bluuebunny/crossref_metadata_2025 huggingface dataset:
Novel Hopf Bifurcation Exploration and Control Strategies in the Fractional-Order FitzHugh–Nagumo Neural Model Incorporating Delay
Authors: Zhang Yunzhang , Xu Changjin
Published: April 2024

In this article, we propose a new fractional-order delay-coupled FitzHugh–Nagumo neural model. Taking advantage of delay as a bifurcation parameter, we explore the stability and bifurcation of the formulated fractional-order delay-coupled FitzHugh–Nagumo neural model. A delay-independent stability and bifurcation conditions for the fractional-order delay-coupled FitzHugh–Nagumo neural model is acquired. By designing a proper PDp controller, we can efficaciously control the stability domain and the time of emergence of the bifurcation phenomenon of the considered fractional delay-coupled FitzHugh–Nagumo neural model. By exploiting a reasonable hybrid controller, we can successfully adjust the stability domain and the bifurcation onset time of the involved fractional delay-coupled FitzHugh–Nagumo neural model. This study shows that when the delay crosses a critical value, a Hopf bifurcation will arise. When we adjust the control parameter, we can find other critical values to enlarge or narrow the stability domain of the fractional-order delay-coupled FitzHugh–Nagumo neural model. In order to check the correctness of the acquired outcomes of this article, we present some simulation outcomes via Matlab 7.0 software. The obtained theoretical fruits in this article have momentous theoretical significance in running and constructing networks.
Time Dependence of Gel Formation in Lyotropic Nematic Liquid Crystals: From Hours to Weeks
Authors: Dombrowski Max , Herbst Michael , Preisig Natalie , Giesselmann Frank , Stubenrauch Cosima
Published: April 2024

The combination of lyotropic liquid crystals (LLCs) and low-molecular-weight gelators (LMWGs) for the formation of lyotropic liquid crystal gels (LLC gels) leads to a versatile and complex material combining properties of both parent systems. We gelled the calamitic nematic NC phases of a binary and ternary system using the LMWG 3,5-bis-(5-hexylcarbamoyl-pentoxy)-benzoic acid hexyl ester (BHPB-6). This binary system consists of the surfactant N,N-dimethyl-N-ethyl-1-hexadecylammonium bromide (CDEAB) and water, whereas the ternary system consists of the surfactant N,N,N-trimethyl-N-tetradecylammonium bromide (C14TAB), the cosurfactant n-decanol, and water. Though containing similar surfactants, the gelled NC phases of the binary and ternary systems show differences in their visual and gel properties. The gelled NC phase of the binary system remains clear for several days after preparation, whereas the gelled NC phase of the ternary system turns turbid within 24 h. We investigated the time evolution of the gel strength with oscillation rheology measurements (a) within the first 24 h and (b) up to two weeks after gel formation. The shape of the fibers was investigated over different time scales with freeze fracture electron microscopy (FFEM). We demonstrate that despite their similarities, the two LLC gels also have distinct differences.
Assessment and Management of Atrial Fibrillation in Older Adults with Frailty
Authors: Rosas Diaz Andrea Nathalie , Troy Aaron L. , Kaplinskiy Vladimir , Pritchard Abiah , Vani Rati , Ko Darae , Orkaby Ariela R.
Published: April 2024

Atrial fibrillation (AF) is a major driver of morbidity and mortality among older adults with frailty. Moreover, frailty is highly prevalent in older adults with AF. Understanding and addressing the needs of frail older adults with AF is imperative to guide clinicians caring for older adults. In this review, we summarize current evidence to support the assessment and management of older adults with AF and frailty, incorporating numerous recent landmark trials and studies in the context of the 2023 US AF guideline.
Metabolically Tailored Selection of Ornamental Rose Cultivars through Polyamine Profiling, Osmolyte Quantification and Evaluation of Antioxidant Activities
Authors: Kebert Marko , Rašeta Milena , Kostić Saša , Vuksanović Vanja , Božanić Tanjga Biljana , Ilić Olivera , Orlović Saša
Published: April 2024

Roses (genus Rosa), renowned for their economic significance and aesthetic appeal, face multifaceted challenges in cultivation due to biotic and abiotic stressors. To address these challenges, this study explores the role of osmolytes, particularly polyamines, proline and glycine betaine, as well as antioxidant capacities and condensed tannins, in enhancing stress tolerance in roses. Despite the genetic diversity inherent in roses, the metabolic aspect of stress tolerance has been underexplored in breeding programs. This paper investigates the intraspecific variability among 22 rose cultivars, focusing on osmolyte content (proline and glycine betaine), individual polyamines (putrescine, spermine and spermidine), as well as antioxidant activities, measuring radical scavenging capacity against 2,2′-azinobis(3-ethylbenzothiozoline-6-sulfonic acid (ABTS•+) and NO• radicals. Employing a targeted metabolomic approach, we quantified the levels of individual polyamines in both the petals and leaves of rose cultivars. This was achieved through high-performance liquid chromatography coupled with fluorescent detection following a derivatization pretreatment process. Within the evaluated cultivars, “Unique Aroma”, “Andre Rieu”, “Aroma 3”, “Frayla Marija” and “Trendy Fashion” stood out for their significantly elevated levels of total foliar polyamines. The predominant polyamine detected at both petal and leaf levels was putrescine, with concentrations ranging from 335.81 (“Zora Frayla”) to 2063.81 nmol g−1 DW (“Unique Aroma”) at the leaf level. Following putrescine, foliar spermidine levels varied from 245.08 (“Olivera Frayla”) to 1527.16 nmol g−1 DW (“Andre Rieu”). Regarding antioxidant capacity, the leaf extracts of rose cultivars “Zora Frayla” and “Natalija Frayla” were prominent by showing 68.08 and 59.24 mmol Trolox equivalents (TE) g−1 DW, respectively. The results highlight the intricate biochemical variability across rose cultivars and show that osmolytes, such as glycine betaine, proline and polyamines, and other biochemical markers can be used as reliable criteria for the selection of rose cultivars that are more resilient to biotic stress factors, especially powdery and downy mildew. Bridging fundamental research with practical applications, this study aims to contribute to the development of stress-tolerant rose cultivars adaptable to dynamic environmental conditions.
Insights into the Impact of Organizational Factors and Burnout on the Employees of a For-Profit Psychiatric Hospital during the Third Wave of the COVID-19 Pandemic
Authors: Seyffert Michael , Wu Chunyi , Özkan-Seely Gülru F.
Published: April 2024

