bluuebunny/crossref_metadata_2025 huggingface dataset:
Intramolecular Oxidative Coupling between Unactivated Aliphatic C-H and Aryl C-H Bonds
Authors: Liao Yang , Zhou Yi , Zhang Zhen , Fan Junzhen , Liu Feng , Shi Zhangjie
Published: December 2020

Direct oxidative coupling of different inert C-H bonds is the most straightforward and environmentally benign method to construct C-C bonds. In this article, we developed a Pd-catalyzed intramolecular oxidative coupling between unactivated aliphatic and aryl C-H bonds. This chemistry showed great potential to build up fused cyclic scaffolds from linear substrates through oxidative couplings. Privileged chromane and tetralin scaffolds were constructed from readily available linear starting materials in the absence of any organohalides and organometallic partners.
Improved Sampling Strategies for Protein Model Refinement based on Molecular Dynamics Simulation
Authors: Heo Lim , Arbour Collin , Feig Michael
Published: December 2020

Protein structures provide valuable information for understanding biological processes. Protein structures can be determined by experimental methods such as X-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy, or cryogenic electron microscopy. As an alternative, in silico methods can be used to predict protein structures. Those methods utilize protein structure databases for structure prediction via template-based modeling or for training machine-learning models to generate predictions. Structure prediction for proteins distant from proteins with known structures often results in lower accuracy with respect to the true physiological structures. Physics-based protein model refinement methods can be applied to improve model accuracy in the predicted models. Refinement methods rely on conformational sampling around the predicted structures, and if structures closer to the native states are sampled, improvements in the model quality become possible. Molecular dynamics simulations have been especially successful for improving model qualities but although consistent refinement can be achieved, the improvements in model qualities are still moderate. To extend the refinement performance of a simulation-based protocol, we explored new schemes that focus on an optimized use of biasing functions and the application of increased simulation temperatures. In addition, we tested the use of alternative initial models so that the simulations can explore conformational space more broadly. Based on the insight of this analysis we are proposing a new refinement protocol that significantly outperformed previous state-of-the-art molecular dynamics simulation-based protocols in the benchmark tests described here.
Ultrasmall Manganese Ferrites as Multimodal Bioimaging Agents and Fenton/Haber-Weiss Catalysts
Authors: Carregal-Romero Susana , Miguel-Coello Ana Beatriz , Martínez-Parra Lydia , Fernández-Afonso Yilian , Plaza Sandra , Gutierrez Lucia , Lecante Pierre , Blasco-Iturri Zuriñe , Fadón Lucía , Almansa-García Ana C. , Carrillo-Romero Juliana , Möller Marco , Otaegui Dorleta , Groult Hugo , Ruiz-Cabello Jesús
Published: December 2020

Ultrasmall manganese ferrite nanoparticles display interesting features in bioimaging and Fenton nanocatalysis. However, little is known about how to optimize these nanoparticles to achieve simultaneously the highest efficiency in both types of applications. Herein, we present a cost-efficient synthetic microwave method that enables manganese ferrite nanoparticles to be produced with excellent control in size, chemical composition and colloidal stability. We show how the reaction’s pH has a substantial impact on the Mn incorporation into the nanoparticles and the level of Mn doping can be finely tailored to a wide range (MnxFe3-xO4, 0.1 ≤ x ≤ 2.4). The magnetic relaxivities (1.6 ≤ r1 ≤ 10.6 mM-1s-1 and (7.5 ≤ r2 ≤ 29.9 mM-1s-1) and Fenton/Haber-Weiss catalytic properties measured for the differently doped nanoparticles show a strong dependence on the Mn content and, interestingly, on the synthetic reaction’s pH. Positive contrast in magnetic resonance imaging is favored by low Mn contents, while dual mode magnetic resonance imaging contrast and catalytic activity increases in nanoparticles with a high degree of Mn doping. We show that this is valid in solution, in a murine model and intracellularly respectively. Besides, this synthetic protocol allows core-radiolabeling for high-sensitive molecular imaging while maintaining relaxometric and catalytic properties. All of these results show the robust characteristics of these multifunctional manganese ferrite nanoparticles as theranostic agents.
A Bio-Inspired Lanthanum-Ortho Quinone Catalyst for Aerobic Oxidation of Alcohol
Authors: Zhang Ruipu , Zhang Long , Zhang Ming-Tian , Luo Sanzhong
Published: December 2020

Oxidation reactions are fundamental transformations in organic synthesis and chemical industry. With oxygen or air as terminal oxidant, aerobic oxidation catalysis provides the most sustainable and economic oxidation processes. Most aerobic oxidation catalysis employs redox metal as its active center. While nature provides non-redox metal strategy as in pyrroloquinoline quinone (PQQ)-dependent methanol dehydrogenases (MDH), such an effective chemical version is unknown. Inspired by the recently discovered rare earth metal-dependent enzyme Ln-MDH, here we show that an open-shell semi-quinone anionic radical species in complexing with lanthanum could serve as a very efficient aerobic oxidation catalyst under ambient conditions. In this catalyst, the lanthanum metal serves only as a Lewis acid promoter and the redox process occurs exclusively on the semiquinone ligand. The catalysis is initiated by 1e--reduction of lanthanum-activated ortho-quinone to a semiquinone-lanthanum complex La(SQ-.)2, which undergoes a coupled O-H/C-H dehydrogenation for aerobic oxidation of alcohols with up to 330 h-1 TOF. This study suggests a possible functional mode of semiquinone radicals, widely observed with quinoproteins in Nature. Moreover, this unique reductive activation strategy as well as the resulted radical anion as redox ligand creates a new turning point in the development of efficient aerobic oxidation catalysis.
Modern perspectives in sequential therapy for metastatic colorectal cancer with reference to the use of regorafenib
Authors: Sekacheva M. I. , Nuriev R. I. , Rozhkov A. A. , Semenkov A. V. , Bagmet N. N. , Boroda A. M.
Published: December 2020

