bluuebunny/crossref_metadata_2025 huggingface dataset:
Balancing Leadership and Life: Achieving Success Without Sacrificing Your Well-Being
Authors: Westover Jonathan
Published: December 2024

The notion that leaders must sacrifice personal life to achieve greatness is outdated, as recent research shows it's possible to have a successful career and fulfilled life concurrently. The key is for leaders to reframe their mindsets, redefine success beyond just work accomplishments, and make intentional choices to integrate work and personal priorities. This involves cultivating a "growth mindset" that sees work-life balance as attainable, implementing strategies to thoughtfully blend priorities, and influencing organizational cultures to support distributed, flexible leadership models that empower sustainable success and well-being. With the right approaches leveraging insights from research, leaders at all levels can achieve both impactful results and holistic fulfillment, disproving the myth that great leadership necessitates burnout.
RASIO KEUANGAN MODEL ALTMAN Z”-SCORE PENGARUHNYA TERHADAP FINANCIAL DISTRESS PADA PERUSAHAAN SUB SEKTOR TELEKOMUNIKASI YANG TERDAFTAR DI BURSA EFEK INDONESIA (BEI) TAHUN 2018-2022
Authors: VICTORIA NAEMA , FRIYANTO  , HARITSAR YOSAR
Published: December 2024

The purpose of this study was to determine and analyze the ratio of Working Capital to Total Asset (WCTA), Retained Earnings to Total Asset (RETA), Earning Before Interest and Taxes to Total Asset (EBITTA), and Book Value of Equity to Book Value of Total Debt (BVEBVTD) partially and simultaneously affect Financial Distress in telecommunication sub-sector companies listed on the IDX 2018-2022 period. This study uses descriptive quantitative methods using secondary data from financial statements for five years. The population of this study were all telecommunications sub-sector companies in Indonesia as many as 21 companies with sample withdrawal using purposive sampling method and 16 companies were taken during 2018-2022. The data analysis method used in this research is multiple linear regression analysis using the help of Ms. Excel and SPSS software version 26. The results showed that (1) WCTA has a partial effect on Financial Distress with the results of a significant partial effect (t test) (p=0.000 <0.05). (2) RETA has a partial effect on Financial Distress with significant partial effect results (t test) (p=0.000 <0.05). (3) EBITTA has a partial effect on Financial Distress with the results of a significant partial effect (t test) (p=0.025 <0.05). (4) BVEBVTD has no effect on Financial Distress with the results of a significant partial effect (t test) (p=0.891> 0.05). (5) Simultaneously, WCTA, RETA, EBITTA, BVEBVTD simultaneously affect Financial Distress with the results of simultaneous influence (F test) significant (p=0.000 <0.05).
ATUAÇÃO DO BIBLIOTECÁRIO CLÍNICO EM COMITÊS DE ÉTICA EM PESQUISA
Authors: Dantas Samuel de Carvalho Alves
Published: December 2024

Introdução: o dinamismo informacional na área da saúde, exige que bibliotecários atuantes na área se dediquem a oferecer serviços que vão além da biblioteca. Objetivos: apresentar a importância da atuação do bibliotecário clínico na submissão de projetos de pesquisa junto ao CEP. Método: trata-se de uma pesquisa qualitativa realizada a partir da experiência do bibliotecário enquanto membro do CEP. Resultados: com a atuação do bibliotecário houve um aumento no número de projetos aprovados. Conclusão: o bibliotecário clínico pode ampliar seu campo de atuação para além da biblioteca e mostrar a importância desse profissional vinculado à área da saúde.
ANAIS DO INTREGA 31 - EDIÇÃO 2024
Authors: Souza Amanda Damasceno de , Aguiar Filho Armando Sérgio de
Published: December 2024

Expediente e Editorial dos Suplemento dos Anais do Integra 31-Edição 2024
SEGURANÇA CIBERNÉTICA, UMA ANÁLISE DE INFRAESTRUTURA SEGURA PARA UM E-COMMERCE
Authors: Lima Presleyson , Sá Samuel Alves da Mata , Pessoa Claudio
Published: December 2024

A segurança cibernética é uma ação crucial para a sobrevivência das empresas atualmente. É importante conhecer as novas tendências nos mercados, as novas tecnologias as necessidades e as exceptivas das empresas quando o assunto e segurança, tendo em mente que nenhum sistema é 100% seguro, mas pode-se adotar boas práticas para chegar em um resultado satisfatório. Esse trabalho tem o objetivo apresentar algumas técnicas de invasões mais conhecidas na atualidade e como se prevenir para tornar o ambiente seguro para os usuários do sistema.  Para tal, foi realizado um estudo aplicado utilizando estas técnicas de invasões de sistemas, servidores e banco de dados na área da tecnologia. O trabalho apresenta um modelo teórico que auxilia a adotar boas práticas com o objetivo de diminuir as brechas de segurança.
Las TIC como herramientas pedagógicas para el desarrollo de la motricidad en estudiantes de transición
Authors: Julio Licona Keila , Petro Guzmán Mercedes , Garavito Campillo Érica
Published: December 2024

