bluuebunny/crossref_metadata_2025 huggingface dataset:
Prevalence and Predictors of Loneliness Among Youth During the Time of COVID-19: A Multinational Study
Authors: Al Omari Omar , Al Sabei Sulaiman , Al Rawajfah Omar , Abu Sharour Loai , Al-Hashmi Iman , Al Qadire Mohammad , Khalaf Atika
Published: May 2021

BACKGROUND:

Given the restrictions associated with COVID-19, feelings of loneliness among youth may increase.

AIMS:

The aims of the current study were to assess the prevalence of loneliness among young people at the time of COVID-19 and to identify whether selected variables related to the pandemic predicted the level of loneliness.

METHOD:

A cross-sectional study using WhatsApp and Facebook social media platforms was conducted to survey 1,057 young people aged 15 to 24 years from six Middle Eastern countries. Participants completed survey items including demographic and COVID-19-related questions; the Depression, Anxiety and Stress Scale (DASS); the Satisfaction With Life Scale (SWLS); and the UCLA Loneliness Scale.

RESULTS:

The prevalence of experienced loneliness was 1 (0.1%), 625 (59.1%), 429 (40.6%), and 2 (0.2%), reflecting low, moderate, moderately high, and high experiences for loneliness, respectively. History of depression or anxiety, being dissatisfied with life, and having depression at the time of COVID-19 were significant predictors of loneliness among youth. The model was significant ( F = 44.95, p < .05) and accounted for 29.8% of the variance in UCLA Loneliness Scale scores.

CONCLUSIONS:

We found that the high prevalence rate of loneliness during the COVID-19 pandemic was correlated with depression and impaired life satisfaction among Middle Eastern youth. Thus, special attention and interventional action plans need to be developed taking into consideration the youths’ special situation during COVID-19.
A self-powered laminated fabric sensor for human motion detection and heart-rate monitoring based on PPy/Al Schottky contact
Authors: Yang Yuan , Zhou Guangsheng , Ye Dezhan , Bai Zikui , Deng Zhongmin , Xu Jie
Published: May 2021

Continuous real-time human motion and heart-rate monitoring systems can provide vital clinical information for disease diagnosis, preventive healthcare and rehabilitation care. However, it is still a challenge to design wearable pressure/strain sensors with great flexibility and sustainable power for motion detection and physiological signal monitoring. Here, a self-powered laminated fabric sensor based on Schottky contact was successfully fabricated. This laminated fabric sensor was constructed by sandwiching the polypyrrole (PPy)-coated fabric with the Ni-coated fabric and Al plastic film. The electrical outputs under strain were attributed to the single Schottky contact between PPy and Al. This fabric sensor exhibited excellent stability under continuous quick cycling operation and at high relative humidity, which could be adapted to different human body parts for continuous motion detection and heart-rate monitoring. This work is of great significance to demonstrate a promising strategy toward self-powered wearable pressure sensors used for human motion detecting and hear-rate monitoring.
COVID-19 and Male Sexual Functioning: A report of 3 Recovered Cases and Literature Review
Authors: Salama Nader , Blgozah Saeed
Published: May 2021

COVID-19 is a new global pandemic. It can affect multiple body systems and functions. However, the relationship between COVID-19 and male sexual activity did not yet get much consideration. Herein, we report the impact of COVID-19 on sexual function in 3 men who recovered from the disease. Compared with their condition before catching the infection, the men showed, in different degrees, a decline in all aspects of sexual function as assessed by the international index of erectile function. They started to develop premature ejaculation or exacerbate an already existing condition according to the premature ejaculation diagnostic tool scoring. Beck’s depression inventory revealed deterioration of the men’s moods up to severe depression. The sex-related hormones (testosterone-total and free, luteinizing hormone, follicle-stimulating hormone, prolactin, and estradiol) of these men were within normal levels. To the best of our knowledge, this is the first case report documenting deleterious changes in mood and several aspects of sexual functioning in males after recovery from the COVID-19 using validated measurement tools. Follow-up and psychological support of the recovered men may help mend their moods and consequently upgrade their sexual functioning.
Wear analysis of eco-friendly non-asbestos friction-lining material applied in an automotive drum brake: Experimental and finite-element analysis
Authors: Shinde Dinesh , Bulsara Mukesh , Patil Jeet
Published: May 2021

Brake friction lining material is the critical element of a braking system, since it provides friction resistance to the rotating drum for controlling automobiles. The present study involves wear analysis of newly developed eco-friendly non-asbestos friction lining material for automotive drum brake applications using experimental study, finite-element analysis, and microstructural investigations. Theoretical interpretation of braking force at different automobile speeds was derived using fundamentals. Specimen drum brake liner with eco-friendly material compositions was produced using an industrial hot compression molding process at one of the manufacturer. The surface wear of the liner was measured using an effective and accurate method. Furthermore, a finite-element analysis model was developed considering actual operating conditions and various components of the drum brake system. The model was elaborated for various result outcomes, including Von-Mises stresses and total deformation of components of the drum brake, and further used to estimate the surface wear of the friction lining material in terms of transverse directional deformation. Finally, microstructural analysis of the friction lining material was carried out using scanning electron microscopy and energy dispersive spectroscopy. From the results, it is seen that the developed friction lining material is wear resistant. The finite-element analysis model can be effectively utilized to study the tribological characteristics of friction lining materials.
Design and thermal characteristic analysis of motorized spindle cooling system
Authors: Zhang Yuan , Wang Lifeng , Zhang Yaodong , Zhang Yongde
Published: May 2021

