bluuebunny/crossref_metadata_2025 huggingface dataset:
Concepts of Interpolation in Stratified Institutions
Authors: Diaconescu Răzvan
Published: April 2023

The extension of the (ordinary) institution theory of Goguen and Burstall, known as the theory of stratified institutions, is a general axiomatic approach to model theories where the satisfaction is parameterized by states of models. Stratified institutions cover a uniformly wide range of applications from various Kripke semantics to various automata theories and even model theories with partial signature morphisms. In this paper, we introduce two natural concepts of logical interpolation at the abstract level of stratified institutions and we provide some sufficient technical conditions in order to establish a causality relationship between them. In essence, these conditions amount to the existence of nominals structures, which are considered fully and abstractly.
2-(3-Bromophenyl)imidazo[2,1-b]oxazole
Authors: Cores Ángel , Villacampa Mercedes , Menéndez J. Carlos
Published: April 2023

The microwave-assisted reaction of 2-nitroimidazole with 3-bromophenacyl bromide in the presence of potassium carbonate as a base and dimethylformamide as a solvent afforded 2-(3-bromophenyl)imidazo[2,1-b]oxazole. The formation of this compound was explained via a domino mechanism comprising an initial N-alkylation reaction of the imidazole substrate, followed by the base-promoted deprotonation of the position adjacent to the carbonyl to give an enolate anion that finally cyclizes via an intramolecular SNAr reaction, with the loss of the nitro group as potassium nitrite. Then, the proposed 1-(3-bromophenacyl)-2-nitroimidazole intermediate could be isolated by reducing the reaction time and was shown to be a precursor of the imidazo[2,1-b]oxazole final product.
Effect of TiB2 Nanoparticle Content on the Microstructure and Mechanical Properties of TiB2/Mg-4Al-1.5Si Composites
Authors: Liu Jian , Chen Xiaogang , Wang Wuxiao , Zhao Yu , He Na
Published: April 2023

Coarse primary and eutectic Mg2Si phases were generally precipitated in Mg-Al-Si alloys during solidification at a low cooling rate, which tends to deteriorate the strength and ductility of magnesium alloys due to stress concentration. Different volume fractions of TiB2 nanoparticles (1%, 3%, and 5%) were added to an Mg-4Al-1.5Si alloy to refine the coarse Mg2Si phases based on a heterogeneous nucleation mechanism. The nanoparticles were incorporated and dispersed in the molten Mg alloys and by using semi-solid stirring followed by ultrasonic treatment (SSUT), and TiB2/Mg-4Al-1.5Si composites were obtained. The effect of TiB2 content on the microstructure and mechanical properties of the composites was studied. The results showed that the average size of primary Mg2Si phases and α-Mg grains decreased as the TiB2 content raised, the dendritic primary Mg2Si phases were refined into polygonal shapes with smaller sizes, and the refined primary Mg2Si phases were uniformly distributed in the alloys after adding 1 vol.% or 3 vol.% TiB2 nanoparticles. As the TiB2 content increased, the morphology of the eutectic Mg2Si phases was modified from coarse Chinese characters to short rod or fine dot shapes. Vickers hardness and yield strength of the composites reached a maximum (153 HV and 90.9 MPa, respectively) when TiB2 content was 5 vol.%, while the most superior ultimate tensile strength (142.4 MPa) and elongation (9.2%) were obtained when TiB2 content was 3 vol.%, which were improved by 173.2%, 31.5%, 69.8%, and 187.5%, respectively compared with the Mg-4Al-1.5Si alloys.
The New Technology of Die Forging of Automotive Connecting Rods from EN AB-71100 Aluminium Alloy Cast Preforms
Authors: Dziubinska Anna
Published: April 2023

This article presents a new technology for forming automotive connecting rod forgings by means of die forging from cast performs from EN AB-71100 (EN AB-AlZn10Si8Mg) aluminum alloy. A premise was made that the production process would be carried out on forging presses. The process of forming connecting rod forgings was analyzed considering different deformation rates related to the type of machine used: a crank press and a screw press. The billet in the form of in-house designed, shaped preforms cast into sand molds with two variants of geometry was used in the process. The numerical analysis of the new process was carried out on the basis of the finite element method using Deform 3D, the simulation software for metal forming. The simulations were conducted in the spatial deformation conditions, considering the full thermomechanical analysis. Based on the simulations, certain important findings concerning the novel process were acquired, including the distribution of stress, deformation, temperatures, cracking criterion and energy parameters. The results of numerical tests confirmed the possibility of producing defect-free forgings of connecting rods from EN AB-71100 aluminum alloy on forging presses by means of the proposed technology. The proposed process of forging using crank and screw presses was verified in the course of tests conducted in industrial conditions. The properly formed connecting rod forgings were subjected to quality tests in terms of their structure and mechanical properties.
The Studies on Chitosan for Sustainable Development: A Bibliometric Analysis
Authors: Lam Weng Siew , Lam Weng Hoe , Lee Pei Fun
Published: April 2023

