bluuebunny/crossref_metadata_2025 huggingface dataset:
Patient-reported outcomes and healthcare resource utilization in systemic lupus erythematosus: Impact of disease activity
Authors: Touma Zahi , Costenbader Karen H. , Hoskin Ben , Atkinson Christian , Bell David , Massey Olivia , Berry Pamela , Karyekar Chetan S.
Published: May 2022

Background Limited real-world data exists on clinical outcomes in systemic lupus erythematosus (SLE) patients by SLE Disease Activity Index 2000 (SLEDAI-2K). We aimed to examine the association between SLEDAI-2K score and clinical, humanistic and economic outcomes in patients with SLE.MethodsRheumatologists from the United States of America and Europe provided real-world demographic, clinical, and healthcare resource utilization (HCRU) data for SLE patients. Patients provided self-reported outcome data, capturing their general health status using the EuroQol 5-dimension 3-level questionnaire (EQ-5D-3L), health-related quality of life using the Functional Assessment of Chronic Illness Therapy (FACIT) and work productivity using the Work Productivity and Activity Impairment questionnaire (WPAI). Low disease activity was defined as SLEDAI‑2K score ≤4 and ≤7.5mg/day glucocorticoids; patients not meeting these criteria were considered to have “higher” active disease. Data were compared between patients with low and higher disease activity. Logistic regression estimated a propensity score for SLE based on demographic and clinical characteristics. Propensity score matched analyses compared HCRU, patient-reported outcomes, income loss and treatment satisfaction in patients with low disease activity versus higher active disease.ResultsData from 296 physicians reporting on 730 patients (46 low disease activity, 684 higher active disease), and from 377 patients’ self-reported questionnaires (24 low disease activity, 353 higher active disease) were analyzed. (Flaring in the previous 12 months was 2.6‑fold more common among patients with higher versus low active disease.) EQ 5D‑3L utility index was 0.79 and 0.88 and FACIT-Fatigue scores were 34.78 and 39.79 in low versus higher active disease patients, respectively, indicating better health and less fatigue, among patients with low versus higher active disease. Absenteeism, presenteeism, overall work impairment, and total activity impairment were 47-, 2-, 2-.6- and 1–5-fold greater in patients with higher versus low disease activity. In the previous 12 months there were 28% more healthcare consultations and 3.4‑fold more patients hospitalized in patients with higher versus low disease activity.ConclusionCompared to SLE patients with higher active disease, patients with low disease activity experienced better health status, lower HCRU. less fatigue, and lower work productivity impairment, with work absenteeism being substantially lower in these patients.
Solar Energetic Particle “Ground-Level Enhancements” and the Solar Cycle
Authors: Owens Mathew J. , Barnard Luke A. , Pope Benjamin J. S. , Asvestari Elenna , Lockwood Mike , Usoskin Ilya
Published: May 2022

Severe geomagnetic storms appear to be ordered by the solar cycle in a number of ways: They occur more frequently close to solar maximum and declining phase, are more common in larger solar cycles and show different patterns of occurrence in odd-and even-numbered solar cycles. Our knowledge of the most extreme space weather events, however, comes from the spikes in cosmogenic-isotope (14C, 10Be and 36Cl) records that are attributed to significantly larger solar energetic particle (SEP) events than have been observed during the space age. Despite both storms and SEPs being driven by solar eruptive phenomena, the event-by-event correspondence between extreme storms and extreme SEPs is low. Thus it should not be assumed a priori that the solar cycle patterns found for storms also hold for SEPs and the cosmogenic-isotope events. In this study we investigate the solar cycle trends in the timing and magnitude of the 67 SEP “ground-level enhancements” (GLEs) recorded by neutron monitors since the mid 1950s. Using a number of models of GLE occurrence probability, we show that GLEs are around a factor four more likely around solar maximum than around solar minimum, and that they preferentially occur earlier in even-numbered solar cycles than in odd-numbered cycles. There are insufficient data to conclusively determine whether larger solar cycles produce more GLEs. Implications for putative space-weather events in the cosmogenic-isotope records are discussed. We find that GLEs tend to cluster within a few tens of days, likely due
Establishment and Evaluation of an Early Prediction Model of Hepatorenal Syndrome in Patients with Decompensated Hepatitis B Cirrhosis
Authors: Wang Shouhao , Zhou Zhewen , Xu Chengan , Chen Hanzhu , Ren Wenya , Yang Xingdi , Yin Qiaoqiao , Zheng Wei , Pan Hongying
Published: May 2022

Background and aimIn China, hepatorenal syndrome is a serious complication in the decompensated stage of hepatitis B cirrhosis, which requires early clinical intervention, so the early diagnosis of hepatorenal syndrome is crucial. This study establishes a new predictive model based on serum biomarkers for the early diagnosis of hepatorenal syndrome.MethodsPatients with decompensated hepatitis B cirrhosis who met the inclusion and exclusion criteria were retrospectively enrolled. Patients were randomly assigned to the training dataset and validation dataset at a 7:3 ratio. Univariate and multivariate logistic regression analyses were used to screen the risk factors for hepatorenal syndrome. On this basis, a model was established and verified.ResultsThis study included 255 patients with decompensated hepatitis B cirrhosis, including 184 in the training group and 71 in the validation group. The multivariate logistic regression model was established in the training group and verified in the validation group. Logistic regression showed that hemoglobin (OR 0.938, 95% CI 0.908-0.969), total bilirubin (OR 1.014, 95% CI 1.006-1.019) and creatinine (OR 1.079, 95% CI 1.043-1.117) were independent risk factors for hepatorenal syndrome (P < 0.05). These were used to establish the model. In the training group and the validation group, the area under the ROC curve (AUC) of the nomogram for the diagnosis of liver fibrosis was 0.968 and 0.980.ConclusionThe three serum biomarkers hemoglobin, total bilirubin and creatinine can be used as independent early predictors of hepatorenal syndrome in patients with decompensated hepatitis B cirrhosis.
Successful treatment of granulomatosis with polyangiitis using tocilizumab combined with glucocorticoids: A case report and literature review
Authors: Tang Pengfang , Xu Longchuang , Hong Wenting , Shi Hongying
Published: May 2022

