bluuebunny/crossref_metadata_2025 huggingface dataset:
The activeness, critical, and creative thinking skills of students in the Lesson Study-based inquiry and cooperative learning
Authors: Hasan Rusdi , Lukitasari Marheny , Utami Sri , Anizar Anizar
Published: March 2019

The implementation of innovative learning and lesson study (LS) are potential to improve student thinking skills and activeness differently and mostly implemented separately. This study aimed to explore and compare the student critical and creative thinking skills as well as student activeness in the inquiry and cooperative models combined with LS-based learning practice. This was a descriptive quantitative study that was conducted at Islamic Senior High School 1 of Bengkulu.  The sample was two classes consisted of 33 and 32 students each that conducted LS-inquiry and LS-cooperative learning. The essay test delivered to measure critical and creative thinking skills and observation sheet to measure student activeness. The data were analyzed by t-test to compare critical and creative thinking skills as well as the student activeness between the LS-inquiry and LS-cooperative classes. The result showed that LS-inquiry learning improved the student critical and creative thinking skills that significantly higher than LS-cooperative learning. The student activeness improved gradually as LS cycles during learning processes in either inquiry or cooperative learning, but no significant difference between these two learning models. It showed that inquiry learning plays a dominant influence in critical and creative thinking skills improvement, whereas LS in student activeness improvement otherwise.
Roofing granules with additive of copper-zinc powder having biocidal properties
Authors: Chervenko Yuriy V. , Almatov Alexey S. , Sokov Victor N.
Published: March 2019

Introduction. In the world practice, ceramic coated roofing granules with various biocidal (algicidal) additives are used to prevent discoloration of asphalt roofing shingle. The paper propose the application of the selective dissolution of brass process to accelerate the algicidal effect of surface mineral granules. The authors show that incorporating of brass pigment in the color coat of roofing granules provides the desired degree of algae resistance over an extended period of time. Materials and methods. The brass pigment powder was taken as an algicidal additive. Algae resistant granules with the brass pigment were made in Stroymineral plant. Standard AR granules from North America market were taken as a control sample. Algicidal effect was measured by comparison of control sample and manufactured algae retardant granules performance in the 4 weeks quantitative spectrophotometric chlorophyll test. Measurement of an optical density of the liquid culture solution were made to determine the algae growth rates. The measurement was performed in the laboratory for the development of innovative medicines and biotechnologies in MIPT University. Results. The results show that manufactured algae retardant granules displayed level of the algicidal activity which is equal to control sample during the research. It was found that the highest algicidal activity was shown by products manufactured using finely dispersed copper-zinc alloy powder with a zinc content between 15-30 %. Conclusions. The manufactured granules with brass pigment in the color coating reveal ability to inhibit the algae growth.
Graphic method of calculation of the direct solar radiation received on the facade with available opposing building
Authors: Korkina Elena V.
Published: March 2019

Introduction. An approach to the development of a method for taking into account the influence of a single opposing building on direct solar radiation inflows to the building under study, taking into account all the irradiation periods of the facade under study, is presented. When calculating the consumption of thermal energy for heating and ventilation of a building in accordance with the method presented in regulatory documents, it is necessary to perform calculations of heat gain to the building from solar radiation. These calculations are carried out without taking into account the influence of the opposing building, what reduces the accuracy of the results. In foreign and domestic literature sources not found suitable for construction calculations and taking into account all periods of exposure methods. The objectives of this study are: the mathematical substantiation of the method, the possibility of its practical application, the formation of the calculation algorithm. Materials and methods. Calculations of the angular height and azimuth of the Sun by astronomical formulas, trigonometric calculations, construction of graphs of the tangents of changes in solar coordinates from the true solar time are applied. Results. The graphical method is proposed for determining irradiation periods by direct solar radiation of a facade of any orientation. The method is based on consideration of the formulas of the solar coordinates and the location of the opposing building. In this case, the graphic field is used to plot the changes in the tangents of the angular height of the Sun and the tangents of the difference between the azimuths of the Sun and the normal to the surface of the facade from the true solar time. The parameters of the building are applied to the graphic field and, in accordance with the proposed recommendations, the periods of irradiation of the facade are determined. Then the summation of direct solar radiation for the periods of irradiation of the facade is made. The algorithm of calculations on the example of a building in the presence of an opposing building is presented. The decrease of incoming direct solar radiation is shown. Conclusions. The developed graphic method is mathematically justified, has a practical orientation, which makes it relevant to the purpose and easy to use. The calculations for the presented method showed a significant decrease in the received direct solar radiation compared with the calculation without taking into account the influence of the opposing building, which shows the need to apply the method. The implementation of the method will contribute to an increase in the accuracy of calculations of direct solar radiation received on the facade and, therefore, the accuracy of calculations of energy consumption for heating and ventilation of the building.
Efectos del cambio climático: Una mirada al Campo
Authors: Arteaga N. Luis Enrique , Burbano N. Jairo Efrén
Published: March 2019

