bluuebunny/crossref_metadata_2025 huggingface dataset:
Fault classification of three phase induction motors using Bi-LSTM networks
Authors: Vanga Jeevesh , Ranimekhala Durga Prabhu , Jonnala Swathi , Jamalapuram Jhansi , Gutta Balaji , Gampa Srinivasa Rao , Alluri Amarendra
Published: May 2023

The induction motors are back bone of the modern industry and play very important role in manufacturing and transportation sectors. The induction motor faults are mainly classified into internal faults such as inter turn short circuits , broken rotors and external faults such as over load, over voltage faults and asymmetry in supply voltage. The identification of type of fault is very important for safe operation and for preventing risk of machine failures. In this work, a Bidirectional Long Short Term memory networks (Bi-LSTM)-based machine learning methodology is proposed for classification of external faults of Induction Motors. The line voltages of the three phases and the three line currents are considered as the inputs to the Bi-LSTM network for identifying types of fault. Line voltage and line current data sets are considered for six different types of fault conditions. The six different conditions of the three phase induction motor are normal output (NO), overload (OL), over voltage (OV), under voltage (UV), Voltage unbalance (VUB) and single phasing (SP). The BI-LSTM network is trained using Adam optimization algorithm. The classification results are obtained with Bi-LSTM network are compared with LSTM networks to show the advantage of the proposed approach.
The Brain Medicine Clinic: two cases highlighting the advantages of integrative care
Authors: Saravi Seyyedeh Fatemeh Bahari , Mitchell Sara Berman , Levitt Sarah
Published: May 2023

Background

Current assessment and management models often do not adequately address the many aspects of managing complex brain disorders involving disordered affect, behaviour and cognition (ABC). A more collaborative model of care, where several specialties can jointly assess and manage patients with complex brain disorders, is gaining attention.

Aims

In this case report, we present two cases that highlight the benefits of the ‘brain medicine’ clinical model.

Method

The Brain Medicine Clinic employs an integrated clinical model in which psychiatrists and neurologists provide integrated interdisciplinary assessments of patients with complex brain disorders, leading to comprehensive assessment. We describe the clinical model and the trajectories of two patients with complex brain disorders seen in this clinic. In these case descriptions, we explain how the brain medicine clinical approach leads to an improved patient experience.

Results

The Brain Medicine Clinic assessments resulted in a neurobiopsychosocial formulation of symptoms and, consequently, holistic individualised treatment plans for two patients with complex brain disorders. This approach to patients’ conditions emerges from the understanding that there are multifactorial causes of brain disorders at the social, cultural, psychological and biological level.

Conclusions

Integrated interdisciplinary assessments allow for tailored treatment plans for individuals experiencing complex brain disorders, while creating efficiencies for the patient and the healthcare system.
Investigating the role of relationship satisfaction and paternal psychological distress during pregnancy on offspring health in early life
Authors: Korhonen Laura , Nolvi Saara , Peltola Ville , Lukkarinen Minna , Korja Riikka , Karlsson Linnea , Karlsson Hasse
Published: May 2023

Background

The research on the role of father in the foetal programming of health and behaviour has received increasing attention. However, the influences of paternal depressive symptoms and couple relationship satisfaction during pregnancy – potentially mediated via maternal well-being – on the offspring's risk of infections in early life is still seldom assessed.

Aims

The aim was to investigate if paternal psychological distress during pregnancy is associated with elevated risk of recurrent respiratory infections (RRIs) for offspring at 12 months of age, and whether maternal distress mediates the association between paternal distress and offspring RRIs.

Method

The study population was drawn from the nested case–control cohort of the FinnBrain Birth Cohort Study. Children with RRIs (n = 50) were identified by maternal reports at the age of 12 months, whereas mothers did not report RRIs for the comparison group (n = 716). Parental depressive symptoms were measured with the Edinburgh Postnatal Depression Scale and couple relationship satisfaction was measured with the Revised Dyadic Adjustment Scale.

Results

The association between paternal depressive symptoms during pregnancy and offspring RRIs was mediated by maternal prenatal depressive symptoms. Additionally, paternal poorer relationship satisfaction was associated with child RRIs independently of maternal distress.

Conclusions

The results suggest different pathways through which paternal distress during pregnancy may contribute to elevated risk of offspring RRIs, and more research is needed to study their underlying mechanisms. Paternal distress and couple relationship satisfaction during pregnancy should be assessed and screened as a contributor to offspring health.
Prevalence and determinants of incident and persistent depressive symptoms among middle-aged and older adults in Thailand: prospective cohort study
Authors: Pengpid Supa , Peltzer Karl , Anantanasuwong Dararatt
Published: May 2023

Background

There are no longitudinal studies investigating determinants of incident and persistent depressive symptoms in Southeast Asia.

Aims

To estimate the proportion and correlates of incident and persistent depressive symptoms in a prospective cohort study among middle-aged and older adults (≥45 years) in Thailand.

Method

We analysed longitudinal data from the Health, Aging, and Retirement in Thailand (HART) surveys in 2015 and 2017. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression Scale. Logistic regression was used to calculate predictors of incident and persistent depressive symptoms.

