bluuebunny/crossref_metadata_2025 huggingface dataset:
Multi-Scale Correlation between Soil Loss and Natural Rainfall on Sloping Farmland Using the Hilbert–Huang Transform in Southwestern China
Authors: Shi Xiaopeng , He Shuqin , Ma Rui , Zheng Zicheng , Yi Haiyan , Liang Xinlan
Published: May 2023

The Hilbert–Huang transform (HHT) has been used as a powerful tool for analyzing nonlinear and nonstationary time series. Soil loss is controlled by complicated physical processes and thus fluctuates with nonlinearity and nonstationarity over time. In order to further clarify the relationship between rainfall, surface runoff, and sediment yield, this study adopted the HHT to analyze these characteristics through multiple time scales and investigated their relationship through time-dependent intrinsic correlation (TDIC) in the time series. A six-year study (2015–2020) was conducted on sloping farmlands to explore the relationships between soil loss and rainfall in southwest China. Time series of soil loss and rainfall were identified as the relevant characteristics at different time scales based on the method of HHT. Local correlation between the soil loss and runoff was carried out by the method of TDIC. The original time series of the rainfall, runoff, and soil loss were decomposed into eight intrinsic mode functions (IMFs) and a residue by ensemble empirical mode decomposition (EEMD). The residue indicated that the rainfall and runoff increased and then decreased during the maize-growing season from 2015 to 2020, whereas the soil loss gradually decreased. IMF1 and IMF2 accounted for nearly 80% of the temporal variations in rainfall, runoff, and soil loss, indicating that the variables varied the most at short time scales. The TDIC analysis showed that strong and positive correlations between the soil loss, rainfall, and runoff prevailed over the entire time domain at the scales of IMF1 and IMF2, indicating the rapid response of the soil loss to rainfall and runoff at short time scales. Time-varying correlations were observed at the IMF3–IMF5 scales. At the IMF7 scale, an evident switchover in the nature of the correlation was identified during the years 2018 and 2019; this could be related to a sudden rainstorm under low vegetation coverage conditions. The EEMD-based TDIC tool is an effective means to clarify the relationship between soil loss, rainfall, and runoff. Our results provide a better understanding of the relationship between soil loss and rainfall varied with time at multiple time scales. Short-term heavy rainfall and rapid surface runoff are the important factors causing serious soil and water loss on a short time scale in a mountainous region with yellow soil, which is of great significance for the construction of a regional soil erosion prediction model.
Influence of Heat Treatment on the Corrosion Resistance in Shape Memory Stainless Steel Based on FeMnSiCrNiCo
Authors: Marques Sofia Salles Lantyer , Sales-Contini Rita de Cássia Mendonça , Otubo Jorge , Bernardi Heide Heloise
Published: May 2023

In this work, the influence of heat treatment on the corrosion resistance of shape memory stainless steel based on FeMnSiCrNiCo was evaluated. Deformed samples were annealed from 250 °C to 1050 °C for 1 h. Scanning electron microscopy (SEM-EDS) and a Vickers microhardness test were used to characterize the microstructure. Thermal analysis was performed to identify phase transformations. Corrosion resistance was evaluated in an electrochemical test in a 3.5% NaCl solution. FeMnSiCrNiCo in the deformed state had better corrosion resistance compared to other conditions. However, as the annealing temperature increased, the corrosion resistance decreased due to the formation of precipitates.
Effect of Acute Melatonin Injection on Metabolomic and Testicular Artery Hemodynamic Changes and Circulating Hormones in Shiba Goats under Sub-Tropical Environmental Conditions
Authors: Samir Haney , Mandour Ahmed S. , Radwan Faten , Ahmed Ahmed Ezzat , Momenah Maha Abdullah , Aldawood Nouf Arkan , Yoshida Tomihiko , Watanabe Gen , El-Sherbiny Hossam R.
Published: May 2023

The beneficial effects of melatonin were investigated to mitigate various detrimental effects and toxicity on reproductive performance. The present study aimed, for the first time, to explore the effect of intravenous melatonin injection on testicular artery hemodynamics (TH) and metabolomic changes, reproductive hormones in heat-stressed bucks. Ten bucks were randomly split into two groups (five each): (1) the melatonin group, treated with a single intravenous dose of melatonin solution containing 10 mg melatonin each, and (2) the control group, which was treated with 10 mL of the vehicle without melatonin. Changes in the TH at the level of the supra testicular artery (STA) were assessed by triplex ultrasonography just before (0 h) and at 0.5, 2, 7, 24, and 168 h after melatonin or vehicle administration. Doppler velocity parameters of peak systolic velocity (PSV; cm/s), end-diastolic velocity (EDV; cm/s), and time average maximum velocity (TAMAX; cm/s) were measured. Doppler indices (resistive index; RI and pulsatility index; PI), systole/diastole (S/D) ratio and total arterial blood flow volume (TABFV; ml/minute) were measured. Peripheral concentrations of FSH, LH, inhibin, melatonin, testosterone (T), estradiol (E2), and cortisol were measured just before injection (0 h) and at 0.5, 2, 7, and 24 h and daily up to day 7 post administration in both groups. Results revealed reductions in the RI values and increases in the TABFV in the melatonin group compared to the control one, especially 2 h after administration. Significant increases in concentrations of FSH, T, E2, and melatonin and decreases in cortisol and inhibin in the melatonin group compared to the control one. Plasma metabolomic analysis at 2 h indicated the up-regulation of L-glutamine, L-arginine, sorbitol, D-glucose, ascorbic acid, and ornithine and the down-regulation of D-xylose, D-arabitol, ribitol, and oleic acid in the melatonin versus the control group. In conclusion, acute administration of melatonin (10 mg IV) enhanced testicular artery blood flow and plasma reproductive hormones in the Shiba goat under heat-stress circumstances.
First Isolation of Methicillin-Resistant Livestock-Associated Staphylococcus aureus CC398 and CC1 in Intensive Pig Production Farms in Argentina
Authors: Gagetti Paula , Giacoboni Gabriela Isabel , Nievas Hernan Dario , Nievas Victorio Fabio , Moredo Fabiana Alicia , Corso Alejandra
Published: May 2023

