bluuebunny/crossref_metadata_2025 huggingface dataset:
Interactions between Bacillus cereus CGMCC 1.895 and Clostridium beijerinckii NCIMB 8052 in coculture for butanol production under nonanaerobic conditions
Authors: Mai Shuai , Wang Genyu , Wu Pengfei , Gu Chunkai , Liu Hongjuan , Zhang Jianan , Wang Gehua
Published: June 2016

Low oxygen tolerance and substrate restriction continues to hamper the process of biobutanol industrialization. In this work, butanol fermentation with cocultures of Bacillus cereus China General Microbiological Culture Collection Center (CGMCC) 1.895 and Clostridium beijerinckii NCIMB 8052 under nonanaerobic conditions was investigated, and the interactions between these two strains were examined. The addition of B. cereus CGMCC 1.895 resulted in higher oxygen tolerance and a wider range of substrate utilization, compared with the pure culture of C. beijerinckii NCIMB 8052. Butanol concentration reached 10.49 g/L with an optimized inoculation size of 90% under nonanaerobic conditions, and this concentration was close to that of pure C. beijerinckii NCIMB 8052 culture under anaerobic conditions. Dynamic relative abundance analysis demonstrated that the ratio of C. beijerinckii NCIMB 8052 accounted for nearly 99% of the cocultured cells. Furthermore, the substrate utilization range was expanded, allowing the use of corn mash for butanol production. The final concentration of butanol and total solvents was 6.78 and 10.52 g/L, respectively. Coculture also was performed successfully in a 5‐L fermenter and 8.75 g/L butanol was obtained. Dynamic dissolved oxygen analysis demonstrated that B. cereus consumed the dissolved oxygen in the broth and resulted in the anaerobic condition for C. beijerinckii.
Avoiding collateral damage in the war on hypertension
Authors: Bates Mark C.
Published: June 2016

Key Points

When performed by experienced clinicians, renal nerve denervation (RND) can be done with very low risk of complication and/or acute renal injury

Renal function seems to remain unchanged in this small series over 3 years

More studies are needed to establish the role of renal biomarkers in assessment of acute renal injury in this setting and larger series of RND in azotemic patients should be done before the procedure indications can be expanded
Percutaneous closure of residual leaks after device occlusion of the left atrial appendage
Authors: Feldman Ted
Published: June 2016

Key Points

Large leaks (≥ 3mm) after percutaneous left atrial appendage (LAA) device occlusion may occur in about 2% of cases.

There is no clear relationship between incomplete occlusion of the LAA and risk of thromboembolism.

Leak closure with percutaneous devices is feasible and safe.

A small percentage incidence of leaks after device closure in the large LAA device closure population represents a significant number of patients.
Between a rock and a hard place: TAVR and ESRD
Authors: Gilchrist Ian C. , Hansen James
Published: June 2016

Key Points

Aortic stenosis in combination with end‐stage renal disease (ESRD) is a high‐risk combination for surgical valve replacement and little data exists on the role of transcatheter aortic valve replacement (TAVR)

Pooled retrospective data from eight experienced TAVR sites suggests that TAVR can be accomplished in ESRD patients with first generation percutaneous valve at a risk similar to surgical approaches.

Even with TAVR, valve replacement in the ESRD patient remain high risk and future improvements in technology and approaches to this poorly studied group are needed.
Innovative Internally Circulating Reactor Concept for Chemical Looping‐Based CO2 Capture Processes: Hydrodynamic Investigation
Authors: Zaabout Abdelghafour , Cloete Schalk , Amini Shahriar
Published: June 2016

An experimental hydrodynamic investigation has been carried out for a novel internally circulating chemical looping (ICCL) reactor concept proposed to reduce the technical complexities encountered in conventional chemical looping combustion (CLC) and reforming (CLR) technologies. The concept consists of a single reactor with internal physical separations dividing it into two sections, i.e., the fuel and air sections. The trade‐off for this reduction in process complexity is increased gas leakage between the two reactor sections, so a pseudo‐2D cold‐flow experimental unit was designed. The ICCL concept remains highly efficient in terms of CO2 separation while ensuring significant process simplifications. The solids circulation rate also proved easy to control by adjusting the fluidization velocity ratio and the bed loading. In the light of the excellent hydrodynamic performance, the ICCL concept appears to be well‐suited for further development as a CLC/CLR reactor model.
12/14/14‐Helix Formation in 2:1 α/β‐Hybrid Peptides Containing Bicyclo[2.2.2]octane Ring Constraints
Authors: Legrand Baptiste , André Christophe , Moulat Laure , Didierjean Claude , Hermet Patrick , Bantignies Jean‐Louis , Martinez Jean , Amblard Muriel , Calmès Monique
Published: June 2016

The highly constrained β‐amino acid ABOC induces different types of helices in β urea and 1:1 α/β amide oligomers. The latter can adopt 11/9‐ and 18/16‐helical folds depending on the chain length in solution. Short peptides alternating proteinogenic α‐amino acids and ABOC in a 2:1 α/β repeat pattern adopted an unprecedented and stable 12/14/14‐helix. The structure was established through extensive NMR, molecular dynamics, and IR studies. While the 1:1 α‐AA/ABOC helices diverged from the canonical α‐helix, the helix formed by the 9‐mer 2:1 α/β‐peptide allowed the projection of the α‐amino acid side chains in a spatial arrangement according to the α‐helix. Such a finding constitutes an important step toward the conception of functional tools that use the ABOC residue as a potent helix inducer for biological applications.
Synthesis of Stable Diarylpalladium(II) Complexes: Detailed Study of the Aryl–Aryl Bond‐Forming Reductive Elimination
Authors: Gensch Tobias , Richter Nils , Theumer Gabriele , Kataeva Olga , Knölker Hans‐Joachim
Published: June 2016

The synthesis of diarylpalladium(II) complexes by twofold aryl C−H bond activation was developed. These intermediates of oxidative cyclization reactions are stabilized by chelation with acetyl groups while still maintaining sufficient reactivity to study their reductive elimination. Four distinct triggers were found for the reductive elimination of these complexes to dibenzofurans and carbazoles. Thermal elimination occurs at very high temperatures, whereas ligand‐promoted and oxidatively induced reductive eliminations proceed readily at room temperature. Under these conditions, no isomerization occurs. In contrast, weak Brønsted acids, such as acetic acid, lead to a sequence of proto‐demetalation, isomerization to a κ3‐diarylpalladium(II) complex, and reductive elimination to non‐symmetrical cyclization products.
ChemInform Abstract: Ni3Cl2+x(OH)4‐x·2H2O: Structural, Thermal, Spectral, and Magnetic Properties in Dependence of the Chloride Content.
Authors: Bette Sebastian , Dinnebier Robert E. , Kremer Reinhard K. , Freyer Daniela
Published: June 2016

