bluuebunny/crossref_metadata_2025 huggingface dataset:
Spatial control of doping in conducting polymers enables complementary, conformable, implantable internal ion-gated organic electrochemical transistors
Authors: Wisniewski Duncan J. , Ma Liang , Rauhala Onni J. , Cea Claudia , Zhao Zifang , Ranschaert Alexander , Gelinas Jennifer N. , Khodagholy Dion
Published: January 2025

Complementary transistors are critical for circuits with compatible input/output signal dynamic range and polarity. Organic electronics offer biocompatibility and conformability; however, generation of complementary organic transistors requires introduction of separate materials with inadequate stability and potential for tissue toxicity, limiting their use in biomedical applications. Here, we discovered that introduction of source/drain contact asymmetry enables spatial control of de/doping and creation of single-material complementary organic transistors from a variety of conducting polymers of both carrier types. When integrated with the vertical channel design and internal ion reservoirs of internal ion-gated organic electrochemical transistors, we produced matched complementary IGTs (cIGTs) that formed high-performance conformable amplifiers with 200 V/V uniform gain and 2 MHz bandwidth. These amplifiers showed long-term in vivo stability, and their miniaturized biocompatible design allowed implantation in developing rodents to monitor network maturation. cIGTs expand the use of organic electronics in standard circuit designs and enhance their biomedical potential.
The Psu protein of phage satellite P4 inhibits transcription termination factor ρ by forced hyper-oligomerization
Authors: Gjorgjevikj Daniela , Kumar Naveen , Wang Bing , Hilal Tarek , Said Nelly , Loll Bernhard , Artsimovitch Irina , Sen Ranjan , Wahl Markus C.
Published: January 2025

Many bacteriophages modulate host transcription to favor expression of their own genomes. Phage satellite P4 polarity suppression protein, Psu, a building block of the viral capsid, inhibits hexameric transcription termination factor, ρ, by presently unknown mechanisms. Our cryogenic electron microscopy structures of ρ-Psu complexes show that Psu dimers clamp two inactive, open ρ rings and promote their expansion to higher-oligomeric states. ATPase, nucleotide binding and nucleic acid binding studies revealed that Psu hinders ρ ring closure and traps nucleotides in their binding pockets on ρ. Structure-guided mutagenesis in combination with growth, pull-down, and termination assays further delineated the functional ρ-Psu interfaces in vivo. Bioinformatic analyses revealed that Psu is associated with a wide variety of phage defense systems across Enterobacteriaceae, suggesting that Psu may regulate expression of anti-phage genes. Our findings show that modulation of the ρ oligomeric state via diverse strategies is a pervasive gene regulatory principle in bacteria.
Controlling few-body reaction pathways using a Feshbach resonance
Authors: Haze Shinsuke , Li Jing-Lun , Dorer Dominik , D’Incao José P. , Julienne Paul S. , Tiemann Eberhard , Deiß Markus , Hecker Denschlag Johannes
Published: January 2025

Gaining control over chemical reactions at the quantum level is a central goal of cold and ultracold chemistry. Here we demonstrate a method for coherently steering the reaction flux across different product spin channels for a three-body recombination process in a cloud of trapped cold atoms. We use a magnetically tunable Feshbach resonance to admix, in a controlled way, a specific spin state to the reacting collision complex. This allows us to control the reaction flux into the admixed spin channel, which can be used to alter the reaction products. We also investigate the influence of an Efimov resonance on the reaction dynamics, observing a global enhancement of three-body recombination without favouring particular reaction channels. Our control scheme can be extended to other reaction processes and could be combined with other methods, such as quantum interference of reaction paths, to achieve further tuning capabilities of few-body reactions.
Impact of RSVpreF vaccination on reducing the burden of respiratory syncytial virus in infants and older adults
Authors: Du Zhanwei , Pandey Abhishek , Moghadas Seyed M. , Bai Yuan , Wang Lin , Matrajt Laura , Singer Burton H. , Galvani Alison P.
Published: January 2025

Respiratory syncytial virus (RSV) causes a substantial health burden among infants and older adults. Prefusion F protein-based vaccines have shown high efficacy against RSV disease in clinical trials, offering promise for mitigating this burden through maternal and older adult immunization. Employing an individual-based model, we evaluated the impact of RSV vaccination on hospitalizations and deaths in 13 high-income countries, assuming that the vaccine does not prevent infection or transmission. Using country-specific vaccine uptake rates for seasonal influenza, we found that vaccination of older adults would prevent hospitalizations by a median of 35–64% across the countries studied here. Vaccination of pregnant women could avert infant hospitalizations by 5–50%. Reductions in RSV-related mortality mirrored those estimated for hospitalizations. While substantial hospitalization costs could be averted, the impact of vaccination depends critically on uptake rates. Enhancing uptake and accessibility is crucial for maximizing the real-world impact of vaccination on reducing RSV burden among vulnerable populations.
Indirect evidence of an early mating advantage in wild cooperatively breeding male banded mongooses
Authors: Birch Graham , Cant Michael A. , Nichols Hazel J. , Meniri Magali , Businge Robert , Mwanguhya Francis , Blount Jonathan D.
Published: January 2025

Promiscuous females reduce male reproductive control. Males can attempt to monopolise access to these females, but distractions and sneaky rivals mean extra copulations cannot always be blocked. By mating first, males can obtain a headstart in sperm competition, but this may be negated by sperm storage and cryptic female choice mechanisms. We carry out an indirect rare test of an early mating advantage in a population of free-living wild animals. Using Bayesian GLMM analysis of a long-term life history database spanning 17 years, we show that banded mongoose males who interacted with females in earlier days of oestrus had a higher chance of siring their offspring compared with later rivals. An early mating advantage would intensify initial male-male competition and hence selection for male choice, as any initial mistake identifying preferred mating partners could see paternity lost to rivals.
Population genomics and connectivity of Vazella pourtalesii sponge grounds of the northwest Atlantic with conservation implications of deep sea vulnerable marine ecosystems
Authors: Patova Anna , Ribeiro Pedro A. , Murillo Francisco J. , Riesgo Ana , Taboada Sergi , Pomponi Shirley A. , Rapp Hans Tore , Kenchington Ellen , Xavier Joana R.
Published: January 2025

