bluuebunny/crossref_metadata_2025 huggingface dataset:
La investigación colaborativa de las prácticas digitales: entre el usuario nodo y el mediagrama
Authors: Amancay Venega Sofía , Eisner Laura , Cantamutto Lucía
Published: December 2021

El objetivo es analizar la adaptación de la propuesta teórica del esquema usuario como nodo de interacciones (Yus, 2007), en tanto herramienta metodológica de producción colaborativa de datos, en una investigación de corte etnográfico sobre las prácticas comunicativas de adultas mayores. En el estudio, se articuló el usuario-nodo con el mediagrama, propuesto desde la sociolingüística como instrumento de recolección de datos. La implementación permitió graficar la integración de las tecnologías en las prácticas e interacciones con diferentes interlocutores y según el ámbito de uso, dando lugar a procesos reflexivos de las participantes y la producción de nuevos datos derivados de la visualización.
Un precario álbum familiar: la fotografía en Ordesa de Manuel Vilas
Authors: Venzon Ruben
Published: December 2021

Ordesa (2018) de Manuel Vilas es una novela de corte autoficcional que, mediante una estructura sumamente fragmentaria e híbrida, aborda el tema íntimo del duelo por la muerte de los padres. Para ello, el autor también recurre a la intermedialidad, reproduciendo documentalmente a lo largo de la narración algunas fotos extraídas de su álbum familiar. Este artículo explica la importancia de las fotografías en la construcción del relato y analiza su función dentro del texto de acuerdo con la relación entre palabra e imagen.
Federico en carne viva: un cisma en el discurso del dramaturgo José Moreno Arenas.
Authors: Escabias Toro Juana Natividad
Published: December 2021

Este artículo indaga en los mecanismos creativos más recónditos del dramaturgo José Moreno Arenas en relación con la concepción y elaboración de su última obra, Federico, en carne viva. La pieza supone un giro de ciento ochenta grados en el estilo de este veterano autor, una absoluta transformación de su escritura teatral que demanda una rigurosa observación y análisis. La semiótica y determinados conceptos que emergen de ella se presentan como la mejor herramienta para la tarea.
HACIA UNA HISTORIA CON MEMORIA. LA MEMORIA HISTÓRICA EN LA PROVINCIA DE PALENCIA
Authors: García Colmenares Pablo
Published: December 2021

En la enseñanza de la Historia cada vez está más presente la memoria como conocimiento de hechos que las fuentes tradicionales no recogían, especialmente en lo que se refiere a la represión y el uso de la violencia para la eliminación de los vencidos. La memoria les da voz, pero no sólo eso, sino que nos pone ante la tesitura de revisar la forma de hacer historia basada en la evolución de las sociedades, en su progreso sin analizar todo lo que se sacrificaba en aras del supuesto avance de la civilización humana. La memoria no sólo nos hace reflexionar y revisar el pasado, sino que se convierte en un método de trabajo, de investigación en el aula, ya que desde las fuentes orales los estudiantes pueden participar activamente en la formación de su conciencia histórica, para interpretar el pasado y entender mejor el presente y no cometer las mismas barbaridades en el futuro. Cada vez, en más provincias de España, tenemos lugares de la memoria simbólicos, con memoriales levantados al efecto, como para poder realizar itinerarios de memoria que nos permitan entender nuestro pasado más reciente y traumático durante la Guerra Civil y el franquismo.
FORESIGHT AS A METHOD FOR DESIGNING THE EDUCATIONAL ENVIRONMENT OF A UNIVERSITY
Authors: Dallaqyan Armine
Published: December 2021

The article presents a feature of the process designing the educational environment of a university, an innovative and effective method which is the Foresight- method.This method allows you to identify trends and conditioning factors and prepare the future of educational process of the university based on possible scenarios.
FEATURES OF CHILDREN'S LANGUAGE AND COMMUNICATION CAPACITIES IN THE MEDIA ENVIRONMENT
Authors: Manukyan Armenuhi , Danielyan Gayane
Published: December 2021

The article presents the results of observing the peculiarities of children's lan-guage thinking and communication skills development in the media environment, based on which we conclude that it is a multifaceted and complex process that has always ex-isted in various fields of science: pedagogy, media education, psychology, linguistics, linguistics, linguistics, linguistics. in the focus of specialists' interests. There is a belief that the main issue being examined by experts in these fields is that in the digital world, the development and manifestation of children's language thinking and communication skills takes place in the conditions of conscious and subconscious mutual agreement.
FAVORABLE PEDAGOGICAL CONDITIONS FOR PROVIDING AN EDUCATIONAL ENVIRONMENT, IMPLEMENTED IN INCLUSIVE SCHOOLS
Authors: Martirosyan Naira
Published: December 2021

The article is devoted to universal exclusive education and the environment. Achieving a healthy environment requires competent teachers and teacher aides, a posi-tive attitude, and the material and technical resources. Providing an enabling environ-ment is very important, which begins with the attitude of educators (heart), skill, skill (hand) and knowledge (head) - the manifestation of the trinity.
Determinants of farmland prices and their local variation
Authors: Lee Changro
Published: December 2021

The setting of farmland prices in the market not only reflects existing agricultural activities but also expected potential for development. This study decomposes farmland prices into values representative of current agricultural production and the prospective development potential at the county level in South Korea. The income value of farmland is derived by analysing agricultural revenue and production cost, and the sale value of farmland is estimated by reviewing transaction prices filed with the administrative authority. The difference between income value and sale value is adopted as the development value in this study. The results of the estimation show that the proportion of development value in the price of farmland is remarkably high, with a median proportion of 0.78, indicating that the threat of converting land to non-agricultural use is non-trivial because it remains a financially attractive alternative. In addition, the magnitude of the portion of the development value in the price of farmland varies considerably across counties depending on the distance to nearby metropolitan cities. This implies that agricultural policy should be designed in a locally optimised manner to effectively restrain the conversion of farmland for urban use.
Emergence of Socio-economic Geography and Spatial Management as a Scientific Discipline in the New Classification of Science in Poland1
Authors: Stryjakiewicz Tadeusz
Published: December 2021

