bluuebunny/crossref_metadata_2025 huggingface dataset:
Validation of a Process-Based Agro-Ecosystem Model (Agro-IBIS) for Maize in Xinjiang, Northwest China
Authors: Amuti Tureniguli , Luo Geping , Yin Gang , Hu Qi , Walter-Shea E.
Published: March 2018

Agricultural oasis expansion and intensive management practices have occurred in arid and semiarid regions of China during the last few decades. Accordingly, regional carbon and water budgets have been profoundly impacted by agroecosystems in these regions. Therefore, study on the methods used to accurately estimate energy, water, and carbon exchanges is becoming increasingly important. Process-based models can represent the complex processes between land and atmosphere among agricultural ecosystems. However, before the models can be applied they must be validated under different environmental and climatic conditions. In this study, a process-based agricultural ecosystem model (Agro-IBIS) was validated for maize crops using 3 years of soil and biometric measurements at Wulanwusu agrometeorological site (WAS) located in the Shihezi oasis in Xinjiang, northwest China. The model satisfactorily represented leaf area index (LAI) during the growing season, simulating its peak values within the magnitude of 0–10%. The total biomass carbon was overestimated by 15%, 8%, and 16% in 2004, 2005, and 2006, respectively. The model satisfactorily simulated the soil temperature (0–10 cm) and volumetric water content (VWC) (0–25 cm) of farmland during the growing season. However, it overestimated soil temperature approximately by 4 °C and VWC by 15–30% during the winter, coinciding with the period of no vegetation cover in Xinjiang. Overall, the results indicate that the model could represent crop growth, and seems to be applicable in multiple sites in arid oases agroecosystems of Xinjiang. Future application of the model will impose more comprehensive validation using eddy covariance flux data, and consider including dynamics of crop residue and improving characterization of the final stage of leaf development.
Potassium: A Vital Regulator of Plant Responses and Tolerance to Abiotic Stresses
Authors: Hasanuzzaman Mirza , Bhuyan M. , Nahar Kamrun , Hossain Md. , Mahmud Jubayer , Hossen Md. , Masud Abdul , Moumita  , Fujita Masayuki
Published: March 2018

Among the plant nutrients, potassium (K) is one of the vital elements required for plant growth and physiology. Potassium is not only a constituent of the plant structure but it also has a regulatory function in several biochemical processes related to protein synthesis, carbohydrate metabolism, and enzyme activation. Several physiological processes depend on K, such as stomatal regulation and photosynthesis. In recent decades, K was found to provide abiotic stress tolerance. Under salt stress, K helps to maintain ion homeostasis and to regulate the osmotic balance. Under drought stress conditions, K regulates stomatal opening and helps plants adapt to water deficits. Many reports support the notion that K enhances antioxidant defense in plants and therefore protects them from oxidative stress under various environmental adversities. In addition, this element provides some cellular signaling alone or in association with other signaling molecules and phytohormones. Although considerable progress has been made in understanding K-induced abiotic stress tolerance in plants, the exact molecular mechanisms of these protections are still under investigation. In this review, we summarized the recent literature on the biological functions of K, its uptake, its translocation, and its role in plant abiotic stress tolerance.
Influence of Vitamin C on Lymphocytes: An Overview
Authors: Van Gorkom Gwendolyn , Klein Wolterink Roel , Van Elssen Catharina , Wieten Lotte , Germeraad Wilfred , Bos Gerard
Published: March 2018

Vitamin C or ascorbic acid (AA) is implicated in many biological processes and has been proposed as a supplement for various conditions, including cancer. In this review, we discuss the effects of AA on the development and function of lymphocytes. This is important in the light of cancer treatment, as the immune system needs to regenerate following chemotherapy or stem cell transplantation, while cancer patients are often AA-deficient. We focus on lymphocytes, as these white blood cells are the slowest to restore, rendering patients susceptible to often lethal infections. T lymphocytes mediate cellular immunity and have been most extensively studied in the context of AA biology. In vitro studies demonstrate that T cell development requires AA, while AA also enhances T cell proliferation and may influence T cell function. There are limited and opposing data on the effects of AA on B lymphocytes that mediate humoral immunity. However, AA enhances the proliferation of NK cells, a group of cytotoxic innate lymphocytes. The influence of AA on natural killer (NK) cell function is less clear. In summary, an increasing body of evidence indicates that AA positively influences lymphocyte development and function. Since AA is a safe and cheap nutritional supplement, it is worthwhile to further explore its potential benefits for immune reconstitution of cancer patients treated with immunotoxic drugs.
Core@shell Nanoparticles: Greener Synthesis Using Natural Plant Products
Authors: Khatami Mehrdad , Alijani Hajar , Nejad Meysam , Varma Rajender
Published: March 2018

