bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary File from Improved Tumor Penetration and Single-Cell Targeting of Antibody–Drug Conjugates Increases Anticancer Efficacy and Host Survival
Authors: Cilliers Cornelius , Menezes Bruna , Nessler Ian , Linderman Jennifer , Thurber Greg M.
Published: March 2023

The supplementary data file includes additional immunofluorescence microscopy images showing the tumor distribution of T-DM1-680 alone, T-DM1-680 with unlabeled trastuzumab, and a higher dose of T-DM1-680. Supplemental in vitro assays include: single-agent trastuzumab cytotoxicity, cytotoxicity and quantitative uptake with constant total antibody concentration but different T-DM1 concentration, ADC cellular binding affinity with and without fluorophores, ADC cellular toxicity with and without fluorophores, and quantitative cellular uptake and degradation of dually labeled T-DM1. Supplemental in vivo data include: Kaplan-Meier curves with confidence intervals for each dosing level, individual tumor growth curves for each animal, mouse weight change during treatment, and plasma clearance of fluorescently labeled trastuzumab. The file also contains supplementary methods for immunofluorescence histology and surface to volume image analysis, and a supplementary discussion on the importance of bystander effects.
Figure S4 from CXCR4 Promotes Neuroblastoma Growth and Therapeutic Resistance through miR-15a/16-1–Mediated ERK and BCL2/Cyclin D1 Pathways
Authors: Klein Shiri , Abraham Michal , Bulvik Baruch , Dery Elia , Weiss Ido D. , Barashi Neta , Abramovitch Rinat , Wald Hanna , Harel Yaniv , Olam Devorah , Weiss Lola , Beider Katia , Eizenberg Orly , Wald Ori , Galun Eithan , Pereg Yaron , Peled Amnon
Published: March 2023

BCL2 levels in SKNBE-CXCR4 cells
Figure S1 from CXCR4 Promotes Neuroblastoma Growth and Therapeutic Resistance through miR-15a/16-1–Mediated ERK and BCL2/Cyclin D1 Pathways
Authors: Klein Shiri , Abraham Michal , Bulvik Baruch , Dery Elia , Weiss Ido D. , Barashi Neta , Abramovitch Rinat , Wald Hanna , Harel Yaniv , Olam Devorah , Weiss Lola , Beider Katia , Eizenberg Orly , Wald Ori , Galun Eithan , Pereg Yaron , Peled Amnon
Published: March 2023

CXCL12 levels of NB cells
Supplemental methods from Amplification of Oncolytic Vaccinia Virus Widespread Tumor Cell Killing by Sunitinib through Multiple Mechanisms
Authors: Kim Minah , Nitschké Maximilian , Sennino Barbara , Murer Patrizia , Schriver Brian J. , Bell Alexander , Subramanian Aishwarya , McDonald Corry E. , Wang Jiahu , Cha Howard , Bourgeois-Daigneault Marie-Claude , Kirn David H. , Bell John C. , De Silva Naomi , Breitbach Caroline J. , McDonald Donald M.
Published: March 2023

Methods for immunohistochemistry, sectioning, and flow cytometry
Figure S4 from miR-139-5p Modulates Radiotherapy Resistance in Breast Cancer by Repressing Multiple Gene Networks of DNA Repair and ROS Defense
Authors: Pajic Marina , Froio Danielle , Daly Sheridan , Doculara Louise , Millar Ewan , Graham Peter H. , Drury Alison , Steinmann Angela , de Bock Charles E. , Boulghourjian Alice , Zaratzian Anaiis , Carroll Susan , Toohey Joanne , O’Toole Sandra A. , Harris Adrian L , Buffa Francesca M. , Gee Harriet E. , Hollway Georgina E. , Molloy Timothy J.
Published: March 2023

RT + miR-139-5p mimic-treated tumours had significantly decreased Ki-67-positive cells, and significantly increased phospho-H2AX- and caspase-3-positive cells compared to control mimic-treated tumours (A-C). phospho-H2AX immunostaining was confined to the tumour field that received the radiation; the kidneys and liver, non-target organs that were not within the radiation field but which accumulated miRNA mimic did not have detectable phospho-H2AX expression (D-E).
Figure S1 from PTBP3-Mediated Regulation of ZEB1 mRNA Stability Promotes Epithelial–Mesenchymal Transition in Breast Cancer
Authors: Hou Pingfu , Li Lin , Chen Fang , Chen Yansu , Liu Hui , Li Jingjing , Bai Jin , Zheng Junnian
Published: March 2023

Figure S1 shows that PTBP3 mRNA expression is predictive of poor outcome in breast cancer patients in TCGA dataset
Supplemental Table S2 from MYC Targeted Long Noncoding RNA DANCR Promotes Cancer in Part by Reducing p21 Levels
Authors: Lu Yunqi , Hu Zhongyi , Mangala Lingegowda S. , Stine Zachary E. , Hu Xiaowen , Jiang Dahai , Xiang Yan , Zhang Youyou , Pradeep Sunila , Rodriguez-Aguayo Cristian , Lopez-Berestein Gabriel , DeMarzo Angelo M. , Sood Anil K. , Zhang Lin , Dang Chi V.
Published: March 2023

Table S2. Myc-regulated lncRNAs in P493-6 cell line Table S2 provides the expression profiles of long non-coding RNAs (lncRNAs) in response to MYC induction.
Supplemental Table S1 from MYC Targeted Long Noncoding RNA DANCR Promotes Cancer in Part by Reducing p21 Levels
Authors: Lu Yunqi , Hu Zhongyi , Mangala Lingegowda S. , Stine Zachary E. , Hu Xiaowen , Jiang Dahai , Xiang Yan , Zhang Youyou , Pradeep Sunila , Rodriguez-Aguayo Cristian , Lopez-Berestein Gabriel , DeMarzo Angelo M. , Sood Anil K. , Zhang Lin , Dang Chi V.
Published: March 2023

Table S1. MYC-regulated genes in P493-6 cell line Table S1 provides expression profiles of genes in response to MYC induction in the lymphoma model cell line P493-6.
Metabolome dataset from Lapatinib Resistance in Breast Cancer Cells Is Accompanied by Phosphorylation-Mediated Reprogramming of Glycolysis
Authors: Ruprecht Benjamin , Zaal Esther A. , Zecha Jana , Wu Wei , Berkers Celia R. , Kuster Bernhard , Lemeer Simone
Published: March 2023

Metabolome dataset containing processed quantitative data for intracellular metabolites and processed quantitative data for extracellular metabolites.
Figure S7 from Silencing the Snail-Dependent RNA Splice Regulator ESRP1 Drives Malignant Transformation of Human Pulmonary Epithelial Cells
Authors: Walser Tonya C. , Jing Zhe , Tran Linh M. , Lin Ying Q. , Yakobian Natalie , Wang Gerald , Krysan Kostyantyn , Zhu Li X. , Sharma Sherven , Lee Mi-Heon , Belperio John A. , Ooi Aik T. , Gomperts Brigitte N. , Shay Jerry W. , Larsen Jill E. , Minna John D. , Hong Long-sheng , Fishbein Michael C. , Dubinett Steven M.
Published: March 2023