The aim of the article is to present the chronology of activities that led to the emergence of the discipline ‘socio-economic geography and spatial management’ in the new classification of science in Poland which has been in force since 2018. The path of emergence of the discussed discipline is analysed from the standpoint of one of the participants of this process. The article also presents positive and negative consequences of implementing this classification in the context of two different structural models of geography as a science. Among positive consequences one can mention (1) preservation of the name ‘geography’ on the list of scientific disciplines, and (2) a favourable formal and legal ‘empowerment’ of socio-economic geography in the system of the organisation and evaluation of science in Poland. Among the greatest threats one can see (1) a reduction in the importance of socio-economic geography in favour of spatial management, and (2) the organisational disintegration of some geographical communities, institutions and research units. However, there are also attempts at the reintegration of geography around two of its basic segments, i.e. physical geography and human geography. In the author's opinion, future activities should focus on the means to strengthen realistically (and not only declaratively) the position of the new discipline and its constituent subdisciplines against other scientific disciplines.
Telerheumatology: A Narrative Review
Authors: Tang Wei , Khalili Leila , Askanase Anca
Published: December 2021

Telemedicine (TM), the delivery of health care using telecommunication technologies, has been in use in rheumatology practice for over two decades to maximize access and optimize care. As a direct consequence of the Coronavirus disease 2019 (COVID-19) pandemic in March 2020, rheumatology practice shifted from traditional in-person encounters to TM to ensure the safety of both healthcare professionals and patients. However, there is limited literature on the acceptance, feasibility, and effectiveness of TM in the management of rheumatic diseases. Additionally, there is limited guidance on the implementation of telerheumatology (TR) for both patient care and clinical trials. Here we reviewed the most recent publications related to the application of TR, in the management of Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE), assessed the perceptions of patients and physicians on TM in rheumatology, and identified several key barriers to TR.
Cardiovascular disease in systemic lupus erythematosus
Authors: McMahon Maureen , Seto Richard , Skaggs Brian J.
Published: December 2021

There is a well-known increased risk for cardiovascular disease that contributes to morbidity and mortality in systemic lupus erythematosus (SLE). Major adverse cardiovascular events and subclinical atherosclerosis are both increased in this patient population. While traditional cardiac risk factors do contribute to the increased risk that is seen, lupus disease-related factors, medications, and genetic factors also impact the overall risk. SLE-specific inflammation, including oxidized lipids, cytokines, and altered immune cell subtypes all are likely to play a role in the pathogenesis of atherosclerotic plaques. Research is ongoing to identify biomarkers that can help clinicians to predict which SLE patients are at the greatest risk for cardiovascular disease (CVD). While SLE-specific treatment regimens for the prevention of cardiovascular events have not been identified, current strategies include minimization of traditional cardiac risk factors and lowering of overall lupus disease activity.
A case report of a patient with parathyroid carcinoma and a CDC73 germline mutation
Authors: Raposo Nuno Cordeiro , Bala Nádia Mourinho , Pratas Sónia , Valadas Cristina
Published: December 2021

Background:

Parathyroid carcinoma (PC) is an uncommon cause of primary hyperparathyroidism (pHPT). Mutations of the cell division cycle protein 73 homolog (CDC73) gene are associated with both sporadic and familial pHPT and PC, including hyperparathyroidism-jaw tumor (HPT-JT) syndrome.

Case Presentation:

A 38-year-old man presented with severe hypercalcemia and acute renal injury due to pHPT. He had a palpable left cervical mass of 50 mm, characterized by both ultrasound and 99mTc-sestamibi scintigraphy as an enlarged hyperfunctioning parathyroid gland. Histological diagnosis after parathyroidectomy was of PC. During follow-up patient developed metastasis of the skin, mediastinal lymph-nodes, and lungs. Even after surgical excision of all detectable metastasis parathyroid hormone (PTH) remained elevated. Genetic analysis found a germline mutation (c.766_767delGT) of the CDC73 gene, which was not previously reported in PC.

Conclusion:

Germline CDC73 analysis may be considered in HPT-JT syndrome, familial isolated pHPT, PC, and young individuals with pHPT.
COVID-19 prevalence and infection control measures at homeless shelters and hostels in high-income countries: a scoping review
Authors: Levesque Justine , Babando Jordan , Loranger Nathaniel , Johnson Shantel
Published: December 2021

