bluuebunny/crossref_metadata_2025 huggingface dataset:
Small Molecules as Modulators of Voltage-Gated Calcium Channels in Neurological Disorders: State of the Art and Perspectives
Authors: Lanzetti Stefano , Di Biase Valentina
Published: February 2022

Voltage-gated calcium channels (VGCCs) are widely expressed in the brain, heart and vessels, smooth and skeletal muscle, as well as in endocrine cells. VGCCs mediate gene transcription, synaptic and neuronal structural plasticity, muscle contraction, the release of hormones and neurotransmitters, and membrane excitability. Therefore, it is not surprising that VGCC dysfunction results in severe pathologies, such as cardiovascular conditions, neurological and psychiatric disorders, altered glycemic levels, and abnormal smooth muscle tone. The latest research findings and clinical evidence increasingly show the critical role played by VGCCs in autism spectrum disorders, Parkinson’s disease, drug addiction, pain, and epilepsy. These findings outline the importance of developing selective calcium channel inhibitors and modulators to treat such prevailing conditions of the central nervous system. Several small molecules inhibiting calcium channels are currently used in clinical practice to successfully treat pain and cardiovascular conditions. However, the limited palette of molecules available and the emerging extent of VGCC pathophysiology require the development of additional drugs targeting these channels. Here, we provide an overview of the role of calcium channels in neurological disorders and discuss possible strategies to generate novel therapeutics.
Simultaneous Quantification of Organic Acids in Tamarillo (Solanum betaceum) and Untargeted Chemotyping Using Methyl Chloroformate Derivatisation and GC-MS
Authors: Pook Chris , Diep Tung Thanh , Yoo Michelle Ji Yeon
Published: February 2022

Sixteen organic acids were quantified in peel and pulp of Amber, Laird’s Large and Mulligan cultivars of tamarillo using GC-MS. Fourteen of these compounds had not previously been quantified in tamarillo. An untargeted metabolomics approach was used in parallel to identify and quantify 64 more metabolites relative to the internal standard, indicating abundances of glutamic acid, pro-line, aspartic acid and γ-aminobutyric acid as well as lower concentrations of several other essential fatty acids and amino acids. The main findings were that total organic acid concentration was significantly higher (p < 0.05) in pulp than in peel, with the highest concentration seen in Mulligan pulp (219.7 mg/g DW). Remarkably, after citric acid, the potent bactericide itaconic acid was the second most abundant organic acid. At least 95% of organic acids in tamarillo were one of these two acids, as well as cis-aconitic, malic and 4-toluic acids. Differences between cultivar chemotypes were as substantial as differences between tissues. These results suggest that the bitter flavour of the peel does not result from organic acids. The combination of targeted and untargeted metabolomics techniques for simultaneous qualitative and quantitative investigation of nutrients and flavours is efficient and informative.
The Role of Flavonoids as a Cardioprotective Strategy against Doxorubicin-Induced Cardiotoxicity: A Review
Authors: Syahputra Rony Abdi , Harahap Urip , Dalimunthe Aminah , Nasution M. Pandapotan , Satria Denny
Published: February 2022

Doxorubicin is a widely used and promising anticancer drug; however, a severe dose-dependent cardiotoxicity hampers its therapeutic value. Doxorubicin may cause acute and chronic issues, depending on the duration of toxicity. In clinical practice, the accumulative toxic dose is up to 400 mg/m2 and increasing the dose will increase the probability of cardiac toxicity. Several molecular mechanisms underlying the pathogenesis of doxorubicin cardiotoxicity have been proposed, including oxidative stress, topoisomerase beta II inhibition, mitochondrial dysfunction, Ca2+ homeostasis dysregulation, intracellular iron accumulation, ensuing cell death (apoptosis and necrosis), autophagy, and myofibrillar disarray and loss. Natural products including flavonoids have been widely studied both in cell, animal, and human models which proves that flavonoids alleviate cardiac toxicity caused by doxorubicin. This review comprehensively summarizes cardioprotective activity flavonoids including quercetin, luteolin, rutin, apigenin, naringenin, and hesperidin against doxorubicin, both in in vitro and in vivo models.
Lipid-Based Formulations Containing Labrafil M2125-CS: A Deep Investigation on Nanosystem Stability
Authors: Tarsitano Martine , Cristiano Maria Chiara , Mancuso Antonia , Barone Antonella , Torella Daniele , Paolino Donatella
Published: February 2022

Labrafil M2125-CS is a non-ionic surfactant component widely used for improving the solubilization of poor water-soluble drugs and as component of lipid-based nanosystem formulation. The aim of this research work was to evaluate in depth the stability of lipid-based nanosystems when exposed at several experimental conditions, such as temperature- and pH-variations, and during a specific storage process—lyophilization. Dynamic light scattering was the main analysis carried out during this research work for investigating eventual physico-chemical variations of nanosystem properties after different storage phases. We demonstrated that many of prepared formulations were able to maintain almost unchanged mean size and polydispersity index values, resisting acid and basic pH or high and low temperature, as well as the freeze-drying process. Finally, the results showed that there are no univocal experimental conditions suitable for the storage of all formulation types, but each sample requires customized conditions.
Nanocellulose in Heterogeneous Water-Based Polymerization for Wood Adhesives
Authors: Fritz Consuelo , Olivera Juan Francisco
Published: February 2022

