bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessment of Variability and Association on Bruchine Resistance Traits (Callosobruchus maculatus F.) among Segregating Populations of Blackgram [Vigna mungo (L.) Hepper]
Authors: Ragul S. , Manivannan N. , Iyanar K. , Ganapathy N. , Karthikeyan G.
Published: May 2022

Background: Bruchine is one of the notorious pests that renders both the quantity and quality of pulses stored produce especially blackgram. Hence the present study was carried out to ascertain the essential selection indices among the bruchine resistance traits involved. Methods: A laboratory experiment was conducted to estimate the variability parameters for traits related to bruchine infestation in various crosses of blackgram viz., MDU1 × TU68, VBN6 × TU68 and VBN8 × TU68 at National Pulses Research Centre, Vamban. Observations were recorded for eight bruchine resistance traits on each single plants from three crosses. Result: The results indicated that all traits viz., total number of adult emergence, developmental time, mean developmental period, index of susceptibility, seed damage (%) and seed weight loss (%) recorded high PCV and GCV in all crosses except developmental time which had moderate to low variation. All traits also recorded high heritability and genetic advance as per cent of mean in all crosses except developmental time. Developmental time had moderate to high heritability and genetic advance over the crosses. Considering skewness and kurtosis, the cross MDU 1 × TU 68 had a wide variation for total number of adult emergence and seed damage. Hence the cross MDU 1 × TU 68 could be selected for the selection of bruchid resistant individuals. The association studies revealed that traits viz., developmental time, total number of adult emergence, index of susceptibility and seed damage were reliable selection indices for the seed weight loss.
Взяти інтерв’ю у „легенди”: Ліна Костенко та колективна пам’ять шістдесятництва
Authors: Bellezza Simone Attilio
Published: May 2022

A feeling of discomfort and disappointment towards the collective memory of the shistdesiatnytstvo in Ukraine emerged during the interview with Lina Kostenko, as well as with other shistdesiatnyky. The public discourse, including many scholarly studies on the topic, usually ignores the ethic and “affective” components which were so important to the members of this movement, whose behavior and universe of values radically differed from the Stalinist Soviet respectability. The function of the shistdesiatnytstvo as the detonator of a positive nationalism is thus neglected. Some important stages in the formation of Lina Kostenko’s personality are then analyzed: the family upbringing based on the love for Ukrainian and worldwide culture, the traumas of childhood during World War II, the importance of building friendly bonds with other shistdesiatnyky, especially with Vasyl’ Symonenko.
LEADERSHIP INITIATIVE TO ENRICH THE HIV/AIDS EDUCATION FOR SENIOR HIGH SCHOOLS
Authors:   RN, MAN, EdD., Assistant Professor III, Department of Arts and Sciences, City College of Calamba, Calamba City, Philippines, Quintana Marc Lester F. , Martinez Ma. Cecilia O. ,   RM, RN, MAN, EdD., Associate Professor 2, College of Nursing, Pamantasan ng Lungsod ng Maynila, Manila, Philippines
Published: May 2022

This research determined the degree of leadership initiative of the 376 senior high school students from Laguna Philippines Local Colleges and Universities (LCUs) to enrich their HIV/AIDS education. Results showed that the students have high levels of knowledge and awareness on HIV/AIDS and its effects on physical, psychological, social, and spiritual aspects. They have a high status of opportunities in terms of their current senior high school curriculum vis-à-vis HIV/AIDS education; which means that the students have a high degree of becoming leaders on their own accord; especially if the local colleges and universities coordinate and collaborate with each other. Health Education on HIV/AIDS was a joint effort of these collaborations that educated the senior high school students accurately and completely about HIV/AIDS. Results also showed that the students have a high status of challenges and weaknesses, and low status of strengths for their current senior high school curriculum vis-à-vis HIV/AIDS education. Thus, it was recommended that they must become more conscious on what level do they understand/know about HIV /AIDS; be transformed in terms of their attributes in becoming leaders advocating about HIV/AIDS for every young person in every community.
PSYCHOLOGICAL WELL-BEING AND SMARTPHONE USE AMONG COLLEGE STUDENTS
Authors:   The Bishop Strachan School, Toronto, Canada, Zheng Selina
Published: May 2022

People’s overdependence on smartphones has led them to an abundance of psychological well-being issues. Various literature has examined the association between smartphone use, addictive behaviours, and mental well-being. To develop a deeper understanding of the correlation among these factors, the current study aims to find the psychological impact on smartphone use. Smartphone use and psychological well-being, specifically on how adolescents’ media use has led them to mental health issues such as addiction, depression, anxiety, sleep problems, and the fear of missing out (FoMO). The results supported hypotheses 1, 2, and 3, smartphone addiction correlates with anxiety, depression, and FoMO; however, the results of the study do not support hypothesis 4, in which there is no correlation between smartphone addiction and sleep issues. In conclusion, smartphone overuse and addiction may subsequently affect an adolescent’s mental well-being.
NOTE-TAKING DRILLING TO IMPROVE ACADEMIC LISTENING SKILLS IN THIRD SEMESTER STUDENTS, UNIVERSITAS MUHAMMADIYAH SURAKARTA
Authors:   S.Pd., M.A., Department of English Education, Teacher Training Faculty, Universitas Muhammadiyah Surakarta, Surakarta, Central Java, Indonesia, Mandiri Angger Septo ,   Department of English Education, Teacher Training Faculty, Universitas Muhammadiyah Surakarta, Surakarta, Central Java, Indonesia, Pratiwi Ulya Septiana ,   S.Pd., Department of English Education, Teacher Training Faculty, Universitas Muhammadiyah Surakarta, Surakarta, Central Java, Indonesia.
Published: May 2022

