bluuebunny/crossref_metadata_2025 huggingface dataset:
Modifiable Arial Unit Problems for Infectious Disease Cases Described in Medicare and Medicaid Claims, 2016-2019
Authors: Williams Nick
Published: March 2024

Introduction: Modifiable Arial Unit Problems are a major source of spatial uncertainty, but their impact on infectious diseases and epidemic detection is unknown.
Methods: CMS claims (2016-2019) which included infectious disease codes learned through SNOMED CT were extracted and analyzed at two different units of geography; states and ‘home to work commute extent’ mega regions. Analysis was per member per month. Rolling average above the series median within geography and agent of infection was used to assess peak detection. Spatial random forest was used to assess region segmentation by agent of infection.
Results: Mega-regions produced better peak discovery for most, but not all agents of infeciton. Variable importance and Gini measures from spatial random forest show agent-location discrimination between states and regions.
Conclusions: Researchers should defend their geographic unit of report used in peer review studies on an agent-by-agent basis.
Experimental Studies of Heat Resistance and Compressive Strength of Heat-Resistant Concrete
Authors: Apshikur Baitak , Goltsev Anatoly Grigoryevich , Alimkulov Murat Mametkulovich , Rakhymberdina MarzhanYessenbekovna , Chernavin Valeriy , Aitkazin Ayazhan
Published: March 2024

The research purpose of the work is to extend the service life by experimental study of the performance of the liquid-layer furnace. Here, instead of large and small aggregates, the effect of the use of secondary refractory substances in reducing the cost of the concrete mixture is studied. The value of the study is to prove that heat-resistant concrete meets the technological requirements of a liquid-layer furnace, as well as experimental confirmation of the possibility of using secondary refractory materials as heat-resistant concrete aggregates. To solve this problem, it was proposed to replace the traditional method of facing the boiling floor furnaces (Fireclay brick of the SHB brand) with a monolithic concrete version. Considering that the technological feature of the boiling layer of the furnace is a high temperature up to 1000°C and an aggressive environment that causes SO3 gaseous sulfur, one of the well-known types of heat-resistant concretes, the sodium-infused liquid glass concrete type is selected as the base, and instead of cement, it is recommended to use liquid glass with low thermal conductivity, such as a material in the amorphous phase and a glass-layered composite viscous substance.
Messenger Rna Covid-19 Vaccination in Brazil: Uncertain Benefits and Risks Should Lead to Informed Choice by Health System Users, and Not to Imposition
Authors: Neves Fabricio Souza
Published: March 2024

Purpose. In 2024, COVID-19 vaccination became mandatory in Brazil for children aged 6 months to 4 years. In Brazil, the product available for this purpose is the Pfizer BNT162b2 Messenger RNA COVID-19 Vaccine, whose potential risks related to long-term human genomic changes are still uncertain compared to immunizations based on other platforms.
Methods. the epidemiology of Severe Acute Respiratory Syndrome was evaluated in Brazil, in the years 2022 and 2023, in children aged 6 months to 4 years, based on available public data.
Results. The number needed to treat (NNT) with BNT162b2 to prevent one death from COVID-19 in this age group can range from 208,856 to 548,246. The number needed to harm (NNH) to cause a vaccine-associated death can range from 42,373 to 909,090.
Conclusions. The results of this study indicate a borderline short-term risk/benefit ratio of BNT162b2 vaccine for the Brazilian population aged 6 months to 4 years. Given that there is no clear benefit from its mandatory use in this age group and the uncertainty regarding potential risks to human health in the long term due to possible retroposition (reverse transcription) with incorporation into the genome of parts of the genetic sequence introduced into humans as RNA exogenous by BNT162b, it is recommended that its use should not be mandatory and that vaccines based on other platforms should remain available, ensuring the right to informed choice by the health system users.
Prevalence and epidemic pattern of ecdemic multidrug-resistant tuberculosis during 2012- 2022 in Hangzhou, China
Authors: Li Qingchun , Wu Yifei , Cheng Qinglin , Lu Min , Huang Yinyan , Bai Xuexin , Jia Qingjun , Fang Zijian , Ai Liyun , Jiang Nan , Lao QiuFeng , Xie Li , Chen Junfang
Published: March 2024

Background
To assess the prevalence and epidemic pattern of multidrug-resistant (MDR) tuberculosis in Hangzhou City, Zhejiang Province, China during 2012–2022.
Methods
All the TB cases undergoing drug susceptibility testing (DST) during 2012–2022 were included in this study. De-identified information was extracted from the electronic database Tuberculosis Information Management System (TBIMS) for analysis of drug resistance prevalence in Hangzhou and ecdemic Multidrug-resistant TB (MDR-TB) which originated from other regions. Chi-square tests were used to compare drug resistance rates between different groups, while Chi-square tests for trend were used to evaluate the change of drug resistance rates over the years of 2012–2022. The sources and destinations of ecdemic MDR-TB were illustrated using a Sankey diagram.
Results
Of 21,127 cases included in this study, 1119 (5.3%) were MDR. A significant decline in MDR-TB rates was observed during 2012–2022. There was a significant difference in MDR-TB rates among immigrant population and local residents in Hangzhou City. Of 1119 MDR-TB cases, 515(46%) were ecdemic MDR-TB cases, of which 277(53.8%) were from other parts of Zhejiang Province and 238(46.2%) were from other provinces in China. Anhui, Jiangxi and Sichuan were among top three provinces which were the source of ecdemic MDR-TB cases. Three districts including Xiaoshan, Shangcheng and Linping districts had the most cases in Hangzhou. The proportion of ecdemic MDR-TB cases in Binjiang, Xiaoshan, Qiantang and Linping districtalso exceeded 30% of total cases.
Conclusions
MDR-TB prevalence has been declining in Hangzhou. Migrant population contributed to a significant portion of cases in Hangzhou. Interventions should be tailed to local and migrant residents.
Dynamic responses analysis of submerged floating tunnel under impact load
Authors:   State Key Laboratory of Coastal and Offshore Engineering, Dalian University of Technology, Dalian 116024, China, Wang Ming , Qiao Dongsheng , Zhou Xiangbo , Tang Guoqiang , Lu Lin , Ou Jinping
Published: March 2024

