bluuebunny/crossref_metadata_2025 huggingface dataset:
Conhecimento dos pacientes com doença falciforme acerca do tratamento fisioterapêutico
Authors: Do Sacramento Marvyn de Santana , Cordeiro André Luiz Lisboa , Dos Santos Alan Carlos Nery , Petto Jefferson , Mata Cauê Santos da , Silva Vitor Correia da
Published: November 2018

INTRODUÇÃO: Doença Falciforme (DF) é uma doença genética recessiva que compromete o funcionamento de órgãos e sistemas, influenciando negativamente na qualidade de vida, funcionalidade e capacidade funcional. Portanto, é imprescindível que esses pacientes sejam devidamente informados sobre as opções terapêuticas existentes, visando minimizar complicações oriundas da doença de base e das comorbidades associadas. OBJETIVOS: Descrever o conhecimento dos pacientes com DF sobre tratamento fisioterapêutico. MATERIAIS E MÉTODOS: Estudo transversal e descritivo, no qual 50 indivíduos com doença falciforme, 26(52%) mulheres sendo 43(86%) do genótipo SS e 7(14%) SC. Todos responderam a um questionário semiestruturado elaborado pelos pesquisadores, o qual coletou informações sobre diagnóstico, tempo de tratamento, enfermidades associadas, internamento, orientação pela equipe de saúde, conhecimento da fisioterapia como tratamento, realização de tratamento fisioterapêutico, sentimento após tratamento fisioterapêutico, tempo de realização da fisioterapia e interesse em informações sobre tratamento fisioterapêutico. RESULTADOS: Quarenta e oito voluntários (96%) foram hospitalizados por complicações da doença e apenas 19(38%) dos indivíduos tiveram o diagnóstico da doença na triagem neonatal. Problemas musculoesqueléticos foram os mais frequentes 50(100%), seguido de pneumonia 28(56%). Apenas 4(8%) voluntários estavam em tratamento fisioterapêutico, sendo que 34(68%) nunca tinham passado pela fisioterapia, 4(8%) receberam indicação para o tratamento fisioterapêutico pelo médico que os acompanhava e 10(20%) receberam informações da equipe de saúde. Quando questionados se desejavam ter recebido informações sobre os benefícios que a fisioterapia poderia trazer, 49(98%) relataram ter o interesse nessas informações. CONCLUSÃO: Indivíduos com Doença Falciforme não possuem o conhecimento devido sobre a fisioterapia e não são devidamente orientados sobre a possibilidade do tratamento fisioterapêutico.
Effectiveness of the low-molecular inductor of interferon of Amiksin® in treatment and preventive maintenance of the chronic recurrent inflammatory diseases of the upper respiratory tract
Authors: Shulzhenko A. E. , Zuikova I. N. , Karaulov A. V. , Shchubelko R. V.
Published: November 2018

Introduction. In the formation of recurrent and/or prolonged chronic inflammatory diseases of the upper respiratory tract in addition to the known, previously studied, factors that play an important role in the violation of the human immune system at the level of local (mucosal) and systemic immunity and activation of herpes virus group (Epstein Virus Barr virus, cytomegalovirus, herpes simplex virus type 6). In the treatment of herpesvirus infections, activation of antiviral immunity in domestic medicine used drugs interferon inducer. Objective. To evaluate the efficacy of interferon inductor Amiksin® in patients with chronic recurrent inflammatory diseases of the upper respiratory tract. Materials and methods. Based on separation of “Allergy and Immunotherapy” SSC “Institute of Immunology” FMBA studied low-molecular interferon inductor Amixin® (JSC “Pharmstandard-Tomskhimpharm”, Russia) in the treatment of chronic recurrent inflammatory diseases of the upper respiratory tract. The study included 40 patients between men and women, aged 18 to 65years old with a history of recurrent chronic inflammatory diseases of the upper respiratory tract. Clinical research methods included a medical history, previous efficiency of the treatment, the presence of comorbidities. Laboratory methods include bacteriological crop on flora in the material from the oropharynx and the detection of DNA viruses of herpes group in saliva. Patients of the main group, after clinical and laboratory examination, prescribed therapy with Amixin®. Patients in both groups received symptomatic therapy. The total duration of observation of each patient was 3 months. Results. Amiksin® receiving the drug in patients with acute exacerbation of chronic recurrent upper respiratory tract inflammatory diseases contributed to a more rapid relief of general and local symptoms. Also it found that reduces performance Amiksin® average viral load against Epstein-Barr virus. Over the next 3 months follow-up, 25 % of patients the main group marked exacerbation study pathology of the upper respiratory tract, in the control group of patients with recurrent exacerbations were more - 60 %, indicating that preventive action Amiksin® therapy. Conclusions: The use of low-molecular interferon inductor Amiksin®(JSC “Pharmstandard-Tomskhimpharm”, Russia) in the combined therapy showed good efficacy in reducing the concentration of chronic viral infections in the oropharynx and prevention of chronic relapsing inflammatory diseases of the upper respiratory tract.
Mathematical models of the process of submlimationand optimization of lyophilization modes
Authors: Blynskaya E. V. , Tishkov S. V. , Alekseyev K. V. , Minaev S. V.
Published: November 2018

