bluuebunny/crossref_metadata_2025 huggingface dataset:
Sundhed.dk and MyHealth During the Corona Storm
Authors: Elbæk Petersen Morten
Published: August 2022

Background

The Danish eHealth portal, sundhed.dk, pioneers open access to medical records since 2003 and is, in this regard, unique worldwide. As part of the Danish health care sector, sundhed.dk supports transparency and patient empowerment and provides health professionals with the possibility to access patient health data outside of local systems and across sectors and boundaries. Sundhed.dk and the MyHealth app have played a crucial role during the COVID-19 pandemic in Denmark, not least due to the development of the corona passport.

Objective

The overall purpose during the COVID-19 pandemic has been to assist the health authorities handling the pandemic and to support patient empowerment. Sundhed.dk provided new digital services to support monitoring the spread of the virus and telemedicine solutions to support the Danish citizens both during isolation and as the society was gradually reopening.

Methods

By exploiting sundhed.dk’s known and widespread position in the society and the already existing digital building blocks, sundhed.dk and MyHealth managed to provide fast and easy access to COVID-19 laboratory responses and, on top of that, to develop the corona passport, which was the result of accelerated IT development and fast scaling of the required server with the users.

Results

The many digital services accessible through sundhed.dk or MyHealth made it possible for Danish citizens to continue to see their doctor or physiotherapist during lockdown. Moreover, the corona passport made the safe and efficient reopening of Denmark possible.

Conclusions

The story of sundhed.dk during the COVID-19 pandemic is a story of success, a result of its close interdisciplinary and cross-sectoral cooperation with Danish health authorities and private IT vendors. It illustrates what can be achieved when there is a unified blueprint and overall purpose to overcome barriers in order to ensure development and progress for both the individual and the society. This has also drawn global attention, as reflected in a report by the World Health Organization.
Putting the Stars within Reach Using NASA 3D Data-Based Models
Authors: Arcand Kimberly K.
Published: August 2022

This study investigated the quantifiable effects of data-based 3D models and prints on spatial reasoning skills and interest in science, technology, engineering, and mathematics (STEM) fields, for n = 100 youths aged 9-12 (99 female and 1 non-binary), primarily from traditionally underrepresented groups in STEM. In a pre-post design, participants engaged in workshops using data-based astrophysical 3D models delivered via computer-based interactions, virtual reality, and 3D prints. Multivariate ANOVAs yielded significantly increased STEM interest but were not significant for increasing spatial ability. The results are discussed in terms of the need to extend exposure and science communications to STEM activities to female youths that are younger than middle school aged.
Confinement and Activities
Authors: Mous Anony
Published: August 2022

The key question is that do the new activities mean you are not so bored which could cure the feelings of being locked up? They can distract you with keeping busy but it doesn’t change that the hospital environment feels like living in an institution. Even with the new surroundings it still has the feel of a hospital. You can put up with this for a while but not forever and after a while feelings of being in hospital will outweigh the activities which may distract you.
Sandino, Guiteras y las variantes del nacionalismo revolucionario
Authors: Rojas Rafael
Published: August 2022

el objetivo de este artículo es analizar los movimientos políticos encabezados por el nicaragüense César Augusto Sandino y el cubano Antonio Guiteras en sus respectivos países, pero en el contexto del nacionalismo revolucionario y de la lucha antimperialista de la región en la tercera década del siglo xx. Basado en un análisis comparativo y sustentado con fuentes primarias y secundarias, el artículo revela y demuestra las variantes del nacionalismo revolucionario expresado a partir de las condiciones políticas e ideológicas específicas de Nicaragua y Cuba de esos años, destacando, como principal hallazgo, la identificación y descripción de nombres, grupos, ideas, y organizaciones políticas en el proceso histórico que caracterizó a cada nación.Palabras clave: Sandino; Guiteras; Nacionalismo revolucionario; Socialismo; Antimperialismo; América Latina.
Autonomía de los pueblos indígenas latinoamericanos Estudios de caso comparativo entre Chilón (México) y Charagua (Bolivia)
Authors: Sánchez Martínez Luvia Magdalena , Parra Vázquez Manuel Roberto , Zamora Lomelí Carla Beatriz
Published: August 2022

en 2017 se puso en funcionamiento el Gobierno Autónomo Indígena Originario Campesino en Charagua, ubicado en la región guaraní del Chaco boliviano. En ese mismo año, tzeltales de Chilón en el sur de México iniciaban su proceso legal por el reconocimiento del derecho a la libre determinación. Este artículo analiza y compara dos proyectos de autonomía indígena: una propuesta en construcción, el Gobierno Comunitario en Chilón; y otra en funcionamiento, la Autonomía Indígena Originario Campesino Charagua. A partir de un análisis desde el enfoque de la Teoría de Movilización de Recursos, se identificaron similitudes en las estrategias, los recursos y los actores que han intervenido en ambas experiencias. Se concluye que existen patrones de comportamiento en la acción colectiva de ambas experiencias. Sin embargo, la estructura de las oportunidades políticas determinará el éxito de los movimientos autonómicos.
Flora de Guerrero N° 90. Muhlenbergia
Authors:   Facultad de Ciencias, Vigosa Mercado José Luis , Fonseca Rosa María ,   Facultad de Ciencias
Published: August 2022

