bluuebunny/crossref_metadata_2025 huggingface dataset:
Individualized patient care and clinical outcomes in HIV/AIDS management
Authors: Eshiet Unyime I. , Njoku Chikosolu R.
Published: October 2023

Objectives:

Individualized care has the potential to significantly improve health outcomes in patients with chronic conditions. This study was aimed at evaluating the quality of individualized care and its impact on clinical outcomes in patients with the human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) receiving treatment in a resource-limited setting.

Materials and Methods:

The study was a cross-sectional prospective study carried out in the HIV/AIDS clinic of the University of Uyo Teaching Hospital, Nigeria. Data on the demographic and clinical details of the patients were obtained from patient’s case notes using a suitably designed, pre-piloted data collection instrument. Data on patients’ assessment of the quality of individualized care were obtained using a “Patient Assessment of Quality of Individualized Care for Chronic Illness Scale.” Quantitative data were analyzed using the IBM Statistical Product and Service Solutions version 25.0 computer package. Descriptive statistics was used to summarize data, whereas inferential statistics was used where applicable with statistical significance set at P < 0.05.

Results:

The overall mean patients’ satisfaction with individualized care score was 3.54 (standard deviation = ±0.86; max. = 5). The majority of the patients (271) had a documented viral load of <50 copies/mL, whereas 27% (109) of the patients had a recently documented CD4 count that was >500 cells/mm3. Bivariate analysis showed that the quality of individualized care was positively correlated with the patients’ CD4 count (r = 0.036; P = 0.657). A negative correlation between the quality of individualized care and the patients’ viral load (r = −0.103; P = 0.177) was also found.

Conclusion:

Provision of individualized care to patients with HIV/AIDS may improve clinical outcomes. In making therapeutic decisions, clinicians should take into cognizance individual patients’ preferences and needs.
Kartograf: An Accurate Geometry-Based Atom Mapper for Hybrid Topology Relative Free Energy Calculations
Authors: Ries Benjamin , Alibay Irfan , Swenson David W H , Baumann Hannah M , Henry Michael M , Eastwood James RB , Gowers Richard J
Published: October 2023

Relative binding free energy (RBFE) calculations have emerged as a powerful tool supporting ligand optimization in drug discovery. Despite many successes, the use of RBFEs can often be limited by automation problems, in particular the setup of such calculations. Atom mapping algorithms are an essential component in setting up automatic large-scale hybrid topology RBFE calculation campaigns. Traditional algorithms typically employ a 2D subgraph isomorphism solver (SIS) in order to estimate the maximum common substructure (MCS). SIS-based approaches can be limited by time-intensive operations and issues with capturing geometry-linked chemical properties, leading potentially to suboptimal solutions. To overcome these limitations, we have developed Kartograf, a geometric-graph-based algorithm that uses primarily the 3D coordinates of atoms to find a mapping between two ligands. In free energy approaches, the ligand conformations are usually derived from docking or other previous modeling approaches giving the coordinates a certain importance. By considering the spatial relationships between atoms related to the molecule coordinates, our algorithm bypasses the computationally complex subgraph matching of SIS-based approaches and reduces the problem to a much simpler bipartite graph matching problem. Moreover, Kartograf effectively circumvents typical mapping issues induced by molecule symmetry and stereoisomerism, making it a more robust approach for atom mapping from a geometric perspective. To validate our method, we have calculated mappings with our novel approach using a diverse set of small molecules and used the mappings in relative hydration and binding free energies calculations. The comparison with two SIS-based algorithms showed that Kartograf offers a fast alternative approach. The code for Kartograf is freely available on Github (https://github.com/OpenFreeEnergy/kartograf). While developed for the OpenFE ecosystem, Kartograf can also be utilized as a standalone Python package.
Nondestructive flash cathode recycling
Authors: Chen Weiyin , Cheng Yi , Chen Jinhang , Bets Ksenia , Salvatierra Rodrigo , Ge Chang , Li John , Luong Duy , Kittrell Carter , McHugh Emily , Gao Guanhui , Deng Bing , Han Yimo , Yakobson Boris , Tour James
Published: October 2023

Effective recycling of end-of-life Li-ion batteries (LIBs) is essential due to continuous accumulation of battery waste and gradual depletion of battery metal resources. The present closed-loop solutions include destructive conversion to metal compounds, by destroying the entire three-dimensional morphology of the cathode through continuous thermal treatment or harsh wet extraction methods, and direct regeneration by lithium replenishment. Here, we report a solvent- and water-free flash Joule heating (FJH) method combined with magnetic separation to restore fresh cathodes from waste cathodes, followed by solid-state relithiation. The entire process is called flash recycling. This FJH method exhibits the merits of milliseconds of duration and high battery metal recovery yields of ~98%. After FJH, the cathodes reveal intact core structures with hierarchical features, implying the feasibility of their reconstituting into new cathodes. Relithiated cathodes are further used in LIBs, and show good electrochemical performance, comparable to new commercial counterparts. Life-cycle-analysis highlights that flash recycling has higher environmental and economic benefits over traditional cathode recycling processes.
Structural hysteresis of dilute fluorine salt aqueous solutions
Authors: Zhang Ning , Wang Shaoheng , Luo Qiongqiong , Tang Jianfeng , Zeng Dewen
Published: October 2023