Over the past two decades, many new variants of targeted therapy for metastatic colorectal cancer (mCRC) had appeared, and significantly increased patient survival. However, there were questions relating to the definition of the optimal sequence and the combination of different drugs. Cytotoxic agents, including irinotecan, oxaliplatin, 5-fluorouracil and capecitabine, are the basis of the treatment of mCRC. In addition, the arsenal of modern oncologist includes the group of drugs inhibiting the epidermal growth factors (for example, cetuximab and panitumumab) and inhibiting tumor angiogenesis factors (for example, bevacizumab and aflibercept). Moreover, the use of immuno-oncology drugs, trastuzumab or encorafenib is possible in case of knowing tumor-specific molecular signature. Unfortunately, these new indications can be used only in small proportion of patients. The multikinase inhibitor regorafenib takes a special place, it can be used in patients in spite of RAS mutation status. The increasing attention has been paid to the selection of the drugs for sequential therapy of mCRC, recently. This review discusses important clinical data on the direct role of targeted drugs in the treatment of mCRC in different subgroups of patients.
Use of nivolumab for colon cancer with Lynch syndrome
Authors: Khakimov G. A. , Tryakin A. A. , Khakimova G. G.
Published: December 2020

Lynch syndrome (LS), which occurs as a result of the defects in DNA mismatch repair, is characterized by an increased risk of colon, endometrial and urinary tract cancers. It is known that in case of colorectal cancer, the presence of high-frequency microsatellite instability (MSI-H) is associated with better survival rates, independent of other prognostic factors, including the stage of tumor development. Thus, in stage II sporadic colorectal cancer, MSI-H occurs in 22% of cases, in stage III in 12% of cases, and in stage IV only in 2% of cases. Regardless of the type of the tumor, immunotherapy using checkpoint inhibitors has been approved for treating patients with unresectable or metastatic tumors with deficient DNA mismatch repair (dMMR), this fact can be used as an approach to treatment patients with LS. The article describes the clinical observation of the patient with germline mutation in MLH1 gene, suffering from multiple primary malignancies of the colon, who has been receiving nivolumab for 26 months. This observation demonstrates the success of immunotherapy after sixth-line chemotherapy, showing the potential control of tumor growth in patients with LS.
Lenvatinib as the key component of first-line therapy for patients with unresectable hepatocellular carcinoma
Authors: Bolotina L. V.
Published: December 2020

Throughout the last 10 years, liver cancer mortality rate in the Russian Federation consistently exceeded the morbidity rate, which is related to the complexity of early diagnostics, absence of effective screening and oncological alertness of allied-profession doctors. In the situation when late disease intelligence does not frequently allow radical treatment, palliative methods remain the only option of survivability enhancement and improving the patients quality of life. Lenvatinib was approved as the first-line drug in the treatment of unresectable hepatocellular carcinoma based on the data of the REFLECT trial, in which the drug demonstrated achieving the patients overall survival (OS) comparable to the activity of sorafenib (13.6 months for lenvatinib vs 12.3 months for sorafenib; hazard ratio HR 0.92; 95% confidence interval CI 0.791.06). At the same time, significant inferiority of lenvatinib was observed for secondary endpoints: progression-free survival PFS (7.4 months for lenvatinib vs 3.7 months for sorafenib; HR 0.66; 95% CI 0.570.77;р0.0001), time to progression (8.9 months for lenvatinib vs 3.7 months for sorafenib; HR 0.63; 95% CI 0.530.73;р0.0001) and objective response rate ORR (24.1% for lenvatinib vs 9.2% for sorafenib). The further analysis of the results of the REFLECT study revealed the additional factors impacting patients survival, such as the level of a-fetoprotein (AFP) before treatment, treatment ORR, performance of subsequent antitumor therapy and procedures after completion of the target first-line therapy. In patients responding to lenvatinib in the first line and further receiving any second-line therapy, the mOS was 25.7 months as compared with the median overall survival (mOS) of 22.3 months in patients responding to sorafenib and receiving further second-line therapy. Additionally, in responders switching from lenvatinib to sorafenib, the mOS was 26.2 months. In the recently published comparative study of lenvatinib and transarterial chemoembolization on the BCLC B stage, inferiority of lenvatinib was demonstrated in terms of OS, PFS and ORR in certain patient categories. Considering the data obtained in the REFLECT population, where in patients achieving the RR to the first-line treatment with lenvatinib and further receiving the local antitumor procedures the mOS increased to 27.2 months (95% CI 20.729.8), prescribing target and locoregional therapy in certain cases in this very sequence is possible. The recently published data about administration of lenvatinib outside of the inclusion criteria for the REFLECT trial, have proved the efficacy and safety of this drug administration in real clinical practice, thus significantly expanding our understanding of the key role of lenvatinib in the first-line treatment of unresectable hepatocellular carcinoma.
Chronic lymphocytic leukemia/small lymphocytic lymphoma
Authors: Nikitin E. A. , Bialik T. E. , Zaritskii A. Iu. , Iseber L. , Kaplanov K. D. , Lopatkina T. N. , Lugovskaia S. A. , Mukhortova O. V. , Osmanov E. A. , Poddubnaya I. V. , Samoilova O. S. , Stadnik E. A. , Falaleeva N. A. , Baikov V. V. , Kovrigina A. M. , Nevol’skikh A. A. , Ivanov S. A. , Khailova Zh. V. , Gevorkian T. G.
Published: December 2020