The thermal deformation of high-speed motorized spindle will affect its reliability, so fully considering its thermal characteristics is the premise of optimal design. In order to study the thermal characteristics of high-speed motorized spindles, a coupled model of thermal-flow-structure was established. Through experiment and simulation, the thermal characteristics of spiral cooling motorized spindle are studied, and the U-shaped cooled motorized spindle is designed and optimized. The simulation results show that when the diameter of the cooling channel is 7 mm, the temperature of the spiral cooling system is lower than that of the U-shaped cooling system, but the radial thermal deformation is greater than that of the U-shaped cooling system. As the increase of the channel diameter of U-shaped cooling system, the temperature and radial thermal deformation decrease. When the diameter is 10 mm, the temperature and radial thermal deformation are lower than the spiral cooling system. And as the flow rate increases, the temperature and radial thermal deformation gradually decrease, which provides a basis for a reasonable choice of water flow rate. The maximum error between experiment and simulation is 2°C, and the error is small, which verifies the accuracy and lays the foundation for future research.
A new reference wind year approach to estimate long term wind characteristics
Authors: Pusat Saban , Karagöz Yasin
Published: May 2021

The typical meteorological year (TMY) method has common applications in building energy performance and solar energy studies. However, there is not any well accepted method for the wind energy applications such as the TMY. In the present study, a new reference year approach is proposed for wind energy applications. By using the proposed method, the reference wind year (RWY) datasets may be generated as in the TMY methodology for any measurement station which has the possibility to be used as a reference station in the measure-correlate-predict (MCP) analyses. The MCP calculations are so significant to estimate the long term wind conditions for a candidate wind farm site. In this study, a case study is performed for Turkey after giving the details of the proposed method. The results for the RWY approach has a good agreement with the long term data as in the TMY method. Therefore, the RWY concept has the possibility to make the MCP studies easier and faster.
Hotel Room Rate Discounting During Recessionary Times: Effects by Hotel Class
Authors: O’Neill John W. , Yeon Jihwan
Published: May 2021

Previous research regarding the costs and benefits of hotel room rate discounting during recessionary times has produced mixed results and recommendations. However, it has become clear that virtually all hotels offer discounted room rates during economic recessions, regardless of the conclusions of research studies, and that includes the recession that began in 2020. Media reports have indicated that certain rogue hotels are quick to offer discounted room rates during the early months of recessions, and therefore, operators of other hotels in their competitive set feel compelled to follow the lead, perhaps regretfully. This study found that while virtually all hotels offered discounted room rates during the recession of 2008 and 2009, there was variability in discounting during the early months of the recession. As a result, we sought to explore recessionary variability of room rate discounting, and to provide an empirical, nuanced perspective regarding the effectiveness of such discounting. Notably, we found the effectiveness of recessionary discounting varied depending on the class of hotel, with higher class establishments experiencing different outcomes from discounting than hotels categorized as relatively lower class properties.
Safe Zones for Spinopelvic Screws in Patients With Lumbosacral Transitional Vertebra
Authors: Becker Luis , Schömig Friederike , Haffer Henryk , Ziegeler Katharina , Diekhoff Torsten , Pumberger Matthias
Published: May 2021

Study Design:

Retrospective matched-pair analysis.

Objectives:

Lumbosacral transitional vertebrae (LSTV) have a reported prevalence of 4-36% in the population. The safe zones for screw placement for spinopelvic fusion in adult spinal deformity surgery for patients with LSTV have not been described in the literature. Our study aimed to assess the safety of S1-pedicle screw (S1PS), S2-alar screw (S2AS), S2-alar-iliac screw (S2AIS), and iliac screw (IS) placement in patients with LSTV.

Methods:

Out of the 819 examined patients, 49 patients with LSTV were included in our retrospective analysis with a matched pair control group. We used the 3-dimensional planning tool mediCAD for screw placement of S1PS, S2AS, S2AIS, IS with different angles, length and diameters.

Results:

We evaluated a total of 10 192 screw trajectories. No serious complications occurred due to the trajectories used for S1PS. LSTV increased the risk of vessel injury for S2AS trajectories ( P = .001) but not for S2AIS ( P = .526). Besides the presence of an LSTV, the screw trajectory had a major influence on the frequency of serious complications.

Conclusions:

Sacral anchoring of long spinal constructions using S1PS, S2AS, S2AIS and IS is also possible in the presence of LSTV. For S2AS the trajectory with 30° lateral and caudal angulation of 10° showed the least vascular injuries and the least sacro-iliac-joint violations in patients with LSTV. S2AIS trajectories with 40° lateral and 0° sagittal angulation reduced the risk of serious complications in our patients collective with LSTV.
Scleroderma renal crisis following Covid-19 infection
Authors: Rimar Doron , Rosner Itzhak , Slobodin Gleb
Published: May 2021