El cambio climático afecta de manera sensible al sector agropecuario, lo cual genera conflictos sociales, pérdidas económicas y pone en riesgo la seguridad alimentaria de la población; tal como se ha podido evidenciar durante los periodos de lluvias intensas y sequía presentados durante los fenómenos del niño y de la niña en Colombia. La solución a esta problemática requiere de procesos de planeación a largo plazo, basados en la recuperación de los ecosistemas, el uso de nuevas tecnologías y en la consolidación de una nueva identidad cultural orientada en la sostenibilidad, tal como se expresa en los planes y políticas de cambio climático del país. Esta revisión aborda los escenarios de cambio climático de Colombia y el departamento de Nariño, y evalúa los posibles impactos en el sector agropecuario; así como las diferentes acciones de mitigación y adaptación implementadas a nivel regional. Finalmente, se abordan algunas experiencias exitosas en América Latina como el cultivo de variedades resistentes al estrés climático, los sistemas agroforestales, la cosecha de agua y la lluvia sólida.
A Game of Surface Codes: Large-Scale Quantum Computing with Lattice Surgery
Authors: Litinski Daniel
Published: March 2019

Given a quantum gate circuit, how does one execute it in a fault-tolerant architecture with as little overhead as possible? In this paper, we discuss strategies for surface-code quantum computing on small, intermediate and large scales. They are strategies for space-time trade-offs, going from slow computations using few qubits to fast computations using many qubits. Our schemes are based on surface-code patches, which not only feature a low space cost compared to other surface-code schemes, but are also conceptually simple~--~simple enough that they can be described as a tile-based game with a small set of rules. Therefore, no knowledge of quantum error correction is necessary to understand the schemes in this paper, but only the concepts of qubits and measurements.
Craniology and archeology of the east manych catacomb culture - perspectives of the analysis of the consistency of signs
Authors: Kazarnizki Alexey Aleksandrovich , Panasyuk Nathalia V
Published: March 2019

This thesis demonstrates results of a comparison of new published craniological data of the East Manych catacomb culture population (Middle Bronze Age, North-Western Caspian region), of the funeral rites and the artifacts’ assortments in the burials of this culture and the types of decoration of incense burners - the special ceramic vessel. At least the more frequent appearance of incense burners in burials of individuals with an artiﬁcial deformation of the head (both men and women) is detected. Any other combinations of craniological and archaeological features are doubtful. The comparison of incense burners’s decoration and attributes funeral rite demonstrates the correlation of point type of décor and more frequent use of bronze knives and piercers.
Verdensmålene: En vision for verden
Authors: Hildebrandt Steen
Published: March 2019

Verdensmål. Verdens mål. Mål for verden! Kan man forestille sig noget større eller mere revolutionerende, udfordrende, respektindgydende og håbefuldt? Menneskehedens, homo sapiens’ historie spænder over ca. 300.000 år. Planeten Jordens historie går 4,5 milliarder år tilbage. Der har været liv på Jorden i 3,8 milliarder år. Fem gange i disse milliarder år har der været såkaldte masseuddøener, dvs. perioder, hvor meget store dele af alt liv på Jorden døde. Sidste gang - den femte masseuddøen - var for ca. 66 millioner år siden, og her antages det, at ca. 75 pct. af alt liv på Jorden blev udslettet. Spørger man på Københavns Universitet eller på andre universiteter rundt om i verden, vil man få at vide, at vi lige nu befinder os i begyndelsen af den sjette masseuddøen. Vi skal omgås dette ord med forsigtighed, men vi skal ikke lukke vore øjne for, at der sker alvorlige begivenheder på planeten jorden, og at nogle af disse begivenheder og fænomener er skabt af mennesker. De er forårsaget af menneskelig aktivitet. Carsten Rahbek, professor ved Center for Makroøkologi, Evolution og Klima ved Københavns Universitet, siger: ”Dyre-og plantearter indgår i et komplekst økosystem med hinanden det sted, hvor de lever. Fjerner man enkelte arter, bliver systemet ustabilt. På et tidspunkt kollapser det. Vi ved ikke nok om, hvad der præcist skal til, for at et økosystem kollapser, men vi ved, at vi leger med ilden i øjeblikket”.
Skam æder anerkendelser op – præsentation af et skjult ledelsesproblem ved stress
Authors: Pedersen Pernille Steen
Published: March 2019

Denne artikel præsenterer skam som et nyt og skjult ledelsesproblem. Med afsæt i kvalitative interviews fra to forskellige forskningsprojekter viser jeg, hvordan skam dukker op i et moderne arbejdsliv i forbindelse med stress. Efter at have præsenteret forskningsprojekterne og min analysetilgang, viser jeg forskellige situationer, hvori skamfølelsen dukker op som et ledelsesproblem. Herefter introduceres to reaktionsmønstre på skam som afsæt til, at jeg afslutningsvis kan pege på relationen og kommunikationen mellem leder og medarbejder samt kollegaer indbyrdes som stedet, hvor skamfølelsen kan håndteres med henblik på at forebygge yderligere forværring af skam. Målet med artiklen er at kaste lys over en ny problemstilling i forbindelse med stress, som jeg fortsat er i gang med at udforske. Artiklen skal betragtes som en invitation til at få indblik i en opdagelsesrejse, med de forbehold det nu engang indebærer. Jeg håber, at læseren vil tage med på rejsen og bruge den præsenterede viden som inspiration til eget arbejde – frem for at betragte den som en fiks og færdig teori.
Tejido y educación ambiental en comunidades kichwas de Tena, Ecuador
Authors: Bacquet Pérez Caroline Nicole Oriana , Batres Quevedo Jorge Alejandro
Published: March 2019