Submerged floating tunnel (SFT) may be subjected to sudden impact loads such as submarine and shipwreck. Besides the local damage caused by impact, the overall transient dynamic response may also affect its driving safety. Based on the dynamic impact finite element software, the full-length model, and the locally truncated accurate model with solid element of the SFT are established respectively. By applying different spring stiffness constraints on the boundary of the truncated model, its first three modes are consistent with the full-length model, thus their dynamic characteristics are basically the same. The truncated model is further used to simulate the impact of a massive object on the SFT under different impact velocities, impact mass, impact angles and impact positions. The velocity and mass of the impact object have positive influences on the peak contact force, the displacement amplitude of the tube and the length of the damaged area. When the impact angle is perpendicular to the SFT tube, the contact force, displacement amplitude and the damaged area are the largest. The change of the impact position has little effect on the contact force and the damage area, but it will affect the distribution of displacement amplitude.
Integrated Serum Pharmacochemistry and Network Pharmacological Analysis
Used To Explore Possible Anti-Aging Mechanisms of the Ginsenosides
Authors: Li Jing , Li Ruigang , Yang Qing , Liu Xiaoran , Qu Xiaobo , Li Na
Published: March 2024

Background::

Although constitutive ginsenosides are credited with ginseng's remarkable
anti-aging efficacy, the mechanism of action and bioactive components of ginsenosides are
unclear.

Objective::

The goal of the study was to examine the effect of ginsenosides on D-galactose (Dgal)-
induced aging in rats and to figure out the underlying molecular mechanism using serum
pharmacochemistry and network pharmacology.

Methods::

Using behavioral, biochemical indexes, and histological analysis, ginsenosides were
evaluated for their anti-aging effects in rats induced by D-gal, and effective ingredients absorbed
in the blood were examined by ultra-performance liquid chromatography quadrupole time of flight
coupled with mass spectrometry (UPLC-Q/TOF-MS) before being subjected to network pharmacology
analysis.

Results::

As well as improving spatial learning and memory skills, Ginsenosides are known to
regulate malondialdehyde (MDA), glutathione peroxidase (GSH-Px), total antioxidant capacity
(T-AOC) and superoxide dismutase (SOD) activity. In addition, it improved the ultrastructure of
neurons in D-gal-induced rats' hippocampus. Seventy-four absorption components and metabolites
of ginsenosides were identified in aging rat serum. According to a network pharmacology study,
ginsenosides have anti-aging properties by modulating the phosphatidylinositol 3-kinase/protein
kinase B (PI3K/AKT) and mitogen-activated protein kinases (MAPK) signaling pathways.

Conclusion::

The potential mechanisms of the anti-aging effect of ginsenosides involve multiple
components, targets, and pathways. These findings serve as a foundation for further research into
the processes behind ginsenoside's anti-aging impact.
Nanotheranostics: A Cutting-Edge Technology for Cancer Management
Authors: Dash Shwetapadma , Swain Shasank Sekhar , Khuntia Auromira , Dutta Sneha , Sahoo Sanjeeb Kumar
Published: March 2024

Cancer is the second-leading cause of death in the 21st century, where early detection
and appropriate therapeutic interventions are two components essential for effective cancer
management. Despite the availability of several conventional diagnostics and therapeutic agents,
cancer mortality rates are rising due to an increase in the frequency of recurrence and metastasis
in cancer patients. Therefore, tremendous efforts have been expended to address this significant
clinical issue and improve therapeutic efficacy. In this regard, nanotheranostic is a multipotential
single platform for both cancer diagnosis and treatment through enhanced aqueous solubility and
bioavailability of the encapsulated agent, stimulus responsiveness, tumor-specific targeting ability,
precise tumor imaging, and real-time drug delivery. Nonetheless, the translational success of
nanotheranostic platforms is still in its infancy and requires more extensive research in the context
of tumor heterogeneity, safety profile, and regulatory issues, which pose one of the largest
technological limitations. The present review summarizes different nanotheranostic platforms
and nanotheranostic candidates in clinical trials (AGuIX®
, NBTXR3, Ferumoxtran, MM-398,
EndoTAG-1, etc.), along with disadvantages and challenges to improving cancer diagnosis and
treatment. Overall, the concept, platform, and technical knowledge of nanotheranostics are really
helpful to academic and pharmaceutical researchers.
ZNF695, A Potential Prognostic Biomarker, Correlates with Im mune
Infiltrates in Cervical Squamous Cell Carcinoma and Endoce rvical
Adenocarcinoma: Bioinformatic Analysis and Experimental Verification
Authors: Ding Xiaojuan , Wan Ailing , Qi Xin , Jiang Ke'er , Liu Zhao , Chen Buze
Published: March 2024

Background::

The role of Zinc Finger Protein 695 (ZNF695) is unclear in cervical squamous
cell carcinoma and endocervical adenocarcinoma (CESC).

