bluuebunny/crossref_metadata_2025 huggingface dataset:
Estado nutricional, síndrome metabólico e inflamación en pacientes con enfermedad de Chagas
Authors: Albornoz María Gracia , Martínez Clara , Carías Diamela , Acosta Edgar , Carrasco Hernán J.
Published: May 2021

El propósito de este estudio fue describir la asociación entre el estado nutricional, la presencia de síndrome metabólico (SM), y el estado inflamatorio, en pacientes con Enfermedad de Chagas (ECh), atendidos en la consulta externa del Instituto de Medicina Tropical en Caracas. El estudio fue de tipo transversal y correlacional, en el cual se seleccionaron 34 pacientes a los cuales se les realizó un diagnóstico parasitológico, inmunológico y molecular de la ECh. Se evaluaron variables antropométricas, clínicas y bioquímicas, así como el SM el cual fue determinado por los criterios del III Panel estadounidense para el Tratamiento de Adultos del Programa Nacional de Educación sobre el Colesterol (ATP-III, por sus siglas en inglés). Se encontró que la mayoría de los pacientes presentaron sobrepeso u obesidad (73,5%), un porcentaje de grasa corporal (% GC) alto o muy alto (82,3%), y obesidad abdominal (61,8 %). La frecuencia de SM fue de 29,4% y más del 90% mostraron valores elevados de Proteína C Reactiva ultrasensible (PCRus). Valores más elevados del IMC se asociaron con un estadio más avanzado de la ECh. Los sujetos con presencia de ADN de Tripanosoma cruzi (T. cruzi) circulante en sangre, presentaron mayor % GC, y en su mayoría, fueron diagnosticados con SM. En conclusión, los pacientes evaluados mostraron un exceso de adiposidad, que puede favorecer el estado inflamatorio, el desarrollo de SM y la progresión de la ECh.
The purpose of the study was to describe the association between nutritional and inflammatory status and the presence of metabolic syndrome (MS) on patients with Chagas disease (CD) treated at the Outpatient Services of the Tropical Medicine Institute in Caracas, Venezuela. The study was cross-sectional and correlational. Thirty-four (34) patients were selected and a molecular, immunological, and parasitological diagnostic test was ran for Chagas disease. Anthropometric, clinic, and biochemical variables were evaluated, and the MS was determined using National Cholesterol Education Program Expert/Adult Treatment Panel III (ATP-III) criteria. The results showed a high percentage of patients overweight or presenting obesity (73.5%), a high and very high percentage of body fat (82.3%), and abdominal obesity (61.8%). The prevalence of MS was 29,4% and more than 90% of patients showed elevated values of high sensitivity C-reactive protein (hsCRP). Higher body-mass index values were associated with advanced stages of the CD. Subjects in the presence of T. cruzi DNA in the blood showed a greater percentage of body fat and, most of them, were diagnosed with MS. In conclusion, the evaluated patients showed an excess of adiposity which may favor an inflammatory status, the development of the MS, and the progress of the CD.
Migración de neutrófilos en larvas de pez cebra expuestos a extractos de sofrito de tomate
Authors: Arteaga Cristina , Bustillos Alberto , Gómez-Catalán Jesús
Published: May 2021

Este trabajo se fundamenta en la evaluación de la actividad antiinflamatoria de extractos de sofrito de tomate, así como de compuestos estándares de la dieta mediterránea, usando un modelo experimental optimizado basado en larvas de pez cebra. La migración de neutrófilos en larvas de pez cebra de 96 horas post fertilización se indujo mediante una lesión y se potenció añadiéndole lipopolisacárido, dicha migración se visualizó y cuantificó mediante análisis de imagen. El efecto antiinflamatorio del extracto de tomate y de los compuestos utilizados fue correlacionado porcentualmente por la disminución de la migración de los neutrófilos. Los resultados muestran que el extracto de tomate presentó una reducción en la migración de neutrófilos de 40 % respecto al grupo control. Por otra parte, el ácido clorogénico y la cianidina presentes en el sofrito de tomate utilizados como estándares presentaron una disminución de la migración de neutrófilos de un 66,7 % y 62,5 % respectivamente. Estos porcentajes son comparables a los resultados observados en ensayos con drogas antiinflamatorias como la indometacina y piroxicam. Los resultados muestran que el extracto de sofrito de tomate presenta posible actividad antinflamatoria demostrada por la reducción de la migración de neutrófilos, además el modelo se mostró sensible y válido para ser aplicado en matrices alimentarias complejas.
The Biography Of Abdulla Avloni, Representative Of Uzbek Literature Renaissance, From A New Perspective
Authors:   Candidate Of Philological Sciences, Department Of “PR And International Communication”, Faculty Of “International Journalism And Public Relations”, Journalism And Mass Communication University Of Uzbekistan, Artikova Yulduz Akmalovna
Published: May 2021

This article provides a new scientific analysis of the biography of Abdulla Avloni, an enlightened poet, playwright, journalist, scientist, statesman and public figure who lived and worked in the late 19th and early 20th centuries. It is well known that in the Soviet era, educated, enlightened people were persecuted as enemies of the people. Those who were shot, family members were politically persecuted as relatives of the enemy of the people. Most writers, scientists were forced to change their biographies, to hide their genealogy. In works of art, the aristocracy is portrayed in a negative light. The article analyzes the changes made to Abdulla Avloni's biography for political reasons on the basis of scientific sources and memoirs.
Socio-Geographical Aspects Of The Culture Of Nature Use Of The Population Of The Fergana Valley
Authors:   PhD, Senior Teacher Fergana State University, Faculty Of Natural Sciences, Department Of Geography, Uzbekistan, Komilova Nargizakhon
Published: May 2021