In this paper, we provide insights into the interplay among the organizational, job, and attitudinal factors and employees’ intentions to resign during the third wave of the COVID-19 pandemic at a mental health hospital. We point out shortcomings in the relationship dynamics between executive administration and operational staff and propose a pathway to develop more effective leadership frameworks to increase job satisfaction. We integrate qualitative data from case information and open-ended questions posed to employees at a mental health hospital and quantitative data from a small-scale survey (n = 19). We highlight that the ability to achieve objectives, work autonomy, burnout, affective commitment, distributive and procedural justice, and job satisfaction are critical in determining individuals’ intentions to resign. Individuals identified disconnectedness and moral distress as critical aspects, while highlighting empathy, compassion, satisfaction, and confidence as pivotal elements. Mental healthcare settings could benefit from enhancing the staff’s ability to achieve objectives, work autonomy, affective commitment, and both distributive and procedural justice. Addressing burnout and implementing measures to increase job satisfaction are equally vital. Efficiently restructuring dynamics between various leadership levels and staff can significantly improve employee retention.
Molecular Biomarkers of Neurodegenerative Disorders: A Practical Guide to Their Appropriate Use and Interpretation in Clinical Practice
Authors: Agnello Luisa , Gambino Caterina Maria , Ciaccio Anna Maria , Masucci Anna , Vassallo Roberta , Tamburello Martina , Scazzone Concetta , Lo Sasso Bruna , Ciaccio Marcello
Published: April 2024

Neurodegenerative disorders (NDs) represent a group of different diseases characterized by the progressive degeneration and death of the nervous system’s cells. The diagnosis is challenging, especially in the early stages, due to no specific clinical signs and symptoms. In this context, laboratory medicine could support clinicians in detecting and differentiating NDs. Indeed, biomarkers could indicate the pathological mechanisms underpinning NDs. The ideal biofluid for detecting the biomarkers of NDs is cerebrospinal fluid (CSF), which has limitations, hampering its widespread use in clinical practice. However, intensive efforts are underway to introduce high-sensitivity analytical methods to detect ND biomarkers in alternative nonivasive biofluid, such as blood or saliva. This study presents an overview of the ND molecular biomarkers currently used in clinical practice. For some diseases, such as Alzheimer’s disease or multiple sclerosis, biomarkers are well established and recommended by guidelines. However, for most NDs, intensive research is ongoing to identify reliable and specific biomarkers, and no consensus has yet been achieved.
Treatment of Odontogenic Maxillary Sinusitis with the Use of Growth Factors in Advanced Platelet-Rich Fibrin for Immediate Closure of Oro-Antral Communication: A Case Report
Authors: Adamska Paulina , Pylińska-Dąbrowska Dorota , Stasiak Marcin , Kaczoruk-Wieremczuk Magdalena , Kozłowska Ewa , Zedler Adam , Studniarek Michał
Published: April 2024

Chronic odontogenic maxillary sinusitis (COMS), a prolonged inflammation of the maxillary sinus lasting over 12 weeks, is often a result of periapical lesions, marginal periodontitis, and complications like oro-antral communication (OAC) and fistula (OAF). OAC, commonly emerging post-teeth extraction in the lateral maxilla, lacks documented treatments using advanced platelet-rich fibrin (A-PRF). This study evaluates A-PRF’s efficacy in treating COMS and immediately sealing extensive OAC. A case of a 28-year-old male with COMS linked to a periapical lesion and supernumerary molars is presented. Treatment involved extracting specific teeth while preserving adjacent ones and using A-PRF for immediate OAC closure. A-PRF, enriched with growth factors, was pivotal in healing, showcasing enhanced tissue regeneration, pain reduction, and faster recovery. The findings suggest A-PRF as an effective adjunct in treating extensive OAC and COMS, proposing its inclusion in standard treatment protocols. This study underscores A-PRF’s potential in improving outcomes for patients with COMS and related complications.
The Inhibition Activity of Natural Methoxyflavonoid from Inula britannica on Soluble Epoxide Hydrolase and NO Production in RAW264.7 Cells
Authors: Kim Jang Hoon , Han Kyung-Sook , Lee Eun-Song , Kim Yong-Goo , Kim Yong-Il , Cho Byoung Ok , Lee Ik Soo
Published: April 2024

