bluuebunny/crossref_metadata_2025 huggingface dataset:
Contrast-Enhanced Cone-Beam Breast CT: An Analysis of Diagnostic Value in Predicting Breast Lesion With Rim Enhancement Malignancy
Authors: Zhao Xin , Yang Jun , Zuo Yang , Kang Wei , Liao Hai , Zheng Zhong-Tao , Su Dan-Ke
Published: May 2022

Background

The objective of the current study was to investigate the diagnostic value of contrast-enhanced cone-beam breast computed tomography (CE-CBBCT) for breast lesion with rim enhancement (RE).

Methods

All 36 patients were examined by non-contrast (NC-CBBCT) and contrast-enhanced CBBCT (CE-CBBCT) after contrast media (CM) injection. Qualitative morphological enhancement parameters and quantitative enhancement parameters were compared between malignant and benign groups. Multivariable logistic regression analysis was performed to identify independent factors that could predict breast lesion with RE malignancy. Receiver operating curve (ROC) was used to evaluate prediction performance.

Results

A total of 36 patients with 40 lesions underwent breast CE-CBBCT were enrolled. There were significant differences in most qualitative morphological enhancement parameters between the two groups. A multivariate logistic regression model showed that △standardized HU (INRphase 2−INRpreCM) [odds ratio (OR) = 1.148, 95% CI = 1.034–1.276, p = 0.01] and △standardized HU (RPphase 2 − RPphase 1) (OR = 0.891, 95% CI = 0.814–0.976, p = 0.013) were independent indicators in predicting breast lesion with RE malignancy. △standardized HU (INRphase 2 − INRpreCM) combined with △standardized HU (RPphase 2 − RPphase 1) showed significant larger area under the receiver operating curve (AUC) and higher sensitivity than each alone (p < 0.001, AUC = 0.932, sensitivity = 92.59%, specificity = 92.31%). The regression equation of the prediction model was as follows: Logit (p) = 0.351 + 0.138X × △standardized HU (INRphase 2 − INRpreCM) − 0.115 × △standardized HU (RPphase 2 − RPphase 1).

Conclusion

With the observation of qualitative morphological enhancement parameters and the comparison of quantitative enhancement parameters of CBBCT, a reliable basis for the diagnostic accuracy in predicting breast lesion with RE could be provided. These conclusions should be verified in large, well-designed studies.
Case Report: Long-Term Treatment and Follow-Up of Kleefstra Syndrome-2
Authors: Wu Dandan , Li Rong
Published: May 2022

Background

Mutations in the KMT2C gene can cause Kleefstra syndrome-2 (KLEFS2).

Case

In this study, we analyzed the clinical, genetic testing, and 10-year follow-up data of a child with KLEFS2 treated at the Child Healthcare Department, Children's Hospital of Nanjing Medical University, Nanjing. The case of KLEFS2 presented feeding difficulty and developmental delay, both intervened by nutritional support and family rehabilitation. Obvious attention deficit hyperactivity disorder (ADHD) occurred in preschool and school-age children and was managed by behavioral and pharmaceutical interventions.

Conclusion

Features of KLEFS2 include feeding difficulty and developmental delays in an early age, as well as ADHD in preschool and school age. Satisfactory outcomes are not achieved in early nutritional support for correcting malnutrition and pharmaceutical intervention for relieving ADHD, but both measures can counter developmental delay.
Pathogenicity and Long-Term Outcomes of Liddle Syndrome Caused by a Nonsense Mutation of SCNN1G in a Chinese Family
Authors: Zhang Di , Qu Yi , Dong Xue-Qi , Lu Yi-Ting , Yang Kun-Qi , Liu Xin-Chang , Fan Peng , Hu Yu-Xiao , Yang Chun-Xue , Gao Ling-Gen , Liu Ya-Xin , Zhou Xian-Liang
Published: May 2022

Objective

Liddle syndrome (LS) is a monogenic hypertension consistent with autosomal dominant inheritance, often with early onset high blood pressure in childhood or adolescence. This study aimed to identify the pathogenicity of a nonsense mutation in SCNN1G in a Chinese family with LS and the long-term outcomes of tailored treatment with amiloride.

Methods

To explore the pathogenicity of candidate variant reported in 2015 by our team, we constructed mutant and wild-type models in vitro and measured amiloride-sensitive current in Chinese Hamster Ovary (CHO) cells using patch clamp technique. Participants were followed up for 7 years after tailored treatment with amiloride.

Results

A nonsense variant was detected in six members, two of whom were pediatric patients. This mutation resulted in a termination codon at codon 572, truncating the Pro-Pro-Pro-X-Tyr motif. The mutant epithelial sodium channels displayed higher amiloride-sensitive currents than the wild-type channels (P < 0.05). Tailored treatment with amiloride achieved ideal blood pressure control in all patients with normal cardiorenal function, and no adverse events occurred during follow-up.

Conclusion

We found the pathogenicity of a nonsense SCNN1G mutation (p.Glu571*) with enhanced amiloride-sensitive currents in a LS family with young patients. Tailored treatment with amiloride may be an effective strategy for the long-term control of blood pressure and protection from target organ damage or cardiovascular events, including children and youth patients with LS.
Neuromuscular Blockade for Cardiac Arrest Patients Treated With Targeted Temperature Management: A Systematic Review and Meta-Analysis
Authors: Lin Tong , Yao Yan , Xu Yuan , Huang Hui-Bin
Published: May 2022

Background: Neuromuscular-blocking agents (NMBA) are often administered to control shivering in comatose cardiac arrest (CA) survivors during targeted temperature management (TTM) management. Thus, we performed a systematic review and meta-analysis to investigate the effectiveness and safety of NMBA in such a patient population.