Chitosan is a biocompatible polymer with vast applications in pharmacology, medicine, paper making, agriculture, and the food industry due to its low toxicity. Chitosan also plays an important role in the sustainable environment since chitosan is able to absorb greenhouse gases, harmful organic matter, and heavy ions. Therefore, this paper conducts a bibliometric analysis of chitosan for sustainable development using the Scopus database from 1976 to 2023. A performance analysis on the 8002 documents was performed with Harzing’s Publish or Perish. Science mapping was conducted using VOSviewer. The annual publication on chitosan for sustainable development showed an upward trend in recent years as the annual publication peaked in 2022 with 1178 documents with most of the documents being articles and published in journals. Material science, chemistry, and engineering are tightly related subject areas. China had the highest publication of 1560 total documents while the United States had the most impactful publication with 55,019 total citations, 68.77 citations per document, 77.6 citations per cited document, h-index 110, and g-index of 211. India had the largest international collaboration with 572 total link strength. “International Journal of Biological Macromolecules”, “Carbohydrate Polymers”, and “Polymers” have been identified as the top three source titles that publish the most documents on chitosan for sustainable development. The emerging trends in chitosan on sustainable development focus on the application of chitosan as an antibacterial agent and biosorbent for contaminants, especially in water treatment.
Microstructures, Mechanical Properties and Electromagnetic Wave Absorption Performance of Porous SiC Ceramics by Direct Foaming Combined with Direct-Ink-Writing-Based 3D Printing
Authors: Wu Jianqin , Zhang Lu , Wang Wenqing , Su Ruyue , Gao Xiong , Li Suwen , Wang Gang , He Rujie
Published: April 2023

Direct-ink-writing (DIW)-based 3D-printing technology combined with the direct-foaming method provides a new strategy for the fabrication of porous materials. We herein report a novel method of preparing porous SiC ceramics using the DIW process and investigate their mechanical and wave absorption properties. We investigated the effects of nozzle diameter on the macroscopic shape and microstructure of the DIW SiC green bodies. Subsequently, the influences of the sintering temperature on the mechanical properties and electromagnetic (EM) wave absorption performance of the final porous SiC-sintered ceramics were also studied. The results showed that the nozzle diameter played an important role in maintaining the structure of the SiC green part. The printed products contained large amounts of closed pores with diameters of approximately 100–200 μm. As the sintering temperature increased, the porosity of porous SiC-sintered ceramics decreased while the compressive strength increased. The maximum open porosity and compressive strength were 65.4% and 7.9 MPa, respectively. The minimum reflection loss (RL) was −48.9 dB, and the maximum effective absorption bandwidth (EAB) value was 3.7 GHz. Notably, porous SiC ceramics after sintering at 1650 °C could meet the application requirements with a compressive strength of 7.9 MPa, a minimum RL of −27.1 dB, and an EAB value of 3.4 GHz. This study demonstrated the potential of direct foaming combined with DIW-based 3D printing to prepare porous SiC ceramics for high strength and excellent EM wave absorption applications.
Negative Magnetoresistance in Hopping Regime of Lightly Doped Thermoelectric SnSe
Authors: Zorić Marija , Dhami Naveen Singh , Bader Kristian , Gille Peter , Smontara Ana , Popčević Petar
Published: April 2023

Semiconducting SnSe, an analog of black phosphorus, recently attracted great scientific interest due to a disputed report of a large thermoelectric figure of merit, which has not been reproduced subsequently. Here we concentrate on the low-temperature ground state. To gain a better understanding of the system, we present magneto-transport properties in high-quality single crystals of as-grown, lightly doped SnSe down to liquid helium temperatures. We show that SnSe behaves as a p-type doped semiconductor in the vicinity of a metal-insulator transition. Electronic transport at the lowest temperatures is dominated by the hopping mechanism. Negative magnetoresistance at low fields is well described by antilocalization, while positive magnetoresistance at higher fields is consistent with the shrinkage of localized impurity wavefunctions. At higher temperatures, a dilute metallic regime is realized where elusive T2 and B2 resistivity dependence is observed, posing a challenge to theoretical comprehension of the underlying physical mechanism.
Photoacoustic Characterization of TiO2 Thin-Films Deposited on Silicon Substrate Using Neural Networks
Authors: Djordjević Katarina Lj , Markushev Dragana K. , Popović Marica N. , Nesić Mioljub V. , Galović Slobodanka P. , Lukić Dragan V. , Markushev Dragan D.
Published: April 2023

In this paper, the possibility of determining the thermal, elastic and geometric characteristics of a thin TiO2 film deposited on a silicon substrate, with a thickness of 30 μm, in the frequency range of 20 to 20 kHz with neural networks were analysed. For this purpose, the geometric (thickness), thermal (thermal diffusivity, coefficient of linear expansion) and electronic parameters of substrates were known and constant in the two-layer model, while the following nano-layer thin-film parameters were changed: thickness, expansion and thermal diffusivity. Predictions of these three parameters of the thin-film were analysed separately with three neural networks. All of them together were joined by a fourth neural network. It was shown that the neural network, which analysed all three parameters at the same time, achieved the highest accuracy, so the use of networks that provide predictions for only one parameter is less reliable. The obtained results showed that the application of neural networks in determining the thermoelastic properties of a thin film on a supporting substrate enables the estimation of its characteristics with great accuracy.
Structural Characterization and Anti-Inflammatory Effects of 24-Methylcholesta-5(6), 22-Diene-3β-ol from the Cultured Marine Diatom Phaeodactylum tricornutum; Attenuate Inflammatory Signaling Pathways
Authors: Samarakoon Kalpa W. , Kuruppu Anchala I. , Ko Ju-Young , Lee Ji-Hyeok , Jeon You-Jin
Published: April 2023

