bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of high-frequency PbtO2 measures in traumatic brain injury: insights into the treatment threshold
Authors: Hirschi Ryan , Hawryluk Gregory W. J. , Nielson Jessica L. , Huie J. Russell , Zimmermann Lara L. , Saigal Rajiv , Ding Quan , Ferguson Adam R. , Manley Geoffrey
Published: November 2018

OBJECTIVE

Brain tissue hypoxia is common after traumatic brain injury (TBI). Technology now exists that can detect brain hypoxia and guide corrective therapy. Current guidelines for the management of severe TBI recommend maintaining partial pressure of brain tissue oxygen (PbtO2) > 15–20 mm Hg; however, uncertainty persists as to the optimal treatment threshold. The object of this study was to better inform the relationship between PbtO2 values and outcome for patients with TBI.

METHODS

PbtO2 measurements were prospectively and automatically collected every minute from consecutive patients admitted to the San Francisco General Hospital neurological ICU during a 6-year period. Mean PbtO2 values in TBI patients as well as the proportion of PbtO2 values below each of 75 thresholds between 0 mm Hg and 75 mm Hg over various epochs up to 30 days from the time of admission were analyzed. Patient outcomes were determined using the Glasgow Outcome Scale. The authors explored putative treatment thresholds by generating 675 separate receiver operating characteristic curves and 675 generalized linear models to examine each 1–mm Hg threshold for various epochs.

RESULTS

A total of 1,380,841 PbtO2 values were recorded in 190 TBI patients. A high proportion of PbtO2 measures were below 20 mm Hg irrespective of the examined epoch. Time below treatment thresholds was more strongly associated with outcome than mean PbtO2. A treatment window was suggested: a threshold of 19 mm Hg most robustly distinguished patients by outcome, especially from days 3–5; however, benefit was suggested from maintaining values at least as high as 33 mm Hg.

CONCLUSIONS

This analysis of high-frequency physiological data substantially informs the relationship between PbtO2 values and outcome. The results suggest a therapeutic window for PbtO2 in TBI patients along with minimum and preferred PbtO2 treatment thresholds, which may be examined in future studies. Traditional treatment thresholds that have the strongest association with outcome may not be optimal.
Cerebral revascularization for the management of complex intracranial aneurysms: a single-center experience
Authors: Nussbaum Eric S. , Kallmes Kevin M. , Lassig Jeffrey P. , Goddard James K. , Madison Michael T. , Nussbaum Leslie A.
Published: November 2018

OBJECTIVE

Because simple intracranial aneurysms (IAs) are increasingly treated endovascularly, neurovascular surgery has become focused on complex IAs that may require deconstructive aneurysm therapy with concomitant surgical bypass. The authors describe the decision-making process concerning cerebral revascularization and present outcomes that were achieved in a large case series of complex IAs managed with cerebral revascularization and parent artery occlusion.

METHODS

The authors retrospectively reviewed the medical records, including neuroimaging studies, operative reports, and follow-up clinic notes, of all patients who were treated at the National Brain Aneurysm Center between July 1997 and June 2015 using cerebral revascularization as part of the management of an IA. They recorded the location, rupture status, and size of each IA, as well as neurological outcome using the modified Rankin Scale (mRS), aneurysm and bypass status at follow-up, and morbidity and mortality.

RESULTS

The authors identified 126 patients who underwent revascularization surgery for 126 complex, atheromatous, calcified, or previously coiled aneurysms. Ninety-seven lesions (77.0%) were unruptured, and 99 (78.6%) were located in the anterior circulation. Aneurysm size was giant (≥ 25 mm) in 101 patients, large (10–24 mm) in 9, and small (≤ 9 mm) in 16 patients. Eighty-four low-flow bypasses were performed in 83 patients (65.9%). High-flow bypass was performed in 32 patients (25.4%). Eleven patients (8.7%) underwent in situ or intracranial-intracranial bypasses. Major morbidity (mRS score 4 or 5) occurred in 2 (2.4%) low-flow cases and 3 (9.1%) high-flow cases. Mortality occurred in 2 (2.4%) low-flow cases and 2 (6.1%) high-flow cases. At the 12-month follow-up, 83 (98.8%) low-flow and 30 (93.8%) high-flow bypasses were patent. Seventy-five patients (90.4%) undergoing low-flow and 28 (84.8%) high-flow bypasses had an mRS score ≤ 2. There were no statistically significant differences in patency rates or complications between low- and high-flow bypasses.

CONCLUSIONS

When treating challenging and complex IAs, incorporating revascularization strategies into the surgical repertoire may contribute to achieving favorable outcomes. In our series, low-flow bypass combined with isolated proximal or distal parent artery occlusion was associated with a low rate of ischemic complications while providing good long-term aneurysm control, potentially supporting its wider utilization in this setting. The authors suggest that consideration should be given to managing complex IAs at high-volume centers that offer a multidisciplinary team approach and the full spectrum of surgical and endovascular treatment options to optimize patient outcomes.
Intravenous infusion of mesenchymal stem cells for protection against brainstem infarction in a persistent basilar artery occlusion model in the adult rat
Authors: Namioka Ai , Namioka Takahiro , Sasaki Masanori , Kataoka-Sasaki Yuko , Oka Shinichi , Nakazaki Masahito , Onodera Rie , Suzuki Junpei , Sasaki Yuichi , Nagahama Hiroshi , Kocsis Jeffery D. , Honmou Osamu
Published: November 2018

OBJECTIVE

Morbidity and mortality in patients with posterior circulation stroke remains an issue despite advances in acute stroke therapies. The intravenous infusion of mesenchymal stem cells (MSCs) elicits therapeutic efficacy in experimental supratentorial stroke models. However, since there are few reliable animal models of ischemia in the posterior circulation, the therapeutic approach with intravenous MSC infusion has not been tested. The objective of this study was to test the hypothesis that intravenously infused MSCs provide functional recovery in a newly developed model of brainstem infarction in rats.

