bluuebunny/crossref_metadata_2025 huggingface dataset:
Biologics in T2 Severe Asthma: Unveiling Different Effectiveness by Real-World Indirect Comparison
Authors: Riccardi Elisa , Guida Giuseppe , Garino Sonia , Bertolini Francesca , Carriero Vitina , Brusamento Mattia , Pizzimenti Stefano , Giannoccaro Fabiana , Falzone Erica , Arrigo Elisa , Levra Stefano , Ricciardolo Fabio Luigi Massimo
Published: August 2024

Background: Indirect comparison among biologics in severe asthma (SA) is a challenging but desirable goal for clinicians in real life. The aim of the study is to define characteristics of a biologic-treated T2-driven-SA population and to evaluate the effectiveness of biologic treatments in a real-world setting by variation in intra/inter-biologic parameters in an up to 4-year follow-up. Methods: Demographic, clinical, functional, and biological characteristics were evaluated retrospectively in 104 patients recruited until July 2022 at baseline (T0) and over a maximum of 4 years (T4) of biologic therapy (omalizumab/OmaG = 41, from T0 to T4, mepolizumab/MepoG = 26, from T0 to T4, benralizumab/BenraG = 18, from T0 to T2, and dupilumab/DupiG = 19, from T0 to T1). Variations of parameters using means of paired Delta were assessed. Results: At baseline, patients had high prevalence of T2-driven comorbidities, low asthma control test (ACT mean 17.65 ± 4.41), impaired pulmonary function (FEV1 65 ± 18 %pred), frequent exacerbations/year (AEs 3.5 ± 3), and OCS dependence (60%). DupiG had lower T2 biomarkers/comorbidities and AEs, and worse FEV1 (57 ± 19 %pred) compared to other biologics (p < 0.05). All biologics improved ACT, FEV1%, FVC%, AEs rate, and OCS use. FEV1% improved in MepoG and BenraG over the minimal clinically important difference and was sustained over 4 years in OmaG and MepoG. A significant RV reduction in OmaG (T4) and DupiG (T1), and BenraG normalization (T2) of airflow limitation were found. We observed through inter-biologic parameters pair delta variation comparison a significant nocturnal awakenings reduction in BenraG vs. OmaG/MepoG, and neutrophils reduction in BenraG/DupiG vs. OmaG. Conclusions: Indirect comparison among biologics unveils clinical and functional improvements that may mark a different effectiveness. These results may highlight the preference of a single biologic compared to another with regard to specific treatable traits.
The Musculoskeletal Pain Intensity and Interference Questionnaire for Musicians: Assessment of Patient-Related Outcomes among Professional Orchestra Musicians in Poland—A Cross-Sectional Study
Authors: Cygańska Anna Katarzyna , Kaczorowski Michał , Rodzik Beata
Published: August 2024

Background: Musculoskeletal pain is one of the reasons for a musician’s inability to play an instrument. An assessment of the localization, intensity, and interference of those complaints is important among musicians because of the risk of occupational disease. Assessment by validated tools is especially important and serves as an indicator to take up proper preventive or treatment actions. The aim of the study was to assess the prevalence of playing-related musculoskeletal disorders (PRMDs) and the relationships with PRMDs’ impact on playing musical instruments among Polish professional orchestra musicians. Methods: The study was conducted on a group of professional orchestra musicians (age 37.19 ± 9.62 years), 99 (55%) women and 83 (45%) men. Work experience in professional orchestra was 18.3 ± 9.83 years and the reported years of playing musical instrument were 31.4 ± 9.50. The study used the online version of a musician-dedicated questionnaire, Musculoskeletal Pain Intensity and Interference Questionnaire for Musicians of the Polish Population (MPIIQM-P). Results: In the study group, 89.9% of women and 83.1% of men had experienced playing-related pain in their lifetime. The most intense pain among the group with current playing-related musculoskeletal complaints (n = 85) was located in the neck area for 19 (22.4%). Conclusions: The results of the study indicate a high prevalence of playing-related musculoskeletal problems among professional musicians.
Long COVID Syndrome: A Narrative Review on Burden of Age and Vaccination
Authors: Finamore Panaiotis , Arena Elena , Lupoi Domenica , Savito Luisa , Di Nunzio Francesca , Furbatto Michela , Dragonieri Silvano , Antonelli Incalzi Raffaele , Scarlata Simone
Published: August 2024

Background/Objective: The COVID-19 pandemic has led to the emergence of post-acute COVID-19 syndrome, also known as long COVID, which presents a significant challenge due to its varied symptoms and unpredictable course, particularly in older adults. Similar to COVID-19 infections, factors such as age, pre-existing health conditions, and vaccination status may influence the occurrence and severity of long COVID. The objective is to analyze the role of aging in the context of long COVID and to investigate prevalence rates and vaccination efficacy to improve prevention strategies and treatment in this age group. Methods: Four researchers independently conducted a literature search of the PubMed database to trace studies published between July 2020 and July 2024. Results: Aging influences both the likelihood of developing long COVID and the recovery process, due to age-related physiological changes, immune system alterations, and the presence of comorbidities. Vaccination plays a key role in reducing the risk of long COVID by attenuating the inflammatory responses associated with its symptoms. Conclusions: Despite the protection vaccines offer against severe infection, hospitalization, and post-infection sequelae, vaccine hesitancy remains a major obstacle, worsening the impact of long COVID. Promising treatments for this condition include antivirals although further research is needed.
Therapeutic Management of Bronchiectasis in Children and Adolescents: A Concise Narrative Review
Authors: Faverio Paola , Franco Giovanni , Landoni Valentina , Nadalin Marta , Negri Davide , Tagliabue Alessandro , Acone Federica , Cattaneo Francesca , Cipolla Filippo , Vimercati Chiara , Aliberti Stefano , Biondi Andrea , Luppi Fabrizio
Published: August 2024