Ni3Cl2+x(OH)4‐x·2H2O (x = 0.26, 0.48, 0.82) are prepared by treating β‐Ni(OH)2 or NaOH with conc.
ChemInform Abstract: Electrical Properties, Conduction Mechanism and Modulus of Diphosphate Compounds.
Authors: Ben Taher Y. , Moutia N. , Oueslati A. , Gargouri M.
Published: June 2016

RbAlP2O7 is synthesized by solid state reaction of stoichiometric mixtures of Rb2CO3, Al2O3, and NH4H2PO4 (573 and 1073 K, 8 h each) and characterized by powder XRD and electrical conductivity measurements.
ChemInform Abstract: Single Step Hydrothermal Synthesis of Beyerite, CaBi2O2(CO3)2 for the Fabrication of UV‐Visible Light Photocatalyst BiOI/CaBi2O2(CO3)2.
Authors: Malik Vidhu , Pokhriyal Meenakshi , Uma S.
Published: June 2016

Beyerite, CaBi2O2(CO3)2, is hydrothermally synthesized from Bi(NO3)3 dissolved in ethylene glycol, CaCO3, and Na2CO3 (autoclave, H2O, 140 °C, 72 h).
ChemInform Abstract: Tuning the Activity of Pt Alloy Electrocatalysts by Means of the Lanthanide Contraction.
Authors: Escudero‐Escribano Maria , Malacrida Paolo , Hansen Martin H. , Vej‐Hansen Ulrik G. , Velazquez‐Palenzuela Amado , Tripkovic Vladimir , Schiotz Jakob , Rossmeisl Jan , Stephens Ifan E. L. , Chorkendorff Ib
Published: June 2016

The oxygen reduction reaction (ORR) is investigated on sputter‐cleaned polycrystalline Pt5M (M: La, Ce Sm, Gd, Tb, Dy, Tm, Ca) catalyst cathodes of polymer electrolyte membrane fuel cells.
ChemInform Abstract: Neutron Diffraction Studies of the Na‐Ion Battery Electrode Materials NaCoCr2(PO4)3, NaNiCr2(PO4)3, and Na2Ni2Cr(PO4)3.
Authors: Ben Yahia H. , Essehli R. , Avdeev M. , Park J.‐B. , Sun Y.‐K. , Al‐Maadeed M. A. , Belharouak I.
Published: June 2016

NaCoCr2(PO4)3 (I), NaNiCr2(PO4)3 (II), and Na2Ni2Cr(PO4)3 (III) are prepared by sol‐gel reaction of stoichiometric amounts of Na(OAc), Co(OAc)2, Ni(OAc)2, Cr(NO3)3, and NH4H2PO4 aqueous solutions followed by evaporation at 90 °C and multiple firing in air (1.
ChemInform Abstract: Asymmetric Catalytic Formation of Quaternary Carbons by Iminium Ion Trapping of Radicals.
Authors: Murphy John J. , Bastida David , Paria Suva , Fagnoni Maurizio , Melchiorre Paolo
Published: June 2016

A combination of photoredox and asymmetric organic catalysis allows enantioselective radical conjugate additions to β,β‐disubstituted cyclic enones affording quaternary carbon stereocenters under mild reaction conditions.
ChemInform Abstract: Synthesis of Chiral S,N‐Thioimidazoline Ligands for Palladium‐Catalyzed Asymmetric Allylic Alkylations.
Authors: Hao Xin‐Qi , Shen Ming‐Zhan , Jian Ning‐Ge , Pang Wei , Shen Xiao‐Jing , Zhu Xinju , Song Mao‐Ping
Published: June 2016

Chiral S,N‐thioimidazoline ligands are synthesized, which exhibit high catalytic activity (yields up to 94%) and enantioselection (up to 86% e.e.) in Pd‐catalyzed asymmetric allylic alkylation reactions.
ChemInform Abstract: Chiral Copper‐Catalyzed Asymmetric Monoarylation of Vicinal Diols with Diaryliodonium Salts.
Authors: Hamaguchi Norihisa , Kuriyama Masami , Onomura Osamu
Published: June 2016

Chiral Cu(II)—Ph‐box complexes catalyze the asymmetric desymmetrization of meso‐1,2‐diols to furnish optically active β‐aryloxy alcohols in moderate to high yields and enantioselectivities.
ChemInform Abstract: Synthesis of Polysubstituted 2‐Iodoindenes via Iodonium‐Induced Cyclization of Arylallenes.
Authors: Grandclaudon Charlotte , Michelet Veronique , Toullec Patrick Y.
Published: June 2016

A new chemo‐ and regioselective iodocarbocyclization of allenylarenes is presented.
ChemInform Abstract: Potassium Phosphate‐Catalyzed Chemoselective Reduction of α‐Keto Amides: Route to Synthesize Passerini Adducts and 3‐Phenyloxindoles.
Authors: Muthukumar Alagesan , Mamillapalli N. Chary , Sekar Govindasamy
Published: June 2016

A highly chemoselective reduction of α‐keto amides towards α‐hydroxy amides is developed.
ChemInform Abstract: Indium Powder as the Reducing Agent in the Synthesis of 2‐Amino‐1,1′‐biphenyls.
Authors: Elumalai Vijayaragavan , Bjoersvik Hans‐Rene
Published: June 2016

The simple In‐based protocol for the reduction of 2‐nitrobiphenyls tolerates a variety of functional groups and gives high yields of the target 2‐amino derivatives.
ChemInform Abstract: Dual Oxidation/Bromination of Alkylbenzenes.
Authors: Aborways Marwa M. , Moran Wesley J.
Published: June 2016

In the presence of inexpensive oxidant Oxone, NaBr is used to functionalize a range of simple alkylbenzenes with up to four C—H bonds being involved.
ChemInform Abstract: Iridium(I) Complexes Bearing a Noninnocent PNP‐Pincer‐Type Phosphaalkene Ligand: Catalytic Application in the Base‐Free N‐Alkylation of Amines with Alcohols.
Authors: Chang Yung‐Hung , Tanigawa Ippei , Taguchi Hiro‐omi , Takeuchi Katsuhiko , Ozawa Fumiyuki
Published: June 2016

Newly synthesized iridium(I) complexes are used as effective and selective catalysts for the alkylation of several amines with alcohols.
ChemInform Abstract: Ruthenium‐Catalyzed Intermolecular Direct Silylation of Unreactive C(sp3)—H Bonds.
Authors: Li Wei , Huang Xiaolei , You Jingsong
Published: June 2016

