bluuebunny/crossref_metadata_2025 huggingface dataset:
Rahanat Tawzif al-Lughah al-Arabiyah fi Maydan al-Siyahah
Authors: Benouargla Nadia
Published: June 2023

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Ta’lim al-Lughah al-‘Arabiyah fi Indunisiya: Al-Waqi’ wa al-Mustaqbal
Authors: Busyairi Lalu Ahmad
Published: June 2023

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Surface roughness assessment with fluoride varnish application: An in vitro study
Authors: Apriani Anie , Naliani Silvia , Djuanda Rudy , Teanindar Shania Hysan , Florenthe Jessica Quiteria , Baharudin Ferri
Published: June 2023

Background: The cause of cavities is initially due to roughness on the tooth surface, requiring fluoride varnish to prevent caries, as the varnish applies a fluoride compound to the tooth surface. Fluoride varnish reacts with the tooth enamel surface to form calcium fluoride and fluorapatite, thus making the enamel surface more resistant to demineralization and damage. Purpose: This study aims to compare the roughness of tooth enamel surfaces among three fluoride varnishes under acidic conditions. Methods: The research method uses three fluoride varnish materials: sodium fluoride 5% + tricalcium phosphate, calcium fluoride, and sodium fluoride 5% + casein phosphopeptide-amorphous calcium phosphate 2%. Samples of 81 teeth were divided into three groups (Group 1 without fluoride varnish application, Group 2 application of fluoride varnish with pH 3, and Group 3 application of fluoride varnish with pH 5). The teeth were tested before and after application of the varnishes using the scanning electron microscope and surface roughness tests. Results: The results showed a significant difference in the mean surface roughness of the enamel of the anterior deciduous teeth tested with fluoride varnish. The before and after comparisons in the pH 3 and pH 5 groups were very significant (p-value 0.000). The comparison results in each pH group after fluoride varnish administration showed no significant difference (pH 3 p-value 0.074 and pH 5 p-value 0.196). The tooth surfaces appear to be rougher after administration of an all-acid solution. Conclusion: There is a difference in surface roughness of primary teeth after being given fluoride varnish in low pH 3 immersion for 24 hours.
The early detection of tongue cancer with the etiology of mechanical trauma
Authors: Setyawan Aris , Anang Zhavira Dwiyanti , Rahmawati Rizki Nurida , Kumalasari Winda , Noor Alfi Dian Uly , Yulianti Rima Talitha
Published: June 2023

Background: Oral squamous cell carcinoma (OSCC) occurs in approximately 95% of people older than 40 years; usually, it is diagnosed at the age of 60 years. The etiology of OSCC is multifactorial. Chronic mechanical trauma due to sharp teeth has also been suggested as an etiology of oral squamous of the tongue. Purpose: This case report aimed to describe the etiology of OSCC resulting from mechanical trauma and to prevent further metastasis by correctly diagnosing the lesion earlier. Case: A 49-year-old female patient presented with painful and swollen stomatitis two months ago. No submandibular lymph nodes were palpable. An indurated ulceration and sharp teeth on the right region of the jaw were obtained from the intraoral examination. Malignancy was concluded from Histopathology Examination (HPE) and Magnetic Resonance Imaging (MRI) radiography results. Case Management: Multiple extractions were chosen to eliminate the etiology of mechanical trauma due to sharp teeth, and the patient underwent hemiglossectomy with the keyhole method. Postoperative, the histopathology examination revealed an OSCC of the tongue. The patient is currently in the second cycle of chemotherapy by hematologist-oncologists. Conclusion: The early appropriate diagnosis of a tongue ulcer can prevent metastasis, decrease morbidity, and increase quality of life.
Interaction of pregnane X receptor with hypoxia-inducible factor-1 regulates chemoresistance of prostate cancer cells
Authors: Wang Jiuhui , Nie Daotai
Published: June 2023

Aim: The nuclear pregnane X receptor (PXR) is a pivotal regulator of steroid and xenobiotics metabolism and plays an important role in shaping tumor cell responses to chemotherapy. Hypoxia within tumor tissue has multifaceted effects, including multiple drug resistance. The goal of this study was to determine whether PXR contributes to hypoxia-induced drug resistance. Methods: Metastatic prostate cancer cells were used to study the interaction of PXR and hypoxia-inducible factor-1 (HIF-1 in drug resistance associated with hypoxia. The activities of PXR and HIF-1 were determined by assays for its reporter gene or target gene expression. Co-immunoprecipitation (Co-IP) was used to determine the interaction of PXR and HIF-1. Ablation or inhibition of PXR or HIF-1 was used to determine their roles in hypoxia-induced chemoresistance. Results: PXR was activated by hypoxia, leading to increased expression of multidrug resistance protein 1 (MDR1). Inhibition of PXR by pharmacological compounds or depletion by shRNAs reduced the hypoxic induction of MDR1 and sensitized prostate cancer cells to chemotherapy under hypoxia. HIF-1 was required for PXR activation under hypoxia. Co-immunoprecipitation results showed that HIF-1 and PXR could physically interact with each other, leading to crosstalk between these two transcription factors. Conclusion: PXR contributes to hypoxia-induced drug resistance in prostate cancer cells through its interaction with HIF-1.
Fabrication and Characterization of Copper and Copper Alloys Reinforced with Graphene
Authors: Bident Antoine , Caillault Nathalie , Delange Florence , Labrugère-Sarroste Christine , Lu Yongfeng , Silvain Jean-Francois
Published: June 2023

