Habata Shogo , Senba Emiko , Umemoto Yasunori , Tajima Fumihiro
Published: October 2022

The exact mechanism of exercise-induced hypoalgesia (EIH) in exercise therapy to improve chronic pain has not been fully clarified. Recent studies have suggested the importance of the ventral hippocampus (vHPC) in inducing chronic pain. We investigated the effects of voluntary running (VR) on glutamate (Glu) neurons and GABAergic interneurons (parvalbumin-positive [PV+] and somatostatin-positive [SOM+]) in the vHPC-CA1 region in neuropathic pain (NPP) model mice. VR significantly improved thermal hyperalgesia in the NPP model. The number of activated (FosB+) glutamate (Glu) neurons was significantly higher in partial sciatic nerve ligation-sedentary mice than in Sham and Naive mice, whereas VR significantly suppressed the activation of Glu neurons in the vHPC-CA1 region. Furthermore, VR significantly increased the proportion of activated PV+ and SOM+ interneurons in the vHPC-CA1 region, and tracer experiments indicated that approximately 24% of neurons projecting from the vHPC-CA1 region to the basolateral nucleus of amygdala were activated in NPP mice. These results indicate that feedforward suppression of Glu neurons via VR-induced activation of GABAergic interneurons in the vHPC-CA1 region may be a mechanism to produce EIH effects, and suggested that disappearance of negative emotions such as fear and anxiety by VR may play a critical role in improving chronic pain.
The accuracy of non-contrast brain CT scan in predicting the presence of a vascular etiology in patients with primary intracranial hemorrhage
Authors: Abbasi Bita , Ganjali Raheleh , Akhavan Reza , Tavassoli Ahmadreza , Khojasteh Fatemeh
Published: October 2022

Introduction: Spontaneous intraparenchymal cerebral hemorrhages (SIPH) account for 10-15% of cases of acute stroke. stratification of these patients according to the risk of harboring an underlying vascular etiology would help for selecting the patients who mostly benefit from multidetector CT angiography (MDCTA). The aim of this study was to Evaluate the accuracy of non-contrast brain CT (NCCT) in predicting the presence of a vascular etiology in patients with SIPH.
Materials and Methods: In this retrospective study, we used NCCT criteria to predict the presence of vascular etiology in SIPH patients.
Results: Of the 385 evaluated patients, 21.3% had an underlying vascular etiology. Independent predictors of the vascular etiology included age< 50 years, no history of hypertension and coagulation disorder, lobar hemorrhage, concurrent IVH or SAH, and significant perilesional edema. We used the independent predictors of vascular etiology and NCCT classification to create a practical scoring system to predict the risk of vascular ICH (VICH). VICH score ≤4 had 76.8% Sensitivity and 90.1% Specificity for prediction of a positive MDCTA.
Conclusion: The VICH score was successful in the prediction of vascular etiology in this retrospective cohort of 385 patients.
Super-Nernstian pH Sensor based on Doping-lessTunnel-Field effect transistor
Authors: Rasool Zuber , Amin S. Intekhab , Majeed Lubna , Bashir Ishrat , Seraj Anjar , Anand Sunny
Published: October 2022

In this work, we have developed doping less tunneling field-effect transistor (DL-TFET) based pH sensor which can detect the pH variation in an aqueous (electrolyte) medium. The source-sided underlapped technique is employed to achieve better sensitivity. The simulated results were extracted with the help of the software package TCAD-Silvaco. In this work, we have compared the pH sensing capabilities of both conventionally doped TFET (C-TFET) and DL-TFET having the same configuration. Result suggests that the sensitivity of DL-TFET is equal to that of C-TFET. Since DL-TFET already exhibits superiority over C-TFET in terms of better immunity against RDF, low fabrication cost and complexity, it can be used as a better alternative to C-TFET based ISFETs. Furthermore, in this work, we have discussed and demonstrated how the performance and sensitivity of the DL-TFET device can be further increased by the use of low energy band materials like germanium in the source region and high K dielectric materials like Al2O3 as a sensitive oxide layer underneath the underlapped region. The voltage sensitivity achieved by DL-TFET in this work is 312 mV/pH which surpasses the Nernst limits by more than 5 times.
Association of globalization with the burden of opioid use disorders 2019. A country-level analysis using targeted maximum likelihood estimation.
Authors: Barbalat Guillaume , Reddy Geeta , Franck Nicolas
Published: October 2022