METHODS

Basilar artery (BA) occlusion (BAO) was established in rats by selectively ligating 4 points of the proximal BA with 10-0 nylon monofilament suture. The intravenous infusion of MSCs was performed 1 day after BAO induction. MRI and histological examinations were performed to assess ischemic lesion volume, while multiple behavioral tests were performed to evaluate functional recovery.

RESULTS

The MSC-treated group exhibited a greater reduction in ischemic lesion volume, while behavioral testing indicated that the MSC-infused group had greater improvement than the vehicle group 28 days after the MSC infusion. Accumulated infused MSCs were observed in the ischemic brainstem lesion.

CONCLUSIONS

Infused MSCs may provide neuroprotection to facilitate functional outcomes and reduce ischemic lesion volume as evaluated in a newly developed rat model of persistent BAO.
Simulation workshops as an adjunct to perioperative care bundles in the management of external ventricular drains: improving surgical technique and reducing infection
Authors: Dasgupta Debayan , D’Antona Linda , Aimone Cat Daniel , Toma Ahmed K. , Curtis Carmel , Watkins Laurence D. , Thorne Lewis
Published: November 2018

OBJECTIVE

Temporary CSF diversion through an external ventricular drain (EVD) comes with the risk of EVD-related infections (ERIs). The incidence of ERIs varies from 0.8% to 22%. ERIs increase mortality, morbidity, length of stay, and costs; require prolonged courses of antibiotics; and increase the need for subsequent permanent CSF diversion. The authors report the results of a quality improvement project designed to improve infection rates and EVD placement using simulation training in addition to a standardized perioperative care bundle. This project resulted not only in a decrease in ERIs, but also a significant improvement in surgical outcomes.

METHODS

A best-practice standardized perioperative approach and care bundle was approved by consensus among the senior neurosurgeons at the authors’ institution, and a standardized operative note was designed to encourage adherence to policy and improve documentation. This approach was adapted from the bundle previously described by Kubilay et al. Simulation workshops were introduced to teach safe sampling technique, administration of intrathecal drugs, and a standardized operative technique using the Rowena head surgical model. Effects of the interventions on placement, infection rates, and displacement were measured at two distinct time points over a 2-year period.

RESULTS

Baseline audits demonstrated satisfactory EVD placement in 74%, an infection rate of 8.5%, and displacement occurring in 20%. In the 2 years following the interventions, satisfactory placement improved to 96%, infection rate fell to 4.8%, and inadvertent displacement occurred in only 1.7%.

CONCLUSIONS

Simulation training and standardizing the perioperative care of patients requiring EVDs dramatically improved placement accuracy, reduced infection rates, and reduced EVD displacement rate.
Intravenous infusion of mesenchymal stem cells promotes functional recovery in a rat model of chronic cerebral infarction
Authors: Namioka Takahiro , Namioka Ai , Sasaki Masanori , Kataoka-Sasaki Yuko , Oka Shinichi , Nakazaki Masahito , Onodera Rie , Suzuki Junpei , Sasaki Yuichi , Nagahama Hiroshi , Kocsis Jeffery D. , Honmou Osamu
Published: November 2018

OBJECTIVE

Intravenous infusion of mesenchymal stem cells (MSCs) derived from adult bone marrow improves behavioral function in rat models of cerebral infarction. Although clinical studies are ongoing, most studies have focused on the acute or subacute phase of stroke. In the present study, MSCs derived from bone marrow of rats were intravenously infused 8 weeks after the induction of a middle cerebral artery occlusion (MCAO) to investigate whether delayed systemic injection of MSCs improves functional outcome in the chronic phase of stroke in rats.

METHODS

Eight weeks after induction of the MCAO, the rats were randomized and intravenously infused with either MSCs or vehicle. Ischemic volume and behavioral performance were examined. Blood-brain barrier (BBB) integrity was assessed by quantifying the leakage of Evans blue into the brain parenchyma after intravenous infusion. Immunohistochemical analysis was also performed to evaluate the stability of the BBB.

RESULTS

Motor recovery was better in the MSC-treated group than in the vehicle-treated group, with rapid improvement (evident at 1 week post-infusion). In MSC-treated rats, reduced BBB leakage and increased microvasculature/repair and neovascularization were observed.

CONCLUSIONS

These results indicate that the systemic infusion of MSCs results in functional improvement, which is associated with structural changes in the chronic phase of cerebral infarction, including in the stabilization of the BBB.
Minimal PaO2 threshold after traumatic brain injury and clinical utility of a novel brain oxygenation ratio
Authors: Dellazizzo Laura , Demers Simon-Pierre , Charbonney Emmanuel , Williams Virginie , Serri Karim , Albert Martin , Giguère Jean-François , Laroche Mathieu , Williamson David , Bernard Francis
Published: November 2018

OBJECTIVE

Avoiding decreases in brain tissue oxygenation (PbtO2) after traumatic brain injury (TBI) is important. How best to adjust PbtO2 remains unclear. The authors investigated the association between partial pressure of oxygen (PaO2) and PbtO2 to determine the minimal PaO2 required to maintain PbtO2 above the hypoxic threshold (> 20 mm Hg), accounting for other determinants of PbtO2 and repeated measurements in the same patient. They also explored the clinical utility of a novel concept, the brain oxygenation ratio (BOx ratio = PbtO2/PaO2) to detect overtreatment with the fraction of inspired oxygen (FiO2).

