bluuebunny/crossref_metadata_2025 huggingface dataset:
Chemical constituents and evidence-based pharmacological properties of Physalis peruviana L.: An overview
Authors: Kasali Félicien Mushagalusa , Tuyiringire Naasson , Peter Emanuel L , . Ahovegbe Lucrèce Y , Ali Muhammad Shaiq , Tusiimire Jonans , Ogwang Patrick Engeu , Kadima Justin Ntokamunda , Agaba Amon Ganafa
Published: March 2022

Physalis peruviana L. is among plant species possessing evident nutritional, nutraceutical, and commercial interests. This review highlights the complexity of the chemical composition supporting the multiple pharmacotherapeutic indications and dietary values of this plant through evidence-based studies from Google Scholar, PubMed/Medline, SciFinder, Science Direct, Scopus, the Wiley online library, and Web of Science. The literature mentions at least 40 compounds isolated from different parts; others are still under investigation. High yields in carotenoids, amino acids, minerals, vitamin C, vitamin E, and essential fatty acids have healthy nutritional benefits. Various phytoconstituents, particularly withanolides, exhibit anti-carcinogenic, anti-inflammatory, and antidiabetic potentials, as well as cardiovascular and liver protective effects. Prospective studies reveal that the leaves would also provide various beneficial bioactive chemicals worth being isolated. However, clinical evidence-based studies are seldom. Therefore, adequate pharmaceutical formulations and more in-depth controlled clinical trials are needed to fill the gap.
In vitro anti-melanogenic effect of Perilla frutescens leaf extracts
Authors: Nguyen Thi-Thuy-Anh , Do Thanh-Hao , Pham Thi-Thu-Hien , Huynh Ngoc-Trinh
Published: March 2022

Introduction: Perilla frutescens (L.) Britt leaves contain various phenolic compounds, especially flavonoids, which potentially inhibit tyrosinase, the key enzyme catalyzing the melanin synthesis pathway. This work aimed to investigate the anti-melanogenic effect of Perilla frutescens extracts through the inhibition of non-cellular as well as cellular tyrosinase activities. Methods: The total extract from Perilla frutescens leaves was obtained by percolation method with 50% ethanol followed by liquid–liquid partition with ethyl acetate (EA) and chloroform (CF) to obtain the EA, CF and EA/CF extracts. The mushroom tyrosinase inhibitory effect of the obtained extracts was screened by dopachrome formation reactions from its substrate 3,4-dihydroxy-L-phenylalanine. The extracts with potential activity were further evaluated for the anti-melanogenic effects in the B16F10 melanoma cell line. Results: EA and EA/CF extracts significantly inhibited mushroom tyrosinase activity with the IC50s of 0.14 and 0.07 mg/mL, respectively, in the same range of that from kojic acid (0.12 mg/mL). Consistently, in B16F10 cells, these extracts inhibited tyrosinase enzyme; their IC50 values were 2 times lower than that of kojic acid. Moreover, both EA and EA/CF extracts remarkably reduced melanin levels in a concentration-dependent manner. Conclusion: The EA and EA/CF extracts from Perilla frutescens leaves were able to inhibit melanogenesis by reducing tyrosinase activity.
Antioxidant properties of extract combination of Coccinia grandis and Blumea balsamifera: An in vitro synergistic effect
Authors: Putra I Made Wisnu Adhi , Fakhrudin Nanang , Kusumawati I Gusti Ayu Wita , Nurrochmad Arief , Wahyuono Subagus
Published: March 2022

Introduction: As single extracts, Coccinia grandis and Blumea balsamifera have been known to have potent antioxidant activities. However, the synergistic antioxidant effect of the combination of these plant extracts was unknown. In this study, the combination of C. grandis and B. balsamifera extracts was investigated for its antioxidant and synergistic properties. Methods: Separately, C. grandis and B. balsamifera leaves were extracted with ethanol. After evaporation, the thick extracts were assayed for their total phenolic content (TPC) and total flavonoid content (TFC). The antioxidant properties of single and combined extracts were measured using the molybdenum(VI) reducing power, ferric reducing antioxidant power (FRAP), 2,2-diphenyl-1-picrylhydrazyl (DPPH), and 2,2-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) methods. The possible synergism effect was evaluated using the checkerboard method and the combination index values were also calculated. Results: The TPC and TFC of the B. balsamifera extracts were much greater than that of C. grandis extract. In the molybdenum(VI) reducing power and FRAP assay, the reducing power of the extract combination increased as B. balsamifera extract concentration increased (P < 0.05). In the ABTS+ and DPPH radical scavenging assays, B. balsamifera extract demonstrated a higher antioxidant activity than C. grandis extract (P < 0.05). When combined, increasing the concentration of B. balsamifera caused an increase in the radical scavenging activity (P < 0.05). Synergism was observed in the combination of the extracts with low concentration ratios. Conclusion: In this study, we showed that the combination of C. grandis and B. balsamifera leaf extracts possessed synergistic antioxidant properties.
Rhinacanthin-C enhances chemosensitivity of breast cancer cells via the downregulation of P-glycoprotein through inhibition of Akt/NF-kappa B signaling pathway
Authors: Chaisit Suwichak , Jianmongkol Suree
Published: March 2022

