bluuebunny/crossref_metadata_2025 huggingface dataset:
Climate Change Impacts on Salt Marsh Blue Carbon, Nitrogen and Phosphorous Stocks and Ecosystem Services
Authors: Duarte Bernardo , Carreiras João , Caçador Isabel
Published: February 2021

Salt marshes are valuable ecosystems, as they provide food, shelter, and important nursery areas for fish and macroinvertebrates, and a wide variety of ecosystem services for human populations. These ecosystem services heavily rely on the floristic composition of the salt marshes with different species conferring different service values and different adaptation and resilience capacities towards ecosystem stressors. Blue carbon, nitrogen, and phosphorous stocks are no exception to this, and rely on the interspecific differences in the primary production metabolism and physiological traits. Furthermore, these intrinsic physiological characteristics also modulate the species response to any environmental stressor, such as the ones derived from ongoing global changes. This will heavily shape transitional ecosystem services, with significant changes of the ecosystem value of the salt marshes in terms of cultural, provisioning, regulating, and supporting ecosystem services, with a special emphasis on the possible alterations of the blue carbon, nitrogen, and phosphorous stocks retained in these key environments. Thus, the need to integrate plant physiological characteristics and feedbacks towards the expected climate change-driven stressors becomes evident to accurately estimate the ecosystem services of the salt marsh community, and transfer these fundamental services into economic assets, for a fluid communication of the ecosystems value to stakeholders, decision and policy makers, and environmental management entities.
Anti-TNF Alpha Antibody Humira with pH-dependent Binding Characteristics: A constant-pH Molecular Dynamics, Gaussian Accelerated Molecular Dynamics, and In Vitro Study
Authors: Hong Shih-Ting , Su Yu-Cheng , Wang Yu-Jen , Cheng Tian-Lu , Wang Yeng-Tseng
Published: February 2021

Humira is a monoclonal antibody that binds to TNF alpha, inactivates TNF alpha receptors, and inhibits inflammation. Neonatal Fc receptors can mediate the transcytosis of Humira–TNF alpha complex structures and process them toward degradation pathways, which reduces the therapeutic effect of Humira. Allowing the Humira–TNF alpha complex structures to dissociate to Humira and soluble TNF alpha in the early endosome to enable Humira recycling is crucial. We used the cytoplasmic pH (7.4), the early endosomal pH (6.0), and pKa of histidine side chains (6.0–6.4) to mutate the residues of complementarity-determining regions with histidine. Our engineered Humira (W1-Humira) can bind to TNF alpha in plasma at neutral pH and dissociate from the TNF alpha in the endosome at acidic pH. We used the constant-pH molecular dynamics, Gaussian accelerated molecular dynamics, two-dimensional potential mean force profiles, and in vitro methods to investigate the characteristics of W1-Humira. Our results revealed that the proposed Humira can bind TNF alpha with pH-dependent affinity in vitro. The W1-Humira was weaker than wild-type Humira at neutral pH in vitro, and our prediction results were close to the in vitro results. Furthermore, our approach displayed a high accuracy in antibody pH-dependent binding characteristics prediction, which may facilitate antibody drug design. Advancements in computational methods and computing power may further aid in addressing the challenges in antibody drug design.
Nervous Activity of the Brain in Five Dimensions
Authors: Tozzi Arturo , Peters James F. , Jausovec Norbert , Don Arjuna P. H. , Ramanna Sheela , Legchenkova Irina , Bormashenko Edward
Published: February 2021

The nervous activity of the brain takes place in higher-dimensional functional spaces. It has been proposed that the brain might be equipped with phase spaces characterized by four spatial dimensions plus time, instead of the classical three plus time. This suggests that global visualization methods for exploiting four-dimensional maps of three-dimensional experimental data sets might be used in neuroscience. We asked whether it is feasible to describe the four-dimensional trajectories (plus time) of two-dimensional (plus time) electroencephalographic traces (EEG). We made use of quaternion orthographic projections to map to the surface of four-dimensional hyperspheres EEG signal patches treated with Fourier analysis. Once achieved the proper quaternion maps, we show that this multi-dimensional procedure brings undoubted benefits. The treatment of EEG traces with Fourier analysis allows the investigation the scale-free activity of the brain in terms of trajectories on hyperspheres and quaternionic networks. Repetitive spatial and temporal patterns undetectable in three dimensions (plus time) are easily enlightened in four dimensions (plus time). Further, a quaternionic approach makes it feasible to identify spatially far apart and temporally distant periodic trajectories with the same features, such as, e.g., the same oscillatory frequency or amplitude. This leads to an incisive operational assessment of global or broken symmetries, domains of attraction inside three-dimensional projections and matching descriptions between the apparently random paths hidden in the very structure of nervous fractal signals.
Recent Applications of Heteropolyacids and Related Compounds in Heterocycle Synthesis. Contributions between 2010 and 2020
Authors: Escobar Angélica M. , Blustein Guillermo , Luque Rafael , Romanelli Gustavo P.
Published: February 2021

