bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of Gross Up and Net Method in Tax Planning Order Study Case in PT. Sumber Citra Megah
Authors: Christian Tommy , Hardan Ahmaf Omar Nafi
Published: August 2023

A tax management system for the effective is the most important thing to stay in a current situation. There needs to be a tax planning in the work plan without having to violate prevailing tax law. Implementation planning income tax article 21 by the company expected to minimize employees tax cost, that will benefit both sides. This research using any objects PT. Sumber Citra Megah. Implementation planning income tax article 21 by the company is expected to to minimize the tax charges to be indebted issued employees, that automatically be able to maximize profit after tax. The result showed that PT. Sumber Citra Megah do not planning income tax article 21 optimally because the calculation of THR, the salary employees and the competitive salary survey. Based on the research, company must evaluate income tax article 21 planning optimally by did not violate tax provisions apply. In this case, the company should provide income tax allowances using the gross up method, and replace the provision of in-kind with allowances in the form of money that flow directly to employees, because that way these costs can increase the company's fiscal costs and on the side of the employees it is also profitable because their take home pay will increase.
Organizational Communication Strategy For Quick Public Response Service In Cilandak Sub-District, South Jakarta In Improving The Image
Authors: Saktisyahputra  , Sutanto Agung
Published: August 2023

This study was conducted to analyze the organizational communication strategy for the Quick Public Response (CRM) service in Cilandak Sub-District in improving the image. A communication strategy is an organizational plan to manage the strategy of the newly developed ideas, combined with the recipient of the message through the media, and achieve the effect of good communication goals. The data analysis technique used was descriptive qualitative analysis through observation and interviews. The sources of data were primary and secondary data. The field research data collection method was in the form of observation, interviews, and literature study. The interview technique was carried out in a structured manner. The resource persons in this study were 6 people, i.e., the Head of Cilandak Sub-district, Head of the Government Section of the Cilandak Sub-District Office, Communication Lecturer at the Stiami Institute of Social Sciences and Management, Service Staff of the Cilandak Sub-District Office, and the people of Cilandak Sub-District. From the results of this analysis, the organizational communication strategy of the CRM service in Cilandak District in improving the image has implemented research indicators in accordance with the objectives of the CRM service.
Doctor Adam Talib's Public Relations Strategy in Improving the Quality of Patient Service
Authors: Putri Anggun Kartika , Alzboon Mowafaq Salem
Published: August 2023

As time goes by, hospitals are now facing an era of global competition in various medical fields. The rapid development of science and technology in the medical field has created competition between hospitals. This increasingly fierce competition requires hospitals to provide the best service. This study aims to determine the public relations strategy in improving the quality of service at the Adam Talib Hospital. This research is qualitative. The data obtained using interview, observation, and documentation techniques. The results of this research are the strategies applied by public relations, namely: 1. One Rate Service, 2. Service Without Down Payment, 3. Employee Training, 4. Evaluation Meeting, 5. Customer Satisfaction Survey, 6. 24 Hour Laboratory Service, 7. Customer 24 Hours Service. The obstacles faced were: 1. Patients went home at their own request, 2. Covid 19, 3. High competition, 4. Negative testimonials, 5. Patients did not understand medical language. Then the efforts made are: 1. Collaborating with Kitabisa, 2. Promoting on Social Media, 3. Implementing Health Protocols, 4. Using language that is easy for patients to understand. There is a strategy that is applied in addition to creating a good image of the Adam Talib Hospital but also to increase the number of new customers, increase patient trust, increase relationships with other parties, and increase customer loyalty.
Public Relations Marketing Strategy In Improving Product Brand Image Through Instagram (@Wings_indonesia)
Authors: Akbar Adam Ali , Umer Saiyed
Published: August 2023

PT Sayap Mas Utama (Wings Group) 'Wings' has become a large company that exports its products worldwide since its establishment 60 years ago in East Java and is engaged in retail. In this study, the author uses Instagram and its features that exist for the implementation of Marketing Public Relations of Product Wings in making strategies to improve brand image at PT Sayap Mas Utama (Wings Group). The approach with consumers is carried out qualitatively. This type of research uses qualitative methods with in-depth interview techniques. The results of research conducted by researchers show that Wings is still lacking in promotions using Instagram, especially promotions in introducing Wings products because the content posted on Instagram shows more only for the celebrating of religious holidays, or national holidays. Meanwhile, Instagram can have a big impact on improving the brand image of the Wings Group.
Analysis of Factors Affecting Tobacco Export Volumes di Central Java Province Year 2010-2021
Authors: Nurcahyani Weni , Sharma Abhishek
Published: August 2023

This study discusses the price of tobacco and tobacco production on the volume of tobacco exports in Central Java Province in 2010-2021. This study aims to determine the effect of tobacco prices and tobacco production on the volume of tobacco exports in Central Java Province in 2010-2021. This research is aquantitative research with the subject of this research is Central Java Province. The data used comes from the Central Java Province Statistics Center in 2010-2021. The data analysis method used is a multiple linear regression analysis model using the EViews 12 program. The results of this study indicate that there is a positive and significant effect of tobacco production on the volume of tobacco exports in Central Java Province, and there is a negative and insignificant effect of tobacco prices on export volumes. tobacco in Central Java Province. And there is a positive and significant effect of price and production on the volume of tobacco exports in Central Java Province.
Analysis of the layout of the Dangerous and Toxic Goods (B3) warehouse using the 5S method (Seiri, Seiton, Seiso, Seiketsu, and Shitsuke) on PT Mitra Agung Sejati
Authors: Marnova Bonji , Tung Tran Minh
Published: August 2023