The growth of the world's population and the accelerated development of economic sectors are causing the expansion of the use of natural resources and an increase in anthropogenic pressure on them. This situation causes social and environmental problems in regions with intensively developed sectors of the economy and high population density.
Connection Between A Right Triangle And An Equal Side Triangle
Authors:   Lecturer Denau Institute Of Entrepreneurship And Pedagogy, Uzbekistan, Hikmatovich Ibragimov Husniddin
Published: May 2021

There is some evidence that a right triangle and an equilateral triangle are related. Information about Pythagorean numbers is given. The geometric meaning of the relationship between right triangles and equilateral triangles is shown. The geometric meaning of the relationship between an equilateral triangle and an equilateral triangle is shown.
Pathomorphological Characteristics Of Glandular Hyperplasia Endometry In Women According To The Data Of The Bukhara Regional Pathological Bureau
Authors:   Bukhara State Medical Institute Named After Abu Ali Ibn Sina, Uzbekistan, Bakhshillaevna Zhuraeva Gulbahor
Published: May 2021

The results of examination of 107 patients with glandular hyperplasia of the endometrium are presented. The age of women ranged from 43 to 67 years, on average it was 41.2 + 2.6 years, of which 76 patients were of reproductive age and 49 during the perimenopause. The diagnosis of glandular hyperplasia was established on the basis of morphological scraping of the uterine mucosa. The morphological forms of glandular hyperplasia of the endometrium were analyzed and a comparative analysis of the frequency of all this pathology in the Bukhara region was carried out. The results of the study showed a high growth of this pathology, the cause of which is uterine bleeding, which was confirmed by morphological examination.
Examples Of Folklore In The Textbook "OʻQish Kitobi" Of Uzbek Primary Schools
Authors:   Lecturer Of Primary Education Methodology, Jizzakh State Pedagogical Institute, Uzbekistan, Yusupovna Abdurakhmonava Dinora
Published: May 2021

The younger generation is the foundation of our future. Thus we need to pay more attention to primary education. The main part of the important task of educating primary school students is carried out in reading classes. The textbooks also cover a wide range of folklore that students love to read. Folklore includes fairy tales, epics, legends, narrations, songs, folk songs, riddles, parables, anecdotes and stories. Folklore has long been a source of education.
Policy Of Repression: Difficult And Complex Years For The People
Authors:   Doctor Of Philosophy In History (PhD), Karakalpak State University, Uzbekistan, Qu'atbaevich Jumaniyazov Damir , Jalgasbaevich Jangabaev Jumabek ,   Trainee Teacher Of The Department Of History Of Uzbekistan And Karakalpakstan, Uzbekistan
Published: May 2021

The article examines the innocent victims who were selfless representatives of the Karakalpak people, such as Ubaydulla Baoetdinov (Khan Maksim), Kutlymuratbiy (Bala biy), Inayat bolis Niyazov, Ollo'r Dustnazarov, Kasym Auebaev, Kasim Aoezov in the Bolshevik government during policy of repression. It is estimated that 70% of the representatives of the Karakalpak Autonomous Region were arrested under the name "public enemy", as a result of which the population became afraid and the policy of totalitarianism was intensified.
Ways Of Developing Marketing Programs Of Enterprises In The Context Of The Formation Of Textile Clusters
Authors:   Doctor Of Economics, Professor Of ", Asqarov Nodir Ibragimovich ,   Economics",   , Andijan State University, Uzbekistan
Published: May 2021

This article explores the experience of creating textile clusters, and also discusses the content of marketing programs of enterprises.
New Content And Composition Of Surplus Product
Authors:   Professor Tashkent State University Of Economics, Uzbekistan, Shodmonov Sherkul Shodmonovich , Abdullaeva Madina Kamilovna ,   Associate Professor, Tashkent State University Of Economics, Uzbekistan, Bababekova Dilfuza Sherkulovna ,   Candidate Of Economic Sciences, Associate Professor Tashkent Financial Institute, Uzbekistan, Mamadiyorov Olim Umarovich ,   Senior Lecturer Tashkent Financial Institute, Uzbekistan
Published: May 2021

This article deals with the issue of surplus product which is an important, tangled knot of economics that exists at all times, in all countries, in all social systems, regardless of the boundaries of time and space, causing controversy and debate among many scholars. Attempts are made to shed light on issues such as new content of the surplus product as a source of economic development, its difference from value added, its forms, mass, norm, components.
Assessment And Management Of Negative Impacts Of Foreign Direct Investment For Economies Of Central Asia
Authors:   Independent researcher (Phd) of the Academy of Public Administration under the President of the Republic of Uzbekistan, Head of the department for the implementation of information systems in JSC “Uzbekneftegaz”, Uzbekistan, Juraev Javohir
Published: May 2021