In the present investigation, 24-methylcholesta-5(6), 22-diene-3β-ol (MCDO), a major phytosterol was isolated from the cultured marine diatom, Phaeodactylum tricornutum Bohlin, and in vitro and in vivo anti-inflammatory effects were determined. MCDO demonstrated very potent dose-dependent inhibitory effects on the production of nitric oxide (NO) and prostaglandin E2 (PGE2) against lipopolysaccharide (LPS)-induced RAW 264.7 cells with minimal cytotoxic effects. MCDO also demonstrated a strong and significant suppression of pro-inflammatory cytokines of interleukin-1β (IL-1β) production, but no substantial inhibitory effects were observed on the production of cytokines, including tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) at the tested concentrations against LPS treatment on RAW macrophages. Western blot assay confirmed the suppression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein expressions against LPS-stimulated RAW 264.7 cells. In addition, MCDO was assessed for in vivo anti-inflammatory effects using the zebrafish model. MCDO acted as a potent inhibitor for reactive oxygen species (ROS) and NO levels with a protective effect against the oxidative stress induced by LPS in inflammatory zebrafish embryos. Collectively, MCDO isolated from the cultured marine diatom P. tricornutum exhibited profound anti-inflammatory effects both in vitro and in vivo, suggesting that this major sterol might be a potential treatment for inflammatory diseases.
Multifractal Analysis of the Influence of Indole-3-Acetic Acid on Fast-Activating Vacuolar (FV) Channels of Beta vulgaris L. Taproot Cells
Authors: Miśkiewicz Janusz , Burdach Zbigniew , Trela Zenon , Siemieniuk Agnieszka , Karcz Waldemar
Published: April 2023

In this paper, the multifractal properties of the ion current time series in the fast-activating vacuolar (FV) channels of Beta vulgaris L. taproot cells were investigated. These channels are permeable for only monovalent cations and mediate K+ at very low concentrations of cytosolic Ca2+ and large voltages of either polarity. Using the patch clamp technique, the currents of the FV channels in red beet taproot vacuoles were recorded and analysed by using the multifractal detrended fluctuation analysis (MFDFA) method. The activity of the FV channels depended on the external potential and was sensitive to the auxin. It was also shown that the singularity spectrum of the ion current in the FV channels is non-singular, and the multifractal parameters, i.e., the generalised Hurst exponent and the singularity spectrum, were modified in the presence of IAA. Taking into account the obtained results, it can be suggested that the multifractal properties of fast-activating vacuolar (FV) K+ channels, indicating the existence of long-term memory, should be taken into account in the molecular mechanism of the auxin-induced growth of plant cells.
Three-Dimension Crack Propagation Behavior of Conical-Cylindrical Shell
Authors: Zhu Yongmei , Yang Jiahao , Pan Hongzhang
Published: April 2023

The conical-cylindrical shell is prone to stress concentration in the convex cone position under the action of deep-sea pressures. This results in unidirectional or bidirectional positive tensile stresses on the surfaces of the shell. The conical-cylindrical shell is a large, welded structure. Welding residual stress was generated at the cone-column joint position, resulting in high-stress concentration at this location. Under both the residual stress of welding and seawater pressure, cracks easily form and propagate on the shell weld toe, leading to fatigue damage and even structural failure. In this paper, based on the seawater’s alternating load and the residual stress of welding, the three-dimensional crack propagation process was studied for the submarine conical-cylindrical shell. The effects of crack depth and shape ratio on crack propagation trend and fatigue life were analyzed. The results can provide references for predicting the crack propagation trend, assessing the remaining life and evaluating the structural safety of the submarine conical-cylindrical shell.
Demographic, Health and Lifestyle Factors Associated with the Metabolome in Older Women
Authors: Navarro Sandi L. , Nagana Gowda G. A. , Bettcher Lisa F. , Pepin Robert , Nguyen Natalie , Ellenberger Mathew , Zheng Cheng , Tinker Lesley F. , Prentice Ross L. , Huang Ying , Yang Tao , Tabung Fred K. , Chan Queenie , Loo Ruey Leng , Liu Simin , Wactawski-Wende Jean , Lampe Johanna W. , Neuhouser Marian L. , Raftery Daniel
Published: April 2023

Demographic and clinical factors influence the metabolome. The discovery and validation of disease biomarkers are often challenged by potential confounding effects from such factors. To address this challenge, we investigated the magnitude of the correlation between serum and urine metabolites and demographic and clinical parameters in a well-characterized observational cohort of 444 post-menopausal women participating in the Women’s Health Initiative (WHI). Using LC-MS and lipidomics, we measured 157 aqueous metabolites and 756 lipid species across 13 lipid classes in serum, along with 195 metabolites detected by GC-MS and NMR in urine and evaluated their correlations with 29 potential disease risk factors, including demographic, dietary and lifestyle factors, and medication use. After controlling for multiple testing (FDR < 0.01), we found that log-transformed metabolites were mainly associated with age, BMI, alcohol intake, race, sample storage time (urine only), and dietary supplement use. Statistically significant correlations were in the absolute range of 0.2–0.6, with the majority falling below 0.4. Incorporation of important potential confounding factors in metabolite and disease association analyses may lead to improved statistical power as well as reduced false discovery rates in a variety of data analysis settings.
Effect of Cigarette Smoke Exposure and Aspirin Treatment on Neurotransmitters’ Tissue Content in Rats’ Hippocampus and Amygdala
Authors: Hammad Alaa M. , Alhusban Ala A. , Alzaghari Lujain F. , Alasmari Fawaz , Sari Youssef
Published: April 2023