Over the past two decades, polyoxometalates (POM) have received considerable attention as solid catalysts, due to their unique physicochemical characteristics, since, first, they have very strong Bronsted acidity, approaching the region of a superacid, and second, they are efficient oxidizers that exhibit rapid redox transformations under fairly mild conditions. Their structural mobility is also highlighted, since they are complex molecules that can be modified by changing their structure or the elements that compose them to model their size, charge density, redox potentials, acidity, and solubility. Finally, they can be used in substoichiometric amounts and reused without an appreciable loss of catalytic activity, all of which postulate them as versatile, economic and ecological catalysts. Therefore, in 2009, we wrote a review article highlighting the great variety of organic reactions, mainly in the area of the synthesis of bioactive heterocycles in which they can be used, and this new review completes that article with the contributions made in the same area for the period 2010 to 2020. The synthesized heterocycles to be covered include pyrimidines, pyridines, pyrroles, indoles, chromenes, xanthenes, pyrans, azlactones, azoles, diazines, azepines, flavones, and formylchromones, among others.
Valorization of Raw and Calcined Chicken Eggshell for Sulfur Dioxide and Hydrogen Sulfide Removal at Low Temperature
Authors: Ahmad Waseem , Sethupathi Sumathi , Munusamy Yamuna , Kanthasamy Ramesh
Published: February 2021

Chicken eggshell (ES) is a waste from the food industry with a high calcium content produced in substantial quantity with very limited recycling. In this study, eco-friendly sorbents from raw ES and calcined ES were tested for sulfur dioxide (SO2) and hydrogen sulfide (H2S) removal. The raw ES was tested for SO2 and H2S adsorption at different particle size, with and without the ES membrane layer. Raw ES was then subjected to calcination at different temperatures (800 °C to 1100 °C) to produce calcium oxide. The effect of relative humidity and reaction temperature of the gases was also tested for raw and calcined ES. Characterization of the raw, calcinated and spent sorbents confirmed that calcined eggshell CES (900 °C) showed the best adsorption capacity for both SO2 (3.53 mg/g) and H2S (2.62 mg/g) gas. Moreover, in the presence of 40% of relative humidity in the inlet gas, the adsorption capacity of SO2 and H2S gases improved greatly to about 11.68 mg/g and 7.96 mg/g respectively. Characterization of the raw and spent sorbents confirmed that chemisorption plays an important role in the adsorption process for both pollutants. The results indicated that CES can be used as an alternative sorbent for SO2 and H2S removal.
HIV-1 Latency and Viral Reservoirs: Existing Reversal Approaches and Potential Technologies, Targets, and Pathways Involved in HIV Latency Studies
Authors: Khanal Sushant , Schank Madison , El Gazzar Mohamed , Moorman Jonathan P. , Yao Zhi Q.
Published: February 2021

Eradication of latent human immunodeficiency virus (HIV) infection is a global health challenge. Reactivation of HIV latency and killing of virus-infected cells, the so-called “kick and kill” or “shock and kill” approaches, are a popular strategy for HIV cure. While antiretroviral therapy (ART) halts HIV replication by targeting multiple steps in the HIV life cycle, including viral entry, integration, replication, and production, it cannot get rid of the occult provirus incorporated into the host-cell genome. These latent proviruses are replication-competent and can rebound in cases of ART interruption or cessation. In general, a very small population of cells harbor provirus, serve as reservoirs in ART-controlled HIV subjects, and are capable of expressing little to no HIV RNA or proteins. Beyond the canonical resting memory CD4+ T cells, HIV reservoirs also exist within tissue macrophages, myeloid cells, brain microglial cells, gut epithelial cells, and hematopoietic stem cells (HSCs). Despite a lack of active viral production, latently HIV-infected subjects continue to exhibit aberrant cellular signaling and metabolic dysfunction, leading to minor to major cellular and systemic complications or comorbidities. These include genomic DNA damage; telomere attrition; mitochondrial dysfunction; premature aging; and lymphocytic, cardiac, renal, hepatic, or pulmonary dysfunctions. Therefore, the arcane machineries involved in HIV latency and its reversal warrant further studies to identify the cryptic mechanisms of HIV reservoir formation and clearance. In this review, we discuss several molecules and signaling pathways, some of which have dual roles in maintaining or reversing HIV latency and reservoirs, and describe some evolving strategies and possible approaches to eliminate viral reservoirs and, ultimately, cure/eradicate HIV infection.
Sensitivity of Simulations of Zambian Heavy Rainfall Events to the Atmospheric Boundary Layer Schemes
Authors: Bopape Mary-Jane M. , Waitolo David , Plant Robert S. , Phaduli Elelwani , Nkonde Edson , Simfukwe Henry , Mkandawire Stein , Rakate Edward , Maisha Robert
Published: February 2021

