bluuebunny/crossref_metadata_2025 huggingface dataset:
Hydroinformatics opening new horizons: union of computational hydraulics and artificial intelligence
Authors: Babovic V. , Minns A. W.
Published: December 2022

The strengthening dominance of electronics over past several decades has resulted in an almost total dominance of digital representation of the hydro-environment. Recognizing these developments, Mike Abbott introduced the notion of electronic encapsulation of information and knowledge. The act of encapsulating information and knowledge changes the very nature of the information and knowledge involved. Suffice to say that electronic encapsulation must also change the way in which an engineer accesses and uses the available information and knowledge. There is a shift in paradigm away from a model-based approach to a more data-based approach. Adopting such foundational considerations as its core, hydroinformatics opened research to the latest IT developments in the fields of artificial intelligence (including machine learning, evolutionary algorithms and artificial neural networks), artificial life, cellular or finite-state automata and other, previously unrelated sciences and technologies. Through studying and exploiting elements of these, at first sight unrelated, sciences, hydroinformatics produced new and innovative solutions to hydraulic and hydrological problems, as represented by real-time control and diagnosis, real-time forecasting, calibration of numerical models, data analysis and parameter estimation. In particular, the new approaches are able to generate important components of physically based, modelling systems by inducing models or sub-models of individual physical processes based only upon measured data. These (sub)models may then replace whole systems of complex, non-linear, differential equations that would otherwise require great skills from the modeller to calibrate, and powerful computing devices to solve. This chapter captures evolution of data science and AI within the field of hydroinformatics and provides an outline of the present state-of-affairs together with some ideas for future directions. The chapter outlines tangible solutions that have been applied by the hydroinformatics community to address specific challenges in hydro-environmental systems.
Hydroinformatics education at IHE Delft: past and future
Authors: Solomatine D. P. , Price R. K. , Jonoski A. , Popescu I. , Bhattacharya B. , Alfonso Segura L. , Corzo Perez G. , van Andel S. J. , Bertini C.
Published: December 2022

From the very beginning of introducing hydroinformatics as a new discipline of research and practice, Mike Abbott worked together with his collaborators on establishing a supporting educational programme at post-graduate level. This chapter presents the establishment of the first hydroinformatics post-graduate programme at IHE Delft, in the Netherlands, later offered as an MSc degree in water science and engineering with specialization in hydroinformatics. The curriculum and the set-up of the programme are described, together with their developments over the last three decades. This programme has significantly benefited from the unique characteristics of IHE Delft: The institute is specifically oriented to providing water education to participants from the Global South, and, at the same time, it operates within a network of diverse organizations engaged in research and practice of water management in the Netherlands and Europe. The hydroinformatics programme has therefore benefited from contributions of top experts from such institutions who have taken roles as invited lecturers, as well as MSc and PhD mentors and supervisors, very often on water-related topics originating from-, or relevant for students' home countries. Challenges for maintaining relevant attractive hydroinformatics curriculum have come from continuous developments in information and communication technologies (ICTs), need for balancing ICT-related and water-related subjects, while still imparting knowledge regarding the primary role of hydroinformatics as an integrating discipline needed for supporting efficient-, but also transparent and inclusive water-related decision making. The associated PhD programme in hydroinformatics and some related Master programmes at IHE Delft are also briefly introduced. The chapter also presents an overview of hydroinformatics-related education at other universities around the world. The concluding section presents an outlook for future hydroinformatics education in which next to its water and informatics components, its social dimension and integrative purpose will become even more important.
Aspectos éticos sobre o acesso à informação e a dinâmica do compartilhamento da desinformação nas campanhas eleitorais na internet
Authors: Assis Stella Schwanz Dias de , Gerlin Meri Nadia Marques
Published: December 2022

A temática propaganda eleitoral na internet traz consigo uma extensa gama de questionamentos. Enquanto, por um lado, proporciona uma maior aproximação do eleitor com as informações sobre o processo político, por outro, potencializa a disseminação de notícias falsas, responsáveis, em grande parte, por manipular a intenção de votos de uma nação. Essa problemática vai além da discussão sobre desinformação, não é apenas sobre notícias falsas versus verdadeiras. Com o objetivo de analisar a relação entre o acesso à informação e os aspectos éticos da informação, a presente pesquisa, exploratória e qualitativa, tem como foco a constituição de um estudo bibliográfico que vai se consolidando em torno das campanhas eleitorais no meio digital. Trata-se de refletir criticamente sobre as formas de legitimação da desinformação capazes de influenciar a sociedade, em uma realidade em que uma mentira contada várias vezes pode tornar-se uma verdade para quem a escuta, e é neste ponto que se enxerga um risco real ao processo democrático.
The JAK-STAT Signaling Pathway in Epilepsy
Authors: Sun Huaiyu , Ma Di , Cheng Yu , Li Jiaai , Zhang Wuqiong , Jiang Ting , Li Zhaoran , Li Xuewei , Meng Hongmei
Published: December 2022