Soluble epoxide hydrolase (sEH) is an enzyme targeted for the treatment of inflammation and cardiovascular diseases. Activated inflammatory cells produce nitric oxide (NO), which induces oxidative stress and exacerbates inflammation. We identify an inhibitor able to suppress sEH and thus NO production. Five flavonoids 1–5 isolated from Inula britannica flowers were evaluated for their abilities to inhibit sEH with IC50 values of 12.1 ± 0.1 to 62.8 ± 1.8 µM and for their effects on enzyme kinetics. A simulation study using computational chemistry was conducted as well. Furthermore, five inhibitors (1–5) were confirmed to suppress NO levels at 10 µM. The results showed that flavonoids 1–5 exhibited inhibitory activity in all tests, with compound 3 exhibiting the most significant efficacy. Thus, in the development of anti-inflammatory inhibitors, compound 3 is a promising natural candidate.
Transfer Hydrogenation of Vinyl Arenes and Aryl Acetylenes with Ammonia Borane Catalyzed by Schiff Base Cobalt(II) Complexes
Authors: Skrodzki Maciej , Zaranek Maciej , Consiglio Giuseppe , Pawluć Piotr
Published: April 2024

A series of bench-stable Co(II) complexes containing hydrazone Schiff base ligands were evaluated in terms of their activity and selectivity in carbon-carbon multiple bond transfer hydrogenation. These cobalt complexes, especially a Co(II) precatalyst bearing pyridine-2-yl-N(Me)N=C-(1-methyl)imidazole-2-yl ligand, activated by LiHBEt3, were successfully used in the transfer hydrogenation of substituted styrenes and phenylacetylenes with ammonia borane as a hydrogen source. Key advantages of the reported catalytic system include mild reaction conditions, high selectivity and tolerance to functional groups of substrates.
Assessing the Benefits and Harms Associated with Early Diagnosis from the Perspective of Parents with Multiple Children Diagnosed with Duchenne Muscular Dystrophy
Authors: Bhattacharyya Oindrila , Campoamor Nicola B. , Armstrong Niki , Freed Megan , Schrader Rachel , Crossnohere Norah L. , Bridges John F. P.
Published: April 2024

Duchenne muscular dystrophy (DMD) is a rare neuromuscular disorder diagnosed in childhood. Limited newborn screening in the US often delays diagnosis. With multiple FDA-approved therapies, early diagnosis is crucial for timely treatment but may entail other benefits and harms. Using a community-based survey, we explored how parents of siblings with DMD perceived early diagnosis of one child due to a prior child’s diagnosis. We assessed parents’ viewpoints across domains including diagnostic journey, treatment initiatives, service access, preparedness, parenting, emotional impact, and caregiving experience. We analyzed closed-ended responses on a −1.0 to +1.0 scale to measure the degree of harm or benefit parents perceived and analyzed open-ended responses thematically. A total of 45 parents completed the survey, with an average age of 43.5 years and 20.0% identifying as non-white. Younger siblings were diagnosed 2 years earlier on average (p < 0.001). Overall, parents viewed early diagnosis positively (mean: 0.39), particularly regarding school preparedness (+0.79), support services (+0.78), treatment evaluation (+0.68), and avoiding diagnostic odyssey (+0.67). Increased worry was a common downside (−0.40). Open-ended responses highlighted improved outlook and health management alongside heightened emotional distress and treatment burdens. These findings address gaps in the evidence by documenting the effectiveness of early screening and diagnosis of DMD using sibling data.
A Machine Learning as a Service (MLaaS) Approach to Improve Marketing Success
Authors: Pereira Ivo , Madureira Ana , Bettencourt Nuno , Coelho Duarte , Rebelo Miguel Ângelo , Araújo Carolina , de Oliveira Daniel Alves
Published: April 2024

The exponential growth of data in the digital age has led to a significant demand for innovative approaches to assess data in a manner that is both effective and efficient. Machine Learning as a Service (MLaaS) is a category of services that offers considerable potential for organisations to extract valuable insights from their data while reducing the requirement for heavy technical expertise. This article explores the use of MLaaS within the realm of marketing applications. In this study, we provide a comprehensive analysis of MLaaS implementations and their benefits within the domain of marketing. Furthermore, we present a platform that possesses the capability to be customised and expanded to address marketing’s unique requirements. Three modules are introduced: Churn Prediction, One-2-One Product Recommendation, and Send Frequency Prediction. When applied to marketing, the proposed MLaaS system exhibits considerable promise for use in applications such as automated detection of client churn prior to its occurrence, individualised product recommendations, and send time optimisation. Our study revealed that AI-driven campaigns can improve both the Open Rate and Click Rate. This approach has the potential to enhance customer engagement and retention for businesses while enabling well-informed decisions by leveraging insights derived from consumer data. This work contributes to the existing body of research on MLaaS in marketing and offers practical insights for businesses seeking to utilise this approach to enhance their competitive edge in the contemporary data-oriented marketplace.
The Effects of Acute Deep Seawater Supplementation on Muscle Function after Triathlon
Authors: Aragón-Vela Jerónimo , González-Acevedo Olivia , De la Cruz-Márquez Juan Carlos , Rojas Ruíz Francisco Javier , Marín Manuel Martínez , Casuso Rafael A. , Plaza-Diaz Julio , Huertas Jesus F. Rodriguez
Published: April 2024