El presente proyecto de investigación tiene como objetivo contribuir al desarrollo de la motricidad fina y gruesa en los estudiantes del grado transición 02 de la Institución Educativa Lacides C. Bersal, sede Santo Domingo Savio de Lorica, Córdoba, mediante la integración de las Tecnologías de la Información y la Comunicación (TIC) como herramientas pedagógicas. La población objeto de estudio está conformada por 15 estudiantes y dos docentes de preescolar. La investigación se llevará a cabo con un enfoque cualitativo y una metodología de investigación-acción participativa, utilizando técnicas como la observación directa, entrevistas y evaluaciones. Se implementarán recursos didácticos como rondas infantiles y videos animados para fomentar la participación activa y mejorar la motricidad en los niños. Se espera que los resultados preliminares incluyan un aumento significativo en la motivación hacia las actividades motoras, un fortalecimiento de las habilidades motrices y una mayor integración de las TIC en la práctica pedagógica, contribuyendo así a un desarrollo físico y cognitivo de los estudiantes.
Proyectos Etnoeducativos: Un Acercamiento a la Participación Estudiantil y Resignificación de la Escuela Afrocaribeña
Authors: Carmen Paternina Pineda  , Alex Mauricio Díaz
Published: December 2024

Este articulo presenta la revisión de diversos antecedentes nacionales e internacionales asociados con la aplicación de Proyectos Etnoeducativos como estrategias de participación estudiantil para la reafirmación identitaria y resignificación de la escuela Afrocaribeña. Por lo anterior, la metodología se fundamenta en la Revisión Sistemática (RS) según lo propuesto por Kitchenham (2007), en consonancia con el enfoque de las Ciencias Humanas. Basados un proceso que comprende tres etapas: planificación, ejecución y divulgación de la revisión. Con base en lo anterior, este estudio contiene una RS educativa considerando el desarrollo de estrategias de participación Etnoeducativa y reafirmación identitaria dirigido a los estudiantes de secundaria en el departamento de Córdoba. Por tal razón, se ha establecido un protocolo de búsqueda bibliográfica y rastreo de antecedentes investigativos, mediante diferentes bases de datos, tales como; SCOPUS, REDALYC, SCHOLAR y JSTOR, entre otros. Asimismo, revistas educativas y repositorios institucionales de universidad con facultades de educación y ciencias humanas que ofertan postgrados en este ámbito académico.
Environmental Consequence Of The Plastic Waste Management System In The Banadir Region
Authors: Abdi Absirahman
Published: December 2024

This Academy study aims to establish the environmental impact assessment conducted on the solid waste management system in Mogadishu City. This research examines the primary objective of the EIA was to evaluate the potential environmental impacts resulting from the city’s garbage collection and disposal practices. The assessment conducted by the researcher considered various factors, including waste generation, effectiveness of collection, transportation implications, treatment and disposal methods, as well as health and social impacts. Additionally,suggested mitigation actions were also taken into account during the assessment. The outcomes of the EIA clearly emphasized the critical importance of implementing improved waste management procedures to minimize adverse environmental consequences. Recommendations were made for initiatives such as waste reduction and recycling, adopting cleaner technology, and implementing pollution control measures. The findings of this EIA provide valuable insights for the regional environmental agencies and the responsible waste management company in Mogadishu City.These insights will aid in making informed decisions to reduce negative environmental impacts and promote sustainable waste management practices.
Festivals, Identity and Social Stability in Africa: The Example of Calabar Carnival.
Authors: Orfega Jacob Ubwa
Published: December 2024

Festivals are organized periodic celebrations which form the popular culture which encompass the activities and feelings as a result of interaction, across societies of the world. Festivals are signifiers of the cultural identity of spaces within which they occur, thereby becoming tourism events which relate the socio-cultural space of humanity and the contribution of our social identity. This paper explores the role festival tourism plays through identity and exchange of culture, signifying celebrations, promoting community values, ideologies, continuity and social stability. The paper explores identities through examples of performing nationalities and diversity of cultures from Calabar and Lamu carnival of Nigeria. How do festivals contribute to interpreting cultural identity? The paper answers this through discourse of the diverse characteristics of these festivals
Lifecycle Management Of Renewable Energy Systems In Residential Housing Construction
Authors: Shohel Mohammad Shoriful Hossan , Islam Muhammad Mohiul , Prodhan Ripan Kumar , Morshed ASM
Published: December 2024

This study investigates the transformative role of smart grids in integrating renewable energy systems into residential and industrial power networks, emphasizing their potential to enhance energy efficiency, improve grid stability, and address the challenges posed by renewable energy variability. By adopting the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, the study ensures a systematic and transparent approach to the review process. A total of 42 peer-reviewed articles were analyzed, providing comprehensive insights into the technological advancements, challenges, and future prospects of smart grid systems. Key findings reveal that smart grids significantly improve energy efficiency by 20–25%, primarily through the use of real-time monitoring, AI-driven optimization, and advanced energy storage solutions. The review also highlights critical challenges such as high implementation costs, cybersecurity risks, and interoperability issues, which require collaborative efforts among stakeholders to overcome. Additionally, the study underscores the role of microgrids as decentralized extensions of smart grids, offering scalable and resilient solutions for integrating distributed renewable energy sources. This comprehensive review not only validates the importance of smart grids in achieving sustainable energy goals but also provides actionable insights for policymakers, engineers, and researchers aiming to optimize renewable energy integration.
Closing The Productivity Gap In Electric Vehicle Manufacturing: Challenges And Solutions
Authors: Khan Md Rabbe , Islam Md Tahmidul , Islam Kazi Saiful , Hossain Amjad
Published: December 2024