Systemic sclerosis (SSc) is an autoimmune disease in which environmental exposure to substances and agents may trigger disease onset or exacerbation. The most fatal complication of SSc is scleroderma renal crisis (SRC), the incidence of which is 2-3%. SRC usually occurs in the first 5 years from disease onset in diffuse-SSc patients with anti-topoisomerase 1 (ATA) or RNA polymerase 3 antibodies [1]. Other risk factors for SRC are pericardial effusion, tendon friction rub and steroid use. We report herein a case of scleroderma renal crisis (SRC), following covid-19 infection, in a limited-SSc patient who was in long remission prior to the infection without any risk factors for SRC. the temporal relationship and lack of other risk factors combine to suggest covid-19 infection as a possible trigger for SRC. We discuss the shared pathophysiology of covid-19 infection and SRC, including, vasculopathy, endothelial activation, hypercoagulability, cytokines release as interleukin 6, that may explain the possible role of covid-19 infection, as a trigger for SRC in SSc patients.
Liquid biopsy in extranodal NK/T-cell lymphoma: a prospective analysis of cell-free DNA genotyping and monitoring
Authors: Qi Fei , Cao Zheng , Chen Bo , Chai Yue , Lin Jing , Ye Junyi , Wei Yuce , Liu Hao , Han-Zhang Han , Mao Xinru , Feng Xiaoli , Dong Mei
Published: May 2021

Satisfactory tumor material is often hard to obtain for molecular analysis in extranodal natural killer (NK)/T-cell lymphoma (NKTCL) at present. However, the accuracy and utility of circulating cell-free DNA (cfDNA) genotyping have not been adequately assessed in NKTCL. We therefore performed targeted next-generation sequencing on tumor tissues and a series of longitudinal plasma samples prospectively collected from a cohort of high-risk NKTCL patients. Concordance of genotyping results of paired baseline tumor and cfDNA and the predictive value of dynamic cfDNA monitoring were evaluated. At baseline, 59 somatic variants in 31 genes were identified in tumor and/or plasma cfDNA among 19 out of 24 high-risk NKTCL patients (79.2%). Plasma cfDNA had a sensitivity of 72.4% for detection of somatic variants identified in tumor biopsies before treatment. Plasma cfDNA also allowed the identification of mutations that were undetectable in tumor biopsies. These results were also verified in a validation cohort of an additional 23 high-risk NKTCL patients. Furthermore, longitudinal analysis showed that patients with rapid clearance of NKTCL-related mutations from plasma had higher complete remission rates (80.0% vs 0%; P = .004) and more favorable survival (1-year progression-free survival [PFS] rate, 79.0% vs 20.0%; P = .002) compared with those with persisting or emerging mutations in plasma. In addition, low cfDNA concentration before treatment was associated with favorable survival outcome for patients with NKTCL (1-year PFS, 90.0% vs 36.4%; P = .012). In conclusion, cfDNA mirrors tumor biopsy for detection of genetic alterations in NKTCL and noninvasive dynamic plasma cfDNA monitoring might be a promising approach for tracking response and survival outcome for patients with NKTCL.
Fibroblasts positive for meflin have anti-fibrotic properties in pulmonary fibrosis
Authors: Nakahara Yoshio , Hashimoto Naozumi , Sakamoto Koji , Enomoto Atsushi , Adams Taylor S. , Yokoi Toyoharu , Omote Norihito , Poli Sergio , Ando Akira , Wakahara Keiko , Suzuki Atsushi , Inoue Masahide , Hara Akitoshi , Mizutani Yasuyuki , Imaizumi Kazuyoshi , Kawabe Tsutomu , Rosas Ivan O. , Takahashi Masahide , Kaminski Naftali , Hasegawa Yoshinori
Published: May 2021

The prognosis of elderly individuals with idiopathic pulmonary fibrosis (IPF) remains poor. Fibroblastic foci, in which aggregates of proliferating fibroblasts and myofibroblasts are involved, are the pathological hallmark lesions in IPF to represent focal areas of active fibrogenesis. Fibroblast heterogeneity in fibrotic lesions hampers the discovery of the pathogenesis of pulmonary fibrosis. Therefore, to determine the pathogenesis of IPF, identification of functional fibroblasts is warranted. The aim of this study was to determine the role of fibroblasts positive for meflin, identified as a potential marker for mesenchymal stromal cells, during the development of pulmonary fibrosis.

We characterised meflin-positive cells in a single-cell atlas established by single-cell RNA sequencing (scRNA-seq)-based profiling of 243 472 cells from 32 IPF lungs and 29 normal lung samples. We determined the role of fibroblasts positive for meflin using bleomycin (BLM)-induced pulmonary fibrosis.

scRNA-seq combined within situRNA hybridisation identified proliferating fibroblasts positive for meflin in fibroblastic foci, not dense fibrosis, of fibrotic lungs in IPF patients. A BLM-induced lung fibrosis model for meflin-deficient mice showed that fibroblasts positive for meflin had anti-fibrotic properties to prevent pulmonary fibrosis. Although transforming growth factor-β-induced fibrogenesis and cell senescence with the senescence-associated secretory phenotype were exacerbated in fibroblastsviathe repression or lack of meflin, these were inhibited in meflin-deficient fibroblasts with meflin reconstitution.

