bluuebunny/crossref_metadata_2025 huggingface dataset:
Cycloaddition of (E)-N-[2-([2.2]paracyclophan-4-yl)ethylidene] methylamine-N-oxide with 2,3-diphenylcyclopropenones and dibenzoyl acetylene; synthesis of new paracyclophanylpyrroles
Authors: Aly Ashraf A.
Published: December 2009

When N-[2-([2.2]paracyclophan-4-yl)ethylidene]methylamine- N-oxide (1) is treated with cyclopropenones 6a–c, the [2.2]paracyclophane-based pyrrole(-2-one, -thione and -ylidene malnonitrile) 7a–c are formed in good yields via formal [3π + 3π]cycloaddition. The reaction of 1 with dibenzoyl acetylene (12) afforded, via a Michael-type reaction, the stereoisomeric pyrrole 13. The reaction mechanism described the products formation is discussed.
One-pot Synthesis of Stable Phosphite Ylides by three component reaction between Acetylenic Esters, Aldehyde Semicarbazones and Tributyl or Triethyl Phosphite
Authors: Anary-Abbasinejad Mohammad , Hassanabadi Alireza , Anaraki-Ardakani Hossein
Published: December 2009

Three-component reaction between acetylenic esters, aldehyde semicarbazones and tributyl- or triethyl phosphite leads to stable crystalline phosphite ylides at one step in nearly quantitative yields.
CuI/1,10-phenanthroline: An efficient Catalyst System for the Cyanation of Aryl Halides
Authors: Zhu Yi-Zhong , Cai Chun
Published: December 2009

Aryl nitriles have been prepared in good yields from the corresponding aryl halides with potassium hexacyanoferrate(II) using CuI/1,10-phenanthroline as the catalyst system. Furthermore, the reaction is compatible with a wide range of functional groups including nitro and carbonyl substituents.
Synthesis of Novel Spiro Compounds using Anthrone and Pyrazole-5-thione Moieties: A Michael Addition approach
Authors: Chande Madhukar S. , Khanwelkar Rahul R. , Barve Pravin A.
Published: December 2009

Novel routes for the synthesis of spiro derivatives anthrone have been designed using a Michael addition reaction followed by a Dieckmann condensation and Thorpe–Ziegler cyclisation. Bis-Michael addition of pyrazole-5-thione with 1,5-diarylpenta-1,4-dien-3-one gave directly a spiro derivative of pyrazole-5-thione. An enol lactone was synthesised by using mono Michael addition on dimedone, followed by hydrolysis and condensation.
Stereoselective One-Pot Synthesis of Functionalised Phosphonates by three-component reaction between Trialkyl(aryl) Phosphites, Dimethyl Acetylenedicarboxylate and indan-1,3-dione or N,N′-dimethylbarbituric acid
Authors: Anary-Abbasinejad Mohammad , Hassanabadi Alireza
Published: December 2009

Protonation of the reactive intermediate produced in the reaction between trialkyl(aryl) phosphites and dimethyl acetylenedicarboxylate by CH- acids such as indane-1,3-dione and N,N′-dimethylbarbituric acid leads to functionalised phosphonates in good yields.
Synthesis and Tautomeric Structure of 2-arylazo-4H-imidazo[2,1-b][1,3,4]thiadiazines
Authors: Shawali Ahmad S. , Mosselhi Mosselhi A.N. , Farghaly Thoraya A.
Published: December 2009

Two series of the title compounds were prepared via reaction of N-aryl 2-oxohydrazonoyl halides with 1-amino-4-phenylimidazoline-2-thione. Their tautomeric structure was elucidated by spectral analysis, and the correlation of their acid dissociation constants with the Hammett equation, to be as the hydrazone form.
Reduction of Pyrimidine Derivatives by LiAlH4
Authors: Yu-Xiu Liu , Ming-Bo Cui , Qi-Qi Zhao , Qing-Min Wang , Ying Liu , Run-Qiu Huang
Published: December 2009

The reduction of ethyl 2-methylthio-(or 2-ethoxy)pyrimidine-5-carboxylate by LiAlH4 afforded ethyl 2-methylthio-(or 2-ethoxy)-1,6-dihydropyrimidine-5-carboxylate as the main product. Similarly, the reduction of 2-methylthio-(or 2-methoxy)pyrimidine-5-carboxamide by LiAlH4 gave 2-methylthio-(or 2-methoxy)-1,6-dihydropyrimidine-5-carbonitrile as main product.
Improved Synthesis of Methyl 3-oxo-2,6,6-trimethylcyclohex-1-ene-1-carboxylate, an A-ring intermediate for (±)strigol
Authors: Qianchao  , Shiqing Pi , Xinzhi Chen
Published: December 2009

Methyl 3-oxo-2,6,6-trimethylcyclohex-1-ene-1-carboxylate was synthesised over eight steps from the starting material of citral instead of α-ionone. KMnO4, HC(OEt)3 and O2/TEMPO/CuCl were substituted for NaIO4, CH3I and pyridinium chlorochromate, respectively. Every step was simplified and gave a 48% overall yield. The procedure is suitable for large scale production.
Selenium containing Heterocycles: Part 1. Synthesis of Some New Substituted Pyrido[3′,2′:4,5]selenolo[3,2-d]pyrimidines and Related Fused Tetracyclic Systems
Authors: Abdel-Hafez Shams H. , Ahmed Ragaa A. , Abdel-Azim Mohamed A. , Hassan Khairy M.
Published: December 2009

New series of selenolo[2,3- b]pyridine, pyrido[3′,2′:4,5]selenolo[3,2- d]pyrimidine, 7,8-dihydro-2,4-dimethylpyrrolo [1,2- a]pyrido[3′,2′:4,5]selenolo[3,2- d]pyrimidin-10(6 H)-one and 7,9-dimethylpyrido[3′,2′:4,5]selenolo[3,2- d][1,2,4] triazolo[4,3- c]pyrimidine derivatives were synthesised from 3-cyano-4,6-dimethylpyridine-2(1 H)-selenone (1). Spectroscopic (IR, 1H, MS) of the newly synthesised compounds are reported.
A One-Pot Synthesis of Functionalised 3-pyrolin-2-ones by a four-component reaction between Triphenylphosphine, Primary Amines, Dimethyl Acetylenedicarboxylate and Ethyl Chlorooxoacetate
Authors: Anary-Abbasinejad Mohammad , Anaraki-Ardakani Hossein , Dehghan Alimohammad , Hassanabadi Alireza , Seyedmir Mohammad Reza
Published: December 2009

Reaction between triphenylphosphine, dimethy acetylenedicarboxylate and amines produces phosphorus ylids which undergo a smooth reaction with ethyl chlorooxoacetate and triethylamine to produce dimethyl N-aryl-(or alkyl)-4-ethoxy-5-oxo-2,5-dihydro-1 H-pyrole-2,3-dicarboxylates in high yields.
Reaction of N-imidoylthioureas with Dimethyl Acetylenedicarboxylate: Synthesis of new 1,3,5-thiadiazepines
Authors: Aly Ashraf A. , El-Shaieb Kamal M.
Published: December 2009

