bluuebunny/crossref_metadata_2025 huggingface dataset:
Hematological Abnormalities in Patients With COVID-19: An Emerging Approach to Differentiate Between Severe COVID-19; Compared With NonSevere Forms of the Disease
Authors: Mehrpouri Mahdieh
Published: March 2021

The 2019 novel coronavirus (2019-nCoV) or the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has emerged as a pandemic threat from December 2019. Coronavirus can cause varying degrees of illness that range from mild to severe or fatal disease. The exact mechanism on hematopoiesis induced by this coronavirus is not yet well understood, but scientific evidence indicates that COVID-19 can cause hematological changes in infected patients. The present study summarized pieces of literature regarding hematologic findings of COVID-19 and their correlation with disease severity. Finally, we offered some laboratory abnormalities which help to differentiate severe COVID-19 from non-severe forms of the disease. Among hematological parameters, decreased hemoglobin rather than anemia, leukocytosis, lymphopenia, neutrophilia, and thrombocytopenia have been observed in conducted studies in some patients with COVID19. Furthermore, as the disease progresses to severe COVID-19, hemoglobin decline, leukocytosis, lymphopenia, neutrophilia, and thrombocytopenia continue to exacerbate. In addition, the neutrophil-tolymphocyte ratio is also considered as an independent risk factor for severe infection in COVID-19 patients.
Cyto-Morphological Correlation of Indeterminate C3 (Atypical) and C4 (Suspicious) Categories in Fine Needle Aspiration Cytology of the Breast
Authors: Nutan Dixit , Kumar Bansal Vikas , Rajni Bharti , Priyam Sharma
Published: March 2021

In 1996, to harmonize the reporting system of breast lesions on fine-needle aspiration cytology (FNAC), National Cancer Institute (NCI) proposed five categories from C1-C5. C3 and C4 categories are noted to be ambiguous during histopathological correlation, hence “grey-zoned.” There have been limited researches regarding its usefulness and its histopathological correlation. This study was undertaken to evaluate C3 and C4 categories and to correlate with histopathological examination. This perspective and retrospective study was undertaken for two years. Forty cases of C3 and 32 cases of C4 were retrieved from a total of 602 cases of breast FNAC. Histopathological follow-up and correlation were available in 30 cases of C3 and 15 cases of category C4 and were selected for further study. On the histopathological correlation of the C3 category, 22 (73.3%) cases turned out to be benign, and 8 (26.7%) cases revealed malignant diagnosis, and among the C4 category, 2 (13.3%) cases revealed benign findings, and 13(86.7%) of the cases showed malignancy. This difference was statistically significant (P<0.001). The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the C4 category in the diagnosis of malignancy were 61.9%, 91.6%, 86.6%, and 73.3%, respectively. FNAC is a simple, rapid, cost-effective, and accurate method to diagnose easily accessible breast swellings. However, one should be aware of its limitations as well. Our study supports maintaining C3 and C4 categories, as there was a statistically significant difference in benign & malignant diagnosis for these categories.
Personality Disorders and Unhealthy Lifestyle: A Cross-Sectional Study
Authors: Mohammadi Mohammad Reza , Pourdehghan Parandis , Mostafavi Seyed-Ali , Hooshyari Zahra , Alavi Seyyed Salman , Khaleghi Ali , Ahmadi Ameneh , Mahmoudi-Gharae Javad , Fadaei Fooladi Mahbod , Akbarpoor Sepideh , Mobini Malihe
Published: March 2021

Personality disorders (PDs) would be associated with an unhealthy lifestyle. To date, however, there have not been sufficient studies on the relationship between them. This study aimed to investigate the association between personality disorders and an unhealthy lifestyle by using an analytical cross-sectional study. We selected 1538 married women based on the multistage cluster sampling method. We used the Millon Clinical Multiaxial Inventory (MCMI) and Lifestyle Questionnaire (LSQ). Apart from descriptive statistics, a one-sample t-test, multivariate analysis, and structural equation modeling were used. Analysis of the data suggested that negativistic (β= -0.321), schizotypal (β= -0.285), schizoid (β= -0.159), borderline (β= -0.136), melancholic (β= -0.079) PDs had a significant association with an unhealthy lifestyle, respectively. Cluster A personality disorders were prone to an unhealthy lifestyle more than the other two clusters.
A Young Man Suspicious for Cushing's Syndrome With Coronavirus Disease-19 (COVID-19): A Case Report
Authors: Besharati Shahin , Abbaspourrad Zahra , Chiti Hossein , Parsamanesh Negin
Published: March 2021

The 2019 global Coronavirus syndrome pandemic (COVID-19) has entered more than two hundred countries around the world, involving <82 million persons and >1,800,000 deaths (until January, 1st 2021). We report on COVID-19 infection in the context of a Cushing's syndrome (CS) from Iran. A 36-year-old man with proximal myopathy, plethora, and striae with central obesity was evaluated for Cushing's syndrome. During the high dose dexamethasone test, the patient developed symptoms of cough, low-grade fever, and weakness then was admitted to the ICU with a diagnosis of COVID-19. Despite treatment according to national protocols for COVID-19, the patient unfortunately died. In this report, we intend to discuss the various aspects of Cushing's syndrome and severe COVID-19 infection.
A Case of Ovarian Torsion Which Led to Abortion
Authors: Rasekhjahromi Athar , Goodarzi Sahand , Kalani Navid
Published: March 2021