Introduction: High expression of P-glycoprotein (P-gp) has been linked to multidrug resistance (MDR) and chemotherapeutic failure. Previously, we demonstrated that rhinacanthin-C, a naphthoquinone from Rhinacanthus nasutus, was able to enhance the cytotoxicity of doxorubicin against breast cancer MCF-7 cells via direct P-gp inhibition. In this study, we looked at its effect on P-gp downregulation and the mechanism involved in the resistance of MCF-7 cells to doxorubicin. Methods: Doxorubicin-resistant MCF-7 (MCF-7/DOX) cells were exposed to rhinacanthin-C for 24-48 hours prior to the assessment of their chemosensitivity via MTT assay, P-gp activity via calcein-AM uptake assay, P-gp expression, and signaling via qRT-PCR and western blot analyses. Results: Pretreatment with 1 µM of rhinacanthin-C for 48 hours significantly enhanced cytotoxicity of doxorubicin, as well as camptothecin and etoposide, to MCF-7/DOX cells. In the rhinacanthin-C-treated cells, reduction of MDR1 mRNA and P-gp levels and increased intracellular calcein were observed. Moreover, phosphorylation of Akt, NF-ᴋB and IκB-α, along with YB-1 expression, significantly decreased after 24-hour treatment with rhinacanthin-C. In contrast, the naphthoquinone had no effect on expression levels of ERK1/2 and phosphorylated ERK1/2 under similar conditions. Conclusion: Rhinacanthin-C, at a non-cytotoxic concentration (1 µM), could downregulate P-gp expression in MCF-7/DOX cells via the inhibition of the Akt/NF-ᴋB signaling pathway and YB-1 expression. Long-term exposure to this natural naphthoquinone may increase the chemosensitivity of cancer cells with MDR phenotype.
Preliminary phytochemical screening, acute toxicity and effect of Albuca amoena extracts on the central nervous system
Authors: Zakhour Rajaâ , El Jemly Meryem , El Guourrami Otman , Nejjari Rachid , Bouyahya Abdelhakim , Cherrah Yahia , Alaoui Katim
Published: March 2022

Introduction: Albuca amoena is a Moroccan-Algerian endemic medicinal plant with various implications. The aim of this study is to identify phytochemical compounds of the plant, check its acute toxicity, and test its anti-depressive, anxiolytic, and analgesic effects on the central nervous system (CNS). Methods: The estimation of chemical compounds was carried out according to coloring and precipitation reactions. The Organization of Economic Cooperation and Development guidelines 423 and 402 made it possible to verify the acute toxicity of the plant orally and dermally. The sedative activity was performed according to 4 tests: rotarod, hole-board, traction, and chimney tests. The anti-depressive, anxiolytic, and analgesic effects were evaluated by forced swimming, light/dark, and writhing tests, respectively. Results: The phytochemical analysis showed that A. amoena contained a mixture of phytochemical compounds like terpenes, alkaloids, and polyphenols. According to the acute toxicity tests, the lethal dose of 50% (LD50) of A. amoena hydroalcoholic extract was between 300 and 2000 mg/kg orally and higher than 2000 mg/kg dermally. Moreover, the result of the behaviour tests of sedative and analgesic activities revealed that A. amoena hydroalcoholic extract exerted positive effects on the CNS. Conclusion: These results show the anti-depressive, anxiolytic, and analgesic effects of the bioactive substances present in A. amoena on the CNS and provide access to further investigations to highlight the main compounds of this plant and their mechanisms of actions.
RETRACTION NOTE: Effect of curcumin on hippocampus dentate gyrus injury induced by nicotine in rats
Authors: Jalili Cyrus , Arji Rodsari Babak , Roshankhah Shiva , Salahshoor Mohammad Reza
Published: March 2022

This paper was published in the Journal of Herbmed Pharmacology in 2019 (doi: 10.15171/jhp.2019.47) (1). Based on an email received from the team of young researchers recently, we were informed that the results of this article (some figures and diagrams) have been published in several similar articles (2-5), which are considered ethical misconduct. This issue was investigated by the editorial team of the Journal of Herbmed Pharmacology. As a result, based on the Committee on Publication Ethics (COPE) guidelines, the editors decided to retract this paper. The authors were informed and advised on this serious ethical breach. This article has been retracted at the request of the corresponding author. The retracted article will remain online to maintain the scholarly record, but it will be watermarked on each page as ‘retracted’. References 1.Jalili C, Arji Rodsari B, Roshankhah S, Salahshoor MR. Effect of curcumin on hippocampus dentate gyrus injury induced by nicotine in rats. J Herbmed Pharmacol. 2019;8(4):320-327. doi: 10.15171/jhp.2019.47. 2.Roshankhah S, Abdolmaleki A, Jalili C, Salahshoor MR. Ameliorative Effect of Falcaria vulgaris on Nicotine-induced Injury on the Hippocampus Dentate Gyrus Region of Rats. Int J Pharm Invest. 2019;9(4):200-204. 3.Roshankhah S, Jalili C, Salahshoor MR. Falcaria vulgaris attenuates morphine toxicity in prefrontal cortex in rats. Egyptian Pharmaceutical Journal. 2019;18:276-84. doi: 10.4103/epj.epj_18_19. 4.Roshankhah S, Sadeghi E, Jalili C, Salahshoor MR. Impacts of Low‑Protein Diet on the Hippocampal CA1 Neurons and Learning Deficits in Rats. Adv Hum Biol. 2019;9:124-8. doi: 10.4103/AIHB.AIHB_31_19. 5.Salahshoor MR, Abdolmaleki A, Roshankhah S, Jalali A, Jalili C. Curcumin recovers the toxic effects of nicotine on hippocampus cornu ammonis 1 in rats. J Pharmacol Pharmacother. 2019;10:85-92. doi: 10.4103/jpp.JPP_38_19.
The Tourism Sector in Country Branding: An Assessment on Health Tourism in Turkey
Authors: İLDAŞ Görkem
Published: March 2022

