bluuebunny/crossref_metadata_2025 huggingface dataset:
Considering Peer Support Sustainability: Survey of geographic differences in roles, skills, job satisfaction, and financial well-being
Authors: Voss Maren , Barrett Tyson , Lapidos Adrienne , Werner Pam , Bennett Pamela , Campbell Amy , Komen Amelia Van
Published: October 2023

Background
The peer support workforce has become an established aspect of behavioral health care, with endorsement since 1999 as Medicaid reimbursable and with steady uptake of credentialing by 49 states and the District of Columbia. Yet sustainability issues due to wage and entry-level stagnation lacking advancement paths is a concern for the Certified Peer Support Specialists (CPSSs) workforce.
Methods
This analysis compared cross-regional survey data of employed CPPSs in Utah (U) to a prior Michigan (M) sample. The core areas of investigation were 1) health and well-being, 2) professional settings, activities, and opportunities, and 3) perceptions regarding professional practice.
Results
Over 85% of Utah peers expressed satisfaction with work hours, physical safety at work, and supportiveness of supervisors, similar to 75% Michigan sample satisfaction. Job security satisfaction differed at 87% in Utah and 67% in Michigan, with a higher average wage in Utah. Less satisfaction was reported for promotion opportunities (U-57%, M-41%) and coworker awareness of peer roles (U-34%, M-42%).
Conclusions
Results indicate similar workforce conditions across regions, but with higher pay and slightly higher satisfaction ratings in the Utah sample of mixed recovery and mental health peers. Both areas demonstrate a need for training non-peer staff on CPSS job roles, indicating a lack of clarity regarding the professional contributions of peers. Practical administrative steps to support sustainability include stigma-reducing workplace policies, trainings, career laddering with increased responsibility, sustainable wage and benefit packages consistent with career laddering, and reinforcing consensus around defined roles and competencies of peer support.
Agreement between face‑to‑face assessment and tele‑assessment of performance-based tests in older adults
Authors: Ozsoy Gulsah , AKSOY Kevser
Published: October 2023

Purpose
This study aimed to assess Timed-Up and Go (TUG), Five Times Sit-to-Stand Test (5xSST), and 4-Meter Walk Test (4MWT) intra- and inter-rater reliability between face to face and tele-assessment tools in older adults.
Methods
A total of 54 older adults (aged ≥ 65 years) were included in the study. The demographic and clinical characteristics of the participants were documented. Measurements (TUG, 5xSST, and 4MWT) were carried out face-to-face and tele-assessment. The intraclass correlation coefficients (ICCs), and Bland-Altman plots was used determine intra- and inter-rater reliability.
Results
Inter-rater reliability between face-to-face and tele-assessment was as following: excellent for TUG (ICC = 0.931) and 5STS (ICC = 0.908), and good for 4MWT (ICC = 0.803). Additionally, intra-rater reliability between the two tele-assessments was excellent for all tests. The ICC values for TUG, 5STS, and 4MWT were 0.973, 0.948, and 0.934, respectively.
Conclusion
To conclude, the TUG, 5xSST, and 4MWT seem to be reliable tools of tele-assessment in older adults. These practical assessment tools can be used in home settings for older adults as tele-health interventions.
A novel super-convergent numerical method for solving nonlinear Volterra integral equations based on B-splines
Authors: Ghasemi Mohammad , Goligerdian Arash , Moradi Sina
Published: October 2023

‎We introduce and thoroughly examine a novel approach grounded in B-spline techniques to address the solution of second-kind nonlinear Volterra integral equations‎. ‎Our method revolves around the application of B-spline interpolation‎, ‎incorporating innovative end conditions‎, ‎and delving into the associated existence and error estimation aspects‎. ‎Notably‎, ‎we develop this technique separately for even and odd-degree splines‎, ‎leading to super-convergent approximations‎, ‎particularly significant when employing even-degree splines‎. ‎This paper extends its commitment to a comprehensive analysis‎, ‎delving deeply into the method's convergence characteristics and providing insightful error bounds‎. ‎To empirically validate our approach‎, ‎we present a series of numerical experiments‎. ‎These experiments underscore the method's efficacy and practicality‎, ‎showcasing numerical approximations that closely align with the anticipated theoretical outcomes‎. ‎Our proposed method thus emerges as a promising and robust tool for addressing the challenging realm of nonlinear Volterra integral equations‎, ‎bridging the gap between theoretical expectations and practical applications‎.
2010 Mathematics Subject Classifications: 45Dxx; 65R20; 41A15.
Coupled scRNA-Seq and Bulk-seq Reveal the Role of HMMR in Hepatocellular Carcinoma
Authors: Su Zhixiong , You Lijie , He Yufang , Chen Jingbo , Zhang Guifeng , Liu Zhenhua
Published: October 2023