(1) Background: Trainers and athletes have always sought to reduce the failure of muscle function during long endurance events. However, nowadays, it is a topic that is generating much debate in the scientific field. Currently, deep-sea water (DSW) intake seems to be a suitable hydration alternative for this type of endurance event. Therefore, the aim of this study was to determine whether DSW consumption during a triathlon event could preserve muscle function after exercise. (2) Methods: Nineteen trained male triathletes (age = 39.0 ± 4.25 years; BMI = 23.67 ± 1.81 kg/m2) randomly performed three triathlons, one of them consuming DSW (Totum SPORT 30 AB, Laboratories Quinton International, S.L., Spain), the other consuming isotonic placebo and the last with tap water-hydration. A vertical jump test with countermovement and an isometric muscle strength test were conducted before and after the triathlon test. (3) Results: There was a significant difference between treatment × time during the isometric muscle strength test. Based on the Tukey post hoc analysis, the peak net force decreased statistically in the placebo (p = 0.045) and control conditions (p = 0.026), but not in the experimental condition (p = 0.121). In addition, all of the conditions studied obtained similar results in the countermovement vertical jump after exercise. (4) Conclusions: As a result, consumption of DSW seems to delay the failure of muscle function specifically in isometric exercises but does not improve performance in sports. Thus, DSW does not alter muscle capacity in a negative way; therefore, its consumption may be recommended.
The General Movement Optimality Score-Revised (GMOS-R) with Socioeconomically Stratified Percentile Ranks
Authors: Einspieler Christa , Bos Arend F. , Spittle Alicia J. , Bertoncelli Natascia , Burger Marlette , Peyton Colleen , Toldo Moreno , Utsch Fabiana , Zhang Dajie , Marschik Peter B.
Published: April 2024

Background: The general movement optimality score (GMOS) quantifies the details of general movements (GMs). We recently conducted psychometric analyses of the GMOS and developed a revised scoresheet. Consequently, the GMOS-Revised (GMOS-R) instrument necessitated validation using new percentile ranks. This study aimed to provide these percentile ranks for the GMOS-R and to investigate whether sex, preterm birth, or the infant’s country of birth and residence affected the GMOS-R distribution. Methods: We applied the GMOS-R to an international sample of 1983 infants (32% female, 44% male, and 24% not disclosed), assessed in the extremely and very preterm period (10%), moderate (12%) and late (22%) preterm periods, at term (25%), and post-term age (31%). Data were grouped according to the World Bank’s classification into lower- and upper-middle-income countries (LMICs and UMICs; 26%) or high-income countries (HICs; 74%), respectively. Results: We found that sex and preterm or term birth did not affect either GM classification or the GMOS-R, but the country of residence did. A lower median GMOS-R for infants with normal or poor-repertoire GMs from LMICs and UMICs compared with HICs suggests the use of specific percentile ranks for LMICs and UMICs vs. HICs. Conclusion: For clinical and scientific use, we provide a freely available GMOS-R scoring sheet, with percentile ranks reflecting socioeconomic stratification.
Pulmonary Vein Isolation with a Novel Size-Adjustable Cryo-Balloon Catheter: A Tailored Ablation Protocol
Authors: Teumer Yannick , Hilgarth Franziska , Katov Lyuboslav , Melnic Rima , Rottbauer Wolfgang , Bothner Carlo , Weinmann Karolina
Published: April 2024

Background: Pulmonary vein isolation (PVI) is a common therapeutic approach for symptomatic atrial fibrillation (AF). Among various techniques, cryo-balloon (CB) PVI is widely adopted, but, to date, established CB systems have had fixed balloon sizes. A novel size-adjustable CB, allowing balloon size adjustments during ablation, lacks sufficient data on optimal utilization in patient care. This study aims to systematically investigate this feature with a tailored ablation protocol. Methods: Our single-center prospective study included patients with paroxysmal or persistent atrial fibrillation undergoing first-time PVI with the size-adjustable CB from July 2023 to February 2024. Ablation was performed using the balloon size that provided better occlusion. The ablation protocol involved an initial occlusion test with the small balloon size (28 mm). If optimal occlusion (occlusion level 4) could not be achieved, an attempt with the larger balloon (31 mm) was initiated. Ablation was conducted using the balloon configuration that provided better occlusion of the pulmonary vein ostium. Results: Our prospective study includes 50 patients (median age [interquartile range, IQR]: 72 [65; 79] years, 24 [48.0%] females, and 35 [70.0%] patients with paroxysmal AF). The median procedure duration (IQR) was 77 (65; 96) minutes, and the median fluoroscopy time (IQR) was 17.7 (12.5; 22.0) min. PVI was successfully accomplished in each treated pulmonary vein (PV), with 87.4% of PVs isolated during the first freeze. The large balloon configuration was used to isolate 16.8% of PVs. Conclusions: The utilization of the size-adjustable CB, combined with the presented tailored ablation workflow, appears to facilitate effective and efficient pulmonary vein isolation. The use of a larger balloon configuration appears beneficial in isolating a significant proportion of the PVs.
Clinical Outcomes of Trimethoprim/Sulfamethoxazole in Critically Ill Patients with Stenotrophomonas maltophilia Bacteremia and Pneumonia Utilizing Renal Replacement Therapies
Authors: El Nekidy Wasim S. , Al Zaman Khaled , Abidi Emna , Alrahmany Diaa , Ghazi Islam M. , El Lababidi Rania , Mooty Mohamad , Hijazi Fadi , Ghosn Muriel , Askalany Mohamed , Helal Mohamed , Taha Ahmed , Ismail Khaled , Mallat Jihad
Published: April 2024