Cigarette smoke withdrawal can cause anxiety-like behavior and modulate neurotransmitter-related proteins in the brain. We examined the effects of cigarette smoke with and without aspirin treatment on the concentrations of neurotransmitters, including dopamine, serotonin, glutamate, glutamine, and GABA in the amygdala and hippocampus. Sprague-Dawley rats were randomly assigned to four different groups: (1) control group exposed only to standard room air, (2) cigarette smoke exposed group treated with saline vehicle, (3) cigarette smoke exposed group treated with aspirin (30 mg/kg), and (4) control group treated only with aspirin (30 mg/kg). Cigarette smoke exposure was performed for 2 h/day, 5 days/week, for 31 days. Behavioral testing was carried out weekly, 24 h after cigarette smoke exposure, during acute withdrawal. At the end of week 4, rats were given either distilled water (1 mL) or aspirin 45 min before cigarette exposure for 11 days. Dopamine, serotonin, glutamate, glutamine, and GABA were extracted from both the amygdala and hippocampus and were separated and quantified using a developed and validated HPLC-MS/MS method. Cigarette smoke withdrawal induced anxiety behaviors, and aspirin treatment reduced this effect. Cigarette smoke exposure increased tissue content of dopamine, serotonin, glutamate, glutamine, and GABA, and aspirin treatment reversed this effect. Cigarette smoke caused an increase in tissue content of several neurotransmitters as well as anxiety-like behavior, and these effects were normalized by aspirin treatment.
Digitally Based Precision Time-Domain Spectrometer for NMR Relaxation and NMR Cryoporometry
Authors: Webber John Beausire Wyatt , Demin Pavel
Published: April 2023

NMR Relaxation (NMRR) is an extremely useful quantitative technique for material science, particularly for studying polymers and porous materials. NMR Cryoporometry (NMRC) is a powerful technique for the measurement of pore-size distributions and total porosities. This paper discusses the use, capabilities and application of a newly developed compact NMR time-domain relaxation spectrometer suitable for studying both solid and liquid samples (Mk3 NMR Relaxation spectrometer & Cryoporometer, Lab-Tools (nano-science), Ramsgate, Kent, UK. (2019)). This highly compact precision NMR Spectrometer is based on a Field Programmable Gate array (FPGA) module and custom surface mount low-noise NMR receiver and NMR linear transmitter. A high proportion of the RF circuitry is in a digital form, implemented as firmware in the FPGA, which gives the instrument an excellent long-term stability. It also includes an on-chip Linux computer. The FPGA module is credit-card sized, and both the NMR receiver and NMR transmitter are even smaller. The software, including the top-level NMR pulse sequence definitions, are written in an array processing language, Apl. The spectrometer comes complete with a Graphical User Interface (GUI) for control and on- and offline curve fitting and data analysis. The recent development of the Lab-Tools Peltier thermo-electrically cooled NMR variable-temperature (V-T) probe that cools the sample below −60 °C is also discussed. This Peltier cooling gives the precision temperature control and smoothness needed by NMR Cryoporometry (10 mK near the probe liquid bulk melting point). This enables the NMRC measurement of pore-size distributions in porous materials, for the unusually wide pore-size range of sub-nano to over 1 micron-sized pores. The NMR Spectrometer’s unusually small size, ability to measure solids, low noise and high performance make it particularly suitable for material science studies both in the field and in university, research institute, company and even school laboratories. A human portable version now exists. Use of the controlling GUI is described, and results from example NMR Relaxation and NMR Cryoporometric measurements are given.
Study on Partial Replacement of Metal Grinding Ball with Pebbles When Grinding Itabirite Ores
Authors: Sanches Júlia Guimarães , Bergerman Mauricio Guimarães , Delboni Homero , Lima Neymayer
Published: April 2023

Grinding iron ores in conventional ball mills involve a considerably high consumption of metallic media, resulting in high operating costs. In the case of compact itabirites, the high silica content increases such consumption, potentially exceeding the costs associated with electric power consumption in industrial operations. This paper presents research conducted to assess the use of compact itabirite samples obtained from an industrial crushing plant as grinding media to assist conventional ball grinding in the same installation. In this case, the mill charge included both coarse ore fragments and steel balls. Two ore samples were characterized, and bench-scale grinding tests were carried out in laboratory mills 30 and 58 cm in diameter. The results indicated that coarse compact itabirite ore (pebbles) can be used as grinding media. Grinding tests have shown that replacing 25% of the steel balls with pebbles offered promising results. Their use as mixed grinding media results in a relatively minor increase in power consumption and low pebble wear.
Scutellarin Alleviates Ischemic Brain Injury in the Acute Phase by Affecting the Activity of Neurotransmitters in Neurons
Authors: Wang Chunguo , Liu Yaoyu , Liu Xi , Zhang Yuting , Yan Xingli , Deng Xinqi , Shi Jinli
Published: April 2023