Background: Tocilizumab is a humanized monoclonal antibody against the interleukin-6 (IL-6) receptor that is commonly used to treat large vessel vasculitis and antineutrophil cytoplasmic antibody (ANCA)-related small vessel vasculitis (AAV). However, tocilizumab in combination with hormones for successfully treating granulomatosis with polyangiitis (GPA) has rarely been reported.Case presentation: Here, we report a 40-year-old male patient who suffered GPA for 4 years. He was treated with multiple rounds of drugs, including cyclophosphamide (CTX), Tripterygium wilfordii (TW), mycophenolate mofetil (MMF) and belimumab, with no improvement. In addition, he exhibited persistently high IL-6 levels. After tocilizumab treatment, his symptoms improved, and his inflammatory marker levels returned to normal.Conclusions: Tocilizumab may be effective for treating GPA.
Exploration and evaluation of design quality through floor plan layout (FPLs) of an existing design space using the ARLE GPS tool. Case study
Authors: Martins Daniel das Neves
Published: May 2022

The ARLE GPS computational tool sets up a simple mathematical representation of a high-fidelity simulator and explorer, through its physics-biology model. Which establishes an input-output relationship of the input geometric data of the spatial planning of the floor plan layout (FPL) of a house, with the output data of the physical model that quantifies and qualifies the candidate solution, in an analogy with the functional physical performance of the house, making it possible to simulate, evaluate and optimize the geometric solution of the FPL. And it provides the data for the biological model to genetically describe the artifact of the house, to make available the relevant information of the components of the FPL structure. Specified by the genes form, function, topology, and space. This meta-model thus enables the construction, exploration, and evaluation of design spaces. It aims to make available to architects: to know, compare, and transcribe genetic information from these artifacts, for the development of innovative artifacts through creative designs. The exploration of an existing design space, through its evaluation, allows the transcription of the mined data, extracted from high performance projects, to compose new and better designs. It also enables the establishment of solution approximation functions, defined by means of predictive response surfaces, which allow insights into the FPL design solution domain, and predict the performance of candidate designs.
Are We Going to Survive Transplant During the Covid-19 Outbreak: Case Report
Authors: ALTAS OZGE , AKSUT MEHMET , KIRALI KAAN
Published: May 2022

IntroductionOn March 10, the first case of coronavirus disease 2019 (COVID-19) was reported in Turkey; in the meantime, over 95 million confirmed cases with more than 2 million deaths have been reported worldwide. Case PresentationAfter the identification of first COVID-19 (+) patient, our center conducted the management of selection and treatment of candidates and continued to perform cardiac transplantations. We herein present two cases after determination of patient zero in Turkey in order to highlight clinical implications by describing our clinic principle in the ethical knowledge of ISHLT COVID-19 Task force statement regarding heart transplantation (HTx).ConclusionsCOVID-19 creates a challenge on donor selection and post-transplant management and immunosuppressive therapy. And, a question arises about continuing HTx due to risk of immunosuppressive therapy, as well as exposure during hospitalization.
Emotional Problems, Dark Personality, Sexting and Grooming in Adolescents: the role of Gender and Age
Authors: Resett Santiago , González Caino Pablo , Mesurado Belén
Published: May 2022

The present study aimed to study if emotional problems (depression and anxiety) and Dark Personality were predictors of sexting and grooming, and if this behavior differs by gender and age. A sample of 728 adolescents between 11 and 18 years of age (38% male) from three private high schools located in Buenos Aires and Paraná, Argentina, was drawn. They completed a Sexting questionnaire, the Questionnaire for Online Sexual Solicitation and Interaction of Minors with Adults for grooming behavior, Rosenberg Scale of Psychosomatic Symptoms, the Kovacs Depression Inventory for Children and the Dirty Dozen for dark personality traits. Results showed that 12% of adolescents admitted having carried out a sexting behavior. Sending written messages of a sexual nature (11%) and photos (10%) were the most prevalent ways, followed by videos (4%), but no differences were detected according to gender. Significant predictors of sexting and the size of its explained variance ranged by gender (R² = 47% for females and R² = 12% for men, respectively). In the case of females, older age and psychopathy were the significant predictors. In the case of males, less anxiety was the significant predictors. A structural model explained a variance of 6% for sexting and 21% for grooming, indicating that there was no inavariance, according to gender. Linear regressions to predict grooming from sexting also suggested this relationship was moderated by gender.
Quantification and health risk assessment of nitrate in southern districts of Tehran, Iran
Authors: Kalteh Safa , Hamidi Farshad , Nasab Mahdi Ahmadi , Gharibdoosti Narges Mohseni , Ghalhari Mohammad Rezvani , Parvizishad Mina , Mahvi Amir Hossein
Published: May 2022