These findings provide evidence to show the biological importance of meflin expression on fibroblasts and myofibroblasts in the active fibrotic region of pulmonary fibrosis.
AICAR decreases acute lung injury by phosphorylating AMPK and upregulating heme oxygenase-1
Authors: Ahmad Israr , Molyvdas Adam , Jian Ming-Yuan , Zhou Ting , Traylor Amie M. , Cui Huachun , Liu Gang , Song Weifeng , Agarwal Anupam , Jilling Tamas , Aggarwal Saurabh , Matalon Sadis
Published: May 2021

Aim

We investigated the mechanisms by which N1-(β-d-ribofuranosyl)-5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), an activator of AMP-activated protein kinase (AMPK), decreases lung injury and mortality when administered to mice post exposure to bromine gas (Br2).

Methods

We exposed male C57BL/6 mice and heme oxygenase-1 (HO-1)-deficient (HO-1−/−) and corresponding wild-type (WT) littermate mice to Br2(600 ppm for 45 or 30 min, respectively) in environmental chambers and returned them to room air. AICAR was administered 6 h post exposure (10 mg·kg−1, intraperitoneal). We assessed survival, indices of lung injury, high mobility group box 1 (HMGB1) in the plasma, HO-1 levels in lung tissues and phosphorylation of AMPK and its upstream liver kinase B1 (LKB1). Rat alveolar type II epithelial (L2) cells and human club-like epithelial (H441) cells were also exposed to Br2(100 ppm for 10 min). After 24 h we measured apoptosis and necrosis, AMPK and LKB1 phosphorylation, and HO-1 expression.

Results

There was a marked downregulation of phosphorylated AMPK and LKB1 in lung tissues and in L2 and H441 cells post exposure. AICAR increased survival in C57BL/6 but not in HO-1−/−mice. In WT mice, AICAR decreased lung injury and restored phosphorylated AMPK and phosphorylated LKB1 to control levels and increased HO-1 levels in both lung tissues and cells exposed to Br2. Treatment of L2 and H441 cells with small interfering RNAs against nuclear factor erythroid 2-related factor 2 or HO-1 abrogated the protective effects of AICAR.

Conclusions

Our data indicate that the primary mechanism for the protective action of AICAR in toxic gas injury is the upregulation of lung HO-1 levels.
SMILE: systems metabolomics using interpretable learning and evolution
Authors: Sha Chengyuan , Cuperlovic-Culf Miroslava , Hu Ting
Published: May 2021

Background

Direct link between metabolism and cell and organism phenotype in health and disease makes metabolomics, a high throughput study of small molecular metabolites, an essential methodology for understanding and diagnosing disease development and progression. Machine learning methods have seen increasing adoptions in metabolomics thanks to their powerful prediction abilities. However, the “black-box” nature of many machine learning models remains a major challenge for wide acceptance and utility as it makes the interpretation of decision process difficult. This challenge is particularly predominant in biomedical research where understanding of the underlying decision making mechanism is essential for insuring safety and gaining new knowledge.

Results

In this article, we proposed a novel computational framework, Systems Metabolomics using Interpretable Learning and Evolution (SMILE), for supervised metabolomics data analysis. Our methodology uses an evolutionary algorithm to learn interpretable predictive models and to identify the most influential metabolites and their interactions in association with disease. Moreover, we have developed a web application with a graphical user interface that can be used for easy analysis, interpretation and visualization of the results. Performance of the method and utilization of the web interface is shown using metabolomics data for Alzheimer’s disease.

Conclusions

SMILE was able to identify several influential metabolites on AD and to provide interpretable predictive models that can be further used for a better understanding of the metabolic background of AD. SMILE addresses the emerging issue of interpretability and explainability in machine learning, and contributes to more transparent and powerful applications of machine learning in bioinformatics.
Plastome structure and phylogenetic relationships of Styracaceae (Ericales)
Authors: Cai Xiu-Lian , Landis Jacob B. , Wang Hong-Xin , Wang Jian-Hua , Zhu Zhi-Xin , Wang Hua-Feng
Published: May 2021

Background

The Styracaceae are a woody, dicotyledonous family containing 12 genera and an estimated 160 species. Recent studies have shown thatStyraxandSinojackiaare monophyletic,AlniphyllumandBruinsmiacluster into a clade with an approximately 20-kb inversion in the Large Single-Copy (LSC) region.HalesiaandPterostyraxare not supported as monophyletic, whileMelliodendronandChangiostyraxalways form sister clades.PerkinsiodendronandChangiostyraxare newly established genera of Styracaceae. However, the phylogenetic relationship of Styracaceae at the generic level needs further research.

Results

We collected 28 complete plastomes of Styracaceae, including 12 sequences newly reported here and 16 publicly available sequences, comprising 11 of the 12 genera of Styracaceae. All species possessed the typical quadripartite structure of angiosperm plastomes, with sequence differences being minor, except for a large 20-kb (14 genes) inversion found inAlniphyllumandBruinsmia. Seven coding sequences (rps4,rpl23,accD,rpoC1,psaA,rpoAandndhH) were identified to possess positively selected sites. Phylogenetic reconstructions based on seven data sets (i.e., LSC, SSC, IR, Coding, Non-coding, combination of LSC + SSC and concatenation of LSC + SSC + one IR) produced similar topologies. In our analyses, all genera were strongly supported as monophyletic.Styraxwas sister to the remaining genera.AlniphyllumandBruinsmiaform a clade.Halesia dipteradoes not cluster withPerkinsiodendron, whilePerkinsiodendronandRehderodendronform a clade.Changiostyraxis sister to a clade ofPterostyraxandSinojackia.