Ovarian torsion occurs in 10%-22% of pregnant women, and miscarriage occurs in 11%-22% of all pregnancies, both of which are known as gynecological emergencies. The simultaneous occurrence of these two cases is rare. The present study reports a case of ovarian torsion and simultaneous abortion. In this case report, we present a 28-year-old woman in her third pregnancy with a history of two miscarriages. She was referred with an 18-week triplet pregnancy, vaginal pain and bleeding from the previous day, and colic abdominal pain with five episodes of nausea and vomiting. Upon admission to the hospital, despite performing cerclage at 13 weeks, labor pains begin, and 15 minutes later, the amniotic sac ruptures, and all three fetuses are expelled. Due to the persistence of colic pain and moderate tenderness in the lower right quadrant of the abdomen, pelvic ultrasound is reported, which shows an increase in echo parenchyma and the size of the right ovary compared to the left ovary. Doppler ultrasound showed decreased ovarian blood flow, which led to laparotomy with suspected ovarian torsion. The right ovarian peduncle had complete torsion, and the ovary appeared dark. The peduncle of ovarian torsion was opened and preserved. The patient was discharged two days after surgery and after re-color Doppler ultrasounds, which indicated ovarian blood flow.
Socioeconomic inequality in prevalence of cigarette and Water-pipe smoking among Iranian adults: A blinder- Oaxaca decomposition Analysis
Authors: Nemati Saeed , Rafei Ali , Mehrtash Hedieh , Freedman Neal D. , Fotouhi Akbar , Zendehdel Kazem
Published: March 2021

Background: To assess the association between socioeconomic inequality and the prevalence of tobacco smoking among Iranian adults in 2010.
Methods: Data from the fifth national STEPS survey (WHO STEPwise approach to NCD Surveillance) were analyzed. A Blinder-Oaxaca decomposition method was applied to assess the association between socioeconomic inequality and the prevalence of daily cigarette and water pipe (WP) smoking among Iranian men and women.
Results: From 10,615 participants in the survey, 4,203 (39.5%) participants appeared to be in the first and fifth quintiles of socioeconomic status (SES). For men, the prevalence of daily cigarette smoking was higher among those with low SES (23.1%) than those with high SES (11.1%) (P<0.001). The observed difference was mainly attributed to the educational level (8.6%). We found no significant difference in high compared to low SES women for cigarette smoking (P value= 0.881). Although there was no difference between high and low SES men for daily WP smoking, low SES women had a higher prevalence of WP smoking (4.4%) than high SES women (1.3%) (P value=0.027). Education level was the major factor (3.3%) to explain the corresponding difference. The difference in WP smoking in high and low SES men was not statistically significant (P value= 0.199).
Conclusion: Cigarette smoking in men and WP smoking in women are associated with SES in Iran. Education was the main factor explaining the differences in the prevalence of cigarette and WP smoking in Iranian men and women. Results from this study must be considered as a pivotal basis for designing a tobacco control program at national and sub-national levels.
Metformin Efficacy on Proliferation Indices of Tumoral Cells in Non-Diabetic Patients with Invasive Breast Cancer Referring to the Cancer Institute of Iran
Authors: Sadighi Sanambar , Saberian Maasoumeh , Behrouzi Bita , Najafi Massoome , Jahanzad Issa , Omranipour Ramesh
Published: March 2021

Background: Because of the decreasing effect of metformin on insulin resistance, it has been suggested as an anti-obesity and anti-cancer drug. So, we aimed to study the effect of metformin therapy on tumor cell proliferation in non-diabetic breast cancer patients.
Methods: We conducted a prospective clinical trial and studied the effect of metformin therapy on the level of Ki67 as a measure of tumor cell proliferation. Our primary endpoint was to evaluate the changes in Ki67. The intervention group consisted of 25 non-diabetic breast cancer patients with no indication for neoadjuvant chemo- therapy. They were followed up from the time of biopsy to operation. Metformin (1500 mg/day) was prescribed in the intervention group from the date of diagnosis until the surgery (2.8 weeks). Controls were 20 early breast cancer patients who had been followed up with no prescription from biopsy until operation.
Results: We could not find any statistically significant difference between the two groups regarding baseline clinical or tumor characteristics such as age, stage, grade, estrogen receptor, HER2 status or time, and type of surgery. However, the immuno- histochemistry (IHS) study showed a decrease in median Ki67 from 35.14 to 29.6 in the intervention group (P-value= 0.02). While an increase from 24.5 to 30.6 was detected in the control group (P-value= 0.02). Both of these changes were statistically significant. Although mild gastrointestinal symptoms were seen in approximately 50% of cases, generally, patients tolerated metformin well. There was a correlation between the score of HOMA, a metabolic factor, and the changes in KI67.
Conclusion: Metformin prescription in a short period of time between biopsy and definitive surgery leads to the inhibition of breast cancer cell growth. We found a relationship between metformin anti-proliferative effect and glucose and insulin metabolism.
Common Presenting Signs and Symptoms in Children with Acute Lymphoblastic Leukemia
Authors: Shahverdi Ehsan , Shahriari Mehdi , Zare Soonia , Rahimine- jad Mohammad Saeid , Hosseinpour Soleimani Fatemeh , Maki Massoumeh , Manouchehri Rojen , Haj Abdo Mourad
Published: March 2021

Background: Acute lymphoblastic leukemia (ALL) is one of the blood cancers responsible for 80% of children’s leukemia and is also the most common malignancy in patients aged under 14 years (frequency of 23% among all types of cancers). Regarding the importance of identifying clinical symptoms to diagnose the disease in the early stages, this study is conducted to investigate the symptoms at diagnosis in ALL children.
Methods: In this retrospective cohort study, 350 patients aged under 14, referring to four hospitals of Shiraz University of Medical Sciences as reference hospitals in Southern Iran, participated between 2013 and 2019. Their information was collected using patients’ records, and the data were analyzed using SPSS version16.
Results: Based on the findings of this study, the first clinical manifestations of the disease happened suddenly and acute, occurring within a few days to a maximum of 6 weeks before diagnosis. Fever (70%) and hepatomegaly (60%) were the most common signs and symptoms in patients. However, a significant percentage of ALL patients referred with non-specific symptoms.
Conclusion:The results of this study indicate the importance of recognizing common and unusual signs and symptoms based on a complete and thorough history taking and accurate physical examination as well as rare symptoms that may be ignored or misdiagnosed by physicians. The knowledge of common signs and symptoms results in early diagnosis of the disease in early stages.
Inutility of IMP3 Marker in Differentiating Hodgkin Lymphoma from Large Cell Lymphoma
Authors: Mehrjerdi Ali Zare , Ahmadi Mahdie
Published: March 2021