The reaction of N-imidoylthioureas 2a–e with dimethyl acetylenedicarboxylate (DMAD, 1) led unexpectedly to the 1,3,5-thiadiazepines 6a–e. The mechanism of the reaction is discussed.
Regioselective Copper-Catalysed Amination of Halobenzoic Acids using Aromatic Amines
Authors: Maradolla Mohan Babu , Mandha Amaravathi , Garimella Chandra Mouli
Published: December 2009

Copper dipyridine dichloride (CuPy2Cl2) has been found to be an efficient catalyst for the synthesis of N-arylanthranilic acids from ortho halobenzoic acids and aromatic amines under microwave irradiation. Some of the advantages of this method are high chemoselectivity, ease of operation, less reaction times and high yields. (61–98%).
An Efficient Synthesis of Bibenzylic Oxygen Heterocycles
Authors: Kumbhar Virendra B. , Joseph Augustine R. , Natu Arun D. , Kusurkar Radhika S. , Paradkar Madhusudan V.
Published: December 2009

The first total syntheses of naturally occurring 6-methoxy-4-(2-phenylethyl)benzofuran (1) and 2,2-dimethyl-7-methoxy-5-(2-phenylethyl)chroman (2) and the non-natural 7-methoxy-5-(2-phenylethyl)chromen-2-one (3) are described from 3,5-dimethoxyphenylacetic acid in good yields.
Rapid Catalyst-free Carbon–carbon Bonds Coupling Reaction under Ambient Conditions and Ultrasonic Irradiation
Authors: Shi Qinghong
Published: December 2009

The catalyst-free coupling reaction of sodium tetraphenylborate with hypervalent iodine compounds was achieved under ultrasonic irradiation in water without a base, providing a convenient and rapid method for the formation of carbon–carbon bonds in good yield.
Stereospecific Synthesis of 1,4-di-O-methyl-myo-inositol (liriodendritol)
Authors: Kelebekli Latif
Published: December 2009

1,4-di- O-methyl- myo-inositol, a natural product, was synthesised starting from p-benzoquinone. The treatment of 5,6-dibromocyclohex-2-ene-1,4-diol with Na/ROH-system afforded a C2-symmetric conduritol-B derivative key intermediate followed by acetylation. The OsO4 oxidation and followed by acetylation gave the tetraacetates. The hydrolysis of the acetate groups furnished the desired the myo-inositol derivatives in high yield.
Indenoxadiazine, Indenopyrazole and Spiro Triazole Derivatives from (substituted ylidene)-N-phenylhydrazine Carbothioamides
Authors: Hassan Alaa A. , Shehata Hamdy S.
Published: December 2009

In a multistep reaction, indeno[2,1- e][1,3,4]oxadiazine-9-one, oxoindeno[1,2- c]- pyrazolecarbothioamide, (thioxo-1,2,4-triazaspiro[4.5]decadienylidene)malononitrile and spiro-(fluorine-9,3′-[1,2,4]triazoline)-5′-thione derivatives have been formed from a series of (substituted ylidene)- N-phenylhydrazinecarbothioamides 1a–e with (1,3-dioxo-2,3-dihydro-1 H-inden-2-ylidene)propanedinitrile, 7,7′,8,8′-tetracyanoquinodimethane and (2,4,7-trinitro-9 H-fluoren-9-ylidene)propanedinitrile in aerated pyridine. Rationales of these conversions involving the nucleophilic reactions, condensation, dehydrogenation and oxidation are presented.
An Efficient Synthesis of Resveratrol and a Hydroxyl Derivative via the Perkin Reaction: cis to trans Isomerisation in a Demethylation Process
Authors: Li Guoxing , Zou Yong , Zhang Xuejing
Published: December 2009

Two trans polyphenolic stilbenes, Resveratrol and 3,4,4′,5- trans-tetrahydroxystilbene, were prepared in three steps from 4-methoxy phenylacetic acid and methoxylated benzaldehydes via a Perkin reaction. An interesting cis to trans isomerisation occured in the demethylation process in the presence of AlI3 and acetonitrile to give resveratrol and 3,4,4′,5- trans-tetrahydroxystilbene with overall yields of 51% and 48% respectively.
Reactions of methyl 2-(1-oxo-2,3,4,9-tetrahydro-1H-carbazol-2-yl) oxoacetates. Synthesis of methyl isoxazolo[5,4-a]carbazole-3-carboxylates
Authors: Martin Arputharaj Ebenezer , Prasad Karnam Jayarampillai Rajendra
Published: December 2009

The reaction of methyl 2-(1-oxo-2,3,4,9-tetrahydro-1 H-carbazol-2-yl)oxoacetates (1a-e) with hydroxylamine hydrochloride in alcoholic KOH afforded 1-hydroxyimino-2,3,4,9-tetrahydro-1 H-carbazoles (2a-e), and in acetic acid methyl isoxazolo[5,4- a]carbazole-3-carboxylates (3a-e). Ketoesters 1a-e with urea and thiourea under acidic conditions yielded a mixture of the respective 1-hydroxycarbazoles (6a-e) and 2,3,4,9-tetrahydro-1 H-carbazol-1-ones (7a-e), but under basic conditions the respective 1-carbimido- and 1-thiocarbimido-2,3,4,9-tetrahydro-1 H-carbazoles (8a-e and 9a-e) were formed. Plausible mechanisms are proposed.
Ring contraction of N-acetyl-2-aryl-1,2,3,4-tetrahydro-4-quinolones with [hydroxy(tosyloxy)iodo]benzene to trans methyl N-acetyl-2-aryl-2,3-dihydroindol-3-carboxylates
Authors: Kumar Ashok , Kumar Sunil , Gupta Rakesh K. , Kumar Devinder
Published: December 2009

The ring contraction of N-acetyl-2-aryl-1,2,3,4-tetrahydro-4-quinolones with [hydroxy(tosyloxy)iodo]benzene to trans methyl N-acetyl-2-aryl-2,3-dihydroindol-3-carboxylates in trimethylorthoformate in good yield is described.
Friedel–Crafts allylation of 2-(benzyloxy)-3,4,5-trimethoxytoluene Catalysed by a Metal Trifluoromethanesulfonic Salt: Synthesis of Coenzyme Q10
Authors: Zheng Yun-Feng , Lin Jing-Du , Li Cheng-Ping , Li Jing-Hua
Published: December 2009

In the presence of a catalytic amount of scandium triflate, 2-benzyloxy-3,4,5-trimethoxytoluene reacted with allylic derivatives 4, giving the key intermediate 3 (R = benzyl) which was used for preparing coenzyme Q10, in moderate to high yields.
MWI-promoted preparation of 4H-thiopyran derivatives through one-pot multi-component reactions
Authors: Fan Xuesen , Wang Xia , Zhang Xinying , Li Xiaoyan , Qu Guirong
Published: December 2009