The interest in the development of biobased adhesives has increased due to environmental concerns. Moreover, as the production of engineered wood products (EWPs) is expected to grow, the wood adhesives market needs to transit toward formaldehyde-free products. Cellulose nanoparticles (CNPs) are a material with unique properties and advantages for producing hybrid materials as biobased wood adhesives. Besides their traditional use as reinforcing additives, CNPs can be incorporated at the beginning of the polymerization reaction to form in situ polymerized hybrid adhesives with better mechanical and physicochemical properties than the neat adhesive. Despite their outstanding characteristics, CNPs are still an emerging nanomaterial in the wood adhesive field, and the studies are incipient. This review explores the utilization of CNPs in heterogeneous polymerization for the production of polyvinyl acetate, polymeric isocyanates, waterborne polyurethane systems, and other waterborne polymer latexes. The main challenges are discussed, and some recommendations are set down for the manufacture of these novel hybrid nanocomposites.
Omics in Radiation Biology: Surprised but Not Disappointed
Authors: Subedi Prabal , Moertl Simone , Azimzadeh Omid
Published: February 2022

High-throughput omics platforms have pioneered our approach to understanding biological and cellular processes. Omics technologies provide powerful tools for studying various molecules, such as genes, proteins, and metabolites, in a particular state and at a particular time. Although omics has had a presence in the radiation community for more than 3 decades, the use of it is still in its infancy. Omics studies enable radiation researchers to understand the molecular mechanism underlying the biological effects of radiation exposure on normal and cancerous tissues, and to answer critical questions such as individual sensitivity, risk assessment, and biomarker discovery. In this commentary, we take a look back at the omics studies that have been conducted in radiation research in the last 20 years and discuss whether omics has fulfilled expectations by examining the knowledge and research gaps in radiation omics.
Introducing a Novel Biorelevant In Vitro Dissolution Method for the Assessment of Nicotine Release from Oral Tobacco-Derived Nicotine (OTDN) and Snus Products
Authors: Knopp Matthias M. , Kiil-Nielsen Nikolai K. , Masser Anna E. , Staaf Mikael
Published: February 2022

The rate at which oral tobacco-derived nicotine (OTDN) and snus pouches release nicotine into saliva is crucial to determine product performance. As no standardized method is available for this purpose, this study sought to develop a biorelevant dissolution method that could both discriminate between different products and predict in vivo behavior. Using a μDISS Profiler™ as a surrogate for the US Pharmacopoeia standard apparatuses and a custom-made sinker, nicotine release from an OTDN pouch product (ZYN® Dry Smooth) and a snus product (General® Pouched Snus White Portion Large) was determined in biorelevant volumes (10 mL) of artificial saliva. In addition, nicotine extraction in vivo was measured for both products. Strikingly, the method showed distinct dissolution curves for OTDN and snus pouches, and the nicotine release observed in vitro did not significantly differ from the nicotine extracted in vivo. The custom-made sinker was designed to accommodate both loose and pouched oral tobacco/nicotine products, and thus the proposed in vitro dissolution method is suitable to assess nicotine release from OTDN and snus pouches. Apart from providing individual dissolution curves, the method was also able to predict in vivo nicotine extraction. Thus, this method could serve as a (biorelevant) monograph for product equivalence studies.
Factors Associated with Treatment Outcome in Patients with Nontuberculous Mycobacterial Pulmonary Disease: A Large Population-Based Retrospective Cohort Study in Shanghai
Authors: Cheng Li-Ping , Chen Shan-Hao , Lou Hai , Gui Xu-Wei , Shen Xiao-Na , Cao Jie , Sha Wei , Sun Qin
Published: February 2022

Infectious diseases caused by nontuberculous mycobacteria (NTM) are increasingly common. This retrospective cohort study examined factors associated with outcomes in patients from Shanghai who had NTM pulmonary disease (NTMPD) from January 2014 to December 2018. The causative bacterial species, drug susceptibility test results, treatment outcomes, sputum culture conversion rate, and risk factors associated with treatment failure were determined. The most common species were Mycobacterium avium complex (MAC) (50%), M. abscessus (28%), and M. kansasii (15%). Over five years, the proportions of M. kansasii and M. abscessus increased, and that of MAC decreased. The treatment success rate was significantly greater for patients infected with M. kansasii (89.9%) than MAC (65.0%, p < 0.001) and M. abscessus (36.1%, p < 0.001). Multivariate analysis indicated the risk factors for treatment failure were pathogenic NTM species (M. abscessus: aOR = 9.355, p < 0.001; MAC: aOR = 2.970, p < 0.001), elevated ESR (>60 mm/h: aOR = 2.658, p < 0.001), receipt of retreatment (aOR = 2.074, p < 0.001), and being middle-aged or elderly (>60 years-old: aOR = 1.739, p = 0.021; 45–60 years-old: aOR = 1.661, p = 0.034). The main bacterial species responsible for NTMPD were MAC, M. abscessus, and M. kansasii. Patients who were infected by M. abscessus or MAC, with elevated ESR, received retreatment, and were middle-aged or elderly had an increased risk of treatment failure.
The impact of the novel coronavirus infection on human mental health
Authors:   Saratov State Medical University named after V. I. Razumovsky of the Ministry of Health of the Russian Federation, Saratov, Samoilova Daria Dmitrievna Samoilova Daria Dmitrievna , Boroday Alexandra Aleksandrovna Boroday Alexandra Aleksandrovna ,   Saratov State Medical University named after V. I. Razumovsky of the Ministry of Health of Russia, Saratov, Tyapkina Daria Andreevna Tyapkina Daria Andreevna ,   Saratov State Medical University named after V. I. Razumovsky of the Ministry of Health of Russia, Saratov
Published: February 2022

