bluuebunny/crossref_metadata_2025 huggingface dataset:
A ratiometric fluorescent dye for detection of Lys and Arg and its bioimaging in live cells and zebrafish larvae
Authors: Zhang Tongxin , Yang Zhengfei , He Xiaoyan , Guo Luxin , Wang Jincheng , Jiang Xuewen , Shen Ruling , Lu Xiuhong
Published: January 2023

Dimethyl indole Dye IDE was applied to the detection of Lys and Arg level in living cells and zebrafish larvae successfully, and it will be a useful fluorescence indicator for pH changes by Lys and Arg.
Electrospun carbon-based nanomaterials for next-generation potassium batteries
Authors: Wu Junxiong , He Jiabo , Wang Manxi , Li Manxian , Zhao Jingyue , Li Zulin , Chen Hongyang , Li Xuan , Li Chuanping , Chen Xiaochuan , Li Xiaoyan , Mai Yiu-Wing , Chen Yuming
Published: January 2023

Electrospinning is a versatile technique to synthesize one-dimensional nanomaterials for energy-storage applications. This feature article summarizes the recent developments in carbon nanofiber-based electrodes for rechargeable potassium batteries.
Reconciling membrane protein simulations with experimental DEER spectroscopy data
Authors: Mittal Shriyaa , Dutta Soumajit , Shukla Diwakar
Published: January 2023

Reconciliation of experimental and computational spectroscopic observables is critical for understanding protein dynamics.
Anion photoelectron spectroscopy and quantum chemical calculations of bimetallic niobium–aluminum clusters NbAln−/0 (n = 3–12): identification of a half-encapsulated symmetric structure for NbAl12−
Authors: Yan Shuai-Ting , Long Zhen-Chao , Xu Xi-Ling , Xu Hong-Guang , Zheng Wei-Jun
Published: January 2023

NbAl12− has a C3v symmetric half-encapsulated structure, which can be viewed as a NbAl6 regular hexagon over a bowl-shaped Al6 structure.
Structure effects of Pt15 clusters for the oxygen reduction reaction: first-principles calculations
Authors: Rodríguez-Kessler Peter L. , Muñoz-Castro Alvaro , Rodríguez-Domínguez Adán R. , Cabellos José Luis
Published: January 2023

In the present work, the lowest energy structures and electronic properties of Pt15 clusters are investigated using first-principles calculations. The catalytic activity for the oxygen reduction reaction is analyzed and discussed.
Identification of biomolecule-based electronic materials from a first-principles study of aliphatic amino acids
Authors: Du Pei , Yuan Hui , Tan Dan , Yang Rusen
Published: January 2023

Ascribed to the presence of sulphur atoms, l-Met is a biomaterial based wide bandgap (2.88 eV) p-type semiconductor. The piezoelectric voltage constant of l-Leu is more than one order of magnitude higher than that of lead zirconate titanate (PZT).
Enhancing the osmotic energy conversion of a nanoporous membrane: influence of pore density, pH, and temperature
Authors: Zheng Ding-Cheng , Hsu Jyh-Ping
Published: January 2023

Salinity gradient power, which converts Gibbs free energy of mixing to electric energy through an ion-selective pore, has great potential.
Robustness of partial denitrification-anammox (PdNA) in filters with methanol and glycerol as carbon sources
Authors: Fofana Rahil , Parsons Michael , Bachmann Megan , Jones Kimberly , Delgado Vela Jeseth , Akyon Benay , Liu Wenjun , Klaus Stephanie , deBarbadillo Christine , Bott Charles , De Clippeleir Haydee
Published: January 2023

We demonstrate the potential of partial denitrification-anammox filters to retrofit plants into sustainable and cost-effective nitrogen removal systems.
Better adherence to the MIND diet is associated with lower risk of all-cause death and cardiovascular death in patients with atherosclerotic cardiovascular disease or stroke: a cohort study from NHANES analysis
Authors: Song Yanjun , Chang Zhen'ge , Jia Lei , Song Weihua , Wang Hongjian , Dong Qiuting , Dou Kefei
Published: January 2023

Subjects with ASCVD or stroke who better adhered to the MIND diet presented a lower risk of all-cause and cardiovascular death, suggesting the MIND diet as a therapeutic dietary pattern with a great value in the secondary prevention of ASCVD.
Catalytic aerobic oxidation of lignin-based vanillyl alcohol under base–free conditions over an efficient and reusable LaFeO3 perovskite for vanillin production
Authors: Zhou Yaohong , Xiong Wanming , Jin Yujing , Wang Peng , Wei Weiqi , Ma Jiliang , Zhang Xiaohua
Published: January 2023

Conversion of lignin feedstocks into aromatic chemicals is a highly desirable target for biorefineries, whose depolymerization often requires high temperatures and harsh conditions.
High intermediate precision Sm isotope measurements in geological samples by MC-ICP-MS
Authors: Bai Jiang-Hao , Lin Mang , Zhong Song-Xiong , Deng Yi-Nan , Zhang Le , Luo Kai , Wu Hao , Ma Jin-Long , Wei Gang-Jian
Published: January 2023

A protocol for high intermediate precision Sm isotope measurements.
Self-assembly of thiolato-bridged ester-functionalized Re(i)-based tetranuclear spiro-metallacyclophanes
Authors: Varghese Jisna , Kumar Udit , Jose Shilpa , Magray Aamir Afzal , Yeswanth Kumar S. , Padmanaban R. , Manimaran Bala.
Published: January 2023

Rhenium(i) based sulfur-bridged tetranuclear spiro-metallacyclophanes of M4S2L-type were obtained via oxidative addition of diaryl disulfide to rhenium carbonyl with the simultaneous coordination of the pyridyl moiety of tetradentate ptpc ligand.
Comparison of the structure–property relationships between sillenite and perovskite phases of Bi0.9Dy0.1FeO3 nanostructures
Authors: Sharmin Fahmida , Ara Ferdous , Basith M. A.
Published: January 2023