One-pot reaction of aromatic aldehydes, cyanothioacetamide and malononitrile under microwave irradiation proved to be an efficient way for the synthesis of 2,6-diamino-4-aryl-4 H-thiopyran-3,5-dicarbonitriles without any added catalyst.
Synthesis of N-urethane Protected β-Amino Alcohols Employing N-(protected-α-aminoacyl)benzotriazoles
Authors: Sureshbabu Vommina V. , Sudarshan N.S. , Muralidhar L. , Narendra N.
Published: December 2009

A simple and racemisation-free synthesis of N-urethane protected α-amino/peptidyl alcohols by the reduction of the corresponding easily accessible N-acylbenzotriazoles is described. The method is practical, straightforward, fast and efficient for the synthesis of amino/peptidyl alcohols. All the alcohols made were isolated in high yields and purity.
Phosphotungstic Acid Catalysed Synthesis of β-Enamino Compounds under Solvent-Free Conditions
Authors: Li Geng-Chen
Published: December 2009

A convenient eco-friendly procedure has been developed for the synthesis of β-enaminones and β-enamino esters by reacting 1,3-dicarbonyl compounds with amines in the presence of catalytic amounts of phosphotungstic acid (H3PW12O40, 1 mol%). The reaction proceeds smoothly at room temperature under solvent-free conditions and gives the corresponding β-enamino compounds in high to excellent yields.
A Novel and Efficient Synthesis of Terminal Arylacetylenes via Sonogashira Coupling Reactions Catalysed by MCM-41-supported Bidentate Phosphine Palladium(0) Complex
Authors: Wang Yue , Huang Bin , Sheng Shouri , Cai Mingzhong
Published: December 2009

A variety of terminal arylacetylenes have been conveniently synthesised in good to high yields via Sonogashira coupling of aryl iodides with (trimethylsilyl)acetylene catalysed by a MCM-41-supported bidentate phosphine palladium(0) complex, followed by desilylation. The polymeric palladium catalyst can be reused many times without any decrease in activity.
Structural studies on bioactive compounds. 1 Heck reactions on 4-methylenepyrazolo[5,1-c][1,2,4]triazines
Authors: Iwashita Eiichiro , Williams Huw E. L. , Hutchinson Ian , Stevens Malcolm F. G.
Published: December 2009

1-(3-Methyl-4-methylenepyrazolo[5,1-c][1,2,4]triazin-6(4H-yl)ethanone 9a and its 7-methyl- 9b and 7-phenyl-derivative 9c undergo Heck coupling to afford (Z)-1-{4-benzylidene-3-methylpyrazolo[5,1-c][1,2,4]triazin-6(4H)-yl}ethanones 10a–c and substituted benzylidene analogues 10d–m as the major geometrical isomers in low yields. The most potent agent in a human tumour screen in vitro was 10b (mean GI50 value 4.9 μM in a panel of 60 human cancer cell lines), with evidence of selective action against colon KM12 (GI50 0.02 μM) and breast MCF-7 tumour cell lines (GI501.35 μM).
Reaction of 3-(substituted phenyl)-6-methyl-1,6-dihydro-1,2,4,5-tetrazine with aryl isocyanates, chloroformates and acyl chlorides
Authors: Xu Feng , Hu Wei-Xiao
Published: December 2009

23 1,6-Dihydro-1,2,4,5-tetrazine derivatives 2a-n, 3a-f, 4a-c have been synthesised by reaction of 3-(substituted phenyl)-6-methyl-1,6-dihydro-1,2,4,5-tetrazines (1a-c) with aryl isocyanates chloroformates and acyl chlorides, respectively. The yields were in the range 42-97%. It was found that a base promotes the reactions, and electron-withdrawing substituents in the benzene ring at C3 were beneficial to the yield. On substitution of the N(1) atom the conformation of the products at C(6) was inverted.
Vinyl Acetate and Sodium Carbonate as a Fast and Efficient Catalyst for per-O-acetylation of Monosaccharides
Authors: Chen Li , Zhang Jianbo , Shi Chunjuan , Wang Xiaohu , Zhang Bo , Tang Jie
Published: December 2009

Vinyl acetate and sodium carbonate catalysed acetylation of several monosaccharides is an efficient synthesis of per- O-acetylation of carbohydrates and achieve the products in excellent yields and short reaction times. d-Glucose as the substrate in large scale also proceeds in high yield.
Aliquat 336 Catalysed Three-Component Condensation in an Aqueous Media: A Synthesis of 1H- and 4H-benzochromenes
Authors: Patra Amarendra , Mahapatra Tanusri
Published: December 2009

The synthesis, under microwave irradiation, of a series of polyfunctionalised 1 H- and 4H- chromenes in water in the presence of tricaprylmethylammonium bromide (Aliquat 336) as the catalyst is reported. This method has the advantages of high yields, neutral and inexpensive medium, simple work-up procedure and environmental friendliness.
Regio-and Stereoselective Ring Opening of Epoxides with Sodium Phenylselenide under Phase Transfer Conditions
Authors: dos Santos Reginaldo Bezerra , Junior Valdemar Lacerda , Zanotto Paulo Roberto , Brocksom Timothy John , Brocksom Ursula
Published: December 2009

The ring opening reaction of a wide range of mono-, di- and trisubstituted epoxides with the phenylselenide anion under PTC conditions provides a simple, mild and efficient method for preparation of β-hydroxy phenylselenides with high regio- and stereoselectivity in yields from 67 to 98%. The reactions are carried out in aqueous NaOH/ THF using aminoiminomethanesulfinic acid (thiourea dioxide, TDO) to generate sodium phenylselenide from diphenyldiselenide.
The Reactions of the Betti Base with 1,3-Dicarbonyl Compounds
Authors: Wen Jian-Ming , Lin Cui-Pan , Li Jing-Hua
Published: December 2009

Reaction of the Betti base 1-(α-aminobenzyl)-2-naphthol with 1,3-dicarbonyl compounds at room temperature in CH3OH in the presence of p-toluenesulfonic acid leads to the corresponding enamino carbonyl products 3, in high yield and with high chemical purity. Among them, 3b was proven to be an enamine with cis-configuration by single crystal X-ray diffraction analysis.
Synthesis of 3-Methyl-6-Amino-5-Cyano-4-Aryl-1-Phenyl-1,4-Dihydropyrano [2,3-c]Pyrazole Catalysed by KF-Montmorillonite
Authors: Wu Nan , Li Xinnian , Wang Yumei , Shi Daqing
Published: December 2009