Background: The clinical outcomes of usual doses of Trimethoprim–sulfamethoxazole (TMP/SMZ) for treating S. maltophilia in critically ill patients on renal replacement therapies (RRT) have not been established. We sought to assess the clinical outcomes of TMP/SMZ in patients with sepsis utilizing RRT. Methods: A retrospective study was performed on all critically ill adult patients with S. maltophilia infections who received RRT between May 2015 and January 2022. The primary endpoint was clinical cure while the secondary endpoints were microbiologic cure, 30-day infection recurrence, and mortality. Results: Forty-five subjects met the inclusion criteria. The median age was 70.0 [interquartile range (IQR): 63.5–77] years, 57.8% were males, and the median body mass index was 25.7 [IQR: 22–30.2] kg/m2. Clinical success and failure were reported in 18 (40%) and 27 (60%) cases, respectively. There was no significant difference between the 30-day reinfection rates of both groups; however, mortality was significantly higher in the clinical failure group, involving 12 patients (44.4%), versus none in the clinical success group (p = 0.001). The median daily dose of TMP/SMZ upon continuous veno-venous hemofiltration was 1064 [IQR: 776–1380] mg in the clinical cure group vs. 768 [IQR:540–1200] mg in the clinical failure group (p = 0.035). Meanwhile, the median dose for those who received intermittent hemodialysis was 500 [IQR: 320–928] mg in the clinical success group compared to 640 [IQR: 360–1005] mg in the clinical failure group (p = 0.372). A total of 55% experienced thrombocytopenia, 42% hyperkalemia, and 2.2% neutropenia. The multivariable logistic regression analysis showed that the total daily dose at therapy initiation was the only independent factor associated with clinical success after adjusting for different variables including the body mass index [Odds ratio 1.004; 95% confidence interval: (1–1.007), p = 0.044]. Conclusions: Although the S. maltophilia isolates were reported as susceptible, TMP/SMZ with conventional doses to treat bacteremia and pneumonia in critically ill patients utilizing RRT was associated with high rates of clinical and microbiologic failure as well as with mortality. Larger outcomes and pharmacokinetics studies are needed to confirm our findings.
Spatial and Temporal Characteristics and Mechanisms of Marine Heatwaves in the Changjiang River Estuary and Its Surrounding Coastal Regions
Authors: Xie Minghong , Ji Qiyan , Zheng Qingdan , Meng Ziyin , Wang Yuting , Gao Meiling
Published: April 2024

Marine heatwave (MHW) events have significant consequences for marine ecosystems and human society. This paper investigates a MHW’s spatial–temporal characteristics in the Changjiang River Estuary and its surrounding coastal regions (CRESs), as well as analyzes the drivers, using satellite and reanalysis data spanning from 1982–2021. The findings show that, during the last 40 years, all four of the MHW indicators have increased. The summer MHW is more severe than other seasons, showing a rising pattern from southeast to northwest. The rise of MHWs can be attributed to the increase in sea surface heat flux, weak wind speed, and powerful El Niño events. Additionally, two special MHW events were detected during the entire study period: Event A lasted for 191 days from 9 October 2006 to 17 April 2007; Event B had an average intensity of 4.93 °C from 5 July 1994 to 1 August 1994. For locations so close to each other, the characteristics of MHWs can also vary, and the mechanisms behind them are highly complex.
Diversity of Arbuscular Mycorrhizal Fungi of the Rhizosphere of Lycium barbarum L. from Four Main Producing Areas in Northwest China and Their Effect on Plant Growth
Authors: Cheng Yuyao , Chen Kaili , He Dalun , He Yaling , Lei Yonghui , Sun Yanfei
Published: April 2024

Arbuscular mycorrhizal fungi (AMF) can help plants absorb more mineral nutrients after they colonize plant roots, and the mycelia harmonize the soil structure and physical and chemical properties by secreting compounds. AMF species co-evolve with their habitat’s geographic conditions and hosts; this gradually causes differences in the AMF species. By using Melzer’s reagent to analyze the morphology and using Illumina Miseq sequencing technology to perform the molecular identification of AMF communities among the four typical L. barbarum planting areas (Zhongning, Guyuan, Jinghe, and Dulan) investigated, the variety of L. barbarum roots and rhizosphere AMF communities was greater in the Zhongning area, and every region additionally had endemic species. The successfully amplified AMF was re-applied to the L. barbarum seedlings. We found that the total dry weight and accumulation of potassium increased significantly (p < 0.05), and the root volume and number of root branches were significantly higher in the plants that were inoculated with Paraglomus VTX00375 in the pot experiment, indicating that AMF improves root development and promotes plant growth. We have investigated AMF germplasm species in four regions, and we are committed to the development of native AMF resources. The multiplication and application of AMF will be conducive to realizing the potential role of biology in the maintenance of agroecology.
FgFAD12 Regulates Vegetative Growth, Pathogenicity and Linoleic Acid Biosynthesis in Fusarium graminearum
Authors: Zhang Yimei , Gao Zhen , Lei Yinyu , Song Liuye , He Weijie , Liu Jingrong , Song Mengge , Dai Yafeng , Yang Guang , Gong Andong
Published: April 2024