This research was conducted at PT Mitra Agung Sejati. The purpose of this study is to analyze the  layout of dangerous and toxic goods (B3) warehouses using the 5s method (Seiri, Seiton, Seiso, Seiketsu, and Shitsuke) at PT Mitra Agung Sejati. The research methodology used in this study is qualitative research method. The results of the study explained that this B3 storage area has not met the 5S principle, namely the absence of sorting, neat and clean arrangement for hazardous and toxic materials and labeling goods. The actual layout of this company is not organized, making operators uncomfortable in picking and storing hazardous and toxic materials to be used or quantities to be stored. However, after being researched and proposed using the 5S method, activities in the warehouse will be more organized and operators will find it easier to pick up goods and store goods such as labeling and making markings for the location of goods and laying work tools and marking for forklift parking. Through the application of this 5S method, the physical condition of the work environment at PT. Mitra Agung Sejati is more neatly organized and affects the comfort of workers.
Analysis of Internal and External Factors of Transport Delay in PT Sari Dumai Oleo
Authors: Butar Prima Alexander , Ahmed Abdussalam Ali
Published: August 2023

This research was conducted at PT Sari Dumai Oleo. The purpose  of this study is to analyze Internal and External Factors of Transportation Delay at PT Sari Dumai Oleo. In this study, researchers distributed 20 questionnaires to  respondents, and these respondents were directly related to the object of research. The research methodology used in this study is quantitative research method. Based on the results of data analysis and discussion of the results of research data analysis on the influence of internal and external factors on transportation delays, it can be concluded that the results of the study show a positive and significant influence between internal and external factor variables on transportation delay variables. Based on descriptive research variables, internal and external variable factors have a grand mean value of 4.11 which is categorized at Good level and transportation delay variable has a grand mean value of 3.80 which is categorized at Good level. Internal and external variables can explain or explain the variable of transportation delay by 56.4% and the remaining 43.6% is influenced by factors that are not included in this study. Based on the results of the t test, the t-count value was obtained > t-table (6.022 > 2.048) with a significance level of 0.000 < 0.050. This means that H1 is accepted and H0 is rejected. It partially shows that internal and external factors have a significant effect on transportation delays.
Problems and Prospects of Interaction between Subjects of Public and State Control in the Russian Federation
Authors: Goncharov Vitalii Viktorovich
Published: August 2023

Coverage of the problem. This article is devoted to the analysis of problems and prospects of interaction of subjects of public and state control in the Russian Federation. The relevance of this topic is due to the fact that the effectiveness and efficiency of the institute of public control largely depends on the level of interaction of the above-mentioned subjects. Materials and methods of research. The subject of the analysis is the relevant provisions of Russian legislation devoted to the consolidation of the mechanism of interaction between subjects of public and state control and the practice of their application in our country. The article uses general and private scientific methods, in particular: dialectical, logical, functional, formal-legal, comparative-legal, etc. Results. The article develops and substantiates a system of measures to resolve them, including by making appropriate amendments and additions both to the legislation on public control and to regulatory legal acts regulating the organization and activities of subjects of state control. This will allow, on the one hand, to carry out further development of the institution of public control, and on the other hand, to increase the efficiency of interaction of their subjects with state control bodies. Discussion. The issues of developing and introducing new forms and methods of interaction between subjects of public and state control in Russia need further scientific understanding.
On the Issue of Forming a System of Strategic Planning Documents as Management Acts
Authors: Ishchenko Alexander Alekseevich
Published: August 2023

In the process of implementing public administration, the implementation of the provisions of the current legislation on strategic planning has an essential role and significance. Effective provision of the latter makes it possible to achieve short-term, medium-term, long-term goals and objectives formed at the state, regional and municipal levels. The subject of this study is strategic planning documents in the context of their application as management acts. The purpose of the work was to conduct a study of the features of strategic planning documents as management acts, identify existing problems in the array of strategic planning documents, as well as identify priority areas for improving the mechanism of legal regulation of strategic planning in the Russian Federation. To achieve the goal, the provisions of the current legislation and the positions that have developed in the legal doctrine with the use of general and special methods of scientific research are considered. A comprehensive analysis of existing approaches allowed us to draw a number of conclusions regarding the legal nature of strategic planning documents as acts of public administration, to identify a number of characteristic features for them. Proposals are formulated regarding the place of strategic planning documents in the system of public administration acts and the prospect of further development of legislation on strategic planning, as well as priority areas for further scientific research of this legal phenomenon. The data obtained can be used in the process of theoretical understanding of topical issues of strategic planning and practical activities to improve legal regulation in terms of the application of strategic planning documents.
Reception of Soviet painting in the art of mainland China in the first half of the 20th century
Authors: Bai Jie
Published: August 2023

The realist ideas and revolutionary concepts characteristic of Russian oil painting were of special significance for the development of art in China in the 20th century. In particular, in the 1950s, the leaders of the Chinese Communist Party praised and promoted Russian and Soviet painting at the state level, which greatly contributed to the formation of the idea of realist painting and the scientific system of teaching oil painting in Chinese society. This paper examines the core values of socialism embodied in Russian oil painting and their derivatives; traces the development of oil painting in China; records the significant role of socialist features in the development of oil painting from different perspectives; and explains the influence of the Soviet art education system on the development of oil painting in China. This paper comprehensively examines the positive impact of Soviet painting on the development of Chinese art education, which contributed to the development of modern Chinese art in terms of artistic creativity, artistic organization and the construction of a system of art education.
Comments on S.G.Semenova's introductory article "Russian Cosmism" (changing the optics of comprehension)
Authors: Rozin Vadim Markovich
Published: August 2023