Methods: We searched for relevant studies in PubMed, Embase, and the Cochrane Library until 15 Jul 2021. Studies were included if they reported data on any of the predefined outcomes in adult comatose CA survivors managed with any NMBA regimens. The primary outcomes were mortality and neurological outcome. Results were expressed as odds ratio (OR) or mean difference (MD) with an accompanying 95% confidence interval (CI). Heterogeneity, sensitivity analysis, and publication bias were also investigated to test the robustness of the primary outcome.

Data Synthesis: We included 12 studies (3 randomized controlled trials and nine observational studies) enrolling 11,317 patients. These studies used NMBA in three strategies: prophylactic NMBA, bolus NMBA if demanded, or managed without NMBA. Pooled analysis showed that CA survivors with prophylactic NMBA significantly improved both outcomes of mortality (OR 0.74; 95% CI 0.64–0.86; I2 = 41%; p < 0.0001) and neurological outcome (OR 0.53; 95% CI 0.37–0.78; I2 = 59%; p = 0.001) than those managed without NMBA. These results were confirmed by the sensitivity analyses and subgroup analyses. Only a few studies compared CA survivors receiving continuous versus bolus NMBA if demanded strategies and the pooled results showed no benefit in the primary outcomes between the two groups.

Conclusion: Our results showed that using prophylactic NMBA strategy compared to the absence of NMBA was associated with improved mortality and neurologic outcome in CA patients undergoing TTM. However, more high-quality randomized controlled trials are needed to confirm our results.
The Evasion Mechanisms of Cancer Immunity and Drug Intervention in the Tumor Microenvironment
Authors: Kim Seong Keun , Cho Sun Wook
Published: May 2022

Recently, in the field of cancer treatment, the paradigm has changed to immunotherapy that activates the immune system to induce cancer attacks. Among them, immune checkpoint inhibitors (ICI) are attracting attention as excellent and continuous clinical results. However, it shows not only limitations such as efficacy only in some patients or some indications, but also side-effects and resistance occur. Therefore, it is necessary to understand the factors of the tumor microenvironment (TME) that affect the efficacy of immunotherapy, that is, the mechanism by which cancer grows while evading or suppressing attacks from the immune system within the TME. Tumors can evade attacks from the immune system through various mechanisms such as restricting antigen recognition, inhibiting the immune system, and inducing T cell exhaustion. In addition, tumors inhibit or evade the immune system by accumulating specific metabolites and signal factors within the TME or limiting the nutrients available to immune cells. In order to overcome the limitations of immunotherapy and develop effective cancer treatments and therapeutic strategies, an approach is needed to understand the functions of cancer and immune cells in an integrated manner based on the TME. In this review, we will examine the effects of the TME on cancer cells and immune cells, especially how cancer cells evade the immune system, and examine anti-cancer strategies based on TME.
Physiological Regulation of Growth, Hematology and Blood Gases in Chicken Embryos in Response to Low and High Incubation Humidity
Authors: Branum Sylvia , Tazawa Hiroshi , Burggren Warren
Published: May 2022

Variations from a relative humidity (RH) of ∼50–60% can unfavorably alter chicken embryo development, but little is known of whether the embryo can mitigate these effects through physiological regulation. We examined effects of Low RH (25–35%), and High RH (85–93%) compared to Control RH (50–60%) on hatchability, embryonic growth, hematology and blood gases and pH. Mean hatchability was not affected by RH. Yet, Low RH decreased wet body mass of advanced embryos (days 17–19; d17-19), with lowered body water content compared with embryos of Control and High RH. However, dry body mass of developing (d11-19) embryos was not different between the three RH groups. Mean blood osmolality across development was higher in Low RH embryos and lower in High RH embryos compared with Control embryos. Mean blood lactate was higher in both Low and High RH embryos compared to Control embryos. Unexpectedly, hematological respiratory variables (Hct, [RBC], MCV, [Hb]) and blood gas variables (Po2, Pco2, pH, [HCO3−]) across development were not affected by RH. Mean wet body mass at hatch (d20-22) was larger in High RH embryos compared with Low RH embryos, but mean wet and dry body mass upon euthanasia on d22 was unaffected. The ability of the three populations to physiologically regulate blood respiratory variables and blood acid-base balance was then examined by observing their responses to intrinsic hypoxemia and hypercapnia created by controlled partial egg submersion in water. Hct and [RBC] responses were less disturbed by submersion in High RH embryos compared with both Control and Low RH embryos, which showed major disturbance. Acid-base regulatory responses did not differ between RH groups. We conclude that, while different incubation RHs cause large differences in tissue water content and body mass, most hematological and acid-base regulatory capabilities are regulated near Control values.
Crop Species Mechanisms and Ecosystem Services for Sustainable Forage Cropping Systems in Salt-Affected Arid Regions
Authors: Ashilenje Dennis S. , Amombo Erick , Hirich Abdelaziz , Kouisni Lamfeddal , Devkota Krishna P. , El Mouttaqi Ayoub , Nilahyane Abdelaziz
Published: May 2022