Este artículo se originó en una experiencia con esas características: tejer animales amazónicos con mujeres kichwas, como una estrategia de educación y de conservación ambiental, sin encuadre educativo formal, objetivos predefinidos o metas preestablecidas. A medida que el proceso avanzó, fue mostrando otras utilidades: posibilidades de emprendimiento productivo, generación de un ambiente propicio para múltiples aprendizajes, desarrollo de vínculos entre mujeres e interrelación entre la conservación de la diversidad biológica y la cultural. Por ser un proceso abierto, no pueden compartirse conclusiones de conocimiento, pero sí experiencias y aprendizajes que pueden servir de referencia para proyectos similares.
Politización evangélica en Costa Rica en torno a la agenda “provida”: ¿Obra y gracia del Espíritu Santo?
Authors: Fuentes Belgrave Laura
Published: March 2019

A partir de la descripción de los antecedentes de la representación política evangélica en Costa Rica, se aborda el análisis de la coyuntura experimentada en el Estado con motivo de las elecciones presidenciales de 2018, cuando un partido político de inspiración cristiana alcanza la posibilidad de llevar su discurso religioso al aparato gubernamental. Para el análisis sociológico del caso, se propone utilizar una perspectiva histórica y comparativa que entrelaza ejes de desintegración social, politización de lo religioso y comunicación política, elaborados a partir de la coyuntura mencionada. Estos ejes son examinados con base en investigaciones previamente realizadas sobre los vínculos entre iglesias católicas y cristiano-evangélicas, con los cambios en las prácticas y creencias religiosas, y su conexión con los derechos sexuales y reproductivos.
Alianzas interreligiosas que retan la laicidad en México
Authors: De la Torre Reneé
Published: March 2019

Este ensayo describe la diversificación religiosa en México que conduce a una recomposición de las relaciones religiones y política. Los evangélicos representan un nuevo actor político que desafía a la laicidad; recientemente, han establecido alianzas estratégicas inusitadas que retan a repensar la laicidad para México. El marco constitucional de la laicidad mexicana fue pensado para contener la acción directa de las cúpulas católicas en la política, pero en el presente está rebasado. Este ensayo retoma la propuesta del triángulo equilátero de la laicidad contemporánea de Baubérot (2007) para reflexionar sobre los dilemas y las posibles salidas para lograr una laicidad, que contemplen tanto el pluralismo religioso, la separación Estado-iglesias, como la libertad de conciencia y sus consecuencias.
Risk-return analysis of M&A investments. A theoretical equity cost framework for the valuation process of private companies’ acquisitions
Authors: Orlando Beatrice , Renzi Antonio , Vagnani Gianluca
Published: March 2019

M&A deals often have private companies as the target. One of the main concerns of this investment type is how to evaluate the target when the target is a private firm. In fact, traditional Capital Budgeting metrics are at least even inconsistent when it comes to define the target value of a private company because such measures are mostly made for public companies. As the negative outcome of this practice, the quality of the evaluation might be poor because of the imprecise discount factor used for the overtime estimate of the target's free cash flows. Building on such cues, the paper proposes a theoretical framework aimed to reinterpret the risk-return analysis of equity by re-calibrating the evaluation process on the firm's fundamental. We argue the equity cost of the private firm can be measured as the combination of the following three factors: i) intrinsic business risk tied to competitive environment volatility; ii) structural characteristics of the firm; iii) capital market dynamics. Adopting a bottom up logic, the exposition to the capital market's volatility of a private firm depends both on the combination between its structural characteristics and on the systematic risk averagely absorbed by the industry in which the company operates. Our conceptual contribution accomplishes two major goals. First, it links the equity cost of the private firm to contingency. Second its application, highlighting linkages between structural variables of the target company and its risk-return dynamics, may improve M&A decisions in terms of a better trade-off between strategic growth and risk mitigation
Suitability of alternative dispute resolution for shareholders disputes
Authors: Kaya Serkan
Published: March 2019

Most companies listed in the United Kingdom are closely held corporations whose shares are not publicly traded. Apparently, these small quasi-partnership types of private limited companies play an essential role in the United Kingdom economy. Even though the power of personal/family relations offers advantages for shareholders to work together in a privately held business, minority shareholders are vulnerable as compared to the majority shareholders. Therefore, minority shareholder disputes are of concern principally to private companies with management ownership concentrated in the hands of a small group of family members (Mak, 2017). Court-based shareholder proceedings are not appropriate way to prevent the relational breakdown due to unresolved personal conflicts among shareholders and are costly and complex regarding evidentiary and procedural rules. This paper explores the suitability of Alternative Dispute Resolution Methods for shareholders disputes
Institutional shareholders and corporate governance
Authors: Berglund Tom , Alimov Naufal
Published: March 2019

In a an overall equilibrium in asset markets there will be different types of institutions that are fundamentally different in terms of the required skill sets of their key employees. These different skill sets are optimal for pursuing different types of policies regarding what assets the institution should invest in. Our paper highlights how previous empirical results concerning the impact of different types of institutions’ ownership on corporate governance can be understood in terms of required skill sets and corresponding incentives
Seasonal temperature variation of solar pond under Mediterranean condition
Authors: Sogukpinar Haci
Published: March 2019