Uzbekistan has only begun to make independent steps in global economic processes. Along with Central Asian countries, Kazakhstan, Kyrgyzstan, Turkmenistan and Tajikistan, Uzbekistan’s economy and economic structure is pretty young, thus vulnerable to any unseen exogenous repercussions. We have already seen that how the Mexican Tequila crisis in 1994, the Asian crisis in 1997-98, the Russian crisis (even it was the leftover contagion from the Asian crisis) in 1998 and recent Kazakhstan real-estate crisis in summer of 2007 happened. It easy to see if we look behind capital flows. Capital flows have been heartache and headache for an economy for the last two decades. They are so mobile and volatile that can bear vicious ebbs and flow in no time at all. However, it is necessary to remember, that today it is difficult to speak of the economy of any country as about of separate island. Foreign Direct Investment is very necessary somehow, at least theoretically, to boost the economies of Central Asia. But there should be proper balance and policies to make the most of FDI inflows. An enchanted economy by enormous FDI inflows is exposed to very huge risk which might end up even with crisis!
Summary Of Evaluation And Surgical Treatment Of Hemorrhagic Stroke
Authors:   Tashkent Pediatric Medical Institute, Uzbekistan, M.M. Ruzikulov , B.Sh. Mukhammedaminov ,   Tashkent Pediatric Medical Institute, Uzbekistan, I.I. Rahimov ,   Tashkent Pediatric Medical Institute, Uzbekistan, M.I. Burnashev ,   Republican Specialized Scientific Practical Medical Center Of Neurosurgery Of Uzbekistan, Sh.O. Rasulov ,   Republican Specialized Scientific Practical Medical Center Of Neurosurgery Of Uzbekistan
Published: May 2021

Stroke is one of the leading causes of death. Every 7th patient with stroke is of a hemorrhagic nature, from which the mortality rate is 35-40%, and disability is 75%, and 10% disabled are bedridden. The disease has social impact, as it is common among working-age population. In the past three decades, neurosurgeons conducted an active search for and introduction of new methods of treatment of primary intracerebral hematomas. That is, patients with extravasations have the most pronounced neurological deficit and require prompt action to eliminate it. Thus, the admission of patients to specialized neurosurgical department, the proper selection of patients for surgery, the use in surgery minimally invasive methods and usage of modern technologies postoperative mortality does not exceed 25%, and the time from diagnosis to the possibility of a complete rehabilitation therapy is 1.5-2 weeks.
Assessment Of Some Functional Indicators Of The Oral Cavity Working In Tobacco Production
Authors:   Candidate Of Medical Sciences, Associate Professor Of The Department Of Dentistry, Faculty Of Postgraduate Education, Uzbekistan, Sharipovna Nazarova Nodira , Baizakova Sitora ,   Assistant Of The Department Of Pediatric Dentistry, Uzbekistan, Ismailova Sevinch ,   Second Year Master's Student, Samarkand State Medical Institute, Uzbekistan
Published: May 2021

To date, it has been established that 70% of people involved in tobacco growing have various diseases [4,6,]. Comparison of morbidity rates with temporary disability of workers employed in tobacco growing and the control group shows that tobacco growers get sick more often than others. The number of diseases they have is 37%, and the number of days of disability is 30% higher than in other types of agricultural work [8,4,1]. Diseases of the respiratory and gastrointestinal tract, infectious and allergic diseases, nervous and cardiovascular systems, skin and subcutaneous tissue occupy the leading place in the structure of tobacco growers' morbidity. However, there is no information on the impact of unfavorable factors of the tobacco-growing industry on the organs and tissues of the oral cavity of workers and the corresponding therapeutic and prophylactic measures, with the exception of individual works [7,2] in the form of an article, where long-term exposure to tobacco extract under experimental conditions, combined with a single dose and a population herpes simplex virus, cause clinical and morphological changes resembling leukoplakia.
Learning Bioavailability Of “Diabderm” Ointment With Method Of “In Vitro”
Authors:   Department Of Industrial Technology Of Medicines, Tashkent Pharmaceutical Institute, Tashkent, Uzbekistan, Shukhratovna Khusenova Shakhnoza , Sultanovna Fayzullaeva Nodira ,   Department Of Industrial Technology Of Medicines, Tashkent Pharmaceutical Institute, Tashkent, Uzbekistan
Published: May 2021

In diabetes mellitus, a small focus of infection causes significant gangrene of the foot due to thrombosis of the peripheral and central vessels of the fingers. In 35–40% of patients with diabetes mellitus, isolated gangrene of several fingers is noted, and in 20–25% - only one finger. Gangrene of the foot can be dry or with a predominance of anaerobic-non-clostridial infection. Some patients have necrosis or gangrene of certain areas of the skin of the foot or lower leg. The main goal of diabetic gangrene treatment is to keep the areas of wet skin necrosis dry.
Efficiency Of Intra-Articular Administration In Early Osteoarthrosis
Authors:   Samarkand State Medical Institute Of The Ministry Of Health Of The Republic Of Uzbekistan, K. A . Islamova , F. Sh Khasanov ,   Samarkand State Medical Institute Of The Ministry Of Health Of The Republic Of Uzbekistan, E. S. Toirov ,   Samarkand State Medical Institute Of The Ministry Of Health Of The Republic Of Uzbekistan
Published: May 2021

The purpose of this study was to investigate the function of knee joints in patients with early osteoarthritis (OA, according to the criteria of the American rheumatology Association 2010) stage I-III using visual analogue scale (VAS) for pain intensity and treatment outcomes, Lequesne index, expert indicators, samples of 4 meter walk to assess the effectiveness of intra-articular injection Hyaluronic Chondro. 80 patients aged 28 to 55 years were examined. The treatment regimen included recommendations from the European rheumatology League (EULAR, 2016) and Russia (Nasonov E. L., 2017). The results of therapy were evaluated in two groups. The first group included 43 patients who received Hyaluronic Chondro in the form of intra-articular injections, the second-37 patients who received chondroprotectors inside or in the form of intramuscular injections. Conclusion. Intra-articular administration of the drug Chondrogard has a positive clinical effect in early stage II-III OA with moderate impairment of knee joint function. The course of treatment should last at least 2 months
Results Of Treatment Of Acute Diffuse Purulent Peritonitis Using Laparostomy
Authors:   Samarkand State Medical Institute, Samarkand Branch Of The Republican Scientific Center For Emergency Medical Care. Uzbekistan, Ruziboev S. A. , Avazov A. A. ,   Samarkand State Medical Institute, Samarkand Branch Of The Republican Scientific Center For Emergency Medical Care. Uzbekistan, Sattarov Sh. Kh. ,   Samarkand State Medical Institute, Samarkand Branch Of The Republican Scientific Center For Emergency Medical Care. Uzbekistan, Elmuradov A. N. ,   Samarkand State Medical Institute, Samarkand Branch Of The Republican Scientific Center For Emergency Medical Care. Uzbekistan
Published: May 2021