To assess the impact of the novel coronavirus infection on the mental health of the population, a search was performed in the PubMed electronic database, as well as in scientific electronic libraries, such as eLIBRARY.RU and «CyberLeninka». The mental manifestations of anxiety disorders include: irritability, impatience, a feeling of tension, inability to relax, inability to concentrate, memory impairment, fatigue, fears, obsessive thoughts, insecurity and anxiety. The increased level of anxiety may be the result of misinformation transmitted through social networks. People who follow the news about COVID-19 the most experience more anxiety. Health workers are at the greatest risk of negative psychological impact during pandemics, especially if they have direct contact with the infected. The most pronounced symptoms were observed in middle and junior medical staff, women and young people working in the «red zone». During the pandemic, the levels of anxiety, depression and stress are significantly higher in the age group of 21–40 years. Women are at a higher risk of depression. During the COVID-19 pandemic, people with higher levels of education had higher levels of anxiety, depression and stress. People who have had a history of health problems, as well as those who suffer from poor health, may feel more vulnerable to the new disease. Most adolescents reacted to the stressful situation with suicidal forms of behavior — auto-aggressive and autistic-depressive. Thus, the COVID-19 pandemic can affect the mental health of individuals, various communities and social groups. Therefore, in the current crisis, it is vital to identify people who are prone to psychological disorders in order to preserve and improve the mental health of the population as a whole with the help of appropriate psychological strategies, methods and interventions.
Features of bipolar depression in the postpartum period: a clinical case
Authors:   FSAEI HE I.M. Sechenov First Moscow State Medical University (Sechenov University), Kinkulkina Marina Arkadievna , Tikhonova Yuliya Gulyamovna Tikhonova Yuliya Gulyamovna ,   FSAEI HE I.M. Sechenov First Moscow State Medical University (Sechenov University), Avdeeva Tatyana Ivanovna ,   FSAEI HE I.M. Sechenov First Moscow State Medical University (Sechenov University), Makarova Mariya Aleksandrovna ,   FSAEI HE I. M. Sechenov First Moscow State Medical University (Sechenov University)
Published: February 2022

The postpartum period is quite often complicated by the occurrence of mental disorders of various origins. One of the most common complications is postpartum depression (PPD). At the same time, the presence of a history of endogenous mental illness in women significantly increases the risk of developing postpartum depression. The closest relationship is found between PPD and bipolar affective disorder (BAD). According to the literature, postpartum depression in the context of bipolar disorder almost always proceeds in a milder form with a predominance of atypical and anxiety symptoms. The paper presents an analysis of a clinical case of severe postpartum depression in a patient with bipolar affective disorder.
Cognitive disorders associated with social frustration in elderly citizens of the Republic of Karelia
Authors:   Medical institute, Petrozavodsk state university, Hyanikyaynen Igor Viktorovich , Dmitryakova Anna Anatoljevna ,   Medical institute of Petrozavodsk State University, Burkin Mark Mihaylovich ,   Medical institute, Petrozavodsk state university
Published: February 2022

The aim is to analyze the relationship between the subjective assessment of their cognitive status by elderly citizens of the Republic of Karelia and the indicators of their social frustration. Methods. The level of social frustration according to L.I. Wasserman’s test, subjective assessment of cognitive impairments according to the self-diagnosis questionnaire of cognitive disorder by McNer and Kahn in 411 elderly people living in Petrozavodsk, Republic of Karelia was studied. The average age of the respondents was 64,43 ± 6,57 years; men made up 32,6 % (n = 134), women — 67,4 % (n = 277). Results. It was revealed that elderly citizens were characterized by a low final average index of social frustration — 1,68 ± 1,22 points, but at the same time they were completely dissatisfied with their financial situation (30,90 %), the situation in society (state) (30,41 %), medical services (23,36 %), the sphere of services (20,68 % of respondents). In the repertoire of frustrations, a significant (p = 0,0094) gender specificity was traced only in the position of «marital relations» with the prevalence of concern among men. Among elderly residents of Petrozavodsk, clinically pronounced cognitive impairments are observed in 7,46 % of women and 9,34 % of men. Their leading complaints in the cognitive sphere are: obsessive doubts (8,27 %), forgetting phone numbers (5,84 %), using memoranda (3,89 %), slowness (3,89 %). At the same time, men significantly more often forget the day of the week (р = 0,05), and women mostly experience obsessive doubts (р = 0,00), are characterized by indecision (р = 0,05) and note a feeling of «emptiness» in their heads (р = 0,04). Moreover, the severity of frustration is directly proportional to the subjective assessment by persons of the «third age» of the score of their cognitive incapacity. Conclusions. The above-mentioned mal-adaptive frustrating installations of the elderly townspeople of the Republic of Karelia lead to a deterioration in their cognitive functions, which must be taken into account when optimizing strategies for the provision of medical and social assistance on a population scale.
THE ARCTIC — NATURAL RESOURCE MANAGEMENT: A TEST ON MATURITY
Authors: Andreeva Elena N.
Published: February 2022

