bluuebunny/crossref_metadata_2025 huggingface dataset:
DAMPAK SOSIAL DAN EKONOMI PENGEMBANGAN GEOWISATA KAWAH CIWIDEY TERHADAP KEHIDUPAN MASYARAKAT LOKAL
Authors: Suherman Mayang Putri , Dagsa Ratri Dara , Asyari Nia Fitri , Kamilin Muhammad Furqon , Nuzula Ulinda Firdausi , Prasetyo Ridzal , Aprilianto Bayu Dwi , Noviantoro Kurnia Maulidi
Published: February 2025

This study aims to assess the social and economic impacts of geotourism development of Ciwidey White Crater on local communities. The research method used is descriptive qualitative with data collection through observation, interviews, and documentation studies. The results of this study indicate that the development of Kawa Putih geotourism has had a positive impact on the economy of the surrounding community through increased income and employment. However, on the other hand, there are potential negative impacts such as environmental damage and socio-cultural changes. To overcome these challenges, sustainable geotourism management is needed by involving local communities, as well as the development of infrastructure and facilities that support tourism. This research concludes that the development of Kawah Putih geotourism has great potential to improve the welfare of the community, but it needs careful planning and involves various related parties.
ABSTRAK
Penelitian ini bertujuan untuk menilai dampak sosial dan ekonomi dari pengembangan geowisata Kawah Putih Ciwidey terhadap masyarakat lokal. Metode penelitian yang digunakan adalah deskriptif kualitatif dengan pengumpulan data melalui observasi, wawancara, dan studi dokumentasi. Hasil penelitian ini menunjukkan bahwa pengembangan geowisata Kawa Putih memberikan dampak positif bagi perekonomian masyarakat sekitar melalui peningkatan pendapatan dan penyerapan tenaga kerja. Namun, di sisi lain, terdapat potensi dampak negatif seperti kerusakan lingkungan dan perubahan sosial budaya. Untuk mengatasi tantangan tersebut, diperlukan pengelolaan geowisata yang berkelanjutan dengan melibatkan masyarakat lokal, serta pengembangan infrastruktur dan fasilitas pendukung pariwisata. Penelitian ini menyimpulkan bahwa pengembangan geowisata Kawah Putih memiliki potensi yang besar untuk meningkatkan kesejahteraan masyarakat, namun perlu perencanaan yang matang dan melibatkan berbagai pihak terkait.
INOVASI GURU IPS DALAM MENINGKATKAN MINAT BELAJAR SISWA DI SMP NEGERI 2 PACIRAN
Authors: Yoga Wildan Mahya
Published: February 2025

Teachers have an important responsibility in understanding learners' interests through their skills, including in choosing the right learning model that directly affects the success of the learning process. By applying innovation, teachers can increase the attractiveness, interactivity and effectiveness of learning, so it is recommended to integrate innovation in their learning practices. This research aims to describe the way social studies is taught at SMP Negeri 2 Paciran and to explore the innovations applied by social studies teachers to increase students' interest in learning. The research method used is qualitative with a descriptive approach, involving research subjects such as the principal, vice chairman of the curriculum, social studies teacher of class VII, and students of class VII F. Data were obtained through observation, interviews, and documentation, then analyzed based on the theory of Miles, Huberman, and Saldana which includes data condensation, data presentation, and conclusion drawing. The results showed that social studies teachers succeeded in creating a pleasant learning environment, integrating theory with facts, and using diverse media according to student needs, as well as implementing innovations in the form of puppet media to enrich learning and increase student interest and involvement in the learning process.
ABSTRAK
Guru memiliki tanggung jawab penting dalam memahami minat peserta didik melalui keterampilan yang dimiliki, termasuk dalam memilih model pembelajaran yang tepat yang secara langsung mempengaruhi keberhasilan proses pembelajaran. Dengan menerapkan inovasi, guru dapat meningkatkan daya tarik, interaktivitas, dan efektivitas pembelajaran, sehingga disarankan untuk mengintegrasikan inovasi dalam praktik pembelajaran mereka. Penelitian ini bertujuan untuk menggambarkan cara pengajaran IPS di SMP Negeri 2 Paciran dan untuk mengeksplorasi inovasi yang diterapkan oleh guru IPS untuk meningkatkan minat belajar siswa. Metode penelitian yang digunakan adalah kualitatif dengan pendekatan deskriptif, melibatkan subjek penelitian seperti kepala sekolah, wakil ketua kurikulum, guru IPS kelas VII, dan siswa kelas VII F. Data diperoleh melalui observasi, wawancara, dan dokumentasi, kemudian dianalisis berdasarkan teori Miles, Huberman, dan Saldana yang meliputi kondensasi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa guru IPS berhasil menciptakan lingkungan pembelajaran yang menyenangkan, mengintegrasikan teori dengan fakta, dan menggunakan media beragam sesuai dengan kebutuhan siswa, serta mengimplementasikan inovasi berupa media pewayangan untuk memperkaya pembelajaran dan meningkatkan minat serta keterlibatan siswa dalam proses belajar.
Mental Health Symptoms and Substance Use After Recent Sexual Assault Based on Sexual Orientation
Authors: Salim Selime R. , Tilstra-Ferrell Emily L. , Mai Katherine , Rheingold Alyssa , Gilmore Amanda K. , Hahn Christine K.
Published: February 2025