Investments made and resources owned in the field of health in Turkey have increased the interest in health tourism, which is one of the types of tourism with the highest added value. In consequence of factors such as globalization, international collaborations, the expansion of people’s travel opportunities, the increase in the elderly population, the rising awareness of people who want to live healthy and long, and the fact that people can have instant information about new treatment methods thanks to the effect of digitization, health tourism is of critical importance for countries to promote themselves and raise their reputations. Health tourism, which can be served throughout the year regardless of a season, differs from other types of tourism both in this respect and due to the diversity of its target audience. This study aims to examine the place of health tourism in general country promotion strategies by discussing the promotional activities in health tourism at the national and international levels. This study, which is based on literature analysis, aims to determine the potential of the country, to discuss different promotion strategies and methods that can be created in accordance with the target audiences, and to deal with communication activities. In the light of the researches, if Turkey can manage its health tourism well, it has the potential to be increasingly preferred over the years by international patients, especially in some branches (plastic surgery, ophthalmology, dentistry, gynecology, otolaryngology, physiotherapy, and rehabilitation, etc.), due to its thermal resources, trained manpower, and treatment methods adapted to the latest technologies. Travel restrictions due to the Covid-19 epidemic, the changing priorities of medical tourists, and the reports on the health policies of countries have directly affected the accelerating health tourism. In this context, it is predicted that countries that manage this crisis well will increase their reputation and credibility in health tourism. It is believed that assessing medical tourism within the country branding and presenting it with current examples will benefit all stakeholders in the field. Additionally, it is believed that the study will be a guide for marketing professionals, public relations specialists, advertisers, and researchers who will carry out promotional activities in this field.
Yaşayan Tarih: Savaş Alanları Turizmi ve Yeniden Canlandırma Toplulukları Örneği
Authors: AKBULUT Onur , EKİN Yakın
Published: March 2022

Post-modern toplumda refah düzeyindeki iyileşme, bilgi iletişim teknolojileri ve ulaşımdaki teknolojik gelişmelerle artan turizm hareketliliği tarihi sunum çeşitliliğini artırmıştır. İnsanlık tarihi boyunca yaşanmış dönemler, olaylar ve savaşlar; internet, film, dizi, bilgisayar oyunları ve turizm gibi ortamlardaki sunumlarla tekrar erişime açılmıştır. Kitle turizminin dünyaya yayılması sonrasında alternatif turizm ve özel ilgi turizmi de turizmin işleyiş biçimini çeşitlendirmiştir. Turizmin artan çeşitliliği geleneksel turizm türlerinden deneyim odaklı turizm türlerine geçişi hızlandırmıştır. Savaş alanları turizmi ve yaşayan tarih, deneyim odaklı turizmin parçasıdır. Yaşayan bir olgu olan tarihin ağırlıklı olarak ölü olarak adlandırılabilecek sayfalarla sunumu günümüzde farklılaşmaktadır. Bu sunumlardan biri de savaş alanları turizmi kapsamında yaşayan tarih topluluklarıdır. Bu çalışmada yaşayan tarih toplulukları betimleyici örnek olay çalışması ile ele alınmıştır. İkincil kaynaklardan veriler elde edilmiştir. Bu veriler ışığında dünya genelinde yer alan yaşayan tarih toplulukları ile ilgili bilgiler derlenmiştir. Tarihin turizm yoluyla hem öğrenme hem de eğlenme aracılığıyla gelecek nesillere aktarılması konusunda bazı öneriler getirilmiştir.
Hubungan Obesitas Dengan Gangguan Pendengaran
Authors: Pangemanan Gracia E. M. , Runtuwene Joshua , Pelealu Olivia C. P.
Published: March 2022

Abstract: Hearing loss is the loss of the ability to hear sound frequencies within the normal hearing range. Hearing loss can have various effects that reduce the quality of life. Obesity is a risk factor for hearing loss, but this relationship is still uncertain. This study aims to determine whether there is a relationship between obesity and hearing loss.. This research was made in the form of a literature review using three databases, namely Google Scholar, PubMed, ClinicalKey. The literature to be used can be in the form of English and or Indonesian, within the last 10 years (2011) and can be accessed in fulltext. Based on the results of 11 studies, it was found that obesity can increase the risk of hearing loss. In conclusion, obesity is a risk factor for hearing loss in both adolescents and adults. Obesity comorbidities have a role in the mechanism of hearing loss.Keywords: Obesity, Hearing loss  Abstrak: Gangguan pendengaran merupakan kehilangan kemampuan mendengar frekuensi suara dalam rentang pendengaran normal. Gangguan pendengaran dapat membawa berbagai dampak yang menurunkan kualitas hidup. Obesitas merupakan salah satu faktor risiko dari gangguan pendengaran, namun hubungan ini masih belum dapat dipastikan. Penelitian ini bertujuan untuk mengetahui apakah ada hubungan antara obesitas dengan gangguan pendengaran. Penelitian ini dibuat dalam bentuk literature review dengan menggunakan tiga database, yaitu Google Scholar, PubMed, ClinicalKey. Literatur yang akan digunakan dapat berbentuk Bahasa Inggris dan atau Bahasa Indonesia, dalam jangka waktu 10 tahun terakhir (2011) dan dapat diakses secara penuh. Berdasarkan hasil dari 11 penelitian, didapatkan bahwa obesitas dapat meningkatkan risiko gangguan pendengaran. Sebagai simpulan, obesitas merupakan faktor risiko terjadinya gangguan pendengaran baik pada remaja, maupun orang dewasa. Penyakit penyerta obesitas memiliki peran pada mekanisme gangguan pendengaran. Kata kunci: obesitas, gangguan pendengaran
Hubungan Harga Diri dan Narsisme pada Siswa dan Mahasiswa Pengguna Media Sosial di Indonesia
Authors: Thiro Frisbile T. , Sinolungan Jehosua S. V. , Pali Cicilia
Published: March 2022