This study aims to reveal the role of note-taking in improving listening skills and exposing learning resources besides TED.COM. The skill of note-taking in academic activities is subject to the incompetency of note-taking in standard form. This research was a classroom action research approach for third-semester students at the Universitas Muhammadiyah Surakarta that focused on TED.COM’s contribution to students’ skills. The results of the initial research found obstacles, first, students were getting to know note-taking and TED.COM for the first time. Second, the high speed of native speakers impacts lost vocabulary understanding. Third, the tone, accent, and intonation are also separate challenges. The results of the cycles showed first, there was a positive change since the students got an extra note-taking theory and variations of audio listening. Second, students have varied learning resources, so it is recommended for educators to also understand student learning resources. In conclusion, TED.COM contributed to the academic listening improvement and in the future, the Podcast program can be explored for note-taking drilling besides TED.COM.
Current trends in the formation of the digital infrastructure of Russian education
Authors:   Moscow State University of Humanities and Economics, Allahverdiyeva Leila M. ,   Gzhel State University, Gasparishvili Alexander T. ,   Lomonosov Moscow State University,   FCTAS RAS,   RUDN University
Published: May 2022

The article analyzes the problems of forming a digital infrastructure for education in the process of the widespread and active use of new digital technologies in educational activities. The relationship of their use with traditional teaching methods and with educational processes is considered, attempts are made to find possible ways to combine new digital learning formats with traditional.
Socio-technological aspects of assessment and management of educational risks at University
Authors:   St. Petersburg State Chemical and Pharmaceutical University, Safronova Zhanna S. , Brazevich Dmitrii S. ,   St. Petersburg State University of Civil Aviation, Major Michail N.
Published: May 2022

The authors analyze social technological aspects of managing educational risks at a university, which help management make decisions that positively affect the level of educational services and competitiveness. This article highlights systemic nature and features of risk management at a modern university. The authors show the variety of educational risks and classify them by type. The definition of educational risks should be based, first of all, on the criteria for the quality of education of a university, based on external and internal goals determined by the state, consumers of services and a university. Management of external and internal risks determines an image and rating of a university, thereby ensuring its own competitiveness in the market of educational services. According to the authors, risk management planning should begin not only with identification of possible risks, but also with identification of the entire complex of risk factors. Management should take into account internal risks generated by a university, which affect external risks that either level or exacerbate them. They provide a simplified diagram of a model for assessing and managing educational risks at a university.
Project of the technological community of primary professionalization
Authors:   Municipal educational budget school “Suzanovsk medium educational school”, Pachar Victor V. , Pachar Elena I. , Pachar Vyacheslav A.
Published: May 2022

The article is devoted to the creation of a project of the technological community for the subjects of the educational process. It is assumed that the main ideas of the community will be implemented on the digital platform “Faculty”. The authors of the article outlined the goal of creating a community, the benefits and opportunities from its use by interested parties. In the course of the work, possible risks of launching and functioning of the community were identified, a roadmap (milestones) of the project was prepared, and indicators for evaluating the effectiveness of using the technology community were identified.
Professional competences of a doctor: Ethical and Deontological aspects
Authors:   Moscow State University of Medicine and Dentistry n.a. A.I. Evdokimov, Zorin Konstantin V.
Published: May 2022

The article formulates a number of ethical and deontological aspects of the training and work of a doctor. It has been revealed that there is a need for medical students and practicing doctors to form some important professional competencies, based on spiritual and moral culture, personal maturity, conscientiousness, mercy, as well as the ability to avoid and overcome conflict situations using the basic principles of biomedical ethics. Group discussion and solution of controversial ethical and deontological cases using the method of analysis of the presented situation prepares a medical student for communication, treatment, diagnostic and educational and preventive work with a patient who is faced with a difficult choice and must make an important decision.
Practical training: The formation of professional competencies of pediatric graduates
Authors:   Ural State Medical University Ministry of Healthcare of Russia, Stennikova Olga V.
Published: May 2022

The modern strategy for the development of medical and pharmaceutical education in the Russian Federation has a practice-oriented approach. In the implementation of this approach when studying at a medical university, it is important not only to form the competencies of future medical doctors among students, but also to form the interest of employers of medical organizations in the training of future specialists. The aim of the study was to analyze the opinions of graduate students of the pediatric faculty and employers of medical and preventive institutions regarding the importance of practical training in the education of highly qualified specialists and solving staffing issues. The research was carried out by a questionnaire method. The findings underscore the importance of practical training, both in the opinion of future doctors and employers. Practical training enables the student to implement theoretical knowledge in practice, creates the clinical thinking of a pediatrician, promotes a smoother transition from student to practicing specialist with the ability to apply theoretical knowledge in his practice. The analysis of employers' opinions revealed difficulties among students in resolving conflict situations and performing emergency aid algorithms. The importance of the target basis of training, which creates mutually beneficial conditions for a young specialist and a medical organization, is noted. The step-by-step acquaintance realized during the target learning framework contributes to solve the problem of staff shortages in the Healthcare of the region.
Problems of ethnopsychology in the context of the worldview of Antiquity
Authors:   Russian Academy of Natural Sciences, Lazarev Maxim A.
Published: May 2022