Epilepsy is defined as spontaneous recurrent seizures in the brain. There is increasing evidence
that inflammatory mediators and immune cells are involved in epileptic seizures. As more research
is done on inflammatory factors and immune cells in epilepsy, new targets for the treatment of
epilepsy will be revealed. The Janus kinase-signal transducer and transcriptional activator (JAKSTAT)
signaling pathway is strongly associated with many immune and inflammatory diseases, At
present, more and more studies have found that the JAK-STAT pathway is involved in the development
and development of epilepsy, indicating the JAK-STAT pathway’s potential promise as a target
in epilepsy treatment. In this review, we discuss the composition, activation, and regulation of the
JAK-STAT pathway and the relationship between the JAK-STAT pathway and epilepsy. In addition,
we summarize the common clinical inhibitors of JAK and STAT that we would expect to be used in
epilepsy treatment in the future.
Identification of Novel PPAR-β/δ Agonists from Kaempferol, Quercetin, and Resveratrol Derivatives by Targeting Cancer: An Integrative Molecular
Docking and Dynamics Simulation Approach
Authors: Ballav Sangeeta , Lokhande Kiran Bharat , Sahu Vishal Kumar , Yadav Rohit Singh , Swamy K. Venkateswara , Basu Soumya
Published: December 2022

Background:

Drug resistance in cancer is a serious threat to human well-being. There is a dire
need to develop novel and efficient lead molecules to treat the disease. In lieu of anti-cancer activities,
Peroxisome proliferator–activated receptors (PPARs)-β/δ proven to be potential therapeutic targets
against cancer. However, there are yet no PPAR-β/δ agonists reported for clinical use.

Objective:

The present study features in silico screening and identification of 8708 derivatives based on
backbone of natural compounds like Kaempferol, Quercetin and Resveratrol against PPAR-β/δ using
molecular docking, and molecular dynamics (MD) simulations.

Methods:

Initial screening of 8708 derivatives was done by recruiting Lipinski’s rule of five. Docking
calculations were assessed through FlexX software tool. GROMACS was used to analyze dynamic perturbations
and binding free energy (MM/GBSA) analysis of the top compounds. SwissADME was used to
analyze pharmacokinetic properties.

Results:

The results of molecular docking indicated that 2-[2-(2,4-Dihydroxyphenyl)-2-
oxoethoxy]benzoate (DOB), (E)-1-(3,4,5-Trihydroxyphenyl)-3-(3,4-dihydroxyphenyl) propene (TDP)
and 2-Hydroxy-3-(2,6,7-trihydroxy-3-oxo-3H-xanthen-9-YL) benzoic acid (HTOB); respective derivatives
of Kaempferol, Resveratrol and Quercetin strongly binds to the active site residues of PPAR-β/δ.
Furthermore, ADME (absorption, distribution, metabolism & excretion) profile conferred their high druglikeness
properties. On monitoring their dynamic perturbations, HTOB acquired the most favorable interaction
and stability within the vicinity of PPAR-β/δ protein.

Conclusion:

These outcomes constitute preliminary studies and the obtained lead derivatives could be
great options to treat various types of cancer and formulate as oral drug candidates.
Pollution Prevention Assessments: Approaches and Case Histories
Authors: Kumar Ashok , Harsha Madiraju Saisantosh Vamshi , Kuruppuarachchi Lakshika Nishadhi
Published: December 2022

The pollution prevention (P2) approach known as source reduction is being
used worldwide to reduce the deleterious effects on human health and the environment
due to the contaminants released from a variety of industrial sources. This chapter
focuses on the concept of pollution prevention approaches undertaken by the U.S.EPA.
P2 approach is discussed by applying the concept of energy efficiency, energy savings,
greenhouse gas emission (GHG) reductions, waste reduction, and stormwater
management to local schools, restaurants, hospitals, and the industrial sector in Ohio,
USA. Several publicly available tools were used to analyze data collected during
assessments. The major tools used are the Energy Assessment Spreadsheet tool
(developed by Air Pollution Research Group at the College of Engineering, The
University of Toledo, Ohio, USA) for the energy savings and Economic Input Life
Cycle Assessment tool (developed by researchers at the Green Design Institute of
Carnegie Mellon University) for the estimation of environmental emissions from
industrial activities.These approaches result in the reduction of financial costs for waste
management, cleanup, health problems, and environmental damage. Outcomes of
pollution prevention activities are knowledge-based, behavioral, health-related, or
environmental, which includes decreased exposure to toxins, conservation of natural
resources, decreased release of toxins to the environment, and cost savings. The chapter
presents case studies that focused on energy, greywater reuse, and food waste diversion
from landfills.
The Role of Product and Service Quality in A Competitive Position: Depositors’ Satisfaction
Authors: Jusni Jusni , Aswan Andi , Baharuddin Gunawan , Abdul Rahim Hafizah
Published: December 2022