Background
The “opioid crisis” has been responsible for hundreds of thousands deaths in the US, and is at risk of dissemination worldwide. Within-country studies have demonstrated that the rise of opioid use disorders (OUD) is linked to increased access to opioid prescriptions and to so-called “diseases of despair”. Both have been related to the emergence of globalization policies since the 1980s. First, globalized countries have seen a reorganization of healthcare practices towards quick and easy answers to complex needs, including increased opioid prescriptions. Second, despair has gained those suffering from the mutations of socio-economic systems and working conditions that have accompanied globalization policies (e.g. delocalization, deindustrialization, and the decline of social services). Here, using data with high quality ratings from the Global Burden of Disease database, we evaluated the country-based association between four levels of globalization and the burden of OUD 2019.
Results
The sample included 87 countries. Taking into account potential country-level confounders, we found that countries with the highest level of globalization were associated with a 31% increase in the burden of OUD 2019 compared to those with the lowest level of globalization (mean log difference: 0.31; 95%CI, 0.04–0.57; p = 0.02). Additional analyses showed a significant effect for low back pain (mean log difference: 0.07; 95%CI, 0.02–0.12; p = 0.007). In contrast, other mental and substance use disorders did not show any significant relationship with globalization. Finally, socio-cultural de jure globalization, which compiles indicators related to gender equality, human capital and civil rights, was specifically associated with the burden of OUD (mean log difference: 0.49; 95%CI: 0.23,0.75; p < 0.001).
Conclusions
These findings suggest that OUD may have inherent underpinnings linked to globalization, and more particularly socio-cultural aspects of globalization. Key factors may be increased rights to access prescriptions, as well as increased feelings of despair related to the erosion of local cultures and widening educational gaps.
Per-Fluorinated Azo- and Azomethane-Based Organic Polymers Developed Via Nucleophilic Aromatic Substitution Mechanism: Synthesis, Thermal, Optical Properties, Porosity and Environmental Applications
Authors: Altarawneh Suha S. , El-Kaderi Hani M. , Richard Alexander J. , Alakayleh Osama M. , Almatarneh Mansour H. , Ababneh Taher S. , Al-Momani Lo’ay A. , Aldalabeeh Rawan H.
Published: October 2022

A new series of ether-linked, per-fluorinated organic polymers bearing azo- (-N = N-) and azomethane (-C = N-) organic linkers was reported. The synthetic methodology relied on applying the nucleophilic aromatic substitution reaction (NAS) to fluorinated linkers (e.g. decafluorobiphenyl and hexaflourobenzene) and diols of azo- and azomethane linkers. The successful formation of the new structures revealing ether-linkage substitution of selected fluorine sites was confirmed by 1H-, 13C-, 19F-NMR and FTIR. All polymers were thermally stable in the range of 350–500 °C due to the variation of fluorine and nitrogen contents. The extended conjugation of the polymers was confirmed by the changes in the UV-Vis spectra of the organic linkers and their corresponding polymers. A notable hypsochromic shift was observed in all cases, which was more pronounced with azo-based fluorinated chains due to the H-bonding on the nitrogen sites, chain conformations and planarity. The optical band gap (Eg) of the polymers was determined from the UV-Vis. The Eg values of azo-based fluorinated polymers were higher by 1eV compared to their corresponding linkers. The 19F-NMR analysis confirmed two types of NAS on both the ortho- and para- positions of the fluorinated linkers. These connections created the possibility of developing cross-linked frameworks beside the open-chain confirmation with tailored hydrophobic nature. The cross-linking formation was characterized by porosity measurements, including surface area (SA), pore size and pore volume. The highest measured values were recorded for the azo-based polymer (DAB-Z-1h), which reached 438 m2/g and a pore volume of 0.35 cm3/g. A surface area of 105 m2/g was the lowest for the open-chain azomethane-based polymer (DAB-A-1O) with a pore volume of 0.0872 cm3/g. The beneficial formation of porous structures with varied hydrophobic nature was investigated as adsorbents for separating water/benzene, water/phenol and the selective binding of methane/carbon dioxide gases from the air. The most hydrophobic polymers that contain the decafluorbiphenyl linker were suitable for benzene separation, and the superior methane uptake values were 6.14 and 3.46 mg/g, for DAB-Z-1O and DAB-A-1O, respectively. On the other hand, DAB-Z-1h, with the highest surface area (438 m2/g) and rich with nitrogen sites, has the highest CO2 uptake at 298 K (17.25 mg/g).
Best Thermoelectric Efficiency of Ever-Explored Materials
Authors: Ryu Byungki , Chung Jaywan , Kumagai Masaya , Mato Tomoya , Ando Yuki , Gunji Sakiko , Tanaka Atsumi , Yana Dewi , Fujimoto Masayuki , Imai Yoji , Katsura Yukari , Park SuDong
Published: October 2022

A thermoelectric device is a heat engine that directly converts heat into electricity. Many materials with a high figure of merit ZT have been discovered in anticipation of a high thermoelectric efficiency. However, there has been a lack of investigations on efficiency-based material evaluation, and little is known about the achievable limit of thermoelectric efficiency. Here, we report the highest thermoelectric efficiency using 13,353 published materials. The thermoelectric device efficiencies of 808,610 configurations are calculated under various heat-source temperatures (Th) when the cold-side temperature is 300 K, solving one-dimensional thermoelectric integral equations with temperature-dependent thermoelectric properties. For infinite-cascade devices, a thermoelectric efficiency larger than 33% (≈1/3) is achievable when Th exceeds 1400 K. For single-stage devices, the best efficiency of 17.1% (≈1/6) is possible when Th is 860 K. Leg segmentation can overcome this limit, delivering a very high efficiency of 24% (≈1/4) when Th is 1100 K.
Genetic diversity of viruses infecting cnidium plants (Cnidium officinale) in Japan: cnidium vein yellowing virus (CnVYV), cnidium virus X (CnVX) and cucumber mosaic virus (CMV)
Authors: Iwai Kazuma , Kon Tatsuya , Abe Haruki , Honma Hiroshi , Kawasumi Naoki , Kawakami Hiroko , Kawashimo Midori , Sakurai Miki , Fuji Shin-ichi
Published: October 2022

