bluuebunny/crossref_metadata_2025 huggingface dataset:
What does legacy mean to people making treatment choices for serious illness? A scoping review protocol (Preprint)
Authors: Figueroa Gray Marlaine , Banegas Mateo , Henrikson Nora
Published: July 2022

BACKGROUND

Legacy – what one leaves behind and how one hopes to be remembered after death—is an unexplored and important dimension of decision-making for people facing serious illness. To date, very little is known about the conceptual foundations of legacy. No conceptual frameworks exist that provide comprehensive understanding of how legacy considerations relate to patient choices about their medical care.

OBJECTIVE

The objective of this scoping review is to understand the extent and type of research addressing the concept of legacy by people facing serious illness to inform a conceptual framework of legacy and patient treatment choices.

METHODS

This protocol follows the guidelines put forth by Levac et al, which expands the framework introduced by Arksey and O’Malley, as well as the Joanna Briggs Institute Reviewer’s manual. This scoping review explores several electronic databases including PubMed, Medline, CINAHL, Cochrane Library, PsycINFO and others and includes legacy-specific grey literature. An initial search will be conducted in English-language literature from 2000-present with selected keywords to identify relevant articles and refine the search strategy. After the search strategy has been finalized, two independent reviewers will undertake a 2-part study selection process. In the first step, reviewers will screen article titles and abstracts to identify the eligibility of each article based on pre-determined exclusion/inclusion criteria. A third senior reviewer will arbitrate discrepancies regarding inclusions/exclusions. During the second step, the full texts will be screened and only relevant articles will be kept. Relevant study data will be extracted, collated, and charted to summarize the key findings related to the construct of legacy.

RESULTS

This study will identify how people facing serious illness define legacy, and how their thinking about legacy impacts the choices they make about their medical treatments. The findings of this study will inform a conceptual model that outlines how ideas about legacy impact treatment choices. The results of this study will be submitted to an indexed journal.

CONCLUSIONS

Very little is known about the role of legacy in treatment decisions of patients across the continuum of serious illness. In particular, no comprehensive conceptual model exists that would provide understanding of how legacy is considered by people making decisions about their care during serious illness. This study will be the first to construct a conceptual model detailing how considerations of legacy impact medical decision making for people facing or living with serious illness.
Removal of Uremic Solutes from Dialysate by Activated Carbon
Authors: Lee Seolhyun , Sirich Tammy L. , Blanco Ignacio J. , Plummer Natalie S. , Meyer Timothy W.
Published: July 2022

Background and objectives

Adsorption of uremic solutes to activated carbon provides a potential means to limit dialysate volumes required for new dialysis systems. The ability of activated carbon to take up uremic solutes has, however, not been adequately assessed.

Design, setting, participants, & measurements

Graded volumes of waste dialysate collected from clinical hemodialysis treatments were passed through activated carbon blocks. Metabolomic analysis assessed the adsorption by activated carbon of a wide range of uremic solutes. Additional experiments tested the ability of the activated carbon to increase the clearance of selected solutes at low dialysate flow rates.

Results

Activated carbon initially adsorbed the majority, but not all, of 264 uremic solutes examined. Solute adsorption fell, however, as increasing volumes of dialysate were processed. Moreover, activated carbon added some uremic solutes to the dialysate, including methylguanidine. Activated carbon was particularly effective in adsorbing uremic solutes that bind to plasma proteins. In vitro dialysis experiments showed that introduction of activated carbon into the dialysate stream increased the clearance of the protein-bound solutes indoxyl sulfate and p-cresol sulfate by 77%±12% (mean±SD) and 73%±12%, respectively, at a dialysate flow rate of 200 ml/min, but had a much lesser effect on the clearance of the unbound solute phenylacetylglutamine.

Conclusions

Activated carbon adsorbs many but not all uremic solutes. Introduction of activated carbon into the dialysate stream increased the clearance of those solutes that it does adsorb.
An Optimistic Exploration of the Essential Transcendence of Man Potentiated in The Last Man
Authors: Guijun Li , Jun Luo
Published: July 2022

The science fiction of Mary Shelly has engendered an increasing attention of an increasing number of literary scholars in their meticulous and miraculous exploration of the ideological and epistemological values in which the cautious and conductive production of this science fiction titled The Last Man (1826) has been interwoven in the very pessimistic narrative facts and narrative events to crop up in 2073 an incredible fashion. A good look taken at the analytical findings of a good many scholars who have been devoted to the studies of this science fiction, it will be found in an apparent way that they have done a lot in the discussions about the themes, narrations, as well as, languages of this science fiction, the minds of the characters as have been depicted in this science fiction, and, the artistic thoughts of it from various perspectives while a little in the essential explorations of the true transcendence of man as indebted to what has been mirrored in it. For the sake of the inadequate elaboration in this regard, this article will aim to make an exploration of how the evolution, promotion, and, liberation of man as focused on the enrichment and improvement of the theoretical frameworks and theoretical systems of legal naturalism have a great impact on the stimulation and promotion of the essential transcendence of the views, values, and, virtues of man in line with what has been exemplified in this science fiction to make it clear that this science fiction has shed some impressive lights in the successful and sufficient achievement of this transcendence in the future.
DIJALOG IZMEĐU RELIGIJA: REALNA MOGUĆNOST ILI PUSTA ŽELJA?
Authors: Bakić-Hejden Milica
Published: July 2022

