bluuebunny/crossref_metadata_2025 huggingface dataset:
Cardiotoxicity in chemotherapeutic agents
Authors: Modesto dos Santos Vitorino , Modesto dos Santos Lister Arruda
Published: April 2021

This Letter to the Editor aims to comment on the review by Duplyakov DV et al. published in this Journal, didactically discussing the cardiotoxicity in chemotherapy under the pathophysiological points of view as well as daily practical aspects. The growth of the oldest age groups of patients and the increased number of malignant entities undergoing chemotherapy enhances the significance of the cited work. One of the key points is the emphasis on the possibility of a known risk of cardiovascular damage due to chemotherapy surpass that of the malignancy under treatment. An additional short comment is about reversible cardiotoxicity in a 54-year-old Brazilian woman with breast cancer treated by trastuzumab. The herein commented articles can contribute to better understanding of mechanisms in cardiotoxicity related to chemotherapy, and to reduce the under diagnosis.
Association of signal transducer and activator of transcription 4 gene (restriction site7582694) single nucleotide polymorphism with systemic lupus erythematosus
Authors: Hamid Hamdan , Afzal Nadeem , Kashif Muhammad , Bashir Muhammad Adil , Jahan Shah
Published: April 2021

Background — Systemic lupus erythematosus (SLE) is an inflammatory autoimmune disease characterized by production of autoantibodies and deposition within various organs. The incidence of SLE averages 5 cases per 100,000 population. Various genome wide studies have shown association of STAT4 (signal transducer and activator of transcription 4) gene with SLE and lupus nephritis (LN). Therefore, this study was designed to determine single nucleotide polymorphism (SNP) in STAT4 (rs7582694) in local SLE, LN patients and healthy controls. Objective — To determine the frequency of STAT4 (rs7582694) gene polymorphism in systemic lupus erythematosus, lupus nephritis patients and healthy controls. Methods — It was a case-control study. Eighty samples were recruited for each of two study groups. Deoxyribonucleic acid (DNA) extraction was carried out using standard phenol chloroform method. Further, samples were processed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) conventional technique and genotypes were determined. Polymorphism analysis and allele frequencies were compared between groups using the chi-square test. Project was approved by the Ethical Review Board at the University of Health Sciences, Lahore, Pakistan. Results — Females were more inclined towards developing SLE. The study unveiled that SNP in STAT 4 gene (rs7582694) was associated with SLE patients in Pakistani population which indicates that this may play a role in susceptibility to SLE. Moreover, we infer that genetic variations within STAT4 (rs7582694) predispose patients to lupus nephritis. It was also evident that GG and GC genotypes were more susceptible of further transforming into SLE and LN. Conclusion: The findings of this study may contribute to a better understanding of underlying etiological and prognostic factors regarding SLE and LN.
Block-modular constructor as a tool of the learning community of teachers for designing educational events
Authors:   Moscow City University, Ioffe Andrey Naumovich , Bychkova Liudmila Vasil’evna ,   Moscow City University, Markova Valeriya Kirillovna ,   Moscow City University
Published: April 2021

The purpose of the article is to substantiate a block-modular constructor as a tool to overcome the costs of the traditional approach to design lessons. It is noted that it is applicable not only in the individual work of a teacher, but also in the activities of learning communities of teachers. The authors explain that an educational event as opposed to a traditional formal event can become personally significant and saturate educational activity with new discoveries, meanings and values. It can actualize the subjectivity of its participants. This is made possible by the selection of original and relevant content, which launches the engines for the appropriation of new knowledge – interest and surprise. The design and organization of the educational event, the revision of the ways of exchanging information and communicating with participants are also important. The article describes an approximate algorithm for working with a block-modular constructor, and also offers a navigator for designing an educational event, which allows teachers to work out its organizational, content and motivational components. A plan is presented that teachers can rely on in the joint development of an educational event, techniques of reflection and feedback are given to help the mentor of the learning community of teachers. In general, the idea of our article is to interest learning communities of teachers and their mentors in the possibilities of turning traditional formal events into personally significant educational events and collaboratively design educational events using a block-modular constructor.
Formation of the image of a preschool educational institution in the conditions of innovative activities
Authors:   Novosibirsk State Pedagogical University, Istyufeeva Zhanna Nikolaevna , Matveeva Valentina Gennadevna ,   Kindergarten No. 81" Preschool Academy "
Published: April 2021

The purpose of this article is to describe the practice of imaging as an innovative way of managing the development of an organization in the context of modern requirements for innovative activities of a preschool educational organization. The reasons are described and effective tools for constructing a positive image of an educational organization are highlighted. The experience of imaging a preschool educational institution is presented through the characteristics of the image components (image of the service, level of psychological comfort, media image, visual image of the organization, individual image of the head, image of staff), which showed its effectiveness and determined further management strategy.
The possibilities of theatrical art in the devel-opment of the negotiation competence of the teacher-mediator
Authors:   Siberian Federal University, Byvshenko Anastasia Sergeevna , Vlasova Natalia Vladimirovna ,   Siberian Federal University, Ivanov Nikita Andreevich ,   Siberian Federal University, Kuzmin Dmitry Nikolaevich ,   Siberian Federal University
Published: April 2021