We report the infection efficiency and genetic diversity of three different viruses, cnidium yellowing vein virus (CnVYV), cnidium virus X (CnVX), cucumber mosaic virus (CMV), which are associated with yellowing and mosaic symptoms in Cnidium officinale plants in Iwate and Hokkaido, Japan. The rate of viral infection is extremely high and we found that all collected samples were infected with CnVYV. Phylogenetic analysis using coat protein (CP) sequences suggested that these three viral species had infected before or just after the cnidium plants were introduced in Japan.
Proximal Hyperdense Middle Cerebral Artery Sign is Associated with Increased Risk of Hemorrhagic Transformation after Endovascular Thrombectomy: A Multi-center Retrospective Study
Authors: Kang Zhiming , Wu Lishuo , Sun Dong , Zhou Gang , Wu Xiangbo , Qiu Han , Mei Bin , Zhang Junjian
Published: October 2022

Objective: To investigate whether hyperdense middle cerebral artery sign (HMCAS) on pretreatment no-contrast CT (NCCT) is associated with hemorrhagic transformation (HT) after endovascular thrombectomy (EVT).
Methods: Patients with acute middle cerebral artery (MCA) occlusion who received EVT between January 2018 and December 2021 in three comprehensive hospitals were retrospectively evaluated. They were divided into negative HMCAS, proximal HMCAS, and distal HMCAS groups, among whom differences were compared. Univariate and multivariate logistic regression analysis were performed to investigate the association between HMCAS and HT.
Results: 318 patients were included, among whom 149 (46.9%) had HMCAS with 107 (71.8%) in the proximal HMCAS group and 42 (28.2%) in the distal HMCAS group. Patients with proximal HMCAS had higher National Institute of Health Stroke Scale scores (p = 0.006) and lower Alberta Stroke Program Early CT Scores (p < 0.001). Large artery atherosclerosis was more frequent in the negative HMCAS group while cardioembolism was more common in the positive HMCAS groups (p = 0.007). The rate of HT was higher in the proximal HMCAS group than that in the negative HMCAS group (61.7% vs 43.2%, p < 0.05). Proximal HMCAS was associated with HT in univariate analysis (unadjusted OR = 2.117, 95%CI: 1.291–3.471, p = 0.003) and remained an independent risk factor of HT in multivariate logistic regression analysis (adjusted OR = 1.989, 95%CI: 1.170–3.380, p = 0.011).
Conclusion: Proximal HMCAS on initial NCCT was independently associated with HT in patients who received EVT for acute MCA occlusion.
SCL-SKG:Software Knowledge Triplet Extraction with Span-level Contrastive Learning
Authors: Tang Mingjing , Zhang Shu , Zheng Ming , Ma Zifei , Gao Wei
Published: October 2022

The text of software knowledge community contains abundant knowledge of software engineering field. The software knowledge triplet can be extracted automatically and efficiently to form the software knowledge graph, which is helpful for software knowledge-centric intelligent applications, such as intelligent question answering, automatic document generation and software expert recommendation. Most existing methods are confronted with problems of task dependence and entity overlap. In this paper, we propose a software knowledge triplet extraction method based on span-level contrastive learning. From the level of sentence sequence modelling, we model the sentence sequence with span as a unit, and generate abundant positive and negative samples of entity span through the span representation layer to avoid the problem that the token-level method cannot select overlapping entities. From the level of feature learning, we propose supervised entity contrastive learning and relation contrastive learning, which obtain enhanced feature representation of entity span and entity pair through positive and negative sample enhancement and contrastive loss function construction. Experiments are conducted on the dataset which is constructed based on texts of the StackOverflow, and show that our approach achieves a better performance than baseline models.
Design, preparation and characterization of Fe 3 O 4 @SiO 2 @ECH@Thiocarbazide@Au(III)@Chitosan nanoparticles as a catalyst for the synthesis of 3, 4-dihydropyrano [3,2 -c]chromenes
Authors: Karkon Elahe Gholamiyan , Mostafavi Hossein
Published: October 2022

A magnetic nanostructured iron/silica/ linker/ gold ions/ chitosan, has been synthesized to achieve an efficient and reusable catalyst characterized by X-ray diffraction, scanning, and transmission electron microscopies, energy-dispersive X-ray spectroscopy, thermogravimetric analysis, Fourier transform infrared spectroscopy, vibrating sample magnetometry, and inductively coupled plasma optical emission spectrometry. To improve their stability and increase surface the achieved multilayer nanocomposite has been capsulated in chitosan and glutaraldehyde network. It was found that the obtained nanoparticles have diameter size from 43 to 72 nm. The optimized nanocatalyst applied an efficient and easy friendly procedure for the synthesis of 3, 4-dihydropyrano [3,2-c]chromenes from aromatic aldehyde or aromatic glyoxal, malononitrile, and cyclohaxane-1,3-dione in water at room temperature. The prepared nanocatalyst will be quickly recovered employing an external magnet and reused several times without significant activity loss.
Multi-source sensor data and worn surface topography for tribo-informatics research
Authors: Ma Yufei , He Ke , Yin Nian , Zhang Zhinan
Published: October 2022