U radu se razmatraju mogućnosti dijaloga između religija s obzirom na njihovo autoritativno i apsolutno tumačenja sveta, te sukobima opterećenu prošlost. Kratak istorijski osvrt na neke oblike dijaloga između religija pokazuje na teorijskom (doktrinarnom) nivou neprikosnovenost granica koje ih dele. U ’praksi’ se, međutim, pokazuje da te granice mogu biti porozne, što je ilustrovano primerima svetaca sa dvojnim identitetom odnosno svetilišta koja pohode hodočasnici različitih religija čime, indirektno, ostajući u okvirima svog religijskog identiteta, samim svojim prisustvom na svetom mestu religijskog drugog vode neku vrstu (neverbalnog) ’dijaloga’. Da li onda i drugi oblici religijske prakse mogu naći mesto u međureligijskom dijalogu? Ne umanjujući realnost istorijskih okolnosti koje su definisale često negativne odnose između religija, promenom naglaska sa spoljašnjih na unutrašnje veze između religijskih tradicija zasnovanih na iskustvenom aspektu vere, bilo kroz obrede (kao u navedenim primerima) ili kroz razmenu iskustava u molitvenoj i kontemplativnoj praksi, moglo bi se postići bolje razumevanje religijskog Drugog.
Disease Prediction and Diagnosis Using Machine Learning
Authors: v Srilakshmi , V Prathima
Published: July 2022

Abstract: With big data growth in biomedical and healthcare communities, accurate analysis of medical data benefits early disease detection, patient care, and community services. However, the analysis accuracy is reduced when the quality of medical data is incomplete. Moreover, differentregions exhibit unique characteristics of certain regional diseases, which may weaken the prediction of disease outbreaks. Healthcare is very important to lead a good life. However, it is very difficult to obtain the consultation with the doctor for every health problem. The idea is to create a medical Chatbot using Artificial Intelligence that can diagnose the disease and provide basic details about the disease before consulting a doctor. This will help to reduce healthcare costs and improve accessibility to medical knowledge through medical Chatbot. The chatbots are computer programs that use natural language to interact with users. The Chatbot stores the data in the database to identify the sentence keywords and to make a query decision and answer the question
Brain Tumour Classification and Identification Using Deep Learning Neural Networks
Authors: R Miss. Manasa , Malge Mrs. Renuka
Published: July 2022

Abstract: Convolutional Neural Network (CNN)-based brain tumour detection is used to identify and categorise different types of tumours. Many scholars have studied and designed paths across this area over the course of many years. We've suggested a method that can identify and categorise various tumour forms. Since MRI scans the human brain without requiring any operations, they provide a comprehensive picture of the human brain's anatomy, which aids in the processing of the image for tumour identification. Misclassification results from human beings predicting tumours from MRI pictures. This inspires us to create the algorithm for brain tumour identification. For the purpose of identifying tumours, machine learning is helpful and important. Convolutional neural networks (CNNs), one of the machine learning algorithms, was used in this article because of their strength in image processing. Using CNNs and MRI data, we created a web application for the identification of brain tumours and the classification of their various forms, this web application contains about disease, treatments and famous doctors for treat this disease.
Determinan Kinerja Manajerial Pemerintah Desa Di Kabupaten Bantul
Authors: Sofyani Hafiez , Ardiyanto Irfan
Published: July 2022

This study aims to empirically examine the effect of management commitment, budgetary participation, and internal control systems implementation on the managerial performance of the village government. The population of this study were all villages in Bantul Regency in which 32 villages were selected as samples. The sampling technique uses the convenience sampling. Research data in the form of primary data obtained by distributing questionnaires directly to respondents. The data analysis technique employs multiple linear regression. The classical assumption test on the research data has been carried out prior to hypothesis testing. The results show that there are no classical assumption problems in the research data, so that hypothesis testing can be carried out. The results show that management commitment, budgetary participation, and internal control system implementation positively influence the managerial performance of the village government. The results of this study provide practical implications that are significant to consider for village governments to improve their managerial performance.
Analisis Nilai Relevansi Pengungkapan Corporate Social Responsibility Dengan Diversitas Direksi Sebagai Variabel Moderasi
Authors: Wulan Diajeng Fitri , Lindrianasari Lindrianasari , Amelia Yunia , Gamayuni Rindu Rika
Published: July 2022

This study aims to see the value relevance ​​of CSR Disclosure. The object of this research is all companies listed on the IDX in 2020 which publish an annual report with 352 observation companies. The data used is taken from the company’s annual report by using purposive sampling. This study examines the effect of CSR Disclosure on value relevance with board diversity (gender, age, and education) as the moderating variable. By using statistical descriptive tests and regression analysis, it is ensured that CSR Disclosure does not affect the value of relevance, meaning that it does not affect the reactions and considerations of investors’ decisions. The moderating variable also cannot provide a significant influence on CSR Disclosure and its effect on the value relevance. This is because of investors’ considerations that are still focused on the company’s financial performance compared to the company’s non-financial performance companies. The contribution of this research can be used as reference in decisions and policies in the company’s annual reporting to influence market reactions to information disclosure. In addition, it can also be used as a reference for the regulators to pay more attention to the CSR disclosure of the companies to be more thorough.
Pajak Daerah, Lain-Lain PAD yang Sah, dan Belanja Modal: Bukti Empiris Provinsi Sumatera Selatan
Authors: Martini Rita , Lorensa Lesy , Amri Darul
Published: July 2022