In contrast with the generally accepted picture for most of the dilute salt aqueous solutions, which defaults that only one structural state/form exists at the given values of system/thermodynamic parameters, in this work, combining characterization of 19F nuclear magnetic resonance, ultraviolet-visible spectroscopies with theoretical calculations, we found that the F−-bearing aqueous solutions with identical component, but prepared by both different pathways, one of which is by mixing subsaturated MF2 solutions and Na//ClO4−(SO42−) solutions (path 1) and another is by mixing concentrated M2+//ClO4−(SO42−) solutions (M = Zn, Cd, Co and Cu) and NaF solution (path 2), can long-termly exist spectrographic distinguishable different thermodynamic steady states, in which the F− in the former preferentially exists in the form of more M2+-F− contact ion pairs (CIP), whereas in the form of more, even all M2+-F− solvent-separated/shared ion pairs (SIP) for the latter. This results from the different solution initial states, where path 1 solutions contain certain amounts of CIPs, whereas there is no CIPs initially in path 2 solutions, the high energy barrier of conversion between SIP and CIP, coupling with the low concentration gradient and thereby small conversion driving force. This makes the solutions exhibit an unusual “apparent” structural hysteresis. Due to the universality of the causes, present findings can expand to other sparingly soluble salts and enhance the significance of solution preparation bias on the thermodynamic studies in solution chemistry domain of sparingly soluble salts.
Discovery of the Polyketide Lagriamide B by Integrated Genome Mining, Isotopic Labeling, and Untargeted Metabolomics
Authors: Fergusson Claire H. , Saulog Julia , Paulo Bruno S. , Wilson Darryl M. , Liu Dennis Y. , Morehouse Nicholas J. , Waterworth Samantha , Barkei John , Gray Christopher A. , Kwan Jason C. , Eustaquio Alessandra S. , Linington Roger
Published: October 2023

Microorganisms from the order Burkholderiales have been the source of a number of important classes of natural products in recent years. For example, study of the beetle-associated symbiont Burkholderia gladioli led to the discovery of the antifungal polyketide lagriamide; an important molecule from the perspectives of both biotechnology and chemical ecology. As part of a wider project to sequence Burkholderiales genomes from our in-house Burkholderiales library we identified a strain containing a biosynthetic gene cluster (BGC) similar to the original lagriamide BGC. Structure prediction failed to identify any candidate masses for the products of this BGC from untargeted metabolomics mass spectrometry data. However, genome mining from publicly available databases identified fragments of this BGC from a culture collection strain of Paraburkholderia. Whole genome sequencing of this strain revealed the presence of a homologue of this BGC with very high sequence identity. Stable isotope feeding of the two strains in parallel using our newly developed IsoAnalyst platform identified the product of this lagriamide-like BGC directly from the crude fermentation extracts, affording a culturable supply of this important class of antifungal agents. Using a combination of bioinformatic, computational and spectroscopic methods we defined the absolute configurations for all 11 chiral centers in this new metabolite, which we named lagriamide B. Biological testing of lagriamide B against a panel of 21 bacterial and fungal pathogens revealed selective antifungal activity against the opportunistic human pathogen Aspergillus niger.
The bioactivities of legumes: a review
Authors: Looi E.P. , MohdMaidin N.
Published: October 2023

Legumes are dehiscent plants which belong to the family of Fabaceae and are rich in
nutrients. Although legumes are known for their beneficial health effects, the consumption
of legumes is still low due to gastrointestinal problems after consumption as well as long
cooking time. Hence, this review aimed to discuss the bioactivities of legumes exerted in
regard to the different extraction methods namely solvent (SE), microwave-assisted
(MAE), ultrasound-assisted (UAE), supercritical fluid (SFE) and pressurized liquid
extraction (PLE). Generally, the MAE legume extract could potentially exert the highest
antioxidant activity than UAE and SE. Meanwhile, UAE legume extract displayed higher
strength in anti-diabetic activity as compared to MAE while SFE legume extract showed
higher anti-diabetic activity than PLE. The effectiveness of antimicrobial and antiinflammatory activity of legumes by different extraction techniques can be predicted by
the amount of total phenolic compound. The higher total phenolic compound of legumes
contributed to the strength of the bioactivity of legumes. The legume extract can also be
applied to additives, nutraceutical products and skin care products. This review aimed to
provide a better understanding of the suitable extraction techniques that potentially exert
the highest bioactivity in legumes and hence increase the consumption of legumes as well
as reduce prejudice towards eating legumes.
Black rice (Oryza sativa L. indica) bran ethanolic extract improved insulin levels
and total antioxidant capacity in type 2 diabetic rats
Authors: Eviana R. , Widyastiti N.S. , Mahati E. , Syauqy A. , Al-Barri A.N.
Published: October 2023

Type 2 Diabetes Mellitus (T2DM) showed a decrease in insulin levels and Total
Antioxidant Capacity (TAC). Black rice (Oryza sativa L. indica) bran contained a
phytochemical constituent that could ameliorate insulin levels and TAC in T2DM. This
study aimed to determine the effect of black rice bran ethanolic extract on insulin levels
and TAC in T2DM rats. The black rice bran ethanolic extract was prepared using the
maceration method. It was a true experimental study with pre-post-test randomized control
group design using forty-two male Wistar rats which were divided into six groups: healthy
control, T2DM control (C-), T2DM + Metformin (C+) and T2DM + black rice bran
ethanolic extract at the doses of 15 mg/200 g BW (T1), 30 mg/200 g BW (T2) and 60
mg/200 g BW (T3). The treatment was given oral gavage for 21 days. The results showed
that there was a significant increase in insulin levels and TAC in treatment groups
compared with the T2DM control (p<0.05). The improvement in TAC from the treatment
of black rice bran ethanolic extract was the same as metformin. It could be concluded that
black rice bran ethanolic extract increased insulin levels and TAC in T2DM rats with the
most effective dose of 60 mg/200 g BW. The result indicated that black rice bran ethanolic
extract at a dose of 60 mg/200 g BW was as effective as metformin in increasing TAC.
Prevalence, molecular detection and antimicrobial susceptibility of Listeria
monocytogenes isolated from milk, poultry meat and meat products
Authors: Faruk M.O. , Ema F.A. , Islam M.A. , Khatun M.M.
Published: October 2023