Objective::

The objective of this study was to conduct a comprehensive analysis and experimental
validation of ZNF695 in CESC.

Methods::

The study investigated the expression of ZNF695 in both pan-cancer and CESC, utilizing
data from The Cancer Genome Atlas (TCGA) database to assess its diagnostic value. The present
study investigated the association between ZNF695 expression levels and clinical characteristics,
as well as prognosis, in patients with CESC. The study explored potential regulatory networks
involving ZNF695, including its association with immune infiltration, immune score, stemness
index based on mRNA expression (mRNAsi), and drug sensitivity in CESC. We explored the
expression of ZNF695 in CESC single cells. ZNF695 expression was validated using GSE29570.

Results::

ZNF695 was found to be aberrantly expressed in pan-cancer and CESC. There was a significant
correlation observed between an elevated level of ZNF695 expression in patients with
CESC and histological grade (p = 0.017). Furthermore, a strong association was found between
high ZNF695 expression in CESC patients and poorer overall survival (OS) (HR: 1.87; 95% CI:
1.17-3.00; p = 0.009), Progression-free Survival (PFS) (HR: 1.86; 95% CI: 1.16-2.98; p = 0.010),
and Disease-specific Survival (DSS) (HR: 1.98; 95% CI: 1.15-3.42; p = 0.014). The expression of
ZNF695 in CESC patients (p = 0.006) was identified as an independent prognostic determinant.
ZNF695 was associated with steroid hormone biosynthesis, oxidative phosphorylation, and so on.
ZNF695 expression correlated with immune infiltration, immune score, and mRNAsi in CESC.
ZNF695 expression significantly and negatively correlated with AICA ribonucleotide, BIX02189,
QL-XI-92, STF-62247, and SNX-2112 in CESC. ZNF695 gene was upregulated in CESC tissues
and cell lines. ZNF695 was significantly upregulated in the CESC cell lines.

Conclusion::

ZNF695 may be a potential prognostic biomarker and immunotherapeutic target for
CESC patients.
Predictors of Emboli in Mechanical Thrombectomy for Anterior
Circulation Stroke
Authors: Kwon Yongho , Yi Ho Jun , Shin Dong-Seong , Kim Bum-Tae
Published: March 2024

Objective:

Emboli commonly occurs in mechanical thrombectomy (MT). The objective
of this study was to analyze predicting factors of emboli after MT.

Methods:

Patients who underwent MT with successful reperfusion for anterior circulation occlusion
were enrolled. Emboli included distal emboli at digital subtraction angiography (DSA) and
unexpected embolic infarct on diffusion-weighted image (DWI) without distal emboli at DSA.
Baseline characteristics, procedural details, angiographic outcomes, and clinical outcomes were
reviewed. Multivariable analyses were performed to evaluate predictive factors for the occurrence
of emboli.

Results:

Of 601 patients, 149 (24.8%) patients had distal emboli at DSA, and 169 (28.1%) patients
had unexpected embolic infarction on DWI even without distal emboli at DSA. A total of
318 (52.9%) patients were enrolled in the embolic group, and 283 (47.1%) patients were assigned
to the non-embolic group. In multivariate analysis, larger microcatheter (OR 1.26, 95%
CI 1.12–1.94; p = 0.047), clot passage (OR 1.33, 95% CI 1.07–1.87; p = 0.041), use of balloon
guide catheter (BGC) (OR 0.70, 95% CI 0.52–0.92; p = 0.014), early ballooning of BGC (OR
0.68, 95% CI 0.50–0.90; p = 0.009), and longer stent retriever (OR 0.72, 95% CI 0.54–0.90; p =
0.029) were associated with occurrence of emboli.

Conclusion:

MT with only a stent retriever, use of a larger microcatheter, and clot passage
might increase the risk of emboli. In contrast, contact aspiration thrombectomy, use of BGC,
early ballooning of BGC, and use of longer stent retrievers could reduce the chance of emboli.
Ginsenoside Rg3: A Review of its Anticancer Mechanisms and Potential
Therapeutic Applications
Authors: Wu Lei , Bai Lin , Dai Wenshu , Wu Yaping , Xi Pengjun , Zhang Jie , Zheng Lily
Published: March 2024

Background:

Traditional Chinese Medicine (TCM) has a long history of treating various
diseases and is increasingly being recognized as a complementary therapy for cancer. A
promising natural compound extracted from the Chinese herb ginseng is ginsenoside Rg3, which
has demonstrated significant anticancer effects. It has been tested in a variety of cancers and tumors
and has proven to be effective in suppressing cancer.

Objective:

This work covers various aspects of the role of ginsenoside Rg3 in cancer treatment,
including its biological functions, key pathways, epigenetics, and potential for combination therapies,
all of which have been extensively researched and elucidated. The study aims to provide a
reference for future research on ginsenoside Rg3 as an anticancer agent and a support for the potential
application of ginsenoside Rg3 in cancer treatment.
Federated Learning-based Black Hole Prevention in the Internet of Things
Environment
Authors: Karunakaran Martin Victor , Jebadurai Immanuel Johnraja , Paulraj Getzi Jeba Leelipushpam
Published: March 2024

Background and Objective::

The Internet of Things offers ubiquitous automation of
things and makes human life easier. Sensors are deployed in the connected environment that sense
the medium and actuate the control system without human intervention. However, the tiny connected
devices are prone to severe security attacks. As the Internet of Things has become evident in
everyday life, it is very important that we secure the system for efficient functioning.