Background: The COVID-19 pandemic has disproportionately impacted homeless populations and service workers, especially within homeless shelter/hostel settings. To date, there have been few evidence syntheses examining outbreaks of COVID-19 among both homeless shelters residents and service workers, nor has there been a critically engaged summary of relevant infection control and prevention (IPAC) measures. This scoping review offers a timely and much-needed synthesis of COVID-19 prevalence within homeless shelters and a review of current and pertinent IPAC measures. Methods: We conducted a scoping review in June 2021 that synthesized academic and grey literature published from March 2020 to July 2021 pertaining to 1) the prevalence of COVID-19 among both residents and staff in homeless shelters and hostels in high-income countries, and 2) COVID-19 IPAC strategies applied in these settings. Two reviewers independently screened the results of the literature search of several databases that included MEDLINE, PsycInfo, and the WHO’s COVID-19 Global Health Portal. All the extracted data was mapped, categorized, and thematically discussed. Results: Thematic analysis of included literature revealed five key themes: 1) the demographics of COVID-19 in homeless shelters, 2) asymptomatic spread, 3) pre-existing vulnerability of the homeless and shelters, 4) the limited application of IPAC, and 5) IPAC effectiveness. Conclusion: This review offers a useful glimpse into the landscape of COVID-19 outbreaks in homeless shelters/hostels and the major contributing factors to these events. The scoping review revealed that there is no clear indication of generally accepted IPAC standards for homeless populations and shelter care workers. This review also illustrated a great need for future research to establish IPAC best practices as well as additional resources for shelter systems to protect residents and staff at homeless shelters/hostels in high-income countries. Finally, the findings from this review reaffirm that homelessness prevention is a key to limiting disease outbreaks, and the associated negative health outcomes in shelter populations.
Formation of the image of Buddhism in Russia (the end of the XIX – the beginning of the XX centuries)
Authors: Nesterkin Sergei
Published: December 2021

This article examines the sources of formation of the image of Buddhism in the Russian cultural environment and determine the degree of representativeness of this image. The author highlights the three main sources: 1) academic research works of the Western Schools of Buddhology (based on Pāli and Sanskrit material); 2) research conducted within the framework of the Russian School of Buddhology (based primarily on Tibetan- and Mongolian-language material); 3) research of the Orthodox Russian missionaries. It is determined that the fundamental theoretical position developed by the Anglo-Germanic School of Buddhology is the thesis on authenticity of Theravada Buddhism, which is considered as “initial”, and its other forms (such as Mahayana, Vajrayana) are considered as its later modifications that emerged under the influence of external factors. The key features of Buddhism in Buddhology imply that: 1) Buddha Shakyamuni was not a transcendent being; 2) his nirvana is understood nihilistically, as a complete cessation of the process of being; 3) Buddhism, denies the existence of soul; 4) the existence of God and the representation of the transcendent are also denied. Despite the fact that the studies of Mahayana and Vajrayana material indicated inadequacy of such assessment, these theses were reproduced over again. This is explained by the interest of significant social groups in such image of Buddhism: many Orthodox figures interpreted Buddhism as a philosophical-ethical, rather than religious system; atheistically-oriented scholars and scientifically-oriented public also supported such interpretation. The rational aspects of Buddhism, which give common grounds with science, were uncritically absolutized; Buddhism was viewed as an ally of scientific thinking, completely alien to faith.
Inspiracje ku radości na kanwie adhortacji Gaudete in Domino papieża Pawła VI
Authors: Nagel Zygmunt Jan
Published: December 2021

Radości możemy doświadczać na wielu płaszczyznach naszego życia. Łatwo radować się w sytuacjach, które bezpośrednio inspirują nas ku radości. Jednak zdecydowanie trudniej odkrywać radość w obliczu smutnych doświadczeń naszego życia, łącznie z cierpieniem i śmiercią. Niniejszy artykuł, inspirowany adhortacją Gaudete in Domino papieża Pawła VI, stanowi próbę ponownego spojrzenia na zagadnienie radości nie tylkona kanwie wspomnianej adhortacji, ale również innych dokumentów i wybranej literatury traktującej o radości. Niniejszy artykuł ukazuje najważniejsze inspiracje ku radości, które prezentuje papież Paweł VI, a które zostały poddane analizie i refleksji w kontekście współczesnych czasów, w których człowiek tak łatwo traci radość i sens życia.
Ethische Aspekte der Auswirkungen der Corona-Pandemie auf Beschäftigung und Soziales
Authors: Lintner Martin M.
Published: December 2021

Die Covid-19-Pandemie hat auf vielfältige Weise wie unter einem Brennglas gesellschaftliche Probleme aufgezeigt und zugleich verschärft. Und sie bewirkt und beschleunigt Transformationsprozesse, die besonders die Arbeitswelt und die Arbeitsbeziehungen betreffen. Der folgende Beitrag beleuchtet diese Aspekte in Bezug auf die „soziale Bruchlinie Geschlecht“ und zeigt auf, dass besonders Frauen in prekären Lebens- und Arbeitsverhältnissen von den sozialen Folgen der Pandemie betroffen sind. Auch wird der Aspekt der (weiterhin mangelnden) Anerkennung der Arbeit in den Pflegeberufen vertieft sowie die Frage gestellt, was unter „systemrelevanten“ Berufen zu verstehen ist. Schließlich wird das unter anderem auch von Papst Franziskus erneut in die Diskussion gebrachte Thema des Grundeinkommens aufgegriffen als eine mögliche Maßnahme, um die negativen Folgen der Pandemie abzufedern und jene „systemrelevanten“ Aufgaben auch finanziell anzuerkennen, die derzeit vielfach nicht entlohnt werden. Den Abschluss bilden – ausgehend von Papst Franziskus – einige Überlegungen  zur Frage, wie der gesellschaftliche Zusammenhalt gestärkt werden kann und welche Veränderungen hierfür notwendig sind.
Hubungan Persepsi Pola Asuh Permisif Ayah dan Kecenderungan Perilaku Cyberbullying Remaja Usia 12-18 Tahun
Authors: Dewanti Cyntia Dewi , Purwanti Margaretha , Aisyah Aireen Rhammy Kinara
Published: December 2021