Among an array of hybrid nanoparticles, core-shell nanoparticles comprise of two or more materials, such as metals and biomolecules, wherein one of them forms the core at the center, while the other material/materials that were located around the central core develops a shell. Core-shell nanostructures are useful entities with high thermal and chemical stability, lower toxicity, greater solubility, and higher permeability to specific target cells. Plant or natural products-mediated synthesis of nanostructures refers to the use of plants or its extracts for the synthesis of nanostructures, an emerging field of sustainable nanotechnology. Various physiochemical and greener methods have been advanced for the synthesis of nanostructures, in contrast to conventional approaches that require the use of synthetic compounds for the assembly of nanostructures. Although several biological resources have been exploited for the synthesis of core-shell nanoparticles, but plant-based materials appear to be the ideal candidates for large-scale green synthesis of core-shell nanoparticles. This review summarizes the known strategies for the greener production of core-shell nanoparticles using plants extract or their derivatives and highlights their salient attributes, such as low costs, the lack of dependence on the use of any toxic materials, and the environmental friendliness for the sustainable assembly of stabile nanostructures.
Capture Effect in the FSA-Based Networks under Rayleigh, Rician and Nakagami-m Fading Channels
Authors: Wang Yang , Shi Jianghong , Chen Lingyu
Published: March 2018

Framed slotted aloha (FSA) is a multiple access protocol widely used in wireless communication for its simplicity and effectivity. The theoretical maximum channel utilization of FSA is approximately equal to 0.37 irrespective of the capture effect. In fact, the capture effect is a common phenomenon in wireless communication, which can increase the channel utilization. In this paper, we derive the closed-form expressions of capture probabilities under Rayleigh, Rician and Nakagami-m fading channels, respectively, and further give the optimal frame length which maximizes the channel utilization in the FSA-based networks. The numerical results are given for indicating the capture probabilities under different fading channels and their impacts on the optimal frame length and the maximum channel utilization.
Fatigue Resistance Evaluation of Modified Asphalt Using a Multiple Stress Creep and Recovery (MSCR) Test
Authors: Zhang Weiguang , Ma Tao , Xu Gang , Huang Xiaoming , Ling Meng , Chen Xiao , Xue Jiayue
Published: March 2018

Fatigue resistance quantification of modified asphalt is typically time consuming and may not correlate well with mixture fatigue test results. In this paper, the applicability of a multiple stress creep and recovery (MSCR) test on asphalt binder’s fatigue resistance was evaluated. Six binder types with a variety of modifiers and different modifier contents were characterized. The MSCR test was conducted and its sensitivity to binder type and additive content under different aging durations was evaluated. Mixture fatigue tests including a semi-circular bending- Illinois flexibility index test and indirect tensile strength were conducted using control base asphalt and SBS modified asphalt. A ranking between the binder MSCR and mixture fracture test results was conducted to check if the MSCR result was representative of the mixture’s fatigue resistance. Results indicate that the MSCR test at intermediate temperatures (20 °C, 25 °C, and 30 °C) can be performed with good repetitions. It was also found that the MSCR test was sensitive enough to differentiate the fatigue resistance among different binder types and additive contents. The ranking analysis shows that the binder MSCR test at intermediate temperatures showed a similar ranking to the mixture’s fatigue tests, indicating that the binder MSCR test could be potentially utilized to represent a mixture’s fatigue resistance where binder selection is a major concern. It was also found that the SBS modified binder showed the best crack resistance and was less affected by aging.
Molecular Characterization and Theoretical Calculation of Plant Growth Regulators Based on Terahertz Time-Domain Spectroscopy
Authors: Qu Fangfang , Lin Lei , Cai Chengyong , Dong Tao , He Yong , Nie Pengcheng
Published: March 2018

Terahertz (THz), as an advanced spectral technology, has unique absorption characteristics for most biological macromolecules. In this work, the theoretical fundamentals for the application of THz time-domain spectroscopy (THz-TDS) to molecular characterization and fingerprint peak detection of three plant growth regulators (PGRs), including 2,4-Dichlorophenoxyacetic acid (2,4-D), forchlorfenuron (CPPU) and indole-3-acetic acid (IAA) were researched. Meanwhile, the effects of eight types of window functions on THz spectra were studied when converting time-domain spectra into frequency-domain spectra by Fourier transform. Based on the optimal window function, the THz absorption coefficient and refractive index of PGRs in frequencies of 0.2–3 THz were extracted. The molecule structure and vibration mode of three PGR samples were simulated by using density functional theory (DFT). The results showed that the three PGRs had different fingerprint peaks. Characteristic absorption and anomalous dispersion of 2,4-D were found at 1.35, 1.57 and 2.67 THz, those of CPPU were found at 1.77 and 2.44 THz, and the absorption peak of IAA was located at 2.5 THz. The absorption peaks obtained from THz spectra were identified according to the theoretical calculation results of DFT. These fingerprint peaks in THz spectra were generated by the interior stretching vibration and external deformation vibration of molecular groups. The experimental results revealed the feasibility of identifying PGRs species and detecting residues using THz-TDS.
Implications of Rigid Gripping Constraints on Clubhead Dynamics in Steel Golf Shafts
Authors: Corke Tom , Betzler Nils , Wallace Eric , Strangwood Martin , Otto Steve
Published: March 2018