Results

In total, 290 of 4528 participants without depressive symptoms in 2015 had incident depressive symptoms in 2017 (9.8%) and 76 of 640 adults had persistent depressive symptoms (in both 2015 and 2017) (18.3%). In adjusted logistic regression analysis, having diabetes (adjusted odds ratio AOR = 1.48, 95% CI 1.07–2.05), musculoskeletal conditions (AOR = 1.56, 95% CI 1.01–2.41) and having three or more chronic conditions (AOR = 2.55, 95% CI 1.67–3.90) were positively associated and higher subjective economic status (AOR = 0.47, 95% CI 0.31–0.72) and social participation (AOR = 0.66, 95% CI 0.49–0.90) were inversely associated with incident depressive symptoms. Having a cardiovascular disease (AOR = 1.55, 95% CI 1.01–2.39) and having three or more chronic conditions (AOR = 2.47, 95% CI 1.07–5.67) were positively associated and social participation (AOR = 0.48, 95% CI 0.26–0.87) was inversely associated with persistent depressive symptoms.

Conclusions

One in ten middle-aged and older adults had incident depressive symptoms at 2-year follow-up. The prevalence of incident and/or persistent depression was higher in people with a lower subjective economic status, low social participation, diabetes, musculoskeletal disorders, cardiovascular conditions and a higher number of chronic diseases.
The Influence of English on Neologisms for Nonbinary Gender Identities and Sexual Orientations in Quebec French: Between Variation and Purism
Authors: Elchacar Mireille
Published: May 2023

This article creates a portrait of recent designations of nonbinary gender identities and sexual orientations in Quebec French. It addresses how purism and the condemnation of anglicisms played a part in this vocabulary. The most frequent neologisms in the French press in Quebec are LBGT* and queer. The Office québécois de la langue française (OQLF), Quebec’s official language institution, first condemned queer because of Quebec’s sensitive history with anglicisms and created allosexuel and altersexuel to replace it. However, these terms were found to be artificial and were not very successful, bringing the OQLF the change its initial normative judgment on queer, which is now accepted. More than the negative attitude toward anglicisms in Quebec, what played a major role in the circulation of those neologisms is the need for traditionally dominated groups to gain symbolic power by choosing their own labels, especially those used in a variety of languages worldwide, strengthening the sense of identity and belonging of historically marginalized groups and individuals.
Yallah Y’All: The Development and Acceptance of Queer Jewish Language in Seattle
Authors: Perleberg Ellen , Dy Grace Elizabeth C. , Hippe Lindsay
Published: May 2023

This study investigates how queer Jewish language develops among LGBTQ Jewish people themselves and the processes by which it is learned and adopted by cis-heterosexual people in shared Jewish spaces, focusing on the influence and perceptions of Seattle as a liberal and queer-accepting city. The authors analyze virtual ethnographic interviews with queer and cis-heterosexual individuals involved in Seattle Jewish life, which discuss participants’ experiences and observations surrounding queer Jewish language, emphasizing experiences in learning and adopting queer linguistic features and attitudes toward the acceptance of queer Jewish language in Seattle. It finds that communal awareness and acceptance of queer language in Jewish spaces is largely driven by the presence of queer individuals, particularly in leadership roles.
Does Anyone Suffer From Teenage Motherhood? Mental Health Effects of Teen Motherhood in Great Britain Are Small and Homogeneous
Authors: O'Flaherty Martin , Kalucza Sara , Bon Joshua
Published: May 2023

Teen mothers experience disadvantage across a wide range of outcomes. However, previous research is equivocal with respect to possible long-term mental health consequences of teen motherhood and has not adequately considered the possibility that effects on mental health may be heterogeneous. Drawing on data from the 1970 British Birth Cohort Study, this article applies a novel statistical machine-learning approach—Bayesian Additive Regression Trees—to estimate the effects of teen motherhood on mental health outcomes at ages 30, 34, and 42. We extend previous work by estimating not only sample-average effects but also individual-specific estimates. Our results show that sample-average mental health effects of teen motherhood are substantively small at all time points, apart from age 30 comparisons to women who first became mothers at age 25‒30. Moreover, we find that these effects are largely homogeneous for all women in the sample—indicating that there are no subgroups in the data who experience important detrimental mental health consequences. We conclude that there are likely no mental health benefits to policy and interventions that aim to prevent teen motherhood.
Targeting Revolutionaries
Authors: Burton Orisanmi
Published: May 2023

This essay traces the emergence of the carceral warfare project, a clandestine campaign to infuse US prisons with the logics and techniques of counterinsurgency. First exposed by Black Liberation Army member Dhoruba bin-Wahad, the project came into being between 1970 and 1978. The article begins by discussing the theory undergirding the carceral warfare project, a reactionary idea known as “the issue exploitation thesis.” Starting in 1970, seasoned cold warriors renovated their long-standing arguments against communism for application against imprisoned Black revolutionaries. Next, the FBI’s little-known Prison Activists Surveillance Program (PRISACTS) is discussed. Focusing on the words and deeds of George Jackson and Donald Bordenkircher—two central figures positioned on opposite sides of the struggle—the essay shows how the bureau used PRISACTS to treat carceral spaces as zones of counterrevolutionary warfare. Although the FBI officially discontinued PRISACTS in 1976, the final section argues that the FBI’s counterrevolutionary methodology had already been integrated into state prison systems by this date. Ultimately, this essay demonstrates that through prisons, internal security operatives engage in a plausibly deniable form of counterinsurgency warfare that seeks to isolate political prisoners from each other, from the general prison population, from their outside networks of support, and even alienates them from themselves.
Political Prisoner or Politicized Prisoner
Authors: Wilson Stevie
Published: May 2023