Abstract: The purpose of this study is to there was a correlation between self-esteem and Narcissism in Junior Highschool Students, Senior Highschool Students and College Students that use social media actively by collecting some of the literature that will be used for research literature review. Search data using two databases, Pubmed and Google Scholar. At the stage of selection of literature it was found that the ten literature that meets the inclusion and exclusion criteria. The number of samples research on the ten literature is 1.082 which consists of Junior Highschool Students, Senior Highschool Students and College Students who are actively using social media. The results of studies from ten literature review shows that there is a significant relationship between self-esteem and narcissism in junior highschool student, senior highschool student and college student that use social media. Of the ten journals, there were five journals that had a positive relationship between self-esteem and narcissism, with a total 737 samples while the other five journals had a negative relationship between self-esteem and narcissism with 345 samples.Keywords: The relationship between self esteem and narcissism, junior highschool students, senior highschool students and college students  Abstrak: Tujuan dari studi ini adalah untuk mengetahui mengetahui apakah memang ada hubungan antara Harga diri dan Narsisme pada siswa SMP, siswa SMA dan Mahasiswa yang menggunakan media sosial secara aktif dengan cara mengumpulkan beberapa literature-literature yang nantinya akan digunakan untuk penelitian literature review. Pencarian data menggunakan dua database yaitu Pubmed dan Google Scholar. Pada tahap seleksi literature maka ditemukan sepuluh literature yang memenuhi kriteria inklusi dan eksklusi. Jumlah sampel penelitian pada sepuluh literature tersebut adalah 1.082 yang terdiri dari Siswa dan Mahasiswa yang aktif menggunakan media sosial. Hasil penelitian dari sepuluh literature review menunjukan bahwa terdapat hubungan yang signifikan antara harga diri dan narsisme. Dari kesepuluh jurnal didapatkan lima jurnal yang memiliki hasil hubungan yang positif antara harga diri dan narsisme dengan jumlah sampel dari kelima jurnal tersebut adalah 737 sampel, sedangkan kelima jurnal yang lain didapatkan hasil hubungan yang negatif antara harga diri dan narsisme dengan jumlah 345 sampel.Kata kunci: hubungan harga diri dan narsisme, Siswa SMP, Siswa SMA, Mahasiswa
Gambaran Kesehatan Mental Pada Lansia Selama Pandemi COVID-19
Authors: Kiroh Amanda G. M. , Kairupan Bernabas H. R. , Munayang Herdy
Published: March 2022

Abstract: Coronavirus disease (COVID-19) pandemic was first found in Wuhan, China on December 2019. The government did restricts people's activities to prevent the spread of the virus, especially in elderly people due to higher risk and vulnerability, but mental health issues and bad influence can arise with such social restriction and social distancing. This study aims to provide an overview of the mental health condition especially in the elderly communities during the COVID-19 pandemic. This study was made in the form of a literature review using three databases, namely Google Scholar and Clinical Key. The research design used is literature review, using three databases, namely Google Scholar and Clinical Key. The literature that used is in English and Indonesian, within the last one year (year 2020) and fully-accessible.Based on the literature reviewed, it is found that there are activity restrictions have a negative impact on the mental health of the elderly, and not only affect the mental health, but also has an unfavorable influence on other aspects.Keywords: elderly mental health, COVID-19 Pandemic  Abstrak: Pandemi Covid-19 Coronavirus Disease 2019 (Covid-19) pertama kali didiagnosis pada Desember 2019 di Wuhan Cina. Pemerintah melakukan pembatasan aktivitas kepada masyarakat guna untuk mencegah terjadinya penyebaran virus terutama pada orang yang sudah lanjut usia karena mereka memiliki risiko yang lebih tinggi dan rentan untuk terkena Covid-19, tapi dengan adanya pembatasan jarak sosial ini dapat memberikan pengaruh yang kurang baik bagi lansia terutama pada kesehatan mental mereka. Tujuan penelitian ini bertujuan untuk mengetahui gambaran kesehatan mental pada lansia selama pandemi Covid-19. Penelitian ini dibuat dalam bentuk literature review dengan menggunakan tiga database, yaitu Google Scholar dan Clinical Key. Literatur yang akan digunakan dapat berbentuk Bahasa Inggris dan atau  Bahasa  Indonesia,  dalam  jangka  waktu  satu  tahun  terakhir  (2020)  dan  dapat  diakses  secara penuh. Berdasarkan literature-literature yang di review didapatkan pembatasan aktivitas memberikan dampak yang negatif bagi kesehatan mental lansia, dan bukan hanya berpengaruh pada kesehatan mental saja tapi juga memberikan pengaruh yang kurang baik pada aspek-aspek lainnya.Kata Kunci: Kesehatan mental lansia, pandemi Covid-19
Bicornuate Uterus with Previous C-Section: A Case Report
Authors: Suparman Erna
Published: March 2022