A comprehensive comparison between sillenite and perovskite phases of Bi0.9Dy0.1FeO3 (BDFO) nanostructures synthesized by hydrothermal (HT) and sol–gel (SG) techniques.
Pyridine-amido aluminum catalyst precursors for 1,3-butadiene transition-metal-free stereospecific polymerization
Authors: Tang Jian , Xu Zijian , Liu Zelong , Fu Yuan , Hua Jing
Published: January 2023

The first transition-metal-free catalyst for the stereospecific polymerization of 1,3-butadiene.
Enhancement of thermomechanical properties of sulfur-rich polymers by post-thermal treatment
Authors: Han Nara , Cho Woongbi , Hwang Jae Hyuk , Won Sukyoung , Kim Dong-Gyun , Wie Jeong Jae
Published: January 2023

A simple and facile processing strategy to enhance the thermomechanical properties of sulfur-rich polymers has been reported.
HTE and machine learning-assisted development of iridium(i)-catalyzed selective O–H bond insertion reactions toward carboxymethyl ketones
Authors: Xu Yougen , Ren Feixiao , Su Lebin , Xiong Zhaoping , Zhu Xinwei , Lin Xinyuan , Qiao Nan , Tian Hao , Tian Changen , Liao Kuangbiao
Published: January 2023

By combining HTE and machine learning technologies, an iridium(i)-catalyzed highly selective O–H bond insertion reaction of carboxylic acids and sulfoxonium ylides was developed, and an extensive reaction space exploration was accomplished.
A new fluorescent probe for sensing Al3+ ions in the solution phase and CH3COO− in the solid state with aggregation induced emission (AIE) activity
Authors: Bhowmick Rahul , Mondal Payel , Chattopadhyay Pabitra
Published: January 2023

A new luminophore performs as an AIE active fluorescent probe for Al3+ ion sensing in the solution phase and CH3COO− in the solid state.
Zinc-mediated carboxylations of allylic and propargylic halides in flow: synthesis of β-lactones via subsequent bromolactonization
Authors: Sutter Patrick J. , Kang Guowei , Vellalath Sreekumar , Romo Daniel
Published: January 2023

Zinc-mediated carboxylation of allylic halides under flow conditions delivered β,γ-unsaturated carboxylic acids and subsequent bromolactonization provides a streamlined process for the synthesis of γ-bromo-β-lactones.
Activation of perfluoroalkyl iodides by anions: extending the scope of halogen bond activation to C(sp3)–H amidation, C(sp2)–H iodination, and perfluoroalkylation reactions
Authors: Wang Yaxin , Cao Zehui , He Qin , Huang Xin , Liu Jiaxi , Neumann Helfried , Chen Gong , Beller Matthias
Published: January 2023

A simple activation of perfluoroalkyl iodides by tBuONa or KOH allows the promotion of α-sp3 C–H amidation reactions of alkyl ethers and benzylic hydrocarbons, C–H iodination of heteroaryl compounds, and perfluoroalkylations of electron-rich π bonds.
Donor engineering of diphenylamine-substituted tris(2,4,6-trichlorophenyl)methyl radicals for controlling the intramolecular charge transfer and near-infrared photothermal conversion
Authors: Yan Chuan , Fang Jing , Zhu Jiangyu , Chen Weinan , Wang Min , Chi Kai , Lu Xuefeng , Zhou Gang , Liu Yunqi
Published: January 2023

Donor engineering of diphenylamine-substituted tris(2,4,6-trichlorophenyl)methyl (TTM) radicals triggers the switching of the TTM-based radicals from the photoluminescent to NIR photothermal mode.
Combining negative photoconductivity and resistive switching towards in-memory logic operations
Authors: Paramanik Subham , Pal Amlan J.
Published: January 2023

We demonstrate that a material exhibiting a negative photoconductivity and resistive switching can manifest in-memory OR logic gate operations. We have considered devices based on silver-bismuth-iodide rudorffites for this function.
Self-assembly and salt-induced thermoresponsive properties of amphiphilic PEG/cation random terpolymers in water
Authors: Kanno Rikuto , Ouchi Makoto , Terashima Takaya
Published: January 2023

Herein, we report the self-assembly and salt-induced thermoresponsive properties of amphiphilic random terpolymers consisting of hydrophilic poly(ethylene glycol) (PEG) and quaternary ammonium cations, and hydrophobic dodecyl groups in water.
Analysis and weakening of radial electromagnetic forces in high‐speed permanent magnet motors with external rotors based on shape functions
Authors: Teng XiaoYuan , Li Yan , Zhang BingYi , Feng GuiHong , Liu ZeYu
Published: January 2023

In this paper, a strategy of integrating direct‐drive turbine compressors with high‐speed permanent magnet external rotor motors is used to improve the problems of large footprint, low efficiency and high maintenance costs. The rotor of the motor will vibrate under the action of radial electromagnetic force when rotating, and under the action of high pressure and high speed gas, it may aggravate the rotor vibration. In the case of changing the original mechanical structure of the turbine, the vibration of the motor rotor needs to be analysed. In the paper, the radial electromagnetic force applied to the rotor is analysed. The influence of the order and size of the stator and rotor magnetic field harmonics on the size, frequency and order of the radial electromagnetic force wave is summarised. In order to weaken the radial electromagnetic force, this paper proposes a shape function about the magnetic pole size and designs a magnetic pole accordingly. The validity of the shape function was confirmed by comparing the radial electromagnetic force wave with a conventional, surface‐mounted, built‐in magnetic pole structure. Finally, based on the analysis of the rotor dynamics mode, the law of the effect of the change of the pole arc coefficient of the pole on the radial force was analysed using harmonic response, and reasonable conclusions were drawn.
Optimal operation of basin‐based tidal units equipped with hydro‐pumps
Authors: Negahdari Mohammad Reza , Ghaedi Amir , Nafar Mehdi , Simab Mohsen
Published: January 2023

