bluuebunny/crossref_metadata_2025 huggingface dataset:
Analyzing Search Topology Without Running Any Search: On the Connection Between Causal Graphs and h+
Authors: Hoffmann J.
Published: July 2018

The ignoring delete lists relaxation is of paramount importance for both satisficing and optimal planning. In earlier work, it was observed that the optimal relaxation heuristic h+ has amazing qualities in many classical planning benchmarks, in particular pertaining to the complete absence of local minima. The proofs of this are hand-made, raising the question whether such proofs can be lead automatically by domain analysis techniques. In contrast to earlier disappointing results -- the analysis method has exponential runtime and succeeds only in two extremely simple benchmark domains -- we herein answer this question in the affirmative. We establish connections between causal graph structure and h+ topology. This results in low-order polynomial time analysis methods, implemented in a tool we call TorchLight. Of the 12 domains where the absence of local minima has been proved, TorchLight gives strong success guarantees in 8 domains. Empirically, its analysis exhibits strong performance in a further 2 of these domains, plus in 4 more domains where local minima may exist but are rare. In this way, TorchLight can distinguish ``easy'' domains from ``hard'' ones. By summarizing structural reasons for analysis failure, TorchLight also provides diagnostic output indicating domain aspects that may cause local minima.
The Opposite of Smoothing: A Language Model Approach to Ranking Query-Specific Document Clusters
Authors: Kurland O. , Krikon E.
Published: July 2018

Exploiting information induced from (query-specific) clustering of top-retrieved documents has long been proposed as a means for improving precision at the very top ranks of the returned results. We present a novel language model approach to ranking query-specific clusters by the presumed percentage of relevant documents that they contain. While most previous cluster ranking approaches focus on the cluster as a whole, our model utilizes also information induced from documents associated with the cluster. Our model substantially outperforms previous approaches for identifying clusters containing a high relevant-document percentage. Furthermore, using the model to produce document ranking yields precision-at-top-ranks performance that is consistently better than that of the initial ranking upon which clustering is performed. The performance also favorably compares with that of a state-of-the-art pseudo-feedback-based retrieval method.
Policy Invariance under Reward Transformations for General-Sum Stochastic Games
Authors: Lu X. , Schwartz H. M. , Givigi S. N.
Published: July 2018

We extend the potential-based shaping method from Markov decision processes to multi-player general-sum stochastic games. We prove that the Nash equilibria in a stochastic game remains unchanged after potential-based shaping is applied to the environment. The property of policy invariance provides a possible way of speeding convergence when learning to play a stochastic game.
Adjuvant Subcutaneous Trastuzumab for HER2-Positive Early Breast Cancer: Subgroup Analyses of Safety and Active Medical Conditions by Body Weight in the SafeHer Phase III Study
Authors: Jung Kyung Hae , Ataseven Beyhan , Verrill Mark , Pivot Xavier , De Laurentiis Michelino , Al-Sakaff Nedal , Lauer Sabine , Shing Mona , Gligorov Joseph , Azim Hamdy A.
Published: July 2018

Background

This SafeHer subgroup analysis assessed the safety of fixed-dose subcutaneous trastuzumab (H SC) as an adjuvant therapy in HER2-positive early breast cancer (EBC) by body weight.

Patients and Methods

Patients with HER2-positive EBC not previously treated with anti-HER2 therapy received H SC 600 mg (every 3 weeks for 18 cycles), with neoadjuvant or adjuvant chemotherapy or without adjuvant chemotherapy. Adverse events (AEs) were assessed throughout treatment and at final follow-up (28 ±5 days after last treatment). Subgroups were categorized by body weight, Asian origin, and chemotherapy administration. All analyses were descriptive.

Results

Of 2,577 patients enrolled, 2,573 received ≥1 dose of study medication and were included in this safety analysis. Median body weight at baseline was 67.0 kg (range 33.6–150.0 kg). Any-grade AEs occurred in 88.7% (2,282/2,573) of the overall population, versus 87.1% (590/677) of the lowest bodyweight quartile (≤59 kg), 90.0% (561/623) of the highest quartile (>77 kg), and 86.5% (327/378) of the Asian population. Grade ≥3 AEs occurred in 23.2% (596/2,573) of the overall population, 17.9% (121/677) of the lowest bodyweight quartile, 26.8% (167/623) of the highest quartile, and 15.3% (58/378) of the Asian population. The highest bodyweight quartile had the highest incidence of medical conditions at baseline (highest quartile, 75.6%; lowest quartile, 56.1%).

Conclusion

These data support the use of fixed-dose H SC as an adjuvant therapy in HER2-positive EBC and confirm the comparable safety profile of H SC in patients with low body weight or of Asian origin versus the overall population in SafeHer. ClinicalTrials.gov: NCT01566721.

Implications for Practice

The safety profile of fixed-dose subcutaneous trastuzumab (H SC) was comparable between patients in the lowest bodyweight subgroup and the overall patient population, and also between patients of Asian origin (of whom a higher proportion often fall within the lower bodyweight quartiles) and the overall population. The safety data from this SafeHer subgroup analysis therefore support the use of fixed-dose H SC 600 mg administered every 3 weeks as an adjuvant therapy for patients with HER2-positive early breast cancer across different bodyweight subgroups and in the Asian patient population.
Selection of Protein Kinase Inhibitors Based on Tumor Tissue Kinase Activity Profiles in Patients with Refractory Solid Malignancies: An Interventional Molecular Profiling Study
Authors: Labots Mariette , Van der Mijn Johannes C. , Dekker Henk , Ruijter Rita , Pham Thang V. , Van der Vliet Hans J. , Van der Hoeven Jacobus J.M. , Meijer Gerrit A. , Verheul Henk M.W.
Published: July 2018

Lessons Learned

Clinically applicable tools are needed for treatment selection and repurposing of available protein kinase inhibitors (PKIs) in patients with advanced solid tumors refractory to standard treatment. Using a tyrosine kinase peptide substrate microarray, observed inhibitory activity in vitro could not sufficiently predict clinical benefit of treatment with the selected PKI.