Nitrate is a common contaminant of drinking water. Due to its adverse health effects, this study aimed to determine nitrate levels in six southern districts of Tehran. A total of 148 samples were taken from tap waters. In 84.46% (n = 125) of the samples, the nitrate concentration was below national and WHO limits (50 mg/L); however, 15.54% (n = 23) were in violation of the criteria. The total mean concentration of nitrate was 36.15 mg/L (±14.74) ranging from 4.52 to 80.83 mg/L. The overall hazard quotient (HQ) for age groups were ordered as Children (1.71) > Infants (1.24) > Teenagers (1.2) > Adults (0.96). In all districts, the HQ values for infants and children groups were greater than 1, indicating potential adverse health risks. In teenagers age group, only the HQ estimations of districts 10 (HQ = 0.93) and 11 (HQ = 0.74) were lower than 1 and in adults age group, the estimated HQ values for districts were lower than 1 with the exception for district 19 (HQ = 1.19). The sensitivity analysis (SA) showed that nitrate content plays a major role in the value of the assessed risk.
DEMOCRACIA E EXCEÇÃO NA OBRA DE GIORGIO AGAMBEN
Authors: Bezerra Josinaldo Alves , Medeiros Gilmara Joane Macêdo de , Lima Thiago Arruda Queiroz
Published: May 2022

MesmocomofimdaSegundaGuerraMundial,temseverificado,nasdemocracias contemporâneas, a perpetuação de um tipo de governo que teve seu ápice durante esse cenário histórico: a Exceção. O que se observa nos dias hodiernos é que se vive um Estado de Exceção dentro da própria legalidade, visto a desigualdade dos cidadãos frente ao Judiciário e a relevância cada vez mais crescente de uma figura autoritária. Para isso, pretende-se estudar melhor o conceito através da obra do filósofo italiano Giorgio Agamben, por meio do seu livro Estado de Exceção (Homo Sacer II,I). Para melhor compreensão do termo, adota-se como metodologia a revisão bibliográfica de autores que tratam a respeito do totalitarismo – tais como Hannah Arendt, Ian Kershaw e Jason Stanley –, além de obras cinematográficas, a fim de contribuir algumas relações pertinentes às obras literárias selecionadas como marco teórico deste trabalho, com o fito de perceber as nuances e particularidades desse tipo de governo ao longo da História e como isso se reverbera na contemporaneidade.
Az inak elzsírosodása – tendolipidosis
Authors: Józsa László
Published: May 2022

A szerző 891 rupturált, és 445 kontrollín mikroszkópos és elektronmikroszkópos vizsgálatával többféle elzsírosodást állapított meg. A finomcseppes lipidosis, a tendoatheromatosis leggyakoribbak, de nem befolyásolják az inak mechanikai tulajdonságait. A tendolipomatosis jelentősen csökkenti az ín szakítószilárdságát, és gyakran (a quadriceps ínon 40%-ban, a többi ínon 0–9%-ban) eredményez ínszakadást. A génmutáción alapuló ritka veleszületett betegségekben diffúz, vagy tumorszerű lipophag sejtszaporulat következik be, amely szövetileg jól elkülöníthető a tendolipidosisoktól.
Gyakori diagnosztikus hibák és szövődmények a kézsebészetben : I. Diagnosztikus tévedések. Szövődmények a kezelés során (Irodalmi áttekintés)
Authors: Bíró Vilmos
Published: May 2022

A szerző irodalmi értékelő munkájában összefoglalta a kézsebészetben fellelhető gyakori diagnosztikus tévedéseket és a kezelés során kialakult szövődményeket. Munkáját három fő részre osztotta: jelen, első részben a kórismézési hibákat és a kezelések komplikációit tárgyalja. A tanulmány második és harmadik részében a kézsérülések okozta szövődményekkel kíván foglalkozni. A jelenlegi munkában értékeli a megkésett diagnózis elkerülésének módjait: a gondos anamnézis felvételt, a kéz gyors vizsgálatának módszereit, beleértve a nem kooperáló betegek kezének vizsgálatát és az elnézett esetek felismerésének lehetőségeit. A kezelések során kialakult leggyakoribb komplikációknál megemlíti a sebzárás, a lágyrész sérülések, a sebkötözések és a kézen végzett egyéb eljárások okozta károsodások felismerését és kezelését. Dolgozata végén az érdeklődők számára bőséges irodalomjegyzéket csatolt.
Maradandó károsodás a kézen : Egy nem felismert idegsérülés kálváriája... (Esetismertetés)
Authors: Renner Antal
Published: May 2022

A nervus medianus tompa sérülése nem tartozik a gyakori sérülések közé a felső végtagon. Panaszokat leggyakrabban alagút szindrómák részeként okoz. Fontos a proximalis (magas) és a distalis nervus medianus károsodás tünetei közötti különbség, valamint a sebészi anatómia ismerete ahhoz, hogy ritkán előforduló sérülések helyes diagnózisához jussunk. Az alkar proximalis harmadában lévő sérüléseket már a magas nervus medianus sérülések közé soroljuk!
Os capitatumban elhelyezkedő osteoid osteoma okozta csuklótáji fájdalom (Esetismertetés)
Authors: Fetter Gábor , Csete Károly , Simonka János Aurél , Böröndy János , Hamar Sándor , Varga Endre
Published: May 2022

A csuklótáji fájdalom, amely a mindennapi életet jelentős mértékben megnehezítheti, sokféle okra vezethető vissza. A túlerőltetés, valamint a trauma, a fájdalom a leggyakoribb okozója. Számos esetben degeneratív okok állnak a panaszok hátterében és kis százalékban neoplastikus folyamat is lehet a fájdalom okozója. Az esetismertetésben szereplő beteg panaszait a daganatos betegségek egy ritka formája okozta. A kézen előforduló daganatoknak csak kis százalékát teszik ki a csontdaganatok. Ezen belül az osteoid osteoma még kisebb százalékban szerepel, valamint a ritkaságot tovább fokozza, hogy az os capitatumban való előfordulásáról az elmúlt években nem tettek említést.
Az idegtranszplantációk késői eredményei a felső végtagon és a kézen
Authors: Renner Antal , Cserkuti Ferenc , Rutek Zsuzsanna , Szentirmai Annamária
Published: May 2022