Real-time monitoring of the wear state of key components of mechanical equipment is one of the key engineering applications of tribology. It can be realized with the help of data-driven technology. In this study, the multiple-source sensor data and the surface topography of the disc specimen during the tribo-test were collected using the pin-on-disc test. The pin material was polyimide, and the disc material was titanium alloy. During the test, the surface topography of the disc specimen was collected by restarting multiple times for single pair of specimens. The data collected by the sensors of the tribometer itself include the applied normal load, the measured friction force, the calculated friction coefficient, the position of the pin, and the rotational speed of the disc. The data collected by the data acquisition platform include the vibration data in three directions, sound pressure, and audio data. The data collected by the white-light interferometer are the surface topography of the four worn areas on the disc. These data can be used to explore the trend of surface topography during the friction process and to verify the performance of different data-driven methods in studying the correlation between surface topography and multi-source sensor data.
SH3 Domain-Binding Glumatic Acid-Rich Protein-Like 3 is closely associated with hyperglycemia and poor outcome in Epstein-Barr Virus-negative Gastric Carcinoma
Authors: Li Houqiang , Zheng Lanqing , Fu Peiling , Chen Xin , Zhang Xia , Yu Xunbin , Chen Zhizhong , Zhong Guodong , Chen Xiaoyan , Lu Mei , Chen Linying
Published: October 2022

Background
SH3 domain-binding glutamate acid-rich protein-like 3 (SH3BGRL3) has recently been indicated in several human cancers. However, its relationship with gastric cancer (GC) remains exclusive.
Methods
Using multiple online bioinformatic tools to evaluate the messenger RNA(mRNA) levels of SH3BGRL3 in GC from the database of The Cancer Genome Atlas, Genotype-Tissue Expression, and Gene Expression Omnibus. RT-qPCR and tissue microarray-based immunohistochemistry were performed to observe SH3BGRL3 expression concerning clinicopathological parameters and outcomes in GC patients. Significantly differentially expressed genes (DEGs) of SH3BGRL3 were enriched and visualized. Meanwhile, the associations between SH3BGRL3 expression and immune infiltrating cells were explored.
Results
SH3BGRL3 exhibited aberrant expression in tumor tissues compared to the adjacent normal tissues at mRNA levels and protein expression, especially in EBVnGC. Higher SH3BGRL3 expression is significantly associated with increasing TNM staging, tumor budding, perineural invasion, EGFR expression, and a notably higher preoperative blood glucose concentration in clinical specimens. Multivariate analysis revealed that higher SH3BGRL3 expression was an independent adverse prognostic factor for the overall survival of EBVnGC patients (HR = 1.666, p = 0.018). Furthermore, the stratified analysis showed SH3BGRL3 phenotype could refine prognostication in patients. The C-index of the nomogram was 0.740 when combining SH3BGRL3 with other clinicopathological parameters, which indicated a good model for clinical follow-up decisions. Gene functional enrichment analysis revealed that the DEGs of SH3BGRL3 were mainly enriched in regulating ATP metabolism, ATP synthesis, oxidative phosphorylation, and electron transport chain in GC. Higher SH3BGRL3 expression was significantly positively correlated with the infiltrating macrophages in GC.
Conclusion
SH3BGRL3 was upregulated in GC, particularly in EBVnGC. Higher SH3BGRL3 expression was closely associated with hyperglycemia and poor outcomes in EBVnGC patients, suggesting a potential biomarker and prognostic predictor.
Combination of baseline PET/CT total metabolic tumor volume, lesion dissemination and TP53 mutations predicts rapid progression of diffuse large B-cell lymphoma
Authors: Liu Cong , Shi Pengyue , Li Zhenjiang , Li Baosheng , Li Zengjun
Published: October 2022

