bluuebunny/crossref_metadata_2025 huggingface dataset:
Surfactants and Colloidal Properties of Ionic Liquids
Authors: Shah Mansoor Ul Hassan , Nazar Masooma , Shah Syed Nasir , Khan Hayat , Moniruzzaman Muhammad
Published: July 2023

The development of surface-active ionic liquids (SAILs) has gained significant interest in recent decades and has successfully replaced the currently utilized conventional surfactants. Due to the amphiphilic character of the SAILs, they have become remarkable surfactants and are particularly important for commercial and field usage. SAILs formed microemulsions and have shown potential in various sectors, including oil recovery and dispersion. The effectiveness of SAILs was measured by their capacity to develop microemulsions. Moreover, it was stated that efficient SAILs could develop a stable microemulsion throughout extended periods at low surfactant concentrations. Similarly, normal ionic liquids (ILs) gained significant attraction as a dispersion medium for colloidal systems as a potential alternative to volatile organic solvents. Colloidal stability is a crucial parameter for evaluating the characteristics and efficacy of colloidal systems. Therefore, the main emphasis is critically discussing the fundamental studies on colloidal stability. Considering the importance and significance of surfactant and colloidal behavior of ILs, this chapter describes these properties by employing recent relevant literature on the topic. The aggregation properties of SAILs alone and the mixed systems of SAILs and conventional surfactants are discussed with their usage in environmental clean-up. Moreover, the colloidal stability of SAILs, as well as the important factors that influence colloidal stability, are discussed in this chapter.
Ionic Liquids in Wastewater Treatments
Authors: Okpara Enyioma C. , Wojuola Olanrewaju B. , Onwudiwe Damian C. , Tshivhase Victor
Published: July 2023

The scarcity of water has motivated diverse research efforts toward developing efficient techniques for the treatment of wastewater for its reuse. The applications of conventional wastewater treatment technologies, such as chemical precipitation, ion exchange, flotation, flocculation and coagulation, membrane filtration, etc., have been identified with diverse limitations. The commonest of them include high investment and operational costs, the formation of toxic by-products and sludge generation. Ionic liquids (ILs) have been used in numerous analytical and industrial extraction processes; however, their potential in the treatment of wastewater is yet to be fully exploited. This chapter, therefore, explores the applications of various ILs in wastewater treatment and proposes their versatility in the deployment of effective, selective, and rapid extraction processes for the removal of diverse water pollutants. However, the application of technologies based on the use of ILs possesses various challenges, which include a choice of an appropriate ionic liquid, high testing requirement for private applications, disposal, the regeneration process of ILs, scalingup of the whole removal of pollutants, and technological applications.
Ionic Liquids In Corrosion Protection
Authors: Verma Chandrabhan , Quadri Taiwo W. , Nnadozie Ebenezer C. , Olasunkanmi Lukman O. , Fayemi Omolola E. , Ebenso Eno E.
Published: July 2023

The utilization of metals and alloys has been on the increase due to rapid technological advancement and industrialization. Nevertheless, these widely used metallic materials are subject to degradation due to exposure to the environment. Several methods have been applied by scientists to address the problem of corrosion. One of the most successful methods to control metallic degradation remains the application of chemical inhibitors. Ionic liquids are renowned organic compounds with high adsorption abilities and exceptional properties which have drawn attention to their use as corrosion inhibitors. In contemporary years, different types of ionic liquids have been reported to showcase their effectiveness in protecting metallic surfaces from corrosive ions. This chapter discusses recent advancements in the utilization of highperformance ionic liquids as eco-friendly inhibitors in different corrosive environments, as documented in literature over the last three years.
Ionic Liquid in Phase Transfer Catalysis
Authors: Assad Humira , Fatma Ishrat , Kumar Ashish
Published: July 2023

Ionic liquids (ILs) are environmentally friendly solvents and catalysts that are made up of ions that melt at temperatures below 100 degrees Celsius. Due to their favorable features, they were used in a broad range of reactions. A phase-transfer catalyst (PTC) is a type of heterogeneous catalysis that involves chemical reactions that occur when a reactant migrates from one phase to another where a reaction can proceed. High reaction specificity and transformations can be made easier with PTC reactions. PTC has been used in oxidations, alkylation, nucleophilic replacements, polymerizations, reductions, and other processes. In recent years, scientists have become more interested in employing ILs instead of traditional PTCs in biphasic reactions. Their cation architecture and chain length changes have been shown to have a substantial impact on their performance as PTCs. This chapter aims to discuss the role of ILs as phase transfer catalysis in organic synthesis.
Ionic Liquid-Based Electrolyte for Application in Photoelectrochemical cells: A Future Insight
Authors: Sahu Swati , Tiwari Sanjay
Published: July 2023