The article examines the present-day situation in management of the most important field for the country — natural resource and mineral management — which has undergone significant changes in the post-Soviet period. The reforms have touched both the federal authorities responsible for the development of plans for analyzing future industrial demands on domestic and international markets and their supply with mineral resources, and the state-run organizations responsible for replenishing and maintaining the country’s raw materials database. The main focus of this article is on the lack of extraction on the RF territory of the kinds of minerals which have been at the epicenter of the international market due to the appearance of new industrial and technological innovations and breakthroughs, which have lately become the determining factor of the level of economic development of a country. In Russia, these minerals are completely ignored even though the Northern, Arctic and Far-Eastern regions feature a nearly inexhaustible supply of these raw materials. Remaining in the shadow of great success in extracting hydrocarbons and of their demand on the Western and Asian markets, not only do the problems with managing the use of polymetals and rare earth metals in Russia not receive proper attention, but this management can fall under the sole purview of foreign companies altogether. The article analyzes the extremely unsatisfactory performance of federal authorities responsible for the planning of future use of natural resources and minerals as they do not maintain a close relationship with and do not follow the recommendations of the leading geological institutes of the country. These authorities are moving further and further away from providing the national economy with strategic raw materials, fail to effectively manage federal financial resources allocated for the replenishment of the national natural resource inventory, shifting the responsibility onto large private extractive companies whose primary concern has always been to fulfill their own commercial needs first. The article especially focuses on the Arctic zone of the RF, the least explored and the richest area in terms of natural resources, which can, if properly managed, make Russian economy self-sufficient, despite the growing sanctions against it, while supplying the international market with the most valuable resources. The current natural resource and mineral management, run by unprofessional staff at the most senior levels, completely contradicts the ideology of a sustainable development of the Russian society, the ideology which alone can bring the country to a new, progressive level. This article shows the acute need for an increased federal involvement in managing strategic types of mineral resources and the need to keep them from becoming foreign company assets.
Shared decision making between older people with multimorbidity and GPs: a qualitative study
Authors: Brown Emily L , Poltawski Leon , Pitchforth Emma , Richards Suzanne H , Campbell John L , Butterworth Joanne E
Published: February 2022

Background

Shared decision making (SDM), utilising the expertise of both patient and clinician, is a key feature of good-quality patient care. Multimorbidity can complicate SDM, yet few studies have explored this dynamic for older patients with multimorbidity in general practice.

Aim

To explore factors influencing SDM from the perspectives of older patients with multimorbidity and GPs, to inform improvements in personalised care.

Design and setting

Qualitative study. General practices (rural and urban) in Devon, England.

Method

Four focus groups: two with patients (aged ≥65 years with multimorbidity) and two with GPs. Data were coded inductively by applying thematic analysis.

Results

Patient acknowledgement of clinician medicolegal vulnerability in the context of multimorbidity, and their recognition of this as a barrier to SDM, is a new finding. Medicolegal vulnerability was a unifying theme for other reported barriers to SDM. These included expectations for GPs to follow clinical guidelines, challenges encountered in applying guidelines and in communicating clinical uncertainty, and limited clinician self-efficacy for SDM. Increasing consultation duration and improving continuity were viewed as facilitators.

Conclusion

Clinician perceptions of medicolegal vulnerability are recognised by both patients and GPs as a barrier to SDM and should be addressed to optimise delivery of personalised care. Greater awareness of multimorbidity guidelines is needed. Educating clinicians in the communication of uncertainty should be a core component of SDM training. The incorrect perception that most clinicians already effectively facilitate SDM should be addressed to improve the uptake of personalised care interventions.
Understanding Contact Electrification at Water/Polymer Interface
Authors: Nan Yang , Shao Jiajia , Willatzen Morten , Wang Zhong Lin
Published: February 2022

Contact electrification (CE) involves a complex interplay of physical interactions in realistic material systems. For this reason, scientific consensus on the qualitative and quantitative importance of different physical mechanisms on CE remains a formidable task. The CE mechanism at a water/polymer interface is a crucial challenge owing to the poor understanding of charge transfer at the atomic level. First-principle density functional theory (DFT), used in the present work, proposes a new paradigm to address CE. Our results indicate that CE follows the same trend as the gap between the highest occupied and lowest unoccupied molecular orbitals (HOMO and LUMO) of polymers. Electron transfer occurs at the outmost atomic layer of the water/polymer interface and is closely linked to the functional groups and atom locations. When the polymer chains are parallel to the water layer, most electrons are transferred; conversely, if they are perpendicular to each other, the transfer of charges can be ignored. We demonstrate that a decrease in the interface distance between water and the polymer chains leads to CE in quantitative agreement with the electron cloud overlap model. We finally use DFT calculations to predict the properties of CE materials and their potential for triboelectric nanogenerator energy harvesting devices.
Reformulasi Strategi Pemasaran Bengkel Otomotif Mengunakan Metode SWOT Dan QSPM
Authors: Abdillah Achmad Maulana , Mahbubah Nina Aini , Rizky Akhmad Wasiur
Published: February 2022