The reaction of substituted arylidenemalononitriles and 3-methyl-1-phenyl-2-pyrazolin- 5-one in DMF in the presence of KF-montmorillonite provides a rapid synthesis of 3-methyl-6-amino-5-cyano-4-aryl-1-phenyl-1,4-dihydro-pyrano[2,3-c]pyrazole derivatives.
Synthesis of Some New 2-Arylthieno[2,3-d]Pyrimidin-4(3H)-One Derivatives
Authors: Davoodnia Abolghasem , Eshghi Hossein , Salavaty Akram , Tavakoli-Hoseini Niloofar
Published: December 2009

Some new derivatives of 2-arylthieno[2,3-d]pyrimidin-4(3H)-ones have been prepared through a condensation reaction of 2-amino-4,5-dimethylthiophene-3-carboxamide with aroyl halides in boiling pyridine followed by cyclisation with 10% NaOH.
Iodine/aqueous NH4OAc: An Improved Reaction System for Direct Oxidative Conversion of Aldehydes and Alcohols Into Nitriles
Authors: Ren Yi-Ming , Zhu Yi-Zhong , Cai Chun
Published: December 2009

A convenient method for direct oxidative conversion of aldehydes and alcohols into nitriles has been developed by using the inexpensive and environmentally friendly reagent I2/aqueous NH4OAc. The aqueous NH4OAc as a nontoxic cyanide source is more eco-friendly than aqueous ammonia, because gaseous ammonia evaporates easily from aqueous ammonia but not from aqueous NH4OAc.
Piperazine-Derived Palladium Complexes Immobilised on a Merrifield Resin as a Catalyst for the Heck Reaction
Authors: Wu Xiang-Mei , Pei Wen
Published: December 2009

A palladium catalyst supported on a Merrifield resin was prepared by a simple procedure and exhibited high activity and stability for the phosphine-free Heck reaction of activated and non-activated aryl or heteroaryl substrates with olefins to afford substituted cinnamic acids, stilbenes and their hetero-aromatic relatives.
Regio- and stereospecific synthesis of a new benzoconduritol-C derivative
Authors: Kelebekli Latif
Published: December 2009

A stereospecific synthesis of 3-(2-bromophenoxy)-1,2,3,4-tetrahydronaphthalen-1,2,4-triol (benzoconduritol-C derivative) has been achieved by a fully regio- and stereospecific rhodium catalysed reaction of oxabenzonorbornadiene in the presence of 2-bromophenol.
Novel 1H-2-Benzopyran-1-One and 2,3-Benzodiazepin-1-One Derivatives
Authors: Mahmoud Mahmoud R. , El-Shahawi Manal M. , Farahat Samira E.
Published: December 2009

A number of novel 1H-2-benzopyran-1-one derivatives have been synthesised using the readily obtainable starting material obtained from the Stobbe-type condensation of diethyl homophthalate with p-anisaldehyde. Bromination, followed by hydrazinolysis, produced the tetrahydro-2,3-benzodiazepin-1-one derivative 5.
Sixty Years of the Grunwald–Winstein Equation: Development and Recent Applications
Authors: Kevill Dennis N. , D'Souza Malcolm J.
Published: December 2009

The development of scales of values for solvent nucleophilicity and for the aromatic-ring parameter are described. These are applied to solvolytic addition to carbocations and, together with improved solvent ionising power scales, to solvolyses proceeding with a 1,2-aryl shift and to solvolytic displacements at acyl carbon and at a heteroatom, such as phosphorus or sulfur.
Reaction between isocyanides and salicylic acid or 3-hydroxy-2-naphthoic acid to produce benzo or naphtho-fused 2-(alkylamino)-1,3-dioxin-4-one derivatives
Authors: Anary-Abbasinejad Mohammad , Hassanabadi Alireza
Published: December 2009

Protonation of isocyanides by salicylic acid or 3-hydroxy-2-naphthoic acid followed by addition of the conjugate anion of the acid to the resulting nitrilium cation and subsequent cyclisation of the iminoester intermediate formed leads to benzo or naphtho-fused 2-(alkylamino)-1,3-dioxin-4-one derivatives in excellent yields.
C1-Symmetrical Ti(OTos)2- and TiCl2-TADDOLate-catalysed 1,3-dipolar cycloaddition reactions of nitrones to electron-deficient alkenes
Authors: Wang Yan-xia , Zhu Yong-kuan , Liu Bo , You Jun , Liu Nan
Published: December 2009

A regio-, diastereo- and enantioselective 1,3-dipolar cycloaddition reaction between nitrones and electron-deficient alkenes has been developed employing C1-symmetrical Ti(OTos)2- and TiCl2-TADDOLate as catalysts. In the presence of powdered 4 Å molecular sieves and 100 mol% of Ti(OTos)2-TADDOLate as the catalyst, the nitrones smoothly react with alkenes at room temperature to give isoxazolidines in high conversion, giving the trans-diastereomer of the isoxazolidines with de's up to >90% and ee up to 58%. Furthermore, C1-symmetrical TiCl2-TADDOLate has a better chiral induction, giving the trans-diastereomer of the isoxazolidines with high enantioselectivity up to 70% ee. The influence of catalyst amount, temperature and solvents on the reaction course has been investigated
Four new butanolide derivatives from hortonia, a genus endemic to Sri Lanka
Authors: Ratnayake Rukmal , Bandara B.M. Ratnayake , Wijesundara D. Siril. A. , Carr Gavin , Andersen Raymond J. , Karunaratne Veranja
Published: December 2009

Three new butanolides, (2E,3R,4R,9′Z)-2-(dodec-9′-en-11′-ynylidene)-3-hydroxy-4-methylbutanolide (1), (2E,3R,4R)-2-(dodeca-9′,11′-diynylidene)-3-hydroxy-4-methylbutanolide(2),(2E,3R,4R,9′E)-2-(dodeca-9′,11′-dienylidene)-3-hydroxy-4-methylbutanolide (3) and one new ring-opened butanolide, methyl (2Z,11Z,1′R,2′R)-2-(1′,2′-dihydroxypropyl) tetradeca-2,11-dien-13-ynoate (4) were isolated from the leaves of the three representative species of the endemic primitive genus Hortonia (Monimiaceae), namely H. angustifolia, H. floribunda and H. ovalifolia. Their structures were elucidated on the basis of spectroscopic evidence.
Synthesis, characterisation, DFT and biomedical investigation of new Ga(III) complex with imidazole
Authors: Alhokbany Noura S M , Siddiqui M Rafiq H , Mahfouz Refat M
Published: December 2009