Introduction: Bronchiectasis, characterized by airway dilation, mucus hypersecretion, and recurrent exacerbations, is increasingly recognized in children and adolescents. Recent guidelines from the European Respiratory Society (ERS) and Thoracic Society of Australia and New Zealand (TSANZ) emphasize early diagnosis and optimized management. This review explores therapeutic strategies for pediatric bronchiectasis. Materials and methods: Our review involved a comprehensive search of English-language literature in the PubMed and EMBASE databases until December 2023, focusing on observational studies, interventions, reviews, and guidelines in pediatric bronchiectasis. Results: Management strategies encompass airway clearance techniques, mucoactive agents, pulmonary rehabilitation, bronchodilators and inhaled corticosteroids tailored to individual needs and age-appropriate techniques. Antibiotics play key roles in preventing exacerbations, eradicating pathogens, and managing acute exacerbations, which are guided by culture sensitivities and symptoms. Long-term antibiotic prophylaxis, particularly macrolides, aims to reduce exacerbations, although concerns about antibiotic resistance persist. Vaccinations, including pneumococcal and influenza vaccines, are crucial for preventing infections and complications. Surgery and lung transplantation are reserved to severe, refractory cases after failure of medical therapies. Conclusions: The optimal management of pediatric bronchiectasis requires a multidisciplinary approach, including physiotherapy, pharmacotherapy, and vaccinations, tailored to individual needs and guided by evidence-based guidelines. Further research is needed to refine diagnostic and therapeutic strategies and improve outcomes for affected children and adolescents.
Risk of Subsequent Hip Fractures across Varying Treatment Patterns for Index Vertebral Compression Fractures
Authors: Ton Andy , Bell Jennifer A. , Karakash William J. , Alter Thomas D. , Erdman Mary Kate , Kang Hyunwoo Paco , Mills Emily S. , Ragheb Jonathan Mina , Athari Mirbahador , Wang Jeffrey C. , Alluri Ram K. , Hah Raymond J.
Published: August 2024

Introduction: Vertebral compression fractures (VCFs) pose a considerable healthcare burden and are linked to elevated morbidity and mortality. Despite available anti-osteoporotic treatments (AOTs), guideline adherence is lacking. This study aims to evaluate subsequent hip fracture incidence after index VCF and to elucidate AOT prescribing patterns in VCF patients, further assessing the impact of surgical interventions on these patterns. Materials and Methods: Patients with index VCFs between 2010 and 2021 were identified using the PearlDiver database. Diagnostic and procedural data were recorded using International Classification of Diseases (ICD-9, ICD-10) and Current Procedural Terminology (CPT) codes. Patients under age 50 and follow-up <one year following index VCF were excluded. Patients were categorized based on whether they received AOT within one year, preceding and after index VCF, and were subsequently propensity-matched 1:3 based on age, sex, and Elixhauser Comorbidity Index (ECI) score to compare hip fracture incidence following index VCF. Sub-analysis was performed for operatively managed VCFs (kyphoplasty/vertebroplasty). Statistical tests included Chi-squared for categorical outcomes, and Kruskal–Wallis for continuous measures. Results: Of 637,701 patients, 72.6% were female. The overall subsequent hip fracture incidence was 2.6% at one year and 12.9% for all-time follow-up. Propensity-matched analysis indicated higher subsequent hip fracture rates in patients initiated on AOT post-index VCF (one year: 3.8% vs. 3.5%, p = 0.0013; all-time: 14.3% vs. 13.0%, p < 0.0001). Conclusions: The study reveals an unexpected increase in subsequent hip fractures among patients initiated on AOT post-index VCF, likely due to selection bias. These findings highlight the need for refined osteoporosis-management strategies to improve guideline adherence, thereby mitigating patient morbidity and mortality.
Changes in Circulating Adipokine Levels in COVID-19 Patients
Authors: Wikar Tomasz , Rubinkiewicz Mateusz , Stygar Dominika , Chełmecka Elżbieta , Popiela Urszula , Michał Wysocki , Tylec Piotr , Maziarz Barbara , Kukla Michał
Published: August 2024