Calling some prisoners political prisoners and others social prisoners classifies the former as worthy of support and the latter undeserving of it. Instead of labeling prisoners this way, it is important to recognize the political nature of incarceration and that all prisoners deserve people’s solidarity.
CONTRIBUIÇÕES CULTURAIS DO GRUPO SAMBA DE ENXADA DO TUÁ: EXPRESSÃO CULTURAL DO RECÔNCAVO DA BAHIA
Authors: Jesus Almeida Rudinea , Marques da Cruz Carva Elipaula , Santos Pinheiro Josemare
Published: May 2023

A presente pesquisa tem como objeto de estudo as contribuições culturais do Grupo Samba de Enxada do Tuá: expressão cultural do recôncavo da Bahia. Para tanto, tem como objetivo central: identificar as contribuições culturais do grupo samba de enxada para a comunidade do Tuá Cruz das Almas - BA. Do ponto de vista metodológico, o presente estudo pode ser classificado como de natureza qualitativa exploratória, cuja pesquisa de campo por meio da entrevista foi realizada em duas etapas: uma com a direção (presidente) do samba de roda responsável pelo grupo, e a segunda etapa, obedecendo os critérios de inclusão da pesquisa, foi realizada com 1 integrante de cada família das 118 existentes na comunidade, que são contribuídos ao presenciar a garantia e continuação deste legado rítmico tão importante para a cultura do Estado. Os resultados permitem identificar que háuma consciência sobre o pertencimento deste grupo de samba para com o patrimônio imaterial da humanidade; é possívelidentificar os benefícios apontados por todos os participantes sobre o bem-estar físico e mental para os idosos, além dos ganhos qualitativos construídos ao longo do percurso do grupo de samba, e para dentro da comunidade do Tuá. Deste modo, o samba de enxada da comunidade do Tuá se constitui como um samba de roda que é representativo como patrimônio e herança da cultura afro-brasileira.
Inferring evolutionary trajectories from cross-sectional transcriptomic data to mirror lung adenocarcinoma progression
Authors: Huang Kexin , Zhang Yun , Gong Haoran , Qiao Zhengzheng , Wang Tiangang , Zhao Weiling , Huang Liyu , Zhou Xiaobo
Published: May 2023

Lung adenocarcinoma (LUAD) is a deadly tumor with dynamic evolutionary process. Although much endeavors have been made in identifying the temporal patterns of cancer progression, it remains challenging to infer and interpret the molecular alterations associated with cancer development and progression. To this end, we developed a computational approach to infer the progression trajectory based on cross-sectional transcriptomic data. Analysis of the LUAD data using our approach revealed a linear trajectory with three different branches for malignant progression, and the results showed consistency in three independent cohorts. We used the progression model to elucidate the potential molecular events in LUAD progression. Further analysis showed that overexpression of BUB1B, BUB1 and BUB3 promoted tumor cell proliferation and metastases by disturbing the spindle assembly checkpoint (SAC) in the mitosis. Aberrant mitotic spindle checkpoint signaling appeared to be one of the key factors promoting LUAD progression. We found the inferred cancer trajectory allows to identify LUAD susceptibility genetic variations using genome-wide association analysis. This result shows the opportunity for combining analysis of candidate genetic factors with disease progression. Furthermore, the trajectory showed clear evident mutation accumulation and clonal expansion along with the LUAD progression. Understanding how tumors evolve and identifying mutated genes will help guide cancer management. We investigated the clonal architectures and identified distinct clones and subclones in different LUAD branches. Validation of the model in multiple independent data sets and correlation analysis with clinical results demonstrate that our method is effective and unbiased.
Hsp90 mutants with distinct defects provide novel insights into cochaperone regulation of the folding cycle
Authors: Mercier Rebecca , Yama Danielle , LaPointe Paul , Johnson Jill L.
Published: May 2023

Molecular chaperones play a key role in maintaining proteostasis and cellular health. The abundant, essential, cytosolic Hsp90 (Heat shock protein, 90 kDa) facilitates the folding and activation of hundreds of newly synthesized or misfolded client proteins in an ATP-dependent folding pathway. In a simplified model, Hsp70 first helps load client onto Hsp90, ATP binding results in conformational changes in Hsp90 that result in the closed complex, and then less defined events result in nucleotide hydrolysis, client release and return to the open state. Cochaperones bind and assist Hsp90 during this process. We previously identified a series of yeast Hsp90 mutants that appear to disrupt either the ‘loading’, ‘closing’ or ‘reopening’ events, and showed that the mutants had differing effects on activity of some clients. Here we used those mutants to dissect Hsp90 and cochaperone interactions. Overexpression or deletion of HCH1 had dramatically opposing effects on the growth of cells expressing different mutants, with a phenotypic shift coinciding with formation of the closed conformation. Hch1 appears to destabilize Hsp90-nucleotide interaction, hindering formation of the closed conformation, whereas Cpr6 counters the effects of Hch1 by stabilizing the closed conformation. Hch1 and the homologous Aha1 share some functions, but the role of Hch1 in inhibiting progression through the early stages of the folding cycle is unique. Sensitivity to the Hsp90 inhibitor NVP-AUY922 also correlates with the conformational cycle, with mutants defective in the loading phase being most sensitive and those defective in the reopening phase being most resistant to the drug. Overall, our results indicate that the timing of transition into and out of the closed conformation is tightly regulated by cochaperones. Further analysis will help elucidate additional steps required for progression through the Hsp90 folding cycle and may lead to new strategies for modulating Hsp90 function.
Assessment of quality of essential medicines in public health care facilities of Nepal: Findings of nationwide study
Authors: Dhakal Neelam , Gyanwali Pradip , Humagain Baburam , BC Rajendra , Jha Nisha , Sah Phoolgen , Pradhan Amita , Dhimal Meghnath , Jha Anjani Kumar
Published: May 2023