Abstract: Bicornuate uterus is a type of Mullerian duct malformation caused by incomplete fusion of fundal uterine cornu that leads to two connected uterine cavities and one cervix. The incidence of bicornuate uterus is estimated to be 0.1-0.6% and it is believed to account for 10% of all uterine anomalies. We reported a case of bicornuate uterus with previous cesarean sections in an expecting mother presented in labor during her 38-39 weeks of pregnancy. She had a history of two previous cesarean sections. Based on physical examination and transabdominal USG, the fetus was found in breech presentation. She was managed with another cesarean section. During the operation it was found that she had a bicornuate uterus. The main problems for this case were pregnancy with bad obstetric history, previous cesarean sections, breech presentation, and complications that could occur in future pregnancy. The patient was presented already in labor, so she was managed with emergency cesarean section to reduce the risk of uterine rupture. During the operation, she was found to have a bicornuate uterus. This proved that the cause of repeated breech presentation was one of the complications that could occur in pregnancy with bicornuate uterus. The most ideal management for this patient was elective cesarean section. In conclusion, uterine abnormalities are accompanied with uneventful outcomes such as preterm labour, fetal malpresentations, and even perinatal mortality. However, these anomalies may not be suspected before the occurrence of abortion or its complications. A high index of suspicion is needed to diagnose uterine abnormalities before the occurence of its complicationsKeywords: bicornuate uterus; breech presentation; pregnancy; Mullerian duct anomalies
The Role of Bone Marrow Mesenchymal Stem Cells and Adipose Tissue-Derived Stem Cells in the Treatment of Liver Failure: A Literature Review
Authors: Ziedan Mohamed , Ayman Maha , Mohamed Dina
Published: March 2022

Liver disease is a major health problem that endangers human health worldwide. Stem cells have the unique ability to morph or differentiate into different types of cells within the body. In this way, stem cells can be used to seek out damaged liver tissue and regenerate the organ itself. Mesenchymal stem cells are multipotent stem cells that can self-renew and differentiate into different cell types. In other words, mesenchymal stem cells can become a variety of different cell types including adipose tissue, cartilage, muscle, tendon/ligament, bone, neurons, and hepatocytes. Many studies have shown that Mesenchymal stem cells play an essential role in liver recovery, and further research has verified the preliminary effectiveness and safety of these therapies. types of liver disease that are most suitable for MSC application should be determined, and the preparation and engraftment of MSCs should be standardized. Stem cell-based therapies will emerge as an effective treatment strategy for liver diseases in now and the future. Researchers conduct an examination of articles that are in accordance with the issue to be studied. Articles used in literature review are obtained through the database of international journal providers through PubMed, we investigated six clinical studies and discussed what happened in these clinical studies and the extent of the effectiveness of stem cells in treatment and whether the degree of liver disease had a role in the effectiveness of stem cells, we also discussed the mechanism of stem cells in treatment. One of six articles proved that Zeaxanthin dipalmitate (ZD) could enhance the defensive abilities against adverse stresses of human adipose-derived mesenchymal stem cells, One of six articles proved that infusion of allogeneic bone marrow-derived MSCs improving liver function and decreasing the incidence of severe infections. The rest articles proved that  MSCs both Bone Marrow Stem cells (BMSCs) and Adipose Derived Stem Cells (ADSCs) are promising therapeutic agents for the liver fibrosis and cirrhosis treatment. In this review, we suggest that formulating and following treatment, Further studies are needed to determine the related mechanisms to enhance MSC efficacy.
The Effect of the Combination of Counseling and Dhikr Interventions: Self-Acceptance of the Elderly in Nursing Home
Authors: Minarti Minarti , Kastubi Kastubi , Fadilah N , Shifaza Fathimath
Published: March 2022

Individuals who become elderly will experience physical changes from their initial body condition to being very weak. The declining conditions experienced by the elderly tend to cause physical and psychological health problems and dissatisfaction in life. The purpose of this study is to analyze counseling and dhikr intervention on the attitude of self-acceptance of the elderly. An experimental design using pre-test and post-test control groups was conducted among 30 elderly people living in nursing homes with the inclusion criteria of being able to communicate well, not deaf, not cognitively impaired, or depressed. Participants were randomly allocated, to the intervention group at Nursing Home of Jambangan and the control group at Nursing Home of Hargo Dedali in Surabaya Indonesia. Measurement of self-acceptance was carried out twice through a questionnaire, namely before the counseling and dhikr intervention and 8 weeks after. Data were analyzed using paired t-test. The results showed that there is pre-post differences in the group that received counseling and dhikr intervention (p-value = 0.000). The participants in the intervention group showed an increase in self-acceptance while in the control group there is no significant difference with a p-value of 0.937. Religious support for dhikr and counseling needs to be carried out intensively for the elderly as religious activities can provide a sense of peace, surrender, and surrender to Allah Almighty. The combination of counseling and dhikr is an effort to improve oneself spiritually and has a positive correlation with the attitude of self-acceptance of the elderly living in nursing homes. Institutions where services for the elderly can contribute to the elderly living in nursing homes by carrying out programmatic activities, namely counseling, especially for the elderly who have just entered special institutions for the elderly, spiritual approaches also need to be improved both in groups and individuals such as prayer, dhikr, and worship. others according to ability. A very important contribution is the guidance carried out by cleric so that elderly worship is more focused. This is an effort so that the elderly can accept the conditions they are facing and can accept themselves living in the orphanage.
Garbage Sorting as an Important Rural Problem: Descriptive Study of Priority Health Problems in Pantai Cermin Village, Langkat Regency
Authors: Hasibuan Rapotan , Salsabila Atikah
Published: March 2022

In planning efforts to improve public health degrees, it is necessary to plan the first steps to find out what health problems are prioritized to be addressed effectively, efficiently, and on target. This community service, therefore, aim to to find health problems in order to find the right intervention so that the health problems contained in Teladan Hamlet do not become serious problems that cause other health problems. This research was conducted in Teladan hamlet of Pantai Cermin Village, Tanjung Pura Subdistrict using descriptive research methods, univariate analysis was conducted to determine the priority of health problems from the results of self-aware surveys. Prioritization of health problems was carried out qualitatively using the Focus Group Discussion method with USG (Urgency, Seriousness, Growth) criteria scoring. The nine highest health problems found were the low number of couples who did not use contraception, low infant weight, itching, hypertension, national health insurance, smoking behavior, kitchen waste disposal, garbage sorting, and eradication of mosquito nests. The results of the Focus Group Discussion agreed that the priority of health problems in Teladan hamlet is the low behavior of waste sorting, so that interventions are carried out in the form of counseling and provision of facilities and infrastructure in the form of garbage cans in some public places in order to increase public knowledge and community behavior in sorting waste. Efforts that can be made by local governments are to support and supervise the community to implement good and correct waste sorting and processing behavior in a sustainable manner
Correlation between Husband's Perception and Support with Wife's Interest in Using Modern Contraception in Couple Unmet Need
Authors: Belinda Anindita  , Ervi Husni  , Sutio Rahardjo
Published: March 2022