Method::

This paper proposes a secure federated learning-based protocol for mitigating BH attacks
in the network.

Results::

The experimental result proves that the intelligent network detects BH attacks and segregates
the nodes to improve the efficiency of the network. The proposed techniques show improved
accuracy in the presence of malicious nodes.

Conclusion::

The performance is also evaluated by varying the attack frequency time.
Risk Assessment Model of Emergency Lane Change Behavior for
Intelligent Vehicles
Authors: Yixuan Feng , Huanhuan Zhang , Minjie Yao , Hongchao Wu
Published: March 2024

Background::

The condition that vehicles are prone to skidding during emergency lane
changing, an anti-rollover constraint is added to the trajectory planning.

Methods::

The evaluation index is constructed by the lateral load transfer rate LTR, so as to put
forward a seventh-order polynomial trajectory planning method considering the anti-rollover. It
improves the safety and stability of the planned trajectory of the intelligent vehicle when changing
lanes in an emergency. The risk assessment index under different emergency lane changing modes
is obtained through simulation tests, the phase plane method is used to classify the risk level and
formulate a reasonable risk decision-making mechanism. A patented model for risk assessment
considering the risk of instability is designed.

Results::

The tests conducted on a low-friction road show that when the risk assessment factor is in
the range of the steering lane change mode intervals, the steering controller maneuvers the vehicle
to make an emergency lane change with a seventh-order polynomial trajectory.

Conclusion::

The small fluctuation of the LTR verifies the feasibility of the model.
Natural Biomaterials: An Essential Element for in vitro Disease Modeling
Authors: Gayan Sukanya , Chitnis Malhar , Kshirsagar Disha , Dey Tuli
Published: March 2024

In-depth analysis of human diseases, specifically emergent noncommunicable ones, needs to be carried out to understand the molecular mechanism
and develop sustainable therapeutics. Animals such as small rodents and canines are
frequently used as models for clinical trials. However, recent evidence suggests the
inappropriateness of such in vivo models for human diseases. A new class of humanrelevant platforms needs to be established to resolve the issues surrounding the failure
of potential drug candidates over the last decades. The development of human-relevant
in vitro models must abide by the 3R’s principles for biomedical research. Modeling
diseased tissue requires appropriate matrices such as scaffold, hydrogel,
electrospinning mats, and others to mimic the strength and mechanics of the tissue in
question. Biodegradable biomaterials from natural sources such as plants and animals
are already used widely for tissue engineering, and regenerative medicines can be
repurposed to develop a human-relevant disease model. Here we will discuss the
current status of such in vitro models for a few highly fatal non-communicable diseases
like cardiomyopathy, cancer, neuropathy, and others.
Bibliometric review of service learning on civic education
Authors:   Civic Education, Faculty of Social Studies Education, Universitas Pendidikan Indonesia, Bandung, Indonesia, Rahman Ikman Nur , Budimansyah Dasim ,   Civic Education, Faculty of Social Studies Education, Universitas Pendidikan Indonesia, Bandung, Indonesia, Suryadi Karim ,   Civic Education, Faculty of Social Studies Education, Universitas Pendidikan Indonesia, Bandung, Indonesia, Sundawa Dadang ,   Civic Education, Faculty of Social Studies Education, Universitas Pendidikan Indonesia, Bandung, Indonesia
Published: March 2024

The aim of service learning is to give students a learning experience that is connected to real-world situations and progresses over time while also helping the community. Service learning is a way of teaching that connects what students learn in lectures and theories from the classroom to the community's needs and situation. This study plans to look at and summarize the growing number of studies on using service learning in teaching about civic duties to bring new ideas into civic education. The study uses the VOSviewer tool for a bibliometric analysis, which is a way to study information on service learning in civic education using data. The data was gathered from the Scopus database using keywords like "service-learning," "citizenship," "civic," and "education." The search found 90 articles related to the topic, published between 1997 and 2023. The findings indicate that research on service learning in civic education started in 1997, with significant increases in 2010 and 2022. The early research was more about expressing ideas and theories. The study suggests that service learning can be a creative way to teach civic education.
Translation Effectiveness of Offset Heart Rate Biofeedback as a Mindless Intervention for Alcohol Craving Among Risky Drinkers: Controlled Experiment (Preprint)
Authors: Zhao Yiran , Arora Jatin , Tao Yujie , Miller Dave B , Adams Alexander T , Choudhury Tanzeem
Published: March 2024

BACKGROUND

Digital and wearable intervention systems promise to improve how people manage their behavioral health conditions by making interventions available when the user can best benefit from them. However, existing interventions are obtrusive because they require attention and motivation to engage in, limiting the effectiveness of such systems in demanding contexts, such as when the user experiences alcohol craving. Mindless interventions, developed by the human-computer interaction community, offer an opportunity to intervene unobtrusively. Offset heart rate biofeedback is an iconic type of mindless intervention powered by entrainment and can mitigate the physiological and psychological response to stressors.

OBJECTIVE

This work aimed to characterize the translational effectiveness of offset heart rate biofeedback on cue-elicit alcohol craving among risky drinkers.