Research and equipment testing with golf robots offers much greater control and manipulation of experimental variables compared to tests using human golfers. However, whilst it is acknowledged that the club gripping mechanism of a robot is dissimilar to that of a human, there appears to be no scientific findings on the effects of these gripping differences on the clubhead at ball impact. Theoretical and experimental strain propagation rates from the clubhead to the grip and back to the clubhead were determined during robot testing with a 9-iron to determine if this time interval was sufficiently short to permit the gripping mechanism to have an effect on the clubhead during impact. Longitudinal strain appears to propagate the most quickly, but such deflections are likely to be small and therefore of little meaningful consequence. Shaft bending was not a primary concern as modes of large enough amplitude appear to propagate too slowly to be relevant. Torsional strain propagates at a rate which suggests that constraints at the grip end of a golf club could potentially influence impact dynamics for steel shafted irons; however, this effect seems unlikely to be significant, a likelihood that decreases further for longer irons. As such, it is considered reasonable to treat the influence of a robot’s gripping mechanism on clubhead dynamics at impact as negligible, and therefore comparisons between robot and human data in this regard are valid.
Temperature-Dependent Electrical Properties of Al2O3-Passivated Multilayer MoS2 Thin-Film Transistors
Authors: Jeong Seok , Liu Na , Park Heekyeong , Hong Young , Kim Sunkook
Published: March 2018

It is becoming more important for electronic devices to operate stably and reproducibly under harsh environments, such as extremely low and/or high temperatures, for robust and practical applications. Here, we report on the effects of atomic-layer-deposited (ALD) aluminum oxide (Al2O3) passivation on multilayer molybdenum disulfide (MoS2) thin-film transistors (TFTs) and their temperature-dependent electrical properties, especially at a high temperature range from 293 K to 380 K. With the aid of ultraviolet-ozone treatment, an Al2O3 layer was uniformly applied to cover the entire surface of MoS2 TFTs. Our Al2O3-passivated MoS2 TFTs exhibited not only a dramatic reduction of hysteresis but also enhancement of current in output characteristics. In addition, we investigated the temperature-dependent behaviors of the TFT performance, including intrinsic carrier mobility based on the Y-function method.
Real Estate Economics, Management and Investments: New Perspectives and Frontiers
Authors: Del Giudice Vincenzo , De Paola Pierfrancesco
Published: March 2018

New perspectives and frontiers were highlighted in a Special Issue on “Real Estate Economics, Finance and Investments”. The twenty-eight papers that were selected and published emanated from scholars from universities all over the world with the aim to represent more recent advances in building management, mass appraisal methods, real estate risk management, economic evaluation of real estate investment projects, real estate market, property, social housing, real estate economics, real estate finance, building transformation and economic effects on environment. These papers helped to determine a unique and valuable opportunity to experiment with multiple approaches to these ever more crucial topics. This note proposes a brief review of the twenty-eight papers, concluding with some reflections about policy, practice and research on real estate issues.
An Investigation into the Relationship among Psychiatric, Demographic and Socio-Economic Variables with Bayesian Network Modeling
Authors: Bilek Gunal , Karaman Filiz
Published: March 2018

The aim of this paper is to investigate the factors influencing the Beck Depression Inventory score, the Beck Hopelessness Scale score and the Rosenberg Self-Esteem score and the relationships among the psychiatric, demographic and socio-economic variables with Bayesian network modeling. The data of 823 university students consist of 21 continuous and discrete relevant psychiatric, demographic and socio-economic variables. After the discretization of the continuous variables by two approaches, two Bayesian networks models are constructed using the b n l e a r n package in R, and the results are presented via figures and probabilities. One of the most significant results is that in the first Bayesian network model, the gender of the students influences the level of depression, with female students being more depressive. In the second model, social activity directly influences the level of depression. In each model, depression influences both the level of hopelessness and self-esteem in students; additionally, as the level of depression increases, the level of hopelessness increases, but the level of self-esteem drops.
Sustainability Performance of an Italian Textile Product
Authors: Lenzo Paola , Traverso Marzia , Mondello Giovanni , Salomone Roberta , Ioppolo Giuseppe
Published: March 2018