Chronic lymphocytic leukemia/small lymphocytic lymphoma. Clinical recommendations
PHYSICOCHEMICAL PROPERTIES OF QUATERNARY SALTS OF ETHYL ETHER 4-MORPHOLINYL ACETIC ACID
Authors: Белоцерковец Нина Ивановна
Published: December 2020

Для четвертичных солей Х-алкил-Х-(этоксикарбонил)-метилморфолиния (алкил: бензил-, додецил-, гексадецил-) получены изотермы поверхностного натяжения на границе водный раствор-воздух, определены значения критической концентрации мицеллообразования, предельной адсорбции, площади молекулы в насыщенном адсорбционном слое.

For the quaternary salts of N-alkyl-N-(ethoxycarbonyl)methylmorpholinium (alkyl: benzyl-, dodecyl-, hexadecyl-), surface tension isotherms were obtained at the water-air interface, values of critical micelle concentration, limiting adsorption, and the area of the molecule in saturated adsorption layer were determined.
STIMULATING ACTION OF BORON-CONTAINING CHELATIC COMPLEXES ON LONG-FLAX
Authors: Петрова Алла Анатольевна , Смирнова Татьяна Ивановна , Павлов Максим Николаевич , Варламова Анна Александровна , Никольский Виктор Михайлович
Published: December 2020

На растениях льна-долгунца в условиях полевого опыта исследовано биостимулирующее действие борат-иминодисукцината (В-ИДЯК) и борат-этилендиаминдисукцината (В-ЭДДЯК) в сравнении с борной кислотой и борат-этилендиаминтетраацетатом (В-ЭДТУК). Обнаружено, что наиболее активным биостимулятором является В-ЭДДЯК. Обработка растений льна раствором В-ЭДДЯК увеличивает не только урожайность льносоломы и семян, но и улучшает физико-химические свойства льноволокна.

The biostimulating effect of borate-iminodisuccinate (B-IDAC) and borate-ethylenediamine disuccinate (B-EDDJAC) was studied on long-flax plants under field conditions in comparison with boric acid and borate-ethylenediaminetetraacetate (B-EDTA). It was found that the most active biostimulant is B-EDDYAK. Processing flax plants with V-EDDJAC solution not only increases the yield of flax straw and seeds, but also improves the physicochemical properties of flax fiber.
MEDIDAS DE BIOSEGURIDAD EN ADMINISTRACIÓN DE MEDICAMENTOS POR ENFERMERAS DE CIRUGÍA MEDICINA EMERGENCIA DEL HOSPITAL REGIONAL DOCENTE LAS MERCEDES CHICLAYO 2019
Authors: Bravo Castañeda Evelyn Vanessa
Published: December 2020

Esta investigación tuvo como objetivo determinar la práctica de las medidas de bioseguridad en la administración de medicamentos por el personal de enfermería del Hospital Regional Docente Las Mercedes - 2019. Para analizar la situación se aplicó una metodología del tipo no experimental, descriptivo, teniendo la perspectiva cuantitativa. La población estuvo conformada por 83 profesionales de enfermería del Hospital Regional Docente Las Mercedes que cumplieron con los criterios de inclusión. El instrumento que se utilizó para esta investigación fue una encuesta validada por 3 expertos especialistas. Se obtuvo como resultado que un 98.8% de profesionales de enfermería se encuentran expuesto a sufrir algún accidente con material contaminado y estar en riesgo de contraer alguna infección por no utilizar de manera adecuada las medidas de bioseguridad.
大黑汀水利枢纽金属结构的防腐蚀保护
Authors: 员 会超
Published: December 2020

论文针对大黑汀水利枢纽金属结构的运行环境，给出了适宜的防腐蚀保护措施。同时，对涂料防腐工艺和金属喷镀工艺进行了分析比较，指出对水下金属结构来说，采用金属喷镀加涂料封闭的防腐蚀保护工艺是合理的。
The COVID-19 Pandemic and Pacific resilience
Authors: Ekeroma Alec
Published: December 2020

On the 21st November 2020, the number of COVID19 cases recorded worldwide is about to reach 59 million with close to 1.4 million deaths.1 Countries such as New Zealand with the promptness in strict border controls, screening, tracking and isolation policies and procedures have the least rate of infection and deaths, compared to countries such as the United States of America (USA) who lacked a prompt coordinated response, leadership and population willingness to prevent infection spread.
Evaluating the feasibility and effectiveness of self-monitoring of health among Samoan women: a randomized trial
Authors: Kocher Erica , Desai Mayur , Rivara Anna , Naseri Take , Hawley Nicola
Published: December 2020

Objective: Self-monitoring technologies that help individuals track their health have proven effective in high-income countries but have not been widely tested or marketed in the Pacific islands. We conducted a pilot randomized controlled trial in Samoa to investigate the feasibility and acceptability of step-counters and digital scales.