Weather forecasting relies on the use of numerical weather prediction (NWP) models, whose resolution is informed by the available computational resources. The models resolve large scale processes, while subgrid processes are parametrized. One of the processes that is parametrized is turbulence which is represented in planetary boundary layer (PBL) schemes. In this study, we evaluate the sensitivity of heavy rainfall events over Zambia to four different PBL schemes in the Weather Research and Forecasting (WRF) model using a parent domain with a 9 km grid length and a 3 km grid spacing child domain. The four PBL schemes are the Yonsei University (YSU), nonlocal first-order medium-range forecasting (MRF), University of Washington (UW) and Mellor–Yamada–Nakanishi–Niino (MYNN) schemes. Simulations were done for three case studies of extreme rainfall on 17 December 2016, 21 January 2017 and 17 April 2019. The use of YSU produced the highest rainfall peaks across all three cases; however, it produced performance statistics similar to UW that are higher than those of the two other schemes. These statistics are not maintained when adjusted for random hits, indicating that the extra events are mainly random rather than being skillfully placed. UW simulated the lowest PBL height, while MRF produced the highest PBL height, but this was not matched by the temperature simulation. The YSU and MYNN PBL heights were intermediate at the time of the peak; however, MYNN is associated with a slower decay and higher PBL heights at night. WRF underestimated the maximum temperature during all cases and for all PBL schemes, with a larger bias in the MYNN scheme. We support further use of the YSU scheme, which is the scheme selected for the tropical suite in WRF. The different simulations were in some respects more similar to one another than to the available observations. Satellite rainfall estimates and the ERA5 reanalysis showed different rainfall distributions, which indicates a need for more ground observations to assist with studies like this one.
Experimental and Numerical Study of Lattice Girder Composite Slabs with Monolithic Joint
Authors: Zhang Xuefeng , Li Huiming , Liang Shixue , Zhang Hao
Published: February 2021

This paper studies the behavior of lattice girder composite slabs with monolithic joint under bending. A full-scale experiment is performed to investigate the overall bending resistance, deflection and the final crack distribution of latticed girder composite slab under uniformly distributed load. A finite element model is given for the analysis of the latticed girder composite slabs. The effectiveness and correctness of the numerical simulations are verified against experimental results. The experimental and numerical studies conclude that the lattice girder composite slabs conform to the requirement of existing design codes. A parametric study is provided to investigate the effects of lattice girder with following conclusions: (a) the lattice girder significantly increases the stiffness of the slab when comparing with the precast slab without reinforcement crossing the interface; (b) the additional reinforcement near the joint slightly increases the stiffness and resistance, while it prevents damage near the joint.
LC-QTOF/MS Untargeted Metabolomics of Sheep Milk under Cocoa Husks Enriched Diet
Authors: Manis Cristina , Scano Paola , Nudda Anna , Carta Silvia , Pulina Giuseppe , Caboni Pierluigi
Published: February 2021

The aim of this work was to evaluate, by an untargeted metabolomics approach, changes of milk metabolites induced by the replacement of soybean hulls with cocoa husks in the ewes’ diet. Animals were fed with a soybean diet integrated with 50 or 100 g/d of cacao husks. Milk samples were analyzed by an ultra high performance liquid chromatograph coupled to a time of flight mass spectrometer (UHPLC-QTOF-MS) platform. Multivariate statistical analysis showed that the time of sampling profoundly affected metabolite levels, while differences between treatments were evident at the fourth week of sampling. Cocoa husks seem to induce level changes of milk metabolites implicated in the thyroid hormone metabolism and ubiquinol-10 biosynthesis.
Unmanned Aerial Vehicles for Wildland Fires: Sensing, Perception, Cooperation and Assistance
Authors: Akhloufi Moulay A. , Couturier Andy , Castro Nicolás A.
Published: February 2021

Wildfires represent a significant natural risk causing economic losses, human death and environmental damage. In recent years, the world has seen an increase in fire intensity and frequency. Research has been conducted towards the development of dedicated solutions for wildland fire assistance and fighting. Systems were proposed for the remote detection and tracking of fires. These systems have shown improvements in the area of efficient data collection and fire characterization within small-scale environments. However, wildland fires cover large areas making some of the proposed ground-based systems unsuitable for optimal coverage. To tackle this limitation, unmanned aerial vehicles (UAV) and unmanned aerial systems (UAS) were proposed. UAVs have proven to be useful due to their maneuverability, allowing for the implementation of remote sensing, allocation strategies and task planning. They can provide a low-cost alternative for the prevention, detection and real-time support of firefighting. In this paper, previous works related to the use of UAV in wildland fires are reviewed. Onboard sensor instruments, fire perception algorithms and coordination strategies are considered. In addition, some of the recent frameworks proposing the use of both aerial vehicles and unmanned ground vehicles (UGV) for a more efficient wildland firefighting strategy at a larger scale are presented.
Development of Econophysics: A Biased Account and Perspective from Kolkata
Authors: Chakrabarti Bikas K. , Sinha Antika
Published: February 2021

We present here a somewhat personalized account of the emergence of econophysics as an attractive research topic in physical, as well as social, sciences. After a rather detailed storytelling about our endeavors from Kolkata, we give a brief description of the main research achievements in a simple and non-technical language. We also briefly present, in technical language, a piece of our recent research result. We conclude our paper with a brief perspective.
A Survey on Deep Learning Based Methods and Datasets for Monocular 3D Object Detection
Authors: Kim Seong-heum , Hwang Youngbae
Published: February 2021