Background
Hyaluronan-Mediated Motility Receptor (HMMR) has been demonstrated to be overexpressed in multiple carcinomas and to influence the development and treatment of several cancers. However, its role in hepatocellular carcinoma (HCC) remains unclear.
Methods
The “limma” package in R was used to perform differential expression analysis. The “GSVA” package in R was used to assess the activity of signaling pathways, and inferCNV was used to infer copy number variation (CNV) for each hepatocyte. “CellChat” was used to analyze intercellular communication networks. Recursive partitioning analysis (RPA) was to re-stage HCC patients. The “pRRophetic” package was used to evaluate the IC50 values of some drugs. Additionally, qRT-PCR was performed to confirm HMMR expression in an HCC tissue microarray. Flow cytometry (FCM) and cloning, Edu assay, and wound healing assays were used to explore the capacity of HMMR to regulate HCC tumor.
Results
HMMR was over expressed in HCC tissue (compared to normal tissue), which was proved by multiple cohort studies and qRT-PCR. In addition, HMMR had excellent diagnostic performance. HMMR knockdown could inhibit the proliferation and migration of HCC cell lines. Moreover, high HMMR expression was associated with “G2M checkpoint” and “E2F targets” in bulk RNA and scRNA-seq, and FCM confirmed that HMMR could regulate the cell cycle. In addition, HMMR was involved in the regulation of tumor immune microenvironment via immune cell infiltration and intercellular interactions. Furthermore, HMMR was positively correlated with genomic heterogeneity and patients with high HMMR expression may benefit better from immunotherapy. Moreover, HMMR was associated with poor prognosis in HCC patients and the re-staging by RPA had a good prognosis prediction value and could guide chemotherapy and targeted therapy.
Conclusion
According to the results of the present study, HMMR could play a role in the diagnosis, prognosis and treatments of patients with HCC based on bulk RNA-seq and scRAN-seq analyses, and is a promising molecular marker for HCC.
Treatment Outcomes in Patients with Acute Thromboembolic Occlusion of the Superior Mesenteric Artery
Authors: Li Wenrui , Liu Mingyuan , Jin Lei , Feng Hai , Chen Xueming , Zhang Zhiwen
Published: October 2023

Purpose: The goals of this study were to investigate the treatment outcomes of acute thromboembolic occlusion of the superior mesenteric artery (ATOS) and identify prognostic factors after treatment.
Methods: The clinical data of 62 patients with ATOS between 2013 and 2021 were retrospectively reviewed.
Results: Sixty-two consecutive patients were identified with ATOS. The medianpatient age was 69 years (interquartile range 58–79 years). Endovascular therapy was initiated in 21 patients, and 4 patients received conservative treatment. Open surgery was performed first in the remaining 37 patients. The technical success rates of the endovascular first group and open surgery group were 90.5% and 97.3%, respectively. One patient in the conservative treatment group had progression of ischemia to extensive bowel necrosis. There was no difference in 30-day mortality between these groups. Predictors of 30-day mortality included a preoperative neutrophil count>12* 103/dL (OR 11.15, p=0.014).
Conclusions: Endovascular treatment or conservative treatment may be adopted in selected patients who do not exhibit signs and symptoms of bowel necrosis, and close monitoring for bowel necrosis is important. The increase in preoperative neutrophil count was a poor prognostic factor.
IBMESR: Towards Next-Generation Big Data Security with An Integrated Blockchain Model for Efficient, Scalable, and Robust Operations
Authors: Tota Madhavi , Karmore Swapnili
Published: October 2023

As the utilization of big data environments becomes increasingly widespread, the demand for robust and efficient security mechanisms within this context becomes paramount, especially in real-time scenarios. Ensuring data integrity, trust, and availability in multi-cloud environments is of utmost importance. Existing solutions often fall short in these aspects, resulting in issues such as latency, energy inefficiency, and vulnerability to access attacks, among other drawbacks. Traditional security models designed for big data environments tend to rely on ineffective proof mechanisms and static encryption methods. These conventional approaches lead to increased data processing delays, heightened energy consumption, and reduced communication throughput. Furthermore, these existing models have demonstrated limited capabilities in accurately identifying unauthorized access attempts, thereby escalating security risks. This paper introduces an innovative security framework tailored for big data environments, which leverages a suite of cutting-edge technologies to address the limitations of current models. The proposed architecture integrates several key components, including a Proof of Spatial & Temporal Trust-based Blockchain for secure storage operations, Grey Wolf Optimization (GWO) for efficient blockchain sharding, Fully Homomorphic Encryption (FHE) for safeguarding data across various data nodes, Physical Unclonable Functions (PuFs) for resilient inter-data node communications, and Fuzzy Rule-Based Access Control to enhance overall security. Our research results demonstrate that this proposed model significantly mitigates the inefficiencies and vulnerabilities that currently plague big data security systems. Specifically, it achieves an 8.3% reduction in data processing delays, a 4.5% reduction in energy consumption, a 2.9% improvement in communication throughput, an 8.5% enhancement in the accuracy of detecting access attacks, and a 3.5% increase in access speed levels. This innovative security framework tailored for big data environments offers a comprehensive and effective approach to overcome the limitations of existing solutions. It represents a significant advancement in the field of big data security, contributing significantly to ongoing efforts aimed at creating more secure, efficient, and resilient big data ecosystems.
Liver, Metabolic and Atherosclerotic Risks of Patients with Cryptogenic Steatotic Liver Disease
Authors: Wang Shao-Wen , Hsieh Tsung-Han , Cheng Yu-Ming , Wang Chia-Chi , Kao Jia-Horng
Published: October 2023

