bluuebunny/crossref_metadata_2025 huggingface dataset:
paisaje filtrante del agua: Infraestructuras ecológicas remediadoras en base al Salix viminalis en la comuna de Chimbarongo
Authors: Marie Sterzik Malina
Published: July 2023

No presenta resumen.
Paisajes de la sal artesanal en Chile: articulaciones ecológicas y productivas para la resiliencia del territorio. El caso de la laguna de Boyeruca
Authors: Moreno Osvaldo , Romero Camila
Published: July 2023

No presenta resumen.
Patrimonio, proyecto y ciudad. Estudio de fuentes para la reconstrucción de cuatro casos de transformación sostenible en el centro de Santiago
Authors: Pérez Elvira , Saavedra Christian
Published: July 2023

No presenta resumen.
Repetir, Desplazar, Exponer, Bautizar…
Authors: Raschillá Maite
Published: July 2023

No presenta resumen.
Arquitectura (y) narrativa: la museografía de San Francisco de la Alameda
Authors: Hamilton Diego J.
Published: July 2023

No presenta resumen.
Computational evaluation of assembly technique influence on ballistic performance of a bullet – non-linear relation between méplat size and the drag coefficient
Authors: Piasta Krzysztof , Kupidura Przemysław , Michalski Jakub
Published: July 2023

The continuous development of production and assembly techniques gives rise to the idea of following a new approach in the small-arms ammunition design process. Commonly used intermediate cartridges were designed over 60 years ago, and their construction and assembly processes are not significantly different than what was available almost a century ago. Along with the recent development of individual protection devices and with the general availability of modern ballistic plates utilized in plate carriers type of individual armor, it sparks the necessity of designing a new, intermediate cartridge, using new assembly and technology methods. The vital aspect of the ammunition design process is a determination of the materials utilized in bullet elements and its assembly method. Therefore, there is a necessity of evaluating if different assembly techniques can provide the improved ballistic performance of a bullet. The paper includes a comparison of two differently assembled projectiles with steel penetrators: a standard Full Metal Jacket and a reverse-drawn Semi-Jacketed bullet. The designs were evaluated in terms of their external ballistic performance for specific initial conditions using 2D Computational Fluid Dynamics simulations and, separately, with a semi-empirical method. The paper aimed to assess the influence of the assembly method on the bullet’s external ballistic performance. Both calculations revealed a nonlinear relation between the projectile méplat diameter and the coefficient of drag, which indicates a limit where the méplat size reduction is beneficial. The results implicate a perspective bullet construction that would provide the user with better external ballistic performance, more consistent and precise than a standard Full Metal Jacket design.
A simulation of displacement of cutting tool holders used for turning
Authors: Mautner Viktor , Horvat Katarina , Stoić Marija , Stoić Antun
Published: July 2023

This paper gives a comparison of the deformation and deflection of two types of tool holders used in turning processes. Comparison of the deflection and stresses has been performed on the location where the highest value of deflection can be measured i.e. on the tip of the cutting insert. Selected tool holder types (TH1 and TH2) have rectangular and polygonal shank. Tool holders were 3D modelled in SolidWorks and Autodesk Inventor software packages and exposed to the loading with ANSYS structural analysis FEM software. In FEM analysis, two elements size of the network are selected (mesh size 5 and 1 mm). The simulation was carried out for five different loading values acting on the tool holder model. Obtained results confirm lower stresses and deflections on CAPTO tool holders.
Consumer Buying Behaviour towards Processed Food in Manipur, India
Authors: Soraisam Sayadee , Barker Nitin
Published: July 2023

The main objective of the study was to find out the sales promotion and consumer buying behaviour of Likla food products. The research mainly focuses on the factors like quality, consumer preference, price, service, attitudes, and consumer experience. In this study, data was collected from the consumer through a questionnaire (interview schedule). I have purposefully selected 4 blocks of Imphal East. From the 4 blocks, I have chosen 20 localities. From each block, I collected 50 samples from respondents. 200 samples are selected using convenience sampling. Using the interview schedule prepared, the 200 respondents were interviewed personally and their opinions were collected. Likert’s scale technique was used for opinion collection in the questionnaire survey. The chi-square test was used as a statistical tool. The secondary data was collected from the management. The collected data is analyzed using analytical tools like simple percentages. Finally, the main problem of sales promotion is the lack of awareness about the product i.e., advertisement. Consumer from the local areas thinks that the price of products is a little higher and the availability of service is less. The solution to these problems is, nowadays people are addicted to phones and television. By using local channels, notices, and applications can improve their advertisement. For local consumers, they can make available service stalls in nearby areas and Likla can improve its digital platform.
The Most Common Mutations in the CFTR Gene in the Population of Bosnia and Herzegovina
Authors: Mačkić-Ðurović Mirela , Kiseljaković Emina , Aganović-Mušinović Izeta , Rasumović Admir
Published: July 2023

Aims: Cystic fibrosis is an autosomal recessive multisystem disease caused by a mutation of the CFTR gene. To date, more than 1900 mutations of this gene are known. Studies have shown that the most common mutation is delF508. In Bosnia and Herzegovina, the prevalence of individual mutations in the general population has not been thoroughly studied, so this study aimed to determine the prevalence of the mutation concerning the countries of the region and the rest of the world.

Study Design: Retrospective study.

Place and Duration of Study: Thirty-nine subjects with suspected Cystic fibrosis were referred to the Center for Genetics of the Medical Faculty in Sarajevo between 2018-2020.

Methodology: 29 common CFTR gene mutations were analysed with the ELUCIGENE CF29 v2 kit (Elucigene Diagnostics, UK) using four multiplex PCR.