The purpose of the article is the theoretical substantiation of the didactic potential of the means of theatrical art in the development of the negotiation competence of the future teacher-mediator. The main idea of the research is to consider the problem of organizing the training of negotiators for the field of education at the interdisciplinary level, which ensures the complex nature of the educational activities of students-future teachers-mediators. More results consist in the presentation of an innovative approach to the development of the negotiation competence of the teacher-mediator, in particular, in development of the idea to Supplement the structure of the negotiation competence of acting component, the formulation of the scientific definition of acting competence of the teacher-mediator, development and justification of the conditions of realization of educational activity in the University by means of theatrical art, contributing to the successful professionalization of the future teacher-mediator. The theoretical significance of the research is to expand the understanding of the phenomenon of negotiation competence in relation to acting creativity, in particular, with acting technique, and to identify opportunities for developing the negotiation competence of a future teacher-mediator based on the methodology of theatrical art (on the example of theatricalization, forum theater and the use of acting and directing memoirs in professional training).
Psychological enlightenment of subjects of the inclusive educational process
Authors:   Novosibirsk State Pedagogical University, Ryapisova Alevtina Gennadievna , Yakushenko Svetlana Olegovna ,   Novosibirsk State Pedagogical University
Published: April 2021

The article presents the main results of research activities devoted to the implementation of the labor function of a teacher-psychologist – psychological enlightenment in an inclusive practice. The key concept is defined: psychological enlightenment is understood as a type of professional activity of a teacher-psychologist, which provides for the dissemination of scientific psychological knowledge, contributes to the expansion of horizons and the development of the value attitude of individuals and groups of people to the phenomena in the educational space. The purpose of the study is to characterize the actual aspects of the content and adequate forms and methods of psychological enlightenment in the context of inclusive practice. Thematic content, various forms and methods of psychological enlightenment of subjects of inclusive education – teachers, parents and students of different ages-are proposed. As an author’s result, a project of the activity of a teacher-psychologist on the organization of psychological enlightenment on the basis of a calendar of events related to inclusive education was developed. On the basis of calendar and thematic planning, recommendations for organizing outreach activities in an educational organization that implements inclusive education are proposed.
Egalitarian and market land reforms in the context of basic human rights and public welfare
Authors:   State Institution ", Borodina Olena ,   Institute for Economics and Forecasting, NAS of Ukraine"
Published: April 2021

Based on the generalization and analysis of modern scientific and applied approaches and real results of land transformations in the last century in transition economies, the article reveals the essence of the nature of market and egalitarian land reforms, as well as their goals and general economic results. Egalitarian reform has as its main priority a rapid reduction of rural poverty and development of the new landowners’ skills to build their potential for its implementation in the general societal context. Market-oriented land reform aims at economic efficiency of the market based allocation of resources to ensure the growth of export-oriented agricultural production. Egalitarian land reform focuses on human and the realization of his or her basic rights, while market land reform focuses on the economy. Empirical data on land reforms in China show that their egalitarian nature was based on the creation of a society with equal opportunities of its members in the management of and access to land resources and material benefits obtained from them, and on ensuring a wide spread of the benefits from rural growth in society as a whole. Currently, China is the only country in the world that progressed from a "country of low human development" in 1990 to a "country of high human development" in 2018. The author proves that the purpose of land reform cannot be primitivized to a simple division of land into plots for transfer to private ownership based on free market turnover. Guaranteeing basic human rights and achieving public welfare from a land reform are achieved not only via obtaining land in private ownership, but also via supporting these acts with a fair distribution of control over the production process. Imposing on society a pseudo-scientific concept that land is a commodity that, like an apartment, mobile phone or bag of feed, can be freely bought and sold on market at open auctions, which will consolidate the country's economic power would inevitably lead to even greater income polarization, violation of basic human rights and, consequently, to social confrontations and significant social upheavals. The publication was prepared within research project on "Spatial justice in land use for sustainable development of rural areas" (State Registration No 0121U108142).
Helicobacter pylori in the clinic of internal medicine
Authors:   Kharkiv Medical Academy of Postgraduate Education, Zvyagintseva T.D. , Gamanenko Ya.K. ,   Kharkiv Medical Academy of Postgraduate Education
Published: April 2021

The article is devoted to the analysis of the literature on the problem of the possible relationship of Helicobacter pylori in the pathogenesis of various extragastric pathologies - diabetes mellitus, metabolic syndrome, cardiovascular diseases and multiple sclerosis. It is possible that Helicobacter pylori infection plays an independent role in the pathogenesis of these diseases.
Molecular mechanisms of insulin resistance in normal pregnancy and gestational diabetes
Authors:   Kharkiv National Medical University, Zhuravlyova L.V. , Sokolnikova N.V. ,   Kharkiv National Medical University, Rogachova T.A. ,   Kharkiv National Medical University
Published: April 2021