Sponges are key ecosystem engineers that shape, structure and enhance the biodiversity of marine benthic communities globally. Sponge aggregations and reefs are recognized as vulnerable marine ecosystems (or VMEs) due to their susceptibility to damage from bottom-contact fishing gears. Ensuring their long-term sustainability, preservation, and ecosystem functions requires the implementation of sound scientific conservation tools. Here, the genetic diversity, structure, and connectivity of the deep-sea glass sponge, Vazella pourtalesii (Schmidt, 1870), was investigated using 1,102 neutral SNPs obtained in RADseq. This species is distributed across the northwest Atlantic from Florida, USA to Nova Scotia, Canada and we sequenced samples covering this full distribution and provided evidence of strong genetic structure with two distinct clusters: Florida together with the Carolina Shelves and the Scotian Shelf. We estimated moderate levels of diversity with low migration across large distances (> 1000 kms) and high connectivity at smaller scales (< 300 kms). Further, fishing pressure on genetic diversity was evaluated, within two Sponge Conservation Areas (SCAs) on the Scotian Shelf. Those areas have different disturbance histories, and cumulative fishing pressure. Slightly lower levels of genetic diversity were found inside the SCAs, and yet they encompassed a high proportion of the diversity observed within the Scotian Shelf. We provide baseline data for future monitoring of the SCAs, discussing our findings in the light of existing area-based management tools.
A retrospective cohort study of the application of Santulli enterostomy in neonatal necrotizing enterocolitis
Authors: Fu Zhe , Zhang Jingmin , Qin Fanyue , Wang Xinru , Huang Hua , Huang Hongwei , Zheng Mingjun , Wang Peng , Zhang Weibo , Shi Hongguang
Published: January 2025

The use of Santulli enterostomy (SE) for necrotizing enterocolitis (NEC) has been limited to a small number of studies involving a small number of patients and no control group. Our study aimed to compare the clinical safety and efficacy of Santulli enterostomy with those of single- or double-lumen enterostomy for neonatal NEC through a retrospective cohort study. One hundred ten patients who met the criteria were divided into an SE group (64 patients) and a conventional enterostomy (CE) group (46 patients). The CE group underwent single- or double-lumen enterostomy. There were no significant differences in complication rates or prognoses between the two groups after either procedure. Although the stoma was positioned higher in the SE group, the length of the unused small intestine (USI) was not significantly different. Multivariate analysis revealed that the length of the USI influenced the likelihood of malnutrition after enterostomy (OR = 1.108, P = 0.008). After stoma closure, compared with those in the CE group, the operation time, intestinal recovery time, fasting time, hospitalization time, intraoperative blood loss volume and the incidence of complications requiring surgical reintervention was significantly lower in the SE group. In conclusion, Santulli enterostomy is not only a safe treatment option for NEC but also an effective method for increasing the length of the small intestine after enterostomy, thereby improving the patient’s postoperative nutritional status. In addition, the procedure is associated with good recovery and a reduced incidence of surgical reintervention after stoma closure.
Silver nanoparticles coated with metabolites of Pseudomonas sp. N5.12 inhibit bacterial pathogens and fungal phytopathogens
Authors: Plokhovska Svitlana , García-Villaraco Ana , Lucas Jose Antonio , Gutierrez-Mañero Francisco Javier , Ramos-Solano Beatriz
Published: January 2025

The synthesis of nanomaterials from PGPB is an exciting approach and it’s often used in agriculture as nano-fertilizers and nano-pesticides. The present study reports a new approach to biosynthesis of silver nanoparticles (AgNP), using bacterial metabolites as agents to reduce Ag+, which will remain as coating agents able to prevent microbial growth. Silver NP were biosynthesized using the bacterial metabolites produced by the beneficial strain Pseudomonas sp. N5.12. Optimization of physicochemical parameters (temperature, pH, and AgNO3 concentration) for the synthesis of AgNP was carried out. In each condition, success on AgNP synthesis was determined by UV–Visible spectra showing peaks between 400 and 450 nm. TEM analysis showed that the AgNP are spherical in shape with an average particle size ranging from 13.75 ± 0.47 nm to 20.71 ± 0.43 nm, covered with a unique organic matter corona of bacterial metabolites. The best parameters for AgNP biosynthesis by Pseudomonas sp. N5.12 occurred with 24 h bacterial metabolites, temperature of 37 °C, pH 9 and a ratio of 2:4 (v: v; bacterial supernatant: 1 mM AgNO3). The biosynthesized AgNP inhibited growth of human pathogenic bacteria better than equivalent AgNO3 concentration. Growth of bacterial and fungal phytopathogens was also inhibited with striking effects on Alternaria sp. (74% inhibition) and Stemphylium sp. (52% inhibition), appearing as promising tools to biocontrol fungal diseases in agriculture.
A CRISPR-Cas9 system protecting E. coli against acquisition of antibiotic resistance genes
Authors: Lee Danna , Muir Petra , Lundberg Sara , Lundholm August , Sandegren Linus , Koskiniemi Sanna
Published: January 2025