Background: Hodgkin’s lymphoma is one of the most commonly diagnosed lym- phomas in Western society. Today Reed-Sternberg cells are identified by positive staining of several biomarkers. The IMP3 (insulin-like growth factor II m-RNA-bind- ing protein 3) marker is a member of the insulin-like growth factor II mRNA binding protein family that has been suggested as a diagnostic marker in some epithelial malignancies. In this study, we aimed to evaluate the expression profile of IMP3 in Hodgkin’s lymphoma patients and compare it with those with large cell lymphoma.
Methods: In this study, patients diagnosed with Hodgkin’s lymphoma between 2016 and 2018 were recruited. For the control group, patients diagnosed with large cell lymphoma were chosen. Paraffin blocks were collected and cut by a microtome machine. Immunohistochemical staining was performed on the slides for the IMP3 marker, using the Envision method. The color intensity was divided into four groups, and data on age, gender, staining intensity, sampling rate, and staining pattern en- tered at the end of the checklists. The collected data were analyzed using SPSS 19 software. The paired t-test has was employed, and a significant statistical level of 0.05 was considered in all tests.
Results: In this study, 145 patients in a wide range of 5 to 84 years (the mean age = 41 ± 17 years) were studied. Fifty-three patients were diagnosed with diffuse large B-cell lymphoma (36.6%), 4 cases (2.8%) with anaplastic large cell lymphoma and 88 cases with (60.7%) Hodgkin’s lymphoma. Among 145 patients in the current study, 143 patients (98.6%) were positive for IMP3. IMP3 was positive in all patients with Hodgkin’s lymphoma and anaplastic large cell lymphoma, and only 2 cases of diffuse large B-cell lymphoma were negative for this maker, in whom severe ne- crosis was noted. Consequently, there is not a vivid difference between Hodgkin’s lymphoma and non-Hodgkin’s lymphoma (p-value=0.153)
Conclusion: The marker is positive for Hodgkin’s lymphoma with a negative back- ground and may be used as a supplementary marker along with CD15 and CD30 to detect neoplastic cells. However, it cannot help differentiate it from large cell lym- phomas because it is also positive for non-Hodgkin lymphomas.
The Effect of Piperine on MMP-9, VEGF, and E-cadherin Expression in Breast Cancer MCF-7 Cell Line
Authors: Zare Zahra , Nayerpour Dizaj Tina , Lohrasbi Armaghan , Sheikhalishahi Zakieh Sadat , Panji Mohammad , Hosseinabadi Fahimeh , Najafi Vajiheh , Abazari Omid , Abbasi Mojtaba , Khanicheragh Parisa
Published: March 2021

Background: Vascular endothelial growth factor (VEGF), matrix metalloproteinase-9 (MMP-9), and E-cadherin play a vital role in the behavior of angiogenesis, metastasis, and invasion of breast tumor cells. Piperine, the main component of Piper Nigrum, has shown anti-cancer properties in various malignancies. This Study investigates the potential effect of piperine on MMP-9, E-cadherin, and VEGF expression in breast cancer MCF-7 cell line.
Methods: MTT assay was applied to assess the viability of MCF-7 cells. The mRNA levels of MMP-9, VEGF, and E-cadherin were assayed by qRT-PCR. Western blot was performed to identify the protein level of MMP-9.
Results: MTT assay results showed that piperine treatment (5, 10, 25, 50, 75, and 100 μM) for 24 hours effectively inhibited cell viability of MCF-7 cells as compared with the control group. Furthermore, the gene expression of VEGF, MMP-9, and E-cadherin was dose-dependently suppressed by piperine treatment (5, 10 and 25 μM) (P<0.05; P<0.01). The results also indicated that piperine (5, 10, and 25 μM) significantly suppressed MMP-9 protein expression after 24 hours of piperine treatment (P<0.01).
Conclusion: These results suggest that piperine may prevent angiogenesis, migration, and invasion of MCF-7 cells by suppressing MMP-9 and VEGF, and by inducing E-cadherin expression. Hence, it may be a suitable candidate for designing new drugs in cancer therapy.
Evaluation of Different Types of Pain in Patients with Breast Cancer
Authors: Fakhim Sanaz , Farahani Sepideh , Pourkarim Hoda , Mousavi Fateme , Ahmadi Mohammad Hossein , Azad Mehdi
Published: March 2021

Background: Cancer, a common disease in the world, is considered the second cause of mortality in developed countries. In the management of symptoms created by breast cancer (BC), pain is the most important. So, this study aimed to evaluate different dimensions of pain in patients using the McGill Pain Questionnaire. In this way, physicians could perform effective treatment for patients.
 