METHODS

A retrospective cohort study at an academic level 1 trauma center included 38 TBI patients who required the insertion of a monitor to measure PbtO2. Various determinants of PbtO2 were collected simultaneously whenever a routine arterial blood gas was drawn. A PbtO2/PaO2 ratio was calculated for each blood gas and plotted over time for each patient. All patients were managed according to a standardized clinical protocol. A mixed effects model was used to account for repeated measurements in the same patient.

RESULTS

A total of 1006 data points were collected. The lowest mean PaO2 observed to maintain PbtO2 above the ischemic threshold was 94 mm Hg. Only PaO2 and cerebral perfusion pressure were predictive of PbtO2 in multivariate analysis. The PbtO2/PaO2 ratio was below 0.15 in 41.7% of all measures and normal PbtO2 values present despite an abnormal ratio in 27.1% of measurements.

CONCLUSIONS

The authors’ results suggest that the minimal PaO2 target to ensure adequate cerebral oxygenation during the first few days after TBI should be higher than that suggested in the Brain Trauma Foundation guidelines. The use of a PbtO2/PaO2 ratio (BOx ratio) may be clinically useful and identifies abnormal O2 delivery mechanisms (cerebral blood flow, diffusion, and cerebral metabolic rate of oxygen) despite normal PbtO2.
Long-term follow-up of pediatric head trauma patients treated at Mulago National Referral Hospital in Uganda
Authors: Vaca Silvia D. , Xu Linda W. , Nalwanga Juliet , Muhumuza Christine , Lerman Benjamin J. , Kiryabwire Joel , Ssenyonjo Hussein , Mukasa John , Muhumuza Michael , Haglund Michael , Grant Gerald
Published: November 2018

OBJECTIVE

There is a paucity of literature on long-term neurosurgical outcomes in sub-Saharan Africa, and as neurosurgical services expand in each country, it would be beneficial to understand the impact of these services on the national population. Since follow-up can be inconsistent, the authors here used the novel method of telephone surveys to conduct the first-ever long-term follow-up in Uganda to elucidate the outcomes of pediatric head trauma patients treated at the national referral hospital.

METHODS

A prospectively maintained database of pediatric head trauma patients treated at the Mulago National Referral Hospital (MNRH) between 2014 and 2015 included 232 patients eligible for this study. Quality of life was assessed through phone surveys conducted by a Ugandan collaborator on site who performed all interviews with the guardian listed at the time of hospital admission, using each participant’s language.

RESULTS

Phone interviews were completed for 142 patients, resulting in a 61% response rate. Including inpatient deaths, the mortality rate was 10%. Almost half of the patients (48%) did not return to MNRH postdischarge, and 37% received no subsequent healthcare at all. Including inpatient deaths, the average Extended Glasgow Outcome Scale–Pediatric Revision (GOSE-Peds) scores for patients with severe, moderate, and mild head trauma were 5.68 ± 2.85, 4.79 ± 2.38, and 3.12 ± 2.08, respectively, at 1 year postinjury and 5.56 ± 2.58, 4.00 ± 2.45, and 2.21 ± 1.49, respectively, at 2 years postinjury.

CONCLUSIONS

This first-ever long-term follow-up of pediatric head trauma patients in Uganda confirmed the feasibility of a novel phone follow-up method for patients throughout Uganda. The results at 2 years showed poor long-term recovery in patients who suffered moderate or severe head trauma but good recovery in patients who suffered mild head trauma. However, there was greater overall disability than that in comparable head trauma studies in the US. The current study lays the groundwork for phone follow-up in low- and middle-income countries as a viable way to obtain outcome data.
Deep brain stimulation for Gilles de la Tourette syndrome in children and youth: a meta-analysis with individual participant data
Authors: Coulombe Marie-Andrée , Elkaim Lior M. , Alotaibi Naif M. , Gorman Daniel A. , Weil Alexander G. , Fallah Aria , Kalia Suneil K. , Lipsman Nir , Lozano Andres M. , Ibrahim George M.
Published: November 2018

OBJECTIVE

Gilles de la Tourette syndrome (GTS) is a disorder characterized by motor and vocal tics. Although by definition the onset of GTS is before age 18 years, clinical trials of deep brain stimulation (DBS) have been conducted only in adults. Using individual participant data (IPD) meta-analysis methodology, the current study investigated the safety and efficacy of DBS as a treatment for GTS in children and youth.

METHODS

A systematic review with no date or language restrictions was performed according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement. Three electronic databases were searched: PubMed, EMBASE, and Web of Science. From 843 articles screened, the IPD of 58 children and youth (ages 12–21 years) extracted from 21 articles were collected and analyzed. A mixed-effects univariable analysis followed by multivariable hierarchical regression was performed using change in the Yale Global Tic Severity Scale (YGTSS) score as the primary outcome and reported measures of comorbidities as secondary outcomes.

RESULTS

The authors’ results showed an average improvement of 57.5% ± 24.6% across studies on the YGTSS. They also found that comorbid depression and stimulation pulse width each correlated negatively with outcome (p < 0.05). In patients with less severe GTS, greater improvements were evident following thalamic stimulation. More than one-quarter (n = 16, 27.6%) of participants experienced side effects, the majority of which were minor.