Since the mid-2000s, livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) has been identified among pigs worldwide, CC398 being the most relevant LA-MRSA clone. In the present work, nasal swabs were taken from healthy pigs of different age categories (25 to 154 days) from 2019 to 2021 in four intensive farms located in three provinces of Argentina. The aim of the present study was to characterize the first LA-MRSA isolates that colonized healthy fattening pigs in Argentina in terms of their resistance phenotype and genotype and to know the circulating clones in the country. Antimicrobial susceptibility, presence of the mecA gene and PCR screening of CC398 were evaluated in all the isolates. They were resistant to cefoxitin, penicillin, tetracycline, chloramphenicol and ciprofloxacin but susceptible to nitrofurantoin, rifampicin, vancomycin and linezolid. Furthermore, 79% were resistant to clindamycin and lincomycin, 68% to erythromycin, 58% to gentamicin and 37% to trimethoprim/sulfamethoxazole. All the isolates were multidrug resistant. The clonal relation was assessed by SmaI-PFGE (pulsed-field gel electrophoresis) and a representative isolate of each PFGE type was whole genome sequenced by Illumina. MLST (multilocus sequence typing), resistance and virulence genes and SCCmec typing were performed on sequenced isolates. The isolates were differentiated in three clonal types by PFGE, and they belonged to sequence-type ST398 (58%) and ST9, CC1 (42%) by MLST. SCCmec typeV and several resistance genes detected showed complete correlation with resistance phenotypes. The present study revealed that LA-MRSA colonizing healthy pigs in Argentina belongs to CC398 and CC1, two MRSA lineages frequently associated to pigs in other countries.
Cardiac Changes after Lactate-Guided Conditioning in Young Purebred Arabian Horses
Authors: Santos Maíra M. , Ramos Gabriel V. , de Figueiredo Isabela M. , Silva Tainá C. B. V. , Lacerda-Neto José C.
Published: May 2023

Cardiac adaptation to conditioning in horses was evaluated after empirical training based on trainers’ experience. Twelve purebred Arabian horses, aged (mean ± SD) 28.42 ± 3.75 months, which did not perform any type of exercise prior to the research, were submitted to treadmill conditioning for six weeks. The conditioning program was based on the velocity run by the horse at which the blood lactate concentration, determined in an incremental exercise test (IET), reached 2 mmol/L (V2). The velocity at which the blood lactate concentration reached 4 mmol/L (V4) was also determined. The echocardiograms were performed at rest with pulsed-wave and tissue Doppler imaging in B- and M-modes. All procedures were carried out before and after the conditioning period. The results showed increases in V2 (from 5.2 ± 0.3 to 6.7 ± 0.4 m/s) and V4 (from 5.8 ± 0.4 to 7.6 ± 0.5 m/s) (p < 0.0001). There were also increases in the left ventricle internal diameter at diastole (LVIDd), left ventricle mass (LV mass), and stroke volume (SV), while no changes were observed in the LV free wall thickness and mean and relative wall thicknesses. The conditioning protocol, which was completed by all horses, proved to be safe and efficient, as it improved the aerobic capacity of the animals. Finally, the cardiac remodeling that occurred was mainly associated with the effect of physical training.
Validation of Standing and Locomotion Scoring, Behavioral Assessments, and Mechanical Nociceptive Threshold Testing on Naturally Occurring Sow Lameness
Authors: Forseth Anna K. , Karriker Locke A. , Millman Suzanne T. , Stalder Kenneth J. , Parsons Rebecca L. , Azarpajouh Samaneh , Johnson Anna K.
Published: May 2023

The objective of this study was to validate standing and locomotion lameness scoring, mechanical nociceptive threshold testing, and behavioral profile tools for the diagnosis of naturally occurring lameness etiologies in pigs. A total of 55 crossbred gilts and sows obtained from a commercial farm were enrolled in the study; with sound pigs classified as controls (8) and the remainder as lame due to integumentary (20), musculoskeletal (15), and combinations of integumentary and musculoskeletal (12) etiologies. Standing and locomotion lameness, mechanical nociceptive threshold (MNT) test, pig-human interventions, and latency to complete an obstacle course were evaluated. Standing and locomotion lameness scoring systems, MNT, and pig behavior (latency) were capable of discriminating between animals with mild organic lameness and animals that were sound and may have utility on the farm for staff to use to identify and manage lame animals. In rare instances, the tools used here were able to discriminate between broad categories of lameness etiology.
From Obesity-Induced Low-Grade Inflammation to Lipotoxicity and Mitochondrial Dysfunction: Altered Multi-Crosstalk between Adipose Tissue and Metabolically Active Organs
Authors: Cavaliere Gina , Cimmino Fabiano , Trinchese Giovanna , Catapano Angela , Petrella Lidia , D’Angelo Margherita , Lucchin Lucio , Mollica Maria Pina
Published: May 2023