Companies are more and more interested in the improvement of sustainability performance of products, services and processes. For this reason, appropriate and suitable assessment tools supporting the transition to a green economy are highly necessary. Currently, there are a number of methods and approaches for assessing products’ environmental impact and improving their performances; among these, the Life Cycle Thinking (LCT) approach has emerged as the most comprehensive and effective to achieve sustainability goals. Indeed, the LCT approach aims to reduce the use of resources and emissions to the environment associated with a product’s life cycle. It can be used as well to improve socio-economic performance through the entire life cycle of a product. Life Cycle Assessment (LCA), Life Cycle Costing (LCC) and Social Life Cycle Assessment (S-LCA) are undoubtedly the most relevant methodologies to support product-related decision-making activities for the extraction and processing of raw materials, manufacturing, distribution, use, reuse, maintenance, recycling and final disposal. While LCA is an internationally standardized tool (ISO 14040 2006), LCC (except for the ISO related to the building sector) and S-LCA have yet to attain international standardization (even if guidelines and general frameworks are available). The S-LCA is still in its experimental phase for many aspects of the methodological structure and practical implementation. This study presents the application of LCA and S-LCA to a textile product. The LCA and S-LCA are implemented following the ISO 14040-44:2006 and the guidelines from UNEP/SETAC (2009), respectively. The functional unit of the study is a cape knitted in a soft blend of wool and cashmere produced by a textile company located in Sicily (Italy). The system boundary of the study includes all phases from cradle-to-gate, from raw material production through fabric/accessory production to the manufacturing process of the product itself at the Sicilian Company. Background and foreground processes are taken into account using primary and secondary data. The analysis evaluates the environmental and social performances related to the specific textile product, but also outlines the general behaviour of the company. The case study also highlights pro and cons of a combined LCA and S-LCA to a textile product in a regional context.
New Wafer Alignment Process Using Multiple Vision Method for Industrial Manufacturing
Authors: KIM Jongwon
Published: March 2018

In semiconductor manufacturing, wafer aligners have been widely used, such as the conventional alignment method using a Charge Coupled Device (CCD) transmission sensor to detect the notch or flat in a wafer. This paper presents a proposed vision aligner using a vision method that can be installed in the wafer and plate bonding machine for mass production. The vision system, which uses three cameras to perform wafer alignment of position and rotation, detects wafer face side and ultraviolet (UV) tape on the target wafer and plate. It can be utilized for the alignment process of wafers and ceramic plate bonding. Using the vision method, the aligner could reduce the process steps and time required for wafer bonding, as well as unexpected problems caused by the workers during manufacturing. The system was applied in the mass production field to verify its performance.
Combined Use of Remote Sensing Data, Mineralogical Analyses, Microstructure Studies and Geographic Information System for Geological Mapping of Antiparos Island (Greece)
Authors: Nikolakopoulos Konstantinos , Lampropoulou Paraskevi , Papoulis Dimitrios , Rogkala Aikaterini , Giannakopoulou Panagiota , Petrounias Petros
Published: March 2018

This study presents the combined use of field mapping, remote sensing data analysis, mineralogy, spectroscopy and GIS techniques for the geological mapping of Antiparos Island. Antiparos is part of the Cyclades Blueschist Belt located in central Aegean, where gneisses, schists and Pliocene volcanic rocks occurred. During the extended field work, a number of volcanic rock samples were collected from the southern part of Antiparos. The sampling strategy was to collect samples from the primary as well as the altered rocks in specific areas in which they were previously located from the remote sensing data processing. In this study, high resolution satellite images have been carried out in order to detect, allocate and separate the different geological formations. Furthermore, the existing geological map was georeferenced and all the tectonic lines and boundaries were digitized. All these features were implemented in a Mobile Mapper CE GPS using Arcpad GIS and checked in situ. The collected samples were analyzed in the laboratory using various techniques including XRD, Petrographic Microscopy and SEM. The qualitative mineralogical analyses were conducted by using XRD. The study was supplemented by the petrographic observations providing a detailed characterization of rock textures. In addition, SEM study and SEM-EDS analyses of the samples were emphasized on the genetic relations of the minerals. The laboratory results revealed that specific corrections should be made in the previous geological map of Antiparos concerning the volcanic rocks, especially at the southern part of the island. A significant conclusion is that the rock described as volcanic in the previous map proved to be a fossiliferous limestone which includes micritic matrix of calcite with an insignificant amount of fossils. All the analogical and digital data and the results of the petrographic analysis were imported in a geodatabase specially designed for geological data. After the necessary topological control and corrections, the data were unified and processed in order to create the final layout at 1/25.000 scale.
The Self without Character: Melville’s The Confidence-Man and Murakami’s Kafka on the Shore
Authors: Wirth Jason
Published: March 2018

This essay explores the gap between character, that is, the habitual persona or mask that can be consistently recognized and represented, and the underlying self. If the self is conflated with the persona, the latter rings hollow. If the self emerges in the gap between itself and its persona, it is no longer hollow but rather empty in the positive Mahāyāna Buddha Dharma sense of śūnyatā (lack of a self-same self or identity). This essay disambiguates the hollowness of character from the emptiness of the self through a study of Melville’s The Confidence-Man: His Masquerade (1857) and Murakami’s contemporary classic, Kafka on the Shore (2002). Bringing Murakami into proximity with Melville not only highlights the originality of both but also affords a co-illuminating confrontation that brings Buddhist and Shinto insights to bear upon the problem of the self.
Value Investing and Size Effect in the South Korean Stock Market
Authors: Perez Gerardo “Gerry” Alfonso
Published: March 2018