The current study examined differences in acute stress and depression symptoms, alcohol use, and drug use between sexual minority and heterosexual survivors in the weeks following a sexual assault. The sample included 26 sexual minority and 66 heterosexual survivors (N= 92, 94.4% cisgender women, 51.1% White, and 31.5% Black) who completed screening during a follow-up mental health service after receiving a sexual assault medical forensic examination. Group differences on brief mental health and substance use screening measures were examined using χ2tests andttests. Sexual minority survivors reported higher acute stress symptoms and were more likely to report drug use in the past 2 weeks, but no differences in depression symptoms and alcohol use were found. Results highlight the need for increased research on sexual minority survivors’ unique experiences and needs following recent sexual assault.
“Un cuento que no acaba”. Agripina Samper de Ancízar e Inés Ancízar Samper. Obras (1848- 1892). Edición, introducción y notas de Carolina Alzate. Bogotá: Universidad Nacional de Colombia, 2024 (Obras Escogidas). 440 pp.
Authors:   Universidad de los Andes, Pérez Peñaloza María Angélica
Published: February 2025

Mucho se ha debatido y escrito sobre el espacio —o la falta de este— que ocupan las mujeres en la literatura, en el relato de la historia o en el arte. Sin embargo, todavía resulta sorprendente que autoras tan agudas, tan sensibles a su entorno y tan preo-cupadas por la creación de una nación vean la luz casi ciento veinte años después de haber escrito sus piezas literarias. Tal es el caso de Agripina Samper de Ancízar e Inés Ancízar Samper, autoras de las obras reunidas en este libro, el cual nos lleva por los poemas, las disputas lingüísticas, las cartas y el diario íntimo de dos mujeres, madre e hija, que fueron asediadas y exiliadas por el poder conservador de su época. La pri-mera, una prolífica poeta conocida en la prensa, casada con un hombre abierta y de-cididamente liberal, Manuel Ancízar, cuya publicación La peregrinación de Alpha reposa en la misma colección donde acaba de ser publicado el de su esposa y su hija. Y la segunda, hija de estos dos personajes, autora de un diario íntimo donde cuenta acerca de su vida en Bogotá dos años después de la muerte de su padre y de la decisión de salir de Colombia —junto con su madre— rumbo a Francia, pues eran perseguidas por la élite conservadora debido a su postura política
Concentração de mercado e o perfil da oferta de educação superior
Authors: Zucarelli Carolina , Padilha André de Holanda Oliveira , Mendonça Lara dos Santos
Published: February 2025

O sistema de educação superior brasileiro passou por um extenso processo de reconfiguração estrutural nas últimas décadas. Como fruto de movimentos multifacetados de financeirização, oligopolização e internacionalização, o mercado privado passou a se organizar em torno de sete grupos empresariais de capital aberto que, apesar de representarem apenas uma em cada dez instituições de ensino superior, respondiam, juntos, por quase metade das matrículas da rede privada em 2022. Este artigo tem como objetivo investigar os efeitos da concentração de mercado para o perfil da oferta educacional, destacando as transformações organizacionais e os instrumentos financeiros que sustentam o fenômeno. Os resultados mostram que, em razão da influência dos oligopólios nas políticas educacionais e de seu significativo crescimento ao longo da última década, há uma forte tendência de que o sistema de ensino no Brasil seja dominado por cursos na modalidade a distância, fortemente concentrados em poucas instituições de ensino.
Training in Designing Mathematics Learning Using Local Context of Wetland Environment Based on Realistic Mathematics Education (RME)
Authors: Pasani Chairil Faif , Hidayanto Taufiq , Kamaliyah Kamaliyah , Ridha Muhammad Taqwa , Daris Muhammad
Published: February 2025