In this chapter, a series of asymmetric and symmetric ionic liquids (ILs) and IL-modified materials were considered for their versatile application as electrolytes and redox mediators in Photoelectrochemical (PEC) cells. Dye-sensitized solar cells (DSSCs) are PEC cells and third-generation photovoltaic (PV) cells that convert solar PV energy into electrical energy. They have piqued the interest of researchers worldwide due to their simple cell fabrication methods under ambient conditions, as well as their enormous commercialization potential due to their low cost; additionally, the benefits of colorfulness, probable plasticity and high power conversion efficiency (PCE) under indoor irradiation make PEC cells appealing. To attain a high PCE of cells, an organic solvent has to be included with the formulation of the redox mediator in the electrolyte. However, organic solvents are prone to evaporation and leakage. Consequently, PEC cells’ durability is reduced because of the chemical and thermal instability of the redox mediator in the electrolyte. The purpose of including ionic liquids into the redox mediator in the electrolyte was to solve the above-mentioned issue and to allow the PEC cells to act as sustainable energy cells. The chapter describes the integration of ionic liquids into the redox mediator in the electrolyte formulation and evaluates the impact of ionic liquids on the PCE of the cell in various electrolyte conditions.
Despertando em novas terras: imigrantes portugueses e suas articulações locais e transnacionais na construção do anarquismo no Brasil (1899-1920)
Authors: Santos Kauan Willian dos
Published: July 2023

This article aims to analyze the influence of Portuguese immigrants, as well as their political and social networks, in the construction of anarchism in Brazil since its establishment until the 1920s. militants in the Portuguese community of the Brazilianlabor movement, as well as in revolutionary syndicalism and among anarchists: Joaquim Mota Assunção, Neno Vasco and Tércio Miranda. We hypothesize that Portuguese linguistic and cultural elements favored the construction of organizations that united Portuguese immigrants at first, but this did not exclude efforts for unions with the traditions of local struggles and also with other foreigners. This tendency was influenced by the ideologies gestated by the internationalist tradition and also by the transnationalist practice of the Portuguese agents or their descendants, building common class spaces between different countries.
“Meu caro João Cabral de Melo Neto” – Algumas cartas portuguesas
Authors: Cardeal Rafaela
Published: July 2023

A conhecida aversão de João Cabral de Melo Neto à epistolografia, como atestou Murilo Mendes em carta de 29 de outubro de 1960, não impediu completamente sua adesão ao gênero. No arquivo particular do autor, surpreendentemente encontra-se um expressivo volume de cartas, bilhetes e cartões-postais, que documentam todo o percurso biográfico e literário do poeta e diplomata brasileiro desde os anos 40 até seu desaparecimento, no fim da década de 1990. Desponta desse variado conjunto a correspondência trocada com nomes do século XX português, como Sophia de Mello Breyner Andresen, Alexandre O’Neill, Alberto de Serpa, António Reis, dando-nos a ver não só conversas literárias em torno de seus projetos estéticos e poéticos – ou até da vida íntima –, mas também o processo de recepção da obra cabralina no país. De um ponto de vista privilegiado, os bastidores da cena literária luso-brasileira iluminam aspectos do convívio de João Cabral com poetas, escritores e intelectuais portugueses, entre afinidades e divergências, sem deixar de evidenciar sua posição cimeira no panorama da poesia produzida em língua portuguesa.
Do descontentamento à ação estética: na criação do espetáculo “Eis o Homem”
Authors: Silva José Eduardo
Published: July 2023

Este texto aborda algumas das premissas iniciais e desenvolvimentos conceptuais que decorreram do processo de construção e apresentação do espetáculo “Eis o Homem”. Partindo de materiais de reflexão que foram reunidos, construídos e consultados ao longo das principais fases do processo de criação, este texto procura explicitar possibilidades filosóficas, críticas, políticas e epistemológicas inerentes ao trabalho de criação teatral, assim como contribuir para a discussão corrente acerca de formas adequadas de enquadrar estes objetos estéticos sob o ponto de vista da investigação académica.
The Formulation and Evaluation of Anti-Aging Tamarind Leaf (Tamarindus Indica L.) Extract Cream
Authors: Jannah Arini Miftaqul , Aznam Nurfina
Published: July 2023

This study aims to formulate and evaluate the anti-aging tamarind leaf (Tamarindus Indica L.) extract cream due to the increasing demand for the anti-aging product day by day. In this study, tamarind leaf extract was tested to find out its phytochemicals, antioxidant activity using a 1,1-diphenyl-2-picrylhydrazyl method, and anti-aging activity using a UV spectrophotometer. Anti-aging cream was formulated based on the antioxidant and anti-aging potential of tamarind leaf extract and its evaluation. The cream was formulated with tamarind leaf extract, carboxymethylcellulose, and base cream with different emulsion types (water in oil and oil in water). This study revealed that tamarind leaf extract contains alkaloid, flavonoid, saponin, phenol, and tannin. Tamarind leaf extract also has an antioxidant and an anti-aging activity. The cream evaluation showed that cream with extract concentration at 80 ppm emulsion types W/O and O/W placed in outdoor and indoors were to be stable during 4 weeks of stability studies. The creams still have antioxidant activity, do not experience a significant change in their physical appearance at organoleptic test, homogeny, pH range at 4.5-8, spreadability range at 5-7 cm in weight 0-50 gram, and are not separated during centrifugation test.
Features of the functioning of B-2 lymphocytes in patients with common variable immune deficiency in post-vaccination immunity to SARS-CoV-2
Authors: Sizyakina L. P. , Andreeva I. I. , Kharitonova M. V.
Published: July 2023

Objective: B-2 lymphocytes characteristic of patients with CVID in the process of forming a post-vaccination response to the peptide vaccine against SARS-CoV-2.