Soil salinity limits crop productivity in arid regions and it can be alleviated by crop synergies. A multivariate analysis of published data (n = 78) from arid and semiarid habitats across continents was conducted to determine the crop species mechanisms of salinity tolerance and synergies relevant for designing adapted forage cropping systems. Halophyte [Cynodon plectostachus (K. Schum.) Pilg.] and non-halophyte grasses (Lolium perenne L. and Panicum maximum Jacq.) clustered along increasing soil salinity. Halophytic grasses [Panicum antidotale Retz. and Dicanthum annulatum (Forssk.) Stapf] congregated with Medicago sativa L., a non-halophytic legume along a gradient of increasing photosynthesis. Halophytic grasses [Sporobolus spicatus (Vahl) Kunth, and Cynodon plectostachyus (K. Schum.) Pilg.] had strong yield-salinity correlations. Medicago sativa L. and Leptochloa fusca L. Kunth were ubiquitous in their forage biomass production along a continuum of medium to high salinity. Forage crude protein was strongly correlated with increasing salinity in halophytic grasses and non-halophytic legumes. Halophytes were identified with mechanisms to neutralize the soil sodium accumulation and forage productivity along an increasing salinity. Overall, halophytes-non-halophytes, grass-forbs, annual-perennials, and plant-bacteria-fungi synergies were identified which can potentially form cropping systems that can ameliorate saline soils and sustain forage productivity in salt-affected arid regions.
The Influence of Innovation Climate on Creative Role Identity: The Mediating Role of Flow
Authors: Deng Baijun , Cao Jijuan , Huang Jieqi , Wu Jun
Published: May 2022

Creative role identity is an important antecedent of innovative behaviors. Both the mechanism of how external factors and individual factors affect the formation of creative role identity and details of this process have yet to be discovered. Based on data collected from 226 students in 6 classes at a university in Guangdong during the development of innovative projects, the influence of innovation climate on the students’ creative role identity, especially the mediating effect of flow, was investigated. The results show that the innovation climate has a positive impact on creative role identity and that flow plays a partial mediating role in this relationship.
Case Report: Spontaneous Fetal Demises at Third Trimester of Pregnancy Due to a Double Lopped Nuchal Cord in Camelus dromedarius
Authors: Son Young-Bum , Hossein Mohammad Shamim , Yu Xianfeng , Jeong Yeon Ik , Olsson P. Olof , Hwang Woo Suk
Published: May 2022

The umbilical cord acts as the critical lifeline of the developing fetus by providing nutrients and oxygen to it. Umbilical cord abnormalities are considered the leading cause of stillbirth in humans, but information on stillbirths associated with umbilical cord abnormalities is very scant in the clinical practice of animals. Here, we described a case of fetal demise in camels indicated to be caused by fetal death from strangulation by its umbilical cord, which is commonly known as the nuchal cord. A pregnant camel at its 36 weeks of gestation spontaneously aborted a single fetus. The camel was 5 years old and nullipara. A 6-day-old cloned embryo was transferred transcervically to the recipient. Pregnancy was confirmed 50 days after embryo transfer by ultrasonography, and the pregnant camel was maintained under a standard nutritional plan. The neck of the aborted fetus was strangulated tightly by a double loop of the umbilical cord. There was no congenital anomaly or other malformation in the fetus. We concluded that the nuchal cord was tightly coiled around the neck of the fetus and interfered with the blood flow in the fetus by collapsing the umbilical vein and subsequently causing fetal death and abortion. To the authors' knowledge, this is the first reported case of a nuchal cord in camels.
A Qualitative Study of Antibiotic Use Practices in Intensive Small-Scale Farming in Urban and Peri-Urban Blantyre, Malawi: Implications for Antimicrobial Resistance
Authors: Mankhomwa John , Tolhurst Rachel , M'biya Eunice , Chikowe Ibrahim , Banda Pemphero , Mussa Jimmy , Mwasikakata Henry , Simpson Victoria , Feasey Nicholas , MacPherson Eleanor E.
Published: May 2022

The routine use of antimicrobials in meat production has been identified as a driver of antimicrobial resistance (AMR) in both animals and humans. Significant knowledge gaps exist on antibiotic use practices in farming, particularly in sub-Saharan Africa. This paper sought to generate in-depth understanding of household antibiotic use practices in food animals in urban- and peri-urban Blantyre. We used a qualitative research methodology focusing on households that kept scavenging animals and those engaged in small-scale intensive farming of food animals. Methods used were: medicine-use surveys with 130 conducted with a range of households; in-depth interviews (32) with a range of participants including farmers, community based veterinary health workers and veterinary shop workers; and stakeholder interviews (17) with policy makers, regulators, and academics. Six months of ethnographic fieldwork was also undertaken, with households engaged in farming, veterinary officers and veterinary stores. Our findings suggest antibiotic use in animals was more common in households that used small-scale intensive farming techniques, but rare in households that did not. For farmers engaged in small-scale intensive farming, antibiotics were often considered vital to remain solvent in a precarious economic and social environment, with limited access to veterinary services. A complex regulatory framework governed the import, prescription, and administration of antibiotics. Veterinary stores provided easy access to antibiotics, including colistin, an antibiotic on the WHO's critically important antibiotics for human health. Our work suggests that the high dependence on antibiotics for small-scale intensive farming may contribute to the growth of drug resistant infections in Malawi. The socio-economic drivers of antibiotic use mean that interventions need to take a holistic approach to address the high dependence on antibiotics. Key interventions could include improving farmers' access to affordable veterinary services, providing information about appropriate antibiotic use including withdrawal periods and feed supplementation, as well as improvements in regulation (nationally and internationally) and enforcement of current regulations. Taken together these approaches could lead to antibiotic use being optimised in feed animals.
The Relationship between Hydrophobicity and Drug-Protein Binding in Human Serum Albumin: A Quartz Crystal Microbalance Study
Authors: Alhankawi Ahmad R. , Al-Husseini Jacob K. , Spindler Archie , Baker Clark , Shoniwa Tonderai T. , Ahmed Mohammed , Chiarelli Peter A. , Johal Malkiat S.
Published: May 2022