The rised in number  of four-wheeled vehicles in Indonesia has a positive impact on elevating business opportunities for otomotive repair services. This type of business is reside in all over region with service level vary from conventional services to advance services. Hari Jaya Teknik is a medium-sized service enterprise which focus on otomotive repairements in Gresik city. The business is experiencing with decreasing customers’ demand caused by conventional business promotion techniques and a number of  business competition around bussiness location. This study aims to reformulate a marketing strategy to maintain the existence of a business that has been built for more than twenty years. SWOT and QSPM are the approaches used in this study. The research method begins by identifying internal and external factors obtained from six expert respondents, followed by the calculation of the SWOT and QSPM matrix. The results of this study found eight factors as primary consideration in order to redevelop marketing strategy. The highest factor namely strategy to both maintain and enhance the quality of service. These factors followed by calculating reasonable service costs in order to maintainbussiness  reputation as well as customer loyalty. The reformulation of the eight strategies is also expected to be able to bring in new customers in the workshop in order to sustaining bussiness existence.
Обґрунтування технічних пропозицій щодо спряження сучасних ПЕОМ зі спеціалізованими обчислювальними засобами зенітного ракетного озброєння з метою модернізації та підвищення
Authors: Бортновський Сергій Анатолійович , Звєрєв Олексій Олексійович , Животовський Руслан Миколайович , Петрук Сергій Миколайович , Рамшов Денис Володимирович
Published: February 2022

У статті надані результати рішення важливого та актуального науково-технічного завдання теорії і практики зенітних ракетних військ щодо можливості впровадження та застосування сучасних персональних електронно-обчислювальних машин у складі спеціалізованих управляючих цифрових обчислювальних засобів комплексів засобів автоматизації існуючих типів командних пунктів зенітних ракетних систем і комплексів Повітряних сил Збройних Сил України. Обґрунтовані принципи спряження та розроблені універсальні технічні засоби узгодження інформаційного обміну сучасних персональних електронно-обчислювальних машин із штатним типовим інтерфейсом “ЗАГАЛЬНА ШИНА” зі складу управляючих цифрових обчислювальних засобів і апаратурних трактів обміну цифровою інформацією комплексів засобів автоматизації командних пунктів зенітних ракетних систем (комплексів).
The Relationship Between Extracellular Matrix Proteins and Germ Cell Apoptosis in Balb/C Mouse Testis Following Experimental Hypothyroidism
Authors: Alipour Fatemeh , Jalali Mehdi , Nikravesh Mohammad Reza , Fazel Alireza , Sankian Mojtaba , Khordad Elnaz
Published: February 2022

Objectives: Dysfunction of the thyroid gland has a negative effect on the male reproductive system. Studies also show that extracellular matrix (ECM) components play an essential role in testicular development and function. In hypothyroidism, there is a significant disruption in the ECM structure of mammalian tissues. In addition, notable changes have been reported in the germ cell population under a hypothyroid state. This study aimed to investigate the relationship between ECM proteins and apoptosis of testicular germ cells due to hypothyroidism. Materials and Methods: In the present experimental study, 20 male Balb/C mice were divided into control and hypothyroid groups. The hypothyroid group received 0.05% 6-n-propyl-2-thiouracil (PTU) through drinking water for 35 days. Finally, real-time polymerase chain reaction, immunohistochemistry, periodic acid-Schiff (PAS) staining, terminal transferase-mediated dUTP nick-end labelling (TUNEL) assay, and biochemical measurements were performed after hypothyroidism confirmation. Results: Laminin α5 and collagen IV mRNA levels were upregulated in the hypothyroid group compared to the controls (P<0.05). Further, a strong immunoreactivity of collagen IV and laminin α5 was observed in the basement membrane (BM) of hypothyroid mice (P<0.05). In contrast, there was no significant difference between the case and control groups regarding PAS staining. The number of TUNEL-positive germ cells in hypothyroid mice increased significantly compared to control mice. Moreover, PTU administration reduced superoxide dismutase activity while increasing the malondialdehyde level (P<0.05). Eventually, no significant difference was found between the two groups in terms of thiol content. Conclusions: Based on the results of the present study, hypothyroidism can cause changes in BM components and increase the apoptosis of germ cells by inducing lipid peroxidation and reducing the activity of antioxidant defense molecules.
Reproductive and Menstrual Risk Factors for Endometriosis Disease: A Case-Control Study
Authors: Mollazadeh Sanaz , Kamalifard Mahin , Sadeghzadeh Oskouei Behnaz , Aminisani Nayyereh , Jafari Shobeiri Mehri , Mirghafourvand Mojgan
Published: February 2022