CONCLUSIONS

DBS in the pediatric population may be an effective option with a moderate safety profile for treatment of GTS in carefully selected children and youth. Large, prospective studies with long-term follow-up are necessary to understand how DBS influences tic symptoms and may alter the natural course of GTS in children.
An efficient in vitro regeneration protocol to generate stable transgenic lines of Black gram (Vigna mungo)
Authors: Sarmah Bidyut Kumar , Konwar Trishna , Borah Borsha , Handique Arun Kumar , Acharjee Sumita
Published: November 2018

An efficient and quick in vitro regeneration protocol was developed for black gram (Vigna mungo) using wounded embryonic axis with cotyledon as explant. Murashige and Skoog (MS) medium supplemented with 4.44 μM BAP and 2.32 μM Kinetin was found to be effective in producing maximum number (mean 7.80) of multiple shoots. The individual shoots elongated to 4.5 cm when MS medium was supplemented with 2.89 μM GA3 along with 0.44 μM BAP and 0.46 μM KIN. A novel in vitro rooting technique was also optimized for black gram using half-strength liquid MS medium supplemented with 1.34 μM NAA. The shoots in this medium produced the highest number (mean 7.50) of roots with root length of 6.02 cm. The plantlets were transferred to soil mixture and placed in greenhouse where more than 80% successfully grew to maturity. The same protocol was successfully used to generate transgenic black gram lines carrying Bt-Cry2Aa gene through Agrobacteriummediated transformation with a transformation efficiency of 0.42%. The rooted T0 plants grew to maturity and produced T1 seeds with the presence and expression of transgene in T1 plants. Thus, we have standardized an in vitro regeneration protocol suitable for generation of stable transgenic black gram plants.
Genetic divergence studies in pearl millet (Pennisetum glaucum L. (R.) Br.) inbred lines
Authors: Bhardwaj Ruchika , Garg Tosh , Malik Ejaz A. , Vikal Yogesh , Sohu R. S. , Gupta S. K.
Published: November 2018

In the present investigation genetic diversity amongst 190 pearl millet accessions viz., 95 maintainer (B line) and 95 restorer lines (R line) was analyzed using SSR markers. A total of 40 SSR primers were used for screening, out of which 34 were polymorphic. PIC value ranged from 0.002 (PSMP 2068) to 0.749 (CTM 60) with an average of 0.445. AMOVA showed greater variance represented by individuals within the group (65%) and between group (B and R lines) variance was less than35%. The neighbor-joining tree based on dissimilarity matrix of germplasm lines differentiated B from R lines into two major clusters with few exceptions of R lines grouping with B lines and vice versa. Genetic dissimilarity estimates ranged from 0.12 (RPR-22; IPC 917) to 0.85 (ICMR 10222; ICMB 97333). The maintainers ICMB 97333, RPB 6 and ICMB 92777 and restorers ICMR 10222, RPR 25, RPR 56, RPR 62 and RPR 40 were identified as most distinct and divergent which could be used as parents for heterosis breeding.
Cross transferability of finger millet and maize genomic SSR markers
for genetic diversity and population structure analysis of barnyard millet
Authors: Babu B. Kalyana , Rashmi C. , Sood Salej
Published: November 2018

The genomic information available in barnyard millet is very scarce though it is a rich source of highly digestible proteins and dietary fibre with good amounts of soluble and insoluble fractions. In the present investigation, 64 maize and finger millet genomic SSRs were used for cross transferability analysis among barnyard millet cultivated and wild species for identification of polymorphic markers, syntenic regions, genetic diversity and population structure analysis. Out of the 64 SSRs, only 39 (61%) were amplified across the barnyard millet genotypes. The PIC values of all the polymorphic loci for 24 barnyard millet genotypes varied from 0.25 to 0.73 at an average of 0.35. Based on the values of different parameters i.e., PIC values (andgt;0.7), gene diversity (andgt;0.6), inbreeding coefficient (andgt;0.27), the SSR loci bnlg2323 and bnlg2123 were observed to be highly polymorphic. Polymorphism comparison of maize and finger millet SSRs revealed that maize microsatellites were highly transferable, more polymorphic and were able to distinguish barnyard millet genotypes clearly. Results of population structure and genetic diversity analysis were similar in differentiating the barnyard millet genotypes into two groups. The structure analysis showed that all genotypes were pure lines (no admixture) while two (IEC514, and IEC409) had mixture of alleles from other genotypes of population which is depicted from the SSRs used in the study. The present study enriched the barnyard millet genetic resources by identifying suitable polymorphic markers of maize and finger millet for diversity analysis, cultivar identification and marker assisted breeding programmes.
Variation for hardseededness and related seed physical parameters
in mung bean [Vigna radiata (L.) Wilczek]
Authors: Chakrabarty S. K. , Paul Debashis , Dikshit H. K. , Singh Y.
Published: November 2018