A new Ga(III) complex with imidazole (IMZ) in 1:2 Ga:IMZ stoichiometric ratio has been synthesised. The complex has been characterised by spectroscopic (IR, NMR, UV-Vis.,), thermogravimetric (TG, DTG, DTA), electrophoresis and microanalytical techniques and shown to be [GaCl(IMZ)2(H2O)]. The geometry of [GaCl(IMZ)2(H2O)] was optimised in a singlet state by the DFT method with B3LYP functional. Theoretical analysis of vibration modes of this complex has been undertaken and the results were compared with the experimental data for this compound. The complex was subjected to radiolabelling with 67Ga via the nuclear reaction 68Zn (p, 2n) 67Ga. The radiochemical yield was greater than 80%. HPLC analysis in isotonic systems revealed that this complex is highly unstable in an isotonic system where it readily dissociated. The investigated complex showed relatively high anti-bacterial activities compared with the free ligand.
Synthesis and reactions of 3-[3-(dimethylamino)propenoyl]-1,7-diphenyl [1,2,4]triazolo[4,3-a]pyrimidin-5(1H)-one
Authors: Farghaly Thoraya A.
Published: December 2009

3-Acetyl-1,7-diphenyl[1,2,4]triazolo[4,3-a]pyrimidin-5(1H)-one (1) reacts with N,N-dimethylformamide dimethylacetal (DMFDMA) yielding the enaminone 2. The latter compound reacts with active methylene compounds, hydrazine hydrate, hydroxylamine and some heterocyclic amines to afford trisubstituted pyridine, substituted pyrazole, substituted isoxazole and azolopyrimidines. The antimicrobial activities of the compounds prepared were screened.
Synthesis of N-formylmaleamic acid and some related N-formylamides
Authors: Behrman Edward J. , Hillenbrand Edward L.
Published: December 2009

Two syntheses of N-formylmaleamic acid and some related N-formylamides are described which take place under very mild conditions.
Synthesis, Spectroscopy and Crystal Structure of 2-cyclohexyl-5-formyl-6-(4-bromophenyl)imidazo[2,1-b][1,3,4]thiadiazole
Authors: Begum Noor Shahina , Vasundhara D.E. , Kolavi G.D. , Gowda K.V. Arjun , Khazi I.M.
Published: December 2009

The preparation of 2-cyclohexyl-5-formyl-6-(4-bromophenyl)imidazo[2,1- b][1,3,4]thiadiazole (3) is described and its crystal structure is determined and discussed.
Thermal oxidation of tetracyclones (2,3,4,5-tetraarylcyclopentadienones)
Authors: Thiemann Thies , Iniesta Jesus , Walton David J.
Published: December 2009

Tetracyclones are transformed to a mixture of diacylstilbenes and α-pyrones, when they are heated in diphenylether saturated with oxygen.
Dipyridine Cobalt Chloride: A Novel Catalyst for the Synthesis of Coumarins via Pechmann Condensation
Authors: Madhav Janganati Venu , Kuarm Bowroju Suresh , Someshwar Pola , Rajitha Bavanthula , Reddy Yerram Reddy Thirupathi , Crooks Peter A.
Published: December 2009

Dipyridine cobalt chloride is a novel catalyst for the Pechmann condensation involving different phenols and ethylacetoacetate under solvent-free conditions using both conventional methods and microwave irradiation. It gives the corresponding coumarins in excellent yields with high purity. The catalyst is thermally stable, inexpensive and recyclable. A faster reaction and higher yields compared to the conventional method and no side products were identified using microwave irradiation. In this reaction, electron releasing groups on the phenol ring shown more reactivity and gave high yields than simple phenol. These products were identified by 1H NMR, 13C NMR, MS, IR and elemental analysis.
A Novel Alkaloid from the Seeds of Daphniphyllum calycinum
Authors: Tang Lan , Rao Gui-Wei , Zhan Zha-Jun , Shan Wei-Guang
Published: December 2009

One novel alkaloid, named as caldaphnidine G (1), and two known alkaloid calycicine A (2), daphnezomine L (3) were isolated from the seeds of Daphniphyllum calycinum. The structure of 1 was established by spectral methods, especially 2D NMR techniques.
Synthesis, Crystal Structure and Properties of [Gd(C6NO2H5)3(H2O)2]n (1.5nZnCl4)·nH2O with Unprecedented Poly-Cationic Chains
Authors: Chen Wentong , Yao Zhongliang , Huang Jinshun , Liu Dongsheng , Ying Shaoming , Liu Jiuhui
Published: December 2009

A new heterometallic 4f-3d inorganic-organic metal-nicotinic acid complex [Gd(C6NO2H5)3(H2O)2] n(1.5 nZnCl4) nH2O, (1), has been synthesised via hydrothermal reaction and structurally characterised. Complex 1 crystallises in the space group P21/ c of the monoclinic system with four formula units in a cell: a = 9.524(2), b = 20.888(4), c = 16.078(3) Å β = 104.745(2)°, V= 3093.2(9) Å3, C18H21Cl6GdN3O9Zn1.50, M r=891.38 g/mol, D c= 1.914 g/cm3, S = 0.997, μ(MoKα) = 3.844 mm1, F(000) = 1732, R = 0.0493 and wR = 0.1350. Complex 1 is characteristic of a one-dimensional polycationic chain-like structure. Photoluminescent investigation shows that the title complex displays strong emission in the blue region, which is attributed to the intraligand π–π* transition of nicotinic ligands. Optical absorption spectra of 1 reveal the presence of a wide optical bandgap of 3.73 eV.
Surface Mediated Synthesis of Unsymmetrical O,O-dialkyl Alkyl Pyrophosphonates using Neutral Alumina: Potential Chemical Weapons Convention Related Compounds
Authors: Kumar Rajesh , Dubey Devendra K. , Gupta Arvind K. , Kaushik M.P.
Published: December 2009

The surface mediated synthesis of unsymmetrical O,O’- dialkyl alkyl pyrophosphonates from O-alkyl alkylphosphonic acid is described. These pyrophosphonates are listed in schedule 2B4 of Chemical Weapon Convention (CWC). The effect of the presence of chromatographic grade of Al2O3on the phosphorylation of a series of alkyl phosphonic acids has also been investigated. For phosphonic acids having different alkyl groups, it was observed that higher yields of the more hindered pyrophosphonates were formed in the presence of Al2O3. This method has an advantage over the conventional methods in terms of easy work-up, reduced reaction time and high yields.
Synthesis and Catalytic Activities of (S)-1-formylpyrrolidine-2-carboxylic Acid Derivatives for the Enantioselective Reductions of Both a Ketone and a Ketimine
Authors: Chen Zhenfei , Zhang Anjiang , Zhang Lixue , Zhang Jing , Lei Xinxiang
Published: December 2009

A series of ( S)-1-formylpyrrolidine-2-carboxylic acid derivatives (6a–t) have been synthesised and examined as chiral organocatalysts in the asymmetric reduction of both ketone 2 and ketimine 3. These organic activators afforded good to moderate enantioselectivities in the asymmetric reductions of both the ketone and the ketimine. Among them, organic activator 6h displayed the best efficiency, affording a 84% yield and 41% ee in the reduction of the ketone and 75% yield and 52% ee in the reduction of the ketimine.
Sc(OTf)3-Catalysed Ring-Opening of Aziridines with Phenol Derivatives Under Solvent-Free Conditions
Authors: Chen Ren'er , Xie Ting , Jin Can , Su Weike
Published: December 2009