A perifériás idegsérüléseknél – különösen a kézen – az optimális eredményt az elsődleges, illetve a korai halasztott sürgősség keretében, korszerű technikával elvégzett idegvarrattól várhatjuk. Műtéttechnikai szempontból azonban az interfascicularis graft eredményei kedvezőbbek, mint a kompromisszumok árán elvégzett epineuralis idegvarraté. A 2 cm-nél kisebb ideg graft transzplantációja optimális körülmények között azonos értékű a jó primer varrattal. A 2 cm-nél nagyobb ideg graft alkalmazása, továbbá a sérülés jellegéből adódó negatív lokális tényezők halmozódása fokozatosan rontja a késői eredményeket. A végeredményt döntően befolyásolja a beteg életkora és a sérüléstől a műtétig eltelt idő. A retrospektív vizsgálat célja annak megállapítása, hogy az idegtranszplantációs betegeknél a sérülés jellege, a sérüléstől eltelt idő, a műtéti terület vérellátása, a transzplantátum mérete, az alkalmazott kezelési módszer hogyan befolyásolták a késői eredményeket.
Fülkagyló deformitás megelőzése rekonstrukciós technikákkal
Authors: Szűcs Attila , Péter Zoltán , Kiss Rebeka , Tóth Andrea , Fekete Attila
Published: May 2022

A fülkagylót infiltráló tumorok eltávolítását követő rekonstrukció célja az ellenoldalival megegyező alakú és nagyságú fülkagyló kialakítása. Munkánk során több alkalommal találkoztunk olyan deformált fülkagylóval, amelynél a tumor eltávolítása után a rekonstrukciót nem, vagy nem megfelelő módon végezték el. Klinikánkon a porcot, illetve az ellenoldali bőrt is infiltráló tumorok eltávolítása után a helyreállító műtétet porc grafttal és lebenyforgatásos bőrpótlással végeztük el. Az ismertetett esetek az intézetünkben kezelt betegek közül egy-egy különböző lokalizációt érintő esetben mutatják be a rekonstrukciós lehetőségeket.
IMMUNOSTIMULANT POTENTIAL OF OYSTER MUSHROOM NUGGET (Pleourotus ostreatus)
Authors:   Universitas Surabaya, Deasy Rosita Dewi Ardhia , Pamula Mukti Yayon ,   Universitas Surabaya
Published: May 2022

Oyster mushrooms are widely known as having high beta glucan content. Beta glucan is a water insoluble fiber that indicates an immunomodulator with increasing the activity of NK cells in the bloodstream which provides immune effect. Oyster mushroom nuggets are processed oyster mushrooms that can be proven containing the highest beta glucans. This study aims to observe the immunostimulant potential of oyster mushroom nuggets in BALB/c mice by analyzing its white blood cell profile, spleen and liver histopathology. The research method is conducted through orbital sinus of the rat's eye using a microhematocrit to count total leukocytes, lymphocytes, and granulocytes with the Delayed Type Hypersensitivity test. The 18mg/kg body weight oyster mushroom nugget can increase lymphocytes cells 7.2 ± 1.22 103/µl. It is significantly different from control group. Immunostimulatory activity also was proven with the widening of the white pulp of the spleen with the growth of young lymphocytes after being given oyster mushroom nuggets of 18 mg/kg body weight.
PENYUSUNAN TINDAKAN PERBAIKAN PADA PROSES PENGENDALIAN CACAT PRODUK ROTI MANIS DI FLORINA BAKERY, KABUPATEN PASER, KALIMANTAN TIMUR
Authors:   Universitas Brawijaya, Musanta Ivan , Mahar Maligan Jaya ,   Universitas Brawijaya
Published: May 2022

Florina Bakery merupakan produsen roti berskala UMKM yang berlokasi di Kabupaten Paser, Provinsi Kalimantan Timur. Florina Bakery berkomitmen memenuhi permintaan pasar yang bertumbuh dengan roti yang bermutu. Penelitian ini ditujukan untuk membantu menganalisis produk cacat yang terjadi pada produksi roti manis di Florina Bakery. Analisis produk cacat menggunakan metode statistical quality control, meliputi: pendataan dengan check sheet, pembuatan diagram Pareto, pembuatan peta kendali, analisis diagram sebab-akibat, dan perencanaan tindakan perbaikan. Pengamatan pendahuluan menemukan terbentuknya produk cacat berupa: kulit terkelupas, isian keluar, penyok, dan bentuk tidak sesuai model. Diagram Pareto dan peta kendali menunjukkan: (1) besar potensial masalah cacat kulit terkelupas (65.36%), cacat isian keluar (22.96%), cacat bentuk (6.24%), dan cacat penyok (5.44%); (2) dan proses produksi roti manis belum terkendali. Rancangan tindakan perbaikan kualitas untuk Florina Bakery berdasarkan diagram sebab akibat, yaitu: peningkatan keterampilan pegawai dalam memproduksi roti, pembuatan SOP, dan menunjuk pengawas untuk mengontrol kegiatan produksi.
The challenges of seasonal adjustment for the Current Employment Statistics survey during the COVID-19 pandemic
Authors: Hudson Nicole , Jeannine Jeannine , Kropf Jurgen
Published: May 2022