METHODS

We conducted an out-of-lab, between-group, controlled experiment with 26 participants who performed harmful or hazardous drinking. The control group served as negative control and received no intervention, while the experimental group received offset heart rate biofeedback during alcohol exposure and recovery. We elicited alcohol cravings through a series of alcohol cues, including performing mental imagery, viewing alcohol images, and sniffing alcohol. We measured the physiological response to alcohol (ie, heart rate variability), self-reported craving, and self-reported anxiety. We constructed linear mixed-effects models to understand the effect of intervention during alcohol exposure and alcohol recovery after exposure. Following the linear mixed effect model, we conducted pair-wise comparisons for measures between the control and experimental groups.

RESULTS

We found that offset heart rate biofeedback significantly reduced the increase in heart rate variability (P=.01 and P=.052) and self-reported craving (P=.04 and P=.02) in response to alcohol cues. Participants’ anxiety was not affected by either the alcohol cues or the offset heart rate biofeedback.

CONCLUSIONS

Offset heart rate biofeedback has the potential to immediately and unobtrusively mitigate cue-elicit alcohol craving among risky drinkers. The results of this study opened new opportunities for digital and wearable interventions to mitigate alcohol craving, either as wellness apps for risky drinkers or as digital prescriptions and integration with sensing systems for people with alcohol dependency.
Current Status of ChatGPT Use in Medical Education: Potentials, Challenges, and Strategies (Preprint)
Authors: Xu Tianhui , Weng Huiting , Liu Fang , Yang Li , Luo Yuanyuan , Ding Ziwei , Wang Qin
Published: March 2024

UNSTRUCTURED

ChatGPT, a generative pretrained transformer, has garnered global attention and sparked discussions since its introduction on November 30, 2022. However, it has generated controversy within the realms of medical education and scientific research. This paper examines the potential applications, limitations, and strategies for using ChatGPT. ChatGPT offers personalized learning support to medical students through its robust natural language generation capabilities, enabling it to furnish answers. Moreover, it has demonstrated significant use in simulating clinical scenarios, facilitating teaching and learning processes, and revitalizing medical education. Nonetheless, numerous challenges accompany these advancements. In the context of education, it is of paramount importance to prevent excessive reliance on ChatGPT and combat academic plagiarism. Likewise, in the field of medicine, it is vital to guarantee the timeliness, accuracy, and reliability of content generated by ChatGPT. Concurrently, ethical challenges and concerns regarding information security arise. In light of these challenges, this paper proposes targeted strategies for addressing them. First, the risk of overreliance on ChatGPT and academic plagiarism must be mitigated through ideological education, fostering comprehensive competencies, and implementing diverse evaluation criteria. The integration of contemporary pedagogical methodologies in conjunction with the use of ChatGPT serves to enhance the overall quality of medical education. To enhance the professionalism and reliability of the generated content, it is recommended to implement measures to optimize ChatGPT’s training data professionally and enhance the transparency of the generation process. This ensures that the generated content is aligned with the most recent standards of medical practice. Moreover, the enhancement of value alignment and the establishment of pertinent legislation or codes of practice address ethical concerns, including those pertaining to algorithmic discrimination, the allocation of medical responsibility, privacy, and security. In conclusion, while ChatGPT presents significant potential in medical education, it also encounters various challenges. Through comprehensive research and the implementation of suitable strategies, it is anticipated that ChatGPT’s positive impact on medical education will be harnessed, laying the groundwork for advancing the discipline and fostering the development of high-caliber medical professionals.
Penilian Risiko Paparan Debu Silika Terhadap Pekerja di Industri Pengolahan Bijih Mineral
Authors: Putro Edi Karyono , Kusnadi Saskia Nur Fadhilah , Susanto Arif , Zannah Miftahul , Mahalisa Rizky , Manuel Anthony Andorful
Published: March 2024

Latar   Belakang: Proses industri bijih mineral menghasilkan debu silika yang berbahaya bagi kesehatan pekerja. Komposisi debu seperti silika bersifat karsinogenik dan dapat melebihi Nilai Ambang Batas (NAB).Tujuan: Penelitian ini bertujuan untuk menganalisis risiko paparan debu silika terhadap tiga jenis sistem rotasi kerja di industri pengolahan bijih mineral.Metode: Metode yang digunakan adalah metodologi kuantitatif Analisis Risiko Kesehatan Lingkungan (ARKL) dengan menghitung nilai Excess Cancer Risk (ECR) sesuai dengan kondisi jalur paparan, agen risiko, serta sistem rotasi kerja. Analisis dilakukan pada paparan debu silika tahun 2020 dan 2021. Metode pengambilan sampel debu silika menggunakan pengukuran yang ditetapkan oleh OSHA-ID142.Hasil: Konsentrasi debu silika pada proses industri bijih mineral melebihi NAB . Tahun 2020 paparan debu silika berkisar antara 0.41-2.99 μg/m3, tetapi mengalami penurunan pada 2021 menjadi 0.05-1.16 μg/m3. Baik pada tahun 2020 maupun 2021, perhitungan ECR berada dalam rentang aman yang ditetapkan oleh United States of Environmental Protection Agency (US EPA).  Hasil perhitungan ECR yaitu di bawah 10-4 untuk ketiga sistem rotasi kerja di semua lokasi pengukuran.Kesimpulan: Konsentrasi debu silika diatas NAB tetapi evaluasi ARKL menunjukkan terdapat risiko karsinogenik terhadap tiga jenis rotasi kerja berada di bawah batas aman, sehingga tidak membahayakan pekerja. Industri bijih mineral perlu terus meningkatkan pengendalian debu untuk mengurangi konsentrasi debu silika dibawah NAB.
Analisis Tantangan Kesiapan Implementasi Rekam Medis Elektronik di Puskesmas Kota Padang
Authors: Siswati Sri , Ernawati Tuty , Khairunnisa Muthia
Published: March 2024