In this paper, the quartz crystal microbalance with dissipation monitoring (QCM-D) was used to investigate hydrophobicity and binding strength (KD) for 10 different drugs interacting with human serum albumin (HSA). Quantitative structure activity relationship (QSAR) analysis was used to determine the relationship between drug hydrophobicity (ClogP) and HSA binding strength log(1/KD). The results are compared to prior knowledge on bovine serum albumin (BSA) binding. We demonstrate a positive correlation between drug hydrophobicity and the strength of ligand-protein binding to HSA and show a statistically significant similarity with the trend reported in BSA. The findings presented in this work provide insight into the role that bound water plays in ligand-protein interactions. Further, the comparison between HSA and BSA provides quantitative justification for the use of these proteins interchangeably in the analysis of drug-based binding kinetics.
Design Thinking Applied to Home Textiles Innovation: A Case Study in an Elderly Centre in Hong Kong
Authors: Yao Meiyu , Li Li
Published: May 2022

The ageing society is a challenging social issue, yet it implies a growing demand for elderly goods and services. The current development of elderly textile products, however, appears to neglect everyday use. This paper used a case study to demonstrate the utilization of design thinking, a human-centric methodology, in order to design and develop a creative solution for elderly care in elderly centers, taking into account their needs and preferences with regard to textiles. Starting from empathy, complex problems were identified, and ideas were generated. As a skin-protective home textile, chitosan, a natural antibacterial material, has been suggested for development. By using iterative processes, the spinning problem was tackled; the biological and physical characteristics were studied; design, sizing, patterns and printing were created and refined to fulfill the needs; mass production of bedding, apron and handkerchief were successfully achieved; a pre-posttest trial was conducted to determine the satisfaction level and potential help of the prototypes. The feedback was generally positive and highly satisfied. Hence, this study indicates that the design thinking approach may provide an effective method of understanding empathy and discovering solutions most likely to meet the needs of the users.
Online Feedback Systems and Debate on Scientific Issues during COVID-19: A Case Study on Sookmyung Women’s University
Authors: Kim Ji-yoon , Shim Min-kyeong , Hwang Young-mee
Published: May 2022

As the COVID-19 pandemic continues, university education and feedback guidance have inevitably moved to online platforms, becoming a global trend. This study focuses on a case of Sookmyung Women’s University in South Korea, which has operated an online discussion clinic for university general education for more than a year as a case study. There are two main research methods. A frequency analysis was conducted to confirm what kind of counseling the students preferred at the discussion clinic based on the answers written in the students’ applications. The students whose applications were used for the analysis were divided into 57 teams, and there were two to six members per team. The results were as follows: In the survey results, students wanted help with the preparation process necessary for the discussion and the practical strategies for facilitating discussions. They wanted personalized counseling, demonstrating that discussion education provided in the foundational curriculum is insufficient. Second, the educational model of the discussion clinic and educational examples were examined. The findings confirmed that online discussion education is effective if the system is technically supplemented. Instructors and researchers are prepared to meet students’ demands for feedback and individual counseling, even if these are not provided through face-to-face discussions. Additionally, face-to-face guidance can be operated more effectively by taking advantage of online systems. The findings also demonstrate that further research on designing and operating online discussion centers is required. This study is a preceding study on developing online systems and educational guidelines for higher educational institutions to present new insights into smart learning. This paper also includes suggestions for educational and scientific discussions. The online discussion instructional model shown in this paper explores methods of scientific communication through a debate on scientific issues.
Soil Characteristics in Private Gardens of Different City Neighborhoods: A Case Study of Taibe, Israel
Authors: Sarah Pariente , Zhevelev Helena , Haj-Yehia Shatha , Sachs Eyal , Fragin Anatoly G.
Published: May 2022

City green areas including private gardens, provide ecological, sociological, cultural, health, and engineering advantages that motivate the urban system. Manmade impacts on the development of urban soils are of greater importance than natural ones. Soil properties were studied in an Arab city—Taibe—in Israel. Two neighborhoods in the city, which differed in time of establishment, were selected: An older residential neighborhood constructed more than 70 years ago, and a newer one built 10 years ago. In each neighborhood, 15 private gardens were randomly chosen. In total, the study was conducted in 30 gardens. In each garden, soil samples were collected from three depths: 0–2, 2–10, and 10–30 cm, respectively. In each sample, organic matter, hygroscopic moisture, calcium carbonate, bulk density, field water content, lead, copper and zinc contents, and texture were determined. The soil of the older neighborhood expressed greater values of soil properties and higher profile differentiation than the newer one. The heavy metals in the soil of the private gardens of both neighborhoods are not present in excess nor are they toxic. Under the prevailing environmental conditions, the soil of the newer neighborhood will become like that of the older one in the future unless a new soil interruption occurs. The calcium carbonate and heavy metals contents in the soil can be used as indicators of soil maturity in different areas of the city having similar environmental conditions. In addition, the gradients of these properties along profiles can be helpful in restoring the history of human activity, which prevailed in the area.
Comment on Scheepers et al. Comparative Performance Testing of Respirator versus Surgical Mask Using a Water Droplet Spray Model. Int. J. Environ. Res. Public Health 2021, 18, 1599
Authors: Viner Andrew , Ayrey Stewart
Published: May 2022

In the article “Comparative Performance Testing of Respirator versus Surgical Mask Using a Water Droplet Spray Model” by Scheepers et al. [...]
Portfolio Optimization on Multivariate Regime-Switching GARCH Model with Normal Tempered Stable Innovation
Authors: Peng Cheng , Kim Young Shin , Mittnik Stefan
Published: May 2022