Conclusion

Overall, our results demonstrate the power of plastid phylogenomics in improving estimates of phylogenetic relationships among genera. This study also provides insight into plastome evolution across Styracaceae.
Three-dimensional visualization improves the endoscopic diagnosis of superficial gastric neoplasia
Authors: Higuchi Kazutoshi , Kaise Mitsuru , Noda Hiroto , Kirita Kumiko , Koizumi Eriko , Umeda Takamitsu , Akimoto Teppei , Omori Jun , Akimoto Naohiko , Goto Osamu , Tatsuguchi Atsushi , Iwakiri Katsuhiko
Published: May 2021

Background

Three-dimensional (3D) technology has been used in many fields, including flexible endoscopy. We evaluated the usefulness of 3D visualization for endoscopically diagnosing superficial gastric neoplasia.

Methods

Twelve participants (4 novices, 4 trainees and 4 experts) evaluated two-dimensional (2D) and 3D endoscopic still images of 28 gastric neoplasias, obtained before ESD with white-light imaging (WLI) and narrow-band imaging (NBI). Assessments of the delineation accuracy of tumor extent and tumor morphology under 2D and 3D visualization were based on the histopathological diagnosis of ESD specimens. Participants answered visual analog scale (VAS) questionnaires (0–10, worst to best) concerning the (a) ease of recognition of lesion morphology, (b) lesion extent and (c) comprehensive endoscopic cognition under 2D and 3D visualization. The endpoints were the accuracy of tumor extent and morphology type and the degree of confidence in assessing (a)–(c).

Results

The delineation accuracy of lesion extent [mean (95% confidence interval)] with WLI under 3D visualization [60.2% (56.1–64.3%)] was significantly higher than that under 2D visualization [52.3% (48.2–56.4%)] (P < 0.001). The accuracy with NBI under 3D visualization [70.3% (66.8–73.7%)] was also significantly higher than that under 2D visualization [64.2% (60.7–67.4%)] (P < 0.001). The accuracy of the morphology type with NBI under 3D visualization was significantly higher than that under 2D visualization (P = 0.004). The VAS for all aspects of endoscopic recognition under 3D visualization was significantly better than that under 2D visualization (P < 0.01).

Conclusions

Three-dimensional visualization can enhance the diagnostic quality for superficial gastric tumors.
Pure retroperitoneal laparoscopic radical nephrectomy and thrombectomy with delayed occlusion of the proximal inferior vena cava (DOPI) technique for renal tumor with level II-III venous tumor thrombus
Authors: Liu Zhuo , Hong Peng , Zhu Guodong , Zhang Li , Zhao Xun , Tang Shiying , Yang Feilong , Tian Xiaojun , Wang Guoliang , Zhang Shudong , Zhang Hongxian , Huang Yi , Liu Chunxia , Liu Cheng , Ma Lulin
Published: May 2021

Purpose

To explore the safety and effectiveness of delayed occlusion of the proximal inferior vena cava (DOPI) technique in retroperitoneal laparoscopic radical nephrectomy (LRN) and thrombectomy for renal tumor with level II-III venous tumor thrombus (VTT).

Materials and methods

From August 2016 to October 2018, a total of 145 patients with renal tumor and VTT were admitted to our centre. Seventy-five patients underwent laparoscopic surgery, and 70 patients underwent open surgery. Among these patients, 17 patients underwent retroperitoneal LRN and thrombectomy with the DOPI technique. Clinical data were collected retrospectively, and a descriptive statistical analysis was conducted.

Results

All the patients successfully underwent retroperitoneal laparoscopic surgery. The mean operation time was 345.9 ± 182.9 min, the mean estimated blood loss was 466.7 ± 245.5 ml. Postoperative complications occurred in three patients, including two patients of Clavien grading system level IVa and one patient of level II. There were no complications related to carbon dioxide pneumoperitoneum, such as gas embolism, acidosis, and subcutaneous emphysema. During 21 months of median follow-up time, no local recurrence was found, and distant metastasis occurred in four patients. Cancer-specific death occurred in two patients.

Conclusions

The DOPI technique is safe and feasible in the treatment of renal tumor and level II-III VTT. With the DOPI technique, the procedures of dissociating and exposing proximal inferior vena cava are simplified.
Mental health education in undergraduate medical curricula across Nepalese universities
Authors: Marahatta Kedar , Pant Sagun Ballav , Basnet Madhur , Sharma Pawan , Risal Ajay , Ojha Saroj Prasad
Published: May 2021

Background

Mental and substance use disorders account for 30 % of the non-fatal disease burden and 10 % of the overall disease burden but the treatment gap is daunting. With just one psychiatrist per 200,000 populations in Nepal, the only convincing way to improve access to the services quickly is by mobilizing non-specialized medical practitioner. A robust mental health component within the training curriculum of general medical doctors could produce medical graduates with adequate knowledge and skills to deliver basic mental health service. We reviewed the mental health curricula for medical students of all the medical universities in Nepal.

Methods

Information on existing mental health curricula was collected from the faculty of the respective universities with respect to content coverage, teaching methods and evaluation patterns. The mental health curricula were described in relation to teaching duration, duration of clinical rotation, duration of internship, and the relative weight of mental health in examination marks. Teaching methods were classified broadly as passive and active. Assessment methods were documented. Content coverage of the curricula was evaluated with respect to history taking and general physical examination, the priority mental health conditions, topics on behavioural sciences, and child mental health or other topics.