AbstractThe study seeks how the Regional Development Banks operating in South and West Sulawesi maintain and attract depositors by evaluating the deposit products and banking service quality that have an impact on depositors' satisfaction. The study collected data using questionnaires distributed to 100 depositors owned by three Regional Development Banks. The data collected is then used to analyze the constructs of savings products, quality of banking services, and satisfaction using factor analysis to ensure that the five indicators proposed for each construct are eligible to be analyzed using the Structural Equation Model (SEM) method. The study found that the construction of deposit products and service quality have a positive impact on depositors' satisfaction with a dominant impact on deposit products. Banking service quality delivered by RDBs can attract deposit consumers as they have already convenience with the products and service quality Keywords:Product Quality, Product Features, Service Quality, Depositors’ Satisfaction Peran Produk dan Kualitas Layanan dalam Daya Saing: Studi Kasus tentang Kepuasan Nasabah AbstrakPenelitian ini mengumpulkan data 100 simpanan pada tiga Bank Pembangunan Daerah. Data yang terkumpul kemudian digunakan untuk menganalisis konstruk produk tabungan, kualitas layanan perbankan, dan kepuasan menggunakan analisis faktor untuk memastikan bahwa kelima indikator yang diajukan untuk setiap konstruk memenuhi syarat untuk dianalisis menggunakan metode Structural Equation Model (SEM). Temuan menunjukkan bahwa, kecuali daya tanggap untuk konstruk kualitas layanan perbankan, semua variabel terukur dikatakan dapat mendefinisikan konstruknya. Lebih lanjut, konstruksi produk simpanan dan kualitas layanan berpengaruh positif terhadap kepuasan nasabah dengan dampak dominan terhadap produk simpanan. Artinya, fitur-fitur yang ditawarkan dan kualitas layanan perbankan yang diberikan oleh BPD dapat menarik minat nasabah simpanan karena sudah memiliki kemudahan dengan kualitas produk dan layanan.. Kata kunci: Kualitas produk, fitur produk, kualitas pelayanan, kepuasan nasabah.
Nowa ewangelizacja w kontekście wybranych zagadnień współczesnej kultury i komunikacji
Authors:   The Pontifical University of John Paul II in Krakow, Poland, Parszywka Adam
Published: December 2022

The new evangelization is the enthusiasm to live the faith passed on to communities that are still unaware of the Good News. Contemporary evangelizers, for whom Saint Paul is a model, should undertake activities in the area of “modern areopagos” – large urban agglomerations, and proclaim the Gospel also through the means of communication used today by the broadly understood culture. There are two main tasks facing the new evangelization: updating the forms of communication to the contemporary language of communication, as well as shaping culture in accordance with the Gospel, creating a Christian culture.
СУЧАСНИЙ ПОГЛЯД НА КОРЕКЦІЮ ДЕФІЦИТУ СЕЛЕНУ З ПОЗИЦІЇ ДОКАЗОВОЇ МЕДИЦИНИ (огляд літератури та дані власних досліджень)
Authors: Турчина Світлана , Сотнікова-Мелешкіна Жанна , Калмикова Юлія , Калмиков Сергій , Міхановська Наталія
Published: December 2022

Мета. Вивчити сучасні дані про роль селену (Se) в організмі людини, методи оцінки його вмісту, шляхи профілактики та корекції селенодефіциту з позиції доказової медицини.

Резюме Подані в огляді дані вказують на важливість ессенціального мікроелемента Se для забезпечення нормальної життєдіяльності людини. Відображено результати дослідження забезпечення населення селеном у різних регіонах та сучасні підходи до об'єктивної оцінки його вмісту в організмі. Наведено еталонні норми споживання селену, засновані на визначенні концентрації селенопротеїну (SePP), як найбільш об'єктивного маркера для визначення оптимального запасу Se. Доведено, що зниження або, навпаки, збільшення надходження дієтичного Se може негативно впливати на стан здоров'я, приводити до розвитку хронічних соматичних та психічних захворювань, зокрема депресії. Наведено власні дані про негативний вплив дефіциту Se на формування та несприятливий перебіг дифузного нетоксичного зобу (ДНЗ) у дітей та підлітків, які проживають в умовах легкого йододефіциту.

Розглянуто шляхи профілактики та корекції селенодефіциту з позиції доказової медицини та необхідність проведення індивідуальної профілактики та корекції дефіциту Se шляхом призначення дієтичного селену, особливо у разі відсутності державних програм, що включають збагачення ґрунтів, кормів та продуктів харчування сполуками Se. Науково обґрунтовано доцільність включення препаратів Se до комплексної терапії хворих з несприятливим перебігом ДНЗ, що позитивно впливало на стан тиреоїдної системи, сомато-статевий розвиток, стан соматичного та психічного здоров'я, когнітивні функції та якість життя підлітків.

Представлено результати клінічних та експериментальних досліджень, які свідчать, що включення до терапії препаратів Se у вікових дозах дозволяє  запобігти формування метаболічного синдрому та ожиріння, порушень вуглеводного обміну та тиреопатій, підвищити ефективність лікування пацієнтів з різними соматичними та психічними захворюваннями, збільшити фізичну витривалість під час інтенсивних навантажень у спортсменів.
Affective Transformation
Authors: Dasgupta Dr. Arnab
Published: December 2022

Kyoto Animation can rightly be called one of the leading studios of Japanese animation, and its works have been at the forefront of anime production in terms of both techniques and aesthetics. This is why it has been subjected to academic scrutiny by several notable anime scholars. However, no significant studies have been conducted on the works of Kyoto Animation from the perspective of the studio as a whole, or identified consistent themes and patterns flowing throughout them. This paper aims to rectify that gap by studying four works by the most prolific directors of Kyoto Animation (the Haruhi Suzumiya series (2006-2010), Beyond the Boundary (2013-15), A Silent Voice (2016) and Miss Kobayashi’s Maid Dragon (2017)) from the perspective of the Japanese Buddhist conception of tariki (Other-power) in order to tease out the central theme that lies at the heart of the studio’s work, and argues that Other-power (redefined as affective transformation) and the presence of a community of peers to nurture it offers powerful interpretive frameworks through which to understand these, and other, works by the studio.
Nation Building and the Role of Leadership
Authors: Cserkits Michael
Published: December 2022