Essential medicines are those medicines that satisfy the primary health care needs of the citizens. Poor quality of essential medicines can have serious impact on public health. Thus, this study is aimed to assess the quality of essential medicines available in public health care facilities of Nepal. A cross sectional descriptive study was carried out in 62 health facilities across 21 districts, representing all seven provinces of Nepal and selected proportionately from all three ecological regions i.e. Terai, Hill and Mountain using lottery method. Health facilities in selected districts were chosen using random number generator. Face to face interview was taken with health facility in charge using structured questionnaire. All storage conditions information was recorded through observation checklists. Temperature and humidity were measured using a digital instrument. Similarly, 20 different generic medicines were collected for quality testing. The obtained data were entered in Epidata version 3.1, cleaned in Microsoft Excel 2007 and analyzed in SPSS version 16.0. Among 62 health facilities, only 13% of health facilities were found to follow the medicine storage guidelines, with temperature and humidity levels exceeding recommended limits. Out of 244 batches of 20 different generics of essential medicines, 37 batches were found to be substandard. These substandard medicines were- Ciprofloxacin hydrochloride eye/ear drop, Iron supplement tablets, Metformin Hydrochloric tablet, Metronidazole Tablets, Paracetamol Oral suspension, Paracetamol tablet and Povidone Iodine solution. The study recommends the urgent need for the Government of Nepal to prioritize ensuring the quality of essential medicines in the country.
Malaria and typhoid fever among patients presenting with febrile illnesses in Ga West Municipality, Ghana
Authors: Rufai Tanko , Aninagyei Enoch , Akuffo Kwadwo Owusu , Ayin Christian Teye-Muno , Nortey Priscillia , Quansah Reginald , Cudjoe Francis Samuel , Tei-Maya Ernest , Osei Duah Junior Isaiah , Danso-Appiah Anthony
Published: May 2023

Background

Clinicians in areas where malaria and typhoid fever are co-endemic often treat infected patients irrationally, which may lead to the emergence of drug resistance and extra cost to patients. This study determined the proportion of febrile conditions attributable to either malaria and/or typhoid fever and the susceptibility patterns of Salmonella spp. isolates to commonly used antimicrobial agents in Ghana.

Methods

One hundred and fifty-seven (157) febrile patients attending the Ga West Municipal Hospital, Ghana, from February to May 2017 were sampled. Blood samples were collected for cultivation of pathogenic bacteria and the susceptibility of the Salmonella isolates to antimicrobial agents was performed using the Kirby-Bauer disk diffusion method with antibiotic discs on Müller Hinton agar plates. For each sample, conventional Widal test for the detection of Salmonella spp was done as well as blood film preparation for detection of Plasmodium spp. Data on the socio-demographic and clinical characteristics of the study participants were collected using an android technology software kobo-collect by interview.

Results

Of the total number of patients aged 2–37 years (median age = 6 years, IQR 3–11), 82 (52.2%) were females. The proportion of febrile patients with falciparum malaria was 57/157 (36.3%), while Salmonella typhi O and H antigens were detected in 23/157 (14.6%) of the samples. The detection rate of Salmonella spp in febrile patients was 10/157 (6.4%). Malaria and typhoid fever coinfection using Widal test and blood culture was 9 (5.7%) and 3 (1.9%), respectively. The isolates were highly susceptible to cefotaxime, ceftriaxone, ciprofloxacin, and amikacin but resistant to ampicillin, tetracycline, co-trimoxazole, gentamicin, cefuroxime, chloramphenicol, and meropenem.

Conclusion

Plasmodium falciparum and Salmonella spp coinfections were only up to 1.9%, while malaria and typhoid fever, individually, were responsible for 36.3% and 6.4%, respectively. Treatment of febrile conditions must be based on laboratory findings in order not to expose patients to unnecessary side effects of antibiotics and reduce the emergence and spread of drug resistance against antibiotics.
Ultrasonic characteristics and equivalent crack width of coal and rock bodies around boreholes during progressive failure
Authors: Ji Xiang , Zhang Tianjun , Zhang Lei , Yang Wen , Zhang Hang
Published: May 2023