The purpose of this review article is to analyze current information on the molecular mechanisms of gestational diabetes and the prospects for their use in the further development of new effective treatments for this common pathology. Decreased ability of insulin to bind to its receptor, decreased IRS-1 expression and GLUT-4 translocation, and increased levels of p85α-PI-3 kinase subunits are involved in the development of insulin resistance during pregnancy. In gestational diabetes, there are not only more significant changes of the above mentioned indicators, but also increased levels of pro-inflammatory factors: TNF-α, IL-6, leptin and decreased insulin-sensitizing factors: adiponectin and PPAR-γ. Therapeutic measures aimed at normalizing the secretion of cytokines and adipokines reduce the risk of gestational diabetes mellitus and its complications and require further development
D. K. Zabolotny as the one out of the founders of the domestic microbiological school: activity of the scientist at the head of allukrainian academy of SCIENCES
Authors:   Kharkiv National Medical University, Demochko H.L. , Chernukha O.V. ,   Kharkiv National Medical University
Published: April 2021

The artiсle examines the activities of the outstanding domestic epidemiologist Danilo Zabolotny as president of the Ukrainian Academy of Sciences. During this time a new version of its charter was developed and adopted. Despite the illness, the head of the Academy of Sciences constantly carried out field visits, which helped to determine the list of the most pressing problems, the solution of which could be found in the walls of the UAS. A significant achievement of the scientist was the discovery the Institute of Microbiology and Virology on the base of UAS in the summer of 1928. Danylo Zabolotny personally supervised personnel policy, attracting young scientists to work at the academy, which contributed to the emergence of scientific schools. Thanks to his efforts, the material and technical base of the Ukrainian Academy of Sciences and its provision with scientific literature have been significantly improved. It is concluded that the significance of Danylo Zabolotny’s activity as the president of the Academy of Sciences is primarily in the large organizational work aimed at establishing a close connection between theory and practice, the correspondence of scientific knowledge to the requirements of time
Biological diagnosis of inflammatory bowel disease: current ideas and future achievements.
Authors:   Kharkiv Medical Academy of Postgraduate Education, Zvyagintseva T.D. , Yaroshenko A.V. ,   Kharkiv Medical Academy of Postgraduate Education
Published: April 2021

Article presents review of new biological methods for the diagnosis of IBD. The problem of late diagnosis of IBD remains relevant because of increased frequency of adverse consequences of the disease by increasing the length of the period when patients do not receive adequate treatment. Well-known today are biological markers of inflammatory bowel disease, which are determined by non-invasive methods and are often an alternative to colonoscopy. C-reactive protein (CRP) is recognized as one of the most important proteins in the acute inflammation phase. Changes in the content of fecal calprotectin (FCP) in patients with IBD due to the clinical activity of inflammatory bowel disease and are closely related to the extent of colon damage. New fecal biomarkers such as Defensin, Myeloperoxidase, Pyruvate kinase, Lipocalin and others are a sensitive tool for screening for inflammation of the intestine and an indicator of its severity. New fecal markers may help improve the diagnosis, evaluation, and clinical outcomes of treatment of patients with inflammatory bowel disease.
Técnica de “slalom” quirúrgico en estenosis de canal lumbar multinivel. Serie de casos tratados de manera simultánea con descompresión endoscópica y tubular con asistencia microscópica bilateral
Authors: Coombes Nicolás , Galaretto Eduardo , Guyot Juan Pablo , Fernández Norberto , Fuster Cristian
Published: April 2021

Introducción: La laminectomía unilateral para descompresión bilateral por abordaje único ha tomado relevancia en pacientes con estenosis multinivel, cuando se realiza en más de un nivel por un abordaje único, de manera alterna y de forma cruzada, al abordaje anterior es conocida como técnica de “slalom”. El objetivo de este artículo es presentar una serie de casos tratados con la técnica de “slalom” con asistencia endoscópica y microscópica bilateral, simultánea, en pacientes con estenosis de canal lumbar multinivel.

Materiales y Métodos: Análisis retrospectivo de pacientes tratados de forma simultánea, entre enero de 2017 y enero de 2018, todos operados por el mismo equipo quirúrgico con separadores tubulares, y asistencia endoscópica y microscópica simultánea.

Resultados: Se incluyó a 4 hombres, con una edad promedio de 73.5 años y patología lumbar multinivel. Se descomprimieron 10 segmentos (2,5 media de niveles por pacientes), con un tiempo quirúrgico promedio de 107 minutos. No hubo complicaciones asociadas y los pacientes recibieron el alta hospitalaria el día de la cirugía.

Conclusiones: La técnica de “slalom” mínimamente invasiva resulta ser un procedimiento muy eficaz para resolver síntomas de estenosis multinivel asociada a una técnica combinada bilateral con dos equipos quirúrgicos para el tratamiento de este tipo de pacientes.