Based on the analysis and reconstruction of ancient methodology, the article examines approaches to ethno- and historical psychology. These relatively new areas of psychological and philosophical knowledge are developed from the foundations of the ancient worldview, which is basic for the entire modern European civilization. The teaching of Hippocrates on temperaments, presented through the prism of natural philosophy and elemental dialectics, is considered as the fundamental ancient concept.
From the experience of teaching the Russian language at Xi’an Petroleum University
Authors:   Xi’an Shiyou University, Hudie Luo
Published: May 2022

Based on the analysis of publications it has been revealed that one of the priority directions of state policy in the leading countries of the world is internationalization of education as a set of purposeful measures of integration of educational content in order to form cross-cultural competences. The process of internationalization of education in China is characterized by an increase in research and educational programs, expansion of faculty mobility, improvement of the legal framework for international mobility. The implementation of the international Chinese initiative “One Belt, One Road” has put forward new requirements for the training of highly qualified specialists in the Russian language. Chairs of the Russian language in Chinese universities are constantly reforming and updating training models to meet the requirements of the new situation. In this article we analyze the practice of the joint Chinese-Russian educational program for the training of Russian-speaking bachelors. The measures to improve the model of joint training of Russian-speaking specialists in Xi’an Oil University are named: a wide implementation of digital technologies, pre-training curriculum, international teaching teams, administration and support of the educational process, adaptation of professional competencies in Russian language for technical, engineering and military professions; creation of a translation methodology of academic grades; support for students to address academic and social issues during foreign.
Hermeneutika dalam Tafsir al-Mishbah: Studi Penafsiran Surat Al-Ahzab Ayat 59
Authors: Riza Muhammad Himmatur , Hidayah Vika Rachmania
Published: May 2022

Muhammad Quraish Shihab adalah salah seorang ulama dan cendikiawan muslim Indonesia yang menekuni bidang tafsir al-Qur’an. Karya-karyanya telah memberikan kontribusi pada perkembangan keilmuan di Indonesia terkhusus pada bidang al-qur’an. Dari sekian banyak karyanya, Tafsir Al-Misbah: Pesan, Kesan dan Keserasian al-Qur’an merupakan Mahakarya yang menjadikan namanya membumbung sebagai salah satu muffasir Indonesia, yang mampu menulis tafsir al-Qur’an 30 Juz dari Volume 1 sampai 15. Penafsiran dalam surat Al-Ahzab ayat 59 Quraish Shihab menafsirkan dengan mengungkap asbab an-nuzul ayat, bahwa sebelum ayat ini turun cara berpakaian wanita baik Budak atau Wanita merdeka adalah sama, oleh karena itu laki-laki hidung belang sering mengganggu dengan menduga semua wanita yang demikian itu adalah budak. Untuk menjaga kehormatan wanita merdeka maka ayat tersebut turun. Menurut Quraish Shihab, disamping terjadi perbedan antar para ulama, surat Al-Ahzab ayat 59 tidaklah memerintah wanita untuk memakai jilbab, dengan alasan ayat di atas turun sebagaimana mereka sudah memakai jilbab, hanya saja cara memakainya belum dikehedaki sebagaimana ayat tersebut.
The electronic catalog creation in the library of the Znamensky Cathedral of Kemerovo diocese
Authors: Sakova O. Ya. , Paderina A. I.
Published: May 2022

The goal of the article is to present the experience of creating an electronic catalog of the library of the Znamensky Cathedral of Kemerovo diocese. The article examines the history of the library foundation, its role in the educational activities of Kemerovo diocese. The characteristic of documents of the library collections as objects of metadata forming when creating the electronic catalog is given, the availability of both religious and secular literature in different languages including reprint publications and electronic resources is emphasized. The technology for creating the electronic catalog using the “Authoritative Files” database, developed by the catalogers of the State Scientific Library of Kuzbass named after V. D. Fedorov, is described in detail. Regulatory documents including national standards are listed as well as the software in the form of the automated library and information system “OPAC-Global” and linguistic tools used in cataloging are presented. The classification table brief characteristic and its peculiarities used in the systematization of documents in the library under analysis is given. The experience of working together the Znamensky Cathedral, the State Scientific Library of Kuzbass named after V. D. Fedorov and Kemerovo State Institute of Culture in the project “The Electronic Catalog Creation in the library of the Znamensky Cathedral” is summarized. Participation of KemSIC Faculty of Information and Library Technologies students in this project within their work practice for to perfect their cataloging skills and abilities is emphasized. The quantitative results of the creation of bibliographic records in the electronic catalog for the period of 2021 are presented. In the conclusion, the outlook for the electronic catalog being created in the activities of the Znamensky Cathedral library is denoted: optimization of the information search, the opportunity to participate in the machine-readable cataloging projects, the creation of the quality system of library and information services for readers.
Living With MYALGIC ENCEPHALOMYELITIS: An Invisible Disability
Authors:   University of Dundee, Jindal-Snape Divya , Murray Chris ,   University of Dundee, Camilleri Rebecca , Debono Ruth , Gauci Maria , Herd Damon , Affleck Steven , Elise Rebecca , Santiago Tasha Leah , Mintoff Marilyn
Published: May 2022