Objective: The COVID-19 pandemic has posed significant global health challenges. Despite extensive research efforts, the inflammatory response triggered by SARS-CoV-2 remains to be further explored and understood. Our study aims to examine the changes in serum concentrations of pro-inflammatory adipokines—visfatin and leptin—in COVID-19 patients in relation to a healthy control group. Patients/Materials/Subjects and Methods: The study consisted of forty COVID-19 patients and twenty-four healthy patients in the control group. Two serum samples were collected: upon admission and on the seventh day of hospitalization. Concentrations of visfatin and leptin in the serum, alongside routine biochemical parameters, were measured using enzyme immunoassay or enzyme-linked immunosorbent assay kits. The Shapiro–Wilk test was used to assess normality. Differences between independent groups were compared using the Mann–Whitney U test and Kruskal–Wallis ANOVA. Correlations were evaluated with Spearman’s rank correlation coefficient. Results: Our findings revealed significantly lower visfatin levels in COVID-19 patients compared to the control group upon admission (4.29 ng/mL, (3.0–6.88 ng/mL) vs. 37.16 ng/mL (24.74–50.12 ng/mL), p < 0.001 for visfatin 1 and 52.05 ng/mL, (31.2–69.66 ng/mL) vs. 37.16 ng/mL (24.74–50.12 ng/mL), p = 0.048 for visfatin 2). The visfatin level of COVID-19 patients returned to the normal levels, established in the control group. However, there was no significant difference in leptin levels between the two groups (p = 0.270 for leptin 1 and p = 0.129 for leptin 2). There was a positive correlation between BMI and leptin concentration (r = 0.66 and p = 0.00). Moreover, it was discovered that COVID-19 independently reduces visfatin levels during the first day of illness. Conclusions: The results of our research suggest that the onset of COVID-19 infection is correlated to visfatin levels. Association with leptin levels remains inconclusive. Further research is imperative to elucidate the intricate role of visfatin and leptin in SARS-CoV-2 infection and their potential as biomarkers for COVID-19 severity and prognosis.
Cationic Serine-Based Gemini Surfactant:Monoolein Aggregates as Viable and Efficacious Agents for DNA Complexation and Compaction: A Cytotoxicity and Physicochemical Assessment
Authors: Oliveira Isabel S. , Silva Sandra G. , Gomes Andreia C. , Real Oliveira M. Elisabete C. D. , Vale M. Luísa C. do , Marques Eduardo F.
Published: August 2024

Cationic gemini surfactants have emerged as potential gene delivery agents as they can co-assemble with DNA due to a strong electrostatic association. Commonly, DNA complexation is enhanced by the inclusion of a helper lipid (HL), which also plays a key role in transfection efficiency. The formation of lipoplexes, used as non-viral vectors for transfection, through electrostatic and hydrophobic interactions is affected by various physicochemical parameters, such as cationic surfactant:HL molar ratio, (+/−) charge ratio, and the morphological structure of the lipoplexes. Herein, we investigated the DNA complexation ability of mixtures of serine-based gemini surfactants, (nSer)2N5, and monoolein (MO) as a helper lipid. The micelle-forming serine surfactants contain long lipophilic chains (12 to 18 C atoms) and a five CH2 spacer, both linked to the nitrogen atoms of the serine residues by amine linkages. The (nSer)2N5:MO aggregates are non-cytotoxic up to 35–90 µM, depending on surfactant and surfactant/MO mixing ratio, and in general, higher MO content and longer surfactant chain length tend to promote higher cell viability. All systems efficaciously complex DNA, but the (18Ser)2N5:MO one clearly stands as the best-performing one. Incorporating MO into the serine surfactant system affects the morphology and size distribution of the formed mixed aggregates. In the low concentration regime, gemini–MO systems aggregate in the form of vesicles, while at high concentrations the formation of a lamellar liquid crystalline phase is observed. This suggests that lipoplexes might share a similar bilayer-based structure.
RNA-Seq Analysis in Non-Small Cell Lung Cancer: What Is the Best Sample from Clinical Practice?
Authors: Nibid Lorenzo , Sabarese Giovanna , Andreotti Luca , Canalis Benedetta , Righi Daniela , Longo Filippo , Grazi Margherita , Crucitti Pierfilippo , Perrone Giuseppe
Published: August 2024

RNA-based next-generation sequencing (RNA-seq) represents the gold standard for detecting gene fusion in non-small cell lung cancer (NSCLC). Despite this, RNA instability makes the management of tissue samples extremely complex, resulting in a significant number of test failures with missing data or the need to switch to other techniques. In the present study, we analyzed pre-analytical variables in 140 tumor tissue samples from patients affected by NSCLC to detect features that increase the chances of successful RNA-seq. We found that the success rate of the analysis positively correlates with the RNA concentration and fragmentation index. Interestingly, small biopsies were more suitable samples than surgical specimens and cell blocks. Among surgical specimens, wedge resections demonstrated better results than lobectomy. Moreover, samples stored for less than 30 days (1 month) had a better chance of success than older samples. Defining the role of pre-analytical variables in RNA-seq allows the detection of more suitable samples for analysis and more effective planning of molecular-based diagnostic approaches in NSCLC.
Relationship between Depression and Physical Activity Frequency in Spanish People with Low, Medium, and High Pain Levels
Authors: Denche-Zamorano Ángel , Salas-Gómez Diana , Parraca Jose A. , Tomas-Carus Pablo , Adsuar José Carmelo , Barrios-Fernandez Sabina
Published: August 2024

Depression is a mental disorder that causes great discomfort, is associated with unhealthy lifestyle habits, and affects the quality of life. People with pain show high depressive symptoms and a prevalence of physical inactivity. This study aimed to analyse the associations between depression (self-reported depression, depression status, depressive symptoms, and depression types) and physical activity frequency (PAF) in leisure time in middle-aged and older people with different pain levels (low, medium, and severe) living in Spain. A cross-sectional study based on the European Health Survey data from Spain (2014–2020) was carried out, with a final sample of 13,686 people with pain. Associations between depression-related variables and PAF were studied at the three levels of pain, comparing the prevalence of depression as a function of PAF. Regression models were performed to assess adjusted risk factors for depression (self-reported depression and depression status). It was found that PAF was related to depression at all three pain levels. Inactive people at each pain level had higher depression prevalence (self-reported depression, depression status, depression symptoms, and depressive types). Physical inactivity emerged as a risk factor for depression, both for self-reported depression and for depression status. Thus, increased PAF could help prevent or reduce depression and depressive symptoms in people with pain.
Scandinavian Erratics in the Cultural Heritage Sites of Western Poland
Authors: Górska-Zabielska Maria
Published: August 2024