Methods: This case study was done on BC patients aged 30-60 years old in some specialized cancer hospitals in Tehran. The utilized research instrument in this study was the McGill Pain Questionnaire. Data were analyzed by SPSS Software.
Conclusion: According to these results, it is possible to use effective and better treatment to reduce BC patients’ pain.
Evaluation of Peritoneal Lavage for Gastric Cancer Staging in Patients Without Ascites Based on Cytology and Carcinoembryonic Antigen
Authors: Elyasinia Fezzeh , Karimian Faramarz , Samiei Fatemeh , Sadeghian Ehsan
Published: March 2021

Background: Imaging, cytological examination of ascites (if present), laparosco- py, and peritoneal lavage are performed before surgery for gastric cancer staging. Peritoneal lavage aims to diagnose the microscopic presence of tumor cells on the peritoneal surface. Positive cytology may have a prognostic value that classifies the disorder as stage IV, in which the patient is no longer an elective surgical candidate. Thus, our study was designed to assess the ability of peritoneal lavage to stage gastric cancer in non-ascitic patients based on cytological evaluation and carcinoembryonic antigen (CEA) level measurement.
Methods: In our prospective study, we examined gastric cancer patients who were candidates for elective surgery. Upon entering the abdominal cavity and before tu- mor manipulation, normal saline (500 ml) was applied, and the abdominal cavity was thoroughly dispersed. After three minutes, the fluid was drained and addressed to cytological analysis and CEA measurement by radioimmunoassay (RIA). Study var- iables including age, sex, family history, tumor position, pathology, staging, grading, the original tumor size, regional lymph node involvement, and distant metastases were recorded during the pre- and postoperative staging. The association between positive peritoneal lavage cytology and various patients’ characteristics was investigated.
Results: In this study, 94 patients were screened. Due to lymphoma and gastrointes- tinal stromal tumor (GIST), two patients were excluded. We examined 92 patients, including 63 males (68.5 %) and 29 females (31.5 %). The mean age of patients was 58.52 ± 11.87 years. The most common tumor location was the esophagogastric junction. Moderately differentiated adenocarcinoma was the most frequent micro- scopic diagnosis. T3 was the most prevalent primary tumor size in 51 patients. Sev- enty-two patients (78.26%) were operable, of whom 18 (19.6 %) were positive for peritoneal lavage cytology. Positive cytology of peritoneal lavage was significantly related to tumor size, tumor grade, serosa/adjacent organ invasion (T4), laparoscopic staging findings, locally advanced disease (R0), and stage of the disease (P < 0.05). In the peritoneal lavage fluid, elevated CEA titers were significantly related to the high-grade tumor (P = 0.012). 
Conclusion: Our study demonstrated that positive cytology and high CEA titers in peritoneal lavage fluid of gastric cancer patients without ascites are significantly correlated to the advanced stages.
Giant Cell Variant of Glioblastoma Multiforme: Report of a Rare Variant in a Child
Authors: Aminparast Zahra , Ramezani Mazaher
Published: March 2021

Malignant glial tumors are rare in children. Giant cell variant is a rare subtype of glioblastoma, accounting for about 0.8% of brain tumors and 5% of glioblastoma tumors. Giant cell glioblastoma is a male predominant tumor in children and adults. Due to the low prevalence of this variant, available information is limited. An 11-year-old female child was referred with a chief complaint of a progressive persistent headache. MRI showed a well-defined cystic lesion with a solid mural component in the right parietal lobe with a compression effect on the ipsilateral ventricular system. Surgery was done. After the pathologist reported glioblastoma multiforme, a giant cell variant, the patient received 30 sessions of radiation therapy. The patient was readmitted 18 months later with a headache, and the pathologist confirmed the recurrence of the tumor. Based on radiology, the giant cell glioblastoma cannot be distinguished from the common subtype glioblastoma. The pathologists must be aware of this entity, and histologic differential diagnoses are warranted for diagnostic, prognostic, and therapeutic purposes.
Limitation of Experimental Research on Opium Consumption and Cancer Development in Human: Call for Establishment of an International Consortium
Authors: Zendehdel Kazem
Published: March 2021

The article's abstract is not available.
Effect of 6 Weeks of Aerobic Training on the Oxidative Stress Condition of Male Wistar Rats Exposed To Particulate Matter
Authors: Eshaghi Zahra , Habibi Abdolhamid , Fatemi Tabatabaei Seyed Reza , Goudarzi Gholamreza
Published: March 2021

Introduction: Scientific evidence suggests the role of environmental pollutants, especially particulate mater in oxidative stress. However, the regular aerobic training has an important role in enhancing antioxidant defense and resistance to oxidative stress. Therefore, the purpose of this study was to investigate the effect of 6 weeks of aerobic training on the oxidative stress condition of male Wistar rats exposed to particulate matter.
Methods: In this experimental study, 32 male rats (245 ± 8.5 g) aged 10 weeks, were divided into 4 groups of 8 rats each. The rats received the infusion of the particulate matter for 6 weeks through the nose. The exercise program included 6 weeks of aerobic training with 50% of maximum exercise; at the end of 6 weeks of the program, 24 hours after the last exercise session, blood samples were taken. Descriptive one-way analysis of variance (ANOVA) was used in different groups. If analysis were significant, differences between groups were estimated using LSD test. Significance was defined as P≤0.05. Statistical analysis was performed using SPSS software version 16.
Results: After 6 weeks of aerobic training, levels of Malondialdehyde in both groups: healthy exercise and particulate matter+exercise decreased significantly and in the infected group (P≤0.05), but did not show significant difference compared to the control group (P≥0.05). The level of Superoxide dismutase in the infected group showed a significant increase. There was no significant difference between the two Glutathione peroxidas and catalase enzymes in each group (P≥0.05).
Conclusion: Based on the results, it can be concluded that aerobic training may be effective in reducing lipid peroxidation and enhancing antioxidant defense.
Effect of Voluntary Training after the Induction of Experimental Autoimmune Encephalomyelitis on Some Myelin-Producing Proteins in Female C57BL/6 Mice
Authors: Honarmandnasab Yasaman , Kordi Mohammad Reza , Gaeini Abbas Ali
Published: March 2021