Obesity is a major risk factor for several metabolic diseases, including type 2 diabetes, hyperlipidemia, cardiovascular diseases, and brain disorders. Growing evidence suggests the importance of inter-organ metabolic communication for the progression of obesity and the subsequent onset of related disorders. This review provides a broad overview of the pathophysiological processes that from adipose tissue dysfunction leading to altered multi-tissue crosstalk relevant to regulating energy homeostasis and the etiology of obesity. First, a comprehensive description of the role of adipose tissue was reported. Then, attention was turned toward the unhealthy expansion of adipose tissue, low-grade inflammatory state, metabolic inflexibility, and mitochondrial dysfunction as root causes of systemic metabolic alterations. In addition, a short spot was devoted to iron deficiency in obese conditions and the role of the hepcidin–ferroportin relationship in the management of this issue. Finally, different classes of bioactive food components were described with a perspective to enhance their potential preventive and therapeutic use against obesity-related diseases.
Barkhausen Noise Emission as a Function of Tensile Stress in Low-Alloyed Steels: Influence of Corrosion and Steel Strength
Authors: Bahleda František , Neslušan Miroslav , Pastorek Filip , Koňár Radoslav , Kubjatko Tibor
Published: May 2023

Components of civil buildings are frequently made of low-alloyed steel, which can suffer from corrosion damage. This damage reduces their bearing capacity and/or redistributes the load to neighboring regions with the potential risk of their collapse. For this reason, this study deals with the non-destructive monitoring of bodies made of these steels based on Barkhausen noise emission. The superimposing contribution of corrosion extent and exerted tensile load is investigated on samples of variable yield strength in the range from 235 to 1100 MPa. It is found that the presence of a corroded layer attenuates Barkhausen noise and makes the body harder from a magnetic point of view. The reduced effective thickness of the samples as a result of corrosion damage increases the true stress. Barkhausen noise grows along with the tensile stress in the direction of exerted stress at the expense of decreasing Barkhausen noise in the perpendicular direction. The evolution of Barkhausen noise versus tensile stress is mostly shifted to the lower values of Barkhausen noise, along with the increasing degree of corrosion damage. The evolution of Barkhausen noise versus tensile stress is also affected by the initial microstructure and the corresponding yield strength of the low-alloyed steel. Corrosion attack results in the growth of FWHM, which is compensated by the decreasing evolution along with the tensile stresses. The effective values drop down with the higher extent of corrosion damage. However, the response with respect to the tensile stress is asymmetric in RD and TD due to the realignment of DWs into RD. Finally, PP tends to increase with the corrosion attack as well as the tensile stress and this parameter only exhibits the systematic behavior in RD as well as TD. On the other hand, MBN-extracted parameters as well as their combination provide no exclusive values on which the pure contribution of corrosion and tensile stress can be distinguished.
Bioinformatics-Based Characterization of ATP-Binding Cassette Subfamily B Member 1 (ABCB1) Gene Expression in Non-Small-Cell Lung Cancer (NSCLC)
Authors: Jeleń Agnieszka Maria , Strehl Bartłomiej , Szmajda-Krygier Dagmara , Pązik Milena , Balcerczak Ewa
Published: May 2023

P-glycoprotein (P-gp) has been implicated in lung cancer development, disease progression, and patient survival. Changes in the ABCB1 expression level may correlate with tumorigenesis and the formation of multidrug resistance (MDR). In addition, epigenetic modifications such as DNA methylation are involved in the regulation of the transcriptional activity of this gene. Therefore, we focused on an analysis of changes in the expression of ABCB1 and its methylation, taking into account their potential associations with the clinicopathological parameters of LUAD and LUSC. The TNMplot, UALCAN, cBioPortal, PrognoScan, and MEXPRESS databases were used to investigate the role of this gene in lung cancer progression. ABCB1 expression in lung tissue was significantly downregulated in cancer cells, but differences also resulted from age, gender, ethnicity, and smoking cessation. Moreover, decreased levels of gene transcript were associated with both a higher stage of cancer and a lower probability of survival. It is worth emphasizing that the presence/direction of ABCB1 expression changes are frequently unique to specific histological tumor subtypes. Finally, it is equally important that the main methylation promoter is one of the causes of decreased gene expression in lung cancer cells. Taken together, these data establish the ABCB1 transporter gene as an important prognostic factor that could alter disease progression and contribute to the survival of cancer patients.
A Novel PCA-Based Method for PRNU Distillation to the Benefit of Source Camera Identification
Authors: Li Jian , Liu Yang , Ma Bin , Wang Chunpeng , Qin Chuan , Wu Xiaoming , Li Shuanshuan
Published: May 2023