Background

This exploratory molecular profiling study determined the feasibility and benefit of the selection of protein kinase inhibitors (PKIs) based on kinase activity profiling in patients with refractory solid malignancies.

Methods

Adult patients with biopsy-accessible refractory solid tumors were eligible. Per patient, the inhibitory potency of sunitinib, dasatinib, erlotinib, sorafenib, everolimus, and lapatinib was determined in tumor lysates from fresh biopsies using a tyrosine kinase peptide substrate microarray. The most active PKI in this in vitro assay was selected for treatment.

Results

Thirteen patients were enrolled in the feasibility part and underwent tumor biopsy. Of 12 patients in whom kinase activity profiling was performed, 11 started treatment with a selected PKI: dasatinib in 8, sunitinib in 2, and erlotinib in 1 patient(s). Eight patients were evaluable for response. One patient had stable disease (SD) >4 months on sunitinib; one patient had SD at 6 weeks but progressive disease (PD) at 12 weeks. The remaining patients had PD after 6 weeks of treatment.

Conclusion

Kinase inhibition profiles of multiple PKIs can be reliably determined using fresh tumor biopsies from patients with refractory solid tumors. However, the current in vitro microarray selection approach insufficiently predicted clinical benefit of PKI treatment in these patients.
Study of laparoscopic repair of abdominal incisional hernia
Authors: Mangam Nilesh P. , Bodade Ritesh M. , Dhurve Asmita S. , Awasarmol Sumeet , Jahagirdar Deepa P. , Gajbhiye Raj N.
Published: July 2018

Background: An incisional hernia is defined as any abdominal wall gap with or without bulge in the area of postoperative scar perceptible or palpable by clinical examination or imaging. It occurs in about 3 to 20 percent of patients undergoing laparotomy. Open hernia repair methods have an increased incidence of wound infections and wound-related complications. These problems have been overcome by laparoscopy. The placement of a large mesh by laparoscopy allows for an even distribution of forces along the surface area of the mesh, which account for the strength of the repair and the decreased recurrence rates associated with it. The merits of the laparoscopic approach are decreased rates of recurrence, reduced risks of wound complications. The aims and objective of this study were to evaluate etiological factors of incisional hernia, various techniques of laparoscopic repair of incisional hernia, and to investigate the influence of laparoscopic approach on hospital stay, complications associated with the procedure and recurrence rates.Methods: In this hospital based prospective study, total 40 cases of incisional hernia were studied which were operated laparoscopically and followed up over period of two years.Results: Incisional hernia occurrence was common in females (80%) with commonly observed risk factor was postoperative wound related complications (28 cases) and obesity (22 cases). Infraumbilical midline incision (67.5%) and supraumbilical midline incision (27.5%) was most commonly responsible for incisional hernia occurrence. LSCS was most commonly responsible for incisional hernia occurrence (45%) followed by laparotomy for various indications (27.5%). Intraperitoneal onlay mesh repair of single defect without anatomical repair was most common modality of laparoscopic repair (70%). Early postoperative pain (20%) and prolonged ileus (17.5%) was the most common complication observed. Average hospital stay was 4.22 days.Conclusions: Postoperative wound related complications are important risk factor for incisional hernia. Laparoscopic repair of incisional hernia is better choice in view of reduced wound related complications, post-operative pain and hospitals stay.
Assessment of prevalence of sexually transmissible infections among voluntary blood donors and its comparison with replacement donors at Hassan Institute of Medical Science, Hassan, Karnataka, India
Authors: C. B. Bindu , H. C. Lokesh , R. Purushotham
Published: July 2018

Background: Hepatitis B virus, Hepatitis C virus and Human immunodeficiency virus (HIV) are important STDs which can be transmissible to the recipients of blood transfusion. The aim of the present study is to study the seroprevalence of HIV, HBV and HCV infection in the blood among voluntary and replacement donors in HIMS Hassan during 2010 to 2012.Methods: A retrospective study was conducted at blood bank of HIMS, Hassan for the years 2010 to 2012. The donors with Hemoglobin>12gm% for both sexes, weight >50 kg, no history of chronic illness, hepatitis, high risk behaviours were included in the study. All the blood samples collected were screened for HIV, HBV and HCV using ELISA kits. All the blood samples were sent to NACO (national AIDS control organization) and subjected to NAT (nucleic acid test) for detection of antigens. Results compared for both voluntary and replacement donors.Results: Total of 10938 blood donors screened. Majority of the donors were males 95.8% (10484) and belonged to voluntary group 72.8% (7971). The total prevalence of STDS were 0.61% (67). The prevalence of HBV, HCV and HIV was 0.47% (51), 0.04% (4) and 0.11% (12) respectively. Prevalence of STDs was higher among voluntary donors 0.57% (62) compared to replacement donors 0.05 % (5). Statistically significant difference was observed in HBV prevalence in voluntary and replacement donors.Conclusions: Most common STDs in blood donors was HBV followed by HIV and HCV. STDs were mainly seen in voluntary donors compared to replacement donors. Majority of the donors were males.
Profile of acute upper gastro intestinal bleed: a referral hospital-based study in sub Himalayan region
Authors: C. M. Shyamsundar , Sharma Guru Dutt , Rana Baldev Singh
Published: July 2018

