bluuebunny/crossref_metadata_2025 huggingface dataset:
Quantitative Analysis of Quantum Mechanics/Molecular Mechanics Boundary Artifacts and the correction in Adaptive QM/MM Methods
Authors: Watanabe Hiroshi C. , Cui Qiang
Published: March 2019

The incorporation of quantum chemical effects of solvation into molecular dynamics simulation has been a challenging issue due to solvent diffusion. To this end, various adaptive quantum mechanics/molecular mechanics (QM/MM) methods have been proposed, in which free solvent exchanges are allowed via a flexible switching of their identities between QM and MM models according to their distances from the QM solute. However, temporal and spatial discontinuities that remain in the standard implementations continue to hamper stable and accurate dynamics simulations using adaptive QM/MM approaches. We previously demonstrated that the size-consistent multi-partitioning (SCMP) method achieved temporal continuity while avoiding spatial discontinuities to some extent. In the present study, however, we demonstrate that the residual spatial discontinuity may lead to severe problems under certain conditions; via quantitative analysis, we show that not only adaptive QM/MM but also all multiscale approaches might share these problems implicitly, which have not been investigated in depth so far. To alleviate these artifacts, we propose a correction based on the SCMP approach and conduct benchmark simulations using bulk water systems.
How Chemistry Computes: Language Recognition by Non-Biochemical Chemical Automata
Authors: Dueñas-Diez Marta , Perez-Mercader Juan
Published: March 2019

This manuscript contains the experimental realization of one instance of each automata in the theory of computation using chemistry and not using biochemistry. All automata are implemented in a 1-pot reactor. The Finite Automaton (FA) is represented by a precipitation reaction, the 1-stack Push Down Automaton (PDA) by a pH reaction network and the Turing machine (TM) by the Belousov-Zhabotinsky chemical reaction. The computation (consisting on recognizing if chemically transcribed abstract sequences belong to appropriate languages in the Chomsky hierarchy) is carried out by a chemical reaction recognizing the molecules and their order. Once the sequence is introduced in the reactor (very much as mRNA is introduced in the ribosome) the reaction does all the recognition without any need for external not strictly chemical help from reaction/diffusion set-ups or chemical gates. The result of the computation has a straightforward thermodynamic/information theory interpretation. These results are of interest for soft-robotics, chemically self-assembled systems, chemical neural networks, artificial intelligence and of course chemical computing (i. e., computing done by chemistry at molecular scales which translates to larger scales by the power of Avogadro's number) as well as natural computing and analog/digital computing.
Location-dependent maintenance of intrinsic susceptibility to mTORC1-driven tumorigenesis
Authors: Rushing Gabrielle V , Brockman Asa A , Bollig Madelyn K , Leelatian Nalin , Mobley Bret C , Irish Jonathan M , Ess Kevin C , Fu Cary , Ihrie Rebecca A
Published: March 2019

Neural stem/progenitor cells (NSPCs) of the ventricular–subventricular zone (V-SVZ) are candidate cells of origin for many brain tumors. However, whether NSPCs in different locations within the V-SVZ differ in susceptibility to tumorigenic mutations is unknown. Here, single-cell measurements of signal transduction intermediates in the mechanistic target of rapamycin complex 1 (mTORC1) pathway reveal that ventral NSPCs have higher levels of signaling than dorsal NSPCs.These features are linked with differences in mTORC1-driven disease severity: introduction of a pathognomonicTsc2mutation only results in formation of tumor-like masses from the ventral V-SVZ. We propose a direct link between location-dependent intrinsic growth properties imbued by mTORC1 and predisposition to tumor development.
La Epidemiología Social en el desarrollo de la investigación en medicina tradicional y complementaria
Authors: Angulo-Bazán Yolanda
Published: March 2019

La Epidemiología Social es la rama de la epidemiología encargada de entender cómo las características económicas y sociales pueden influenciar el estado de salud de la población. Se considera que esta rama está muy relacionada con la caracterización de los determinantes de la salud, tanto en su distribución social como en las ventajas y desventajas que brindan en una población de estudio.
Efecto antioxidante del extracto hidroalcohólico de Calceolaria engleriana Kraenzl “wawillay” in vivo en ratones con lesión hepática
Authors: Mendoza-Romero Farah , Arroyo-Acevedo Jorge
Published: March 2019

Objetivos. Evaluar el efecto antioxidante del extracto hidroalcohólico de Calceolaria engleriana Kraenzl “wawillay” in vivo mediante el uso de ratones con lesión hepática inducida por tetracloruro de carbono (CCL4). Materiales y métodos. Estudio experimental. Se utilizó cuatro grupos de seis ratones albinos Mus musculus - cepa Balb/c/CNPB: un grupo blanco, un grupo control que recibió vitamina E (Vitesol® E 400 U.I) y dos grupos a los que se les administró extracto hidroalcohólico de Calceolaria engleriana Kraenzl “wawillay” en dosis de 50 y 300 mg/kg. Para la evaluación del efecto antioxidante in vivo se sometió a los ratones a un modelo experimental de hepatotoxicidad por tetracloruro de carbono (CCL4) antes y durante las intervenciones. Mediante la reacción del ácido tiobarbitúrico se cuantificó el malonaldialdehido (MDA) formado y se calculó el porcentaje de inhibición de peroxidación lipídica (POL) con el que se establecieron diferencias por grupos. Resultados. El tamizaje fitoquímico mostro la presencia muy abundante de flavonoides. Los porcentajes de inhibición de la POL obtenidos fueron de un 22 y 45%, para las dosis de 50 y 300 mg/kg del extracto hidroalcohólico. Si bien se encontraron diferencias significativas en la comparación entre grupos (p>0,05), las intervenciones experimentales no superaron los resultados del grupo control con vitamina E (60%). Conclusiones. En las condiciones experimentales, el extracto hidroalcohólico de Calceolaria engleriana Kraenz “wawillay” a dosis de 50 y 300 mg/kg presenta actividadantioxidante, siendo esta aun menor a la mostrada por el estándar (vitamina E).
Вопросы радикальности хирургического лечения злокачественных опухолей сердца
Authors: Vitovsky R. M. , Dyadyun D. N. , Isaienko V. V. , Onishchenko V. F. , Pishchurin A. A. , Martyshchenko I. V.
Published: March 2019

Цель. Определить методы диагностики и хирургического лечения, направленные на максимально радикальное удаление злокачественной опухоли сердца.