Methods: The trial enrolled 44 Samoan women (31-40 years), without previously diagnosed chronic conditions (hypertension, diabetes, etc.), who reported motivation to become more physically active. After measuring daily step counts for one week in the absence of feedback, participants were randomly assigned to one of three groups for a four-week intervention period: 1) FitBit Zip® step-counter, 2) digital BodyTrace© scale, or 3) both devices. Outcomes of interest were device use, psychosocial indicators of health, daily step counts, and body mass index, measured at baseline and post-intervention.

Results: Participants who received scales used them a median of 5.5 times during the four-week intervention period. While FitBits were used a majority of days during the baseline period, there was significant decline in use during the intervention. In all groups, Health Locus of Control, Self-Efficacy for Exercise, and Weight Efficacy improved. However, while the Scale Only group reported improved health-related quality of life, the two groups that used FitBits either did not significantly change or significantly decreased in their assessments of this measure. No group demonstrated change in average daily step counts during the intervention; BMI increased among the two groups using the scales.

Conclusions: Results suggest that self-monitoring technologies are acceptable in Samoa and generally improve psychosocial indicators of health. Further research is necessary to assess their effectiveness as an intervention tool and to determine how best to sustain device use over time. The significant increase in BMI over the relatively short intervention period highlights the importance of developing effective intervention approaches in this setting.
Developing a child health survey for a Pacific Island nation. Integrating the Delphi method with Pacific methodologies
Authors: Langridge Fiona , 'Ofanoa Malakai , Fakakovikaetau Toakase , Percival Teuila , Wilkinson-Meyers Laura , Grant Cameron
Published: December 2020

Introduction: There is minimal information available that describes the health of children of primary school age (5-12 years) living in the Pacific. Current tools that exist for measurement of health have not been developed with Pacific paradigms in mind. Our objective was to describe the development of a culturally and contextually appropriate health survey to enable measurement of the health status of 5-12 year olds living in a Pacific Island Nation.
Methods: Integrating a Delphi method with Pacific methodologies, two rounds of online questionnaires involving 33 panel members reviewed what to include in a health survey for primary school-aged children living in Tonga. The panel consisted of paediatric clinicians and academics, teachers and parents from Tonga, New Zealand, USA, and the UK.
Results: Panel consensus was met on a range of domains to be included in the survey including: general demographics (80%), environment (80%), resilience and risk (88%), household economics (80%), psychological functioning (92%), social functioning (92%), physical functioning (88%), cognitive functioning (92%) and individual health conditions (84%). Particular importance was placed on including questions that described exposure of children to violence and abuse (93%).
Conclusions: Based upon the consensus of a diverse expert panel, the domains that are necessary for the measurement of health in primary school-aged children living in Tonga were identified. The Delphi method proved a valid and useful technique to assist with the development of such a health survey and enabled the incorporation of a Pacific lens – a Tongan understanding of measuring children’s health.
Региональное регулирование процессов организации и оценки эффективности деятельности органов местного самоуправления (на примере Краснодарского края)
Authors: Коркишко Инна Вячеславовна
Published: December 2020

Целью исследований является определение качества социологических опросов населения Краснодарского края в рамках оценки эффективности деятельности органов местного самоуправления. Методы. В статье проводится анализ процесса организации опросов населения в системе оценивания эффективности деятельности органов местного самоуправления по реализации социально-экономической политики в Краснодарском крае. Исследования осуществлялись с применением методов обобщения, классификации и сравнительного анализа, а также статистических и графических методов обработки информации. В результате исследований выявлены и систематизированы недостатки организации опросов. Область применения результатов. Результаты проведенного анализа могут применяться государственными органами исполнительной власти для усовершенствования методики оценивания качества деятельности муниципальной власти. Выводы. В целях повышения качества оценки эффективности деятельности муниципальных властей процедура проведения социологических опросов и опубликования их результатов должна совершенствоваться.
Development of SETS E-Module Integrated with POE Model for Science Learning
Authors: Wilujeng Insih , Putri Tri Suci Yolanda
Published: December 2020

This research developed Science, Environment, Technology, Society (SETS) e-module integrated with predict, observe, explain (POE) model on the subject matter of Earth Layer and Its Dynamics for grade VII students. This study aimed to reveal i) the feasibility of the developed e-module for grade VII students, and ii) the practicality of the developed e-module and its dynamics. This is a developmental research adopting the ADDIE model consisting of five stages, i.e.: analysis, design, development, implementation, and evaluation. The subject of the limited test consisted of 15 students of grade VIII.G of Public Junior High School 8 Yogyakarta. The data were collected using a product feasibility assessment sheet for material and media experts, a product practicality assessment sheet for teachers, and a product readability assessment sheet for students. The results show that the developed e-module was feasible to be used according to the material and media experts and the developed e-module is practical according to teachers and students.
DIGITAL SKILLS DEVELOPMENT AND ICT TOOLS FOR FINAL QUALIFICATION ASSESSMENT: SURVEY STUDY FOR STUDENTS AND STAFF OF EUROPEAN AND ORIENTAL PHILOLOGY PROGRAMS
Authors: Makhachashvili Rusudan , Semenist Ivan , Bakhtina Anna
Published: December 2020