In north-western Poland, cultural and historical structures were erected using erratic boulders of Scandinavian origin. These structures have yet to be subjected to detailed analysis with the aim of determining their origin, type of erratic boulders and rock abundance of a given petrographic type. This topic has not been addressed by art historians in previous studies of similar structures. The objective of this paper is to present five illustrative examples of stone structures that are closely related to cultural heritage in north-western Poland. A comprehensive inventory of the stone material is presented, categorised according to petrographic types. This is accompanied by a guide to the erratics. Furthermore, this article addresses the principles of geoethics and the concept of sense of place, with the objective of fostering a sense of pride in cultural heritage among residents and viewers. The objective was to identify the current and potential future geosystem services that erratic boulders can provide at the aforementioned locations. The survey methods were non-intrusive and included a comprehensive analysis of the stone material at eye level. Furthermore, in addition to graphic and photographic archiving, the petrographic type of rock and the type of indicative erratics were identified in carefully designed test fields. The results were subjected to basic statistical calculations. The results obtained represent a new corpus of knowledge that can be employed in the sustainable development of the five regions through the utilisation of a tool such as geotourism. It is anticipated that the implementation of innovative initiatives aimed at fostering geoenvironmental awareness and providing educational benefits, such as disseminating knowledge about the petrography and history of the sites (including the evolution of stone workshops and techniques), the role of historic buildings in strengthening attachment to roots, and their promotion in the media and on the internet, will result in the attraction of a more diverse group of tourists with interests beyond the current tourist and recreational offerings.
Evaluating the Impact of Green Spaces on Urban Heat Reduction in Rajshahi, Bangladesh Using the InVEST Model
Authors: Rahman Md. Mostafizur , Hasan Jahid
Published: August 2024

Urban heat poses significant challenges in rapidly developing cities, particularly in countries like Bangladesh. This study investigates the cooling effects of urban green spaces in Rajshahi city, addressing a critical research gap in developing urban contexts. We examined the relationships among urban vegetation, heat mitigation, and temperature variables using the InVEST Urban Cooling Model and spatial analysis techniques. This study focused on three key relationships: Normalized Difference Vegetation Index (NDVI) and Heat Mitigation Index (HMI), HMI and Land Sur face Temperature (LST), and HMI and Air Temperature (AT). Analysis revealed a strong positive correlation between NDVI and HMI, indicating the effectiveness of vegetation in enhancing urban cooling. A robust inverse relationship between HMI and LST was observed (R2 = 0.78, r = −0.88), with every 0.1 unit increase in HMI corresponding to a 0.53 °C decrease in LST. The HMI−AT relationship showed an even stronger correlation (R2 = 0.84, r = −0.87), with each unit increase in HMI associated with a 2.80 °C decrease in air temperature. These findings quantify the significant role of urban green spaces in mitigating heat and provide valuable insights for urban planning in developing cities, underscoring the importance of integrating green infrastructure into urban-development strategies to combat urban heat and improve livability.
Management and Outcomes for Peritoneal Dialysis Patients Diagnosed with Abdominal Hernias
Authors: Iorga Cristian , Iorga Cristina Raluca , Andreiana Iuliana , Stancu Simona Hildegard , Bengulescu Iustinian , Strambu Victor
Published: August 2024

Background/Objectives: The success of peritoneal dialysis is highly dependent on the integrity of the abdominal wall. Therefore, routine examination and treatment of abdominal hernias can prevent peritoneal dialysis (PD) failure, discontinuation, and conversion to hemodialysis. In this present study, we present our examination protocol for patients proposed for PD and our attitude in treating parietal defects in patients on peritoneal dialysis. Objectives: highlight whether PD is a risk factor for the occurrence of ventral hernias, the relationship between associated pathologies and the occurrence of hernias and the need for an HD switch in the postoperative period. Methods: Between January 2016 and December 2022, a group of 133 patients proposed for insertion of a PD catheter were evaluated according to the protocol established by our hospital. Routine examination for the diagnosis of abdominal hernias and repair before starting the DP is part of the procedure. We included patients with a 3 year minimum follow-up after insertion and evaluated the incidence of parietal defects that appeared during PD treatment. Results: Nine patients were diagnosed and operated on for abdominal hernia before starting peritoneal dialysis and none of them had a recurrence of hernia during PD. Twelve patients were diagnosed with abdominal hernias during dialysis treatment (9% incidence) and the median length of time at which parietal defects occur during PD is 12.5 months [range 2–48]. Median BMI is 27.12 [range 22.3–31.24], with a female–male ratio of 2:1 Five patients were transferred to HD, three permanently and two patients temporarily. No patient abandoned PD treatment due to the presence of an abdominal parietal defect. Conclusions: Diagnosis of ventral hernias prior to the time of catheterization for PD leads to a decrease in the incidence of parietal defects during PD and is mandatory in patients who are candidates for PD. Open alloplastic surgical procedures are safe procedures with a low recurrence rate in PD patients. The postoperative continuation of PD is feasible but the decision is to be made by the multidisciplinary team and individualized for each patient.
Advancements in Trauma-Induced Acute Kidney Injury: Diagnostic and Therapeutic Innovations
Authors: Lassola Sergio , Cundari Francesco , Marini Giuseppe , Corradi Francesco , De Rosa Silvia
Published: August 2024