Antimicrobial resistance (AMR) is an increasing problem worldwide, and new treatment options for bacterial infections are direly needed. Engineered probiotics show strong potential in treating or preventing bacterial infections. However, one concern with the use of live bacteria is the risk of the bacteria acquiring genes encoding for AMR or virulence factors through horizontal gene transfer (HGT), and the transformation of the probiotic into a superbug. Therefore, we developed an engineered CRISPR-Cas9 system that protects bacteria from horizontal gene transfer. We synthesized a CRISPR locus targeting eight AMR genes and cloned this with the Cas9 and transacting tracrRNA on a medium copy plasmid. We next evaluated the efficiency of the system to block HGT through transformation, transduction, and conjugation. Our results show that expression of the CRISPR-Cas9 system successfully protects E. coli MG1655 from acquiring the targeted resistance genes by transformation or transduction with 2–3 logs of protection depending on the system for transfer and the target gene. Furthermore, we show that the system blocks conjugation of a set of clinical plasmids, and that the system is also able to protect the probiotic bacterium E. coli Nissle 1917 from acquiring AMR genes.
Trees shape the soil microbiome of a temperate agrosilvopastoral and syntropic agroforestry system
Authors: Vaupel Anna , Küsters Max , Toups Julia , Herwig Nadine , Bösel Benedikt , Beule Lukas
Published: January 2025

Agroforestry systems are multifunctional land-use systems that promote soil life. Despite their large potential spatio-temporal complexity, the majority of studies that investigated soil organisms in temperate cropland agroforestry systems focused on rather non-complex systems. Here, we investigated the topsoil and subsoil microbiome of two complex and innovative alley cropping systems: an agrosilvopastoral system combining poplar trees, crops, and livestock and a syntropic agroforestry system combining 35 tree and shrub species with forage crops. Increasing soil depth resulted in a decline of bacterial and fungal richness and a community shift towards oligotrophic taxa in both agroforestry systems, which we attribute to resource-deprived conditions in subsoil. At each soil depth, the microbiome of the tree rows was compositionally distinct from the crop rows. We detected a shift towards beneficial microorganisms as well as a decline in putative phytopathogens under the trees as compared to the crop rows. Finally, based on our results on community dissimilarity, we found that compared to an open cropland without trees, spatial heterogeneity introduced by the tree rows in the agrosilvopastoral system translated into a compositionally less homogeneous soil microbiome, highlighting the potential of agroforestry to counteract the homogenization of the soil microbiome through agriculture.
Human iPSC-derived microglial cells protect neurons from neurodegeneration in long-term cultured adhesion brain organoids
Authors: Chen Xianwei , Sun Guoqiang , Feng Lizhao , Tian E , Shi Yanhong
Published: January 2025

Brain organoid models have greatly facilitated our understanding of human brain development and disease. However, key brain cell types, such as microglia, are lacking in most brain organoid models. Because microglia have been shown to play important roles in brain development and pathologies, attempts have been made to add microglia to brain organoids through co-culture. However, only short-term microglia-organoid co-cultures can be established, and it remains challenging to have long-lasting survival of microglia in organoids to mimic long-term residency of microglia in the brain. In this study, we developed an adhesion brain organoid (ABO) platform that allows prolonged culture of brain organoids (greater than a year). Moreover, the long-term (LT)-ABO system contains abundant astrocytes and can support prolonged survival and ramification of microglia. Furthermore, we showed that microglia in the LT-ABO could protect neurons from neurodegeneration by increasing synaptic density and reducing p-Tau level and cell death in the LT-ABO. Therefore, the microglia-containing LT-ABO platform generated in this study provides a promising human cellular model for studying neuron-glia and glia-glia interactions in brain development and the pathogenesis of neurodegenerative diseases such as Alzheimer’s disease.
State-level policies alone are insufficient to meet the federal food waste reduction goal in the United States
Authors: Kakadellis Sarah , Mao Selena , Harwood Asch , Spang Edward S.
Published: January 2025

The United States Food Loss and Waste Reduction Goal seeks to reduce national food waste by 50%, down to 74 kg per capita, by 2030. Here we investigate state policies’ alignment with the federal goal across four policy categories. We develop a policy scoring matrix and apply it to wasted food solutions listed in the non-profit ReFED’s database to derive ranges of food waste diversion potential and projected generation across states. On the basis of state policies alone, no state can meet the federal target. We estimated a diversion potential of 5–14 kg per capita and a food waste generation of 149 kg per capita nationally in 2022, equivalent to the 2016 baseline. Without additional intervention at the state and federal level promoting a shift from food waste recycling towards prevention, rescue and repurposing, food generation in the United States will probably remain high.
RNA dysregulation in neurodegenerative diseases
Authors: Li Yini , Sun Shuying
Published: January 2025

Dysregulation of RNA processing has in recent years emerged as a significant contributor to neurodegeneration. The diverse mechanisms and molecular functions underlying RNA processing underscore the essential role of RNA regulation in maintaining neuronal health and function. RNA molecules are bound by RNA-binding proteins (RBPs), and interactions between RNAs and RBPs are commonly affected in neurodegeneration. In this review, we highlight recent progress in understanding dysregulated RNA-processing pathways and the causes of RBP dysfunction across various neurodegenerative diseases. We discuss both established and emerging mechanisms of RNA-mediated neuropathogenesis in this rapidly evolving field. Furthermore, we explore the development of potential RNA-targeting therapeutic approaches for the treatment of neurodegenerative diseases.
Acidic pH can attenuate immune killing through inactivation of perforin
Authors: Hodel Adrian W , Rudd-Schmidt Jesse A , Noori Tahereh , Lupton Christopher J , Cheuk Veronica C T , Trapani Joseph A , Hoogenboom Bart W , Voskoboinik Ilia
Published: January 2025