Nivel de Evidencia: IV
Paciente con síndrome de Klippel-Trenaunay. Reporte de un caso de reemplazo articular de cadera suspendido durante la cirugía
Authors: Lopreite Fernando Adrián , Rodríguez Joaquín , Tillet Fernando , Gaggiotti Stefano , Cullari Leonardo Matías , Del Sel Hernán
Published: April 2021

El síndrome de Klippel-Trenaunay es un trastorno congénito infrecuente. Por lo general, afecta uno de los miembros inferiores. Los hallazgos típicos son angiomas, malformaciones venosas, várices hipertróficas con comunicaciones arteriovenosas e hipertrofia del miembro afectado que, en algunos casos, altera la estructura ósea. El objetivo de esta presentación es describir el caso de un paciente de 54 años en el que se programó un reemplazo articular de la cadera izquierda durante un año y la cirugía debió suspender por el riesgo de exanguinación, y analizar la bibliografía al respecto.
Vástagos estriados cónicos modulares en revisión de artroplastia total de cadera. Estudio multicéntrico. Resultados y complicaciones a mediano plazo
Authors: Iglesias Santiago Luis , Vanoli Fernando , Pérez Alamino Leonel , Pioli Ignacio , Gómez José , Lopreite Fernando Adrián , Maletti Pablo , Del Sel Hernán , Allende Bartolomé L.
Published: April 2021

Introducción: Debido al crecimiento exponencial del número de artroplastias de cadera, se espera una mayor cantidad de revisiones en las próximas décadas. Los vástagos cónicos estriados modulares se han vuelto populares en la última década por sus resultados favorables. El objetivo de este estudio es evaluar los resultados, las complicaciones y la tasa de supervivencia de estos vástagos en las revisiones de cadera, con un seguimiento a mediano plazo.

Materiales y Métodos: Estudio multicéntrico, retrospectivo. Se incluyeron 182 pacientes a quienes se les realizó una cirugía de revisión de cadera entre 2007 y 2017. Se colocaron 185 vástagos cónicos estriados de fijación distal. El déficit de stock óseo femoral se clasificó según Paprosky y Burnett; y las facturas periprotésicas, según la clasificación de Vancouver. Se evaluó a los pacientes clínicamente con el Harris Hip Score (HHS) y con radiografías a los 3 meses y anualmente para evaluar la estabilidad del vástago, la subsidencia y el aflojamiento, así como la consolidación de la osteotomía.

Resultados: Seguimiento medio 55.18 meses. El HHS posoperatorio tuvo una media de 80,28 (DE = 12,8, IC95% 78,5-82,97). No hubo complicaciones posoperatorias en el 75,4% de los pacientes. Las complicacionesmás frecuentes fueron inestabilidad (7,6%) y subsidencia del implante (11,5%). Al final del seguimiento, el 95,05% de los pacientes tenía un implante estable.

Conclusiones: Los vástagos cónicos estriados modulares de fijación distal proporcionan una solución confiable, reproducible y duradera para el manejo de revisiones de componentes femorales a medio plazo.

Nivel de Evidencia: IV
Osteomielitis de pubis. Reporte de caso
Authors: Solernó Sebastián , Cattáneo Andrés , Ifran Macarena , Romano Osvaldo
Published: April 2021

La osteomielitis de pubis es una enfermedad infrecuente (<2% de todas las infecciones óseas) que rara vez se sospecha y su diagnóstico suele pasarse por alto, se la confunde fácilmente con pubalgias que no responden al tratamiento. Consideramos que la comunicación de este caso puede serle útil al traumatólogo para no olvidar este cuadro extremadamente infrecuente y disminuir el costo del diagnóstico y el tratamiento.
Caesaropapism and Secularism in the Byzantine and Russian Tradition
Authors: Eldin Michael A. , Malozemov Sergey I.
Published: April 2021

Introduction. The role of Orthodox confessional heritage and the analysis of social traditions of the Balkan and Russian peoples are considered in the generalizing characteristic of the spiritual creations of the thinkers of Rus and Russia. The multidirectional tendencies of anti-clerical forces on the one hand, and of the Church community on the other, indicate that the topic of secularization of Russian society has not received an actual resolution. The purpose of the article is to examine the understanding of the processes of caesaropapism and secularism in Russian society, as well as the historiosophical and methodological consequences of this understanding. Materials and Methods. An integrative approach combined with historical-methodological and philosophical-historical analysis is considered as a theoretical and methodological research strategy. The solution of research problems was provided by a complex of complementary theoretical (analysis of scientific, historical literature, journalistic research on the problem under study, comparative analysis of texts, comparison, generalization) and empirical (study and generalization of normative and legal documents of the concepts of caesaropapism and secularism) methods. Results. The considered model of understanding secularization and secularism in the realities of Russian history indicates the secondary, borrowed nature of these concepts. According to the authors, the Decrees of the Byzantine emperors, acts of the Council of people’s Commissars “On the separation of Church from state and Church from school” did not meet the expectations of the participants of the local Council of the Russian Orthodox Church, who expressed their aspirations in the document “on the legal status of the Russian Orthodox Church”. Discussion and Conclusion. The expected effect of the actual understanding of the processes can be a well-built model of state-Church relations, which can only appear if the diverse interests of the actors of modern state-religious policy in Russia are balanced. The proposed provisions and conclusions create prerequisites for further study of the phenomena of secularism and secularization in the design of the state-religious landscape of the near future.
Sects and Religious Movements in the Russian Empire in the Second Half of the XIX – First Quarter of the XX Century оn the Pages of the Simbirsk and Samara Diocesan News
Authors: Rukhlin Alexey N.
Published: April 2021