For its seasonally adjusted data, the Bureau of Labor Statistics (BLS) seeks to remove all fluctuations that are caused by the yearly cycle of seasons. The coronavirus 2019 pandemic posed a challenge to this task, because its effect was strong, across the entire economy, and lasted for at least several months. To ensure that the effects of the pandemic were not being incorporated into the seasonal adjustment factors, the Current Employment Statistics program took additional actions such as splitting the seasonal adjustment into two runs (prepandemic and postpandemic) and incorporating additional types of outliers into its models.
Non-Woven Tissues as Novel Cosmetic Carriers for a Green Beauty
Authors:   R&D Unit, Academy of History of Healthcare Art, Rome, Italy and Department of Dermatology, China Medical Q University, Shenyang, China, Morganti Pierfrancesco , Morganti Gianluca ,   ISCD Nanoscience Center, Rome, Italy, Coltelli Maria Beatrice ,   Department of Civil and Industrial Engineering, University of Pisa, Pisa, Italy, Yudin Wladimir E ,   Institute of Macromolecular Compounds, Russian Academy of Science, Saint Petersburg, Russia, Chen Hong-Duo ,   Department of Dermatology, the First Hospital of China Medical University, Key Lab of Immunodermatology, National Health Commission, Ministry of Education, Shenyang, China, Gagliardini Alessandro ,   R&D Unit, Texol Srl, Alanno (Pescara), Italy
Published: May 2022

Approximately 75% of textile waste is generated annually worldwide, as there is a dearth of viable recycling strategies. It has been estimated that textile industries can be responsible for approximately 20% of global water pollution. As a consequence, if not properly managed, the cost of waste management of textile waste will be trillions of dollars annually. Moreover, the generated wastes are detrimental to the environment and public health. On the other hand, there is a possibility that the majority of the waste can be recycled to obtain, for example, natural polysaccharides that can be used to produce biodegradable tissues, films, and goods. These innovative tissues, constituted by chitin nanofibrils (CN) complexed with nanolignin (LG) bound to natural polysaccharide-based polymers, may be used as innovative cosmetic green carriers and novel biodegradable food packaging in line with the consumers requests. Consumers, in fact, are looking for biodegradable apparel, footwear, and natural cosmetics for the betterment of health and the environment, and thus, there is a demand for green cosmetics.
Historia Ambiental de América Latina. Enfoques, procedimientos y cotidianidades
Authors: Báez Ponce Mariana , Barajas Alcalá Alma Guadalupe , Berry Michelle Kathleen , Cariño Olvera Martha Micheline , Carlón Allende Teodoro , Castillo Galindo Sofia , Cerón González Axel , Chant Elizabeth Claire , Cuvi José Nicolás , de Carvalho Cabral Diogo , De los Reyes Patiño Reynaldo , Dobler Morales Carlos Enrique , Dutra e Silva Sandro , Favila Vázquez Mariana , Fernandes Valdir , Fernández de Castro Martínez Gonzalo , Fernández Repetto Francisco Javier , Franch Pardo Iván , Gándara Chacana Natalia Lorena , Garnero Gabriel , Garza Merodio Gustavo Gerardo , Gómez López Francisco , Guarez Fabiana Carla , Gutiérrez Núñez Netzahualcóyotl Luis , Leal León Claudia María , Macías Vázquez José Luis , Manríquez Bucio Yurixhi , Méndez Rojas Diana Alejandra , Mendoza Cantú Manuel Eduardo , Molano Camargo Frank , Monteforte Cariño Ananda Michelle , Morales Thor Edmundo , Moreno-Casasola Barceló Patricia , Moreno Terrazas Troyo René , Nieves Rivera Jorge , Olivares Martínez Luis Daniel , Ortega Santos Antonio , Pereira de Oliveira Gabriel , Radding Cinthya , Ribeiro de Oliveira Rogério , Salazar Vélez Adriana , Suárez Santiago Zuan Sofía , Sunyer Martín Pere , van 't Hooft Anuschka Johanna Maria , Vargas Palestina Ernesto , Vasques Vital André , Vázquez Castro Gabriel , Vázquez Solís Valente , Wakild Emily Lynn , Solís Castillo Berenice , Lefebvre Karine Annick Thérèse
Published: May 2022

"Debido a sus características interdisciplinarias y transdiciplinarias, el campo de la historia ambiental involucra una amplia gama de herramientas teórico-conceptuales y metodológicas, que contribuyen a responder preguntas o plantear problematizaciones sobre los cambios ecológicos y geográficos en el pasado. Por tanto, el panorama de análisis y aplicación es abundante y complejo, pero no por ello deja de ser fascinante y digno de compartirse. Con el libro Historia ambiental de América Latina. Enfoques, procedimientos y cotidianidades, especialistas de diversas procedencias, pretenden mostrar las distintas formas de aproximación a este campo emergente. La compilación contenida muestra miradas variopintas y abordajes que, si bien son interdisciplinarios y transdisciplinarios, aportan desde campos específicos muy diversos, como la geografía, la historia, la arqueología, la ecología, la economía, la agronomía o el arte. También revela que se puede escudriñar el pasado desde un archivo histórico, desde los anillos de crecimiento de un árbol, desde la carta de un inmigrante, desde una película, practicando senderismo o pedaleando en bicicleta. En la diversidad de formaciones de las autorías está también la posible riqueza en la propuesta del libro."
La reivindicación del papel femenino en Los recuerdos del porvenir de Elena Garro
Authors: Eissa Osorio Julia Isabel
Published: May 2022

Este trabajo tiene como objetivo el análisis de la reivindicación del papel femenino en la novela Los recuerdos del porvenir (1963) de Elena Garro (1916-1998), ya que la escritora hace una revisión del lugar que ha ocupado la mujer en la historia y la sociedad mexicanas, mostrando los numerosos conflictos relacionados con su posición social, la educación recibida, los estereotipos impuestos, entre otros. No obstante, la autora, al mismo tiempo, trata de ir más allá de la simple crítica y propone una nueva visión para las problemáticas de sus personajes femeninos, ya sea mediante la innovación en las técnicas narrativas (inversión del tiempo, nuevos espacios, utilización de un narrador femenino), o al hacer más obvios los roles impuestos por la sociedad a las mujeres, para mostrar la ausencia de una voluntad propia o la carencia de un libre albedrío en los personajes femeninos. Todo lo anterior con la finalidad de observar la construcción del papel de la mujer en los diversos roles y sectores de la sociedad mexicana ya sea como hija, madre, esposa, amante, prostituta, etcétera; y a través de las diferentes épocas de nuestro país, propiciando una reflexión en el lector sobre los estereotipos femeninos en la sociedad mexicana actual.
El prosaísmo de la modernidad y la prosa novelística a través del ejemplo de A Tale of Two Cities de Charles Dickens
Authors: Saucedo Dimas Rocío
Published: May 2022