The ultrasonic characteristics of the coal and rock bodies around boreholes during failure are closely related to the crack propagation law. To investigate the ultrasonic characteristics and crack propagation law of coal and rock bodies around boreholes, different grouting samples with boreholes were taken to carry out ultrasonic test during progressive failure. The ultrasonic amplitude, velocity and attenuation coefficient of the samples were analyzed. According to the ultrasonic time difference formula, the equivalent crack width of the sample during the failure process is calculated. The influence of grouting material on the crack propagation law is quantitatively analyzed. The results show that: (1) The peak stress, elastic energy at the peak, ultrasonic parameters and crack propagation of the coal and rock bodies around boreholes show obvious differences influenced by the strength of the grouting material. (2) During the loading process, the arrival time of the first wave of the sample with holes is 5μs later than that of the grouting sample, and the ultrasonic energy attenuates fastest in the time domain, and the coda wave is not developed. (3) During the progressive failure, the ultrasonic velocity and attenuation coefficient of all show three stages of stability(0~0.6σp), slow change(0.6σp~0.8σp) and rapid change(0.8σp~1.0σp). According to the "sudden decrease" of velocity and the "sudden increase" of attenuation coefficient to judge the crack propagation of sample. (4) The equivalent crack width of the sample increases exponentially with the increase of stress level. At the time of reaching the peak stress, the equivalent crack width of SH-BH increases about 0.027mm~0.032mm, SH-PU about 0.01mm~0.014mm, and SH-CEM about 0.002mm~0.006mm.
Bridging archaeology and marine conservation in the Neotropics
Authors: Fossile Thiago , Herbst Dannieli Firme , McGrath Krista , Toso Alice , Giannini Paulo César Fonseca , Milheira Rafael Guedes , Gilson Simon-Pierre , Ferreira Jessica , Bandeira Dione da Rocha , Haimovici Manuel , Ceretta Bruna , Bender Mariana G. , Colonese André Carlo
Published: May 2023

Anthropogenic impacts on tropical and subtropical coastal environments are increasing at an alarming rate, compromising ecosystem functions, structures and services. Understanding the scale of marine population decline and diversity loss requires a long-term perspective that incorporates information from a range of sources. The Southern Atlantic Ocean represents a major gap in our understanding of pre-industrial marine species composition. Here we begin to fill this gap by performing an extensive review of the published data on Middle and Late Holocene marine fish remains along the southern coast of Brazil. This region preserves archaeological sites that are unique archives of past socio-ecological systems and pre-European biological diversity. We assessed snapshots of species compositions and relative abundances spanning the last 9500 years, and modelled differences in species’ functional traits between archaeological and modern fisheries. We found evidence for both generalist and specialist fishing practices in pre-European times, with large body size and body mass caught regularly over hundreds of years. Comparison with modern catches revealed a significant decline in these functional traits, possibly associated with overfishing and escalating human impacts in recent times.
Feasibility of self-organized blood sample collection in adults for study purposes in a primary care setting
Authors: Schröder Dominik , Müller Frank , Heesen Gloria , Hummers Eva , Dopfer-Jablonka Alexandra , Vahldiek Kai , Klawonn Frank , Steffens Sandra , Mikuteit Marie , Niewolik Jacqueline , Heinemann Stephanie
Published: May 2023

Background/aims

The COVID-19 pandemic situation poses new challenges for research. Ethical issues might arise if especially vulnerable individuals for severe COVID-19 course expose themselves because of participation in studies to a higher risk of infection for study purposes. How is the feasibility and acceptance of self-organized blood sample collections to measure anti-SARS-CoV-2 Spike IgG antibodies in persons with a high risk for a severe COVID-19 disease progression?

Methods

Persons with a high risk for a severe COVID-19 disease progression (immunocompromised, oncology patients or over 80 years old) were recruited between January and September 2021 to send in blood samples (at least 500 μl) 1 month and 6 months after second COVID-19 vaccination. Participants were given the choice of drawing capillary or venous blood themselves or having blood drawn by health professionals belonging to either the study’s own research team or the personnel found in local practices or clinics. Participants were surveyed via a telephone interview in December 2021 and January 2022 about their choice of blood sampling methods and influence of blood collection choice upon study participation.

Results

Data from 360 participants was collected via telephone follow-up. First blood samples were collected by the participants themselves (35.8%), local practices or clinics (31.9%) and the research team (22.5%). Second blood samples were mostly collected in local practices or clinics (35.6%) followed by participants themselves (25.9%) and the research team (11.5%). Blood samples were not collected in 2.5% and 19.1% of persons during first and second blood draw, respectively. Only 2% of blood samples did not reach the laboratory or were not analyzable. About one-fourth (26%) of participants stated that they would not have participated in the study if it would have been required to travel to the university hospital to give their blood sample.

Conclusions

Participants were able to self-organize blood collection, making use of several different blood sample methods. Nearly all blood samples were analyzable when self-collected and sent in by post. One-fourth of the participants would not have participated in the study if required to give their blood sample in the study location.