Cytotoxic lymphocytes are crucial to our immune system, primarily eliminating virus-infected or cancerous cells via perforin/granzyme killing. Perforin forms transmembrane pores in the plasma membrane, allowing granzymes to enter the target cell cytosol and trigger apoptosis. The prowess of cytotoxic lymphocytes to efficiently eradicate target cells has been widely harnessed in immunotherapies against haematological cancers. Despite efforts to achieve a similar outcome against solid tumours, the immunosuppressive and acidic tumour microenvironment poses a persistent obstacle. Using different types of effector cells, including therapeutically relevant anti-CD19 CAR T cells, we demonstrate that the acidic pH typically found in solid tumours hinders the efficacy of immune therapies by impeding perforin pore formation within the immunological synapse. A nanometre-scale study of purified recombinant perforin undergoing oligomerization reveals that pore formation is inhibited specifically by preventing the formation of a transmembrane β-barrel. The absence of perforin pore formation directly prevents target cell death. This finding uncovers a novel layer of immune effector inhibition that must be considered in the development of effective immunotherapies for solid tumours.
Oncolytic viruses expressing MATEs facilitate target-independent T-cell activation in tumors
Authors: Peter Malin , Mundt Bettina , Menze Arne , Woller Norman , Volk Valery , Ernst Amanda M , Öhler Leon A , Talbot Steven R , Wedemeyer Heiner , Falk Christine , Feuerhake Friedrich , Wirth Thomas C , Kühnel Florian
Published: January 2025

Oncolytic viruses (OV) expressing bispecific T-cell engagers (BiTEs) are promising tools for tumor immunotherapy but the range of target tumors is limited. To facilitate effective T-cell stimulation with broad-range applicability, we established membrane-associated T-cell engagers (MATEs) harboring the protein transduction domain of the HIV-Tat protein to achieve non-selective binding to target cells. In vitro, MATEs effectively activated murine T cells and improved killing of MC38 colon carcinoma cells. Similarly, humanized MATEs activated T cells in PBMCs from human donors. In MC38-tumors in mice, MATE-expression by the oncolytic adenovirus Ad5/11 facilitated intratumoral T-cell activation, reduced tumor growth and prolonged survival accompanied by infiltration of tumor-directed CD8+ T cells and improved CD8/CD4 T-cell ratio. Absence of early T-cell activation in tumor draining lymph nodes suggests the safe applicability of this strategy. Furthermore, MATE-expression by Ad5/11 was capable of breaking resistance to αPD-1 checkpoint therapy thereby promoting T-cell/tumor cell proximity and clustering of CD8+ and CD4+ T cells. In summary, we demonstrated that MATE expressing OVs are powerful T-cell activating tools suitable for local immunotherapy of a broad range of tumors.
A practical fluorometric and colorimetric dual-mode sensing platform based on two-dimensional porous organic nanosheets for rapid determination of trifluralin
Authors: Liu Xue , Lu Zhenyu , Huang Shijun , Chen Na , Xiao Xue , Zhu Xiaohui , Zhang Runkun
Published: January 2025

Fluorescent two-dimensional porous organic nanosheets (PONs) were prepared via a simple ultrasonic method. A TPA-PON-based fluorometric and colorimetric dual-mode sensing platform was fabricated for rapid determination of trifluralin in vegetables.
Photodynamic therapy with photodegradable photosensitizers
Authors: Wu Haorui , Zhang Youjian , Jiang Lifen , Huang Huaiyi
Published: January 2025

Photodegradable photosensitizers minimize post-treatment side effects and improving the overall safety profile of photodynamic therapy.
A metal–organic framework with mixed electron donor and electron acceptor ligands for efficient lithium-ion storage
Authors: Wang Ruo-Nan , Tan Yu-Chuan , Liu Wei , Wang Zi-Yi , Zhang Jun-Die , Zhu Qin-Yu
Published: January 2025

A 3D MOF with mixed electron donor TTF and electron acceptor NDI ligands displays excellent rate behavior and long term cycling performance due to its multiple redox active sites and charge transfer within the framework.
Optical cavity enhancement of visible light-driven photochemical reaction in the crystalline state
Authors: Sasaki Ikuto , Takahashi Kiyonori , Taemaitree Farsai , Nakamura Takayoshi , Hutchison James A. , Uji-i Hiroshi , Hirai Kenji
Published: January 2025

Photochemical reactions enable the synthesis of energetically unfavorable compounds but often require irradiation with ultraviolet light, which potentially induces side reactions.
Metal-directed hierarchical superhelices from hybrid peptide foldamers
Authors: Dey Sanjit , Roy Souvik , Puneeth Kumar DRGKoppalu R. , Nalawade Sachin A. , Singh Manjeet , Toraskar Sandip U. , Mahapatra Souvik Panda , Gopi Hosahudya N.
Published: January 2025

Metal-directed transformation of a α,γ-hybrid peptide 12-helix into a right-handed superhelix is described.
N-Monoarylated dihydrophenazines in reduced and oxidized states as efficient organo-photocatalysts
Authors: Prato Maurizio , Dosso Jacopo
Published: January 2025

A novel dihydrophenazine-based organo-photocatalyst enables different reactivities depending on its oxidation state.
Structural analysis, in vitro anti-tubercular activities, and in silico ADMET evaluation of ethyl 7-methoxy-3-(4-substituted benzoyl)indolizine-1-carboxylates
Authors: Nagdeve Rahul D. , Thakur Jyoti Swarup , Chandrashekharappa Sandeep , Mondal Pradip Kumar , Deb Pran Kishore , Polentarutti Maurizio , Bairagi Keshab M. , Rakshit Gourav , Alwassil Osama I. , Pillay Melendhran , Venugopala Katharigatta N. , Nayak Susanta K.
Published: January 2025

A series of indolizine derivatives were synthesized and characterized by SC-XRD and computational analysis to investigate their structural aspects, as well as their anti-tubercular activity, with varying substituents.
Evolution of electronic structure and optical properties of naphthalenediimide dithienylvinylene (NDI-TVT) polymer as a function of reduction level: a density functional theory study
Authors: Jena Sushri Soumya , Garg Mohit , Ghosh Sarbani
Published: January 2025