Presence of hard seeds in seed lots reduces the seedling emergence percentage in field leading to non-uniform and lowered plant population and uneven maturity. Seed hardness, characterized by no water imbibitions, is
controlled by both genetic and environmental factors. The occurrence of hardseededness in 51 mung bean genotypes grown in the field in two seasons (summer and Kharif, 2016) was confirmed by standard germination test. The seed size, 100 seed mass and seed density of identified 20 hard seed and 8 non-hard seed genotypes out of 51 genotypes have been recorded. Hardseededness among the genotypes in original seed lot of Kharif, 2015 ranged from 3 to 52% with a mean of 18.1%. It ranged from 2% to 11% and 3% to 46%, with a mean of 5.42% and 18.35% in summer, 2016 and in kharif, 2016, respectively. In the seed lots of genotypes grown in kharif, 2015 the seed size of selected hard seed genotypes ranged from 3.69/2.90mm (L/ W) to 4.58/3.31mm (L/W) and in selected non-hard seed genotypes it ranged from 4.01/2.46mm (L/W) to 4.83/3.48mm (L/W). The 100 seed mass in selected hard and non-hard seed genotypes ranged from 2.69 to 4.13g and 2.39 to 3.94g, respectively, in kharif, 2015. In summer, 2016, it ranged from 3.57 to 4.75g and 3.05 to 5.58g in selected hard seeded and non-hard seeded genotypes, respectively. A higher seed density of hardseeded genotypes was recorded in comparison to that of non-hard seeded genotypes. In summer, 2016 the genotypes like Pant M-5, GM-4, IPM 02/3, AKM 9904, PS-16, SM-11/75, HUM-12, IPM 205/7 showed lower occurrence of per cent hard seeds. The broad sense heritability estimates for the hardseededness in the kharif and summer season ranged between 0.96 to 0.98 and 0.67, respectively. A larger seed size in genotypes grown in summer season showing lower occurrence of hard seeds suggest that the summer season is the desired season for quality seed production of genotypes with higher percentage of hard seeds.
Planiranje dizajna i razvoj poslovne aplikacije nad
relacijskom bazom podataka – iz studentske perspektive
Authors: Šimičić Maša , Poščić Patrizia , Jakšić Danijela
Published: November 2018

This scientific article describes design planning and development of the business database application “Laundry“ for an association named “Terra“ in the city of Rijeka. The idea for a business
application came during a conversation with the “Oaza“ association employee in Rijeka. Application design planning was preceded by interviewing people which was indispensable in order to make a list of user requirements.These user requirements were needed for developing a relational database in Clarion, Entity – relationship model and for relation model. This article contains pictures as examples of the most important parts of the application made in Clarion program with a matching description. The work resulted in a complete application for the business system association “Terra’s Laundry“ in Rijeka. When the application was done, the meeting was arranged so that the application could be presented to “Terra’s Laundry’s“ employees. At the presentation of the application the employees were expected to comment and say what should be changed, added or removed from the application. In line with what was said at the meeting, the application was modified and finally it was ready to be installaled on the “Terra’s Laundry“ main computer. It was also necessary to install a program for automatic backup in order to make its security copy on daily basis.
What makes summer vacation experience
memorable? An empirical study from Croatia
Authors: Lončarić Dina , Dlačić Jasmina , Perišić Prodan Marina
Published: November 2018

This paper aims to examine what kind of experience makes summer vacation memorable and consequently how it influences the overall satisfaction with a vacation experience. Based on literature review hypotheses were formulated in order to explore the multidimensionality of memorable tourist experience, the influence of different elements of memorable tourist experience on satisfaction with tourist vacation as well as the influence of satisfaction with vacation experience on the behavioural intention of tourists. For the purpose of the research, empirical research using paper and pencil questionnaire was carried out on the sample of 134 international tourists who visited traditional sun and sea destinations in Croatia in a broader Kvarner region during the summer of 2017. The research results, although of indicative nature only, point out that a memorable tourist experience consists of four different factors, namely hedonism and novelty, local culture, involvement and refreshment.
Among them, local culture has the highest impact on overall satisfaction with summer vacation experience. Also, refreshment as a memorable tourist experience influences the overall vacation satisfaction. The research has also confirmed the positive relationship between the following elements: satisfaction with vacation experience on behavioural intentions that were measured through tourists’ intention to return to the destination, to recommend the destination to their friends and relatives, to share experience through social media and to spend more money in tourist destinations. The strongest relationship is between tourist satisfaction with vacation experience and the intention to recommend a destination followed by intention to revisit that destination if they feel satisfied with the experience provided. Managerial implications as well as limitations and ideas for further research are given.
Razvoj modela muzeja sigurnosne opreme
Authors: Miličić Mario , Dundović Kristina , Martins Isidoro Rui
Published: November 2018

Sigurnost na radu bilježi svoje početke od ranih civilizacija, pa sve do
današnjeg modernog doba. Kako se povijest sigurnosti na radu ne bi zaboravila, potrebno je stvoriti muzej u kojem će se omogućiti njen prikaz, o čemu govori ovaj rad. U radu su dani povijesni teorijski prikazi zaštite na radu u pojedinim područjima ljudske djelatnosti. Daje se opširan pregled muzeja, što uključuje razne planove, artefakte, modernu sigurnosnu opremu, aktivnosti, ostalu opremu za rad, elektronički muzej i troškove. Zadatak muzeja sigurnosne opreme je educirati ljude o važnosti sigurnosti na radu, što znači implementirati svijest o zaštiti na radu, kako bi se postigla planirana prevencija s ciljem sprječavanja ili smanjena rizika na radnom mjestu i izvan njega. Prikazat ćemo rezultate projekta i predviđanja za daljnji razvoj.
Labelling of food products
Authors: Štefanić Ivan
Published: November 2018