This study aims to investigate the impact of local taxes and other legal municipal revenue on capital expenditures. The research population includes seventeen regencies/cities in the province of South Sumatra from 2015- 2019. Using the purposive sampling method, ten districts/cities were chosen as research samples. The Directorate General of Fiscal Balance (DJPK) website provided secondary data for Regency/City Budget Realization Reports. Multiple regression was employed in the data analysis, which was done with the SPSS program. The findings of the study show that local taxes have a significant impact on capital expenditures, other legitimate regional original income has a significant impact on capital expenditures, and both local taxes and other legitimate regional original income influence capital expenditures at the same time. According to this report, district/city governments in South Sumatra should improve regional income even more. Expanding economic streams and establishing self-sufficiency are required to achieve independence.
Naturally restricted subsets of nonsignaling correlations: typicality and convergence
Authors: Lin Pei-Sheng , Vértesi Tamás , Liang Yeong-Cherng
Published: July 2022

It is well-known that in a Bell experiment, the observed correlation between measurement outcomes – as predicted by quantum theory – can be stronger than that allowed by local causality, yet not fully constrained by the principle of relativistic causality. In practice, the characterization of the set Q of quantum correlations is carried out, often, through a converging hierarchy of outer approximations. On the other hand, some subsets of Q arising from additional constraints [e.g., originating from quantum states having positive-partial-transposition (PPT) or being finite-dimensional maximally entangled (MES)] turn out to be also amenable to similar numerical characterizations. How, then, at a quantitative level, are all these naturally restricted subsets of nonsignaling correlations different? Here, we consider several bipartite Bell scenarios and numerically estimate their volume relative to that of the set of nonsignaling correlations. Within the number of cases investigated, we have observed that (1) for a given number of inputs ns (outputs no), the relative volume of both the Bell-local set and the quantum set increases (decreases) rapidly with increasing no (ns) (2) although the so-called macroscopically local set Q1 may approximate Q well in the two-input scenarios, it can be a very poor approximation of the quantum set when ns>no (3) the almost-quantum set Q~1 is an exceptionally-good approximation to the quantum set (4) the difference between Q and the set of correlations originating from MES is most significant when no=2, whereas (5) the difference between the Bell-local set and the PPT set generally becomes more significant with increasing no. This last comparison, in particular, allows us to identify Bell scenarios where there is little hope of realizing the Bell violation by PPT states and those that deserve further exploration.
Las sirenas y el inquisidor
Authors: Fernández Vega Juan Luis , de Unamuno y Jugo Miguel
Published: July 2022

The final stretch in the lifetime of the Basque philosopher and writer Miguel de Unamuno was marked by the loss of some of his most loved ones (wife, first-born daughter, siblings) and by the deterioration of the experience of the Second Spanish Republic, which led in 1936 to the civil war. These two painful processes, the personal and the sociological, are mirrored by his political analyses in newspaper articles, by his poetic expression, and by his philosophical reflections on his own work or that of others. Thus, together with the feeling of love and nostalgia, Unamuno examines the internal constitution of Spain, elaborates a theory of history, explores the profound meaning of catholicity and revolution, and tries to renew classical liberalism, in a Spanish and hispanizing national-liberal spirit. Faced with the growing ideological polarization within the Republic, Unamuno bets on "alterutrality": being in the middle holding the extremes, preventing one Spain from considering the other as anti-Spain. At the same time, the meditation about the myth of Don Juan in his 1934 drama drove Unamuno, who read and commented on this work at the Santander International Summer University, to a final reworking of his philosophy of existence as "representation". This book presents a selection of political articles, poems, and literary prologues written by Unamuno between 1931 and 1935, and it includes an introductory essay contextualizing his late thought.
Impacts of work attitude of outsourcing services on food losses: evidence from rice harvest in China
Authors: Qu Xue , Kojima Daizo , Wu Laping , Ando Mitsuyoshi
Published: July 2022

This study uses survey data from 651 farmers in China to study the impacts of moral hazard on rice harvest losses and we further study the differences of the impacts across farm scales. The results show that large-scale farms have lower harvest losses and the service providers have more serious attitude when harvesting. After addressing the endogeneity of moral hazard using instrumental variable approach, moral hazard increases harvest losses. However, this impact diminishes as farm size increases. These findings demonstrate the need to reduce moral hazard by increasing farm size, introducing intermediaries, and written contracts, etc.
Analisis Penggunaan Google Form Dalam Pelaksanaan PTS di Masa Pandemi Covid-19 Siswa Kelas V SD Negeri 01 Kebondalem
Authors: Sheila Marifa Lian , Fita Asri Untari Mei , Ardiyanto Asep
Published: July 2022

The Covid-19 pandemic hit Indonesia in mid-March 2020, so the education system in Indonesia had to change. The learning process that was originally done face-to-face now has to be done online or remotely. From this, teachers must be able to use or utilize media or technology as alternative media in the learning process or assessment process. This study aims to analyze the use of Google Forms in the implementation of PTS during the Covid-19 pandemic as an alternative media for fifth grade students of SD Negeri 01 Kebondalem Pemalang Regency and find out the advantages and disadvantages of using it. The method used in this research is descriptive qualitative research method. The data in this study were obtained using data collection techniques in the form of observation, interviews, questionnaires, and documentation. Based on the research, it can be concluded that the use of Google Form can make it easier for teachers to distribute PTS questions to students and make it easier for teachers to make assessments. The shortcomings in its use are that students have difficulty accessing links caused by the availability of quotas, signal interference which can cause pages to not be opened or errors to occur. Another obstacle is that the cellphones used by students are partly owned by their parents so that teachers find it difficult to determine the time limit for work
Upaya Guru dalam Meningkatkan Keterampilan Membaca pada Pembelajaran Pandemi di Kelas Rendah
Authors: Priaga Welly , Siswanto Edi
Published: July 2022