Este artículo propone que el fenómeno de la prosa y, más específicamente, el de prosa novelística como forma literaria moderna y sus posibilidades de uso (affordances) guarda una relación con la noción de prosaísmo, entendida como un espectro de experiencias derivadas de las condiciones de vida producidas por la modernidad en Occidente. Dentro de este espectro de experiencias destacan las tensiones entre individuo y colectividad, especialmente la colectividad en la forma de multitudes anónimas en un entorno urbano. Así pues, primeramente se aborda la cuestión del prosaísmo moderno en relación con la prosa literaria. A continuación, se lleva a cabo una revisión de algunas posturas teórico-críticas relacionadas con las posibilidades de uso de la novela que le han permitido a ésta dramatizar la posición contradictoria del individuo liberal y evocar la forma de su subjetividad a través de recursos como la caracterización, el estilo libre indirecto, la focalización, entre otros. Finalmente, se ofrece una lectura del personaje Sydney Carton de A Tale of Two Cities en su relación nocional con el modelo de individuo.
Virtual Valet
Authors: Mahavarkar Jait , Nirmale Siddhi , Kolte Pratiksha
Published: May 2022

Abstract: Virtual Valet is an image processing technology which is used to retrieve the registered number of vehicles from its number plate to identify the vehicle. The main objective is to design an efficient vehicle identification system with the help of its number plate. This system will help in reducing crime, it will help in improving road safety, deterring terrorism. It can be implemented in automatic parking systems, border control. It is useful to detect the stolen cars. This app is also useful in traffic management. It can be used by various police forces and by electronic toll collection. Firstly, the system will ask for the vehicle’s image. After that the region of interest that is number plate is extracted using image segmentation in an image. For character recognition we have used the optical character recognition technique. Optical character recognition is the last step in vehicle number plate detection. After this the resulting data will be used to compare with the database so that we can get specific information like the owner’s name, registration number, address etc. Keywords: (OCR)Optical Character Recognition, Pytesseract, OpenCV, Django
Customer Perception On E-Banking Services of Public and Private Sector Banks in Hyderabad Region
Authors: Lakshmi Papunuka , R Dr. Thamilselvan.
Published: May 2022

Abstract: E-Banking is the use of electronic means in banker-customer and banker-company interactions and internal banking operations to simplify and improve banking services. "Paperless, faceless, cashless" is the recognized role and motto of the cashless economy. Various types of electronic payments are available as part of the promotion of cashless and paperless transactions and the transition of the economy to a cashless society and economy. Various types of electronic payment systems include electronic banking, debit cards, credit cards and electronic wallets. Today, almost all banks are adopting ICT as a means of improving the quality of service of their banking services. Attempts have been made to evaluate the services provided by banks through electronic banking services. Electronic banking services offer a lot of convenience, customer orientation, enhanced quality of service and cost efficiency. We used a structured survey to collect relevant data from our customers. This report examines customer perception of electronic banking services provided by public and private banks in the Hyderabad region. The study sample size is 102. Data is collected from both primary and secondary information. This report uses non-stochastic sampling techniques and the most appropriate sampling method is used for the survey. Keywords: E-banking, Services, Customer satisfaction, Perception
Big Data Analytics in Cloud Computing for Scientific Analytics
Authors: Kushwaha Ashok , Acharya Dr. Kalyan
Published: May 2022

Abstract: Big data analytics in healthcare is evolving into a promising field for providing insight from very large data sets and improving outcomes while reducing costs. The paper describes the nascent field of big data analytics in healthcare, discusses the benefits, outlines an architectural framework and methodology, describes examples reported in the literature, briefly discusses the challenges, and offers conclusions. Keywords: Big data, Analytics, Hadoop, Healthcare, Framework, Methodology.
Ginger Processing and It’s Value Addition
Authors: Nayak Avijeet , Pradhan Debendra , Nayak Dibyadarshan , Swain Dr. Satyananda , Mohanty Prof. Gayatri
Published: May 2022

Abstract: Ginger (Zingiber officinale) is a blooming plant whose rhizome, ginger root, or ginger, is generally utilized as a flavor and a people medication. Ginger is stacked with cell reinforcements, intensifies that forestall pressure and harm to your body's DNA. They might assist your body with warding off persistent sicknesses like hypertension, coronary illness, and infections of the lungs, in addition, to advancing solid maturing. Specialists suggest consuming a limit of 3-4 grams of ginger concentrates each day. Assuming that you're pregnant, don't consume more than 1 gram of ginger concentrate each day. Ginger isn't suggested for youngsters younger than 2. The main put-down the account of ginger comes from the Analects of Confucius, written in China during the Warring States period (475 - 221 BC). However it is filled in numerous regions across the globe, ginger is "among the earliest recorded flavors to be developed and traded from southwest India". Ginger is a significant zest harvest and India is one of the main makers and exporters of ginger in the world. Ginger is generally utilized all over the planet in food as a zest both in new and dried structures which adds flavor to the feast by making a fiery sharp taste. The substance parts of the ginger rhizome change extensively contingent upon the area of development and postharvest medicines. Ginger contains polyphenol mixtures, for example, gingerol and its subsidiaries like zingiberene, bisabolene, camphene, geranial, linalool, borneol, and oleoresin (blend of unstable oils and sap) that records for its trademark fragrance and helpful properties. New gingers is transient and are ruined due to inappropriate dealing with, development of deterioration microorganisms, vulnerability to rhizome decay, withering and growing, the activity of normally happening compounds, substance responses, and primary changes during capacity. Remembering the low time span of usability of new ginger and lacking office for their presentday stockpiling prompting trouble deal, esteem expansion could be a practical elective which will get profitable cost to the producers. The current situation, dietary significance, postharvest the board, esteem added items of ginger have been talked about exhaustively in the survey. Keywords: Zingiber officinale, rhizome, hypertension, coronary illness.
COVID-19 PANDEMİ SÜRECİNİN SAĞLIK ÇALIŞANLARININ MÜZİK BEĞENİLERİ ÜZERİNDEKİ ETKİLERİ
Authors: ŞEN Mehmet Emin , KAYABAŞ Hilal
Published: May 2022