Objectives: The endometriosis prevalence in the general population is about 7%-10%. In 30% of women, endometriosis is one of the causes of primary and secondary infertility. There are various risk factors for this disease. The present study aimed to determine the reproductive and menstrual risk factors of endometriosis. Materials and Methods: In this case-control study, 185 women of reproductive age with confirmed endometriosis were compared with 370 women of reproductive age who referred to the same center for other problems in terms of reproductive and menstruation risk factors for endometriosis. The two groups were matched for age. Data were collected using a researcher-made questionnaire based on previous studies. Finally, bivariate analysis was done by the chi-square test, and multivariate analysis was performed by the conditional logistic regression for controlling confounder variables. Results: Based on multivariate logistic regression, early menarche age (P=0.004), no history of pregnancy (P<0.001), no child (P=0.002), no lactation history (P<0.001), high age of the first lactation (P=0.029), short duration of breastfeeding (P=0.015), no regular menstruation (P<0.001), short intervals between menstrual bleedings (P=0.016), prolonged menstruation (P<0.001), dysmenorrhea (P<0.001), dyspareunia (P<0.001), and recurrent vaginitis (P<0.001) had a significant relationship with endometriosis. Conclusions: In general, there was a relationship between some reproductive and menstrual characteristics and endometriosis. Therefore, it seems that these characteristics can predict the occurrence of endometriosis disease.
APPLICATION OF MATHEMATICAL MODELING FOR THE TRANS-PORT SYSTEM OF THE FOREST PRODUCTS WAREHOUSE
Authors: Ivannikov V , Buhtoyarov Vladimir , Golev A. , Tretyakov A.
Published: February 2022

The operation of the timber industry complex depends on the efficiency of the warehouse economy, in particular the workload of the serviced transport systems. The paper considers the issues of optimizing the operation of the warehouse of forest products by increasing the efficiency of transport work using mathematical modeling.
PROSPECTS FOR USING A FOREST TRUCK WITH REMOTE-CONTROLLED WHEEL MODULES AND A SLIDING FRAME
Authors: Nikonov Vadim , Posmetev Valeriy , Prohorov A. , Sencov D.
Published: February 2022

The necessity of improving the existing structures of timber trucks is substantiated, aimed at reducing the time of unloading timber during their delivery from the cutting area to timber processing enterprises. A promising design of a timber truck with remotely controlled wheel modules and a sliding frame is proposed. The device of such a timber truck, its operation and the main advantages achieved in the process of unloading timber are described.
Perancangan Sistem Informasi Media Promosi Pemesanan Desain Lemari dan Kamar Set Pengantin pada Toko Perabot Pinang Balirik Berbasis Web
Authors: Afif Muhammad
Published: February 2022

Pada Toko Pinang Balirik ini menyediakan perabot rumah tangga seperti lemari dan kamar set pengantin yang sangat dibutuhkan oleh masyarakat untuk melengkapi kebutuhan perabot rumah tangga. Demi menyesuaikan dengan perkembangan zaman pada saat ini maka diperlukan sistem informasi yang digunakan untuk memudahkan pelanggan dan penjual dalam menentukan desain lemari atau kamar set yang mereka butuhkan dan inginkan. Dalam hal ini, mungkin toko tersebut memerlukan sebuah sistem informasi berupa web untuk mempromosikan perabot yang mereka buat. Selain dari penjualan secara langsung dari toko, mereka juga dapat menggunakan web untuk mempermudah pekerjaan mereka agar produk yang mereka buat dapat dikenal oleh masyarakat banyak dan juga memberikan keuntungan bagi pemilik toko tersebut
género en las políticas públicas: ¿una opción o una obligación?
Authors: Levín Silvia
Published: February 2022

Durante las décadas de los noventa y del dos mil se ha afianzado en América Latina la idea de la estrecha vinculación existente entre política social, democracia y desarrollo, como resultado de estudios e investigaciones (UNESCO, 2003; PNUD, 2004; Faletto, 1993; etc.), a punto tal que hoy constituye una certeza que nos permite avanzar en sus postulados constitutivos centrales en términos sustantivos. La igualdad de género es uno de ellos.

El género hace referencia a una construcción social y cultural, que organiza nociones sobre aquello que sería “propio” de lo masculino y de lo femenino a partir de la diferencia sexual, no es natural y no afecta exclusivamente las decisiones individuales (Lamas, 1996). No se trata de una configuración identitaria individual de las personas, relacionadas con su modo de vivir la femineidad o la masculinidad, sino que influye de forma crítica en todas las relaciones sociales como la división sexual del trabajo, la distribución de recursos, el establecimiento de jerarquías, etc.
Racionalidades políticas y políticas sociales
Authors: Mrejen Matías
Published: February 2022

El presente artículo es una versión resumida de la Tesina de Grado1 para la finalización de la Licenciatura en Ciencia Política de la Universidad Nacional de Rosario.  En  ella, titulada “Racionalidades políticas y políticas sociales. Un análisis de las Transferencias Condicionadas de Ingreso en la Argentina”, se realizó un estudio sobre el surgimiento de las transferencias condicionadas de ingreso como dispositivos de gobierno en la Argentina post- crisis del 2001. De las temáticas allí tratadas, se hace hincapié en el análisis de la Asignación Universal por Hijo (AUH) como un dispositivo que articula tecnologías de gobierno de matriz welfarista –el seguro social– y de matriz neoliberal–las políticas de Transferencia Condicionada de Ingresos.
Asistencia Social y restauración neoliberal*
Authors: Campana Melisa
Published: February 2022