Contents: Living with Myalgic Encephalomyelitis (ME) and Post-exertional Malaise - page 3 Story: Rebecca Camilleri; Script: Divya Jindal-Snape; Art: Steven Affleck Living with ME: A New Reality - page 4 Story: Rebecca Camilleri; Script: Divya Jindal-Snape; Art: Steven Affleck Working and Living with Myalgic Encephalomyelitis - page 7 Story: Maria Gauci; Script: Divya Jindal-Snape; Art: Rebecca Elysium Grocery Shopping: Myalgic Encephalomyelitis and Post-exertional Malaise - page 8 Story: Rebecca Camilleri; Script: Divya Jindal-Snape; Art: Tasha Leah Santiago Mysterious Pain - Invisible Disability - page 9 Author: Ruth DeBono; Art: Tasha Leah Santiago
Ambient light energy intensity as a trigger for the dawn chorus: Patterns in five common eastern Australian bird species
Authors: Wilkinson Kevin , Palmer Grant ,   Future Regions Research Centre, Federation University Australia, University Drive, Mount Helen VIC 3350, Australia.
Published: May 2022

The timing of the morning twilight commencement of bird song has been linked to mating, stores of food energy or territorial declarations, and is known to follow a structured, spaced order to avoid signal interference. The timing of vocalisations has been widely studied and varies with ambient and broader environmental variables, including moonlight and cloud cover. In this study, the commencement of morning song for five common species (Masked Lapwing Vanellus miles, Australian King- Parrot Alisterus scapularis, Lewin’s Honeyeater Meliphaga lewinii, Eastern Yellow Robin Eopsaltria australis and Australian Magpie Gymnorhina tibicen) and the relationship with light energy intensity were investigated on the New South Wales Midnorth Coast, eastern Australia. It was determined that each species responded to a specific threshold light intensity as a trigger to commence singing. The timing of song commencement aligned with shifts in the required threshold light level, which was influenced by environmental variables such as moonlight (earlier) and cloudiness (later for some species). It is proposed that the structured routine of the first song of some birds, during nautical twilight, is a result of evolutionary variations in their eye structure, resulting in varying perceptions of the first morning light from the sky, leading to species commencing singing at different times.
Clinical Characteristics, Genetic Findings and Arrhythmic Outcomes of Patients with Catecholaminergic Polymorphic Ventricular Tachycardia from China
Authors: Leung Justin , Lee Sharen , Zhou Jiandong , Jeevaratnam Kamalan , Lakhani Ishan , Radford Danny , Coakley-Youngs Emma , Pay Levent , Cinier Goksel , Altinsoy Meltem , Behnoush Amir , Mahmoudi Elham , Matsuik Pawel , Bazoukis George , Garcia-Zamora Sebastian , Zeng Shaoying , Chen Ziliang , Xia Yunlong , Liu Tong , Tse Gary
Published: May 2022

Introduction: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare cardiac ion channelopathy. This study examined the clinical characteristics, genetic basis, and arrhythmic outcomes of CPVT patients from China.
Methods: PubMed and EMBASE were systematically searched for case reports or series reporting on CPVT patients from China until February 19th, 2022 using the keyword “Catecholaminergic Polymorphic Ventricular Tachycardia” OR “CPVT”, with the location limited to “China” OR “Hong Kong” or “Macau” in EMBASE, with no language or publication type restriction. Clinical characteristics, genetic findings, and primary outcome of spontaneous ventricular tachycardia/ventricular fibrillation (VT/VF) were analyzed.
Results: A systematic search of the PubMed and Embase databases yielded 1049 and 47 articles, respectively. After the exclusion of overlapping cohorts, a total of 58 unique cases from 15 studies (median presentation age: 8 [5.0-11.8] years old) were included. All patients except for one presented at or before 19 years of age. 56 patients (96.6%) were initially symptomatic. Premature ventricular complexes (PVCs) were present in 44 of 51 patients (86.3%) and VT in 52 of 58 patients (89.7%). Genetic tests were performed on 54 patients (93.1%) with a yield of 87%. RyR2, CASQ2, TERCL, and SCN10A mutations were found in 35 (71.4%), 12 (24.5%), one (0.02%) patient, and one patient (0.02%) respectively. 54 patients were treated with beta-blockers, eight received flecainide, five received amiodarone, two received verapamil and one received propafenone. Sympathectomy (n=10) and implantable-cardioverter defibrillator implantation (n=8) were performed. On follow-up, 13 patients developed VT/VF.
Conclusion: This is the first systematic review of CPVT patients from China. Most patients had symptoms on initial presentation, with syncope as the presenting complaint. RyR2 mutation accounts for more than half of the CPVT cases, followed by CASQ2, TERCL and SCN10A mutations.
3,5-T2 - An Endogenous Thyroid Hormone Metabolite As Promising Lead Substance in Anti-Steatotic Drug Development?
Authors: Sane Rajas , Wirth Eva K. , Köhrle Josef
Published: May 2022