Owing to recent advancements in deep learning methods and relevant databases, it is becoming increasingly easier to recognize 3D objects using only RGB images from single viewpoints. This study investigates the major breakthroughs and current progress in deep learning-based monocular 3D object detection. For relatively low-cost data acquisition systems without depth sensors or cameras at multiple viewpoints, we first consider existing databases with 2D RGB photos and their relevant attributes. Based on this simple sensor modality for practical applications, deep learning-based monocular 3D object detection methods that overcome significant research challenges are categorized and summarized. We present the key concepts and detailed descriptions of representative single-stage and multiple-stage detection solutions. In addition, we discuss the effectiveness of the detection models on their baseline benchmarks. Finally, we explore several directions for future research on monocular 3D object detection.
On Adaptive Moving Average Algorithms for the Application of the Conservative Power Theory in Systems with Variable Frequency
Authors: Mota Daniel dos Santos , Tedeschi Elisabetta
Published: February 2021

The Conservative Power Theory (CPT) emerged in recent decades as a theoretical framework for coping with harmonically distorted and unbalanced electric networks of ac power systems with a high participation of converter interfaced loads and generation. The CPT measurements are intrinsically linked to moving averages (MA) over one period of the grid. If the CPT is to be used in a low-inertia isolated-grid scenario, which is subjected to frequency variations, adaptive moving averages (AMA) are necessary. This paper reviews an efficient way of computing MAs and turns it into an adaptive one. It shows that an easily available variable time delay block, from MATLAB, causes steady-state errors in the measurements when the grid frequency varies. A new variable time delay block is, thus, proposed. Nonetheless, natural pulsations in the instantaneous power slip through MAs when the discrete moving average window does not fit perfectly the continuously varying period of the grid. A method consisting of weighing two MAs is reviewed and a new and effective hybrid AMA is proposed. The CPT transducers with the different choices of AMAs are compared via computer simulations of a single-phase voltage source feeding either a linear or a nonlinear load.
Early Performance of Tree Species in a Mountain Reforestation Experiment
Authors: Jandl Robert , Kindermann Georg , Foldal Cecilie , Schüler Silvio , Bouissou Christina
Published: February 2021

Climate change requires forest managers to explore new concepts in reforestation. High-elevation sites are posing challenges because the range of tree species that can cope with present and future conditions is small and limited experience with candidate species is available. Methods: We selected a mountain site with nutrient-poor silicatic soils. The previous Norway spruce (Picea abies) stand performed poorly. We established a reforestation experiment with 27 tree species that were planted in different combinations in order to evaluate silvicultural options. Site preparation activities and planting techniques reflected the locally applied regular procedures. After planting, we monitored height growth and phenological characteristics of needle/leaf development in spring. The presently dominant Norway spruce was genetically characterized. Results: Tree seedlings planted at high elevation are highly vulnerable. The temporal course of needle/leaf sprouting varies widely. Early developers are vulnerable to frost, impairing tree development. Biotic stressors such as high population densities of weevils or mice can cause high mortality. Conclusion: we suggest a conservative approach to tree species selection because present site conditions in mountain areas may impair the development of many tree species that could be viable options in a considerably warmer climate.
The Effect of Patterned Micro-Structure on the Apparent Contact Angle and Three-Dimensional Contact Line
Authors: Foltyn Patrick , Restle Ferdinand , Wissmann Markus , Hengsbach Stefan , Weigand Bernhard
Published: February 2021

The measurement of the apparent contact angle on structured surfaces is much more difficult to obtain than on smooth surfaces because the pinning of liquid to the roughness has a tremendous influence on the three phase contact line. The results presented here clearly show an apparent contact angle variation along the three phase contact line. Accordingly, not only one value for the apparent contact angle can be provided, but a contact angle distribution or an interval has to be given to characterize the wetting behavior. For measuring the apparent contact angle distribution on regularly structured surfaces, namely micrometric pillars and grooves, an experimental approach is presented and the results are provided. A short introduction into the manufacturing process of such structured surfaces, which is a combination of Direct LASER Writing (DLW) lithography, electroforming and hot embossing shows the high quality standard of the used surfaces.
Development of Chemometric Models Based on a LC-qToF-MS Approach to Verify the Geographic Origin of Virgin Olive Oil
Authors: Willenberg Ina , Parma Alessandra , Bonte Anja , Matthäus Bertrand
Published: February 2021

In the presented study a non-targeted approach using high-performance liquid chromatography coupled to electrospray ionization quadrupole time-of-flight mass spectrometry (HPLC-ESI-qToF-MS) combined with chemometric techniques was used to build a statistical model to verify the geographic origin of virgin olive oils. The sample preparation by means of liquid/liquid extraction of polar compounds was optimized regarding the number of multiple extractions, application of ultrasonic treatment and temperature during concentration of the analytes. The presented workflow for data processing aimed to identify the most predictive features and was applied to a set of 95 olive oils from Spain, Italy, Portugal and Greece. Different strategies for data reduction and multivariate analysis were compared. Stepwise variable selection showed for both applied multivariate models—linear discriminant analysis (LDA) and logit regression (LR)—to be the most suitable variable selection strategy. The 10-fold cross validation of the LDA showed a classification rate of 83.1% for the test set. For the LR models the prediction accuracy of the test set was even higher with values of 90.4% (Portugal), 86.2% (Italy), 93.8% (Greece) and 88.3% (Spain). Moreover, the reduction of features allows an easier following up strategy for identification of the unknowns and defining marker substances.
Development of a Logic Model for a Programme to Reduce the Magnetic Resonance Imaging Rate for Non-Specific Lower Back Pain in a Tertiary Care Centre
Authors: Alhowimel Ahmed , Alodaibi Faris , Alotaibi Mazyad , Alamam Dalyah , Alsobayel Hana , Fritz Julie
Published: February 2021