Introduction. The presented article touches upon one of the serious religious problems of Russian history, the phenomenon of “sects”. The author, with the help of the provincial periodical press of the Russian Orthodox Church, tried to highlight the activities of sectarians in the second half of the 19th century until the end of the First World War. The significance of the material presented is undoubtedly, especially in the context of the emergence of new radical sects. To these days, too much depends on the experience of solving this issue, which is acute in our country. The successful resolution of religious problems is the foundation of Russia’s peaceful existence. The purpose of the article is to determine the historical place of sects and sectarianism in the religious life of provinces Middle Volga region, based on the characteristics of their condition and activities, to highlight the policy of the Russian Orthodox Church in relation to sectarians in the period under review, to reveal the special role of the church periodicals aimed at forming environment of negative perception of sects, heretics and all those who broke away from the “true Orthodox teaching”. Materials and Methods. The most important in the study, based on the provisions formulated by the above authors, is the historical method, or, as it is also formulated, the principle of historicism. In carrying out this scientific research, the author relied, first of all, on special historical or general historical methods. Research Results. The study showed that the church media, controlled by local bishops and supported by the secular authorities, carried out an anti-sectarian policy on the pages of their magazines. The Russian Church in Russia had the status of a “state religion” and a monopoly on religious consciousness, therefore it suppressed any deviations from its dogmas. The anti-sectarian tone did not change until 1917. Discussion and Conclusion. We can conclude that the topic of sectarianism is still relevant, moreover, sects continue to arise and develop throughout the world. As long as there are official religions, new sects will be born and spun off. The image of a heretic-sectarian, when necessary, is actively used in propaganda in the media today. The proposed provisions and conclusions create prerequisites for further study of this problem.
Carpentry in the Economic Activities of the Mordovians
Authors: Svyatkin Mihail I.
Published: April 2021

Introduction. The article examines the role and importance of carpentry in the economic activity of the Mordovians. On the basis of pre-revolutionary statistical documents, reports of provincial and district zemstvo committees, the profitability of carpentry was studied. The main reasons for the development of fishing activities in the peasant environment and the places of permanent migrant workers among the Mordovians are identified. The author paid attention to the contribution of domestic and foreign researchers to the study of this topic. Materials and Methods. The research is based on the following methods: comparative-historical, historical-genetic, problem-chronological, structural-system. Of the general scientific research methods, logical, descriptive, narrative, generalization, classification and systematization were used. Traditional methods of ethnographic science were also used, such as polling and interviewing the population. To achieve the results of the study, archival sources, reports of county and provincial statistical committees, data from the All-Russian census of 1897, as well as field research materials collected by the author in Mordovian villages were used. Results. In the second half of the XIX – early XX century, in connection with the active development of commodity-money relations, handicraft industry and various types of otkhodniki, one of which was carpentry, acquired an important role in the economic activity of peasants. Carpentry not only provided the peasant economy financially, but also promoted interethnic dialogue and the enrichment of the traditional material and spiritual culture of the Mordovian people. Thus, the economic activity of the Mordovians is inextricably linked with its ethnic history. Industrialization and industrial development, the introduction of new technologies in the late 19th and early 20th centuries became important factors in increasing labor productivity and increasing the demand for labour. The construction of new industrial facilities and buildings required more people who owned carpentry. Many peasants, in order to find work, went to such large construction sites and sometimes remained to live in these places. Economic factors have become, in many ways, the reasons for the dispersed settlement of the Mordovians. In the pre-revolutionary period, a significant contribution to the study of traditional crafts and occupations was made by P. S. Pallas, I. I. Lepekhin, and others. Among Soviet and modern researchers, it is worth noting V. N. Kuklin, I. I. Firstov, A. S. Luzgin, N. F. Mokshin, G. A. Kornishina, E. N. Mokshina and others. Conclusion. Thus, carpentry was one of the lucrative occupations and was of great importance in the economic activities of the Mordovians.
Venetoclax alkalmazása myeloma multiplexben
Authors: Szita Virág Réka , Varga Gergely
Published: April 2021