The article discusses two main topics: Russian cosmism and the attitude towards it of Svetlana Semenova, who wrote the introductory article to the book "Russian Cosmism". Interesting considerations are given regarding the Russian cosmism of the philosopher A.P. Ogurtsov. The author problematizes the statements of Semenova, who distances herself from the views of cosmists and shares these views. He sees a similar ambivalent attitude in the polemic of I. Kant with the great scientist and esotericist of the XVIII century Emanuel Swedenborg. An analysis of the esoteric Christian teaching and the personality of the latter shows that Swedenborg simultaneously accepted two realities of spirit and nature, removing contradictions, bringing them into line with each other; at the same time, his psyche changed under the influence of work confirming the new picture of the world he had built. The author suggests that, like Swedenborg, cosmists and Semenova built a reality in which their dreams, intentions and actions received a place and meaning.   He believes that in order to properly understand this type of creativity, a turn is needed to the problems and aspirations of the individual, to the built reality in which these problems are resolved (albeit in virtual terms for now), to the historical tradition of thinking. In his opinion, cosmists, Semenova and some modern ideologists like A. Dugin or Yu. Gromyko continue to move in line with the Russian tradition, outlined by Chaadaev, Dostoevsky and Russian religious philosophers. Another tradition characteristic of the creativity of these thinkers is esoteric, which allows you to create realities, omitting the problems of realization, following one ‒ constructing the world for your own personality.
The theme of the family in Soviet and Chinese woodcuts of the 1930s-1950s.
Authors: Wu Guanwen
Published: August 2023

The article examines the features of the image of the family theme in the woodcuts of China and the USSR of the 1930s-1950s. The subject of the study are Soviet and Chinese woodcuts of the 1930s-1950s. The focus is on the analysis of the processes of interaction and mutual influence of graphic art of the two countries, special attention is paid to the study of expressive means and techniques used by artists to convey images of people within the family theme. The reasons for the appeal of the masters of engraving of the time under consideration to the theme of family, the embodiment of eternal universal values in the works, which became a common feature and trend of graphic art of the two countries in the middle of the twentieth century, are revealed. The scientific novelty lies in the introduction into scientific circulation and analysis of the works of woodcut of Russia and China, the identification of common and different features in the subject of Chinese woodcut and Soviet engravings of the 1930s-1950s. The study shows and substantiates the significant influence of Soviet realistic art on the work of Chinese masters, reveals the patterns of development of Chinese woodcut art in the period under review. In conclusion, the gradual appeal of Chinese artists to their own national heritage and the strengthening of the national identity of Chinese art in the middle of the twentieth century is noted, the causes of these processes in the artistic life of the country are revealed.
NATURE-BASED DESIGN APPROACHES IN INTERIOR DESIGN: AN INCLUSIVE DESIGN FRAMEWORK SUGGESTION
Authors: YASAR Dilek
Published: August 2023

Doğa her daim, mimari tasarım için önemli bir ilham kaynağı olmuştur. Doğayı gözlemleyen mimarlar kimi zaman doğada var olanı taklit ederek kimi zaman ondan esinlenerek tasarımlarına yön vermişlerdir. Ancak son on yıllarda artan küresel iklim krizi ve doğal çevreye yönelik sorunlar ve yanı sıra insanların doğayla olan bağlarının zayıflaması sebebi mimarlar, insan ve doğa ilişkisini farklı bir boyutta ele almaya başlamışlardır. Bu anlamda mimarlar, doğa ve insan iletişimini esas alan; çevresel kaynakları korurken insan sağlığını ve refahını da göz önünde bulunduran ve ayrAıca tasarımın kültürel yönlerini de dikkate alan doğa temelli tasarım yaklaşımları ortaya koymuşlardır. Sürdürülebilirliğin önem kazandığı, doğa, kültür ve insan ilişkilerinin yeniden ve farklı biçimlerde sıklıkla gündeme geldiği günümüzde, insan sağlığı, esenliği ve refahında önemli bir yer tutan bu yaklaşımlar daha sağlıklı, konforlu ve çevre dostu iç mekanların tasarımında son derece önemlidir. Bu noktadan hareketle çalışmada, akademik çevrelerce kabul görmüş olan yeşil tasarım, ekolojik tasarım ve biyofilik tasarım olmak üzere üç doğa temelli tasarım yaklaşımına odaklanılmış ve bu yaklaşımların benzerlik ve farklılıklarından yola çıkılarak, sürdürülebilir ve kapsayıcı bir iç mekân tasarım çerçevesi sunulmuştur. Bu doğrultuda nitel araştırma yöntemlerinden biri olan ve tümevarımsal bir sürece dayalı olarak işleyen gömülü teori metodu uygulanmış ve bu bağlamda ilk olarak bu tasarım yaklaşımları ve ilkeleri derin literatür taraması yoluyla açıklanmıştır. Ardından bu tasarım yaklaşımlarının benzerlik ve farkları temel alınarak iç mekân tasarımına yönelik kapsayıcı bir tasarım çerçevesi önerisinde bulunulmuştur. Çalışma, doğa temelli, sürdürülebilir özelliklere sahip iç mekân tasarım yaklaşımlarının hem iç mimarlar hem de kullanıcılar için sunduğu potansiyelleri vurgulaması bakımından önemlidir. Çalışmanın sürdürülebilir tasarım yaklaşımları ile ilgilenen iç mimarlara yeni bir bakış açısı sunacağı ve yanı sıra ilgili literatüre katkı sağlayacağı düşünülmektedir.
Czas wolny - o codziennych i niecodziennych scenariuszach do�wiadczania
Authors: Mroczkowska Dorota Irena
Published: August 2023