The purposeof this study is to analyze methods of mathematical modeling for calculating the stage of primary sublimation, as the most important stage in lyophilization technology. Presented are mathematical formulas, equations for the calculation of heat and mass transfer processes, during the removal of 90 % of all frozen ice. A model is considered that takes into account the contribution of all thermal effects, including the transient energy balance, taking into account the heat transfer through the side wall of the vial and radiation, even if they are present in a small amount. The mathematical model can be used to optimize the lyophilization cycle, and also as tools for technological monitoring (using sensors based on models). The model considered in the article is a one-dimensional nonstationary state model in which the correct comprehensive transient energy balance has been introduced to describe the heat transfer through the glass of the vial, and the results are estimated using experimental data. The equations used in the simulation describe the mass and energy balances in the dried layer, taking into account the rate of adsorption/desorption of water at the interface, mass and heat transfer at the sublimation interface, as well as the energy balance of heat transfer in the wall of vials, shelf and other factors affecting the process of sublimation. Conclusions are made on the presented mathematical models and the characteristic of the direction of the process of optimization of primary sublimation in lyophilization technology is given.
Effects of the cryolipolysis using the advanced redux method in the treatment of localized adiposity
Authors: Soares Roseane Débora Barbosa , Silva Rodrigo Marcel Valentim da , Silva Júlio Costa e , Pinto Bruna Figueiredo , Farias Stephan Queiroga , Farias Ana Lívia Eufrázio de Medeiros , Carreiro Eneida de Morais , Queiroz Claudete Arruda Maciel de , Meyer Patrícia Froes
Published: November 2018

Background: Among the techniques used in clinical practice to reduce localized adiposity, cryolipolysis has been highlighted, which is a non-invasive method capable of reducing the thickness of the adipose tissue without damage to the surrounding tissues. However, several associations of techniques suggest an intensification of the results, associating cryolipolysis with other treatments, and the most common is ultracavitation (UCV) or radiofrequency (RF) and massage. Objective: To investigate the effects of cryolipolysis associated with UCV and RF on localized adiposity. Methods: This is a blinded and controlled clinical trial. The sample was composed of 30 females divided into 2 groups of 15: one group received cryolipolysis application in the abdominal region, and performed 1 session of drainage weekly; while another group performed the cryolipolysis and then 8 applications of UCV associated with RF and modeling massage (protocol named Advanced Redux Method – ARM), once a week. The parameters used in cryolipolysis were: temperature: -7ºC; suction pressure: 30 kpa; and application time: 50 min. For the UCV, the parameters were time of 8 minutes, 30w of potency and intensity of 10 w/cm2 . After cryolipolysis, a follow-up of 2 months was performed to verify the changes related to weight, perimeter and thickness of the adipose tissue, measured by ultrasonography. The reassessments were performed 30 and 60 days after the cryolipolysis. Results: It was observed that the ARM promoted a greater reduction of adiposity located in the abdominal region, in the plicometry, perimetry and ultrasonography variables (p<0.05). In the analysis of the questionnaires the ARM group showed lower edema, pain, ecchymosis after application when compared to the group associated only with the drainage. The percentage of satisfaction was also higher in the ARM group. Conclusion: Therefore, it can be observed that the association of UCV, RF and modeling massage through the ARM promoted a higher reduction in adiposity than the group that exclusively performed the cryolipolysis treatment with lymphatic drainage.
Diez años de smartphones. Un análisis semiótico-comunicacional del impacto social de la telefonía móvil
Authors: Berlanga-Fernández Inmaculada , Gozalvez-Pérez Vicent , Renés Arellano Paula , Aguaded-Gómez Ignacio
Published: November 2018

El teléfono móvil con conexión a Internet (o smartphone) es la tecnología que más rápidamente se ha difundido en la sociedad actual y ha producido hábitos decisivos en los estilos de vida de la ciudadanía. Esta investigación examina desde una perspectiva semiótica-comunicacional la relación de diferentes sectores de la sociedad de hoy con estos dispositivos. Se sirve del universo narrativo del programa “Conectados” de la serie Salvados, programa dedicado precisamente al uso social de esta tecnología justo a los diez años de la aparición del primer smartphone. A través del análisis de los contenidos volcados por los diversos actores que intervienen –adolescentes, adultos, familias, escuela y expertos– se cuestiona si los nuevos dispositivos mediáticos nos empoderan o nos empobrecen y en qué medida lo hacen. La variedad de agentes que intervienen y, especialmente, la entrevista inédita al filósofo Bauman constituyen un amplio prisma social que da solidez a los resultados. Concluye reflexionando cuáles serían las condiciones para un uso autónomo, social, enriquecedor y crítico de tales dispositivos.
Abandono escolar y formación docente en Educación Secundaria
Authors: Santana-Hernández Rafael , Marchena-Gómez Rosa , Martín-Quintana Juan Carlos , Alemán-Falcón Jesús Ariel
Published: November 2018