Материалы и методы. В Институте сердечно-сосудистой хирургии имени Н. М. Амосова НАМН Украины с 1970 по 01.01.2018 г. проведено лечение 912 пациентам с опухолями сердца, в том числе 63 (6,9%) пациентам со злокачественными новообразованиями сердца различного вида и локализации.

Результаты. Операции выполнены 62 больным, из них у 51 (82,3%) - с использованием искусственного кровообращения. Госпитальная летальность при хирургическом лечении злокачественных опухолей сердца составила 22,6% (умерли 14 больных). У 20 (32,3%) больных, которым выполнены условно радикальные кардиохирургические вмешательства с использованием искусственного кровообращения, отмечен хороший гемодинамический эффект.

Выводы. Для достижения условной радикальности операции и максимального гемодинамического эффекта в целом ряде наблюдений необходимо применение расширенных методик реконструкции поврежденных структур сердца в сочетании с активной дезинтоксикационной терапией и безотлогательной химиотерапией.
Особливості діагностики та комплексного лікування артеріовенозних форм вроджених судинних мальформацій кінцівок
Authors: Chernukha L. M. , Kashyrova O. V.
Published: March 2019

Мета. Поліпшення  результатів лікування хворих з артеріовенозними формами вроджених судинних мальформацій (АВФ ВСМ) кінцівок на основі розроблення диференційованих алгоритмів діагностики та лікування.

Матеріали і методи. Робота базується на даних комплексного клінічного дослідження та результатах хірургічного лікування 155 пацієнтів з АВФ ВСМ кінцівок. Строки спостереження становили від 1 міс до 10 років. Чоловіків було 65 (42%), жінок - 90 (58%), число чоловіків і число жінок співвідносилися як 1: 1,4. Середній вік пацієнтів становив (25,1 ± 10,4) року. У віці до 18 років (дитяча вікова група) було 53 (34%) хворих. Клінічний матеріал аналізували в залежності від клініко-анатомічних форм захворювання, які були розподілені на 11 груп на основі робочої класифікаційної схеми «VASC + Т».

Результати. Розроблення класифікаційної схеми вроджених судинних мальформацій уможливило поліпшення формування плану діагностики та етапного лікування пацієнтів у вигляді алгоритмів у залежності від клініко-анатомічної форми захворювання. Застосування етапного комплексного підходу з використанням емболізаційних, ендовенозних та хірургічних методик дало змогу уникнути розвитку великих післяопераційних ускладнень.

Висновки. Впровадженням розробленої тактики досягнутo задовільних віддалених результатів лікування у 136 (94,4%) пацієнтів.
Хірургічне лікування ускладненого аневризматичного субарахноїдального крововиливу
Authors: Polkovnikov O. Yu.
Published: March 2019

Мета. Покращення результатів хірургічного лікування ускладненого аневризматичного внутрішньочерепного крововиливу. Матеріали і методи. Із 213 хворих з субарахноїдальним крововиливом внаслідок розриву церебральних аневризм у 121 (56,8%) хворого констатовано ускладнений перебіг. Усім цим хворим проведено хірургічне лікування, яке передбачало оклюзію аневризми. Результати. У 68 (56%) хворих застосовано мікрохірургічне кліпування, у 53 - ендоваскулярну емболізацію. Хірургічні втручання у 84,3% хворих виконані протягом перших двох тижнів. У ряді спостережень застосовано комбіноване та багатоетапне хірургічне лікування. Позитивну динаміку отримано у 75 (61,9%) хворих, у тому числі у 59 (48,8%) хворих - хороший функціональний результат (1 - 2 ступінь інвалідизації за модифікованою шкалою Ренкіна). У 23 (19%) хворих результат був несприятливий (4 - 5 ступінь інвалідизації). Померли 23 (19%) пацієнти. Висновки. Назріла потреба в нагальному напрацюванні уніфікованої класифікації ускладнень аневризматичного внутрішньочерепного крововиливу, вивченні ефективності різноманітних хірургічних методів лікування та визначенні критеріїв вибору методу та термінів виконання втручання у залежності від типу внутрішньочерепного крововиливу.
Модель минно-взрывной травмы
Authors: Chizh N. A. , Kovalov G. A. , Belochkina I. V. , Mikhailova I. P.
Published: March 2019

Цель. Создание доступной модели минно-взрывной травмы различной степени тяжести у крыс. Материалы и методы. Взрывное повреждение мягких тканей бедра крыс моделировали с помощью строительно-монтажного пистолета (СМП) и специально разработанной стойки, которая обеспечивала фиксацию СМП во время выстрела. Для имитации повреждения от поражающих элементов в стволе СМП размещали стальные осколки. Результаты. Макроскопическая оценка повреждений показала, что они имеют признаки, характерные для поражения мягких тканей ударной волной, струей пламени, поражающими элементами. Показана возможность варьировать степень поражения тканей за счет мощности порохового заряда, отсутствия или наличия поражающих элементов. Выводы. Предложенная модель воспроизводит минно-взрывную травму и может быть использована в любой научно-исследовательской лаборатории, занимающейся вопросами экспериментальной медицины.
Yeşil Tedarik Zincirinde Tam Zamanında Dağıtım Modellemesi
Authors: ENGİN Batuhan Eren , PAKSOY Turan
Published: March 2019