Background: The existing International Prognostic Index (IPI) scoring system has failed to fully identify high risk population for diffuse large B-cell lymphoma (DLBCL). The next-generation prognosis model may combine PET scanning indicators, total metabolic tumor volume (TMTV) or the largest distance between 2 lesions (Dmax) normalized with the body surface area [standardized Dmax (SDmax)], and genetic mutations to identify high-risk patients early.
Methods: We analyzed 93 patients with DLBCL treated with rituximab and CHOP/CHOP-like regimen. TMTV was calculated using the 41% maximum standardized uptake value thresholding method. From the 3D coordinates, the centroid of each lesion was automatically obtained and considered as the lesion location; Dmax was calculated and normalized by patient body surface area (BSA), given by √(weight x height)36 00, yielding SDmax. The pathological tissues of all patients before treatment were sequenced by a lymphopanel to identify mutations in 43 genes.
Results: The optimal TMTV cutoff was 210.1 cm3, and the optimal SDmax cutoff was 0.146 m-1. In multivariate analysis, high SDmax, high TMTV and A53-like subtype were independent prognostic factors of PFS (P=0.047, 0.035 and 0.031, respectively). TMTV or SDmax combined with TP53 mutations can identify significant risk stratification in patients. TMTV combined with TP53 mutations identified 3 groups with a significant difference in PFS (P=0.003): 42 patients with low TMTV regardless of TP53 status; 36 with high TMTV and wild-type TP53; and 15 with high TMTV and mutant TP53. In the three groups, 1-year PFS was 81.4%, 55.4% and 38.9%, respectively. SDmax combined with TP53 mutations also identified 3 groups with a significant difference in PFS (P < 0.001), and 1-year PFS was 84.8%, 58.3% and 32.0%, respectively.
Conclusions: In patients with low tumor burden or without distant metastasis, gene mutations seems to have little effect on prognosis. While in patients with heavy load, combination of TMTV or SDmax with TP53 mutations could lead to more accurate selection and better individualized treatment. Based on this study, we suggest that next-generation sequencing should be carried out in the newly diagnosed patients with heavy tumor load or distant metastasis in the future, so as to further distinguish the high-risk patients and guide the treatment.
Catastrophic health expenditure and its inequality in rural China: evidence from 2013-2018 CHARLS
Authors: ZHang Weile , Su Min , Li Dongxu , ZHang Tianjiao , Li Wenhui
Published: October 2022

Background: Catastrophic health expenditure (CHE) is an important indicator for measuring health inequality. Previous studies mainly focused on whole populations rather than specific vulnerable groups through the regional survey or cross-sectional data. China’s rural area is often associated with an underdeveloped economy and insufficient health resources. This study aims to update the information on the extent and trends in incidence and inequality of CHE among the households of rural China through CHARLS panel data.
Methods：Data were obtained from three waves of the China Health and Retirement Longitudinal Study (CHARLS): 2013, 2015, and 2018. CHE was defined as the proportion of household health expenditures to the non-food expenditure more than 40% threshold. The inequality of CHE was measured by the concentration index. Decomposition methods were used to decompose the concentration index into its determining components.
Results：The incidence of CHE was 23.41% (95% CI: 0.22, 0.25) in 2013, 21.36% (95% CI: 0.20, 0.23) in 2015 and 28.97% (95% CI: 0.27, 0.31) in 2018 in rural households. The concentration index was negative: -0.1528 (95% CI: -0.1941, -0.1115) in 2013, -0.1010 (95% CI: -0.1442, -0. 0577) in 2015 and -0.0819 (95% CI: -0.1170, -0.0467) in 2018. Economic status, age, and chronic disease were the main contributors to the inequality of CHE.
Conclusions：The incidence of CHE in rural households of China displayed an upward trend. Furthermore, there existed a strong pro-poor inequality of CHE in rural China. Economic status, age, and chronic diseasewere the main contributors to the pro-poor inequality. Health policies to allocate resources and services are needed to satisfy the needs of rural households and provide more accessible and affordable health services. More concerns need to be directed toward households with chronic diseases and households with the elderly. Meanwhile, policymakers need to pay more attention to relieving the incidence of CHE and promoting health equality.
WITHDRAWN: Opponensplasty Using Distal Nerve Transfer in High Median Nerve Injuries: a Case Series
Authors: Emamhadi Mohammadreza , Dogahe Mohammad Haghani , Emamhadi Amirreza
Published: October 2022

Purpose
High median nerve injury leads to absence of thumb opposition and irreversible thenar atrophy. Currently, distal nerve transfer is a new option for opponensplasty. The superiority of nerve transfer over traditional tendon transfer is that in nerve transfer, all thenar muscles may be reinnervated and so thumb functions are fully achieved while in tendon transfer, the goal is to reanimate the function of abductor pollicis brevis. This study aims to describe the results of opponensplasty using distal nerve transfer.
Methods
This article analyses the results of opponensplasty using transfer of abductor digiti minimi branch of the ulnar nerve to recurrent branch of the median nerve. Clinical outcomes were assessed by objective evaluation of abductor pollicis brevis (APB) strength, degree of thumb opposition, and thenar muscle bulk. APB strength and degree of thumb opposition measured by Medical Research Council (MRC) and Kapandji scoring systems, respectively.
Results
From 2016 to 2019 six patients of mean age of 29.5 years (five males and one female) with high median nerve injury were considered for opponensplasty using nerve transfer. Clinical improvement including regaining APB strength and thumb opposition was achieved in all patients. Moreover, recovery of thenar atrophy was observed in five patients.
Conclusions
In high median-nerve injury, early reconstructive intervention can prevent the thenar muscle atrophy and leads to prompt reinnervation and complete restoration of thenar function. Abductor digiti minimi branch of the ulnar nerve is a superior donor for this purpose.
MOM-VMP: Multi-Objective Mayfly Optimization algorithm for VM Placement supported by Principal Component Analysis(PCA) in Cloud Data Center
Authors: Durairaj Selvam , Srid Rajeswari
Published: October 2022