The problem in several schools is that students experience learning loss due to the COVID-19 pandemic, so several generations of students are slowly learning. Apart from that, the 2022 AKM results are less than optimal because not all students are familiar with contextual problems. Therefore, training in designing mathematics learning using the local context of the wetland environment based on RME needs to be implemented. This service aims to develop the ability of teachers of SDI Sabilal Muhtadin to design mathematics learning using the local context of the wetland environment based on RME to increase teachers' understanding and ability to design realistic learning. The method applied in this community service activity uses a PAR (Participatory Action Research) approach. The PAR cycle implemented is To Know, To Understand, To Plan, To Act, and To Change. The service team prepares material and delivers it via an offline workshop, while participants are also allowed to design learning with a local context and based on RME. The service results show an increase in teacher understanding regarding RME-based learning designs in the local context of the wetland environment, which is indicated by an increase in the average score from pre-test to post-test. Apart from that, most teachers have been able to develop mathematics learning plans based on RME in a local context. This is shown by the teacher's work in designing lessons sent to the service team. Thus, this service activity has successfully increased teachers' understanding and abilities in designing realistic learning.
Physical Fitness Gymnastics Training for Improving the Quality of Physical Education Student
Authors: Nova Andi , Syahputra Muhajjir , Fitria Fitria , Surimeirian M Anas , Roberto Julio , M Benny Aprial , Nofrizal Dedi , Tantri Afri , Zati Muhammad Rizqi
Published: February 2025

Increasing the competence of graduates is one of the Merdeka campus programs contained in key performance indicators 1 and 2, namely obtaining decent work and experience outside the campus. Preparing the competence of graduates, the Physical Education study program conducts physical fitness gymnastics training in collaboration with the Aceh Provincial Dispora. The activity was carried out for three days at the Multipurpose Building of Universitas Samudra, from February 1 to 3, 2024. The method of implementing activities uses participatory Action Research (PAR) with five stages: Planning, Implementation, Analysis, Action, and Sustainability. Activities include initial tests, material submission, practice tests, evaluations, and recommendations. There were 30 participants in physical education at FKIP Universitas Samudra semester IV. The assessment results of the guide resource persons showed that 13 categories were excellent, 14 were good, and three were in the sufficient category. Participants with good categories totalling 13 people are recommended to become trainers in campus environments, gymnastics studios in Langsa City, and government and private institutions.
Integration of Historical Memory of National Minorities in Armenia: the Problem of Shared Historical Trauma
Authors: Dunamalyan N.
Published: February 2025

The article addresses the issue of integrating the memory of national minorities in Armenia. It places significant emphasis on analyzing the development of models of relations between titular ethnic groups and national minorities in the South Caucasus. The author explores the complexity of minority status, considering both legal mechanisms and the transformation of collective historical memory. The study shows how the interweaving of historical memories can influence self-identification of ethnic communities and their interaction with the titular nation. Additionally, the study takes into consideration the legal and ethnographic layers of research in national minorities, proposing to consider the problems of the shared collective memory of various ethnic groups existing in a common political and historical space. Thus, the article traces the historical path of development of ethnic communities in Transcaucasia, demonstrating a gradual demarcation between the ethnic majority and minorities. This aspect not only represents a change in the demographic picture but also draws attention to the formation of inter-ethnic contradictions that underpin the ineffectiveness of historical and partly modern models of identity politics in Georgia, Azerbaijan, and Armenia. Modern approaches to the integration of national minorities in the South Caucasus are illustrated through the examples of the Georgian model of civil-political inclusion of national minorities and the Azerbaijani policy of “limited” multi-ethnicity, tied to loyalty to the ruling regime. However, Armenia in this context appears as a unique example of the “spontaneous” formation of a shared historical memory among the Armenian majority and basic national minorities, with a common historical trauma that has become “timeless” in its nature. The integration of the historical national minorities’ memory in Armenia remains an important aspect of the identity politics within the framework of the modern systemic crisis in the republic.
La guitarra flamenca, un estudio en profundidad sobre la viabilidad de su conversión en un instrumento virtual
Authors:   , Santos Bengoechea Jagoba
Published: February 2025

This research work attempts to study the feasibility of converting a flamenco guitar into a virtual instrument, specifically through the development of a sample pack and the planning of a sample library. Despite flamenco being a young art, the flamenco guitar is a complex instrument that is difficult to model, whose sound spreads through the interaction of many of its parts. The timbre of this chordophone instrument is characterized by a strong, cracked and bright sound, with a fast attack in the vibration of the soundboard and a strong presence in the mid-range of frequencies.