Background & Aims:
In 2023, a new nomenclature of "metabolic associated steatotic liver disease" (MASLD) has emerged by incorporating cardiometabolic risk factors to redefine "non-alcoholic fatty liver disease" (NAFLD). Among steatotic liver disease (SLD), a subgroup of cryptogenic SLD denotes hepatic steatosis without metabolic dysfunction. Its clinical characteristics remain unclear. .
Approach:
We analyzed participants with liver ultrasound data from the Taiwan Bio-Bank cohort, excluding those with positive HBsAg, positive anti-HCV, or “frequent drinker”. MASLD involves hepatic steatosis and any of five cardiometabolic risk factors, whereas cryptogenic SLD features hepatic steatosis without these risk factors. Liver fibrosis severity was assessed by using NAFLD fibrosis score (NFS), while atherosclerosis was determined by carotid plaques on duplex ultrasound.
Results
Among 17,595 subjects (mean age 55.59 ± 10.4; 31.8% males), 7538 participants (42.8%) had SLD, comprising 96.5% of MASLD and 3.5% of cryptogenic SLD. Cryptogenic SLD patients are younger and had a lower percentage of male than those with MASLD. After propensity score matching for age and sex, patients with cryptogenic SLD exhibited milder glucose and lipid profiles, fewer carotid plaques, lower liver steatosis, inflammation, and fibrosis markers than those with MASLD.
Conclusions
In this large population-based study, cryptogenic SLD, the excluded group, occupy only 3.5% in NAFLD patients. It has lower liver, metabolic, and atherosclerotic risks than MASLD, supporting its exclusion from NAFLD and justifying the rationale for the new disease name and diagnostic criteria of MASLD.
Carbon-Enhanced Aluminum-Based Adsorbent for Highly Efficient Removal of Fluoride Contamination from Water
Authors: Tong Lin , Miao Ying , Li Shushu , Bao Ning , Zhou Qingwen , Yang Yuhuan , Ye Changqing
Published: October 2023

Excessive fluoride presence in water poses significant environmental and public health risks, necessitating the development of effective remediation techniques. Conventional aluminum-based adsorbents face inherent limitations such as limited pH range and low adsorption capacity. To overcome these challenges, we present a facile solvent-thermal method for synthesizing a carbon-doped aluminum-based adsorbent (CDAA). Extensive characterization of CDAA reveals remarkable features including substantial carbon-containing groups, unsaturated aluminum sites, and a high point of zero charge (pHpzc). CDAA demonstrates superior efficiency and selectivity in removing fluoride contaminants, surpassing other adsorbents. It exhibits exceptional adaptability across a broad pH spectrum from 3 to 12, with a maximum adsorption capacity of 637.4 mg/g, more than 110 times higher than alumina. The applicability of the Langmuir isotherm and pseudo-second-order models effectively supports these findings. Notably, CDAA exhibits rapid kinetics, achieving near-equilibrium within just 5 minutes. Detailed analyses employing FTIR and XPS provide profound insights into the underlying mechanisms governing the adsorption process, which is facilitated by the active involvement of carbon-containing functional groups. The exceptional attributes of CDAA establish its immense potential as a transformative solution for the pressing challenge of fluoride removal from water sources.
Biological control of Alternaria alternata causing surface rot on Amasya Apples using apple endophytic bacteria
Authors: Bektas Idris , Yazdic Ferit Can , Kusek Mustafa
Published: October 2023

In this study, an isolate of Alternaria alternata, the causal agent of apple fruit rot, was isolated from rotten cv Amasya Apple and identified based on ITS gene analysis and morphological analyses. Out of 58 different endophytic bacteria isolated from internal tissues of apples, twenty-six isolates caused the radial growth inhibition of A. alternata in dual cultures. Based on 16S rRNA sequencing analysis, these endophytic antagonistic bacteria were identified as Bacillus ssp. Bacillus methylotrophicus(ib17) exhibited the highest significant inhibitory effect on the mycelial growth of A. alternata at a rate of 79.45% under in vitro conditions. The in vivo analysis revealed that the biocontrol efficiency of the Bacillus licheniformis(ib20) against A. alternata reached 100% with a treatment duration of 24 h before the introduction of A. alternata. When the bacteria and A. alternata were introduced simultaneously, Bacillus amyloliquefaciens(ib1), Bacillus licheniformis(ib21), and Endophytic bacterium (ib16) showed the highest biocontrol effect against A. alternata at 81.8%. Moreover, when the bacteria introduced 24 h after A. alternata, Bacillus licheniformis(ib21) showed the highest biocontrol efficacy at 83.3% against the fungus compared to the controls. The endophytic bacteria could produce fungus cell wall hydrolyzing enzymes such as chitinase, cellulase, amylase, and protease. According to the results of this study, apple endophytic bacteria are a potential candidate to control apple rot caused by A. alternata due to cell wall hydrolyzing enzymes, as well as to reduce disease severity. However, further research needs to be carried out on the biochemical basis of their activity against A. alternata.
Untargeted GC-MS metabolomics combined with multivariate statistical analysis as an effective method for discriminating the geographical origin of shrimp paste
Authors: Ji Xiaoyue , Ji Wensu , Ding Linfei
Published: October 2023

Traditional fermented shrimp paste is wildly recognized for its distinctive flavor, exceptional nutritional value, and numerous health benefits. The volatile components of shrimp paste can be influenced by the production process and geographical environment, thereby reflecting its unique characteristics and quality. The objective of this study was to investigate the correlation between shrimp paste produced from different geographical origins and establish a rapid and accurate method for distinguishing them. To accomplish these objectives, the volatiles of shrimp paste from various regions were extracted using headspace solid-phase micro-extraction (HS-SPME) and subsequently analyzed by GC-MS. The data is preprocessed through MS-DIAL and then subjected to multivariate statistical analysis, wherein correlation analysis, principal component analysis (PCA), partial least square-discriminant analysis (PLS-DA), and orthogonal partial least square-discriminant analysis (OPLS-DA) were collectively employed. The findings demonstrate that OPLS-DA exhibits a favorable discriminant region in the context of discriminant analysis. The integration of untargeted GC-MS metabolomics with multivariate statistical analysis offers a rapid and efficient approach for discriminating shrimp paste originating from diverse regions, which circumvents the time-intensive process of volatile compound identification.
Multi-robots dynamic path planning based on improved A* algorithm
Authors: Li Pei zheng , Xie Cong , Guo Xin
Published: October 2023