This paper uses simulation-based portfolio optimization to mitigate the left tail risk of the portfolio. The contribution is twofold. (i) We propose the Markov regime-switching GARCH model with multivariate normal tempered stable innovation (MRS-MNTS-GARCH) to accommodate fat tails, volatility clustering and regime switch. The volatility of each asset independently follows the regime-switch GARCH model, while the correlation of joint innovation of the GARCH models follows the Hidden Markov Model. (ii) We use tail risk measures, namely conditional value-at-risk (CVaR) and conditional drawdown-at-risk (CDaR), in the portfolio optimization. The optimization is performed with the sample paths simulated by the MRS-MNTS-GARCH model. We conduct an empirical study on the performance of optimal portfolios. Out-of-sample tests show that the optimal portfolios with tail measures outperform the optimal portfolio with standard deviation measure and the equally weighted portfolio in various performance measures. The out-of-sample performance of the optimal portfolios is also more robust to suboptimality on the efficient frontier.
Adenoma-Derived Organoids for Precision Therapy
Authors: Evron-Levy Tamar , Caspi Michal , Wittenstein Amnon , Shorer-Arbel Yamit , Shomron Olga , Hirschberg Koret , Kariv Revital , Rosin-Arbesfeld Rina
Published: May 2022

Human colonic organoids derived from adult tissue biopsies are based on the ability of isolated somatic epithelial stem cells to reconstitute the structure and function of the colon, offering new opportunities for studying the biology of the large intestine in both health and disease. These colonoids may also function as efficient platforms for drug screening and discovery. Here, we describe the establishment of human colonic organoids derived from healthy, and adenomatous polyp tissues. We then demonstrate that organoids grown from adenomas of familial adenomatous polyposis (FAP) patients harboring nonsense mutations in the tumor suppressor gene adenomatous polyposis coli (APC), can be used to establish a personalized therapeutic strategy which relies on nonsense mutation readthrough therapy.
Importancia del liderazgo directivo en la gestión del estrés ocupacional en un gobierno local
Authors: Abad Alvarez Sandy Yuvicsa , Camacuari Callupe Yanina Donata , De La Cruz Vargas Alexander David
Published: May 2022

El  manejo  del  estrés   ocupacional   es un problema que afecta a las organizaciones, porque influye  sobre  el desempeño de los trabajadores, afectando   el   clima    y    decayendo la productividad, de ahí que  se  necesite la figura del líder que pueda mejor la situación problemática e  influya positivamente sobre el clima organizacional.    De    esta    manera, la investigación se desarrolla en la descripción de cómo el liderazgo directivo resulta importante e  influye  en la gestión del estrés ocupacional en los trabajadores de la Municipalidad Distrital Cristo Nos Valga – Piura. La realización de investigación descriptiva parte de uso de la metodología cuantitativa y cualitativa, de corte transversal, haciendo uso de la técnica de  encuesta.  Además,  la  población  y muestra está conformada por 112 trabajadores administrativos. Finalmente, los resultados mostraron que existe una relación directamente proporcional entre el  liderazgo directivo y el estrés ocupacional de los trabajadores de la Municipalidad Cristo Nos Valga de Piura.
Comunidades de práctica, pasos para su implementación
Authors: Mendoza Yépez Yolanda Alexandra , Torres María Francisca , Sarmiento Germania
Published: May 2022

Las  comunidades  de  práctica  han sido  reconocidas  como  un  activo intangible  muy  valioso  dentro  de la  gestión  empresarial,  de  ahí  que las   mejores   organizaciones   del mundo   están   destinando   tiempo y  recursos  al  diseño,  implantación y   mantenimiento   de   estas.   Las Comunidades de Práctica son redes sociales  dinámicas  y  flexibles.  El objetivo fue analizar los hallazgos en  cuanto  al  proceso  que  debe cumplir  una  comunidad  práctica. El  diseño  se  basó  en  la  búsqueda de bibliografía de diversos autores como fuentes para la descripción de los  puntos  desarrollados  sobre  las comunidades de prácticas y gestión del conocimiento. De esta manera, las   comunidades   de   práctica   se convierten  en  un  concepto  clave como   unidad   básica   de   análisis, especialmente en las empresas que requieren  y  poseen  gran  cantidad de conocimiento.
Gestión para la simplificación administrativa en trámites académicos en la Universidad Nacional Toribio Rodríguez de Mendoza
Authors: Rojas Paico Jessica Noemí
Published: May 2022

La simplificación administrativa en los trámites  académicos  es  un  reto  que asume la universidad nacional Toribio Rodríguez  de  Mendoza,  en  eliminar obstáculos    o    costos    innecesarios para    la    comunidad    universitaria que      generan      el      inadecuado funcionamiento de la administración pública;  relacionado  a  la  calidad  de atención. Es por ello, que el propósito del estudio fue diagnosticar el proceso de      simplificación      administrativa en    los    trámites    académicos    de la    Universidad    Nacional    Toribio Rodríguez de Mendoza de Amazonas. Para ello se basó en la metodología de tipo básica descriptiva de enfoque cuantitativa,    con    un    diseño    no experimental   de   corte   transversal, asimismo  se  usó  una  muestra  con un   muestreo   probabilístico   simple con  una  unidad  de  análisis  de  349 estudiantes.   Se   aplicó   la   técnica de  la  encuesta,  con  el  instrumento del    cuestionario.    Obteniendo    un resultado   de   valoración   de   36,1% de  nivel  baja,  34,4%  de  nivel  media y  por  último  de  29,5%  de  nivel  alta. Por  lo  tanto,  se  concluye  que  existe una     simplificación     administrativa con tiempos de atención significando que  la  atención,  los  trámites  y  los procedimientos  administrativos  que se utilizan no han logrado satisfacer a los usuarios.
Simplificación administrativa para la satisfacción del usuario de la municipalidad
Authors: Villanueva Coico Guillermo Ricardo , Perez Astonitas Nelba , Flores Carrero Juan Rubén
Published: May 2022