Cyberbullying among teenagers in Indonesia continues to increase, especially during this Covid-19 pandemic. One of the factors that trigger cyberbullying behavior in adolescents is the application of parenting. Permissive parenting is thought to have a relationship with the occurrence of cyberbullying. In parenting, fathers tend to be less involved even though they have a role that is no less important than mothers. Therefore, this researcher's question is whether the perception of permissive parenting is related to the tendency of cyberbullying behavior in adolescents aged 12-18 years. This research uses a quantitative approach with a correlational design and used a convenience sampling and obtained as many as 123 participants. The characteristics of the participants in this study were male/female aged 12-18 years who had social media and still had a father and still lived together. Results shows that there is a significant relationship between perceptions of permissive parenting and cyberbullying tendencies. The correlation results obtained are r = 0.580, p = < .001. This research concluded that increasing adolescents' perceptions of permissive parenting applied by fathers, the higher the tendency of adolescents to do cyberbullying.
On the Challenge Associated with the Final Stage of Irradiated Graphite Management from Water-Graphite NPP Reactor Units
Authors:   “Rosenergoatom Concern” JSC, Volkov V. G. , Safronova N. N. ,   “Rosenergoatom Concern” JSC, Morozov F. T. ,   “Rosenergoatom Concern” JSC, Komarov E. A. ,   State Corporation “Rosatom”, Zimin V. K. ,   JSC “Atomenergoproekt”, Bylkin B. K. ,   NRC “Kurchatov Institute”, Zverkov Yu. A. ,   NRC “Kurchatov Institute”, Pavlyuk A. O. ,   “Pilot & Demonstration Center for Decommissioning of Uranium-Graphite Nuclear Reactors”, JSC, Kotlyarevsky S. G. ,   “Pilot & Demonstration Center for Decommissioning of Uranium-Graphite Nuclear Reactors”, JSC, Kan R. I. ,   “Pilot & Demonstration Center for Decommissioning of Uranium-Graphite Nuclear Reactors”, JSC
Published: December 2021

The paper discusses engineering, economic and legislative aspects influencing the ways of addressing the problem associated with the final stage of irradiated graphite management from water-graphite NPP reactor units in Russia. It presents some calculated and experimental data demonstrating the feasibility of introducing some corrective changes to the legislative and regulatory framework existing in the Russian Federation to enable near-surface disposal of irradiated graphite from power reactors.
Regeneration of Metal Radioactive Waste from Radiochemical Industries for Metal and Alloy Recycling Purposes
Authors:   LLC “Corporation for Nuclear Containers”, Bychkov S. I. , Zhirnikov D. V. ,   FSUE “Mining and Chemical Combine”, Alekseenko V. N. ,   FSUE “Mining and Chemical Combine”, Matselya V. I. ,   FSUE “Mining and Chemical Combine”
Published: December 2021

The paper proposes a processing method for metal radioactive waste (high alloyed stainless steel and its alloys) containing transuranic radionuclides. This type of waste is generated during operation and decommissioning of SNF reprocessing equipment at radiochemical production facilities. To ensure the recycling of valuable components, decontamination and conditioning of the regenerated ingots to high-quality metal is arranged in a two-staged process involving MRW remelting: its first stage involves in-depth metal decontamination under a layer of a refining flux, whereas the second stage provides for additional metal treatment to remove radioactive and stable impurities, as well as metal alloying to make up for the "burnt out" valuable components and to level its chemical composition. The process is implemented at an enterprise specialized in RW processing having appropriate infrastructure facilities and licenses authorizing relevant operations with radioactive materials. Metal radioactive waste regeneration results in a grade metal, which in terms of its residual radioactive contamination level can be released from radiation control and admitted to unrestricted use. It has been experimentally demonstrated that ESR, when used for MRW decontamination purposes, allows to obtain high-quality steel suitable for future reuse.
Method for Radioactive Waste Disposal in Underground Mines
Authors:   JSC “Central Project and Technological Institut”, Fuel Division of Rosatom “TVEL”, Kuzmin E. V. , Kalakutsky A. V. ,   JSC “Central Project and Technological Institut”, Fuel Division of Rosatom “TVEL”, Morozov A. A. ,   PJSC “Priargunskoye Industrial Mining and Chemical Association named after E. P. Slavsky”
Published: December 2021

This paper presents the key parameters associated with the disposal method used to dispose of radioactive waste (RW) of Class 2 and 3 in abandoned underground mines of PIMCU site assuming additional isolation of RW containers, adjustment of bedrock geomechanical properties and compliance with regulatory requirements. The paper briefly analyzes international practices focused on RW disposal in natural and artificial underground cavities. It provides a comparison between the forecasted volumes of RW generation at the enterprises of the State Corporation Rosatom and the available underground disposal capacity at PIMCU site. It presents the main characteristics of a paste filling manufactured based on materials from uranium ore processing and used as an insulating filler inside the vaults. The paper summarizes the results of operations on rock mass reinforcement based on an injection method. It indicates the key advantages of the proposed method.
Issues of Establishing Standards for Radiation Safety of Wildlife Including the Radioactive Waste Management
Authors:   Research and Production Association “Typhoon”, Kryshev I. I. , Sazykina T. G. ,   Research and Production Association “Typhoon”, Arakelyan A. A. ,   Nuclear Safety Institute of the Russian Academy of Sciences, Vedernikova M. V. ,   Nuclear Safety Institute of the Russian Academy of Sciences, Panchenko S. V. ,   Nuclear Safety Institute of the Russian Academy of Sciences
Published: December 2021