El estudio se centró en averiguar las interpretaciones que elaboran diferentes agentes educativos de Educación Secundaria con respecto al abandono escolar temprano (AET) y la formación docente. Se adoptó para su desarrollo una perspectiva fenomenológica, seleccionado mediante muestreo intencional 54 centros. Se utilizó una entrevista semiestructurada cumplimentada por 51 orientadores, 95 profesores y 53 miembros de los equipos directivos, asi como diversos grupos de discusión en los que participaron 260 alumnos/as y 10 inspectores. Se realizó un análisis categorial utilizando el programa de Análisis Cualitativo de datos textuales (ATLAS.ti7), complementado con Microsoft Excel. Los resultados evidencian que, para la comunidad educativa analizada, el alumnado y su entorno familiar serían los factores que más incidirían en el AET. La formación docente no constituiría un elemento relevante, a pesar de las muchas investigaciones que argumentan lo contrario. Tampoco se considera clave a la hora de buscar estrategias favorecedoras de la continuidad escolar. Los hallazgos obtenidos permiten entender mejor cómo se organiza la institución escolar de Secundaria ante la realidad del AET, ayudando a establecer pautas de actuación para prevenirlo y aumentar la continuidad escolar.
Inclusión de personas con discapacidad auditiva en Educación Superior en Paraguay/Inclusion of people with hearing impairment within Paraguay’s Higher Education system
Authors: Gímenez Salvadora
Published: November 2018

El trabajo tiene como objetivo presentar la experiencia de implementación de la inclusión de personas con discapacidad auditiva en la Educación Superior en Paraguay, en tres universidades, dos públicas y una privada: Universidad Nacional de Asunción (UNA), Facultad de Filosofía; Universidad Nacional del Este (UNE), Facultad de Filosofía y Universidad Columbia del Paraguay. Este trabajo se complementa con entrevistas a algunos responsables de las instituciones de referencia. La experiencia se lleva a cabo en la carrera de Ciencias de la Educación en las universidades de Asunción y Ciudad del Este y en un módulo de la carrera de Diseño Gráfico en la Universidad Columbia, ubicada igualmente en la ciudad de Asunción. En todos los casos se realizan ajustes metodológicos que eliminen barreras y favorezcan la inclusión, contando para ello con intérpretes en lengua de señas. La experiencia se considera altamente positiva, si bien se constata la necesidad de contar con mayor formación del profesorado, con formación específica de los intérpretes en razón de la materia a interpretar, con incremento en la dotación de recursos tecnológicos y con material específico para un aprendizaje de calidad.
Glosa de Jorge Luis Borges (inspirada no perfil de “El atroz Redentor Lazarus Morell”)
Authors: Valadares Paulo
Published: November 2018

Este artigo busca construir, na forma de um comentário, uma genealogia judaica, estética e literária, de Jorge Luis Borges. A narração começa na Península Ibérica e retorna ao continente para lembrar o encontro do escritor argentino com o andaluz Rafael Cansinos-Asséns. Desse encontro, surge, na obra de Borges, um judaísmo estético, que irá estruturar seus textos mais importantes.
O estranho caso de Angélica, de Manoel de Oliveira: um viajar fora do tempo
Authors: Delgado Ana Maria dos Santos Silva
Published: November 2018

O filme O estranho caso de Angélica, de Manoel de Oliveira, lançado em 2010, remonta a um projeto de 1952 e sublinha a importância da memória na arte do cineasta. Entendendo memória como liberdade num “viajar fora do tempo”, a película reflete sobre a relação do cinema de Oliveira com outras artes visuais, nomeadamente a fotografia e o conceito de “aura”, como pensado por Walter Benjamin, além da pintura de Marc Chagall, em cuja obra se destacam quadros representando um casal a voar sobre a cidade. Analisaremos, assim, a relação do “viajar fora do tempo”, do filme, com o motivo da suspensão na obra do pintor judeu russo.
Tudo no mundo existe para terminar
Authors: Oliva Osmar Pereira
Published: November 2018

Tudo no mundo existe para terminar
Meus pés
Authors: Nascimento Lyslei
Published: November 2018

Meus pés
La traduzione delle espressioni deittiche
Authors: Urbaniak Ewa
Published: November 2018

Le espressioni deittiche sono tutte le unita linguistiche che indicano la localizzazione di un oggetto nello spazio e nel tempo. Ogni lingua si caratterizza per l’altra struttura deittica dipendente da vari fattori linguistici ed extralinguistici. L’analisi dei fattori che condizionano i sistemi deittici dell’italiano, dello spagnolo e del polacco dimostra vari problemi legati alla traduzione di questo tipo di costruzioni linguistiche e propone distinti modi di risolverli.
Environmental education between cultures and societies
Authors: Friman Hen , Sitbon Yafa , Banner Ifaa , Einav Yulia
Published: November 2018

Advances in elementary school curriculums supply theoretical lessons about environmental education; such an approach does not hold much information according to the topic, indicating that younger pupilsâ€™ level of knowledge is really depressed. In order to ensure effective environmental education, learning must be taught utilising a short piece of theoretical lesson that only offers the fundamentals and provides experiential experiments that illustrate scientific principles. Such activity gives even the weakest pupilsâ€™ the motivation to study the subject in a fun way and allows the pupilsâ€™ to learn at different levels thereby providing them with a practical and theoretical understanding of the material. Holon Institute of Technology (HIT) prides itself on its advanced academic achievements, application of innovative techniques that lead to creative teaching and new technologies. The students (Jews and Arabs) from HIT took part in action learning course that teaches environmental education by experience at Arab elementary school.Keywords: Environmental education, elementary school, Hebrew, Arabic.
Message from the Guest Editors
Authors: Matijevic Milan
Published: November 2018