In this paper, I will deal with the isekai anime ‘Tensei shitara slime datta ken‘ (eng.: That Time I got reincarnated as a slime) and will examine its potential power and messages in a new shed light. As the main argument of this paper will deal with the main character and his ‘semi-diplomatic’ attempts to build a nation out of the blue, I will argue that in critically analyzing the strategic ends, ways and means used by the main character can give insight into to mindset of an archetypical understanding of how and under which circumstances leadership and social interaction between human beings is presented in a Japanese context. For a better understanding of this – unfortunate – less researched field, I will present the current state of research regarding isekai animes. After a synopsis of the series of interests, specific aspects and actions of the main character will be highlighted to contribute to a better and critical understanding of the presumed unintended message that ‘Tensei shitara slime datta ken‘ is sending.
30 Years Later, Re-Examining the “Pretty Soldier”
Authors: Yatron Cassandra
Published: December 2022

December of 2021 marks the 30th anniversary of Naoko Takeuchi’s Bishojo Senshi Sailor Moon (Pretty Soldier Sailor Moon) manga (1991-1997), and March of 2022 will mark the 30th anniversary of Toei Animation’s Bishojo Senshi Sailor Moon anime (1992-1997). The series follows Sailor Moon as she defends Tokyo and the galaxy against alien enemies. While there seems to be controversy over whether Sailor Moon can be read as a feminist text, Sailor Moon still maintains its status as a feminist and queer magical girl series. Although there has been some scholarship on the magical girl genre and gender roles in manga and anime, there has not been much written about Sailor Moon specifically. As an influential series that is still relevant in pop culture, further analysis of this text is necessary to identify its feminist and queer nature. Despite being three decades old, Sailor Moon still maintains its status as a feminist and queer magical girl series. My argument is that on the surface, the Sailor Moon franchise appears to be a heteronormative and an (arguably) antifeminist series with traditional heterosexual relationships and gender stereotypes, but upon closer examination, the manga and anime series subvert patriarchal and gender stereotypes in both obvious and discrete ways.
Telehealth Care for Mothers and Infants to Improve the Continuum of Care: Protocol for a Quasi-Experimental Study
Authors: Kikuchi Kimiyo , Islam Rafiqul , Sato Yoko , Nishikitani Mariko , Izukura Rieko , Jahan Nusrat , Yokota Fumihiko , Ikeda Subaru , Sultana Nazneen , Nessa Meherun , Nasir Morshed , Ahmed Ashir , Kato Kiyoko , Morokuma Seiichi , Nakashima Naoki
Published: December 2022

Background

Ensuring an appropriate continuum of care in maternal, newborn, and child health, as well as providing nutrition care, is challenging in remote areas. To make care accessible for mothers and infants, we developed a telehealth care system called Portable Health Clinic for Maternal, Newborn, and Child Health.

Objective

Our study will examine the telehealth care system’s effectiveness in improving women’s and infants’ care uptake and detecting their health problems.

Methods

A quasi-experimental study will be conducted in rural Bangladesh. Villages will be allocated to the intervention and control areas. Pregnant women (≥16 gestational weeks) will participate together with their infants and will be followed up 1 year after delivery or birth. The intervention will include regular health checkups via the Portable Health Clinic telehealth care system, which is equipped with a series of sensors and an information system that can triage participants’ health levels based on the results of their checkups. Women and infants will receive care 4 times during the antenatal period, thrice during the postnatal period, and twice during the motherhood and childhood periods. The outcomes will be participants’ health checkup coverage, gestational and neonatal complication rates, complementary feeding rates, and health-seeking behaviors. We will use a multilevel logistic regression and a generalized estimating equation to evaluate the intervention’s effectiveness.

Results

Recruitment began in June 2020. As of June 2022, we have consented 295 mothers in the study. Data collection is expected to conclude in June 2024.

Conclusions

Our new trial will show the effectiveness and extent of using a telehealth care system to ensure an appropriate continuum of care in maternal, newborn, and child health (from the antenatal period to the motherhood and childhood periods) and improve women’s and infants’ health status.

Trial Registration

ISRCTN Registry ISRCTN44966621; https://www.isrctn.com/ISRCTN44966621

International Registered Report Identifier (IRRID)

DERR1-10.2196/41586
Development and Application of the WeChat Public Account “I Love Parasitology” in the Teaching of Human Parasitology (Preprint)
Authors: Zhu Honggang , Deng Weiwen , Guan Fei , Lei Jiahui
Published: December 2022

BACKGROUND

Digital approaches have been demonstrated to transform medical education to achieve higher levels of knowledge and skills through competency-based education. The quick and instant communication function of WeChat public accounts enables teachers and students notifications and interactive feedback anytime and anywhere, which will facilitate a student-centered teaching mode.

OBJECTIVE

To better construct teaching resources and improve teaching quality of parasitology, our team set up a WeChat public account “I love Parasitology”, which was used as an auxiliary communication platform during our routine teaching.

METHODS

The data sources were mainly from original pictures and multimedia materials of different parasites collected and produced by our team, as well as related materials collected from traditional publications and new media. All materials were reclassified and packaged according to the teaching schedule. Furthermore, with the instant interactive platform, course schedules and corresponding teaching contents were sent by push notifications, case-based learning was carried out, and two-way communication between students and teachers was achieved. Teaching effectiveness was assessed using a self-evaluation questionnaire.