Polyunsaturated fatty acids (PUFAs), as important components of lipids, play indispensable roles in the development of all organisms. ∆12 fatty acid desaturase (FAD12) is a speed-determining step in the biosynthesis of PUFAs. Here, we report the characterization of FAD12 in Fusarium graminearum, which is the prevalent agent of Fusarium head blight, a destructive plant disease worldwide. The results demonstrated that deletion of the FgFAD12 gene resulted in defects in vegetative growth, conidial germination and plant pathogenesis but not sexual reproduction. A fatty acid analysis further proved that the deletion of FgFAD12 restrained the reaction of oleic acid to linoleic acid, and a large amount of oleic acid was detected in the cells. Moreover, the ∆Fgfad12 mutant showed increased resistance to osmotic stress and reduced tolerance to oxidative stress. The expression of FgFAD12 did show a temperature-dependent manner, which was not affected at a low temperature of 10 °C when compared to 25 °C. RNA-seq analysis further demonstrated that most genes enriched in fatty acid metabolism, the biosynthesis of unsaturated fatty acids, fatty acid biosynthesis, fatty acid degradation, steroid biosynthesis and fatty acid elongation pathways were significantly up-regulated in the ∆Fgfad12 mutants. Overall, our results indicate that FgFAD12 is essential for linoleic acid biosynthesis and plays an important role in the infection process of F. graminearum.
Fusarium, Scedosporium and Other Rare Mold Invasive Infections: Over Twenty-Five-Year Experience of a European Tertiary-Care Center
Authors: Ledoux Marie-Pierre , Dicop Elise , Sabou Marcela , Letscher-Bru Valérie , Castelain Vincent , Danion François , Herbrecht Raoul
Published: April 2024

Invasive mold infections (IMD) are an emerging concern due to the growing prevalence of patients at risk, encompassing but not limited to allogeneic hematopoietic stem cell transplant recipients, hematological malignancies patients, solid organ transplant recipients and intensive care unit patients. In contrast with invasive aspergillosis and mucormycosis, other hyalohyphomycoses and phaeohyphomycoses remain poorly known. We conducted a retrospective analysis of the clinical, biological, microbiological and evolutive features of 92 IMD having occurred in patients in our tertiary-care center over more than 25 years. A quarter of these infections were due to multiple molds. Molds involved were Fusarium spp. (36.2% of IMD with a single agent, 43.5% of IMD with multiple agents), followed by Scedosporium spp. (respectively 14.5% and 26.1%) and Alternaria spp. (respectively 13.0% and 8.7%). Mortality at day 84 was higher for Fusarium spp., Scedosporium spp. or multiple pathogens IMD compared with Alternaria or other pathogens (51.7% vs. 17.6%, p < 0.05). Mortality at day 84 was also influenced by host factor: higher among hematology and alloHSCT patients than in other patients (30.6% vs. 20.9% at day 42 and 50.0% vs. 27.9% at day 84, p = 0.041). Better awareness, understanding and treatments are awaited to improve patient prognosis.
A Discrete Risk-Theory Approach to Manage Equity-Linked Policies in an Incomplete Market
Authors: Della Corte Francesco , Marzorati Francesca
Published: April 2024

We construct a model where, at each time instance, risky securities can only take a limited number of values and the equity-linked policy sold by the insurer to policyholders pays benefits linked to these securities. Since the number of states in the model exceeds the number of securities in the (incomplete) market, the martingale measure is not unique, posing a problem in pricing insurance instruments. In this framework, we consider how a super-replicating strategy violates the assumption of absence of arbitrage, yet simultaneously allows the insurance company to fully hedge against financial risk. Since the super-replicating strategy, when considered alone, would be too costly for any rational insured person, through the definition of the safety loading, we demonstrate how the insurer can still hedge against financial risk, albeit at the expense of increasing its exposure to demographic risk. This approach does not aim to show how the pricing of the index-linked policy can actually be performed but rather highlights how risk theory-based approaches (via the definition of the profit and loss random variable) enable the management of the trade-off between financial risk and demographic risk.
Pathways to Success: The Interplay of Industry and Venture Capital Clusters in Entrepreneurial Company Exits
Authors: Ahluwalia Saurabh , Kassicieh Sul
Published: April 2024

This study investigates the dynamics within entrepreneurial ecosystems, focusing on the influence of venture capital (VC) financing clusters and industry clusters on startup success. VC financing clusters, geographic hubs with intense VC funding activities, and industry clusters, regions with concentrated sector-specific firms, are integral components. Expanding existing research that links proximity to these clusters with successful exits through mergers and acquisitions (M&A), our study includes initial public offerings (IPOs) as a vital exit strategy. Results show that affiliations with venture capitalists in prominent VC financing clusters enhance M&A and IPO success for startups. Intriguingly, startups in industry strongholds exhibit a greater likelihood of M&A success, but, this effect is not seen for IPO exits. Additionally, the absence of startup co-location with venture capitalists in VC financing hubs does not impact IPO exits but hinders M&A success. These nuanced insights highlight the complex relationships within entrepreneurial ecosystems and underscore the need for tailored perspectives considering diverse exit pathways.
Spatial–Temporal Pattern of Coordination between the Supply and Demand for Ecosystem Services in the Lhasa River Basin
Authors: Liu Jingyang , Wan Jia , Li Shirong , Shen Yuzhe , Han Wangya , Liu Guohua
Published: April 2024