Results: The most common mutation in our study was the F508 deletion, present in 14 subjects (73.68%). R347P and G542X mutations were confirmed in two subjects in the heterozygous state in combination with delF508 (M) 5.26% of each of these mutations. 621+1G>T was found in a homozygous state in one subject, while in another, it was in a heterozygous state in combination with delF508(M) mutation, 10.52%. Mutation 2184 delA was found in one subject in the homozygous state with a total frequency of 5.26%.

Conclusion: Subjects with cystic fibrosis in Bosnia and Herzegovina are most often carriers of the delF508 mutation. Considering the existence of many mutations and that it is difficult to test them all, targeting the most common mutations in a clinical environment might help in approving therapy, and increasing patients’ quality of life.
Determination of Genetic Diversity of Tamarind (Tamarindus indica) Accessions in Eastern Region of Kenya Using Inter Simple Sequence Repeat (ISSR) Markers
Authors: Kidaha Mercy Liharaka , Mbathi Cornelius Wainana , Wanzala Fredah Rimberia
Published: July 2023

There is scanty information on tamarind’s genetic diversity in Easter Kenya. The objective of this study was to determine the genetic diversity of 64 tamarind accessions from Eastern Kenya using 12 Inter Simple Sequence Repeat (ISSR) markers. DNA was extracted from the young apical leaves using modified CTAB method and amplified using standard PCR.  The data collected were scored as presence (1) or absence (0) of bands then compared to the 100bp ladder and analyzed using GeneAlex and R softwares. Only seven primers produced reproducible bands. A total of 46 alleles were produced for the 7 loci with an average of 6.6 per loci. Polymorphic information content (PIC) varied from 0.72 to 0.89 and genetic diversity varied from 0.74 to 0.9. The ISSR markers revealed effective polymorphism of 40.87 to 99.46% and the band  sizes varied from 100 to 1000 bp. Analysis of Molecular Variance (AMOVA) depicted high variation within the tamarind populations at 90% and the least variation of 10% among the population. The first 3 components of Principal coordinate analysis (PCoA) contributed 40.83% of the total variation. Hierarchical cluster analysis grouped the tamarind accessions into seven major distinct groups. Tamarind accessions were different within counties with minimal variations among counties, proving that genetic diversity exists among the tamarind accessions in the Eastern region of Kenya. High genetic diversity was evident among Embu accessions and least among Masinga accessions. Diversity in tamarind can be utilized in marker-assisted breeding and primer ISSR17899A and ISSRHB11 can be explored in studying genes that code for various traits in tamarind accessions.
Influence of Cow Based Liquid Manures and Spacing on Growth and Yield of Cowpea (Vigna unguiculata L.) under Natural Farming
Authors: Sneh Kumar , Singh Vikram , George Shruti Grace
Published: July 2023

A field experiment was conducted at Crop Research Farm, Department of Agronomy, SHUATS, Prayagraj (U.P) during Kharif, 2022. The soil of the experimental plot was sandy loam in texture, nearly neutral in soil reaction (pH 7.1), organic carbon (0.75%), available N (269.96 kg/ha), available P (33.10 kg/ha), and available K (336 kg/ha). The treatments applied Combination of liquid organic manures Panchgavya and jeevamrut and three level of spacing were of Panchgavya (3% and 5%) and Jeevamrut (5% and 10%). The experiment was laid out in Randomized Block Design with twelve treatments each replicated thrice. Based on the objectives taken maximum plantheight (78.34 cm), number of total branches (4.76), plant dry weight (17.91 g/plant), seed yield (1.73 t/ha) and stover yield (3.45 t/ha) were recorded significantly higher in treatment combination of Panchagavya (5%) + Spacing 40 × 15 cm.number of pods per plant (22.99), number of seeds per pods (10.81) were recorded significantly higher in treatment combination of Panchagavya (3%) + Spacing 45 × 10 cm.
Comparative Overview of Performance of the Dryers with a Conventional Method of Drying i.e., Open Sun Drying
Authors: Yadav Rohit Kumar
Published: July 2023

Since ancient times, conventional techniques of food drying, such as sun drying, have been used.  Currently, drying methods have been developed with the latest technology to reduce the damages caused by biochemical changes, which decrease nutritional value during the drying process. Some of the typical drying methods used for food products are sun drying, solar tunnel dryer, cabinet-type solar drying, etc. While this is going on, cutting-edge technology is being created to combine several drying techniques to produce the optimum outcomes. The most recent drying techniques used in food processing technology will be covered in this study.
Effect of Different Levels of Organic Manures on Physico-Chemical Properties of Soil under Cowpea Crop in an Inceptisol of Prayagraj, Uttar Pradesh, India
Authors: Meena Arpana Kumari , Swaroop Narendra , Thomas Tarance , Singh Anurag Kumar
Published: July 2023

An experiment was conducted on “Effect of different levels of organic manures on physico-chemical properties of soil under cowpea crop in an inceptisol of Prayagraj, Uttar Pradesh, India” to observe  the combined effect of farmyard manure, Vermi Compost and Neem Cake on soil health and yield. The result showed that the application of FYM, Vermi Compost and Neem Cake had a significant and non-significant effect on soil Physico-chemical properties, respectively. The maximum bulk density (1.32 Mg m-3 and 1.35 Mg m-3 ), particle density (2.46 Mg m-3  and 2.48 Mg m-3 ), pH (7.47 and  7.49) and EC (0.251 dS m-1 and  0.248 dS m-1 )  were recorded in T1(absolute control) at 0-15 cm and 15-30 cm depth. Similarly, the maximum percentage pore space (48.92 % and 45.47 %), water holding capacity (43.96 % and  40.38 %), organic Carbon (0.49 % and  0.47 %),  Available Nitrogen ( 301.14 kg ha-1 and 294.97 kg ha-1), Available Phosphorus (30.96 kg ha-1 and 27.50 kg ha-1),  Available Potassium (196.58 kg ha-1and 188.41 kg ha-1) were recorded in T9 treatment.
Efficiency of Different Bio Stimulants on Chilli Crop under Prayagraj Agro Climatic Conditions
Authors: Yadav Anjali , Singh Devi , Wesley C. John
Published: July 2023