The constant increase in current density in electrical wires leads to increasingly significant heat losses due to Joule effect. Therefore, reducing the electrical resistivity of copper wires becomes necessary. To achieve this goal, the development of a composite material incorporating a more conductive reinforcement, the graphene, is a promising way. The design of a copper/graphene composite using a powder metallurgy-based method is presented. This synthesis method allows for interface control through the growth of CuO(Cu) nanoparticles tightly bonded to the reinforcement. It also involves the dispersion of graphene through ultrasonic treatment and its alignment within the matrix using a uniaxial pressing densification method. The increase in the hardness (+12 HV) demonstrates the effective dispersion and separation of graphene layers. The impact on the electrical properties of dendritic copper (ρe = 2.30 µΩ.cm) remains limited, with a decrease in electrical resistance of approximately 1.4%. However, for copper with higher electrical resistivity, flake copper (at 2.71 µΩ.cm) and brass at (7.66 µΩ.cm), reductions of 2.7% and 10% have been achieved, respectively. With the improvement of graphene quality, there is more room to improve the electrical properties. This work paves the way for the development of composites with improved electrical resistivity.
Direct Optical Patterning of Quantum Dots: One Strategy Different Chemical Processes
Authors: Antolini Francesco
Published: June 2023

Patterning, stability, and dispersion of the semiconductor quantum dots (scQDs) are the three issues strictly interconnected for successful device manufacturing. Recently several authors adopted direct optical patterning (DOP) as a step forward in photolithography to position the scQDs in a selected area. However, the chemistry behind the stability, dispersion, and patterning has to be carefully integrated to obtain a functional and therefore, commercial device. In this review are described different chemical strategies suitable to stabilize the scQDs both at a single level and as an ensemble with a special focus on the ones compatible with direct optical patterning (DOP). With the same purpose, the scQDs dispersion in a matrix was described in terms of the scQDs surface ligands interactions with the matrix itself. The chemical processes behind the DOP are illustrated and discussed for five different approaches that consider together stability, dispersion, and the patterning itself of the scQDs.
Effect of Tree Size Heterogeneity on the Overall Growth Trend of Trees in Coniferous Forests of the Tibetan Plateau
Authors: Wang Yuelin , Shu Shumiao , Wang Xiaodan , Chen Wende
Published: June 2023

Tree growth is under the combined influence of abiotic and biotic factors. Trees with different sizes may respond differently to these factors, implying that tree heterogeneity in tree size may also modulate the overall growth trend. To test this hypothesis, we focused on the radial growth trends of natural subalpine forests on the Tibetan Plateau. We first extended the iterative growth model (IGM) to the tree-ring scale (IGMR) to test the applicability of the generalized metabolic growth theory to tree growth. As predicted by the IGMR, the radial growth of trees at the aggregate scale is constrained by a unimodal pattern. Using the IGMR, we reconstructed the historical best growth trajectory (HBGT) of trees within the same community based on the tree with the largest radius and/or longest age in the community. From the average difference between the HBGT and the current radial growth rate of trees with different sizes, we constructed an indicator that can measure the overall variation in tree radial growth. Based on this indicator, we found a negative effect of tree size heterogeneity on the overall variability of tree growth across elevations. Further analysis also revealed that the radial growth rate of trees on the Tibetan Plateau has increased significantly compared to the past, where growing season average temperature and annual minimum temperature were negatively and positively correlated with tree growth below and above the treeline, respectively. Our study not only confirmed that the overall variability of tree growth depends on tree size heterogeneity but also proposed an indicator that reveals net changes in tree radial growth rate relative to the past. These theoretical advances facilitate the understanding of changes in the extent of subalpine forests.
Ink Mismatch Detection From Hyperspectral Image Document
Authors: jabeen Nadia
Published: June 2023

Forensic document examiners can determine the authenticity of questioned documents by analyzing the ink used to create them. If an ink mismatch is found, it could be a sign of scam, backdating, or forgery. In this research a Hyperspectral Images of iVision HHID dataset is used to detect number of possible inks used in document. By using Hyperspectral Images, it’s possible to detect ink mismatch in a given document. In this research unsupervised learning method K-means is used to detect number of inks. Approximate number of clusters are determined by Elbow and Silhouette method before implementation of K-means.
Pseudovitelliform Maculopathy Associated with Hereditary Hemochromatosis: Two Case Reports
Authors: Vukojević Ante , Vukojević Marija , Jukić Tomislav , Petriček Igor , Mandić Krešimir , Vukojević Nenad
Published: June 2023