RESULTS

A WeChat public account suitable for our daily teaching of parasitology was established. The second recursion and implementation of the learning resources allowed students to conduct in-depth reading and get unrestricted access to high-quality resources through the public account. In addition, all contents were in digital forms and made the original resources reborn, which would make up for our current and future shortage of physical teaching specimens. Moreover, the results from the questionnaire indicated that all these actions promoted students to master theoretical knowledge, improved their abilities of case analysis and of communication, and increased their knowledge of academic progress.

CONCLUSIONS

Our WeChat public account can provide excellent learning materials for students and is a good supplement to the routine education of human parasitology. With the advances in the information age, new media as a communication tool will accelerate further advancement of medical teaching, thus innovating medical education methods.
Особливості лакунарного інсульту варолієвого моста: результати госпітального проспективного когортного дослідження
Authors: Prokopiv M.M. , Yevtushenko S.K. , Fartushna O.Ye.
Published: December 2022

Вступ. Нових даних про проспективні госпітальні когортні дослідження, у яких проаналізовано клінічні та візуалізаційні ознаки лакунарного інфаркту моста, майже не опубліковано. Мета: визначити клінічні та нейровізуалізаційні особливості лакунарного інфаркту варолієвого моста на ранній стадії в госпітальному проспективному когортному дослідженні. Матеріали та методи. Ми проспективно відібрали 120 пацієнтів, госпіталізованих до неврологічного центру із гострим інсультом у вертебробазилярному басейні, підтвердженим магнітно-резонансною томографією. Особи з інсультом моста були включені в дослідження протягом 6 годин від розвитку симптомів інсульту. Усім пацієнтам проведено комплексне неврологічне, клінічне, лабораторне, ультразвукове та візуалізаційне обстеження. Результати. Із 120 пацієнтів віком від 28 до 89 років у 15 (12,5 %) був діагностований лакунарний інфаркт моста. Проведено комплексне клінічне, неврологічне, лабораторне та інструментальне дослідження особливостей лакунарного інфаркту моста. Висновки. Визначено, проаналізовано та описано специфічні клінічні та візуалізаційні ознаки раннього лакунарного інфаркту моста.
Вплив фармакологічної кардіоверсії аміодароном на неврологічні симптоми та когнітивні функції пацієнтів із пароксизмом фібриляції передсердь
Authors: Stadnik S.M.
Published: December 2022

Метою нашої роботи було оцінити вплив успішної фармакологічної кардіоверсії аміодароном на неврологічну симптоматику та когнітивні функції в пацієнтів із пароксизмом фібриляції передсердь. Матеріали та методи. Сто шістнадцять хворих із когнітивними розладами на фоні пароксизму фібриляції передсердь були розподілені на 2 групи залежно від призначеної терапії: група 1 (контроль ритму) — 87 осіб, яким для відновлення синусового ритму проводили фармакологічну кардіоверсію аміодароном; група 2 (контроль частоти серцевих скорочень) — 29 пацієнтів, яким відновлення синусового ритму не виконували через наявність протипоказань. Результати. У хворих із відновленим синусовим ритмом спостерігалося більш виражене регресування неврологічної симптоматики порівняно з групою контролю ритму. На фоні відновлення синусового ритму відзначено значне покращення всіх когнітивних функцій: пам’яті, уваги, швидкості мовлення, зорово-просторового та симультаного гнозису, мовленнєвої активності, а також емоційного статусу. Поліпшення показників центральної та церебральної гемодинаміки визначалося насамперед за відновленням ритму та зниженням частоти серцевих скорочень. Позитивна клінічна динаміка в процесі відновлення синусового ритму поєднувалася зі статистично достовірним зниженням умісту прозапальних цитокінів, що свідчило про зменшення активності імунного запалення. Висновки. Відновлення синусового ритму покращує неврологічну симптоматику, сприяє зниженню вираженості когнітивних та афективних розладів у хворих із пароксизмом фібриляції передсердь за рахунок зменшення гіперсимпатикотонії, покращення систоло-діастолічних характеристик лівого шлуночка, скоротливої функції міокарда лівого шлуночка, центральної гемодинаміки, функціонального стану мозкового кровотоку, зниження активності імунного запалення.
Anti-osteoporotic treatment and COVID-19 risk: is there an association?
Authors: Grygorieva N.V. , Bystrytska M.A. , Zaverukha N.V. , Musiienko A.S.
Published: December 2022