An experiment was conducted on “Production of Chilli Crop under Prayagraj Agro Climatic Conditions: Role of Bio Stimulants as plant growth regulators” to observed the effect of bio stimulants on growth parameters. The objective of the study is the effects of different doses bio stimulants and its role in growth, yield and quality of Chili variety TMPH-409. The experiment was laid in the randomized block design with 13 treatments and 3 replications with different combination of bio-stimulants. Under this experiment, 13 treatments were taken including control. Different bio stimulants used comprised of BIOSTAR, TERMINATOR33, STRICKER and OPERA, virtue all four at different doses of 2 mL, 2.5 mL, 3mL, 3.5 mL, 4 mL and 4.5 mL and mix with water. From the above experimental finding it may be concluded that the T9 (STRICKER – 3 mL/ L water) was found to be the best in the term of growth, yield and quality. The highest net return was found in the T9 (STRICKER – 3 mL/ L water) and the highest benifit cost ratio was found in the treatment T9 with 1.88 and found the best trestment.
A Comprehensive Assessment of Interventions in Women Cervical Cancer Screening in South Sudan
Authors: Mwanje Jolem
Published: July 2023

Introduction: The substantial impact of cervical cancer, particularly in low-resource environments like South Sudan, underscores the urgent need for preventive solutions, as access remains sparse. Contemporary treatment options while accessible, bring about severe side effects without greatly extending disease-free survival, emphasizing the importance of preventive screening, especially for adult women. The glaring absence of screening leads to women potentially suffering from progressed cervical cancer, a grim reality in South Sudan that contributes to around 12% of the female disease burden. Consequently, it is vital to examine the reach, associated elements, and health system initiatives aimed at cervical cancer screening in this region. This study intended to conduct an in-depth analysis of South Sudan's health system with a focus on understanding and evaluating the current interventions in place for cervical cancer screening among women.

Methods: The research was based on a community-oriented cross-sectional survey aimed at evaluating cervical cancer screening habits among women of childbearing age in five South Sudanese counties. The participants were women aged 26-65 years, with 575 samples in total. A four-stage random sampling procedure was followed in each stratum, focusing on half the Payams per county. Structured interviews were utilized for primary data collection, supplemented by key informant discussions for qualitative data. Descriptive statistics and log-binomial regression models were used for data analysis. The study was conducted in Torit, Magwi, Terekeka, Raja, and Aweil North, targeting women of reproductive age due to their HPV infection risk.

Results: The study found that only 11.5% of women in South Sudan had been screened for cervical cancer. Factors associated with cervical cancer screening rates included women who reported shorter waiting times for medical services (aPR=3.47 [CI=1.69-7.14]), received HPV vaccination (aPR=4.71 [CI=3.04-7.31]), kind and caring health workers (aPR=3.35 [CI=1.47-7.63]), and integrated cervical screening facilities (aPR=2.28 [CI=1.45-3.60]) had higher screening rates. However, the study found little evidence of community or institutional interventions aimed at increasing cervical cancer screening rates.

Conclusion: Based on the findings, cervical cancer screening coverage for women in South Sudan is very low, at only 11.5%. However, certain factors were found to be associated with higher screening prevalence, including shorter wait times, caring and kind health workers, and integrated screening facilities were also associated with higher screening prevalence. It is concerning that there were virtually no interventions at the institutional level to increase screening rates. These findings suggest the need for targeted interventions to improve access to screening services and strengthen health systems to increase cervical cancer screening coverage in South Sudan.
NIRS Estimation of the Nutritive Value of Megathyrsus maximus (Syn. Panicum sp.) Forages
Authors: Abreu Joadil G. de , Kazama Daniele C. da S , Peixoto Wender M. , Assis Lucas M. B. , Baldissarelli Vanessa Z. , Butzge Juliana L. , Herrera Dayenne M. , Herrera Larah D. S.
Published: July 2023

Aimed to evaluate the estimation of the nutritive value of Megathyrsus maximus (Syn. Panicum sp.) forages by near-infrared reflectance spectroscopy (NIRS). The experimental design was completely randomized with four replications. The treatments were arranged in a split-plot arrangement, with nine cultivars of M. maximus in the main plot (Aries, Atlas, Massai, Mombasa, Paredao, Kenya, Tamani, Tanzania, and Zuri) and four harvesting ages in the subplot (30, 60, 90, and 120 days). The contents of dry matter (DM), crude protein (CP), neutral detergent fiber (NDF) and acid detergent fiber (ADF), indigestible neutral detergent fiber (iNDF), and ash were evaluated. A reduction in CP and ash contents is observed with the advancement of age in all evaluated cultivars. In contrast, an increase in DM, NDF, ADF, and iNDF contents is observed. The nutritive value of the forages from the evaluated cultivars deteriorates as age increases, recommending grazing periods of less than 60 days for cattle. The NIRS estimations are excellent (R2cv > 0.95) for CP, ash, NDF, and iNDF, demonstrating the potential of this technology for analyzing the nutritive value of M. maximus forages.
Study of anatomical variations in premolars by cone beam computerized tomography in a radiologic clinic in Piauí
Authors: Sales Junior Romulo de Oliveira , Gomes Filho João Eduardo , Almeida Wanderson Carvalho de , Freitas Sérgio Antônio Pereira , Falcão Carlos Alberto Monteiro , Ferraz Maria Ângela Arêa Leão
Published: July 2023