Scandium(III) triflate-catalysed ring opening of aziridines with phenol derivatives affords various 2-amino ethers 3 (eg 4-methyl- N-(2-phenoxy-2-phenylethyl) benzenesulfonamide) with high regioselectivity and high yields under solvent-free conditions. The unexpectedly rearranged product 4 (e.g. 4-methyl-N-(3-methyl-3-phenoxy butyl) benzene sulfonamide) was obtained when 2-isopropyl- N-tosylaziridine was the substrate.
Liquid-Phase Organic Synthesis of imidazo[1,2-a]pyridine Derivatives Using PEG-Supported Sulfonyl Chloride
Authors: Wang Chao-Li , Sheng Shou-Ri , Chen Hu , Liu Xiao-Ling , Cai Ming-Zhong
Published: December 2009

Reaction of PEG-bound sulfonic acid with thionyl chloride formed the difunctionalised PEG-supported sulfonyl chloride, which was treated with α-hydroxyketones, followed by treatment with 2-aminopyridine in the presence of potassium carbonate efficient to afford imidazo[1,2- a]pyridines in good yields with a facile work-up procedure.
Microbiological Hydroxylation of Some Epoxy Steroids by the Fungus Mucor Plumbeus
Authors: Alfooty Khalid O.
Published: December 2009

The preparation of epoxy steroids derived from testosterone, dehydroisoandrosterone and epiandrosterone using m-chloroperbenzoic acid and their biotransformation by the fungus Mucor plumbeus is described. The results reveal an effect of the epoxide on the biotransformation.
A Novel Bisbenzylisoquinoline Alkaloid from Lindera Aggregata
Authors: Gan Lishe , Zhao Xia , Yao Wei , Wu Limao , Li Lianda , Zhou Changxin
Published: December 2009

A novel bisbenzylisoquinoline alkaloid, linderegatine (1), as well as two known isoquinoline alkaloids (+)-reticuline (2) and pallidine (3) were isolated from the roots of the Chinese medicinal plant Lindera aggregata. Their structures were determined on the basis of extensive spectroscopic studies.
Electrophilic Aromatic Substitution of 7-f-butyl-1,3-dimethylpyrene: Preparation of 5-mono- and 5,9-di-substituted 7-f-butyl-1,3-dimethylpyrenes
Authors: Hu Jian-yong , Paudel Arjun , Yamato Takehiko
Published: December 2009

Formylation and acetylation of 7- t-butyl-1,3-dimethylpyrene selectively afforded the 5-mono- and 5,9-di-substitution products depending on the Lewis acid catalyst used, while bromination and nitration afforded the 6-substitution product.
Synthesis of Aryl Thiocyanates using Al2O3/MeSO3H (AMA) as a Novel Heterogeneous System
Authors: Hosseini-Sarvari Mona , Tavakolian Mina
Published: December 2009

Indoles and various aromatic and heteroaromatic compounds undergo smooth thiocyanation with ammonium thiocyanate in the presence of a mixture of Al2O3/MeSO3H (AMA) under mild conditions without use of any organic solvents to afford the corresponding aryl thiocyanates in excellent yields and with high selectivity. The reactions proceed rapidly at room temperature.
Control of Conformational Flexibility in Calix[6]Arenes: Synthesis and Characterisation of Triply Bridged Calix[6]Arene–-10,15-Dihydro-5H-Tribenzo [a,d,g]Cyclononene Conjugates
Authors: Chawla H. Mohindra , Shrivastava Rahul
Published: December 2009

A series of triply bridged symmetrical tert-butylcalix[6]arene–-10,15-dihydro-5 H-tribenzo[ a,d,g]cyclononene conjugates have been synthesised in excellent yields. It has been observed that the synthesised multi-cavity molecular receptors retain the calix[6]arene and derivatised 10,15-dihydro-5 H-tribenzo[ a,d,g]cyclononene units in their cone conformations in solution. While the employed alkyl spacers confer flexibility to the conjugate units at room temperature, the synthesised receptors have been observed to exist in flattened cone conformations at low temperatures as determined by variable temperature NMR measurements. It has been observed that 6b shows a significant selectivity towards Ba2+ over other metal ions while compound 6c shows selectivity towards NH4+ ions from amongst alkali, alkaline-earth and transition metal picrates. Alkali and transition metal ions are poorly extracted by the hosts 6a–c. The extraction abilities of host molecules 5a–c towards metal picrates were found to be much less than that of 6a–c.
An Efficient Synthesis of N,N-bis[2-(2-nitrophenylamino)ethyl]glycine Glycosyl Esters and Antiviral Activity
Authors: Chen Hong , Huang Si-Qing , Xie Jian-Ying
Published: December 2009

N,N-bis[2-(2-nitrophenylamino)ethyl]glycine glycosyl esters were synthesised in good yields at room temperature using DMAP/Et3N. All of the new synthesised compounds were of β-configuration. The compounds show good antiviral activity against tobacco mosaic virus(TMV).
Regio- and Stereoselective Synthesis of α,β-dehydro-β-amino Esters
Authors: Li Dafeng , Li Jian , Jia Xueshun
Published: December 2009

A facile method for the regio- and stereoselective synthesis of α,β-dehydro-β-amino esters from acetates of Baylis-Hillman adducts with amines was reported. In the absence of any solvent and catalyst, the present strategy works well for a series of electron deficient and electron rich aromatic amines as well as aliphatic ones.
The Rotation of the Nitro and Formyl Groups Relative to the Aromatic Ring in Some ortho-nitroarylaldehydes
Authors: Hanson James R. , Hitchcock Peter B. , Toche Francois
Published: December 2009

X-Ray crystallographic studies have shown that in ortho-nitroarylaldehydes the plane of an aryl nitro group is rotated relative to the aromatic ring to a greater extent than that of the adjacent formyl group.
Thermodynamic Studies of Dissociation Reactions of Some Dicarboxylic Acids in 20% (w/w) Acetonitrile - Water Mixture
Authors: Younes Ghassan
Published: December 2009

p K1 and p K2 values at zero ionic strength of some dicarboxylic acids (succinic, tartaric, malonic, malic and maleic) in 20% (w/w) acetonitrile-water at temperatures ranging from 30 °C to 60 °C have been determined using a precise EMF method. The thermodynamic parameters Δ H°, Δ G° and Δ S° of the first and the second dissociation reactions are calculated from well known equations and discussed in terms of solute-solvent interactions. An extrathermodynamic analysis of the obtained results has been performed and indicates that these dissociation reactions are entropy-controlled reactions where solute-solvent interaction plays an important role.
Synthesis of Substituted Styrenes and Stilbenes Mediated by Palladium on Zirconia
Authors: Borate Hanumant B. , Dumbre Deepa K. , Wakharkar Radhika D. , Choudhary Vasant R.
Published: December 2009