Due to their clean nature, high capacity and accurate predictability, the basin‐based tidal units can be integrated into bulk power systems. The major problem of these units is the high investment cost of barrage construction, and so, among different renewable resources, these units are less developed. For making the tidal barrages cost‐effective, new methods should be implemented to increase their produced power that results in the reduction of electricity price. For this purpose, this study suggests new techniques for optimally operating tidal units equipped with hydro pumps. Here, to increase the produced power and energy of the tidal units, at each time, the number of turbines, sluices and hydro‐pumps is optimally determined to yield the maximum produced energy of the generation unit using the particle swarm optimization method. For satisfying the effectiveness of the suggested approach, the optimal operation of a tidal unit installed on the estuary of Bacanga is done and the impact of optimal dispatching of the turbines, sluices and hydro‐pumps on produced energy of the unit is studied. It is deduced from numerical results that the generated energy of the plant during 24 h is increased by 17% with the implementation of the proposed operation plan.
Quantitative spectroscopy of late O-type main-sequence stars with a hybrid non-LTE method
Authors: Aschenbrenner P. , Przybilla N. , Butler K.
Published: January 2023

Context. Late O-type stars at luminosities log L/L⊙ ≲ 5.2 show weak winds with mass-loss rates lower than 10−8 M⊙ yr−1. This implies that, unlike their more massive and more luminous siblings, their photospheric layers are not strongly affected by the stellar wind.

Aims. A hybrid non-local thermodynamic equilibrium (non-LTE) approach – line-blanketed hydrostatic model atmospheres computed under the assumption of LTE in combination with non-LTE line-formation calculations – is tested for analyses of late O-type stars with masses up to ~25 M⊙. A sample of 20 mostly sharp-lined Galactic O stars of spectral types O8 to O9.7 and luminosity classes V and IV, previously studied in the literature using full non-LTE model atmospheres, is investigated.

Methods. Hydrostatic and plane-parallel atmospheric structures and synthetic spectra computed with Kurucz’s ATLAS12 code together with the non-LTE line-formation codes DETAIL and SURFACE, which account for the effects of turbulent pressure on the atmosphere, were employed. High-resolution spectra were analysed for atmospheric parameters using hydrogen lines, multiple ionisation equilibria, and elemental abundances. Fundamental stellar parameters were derived by considering stellar evolution tracks and Gaia Early Data Release 3 (EDR3) parallaxes. Interstellar reddening was characterised by fitting spectral energy distributions from the UV to the mid-IR.

Results. A high precision and accuracy is achieved for all derived parameters for 16 sample stars (4 objects show composite spectra). Turbulent pressure effects turn out to be significant for the quantitative analysis. Effective temperatures are determined to 1–3% uncertainty levels, surface gravities to 0.05 to 0.10 dex, masses to better than 8%, radii to better than 10%, and luminosities to better than 20% uncertainty typically. Abundances for C, N, O, Ne, Mg, Al, and Si are derived with uncertainties of 0.05–0.10 dex and for helium within 0.03–0.05 dex (1σ standard deviations) in general. Overall, results from previous studies using unified photosphere plus wind (full) non-LTE model atmospheres are reproduced, and with higher precision. The improvements are most pronounced for elemental abundances, and smaller microturbulent velocities are found. An overall good agreement is found between our spectroscopic distances and those from Gaia. Gaia EDR3-based distances to the Lac OB1b association and to the open clusters NGC 2244, IC 1805, NGC 457, and IC 1396 are determined as a byproduct. The derived N/C versus N/O abundance ratios tightly follow the predictions from stellar evolution models. Two ON stars show a very high degree of mixing of CNO-processed material and appear to stem from binary evolution.
Early lingual nerve suture under local anesthesia after wisdom tooth extraction: a case report
Authors: Godard Aurélien , Millot Gaël
Published: January 2023

Introduction: Lingual nerve injury is one of the operative risks of mandibular wisdom tooth avulsion surgery. The anatomical relationship of the nerve to the medial side of the socket of the mandibular third molar must be known when performing the procedure. When a lesion occurs, the diagnosis may be delayed by the effect of anesthesia. In the case of a complete section, repair can be considered by direct suture of the nerve margins. It is recommended to perform this suture as soon as possible. In most cases, the lingual nerve suture is performed remotely and under general anesthesia. Observation: The case presented here describes the early repair of a lingual nerve transection after avulsion of a mandibular third molar. The procedure has been performed under local anesthesia one day after surgery and consisted of a direct suture using the previous surgical approach. Conclusion: This allows for a simplified treatment of this complication, thus shortening the management time.
Les enjeux éthiques du suivi à long terme des cancers pédiatriques
Authors: Camus Agathe , Henry Julie
Published: January 2023

Les avancées en termes de traitement des cancers pédiatriques permettent aujourd’hui de guérir plus de 80 % des enfants atteints, leur ouvrant la perspective d’un retour à une « vie normale » après une période plus ou moins longue marquée par les traitements curatifs et des hospitalisations à répétition. L’idée de « vie normale », cependant, prend un sens particulier chez les personnes qui ont vécu le cancer dans l’enfance et qui sont à risque de développer des séquelles en lien avec les traitements qu’elles ont reçus. Bien loin de toujours consister dans la fermeture d’une parenthèse, celle de l’épisode du cancer, et le retour à une forme de stabilité, la reprise d’une « vie normale » doit composer avec de nombreuses incertitudes et repose sur un équilibre que l’incitation à reprendre un suivi médical « de surveillance » à long terme vient parfois perturber.
Des pistes de réflexion sur les enjeux éthiques de l’accompagnement et de la reconnaissance de l’autonomie des mineurs transgenres en France
Authors: Remaud Émilie
Published: January 2023