Género con aproximadamente 186 especies, la mayoría de ellas distribuidas en el sur de Estados Unidos de América y norte de México, algunas en Asia. Muhlenbergia es el género de Poaceae más diverso en México.
Dos especies nuevas del género Platydecticus (Orthoptera: Tettigoniidae) para el área Altoandina Austral en Chile central
Authors: Vera-Sánchez Alejandro
Published: August 2022

Se describen 2 especies nuevas del género Platydecticus, P. elguetai n. sp. y P. atelcura n. sp. Ambas han sido descritas con ejemplares machos, hembras y huevos. Estas 2 especies se distribuyen en Chile central sobre los 2,300 m snm. Platydecticus elguetai n. sp. y P. atelcura n. sp. son morfológicamente similares a P. angustifrons en la forma del fastigio del vertex y los cercos. Los caracteres diagnósticos más relevantes en las 2 especies nuevas se presentan en la morfología de los pseudocercos, la placa subgenital masculina, el titilador, la denticulación del ovipositor y la distribución de las micrópilas.
Áreas de endemismo de Ecuador: un análisis a partir de datos de distribución de especies de plantas, animales y hongos
Authors: Liria Jonathan
Published: August 2022

Se analizaron 407,570 datos de distribución de 10,390 especies de plantas, animales y hongos de Ecuador, obtenidos en 4 repositorios de biodiversidad (GBIF, NHM, SpeciesLink y BNDB) como soporte en la delimitación de áreas para conservación y estudios biogeográficos. Las especies fueron asignadas a 1,773 categorías supraespecíficas para evaluar el apoyo de ciertos grupos en las áreas de endemismo (AE). Las identificación de AE se realizaron en VNDM/NDM empleando 2 tamaños de cuadrículas (0.75º y 1º latitud-longitud) y los resultados se resumieron mediante consensos. Los análisis de 0.75º y 1º resultaron en 272 y 88 AE, respectivamente, resumidas en 94 y 28 áreas consenso. La mayoría de AE consenso estuvieron sustentadas, principalmente, por especies de Tracheophyta y Chordata, y solo un área en Galápagos por especies de Chordata seguido en menor proporción por Tracheophyta, Arthropoda y Mollusca. Cuatro áreas mostraron soporte de grupos supraespecíficos endémicos principalmente géneros. Algunas especies se incluyeron en la lista de la UICN, mayoritariamente en las categorías de preocupación menor y vulnerable. Los resultados de AE en Ecuador evidencian la importancia de las bases de datos abiertas sobre biodiversidad y servirán de base para estudios sobre conservación y definiciones de categorías en las regionalizaciones biogeográficas.
PROFUNDIDAD DE DISCO DE SECCHI Y SU RELACIÓN CON LA TURBIDEZ Y CLOROFILA “A” EN EL EMBALSE SAN JACINTO, TARIJA, BOLIVIA
Authors: Fernandez Deimar , Muñoz Luis , Coronel Esperanza Flor
Published: August 2022

La profundidad de observación del disco de Secchi es un indicador de la calidad del agua de los embalses, y ha sido demostrado que es posible relacionarla con otros parámetros ambientales para construir límites de predicción para nuevas observaciones. El objetivo de esta investigación fue establecer las relaciones entre la profundidad de disco de Secchi con la turbidez y Clorofila “a” para utilizarlas como base para estimar valores de turbidez y concentración de clorofila a partir de modelos matemáticos de ajuste de regresión simple. Este trabajo fue realizado en el periodo 2018 y 2019. Los resultados obtenidos a partir de las ecuaciones estimadas demuestran que es posible estimar y construir límites de predicción para nuevas observaciones de Turbidez y Clorofila en el embalse San Jacinto, mostrando un R2 y un grado de efectividad de la relación Turbidez y Zsd de 92.73% y un R2 en la relación Clorofila y Zsd de 96.05%. Conocer las relaciones entre los parámetros ambientales del agua, es fundamental para el seguimiento espacio- temporal, que permita una adecuada gestión de las aguas del embalse San Jacinto.
Epidemiological characteristics of whooping cough in Paraguay (2005-2019)
Authors: León Maria Eugenia , Kawabata Aníbal , Nagai Minako , Rojas Liliana , Melgarejo Nancy , Chamorro Gustavo
Published: August 2022

Objective: To describe the epidemiological characteristics of whooping cough in Paraguay. Methods: 5327 samples of children and adults of all ages with suspected whooping cough and their contacts were included in this study. 745 samples were processed per microbiological culture and 4582 samples per microbiological culture and PCR. Results: The overall frequency of cases and their laboratory-confirmed contacts was 9.1%. A total of 361 cases and 123 close case contacts were detected as positive. Positive cases were more common in the < 2 months (70.6%), followed by the 2-6 month (11.9%). Conclusion: In Paraguay it is a public health problem that mainly affects children under 2 months, who have not yet received the vaccine. Knowing the epidemiology of whooping cough or pertussis helps us to know the burden of the disease as well as to measure the effectiveness and impact of vaccines.
Perceraian Disebabkan Impotensi Menurut Ibnu Hazm
Authors: Novianti Novianti
Published: August 2022