   Materials and methods: 10 people with CVID diagnosis were included in the study among a cohort of patients with primary immunodeficiency under the supervision of the Research Institute and the Department of Clinical Immunology and allergology of Rostov State Medical University. For the immunoprophylaxis of COVID-19, a recombinant peptide vaccine was used, which was administered intramuscularly at a dose of 0.5 ml twice with an interval of 21 days. The parameters of the immune system were evaluated before vaccination, then 21 days after the first and second doses and 72 days after the first injection. Phenotypic characteristic of peripheral blood B cells was performed by cytofluoriometry flow method.

   Results: before vaccination,  the number of memory B cells with a phenotypic option of switched and unswitched to antibody synthesis at the patients with CVID was lower than the control parameters of practically healthy donors. 21 days after the administration of the first dose, an increase in un-switched and switched memory B cells, plasma blasts, and a decrease in the proportion of B-regulatory lymphocytes were noted in relation to the initial values. 21 days after the second injection, an increase in the total pool of B-2 lymphocytes, naive B cells, switched memory B cells, plasma blasts were revealed. A month later, this tendency continued.

   Conclusion: in the process of forming a post-vaccination response to the peptide vaccine against SARS-CoV-2 in patients with CVID, a transformation of the subpopulation composition of B lymphocytes was revealed, as well as in the form of an increase in the number of memory B2 lymphocytes.
The role of morphofunctional complexes and somnological signs of the pathogenesis of gestational diabetes mellitus in overweight women
Authors: Botasheva T. L. , Deriglazova O. I. , Lebedenko E. Yu. , Zheleznyakova E. V. , Zavodnov O. P. , Zheltetskaya V. Yu. , Ulkina A. A.
Published: July 2023

Objective: to identify the diabetogenic type of the lateral behavioral profile of asymmetries, which reveals the highest incidence of GDM and obstetric complications in overweight pregnant women and, on its basis, to study the features of the somnological status in women with diabetogenic lateral constitution at the preconception period.

   Materials and methods: the study used special testing (Annette test, sleep quality questionnaire, sleep apnea/hypopnea syndrome questionnaire, sleepiness scale (Epworth)), polysomnographic study.

   Results: based on the results of a questionnaire survey and a polysomnographic study, somnological disorders were identified, expressed in a decrease in the efficiency and quality of sleep, fatigue, perceptible drowsiness in wakefulness, breathing disorders during sleep and other sleep disorders, which contributes to an increased risk of gestational diabetes mellitus mainly in women with an ambidextral lateral phenotype.

   Conclusion: the identified sleep disorders in overweight women in the pregravid period are, on the one hand, the result of hormonal changes against the background of already existing metabolic and vegetative abnormalities in overweight women planning pregnancy, on the other hand, they act as a “trigger” functional disorders both during the manifestation of GDM and during the formation of obstetric complications due to increasing hypoxemia in the maternal body against the background of the “obstructive sleep apnea” syndrome, which contributes to the development of fetal distress.
Comparative assessment of the relationship between mental health and insomnia of medical students, working and non-working as nurses
Authors: Samrkhanova I. I. , Kadyrov R. F. , Efremov I. S. , Abdrakhmanova A. E. , Asadullin A. R.
Published: July 2023

Objective: to compare the severity of the relationship between mental state and insomnia of medical students working and not working as nurses.

   Materials and methods: research methods — sociological, psychometric, statistical. The study was conducted at the Bashkir State Medical University (BSMU) from February to April 2022. Data collection was carried out using Google Forms. Study group №1 — 172 students working as nurses. The proportion of males is 41 % (70/172), females — 59 % (102/172). The average age was 21-23 years. Study group № 1 — 66 non-working students. Among the studied 16.7 % (11/66) men, 83.3 % (55/66) women. The average age is 21-23 years. SCL-90-R (Symptom Check List-90-Revised), Insomnia Severity Index (ISI), Pittsburgh Sleep Quality Index (PSQI) were used as methods. Statistical processing was carried out using Microsoft Excel, STATISTICA 10, Spearman correlation coefficient, U — Mann-whitney test.

   Results: the degree of manifestation of insomnia in the study group № 1 and № 2 positively correlates with both all SCL-90-R scales and second-order indices. when comparing the studied groups, it was found that the mental state of non-working students is more unstable, the quality of sleep is worse.

   Conclusions: the relationship between the mental state and insomniac disorders in medical students, both working as nurses and not working, has been established. we assume that students who do not work as nurses have low adaptive abilities, as a result of which their mental state is accompanied by more pronounced insomniac disorders.
Clinical and biochemical phenotypes in cardiorespiratory comorbidity
Authors: Prokofyeva T. V. , Bashkina O. A. , Polunina O. S. , Sevostyanova I. V. , Gritsenko E. L.
Published: July 2023

Objective: to estimate the incidence of recurrent myocardial infarction, stroke, and mortality in patients with different phenotypes of myocardial infarction against the background of chronic obstructive pulmonary disease.