Przedstawianie czasu wolnego jako czasu poza prac� nie oddaje w pe�ni wsp�czesnej rzeczywisto�ci, gdzie czas pracy i czas wolny na skutek m.in. elastycznego czasu pracy czy obecno�ci technologii mobilnych ulegaj� zacieraniu. Dodatkowo coraz cz�ciej mamy do czynienia z sytuacjami, kiedy jednostki wykonuj� r�wnocze�nie dwie i wi�cej aktywno�ci (ang. multitasking) czy z tymi wskazuj�cymi na wielowymiarowo�� praktykowania czasu wolnego (ang. multi-dimensional nature of leisure). Tym samym w badaniu czasu wolnego niemo�liwe s� do utrzymania tradycyjne metodologie ilo�ciowe oparte na dychotomii praca - czas wolny. Tekst prezentuje do�wiadczeniow� perspektyw� podej�cia do problematyki czasu wolnego opart� na metodologii interpretatywnej i triangulacji metod badawczych. Efektem takiego podej�cia jest perspektywa my�lenia o czasie wolnym, kt�ra zrywa z tradycyjn� dychotomi� praca - czas wolny na rzecz subiektywnego do�wiadczania, kt�rego wynikiem jest r�norodno�� form, styl�w i sposob�w sp�dzania czasu wolnego w zmiennym kontek�cie spo�ecznym.
Kilka uwag o pandemicznej t�sknocie Polak�w za turystyk� festiwalow�
Authors: Parus-Jankowska Magdalena
Published: August 2023

Pandemia Covid-19 znacz�co zmieni�a formy sp�dzania czasu wolnego, mi�dzy innymi wp�yn�a na spos�b s�uchania muzyki - jednej z najcz�stszych aktywno�ci Polak�w w czasie wolnym. W pocz�tkowym okresie pandemii zamkni�to instytucje kultury, w tym te muzyczne, i odwo�ano koncerty plenerowe oraz festiwale, przez co s�uchacze stracili mo�liwo�� bezpo�redniego uczestniczenia we wszelkich wydarzeniach muzycznych, a arty�ci wykonywania muzyki na �ywo. Zar�wno jednym jak i drugim nie pozosta�o nic innego, jak przenie�� swoje aktywno�ci do Internetu. Szybko jednak okaza�o si�, �e takie obcowanie z muzyk� jest dla s�uchaczy (i wykonawc�w) niewystarczaj�ce. Z bada� wynika, �e jedn� z najwi�kszych t�sknot w czasie pandemii by�a ch�� uczestnictwa w wydarzeniu muzycznym na �ywo - koncercie lub festiwalu. Artyku� przedstawia festiwal jako przyk�ad wielozmys�owej kultury iwentu, rodzaju �wi�ta, w kt�rym muzyka odgrywa wa�ne spo�eczne funkcje - integracji spo�ecznej i budowania poczucia wsp�lnoty, czyli tego, czego Polakom w pandemii najbardziej brakowa�o.
Od �czasu wolnego� do �czasu niewolnego�? Dylematy spo�ecze�stwa osi�gni��
Authors: Grotowska Stella , Sroczy�ska Maria
Published: August 2023

Czas wolny nie nale�y do temat�w cz�sto podejmowanych przez socjolog�w w Polsce, mimo �e pozostaje do�wiadczeniem prawie ka�dego z nas, kto �yje w p�ynnej nowoczesno�ci. Problematyka ta obejmuje zakres niezwykle szeroki, nie spos�b jej uj��, ani tym bardziej zamkn��, w niewielkim tomie. Uwa�amy jednak, �e kategori� czasu wolnego warto podda� analizie, zw�aszcza �e niedawne prze�ycie pandemii COVID-19 zmieni�o nasz� codzienno��, tak�e w wymiarze czasu wolnego. By� mo�e rodz�ce si� przy tej okazji pytania mog� przekszta�ci� si� w pytania badawcze i zaowocowa� kolejnymi studiami.
Pu�apka czy dobrodziejstwo immersyjno�ci w bieganiu d�ugodystansowym? Czas wolny aktywnie wype�niany
Authors: Pr�fer Pawe� Edward
Published: August 2023