Introduction: The aim of the present study was to investigate the effect of voluntary training period after the induction of experimental autoimmune encephalomyelitis (EAE) on some myelin-producing proteins in C57BL/6 female mice.
Methods: In this experimental study first 28 mice, which were 6-8 weeks old, were purchased and were randomly divided into three groups. Exercise activity (n=12), healthy control (n=8) and experimental autoimmune encephalomyelitis (EAE) control (n=8). Voluntary exercise group did exercises, 1 hour, 5 days a week for 4 weeks after induction of EAE and having the clinical score one for two days in a row. 48 hours after final exercise section, the mice were killed and immunohistochemistry was used to evaluate the expression of MBP and CNPase proteins. Using SPSS version 16 software, multiple analysis of variance and LSD post hoc test were used to examine the groups' data differences.
Results: The results showed that the expression of both proteins as a result of voluntary exercise had a significant increase in the exercise group compared to the EAE control group ( p<0.05).( in White Matter: MBP, Wheel Running and Control EAE, P= .017; Wheel Running and Healthy Control, P= .001; CNPase, Wheel Running and Control EAE, P= .015; Wheel Running and Healthy Control, P= .000; in Gray Matter: MBP, Wheel Running and Control EAE, P= .000; Wheel Running and Healthy Control, P= .000; CNPase, Wheel Running and Control EAE, P= .005; Wheel Running and Healthy Control, P= .001.
Conclusion: Voluntary exercise may have a positive effect on increasing myelination in treatment and control of MS.
EVASÃO DO CURSO DE PÓS-GRADUAÇÃO EM GESTÃO DE NEGÓCIOS DE UNIVERSIDADE CORPORATIVA: PERCEPÇÕES DO ESTUDANTE/EMPREGADO
Authors: Pereira Marcelo Almeida de Camargo , Rosa Luciane de Fátima Giroto , Felicetti Vera Lucia
Published: March 2021

A pós-graduação em Gestão de Negócios é uma realidade e inovação na educação corporativa da instituição federal pesquisada, que, por motivos de segredo industrial não será revelada. O curso apresenta características inerentes à educação a distância (EaD), como distância no espaço e tempo e a autonomia do aluno. Com relação aos alunos dessa modalidade de ensino, torna-se importante identificar os motivos que levaram muitos deles a evadirem-se do curso. Para tanto, foi aplicado um instrumento de pesquisa cujo objetivo geral foi identificar quais razões levaram o estudante, que é empregado da empresa, a se evadir desse curso. O instrumento, de caráter quantiqualitativo, continha questões fechadas com respostas a partir da escala Likert, para análise estatística descritiva inferencial, e uma questão aberta, em que foi utilizada a técnica de análise textual discursiva. Evidenciou-se que os motivos que levaram ao elevado número (41%) de evadidos no curso estão relacionados com: conciliação do tempo para as atividades de trabalho e a necessidade da presença nas atividades síncronas (aulas por videoconferência e provas); necessidade de maior articulação da universidade corporativa da empresa com os gestores dos empregados, no sentido de facilitar a participação destes nas atividades presenciais; sensibilização quanto aos aspectos trabalhistas, como férias e especificidades da realidade da empresa, como contingências e greves, entre outros fatores.
DESENVOLVIMENTO DE HABILIDADES DE LEITURA MULTILETRADA NAS AULAS DE GEOGRAFIA: UM RELATO DE EXPERIÊNCIA
Authors: Leite da Silva Carvalhaes Vinicius , Ramos de Andrade Maria de Fátima , Moço Aparício Ana Sílvia
Published: March 2021

Desenvolver atividades que explorem diversos gêneros textuais, na perspectiva dos multiletramentos, tem sido muito valorizado no contexto escolar. Hoje, além de textos escritos, somos obrigados a extrair informação e conhecimento de imagens, gráficos, tabelas, músicas, animações etc., que exigem um preparo diferenciado tanto do professor quanto dos alunos. O presente artigo tem como objetivo investigar as habilidades de leitura de textos multissemióticos que podem ser desenvolvidas em alunos do ensino médio. Como objetivo específico tem-se a aplicação de uma sequência didática cuja intenção é trabalhar com mímica e desenho a fim de desenvolver habilidades de leitura que sejam necessárias para a resolução de questões-problema dentro da perspectiva dos multiletramentos. Percebe-se que, além de engajamento e dedicação, os alunos envolvidos na atividade desenvolveram habilidades de leitura que não são restritas apenas ao universo do texto escrito.
A ARQUITETÔNICA EM “UM DIA, UM RIO”
Authors: Dos Santos Oliveira Andreia , Guizelim Simões Girotto Cyntia Graziella , Russo Daniele Aparecida
Published: March 2021

A arquitetônica, entendida neste artigo como a forma como o discurso se constrói e se estrutura, de modo que material, forma e conteúdo se integrem (GEGE, 2009), é fundamental na análise do livro escrito por Leo Cunha e ilustrado por André Neves Um dia, um rio. Por isso acredita-se que seja relevante para os leitores dessa obra ilustrada conhecer a sua arquitetônica para que possam a ela atribuir sentidos durante o ato cultural de ler. A concepção adotada de arquitetônica é aquela que compreende a obra como objeto cultural artístico (GEGE, 2009), e por esse motivo propõe-se a leitura do texto artístico como um todo integrado em que os seus elementos constitutivos são essenciais para a produção de sentidos. A análise elaborada permite afirmar que Um dia, um rio, constituído por linguagem híbrida e inovadora, pode ser classificado como obra vanguardista, já que rompe com os modelos tradicionais e revela as contradições e conflitos da sociedade atual. Este artigo está ancorado nos pressupostos teóricos de Bakhtin (2002, 2011) e seus estudiosos, Cadermatori (2010), Zilberman (2003), Lindem (2018), Arena (2010), entre outros.
Disease-associated genetic variants in the regulatory regions of human genes: mechanisms of action on transcription and genomic resources for dissecting these mechanisms
Authors: Ignatieva E. V. , Matrosova E. A.
Published: March 2021