   Materials and methods: 325 patients with myocardial infarction were examined: 195 patients with infarction against the background of chronic obstructive pulmonary disease and 130 patients without chronic obstructive pulmonary disease. We studied markers of endogenous intoxication: molecules of average mass, hematological indexes of intoxication, blood gas composition, apoptosis, protein peroxidation, lipid and antioxidant protection, inflammation and renal function. Statistical processing of the data was performed using SPSS 26.0 software package.

   Results: A two-stage cluster analysis formed four clusters, which were labeled as «polymarker-retentive», «necrotic-inflammatory», «hypoxic-inflammatory», and a cluster with no endogenous intoxication syndrome. Among patients with myocardial infarction against the background of chronic obstructive pulmonary disease, the hypoxic-inflammatory phenotype prevailed — in 53.3 % of patients. Necrotic-inflammatory phenotype was noted in 8.2 % of patients, hypoxic-inflammatory — in 36.9% of patients, phenotype with the absence of endogenous intoxication syndrome — in 1.5 % of patients. Recurrent myocardial infarction, stroke and mortality constituted the combined endpoint. The highest incidence of the combined endpoint was observed in the polymarker-retentive infarct phenotype — in 37 (55.2 %) patients.

   Conclusion: Vascular life-threatening and fatal events (recurrent myocardial infarction, stroke, death from cardiac causes) during 12-month follow-up are most typical for the polymarker-retentive phenotype. The clinical features of this phenotype were the frequent presence of Q-shaped MI, transmural myocardial damage, and the presence of complications in the acute period. COPD in these patients was characterized by a long course, high smoker's index, mostly 3rd degree bronchoobstruction, and frequent exacerbations. The results of this study allow for a personalized approach to the assessment of the annual prognosis in patients with acute myocardial infarction against COPD.
The Use of Virtual Reality Interventions to Promote Positive Mental Health: Systematic Literature Review
Authors: Li Pira Giorgio , Aquilini Beatrice , Davoli Alessandro , Grandi Silvana , Ruini Chiara
Published: July 2023

Background

A large body of research has documented the efficacy of psychological interventions integrated with virtual reality (VR) therapies in treating psychiatric disorders. However, the concept of positive mental health calls for a 2-fold approach in which both symptoms and positive functioning should be addressed by modern interventions.

Objective

This review aimed to summarize studies that applied VR therapies by embracing the positive mental health perspective.

Methods

A literature search was conducted by entering the following keywords—“virtual reality” AND “intervention” OR “treatment” OR “therapy” AND “mental health” NOT “systematic review or meta-analysis”—and limiting it to “journal article” and the English language. To be included in this review, articles had to present at least one quantitative measure of positive functioning and one quantitative measure of symptoms or distress and had to investigate adult populations, including populations with psychiatric disorders.

Results

A total of 20 articles were included. They described various VR protocols that were applied for the treatment of anxiety disorders (5/20, 25%), depression (2/20, 10%), posttraumatic stress disorder (3/20, 15%), psychosis (3/20, 15%), and stress (7/20, 35%). Most of the studies (13/20, 65%) showed the beneficial effects of VR therapies in improving stress and negative symptoms. However, 35% (7/20) of the studies showed no or a small effect on the various dimensions of positivity, particularly in clinical samples.

Conclusions

VR interventions might be cost-effective and largely scalable, but further research is needed to develop existing VR software and treatments according to the modern positive mental health approach.
Web-Based Tool Designed to Encourage Supplemental Nutrition Assistance Program Use in Urban College Students: Usability Testing Study (Preprint)
Authors: Li Catherine Yan Hei , Platkin Charles , Chin Jonathan , Khan Asia , Bennett Jaleel , Speck Anna , Nielsen Annette , Leung May May
Published: July 2023

BACKGROUND

Food insecurity continues to be a risk for college students in the United States. It is associated with numerous problems, such as chronic health conditions, increased stress and anxiety, and a lower grade point average. After COVID-19, the Supplemental Nutrition Assistance Program (SNAP) benefits were extended to college-aged students; however, there were some barriers to participation, which persisted such as lack of perceived food insecurity risk, lack of knowledge regarding the SNAP application process, the complexity of determining eligibility, and stigma associated with needing social assistance. A technology-enhanced tool was developed to address these barriers to SNAP enrollment and encourage at-risk college students to apply for SNAP.

OBJECTIVE

The purpose of this study was to test the usability and acceptability of a web-based SNAP screening tool designed for college-aged students.

METHODS

College students aged 18-25 years were recruited to participate in 2 rounds of usability testing during fall 2022. Participants tested the prototype of a web-based SNAP screener tool using a standardized think-aloud method. The usability and acceptability of the tool were assessed using a semistructured interview and a 10-item validated System Usability Scale questionnaire. Audio recordings and field notes were systematically reviewed by extracting and sorting feedback as positive or negative comments. System Usability Scale questionnaire data were analyzed using the Wilcoxon signed rank test and sign test.