Photo response non-uniformity (PRNU) is a widely accepted inherent fingerprint that has been used in source camera identification (SCI). However, the reference PRNU noise is limited by the performance of PRNU noise extraction techniques and is easily contaminated by interfering noise from image content. The existing methods mainly suppressed the interference noise of the reference PRNU noise in the spectral domain, but there was still interference noise related to the image content in the low-frequency region. We considered that this interference noise of the reference PRNU noise could be removed by further operations in the spatial domain. In this paper, we proposed a scheme to distil the reference PRNU by removing the interference noise with the help of principal component analysis (PCA) technology. Specifically, the reference PRNU noise was modelled as white Gaussian noise, whereas the interfering noise caused correlation between pixels and their neighbourhoods in the reference PRNU noise. In the local pixel area, we modelled a pixel and its neighbours as a vector and used block matching to select PCA training samples with similar contents. Next, PCA transformation estimated the interference noise in the local pixel area, and we performed coefficient shrinkage in the PCA domain to better estimate interference noise. The experimental results on the “Dresden” and “VISION” datasets showed that the proposed scheme achieved better receiver operating characteristic curves and the Kappa statistic than state-of-the-art works.
Robust Control of RSOC/Li-ion Battery Hybrid System Based on Modeling and Active Disturbance Rejection Technology
Authors: Wu Xiaolong , Li Yu , Gao Zilin , Xu Yuanwu , Peng Jingxuan , Xia Zhiping , Hu Lingyan , Hu Jiangong , Wang Zhuo , Li Xi
Published: May 2023

The application of new energy systems for industrial production to advance air pollution prevention and control has become an irreversible trend. This development includes hybrid systems consisting of reversible solid oxide cells (RSOC) and a Li-ion battery; however, at present the energy dispatching of such systems has an unstable factor in the form of poor heat/electricity/gas controllability. Therefore, the system studied in this paper uses the Li-ion battery as the energy supply/storage case, and uses the RSOC to supply power for the Li-ion battery charge or the Li-ion battery supply power to the RSOC for hydrogen production by water electrolysis. In this hybrid system, Li-ion battery thermoelectric safety and RSOC hydrogen production stability are extremely important. However, system operation involves the switching of multiple operating conditions, and the internal thermoelectric fluctuation mechanism is not yet clear. Therefore, in this paper we propose a separate control with a dual mode for hybrid systems. Active disturbance rejection control (ADRC) with a simple structure is used to achieve Li-ion battery module thermoelectric safety and control the hydrogen production/consumption of the RSOC module in the hybrid system. The results show that the required Li-ion battery thermoelectric safety and RSOC hydrogen consumption/production requirements can be met using the proposed controller, leading to a hybrid system with high stability control.
Facile Synthesizing Yolk-Shelled Fe3O4@Carbon Nanocavities with Balanced Physiochemical Synergism as Efficient Hosts for High-Performance Lithium–Sulfur Batteries
Authors: Chen Lai , Zhao Chenying , Lu Yun , Wan Lingyi , Yan Kang , Bai Youxiang , Liu Zhiyu , Yang Xulai , Su Yuefeng , Wu Feng
Published: May 2023

The severe “shuttle effect” of dissolved polysulfide intermediates and the poor electronic conductivity of sulfur cathodes cause capacity decay of lithium–sulfur batteries and impede their commercialization. Herein, we synthesized a series of well-designed yolk-shelled Fe3O4@carbon (YS-Fe3O4@C) nanocavities with different proportions of Fe3O4 as efficient sulfur hosts to stabilize polysulfide intermediates. The yolk-shelled nanocavity architectures were prepared through a facile method, which could effectively confine the active materials and achieve high conductivity. The polysulfide intermediate shuttle was successfully suppressed by a physiochemical synergism effect combining the retention of carbon shells and the adsorption of Fe3O4 nanoparticle cores. The highly conductive carbon shell provides efficient pathways for fast electron transportation. Meanwhile, the visible evolution of active materials and a reversible electrochemical reaction are revealed by in situ X-ray diffraction. With the balanced merits of enhanced electrical conductivity of carbon shell and optimal adsorption of Fe3O4 cores, the S/YS-27Fe3O4@C cathode (Fe3O4 accounts for 27 wt% in YS-Fe3O4@C) had the best electrochemical performance, exhibiting a high reversible specific capacity of 731.9 mAh g−1 and long cycle performance at 1 C (capacity fading rate of 0.03% over 200 cycles).
Fe3C-Decorated Folic Acid-Derived Graphene-like Carbon-Modified Separator as a Polysulfide Barrier for High-Performance Lithium-Sulfur Batteries
Authors: Lin Zenghui , Feng Junan , Liu Wendong , Yin Lu , Chen Wanyang , Shi Chuan , Song Jianjun
Published: May 2023

The lithium-sulfur (Li-S) battery has been regarded as an important candidate for the next-generation energy storage system due to its high theoretical capacity (1675 mAh g−1) and high energy density (2600 Wh kg−1). However, the shuttle effect of polysulfide seriously affects the cycling stability of the Li-S battery. Here, a novel Fe3C-decorated folic acid-derived graphene-like N-doped carbon sheet (Fe3C@N-CS) was successfully prepared as the polysulfide catalyst to modify the separator of Li-S batteries. The porous layered structures can successfully capture polysulfide as a physical barrier and the encapsulated Fe3C catalyst can effectively trap and catalyze the conversion of polysulfide, thus accelerating the redox reaction kinetics. Together with the highly conductive networks, a cell with the Fe3C@N-CS-modified separator evinces superior cycling stability with 0.06% capacity decay per cycle at 1 C rate over 500 cycles and excellent specific capacity with an initial capacity of 1260 mAh g−1 at 0.2 C. Furthermore, at a high sulfur loading of 4.0 mg cm−2, the batteries also express superb cycle stability and rate performance.
On-Shore Plastic Waste Detection with YOLOv5 and RGB-Near-Infrared Fusion: A State-of-the-Art Solution for Accurate and Efficient Environmental Monitoring
Authors: Tamin Owen , Moung Ervin Gubin , Dargham Jamal Ahmad , Yahya Farashazillah , Farzamnia Ali , Sia Florence , Naim Nur Faraha Mohd , Angeline Lorita
Published: May 2023