Összefoglaló. Bár az elmúlt évtizedben számos új gyógyszer került be
a myeloma multiplex kezelésének eszköztárába, a betegség az esetek nagy részében
továbbra is gyógyíthatatlan, ezért új hatóanyagok bevonására van szükség. A
venetoclax a bcl-2 antiapoptotikus fehérje gátlása révén ható új típusú
gyógyszermolekula, amelynek különböző hematológiai malignitásokban történő
alkalmazásáról az elmúlt években számos tanulmány készült. Myeloma multiplexben
való alkalmazása a hatásmechanizmusnak megfelelően a magas bcl-2/mcl-1, illetve
bcl-2/bcl-xl aránnyal rendelkező betegeknél előnyös, amely kedvező konstelláció
elsősorban a t(11;14) transzlokált betegeknél áll fenn. Bár korai tanulmányok
mutattak kedvező eredményeket más citogenetikai eltéréssel rendelkező betegeknél
is, a törzskönyvezési igénnyel indított nagy, randomizált 3. fázisú Bellini
klinikai vizsgálat a venetoclaxszal kezelt betegeknél ugyan a t(11;14)
csoportban nagyon kedvező eredményekre vezetett, de a nem t(11;14) betegeknél
többlethalálozást és OS-csökkenést mutatott ki. A vizsgálati eredmények
értelmében a venetoclax-alapú terápia myeloma multiplexben csak t(11;14)
betegeknek ajánlható. Az optimális alkalmazással és kombinációs partnerekkel
kapcsolatban további vizsgálatok szükségesek, mindazonáltal a venetoclax terápia
a myeloma multiplex személyre szabott kezelésének irányába tett első lépést
jelentheti.

Summary. Although recent decades introduced several new drugs to
multiple myeloma therapy, the disease is still considered incurable in most
cases and thus warrants the development of new agents. Venetoclax is a novel
type of drug inhibiting the antiapoptotic bcl-2 molecule whose use in varying
hematological malignancies has been evaluated by a multitude of studies in
recent years. Considering its mechanism of action, application in multiple
myeloma is possible in patients with high bcl-2/mcl-1 and bcl-2/bcl-xl ratios.
This favourable constellation is primarily found in patients with t(11;14)
translocations. Although early studies showed some promising results in patients
with different citogenetic makeup, the large randomized phase 3 Bellini study
which confirmed ventetoclax’s high effectivity in t(11;14) patients, proved
increased mortality and OS loss in the case of non-t(11;14) patients treated
with the drug. In light of these results, venetoclax based therapy may only be
recommended for t(11;14) myeloma patients. Further research is needed to
determine optimal application and combination partners, but venetoclax therapy
may be the first step towards personalized myeloma care.
Mély remisszióban lévő CML-es beteg hirtelen kezdetű pancytopeniája
Authors: Harasztdombi József , Lakatos Gergely , Szlávik János , Mikala Gábor
Published: April 2021

Összefoglaló. A mély molekuláris remisszióban lévő CML-es betegnél
láz, izomfájdalmak alakultak ki, melyet jelentős kétvonalas cytopenia kísért.
Alapbetegségének blasztos transzfomációja mellett, az utazási anamnézisre
tekintettel a differenciáldiagnosztika trópusi betegségekre is kiterjedt.
Dengue-lázat diagnosztizáltunk, melyből a beteg szövődmény nélkül felépült.

Summary. A CML patient in deep molecular remission was admitted with
fever, muscle pain, followed by pronounced bilineage cytopenia. In addition to
possible blastic transformation, tropical diseases were also included in the
differential diagnosis, due to travel history. Dengue fever was diagnosed, and
the patient recovered without any complications.
Confident Learning: Estimating Uncertainty in Dataset Labels
Authors: Northcutt Curtis , Jiang Lu , Chuang Isaac
Published: April 2021

Learning exists in the context of data, yet notions of confidence typically focus on model predictions, not label quality. Confident learning (CL) is an alternative approach which focuses instead on label quality by characterizing and identifying label errors in datasets, based on the principles of pruning noisy data, counting with probabilistic thresholds to estimate noise, and ranking examples to train with confidence. Whereas numerous studies have developed these principles independently, here, we combine them, building on the assumption of a class-conditional noise process to directly estimate the joint distribution between noisy (given) labels and uncorrupted (unknown) labels. This results in a generalized CL which is provably consistent and experimentally performant. We present sufficient conditions where CL exactly finds label errors, and show CL performance exceeding seven recent competitive approaches for learning with noisy labels on the CIFAR dataset. Uniquely, the CL framework is not coupled to a specific data modality or model (e.g., we use CL to find several label errors in the presumed error-free MNIST dataset and improve sentiment classification on text data in Amazon Reviews). We also employ CL on ImageNet to quantify ontological class overlap (e.g., estimating 645 missile images are mislabeled as their parent class projectile), and moderately increase model accuracy (e.g., for ResNet) by cleaning data prior to training. These results are replicable using the open-source cleanlab release.
Reliability basis for assessment of existing building structures with reference to sans 10160
Authors: Holický M , Retief J V , Viljoen C
Published: April 2021