This is the first Ru‐catalyzed silylation of unreactive, aliphatic C(sp3)—H bonds.
ChemInform Abstract: Palladium‐Free Sonogashira‐Type Cross‐Coupling Reaction of Bromoisoxazolines or N‐Alkoxyimidoyl Bromides and Alkynes.
Authors: Probst N. P. , Deprez B. , Willand N.
Published: June 2016

The newly developed protocol employs catalytic amount of Cu(I), a non‐toxic phenanthroline‐type ligand and tolerates a range of electron‐poor and electron‐rich phenylacetylene derivatives as well as aliphatic acetylenes (II).
ChemInform Abstract: Rhodium‐Catalyzed C—H Bond Functionalization with Amides by Double C—H/C—N Bond Activation.
Authors: Meng Guangrong , Szostak Michal
Published: June 2016

A novel procedure is elaborated for the Rh‐catalyzed alkylation, alkenylation, and (hetero)arylation of benzo[h]quinoline (I), heterobiaryls (VI), and ketone (IX) with amides such as (II) and (IV).
ChemInform Abstract: Easy Removal of N‐Carboxybenzyl (Cbz) Protective Group by Low‐Carbon Alcohol.
Authors: Song Guo‐Qiang , Qin Feng , Huang Xian‐Feng , Lv Xiao‐Bing , Yang Bei
Published: June 2016

This new highly efficient method for the deprotection of imidazoles, benzimidazoles, and pyrazoles is presented using aliphatic C1‐C4 alcohols and trimethylamine at room temperature.
ChemInform Abstract: One‐Pot Synthesis of 1H‐Isochromenes and 1,2‐Dihydroisoquinolines by a Sequential Isocyanide‐Based Multicomponent/Wittig Reaction.
Authors: Wang Long , Guan Zhi‐Rong , Ding Ming‐Wu
Published: June 2016

Passerini or Ugi condensations, coupled with an intramolecular Wittig reaction give access to the title compounds.
ChemInform Abstract: Phosphine‐ and Copper‐Free Palladium Catalyzed One‐Pot Four‐Component Carbonylation Reaction for the Synthesis of Isoxazoles and Pyrazoles.
Authors: Iranpoor Nasser , Firouzabadi Habib , Etemadi‐Davan Elham
Published: June 2016

This facile one‐pot protocol allows the intermediary generation of Sonogashira carbonylative coupling products which undergo ring closure with hydrazine derivatives or hydroxylamine hydrochloride.
ChemInform Abstract: High trans Kinetic Selectivity in Ruthenium‐Based Olefin Cross‐Metathesis Through Stereoretention.
Authors: Johns Adam M. , Ahmed Tonia S. , Jackson Bradford W. , Grubbs Robert H. , Pederson Richard L.
Published: June 2016

The first kinetically controlled, highly trans‐selective (<98%) olefin cross‐metathesis reaction is performed utilizing Ru‐based catalysts.
ChemInform Abstract: Nickel‐Catalyzed Bis‐Allylation of Activated Nucleophiles with Allyl Alcohol.
Authors: Blieck Remi , Azizi Mohamed Salah , Mifleur Alexis , Roger Maxime , Persyn Clement , Sauthier Mathieu , Bonin Helene
Published: June 2016

Different combinations which contain a Ni compound are tested and the reaction is found to be best promoted by the Ni(cod)2/dppb system.
ChemInform Abstract: Reductive Cyclopropanations Catalyzed by Dinuclear Nickel Complexes.
Authors: Zhou You‐Yun , Uyeda Christopher
Published: June 2016

Dichloromethane is utilized as methylene source in cyclopropanation reactions in the presence of mild reductants catalyzed by dinuclear Ni complexes supported by naphthyridine‐diimine ligands.
ChemInform Abstract: Fabrication of Ultrafine Palladium Phosphide Nanoparticles as Highly Active Catalyst for Chemoselective Hydrogenation of Alkynes.
Authors: Zhao Ming
Published: June 2016

The title catalyst is applied for the hydrogenation of terminal and internal alkynes to produce the corresponding alkenes with high yields and chemoselectivity.
ChemInform Abstract: Selective C—H Functionalization of Electron‐Deficient Aromatics by Carbamoylsilanes: Synthesis of Aromatic Carbinolamines or Amides.
Authors: Liu Yanhong , Cao Pei , Chen Jianxin
Published: June 2016

A simple protocol is developed for the catalyst‐free reaction of electron‐deficient arenes with carbamoyl silanes to afford carbinolamines.
ChemInform Abstract: Copper‐Catalyzed Tandem A3‐Coupling—Isomerization—Hydrolysis Reactions of Aldehydes and Terminal Alkynes Leading to Chalcones.
Authors: Zhao Yingwei , Song Qiuling
Published: June 2016

Rare examples for an A3‐coupling leading to chalcones are reported.
ChemInform Abstract: Direct Transformation of Ethylarenes into Primary Aromatic Amides with N‐Bromosuccinimide and I2—Aqueous NH3.
Authors: Shimokawa Shohei , Kawagoe Yuhsuke , Moriyama Katsuhiko , Togo Hideo
Published: June 2016

A novel two‐step procedure is elaborated for the conversion of ethylarenes into primary amides.
ChemInform Abstract: Mild, Efficient, and Environmentally Friendly Synthesis of Symmetrical N,N′‐Alkylidenebisamides under Solvent‐Free Conditions Catalyzed by H7 [(P2W17O61)FeIII (H2O)].
Authors: Tayebee R. , Maleki B. , Zonoz F. M. , Kakhki R. M. , Kunani T.
Published: June 2016

The title compounds are prepared by environmentally friendly condensation of various aliphatic or aromatic aldehydes with benzamide.
ChemInform Abstract: Indium‐Catalyzed Reductive Sulfidation of Esters by Using Thiols: An Approach to the Diverse Synthesis of Sulfides.
Authors: Miyazaki Takahiro , Kasai Shinsei , Ogiwara Yohei , Sakai Norio
Published: June 2016

A reaction mechanism involving O,S‐ and S,S‐acetals as relevant intermediates is proposed by using Hammett plot results together with a series of control experiments.
ChemInform Abstract: Silver‐Mediated Trifluoromethylthiolation—Iodination of Arynes.
Authors: Zeng Yuwen , Hu Jinbo
Published: June 2016