It is the great honor for us to edit proceedings of Selected Paper of â€œ 7th International Conference on Education (IC-ED-2018), 28-30 June 2018, BAU International Berlin University of Applied Sciences, Berlin â€“ Germany. This privileged scientific event has contributed to the field of educational sciences and research for seven years.As the guest editor of this issue, I am glad to see variety of articles focusing on Curriculum and Instruction, Educational Technology, Educational Administration, Guiding and Counseling, Educational Planning ,Measurement and Evaluation in Education, Learning Psychology ,Developmental Psychology,Education and Culture ,Instructional Design, Learning and Teaching, Special Education, Distance Education, Life Long Learning, Mathematic Education, Social Sciences Teaching, Science Education, Language Learning and Teaching, Human Resources in Education, Teacher Training,Pre-school Education, Primary School Education, Secondary School Education, Vocational Education, College and Higher Education, Learner Needs in 21 Century, The Role of Education in the Globalization World,Human Rights Education ,Democracy Education, Innovation and Changing in Education ,New Learning Environments ,Environmental Education, Professional Development ,Creativity ,Nursery Education, Healthy Education ,Sport and Physical Education, Multi-cultural Education ,Mobile Learning, Technology-Based Learning, Music Education, Art Education, History Education, etc..Furthermore, the conference is getting more international each year, which is an indicator that it is getting worldwide known and recognized. Scholars from all over the world contributed to the conference. Special thanks are to all the reviewers, the members of the international editorial board, the publisher, and those involved in technical processes. We would like to thank all who contributed to in every process to make this issue actualized. A total of 50 full papers or abstracts were submitted for this conference and each paper has been peer reviewed by the reviewers specialized in the related field. At the end of the review process, a total of 18 high quality research papers were selected and accepted for publication.I hope that you will enjoy reading the papers.Best RegardsGuest EditorsProf. Dr. Milan Matijevic, University of Zagreb, CroatiaEditorial AssistantZeynep Genc, Msc. Near East University, North Cypr
Co-Construction Concept Through Cloud-Based Social Network Platform Design, Implementation, and Evaluation
Authors: Chang Ben , Shih Yen-An , Lu Fang-Chen
Published: November 2018

Today’s learners can easily share their thoughts on their social networks, and this movement, undoubtedly, has been affecting their learning. However, learners in such an ad hoc social network environment need a deliberate design to support their idea sharing and concept exchange. Gaining insights into how to stimulate concept sharing in a social network helps learners learn. To this end, this study examined how to design a cloud-based concept construction platform, and analyzed the users’ interaction behaviours on the platform. A cloud-based platform named CoCoing.info was implemented to achieve the aim. The platform has three major functions: (a) co-construction concept building, (b) social network organization, and (c) concept circulation among social networks. Seven hundred and twenty-six accounts registered on the platform. Users constructed 2,121 concepts using 20,049 nodes, and 1,618 files were established. The access statistics results indicated that the platform was used throughout the day, in which the ratio of in-class to after-class access was 0.59:0.41. Among the interactions, 31.24% belonged to concept construction and 68.76% were user responses. Meanwhile, the key player social networking analysis results indicated that teachers appear to play a crucial role in initiating concept construction and triggering social interaction within the type of concept construction social network.
PATRIOTIC EDUCATION OF YOUTH IN THE SOCIAL ORGANIZATION “DYNAMO”: HISTORY AND MODERNITY
Authors: BESKROVNAYA Olga Vasilevna , IVANNIKOV Sergey Viktorovich , NOVIKOV Sergey Vladimirovich
Published: November 2018

The activity of society “Dynamo” in historical and modern aspects in solving the problem of patriotic education of youth as one of the fundamental tasks of the modern Russian state is considered. It is shown that throughout the public organization “Dynamo” history through the active involvement of children to a healthy lifestyle forms the younger generation of an active life position, the desire for physical development, sports achievements for the glory of Russia. The essence of the organization society “Dynamo”, designed along with other tasks to strengthen the physical and spiritual health of Russian citizens of different age groups, using a variety of organizational forms and health-saving technologies is revealed. We show the aspect of coaching work with the younger generation, in which special attention is paid to the patriotic education of young people and teenagers seeking sports achievements. Within the modern structure of the society “Dynamo” the system and quality of sports training in its divisions are analyzed. Traditionally the results are checked in the course of numerous competitions. The importance of Spartakiads and competitions of “Dynamo” society in patriotic education of young people, which encourage the desire for health, strength, beauty, readiness to defend the sports honor of Russia in the athletes, is shown.
PECULIARITIES OF VARIABLE PROGRAMME ON THE “CREATIVE ABILITIES DEVELOPMENT” DISCIPLINE FOR MASTER’S DEGREE STUDENTS
Authors: SOROKINA Elena Vladimirovna
Published: November 2018