Tertiary care centres continue to experience over-utilisation of diagnostic imaging services for lower back pain cases that may not be required. Moreover, these services may require additional time and consequently delay access to services that offer conservative management, i.e., physiotherapy, and hence, increase the direct and indirect costs with no added quality of care. A logic model was developed based on qualitative and quantitative studies that explains the plan and process evaluation strategies to reduce imaging for lower back pain in tertiary hospitals. Logic models are useful tools for defining programme components. The delivery of the components is ensured by well-defined process evaluations that identify any needed modifications. The proposed logic model provides a road map for spine clinics in tertiary care hospitals to decrease the number of patient referrals for magnetic resonance imaging and waiting times for consultations and services and promote early access to physiotherapy services.
Hand Hygiene Knowledge and Self-Reported Hand Washing Behaviors among Restaurant Kitchen Chefs in Jiangsu Province, China
Authors: Cui Bin , Li Shao Ying , Wang Linda Dong-Ling , Chen Xiang , Ke Jun , Tian Yi
Published: February 2021

Inadequate hand washing among chefs is a major contributor to outbreaks of foodborne illnesses originating in restaurants. Although many studies have evaluated hand hygiene knowledge (HHK) and self-reported hand washing behaviors (HWBs) in restaurant workers in different countries, little is known about HHK and HWBs in restaurant kitchen chefs, particularly in China. In this study, we interviewed 453 restaurant kitchen chefs in Jiangsu Province in China regarding their HHK and HWBs and used Chi-square tests (Fisher exact tests), pairwise comparisons, and linear regression models to analyze the responses and identify determinants of HHK and HWBs. Results reveal that less frequent hand washing after leaving work temporarily and after touching used cutlery were the main issues among restaurant kitchen chefs in Jiangsu Province. Kitchen hands had lower levels of HHK and engaged less frequently in good HWBs than the other type of chefs. Furthermore, working in a large restaurant and having worked in the restaurant industry for a longer amount of time were correlated with better HHK and HWBs. These findings suggest that close attention should be paid to the HWBs of chefs during food preparation, that kitchen hands are the key group of restaurant kitchen workers who need training in HHK, and that regulatory activities should focus on small-scale restaurants.
Changes in Prehospital Stroke Care and Stroke Mimic Patterns during the COVID-19 Lockdown
Authors: Melaika Kazimieras , Sveikata Lukas , Wiśniewski Adam , Jaxybayeva Altynshash , Ekkert Aleksandra , Jatužis Dalius , Masiliūnas Rytis
Published: February 2021

The impact of COVID-19 lockdown on prehospital stroke care is largely unknown. We aimed to compare stroke care patterns before and during a state-wide lockdown. Thus, we analysed prospective data of stroke alerts referred to our stroke centre between 1 December 2019 and 16 June 2020, and compared them between two periods—15 weeks before and 13 weeks during the state-wide lockdown declared in Lithuania on 16 March 2020. Among 719 referrals for suspected stroke, there was a decrease in stroke alerts (rate ratio 0.61, 95% CI (0.52–0.71)), stroke admissions (0.63, 95% CI (0.52–0.76)), and decrease in prehospital stroke triage quality (positive predictive value 72.1% vs. 79.9%, p = 0.042) during the lockdown. The onset-to-door time was longer (153.0 vs. 120.5 min, p = 0.049) and seizures and intracranial tumours were more common among stroke mimics (16.9% vs. 6.7%, p = 0.012 and 9.6% vs. 3.0%, p = 0.037, respectively). We conclude that there was a decline in prehospital stroke triage quality during the lockdown despite low COVID-19 incidence in the country. Moreover, we observed an increase in hospital arrival delays and severe conditions presenting as stroke mimics. Our findings suggest that improved strategies are required to maintain optimal neurological care during public health emergencies.
Authentic Youth Engagement in Environmental Health Research and Advocacy
Authors: Cardarelli Kathryn M. , Ickes Melinda , Huntington-Moskos Luz , Wilmhoff Craig , Larck Angela , Pinney Susan M. , Hahn Ellen J.
Published: February 2021

Training in environmental health (EH) engages and inspires youth to tackle health promotion and policy change. Yet, there is little guidance on how to successfully nurture and sustain youth engagement. This paper compares four case studies of youth engagement to promote EH in rural and urban communities using the Youth Empowerment Solutions (YES!) framework. Of the case studies in rural (Central Appalachia) and urban (Cincinnati, Ohio) communities, two employ citizen science approaches using PhotoVoice and environmental sampling; one engages youth in a science communication camp; and one focuses on policy advocacy. We compare and contrast these case studies using the YES! Critical Components and Empowerment levels. The case studies were discussed at the 2020 Partnerships in Environmental Public Health Meeting, where participants identified challenges and possible solutions for promoting and maintaining authentic youth engagement in EH research and advocacy. Analysis of the case studies indicated that youth engagement activities focusing on the individual were more common than those targeting the organizational setting or the community. Youth demonstrate agency to impact EH issues in their communities by engaging in hands-on opportunities to practice citizen science and advocacy. Overcoming challenges to authentic young engagement is important to sustain this work.
The Prevalence and Determinants of Being Offered and Accepting Operational Management Services—A Cohort Study
Authors: Loerbroks Adrian , Scharf Jessica , Angerer Peter , Spanier Katja , Bethge Matthias
Published: February 2021