Son kullanıcılara malların doğru zamanda dağıtımı günümüz
rekabetçi piyasasında önemli bir rol oynamaktadır. Bu bağlamda, yöneticiler,
ekonomik ve çevresel hedefleri doğrultusunda uygun bir çözüm bulma gayreti
içindeyken aynı zamanda, ürünlerin talep noktalarına tam zamanında teslim
edilmesini ve böylece stok maliyetlerinin düşürülmesini de sağlamalıdırlar. Bu
çalışma, dağıtım noktaları ve perakendecilerdeki stok tutma ile talebi doğru
zamanda karşılamak arasındaki ilişkiyi ve dolayısıyla stok tutma maliyetleri
ile ve karbon emisyonları arasında ilişkiyi araştırmayı hedeflemektedir. Bu
sebeple, fabrika, depo ve perakendecilerden oluşan üç kademeli dağıtım ağı
geliştirilmiş ve üç amaç fonksiyonu; 
toplam dağıtım ve üretim maliyeti, depolarda ve perakendecilerde
ürünlerin depolanması ve elleçlenmesiyle ilişkili toplam karbon emisyonu ve
perakendecilerden ardısmarlanmış (karşılanamamış, sonraya ertelenen, ingilizce:
backordered) ürünlerin ve talep fazlası ürünlerin sayısı olarak belirlenmiştir.
Geliştirilen model, hangi üreticiden, depolara ve oradan perakendecilere,
perakendecilerin talebine cevap vermek için ne kadar miktarlarda taşınacağını,
hangi fabrika ve depoların hangi boyutlarda açılacağını, depolardaki envanter
miktarlarını da belirlemektedir. Bu çok amaçlı tam zamanında dağıtım
modellemesi içeren yeşil tedarik zinciri modelinin çözümü için Tiwari, Dharmar ve Rao (1987) tarafından geliştirilen
bulanık ağırlıklandırma yaklaşımı ilk defa kulanılmıştır. Pratik açıdan,
çelişen ve farklı birimlere sahip amaçların aynı anda optimize edilmesine
olanak verdiği için bu yöntem, yöneticiler ve karar vericiler açısından önem
taşımaktadır. Bu bulanık edinim yöntemi, yöneticilerin her bir hedef işlev için
göreli önemlerini belirlermesine imkan sağlaması da ayrıca önemlidir, çünkü bu
sayede yöneticiler, hedeflerin de birbirlerine göre önem derecelerini kendi
tedarik zincirlerine göre belirleyebilirler.
Leticia: nueva variedad mexicana de nochebuena para interiores
Authors: Canul Jaime , García Pérez Faustino , Rangel Estrada Sandra Eloísa , Barrios Gómez Edwin Javier , Ramírez Rojas Sergio Gavino , Portas Fernández Blanca
Published: March 2019

La nochebuena (Euphorbia pulcherrima Willd. ex Klotzsch) es originaria de México y Mesoamérica. Su cultivo depende de variedades mejoradas provenientes del extranjero, lo que ocasiona fuga de divisas y pérdidas económicas. Actualmente está restringida su importación. Esto representa una oportunidad para ofertar variedades generadas en el país. El INIFAP, Campo Experimental Zacatepec realiza la mejora genética de nochebuena. Así, en 2010 por cruza manual entre MOR13 x MORPR10 se obtuvo progenie F1, la cual se evaluó en 2011 y en el ciclo inmediato se incrementó el número de plantas. En 2013 se injertó por cuña la progenie híbrida clonal (púa) con una variedad comercial (patrón), en 2014 se obtuvieron esquejes del injerto, se cultivaron hasta planta terminada y se seleccionó de acuerdo al biotipo que demanda el mercado. En 2015 se evaluó en vivero en Tetela del Monte, Cuernavaca, Morelos. En 2016 se realizó la descripción varietal con denominación de Leticia. Esta variedad presenta porte intermedio de gran amplitud con ramificación intermedia, hojas de forma oval de gran tamaño con peciolos de longitud media, brácteas de forma elíptica y de color rojo. Es de respuesta intermedia, la pigmentación de brácteas se presenta nueve semanas después del inicio de otoño.
Incidencia y severidad del tizón común en plantas de frijol inoculados con Rhizobium phaseoli
Authors: Aguilar Ramírez José Osvaldo , Gallegos Morales Gabriel , Hernández Castillo Francisco Daniel , Cepeda Siller Melchor , Sánchez-Aspeytia David
Published: March 2019

El tizón común bacteriano Xanthomonas axonopodis pv. phaseoli es una enfermedad que ataca al cultivo de frijol (Phaseolus vulgaris), se encuentra presente 83% de las áreas de producción de semilla y hasta 79% en campos comerciales y reduce los rendimientos hasta 55%. La inoculación de Rhizobium en plantas como promotor de crecimiento vegetal, fijador de nitrógeno, a la síntesis del ácido indolacético, producen en la planta mayor vigor y tolerancia a las enfermedades. Se determinó el comportamiento de la incidencia y severidad del tizón común de plantas de frijol inoculadas con Rhizobium phaseoli y X. axonopodis pv. phaseoli. Para ello se aislaron cepas de Rhizobium (FM-1, N-2, PS-3, M-4, BJ-5) de nódulos radiculares de plantas de frijol y Xanthomonas (Xant 1) de manchas foliares necróticas. Los aislados se identificaron con base en características morfológicas celulares, coloniales y bioquímicas. Los ensayos en invernadero y en campo, se efectuaron en semillas inoculadas con 106 ufc mL-1 de Rhizobium y una segunda aplicación a los 10 días después de la siembra. Posteriormente 15 días después de la emergencia del frijol se inoculó por aspersión Xanthomonas axonopodis directamente a la planta. Transcurridos 30 días del cultivo en invernadero se observó que la severidad del tizón común fue inferior en plantas con presencia de nódulos en raíz (14.5%), que en el testigo (46%), también se encontró que las plantas inoculadas con Rhizobium phaseoli BJ-5 desarrollaron mayor vigor, diámetro de tallo, peso seco, número de hojas y longitud de raíz. En campo, la inoculación con la cepa BJ-5 mostró menor severidad (25.6%) respecto al testigo (55.8%) y resultó tener mejor crecimiento en la planta. La inoculación de frijol con Rhizobium phaseoli permite favorecer nutricional y fitosanitariamente al cultivo.
Caracterización de la producción de maguey en el Distrito de Miahuatlán, Oaxaca
Authors: Cuevas Reyes Venancio , Sánchez Toledano Blanca I. , Borja Bravo Mercedes , Espejel García Anastacio , Sosa Montes Mauricio , Barrera Rodríguez Ariadna I. , Saavedra García Máximo Jorge
Published: March 2019