Palladium on zirconia has been found to be an effective catalyst for the synthesis of various substituted styrenes and stilbenes, including biologically active natural products, by reaction of aryl halides with olefins.
Convenient Synthesis of 2-pyridyl thioglycosides
Authors: Elgemeie Galal , Eltamny Elsayed , Elgawad Ibraheim , Mahmoud Nashwa
Published: December 2009

A reported method for preparation of a new class of pyridine thioglycosides via reaction of pyridine-2(1 H)-thiones with 2,3,4-tri- O-acetyl-α-d-xylo- and -β-d-arabinopyranosyl bromides has been studied.
Synthesis and Crystal Structure of 1,2-dihydro-1-(4-chlorophenyl)naphtho [1,2-e][1,3]oxazin-3-one
Authors: Khavasi Hamid Reza , Bazgir Ayoob , Amani Vahid , Rahimi Rahmatollah
Published: December 2009

1,2-dihydro-1-(4-chlorophenyl)naphtho[1,2- e][1,3]oxazin-3-one, C18H12ClNO2, was prepared from β-naphthol, 4-chlorobenzaldehyde, urea and acetic acid and its structure elucidated by X-ray diffraction method.
Uses of Piperonal in the Synthesis of Novel Prop-2-Enoyl Amides, Esters, Heterocyclic Systems and Study of their Antibacterial Activities
Authors: Shiba Sayed A. , El-Ziaty Ahmed K. , El-Aasar Nadia K. , Al-Saman Hana'a A.
Published: December 2009

Novel ( E)-3-(benzo[d][1,3]dioxol-5-yl)-2-cyanoacryloyl chloride 4 was condensed with several mono-; 1,2-; 1,3- and 1,4-bi-nucleophilic reagents containing nitrogen and oxygen to give new 2-propenoylamide and ester derivatives. Some of these amides cyclised under the reaction conditions and/or with POCl3 to give new derivatives of heterocyclic systems. Antibacterial activities were tested for nine of these products.
A Three-Component Synthesis of N-Substituted Quinoline- 3-Carbonitrile Derivatives Catalysed by L-Proline
Authors: Shi Chunling , Chen Hui , Li Yan , Shi Daqing , Ji Min
Published: December 2009

A series of new N-substituted quinoline-3-carbonitrile derivatives were synthesised by the three-component reaction of N-substituted 5,5-dimethyl-3-aminocyclohex-2-enone, an arylaldehyde, and malononitrile catalysed by l-proline in ethanol at 80°C.
Dicobaltbisnorbornadienetetracarbonyl [Co2(Nbd)2(CO)4] Reacts with Oxygen-Containing Alkynes and Gives Crossover Products in the Presence of other Alkenes
Authors: Coogan Michael P. , Wilkins Derek S.
Published: December 2009

Dicobaltbisnorbornadienetetracarbonyl, [Co2(nbd)2(CO)4] DDTC, (nbd = norbornadiene) which has previously been reported to be unreactive with alkynes is shown to react with oxygen-containing alkynes; in the presence of other alkenes crossover reaction is seen which has important implications for the mechanism of this, and possibly other, reactions.
Stereoselective Synthesis of Vinyl Sulfones by the Stille Coupling of (E)-α-Stannylvinyl Sulfones with Aryl Halides
Authors: Hu Ronghua , Yu Yan , Cai Mingzhong
Published: December 2009

Palladium-catalysed hydrostannylation of acetylenic sulfones (R–C≡C–SO2Ar) in benzene at room temperature gives stereoselectively (E)-α-stannylvinyl sulfones in good to high yields. (E)-α-Stannylvinyl sulfones are difunctional group reagents which undergo Stille coupling reaction with aryl halides in the presence of Pd(PPh3)4 and CuI co-catalyst to afford stereoselectively (Z)-1,2-disubstituted vinyl sulfones in good yields.
Structure and photochemical properties of biindenylidene derivatives in the solid state
Authors: Li Xu , Wang Ping , Liu Jing-jun , Wang Yong-ming , Zhu Hai
Published: December 2009

Two photochromic compounds, trans-3,3′-dipentyl-3,3′-dihydroxy-2,2′-bi-1H-indene-1,1′-dione (I), and cis-3,3′-di (2-methylally)-3,3′-dihydroxy-2,2′-bi-1H-indene-1,1′-dione (II), were synthesised and their crystal structures were determined by X-ray crystallography. The photoinduced properties of the compound were studied. The results showed that compound I exhibited reversible photochromism, and at the same time a stable organic radical was generated, while compound II did not show photochemical properties.
Chlorination of 3-substituted sydnones using 1,4-dichloro-1,4-diazoniabicyclo[2,2,2]octane bis-chloride
Authors: Salmanpoor Sadegh , Tajbakhsh Mahmood , Habibzadeh Setareh , Azarifar Davood , Ghasemnejad-Bosra Hassan
Published: December 2009

1,4-Dichloro-1,4-diazoniabicyclo[2,2,2]octane bis-chloride has been used as effective reagent for the chlorination of 3-arylsydnones to their corresponding 4-chloro derivatives in DMF-H2O at room temperature. The 1,4-diazabicyclo [2,2,2]octane was regenerated, rechlorinated and reused several times.
Synthesis of Alkyl 2-[2-oxopyridin-1(2H)-yl]acrylates by Nucleophilic Addition of Alkyl Propiolates Catalysed by Ph3P
Authors: Mohtat Bita , Jabbar Sepideh , Ghasemi Abdollah , Yavari Issa
Published: December 2009

2-Hydroxypyridine undergoes a smooth reaction with alkyl propiolates in the presence of triphenylphosphine (15 mol%) to produce the corresponding alkyl 2-[2-oxopyridin-1(2H)-yl]acrylates in good yields. When the reaction was performed by 2-hydroxyquinoline and 2-hydroxyisoquinoline similar α-substituted alkyl acrylates were obtained.
The synthesis and spectral properties of novel porphyrazines with eight (p-tolylmethylthio) and (o-tolylmethylthio) units
Authors: Cenan Neslihan , Gonca Ergün
Published: December 2009

By cyclotetramerisation of 1,2-bis(p-tolylmethylthio) and 1,2-bis(o-tolylmethylthio) maleonitrile in the presence of magnesium butanolate, magnesium porphyrazinates carrying eight (p-tolylmethylthio) and (o-tolylmethylthio) units on the peripheral positions have been synthesised. Conversion of the magnesium porphyrazinates into the metal-free derivatives was achieved by treatment with trifluoroacetic acid. Further reactions of these products with copper(ll) acetate, zinc(ll) acetate and cobalt(ll) acetate led to the metal porphyrazinates (M = Cu, Zn, Co).
Synthesis of fluorinated β-carbolines by one-pot reaction
Authors: Cai Mingtiao , Chen Jiuxi , Huang Xiaobo , Liu Miaochang , Ding Jinchang , Wu Huayue
Published: December 2009