Intelligent warehousing based on multi-robot system has become the main solution to improve the efficiency of logistics warehousing. At present, the research on intelligent warehouse multi-robots system mainly focuses on task allocation, obstacle avoidance and path planning. In order to solve the traffic congestion problem caused by multiple robots working at the same time in an intelligent warehouse system, a dynamic path planning algorithm for multiple robots based on reservation grid was proposed. Firstly, the collision between robots is prevented by the method of reservation grid and directed graph. Then, the reservation grid is used to generate the traffic congestion map, which displays the congestion status of the current warehouse map in real time. Finally, by improving the A* algorithm, the dynamic path planning of multiple robots is realized, the traffic congestion problem between the robots is solved, and the system efficiency is improved. Simulation experiments are conducted to compare the proposed method with the traditional method, and the effectiveness of the multi-robot path planning method is verified and The range of task allocation parameters under the optimal operating efficiency is tested.
Comparison of the Postoperative Outcomes in Combined Vitrectomy with Sutured Scleral Intraocular Lens Fixation versus Sutureless Intrascleral Haptic Fixation
Authors: Cha Jae Bong , Youn Hyun Chul , Min Jung Kee
Published: October 2023

Purpose
The study aimed to compare the postoperative refraction outcomes between two techniques and evaluate the incidence of iris-optic capture in patients who underwent sutured scleral intraocular lens fixation (sutured SF IOL) and sutureless intrascleral haptic fixation (sutrueless SF IOL; Yamane technique).
Methods
Medical records of patients who underwent two types of SF IOL technique were retrospectively analyzed. The sutured SF IOL group included 24 eyes, whereas the sutureless SF IOL group included 41 eyes. The spherical equivalent (SE) difference (postoperative SE – target SE) was measured using an automatic refractive keratometer 2 months after the surgery. The occurrence of iris-optic capture was also confirmed during the 2-month follow-up after the surgery.
Results
In the sutured SF IOL group, the postoperative SE was − 1.00 ± 1.07, and subtracting the target SE from the postoperative SE obtained − 0.42 ± 0.69, which showed a myopic shift tendency. In the sutureless SF IOL group, the postoperative SE was − 0.34 ± 1.03, and subtracting the target SE from postoperative SE obtained 0.25 ± 0.71, showing a hyperopic shift tendency. Iris-optic capture was noted only in the sutured SF IOL group (4/24 eyes).
Conclusions
With the sutureless SF IOL technique, the setting of refraction is similar to the target refraction before surgery, and IOL-iris irritation is minimized, reducing complications such as iris-optic capture.
A pan-cancer analysis of the core pre-mRNA 3′ end processing factors, and their association with prognosis, tumor microenvironment, and potential targets
Authors: Li Xiangyu , Che Yu , Wang Xiaoyan , Zhu Yong
Published: October 2023

Alternative polyadenylation (APA) is a crucial mechanism for regulating gene expression during pre-mRNA 3′ processing. Pre-mRNA 3′ end processing factors is the main factor involved in this process. However, pre-mRNA 3′ end processing factors in different cancer expression profiles and the relationship between pre-mRNA 3′ end processing factors and tumor microenvironment and the prognosis of the same patient is still unclear. In this study, we conducted a comprehensive exploration of the core pre-mRNA 3′ end processing factors across various cancer types by utilizing common cancer database, and revealing a robust correlation between the expression of these core factors and tumor characteristics. Leveraging advanced bioinformatics databases, we evaluated the expression levels and prognostic relevance of pre-mRNA 3′ end processing factors across pan-cancer tissues. Our extensive pan-cancer analysis revealed unique expression patterns of pre-mRNA 3′ end processing factors in both tumor and adjacent non-tumorous tissues. Notably, we found a significant correlation between the expression levels of pre-mRNA 3′ end processing factors and patient prognosis. Furthermore, we identified strong associations between pre-mRNA 3′ end processing factors expression and various factors, such as stromal, immune, RNA stemness, and DNA stemness scores across pan-cancer tissues. Our data also highlighted a link between the expression of pre-mRNA 3′ end processing factors and sensitivity to specific drugs, including pyrazoloacndine, amonaflide, and chelerythrinede, among others. We found four key pre-mRNA 3′ end processing factors that play a crucial role in mRNA preprocessing. Our study illuminates the potential promotion and inhibition role of pre-mRNA 3′ end processing regulators in the progression of cancer, CPSF2, CPSF3, CSTF2, SYMPK offering valuable insights for future research investigations on these regulators as diagnostic markers and therapeutic targets across pan-cancer.
Improved qARM algorithm for frequent itemsets search in large-scale data sets
Authors: Qi han , Wang liyuan , Fu dianshuo , Gani Abdullah , Gong changqing
Published: October 2023

The existing Quantum Algorithm for Association Rules Mining(qARM) need to set the quantum oracle of data artificially when mining frequent itemsets, which is very time-consuming when dealing with large-scale data. Based on the Cn − X gate and extended Grover algorithm (less-than-oracle), this paper proposes an improved method. In the process of calculating support degree, the original quantum phase estimation algorithm is abandoned, and the combined gate based on the Cn − X gate is used to calculate support, so as to improve the accuracy of calculating support. Then, the extended Grover algorithm is modified to screen the support degree. By using IBM’s Qiskit tool for simulation experiments, the data sets with sizes of 2x2 and 4x4 and fragments 29 − 32 items of data for the dataset Market Basket Optimization.The simulation results shown that,when dealing with large-scale data sets, it is no longer necessary to prepare quantum oracle for all data in advance. In the valid data, its search accuracy can reach 90% on average.
Research on video action recognition based on Tri-Element Comprehensive Perception Attention
Authors: wu yuwei , Li Fei , Zhang Xu
Published: October 2023