El objetivo del presente estudio es caracterizar el sistema de producción del maguey en el Distrito de Miahuatlán con la finalidad de identificar los tipos de productores y las características que los diferencian. Se utilizó Muestreo estratificado para seleccionar una muestra representativa de 81 productores de maguey del Distrito de Miahuatlán en el estado de Oaxaca. El uso de métodos multivariados permitió identificar tres tipos de productores; productores de subsistencia (n=36, 44.4%), productores de baja escala productiva (n=31, 38.3%) y productores de escala media (n=14, 17.3%). El estudio muestra que la producción de maguey se realiza de forma tradicional, aunque una gran cantidad de los productores realizan la preparación del terreno con maquinaria (entre 38.5 y 67.9%), una pequeña cantidad de ellos cuentan con asistencia técnica (entre 25 y 39%) y menos del 15.4% realiza la certificación de las plantaciones de maguey. Se concluye que más del 70% de la producción de maguey obtenida por los pequeños productores se encuentra integrada a la producción de mezcal, lo que demanda estrategias diferenciadas de apoyo para mejorar los procesos productivos por tipos de productores y mantener la producción de mezcal de forma tradicional, que mejore los ingresos de las pequeñas unidades familiares que mantienen la producción de esta bebida.
Identificación y distribución de Meloidogyne spp. en tomate de Sinaloa México
Authors: Martínez Gallardo José Ángel , Valdés Tomás Díaz , Molar Raúl Allende , Manjarrez Jesús Enrique Retes , Carrillo Fasio José Armando
Published: March 2019

A nivel mundial el género de nematodos fitoparásitos de mayor importancia es Meloidogyne, ya que afecta más de 3 000 especies de plantas y su infección se caracteriza por la formación de agallas en la raíz de la planta infectada. En Sinaloa se desconoce la distribución actual de Meloidogyne, debido a que los reportes más recientes son del año 2000 y 2001, identificando a las especies M. incognita, M. arenaria, M. hapla y M. javanica, distribuidas en el estado. En el presente trabajo de investigación los objetivos fueron identificar morfológicamente y molecularmente las especies del nematodo agallador (Meloidogyne spp.), así como, determinar su distribución en el cultivo de tomate (Solanum lycopersicum L), en Sinaloa, México. Se muestrearon lotes cultivados con tomate en las distintas zonas hortícolas de Sinaloa, México, durante los ciclos agrícolas 2013-2014, 2014-2015, 2015-2016 y 2016-2017, en campo abierto, malla sombra e invernaderos, donde se colectaron muestras de suelo y raíces agalladas, para realizar identificación morfológica y molecular. Las especies identificadas en las muestras colectadas fueron M. enterolobii, M. incognita y M. arenaria con 88, 10 y 2% de incidencia respectivamente. Estos resultados indican que M. enterolobii, M. incognita y M. arenaria se encuentran distribuidos en el estado de Sinaloa en el cultivo de tomate, siendo M. enterolobii la especie predominante.
Germinación de cultivares de frijol con características físicas contrastantes bajo condiciones de estrés osmótico
Authors: Aguilar Benítez Gisela , Vázquez Díaz Estefanía Grizel , Castro Rivera Rigoberto , Cruz Crespo Elia , Jarquin Gálvez Ramón
Published: March 2019

El cultivo de frijol común (Phaseolus vulgaris L.) en México ocupa el tercer lugar por superficie establecida, aunque la producción reporta variaciones anuales por la heterogeneidad de condiciones climáticas en las que se produce. Dada la importancia cultural y alimenticia de esta leguminosa, los agricultores y genetistas han seleccionado cultivares con características culinarias deseables y adaptaciones a ambientes restrictivos. El objetivo fue caracterizar la germinación de cultivares de frijol recolectados en Valles Centrales de Oaxaca y el Altiplano Potosino, regiones con ambientes y cultura contrastantes. En el laboratorio de Fitoquímica del Instituto de Investigación de Zonas Desérticas, durante el verano de 2015 se evaluaron cinco cultivares tradicionales y diez cultivares mejorados de frijol. Se cuantificó el porcentaje de germinación con los procedimientos de la prueba estándar descrita por ISTA (2005) y se seleccionaron las semillas que mostraron menor incidencia de contaminación por hongos y mayor porcentaje de germinación. Con cuatro cultivares mejorados y cuatro cultivares tradicionales se determinó el peso promedio de una muestra de 100 semillas y la proporción de estructuras seminales. También se registró el efecto de tres potenciales osmóticos en la germinación (Ψo: 0, -0.5 y -1.1MPa). Se observaron diferencias (p≤ 0.05) en el peso de 100 semillas, el porcentaje de la testa y eje embrionario. En Ψo: 0.0 Mpa y -0.5 Mpa se obtuvieron diferencias (p≤ 0.05) entre los cultivares evaluados. En Ψo: -1.1 Mpa la germinación fue nula en todos los cultivares.
Estrategia de centros de consolidación para la distribución de tuna en México
Authors: Granillo Macias Rafael , Gonzalez Hernandez Isidro Jesus , Santana Robles Francisca , Martinez Flores Jose Luis
Published: March 2019