Although some regulatory requirements are available in Russia to ensure and demonstrate the radiation safety of the environment including those covering the atomic energy sector, still no criteria establishing the safe levels of radionuclide concentrations in the environment have been approved by the Ministry of Natural Resources and Ecology of the Russian Federation. Threshold concentrations in the environment established to protect human health have been largely used as such criteria. The experience gained shows that in some cases due to the radioactive contamination of the environment, certain biological species received higher radiation doses compared to humans. In 2014, a methodology was developed to assess the radiation damage caused to the environment at RW storage facilities taking into account relevant international recommendations. Safe level of non-human biota exposure of 1 mGy/d was established for mammals, vertebrates and pine trees as a criteria providing favorable environment and radioecological safety, whereas relevant value for the rest of flora organisms and invertebrates was taken equal to 10 mGy/d. In 2016, Roshydromet approved the recommendations on a procedure developed to calculate the reference levels of radionuclide concentrations in the environmental components taking into account relevant testing methods. The experience gained from the testing of environmentally safe levels proposed in these papers can be used to develop and adopt environmental quality standards. In the near future, environmental quality standards should be developed and approved to implement the provisions of the Federal Law No. 7 and relevant decrees of the Government of the Russian Federation which will be aimed at preserving the wildlife and the gene pool of plants, animals and other living organisms.
Using hot isostatic pressing for radioactive waste isolation purposes
Authors:   JSC V. G. Khlopin Radium Institute, Pokhitonov Yu. A. , Starchenko V. A. ,   JSC V. G. Khlopin Radium Institute, Dalyaev I. Yu. ,   Federal State Autonomous Scientific Institution “Central Research and Development Institute of Robotics and Technical Cybernetics”, Titov S. L. ,   LLC Design Institute Petrohim–Technology
Published: December 2021

The paper summarizes the findings of a study focused on hot isostatic pressing (HIP) technique implemented by the Khlopin Radium institute. The equipment was designed and manufactured at the Kharkov’s Physics and Technology Institute. The installation provided a pressure of up to 400 NPa with the pressing temperature of up to 1250°C. The experiments were carried out on installations located in hot cells in the radiochemical department (Gatchina city). Samples of materials for HLW immobilization (titanate ceramics of the synroc type, stabilized cubic zirconia) and matrices for 129I immobilization based on copper iodide and metallic copper were obtained. The leaching rate from these samples of HLW elements (simulators) amounted to (0.5—1.5)·10–9 g/(cm2 ·day). Despite the high-performance characteristics of the materials obtained, some problems were revealed associated with the remote maintenance of equipment and the lack of industrial design analogues. Considering the experience gained, we believe that fairly simple equipment can be designed implying no complex systems and providing minimum preparatory operations. Joint efforts of technologists and designers will enable the automatization of equipment management and control through local control systems. Material loading and unloading operations can be robotized as well. Such technical solutions are expected to be in demand at industrial facilities for HLW final disposal (or when handling damaged fuel during the decommissioning of radiation and nuclear hazardous facilities).
Radiation resistance of organic compounds for LRW solidification
Authors:   FSUE “RADON”, Ostashkina E. E. , Savkin A. E. ,   FSUE “RADON”
Published: December 2021

Experiments were carried out to determine the radiation resistance of a bitumen compound produced based on genuine cubic residue from the Kalinin NPP using bitumen grades BND 60/90 and BND 90/130, polymer compounds based on spent ion exchange resins and spent inorganic sorbents. It was found that at an irradiation dose of 1·106 Gy, the volume of the bitumen compound increases to no more than 10 vol. %, which complies with the NP-019-15 requirements. The polymer compound based on spent ion-exchange resins from the testing of a pilot plant for resin conditioning directly in a disposal container by dewatering and impregnation with an epoxy binder, meets the
Underground Research Laboratory: Overcoming Uncertainties in the Assessment of Seismic Conditions for the Yeniseiskiy Site
Authors:   Federal State Budgetary Institution of Science Institute of Geosphere Dynamics of the Russian Academy of Sciences, Kishkina S. B. , Tatarinov V. N. ,   Geophysical Center of the Russian Academy of Sciences, Bugaev E. G. ,   Federal Funded Institution Scientific and Technical Center for Nuclear and Radiation Safety, Gupalo V. S. ,   Nuclear Safety Institute of the Russian Academy of Sciences, Zabrodin S. M. ,   Federal State Unitary Enterprise “National Operator for Radioactive Waste management”
Published: December 2021

The article presents the basic principles and an algorithm allowing to arrange a seismological monitoring system for the Yeniseiskiy site selected for deep geological disposal of high-level waste. It describes the seismological monitoring system developed by NO RAO in 2018 also briefly considering the seismotectonic conditions of the area. The paper describes the process that has been followed to select the corresponding sites and equipment layouts in the areas fitted with seismological monitoring stations with relevant instrumental characteristics being provided. It shows that considering the current stage of research, higher sensitivity was provided in the area as compared to the one associated with available regional seismological observations. It demonstrates the efficiency of the built-up monitoring system with its sensitivity assessment provided both based on the calculated model and under real conditions. The long-term safety assessment performed for such a facility relies upon many factors with the seismic hazard level within the area of the monitored facility also taken into consideration. To provide most reliable evaluation of seismic parameters, continuous seismological monitoring should be performed over a several years’ period along with the sensitivity assessment of the selected monitoring system. The seismological monitoring system should focus not only on the general study of the monitored territory, but also on the areas assumed as zones of most probable seismic event occurrence, i.e. areas involving tectonic faults. The relevance of this task has been repeatedly emphasized in the course of multiple discussions on this issue featuring the representatives from SC Rosatom and the Scientific and Engineering Centre for Nuclear and Radiation Safety. The monitoring system fitted within the repository area meets relevant regulatory requirements. In accordance with the existing requirements, to reduce the uncertainties in the seismic hazard assessment of the territory, the implementation of certain measures was recommended during further development of the local seismological monitoring network to identify and assess the potential of hazardous geodynamic zones.
The Radiation Situation in the Area of the Meteorit-5 Peaceful Nuclear Explosion
Authors:   State Research Center — Burnasyan Federal Medical Biophysical Center of FMBA of Russia, Titov A. V. , Shandala N. K. ,   State Research Center — Burnasyan Federal Medical Biophysical Center of FMBA of Russia, Belskikh Iu. S. ,   State Research Center — Burnasyan Federal Medical Biophysical Center of FMBA of Russia, Isaev D. V. ,   State Research Center — Burnasyan Federal Medical Biophysical Center of FMBA of Russia, Gushchina Iu. V. ,   State Research Center — Burnasyan Federal Medical Biophysical Center of FMBA of Russia, Doronieva T. A. ,   State Research Center — Burnasyan Federal Medical Biophysical Center of FMBA of Russia, Semenova M. P. ,   State Research Center — Burnasyan Federal Medical Biophysical Center of FMBA of Russia
Published: December 2021

