bluuebunny/crossref_metadata_2025 huggingface dataset:
Intraspecific Diversity of Microbial Anti-Inflammatory Molecule (MAM) from Faecalibacterium prausnitzii
Authors: Auger Sandrine , Kropp Camille , Borras-Nogues Esther , Chanput Wasaporn , Andre-Leroux Gwenaelle , Gitton-Quent Oscar , Benevides Leandro , Breyner Natalia , Azevedo Vasco , Langella Philippe , Chatel Jean-Marc
Published: February 2022

The commensal bacterium Faecalibacterium prausnitzii has unique anti-inflammatory properties, at least some of which have been attributed to its production of MAM, the Microbial Anti-inflammatory Molecule. Previous phylogenetic studies of F. prausnitzii strains have revealed the existence of various phylogroups. In this work, we address the question of whether MAMs from different phylogroups display distinct anti-inflammatory properties. We first performed wide-scale identification, classification, and phylogenetic analysis of MAM-like proteins encoded in different genomes of F. prausnitzii. When combined with a gene context analysis, this approach distinguished at least 10 distinct clusters of MAMs, providing evidence for functional diversity within this protein. We then selected 11 MAMs from various clusters and evaluated their anti-inflammatory capacities in vitro. A wide range of anti-inflammatory activity was detected. MAM from the M21/2 strain had the highest inhibitory effect (96% inhibition), while MAM from reference strain A2-165 demonstrated only 56% inhibition, and MAM from strain CNCM4541 was almost inactive. These results were confirmed in vivo in murine models of acute and chronic colitis. This study provides insights into the family of MAM proteins and generates clues regarding the choice of F. prausnitzii strains as probiotics for use in targeting chronic inflammatory diseases.
Regulation of Autophagy by the Glycogen Synthase Kinase-3 (GSK-3) Signaling Pathway
Authors: Pan Hsuan-Yeh , Valapala Mallika
Published: February 2022

Autophagy is a vital cellular mechanism that benefits cellular maintenance and survival during cell stress. It can eliminate damaged or long-lived organelles and improperly folded proteins to maintain cellular homeostasis, development, and differentiation. Impaired autophagy is associated with several diseases such as cancer, neurodegenerative diseases, and age-related macular degeneration (AMD). Several signaling pathways are associated with the regulation of the autophagy pathway. The glycogen synthase kinase-3 signaling pathway was reported to regulate the autophagy pathway. In this review, we will discuss the mechanisms by which the GSK-3 signaling pathway regulates autophagy. Autophagy and lysosomal function are regulated by transcription factor EB (TFEB). GSK-3 was shown to be involved in the regulation of TFEB nuclear expression in an mTORC1-dependent manner. In addition to mTORC1, GSK-3β also regulates TFEB via the protein kinase C (PKC) and the eukaryotic translation initiation factor 4A-3 (eIF4A3) signaling pathways. In addition to TFEB, we will also discuss the mechanisms by which the GSK-3 signaling pathway regulates autophagy by modulating other signaling molecules and autophagy inducers including, mTORC1, AKT and ULK1. In summary, this review provides a comprehensive understanding of the role of the GSK-3 signaling pathway in the regulation of autophagy.
Biotechnological Applications and Health-Promoting Properties of Flavonols: An Updated View
Authors: Gervasi Teresa , Calderaro Antonella , Barreca Davide , Tellone Ester , Trombetta Domenico , Ficarra Silvana , Smeriglio Antonella , Mandalari Giuseppina , Gattuso Giuseppe
Published: February 2022

Flavonols are a subclass of natural flavonoids characterized by a remarkable number of biotechnological applications and health-promoting properties. They attract researchers’ attention due to many epidemiological studies supporting their usage. They are phytochemicals commonly present in our diet, being ubiquitous in the plant kingdom and, in particular, relatively very abundant in fruits and vegetables. All these aspects make flavonols candidates of choice for the valorization of products, based on the presence of a remarkable number of different chemical structures, each one characterized by specific chemical features capable of influencing biological targets inside the living organisms in very different manners. In this review, we analyzed the biochemical and physiological characteristics of flavonols focalizing our attention on the most promising compounds to shed some light on their increasing utilization in biotechnological applications in processing industries, as well as their suitable employment to improve the overall wellness of the humankind.
Asymptomatic Bacteriuria or Urinary Tract Infection? New and Old Biomarkers
Authors: Martino Francesca K , Novara Giacomo
Published: February 2022

Urinary tract infections (UTIs) are among the most common infective disease in the adult population. UTI diagnosis is based essentially on the presence of lower urinary tract symptoms (e.g., dysuria, urgency, and frequency) and the evidence of bacteriuria (by dipstick testing and/or urine culture). UTI diagnosis is not always easy because symptoms can be vague, or patient basal conditions can interfere negatively with the diagnostic process, whereas urine culture is still ongoing. In those cases, the differential diagnosis among UTIs and asymptomatic bacteriuria (ABU) may be challenging, while the clinician has to decide whether to start an antibiotic treatment shortly. The purpose of the present review is to analyze the biomarkers that could help in UTI diagnosis. Some biomarkers, such as procalcitonin, interleukin-6, neutrophil gelatinase-associated lipocalin, chemokines, lactoferrin, and bone morphogenetic protein-2, seem promising in UTI diagnosis, while other biomarkers failed to show any utility. Whereas a single biomarker was not enough, a combination of biomarkers could have more chances to help in the diagnosis.
External Validation of a Novel Comprehensive Trifecta System in Predicting Oncologic and Functional Outcomes of Partial Nephrectomy: Results of a Multicentric Series
Authors: Anceschi Umberto , Flammia Rocco Simone , Mattevi Daniele , Tufano Antonio , Brassetti Aldo , Ferriero Maria Consiglia , Tuderti Gabriele , Misuraca Leonardo , Bove Alfredo Maria , Mastroianni Riccardo , Marsiliani Davide , Puglisi Marco , Cai Tommaso , Leonardo Costantino , Gallucci Michele , Malossini Gianni , Luciani Lorenzo Giuseppe , Simone Giuseppe
Published: February 2022