El cultivo de la tuna (Opuntia spp.) ha posicionado a México como líder mundial en producción de este producto agroalimentario. Debido a que la cosecha se envía a diferentes mercados a lo largo del país, las operaciones de distribución y comercialización representan un reto en esta cadena de suministro. Esta investigación se realizó con base en la producción nacional obtenida en 2016, con el objetivo de desarrollar una red de distribución que maximice las ganancias de los productores. La hipótesis fue que con base en una estrategia de centros de consolidación es posible diseñar un modelo para una red de distribución que seleccione las rutas óptimas a partir de los costos de transporte y los precios de venta en los mercados demandantes. Se utilizó programación lineal entera mixta con variables continuas para determinar las cantidades de productos a enviar y variables enteras para seleccionar los centros de consolidación. El modelo propuesto se implementó; a través, de un algoritmo programado en Matlab el cual aplica técnicas de optimización matemática para evaluar la mejor solución factible. Los resultados indican que se deben utilizar cuatro centros de consolidación en el estado de Guanajuato, diez en Zacatecas, uno en Hidalgo y Puebla respectivamente, dos en el Estado de México y seis en San Luis Potosí. Con esta propuesta, el estado de Zacatecas concentra por lo menos 50% de la cosecha, por lo que esta ubicación es clave para optimizar la ganancia en la cadena de suministro de la tuna.
Discovering ditch buried volcanic materials: geoelectric method assistance to minimize hazard loss
Authors: Simpen I Nengah , Pratiwi Ni Made Widya
Published: March 2019

The current study is aimed at discovering ditch buried volcanic materials: geoelectric method assistance to minimize hazard loss. The research has been conducted at Bugbug Karangasem Bali. This covered by volcanic material from the eruption of Mount Agung in 1963 and before. Of course, there is a ditch as a land boundary. Based on the measurement results of the geoelectric method, it was found that there was a low resistivity area of 26.5 ?.m at a depth of about 7 m area A and 23.5 m (area B). Based on the excavation at several points, the thickness of the volcanic material layer in the study area is around 7 m. The landowners have claimed that their land is restricted by a ditch, which when Mount Agung erupted in 1963, had been covered with volcanic material; a ditch was made, but between the trenches made with the low-resistivity area A sideways again 11 m. The low resistivity is thought to be a buried ditch. As it is connected to the two cases above, namely the case of the results of geoelectric measurements and cases of landowners' suitability. The ditch that has been buried by volcanic material can be detected by geoelectric methods assistance.
Penataan Administrasi Kependudukan Berbasis Mukim dan Gampong di Provinsi Aceh
Authors: Jafar M , Sulaiman Sulaiman
Published: March 2019

Ada sistem pemerintahan yang khas di Aceh, yakni berbasis mukim dan gampong. Sistem pemerintahan ini secara formal diatur dalam Undang-Undang No. 11 Tahun 2006 tentang Pemerintahan Aceh. Artikel ini ingin menjawab permasalahan terkait bagaimana peran pemerintahan mukim dan gampong dalam penataan administrasi kependudukan di Provinsi Aceh. Penelitian ini merupakan gabungan penelitian normatif (mengkaji perundang-undangan) dan empiris (melihat bekerjanya hukum). Spesifikasi penelitian, ingin melihat sejauhmana hukum yang mengatur mukim dan gampong bisa diterapkan terhadap sistem administrasi kependudukan. Administrasi kependuduk adalah salah satu bagian dari pelayanan publik yang diberikan negara kepada warganya untuk memenuhi hak-hak warga negara. Oleh karena itu, pengelolaan administrasi sipil harus didasarkan pada sistem yang ada yang sesuai dengan aturan sehingga akan menghasilkan data sipil yang benar. Hal ini dihasilkan dari data sipil yang akurat dapat digunakan di beberapa bidang untuk mendukung pembangunan. Pemerintah Aceh disarankan melakukan penguatan terhadap mukim dan gampong untuk membantu proses pembangunan hingga pada tingkat bawah.
Adopsi Hukum Asing ke dalam Hukum Nasional (Tinjauan terhadap Perjanjian Bank Syariah)
Authors: Djuniarti Evi
Published: March 2019

Telah terjadi pencangkokan ketentuan-ketentuan perjanjian KUHPerdata (tranplantasi hukum perjanjian) pada akad pembiayaan bank syariah yang seharusnya secara keseluruhan berdasarkan ketentuan-kekentuan perjanjian menurut hukum Islam, dalam praktek perbankan syariah sudah seharusnya menuangkan syarat dan rukun sebagaimana ketentuan yang terdapat di dalam syariat Islam begitu pula ketika menuangkan ke dalam akad.  Praktik riba tidak meningkatkan kekayaan secara merata tetapi justru terakumulasi pada segelintir orang pemilik modal. Perumusan masalah dalam tulisan ini adalah bagaimana penerapan tranplantasi hukum perjanjian pembiayaan menurut KUHPerdata ke dalam hukum perjanjian mudharabah muqayyadah pada Bank BNI Syariah dan bagaimana ketentuannya jika terjadi wanprestasi pada perjanjian pembiayaan mudharabah muqayyadah. Metode dalam penulisan yaitu penelitian yuridis normatif. Penelitian ini berbasis pada analisis terhadap peraturan perundang-undangan yang ada. Adopsi hukum sebagai upaya untuk mempermudah proses pelaksanaan hukum pada suatu negara, salah satunya adalah dalam perjanjian syariah
Kebijakan Kredit yang Dihapusbukukan atau Dihapus Tagih oleh Bank BUMN dalam Perspektif Kepastian Hukum
Authors: Sudjana Sudjana
Published: March 2019

Kajian ini bertujuan untuk memperoleh informasi tentang ketentuan yang mengatur penyelesaian kredit bermasalah yang dihapusbukukan atau dihapus tagih oleh Bank Badan Usaha Milik Negara. Metode Penelitian yang digunakan adalah metode pendekatan undang-undang (statuta approach), metode pengumpulan data melalui studi kepustakaan dan teknik analisa data normatif kualitatif. Hasil kajian menunjukan bahwa Ketentuan Penyelesaian kredit bermasalah yang dihapusbukukan atau dihapus tagih oleh Bank Badan Usaha Milik Negara dari sisi substansi hukum kontradiksi atau inkonsisten sehingga pemangku kepentingan ragu-ragu dalam melaksanakan hapus buku atau hapus tagih tersebut.
The Mediator Role of Interaction Anxiety in the Relationship between Social Support Perception and Smartphone Addiction
Authors: Çelik Osman Tayyar , Konan Necdet
Published: March 2019