Unmet need are couples of childbearing age who are not using contraception but who wish to postpone the next birth (spacing) or stop childbearing altogether (limiting). unmet need in Indonesia reached 10.6% and East Java Province reached 7.7%. The number of unmet need in KB Sidotopo Village RW 05 was 27.8% and RW 12 was 35.9%. This study aims to determine the correlation between husband's perception and support with wife's interest in using modern contraception in couple unmet need. This study used a cross-sectional design. The population was reproductive-age couples whose unmet needs. A total of 159 couples was taken by purposive sampling technique. The instrument used was a questionnaire. To analyze used Spearman Rank Test with (0.05). The result shows that the husband's perception is (50.9%) negative, the husband's support is (57.2%) unsupportive, and the wife's interest (39.0%) is low. The results using the Spearman Rank test of husband's perception obtained a p-value of 0.000 < (0.05), which means a correlation between husband's perception and wife's interest in unmet need. For the husband's support, the p-value is 0.000 < (0.05), which means that there is a correlation between husband's support and wife's interest in unmet need. This research is useful to make couples of childbearing age aware of the importance of family planning. It is hoped that couples of childbearing age can obtain and seek more information about family planning.
Implementasi Visi Pendidikan Berbasis Agama, Filsafat, Psikologi, Dan Sosiologi Di Lembaga Pendidikan Islam
Authors: Afifah Rasma , Nurjaman Ujang , Fatkhulloh Faiz Karim
Published: March 2022

Visi merupakan gambaran tentang masa depan (future) yang realistik dan ingin mewujudkan dalam kurun waktu tertentu. Visi adalah pernyataan yang diucapkan atau ditulis hari ini, yang merupakan proses manajemen saat ini dan menjangkau masa yang akan datang. Agar pengelolaan madrasah tersebut dapat berjalan dengan baik, dibutuhkan rencana strategis sebagai suatu upaya untuk mengendalikan organisasi(madrasah) secara efektif dan efesien sehingga tujuan dan sasarannya tercapai. Perencanaan strategis merupakan landasan bagi madrasah dalam menjalankan proses pendidikan. Komponen dalam perencanaan strategis paling tidak terdiri dari visi, misi, prinsip dan tujuan. Perumusan tersebut harus dilakukan pengelola madrasah, agar memiliki arah kebijakan yang dapat menunjang tercapainya tujuan yang diharapkan. Pendidikan merupakan proses sosial yang bertujuan membentuk manusia yang baik. Pendidikan dalam arti luas diartikan sebagai proses pengembangan semua aspek kepribadian manusia, baik aspek pengetahuan, nilai dan sikap, maupun keterampilan yang berbasis pada agama, filsafat, psikologis dan sosiologis. Agama memerintahkan manusia untuk mempelajari alam, menggali hukum-hukumnya agar manusia hidup secara alamiah sesuai dengan tujuan dan asas moral  yang diridhai  Tuhan. Ilmu sebagai alat harus diarahkan oleh agama, supaya memperoleh kebaikan dan kebahagiaan, sebaliknya ilmu tanpa agama, maka akan membawa bencana dan kesengsaraan. Karena agama adalah kebenaran, sementara filsafat dan ilmu adalah pencari kebenaran, maka keduanya (filsafat dan ilmu) harus mencari kebenaran agama tersebut.

 
Pengembangan Media Pembelajaran IPS ASIAPP (Asean Interaction App) pada Materi Interaksi Antarnegara-Negara ASEAN SMP Kelas VIII
Authors: Arifin Alvia Arifta , Adi Khofifatu Rohmah
Published: March 2022

Kegiatan pembelajaran memerlukan perencanaan dalam pelaksanaannya. Salah satu bagian yang harus direncanakan yaitu dengan menyiapkan media pembelajaran. Dalam hal ini, media pembelajaran yang dikembangkan akan membahas materi mengenai interaksi antar negara-negara ASEAN pada tingkatan kelas VIII SMP/MTs. Hal ini dikarenakan materi tersebut bersifat abstrak dan sulit dijangkau karena mencakup wilayah Asia Tenggara yang luas. Media dibutuhkan agar dapat memvisualisasikan bentuk konkret dari adanya interaksi yang terjalin tersebut. Media pembelajaran dibuat dengan menggunakan softwarevideoscribe yang dipadukan dengan aplikasi smart apps creator. Perpaduan ini kemudian akan menghasilkan produk akhir berupa aplikasi android bernama ASIAPP (ASEAN Interaction APP). Peneliti juga memilih topik ini dengan tujuan untuk mengembangkan media pembelajaran yang layak pada materi interaksi antarnegara-negara ASEAN. Penelitian ini menggunakan metode Research and Development (R&D) berpedoman pada desain ADDIE. Hasil penelitian dan pengembangan ini menunjukkan skor sebesar 100 % untuk validasi pada sudut pandang materi, 87,5 % untuk validasi pada sudut pandang kebahasaan, serta 95 % untuk validasi pada sudut pandang media pembelajaran. Sedangkan uji coba yang dilakukan kepada calon pengguna memperoleh persentase skor total sebesar 87 %. Oleh karena itu, media pembelajaranASIAPP (ASEAN Interaction APP) termasuk ke dalam kategori media yang “sangat layak”untukdapat digunakan menjadi media pembelajaran IPS SMP/MTskelas VIII.
PENGORGANISASIAN DALAM PENDIDIKAN
Authors: Subekti Imam
Published: March 2022