Background: To validate a novel trifecta for evaluating outcomes of partial nephrectomy (PN) on a multicentric dataset. Methods: Between 2007 and 2020, three renal cancer databases were queried for patients with solitary renal masses who underwent PN (n = 649). Trifecta was estimated for overall cohort and contributing centers. Overall survival (OS), cancer-specific survival (CSS) and end-stage renal disease (ESRD) probabilities were assessed by Kaplan–Meier. Cox regression was used to identify predictors of OS, CSS, ESRD. For all analyses, a p < 0.05 was considered significant. Results: At a median follow-up of 22.7 months (IQR 12.5–76.5) overall trifecta was 76.7% [Centre A; (n = 230; 68.6%), B (n = 68; 77.3%), C (n = 200; 88.4%); p = 0.001). On Kaplan–Meier, patients achieving trifecta exhibited higher OS (p = 0.024), higher CSS (p = 0.015) and lower ESRD rates (p = 0.024). On multivariable analysis, age (HR 1.04; 95% CI 1.01–1.08) and trifecta (HR 0.34; 95% CI 0.15–0.76) were independent predictors of OS while pT stage (HR 1.95; 95% CI 0.45–8.43) and trifecta (HR 0.33; 95% CI 0.16–0.67) were predictors of CSS (each p < 0.01). Preoperative CKD stage ≥ 3a (HR 13.1; 95% CI 4.07–42.6) and trifecta (HR 0.41; 95% CI 0.19–0.87) were independent predictors of ESRD (each p < 0.05). Conclusions: On external validation, trifecta was an independent predictor of all PN endpoints, regardless of hilar control and ischemia duration.
Which Strategies and Corresponding Competences Are Needed to Improve Supply Chain Resilience: A COVID-19 Based Review
Authors: Kiers Jethro , Seinhorst Jaap , Zwanenburg Mirthe , Stek Klaas
Published: February 2022

Background: During the COVID-19 pandemic, it became evident that supply chains were not as resilient as they should be. To cope with future disruptions or epidemic outbreaks, supply chain resilience should be improved based on lessons learnt from the impacts of COVID-19 to improve supply chain resilience and facilitate the corresponding competences and skills to implement strategic changes. Method: Applying the dynamic managerial capabilities theory lens, an integrative review is conducted focused on (1) the multiple impacts of COVID-19 on the supply chain resilience, (2) multiple strategies to enhance supply chain resilience, and (3) competences needed to implement the strategic changes successfully. Result: During COVID-19, supply chains could not handle supply and demand shocks, which led to a disrupted state of supply chains. To reduce the impacts of the subsequent disruptions, companies should implement specific strategic changes and increase complementary skills and competences levels. A proposed framework indicates which skills and competences need to be developed to implement a strategic change. Conclusion: Companies must shift their focus from (cost) efficiency to creating more resilient supply chains. Additionally, purchasing professionals should develop their skills and competences accordingly to cope with future disruptions.
Energetic Materials Based on N-substituted 4(5)-nitro-1,2,3-triazoles
Authors: Sukhanov Gennady T. , Filippova Yulia V. , Gatilov Yuri V. , Sukhanova Anna G. , Krupnova Irina A. , Bosov Konstantin K. , Pivovarova Ekaterina V. , Krasnov Vyacheslav I.
Published: February 2022

The regularities and synthetic potentialities of the alkylation of 4(5)-nitro-1,2,3-triazole in basic media were explored, and new energetic ionic and nitrotriazole-based coordination compounds were synthesized in this study. The reaction had a general nature and ended with the formation of N1-, N2-, and N3-alkylation products, regardless of the conditions and reagent nature (alkyl- or aryl halides, alkyl nitrates, dialkyl sulfates). This reaction offers broad opportunities for expanding the variability of substituents on the nitrotriazole ring in the series of primary and secondary aliphatic, alicyclic, and aromatic substituents, which is undoubtedly crucial for solving the problems related to both high-energy materials development and medicinal chemistry when searching for new efficient bioactive compounds. An efficient methodology for the separation of regioisomeric N-alkyl(aryl)nitrotriazoles has been devised and relies on the difference in their basicity and reactivity during quaternization and complexation reactions. Based on the inaccessible N3-substitution products that exhibit a combination of properties of practical importance, a series of energy-rich ionic systems and coordination compounds were synthesized that are gaining ever-increasing interest for the chemistry of energy-efficient materials, coordination chemistry, and chemistry of ionic liquids.
Innovative Concepts and Recent Breakthrough for Engineered Graft and Constructs for Bone Regeneration: A Literature Systematic Review
Authors: Inchingolo Francesco , Hazballa Denisa , Inchingolo Alessio Danilo , Malcangi Giuseppina , Marinelli Grazia , Mancini Antonio , Maggiore Maria Elena , Bordea Ioana Roxana , Scarano Antonio , Farronato Marco , Tartaglia Gianluca Martino , Lorusso Felice , Inchingolo Angelo Michele , Dipalma Gianna
Published: February 2022