Plastic waste is a growing environmental concern that poses a significant threat to onshore ecosystems, human health, and wildlife. The accumulation of plastic waste in oceans has reached a staggering estimate of over eight million tons annually, leading to hazardous outcomes in marine life and the food chain. Plastic waste is prevalent in urban areas, posing risks to animals that may ingest it or become entangled in it, and negatively impacting the economy and tourism industry. Effective plastic waste management requires a comprehensive approach that includes reducing consumption, promoting recycling, and developing innovative technologies such as automated plastic detection systems. The development of accurate and efficient plastic detection methods is therefore essential for effective waste management. To address this challenge, machine learning techniques such as the YOLOv5 model have emerged as promising tools for developing automated plastic detection systems. Furthermore, there is a need to study both visible light (RGB) and near-infrared (RGNIR) as part of plastic waste detection due to the unique properties of plastic waste in different environmental settings. To this end, two plastic waste datasets, comprising RGB and RGNIR images, were utilized to train the proposed model, YOLOv5m. The performance of the model was then evaluated using a 10-fold cross-validation method on both datasets. The experiment was extended by adding background images into the training dataset to reduce false positives. An additional experiment was carried out to fuse both the RGB and RGNIR datasets. A performance-metric score called the Weighted Metric Score (WMS) was proposed, where the WMS equaled the sum of the mean average precision at the intersection over union (IoU) threshold of 0.5 (mAP@0.5) × 0.1 and the mean average precision averaged over different IoU thresholds ranging from 0.5 to 0.95 (mAP@0.5:0.95) × 0.9. In addition, a 10-fold cross-validation procedure was implemented. Based on the results, the proposed model achieved the best performance using the fusion of the RGB and RGNIR datasets when evaluated on the testing dataset with a mean of mAP@0.5, mAP@0.5:0.95, and a WMS of 92.96% ± 2.63%, 69.47% ± 3.11%, and 71.82% ± 3.04%, respectively. These findings indicate that utilizing both normal visible light and the near-infrared spectrum as feature representations in machine learning could lead to improved performance in plastic waste detection. This opens new opportunities in the development of automated plastic detection systems for use in fields such as automation, environmental management, and resource management.
Neonatal Seizure Detection Using a Wearable Multi-Sensor System
Authors: Chen Hongyu , Wang Zaihao , Lu Chunmei , Shu Feng , Chen Chen , Wang Laishuan , Chen Wei
Published: May 2023

Neonatal seizure is an important clinical symptom of brain dysfunction, which is more common in infancy than in childhood. At present, video electroencephalogram (VEEG) technology is widely used in clinical practice. However, video electroencephalogram technology has several disadvantages. For example, the wires connecting the medical instruments may interfere with the infant’s movement and the gel patch electrode or disk electrode commonly used to monitor EEG may cause skin allergies or even tears. For the above reasons, we developed a wearable multi-sensor platform for newborns to collect physiological and movement signals. In this study, we designed a second-generation multi-sensor platform and developed an automatic detection algorithm for neonatal seizures based on ECG, respiration and acceleration. Data for 38 neonates were recorded at the Children’s Hospital of Fudan University in Shanghai. The total recording time was approximately 300 h. Four of the patients had seizures during data collection. The total recording time for the four patients was approximately 34 h, with 30 seizure episodes recorded. These data were evaluated by the algorithm. To evaluate the effectiveness of combining ECG, respiration and movement, we compared the performance of three types of seizure detectors. The first detector included features from ECG, respiration and acceleration records; the second detector incorporated features based on respiratory movement from respiration and acceleration records; and the third detector used only ECG-based features from ECG records. Our study illustrated that, compared with the detector utilizing individual modal features, multi-modal feature detectors could achieve favorable overall performance, reduce false alarm rates and give higher F-measures.
The Role of Retinal Pigment Epithelial Cells in Age-Related Macular Degeneration: Phagocytosis and Autophagy
Authors: Si Zhibo , Zheng Yajuan , Zhao Jing
Published: May 2023

Age-related macular degeneration (AMD) causes vision loss in the elderly population. Dry AMD leads to the formation of Drusen, while wet AMD is characterized by cell proliferation and choroidal angiogenesis. The retinal pigment epithelium (RPE) plays a key role in AMD pathogenesis. In particular, helioreceptor renewal depends on outer segment phagocytosis of RPE cells, while RPE autophagy can protect cells from oxidative stress damage. However, when the oxidative stress burden is too high and homeostasis is disturbed, the phagocytosis and autophagy functions of RPE become damaged, leading to AMD development and progression. Hence, characterizing the roles of RPE cell phagocytosis and autophagy in the pathogenesis of AMD can inform the development of potential therapeutic targets to prevent irreversible RPE and photoreceptor cell death, thus protecting against AMD.
Chimera and Tandem-Repeat Type Galectins: The New Targets for Cancer Immunotherapy
Authors: Ko Frankie Chi Fat , Yan Sheng , Lee Ka Wai , Lam Sze Kwan , Ho James Chung Man
Published: May 2023