Results

The duration of teaching on mental health in general medical doctor training in Nepalese medical universities ranges from 25 to 92 h. All medical universities have a relative focus on the priority mental neurological and substance use disorders. The clinical rotation on mental health is mostly two weeks, except in one university where it can be extended up to 4 weeks with an elective clinical rotation. The relative weight of summative assessment ranges from 0.21 to 2.5 % total marks of the entire training.

Conclusions

Considerable disparities exist in course content, teaching/learning modalities and assessments for mental health across Nepalese medical universities. The relative proportion of mental health in medical curricula as well as teaching/learning and assessments are far below ideal in these universities. These findings suggest a need for increasing time allocation, adopting newer teaching learning methods, and also having a mandatory clinical rotation during training and during internship.
A cross-case analyses of laboratory professionals-patients interaction for patients accessing laboratory services at University of Cape Coast hospital and Ewim Polyclinic in the Cape Coast Metropolis, Ghana
Authors: Adu Patrick
Published: May 2021

Background

There is scarcity of data on experiences of patients who access laboratory services during hospital visits in sub-Saharan Africa. This study sought to evaluate the depth of laboratory professionals-patient interactions during pre- and post-sampling period at two hospitals in Ghana.

Methods

This study used real time observations of patient-laboratory staff interactions to collect first-hand data. Additionally, two separate sets of semi-structured questionnaires were used to collect data on the experiences of patients and laboratory professionals. Data were entered into Microsoft Excel and analysed using SPSS version 25.

Results

Inadequate laboratory space is a major factor limiting adequacy of patients-laboratory professionals’ interactions. Overall, even though the laboratory professionals (93.3%) overwhelmingly agreed to the need to inform patients about the turnaround time of the respective laboratory testing, this was not routinely done. Irrespective of patients’ educational attainment, patients were poorly informed about their respective laboratory tests. Although both patients and laboratory professionals (60.0% vs 63.6% respectively) indicated that the test requester has responsibility to inform patients about their laboratory testing, only 29.1% of patients indicated having received such explanations. Furthermore, although 28.1% of patients indicated knowing the specifics of their respective test requisition, only 15% could correctly identify their requested laboratory testing.

Conclusion

There is the need for standard operating protocols to standardize practitioner-patient interaction at the two facilities. Moreover, there is the need for laboratory staff-test requester engagement to clearly delineate who has what responsibilities regarding informing patients about laboratory testing.
Exploring the influencing factors of quality of life among the empty nesters in Shanxi, China: a structural equation model
Authors: Zhang Chichen , Cai Yuan , Xue Yaqing , Zheng Xiao , Yang Xiaozhao , Lu Jiao , Hou Lihong , Li Mimi
Published: May 2021

Background

As China’s aging trend intensifies and the proportion of empty nests increases, the health-related quality of life of the elderly is the focus of social attention. Previous studies focused on the quality of life of the elderly, rather than empty nesters, and lacked the discussion of the mechanism of influencing factors. Thus, this study aimed to explore the influencing factors of the quality of life (QOL) and interaction mechanisms among empty nesters in Shanxi Province, China, so as to provide practical reference for improving the QOL of empty nesters.

Methods

A total of 4901 empty nesters in Shanxi Province, China, were selected using multi-stage random cluster sampling method in this cross-sectional study. The quality of life was assessed with the Short Form 36 Health Survey (SF-36). Multiple linear regression analysis (stepwise) was performed to examine the factor associated with QOL. Structural equation model (SEM) approach was conducted to test the direct and indirect association between QOL influencing factors with QOL.

Results

The average QOL score of empty nesters was 63.34 (SD = 17.23). The multiple linear regression revealed that gender, age, education, monthly income, drinking status, exercise frequency, physical examination frequency, attention to daily nutritional health, relationship with a spouse and relationship with children were significant predictors of the empty nester’s QOL (P < 0.05) (R2 = 0.128). SEM showed that behavioral lifestyle had a direct effect on QOL (β = 0.446, P < 0.001). Socio-economic status had an indirect effect (β = 0.288, P < 0.001) on QOL through behavioral lifestyle. The family relationship had an indirect effect (β = 0.115, P < 0.001) on QOL.

Conclusion

Behavioral lifestyle was the strongest influencing factor in the quality of life among empty nesters, followed by socio-economic status and family relationships. Thus, maintaining a healthy behavioral lifestyle was important to improve the QOL of the empty nesters. Our findings provide a concrete and strong reference for the formulation of targeted intervention strategies.
An investigation on chemical/mineral compositions, ruminal microbial fermentation, and feeding value of some leaves as alternative forages for finishing goats during the dry season
Authors: Kazemi Mohsen
Published: May 2021