This study provides a systematic review of the challenges and solutions in electric vehicle (EV) manufacturing, addressing key areas such as technological advancements, workforce readiness, supply chain optimization, sustainability practices, and lean manufacturing principles. A total of 86 peer-reviewed articles published between 2015 and 2023 were analyzed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to ensure rigor and transparency. The findings reveal that technological innovations, including automation, artificial intelligence (AI), and digital twin technologies, significantly improve production efficiency and resource optimization, though their adoption remains hindered by high implementation costs and infrastructural incompatibilities. Workforce challenges, including skill mismatches and labor shortages, were identified as critical barriers, particularly in emerging economies where education and training initiatives remain insufficient. Supply chain inefficiencies, driven by raw material dependency and geopolitical risks, continue to disrupt production, despite the potential of predictive analytics and digitalization to enhance resilience. Sustainability practices, such as circular economy strategies and energy-efficient manufacturing processes, were found to reduce environmental impacts and operational costs, though scalability remains a challenge. Finally, lean manufacturing principles emerged as effective solutions for improving productivity and reducing waste, though their success depends on organizational commitment and workforce adaptability.
Cassia alata butanol fraction anti-inflammatory effect on early expression of NFκB and cytokines in DENV-1 infected PBMCs
Authors: Kartika Aisya Alma Asmiranti , Dewi Beti Ernawati , Ariyanto Ibnu Agus , Sudiro Tjahjani Mirawati
Published: December 2024

Cytokine storms impact endothelial cells in vascular tissue, leading to plasma leakage during dengue infection. Several cytokines play important roles in dengue virus (DENV) infection such as TNF-α, IL-6, and IL-10. TNF-α and IL-6 were produced from the NFκB pathway. Prior investigation suggests the potential antiviral activity of butanol fraction derived from Cassia alata, but its potential as anti-inflammation remains unexplored. In this study, peripheral blood mononuclear cells from a healthy donor were infected with DENV-1 and treated with C. alata at 2 × IC50. mRNAs expression was measured by real-time PCR at two time points: 2 and 24 hours post-treatment. The results showed that the expression of NFκB remained relatively constant between 2 and 24 hours post-treatment, while TNF-α and IL-6 in the DENV-1-infected-group were elevated at 24 hours post-treatment. In contrast, IL-10 decreased at 24 hours post-treatment. At 2 hours after treatment, expression of NFκB, TNF-α, IL-6, and IL-10 decreased compared to the untreated group, by 0.084, 0.528, 3.519, and 0.445 fold, respectively. At 24 hours, NFκB expression was slightly down-regulated, while TNF-α, IL-6, and IL-10 were slightly up-regulated. The mRNA expression changes were not statistically significant, but the results showed that the effect of C. alata leaves butanol fraction was stronger at 2 hours post-treatment in the downregulation of TNF-α, IL-6, and IL-10 expression. Further study is needed to evaluate the potential and mechanism of C. alata as an anti-inflammation.
Simulation-based training in transitions from school to workplace learning
Authors: Aarkrog Vibe
Published: December 2024

The article concerns the impact of simulation-based training (SBT) on students’ transition from school-based to workplace-based training in Danish social and healthcare programmes. Denmark has a dual system of vocational education and training, and these transitions are associated with significant dropout. To facilitate the students’ transition, teachers and trainers developed a five-day SBT course conducted in workplaces (care homes). An affiliated research project studied the impact of SBT on how students experienced this transition.
The data included interviews with groups of 4-6 students at each of 12 care homes at the end of the SBT. Furthermore, two surveys were conducted: one at the end of SBT and one at the end of the entire period of workplace-based training (20 weeks). These surveys sought to compare perceptions of the transition and the workplace-based training between students who had participated in SBT and students who had not (control group). The analysis was based on 89 responses to the first survey and 52 responses to the second survey.
The interviews showed that the students were enthusiastic about SBT, highlighting that it had supported their transition by increasing their self-confidence, understanding of theoretical knowledge and of the relationship between theory and practice, reflection skills, and sense of belonging. However, the survey responses found no systematic impact of SBT on the students’ perceptions of these factors. Four explanations are suggested for the divergence between the findings based on interview and survey data: 1. The duration of SBT is too short to have an impact; 2. At the time for answering the surveys the students were preoccupied with performing in the workplace-based training and SBT faded into the background; 3. The SBT students are disappointed with the social community in the ordinary training compared to SBT, and 4. the survey did not directly address SBT.
A Nanotoxicological Approach to the Effects of Metformin and Sodium Metavanadate Co-encapsulated in Polycaprolactone Nanoparticles under the Biological Parameters of Zebrafish (Danio rerio)
Authors: Bittencourt Tiago Queiroz da Mota , Santos Thamiris Pinheiros , Bastos Paulo Eduardo da Silva , Amorim Marleyne José Afonso Accioly Lins , Gomes Sâmara da Silva , Albuquerque Yuri Mateus Lima de , Cadena Pabyton Gonçalves
Published: December 2024