Hereditary hemochromatosis (HH) is an inherited iron metabolism disorder. It is caused by an autosomal recessive disorder resulting from a C28Y8 HFE gene mutation. Mutations in the HFE gene may result in iron accumulation and oxidative stress in the retina, resulting in macular degeneration. This article describes two patients with HH who developed vision difficulties. Both patients were subjected to a retinal exam, multimodal imaging, and electrodiagnostic techniques, which revealed structural and functional degeneration of the central macula. Fundus photography, fluorescein angiography (FA), and fundus autofluorescence (FAF) revealed changes at the level of the retinal pigment epithelium (RPE) in the center of the macula, while optical coherence tomography (OCT) revealed subfoveal accumulation of hyperreflective material at and below the RPE. The multifocal electroretinogram (mfERG) confirmed a decreased cone response, whereas the full-field electroretinogram (ERG) revealed no pathological findings. In addition, patients underwent genetic testing, which ruled out the possibility of hereditary macular dystrophy. Considering macula findings and the nature of the patients' primary illness, we believe that the higher concentration and accumulation of iron and photoreceptor metabolic products have led to dysfunction in the RPE, which has led to morphological and functional changes in the macula.
Stress Responses in Saccharomyces cerevisiae: The Role of PKA Signalling Pathway
Authors: Portela Paula , Bermúdez-Moretti Mariana , Ortolá Martínez María Clara , Galello Fiorella , Rossi Silvia
Published: June 2023

The yeast Saccharomyces cerevisiae is widely used in food and nonfood industries. During industrial fermentations yeast are exposed to fluctuations in oxygen concentration, osmotic pressure, pH, ethanol concentration, nutrient availability and temperature. Fermentation performance depends on the ability of different yeast strains to adapt to these changes. Suboptimal growth conditions trigger responses to these external stimuli to allow cellular homeostasis to be maintained. Stress-specific signaling pathways are activated to coordinate changes in tran-scription, translation, protein function, and metabolic fluxes while a transient arrest of growth and cell cycle progression occur. cAMP-PKA, HOG-MAPK and CWI signalling pathways are signal transduction pathways turned on during stress re-sponse. Comprehension of the mechanisms involved in the responses and in the adaptation to these stresses during fermentation is key to improving this industrial process. The scope of this review is to outline the advancement of knowledge about the cAMP-PKA signalling and the crosstalk of this pathway with the CWI and HOG-MAPK cascades in response to the environmental challenges heat and hy-perosmotic stress.
Quantitative Fit Testing on Filtering Facepiece Respirators in Use by Peruvian Healthcare Workers Caring for Tuberculosis Patients During the COVID-19 Pandemic: PROFIT Study 2020
Authors: Inolopú Jorge , Mayma Kevin , Curisinche-Rojas Maricela , Aylas Rula , Flores Juan A. , Rosales Jaime
Published: June 2023

Background: The COVID-19 pandemic has promoted a shortage of filtering facepiece respirators (FFRs) and the emergence of new FFRs brands. We aimed to determine the fit provided by in-use FFRs in Peruvian healthcare workers (HCWs) during the COVID-19 pandemic. Methods: We enrolled 279 HCWs from 37 primary healthcare centers with highest burden of care for TB in Peru, of which 263 were assessed using quantitative fit tests (QNFT). Results were expressed as real-time fit factor (rt-FF) and overall fit factor (overall-FF), which was categorized as ≥100 (optimal result), 50-99, and <50. Results: We identified 3M 1860 FFRs (33.1%), Xiantao Zhong Yi ZYB-11 FFRs (24.7%) and Makrite 9500 FFRs (20.5%), mainly. Eighty-seven HCWs (33.1%) had an optimal overall-FF, 27 (10.3%) between 50-99, and 149 (56.7%) less than 50. Of the 87 HCWs with optimal over-all-FF, 73 (83.9%) were 3M 1860 FFR. Of the 27 participants with overall-FF between 50-99, 7 (25.9%) were Makrite 9500, while of the 149 with overall-FF less than 50, 58 (38.9%), and 47 (31.5%) were Xiantao Zhong Yi ZYB-11 and Makrite 9500, respectively. Conclusion: The Xiantao Zhong Yi and Makrite FFRs do not adapt adequately to the face of Peruvian HCWs, most having fit factors less than 50.
A escrita e a leitura infantil: efeitos do outro/Outro na travessia da criança pela aquisição da linguagem escrita
Authors: Carvalho Magda Wacemberg Pereira Lima
Published: June 2023

Pretendemos, neste trabalho, colocar em discussão a escrita e a leitura infantil, recortando-se o efeito do outro (alteridade) e do Outro (alteridade radical) na travessia da criança pela aquisição da linguagem escrita. Nesse sentido, este estudo filia-se ao interacionismo em aquisição de linguagem, conforme proposição da pesquisadora brasileira Cláudia de Lemos, que, fundamentada na linguística estruturalista de base europeia e na psicanálise lacaniana, concebe a aquisição de linguagem como consequente à mudança de posição da criança em relação ao outro, à língua e à própria criança. Nesse enfoque, nosso corpus é composto por textos escritos e lidos, em ambiente escolar, por três crianças, entre três e cinco anos de idade, matriculadas no primeiro, segundo e terceiro ano da Educação Infantil. Os dados apontaram que o efeito do outro é o de espelho em que a criança, referida ao texto-discurso desse outro, tenta constituir sua escrita e sua leitura, enquanto o efeito do Outro só é possível a partir da imersão da criança na materialidade dos textos.
Aquisição fonológica: descrição dos dados de fala de crianças com desenvolvimento típico
Authors: Alves Jorge Amanda Rose , Giacchini Vanessa
Published: June 2023