This study shows the evolution of polaron/bipolaron formation during the reduction of an n-type polymer, naphthalenediimide dithienylvinylene (NDI-TVT), and how the optical absorption spectra evolve with reduction levels in gas and solvent phases.
Partial framework-Al in lamellar H-[Al]-RUB-18: acidity by probe TMPO adsorption and catalytic study in the presence and absence of water
Authors: Sousa Paulla B. F. , Albuquerque Elise M. , Fraga Marco A. , Pastore Heloise O.
Published: January 2025

The present study clarifies the acidity features of aluminol sites on lamellar [Al]-RUB-18 and brings attention to the evaluation of solid catalysts under aqueous-phase conditions.
Noble-metal-like catalysts of carbide and nitride for the low-temperature water–gas shift reaction: a review
Authors: Shao Tongrui , Li Lichao , Lin Jian
Published: January 2025

TMC/Ns can efficiently catalyze the low-temperature WGS reaction due to its noble-metal-like properties and has potential to develop sustainable industrial hydrogen production technologies.
Pressure-induced phase transitions in a new luminescent gold(i)–arylacetylide
Authors: Dziewiątkowska Róża , Krzeszczakowska Joanna , Głodek Marta , Łomzik Michał , Plażuk Damian , Makal Anna
Published: January 2025

Conformational changes in a new gold(i)–arylacetylide triethylphosphine, proceeding by means of the molecular gearing mechanism, ensure propensity for reversible pressure-induced single-crystal-to-single-crystal (SCSC) phase transitions.
Understanding non-reducible N2 in the mechanism of Mo–nitrogenase
Authors: Dance Ian
Published: January 2025

Computed thermodynamics explain the two separate roles of N2 in the mechanism of Mo–nitrogenase.
Application of the aza-Wittig reaction for the synthesis of carboranyl Schiff bases, benzothiazoles and benzoselenazolines
Authors: Crujeiras Pablo , Vázquez-Carballo Irene , Sousa-Pedrares Antonio
Published: January 2025

The aza-Wittig reaction was successfully applied to the synthesis of a variety of functionalized carboranyl-imines. This methodology can be modified to permit the synthesis in one step of carboranyl-benzothiazole and benzoselenazoline derivatives.
Towards the photodeposition of SixGey-type materials via oligomers of cyclogermapentenes and cyclosilapentenes
Authors: Medroa del Pino William , Forero Pico Andres , Muralidharan Abhishek V. , Gupta Manisha , Rivard Eric
Published: January 2025

The deposition of mixed element films of Si, SixGey-type materials and amorphous carbon is reported from the photolysis of pre-assembled group 14 element oligomers at room temperature.
Deep reconstruction of a Mo-based electrocatalyst for high-performance water/seawater oxidation at ampere-level current density
Authors: Sun Jianpeng , Zhou Shuai , Zhao Zhan , Qin Shiyu , Meng Xiangchao , Tung Chen-Ho , Wu Li-Zhu
Published: January 2025

A deep reconstructed amorphous FeMoOOH/NF catalyst was designed and characterized, exhibiting low overpotential and high stability in both alkaline aqueous solution and seawater.
19.46%-Efficiency all-polymer organic solar cells with excellent outdoor operating stability enabled by active layer reconstruction
Authors: Wu Xiaohei , Xiao Bo , Sun Rui , Yang Xinrong , Zhang Meimei , Gao Yuan , Xiao Biao , Papkovskaya Elizaveta D. , Luponosov Yuriy , Brabec Christoph J. , Min Jie
Published: January 2025

Layer-by-layer blade deposition was employed along with a multi-component strategy to construct a quaternary all-polymer system, achieving a high power conversion efficiency of 19.46% and improved outdoor operating stability.
Environmental drivers of monomethylmercury photodegradation along the land-to-ocean aquatic continuum
Authors: Gindorf Sonja , West Johannes , Graham Andrew , Jonsson Sofi
Published: January 2025

Monomethylmercury (MMHg) photodegradation along the land-to-ocean aquatic continuum is affected by dissolved organic matter (DOM) composition, concentration, and salinity.
Adherence to a healthy dietary pattern mitigates the detrimental associations between osteosarcopenic adiposity and both all-cause mortality and life expectancy: a cohort study
Authors: Ma Yixuan , Wang Hengjun , Yang Honghao , Hong Weihao , Xu Hehao , Chen Liangkai , Zhang Bing , Ji Chao , Xia Yang
Published: January 2025

Osteosarcopenic adiposity is significantly associated with increased all-cause mortality and reduced life expectancy but adhering to a healthy diet low in processed meat and high in fish can help mitigate these adverse effects.
Biocompatible PMAO-coated Gd2O3/Fe3O4 composite nanoparticles as an effective T1–T2 dual-mode contrast agent for magnetic resonance imaging
Authors: Tam Le T. T. , Linh Nguyen T. N. , Tam Le T. , Thiet Duong V. , Nam Pham H. , Hoa Nguyen T. H. , Tuan Le A. , Dung Ngo T. , Lu Le T.
Published: January 2025

Gd2O3/Fe3O4 composite nanoparticles with a unique structure were successfully synthesized using a simple and effective approach, exhibiting superior T1–T2 dual-modality MRI performance.
Environmentally tolerant multifunctional eutectogel for highly sensitive wearable sensors
Authors: Wei Zhengen , Jia Lianghao , Yu Jinyu , Xu Hanrui , Guo Xing , Xiang Tao , Zhou Shaobing
Published: January 2025

Environmentally tolerant multifunctional eutectogel crosslinked by interactions and electrostatic attractions is applied for wearable sensors with high sensitivity.
Multifunctional applications enabled by tunable multi-emission and ultra-broadband VIS-NIR luminescence via energy transfer in Sn2+/Mn2+-doped lead-free Zn-based metal halides
Authors: Yang Yongqi , Ke Bao , Yang Chengzhi , Xue Yang , Huang Kaihuang , Lu Xintong , Zou Bingsuo
Published: January 2025