Figure S7 provides additional evidence that Snail malignantly transforms epithelial cells in vivo. Information on the stem cell phenotype of the cells transformed by Snail is provided.
Supplementary Figures from slan+ Monocytes and Macrophages Mediate CD20-Dependent B-cell Lymphoma Elimination via ADCC and ADCP
Authors: Vermi William , Micheletti Alessandra , Finotti Giulia , Tecchio Cristina , Calzetti Federica , Costa Sara , Bugatti Mattia , Calza Stefano , Agostinelli Claudio , Pileri Stefano , Balzarini Piera , Tucci Alessandra , Rossi Giuseppe , Furlani Lara , Todeschini Giuseppe , Zamò Alberto , Facchetti Fabio , Lorenzi Luisa , Lonardi Silvia , Cassatella Marco A.
Published: March 2023

The file contains 8 supplementary Figures displaying results in support of the data described in the results section.
STR DNA Profiling for Cell Line Authentication from Small-Molecule Activators of Protein Phosphatase 2A for the Treatment of Castration-Resistant Prostate Cancer
Authors: McClinch Kimberly , Avelar Rita A. , Callejas David , Izadmehr Sudeh , Wiredja Danica , Perl Abbey , Sangodkar Jaya , Kastrinsky David B. , Schlatzer Daniela , Cooper Maxwell , Kiselar Janna , Stachnik Agnes , Yao Shen , Hoon Divya , McQuaid Daniel , Zaware Nilesh , Gong Yixuan , Brautigan David L. , Plymate Stephen R. , Sprenger Cynthia C.T. , Oh William K. , Levine Alice C. , Kirschenbaum Alexander , Sfakianos John P. , Sears Rosalie , DiFeo Analisa , Ioannou Yiannis , Ohlmeyer Michael , Narla Goutham , Galsky Matthew D.
Published: March 2023

STR DNA Profiling for Cell Line Authentication
Supplementary Figure S2 from LSR Antibody Therapy Inhibits Ovarian Epithelial Tumor Growth by Inhibiting Lipid Uptake
Authors: Hiramatsu Kosuke , Serada Satoshi , Enomoto Takayuki , Takahashi Yusuke , Nakagawa Satoshi , Nojima Satoshi , Morimoto Akiko , Matsuzaki Shinya , Yokoyama Takuhei , Takahashi Tsuyoshi , Fujimoto Minoru , Takemori Hiroshi , Ueda Yutaka , Yoshino Kiyoshi , Morii Eiichi , Kimura Tadashi , Naka Tetsuji
Published: March 2023

This Figure shows anti-tumor activity of anti-hLSR mAb (#1-25) in EOC xenografts using SCID mice
Supplementary Information from Improved Evaluation of Antivascular Cancer Therapy Using Constrained Tracer-Kinetic Modeling for Multiagent Dynamic Contrast-Enhanced MRI
Authors: Hectors Stefanie J. , Jacobs Igor , Lok Jasper , Peters Johannes , Bussink Johan , Hoeben Freek J. , Keizer Henk M. , Janssen Henk M. , Nicolay Klaas , Schabel Matthias C. , Strijkers Gustav J.
Published: March 2023

This file contains supplementary information on dendrimer synthesis and characterization and on the histopathological analysis of tumor perfusion.
Supplementary Table S2 from ER Stress Signaling Promotes the Survival of Cancer “Persister Cells” Tolerant to EGFR Tyrosine Kinase Inhibitors
Authors: Terai Hideki , Kitajima Shunsuke , Potter Danielle S. , Matsui Yusuke , Quiceno Laura Gutierrez , Chen Ting , Kim Tae-jung , Rusan Maria , Thai Tran C. , Piccioni Federica , Donovan Katherine A. , Kwiatkowski Nicholas , Hinohara Kunihiko , Wei Guo , Gray Nathanael S. , Fischer Eric S. , Wong Kwok-Kin , Shimamura Teppei , Letai Anthony , Hammerman Peter S. , Barbie David A.
Published: March 2023

Result of GSEA analysis
Supplementary Methods from ER Stress Signaling Promotes the Survival of Cancer “Persister Cells” Tolerant to EGFR Tyrosine Kinase Inhibitors
Authors: Terai Hideki , Kitajima Shunsuke , Potter Danielle S. , Matsui Yusuke , Quiceno Laura Gutierrez , Chen Ting , Kim Tae-jung , Rusan Maria , Thai Tran C. , Piccioni Federica , Donovan Katherine A. , Kwiatkowski Nicholas , Hinohara Kunihiko , Wei Guo , Gray Nathanael S. , Fischer Eric S. , Wong Kwok-Kin , Shimamura Teppei , Letai Anthony , Hammerman Peter S. , Barbie David A.
Published: March 2023

Supplementary Methods for detailed screening methods and the materials used.
Figure S3 from Delivering Type I Interferon to Dendritic Cells Empowers Tumor Eradication and Immune Combination Treatments
Authors: Cauwels Anje , Van Lint Sandra , Paul Franciane , Garcin Geneviève , De Koker Stefaan , Van Parys Alexander , Wueest Thomas , Gerlo Sarah , Van der Heyden José , Bordat Yann , Catteeuw Dominiek , Rogge Elke , Verhee Annick , Vandekerckhove Bart , Kley Niko , Uzé Gilles , Tavernier Jan
Published: March 2023

Clec9A-targeting does not induce hematological deficits.
Figure S1 from Cancer-Associated Fibroblasts Drive Glycolysis in a Targetable Signaling Loop Implicated in Head and Neck Squamous Cell Carcinoma Progression
Authors: Kumar Dhruv , New Jacob , Vishwakarma Vikalp , Joshi Radhika , Enders Jonathan , Lin Fangchen , Dasari Sumana , Gutierrez Wade R. , Leef George , Ponnurangam Sivapriya , Chavan Hemantkumar , Ganaden Lydia , Thornton Mackenzie M. , Dai Hongying , Tawfik Ossama , Straub Jeffrey , Shnayder Yelizaveta , Kakarala Kiran , Tsue Terance Ted , Girod Douglas A. , Van Houten Bennett , Anant Shrikant , Krishnamurthy Partha , Thomas Sufi Mary
Published: March 2023

HNSCC Cells have Higher Glycolytic Capacity than CAFs and CAFs have Higher Maximal Respiration than HNSCC.
Supplemental Methods from High-Throughput Genomic Profiling of Adult Solid Tumors Reveals Novel Insights into Cancer Pathogenesis
Authors: Hartmaier Ryan J. , Albacker Lee A. , Chmielecki Juliann , Bailey Mark , He Jie , Goldberg Michael E. , Ramkissoon Shakti , Suh James , Elvin Julia A. , Chiacchia Samuel , Frampton Garrett M. , Ross Jeffrey S. , Miller Vincent , Stephens Philip J. , Lipson Doron
Published: March 2023

Details for variant processing, analysis of TCGA data, and the FM mutation hotspot caller.
Supplementary_Methods from LNMICC Promotes Nodal Metastasis of Cervical Cancer by Reprogramming Fatty Acid Metabolism
Authors: Shang Chunliang , Wang Wei , Liao Yuandong , Chen Yili , Liu Tianyu , Du Qiqiao , Huang Jiaming , Liang Yanchun , Liu Junxiu , Zhao Yunhe , Guo Luyan , Hu Zheng , Yao Shuzhong
Published: March 2023

Supplementary_Methods show the detailed experimental methods used in our paper.
Sup Fig 8 from New Mechanisms of Resistance to MEK Inhibitors in Melanoma Revealed by Intravital Imaging
Authors: Brighton Hailey E. , Angus Steven P. , Bo Tao , Roques Jose , Tagliatela Alicia C. , Darr David B. , Karagoz Kubra , Sciaky Noah , Gatza Michael L. , Sharpless Norman E. , Johnson Gary L. , Bear James E.
Published: March 2023