In this paper, thermal performance of solar pond for different condition was numerically investigated by using discrete ordinates method to facilitate a greater understanding of the effects of relative various condition on thermal performance improvement of solar pond. For this, a 3-D prototypes of solar ponds with square cross-sections were simulated for the oversoil and subsoil, insulated and uninsulated, open on and off conditions. The direction of sunlight (zenith angle and the solar elevation) was automatically computed from the latitude, longitude, time zone, date, and time. The estimated solar position is accurate for a date between year 2000 and 2199, due to an approximation used in the Julian Day calendar calculation. Seasonal temperature variation of solar pond was calculated for the full period of one year starting from March and calculated data were compared with experiment to validate simulation accuracy of heat transfer model. Result indicates that temperatures in the summer time were calculated at around 55?C, while temperatures in the winter were in the range of 20 to 30?C and temperature changes between 30?C and 40?C in spring and autumn.
Performance analysis of a four-stroke compressed air engine
Authors: Zeng Fancong , Xu Jinli
Published: March 2019

The purpose of this paper is to investigate working performance for a four-stroke compressed air engine via numerical studies. A mathematical model is developed to study the influence of several operative parameters on working performance. The mathematical model consists of thermodynamic model, each stroke model and dynamic model. In addition, a working principle and an experimental system of the compressed air engine are set up. The aims are: to introduce the novel four-stroke engine and to quantify the influence of rotational speed, supply pressure and supply temperature on working characteristics. The simulation and analysis show several meaningful results. The compressed air engine has higher cylinder pressure and work efficiency in lower speed stage, and the increase of the supply pressure can effectively improve indicated work and work efficiency. However, supply temperature has little effect on the performance of the compressed air engine. Therefore, the study of this work will provide a certain guidance function for further study on optimizing design of the compressed air engine.
A comprehensive review on pool boiling heat transfer using nanofluids
Authors: Khan Asif , Ali Hafiz
Published: March 2019

Nanofluids are suspensions of nanoparticles with small concentration spread in base fluids such as water, oil and ethylene glycol. Nanofluid boiling is an important research area which provides many chances to explore new frontiers but also poses great challenges. Over the last decade, various studies have been carried out on pool boiling of nanofluids for the enhancement of critical heat flux which is otherwise limited by the use of base fluids. Several efforts have been made in the literature on nanofluid boiling, however, data on the boiling heat transfer coefficient and the critical heat flux have been unpredictable. Current study is a review of the status of research work on effects of nanofluids on heat transfer coefficient and critical heat flux. An emphasis is put in a review form on the recent progresses in nanofluid heat transfer coefficient and critical heat flux of pool boiling. This study also focuses on advancements in nanofluids, their properties and various parameters affecting boiling critical heat flux and heat transfer coefficient. At the end correlations used by different researchers to find out the critical heat flux and heat transfer coefficient are listed.
Loss-of-Function Mutation in Thiamine Transporter 1 in a Family With Autosomal Dominant Diabetes
Authors: Jungtrakoon Prapaporn , Shirakawa Jun , Buranasupkajorn Patinut , Gupta Manoj K. , De Jesus Dario F. , Pezzolesi Marcus G. , Panya Aussara , Hastings Timothy , Chanprasert Chutima , Mendonca Christine , Kulkarni Rohit N. , Doria Alessandro
Published: March 2019

Solute Carrier Family 19 Member 2 (SLC19A2) encodes thiamine transporter 1 (THTR1), which facilitates thiamine transport across the cell membrane. SLC19A2 homozygous mutations have been described as a cause of thiamine-responsive megaloblastic anemia (TRMA), an autosomal recessive syndrome characterized by megaloblastic anemia, diabetes, and sensorineural deafness. Here we describe a loss-of-function SLC19A2 mutation (c.A1063C: p.Lys355Gln) in a family with early-onset diabetes and mild TRMA traits transmitted in an autosomal dominant fashion. We show that SLC19A2-deficient β-cells are characterized by impaired thiamine uptake, which is not rescued by overexpression of the p.Lys355Gln mutant protein. We further demonstrate that SLC19A2 deficit causes impaired insulin secretion in conjunction with mitochondrial dysfunction, loss of protection against oxidative stress, and cell cycle arrest. These findings link SLC19A2 mutations to autosomal dominant diabetes and suggest a role of SLC19A2 in β-cell function and survival.
Long-term Association of Depression Symptoms and Antidepressant Medication Use With Incident Cardiovascular Events in the Look AHEAD (Action for Health in Diabetes) Clinical Trial of Weight Loss in Type 2 Diabetes
Authors: Hazuda Helen P. , Gaussoin Sarah A. , Wing Rena R. , Yanovski Susan Z. , Johnson Karen C. , Coday Mace , Wadden Thomas A. , Horton Edward S. , Van Dorsten Brent , Knowler William C. ,   for The Look AHEAD Research Group
Published: March 2019

OBJECTIVE

To examine whether depression symptoms or antidepressant medication (ADM) use predicts the probability of cardiovascular events in overweight/obese individuals with type 2 diabetes.

RESEARCH DESIGN AND METHODS

Preplanned analyses of depression and incident cardiovascular disease (CVD) were performed in the Look AHEAD (Action for Health in Diabetes) weight loss trial after a median follow-up of 9.6 years. Depression symptoms, assessed with the Beck Depression Inventory (BDI), were analyzed both as a continuous and dichotomized variable (BDI score <10 or ≥10). ADM use was coded from participants’ prescription medications. Four composite CVD outcomes were defined in the study protocol. Sex-stratified Cox proportional hazards models were adjusted for a range of baseline covariates.