When pursuing efficient methods for video action recognition, compared to target detection tasks, the recognition of actions and the temporal sequence of information are intricately connected. So, it often requires more complex models. Additionally, the recognition of action typically involves multiple feature dimensions. How to capture the correlations between different feature dimensions effectively is important for improving the accuracy of action recognition. To face these challenges, we propose a lightweight and effective module called the Tri-Element Comprehensive Perception Attention (TCP) module, which contains three parts: Channel Cross Attention, Spatial Fusion Attention, and Motion Perception Attention. These parts respectively learn information in the channel dimension, spatial dimension, and motion feature dimension through videos, and capture the inter-dimensional correlations effectively. Through extensive experiments, we verify the effectiveness of TCP and its sub-modules in terms of video-level accuracy and frame-level accuracy on the UCF101 and HMDB51 datasets. For example, using 3D Resnet as the backbone network, TCP attention achieves an accuracy of 93.13% and 70.46% on UCF101 and HMDB51 datasets, with improvements of 3.53 and 8.06 percentage points compared to the original model. Compared to advanced methods in this field, TCP demonstrates superior performance in action recognition tasks.
Cyclic Directed Probabilistic Graphical Model: A Proposal Based on Structured Outcomes
Authors: Sirotkin Oleksii
Published: October 2023

In the process of building (structural learning) a probabilistic graphical model from a set of observed data, the directional, cyclic dependencies between the random variables of the model are often found. Existing graphical models such as Bayesian and Markov networks can reflect such dependencies. However, this requires complicating those models, such as adding additional variables or dividing the model graph into separate subgraphs. Herein, we describe a probabilistic graphical model—probabilistic relation network— that allows the direct capture of directional cyclic dependencies during structural learning. This model is based on the simple idea that each sample of the observed data can be represented by an arbitrary graph (structured outcome), which reflects the structure of the dependencies of the variables included in the sample. Each of the outcomes contains only a part of the graphical model structure; however, a complete graph of the probabilistic model is obtained by combining different outcomes. Such a graph, unlike Bayesian and Markov networks, can be directed and can have cycles. We explored the full joint distribution and conditional distribution and conditional independence properties of variables in the proposed model. We defined the algorithms for constructing of the model from the dataset and for calculating the conditional and full joint distributions. We also performed a numerical comparison with Bayesian and Markov networks. This model does not violate the probability axioms, and it supports learning from observed data. Notably, it supports probabilistic inference, making it a prospective tool in data analysis and in expert and design-making applications.
ANALYSIS OF PERIODONTAL TISSUE STATUS OVER TIME DURING THE LOCAL TREATMENT OF PATIENTS WITH GENERALIZED PERIODONTITIS
Authors: Sluchevska Olena , Pavlenko Oleksiy , Mochalov Iurii , Heley Nazariy
Published: October 2023

The objectives of the study was to evaluate the changes in the special indicators of periodontal tissue damage during the local treatment among patients with generalized periodontitis.
Materials and methods. At private medical institution specialized in periodontal treatment, 30 patients (15 men and 15 women, aged 40.23 ± 8.76 years (M = 39.00)) with generalized periodontitis were treated according to the standard treatment protocol. Protocol included ultrasonic removal of tartar and other dental sediments, segmental subgingival scaling, air-abrasive polishing and giving recommendations on hygienic care of the oral cavity. All patients obtained the control of the maximum depth of periodontal pockets, the level of the indices of PMA, CPITN and Green–Vermilion (OHI-S) on at the start of treatment, after 6 months and one year later during follow-up.
Results. Periodical observation and clinical examination showed a partial restoration of the marginal periodontium (gingival) attachment among patients – that was observed by periodontal pocket depth decrease from 9.60 ± 2.07 (M = 10.00) mm to 7.23 ± 1.40 (M = 7.00) mm after 6 months, and to 4.98 ± 0, 88 (M = 5.00) mm a year after the start of treatment. The reduction of the indicator was 4.63 ± 1.43 (M = 4.50) mm. Amnog males recovery took place more intensively which was statistically significant. Initially, PMA index level was 66.38 ± 13.71 (M = 67.50)%, six months later – 32.63 ± 7.48 (M = 32.50)%. A year later – 28.90 ± 8.10 (M = 28.00)%. The reduction of the PMA index was 37.48 ± 9.05 (M = 37.00)%. At the end of the observation period, the reduction in the level of periodontal tissue inflammation among males was 1.2 times more intense than among females which was statistically significant to. At the beginning of observation, the CPITN index was 5.21 ± 0.95 (M = 5.00) with a range of 3.30 to 6.90. After six months – 2.63 ± 0.69 (M = 2.40), after a year – 2.63 ± 0.71 (M = 2.55). Reduction of the CPITN index was 2.59 ± 0.48 (M = 2.50), no gender difference was found. At the beginning of the observation, the OHI-S level was 4.40 ± 0.54 (M = 4.45) and the range was from 3.00 to 5.60. Six months later – 1.80 ± 0.40 (M = 1.80), one year later – 1.79 ± 0.41 (M = 1.80). The index reduction was 2.62 ± 0.48 (M = 2.45), no differences were found among patients of different sexes.
Conclusions. The obtained data indicate uneven effectiveness of local treatment of generalized periodontitis, which includes influence on local factors of disease development. The results suggest a faster recovery of the attachment of the marginal periodontium and a decrease in the intensity of inflammation among male patients and the probable presence of higher physiological reserves of periodontal tissue repair.
Stability of magnesite in the presence of hydrous fluids up to 12 GPa: Insights into subduction zone processes and carbon cycling in the Earth’s mantle
Authors: Sieber Melanie J. , Reichmann Hans Josef , Farla Robert , Koch-Müller Monika
Published: October 2023