Alors que le nombre d’enfants et d’adolescents exprimant une transidentité a augmenté ces dernières années, une controverse sociétale est apparue sur l’approche thérapeutique et les options médicales appropriées. L’accompagnement des mineurs transgenres pose des questions éthiques auxquelles il convient d’apporter des pistes de réflexion, en particulier sur les enjeux de la reconnaissance de l’autonomie de ces jeunes dans les processus de consentement et de prise de décision.
Enjeux éthiques de l’accompagnement des enfants et des adolescents et adolescentes trans ou en questionnement : articulation à la santé reproductive
Authors: Mendes Nicolas , Woestlandt Laure , Moreau Clément , Eustache Florence , Condat Agnès
Published: January 2023

L’accompagnement des enfants et des adolescents et adolescentes trans ou en questionnement ne peut faire l’économie d’une pensée éthique réflexive de sa propre pratique en tant que professionnel de santé. Il est important de considérer le jeune dans sa globalité, et cela également en ce qui concerne les enjeux en santé reproductive. Cet article propose, au travers des principes de Tom Beauchamps et James Childress, une réflexion éthique des enjeux de bienfaisance/non nuisance, d’autonomie et de justice, pour les adolescents, jeunes adultes, et futurs parents trans ou en questionnement. Pour les adolescents et les adolescentes, autour des possibilités de traitement médical d’affirmation de genre, il est nécessaire de proposer des informations, en termes d’impact sur la fertilité et, le cas échéant, des propositions de possibilités de conservation de ses capacités reproductives. Ces enjeux nécessitent d’interroger l’état des connaissances scientifiques en termes de parentalité des personnes trans et en questionnement. Nous proposons ici un état des lieux des connaissances de ces réalités, mises en perspective des axes de réflexions éthiques inhérentes aux accompagnements. In fine, il apparaît que l’enjeu éthique majeur porte sur l’enfant à naître. À cela, il est nécessaire de considérer la qualité de vie des futurs parents et l’impact des accompagnements médicaux des personnes.
Lost in Transition – Eine explorative qualitative Studie zur Transition von Jugendlichen aus der pädiatrischen Physiotherapie in die Erwachsenenphysiotherapie
Authors: Cott Rachel , Holtz Sepp , Scheermesser Mandy
Published: January 2023

Hintergrund In der Kinderphysiotherapie werden Kinder mit komplexer Beeinträchtigung oder chronischer Erkrankung und ihre Familien über Jahre begleitet. Während der Transition eines Jugendlichen in das Erwachsenenleben stellt sich oft die Frage: Wie kann sichergestellt werden, dass die Transition eines Jugendlichen von der pädiatrischen Physiotherapie in die Erwachsenenphysiotherapie als fließender Prozess ablaufen kann?

Ziel Evaluation von fördernden und hemmenden Faktoren für eine fließende Transition in der Physiotherapie sowie das Erstellen eines Leitfadens, um den Transitionsprozess fließender zu gestalten.

Methode In der qualitativen Studie wurden Beteiligte (Jugendliche, Eltern, Physiotherapeut*innen) mit leitfadengestützten Interviews befragt. Die Interviews wurden mittels der inhaltlich strukturierenden Inhaltsanalyse analysiert. Fördernde und hemmende Faktoren wurden abgeleitet.

Ergebnisse Es wurden 3 Hauptkategorien mit je 2 Subkategorien herausgearbeitet: 1. Eine vertrauensvolle und langjährige Beziehung zwischen allen Beteiligten spielt eine zentrale Rolle, 2. Um die Besonderheiten von Jugendlichen aufzuzeigen, sind medizinische und persönliche Informationen unerlässlich, 3. Das fachliche Wissen der Physiotherapeut*innen kann auf Erfahrung beruhen, aber genauso wichtig sind die Freude und das Interesse, sich weiterzubilden. Allen Beteiligten ist klar, dass eine optimale Übergabe eine zeitaufwändige und intensive Arbeit ist. Die Beziehung zwischen den verschiedenen Personen ist dabei das Kernelement.

Schlussfolgerung Für den Übergang von einer kindzentrierten zu einer erwachsenenorientierten Physiotherapie ist es wichtig, alle Beteiligten für das Thema zu sensibilisieren und alle wichtigen Teilschritte, die dieser Prozess beinhaltet, zu berücksichtigen. Ein Leitfaden zur Transition sollte den Prozess erleichtern.
Exercise Changes Gut Microbiota: A New Idea to Explain that Exercise
Improves Autism
Authors: Xue Yaqi , An Shasha , Qiu Weihua , Zhang Weinan , Fu Limin , Zhen Zhiping
Published: January 2023

The effect of exercise interventions on autism spectrum disorder (ASD) has been
demonstrated in many studies, and the discovery of a bidirectional relationship
between the gut microbiome (GM) and the central nervous system (CNS) has led to
the concept of the microbial gut-brain axis (MGBA) and has linked the abnormal
GM to a variety of neuropsychiatric disorders, autism being one of them.
Research on improving the GM through exercise is also starting to come into
focus. However, there are currently few studies on exercise intervention in the
GM of autism. The purpose of this review was to find evidence to explore the
possible potential effects of exercise to improve the behavior of individuals
with autism in the MGBA in this treatment, as well as the potential of GM as an
exercise treatment for autism. We will explore (1) changes in GM components of
ASD and their relationship to the pathophysiology of ASD; (2) the relationship
between exercise and changes in GM components, and (3) the effect of exercise on
GM in CNS disorders. Ultimately, we concluded that Streptococcus,
Bifidobacterium, Clostridium, Bacteroides, and
Blautia may be potential effectors through the MGBA network during
exercise to ameliorate ASD targeting microbiotas. They deserve high attention in
the follow-up studies.
Imaging Recommendations for Diagnosis, Staging and Management of Larynx and Hypopharynx Cancer
Authors: Sahu Arpita , Mahajan Abhishek , Palsetia Delnaz , Vaish Richa , Laskar Sarbani Ghosh , Kumar Jyoti , Kamath Namita , Bhalla Ashu Seith , Shah Diva , Sahu Amit , Agarwal Ujjwal , Venkatesh Aditi , Ankathi Suman Kumar , Janu Amit , Patil Vasundhara , Kapadia Tejas H. , Bal Munita , Sinha Shwetabh , Prabhash Kumar , Dcruz A. K.
Published: January 2023