The principles of structural reliability are firmly established to provide the basis for structural performance as incorporated in design standards. Reliability-based procedures provide for variabilities and uncertainties that could reasonably be expected during the design service life of the structure. However, not all possible conditions to which all structures are exposed during such an extended service period can be accounted for effectively and economically at the design stage. The assessment of the reliability performance of an existing structure therefore forms an integral part of structural management and engineering practice. Despite the lag between the development and implementation of a basis for design and assessment of structures, the extensive body of information on structural assessment progresses steadily towards standardisation. This paper provides a review of the progress to provide background information towards extending the scope of South African structural standards to include guidance on structural assessment. The focus is on such developments to include provisions for existing structures in Eurocode, together with related investigations. In addition to a general review of background investigations, interrelationships between the basis of design and assessment for Eurocode (potentially also for South Africa) are considered. The main elements of a standardised basis for assessment are defined, and alternative assessment approaches are presented and demonstrated by representative examples. In conclusion, an outline of a possible development path for implementation in South Africa is provided.
A Patient Activities of Daily Living Scale for Amyotrophic Lateral Sclerosis
Authors: Herbelin Laura , Statland Jeffrey , Kimminau Kim , Waitman Russ , Heim Andrew , Dwyer Sally , Johnsen Kelli , Barohn Richard
Published: April 2021

Background: Motor neuron disorders are rare, progressive neurodegenerative diseases which affect multiple domains of motor function. The ability to assess function from home using an electronic medical record (EMR) would facilitate pragmatic studies.

Objective: To develop a Patient Activity of Daily Living scale for Amyotrophic Lateral Sclerosis and other motor neuron disorders (PADL-ALS) to support large pragmatic trials.

Methods: The Greater Plains Collaborative Clinical Data Research Network (GPC) developed and tested the feasibility of using the PADL-ALS.  We convened patient and caregiver focus groups and in-person meetings to recommend changes to the ALS Functional Rating Scale-Revised (ALSFRS-R), which clarified language and added questions about pseudobulbar affect, pain, and faith.  Feasibility was determined by conducting a survey of participants identified using EMR-computable phenotypes and returned via patient-preferred modalities.

Results: Surveys were distributed to 1079 participants at nine GPC health systems.  The survey response rate was 44.4% (range 12.9-57.66%): male to female ratio 1.56; 84% self-identified as a patient with ALS.  Patient respondents used computers or tablets more frequently than caregivers responding on their behalf.  The PADL-ALS correlated to clinic-performed ALSFRS-R within 4 weeks of survey completion (n=33, rho=0.93, Kansas only).  The pseudobulbar affect question correlated to functional motor burden.  Over 80% agreed to be contacted for future research opportunities.

Conclusion:  We demonstrated the feasibility of determining functional burden with the PADL-ALS using an EMR-computable phenotype.  Future directions include implementing the PADL-ALS to answer pragmatic questions about ALS care.
Antibody lyophilization v1
Authors: Camacho Christine , MB Bosse Marc , Bendall Sean , Angelo Mike
Published: April 2021

This protocol details the lyophilization process of stock antibodies using an overnight lyophilization process.
Lyophilized metal-antibody reconstitution v1
Authors: MB Bosse Marc , Angelo Mike , Bendall Sean
Published: April 2021

This protocol describes the procedure to prepare the reconstitution buffer and the resuspension of metal-labeled antibody.
Guidance for populating GenomeTrakr metadata templates (BioSample and SRA) v4
Authors: Timme Ruth , Balkey Maria , Wolfgang William , Strain Errol
Published: April 2021

PURPOSE: Guidance on how to populate NCBI's metadata packages, maximizing interoporability for foodborne pathogen surveillance. SCOPE: This protocol provides detailed instructions for populating the following two templates: 1. BioSample metadata: guidelines to populate the custom One Health Enteric Package, which is a modification of NCBI's combined pathogen package. 2. SRA metadata: NCBI's generic sequence metadata template for SRA submissions.
HuBMAP - STANFORD RTI Multiplex Ion Beam Imaging (MIBI) MODALITY OVERVIEW v1
Authors: MB Bosse Marc , Filiz Ferda , Greenwald Noah , Camacho Christine , Kong Alex , Kagel Adam , Bendall Sean , Angelo Mike
Published: April 2021

We aim to provide high resolution, high dimensional images of human placenta in early pregnancy by using our multiplexed ion beam imaging methodology for building an atlas of human organs.
Social Inclusion and Exclusion for First Nations LGBTIQ+ People in Australia
Authors: Soldatic Karen , Sullivan Corrinne , Briskman Linda , Leha John , Trewlynn William , Spurway Kim
Published: April 2021

This thematic issue of Social Inclusion highlights the connections between First Nations LGBTIQ+ people’s intersecting identities and inclusionary and exclusionary process in settler-colonial Australia. In this editorial, we briefly introduce key concepts and summarise the different contributions in the issue, providing some general conclusions and guidance on a possible future research agenda.
Current trends in entrepreneurship motivation: interdisciplinary approach
Authors: Mazur I. , Gura V. , Solodovnikova K.
Published: April 2021