There are indications that value investing strategies have been able to outperform the overall market in several countries across the globe. In this article, the specific case of South Korea is analyzed. It would appear that from a rigorous statistical point of view there are no strong evidence supporting the outperformance of value stocks versus growth stocks in South Korea, particularly when measured on a yearly basis. These results were consistent using both MSCI value and growth indexes as well as constructing portfolios using the P/E, P/B, cash flow per share and average 5-year sales growth. The statistical tests performed failed to reject for the majority of the years that the monthly returns come from distributions with different medians. The test yielding rather consistent results on a yearly basis but for large periods of time (decades) the results were more mixed, pointing in some cases to value investing outperforming over that very long time frame. It should be noted that the final value of the portfolios was rather different when using criteria, such as low P/E, typically associated with value stocks. The tests also failed to reject the hypothesis of different means for the monthly returns of small, medium and large companies.
Augmented Virtuality for Coastal Management: A Holistic Use of In Situ and Remote Sensing for Large Scale Definition of Coastal Dynamics
Authors: Bartolini Sandro , Mecocci Alessandro , Pozzebon Alessandro , Zoppetti Claudia , Bertoni Duccio , Sarti Giovanni , Caiti Andrea , Costanzi Riccardo , Catani Filippo , Ciampalini Andrea , Moretti Sandro
Published: March 2018

In this paper, the authors describe the architecture of a multidisciplinary data acquisition and visualization platform devoted to the management of coastal environments. The platform integrates heterogeneous data acquisition sub-systems that can be roughly divided into two main categories: remote sensing systems and in situ sensing systems. Remote sensing solutions that are going to be implemented include aerial and underwater data acquisition while in situ sensing solutions include the use of Radio Frequency IDentification (RFID) tracers, Wireless Sensor Networks and imaging techniques. All the data collected by these subsystems are stored, integrated and fused on a single platform that is also in charge of data visualization and analysis. This last task is carried out according to the paradigm of Augmented Virtuality that foresees the augmentation of a virtually reconstructed environment with data collected in the real world. The described solution proposes a novel holistic approach where different disciplines concur, with different data acquisition techniques, to a large scale definition of coastal dynamics, in order to better describe and face the coastal erosion phenomenon. The overall framework has been conceived by the so-called Team COSTE, a joint research team between the Universities of Pisa, Siena and Florence.
Type 1 Diabetes and Its Multi-Factorial Pathogenesis: The Putative Role of NK Cells
Authors: Marca Valeria , Gianchecchi Elena , Fierabracci Alessandra
Published: March 2018

Type 1 diabetes (T1D) affects millions of people worldwide and is the prevalent form of all pediatric diabetes diagnoses. T1D is recognized to have an autoimmune etiology, since failure in specific self-tolerance mechanisms triggers immune reactions towards self-antigens and causes disease onset. Among all the different immunocytes involved in T1D etiopathogenesis, a relevant role of natural killer cells (NKs) is currently emerging. NKs represent the interface between innate and adaptive immunity; they intervene in the defense against infections and present, at the same time, typical features of the adaptive immune cells, such as expansion and generation of memory cells. Several recent studies, performed both in animal models and in human diabetic patients, revealed aberrations in NK cell frequency and functionality in the peripheral blood and in damaged tissues, suggesting their possible redirection towards affected tissues. NKs oscillate from a quiescent to an activated state through a delicate balance of activating and inhibitory signals transduced via surface receptors. Further accurate investigations are needed to elucidate the exact role of NKs in T1D, in order to develop novel immune-based therapies able to reduce the disease risk or delay its onset.
Chemotherapeutic-Induced Cardiovascular Dysfunction: Physiological Effects, Early Detection—The Role of Telomerase to Counteract Mitochondrial Defects and Oxidative Stress
Authors: Quryshi Nabeel , Norwood Toro Laura , Ait-Aissa Karima , Kong Amanda , Beyer Andreas
Published: March 2018

Although chemotherapeutics can be highly effective at targeting malignancies, their ability to trigger cardiovascular morbidity is clinically significant. Chemotherapy can adversely affect cardiovascular physiology, resulting in the development of cardiomyopathy, heart failure and microvascular defects. Specifically, anthracyclines are known to cause an excessive buildup of free radical species and mitochondrial DNA damage (mtDNA) that can lead to oxidative stress-induced cardiovascular apoptosis. Therefore, oncologists and cardiologists maintain a network of communication when dealing with patients during treatment in order to treat and prevent chemotherapy-induced cardiovascular damage; however, there is a need to discover more accurate biomarkers and therapeutics to combat and predict the onset of cardiovascular side effects. Telomerase, originally discovered to promote cellular proliferation, has recently emerged as a potential mechanism to counteract mitochondrial defects and restore healthy mitochondrial vascular phenotypes. This review details mechanisms currently used to assess cardiovascular damage, such as C-reactive protein (CRP) and troponin levels, while also unearthing recently researched biomarkers, including circulating mtDNA, telomere length and telomerase activity. Further, we explore a potential role of telomerase in the mitigation of mitochondrial reactive oxygen species and maintenance of mtDNA integrity. Telomerase activity presents a promising indicator for the early detection and treatment of chemotherapy-derived cardiac damage.
cGMP Signaling in the Cardiovascular System—The Role of Compartmentation and Its Live Cell Imaging
Authors: Bork Nadja , Nikolaev Viacheslav
Published: March 2018