We discussed the imaging recommendations for diagnosis, staging, and management of larynx and hypopharynx cancer. Carcinoma of the larynx is a common cancer, with males being affected more. Hypopharyngeal carcinoma is less common than laryngeal malignancies. Squamous cell carcinoma is the most common histological type. Nonsquamous cell malignant lesions are rare and mostly submucosal lesions. Clinical examination and endoscopy play an integral role in its detection and staging. Imaging also plays a major role in its staging, including local disease extent, nodal and distant metastatic status, as well as to assess response to therapy. Follow-up of treated cases and differentiation of recurrence from post treatment changes can be done on imaging. Early stage disease is treated with single modalities such as radiotherapy or surgery. Advanced disease is treated with multimodality of either chemoradiotherapy or surgery followed by adjuvant radiotherapy with or without concurrent chemotherapy.
Hypercalcemia in Chronic Myeloid Leukemia: An Unusual Presentation
Authors: Agarwal Khushboo , Gupta Naveen , Malhotra Hemant
Published: January 2023

Hypercalcemia in CML is an unusual paraneoplastic syndrome and is associated with worse prognosis and reduced survival. It usually seen in blast crisis or accelerated phase but can also indicate bony infiltration by cancer cells. Multiple mechanisms can be involved in a patient. We present a case of hypercalcemia in CML in chronic phase without bony infiltration or increased parathormone levels. Increased calcium levels may also be first indication of tyrosine kinase inhibitor resistance. Patient was managed symptomatically with subsequent change of the drug for managing CML. He is currently stable at six months follow-up. Therefore, careful evaluation of the cause of hypercalcemia is necessary for appropriate management.
Imaging Recommendations for Diagnosis, Staging, and Management of Lung Cancer
Authors: Irodi Aparna , Bhalla Ashu Seith , Robinson Vimala Leena , Yadav Taruna , Adithan Subathra , Bhujade Harish , Sanghavi Parang , Kale Alok , Garg Mandeep , Mahajan Abhishek , Jaykar David Livingstone Yvette Kirubha , Das Sudha Kiran , H. Geethi M. , Sasidharan Balukrishna , Thangakunam Balamugesh , Pavamani Simon , Isiah Rajesh , Joel Anjana , Bhat Tameem Ahmad
Published: January 2023

Globally and in India, lung cancer is one of the leading malignancies in terms of incidence and mortality. Smoking and environmental pollution are the common risk factors for developing lung cancer. Traditionally, lung cancer is divided into small cell and nonsmall cell types, with nonsmall cell carcinomas including squamous cell carcinoma, adenocarcinoma, and large cell carcinoma.

In this review article, we describe the imaging recommendations and findings in the diagnosis, staging, and management of lung cancer, including the imaging of treatment-related complications.
Application of Stichopus hermanni Nanoparticle Gel in the Healing of Traumatic Ulcers
Authors: Sari Rima Parwati , Larashati Debora Intan Dewi , Aldiana Clarissa , Nafi'ah Nafi'ah , Damaiyanti Dian Widya , Kurniawati Atik
Published: January 2023

Objective The aim of this research was to investigate the use of Stichopus herrmanni nanoparticle gel on the ulcer healing process by observing blood vessels, fibroblasts, and Collagen type-I (COL-1) expression on the 4 and 7th days after trauma.

Materials and Methods Gold sea cucumber (Stichopus herrmanni) powder was processed by freeze-drying method, then by high-energy milling to form nanoparticle size, and then with CMC 2% to make hydrogel. Traumatic ulcers were formed by induction using a burner. Five groups of male Wistar rats, each consisting of six tails, were divided into a negative control group that was given a placebo, the positive control group was given 0.2% hyaluronic acid, and the treatment group was given gold sea cucumbers with concentrations of 0.135, 0.27, and 0.54% (SH1-SH2-SH3). Fibroblast and blood vessels were examined with hematoxylin-eosin on day 3 and 7, while COL-1 expression was examined with immunohistochemistry on day 7. The rats' mucosa was taken on the 3rd and 7th days after the traumatic ulcer was formed.

Statistical Analysis The data were analyzed using a one-way analysis of variance followed by a post-hoc test with a p less than 0.05.

Results Nanoparticles gel freeze-drying of Stichopus herrmanni increased blood vessels on day 3. Angiogenesis continued to occur, which resulted in increased fibroblast and COL-1 expression on day 7.

Conclusions The application of Stichopus herrmanni nanoparticle gel at 0.27% effectively increased the number of blood vessels, fibroblasts, and COL-1 expression in healing traumatic ulcers.
Early Discharge of Newborns Born to Mothers with COVID-19: A Possible Safe Strategy
Authors: Costa Simonetta , Coppola Maria , Fattore Simona , Tana Milena , Gassino Lisa , Catalano Paola , Pastorino Roberta , Vento Giovanni
Published: January 2023

Objective In this study, we evaluated the safety of early discharge (ED) of newborns born to coronavirus disease 2019 (COVID-19)-positive mothers.