Currently, despite significant achievements in the field of surgery, anesthesiology and resuscitation, the results of treatment of patients with advanced purulent peritonitis remain one of the most intractable problems, almost every sixth patient with acute surgical diseases and injuries of the abdominal cavity is admitted to medical institutions with peritonitis [1,3] Common peritonitis in 17-29% complicates the course of most acute surgical diseases and is the main cause of deaths in surgical hospitals [3,7]. Lethality in advanced peritonitis remains extremely high and reaches 20-39% [1,2,4,5]. In recent decades, great importance has been attached to recording intra-abdominal pressure in purulent pathology of the abdominal cavity. It was found that intra-abdominal hypertension occurs in every third patient with acute surgical pathology and negatively affects the functioning of all organs and systems of the body [1,6,8]. Pathological changes that occur with acute and excessive increase in intra-abdominal pressure (IAP) are manifestations of abdominal compartment syndrome (ACS) with disorders of the cardiovascular system; urinary disorders, disorders of perfusion of internal organs and the development of intestinal ischemia, which contributes to bacterial translocation and endogenous infection [2,7,8]. Ischemic blood flow disorders of the splanchnic zone are fraught with the development of bacterial translocation and the development of systemic inflammatory response syndrome and multiple organ failure (PON). Unsatisfactoriness with such results gave rise to a fundamentally different approach to the surgical treatment of common forms of peritonitis-the introduction of an open abdominal management method based on the ideas of I. Mikulich (1881), Jean-Louis Faure (1928), N. S. Makoch (1984) and D. Steinberg (1979).
Neuroses And The Factors Which Contribute To It
Authors:   Samarkand State Medical Institute Assistant Of The Department Of Pediatric Dentistry, Samarkand Region, Uzbekistan, Shuxratovich Shukurov Sherzod , Musurmonovich Abdisayitov Shaxzod ,   Samarkand State Medical Institute Clinical Resident Of The Department Of Pediatric Dentistry, Samarkand Region, Uzbekistan, Shodiyorovich Norbekov Laziz ,   Samarkand State Medical Institute Clinical Resident Of The Department Of Pediatric Dentistry, Samarkand Region, Uzbekistan
Published: May 2021

Neuroses are psychogenic disorders that develop as a result of long-term exposure to a traumatic event with low intensity and sharpness. In these cases, there is usually talked of disagreements in the family, production, and work community, which are not even perceived by the patient as a factor of emotional trauma. The depth of mental disorders is relatively low in neuroses - there are no deep disturbances of thinking, cognition and consciousness, and a critical attitude to others and one's own state is preserved. The article looks into the neurosis and its causes and correlation with other illnesses.
Clinical And Functional Changes In Hard Tissues Of Teeth In Patients With Hemophilia
Authors:   Samarkand State Medical Institute, Uzbekistan, Norbutaev Alisher Berdikulovich , Shamsiev Mukhiddin Kamariddinovich ,   Samarkand State Medical Institute, Uzbekistan, Nazarova Nodira Sharipovna ,   Samarkand State Medical Institute, Uzbekistan
Published: May 2021

Hereditary coagulopathies characterized by reduced blood clotting occupy a special place among diseases of the blood system. The most common of these are hemophilia and Willebrand's disease. Hemophilia-the disease of "royals" - is an old, but still relevant disease. Hereditary coagulopathies, characterized by reduced blood clotting, occupy a special place among diseases of the blood system. Based on who data and the likely frequency of research on these diseases, the prevalence of hemophilia ranges from 3 to 25 patients per 10,000 population. Few studies of the oral cavity in patients with hemophilia have shown a high level of dental diseases, poor hygiene of the oral cavity. This is due to the lack of proper oral care, and dispensary monitoring, fear of prolonged bleeding after dental manipulations. For this reason, dentists try to avoid treating dental diseases in this category of patients. At the same time, modern achievements of medical science in the field of Hematology and the development of effective replacement therapy allow to prevent almost all types of bleeding. However, this group of patients is still unable to receive timely and high-quality dental treatment and prevention, which largely determines the high prevalence of inflammatory diseases of the maxillofacial region. All of the above is evidence of the presence of many predisposing factors of damage to the dental system in patients with hemophilia, as well as the need for preventive, therapeutic, including orthopedic dental measures for this category of patients.
Ways To Improve The Organization Of Dental Services For Chemical Industry Workers
Authors:   Professor, Rector Of The Samarkand State Medical Institute, Uzbekistan, Rizaev Zhasur Alimdzhanovich , Abdunosirovich Rahimberdiev Rustam ,   Head Of The Department Of Pediatric Dentistry Of The Samarkand State Medical Institute, Uzbekistan, Sharipovna Nazarova Nodira ,   PhD, Associate Professor Of The Department Of Dentistry, Faculty Of Postgraduate Education, Uzbekistan
Published: May 2021