Declaring nutritional characteristics, expiration dates and instructions
for safe preparation of food, substances causing potential allergies or
intolerances contained in products may be of vital importance to buyers
and consumers. Additional information, such as geographical indication or origin of the food and compliance with certain standards could play a
decisive role in purchasing decisions. A comprehensive search of regulatory framework of food production, processing, distribution and labelling is conducted at the Croatian and EU level. Appropriate emphasis is given to the food-related legislation, marketing and intellectual property related legislation. Special attention is given to
the declaration of: nutritional characteristics, substances or products causing allergies or intolerances; geographical indication and origin of
the food; quality seals; medicinal claims, organic food claims, and redundant, confusing and misleading signs. Legal obligations regarding mandatory food labelling are limited in terms of information. Voluntary food labelling can offer a large array of additional information, but it
is still regulated in a very precise manner. Marketing communication, regarding their own brands, is an important component of the business for several reasons; it is an effective signpost for repeated purchases; an entry barrier into the sector or possible sources of additional revenue. Manufacturers and traders can voluntarily apply labelling standards that are more stringent than minimally prescribed ones. In this way, they communicate their concern for customers’ well-being and possibly achieve a competitive advantage over producers who do not demonstrate such a degree of social responsibility in their business.
Decline
of arable flora diversity in Istria (from the year 2005 to the year 2017)
Authors: Štefanić Edita , Kovačević Vesna , Antunović Slavica
Published: November 2018

Changes in floristic composition of weed flora were assessed comparing two phytocoenological surveys carried out during vegetation seasons in 2005 and in 2017 on the Istrian Peninsula. A total of 50 fields (row crops, cereals, alfalfa fields, orchards/vineyards and ruderal areas) were surveyed for each of the sampling time using Braun-Blanquet cover-abundance scale. Altogether 175 vascular plant species were recognized in both investigations. The most abundant species in 2005 were Avena fatua, Setaria verticilata, Lolium multiflorum and Veronica persica. In the recent survey these species became very rare or were even not detected in some habitats. In contrast, some species with very low relative abundance or not recorded in the earlier survey were found abundant in 2017. These are: Pastinaca sativa, Conyza canadensis, Picris
echioides, Polygonum aviculare, and Heliotropium europaeum. The species
richness was significantly higher in the earlier survey when 143 (82%) weeds were detected compared to only 97 species (55%) found in 2017. Only 64 species were found in both surveys, and these were considered frequent weeds. The comparison of weed communities
from the earlier to the recent survey reflects the reduction of the weed flora at the regional scale, as well as at the field scale. The mean values of Shannon-Wiener diversity index were also higher in the earlier period and it decreased over time, particularly in row crops, cereals and ruderal habitats. This decrease was related to decline of species richness, and to the increase in inequality in the relative abundance of species. On the whole, canonical correspondence analysis indicated the major variations in species composition between different habitats.
Treba li oporezivati kupnju nekretnina u Hrvatskoj?
Authors: Baljak Božena , Zaninović Vinko , Tomas Žiković Ivana , Štambuk Ana , Blažić Helena
Published: November 2018

Porez na promet nekretnina u širokoj je međunarodnoj primjeni, iako je to jedan od imovinskih poreza s većim distorzivnim učinkom od većine ostalih imovinskih poreza. Stoga je glavni cilj ovog istraživanja ispitati stavove stanovništva Republike Hrvatske o ovom porezu, dok ostali ciljevi obuhvaćaju utjecaj relevantnih demografskih i ekonomskih varijabli na ovaj stav. Podaci su se prikupljali telefonskom anketom na području cijele Hrvatske. Obrađeni su ordinalnom logističkom regresijom te procjenom graničnog učinka svake varijable. Medijan i mod odgovora iznose 3 (neutralan odgovor s obzirom na raspon odgovora 1 - 5), što znači da stanovništvo nema izražen stav niti protiv niti u korist ovog oporezivanja. Utvrđeno je da ga odobravaju osobe koje žive u urbanom području i one koji imaju viši stupanj obrazovanja. Negativan stav iskazali su ispitanici ženskog spola, oni koji štede u banci, a utvrđen je i regionalni utjecaj (stanovništvo koje živi u južnim dijelovima Hrvatske ima negativniji stav o ovom oporezivanju).
Socijalno poželjno
odgovaranje i vrijeme latencije u kontekstu selekcijskoga postupka pri
zapošljavanju
Authors: Fiškuš Matej , Švegar Domagoj
Published: November 2018

Socijalno poželjno odgovaranje definira se kao sistematska tendencija davanja pretjerano pozitivnih samoprocjena i često se potvrđuje prilikom selekcijskog postupka.
Cilj je ovog istraživanja bio utvrditi postoji li razlika u davanju socijalno poželjnih odgovora i u brzini odgovaranja između osoba koje se prijavljuju na natječaj za posao i kontrolne skupine ispitanika. Uzorak se sastojao od ukupno 252 ispitanika.
Eksperimentalna skupina brojila je 94 kandidata koji se za posao prijavljuju na profesionalnoj društvenoj mreži (www.linkedin.com) i jednom domaćem portalu (www.bika.net), na kojem se oglašavaju slobodna radna mjesta, dok je u kontrolnoj skupini bilo 158 sudionika koji su odgovarali na ista pitanja kao i kandidati za posao. Web-upitnik se sastojao od ukupno 36 čestica preuzetih iz Eysenckove skale laži i Paulhusove skale samozavaravanja. Multivarijantnom analizom varijance ustanovljeno je da kandidati prilikom prijave za posao daju više socijalno poželjnih odgovora te da odgovaraju sporije u odnosu na sudionike iz kontrolne grupe. Rezultati diskriminantne analize sugeriraju da bi se vrijeme latencije moglo koristiti kao indikator socijalno poželjnog odgovaranja. Razmotrene su implikacije i prijedlozi za buduća istraživanja.
Filmska industrija kao promotor turističke
destinacije za mlađu populaciju
Authors: Bagarić Lidija , Meštrović Dunja , Jelić Antonia
Published: November 2018