Background: For decades, regenerative medicine and dentistry have been improved with new therapies and innovative clinical protocols. The aim of the present investigation was to evaluate through a critical review the recent innovations in the field of bone regeneration with a focus on the healing potentials and clinical protocols of bone substitutes combined with engineered constructs, growth factors and photobiomodulation applications. Methods: A Boolean systematic search was conducted by PubMed/Medline, PubMed/Central, Web of Science and Google scholar databases according to the PRISMA guidelines. Results: After the initial screening, a total of 304 papers were considered eligible for the qualitative synthesis. The articles included were categorized according to the main topics: alloplastic bone substitutes, autologous teeth derived substitutes, xenografts, platelet-derived concentrates, laser therapy, microbiota and bone metabolism and mesenchymal cells construct. Conclusions: The effectiveness of the present investigation showed that the use of biocompatible and bio-resorbable bone substitutes are related to the high-predictability of the bone regeneration protocols, while the oral microbiota and systemic health of the patient produce a clinical advantage for the long-term success of the regeneration procedures and implant-supported restorations. The use of growth factors is able to reduce the co-morbidity of the regenerative procedure ameliorating the post-operative healing phase. The LLLT is an adjuvant protocol to improve the soft and hard tissues response for bone regeneration treatment protocols.
Influence of Strain Route Changes on the Microstructure and Mechanical Properties of CuZn36 Alloy during Cross Channel Extrusion CCE
Authors: Łyszkowski Radosław
Published: February 2022

This study evaluates the impact of changing the deformation routes of the extrusion process in a cross-shaped die (CCE) on the structure and properties of a CuZn36 alloy (% at.). Samples with dimensions of Ø8 × 36 mm were subjected to extrusion at room temperature according to two variants: straight extrusion in the A route (2-, 4-, 8- and 12-pass) and extrusion with interoperative rotation by 90° in the BC route (2- and 4-pass). The improvement of strength properties was obtained as a result of grain fragmentation in the CCE process. Changes in the microstructure were observed using a light microscope, and mechanical properties were measured in the microhardness test and a static tensile test. The obtained results showed that the mechanical properties of the alloy depend on the number of passes and the material deformation route. This observation was related to the fragmentation of its structure and strengthening, which resulted in changes in its properties. The highest strength was characterized by the material pressed four times with the rotation of 90° (BC route), whose properties were comparable and even slightly better than the material squeezed twelve times without rotation (A route).
Biphasic Properties of PVAH (Polyvinyl Alcohol Hydrogel) Reflecting Biomechanical Behavior of the Nucleus Pulposus of the Human Intervertebral Disc
Authors: Heo Minhyeok , Park Seonghun
Published: February 2022

PVAH is a mixture of solid and fluid, but its mechanical behavior has usually been described using solid material models. The purpose of this study was to obtain material properties that can reflect the mechanical behavior of polyvinyl alcohol hydrogel (PVAH) using finite element analysis, a biphasic continuum model, and to optimize the composition ratio of PVAH to replace the nucleus pulposus (NP) of the human intervertebral disc. Six types of PVAH specimens (3, 5, 7, 10, 15, 20 wt%) were prepared, then unconfined compression experiments were performed to acquire their material properties using the Holmes–Mow biphasic model. With an increasing weight percentage of PVA in PVAH, the Young’s modulus increased while the permeability parameter decreased. The Young’s modulus and permeability parameter were similar to those of the NP at 15 wt% and 20 wt%. The range of motion, facet joint force, and NP pressures measured from dynamic motional analysis of the lumbar segments with the NP model also exhibited similar values to those with 15~20 wt% PVAH models. Considering the structural stability and pain of the lumbar segments, it appears that 20 wt% PVAH is most suitable for replacing the NP.
Dynamic Characteristics and Damage Constitutive Model of Mudstone under Impact Loading
Authors: Zhou Ruihe , Cheng Hua , Cai Haibing , Wang Xiaojian , Guo Longhui , Huang Xianwen
Published: February 2022

The mechanical response characteristics of mudstone from the ingate roadway of the west ventilation shaft in Yuandian No. 2 coal mine, Huaibei City, Anhui Province, China to dynamic loads were quantified in single- and cyclic-impact compression tests, using the split-Hopkinson pressure bar test device. The dynamic stress–strain relationships and the failure characteristics of mudstone samples under different impact loads were analyzed systematically. Considering the “rate effect” of the mudstone dynamic strength, the dynamic strength criterion of mudstone was proposed, and the dynamic damage constitutive model of mudstone was established, based on the statistical damage theory. In response to single-impact loads, with increasing impact pressure, the mudstone peak stress and strain gradually increased, and the peak stress and average strain rate increased nonlinearly. In response to cyclic-impact loads, with an increasing number of impacts, the mudstone peak stress first increased and then decreased, and the peak strain increased gradually. With increasing impact pressure, the number of impacts to the samples’ failure decreased gradually. By parameter identification and comparative analysis of the test results, the proposed dynamic damage constitutive model of mudstone was validated. The model can be used for stability analysis of roadway-surrounding rock under dynamic loads.
Microstructure Evolution and Improved Permeability of Ceramic Waste-Based Bricks
Authors: Zhou Wenfei , Du Huiling , Kang Le , Du Xian , Shi Yupu , Qiang Xiaojing , Li Haodong , Zhao Jing
Published: February 2022