Listeria monocytogenes is a food borne zoonotic pathogen that causes listeriosis in people
and animals. It has a low incidence but a high case fatality rate. The goal of this study was
to assess the prevalence of L. monocytogenes in raw and frozen milk, raw and frozen
poultry meat and meat products as well as their molecular identification and antimicrobial
susceptibility. A total of 100 samples were collected from four different locations in
Mymensingh town, including raw milk (n = 20), frozen milk (n = 20), raw poultry meat (n
= 20), frozen poultry meat (n = 20), frozen chicken meat ball (n = 10), and chicken burger
(n = 10). Listeria selective PALCAM agar was used to isolate L. monocytogenes from the
samples. Listeria spp. created a black zone around the colonies on this agar. Gram
staining, motility testing, Christie, Atkins, Munch-Petersen (CAMP) testing, haemolysis
testing, sugar fermentation testing and other biochemical assays were used to confirm the
presence of L. monocytogenes. The disc diffusion method was used to test antibiotic
sensitivity against ten antibiotics: ampicillin, vancomycin, gentamycin, streptomycin,
cefixime, cefalexin, norfloxacin, colistin, erythromycin, and amikacin. The prevalence of
L. monocytogenes in various samples was found to be 30% in raw milk, 0% in frozen
milk, 40% in raw poultry meat, 10% in frozen poultry meat and not found in meat
products. Market 1 had a prevalence of 13.33%, market 2 had a prevalence of 15%,
market 3 had a prevalence of 0%, and market 4 had a prevalence of 0%. The isolates of L.
monocytogenes were shown to be susceptible to amikacin, gentamycin, vancomycin,
streptomycin and norfloxacin but resistant to ampicillin, cefixime, cefalexin, colistin and
erythromycin. According to the findings of this study, multidrug-resistant L.
monocytogenes can be found in milk, poultry meat, and meat products, posing a public
health risk.
Correlation between Diagnostic Magnetic Resonance Imaging Criteria and Cerebrospinal Fluid Pressure in Pediatric Idiopathic Intracranial Hypertension
Authors: Beizaei Behnam , Toosi Farrokh Seilanian , Shahmoradi Yousef , Akhondian Javad , Ashrafzadeh Farah , Toosi Mehran Beiraghi , Imannezhad Shima , Kooshki Alireza , Nejad Ehsan Hassan , Payandeh Asma , Tavakkolizadeh Nahid , Ghalibaf AmirAli Moodi , Hashemi Narges
Published: October 2023

Purpose: Idiopathic intracranial hypertension (IIH) is a clinical syndrome that mimics brain tumors with increased intracranial pressure. The present study is designed to investigate the diagnostic criteria of magnetic resonance imaging (MRI) and the severity of cerebrospinal fluid (CSF) pressure to understand the relationship and frequency of these criteria with the level of CSF pressure.Methods: The present cross-sectional study was conducted on children diagnosed with IIH between the years 2011 and 2020, who were admitted to the pediatric neurology department of Ghaem Hospital, Mashhad, Iran. Clinical manifestations and imaging findings of the patients were recorded through a checklist. Results: Forty-nine patients were included in the study; 27 (55.1%) were male, and 22 (44.9%) were female. The average CSF pressure was 40.64±20.63 cmH2O. The mean diameter distension of the perioptic subarachnoid space was 6.02±1.21 mm. Six (10.8%) patients had unilateral transverse sinus stenosis with an average CSF pressure of 20.47±36.80 cmH2O and 11 (21.4%) patients had bilateral transverse sinus stenosis with an average pressure of 48.22±21.04 cmH2O. In 22 (44.89%) patients, flattening of the posterior globe with the CSF pressure of 48.80±17.94 cmH2O was reported. Twenty-four (49%) patients had optic nerve tortuosity, with an average CSF pressure of 46.52±20.33 cmH2O. Among the diagnostic criteria, the pressure had a significant relationship with the flattening of the posterior globe (P<0.022).Conclusion: Since MRI is a non-invasive method for examining IIH, the findings of this study may aid in diagnosing and monitoring these patients.
Review and Bibliometric Analysis of Biogas Power Plants in Indonesia
Authors: Setyanansyach Dhasa Ikrar , Setiyo Muji , Raja Thirunavukkarasu
Published: October 2023

The demand for energy is increasing due to population growth, technological advancements, and a growing need for sustainable energy sources. Indonesia, which faces an energy deficit, is exploring alternatives to fossil fuels. Biogas, produced through the anaerobic fermentation of organic matter, offers a clean and sustainable energy option while addressing waste disposal issues. Therefore, this literature review examines various aspects of a biogas power plant, including a feasibility study that encompasses technical and economic analyses, generator design, trials, implementation, and post-implementation evaluation. In this review, we gathered scientific papers from Google Scholar using the keywords "pembangkit listrik biogas" between 2019 and 2022, with a focus on recent content. Patents and citations were excluded from the Google Scholar searches to ensure article relevance. Out of a total of 40 articles, 30 were rejected because they did not originate from scientific journals. The collected articles are categorized based on the materials used for biogas generation in power plants. This systematic approach yielded 10 relevant articles. Consequently, the literature reveals that various raw materials, such as palm oil mill waste (POME), livestock manure, and organic waste, hold the potential for biogas production. The results emphasize the economic feasibility of specific biogas projects, the environmental challenges they pose, and the positive impact they have on community well-being
DESAIN E-LKPD BERBASIS STEM TEMA KEARIFAN LOKAL BERNUANSA PENDIDIKAN KARAKTER MATERI LINGKARAN
Authors: Prihaswati Martyana , Yuliani Istiqomah , Purnomo Eko Andy , Adnan Mazlini , Khasanah Uswatun
Published: October 2023