Quantifying the spatiotemporal patterns of the coordination between ecosystem service supply and demand is vital for regional sustainable development. To reveal the dynamic pattern of the coordination of ecosystem service (ES) supply and demand in the Lhasa River Basin, we quantified the supply of the following four ESs using the InVEST model from 2000 to 2018: carbon sequestration (CS), water conservation (WC), habitat quality (HQ), and soil conservation (SC). Using socio-economic data, including land development degree, GDP, and population density, the ES demand was quantified. The ES supply–demand ratio (ESDR) and coupling coordination degree (CCD) model were used to evaluate the coupling relationship and coordination of ES supply and demand. The spatial autocorrelation analysis was used to determine the spatial correlation and changes in the ES supply–demand coupling coordination degree. The results indicate that the distribution of ESDR exhibited significant spatial heterogeneity. The area with ES supply far greater than demand was always in the upstream area of the Lhasa River, while the ES demand of Chengguan District far exceeded supply. Grasslands and forests were the main contributors to ESDRs, providing positive ESDRs for three services, SC, HQ, and WC, with a total proportion above 80%. From 2000 to 2018, the mismatch between ES supply and demand was gradually spreading upstream, while the upstream areas had a relatively high CCD. The spatial correlations of the CCD in the Lhasa River basin all showed statistically significant differences (p < 0.01). The high–high aggregation areas were concentrated in the northeast of the Lhasa River basin, while the low–low aggregation areas were centered around Chengguan District. This study provides reference values for optimizing the land use spatial patterns in ecologically vulnerable areas with the goal of sustainable development.
Revealing the Spatial Interactions and Driving Factors of Ecosystem Services: Enlightenments under Vegetation Restoration
Authors: Li Ting , Ren Yu , Ai Zemin , Qiao Zhihong , Ren Yanjiao , Ma Liyang , Yang Yadong
Published: April 2024

Large-scale vegetation restoration has caused complex changes in ecosystem service (i.e., ES) interactions. However, current analysis on the spatial interactions of ESs and their driving mechanisms remains deficient, limiting the adaptive management in vegetation restoration areas. This study focused on a representative restoration area (Yan’an) to analyze the relationships among carbon sequestration, water yield, baseflow regulation, and soil conservation from 1990 to 2020. Employing the bivariate boxplot and spatial autocorrelation methods, we identified the overall changes and spatial patterns of ES interactions. The geographically and temporally weighted regression (i.e., GTWR) model was applied to elucidate the driving factors of these spatial ES interactions. The results indicated the following: (1) Over the past three decades, synergies between carbon sequestration and water yield emerged as the joint results of spatial ‘low–low’ interactions and ‘high–high’ interactions between the two ESs, while other ES pairs generally exhibited comparatively weaker synergies, due to their spatial ‘low–high’ interactions in southern semi-humid areas. (2) In the northern semi-arid areas, both fractional vegetation cover (i.e., FVC) and climatic factors consistently exerted negative influences on all ‘low–low’ ES interactions, which caused a reduced area in synergies, while in the southern semi-humid areas, FVC suppressed the ‘low–high’ trade-offs between ESs, indicating the adaptability of grassland restoration efforts. (3) The impact of human activities on ES interactions has increased in the last 10 years, and exhibited positive effects on the ‘low–low’ ES interactions in northern semi-arid areas. However, the expansion of trade-off between soil conservation and carbon sequestration warrants attention. This study offers important insights into understanding the spatial interactions among carbon, water, and soil-related ESs in drylands.
Urban Matrices Threaten Patch Occurrence of Howler Monkeys in Anthropogenic Landscapes
Authors: Galán-Acedo Carmen , Hass Gabriela Pacheco , Klain Vinícius , Bencke Pedro , Bicca-Marques Júlio César
Published: April 2024

Habitat modification due to human activities threatens species survival. While some species can inhabit habitat patches in anthropogenic landscapes, their occurrence often depends on landscape structure. We assessed the effects of landscape structure on brown howler monkey (Alouatta guariba clamitans) occurrence in an urban scenario. We conducted censuses in 59 forest patches from 2014 to 2016 in Rio Grande do Sul State, Brazil. We evaluated patch occurrence (presence/absence) in response to landscape composition (forest cover, arboreal crops, urban areas, open areas, and water) and configuration (patch density), considering the scale of effect. Water, urban, and open areas were the most important predictors of howler presence. Their presence was notably higher in landscapes with more water, likely because these landscapes consist of rural areas with low urbanization, less farming, and relatively high forest cover. Presence of howlers was positively associated with forest cover and negatively related to urban areas, open areas, and arboreal crops. Resource scarcity and increased mortality risks from human pressures, such as domestic dog attacks, electrocution, and roadkill on these land covers may explain these relationships. We highlight the importance of conserving and increasing forest cover in anthropogenic landscapes to protect species reliant on forested habitats, like howler monkeys.
Effects of Urban Parks on Housing Prices in the Post-COVID-19 Pandemic Era in China
Authors: Yang Xinxing , Ye Qiang , Peng You , Liu Shaobo , Feng Tao
Published: April 2024

Urban parks are important for improving the quality of living environments. Although the impact of parks on housing prices has been well documented, the effects of the COVID-19 pandemic remain vague. This paper analyzes the housing prices of neighborhoods around Meixi Lake park in Changsha, at the initial stage of the COVID-19 pandemic in June 2020 and the stable stage of the recovery period in June 2023, which demonstrates the impacts of urban parks on property pricing and housing choice based on residential transaction data. The results indicate that urban parks are given a high priority in determining people’s choices. In June 2020, the risk of epidemic transmission and noise interference lowered the price of property that is close to public parks and recreational facilities. However, good management and social services in residential areas increase housing prices. However, when the pandemic ended, the strong demand for outdoor activities led to a price rise in the properties near Meixi Lake park. People are most likely to choose houses in a neighborhood characterized by good educational facilities and a high-quality living environment. More specially, the houses with a short distance to parks and where residents can enjoy the view of a lake or mountains are preferable to any others. A residential area adjacent to a super large park paired with a small park is the most valuable consideration for property developers and housing consumers.
Seasonal Response of the NDVI to the SPEI at Different Time Scales in Yinshanbeilu, Inner Mongolia, China
Authors: Wang Sinan , Xing Xigang , Wu Yingjie , Guo Jianying , Li Mingyang , Fu Bin
Published: April 2024