Penelitian ini bermaksud menggali secara lebih mendalam sesuai dengan kondisi yang terjadi dan menggambarkan upaya guru dalam meningkatkan keterampilan membaca siswa kelas rendah di masa pandemi Covid-19. Penelitian ini dilakukan di SDN 19 Pangkalpinang. Waktu yang dipakai dalam penelitian dilaksanakan 4 bulan, yakni bulan September sampai Desember tahun ajaran 2021/2022. Terdapat dua subjek penelitian yakni, satu orang guru kelas II A dan juga peserta didik kelas II A SDN 19 Pangkalpinang yang memiliki berjumlah 37 peserta didik. Teknik data dalam penelitian ini adalah observasi, wawancara semi terstuktur, dan dokumentasi. Hasil penelitian yaitu guru memiliki upaya tersendiri sehingga mengalami peningkatan yang peneliti simpulkan sebagai upaya 6M, sebagai berikut: 1). Mengkategorikan, 2). Menvideokan, 3). Memotivasi, 4). Mengajar dengan Metode SAS, 5). Mengunjungi, 6). Menjalin Kerja Sama dengan Orang Tua, hal ini membuat peningkatan yang signifikan terhadap keterampilan membaca peserta didik.
Analisis Guru untuk Meningkatkan Minat Belajar Siswa di Sekolah Dasar
Authors: Amelia Mila , Yarmi Gusti , Hasanah Uswatun
Published: July 2022

The purpose of this study was to analyze the teacher's strategies in improving interest in learning in the first grade of SD Negeri Cipadu 01 Jalan Mutiara, No. 71, Cipadu Village, Larangan District, South Tangerang City. This research method is qualitative approach, with a descriptive approach. Based on the results of research on improving interest in learning in the first grade of SD Negeri Cipadu 01 by inviting students to make observations and discuss. Provide time for students to ask questions and provide opportunities for other students to answer these questions. Teachers also use a variety of learning media and evaluate theoretically and practically.
Genealogical Transmission of Zakariyya al-Ansari’s Thought on Tawhid to the Malay World Scholars with Special Reference to His Fath al-Rahman
Authors: Saari Che Zarrina , Zarkasyi Maimunah , Abd. Latif Faizuri
Published: July 2022

In Islamic history, Haramayn (Mecca and Medina) were once became a centre of education for Muslim scholars from all over the world. They came here to study all branches of Islamic knowledge from many prominent scholars. In the 17th century, the Egyptian scholar, Zakariyya al-Ansari (d. 1520) had produced a significant work, Fath al-Rahman that became well-known in the circle of studies in Haramayn. The work consists the exposition of true and pure Tawhid as a foundation to learn Shari`ah and Haqiqah (Truth). The ideas that were cast in this work were very important which later became the subject of study among the scholars and their disciples as well as their successors. In the 18th century, the Fath al-Rahman was of wide-spread in Malay Archipelago. By applying the qualitative research method based on texts and documentations analysis, this research reveals the transmission of Zakariyya’s thought that were documented in Fath al-Rahman to Malay society occurred through the Malay scholars famed and outstanding as group of al-Jawiyyin such as Nuruddin al-Raniri, Abdul Rauf al-Sinkili, Yusuf al-Makassari and others. They brought back the Fath al-Rahman and taught it in the circle of religious students in Malay world. Some of them put initiatives to further translated and commented on the work. The works are currently available in several places around Malay Archipelago including Indonesia and Malaysia and, as such, indicating the transmission of Zakariyya’s thought and signifying an intellectual network between scholars in Haramayn and the Malay world.
Syed Syeikh Ahmad al-Hadi’s Thought on Women’s Emancipation and Gender Equality: Re-Evaluation and Analysis
Authors: Hamisan @ Khair Nur Saadah
Published: July 2022

Known as the early 20th century Malay-Muslim scholar, Syed Syeikh Ahmad al-Hadi (1867-1934) has written several works concerning women’s issues; including Faridah Hanom, Hikayat Anak Dara Ghasan, Hikayat Puteri Nurul‘Ain, Kitab Alam Perempuan and many others. The present study attempts to examine his thought on the emancipation of women and gender equality, since not many Malay scholars focus on a similar issue during his time. This paper discusses on the development of his idea through magazines and novels since the 1920s, which later gave impact to the Malay society from cultural, social, political as well as religious aspects. This study also highlights several factors which might influenced his thought by discovering his educational background and analysing his different methods of arguments applied in his writings. By using qualitative approach, the study concludes that Syed Syeikh Ahmad al-Hadi has integrated both Islamic and modern perspectives in his writings, particularly concerning women’s issues such as on the emancipation of women and gender equality. Although some of his ideas seem controversial, it was among the earliest effort to propose a change to Malay traditions, where women were often given a limited role in society, for they only had major roles in domestic affairs.
Modern Schools of Thought and Their Impact on the Sectarian Texts in the Islamic and Western Thought: Hermeneutics as an Example
Authors: Qatawneh Mohamed Abdelhamid
Published: July 2022