RESULTS

A total of 12 students (mean age 21.8, SD 2.8 years; n=6, 50% undergraduate; n=11, 92% female; n=7, 58% Hispanic or Black or African American; n=9, 78% low or very low food security) participated in both rounds of user testing. Round 1 testing highlighted overall positive experiences with the tool, with most participants (10/12) stating that the website fulfills its primary objective as a support tool to encourage college students to apply for SNAP. However, issues related to user interface design, navigation, and wording of some questions in the screening tool were noted. Key changes after round 1 reflected these concerns, including improved design of response buttons and tool logo and improved clarity of screening questions. The overall system usability showed slight, but not statistically significant, improvement between round 1 and round 2 (91.25 vs 92.50; P=.10, respectively).

CONCLUSIONS

Overall usability findings suggest that this web-based tool was highly usable and acceptable to urban college students and could be an effective and appealing approach as a support tool to introduce college students to the SNAP application process. The findings from this study will inform further development of the tool, which could eventually be disseminated publicly among various college campuses.
Effect of a Medication Adherence Mobile Phone App on Medically Underserved Patients with Chronic Illness: Preliminary Efficacy Study (Preprint)
Authors: Hartch Christa E , Dietrich Mary S , Stolldorf Deonni P
Published: July 2023

BACKGROUND

Medication adherence is vital in the treatment of patients with chronic illness who require long-term medication therapies to maintain optimal health. Medication adherence, a complex and widespread problem, has been difficult to solve. Additionally, lower-income, medically underserved communities have been found to have higher rates of inadequate adherence to oral medications. Even so, this population has been underrepresented in studies using mobile medication adherence app interventions. Federally qualified health centers provide care for medically underserved populations, defined as communities and populations where there is a demonstrable unmet need for health services. These centers have been reporting an increase in a more complex chronic disease population. Including medically underserved individuals in mobile health studies provides opportunities to support this disproportionately affected group, work toward reducing health disparities in access to health care, and understand barriers to mobile health uptake.

OBJECTIVE

The aim of this preliminary efficacy study was to evaluate the effects and feasibility of a commercially available medication adherence app, Medisafe, in a medically underserved adult population with various chronic illnesses seeking care in a federally qualified health center.

METHODS

Participants in this single-arm pre-post intervention preliminary efficacy study (N=10) completed a baseline survey, used the app for 2 weeks, and completed an end-of-study survey. The primary outcome measures were medication adherence and medication self-efficacy. Feedback on the use of the app was also gathered.

RESULTS

A statistically significant median increase of 8 points on the self-efficacy for adherence to medications scale was observed (P=.03, Cohen d=0.69). Though not significant, the adherence to refills and medications scale demonstrated a median change of 2.5 points in the direction of increased medication adherence (P=.21, Cohen d=0.41). Feedback about the app was positive.

CONCLUSIONS

Use of the Medisafe app is a viable option to improve medication self-efficacy and medication adherence in medically underserved patients in an outpatient setting with a variety of chronic illnesses.
Prediction of the chronicity of inflammatory diseases of the urinary system in children
Authors: Lezhenko H.O. , Zakharchenko N.A.
Published: July 2023

Background. The purpose was stratification of factors that lead to the chronicity of inflammatory diseases of the urinary system in children, as well as creation of a mathematical model for predicting their course. Materials and methods. The research group consisted of 97 children (average age — 10.0 ± 1.3 years). The main group was divided into subgroups: the first one — 43 children with acute urinary tract infections (UTIs), the second one — 34 patients with chronic UTIs. The control group consisted of 20 conditionally healthy children. The content of 1,25(OH)2D3, vitamin D-binding protein, inducible nitric oxide synthase (NOS2), cystatin C, cathelicidin, hepcidin, lactoferrin, interleukins 6, 15 was investigated by immunoenzymatic analysis. The impact of factor characteristics on the process of UTI chronicity was evaluated using factor and cluster analyses. A logistic regression equation was used to predict the probability of developing chronic UTIs. The quality of the constructed model was assessed by its sensitivity and specificity, and receiver operator characteristic (ROC) analysis was also used. Results. It was found that 6 factors had the greatest significance: the factor of functional disorders of the urinary tract, the factor of comorbid conditions, the protective factor, the immune factor, chronic foci of the disease, and the NOS2 factor. According to the results of logistic regression, the model for predicting the probability of developing chronic UTI in children had the form of an equation that included 6 variables (early manifestation of the disease, vitamin D level, vesicoureteral reflux, dysmetabolic nephropathy, neurogenic bladder, UTI in the mother in childhood). The classification ability of the model was determined based on the data of the training sample and was 75.0 %. The sensitivity of the model was 78.3 %, and the specificity was 76.5 %. The area under the ROC curve that corresponded to our mathematical model was equal to 0.776. The Gini index was 55.2 %, which corresponds to the good quality of the model. Conclusions. The process of chronicity of the inflammatory process in the urinary system in children occurs under the conditions of the interaction of some pathological factors. The leading risk factors for the chronicity of the inflammatory process are the presence of functional disorders of the urinary tract, early manifestation of the disease, the level of vitamin D, intestinal dysfunction, and the presence of UTI in the mother in childhood.
The role of microRNA in the development of liver diseases. Part 2
Authors: Abaturov A.E. , Babуch V.L.
Published: July 2023