The essence of motivation of entrepreneurs is revealed through the types of personal intelligence and the proposed entrepreneurial motivation system. The motives of the entrepreneur and the consumer are investigated. The system of motivation of the businessman is offered. The importance of the creative function of entrepreneurship in the conditions of the fourth industrial revolution is substantiated. Customer-oriented as an important component in the motivation of modern entrepreneurship is considered, the customer-oriented approach and customer-oriented culture of the entrepreneur are analyzed. The need for digitalization in entrepreneurship is noted. An interdisciplinary approach has been applied in the study of modern trends in the motivation of entrepreneurs.
The authors propose to expand the narrowly specialized research methodology and introduce an integrated approach that allows to involve the methodology of individual areas of knowledge in the process of interdisciplinary research. It is revealed that the modern approach to studying the motivation of the entrepreneur does not allow the use of the prognostic function of science, as it is based on the fact that modern studies of business motivation do not take into account the peculiarities of gender differences.
Stakeholders’ perceptions about the first review of IFRS for SMEs standard
Authors: Marina A.-G.
Published: April 2021

Given the importance of small and medium enterprises at the national level by their essential role in the economy and the time passed since the issuance of the IFRS for SMEs standard it is still unclear what is the amount of financial information that users of SMEs need and which are the most useful informations for them. The aim of this research is to conduct a qualitative analysis regarding the answers received on the comment letters submitted to the first Comprehensive Review of the IFRS for SMEs 2012 and to show the significant contributions made by respondents on future recommendations for the development and review of the standard. The purpose is to study respondents’ comments received on the Request for Information and the extent to which these comments are valuable to future agenda of the standard. At the same time, the content analysis shows us what is the interest of the respondents regarding the modification of the standard in order to best fit the national context.
Impacto del programa autorregulación para mejorar la redacción de textos académicos en estudiantes de Educación Superior
Authors: Guzmán Iparraguirre Eddy Margarita
Published: April 2021

Este artículo reporta los resultados más relevantes del impacto del Programa Autorregulación para mejorar la redacción de textos académicos en estudiantes de educación superior. Este estudio se basó en el Aprendizaje autorregulado de Pintrich, y en la teoría de Flower y Hayes. Se desarrolló de manera experimental con corte transversal en una población de 90 estudiantes. Para el recojo de datos se diseñó una rúbrica que fue sometida a pruebas de validez y confiabilidad, según las exigencias de la rigurosidad científica. Se concluye que la autorregulación mejora significativamente la redacción de textos académicos de los estudiantes al presentar un nivel aceptable con un 71% después de la aplicación del programa.
"No Silver Bullet Solution": Cruel Optimism and Canada’s COVID-19 Public Health Messages
Authors: Holmes Christina , Krautwurst Udo , Graham Kate , Fernandez Victoria
Published: April 2021

Science twines through many of the discussions related to hope for a return to normalcy within public discussions of COVID‑19. The framings of techno-scientific solutions for COVID‑19 are similar to those that are presented to address many societal problems. The messy scientific and regulatory underpinnings of this desired silver bullet rarely make it fully into view. Technoscientific-related hope and its associated affects can operate as a kind of “cruel optimism” (Berlant 2010, 2011). It can be an affective response to return to life as “normal” that is psychologically soothing, even as its enactment may replicate destructive social, political, and economic structures. Hope and technoscience thread throughout the interactions between journalists and health officials in the health press briefings in the first wave of the COVID‑19 pandemic. Technoscientific complexity that challenges the desire to return to normal is rarely brought up in Ontario and Nova Scotia public health briefings. But when it is, health officials in this zone of interaction balance explanations of scientific reality and caution, while attempting to not crush hope for a techno-scientifically mediated return to normal. As such, public health discourse obscures or tempers cruel optimism rather than directly confronting it.
Circling COVID: Making in the Time of a Pandemic
Authors: Wenzel Abra
Published: April 2021

The following is an account of some current Indigenous artistic trends and responses during the COVID‑19 pandemic. The pandemic has resulted in Indigenous artists adapting social media to maintain COVIDdisrupted knowledge networks about traditional making. In so doing, they have reimagined how to continue links within and beyond their own cultural communities. Art has become both an outlet and a connection to neighbours, friends, and strangers across geographic boundaries. Indigenous textile artists are refashioning their art and materials to maintain and reflect contemporary Indigenous issues and values that emphasize their community and reflect survivance, all while safely at a distance. The artists highlighted and discussed in this article include Dene, Métis, and Inuvialuit women with whom I have worked and who have contributed to my research in the Northwest Territories (NWT), as well as other Indigenous artists from across North America well known for their creative work. Because the coronavirus has all but eliminated non-essential travel to the NWT, the information that is presented has been developed through online exchanges with these women and by observing the artists’ public social media accounts over the course of six months.