The ubiquitous second messenger 3′,5′-cyclic guanosine monophosphate (cGMP) regulates multiple physiologic processes in the cardiovascular system. Its intracellular effects are mediated by stringently controlled subcellular microdomains. In this review, we will illustrate the current techniques available for real-time cGMP measurements with a specific focus on live cell imaging methods. We will also discuss currently accepted and emerging mechanisms of cGMP compartmentation in the cardiovascular system.
Diabetes Mellitus and Ischemic Heart Disease: The Role of Ion Channels
Authors: Severino Paolo , D’Amato Andrea , Netti Lucrezia , Pucci Mariateresa , De Marchis Marialaura , Palmirotta Raffaele , Volterrani Maurizio , Mancone Massimo , Fedele Francesco
Published: March 2018

Diabetes mellitus is one the strongest risk factors for cardiovascular disease and, in particular, for ischemic heart disease (IHD). The pathophysiology of myocardial ischemia in diabetic patients is complex and not fully understood: some diabetic patients have mainly coronary stenosis obstructing blood flow to the myocardium; others present with coronary microvascular disease with an absence of plaques in the epicardial vessels. Ion channels acting in the cross-talk between the myocardial energy state and coronary blood flow may play a role in the pathophysiology of IHD in diabetic patients. In particular, some genetic variants for ATP-dependent potassium channels seem to be involved in the determinism of IHD.
Cytotoxic and Apoptotic Activity of the Novel Harmine Derivative ZC-14 in Sf9 Cells
Authors: Zhang Jingjing , Zhang Zhijun , Shu Benshui , Cui Gaofeng , Zhong Guohua
Published: March 2018

Harmine, one of the natural β-carboline alkaloids extracted from Peganum harmala L., exhibits broad spectrum but limited insecticidal ability against many pests. So there is an urgent need to synthesize novel derivatives with high efficiency. In the present study, a new synthetic compound, [1-(2-naphthyl)-3-(2-thioxo-1,3,4-oxadiazol-5-yl) β-carboline] (ZC-14), showed a strong proliferation inhibition effect against the Spodoptera frugiperda Sf9 cell line in a dose-dependent manner. Simultaneously, apoptosis induced by 7.5 μg/mL ZC-14 was confirmed with physiological and biochemical evidence, including typical apoptosis characteristics with shrinkage, apoptotic bodies, nuclear condensation/fragmentation, a clear DNA ladder, and a series of apoptotic rates. In addition, mitochondria were confirmed to be involved in apoptosis induced by ZC-14 accompanied with the loss of mitochondrial membrane potential (Δψm), the release of cytochrome c from mitochondria into the cytosol and increased expression of cleaved-caspase-3. However, harmine could not induce apoptosis at the same concentration. In summary, these data indicated that compound ZC-14 has a higher cytotoxicity than harmine against Sf9 cells. Besides, it exhibited an anti-proliferative effect in Sf9 cells via inducing apoptosis in which the mitochondrial apoptotic pathway plays a crucial role.
Regulation of T-Cell Signaling by Post-Translational Modifications in Autoimmune Disease
Authors: Kuwabara Taku , Matsui Yukihide , Ishikawa Fumio , Kondo Motonari
Published: March 2018

The adaptive immune system involves antigen-specific host defense mechanisms mediated by T and B cells. In particular, CD4+ T cells play a central role in the elimination of pathogens. Immunological tolerance in the thymus regulates T lymphocytes to avoid self-components, including induction of cell death in immature T cells expressing the self-reactive T-cell receptor repertoire. In the periphery, mature T cells are also regulated by tolerance, e.g., via induction of anergy or regulatory T cells. Thus, T cells strictly control intrinsic signal transduction to prevent excessive responses or self-reactions. If the inhibitory effects of T cells on these mechanisms are disrupted, T cells may incorrectly attack self-components, which can lead to autoimmune disease. The functions of T cells are supported by post-translational modifications, particularly phosphorylation, of signaling molecules, the proper regulation of which is controlled by endogenous mechanisms within the T cells themselves. In recent years, molecular targeted agents against kinases have been developed for treatment of autoimmune diseases. In this review, we discuss T-cell signal transduction in autoimmune disease and provide an overview of acetylation-mediated regulation of T-cell signaling pathways.
Monitoring Quality-of-Life Parameters in Wearable Environments
Authors: Angelidis Pantelis
Published: March 2018

The paper presents a new cross-layer bridge protocol between IEEE 802.15.4, IEEE 11073 and IEEE 802.11 for wearable-enabled health-data aggregation formations. The protocol addresses the new reality as imposed by the recent evolution of sensors and networking in situations where backbone infrastructure is experiencing congestion. We discuss real-life application scenarios of nimble-network formations. The main novelty of the proposed algorithm is that it defines presence as a new way of routing.
Safety, Efficacy and Evidence Base for Use of the Subcutaneous Implantable Cardioverter Defibrillator
Authors: Adduci Carmen , Palano Francesca , Francia Pietro
Published: March 2018