Pengorganisasian dalam dunia pendidikan sangat diperlukan dan sangat dibutuhkan baik itu pendidikan dibawah naungan pihak swasta maupun negeri. Ketika tujuan pendidikan itu telah dicapai maka seluruh pihak yang terlibat seperti sumber daya manusia, kompetensi dan fasilitas harus dipersiapkan secara matang dan baik. Penelitian ini menggunakan metode penelitian normatif atau penelitian doctrinal yang mana sumber data sekunder atau penelitan kepustakaan yang akan digunakan dalam penelitian ini, yaitu dengan menelaah bahan sekunder berupa buku ilmiah, jurnal, dan lain-lain. Yang dianalisis adalah Bahan sekunder atau penelitian kepustakaan kemudian dianalisis dan disajikan secara deskriptif.  Organisasi sebagai salah satu fungsi manajemen pendidikan dapat disimpulkan sebagai berikut: organisasi adalah aktivitas-aktivitas menyusun dan membentuk hubungan-hubungan sehingga terwujudlah kesatuan usaha dalam mencapai maksud-maksud dan tujuan-tujuan pendidikan. Jenis organisasi Lini dan staf sangat cocok diterapkan di sekolah. Karena kerjasama antara pendidik, tenaga kependidikan dan kepala sekolah sangat diperlukan dalam rangka mencapai tujuan sekolah.

Kata kunci: Pengorganisasian; Organisasi; Pendidikan; Kerjasama, Manusia.
COVID-19 is a Conspiracy Disease? Diagnostic Mental Models and Students' Cognitive Abilities
Authors: Septaria Kiki , Fatharani Atika , Yasa Arnelia Dwi
Published: March 2022

Countless research has been published on the impact of covid-19 on improvements in teaching techniques, activities, and motivational beliefs. Most research refers to a human's response before learning without testing students' comprehension and literacy linked to covid-19. This study adopted a qualitative approach, with a questionnaire serving as the primary research tool. Alternatively, the current study looks into students' cognitive and portrays their mental model of COVID-19. At the Islamic University of Lamongan, 30 students from the science education department and 30 students from the environmental health department took part. Students are chosen as transformational leaders and liaisons between society's academic and social environments. The researchers gather data based on an open-ended assessment that evaluates the concepts, causation, methods, and strategies that must be implemented to prevent the transmission of COVID-19. Participants completed questionnaires prepared for educational purposes before and after learning. Inductive and iterative investigation of the descriptions of students' answers revealed cognitive outcomes and mental models. Each questionnaire form is then checked for validity using the SPSS v24 program. The authenticity of the questionnaire responses for each questionnaire > rcount (N = 60), indicating that each question is valid, whereas the reliability test using Cronbach's Alpha provides a score of 0.78 > 0.60, indicating that the questionnaire employed is trustworthy. Regarding educational, cognitive processes, the analysis shows that some colleagues believe that COVID-19 is a conspiracy, while others need to add sufficient scientific literacy to validate that COVID-19 is a disease. Even after learning, they can only make general ways to mitigate the propagation of COVID-19. The findings for student mental models revealed considerable changes in clarity and coherence, such as models at levels 1 through 5 with the highest student mental models. This study culminates with the implication that students require scientific literacy to effectively communicate about COVID-19 and check out false information in public.
Metacognition in Science Learning: Bibliometric Analysis of Last Two Decades
Authors: Wirzal Mohd Dzul Hakim , Halim Nur Syakinah Abdul , Md Nordin Nik Abdul Hadi , Bustam Mohamad Azmi
Published: March 2022

The main objective of this study was to map (1) the research of metacognition in science learning; (2) learning interventions used and metacognition’s key components that learned, integrated, and investigated; and (3) future research recommendations of metacognition research in science learning. We analyzed 438 scientific documents published in journals and books indexed in the Scopus database using VOSviewer software to visualize research trends and main keywords investigated of metacognition in science learning. The research findings show that research in the field of metacognition in science learning through the metacognition as attribution that integrated into learning interventions and as a learning outcome has increased in the last two decades. Scientific concepts understanding, critical thinking skills, motivation, and attention are the main goals in metacognition research. Inquiry-based learning, such as problem-based learning, is the most frequently used intervention to teach students metacognition. The research gaps found are (1) the cognitive regulations are the most investigated aspect, while cognitive aspects such as declarative knowledge, procedural knowledge, and conditional knowledge have not been widely investigated in science learning; (2) metacognition research on college students has a high frequency compared to school students; and (3) the integration of metacognition in online learning is still less investigated, this is indicated by the recommendations of several research results that encourage the integration of self-regulated learning into online learning.
Collision of Polycystic Ovarian Syndrome Scenarios on Specific Health Related-Quality of Life among a sample at "Maternity and Children Teaching Hospital" in Diwaniyah city –Iraq
Authors: Abdalhassan Anaam , Zedian Muna , Al-Naqeeb Abdulkhaleq
Published: March 2022

Objectives: Study objectives to discover collision scenarios status through studying the most properties of specific health related-quality of life (SHR-QoL) of polycystic ovarian syndrome (PCOS) patients, as well as to find out relationships among redistribution of overall evaluating the contents of specific questionnaire with some related anthropometric variables concerning studied patents, such as, (BMI, and WHR), as well as socio-economic status of the studied patients.