Tunable multi-emission and ultra-broadband visible to near-infrared luminescence in Sn2+/Mn2+-doped lead-free Zn-based metal halides have been achieved by adjusting the doping ratios and excitation wavelengths.
Investigating the structure–property correlations of pyrolyzed phenolic resin as a function of degree of carbonization
Authors: Gallegos Ivan , Varshney Vikas , Kemppainen Josh , Odegard Gregory M.
Published: January 2025

Carbon–carbon (C/C) composites are attractive materials for high-speed flights and terrestrial atmospheric reentry applications due to their insulating thermal properties, thermal resistance, and high strength-to-weight ratio.
Pyrroloquinoline Quinone-Loaded Coaxial Nanofibers Prevent Oxidative Stress after Spinal Cord Injury in Rats
Authors: Ibrahim Sara , Ismail Mohamed , Abdelrahman Taghrid , Sharkawy Mona , Abdellatif Ahmed , Allam Nageh
Published: January 2025

Oxidative stress plays a major role in the secondary injury of the spinal cord tissue due to the nervous tissue high lipid content. In the present study, coaxial nanofibers were...
Orthovanadate cofactor chemistry of marine bromoperoxidases
Authors: Hartung Jens
Published: January 2025

Cofactor bonding, hydrogen peroxide activation, and bromide oxidation by marine bromoperoxidases are explained in a unified model, based on quantitative approaches for scaling peroxide electrophilicity and orthovanadate hydrogen bonding.
A study on the end-point determination of the Xuefu Zhuyu capsule raw powder mixing process based on near-infrared spectroscopy
Authors: Wang Xi , Fang Guangpu , Qian Jiahe , Zhang Shule , Song Wen , Zhang Ying , Li Zheng , Wang Yi , Li Wenlong
Published: January 2025

Near-infrared (NIR) spectroscopy technology combined with chemometric algorithms was used to determine the mixing end-point of Xuefu Zhuyu capsule raw powder and find the shortest mixing time.
Synthesis, photophysical, electrochemical, and spectroelectrochemical properties of the β-pyrrole functionalized push–pull porphyrins
Authors: Krishna Amiy , Misra Rajneesh
Published: January 2025

A set of β-pyrrole functionalized phenothiazine, phenothiazine 5,5-dioxide, carbazole, and ferrocenyl porphyrins were synthesized, and their photophysical, electrochemical, and spectroelectrochemical properties were thoroughly investigated.
Broadband and large surface enhancements of the local electric field enabled by cross-etched hyperbolic metamaterials
Authors: Li Zixian , Zhang Houjiao , Shi Zhonghong , Li Haoyang , He Guoli , Qiu Shuang , Zhou Zhang-Kai
Published: January 2025

This work presents a novel cross-etched HMM (CeHMM), which can exhibit two resonant high-k modes under incident light from free space and provide large enhancements of surface electric fields over a broadband spectral range extending beyond 500 nm.
A straightforward process manipulates the dramatic morphological changes of DNA rolling circle amplification products
Authors: Xu Li , Wang Han , Yang Yining , Zhang Han , Fang Shuqi , Zhao Yuchen , Zhang Tianjing , Zhang Xianzheng , Zhao Jiemin , Zhang Lingling
Published: January 2025

We introduce a method to modify the morphology of RCA products from nanoparticles to macro-hydrogels. This is accomplished by implementing an additional cold treatment step on a circular DNA template before its extension with phi29 DNA polymerase.
The BeP2 monolayer exhibits ultra-high and highly anisotropic carrier mobility and 29.3% photovoltaic efficiency
Authors: Sun Changping , Zhang Yiming , Xu Meiling , Wang Feilong , Cui Wenwen , Niu Caoping , Li Yinwei
Published: January 2025

We predict that the hex-BeP2 monolayer exhibits a high electron mobility on the order of 105 cm2 V−1 s−1, along with a remarkable photovoltaic efficiency of 29.3%.
Ferroelectricity enhances ion migration in hard carbon anodes for high-performance potassium ion batteries
Authors: Rui Li , Keyu An , Hao Ouyang , Heng Li , Yanyan Zhang , Yuxin Tang , Jilei Liu , Shi Chen
Published: January 2025

Ferroelectric BTO particle embedded hard carbon anodes accelerate potassium ion migration and result in better electrochemical performance.
Improvement of adsorption of sulfadiazine on tannic acid–chitosan biochar by nickel doping through a polyphenol metal network
Authors: Xu Zhuo , Shao Gaosong , Liang Zhi , Jiang Dingding , Wang Xianwei , Wen Yuhao , Lu Peiyuan
Published: January 2025

In this paper, nickel was successfully loaded onto the surface of chitosan via polyphenol metal network and carbonized to form biochar material, which adsorbed 123.89 mg g−1 and 152.56 mg g−1 of SDZ at 298 K and 318 K, respectively.
Chirality of sub-nanometer nanowires/nanobelts
Authors: Xing Kaiyang , Hui Junfeng , Zhang Simin
Published: January 2025

In this review, we summarize the origination, transfer and amplification of chirality in sub-nanometer nanowires/nanobelts (SNWs/SNBs).
Preparation of a new class of phosphonated hydrocarbon polymers based on polysulfone
Authors: Martschin Philipp , Prölß Timo , Hutzler Andreas , Thiele Simon , Kerres Jochen
Published: January 2025

Pentafluorophenyl phosphonic acid group-containing PSU derivatives synthesized via a simple one-pot approach represent promising materials for (high-temperature) PEM fuel cells, (high-temperature) PEM water electrolysis, or redox flow batteries.
A new fluorescent oxaliplatin(iv) complex with EGFR-inhibiting properties for the treatment of drug-resistant cancer cells
Authors: Caban Monika , Fronik Philipp , Terenzi Alessio , Federa Anja , Bormio Nunes Julia H. , Pitek Rastislav , Kirchhofer Dominik , Schueffl Hemma H. , Berger Walter , Keppler Bernhard K. , Kowol Christian R. , Heffeter Petra
Published: January 2025