Thyroid hormones, their metabolites and synthetic analogues are potential anti-steatotic drug candidates considering that subclinical and manifest hypothyroidism is associated with hepatic lipid accumulation, non-alcoholic fatty liver disease, and its pandemic sequelae. Thyromimetically active compounds stimulate hepatic lipogenesis, fatty acid beta-oxidation, cholesterol metabolism and metabolic pathways of glucose homeostasis. Many of these effects are mediated by T3 receptor β1-dependent modulation of transcription. However, rapid non-canonical mitochondrial effects have also been reported, especially for the metabolite 3,5-diiodothyronine (3,5-T2), which does not elicit the full spectrum of “thyromimetic” actions inherent to T3. Most preclinical studies in rodent models of obesity and first human clinical trials are promising with respect to the antisteatotic hepatic effects, but potent agents exhibit unwanted thyromimetic effects on the heart and/or suppress feedback regulation of the hypothalamus-pituitary-thyroid-periphery axis and the fine-tuned thyroid hormone system. This review focusses on 3,5-T2 effects on hepatic lipid and glucose metabolism and (non-)canonical mechanisms of action including its mitochondrial targets. Various high fat diet animal models with distinct thyroid hormone status indicate species- and dose-dependent efficiency of 3,5-T2 and its synthetic analogue TRC150094. No convincing evidence has been presented for their clinical use in prevention or treatment of obesity and related metabolic conditions.
Neonatal Resuscitation in Primary Health Care Facilities
Authors: Saptaning Astyari Gusti Ayu Putu Ika Bella , Zagoto Rabel Relianta , Ngahu Oby Mesakh
Published: May 2022

Background : Neonatal resuscitation is an action that must be done in the first minute when a newborn with severe asphyxia is born.

Case Illustration : The case was infant  whom born spontaneously from 41 years old woman, G7P6A0 in primary health care facilities at Kokoda Utara District, with a condition did not cry or breathe, the skin color was bluish, there was no muscle tone, APGAR score was 0. Infant did not show any response, so we gave positive pressure ventilation using a bagging mask and chest compression with compression techniques by using both thumbs and other fingers around the chest supporting from the back, with a ratio of 3 compressions per 1 breath. After 60 minutes of resuscitation, the baby can cry loudly and the APGAR score is 10, heart rate was 140 beats per minute, breathing is 35 times per minute, SpO2 98%, blood glucose is 46 mg/Dl, body weight 2300 grams, body length 40 cm, head circumference 33 cm, chest circumference 32 cm, which indicates that the baby is no longer in asphyxia.

Conclusion : Rapid initial assessment of the newborn and appropriate implementation of neonatal resuscitation determines success and reduces mortality.
Source Analysis and Countermeasure Research of Sand Production after Hydraulic Fracturing in Tight Sandstone Gas Reservoir
Authors: Peng Huan , Yang Jian , Peng Junliang , Han Huifen , Gou Xinghao , Jia Yucheng
Published: May 2022

Sand production is the most common problem after hydraulic fracturing treatment. This problem is particular prominent in sandstone reservoirs. For Jinqiu gas reservoir of Sichuan Basin in China, the average sand production after fracturing is 103 tons, and the sand production rate is 2.36% through statistics of 12 wells. The sand production will seriously damage the downhole equipment as well as ground facilities. In this study, based on the analysis of sand production source, it is clear that the sand production mainly is 70/140 mesh sand flowback after hydraulic fracturing treatment. In order to control this proppant flowback, average fibers length of about 3 mm, 6 mm, 9 mm, and 12 mm are selected for proppant flowback control experimental study. A series of laboratory evaluations are designed to quantify the effectiveness of fibers on proppant flowback control, so as to explore the mechanisms behind for optimizing their properties for a chosen reservoir. The key fiber properties include dispersion performance, microstructure, the influence on proppant transport in fracture, fracture conductivity, and critical flowrate. The dispersion of fibers with different lengths and concentrations in slickwater is good, and the fibers can form a net-like structure that reinforces the pack, and for 70/140 mesh sand and 40/70 mesh resin-coated sand, with the increase of fiber length and concentration, the sand transport distance and critical flowrate increase, but fracture conductivity decreases. The field test is carried out through the fiber type and dosage optimized by indoor experiment. A systematic indoor evaluation and field test shows that fiber plays a significant role in proppant flowback control. The findings of this study can help for a better understanding of the source analysis and countermeasure research of sand production after hydraulic fracturing in tight sandstone gas reservoir.
Integrated Enhanced Cognitive Behavioural (I-CBTE) therapy significantly improves effectiveness of inpatient treatment of anorexia nervosa in real life settings
Authors: Ibrahim Ali , Ryan Sharon , Viljoen David , Tutisani Ellen , Gardner Lucy , Collins Lorna , Ayton Agnes
Published: May 2022