The one‐pot reaction of symmetrical arynes, generated in situ from precursors (I), with trifluoromethylthiosilver and 1‐iodophenylacetylene leads to o‐trifluoromethylthiolated iodoarenes (III), which can be readily converted into Yagupolskii—Umemoto‐type electrophilic trifluoromethylation reagents such as (VI).
ChemInform Abstract: Oxysulfonylation of Alkenes with Sulfonyl Hydrazides under Transition‐Metal‐Free Conditions
Authors: Liu Congrong , Ding Lianghui , Guo Guang , Liu Weiwei
Published: June 2016

affording structurally diverse β‐keto sulfones
ChemInform Abstract: Copper‐Mediated Aerobic (Phenylsulfonyl)difluoromethylation of Arylboronic Acids with Difluoromethyl Phenyl Sulfone.
Authors: Li Xinjin , Zhao Jingwei , Hu Mingyou , Chen Dingben , Ni Chuanfa , Wang Limin , Hu Jinbo
Published: June 2016

The reagent “PhSO2CF2Cu” is generated in the reaction from sulfone (I) and it further reacts with aryl‐ and heteroarylboronic acids to afford the desired products.
ChemInform Abstract: Oxygenative and Dehydrogenative [3 + 3] Benzannulation Reactions of α,β‐Unsaturated Aldehydes and γ‐Phosphonyl Crotonates Mediated by Air: Regioselective Synthesis of 4‐Hydroxybiaryl‐2‐carboxylates.
Authors: Joshi Prabhakar Ramchandra , Nanubolu Jagadeesh Babu , Menon Rajeev S.
Published: June 2016

The combination of α,β‐unsaturated aldehydes and a widely used Wadsworth‐Emmons reagent leads to the formation of a phenol framework.
ChemInform Abstract: A Photo‐Induced C—C Bond Formation Methodology to Construct Tetrahydrofluorenones and Their Related Structures.
Authors: Cai Shujun , Xiao Zheming , Ou Jinjie , Shi Yingbo , Gao Shuanhu
Published: June 2016

A previously reported photo‐Nazarov reaction is used for preparation of tetrahydrofluorenones and higher ring homologs thereof.
ChemInform Abstract: Synthesis of Fused Dibenzofuran Derivatives via Palladium‐Catalyzed Domino C—C Bond Formation and Iron‐Catalyzed Cycloisomerization/Aromatization.
Authors: Paul Kartick , Jalal Swapnadeep , Kundal Sandip , Jana Umasish
Published: June 2016

The one‐pot approach to tetracyclic dibenzofurans is achieved by Pd‐catalyzed domino carbopalladation/Suzuki coupling followed by FeCl3‐catalyzed isomerization and aromatization.
ChemInform Abstract: ZrCl4 as a New Catalyst for Ester Amidation: An Efficient Synthesis of h‐P2X7R Antagonists.
Authors: Homerin Germain , Baudelet Davy , Dufrenoy Pierrick , Rigo Benoit , Lipka Emmanuelle , Dezitter Xavier , Furman Christophe , Millet Regis , Ghinet Alina
Published: June 2016

It is shown that the catalytic activity of ZrCl4 is higher for the amidation of methyl‐pyroglutamate derivatives compared to conventional catalysts (PTSA or HCl).
ChemInform Abstract: Catalyst‐Free Dehydrative SN1‐Type Reaction of Indolyl Alcohols with Diverse Nucleophiles “on water”.
Authors: Xiao Jian , Wen Hao , Wang Liang , Xu Lubin , Hao Zhihui , Shao Chang‐Lun , Wang Chang‐Yun
Published: June 2016

Indolyl methanol derivatives undergo an efficient dehydrative SN1‐type reaction with a variety of nucleophiles using water as the solvent, affording versatile 3‐indolyl derivatives in high yields.
ChemInform Abstract: Cobalt(III)‐Catalyzed Redox‐Neutral Synthesis of Unprotected Indoles Featuring an N—N Bond Cleavage.
Authors: Lerchen Andreas , Vasquez‐Cespedes Suhelen , Glorius Frank
Published: June 2016

A Boc‐protected hydrazino moiety is employed as novel oxidizing directing group for an efficient redox‐neutral synthesis of unprotected indoles trough N—N bond cleavage.
ChemInform Abstract: Rhodium(III)‐Catalyzed Synthesis of Indole Derivatives from Pyrimidyl‐Substituted Anilines and Diazo Compounds.
Authors: Yu Ke , Liang Yujie , Li Bin , Wang Baiquan
Published: June 2016

A method for the synthesis of indole derivatives from pyrimidyl‐substituted anilines and diazo compounds via rhodium(III)‐catalyzed C—H bond activation is developed.
ChemInform Abstract: Facile and Selective Synthesis of Imidazobenzimidazoles via a Copper‐Catalyzed Domino Addition/Cycloisomerization/Coupling Process.
Authors: Xu Bingqing , Peng Bo , Cai Bili , Wang Shishi , Wang Xiaoxia , Lv Xin
Published: June 2016

Using primary propargylic amines and o‐haloarylcarbodiimides as starting materials, a variety of substituted benzo[d]imidazo[1,2‐a]imidazoles is regioselectively assembled.
ChemInform Abstract: Stereoselective Synthesis of β‐(5‐Arylthiazolyl) α‐Amino Acids and Use in Neurotensin Analogues.
Authors: Cavelier Florine , et al.
Published: June 2016

A small series of unnatural amino acids bearing a β‐arylthiazole moiety are synthesized using a pinanone Schiff base of glycine as chiral auxiliary.
ChemInform Abstract: Dithiocarbamates as an Efficient Intermediate for the Synthesis of 2‐(Alkylsulfanyl)thiazoles in Water.
Authors: Ziyaei Halimehjani Azim , Hasani Leila , Ali Alaei M. , Saidi Mohammad R.
Published: June 2016

The facile procedure allows the synthesis of thiazoles from α‐haloketones and dithiocarbamates.
ChemInform Abstract: Synthesis and Free Radical Scavenging Activity of 2‐Alkyl/arylchalcogenyl‐N‐(4‐aryl‐1,3‐thiazol‐2‐yl)acetamide Compounds.
Authors: Wolf Lucas , Quoos Natalia , Mayer Joao C.P. , de Souza Diego , Sauer Andre C. , Meichtry Luana , Bortolotto Vandreza , Prigol Marina , Rodrigues Oscar E.D. , Dornelles Luciano
Published: June 2016

A variety of the title compounds are effective scavengers against the ABTS radical species but less effective on scavenging the DPPH radical.
ChemInform Abstract: Simple and Efficient Protocol for the Synthesis of Benzoxazole, Benzoimidazole and Benzothiazole Heterocycles Using Fe(III)—Schiff Base/SBA‐15 as a Nanocatalyst.
Authors: Bardajee Ghasem Rezanejade , Mohammadi Marzieh , Yari Hasan , Ghaedi Aseyeh
Published: June 2016