Pursuant to relevant provision of the Federal Law No. 190-FZ On Radioactive Waste Management and Amendments to Certain Legislative Acts of the Russian Federation of July 11, 2011, radioactive waste generated due to the peaceful uses of nuclear charges has been attributed to the non-retrievable radioactive waste (RW) category. Accordingly, relevant RW subsoil areas are currently considered as facilities holding non-retrievable RW with periodic radiation monitoring that should be performed and certain measures provided to ensure the long-term safety of the population. The article presents the results of a radiation survey performed in 2019 for the site with non-retrievable RW inventory generated from the Meteorite-5 peaceful nuclear explosion.
Pemetaan Resiko Teknologi Informasi dengan Integrasi IT Balanced Scorecard dan NIST SP 800-34 Rev.1
Authors: Prabowo Wahyu Adi , Saputri Marheni Eka
Published: December 2021

Resiko Teknologi Informasi (TI) di lingkungan pendidikan tinggi merupakan suatu kejadian yang potensial untuk mengganggu berjalannya proses bisnis. Masih banyak resiko-resiko TI yang belum terpetakan sehingga masih ada ketidakseimbangan dalam proses identifikasi resiko yang menyebabkan tidak tercapainya tujuan visi misi pada Unit TI pendidikan tinggi. Untuk mengatasi ketidakseimbangan tersebut maka diperlukan untuk mengidentifikasi resiko TI untuk meningkatkan layanan TI agar tidak terhentinya proses bisnis pendidikan tinggi. Tujuan dari penelitian ini adalah untuk melakukan pemetaan yang terintegrasi antara tujuan dan risk, yaitu dengan menggunakan IT Balanced Scorecard dan NIST SP 800-34 Rev.1. Metode dari penelitian ini adalah dengan mengumpulkan beberapa data informasi terkait IT Balanced Scorecard dan NIST SP 800-34 Rev.1 lalu dianalisa untuk membuat sebuah perencanaan resiko Teknologi Informasi. Hasil dari penelitian ini dapat memberikan gambaran bahwa resiko dapat dipetakan ke dalam sasaran strategis yang ada dalam IT Balanced Scorecard, sehingga dapat menyeimbangkan antara kinerja dan resikonya agar dapat tercapainya visi misi Unit TI pendidikan tinggi.
Otomatisasi Pembangkitan Mind Map dari Buku Teks Berbahasa Indonesia Berbasis Analisis Struktur Kalimat
Authors: Kusuma Selvia Ferdiana , Siahaan Daniel O. , Fatichah Chastine
Published: December 2021

Mind map adalah sebuah media yang dapat digunakan untuk memvisualisasikan keterkaitan suatu informasi. Adanya visualisasi informasi dapat mempermudah pemahaman terhadap informasi tersebut. Tidak ada aturan khusus dalam pembuatan mind map. Namun butuh proses yang cukup panjang ketika ingin membuat sebuah mind map, mulai dari membaca seluruh informasi, memahami keterkaitan informasi, kemudian memvisualisasikan keterkaitan informasi tersebut. Tentunya hal ini akan menyita banyak waktu. Oleh sebab itu penelitian ini mengusulkan sebuah metode otomatisasi pembangkitan mind map berbasis analisis struktur kalimat. Input dari metode ini berupa teks per bab dan outputnya adalah mind map. Setiap kalimat inputan akan diidentifikasi dan dilabeli dengan tag khusus, kemudian dari tag-tag tersebutlah akan dibentuk mind map secara otomatis dengan aturan khusus yang telah dibuat. Uji coba penelitian ini menggunakan lebih dari 1000 kalimat yang divisualisasikan menjadi sebuah mind map. Kemudian hasil visualisasi tersebut  divalidasi kebenaranya oleh ahli di bidang pendidikann yang telah memiliki pengalaman mengajar lebih dari 20 tahun. Hasil pegujian yang telah dilakukan menunjukkan bahwa metode yang diusulkan dapat digunakan untuk membangkitkan mind map secara otomatis.
Implementasi Chatbot Pembelajaran Bahasa Inggris menggunakan Media Sosial
Authors: Sarosa Moechammad , Kusumawardani Mila , Suyono Achmad , Sari Zamah
Published: December 2021