In humans, a total of 12 galectins have been identified. Their intracellular and extracellular biological functions are explored and discussed in this review. These galectins play important roles in controlling immune responses within the tumour microenvironment (TME) and the infiltration of immune cells, including different subsets of T cells, macrophages, and neutrophils, to fight against cancer cells. However, these infiltrating cells also have repair roles and are hijacked by cancer cells for pro-tumorigenic activities. Upon a better understanding of the immunomodulating functions of galectin-3 and -9, their inhibitors, namely, GB1211 and LYT-200, have been selected as candidates for clinical trials. The use of these galectin inhibitors as combined treatments with current immune checkpoint inhibitors (ICIs) is also undergoing clinical trial investigations. Through their network of binding partners, inhibition of galectin have broad downstream effects acting on CD8+ cytotoxic T cells, regulatory T cells (Tregs), Natural Killer (NK) cells, and macrophages as well as playing pro-inflammatory roles, inhibiting T-cell exhaustion to support the fight against cancer cells. Other galectin members are also included in this review to provide insight into potential candidates for future treatment(s). The pitfalls and limitations of using galectins and their inhibitors are also discussed to cognise their clinical application.
Differences in the Intracellular Localization of Methylated β-Cyclodextrins-Threaded Polyrotaxanes Lead to Different Cellular States
Authors: Yamada Yuma , Daikuhara Shinnosuke , Tamura Atsushi , Nishida Kei , Yui Nobuhiko , Harashima Hideyoshi
Published: May 2023

Activation of autophagy represents a potential therapeutic strategy for the treatment of diseases that are caused by the accumulation of defective proteins and the formation of abnormal organelles. Methylated β-cyclodextrins-threaded polyrotaxane (Me-PRX), a supramolecular structured polymer, induces autophagy by interacting with the endoplasmic reticulum. We previously reported on the successful activation of mitochondria-targeted autophagy by delivering Me-RRX to mitochondria using a MITO-Porter, a mitochondria-targeted nanocarrier. The same level of autophagy induction was achieved at one-twentieth the dosage for the MITO-Porter (Me-PRX) compared to the naked Me-PRX. We report herein on the quantitative evaluation of the intracellular organelle localization of both naked Me-PRX and the MITO-Porter (Me-PRX). Mitochondria, endoplasmic reticulum and lysosomes were selected as target organelles because they would be involved in autophagy induction. In addition, organelle injury and cell viability assays were performed. The results showed that the naked Me-PRX and the MITO-Porter (Me-PRX) were localized in different intracellular organelles, and organelle injury was different, depending on the route of administration, indicating that different organelles contribute to autophagy induction. These findings indicate that the organelle to which the autophagy-inducing molecules are delivered plays an important role in the level of induction of autophagy.
Effects of Game-Specific Demands on Accelerations during Change of Direction Movements: Analysis of Youth Female Soccer
Authors: Alanen Aki-Matti , Benson Lauren C. , Jordan Matthew J. , Ferber Reed , Pasanen Kati
Published: May 2023

The aim of this study was to assess center of mass (COM) acceleration and movement during change of direction (COD) maneuvers during a competitive soccer game to elucidate situation-specific demands of COD performance. This information can assist in developing soccer-specific tests and training methods. Fifteen elite-level female youth soccer players were tracked for one game with inertial measurement units (IMU) attached to the lower back. COD movements in combination with situational patterns were identified using high-speed video. LASSO regression was used to identify the most important predictors associated with higher vertical peak accelerations (PAv) of the COM during COD movements. COD angle, running speed, contact, and challenge from the opposition were identified as important features related to higher PAv. This study adds to the literature on the demands of COD performance in soccer match-play. The unique approach with game-specific situational data from female youth players provides increased insight into the game-demands of COD and agility performance. PAv in games was higher with larger COD angles, increased running speed, or with contact when the player was challenged by the opposition. A larger study including more games is warranted to increase confidence in using these variables as a basis for training or testing agility.
Hesperidin Attenuates Hypothyroidism-Induced Lung Damage in Adult Albino Rats by Modulating Oxidative Stress, Nuclear Factor Kappa-B Pathway, Proliferating Cell Nuclear Antigen and Inflammatory Cytokines
Authors: Hegazy Walaa , Sakr Hader I. , Abdul Hamid Manal , Abdelaziz Mohamed A. , Salah Marwa , Abdel Rehiem Eman S. , Abdel Moneim Adel
Published: May 2023