Finding new fodder resources with moderate to high nutritional value that are cheaper and available is one of the most challenges in livestock industries. Hence, the nutritive value of some tree leaves (quince, pear, olive, mirabelle plum, greengage, sour cherry, and persimmon) was investigated by different laboratories and in vitro methods. Also, partial substitution of alfalfa and corn silage (50%) with these leaves was investigated using forty-eight goats in a randomized complete block design in vivo. Highest total phenol and tannin contents were obtained in quince (p < 0.001). Greengage (146.37 g/kg DM) and persimmon (136.96 g/kg DM) exhibited the highest crude protein, respectively (p < 0.001). Calcium content (19.82 g/kg DM) was highest in persimmon leaves (p < 0.001). Greengage (66.07 mmol/L) and mirabelle plum (65.58 mmol/L) produced more total volatile fatty acids in the culture medium, respectively (p < 0.001). Potential gas production ranged from 39.65 mL for pear to 55.32 mL mirabelle plum. Sour cherry had the highest acid–base buffering capacity (183.73 mEq × 10–3,p < 0.001). Highest dry matter intake (1087 g/day) and crude protein digestibility (70.80 %) were observed in diets containing greengage (p < 0.001). Total antioxidant capacity of serum increased when olive, quince, and persimmon were considered in goats feeding (p < 0.001). Although all studied leaves can be fed in diets of goats without deleterious effects on performance, serum, and hematology parameters, in vivo and in vitro results indicated that greengage in terms of nutritive value was superior to other studied leaves.
Evidence on collaboration of traditional and biomedical practitioners in the management of antimicrobial resistance in sub-Saharan Africa over 15 years: a systematic review protocol
Authors: Mushebenge Aganze Gloire-Aimé , Kadima Mukanda Gedeon , Mashamba-Thompson Tivani , Nlooto Manimbulu
Published: May 2021

Background

The overuse of prescribed antimicrobials, concurrent use of traditional medicine, and prescribed antimicrobials have led to antimicrobial resistance. The absence of collaboration between traditional health practitioners and biomedically trained healthcare professionals can contribute to antimicrobial resistance, treatment failure, overdose, toxicity, and misadministration. This scoping review explores the evidence on collaboration between traditional health practitioners and biomedically trained healthcare professionals to reduce antimicrobial resistance and treatment failure in bacterial and viral diseases.

Methods

We will search for electronic databases such as Science Direct, Google Scholar, PubMed, and MEDLINE via EBSCOhost. We will also search reference lists of included studies. A two-stage mapping procedure will be carried out. Stage one (1) will consist of the title, abstracts, and full article screening, respectively. A pilot screening form guided by the defined eligibility criteria will be used. In stage two (2), data will be extracted from the included studies. Two reviewers will conduct parallel screening and data extraction. Mixed methods appraisal tool (MMAT) will be used to assess the quality of the included studies. NVIVO version 11 will be employed to aid pertinent thematic analysis. The outcomes of interest will be as follows: Primary outcome will be preventing and reducing antimicrobial resistance. The secondary effect is the effective collaboration between traditional healthcare practitioners and biomedically healthcare professionals.

Discussion

This review anticipates uncovering pertinent publications reporting the evidence of collaboration between traditional health practitioners and biomedically trained healthcare professionals to reduce antimicrobial resistance in sub-Saharan Africa. The sum-up of evidence acquired from the included studies will help guide future research. The result of the study will be print and electronically exposed.

Systematic review registration

PROSPERO, CRD42017072952
Colors and dyes of archaeological textiles from Tarapacá in the Atacama Desert (South Central Andes)
Authors: Sepúlveda Marcela , Lemp Urzúa Cecilia , Cárcamo-Vega José , Casanova-Gónzalez Edgar , Gutiérrez Sebastián , Maynez-Rojas Miguel Ángel , Ballester Benjamín , Ruvalcaba-Sil José Luis
Published: May 2021

This work concerns the study of colors and dyes identified on archaeological textiles from the Atacama Desert. The different garments and ornaments come from the excavation of two important pre-Columbian cemeteries of the Tarapacá region: Tarapacá-40 attributed to the Formative period (1100 BC–660 AD) and Pica-8 to the Late Intermediate period (900–1450 AD). For the first time, a multi-analytical approach with non-invasive techniques using FORS and SERS was applied on samples of less than 2 cm of length for physicochemical characterization of the raw materials and the dyes employed in the textile production of northern Chile. The fibers are from animal origin. Blue, green, and yellow are identified as indigo, but we cannot discard a mixture with other dyes to vary hue and shade; while carminic acid and alizarin—to a lesser extent—are found on red, orange, and brown samples. This research provides new elements for the discussion about the textile technology developed in this desertic region, its changes, and continuities along the history. Our results are compared to recent findings on neighboring regions from South-Central Andes, to improve the current knowledge and discuss the existence of dyeing textile cultural traditions.
The dark-ventral-patch of male red deer, a sexual signal that conveys the degree of involvement in rutting behavior
Authors: de la Peña Eva , Pérez-González Javier , Martín José , Vedel Giovanni , Carranza Juan
Published: May 2021

Background

In polygynous mammals, signalling may play a decisive role in mating behavior, mediating the intensity of male fights and female mate choice. During the rutting season, male red deer may show a visible dark patch in their ventral fur. Recently, this patch has been suggested to act as a flexible sexual signal, due to its relationships with other variables such as age, body size, antler development, volatile compounds, or the competitive environment. The analysis of fur pigmentation at the ventral patch suggests that this might also visually indicate the male intrinsic predisposition to take part in mating competition.

Results

To assess the possible role of this trait as a communicative signal related to mate competition, we used red deer behavioral observations during the rut in Doñana National Park (Spain) to examine the link between the degree of expression of the dark ventral patch and the rutting activity (assessed from both intra-and-inter-sexual behaviors). Consistent with our predictions, we found in a field study that males with large dark patches showed a higher frequency of rutting behaviors (mainly roaring and flehmen), more interactions with females, and attained larger harem sizes.