An eco‐friendly protocol for this condensation reaction in water with short reaction times in good to excellent yields is reported.
ChemInform Abstract: Cationic 1,2,3‐Triazolium Alkynes: Components to Enhance 1,4‐Regioselective Azide—Alkyne Cycloaddition Reactions.
Authors: Monasterio Zaira , Sagartzazu‐Aizpurua Maialen , Miranda Jose I. , Reyes Yuri , Aizpurua Jesus M.
Published: June 2016

Cationic 1,2,3‐triazolium alkynes react regioselectively with azides (II) under metal‐free thermal conditions or in an ultrafast CuAAC reaction to afford bis‐triazoles such as (III).
ChemInform Abstract: Green and Highly Efficient Synthesis of Pyranopyrazoles in Choline Chloride/Urea Deep Eutectic Solvent.
Authors: Moshtaghi Zonouz Adeleh , Moghani Davoud
Published: June 2016

The title compounds are prepared by multicomponent reaction of ethyl acetoacetate, various aryl aldehydes, malononitrile, and hydrazine hydrate using chinoline chloride/urea as a dual catalyst and solvent.
ChemInform Abstract: Convenient Access to Di‐ and Trifluoroethylamines for Lead Structure Research.
Authors: Deutsch Amrei , Wagner Christian , Deutsch Carl , Hoffmann‐Roeder Anja
Published: June 2016

The title compounds are obtained by addition of functionalized Grignard reagents to di‐ and trifluoromethylated N‐aryl‐substituted N,O‐acetals.
ChemInform Abstract: A Convenient Synthesis of 1‐Alkoxy‐2‐alkyl‐1,2‐dihydroisoquinoline‐3,4‐diones Utilizing the Reaction of 2‐(Dialkoxymethyl)phenyllithiums with Dimethyl Oxalate.
Authors: Kobayashi Kazuhiro , Honda Yuuya , Kuroda Minami
Published: June 2016

The title compounds are prepared by an easy three‐step sequence under mild reaction conditions.
ChemInform Abstract: Highly Convergent Synthesis of Intensively Blue Emissive Furo[2,3‐c]isoquinolines by a Palladium‐Catalyzed Cyclization Cascade of Unsaturated Ugi Products.
Authors: Moni Lisa , Gers‐Panther Charlotte F. , Anselmo Manuel , Mueller Thomas J. J. , Riva Renata
Published: June 2016

An approach to the unusual furo[2,3‐c]isoquinoline scaffold is presented.
ChemInform Abstract: N‐Bromo‐Succinimide Promoted Synthesis of β‐Carbolines and 3,4‐Dihydro‐β‐carbolines from Tetrahydro‐β‐carbolines.
Authors: Hati Santanu , Sen Subhabrata
Published: June 2016

The oxidative dehydrogenation of tetrahydro‐β‐carbolines (I) and (III) using NBS to afford title compounds (II) and (IV), respectively, is described.
ChemInform Abstract: Keeping it Small, Polar, and Non‐Flat: Diversely Functionalized Building Blocks Containing the Privileged 5,6,7,8‐Tetrahydro[1,2,4]triazolo[4,3‐a]‐ and [1,5‐a]pyridine Cores.
Authors: Mishchuk Alexander , Shtil Natalia , Poberezhnyk Mykola , Nazarenko Konstiantyn , Savchenko Timur , Tolmachev Andrey , Krasavin Mikhail
Published: June 2016

Different sets of functionalized building blocks, e.
ChemInform Abstract: Metal‐Free Synthesis of Indolizines Through Oxidative C—C and C—N Bond Formations of C(sp3)—H Bonds.
Authors: Reddy N. Naresh Kumar , Mohan Darapaneni Chandra , Adimurthy Subbarayappa
Published: June 2016

Title compounds such as (III), (V), (VII) and (IX) are formed by reaction of 2‐pyridyl acetates (I) with alkynes and alkenes without metal, oxidant, and base.
ChemInform Abstract: Implications of Dynamic Imine Chemistry for the Sustainable Synthesis of Nitrogen Heterocycles via Transimination Followed by Intramolecular Cyclization.
Authors: Laha Joydev K. , Satyanarayana Tummalapalli K. S. , Jethava Krupal P.
Published: June 2016

Quinazolines and benzothiazoles are prepared by a convergent, efficient and metal‐free transimination/intramolecular cyclization tandem reaction.
ChemInform Abstract: Palladium‐Catalyzed Modular Synthesis of Substituted Piperazines and Related Nitrogen Heterocycles.
Authors: Montgomery Thomas D. , Rawal Viresh H.
Published: June 2016

This novel method for the synthesis of substituted piperazine‐and piperazinone‐type compounds proceeds by a palladium‐catalyzed decarboxylative cyclization of propargyl carbonates with bis‐nitrogen nucleophiles with good functional group tolerance.
ChemInform Abstract: Synthesis of Quinoxaline Derivatives via Tandem Oxidative Azidation/Cyclization Reaction of N‐Arylenamines
Authors: Ma Haichao , Li Dianjun , Yu Wei
Published: June 2016

28 examples
ChemInform Abstract: A Serendipitous Synthesis of 11a‐Hydroxy‐11,11a‐dihydrobenzo[e]indeno[2,1‐b] [1,4]diazepine‐10,12‐dione Derivatives by Condensation of 2‐Aminobenzamides with Ninhydrin in Water.
Authors: Devi Rajkumari Vijilata , Garande Ashok M. , Maity Dilip K. , Bhate Prakash M.
Published: June 2016

Ninhydrin undergoes an unprecedented condensation reaction with benzamides (I) to give novel diazepine derivatives.
ChemInform Abstract: Copper‐Catalyzed Regioselective Hydroboration of Terminal Alkynes in Aqueous Medium.
Authors: Yao Zi‐Jian , Hong Shibin , Zhang Wei , Liu Mengyan , Deng Wei
Published: June 2016

The regioselectivity of the hydroboration reaction is significantly influenced by the alkyne substituent.
ChemInform Abstract: Pyridyl Directed Catalyst‐Free trans‐Hydroboration of Internal Alkynes.
Authors: Yuan Kang , Suzuki Naoya , Mellerup Soren K. , Wang Xiang , Yamaguchi Shigehiro , Wang Suning
Published: June 2016

Trans‐hydroboration of internal alkynes with 9‐BBN produces five‐membered BN‐heterocycles in a straightforward manner.
ChemInform Abstract: Microwave‐Assisted Copper‐ and Palladium‐Catalyzed Sonogashira‐Type Coupling of Aryl Bromides and Iodides with Trimethylsilylacetylene.
Authors: Lei Yonghua , Hu Tianhan , Wu Xingsen , Wu Yue , Xiang Hua , Sun Haopeng , You Qidong , Zhang Xiaojin
Published: June 2016