In recent years, research has been carried out to study the problems of improving the organization of dental care for both the General population and individual categories of industrial workers4,6. However, to date not carried out in-depth studies on the problems of improvement of dental care to employees of the chemical industry in the new socio-economic conditions of development of industrial complex and reform of the health system, there is no comprehensive study of the current status of dental service medical-sanitary unit (MSCH) large enterprises, comparison of availability and quality of dental care to employees at the place of residence and place of work. The purpose of this review is to study the dental morbidity of chemical workers, develop measures to improve their dental health and improve the quality of life. At the present stage of development of the industrial complex of our country, a number of large enterprises have the opportunity to organize dental care for employees, primarily with harmful working conditions, at a higher level. At the same time, the implementation of the preventive orientation in dental care for the working population remains an unsolved problem2,3. The successful functioning of any medical service in modern conditions is possible only with the optimal interaction of all parts, all elements of the health system depends largely on the level of organization and management of medical institutions to optimize their work7,8. Keywords: Condition of the mucous membrane of the oral cavity, the hard tissues of teeth and paradontium, taste analyzer, unfavorable factors of production. Material And Methods Of Research: It is planned to conduct a study of 120 workers of JSC "samarkandkime" - the main group, as well as 115 patients who applied to polyclinic No. 10 and are not related to the chemical industry - the control group. The data that was received was subjected to statistical processing using the Microsoft Excel application package. The reliability of the difference in parameters was determined by the student's criterion. Results and discussion.Currently, the issues of dental health for workers in various industries are relevant. Various harmful factors of production can have a negative impact on human health, including on the tissues of the teeth, periodontal, oral and lip mucosa.
Monitoring And Evaluation Of Hemodynamic Parameters During Anesthesia In Endocrine Surgery
Authors:   Assistant Professor Of Anesthesiology And Critical Care Medicine, Samarkand State Medical Institute, Uzbekistan, Shuxratovich Joniev Sanjar , Kuylievich Shukur Pardaev ,   Associate Professor Of Anesthesiology And Critical Care Medicine, Samarkand State Medical Institute, Uzbekistan, Raxmonovich Akramov Bahodir ,   Assistant Of The Department Of Anesthesiology And Resuscitation Of The Samarkand State Medical Institute, Uzbekistan, Oftedal Ugli Hushvakov Ulmas ,   Assistant Professor Of Anesthesiology And Critical Care Medicine, Samarkand State Medical Institute, Uzbekistan
Published: May 2021

The article presents the results of preoperative preparation, anesthesia and surgical treatment of patients operated on for non-toxic nodular goiter. A new approach to preoperative preparation for thyroid surgery is described. The effectiveness in the preoperative period of using the modified method of preoperative preparation using sibazon and droperidol and anesthesia with the use of ketamine and the advantages of this method compared with other methods of general anesthesia are shown.
Meaning Of Respiratory Mycoplasma Infection In Children With Bronchial Asthma
Authors:   Doctor Of Medical Sciences, Associate Professor, Department Of Children`S Diseases №1, Medical Faculty, Tashkent Medical Academy, Uzbekistan, Toshmatova Gulnoza Aloevna , Shakarova Maftuna Shukhrat Qizi ,   Master Student Of 3rd Year, Department Of Children`S Diseases №2, Medical Faculty, Tashkent Medical Academy, Uzbekistan
Published: May 2021

Meaning and role of mycoplasma infection for children with bronchial asthma small studied. By us was inspected 39 children with BA in age from 2 to 14, from them 27 (69,2%) boys and 12 (30,8) girls. Obtained data from PChR testing is shown: among the children of patients with BA for 33,3% (13/39) patients found out M. pneumoniae.; for 66,7% (26/39) patients and for all children of control group M. pneumoniae. it is not discovered (table.№1). For children in a range 2-5, the more than half (53,8%) of children-asthmatics was got positive results of PChR; among the investigated children in age 6-14, only at 46,2% patients had M. pneumonia. Except it, among patients with BA, for 69,2% boys and 31% girls made the positive result of PChR, and correlation of sexes was made by 2,2: 1.
Method For Determining The Content Of Toxic Substances In The Liver After Exposure To Pesticides In Experimental Animals
Authors:   Candidate Of Medical Sciences, Associate Professor Of The Department Of General Surgery Fergana Medical Institute Of Public Health, Uzbekistan, Turginbaevich Mamasaidov Jamolidin
Published: May 2021

This scientific work is devoted to the study of the results of the action of pesticides on the organism of experimental animals. At the beginning, a brief review of the literature devoted to this problem is given. The author also describes a method for determining the content of toxic substances in the liver tissues of experimental animals. The corresponding conclusions on the simplicity of the method are made.
Medical Problems In Patients With Alcohol Dependence With Common Schizophrenia And Schizoaffective Disorder
Authors:   Bukhara Medical Institute, Uzbekistan, Karimova S.Sh. , Ergasheva Yu.Y. ,   Bukhara Medical Institute, Uzbekistan
Published: May 2021

Goal of this study of the relationship between alcohol use, severity of psychiatric symptoms and the number of verified medical diagnoses. The study was that self-reporting of medical history is less accurate in patients with comorbid alcohol dependence and schizophrenia compared with patients with alcohol dependence only or with control. 46 patients with schizophrenia or schizoaffective disorder and concomitant alcohol dependence recruited from the Bukhara Regional Psychoneurological Dispensary. 27 patients suffered from schizophrenia, and 19 patients from schizoaffective disorder.
The Effect Of Arni On The Functional State Of The Kidneys In Patients With IHD
Authors:   Department Of Faculty Internal Diseases, Occupatuonal Pathology, MFT, Hospital Internal Diseases And PID, Tashkent Pediatric Medical Institute, Tashkent, Republic Of Uzbekistan, Muminov Shavkat Kadirovich
Published: May 2021