The occurrence of worsening pulmonary function has been connected to hypothyroidism (HPO). Hesperidin (HES) was suggested to have antioxidant, anti-proliferative, and anti-inflammatory potential. Our study’s objective was to determine whether HES could reduce carbimazole (CBZ)-induced lung injury more effectively than Eltroxin (ELT) in adult male albino rats or not. At random, 32 rats were distributed into four groups: Group I: normal control, to induce HPO, the remaining three groups were given CBZ (20 mg/kg/day) dissolved in distilled water for 1 week. They were then split up into three groups. Group II: orally administered CBZ (20 mg/kg b.w in water/day), Group III: HES (200 mg/kg/day) dissolved in 1% carboxymethyl-cellulose + CBZ treated, and Group IV: ELT (0.045 mg/kg/day) dissolved in distilled water + CBZ treated. All treatments were delivered for 12 weeks. Blood was collected to assess thyroid-stimulating hormone (TSH) and thyroid hormones (THs). Lung injury was evaluated based on the pulmonary content of interleukin (IL)-35, IL-6, and tumor necrosis factor-alpha (TNF-α), along with the estimation of lipid peroxidation, catalase, glutathione levels, superoxide dismutase, heme oxygenase-1 (HO-1), and nuclear factor erythroid 2-related factor 2 (Nrf2). The histological, ultrastructural, and immunohistochemical study of nuclear factor Kappa-B (NF-κB) and inducible nitric oxide synthase (iNOS), together with estimating the proliferation of cells using Antigen Ki-67 in lung tissue were performed. HES and ELT primarily suppressed variable lung damage mechanisms by suppressing TSH, the NF-κB/TNF-α pathway, iNOS, lipid peroxidation, Ki-67, and inflammatory mediators. On the other hand, they improved THs, antioxidant parameters, and the Nrf2/HO-1 pathway. HES and ELT exhibited an ameliorative effect that was reflected in the histopathological, immunohistochemical, and ultrastructural results. These results indicate that HES is a pneumoprotective agent that could be a promising treatment for oxidative stress, inflammation, and proliferation.
A Review of Robotic Fish Based on Smart Materials
Authors: Ma Shiwei , Zhao Quanliang , Ding Meixi , Zhang Mengying , Zhao Lei , Huang Can , Zhang Jie , Liang Xu , Yuan Junjie , Wang Xingtao , He Guangping
Published: May 2023

The present study focuses on summarizing the recent advancements in the field of fish swimming mode research and bionic robotic fish prototypes based on smart materials. It has been widely acknowledged that fish exhibit exceptional swimming efficiency and manoeuvrability compared to conventional underwater vehicles. In the pursuit of developing autonomous underwater vehicles (AUVs), conventional experimental methods often prove to be complex and expensive. Hence, the utilization of computer simulations for hydrodynamic modelling provides a cost-effective and efficient approach for analysing the swimming behaviour of bionic robotic fish. Additionally, computer simulations can provide data that are difficult to obtain through experimental methods. Smart materials, which integrate perception, drive, and control functions, are increasingly being applied to bionic robotic fish research. However, the utilization of smart materials in this field is still an area of ongoing research and several challenges remain unresolved. This study provides an overview of the current state of research on fish swimming modes and the development of hydrodynamic modelling. The application of four distinct types of smart materials in bionic robotic fish is then reviewed, with a focus on analysing the advantages and disadvantages of each material in driving swimming behaviour. In conclusion, the paper highlights the key technical challenges that must be addressed for the practical implementation of bionic robotic fish and provides insights into the potential future directions of this field.
A Study on the Layout of Hospital Ward Buildings in Cold Regions of China Based on the Efficiency of Nurse Rounds
Authors: Deng Qingtan , Jiao Chenxia , Wang Guangbin , Song Xiaoyi , Zang Jiayao
Published: May 2023

As an important public facility, the number, area, and scale of hospital buildings are growing rapidly. The efficiency of nurses’ rounds to beds is an important indicator of the efficiency of nursing units in ward buildings. Ward buildings occupy a very important position in the overall energy consumption of hospital building complexes. The type and scale of nursing unit floorplans are some of the key factors affecting the energy consumption of ward buildings. In this paper, three typical floorplan layout types of hospital ward buildings in cold regions of China are selected. The relationships between rounding efficiency, building energy consumption, floorplan layout, and building size were quantified using Origin based on linear regression and non-linear regression. The study showed that at 60 beds, the efficiency of nurse rounds was 35.68% higher in the double-corridor layout compared to the single-corridor. At 44 beds, the difference in average bed energy consumption between the double-corridor type and the single-corridor type is the greatest, with a 9.02% saving in energy consumption. This result confirms that the layout and scale of the ward building has a significant impact on the efficiency of nursing unit rounds and building energy efficiency.
Recent Advancement in Breast Cancer Research: Insights from Model Organisms—Mouse Models to Zebrafish
Authors: Singhal Sharad S. , Garg Rachana , Mohanty Atish , Garg Pankaj , Ramisetty Sravani Keerthi , Mirzapoiazova Tamara , Soldi Raffaella , Sharma Sunil , Kulkarni Prakash , Salgia Ravi
Published: May 2023

Animal models have been utilized for decades to investigate the causes of human diseases and provide platforms for testing novel therapies. Indeed, breakthrough advances in genetically engineered mouse (GEM) models and xenograft transplantation technologies have dramatically benefited in elucidating the mechanisms underlying the pathogenesis of multiple diseases, including cancer. The currently available GEM models have been employed to assess specific genetic changes that underlay many features of carcinogenesis, including variations in tumor cell proliferation, apoptosis, invasion, metastasis, angiogenesis, and drug resistance. In addition, mice models render it easier to locate tumor biomarkers for the recognition, prognosis, and surveillance of cancer progression and recurrence. Furthermore, the patient-derived xenograft (PDX) model, which involves the direct surgical transfer of fresh human tumor samples to immunodeficient mice, has contributed significantly to advancing the field of drug discovery and therapeutics. Here, we provide a synopsis of mouse and zebrafish models used in cancer research as well as an interdisciplinary ‘Team Medicine’ approach that has not only accelerated our understanding of varied aspects of carcinogenesis but has also been instrumental in developing novel therapeutic strategies.
Treating Primary Node-Positive Prostate Cancer: A Scoping Review of Available Treatment Options
Authors: Zuur Lotte G. , de Barros Hilda A. , van der Mijn Koen J. C. , Vis André N. , Bergman Andries M. , Pos Floris J. , van Moorselaar Jeroen A. , van der Poel Henk G. , Vogel Wouter V. , van Leeuwen Pim J.
Published: May 2023