The resource and large-scale utilization of waste ceramic materials, magnesium slag, and coal gangue are one of the important ways for the sustainable development in metallurgy, coal, and other related enterprises. In this paper, waste ceramic materials were used as aggregates; coal gangue and magnesium slag were used as mixed binder; and the all solid-waste-based permeable bricks with excellent performance were prepared by forming pressure at 5 MPa. The mechanical properties and water permeability of the all-solid-waste-based permeable bricks were evaluated. The results proved that the porous channel of permeable brick is mainly composed of waste ceramic materials with a particle size of 2–3 mm. Pore structures below 200 μm were mainly composed of fine aggregate and mixed binder. Using 60% coarse aggregate, 20% fine aggregate, 10% coal gangue, and 10% magnesium slag as raw materials, the all-solid-waste-based permeable bricks were obtained by pressing at 6 MPa and sintering at 1200 °C, which exhibited the best performance, and its water permeability, compressive strength, and apparent porosity were 1.56 × 10−2 cm/s, 35.45 MPa, and 13.15%, respectively. Excellent water permeability, compressive strength, and apparent porosity of the all solid-waste-based permeable bricks were ascribed to the high content of connecting open pores, and closely adhesive force were ascribed to the porous microstructure constructed by the grading of waste ceramic materials and the tight conjoined points of the liquid phases in coal gangue and magnesium slag at a high sintering temperature.
Enzymatic Catalysis in Favor of Blocky Structure and Higher Crystallinity of Poly(Butylene Succinate)-Co-(Dilinoleic Succinate) (PBS-DLS) Copolymers of Variable Segmental Composition
Authors: Sokołowska Martyna , Nowak-Grzebyta Jagoda , Stachowska Ewa , El Fray Miroslawa
Published: February 2022

To systematically investigate the synthesis of poly(butylene succinate)-co-(dilinoleic succinate) (PBS-DLS) copolymers and to enrich the library of polyesters synthesized via a sustainable route, we conducted a two-step polycondensation using fully biobased monomers such as diethyl succinate (DS), 1,4-butanediol (1,4-BD) and dilinoleic diol (DLD) in diphenyl ether, using Candida Antarctica lipase B (CAL-B) as biocatalyst. A series of PBS-DLS copolyesters with a 90-10, 70-30 and 50-50 wt% of hard (PBS) to soft (DLS) segments ratio were compared to their counterparts, which were synthesized using heterogenous titanium dioxide/silicon dioxide (TiO2/SiO2) catalyst. Chemical structure and molecular characteristics of resulting copolymers were assessed using nuclear magnetic spectroscopy (1H- and 13C-NMR) and gel permeation chromatography (GPC), whereas thermal and thermomechanical properties as well as crystallization behavior were investigated by differential scanning microscopy (DSC), dynamic mechanical thermal analysis (DMTA), digital holographic microscopy (DHM) and X-ray diffraction (XRD). The obtained results showed that, depending on the type of catalyst, we can control parameters related to blockiness and crystallinity of copolymers. Materials synthesized using CAL-B catalysts possess more blocky segmental distribution and higher crystallinity in contrast to materials synthesized using heterogenous catalysts, as revealed by DSC, XRD and DHM measurements.
Removing Auxetic Properties in f.c.c. Hard Sphere Crystals by Orthogonal Nanochannels with Hard Spheres of Another Diameter
Authors: Narojczyk Jakub W. , Bilski Mikołaj , Grima Joseph N. , Kędziora Przemysław , Morozow Dmitrij , Rucki Mirosław , Wojciechowski Krzysztof W.
Published: February 2022

Negative Poisson’s ratio materials (called auxetics) reshape our centuries-long understanding of the elastic properties of materials. Their vast set of potential applications drives us to search for auxetic properties in real systems and to create new materials with those properties. One of the ways to achieve the latter is to modify the elastic properties of existing materials. Studying the impact of inclusions in a crystalline lattice on macroscopic elastic properties is one of such possibilities. This article presents computer studies of elastic properties of f.c.c. hard sphere crystals with structural modifications. The studies were performed with numerical methods, using Monte Carlo simulations. Inclusions take the form of periodic arrays of nanochannels filled by hard spheres of another diameter. The resulting system is made up of two types of particles that differ in size. Two different layouts of mutually orthogonal nanochannels are considered. It is shown that with careful choice of inclusions, not only can one impact elastic properties by eliminating auxetic properties while maintaining the effective cubic symmetry, but also one can control the anisotropy of the cubic system.
Optimization of Polymer Processing: A Review (Part II-Molding Technologies)
Authors: Gaspar-Cunha António , Covas José A. , Sikora Janusz
Published: February 2022

The application of optimization techniques to improve the performance of polymer processing technologies is of great practical consequence, since it may result in significant savings of materials and energy resources, assist recycling schemes and generate products with better properties. The present review aims at identifying and discussing the most important characteristics of polymer processing optimization problems in terms of the nature of the objective function, optimization algorithm, and process modelling approach that is used to evaluate the solutions and the parameters to optimize. Taking into account the research efforts developed so far, it is shown that several optimization methodologies can be applied to polymer processing with good results, without demanding important computational requirements. Furthermore, within the field of artificial intelligence, several approaches can reach significant success. The first part of this review demonstrated the advantages of the optimization approach in polymer processing, discussed some concepts on multi-objective optimization and reported the application of optimization methodologies to single and twin screw extruders, extrusion dies and calibrators. This second part focuses on injection molding, blow molding and thermoforming technologies.
Crystal Plasticity Simulation of Yield Loci Evolution of SUS304 Foil
Authors: Men Mingliang , Meng Bao
Published: February 2022