Whole genome and whole exome sequencing technologies play a very important role in the studies of the genetic aspects of the pathogenesis of various diseases. The ample use of genome-wide and exome-wide association study methodology (GWAS and EWAS) made it possible to identify a large number of genetic variants associated with diseases. This information is accumulated in the databases like GWAS central, GWAS catalog, OMIM, ClinVar, etc. Most of the variants identified by the GWAS technique are located in the noncoding regions of the human genome. According to the ENCODE project, the fraction of regions in the human genome potentially involved in transcriptional control is many times greater than the fraction of coding regions. Thus, genetic variation in noncoding regions of the genome can increase the susceptibility to diseases by disrupting various regulatory elements (promoters, enhancers, silencers, insulator regions, etc.). However, identification of the mechanisms of influence of pathogenic genetic variants on the diseases risk is difficult due to a wide variety of regulatory elements. The present review focuses on the molecular genetic mechanisms by which pathogenic genetic variants affect gene expression. At the same time, attention is concentrated on the transcriptional level of regulation as an initial step in the expression of any gene. A triggering event mediating the effect of a pathogenic genetic variant on the level of gene expression can be, for example, a change in the functional activity of transcription factor binding sites (TFBSs) or DNA methylation change, which, in turn, affects the functional activity of promoters or enhancers. Dissecting the regulatory roles of polymorphic loci have been impossible without close integration of modern experimental approaches with computer analysis of a growing wealth of genetic and biological data obtained using omics technologies. The review provides a brief description of a number of the most well-known public genomic information resources containing data obtained using omics technologies, including (1) resources that accumulate data on the chromatin states and the regions of transcription factor binding derived from ChIP-seq experiments; (2) resources containing data on genomic loci, for which allele-specific transcription factor binding was revealed based on ChIP-seq technology; (3) resources containing in silico predicted data on the potential impact of genetic variants on the transcription factor binding sites.
Crop pangenomes
Authors: Pronozin A. Yu. , Bragina M. K. , Salina E. A.
Published: March 2021

Progress in genome sequencing, assembly and analysis allows for a deeper study of agricultural plants’ chromosome structures, gene identif ication and annotation. The published genomes of agricultural plants proved to be a valuable tool for studing gene functions and for marker-assisted and genomic selection. However, large structural genome changes, including gene copy number variations (CNVs) and gene presence/absence variations (PAVs), prevail in crops. These genomic variations play an important role in the functional set of genes and the gene composition in individuals of the same species and provide the genetic determination of the agronomically important crops properties. A high degree of genomic variation observed indicates that single reference genomes do not represent the diversity within a species, leading to the pangenome concept. The pangenome represents information about all genes in a taxon: those that are common to all taxon members and those that are variable and are partially or completely specif ic for particular individuals. Pangenome sequencing and analysis technologies provide a large-scale study of genomic variation and resources for an evolutionary research, functional genomics and crop breeding. This review provides an analysis of agricultural plants’ pangenome studies. Pangenome structural features, methods and programs for bioinformatic analysis of pangenomic data are described.
„Gorsze jest wrogiem złego”, czyli „naprawianie” błędów legislacyjnych na przykładzie regulacji dotyczącej podatku od wyjścia
Authors: Nowak-Piechota Aneta
Published: March 2021

Celem artykułu jest ocena wprowadzonego do polskiego systemu prawnego w 2019 r. podatku od wyjścia od osób fizycznych, z uwzględnieniem przede wszystkim modelu jego płatności. To właśnie ten element konstrukcji exit tax ma najistotniejsze znaczenie dla ustalenia zgodności całej analizowanej regulacji z prawem Unii Europejskiej oraz zasadami i wartościami konstytucyjnymi. W tym zakresie na szczególną uwagę zasługuje Rozporządzenie Ministra Finansów z dnia 27 czerwca 2019 r. przedłużające termin płatności podatku od wyjścia w przypadku osób fizycznych, stanowiące przykład wyjątkowo nieudanej i prawnie wadliwej próby „naprawiania” wcześniejszych błędów ustawodawcy.
Von der Novellistik zur Equilibristik. Literaturkritische Wahrnehmung der Prosa von Franziska zu Reventlow von ihrem Debüt als Romanautorin 1904 bis 1927
Authors: Górny Justyna
Published: March 2021

In der Kritik und in der Literaturwissenschaft des ausgehenden 19. Jh. wurde das schriftstellerische Schaffen von Frauen meistens im Zusammenhang mit ihrem Geschlecht gelesen, was bedeutet, dass in den Besprechungen ihrer Texte die ‚Weiblichkeit‘ problematisiert wurde. Es bedeutet aber nicht immer, dass die Literaturkritik die Texte von Frauen dadurch abwerten wollte. Auch die Rezensenten der Prosa von Franziska zu Reventlow (1871-1918) waren bemüht, eine positive Interpretation, die die ‚Weiblichkeit‘ einbezieht, zu entwickeln. Die ausgrenzende Potenz dieser Betrachtungsweise wird erst aus dem zeitlichen Abstand bemerkbar: Die Fixierung auf die ‚Weiblichkeit‘ der Autorin hatte zur Folge, dass in den Rezensionen keine Interpretationsmuster für Reventlows Texte ausgearbeitet wurden, die dann durch die literaturwissenschaftliche Forschung hätten übernommen oder auch dekonstruiert werden können. Außerdem wurde durch das ständige Hinweisen auf das Geschlecht der Autorin der Schwerpunkt des Interesses auf den biographischen Aspekt verlagert. Die Biographie wiederum wurde nicht etwa als Rohmaterial für die Prosa, sondern als deren Inhalt und Wesen aufgefasst.
Ulanen und Stahlhelden. Konstruktion der polnischen und deutschen militärischen Männlichkeit im Kontext des Ersten Weltkrieges
Authors: Szczepaniak Monika
Published: March 2021