Conclusions

The dark ventral patch was a better predictor of male behavior than antler tines or territory holding, thus standing as a short-term indicator of male willingness to invest in mating competition.
The effect of two educational technology tools on student engagement in Chinese EFL courses
Authors: Teng Yilian , Wang Xia
Published: May 2021

Educational technology has become an indispensable aspect of higher education, playing a crucial role in affecting student engagement, in particular. The application, advantages and disadvantages of learning management systems (LMS) and social networking systems in Chinese EFL courses, represented by Superstar—Xuexitong and WeChat, are introduced. The study aims to explore the relationship between the two educational technology tools and three dimensions of student engagement. Using an adopted and revised questionnaire from previous researches, the study measures the extent of impact of the specified educational technology tools on student engagement with the help of SPSS. Through the independent sample T tests, analysis of variance, correlation and regression, the study found that emotional engagement has the strongest positive effect on educational technology engagement. In addition, analysis of the four principal factors indicates that using LMS could engage students more than adopting social networking systems. There are significant differences in cognitive engagement between different genders, with that of males surpassing females. This article provides some empirical evidence for exploration into the use of educational technology in a specific discipline to foster better student engagement.
Material decomposition using iodine quantification on spectral CT for characterising nodules in the cirrhotic liver: a retrospective study
Authors: Laroia Shalini Thapar , Yadav Komal , Kumar Senthil , Rastogi Archana , Kumar Guresh , Sarin Shiv Kumar
Published: May 2021

Background

There is limited scientific evidence on the potential of spectral computed tomography (SCT) for differentiation of nodules in the cirrhotic liver. We aimed to assess SCT-generated material density (MD) parameters for nodule characterisation in cirrhosis.

Methods

Dynamic dual-energy SCT scans of cirrhotic patients performed over 3 years were retrospectively reviewed. They were classified as hepatocellular carcinoma (HCC), regenerative or indeterminate, according to the European Association for the Study of the Liver criteria. MD maps were generated to calculate the area under the curve (AUC) and cutoff values to discriminate these nodules in the hepatic arterial phase (HAP) and portal venous phase (PVP). MD maps included iodine concentration density (ICD) of the liver and nodule, lesion-to-normal liver ICD ratio (LNR) and difference in nodule ICD between HAP and PVP.

Results

Three hundred thirty nodules belonging to 300 patients (age 53.0 ± 12.7 years, mean ± standard deviation) were analysed at SCT (size 2.3 ± 0.8 cm, mean ± SD). One hundred thirty-three (40.3%) nodules were classified as HCC, 147 (44.5%) as regenerative and 50 (15.2%) as indeterminate. On histopathology, 136 (41.2%) nodules were classified as HCC, 183 (55.5%) as regenerative and 11 (3.3%) as dysplastic. All MD parameters on HAP and the nodule  difference in ICD could discriminate pathologically proven HCC or potentially malignant nodules from regenerative nodules (p < 0.001). The AUC was 82.4% with a cutoff > 15.5 mg/mL for nodule ICD, 81.3% > 1.8 for LNR-HAP and 81.3% for difference in ICD > 3.5 mg/mL.

Conclusion

SCT-generated MD parameters are viable diagnostic tools for differentiating malignant or potentially malignant from benign nodules in the cirrhotic liver.
Effect of the combination of Leptadenia hastata (pers) decne and Momordica balsamina linn leaf extracts on lipid profile of streptozotocin-induced diabetic rats
Authors: Kabir Nafisatu , Alhaji Umar Ismail , James Dorcas Bolanle , Inuwa Hajia Mairo , Atiku Muhammad Kano
Published: May 2021

Background

Changes in blood lipid level (dyslipidemia) play a central role in the onset and pathogenesis of macrovascular complications of diabetes mellitus. Traditional herbal healers commonly use anti-diabetic polyherbal formulations to provide a multi-therapeutic approach for the treatment of diabetes mellitus and its associated complications. The effect of the aqueous leaf extracts of Leptadenia hastata (pers) Decne, Momordica balsamina Linn and their combination on lipid profile of streptozotocin (STZ)-induced diabetic rats was therefore evaluated in the present study.

Results

We evaluated the serum lipid profile and blood glucose level of STZ-induced diabetic rats (60 mg/kg body weight) treated with the aqueous leaf extracts of L. hastata (400 mg/kg) and M. balsamina (200 mg/kg) alone and in combination (400 + 200 mg/kg) after a period of 4 weeks. A significantly decreased (p < 0.05) level of total cholesterol (TC), triglyceride (TG), very low-density lipoprotein (VLDL) and low-density lipoprotein (LDL) cholesterol levels and increased (p < 0.05) level of high-density lipoprotein (HDL) cholesterol was observed in all the treated groups when compared to the untreated diabetic rats. Furthermore, the combination treatment was potentially a more effective blood lipid-lowering (p < 0.05) agent when compared to the single treatments.

Conclusion

Results from this study demonstrated the blood lipid-lowering potential of the aqueous leaf extracts of L. hastata, M. balsamina, and their combination. However, the polyherbal combination could be more potent in controlling diabetes mellitus, associated dyslipidemia, and its complications.