The deformation process of metal foils is usually under a complex stress status, and the size effect has an obvious influence on the microforming process. To study the effect of grain orientation and grain size distribution on the yield loci evolution of SUS304 stainless steel foils, three representative volume element (RVE) models were built based on the open source tools NEPER and MTEX. In addition, the yield loci with different grain sizes are obtained by simulation with Duisseldorf Advanced Material Simulation Kit (DAMASK) under different proportional loading conditions. The initial yield loci show a remarkable difference in shape and size, mainly caused by the distinct texture characteristics. By comparing the crystal plasticity simulation with the experimental results, the model with normal grain size distribution and initial texture based on Electron Back-scattered Diffraction (EBSD) data can more accurately describe the influence of the size effect on the shape and size of yield loci, which is the result of the interaction of grain size distribution and texture. However, the enhancement of grain deformation coordination will weaken the impact of the size effect on yield loci shape if the grain size distribution is more uniform.
Fracture Strength and Failure Modes of Endodontically Treated Premolars Restored with Compact and Hollow Composite Posts Subjected to Cyclic Fatigue
Authors: Gallicchio Vito , Lodato Vincenzo , De Santis Roberto , Rengo Sandro
Published: February 2022

Physical and mechanical properties of continuous carbon or glass fiber reinforced endodontic posts are relevant to increase the retention and resistance of the tooth-restoration system. Hollow posts have been recently designed for delivering the luting cement through the post hole, thus enhancing the post-dentin interface by reducing the risk of air bubbles formation. Methods: Three type of endodontic posts, a carbon fiber hollow post, a glass fiber hollow post and a compact glass fiber post were investigated. Mechanical properties of these posts were assessed through bending tests. Teeth were subjected to fatigue cycling and the strength of restored teeth was detected through static tests. Failure modes were investigated through optical and scanning electron microscopy. Results show that composite posts increase the mechanical stability by more than 100% compared to premolars restored with particulate composite. Carbon fiber posts retain the highest strength (1467 N ± 304 N) among the investigated post and core restoration, but an unfavorable type of fracture has been observed, preventing the tooth re-treatment. Instead, more compliant posts (i.e., glass fiber reinforced composite, providing a strength of 1336 N ± 221 N), show a favorable mode of fracture that allows the re-treatment of teeth in the case that failure occurs. Glass fiber hollow posts show a good trade-off between strength and a favorable type of fracture.
Long Persistent Luminescent HDPE Composites with Strontium Aluminate and Their Phosphorescence, Thermal, Mechanical, and Rheological Characteristics
Authors: Poulose Anesh Manjaly , Shaikh Hamid , Anis Arfat , Alhamidi Abdullah , Kumar Nadavala Siva , Elnour Ahmed Yagoub , Al-Zahrani Saeed M.
Published: February 2022

In this work, HDPE/strontium aluminate-based auto glowing composites (SrAl2O4: Eu, Dy (AG1) and Sr4Al14O25: Eu, Dy (AG2)) were prepared, and their phosphorescence studies were conducted. In HDPE/AG1 composites, the green emission was observed at ~500 nm after the UV excitation at 320 nm. The HDPE/AG2 has a blue emission at ~490 nm and, in both cases, the intensity of emission is proportional to the AG1 and AG2 content. The DSC data show that the total crystallinity of both the composites was decreased but with a more decreasing effect with the bulky AG2 filler. The melting and crystallization temperatures were intact, which shows the absence of any chemical modification during high shear and temperature processing. This observation is further supported by the ATR-FTIR studies where no new peaks appeared or disappeared from the HDPE peaks. The tensile strength and modulus of HDPE, HDPE/AG1, and HDPE/AG2 composites were improved with the AG1 and AG2 fillers. The rheological studies show the improvement in the complex viscosity and accordingly the storage modulus of the studied phosphorescent HDPE composites. The SEM images indicate better filler dispersion and filler–matrix adhesion, which improves the mechanical characteristics of the studied HDPE composites. The ageing studies in the glowing composites show that there is a decrease in the intensity of phosphorescence emission on exposure to drastic atmospheric conditions for a longer period and the composites become more brittle.
Nanostructures as Radionuclide Carriers in Auger Electron Therapy
Authors: Gharibkandi Nasrin Abbasi , Gierałtowska Joanna , Wawrowicz Kamil , Bilewicz Aleksander
Published: February 2022

The concept of nanoparticle-mediated radionuclide delivery in the cancer treatment has been widely discussed in the past decade. In particular, the use of inorganic and organic nanostructures in the development of radiopharmaceuticals enables the delivery of medically important radioisotopes for radionuclide therapy. In this review, we present the development of nanostructures for cancer therapy with Auger electron radionuclides. Following that, different types of nanoconstructs that can be used as carriers for Auger electron emitters, design principles, nanoparticle materials, and target vectors that overcame the main difficulties are described. In addition, systems in which high-Z element nanoparticles are used as radionuclide carriers, causing the emission of photoelectrons from the nanoparticle surface, are presented. Finally, future research opportunities in the field are discussed as well as issues that must be addressed before nanoparticle-based Auger electron radionuclide therapy can be transferred to clinical use.
Flexural Strength of Concrete Beam Reinforced with CFRP Bars: A Review
Authors: Bakar Mohd Basri Che , Muhammad Rashid Raizal Saifulnaz , Amran Mugahed , Saleh Jaafar Mohd , Vatin Nikolai Ivanovicn , Fediuk Roman
Published: February 2022