Penggunaan media pembelajaran belum dioptimalkan di MTS Muhammadiyah 03 Ngargosari terutama pada pembelajaran matematika. Pembelajaran matematika terbatas menggunakan buku LKS cetak, oleh karena itu dibutuhkan sebuah desain media pembelajaran yang dapat digunakan untuk kegiatan belajar di kelas maupun pembelajaran mandiri. Penelitian ini bertujuan untuk mendesain E-LKPD yang valid berbasis STEM tema kearifan lokal bernuansa pendidikan karakter materi lingkaran kelas VIII. Jenis penelitian ini merupakan penelitian RnD (Research and Development). Model pengembangan yang digunakan adalah model 4D (Define, Design, Development, Dissiminate) namun dibatasi pada tahap perancangan. Instrumen dalam penelitian menggunakan observasi, wawancara, dan lembar validasi ahli kemudian diintepretasikan menjadi data deskriptif. Hasil penelitian berupa desain E-LKPD dan hasil kevalidan E-LKPD dari ahli media dan ahli materi. Berdasarkan ahli media, E-LKPD mendapatkan rerata penilaian 89% dengan kategori sangat valid, sedangkan berdasarkan ahli materi, E-LKPD mendapatkan rerata penilaian 85% dengan kategori sangat valid. Rerata total E-LKPD dari ahli media dan ahli materi mencapai 87% dengan kategori sangat valid, hal ini menunjukkan bahwa E-LKPD layak pada penilaian validitas.
PENGARUH KEPERCAYAAN DIRI TERHADAP KEMAMPUAN PEMECAHAN MASALAH MATEMATIS SISWA SMP N 7 SALATIGA
Authors: Dewi Arsiana Kusuma , Zaenuri Zaenuri , Walid Walid , Sugiman Sugiman , Pujiastuti Emi
Published: October 2023

Tujuan dari penelitian ini adalah untuk mengukur tingkat kepercayaan diri siswa, tingkat kemampuan pemecahan masalah matematis, dan apakah kepercayaan diri berpengaruh terhadap kemampuan pemecahan masalah matematis siswa di SMPN 7 Salatiga pada kelas VIII. Penelitian ini menggunakan metode kuantitatif. Siswa SMPN 7 Salatiga yang berada di kelas VIII adalah populasi penelitian ini. Metode simple random sampling digunakan untuk memilih 69 siswa sebagai sampel penelitian. Digunakan angket, soal berbentuk esai, dan dokumentasi untuk memperoleh data. Analisis regresi linier sederhana digunakan untuk menganalisis data dengan taraf signifikansi 5%. Berdasarkan hasil olah data diperoleh rata-rata kepercayaan diri sebesar 52,17% dengan kategori sedang. Rata-rata untuk kemampuan pemecahan masalah matematis siswa juga tergolong kategori sedang sebesar 50,73%. Didapat nilai signifikansi yaitu 0,00 < 0,05 pada uji regresi linier sederhana. Kesimpulannya adalah bahwa kepercayaan diri mempengaruhi kemampuan siswa untuk memecahkan masalah matematika. Diperoleh kepercayaan diri mempunyai pengaruh sebesar 76,2% terhadap kemampuan siswa dalam memecahkan masalah matematis, sedangkan 23,8% dipengaruhi oleh aspek lain.
ANALISIS KESALAHAN PESERTA DIDIK DALAM MENGERJAKAN SOAL SPLDV BERDASARKAN KEMAMPUAN BERPIKIR KRITIS
Authors: Septiana Reni , Sutiarso Sugeng
Published: October 2023

Kemampuan berpikir kritis merupakan salah satu kemampuan yang sangat penting dimiliki dalam kehidupan sehari-hari, kenyataan yang terjadi dalam kegiatan belajar mengajar berlangsung ditemukan bahwa kemampuan berpikir kritis peserta didik lemah karena mereka belum memiliki kemampuan tersebut. Solusi yang ditawarkan dari permasalahan ini adalah pemahaman mengenai kemampuan berpikir kritis yang harus dimiliki oleh peserta didik dalam materi yang sedang dipelajari, khususnya dalam materi persamaan linier Dua Variabel. Penelitian dilaksanakan di SMP Assahil lampung Timur pada Tahun Pelajaran 2022/2023 semester genap. Teknik pengumpulan data menggunakan soal uraian dan wawancara. Teknik analisis data menggunakan deskriptif serta penarikan kesimpulan. Hasil penelitian berdasarkan yang telah didapatkan oleh peneliti yaitu dari segi aspek penerapan yang telah dilakukan oleh peserta didik dalam kesalahan mengerjakan soal persamaan linier Dua Variabel.
ANALISIS KEMAMPUAN PEMAHAMAN KONSEP MATEMATIS PADA MATERI STATISTIKA BERDASARKAN TEORI APOS DITINJAU DARI GAYA KOGNITIF REFLEKTIF DAN IMPULSIF
Authors: Wicaksono Febri Eko , Utami Rizky Esti , Purwati Heni
Published: October 2023