The global pandemic and subsequent quarantine measures and restrictions have posed an array of challenges to the structure and procedure of university summative assessment process. Qualification assessment for Foreign Languages major programs in particular is a strict regimen process that involves different stages (oral and written exams, final project viva, internal and external review). Factors of societal change, that provide the backdrop for skillset critical transformation, crucial for the COVID-19 emergency educational framework are considered. The study premise is based on identification of various competency principles, derivative of 21st century skills for university staff members and projected digital literacy requirements. A correspondence between 21st century skills framework, Competences 2020 framework and the newly devised Global Skills framework has been devised. The study objective is to critically review the applied case and best practices of Borys Grinchenko Kyiv University Digital Final Qualification Assessment for students of European (French, Italian, Spanish, English, German) and Oriental (Mandarin Chinese, Japanese) Languages major programs, employed in the year 2020 due to quarantine measures. The survey and analysis of different ICT tools is used to translate real life qualification assessment practices into online blended format. The investigation also seeks to identify various groups of applied digital skills and collaboration skills, utilized through qualification assessment process by all parties (students, faculty and referees). It is determined how in the situation of the COVID-19 pandemic lockdown all elements of the Final Qualification Assessment at Borys Grinchenko Kyiv University for European and Oriental Languages programs have been relegated to the digital, remote or blended format with the use of ICT tools. The qualification assessment regimen for foreign languages major programs was adapted to digital format as a framework (a legal procedure that results in the degree confirmation of a student), the string of consecutive communicative activities according to the legal procedure, the "ritual" scenario. Comparative results of the Final Qualification Assessment digital format adaptation for different groups of foreign languages programs (European and Oriental) are devised
THE INSTRUCTIONAL PRACTICES OF SECONDARY SCHOOL TEACHERS IN ETHIOPIA: HULET EJU ENESIE WOREDA
Authors: ZEKIROS BIZU KINFE
Published: December 2020

This study was examined secondary school teachers’ instructional practices by using First Principle of Instruction model as guiding principle. Both qualitative and quantitative methods were employed. The total populations of the study were 52. From these 40 Biology teachers, 4 directors, 4 supervisors and 4 department heads were selected through comprehensive sampling technique. Data were obtained through questionnaire, interview, classroom observation and document analysis. Various statistical tools such as mean, frequency and percentage were applied to analyze the data. The finding indicated that secondary school Biology teachers design their lessons by using First Principle of Instruction Model and they practiced it partially. And biology teacher’s instructional practices are aligned partially with First Principle of Instructional Model. Some factors that affect the design and implementation of the lessons based on the First Principle of Instruction model were identified: teachers’ related problems, students related problems, time constraints, policy issues, and resources. Based on the finding, it is recommended that woreda education office and general secondary schools should have to prepare short- and long-term training, seminars and workshop for teachers. Secondary school directors and supervisors should help teachers to have personal, professional knowledge and pedagogical skill. They should also support them by creating good educational environment.
TWO STAGE ON OFF KEYING CLASS A RF POWER AMPLIFIER IN 0.18μm CMOS TECHNOLOGY
Authors: Senadeera P.M. , Xie Zhijian , Dogan Numan S.
Published: December 2020

A novel architecture for the On Off Keying (OOK) modulator with high gain and high data rate power amplifier (PA) operating at 11.6 GHz IBM 0.18-µm RF CMOS technology is presented for a X-band passive RFID tag. Currently used low frequency switching techniques such as multiplexers were not functioning in the high frequency X-band architectures. In this novel approach OOK modulator with power amplifier, a CMOS switch was used to transmit ‘1’ and ‘0’ coming from the digital signal unlike in the existing low frequency architectures. Both the load and driver in this proposed PA were class A operation supplied by a single ended 1.83V source. The important design considerations include output power, 1 dB compression point and linearity. The fabricated results of the amplifier have a 1 dB compression point of 1.2 dBm and input power of 5.19 dBm at 9.2 GHz.
Os reflexos do ensino remoto na docência em tempos de pandemia da Covid-19
Authors: Pereira Castro Douglas , Danielle de Sousa Rodrigues Nayane , Rogério Vargas Ustra Sandro
Published: December 2020

A pandemia da Covid-19 impactou o campo educacional e os reflexos foram percebidos imediatamente devido à necessidade do isolamento social e a suspensão das aulas presenciais. A pesquisa justifica-se pela necessidade de compreender os reflexos das aulas remotas nas práticas pedagógicas de professores. Objetivou-se caracterizar os reflexos da educação remota nas práticas pedagógicas de professores duas instituições de ensino privadas. A pesquisa teve caráter qualitativo e exploratório, com amostra de 57 professores (35 mulheres e 22 homens) de duas instituições privadas de um município de Minas Gerais. Utilizou-se um questionário como instrumento de coleta de dados. Os resultados indicaram que o trabalho docente aumentou durante as aulas remotas e que houve apoio da instituição na transição. A maior parte dos professores não apresentou dificuldades em relação às ferramentas para aulas remotas, entretanto disseram precisar com maior recorrência de auxílio nas questões tecnológicas. Os professores consideraram a dimensão socioafetiva como a mais prejudicada pelo ensino remoto. Concluiu-se que o ensino remoto abalou as estruturas do ensino e promoveu uma inquietação significativa dos docentes em relação às metodologias e as novas tecnologias no ambiente de aula.
Penerapan Multirepresentasi Pada Pembelajaran Inkuiri Terbimbing Terhadap Penguasaan Konsep Dari Gaya Belajar
Authors: Safitri Indah , Kaniawati Ida , Rusnayati Heni
Published: December 2020