This study primarily seeks to find out the impact of modern schools of thought, their reading of revelation (wahy) and their attempt to turn the sacred constant to the human variable that allows absolute and infinite interpretation. This study also examines the theories, doctrines and philosophical foundations that were the reason for the existence of these schools. It also investigates the applications of these modern thoughts on doctrines. This study aims at demonstrating the methodological and scientific imbalance of these schools of thought and their projections on revelation. The study makes use of a comparative analytical approach that analyses and assesses these schools and approaches. The study concludes that Hermeneutics as a modern approach take on interpreting the holy text and in particular in regard to belief issues are far from the best practices of interpretation and that they distort the source of meaning and message.
Medieval Theoretical Principles of Medicine in Ibn Sīnā’s al-Qānūn fī al-Ṭibb and al-Dhahabī’s al-Ṭibb al-Nabawī
Authors: Muhammad Yusoff Muhammad Fawwaz , Ab Razak Nur Izah
Published: July 2022

The Galenic account of medicine by Ibn Sīnā (d. 427AH/1037CE) was remarkably significant for natural philosophy and religious thought in the medieval Islamic world. Just as one might split philosophy in the Islamic world into eras before and after Avicenna, so one could periodise medical history into the time before and after Ibn Sīnā’s glorious al-Qānūn fī al-Ṭibb (Canon of Medicine). This article compares the medical theory in al-Qānūn fī al-Ṭibb and al-Dhahabī’s (d. 748/1348) al-Ṭibb al-Nabawī to determine if the medieval al-Ṭibb al-Nabawī genre was influenced by the post-Avicennian tradition. To assess this theoretical impact on the writing in the prophetic medicine genre, the article first analyses the introductory part of both writings, as well as the subsequent developments in al-Ṭibb al-Nabawī writings. This will form a comparative view of the medieval anatomical and philosophical positions. Given that traditional prophetic medicine is the focus of the al-Ṭibb al-Nabawī genre, the article turns to the question of medical theory, did al-Dhahabī really observe this topic? What role does medical ḥadīth play in determining how Muslims should approach classical theories of medicine? By comparing these two works, one can see that al-Dhahabī’s al-Ṭibb al-Nabawī developed in interaction with and extension of the al-Qānūn fī al-Ṭibb, as well as an attempt to bring forth a new form of medicine, that would integrate Ibn Sīnā’s medical theory with Prophetic ḥadīth.
Un estudio sobre el autoliderazgo, la autoeficacia emprendedora y la innovación en la generación de los Centennials en estudiantes de la FESC
Authors: Herrera-Laguna Victoria-Yamileth , Sanchez Mojica Karla Yohana , Guzmán-Soria Eugenio
Published: July 2022

En la actualidad el percibir lo que los empleados actuales y futuros consideran más importante puede ser difícil cuando esas expectativas están cambiando por la globalización, la competitividad y el mismo mercado, el sector empresarial se ha visto afectado. Por lo cual, la población objetivo fueron los universitarios pertenecientes a una generación conocida como Centennials o Z, quienes buscan nuevas tendencias, ambientes e independencia laboral, por lo que muchos de ellos emprenden.  El presente trabajo validó la influencia de tres variables: autoliderazgo, autoeficacia emprendedora y la innovación en estudiantes de la Fundación de Estudios Superiores Comfanorte en Colombia, obteniendo resultados preliminares empleando el software de análisis estadístico (SmartPLS).
3-D generalized analytic signal associated with linear canonical transform in Clifford biquaternion domain
Authors: Cai Zhenfeng , Kou Kit Ian
Published: July 2022

The analytic signal is a useful mathematical tool. It separates
qualitative and quantitative information of a signal in form of the
local phase and local amplitude. The Clifford Fourier transform (CFT)
plays a vital role in the representation of multidimensional signals. By
generalizing the CFT to the Clifford linear canonical transform (CLCT),
we present a new type of Clifford biquaternionic analytic signal. Due to
the advantages of more freedom, the envelop detection problems of 3D
images, with the help of this new analytic signal, can get a better
visual appearance. Synthesis examples are presented to demonstrate these
advantages.
Type 3 of progressive familial intrahepatic cholestasis (PFIC-3): Case report
Authors: Almoshantaf Mohammad , alasaad Suja , Alzabibi Mhd , Shibani Mosa , EZZDEAN WEAAM
Published: July 2022

Progressive familial intrahepatic cholestasis (PFIC) is an abnormality
in the formation and secretion of bile components and bile acids.We
present a case of a 6-years-old female with Type 3 of PFIC which was
confirmed via detecting pathogenic variants in the ABCB4 gene.
Mucormycosis in patients with COVID-19 in Russia: the results of a prospective multi-center study
Authors: Khostelidi S. N. , Zaytsev V. A. , Vartanyan S. A. , Nikitin N. A. , Evtukh G. N. , Gilalov M. N. , Portnov G. V. , Zubareva A. A. , Baranova I. B. , Bogomolova T. S. , Avdeenko Yu. L. , Shadrivova O. V. , Desyatik E. A. , Shagdileeva E. V. , Borzova Yu. V. , Krivolapov Yu. A. , Vasilyeva N. V. , Klimko N. N.
Published: July 2022

We present the results of a prospective multicenter study of risk factors, etiology, clinical features, and treatment outcomes for mucormycosis in patients with COVID-19 (COVID-M) in the Russian Federation.