Bagi sebagian kalangan belajar bahasa Inggris adalah sesuatu yang tidak mudah sehingga perlu pendamping untuk memperbaiki jika terjadi kesalahan. Belajar bahasa Inggris bisa diawali dengan memahami secara benar strukturnya sehingga dapat membantu dan  memberikan rasa percaya ciri saat mempelajari materi-materi selanjutnya seperti reading, listening maupun writing. Penelitian ini bertujuan mengembangkan suatu aplikasi chatbot untuk belajar struktur bahasa Inggris menggunakan media sosial. Pertimbangan utama penggunaan media sosial sebagai sarana pembelajaran yaitu sebagian besar aktifitas masyarakat hingga pelajar di musim pandemic ini menggunakan media sosial atau sarana belajar berbasis online, sehingga dirasa bahwa media sosial bukan sesuatu yang baru bagi khalayak ramai dan menjadi alternatif terbaik yang dapat digunakan sebagai sarana untuk menyampaikan materi struktur bahasa Inggris. Facebook dengan fasilitas chatfuel-nya digunakan untuk mengembangkan chatbot pembelajaran struktur bahasa Inggris dengan memanfaatkan metode Organization Exercise Items (OEI). Dengan menggunakan metode OEI maka chatbot secara otomatis akan memberikan bantuan apabila ada seseorang yang sedang belajar mengalami kesulitan. Aplikasi yang diberi nama ELA-bot atau English Learning Assistant Bot ini telah diimplementasikan pada mahasiswa program studi D3 Bahasa Inggris, Politeknik Negeri Malang. Hasil pengujian menunjukkan bahwa 98% mahasiswa menyatakan chatbot telah membantu dalam proses pembelajaran struktur Bahasa inggris.
Basis Pengetahuan untuk Gangguan Perilaku Anak dengan Model Keputusan Kelompok
Authors: Rahmah Ulfatur , Tursina Tursina , Sastypratiwi Helen
Published: December 2021

Basis pengetahuan merupakan komponen yang penting dalam membangun suatu sistem cerdas terutama yang berkaitan dengan sistem yang membutuhkan kepakaran atau keahlian. Dalam penelitian ini, dibangun sebuah basis pengetahuan dengan model keputusan kelompok, yaitu keputusan yang diambil dari beberapa pakar yang berkaitan dengan gangguan perilaku pada anak. Pakar dalam hal ini berperan sebagai pengambil keputusan dalam memberikan preferensi terhadap gejala yang sudah dikumpulkan. Preferensi yang diberikan oleh pakar yaitu menggunakan format vektor utilitas, format ini memiliki kemiripan dengan konsep fuzzy dimana nilai preferensi yang diberikan yaitu dengan rentang 0 sampai 1. Hasil dari vektor utilitas tersebut kemudian ditransformasikan menjadi relasi preferensi fuzzy dalam bentuk matrik. Matrik preferensi fuzzy yang telah dibentuk diagregasikan dengan operator Ordered Weighted Averaging (OWA) dan dilakukan perangkingan dengan operator Quantifier Guided Dominance Degree (QGDD)  untuk mendapatkan  nilai bobot rule yang terbentuk atau nilai kinerja. Pada penelitian ini terkumpul sebanyak 20 gejala dengan 5 gangguan perilaku pada anak. Berdasarkan pengujian kevalidan data dengan menggunakan member check dan juga triangulasi . Basis pengetahuan dengan mengimplementasikan model keputusan kelompok ini menghasilkan sebanyak 19 pengetahuan dalam bentuk IF-THEN dengan bobot yang berbeda.
Antibody Therapy: Past, Present and Future
Authors:   Centre for Bio separation Technology, Vellore Institute of Technology, Vellore, India, D Moitra , A Miraclin Prasanna ,   Centre for Bio separation Technology, Vellore Institute of Technology, Vellore, India, N Gul ,   Govt College for Women, Srinagar, India, P Sen ,   Centre for Bio separation Technology, Vellore Institute of Technology, Vellore, India
Published: December 2021

The emergence of pandemics like SARS-CoV-2 and a gradual increase in Multidrug Resistant (MDR) infections highlights the need of innovation in therapeutics. Antibodies are one of the potential solutions for long. Antibody therapy has come very long way from the fight against infectious diseases, bacterial toxins to hybridoma technology and monoclonal antibodies. Hybridoma cells receive a deserving attention due to their antigen-specificity. But, as they were murine in origin, Human Anti Murine Antibody (HAMA) emerged. To achieve this, phage display was introduced. The emergence of molecular cloning lead to the generation of genetically engineered recombinant antibodies such as Fab, Fc, Variable Fragment (Fv), Single Chain Variable Fragments (scFv), single domain antibodies, diabodies; like scFv fragments to different moieties, such as drugs toxins, radionuclides, liposomes or quantum dots etc. Minimized antibodies have several advantages like rapid blood clearance, reduced immunogenicity, low retention time in non-target tissues, access to cryptic epitopes facilitating tumor penetration, rapid growth facilitating higher yield and lower production cost. This paper gives an overview of the history of development of antibodies and its fragments as potential therapeutic agents for the treatment of infectious diseases, one of the biggest challenges of humanity.
Development of a NanoBRET assay to validate dual inhibitors of Sirt2-mediated lysine deacetylation and defatty-acylation that block prostate cancer cell migration
Authors: Vogelmann Anja , Schiedel Matthias , Wössner Nathalie , Merz Annika , Herp Daniel , Hammelmann Sören , Colcerasa Arianna , Komaniecki Garrison , Hong Jun Young , Sum Manuela , Metzger Eric , Neuwirt Emilia , Zhang Lin , Einsle Oliver , Groß Olaf , Schüle Roland , Lin Hening , Sippl Wolfgang , Jung Manfred
Published: December 2021