Understanding the stability of magnesite in the presence of a hydrous fluid in the Earth’s upper mantle is crucial for modeling the carbon budget and cycle in the deep Earth.

This study elucidates the behavior of magnesite in the presence of hydrous fluids. We examined the brucite-magnesite [Mg(OH)2-MgCO3] system between 1 and 12 GPa by using synchrotron in situ energy-dispersive X-ray diffraction experiments combined with textural observations from quenched experiments employing the falling sphere method. By subjecting magnesite to varying pressure-temperature conditions with controlled fluid proportion, we determined the stability limits of magnesite in the presence of a fluid and periclase.

The observed liquidus provides insights into the fate of magnesite-bearing rocks in subduction zones. Our findings show that magnesite remains stable under typical subduction zone gradients even when infiltrated by hydrous fluids released from dehydration reactions during subduction. We conclude that magnesite can be subducted down to and beyond sub-arc depths. Consequently, our results have important implications for the carbon budget of the Earth’s mantle and its role in regulating atmospheric CO2 levels over geological timescales.
Subsystem non-invertible symmetry operators and defects
Authors: Cao Weiguang , Li Linhao , Yamazaki Masahito , Zheng Yunqin
Published: October 2023

We explore non-invertible symmetries in two-dimensional lattice models with subsystem \mathbb Z_2ℤ2 symmetry. We introduce a subsystem \mathbb Z_2ℤ2-gauging procedure, called the subsystem Kramers-Wannier transformation, which generalizes the ordinary Kramers-Wannier transformation. The corresponding duality operators and defects are constructed by gaugings on the whole or half of the Hilbert space. By gauging twice, we derive fusion rules of duality operators and defects, which enriches ordinary Ising fusion rules with subsystem features. Subsystem Kramers-Wannier duality defects are mobile in both spatial directions, unlike the defects of invertible subsystem symmetries. We finally comment on the anomaly of the subsystem Kramers-Wannier duality symmetry, and discuss its subtleties.
Role of surfactant in the pathogenesis of bronchopulmonary pathology
Authors: Kharitonov M. A. , Rudakov Yu. V. , Salukhov V. V. , Voloshin N. I.
Published: October 2023

Pulmonary surfactant is an important structure of the lungs, providing basic vital functions: reducing alveolar surface tension and facilitating breathing, preventing collapse of the airways and ensuring their patency, protection against infections and pathological environmental factors. Although disturbances of surfactant homeostasis are usually considered in the context of respiratory distress syndrome in preterm infants, it has been established that many lung diseases in adults are accompanied by significant disturbances of surfactant homeostasis. However, preclinical and clinical studies of bronchopulmonary pathology too often overlook the potential role of changes in the qualitative or quantitative composition of pulmonary surfactant in the pathogenesis and development of disease symptoms. In many lung diseases, whether these disturbances in homeostasis are cause or effect remains contravertial field. This review will examine current data on the composition, main functions of pulmonary surfactant and the role of its dysfunction in the pathogenesis of the most frequently encountered bronchopulmonary diseases in the practice of pulmonologists, therapists and rehabilitation specialists, in particular, such as acute respiratory distress syndrome in adults, including associated with a new coronavirus infection, pneumonia of various etiologies and their consequences, bronchial asthma, chronic obstructive pulmonary disease. The review presents the current best practices of replacement therapy with exogenous surfactant preparations and the prospects for pharmacological modulation of surfactant homeostasis disorders in the above nosological forms.
SI Desa (Sistem Informasi Desa): Initiation of an Integrated Village Economic Information System and Data Management by the Provincial Government of East Java
Authors: Budiantoro Risanda A. , Aji Mario Rosario Wisnu , Prayogi Joni , Susanti Anis
Published: October 2023

Implementing regional autonomy gives local governments the authority to provide freedom in regulating and managing their area. Rural development is an essential part of supporting the success of regional development. However, problems were found in the information system and management of village economic data, which resulted in slow village government work processes in collecting information system data and the difficulty for the community to obtain information about the village economy. This study aims to analyze the East Java Provincial Government in initiating the SI Desa Service as a form of providing information system services and computer-based village data management and an integrated website that is easy to access for users. This qualitative research uses an analytical tool as a business model canvas with secondary data because it can develop SI Desa Services through its nine components. The research results by the Provincial Government of East Java through the Community and Village Empowerment Office, which collaborated through a memorandum of understanding with other stakeholders involved in initiating an ideal information system for village economic data management in the SI Desa Service. This integrated service will become a village economic information system and data management that is transparent, accountable, and right on target and can be monitored for its usefulness. The village government can provide excellent service so that all villages integrated with this service can become more resilient and self-sufficient.
Przyrodnicze obszary prawnie chronione w województwie mazowieckim w latach 1999–2022
Authors: Jaglak Elżbieta , Derbin Grzegorz , Rojek Marcin
Published: October 2023