In Germany, employers are obliged to offer “operational integration management” (OIM) services to employees returning from long-term sick leave. OIM aims to improve employees’ workability and to prevent future sick leave or early retirement. This study examined (i) to what extent OIM services are offered to eligible employees, (ii) to what extent offers are accepted and (iii) the determinants of both outcomes. We used data from a cohort of employees eligible for OIM. Thirty-four potential determinants were assessed in 2013 (i.e., the baseline) using participant reports. In 2015 (i.e., the follow-up), participants were asked (a) whether they had ever been offered OIM services by their employer, and (b) whether they had accepted that offer (i.e., the outcomes). We estimated relative risks by multivariable binomial regression to identify predictors based on backward elimination. In total, 36.0% of the participants were offered OIM services and 77.2% of them accepted that offer. The likelihood of an OIM offer at follow-up was elevated in participants with mental impairment, cancer or long-term absenteeism and increased with organizational justice, neuroticism, and company size. The likelihood of accepting that OIM offer was positively associated with mental impairment and decreased with increasing company size.
Identifying and Analyzing Health-Related Themes in Disinformation Shared by Conservative and Liberal Russian Trolls on Twitter
Authors: Karami Amir , Lundy Morgan , Webb Frank , Turner-McGrievy Gabrielle , McKeever Brooke W. , McKeever Robert
Published: February 2021

To combat health disinformation shared online, there is a need to identify and characterize the prevalence of topics shared by trolls managed by individuals to promote discord. The current literature is limited to a few health topics and dominated by vaccination. The goal of this study is to identify and analyze the breadth of health topics discussed by left (liberal) and right (conservative) Russian trolls on Twitter. We introduce an automated framework based on mixed methods including both computational and qualitative techniques. Results suggest that Russian trolls discussed 48 health-related topics, ranging from diet to abortion. Out of the 48 topics, there was a significant difference (p-value ≤ 0.004) between left and right trolls based on 17 topics. Hillary Clinton’s health during the 2016 election was the most popular topic for right trolls, who discussed this topic significantly more than left trolls. Mental health was the most popular topic for left trolls, who discussed this topic significantly more than right trolls. This study shows that health disinformation is a global public health threat on social media for a considerable number of health topics. This study can be beneficial for researchers who are interested in political disinformation and health monitoring, communication, and promotion on social media by showing health information shared by Russian trolls.
Excess Winter Mortality (EWM) as a Dynamic Forensic Tool: Where, When, Which Conditions, Gender, Ethnicity and Age
Authors: Jones Rodney P
Published: February 2021

To investigate the dynamic issues behind intra- and international variation in EWM (Excess Winter Mortality) using a rolling monthly EWM calculation. This is used to reveal seasonal changes in the EWM calculation and is especially relevant nearer to the equator where EWM does not reach a peak at the same time each year. In addition to latitude country specific factors determine EWM. Females generally show higher EWM. Differences between the genders are highly significant and seem to vary according to the mix of variables active each winter. The EWM for respiratory conditions in England and Wales ranges from 44% to 83%, which is about double the all-cause mortality equivalent. A similar magnitude of respiratory EWM is observed in other temperate countries. Even higher EWM can be seen for specific respiratory conditions. Age has a profound effect on EWM with a peak at puberty and then increases EWM at older ages. The gap between male and female EWM seems to act as a diagnostic tool reflecting the infectious/metrological mix in each winter. Difference due to ethnicity are also observed. An EWM equivalent calculation for sickness absence demonstrates how other health-related variables can be linked to EWM. Midway between the equator and the poles show the highest EWM since such areas tend to neglect the importance of keeping dwellings warm in the winter. Pandemic influenza does not elevate EWM, although seasonal influenza plays a part each winter. Pandemic influenza and changes in influenza strain/variant mix do, however, create structural breaks in the time series and this implies that comparing EWM between studies conducted over different times can be problematic. Cancer is an excellent example of the usefulness of rolling method since cancer EWM drifts each year, in some years increasing winter EWM and in other years diminishing it. In addition, analysis of sub-national EWM in the UK reveals high spatiotemporal granularity indicating roles for infectious outbreaks. The rolling method gives greater insight into the dynamic nature of EWM, which otherwise lies concealed in the current static method.
Strong and Deadly Futures: Co-Development of a Web-Based Wellbeing and Substance Use Prevention Program for Aboriginal and Torres Strait Islander and Non-Aboriginal Adolescents
Authors: Snijder Mieke , Stapinski Lexine , Ward James , Lees Briana , Chapman Cath , Champion Katrina , Doyle Michael , Watson Ian , Sarra Rachael , Lear Amanda , Garlick Bock Sophia , Teesson Maree , Newton Nicola
Published: February 2021