This study aims to determine the increase in mastery of the concept of high school students after the implementation of a multi-representation approach to guided inquiry learning that has been adapted to student learning styles on Work material. The research method used was quasi experimental using one group pre-test post-test design. The research sample was students of class X MIPA 6 at one school in SMA Negeri in Bandung, totaling 36 students. The research instrument used was a test of mastery of the concept, a VARK learning style questionnaire, a student response questionnaire, and an observation sheet. Based on the findings of the paired t-test, the absolute value of t is 21.16 and t-table is 2.03, so H0 is rejected and Ha is accepted. The results of this research, there is a significant influence on the application of multi-representation approaches to guided inquiry learning that is adapted to studentÃ¢â¬â¢s VARK learning styles. Also seen the overall gain test results obtained a gain value of 0.561 in the medium category. The gain value obtained by students with kinesthetic learning style is greater than students who have visual, aural, read/write, and multimodal learning style, with a value of 0.584 in medium category. And the study group that gets the greatest gain is the learning group two and the learning group three with the gain value 0.612 with the medium category.
Autorregulación del aprendizaje, estrés escolar y rendimiento académico
Authors: Valiente-Barroso Carlos , Suárez-Riveiro José Manuel , Martínez-Vicente Marta
Published: December 2020

El aprendizaje autorregulado implica un proceso complejo que engloba aspectos cognitivos y motivacionales interrelacionados para conseguir el éxito escolar y cuyas carencias pueden originar estresores cotidianos en la escuela. En este estudio se pretende comprobar si existen diferencias en el uso de estrategias autorreguladoras del aprendizaje según distintos niveles de estrés escolar y de rendimiento académico. Participaron 620 estudiantes de 5º y 6º de primaria con edades comprendidas entre 10 y 12 años (M = 10.35; DT = 0.63) en un estudio transversal, de metodología no experimental, descriptivo, correlacional e inferencial multivariado. Los resultados indican diferencias significativas en estrategias de apoyo, estrategias complementarias al aprendizaje, actitud hacia el estudio y autoconcepto académico según distintos niveles (bajo, medio y alto) de estrés escolar, siendo además significativas las diferencias entre los estudiantes de menor y mayor rendimiento académico en estrategias complementarias al aprendizaje y en actitud hacia el estudio, variables estas últimas que se evidencian predictoras del estrés escolar. En conclusión, se resalta la necesidad de que las programaciones docentes tengan como referente el desarrollo de la competencia aprender a aprender que sustenta el aprendizaje autorregulado y que además puede actuar como medida preventiva del estrés escolar.
Regresión y remodelado de cámaras cardíacas en el seguimiento tras el implante de prótesis aórticas transcatéter
Authors: Taboada Rubén
Published: December 2020

El reemplazo valvular aórtico transcatéter (TAVR) ha aumentado debido al envejecimiento y riesgo de la población. Algunos estudios han mostrado resultados prometedores sobre su resultado hemodinámico con tasas adecuadas de morbilidad y mortalidad. Sin embargo, se desconoce el impacto de estas bioprótesis sobre la masa ventricular izquierda (LVM). El objetivo principal de nuestro estudio fue analizar la regresión de LVM y el remodelado ventricular con estas bioprótesis en pacientes del mundo real sometidos a recambio valvular aórtico vía transcatéter. Desde enero de 2010 a diciembre de 2011, 61 pacientes fueron sometidos a reemplazo valvular aórtico transcatéter por estenosis aórtica severa. Se recogieron y analizaron las características demográficas, clínicas y los parámetros hemodinámicos, electrocardiográficos y ecocardiográficos. Los resultados son: observamos diferencias estadísticamente significativas pre y postoperatorio en los parámetros electrocardiográficos, expresados por criterios de Sokolow-Lyon, Cornell y productos de duraciónvoltaje; el tamaño del tabique interventricular mostró una disminución de 14 mm a 11 mm y la masa ventricular indexada mostró una disminución de hasta 30 g / m2, es decir, se redujo de 145,5 g / m2 a 115 g / m2. Las conclusiones son: el remodelado ventricular es favorable en los grupos TAVR medidos por ecocardiografía y criterios eléctricos, mejorando la contractilidad y la supervivencia libre de eventos al año de seguimiento.
RETRACTED: Physico-chemical Characteristics of the Soils in Three Church Forest of Central Ethiopia
Authors: Tadesse Kifle Eguale
Published: December 2020

The description of the Retraction: Original article is retracted due to the detected the findings are unreliable, and the result of major error. This decision has been approved by the editor-in-chief and the author. Retraction note DOI: https://doi.org/10.30564/re.v2i4.2368Retraction Date: January 18, 2022
Protective properties in Hymenaea martiana Hayne against multi-drug-resistant Staphylococcus aureus
Authors: Vieira Dielson Da Silva , Da Silva Tânia Maria Sarmento , Hackett Timothy A. , Barros Mariana de , Pires Teixeira Weslen Fabrício , Pereira Diniz Juliana Campos , Gorni Pedro Henrique , Da Costa Sanely Lourenço , Scatamburlo Moreira Maria Aparecida , Da Costa Mateus Matiuzzi , Formiga Feitosa Francisco Leydson
Published: December 2020