Introduction: Root canal cleaning is the main objective of endodontic treatment and requires knowledge of the internal anatomy. The premolars are evidenced in the literature with great anatomical variations. In view of this, studies indicate that the use of Cone Beam Computed Tomography helps in the visualization of highly complex anatomy. Objective: to describe the anatomical variations in maxillary and mandibular premolars using cone beam computed tomography in a radiologic clinic in Piaui. Methods: 54 cone beam computed tomography scans with 160 premolars were used, produced using the Orthopantomograph OP300 equipment and analyzed by multiplanar reconstructions: axial, coronal and sagittal. Data regarding sex, number of roots and canals were recorded to compare and classify according to Vertucci. Results: the maxillary first pre-molars had 63.5% two roots,83.7% with one root and the mandibular pre-molars mostly with one root. Regarding the number of channels, 92.3% of the first premolars had two channels, most of them maxillary second premolars and mandibular premolars only one channel. Vertucci variations of types I, II, III and IV were verified in single-rooted elements, observing a great variation in superior elements. As for the prevalence of sex, only the first superiors showed greater variation in males. Conclusions: the upper first premolars prevailed with a great anatomical variation in relation to the other premolars with prevalence of Vertucci Type I and in males.
Mapeamento de Ciência (Artigos com RSL) e de Desenvolvimento Tecnológico (Patentes) sobre Agricultura Sustentável visando à Fome Zero (ODS2)
Authors: Vieira Jaqueline , Quintella Cristina M.
Published: July 2023

O segundo Objetivo Sustentável da ONU (ODS2), Fome Zero, foca os desafios da sociedade no combate à fome e considerando o aumento populacional até 2050. O progresso da Agricultura Sustentável é um dos gargalos cruciais, sendo essencial acompanhar e intensificar tanto o conhecimento científico, como o desenvolvimento tecnológico. O mapeamento de artigos e revisões foi feito na base Scopus com tratamento de dados pelo bibliometrix biblioshiny do R e RStudio. O mapeamento patentário foi realizado na base Worldwide Europeia por meio do Orbit Intelligence, entre 2012 e 2021. Foram mapeados 438 artigos e 6.464 famílias de patentes. Em ambos os casos, houve crescimento de cerca de 90% entre 2017 e 2021 em comparação com 2012 e 2016. O desenvolvimento tecnológico da engenharia civil cresceu 157% e outras máquinas especiais 102%, se comparados dois ciclos de cinco anos, de 2012 a 2021.
Propriedade Intelectual no Instituto Federal da Bahia: produção científica e evolução da Política de Inovação
Authors: Oliveira Igor Cássio Rocha de , Carneiro Cristine Elizabeth Alvarenga , Barbosa Eduardo Fernandes
Published: July 2023

O grau de desenvolvimento de um país reflete sua relação com a Propriedade Intelectual (PI) e suas políticas de Inovação. Com o objetivo de elucidar a pertinência dessa relação no Instituto Federal da Bahia (IFBA), o presente estudo de caso apresenta uma pesquisa exploratória, de natureza bibliográfica e documental realizada durante o período de dezembro de 2008 a fevereiro de 2022, considerando a produção científica e a evolução da política de inovação. Os dados foram coletados pela busca por pedidos de registro junto ao Instituto Nacional da Propriedade Industrial (INPI), em artigos e em documentos institucionais. Foram verificados 103 pedidos de registros, sendo 49 para registros de patentes e 46 para programas de computador. Constatou-se também que os pesquisadores que mais publicaram em revistas indexadas, tendo o IFBA como elemento de busca, não estão entre os inventores que aparecem como titulares de patentes do IFBA. Além disso, a ausência de licenciamento das PIs do IFBA demonstra que a gestão da Inovação precisa ser dirigida de maneira mais eficaz e com maior proximidade e interatividade com as demandas e realidade do mercado.
Identificação e Avaliação da Conexão Científica e Tecnológica entre os Pesquisadores Atuando em Oncologia e Medicina Nuclear Segundo a Base Lattes
Authors: Chaves Henrique Koch , Marques Fábio Luiz Navarro , Chalco Jesús Pascual Mena , Magalhães Jorge Lima de
Published: July 2023

Na era do Big Data, torna-se premente o compartilhamento aberto de dados em pesquisa, trabalho em rede e a rápida identificação de especialistas em áreas específicas. A Plataforma Lattes é o principal repositório curricular brasileiro, sendo possível extrair diversas informações de pesquisadores, como instituição onde trabalham, linhas de pesquisa, produções científicas, etc. Há limitações na plataforma, como as informações dos especialistas estarem dispostas individualmente e sem um padrão de indexação. Dessa forma, considerando a importância dos radiofármacos para a saúde pública brasileira e mundial, este trabalho objetivou identificar os especialistas mais relevantes em território brasileiro atuando no tema. Utilizou-se como estudo de caso a abordagem quantitativa para análise das informações cadastradas em câncer com especificidade em tecnécio-99m das competências essenciais na área, utilizando a ferramenta computacional ScriptLattes. Os resultados mostraram-se eficientes pela geração de conhecimento científico e tecnológico em vários níveis institucionais, podendo ser replicado em diversas áreas da ciência.
Utilização do Sistema Blockchain e sua Rastreabilidade no Agronegócio
Authors: Melotti Leonardo Marcondes Domingues , Basso Micheli , Cruvinel Guilherme Ferreira Araújo , Nascimento Renan Custódio do
Published: July 2023