The study included 60 adult patients with COVID-M. To analyze risk factors for COVID-M, we conducted a case-control study. The control group included 60 adult patients with COVID-19 without mucormycosis. To analyze the clinical manifestations of COVID-M, we created a control group of hematological patients with mucormycosis examined in 2011–2020.

In patients with COVID-19, the risk of developing mucormycosis was significantly increased with diabetes mellitus (OR=49) and overweight (OR=4,75), as well as with the use of high (≥100 mg per day for prednisolone) doses of glucocorticosteroids (OR= 4,762), especially ≥10 days (OR=25,4). The main localization of mucormycosis in patients with COVID-19 was the paranasal sinuses (95%) and the orbit (68%). Involvement of ≥2 organs was identified in 70% of patients. The main causative agents of mucormycosis were Rhizopus arrhizus (43%) and unidentified mucormycetes (36%).

90-days overall survival of patients with mucormycosis and COVID-19 – 71%. The stay in the ICU (p=0,01), the use of mechanical ventilation (p=0,0481), the presence of CVC (p=0,049), CNS damage (p=0,016) and ≥ 2 organs (p=0,048) significantly worsened the prognosis of the disease. The best prognosis was in patients who received antifungal therapy (p=0,03875) and surgical treatment (p=0,046).
Efficacy and safety of vector vaccines for the prevention of new coronavirus infection
Authors: Kharit S. M. , Fridman I. V.
Published: July 2022

The review article discusses vaccines against SARS-CoV 2 based on adenovirus vectors currently used in the world. The concept of creating vector vaccines is described. The data of clinical studies on the efficacy and safety of registered adenovirus-vector vaccines for the prevention of new coronavirus infection are presented. The frequency of serious adverse events after their use is described in detail. In addition, the clinical efficacy of vector vaccines for changing genotypes of the Covid 19 virus has been determined.

The review analyzes literature data on the safety and efficacy of vector vaccines against coronavirus infection.

The vector vaccines currently used against the new coronavirus infection are quite safe and effective even in relation to the new genotypes of the SARS-CoV 2 virus.
The state of the cardiovascular system in typhoid fever (Experience of a leading infectious disease specialist of a limited contingent of Soviet troops in Afghanistan)
Authors: Ljashenko Yu. I.
Published: July 2022

In order to clarify the frequency and duration of changes in the functional state of the cardiovascular system in typhoid patients, as well as the definition of the structure and features of injuries in modern conditions, the medical records of 286 patients were analysed retrospectively, including 36 persons with a fatal outcome among members of a limited contingent of Soviet troops in Afghanistan (1983–1985). The results of the tests in the deceased were compared to the autopsy of the tissues of their bodies.

The nature of the changes in the indicators of the functional state of the cardiovascular system during various periods of light, medium, heavy and extremely severe forms of typhoid fever and their diagnostic informativeness, structure, as well as the frequency of registration are explained, features of clinical and morphological manifestations of infectious toxicity shock, thrombohemorrhagic syndrome, myocardial dystrophy, infectious toxicity myocarditis, as well as the significance of pre-mortem status in this disease. It has been established that patients with an extremely severe form of relapse of typhoid in connective tissue develop in the intercardiomyocytic intervals.
Chronicle
Authors: Editorial Article
Published: July 2022

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Infectious endocarditis in HIV-infected intensive care unit patients
Authors: Kharlamova T. V. , Voznesenskiy S. L. , Ermak T. N. , Kozhevnikova G. M. , Klimkova P. V.
Published: July 2022

Infective endocarditis (IE) is one of the most common cardiac complications in HIV patients who are intravenous drug addicts. The presence of IE and secondary diseases in immunocompromised individuals usually requires specific diagnostic and therapeutic approach.

Aim: Optimizing the diagnosis of IE in patients with advanced HIV/AIDS.

Materials and methods We reviewed 429 case records of HIV/AIDS ICU patients using the modified duke criteria for diagnosis of infective endocarditis. Statistical significance (p <0.05) of data was assessed using the χ2 test.

Results. 25 patients were diagnosed with IE. The male gender dominated – 68%. Mean age was 38. 60% had stage 4B HIV infection. 68% were ART naive. The medium viral load was 294560 copies / ml, while the medium CD4 count was 218 cells / μl. Fever of >38°C was a key symptom found in all patients. Blood cultures were positive in 60% cases. 80% had a high C reactive protein (CRP), and 44% had CRP levels above 100 mg/l. Procalcitonin (PCT) levels were increased in 52%. Echocardiogram revealed IE in 92%. Pneumonia was diagnosed in 92%. Fatal outcome occurred in 76%. Anemia was a predictor of severe outcome (p<0.002), while patients with leukocytosis had good prognosis (p<0.05).

Conclusion. Infective endocarditis is a common complication among HIV IDUs. The most common diagnostic criteria are fever >38°C, pneumonia, anemia, leukocytosis, thrombocytopenia and echocardiographic findings. The levels of the hemoglobin and WBCs could evaluate prognosis of the disease outcome.
Cytomegalovirus infection in immunocompetent pregnant women: clinical manifestations and management tactics
Authors: Rogozina N. V. , Vasil’ev V. V. , Bezverhaja N. S. , Ivanova R. A. , Ushakova G. M. , Romanova E. S.
Published: July 2022

Objective: to analyze clinical manifestations, diagnostic and therapeutic approaches to management of pregnant women with cytomegalovirus infection for optimization of clinical and laboratory diagnostics and reduction of risks of congenital cytomegalovirus infection in the postnatal period.