Der Beitrag unternimmt einen ersten Versuch, Ähnlichkeiten und Unterschiede in der Konstituierung der deutschen und polnischen militärischen Männlichkeit im breit gefassten kulturellen Kontext des Ersten Weltkrieges zu erkennen. Das Grundanliegen bezieht sich auf das Problem der allgemeinen Militarisierung von Männlichkeit und die Konstruktion eines ‚harten‘ Maskulinismus, der unter den Bedingungen der Männlichkeitskrise in Deutschland dominierte und im polnischen Raum, wo man auf die so genannte „goldene Zeit“ (STANISŁAW DŁUGOSZ 1917) hoffte, wohl keine bedeutende Rolle spielte. Die hegemonialen Paradigmen des polnischen verwegenen Ulanen einerseits und des deutschen Stahlhelden andererseits werden am Beispiel von literarischen Texten diskutiert, die die jeweils erwünschte Männlichkeitsvariante des kämpfenden Helden ideologisieren. Hingewiesen wird aber auch auf literarische Versuche, diese Paradigmen zu dekonstruieren.
Konfrontative Textlinguistik am Beispiel deutscher und polnischer Vereinssatzungen
Authors: Czachur Waldemar
Published: March 2021

Das Ziel des vorliegenden Beitrags ist es, einige Aspekte des Vergleichs der Textmuster Satzung im Deutschen und Polnischen zu diskutieren. Nach der Darstellung der grundlegenden Begriffe der Textlinguistik werden Aufgaben der konfrontativen Textlinguistik ausgearbeitet, auf deren Grundlage die Analyse der Vereinssatzungen im Deutschen und Polnischen erfolgt. Untersucht wird die Funktion der Textsorte Satzung im Verwendungskontext, insbesondere ihre Struktur und die sprachlichen Mittel, die die Normativität in den Satzungen beider Sprachen ausdrücken.
Sentimen Analisis Twitter Terhadap Isolasi Diri Masyarakat Indonesia Akibat Dampak Covid-19
Authors: Taufan Resi
Published: March 2021

Maraknya penyebaran virus Corona atau Covid-19 di Indonesia mengakibatkan pemerintah menganjurkan agar masyarakat indonesia melakukan isolasi diri dan social distancing. Hal ini menyebabkan banyaknya tanggapan publik khusunya di media sosia twitter tentang anjuran tersebut. Dalam penelitan ini akan dilakukan analisis sentimen masyarakat terhadap dampak yang dirasakan masyarakat mengenai isolasi diri. Ada beberapa tahap untuk melakukan analisis sentimen, diantaranya adalah tahap pengumpulan data, preprocesing data, validasi data serta pengujian dilakukan dengan tools rapidminer dengan menggunakan fitur TF-IDF untuk melakukan pembobotan pada setiap kata. Pada penelitian ini setiap tweet diklasifikasikan menjadi sentimen positif dan negative. Metode Naive Bayes dalam klasifikasi sentimen memiliki akurasi yang cukup baik untuk melakukan klasifikasi sentimen.
Message from the editors
Authors: Gerrits Lasse , Morçöl Göktuğ
Published: March 2021

Complexity, Governance & Networks relaunches as an open access journal with a new publisher. We discuss the changes and consequences for readers and authors.
Intonational variation in third party complaints in Spanish
Authors: Rao Rajiv
Published: March 2021

Very little previous research has addressed the prosodic characteristics of third party complaints. This paper discusses an utterance and word level intonational analysis of this speech act in four speakers of Mexican Spanish. The effect of social distance/ power relationships was incorporated into the study by creating an experimental data elicitation task in which participants addressed identical complaints to a friend, as well as a boss, based on a series of hypothetical contexts. Major global findings revealed that all speakers significantly increased their fundamental frequency (F0) mean when directing their complaints to friends, however, only two speakers significantly expanded their F0 range in the same circumstance. Locally, peaks and valleys were manifested at significantly higher levels across the board when addressing friends. Finally, while speakers produced complaint contours of similar overall shape regardless of hearer, individual variation was present in the form of circumflex versus suppressed utterance-final F0 configurations. Overall, the relatively small data set initiated preliminary thoughts on the application of both cross-linguistic and language- and dialect-specific intonational concepts to complaints while also emphasizing the importance of relationships between interlocutors for future studies.
Probing rhythmic patterns in english-L2
Authors: Lima Junior Ronaldo Mangueira , Garcia Guilherme Duarte
Published: March 2021

Languages are traditionally classified as mora-timed, syllable-timed or stress-timed in relation to their rhythmic patterns. The distinction between syllable-timed and stress-timed languages, however, lacks solid evidence in the literature. Syllable-timed languages typically have similar duration across unstressed and stressed syllables, whereas stress-timed languages tend to have similar inter-stress intervals, and unstressed syllables are shorter than stressed syllables. According to this categorical classification, English is a stress-timed language, thus having more reduction in unstressed vowels. Brazilian Portuguese, on the other hand, is typically classified as syllable-timed, and thus has little reduction of unstressed vowels. If these categorical rhythmic differences are correct, then acquiring the rhythmic patterns of English should be a challenging task to Brazilian learners, who are not expected to produce unstressed vowels with as much reduction as English native speakers. However, recent studies have found that the typology of rhythm is best understood as not categorical, but rather gradient, and that Brazilian Portuguese has a mixed classification, with more stress timing than would be expected from a traditional and categorical perspective. We therefore hypothesize that Brazilian learners of English should not have major difficulties reducing unstressed vowels, even when exposed to the second language later in life. To test this hypothesis, we analyze production data of native speakers of English (control group) and of Brazilian advanced learners of English.
EVALUASI KINERJA UNIT FILTRASI IPA II PRAMUKA PDAM BANDARMASIH
Authors: Noor Azrian , Mahmud Mahmud , Abdi Chairul
Published: March 2021