Resumo
O modelo de produção e consumo de alimentos percorre uma grande cadeia logística até chegar ao consumidor final. O uso da cadeia de suprimentos prevê todas as atividades de movimentação e armazenagem, desde o momento em que um produto é adquirido até o momento do consumo, a um custo razoável. Cada dia mais, o consumidor, torna-se exigente quanto ao detalhamento dessa cadeia. Fato esse que recai sobre os objetivos deste trabalho em demostrar que a utilização da tecnologia Blockchain pode contribuir na geração de valor na cadeia alimentar. Para alcançar tal objetivo, foi realizado um estudo bibliográfico em textos acadêmicos, relacionados ao tema Blockchain e agronegócio, buscando compreender como a tecnologia pode agregar mais valor na cadeia alimentar. Ao final, constatou-se que a rastreabilidade e a transparência de transações voltadas para as commodities resultam no aumento da confiança dos utilizadores. O fato de a rastreabilidade ser acessível e de a proteção criptográfica da blockchain ser garantida evita ocorrências de má conduta e há diminuição na existência de dados falhos ou que não correspondem com a realidade.
Prospecção Tecnológica de Cabine de Pintura Industrial
Authors: Nascimento Maissa Kamylle Melo do
Published: July 2023

A pintura de um produto é crucial para o sucesso do fabricante, pois as cores são determinantes para atender às expectativas do cliente. Diante da realidade econômica de competitividade entre empresas e a evolução das tecnologias com a indústria 4.0, este trabalho teve como principal objetivo identificar o estado atual de desenvolvimento tecnológico em processo de cabine de pintura industrial a partir de uma prospecção tecnológica utilizando o banco de dados de patentes Orbit Intelligence usando as palavras-chave definidas. Foram identificadas 2.827 patentes, das quais 10,2% estão em vigor, em contrapartida, há atores que possuem esse percentual de patentes em vigor maior que 80%. No período de 2000 a 2020, obteve-se a média de 72,4 patentes/ano, percebendo-se perfis estratégicos diferentes quanto à constância de investimento. Evidenciou-se que os principais atores estão localizados nos países asiáticos e europeus. Como área relacionada, destaca-se a Engenharia Química com 73,4% no panorama geral.
Desenvolvimento de Software para Gestão de Biotérios: parceria ICT-empresa para inovação
Authors: Ferreira Eloiza , Goebel Karin , Mazzarotto Giovanny , Silveira Guilherme
Published: July 2023

O artigo apresenta a experiência do desenvolvimento de um software de gestão de biotérios em uma instituição pública e as estratégias utilizadas para colocá-lo em uso a fim de gerar inovação. A metodologia de natureza qualitativa teve abordagem predominantemente exploratória com coleta de informações. Utilizou-se da observação e análise de documentos registrados desde o início do desenvolvimento até o final da parceria comercial e de codesenvolvimento com uma instituição privada. Vários desafios para disponibilizar no mercado o software se apresentaram, como os escassos recursos e a falta de cultura tecnológica dos gestores de biotérios, além da dificuldade de encontrar um modelo de negócios viável para comercialização, visto que a maioria dos biotérios é pública. A transferência de tecnologia ainda é um desafio para uma Instituição Científica, Tecnológica e de Inovação (ICTs) no Brasil. Dessa forma, as lições aprendidas neste caso podem ser úteis para gestores e pesquisadores envolvidos com inovação.
Multimorbidity Patterns and Rheumatoid Arthritis Disease Outcomes: Findings From a Multicenter, Prospective Cohort
Authors: Dutt Sarah , Roul Punyasha , Yang Yangyuna , Johnson Tate M. , Michaud Kaleb , Sauer Brian , Cannon Grant W. , Baker Joshua F. , Curtis Jeffrey R. , Mikuls Ted R. , England Bryant R.
Published: July 2023

Objective

To determine whether unique multimorbidity patterns are associated with long‐term rheumatoid arthritis (RA) disease severity.

Methods

We conducted a cohort study within the Veterans Affairs Rheumatoid Arthritis registry. We applied previously derived multimorbidity patterns based on the presence of diagnostic codes for relevant conditions prior to enrollment using linked administrative data. Disease activity and functional status were assessed longitudinally up to 5 years after enrollment. The association of multimorbidity patterns with disease activity and functional status were assessed using generalized estimating equations models adjusting for relevant confounders.

Results

We studied 2,956 participants, of which 88.2% were male, 76.9% reported white race, and 79.3% had a smoking history. Mental health and substance abuse (β 0.12 [95% confidence interval {CI} 0.00, 0.23]), cardiovascular (β 0.25 [95% CI 0.12, 0.38]), and chronic pain (β 0.21 [95% CI 0.11, 0.31]) multimorbidity were associated with higher Disease Activity Score in 28 joints (DAS28) scores. Mental health and substance abuse (β 0.09 [0.03, 0.15]), cardiovascular (β 0.11 [95% CI 0.04, 0.17]), and chronic pain multimorbidity (β 0.15 [95% CI 0.10, 0.20]) were also associated with higher Multidimensional Health Assessment Questionnaire (MDHAQ) scores. The metabolic pattern of multimorbidity was not associated with DAS28 or MDHAQ. The number of multimorbidity patterns present was highly associated with DAS28 and MDHAQ (P trend < 0.001), and patients with all four multimorbidity patterns had the highest DAS28 (β 0.59 [95% CI 0.36, 0.83]) and MDHAQ (β 0.27 [95% CI 0.16, 0.39]) scores.