Methodology: Specific development questionnaire of (PCOS) for women are applicable. A descriptive study of patients with PCOS are conducted, and it was starting data collection from the 6th December 2020 up to 10th May 2021from the "Maternity and Children Teaching Hospital" in Diwaniyah city–Iraq". Convenient sampling of (100) patients who were visiting to that hospital during the data are collected. In addition to that, (Alpha Cronbach-α) for the internal consistency are accounted high reliable (α = 0.8499), which indicating that (Specific) questionnaire could be applicable for the sampling population, and this confirms indirectly the sufficiency of the sample size that are selected to study the phenomenon. Pilot study has shown high reliabilities are accounted by inter and intra examiner (s).  

Results: The findings of the study indicated that (SHR-QoL)  for the studied patients are assigned that the observing responses were at a moderate response generally, and they are accounted for contents of studied questionnaire's main domains (Moderate, High, (Emotions, Body Hair, Weight, Infertility, and Menstrual Problems). In addition to that, relationships are accounted between an overall (SHR-QoL) redistributed by (under/upper) cutoff point regarding percentile global mean of score (PGMS) and anthropometric variables (BMI, and WHR), as well as socio-economic status of the studied patients.

Conclusion: A (PCOS) are formed a truly health problems associated with patients "Emotions, Body Hair, Weight, Infertility, and Menstrual Problems" aspects, so that patients having go down concerning (SHR-QoL), since all of studied items regarding SHR-QoL are accounted a moderate border to low evaluation, with (PGMS=51.47%), as well as weak relationships with no significant at P>0.05 are accounted between SHR-QoL and some unrelated variables, such as: anthropometric variables and socio-economic status, and according to that, it could be conclude that studied questionnaire could be take a broad view on studied target population even though differences with patients unrelated variables indeed.
Impact of Normal and Overweight Pregnant Women upon Pregnancy Complications In Al-Nasiriya Hospitals: Comparative Study
Authors: Rashed Sara , Ali Rabea
Published: March 2022

Abstract: Maternal obesity is a major risk for both the mother and the fetus, and it is considered an obstetrical risk factor that leads to a high incidence of complications, as well as an increased risk of many adverse pregnancy outcomes.
Objectives: To assess the impact of overweight pregnant women upon pregnancy complication at Al-Nasiriya city.
Methodology: A descriptive analytic study was conducted from January11th, 2021 to march 18th, 2021 at Al-Nasiriya city Hospitals for Maternity and Children on (88) pregnant women who are attending  Al-Nasiriya city Maternity Hospitals, (44) were overweight and (44) normal weight pregnant women. A non–probability (Purposive sample) was used to select the participants of study sample, a questionnaire was used as a tool to collect data content, validity was determined through reviewing it by (16) experts in different fields. Descriptive and inferential statistics were used to analyze the data.
Results: The result of study revealed that (34.1%) (36.4%) of study sample aged (26-30) years in normal, and overweight pregnant respectively. The study results clarifies the previous and current body mass index among normal weight pregnant women (100% & 95%) respectively, while in overweight (63.6%) overweight previously and (65.9%) obesity class (I) at current. the impact of weight upon pregnancy outcomes; the findings indicates that weight has significant impact up on outcomes related to pregnancy, at p-value= 0.007, while there is no impact has been reported among group of normal weight pregnant women.
Conclusion: The study concluded that overweight impact upon outcomes related to pregnancy, while there is no impact has been reported among group of normal weight pregnant women.
Recommendations: Increased physical activity and knowledge of healthy eating habits among pregnant women as part of primary health care center initiatives to reduce obesity in women.
Evaluation of micronutrients and vitamins in patients diagnosed with osteoarthritis
Authors: Oyakhire Fidelis , Abiodun Emokpae Mathias , Ajileye Samuel Adeola , Egho Eseoghene Valentine , Osaro Enehizena , Benjamin Ibhenbisa Ighedose , Asiriuwa Irabonosa , Ekoh-Jolly Adebukola Adisa , Aneke Nnamdi Bede
Published: March 2022

Objective: Osteoarthritis (OA) is a degenerative joint disease, a leading cause of pain and disability worldwide. The hallmark of OA is pathological changes of the joint structure, such as cartilage erosion and synovial inflammation. The study aimed to evaluate the micronutrients and vitamins in patients diagnosed with osteoarthritis (OA) in Edo State, Nigeria.
Material and Methods: A total of 300 patients comprising one hundred and fifty OA subjects and 150 non-osteoarthritis subjects were recruited for this study. The levels of micronutrients (Ca, Cu, Zn, Se ) were analyzed using AAS, while Vitamin D and K were measured using HPLC and spectrophotometer, respectively.
Results: The levels of copper, zinc, calcium, and vitamin K were significantly lower (p<0.05) except vitamin D (p>0,05) among osteoarthritis than non-osteoarthritis subjects. The selenium level was markedly higher in osteoarthritis than non- osteoarthritis subjects (p<0.05). The levels of trace elements were positively correlated with vitamin D, selenium(r= 0.23, p<0.05), calcium(r= 0.35, p<0.05), copper( r= 0.09, p>0.05). Blood levels of vitamin D, K, and zinc were negatively correlated with age. Vitamin D(r= -0.01, p>0.05), vitamin K(r = -0.02, p>0.05) and zinc(r = - 0.01, p>0.05).
Conclusion: Exposure to free radicals may be a predisposing factor to impaired synthesis of antioxidants that might be involved in the mechanical induction of osteoarthritis. Therefore, it is believed that strict metabolic control delays the development of late complications in osteoarthritis (OA). Therefore, adequate supplementation of trace elements and vitamins (D, K) in diet should be encouraged to lower the risk associated with osteoarthritis.