Latar   Belakang: Puskesmas merupakan salah satu fasilitas kesehatan yang wajib melaksanakan Rekam Medis Elektronik (RME) paling lambat 31 Desember 2023 melalui Permenkes Nomor 24 Tahun 2022 tentang Rekam Medis. Namun, faktor kesiapan SDM menjadi tantangan dalam pengimplementasiannya, seperti kurangnya pengetahuan dan skill komputer.Tujuan: Penelitian ini bertujuan untuk mengetahui faktor dan hambatan yang mempengaruhi kesiapan tenaga kesehatan dalam menerapkan RME di Puskesmas.Metode: Penelitian mixed-method dengan model sequantial explanatory dilakukan pada Mei sampai Oktober 2023 di 23 Puskesmas Kota Padang. Tahap penelitian kuantitatif dilakukan secara cross-sectional terhadap 69 sampel, yaitu dokter, perekam medis, dan perawat. Penelitian kualitatif dilakukan terhadap 46 informan, yaitu 23 kepala puskesmas dan 23 perekam medis dengan cara purposive sampling.Hasil: Dari 69 responden, hanya 33 (47,8%) dengan 39,4% diantaranya adalah perekam medis yang siap menggunakan RME. Tingkat pendidikan, pengalaman kerja, pengetahuan, dan persepsi mempengaruhi signifikan terhadap kesiapan tenaga kesehatan melaksanakan RME. Penyebab belum siapnya tenaga kesehatan dalam melaksanakan RME adalah pelatihan RME tidak diberikan ke seluruh tenaga dan  kurangnya keterampilan komputer dan pengetahuan tentang RME.Kesimpulan: Tidak semua tenaga kesehatan siap menerapkan RME karena pelatihan hanya didapat oleh perekam medis sehingga perlu pelatihan untuk meningkatkan pengetahuan RME dan meningkatkan keterampilan komputer bagi seluruh petugas yang menggunakan RME dalam pelayanannya.
Peran Kearifan Lokal Suku Bajau di Desa Torosiaje – Gorontalo dalam Menghadapi Ancaman Bencana Ekologis dan Implikasinya Terhadap Ketahanan Lingkungan Wilayahm Menghadapi Ancaman Bencana Ekologis
Authors: Setyaningsih Emi
Published: March 2024

ABSTRACT The purpose of this study is to analyze the role of Bajau tribal wisdom in dealing with ecological disasters and their implications for regional environmental resilience. Ecological disaster is a problem in Torosiaje region, Gorontalo. The archipelago actually has wisdom that is empirically proven to be able to minimize environmental damage caused by human exploitation. Unfortunately, this wisdom is starting to be abandoned because it is considered unscientific and outdated.This research is literature research with  hermeneutic method. This method is used to identify the essential meaning contained in the object of research, namely the local wisdom possessed by the Bajau Tribe related to their views on the relationship between nature and humans, then how the knowledge system based on that worldview is able to provide real implications for environmental resilience in the Torosiaje area in facing the threat of ecological disasters.        The results of this study indicate that the local wisdom of the Bajau Tribe manifested in the knowledge system and attitudes of the Bajau Tribe in managing the natural environment in the sea can strengthen environmental resilience in the face of the threat of ecological disasters. The strategy taken to strengthen environmental resilience is to synergize the Bajau knowledge system with science in the form of marine resource conservation and marine tourism activities. The environmental resilience of the Torosiaj region is also supported by community participation and legal political instruments with an environmental paradigm
Investigating the Effect and Role of Documenting the Inlay Work of Entrance Doors with the Aim of Historical Analysis and Identifying the Style of Inlay Work of the Qajar Period
Authors: Arab Samira
Published: March 2024

Aims: Inlay is one of the methods of decorating the surface of wooden objects, which started from Al-Muzaffar. The Qajar period was one of the most important historical periods that important role in the innovation of inlay. Due to the closeness of the Qajar to the contemporary Period and as a result of the numerous works left from this period in comparison with the previous periods, there is more knowledge about this period. In this research, inlay work has been considered as a part of the architectural decorations and the entrance door of Zeyd Imam Zadeh and the protected entrance door in the National Museum of Iran. The Qajar period was the continuation of the Safavid and many influences in the remaining works. Many researches have been done on the Qajar architectural decorations, but so far, no independent and comprehensive research has been done on inlay as a part of architectural decorations.Methods: The method used is according to the practical purpose and the method of study is according to the descriptive-analytical. The method of collecting information was in the form of field and library research.Findings: The studies conducted indicate that the identification of key components such as the Marquetry-inlay and Arrangement of Inlay by Gereh method that play a very important role in the expert analysis of the style of the work. Also, documenting and analyzing the obtained specialized information helps to improve the knowledge of protection and preservation of works.Conclusion: The present research has played an effective role in analysing the components of Qajar inlay innovation and its place in the studied works, and also the documentation information obtained helps to improve the knowledge of preservation and preservation of works.
Aprendizaje autodirigido en el Bachillerato en Línea Pilares
Authors: Cázares Mondragón Roberto
Published: March 2024