Artyku� opisuje, wyja�nia i interpretuje fenomen biegania d�ugodystansowego przez pryzmat kategorii immersyjno�ci. Poj�cie to w naukach spo�ecznych, tak�e w socjologii, raczej nie wyst�puje. Dlatego podj�to pr�b� jego operacjonalizacji. W analizie zastosowano kwerend� materia��w po�wi�conych zjawisku biegania, zamieszczanych g��wnie na w�oskich i polskich portalach internetowych. Zastosowano metod� opisu interpretacji dyskurs�w i tre�ci zawartych w mottach po�wi�conych bieganiu. Uwzgl�dniono przede wszystkim teori� relacyjno�ci oraz tez� o ulokowaniu jednostki w przestrzeni dw�ch mechanizm�w spo�ecznych: determinizmu oraz indywidualnej sprawczo�ci podmiotowej. Opracowano i zaktualizowano problem zar�wno w jego konkretnych przypadkach (narracje i prze�ycia biegaczy, osobiste do�wiadczenia autora w odniesieniu do zjawiska biegania, wznios�e i zdystansowane opinie na temat biegania), jak i w zasi�gu uniwersalnym (opisy i interpretacje pojawiaj�ce si� w badaniach po�wi�conych bieganiu d�ugodystansowemu). Na podstawie przeprowadzonych analiz wywnioskowano, �e fenomen biegania jest w przypadku biegaczy zar�wno wyzwalaj�cy, rekonstruuj�cy ich biografie, jak i immersyjny, to znaczy poch�aniaj�cy, �zniewalaj�cy�.
CD8+ tissue-resident memory T cells induce oral lichen planus erosion via cytokine network
Authors: Qing Maofeng , Yang Dan , Shang Qianhui , Peng Jiakuan , Deng Jiaxin , Lu Jiang , Li Jing , Dan HongXia , Zhou Yu , Xu Hao , Chen Qianming
Published: August 2023

CD8+ tissue-resident memory T (CD8+ Trm) cells play key roles in many immune-inflammation-related diseases. However, their characteristics in the pathological process of oral lichen planus (OLP) remains unclear. Therefore, we investigated the function of CD8+ Trm cells in the process of OLP. By using single-cell RNA sequencing profiling and spatial transcriptomics, we revealed that CD8+ Trm cells were predominantly located in the lamina propria adjacent to the basement membrane and were significantly increased in patients with erosive oral lichen planus (EOLP) compared to those with non-erosive oral lichen planus (NEOLP). Furthermore, these cells displayed enhanced cytokine production, including IFN-γ (Interferon-gamma, a pro-inflammatory signaling molecule), TNF-α (Tumor Necrosis Factor-alpha, a cytokine regulating inflammation), and IL-17 (Interleukin-17, a cytokine involved in immune response modulation), in patients with EOLP. And our clinical cohort of 1-year follow-up was also supported the above results in RNA level and protein level. In conclusion, our study provided a novel molecular mechanism for triggering OLP erosion by CD8+ Trm cells to secrete multiple cytokines, and new insight into the pathological development of OLP.
An open-source platform for head-fixed operant and consummatory behavior
Authors: Gordon-Fennell Adam , Barbakh Joumana M , Utley MacKenzie T , Singh Shreya , Bazzino Paula , Gowrishankar Raajaram , Bruchas Michael R , Roitman Mitchell F , Stuber Garret D
Published: August 2023

Head-fixed behavioral experiments in rodents permit unparalleled experimental control, precise measurement of behavior, and concurrent modulation and measurement of neural activity. Here, we present OHRBETS (Open-Source Head-fixed Rodent Behavioral Experimental Training System; pronounced ‘Orbitz’), a low-cost, open-source platform of hardware and software to flexibly pursue the neural basis of a variety of motivated behaviors. Head-fixed mice tested with OHRBETS displayed operant conditioning for caloric reward that replicates core behavioral phenotypes observed during freely moving conditions. OHRBETS also permits optogenetic intracranial self-stimulation under positive or negative operant conditioning procedures and real-time place preference behavior, like that observed in freely moving assays. In a multi-spout brief-access consumption task, mice displayed licking as a function of concentration of sucrose, quinine, and sodium chloride, with licking modulated by homeostatic or circadian influences. Finally, to highlight the functionality of OHRBETS, we measured mesolimbic dopamine signals during the multi-spout brief-access task that display strong correlations with relative solution value and magnitude of consumption. All designs, programs, and instructions are provided freely online. This customizable platform enables replicable operant and consummatory behaviors and can be incorporated with methods to perturb and record neural dynamics in vivo.
Toward an autism-friendly environment based on mobile apps user feedback analysis using deep learning and machine learning models
Authors: Haoues Mariem , Mokni Raouia
Published: August 2023

Autistic people are often disadvantaged in employment, education, etc. In fact, autistic students/employees face several challenges navigating and communicating with their superiors and colleagues. Mobile applications for people with Autism Spectrum Disorder (ASD apps for short) have been increasingly being adapted to help autistic people manage their conditions and daily activities. User feedback analysis is an effective method that can be used to improve ASD apps’ services. In this article, we investigate the usage of ASD apps to improve the quality of life for autistic students/employees based on user feedback analysis. For this purpose, we analyze user reviews suggested on highly ranked ASD apps for college students, and workers. A total of 97,051 reviews have been collected from 13 ASD apps available on Google Play and Apple App stores. The collected reviews have been classified into negative, positive, and neutral opinions. This analysis has been performed using machine learning and deep learning models. The best performances were provided by combining RNN and LSTM models with an accuracy of 96.58% and an AUC of 99.41%. Finally, we provide some recommendations to improve ASD apps to assist developers in upgrading the main services provided by their apps.
Review of intervention methods for language and communication disorders in children with autism spectrum disorders
Authors: Cui Mengmeng , Ni Qingbin , Wang Qian
Published: August 2023