The present study evaluated the sublethal and lethal effects, and heart rate of Danio rerio when exposed to antidiabetic drugs, metformin (M-10), and sodium metavanadate (V-10), their association (MV-10) and the polycaprolactone nanoparticles containing poloxamer 188 with (PPMV-1, PPMV-5, and PPMV-10) or without these antidiabetics (PP-10). Acute toxicity tests were carried out to evaluate these effects. Groups V-10, MV-10, PPMV-5, PPMV-10, and PP-10 had lethal and sublethal, such as effects as pericardial edema. Concerning the heart rate, the PPMV-1, PPMV-5, PPMV-10, and PP-10 groups had a reduction compared to the other groups, indicating toxicity of the constituents of the nanoparticles. PPMV-5, PPMV-10, and PP-10 groups had sublethal and lethal effects depending on the concentration. Antidiabetics were eliminated as a possible cause and the poloxamer 188 is non-toxic at the concentrations used. In the PP-10 group, there was a dynamic of sublethal and lethal effects like the PPMV-10 group. We conclude that the presence of PCL in the formulation of nanoparticles was harmful at the cardiovascular level in embryos and eleuthero-embryos of D. rerio, affecting their development and heart rate, regardless of their concentration. Because of the results obtained, we can conclude that the toxicological evaluation of a nanomaterial is important to anticipate problems in its veterinary application since such results show possible toxicity problems.
The Public Safety and Security Policy Model in African Countries
Authors: Haji Semboja Haji Hatibu , Hafidh Hafidh Ali
Published: December 2024

Most African countries lack comprehensive formal public safety and security policies that articulate a national understanding of guiding principles, values, goals, strategic environment, threats, risks, and challenges. This paper proposes a Public Safety and Security Policy (PSSP) model aimed at assisting African nations in developing robust national policies and implementation plans. The model draws upon a conceptual framework informed by definitions, assumptions, conditions, and relationships among key concepts, addressing critical areas of PSSP development. Informed by extensive literature review and expert consultations, the model incorporates four foundational bases: (1) theoretical underpinnings of public safety and security (PSS) science, (2) regional and global best practices, (3) constitutional and legal frameworks, and (4) existing domestic safety and security systems and practices. This integrated approach offers actionable policy recommendations. The proposed PSSP model facilitates the identification and articulation of clear visions and missions for public safety and security. It also establishes a two-stage institutional reform process, delineating political responsibilities for policy formulation from managerial and operational duties for implementation, thereby enhancing governance and accountability. By addressing real-world challenges faced by African nations, the PSSP model has the potential to contribute significantly to socio-economic development, governance improvement, and the promotion of peace and stability. Its practical impact is evident in how it can help nations navigate complex safety and security landscapes, ensuring alignment with good governance principles such as the rule of law and sustainable development goals.
An Advanced Spherical Bearing Model with FEA Analysis
Authors: Hou Boxiong
Published: December 2024

The mechanical properties of spherical bearing have a direct influence on the seismic performance of bridge construction. Aiming at QZ12500GD spherical bearing, Abaqus finite element analysis software was used for modeling and analysis, and vertical pressure, horizontal thrust and vertical tension were analyzed to study the deformation and stress of the bearing. The model parameters and modeling method of spherical bearing in finite element software analysis are obtained. The analysis results show that this kind of bearing form has good deformation and bearing capacity under the design bearing capacity, and meets the design requirements.
Gene Editing in Cancer Immunotherapy: Mechanisms, Advancements, Limitations and Future Directions
Authors: Ajutor Lawrence John , Agbo Okabeonye Sunday , Adobor Christian Ajiri , Iyoyojie Blessing Aitebiereme , Ugoagwu Kingsley Ugonna , Manawa Oghenevware , Faluyi Osaruese , Ismaila Emmanuel Oluwasegun , Ugwuanyi Oluchi Esther , Adekoya Adepeju Matilda
Published: December 2024

Gene editing has emerged as a transformative approach in cancer immunotherapy. Several gene editing tools have been employed for precise modification of the DNA of immune cells, enhancing their ability to target and eliminate cancer cells. This review examines the evolution and applications of key gene-editing tools, such as CRISPR-Cas9, TALENs, ZFNs, and recent innovations like base and prime editing in the field of cancer immunotherapy.
Promising results have been observed in therapies such as CAR-T and tumor-infiltrating lymphocyte (TIL) treatments, which have shown success in cancers like leukemia and lymphoma. These technologies improve immune system function by disrupting checkpoints, boosting cytokine production, and modifying tumor microenvironments.
Significant clinical trials have demonstrated promising outcomes, such as CRISPR-Cas9-engineered T cells targeting refractory cancers, which showed improved efficacy and safety. However, despite these advancements, there have been limitations, including off-target effects, delivery inefficiencies, immunogenicity, and ethical concerns, alongside the high costs that hinder widespread adoption.
Future directions for gene editing in cancer therapy include the integration of AI and machine learning to enhance target accuracy and guide RNA design, as well as novel gene-editing systems such as the I-C Cascade-Cas3, which facilitates large-scale genomic deletions. Furthermore, CRISPR-based epigenome editing holds promise for further advancing cancer therapies. These innovations, combined with optimized delivery methods, are expected to improve the precision, efficacy, and accessibility of gene editing in cancer immunotherapy.
Causality between Agricultural Investments, Inflation and Interest Rates in Nigeria
Authors: I. A Maduike, , Nwaru J. C. , Iheke O. R. , Eze C. C. , Ibeagwa O. B.
Published: December 2024