Acute kidney injury following trauma impacts patient recovery critically, necessitating an integrated approach to emergency care and nephrology. This review aims to provide a comprehensive understanding of trauma-induced nephropathy, highlighting recent advancements in pathophysiological insights, diagnostic techniques, and strategic interventions. Our key findings emphasize the role of biomarkers, like Neutrophil Gelatinase-Associated Lipocalin and Liver Fatty Acid-Binding Protein, and imaging techniques, such as contrast-enhanced ultrasound, in early AKI detection. Preventive strategies, including aggressive fluid resuscitation, avoidance of nephrotoxic agents, and hemodynamic optimization, are essential for mitigating AKI progression. Integrating these approaches into trauma care frameworks aims to enhance patient outcomes and set a foundation for future research and clinical improvements.
Synchronous Breast and Colorectal Malignant Tumors—A Systematic Review
Authors: Iorga Cristian , Iorga Cristina Raluca , Grigorescu Alexandru , Bengulescu Iustinian , Constantin Traian , Strambu Victor
Published: August 2024

The incidence of breast and colorectal cancers is well established in studies, but the synchronous occurrence of the two types of tumors is a rarity. In general, they are discovered during screening investigations following the diagnosis of an initial tumor. Objective: Our aim is to describe the main diagnostic and therapeutic challenges for synchronous breast and colorectal tumors. Materials and methods: We performed a systematic review of the literature for cases or case series, using established keywords (synchronous breast and colon tumor and synonyms) for the period of 1970–2023. Five reviewers independently screened the literature, extracted data, and assessed the quality of the included studies. The results were processed according to the PRISMA 2020 guidelines. Results: A total of 15 cases were included in the study, including 2 males (age 50 and 57) and 13 females (median age 60, with range from 40 to 79). In a vast majority of the cases, the diagnosis of synchronous tumor was prompted by the first tumor’s workup. The first diagnosed tumor was colorectal in nine cases and a breast tumor in six cases. The most common histopathological type of breast tumor was invasive ductal carcinoma, and the colon tumors were exclusively adenocarcinomas. All cases had a surgical indication for both breast and colorectal tumor, except one case, in which the breast tumor had multiple metastasis. In four cases, the surgery was performed concomitantly (colectomy and mastectomy). In three cases, surgery was initially carried out for the breast tumor, followed by colon surgery. Oncological treatment was indicated depending on the tumor stage. Conclusions: For the treatment of synchronous tumors, the Tumor Board (T.B) decision is mandatory and must be personalized for each patient. Developing new methods of treatment and investigation may play an important role in the future for understanding synchronous tumor development, incidence, and outcome.
Investigation of X-rays Beams Uniformity in Radiotherapeutic Tumor Treatment Procedure Using LuAG:Ce Crystal Detectors
Authors: Witkiewicz-Łukaszek Sandra , Winiecki Janusz , Michalska Paulina , Jakubowski Seweryn , Sidletskiy Oleg , Zorenko Yuriy
Published: August 2024

In this study, Ce3+-doped Lu3Al5O12 garnet (LuAG) crystal detectors, with a density of ρ = 6 g/cm3 and an effective atomic number Zeff = 62, are proposed as promising materials for radiotherapy applications. This type of detector demonstrates excellent uniformity of structural and optical properties, high thermoluminescence (TL) light yield, optimal position of main TL glow peaks at temperatures around 245–295 °C, and high radiation stability. The set of TL detectors made from LuAG:Ce single crystal was used to evaluate the uniformity of dose and energy spectra of X-ray radiation from a clinical accelerator with 6 MV and 15 MV beams at the Department of Medical Physics, Oncology Center in Bydgoszcz, Poland, and γ-rays from a 60Co source at the National Institute of Oncology in Warsaw. The LuAG:Ce crystal detectors demonstrated highly promising results for registering X-ray radiation from accelerators with both 6 MV and 15 MV electron beams, as well as γ-rays from a 60Co source with energies of 1.17 and 1.33 MeV.
Planar Micro-Supercapacitors with High Power Density Screen-Printed by Aqueous Graphene Conductive Ink
Authors: Wang Youchang , Zhang Xiaojing , Zhu Yuwei , Li Xiaolu , Shen Zhigang
Published: August 2024

Simple and scalable production of micro-supercapacitors (MSCs) is crucial to address the energy requirements of miniature electronics. Although significant advancements have been achieved in fabricating MSCs through solution-based printing techniques, the realization of high-performance MSCs remains a challenge. In this paper, graphene-based MSCs with a high power density were prepared through screen printing of aqueous conductive inks with appropriate rheological properties. High electrical conductivity (2.04 × 104 S∙m−1) and low equivalent series resistance (46.7 Ω) benefiting from the dense conductive network consisting of the mesoporous structure formed by graphene with carbon black dispersed as linkers, as well as the narrow finger width and interspace (200 µm) originating from the excellent printability, prompted the fully printed MSCs to deliver high capacitance (9.15 mF∙cm−2), energy density (1.30 µWh∙cm−2) and ultrahigh power density (89.9 mW∙cm−2). Notably, the resulting MSCs can effectively operate at scan rates up to 200 V∙s−1, which surpasses conventional supercapacitors by two orders of magnitude. In addition, the MSCs demonstrate excellent cycling stability (91.6% capacity retention and ~100% Coulombic efficiency after 10,000 cycles) and extraordinary mechanical properties (92.2% capacity retention after 5000 bending cycles), indicating their broad application prospects in flexible wearable/portable electronic systems.
Stabilization of δ-like Bi2O3 Phase at Room Temperature in Binary and Ternary Bismuthate Glass Systems with Al2O3, SiO2, GeO2, and B2O3
Authors: Vlasenko Viktoriia , Nowagiel Maciej , Wasiucionek Marek , Pietrzak Tomasz K.
Published: August 2024