RESULTS

Depression symptoms were only significantly associated with a composite secondary outcome comprising CVD death, nonfatal myocardial infarction, nonfatal stroke, hospitalized angina, congestive heart failure, peripheral vascular disease, coronary artery bypass graft, and carotid endarterectomy. Significant sex interactions were observed for BDI score and BDI score ≥10. BDI score was significantly associated with higher probability of this composite outcome in men but was not associated with the outcome in women. BDI score ≥10 was positively associated with this composite outcome in men but was negatively associated in women. Exploratory analysis identified a significant BDI ≥10 × ADM use interaction for this composite outcome that differed in men versus women. Men with both BDI score ≥10 and ADM use compared with those with neither had 60% higher probability of the outcome, whereas women with both compared with those with neither had 50% lower probability.

CONCLUSIONS

Sex differences in the association of depression symptoms and ADM use with incident CVD warrant further investigation.
Placental 11β-HSD2 and Cardiometabolic Health Indicators in Infancy
Authors: Chen Lu , Guilmette Julie , Luo Zhong-Cheng , Cloutier Anik , Wang Wen-Juan , Yang Meng-Nan , Fraser William D. , Dubois Josée , Nuyt Anne Monique
Published: March 2019

OBJECTIVE

Fetal excessive exposure to glucocorticoids may program cardiometabolic risk. Placental 11 β-hydroxysteroid dehydrogenase 2 (11β-HSD2) serves as a barrier to prevent fetal overexposure to maternal glucocorticoids. It has not been explored whether placental 11β-HSD2 levels are associated with cardiometabolic health in postnatal life.

RESEARCH DESIGN AND METHODS

In a prospective birth cohort study of 246 mother-infant pairs, we measured placental 11β-HSD2 expression and maternal (32–35 weeks of gestation) and cord plasma cortisol concentrations. The primary outcomes were HOMA of insulin resistance (IR) and blood pressure (BP) in infants at age 1 year. Other outcomes included fasting insulin, HOMA β-cell function, carotid intima-media thickness, weight z score, and skinfold thickness (triceps and subscapular) at age 1 year.

RESULTS

Placental 11β-HSD2 expression was negatively correlated with HOMA-IR (r = −0.17, P = 0.021) and fasting insulin (r = −0.18, P = 0.017) and marginally negatively correlated with systolic BP (r = −0.16, P = 0.057) but was not correlated with HOMA of β-cell function, diastolic BP, carotid intima-media thickness, and skinfold thickness (all P > 0.1) in infants at age 1 year. Cord plasma cortisol was negatively correlated to skinfold thickness (r = −0.20, P = 0007) but was not correlated with other outcomes at age 1 year. Maternal plasma cortisol was positively correlated with maximal carotid intima-media thickness (r = 0.20, P = 0.03) but was not correlated with other outcomes. Adjusting for maternal and infant characteristics, the associations were similar.

CONCLUSIONS

The study is the first to show that higher placental 11β-HSD2 expression is associated with lower IR in infancy. Independent cohort studies are required to confirm this novel finding.
Improved Time in Range and Glycemic Variability With Sotagliflozin in Combination With Insulin in Adults With Type 1 Diabetes: A Pooled Analysis of 24-Week Continuous Glucose Monitoring Data From the inTandem Program
Authors: Danne Thomas , Cariou Bertrand , Buse John B. , Garg Satish K. , Rosenstock Julio , Banks Phillip , Kushner Jake A. , McGuire Darren K. , Peters Anne L. , Sawhney Sangeeta , Strumph Paul
Published: March 2019

OBJECTIVE

To evaluate effects of the dual sodium–glucose cotransporter (SGLT) 1 and SGLT2 inhibitor sotagliflozin in combination with insulin on glucose time in range (TIR) and glucose excursions, postprandial glucose (PPG), and other glycemic metrics in adults with type 1 diabetes using masked continuous glucose monitoring (CGM).

RESEARCH DESIGN AND METHODS

Data sets from the inTandem1 (clinical trial reg. no. NCT02384941) and inTandem2 (clinical trial reg. no. NCT02421510) double-blind randomized trials evaluating sotagliflozin versus placebo in adults with type 1 diabetes treated with optimized insulin were pooled for analyses of masked CGM data from a subset of participants in each trial. The pooled cohort included patients randomized to receive placebo (n = 93), sotagliflozin 200 mg (n = 89), or sotagliflozin 400 mg (n = 96). The primary outcome was change from baseline to week 24 in glucose TIR (3.9–10.0 mmol/L [70–180 mg/dL]). Secondary end points included time below and above the target range and 2-h PPG level assessed after a standardized mixed meal.

RESULTS

Mean percentage of glucose TIR/percentage time spent at <3.9 mmol/L (<70 mg/dL) during week 24 was 51.6%/5.9%, 57.8%/5.5%, and 64.2%/5.5% with placebo, sotagliflozin 200 mg, and sotagliflozin 400 mg, respectively, which corresponded to a placebo-adjusted change from a baseline of +5.4%/−0.3% (P = 0.026; +1.3/−0.1 h/day) for sotagliflozin 200 mg and +11.7%/−0.1% (P < 0.001; +2.8/−0.02 h/day) for sotagliflozin 400 mg. Placebo-adjusted PPG reductions were 1.9 ± 0.7 mmol/L (35 ± 13 mg/dL; P = 0.004) and 2.8 ± 0.7 mmol/L (50 ± 13 mg/dL; P < 0.001) with sotagliflozin 200 and 400 mg, respectively.