Audio synthesis techniques, both digital and analog, have been unable to fully emulate the behavior of the flamenco guitar. Despite the fact that physical modeling offers a potential to take into account for the future, today and due to the point where the technology is, there is a lot of work to be done. For this reason, the sampling technique or sampling will be the one we use for our products. Their development will in turn give us the answer to the starting hypothesis. In the case of success, the main objective of this research work is to license the resulting libraries to the most representative companies in the sector.

RESUMEN

El presente trabajo de investigación trata de estudiar la viabilidad de conversión de una guitarra flamenca en un instrumento virtual, en concreto a través del desarrollo de un sample pack y la planificación de una librería de muestras. A pesar de ser el flamenco un arte joven, la guitarra flamenca es un instrumento complejo y difícil de modelar, cuyo sonido se propaga a través de la interacción de muchas de sus partes. El timbre de este instrumento cordófono se caracteriza por ser un sonido fuerte, rajado y brillante, con un ataque rápido en la vibración de la tapa armónica y una fuerte presencia en el rango medio de frecuencias.

Las técnicas de síntesis de audio, tanto digital como analógicas, han sido incapaces de emular el comportamiento en su totalidad de la guitarra flamenca. A pesar de que el modelado físico ofrezca un potencial a tener en cuenta de cara al futuro, a día de hoy y debido al punto en el que se encuentra la tecnología, hay mucho trabajo por hacer. Por ello, la técnica de muestreo o sampling será la que utilicemos para nuestros productos. El desarrollo de los mismos nos dará a su vez la respuesta a la hipótesis de partida. En el caso de tener éxito, el objetivo principal de este trabajo de investigación es licenciar las librerías resultantes a las compañías más representativas del sector.
La caja mágica : cuerpo y escena
Authors:   , Quesada López Femando
Published: February 2025

Partiendo de una definición del término "teatro" como espacio escénico, la Tesis estudia seis episodios de la relación entre el concepto teatral y el espacio arquitectónico de la representación durante los siglos XIX y XX. El primero se ocupa de Richar Wagner y del espacio de la tragedia wagneriana, la Festspielhaus de Bayreuth, con su magnificación de la escena y de los personajes como "taslación directa a la realidad de la escena del ideal inalcanzable, lejano, grandioso y misterioso" y con un espacio escénico en cuyo centro se encuentra el héroe, el cuerpo, y fuera del cual se encuentra el espectador. El segundo trata de la Ópera de París, de Charles Garnier, un espectáculo en sí misma, una catedral mundana que crea un panorama-una reproducción en miniatura de la vida metropolitana de París, y establece una continuidad completa entre el edificio teatral y el tejido urbano y hace que el espectador sea también y al mismo tiempo actor. En el tercero se estudia la genalogía de la Gesamtkunstwerk a través de la Dresden Opernhaus de Gottfried Semper, un "artefacto de síntesis entre ciudad y sociedad o tecnología y naturaleza" y a la vez foco y fulcro dentro del foro público. El cuarto analiza las actuaciones de Peter Berhrens y Jospe Olbrich en la Colonia de Artistas de Darmstadt, que "basculan entre los dos polos de la aspiración a una totalidad fuerte, cristalina y geométrica -Behrens- y la aspiración a una totalidad débil -Olbrich- que consiste en la acumulación de subjetividades independientes, interiroes, unificadas por un manto ornamental". En el quinto se trata la figura de Adolphe Appia, "teórico teatral, escenógrafo y director de escena que pasa por ser el más importante renovador de la puesta en escena europea del siglo XX", que hará de la construcción de un vacío escénico para la presencia corporal del actor- y del propio espectador- el fundamento de su trabajo.
The effect of low advanced glycation end product diet on bone health and cardio-metabolic parameters in overweight and obese postmenopausal women: study protocol for a randomised controlled trial (AGEs study)
Authors: Jamka Małgorzata , Kurek Szymon , Miśkiewicz-Chotnicka Anna , Krzyżanowska-Jankowska Patrycja , Walkowiak Marek , Bęben Małgorzata , Wichłacz-Trojanowska Natalia , Brylak Jan , Makarewicz-Bukowska Aleksandra , Chrobot Maria , Jaworska Natalia , Popek Joanna , Walkowiak Jarosław
Published: February 2025