The scientific review shows the role of miRNA in the development of liver diseases, namely hepatocellular carcinoma. To write the article, we have searched for information in the Scopus, Web of Science, MedLine, PubMed, Google Scholar, ­EMBASE, Global Health, The Cochrane Library databases. In the development of hepatocellular carcinoma, the role of miRNAs involved in the regulation of the cell cycle, apoptosis, invasion, metastasis, and angiogenesis is emphasized. Scientists believe that loss of ­miR-122 expression in liver cancer correlates with inhibition of the liver phenotype and increased risk of metastasis. It is noted that the development of hepatocellular carcinoma is accompanied by an increase in the level of let-7, miR-26, miR-101 and a decrease in the concentration of miR-17-92, miR-181, miR-221 in blood serum, which can be used as diagnostic criteria. MiR-21 is considered a typical onco-microRNA and the level of circulating miR-21 in peripheral blood can serve as a potential biomarker of the early stage of hepatocellular carcinoma. In hepatocellular carcinoma, a low content of miR-34 is noted, which leads to the activation of the cyclin Е and an increase in the proliferative potential, which favors hepatocarcinogenesis. MiR-34a has an inhibitory effect on almost all oncogenic cellular processes. The researchers demonstrated that the change in the microRNA spectrum is mediated by the primary change in the generation of some circular single-stranded RNAs — circular RNAs. Thus, scientific studies of recent years confirm that miRNAs in the development of hepatocellular carcinoma are involved in the regulation of the cell cycle, apoptosis, invasion, metastasis, angiogenesis. As a potential biomarker of the early stage of hepatocellular carcinoma, the researchers identify the level of miR-21 in blood serum and consider it a typical onco-microRNA. MiR-34a has an inhibitory effect on almost all oncogenic cellular processes in hepatocellular carcinoma. Therefore, microRNAs play a very important role in the development of hepatocellular carcinoma and can be used as diagnostic and prognostic criteria, and factors of pathogenesis whose medicinal modulation will contribute to increasing the effectiveness of therapy.
IMPACT OF LEARNING ORIENTATION ON COMPANY PERFORMANCE: MEDIATING ROLE OF INNOVATIVENESS
Authors: Mirić Marija , Nikolic Jelena , Zlatanović Dejana
Published: July 2023

Ensuring a workforce is up to date on the latest trends in a rapidly changing business environment is one of the main challenges facing modern companies. To achieve long-term profitability and encourage innovation, they tend to constantly improve employees’ knowledge and skills. This paper aims to identify the impact of learning orientation on company performance and to test the mediating role of innovativeness in this relationship. The empirical research was conducted on a sample of 79 companies in different industries in the Republic of Serbia. Descriptive statistical analysis, correlation, and regression analysis were applied to the data collected. The research results indicate that learning orientation significantly and positively affects performance and innovativeness in Serbian companies. In addition, the findings show that firm innovativeness partially mediates the relationship between learning orientation and performance, i.e., learning orientation leads to better company performance through increased innovation in all business aspects. The paper contributes to identifying practical implications for managers, pointing out the importance of creating a learning environment and employees´ innovative behaviour as a basis for achieving better business outcomes. Therefore, managers should take a proactive approach to their human resources, providing them with opportunities to acquire new knowledge and skills and develop innovative ideas.
Company Visitor Management System
Authors: Niharika M.
Published: July 2023

Abstract: The IA Visitor Management System (VMS) is a web application designed for efficiently managing visitors to a facility or building. It features two types of logins: admin and user. Admin login allows the creation and management of rooms, while user login allows booking rooms and interacting with other users. The main feature of this VMS is creating rooms with specified maximum occupancy and available booking dates and times. Users can browse the list of available rooms and book one that suits their needs, view details of their bookings, and post about them. The app allows users to like and comment on posts related to booked rooms, building a sense of community. Users can check room availability and schedules to book. Admin can manage all the rooms, approve or reject bookings, and view a list of all bookings made. The IA Visitor Management System provides a user-friendly interface for efficient management of visitors and rooms, allowing users to interact with each other about their bookings.
Semiotics of Synthesis. Book review: Krotova, D.V. (2022). Synthesis of Arts in Russian Literature of the late 19th - the first third of the 20th century (A. Belyj, Z.N. Gippius, A.S. Green, M.M. Zoshchenko): textbook. Moscow: Direct-Media. 160 p.
Authors: Kovalenko Alexander G. , Denisenko Anastasia V.
Published: July 2023

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The communicative environment of a synchronous online Russian lesson in Chinese groups
Authors: Lebedeva Maria Yu. , Wu Do
Published: July 2023