"Lo primero que quiero dejar claro es “desde dónde hablo”, por una cuestión de honestidad intelectual pero también de combate activo contra la pretendida neutralidad valorativa de todo orden: soy docente de la Escuela de Trabajo Social de la UNR y de la Facultad de Trabajo Social de la UNER, Investigadora del CONICET y coordinadora del Programa de Estudios Gubernamentalidad y Estado. También quiero aclarar que mi interés, no sólo hoy, en este espacio, sino en toda mi labor académica radica en explorar los usos de la herramienta teórica más que en una reflexión exegética sobre ella, en el sentido de su “significado correcto”, su “debida utilización” o su “exacta definición”. Con esto quiero decir que ahorraré lo máximo posible el preciosismo conceptual, para concentrarme en las dos o tres preocupaciones que hoy quiero compartir con ustedes..."
Problemática de la Institucionalización Crónica y el Fenómeno de «Revolving Door» en Pacientes Usuarios del Centro Regional de Salud Mental Dr. Agudo Ávila (CRSM)
Authors: Alberdi José Maria , Coll Laura , Mutazzi Eduardo , Vismara Eleonora
Published: February 2022

El objetivo fue realizar un análisis cuantitativo y cualitativo de la problemática de los pacientes de larga institucionalización (l.i.) o con repetición importante de internaciones en el CRSM. Para elaborar indicadores epidemiológicos en salud mental el estudio (analítico-descriptivo) se estableció sobre el total de pacientes de l.i. (45 pacientes, crónicos en la cultura institucional) mediante un corte longitudinal durante los meses de agosto/ septiembre de 2002. Se debe destacar que del total de la muestra 25 pacientes (55,5 %) presentan l.i. siendo que, a 20 de ellos, (44,5%) se los puede incluir en la categoría de «revolving door». El perfil construido de los pacientes arroja una tasa importante de institucionalización de pacientes con problemas de marginación socio-económica, así como un uso de la internación como forma de institucionalizar la exclusión (legal, social, familiar); se debe resaltar la institucionalización debido al déficit de otras políticas (discapacidad, tercera edad, etc.). En relación a los procesos de trabajo se observaron limitaciones en la organización del modelo asistencial debido a la hegemonía del dispositivo clínico que privilegia la atención de pacientes en crisis. Para la transformación del modelo manicomial (objeto de la ley de salud mental en vigencia) se hace necesario la promoción de servicios alternativos y sustitutivos
espejos de la infancia: retratos y autorretratos de niños/as en situación de calle
Authors: Colombo Soraya
Published: February 2022

Este trabajo surge de la investigación producida para la realización de mi tesina de grado de la Licenciatura en Trabajo Social, a partir de mi inclusión, en el mes de diciembre de 2006, en el Programa de Promoción Familiar del Área Niñez de la Municipalidad de Rosario como operadora de calle, en la zona norte de la ciudad. A partir de los registros de campo entonces elaborados (con la intención paralela de su utilización para dicha investigación) se han captado modos de ser, hacer y decir de estos niños/as que, articulados con sucesos vivenciados in situ, junto a ellos, en el ámbito mismo de la calle, fueron resignificados a partir de su relectura y agrupación en ejes de interés para el análisis y la reflexión teórica. Los mismos intentan dar cuenta de la representación de los niños/as acerca de la calle y del concepto de trabajo, de la distribución de actividades en su vida cotidiana y del lugar o no de lo lúdico/recreativo en sus actividades en calle. Se pretendió indagar así en la autorrepresentación que tienen acerca de su situación, los niños/as que realizan actividades laborales callejeras informales en la zona norte de la ciudad de Rosario, entendiendo a la autorrepresentación, tal como afirma Moscovici (1981), como la manifestación concreta de una toma de posturas sobre la identidad y la autopercepción y el modo en que ambas se conjugan para manifestarse de forma pública, para los Otros, y se ubican como detonador de un «estoy aquí». Se intentan recuperar en este proceso, las pertenencias de las que se apro- pian y las relaciones que se van construyendo en su vida cotidiana, a partir de lo que se visibiliza en el espacio de la calle.
Pobreza y modelos de intervención: aportes para la superación del modelo de asistencia y promoción
Authors: Marc Josefina , Lascialandare Natalia , Osella Pilar
Published: February 2022

El objetivo general del libro es realizar un análisis de los modelos de interven- ción sobre la pobreza en Argentina a partir de la década del ´60 hasta la actua- lidad. Arias responde a este objetivo desde una perspectiva teórica novedosa en los análisis del Trabajo Social y su historia, proponiendo una periodización y modelos en torno a las intervenciones sobre la pobreza, utilizando como dimen- siones ordenadoras de esos modelos: características socio-políticas del período, aportes desde las Ciencias Sociales, rol del Estado, idea de sujeto, definición de lo comunitario, definición de lo promocional, definición de lo asistencial, profesio- nalización de la intervención. Dimensiones necesarias para pensar continuida- des y rupturas en los diferentes modelos de intervención
Gender and Motivation among EFL Students
Authors: Firdani Firdani , Abdul Samad Nanda Marlina , Fitriani Siti Sarah , Samad Iskandar Abdul , Ananda Rizki
Published: February 2022

Motivation is an important factor for explaining the success or failure of any complex task. Motivation is related to gender which plays an important role in one’s life. This study focuses on finding out the correlation between gender and motivation among students in learning English as a foreign language. It looks particularly on determining how motivation in learning English as a foreign language is influenced by gender. The researchers employed qualitative research where the data were obtained by questionnaire. Ten participants of this research were chosen for this research. They are five males and five female postgraduate students of English Education Department of Syiah Kuala University. This research found that there is significant correlation between gender and motivation among EFL students in learning English in which female students tend to be more successful and motivated than the male students regarding learning English.
L1 Use in L2: Should We Omit It? Reexamining the L2- Only Policy in Foreign Language Classroom
Authors: Maghfiroh Anisatul , Anwar Ahmad Choirul
Published: February 2022