Divorce has its own reasons. Among them because of shiqaq, violence, and others. But in fact, divorce can be done due to shiqaq for reasons of sexual dysfunction (impotence). This study specifically analyzes the Banda Aceh Syar'iyah Court Decision Number 434/Pdt.G/2020/Ms.Bna. If we review it based on Ibn Hazm's opinion, then the decision Number 434/Pdt.G/2020/Ms.Bna is very contradictory because impotence should not be used as a reason for divorce for married couples. The purpose of this research is to know that divorce is caused by impotence according to Ibnu Hazm, and to know the decision of the Banda Aceh Syar'iyah Court Judge Number 434/Pdt.G/2020/Ms.Bna in Ibnu Hazm's perspective. This research was conducted using a normative legal approach with library research. The data collected was studied through descriptive analysis methods and comparative methods. The results of the research analysis show that: First, Ibn Hazm argues that marriage cannot be legalized because of a defect or disgrace to the husband or wife. Ibn Hazm only admits that there are only eight types of marriage that can lead to marriage. For this reason, the marriage will continue until there are other causes as a way of separation. He only accepted the Faskh if ​​the hadiths were authentic, Ibn Hazm rejected the Faskh marriage on the grounds of a defect because there is no valid evidence or text in the Al-Quran, Sunnah, Ijmak, Qiyas or logic that allows the Fasach. Second, Judge MS. Bna saw that in the household there were often quarrels and disputes because the Defendant had sexual dysfunction (impotence) which caused the Defendant to be unable to provide spiritual support to the Plaintiff as husband and wife should. The family has reconciled, but the hope of living together is no longer there. Meanwhile, Ibn Hazm's view on the case was that he did not allow the judge to facilitate or give time for the marriage, but Ibn Hazm allowed it if it was the husband who dropped the thalaq on his wife.
Pengelolaan Harta Warisan Antar Ahli Waris
Authors: Hidayah Shofia
Published: August 2022

Abstract: Inheritance is property left by the testator after death. Inheritance in Islam is regulated in inheritance law, which is the law governing the transfer of property from a deceased person to a living family. In Islam, after a person dies, the inheritance he leaves must be immediately distributed to his heirs. But in fact, along with the development of the times, many things have changed, such as the inheritance distribution system in Islam, where people take the initiative to first manage their inheritance. Based on this, the authors are interested in researching this problem with the formulation of the problem, namely how are the practices, impacts, and views of Islamic law regarding the management of inheritance between heirs that occurred in Kayukul Village, Pegasing District, Central Aceh Regency. This research is a qualitative research with field research, the approach used is a normative-sociological approach. The legal materials used are primary legal materials and secondary legal materials sourced from books, scientific works and research results in the field. Data collection techniques used are observation and interviews. The result of this research is that in Gampong Kayukul the management of inheritance between heirs is carried out by working on and managing the estate in the form of a garden together which then the results are used for daily needs. Then the management of this inheritance has a positive impact on the individual or each heir, while the negative impact comes from external. Regarding the view of Islamic law on the management of inheritance between heirs, this is something that is permissible as long as there is a prior agreement between the heirs and there is the pleasure or willingness of all heirs.
Penerapan Sanksi Bagi Pelaku Nikah Siri Dalam Fatwa MPU Aceh Nomor 1 tahun 2010 Tentang Nikah Siri
Authors: Hanapi Agustin , Mauliana Sudjah
Published: August 2022

Some society assumed that all person who perform marriages under the hands or unregistered marriages are marriages that are carried out secretly without the knowledge of official officers, namely mariages record officer. Unregistered marriages become a problem in the community that can’t stop it soon, more harm than good. Unregistered marriages can also have a big impact on the consequences of the marriages law there is especially an bad effect on women and children. Now a days much of all still many unregistered marriages processed, because there are still many unofficial marriages with decision of false judge, therefore need for applicate the sanctions for the two perpetrators of unregistered marriages, in this case teh MPU Aceh have the create Fatwa about this problem one, so they must state a regulation to protect this habitual can not occur again in our community. Therefore, the researcher is interested in reviewing the application of sanctions for unregistered marriages perpetrators in MPU Aceh Fatwa No. 1 of 2010 concerning Siri Marriages. The research methods used are field research and literature research. The result in this study state that MPU Aceh applied sanctions for perpetrators of this series of marriages against false judge with imprisonment, the presence of false judge this unregistered marriages is viral now, therefore there needs to be sanctions applied. In the study of Maqasid Syar’iyah the recording of marriages agreements falls into the category of primary benefits of Daruriyat that can protect and maintain the benefit of religion, soul, reason, offspring, and property. Related to offspring, because with the recording, for women children benefif from the wife gets an inheritance and the child gets.
Nivolumab Versus Cetuximab In Recurrent/Metastatic Squamous Cell Carcinoma Of The Head And Neck. A Real-World Data Study
Authors: Rivas Lola Macía , Carbajales-Álvarez Mónica , Fernández-Laguna Clara , Álvarez-Asteinza Cristina , Maray-Mateos Iván , Lozano-Blázquez Ana
Published: August 2022

Aim

Assess the effectiveness and safety of nivolumab versus cetuximab in
patients with R/M HNSCC, as well as to analyze possible prognostic
factors for response to treatment with nivolumab.

Methods

We conducted an observational, retrospective, descriptive study of
patients with R/M HNSCC who initiated treatment with nivolumab or
cetuximab monotherapy in two periods of equivalent duration. Overall
efficacy was measured in progression-free survival (PFS) and overall
survival (OS); safety was evaluated using the CTCAE (Common Terminology
Criteria for Adverse Events) classification version 5.0 of the National
Cancer Institute (NCI).