Recently, it was shown that the nanocrystallization of Bi2O3 glasses with the addition of SiO2 and Al2O3 leads to the stabilization of the δ-like Bi2O3 phase at least down to room temperature, which is significantly below its stability range in bulk form. In this research, we investigated the properties of bismuthate glasses synthesized with various glass-forming agents such as SiO2, GeO2, B2O3, and Al2O3. It was demonstrated that vitrification of all these systems is possible using a standard melt quenching route. Furthermore, we investigated the crystallization processes in pristine glasses upon increasing the temperature and the thermal stability of arising phases using thermal analysis and high-temperature XRD in situ experiments. It was shown that it is possible to stabilize crystallites’ isostructures with δ-Bi2O3 embedded in a residual glassy matrix down to room temperature. The temperature range of the appearance of the δ-like phase strongly depended on the nominal composition of the glasses. We postulate that the confinement effect depends on the local properties of the residual glassy matrix and its ability to introduce sufficient force to stretch the structure of the δ-like Bi2O3 phase in the nanocrystallites.
Three-Layered Composite Scintillator Based on the Epitaxial Structures of YAG and LuAG Garnets Doped with Ce3+ and Sc3+ Impurities
Authors: Witkiewicz-Łukaszek Sandra , Gorbenko Vitalii , Zorenko Tetiana , Pejchal Jan , Mares Jiri A. , Kucerkova Romana , Beitlerova Alena , Nikl Martin , Sidletskiy Oleg , Winiecki Janusz , D’Ambrosio Carmelo , Zorenko Yuriy
Published: August 2024

In this study, we propose novel three-layer composite scintillators designed for the simultaneous detection of different ionizing radiation components. These scintillators are based on epitaxial structures of LuAG and YAG garnets, doped with Ce3+ and Sc3+ ions. Samples of these composite scintillators, containing YAG:Ce and LuAG:Ce single crystalline films with different thicknesses and LuAG:Sc single crystal substrates, were grown using the liquid phase epitaxy method from melt solutions based on PbO-B2O3 fluxes. The scintillation properties of the proposed composites, YAG:Ce film/LuAG:Sc film/LuAG:Ce crystal and YAG:Ce film/LuAG:Ce film/LuAG:Sc crystal, were investigated under excitation by radiation with α-particles from a 239Pu source, β-particles from 90Sr sources and γ-rays from a 137Cs source. Considering the properties of the mentioned composite scintillators, special attention was paid to the ability of simultaneous separation of the different components of mixed ionizing radiation containing the mentioned particles and quanta using scintillation decay kinetics. The differences in scintillation decay curves under α- and β-particle and γ-ray excitations were characterized using figure of merit (FOM) values at various scintillation decay intensity levels (1/e, 0.1, 0.05, 0.01).
Optimized Sulfonated Poly(Ether Ether Ketone) Membranes for In-House Produced Small-Sized Vanadium Redox Flow Battery Set-Up
Authors: Rizzuti Antonino , Dilonardo Elena , Cozzolino Gennaro , Matera Fabio , Carbone Alessandra , Musio Biagia , Mastrorilli Piero
Published: August 2024

The ionic exchange membranes represent a core component of redox flow batteries. Their features strongly affect the performance, durability, cost, and efficiency of these energy systems. Herein, the operating conditions of a lab-scale single-cell vanadium flow battery (VRFB) were optimized in terms of membrane physicochemical features and electrolyte composition, as a way to translate such conditions into a large-scale five-cell VRFB stack system. The effects of the sulfonation degree (SD) and the presence of a filler on the performances of sulfonated poly(ether ether ketone) (SPEEK) ion-selective membranes were investigated, using the commercial perfluorosulfonic-acid Nafion 115 membrane as a reference. Furthermore, the effect of a chloride-based electrolyte was evaluated by comparing it to the commonly used standard sulfuric acid electrolyte. Among the investigated membranes, the readily available SPEEK50-0 (SD = 50%; filler = 0%) resulted in it being permeable and selective to vanadium. Improved coulombic efficiency (93.4%) compared to that of Nafion 115 (88.9%) was achieved when SPEEK50-0, in combination with an optimized chloride-based electrolyte, was employed in a single-cell VRFB at a current density of 20 mA·cm−2. The optimized conditions were successfully applied for the construction of a five-cell VRFB stack system, exhibiting a satisfactory coulombic efficiency of 94.5%.
Enhanced Generative Adversarial Networks for Isa Furnace Matte Grade Prediction under Limited Data
Authors: Ma Huaibo , Li Zhuorui , Shu Bo , Yu Bin , Ma Jun
Published: August 2024