Trial registration

German Clinical Trial Registry, DRKS00021152.
RYGB surgery has modest effects on intestinal morphology and gut hormone populations in the bypassed biliopancreatic limb but causes reciprocal changes in GLP-2 and PYY in the alimentary limb
Authors: Sridhar Ananyaa , Khan Dawood , Elliott Jessie A. , Naughton Violetta , Flatt Peter R. , Irwin Nigel , Moffett Charlotte R.
Published: May 2023

Roux-en-Y gastric-bypass (RYGB) induced alterations in intestinal morphology and gut-cell hormone expression profile in the bypassed biliopancreatic-limb (BPL) versus the alimentary-limbs (AL) are poorly characterised. This pilot study has therefore explored effects following RYGB in high-fat-diet (HFD) and normal-diet (ND) rats. Female Wistar rats (4-week-old) were fed HFD or ND for 23-weeks prior to RYGB or sham surgeries. Immunohistochemical analysis of excised tissue was conducted three-weeks post-surgery. After RYGB, intestinal morphology of the BPL in both HFD and ND groups was unchanged with exception of a small decrease in villi width in the ND-RYGB and crypt depth in the HFD-RYGB group. However, in the AL, villi width was decreased in ND-RYGB rats but increased in the HFD-RYGB group. In addition, crypt depth decreased after RYGB in the AL of HFD rats. GIP positive cells in either limb of both groups of rats were unchanged by RYGB. Similarly, there was little change in GLP-1 positive cells, apart from a small decrease of numbers in the villi of the BPL in HFD rats. RYGB increased GLP-2 cell numbers in the AL of ND-RYGB rats, including in both crypts and villi. This was associated with decreased numbers of cells expressing PYY in the AL of ND-RYGB rats. The BPL appears to maintain normal morphology and unchanged enteroendocrine cell populations despite being bypassed in RYGB-surgery. In contrast, in the AL, villi area is generally enhanced post-RYGB in ND rats with increased numbers of GLP-2 positive cells and decreased expression of PYY.
Factorial and network structure of the Reynolds Adolescent Depression Scale (RADS-2) in Peruvian adolescents
Authors: Ramos-Vera Cristian , Quispe Callo Gleni , Basauri Delgado Miguel , Vallejos Saldarriaga José , Saintila Jacksaint
Published: May 2023

Depression in young people is considered a public health problem, given that it affects their personal, social, and academic lives; therefore, early detection of depressive symptoms is of importance for a favorable prognosis. This study aimed to estimate the psychometric properties of the second edition of the Reynolds Adolescent Depression Scale (RADS-2) in Peruvian adolescents. The sample was composed of 917 Peruvian adolescents, aged 13 to 18 years (M = 15,241, SD = 1,020), who were selected from two public educational institutions in Metropolitan Lima. Confirmatory factor analysis supported the 25-item model with the four-dimensional structure and its overall and interdimensional reliability. This structure was found to be gender invariant. Finally, network analysis was performed to assess the relationships and centralities of the depressive symptoms of the validated version of the RADS-2. The results show that the RADS-2 measure is a consistent and reliable test that yields valid results in the Peruvian adolescent context.
Human presence and infrastructure impact wildlife nocturnality differently across an assemblage of mammalian species
Authors: Procko Michael , Naidoo Robin , LeMay Valerie , Burton A. Cole
Published: May 2023

Wildlife species may shift towards more nocturnal behavior in areas of higher human influence, but it is unclear how consistent this shift might be. We investigated how humans impact large mammal diel activities in a heavily recreated protected area and an adjacent university-managed forest in southwest British Columbia, Canada. We used camera trap detections of humans and wildlife, along with data on land-use infrastructure (e.g., recreation trails and restricted-access roads), in Bayesian regression models to investigate impacts of human disturbance on wildlife nocturnality. We found moderate evidence that black bears (Ursus americanus) were more nocturnal in response to human detections (mean posterior estimate = 0.35, 90% credible interval = 0.04 to 0.65), but no other clear relationships between wildlife nocturnality and human detections. However, we found evidence that coyotes (Canis latrans) (estimates = 0.81, 95% CI = 0.46 to 1.17) were more nocturnal and snowshoe hares (Lepus americanus) (estimate = -0.87, 95% CI = -1.29 to -0.46) were less nocturnal in areas of higher trail density. We also found that coyotes (estimate = -0.87, 95% CI = -1.29 to -0.46) and cougars (Puma concolor) (estimate = -1.14, 90% CI = -2.16 to -0.12) were less nocturnal in areas of greater road density. Furthermore, coyotes, black-tailed deer (Odocoileus hemionus), and snowshoe hares were moderately more nocturnal in areas near urban-wildland boundaries (estimates and 90% CIs: coyote = -0.29, -0.55 to -0.04, black-tailed deer = -0.25, -0.45 to -0.04, snowshoe hare = -0.24, -0.46 to -0.01). Our findings imply anthropogenic landscape features may influence medium to large-sized mammal diel activities more than direct human presence. While increased nocturnality may be a promising mechanism for human-wildlife coexistence, shifts in temporal activity can also have negative repercussions for wildlife, warranting further research into the causes and consequences of wildlife responses to increasingly human-dominated landscapes.
Metabolic syndrome and life style factors among diabetes patients attending in a teaching hospital, Chitwan
Authors: Sharma Kalpana , Poudyal Sunita , Subba Hem K. , Khatiwada Saurav
Published: May 2023

Background

Metabolic syndrome (MetS) is associated with an increased incidence of chronic complications and mortality of diabetes patients. Prevention and treatment of MetS is important means of lowering the risk of cardiovascular diseases and mortality.

Objective

This study aimed to find out metabolic syndrome and life style factors among diabetes patients.