Cerebral ischemic stroke is a common neuron loss disease that is caused by the interruption of the blood supply to the brain. In order to enhance the CIS outcome, both identifying the treatment target of ischemic brain damage in the acute phase and developing effective therapies are urgently needed. Scutellarin had been found to be beneficial to ischemic injuries and has been shown to have potent effects in clinical application on both stroke and myocardial infarction. However, whether scutellarin improves ischemic brain damage in the acute phase remains unknown. In this study, the protective effects of scutellarin on ischemic brain damage in the acute phase (within 12 h) were illustrated. In middle cerebral artery occlusion and reperfusion (MCAO/R) modeling rats, the Z-Longa score was significantly down-regulated by 25% and 23.1%, and the brain infarct size was reduced by 26.95 ± 0.03% and 25.63 ± 0.02% when responding to high-dose and low-dose scutellarin treatments, respectively. H&E and TUNEL staining results indicated that the neuron loss of the ischemic region was improved under scutellarin treatment. In order to investigate the mechanism of scutellarin’s effects on ischemic brain damage in the acute phase, changes in proteins and metabolites were analyzed. The suppression of scutellarin on the glutamate-inducing excitatory amino acid toxicity was strongly indicated in the study of both proteomics and metabolomics. A molecular docking experiment presented strong interactions between scutellarin and glutamate receptors, which score much higher than those of memantine. Further, by performing a parallel reaction monitoring-mass spectrometry (PRM-MS) study on both the cortex and hippocampus tissue of the ischemic region, we screened the scutellarin-regulating molecules that are involved in both the release and transportation of neurotransmitters. It was found that the aberrant levels of glutamate receptors, including EAAT2, GRIN1, GRIN2B, and GRM1, as well as of other glutamatergic pathway-involving proteins, including CAMKK2, PSD95, and nNOS, were significantly regulated in the ischemic cortex. In the hippocampus, EAAT2, GRIN1, nNOS, and CAM were significantly regulated. Taken together, scutellarin exerts potent effects on ischemic brain damage in the acute phase by regulating the activity of neurotransmitters and reducing the toxicity of excitatory amino acids in in neurons.
Preparation of Biochar with Developed Mesoporous Structure from Poplar Leaf Activated by KHCO3 and Its Efficient Adsorption of Oxytetracycline Hydrochloride
Authors: Wei Zhenhua , Hou Chao , Gao Zhishuo , Wang Luolin , Yang Chuansheng , Li Yudong , Liu Kun , Sun Yongbin
Published: April 2023

The effective removal of oxytetracycline hydrochloride (OTC) from the water environment is of great importance. Adsorption as a simple, stable, and cost-effective technology is regarded as an important method for removing OTC. Herein, a low-cost biochar with a developed mesoporous structure was synthesized via pyrolysis of poplar leaf with potassium bicarbonate (KHCO3) as the activator. KHCO3 can endow biochar with abundant mesopores, but excessive KHCO3 cannot continuously promote the formation of mesoporous structures. In comparison with all of the prepared biochars, PKC-4 (biochar with a poplar leaf to KHCO3 mass ratio of 5:4) shows the highest adsorption performance for OTC as it has the largest surface area and richest mesoporous structure. The pseudo-second-order kinetic model and the Freundlich equilibrium model are more consistent with the experimental data, which implies that the adsorption process is multi-mechanism and multi-layered. In addition, the maximum adsorption capacities of biochar are slightly affected by pH changes, different metal ions, and different water matrices. Moreover, the biochar can be regenerated by pyrolysis, and its adsorption capacity only decreases by approximately 6% after four cycles. The adsorption of biochar for OTC is mainly controlled by pore filling, though electrostatic interactions, hydrogen bonding, and π-π interaction are also involved. This study realizes biomass waste recycling and highlights the potential of poplar leaf-based biochar for the adsorption of antibiotics.
The Synthesis and Biological Applications of the 1,2,3-Dithiazole Scaffold
Authors: Kalogirou Andreas S. , Oh Hans J. , Asquith Christopher R. M.
Published: April 2023

The 1,2,3-dithiazole is an underappreciated scaffold in medicinal chemistry despite possessing a wide variety of nascent pharmacological activities. The scaffold has a potential wealth of opportunities within these activities and further afield. The 1,2,3-dithiazole scaffold has already been reported as an antifungal, herbicide, antibacterial, anticancer agent, antiviral, antifibrotic, and is a melanin and Arabidopsis gibberellin 2-oxidase inhibitor. These structure activity relationships are discussed in detail, along with insights and future directions. The review also highlights selected synthetic strategies developed towards the 1,2,3-dithiazole scaffold, how these are integrated to accessibility of chemical space, and to the prism of current and future biological activities.
Encapsulation of Ammoides pusila Essential Oil into Mesoporous Silica Particles for the Enhancement of Their Activity against Fusarium avenaceum and Its Enniatins Production
Authors: Chakroun Yasmine , Snoussi Youssef , Chehimi Mohamed M. , Abderrabba Manef , Savoie Jean-Michel , Oueslati Souheib
Published: April 2023

Essential oils (EOs) that have antifungal activity and mycotoxin reduction ability are candidates to develop bioactive alternatives and environmentally friendly treatment against Fusarium species in cereals. However, their practical use is facing limitations such as high volatility, UV sensitivity, and fast oxidation. Encapsulation techniques are supposed to provide protection to the EOs and control their release into the environment. Ammoides pusilla essential oil (AP-EO) proved to be an efficient inhibitor of Fusarium avenaceum growth and its enniatins (ENNs) production. In the present work, AP-EO was encapsulated, using the impregnation method, into mesoporous silica particles (MSPs) with narrow slit pores (average diameter = 3.1 nm) and coated with chitosan. In contact assays using an agar medium, the antifungal activity of AP-EO at 0.1 µL mL−1 improved by three times when encapsulated into MSPs without chitosan and the ENNs production was significantly inhibited both in coated and non-coated MSPs. Controls of MSPs also inhibited the ENNs production without affecting the mycelial growth. In fumigation experiments assessing the activity of the EO volatile compounds, encapsulation into MSPs improved significantly both the antifungal activity and ENNs inhibition. Moreover, coating with chitosan stopped the release of EO. Thus, encapsulation of an EO into MSPs improving its antifungal and antimycotoxin properties is a promising tool for the formulation of a natural fungicide that could be used in the agriculture or food industry to protect plant or food products from the contamination by toxigenic fungi such as Fusarium sp. and their potential mycotoxins.
g-C3N4 Based Photocatalyst for the Efficient Photodegradation of Toxic Methyl Orange Dye: Recent Modifications and Future Perspectives
Authors: Aljuaid Abdulelah , Almehmadi Mazen , Alsaiari Ahad Amer , Allahyani Mamdouh , Abdulaziz Osama , Alsharif Abdulaziz , Alsaiari Jawaher Amer , Saih Magdi , Alotaibi Rema Turki , Khan Idrees
Published: April 2023