In recent years, the number of patients—particularly children—with autism spectrum disorder (ASD) has been continually increasing. ASD affects a child’s language communication and social interaction to a certain extent and has an impact on behavior, intelligence level, and other aspects of the child. Data indicates that 40% to 70% of children with ASD experience language developmental delays, which are mainly manifested as lack of language or language developmental delay, self-talk, use of stereotyped language, parroting, et cetera. A language communication disorder is a major symptom of ASD and is the most common reason for patients to visit a doctor. Therefore, language intervention training and communication skills have been made a cornerstone of autism intervention. However, a literature search has revealed that most studies only examine certain intervention methods or a combination of two or three intervention methods, which cannot be used by therapists or rehabilitation teachers. Therefore, this article summarizes relevant literature on language communication training for ASD children at home and abroad and briefly introduces the characteristics and training methods of language disorders in children with ASD in order to provide some ideas and references for relevant researchers and practitioners.
BAG3 regulates bone marrow mesenchymal stem cell proliferation by targeting INTS7
Authors: Liu Yubo , Xu Renjie , Xu Jinfu , Wu Tiantian , Zhang Xiangxin
Published: August 2023

Background

BAG3 is an essential regulator of cell survival and has been investigated in the context of heart disease and cancer. Our previous study used immunoprecipitation-liquid chromatography-tandem mass spectrometry to show that BAG3 might directly interact with INTS7 and regulate bone marrow mesenchymal stem cell (BMMSCs) proliferation. However, whether BAG3 bound INTS7 directly and how it regulated BMMSCs expansion was unclear.

Methods

BAG3 expression was detected by quantitative real-time PCR in BMMSCs after siRNA-mediated BAG3 knockdown. BMMSC proliferation was determined using the CCK-8 and colony formation assays. The transwell migration, flow cytometry and TUNEL assays were performed to measure BMMSC migration, cell cycle and apoptosis, respectively. Moreover, co-immunoprecipitation, protein half-life assay and western blotting analyses were used to determine the regulatory mechanism underlying the BAG3-mediated increase in BMMSC proliferation.

Results

The results showed that knocking down BAG3 in BMMSCs markedly decreased their proliferative activity, colony formation and migratory capacity, and induced cell apoptosis as well as cell cycle arrest. Meanwhile, overexpression of BAG3 had the opposite effect. Bioinformatics and BAG3-INTS7 co-immunoprecipitation analyses revealed that BAG3 directly interacted with INTS7. Moreover, the downregulation of BAG3 inhibited the expression of INTS7 and promoted its ubiquitination. We also observed that BAG3 knockdown increased the levels of reactive oxygen species and the extent of DNA damage in BMMSCs. Notably, the upregulation of INTS7 or the addition of an antioxidant scavenger could rescue the BMMSC phenotype induced by BAG3 downregulation.

Conclusions

BAG3 directly interacts with INTS7 and promotes BMMSC expansion by reducing oxidative stress.
Constructing a prognostic tool for predicting the risk of non-adherence to antiplatelet therapy in discharged patients with coronary heart disease: a retrospective cohort study
Authors: Cao Jiaoyu , Zhang Lixiang , Zhou Xiaojuan
Published: August 2023

Objective

To investigate the incidence and influencing factors affecting the non-adherence behavior of patients with coronary heart disease (CHD) to antiplatelet therapy after discharge and to construct a personalized predictive tool.

Methods

In this retrospective cohort study, 289 patients with CHD who were admitted to the Department of Cardiology of The First Affiliated Hospital of the University of Science and Technology of China between June 2021 and September 2021 were enrolled. The clinical data of all patients were retrospectively collected from the hospital information system, and patients were followed up for 1 year after discharge to evaluate their adherence level to antiplatelet therapy, analyze their present situation and influencing factors for post-discharge adherence to antiplatelet therapy, and construct a nomogram model to predict the risk of non-adherence.

Results

Based on the adherence level to antiplatelet therapy within 1 year after discharge, the patients were divided into the adherence (n = 216) and non-adherence (n = 73) groups. Univariate analysis revealed statistically significant differences between the two groups in terms of variable distribution, including age, education level, medical payment method, number of combined risk factors, percutaneous coronary intervention, duration of antiplatelet medication, types of drugs taken at discharge, and CHD type (P < 0.05). Furthermore, multivariate logistic regression analysis revealed that, except for the medical payment method, all the seven abovementioned variables were independent risk factors for non-adherence to antiplatelet therapy (P < 0.05). The areas under the receiver operating characteristic curve before and after the internal validation of the predictive tool based on the seven independent risk factors and the nomogram were 0.899 (95% confidence interval [CI]: 0.858–0.941) and 0.89 (95% CI: 0.847–0.933), respectively; this indicates that the tool has good discrimination ability. The calibration curve and Hosmer–Lemeshow goodness of fit test revealed that the tool exhibited good calibration and prediction consistency (χ2 = 5.17, P = 0.739).