Graphical representation and model of results
Supplementary Figure 5 from Atypical G Protein β5 Promotes Cardiac Oxidative Stress, Apoptosis, and Fibrotic Remodeling in Response to Multiple Cancer Chemotherapeutics
Authors: Chakraborti Sreemoyee , Pramanick Arnab , Saha Sudipta , Roy Somnath Singha , Chaudhuri Arnab Ray , Das Madhusudan , Ghosh Sujoy , Stewart Adele , Maity Biswanath
Published: March 2023

Figure S5. Nox-dependent ROS generation promotes activation of CaMKII and ATM following chemotherapy exposure.
Supplementary Figure 1 from Atypical G Protein β5 Promotes Cardiac Oxidative Stress, Apoptosis, and Fibrotic Remodeling in Response to Multiple Cancer Chemotherapeutics
Authors: Chakraborti Sreemoyee , Pramanick Arnab , Saha Sudipta , Roy Somnath Singha , Chaudhuri Arnab Ray , Das Madhusudan , Ghosh Sujoy , Stewart Adele , Maity Biswanath
Published: March 2023

Figure S1. Gβ5 upregulation following chemotherapeutic drug exposure requires new protein synthesis.
Figure S1 from The E3 Ligase RING1 Targets p53 for Degradation and Promotes Cancer Cell Proliferation and Survival
Authors: Shen Jiajia , Li Pengyu , Shao Xuejing , Yang Yang , Liu Xiujun , Feng Min , Yu Qiang , Hu Ronggui , Wang Zhen
Published: March 2023

Efficiency of RING1 knockdown and its effect on the transcriptional activity of p21
Table S3 from Enhancer Remodeling and MicroRNA Alterations Are Associated with Acquired Resistance to ALK Inhibitors
Authors: Yun Mi Ran , Lim Sun Min , Kim Seon-Kyu , Choi Hun Mi , Pyo Kyoung-Ho , Kim Seong Keun , Lee Ji Min , Lee You Won , Choi Jae Woo , Kim Hye Ryun , Hong Min Hee , Haam Keeok , Huh Nanhyung , Kim Jong-Hwan , Kim Yong Sung , Shim Hyo Sup , Soo Ross Andrew , Shih Jin-Yuan , Yang James Chih-Hsin , Kim Mirang , Cho Byoung Chul
Published: March 2023

Gene expression levels in H3122, LR, and panobinostat treated LR cells and the promoter or enhancer H3K27 ac gain or loss
Supplementary Figure 2 from Pomalidomide Inhibits PD-L1 Induction to Promote Antitumor Immunity
Authors: Fujiwara Yuki , Sun Yi , Torphy Robert J. , He Jiadai , Yanaga Katsuhiko , Edil Barish H. , Schulick Richard D. , Zhu Yuwen
Published: March 2023

Figure S2
Supplementary tables from Peli1 Modulates the Subcellular Localization and Activity of Mdmx
Authors: Li Dawei , Tavana Omid , Sun Shao-Cong , Gu Wei
Published: March 2023

Proteins identified in the MDMX complex and Demographic and clinical characteristics in the patients with cutaneous melanoma
Figure S4 from Anti-CD137 Suppresses Tumor Growth by Blocking Reverse Signaling by CD137 Ligand
Authors: Kang Sang W. , Lee Sang C. , Park So H. , Kim Juyang , Kim Hyeon H. , Lee Hyeon-Woo , Seo Su K. , Kwon Byoung S. , Cho Hong R. , Kwon Byungsuk
Published: March 2023

Bone marrow cells of WT or CD137-/- mice were cultured in plates coated with human IgG1 or CD137-Fc¬ in the presence of murine Flt3L for 9 d. IFN-gamma and GM-CSF were added, and cells were cultured for an additional 2 d to polarize differentiated DCs toward CD103+ subsets. CD103+ DCs (middle panel) were gated from CD11c+F4/80- cells (upper panel). Macrophages are categorized as F4/80+CD11b+CD11c+ or F4/80+CD11b+CD11c- cells (upper and lower panels).
Figures S4 & S5 from Lysyl Oxidase–like Protein LOXL2 Promotes Lung Metastasis of Breast Cancer
Authors: Salvador Fernando , Martin Alberto , López-Menéndez Celia , Moreno-Bueno Gema , Santos Vanesa , Vázquez-Naharro Alberto , Santamaría Patricia G. , Morales Saleta , Dubus Pierre R. , Muinelo-Romay Laura , López-López Rafael , Tung Jason C. , Weaver Valerie M. , Portillo Francisco , Cano Amparo
Published: March 2023

Lung metastatis burden (Fig. S4) and CTCs content (Fig. S5) in 14-weeks PyMT mice with deregulated Loxl2
Supplementary Tables from O-GlcNAcylation of the Tumor Suppressor FOXO3 Triggers Aberrant Cancer Cell Growth
Authors: Shin Heon , Cha Hyun-Jeong , Na Keun , Lee Min Jung , Cho Jin-Young , Kim Chae-Yeon , Kim Eun Kyung , Kang Chang Moo , Kim Hoguen , Paik Young-Ki
Published: March 2023

This file contains all Supplementary tables that include protein identification and pathway description.
Figure S1 from Transplantation of iPS-Derived Tumor Cells with a Homozygous MHC Haplotype Induces GRP94 Antibody Production in MHC-Matched Macaques
Authors: Ishigaki Hirohito , Maeda Toshinaga , Inoue Hirokazu , Akagi Tsuyoshi , Sasamura Takako , Ishida Hideaki , Inubushi Toshiro , Okahara Junko , Shiina Takashi , Nakayama Misako , Itoh Yasushi , Ogasawara Kazumasa
Published: March 2023

Soft agar colony forming assay of PTY cells and NPCPR cells
Supplementary Figure 3 from Enhanced Acid Sphingomyelinase Activity Drives Immune Evasion and Tumor Growth in Non–Small Cell Lung Carcinoma
Authors: Kachler Katerina , Bailer Maximilian , Heim Lisanne , Schumacher Fabian , Reichel Martin , Holzinger Corinna D. , Trump Sonja , Mittler Susanne , Monti Juliana , Trufa Denis I. , Rieker Ralf J. , Hartmann Arndt , Sirbu Horia , Kleuser Burkhard , Kornhuber Johannes , Finotto Susetta
Published: March 2023

Regulation of T cell phenotype and serum Ceramide/Sphingomyelin levels in wild type and ASM KO naïve and lung tumour bearing mice
Supplementary Table 2 from The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation
Authors: Weissmann Simon , Cloos Paul A. , Sidoli Simone , Jensen Ole N. , Pollard Steven , Helin Kristian
Published: March 2023

Supplementary Table 2 lists regions bound by CIC (Peaks) in mouse ESCs (mESCs), human neural stem cell (hNSC) lines 18.5 and 21.5 and human glioma neural stem cell (GNS) line G144 as well as target genes common across all studied cell lines.
Figure S2 from Glycoprotein nmb Is Exposed on the Surface of Dormant Breast Cancer Cells and Induces Stem Cell–like Properties
Authors: Chen Chen , Okita Yukari , Watanabe Yukihide , Abe Fumie , Fikry Muhammad Ali , Ichikawa Yumu , Suzuki Hiroyuki , Shibuya Akira , Kato Mitsuyasu
Published: March 2023