Industrial effluents containing dyes are the dominant pollutants, making the drinking water unfit. Among the dyes, methylene orange (MO) dye is mutagenic, carcinogenic and toxic to aquatic organisms. Therefore, its removal from water bodies through effective and economical approach is gaining increased attention in the last decades. Photocatalytic degradation has the ability to convert economically complex dye molecules into non-toxic and smaller species via redox reactions, by using photocatalysts. g-C3N4 is a metal-free n-type semiconductor, typical nonmetallic and non-toxici polymeric photocatalyst. It widely used in photocatalytic materials, due to its easy and simple synthesis, fascinating electronic band structure, high stability and abundant availability. As a photocatalyst, its major drawbacks are its limited efficiency in separating photo-excited electron–hole pairs, high separated charge recombination, low specific surface area, and low absorption coefficient. In this review, we report the recent modification strategies adopted for g-C3N4 for the efficient photodegradation of MO dye. The different modification approaches, such as nanocomposites and heterojunctions, as well as doping and defect introductions, are briefly discussed. The mechanism of the photodegradation of MO dye by g-C3N4 and future perspectives are discussed. This review paper will predict strategies for the fabrication of an efficient g-C3N4-based photocatalyst for the photodegradation of MO dye.
Study on the Hydration of α-Pinene Catalyzed by α-Hydroxycarboxylic Acid–Boric Acid Composite Catalysts
Authors: Meng Zhonglei , Qin Rongxiu , Wen Rusi , Li Guiqing , Liang Zhongyun , Xie Junkang , Yang Zhangqi , Zhou Yonghong
Published: April 2023

In this study, seven types of α-hydroxycarboxylic acids were selected to form composite catalysts with boric acid, and their catalytic properties were studied using the catalytic hydration of α-pinene. The results showed that the composite catalyst of boric acid and tartaric acid had the highest catalytic activity. With an α-pinene, water, acetic acid, tartaric acid, and boric acid mass ratio of 10:10:25:0.5:0.4, the reaction temperature was 60 °C, the reaction time was 24 h, the conversion of α-pinene was 96.1%, and the selectivity of terpineol was 58.7%. The composite catalyst composed of boric acid and mandelic acid directly catalyzed the hydration of α-pinene in the absence of a solvent. Under the optimal conditions, the conversion of α-pinene reached 96.1%, and the selectivity of terpineol was 55.5%. When the composite catalyst catalyzed α-pinene to synthesize terpineol in one step, the terpineol was optically active, and terpineol synthesized using the two-step method with the dehydration of p-menthane-1,8-diol monohydrate was racemic. These composite catalysts may offer good application prospects in the synthesis of terpineol.
Relationship between Protein Digestibility and the Proteolysis of Legume Proteins during Seed Germination
Authors: Bera Indrani , O’Sullivan Michael , Flynn Darragh , Shields Denis C.
Published: April 2023

Legume seed protein is an important source of nutrition, but generally it is less digestible than animal protein. Poor protein digestibility in legume seeds and seedlings may partly reflect defenses against herbivores. Protein changes during germination typically increase proteolysis and digestibility, by lowering the levels of anti-nutrient protease inhibitors, activating proteases, and breaking down storage proteins (including allergens). Germinating legume sprouts also show striking increases in free amino acids (especially asparagine), but their roles in host defense or other processes are not known. While the net effect of germination is generally to increase the digestibility of legume seed proteins, the extent of improvement in digestibility is species- and strain-dependent. Further research is needed to highlight which changes contribute most to improved digestibility of sprouted seeds. Such knowledge could guide the selection of varieties that are more digestible and also guide the development of food preparations that are more digestible, potentially combining germination with other factors altering digestibility, such as heating and fermentation. Techniques to characterize the shifts in protein make-up, activity and degradation during germination need to draw on traditional analytical approaches, complemented by proteomic and peptidomic analysis of mass spectrometry-identified peptide breakdown products.
Analytical Methods for Oxalate Quantification: The Ubiquitous Organic Anion
Authors: Misiewicz Bryan , Mencer Donald , Terzaghi William , VanWert Adam L.
Published: April 2023