Results

Median overall survival (OS) was 9.1 months with nivolumab (n=34) vs.
6.3 months with cetuximab (n=12)(HR=0.5; 95%CI: 0.24-1.03; p=0.058).
Progression free survival (PFS) were 4.3 for nivolumab and 4.65 months
for cetuximab (HR=0.59; 95%CI: 0.29-1.19; p=0.14). Any grade adverse
events (AEs) were reported in 97% and 100% of the patients treated
with nivolumab and cetuximab. Serious AEs were observed in 26% and 58%
of the patients respectively. Elevated albumin values, lymphocytosis,
neutropenia and elevated neutrophil/lymphocyte ratio values have
positive prognostic value on the response to nivolumab in R/M CCECC.

Conclusion

Effectiveness of nivolumab in terms of OS remains superior to cetuximab.
OS, PFS and severe or any grade AEs were superior in both arms of our
study than in the clinical trials. The AEs profile of nivolumab differs
in our study from the clinical trials’ observations. We have identified
four positive statistically significant prognostic variables on the
response to nivolumab in R/M HNSCC.
HMGB1 A Box binds to CXCR4 to inhibit HMGB1/CXCL12 mediating macrophage and T cell infiltration and prevents neuronal damage in Parkinson’s Disease
Authors: Tian Yu , Jiang Lin , Zhang Shiqing , Cao Yuwen , Liu Fang , Xia Lin , Su Zhaoliang
Published: August 2022

Background and purpose: Our previous work proved that HMGB1 A Box
significantly protected TH+ neurons in Parkinson’s disease (PD) model
mice and inhibited microglia activation and T cell infiltration
including Th17 in the substantia nigra (SN). This study explored the
mechanism of Th17 differentiation and how A Box inhibiting this process.
Experimental approach: Clodronate liposomes were used to deplete the
peripheral monocytes of mice, infused the labeled CD3+ T cells, and used
immunoprecipitation to knock down the primary cells HMGB1 in vitro. At
the same time, we combined the data of serum and blood cells of PD
patients to study. Key results: Depletion of peripheral
monocytes/macrophages reduced Th17 cell infiltration in the SN of MPTP
mice and protected TH+ neurons. Co-culture experiments with knockdown of
HMGB1 in primary cells showed that HMGB1, which induces
monocyte/macrophage migration and infiltration into the SN, originates
from neurons rather than glial cells. Data from MPP+-treated midbrain
cell models and assays associated with adoptive transfer of CD3+ cells
suggest that monocyte/macrophage and T cell migration into the SN is
mediated by HMGB1/CXCL12-CXCR4. Co-immunoprecipitation and
immunofluorescence confirmed that HMGB1 A Box bind to CXCR4 on T cells
and macrophages, thereby competitively inhibiting their infiltration in
SN. The HMGB1/CXCL12 complex is also present in the serum of PD
patients. Conclusions and implications: HMGB1 A Box protects TH+ neurons
by binding CXCR4 to inhibit the migration / infiltration of T cells and
macrophages to SN mediated by HMGB1 / CXCL12 complex formed by neuron
derived HMGB1.
Molecular Mechanisms of Anti-aging Traditional Chinese Medicine with “Homology of Medicine and Food”: Under the Influence of Oxidative Stress
Authors: Bai Yi-ling , Han Ling-ling , Wang Bai-xue , Wang Hao-zhong
Published: August 2022

Background: The biological process of aging is brought on by a variety
of variables and mechanisms, among which, the most comprehensive is the
aging process caused by oxidative stress. The theory of the “homology
of medicine and food”, originated from the thinking of traditional
Chinese medicine, has gained popularity in recent years, and is believed
to be utilized as a dietary therapy to ease the symptoms of aging.
Purpose: We searched the recent 10-year literature on the “homology of
medicine and food” traditional Chinese medicine to alleviate aging and
prolong life, and summarized its anti-aging mechanism under the
influence of oxidative stress. Experimental approach: Six electronic
databases, including China National Knowledge Infrastructure (CNKI),
Wanfang database, Chinese Scientific Journals Database (VIP), PubMed,
EMBASE, and Cochrane Library, were searched from June 2012 to June 2022
for identifying eligible studies. Key Results: The “homology of
medicine and food” traditional Chinese medicine mainly scavenges free
radicals, alleviates mitochondrial DNA damage, regulates telomeres and
telomerase, regulates nutrient and energy sensing signaling,
up-regulates sirtuins signaling pathway, and activates the
Keap1-Nrf2/ARE signaling pathway mechanisms delay aging and prolong
lifespan, and expect to find microcirculation mechanisms and new
targets. Conclusions & Implications: The “homology of medicine and
food” traditional Chinese medicine relieves the aging of the body and
cells under oxidative stress through 6 pathways and is expected to find
the correlation between the microcirculation formation mechanisms and
identify new research targets and factors, which will provide new
opportunities for life extension, prevention, and treatment of
age-related diseases.
The Evolutionary Basis for Human Empathy, Compassion and Generosity
Authors: Spikins Penny
Published: August 2022