Virtual Machine Placement (VMP) is crucial in a cloud data cen-ter(CDC). It is a critical step carried out as part of the Virtual Machine (VM) placement to allocate the best Physical Machine (PM) to host the VMs. The efficacy of the virtual machine placement strategy has a considerable impact on cloud computing efficiency. The ineffec-tiveness of the VMP approach has a major negative impact on the CDC.Virtualization facilitated VM migration has met the ever-increasing demands of dynamic workload by transferring VMs inside CDC. Many resource management goals, including power efficiency, load balancing, fault tolerance, and system maintenance, are aided VM placement. As a result, VMP needs to assess characteristics that may impact placement performance and energy efficiency. Most past research has concentrated solely on reducing energy consumption while ignoring SLA (service level agreement) breaches, enhancing the resource usage of PMs, and ignoring the over-commitment issue. MOM-VMP To propose a multiobjective Mayfly VMP algorithm (MOM-VMP) meta-heuristic optimization algorithm with a massive CDC with different and multi-dimensional resources to handle these issues. A multi-objective dynamic VMP strategy is employed to reduce resource wastage, overcom-mitment ratio, migration time, SLA violation and energy consumption at the same time. This paper presents a dynamic multi-objective VMP in CDC based on overcommitment resource allocation to influence VM-PM mapping. We validated our method of conducting a performance evaluation study using the CloudSim tool. The experimental findings show that the suggested study decreases energy consumption, makespan, SLA violations, and PM overloading while enhancing resource utilization.
The Musical Turn in Biosemiotics: An Expressivist Model of Communication
Authors: Slayton Matthew , Hendlin Yogi
Published: October 2022

Human music and language are two systems of communication and expression that, while historically considered to overlap, have become increasingly divergent in their approach and study. Music and language almost certainly co-evolved and emerged from the same semiotic field, and this relationship as well as co-origin are actively researched and debated. For the sake of evaluating the semiotic content of zoomusicology, we investigate music from a ‘bottom-up’ biosemiotic functionalist account considering iconic, indexical, and symbolic forms of meaning not in a hierarchy but according to their effects on agents. Such an approach avoids overintellectualizing the representational aspects of music, and instead inverts, as it were, the traditional hierarchy of semiotic categories to produce illocutionary effects. Understanding aesthetics and action not as a priori separate but rather fundamentally co-arising elements of the same events, the focus of musicality again returns to interpretation and how semiosis precipitates expression.
A novel cuproptosis-related gene signature for the prediction of liver cancer prognosis identified DLAT is a potential therapeutic target
Authors: Xu Dong , Yang Fei , Chen Yang , Zhu Hong , Sun Haijian , Shen Tong , Zhu Yongkang , Zhou Guowei , Chen Dexuan , Yang Xiaojun , Lin Kai , Xia Cunbing
Published: October 2022

Background and Purpose: The liver cancer (LC) is a highly malignant tumor of the digestive system with a poor prognosis. Cuproptosis is a new type of regulated cell death that has been found by researchers. The expression of cuproptosis-related genes in LC and their relevance to prognosis, on the other hand, remain unknown. This study aimed to explore a gene signature to predict the liver cancer prognosis and identified the vital gene.
Experimental approach: The expression patterns of RNA and related clinical data of 371 LC patients were obtained based on The Cancer Genome Atlas (TCGA). Differentially expressed genes (DEGs) were acquired by comparing tumors with adjacent normal samples. Genes displaying significant association with OS were screened through univariate Cox regression analysis and the least absolute shrinkage and selection operator (LASSO) algorithm. All cases were classified into the validation or training group to validate the constructed gene signature. We conducted real-time polymerase chain reaction (PCR) and assays for transwell invasion, CCK-8, and colony formation to determine the biological roles of DLAT. Key Results: The differential expression of twelve cuproptosis regulators in LC and normal liver tissues was discovered in this investigation. DEGs can be used to distinguish between two forms of LC. Cuproptosis-related genes were evaluated for survival predictive significance using the Cancer Genome Atlas (TCGA) cohort. A 3-gene signature based on least absolute shrinkage and selection operator (LASSO) Cox regression was used to categorize an LC patient cohort from the TCGA into low- and high-risk categories. Patients in the low-risk group had a considerably higher likelihood of surviving (P = 0.05) than those in the high-risk group. When paired with clinical parameters, risk score was an independent predictor in predicting the OS of patients with LC.
Conclusions & Implications: Cuproptosis-related genes thus play an important role in tumor formation and can be used to predict the prognosis of LC patients. DLAT has the best prognostic value and can be a therapeutic target for liver cancer.
The Structure And Theme in The Novel “Taaşşuk-ı Talat ve Fitnat” by Şemsettin Sami
Authors: KARADENİZ Havvaana
Published: October 2022