This study examined the linkages between agricultural investment (comprising Foreign Direct Investment in agriculture, government investment in agriculture and private sector investment in agriculture), inflation rate and interest rate in Nigeria (1981 – 2020). Data for the study were sourced from Central Bank of Nigeria (CBN) and, Food and Agriculture Organization (FAO), and analyzed using Granger causality tests. Results showed that government investment in agriculture (p < 0.05) and private sector investment in agriculture (p < 0.1) has significant uni-directional causality to the level of agricultural foreign direct investment in Nigeria. Also there was uni-directional causality from inflation rate to interest rate (significant at 10%). It was recommended that public and private sectors’ investment in agriculture should be strategic to attract foreign investments in order to boost the productivity of agriculture in Nigeria.
Oxygen Dissociation Curve: Reviewing the Physiology and Influencing Factors
Authors: Sil Arijit
Published: December 2024

The oxyhemoglobin dissociation curve is a vital tool for comprehending how blood transports and releases oxygen, that is carried throughout the body both in bound form with protein (hemoglobin) and dissolved in plasma. The oxyhemoglobin dissociation curve describes the relationship of oxygen saturation (SaO2) and partial pressure of oxygen in the blood (PaO2) (Patel & Jose 2024).
The oxygen dissociation is affected by factors like pH, CO2, 2,3-DPG, CO. This paper discusses the significance of factors like pH, CO2, 2,3-DPG, CO, and structurally different haemoglobin which have a considerable effect on the affinity of haemoglobin for oxygen and determine how efficiently oxygen is supplied to the body cells.
Managerial Strategies for Alleviating Occupational Stress to Enhance Job Performance among Secondary School Teachers in Mwanza Region, Tanzania
Authors: Francis Nyakeko
Published: December 2024

This study examined the effectiveness of managerial interventions in mitigating occupational stress in a bid to enhance job performance among secondary school teachers in Mwanza City and Ilemela Municipality of Mwanza region in Tanzania. Data were gathered from 462 participants comprising Heads of Secondary School (HSS), Secondary School Teachers (SSTs), Ward Education Officers (WEOs) and District Education Officers (DEOs) from December 2021 to June 2023. Employing a mixed-methods approach, the study used a questionnaire featuring both open-ended and closed-ended questions to collect qualitative and quantitative data, respectively. Additionally, interviews held with purposively selected teachers to offer comprehensive insights into the research problem. The recognition among employees, fostering superior-subordinate relationships, delegation of authority, on-the-job training and improvement of the work environment emerged as effective managerial interventions for ameliorating occupational stress among secondary school teachers. This research contributes valuable insights that educational administrators and policymakers can capitalise on in implementing strategies aimed to support teacher well-being and strengthen educational outcomes.
The Poor Performance of Students with Hearing Impairments in Tanzania: A Case Study of Iringa Girls' Secondary School
Authors: Francis Nyakeko
Published: December 2024

This study aimed to identify factors contributing to the poor performance of students with hearing impairments in Tanzania's secondary schools."Specifically, the study examined the challenges the teachers, school administrators and students face in supporting academic achievement. The study involved 23 participants including DQAOs, DEOs, the head of school, teachers and students with hearing impairments.  Data were collected using document review, observation, and interviews with District Quality Assurance Officers and the head of school. Additionally, the study gathered primary data from teachers and students with hearing impairments, who participated focus group discussions. The study identified significant barriers to include a shortage of specialised teachers, inadequate teaching and learning facilities and limited support from school leadership. Furthermore, the study suggests that supporting inclusive education and improving academic performance for students with hearing impairments required initiatives such as more training for school administrators, more funding, and extensive support networks.
A Modified Algorithm to Find Longest Common Subsequences and Optimizing Space, Time
Authors: Thilaganathan S. , Jeyamugan T.
Published: December 2024

In the study of Longest Common Subsequence (LCS) is an important topic and an important component in the application of Computational Mathematics. The LCS problem is to find a subsequence which is common to at least two or more given sequences. The largest length subsequence is called as LCS. Due to high demands for computational time, power and memory, this paper introduces a new efficient modified algorithm to find the longest common subsequences in two different sequences X and Y. The sequences represented in memory in vertical and horizontal directions. An array is established where each sequence assigned in this array. A new node is added to it for every match between two sequences. If two or more matches in different locations in Sequence Y share the same in X, the corresponding node will construct the LCS in various ways. Continuing in this process we obtain a group of LCS between the sequences X and Y. The proposed modified algorithm has been implemented and tested using Matlab language. This algorithm shows very good speedups and indicated efficiently minimizing the space complexity and optimizing the time taken to execute and impressive improvements has been achieved.
Proximate, Vitamin and Antinutritional Content of Fresh and Roasted Tympanotonus fuscatus Harvested from Bundu Creek, Rivers State, Nigeria
Authors: B.G Ibiama, , F.N Okwakpam, , O.O Ikiriko, , D. Elendu, , B.A. Amadi,
Published: December 2024