Background: Acute upper gastrointestinal bleeding (UGIB) is one of the most common medical emergencies and remains a major cause of morbidity and mortality. We are likely to see more of it in coming years with ageing population, patients with liver disease, increasing use of NSAIDs, single or multiple antithrombotic agents and novel anticoagulants, the present study was designed with the aim to assess the clinical profile of UGIB presenting to the Department of Medicine in sub Himalayan region.Methods: Study done over 12 months included all patients presenting with acute hematemesis and/or melena. Detailed history, clinical examination, blood tests and Upper GI Endoscopy was done in all patients.Results: One hundred seventy-five patients were included in the study, 129 (73.7%) were males. The commonest age group was 41-60 years contributing to 44%, male to female ratio 2.8:1. The commonest presentation was melena, patients with hematemesis presented earlier, with mean duration 1.46 days. 42.3% of patients were hemodynamically unstable at admission. The mean hemoglobin (Hb) was 8.224±2.78 g%.  The cause of bleed was shared by ulcer, varices, non-ulcer non-variceal approximately 1/3rd each, major cause being ulcer in 39.4%. Varices was common in age 30-40 yrs, ulcer in age 51 to 70 years.Conclusions: UGI bleed was more frequent in males age between 41-60 yrs, peptic ulcer being the leading cause in our study, presence of signs of liver failure were associated with varices.
Reasons for default and death among tuberculosis cases treated under revised national tuberculosis control program in selected tuberculosis units of Bangalore urban district of Karnataka state
Authors: M. P. Srinath
Published: July 2018

Background: Tuberculosis (TB) is a disease of great antiquity. Mycobacterium tuberculosis is a formidable pathogen. Tuberculosis still remains a worldwide problem, despite the facts that proper medications are available to treat the condition. Defaulting from the treatment is a serious issue in the treatment failure. The current study was undertaken to understand the default rate, death and its reasons among the TB patients who underwent treatment in two selected DOTS centre at Bangalore Urban district of Karnataka state.Methods: A cross-sectional study was conducted on 160 default patients treated under RNTCP at two randomly selected TB centres. The interview was conducted using a semi-structured questionnaire. Patient's relatives were interviewed in case of deaths. Appropriate statistics were used to find the significance.Results: Among the total study subjects, the 75% of the cases were males, 71.9% were in the age group 15-44 years. More than 46% of the patients were registered in category-1. The study observed that 70% of the patients defaulted during the continuation phase and only 30% defaulting was observed in the initial phase. Migration, side effects of the drugs and alcohol addiction were the major reasons for discontinuing from therapy. Maximum death (52%) was observed among Cat-1 followed by Cat-2 and the highest death rate was observed among >45 years age group.Conclusions: The study concludes that the default was prevalent among the study population, migration and untoward effects of the drugs were the important factors of default.
Repositorio del Instituto Nacional de Pediatría
Authors: Serrano Sierra Alejandro , Reynés Manzur José Nicolás
Published: July 2018

Este año el Instituto Nacional de Pediatría al contar con su Repositorio Institucional, se consolida como el primer Instituto Nacional de Salud con una plataforma digital en la que se preserva, almacena y archiva, de acuerdo con estándares internacionales, toda la producción de la investigación científica.
Hipotiroidismo congénito primario y neurodesarrollo: un enfoque terapéutico integral
Authors: Díaz Pérez Elda Josefina , Sánchez Pérez María del Carmen , Moreno Macías Hortensia , Echeverría Arjonilla Juan Carlos , Rivera González Iván Rolando , Calzada León Raúl , Ruiz-Reyes María de la Luz , Ontiveros Mendoza Esperanza , Altamirano Bustamante Nelly , Mandujano Valdés Mario Antonio
Published: July 2018