Due to the scarcity of modeling samples and the low prediction accuracy of the matte grade prediction model in the copper melting process, a new prediction method is proposed. This method is based on enhanced generative adversarial networks (EGANs) and random forests (RFs). Firstly, the maximum relevance minimum redundancy (MRMR) algorithm is utilized to screen the key influencing factors of matte grade and remove redundant information. Secondly, the GAN data augmentation model containing different activation functions is constructed. And, the generated data fusion criterion based on the root mean squared error (RMSE) and the coefficient of determination (R2) is designed, which can tap into the global character distributions of the copper melting data to improve the quality of the generated data. Finally, a matte grade prediction model based on RF is constructed, and the industrial data collected from the copper smelting process are used to verify the effectiveness of the model. The experimental results show that the proposed method can obtain high-quality generated data, and the prediction accuracy is better than other models. The R2 is improved by at least 2.68%, and other indicators such as RMSE, mean absolute error (MAE), and mean absolute percentage error (MAPE) are significantly improved.
Cooling Air Velocity on Iron Ore Pellet Performance Based on Experiments and Simulations
Authors: Ma Liming , Zhang Jianliang , Liu Zhengjian , Cai Qiuye , Hao Liangyuan , Lu Shaofeng , Jiang Huiqing , Wang Yaozu
Published: August 2024

During the pellet cooling process, cooling air velocity is crucial for optimizing the cooling rate, evaluating the utilization rate of cooling heat energy, and improving pellet performance. As the simulated cooling air velocity increased, the gas temperature at the cooling endpoint decreased from 87 °C to 51 °C, and the solid temperature decreased from 149 °C to 103 °C. The total enthalpy of the recovered gas initially reduced and then increased while the heat recovery rate gradually increased. During the experiment, the inhomogeneity of pellet quality gradually increased with the rise in cooling air velocity. The effect of cooling air velocity on pellet properties is primarily reflected in the formation of cracks and low-melting liquid phases (FeO and fayalite). As the cooling air velocity increases, the softening onset temperature of the pellet decreases significantly. The melting zone decreases from 193 °C to 105 °C, and the permeability of the adhesive zone increases.
Effect of Temperature and Strain on Bonding of Similar AA3105 Aluminum Alloys by the Roll Bonding Process
Authors: Carta Mauro , Buonadonna Pasquale , Reggiani Barbara , Donati Lorenzo , Aymerich Francesco , El Mehtedi Mohamad
Published: August 2024

Accumulative roll bonding (ARB) is a severe plastic deformation process that enables the production of materials with ultrafine microstructures and enhances the characteristics of the base material, particularly in metal matrix composites. The primary objective of this study is to experimentally investigate the bonding strength in AA3105 strips that underwent the roll bonding process, with a specific focus on examining the influence of temperature and reduction rate on bonding. Three temperature levels (200 °C, 300 °C, and 400 °C) and three thickness reduction levels (35%, 50%, and 65%) were considered. The T-peel test was carried out to assess the bonding quality. It was employed to determine the peak force required to separate the two bonded strips. Additionally, ANOVA analysis was performed to develop a regression equation for analyzing peak force. Optical microscopy was used to evaluate the interface bonding quality in the longitudinal section. The results indicate that the bonding strength increases with both temperature and percentage reduction.
Evolutions on Microstructure and Impact Toughness of G115 Steel after Long-Term Aging at 700 °C
Authors: Yu Jianming , Ma Shaohai , Liang Kui , Yan Kai , Yang Xisheng , Zhang Shuli
Published: August 2024

The microstructure and impact toughness evolution of G115 steel after long-term (ranging from 500 h to 10,000 h) aging at 700 °C were investigated in this study. The results showed that the microstructure of the G115 steel evolved from a finer-grained matrix with minor precipitates to a coarse-grained matrix with more precipitate with aging time, presenting a decrease in the local deformation degree in the matrix. The impact toughness of the steel decreased with aging time, presenting the largest decline at the initial aging times. The decrease in impact toughness was attributed to the coarsening of precipitates (M23C6 and Laves phase) in the steel matrix. The stable impact toughness during the whole aging process (from 500 h to 10,000 h) should be related to the comprehensive effects, including the precipitation of the Laves phase, the increase in high-angle grain boundaries, and the softening of the metal matrix.
Thiazole Functionalization of Thiosemicarbazone for Cu(II) Complexation: Moving toward Highly Efficient Anticancer Drugs with Promising Oral Bioavailability
Authors: Luo Song-Yu , Zeng Chun-Mei , Xu Ping , Ning Ye , Dong Meng-Lin , Zhang Wen-Hua , Yu Guangliang
Published: August 2024

In this work, we report the synthesis of a new thiosemicarbazone-based drug of N′-(di(pyridin-2-yl)methylene)-4-(thiazol-2-yl)piperazine-1-carbothiohydrazide (HL) featuring a thiazole spectator for efficient coordination with Cu(II) to give [CuCl(L)]2 (1) and [Cu(NO3)(L)]2 (2). Both 1 and 2 exhibit dimeric structures ascribed to the presence of di-2-pyridylketone moieties that demonstrate dual functions of chelation and intermolecular bridging. HL, 1, and 2 are highly toxic against hepatocellular carcinoma cell lines Hep-G2, PLC/PRF/5, and HuH-7 with half maximal inhibitory concentration (IC50) values as low as 3.26 nmol/mL (HL), 2.18 nmol/mL (1), and 2.54 × 10−5 nmol/mL (2) for PLC/PRF/5. While the free ligand HL may elicit its anticancer effect via the sequestration of bio-relevant metal ions (i.e., Fe3+ and Cu2+), 1 and 2 are also capable of generating cytotoxic reactive oxygen species (ROS) to inhibit cancer cell proliferation. Our preliminary pharmacokinetic studies revealed that oral administration (per os, PO) of HL has a significantly longer half-life t1/2 of 21.61 ± 9.4 h, nearly doubled as compared with that of the intravenous (i.v.) administration of 11.88 ± 1.66 h, certifying HL as an effective chemotherapeutic drug via PO administration.
Motivations for Using Dietary Supplements in Elite Ice Hockey—Controlling Weight and Enhancing Performance
Authors: Christensen Sofie , Gjelstad Astrid , Björnsdottir Ingunn , Lauritzen Fredrik
Published: August 2024