fuscatus (periwinkle) is an invertebrate of the gastropoda class, dominantly found in brackish waters of tropical and subtropical regions. This study compared the nutritional and anti-nutritional content of T. fuscatus from Bundu Creek, and the impact of processing on its nutritional and anti-nutritional parameters. Fresh and roasted T. fuscatus samples were purchased from fishermen at Bundu Creek Port-Harcourt, Rivers State. Fresh T. fuscatus were deshelled using a clean plier and fleshy portion was collected and washed with distilled water whereas, roasted samples were placed in an oven at 106°C for 2hours. Both samples were homogenized using a preheated mortar and pestle which further proceeded for analysis. Proximate composition, anti-nutrients, minerals and vitamin contents were determined using standard analytical procedures. The percentage proximate composition showed that roasted periwinkles were significantly (p<0.05) higher in protein (58.57±0.29% -13.90±0.03%), lipid (5.50±0.00%- 2.26±0.03%), carbohydrates (11.64±0.09%-5.10±0.03%), ash (10.80±0.06%-5.73±0.03%) and crude fibre content (5.54±0.16%-2.84±0.08%) when compared with fresh samples which had an increased moisture content (7.94±0.04%-70.19±0.05%). The anti-nutritional component saponins was significantly (p<0.05) increased in roasted samples (15.28±0.01%-3.80±0.00%) when compared with fresh samples. There was no measurable trace of Cyanogenic glycosides in both states. The roasting process significantly (p<0.05) reduced the presence of oxalate, phytate and flavonoids. For mineral content, Zinc, Iron, Magnesium and Phosphorus were significantly (p<0.05) higher in roasted samples than Calcium. No significant difference was observed in vitamin content for the fresh and roasted samples. This research has shown that processing generally, helped to amplify the nutritional properties of T. fuscatus.
Development of a Collection Kit for Efficient Isolation of SARS-CoV-2 RNA from Urine and Stool Samples
Authors: Abdul-Sada Hussein K. , Jawad Rasha N.
Published: December 2024

Background Information: Consider adding a brief sentence about the significance of detecting SARS-CoV-2 in urine and stool samples. For example, mention how these samples can serve as alternative sources for diagnosis, potentially leading to better patient outcomes.
Objective Statement: This study aimed to develop a collection kit for the effective extraction of SARS-CoV-2 RNA from urine and stool samples. The study presents a significant advancement in the field of viral diagnostics by introducing a novel collection kit specifically designed for the extraction of SARS-CoV-2 RNA from urine and stool samples. The demonstrated efficacy of the kit in isolating the virus with high success rates from alternative biological fluids, as well as the superior RNA.
Methodology: The kit contains a swab of medical polyester and three tubes, two of them used to inactivate the virus, one contains 3% phenol and the other 1% phenol, and the third tube contains 2 ml of (PBS) Phosphate Buffer Saline added to it 4% of skim milk. Urine or stool samples from Covid-19 patients who reported positive by nasopharyngeal swab during RT-PCR was adde consequently in these three tubes then assessed through RT-PCR testing.
Results: The kit succeeded in isolating coronavirus from the urine and stool of patients who reported positive by nasopharyngeal samples. From 20 positive nasopharyngeal samples, there was 18 (90%) of them were positive by using stool sample using this kit, and 15 (75%) of them were give positive result when urine samples were used by this kit. The concentration of RNA of coronavirus which was isolated from urine and feces was higher than in the nasopharyngeal swab during RT-PCR. Mean Ct value of the 20 samples was showed that the mean Ct of nasopharyngeal was 31.5, while urine and stool samples Ct means less concentration of virus. were 25.75 and 24.32 respectively. High The kit was able to serve RNA that was isolated from urine and feces for about 5,10, and 30 days in a percentage of 100%, 94.1%, and 94.1% respectively.
Conclusion and Implications: The kit is produce to confirm that the patient is infected with by COVID-19 and to preserve the virus in stool or urine samples of the infected person for a long period until laboratory tests through RT-PCR are conducted on the samples. The kit showed great ability to test SARS-CoV-2, even if it was at low concentrations of virus compared to the examination of nasopharyngeal swabs.
Hierarchic Control for a Two-Stroke Linear System with Missing Data
Authors: NIKIEMA Ferdinand , SOMA Mifiamba , KERE Moumini , SAWADOGO Somdouda
Published: December 2024

In this paper, we study a new hierarchical control problem for a linear two-stroke missing data problem, adjoint to an age and space structured single species population dynamics problem. We show that there are two controls such that the first control, called the follower, solves an optimal control problem which consists in bringing the state of the two-stroke linear system to a desired state, and the second control, called the leader, solves a null controllability problem. The results are obtained by means of an observability inequality associated with a homogeneous Dirichlet boundary condition.
Post Covid-19 Hygienic Behavior and Public Perception in Zanzibar in Relation to Future Pandemic
Authors: Salum Salum Seif , Moh’d Saleh Khalfan , Haji Ummulkulthum Chamda
Published: December 2024