The use of microwave irradiation is found to significantly improve the reaction yield and shorten the reaction time.
ChemInform Abstract: Synthesis of a Luminescent Azaphosphole.
Authors: Wu Shanshan , Rheingold Arnold L. , Golen James A. , Grimm Alexandra B. , Protasiewicz John D.
Published: June 2016

A carbazole‐based azaphosphole (VI) is prepared by acid‐catalyzed dehydrocyclization of 1‐phosphino‐9H‐carbazole (IV) with toluyl chloride (V).
ChemInform Abstract: An Efficient, Three‐Component Synthesis of Isoindolin‐1‐one‐3‐phosphonates under Mild and Solvent‐Free Conditions.
Authors: Adib Mehdi , Sheikhi Ehsan , Yazzaf Rozita , Bijanzadeh Hamid Reza , Mirzaei Peiman
Published: June 2016

A facile protocol allows the synthesis of the title phosphonates from 2‐formylbenzoic acid, amines, and trialkylphosphite at room temperature under catalyst‐ and solvent‐free conditions.
ChemInform Abstract: Microwave‐Assisted Direct Esterification of Cyclic Phosphinic Acids in the Presence of Ionic Liquids.
Authors: Kiss Nora Zsuzsa , Keglevich Gyoergy
Published: June 2016

The efficiency of the microwave‐assisted direct esterification of cyclic phosphinic acids, e.g. (I), (IV), and (VI), is significantly enhanced by adding 10% of an ionic liquid to the reaction mixture prior to irradiation.
ChemInform Abstract: Dihydro‐β‐agarofuran Sesquiterpenes from Celastraceae Species as Antitumor‐Promoting Agents: Structure—Activity Relationship.
Authors: Nunez Marvin J. , Jimenez Ignacio A. , Mendoza Cristina R. , Chavez‐Sifontes Marvin , Martinez Morena L. , Ichiishi Eiichiro , Tokuda Ryo , Tokuda Harukuni , Bazzocchi Isabel L.
Published: June 2016

Five dihydro‐β‐agarofuran sesquiterpenes, chiapene A (Ia), chiapene B (Ib), chiapene C (II), chiapene D (III), and chiapene E (IV) are isolated from Maytenus chiapensis and tested for their inhibitory effects on Epstein—Barr virus early antigen activation.
ChemInform Abstract: Structure Revision of Caesalpinistas A and B and Isolation of a New Furanoditerpenoid from the Cotyledons of Caesalpinia decapetala var. japonica.
Authors: Kamikawa Sayuri , Ohta Emi , Nehira Tatsuo , Omura Hisashi , Ohta Shinji
Published: June 2016

The new diterpenoid, deoxycaesaljaponin A (I) is isolated along with the known caesalpinista B.
ChemInform Abstract: Total Synthesis of (.+‐.)‐Scopolamine: Challenges of the Tropane Ring.
Authors: Nocquet Pierre‐Antoine , Opatz Till
Published: June 2016

Two approaches to the title compound (I) are investigated which afford comparable overall yields.
ChemInform Abstract: Synthesis of Azacyclic Nucleoside Analogues via Asymmetric [3 + 2] Cycloaddition of 9‐(2‐Tosylvinyl)‐9H‐purines.
Authors: Zhang Dan‐Jie , Xie Ming‐Sheng , Qu Gui‐Rong , Gao Yao‐Wei , Guo Hai‐Ming
Published: June 2016

An efficient catalytic system of Cu(MeCN)4ClO4 and a chiral ferrocene ligand is applied for the asymmetric [3 + 2] cycloaddition of 9‐(2‐tosylvinyl)‐9H‐purines with azomethine ylides (II).
ChemInform Abstract: Talaroketals A and B, Unusual Bis(oxaphenalenone) Spiro and Fused Ketals from the Soil Fungus Talaromyces stipitatus ATCC 10500.
Authors: Zang Yi , Genta‐Jouve Gregory , Retailleau Pascal , Escargueil Alexandre , Mann Stephane , Nay Bastien , Prado Soizic
Published: June 2016

Talaroketals A (I) and B (II) are isolated from the soil fungus.
ChemInform Abstract: Surface Control of a Photoresponsive Self‐Assembled Monolayer and Selective Deposition of Ag Nanoparticulate Ink
Authors: Konishi Tsubasa , Yamaguchi Kazuo
Published: June 2016

A highly hydrophobic self‐assembled monolayer (SAM) with high photosensitivity to soft UV (λ = 365 nm) is formed on thermally surface‐oxidized silicon wafers by a silane coupling agent bearing a 2‐nitrobenzyl carbamate moiety.
ChemInform Abstract: When Chemistry Meets Biology: The Case of Aluminum — A Review
Authors: Kisnieriene Vilma , Lapeikaite Indre
Published: June 2016

Review: 98 refs.
ChemInform Abstract: Coordination Compounds of Rare‐Earth Metal Thiocyanates
Authors: Petrosyants S. P.
Published: June 2016

Review: 62 refs.
ChemInform Abstract: Regularities in the Crystal Structures of Heterocationic Octacyanometallates(IV) Molybdenum and Tungsten
Authors: Semenyshyn Dariya , Typilo Iryna , Gladyshevskii Roman , Starchevskyy Volodymyr
Published: June 2016

Review: 18 refs.
ChemInform Abstract: Cyclodiphosphazanes in Metal Organic Frameworks
Authors: Balakrishna M. S.
Published: June 2016

Review: 27 refs.
ChemInform Abstract: Polyfunctional Zinc and Magnesium Organometallics for Organic Synthesis: Some Perspectives
Authors: Benischke Andreas D. , Ellwart Mario , Becker Matthias R. , Knochel Paul
Published: June 2016

Review: 31 refs.+subrefs.
ChemInform Abstract: Advanced Synthetic Strategies for Constructing Quinazolinone Scaffolds
Authors: Rohokale Rajendra S. , Kshirsagar Umesh A.
Published: June 2016

Review: [69 refs.
ChemInform Abstract: Development of a Pseudo‐Intramolecular Process
Authors: Nishiwaki Nagatoshi
Published: June 2016

Review: [33 refs.
ChemInform Abstract: Silicon Carbide Foam as a Porous Support Platform for Catalytic Applications
Authors: Duong‐Viet Cuong , Ba Housseinou , El‐Berrichi Zora , Nhut Jean‐Mario , Ledoux Marc J. , Liu Yuefeng , Pham‐Huu Cuong
Published: June 2016

Review: 121 refs.
ChemInform Abstract: Lactide Synthesis and Chirality Control for Polylactic Acid Production
Authors: Van Wouwe Pieter , Dusselier Michiel , Vanleeuw Evelien , Sels Bert
Published: June 2016