W artykule omówiono zmiany w zakresie przyrodniczych obszarów prawnie chronionych, które zaszły po reformie administracyjnej w 1999 r. Wskazano realizowane przez Samorząd Województwa Mazowieckiego zadania w zakresie polityki regionalnej i zagospodarowania przestrzennego, zgodnie z zasadą zrównoważonego rozwoju. Województwo mazowieckie, powstałe w ramach reformy podziału terytorialnego, objęło swym zasięgiem system obszarów chronionych, w skład którego wchodził Kampinoski Park Narodowy, 164 rezerwaty przyrody, 9 parków krajobrazowych i 29 obszarów chronionego krajobrazu. W ciągu blisko 25 lat utworzono 26 rezerwatów przyrody oraz jeden obszar chronionego krajobrazu. Modyfikacji uległy również granice istniejących form ochrony przyrody. Wraz z wejściem Polski do Unii Europejskiej dokonały się największe zmiany dotyczące obszarów prawnie chronionych. Wdrożenie przepisów prawa unijnego do prawa polskiego skutkowało m.in. wprowadzeniem nowej formy ochrony przyrody – obszarów Natura 2000, uzupełniającej istniejący system obszarów prawnie chronionych. Do marca 2023 r. na terenie województwa mazowieckiego wyznaczonych i zatwierdzonych zostało 80 obszarów sieci Natura 2000. W artykule omówiono, jak kształtowała się pozycja i kompetencje samorządu województwa w zakresie ochrony przyrody na skutek wprowadzanych zmian w prawie. Samorząd województwa przejął kompetencje dotyczące parków krajobrazowych i obszarów chronionego krajobrazu. Na skutek nabytych uprawnień Sejmik Województwa Mazowieckiego m.in. powołał do życia Mazowiecki Zespół Parków Krajobrazowych oraz ustanowił plany ochrony dla parków krajobrazowych. Uszczegółowione zostały granice obszarów chronionego krajobrazu, prowadzone są także bazy danych przestrzennych w zakresie obszarów chronionych. Słowa kluczowe: województwo mazowieckie, ochrona przyrody, obszary prawnie chronione, parki krajobrazowe, obszary chronionego krajobrazu, zielony pierścień
کەلتوری ئوروک و بڵاوبوونەوەی لە کوردستان
Authors: Fatah Othman Tawfeeq , Ahmad Kozad Muhammad
Published: October 2023

–  ئوروک بە سەردەمی بڵاوبوونەوەی شارستانیەت دەبینرێت، کە زۆربەی مێسۆپۆتامیا و زاگرۆسیی کۆنی داپۆشیبو. کوردستانی کۆنیش بەشێک بووە لەو کلتورە و بۆ ماوەیەکی زۆر  کۆنترۆڵی کوردستانی دەکرد لە  ڕێگەی بنکە بازرگانی و کارگێڕییەکانیەوە، بەڵام دانیشتوانی ئەودەمەی کوردستان هەمیشە کلتووری خۆیان پاراستووە. سەرەڕای ئەوەش، دۆزینەوە شوێنەوارییە نوێیەکان لە کوردستانی باشوور زانیاری جیاوازتر پێشکەش دەکەن لەوانەی کە دەربارەی ئەم کەلتوورە لە باشووری مێزۆپۆتامیا زانراوە. ئەم توێژینەوەیە باس لە سەرهەڵدان و ئاوابوونی کەلتوری ئوروک ئەکات و باس لە گرنگترین شوێنەکانی کوردستان ئەکات کە کەرەستەی بەرجەستەی ئەم کەلتورەی لەخۆگرتوە.
Development of Depression Data Sets and a Language Model for Depression Detection: Mixed Methods Study (Preprint)
Authors: Tumaliuan Faye Beatriz , Grepo Lorelie , Jalao Eugene Rex
Published: October 2023

BACKGROUND

Depression detection in social media has gained attention in recent years with the help of natural language processing (NLP) techniques. Because of the low-resource standing of Filipino depression data, valid data sets need to be created to aid various machine learning techniques in depression detection classification tasks.

OBJECTIVE

The primary objective is to build a depression corpus of Philippine Twitter users who were clinically diagnosed with depression by mental health professionals and develop from this a corpus of depression symptoms that can later serve as a baseline for predicting depression symptoms in the Filipino and English languages.

METHODS

The proposed process included the implementation of clinical screening methods with the help of clinical psychologists in the recruitment of study participants who were young adults aged 18 to 30 years. A total of 72 participants were assessed by clinical psychologists and provided their Twitter data: 60 with depression and 12 with no depression. Six participants provided 2 Twitter accounts each, making 78 Twitter accounts. A data set was developed consisting of depression symptom–annotated tweets with 13 depression categories. These were created through manual annotation in a process constructed, guided, and validated by clinical psychologists.

RESULTS

Three annotators completed the process for approximately 79,614 tweets, resulting in a substantial interannotator agreement score of 0.735 using Fleiss κ and a 95.59% psychologist validation score. A word2vec language model was developed using Filipino and English data sets to create a 300-feature word embedding that can be used in various machine learning techniques for NLP.