The trans-venous implantable cardioverter defibrillator (TV-ICD) is effective in treating life-threatening ventricular arrhythmia and reduces mortality in high-risk patients. However, there are significant short- and long-term complications that are associated with intravascular leads. These shortcomings are mostly relevant in young patients with long life expectancy and low risk of death from non-arrhythmic causes. Drawbacks of trans-venous leads recently led to the development of the entirely subcutaneous implantable cardioverter defibrillator (S-ICD). The S-ICD does not require vascular access or permanent intravascular defibrillation leads. Therefore, it is expected to overcome many complications associated with conventional ICDs. This review highlights data on safety and efficacy of the S-ICD and is envisioned to help in identifying the role of this device in clinical practice.
The Cells of the Islets of Langerhans
Authors: Da Silva Xavier Gabriela
Published: March 2018

Islets of Langerhans are islands of endocrine cells scattered throughout the pancreas. A number of new studies have pointed to the potential for conversion of non-β islet cells in to insulin-producing β-cells to replenish β-cell mass as a means to treat diabetes. Understanding normal islet cell mass and function is important to help advance such treatment modalities: what should be the target islet/β-cell mass, does islet architecture matter to energy homeostasis, and what may happen if we lose a particular population of islet cells in favour of β-cells? These are all questions to which we will need answers for islet replacement therapy by transdifferentiation of non-β islet cells to be a reality in humans. We know a fair amount about the biology of β-cells but not quite as much about the other islet cell types. Until recently, we have not had a good grasp of islet mass and distribution in the human pancreas. In this review, we will look at current data on islet cells, focussing more on non-β cells, and on human pancreatic islet mass and distribution.
Chiefs in a Democracy: A Case Study of the ‘New’ Systems of Regulating Firewood Harvesting in Post-Apartheid South Africa
Authors: Findlay Sarah , Twine Wayne
Published: March 2018

Much of the international commons literature reveals a decreased functioning of local traditional institutions that regulate natural resource harvesting. In South Africa, it is believed that the creation of new democratic structures at the end of Apartheid has contributed significantly to the deterioration in traditional resource regulation and this in turn has led to the extensive resource degradation seen in parts of the country. Many of these assertions, though, remain anecdotal in nature. Given the high reliance by rural households on natural resources, and the serious negative implications that over-use has on livelihood security, understanding how well or poorly such commons are regulated is key to ensuring the sustainability of such resource-dependent populations. The aim of this study was therefore to examine systems of resource governance, focusing specifically on firewood, and to determine the roles of traditional and democratically elected community leaders in six rural villages spanning two chieftaincies in Bushbuckridge, South Africa. In each study village, five local leaders were interviewed and five community focus groups were conducted. Results indicate that most parties still regard the Chief as the ultimate authority for regulating firewood harvesting. However, overall firewood management appears weak, at best, across the region. Although some authors attribute this to community confusion over the roles of local leaders in a new democracy, we provide evidence that other socio-political factors, including political expediency, may be driving the increasingly relaxed implementation of these firewood management systems. With resource dependence remaining a vital contributor to livelihood security across the developing world and with many rural communities facing increasing strain under local resource depletion, these findings shed new light on the complex social dynamics underlying the widely reported weakening of traditional institutions in South Africa. In so doing, it offers insights into local firewood governance that can be used to combat these challenges and thereby reduce regional social and ecological vulnerability being experienced in communal landscapes across the region.
Agglomeration Behavior of Non-Metallic Particles on the Surface of Ca-Treated High-Carbon Liquid Steel: An In Situ Investigation
Authors: Tanaka Yasuhiro , Pahlevani Farshid , Sahajwalla Veena
Published: March 2018

The agglomeration behavior of non-metallic inclusion is a critical phenomenon that needs to be controlled as it has a direct relationship with the performance of produced steel. Although the agglomerates can be potential points for serious defects in every grade of steel, they are likely to be more serious in high-carbon steel due to the low ductility of these grades of steels as well as their usage in severe conditions. Confocal scanning laser microscopes (CSLM) have been used by different researchers to investigate the agglomeration behavior of non-metallic particles at the interface of liquid steel and Ar gas, in situ. In recent decades, the agglomeration of Al2O3 particle in and on the surface of low-carbon steel has been widely investigated. However, there are very few studies focussing on non-Al2O3 inclusions which are included in a Ca-treated high-carbon steel. In this study, the agglomeration behaviors of sulfide/sulfide and sulfide/oxide particles on the surface of liquid high-carbon steel have been investigated in detail using CSLM. Agglomerations on the liquid surface are governed by capillary forces similar to the Al2O3 particle but this study demonstrates that agglomeration forces among non-Al2O3 particles on the surface of re-melted high-carbon samples are lower than pure-Al2O3 on the surface of low-carbon steel. Despite this, they show similar or longer acting lengths than pure-Al2O3.
Effect of Carbon Content on the Microstructure and Mechanical Properties of NbC-Ni Based Cermets
Authors: Huang Shuigen , Baets Patrick , Sukumaran Jacob , Mohrbacher Hardy , Woydt Mathias , Vleugels Jozef
Published: March 2018