School-based programs can effectively prevent substance use; however, systematic reviews and consultation with stakeholders identified a need for effective, culturally inclusive programs for Aboriginal and/or Torres Strait Islander (hereafter Aboriginal) youth. This paper describes the development of Strong & Deadly Futures, a six-lesson, curriculum-aligned wellbeing and substance use prevention program that was designed for, and with, the Aboriginal youth. Formative reviews and consultation recommended that the program (i) combine effective components of mainstream prevention with cultural elements, highlighting Aboriginal cultural strengths; (ii) avoid stigma and celebrates the cultural diversity by catering to both Aboriginal and non-Aboriginal students; and (iii) use digital technology to enhance engagement, implementation and scalability. Guided by an Appreciative Inquiry approach, the program was developed in partnership with an Indigenous Creative Design Agency, and four schools in New South Wales and Queensland, Australia. Aboriginal (n = 41) and non-Aboriginal students (n = 36) described their role models, positive aspects of their community and reasons to avoid substance use; these formed the basis of an illustrated story which conveyed the key learning outcomes. Feedback from teachers, students and content experts supported the acceptability of the program, which will be evaluated in a subsequent randomised controlled trial.
Feasibility of a Digital Intervention to Promote Healthy Weight Management among Postpartum African American/Black Women
Authors: Napolitano Melissa A. , Harrington Cherise B. , Patchen Loral , Ellis Lindsey P. , Ma Tony , Chang Katie , Gaminian Azar , Bailey Caitlin P. , Evans W. Douglas
Published: February 2021

The study aim was to implement and evaluate the feasibility of a culturally informed (“BeFAB”) app for African American/Black women to address postpartum weight. Women (n = 136; mean age = 27.8 ± 5.4; mean BMI = 32.5 ± 4.3) were recruited from postpartum units, and randomly assigned to receive BeFAB (n = 65) or usual care (n = 71) for 12 weeks. App content included didactic lessons delivered via a virtual coach, app-based messages, goal setting and tracking, and edutainment videos. Feasibility outcomes included recruitment, retention and engagement, and self-reported acceptability. Behavioral (i.e., diet, physical activity), psychosocial (i.e., stress, coping, support, self-efficacy) and weight outcomes were also examined. Recruitment goals were met, but attrition was high, with 56% retention at 12 weeks. Approximately half of participants accessed the app and set a goal ≥one time, but <10% reported achieving a nutrition or activity goal. Among study completers, ≥60% found the app content at least somewhat helpful. Within-group changes for BeFAB among completers were found for increased moderate-to-vigorous physical activity and decreased fruit/vegetable intake and weight. Findings indicate initial feasibility of recruiting postpartum women to participate in a digital healthy body weight program but limited use, reflecting low acceptability and challenges in engagement and retention. Future research is needed on strategies to engage and retain participants in postpartum interventions.
Higher Rates of Low Socioeconomic Status, Marginalization, and Stress in Black Transgender Women Compared to Black Cisgender MSM in The MARI Study
Authors: Russell Jonathan S. , Hickson DeMarc A. , Timmins Liadh , Duncan Dustin T.
Published: February 2021

Most HIV research combines transgender women who have sex with men (TWSM) with cisgender men who have sex with men (MSM), despite emerging evidence of important differences. Using data from The MARI Study, we compared Black TWSM and Black cisgender MSM on personal and ecological factors. Black TWSM reported more unemployment (71.4% versus 51.4%, p = 0.015), incarceration (52.4% versus 36.0%, p = 0.046), stressful life experiences (median score 135.5 versus 90, p = 0.033), and HIV positivity (66.7% versus 22.9%, p = 0.008). Further research into the causes and consequences of these differences, and regarding TWSM specifically, is needed.
Psychological Impact of Pro-Anorexia and Pro-Eating Disorder Websites on Adolescent Females: A Systematic Review
Authors: Mento Carmela , Silvestri Maria Catena , Muscatello Maria Rosaria Anna , Rizzo Amelia , Celebre Laura , Praticò Martina , Zoccali Rocco Antonio , Bruno Antonio
Published: February 2021

(1) Background: Teenagers (in particular, females) suffering from eating disorders report being not satisfied with their physical aspect and they often perceive their body image in a wrong way; they report an excessive use of websites, defined as PRO-ANA and PRO-MIA, that promote an ideal of thinness, providing advice and suggestions about how to obtain super slim bodies. (2) Aim: The aim of this review is to explore the psychological impact of pro-ana and pro-mia websites on female teenagers. (3) Methods: We have carried out a systematic review of the literature on PubMed. The search terms that have been used are: “Pro” AND “Ana” OR “Blogging” AND “Mia”. Initially, 161 publications were identified, but in total, in compliance with inclusion and exclusion criteria, 12 studies have been analyzed. (4) Results: The recent scientific literature has identified a growing number of Pro Ana and Pro Mia blogs which play an important role in the etiology of anorexia and bulimia, above all in female teenagers. The feelings of discomfort and dissatisfaction with their physical aspect, therefore, reduce their self-esteem. (5) Conclusion: These websites encourage anorexic and bulimic behaviors, in particular in female teenagers. Attention to healthy eating guidelines and policies during adolescence, focused on correcting eating behavioral aspects, is very important to prevent severe forms of psychopathology with more vulnerability in the perception of body image, social desirability, and negative emotional feedback.
Who Guides Vaccination in the Portuguese Press? An Analysis of Information Sources
Authors: Langbecker Andrea , Catalan-Matamoros Daniel
Published: February 2021