Türk edebiyatında roman türünün ilk örneklerinden biri olan Taaşşuk-ı Talât ve Fitnat, Tanzimat döneminde sıkça ele alınan, birbirine âşık iki gencin eski gelenek ve göreneklerin etkisiyle bunalıma ve ölüme sürüklenişinin gözler önüne serildiği bir romandır. Devrin toplumsal bir sorunu hâline gelen görücü usulü ile evliliğin doğurduğu vahim sonuçlar ve ailelerin gençler üzerinde oluşturduğu baskı, romanda üzerinde durulan en temel noktalardır. Taaşşuk-ı Talât ve Fitnat romanında orta sınıf ailelerinin hayatlarının anlatıldığı görülür. Görücü usulü ile evliliği sert bir dille tenkit eden roman, aslında insanların derin ruh tahlillerinin yapıldığı bir gelenek-görenek/örf ve âdet romanıdır. Roman genel olarak insan şahsiyetine, hürriyete ve tabiata aykırı olan eski örf ve âdetlerin, bireyleri ve toplumu felakete sürükleyişini anlatır. Bu nedenle değişmez gibi algılanan birtakım değerlerin de sorgulanabileceği mesajını verir. Toplumun düşünce yapısını tüm gerçekleri ile gözler önüne sermeye çalışan yazar, aşk duygusunu kullanır ve anlatı boyunca “aşk”ın devrin kurallarına göre kurgulandığı görülür. Ayrıca romanda eser aracılığı ile toplumu eğitme çabası ve toplumsal fayda ön planda tutulur. Taaşşuk-ı Talât ve Fitnat romanında entrik kurguyu oluşturan ve çatışmayı sağlayan değerler, “KORA şeması”yla tablolaştırılmıştır. Böylece romanın yapısını oluşturan zaman, mekân, olay örgüsü, bakış açısı ve karakterler hakkında bilgi verildikten sonra romanın arka planında verilmek istenen ülkü (tematik) değerler ve karşı değerler çalışmada sunulmuştur.
Why Does a Country Assist Another?The Origins and Evolution of Development Assistance, as well as Donor Motivations
Authors: İPEK Esat
Published: October 2022

In addition to the development approaches they adopt, countries that are in the position of donor and provide development assistance may have different orientations according to the beneficiary country they are dealing with, the global conjuncture they are in, and the methods they prefer. These factors and many other factors constitute the motivation of donor countries to offer assistance. Herein, donors acting according to their national strategic priorities, donors taking positions according to their position in the global economic order, donors which display different attitudes according to the beneficiary country they deal with, and donors which evaluate development assistance in the context of international relations have different motivations. In the study, primarily, the concept of development assistance was conceptually discussed, and the theoretical foundations on which it is built were explained. Afterward, historical changes and transformations were discussed. The donor countries' motivation to offer assistance, which is the main focus of the study, was examined through the categorization of countries that have common characteristics among themselves. In this context, a heading was specifically opened for Turkey, and Turkey's history of development assistance was included as well. Moreover, the role played by international organizations, which are among the most important actors in this field, in the provision of assistance was also discussed under a separate heading.
ANTİ-VACCİNATİON EXAMPLE ON TWİTTER, A PUBLİC OPPOSİTİON TOOL: “#HADDİBİLAZİZSANCAR”
Authors: BALCI AYDOĞAN Bahar , ABUŞOĞLU Hilal Özlem
Published: October 2022

Sosyal medya platformları bireylerin bilgi edinme, haber alma ve fikirlerini özgürce ifade edebildikleri bir kamusal zemindir. Bu amaçla en sık kullanılan sosyal medya araçlarının başında Twitter gelmektedir. Öyle ki Twitter da oluşturulan hastagler ile dikkat çekilmek istenen konuyla ilgili global çapta bir örgütlenme olanaklı hale gelmektedir. Bu araştırma sosyal medyadaki aşı karşıtı söylemleri incelemek ve aşının reddedilme nedenlerini ortaya koymayı amaçlamaktadır. Bu bağlamında 19-21 Şubat 2022 tarihleri arasında Twitter’da “#HaddiBilAzizSancar” hastagi ile atılmış 19.435 tweet NodeXL Pro Sürümü aracılığı ile çekilmiştir. Elde edilen bu veriler sınıflarına ayrıldığında 267 mentions, 878 mentionsln retweet, 417 replies to, 12.680 retweet ve 5193 tweet ortaya çıkmıştır. 5193 tweet içinden de tekrar tweetler ile konuyla alakalı olmayan tweetler çıkarılınca analize tabi tutulacak 1163 tweet elde edilmiştir. Daha sonra bu tweetler içerikleri dikkate alınarak belli kategorilere ayrılmış ve betimsel analizi yöntemiyle yorumlanmıştır. Aynı zamanda NodeXL programıyla “#HaddiBilAzizSancar” hastaginin ağ görselleştirmesi üzerinden yapılan bir değerlendirme ile çalışma desteklenmiştir. Analiz sonucunda aşıların içeriklerine yönelik önyargı, aşılamanın altında komplo teorilerinin olduğu savı ve dini temelli gerekçelerle insanların aşıları reddettikleri sonucuna varılmıştır. Ayrıca atılan tweetlerin bir kısmında ise insanların sadece aşı karşıtlığı değil pandemi karşıtlığı yaptıkları da görülmüştür.
ECONOMIC MEASURES AND APPLICATIONS TAKEN BY THE GOVERNMENT OF CUP AND PROGRESS ON THE WAY TO THE FIRST WORLD WAR: AN EVALUATION ON THE AXIS OF WAR ECONOMY
Authors: ARSLAN Lütfi
Published: October 2022