The use of L2-only policy in foreign language classroom has been debated in academia. Questions around the debate revolve around; will it really be very effective and fruitful as well as comfortable for both the students and teachers of foreign language classes to use only L2 and completely omit L1 in their classroom activities? If not, how much should we limit the use of L1 in order to create a comprehensive language acquisition in class? The objective of this paper is to map the discussion about some supporting and opposing arguments on L2-only policy in foreign language classroom. Studies suggest that even though there are some opinions that L1 equals to comfort zone, we argue that there will not be any advantages to put the students in their anxiety when learning new language. Instead, students will feel uneasy and will result in their lack of motivation.
Students’ Perception to the Use of Indirect Corrective Feedback in Writing Recount Text
Authors: Rahma Endah Anisa , Fitriani Siti Sarah , Syafitri Rina
Published: February 2022

Providing written corrective feedback is a necessity to help language learner improve accuracy. This research aims to seek out students’ response toward the use of Indirect Corrective Feedback to reduce error on students’ recount text. Tenth graders of SMAN 1 Meulaboh were the sample of this study and observed during the correction. Data from the close-ended questionnaire was analyzed qualitatively andwere calculated using percentage system. The result showed that most students agreed about the implementation of Indirect Corrective Feedback and they believe that this error correction strategy helps them to reduce errors in writing recount text. The result confirm that the students responded positively toward the use of Indirect Corrective Feedback.
Exploring the Impact of Extroversion and Introversion Personality Types on EFL Learners’ Preferences in Publishing Research Papers
Authors: Riadil Ikrar Genidal , Nur Muhammad Rauuf Oktavian
Published: February 2022

Personality may affect our way to learn. Based on the essential role of various forms of personalities in the cycle of studying foreign languages and understanding foreign languages, this thesis seeks to explore the effect of extroversion and introversion on the identity of English as a foreign language learner in writing research articles. Fifty students are taking part in this study. Those participants are the fifth-semester students of Tidar University who take Teaching English as Foreign Language class. They have many papers from any lecture. They can produce more than three research papers in a year. Publishing their papers still become interesting topics for them. The researcher uses descriptive qualitative method to get the result. By giving a questionnaire to all of the participants to find out their personality types and then asking about their preferences in publishing research papers. Based on the findings, researcher get main result, there are more extroverts EFL Learners than the introvert one. They could give wide perspectives about publishing their papers. Their perspectives on their preferences depend on any reason that supports the result.
Analyzing EFL Learners’ Factors in Affecting English Pronunciation and The Distribution of Pronunciation Rating: A Qualitative Study
Authors: Riadil Ikrar Genidal , Yosintha Rolisda
Published: February 2022

Pronunciation is the production of speech sounds for communication. It is the most difficult area of English. Pronunciation teaching in English as a Foreign Language (EFL) curriculum has also been ignored for many factors. As a result, numerous EFL learners have often found it challenging to speak freely because of their weak pronunciation. This study deals with the Teaching English as a Foreign Language (TEFL) of speaking skill in EFL Learners of Indonesia. The researcher used qualitative research. There were thirty-five students who filled the questionnaire and ten students read text given First, the researcher looked for the questionnaire and found the questionnaire about Willingness to communicate. Second, the findings of tense were analyzed to know what factors that affect Indonesian learners’ English pronunciation. Third, the findings were shown into tables to know the factors. Then, the researcher asked ten learners to record when they read the text given (reading passage). After that, the researcher analyzed the pronunciation rating based on the trusted rating sheets. Finally, the researcher drew a conclusion based on the findings and discussion. This study is to investigate the factors affecting Indonesian students’ pronunciation and the distribution of pronunciation rating. The study seeks to answer two research questions (RQ): (RQ1) What are the factors affecting Indonesian learners’ English Pronunciation? and (RQ2) What are the distributions of Pronunciation Rating? This study adopted a descriptive qualitative approach which used questionnaire to build this research and reading passage. In conclusion, the researcher elaborated and answered the research questions, and explained the results and discussions about the type of factors that affect EFL learners’ in English pronunciation.
Development of Picture Book-Based Teaching Learning Media to Improve Student Learning Outcomes on Khulafaur Rasyidin's Material
Authors: Siti Rohemah  , Shokhibul Mighfar
Published: February 2022

The development of teaching media in the form of a picture book of Khulafaur Rashidin material aims to increase the effectiveness of student learning outcomes. The researcher used the Research and Development method to determine the effectiveness of teaching media in a picture book of Khulafaur Rasyidin's material. Researchers used two types of data, namely quantitative data and qualitative data. The validation results from the development of this picture book have valid criteria for content experts with an average score of 4.22 in the good category, media design experts with an average score of 3.7 in good category, and subject experts with an average score of 4.1 is in a good category. And in the application of learning in the field (in class) the average pre-test score is 45.7, and the post-test average is 79.1, which, if calculated using the paired sample T-test statistic, has a t-count result of 6, 53 and has a t table result of 2.160, so the total t-score results are more significant than the total t-table scores, which means H1 is accepted and H0 is rejected.