Conventional reinforced concrete (RC) structures are commonly associated with the corrosion of steel reinforcement. The application of carbon fiber reinforced polymer (CFRP) bars as flexural reinforcement has become a new promising option. This paper presents a state-of-the art flexural strength on concrete beams reinforced with CFRP bars. Concrete compressive and CFRP bar tensile strain, reinforcement ratio, types of surface treatment on CFRP bar and concrete compressive strength were identified as aspects of behavior. Significant findings in the literature had manifested all aspects of behavior that were affecting the flexural strength, deflections and crack characteristics of CFRP RC beams. In addition, the experimental result on 98 specimens of CFRP RC beams from the literature show that ACI 440.1R-15 and CSA S806-12 standards underestimate the ultimate flexural moment capacity of CFRP RC beams. On the other hand, Kara and Ashour predictions are more accurate with the experimental values. Moreover, hotspot research topics were also highlighted for further considerations in future studies.
Increasing Impact Strength of a Short Glass Fiber Compression Molded BMC by Shortening Fibers without Change in Equipment
Authors: Faudree Michael C. , Nishi Yoshitake , Salvia Michelle
Published: February 2022

Bird strike, volcanic rock, hailstones, micrometeoroids, or space debris can cause damage to aircraft and space vehicles, therefore their composite materials must have high impact resistance to maximize safety. In a 55% wt. CaCO3 compression molded short glass fiber polyester GFRP-BMC (bulk molded compound), shortening the nominal 6.4 mm fiber length formulation, by 30 min extended mixing, to 0.44 mm was found to increase Charpy impact values, auc, without a change in the compression molding equipment. Specimens were cut from square panels in a spiral configuration in conformity with ASTM D 6110-02 for orthotropic panels, the flow direction approximately radially outward from the charge. At a median-fracture probability of Pf = 0.50, extended mixing improved auc by 29%, from 7.43 to 9.59 kJm−2, and for each solidification texture angle, namely, 0 to 90 (random), 71, 45 and 18 deg, the auc increased by 25% (6.26 to 7.86 kJm−2), 18% (9.36 to 11.07 kJm−2), 35% (7.68 to 10.37 kJm−2), and 20% (6.96 to 8.36 kJm−2), respectively. This strengthening can be explained by an increased number of thermal compressive stress sites between the glass fiber and matrix due to a difference in the coefficient of thermal expansion (CTE) during cool-down, and shrinkage, with an increased number of spaces between fibers, |Sf| from 217 to approximately 2950 per mm3, enhancing impact energy.
Metallurgical Coke Production with Biomass Additives: Study of Biocoke Properties for Blast Furnace and Submerged Arc Furnace Purposes
Authors: Bazaluk Oleg , Kieush Lina , Koveria Andrii , Schenk Johannes , Pfeiffer Andreas , Zheng Heng , Lozynskyi Vasyl
Published: February 2022

Biocoke has the potential to reduce the fossil-based materials in metallurgical processes, along with mitigating anthropogenic CO2- and greenhouse gas (GHG) emissions. Reducing those emissions is possible by using bio-based carbon, which is CO2-neutral, as a partial replacement of fossil carbon. In this paper, the effect of adding 5, 10, 15, 30, and 45 wt.% biomass pellets on the reactivity, the physicomechanical, and electrical properties of biocoke was established to assess the possibility of using it as a fuel and reducing agent for a blast furnace (BF) or as a carbon source in a submerged arc furnace (SAF). Biocoke was obtained under laboratory conditions at final coking temperatures of 950 or 1100 °C. Research results indicate that for BF purposes, 5 wt.% biomass additives are the maximum as the reactivity increases and the strength after reaction with CO2 decreases. On the other hand, biocoke’s physicomechanical and electrical properties, obtained at a carbonization temperature of 950 °C, can be considered a promising option for the SAF.
Effect of Assembly Errors on Ground Tooth Surface Deviations for Large-Scale CNC Gear Profile Grinding Machines
Authors: Ding Wenzheng , He Wenquan , Zhang Hu , Li Yao
Published: February 2022

Assembling plays a significant role in the performance of large-scale CNC gear profile grinding machines. An approach in the deviation evaluation of ground tooth surfaces taking into account assembly errors is proposed in this paper. Based on the error transmission chain of the profile grinding system and the conjugate motion relationship between the grinding wheel and the workpiece, the ground tooth surface model including assembly errors was established using the surface envelope method. Then, the effect of assembly errors on deviations of the profile grinding tooth surface was quantitatively analyzed. The optimized distribution of assembly errors and machining verifications were performed on large-scale CNC gear profile grinding machines. The results show that the proposed method is effective at ensuring ground tooth surface deviations for large-scale CNC gear profile grinding machines.
A Self-Parametrization Framework for Meta-Heuristics
Authors: Santos André S. , Madureira Ana M. , Varela Leonilde R.
Published: February 2022