INTRODUCCIÓN: Los pacientes con hipotiroidismo congénito primario tienen menor desarrollo cognitivo y psicomotor comparados con los hermanos sanos o con grupos control (5 a 25 puntos por debajo), por lo que constituyen un desafío para el sector salud. OBJETIVO: Evaluar la función cognitiva de niños con hipotiroidismo congénito primario como respuesta a un tratamiento integral transfuncional. MATERIAL Y MÉTODOS: Estudio observacional, analítico, longitudinal y prospectivo efectuado en una cohorte (2003-2004) de niños con hipotiroidismo congénito primario tratados en el servicio de Endocrinología y en el Laboratorio de Seguimiento del Neurodesarrollo del Instituto Nacional de Pediatría. Se evaluaron con la Escala de Inteligencia de Wechsler para preescolar y primaria (WPPSI) a los 4, 5 y 6 años. Se obtuvo el coeficiente intelectual total, verbal y ejecutivo por puntuaciones directas, normalizadas y a edades escalares de los procesos cognitivos de atención, memoria y conceptualización. RESULTADOS: Se estudiaron 32 pacientes (72% femeninos) con hipotiroidismo congénito primario [53% por agenesia tiroidea y 47% con ectopia (nódulo sublingual)] en tratamiento con levotiroxina. En el coeficiente intelectual total a los cuatro años, 12% tuvieron puntuaciones limítrofes que persistieron hasta los 6 años y 12% tuvieron deficiencia mental que mejoró a los 6 años. En dos tercios el coeficiente intelectual total fue normal, en ellos, un tercio fue normal brillante o superior según la clasificación de WPPSI. La memoria auditiva y la conceptualización fueron los procesos más afectados en la trayectoria cognitiva. Las edades escalares estimadas fueron inferiores a la edad cronológica. La trayectoria cognitiva a los 6 años se predijo a los 4 años. Los factores de riesgo fueron: agenesia tiroidea, inicio tardío del tratamiento y dosis hormonales altas. Fungieron como factores protectores la participación materna, el nivel alto de estimulación en el hogar y la mejor condición socioeconómica.CONCLUSIONES: La variabilidad de la evolución cognitiva en pacientes con hipotiroidismo congénito permitió caracterizar los factores de riesgo y de protección para definir la intervención cognitiva temprana en niños. PALABRAS CLAVE: Procesos mentales; cognición; niño preescolar; hipotiroidismo congénito; factores de riesgo; factores de protección; factores socioeconómicos.
Quiste esplénico congénito complicado en un niño
Authors: Flores-Pérez Patricia , Hernández Rodríguez María José , Luis Huertas Ana Lourdes , Albi Rodríguez Gustavo
Published: July 2018

INTRODUCCIÓN: Los quistes esplénicos aislados son raros en niños y potencialmente graves y casi siempre difíciles de diagnosticar. CASO CLÍNICO: Paciente de 5 años, traído a urgencias por fiebre alta, dolor abdominal y vómito. Reporte hematológico: leucocitosis con elevación de reactantes de fase aguda, hemocultivo negativo y coprocultivo positivo para Salmonella serogrupo D. En la radiografía de tórax se objetivó infiltrado basal izquierdo y derrame pleural; en la ecografía abdominal se detectó lesión quística intraesplénica de gran tamaño. Con el diagnóstico de absceso gigante del bazo se pautó tratamiento antibiótico intravenoso y drenajes percutáneos repetidos hasta la intervención quirúrgica definitiva con extirpación quística parcial y fenestración de la cápsula. En el cultivo del absceso creció una Salmonella del mismo serogrupo. El análisis anatomopatológico de la pieza fue compatible con quiste epitelial primario. CONCLUSIONES: Como parte del diagnóstico diferencial de cualquier paciente con signos sugerentes de afectación en el hipocondrio izquierdo deben considerarse los quistes esplénicos. En los últimos años ha habido grandes avances en su tratamiento; en pacientes pediátricos suele ser conservador. PALABRAS CLAVE: Quiste epitelial; absceso esplénico; esplenectomía; niños
Image synthesis with neural networks for traffic sign classification
Authors:   NRU Higher School of Economics, Shakhuro V. , Konushin A. ,   NRU Higher School of Economics,   Lomonosov Moscow State University
Published: July 2018

In this work, we research the applicability of generative adversarial neural networks for generating training samples for a traffic sign classification task. We consider generative neural networks trained using the Wasserstein metric. As a baseline method for comparison, we take image generation based on traffic sign icons. Experimental evaluation of the classifiers based on convolutional neural networks is conducted on real data, two types of synthetic data, and a combination of real and synthetic data. The experiments show that modern generative neural networks are capable of generating realistic training samples for traffic sign classification that outperform methods for generating images with icons, but are still slightly worse than real images for classifier training.
New secure QIM-based information hiding algorithms
Authors:   Samara National Research University, Mitekin V. ,   Image Processing Systems Institute оf RAS – Branch of the FSRC “Crystallography and Photonics” RAS, Fedoseev V. ,   Samara National Research University,   Image Processing Systems Institute оf RAS – Branch of the FSRC “Crystallography and Photonics” RAS
Published: July 2018

The paper proposes two information hiding algorithms for multimedia based on Quantization Index Modulation (QIM): IM-QIM and SIM-QIM. They are designed to prevent a statistical attack which is able to restore a secret key using the correlation between key bits and multimedia data samples. To obtain the required security, we use a correlation immune embedding function, which guarantees statistical independence between the watermarked data and the key. The proposed algorithms are described for the case of spatial embedding in images but the algorithms can also be used to hide information in any multimedia data source in spatio-temporal and spectral domains. The results of the experimental investigation have confirmed that the algorithms developed provide the required security against a statistical attack and also have shown that the algorithms do not introduce additional distortions compared with the conventional QIM method. However, the experiments have also shown that the new algorithms are less robust against additive noise and JPEG compression.
A real-time semantic segmentation algorithm for aerial imagery
Authors:   State Research Institute of Aviation Systems, Blokhinov Y. , Gorbachev V. ,   State Research Institute of Aviation Systems, Rakutin Y. ,   State Research Institute of Aviation Systems, Nikitin A. ,   State Research Institute of Aviation Systems
Published: July 2018

We propose a novel effective algorithm for real-time semantic segmentation of images that has the best accuracy in its class. Based on a comparative analysis of preliminary segmentation methods, methods for calculating attributes from image segments, as well as various algorithms of machine learning, the most effective methods in terms of their accuracy and performance are identified. Based on the research results, a modular near real-time algorithm of semantic segmentation is constructed. Training and testing is performed on the ISPRS Vaihingen collection of aerial photos of the visible and IR ranges, to which a pixel map of the terrain heights is attached. An original method for obtaining a normalized nDSM for the original DSM is proposed.
Trigonometric series in orthogonal expansions for density estimates of deep image features
Authors:   National Research University Higher School of Economics, Savchenko A.
Published: July 2018