Materials and methods: in the article describe results a retrospective study the pregnancy course of 92 women who had 94 children with a confirmed congenital manifest form of cytomegalovirus infection. The inclusion criteria in main group were women aged 18-40 years and presence the results of examination for TORCH-syndrome in the first trimester of pregnancy, negative results for HIV. Markers of cytomegalovirus infection were determined by PCR (blood, vaginal secretions) and serologically (IgM, IgG to CMV-infection).

Findings: the study showed that acute cytomegalovirus infection was documented during pregnancy in 18.4% of cases, and recrudescence of CMV-infection only in 33.6% of cases. Acute cytomegalovirus infection was asymptomatic in 35.3% of patients, the rest had nonspecific symptoms in the form of fatigue and headache, cholestasis was registered in 35.2% of cases, whereas with recrudescence of cytomegalovirus infection, catarrhal symptoms in the form of rhinitis and pharyngitis prevailed 42,8% cases, p<0,05. 15 people received therapy during pregnancy: 2 of them – antiviral (valgancyclovir), 11 – immunocorrective (interferon2alfa) and 2 – pathogenetic therapy (blood transfusion to the fetus for anemia). Based on the literature data and obtained by analyzing management tactics of the observed pregnant women, an algorithm for the management of pregnant women with cytomegalovirus infection was created.

Conclusion: the study made it possible to substantiate algorithm of diagnosis and tactics management of cytomegalovirus infection in immunocompetent pregnant women and gave recommendations for obstetricians and gynecologists about alertness regarding cytomegalovirus infection.
Surgical treatment of parathyroid cysts: Case series and review of literature
Authors: Odalovic Bozidar , Buzejic Matija , Zoric Goran , Rovcanin Branislav , Zivaljevic Vladan , Cvetkovic Sasa , Husovic Damir , Paunovic Ivan
Published: July 2022

Introduction. Parathyroid cysts (PCs) are divided into two categories: functional and nonfunctional. If large enough, both types of PCs can present as a mediastinal or cervical mass in 1?5% of patients. Case report. A retrospective analysis of the data on patients operated on for primary hyperparathyroidism or cervical/mediastinal mass from 2016 to 2021 was conducted. An analysis of the demographic data of the patients, data on preoperative fine needle aspiration biopsy, level of parathyroid hormone in serum pre- and postoperatively, level of serum calcium, as well as on clinical presentation of the disease, was carried out. In this five-year period, a total of 555 patients were operated on, in whom the parathyroid gland was described as a definitive pathohistological finding. Of the total number, PCs were found in seven cases. In five out of the seven cases, PC was nonfunctional. Four female and three male patients were operated on due to PC. The mean age of operated patients was 49.8 years. In one patient, the nonfunctional cyst was represented as a cervical and upper mediastinal mass with a maximal diameter of 10 cm. Conclusion. Although PCs represent about 0.5% of all changes in the parathyroid glands, they can be suspected preoperatively, especially if a water-like liquid is obtained by a fine needle aspiration biopsy. In order to remove the PC completely without making a lesion on the capsule, with the aim of avoiding parathyreomatosis, but to preserve the recurrent laryngeal nerves, the operation should be performed by an experienced endocrine surgeon.
Remnant Cholesterol and Its Visit-to-visit Variability Predict Cardiovascular Outcomes in Patients with Type 2 Diabetes Mellitus: Findings from the ACCORD Cohort
Authors: Fu Liyao , Tai Shi , Sun Jiaxing , Zhang Ningjie , Zhou Ying , Xing Zhenhua , Wang Yongjun , Zhou Shenghua
Published: July 2022

  

Objective: Remnant cholesterol (remnant-C) predicts atherosclerotic cardiovascular disease, regardless of LDL cholesterol (LDL-C) levels. This study assessed the associations between remnant-C and cardiovascular outcomes in type 2 diabetes mellitus. 

Research design and methods: This post-hoc analysis of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial used patient (type 2 diabetes >3 months) remnant-C and major adverse cardiovascular event (MACE) data from the study database. The associations between remnant-C and MACEs were evaluated using Cox proportional hazards regression analyses. We examined the relative MACE risk in remnant-C versus LDL-C discordant/concordant groups using clinically relevant LDL-C targets by discordance analyses.

Results: The baseline analysis included 10,196 participants, with further visit-to-visit variability analysis including 9650 participants. During follow-up (median, 8.8 years), 1815 (17.8%) patients developed MACEs. After adjusting for traditional cardiovascular risk factors, each 1-SD increase in remnant-C was associated with a 7% higher MACE risk (HR=1.07, 95% CI: 1.02-1.12; P=0.004). In the fully adjusted model, the visit-to-visit remnant-C variability calculated using logSD (HR=1.41, 95% CI: 1.18-1.69, P<0.001) and logARV (HR=1.45, 95% CI: 1.22-1.73, P<0.001) was associated with MACEs. Residual lipid risk (remnant-C ³31 mg/dL) recognized individuals at a higher MACE risk, regardless of LDL-C concentrations. Within each LDL-C subgroup (>100 or ≤100 mg/dL), high baseline remnant-C was associated with a higher MACE risk (HR=1.37, 95% CI: 1.09-1.73; P=0.007; HR=1.22, 95% CI: 1.04-1.41; P=0.015, respectively).