How did we come to care so much for our loved ones, and to respond so readily to those in need? This chapter addresses these questions, considering our shared ancestry with other apes as well as selection pressures pushing our emotional dispositions more towards those of more distantly related primates and even social carnivores. If we look around at the types of empathy and emotional connections in other animals, we can gain some insight into the basic building blocks of our empathy, compassion and generosity. Studies of helping behaviour in other species can provide us with some important insights, for example. If we go back to basic roots as mammals we can see that this evolutionary history has formed the basis for our capacities for empathy, stemming from a need to respond to vulnerable young. However, human empathy, compassion and generosity is certainly more complex. This is where studies of our nearest living relatives, chimpanzees, provide insights into more complex capacities to share and to respond to others distress, as well as a certain social astuteness that is likely to have characterised the emotional capacities of our common ancestor living about 7 to 8 million years ago. What happened after our split with other primates? How our emotional capacities evolved after our lineage split with other apes is a challenging question. Here animal comparisons reveal a certain paradox. Some far more distantly related animals demonstrate a more human-like altruism and compassion than those that are most closely related to us, such as demonstrating a certain willingness to collaboratively care for offspring, or to care for vulnerable injured adults, for example. Understanding what prompted these kinds of changes in human ancestors who came after our split with the ancestors of chimpanzees demands considering how different species find the best ways of adapting to the ecological and social environments, and how this affects their emotional reactions to each other. Explaining the depth and breadth of our emotional connections to others remains a challenge. Building up our understanding of how and why human emotional motivations towards generosity and compassion emerged over the last few million years also depends on archaeological evidence of when helping and compassionate behaviours emerged, and why they became important, which is the focus of Chapter 2.
Design of benzimidazoles, benzoxazoles, benzothiazoles and thiazolopyridines as leukotriene A4 hydrolase inhibitors through 3D-QSAR, docking and molecular dynamics
Authors: Lorca Marcos , Faúndez Mario , Pessoa-Mahana David , Recabarren-Gajardo Gonzalo , Diethelm-Varela Benjamin , Millán Daniela , Celik Ismail , Mellado Marco , Araque Ileana , Mella Jaime , Romero-Parra Javier
Published: August 2022

Human leukotriene A4 hydrolase enzyme (LTA4H) catalyses the biotransformation of the inactive precursor leukotriene A4 (LTA4) to the bioactive Leukotriene B4 (LTB4), which causes many inflammatory responses in the human body. Therefore, the selective inhibition of this enzyme becomes a useful strategy for the treatment of several illnesses such as asthma, allergic rhinitis, cardiovascular diseases, and cancer. Herein we report a 3D-QSAR/ /CoMFA and CoMSIA study on a series of 47 benzimidazoles, benzoxazoles, benzothiazoles and thiazolopyridines reported as potent LTA4H inhibitors. Good statistical parameters were obtained for the best model (q2 = 0.568, r2 ncv = 0.891 and r2 test = 0.851). A new series of 10 compounds capable of inhibiting leukotriene A4 hydrolase with high potency was presented. All designed inhibitors showed low IC50 in nano- and sub-nanomolar ranges, when they were evaluated in 3D-QSAR models. Subsequently, the designed molecules, as well as the least and most active compounds were subjected to docking and molecular dynamics studies into LTA4H. In conclusion, we summarised a thorough structure?activity relationship (SAR) of LTA4H inhibitors of heterocyclic structure. These models can be used for the rational proposal of new inhibitors.
Glycemic Variability Patterns Strongly Correlate with Partial Remission Status in Children With Newly Diagnosed Type 1 Diabetes
Authors: Pollé Olivier G. , Delfosse Antoine , Martin Manon , Jacques Louis , Gies Inge , Brinker Marieke den , Seret Nicole , Lebrethon Marie-Christine , Mouraux Thierry , Gatto Laurent , Lysy Philippe A. , Group DIATAG Working
Published: August 2022

  

Objective: To evaluate whether indexes of glycemic variability may overcome residual β-cell secretion estimates in the longitudinal evaluation of partial remission in a cohort of pediatric new-onset type 1 diabetes patients.

Research Design and Methods: Values of residual β-cell secretion estimates, clinical parameters (e.g. HbA1C or insulin daily dose) and continuous glucose monitoring (CGM) from 78 new-onset type 1 diabetes pediatric patients were longitudinally collected during one year and cross-sectionally compared. Circadian patterns of CGM metrics were characterized and correlated to remission status using adjusted mixed-effects model. Patients were clustered based on forty-six CGM metrics and clinical parameters, and compared using non-parametric ANOVA.

Results: Study participants had a mean (±SD) age of 10.4 (±3.6) years at diabetes onset and 65% underwent partial remission at +3 months. β-cell residual secretion estimates demonstrated weak-to-moderate correlations with clinical parameters and CGM metrics (r²= 0.05-0.25, p<0.05). However, CGM metrics strongly correlated with clinical parameters (r² >0.52, p<0.05) and were sufficient to distinguish remitters from nonremitters. Also, CGM metrics from remitters displayed specific early morning circadian patterns characterized by increased glycemic stability across days (within 63-140 mg/dL range) and decreased rate of grade II hypoglycemia (p<0.0001), compared to nonremitters. Thorough CGM analysis allowed the identification of four novel glucotypes (p<0.001) that segregate patients into subgroups and mirror the evolution of remission after diabetes onset. 