In this paper we study image recognition tasks in which the images are described by high dimensional feature vectors extracted with deep convolutional neural networks and principal component analysis. In particular, we focus on the problem of high computational complexity of a statistical approach with non-parametric estimates of probability density implemented by the probabilistic neural network. We propose a novel statistical classification method based on the density estimators with orthogonal expansions using trigonometric series. It is shown that this approach makes it possible to overcome the drawbacks of the probabilistic neural network caused by the memory-based approach of instance-based learning. Our experimental study with Caltech-101 and CASIA WebFace datasets demonstrates that the proposed approach reduces the error rate by 1–5 % and increases the computational speed by 1.5 – 6 times when compared to the original probabilistic neural network for small samples of reference images.
Noise stability of signal reception algorithms with multipulse pulse-position modulation
Authors:   Voronezh State University, Parfenov V. , Golovanov D. ,   Voronezh State University
Published: July 2018

An algorithm for estimating time positions and amplitudes of a periodic pulse sequence from a small number of samples was proposed. The number of these samples was determined only by the number of pulses. The performance of this algorithm was considered on the assumption that the spectrum of the original signal is limited with an ideal low-pass filter or the Nyquist filter, and conditions for the conversion from one filter to the other were determined. The efficiency of the proposed algorithm was investigated through analyzing in which way the dispersion of estimates of time positions and amplitudes depends on the signal-to-noise ratio and on the number of pulses in the sequence. It was shown that, from this point of view, the efficiency of the algorithm decreases with increasing number of sequence pulses. Besides, the efficiency of the proposed algorithm decreases with decreasing signal-to-noise ratio. It was found that, unlike the classical maximum likelihood algorithm, the proposed algorithm does not require a search for the maximum of a multivariable function, meanwhile characteristics of the estimates are practically the same for both these methods. Also, it was shown that the estimation accuracy of the proposed algorithm can be increased by an insignificant increase in the number of signal samples. The results obtained may be used in the practical design of laser communication systems, in which the multipulse pulse-position modulation is used for message transmission.
Angular momentum density of a circularly polarized paraxial optical vortex
Authors:   Image Processing Systems Institute оf RAS – Branch of the FSRC “Crystallography and Photonics” RAS, Kotlyar V. ,   Samara National Research University, Kovalev A. ,   Image Processing Systems Institute оf RAS – Branch of the FSRC “Crystallography and Photonics” RAS,   Samara National Research University
Published: July 2018

We obtain general analytic expressions for the angular momentum density of a vectorial circularly polarized paraxial optical vortex. It is shown that for any vortex field with the rotational symmetry and circular polarization, an effect of the “angular tractor” takes place, which means that the flow of light energy rotates around the optical axis clockwise or counter-clockwise at different radii in the beam cross section. It is also shown that on the circles of these radii in the beam cross section, the axial component of the angular momentum density of the vortex light field changes its sign. Thus, microparticles trapped in the vortex beam at different radii will rotate either clockwise or counterclockwise.
Metapoznanie nasila depresję poprzez cechę lęku: badania w populacji osób zdrowych psychicznie
Authors: Cichoń Ewelina , Kryciński Radosław , Florkowski Marcin , Szczepanowski Remigiusz
Published: July 2018

Previous studies show that maladaptive metacognitive beliefs may constitute the psychopathological core of anxiety and depression. Recent findings also indicate that anxiety exacerbates the severity of depression. We investigated the hypothesis that anxiety mediates the relationship between faulty metacognitive beliefs and depressive symptoms in normal subjects. Two hundred and eight normal participants completed the Metacognitions Questionnaire (MCQ), the State-Trait Anxiety Inventory(STAI), and the Beck Depression Inventory (BDI). We performed mediation analysis to explore the relationships between metacognition, depression, and trait anxiety as a mediator. Our study showed that positive beliefs about worry, negative beliefs about uncontrollability and danger, low cognitive confidence, and negative beliefs about the need to control thoughts, and cognitive self-consciousness were mediated by the level of anxiety associated withthe severity of depression. Moreover, the mediation analysis indicated that only cognitive confidence beliefs directly influenced the intensity of depressive symptoms.
Wsparcie społeczne dziadków i komunikowanie się z rówieśnikami jako predyktory prężności u adolescentów z rodzin samotnych matek
Authors: Napora Elżbieta
Published: July 2018

In the research paradigm focused on the stress-loaded functioning of single-mother families it has been observed that the efficiency of coping with stress depends on many factors, among which social support is one of the most important. Research results show that a higher level of social support is usually associated with more positive indicators of the functioning of an individual. On the basis of this assumption it was expected that social support provided by grandparents would be a significant predictor of mental resilience in adolescent grandchildren from single-mother families – also in conditions differentiated by household type: living with or without grandparents. Studies performed on a sample of 278 adolescents with the Berlin Social Support Scales (BSSS), the Adolescent–Peer Communication Scale, and the Resilience Measurement Scale (SPP-18) have shown that grandparental social support is not the only predictor of adolescents’ functioning.
The Polish adaptation of the engagement in meaningful activities survey (EMAS)
Authors: Bożek Agnieszka , Tokarz Aleksandra
Published: July 2018