Effects of Gpnmb knockdown on cancer stem cell-like properties in 4T1 cells.
Online Supplementary Materials from A Transcriptome-Wide Association Study Among 97,898 Women to Identify Candidate Susceptibility Genes for Epithelial Ovarian Cancer Risk
Authors: Lu Yingchang , Beeghly-Fadiel Alicia , Wu Lang , Guo Xingyi , Li Bingshan , Schildkraut Joellen M. , Im Hae Kyung , Chen Yian A. , Permuth Jennifer B. , Reid Brett M. , Teer Jamie K. , Moysich Kirsten B. , Andrulis Irene L. , Anton-Culver Hoda , Arun Banu K. , Bandera Elisa V. , Barkardottir Rosa B. , Barnes Daniel R. , Benitez Javier , Bjorge Line , Brenton James , Butzow Ralf , Caldes Trinidad , Caligo Maria A. , Campbell Ian , Chang-Claude Jenny , Claes Kathleen B.M. , Couch Fergus J. , Cramer Daniel W. , Daly Mary B. , deFazio Anna , Dennis Joe , Diez Orland , Domchek Susan M. , Dörk Thilo , Easton Douglas F. , Eccles Diana M. , Fasching Peter A. , Fortner Renée T. , Fountzilas George , Friedman Eitan , Ganz Patricia A. , Garber Judy , Giles Graham G. , Godwin Andrew K. , Goldgar David E. , Goodman Marc T. , Greene Mark H. , Gronwald Jacek , Hamann Ute , Heitz Florian , Hildebrandt Michelle A.T. , Høgdall Claus K. , Hollestelle Antoinette , Hulick Peter J. , Huntsman David G. , Imyanitov Evgeny N. , Isaacs Claudine , Jakubowska Anna , James Paul , Karlan Beth Y. , Kelemen Linda E. , Kiemeney Lambertus A. , Kjaer Susanne K. , Kwong Ava , Le Nhu D. , Leslie Goska , Lesueur Fabienne , Levine Douglas A. , Mattiello Amalia , May Taymaa , McGuffog Lesley , McNeish Iain A. , Merritt Melissa A. , Modugno Francesmary , Montagna Marco , Neuhausen Susan L. , Nevanlinna Heli , Nielsen Finn C. , Nikitina-Zake Liene , Nussbaum Robert L. , Offit Kenneth , Olah Edith , Olopade Olufunmilayo I. , Olson Sara H. , Olsson Håkan , Osorio Ana , Park Sue K. , Parsons Michael T. , Peeters Petra H.M. , Pejovic Tanja , Peterlongo Paolo , Phelan Catherine M. , Pujana Miquel Angel , Ramus Susan J. , Rennert Gad , Risch Harvey , Rodriguez Gustavo C. , Rodríguez-Antona Cristina , Romieu Isabelle , Rookus Matti A. , Rossing Mary Anne , Rzepecka Iwona K. , Sandler Dale P. , Schmutzler Rita K. , Setiawan Veronica W. , Sharma Priyanka , Sieh Weiva , Simard Jacques , Singer Christian F. , Song Honglin , Southey Melissa C. , Spurdle Amanda B. , Sutphen Rebecca , Swerdlow Anthony J. , Teixeira Manuel R. , Teo Soo H. , Thomassen Mads , Tischkowitz Marc , Toland Amanda E. , Trichopoulou Antonia , Tung Nadine , Tworoger Shelley S. , van Rensburg Elizabeth J. , Vanderstichele Adriaan , Vega Ana , Edwards Digna Velez , Webb Penelope M. , Weitzel Jeffrey N. , Wentzensen Nicolas , White Emily , Wolk Alicja , Wu Anna H. , Yannoukakos Drakoulis , Zorn Kristin K. , Gayther Simon A. , Antoniou Antonis C. , Berchuck Andrew , Goode Ellen L. , Chenevix-Trench Georgia , Sellers Thomas A. , Pharoah Paul D.P. , Zheng Wei , Long Jirong
Published: March 2023

Online Supplementary Documents
Supplementary Figure Legends from Transketolase Regulates the Metabolic Switch to Control Breast Cancer Cell Metastasis via the α-Ketoglutarate Signaling Pathway
Authors: Tseng Chien-Wei , Kuo Wen-Hung , Chan Shih-Hsuan , Chan Hong-Lin , Chang King-Jen , Wang Lu-Hai
Published: March 2023

Legends for supplementary Figure S1-S6
Supplementary Tables S1 and S2 from A RIPK3-PGE2 Circuit Mediates Myeloid-Derived Suppressor Cell–Potentiated Colorectal Carcinogenesis
Authors: Yan Guifang , Zhao Huakan , Zhang Qi , Zhou Yu , Wu Lei , Lei Juan , Wang Xiang , Zhang Jiangang , Zhang Xiao , Zheng Lu , Du Guangsheng , Xiao Weidong , Tang Bo , Miao Hongming , Li Yongsheng
Published: March 2023

Supplementary tables of human clinical characteristics of samples and database GSE17536
Supplementary Data from Genomic Characterization of Six Virus-Associated Cancers Identifies Changes in the Tumor Immune Microenvironment and Altered Genetic Programs
Authors: Varn Frederick S. , Schaafsma Evelien , Wang Yue , Cheng Chao
Published: March 2023

Supplementary Table S6: AUC comparison between virus signature and regularized logistic regression approaches in HNSC.
Figure S1 from The Circular RNA circPRKCI Promotes Tumor Growth in Lung Adenocarcinoma
Authors: Qiu Mantang , Xia Wenjia , Chen Rui , Wang Siwei , Xu Youtao , Ma Zhifei , Xu Weizhang , Zhang Erbao , Wang Jie , Fang Tian , Hu Jingwen , Dong Gaochao , Yin Rong , Wang Jun , Xu Lin
Published: March 2023

circPRKCI promotes the malignant progression of LAC cells. A-I: Consistent with the SPC-A1 cells, all functional experiments were repeated in A549 cells. Silence of circPRKCI did not affect apoptosis in SPC-A1 cells (J, K). Transwell assay in SPC-A1 cells (L). ** P <0.01, N.S: not significant; NC: negative control; EV: empty vector
Supplementary material from Mathematical Modeling Predicts Response to Chemotherapy and Drug Combinations in Ovarian Cancer
Authors: Kozłowska Emilia , Färkkilä Anniina , Vallius Tuulia , Carpén Olli , Kemppainen Jukka , Grénman Seija , Lehtonen Rainer , Hynninen Johanna , Hietanen Sakari , Hautaniemi Sampsa
Published: March 2023

Detailed description of mathematical model and parameter estimation.
Figure S4 from Macrophage-Derived Neuropilin-2 Exhibits Novel Tumor-Promoting Functions
Authors: Roy Sohini , Bag Arup K. , Dutta Samikshan , Polavaram Navatha Shree , Islam Ridwan , Schellenburg Samuel , Banwait Jasjit , Guda Chittibabu , Ran Sophia , Hollingsworth Michael A. , Singh Rakesh K. , Talmadge James E. , Muders Michael H. , Batra Surinder K. , Datta Kaustubh
Published: March 2023

Zymosan and apoptotic cell containing phagosome maturation in macrophages
Supplementary Figures S1-S8 from Transcription Factor YY1 Promotes Cell Proliferation by Directly Activating the Pentose Phosphate Pathway
Authors: Wu Shourong , Wang Huimin , Li Yanjun , Xie Yudan , Huang Can , Zhao Hezhao , Miyagishi Makoto , Kasim Vivi
Published: March 2023