Preservice teachers prepare for a profession that
requires intense communication and interaction. They are expected to gain
competencies in their profession in this process. These competencies include
the technical knowledge particular to the profession, and communication and
social skills. It is thus important to investigate the factors that affect the
academic and social interaction, the learning environment and the psycho-social
development of university students, and in particular, preservice teachers.
This study aims to investigate the relationship among preservice teachers’
social support perceptions, interaction anxiety and smartphone addiction. The
students from the faculty of education and the students with the pedagogical formation
training in İnönü University during the 2017-2018 academic year constituted the
population of the study and the participants were 496 preservice teachers who
were selected from this population using the random sampling technique.
Hypotheses were developed to investigate the relationship among the research
variables. After testing the hypotheses, the results indicated that the
preservice teachers’ social support perceptions and interaction anxiety
significantly predicts their smartphone addiction, that their social support
perceptions significantly predict their interaction anxiety, and that their
interaction anxiety has a mediator effect on the relationship between their
social support perceptions and smartphone addiction.
Planning a Programme of Pre-authorisation Clinical Trials of Medicines for the Treatment of Chronic Hepatitis C
Authors: Gubenko A. I. , Eremenko N. N.
Published: March 2019

In 2016 the WHO Assembly defined a global strategy to combat viral hepatitis viruses, which seeks to eliminate these infections by 2030. The most important goals of this programme, adopted by 194 countries, are to reduce the incidence of viral hepatitis by 90 % and mortality rates – by 65 % as compared to the levels observed in 2016. Therefore, there is an obvious need for development of medicines for the treatment of chronic hepatitis C. The aim of the present paper was to determine basic approaches to planning pre-authorisation clinical trials for the main groups of medicines for the treatment of chronic hepatitis C. The paper summarises the current trends in the treatment of chronic hepatitis C; it lists medicines with direct antiviral effect that are currently registered in the Russian Federation, as well as interferon-free and interferon-containing regimens for the treatment of this disease. The authors examined the current requirements in force in the Russian Federation, namely: the Federal Law No. 61-FZ «On circulation of medicines» dated April 12, 2010, the Guideline on Evaluation of Medicinal Products, the Clinical Recommendations for Diagnosis and Treatment of Adult Patients with Hepatitis C, as well as recommendations of the European Medicines Agency and the Food and Drug Administration in order to analyse the planning of programmes of pre-authorisation clinical trials of interferon alfa products and direct antivirals.
Optimisation of the Microbial Cell Concentration Procedure in Plague Vaccine Production
Authors: Sharov D. A. , Leshchenko A. A. , Bagin S. V. , Mokhov D. A. , Logvinov S. V. , Krupin V. V. , Ezhov A. V. , Lazykin A. G. , Birjukov V. V.
Published: March 2019

To date, the technology of live plague vaccine production uses a combined method of concentrating microbial cells which consists of three operations with a total duration of 18 hours. The procedure of obtaining concentrate, which is used in the current vaccine production technology, has a number of disadvantages, namely: multiple operations, high energy consumption, long duration, and, as a consequence, low yield of concentrated suspension (0.04 l from 1 l of native culture). The aim of the study was to optimise the procedure of Yersinia pestis ЕV microbial cell concentration using the system for tangential flow microfiltration with the ASF-020 filter support unit. Materials and methods: the vaccine strain used in the study was Yersinia pestis ЕV derived from NIIEG cell line (the strain of the Research Institute of Epidemiology and Hygiene). Submerged cultivation of the native culture was performed using the BIOR-0.25 reactor. The content of live microbial cells was determined by cytorefractometry. Oxidative metabolism was assessed using the chronoamperometric method. Physico-chemical and immunobiological properties of the dry live plague vaccine were assessed according to the monograph FS.3.3.1.0022.15 of the State Pharmacopoeia of the Russian Federation, 14 edition. Results: the equipment’s design features made it possible to carry out membrane filtration of the microbial suspension using the BIOR-0.25 reactor as an intermediate storage unit, thereby excluding three technological stages. The total concentration of microbes in the suspension obtained by the routine and the optimised methods was not less than 120 billion microbial cells/ml. A comparative study of the effect of various hydrodynamic regimes in the working cavities of ASF-009 and ASF020 filter units did not significantly affect the morphometric and physiological properties of microbial cultures. Experimental data helped to determine the process mass balance of membrane filtration. The optimised technology gave 0.17 l yield of the concentrate from 1 l of native culture, and the process duration was reduced to 4 hours. Conclusions: the process of concentrating Y. pestis EV microbial cells during production of plague vaccines was optimised. A comparative study of morphometric and physiological properties of plague microbe cultures that was carried out during their concentration using the optimised technology did not reveal any significant differences as compared to the routine one.
Hemşirelerin Profesyonellik Davranışları Ve Tükenmişlik Düzeyleri
Authors: Can Recep , Hisar Kemal Macit
Published: March 2019

Amaç: Bu çalışma, hemşirelerde
profesyonellik davranışları ve tükenmişlik düzeylerini belirlemek amacıyla
yapılmıştır.

Gereç ve Yöntem: Bu çalışma tanımlayıcı tiptedir. Araştırmanın evrenini bir ilçedeki
kamu sağlık kuruluşlarında görev yapan hemşireler oluşturmuştur. Örnekleme
yöntemi olarak amaçlı örneklem yapılmıştır. Araştırmada veri toplama aracı
olarak üç bölümden oluşan anket formu kullanılmıştır. Anket formunun birinci
bölümünde kişisel bilgi formu, ikinci bölümünde Profesyonel Davranış
Değerlendirme Envanteri (HPDE), üçüncü bölümünde Maslach Tükenmişlik Ölçeği yer
almaktadır.