This study aimed to determine the psychometric properties of the Polish version of the Engagement in Meaningful Activities Survey (EMAS; B. Goldberg, Brintnell, & J. Goldberg), which measures engagement in meaningful activities, understood as activities that serve a purpose significant from a personal or cultural perspective. We present definitions of key concepts, previous research related to the survey, and preliminary research on the Polish version of the survey. The study was conducted on a sample of 237 individuals: employees of cultural institutions, care associations, and corporations as well as teachers working in special schools and high schools. The results indicate a high reliability of the tool (Cronbach’s α = .88). They also reveal relations between engagement in meaningful activities and variables such as meaningfulness of work (r = .65) and job satisfaction (r = .65), and differences across professions in the level of engagement in meaningful activities.
Understanding the Monoclonal Antibody Disposition after Subcutaneous Administration using a Minimal Physiologically based Pharmacokinetic Model
Authors: Varkhede Ninad , Forrest Laird
Published: July 2018

Purpose: Monoclonal antibodies (mAbs) are commonly administered by subcutaneous (SC) route. However, bioavailability is often reduced after SC administration. In addition, the sequential transfer of mAbs through the SC tissue and lymphatic system is not completely understood. Therefore, major objectives of this study were a) To understand absorption of mAbs via the lymphatic system after SC administration using physiologically based pharmacokinetic (PBPK) modeling, and b) to demonstrate application of the model for prediction of SC pharmacokinetics (PK) of mAbs. Methods: A minimal PBPK model was constructed using various physiological parameters related to the SC injection site and lymphatic system. The remainder of the body organs were represented using a 2-compartment model (central and peripheral compartments), with parameters derived from available intravenous (IV) PK data. The IV and SC clinical PK data of a total of 10 mAbs were obtained from literature. The SC PK data were used to estimate the lymphatic trunk-lymph node (LN) clearance. Results: The mean estimated lymphatic trunk-LN clearance obtained from 37 SC PK profiles of mAbs was 0.00213 L/h (0.001332 to 0.002928, 95% confidence intervals). The estimated lymphatic trunk-LN clearance was greater for the mAbs with higher isoelectric point (pI). In addition, the estimated clearance increased with decrease in the bioavailability. Conclusion: The minimal PBPK model identified SC injection site lymph flow, afferent and efferent lymph flows, and volumes associated with the SC injection site, lymphatic capillaries and lymphatic trunk-LN as important physiological parameters governing the absorption of mAbs after SC administration. The model may be used to predict PK of mAbs using the relationship of lymphatic trunk-LN clearance and the pI. In addition, the model can be used as a bottom platform to incorporate SC and lymphatic in vitro clearance data for mAb PK prediction in the future.
Évolution des méthodes d'enrichissement de la forêt dense de la Côte-d'Ivoire. Seconde partie
Authors: Bergeroo Campagne B.
Published: July 2018

De nombreuses méthodes ont été expérimentées depuis 1950 en Côte d'Ivoire, principalement dans les forêts de Yapo et du Banco, afin de déterminer les moyens les plus efficaces d'enrichir les forêts pluviales de ce pays.L'auteur passe ici en revue les différentes méthodes : - artificielles (plantations rapprochées, plantations transversales diversifiées) ; naturelles (basées sur la régénération naturelle des essences de valeur) ; mixtes (régénération naturelle et plantations complémentaires). Il apparaît finalement que les méthodes mixtes sont les mieux adaptées, en général, aux forêts humides de Côte d'Ivoire.La deuxième partie de ce document est publiée ci-après.
Les plantations de Limba au Moyen Congo
Authors: Tariel J. , Groulez J.
Published: July 2018

L'exploitation du Limba a fortement augmenté au cours de la dernière décennie et, au Moyen Congo, dépasse largement le pouvoir de reconstitution des forêts.Les plantations destinées à combler ce déficit ont été entreprises à partir de 1950 et atteignent aujourd'hui 700 hectares par an (1.729 acres). L'expérience acquise au cours de cette période a permis de déterminer la technique la plus adaptée à cette espèce, le taux de croissance et de calculer le coût des plantations.
Bingöl Koşullarında Bazı Burçak (Vicia ervilia (L.) Willd) Genotiplerinin Tohum Verimi ve Kalite Özelliklerinin Belirlenmesi
Authors: Kökten Kağan , Kaplan Mahmut , Seydoşoğlu Seyithan , Tutar Halit , Özdemir Selim
Published: July 2018