Na aquisição da fonologia típica, observa-se um padrão de desenvolvimento em que a aquisição ocorre de maneira não linear, com regressões de uso, influenciada por fatores biológicos e ambientais. Há poucos estudos sobre essa temática na região Nordeste do Brasil, mais especificamente na cidade de Natal-RN. O objetivo do estudo foi caracterizar a aquisição fonológica típica em crianças residentes na cidade de Natal-RN. Foi coletada a fala de 28 crianças na faixa etária entre 4:1 e 6:5 anos, sem alterações preexistentes. Nas análises contrastiva e por traços distintivos, observou-se que a aquisição de todos os fonemas em ataque simples e ataque complexo estavam presentes, com comportamento semelhante ao observado em estudos como de Lamprecht (2004) e Lazzarotto-Volcão (2012). A realização do arquifonema /R/ em posição de coda medial/final não condiz com o citado em estudos anteriores, em que sugerem que a aquisição desse arquifonema na posição de coda ocorra em torno dos quatro anos antes da estabilização do segmento em ataque complexo. Assim, o perfil de aquisição do arquifonema /R/ não é semelhante ao relatado nos estudos preexistentes.
E, por falar em ciência: resenha crítica de "Como uma língua funciona?", de Luisandro Mendes de Souza
Authors: Alonso Júnior Clóvis Luiz
Published: June 2023

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Subject Index
Authors: Letraria Editora , Editorial Comissão
Published: June 2023

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Impact of dialysate bicarbonate concentration on the progression of coronary artery calcification in patients undergoing haemodialysis: a prospective, interventional study
Authors: Oka Machiko , Ohtake Takayasu , Ishioka Kunihiro , Mochida Yasuhiro , Maesato Kyoko , Moriya Hidekazu , Hidaka Sumi , Kobayashi Shuzo
Published: June 2023

Background This interventional study aimed to assess the relationship between high and low bicarbonate dialysis and quantitatively measure coronary artery calcification (CAC) using multi-slice computed tomography (MSCT) in patients undergoing haemodialysis (HD). Methods We used two dialysates with different bicarbonate concentrations (Kindaly 3E®and Carbostar PⓇ) to evaluate the effects of dialysate bicarbonate concentration on CAC progression. Kindaly 3EⓇwas an acetic-acid dialysate with a dialysate calcium (dCa) concentration of 2.5 mEq/L and a bicarbonate concentration of 25 mmol/L. Carbostar PⓇwas a citric-acid dialysate with a dCa concentration of 3.0 mEq/L and a bicarbonate concentration of 35 mmol/L. The Kindaly 3EⓇdialysate was used for all patients for the first 6 months of the study period, and the Carbostar PⓇdialysate was used for all patients for the second 6 months of the study period. Results Fifty-three patients undergoing HD underwent MSCT at study initiation, whereas 45 underwent follow-up MSCT 6 and 12 months later to evaluate the CAC score (CACS). The serum calcium and phosphorus levels did not change significantly during the study period. Intact parathyroid hormone levels were significantly increased, although both bone alkaline phosphatase and tartrate-resistant acid phosphatase-5b levels were significantly decreased after 6 months of Carbostar P®use. Conclusions Pre-HD bicarbonate levels and CACS changes over a 6-month period (ΔCACS) were significantly higher with Carbostar P®than with Kindaly 3EⓇ. Trial RegistrationThe study was conducted in accordance with the Declaration of Helsinki and approved by the Ethics Committee of Tokushukai Medical Group (TGE01018-008 22/5/2018; TGE-1018-024; 29/11/2018). The University hospital Medical Information Network-Clinical trials registry (UMIN-CTR) number is UMIN000035085 (30/11/2018).
Efficient prediction of milling distortion using inversely-identified inherent strains
Authors: XU YANG , Huang Xiaomei , Chen Yun , Ye Chao , Hou Liang
Published: June 2023

Predictive milling distortion has been widely used to optimize milling design and process. Inherent strains method (ISM) applies plastic strains calculated from small-scale thermo-mechanical simulations to large-scale models to assess residual deformation in less time. In this paper, ISM is proved feasible in milling process by theoretical and experimental analysis. Moreover, a novel method called inverse identification is proposed to obtain milling inherent strain efficiently. To verify the proposed method, two milling cases are presented to evaluate its accuracy in distortion prediction. In addition, comparisons with the thermo-mechanical model and traditional ISM model indicate that the inversely-identified inherent strains can significantly reduce the simulation time at the premise of similar precision, which is practical to be applied in industrial applications.
Distinct Local and Global Functions of Aβ Low-Threshold Mechanoreceptors in Mechanical Pain Transmission
Authors: Gautam Mayank , Yamada Akihiro , Yamada Ayaka , Wu Qinxue , Kridsada Kim , Ling Jennifer , Yu Huasheng , Dong Peter , Ma Minghong , Gu Jianguo , Luo Wenqin
Published: June 2023