Supplementary Figures S1-S8 - S1. Efficacies and specificities of shRNA expression vectors targeting YY1 and YY1 overexpression vector; S2. YY1 promotes antioxidant defense and enhances the production of PPP metabolites; S3. G6PD is critical for YY1 regulation on PPP; S4. YY1 regulates G6PD in a p53-independent manner; S5. YY1 regulates glucose metabolism in a p53-independent manner; S6. YY1 regulates PPP in a p53-independent manner; S7. YY1 affects PPP mainly by regulating G6PD; S8. Uncropped Western blots with the indicated areas of selection in Figs. 2, 5, 7, and Supplementary Figs. S1, S3 and S4.
Table S3 from Epigenetic Regulation of CXCL12 Plays a Critical Role in Mediating Tumor Progression and the Immune Response In Osteosarcoma
Authors: Li Binghao , Wang Zhan , Wu Hao , Xue Mingfeng , Lin Peng , Wang Shengdong , Lin Nong , Huang Xin , Pan Weibo , Liu Meng , Yan Xiaobo , Qu Hao , Sun Lingling , Li Hengyuan , Wu Yan , Teng Wangsiyuan , Wang Zenan , Zhou Xingzhi , Chen Huabiao , Poznansky Mark C. , Ye Zhaoming
Published: March 2023

Supplementary Table S3. Demographics of the included 332 osteosarcomas.
Table S1 from Inhibition of the Wnt/β-Catenin Pathway Overcomes Resistance to Enzalutamide in Castration-Resistant Prostate Cancer
Authors: Zhang Zhuangzhuang , Cheng Lijun , Li Jie , Farah Elia , Atallah Nadia M. , Pascuzzi Pete E. , Gupta Sanjay , Liu Xiaoqi
Published: March 2023

DEGs analysis in enzalutamide sensitive- (C4-2) and resistant- (C4-2R) PCa cell lines
Supplementary Figure S2 from HER2/EGFR–AKT Signaling Switches TGFβ from Inhibiting Cell Proliferation to Promoting Cell Migration in Breast Cancer
Authors: Huang Fei , Shi Qiaoni , Li Yuzhen , Xu Linlin , Xu Chi , Chen Fenfang , Wang Hai , Liao Hongwei , Chang Zai , Liu Fang , Zhang Xiang H.-F. , Feng Xin-Hua , Han Jing-Dong J. , Luo Shiwen , Chen Ye-Guang
Published: March 2023

HER2/EGFR signaling regulates the transcriptional activity of Smad3 but not Smad2
pub fee from Perspective on Circulating Tumor Cell Clusters: Why It Takes a Village to Metastasize
Authors: Giuliano Mario , Shaikh Anum , Lo Hin Ching , Arpino Grazia , De Placido Sabino , Zhang Xiang H. , Cristofanilli Massimo , Schiff Rachel , Trivedi Meghana V.
Published: March 2023

pub fee
Supplementary Data from Comprehensive Mutation and Copy Number Profiling in Archived Circulating Breast Cancer Tumor Cells Documents Heterogeneous Resistance Mechanisms
Authors: Paoletti Costanza , Cani Andi K. , Larios Jose M. , Hovelson Daniel H. , Aung Kimberly , Darga Elizabeth P. , Cannell Emily M. , Baratta Paul J. , Liu Chia-Jen , Chu David , Yazdani Maryam , Blevins Allen R. , Sero Valeria , Tokudome Nahomi , Thomas Dafydd G. , Gersch Christina , Schott Anne F. , Wu Yi-Mi , Lonigro Robert , Robinson Dan R. , Chinnaiyan Arul M. , Bischoff Farideh Z. , Johnson Michael D. , Park Ben H. , Hayes Daniel F. , Rae James M. , Tomlins Scott A.
Published: March 2023

Supplementary Figure S1. Clinical timelines. Clinical timelines and treatment from first diagnosis until enrollment into MI-CTC-ONCOSEQ for the 11 metastatic breast cancer patients; Supplementary Figure S2. Sanger sequencing of WGA CTC DNA and Western blot confirming the presence of A569S mutation; Supplementary Figure S3. MCF-7 (ESR1 A569S) are not estrogen independent over 5 days in hormone-free conditions; Supplementary Figure S4. The tamoxifen metabolites 4-hydroxytamoxifen and endoxifen have no increased agonistic effect in MCF-7 cells over-expressing ER-A569S; Supplementary Figure S5. Inhibition of estradiol-stimulated MCF-7 parental or A569S- overexpressing cells. Supplementary Table S1. Oncomine Comprehensive Panel (OCP) target genes by presence of the MseI restriction site; Table S2. NGS of BT-474 cells spiked into blood and purified identifies expectedTP53 mutation; Supplementary Table S3. Results of CTC purification by DEPArray; Supplementary Table S4: Mean CTC Next Generation Sequencing parameters; Supplementary Table S5. NGS-identified prioritized mutations in individual and pooled CTC samples; Supplementary Table S6. 2 x 2 contingency tables of concordance for alterations in CTC vs tissue; Supplementary Table S7. Patient #2 analysis of primary, clinical metastatic tissue, research biopsy, pt-DNA by ddPCR; Supplementary Table S8. Primer/probe sequences used in Sanger sequencing and ddPCR.
Supplementary Figure S5 from Interleukin-30/IL27p28 Shapes Prostate Cancer Stem-like Cell Behavior and Is Critical for Tumor Onset and Metastasization
Authors: Sorrentino Carlo , Ciummo Stefania L. , Cipollone Giuseppe , Caputo Sara , Bellone Matteo , Di Carlo Emma
Published: March 2023

Immunohistochemical analyses of EBI3 expression in subcutaneously developed PIN-SC tumors in comparison with PIN-SC orthotopic tumors. Scale bars: 30 micron.
Figure S2 from The miR-371∼373 Cluster Represses Colon Cancer Initiation and Metastatic Colonization by Inhibiting the TGFBR2/ID1 Signaling Axis
Authors: Ullmann Pit , Rodriguez Fabien , Schmitz Martine , Meurer Steffen K. , Qureshi-Baig Komal , Felten Paul , Ginolhac Aurélien , Antunes Laurent , Frasquilho Sonia , Zügel Nikolaus , Weiskirchen Ralf , Haan Serge , Letellier Elisabeth
Published: March 2023

Short hairpin (sh) RNA knockdown control of TGFBR2
Figure S3 from Metabolic and Physiologic Imaging Biomarkers of the Tumor Microenvironment Predict Treatment Outcome with Radiation or a Hypoxia-Activated Prodrug in Mice
Authors: Matsumoto Shingo , Kishimoto Shun , Saito Keita , Takakusagi Yoichi , Munasinghe Jeeva P. , Devasahayam Nallathamby , Hart Charles P. , Gillies Robert J. , Mitchell James B. , Krishna Murali C.
Published: March 2023

Plots of tumor growth delay vs HF10; pO2; lac/pyr
Table S1 from RNF6 Promotes Colorectal Cancer by Activating the Wnt/β-Catenin Pathway via Ubiquitination of TLE3
Authors: Liu Lei , Zhang Yanquan , Wong Chi Chun , Zhang Jingwan , Dong Yujuan , Li Xiangchun , Kang Wei , Chan Francis K.L. , Sung Joseph J.Y. , Yu Jun
Published: March 2023