This paper describes a new strategy for the synthesis of 1-trifluoromethyl-9H-pyrido [3,4-b]indole 2 by one-pot reaction of tryptophan methyl ester hydrochloride 1 and trifluoroacetic anhydride (TFAA) in the presence of POCI3 with satisfactory yield. Additionally, the structure of 2b was confirmed by X-ray crystallographic analysis.
Site selectivity in reaction of hydrazonoyl halides with 2-(aroylmethyl)-6-methylpyrimidin-4(3H)-ones
Authors: Shawali Ahmad S. , Farghaly Thoraya A.
Published: December 2009

Reaction of hydrazonoyl halides 1 with 2-(aroylmethyl)-6-methylpyrimidin-4(3H)-ones 3 proved to be site selective and gave 2-(3-acetyl-1,5-diarylpyrazol-4-yl)-6-methylpyrimidin-4(3H)-ones 5 via dehydrative cyclisation of the hydrazone intermediates 4. The structures of both 4 and 5 were elucidated by spectral data and alternative synthesis. The mechanism of the reaction was discussed.
3,3,9,9-Tetramethyl-1,5,7,11-tetraoxaspiro[5.5]undecane as a reagent for protection of carbonyl compounds
Authors: Rahimizadeh Mohammad , Bakavoli Mehdi , Shiri Ali , Eshghi Hossein , Saberi Sattar
Published: December 2009

3,3,9,9-Tetramethyl-1,5,7,11-tetraoxaspiro[5.5]undecane is introduced as a new, stable and chemoselective reagent for the protection of aldehydes and ketones under mild reaction condition in high yield.
Ionic liquid-accelerated N-arylation of 5-arylidene-2,4-thiazolidinediones with diaryliodonium salts
Authors: Yang De-Hong , Gao Hong-Liang , Yang Ben-Yong , Chen Zhen-Chu
Published: December 2009

An efficient method for the synthesis of N-aryl-5-arylidene-2,4-thiazolidinediones has been developed involving the N-arylation of 5-arylidene-2,4-thiazolidinediones derivatives with diaryliodonium salts in the ionic liquid [bmim]PF6 (1-butyl-3-methylimidazolium hexafluorophosphate).
Synthesis and screening of quinolone antibiotic isosteres
Authors: Shaban Mohamed A. , Badry Ossama M. Al , Kamal Aliaa M. , El-Gawad Mohamd Abd el Wahap Abd
Published: December 2009

Condensation of either 4-(benzothiazol-2-yl)phenylamine 1 or 4-amino-2-(benzothiazol-2-yl)-phenol 2 with ethyl cyanoethoxyacrylate or diethyl ethoxymethylenemalonate (EMME) followed by intra molecular thermal cyclisation results in substituted quinolones which upon alkylation then base-hydrolysis yielded the target compounds 6-(benzothiazol-2-yl)-1-alkyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (3a,b); 7-(benzothiazol-2-yl)-1-alkyl-4-oxo-1,4-dihydro-6-alkoxyquinoline-3-carboxylic acid (4a,b). Meanwhile diazotisation of 4-(benzothiazol-2-yl)phenylamine (1) followed by reaction with malononitrile then intra molecular Friedel-Crafts acylation gave 4-amino-6-(benzothiazol-2-yl)cinnoline-3-carbonitrlie 5. The antimicrobial activity of some of the target compounds using gram-positive microbes (Staphylococcus aureus and Bacillus subtilis) and gram-negative bacteria (‘Escherichia coli and Pseudomonas aeruginosa) is carried out and 6-(benzothiazol-2-yl)-1-alkyl-4-oxo-1,4-dihydro quinoline-3-carboxylic acid (3a,b) and 7-(benzothiazol-2-yl)-1-alkyl-4-oxo-1,4-dihydro-6-alkoxyquinoline-3-carboxylic acid (4a,b) showed promising activity.
Synthesis, fluorescence properties and Zn2+ recognition of 4-Aryl-6-phenylpyrimidin-2(1H)-one
Authors: Wu Hui , Chen Xiu-mei , Wan Yu , Ye Ling , Xin Hai-qiang , Xu Hua-hong , Pang Li-ling , Ma Rui , Yue Cai-hui
Published: December 2009

4-Aryl-6-phenylpyrimidin-2(1H)-ones were synthesised via a three-component one-pot cyclocondensation of aromatic aldehyde, acetophenone and urea catalysed by 0.2 ml (0.024 mol%) of concentration HCI in ionic liquid [BMIM][BF4]. The fluorescence properties of product and partial products’ efficient sensing of zinc ion were studied in detail. The structure of 4,6-diphenylpyrimidin-2(1H)-one was confirmed by X-ray analysis.
Synthesis of 5,5′-(arylmethylene)bis(pyrimidinone) derivatives in aqueous media
Authors: Shi Da-Qing , Niu Li-Hui , Zhuang Qi-Ya
Published: December 2009

The condensation and addition reactions of aromatic aldehydes and 4,6-dihydroxypyrimidine or 2,4-dihydroxy-6-aminopyrimidine in water in the presence of triethylbenzylammonium chloride (TEBAC) afford a one-pot synthesis of 5,5′-(arylmethylene)bis[6-hydroxypyrimidine-4(3H)-one]s and 5,5′-(arylmethylene)bis[6-aminopyrimidine-2,4 (1H,3H)-dione]s. These compounds were characterised by elemental analysis and IR and 1H NMR spectra and further confirmed by a single crystal X-ray diffraction analysis.
The Schenck Rearrangement of Allylic Hydroperoxides
Authors: Davies Alwyn G
Published: December 2009

It is 50 years since Schenck's discovery of the ubiquitous rearrangement of allylic hydroperoxides, and its unique homolytic mechanism has now been clarified by a combination of experimental and computational methods. The recognised examples of the reaction are surveyed and the way in which the present mechanistic picture has emerged is reviewed. A brief account is given of the closely related Smith epimerisation of allylic hydroperoxides.
Control of III/VI Ratios in the Preparation of ln2Se3 thin Films
Authors: Ko Cheng-Hao , Chen Chang-Tai , Chen Nien-Po , Yang Ming-Der , Shen Ji-Lin , Lan Shan-Ming
Published: December 2009

CuInSe2 (CIS) thin films on glass substrates were successfully grown by the metal organic chemical vapour deposition method by using three precursors [Cu-precursor, trimethyl-indium (TMI) and hydrogen selenide (H2Se)]. The flow rates of TMI and H2Se can be adjusted independently to gain different lll/VI ratios, which is different from the single-precursor technique. Good chalcopyrite phase from CIS films was demonstrated by X-ray diffraction. The optical band gap of CIS thin films can be adjusted by controlling the growth conditions.