Study Design All ED newborns from the postpartum wards of the Fondazione Policlinico Gemelli between January 1, 2022, and February 28, 2022, were retrospectively analyzed. Newborns from mothers with COVID-19 and those from uninfected mothers were considered. The primary outcome was to evaluate whether the rate of the composite outcome, which was the percentage of rehospitalization/access in emergency room (RH/ER) within the first week from discharge, differed between neonates born to mother with COVID-19 (COVID-19 group) and those born to uninfected mothers (no COVID-19 group). The secondary outcomes were to assess the quality of feeding and number of outpatient visits in the follow-up clinic between the two cohorts of patients.

Results One hundred and thirty-four newborns in the no COVID-19 group and 26 in the COVID-19 group were analyzed. The rate of RH/ER in the no COVID-19 group was of 6 over 134 newborns (0.045, 95% confidence image [CI]: 0.017–0.095), while in COVID-19 group, it was of 2 over 26 newborns (0.077), which does not differ from the expected rate (1.17 over 26 newborns, 0.045, 95% CI: 0.017–0.095).

Conclusion ED for newborns from mothers with COVID-19 could be an actionable safe strategy.

Key Points
Comparison of Canine Forelimb Kinematic Joint Angles Collected with 2D and 3D Models
Authors: Sandberg Gabriella S. , Torres Bryan T. , Budsberg Steven C.
Published: January 2023

Objective The aim of this study was to compare a Joint Coordinate System (JCS) three-dimensional (3D) kinematic model of the canine forelimb with more widely used linear (LIN) and segmental (SEG) 2D models.

Study Design It was an in vivo biomechanical study.

Animals Normal adult mixed breed dogs were used in this study (n = 6).

Methods Nineteen retroreflective markers were applied to the skin of dogs' right forelimbs. Dogs were trotted and walked through the calibrated testing space. The first five good trials were used to generate sagittal plane (flexion and extension angle) waveforms from 3 different models (JCS, LIN and SEG) for the shoulder, elbow and carpal joints. The JCS model also generated transverse and frontal plane joint angular data (internal/external and abduction/adduction angles) for all three joints. Minimum, maximum and total angular displacement was calculated for each joint. Comparison of sagittal plane waveforms was performed before and after waveform alignment using statistical parametric mapping.

Results Each model produced similar sagittal plane waveforms, though the LIN model had a greater vertical shift along the y-axis for the shoulder and elbow. Before waveform alignment, differences were revealed between the LIN model when compared to JCS or SEG model at a trot. No differences were revealed at a walk. After waveform alignment, no differences were revealed between models at a walk or trot. There were no differences in angular displacement measurements between models before or after waveform alignment at a walk or trot.

Conclusions The 3D JCS model reported in this study produced sagittal plane waveforms comparable to conventional 2D models while also providing joint specific information from other planes of motion.
Derek Jarman’s medieval blood: Queer devotion, affective medicine, and the AIDS Crisis
Authors: Myerson Eleanor
Published: January 2023

In this article I consider medieval blood imagery in the paintings, films and journals of Derek Jarman, focusing on works made between 1989–1993. Taking a transhistorical comparative approach, I analyse Jarman's images alongside his medieval sources, primarily Julian of Norwich's Revelations and Gerard of Cremona's translation of Ibn Sīnā's (Avicenna's) al-Qa'n ū n fī al-tibb (Canon of Medicine). In addition, I find my own commonalities between Jarman and the medieval, for example, juxtaposing his Queer series of paintings with MS Egerton 1821. Critics have explored the medieval as a site of historical precedent for the stigmatisation of disease, providing a reservoir of images of leprosy and plague which inform the discourse of AIDS as immoral pollution. However I follow Jarman's lead in seeking new avenues through the medieval in relation to the AIDS crisis. Refusing to accept the discourses which cast his HIV+ blood as the ultimate symbol of pollution and death, Jarman mobilised the aesthetics and imagery of medieval affective devotion as a powerful alternative. Through the deployment of these traditions, HIV+ blood becomes holy blood, the source of salvation, desire, community and healing.
Analysis of the ionic and dielectric properties of perovskites by impedance spectroscopy
Authors: Xu Cong , Alvar Mohammad Sajedi , Wetzelaer Gert-Jan A. H. , Blom Paul W. M.
Published: January 2023

For understanding the operation of perovskite solar cells and light-emitting diodes, knowledge of the dielectric properties is indispensable. The dielectric properties of perovskites are frequency dependent due to the presence of moving ions, which complicates the interpretation of impedance spectra. Using Au/CsPbI2Br/Au capacitors with varied layer thickness as a model system, we demonstrate that in the dark, an extended Maxwell circuit consistently describes the impedance data. From the thickness dependence of the resistivities, both the electronic and ionic conductivities are obtained, whereas the combination of electronic and ionic capacitances with the characteristic frequencies for space-charge formation determines the ion diffusion coefficient and ion density. At low frequencies, a slow transient process with a fixed time constant of ∼0.1 s occurs, governed by the electronic conductivity, being independent of illumination strength and sample thickness. As a possible mechanism, we propose the spatial reorganization of ions within the ion accumulation layer at the electrode/perovskite interface.
Collective lattice and plasmonic resonances in the enhancement of circular dichroism in disk–rod metasurface
Authors: Romashkina A. M. , Novikov V. B. , Murzina T. V.
Published: January 2023

Compact planar photonic elements serving for efficient control over the polarization of light are of paramount importance in photonics. Here, we propose a design of a chiral periodic metasurface based on plasmonic nanodisks and nanorods arranged asymmetrically in a unit cell. Using the finite-difference time-domain analysis, we show that the collective lattice resonance harnessed by the diffraction coupling of the plasmonic unit cells is the heart of the revealed resonant 38% circular dichroism effect. The circular dichroism enhancement of the considered structure is improved using the deep-learning-assisted optimization of the metasurface design.
Accounting for the ultraviolet divergence in field-theoretic simulations of block copolymer melts
Authors: Matsen M. W. , Beardsley T. M. , Willis J. D.
Published: January 2023