Methods

A cross-sectional survey was carried out among 296 patients with type 2 diabetes mellitus attending Chitwan Medical College Teaching Hospital. Consecutive sampling technique was used to select sample. Data were collected from 15th December 2021 to 15th March, 2022 using Interview Schedule, bio-physiological measurement and record review. Obtained data were analysed in SPSS version 20 for window using descriptive and inferential statistics. Chi-square test was applied to measure the association between the variables. Logistic regression analysis was performed to identify the factors associated with metabolic syndrome.

Result

Findings revealed that the prevalence of MetS was 66.2% and 58.4% in patients according to International Diabetes Federation (IDF) and National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) criteria respectively. The most common MetS parameters were raised fasting plasma glucose (94.6%) and abnormal waist circumference (78.4% in IDF criteria) while the least prevalent parameter was reduced HDL level (43.2%). Majorities of the patients were non-vegetarian (85.5%), had poor dietary compliance (poor-46.3%, very poor-32.1%), overweight/obese (65.5%), and suffered from moderate stress (90.1%). Bivariate analysis showed that MetS as per NCEP ATP criteria was significantly associated with gender (p = 0.006), occupation (p = 0.007), presence of other co-morbid condition (<0.001) and sleep problem (p = <0.001). However, MetS as per IDF criteria was significantly associated with age (p = <0.028), duration of diabetes (p = <0.001), follow-up visit (p = <0.030), blood sugar monitoring (p = <0.009) and physical activity of diabetes patients (p = <0.001). Further logistic regression analysis revealed that sleep problem (AOR = 21.812;95%CI = 8.512,55.894) and presence of other comorbidities (AOR = 4.024;95%CI = 2.220,7.295) were the significant factors of metabolic syndrome.

Conclusion and recommendation

Metabolic syndrome is high in patients with type 2 diabetes mellitus. Therefore, treating physicians and other health workers need to monitor MetS parameters regularly to reduce the risk of cardiovascular diseases, stroke and premature death.
Investigation of artificial intelligence integrated fluorescence endoscopy image analysis with indocyanine green for interpretation of precancerous lesions in colon cancer
Authors: Kim Jinhyeon , Kim Hajung , Yoon Yong Sik , Kim Chan Wook , Hong Seung-Mo , Kim Sungjee , Choi Doowon , Chun Jihyun , Hong Seung Wook , Hwang Sung Wook , Park Sang Hyoung , Yang Dong-Hoon , Ye Byong Duk , Byeon Jeong-Sik , Yang Suk-Kyun , Kim Sun Young , Myung Seung-Jae
Published: May 2023

Indocyanine green (ICG) has been used in clinical practice for more than 40 years and its safety and preferential accumulation in tumors has been reported for various tumor types, including colon cancer. However, reports on clinical assessments of ICG-based molecular endoscopy imaging for precancerous lesions are scarce. We determined visualization ability of ICG fluorescence endoscopy in colitis-associated colon cancer using 30 lesions from an azoxymethane/dextran sulfate sodium (AOM/DSS) mouse model and 16 colon cancer patient tissue-samples. With a total of 60 images (optical, fluorescence) obtained during endoscopy observation of mouse colon cancer, we used deep learning network to predict four classes (Normal, Dysplasia, Adenoma, and Carcinoma) of colorectal cancer development. ICG could detect 100% of carcinoma, 90% of adenoma, and 57% of dysplasia, with little background signal at 30 min after injection via real-time fluorescence endoscopy. Correlation analysis with immunohistochemistry revealed a positive correlation of ICG with inducible nitric oxide synthase (iNOS; r > 0.5). Increased expression of iNOS resulted in increased levels of cellular nitric oxide in cancer cells compared to that in normal cells, which was related to the inhibition of drug efflux via the ABCB1 transporter down-regulation resulting in delayed retention of intracellular ICG. With artificial intelligence training, the accuracy of image classification into four classes using data sets, such as fluorescence, optical, and fluorescence/optical images was assessed. Fluorescence images obtained the highest accuracy (AUC of 0.8125) than optical and fluorescence/optical images (AUC of 0.75 and 0.6667, respectively). These findings highlight the clinical feasibility of ICG as a detector of precancerous lesions in real-time fluorescence endoscopy with artificial intelligence training and suggest that the mechanism of ICG retention in cancer cells is related to intracellular nitric oxide concentration.
Morphometrics of waterlogged archaeological seeds give new insights into the domestication and spread of Papaver somniferum L. in Western Europe
Authors: Jesus Ana , Bonhomme Vincent , Evin Allowen , Soteras Raül , Jacomet Stefanie , Bouby Laurent , Antolín Ferran
Published: May 2023