KP2749 is a new anticancer agent that releases two independent cytotoxic agents upon reduction: oxaliplatin and the fluorescent EGFR inhibitor KP2187.
Synthesis of 2-arylchromeno[2,3,4,5-lmna]phenanthridines through a sequential multicomponent assembly, oxygenation and 6πe electrocyclization reactions
Authors: Pawar Anil Rangnath , Yashmin Sabina , Khan Abu Taleb
Published: January 2025

A single-step synthesis of 2-arylchromeno[2,3,4,5-lmna]phenanthridines is disclosed using a MCR and cascade reactions. Here, DMSO reacts for regioselective ‘O’ transposition and assists in situ 6πe electrocyclization and aromatization reactions.
Access to (bridged) bicyclic ureas through azocarboxamide-enabled enantioselective 1,2-diamination of α-branched cyclic ketones
Authors: Li Li , Li Yuan-Yang , Li Bei-Bei , Shi Linlin , Gao Beiling , Mei Guang-Jian
Published: January 2025

Reported here is the azocarboxamide-enabled enantioselective 1,2-diamination of α-branched cyclic ketones. A wide range of fused and bridged bicyclic ureas were prepared in good yield with excellent enantioselectivity.
The Giese reaction of alkyl bromides using amine carboxyboranes
Authors: Park Changhee , Gi Seyun , Yoon Seongkyeong , Kwon Seong Jung , Lee Sunggi
Published: January 2025

The Giese reaction of alkyl bromides was achieved using amine carboxyboranes as ligated boryl radical precursors. Furthermore, ligated boryl radicals were utilized to establish carbon–boron bonds.
Self-optimising continuous-flow hydrothermal reactor for nanoparticle synthesis
Authors: Jackson Cameron , Robertson Karen , Sechenyh Vitaliy , Chamberlain Thomas W. , Bourne Richard A. , Lester Edward
Published: January 2025

Schematic of autonomous high-throughput reactor for metal oxide nanoparticle synthesis. ML: machine learning.
Flat-plate mesophotoreactor with a serpentine channel and inclined baffles for balancing mixing performance and reaction throughput
Authors: Chen Shuaiyu , Lv Qianrui , Li Fujun , Wang Yuchao , Yang Wenbo , Liu Zhimei , Miskevich Alexander A. , Loiko Valery A. , Tao Shengyang , Zhang Lijing
Published: January 2025

Introducing baffles in the curved channels of serpentine mesoreactors can effectively enhance mixing, resulting in the reaction yields comparable to microreactors, while also achieving a significant increase in reaction throughput.
Evolution of amorphous ruthenium nanoclusters into stepped truncated nano-pyramids on graphitic surfaces boosts hydrogen production from ammonia
Authors: Chen Yifan , Young Benjamin J. , Aliev Gazi N. , Kordatos Apostolos , Popov Ilya , Ghaderzadeh Sadegh , Liddy Thomas J. , Cull William J. , Kohlrausch Emerson C. , Weilhard Andreas , Hutchings Graham J. , Besley Elena , Theis Wolfgang , Alves Fernandes Jesum , Khlobystov Andrei N.
Published: January 2025

Atomic-scale changes can significantly impact heterogeneous catalysis, yet their atomic mechanisms are challenging to establish using conventional analysis methods.
Fluorinated and methylated ortho-benzodipyrrole-based acceptors suppressing charge recombination and minimizing energy loss in organic photovoltaics
Authors: Wang Yan-Bo , Tsai Chia-Lin , Xue Yung-Jing , Jiang Bing-Huang , Lu Han-Cheng , Hong Jun-Cheng , Huang Yu-Chi , Huang Kuo-Hsiu , Chien Su-Ying , Chen Chih-Ping , Cheng Yen-Ju
Published: January 2025

Two ortho-benzodipyrrole-based non-fullerene acceptors, CFB and CMB, have been developed to reduce charge recombination and energy loss in organic photovoltaics.
Functionally active modulators targeting the LRRK2 WD40 repeat domain identified by FRASE-bot in CACHE Challenge #1
Authors: Mettu Akhila , Glavatskikh Marta , Wang Xiaowen , Lara Ordóñez Antonio Jesús , Li Fengling , Chau Irene , Ackloo Suzanne , Arrowsmith Cheryl , Bolotokova Albina , Ghiabi Pegah , Gibson Elisa , Halabelian Levon , Houliston Scott , Harding Rachel J. , Hutchinson Ashley , Loppnau Peter , Perveen Sumera , Seitova Almagul , Zeng Hong , Schapira Matthieu , Taymans Jean-Marc , Kireev Dmitri
Published: January 2025

FRASE-bot, a virtual screening platform, won CACHE Challenge #1, which aimed to identify ligands to WDR LRRK2, a Parkinson's disease target. The hit compounds exibit low micromolar affinity for the target and modulate LRRK2 function in cells.
A novel high-entropy layered cathode with a robust structure and fast dynamics at high rates for Na-ion batteries
Authors: Cao Minghui , Cui Miao , Gong Yiping , Guo Zewei , Le Shuangqing , Tian Jingyang , Jiang Yuanping , Shadike Zulipiya , Lin Chong
Published: January 2025

A novel high-entropy layered cathode with a robust structure and fast dynamics has been successfully synthesized and studied, demonstrating superior high-rate performance.
Electrification of fertilizer production via plasma-based nitrogen fixation: a tutorial on fundamentals
Authors: Gromov Mikhail , Gorbanev Yury , Vervloessem Elise , Morent Rino , Snyders Rony , De Geyter Nathalie , Bogaerts Annemie , Nikiforov Anton
Published: January 2025