Bulgular: Hemşirelerin %36’sının klinik servislerde çalıştığı, %59,6’sının
36-45 yaş aralığında ve %78,7’sinin kadın olduğu belirlenmiştir. Hemşirelerin
profesyonellik davranışlarından toplumsal hizmet sunma ve yeterlilik ve sürekli
eğitim boyutları ile duygusal tükenmişlik arasında negatif yönlü, düşük düzeyde
anlamlı ilişki olduğu tespit edilmiştir. Regresyon katsayılarının anlamlılığına
göre profesyonelliğin alt boyutlarından olan yeterlilik ve sürekli eğitim
boyutunun duygusal tükenmişlik üzerinde negatif yönlü anlamlı etkiye sahip olduğu
belirlenmiştir.

Sonuç: Hemşirelerin profesyonellik davranışları düşük ve tükenmişlik
düzeyi ise yüksek olduğu saptanmıştır. Bu sonuçlar doğrultusunda eğitim ve
uygulamaların yapılması önerilmektedir.  
Sivas İlinde Annelerin Emzirmeyi Sonlandırmak İçin Kullanılan Geleneksel Yöntemleri Bilme ve Kullanma Durumlarının İncelenmesi
Authors: Yıldız İlknur , Gölbaşı Zehra
Published: March 2019

Amaç:
Bu çalışma, emzirme deneyimi olan annelerin emzirmeyi sonlandırma sürecinde
kullanılan geleneksel yöntemleri duyma ve kullanma durumlarını belirlemek
amacıyla yapılmıştır.

Gereç ve Yöntem: Tanımlayıcı tipteki
araştırma, Sivas il merkezinde bulunan üç aile sağlığı merkezinde
yürütülmüştür. 241 anne araştırmanın örneklemini oluşturmuştur. Veriler, “Tanıtıcı
Bilgi Formu” ve “Emzirmeyi Sonlandırma Yöntemlerini Belirleme Formu” ile
toplanmış, sayı,
yüzde, ortalama ve standart sapma ile değerlendirilmiştir. 

Bulgular:
Annelerin yaş ortalaması 36.02±8.07 olup, %48.1’i ilkokul mezunu, %93.4’ü
çalışmamakta ve %89.6’sı il merkezinde yaşamaktadır. Emzirmeyi sonlandırma
sürecinde kullanılan yöntemler arasında en fazla bilinen yöntemlerin memelere
salça sürmek (%72.2), biber sürmek (%64.3) ve emzik kullanmak (%50.6) olduğu belirlenmiştir.
Annelerin emzirmeyi sonlandırma sürecinde kullandıkları yöntemlerde ise ilk üç
sırada biberon kullanmak (%44.4), meyve suyu vererek oyalamak (%39.8), emzik
kullanmak (%38.6) gibi yöntemler yer aldığı bulunmuştur.  

Sonuç:
Emzirmeyi sonlandırma sürecinde anneleri duydukları ve kullandıkları
yöntemlerin “memenin görüntüsünü ve tadını olumsuz etkileyecek bazı maddeler
kullanarak çocuğun memeden uzaklaştırılması”, “çocuğun biberon ve emzik gibi
meme yerine geçecek araçlarla ya da bazı besinlerle oyalanması” ve “çocuktan
uzaklaşma” başlıkları altında toplandığı görülmüştür. 
ECONOMICS, POLITICS, LAW: TRENDS AND PROSPECTS Vol.1 March 2019: сб.науч.тр./ OEAPS Inc.; редкол.: Флора Бертран (отв.ред.) [и др.]. - Берлин, Германия : OEAPS Inc., 03. 2019. - 142 С.
Authors: Орлова Валентина Александровна , Мелентьева Оксана Владимировна , Боровая Анна Дмитриевна , Пономарева Ольга Николаевна , Мавлянов Абдыкапар Субанкулович , Оразымбеткызы Айгуль , Кайпбаева Айжан Оразымбетовна , Гензюк Эдуард Ефимович , Кушнир Ольга Николаевна , Кириленко Виктория Сергеевна , Спектор Людмила Александровна
Published: March 2019

The conference is a major international forum for analyzing and discussing trends and approaches in research in the field of economics, politics and law. We provide a platform for discussions on innovative, theoretical and empirical studies of problems in these disciplines. Given the international focus, materials of a comparative nature are especially welcomed.Doctors and candidates of science, scientists, specialists of various profiles and directions, applicants for academic degrees, teachers, graduate students, undergraduates and students are invited to participate in the conference.
A dynamical multi-input/multi-output network formulation for stability analysis in AC microgrids
Authors: Spanias Chrysovalantis , Aristidou Petros , Michaelides Michalis
Published: March 2019

Nowadays, we have witnessed a significant increaseof renewable sources across the existing power grids, as aresult of the undeniable need to mitigate the effects of environmental pollution and assist the economic development of countries around the globe. However, due to the lack of rotational inertia and their intermittent nature, renewables have also increased the severity of the occurring disturbances and instability phenomena, which in turn place a demand for more accurate modeling of the network and the power system components. In this paper, we propose a novel network formulation for AC microgrids that allows the consideration of less conservative conditions for the network, while allowing the adoption of higher order inverter-based generation dynamicsand facilitating the stability analysis and control. In particular, we formulate the network as a dynamical multi-input/multi-output system, which we show is both stable and passive, even if the network’s dynamic and lossy nature is taken into account. We then briefly discuss the opportunities and the advantages offered by the proposed approach and provide useful guidelines for a more accurate modeling of power system components.Finally, we verify the proposed network formulation through a numerical application on the Four Machine Two Area Kundur test system and several simulations on typical Medium Voltage (MV) distribution lines.
FREKUENSI PENCUCIAN YANG BERBEDA TERHADAP KEKUATAN GEL DAN PROTEIN LARUT GARAM SURIMI IKAN MANGGABAI (Glossogobius giuris)
Authors: domili rahyuni
Published: March 2019