Oxalate is a divalent organic anion that affects many biological and commercial processes. It is derived from plant sources, such as spinach, rhubarb, tea, cacao, nuts, and beans, and therefore is commonly found in raw or processed food products. Oxalate can also be made endogenously by humans and other mammals as a byproduct of hepatic enzymatic reactions. It is theorized that plants use oxalate to store calcium and protect against herbivory. Clinically, oxalate is best known to be a major component of kidney stones, which commonly contain calcium oxalate crystals. Oxalate can induce an inflammatory response that decreases the immune system’s ability to remove renal crystals. When formulated with platinum as oxaliplatin (an anticancer drug), oxalate has been proposed to cause neurotoxicity and nerve pain. There are many sectors of industry that are hampered by oxalate, and others that depend on it. For example, calcium oxalate is troublesome in the pulp industry and the alumina industry as it deposits on machinery. On the other hand, oxalate is a common active component of rust removal and cleaning products. Due to its ubiquity, there is interest in developing efficient methods to quantify oxalate. Over the past four decades, many diverse methods have been reported. These approaches include electrochemical detection, liquid chromatography or gas chromatography coupled with mass spectrometry, enzymatic degradation of oxalate with oxalate oxidase and detection of hydrogen peroxide produced, and indicator displacement-based methods employing fluorescent or UV light-absorbing compounds. Enhancements in sensitivity have been reported for both electrochemical and mass-spectrometry-based methods as recently as this year. Indicator-based methods have realized a surge in interest that continues to date. The diversity of these approaches, in terms of instrumentation, sample preparation, and sensitivity, has made it clear that no single method will work best for every purpose. This review describes the strengths and limitations of each method, and may serve as a reference for investigators to decide which approach is most suitable for their work.
Thermal Fabrication of Magnetic Fe3O4 (Nanoparticle)@Carbon Sheets from Waste Resources for the Adsorption of Dyes: Kinetic, Equilibrium, and UV–Visible Spectroscopy Investigations
Authors: Habila Mohamed A. , Moshab Mohamed S. , El-Toni Ahmed Mohamed , ALOthman Zeid A. , Badjah Hadj Ahmed Ahmed Y.
Published: April 2023

Thermal treatment is applied for the direct conversion of palm stalk waste to Fe3O4 (np)@carbon sheets (Fe3O4 (np)@CSs). The effect of conversion temperature was investigated. The TEM examination of the prepared magnetic Fe3O4 (np)@CSs showed the formation of Fe3O4 (np) in a matrix of carbon sheets as a coated layer with surface functional groups including carbonyl and hydroxyl groups. Removal of dyes such as methyl orange, methylene blue, and neutral red was achieved using fabricated Fe3O4 (np)@CSs which were prepared at 250 °C, 400 °C, and 700 °C in a weak acidic medium. By studying the contact time effect for the adsorption of methylene blue, neutral red, and methyl orange, using the fabricated Fe3O4 (np)@CSs which were prepared at 250 °C and 400 °C, equilibrium occurred between 120 min and 180 min. In addition, the first-order and second-order kinetic models were applied to the adsorption data. The results revealed that the adsorption data fit better with the second-order kinetic model. Furthermore, the Freundlich model was found to be more suitable for describing the process of the separation of the dyes onto Fe3O4 (np)@CSs which were prepared at 250 °C and 400 °C, suggesting heterogenous surfaces and multi-layer adsorption.
Advanced Carbon Nanostructures: Synthesis, Properties, and Applications
Authors: Kharlamova Marianna V. , Kramberger Christian , Chernov Alexander I.
Published: April 2023

Carbon nanomaterials are a class of materials that include allotropic modifications of carbon [...]
Temperature-Induced Irreversible Structural Transition in Fe1.1Mn1.9O4 Nanoparticles Synthesized by Combustion Method
Authors: Spivakov Aleksandr A. , Lin Chun-Rong , Chen Ying-Zhen , Huang Li-Huai
Published: April 2023

Fe1.1Mn1.9O4 nanoparticles were successfully synthesized using a combustion method. The influence of the heating temperature on the evolution of the structural and magnetic properties has been studied using various methods. The structural analysis results revealed that as-synthesized nanoparticles have a tetragonal structure with an average size of ~24 nm. The magnetic measurements of the sample showed its ferrimagnetic nature at room temperature with hysteresis at low fields. Temperature-dependent magnetization measurements allowed for the conclusion that the Curie temperature for Fe1.1Mn1.9O4 nanoparticles was ~465 °C. After high-temperature magnetic measurements, during which the samples were heated to various maximum heating temperatures (Tmax.heat.) in the range from 500 to 900 °C, it was found that the structure of the samples after cooling to room temperature depended on the heating temperature. Herewith, when the heating temperature was 600 < Tmax.heat. < 700 °C, an irreversible structural phase transition occurred, and the cooled samples retained a high-temperature cubic structure. The results of the magnetic analysis showed that the samples, following high-temperature magnetic measurements, demonstrated ferrimagnetic behavior.
In Vitro Evaluation of the Antifungal Effect of AgNPs on Fusarium oxysporum f. sp. lycopersici
Authors: Macías Sánchez Karla Lizbeth , González Martínez Hiram Deusdedut Rashid , Carrera Cerritos Raúl , Martínez Espinosa Juan Carlos
Published: April 2023