Conclusion: In our pediatric cohort, combination of CGM metrics and clinical parameters unraveled key clinical milestones of glucose homeostasis and remission status during the first year of type 1 diabetes.  
MITONI Tradisi Slametan Kehamilan pada Masyarakat Jawa di Kabupaten Kampar
Authors: Ernanda Mia , Hasbullah Hasbullah , Yelly Salmaini , Wahid Abd
Published: August 2022

Penelitian ini bertujuan untuk mengetahui pelaksanaan dan makna tradisi mitoni bagi masyarakat Jawa di Desa Bukit Kemuning Kecamatan Tapung Hulu Kabupaten Kampar. Pendekatan yang digunakan dalam penelitian ini adalah metode kualitatif, pengumpulan data digunakan adalah observasi, wawancara, dan dokumentasi, sedangkan data dianalisi dengan metode deskripif kualitatif. Hasil penelitian dapat disimpulkan bahwa tradisi mitoni yang dilakukan adalah sebagai ucapan syukur atas kehamilan yang sudah mencapai tujuh bulan dan harapan akan keselamatan ibu dan bayi sampai proses kelahiran tiba. Tradisi ini sebenarnya sudah mulai mengalami pergeseran dan pengurangan unsur-unsur tradisi, tetapi tidak meninggalkan inti dari tradisi. Pelaksanakan tradisi mitoni yaitu Pertama, menentukan hari, dalam menentukan hari pada tradisi mitoni sudah tidak lagi berpedoman pada kalender Jawa dan hanya menentukan harinya saja yaitu hari selasa atau hari sabtu. Kedua tahap persiapan seperti meyiapkan peralatan dan bahan dalam pembuatan makanan yang akan disajikan serta perlatan yang dibutuhkan pada pelaksanaan tradisi mitoni, mengundang para tamu, dan memasak. Ketiga adalah tahap pelaksanaan, pada tahap ini pelaksanannya sudah tidak lengkap lagi hanya terdiri dari siraman, membelah kelapa dan kenduri, dan ada juga yang hanya melakukan kenduri saja. Adapun makna yang terdapat pada tradisi mitoni adalah adanya upaya untuk menjadikan sang anak memiliki jiwa dan badan yang kuat.
ZIARAH KUBUR PADA MASYARAKAT DESA MUARA MUSU KECAMATAN RAMBAH HILIR KABUPATEN ROKAN HULU
Authors: Rahmi Rahmi , Ghofur Abd , Khairiah Khairiah , Sarifandi Syuja'i , Arnel Iskandar
Published: August 2022

Penelitian ini bertujuan untuk mendeskripsikan ziarah kubur yang telah menjadi tradisi sebagian besar masyarakat di Desa Muara Musu Kecamatan Rambah Hilir Kabupaten Rokan Hulu. Ziarah kubur adalah kegiatan masyarakat mengunjungi makam-makam pribadi atau umum yang dilaksanakan secara individu maupun kelompok. Masyarakat berdoa agar kerabat atau anggota keluarga yang meninggal diberikan kelapangan dalam kuburnya dan diberi kedudukan yang layak oleh Allah SWT. Rumusan masalah penelitian ini adalah: pertama, bagaimana etika dan tata cara pelaksanaan ziarah kubur?, kedua, apa saja nilai-nilai yang ada dalam kegiatan ziarah kubur yang dilaksanakan oleh masyarakat di Desa Muara Musu Kecamatan Rambah Hilir Kabupaten Rokan Hulu? ?. Itu adalah penelitian lapangan: penelitian yang tidak menggunakan data yang dihitung. Penelitian ini menggunakan pendekatan kualitatif yang diarahkan untuk memberikan fakta atau peristiwa secara sistematis dan akurat. Metode wawancara, dokumentasi, dan observasi digunakan untuk mengumpulkan data. Analisis data adalah penguraian data untuk menghasilkan kesimpulan deduktif dan induktif. Temuan penelitian ini menunjukkan bahwa dalam ziarah kubur di desa Muara Musu memiliki keunikan, air kapur merupakan salah satu tata cara dalam ziarah kubur yang harus dibawa ketika akan berziarah, bertujuan untuk menyiram kuburan agar dingin. Kegiatan ziarah dilaksanakan pada hari-hari tertentu, misalnya pada hari Jumat, akhir bulan Ramadhan dan menjelang hari raya Idul Fitri. Kegemaran mereka melaksanakan ziarah kubur terkait dengan fenomena belajar agama melalui desa Sulukin. Sebab, mereka mendapat pengajaran yang baik dan mengandung unsur-unsur yang baik untuk masyarakat. Selain itu, ziarah kubur juga memiliki motivasi dan nilai-nilai kebaikan yang bertujuan untuk mengingatkan semua orang tentang kematian, agar hidupnya lebih baik yang dapat melatihnya untuk menerima dan bersabar dalam menghadapi setiap rintangan atau ujian dari Allah SWT
Optimization of Offshore Wind Farms Configuration Minimizing the Wake Effect
Authors: B. Jesus  , A. Cerveira  , J. Baptista
Published: August 2022

Currently, there has been a great development of the wind energy market, which is accompanied by an increase in the number of wind farms at sea, the offshore wind farms. Therefore, it is crucial to ensure that efficiency in energy production is maximum and that the levelized cost of energy (LCOE) is minimal. In this paper, a mixed-integer linear programming model (MILP) is proposed to find the best wind farm layout taking into account the wake effect in order to maximize energy production. The design of an offshore wind farm located at the North Sea is considered as a case study, contemplating three situations regarding the number of wind turbines to be installed and to determine the best positioning of them in order to maximize energy production, taking into account the wake effect and the lowest LCOE.
A Centralized Shifted Power Control Scheme for Isolated Bidirectional DC-DC Converter in Standalone DC Distribution System
Authors: Minh-Duc Pham  , Tuyen D. Nguyen  , Hong-Hee Lee
Published: August 2022