PDAM Bandarmasih merupakan perusahaan daerah air minum yang melayani penyediaan air bersih di kota Banjarmasin. Pengolahan air bersih dituntut menghasilkan kualitas air bersih yang baik. Untuk menjaga kualitas air bersih yang baik diperlukan unit pengolahan air bersih yang memiliki kinerja yang baik. Upaya untuk menjaga kualitas produksi air bersih adalah dengan melakukan evaluasi pada unit pengolahan air minum. Penelitian ini bertujuan untuk (1) mengetahui kinerja unit filtrasi pada kondisi eksisting (2) menyelidiki permasalahan pada unit filtrasi dan alternatif perbaikan kinerja unit filtrasi. Hasil penelitian memaparkan unit filtrasi IPA II PDAM Bandarmasih berjenis saringan pasir cepat dengan dual media. Dimensi unit filtrasi memiliki panjang, lebar dan tinggi masing-masing 9,08 m; 3,8 m; 2,31. Permasalahan pada Unit filtrasi adalah kedalaman filter,ketinggian muka air,dan effectife size media pasir yang digunakan tidak sesuai dengan kriteria desain. Oleh karena itu perlu dilakukan perubahan pada ketinggian unit filtrasi dan pemilihan kembai ukuran media filtrasi.
PEMBUATAN DAN KARAKTERISASI KARBON AKTIF DARI SERBUK ARANG KAYU ULIN DENGAN AKTIVASI KOH DAN APLIKASINYA UNTUK MENURUNKAN KROM PADA LIMBAH CAIR SASIRANGAN
Authors: Wibawati Asmarika , Mahmud Mahmud , Abdi Chairul
Published: March 2021

Krom merupakan salah satu jenis logam berat yang memiliki toksisitas tinggi dan melebihi ambang batas sehingga dapat menurunkan kualitas lingkungan di perairan. Salah satu cara mengurangi kadar krom dalam limbah cair sasirangan ialah dengan adsorpsi menggunakan arang aktif sebagai absorben. Serbuk gergaji kayu ulin adalah salah satu limbah yang banyak tidak dimanfaatkan dan dapat mengganggu estetika lingkungan. Sehingga memiliki potensi sebagai bahan baku dalam pembuatan karbon aktif. Dalam penelitian ini dilakukan adsorpsi terhadap logam berat Cr menggunakan karbon aktif serbuk kayu ulin berukuran 80-100 mesh sebagai karbon aktif. Penelitian bertujuan untuk menyelidiki pengaruh variasi waktu dan molaritas terbaik terhadap besarnya efesiensi absorpsi. Dari hasil penelitian menunjukkan bahwa waktu dan molaritas yang paling efektif adalah waktu perendaman 24 jam dengan molaritas terbaik adalah 3 M. Sedangkan untuk penurunan Cr pada limbah cair sasirangan menghasilkan efesiensi adsorpsi sebesar 65 %.
EVALUASI KESESUAIAN PEMANFAATAN LAHAN UNTUK TANAMAN JERUK DI KECAMATAN ALALAK DAN KECAMATAN MANDASTANA, KABUPATEN BARITO KUALA
Authors: Lufti Cindy Priscillia , Riduan Rony , Nirtha Indah
Published: March 2021

Evaluasi lahan merupakan suatu pendekatan atau cara untuk menilai potensi sumber daya lahan. Hasil evaluasi lahan akan memberikan informasi dan atau arahan penggunaan lahan yang diperlukan, dan akhirnya nilai harapan produksi yang kemungkinan akan diperoleh.Tujuan penelitian ini adalah untuk mengidentifkasi sifat atau kualitas lahan, evaluasi kesesuaian lahan dan menyusun rekomendasi pemanfaatan lahan untuk tanaman jeruk di Kecamatan Alalak dan Kecamatan Mandastana. Penelitian ini dilakukan pada skala lapangan dan skala laboratorium. Untuk skala lapangan dilakukan pengamatan terhadap kondisi lahan, menentukan titik pengambilan sampel, tekstur tanah dan mengukur kedalaman tanah. Untuk skala laboratprium dilakukan pengamatan terhadap pH tanah, P2O5 dan C-organik. Hasil penelitian menunjukkan bahwa pada pada Kecamatan Alalak dan Kecamatan Mandastana, kondisi temperature, tekstur dan kedalaman tanahnya cukup baik sehingga masih dalam tingkat sesuai (S). Dari hasil evaluasi yang dilakukan, kondisi kesesuaian lahan menunjukkan lahan tersebut cocok untuk pemanfaatan jeruk walaupun pada Kecamatan Alalak dan Kecamatan Mandastana dapat terlihat ketersediaan air sebagai faktor pembatas.
KAJIAN FAKTOR PENDORONG KEAKTIFAN KINERJA ORGANISASI DAN PARTISIPASI MASYARAKAT DALAM PENGELOLAAN BANK SAMPAH KOTA BANJARBARU
Authors: Ummah Nailul , Mahyudin Rizqi Puteri , Firmansyah Muhammad
Published: March 2021

Bank sampah adalah tempat untuk menabung sampah yang telah dipilah terlebih dahulu sebelum disetorkan. Perkembangan bank sampah tidak terlepas dari adanya kegiatan organisasi dan peran serta masyarakat sebagai komponen terpenting dalam keberlanjutan pengelolaan bank sampah. Tujuan penelitian ini untuk mengkaji faktor prioritas yang menjadi pendorong keaktifan organisasi dan partisipasi masyarakat dalam pelaksanaan bank sampah. Empat bank sampah terbaik dalam penelitian ini yaitu bank sampah Gemilang, Kelurahan Guntung Manggis, bank sampah Sumber Rejeki, Kelurahan Syamsyudin noor, bank sampah Barokah, Kelurahan Landasan Ulin Timur dan bank sampah Cempaka putih, Kelurahan Sungai Ulin di Kota Banjarbaru. Hasil analisis dengan metode Analytical Hierarchy Process (AHP) menunjukkan bahwa faktor prioritas pada bank sampah terbaik adalah partisipasi masyarakat (59%), sub faktor prioritas partisipasi masyarakat yaitu kepedulian terhadap lingkungan (29%) dan sub faktor organisasi prioritas adalah manajemen tata kelola bank sampah (32%).