Even while the scientific community has shown great interest in the analysis of meta-heuristics, the analysis of their parameterization has received little attention. It is the parameterization that will adapt a meta-heuristic to a problem, but it is still performed, mostly, empirically. There are multiple parameterization techniques; however, they are time-consuming, requiring considerable computational effort and they do not take advantage of the meta-heuristics that they parameterize. In order to approach the parameterization of meta-heuristics, in this paper, a self-parameterization framework is proposed. It will automatize the parameterization as an optimization problem, precluding the user from spending too much time on parameterization. The model will automate the parameterization through two meta-heuristics: A meta-heuristic of the solution space and one of the parameter space. To analyze the performance of the framework, a self-parameterization prototype was implemented. The prototype was compared and analyzed in a SP (scheduling problem) and in the TSP (traveling salesman problem). In the SP, the prototype found better solutions than those of the manually parameterized meta-heuristics, although the differences were not statistically significant. In the TSP, the self-parameterization prototype was more effective than the manually parameterized meta-heuristics, this time with statistically significant differences.
Novel Photovoltaic Empirical Mathematical Model Based on Function Representation of Captured Figures from Commercial Panels Datasheet
Authors: Hassan Ola , Zakzouk Nahla , Abdelsalam Ahmed
Published: February 2022

Photovoltaic (PV) technology is gaining much interest as a clean, sustainable, noise-free source of energy. However, the non-linear behavior of PV modules and their dependency on varying environmental conditions require thorough study and analysis. Many PV modeling techniques have been introduced in the literature, yet they exhibit several complexity levels for parameter extraction and constants estimation for PV power forecast. Comparatively, a simple, accurate, fast, and user friendly PV modeling technique is proposed in this paper featuring the least computational time and effort. Based on function representation of PV curves’ available in PV datasheets, an empirical mathematical equation is derived. The proposed formula is considered a generic tool capable of modeling any PV device under various weather conditions without either parameter estimation nor power prediction. The proposed model is validated using experimental data of commercial PV panels’ manufacturers under various environmental conditions for different power levels. The obtained results verified the effectiveness of the proposed PV model.
Fucoidan Isolated from Sargassum confusum Suppresses Inflammatory Responses and Oxidative Stress in TNF-α/IFN-γ- Stimulated HaCaT Keratinocytes by Activating Nrf2/HO-1 Signaling Pathway
Authors: Jayasinghe Arachchige Maheshika Kumari , Kirindage Kirinde Gedara Isuru Sandanuwan , Fernando Ilekuttige Priyan Shanura , Han Eui Jeong , Oh Gun-Woo , Jung Won-Kyo , Ahn Ginnae
Published: February 2022

Recent studies have revealed that marine brown seaweeds contain numerous bioactive compounds which exhibit various bioactivities. The present study investigated the effect of low molecular weight fucoidan (SCF) isolated from Sargassum confusum, a brown alga, on inflammatory responses and oxidative stress in HaCaT keratinocytes stimulated by tumor necrosis factor (TNF)-α/interferon (IFN)-γ. SCF significantly increased the cell viability while decreasing the intracellular reactive oxygen species (ROS) production in TNF-α/IFN-γ-stimulated HaCaT keratinocytes. In addition, SCF effectively reduced inflammatory cytokines (interleukin (IL)-1β, IL-6, IL-8, IL-13, TNF-α, and IFN-γ) and chemokines (Eotaxin, macrophage-derived chemokine (MDC), regulated on activation, normal T cell expressed and secreted (RANTES), and thymus and activation-regulated chemokine (TARC)) expression, by down-regulating the expression of epithelial and epidermal innate cytokines (IL-25, IL-33, and thymic stromal lymphopoietin (TSLP)). Furthermore, SCF suppressed the activation of TNF-α/IFN-γ-stimulated mitogen-activated protein kinase (MAPK) and nuclear factor-κB (NF-κB) signaling pathways, while activating the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling pathway. The cytoprotective effect of SCF against TNF-α/IFN-γ stimulation was considerably reduced upon inhibition of HO-1 activity by ZnPP. Overall, these results suggest that SCF effectively suppressed inflammatory responses and oxidative stress in TNF-α/IFN-γ-stimulated HaCaT keratinocytes via activating the Nrf2/HO-1 signaling pathway.
Xishaeleganins A–D, Sesquiterpenoid Hydroquinones from Xisha Marine Sponge Dactylospongia elegans
Authors: Chen Bao , Zhao Qingmin , Gu Yu-Cheng , Lan Lefu , Wang Chang-Yun , Guo Yue-Wei
Published: February 2022

Four new sesquiterpene hydroquinones, xishaeleganins A–D (6–9), along with eleven known related ones (12 and 14–23) were isolated from the Xisha marine sponge Dactylospongia elegans (family Thorectida). Their structures were determined by extensive spectroscopic analysis, ECD calculations, and by comparison with the spectral data reported in the literature. Compounds 7, 15, 20, and 21 showed significant antibacterial activity against Staphylococcus aureus, with minimum inhibitory concentration values of 1.5, 2.9, 5.6, and 5.6 µg/mL, which are comparable with those obtained for the positive control vancomycin (MIC: 1.0 µg/mL).
Immune Thrombocytopenic Purpura as a Hemorrhagic Versus Thrombotic Disease: An Updated Insight into Pathophysiological Mechanisms
Authors: Tărniceriu Claudia Cristina , Hurjui Loredana Liliana , Florea Irina Daniela , Hurjui Ion , Gradinaru Irina , Tanase Daniela Maria , Delianu Carmen , Haisan Anca , Lozneanu Ludmila
Published: February 2022