When parallel converter structures are considered in modern DC distribution systems, several challenges are faced in the energy management system (EMS). For example, the circuit parameter mismatches of parallel isolated DC-DC converter modules will cause power imbalances, which is the most important concern in DC distribution system. To deal with this issue, this study presents a power management control scheme in the EMS to ensure the power balance of isolated DC-DC converters in DC distribution system. In the proposed method, the proposed shifted voltage is introduced at the output of each converter to compensate the output impedance mismatches. Especially, the shifted voltage is flexibly determined according to the output current sharing error to obtain a balanced output impedance among converters, and the balanced power sharing is achieved by means of the modified voltage reference. The simulation results with the stand-alone DC distribution system are carried out to verify the effectiveness of the proposed control scheme.
Control Strategy for Power Generation from a Capacitive Mixing Cell and Grid Injection
Authors: Armel A. Nkembi  , Alberto M. Pernía  , Miguel J. Prieto  , Ana Arenillas  , J. R. Álvarez
Published: August 2022

In this work, the possibility of extracting energy from a capacitive mixing cell based on the potential that exists as a result of the salinity gradient between fresh and salt water passing through the electrodes of a deionization cell is studied. For this, a two-stage process is defined. The first step uses a dual buck-boost converter for the positive and negative cycles of the input voltage. This topology acts as a current source and is chosen due to its ability to provide high power factor and to work with extremely low voltage levels. The second stage consists of an H-bridge inverter synchronized with the AC grid to feed power into the grid. A hysteresis control system has been designed for the current flowing through the coil. With this, it has been analyzed how the efficiency of the total system (cell + power converter) varies with the changes in the series resistance of the CapMix cell or with the discharge current selected in the power converter. Simulations are carried out to characterize the energy extraction and some experimental results confirm the possibility of using this new renewable energy source.
System for repetitive battery charge and discharge tests for battery life analysis
Authors: F. Ciancetta  , E. Fiorucci  , A.Fioravanti  , S. Mari  , A.Prudenzi  , A. Silvestri
Published: August 2022

Lead-acid batteries are and will still be widely used to power various electrical systems. Unfortunately,these are found for most of the time at rest and by the time they are called to work,they could be out of order, creating real problems for critical infrastructures.The work aims to lead to the construction of a test system for verifying the performance and life of UPS batteries starting from the analysis of different batteries with equivalent characteristics. The first step serves to determine a standardization of the work and of the system to obtain a useful reference for the comparison and repetition of subsequent tests.
Daylighting system based on single-axis polar heliostat
Authors: L.M. Fernández de Ahumada  , M. Torres-Roldán  , M. Osuna-Mérida  , J.C. Ramírez-Faz  , R. López Luque  , M. Varo-Martínez
Published: August 2022

The fight against climate change makes it necessary, among other measures, to improve the energy efficiency of buildings. One way of doing this is to improve the levels of natural lighting inside buildings. In this sense, this paper analyses the possible use of heliostats as natural illuminators in an educational space. For this purpose, a classroom in the Leonardo da Vinci building of the Rabanales Campus of the University of Cordoba (Spain) and an illuminator system based on a single-axis polar heliostat have been reproduced at a scale of 1:15. These devices have been exposed to the same solar irradiance conditions and the illuminance levels registered inside both devices have been compared. It was found that there is an increase in daylighting levels in the recreated classroom ranging from 70.40% to 242.58% compared to the situation without heliostat illuminators. Therefore, it can be concluded that heliostats can play a fundamental role to improve the efficiency of buildings and, therefore, in the fight against climate change.
Autismo na escola: da construção social estigmatizante ao reconhecimento como condição humana
Authors: Vidal Santos Régia , Macedo Eunice , Ferreira Mafra Jason
Published: August 2022

Este artigo, de natureza teórica, apresenta argumentos que corroboram o reconhecimento do autismo como condição humana em contraposição à sua representação como um conjunto de déficits estigmatizantes. Para tanto, reúne fundamentos nos estudos sobre a condição humana e o pensamento alargado de Hannah Arendt; as apreciações acerca de comunicação entre diferenças e justiça social que emergem da obra de Iris Young; a perspectiva relacional e humanizante presente na obra de Paulo Freire; e a compreensão de dentro do próprio autismo apresentada por Temple Grandin. Constata-se que colocar em prática uma escuta educativa, implicada em compreender o autismo como condição humana, tanto quanto a análise – crítica, constante e conjunta – de discursos que negam a capacidade de pessoas autistas de participar em condições de igualdade da vida social, cultural e política, pode consolidar o verdadeiro encontro, aprendizado e crescimento humano na pluralidade.
Using empirical methods of perception in process of physical phenomenon concept making for students of engineering and technical specialities and directions
Authors: Revina Alla Victorovna
Published: August 2022