Domesticated opium poppy Papaver somniferum L. subsp. somniferum probably originated in the Western Mediterranean from its possible wild progenitor, Papaver somniferum L. subsp. setigerum and spread to other European regions. Seeds of opium poppy have been identified in different European regions since the Early Neolithic (from the 6th millennium cal. BC onwards) period. However, until recently, the absence of morphological identification criteria has prevented the discrimination between wild and domestic morphotypes. New morphometric approaches to distinguish modern subspecies have been proven to be applicable to waterlogged archaeological remains, opening the possibility of understanding the process of domestication of the plant in both time and space. This paper applies seed outline analyses, namely elliptic Fourier transforms, combined with size and number of cells to archaeological waterlogged Papaver seeds throughout the Neolithic period in the NW Mediterranean and the surroundings of the Alps. Furthermore, one example from the Late Bronze Age (LBA) was added to see what kind of differences appeared during the >1000 years between the end of the Neolithic and the LBA. The aim of the study is to classify the archaeological seeds as domestic or wild morphotypes and observe morphometric changes in connection to geographical and chronological patterns that can explain the spread and domestication process(es) of this important crop. A total of 295 archaeological seeds coming from 10 waterlogged sites dating between 5300–2300 cal. BC (Neolithic), and one LBA site dating to 1070 cal. BC were analysed. The results indicate the presence of seeds, similar to the wild morphotype, in the Mediterranean sites and larger seeds, similar to the domestic morphotype, in the regions surrounding the Alps. The number of cells mainly increased during the Late Neolithic (3300 to 2300 cal. BC) and, finally, in the Late Bronze Age (ca. 1050–800 cal. BC), larger, morphologically domesticated seeds are clearly predominant. A change in the shape of the seeds is only clearly visible in the LBA material. Altogether our results suggest that opium poppy seeds show no sign of domestication in the early periods of the Neolithic, despite the fact that the plant was very probably already cultivated at that time in the western Mediterranean region.
Dyspnea induced by inspiratory loading limits dual-tasking in healthy young adults
Authors: Chauvin Stephanie R. , Otoo-Appiah Jessica , Zheng Anna , Ibrahim Chris H. , Ma James E. , Rozenberg Dmitry , Reid W. Darlene
Published: May 2023

Objectives

Dyspnea is a common and multidimensional experience of healthy adults and those with respiratory disorders. Due to its neural processing, it may limit or interfere with cognition, which may be examined with a dual-task paradigm. The aim of this study was to compare single-task performance of Stroop Colour and Word Test (SCWT) or inspiratory threshold loading (ITL) to their combined dual-task performance. Secondly, whether mood was related to dyspnea or cognitive performance was also evaluated.

Materials & methods

A virtual pre-post design examined single (SCWT and ITL) and dual-task (SCWT+ITL) performance. For ITL, a Threshold Trainer™ was used to elicit a “somewhat severe” rating of dyspnea. The SCWT required participants to indicate whether a colour-word was congruent or incongruent with its semantic meaning. The Depression, Anxiety and Stress Scale-21 (DASS-21) was completed to assess mood. Breathing frequency, Borg dyspnea rating, and breathing endurance time were ascertained.

Results

Thirty young healthy adults (15F, 15M; median age = 24, IQR [23–26] years) completed the study. SCWT+ITL had lower SCWT accuracy compared to SCWT alone (98.6%, [97.1–100.0] vs 99.5%, [98.6–100.0]; p = 0.009). Endurance time was not different between ITL and SCWT+ITL (14.5 minutes, [6.9–15.0]) vs 13.7 minutes, [6.1–15.0]; p = 0.59). DASS-21 scores positively correlated with dyspnea scores during ITL (rho = 0.583, p<0.001) and SCWT+ITL (rho = 0.592, p<0.001).

Conclusions

ITL significantly reduced dual-task performance in healthy young adults. Lower mood was associated with greater perceived dyspnea during single and dual-task ITL. Considering the prevalence of dyspnea in respiratory disorders, the findings of this dual task paradigm warrant further exploration to inform dyspnea management during daily activities.
Treatment burden in individuals living with and beyond cancer: A systematic review of qualitative literature
Authors: Adam Rosalind , Nair Revathi , Duncan Lisa F. , Yeoh Esyn , Chan Joanne , Vilenskaya Vaselisa , Gallacher Katie I.
Published: May 2023

Background

Individuals with cancer are being given increasing responsibility for the self-management of their health and illness. In other chronic diseases, individuals who experience treatment burden are at risk of poorer health outcomes. Less is known about treatment burden and its impact on individuals with cancer. This systematic review investigated perceptions of treatment burden in individuals living with and beyond cancer.

Methods and findings

Medline, CINAHL and EMBASE databases were searched for qualitative studies that explored treatment burden in individuals with a diagnosis of breast, prostate, colorectal, or lung cancer at any stage of their diagnostic/treatment trajectory. Descriptive and thematic analyses were conducted. Study quality was assessed using a modified CASP checklist. The review protocol was registered on PROSPERO (CRD42021145601). Forty-eight studies were included. Health management after cancer involved cognitive, practical, and relational work for patients. Individuals were motivated to perform health management work to improve life-expectancy, manage symptoms, and regain a sense of normality. Performing health care work could be empowering and gave individuals a sense of control. Treatment burden occurred when there was a mismatch between the resources needed for health management and their availability. Individuals with chronic and severe symptoms, financial challenges, language barriers, and limited social support are particularly at risk of treatment burden. For those with advanced cancer, consumption of time and energy by health care work is a significant burden.

Conclusion

Treatment burden could be an important mediator of inequities in cancer outcomes. Many of the factors leading to treatment burden in individuals with cancer are potentially modifiable. Clinicians should consider carefully what they are asking or expecting patients to do, and the resources required, including how much patient time will be consumed.