BackgroundInpatient treatment of anorexia nervosa can be lifesaving but is associated with high rates of relapse and poor outcomes. To address this, the Oxford service has adapted the enhanced cognitive behavioural treatment (CBTE) model, first developed in Italy, to a UK national health service (NHS) setting. In this study, we compared outcomes between treatment as usual (TAU), integrated CBTE (I-CBTE), with alternative treatment models in routine UK clinical practice.MethodsThis is a longitudinal cohort study, using routinely collected data between 2017–2020 involving all adults with anorexia nervosa admitted to specialist units from a large geographical area in England covering a total population of 3.5 million. We compared TAU with 1) I-CBTE (13 weeks inpatient CBTE, restoration to a healthy weight, combined with 7 weeks day treatment followed by 20 weeks followed by outpatient CBTE; 2) standalone inpatient CBTE (due to insufficient resources since the pandemic; and 3) 6–8 weeks admission with partial weight restoration as crisis management. Primary outcome measures (min. 1 year after discharge from hospital) were defined as: 1. good outcome: BMI>19.5 and no abnormal eating or compensatory behaviours; 2. poor outcome: BMI<19.5 and/or ongoing eating disorder behaviours; 3. readmission; or 4. deceased. Secondary outcomes were BMI on discharge, and length of stay. Results 212 patients were admitted to 15 specialist units in the UK depending on bed availability. The mean age was 28.9 (18-60) years, mean admission BMI was 14.1 (10-18.3), 80% were voluntary. At minimum 1-year follow up after discharge, 70% of patients receiving I-CBTE and 29% standalone inpatient CBTE maintained good outcomes, in contrast with <5% TAU and crisis management admission. Readmission rates of I-CBTE were 14.3% vs ~50% (χ2<0.0001) in the other groups. The main predictors of good long-term outcome were reaching healthy BMI by discharge, I-CBTE and voluntary status. Age, psychiatric comorbidity and length of stay did not predict outcomes. BMI on discharge and length of stay were significantly better in the CBTE groups than in TAU.ConclusionsOur main finding is that in a real-life setting, I-CBTE has superior short- and long-term outcomes as compared with alternative inpatient treatment models. Dissemination of I-CBTE across the care pathway has the potential to transform outcomes of inpatient treatment for this high-risk patient population and reduce personal and societal costs.
Analysis of the influence of rainfall infiltration on the stability of fractured rock slopes
Authors: Tan yinlong , xu wanzhong , Cao jiaju
Published: May 2022

At present, the research on the influence of rainfall infiltration on slope stability is mainly focused on soil slopes, while the research on fractured rock slope is relatively less. Under the condition of continuous rainfall, the coupling of seepage field and stress field generated by fractured rock slope is very likely to lead to slope instability damage. Based on the research of the slope engineering of a section of Haidong New Town, Dali City, Yunnan Province.Development, this paper simulates the coupling of stress field and seepage field of this slope under the rainfall condition on the basis of the finite element software Midas GTS, and applies the strength reduction method, which takes the non-convergence of finite element iterative calculation as the instability criterion of the slope, calculating the stability coefficient after coupling by numerical method, combining with the change analysis of pore water pressure and saturation, and comprehensively evaluating the change of slope stability. The simulation results show that under the rainfall conditions, the pore water pressure and saturation within the rocky slopes with and without fissures will change, and the stability coefficient of the slope will also change accordingly. The stability coefficient and matrix suction of slope will be significantly and rapidly reduced under rainfall conditions when the rainfall penetrates into the deep part of the slope through the fissures in rocky slopes with fissures. The results of this study provide a reference and basis for the engineering management of fissured rocky slopes under rainfall conditions.
Modeling the temporal and spacial dependence structure in earthquake data from different regions in Pakistan
Authors: Khan Muhammad Yousaf , Mittnik Stefan , Tahir Muhammad , Iqbal Tahir , Iqbal Talat , Shah Muhammad Ali
Published: May 2022

As Pakistan is situated in earthquake prone area and in the past many destructive earthquakes have occurred including the most destructive 1935 Quetta, and 2005 Kashmir, 2005 earthquakes. It is of vital importance to investigate the statistical properties of the earthquake temporal data of different regions of Pakistan to mitigate earthquake hazard. The present study brings novelty in the field of statistical seismology through the vast extension of the autoregressive conditional duration models. These models are applied to the earthquake temporal data of different seismic zones of Pakistan to facilitate earthquake hazard analysts.

Different specifications of the duration models were considered to parsimoniously capture the time dependency structure present in the data. We used the linear Autoregressive Conditional Duration (ACD), logarithmic ACD models, i.e., LACD1 and LACD2, Augmented Box-Cox ACD (ABACD) and Additive and Multiplicative ACD (AMACD) models. These models were applied to the earthquake temporal data of different regions of Pakistan and the most suitable in-sample fitted and out-of-sample forecasted models were chosen through various models evaluation criteria.