The application of nanomaterials in the agri-food industry can lead us to the formulation of new sustainable and effective pesticides for the control of fungi such as Fusarium oxysporum f. sp. lycopersici (Fol). This is a fungal plant pathogen for the tomato plant. In this work, silver nanoparticles (AgNPs) were synthesized by a green methodology from Geranium leaf extract as a reducing agent. The poisoned food technique was used to determine the percentage of inhibition of Fol mycelial growth by the action of AgNPs. They were characterized by transmission electron microscopy (TEM, JEOL JEM-2100, Tokyo, Japan) and ultraviolet-visible spectroscopy (UV-VIS, DU 730 Beckman Coulter, Brea, CA, USA). Five different concentrations of AgNPs (10, 20, 40, 75, and 150 mg/L) were evaluated in vitro in order to determine the minimum inhibitory concentration (MIC) as well as the behavior of their antifungal activity in tomato fruit. Nanoparticles with spherical morphology and average diameters of 38.5 ± 18.5 nm were obtained. The maximum percentage of inhibition on the mycelial growth of Fol was 94.6 ± 0.1%, which was obtained using the AgNPs concentration of 150 mg/L and it was determined that the MIC corresponds to 75 mg/L. On the other hand, in a qualitative way, it was possible to observe an external inhibitory effect in the tomato fruit from the concentration of 10 mg/L. Finally, we can conclude that AgNPs are a viable alternative for alternative formulations applied in the agri-food industry as pesticide solutions.
Effects of Free Linoleic Acid and Oleic Acid in Sesame Meal Extract as Pancreatic Lipase Inhibitors on Postprandial Triglyceridemia: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study in Healthy Volunteers
Authors: Li Xuan , Yamada Hiroaki , Morita Sayo , Yamashita Yusuke , Kim Youngil , Kometani Takashi , Narang Nikesh , Furuta Toma , Kim Mujo
Published: April 2023

A great number of chemically diverse pancreatic lipase (PL) inhibitors have been identified to tackle obesity; however, very few of them have entered clinical studies. The ethanolic extract of sesame meal is a potent PL inhibitor, and its activity hinges exclusively on two free fatty acids: linoleic acid and oleic acid, which were proven to reduce postprandial triglyceride excursion in rats. Herein, to investigate the clinical efficacy of the sesame meal extract, in a crossover trial, 30 healthy volunteers were randomized to receive the sesame meal extract containing experimental food or placebo along with a high-fat meal. Treatment with the sesame meal extract significantly lowered the incremental postprandial serum triglyceride concentration and reduced the incremental area under the curve (iAUC) by 16.8% (p-value = 0.03) compared to placebo. Significant decreases in postprandial remnant-like lipoprotein particle cholesterol and low-density lipoprotein particles were also observed, whereas high-density lipoprotein cholesterol was increased. These results suggest that treatment with the sesame meal extract significantly reduced the postprandial excursion of triglycerides and improved the lipidemic profile after high dietary fat intake in healthy individuals, indicating the substantial potential of free linoleic acid and oleic acid and natural products rich in these compounds for the management of obesity and related conditions.
A Systematic Review on the Optimal Dose and Duration of Ready-to-Use Therapeutic Food (RUTF) for 6–59-Month-Old Children with Severe Wasting or Oedema
Authors: Likoswe Blessings H. , Chimera-Khombe Bernadette , Patson Noel , Selemani Apatsa , Potani Isabel , Phuka John , Maleta Kenneth
Published: April 2023

The World Health Organisation (WHO) recommends that severe wasting and/or oedema should be treated with ready-to-use therapeutic food (RUTF) at a dose of 150–220 kcal/kg/day for 6–8 weeks. Emerging evidence suggests that variations of RUTF dosing regimens from the WHO recommendation are not inferior. We aimed to assess the comparative efficacy and effectiveness of different RUTF doses and durations in comparison with the current WHO RUTF dose recommendation for treating severe wasting and/or oedema among 6–59-month-old children. A systematic literature search identified three studies for inclusion, and the outcomes of interest included anthropometric recovery, anthropometric measures and indices, non-response, time to recovery, readmission, sustained recovery, and mortality. The study was registered with PROSPERO, CRD 42021276757. Only three studies were eligible for analysis. There was an overall high risk of bias for two of the studies and some concerns for the third study. Overall, there were no differences between the reduced and standard RUTF dose groups in all outcomes of interest. Despite the finding of no differences between reduced and standard-dose RUTF, the studies are too few to conclusively declare that reduced RUTF dose was more efficacious than standard RUTF.
Dysbiosis of the Gut Microbiota and Kynurenine (Kyn) Pathway Activity as Potential Biomarkers in Patients with Major Depressive Disorder
Authors: Lin Ping , Li Dan , Shi Yun , Li Qingtian , Guo Xiaokui , Dong Ke , Chen Qing , Lou Xiaoyan , Li Zhenhua , Li Ping , Jin Weifeng , Chen Shuzi , Sun Yang , Sun Jing , Cheng Xunjia
Published: April 2023

With increasing attention paid to the concept of the microbiota–gut–brain axis, mounting evidence reveals that the gut microbiota is involved in a variety of neurological and psychiatric diseases. However, gut microbiota changes in major depressive disorder (MDD) patients and their association with disease mechanisms remain undefined. Fifty MDD patients and sixty healthy controls were recruited from the Shanghai Healthy Mental Center, China. Fecal samples were collected, and the compositional characteristics of the intestinal flora were determined in MDD patients by MiSeq sequencing. Venous blood was collected for the detection of plasma indoleamine-2,3-dioxygenase (Ido), kynurenine (Kyn) and tryptophan (Trp) levels. Stool samples of bacterial 16S sequencing was carried out. A total of 2,705,809 optimized sequences were obtained, with an average of 54,116 per sample. More unique OTUs were observed at the family, genus and species levels in the control group compared with the MDD cases. Further analysis showed significant changes in the α- and β-diversities and relative abundance levels of gut microbial entities in MDD patients, as well as elevated amounts of Ido and Kyn indicating Kyn pathway activation, KEGG bacterial 16S function prediction analysis shows a variety of amino acids and metabolic (including Ido, Trp and Kyn) changes in the body of patients with MDD. These may result in increased neurotoxic metabolites and reduced generation of serotonin in the disease process. These changed factors may potentially be utilized as biomarkers for MDD in the future, playing more important roles in the disease course.