Recently, the frequent occurrence of droughts has caused a serious impact on vegetation growth and progression. This research is based upon the normalized difference vegetation index (NDVI) from 2001 to 2020. The correlation between the NDVI and standardized precipitation evapotranspiration index (SPEI) at disparate time scales was used to assess the response of vegetation growth to drought in the Yinshanbeilu region. The drought levels of SPEI1, SPEI3, SPEI6, and SPEI12 increased prominently in the eastern region of the country, while the NDVI decreased significantly from east to west in spring, summer, and autumn but was reversed in the winter. The area with an upward trend (33.86%) was slightly lower than that with a downward trend (66.14%). The correlation coefficients between the NDVI and SPEI over the entire year increased with the SPEI timescale. The elevated values were concentrated in the southeastern and western regions of the survey region. Additionally, the best correlation timescales were SPEI6 and SPEI12. Grassland was the most sensitive vegetation type to the SPEI response in the NDVI. The correlation coefficients of NDVI and SPEI1–12 were 0.313, 0.459, 0.422, and 0.406. Both spring and summer were more responsive to SPEI12, whereas autumn and winter were more responsive to SPEI3. The correlation of disparate time scales exhibited complex soil texture features with respect to different seasonal scales, and the soil texture showed a strong response to vegetation in both summer and autumn. Loam, sandy loam, and silty loam all exhibited the highest response to SPEI12, with coefficients of 0.509, 0.474, and 0.403, respectively.
“Dime con Quién Andas y te Diré Qué Piensas Sobre el Español de los US”: Language Attitudes and Motivation to Learn Spanish as a Heritage Language through the Lens of Social Networks
Authors: Cuartero Marco Marina
Published: April 2024

This study explores the motivation and attitudes of heritage speakers (HSs) of Spanish, focusing on the influence of their social networks. Previous research highlighted variations in HS motivation, attributed to social, cultural, and contextual factors. The study investigates how HS communities shape motivation and attitudes towards learning the heritage language (HL). Employing personal network analysis, the research surveyed 26 Spanish HSs in a Spanish heritage language program. Results revealed that HS networks primarily consisted of emotionally close family members. Positive and negative factors within these networks, such as language support, confidence, shame, and expectations, significantly influenced HS motivation and attitudes. Language attitudes within the network positively impacted individual attitudes, indicating a process of internalizing shared values. The study emphasizes the importance of considering the context surrounding HSs and suggests that addressing language expectations and fostering language support in communities may positively transform perceptions of Spanish in the United States. The findings underscore the effectiveness of a personal network approach in recreating the external environment beyond the language classroom.
NN and VV Coordinate Compounds
Authors: Nagano Akiko , Shimada Masaharu
Published: April 2024

Broadly speaking, binominal and biverbal lexical constructions have been studied independently in different research traditions and frameworks. It is true that the two do not necessarily have overlapping areal distributions, but the fundamental question remains whether Indo-European NN compounds and Transeurasian VV compounds have nothing in common. Against this background, a cross-categorial comparison, not within but across languages, is made of coordinative binominal and biverbal constructions. NN and VV coordinate compounds from English and Japanese are examined in detail using the methodology of contrastive morphology and decompositional lexical semantics. It is shown that dvandva is possible not only in NN but also in VV coordinate compounds and, furthermore, that the dvandva–appositive distinction in NN coordinate compounds recurs in VV coordinate compounds. Cross-categorial formal analyses of the two types, i.e., dvandva and appositive, are presented in the Lexical Semantic Framework.
Scissor Arm for Cambered Snow: Mechanical Theory
Authors: Gang Shuang , Gong Zhanran , Li Yiming , Liu Yu , Liu Xingan , Li Tianlai
Published: April 2024

In this study, a novel cambered snow removal device is designed to achieve automatic snow removal in large curved areas, such as the south roof of a Chinese solar greenhouse. The theory of structural parameters and shear force is ambiguous. People are not based on the greenhouse structure parameters for the selection of snow removal devices. Therefore, the quantitative relationship between the structure of the greenhouse span and the number of scissor arm-length knots is analysed, and the relationship between the material strength and application distance is determined. This study’s objectives are (1) to establish a theoretical model of scissor arm motion and (2) to analyse the force distribution of the scissor arm using multi-body dynamics. The results show that the scissor arm of a round-arch greenhouse has fewer sections but a larger arm length, whereas the scissor arm of a traditional solar greenhouse has more sections but a smaller arm length. Based on the shear force of the scissor structure, the optimised wall thickness reduces the force of the node by 17%.
Correction: Gautam et al. Experimental Thermal Conductivity Studies of Agar-Based Aqueous Suspensions with Lignin Magnetic Nanocomposites. Magnetochemistry 2024, 10, 12
Authors: Gautam Bishal , Nabat Al-Ajrash Saja M. , Hasan Mohammad Jahid , Saini Abhishek , Watzman Sarah J. , Ureña-Benavides Esteban , Vasquez-Guardado Erick S.
Published: April 2024

In the original publication [...]