Clinicopathological features of CRC patients
Figure S7 from High USP6NL Levels in Breast Cancer Sustain Chronic AKT Phosphorylation and GLUT1 Stability Fueling Aerobic Glycolysis
Authors: Avanzato Daniele , Pupo Emanuela , Ducano Nadia , Isella Claudio , Bertalot Giovanni , Luise Chiara , Pece Salvatore , Bruna Alejandra , Rueda Oscar M. , Caldas Carlos , Di Fiore Pier Paolo , Sapino Anna , Lanzetti Letizia
Published: March 2023

Sensitivity to MK2206 in the USP6NL-high and -low cell lines
Figure S6 from High USP6NL Levels in Breast Cancer Sustain Chronic AKT Phosphorylation and GLUT1 Stability Fueling Aerobic Glycolysis
Authors: Avanzato Daniele , Pupo Emanuela , Ducano Nadia , Isella Claudio , Bertalot Giovanni , Luise Chiara , Pece Salvatore , Bruna Alejandra , Rueda Oscar M. , Caldas Carlos , Di Fiore Pier Paolo , Sapino Anna , Lanzetti Letizia
Published: March 2023

USP6NL overexpression increases AKT phosphorylation
Figure S2 from High USP6NL Levels in Breast Cancer Sustain Chronic AKT Phosphorylation and GLUT1 Stability Fueling Aerobic Glycolysis
Authors: Avanzato Daniele , Pupo Emanuela , Ducano Nadia , Isella Claudio , Bertalot Giovanni , Luise Chiara , Pece Salvatore , Bruna Alejandra , Rueda Oscar M. , Caldas Carlos , Di Fiore Pier Paolo , Sapino Anna , Lanzetti Letizia
Published: March 2023

USP6NL silencing by three oligos impairs proliferation and AKT phosphorylation
Supplementary Table S5 from UBE2N Promotes Melanoma Growth via MEK/FRA1/SOX10 Signaling
Authors: Dikshit Anushka , Jin Yingai J. , Degan Simone , Hwang Jihwan , Foster Matthew W. , Li Chuan-Yuan , Zhang Jennifer Y.
Published: March 2023

Supplementary Table S5. UBE2N loss resulted in distinct alterations to the signaling landscape, as revealed by Mass spectrometry-based phosphoproteomic analysis
Supplementary Table S2 from Network Modeling of microRNA–mRNA Interactions in Neuroblastoma Tumorigenesis Identifies miR-204 as a Direct Inhibitor of MYCN
Authors: Ooi Chi Yan , Carter Daniel R. , Liu Bing , Mayoh Chelsea , Beckers Anneleen , Lalwani Amit , Nagy Zsuzsanna , De Brouwer Sara , Decaesteker Bieke , Hung Tzong-Tyng , Norris Murray D. , Haber Michelle , Liu Tao , De Preter Katleen , Speleman Frank , Cheung Belamy B. , Marshall Glenn M.
Published: March 2023

Supplementary Table 2-1 All miRNA-mRNA interactions detected for network presented in Figure 2A, Supplementary Table 2-2 Expression of miRNAs in human adrenal neuroblasts and MYCN-amplified tumours
Figure S4 from The Small GTPase ARF6 Activates PI3K in Melanoma to Induce a Prometastatic State
Authors: Yoo Jae Hyuk , Brady Samuel W. , Acosta-Alvarez Lehi , Rogers Aaron , Peng Jingfu , Sorensen Lise K. , Wolff Roger K. , Mleynek Tara , Shin Donghan , Rich Coulson P. , Kircher David A. , Bild Andrea , Odelberg Shannon J. , Li Dean Y. , Holmen Sheri L. , Grossmann Allie H.
Published: March 2023

Figure S4. Primary tumor incidence, growth, survival and metastasis in Ptenf/f vs. Arf6Q67L mice. (a) Increased tumor incidence (% = # of mice that developed a tumor / # TVA positive, injected mice) in Ptenf/f vs. Arf6Q67L cohorts. Fisher's exact test, two-tailed, α <0.05. (b) Primary tumor onset, unpaired t test with Welch's correction. (c) Primary tumor growth in Ptenf/f vs. Arf6Q67L mice upon tumor onset. Bars = SD. Two-way ANOVA, a=0.05. (d) Overall survival upon tumor onset, log-rank (Mantel-Cox) test. (e) Comparison of spontaneous metastatic volume in each mouse cohort (see also schematic, Figure 1g). ANOVA (p < 0.0001) with Kruskal-Wallis multiple comparisons test (p values shown). ns=not significant. Identical data from the Control and Arf6Q67L cohorts are also shown in Figure 1c with a slightly different Y axis spacing.
Video S1 from The Cancer Editome Atlas: A Resource for Exploratory Analysis of the Adenosine-to-Inosine RNA Editome in Cancer
Authors: Lin Chui-Hsien , Chen Sean Chun-Chang
Published: March 2023

Tutorial on the EdSite module
Supplementary Data from NOTCH Signaling via WNT Regulates the Proliferation of Alternative, CCR2-Independent Tumor-Associated Macrophages in Hepatocellular Carcinoma
Authors: Ye Yu-Chen , Zhao Jun-Long , Lu Yi-Tong , Gao Chun-Chen , Yang Yang , Liang Shi-Qian , Lu Ying-Ying , Wang Lin , Yue Shu-Qiang , Dou Ke-Feng , Qin Hong-Yan , Han Hua
Published: March 2023

Figure S1: Experimental design, Figure S2: LyzM-Cre-mediated RBPj cKO suppressed the growth of subcutaneous LLC tumors, Figure S3: LyzM-Cre-mediated RBPj cKO promoted the growth of orthotopic HCC tumors, Figure S4: kclTAMs dominated TAM populations promoting HCC growth, Figure S5: RBPj cKO led to increased proliferation of kclTAMs without influencing apoptosis in hepatic Hepa1-6 tumors, Figure S6: RBPj cKO did not affect the proliferation capacity of monocytes in vitro, Figure S7: RBPj cKO promoted the growth of hepatic Hepa1-6 tumors independent of CCR2,Figure S8: Notch signaling negatively regulated the activation of Wnt/β-catenin signaling and the proliferation of kclTAMs, Figure S9: Blocking Wnt signaling inhibited the growth of hepatic Hepa1-6 tumors, Figure S10: Knockdown of β-catenin repressed the proliferation of RBPj-deficient KCs, Figure S11: RBPj cKO promoted kclTAM proliferation and hepatic tumor growth through β-catenin-dependent Wnt signaling, Figure S12: RBPj cKO promoted the hepatic metastasis but suppressed lung metastasis, Figure S13: A model depicting the role of Notch signaling in TAM subsets regulating hepatic tumor growth and metastasis in liver, Table S1: Clinical data of 44 HCC patients involved in this study, Table S2: Antibodies used in this study, Table S3: Primers and oligonucleotides used in this study
Supplementary Figures from Polyol Pathway Links Glucose Metabolism to the Aggressiveness of Cancer Cells
Authors: Schwab Annemarie , Siddiqui Aarif , Vazakidou Maria Eleni , Napoli Francesca , Böttcher Martin , Menchicchi Bianca , Raza Umar , Saatci Özge , Krebs Angela M. , Ferrazzi Fulvia , Rapa Ida , Dettmer-Wilde Katja , Waldner Maximilian J. , Ekici Arif B. , Rasheed Suhail Ahmed Kabeer , Mougiakakos Dimitrios , Oefner Peter J. , Sahin Ozgur , Volante Marco , Greten Florian R. , Brabletz Thomas , Ceppi Paolo
Published: March 2023