CONCLUSIONS

Combined with optimized insulin in type 1 diabetes, sotagliflozin significantly increased glucose TIR without increasing time spent at <3.9 mmol/L and reduced PPG, thereby improving glycemic control.
PENGARUH PERUBAHAN FUNGSI LINGKUNGAN BINAAN TERHADAP CITRA KAWASAN WISATA TEKSTIL CIGONDEWAH KOTA BANDUNG
Authors: Wijaya Karto , Setioko Bambang , Murtini Titin Woro
Published: March 2019

Abstract: The Cigondewah is a region that become the tourist area of cloth shopping, majority of the Cigondewah region user are salesman and businessman that mostly are the main economic agents. The marketing activity that growth and develop can affect the building in corridor around the market. The presence of the textile industry region in those area gives its own color to the changes in the built environment functuin in the road corriodor of Cigondewah. This study aims to determine the effect of the changes in the built environment function against the image of the textile tourism region in Cigondewah in Bandung. The quantitative rationalistic are used with gathering data through literature study, questionaires, and fi eld observation. The statistic data analyzing with regression test use SPSS 19.0 software for Windows. The result of this study show that there are signifi cant changes of built environment function against the image of textile tourism region in Cigondewah in Bandung at 41,0%, while the rest at 59.0% that form the region image, are affected by other model outside this study.Keywords: The changes of Built Environment Function, Region image, Textile tourismAbstrak: Kawasan Cigondewah merupakan kawasan yang menjadi area wisata belanja kain, mayoritas pengguna kawasan Cigondewah ini di antaranya pedagang dan pengusaha yang sebagian besar merupakan penghuni sebagai pelaku ekonomi utama. Kegiatan aktivitas perdagangan yang tumbuh dan berkembang dapat mempengaruhi bangunan pada koridor di sekitar perdagangan tersebut. Adanya kawasan industri tekstil di kawasan tersebut memberikan warna tersendiri terhadap perubahan fungsi lingkungan pada koridor jalan Cigondewah. Penelitian ini bertujuan untuk mengetahui pengaruh perubahan fungsi lingkungan binaan terhadap citra kawasan wisata tekstil di Cigondewah Kota Bandung. Metode kuantitatif rasionalistik digunakan dengan pengumpulan data melalui studi literatur, kuesioner dan observasi lapangan. Analisis data Statistik dengan uji regresi menggunakan software SPSS 19.0 for Windows. Hasil dari penelitian ini menunjukkan adanya pengaruh perubahan fungsi lingkungan binaan terhadap citra kawasan wisata tekstil di Cigondewah Kota Bandung sebesar 41,0 %, sedangkan sisanya sebesar 59.0 % yang membentuk citra kawasan dipengaruhi oleh model yang lain di luar dari penelitian ini.Kata kunci: Perubahan Fungsi Lingkungan Binaan, Citra kawasan, Wisata Textile
CAIR SEBAGAI KONSEP DESAIN INTERIOR RESTORAN TIMOR RAYA KOTA KUPANG
Authors: Lily Budhi B.
Published: March 2019

Abstract: Timor Raya Restaurant comes from the proliferation of places that offer rental services of wedding packages in the city. The initial function of this restaurant was a venue for weddings with supported interior concept. As the time goes by, the restaurant also rented out for other events such as birthdays, graduations, meetings and gathering severance and other events that makes the interior concept incompatible anymore with such events. Flexibility of  the interior space is the main problem of this restaurant and to study about it can use the "liquid" philosophy at the meaning of sirih pinang as a local wisdom potential. The purpose of this study is to present an interior design of Timor Raya Restaurant with "liquid" concept that can provide solutions to respond to some of the functions contained. Data collection method is done by observation and interviews and analyze with qualitative method to each element of the interior with the "liquid" concept. The results showed that by the application of  "liquid" concept  against every element make the interior concept of Timor Raya Restaurant can adjust to every event hold.Keywords: Liquid, interior, Timor Raya RestaurantAbstrack: Restoran Timor Raya hadir dari maraknya tempat-tempat yang menawarkan jasa penyewaan paket pernikahan di Kota Kupang. Fungsi awal restoran ini adalah sebagai tempat berlangsungnya acara pernikahan dengan konsep iterior yang mendukung. Berjalannya waktu restoran ini disewakan juga untuk acara-acara lain seperti ulang tahun, wisuda, pertemuan dan temu pisah serta acara lainya yang mengakibatkan konsep interior yang ada tidak cocok dengan acara-acara tersebut. Masalah fleksibilitas ruang interior merupakan masalah utama dari restoran ini dan untuk mengkajinya dapat menggunakan filosofi “cair” pada makna sirih pinang sebagai potensi kearifan lokal. Tujuan penelitian ini adalah untuk  menghadirkan sebuah desain interior Restoran Timor Raya dengan konsep “cair” yang dapat memberikan solusi untuk merespon beberapa fungsi yang diwadahi. Metode pengumpulan data dilakukan dengan observasi dan wawancara serta menganalisisnya dengan metode kualitatif terhadap setiap elemen interior dengan konsep “cair”. Hasil penelitian menunjukan bahwa dengan aplikasi konsep ”cair” terhadap setiap elemen membuat konsep interior Restoran Timor Raya dapat menyesuaikan dengan setiap acara yang diwadahi.Kata kunci: Cair, interior, restoran timor raya
APLIKASI VARIABEL PENYERAP BUNYI SEDERHANA UNTUK WAKTU DENGUNG FREKUENSI MENENGAH ATAS PADA AUDITORIUM FAKULTAS KEDOKTERAN UGM
Authors: Ola Frengky Benediktus
Published: March 2019