La satisfacción del usuario es un indicador de  calidad  de  atención  prestada  en  las instituciones   públicas,   en   la   cual   esta permite   mejorar   todas   las   falencias   y reafirmar   fortalezas;   sin   embargo,   la Municipalidad   distrital   de   Jayanca   ha sido  cuestionada  en  varias  ocasiones  y la  mayoría  de  las  veces  los  usuarios  se encuentran  insatisfechos  con  el  servicio brindado, debido a una deficiente gestión en   la   planificación   de   estrategias   que contrarresten     dicha     satisfacción.     El propósito   fue   diagnosticar   el   estado actual de la satisfacción del usuario de la municipalidad  distrital  de  Jayanca.  Este estudio  fue  de  tipo  básica  y  un  diseño descriptivo    no    experimental    con    un enfoque  cuantitativo;  asimismo,  se  usó una  muestra  de  337  usuarios  empleando un    muestreo    probabilístico    aleatorio simple.   Obteniendo   un   resultado   que el  50%  de  usuarios  respondieron  nunca toman  medidas  correctivas  para  mejorar la  simplificación  administrativa,  el  29% manifestaron  que  casi  nunca,  el  10%  a veces,  el  7%  siempre  y  por  último  el  4% casi siempre. En la cual se concluye, que los usuarios tienen una percepción de que la  administración  nunca  toma  medidas correctivas para mejorar la simplificación administrativa. Por lo tanto, urge diseñar un modelo de simplificación administrativa para mejorar la calidad de atención.
Incidencia de la responsabilidad social corporativa en el desarrollo económico. Caso: Sector cooperativo financiero del segmento cuatro
Authors: Muyulema-Allaica Carina Alexandra , Muyulema-Allaica Juan Carlos , Usca-Veloz Roberto Bernardo , Rodríguez-Alzamora Ricardo Javier
Published: May 2022

La responsabilidad social corporativa (RSC) es una tendencia empresarial relativamente moderna, que ha sintetizado y normalizado pautas de conducta preexistentes en el entorno de los negocios, las cuales, están relacionadas al entorno económico, social y ambiental. El objetivo del estudio fue analizar la incidencia de la RSC en el desarrollo económico del sector cooperativo financiero del segmento cuatro de la provincia de Chimborazo - Ecuador. La estrategia metodológica recayó sobre un método cuantitativo, con la finalidad aplicada práctica e interpretación de los datos a través del alcance descriptivo-correlacional. La técnica de recolección de datos (lista de chequeo), se basó en el Modelo de Balance Social desarrollado por la Superintendencia de Economía Popular y Solidaria a partir del año 2013. La investigación permitió conocer datos relevantes sobre la aplicación de la RSC en el sector cooperativo. Se concluye que, las entidades financieras ejecutan acciones socialmente responsables y no informan adecuadamente.
Morosidad y su incidencia en la rentabilidad de una institución básica regular
Authors: Huamán Espinoza Carlos Henrry , Córdova Llacsahuache Alfredo , Romero-Carazas Rafael , Apaza Romero Iván
Published: May 2022

La morosidad en las empresas se debe menguar para no afectar la rentabilidad, uno de los sectores más afectados por este mal es el educativo. Por ello, la investigación buscó establecer de qué manera la morosidad incide en la rentabilidad de la I.E. Adventista Chiclayo, periodo 2016 – 2020. Así, se siguió una metodología mixta, descriptiva y de corte transversal, con una muestra de dos profesionales a los que se aplicó un cuestionario procesado por el sistema SPSS. Asimismo, uno de los alcances señalado fue que las dificultades financieras de la I.E. se originaron por el mal manejo que hacen los clientes de sus recursos. También se concluyó que la morosidad incide en la rentabilidad de la I.E. Adventista Chiclayo, donde la correlación Rho de Spearman es igual a 1,000, con lo cual se determina que la morosidad afecta la utilidad, calidad del servicio y las obligaciones financieras de la empresa.
Uso de plataforma Microsoft teams y satisfacción académica en el posgrado de la Universidad Nacional Federico Villarreal
Authors: Saavedra López Juan José , Garvich Ormeño Angie Marlene , Zorrilla Díaz José Eduardo
Published: May 2022

La pandemia ocasionó una serie de problemas y muchos desafíos para todos los sectores productivos del Perú, especialmente en el ámbito educativo, donde para garantizar la continuidad de la educación se migró a la virtualidad en muy poco tiempo. La presente investigación tuvo como propósito relacionar el uso de la plataforma TEAMS con la satisfacción académica del estudiante de postgrado de la Universidad Nacional Federico Villarreal. Fue una investigación descriptiva correlacional de diseño no experimental y de corte trasversal aplicado a una muestra de 110 estudiantes. Para la recolección de datos, se usaron 2 cuestionarios que cuentan con validez de constructo y confiabilidad Alfa de Cronbach del 0,852 y 0,866 respectivamente.  Los resultados señalaron que sí existe una correlación significativa entre ambas variables, lo que se ve reflejado en el Coeficiente de correlación de Spearman de 0.795. Se concluyó que el uso efectivo de la plataforma TEAMS garantiza la satisfacción académica del estudiante de posgrado.
Gestión de calidad en el servicio de transporte de carga pesada
Authors: Mera Guzmán Pamela Elizabeth , Mera Guzmán Vanessa Carolina , Toscano Morales Cecilia Catalina , Ruiz Robalino Oscar Eduardo
Published: May 2022