Filmski turizam postaje sve popularniji na globalnom turističkom tržištu, konkurencija među destinacijama domaćinima sve je veća, pa se ulažu veliki napori u privlačenju filmskih setova, a filmski lokaliteti odigravaju značajnu ulogu u planiranju marketinških aktivnosti turističkih destinacija. Ovim radom nastoji se istražiti utjecaj gledanja filmova na odluku o odabiru turističke destinacije kod mlađe populacije. Postavljene su hipoteze koje pretpostavljaju da filmovi utječu na odluku ispitanika prilikom odabira turističke destinacije te da je filmska priča presudna u odabiru destinacije prikazane u filmu. U cilju dokazivanja postavljenih hipoteza provedeno je kvantitativno istraživanje. Ispitanici su odgovarali na pitanja koja se odnose na njihove navike gledanja filmova, navike i preferencije tijekom putovanja, želje i potrebe prilikom izbora turističke destinacije viđene
u filmu, na informacije o već ostvarenim putovanjima u svrhu posjeta filmskim destinacijama i događajima, te na pitanja koja se odnose na njihove želje i buduće namjere prilikom odabira turističke destinacije. Podaci su analizirani primjenom metoda deskriptivne i induktivne statistike, hipoteze su testirane i doneseni su zaključci o povezanosti primjenom izračuna hi-kvadrat testa. Rezultati istraživanja pokazali su značajnu povezanost učestalosti gledanja filmova ispitanika s njihovom odlukom o odabiru turističke destinacije, a kao poticaji za posjet destinaciji pokazali su se ljepota krajolika, specifične lokacije iz filma i kulturno-povijesne znamenitosti.

Istraživanje je provedeno na prigodnom uzorku, pa interpretaciju i generalizaciju rezultata treba uzeti u obzir s dozom opreza. S obzirom na porast broja međunarodnih filmskih produkcija tijekom posljednjih godina, filmski turizam u Hrvatskoj bilježi značajan rast pa rezultati ovog istraživanja mogu poslužiti kao putokaz za planiranje marketinških aktivnosti i brendiranje Hrvatske kao filmske destinacije.
Ensayo episódico de la vida internacional de México de 1848 a 1876
Authors: Herrera León Fabián
Published: November 2018

El presente artículo fue intencionalmente concebido como una narración de sucesos relativos a la vida internacional de México durante la segunda mitad del siglo XIX, y tiene como propósito introducir al estudio de la historia de las relaciones internacionales. Los referentes bibliográficos que aprovecha son obras de corte general y de reconocidos divulgadores y polemistas del pasado mexicano que inclusive han inspirado la prosa tajante con que está escrito.
Registration of ‘Tamalpais’ Barley
Authors: Krill-Brown Allison , Jackson L. F. , Gallagher L. W.
Published: November 2018

‘Tamalpais’ (Reg. No. CV‐367, PI 645477) is a six‐rowed, naked grained food/feed spring barley (Hordeum vulgare L.) released by the University of California Agricultural Experiment Station in 2008. It is medium maturing and medium‐short in height, with good straw strength. It has full, rough awns and good resistance to shattering. As a hull‐less (naked) feed/food barley, Tamalpais should appeal to growers of organic barley for human consumption as a whole grain in cereals, soups, and breads. Tamalpais is high in β‐glucan (>6%), a measure of soluble fiber, and may be useful in lowering human cholesterol levels. Other markets include the bird seed and pet food industries. It is resistant to leaf rust and powdery mildew, moderately resistant to scald, net blotch, and Barley yellow dwarf virus, and moderately susceptible to stripe rust. It was evaluated as Entry UC 1134 in the University of California Regional Cereal Testing program from 2004 to 2017 for late fall planting in the Central Valley and the south‐central coastal region of California.
CERIUM(III) CARBONATE HYDROXIDE NANOPARTICLES ENCRUSTED BY METALLIC PALLADIUM. SYNTHESIS AND INVESTIGATION
Authors: Buslaeva T. , Kopylova E. , Popenko V. , Potapova A. , Fomichev V.
Published: November 2018

Cerium(III) nitrate and urea solution mixture were treated by hydrothermal and microwavehydrothermal methods, as a result cerium(III) carbonate hydroxide nanoparticles (22-37 nm) were obtained. Cerium(III) carbonate hydroxide nanoparticles, encrusted by palladium were obtained using palladium reduction process from cerium(III) carbonate hydroxide solution. It is shown, that palladium occurrence disturbs hard hydrogen bond system, leading to carbonate hydroxide nanoparticles structure disorder and also increases efficiency of catalytic reactivity process.
DEPENDENCE OF EXTERNAL AND INTERNAL ENERGY-SAVING FOR RECTIFICATION OF BINARY MIXTURES
Authors: Zakharov M. K. , Shvets A. A.
Published: November 2018

The comparison of energy consumption for rectification of binary mixtures in one-column and twocolumn apparatuses was carried out with the use of vapor flow energy from the first column for heating the second column. It is shown that the expected two-fold reduction of the flow of heat energy is impossible due to the decrease of the internal energy-saving.
WAYS OF IMPROVING THE SPECIFICITY OF THE LATEX AGGLUTINATION REACTION
Authors: Sandzhieva A. V. , Bakhtina A. V. , Sivaev А. А. , Basyreva L. Yu. , Gusev S. A. , Gritskova I. A.
Published: November 2018