Tujuan penelitian ini adalah Untuk mengetahui kemampuan pemahaman konsep matematis pada materi statistika berdasarkan teori APOS ditinjau gaya kognitif reflektif dan impulsif. Penelitian ini merupakan penelitian kualitatif. Subjek penelitian terdiri dari 4 siswa dari 36 siswa kelas XI MIPA 7 SMA Negeri 1 Jakenan, yang terdiri dari 2 siswa dengan gaya kognitif reflektif dan 2 siswa dengan gaya kognitif impulsif. Gaya kognitif subjek ditentukan berdasarkan dari nilai Matching Familiar Figure Test (MFFT) dan kemampuan pemahaman konsep siswa diperoleh dari Tes Kemampuan Pemahaman Konsep Matematis Siswa dan wawancara. Kesimpulan dari penelitian ini adalah subjek reflektif mampu mencapai pemahaman konsep berdasarkan teori APOS pada tahap aksi, proses, objek, dan skema. Sedangkan subjek impulsif mampu mencapai pemahaman konsep berdasarkan teori APOS pada tahap aksi, proses, dan objek. Dalam menggunakan instrumen MFFT, data yang dicatat meliputi banyaknya waktu (t) yang digunakan siswa untuk menjawab keseluruhan soal yang diberikan dan frekuensi (f) kesalahan jawaban yang diberikan.
PENGARUH MODEL PEMBELAJARAN CONNECTED MATHEMATICS PROJECT TERHADAP KEMAMPUAN KONEKSI MATEMATIS BERBANTUAN DESMOS PADA SISWA SMA KELAS X
Authors: Damayanti Dwy , Purwaningrum Jayanti Putri , Ulya Himmatul
Published: October 2023

Tujuan penelitian ini yaitu menganalisis pencapaian kemampuan koneksi matematis siswa yang belajar melalui model pembelajaran Connected Mathematics Project dengan berbantuan Desmos lebih baik dibandingkan siswa yang belajar melalui model pembelajaran direct instruction. Penelitian dilaksanakan di kelas XE7 dengan jumlah siswa 36 siswa dan XE5 dengan jumlah 35 siswa. Jenis penelitian ini adalah kuantitatif dengan metode Quasi Eksperimental Design. Adapun, desain yang digunakan dalam penelitian ini adalah Nonequivalent Pretest-Posttest Control Group Design yang berfungsi mengetahui pengaruh model pembelajaran Connected Mathematics Project terhadap kemampuan koneksi matematis siswa. Rancangan penelitian ini adalah pre-experimental design dengan one-group pretest-posttest design. Analisis data yang adalah uji normalitas, uji homogenitas, dan analisis data meliputi uji t dua sampel independent. Dari hasil penelitian, diperoleh nilai p-value yaitu 0,003 ≤ 0,025. Artinya rata-rata kemampuan koneksi matematis siswa yang belajar melalui model pembelajaran Connected Mathematics Project dengan berbantuan Desmos lebih baik dibandingkan siswa yang belajar melalui model pembelajaran direct instruction
Komunikasi Visual Kampanye Kesadaran Anak Dewasa Awal Mendukung Ibu pada Fase Sarang Kosong
Authors: Elserisa Lily
Published: October 2023

Abstract The empty nest phase is experienced by the mother in middle adulthood (40-60 years) when the children leave the house and start a new life. This phase creates feelings of discomfort for the mother and has psychological implications. If there’s no proper coping mechanism it can interfere physical health of the mother as well. Social support from children in the form of intensive communication is needed in undergoing this phase. This study aims to design a visual communication awareness campaign for early adulthood supporting mothers in empty nests. This design was carried out using the Design Thinking method (Brown, 2008) which was combined with a message delivery strategy and media selection (Kasilo, 2008) with three major stages: inspiration, ideation, and implementation. The result of the design is visual communication for the awareness campaign entitled “Keluar Sarang” through the media: Instagram Story content, comics in Instagram Multiple Posts, ambient media plates, posters, clothes hangers, mugs, sticker packs, and pillows that are persuasive, communicative, and synergistic. Keywords: Awareness Campaign, Empty Nest Syndrome, Illustration, Visual Communication.
Multi-factor Modeling as an Enabler of Supply Chain Risk Management
Authors: G Cook William
Published: October 2023

Supply chains of large-scale, technologically complex products rely on a vast network of suppliers. While supply chain efficiency has improved with the expansion of globalization, supply chain resiliency appears to have worsened. Some would argue, in light of the effects of a global pandemic and war in Eastern Europe, that supply chains are increasingly fragile. Since 2000 academic research has expanded to address Supply Chain Risk and its focus on resiliency, going beyond Supply Chain Management which focuses instead more on efficiency. In this paper the author explores the application of multi-factor models in identifying and assessing risk factors that impact supply chain resiliency. This study describes efforts underway by the author to develop a data analytics tool to illuminate and assess the risks in supply chains for large scale weapon systems procured by the US Department of Defense.
On the Diophantine Equation (p+n)^x+p^y=z^2 where p and p+n are Prime Numbers
Authors: Orosram Wachirarak
Published: October 2023

In this paper, we study the Diophantine equation (p+n)^x+p^y=z^2, where  p, p+n are prime numbers and  n  is a positive integer such that n equiv mod 4.  In case p=3 and n=4, Rao{7} showed that the non-negative integer solutions are (x,y,z)=(0,1,2) and (1,2,4) In case p>3 and pequiv 3pmod4, if n-1 is a prime number and 2n-1 is not prime number, then the non-negative integer solution (x, y, z) is (0, 1,\sqrt {p+1}) or ( 1, 0, \sqrt{p+n+1}). In case pequiv 1pmod4, the non-negative integer solution (x,y,z) is also (0, 1,\sqrt {p+1}) or ( 1,0, \sqrt{p+n+1}).
On the Number of Restricted One-to-One and Onto Functons Having Integral Coordinates
Authors: Latayada Mary Joy R.
Published: October 2023