The roles of Aβ low-threshold mechanoreceptors (LTMRs) in transmitting mechanical hyperalgesia and in alleviating chronic pain have been of great interest but remain contentious. Here we utilized intersectional genetic tools, optogenetics, and high-speed imaging to specifically examine functions of SplitCre labeled Aβ-LTMRs in this regard. Genetic ablation of SplitCre-Aβ-LTMRs increased mechanical pain but not thermosensation in both acute and chronic inflammatory pain conditions, indicating their modality-specific role in gating mechanical pain transmission. Local optogenetic activation of SplitCre-Aβ-LTMRs triggered nociception after tissue inflammation, whereas their broad activation at the dorsal column still alleviated mechanical hypersensitivity of chronic inflammation. Taking all data into consideration, we propose a new model, in which Aβ-LTMRs play distinctive local and global roles in transmitting and alleviating mechanical hyperalgesia of chronic pain, respectively. Our model suggests a new strategy of global activation plus local inhibition of Aβ-LTMRs for treating mechanical hyperalgesia.
The Alzheimer’s disease risk gene BIN1 regulates activity-dependent gene expression in human-induced glutamatergic neurons
Authors: Saha Orthis , de Farias Ana Melo , Pelletier Alexandre , Siedlecki-Wullich Dolores , Landeria Bruna , Gadaut Johanna , Carrier Arnaud , Vreulx Anaïs-Camille , Guyot Karine , Bonnefond Amélie , Amouyel Philippe , Kilinc Devrim , Queiroz Cláudio , Delahaye Fabien , Lambert Jean-Charles , Costa Marcos
Published: June 2023

Bridging Integrator 1 (BIN1) is the second most important Alzheimer’s disease (AD) risk gene, but its physiological roles in neurons and its contribution to brain pathology remain largely elusive. In this work, we show that BIN1 plays a critical role in the regulation of calcium homeostasis, electrical activity, and gene expression of glutamatergic neurons. Using single-cell RNA-sequencing of cerebral organoids generated from isogenic BIN1 wild-type (WT), heterozygous (HET) and homozygous knockout (KO) human-induced pluripotent stem cells (hiPSCs), we show that BIN1 is mainly expressed by oligodendrocytes and glutamatergic neurons, like in the human brain. Both HET and KO cerebral organoids show specific transcriptional alterations, mainly associated with ion transport and synapses in glutamatergic neurons. We then demonstrate that BIN1 cell-autonomously regulates gene expression in glutamatergic neurons by using a novel protocol to generate pure culture of human-derived induced neurons (hiNs). Using this system, we also show that BIN1 plays a key role in the regulation of neuronal calcium transients and electrical activity via its interaction with the L-type voltage-gated calcium channel Cav1.2. BIN1 KO hiNs show reduced activity-dependent internalization and higher Cav1.2 expression compared to WT hiNs. Pharmacological blocking of this channel with clinically relevant doses of nifedipine, a calcium channel blocker, partly rescues neuronal electrical and gene expression alterations in BIN1 KO glutamatergic neurons. Further, we show that transcriptional alterations in BIN1 KO hiNs affecting biological processes related to calcium homeostasis are also present in glutamatergic neurons of the human brain at late stages of AD pathology. Together, these findings suggest that BIN1-dependent alterations in neuronal properties could contribute to AD pathophysiology and that treatment with low doses of clinically approved calcium blockers should be considered as an option to dampen disease onset and progression.
The Relationship between the Gut Microbiome and Resistance Training: A Rapid Review
Authors: Wagner Adam , Kapounková Kateřina , Struhár Ivan
Published: June 2023

The human gut microbiome is attracting increasing attention because of its overall effect on human health. A number of reviews have explored the effect of physical activity on the gut microbiome, though these have mostly focused only on endurance or combined types of physical activity. This study aims to describe the effect of resistance or strength training on the gut microbiome of a healthy or unhealthy population. This rapid review follows the guidelines of the Cochrane Rapid Reviews Guidance along with PRISMA. A review of the literature was carried out using articles indexed by PubMed, Scopus, and Web of Science published in the last 12 years. None of the seven studies included find significant change in the gut microbiome in terms of bacterial taxa composition or overall diversity, though the results show that resistance training might decrease the zonulin level and increase mucin production and thereby reduce inflammation in the gut. Interestingly, two studies point to a gut-muscle axis connection and this is discussed in our paper. However, due to the small number of existing studies and certain methodological disagreements, it was hard to find a consensus on the relationship between the gut microbiome and resistance training.
Psychometric Evaluation of the Chinese Version of the Multidimensional Competitive Orientation Inventory
Authors: Wang Yuqian , Orosz Gabor , Chen Xi , Miao Chengguo , Li Yansong
Published: June 2023

This study examined the psychometric properties of the Chinese version of the Multidimensional Competitive Orientation Inventory (Ch-MCOI) in adults from Mainland China. A total of 1121 participants (50.6% male; M = 28.86, SD = 8.70) were recruited for this study. All participants completed the Chinese versions of the MCOI, the Connor-Davidson Resilience Scale (CD-RISC), the Warwick-Edinburgh Mental Well-being Scale (WEMWBS), the Almost Perfect Scale-Revised (APS), and the Frost Multidimensional Perfectionism Scale (MPS-f). A subsample of 239 participants (50.6% male; M = 32.04, SD = 8.13) completed the Ch-MCOI again after a two-week interval to assess test–retest reliability. Exploratory Structural Equation Modeling (ESEM) yielded a four-factor structure (hyper-competitive orientation, self-developmental competitive orientation, anxiety-driven competition avoidance, and lack of interest toward competition), which was further validated by confirmatory factor analyses with a satisfactory fit. Furthermore, test–retest reliability, internal consistency, and concurrent validity were also acceptable. Our findings suggest that the Ch-MCOI could be a reliable and valid instrument for assessing the adaptive and maladaptive facets of competitive orientations in the Chinese-speaking population.
Efficacy of Copper Nanoparticles Encapsulated in Soya Lecithin Liposomes in Treating Breast Cancer Cells (MCF-7) In Vitro
Authors: Ahmed Shaimaa A. , Gaber Mohamed H. , Salama Aida A. , Ali Said A.
Published: June 2023