Purpose of the study: сomparative study of the effect of ARNI (combination of valsartan and sacubitrile) on the structural and functional state of the kidneys in patients with IHD after revascularization. Material and research methods. The study included 320 patients with coronary artery disease. 37 patients underwent surgical revascularization (CABG), 283 patients underwent endovascular revascularization. On average, the concentration of creatinine was 90.08 ± 1.72 µmol /l. All patients were divided into 2 groups: patients who received the drug valsartan (group B, 160 people), patients who received a combination of valsartan and sacubitril a (ARNI - a combination of a molecule of valsartan and an inhibitor of neprilysin sacubitril in a molar ratio of 1: 1) (group C, 160 people). Also, all patients were divided into 2 subgroups depending on the degree of eGFR decrease by the 3rd month of observation: patients with a decrease in eGFR by the 3rd month of observation more than 20% (group 1 - 59 patients) and less than 20% (group 2 - 261 sick). In dynamics, three months later, at the end of the first and second years of follow-up after revascularization, the patients underwent determination of the blood creatinine concentration, with the calculation of GFR and ultrasound examination (US) of the kidneys with dopplerography of the segmental arteries. Research results. The study showed that during 2 years of follow-up after coronary revascularization, there was a decrease in eGFR in both groups of patients, regardless of the therapy. Comparative analysis of the dynamics of eGFR between patients with different treatment regimens, depending on the severity of the decrease in eGFR, showed that the dynamics of the progression of CKD was significantly greater in patients with decreased eGFR by the 3rd month of therapy by 20% or more compared with patients who received sacubitril in the therapy regimen.The difference becomes significant only by the 1st year of observation and persists by the 2nd year of observation. Resistivity index of renal segmental arteries by the end of observation in-group C was significantly (p <0.05) lower than in-group B. Conclusion. The inclusion of ARNI (a combination of valsartan and sacubitril) in the IHD treatment regimen contributes to a significant decrease in the rate of progression of CKD in patients prone to rapid progression of type II cardiorenal syndrome. Against the background of ARNI application, there was a tendency to slow down the progression of pathological renal glomerular vascular remodeling.
Improving The Principles Of Treatment In Patients With Zoonotic Leishmaniasis With The Immunomodulator Gepon And Methylene Blue Using The Alt Vostok Apparatus
Authors:   Bukhara State Medical Institute, Uzbekistan, Bobomurodovich Rakhmatov Olim , Farkhodovna Khushvaktova Madina ,   Bukhara State Medical Institute, Uzbekistan
Published: May 2021

The object of the study was 102 patients with zoonotic leishmaniasis aged 2 to 65 years. The diagnosis of zoonotic leishmaniasis was established by clinical and epidemiological data and confirmed by the results of parasitological studies. We studied the duration of the clinical periods of zoonotic leishmaniasis against the background of complex therapy with methylene blue using the ALT Vostok apparatus in the control group of 51 patients and complex therapy with methylene blue using the ALT Vostok apparatus and the immunomodulator Gepon in the main group of 51 patients. The results of the study showed that in patients of the main group, on the background of treatment with the ALT Vostok apparatus using the immunomodulator Gepon, the duration of the main periods was significantly reduced than in the control group, who were treated only with methylene blue using the ALT Vostok model-03 apparatus.
Clinical And Morphological Features And Histological Variants Of Borderline Types Of Ovarian Tumors
Authors:   Department Of Oncology And Radiology, Andijan State Medical Institute, Andijan, Uzbekistan, Sadiqovna Yakubbekova Sokhibakhon , Israilovich Israilov Rejab ,   Doctor Of Medicine, Professor, Director Of The Republican Pathological Center, Tashkent, Uzbekistan, Zakirjanovna Mamarasulova Dilfuzaxon ,   Doctor Of Medicine, Docent, Department Of Oncology And Radiology, Andijan State Medical Institute, Andijan, Uzbekistan, Daliyevich Azizov Yuriy ,   Doctor Of Medicine, Andijan State Medical Institute, Andijan, Uzbekistan, Tahirovna Inaqova Zebo ,   Student, Andijan State Medical Institute, Andijan, Uzbekistan
Published: May 2021

According to modern scientific literature, among all ovarian tumors, the borderline type occurs from 5 to 15%. This study analyzed the clinical and morphological features and histological variants of borderline types of ovarian tumors. The results of the study showed that among the borderline type of ovarian tumors, serous (46.8%) and mucinous types (42.7%) are more common, while other types, such as endometrioid, mesonephroid, Brenner, and mixed variants make up a low percentage. It was found that serous cystic tumors, in most cases bilateral, common cyst, cystadenoma, papillary adenoma histologically consists of two epithelia, that is, from the mesothelium and secretory cells, it is confirmed that with malignancy, elongated and basaloid cells are metaplastic. It was observed that mucinous borderline tumors were mainly found on one side, disabled adenofibroma, cystoadenomas were filled with mucous contents, monolayer epithelium was metoplasized with stratified epithelium. Among the rare borderline tumors, the endometrioid type, Brenner, mesonephriodal and mixed type were identified.
The Effect Of Uric Acid Metabolism Disorders On The Cardiovascular System In Children With Pyelonephritis
Authors:   Assistant At The Department Of Pediatric Propaedeutics, Pediatrics And Higher Nursing, Urgench Branch Of TTA, Uzbekistan, N.T. Rajabova , Z.A. Ismailova ,   Assistant At The Department Of Pediatric Propaedeutics, Pediatrics And Higher Nursing, Urgench Branch Of TTA, Uzbekistan, T.A. Klicheva ,   Assistant At The Department Of Pediatric Propaedeutics, Pediatrics And Higher Nursing, Urgench Branch Of TTA, Uzbekistan
Published: May 2021