The article describes research on the development of new diagnostic test systems operating on the basis of latex agglutination reaction, in which polymer microspheres are used as bioligand carriers instead of erythrocytes. Polymeric microspheres to be used as bioligand carriers must satisfy the following requirements: narrow size distribution, diameter of 5 microns. Besides, they must be characterized by aggregative stability in water and buffer solutions and be contained functional groups in the surface layer for linking with the functional groups of the protein. They are crosslinked particles obtained by copolymerization of styrene and divinylbenzene on polystyrene seed particles 1.5 microns in diameter with a narrow size distribution followed by modification by chloromethylation and amination by ethylenediamine. To increase the hydrophilicity of the surface of the polymer microspheres and to reduce nonspecific adsorption of proteins dextran was immobilized on the surface of the particles by covalent binding with amino groups of particles using Maillard reaction. It was found that diagnostic test systems, where modified dextran particles were used as carriers of the bioligand (Vi-antigen), are characterized by insufficient specificity and require additional modification of the surface of the polymer microspheres to eliminate its non-specific interaction with the surface of the polymer plate used for the latex agglutination reaction. A nonionic surfactant (Tween 80) proposed for the surface modification and used in a certain concentration provides the best reaction specificity.
VAPOUR-LIQUID EQUILIBRIUM IN SYSTEMS WITH ISOBUTYL ACETATE, ACETIC ACID AND METHYL ETHYL KETONE
Authors: Zhuchkov V. I. , Nazansky S. L. , Krupinova O. N. , Frolkova A. K.
Published: November 2018

The experimental temperature dependence of the vapour pressures of isobutyl acetate, acetic acid and methyl ethyl ketone were determined, and isobaric vapour-liquid equilibrium data of binary systems of methyl ethyl ketone + isobutyl acetate and methyl ethyl ketone + acetic acid were obtained. The experimental data were processed using the Antoine and Riedel equations and the NRTL and Wilson local composition equations, respectively. Comparison of the experimental and calculated data confirmed the adequacy of the vapour-liquid equilibrium mathematical simulation.
HOMOATOMIC POLYHEDRAL EXTENSION IN NONAHYDRO-closo-NONABORATE ANION [B9H9]2-
Authors: Bykov A. Yu. , Selivanov N. A. , Zhdanov A. P. , Zhizhin K. Yu. , Kuznetsov N. T.
Published: November 2018

Nonahydro-closo-nonaborate anion possess the property of structural nonrigidity because of presence of three low-coordinated boron atoms. So it’s able to come into the reactions of polyhedral extension. This paper is devoted to the reactions of homoatomic polyhedral extension in nonahydrocloso-nonaborate anion [B9H9]2- in presence of triethylaminborane complex BH3·(C2H5)3N. It was shown that mixes of [B10H10]2- and [B12H12]2- salts in various molar ratios had been formed as products. These ratios depend on proportion of reagents. In presence of excess of triethylamin borane complex the molar ratio of products is 1:1. When equimolar amount of triethyamminborane complex used, the selectivity of process shifted to formation of [B10H10]2- anion. However the formation of [B12H12]2- still occurs in this conditions but the molar ratio of [B10H10]2-:[B12H12]2- is 5:1.
THE INFLUNCE OF TEMPERATURE MODE ON KINETICS OF SODIUM METHACRYLATE AND METHACRYLIC ACID AMIDE COPOLYMERIZATION
Authors: Lipin А. А. , Lipin А. G. , Shibashov А. V.
Published: November 2018

Experimental studies of sodium methacrylate and methacrylamide copolymerization in aqueous solutions with a total monomer content of 34-50% were accomplished. Potassium persulfate was used as the initiator. Three variants of the process operation conditions were investigated: isothermal, quasi-isothermal and adiabatic. The effect of temperature, initial concentration of monomers and initiator on the rate of copolymerization, the extent of monomers conversion, the duration of the process, the reaction mass viscosity were studied under isothermal conditions. The copolymerization takes place at a constant rate at all temperatures in the range of 55-80°C until conversion is less than 70%. This behavior is typical for the polymerization system with initial total concentration of monomers of about 4.4 mol·L-1 and above. It is found that the reaction rate is directly proportional to the initial concentration of the reaction system. Increasing temperature reduces the viscosity of a 1% aqueous solution of the product, thus reducing the average molecular weight of the copolymer. By means of studying the copolymerization under adiabatic conditions the dependences of the monomers conversion degree, the viscosity of a 1% aqueous solution of the product and the reaction mass temperature upon copolymerization time were obtained. In the adiabatic mode the monomers conversion is less than 70%, the viscosity of a 1% solution of the reaction mass is approximately 13·10-6 m2/s, and the temperature rises to ~ 120°C. The product is a polymer gel, water-swellable and soluble in an aqueous alkaline medium. The quasi-isothermal mode of copolymerization with the same duration allows obtaining the degree of conversion of about 94% and a viscosity of the reaction mass of about 400·10-6 m2/s. An important advantage of the copolymer obtained in the quasi-isothermal mode as compared to that obtained in the adiabatic conditions is complete water solubility. Based on experimental results, the recommended conditions for the sodium methacrylate and methacrylamide copolymerization are as follows: the monomers concentration in the reaction mass is 5.55-6.75 mol·L-1; initiator concentration is 2·10-3 - 6·10-3 mol·L-1; copolymerization temperature is 55-65°C.