Cancer is one of the leading causes of death which attracted the attention of the scientific world to search for efficient methods for treatment. With the great development and regeneration of nanotechnology over the last 25 years, various nanoparticles in different structures, shapes and composites provide good potential for cancer therapy. The purpose of this study aims to investigate the effect of Copper nanoparticles (CuNPs) as a drug model for cancer treatment either in their free form or encapsulated in Soy lecithin liposomes (SLP) from plant origin as a cheap source of lipids. CuNPs were by the chemical reduction method then loaded to SLP through the thin film hydration method. The drug model Cu/SLP was successfully combined. The characteristics of the free CuNPs, liposomes, and the combined form, zeta potential, size distribution, drug encapsulation efficiency (EE%), drug release profile, Fourier transform Infrared (FTIR), transmission electron microscopy (TEM) were checked followed by in vitro study on breast cancer cell line Mcf-7 as a model for cytotoxicity evaluation. The optimal Cu/SLP had a particle mean size of 81.59 ± 14.93 nm, a negative zeta potential of -50.7 ± 4.34 mV, the loaded CuNPs showed EE% of 78.9%, and a drug release profile for about 50% of the drug was released after 6 h, and FTIR analysis are recorded. The cytotoxicity assay showed that the IC50 of Cu/SLP is smaller than that of free CuNPs. These results give clear evidence of the efficacy of using the combined Cu/SLP than CuNPs alone as a model drug carrier prepared from plant origin against cancer medically and economically.
A Mutual Authentication Quantum Key Agreement protocol based on Bell Pair
Authors: Rao B. Devendar , Jayaraman Ramkumar
Published: June 2023

Identification and key negotiation between trusted users play a pivot role in generating a session key. The existing protocol uses quantum resources with memory for authentication process but the storage time for qubit is limited. A new mutual authentication quantum key agreement protocol was proposed using Bell pair and the pre-shared key act as the basis for applying bell state measurement without storing the qubit. Security of the proposed protocol depends on inappropriate applying the Bell measurement in different basis leading to entanglement swapping. The participant is able to create a fair session key for each communication and mutually authenticate each identity. The key negotiation and authentication phases of the proposed mutual authentication quantum key agreement protocol have demonstrated that it is unconditional secure.
Uncoupling of lifespan and reproductive tradeoffs by dietary methionine and one-carbon metabolism
Authors: Wei Fangchao , Liu Shiyu , Liu Juan , Allen Annamarie , Reid Michael , Locasale Jason
Published: June 2023

Aging has been proposed to be a consequence of reproductive ability and longevity thus occurs as a tradeoff with organismal reproduction1, 2. Lifespan extending interventions generally at the expense of fertility3. How this principle extends to nutrition and metabolism is not understood. We considered dietary methionine restriction (MR) that is linked to one carbon metabolism as well as to Mediterranean or plant-based diets4 ,5 and known to influence cancer6, metabolic health7, and longevity3, 8. Using a chemically defined diet (CDD) we developed for Drosophila melanogaster, we found that MR-mediated lifespan extension indeed occurs at the expense of reproduction. A survey of the nutritional landscape in the background of MR revealed that folic acid, a vitamin linked to one carbon metabolism, surprisingly was the lone nutrient that restored reproductive defects without compromising lifespan extension. In vivo isotope tracing, metabolomics and flux analysis identified the Tricarboxylic (TCA) cycle and redox coupling as the primary determinants of MR benefits. Interestingly, the fecundity defect occurred through altered sperm function and its restoration by folic acid supplementation also restored sperm mitochondrial metabolism. Together these findings suggest that dietary interventions connected to specific changes in metabolism can separate adverse effects that may occur by enhancing longevity.
A survey of diet, exercise and psychological changes in cancer survivors before and after suffering from cancer
Authors: Qiu Li , Zhang Junfeng , Li Chenchen , He Wen , Yin Xuelian , Zhan Lin , Wang Yanli
Published: June 2023

Background: Cancer treatment is a long and arduous process. In order to promote cancer recovery, cancer patients will adjust and improve their diet, exercise and mental state according to their recovery.
Objectives: This article aimed to understand the changes in the diet, exercise and psychological of cancer survivors.
Methods: This study carried out the research by distributing the electronic questionnaire and carried out the statistical analysis.
Results: In terms of diet, the patients' diet taste became light; In terms of exercise, the number of hours of exercise per week increased significantly among cancer survivors, and people's exercise styles became more diversified. After cancer, survivors were able to better control mood swings and reduce negative emotions.
Conclusion: In the process of treatment and rehabilitation, survivors will pay more attention to the balanced combination of diet and nutrition, improve the way of exercise, at the same time, they also pay attention to adjust their mental state to promote the recovery of cancer.
A recommendation algorithm based on fullink consistency optimization
Authors: Lu Wenjie
Published: June 2023