Advanced glycation end products (AGEs) have been suggested to play an important role in osteoporosis. However, no randomised controlled trial has investigated the effect of a diet with low AGEs on densitometric parameters. This study will evaluate the effect of a 12-month low AGEs diet on bone health and cardio-metabolic parameters in postmenopausal overweight and obese women. In total, 80 subjects will be included in the study and randomly divided into two groups: low AGEs diet and standard AGEs diet for 12 months. The mineral density and content will be measured at the lumbar spine, femoral neck, and total body during the pre- and post-intervention period. Selected markers of bone formation and resorption will be assessed. Anthropometric parameters and body composition will be evaluated and markers of glucose, insulin, lipid metabolism, inflammatory and endothelial parameters will be measured. Adherence to the diet will be monitored using dietary records.
Botulinum toxin type A in the treatment of laryngeal dystonia: a single-center experience
Authors: Ziarno Remigiusz , Dec-Ćwiek Małgorzata , Sobuś Magdalena , Skórkiewicz Konrad , Grudzień-Ziarno Aleksandra , Składzień Jacek , Tomik Jerzy
Published: February 2025

Aim. The aim of this study was the analysis of the problem of laryngeal dystonia in patients of Otolaryngology and Neurology Clinics to assess the efficiency of effects of Botulin Toxin type A  (BOTOXtm) injections on voice quality and function of vocal cords with the use of videolaryngostroboscopic and laryngographic examinations, GRBAS (G - grade of hoarseness, R - roughness, B - breathiness, A – aesthenia, S -strain)  scale and voice field.
Material and methods. Between 2020 and 2022 a total of 50 patients with laryngeal dystonia were examined. The videolaryngostroboscopic and laryngographic examinations confirmed laryngeal dystonia. Afterwards the patients undertook  Botulinum Toxin type A injections into the thyro-arythenoid muscle.
Results. Control examinations confirmed the improvement of vocal folds movability and the decrease in number of irregular vocal folds vibrations. The next injection of BOTOXtm substance was done 3-6 months after the last injection.
Conclusion. The results of our study suggest that although BOTOXtm toxin still remains the main form of treatment for laryngeal dystonia, using it improves phonatory function of larynx (as proven by videolaryngostroboscopic examination).
Carnitine palmitoyltransferase 1C promotes EMT-associated cisplatin resistance in non-small cell lung cancer cells
Authors: Chen Renjie , Wang Jiahui , Huang Shuoyu , Hu Xuefeng , He Xinran , Zhang Tiange , Hu Yunhan , Wei Huijun , Nian Sihui , Huang Yushu , Wu Zhihao
Published: February 2025

Objective: Lung cancer is the most common cause of cancer-related deaths worldwide. Platinum-based chemotherapy is one of the main treatment options for patients with non-small cell lung cancer (NSCLC) but the effectiveness of chemotherapy is encumbered by drug resistance. Therefore, understanding the molecular mechanisms underlying chemotherapy resistance is crucial in improving treatment outcomes and prognosis. Methods: The cell viability assay and apoptosis were used to analyze chemoresistance. Western blot analysis and wound healing testing were used to evaluate the epithelial-to-mesenchymal transition (EMT). Immunoprecipitation was used for analysis of protein modification. Promoter activity was determined using the luciferase reporter assay. Immunofluorescence staining was used to determine reactive oxygen species levels. The expression patterns of EMT markers and carnitine palmitoyltransferase 1C (CPT1C) were determined by Western blot analysis. Results: CPT1C, which was shown to be highly expressed in lung cancer, is associated with cisplatin resistance in NSCLC cells. CPT1C depletion increased NSCLC cell sensitivity to cisplatin, while overexpression of CPT1C increased NSCLC cell resistance to cisplatin. Induction of EMT mediated CPT1C-induced cisplatin resistance. Ectopic expression of Snail reversed the increase in cisplatin sensitivity triggered by CPT1C knockdown. Moreover, CPT1C was shown to be regulated at the post-translational level and an E3-ubiquitin ligase, NEDD4L, was shown to be a major regulator of CPT1C stability and activity. Conclusions: These data provide evidence for the first time that the lipid metabolism enzyme, CPT1C, mediates resistance to chemotherapy. Therefore, the use of combination therapy with a CPT1C inhibitor may be a promising new avenue in lung cancer treatment.
Clinical significance of cervical biopsy during pregnancy
Authors:   V.I.Krasnopolsky Moscow Regional Research Institute of Obstetrics and Gynecology, Moscow, Russian Federation, Zarochentseva N.V. , Vyzhlova E.N. ,   N.F.Gamaleya National Research Centre for Epidemiology and Microbiology, Moscow, Russian Federation, Barinova I.V. ,   V.I.Krasnopolsky Moscow Regional Research Institute of Obstetrics and Gynecology, Moscow, Russian Federation, Tsikanova D.Z. ,   V.I.Krasnopolsky Moscow Regional Research Institute of Obstetrics and Gynecology, Moscow, Russian Federation, Trishchenkova O.V. ,   V.I.Krasnopolsky Moscow Regional Research Institute of Obstetrics and Gynecology, Moscow, Russian Federation
Published: February 2025