Conclusion

In this retrospective cohort study, we investigated the incidence and influencing factors affecting the non-adherence behavior of patients with CHD after discharge to antiplatelet therapy. For this, we constructed a personalized predictive tool based on seven independent risk factors affecting non-adherence behavior. The predictive tool exhibited good discrimination ability, calibration, and clinical applicability. Overall, our constructed tool is useful for predicting the risk of non-adherence behavior to antiplatelet therapy in discharged patients with CHD and can be used in personalized intervention strategies to improve patient outcomes.
Clinical Profile, Comorbidities, and Outcome of the Unvaccinated and Hospitalized for COVID-19 in Northern Brazil: Retrospective Cohort
Authors: Ferreira Ana Lúcia Da Silva , Sardinha Daniele Melo , Moraes Daiane Cristina Viana De , Oliveira Maria Raimunda Rodrigues De , Viana Mayara Carolina Frazão , Andrade Natasha Cristina Oliveira , Soares Tamires De Nazaré , Guimarães Ricardo José De Paula Souza E. , Lima Luana Nepomuceno Gondim Costa , Lima Karla Valéria Batista
Published: August 2023

Introduction: Over the course of the pandemic, COVID-19 affected health, the economy and quality of life in Brazil. The worst years for the country were the first and second. There were delays in vaccine purchases for political reasons at the time. The northern region of the country had a higher mortality rate compared to other regions, associated with local vulnerabilities and fragility of surveillance due to geographic and population characteristics.

Objective: To investigate the clinical profile, comorbidities, and outcome of unvaccinated people hospitalized for COVID-19 in the state of Pará in 2022.

Methods: Retrospective cohort epidemiological study, with data from the national epidemiological surveillance of acute and severe respiratory syndromes. Cases reported in 2022 with vaccinated yes or no field and completed doses were included. Only closed cases cure or death were included. We performed a chi-square test on categorical variables and a Mann-Whitney test on numerical variables. We compared vaccinated VS non-vaccinated; we performed the Odds Ratio in the significant variables. We used the SPSS 20.0 software.

Results: The study worked with 2,634 cases of COVID-19 hospitalized in the study period, confirmed by RT-PCR (851/32.30%) and (1,784/67.70%) rapid antigen test. The lethality was (778/29.53%), and those vaccinated with two doses were (1,473/55.90%) and those unvaccinated with no dose (1,162/44.10%). Death represents p- <0.001 (HR 1.306 - CI 1.124/1.517) higher risk of the event occurring in the unvaccinated cases, followed by male sex p-0.004 (HR 1.188 - CI 1.058/1.334).

Conclusion: The first cohort in Brazil and in the north of the country to evaluate the clinical profile, comorbidities, and outcome of COVID-19 in hospitalized patients in this Amazon region, which is a region characterized by local vulnerability factors unique to the other regions of Brazil, showed that the unvaccinated were males, younger, with fewer comorbidities, and that they were associated the deaths.
Strengthening Coastal and Maritime Security of India in the Indian Ocean Region: An In-depth Analysis of the Challenges and Opportunities presented by Seabed Mining in India
Authors: Pandey Shivam Kumar
Published: August 2023

This research paper aims to provide a comprehensive analysis of India's coastal and maritime security in the Indian Ocean Region, specifically focusing on explicitly the challenges and opportunities associated with seabed mining in a kind of significant way. The legal framework governing seabed mining in India is primarily established by the “Mines and Minerals (Development and Regulation) Act, 1957 (MMDR Act)” in a considerable way. This act grants the central government the authority to regulate and control mining operations within India's territorial waters, exclusive economic zone, and continental shelf, which generally is reasonably significant. The paper highlights the challenges posed by seabed mining, including potential environmental impact, adherence to basically international agreements and conventions, and technological and operational challenges. It explores the importance of conducting environmental impact assessments (EIAs) and implementing mitigation measures to ensure sustainable mining practices in a big way. The steps taken to abide by the rules and regulations set by international organisations.
A Review of Building Community Resilience for Stress Free Future Farming
Authors: Sri B. Guru , Anand K. R. , Prakash D. , Lingireddy Hema , Gowtham K. V. , Akhil V. S. , Bhargava Kotte
Published: August 2023

Farming in India, despite numerous challenges, continues to play a pivotal role in feeding the nation's vast population. Recognizing the need for resilient agricultural practices to sustain the profession and secure the future of farming, explore the importance of adopting to change in the agricultural sector. The review highlights the current challenges faced by Indian agriculture, including climate change, diminishing natural resources, fragmented land holdings, lack of access to technology and information, and socio-economic disparities. These challenges pose significant threats to the sustainability and viability of farming, necessitating proactive measures to build resilience. To make farming stress-free and attractive for future generations, the review proposes various strategies and approaches that can enhance agricultural resilience. These include the adoption of climate-smart agricultural practices, such as conservation agriculture, precision farming, and agroforestry, to mitigate the adverse effects of climate change. Additionally, the promotion of sustainable water management techniques, efficient irrigation systems, and watershed management can address the issue of diminishing water resources. Recognizing the role of policy frameworks in fostering agricultural resilience, the paper underscores the need for government support in the form of favourable policies, subsidies, and incentives.
The Influence of Team Work and Spiritual Motivation on the Work Productivity of Volunteers of the Indonesian Sedekah Community Foundation
Authors: Ruwiyanto Ruwiyanto , Wiyarni Wiyarni
Published: August 2023

This study aims to examine the variables of team work and spiritual motivation on work productivity. The data for this study used primary data obtained from a sample of 78 Indonesian Sedekah Community Foundation volunteers spread across the Malang area, East Java, Indonesia. This data was collected through a questionnaire. There are seven indicators to measure team work. Those indicators are same goal, enthusiasm, clear roles and responsibilities, effective communication, conflict resolution, share power, and expertise. Spiritual motivation in this study is measured by faith motivation, worship motivation, and muamalat motivation. Work productivity is measure by 5 indicators (Quality of Work; Quantity; Timeliness; Effectiveness; and Independence). Data analysis was carried out using the SmartPLS software. This research shows that there is an influence on team work and spiritual motivation on the productivity of volunteer work.
The Effect of Ceramic Sales on the Performance of Ceramic Craftsmen with Digitalization as a Moderation Variable
Authors: Fatmawati Aprili Kurnia , Ana Riris Syifa , Setiani  , Muis Ahmad
Published: August 2023

Aims: This study aims to determine the effect of sales on the performance of ceramic craftsmen and also the moderating effect of digitalization on the effect of sales on performance.