La gestión de calidad es un conjunto de normas o actividades para ofrecer un servicio o producto de calidad a los usuarios o consumidores, cumpliendo requisitos generados por los clientes que necesitan puntualidad, seguridad y confianza. La investigación tuvo como objetivo empresarial describir los procesos de la gestión de calidad del servicio de transporte de carga pesada en base al modelo Servqual con estándares internacionales para la prestación de servicio tangible a los clientes y usuarios, que son necesarios para generar fiabilidad, tangibilidad, seguridad desde el primer contacto comunicacional, logística de embarque, transporte y entrega con seguridad en los tiempos y plazos requeridos. El tipo de investigación fue la descriptiva, apoyada en la de Campo y Documental con un enfoque mixto porque utiliza datos cuantitativos y cualitativos. Como resultado de la investigación se debe generar procesos de mejora continúa en toda la cadena de gestión del transporte de carga pesada.
PENINGKATAN PENGETAHUAN ANAK SEKOLAH DASAR TENTANG PHBS MELALUI MEDIA ULAR TANGGA YANG DIMODIFIKASI
Authors: Fithri Asep , Karjatin Atin , Lestari Febri Sri
Published: May 2022

Perilaku Hidup Bersih dan Sehat (PHBS) bisa menjadi pondasi dari perilaku sehat bagi siswa, guru dan masyarakat dilingkungan sekolah. Sehingga upaya memberdayakan siswa, guru, dan masyarakat lingkungan sekolah agar berperan aktif mewujudkan sekolah sehat melalui PHBS menjadi salah satu strategi yang tepat untuk meningkatkan derajat kesehatan masyarakat.

Penggunaan berbagai metode dan media promosi kesehatan yang beragam diyakini dapat membantu meningkatkan pengetahuan siswa akan PHBS di sekolah, salah satunya adalah permainan ular tangga yang dimodifikasi dengan penambahan kartu PHBS. Media promosi kesehatan ini diharapkan memiliki pengaruh yang signifikan dalam meningkatkan perilaku hidup bersih dan sehat melalui pengetahuan, sikap dan tindakan. Tujuan penelitian ini adalah untuk mengetahui perbedaan skor nilai pengetahuan, sikap, tindakan dan perilaku sebelum dan sesudah siswa bermain game ular tangga yang dimodifikasi di SD Negeri Cibeureum I Kabupaten Bandung. Penelitian ini menggunakan desain quasy eksperiment dengan desain one group pretest-posttest design pada 21 orang siswa SD Negeri Cibeureum I Kabupaten Bandung. Penelitian ini menggunakan alat ukur kuesioner dan lembar observasi. Analisis data menggunakan univariat dan bivariat dengan uji paired sample t-test pada α 0.05.

Hasil analisis data menunjukkan Penggunaan media promosi kesehatan “Ular Tangga Yang Dimodifikasi” secara signifikans dapat meningkatkan Pengetahuan Dan Perilaku Hidup Bersih Dan Sehat Di Sekolah Dasar Negeri Cibeureum I Kabupaten Bandung.
Glomerular filtration rate in centenarians with coronary artery disease
Authors: Тополянская С.В. , Елисеева Т.А. , Санина А.И. , Вакуленко О.Н. , Дворецкий Л.И.
Published: May 2022

Цель исследования - сравнение методов расчета по формулам CKD-EPI, MDRD, BIS1 и Кокрофта-Голта для расчета СКФ, а также анализ различных взаимосвязей СКФ и клинических и лабораторных параметров у долгожителей с ИБС. Данная работа - одномоментное (поперечное) исследование, в которое были включены 270 пациентов 90-106 лет, госпитализированных с диагнозом ИБС. Средняя СКФ по формуле CKD-EPI составила 51,4±14,2 мл/мин, MDRD - 50,9±13,4, BIS1 - 38,4±7,7, Кокрофта-Голта - 40,6±12,6. Лишь у 75 (27,8 %) пациентов СКФ была ≥60 мл/мин. Чаще всего регистрировали IIIА стадию ХБП, тогда как V стадию не наблюдали ни у одного больного. Результаты определения стадии ХБП, рассчитанные с использованием формул MDRD и CKD-EPI, были аналогичными. Однако при использовании формулы BIS1, СКФ >60 мл/мин не зарегистрировали ни у одного пациента, а подавляющее большинство больных (64,1 %) имели ХБП IIIБ стадии. При высоком уровне креатинина не было значительных различий между показателями СКФ, рассчитанными с помощью разных формул, в то время как при низких и средних значениях креатинина наблюдали существенные различия в СКФ, оцененной с помощью формул CKD-EPI и MDRD, с одной стороны, и BIS1 и Кокрофта-Голта - с другой. Максимальные различия достигали 21 мл/мин.

The study objective was to compare the CKD-EPI, MDRD, BIS1, and Cockroft-Gault equations for calculating GFR, and analyze the various relationships between the glomerular filtration rate and clinical and laboratory parameters in long-living patients with coronary artery disease (CAD). A cross-sectional study of 270 patients from 90 to 106 years old, hospitalized with CAD diagnosis, was performed. The mean estimated GFR according to CKD-EPI was 51,4±14,2 ml/min, MDRD - 50,9±13,4, BIS1 - 38,4±7,7, Cockroft-Gault - 40,6±12,6 ml/min. Only 75 patients (27,8 %) had CKD-EPI eGFR greater than or equal to 60 ml/min. The most common stage of chronic kidney disease was stage 3A, while stage CKD 5 did not occur at all. CKD staging results calculated using the MDRD and CKD-EPI equations were similar. However, when using the BIS1 equation, eGFR of more than 60 ml/min was not observed in any patient, and the vast majority of patients (64,1 %) had stage 3B CKD. At high creatinine levels, there were no considerable differences between eGFR according to different equations, while at low and medium creatinine values, there were significant differences in eGFR, assessed using the CKD-EPI and MDRD equations on the one hand and BIS1 and Cockroft-Gault on the other. The maximum differences reached 21 ml/min.
Socio-cognitive correlates of life satisfaction of students of the National University aged 55-80 years
Authors: Долгова В.И. , Рокицкая Ю.А.
Published: May 2022