Conclusions: Remnant-C levels were associated with MACEs in type 2 diabetic patients independent of LDL-C, and visit-to-visit remnant-C variability helped identify those with higher cardiovascular risk.
Importancia de los recursos audiovisuales en la educación: por un camino hacia la inclusión educativa
Authors: ELEZME MARTIN MARLY XIOMARA
Published: July 2022

Los recursos educativos son elementos fundamentales en el proceso de enseñanza aprendizaje, ayudan a fortalecer los aprendizajes de los estudiantes y permiten que el docente planifique sus actividades educativas diseñando o seleccionando materiales que a través de diferentes estrategias le permitan alcanzar una intensión pedagógica determinada. Un aliado clave para este proceso pedagógico es el uso de las tecnologías de información y comunicación, con ella es posible transformar los contenidos en recursos educativos adaptados a las necesidades de las generaciones actuales que han encontrado en los medios digitales educación incluyente y participativa.
Fórmulas para una administración diferente: la tecnología con base en la integridad desde las formas de articulación hasta los puntos de realización
Authors: MOVIL GUERRA MARIA TERESA , VACCA ASCANIO RONALD ALEXANDER
Published: July 2022

Las instituciones, están experimentado un cambio de cierta importancia en el conjunto del sistema integrativo de la sociedad actual, con ello traen el desplazamiento de los procesos de formación desde los entornos convencionales hasta otros ámbitos; así como la atención a las demandas generalizadas de que los beneficiados reciban las competencias necesarias para el aprendizaje continuo; comercialización del conocimiento, que genera simultáneamente oportunidades para nuevos mercados y competencias en el sector, entre otros. En este sentido, el ámbito de las formas de articulación y de realización varía de forma vertiginosa, según Salinas (2018), pues las instituciones, tienen que reajustar sus sistemas de distribución y comunicación. Por ello, las Instituciones pasan de ser el centro de la estrella de comunicación integral a constituir simples nodos de un entramado de redes entre las que se mueven en unas coordenadas más flexibles, y que se ha denominado ciberespacio. Por otra parte, los cambios en estas coordenadas espacio-temporales traen consigo la aparición de nuevas organizaciones de enseñanza, que se constituyen como consorcios o redes de instituciones y cuyos sistemas de enseñanza se caracterizan por el modularidad como por la interconexión. Todo ello exige a las instituciones una flexibilización de sus procedimientos y de su estructura administrativa.
Nivel de innovación del talento humano en pymes apoyadas en el SENA CGA
Authors: Arévalo Hernández Franklin Giovanni
Published: July 2022

La innovación y la participación activa del talento humano en las pymes es base fundamental para que las organizaciones potencialicen la productividad y permitan el desempeño de cada integrante de la misma. La estructura de esta investigación trabajó bajo dos metodologías; las cuales fueron bibliográfica y la investigación IAP (Investigación de Acción Participativa). El proyecto se enfoco en identificar la capacidad innovadora del talento humano de pymes apoyadas desde las estrategias de formación del SENA CGA, realizando un desarrollo conceptual, sobre el nivel de innovación de pymes  en Colombia y la capacidad innovadora de su talento humano, estos conceptos se utilizaron como apoyo para el desarrollo del proyecto basado en los temas expuestos anteriormente, luego de esto se aplico un diagnóstico a dichas organizaciones, para analizar sus puntos de vista y el manejo en cuanto a la innovación, la información recabada permitio establecer que se promueven pocas estrategias empresariales y la baja participación que tiene el talento humano, en este sentido existe la necesidad de diseñar e implementar estrategias y herramientas para potencializar la participación activa de sus colaboradores con relación a este tema.
CONCEPTUALIZATION OF FEAR IN RUSSIAN AND ENGLISH PAROEMIAS: COMPARATIVE ASPECT
Authors: ERMAKOVA LIUBOV A. , LAVROVA SVETLANA YU.
Published: July 2022

The article deals with a comparative analysis of Russian and English paroemias with the conceptual meaning of ‘fear’. Particular attention is paid to the system of language means expressing the evaluative semantics of the paremiological constructions under study. The comparison of paroemias in two languages proves that the target concepts have predominantly negative connotations; their verbalization is carried out in paroemias on the basis of cause-effect relations of an evaluative nature. The novelty of this paper lies in a comparative analysis of the fear phenomenon as a conceptualized essence in Russian and English paroemias. The concept of fear is studied in specific coordinates of evaluative causation, the behavioral norm of the paroemia subjects and the characteristics of the chronotope in which the reference is realised.
A new species of the genus Leptobium Casey (Coleoptera: Staphylinidae: Paederinae) from central northern Anatolia, and a distributional checklist to Turkish species
Authors: ANLAŞ Sinan
Published: July 2022

In the study, a new species of the genus Leptobium Casey from central northern Anatolia in Turkey is described, illustrated, and distinguished from congeners: Leptobium orgeli sp. n. (Çorum province). Distributions of the endemic Leptobium species in central northern Anatolia are mapped. Additional records of five species of Leptobium from Turkey are presented. A total of 21 species is now known from Turkey.