Let $N_m$ be the set of positive integers $1, 2,  \cdots, m$ and $S \subseteq N_m$. In 2000, J. Caumeran and R. Corcino made a thorough investigation on counting restricted functions $f_{|S}$ under each of the following conditions:\begin{itemize}\item[(\textit{a})]$f(a) \leq a$, $\forall a \in S$;\item[(\textit{b})] $f(a) \leq g(a)$, $\forall a \in S$ where $g$ is any nonnegative real-valued continuous functions;\item[(\textit{c})] $g_1(a) \leq f(a) \leq g_2(a)$, $\forall a \in S$, where $g_1$ and $g_2$ are any nonnegative real-valued continuous functions.\end{itemize}Several formulae and identities were also obtained by Caumeran using basic concepts in combinatorics.In this paper, we count those restricted functions under condition $f(a) \leq a$, $\forall a \in S$, which is one-to-one and onto, and establish some formulas and identities parallel to those obtained by J. Caumeran and R. Corcino.
New Variants of Newton's Method for Solving Nonlinear Equations
Authors: Sapkota Buddhi Prasad , Jnawali Jivandhar
Published: October 2023

Two Newton-type iterative techniques have been created in this work to locate the true root of univariate nonlinear equations. One of these can be acquired by modifying the double Newton's method in a straightforward manner, while the other can be gotten by modifying the midpoint Newton's method. The iterative approach developed by McDougall and Wortherspoon is employed for the change. The study demonstrates that the modified double Newton's approach outperforms the current one in terms of both convergence order and efficiency index, even though both methods assess the same amount of functions and derivatives every iteration. In comparison to the midpoint Newton's technique, which has a convergence order of 3, the modified midpoint Newton's method has a convergence order of 5.25 and requires two extra functions to be evaluated per iteration. In order to evaluate the effectiveness of recently introduced approaches with current methods, some numerical examples are shown in the final section.
Generalized Different Types of Mappings in Fuzzy Bitopological Spaces
Authors: Ahmed Alharbi Ahlam , Kilicman Adem
Published: October 2023

The principle objective of this research is to present generalised functions ideas which are: fuzzy generalised continuous, generalized strongly continuous, generalized irresolute, generalized open and closed mapping, and the last part is the homomorphism in fuzzy bitopological spaces. We also study the relationships between them, their characteristics, their composition, and some important theories and counterexamples.
PROBLEMATIC ISSUES OF JUDICIAL AUTHORIZATION OF PUBLIC INSPECTION OF RESIDENTIAL PREMISES
Authors: KAUNOV ALEKSANDR
Published: October 2023

The article analyzes the problematic issues arising in connection with the receipt by the operational units of the internal affairs bodies of the Russian Federation of a court decision to conduct a public inspection of residential premises. The necessity of minimizing the use of coercion in the course of conducting a public inspection of residential premises, within the framework of the received judge's decision, is substantiated. In the article, the author focuses on the need for legislative consolidation of subsequent judicial control over the conduct of the operational search event in question in order to ensure the legality of its results. The author proposes amendments to the operational search legislation, in terms of legal regulation of judicial authorization of public inspection of residential premises.
LEGAL REGULATION OF CONSERVATION AND STRENGTHENING TRADITIONAL RUSSIAN SPIRITUAL AND MORAL VALUES WITHIN STRATEGIC PLANNING
Authors: KASHKINA EKATERINA
Published: October 2023

The article defines the main guidelines of the Russian Federation in the construction of statehood. Statistical data of various time periods are presented, indicating the commitment of Russian citizens to a particular system of values. The analysis of the main implemented Strategies for the development of the state in the format of orientation to traditional spiritual and moral values, namely: National security Strategies, Strategies of the state national Policy of the Russian Federation for the period up to 2025, Strategies for countering extremism in the Russian Federation up to 2025, Strategies for the development of the Information Society in the Russian Federation for 2017 - 2030, Strategies the State Anti-Drug Policy of the Russian Federation for the period up to 2030, the Strategy of Comprehensive Child Safety in the Russian Federation for the period up to 2030, Strategies for the development of education in the Russian Federation for the period up to 2025. The assessment of the importance of traditional Russian spiritual and moral values for the further development and strength-ening of statehood in the Russian Federation is given.
DIGITAL TRANSFORMATION OF DRUG CRIME AS AN OBJECT OF FORENSIC RESEARCH
Authors: Zemtsova S
Published: October 2023

The article focuses on the need to develop generic (basic, enlarged, integrative) methods of investigation of drug crimes, reflecting on the one hand the transformed "pre-digital" ways of committing crimes, and on the other the specifics of the investigation. The prerequisites for this are: the changed structure of the drug market; reorientation from the smuggling of synthetic drugs to their production within the country, as well as the use of "drug constructors"; involvement in the turnover of "designer" precursors; the use of digital currency for the purpose of conspiracy of criminal acts and legalization of drug proceeds.
COMPETITIVE STRATEGY ANALYSIS OF TOURISM (CASE STUDY IN THE MARINE TOURISM SECTOR IN NORTH MINAHASA REGENCY)
Authors: Pondaag Jessy Jousina , Soepeno Djurwaty , Lumintang Genita Gracia
Published: October 2023