We prove the relevance and educational purposefulness of the “Creative Abilities Development” discipline for master’s degree students. We emphasize that there is constant social need in active and ambitious members of society, who are able to see new problematic areas, find new answers for non-standard questions, in other words, the society needs creative individuals. We consider the object, the tasks of the discipline and the demands of the study. The discipline gives a possibility to deepen the knowledge and form the competencies, which are defined by the content of basic disciplines; it also allows master’s degree students to gain skills for future successful pro-fessional and educational activities. We emphasize the special significance of individual work of master’s degree students during their studying. We suggest the following types of individual work: comprehension and assimilation of the lecture contents with a support on the educational and methodical literature recommended by the lecturer, use of information educational resources, preparation for practical classes, preparation of reports on the discipline, abstracts, essays, creation of the creative project, work with primary sources, visiting libraries, museums, exhibitions, concerts for the purpose of collecting and accumulation of information and broadening of horizons. We also emphasize the role of a lecturer in the organization of students’ cognitive activity. We prove that active development of cognitive activity of master’s degree students depends on the organization of non-traditional forms and methods of study: business and role play, training, discussions, implementation of information technologies, using pedagogical methods, which are adequate to the situation. Planning the content of “Creative Abilities Development” classes is possible due to integrative approach to the study, polyartistic development of master’s degree students.
PHYSIOLOGICAL ASPECTS OF PHYSICAL EDUCATION CLASSES WITH FIRST GRADERS WHO HAVE CARDIOVASCULAR SYSTEM DISEASE
Authors: ZAPOROZHTSEV Evgeniy Viktorovich , SELITRENIKOVA Tatyana Anatolevna
Published: November 2018

The analysis of the physiological aspects of conducting physical education classes with first graders who have cardiovascular disease is given. The research urgency is caused by the fact that recently the rate of child disability in Russia has doubled. Prevalent disabilities associated with cardiovascular diseases and their manifestations. The data analysis of morbidity and disability of children in Voronezh Region over the past five years is given, one could argue about the increase in the number of first-graders, divided in consequence to the special medical group and their reduction to the core. According to the Health Department of the Voronezh Region the highest prevalence of pathologies of the cardiovascular system in children of 7–8 years are cardiomyopathy and myocarditis various, as well as dysregulation of vascular tone, occurring in the form of neuro-circulatory dystonia. On average, pupils in the first grades of secondary institutions observed pathology of the cardiovascular system at 23.4 % of cases.We have developed a technique of physical training of correctional orientation for first graders having pathology of the cardiovascular system, including developing, gymnastic and breathing exercises that are adapted to individualisierung and dosing of the training load. The developed program allows to improve the process of physical education at physical culture lessons with first graders who have cardiovascular system disease.
On the Arrow of Spacetime
Authors: Harvey-Tremblay Alexandre
Published: November 2018

Consistent with special relativity and statistical physics, here we construct a partition function of space-time events. The union of these two theories resolves longstanding problems regarding time. We will argue that it augments the standard description of time given by the (non-relativistic) arrow of time to one able to describe the past, the present and the future in a manner consistent with our macroscopic experience of such. First, using Fermi-Dirac statistics, we find that the system essentially describes a "waterfall" of space-time events. This "waterfall" recedes in space-time at the speed of light towards the direction of the future as it "floods" local space with events that it depletes from the past. In this union, an observer $\mathcal{O}$ will perceive two horizons that can be interpreted as hiding events behind them. The first is an event horizon and its entropy hides events in the regions that $\mathcal{O}$ cannot see. The second is a time horizon, and its entropy "shields" events from $\mathcal{O}$'s causal influence. As only past events are "shielded" and not future events, an asymmetry in time is thus created. Finally, future events are hidden by an entropy prohibiting $\mathcal{O}$ from knowing the future before the present catches on.
Suppression of IFN-g Production in Murine Splenocytes by Histamine Receptor Antagonists
Authors: Kamei Miho , Otani Yukie , Hayashi Hidenori , Nakamura Tadaho , Yanai Kazuhiko , Furuta Kazuyuki , Tanaka Satoshi
Published: November 2018

Accumulating evidence suggests that histamine synthesis induced in several types of tumor tissues should modulate tumor immunity. We found that a transient histamine synthesis was induced in CD11b+Gr-1+splenocytes derived from BALB/c mice transplanted with a syngeneic colon carcinoma, CT-26, when they were co-cultured with CT-26 cells. Significant levels of IFN-γ were produced under this co-culture condition. We explored the modulatory roles of histamine on IFN-γ production and found that several histamine receptor antagonists, such as pyrilamine, diphenhydramine, JNJ7777120, and thioperamide, could significantly suppress IFN-γ production. However, suppression of IFN-γ production by these antagonists was also found when splenocytes were derived from the Hdc-/- BALB/c mice. Suppressive effects of these antagonists were found on IFN-γ production induced by concanavalin A or the combination of an anti-CD3 antibody and an anti-CD28 antibody in a histamine-independent manner. Murine splenocytes were found to express H1 and H2 receptors, but not H3 and H4 receptors. IFN-γ production in the Hh1r-/- splenocytes induced by the combination of an anti-CD3 antibody and an anti-CD28 antibody was significantly suppressed by these antagonists. These findings suggest that pyrilamine, diphenhydramine, JNJ7777120, and thioperamide could suppress IFN-γ production in activated splenocytes in histamine-independent manner.
Automated Recognition of Epileptic EEG States Using a Combination of Symlet Wavelet Processing, a Gradient Boosting Machine, and a Grid Search Optimizer
Authors: Wang Xiashuang , Gong Guanghong , Li Ni
Published: November 2018