The aim of this work was to correlate the overall carbon content in NbC-Ni, NbC-Ni-VC and NbC-Ni-Mo starting powders with the resulting microstructure, hardness, and fracture toughness of Ni-bonded NbC cermets. A series of NbC-Ni, NbC-Ni-VC and NbC-Ni-Mo cermets with different carbon content were prepared by conventional liquid phase sintering for 1 h at 1420 °C in vacuum. Microstructural analysis of the fully densified cermets was performed by electron probe microanalysis (EPMA) to assess the effect of carbon and VC or Mo additions on the NbC grain growth and morphology. A decreased carbon content in the starting powder mixtures resulted in increased dissolution of Nb, V, and Mo in the Ni binder and a decreased C/Nb ratio in the NbC based carbide phase. The Vickers hardness (HV30) and Palmqvist indentation toughness were found to decrease significantly with an increasing carbon content in the Mo-free cermets, whereas an antagonistic correlation between hardness and toughness was obtained as a function of the Mo-content in Mo-modified NbC cermets. To obtain optimized mechanical properties, methods to control the total carbon content of NbC-Ni mixtures were proposed and the prepared cermets were investigated in detail.
Introduction: Methodical Aspects of Comparison
Authors: Freiberger Oliver
Published: March 2018

Much ink has been spilled over the significance, the risks and benefits, and even the very possibility of comparison in the study of religion, but few scholars have reflected on how comparison actually works. [...]
Research on Flow Field Perception Based on Artificial Lateral Line Sensor System
Authors: Liu Guijie , Wang Mengmeng , Wang Anyi , Wang Shirui , Yang Tingting , Malekian Reza , Li Zhixiong
Published: March 2018

In nature, the lateral line of fish is a peculiar and important organ for sensing the surrounding hydrodynamic environment, preying, escaping from predators and schooling. In this paper, by imitating the mechanism of fish lateral canal neuromasts, we developed an artificial lateral line system composed of micro-pressure sensors. Through hydrodynamic simulations, an optimized sensor structure was obtained and the pressure distribution models of the lateral surface were established in uniform flow and turbulent flow. Carrying out the corresponding underwater experiment, the validity of the numerical simulation method is verified by the comparison between the experimental data and the simulation results. In addition, a variety of effective research methods are proposed and validated for the flow velocity estimation and attitude perception in turbulent flow, respectively and the shape recognition of obstacles is realized by the neural network algorithm.
The Weight of Categories: Geographically Inscribed Otherness in Botkyrka Municipality, Sweden
Authors: Hu Beiyi
Published: March 2018

This paper asked a paradoxical question: why have immigrants to Sweden (particularly refugees) become geographically, economically, and symbolically segregated despite the putatively generous provisions of Sweden’s welfare state? I sought to understand how people and institutions perceived and deployed categories that created geographically inscribed “Otherness” through a year-long fieldwork in Botkyrka Municipality of the Greater Stockholm area. My analysis weaved together three models for explaining social segregation: the relational, the symbolic, and the spatial. I then augmented these models by taking into account the legal and bureaucratic frameworks that influence social exclusion, as well as historical factors of geographical exclusion. My study revealed how the Swedish government has, despite repeated attempts to integrate immigrant populations into the national identity, nonetheless continued to demarcate immigrant populations both symbolically and geographically, first through a long history of categorizing immigrants as “non-Swedes” (whether as “foreigner,” “immigrant,” or “people with a foreign background”), and through policies that have inadvertently separated the spaces in which immigrants are able to live. Finally, I concluded that the nation’s ethnocultural and Volk-centered definition of nationhood makes it almost impossible for immigrants to be integrated into the Swedish society and propose a shift of academic interests in three aspects.
Comparative study of antibacterial properties of polystyrene films with TiOx and Cu nanoparticles fabricated using cluster beam technique
Authors: Popok Vladimir N , Jeppesen Cesarino M , Fojan Peter , Kuzminova Anna , Hanuš Jan , Kylián Ondřej
Published: March 2018

Background: Antibacterial materials are of high importance for medicine, and for the production and conservation of food. Among these materials, polymer films with metal nanoparticles (NPs) are of considerable interest for many practical applications.

Results: The paper describes a novel approach for the formation of bactericidal polymer thin films (polystyrene in this case), produced by spin-coating, with Ti and Cu NPs deposited from cluster beams. Ti NPs are treated in three different ways in order to study different approaches for oxidation and, thus, efficiency in formation of the particles with semiconducting properties required for the catalytic formation of reactive oxygen species. Cu NPs are used as deposited. Partial NP embedding into polystyrene is realised in a controllable manner using thermal annealing in order to improve surface adhesion and make the particles resistant against wash-out. The formed composite films with TiOx and Cu species are tested as bactericidal media using E.coli bacteria as model microorganisms.

Conclusion: The obtained results show considerable efficiency in destroying the bacteria and a good possibility of multiple re-use of the same composite films making the suggested approach attractive for the cases requiring reusable polymer-based antibacterial media.