There is currently no consensus on the optimal treatment for patients with a primary diagnosis of clinically and pathologically node-positive (cN1M0 and pN1M0) hormone-sensitive prostate cancer (PCa). The treatment paradigm has shifted as research has shown that these patients could benefit from intensified treatment and are potentially curable. This scoping review provides an overview of available treatments for men with primary-diagnosed cN1M0 and pN1M0 PCa. A search was conducted on Medline for studies published between 2002 and 2022 that reported on treatment and outcomes among patients with cN1M0 and pN1M0 PCa. In total, twenty-seven eligible articles were included in this analysis: six randomised controlled trials, one systematic review, and twenty retrospective/observational studies. For cN1M0 PCa patients, the best-established treatment option is a combination of androgen deprivation therapy (ADT) and external beam radiotherapy (EBRT) applied to both the prostate and lymph nodes. Based on most recent studies, treatment intensification can be beneficial, but more randomised studies are needed. For pN1M0 PCa patients, adjuvant or early salvage treatments based on risk stratification determined by factors such as Gleason score, tumour stage, number of positive lymph nodes, and surgical margins appear to be the best-established treatment options. These treatments include close monitoring and adjuvant treatment with ADT and/or EBRT.
Surgery of Colorectal Liver Metastases Involving the Inferior Vena Cava: A Systematic Review
Authors: Serradilla-Martín Mario , Oliver-Guillén José Ramón , Ruíz-Quijano Pablo , Palomares-Cano Ana , de la Plaza-Llamas Roberto , Ramia José Manuel
Published: May 2023

Combined hepatic and inferior vena cava (IVC) resection is the only potentially curative treatment for patients with colorectal liver metastases (CRLM) involving the IVC. Most of the existing data come from case reports or small case series. In this paper, a systematic review based on the PICO strategy was performed in accordance with the PRISMA statement. Papers from January 1980 to December 2022 were searched in Embase, PubMed, and the Cochrane Library databases. Articles considered for inclusion had to present data on simultaneous liver and IVC resection for CRLM and report surgical and/or oncological outcomes. From a total of 1175 articles retrieved, 29, including a total of 188 patients, met the inclusion criteria. The mean age was 58.3 ± 10.8 years. The most frequent techniques used were right hepatectomy ± caudate lobe for hepatic resections (37.8%), lateral clamping (44.8%) for vascular control, and primary closure (56.8%) for IVC repair. The thirty-day mortality reached 4.6%. Tumour relapse was reported in 65.8% of the cases. The median overall survival (OS) was 34 months (with a confidence interval of 30–40 months), and the 1-year, 3-year, and 5-year OS were 71.4%, 19.8%, and 7.1%, respectively. In the absence of prospective randomized studies, which are difficult to perform, IVC resection seems to be safe and feasible.
Special Issue “New Developments in Natural Killer Cells for Immunotherapy”
Authors: Zimmer Jacques , Jurišić Vladimir
Published: May 2023

Since their formal discovery in 1975, natural killer (NK) cells have always been proposed in the literature as a potential treatment for cancer and viral infections [...]
Child Abuse, Misdiagnosed by an Expertise Center: Part I—Medico-Social Aspects
Authors: Vlaming Marianne , Sauer Pieter J. J. , Janssen Emile P. F. , van Koppen Peter J. , Bruijninckx Cornelis M. A. , Akkerman-Zaalberg van Zelst Marga W. M. , Neumann H. A. Martino , van Gemert Martin J. C.
Published: May 2023

Child abuse is a dangerous situation for an infant. Professionals need to weigh the risk of failing to act when children are seriously harmed against the serious harm done by carrying out safeguarding interventions. In severe cases, foster care might be advisable. The negative effects for the child’s psychosocial development requires that such placement must be based on very solid evidence. Our aim is to identify why Dutch parents whose child may have a medical condition that could mimic symptoms of child abuse have a significant chance of being erroneously convicted and losing custody of their child. As a method, we describe and analyze the following case. An Armenian-Dutch newborn (uncomplicated term vaginal delivery), starting at two weeks after birth, developed small bruises on varying body locations. At two months, a Well-Baby Clinic physician referred the girl to a university hospital, mentioning that there were no reasons to suspect child abuse and that her Armenian grandmother easily bruised as well. However, before consultation by a pediatrician of the hospital-located Expertise Center for Child Abuse, the parents were suspected of child abuse. Based on the expertise center’s protocols, skeletal X-rays were made, which showed three healed, asymptomatic rib fractures, while invalid statistics suggested, incorrectly, a 10–100 times more likely non-accidental than accidental cause of the symptoms (discussed in Part II of this series). The expertise enter physician ignored any argument that could show parental innocence, including the positive parent-child relationship reported by the Well-Baby Clinic and the general practitioner. The girl and her older brother were placed in a family foster home and then in a secret home. The case radically resolved when a large bruise also developed there, and an independent tissue disease specialist diagnosed a hereditary connective tissue disorder in the mother, implying that the girl’s bruises and rib fractures could well be disease-related. In conclusion, if child abuse is suspected, and foster care placement considered, the patient and the parents should be thoroughly investigated by an independent experienced pediatrician together with an experienced pediatric clinical psychologist or psychotherapist to produce an independent opinion. Children deserve this extra safeguard before being separated from their parents.