Automatic recognition methods for non-stationary EEG data collected from EEG sensors play an essential role in neurological detection. The integrative approaches proposed in this study consists of Symlet wavelet processing, a gradient boosting machine, and a grid search optimizer for a three-level classification scheme for normal subjects, intermittent epilepsy, and continuous epilepsy. Fourth-order Symlet wavelets were adopted to decompose the EEG data into five time-frequency sub-bands, whose statistical features were computed and used as classification features. The grid search optimizer was used to automatically find the optimal parameters for training the classifier. The classification accuracy of the gradient boosting machine was compared with that of a support vector machine and a random forest classifier constructed according to previous descriptions. Multiple-index were used to evaluate the Symlet wavelet transform-gradient boosting machine-grid search optimizer classification scheme, which provided better classification accuracy and detection effectiveness than has recently reported in other work on three-level classification of EEG data.
­The Retinal Basis of Vertebrate Color Vision
Authors: Baden Tom , Osorio D.
Published: November 2018

Vertebrate color vision is evolutionarily ancient. Jawless fish evolved four main spectral types of cone photoreceptor, almost certainly complemented by retinal circuits to process chromatic opponent signals. Subsequent evolution of photoreceptors and visual pigments are now documented for many vertebrate lineages and species, giving insight into evolutionary variation and ecological adaptation of color vision. We look at organization of the photoreceptor mosaic and the functions different types of cone in teleost fish, primates, and birds and reptiles. By comparison less is known about the underlying neural processing. Here we outline the diversity of vertebrate color vision and summarize our understanding of how spectral information picked up by animal photoreceptor arrays is adapted to natural signals. We then turn to the question of how spectral information is processed in the retina. Here, the quite well known and comparatively ‘simple’ system of mammals such as mice and primates reveals some evolutionarily conserved features such as the mammalian BlueON system which compares short and long wavelength receptors signals. We then survey our current understanding of the more complex circuits of fish, amphibians, birds and reptiles. Together, these clades make up more than 90% of vertebrate species, yet we know disturbingly little about their neural circuits for colour vision beyond the photoreceptors. Here, long-standing work on goldfish, freshwater turtles and other species is being complemented by new insights gained from the experimentally amendable retina of zebrafish. From this body of work, one thing is clear: The retinal basis of colour vision in non-mammalian vertebrates is substantially richer compared to mammals: Diverse and complex spectral tunings are established at the level of the cone output via horizontal cell feedforward circuits. From here, zebrafish use cone-selective wiring in bipolar cells to set-up color opponent synaptic layers in the inner retina, which in turn lead a large diversity of color-opponent channels for transmission to the brain. However, while we are starting to build an understanding of the richness of spectral properties in some of these species’ retinal neurons, little is known about inner retinal connectivity and cell-type identify.  To gain an understanding of their actual circuits, and thus to build a more generalised understanding of the vertebrate retinal basis of color vision, it will be paramount to expand ongoing efforts in deciphering the retinal circuits of non-mammalian models.
Hybrid MAC Protocol for UAV-Assisted Wireless Sensor Networks
Authors: Ramli Muhammad Rusyadi , Kim Dong-Seong , Lee Jae Min
Published: November 2018

This paper proposes a hybrid medium access control (MAC) protocol for wireless sensor network (WSN) data gathering, employing unmanned aerial vehicles (UAV). The UAV sends a beacon frame periodically to inform sensor nodes regarding its presence. Afterward, each sensor node which receives beacon frame contends to send registration frame to the UAV. The UAV will transmit the second beacon frame to the registered nodes to notify their transmission schedule. The time-slot scheme is used for the transmission schedule. The transmission schedule of each sensor is determined based on their priority. Specifically, the priority of each sensor is determined during the registration process. Furthermore, the architecture of UAV-WSN data gathering system is introduced in this paper. Simulations are performed, showing that the proposed MAC protocol achieves fairness while enhancing network performance.
Sleep Disorders as a Mediator Between Socioeconomic Status and Health Outcomes: A Review of Differents Theories
Authors: Etindele Sosso Faustin Armel
Published: November 2018

The variations in the socioeconomic status between different social class of a population correspond to differences in accessibility to all resources available and able to improve global health. While socioeconomic status is now known as one of the main determinants for a good health and a good aging, its influence on sleep disorders is not well understood. The socioeconomic status is a concept, not directly observable but estimated using indicators like income, education, occupational status and area of living. This theoretical review explores some theories linking environment of people with occurrence of sleep disturbances, with different patterns associated to socioeconomic status. A model of interaction is proposed to summarize and conceptualizes these interactions and to promote more research on the topic.
Muller’s Ratchet and Ribosome Degeneration in the Obligate Intracellular Parasites Microsporidia
Authors: Melnikov Sergey , Manakongtreecheep Kasidet , Rivera Keith , Makarenko Arthur , Pappin Darryl , Söll Dieter
Published: November 2018