Antibiotic resistance represents a widespread problem in milk production. The identification of compounds for a topically applied ointment used in mastitis therapy remains elusive. Compounds from the genus Hymenaea can be administered in cases of multi-drug-resistant Staphylococcus aureus infection for ruminant species, but the protective properties are not well known. Wi this research the aim is verify the protective effects of H. martiana against S. aureus infection in bovine mammary epithelial cell line (MAC-T) and to obtain an antioxidant profile evaluation in vitro. The MAC-T cells were challenged with S. aureus after being exposed to the extract of the H. martiana in the protective assay. For the verification of the viability of the MAC-T cells, the MTT assay was performed, and was used dilutions of the plant extract, starting at 2.5%. The extract of H. martiana was evaluated for antioxidant aspect in different diluition by FRAP, ORAC and DPPH. A variety of flavonoids (quercetin, luteolin, etc.) have been identified as the main components by using mass spectrometry, reinforcing our in vitro findings that flavonoids, especially quercetin, have a medicinal profile capable of killing mastitis-causing bacteria. An excellent antioxidant pattern was observed in the 2.5% solution; however, membrane integrity in MAC-T cells was compromised. Those findings suggest low dilutions of H. martiana extract has a desirable protective effect from S. aureus pathogenesis. Our in vitro studies can be gleaned upon for further in vivo studies.
Dualisme Kewenangan Pengawasan Rancangan Peraturan Daerah oleh Pemerintah Pusat dan Dewan Perwakilan Daerah
Authors: Ginting Eriko Fahri , Wicaksono Dian Agung
Published: December 2020

Undang-Undang Nomor 2 Tahun 2018 tentang Perubahan Kedua Atas Undang-Undang Nomor 17 Tahun 2014 tentang Majelis Permusyawaratan Rakyat, Dewan Perwakilan Rakyat, Dewan Perwakilan Daerah, dan Dewan Perwakilan Rakyat Daerah, telah memberikan kewenangan kepada Dewan Perwakilan Daerah (DPD) untuk melakukan evaluasi dan pemantauan terhadap Perda dan rancangan Perda. Hal tersebut mengindikasikan adanya dualisme kewenangan evaluasi rancangan Perda  antara  Pemerintah  Pusat  dengan  DPD.  Penelitian  ini  berfokus  menjawab  pertanyaan: (a) bagaimana kewenangan pengawasan rancangan Peraturan Daerah dalam sistem hukum Indonesia? (b) bagaimana implikasi dualisme pengawasan rancangan Peraturan Daerah terhadap kepastian hukum pengawasan rancangan Peraturan Daerah dan pengaturan kewenangan urusan pemerintahan yang menjadi domain pemerintahan daerah? Penelitian ini bertujuan untuk menelaah konstruksi pengawasan rancangan Perda dan implikasi dualisme pengawasan rancangan Perda antara DPD dan Pemerintah Pusat. Penelitian ini merupakan penelitian hukum normatif, dengan menganalisis data sekunder berupa peraturan perundangan-undangan dan literatur terkait dengan pengawasan rancangan Perda, khususnya terkait evaluasi rancangan Perda. Hasil penelitian ini menunjukkan bahwa kewenangan pengawasan rancangan Perda oleh DPD secara normatif telah memperluas lingkup rancangan Perda yang dapat dievaluasi, dengan beberapa catatan hukum yang perlu diperhatikan dalam pelaksanaan kewenangan tersebut.
Actors of Belarusian “Multivector” Foreign Policy towards the EU in the 2010s
Authors: Pierson-Lyzhina Ekaterina
Published: December 2020

From 2007 and throughout the 2010s the role of the Belarusian diplomatic service has grown in importance following the adoption of a new foreign policy strategy. The new strategy moved away from focusing solely on Russia and involved engaging with alterative actors such as the EU.

While the diversification of Belarusian foreign policy attracted the attention of a number of scholars, little has been written so far about the elites implementing this change. This article analyses the changes in the Belarusian decision-making and implementation process on questions of foreign policy in the 2010s in comparison with the previous decade. The study also compares career trajectories of Belarusian diplomats working on the EU “vector” with another emerging vector called the “far arc”. All these elements, on one hand, reflect the growing diversity of Minsk’s foreign policy, and, on the other, more specifically the oscillations of foreign policy towards the EU.
Las narraciones de la cuarentena durante la crisis de la COVID-19 a través de la música: emociones y actividades compartidas por Stay Homas
Authors: Alvarez-Cueva Priscila , Masanet Maria-Jose , Cano-Hila Ana Belén
Published: December 2020

“Desconfinamiento” es el título del mix tape de cinco canciones del trío catalán Stay Homas, quienes han sido catalogados como la revelación del confinamiento. El presente estudio concibe estas canciones como narraciones personales. A través de un análisis cualitativo de texto (Krippendorff, 2004), el estudio presenta cinco categorías de elementos que relatan una realidad social vivida dentro del tiempo de cuarentena en Barcelona. Las categorías que el estudio presenta recogen: a) deseos, b) emociones, c) personas, d) prácticas y e) reflexiones, en tiempos de confinamiento. El estudio sostiene que las características descritas en el análisis conectan con las emociones y generan respuestas de interés, empatía y solidaridad más allá de las variantes de la edad, el género y la locación. Las canciones de Stay Homas funcionan como un “antídoto” que suaviza la complejidad de los tiempos que vivimos y sus posibles consecuencias. Finalmente, el estudio discute algunas oportunidades para futuras investigaciones, destacando dos consideraciones: mirar la música como una oportunidad para identificar elementos clave en el acompañamiento emocional, y considerarla como una herramienta que contribuye en el bienestar social.
La toxicidad de la política española en Twitter durante la pandemia de la COVID-19
Authors: Guerrero-Solé Frederic , Philippe Olivier
Published: December 2020