Introduction. Despite the recent ASBMR, AACE, Endocrine Society, ECTS&NOF guidelines for osteoporosis management in the era of COVID-19 the impact of antiosteoporotic drugs on disease risk and severity is insufficiently studied. The purpose of this study was to assess the COVID-19 risk for the patients receiving the parenteral bisphosphonate or Denosumab treatment, and the severity of its course in patients with systemic osteoporosis. Materials and methods. We performed the phone survey and studied the results of 195 patients (92 % women; mean age – 62.7±10.8 years) with systemic osteoporosis depending on the current use of parenteral antiresorptive drugs (Zoledronic, Ibandronic acids, or Denosumab, n = 125) and compared the results with data of the patients with osteoporosis who did not use any anti-osteoporotic drugs previously (n = 70). Results. The group of patients with COVID-19 included 32.9 % of patients who did not receive previously any anti-osteoporotic treatment and 33.3 % of osteoporotic patients treated with parenteral antiresorptive drugs. The share of the patients taking the Zoledronic acid who fell ill with COVID-19 was 29.2 %, the share of those taking the Ibandronic acid was 34.4%, and the share of those taking Denosumab was 42.9 %. We did not reveal any significant differences in the COVID-19 frequency and severity depending on the presence and type of parenteral anti-osteoporotic therapy. Additionally, there were no differences depending on the patients' age, gender, obesity, and other osteoporosis risk factors. The risk of COVID-19 in the patients with systemic osteoporosis did not differ depending on antiresorptive drug use, amounting (odds ratio (OR) 95 % CI) 1.1 (0.6-2.0), or on the use of the definite anti-osteoporotic drug (for the Zoledronic acid – 0.9 (0.4-2.0), the Ibandronic acid – 1.1 (0.5-2.3), and for the Denosumab – 1.6 (0.5-5.2). Conclusions. Parenteral anti-osteoporotic drugs (Zoledronic acid, Ibandronic acid, or Denosumab) do not have any influence on COVID-19 frequency and severity and can be recommended for the continuation of the treatment of patients with osteoporosis.
Quality of life in patients with ankylosing spondylitis with anemic syndrome assessed according to the ASQoL questionnaire, the relationship with the course of the disease
Authors: Shevchuk S.V. , Zviahina O.V. , Zviahin О.S. , Bezsmertnyi Y.O. , Segeda I.S.
Published: December 2022

Introduction. Anemia, as a frequent comorbid pathology, increases the severity of the course, reduces the quality of life (QoL), and worsens the prognosis in patients with ankylosing spondylitis (AS). However, studies examining the impact of anemia on the course of the disease and QoL assessed using the ASQoL questionnaire are currently insufficient. The purpose was to analyze the QoL indices according to the ASQoL questionnaire in AS patients with anemia and to evaluate its dependence on gender, as well as the form and course of the disease. Materials and methods. 118 patients with AS and 26 practically healthy subjects, representative of age and gender, had been examined. QoL index was assessed using the ASQoL questionnaire. Results. QoL index in AS patients according to the ASQoL questionnaire was 8.96±0.41 points. In AS patients with anemic syndrome, the QoL parameter was 11.85 ± 0.74 points, QoL index in AS patients without anemia was 7.88±0.44 points. Patients with a peripheral form of AS and anemia have worse QoL index according to ASQoL scores (12.13 ± 0.94), compared to the subjects with a central form of AS and anemia (10.42 ± 1.21). Also, the worst indices of QoL were established in patients with anemia of chronic disease (ACD) (16.27 ± 0,44) and ACD with iron deficiency (11.50 ± 0.92). In the subjects with iron deficiency anemia (IDA), the indices of QoL did not significantly differ from parameters of the patients without anemia (7.16 ± 0.52). Disease activity and the presence of anemic syndrome have a reliable (p<0.05) direct correlation (IL-6: r = 0.62; CRP: r = 0.68; BASDAI: r=0.5; ASDAS: r = 0.25) with deterioration of QoL index according to ASQoL. Conclusions. Аnemia is a frequent comorbid pathology in patients with AS and worsens the QoL indices of the patients. The degree and pathogenetic type of anemia (in particular, ACD) is closely correlated with the lower QoL index of patients with AS.
The impact of gait on hip joint formation in patients with cerebral palsy
Authors: Yatsuliak M. , Martsyniak S. , Filipchuk V.
Published: December 2022

Introduction. The influence of the gait on the hip joint formation in patients with infantile cerebral palsy (CP) is an actual object of scientific research. The purpose of the research was to study the correlations between walking and clinical and roentgenometric parameters of the hip joint in the patients with CP. Materials and methods. There were examined 39 patients with CP and pathology of the hip joints (70 joints), who had been treated at the National Research Institute of Traumatology and Orthopedics for the period from 2018 to 2022. The patients had been divided into 2 groups depending on the ability to walk. We had performed a clinical and roentgenogramometric examination of the hip joints in positioning according to our own method and the standard anterior-posterior radiological position. All patients underwent a clinical assessment of femoral torsion using the Ruwe method. To assess the relationships between the studied indices Spearman's correlation analysis was performed. Results. The positive influence of gait on the hip joint formation had been revealed. The average values of the hip clinical and roentgenometric parameters in patients with CP who do not walk were significantly higher compared to those of subjects who walk. Correlation analysis revealed the relationship between walking and the studied parameters of the hip joint (cervical-diaphyseal angle, femoral torsion, acetabular angle, Sharp angle, Reimers index, the center edge angle of Wiberg) in both settings, as well as walking and other factors (age, level lesion, GMFCS scale (II-IV level), congenital dysplasia of the hip joints in the history). At the same time, there was no found any dependence between gait and adductor myotomy in the history. Conclusions. A significant influence of the gait on the following parameters of the hip joint was established: the true cervical-diaphyseal angle (p=0.00001) in positioning according to our own method, femoral torsion (p = 0.01), acetabular angle (standard setting) (p=0.00001), Sharpe angle (standard setting) (p = 0.018), Reimers index (standard setting) (p = 0.00007), center edge angle of Wiberg (standard setting) (p = 0.001) and lack of statistical significance of the influence of the adductor myotomy factor in history (p=0.11) on the walking function.
Peculiarities of the structural and functional state of bone tissue in children during the second growth spurt
Authors: Frolova T.V. , Osman N.S. , Stenkova N.F. , Tereshchenkova I.I. , Siniaieva I.R. , Senatorova A.V. , Amash A.H.
Published: December 2022