Immune thrombocytopenic purpura (ITP) is a blood disorder characterized by a low platelet count of (less than 100 × 109/L). ITP is an organ-specific autoimmune disease in which the platelets and their precursors become targets of a dysfunctional immune system. This interaction leads to a decrease in platelet number and, subsequently, to a bleeding disorder that can become clinically significant with hemorrhages in skin, on the mucous membrane, or even intracranial hemorrhagic events. If ITP was initially considered a hemorrhagic disease, more recent studies suggest that ITP has an increased risk of thrombosis. In this review, we provide current insights into the primary ITP physiopathology and their consequences, with special consideration on hemorrhagic and thrombotic events. The autoimmune response in ITP involves both the innate and adaptive immune systems, comprising both humoral and cell-mediated immune responses. Thrombosis in ITP is related to the pathophysiology of the disease (young hyperactive platelets, platelets microparticles, rebalanced hemostasis, complement activation, endothelial activation, antiphospholipid antibodies, and inhibition of natural anticoagulants), ITP treatment, and other comorbidities that altogether contribute to the occurrence of thrombosis. Physicians need to be vigilant in the early diagnosis of thrombotic events and then institute proper treatment (antiaggregant, anticoagulant) along with ITP-targeted therapy. In this review, we provide current insights into the primary ITP physiopathology and their consequences, with special consideration on hemorrhagic and thrombotic events. The accumulated evidence has identified multiple pathophysiological mechanisms with specific genetic predispositions, particularly associated with environmental conditions.
Impact of Hospitalization in an Endocrinology Department on Vaccination Coverage in People Living with Diabetes: A Real-Life Study
Authors: Lohan Laura , Cool Charlène , Viault Loriane , Cestac Philippe , Renard Eric , Galtier Florence , Villiet Maxime , Avignon Antoine , Sultan Ariane , Breuker Cyril
Published: February 2022

Background and Objectives: Vaccination coverage is suboptimal in people living with diabetes. The objectives of this study were to determine the impact of hospitalization on vaccination coverage and the variables associated with vaccination during hospital stay. Materials and Methods: This observational study was conducted from May 2019 to December 2019 in the Endocrinology-Nutrition-Diabetes Department of the University Hospital of Montpellier, France. This department encompasses three medical units, two of which have a full-time clinical pharmacist involved in the multidisciplinary management of patients. All adult diabetic patients who completed a questionnaire about vaccines were prospectively included by a clinical pharmacist and followed until department discharge. Coverage at the time of admission for the tetanus, diphtheria, pertussis (Tdap), pneumococcal, influenza, and herpes zoster vaccines was assessed from patient interviews and/or contact with the general practitioner and/or with the community pharmacist. Multivariable logistic regression analysis was performed to identify the factors associated with a vaccination update during the hospital stay. Results: A total of 222 patients were included (mean age: 59.4 years, 68.5% type 2 diabetes). Vaccination coverage increased by 26.7% (47.3% to 59.9%), 188.0% (10.8% to 31.1%) and 8.9% (45.9% to 50.0%), respectively, for the Tdap, pneumococcal and influenza vaccines during hospital stay. Female sex, admission to a diabetes care unit with a full-time pharmacist, favorable feelings about vaccination, unknown immunization coverage for pneumococcal vaccines, and evaluation and recording of vaccine coverage at admission in the patient medical records were associated with at least one vaccination during hospital stay. Conclusions: Our real-life study highlights that hospitalization and multidisciplinary management (i.e., physician-pharmacist) may be key points in the diabetes care pathway to improve vaccination coverage, especially for patients with advanced diabetes and comorbidities.
Compact Carbon-Based Membrane Reactors for the Intensified Anaerobic Decolorization of Dye Effluents
Authors: Amin Mohammad Shaiful Alam , Stüber Frank , Giralt Jaume , Fortuny Agustin , Fabregat Azael , Font Josep
Published: February 2022

Carbon-based membranes integrated with anaerobic biodegradation are presented as a unique wastewater treatment approach to deal with dye effluents. This study explores the scope of ceramic-supported carbon membrane bioreactors (B-CSCM) and ceramic-supported graphene oxide membrane bioreactors (B-CSGOM) to decolorize azo dye mixtures (ADM) and other dyes. The mixture was prepared using an equimolar composition of monoazo Acid Orange 7, diazo Reactive Black 5, and triazo Direct Blue 71 dye aqueous solution. Afterwards, as in the ADM experiment, both compact units were investigated for their ability in the biodecolorization of Methylene Blue (MB) and Rhodamine B (RhB) dye solutions, which do not belong to the azo family. The obtained outcomes revealed that the conductive surface of the graphene oxide (GO) membrane resulted in a more efficient and higher color removal of all dye solutions than B-CSCM under a wide feed concentration and permeate flux ranges. The maximum color removal at low feed concentration (50 mg·L−1) and permeate flux (0.05 L·m−2·h−1) was 96% for ADM, 98% for MB and 94% for RhB, whereas it was 89%, 94% and 66%, respectively, for B-CSCM. This suggests that the robust, cost-effective, efficient nanostructures of B-CSGOM can successfully remove diverse azo dye solutions from wastewater better than the B-CSCM does.