Bu araştırma, Bingöl ili ekolojik
koşullarında yetiştirilecek burçak genotiplerinin tohum verimi ve kalite
özelliklerinin belirlenmesi amacıyla 2014 ve 2015 yıllarının yetiştirme
sezonunda yürütülmüştür. Araştırmada, 14 adet burçak genotipi [ICARDA orjinli 6
adet, Diyarbakır ve Mardin popülasyonuna ait 3 adet ve Ankara Üniversitesi
Ziraat Fakültesi’ne ait 5 adet hat] bitki materyali olarak kullanılmıştır.
Araştırma tesadüf blokları deneme desenine göre üç tekrarlamalı olarak
kurulmuştur. Araştırmada; tohum verimi, kes verimi, bin tane ağırlığı, ham kül
oranı, ham protein oranı, ham protein verimi, ADF ve NDF ile ilgili veriler
incelenmiştir. Araştırma sonucunda; genotiplerin tohum verimi 50.3-82.6 kg/da, kes
verimi 354.3-535.9 kg/da, bin tane ağırlığı 32.4-46.6 g, ham protein oranı
%5.8-9.5, ham protein verimi 20.6-39.5 kg/da, ham kül oranı %8.8-13.0, ADF
oranı %35.7-39.8 ve NDF oranı %43.9-50.0 arasında değişim göstermiştir. Bu
sonuçlara göre Bingöl ve benzeri ekolojik koşullarda tohum verimi için 6 ve 13 nolu genotip, kes verimi
için 5 ve 6 nolu genotip, yüksek ham protein verimi için 6 ve 10 nolu genotip,
düşük ADF ve NDF oranı için 1 nolu genotiplerin ekilmesi tavsiye edilmektedir.
Hubungan Pengetahuan Tentang Menstruasi Dengan Sikap dalam Penatalaksanaan Dismenore Primer pada Remaja Putri di SMAN 58 Jakarta
Authors: Wijayanti Anggita , DJ Refirman , Rahayu Sri
Published: July 2018

Primary dysmenorrhea was experienced by about 72.89 % of young women in Indonesia. Primary dysmenorrhea is a common problem that often reported during their cycle.  In other study, there are about 41.2 % of young woman that choose to do nothing in order to reduce their pain.  Therefore, knowledge about menstruation has big part for their attitude and practices to reduce and stop the pain caused by dysmenorrhea. This study aims to know the correlation between menstruation knowledge with attitude in the primary dysmenorrhea management. This study was done in November 2016 at SMAN 58 Jakarta, using descriptive method and correlation study survey technique. All of the class XII female student were used as the population, and 90 responden were taken using simple random sampling. The test showed that the data was homogen and have normal distribution. The regression model Y = 30.557 + 2.166X was significant and showed a linear correlation.  Correlation coefficient obtained from hypothesis test was 0.762. This result showed a strong and positive correlation between knowledge and attitude about primary dysmenorrhea in female student at SMAN 58 Jakarta
Perbandingan Hasil Belajar Biologi Dengan Menggunakan Model Pembelajaran Kooperatif Script daN Model Pembelajaran Konvensional pada Pokok Bahasan Sistem Eskresi di Kelas VIII SMP Muhammadiyah 11 Tello Makassar
Authors: Putra Nurdin Muh.  Putra N Rizaldi Trias Jaya
Published: July 2018

In the world of education, improving the quality of learning both in the mastery of materials and learning methods are always strived. One of the efforts that teachers do in improving the quality of teachers is the preparation of various scenarios of learning activities in the classroom. This study aims to determine the comparison of biological learning outcomes by using cooperative learning model script and conventional learning model. This research was conducted at SMP Muhammadiyah 11 Tello Makassar in March until April 2016. The research method used was a Quasy Eksperiment. The research instrument used is the learning result instrument and tested through t-test statistic. The results obtained that t-count value for post-test data in the experimental class of 3.81 while t-table at the level of significance level α 5%, then the value of α designated in table t is 2.00, so obtained t count ≥ t table (3.81 ≥ 2.00 ). This study suggested that cooperative learning scripts can improve students learning outcomes. 

Keywords: Cooperative Learning script, Conventional Learning, Learning outcomes
Pengaruh Polutan Terhadap Struktur Morfologi Stomata Daun Trembesi (Samanea saman (Jacg) Merr)
Authors: Kusumo Pratiwi Dyah
Published: July 2018

Trembesi (Samanea saman) is one of the plants that is currently developed as one of the green line plants. Stomata as part of the leaf that has the ability to bind air, especially oxygen and carbon dioxide, is one part of the plant that can be used as an indicator to see the effect of pollutants contained in the air. The result was obtained by using an electron microscope to analyze the morphological structure of stomata leaves Trembesi (Samanea saman). Location was determined by two groups, the control group was at the UKI campus environment which was away from air pollution and the treatment group was in the Cawang police station where many vehicles passed through. Within a 90 days after treatment of pollutant exposure to plants, the structure of Trembesi leaf stomata was observed using an electron microscope. Based on the observation, the leaf position in the middle of the tree and the position of the leaf at the bottom of the tree, it was found that the leaves placed in the control position had a finer stomata mouth structure, more leaf hairs, and a wider diameter. While on the leaves that are placed on the location exposed to pollutants, has an irregular leaf mouth structure, fewer leaf feathers, and smaller diameter. This study can be concluded that there was an effect of exposure of pollutant that could change morphology of stomata leaves of Trembesi (Samanea saman).
Penerapan Metode Course Review Horay Untuk Meningkatkan Minat Belajar Mahasiswa Prodi Pendidikan Biologi Universitas Bengkulu
Authors: Anggraini Nike
Published: July 2018

The Purpose of this study is to determine the use of Course Review Horay method for increasing students interest in Vertebrate Zoology courses in Biology Education Department year 2017/2018. This study is a Classroom Action Research, the subjects consisted of 47 students. Data were collected using observation, questionnaires, and documentation. Data obtained were analyzed using descriptive analysis and effect size. This study was conducted in three cycles, each consisting of one meeting during 2 x 50 minutes. Result showed that the Course review horay method could increase students’ interest and the cognitive learning outcomes.  Based on questionnaires on students learning interest, at cycle I, data obtained as much as 44,73%, while at cycle II showed an increase in average score by 81,58%. As for the cognitive learning outcomes showed an increase in post-test value in each cycle. The effect size between cycle I and cycle II as much as 0.39 representing small effect size. While the effect size for cycle II and III were 1, 78 which represent high effect size.
Analisis Distribusi Serangga Tanah Jalan MT Haryono dan Tlogomas Malang
Authors: Zayadi Hasan , Mubarakati Nurul Jadid
Published: July 2018