Both nephrologists [Vasilyeva M.P. et al., 2015; Mukhin N.A. et al., 2015], and cardiologists [Кuo-ChengLue.a.,2014 ] recognized the fact that most of the currently known risk factors for cardiovascular disease (hypertension, obesity, diabetes mellitus, dyslipoproteinemia, microalbuminuria, etc.) are also risk factors for chronic kidney disease (ChKD). An inverse relationship, i.e. the influence of renal pathology on the frequency of cardiovascular disease detection has been established [Galushkin A.A. et al., 2013]. This fact is especially relevant in disorders of uric acid (UA) metabolism, as the recent literature data indicate a significant role of UA in the development of cardiovascular diseases. However, these issues are intensively studied in therapeutic practice, but they are certainly relevant for pediatric practice [M.S.Ignatova, 2011; VyalkovaA.A.,2012].
Rational Use Of Drugs In The Comprehensive Treatment Of Bronchoobstructive Syndrome In Children
Authors:   Assistant Department of ", Z.A., Ismoilova ,   PChD, Pediatrics and HN",   of Urgench branch of TMA, Uzbekistan, N. T Rajabova ,   Assistant Department of "PChD, Pediatrics and HN" of Urgench branch of TMA, Uzbekistan, N. N. Ishankulova ,   Department of Internal Medicine 1, Senior Lecturer Samarkand State Medical Institute, Uzbekistan
Published: May 2021

Treatment of bronchoobstructive syndrome in children and integrated use of drugs, that is, each drug should be pathogenetically justified, taking into account the individual characteristics of the child, and based on knowledge of the mechanism of their action and pharmacokinetics. It is necessary to have a complex effect on individual links of the pathogenesis of bronchoobstructive syndrome in many cases makes the use of complex drugs with combined mechanism of action justified. Thus, treatment of bronchoobstructive syndrome in children before a pediatrician is a responsible task, which consists in rational selection of medicines.
The Prevalence Of Metabolic Syndrome In Older People: “Attitude Towards Population Success”
Authors:   Andijan State Medical Institute, Uzbekistan, N.S. Mamasoliev , Kh.Kh. Tursunov ,   Bukhara State Medical Institute, Uzbekistan, G.Kh. Rajabova ,   Bukhara State Medical Institute, Uzbekistan
Published: May 2021

The problem of various components of MS is at the center of attention of modern medical science and healthcare. Kazno Toushita reports (2018) that in Japan, almost half of Japanese men and a quarter of Japanese women are either visceral obesity or overweight, and that the number of such patients increases with age. There fore, a special prevention program was launched in 2008, and now medical insurance companies must provide annual check-ups for all people between the ages of 40 and 75.
Diagnosisand Therapy Of Pancreatic Dysfunction In Atopic Dermatitis In Children
Authors:   Professor, Head Of The Department Of Children's Diseases №1, Tashkent Medical Academy, Tashkent, Uzbekistan, Barnoturdixodjayevna Khalmatova , Khabibullayevna Mirrakhimova Maktuba ,   Docent,Dsc, Department Of Children's Diseases №1, Tashkent Medical Academy, Tashkent, Uzbekistan, Yunusjanovna Nishonboyeva Nilufar ,   Assistant, First Faculty Of Children’s Diseases, Tashkent Medical Academy, Tashkent, Uzbekistan
Published: May 2021

Most of allergic diseases are caused by allergic skin lesions.The aim of the study was to assess the effectiveness of the enzyme agents in the correction of pancreatic insufficiency in children with atopic dermatitis.As a result of the study clinical and laboratory markers of relative pancreatic insufficiency were identified in 69.7% of the patients, who required the prescription of enzyme agents. The results also showed that in 92.5% of patients the correction of exocrine function disorders to a certain extent affects the regression of dermal manifestations. In the scatological tests the loss of neutral fat, normalization of the amount of elastase in feces serve to be a marker of the effectiveness of the enzymatic therapy.
The Role Of Laboreatory Biomarkers In The Diagnosis Of Early Cartilage Destruction In Reactive Arthritis
Authors:   Tashkent Medical Academy, Uzbekistan, F.I. Khalmetova , K.S. Akhmedov ,   Tashkent Medical Academy, Uzbekistan
Published: May 2021

Reactive arthritis is an inflammatory lesion of the joints that occurs as a reaction to the invasion of the body by any infectious agents. The high social significance of nosologies dictates the need to search for reliable cartilage biomarkers that have diagnostic value not only in recognizing degenerative changes at an early stage of joint deseases, but also in monitoring the effectiveness of treatment.
Implementation Of Distance Technologies In The System Of Advancing The Personnel Of The Pre-School Education System Of The Republic Of Uzbekistan
Authors:   Doctor Of Philosophy (PhD) In Economic Sciences, Rector Of The Institute For Retraining And Advanced Training Of Directors And Specialists Of Preschool Educational Organizations, Tashkent, Uzbekistan, Eshpulatov Komiljon Abdusalomovich , Abdunazarova Nargiza Fatkhullaevna ,   Candidate Of Pedagogy, Associate Professor, Vice-Rector Of The Institute For Retraining And Advanced Training Of Directors And Specialists Of Preschool Educational Organizations, Tashkent, Uzbekistan
Published: May 2021