İçinde bulunduğumuz Covid-19 pandemi sürecinin dünya çapında başta sağlık olmak üzere siyasal, ekonomik ve sosyal alanlarda yıkıcı etkileri olduğu şüphe götürmez bir gerçekliktir. Bu salgına karşı en ön cephede savaş verenlerin başında kuşkusuz sağlık çalışanları gelmektedir.

Toplumun her kesiminin derinden etkilendiği ve iki yılı aşkın süredir salgınla mücadeledeki bu süreçte, ön saflarda görev yapan sağlık çalışanları toplumsal yapıda en çok etkilenen grup olarak karşımıza çıkmaktadır. Salgın sürecinin sağlık çalışanlarının müzik beğenilerine etkilerinin araştırıldığı İnönü Üniversitesi Turgut Özal Tıp Merkezi doktor ve hemşireleri ile yapılan bu çalışma, durum tespiti yapmaya yönelik olup betimsel bir özellik sergilemektedir. Araştırmada, kişisel görüşmeler ve bunun yanı sıra ulaşılabilen 56 örnekleme yarı yapılandırılmış anket uygulanarak konuya yönelik daha kapsamlı bir görüş elde edilmeye çalışılmıştır. Araştırma sonuçlarından birkaçı sıralanacak olursa: Sağlık çalışanlarının büyük bir bölümünün bu süreçte duygusal olarak etkilendiği, işitsel dünyasının ve müzik beğenilerinin değiştiği elde edilen bulgular arasındadır.
CRYOGLOBULINEMIC VASCULITIS: LITERATURE REVIEW AND CLINICAL CASE
Authors:   Vitebsk State Order of Peoples' Friendship Medical University, Palhuyeva H.Y. , Makarenko E.V. ,   Vitebsk State Order of Peoples' Friendship Medical University, Lahutchau V.V. ,   Vitebsk State Order of Peoples' Friendship Medical University
Published: May 2022

The purpose of this work was to analyze literature sources on the diagnosis and treatment of cryoglobulinemic vasculitis with the demonstration of our own data. Cryoglobulinemic vasculitis (CV) is a difficult and rare diagnosis not only for a physician, but also for a rheumatologist. The disease has polymorphic clinical manifestations and can debut with lesions of various organs and systems. Additional difficulties in the diagnosis of the disease are created by ambiguous laboratory research results. CV is often associated with lymphoproliferative diseases such as diffuse large B-cell lymphoma or non-Hodgkin’s lymphoma, autoimmune and infectious diseases. Viral hepatitis C is the most common underlying cause of CV and makes up approximately 80% of all cases. In case when the etiological factor is not established, the term «idiopathic» or «essential» CV is used. For the diagnosis of CV, classification criteria are proposed, including the results of the questionnaire, clinical manifestations and laboratory research data. The principles of treating patients with CV are determined by the etiopathogenetic mechanisms and the severity of the clinical manifestations of the disease. When the etiological factor of CV development is established, etiotropic therapy is administered. Patients with severe or life-threatening manifestations require urgent intervention to suppress the formation of immune complexes. This is achieved by means of immunosuppressive therapy including glucocorticosteroids, cytostatics, rituximab, and plasmapheresis.
PRESENTATION OF ASSISTED REPRODUCTIVE TECHNOLOGIES IN THE DISCOURSE OF NEWS INTERNET PORTALS
Authors:   Grodno State Medical University, Salmina A.V.
Published: May 2022

The mass media in the modern world play an important role in forming public opinion. Interpretation of the problems associated with the introduction of assisted reproductive technologies (ART) in the media discourse does not have a single vector. The ambiguity and inconsistency of the judgments of sociologists, economists, doctors, journalists, and the church contribute to the formation of a wary attitude towards the new methods of ART introduction in society. Objectives. To identify the special features of the presentation of assisted reproductive technologies in the materials of news Internet portals of the Republic of Belarus and Russia. Material and methods. The study analyzed the articles on the types of assisted reproductive technologies from three Belarusian (BelTA, Onliner.by, Sputnik.by) and three Russian Internet publications (Rambler, Lenta.ru, RBC). Results. For the period from 08.01.2020 to 08.01.2021, a content analysis of 97 news articles on the topic of ART was carried out. Conclusions. The most popular types of technologies mentioned in the articles are in vitro fertilization, surrogacy and cryopreservation. According to statistical data there are more positive publications that reveal ART issues than negative ones. In vitro fertilization (IVF) gets more loyal coverage on news sites compared to surrogacy. This is due to the fact that in surrogacy, a third party (a surrogate mother) is directly involved in the birth of a child, which violates the so-called «intimate» side of family life.
Diuretic Activities of Root Bark Aqueous and Ethanolic Extracts of Parquetina nigrescens: I-Effects on Urinary Excretion in Wistar Rat
Authors: Konan Brou André , Kpahé Ziéhi Fidèle , Koko Koffi Bruno , Adepo Yapo Prosper
Published: May 2022