Cervical pre-cancer and cancer remain a major problem in obstetrics and gynecology. These conditions become especially relevant during pregnancy. In the Russian Federation, the incidence of cervical cancer (CC) in pregnant women ranges from 1:2000 to 1:5000, carcinoma in situ – 1:770. Cervical pre-cancer is diagnosed in 1–7% of pregnant patients, among them the prevalence of HSIL (high-grade intraepithelial lesion) is 0.5%. Extended colposcopy during pregnancy is a significant and safe diagnostic method for suspected CC. The indication for cervical biopsy in pregnancy is suspicion of CC based on colposcopy and cytology. Instead of cytological HSIL, it may turn out to be invasive CC since there is no correlation between cytological and histological examinations of the cervix. There is still no consensus on the need for cervical biopsy in pregnant women, especially in HSIL. The morphological examination remains the only diagnostic method, thus, the choice of the correct management tactics for this category of patients is a challenging task, as the detection of CC during pregnancy is an extremely difficult situation. In case of verified HSIL or carcinoma in situ, vaginal delivery is possible. In microinvasive and invasive CC, cesarean section is indicated. After childbirth, all patients with HSIL should undergo a comprehensive examination and treatment.
Key words: cervical biopsy, pregnancy, high-grade squamous intraepithelial lesions, colposcopy, cervical cancer
Fatty acid composition of follicular fluid in assisted reproductive technology protocols depending on body mass index
Authors:   Ott Institute of Obstetrics and Gynecology, Saint-Petersburg, Russian Federation, Ryzhov J.R. , Makhmadalieva M.R. ,   Ott Institute of Obstetrics and Gynecology, Saint-Petersburg, Russian Federation, Komarova E.M. ,   Ott Institute of Obstetrics and Gynecology, Saint-Petersburg, Russian Federation, Lesik E.A. ,   Ott Institute of Obstetrics and Gynecology, Saint-Petersburg, Russian Federation, Tapilskaya N.I. ,   Ott Institute of Obstetrics and Gynecology, Saint-Petersburg, Russian Federation, Gzgzyan A.M. ,   Ott Institute of Obstetrics and Gynecology, Saint-Petersburg, Russian Federation, Bespalova O.N. ,   Ott Institute of Obstetrics and Gynecology, Saint-Petersburg, Russian Federation, Kogan I.Yu. ,   Ott Institute of Obstetrics and Gynecology, Saint-Petersburg, Russian Federation
Published: February 2025

Objective. To determine the correlation between fatty acid (FA) levels in follicular fluid (FF) and outcomes of assisted reproductive technology (ART) programs depending on body mass index (BMI).
Patients and methods. A total of 120 patients with infertility undergoing ART protocols were divided into three groups: normal BMI (group 1; n = 40), overweight (group 2; n = 40), and obesity (group 3; n = 40). FA levels in FF were evaluated by MALDI mass spectrometry.
Results. Pregnant patients in group 2 had lower levels of myristic acid (p = 0.008). Pregnant patients in group 3 had lower levels of stearic acid (p = 0.03) and higher desaturation index (DI) (p < 0.001). In the total cohort, there was no correlation between FA levels and BMI in pregnant patients, whereas in non-pregnant patients, myristic acid levels were positively correlated with BMI (p = 0.009), and oleic acid levels (p = 0.002) and DI (p = 0.02) were negatively correlated with BMI.
Conclusion. The presence of two phenotypes of FA metabolism was established. In patients with the first phenotype, high activity of desaturase was found, which converts lipotoxic saturated FAs into “safe” unsaturated FAs. In such patients, an increase in BMI is not followed by a decrease in the efficacy of ART programs. Patients with the second phenotype were found to have decompensation of FA metabolism and low ART efficacy with increasing BMI.
Key words: fatty acids, ART, obesity, desaturase, follicular fluid, IVF
Family as a factor in counter-marketing of tobacco smoking in the strategy of state policy to ensure the protection of motherhood and childhood.
Authors:   Private institution educational organization of higher education «Medical University «Reaviz», Bolshakova P. N. ,   The Federal State Budgetary Educational Institution of Higher Education «Russian State Social University»
Published: February 2025