Abstract: Multifunctional auditorium must accommodate two primary functions, namely speech and music performances. Both of these functions have different quality demands in order to satisfy the audience. On a multifunctional auditorium, the difference n of user will affect the value of reverberation time. A simple absorbent made of curtain which opened and closed will use for extend or shortening the value of reverberation time, particularly middle-high frequency. The study was conducted by method of simulation using the CATT Acoustic software. Research results showed the influence of curtain on the stability value of middle-high frequency reverberation time related to the number of audience.Keyword: Acoustic, auditorium, variable absorbency, simulation, substitutionAbstrak: Auditorium multifungsi harus mengakomodasi dua kelompok fungsi utama yaitu pidato dan pentas musik. Kedua fungsi tersebut memiliki tuntutan kualitas yang berbeda untuk memuaskan audien. Pada ruang auditorium multifungsi, perbedaan jumlah pengguna ruang akan mempengaruhi nilai waktu dengung. Penyerap bunyi sederhana akan memanfaatkan korden yang dibuka dan ditutup dan berakibat memperpanjang atau memperpendek nilai waktu dengung, khususnya frekuensi menengah atas. Penelitian dilakukan dengan metode simulasi berbantuan perangkat lunak CATT Acoustic. Hasil penelitian menegaskan, terdapat pengaruh penggunaan korden pada kestabilan nilai waktu dengung frekuensi menengah-atas berkaitan dengan jumlah audien.Kata Kunci: Akustika, auditorium, variabel penyerap, simulasi, substitusi
POLA AKTIVITAS RUANG TERBUKA PUBLIK PADA KAWASAN TAMAN FATAHILLAH JAKARTA
Authors: Hantono Dedi
Published: March 2019

Abstract: Fatahillah Park in front of Fatahillah Museum is part of Jakarta Kota area (called Kota Tua, Old Town) which is a conservation area. Fatahillah Park currently serves as a public open space surrounded by historic buildings on four sides. As a public open space, Taman Fatahillah is visited by people from various regions in Indonesia and foreign tourists, so there are various activities in it. This paper describes the results of research on the pattern of human activity (visitors) in Taman Fatahillah. The research used qualitative approach and descriptive analysis method. As a result, as a public open space, Taman Fatahillah is accessed by anyone and within the timeframe from morning to evening. Activities that take place in Taman Fatahillah are dominated by secondary actors (visitors) while the primary actors (traders) are limited by a certain place and time. The activity on the path space forms a linear pattern and on an open field forming a random pattern.Keywords: public open space, activities, area, conservation, urban designAbstrak: Taman Fatahillah di depan Museum Fatahillah adalah bagian dari kawasan Jakarta Kota (disebut Kota Tua) yang merupakan kawasan konservasi. Taman Fatahillah saat ini berfungsi sebagai ruang terbuka publik yang dikelilingi oleh bangunan-bangunan bersejarah pada empat sisi. Sebagai ruang terbuka publik, Taman Fatahillah didatangi orang-orang dari berbagai daerah di Indonesia dan wisatawan manca negara, sehingga muncul beragam aktifitas di dalamnya. Tulisan ini memaparkan hasil penelitian tentang pola aktivitas manusia (pengunjung) di Taman Fatahillah. Penelitian menggunakan pendekatan kualitatif dan metode analisis deskriptif. Hasilnya, sebagai ruang terbuka publik, Taman Fatahillah diakses oleh siapa saja dan dalam rentang waktu dari pagi hari hingga malam hari. Aktivitas yang berlangsung di Taman Fatahillah didominasi oleh pelaku sekunder (pengunjung) sedangkan pelaku primer (pedagang) dibatasi oleh tempat dan waktu tertentu. Aktivitas pada ruang jalan membentuk pola linier dan pada lapangan terbuka membentuk pola acak.Kata Kunci: ruang terbuka publik, aktivitas, kawasan, konservasi, rancang kota
MAKNA RUANG DALAM BUDAYA MASYARAKAT SIKKA
Authors: Kian Donatus Ara , Rayawulan Robertus M. , Mberu Yuliana , Lily Budhi B.
Published: March 2019

Abstract: The essence of human existence depends on the environment and fellow humans. The activity of human life takes place in space and to show its existence human beings always create space, so that there is a process of human settlement in a certain place. The culture of settling in the people of East Nusa Tenggara creates certain patterned settlements. The phenomenon of living culture-based occurs in the Sikka community. Space philosophy emerged in the process of building houses and villages in the Sikka community. This paper presents the meaning of space in the culture of the settlements of the Sikka community. Research carried out with a qualitative paradigm, presented descriptively and associated with relevant literature. As a result, the culture settled and built the residence of the tribes within the village (Wisung-wagang), kampung, magical concepts (Lero and kala), and Amerta were closely related to the concepts and meaning of space according to the culture of the Sikka community.Keywords:space, culture, house, Sikka communityAbstrak: Hakekat keberadaan manusia bergantung pada lingkungan dan sesama manusia. Aktivitas kehidupan manusia berlangsung dalam ruang dan untuk menunjukkan eksistensinya manusia selalu menciptakan ruang, sehingga terjadi proses bermukim manusia pada tempat tertentu. Budaya bermukim pada masyarakat Nusa Tenggara Timur menciptakan permukiman berpola tertentu. Fenomena bermukim berbasis budaya terjadi di kalangan masyarakat Sikka. Filosofi ruang muncul pada proses pembangunan rumah maupun kampung di kalangan masyarakat Sikka. Tulisan ini memaparkan makna ruang dalam budaya bermukim masyarakat Sikka. Penelitian dilakukan dengan paradigma kualitatif, disajikan secara deskriptif dan dikaitkan dengan pustaka yang relevan. Hasilnya, budaya bermukim dan membangun tempat kediaman suku-suku dalam kampung (Wisung-wagang), kampung, konsep magis (Lero dan kala), dan Amerta berkaitan erat dengan konsep dan makna ruang menurut budaya masyarakat SikkaKata kunci; ruang, budaya, rumah, masyarakat Sikka
Analysis of factors affecting the durability and reliability of selected components of ship engines - in the aspect of technical operation
Authors: Łosiewicz Zbigniew , Mikuła Tadeusz
Published: March 2019