SUPPLEMENTARY FIGURE 1 Correlation of VIM/CDH1 ratios in different datasets. The list of 35 genes significantly correlated with EMT. Lack of correlation between AKR1B10 mRNA levels and EMT. SUPPLEMENTARY FIGURE 2 AKR1B1 levels are modulated by ZEB1, but not in a direct fashion. SUPPLEMENTARY FIGURE 3 Characteristics of the NSCLC patients stained with immunohistochemistry and impact on survival. Alterations of AKR1B1 levels influence cancer cells growth and cancer stemness. SUPPLEMENTARY FIGURE 4 Impact of SORD knockdown on cancer cells growth and invasion. The combination of the inhibition of polyol pathway gene and cisplatin suppresses in vitro growth. Oxidative consumption rate and ECAR/OCR ratios in polyol pathway-deficient cells. SUPPLEMENTARY FIGURE 5 Co-expression patterns of AKR1B1 and SORD in TCGA datasets. SUPPLEMENTARY FIGURE 6 Effects of treatment with excess glucose on the generation of polyols, on the alteration of EMT and stemness markers, and on the activation of TGF-Beta signaling and TGF-Beta-related genes.
Supplementary Figure2 from Temozolomide Induces Senescence and Repression of DNA Repair Pathways in Glioblastoma Cells via Activation of ATR–CHK1, p21, and NF-κB
Authors: Aasland Dorthe , Götzinger Laura , Hauck Laura , Berte Nancy , Meyer Jessica , Effenberger Melanie , Schneider Simon , Reuber Emelie E. , Roos Wynand P. , Tomicic Maja T. , Kaina Bernd , Christmann Markus
Published: March 2023

Cell death in p53 deficient cells, efficiency of p21 knockdown and expression of CDK1/CyklinB1
Supplementary Data from Targeting BCR-ABL1 in Chronic Myeloid Leukemia by PROTAC-Mediated Targeted Protein Degradation
Authors: Burslem George M. , Schultz Anna Reister , Bondeson Daniel P. , Eide Christopher A. , Savage Stevens Samantha L. , Druker Brian J. , Crews Craig M.
Published: March 2023

Supplemental Figures and Tables. Figure S1 - Immunoblotting characterization of GMB-101 and GMB-475. Figure S2 - Validation of degradation and compound toxicity via comparison of GMB-475 and GMB-651. Figure S3 - Combinations of ATP competitive TKIs with PROTAC. Figure S4 - Schematic of scaffolding roles, VHL ligand and imatinib controls for VHL and pGAB2. Figure S5 - Patient sample sorting workflow and additional patient samples. Table S2 - Patient characteristics for primary samples
Supplementary Data from Targeting BCR-ABL1 in Chronic Myeloid Leukemia by PROTAC-Mediated Targeted Protein Degradation
Authors: Burslem George M. , Schultz Anna Reister , Bondeson Daniel P. , Eide Christopher A. , Savage Stevens Samantha L. , Druker Brian J. , Crews Craig M.
Published: March 2023

Synthetic procedures and characterization for the preparation of compounds used within this study.
Figure S3 from Remodeling the Tumor Microenvironment Sensitizes Breast Tumors to Anti-Programmed Death-Ligand 1 Immunotherapy
Authors: Clift Renee , Souratha Jennifer , Garrovillo Sheryl A. , Zimmerman Susan , Blouw Barbara
Published: March 2023

Pegvorhyaluronidase alfa increased density of T-cells and NK cells and decreased the proportion of Gr1+ myeloid-derived suppressor cells in 4T1/HAS3 orthotopic breast tumors
Supplementary Data from A Direct Podocalyxin–Dynamin-2 Interaction Regulates Cytoskeletal Dynamics to Promote Migration and Metastasis in Pancreatic Cancer Cells
Authors: Wong Bin Sheng , Shea Daniel J. , Mistriotis Panagiotis , Tuntithavornwat Soontorn , Law Robert A. , Bieber Jake M. , Zheng Lei , Konstantopoulos Konstantinos
Published: March 2023

Contains Supplementary Figures, Supplementary Figure Legends, Supplementary Video Legends, Supplementary Table and Supplementary Methods
Supplementary Figure 3 from Volumetric Optoacoustic Imaging Unveils High-Resolution Patterns of Acute and Cyclic Hypoxia in a Murine Model of Breast Cancer
Authors: Ron Avihai , Deán-Ben Xosé Luís , Gottschalk Sven , Razansky Daniel
Published: March 2023

Figure S3 shows local oxygen saturation responses to a dynamic oxygen challenge in the different animals (n=6).
Supplementary Figure 2 from Volumetric Optoacoustic Imaging Unveils High-Resolution Patterns of Acute and Cyclic Hypoxia in a Murine Model of Breast Cancer
Authors: Ron Avihai , Deán-Ben Xosé Luís , Gottschalk Sven , Razansky Daniel
Published: March 2023

Figure S2 shows average oxygen saturation responses to a dynamic oxygen challenge for three different tumors.
Table S1 from Use of a Single CAR T Cell and Several Bispecific Adapters Facilitates Eradication of Multiple Antigenically Different Solid Tumors
Authors: Lee Yong Gu , Marks Isaac , Srinivasarao Madduri , Kanduluru Ananda Kumar , Mahalingam Sakkarapalayam M. , Liu Xin , Chu Haiyan , Low Philip S.
Published: March 2023

Conversion of CAM units from nmole/kg to mg/kg
Figure S2 from Use of a Single CAR T Cell and Several Bispecific Adapters Facilitates Eradication of Multiple Antigenically Different Solid Tumors
Authors: Lee Yong Gu , Marks Isaac , Srinivasarao Madduri , Kanduluru Ananda Kumar , Mahalingam Sakkarapalayam M. , Liu Xin , Chu Haiyan , Low Philip S.
Published: March 2023

Evaluation of the requirement for a tumor antigen-matched CAM to mediate tumor elimination
Supplementary Table 1 from Molecular Profiling Establishes Genetic Features Predictive of the Efficacy of the p110β Inhibitor KIN-193
Authors: Sethi Isha , Cai Zhenying , Roberts Thomas M. , Yuan Guo-Cheng
Published: March 2023

A. 67 PTEN-null cell-lines from GDSC. Columns 1:4 contain serial number, Cell-line identifier, KIN-193 Zscore and KIN-193 ID (S: Sensitive; R: Resistance) respectively. B. Association score of 5143 features with KIN-193 efficacy. Negative RNMI score implies strong association with resistance, positive RNMI core implies strong association with sensitivity. Columns 1:3 contain Gene name which is mutated, RNMI score and status in COSMIC database as cancer gene.
Supplementary Tables from CXADR-Mediated Formation of an AKT Inhibitory Signalosome at Tight Junctions Controls Epithelial–Mesenchymal Plasticity in Breast Cancer
Authors: Nilchian Azadeh , Johansson Joel , Ghalali Aram , Asanin Sandra T. , Santiago Ana , Rosencrantz Oskar , Sollerbrant Kerstin , Vincent C. Theresa , Sund Malin , Stenius Ulla , Fuxe Jonas
Published: March 2023

This supplementary information includes 3 supplementary tables. Table S1. List of antibodies. Table S2. List of plasmids. Table S3. List of human tumor samples.
Supplementary Figure S4 from Deletion of Calcineurin Promotes a Protumorigenic Fibroblast Phenotype
Authors: Lieberman Allyson , Barrett Richard , Kim Jaewon , Zhang Kathy L. , Avery Diana , Monslow James , Kim Hyunsoo , Kim Bang-Jin , Puré Ellen , Ryeom Sandra
Published: March 2023