Background. Bone health is relevant for patients of all age groups. Special attention is paid to childhood and adolescence, since it is during this period that bone mass is actively accumulated, which depends on the structural and functional state of the bone tissue of an adult. The purpose of this study was to determine the features of the structural and functional state of bone tissue in children during the second growth spurt based on the analysis of markers of bone modeling, the level of 25(OH)D and the indicators of ultrasound densitometry and DXA. Materials and methods. 205 children aged 9–17 years were examined. They divided into three groups depending on the presence and intensity of growth spurts. Examination included: general clinical examination with an assessment of the levels of physical and sexual development, determine of the levels of 25(OH)D, glycosaminoglycans, chondroitin sulfates and alkaline phosphatase, ultrasound densitometry and DXA. Results. 83.9 % of children had vitamin D deficiency, 16.1 % of children had insufficiency. A decrease in BMD according to UD data was diagnosed in 48.0 % (n = 24) of children with growth spurt, in 60.87 % (n = 28) of children with intense growth spurt, and in 39.45% (n = 43) of children without growth spurt. According to DXA data, BMD reduction was confirmed in 56.25 % (n=18) of 32 examined children: children with growth spurt — 38.9 % (n=7), children with intense growth spurt— 50.0% (n = 9), children without growth spurt — 11.1 % (n = 2). The level of chondroitin sulfates in children with growth spurt and intense growth spurt is significantly higher than in children without growth spurt, which indicates the instability of metabolic processes. At the same time, the level of total glycosaminoglycans is significantly lower in the group of children with growth spurt and intense growth spurt than in the group of children without growth spurt, which indicates the intensity of metabolic processes in children of these groups. Conclusions. 100 % of children had insufficiency and deficiency of vitamin D. A decrease in BMD is more often diagnosed in children during an intense growth spurt and does not have a reliable relationship with the level of vitamin D, in contrast to children without a growth spurt. Children with growth spurts and intense growth spurts had an imbalance in the level of chondroitin sulfates and glycosaminoglycans, which indicates the instability and activity of bone tissue growth processes.
“A THOUSAND MILES” AND “A THOUSAND TASKS”: CHINA’S DIPLOMATIZATION OF MULTIFACETED RUSSIA-UKRAINE CONFLICT AND GLOBAL SECURITY
Authors: Stefanovic-Stambuk Jelica , Popovic Slobodan
Published: December 2022

The People’s Republic of China’s (PRC, China) unflinching stance throughout the ongoing Russian-Ukraine conflict has raised many eyebrows and provoked diverse reactions. The lingering question in different quarters is why China acts as it does and with what intentions. Once again, one troubling international turmoil was laid at the Chinese doorstep, almost turning into “China’s dilemma”. The starting assumption is that PRC’s conduct shows an unswerving strategic orientation toward “building a community with a shared future for mankind” (建设人类命运共同体) through persistent diplomatization. Diplomatization is a distinct process of containing grave security problems by making them a matter of diplomacy. Current analysis falsifies this starting proposition through conceptual inquiry into key actions and documents in China’s diplomatic and political relations with Ukraine in the period from the establishment of the strategic partnership in 2011 up to the head-start of diplomatization of the convoluted Russia-Ukraine conflict by the Global Security Initiative in April 2022. A strong diplomatization pattern is found, showing that China’s stand regarding the Russia-Ukraine conflict is a case of diplomatized security concerns as a trigger for the head-started diplomatization of global security. China consistently pursued conceptualization and persuasion to dispel insecurities and contain warfare and ensuing global disturbances through conversation and deliberation focused on boosting major joint leaps for transforming obsolete modes of governance structures to becoming aligned to the manifest direction of epochal change. Furthermore, China’s global security outlook is firmly anchored in the national security concept.
THE IMPACT OF THE WAR IN UKRAINE ON THE WESTERN BALKANS
Authors: Kolarski Ljiljana
Published: December 2022

The war in Ukraine represents a turning point in international relations that significantly affects the common foreign and security policy of the European Union. By taking place on European soil and mainly between Russia and Ukraine, it really indirectly affects several countries united in two important entities, the European Union and NATO. In this paper, we will deal with the analysis of the impact of the war in Ukraine on the countries of the Western Balkans, which are in a significant geopolitical position and have developed relations with Russia in the fields of foreign policy, security, and energy. The work aims to contribute to the understanding of the implications that are happening and that may arise in the domain of internal and foreign policy of the Western Balkan countries, and especially regional relations, as a consequence of the war in Ukraine. In the first part of the paper, attention is paid to a theoretical explanation of war and realism in international relations which could be implied to this war. Furthermore, a brief overview of the political events that led to the Russian invasion of Ukraine will be presented in order to understand the next chapter, which is dedicated to considering the response of each Western Balkan state to the beginning of the war and the events that came as a result of it.
De la détente à l’entente (1966-1969), des relations franco-yougoslaves restaurées ?
Authors: Markovic Sacha
Published: December 2022