Microsporidia are fungi-like parasites that have the smallest known eukaryotic genome, and for that reason they are used as a model to study the phenomenon of genome decay in parasitic forms of life. Similar to other intracellular parasites that reproduce asexually in an environment with alleviated natural selection, Microsporidia experience continuous genome decay driven by Muller's ratchet - an evolutionary process of irreversible accumulation of deleterious mutations, which leads to gene loss and miniaturization of cellular components. Particularly, Microsporidia have remarkably small ribosomes in which the rRNA is reduced to the minimal enzymatic core. To better understand the impact of Muller's ratchet on RNA and protein molecules in parasitic organisms, particularly regarding their ribosome structure, we have explored an apparent effect of Muller's ratchet on microsporidian ribosomal proteins. Through mass spectrometry, analysis of microsporidian genome sequences and analysis of ribosome structure from non-parasitic eukaryotes, we found that massive rRNA reduction in microsporidian ribosomes appears to annihilate binding sites for ribosomal proteins eL8, eL27, and eS31, suggesting that these proteins are no longer bound to the ribosome in microsporidian species. We then provided an evidence that protein eS31 is retained in Microsporidia due to its non-ribosomal function in ubiquitin biogenesis. To sum up, our study illustrates that while Microsporidia carry the same set of ribosomal proteins as non-parasitic eukaryotes, some of ribosomal proteins are no longer participating in protein synthesis in Microsporidia and they are preserved from genome decay by having extra-ribosomal functions.
Deep Reinforcement Learning for Soft Robotic Applications: Brief Overview with Impending Challenges
Authors: Bhagat Sarthak , Banerjee Hritwick , Ren Hongliang
Published: November 2018

The increasing trend of studying the innate softness of robotic structures and amalgamating it with the benefits of the extensive developments in the field of embodied intelligence has led to sprouting of a relatively new yet extremely rewarding sphere of technology. The fusion of current deep reinforcement algorithms with physical advantages of a soft bio-inspired structure certainly directs us to a fruitful prospect of designing completely self-sufficient agents that are capable of learning from observations collected from their environment to achieve a task they have been assigned. For soft robotics structure possessing countless degrees of freedom, it is often not easy (something not even possible) to formulate mathematical constraints necessary for training a deep reinforcement learning (DRL) agent for the task in hand, hence, we resolve to imitation learning techniques due to ease of manually performing such tasks like manipulation that could be comfortably mimicked by our agent. Deploying current imitation learning algorithms on soft robotic systems have been observed to provide satisfactory results but there are still challenges in doing so. This review article thus posits an overview of various such algorithms along with instances of them being applied to real world scenarios and yielding state-of-the-art results followed by brief descriptions on various pristine branches of DRL research that may be centers of future research in this field of interest.
Strengthening Disaster Risk Governance to Manage Disaster Risk: Output of the Global Forum on Science and Technology for Disaster Resilience 2017
Authors: Tsukahara Kenichi ,   Disaster Risk Reduction Research Center, Graduate School of Engineering, Kyushu University 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan
Published: November 2018

The importance of disaster risk governance was stated in the Hyogo Framework for Action (HFA) in 2005. However, effective measures towards strengthening disaster risk governance from the science and technology community have not been sufficiently implemented since then. In the Sendai Framework for Disaster Risk Reduction (SFDRR) in 2015, “strengthening disaster risk governance to manage disaster risk” was established as one of the four action items, and many roles for the science and technology community were stated in the SFDRR. This report introduces the discussions and outcomes regarding the role of the science and technology community in strengthening disaster risk governance at the Global Forum on Science and Technology for Disaster Resilience 2017.
Investing in Disaster Risk Reduction for Resilience: Roles of Science, Technology, and Education
Authors: Kawasaki Akiyuki , Rhyner Jakob ,   Department of Civil Engineering, The University of Tokyo 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan,   United Nations University, Bonn, Germany
Published: November 2018

The Sendai Framework for Disaster Risk Reduction 2015–2030 established “Investing in Disaster Risk Reduction for Resilience” as Priority Action 3 with 17 actions in national and local levels and 9 actions in global and regional levels. So far, however, the budgets for disaster risk reduction are mainly used for post-disaster emergency response, recovery, and reconstruction in many countries. In the working sessions of Priority Action 3 of the Global Forum on Science and Technology for Disaster Resilience 2017, we discussed the actions that should be taken by the science, technology, and education sectors for an increase in proactive disaster risk reduction investment. This paper highlights the working group discussion, particularly focusing on the roles of science, technology, and education. Seven recommendations for promoting the implementation of the Priority Action 3 were adopted by the Forum as the final output from the working sessions of Priority Action 3.
SUBPRIME MORTGAGES AND LENDING BUBBLES
Authors: Polat Ali Yavuz
Published: November 2018