This study examines the ultraviolet (UV) divergence in field-theoretic simulations (FTSs) of block copolymer melts, which causes an unphysical dependence on the grid resolution, Δ, used to represent the fields. Our FTSs use the discrete Gaussian–chain model and a partial saddle-point approximation to enforce incompressibility. Previous work has demonstrated that the UV divergence can be accounted for by defining an effective interaction parameter, χ=z∞χb+c2χb2+c3χb3+⋯, in terms of the bare interaction parameter, χb, used in the FTSs, where the coefficients of the expansion are determined by a Morse calibration. However, the need to use different grid resolutions for different ordered phases generally restricts the calibration to the linear approximation, χ ≈ z∞χb, and prevents the calculation of order–order transitions. Here, we resolve these two issues by showing how the nonlinear calibration can be translated between different grids and how the UV divergence can be removed from free energy calculations. By doing so, we confirm previous observations from particle-based simulations. In particular, we show that the free energy closely matches self-consistent field theory (SCFT) predictions, even in the region where fluctuations disorder the periodic morphologies, and similarly, the periods of the ordered phases match SCFT predictions, provided the SCFT is evaluated with the nonlinear χ.
Effects of surface roughness on two-degree-of-freedom vortex-induced vibration of a circular cylinder in oscillatory flow
Authors: Jiang Zecheng , Gao Yun , Fu Shixiao , Chai Shenglin , Shi Chen
Published: January 2023

The vortex-induced vibration (VIV) response performances of a two-degree-of-freedom circular cylinder with different surface roughnesses were numerically investigated in this work. Four typical roughnesses values of 1 × 10−4, 5 × 10−3, 1 × 10−2, and 2 × 10−2 were examined for the range of the reduced velocity (Vr = 1–20). The VIV response characteristics including the vibration amplitude, vibration frequency, VIV trajectory, vortex shedding flowing pattern, and hydrodynamic force for different rough cylinders were systematically compared. The numerical results showed that the VIV response of roughness cylinder experiences five evolutions as Vr increases, including five typical X–Y trajectories: centrosymmetry, “M” or “W,” “dough twists” or “candy,” “∞,” and asymmetrical ∞, exhibiting three vortex shedding flow pattern: S mode, C + S mode, and SS mode (a pair of symmetric vortices along the x-axis) under certain conditions. The VIV response was sensitive to the roughness in regime IV and regime V. Furthermore, the normalized vibration frequency of the rough cylinder was an integer multiple of the oscillatory flow frequency, except for the Vr ranged from 6 to 7. The vibration frequency in in-line (IL) direction was consistent with the frequency of the oscillatory flow, which was immune to the change of roughness. Additionally, when roughness was equal to 2 × 10−2, the reduction of maximum vibration amplitude in the cross-flow direction reached 31.2%, comparing with smooth cylinder, whereas the maximum vibration amplitude in the IL direction increased only by 6.2%.
Effects of inlet junctions on horizontally stratified flows
Authors: Heravi Pooyan , Chu Li-An , Yao Da-Jeng
Published: January 2023

Horizontally stratified flows can be seen in a wide variety of micro-scale engineering problems. Recent studies have shown that diffusion at the interface between two liquids leads to a lateral flow, causing the fluid to rotate around the central axis of the channel. This lateral flow has the potential to disrupt the intended mechanism of the device or can be exploited for new device designs. The present investigation presents numerical and experimental results that provide important insights into the effects of the inlet junction on the flow field throughout the microfluidic device. The effects of four different archetypal inlet junctions—an idealized single inlet, counter-flow T junction, perpendicular flow T junction, and Y junction are considered. The results show that counter-flow T junction results in the least amount of lateral flow, while the straight channel results in the highest. The Y channel induces the second least rotation, and the perpendicular T junction creates slightly stronger lateral flows. Furthermore, based on lateral streamlines, it is suggested that the reason for the difference between these junctions can be explained by the interaction of the Dean vortices formed by the rotation of the fluid at the junction and the interaction of the Dean flow with the diffusion-induced vortices. To test this hypothesis, a less common junction (Y junction with angles higher than 180°) is modeled and has shown to reduce the lateral flow even further. Understanding the differences between the junctions would allow for more efficient microfluidic designs for various applications.
Health equity for trans and gender-diverse Australians: addressing the inverse care law through the provision of gender-affirming health care in the primary healthcare setting
Authors: Clune Samantha , Collier Janette , Lewis Virginia
Published: January 2023

Background Equitable access to gender-affirming hormone treatment (GAHT) for trans and gender-diverse people has been identified as a key factor in addressing rates of poor health outcomes in the trans and gender-diverse community. In Australia, GAHT is largely delivered via a medical model, and within acute care facilities. Medicalisation and pathologisation of gender-affirming care acts as a significant barrier to access for many trans and gender-diverse individuals. Methods This project incorporated a case study approach using multiple methods to investigate a recent community sponsored, co-designed program providing GAHT that included a peer navigator (PN) model of care in a primary healthcare (community health) setting. Results Service activity in Year 1 and Year 2 demonstrated acceptability of the model, with over 1000 appointments delivered. This was supported by client feedback survey data collected at their initial (n = 110) and then 6-months post visit (n = 78) with the PN, and 31 interviews with clients, staff and stakeholders. Conclusion Findings highlight the integral nature of the PN to the sustainability of the program, with some key insights into potential barriers. Basing service design on an Informed Consent model recognises the agency of the individual and their right to equitable access to health care of their choosing.
LPG stored at the wildland–urban interface: recent events and the effects of jet fires and BLEVE
Authors: Barbosa Thiago Fernandes , Reis Luís , Raposo Jorge , Rodrigues Tiago , Viegas Domingos Xavier
Published: January 2023