L’espoir de tout rapprochement significatif avec Moscou s’étant progressivement éteint et les démocraties populaires n’ayant pas vraiment donné suite aux appels du pied de Paris, la diplomatie française a jeté son dévolu sur Belgrade. Ce mariage de raison, alors que son cœur l’entraînait beaucoup plus vers Varsovie, Bucarest ou Prague, offre au Général le cadre confortable d’une concordance de vue objective entre la France et la Yougoslavie sur de nombreux dossiers internationaux majeurs. La relation franco-yougoslave devient ainsi le grand bénéficiaire, un peu fortuitement, des déconvenues françaises à l’Est, et notamment de l’invasion de la Tchécoslovaquie, de la sensibilité très peu gaullienne de Gomulka et des aspirations très solitaires de Ceaucescu. Josip Broz Tito retrouve ainsi grâce aux yeux du héros de la Résistance française, parce que la Fédération yougoslave est le seul pays socialiste avec lequel la France peut finalement réaliser son rêve de détente-entente-coopération. La diplomatie yougoslave voit Belgrade se muer en partenaire privilégié contre toute attente mais en dernière instance l’ambition ultime de Charles de Gaulle demeure la réconciliation de toutes les nations européennes, de l’Atlantique à l’Oural.
Territorialisation et spatialisation du développement économique à la périphérie de l’Union européenne: les macro-régions dans les Balkans occidentaux
Authors: Vukadinovic Nebojsa
Published: December 2022

Depuis 1997, l’UE favorise la coopération régionale dans les Balkans. Celle-ci a pris depuis différentes formes: coopération régionale, zone de libre-échange, bons rapports de voisinages. Depuis quelques années, l’UE développe le concept de macro-régions qui permets aux Etats balkaniques qui souhaitent entrer dans l’UE de développer des projets communs entre eux mais aussi avec les pays déjà membres de l’Union européenne. Deux macro-régions ont ainsi vu le jour: la macro-région adriatique-ionienne et la macro-région du Danube. La France soutient le concept de macro-région dans les Balkans occidentaux. Cet article met également en évidence ce que la stratégie de la macro-région EUSAIR et la stratégie du Danube peuvent offrir au processus d’élargissement. La Serbie participe aux deux macro-régions. Quels sont les moyens mis en œuvre et les objectifs permettent-ils le développement économique ? Les macro-régions permettent-elles vraiment les échanges entre les Etats de la région et l’intégration des pays des Balkans à l’UE?
Plan estratégico de desarrollo para una comunidad totonaca en México
Authors: López Santiago Marco Andrés , García Vázquez Rafael , Valdivia Alcalá Ramón , Sánchez Toledano Blanca Isabel
Published: December 2022

En México existe un problema de inseguridad alimentaria que se acentúa con mayor frecuencia en comunidades rurales. El objetivo principal de este artículo fue definir un plan estratégico de desarrollo local a través de estrategias de reproducción propuestas por los hogares de una comunidad indígena totonaca para satisfacer sus necesidades nutricionales en relación con el uso de los recursos naturales que poseen. Se aplicó un cuestionario a 328 viviendas en el municipio Filomeno Mata, Veracruz, México. Se formularon las estrategias de reproducción campesina orientadas a la autosuficiencia alimentaria y se utilizó un análisis de conglomerados para determinar los factores asociados. Los resultados mostraron un plan estratégico de desarrollo local con once estrategias que buscan incidir en la implementación de alimentos nativos en la comunidad. A partir del análisis de las variables socioeconómicas de los hogares, se definieron cuatro grupos y se determinó la estrategia con mayor potencial de éxito en cada uno. Las estrategias presentadas están vinculadas a procesos donde las prácticas sociales, económicas y culturales están estrechamente relacionadas. Éstos conforman una propuesta para la satisfacción de las necesidades alimentarias de los hogares como apoyo a la volatilidad de los precios de los alimentos.
Significant Caries (SiC) Index and Distribution of Regional Origins for Members of Formed Police Unit (FPU) XI
Authors: Yulita Ita , Purnama Tedi , Hidayah Nurul
Published: December 2022

Indonesia's geographical conditions are very diverse. Oral disease which is the most common global health problem is caries. An indicator of caries experience which includes decay, missing, filled criteria is DMF, the easiest and most frequently used method for epidemiological surveys of dental caries. To identify the subset of the population with high and very high DMF-T scores and to find individuals who are still susceptible to caries, the Significant Caries (SiC) index is used as a complement to the average DMF-T value. This study aims to determine the description of the Significant Caries (SiC) index and the distribution of regional origins of members of the Formed Police Unit (FPU) in LKOK Pusdokkes Polri Jakarta by the year 2020. This research is descriptive study with a total sampling method of selecting samples. A The DMF-T score was 1157 with a mean DMF-T of 6.4 (high criteria), and SiC index of 11.4 (very high criteria). Respondents from the Western Region of Indonesia had a DMF-T score of 465 and SiC index of 11.34 (very high criteria). The DMF-T score for respondents from Central Region of Indonesia was 155 and SiC index 11.9 (very high criteria). Respondents from Eastern Region of Indonesia had DMF-T score of 76 and SiC index 10.85 with (very high criteria). It can be concluded that respondents have DMF-T scores in the high criteria and SiC index with very high criteria. Based on the regions of origin of the respondents, SiC score index in all three regions are of origin is included in the very high criteria with respondents from the Central Region of Indonesia having the highest SiC index compared to the other 2 regions.
Keywords: Significant Caries (SiC) Index, Regions of Origin of FPU XI Member