Conclusion

Mental health and substance abuse, chronic pain, and cardiovascular multimorbidity patterns are associated with increased RA disease activity and poorer functional status. Identifying and addressing these multimorbidity patterns may facilitate achieving RA treatment targets.
Water Activation in Solar‐Powered Vapor Generation
Authors: Wei Dan , Wang Chengbing , Zhang Jing , Zhao Heng , Asakura Yusuke , Eguchi Miharu , Xu Xingtao , Yamauchi Yusuke
Published: July 2023

Solar‐powered vapor evaporation (SVG), based on the liquid‐gas phase conversion concept using solar energy, has been given close attention as a promising technology to address the global water shortage. At molecular level, water molecules escaping from liquid water should overcome the attraction of the molecules on the liquid surface layer to evaporate. For this reason, it is better to reduce the energy required for evaporation by breaking a smaller number of hydrogen bonds or forming weak hydrogen bonds to ensure efficient and convenient vapor production. Many novel evaporator materials and effective water activation strategies have been proposed to stimulate rapid steam production and surpass the theoretical thermal limit. However, an in‐depth understanding of the phase/enthalpy change process of water evaporation is unclear. In this review, a summary of theoretical analyses of vaporization enthalpy, general calculations, and characterization methods is provided. Various water activation mechanisms are also outlined to reduce evaporation enthalpy in evaporators. Moreover, unsolved issues associated with water activation are critically discussed to provide a direction for future research. Meanwhile, significant pioneering developments made in SVG are highlighted, hoping to provide a relatively entire chain for more scholars who are just stepping into this field.
In Situ Filler Addition for Homogeneous Dispersion of Carbon Nanotubes in Multi Jet Fusion–Printed Elastomer Composites
Authors: Chen Jiayao , An Ran , Tey Wei Shian , Zeng Qingyun , Zhao Lihua , Zhou Kun
Published: July 2023

The dispersibility of fillers determines their effect on the mechanical properties and anisotropy of the 3D‐printed polymeric composites. Nanoscale fillers have the tendency to aggregate, resulting in the deterioration of part performance. An in situ filler addition method using the newly developed dual‐functional toughness agents (TAs) is proposed in this work for the homogeneous dispersion of carbon nanotubes (CNTs) in elastomer composites printed via multi jet fusion. The CNTs added in the TAs serve as an infrared absorbing colorant for selective powder fusion, as well as the strengthening and toughening fillers. The printability of the TA is theoretically deduced based on the measured physical properties, which are subsequently verified experimentally. The printing parameters and agent formulation are optimized to maximize the mechanical performance of the printed parts. The printed elastomer parts show significant improvement in strength and toughness for all printing orientations and alleviation of the mechanical anisotropy originating from the layer‐wise fabrication manner. This in situ filler addition method using tailorable TAs is applicable for fabricating parts with site‐specific mechanical properties and is promising in assisting the scalable manufacturing of 3D‐printed elastomers.
Psychological resilience and cortisol levels in adults: A systematic review
Authors: Aizpurua‐Perez Ibane , Arregi Amaia , Labaka Ainitze , Martinez‐Villar Arian , Perez‐Tejada Joana
Published: July 2023

Resilience or the capacity to “bend but not break” refers to the ability to maintain or regain psychobiological equilibrium during or after exposure to stressful life events. Specifically, resilience has been proposed as a potential resource for staving off pathological states that often emerge after exposure to repeated stress and that are related to alterations in circulating cortisol.

The aim of this systematic review of the literature was to gather evidence related to the relationship between psychological resilience and cortisol levels in adult humans.

An extensive systematic search was carried out following the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) method in the PubMed and Web of Science databases. In total, 1256 articles were identified and, of these, 35 peer‐reviewed articles were included in the systematic review.

We categorized findings according to (1) the short and long‐term secretion period covered by the cortisol matrices selected by studies and also according to (2) the differentiated diurnal, phasic (acute), and tonic (basal) components of the HPA output to which they refer and their relationships with resilience. Reported relationships between psychological resilience and distinct cortisol output parameters varied widely across studies, finding positive, negative, and null associations between the two variables. Notably, several of the studies that found no relationship between resilience and cortisol used a single morning saliva or plasma sample as their assessment of HPA axis activity.

Despite limitations such as the great variability of the instruments and methods used by the studies to measure both resilience and cortisol, together with their high heterogeneity and small sample sizes, the evidence found in this systematic review points to the potential of resilience as a modifiable key factor to modulate the physiological response to stress. Therefore, further exploration of the interaction between the two variables is necessary for the eventual development of future interventions aimed at promoting resilience as an essential component of health prevention.
Long‐term blood pressure patterns in midlife and dementia in later life: Findings from the Framingham Heart Study
Authors: Kim Hyun , Ang Ting Fang Alvin , Thomas Robert J. , Lyons Michael J. , Au Rhoda
Published: July 2023

INTRODUCTION

Long‐term blood pressure (BP) measures, such as visit‐to‐visit BP variability (BPV) and cumulative BP, are strong indicators of cardiovascular risks. This study modeled up to 20 years of BP patterns representative of midlife by using BPV and cumulative BP, then examined their associations with development of dementia in later life.

METHODS

For 3201 individuals from the Framingham Heart Study, multivariate logistic regression analyses were performed to examine the association between long‐term BP patterns during midlife and the development of dementia (ages ≥ 65).