Vegetation in urban areas can be viewed, as compensation for environmental change due to urbanization of plant diversity affecting the diversity of animals in an ecosystem, the loss of plant species will disrupt the food webs in the ecosystem. Research on the diversity of soil insects found in shade trees species is still not widely done. The purpose of this study were to identify the types of soil insects found in shade trees along Dinoyo and Tlogomas roadside in sub-district of Lowokwaru, Malang and to characterize spatial distribution of soil insect species found in shade trees along Dinoyo and Tlogomas roadside in sub-district of Lowokwaru Malang by using GIS application. Sampling was conducted at two different locations (MT Haryono and Tlogomas Road). Soil insect analysis was calculated using Shannon-Wiener (H') index at different sites. Variables measured were Relative Frequency (FR) and Relative Abundance (KR), while mapping Spatial descriptions. Distribution of soil insects was done by stages in spatial data analysis including digitization, attribute data, map overlay, and map output results. The results of this study obtained the number of species of soil insects as many as 14 species with a total of 287 individuals. Soil insects most commonly found were family Formicidae, the species of Momorium destructor with the number of individuals as much as 87 individuals, and Paratrechina longicornis as many as 86 individuals.
Efektifitas Pemberian Suplemen Serbuk Kunyit (Currcuma longa L.) Terhadap Jumlah Bakal Telur (Hierarki Folikel) Puyuh Jepang (Coturnix-coturnix japonica L)
Authors: Putra Sukarman Hadi Jaya
Published: July 2018

The purpose of this research was to study the effect of turmeric powder supplementation prior to sexual maturity of Japanese quail’s egg. Forty-five of female quils were assigned into completely randomized design with 3 treatments (P0: without tumeric powder or control, P1: level of turmeric powder 54 mg/quail/day, P2: level of turmeric powder 108 mg/quail/day) and each treatments used 3 quils with 5 replications respectively. The treatments were administrated every day for 30 days started at the age of 14 days. Parameters measured were number of follicles hierarchy. Statistical analysis used ANOVA followed by Duncan’s test. The result showed that administrated turmeric powder suplementation at level 108 mg/quail/day had significantly increase the number of Japanese quail follicles hierarchy prior to sexual maturity.
Factors Affecting the Level of Hemoglobin on Junior High School Children on Coast Regional District of North Lombok
Authors: Nurdiana Nurdiana
Published: July 2018

Hemoglobin is the number of hemoglobin ain red blood cells that assessed in grams per decilitre. One of the problems in the hemoglobin is anemia. The prevalence of anemia in junior high school students aged 10-14 years old at 57.1%. anemia is caused by a decrease in hemoglobin levels. These levels can change at any time depending on various factors, especially in junior high school students who are still in its infancy. Therefore, the researchers wanted to know what are the factors that effect hemoglobin levels were in junior high school students in Nort Lombok region. The sampling technique was aconsecutive sampling, which any student who meets the study inclusion an exclusion criteria included in the study until acertain time, so that the required number of students are met. Data retrieval was done by using research instruments such as questionnaires, complete blood count, and anthropometric examination. Statistical analysis using descriptive analysis, bivariate analysis using spearmans, and multivariate analysis using linear regression to test the strength of each risk factor. The results showed there was one factor that effects the hemoglobin level in junior high school students on coast regional district of Nort Lombok. This factor was diet.
Identifikasi Fauna Tanah Pada Areal Pascapenambangan Tanah Urugan sebagai Reklamasi Lahan Pertanian di Desa Lendang Nangka Provinsi Nusa Tenggara Barat
Authors: Sazali Munawir
Published: July 2018

Keberadaan mesofauna dan makrofauna tanah bisa dijadikan sebagai bioindikator kesuburan tanah. Keanekaragaman fauna tanah sangat ditentukan oleh sumber nutrisi berupa biomassa yang tersedia untuk keberlangsungan hidup. Tujuan dari penelitian ini untuk mengidentifikasi keanekaragaman spesies dari makrofauna dan mesofauna tanah serta hubungannya dengan faktor lingkungan (environment faktors) pasca penambangan tanah urugan di Desa Lendang Nangka. Manfaat penelitian ini untuk menyediakan informasi dan merekomendasikan langkah monitoring keberadaan mesofauna dan makrofauna tanah sebagai bioindikator kesuburan tanah, sehingga aktifitas reklamasi tanah pasca tambang sesuai dengan keinginan masyarakat. Hasil analisis data kekayaan jenis (R1) dan keanekaragaman (H’) pada masingmasing lokasi memiliki perbedaan, hal ini sangat dipengaruhi oleh lama waktu pasca tambang dan faktor fisika dan kimia tanah. H’ pada Lokasi I (Dusun Lendang Bagek/ tiga tahun pasca tambang) = 1,35<1,5, menunjukkan diversitas fauna tanah yang rendah. Lokasi II (Desa Lendang Nangka Utara/ 9 tahun pasca tambang) dengan H’=2,01<3,5 menunjukkan diversitas sedang dan kekayaan spesies yang tinggi.