The ability of young specialists to quickly adapt to production and emerge into the general engineering process is one of the main requirements of employers for graduates of the higher educational institutions today in the development of modern society. In the higher technical school there is stated the urgency of raising the level of education in order to find the most optimal ways of improving the quality of acquiring fundamental knowledge, practical skills and abilities necessary the future graduates in their professional activities, which is regulated in the new Federal State Educational Standards. It has been found necessary to set a goal of organizing the educational process, the main component of which would be the professionally oriented activity of students. Then it becomes obvious that the process of perception is directly related to the developing the reality, accumulation and comprehension of data obtained during the interaction of the student with the environment. In accordance with generally accepted ideas in the scientific world, which correlate with the epistemological concept of cognizability of the world, the knowledge acquired by a person must undergo a test in the realities of practical activity. Based on the experience of working in the higher education system, it has been inferred that for students of a higher technical school it is especially important not only to test the theoretical knowledge gained by experience, but also to gain new knowledge in the learning process based on experimental data and possible further application of gained experience in professionally oriented activities.
Specific features of methodology for conducting experimental studies of adaptive control system of ship lifting devices
Authors: Popov Vladimir Vladimirovich , Ivanovskaya Aleksandra Vitalievna , Erofeev Valentin Leonidovich , Bogatyreva Elena Vladimirovna
Published: August 2022

Lowering and recovery operations, as well as towing underwater and surface objects are carried out with the help of a ship winch. As a result of the impact of any external disturbances, longitudinal oscillations appear in the towing rope, whose resonant maxima may fall into the vessel’s frequency range. The longer the cable, the greater the number of resonant frequencies in the operating range. Such operating conditions of the ship’s lifting equipment have a negative impact on the operation of the ship’s power plant as a whole. In order to increase the reliability of deck lifting equipment it is proposed to use an adaptive control system that would respond in a timely manner to changes in loading. Lifting equipment of a fishing vessel with non-stationarity of dynamic processes in operation is considered as an application of such a system. There is considered a principle of operation of the adaptive hydraulic drive of a trawl winch. The important scientific and technical problem of developing a complex mathematical model of the above control system has been solved. The directions of experimental research are determined. There is proposed a laboratory unit to evaluate the influence of the parameters of a mechanical system on the dynamics of a hydraulic drive of a load-lifting device adaptive to load variability. The unit operates due to changing the number and weight of the load discs installed on the driving and driven pulleys and simulating a change in the inertial coefficient, which is typical for a trawl winch. The second direction of experimental research is the verification of the adequacy of the obtained mathematical models. There are presented the results of the verification in the form of calculated and averaged experimental dynamometer cards, which are well correlated, with deviation up to 8%.
Influence of caprolone stern-shaft bearings on propeller shaft operation
Authors: Khalyavkin Aleksey Aleksandrovich , Starkova Maria Vladimirovna , Bondarenko Viktor Valentinovich , Gordon Vladimir Aleksandrovich , Mamontov Victor Andreevich
Published: August 2022

The paper considers the conditions for reliability of the ship rudder-propeller complex, whose operation depends on the status of the stern bearings of the ship shafting. Stern bearings are plain bearings located in the vessel's stern tube, they support the propeller shaft of the ship’s shafting. The stern tube is similar for all types of ships, inside which there are located the bearings and a sealing device that prevents ingress of outboard water inside the vessel. It is pointed out that the stern bearings made of caprolone have certain advantages over other traditionally used materials. The numerical values of the main parameters of caprolone stern bearings are presented on the basis of normative and regulatory documents. It is stated that physical and mechanical properties of caprolone in almost all respects are higher than those of other materials currently used for this purpose. Along with strength and high load capacity, caprolone has a low friction coefficient (0.04-0.08). To study the contact of the propeller shaft with the stern bearing there is considered a design diagram (a beam resting on an elastic base with a stiffness coefficient k). The stiffness coefficient of the elastic foundation characterizes the elastic and mechanical properties of the stern bearing. It is proved that caprolone used in stern bearings allows increasing the reliability of the ship’s shafting by full contact with the propeller shaft, reducing vibration and noise, resisting the erosion wear, and increasing safety
The right to work as a fundamental human right and the relationship between quaranter restrictions and the right to work
Authors: Tikhonyuk O.V. , Yarosh I.S.
Published: August 2022

The article is devoted to the issue of the fundamental nature of the right to work and its relationship with quarantine restrictions. The relevance of this topic is the need to clarify the fundamental questions of the expediency of restricting the right to work of unvaccinated workers, to answer the question of whether it is appropriate to restrict the fundamental right that ensures human existence.

It is emphasized that the right to work throughout history has been fundamental to a person, which allows them to exercise other rights. It is indicated the place of the right to work in the concept of human rights. The issue of normative enshrinement of the right to work in the Constitution of Ukraine is raised and it is pointed out that the Constitution of Ukraine does not contain a clear indication that the right to work may be limited.

The article reveals the content of the right to work in the context of the state's obligations to provide the population with work and guarantee equal opportunities. The state must guarantee everyone real access to work in order to ensure the human right to exist.

Analyzing the relationship between the right to work and quarantine restrictions, the authors draw attention to the fundamental content of the right to work, as well as established guarantees of equal opportunities for the right to work. In view of this, the purpose of quarantine restrictions and a broad interpretation of the right to work is considered.

It is concluded that the right to work should not be restricted, and quarantine restrictions are disproportionate to the right to work. Quarantine is temporary, and the state is obliged to ensure that measures related to it do not limit a person's ability to exercise his or her right to work, receive wages or other living resources in the long run. Dismissal can be seen as pressure on workers in order to force them to be vaccinated. It can be seen as discrimination in the workplace, which is unacceptable in the light of previous statements by the state.