CONCLUSIONS

This study contributes to depression research by constructing depression data sets from social media to aid NLP in the Philippine setting. These 2 validated data sets can be significant in user detection or tweet-level detection of depression in young adults in further studies.
The Evaluation of Favipiravir Utilization and Clinical Outcome of Inpatients Covid-19 in Secondary Care Hospital, Central Java
Authors: Endah Endriastuti Nialiana , Ekowati Heny , Suryoputri Masita Wulandari
Published: October 2023

Coronavirus Disease 2019 (COVID-19) is a disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The favipiravir is one of the antiviral treatments for COVID-19. There has been limited research done on favipiravir in Indonesia, and there is controversy on the drug's efficacy. This study aims to determine the utilization of favipiravir affected patients with COVID-19. This study was a retrospective data collection method and an observational study. The information was collected from the medical reports of confirmed COVID-19 patients between in March 2020 and June 2021 at the Secondary Care Hospital in Banyumas Regency, Central Java Province, Indonesia. By comparing clinical symptoms before and after using favipiravir, the results of temperature, respiratory rate, and cough symptom parameters were used to evaluate the effects of using favipiravir on clinical symptoms. The total number of 250 patients were qualified the inclusion criteria consisted of 90 patients with severity of illness in mild level, 101 patients had moderate level, and 59 patients with severe level. Most patients reported symptoms of coughing, shortness of breath, weakness, fever, and nausea. The majority of favipiravir patients (n=200; 80%) initiated with a dose of 1600 mg/12 hours, followed by a dose of 600 mg/12 hours, with the longest length of therapy (8-14 days) (n=145; 58%). At all grades of disease severity, statistical analysis of patients showed the significant improvement in cough, fever, and respiratory rate after taking favipiravir (p=0.0001). In conclusion, favipiravir may have beneficial effects on COVID-19 patients in all grade severity of illness.
ZU FRANZ KAFKAS MAGISCHEM REALISMUS: DIE VERWANDLUNG
Authors: Antić Maja
Published: October 2023

Der berühmte Prager Schriftsteller Franz Kafka gehört nicht nur zu den meist interpretierten Schriftstellern der deutschsprachigen, sondern auch der Weltliteratur. Betrachtet man die gewaltige Publikationswelle und Deutungsvielfalt von Kafkas Texten, scheint es so, als ob über seine Prosa fast alles schon gesagt worden sei. Die meisten Literaturkritiker sind sich darin einig, dass Kafkas Werk zeitgeschichtlich zwar dem Expressionismus, ansonsten aber keinem literarischen Programm und keiner literarischen Richtung zugeordnet werden kann. Denn es handelt sich dabei um ein einzigartiges Ereignis in der Weltliteratur. Gleichwohl wird insbesondere Kafkas Erzählung „Die Verwandlung“ (1915) von den Theoretikern des magischen Realismus als Paradebeispiel beziehungsweise Wegbereiter des magischen Realismus angeführt. Vor dem Hintergrund der Tatsache, dass solche Behauptungen in bisherigen Forschungen kaum nachgewiesen worden sind, ist es das Ziel des folgenden Beitrags festzustellen, ob Kafkas Erzählung „Die Verwandlung“ tatsächlich als Beispiel des magischen Realismus klassifiziert werden kann. Dieser Problematik wird hier durch eine komparative Analyse der allgemeinen Eigenschaften der kafkaesken und magisch-realistischen Erzählwelt auf den Grund gegangen. Die Frage, inwieweit sie ein magisch-realistisches Werk ist, wird am Ende dieser Arbeit schlüssig beantwortet sein.
THE NOT-SO-NOBLE SAVAGE: BALKANISM IN MARY EDITH DURHAM’S THROUGH THE LANDS OF THE SERB
Authors: Živković Milica , Petrović Nikola
Published: October 2023

This paper deals with the representation of the Balkans in Mary Edith Durham’s travel novel Through the Lands of the Serb. It aims at analaysing the novel from a postcolonial perspective to expose instances of constructing the Balkans as ‘the other’ within Europe. Maria Todorova’s concept of Balkanism provides a useful theoretical framework to engage with western stereotypes about the Balkans critically. The paper's first part concerns the literary conventions of travel writing, and the second part critically examines some examples of Balkanism. The examples of Balkanism investigated include the depictions of the region as primitive, stuck in the past, impure, infantile, violent, and animal-like. Even though most of the stereotypes are negative, it should be noted that Durham also creates positive stereotypes that are not less harmful.
A REVIEW OF METHODOLOGIES AND METHODS IN LINGUISTIC RESEARCH: DIACHRONIC AND SYNCHRONIC APPROACHES
Authors: Radulović Milica
Published: October 2023

This review of research methodologies and methods in linguistic science has a dual focus. Firstly, the paper provides some essential historical background to the development of the scientific study of language in general and individual languages, including contemporary linguistic inquiry. Secondly, the review attempts to outline the division of labour between linguistic disciplines and models, their respective research methodologies and methods. By including both diachronic and synchronic aspects of linguistic inquiry, the review aims to provide an analyst with a few preliminaries that can be used to situate a linguistic issue in the complex landscape of linguistic theories and research methodologies.
THEORETICAL FRAMEWORK FOR STUDYING TWENTIETH CENTURY ANGLOPHONE LITERATURE
Authors: Tučev Nataša , Ljubinković Dušica
Published: October 2023

This paper provides an overview of theoretical texts and critical essays which enable students to contextualize twentieth century anglophone literature and understand the key concepts, preoccupations and motifs of this literary period. Students are introduced to some seminal works in the field of literary theory and cultural studies, such as those written by Roland Barthes, Louis Althusser, Frantz Fanon, Aime Cesaire or Terry Eagleton. In addition, essays written by Seamus Heaney and Adrienne Rich are included in the syllabus, with a view to representing these poets' explicit poetics and making their poetry more accessible to students. The paper represents briefly each of these texts, while also discussing how they may be applied to the study of literature.