This article describes the essence of distance learning technologies in the system of professional development of preschool education and its implementation in practice.
Theoretical Basis For Modernization Of Higher Education
Authors:   Teacher Of Namangan Institute Of Engineering Technology, Namangan City, Uzbekistan, Jumanazarova Zuhra Qosimjonovna
Published: May 2021

The article reveals issues such as the modernization of higher education, its content, different approaches, the theoretical foundations of the importance of the process of modernization in higher education.
Increasing The Level Of Professional Skills Of A Teacher As A Condition Of Transition To Innovative Pedagogical Activities
Authors:   Doctor Of Philosophy (PhD) In Pedagogy Independent Researcher Of The Institute Of Pedagogical Innovations, Vocational Education Management And Retraining And Advanced Training Of Teachers, Tashkent, Uzbekistan, Mirzaeva Feruza
Published: May 2021

The article covers issues such as the level of professional development of teachers, the conditions for the transition to innovative pedagogical activity, innovative activity and its content.
Interaction Of The School With The Mahalla Committee In The Process Of Spiritual Education
Authors:   Assistant, Karshi State University Karshi city, Uzbekistan., Kurbanova Aziza Uktamovna
Published: May 2021

This article describes the role of the mahalla in public life, the interaction of the mahalla with schools in spiritual and moral education, the role of the family in the mahalla.
Factors Of E’rab And Their Types In Arabic Grammar
Authors:   Associate Professor Of The Department Of Arabic Philology, Tashkent State University Of Oriental Studies, Uzbekistan, Begmatova Buzahro Marufjanovna
Published: May 2021

In Arabic, there are a number of factors that cause nouns and verbs to be varied and confused and they have been called “Factors of E'rab”. This article discusses the factors of E’rab and their types of Arabic Grammar.
National Holidays Of The Korean People
Authors:   The Head Teacher Of History In Academic Lyceum Of Fergana State University, Uzbekistan, Usarkulov Oybek , Tursunoy Abduvalieva ,   Student Foreign Language And Literature Ferghana State University, Uzbekistan
Published: May 2021

This article reflects the national holidays of the Korean people, which have a spiritual and educational significance, reflecting the national identity.
Women’s Problem At A New Stage Of Socio-Economic And Political Change In Uzbekistan: Problems And Solutions
Authors:   Senior Teacher Of The National University Of Uzbekistan Named After Mirzo Ulugbek, Doctor Of Philosophy (PhD) In History, Uzbekistan, Baltabaeva Manzurakhon Mirzajanovna
Published: May 2021

The article analyzes the issue of women in the new stage of socio-economic and political changes in Uzbekistan: problems and solutions, ensuring gender equality, career guidance for women with the help of scientific sources and periodicals.
Sporting Activity Is The Main Means Of Children's Health
Authors:   Associate Professor, Jizzakh State Pedagogical Institute, Uzbekistan, Mukimov Olimjon Ergashevich , Turgunov Bakhtiyor Urolovich ,   Senior Lecturer, Jizzakh State Pedagogical Institute, Uzbekistan
Published: May 2021

This article provides a theoretical analysis of the role and place of sports in strengthening children's health, as well as the involvement of children in sports and sports activities with children.
The Legal Basis Of The Organization Of Educational Process In Military Educatinoal Institutions
Authors:   Professor Of The Department Of Pedagogy And Psychology Of Military-Technical Institute Of The National Guard Of The Republic Of Uzbekistan, Doctor Of Pedagogical Sciences, Tashkent, Uzbekistan, Makhmudov Ruzmet Muratovich , Khodiev Rustamjon Khamdamovich ,   Independent Researcher Of Military-Technical Institute Of The National Guard Of The Republic Of Uzbekistan, Tashkent, Uzbekistan
Published: May 2021

The article describes the main legal documents regulating the sphere of military education. The features improving the system of highly-qualified personnel preparation of high adequate are studied. The article also indicates achievements in the field of military security, dynamic changes in the state, issues of training professional military personnel, as well as tasks that should be implemented in improving the legal framework and mechanisms of military education of the Republic of Uzbekistan, the procedure for admission to higher educational institutions of citizens undergoing military service in the Armed Forces of the Republic of Uzbekistan, as well as the benefits provided to them.
The Participation Of Andizhan Warriors In Liberation Of European Peoples From Fascism
Authors:   Andizhan State University, Associate Professor Of World History, Candidate Of Historical Sciences (Phd), Andizhan Region, Republic Of Uzbekistan, Mamajonov Alisher
Published: May 2021

The article describes the World War II as a catastrophe of fascism, the participation of Andizhan fighters in the liberation of European peoples in the fight against it, as well as their active courage in the fierce battles, based on sources in the regional archives.
Common errors in filling in spreadsheets and how to avoid them
Authors: Lysenkov S. N.
Published: May 2021

Errors during research can occur not only at the stage of planning, data collection and statistical analysis, but also at the stage of ﬁlling in spreadsheets. In most cases they can be easily corrected, otherwise results may be distorted. These errors can be categorized into invalid format and input errors. In the ﬁrst case, the mixing of the absence of data and the zero values is especially dangerous, since it can lead to systematic errors: overestimation (if the zero values are ﬁlled in as the absence of data) or underestimation (if the absence of data is ﬁlled in as zero values) of the mean or the prevalence. Input errors are most often random, and their effect decreases with increasing sample size, but for the better analysis they should also be corrected as much as possible. The article provides an algorithm that allows you to ﬁnd input errors and correct them before statistical analysis.