The research was aimed to know the effect of different washing frequency on Surimi of Manggabai fish (Glossogobius giuris) wich is gel strength and salt soluble protein. This experiment used experimental method with different washing factor treatment that is 1,2,3, and 4 times leaching and research parameter is gel strength and soluble salt protein of Surimi Manggabai fish (Glossogobius giuris). The research data was processed using a complete randomized design (RAL) analysis. Based on the value of gel strength and salt soluble protein, twice washing as the best treatment for gel strength value is 694.81 gram / cm and salt soluble protein is 13.38%. Keywords: Surimi, frequency of washing, gel strength, salt soluble protein Abstak Penelitian ini bertujuan untuk mengetahui pengaruh frekuensi pencucian yang berbeda pada surimi ikan Manggabai (Glossogobius giuris) terhadap kekuatan gel dan protein larut garam. kekuatan. Penelitian ini menggunakan metode eksperimen dengan perlakuan faktor frekuensi pencucian yang berbeda yaitu 1,2,3, dan 4 kali pencucian dengan parameter uji yaitu kekuatan gel dan protein larut garam surimi ikan Manggabai (Glossogobius giuris). Data penelitian diolah menggunakan analisis ragam rancangan acak lengkap (RAL). Berdasarkan nilai kekuatan gel dan protein larut garam, diperoleh pencucian dua kali sebagai perlakuan terbaik untuk dengan nilai kekuatan gel sebesar 694.81 gram/cm dan protein larut garam sebesar 13,38 %. Kata kunci : Surimi, frekuensi pencucian, kekuatan gel, protein larut garam
Economic Outcomes for Harvesters under the West Coast Groundfish Trawl Catch Share Program: Have Goals and Objectives Been Met?
Authors: Pfeiffer Lisa
Published: March 2019

The West Coast Groundfish Trawl Catch Share Program was designedto achieve multiple economic goals and objectives, including increasingnet benefits, profitability, flexibility, and utilization of harvest allocations.In this article, we leverage seven years of comprehensive costand earnings data to evaluate progress towards these goals with afocus on harvesters. Our assessment shows that five years post-implementation,net benefits to the nation have doubled, and indicators ofproductivity and profitability have increased. The fleet that targetsPacific whiting has seen the largest gains, due in part to increases intotal allowable catch and the elimination of the race-to-fish. However,increased revenues have not been realized to the degree that wasexpected for harvesters targeting non-whiting groundfish, partly dueto lower than predicted consolidation and relatively low quota utilization.Economic outcomes indicate that tradeoffs exist between certainobjectives of the program, specifically between achieving full utilizationand flexibility for harvesters. Results are discussed in the contextof the design and evaluation of catch share programs for diverse, multispeciesfisheries.
Crew in the West Coast Groundfish Catch Share Program: Changes in Compensation and Job Satisfaction
Authors: Steiner Erin
Published: March 2019

Catch share programs can have far-reaching effects on coastal communities and the people that rely on fishing income, including crew members. Analysis of management actions affecting crew wages and well-being is often limited due to a dearth of available data. We examine crew-related outcomes during the first six years of the West Coast Groundfish Trawl Catch Share Program using two unique datasets – a mandatory economic survey and a voluntary social science study. We find that impacts on crew compensation differ from other catch share programs due to prior conditions of the fishery and also vary by the target species within the program. The median number of crew positions per vessel increased slightly, annual crew days decreased, and crew wage as a percentage of revenue was nearly unchanged, even with the introduction of new costs. Median daily crew compensation increased from \$514 per day to \$776 after implementation of catch shares and annual compensation increased from \$33 thousand to \$39 thousand. Many crew members expressed a lack of support for the program and job satisfaction did not rise with increased wages and fewer days at sea, indicating that job satisfaction is likely influenced by more than compensation and effort.
The momentary benefits of positive events for individuals with elevated social anxiety
Authors: Doorley James , Goodman Fallon Rachael , Disabato David , Kashdan Todd Barrett , Weinstein Jennifer S. , Shackman Alexander J.
Published: March 2019

Understanding how individuals with varying levels of social anxiety respond to daily positive events is important. Psychological processes that increase positive emotions are being widely used as strategies to not only enhance well-being but reduce the symptoms and impairment tied to negative emotional dispositions and conditions, including excessive social anxiety. At present, it is unclear whether/how levels of social anxiety impact the psychological benefits derived from momentary positive events. We used ecological momentary assessment (EMA) to examine the impact of trait social anxiety on momentary changes in emotions, sense of belonging, and social approach versus avoidance motivation following positive events in daily life. Over the course of a week, people with elevated social anxiety experienced greater momentary anxiety and social avoidance motivation and lower momentary happiness and sense of belonging on average. Despite these impairments, individuals with elevated social anxiety experienced greater psychological benefits – in the form of less anxiety and motivation to avoid social situations, and a greater sense of belonging– following positive events during the past hour that were ranked as particularly intense. Findings failed to show specificity to social anxiety, with evidence of similar effects for other forms of internalizing psychopathology (general anxiety and depression). These observations detail circumstances in which individuals with social anxiety, and other emotional disturbances, can thrive – creating potentially important targets for intervention.
Reciprocity and alignment: quantifying coupling in dynamic interactions
Authors: Fairhurst Merle Theresa , Dumas Guillaume
Published: March 2019

Recent accounts of social cognition focus on how we do things together suggesting that becoming aligned relies on a reciprocal exchange of information. The next step is to develop richer computational methods that quantify the degree of coupling and describe the nature of the information exchange. We put forward a definition of coupling comparing it to related terminology and detail available computational methods and the level of organisation to which they pertain, presenting them as a hierarchy from weakest to richest forms of coupling. The rationale is that a temporally coherent link between two dynamical systems at the lowest level of organisation sustains mutual adaptation and alignment at the highest level. Postulating that when we do things together, we do so dynamically over time, we argue that to determine and measure instances of true reciprocity in social exchanges is key. Along with this computationally rich definition of coupling, we present challenges for the field to be tackled by a diverse community working towards a dynamic account of social cognition.