The obtained results suggest that the simple linear LACD2(1, 1) model appeared as the most suitable model for modeling earthquake temporal data of different zones of Pakistan. Further, the linear ACD(1, 1) models out perform the remaining considered models regarding 1-through-4 steps-ahead out-of-sample forecasting performance for both IEC and MS zones. The Burr and exponential distributions are appeared as the most appropriate error distributions in ACD(1 ,1) model by generating the forecasts for IEC and MS zones respectively. Hence, it is suggested to use the most suitable in-sample fitted LACD2(1, 1) model to parsimoniously capture the dependency structure present in the considered earthquake data of different zones of Pakistan. Further, the most appropriate out-of-sample forecasting ACD(1, 1) model is recommended to be used for forecasting the earthquake temporal data of Pakistan. The obtained results have many useful utilizations in earthquake hazard and risk mitigation studies for Pakistan.
Two-part intertrochanteric femur fractures with bisection of the lesser trochanter: an irreducible fracture pattern
Authors: Hu Sun-jun , Chang Shi-Min , Du Shou-chao , Zhang Li-zhi , Xiong Wen-feng
Published: May 2022

Objective: To introduce the clinical features of and surgical techniques for a rare type of irreducible pertrochanteric femur fracture pattern with bisection of the lesser trochanter. Methods: From Jan 2017 to Dec 2019, 357 patients with per/intertrochanteric femur fractures underwent surgery by closed reduction and internal fixation, of whom 12 patients were indentified with rare preoperative imaging features, the lesser trochanter was almost equally bisected. The main fracture pathoanatomy of these cases included: The anterior fracture line passed along the intertrochanteric line to the medial lesser trochanter and bisected it into two equal parts from mid-level of the lesser trochanteric protrusion. The proximal part of the lesser trochanter connected to the head-neck fragment and attached by the psoas major tendon, while the distal part of the lesser trochanter connected to the femoral shaft and attached by the tendon of the iliac muscle.These fractures were irreducible by a closed maneuver and were reduced with limited assistance by some devices, and short intramedullary nails were used for fixation of these fractures. The characteristics of these fracture pathoanatomy, causes of irreducibility, intraoperative techniques and clinical outcomes were summarized. Function was evaluated clinically and radiographically after a minimum of 12 months of follow-up. Results: All patients were followed up for an average of 14.2 ± 2.1 months. Clinical fracture union occurred at an average of 10.8 ± 1.5 weeks, while radiographic union occurred at an average of 12.7±1.2 weeks. No cut out of the helical blade was visible on radiographs. The average Parker-Palmer score was 6.9±1.3 (range, 5–9) at the last follow up, including 8 cases rated as excellent, 2 as good and 2 as fair. Conclusion: Two-part pertrochanteric femur fractures with bisection of the lesser trochanter have an irreducible fracture pattern with cortical locking and soft tissue incarceration. Soft tissue release and short cephalomedullary nail fixation for this fracture pattern provide stable fixation and allow early exercise. This treatment appears to have excellent outcomes in the short and medium terms.
Wind characteristics and temporal trends in eastern Paraná state, Brazil
Authors: Terassi Paulo Miguel de Bodas , Filho Washington Luiz Félix Correia , de Oliveira-Júnior José Francisco , Sobral Bruno Serafini , Galvani Emerson , Júnior Antonio Carlos da Silva Oscar , de Gois Givanildo , Biffi Vitor Hugo Rosa
Published: May 2022

The wind is one of the most important and studied variables globally, essential to several sectors, for example, energy. Therefore, this study assesses the wind regime and analysis trends in three locations within the Paraná state, Brazil. The historical series registered between 1976 and 2010 at conventional meteorological stations belonging to the Brazilian National Institute of Meteorology. For elaborating wind roses and histograms in the climatological, seasonal, and daily scales, the WRPLOT version 8.0.0 software was used. Detection was assessed using three different statistical methods (Run, Mann-Kendall, Pettitt and Sha-piro-Wilk tests) to identify trends and temporal rupture points in the stations. All statistical tests were generated based on the R software version 3.3.2. On a seasonal scale, summer and spring present the highest wind speeds (between 2–4 ms-1) in the Curitiba and Paranaguá stations due to meteorological systems in different scales as South Atlantic Subtropical Anticyclone and Frontal Systems. The Mann-Kendall test pointed out that Castro presented statistical significance in reducing wind speed, with a decrease of 0.234 ms-1 per decade for the annual scale and 0.230 ms-1 per decade during the autumn season. The ruptures indicated a decrease in wind speed in Curitiba and Paranaguá for the spring season bove 0.105 ms-1 per decade. The Pettit test showed a change point detection in the data series in Curitiba station due to urban expansion that started in the 1980s, reducing wind speed, especially in winter and spring. These trends and ruptures revealed a significant reduction in wind speed, possibly due to the interaction between natural climate changes and the increase in surface roughness resulting from changes in land use and the urbanization process.
Retrobulbar Blood Flow Parameters in Patients with Anizometropic Amblyopia
Authors: AYDIN EMRE , ÖZGÜR EREN , İNSAN AYKUT
Published: May 2022