Savaş kavramı, askeri ve siyasi yönü kadar toplumsal hayatı etkileyen ekonomik yönüyle de ön plana çıkmaktadır. Sanayi İnkılabının savaş sektörüne uygulanması ile şekillenen XIX ve XX yüzyıldaki değişim ve dönüşüm, dünyanın o güne kadar görmediği ilk büyük harbin 1914’te patlak vermesine yol açmıştır. Harpler, I. Dünya Harbi ile sosyal ve iktisadi hayatın baştan sona düzenlenmesini gerekli kılmıştır. Bu durum savaş ekonomisine yönelik yeni tedbirlere yol açmıştır. Osmanlı Devleti I. Dünya Harbi’nin getirdiği askeri tedbirler yanında, harbin sürekliliğini sağlamak, toplumsal ihtiyaçları karşılayabilmek ve en önemlisi ulusal çıkarları korumak adına bazı tedbir ve uygulamaları hayata geçirmiştir. Bu kapsamda savaş ekonomisine yönelik olarak olağanüstü harp masraflarını karşılamak için Balkan Harbi Döneminde çıkarılan “Harp Vergisi” alınmaya devam etmiştir. Ayrıca ordunun finansmanını sağlamak amacıyla İttihat ve Terakki Hükümeti tarafından “Tekalif-i Harbiye Kanunu” çıkarılmıştır. Bununla halkın ihtiyaç fazlası ürünlerine el konulması kararlaştırılmıştır. Bunun yanında memur maaşlarının yarısının ödenmesi, Almanya ve Avusturya-Macaristan’dan borç alınması, emisyon, devlet tahvili satma, kapitülasyonların kaldırılması diğer uygulamalar arasındadır. Ticaret odası ve bankaların isteği üzerine iç ve dış borç ödemeleri ertelenerek, yiyecek maddeleri ve hayvan ihracatı durdurulmuştur. Bu çalışmada İttihat ve Terakki Hükümeti’nin I. Dünya Harbi’nde savaş ekonomisine yönelik aldığı tedbir ve uygulamalar arşiv belgeleri ve araştırma eserler ekseninde ele alınmıştır.
Examining Economic Security as a Human Security Element Within the Perspective of Basic Income
Authors: DUMAN Gökhan , YILMAZ Serhat
Published: October 2022

Dönüşen güvenlik kavramı sonrası bugün tartışılan insani güvenlik ve onun yedi unsurundan biri olan ekonomik güvenlik kavramı yeni güvenlik yaklaşımının temelini oluşturmaktadır. İnsani ve ekonomik güvenlik görece çok yeni tartışılıyor olsa bile aslında ekonomik güvenliğe ilişkin temel gelir düşüncesi on üçüncü yüzyıla kadar uzanır. Vatandaşlık maaşı, devlet bonusu, bölgesel temettü gibi farklı adlandırmalara da sahip olan temel gelire dönük birçok teorik tartışma ile, bu teorilerin deneyimlenmesine dönük birçok pratik mevcuttur. Mevcut kapitalist sistemde temel gelirin alternatif bir sosyal politika aracı olup olamayacağı yoğun tartışılmakla birlikte Kovid-19 pandemisi ile de bu tartışmalar doruğa ulaşmıştır. Buradan hareketle bir araştırma çalışması niteliği taşıyan makalede, insani güvenlik yaklaşımı ve onun altında ekonomik güvenlik kavramı temel gelir perspektifinde incelenecek olup, temel gelire ilişkin temel tartışmalar ve pratikler üzerinde durulacaktır.
IMAGIC DISCOURSE IN FEHÎM-I KADİM'S GAZEL “Mİ OLDUN” REDİF
Authors: AÇAR Zeliha
Published: October 2022

İmge, en genel tanımıyla dış dünyaya ait nesnel gerçekliğin zihinde bıraktığı intibadır. Başka bir deyişle şairin, dış dünyadan aldığı zihinsel uyarımları yeni bir teşbih yahut da metafor olarak ifade ediş şeklidir. Bir söz ya da söz grubunun akla ilk gelen manası dışında bir veya birden fazla manayı çağrıştırması olan imge, şiirin değer kazanmasında önemli bir role sahiptir. İmgenin gücünden istifade etmek de şiir dilinin zenginliğinin doğal bir sonucudur. İmgesel söylem, gündelik dilden farklı olarak yaratılmış olan dilin imkânlarını zorlayarak inşa edilmiş olan yeni dille manayı katmanlı hâle getirmektir. Klasik şiirin kuruluş dönemlerinde basit mazmunlar kullanılırken sonraki dönemlerde şiirdeki incelmelerle hayaller genişlemiştir. Bilhassa girift hayallerle zincirleme tamlama ve orijinal terkipleri kullanan Sebk-i Hindî şairlerinde çarpıcı yeni imajlar yaratma girişimleri neticesinde imgesel anlatım daha da yaygınlaşmıştır. Bu çalışmanın konusu Fehîm-i Kadîm’in “mi oldun” redifli gazelinin sembol dünyasıdır. Çalışmaya konu olan şiirin şairi Sebk-i Hindî’in ustalarından olduğundan öncelikle bu edebî akım ve şairin biyografisi hakkında bilgi verilecek, daha sonra da şiir incelenerek sonuca bağlanacaktır.