RESULTS

After adjusting for covariates, every quartile increase in midlife cumulative BP was associated with a sequential increase in the risk of developing dementia (e.g., highest quartile of cumulative systolic blood pressure had approximately 2.5‐fold increased risk of all‐cause dementia). BPV was not significantly associated with dementia.

DISCUSSION

Findings suggest that cumulative BP over the course of midlife predicts risk of dementia in later life.

HIGHLIGHTS

Long‐term blood pressure (BP) patterns are strong indicators of vascular risks.

Cumulative BP and BP variability (BPV) were used to reflect BP patterns across midlife.

High cumulative BP in midlife is associated with increased dementia risk.

Visit‐to‐visit BPV was not associated with the onset of dementia.
Determination of mechanical and damping properties of hazelnut shell powder reinforced biocomposites by ultrasonic method
Authors: Oral Imran , Kocaman Suheyla , Cerit Alaaddin , Ahmetli Gulnare
Published: July 2023

This research was carried out to figure out the effect of chemical treatments of hazelnut shell powders (HSPs) on the elastic properties, ultrasonic wave velocities, and damping properties of bio‐based epoxy resin (BER) biocomposites. Natural hazelnut shells (HSs) were chemically treated using sodium hydroxide (NaOH), and acetic anhydride (AA). Then, HSs that were chemically treated with NaOH and AA, and HSs that were not subjected to chemical treatment were ground to obtain HSPs. The treated HSPs (HSP‐NaOH and HSP‐AA), and untreated HSPs were contributed to the neat BER in varied compositions such as 10–50 wt% to obtain the BER/HSP, BER/HSP‐NaOH, and BER/HSP‐AA biocomposites. The effect of untreated, and treated HSP ratios on the density, ultrasonic wave velocities, Young's modulus, Bulk modulus, Shear modulus, Poisson ratio, microhardness, and damping characteristics (attenuation coefficient, loss tangent and quality factor) of the novel HSP‐based biocomposites, was investigated by the ultrasonic pulse‐echo overlap method (PEOM). A significant increase in the density, ultrasonic wave velocities, and elastic modulus values of the biocomposites was seen compared to the neat BER. Based on the obtained elastic modulus values, the most appropriate combination ratio between the neat BER, and HSP‐NaOH was determined as 50:50.
Identification, Monitoring, and Management of Rheumatoid Arthritis–Associated Interstitial Lung Disease
Authors: Koduri Gouri , Solomon Joshua J.
Published: July 2023

Interstitial lung disease (ILD) is a frequent complication of rheumatoid arthritis (RA) that is associated with a significant increase in mortality. Several risk factors for the development of ILD in patients with RA have been identified, but ILD can still develop in the absence of these risk factors. Screening tools for RA‐ILD are required to facilitate early detection of RA‐ILD. Close monitoring of patients with RA‐ILD for progression is crucial to enable timely implementation of treatment strategies to improve outcomes. Patients with RA are commonly treated with immunomodulatory therapies, although their efficacy in slowing the progression of RA‐ILD remains the subject of debate. Clinical trials have shown that antifibrotic therapies slow decline in lung function in patients with progressive fibrosing ILDs, including patients with RA‐ILD. The management of patients with RA‐ILD should be based on multidisciplinary evaluation of the severity and progression of their ILD and the activity of their articular disease. Close collaboration between rheumatologists and pulmonologists is essential to optimize patient care.
Mean field games of energy storage devices: A finite difference analysis
Authors: Liu Fengao , Yu Mei , Wei Bo , Xiao Feng
Published: July 2023

This paper considers a mean field game of energy storage devices (ESDs) in power systems, where electrovalency is affected by the storage population. The competition processes of ESDs are characterized by a pair of coupled partial differential equations (PDEs). The so‐called mean field equilibrium (MFE) is obtained by resolving the PDEs. The resulting MFE strategy is then broadcast to all local controllers in order to independently determine a control input for each device. Since PDEs are difficult to be explicitly calculated, a pair of difference schemes are designed for approximating the exact solutions of the PDEs. Then the sufficient condition of stability is analyzed. Based on the proposed difference schemes, a difference iterative scheme is designed for numerically calculating the MFE. Some simulation results show the effectiveness of the proposed iterative schemes.
N,P‐co‐doped 2D Carbon Nanosheets for High Energy Density Zinc‐Ion Capacitors
Authors: Li Jiaxin , Gao Yanshen , Holze Rudolf , Li Shiyun , Mijowska Ewa , Chen Xuecheng
Published: July 2023

Zinc‐ion capacitors (ZICs) are regarded as highly promising candidates for electrical energy storage systems (EESs). However, some challenges must be met to achieve high energy density and long cycling life in practical applications. Herein, we report on design and preparation of 2D nanosheets of N,P‐co‐doped hierarchical porous carbon (GNPCs) by a one‐step process. Benefitting from the mesopores supporting rapid diffusive ion transport, sufficient micropores for charge storage, and high electrical conductivity enabled by N,P‐doping, the resulting GNPC cathodes for ZICs achieved a high capacity of 401 F g−1. In a complete device a high energy density of 180 Wh kg−1 was obtained at a power density of 85 W kg−1 at 0.1 A g−1. More importantly, the ZICs exhibit a good cycling stability with a capacity retention of 95 % after 10 000 cycles at a current density of 5 A g−1. Our work presents a good strategy for developing high‐performance carbon‐based cathodes for ZICs.
Ultrasound‐targeted microbubble destruction mediates PDE5i/NO integration for cavernosum remodeling and penile rehabilitation
Authors: Yang Wende , Qiu Chen , Zhai Jiancheng , Zhang Wei , Huang Chengwu , Shao Jun , Zhang Jingke , Chen Shigao , Miao Xiaoyan , Chen Peng , Wei Bo , Ren Jie , Wei Hongbo
Published: July 2023