The communicative approach to teaching Russian as a foreign language (RFL) implies that the main goal - the acquisition of communication skills - can only be achieved in a stimulative communicative environment. Meanwhile, the online format, which is currently becoming popular, is characterized by limited interaction between the participants of the educational process. Thus, the problem of developing methodological foundations for a productive communicative environment in the process of online teaching is becoming acute for the methodology of teaching RFL. The aim of this study is to describe the features of educational communication, determined by Chinese cultural and educational traditions, on the material of monolingual groups from China studying Russian in Russian universities, and to develop a methodological framework for creating a productive communicative environment for synchronous RFL online lessons, considering the specifics of students' communicative behavior. The study material included 10 synchronous online RFL lessons with a total duration of 15 hours and 51 minutes. Monolingual groups of Chinese students (A2-B2) participated in the lessons. A content analysis method using Atlas.ti software was applied to process the results. Coding was based on a deductive approach with elements of inductive approach; the coding system was based on the category of social presence, operationalized and adapted to the specifics of RFL learning. The prevalence of several communication behavior patterns among Chinese students, which conflict with the current methodological principles, was shown. At the same time, deviations from conventional behavior of Chinese students at the analyzed RFL classes were observed. This suggested that despite the strong influence of cultural attitudes, the parameters of the communicative environment of an online lesson may vary depending on the teacher's efforts. It is argued that the formation of communicative environment of a synchronous online RFL lesson requires that the teacher possesses the ability to manage the interactivity of communication, to form an atmosphere of cooperation and cohesion in the online group, to maintain emotionality of online communication. The study contributes to the development of digital language teaching, forming a scientific basis for creating methodological technologies of a productive educational environment in RFL online teaching.
Review of Vishnyakova O.D., Lipgart A.A. (eds.). 2023. World Languages and Cultures as an Object of Philological Investigation. Moscow: Nauka, 456 p.
Authors: Butenina Evgeniya M.
Published: July 2023

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Global Market Reaction to the Indonesian Islamic Capital Market During Covid Outbreak
Authors: Habibi Ahmad , Normasyhuri Khavid , Ma'rifah Aula Nurul
Published: July 2023

The COVID-19 pandemic has impacted the global Islamic capital market, including Indonesia. As a result, it is critical to investigate the global stock market reaction to this issue. This study seeks to comprehend the global Islamic stock market's reaction to the Indonesian Islamic stock market, as represented by the Jakarta Islamic Index (JII), during the COVID-19 outbreak. To test the hypothesis, this study employs the Error Correction Model (ECM) techniques. The findings revealed that the global Islamic stock market had a significant influence on the Indonesian Islamic stock market during that time, both in the short and long term. This is due to the Islamic stock market's interconnected nature, which attracts investors as it allows foreigners to own Islamic stocks in Indonesia, and also offers valuable long- and short-term prospects. In addition, the globalization of the world economy, social and political relations are interrelated between countries, especially in the era of COVID-19. Because the outbreak was unavoidable, it caused global economic chaos and extreme crises, including investments in the Islamic stock market. In light of crisis, the findings of this study can be used as practical guidance for investors considering investing in the Islamic stock market.==============================================================================================================  ABSTRAK - Reaksi Pasar Global Terhadap Pasar Modal Syariah Indonesia Dalam Masa Covid-19. Pandemi COVID-19 berdampak pada pasar modal syariah global, termasuk Indonesia. Oleh karena itu, kajian yang berkaitan dengan hal tersebut sangat penting dilakukan. Penelitian ini bertujuan untuk mengkaji reaksi pasar modal syariah global terhadap pasar modal syariah Indonesia yang diwakili oleh Jakarta Islamic Index (JII) dalam masa COVID-19. Untuk menguji hipotesis, penelitian ini menggunakan teknik Error Correction Model (ECM). Hasil temuan menunjukkan bahwa pasar modal syariah global memiliki pengaruh signifikan terhadap pasar modal syariah Indonesia, baik dalam jangka pendek maupun jangka panjang. Hal ini disebabkan oleh sifat interkoneksi pasar modal syariah, yang menarik investor karena memungkinkan orang asing untuk memiliki saham syariah di Indonesia, dan juga menawarkan prospek jangka panjang dan jangka pendek yang menguntungkan. Selain itu, akibat globalisasi ekonomi, hubungan sosial dan politik antar negara saling berkaitan, terutama di era COVID-19. Karena pandemi tersebut tidak terhindarkan, kondisi ekonomi global dan krisis terjadi dalam berbagai sektor, termasuk pasar modal syariah. Temuan penelitian ini berimplikasi sebagai pedoman praktis bagi investor dalam berinvestasi di pasar modal syariah di Indonesia.
FEDERAL MEANINGS AND REGIONAL PROJECTIONS OF THE STATE YOUTH POLICY OF THE RUSSIAN FEDERATION
Authors:   Пятигорский государственный университет, Пятигорск, Россия, Майя Арташесовна Аствацатурова , Лариса Хасановна Дзахова ,   Северо-Осетинский государственный университет им. К. Л. Хетагурова, Владикавказ, Россия
Published: July 2023

Тhe article contains a political analysis of the implementation of the main principles of the state youth policy of the Russian Federation at the regional level of the constituent entities of the Russian Federation of the North Caucasian Federal District, in particular, the Republic of North Osse-tia-Alania (RNO-A). The characteristic properties of youth are singled out as a special social group that requires the appropriate political and managerial attention of the state. The program-targeted efforts of the regional profile executive body of the North Ossetia-A to implement the doctrinal principles of the Russian federal youth policy are traced. As an independent case, the content and organizational initiatives of the head of the RNO-A S.I. Menyailo on the formation of a significant information, communication and value space for interaction between the authorities and youth. Documentary empirical material is involved, meaningful on the basis of content analysis and participant observation.
ON PRACTICAL WAYS TO OVERCOME MORAL ANOMIE IN MODERN CHINESE PUBLIC ORGANIZATIONS
Authors:   Шанхайский политико-юридический университет, Шанхай, КНР, Дэфон Чу
Published: July 2023