Recommendation systems have evolved into multi-purpose and modular developments. Due to the complexity of the recommendation pipeline, this inevitably leads to inconsistent goals among the modules and the overall pipeline. To improve the consistency of the recommendation systems pipeline, we propose a knowledge-based learning framework for full pipeline consistency (COKA). This is the first work to combine knowledge graphs and apply them to the full recommendation pipeline.First, in order to enhance the precision of the ranking model with the highest accuracy in the recommendation pipeline, we introduce the user's historical comments and use the Named Entity Recognition (NER) system to identify and combine entity linking (EL). The system maps the identified entities in the first step to the corresponding entities in Wikipedia.Next, we construct a subgraph that depends on the extracted entities and related entities. Here we use GCN[1] to represent the contextual information of the subgraph. On this basis, we introduce the infonce loss[2] of contrastive learning to help the model further identify the metric expression of the sample. At the same time, in constructing the sample stream of contrastive learning, we introduce a global extra queue in addition to the batch simple[3] to further help alleviate the SSB[4] problem.Finally, we learn the final ranking of the precision ranking through a small dual-tower and bring the expression of the precision ranking model into the entire pipeline through a simple structure to enhance the overall consistency of the recommendation pipeline.
Autonomic function effects on postoperative sleep disorder: a prospective cohort study
Authors: Fang Yunda , Wang Gang , Kan Mingyun , Liu Fengming , Wei Chen , Deng Zhengming , Jiang Zhiwei
Published: June 2023

Background
Early non-invasive identification of patients at risk of developing postoperative sleep disorder (PSD), which is common after surgery, is an essential step in reducing surgery stress and an important part of enhanced recovery after surgery.
Objective
We used smart HRV patches to (1) explore different HRV parameters as potential PSD biomarkers and (2) develop and validate a prognostic model for the early prediction of PSD including change of autonomic function in early postoperative period.
Methods
This is a prospective cohort study where we assessed autonomic function in a separate sample of 51 patients who underwent DaVinci robotic/laparoscopic radical surgery for gastrointestinal cancer with and without insomnia.
Results
In this study, 22(43.137%) of 51 patients experienced PSD. Multivariate logistic regression analysis showed that ICU, POD3 nocturnal LF/HF and SD daytime pNN50 were risk predictors of postoperative sleep quality. The risk factor prediction model was established using ICU (P = 0.013, OR = 0.030), 120h SDNN (P = 0.072, OR = 0.954), POD3 daytime LF/HF (P = 0.096, OR = 3.894), POD3 nocturnal LF/HF (P = 0.025, OR = 1.235), POD2 24h LF/HF (P = 0.256, OR = 4.370), and SD daytime pNN50 (P = 0.039, OR = 0.828). The AUC was 0.969.
Conclusion
Circadian rhythm and activity of ANS was involved in PSD. HRV based on remote measurement technology and long-range monitor have potential as digital biomarkers for helping predict PSD.
Preventing Data Leakage in Cloud Servers through Watermarking and Encryption Techniques
Authors: Devi B. Padmini , Kannadhasan S.
Published: June 2023

Due to the increasing utilization of various systems, services, and applications, sharing multimedia data has become a vital component of individuals' daily routines. However, data leakage is a common problem in cloud storage systems, which poses a significant threat to the confidentiality and copyright protection of multimedia information. To address this issue, digital watermarking has been suggested as an effective method for protecting copyright. The recommended approach combines watermarking and Proxy Re- (PRE) to ensure secure multimedia material exchange. Encryption techniques are also used to protect data from unauthorized access. The proposed method includes encrypting a secret key with a certain key, then combining it with encrypted key data, and ultimately embedding it into an image via the Least Significant Bit (LSB) technique. Once the sensitive information is inserted, the image can be encoded using the ECC Encryption method.Built-in data to the verification method allows authenticated individuals to recover the decryption key, which can identify unauthorized access and restrict content redistribution. The proposed application has the potential to prevent unauthorized access in cloud environments and ensure the security of sharing multimedia data.
Nurses’ knowledge and attitudes about adult post-operative pain assessment and management: cross sectional study in Qatar
Authors: Samara Haya , O’Hara Lily , Singh Kalpana
Published: June 2023

Aim To assess the knowledge and attitudes of nurses in Qatar about adult post-operative patients’ pain assessment and management, and the factors that may be associated with such knowledge and attitudes. Background Pain is a complex and challenging phenomenon. People have different pain experiences but everyone has the right to effective pain management. Pain assessment and management are integral components of a nurse’s role. Methods Post-operative registered nurses from all perioperative areas at Hamad Medical Corporation participated in a cross-sectional online survey using a self-administered questionnaire. A knowledge and attitudes (K&A) score was calculated. Associations between K&A and potential explanatory variables were assessed using t tests and one-way ANOVA. Results A total of 151 post-operative nurses participated in the study (100% response rate). The mean knowledge and attitudes (K&A) score was 19.6 ± 4.5 out of 41 (48%), indicating a large deficit in nurses’ knowledge and attitudes about adult post-operative pain. There were no statistically significant differences in the mean K&A scores of participants based on gender, nationality, education level, marital status, workplace facility, current job designation, or hours of pain education. Conclusion There is a significant deficit in post-operative nurses’ knowledge and attitudes about pain across the nursing workforce in post-operative care. Implications for nursing education and policy: Evidence-based, innovative nursing education courses are needed to improve nurses’ knowledge and attitudes about pain assessment and management. Health service policy is required to ensure that evidence-based in-service education on pain management is compulsory for all nurses.
Incidence and risk factors of proximal junctional kyphosis in adolescent idiopathic scoliosis after correction surgery: a meta-analysis and systematic review
Authors: Ji XingHua , Wei LinDong , Xing ZeJun , Duan YuChen
Published: June 2023