Background Jet fires and boiling liquid expanding vapour explosions (BLEVEs) are potential events when a vessel containing liquefied petroleum gas (LPG) is exposed to fire. Events involving domestic LPG tanks have occurred at wildland–urban interface areas in Portugal, the USA, Spain and Greece. Aims Evaluation of the pressure relief device (PRD), the type of cylinder and the effects of jet fires and BLEVEs. Methods LPG cylinders manufactured with steel and composite materials were exposed to fire. Hydrostatic tests were carried out to compare the burst pressure without fire influence. Fourteen accidents that occurred during wildfires are described. Key results The presence of a PRD and the right choice of type of cylinder as well as cylinder location may avert major accidents. The jet fires and fireball radiation are also described, as well as the maximum distance reached by cylinder fragments. Conclusions The tests showed that the burst pressure in the test of a cylinder without PRD under fire was significantly lower when compared with the hydrostatic tests. Implications Lastly, recommendations to avoid accidents are made.
In vivo expression vector derived from anhydrobiotic tardigrade genome enables live imaging in Eutardigrada
Authors: Tanaka Sae , Aoki Kazuhiro , Arakawa Kazuharu
Published: January 2023

Water is essential for life, but anhydrobiotic tardigrades can survive almost complete dehydration. Anhydrobiosis has been a biological enigma for more than a century with respect to how organisms sustain life without water, but the few choices of genetic toolkits available in tardigrade research have been a challenging circumstance. Here, we report the development of an in vivo expression system for tardigrades. This transient transgenic technique is based on a plasmid vector (TardiVec) with promoters that originated from an anhydrobiotic tardigrade
Ramazzottius varieornatus
. It enables the introduction of GFP-fused proteins and genetically encoded indicators such as the Ca
2+
indicator GCaMP into tardigrade cells; consequently, the dynamics of proteins and cells in tardigrades may be observed by fluorescence live imaging. This system is applicable for several tardigrades in the class Eutardigrada: the promoters of anhydrobiosis-related genes showed tissue-specific expression in this work. Surprisingly, promoters functioned similarly between multiple species, even for species with different modes of expression of anhydrobiosis-related genes, such as
Hypsibius exemplaris,
in which these genes are highly induced upon facing desiccation, and
Thulinius ruffoi
, which lacks anhydrobiotic capability. These results suggest that the highly dynamic expression changes in desiccation-induced species are regulated in
trans
. Tissue-specific expression of tardigrade-unique unstructured proteins also suggests differing anhydrobiosis machinery depending on the cell types. We believe that tardigrade transgenic technology opens up various experimental possibilities in tardigrade research, especially to explore anhydrobiosis mechanisms.
Faulty TRPM4 channels underlie age-dependent cerebral vascular dysfunction in Gould syndrome
Authors: Yamasaki Evan , Ali Sher , Sanchez Solano Alfredo , Thakore Pratish , Smith Megan , Wang Xiaowei , Labelle-Dumais Cassandre , Gould Douglas B. , Earley Scott
Published: January 2023

Gould syndrome is a rare multisystem disorder resulting from autosomal dominant mutations in the collagen-encoding genes
COL4A1
and
COL4A2.
Human patients and
Col4a1
mutant mice display brain pathology that typifies cerebral small vessel diseases (cSVDs), including white matter hyperintensities, dilated perivascular spaces, lacunar infarcts, microbleeds, and spontaneous intracerebral hemorrhage. The underlying pathogenic mechanisms are unknown. Using the

Col4a1
+/G394V

mouse model, we found that vasoconstriction in response to internal pressure—the vascular myogenic response—is blunted in cerebral arteries from middle-aged (12 mo old) but not young adult (3 mo old) animals, revealing age-dependent cerebral vascular dysfunction. The defect in the myogenic response was associated with a significant decrease in depolarizing cation currents conducted by TRPM4 (transient receptor potential melastatin 4) channels in native cerebral artery smooth muscle cells (SMCs) isolated from mutant mice. The minor membrane phospholipid phosphatidylinositol 4,5 bisphosphate (PIP
2
) is necessary for TRPM4 activity. Dialyzing SMCs with PIP
2
and selective blockade of phosphoinositide 3-kinase (PI3K), an enzyme that converts PIP
2
to phosphatidylinositol (3, 4, 5)-trisphosphate (PIP
3
), restored TRPM4 currents. Acute inhibition of PI3K activity and blockade of transforming growth factor-beta (TGF-β) receptors also rescued the myogenic response, suggesting that hyperactivity of TGF-β signaling pathways stimulates PI3K to deplete PIP
2
and impair TRPM4 channels. We conclude that age-related cerebral vascular dysfunction in

Col4a1
+/G394V

mice is caused by the loss of depolarizing TRPM4 currents due to PIP
2
depletion, revealing an age-dependent mechanism of cSVD.
Self-Determination theory and tasks
Authors: Leeming Paul , Harris Justin
Published: January 2023

Researchers investigating TBLT have used psycholinguistic and sociolinguistic theories in support of the approach,
but there has been limited discussion of motivational frameworks. A framework for motivation within TBLT would enhance our
understanding of learner motivation, and could be utilised in future studies. This paper
argues that Self-Determination Theory is an appropriate framework. After briefly describing the key tenets of TBLT and SDT, the
paper shows how SDT helps us understand the motivational benefits of tasks. It outlines the six mini-theories of SDT, and aligns
them with existing studies to highlight how results may be explained by these theories. Some suggestions are then provided as to
how these theories can be used for conducting future classroom-based research.