Purpose: To compare the retrobulbar blood flow parameters between the amblyopic eye and the healthy eye of patients with anisometropic amblyopia. Methods: Peak systolic velocity (PSV) and end-diastolic velocity (EDV) of the ophthalmic artery (OA), central retinal artery (CRA) and posterior ciliary artery (PCA) were measured with color Doppler imaging, and resistivity index (RI) and pulsatility index (PI) were computed in 62 patients aged 12-40 years with anisometropic amblyopia. Results: The mean PSV of OA, CRA, and PCA in amblyopic and fellow eyes were 30.38 ± 10.34, 8.45 ± 2.27, 8.03 ± 2.77; 33.73 ± 14.46, 8.35 ± 2.05, 8.81 ± 2.77, respectively. The mean EDV of OA, CRA, and PCA in amblyopic and fellow eyes were 6.86 ± 2.64, 1.47 ± 1.59, 1.94 ± 2.03; 8.57 ± 4.30, 1.80 ± 1.73, 2.32 ± 1.20, respectively. The mean RI of OA, CRA, and PCA in amblyopic and fellow eyes were 0.77 ± 0.10, 0.85 ± 0.14, 0.78 ± 0.15; 0.75 ± 0.07, 0.79 ± 0.20, 0.74 ± 0.13, respectively. OA-PSV and OA-EDV values in the amblyopic eye were significantly lower (p < 0.05) than in the healthy eye. OA-RI values were significantly higher (p < 0.05) in the amblyopic eye than in the healthy eye. Conclusion: Considering the decrease in PSV and EDV, and the increase in RI, which are the blood flow parameters of the amblyopic eye, our study may provide guidance to focus on increasing blood flow in the treatment of amblyopia.
Source-independent quantum random number generator against detector blinding attacks
Authors: Liu Wen-Bo , Lu Yu-Shuo , Fu Yao , Huang Si-Cheng , Yin Ze-Jie , Jiang Kun , Yin Hua-Lei , Chen Zeng-Bing
Published: May 2022

Randomness, mainly in the form of random numbers, is the fundamental prerequisite for the security of many cryptographic tasks. Quantum randomness can be extracted even if adversaries are fully aware of the protocol and even control the randomness source. However, an adversary can further manipulate the randomness via detector blinding attacks, which are a hacking attack suffered by protocols with trusted detectors.
Here, by treating no-click events as valid error events, we propose a quantum random number generation protocol that can simultaneously address source vulnerability and ferocious detector blinding attacks. The method can be extended to high-dimensional random number generation. We experimentally demonstrate the ability of our protocol to generate random numbers for two-dimensional measurement with a generation speed of 0.515 Mbps, which is two orders of magnitude higher than that of device-independent protocols that can address both issues of imperfect sources and imperfect detectors.
Cost Effective and Energy Efficient VM Migration for Scheduling in Cloud Computing
Authors: Ramesh T. , Rajagopal R. , Umaselvi M. , Paul P. John
Published: May 2022

In cloud computing, to achieve proper load balancing, the cloud data center dynamically migrates and deploys VM to meet user’s requirements without degrading the service being delivered to the user. Several migration techniques are available for migrating VM from one host to another. But they fail to consider the migration cost while determining the energy consumption during migration. One of the options to reduce the power consumption of data centers is to reduce the number of idle servers, or to switch idle servers into low-power sleep states. However, the servers cannot process the requests immediately when transiting to an active state. In this paper, a cost effective and energy efficient VM migration for scheduling in cloud computing is developed. In this technique, VMs having minimum cost and minimized energy consumption are selected for migration. During load balancing, the tasks are migrated to the underutilized server if the needed current server is overloaded. Similarly, the tasks are migrated from the under-loaded server to the current server. In energy efficient scheduling, given the arrival of user requests, the VMs are scheduled such that the total energy consumption of the data center is minimized. The proposed CEEM-VM-MS technique is implemented in Cloudusim tool. In experiments, the upper threshold value for CPU size is increased and the performance metrics power consumption, number of VM migrations, response delay, and CPU utilization are measured. Results indicate that the proposed CEEM-VM-MS technique minimizes the power consumption, reduces the number of VM migrations, reduced the response delay and increases the CPU utilization.
Imposing Ratios of Outlet Flow Rates on Large Arterial Networks with Two-Element Windkessel Model: Parametric Analysis
Authors: Lo Sharp Chim Yui , McCullough J. W. S. , Coveney P. V.
Published: May 2022

Substantial effort is being invested in the creation of a virtual human — a model which will improve our understanding of human physiology and diseases and assist clinicians in the design of personalised medical treatments. A central challenge of achieving blood flow simulations at full-human scale is the development of an efficient and accurate approach to imposing boundary conditions on many outlets. A previous study proposed an efficient method for implementing the two-element Windkessel model to control the flow rate ratios at outlets. However, no study to date has examined the conditions for this approach to hold in complex geometries. Here we clarify the general role of the resistance and capacitance in this approach. We show that the error of the flow rate ratios decreases exponentially as the resistance increases. The errors fall below 4% in a simple five-outlets model and 7% in a human artery model comprising 10 outlets. Moreover, the flow rate ratios converge faster and suffer from weaker fluctuations as the capacitance decreases. Our findings also establish constraints on the parameters controlling the numerical stability of the simulations. The findings from this work are directly applicable to larger and more complex vascular domains encountered at full-human scale.