The article discusses factors affecting the durability and reliability of selected marine engine components. Such an analysis may accentuate the importance of selection of crews sailing to ships with a defined operational suitability, which affects the safety of navigation.
Construction of cylindrical toothed gear with a corrected teeth in Inventor. Generator of a cylindrical toothed gear
Authors: Maciejczyk Andrzej
Published: March 2019

The article presented the process of construction of a corrected cylindrical gear with straight teeth. The operation of the gear generator is discussed. The procedure of gear engagement correction based on P0 type correction was indicated. Preliminary calculations were made using analytical methods. The work of the generator of gear components was analyzed. Calculation module errors are indicated.
Research position for testing cyclo gear fatigue
Authors: Matczak Joanna , Matczak Kamil
Published: March 2019

Paper discussed the research position for testing cyclo gear fatique and durability of cyclo gear mesching. Particular attention was paid to the construction of Cyclo gear and the individual elements of the test bench. The authors presents the possibility of measuring the position thanks to the use additional sensors.
Positioning process model of the object on the cross-belt sorter trays
Authors: Piątkowski Tomasz
Published: March 2019

The paper concerns modelling of the translational and rotational positioning process of cuboidal objects with the system of adjacent conveyors. During the theoretical analysis, the friction model available in the MSC Adams environment was taken into account. The process of translational positioning is carried out with two conveyors with such selected velocities to ensure static friction state and minimize the influence of inertia forces on the object motion. Rotational positioning is performed by a system of two adjacent conveyors moving in opposite directions. By properly selecting the acceleration of the belt motion and the time of carrying out this movement, it is possible to precisely move and rotate the object from the initial position to the given end position. The results of numerical tests show that the coefficient of friction of an object does not have a significant effect on the course of the rotation process. In case of rotational positioning of objects with different external dimensions, individual selection of conveyors motion parameters is required for each possible configuration of object dimensions.
Safety of single-channel control systems implemented in reversible logic
Authors: Pniewski Roman , Dobrzański Michał
Published: March 2019

The article discusses the method of controlling the correct operation of a control system using reversible gates developed by the authors. Reversible logic allows you to build fault-tolerant digital systems. The authors proposed an improved control method with a dynamic change of control signals, which can significantly improve safety.
Verifying the methodology for speed of ratio changes of continuously variable transmission of a hybrid drivetrain
Authors: Radzymiński Bartosz , Goszczak Jarosław
Published: March 2019

The article presents a test stand used to check the possibility of using a series-produced JATCO CVT7 continuously variable transmission for operating a mechanical energy accumulator which is a secondary energy source of a prototype hybrid drive system.
Problems of construction and operation of modern isothermal and refrigerated bodies
Authors: Rochatka Tomasz
Published: March 2019

The article presents a description of the structure of isothermal and refrigeration bodies, their sensitivity to mainly mechanical damage and examples of various types of damage. Presenting damage to the body, the mechanism of creation is described, damage is shown using thermographic images and the consequences of these damages are discussed. The article contains a description of the methods of examination of body damages, presenting the advantages and disadvantages of the test methods. The test results can be the basis for making a decision about further operation or qualification for repair.
Measurement of Peltier modules using the Arduino platform
Authors: Sadowski Emil , Pniewski Roman
Published: March 2019

The article discusses the system for measuring Peltier thermoelectric modules using the Arduino platform based on the Atmega328P microcontroller. The results of such measurements for the TEC1-12705 series of thermoelectric cells are also presented. Both for cooling mode operation (Peltier effect) and for working as a thermoenergy generator (Sebeecka effect)..
Types of operating data in Rail Traffic Control Systems
Authors: Ulatowski Bartłomiej , Łukasik Zbigniew , Kurkowski Alfred
Published: March 2019

This article discusses the issues of operating data in national and European Rail Traffic Control systems, i.e. in the ERTMS / ETCS and SRK systems. The article presents the possibilities and limitations of ERTMS systems. General principles of system implementation are also given, as well as specific functional levels of the Rail Traffic Control System are presented. The article describes and presents operational data related directly to the railway systems, which are based on the standard described in document E-1758. The article draws attention to the complexity of Rail Traffic Control processes, as well as the fact that it is necessary to modernize solutions that in the coming years will be a real challenge for the railway industry..
Analysis of failure of suspension devices
Authors: Ciecieląg Jan , Wiśniewski Marek
Published: March 2019

The article discusses the operational problems of the flue gas desulphurisation installation in a coal-fired power plant for hard coal.