This type of research is a quantitative research. The research location was carried out at the Paal Beach tourism object, which is located in Marinsow Village, East Likupang District, North Minahasa Regency. The sampling technique used purposive sampling method.Researchers took a sample of 100 respondents. Data collection methods through observation, questionnaires, and documentation. Data analysis techniques using scoring techniques, as well as SWOT analysis.The results showed that the supporting factors for the development of Paal Beach tourism objects were the attractiveness of Paal Beach tourism objects with the beautiful white sand and sea, as well as good road accessibility. Factors inhibiting development are old and lacking infrastructure such as public toilets and lodging, the absence of public transportation, and the lack of supporting facilities such as hotel communications and restaurants around tourist attractions. The tourism development strategy based on the SWOT analysis is in quadrant I, the strategy recommendations given are Progressive. The right strategy to be carried out at the Paal Beach tourism object is to maintain the beauty of the beach, increase the number of places selling souvenirs typical of the region, buildbasic infrastructure facilities at tourist sites and make maximum use of existing human resources and intensify promotions and build adequate and easy accessibility visitors.
Letter from the editors
Authors: Bray Nancy , Chilewska Anna , Kumar Rigvi , Parker Anita
Published: October 2023

Welcome to the third issue of Writing across the University of Alberta, a journal for undergraduate writing in Writing Studies at the University of Alberta. The third issue of WAUA features written works by Kevin Bouvier, Junhui Li, Feisal Sharif, Reham Albakouni, Zhuoxin Wang, Sabrina Rivelazione, Evan Martens, and Ishrath Khan.
Proposing a Smart Performance Management System for Production Workshop Based on Virtual Organizational Deoxyribonucleic Acid Concept
Authors: Ubaid Alaa , Dweiri Fikri
Published: October 2023

This research aims to develop and validate a smart PMS. The PMS will create a foundation for PMSs that will be used by organizations in the digital era. A three-step methodology was used in the current research. First, the archival literature analysis was used to identify the features and elements of the robust PMSs. Second, a generic PMS was constructed based on the results of the first step. Third, the generic PMS was amended, implemented in the workshop, and validated by discussing the results with a focus group of experts. The academic and technical contribution can be seen in proposing a generic Virtual Organizational Deoxyribonucleic Acid (V-DNA) concept and smart PMS (Performance Management Dashboard (PMD) and Decision-Making Tool (DMT)) based on the features and elements of the robust PMSs. The generic V-DNA and PMS were amended and implemented in the stated workshop. Then, the validation process was done by presenting the implementation results to a focus group of academic experts and taking their feedback.  Applying the PMD and the DMT to monitor, analyze, and manage workshop performance was successful. The PMD proved a useful tool that can provide a holistic view of the workshop performance areas instead of focusing on isolated business aspects such as workshop productivity or efficiency. The decision-makers directly identified the low-performing and highly performing KPIs/processes/sub-processes and identified the root causes of low and high performance. The DMT proved a useful tool. The decision-makers could evaluate all sub-processes and rank them based on the values and weights of the decision-making criteria, highlighting the areas that need improvement. The originality and novelty of the proposed PMS and the V-DNA were proved through a systematic literature review process. The implications of the research can be seen in the possibility of testing the generic V-DNA and the PMS templates in organizations of different sizes and sectors to check their applicability. Moreover, other layers of the organizational V-DNA can be proposed. The current research assists the practitioners and managers in constructing the PMSs they need for their workshops/factories/companies.
Influence of the spectral composition of light on the morphogenesis of seedlings of Myrtus communis L. and Psidium cattleianum Sabine (Myrtaceae Juss.) in a small pot greenhouse culture
Authors: Hetko N. V. , Kabusheva I. N. , Sak N. L. , Titok V. V.
Published: October 2023

The influence of the intensity and spectral composition of LED and fluorescent (FL) light on the morphogenesis of Myrtus communis L. and Psidium cattleianum Sabine (Myrtaceae) seedlings in a small pot greenhouse culture in the Central Botanical Garden of the National Academy of Sciences of Belarus (CBG) was studied. It was shown that in terms of plant height, the number and total surface of leaves, as well as the specific dry weight of the leaf, seedlings of both species over 120 cultivation days in all variants with irradiation surpassed control plants. The increase in dry weight per 1 cm2 of leaf (mg with respect to the control) that characterizes the photosynthesis productivity was influenced by the spectral composition of radiation, which made it possible to identify interspecies and intervariant differences. The variant with an FL Narva lamp with a total photon flux density PFD = 76.22 µmol/m2/s, with a share of the green spectrum PFD-G = 46.47 %, red – PFD-R = 20.00 % and with the value of the ratio R/FR = 5.77 in the subtropical long-day species M. communis, it was 1.24 mg, while in the tropical short-day species P. cattleianum had only 0.39 mg. In plants irradiated with an LED lamp with a photon flux density PFD = 186.20 µmol/m2/s, with a share of PFD-R = 59.34 %, and at R/FR = 54.43, the growth was 2.60 and 1.93 mg with respect to control, respectively. LED sources are the most efficient in terms of the photosynthesis productivity for both short-day and long day plants.
On the Bernoulli–Euler–Lagrange–Aitken numerical method for roots of polynomials
Authors: Lebedev A. V. , Trubnikov Yu. V. , Chernyavsky M. M.
Published: October 2023

The article presents a development of the Euler–Lagrange method for calculation of all roots of an arbitrary polynomial P(z) with complex coefficients based on the calculation of the limits of ratios of determinants (as in the Bernoulli–Aitken–Nikiporets methods) built by means of the Taylor and Laurent series coefficients for the function P′(z) / P(z).
Quantum-chemical study of the stability of solvents with respect to strong organic bases
Authors: Kulsha A. V. , Ivashkevich O. A.
Published: October 2023