La toxicidad de los mensajes políticos es una creciente amenaza a la confianza que los ciudadanos depositan en el sistema democrático. En particular, las redes sociales son lugares en los que esta toxicidad es más evidente. La pandemia de la COVID-19 y el estado de alarma decretado por el gobierno español parece el contexto ideal para el aumento de la toxicidad en el discurso político. Este artículo analiza la toxicidad de los mensajes de los diputados del Congreso español en Twitter durante el estado de alarma a partir de la herramienta Jigsaw de Google (Conversation AI by conversationai, s. f.; Wulczyn et al., 2017). También se analizan los 15 días anteriores y posteriores a este estado de alarma. El estudio concluye que el periodo del estado de alarma no se caracterizó por un aumento de la toxicidad de los mensajes de los diputados. Observamos, sin embargo, diferencias significativas entre partidos políticos. La extrema derecha de Vox fue el partido más tóxico, seguido por el PP. Finalmente, el estudio también muestra que los políticos hombres tienden a publicar más mensajes tóxicos que las mujeres.
National Grid Connected 3-Phase Inverter based on Photovoltaic Solar System
Authors: Kashan Karam Abdulwahed , Al-Qrimli Fadhil Abbas
Published: December 2020

In this paper, a national grid-connected photovoltaic (PV) system is proposed. It extracts the maximum power point (MPP) using three-incremental-steps perturb and observe (TISP&O) maximum power point tracking (MPPT) method. It improves the classic P&O by using three incremental duty ratio (ΔD) instead of a single one in the conventional P and O MPPT method. Therefore, the system's performance is improved to a higher speed and less power fluctuation around the MPP. The Boost converter controls the MPPT and then is connected to a three-phase voltage source inverter (VSI). This type of inverter needs a high and constant input voltage. A second-order low pass (LC) filter is connected to the output of VSI to reduce the total harmonic distortion (THD) of the output current. The LC filter is then connected to a step-up transformer to push up the low VSI output voltage to the high grid voltage level. The control strategy is based on the rotating reference frame (dq reference frame) and the grid phase shift angle extracted using a phase-locked loop (PLL) technique. The designed PV system supplies only active power with zero reactive power to the utility grid. The system is simulated using MATLAB / Simulink software.
Аdvantages and disadvantages of distance education for future dentists
Authors:   Ukrainian Medical Stomatological Academy, Marchenko А. V. , Nikolishyna E. V. ,   Ukrainian Medical Stomatological Academy, Litovchenko I. Yu. ,   Ukrainian Medical Stomatological Academy, Nikolishyn I. A. ,   Ukrainian Medical Stomatological Academy, Khmil T. A. ,   Ukrainian Medical Stomatological Academy
Published: December 2020

Advantages and disadvantages of distance education of future dentists in Ukrainian Medical Stomatological Academy during quarantine were highlighted. It has been proved that quarantine is not an obstacle to learning, but a reason to study in a new way. In the era of the latest technologies such resources as Internet ones, platforms for online communication, and social networks are the main components for instructors. Different approach to present and perceive educational material is one of the main difficult components during distance education for instructors, students, interns and other audience. Both instructors and interns must master new skills in computer program for on-line communication. Adaptation and perception of distance education occurred in different ways. Majority notes that their time sheet during distance education increased, but opportunities for new methods of training also enhanced. Somebody did not take new method of training because full instructors’ control is absent, so it is necessary to motivate interns to training and self-control. Besides, patient communication should be real not theoretical for future physicians. Development of problem situations, video presentations, and video material prompts to mastering of individual practical skills. So, the experiences in distance education and mastering of dental disciplines by students, interns, physicians give an opportunity to reconstruct educational process in accordance with requirements of modernity for further integration in European (worldwide) medical spread.
Assessment of the relative educational efficiency of the academic staff in the field of health care
Authors:   State University ", Devinyak O. T. ,   Uzhhorod National University", Lytvyn O. V. ,   State University "Uzhhorod National University", Krch K. L. ,   State University "Uzhhorod National University", Kachur I. I. ,   State University "Uzhhorod National University", Meshko A. O. ,   State University "Uzhhorod National University", Deiak Ya. I. ,   State University "Uzhhorod National University"
Published: December 2020

Annual assessment of academic staff and regular publication of the results of such evaluations on the official websites of higher education institutions, on information boards and in any other way is a regulatory requirement laid down in subparagraph 3 of paragraph 2 of Article 16 of the Law of Ukraine «On Higher Education». Existing methods of academic staff assessment found in literature do not allow to make judgments about the quality of educational work, or are based on student surveys and therefore incorporate a number of errors introduced by the subjective nature of assessment. The purpose of this work is to develop an objective way to assess the educational work of academic staff in the field of health care. We propose a system for such assessment, which consists of a subsystem of external independent assessment of students’ knowledge, for example in the format of unified state qualifying exams (USQE: «Step-1», «Step-2», «Step-B» etc.), and a subsystem of internal administrative analysis. The internal administrative analysis subsystem combines the results of students who were taught by a particular teacher in a particular discipline, in the relevant USQE subtest using a special formula and adjusts them to the potential of each student, the complexity of the subtest and the total complexity of USQE in that academic year. The proposed system is implemented in the medical faculty of Uzhhorod National University, and the result of the academic staff assessment was discussed at the academic council of the faculty and at the meetings of departments. The application of the developed system provides an objective assessment of the educational work in the field of health care, and the results of its application are a motivating factor in educational activities and can be taken into account during the renegotiation of contracts for academic staff in higher education.