Background: During the COVID-19 Pandemic, hygiene behavior significantly changed due to the implementation of the World Health Organization strategies intended to combat coronavirus           transmission. The goal of this study is to assess the post-COVID-19 hygienic behaviors and public perception in Zanzibar.
Methods: This cross-sectional study was conducted in Zanzibar town between March 28 and May 19, 2021. A convenience sampling method was applied to recruit interested participants.  A structured questionnaire was used for the interview and a checklist for direct assessment.  The data was analyzed using Microsoft Excel and the Statistical Package for Social Sciences (SPSS) Version 20.  
Results: Among 299 enrolled respondents, residents were 78.9% and non-residents were 20.7%. 49.2% of the respondents were between 18 and 28 years old. 53.8% were males and 46.2% females. There was a significant difference in the source of COVID-19 information between residents and non-residents (p-value = 0.0000000000028) p<0.05.  Television 61% and radio 34.7% were the main information source for residents as television 76.3% and social media 15% for non-residents.  84.3% of the residents and 58.7% of the non-residents expressed fear of the presence of COVID-19 cases in neighboring countries (p-value = 0.00000741) p<0.05. 59.9% of the residents and 75.4 % of the non-residents believed that Zanzibar was not safe from COVID-19, (p-value = 0.0694) p>0.05. Of 47.5% of respondents believed that the imposition of preventive measures was the main factor that prevented Zanzibar from being strongly hit by COVID-19. 
Conclusion:  There was positive behavior and perception during post-COVID-19.  For sustainable modest hygienic practices, there is a need to shift from fear-driven hygienic behavioral changes to awareness-driven through the use of appropriate sources of information for community education and keep maintaining hand-washing practices at least at public institutions
Evaluating the Environmental & Socioeconomic Effects of Insufficient Water & Sanitation in Afghanistan
Authors: Rezaie Mohammad , Azizi Mohammad Imran , Rezaie Mohammad Abbas
Published: December 2024

This study explores the current access to drinking water and sanitation in Afghanistan and identifies considerable differences in the coverage between urban and rural settings. About 30-33% of the population has access to safely managed drinking water sources and 68% has access to improved sanitation facilities. The study used the most recent and relevant literature, reports, and online data portals to explore the current water and sanitation situation and depict the importance of country-specific intervention strategies to address these critical challenges. The study notes the harmful social and environmental results of inadequate water and sanitation, including a threat to sensitive ecosystems, the prevalence of waterborne disease, and hunger. The Afghan government and development partners continue to work towards improving these conditions, but deficiencies in finance, institutional capacity, stakeholder coordination, and policy implementation remain. Local ownership and participation have been identified as key factors in ensuring the sustainability of the interventions in this research. The results underscore that community empowerment can potentially yield better results if its inclusion is ensured. The study highlights the need for greater community engagement in developing water and sanitation projects and gender-specific strategies, given that inadequate facilities often adversely affect women and girls. The study concludes with its recommendations to improve water and sanitation services through community-driven technologies, blended financing models, and need-based capacity-building initiatives. Through strengthened stakeholder collaboration and high priority on gender inclusion, Afghanistan can greatly improve access to safe and sustainable water and sanitation facilities and services, helping the country advance sustainable development progress in this vital sector.
Nelarabine in T-Cell Acute Lymphoblastic Leukemia: An Analysis of the Literature
Authors: Karrar Hani Raka , Nouh Mahmoud Ismail , Kufyah Maria Talal , Alshehri Amal Mueidh , Zuhair Rahaf Mohammed , Alanazi Ahad Hamdi , Alahmari Faisal Abdulrahman , Alqarni Mohammed Yahya Bakhan , Alzahrani Saleh Jabbar Saleh , Ghzwani Amera Gassem , Almuqati Abdulrahman Olayan , Aldhuwayhi Muhannad Ibrahim , Alharbi Turki Othman Ali , Alotaibi Khloud Mubark
Published: December 2024

T-cell acute lymphoblastic leukemia (T-ALL) represents a highly aggressive hematological malignancy predominantly affecting adolescents and young adults. Despite advancements in treatment modalities, including multi-agent chemotherapy, the prognosis remains unfavorable, particularly for individuals with relapsed or refractory disease. The intricate nature of T-ALL, marked by genetic heterogeneity and early dissemination, necessitates the investigation of novel therapeutic agents to improve treatment efficacy and enhance survival rates. Standard intervention primarily encompasses chemotherapy and, in some instances, stem cell transplantation; however, the occurrence of early relapse emphasizes the critical need for alternative therapies that target the fundamental biology of T-ALL.Recent advancements in understanding the molecular and genetic underpinnings of T-ALL have facilitated the formulation of personalized therapeutic approaches and immunotherapeutic strategies. Nelarabine, a pro-drug of arabinosyl guanine (ara-G), has emerged as a promising candidate for relapsed or refractory scenarios. This agent specifically targets T-cells, integrating into their DNA to obstruct synthesis and repair processes, thereby effectively eradicating rapidly proliferating cancer cells. Laboratory investigations highlight nelarabine's robust anti-leukemic properties, while early clinical trials reveal substantial recovery rates, especially among pediatric patients. Notably, a pivotal study conducted by the Children’s Oncology Group demonstrated considerable efficacy in the treatment of relapsed T-ALL, particularly when administered in conjunction with corticosteroids and vincristine, indicating improved treatment outcomes
Evaluation of the Antibacterial Activity of Solanum torvum Fruit Extracts on Hospital Strains of Enterobacteria
Authors: Claude-Charlène KEKE Margery , Fernique KONAN Kouadio , Constantin OKOU Obou , Mathieu KRA Adou Koffi , Nathalie GUESSENND
Published: December 2024