Background and objective: The root bark of Parquetina nigrescens is used in traditional medicine in the treatment of hypertension and edema for its diuretic properties. This study was conducted to examine the effects of this medicinal plant on the excreted urinary volume and contribute to scientific knowledge on its diuretic action. Methods: Water-overloaded rats were treated separately with increasing doses (5-70 mg/kg) of Parquetina nigrescens root bark aqueous and ethanolic 70 % extracts of and furosemide (FURO) at 5 mg/kg. Excreted urine was collected and measured. Results: Plant extracts caused increased urine excretion in rats. PNea 15 mg/kg and PNee 25 mg/kg were the most active doses. They caused an increase of volume of urine comparable to that induced by FURO 5 mg/kg. A very significant elimination of water overload at p < 0.001 was observed. And the recorded values were 42.73 ± 0.26% (PNea 15 mg/kg), 45.39 ± 0.190% (PNee 25 mg/kg) and 73.6 ± 0.24% (FURO 5 mg/kg) against 29.73 ± 0.24% (Saline solution NaCl 0.9%). Conclusion and perspectives: Increase of urine volume excreted induced by the extracts partly confirms the diuretic virtue of Parquetina nigrescens justifying its empirical use to treat hypertension and edema. However, these results, on their own, do not make it possible to elucidate the mechanism underlying diuretic activity of this plant. Additional studies should be carried out for this purpose.

Keywords: Diuretic activity, urinary excretion volume, Parquetina nigrescens, Furosemide
A Review Article on Dissolution Studies in Novel Drug Delivery System
Authors: Vyshnavi Kanupuru , Sinduja Y , Adeyemi Peter Gloria , Ebuka Agunwa Daniel , Srija Markanti , Sushma Gaddam
Published: May 2022

In present days there is immense advancement in drug delivery despite novel drug delivery has become civilized as pharmaceutical scientists has worked hard over it. However the vocal pathway remnant the excellent pathway is for administration whereas the new drugs achieve the great patient compliance. The dissolution studies in NDDS have limit literature also and to still found locate inside the pharmacopeia. The dissolution studies is highly and commonly recommended for the solid dosage forms now a days it’s indeed enlarged to the other pharmaceutical formulations like suspensions, patches etc .The dissolution tactic is indeed an perfect tool such as maintaining batch-batch evaluation tests and also to analyze the drug release in vivo conditions. In sustained release the products that are obtained has several advantages in optimizing bio pharmaceutics and pharmacokinetics as compared to the conventional drug delivery systems.

Keywords: Dissolution, sustained release, pharmacokinetics
Oral Fast Disintegrating Films of Phytochemicals: A Novel Drug Delivery System
Authors: Sayed Adnanulhaque M. , Kulkarni Abhijeet D. , Pardeshi Pooja U. , Kapile Chinmay R. , Nehe Akshay D.
Published: May 2022

Oral fast disintegrating films (OFDFs) have been developed as a viable alternative to conventional oral solid dosage forms such as tablets, capsules, and syrups for patients who struggle consuming them. OFDFs are thin strips that disintegrate or dissolve rapidly when placed in the oral cavity, allowing quick onset of action. These films are prepared by incorporating active pharmaceutical ingredients with film-forming polymers and other ingredients. OFDFs are also developed by incorporating active constituents present in phytochemicals such as flavonoids and polyphenols. In recent years, researchers have developed OFDFs by incorporating active phytoconstituents and/or herbal extracts to produce significant therapeutic activity. Phytochemical-based OFDFs show pharmacological activities such as anti-inflammatory, antiviral, immunomodulatory, antimigraine, antiarrhythmic, antioxidant and antibacterial. These films can also be used in the management of dementia, cerebral insufficiency and Alzheimer’s disease. The present review focuses on the formulation and development of phytochemical-loaded OFDFs and recent research carried out on the same in tabular form.

Keywords: Oral fast disintegrating film, phytochemicals, active phytoconstituents, herbal extracts, natural active compounds, oral mucosa, mouth dissolving film
Rational Use of Methylene Blue in COVID-19 Treatment
Authors: Saikrupa B V , Muthukumar Mani , Kavya S , Suma P Kumar
Published: May 2022

Methylene blue entered the medical field when Robert Koch and Paul Ehrlich introduced the staining of tuberculosis microorganisms using methylene blue. It is used as an anesthetic agent for its sensory nerve ending blocking property, and its antimicrobial activity was useful as an antimalarial therapy in the 1890s. In the modern medical field, methylene blue was majorly used for investigational purposes as contrast in many radiological diagnostic techniques. Further applications of methylene blue in various clinical indications like Alzheimer's disease, depression, and psychosis are under investigation. Human Coronavirus invasion through the ACE 2 receptor causes the immune system's activation and induces apoptosis in human cells like monocytes, macrophages, T lymphocytes, and dendritic cells, which results in the activation of the innate and acquired immune system. This process results in the massive elimination of the infected cells. Methylene blue can play a significant role in treating SARS-CoV-2 infection by inhibiting viral replication and preventing sepsis due to covid illness. Theoretically, anti-inflammatory activity, oxidative stress, and tissue damage caused by covid infection can be minimized, and thereby it can also be beneficial for the patients suffering from cytokine storm. From this review article, we conclude that methylene blue should be evaluated for its role in covid treatment at a clinical level.

Keywords: SARS-CoV-2, Antiviral activity, Cytokine storm, Nitric oxide, Antidote activity.