The demographic realities of today’s Russia have changed the strategy of state policy to ensure the protection of motherhood and childhood, support for families with children and have defined national development goals for the period up to 2036.
Objective of the study: to study the role of family and environment in counter-marketing of tobacco smoking in the context of the strategy of state policy to ensure the protection of motherhood and childhood.
Material and methods: a one-stage open uncontrolled study with random non-repeated selection of respondents was conducted in the form of an anonymous online survey of students of the Reaviz Medical University and the Russian State Sociological University.
Results and discussion: 535 questionnaires were analyzed. The proportion of smokers in the environment of future doctors is high: from 45.3% they live, and from 53.3% – spend their free time. In the environment of respondents, the proportion of traditional cigarettes decreased from 65% among those living nearby, to 40% among people with whom the respondents spend time. The loyalty of family
members to electronic cigarettes has led to a decrease in the total ban on their use in domestic premises to 8.2% versus 60.8% for traditional cigarettes, and an expansion of their use everywhere to 31% versus 2.7% for cigarettes.
Thus, the family as a factor in counter-marketing of tobacco smoking can become a regulator of the conflict of resources: the profits of producers, the budget-forming component of the tobacco industry and the state’s financial resources in the form of reduced costs for the treatment of patients and a decrease in the loss of reproductive, labor and intellectual resources due to morbidity, disability and premature mortality associated with the consumption of tobacco and NP.
The spread of socially significant diseases in the Kabardino-Balkarian Republic.
Authors:   Kabardino-Balkarian State University named after H. M. Berbekov, Sabanchieva Zh.Kh. , Nalchikova M. T. ,   Kabardino-Balkarian State University named after H. M. Berbekov, Tambiev A. R. ,   Kabardino-Balkarian State University named after H. M. Berbekov, Bzhekshieva I. Z. ,   Kabardino-Balkarian State University named after H. M. Berbekov, Baysultanov M. M. ,   Kabardino-Balkarian State University named after H. M. Berbekov
Published: February 2025

One of the key priorities of the state policy in the field of healthcare is to reduce the incidence of socially significant diseases, improve and introduce methods of prevention, early diagnosis of these diseases, increase the effectiveness of their treatment and rehabilitation. In the
Kabardino-Balkarian Republic (KBR), as a result of the implementation of program measures in the Russian Federation to prevent and combat socially significant diseases in recent years, there has been a tendency to decrease the growth of indicators characterizing the health status of the population for these diseases. In order to maintain the achieved indicators, as well as further develop the organization of medical care for persons suffering from socially significant diseases, the situation in the KBR has been analyzed in the KBR.
The purpose of the study: to analyze the situation in the KBR on socially significant diseases.
Materials and methods. The results of the examination of patients with socially significant diseases for the period from January 2022 to december 2023 hospitalized in the medical institution of the KBR are analyzed.
Results. When analyzing the results of the examination of patients with socially significant diseases, a multidirectional dynamics is observed. Thus, when analyzing the incidence and mortality of tuberculosis, there is a decrease in key indicators in 2023 compared to 2022. However, when analyzing other socially significant diseases such as cardiovascular diseases, HIV infection, diabetes mellitus, oncological diseases, alcoholism, mental and narcotic diseases, there is an increase in 2023. Especially, the increase in cancer incidence compared to 2022 amounted to 4.4 percent.
Conclusions. In order to diagnose socially significant diseases as soon as possible and reduce deaths in the OLS, it is necessary to properly organize the work of the general medical network, namely, to introduce modern methods of etiological diagnosis, to organize consultations of narrow specialists. To improve the work in terms of increasing the effectiveness of preventive work of medical organizations, especially with citizens who are at risk, including personalized accounting and constant dynamic monitoring with preventive measures based on the results of medical examinations, as well as targeted preventive examinations.
Organization of patient examination methods for early diagnosis and verification of leading diseases.
Authors:   Federal State Budgetary Educational Institution of Higher Education «South Ural State Medical University» of the Ministry of Health of the Russian Federation, Vazhenin A.V. , Novikova S. V. ,   Federal State Budgetary Educational Institution of Higher Education «South Ural State Medical University» of the Ministry of Health of the Russian Federation, Tyukov Yu.A. ,   Federal State Budgetary Educational Institution of Higher Education «South Ural State Medical University» of the Ministry of Health of the Russian Federation
Published: February 2025