Study Design: This research was conducted using a quantitative method, then the data obtained was analyzed using an explanatory research approach.

Place of Study: The target of this research is ceramic craftsmen in Malang City. The total population in this study is 30 ceramic craftsmen.

Methodology: The total population in this study is 30 ceramic craftsmen. Sampling was carried out using a saturated sampling technique, and it was found that the samples taken were 30 ceramic craftsmen. The process of collecting data with a distribution questionnaire. This study used SPSS 21 software. The questionnaires distributed were measured using a Likert scale.

Results: This study indicate that sales have a significant effect on performance. Furthermore, digitization has a significant effect on performance. Sales have a significant effect on digitization. Then there is an insignificant effect between sales on performance which is moderated by digitalization.

Conclusion: Utilization of digital technology can help ceramic craftsmen improve marketing strategies and increase the visibility of their ceramic products online, so as to increase sales. Digitization can also affect the way ceramicists manage their business, such as using more efficient inventory management or tracking systems, which in turn can improve overall performance.
Effects of Nitrogen Concentration on Growth, Yield and Phytochemical Content of Persicaria minor Cultivated Using Hydroponics System
Authors: Mohd Yaseer Suhaimi , Mirfat A. H. S. , Nurzahidah Z. A. Siti , Faris M. R. Muhammad
Published: August 2023

Persicaria minor or locally known as kesum from the family Polygonaceae is a common herbal plant found in Malaysia. Hydroponic cultivation of kesum using deep water culture (DWC) system can be an alternative option for kesum growers in increasing crop yields. The deep water culture system is a method in which liquid fertiliser solution is given directly to the plant roots without any medium and water flow. The study’s main objective was to determine the effects of nitrogen concentration on growth, yield and phytochemical content of kesum cultivated using hydroponic system. Plants were grown under one of four nitrogen concentration solution regimes and the experiment was conducted under a side netted rain shelter. The four treatments comprised of 200 mg/L, 100 mg/L, 50 mg/L and 0 mg/L of nitrogen concentrations. The experiment was arranged in Randomized Complete Block Design (RCBD) with 4 replications. Plants were selected randomly and harvested eight weeks after planting. Plants grown supplemented with 100 mg/L of nitrogen concentration gave the best growth performance and biomass yield. They produced the highest plant height (78 cm) and fresh biomass yield (174 g per plant). Meanwhile plants supplemented with 50 mg/L of nitrogen concentration produced the highest Quercetin-3-glucuronide (Q3G) (98.261 mg/mL) and Quercitrin (61.367 mg/mL) compound compared to the other treatments. However, plants treated with 0 mg/L of nitrogen concentrations exhibited major nutrients deficiencies symptoms and die after 3 weeks of planting. Hence, it can be concluded that the kesum plants cultivated using hydroponics’ deep water culture system supplemented with 100 mg/L of nitrogen concentration gave the highest plant growth and biomass yields. However, to obtain higher Quercetin-3-glucuronide and Quercitrin compound, 50 mg/L of nitrogen concentration is recommended.
Influences of Water Deficit Stress and Symbiosis with Growth-Promoting Bacteria on Seed Biochemistry of Camelina sativa
Authors: Borzoo Safoora , Mohsenzadeh Sasan , Kahrizi Danial
Published: August 2023

Camelina sativa, being a flowering plant in the family Brassicaceae, is traditionally cultivated as an oilseed crop due to its exceptionally high level (up to 45%) of omega-3 fatty acids, which is uncommon in vegetable sources. In the recent years camelina has been growing more than before because of its potentiality in the production of biodiesel and bioproduct. An aforementioned experiment was designed in three irrigation levels (100%, 75% and 50% of field capacity) and Micrococcus yunnanensis was used as plant growth-promoting bacteria during the reproductive phase.

The bacteria were incubated in a nutrient broth medium at the temperature of 28°C for 24h on shaker ceaselessly. When sowing, seeds were treated with 1.0 ml bacteria suspension in the inoculated groups. Water stress was applied to each pot in the levels of 75 and 50 % FC from the budding stage to full maturity in generative phase. Camelina silique yield was harvested at the maturity stage for analysis of seed quality and biochemical responses. Total soluble carbohydrate was extracted thrice from 100 mg of mature seed using extraction soluble including glacial acetic acid, methanol, and water. Oil and protein content were measured using Near-Infrared Reflectance spectrometer. Seed fatty acid contents were determined using gas chromatography. The results showed a significant relation between the highest proportion of fatty acid and the polyunsaturated fatty acid (55.12 to 65.66%) in particular linolenic acid. The increase of polyunsaturated fatty acid and saturated fatty acid was coincided with the decrease of monounsaturated fatty acid under water deficit stress. The application of plant growth-promoting bacteria is proven to increase protein with 50% of field capacity. In general, water deficit stress and plant growth-promoting bacteria have significant effects on the remobilization of nutrients from the soil to developing seed and following metabolism synthesis.