Enterobacteriaceae are among the most pervasive bacteria globally and are the most commonly identified in clinical consultations. It is unfortunate that these disease-causing germs are now increasingly resistant to the standard antibiotics that are generally used. In order to propose probable therapeutic alternatives, this study focused on evaluating the antibacterial activity of Solanum torvum fruits on a few strains of enterobacteria. To this end, 70% hydroethanolic and 100% ethanolic extracts were prepared from Solanum torvum fruits and tested, respectively and separately, on a reference strain of Escherichia coli (ATCC), on sensitive strains of Salmonella sp. and Shigella sp., and on resistant strains of Escherichia coli, Citrobacter koseri, Enterobacter cloacae, Klebsiella pneumoniae, Proteus mirabilis, and Citrobacter freundii. All susceptible and resistant strains of Enterobacteriaceae were isolated from various biological products of patients. The results demonstrated that these extracts exhibited antibacterial activity with a bactericidal effect on these strains. These extracts could therefore be employed in the manufacture of phytomedicines for the treatment of enterobacterial infections.
Preferences for Biologic Treatment in Patients With Psoriatic Arthritis: A Discrete Choice Experiment
Authors: Sumpton Daniel , Kelly Ayano , Craig Jonathan C. , Hassett Geraldine , Kane Barry , Oliffe Michael , Tong Allison , Howell Martin
Published: September 2021

Objective

We aimed to assess patient preferences for the characteristics and outcomes of biologic and targeted synthetic disease‐modifying antirheumatic drugs (DMARDs) to manage psoriatic arthritis.

Methods

We conducted a discrete choice experiment in patients with psoriatic arthritis from 3 rheumatology centers in Sydney, Australia. We assessed preferences for different attributes of biologic medications. The route and frequency of medications had a range of 5 levels, and the following 7 attributes had a range of 3 levels: the ability to attend to normal activities, improvements in joint pain, enthesitis and skin disease, chance of disease remission, risk of infection, and risk of severe adverse events. Multinomial logit models including a latent class model were used to calculate preferences.

Results

Of the 150 participants, 58.3% were female, with a median age of 53.5 years. The attributes in order of preference using the β coefficient in absolute values (95% confidence interval [95% CI]) were as follows: oral route compared to subcutaneous and intravenous routes (β coefficient 1.00 [fixed parameter]), avoiding severe side effects (β coefficient 0.72 [95% CI 0.50, 0.95]), increasing ability to attend to normal activities (β coefficient 0.66 [95% CI 0.36, 0.96]), avoiding infections (β coefficient 0.38 [95% CI 0.23, 0.53]), improvement in enthesitis pain (β coefficient 0.28 [95% CI 0.20, 0.36]), improvement in psoriasis (β coefficient 0.28 [95% CI 0.20, 0.36]), increasing chance of remission (β coefficient 0.27 [95% CI 0.19, 0.36]), and improvement in joint pain (β coefficient 0.26 [95% CI 0.00, 0.52]).

Conclusion

When choosing biologic medications, patients with psoriatic arthritis preferred oral medications. Patients prioritized avoiding severe complications, maintaining the ability to attend to work and normal activities, and avoiding infection over clinical measures of efficacy.
Quantum Dots Encapsulated by ZrO2 Enhance the Stability of Perovskite Solar Cells
Authors: Wang Kai , Yao Ruohe , Shen Pei , Fang Yi , Chen Ling , Wang Hong
Published: September 2021

In the last several years, perovskite solar cells (PSCs) are faced with big problems in the stability issues, which also occur in the Interface modification materials. Herein, CsPbBr1.5I1.5 quantum dots (QDs) encapsulated in ZrO2 sol is introduced to improve device stability to some extent. The encapsulated QDs can improve the morphology of the perovskite layer and effectively passivate the perovskite film. The device fabricated by CsPbBr1.5I1.5 QDs encapsulated achieves a power conversion efficiency (PCE) of 21.23%, corresponding to 18.86% for the unmodified control devices. The performance of the device based on CsPbBr1.5I1.5/ZrO2 nanocomposites modified remains 81.8% of initial PCE after 500 h.
Surface Functionalization of Spruce‐Derived Cellulose Scaffold for Glycoprotein Separation
Authors: Li Kai , Wang Shennan , Koskela Salla , Zhou Qi
Published: September 2021

Protein immobilization on a stationary phase, such as nanocelluloses, is widely used in biodiagnostic, biocatalytic, and bioseparation applications. With the top‐down approach which utilizes the native hardwood honeycomb structure, mesoporous cellulose scaffolds can be fabricated without the need for energy‐consuming production and bottom‐up assembly of nanocelluloses. However, this approach is difficult for preparing softwood‐based cellulose scaffolds due to the disintegration of wood cells after complete delignification. Herein, for the first time the use of spruce softwood with a homogenous cellular structure of longitudinally positioned and top‐to‐bottom joined tracheids is explored as a scaffold for protein immobilization. 1,4‐butanediol diglycidyl ether is utilized to crosslink cell wall polysaccharides before the delignification step, thus improving the adhesion between tracheids. The native cellular structure of spruce is well preserved after the complete removal of lignin, enabling the successful production of a highly mesoporous and mechanically robust spruce‐derived cellulose scaffold with exceptionally high specific surface area (219 m2 g−1). Further amination of the cellulose scaffold allows covalent immobilization of functional biomolecules, such as a lectin protein concanavalin A (Con A) and biotin, on the lumen surfaces and inside the porous cell wall. The Con A immobilized scaffold demonstrates native glycoprotein‐binding activity and possible glycoprotein separation application.