Sirtuin2 (Sirt2) with its NAD+-dependent deacetylase and defatty-acylase activities plays a central role in the regulation of specific cellular functions. Dysregulation of Sirt2 activity has been associated with the pathogenesis of many diseases, thus making Sirt2 a promising target for pharmaceutical intervention. Herein, we present new high affinity Sirt2 selective Sirtuin-Rearranging Ligands (SirReals) that inhibit both Sirt2-dependent deacetylation and defatty-acylation in vitro and in cells. We show that dual inhibition of Sirt2 results in strongly reduced levels of the oncogene c-Myc and an inhibition of cancer cell migration. Furthermore, we describe the development of a NanoBRET-based assay for Sirt2, thereby providing a method to study cellular target engagement for Sirt2 in a straightforward and accurately quantifiable manner. Applying this assay, we could confirm cellular Sirt2 binding of our new Sirt2 inhibitors and correlate their anticancer effects with their cellular target engagement.
Frequency-selective Heteronuclear Correlation (FS-HETCOR) Experiments in Solid-State NMR
Authors: Zhang Zhengfeng , Su Yongchao , Yang Jun
Published: December 2021

Heteronuclear correlation (HETCOR) is critical to obtain structural information in solid-state nuclear magnetic resonance (NMR). We propose novel frequency-selective Heteronuclear correlation (FS-HETCOR) experiments to selectively enhance the inter-atomic correlations of interest. FS-HETCOR relies on heteronuclear selective phase-optimized recoupling (SPRx), which is frequency-selective in heteronuclear recouping without using selective pulses. Compared to regular HETCOR, FS-HETCOR selectively enhances the desired heteronuclear correlations by a factor of up to 5 and suppresses the unwanted ones to 10% as demonstrated in 1H-19F and 1H-13C experiments under fast magic-angle spinning (MAS). Moreover, FS-HETCOR can theoretically be applied at arbitrary MAS rates by utilizing various SPRx schemes. We believe that the method will enhance the ability of solid-state NMR to probe heteronuclear structural information.
Reversible microscale assembly of nanoparticles driven by the phase transition of a thermotropic liquid crystal
Authors: Fhionnlaoich Niamh Mac , Schrettl Stephen , Tito Nicholas B. , Yang Ye , Nair Malavika , Serrano Luis A. , Harkness Kellen , Silva Paulo Jacob , Frauenrath Holger , Carter W Craig , Stellacci Francesco , Guldin Stefan
Published: December 2021

The arrangement of nanoscale building blocks into patterns with microscale periodicity is challenging to achieve via self-assembly processes. Here, we report on the phase transition-driven collective assembly of gold nanoparticles in a thermotropic liquid crystal. A temperature-induced transition from the isotropic to the nematic phase leads to the assembly of individual nanometre-sized particles into arrays of micrometre-sized aggregates, whose size and characteristic spacing can be tuned by varying the cooling rate. This fully reversible process offers hierarchical control over structural order on the molecular, nanoscopic, and microscopic level and is an interesting model system for the programmable patterning of nanocomposites with access to micrometre-sized periodicities.
Ultrafast Triplet Generation at the Lead Halide Perovskite/Rubrene Interface
Authors: Conti Carl , Bieber Alexander , VanOrman Zachary , Moller Gregory , Wieghold Sarah , Schaller Richard , Strouse Geoffrey , Nienhaus Lea
Published: December 2021

Triplet sensitization of rubrene by bulk lead halide perovskites has recently resulted in efficient infrared-to-visible photon upconversion via triplet-triplet annihilation. Notably, this process occurrs under solar relavant fluxes, potentially paving the way toward integration with photovoltaic devices. In order to further improve the upconversion efficiency, the fundamental photophysical pathways at the perovskite/rubrene interface must be clearly understood to maximize charge extraction. Here, we utilize ultrafast transient absorption spectroscopy to elucidate the processes underlying the triplet generation at the perovskite/rubrene interface. Based on the bleach and photoinduced absorption features of the perovskite and perovskite/rubrene devices obtained at multiple pump wavelengths and fluences, along with their resultant kinetics, our results do not support charge transfer states or long-lived trap states as the underlying mechanism. Instead, the data points towards a triplet sensitization mechanism based on rapid extraction of thermally excited carriers on the picosecond timescale.
Ligand exchange in zirconocene dichloride–diethylzinc bimetallic systems
Authors: Mozgovoj Oleg , Kadikova Rita , Parfenova Lyudmila , Khalilov Leonard , Dzhemilev Usein
Published: December 2021

The reaction between zirconocene dichloride and excess diethylzinc in d-6-benzene solution was studied. It was found that the exchange reaction between Cp2ZrCl2 and Et2Zn is accompanied by the formation of such complexes as bis-(cyclopentadienyl)ethylzirconium chloride (EtZrCp2Cl), a zirconium-organozinc complex, and bis-(cyclopentadienyl)diethylzirconium (Et2ZrCp2). It was also found that as a result of ligand exchange in zirconocene dichloride–diethylzinc bimetallic systems, the zirconium-organozinc complex is formed in minor amounts. An assessment of the thermodynamic stability of the obtained products is given based on the results of DFT analysis. The description of the NMR spectral data of the obtained organozirconium complexes is carried out.
On the Construction and Integration of a Hierarchy for the Periodic Toda Lattice with a Self-Consistent Source
Authors:   Urgench State University, Babajanov B. A. , Ruzmetov M. M. ,   Urgench State University
Published: December 2021

In this paper, it is derived a rich hierarchy for the Toda lattice with a selfconsistent source in the class of periodic functions. We discuss the complete integrability of the constructed systems that is based on the transformation to the spectral data of an associated discrete Hill‘s equation with periodic coefficients. In particular, Dubrovintype equations are derived for the time-evolution of the spectral data corresponding to the solutions of any system in the hierarchy. At the end of the paper, we illustrate our theory on concrete example with analytical and numerical results.