En este video por invitación, el estudiante de mayor promedio (9.8) de la primera generación del Bachillerato en Línea Pilares, del Gobierno de la Ciudad de México hace un análisis de sus motivaciones, desafíos y estrategias de éxito al cursarlo. Describe sus sesiones de entre tres y cinco horas de estudio cada noche complementadas con la búsqueda de otras fuentes para ampliar y consolidar el conocimiento al día siguiente.
El programa de Fundación CASO para estudiantes sobresalientes
Authors: Valdez González Selene Itzel
Published: March 2024

En este texto se presenta, desde el punto de vista de una estudiante, la experiencia de cursar el Bachillerato a Distancia de la UNAM (B@UNAM) en el marco de su participación en la Fundación CASO, dedicada a apoyar el desarrollo de estudiantes sobresalientes. Se relata cómo se detectó que es una alumna sobresaliente, qué tipo de ajustes en la escolaridad se llevaron a cabo para completar la secundaria y el bachillerato en solo cuatro años, así como la organización que se tuvo para integrar actividades e intereses personales a su formación académica.
Derivaciones del uso de la Inteligencia Artificial (IA) en la preservación digital
Authors: Rodríguez Reséndiz Perla Olivia
Published: March 2024

La capacidad de generar datos es constante e imparable. Cada año producimos más información que el anterior y su preservación digital es un problema social que afrontan las instituciones de la memoria, entre las que destacan los archivos sonoros y audiovisuales. Ante esta situación, la gestión y el manejo de grandes volúmenes de información digital a través de la Inteligencia Artificial (IA) podría significar una alternativa, cuyas derivaciones deben ser analizadas desde diferentes perspectivas.
En este artículo se comparte una reflexión en torno al empleo de la IA en la preservación digital, cuya incorporación resulta paradójica. La IA ofrece oportunidades de mejora en los procesos documentales y, al mismo tiempo, podría derivar en consecuencias adversas. Para establecer las derivaciones de la IA en los archivos sonoros y audiovisuales, se realizó una investigación cualitativa. Como resultado, se advierten costos medioambientales, patrimoniales y sociales, cuyo impacto en la preservación digital debe ser considerado, a fin de proponer estrategias de mitigación.
Más de una década de cambio climático en Chile: análisis de las políticas domésticas
Authors: Lucas Garín Andrea
Published: March 2024

Chile ha avanzado desde los compromisos internacionales para ir desarrollando políticas climáticas, que son el objeto de este estudio. En particular, se revisan los hechos claves sobre cambio climático, para contextualizar las vulnerabilidades y los impactos del fenómeno, las percepciones que la sociedad chilena está teniendo al respecto, y su participación en el régimen internacional; para avanzar en la arquitectura climática que está conformada por la institucionalidad y los instrumentos de gestión, de modo de finalizar con un análisis de este escenario en clave jurídica, de modo de alcanzar reflexiones finales.
Cardiotoxicity of Doxorubicin in Acute Leukemia
Authors: Abdikhalimovna Amerova Dilafruz
Published: March 2024

Abstract: Doxorubicin, an anthracycline chemotherapeutic agent, is widely utilized in the treatment of acute leukemia due to its potent anti-neoplastic properties. However, its clinical utility is limited by the occurrence of dose-dependent cardiotoxicity, which may manifest as cardiomyopathy, heart failure, or arrhythmias. This review provides an overview of the mechanisms underlying doxorubicin-induced cardiotoxicity, including oxidative stress, mitochondrial dysfunction, and DNA damage. Additionally, it discusses risk factors predisposing patients to cardiotoxicity, such as cumulative dose, age, pre-existing cardiac conditions, and concomitant use of other cardiotoxic agents. Furthermore, this review highlights various strategies for the prevention and management of doxorubicin-induced cardiotoxicity, including the use of cardioprotective agents, cardiac monitoring protocols, and lifestyle modifications. Finally, future directions for research aimed at minimizing cardiotoxicity while preserving the antineoplastic efficacy of doxorubicin in acute leukemia treatment are discussed.
Analyzing the differences: U-dictionary and google translate's English-to-Indonesian speech translation
Authors: Budianto Suhartawan , Andharu Devito , Kartini Ratna
Published: March 2024

This study investigated the use of U-Dictionary and Google Translate in translating English Speech into the Indonesian language. This study aimed to test whether U-Dictionary outperforms Google Translate in translating English Speech into Indonesian. The true experimental design was applied to examine the result of the translation from U-Dictionary and Google Translate. Two raters assessed the translation result from U-Dictionary and Google Translate using a translation scoring rubric (In the "Equal Variances Assumed" section, the two-tailed significance value is 0.000, which is less than 0.05). The result showed that U-Dictionary didn’t outperform Google Translate in translating English Speech into Indonesian. On the contrary, Google Translate outperformed U-Dictionary Google Translate in translating English Speech into the Indonesian language. Here, the source language is English and the target language is Indonesian language. The result strongly suggests that Google Translate app is more effective than U-Dictionary in translating English to Indonesian in relating topics such as biography, daily life, and culture of certain community. The further research is expected to investigate the efficacy of Google Translate towards U-Dictionary in different scope of discourse like economic, politic, law, and etc. Moreover, the future research may compare among Machine Translation (MT) or among translation apps.
Early childhood development after COVID-19 through Kindergarten teachers' perceptions in Gangwon State
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Kim ji-won , Lee jung-pyo
Published: March 2024