The possibility of theoretical calculation of the ionization constants of strong organic bases in dimethyl sulfoxide and hexametapole was studied by the DLPNO-CCSD (T) and DFT methods. By comparison with the experimental data available in the literature, it has been established that the error of such calculations lies within 1–2 pKa units. The stability of some ionizing solvents against strong organic bases is investigated, the mechanisms of decomposition of solvent molecules in strongly basic media are predicted, and the corresponding energy barriers are estimated. According to the calculations, among ionizing solvents, hexamethylphosphoramide has the highest resistance to superbases, being able to maintain pH > 50 at room temperature. At the same time, 1,3-dimethyl-2-imidazolidinone gradually decomposes under these conditions, while tetrahydrofuran and pivalonitrile are even less stable.
Study and conservation of biodiversity of honey bees in Russia
Authors: Borodachev A. V. , Savushkina L. N.
Published: October 2023

Middle Russian, Bashkir, Carpathian, Gray Mountain Caucasian and Far Eastern bees are bred in Russia. As a result of selection based on selected material, the following breed types were reared: “Priokskiy”, “Orlovskiy”, “Tatarskiy” and “Burzyanskaya Bortevaya” of Middle Russian; “Maykopskiy” and “Moskovskiy” of Сarpathian; and “Krasnopolyanskiy” of Gray Mountain Caucasian breeds. Work was carried out at farms-originators of breed types “Priokskiy” on the apiaries of Federal beekeeping research centre, “Tatarskiy” – selective centre “Tatarskiy”, “Burzyanskaya Bortevaya” – State nature reserve “Shulgan-Tash”, “Krasnopolyanskiy” – Krasnopolyanskya Experimental station of Beekeeping. The materials of approbation of breeding achievements of the Bashkir and Far Eastern breeds and breed types “Orlovskiy”, “Maikopskiy” and “Moskovskiy” were analyzed. The research was guided by the “Method of conducting tests for distinctness, uniformity and stability”. Honey bee (Apis mellifera L.)” and “Methods of research work in beekeeping”. The characteristics of the morphometric features of bees, queens and drones, as well as the ethological features of bee colonies of reared breeds and breed types are presented. Reserves, sanctuaries and breeding farms are indicated that are engaged in the conservation, selection improvement and reproduction of selected queen bees and families of a certain origin, as well as their sale in breeding zones for further reproduction. To conduct breeding work in beekeeping, a number of documents have been prepared: Regulations on the state nature reserve for the conservation of the gene pool of the native breed (population) of the honey bee, the Rules for classifying farms engaged in breeding bees as breeding farms, the National standard for the queen bee, the Interstate standard for the bee colony. The study of the gene pool of breeds, types and populations of bees, the control of their purity are the main conditions for its conservation and rational use.
Insects as an alternative protein source in poultry nutrition: review
Authors: Edea Chala , Verkhoturov V. V.
Published: October 2023

In today’s world, poultry farming is the most dynamically developing branch of agro-industrial complex, providing the population of the planet with products of animal origin. However, poultry meat producers in developing countries face the challenges of high cost and low-quality poultry feed. Limited use of available protein sources forces professionals to consider using alternative protein sources such as forage insects. Due to high content of fat (30–40 %) and protein components (40–60 %) and wide distribution, insects are a cost-effective and potentially sustainable feed resource for poultry feeding. The conducted studies confirm that insect meal (larvae of black soldier fly, housefly, large mealworm, silkworm, grasshopper and locust) can be considered as a potential replacement for fishmeal and soybean meal in poultry feed mixtures. A review of scientific literature is presented, which highlights the use of insects as a source of protein and biologically active substances (polyunsaturated fatty acids and antimicrobial peptides) for poultry feeding and possibility of large-scale insect cliching for feed production. Information is provided on the chemical composition, nutritional and biological value of insect-based feed meal in comparison with soybean and fishmeal. There is practically no information in the literature about the negative consequences for chicken growth when using insect meal in feeding. Most scientific publications indicate that physiological indicators and productivity, when insect meal was used in poultry feeding, were practically not inferior to those in birds fed with soy or fishmeal. Thus, the use of insects as a feed component in poultry farming is a promising aspect for sustainable development of animal husbandry, which allows solving the problems of waste processing and rational use of feed resources.
Results of production tests and economic evaluation of a rotary beater-combing device on a flax harvester
Authors: Sharshunov V. A. , Bosak V. N. , Cajc M. V. , Kocuba V. I. , Khromenkova T. L. , Levchuk V. A.
Published: October 2023

The results of production tests of a rotary beater-combing device developed at the EE BSAA for separating seeds from flax stalks in the implementation of combine harvesting technology are presented in the paper. As a result of the research, regularities were determined for changes in the purity of threshing, the degree of damage to seeds and stems depending on the thickness of the strip of flax stems threshed by the developed device installed in the “Dvina-4M” flax harvester. Regularities of changes in the purity of threshing and the degree of damage to flax stalks from the gap between the rotor and deck in the phase of yellow and brown ripeness of flax at different rotor speeds have been determined. The results of comparative tests of a flax harvester equipped with a rotary beater-combing device in comparison with a flax harvester equipped with a single-drum combing device are presented. Use of a rotary beater-combing device on a flax harvester allows to increase the performance of the combine by 8.7 %, reduce the total loss of seeds by 32.35 % and 4.2–7.32 % as a result of undercombing, reduce damage to flax stalks affecting the output of long flax fiber by 38.01 %. Also, a decrease in the volume of the resulting flax heap was noted when using a rotary beater-combing device, depending on the quality of the stem and the phase of flax ripeness, by 28.5–56.3 % in comparison with the comb apparatus. The annual economic effect of the rotary beatercombing device will make 7831 rubles, the economic effect per 1 ha – 156.6 rubles in prices of the I quarter of 2023.