Effects of caNFATc1 expression in CN-/- fibroblasts on migration.
Figure S6 from Upregulation of PD-L1 via HMGB1-Activated IRF3 and NF-κB Contributes to UV Radiation-Induced Immune Suppression
Authors: Wang Wei , Chapman Nicole M. , Zhang Bo , Li Mingqi , Fan Meiyun , Laribee R. Nicholas , Zaidi M. Raza , Pfeffer Lawrence M. , Chi Hongbo , Wu Zhao-Hui
Published: March 2023

UVR-promoted melanoma evasion from CTL cytotoxicity, in an IRF3-dependent manner, was mitigated by blocking PD-1/PD-L1.
Figure S4 from Glucocorticoid Receptor Signaling Activates TEAD4 to Promote Breast Cancer Progression
Authors: He Lingli , Yuan Liang , Sun Yang , Wang Pingyang , Zhang Hailin , Feng Xue , Wang Zuoyun , Zhang Wenxiang , Yang Chuanyu , Zeng Yi Arial , Zhao Yun , Chen Ceshi , Zhang Lei
Published: March 2023

Supplementary Figure 4. GR together with TEAD4 is recruited to the TEAD4 promoter region to promote TEAD4 transcription.
Supplementary Data from IL12 Abrogates Calcineurin-Dependent Immune Evasion during Leukemia Progression
Authors: Rabe Jennifer L. , Gardner Lori , Hunter Rae , Fonseca Jairo A. , Dougan Jodi , Gearheart Christy M. , Leibowitz Michael S. , Lee-Miller Cathy , Baturin Dmitry , Fosmire Susan P. , Zelasko Susan E. , Jones Courtney L. , Slansky Jill E. , Rupji Manali , Dwivedi Bhakti , Henry Curtis J. , Porter Christopher C.
Published: March 2023

Supplemental Table 2: Pathways analysis of RNA-seq using DAVID.
Figure S5 from Bortezomib Stabilizes and Activates p53 in Proliferative Compartments of Both Normal and Tumor Tissues In Vivo
Authors: Xue Yuezhen , Barker Nick , Hoon Shawn , He Pingping , Thakur Teena , Abdeen Shifana Raja , Maruthappan Priadarsini , Ghadessy Farid J. , Lane David P.
Published: March 2023

Stabilized p53 colocalizes with cycling and proliferating proteins in intestinal adenomas.
Figure S4 from Bortezomib Stabilizes and Activates p53 in Proliferative Compartments of Both Normal and Tumor Tissues In Vivo
Authors: Xue Yuezhen , Barker Nick , Hoon Shawn , He Pingping , Thakur Teena , Abdeen Shifana Raja , Maruthappan Priadarsini , Ghadessy Farid J. , Lane David P.
Published: March 2023

Stabilized p53 colocalizes with PCNA in the stomach and colon.
Supplementary Movie 2 from Gene Editing of α6 Integrin Inhibits Muscle Invasive Networks and Increases Cell–Cell Biophysical Properties in Prostate Cancer
Authors: Rubenstein Cynthia S. , Gard Jaime M.C. , Wang Mengdie , McGrath Julie E. , Ingabire Nadia , Hinton James P. , Marr Kendra D. , Simpson Skyler J. , Nagle Raymond B. , Miranti Cindy K. , Warfel Noel A. , Garcia Joe G.N. , Arif-Tiwari Hina , Cress Anne E.
Published: March 2023

Invasive Network formation in DU145 α6AA cells
Supplementary Figure 5 from Gene Editing of α6 Integrin Inhibits Muscle Invasive Networks and Increases Cell–Cell Biophysical Properties in Prostate Cancer
Authors: Rubenstein Cynthia S. , Gard Jaime M.C. , Wang Mengdie , McGrath Julie E. , Ingabire Nadia , Hinton James P. , Marr Kendra D. , Simpson Skyler J. , Nagle Raymond B. , Miranti Cindy K. , Warfel Noel A. , Garcia Joe G.N. , Arif-Tiwari Hina , Cress Anne E.
Published: March 2023

Pancreas invasion is independent of integrin α6 status
Supplementary Figure S6 from Chromosome 12p Amplification in Triple-Negative/BRCA1-Mutated Breast Cancer Associates with Emergence of Docetaxel Resistance and Carboplatin Sensitivity
Authors: Gómez-Miragaya Jorge , Díaz-Navarro Ander , Tonda Raul , Beltran Sergi , Palomero Luis , Palafox Marta , Dobrolecki Lacey E. , Huang Chen , Vasaikar Suhas , Zhang Bing , Wulf Gerburg M. , Collado-Sole Alejandro , Trinidad Eva M. , Muñoz Purificación , Paré Laia , Prat Aleix , Bruna Alejandra , Caldas Carlos , Arribas Joaquín , Soler-Monso María Teresa , Petit Anna , Balmaña Judith , Cruz Cristina , Serra Violeta , Pujana Miguel Angel , Lewis Michael T. , Puente Xose S. , González-Suárez Eva
Published: March 2023

Docetaxel response on TNBC cell lines with ETV6 and GABARAPL1 overexpression and knockdown
Supplemental Figure 2 from Stearoyl-CoA Desaturase 1 Protects Ovarian Cancer Cells from Ferroptotic Cell Death
Authors: Tesfay Lia , Paul Bibbin T. , Konstorum Anna , Deng Zhiyong , Cox Anderson O. , Lee Jingyun , Furdui Cristina M. , Hegde Poornima , Torti Frank M. , Torti Suzy V.
Published: March 2023

Sensitivity of FT-t and FT-I cells to SCD1 inhibitors
Supplementary Figure 3 from Landscape of Germline and Somatic Mitochondrial DNA Mutations in Pediatric Malignancies
Authors: Triska Petr , Kaneva Kristiyana , Merkurjev Daria , Sohail Noor , Falk Marni J. , Triche Timothy J. , Biegel Jaclyn A. , Gai Xiaowu
Published: March 2023

Supplementary Figure 3 illustrates how the observed dN/dS ratio varies by the heteroplasmy.
Supplementary Data from CML Hematopoietic Stem Cells Expressing IL1RAP Can Be Targeted by Chimeric Antigen Receptor–Engineered T Cells
Authors: Warda Walid , Larosa Fabrice , Neto Da Rocha Mathieu , Trad Rim , Deconinck Eric , Fajloun Ziad , Faure Cyril , Caillot Denis , Moldovan Marius , Valmary-Degano Severine , Biichle Sabeha , Daguindau Etienne , Garnache-Ottou Francine , Tabruyn Sebastien , Adotevi Olivier , Deschamps Marina , Ferrand Christophe
Published: March 2023

Additonnal data (Material & Method)
Supplementary Table S4 from YES1 Is a Targetable Oncogene in Cancers Harboring YES1 Gene Amplification
Authors: Hamanaka Natsuki , Nakanishi Yoshito , Mizuno Takakazu , Horiguchi-Takei Kana , Akiyama Nukinori , Tanimura Hiromi , Hasegawa Masami , Satoh Yasuko , Tachibana Yukako , Fujii Toshihiko , Sakata Kiyoaki , Ogasawara Kiyomoto , Ebiike Hirosato , Koyano Hiroshi , Sato Haruhiko , Ishii Nobuya , Mio Toshiyuki
Published: March 2023

Anti-proliferative activity against KYSE70 expressing mock, YES1-WT and SRC-WT