Sources of information are a key part of the news process as it guides certain topics, influencing the media agenda. The goal of this study is to examine the most frequent voices on vaccines in the Portuguese press. A total of 300 news items were analysed via content analysis using as sources two newspapers from 2012 to 2017. Of all the articles, 97.7% included a source (n = 670). The most frequent were “governmental organisations”, “professional associations” and the “media”. Less frequent sources were “university scientists”, “governmental scientific bodies”, “consumer groups”, “doctors”, “scientific companies”, “NGOs” and “scientific journals”. Most articles used only non-scientific sources (n = 156). A total of 94 articles used both categories and 43 used exclusively scientific sources. Our findings support the assertion that media can be an instrument to disseminate information on vaccines. Nevertheless, despite being present in most articles, the number of sources per article was low, therefore not presenting a diversity of opinions and there was a lack of scientific voices, thus suggesting lower quality of the information being offered to the audience.
Spontaneous Pneumothorax in COVID-19 Patients Treated with High-Flow Nasal Cannula outside the ICU: A Case Series
Authors: Nalewajska Magdalena , Feret Wiktoria , Wojczyński Łukasz , Witkiewicz Wojciech , Wiśniewska Magda , Kotfis Katarzyna
Published: February 2021

The coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global pandemic and a burden to global health at the turn of 2019 and 2020. No targeted treatment for COVID-19 infection has been identified so far, thus supportive treatment, invasive and non-invasive oxygen support, and corticosteroids remain a common therapy. High-flow nasal cannula (HFNC), a non-invasive oxygen support method, has become a prominent treatment option for respiratory failure during the SARS-CoV-2 pandemic. HFNC reduces the anatomic dead space and increases positive end-expiratory pressure (PEEP), allowing higher concentrations and higher flow of oxygen. Some studies suggest positive effects of HFNC on mortality and avoidance of intubation. Spontaneous pneumothorax has been observed in patients suffering from SARS-CoV-2 pneumonia. Although the viral infection itself contributes to its development, higher PEEP generated by both HFNC and mechanical ventilation is another risk factor for increased alveoli damage and air-leak. Herein, we present three cases of patients with no previous history of lung diseases who were diagnosed with COVID-19 viral pneumonia. All of them were supported with HFNC, and all of them presented spontaneous pneumothorax.
Preventing Violence toward Sexual and Cultural Diversity: The Role of a Queering Sex Education
Authors: Carrera-Fernández Maria Victoria , Lameiras-Fernández María , Blanco-Pardo Nazaret , Rodríguez-Castro Yolanda
Published: February 2021

Background: The prevailing sex education (SE) model falls within a neoliberal prevention- and risk-oriented paradigm. This model ignores the identity dimension of sexuality, is based on the cis-heteronormative and ethnocentric matrix and stigmatizes sexual and cultural diversity; this has significant consequences for sexually and culturally diverse adolescents and youth. In this study, we explored the potential of the identity dimension of SE to prevent violence toward sexual and cultural diversity. Specifically, our objective was to identify the influence of heteronormative and ethnocentric variables on violence exerted against trans* and gender-diverse people and people from minority ethnic groups. Methods: A total of 623 Spanish adolescents with a mean age of 14.73 years and an age range of 13 to 18 years participated in the study. Students completed a questionnaire that included measures regarding violence toward sexual and cultural diversity, gender stereotypes, sexist attitudes and rejection of sexual and cultural diversity. We performed two hierarchical linear regression models. Results: Students who exerted the highest amount of violence toward trans* and gender-diverse people were those who showed the lowest endorsement of expressive traits and the highest endorsement of instrumental traits as well as the highest level of hostile sexist, heteronormative and hostile racist attitudes (the five predictor variables explained 29.1% of the variance of gender-bashing). These same variables—except expressiveness—and benevolent sexism explained 46.1% of the variance of rejection of minority ethnic groups. Conclusions: There is a need for a comprehensive, intercultural, critical and queer SE aimed at transforming the classroom into a space that promotes social transformation through an educational practice that is transgressive and critical of cis-heteronormativity and normative ethnocentrism.
Escaping from Cities during the COVID-19 Crisis: Using Mobile Phone Data to Trace Mobility in Finland
Authors: Willberg Elias , Järv Olle , Väisänen Tuomas , Toivonen Tuuli
Published: February 2021

The coronavirus disease 2019 (COVID-19) crisis resulted in unprecedented changes in the spatial mobility of people across societies due to the restrictions imposed. This also resulted in unexpected mobility and population dynamics that created a challenge for crisis preparedness, including the mobility from cities during the crisis due to the underlying phenomenon of multi-local living. People changing their residences can spread the virus between regions and create situations in which health and emergency services are not prepared for the population increase. Here, our focus is on urban–rural mobility and the influence of multi-local living on population dynamics in Finland during the COVID-19 crisis in 2020. Results, based on three mobile phone datasets, showed a significant drop in inter-municipal mobility and a shift in the presence of people—a population decline in urban centres and an increase in rural areas, which is strongly correlated to secondary housing. This study highlights the need to improve crisis preparedness by: (1) acknowledging the growing importance of multi-local living, and (2) improving the use of novel data sources for monitoring population dynamics and mobility. Mobile phone data products have enormous potential, but attention should be paid to the varying methodologies and their possible impact on analysis.