Background: Excessive or improper use of dietary supplements (DSs) by athletes may cause adverse effects, such as impaired performance or failing a doping test, making it important for athletes to mitigate risk and make well-informed choices when using supplements. Methods: This study used focus group interviews to examine the attitudes, motivations, and practices related to DSs among male elite ice hockey players. Results: The players used a wide range of products, ranging from vitamins to multi-ingredient pre-workout supplements. Consuming DSs was considered as a practical and convenient way to ingest sufficient calories to gain or maintain the body weight and muscle mass needed to meet the physical requirements of the sport. The athletes demonstrated a lenient and ignorant attitude when acquiring and using supplements, with a non-critical trust in the guidance provided to them by the coach or physician. Having completed basic anti-doping education in the form of an e-learning program did not appear to result in taking a more careful approach to using DSs. Conclusions: Through their DS practices, elite ice hockey players may put themselves at risk for anti-doping rule violations. A comprehensive approach is needed when aiming to prevent unintentional doping in this athlete cohort.
Effect of Mutant and Engineered High-Acetate-Producing Saccharomyces cerevisiae var. boulardii Strains in Dextran Sodium Sulphate-Induced Colitis
Authors: Deleu Sara , Jacobs Inge , Vazquez Castellanos Jorge F. , Verstockt Sare , Trindade de Carvalho Bruna , Subotić Ana , Verstockt Bram , Arnauts Kaline , Deprez Lowie , Vissers Eva , Lenfant Matthias , Vandermeulen Greet , De Hertogh Gert , Verbeke Kristin , Matteoli Gianluca , Huys Geert R. B. , Thevelein Johan M. , Raes Jeroen , Vermeire Séverine
Published: August 2024

Acetate-producing Saccharomyces cerevisiae var. boulardii strains could exert improved effects on ulcerative colitis, which here, was preclinically evaluated in an acute dextran sodium sulphate induced model of colitis. Nine-week-old female mice were divided into 12 groups, receiving either drinking water or 2.75% dextran sodium sulphate for 7 days, combined with a daily gavage of various treatments with different levels of acetate accumulation: sham control (phosphate buffered saline, no acetate), non-probiotic control (Baker’s yeast, no acetate), probiotic control (Enterol®, transient acetate), and additionally several Saccharomyces cerevisiae var. boulardii strains with respectively no, high, and extra-high acetate accumulation. Disease activity was monitored daily, and feces samples were collected at different timepoints. On day 14, the mice were sacrificed, upon which blood and colonic tissue were collected for analysis. Disease activity in inflamed mice was lower when treated with the high-acetate-producing strain compared to sham and non-probiotic controls. The non-acetate-producing strain showed higher disease activity compared to the acetate-producing strains. Accordingly, higher histologic inflammation was observed in non- or transient-acetate-producing strains compared to the sham control, whereas this increase was not observed for high- and extra-high-acetate-producing strains upon induction of inflammation. These anti-inflammatory findings were confirmed by transcriptomic analysis of differentially expressed genes. Moreover, only the strain with the highest acetate production was superior in maintaining a stable gut microbial alpha-diversity upon inflammation. These findings support new possibilities for acetate-mediated management of inflammation in inflammatory bowel disease by administrating high-acetate-producing Saccharomyces cerevisae var. boulardii strains.
Postprandial Blood Glucose and Insulin Response in Healthy Adults When Lentils Replace High-Glycemic Index Food Ingredients in Muffins, Chilies and Soups
Authors: Chamoun Dita , Duncan Alison M. , Lukus Patricia K. , Loreto Michael D. , Pals-Horne Frances , Hawke Aileen , Ramdath D. Dan
Published: August 2024

Objectives: This study aimed to assess postprandial blood glucose response (PBGR), relative glycemic response (RGR) and insulin response when 25 g available carbohydrates (AC) is replaced with cooked lentils in the formulation of muffins, chilies and soups. Methods: In randomized, crossover studies, healthy adults consumed foods containing 25 g AC from green lentils, red lentils or a control (wheat muffin, n = 24; rice chili, n = 24; potato soup, n = 20). Blood collected at fasting and at 15, 30, 45, 60, 90 and 120 min was analyzed to derive the incremental area under the response curve (iAUC) for glucose, insulin, RGR and maximum concentration (CMAX). Treatment effects were assessed with repeated measures ANOVA. Results: A replacement of 25 g AC with green lentils significantly decreased glucose iAUC compared to chili and soup (p < 0.0001), but not muffin (p = 0.07) controls, while also eliciting a significantly lower insulin iAUC for all three foods (muffin p = 0.03; chili p = 0.0002; soup p < 0.0001). Red lentil foods significantly decreased glucose iAUC (muffin p = 0.02; chili p < 0.0001; soup p < 0.0001) compared to controls, with a significantly lower insulin iAUC for chili and soup (p < 0.0001) but not muffins (p = 0.09). The RGR for muffins, chilies and soups was 88, 58 and 61%, respectively, for green lentils, and 84, 48 and 49%, respectively, for red lentils. Conclusions: PBGR, insulin and RGR are decreased when lentils are incorporated into food products, providing credible evidence to promote carbohydrate replacement with lentil-based foods.