Достижение удовлетворенности жизнью в условиях сложной эпидемиологической ситуации, детерминирующей хронический стресс, затянувшийся режим социально-экономических ограничений и самоизоляции, повышенную смертность, представляется актуальной и, вместе с тем, трудно разрешимой задачей. Поэтому понимание социально-когнитивных коррелятов жизненной удовлетворенности после 55 лет позволяет моделировать её ментальные конструкции, имеющие стресс-протекторное свойство, с последующей возможностью их психологической коррекции. Цель исследования - теоретически обосновать, выявить и обсудить результаты анализа корреляции социально-когнитивных особенностей и жизненной удовлетворённости после 55 лет. Гипотеза исследования базируется на предположении о взаимосвязи исследуемых показателей. Теоретический анализ феноменологии удовлетворённости жизнью выявил социально-когнитивную природу и эмоциональную, отражательно-оценочную индикацию её возникновения, функционирования и динамики. Применяли следующие психодиагностические методики: опросник «Ваше самочувствие» (авторы - О.С. Копина, Е.А. Суслова, Е.В. Заикин), методику диагностики наличия и выраженности иррациональных установок (А. Эллис), методику диагностики социально-психологических особенностей (Т. Лири). Выборочную совокупность составили 80 человек 55-80 лет. Корреляционный анализ выявил взаимообусловленность показателей жизненной удовлетворённости и социально-когнитивных характеристик личности в пожилом возрасте.

Achieving life satisfaction in a complex epidemiological situation that determines chronic stress, a prolonged regime of socio-economic restrictions and self-isolation, increased mortality, seems to be an urgent and at the same time difficult to solve task. Therefore, understanding the socio-cognitive correlates of life satisfaction after 55 years allows us to model its mental constructions that have a stress-protective property, with the subsequent possibility of their psychological correction. The purpose of the study is to theoretically substantiate, identify and discuss the results of the correlation analysis of the relationship between socio-cognitive characteristics and life satisfaction after 55 years. The hypothesis of the study is based on the assumption of the relationship between the studied indicators. Theoretical analysis of the phenomenology of life satisfaction (life satisfaction) revealed the socio-cognitive nature and emotional, reflective and evaluative indication of its occurrence, functioning and dynamics. Psychodiagnostic methods were used: the questionnaire «Your well-being» (O.S. Kopina, E.A. Suslova, E.V. Zaikin), methods for diagnosing the presence and severity of irrational attitudes (A. Ellis), methods for diagnosing socio-psychological characteristics (T. Leary). The sample consisted of people aged 56-80 years in the number of 80 people. Correlation analysis revealed the conditionality of indicators of life satisfaction and socio-cognitive characteristics of a person in old age.
КЫРГЫЗ АДАБИЯТЫН ЭТНОПЕДАГОГИКАЛЫК НЕГИЗДЕ ОРТО МЕКТЕПТЕ ОКУТУУНУН ЭГЕМЕНДҮҮЛҮКТӨН КИЙИНКИ ОКУУ СТАНДАРТЫНДА ОРУН АЛЫШЫ ЖАНА ПРОБЛЕМАЛАРЫ
Authors: Кенжешев К.
Published: May 2022

Макалада орто мектептерде кыргыз адабиятын этнопедагогикалык негизде окутуунун
эгемендүүлүктөн кийинки окуу стандартында ээлеген ордукаралат. Өлкөнүн эгемендүүлүгүнөн кийинки орто мектепте окуу стандарты жаңыланып, ага байланыштуу проблемалар пайда болгону, анын бири этнопедагогика экендиги улуттук жалпы билим жана тарбия берүүнүн соңку стандартына негизделип түшүндүрүлөт. Өзгөчө өлкөдө жаш муундарды улуттук иденттүүлүктө тарбиялоо милдеттери компетенцияларга байланыштырылып чечмеленет. Ал көркөм чыгармалардын идеялык мазмунунда терең орун алып, баланын өсүп жетилүү үчүн кандай таасир берүүчү этнопедагогиканын мүмкүнчүлүгү окуу стандартында аныкталган компетенцияларга тиешелүү маселелердин чегинде мисалдар менен түшүндүрүлөт. Проблема акыркы мезгилдерде окуу процессине кирген парадигмалар менен байланыштырылып талдоого алынат да, анын практикалык иштердин чегинде түзгөн ыңгайсыз
жагдайлары эмне себептен болгонун аныктоого аракеттер жасалат.
В статье исследуется место преподавания кыргызской литературы на этнопедагогической основе в средней школе в образовательном стандарте в годы независимости. За годы независимости образовательный стандарт страны обновился, и, в связи с этим, возникли проблемы обучения и
воспитания детей на этнопедагогической основе. В частности, воспитание подростков в национальный идентичности определяется компетенциями. Определяется место этнопедагогики в идейном содержании художественного произведения, связь с компетенциями в образовательном стандарте и роль в воспитании и развитии ребёнка. Анализируется взаимосвязь этнопедагогики и парадигмы учебного процесса в последние годы и причины возникновения проблемы в рамках практической работы. Учитель начальной школы должен обладать необходимыми компетенциями, поэтому он обязан иметь специальную этнопедагогическую подготовку.
The article examines the place of teaching Kyrgyz literature on an ethno-pedagogical basis in secondary schools in the educational standard during the years of independence. During the years of independence the educational standard of the country has been updated, and in this regard, the problems of teaching and educating children on an ethno-pedagogical basis have arisen. In particular, the education of adolescents in the national identity is defined by competencies. The place of ethnopedagogy in the ideological content of the work of fiction, the relationship with the competencies in the educational standard and the role in the upbringing and development of the child are defined.