Review: [67 refs.
ChemInform Abstract: Photocatalysts in Polymerization Reactions
Authors: Zivic Nicolas , Bouzrati‐Zerelli Mariem , Kermagoret Anthony , Dumur Frederic , Fouassier Jean‐Pierre , Gigmes Didier , Lalevee Jacques
Published: June 2016

Review: [136 refs.
ChemInform Abstract: Cubic Polyhedral Oligomeric Silsesquioxane Based Functional Materials: Synthesis, Assembly, and Applications
Authors: Ye Qun , Zhou Hui , Xu Jianwei
Published: June 2016

Review: [61 refs.
ChemInform Abstract: Recent Developments in Organocatalytic Dynamic Kinetic Resolution
Authors: Pellissier Helene
Published: June 2016

Review: [62 refs.
ChemInform Abstract: Recent Advances and Perspectives in the Synthesis of Bioactive Coumarins
Authors: Calcio Gaudino E. , Tagliapietra S. , Martina K. , Palmisano G. , Cravotto G.
Published: June 2016

Review: 72 refs.
ChemInform Abstract: Application of Corey—Bakshi—Shibata, Corey—Kim, Corey—Seebach, Corey—Winter, Corey—Link, and Corey—Ganem—Gilman in Organic and Total Synthesis.
Authors: Heravi Majid M. , Asadi Shima , Nazari Niousha , Lashkariani Boshra Malekzadeh
Published: June 2016

Review: 117 refs.
ChemInform Abstract: Interplay of Superconductivity and Magnetism in a t‐t′‐J Approach to High Tc Cuprates
Authors: Marchetti P. A.
Published: June 2016

Review: 15 refs.
ChemInform Abstract: Multiscale Adsorption and Transport in Hierarchical Porous Materials
Authors: Coasne Benoit
Published: June 2016

Review: 172 refs.
ChemInform Abstract: Cationic Noncovalent Interactions: Energetics and Periodic Trends
Authors: Rodgers M. T. , Armentrout P. B.
Published: June 2016

Review: 404 refs.
ChemInform Abstract: Recent Insight into the Biological Activities of Synthetic Xanthone Derivatives
Authors: Shagufta Shagufta , Ahmad Irshad
Published: June 2016

Review: 105 refs.
ChemInform Abstract: A Review of Harvesting Clean Fuels from Enzymatic CO2 Reduction
Authors: Sultana Sabiha , Sahoo Prakash Chandra , Martha Satyabadi , Parida Kulamani
Published: June 2016

Review: summary on single enzyme, multi enzymatic and semiconducting nanomaterial integrated enzymatic systems for CO2 conversion to clean fuels; 134 refs.
ChemInform Abstract: Pretreatment and Conversion of Lignocellulose Biomass into Valuable Chemicals
Authors: Putro Jindrayani Nyoo , Soetaredjo Felycia Edi , Lin Shi‐Yow , Ju Yi‐Hsu , Ismadji Suryadi
Published: June 2016

Review: 252 refs.
ChemInform Abstract: Perspectives on Zeolite‐Encapsulated Metal Nanoparticles and Their Applications in Catalysis
Authors: Farrusseng David , Tuel Alain
Published: June 2016

Review: 155 refs.
ChemInform Abstract: Nature‐Inspired Optimization of Hierarchical Porous Media for Catalytic and Separation Processes
Authors: Trogadas Panagiotis , Nigra Michael M. , Coppens Marc‐Olivier
Published: June 2016

Review: 98 refs.
ChemInform Abstract: Emerging Supramolecular Therapeutic Carriers Based on Host—Guest Interactions
Authors: Karim Anis Abdul , Dou Qingqing , Li Zibiao , Loh Xian Jun
Published: June 2016

Review: 86 refs.
THE ELECTRON DENSITY PROFILE INVERSION FOR INCOMPLETELY DEVELOPED CASE OF F1 LAYER
Authors: Na WEI , Wen LIU , Zhuan‐Xia LU , Jing FENG , Long‐Quan YANG , Wen‐Ling GUO
Published: June 2016

The electron density profile inversion from vertical incidence ionograms is essential for research in ionospheric structures and movements, wave propagation and space weather applications, hence has gathered very wide attention. The echo trace of incompletely developed F1 layer is common in vertical incidence ionograms, and it is usually expressed as smooth transition from F1 layer to F2 layer, not a cusp appeared at the critical frequency of F1 layer. However, the existing ionospheric models and inversion algorithms are generally intended for the completely developed F1 layer with the assumptions of a parabolic profile and an infinite slope at the peak of F1 layer, which are not suitable for the profile of incompletely developed F1 layer which achieves the maximum electron density of F1 layer and enters F2 layer at the peak of F1 layer and has a finite slope. Consequently, an F1 layer electron density profile model based on the shifted Chebyshev polynomial for incompletely developed case of F1 layer is introduced with a parameter named as the model setting critical frequency. Taking into account the profile smoothness, an electron density profile inversion algorithm with constrained optimization F1 and F2 layer parameters based on the model mentioned above is proposed. The validity of the model and the inversion algorithm is analyzed through the simulation, and the effectivity of the proposed algorithm is further verified by the comparison between the synthesized vertical sounding & oblique sounding traces and the measured data.
ANALYSIS OF NORMALIZED TIME‐FREQUENCY RESPONSE SPECTRA FOR THREE SEISMIC RECORDS
Authors: Zhi‐Gang QIU , Qi‐Feng LUO
Published: June 2016

Time‐Frequency Response Spectrum (TFRS) is a three‐dimensional spectrum, which includes three main characteristics of ground motion: amplitude, frequency characteristic and duration. Based on it, Normalized Time‐Frequency Response Spectrum (NTFRS) was proposed and the NTFRS of three typical seismic waves were calculated. The comparison of three NTFRS shows that spectra amplitudes distributed along period axis and duration axis are different from each other; the large difference may cause different effect on the structures. One 12‐storey reinforced concrete frame structure was analyzed by using elastic‐plastic time‐history analysis method. The comparison of the seismic response, structural damage curve and NTFRS of input ground motion shows that the maximum seismic response of structure might not be the cause of its collapse. It implies that the traditional response spectrum theory has limitation because in the theory the maximum elastic response of structures is used to make seismic design. It could be concluded that the Normalized Time‐Frequency Response Spectrum is better for analyzing the characteristics of ground motions and the structural failure mechanism in the earthquakes.
SYNTHETIC APERTURE IMAGING IN ADVANCED DETECTION OF ROADWAY USING MINE TRANSIENT ELECTROMAGNETIC METHOD
Authors: Jiu‐Long CHENG , Ding CHEN , Guo‐Qiang XUE , Hao QIU , Xiang‐Tong ZHOU
Published: June 2016