The pursuit of personal gain in the name of the public good is a typical characteristic feature of the moral anomie of public organizations (NGOs) in China. The root cause lies in the insufficient development of the culture of public welfare, weak self-restraint of public organizations and weak government supervision. The moral management of public organizations in modern China should not only emphasize the recognition of the value of members of public organizations for the purposes of public welfare of public organizations, improve the provision of an ethical system for public organizations and increase the cultivation of individual morality of members of public organizations, but also it is necessary to strengthen systemic punishments and rewards for the socially charitable behavior of social organizations and use rigidity settlement systems, deterrence and direction of social and charitable behavior of social organizations. Speaking in a substantive way, it is necessary to foster a culture of public welfare in public organizations and promote leadership orientation to the values of public welfare, combining institutional punishments and incentives to promote the management of the behavior of public organizations in the field of public welfare, strengthen government supervision and promote the management of the anomie of public welfare of public organizations, thereby contributing to the general promotion of overcoming the anomie in the field of public welfare of public organizations, as well as general advancement in other directions.
Exploring the Determinants of Preference for Visiting Beauty & Health Multi-Shop Operate by One Person
Authors:   J-Institute, Kim Dogyeong , We Heejung
Published: July 2023

Purpose: A beauty health multi-shop is a place where two or more beauty and health-related professional services are managed, and it is divided into a multi-person multi-shop where multiple managers manage users and a one-person multi-shop that is operated by a single person. This study was conducted to conduct an objec-tive and in-depth exploration of how the preference determinants of beauty health one-person multi-shop cus-tomers are organized.
Method: As a research method, the first open-ended survey was conducted, and based on this, preliminary questions were constructed through content analysis, and the second closed-ended survey was conducted. The first survey was conducted on 95 adults with experience in using beauty and health one-person multi-shops, and the second survey was conducted on 212 questionnaires with the same experience, and the final preference de-terminants were derived through exploratory factor analysis and reliability verification.
Results: The results of the study were implied by 17 sub-constructs, 6 constructs and 1 other factor. The first three internal preference determinants were identified as manager expertise, customer care environment, and affordability, and the second three external preference determinants were identified as diversity, convenience, and member retention services.
Conclusion: Currently, in Korea, the beauty health industry is based on the health industry and the beauty industry is being mixed and converged, creating new demands that are connected to health, culture, emotions, and aesthetic pursuits. The results of this study provide an objective explanation of the determinants of consum-ers' preference for visiting beauty and health one-person multi shops, so it is expected to be used as a resource for various operational measures in the future.
Estado de coisas inconvencional ambiental e o supremo tribunal federal na promoção do constitucionalismo transformador
Authors: Macedo Lima Porto Matheus
Published: July 2023

Objetivo: o presente artigo tem por objetivo analisar o papel do Supremo Tribunal Federal –STF na promoção de um constitucionalismo transformador no contexto da omissão inconstitucional e inconvencional do Estado brasileiro na implementação de políticas ambientais. Campo de estudo: partindo do pressuposto da legitimidade que o tribunal constitucional possui para empreender leitura emancipatória e transformadora da Constituição, torna-se necessário o debate sobre o estado de coisas inconstitucional e inconvencional para o âmbito das políticas ambientais adotadas pelo Brasil levando em consideração a Arguição de Descumprimento de Preceito Fundamental 760. Método: do ponto de vista metodológico, adotou-se o método hipotético-dedutivo e utilizou-se pesquisa bibliográfica e jurisprudencial. Resultado: o Estado de Coisas Inconstitucional – ECI é mecanismo estrutural legítimo na busca de remediar situações em que há falhas estruturais nas políticas ambientais e violação massiva e sistemática dos direitos fundamentais de número indeterminado de pessoas causados por omissão estatal, e em que há litígios estruturais que demandam soluções interinstitucionais; além de inconstitucional, há um estado de coisas inconvencional nas políticas ambientais brasileiras por contrariar diversas normas e tratados internacionais de proteção ao meio ambiente e aos direitos humanos. Conclusão: o STF, como guardião da Constituição, deve atuar em favor de um constitucionalismo transformador em prol dos direitos fundamentais.
Aplicações da Matemática na Engenharia: obtenção da equação de eficiência de motores elétricos utilizando o método dos mínimos quadrados.
Authors: Ries Lisandra Kittel , Padilha Juliano Bitencourt , Bortoluzzi Adilson Pacheco , Zeitune Anesio Felipe
Published: July 2023

A eletrificação de veículos vem crescendo em larga escala, uma das etapas do projeto de eletrificação é a verificação da autonomia do veículo para diferentes perfis de uso urbano e em estradas. Para isso se faz necessário determinar a equação da eficiência do motor elétrico, em função dos valores de torque e velocidade do motor. Este trabalho tem como objetivo apresentar uma equação matemática que descreve a eficiência de um motor elétrico. Utiliza-se o método dos mínimos quadrados para determinação dos coeficientes de regressão. Explica-se o passo a passo da regressão linear e polinomial utilizando o método dos mínimos quadrados em aplicações que fazem parte do quotidiano do engenheiro eletricista.