Objectives This study investigated the status of early childhood development after COVID-19 based on teacher perception.
Methods To this end, 173 public and private Gindergarten teachers located in G-do were surveyed, and the collected data were analyzed through frequency analysis, multiple response analysis, independent sample T-test, variance analysis, and mean difference test using SPSS 21.0.
Results 81% of public and private Kindergarten teachers working in G Province recognized that COVID-19 had a significant impact on early childhood development, and the main factors affecting early childhood development were “wearing masks” and “social distancing.” Specifically, mask-wearing has caused direct difficulties in communication, social distancing, non-face-to-face distance learning, and the reduction in the number of Kindergarten attendance days. As a result, among the five Kindergarten curriculum areas, the areas that were most affected can be seen as the ‘communication domain’ and the ‘social relations domain’.
Conclusions The measures to support early childhood development suggested by this study include the operation of various programs in each area, strengthening early childhood-connected integrated education, and administrative support in terms of personnel, budget, and structure. In addition, it was suggested that longitudinal studies for preemptive and preventive policy support, community cultural studies to strengthen communication and cooperation among early childhood education officials, and basic research to secure policy independence of early childhood education institutions need to be activated.
The Mediating Effect of Letter Perception on the Relationship between Visual Perspective Taking, Inhibitory Control and Language Development in the Preschool Period
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Kim Jiny , Song Hana
Published: March 2024

Objectives The purposes of this study is to analyze the mediating effect of letter perception on the relationship between visual perception, inhibitory control and language development.
Methods The data were collected from 66 preschool students and their parents in Gyeonggi-do province. Including reliability analysis, technical statistics, correlation analysis, and stepwise multiple regression analysis were conducted using the SPSS 27.0. A three-step regression analysis was performed to verify the mediating effect.
Results As a result of this study, first, there was a significant correlation between visual view acceptance and all other variables, as well as between language development and letter perception. Second, the mediating effect of letter perception was significant in the relationship between visual perspective taking and language development.
Conclusions The results of this study suggest the necessity of improving visual perspective taking for language development. Also, it suggest the importance of educating language that helps improve letter perception in the preshool period.
Dietary characteristics and nutrient intake according to weight status among school-age children in Korea: Based on the 7th and 8th Korea National Health and Nutrition Examination Survey (2016-2019)
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Min Jinsil , Kye Seunghee
Published: March 2024

Objectives This study aims to determine the status of obesity and underweight among school-age children in Korea and to compare and analyze dietary characteristics and nutrient intake status according to weight status.
Methods Data from a total of 2,075 children aged 6 to 11 who participated in the 7th and 8th Korea National Health and Nutrition Examination Survey (KNHANES) conducted from 2016 to 2019 were used for analysis. The height and weight of participants were used to calculate body mass index (BMI). The participants were then classified into underweight, normal weight, and overweight/obese groups. Differences in socioeconomic and dietary characteristics for each weight group were analyzed. Energy, intake of the three main nutrients, rate of energy supply, nutrient intake ratio to dietary reference intake, and the ratio of those below the nutrient reference intake were calculated for each weight group.
Results Results indicated that 9.45% of male children and 10.74% of female children were underweight, while 20.57% of male children and 18.10% of female children were overweight/obese. The lower the parents’ education level, the higher the rate of overweight/obesity in children. Children who skipped breakfast more than five times a week had a higher rate of overweight/obesity than children who skipped breakfast less than five times a week. Compared to the underweight group, the overweight/obese group consumed more vegetables, meat, fish, and seafood but less fruit. The intake ratio to the estimated energy requirements (EER) was 97% in the underweight group and 102 to 108% in the normal and overweight/obese groups. The intake ratio of protein to the recommended intake (RI) was 144 to 166%, exceeding the protein reference intakes for all weight groups. The intake ratios of vitamin A and calcium to the RI were low at 73 to 74% and 63 to 69% in all weight groups, respectively.
Conclusions Thus, this study suggests that the government, community-related organizations, and schools should continue to cooperate to provide efficient intervention programs to manage the health and nutrition of obese and underweight children.
Mediation Effects of Interaction Styles in the Relationships Between Perceived Motivational Climate and Learning Attitude in Physical Education Class of Middle School Students
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Nam In Soo
Published: March 2024

Objectives The purposes of this study were to the mediation effects of interaction styles in the relationships between perceived motivational climate and learning attitude in physical education class of middle school students.
Methods The subjects of this study consisted of 323(boys 163, girls 163) middle school students. The data was collected by quota sampling method. The used instrument of this study were the Yoo(1997) for measuring motivation climate scale, the Hwang, Ahan, and Seo(2016) for measuring friend relationship and teacher-students relationship scale, and the Son, Kim, & Lee(2006) for measuring learning attitude scale. The data were analyzed by descriptive statistics, factor analysis, correlation analysis, and a structural equation model as a statistical method.
Results The results of this study was as follows. First, mastery climate positively influenced to teacher-students relationship and friend relationship, but performance climate positively influenced to friend relationship. Second, both mastery climate and performance climate positively influenced to learning attitude. Third, both teacher-students relationship and friend relationship positively influenced to learning attitude. Forth, there was partially mediates effect between mastery climate and learning attitude as a parameter fo the teacher-students relationship.
Conclusions The purposes of this study was confirmed that motivation climate had partially mediates effect on learning attitude through the teacher-students relationship.