Plasma-based nitrogen fixation, leveraging non-thermal plasma technologies, offers a promising alternative to conventional processes, with the potential to decentralize fertilizer production, reduce CO2 emissions, and employ renewable energy sources.
Sorbent-based atmospheric water harvesting: engineering challenges from the process to molecular scale
Authors: Borne Isaiah , Cooper Andrew I.
Published: January 2025

Atmospheric water harvesting is an emerging technique that can potentially increase water access to water-constrained communities.
Advancing Li3VO4 with high coulombic efficiency and super lithium storage by interface in situ regulation
Authors: Wang Chengwei , Pei Cunyuan , Lei Lei , Chen Zhiheng , Zhang Dongmei , Sun Bing , Li Pengju , Ma Huijuan , Shen Zexiang , Ni Shibing
Published: January 2025

The highly dispersed Ni nanoparticles can catalyze the decomposition of Li2O, leading to a thinner and denser SEI layer. This results in a higher initial Coulombic efficiency and improved cycling stability for LVO/Ni/C.
Exsolved medium-entropy alloy FeCoCuNi in titanate fibers enables solid oxide cells with superb electrochemical performance
Authors: Zhou Zilin , Cui Jiajia , Liu Zhengrong , Yang Jiaming , Sun Yueyue , Yin Chaofan , Xue Zixuan , Niu Jiaxi , Liu Jingze , Wu Kai , Zhou Jun
Published: January 2025

The hemp rope-liked LSTFCCN nanofibers with exsolved medium-entropy-alloy (MEA) nanoparticles are fabricated, delivering remarkably enhanced electrochemical activity both in fuel cell (FC) mode and electrolysis cell (EC) mode.
Atomically dispersed iron sites on a multi-shelled hollow structure for highly efficient CO2 fixation
Authors: Shi Changsong , Xu Ruiming , Suo Ting , Shi Xiang , Yun Ruirui
Published: January 2025

Gradually releasing reactants within a heterogeneous catalysis system is crucial to promote catalytic performance.
Engineering of hierarchical Z-scheme ZnSe/Fe2O3 heterojunction cubic nanocages for enhanced CO2 to CO photoconversion
Authors: Bao Jinyu , Chen Yajie , Li Wenpeng , Zhang Jiajia , Zeng Fanze , Liu Lu , Tian Guohui
Published: January 2025

Z-scheme ZnSe/Fe2O3 heterojunction cubic nanocages were prepared by immobilizing ZnSe nanoparticles on the prepared Fe2O3 cubic nanocages.The optimized composite exhibited an excellent CO2 photoreduction performance compared to the pristine ZnSe.
Attempts to realize promising thermoelectric performance in n-type polycrystalline SnSe with a cubic structure
Authors: Li Zhenqi , Wang Yuping , Liu Dongrui , Hong Tao , Qin Bingchao , Gao Xiang , Zhao Li-Dong
Published: January 2025

Promising thermoelectric performance at low temperatures (300–600 K) realized in n-type polycrystalline SnSe by regulating the lattice structure.
Top-down micro and nano structuring of wide bandgap semiconductors for ultraviolet photodetection
Authors: Mondal Ramit Kumar , Kim You Jin , Liao Yikai , Zheng Zhihua , Dai Jiangnan , Kim Munho
Published: January 2025

This review focuses on top-down dry and wet etching of III-nitrides, SiC, Ga2O3, and diamond to create micro/nanostructured UV photodetectors, enabling enhanced light trapping and improved device performance.
Reactive and decomposable dispersant for maximizing the properties of graphene composites
Authors: Cui Junshuo , Du Xuening , Liu Shiyi , Guo Liangyu , Liu Wanqi , Xiong Ying
Published: January 2025

A dual-functional dispersant is developed to make the most of graphene in practical applications. A graphene composite with enhanced conductivity, mechanical strength, and solvent resistance is achieved relying on the dispersant.
Supramolecular assembly of phosphonate-substituted porphyrins in Langmuir layers and Langmuir–Schäfer films: structural studies and selective sensing of pyridine vapors
Authors: Ermakova Elizaveta V. , Arslanov Vladimir V. , Bretonnière Yann , Michel Carine , Bessmertnykh-Lemeune Alla
Published: January 2025

The supramolecular assembly of octa-phosphonate-substituted porphyrins using the Langmuir–Schäfer technique allows for the selective naked-eye detection of pyridine by monolayer films.
Tropospheric alkene ozonolysis chemistry: an extended computational chemistry assessment of structural effects
Authors: Watson Nathan A. I. , Newland Mike J. , Nelson Beth S. , Rickard Andrew R. , Beames Joseph M.
Published: January 2025

A systematic computational chemistry study of alkene ozonolysis reactions to help design a new structure–activity-based taxonomic framework.
Pyrolysis of sweet lemon (Citrus limetta) waste: effect of zeolite β, ammonium on kinetics and bio-oil yield
Authors: Muhammad Faisal , Nisar Jan , Ali Ghulam , Anwar Farooq , Wan Abdul Karim Ghani Wan Azlina , Sharif Ahsan , Ahmed Ejaz
Published: January 2025

This study aims to explore the potential of citrus waste for valuable products.
Retraction: Iso-pencillixanthone A from a marine-derived fungus reverses multidrug resistance in cervical cancer cells through down-regulating P-gp and re-activating apoptosis
Authors: Chen Li , Li Xinxin , Cheng Miaomiao , Wang Siyuan , Zheng Qiuhong , Liu Qinying
Published: January 2025

Retraction of ‘Iso-pencillixanthone A from a marine-derived fungus reverses multidrug resistance in cervical cancer cells through down-regulating P-gp and re-activating apoptosis’ by Li Chen et al., RSC Adv., 2018, 8, 41192–41206, https://doi.org/10.1039/C8RA09506J.