Erectile dysfunction (ED) caused by cavernous nerve injury (CNI) is refractory to heal mainly ascribed to the adverse remodeling of the penis induced by ineffectual microvascular perfusion, fibrosis, and neurotrophins scarcity in cavernosum. Phosphodiesterase type V inhibitors (PDE5i) have been regarded as an alternative candidate drug for avoiding penile neuropathy. However, the therapeutic efficacy is severely limited due to poor accumulation under systemic medication and endogenous nitric oxide (NO) deficiency in cavernosum. Herein, an innovative liposomal microbubble (MB) loaded with both Sildenafil (one of PDE5i) and NO was designed. Ultrasound‐targeted MB destruction (UTMD)‐mediated efficient release and integration erectogenic agents into corpus cavernosum with high biosafety. On a bilateral CNI rat model, the multifunctional MB‐cooperated UTMD improved microvascular perfusion in penis, simultaneously, alleviated hypoxia and oxidative stress, indicating successful activation of NO–cyclic guanosine monophosphate pathway. Also, evaluation of the endothelial/muscular composition, intracavernosal pressure, and neural integrity in the penis proved that coordinated intervention reversed the abnormal structural remodeling and promoted the recovery of functional erection. Our work demonstrates that MB loading Sildenafil and NO combined with UTMD hold great promise to “awaken” the efficacy of PDE5i in neurogenic ED, which provided a superior option for ensuring penile rehabilitation.
Turn down the emotion, not the volume: Emotion regulation in Black and Afro‐Caribbean youth
Authors: Brown Jamar , Rueter Samuel , Presburger Alan , Gatto Alyssa J.
Published: July 2023

Black youth face marginalization at multiple levels, which can have deleterious developmental consequences. An important focus is the misrepresentation of Black emotional expression at the intersection of structural racism and clinical psychology. As efforts to incorporate anti‐racism in psychological care continue, there is a need to increase specificity to improve clinical efforts. The white hegemony for both boys and girls leads to the dehumanization of Black teens, which often leads to misdiagnosis and incomplete treatment plans.
A preventive approach: What the field of child and adolescent psychiatry can learn from neonatology
Authors: Adams Ashley
Published: July 2023

As a resident physician training in pediatrics, adult psychiatry, and child and adolescent psychiatry, I've had the opportunity to explore three different fields of medicine. While it can sometimes be challenging to navigate the differences between them, this training has allowed me to reflect on what aspects of each field I'd like to incorporate into my career. This past year I've had the chance to spend one half‐day a week as a pediatrician in the Women and Infants’ neonatal intensive care unit (NICU) follow‐up clinic while spending the rest of my week working on various inpatient psychiatry units at Bradley Hospital. My time spent working with the families in the NICU follow‐up clinic has led me to envision a similar preventative care model for children and families at high risk for mental health concerns.
Keep your eye on…
Authors: Knopf Alison
Published: July 2023

The value of foster care instead of orphanage care

The benefits of high‐dose Vitamin D in first two years of life
APA's recent advisory on social media use in children under age 13: An example of dissemination science at its best
Authors: Walters Anne S.
Published: July 2023

Social media has become an integral part of our daily lives. As its influence grows, so too have concerns about the effect on mental health, particularly for children. This newsletter and the commentaries from month to month have tackled this subject with varying viewpoints. Last month we discussed the recent statistics on mental health in teen girls and how social media may contribute. Nevertheless, our goal has been to present a balanced viewpoint that avoids demonizing social media.
A case report: The first show phenomenon in the treatment of spinal cord injury with Regentime procedure using autologous bone marrow‐derived stem cells
Authors: Boulos Rita T. , Nemer Lea I. , Mansour Vanessa J. , Najjoum Cynthia F. , Asmar Elsa A. , Abi Chahine Nassim H.
Published: July 2023

Key Clinical Message

Promising outcomes are shown in this case report using the Regentime procedure and autologous stem cells to treat spinal cord injury. The observed “First Show Phenomenon” provides valuable insights into the therapy's potential for spinal cord injury.

This case report demonstrates “the first show phenomenon” following Regentime stem cell therapy applied to a spinal cord injury patient. A 40‐year‐old gentleman sustained a ballistic injury at the level of T9, resulting in complete bilateral motor and sensory loss from T9 and below. He was treated with autologous bone marrow‐derived mononuclear stem cells injected into his spinal canal 2.5 years after his injury. Follow‐up during the first‐week posttransplantation showed early symptom improvement termed “the first show phenomenon.” He regained sensation to light touch in his lower limbs by the end of week 1 and reported no serious implications or complications.
Anesthetic management for inhibiting sympathetic activation in an adolescent patient diagnosed with catecholaminergic polymorphic ventricular tachycardia and undergoing left cardiac sympathetic denervation: A case report
Authors: Kwak Kyung‐Hwa , Do Young‐Woo , Yu Taeyoung , Oh Jinyoung , Byun Sung‐Hye
Published: July 2023

Key Clinical Message

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a genetic disorder in which catecholamine release during exercise or emotional stress cause fatal tachyarrhythmias. In this paper, we discuss methods to minimize the sympathetic stimulation that can occur during the perioperative period in patients undergoing left cardiac sympathetic denervation to surgically treat CPVT.