Aim
To analyze the risk factors of proximal junctional kyphosis (PJK) after correction surgery in patients with adolescent idiopathic scoliosis (AIS).
Methods
PubMed, Medline, Embase, Cochrane Library, Web of Science, CNKI, and EMCC databases were searched for retrospective studies utilizing all AIS patients with PJK after corrective surgery to collect preoperative, postoperative, and follow-up imaging parameters, including thoracic kyphosis (TK), lumbar lordosis (LL), proximal junctional angle (PJA), the sagittal vertical axis (SVA), pelvic incidence (PI), pelvic tilt (PT), pelvic incidence-lumbar lordosis (PI-LL), sacral slope (SS), rod contour angle (RCA) and upper instrumented vertebra (UIV).
Results
Nineteen retrospective studies were included in this meta-analysis, including 550 patients in the intervention group and 3456 patients in the control group. Overall, sex (OR 1.34, 95% CI (1.03,1.76), P = 0.03), larger preoperative TK(WMD 6.82, 95% CI (5.48,8.16), P＜0.00001), larger follow-up TK(WMD 8.96, 95% CI (5.62,12.30), P＜0.00001), larger postoperative LL(WMD 2.31, 95% CI (0.91,3.71), P = 0.001), larger follow-up LL(WMD 2.51, 95% CI (1.19,3.84), P = 0.0002), great change in LL(WMD − 2.72, 95% CI (-4.69,-0.76), P = 0.006), larger postoperative PJA(WMD 4.94, 95% CI (3.62,6.26), P＜0.00001), larger follow-up PJA(WMD 13.39, 95% CI (11.09,15.69), P＜0.00001), larger postoperative PI-LL (WMD − 9.57, 95% CI (-17.42,-1.71), P = 0.02), larger follow-up PI-LL(WMD − 12.62, 95% CI (-17.62,-7.62), P＜0.00001), larger preoperative SVA(WMD 0.73, 95% CI (0.26,1.19), P = 0.002), larger preoperative SS(WMD − 3.43, 95% CI (-4.71,-2.14), P＜0.00001), RCA(WMD 1.66, 95% CI (0.48,2.84), P = 0.006) were identified as risk factors for PJK in patients with AIS.
Conclusion
The incidence of PJK in patients with AIS was 19%. Sex, larger preoperative TK, larger follow-up TK, larger postoperative LL, larger follow-up LL, great LL change, larger postoperative PJA, larger follow-up PJA, larger postoperative PI-LL, larger follow-up PI-LL, larger preoperative SVA, larger preoperative SS and RCA were identified as risk factors for PJK in AIS post-correction surgery.
Utilization of [Ga68]FAPI PET/CT in the Evaluation of Thyroid Nodules with 'Suspected' or ‘Malignant’ FNAB: Preliminary Results
Authors: Elboga Umut , Maralcan Gokturk , Bastemir Mehmet , Sahin Ertan , Okuyan Merve , Sokucu Mehmet , Mutlu Melis , Cayirli Yusuf Burak , Celen Yusuf Zeki
Published: June 2023

OBJECTIVE: Fine needle aspiration biopsy (FNAB) is the standard diagnostic approach for identifying thyroid cancer. However, there are challenges with FNAB, such as its invasiveness and the need for repeat procedures based on suspected cytology results. Stroma-targeted PET imaging, using 68Ga-FAPI PET/CT, has shown promising results in detecting tumors and may be a less invasive tool to differentiate between malignant and indeterminate thyroid nodules.
METHODS: This prospective registry study included twenty two patients with tweny four nodules. 68Ga-FAPI PET/CT was performed after fine needle aspiration biopsy (FNAB). Any non-physiological uptake greater than adjacent normal tissue background on 68Ga-FAPI PET/CT was included in the study. The TBR (tumor to background ratio) was defined as the ratio of the lesions’ SUVmax and the SUVmax of healthy thyroid parenchyma tissue determined for each reconstruction algorithm. All the patients had undergone thyroidectomy to confirm the results of FNAB. The post operation histological specimen were also taken as the reference standard. Post-op histopathology, FNAB results and TBR values on 68Ga-FAPI FAPI PET/CT were compared.
RESULT: The study found that malignant thyroid nodules had significantly higher mean SUVmax values compared to benign nodules. However, there was no significant difference in activity uptake between the backgrounds of the nodules. The tumor-to-background ratio (TBR) was higher in malignant nodules, although statistical significance was not reached. Non-follicular types of malignant nodules exhibited significantly higher SUVmax and TBR values compared to follicular variants and benign nodules. There was no significant difference in activity uptake in the backgrounds. Non-follicular types consistently showed higher SUVmax and TBR values, while follicular variants did not display significant activity uptake compared to benign nodules.
CONCLUSION: Due to highly significant SUVmax correlation between benign nodules and background, TBR could be more reliable point of reference in evaluation of thyroid nodules. Non-follicular types of PTC showed significantly higher SUVmax values and prominent TBR compared to follicular variants and benign nodules. After re-categorization, 68Ga-FAPI PET/CT showed 100% sensitivity and NPV in detection of non-follicular types of PTC.