During the data processing and interpretation of mine transient electromagnetic method (MTEM), in order to improve the identification of the geo‐electrical interface between low resistivity abnormal body and surrounding rock in advanced detection, transient electromagnetic field was transformed to pseudo‐seismic wave‐field based on the function relationship between spreading electromagnetic field and seismic wave‐field in whole‐space. Meanwhile, the signal of pseudo‐seismic after being transformed was processed with correlative stack to strengthen the amplitude and improve signal‐noise‐ratio (SNR) using the synthetic aperture imaging (SAI). The data of different detection directions on one surveying point in MTEM were imaged as aperture data, which would highlight weak abnormality and improve SNR. In addition, the application effect of SAI was testified with the in‐site advanced detection in roadway using MTEM. The results showed that the SAI of the MTEM could improve SNR of the electrical interface information and highlight the geometrical resolution to increase exploration accuracy. The technique is significant theoretically and practically in accurate advanced detection of aquifer structure by MTEM.
USING OBS TELESEISMIC RECEIVER FUNCTIONS TO INVERT THE LITHOSPHERIC STRUCTURE—A CASE STUDY OF THE SOUTHWESTERN SUBBASIN IN THE SOUTH CHINA SEA
Authors: Hao HU , Ai‐Guo RUAN , Qin‐Yu YOU , Jia‐Biao LI , Tian‐Yao HAO , Jiang‐Ping LONG
Published: June 2016

Due to the particular seafloor environment and the special outer mechanical structure of the ocean bottom seismometer (OBS), there are some problems that have not been solved in the lithospheric structure inversion using the OBS teleseismic receiver functions. Based on the analysis of these problems, we combined the Fourier transform and wavelet analysis to suppress the non‐stationary noise to obtain a better signal‐to‐noise ratio and clearer seismic phases recorded by the OBSs at the southwestern subbasin in the South China Sea (SCS). The equipment is a broadband OBS of I‐4C type produced by the Institute of Geology and Geophysics, Chinese Academy of Sciences. We then inverted the lithospheric structure by successfully applying the receiver functions to the teleseismic data recorded at the southwestern subbasin in the SCS. The results show that it is feasible to use the receiver functions for the inversion of the lithosphere structure based on the passive observation data collected via the OBS, in which the key is to suppress the non‐stationary noise. The Moho depth at the southwestern subbasin in the SCS is 10∼12 km, with a crust thickness of 6∼8 km. The shallow crust is a low velocity layer with sediment thickness 1∼2 km, which consists of sediment and volcanic clastic breccia produced by the magma eruption after the spreading cessation. In the spreading axis center, a low S‐wave velocity zone exists at the depths of 6 km to 12 km above the Moho. We interpreted this zone as the result of partial melting of the lower crust or the presence of a magma chamber. In the same area at the depths of 17 km to 30 km, the vertical S‐wave velocity gradient is negative. We interpreted it as the result of the hot magma supply moving upward in the mantle.
Use of tyrosine kinase inhibitors to prevent relapse after allogeneic hematopoietic stem cell transplantation for patients with Philadelphia chromosome–positive acute lymphoblastic leukemia: A position statement of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation
Authors: Giebel Sebastian , Czyz Anna , Ottmann Oliver , Baron Frederic , Brissot Eolia , Ciceri Fabio , Cornelissen Jan J. , Esteve Jordi , Gorin Norbert‐Claude , Savani Bipin , Schmid Christoph , Mohty Mohamad , Nagler Arnon
Published: June 2016

Allogeneic hematopoietic stem cell transplantation (alloHSCT) is a standard of care for patients with Philadelphia chromosome (Ph)–positive acute lymphoblastic leukemia (ALL). The introduction of tyrosine kinase inhibitors (TKIs) to first‐line therapy has improved overall outcomes; however, a significant proportion of patients still relapse after alloHSCT. Posttransplant TKI maintenance was demonstrated to reduce the risk of relapse in a large retrospective study and, therefore, should be considered a valuable option. This consensus paper, written on behalf of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation, presents an overview of clinical studies on the use of TKIs after alloHSCT and proposes practical recommendations regarding the choice of TKI, treatment timing, and dosage. It is hoped that these recommendations will become the state of art in this field and, more importantly, lead to a reduction of Ph‐positive ALL relapse after alloHSCT. Cancer 2016;122:2941‐2951. © 2016 American Cancer Society.
Correction of second‐order‐diffraction errors in spectrophotometry
Authors: Xu Zhiling , Brill Michael H.
Published: June 2016

Conventional diffraction gratings are designed so that most of the light striking the grating is diffracted toward the “first‐order beam” direction, but in practice, some of the light may be diffracted towards the “second‐order beam” direction, so that the light striking a particular sensor pixel may be a combination of both first‐ and second‐order components. This causes errors in the output of diffraction‐grating based UV–visible spectrometers. A new method has been developed to correct such errors by calibrating the optical system with a UV‐excluded standard (such as an orange tile) and a UV‐included standard (such as a white tile). These two calibrations can predict the relationship between first‐order‐only signals and first‐and‐second‐order combined signals at sensor pixels (nominal wavelengths) where there is second‐order light, and thus help correct the second‐order diffraction error. This compensation method applied on the reflectance measurement of a set of color ceramic tiles showed significant improvement on the accuracy of the result. © 2016 Wiley Periodicals, Inc. Col Res Appl, 42, 189–192, 2017
Enhancing NMR Sensitivity of Natural‐Abundance Low‐γ Nuclei by Ultrafast Magic‐Angle‐Spinning Solid‐State NMR Spectroscopy
Authors: Zhang Rongchun , Chen Yitian , Rodriguez‐Hornedo Nair , Ramamoorthy Ayyalusamy
Published: June 2016

Although magic‐angle‐spinning (MAS) solid‐state NMR spectroscopy has been able to provide piercing atomic‐level insights into the structure and dynamics of various solids, the poor sensitivity has limited its widespread application, especially when the sample amount is limited. Herein, we demonstrate the feasibility of acquiring high S/N ratio natural‐abundance 13C NMR spectrum of a small amount of sample (≈2.0 mg) by using multiple‐contact cross polarization (MCP) under ultrafast MAS. As shown by our data from pharmaceutical compounds, the signal enhancement achieved depends on the number of CP contacts employed within a single scan, which depends on the T1ρ of protons. The use of MCP for fast 2D 1H/13C heteronuclear correlation experiments is also demonstrated. The significant signal enhancement can be greatly beneficial for the atomic‐resolution characterization of many types of crystalline solids including polymorphic drugs and nanomaterials.