We consider a model with two types of households; the poor with no initial endowment and the rich with positive endowment; and two types of assets; properties in a poor area and properties in a rich area. In the model, poor agents need credit to buy an asset whereas the rich can draw from their endowment. We show that credit-fuelled housing bubbles sometimes may improve welfare, making the poorer individuals better-off. More precisely, there exist two types of equilibria in both markets: One is a bubble equilibrium, and the other is an equilibrium where asset prices are stable over time. While the poor always obtain a positive surplus in the bubble equilibrium, this is not necessarily true for the rich. Our results suggest that there may be scope for market interventions aimed at sustaining the value of assets held by credit-constrained agents after the burst of a credit bubble.
Well Reclassification Guidelines: The Backbone for Optimised Well Management at Country Level in Malaysia
Authors: Guillory Ryan , Wan Razali Wan Abdul , Masoudi Rahim , Ahmad Nur Asyikin , Hamid Azaruddin Azral
Published: November 2018

As host authority for all hydrocarbon resources in Malaysia, post 2016 transformation, the Malaysian Oil and Gas Regulator (PETRONAS MPM) put in place enhanced guidelines for classifying wells to steer Petroleum Arrangement Contractors (PAC's) to align with PETRONAS MPM Total Well Management Key Performance Indicators (KPI's) and aspirations. The well classification guidelines are key inputs to facilitate improvement by PAC's in enhancement of flowing strings and management of idle wells. Additionally, well classification was used in conjunction with new idle well time-bound guidelines to drive abandonment on idle wells with no remaining economic potential. Subsequent to roll-out of PETRONAS MPM enhanced guidelines for classifying wells and the added focus on well management, positive changes were observed in active string percentage (52% to 57%) and idle well management (~5% improvement in effective idle well restoration). The number of abandonment certificates increased from 20 wells to nearly 300 wells since the issuance of the new guidelines, and these wells are being planned for future abandonment with cost-effective and optimized scheduling at a national level.
Perforate Wash and Cement for Large Casing Sizes
Authors: Delabroy Laurent , Stokkeland Thore Andre , Åstrand Gustaf , Norum Espen
Published: November 2018

Perforate, Wash & Cement (PWC) is a method developed over the past few years to remediate cement behind casings, which has been widely applied to the Plugging and Abandoning (P&A) of wells. This technique can also be used to set permanent lateral barriers for slot recovery operations. However, the technique has been mostly applied to smaller casing sizes ranging from 7 – 10 ¾". In the growing slot recovery market across mature fields, the demand is increasing for a reliable and efficient method for achieving shallower lateral barriers, thus facilitating side tracks from bigger casing sizes such as 13 3/8" −13 5/8".

For the technology to be successful there are several components that need to be tailored for the specific casing size and borehole diameter. The optimal Tubing Conveyed Perforating (TCP) system needs to be in place to maximize efficiency for the washing and subsequent cementing operation. In order to reduce risk during the washing and cementing operation, it is critical that a suitable area of the wellbore is chosen for the remediation. This area is chosen based on the operational window for the Cup-type PWC technology where annular condition plays an important role. This paper describes the extensive work that has been performed to plan, execute and verify the placement of a lateral barrier across the 13 5/8" casing on the Valhall G-22 Well in the Norwegian continental shelf as part of the slot recovery program for the field.

The testing of the TCP Gun system resulted in an optimum Exit Hole Diameter (EHD) and geometry tailored to this specific application. An ultrasonic log was run prior to the PWC operation to determine the status of the annulus to be remediated. The optimal parameters for efficient cleaning of the annular space were simulated, and successfully achieved within the narrow Equivalent Circulating Density(ECD) window for the weak permeable zone below the perforated interval. The cement job was performed flawlessly with no losses, utilizing the Pump and Pull method with the Cup-type PWC system. Moreover, the actual job parameters matched very well with the simulations. The internal cement was drilled out and the annular cement was logged using an ultrasonic logging tool. The interpretation of the log showed perfect circumferential cement coverage across the entire remediated interval. With proper planning and optimized design and execution parameters, successful annular remediation can be achieved in large casing geometries using the PWC technique. This allows for more efficient and cost-effective slot recovery and P&A operations.
Laparoscopic versus open distal pancreatectomy (LAPOP), study protocol for a single center, non-blinded randomized controlled trial
Authors: Björnsson Bergthor , Sandström Per , Larsson Anna Lindhoff , Hjalmarsson Claes , Gasslander Thomas
Published: November 2018

Background: Earlier non-randomized studies have suggested that laparoscopic distal pancreatectomy (LDP) is advantageous in comparison to open distal pancreatectomy (ODP) regarding hospital stay, blood loss and recovery. Only one randomized study has been conducted showing reduced time to functional recovery after LDP compared to ODP.
Methods: LAPOP is a prospective randomized, non-blinded, parallel group single center superiority trial. Sixty patients with lesions in the pancreatic body or tail that are found by a multidisciplinary tumor board to need surgical resection will be randomized to LDP or ODP. The primary outcome variable is post-operative hospital stay and secondary outcomes include functional recovery (defined as no need for intravenous medications or fluids as well as ambulatory patient able to perform activities of daily live), perioperative bleeding, complications, need of pain medication and quality of life comparison.
Discussion: The LAPOP trial will test the hypothesis that LDP reduces post-operative hospital stay compared to ODP