Purpose of the study is to familiarize primary care physicians with modern methods of early diagnosis and verification of leading malignant neoplasms of the population.
Materials and methods. 41 scientific publications processed by the content analysis method were involved in writing this review.
Results and conclusion. Today we can state that there is a wide list of organizational forms and diagnostic techniques for detecting the malignant process. Leading malignant neoplasms at the present stage of oncology development can be detected by palpation, visualized and even diagnosed by traces of its biochemical activity. The achieved indicators of sensitivity and specificity of the diagnostic methods described in the article emphasize the importance of an integrated approach to the early detection of oncological diseases. Effective organization of diagnostics allows not only to increase the level of detection of malignant neoplasms at early stages, but also significantly
improve the prognosis of treatment, which ultimately leads to a reduction in mortality and improvement of the quality of life of patients.
Thus, the development of diagnostic technologies and organizational forms, increasing their availability and public awareness of the possibilities of early diagnosis are key factors in the fight against cancer.
The influence of the dynamics of the cost of drugs for the treatment of patients with broncho-obstructive diseases on the availability of drug treatment in the Russian Federation.
Authors:   Federal Scientific State Budgetary Institution «N. A. Semashko National Research Institute of Public Health», Linnik S. A. ,   Non-government organization «Scientific medical society “Medical practice”, Avdeev S. N. ,   Federal State Autonomous Educational Institution of Higher Education “First Moscow State Medical University named after I. M. Sechenov” of the Ministry of Health of the Russian Federation, Tumenko E. E. ,   Federal Scientific State Budgetary Institution «N. A. Semashko National Research Institute of Public Health»,   Non-government organization «Scientific medical society “Medical practice”
Published: February 2025

Treatment of patients with bronchial asthma and chronic obstructive pulmonary disease reduces the severity of symptoms and the frequency of exacerbations and significantly improves the quality of life of patients, which makes the provision of medications to these patients highly important.
The purpose of the study is to study the accessibility of patients with broncho-obstructive diseases to drug treatment in the Russian Federation depending on the dynamics of the cost of drugs in 2019–2023.
Materials and methods. The number of purchased dox/milligrams of drugs for the treatment of patients with broncho-obstructive diseases, as well as the amount of funds spent, were analyzed; The weighted average treatment for each pharmacological class of drugs in 2019 and 2023 was calculated.
Results. The amount of consolidated funds from all sources of financing spent on the purchase of all drugs in 2019 amounted to 19.9 billion rubles and increased by more than 60% over four years, reaching 32.1 billion rubles in 2023. The bulk of the funds in both 2019 and 2023 were ICS/DDBA, amounting to 40% and 32%, respectively. The number of annual courses of treatment for all drugs during this observation period increased by 6%, the largest increase was found in the group of monoclonal antibodies (+195). In the same group of drugs, the maximum increase in the weighted average cost of an annual course of treatment was noted (+103%). In general, with drug costs increasing by more than 60% in 2023, the number of head courses of treatment in 2023 increased by 6% compared to 2019.
Conclusions. The availability of drug treatment for patients with BOD in 2023 has not changed compared to 2019. The cost of drugs did not affect the access to drug treatment for patients with BOD, but increased the costs of both the state and patients’ funds for the purchase of drugs.
Pengaruh Kombinasi Pakan Komersial Dengan Cacing Sutra (Tubifex sp) Terhadap Pertumbuhan Berat Mutlak Ikan Gurame (Osphronemus gouramy L)
Authors: Wibowo Pandu , Hayati Nurul , Wirawan Indra , Agustini Maria
Published: February 2025

Penelitian ini bertujuan untuk mengetahui pengaruh kombinasi pakan komersial dengan cacing sutra (Tubifex sp) terhadap pertumbuhan bobot absolut ikan gurami (Osphronemus gouramy L). Metode dalam penelitian ini menggunakan metode eksperimen dengan pengumpulan data yang dilakukan secara obstruktif secara langsung. Desain eksperimen yang digunakan dalam penelitian ini berupaRancangan Acak Lengkap (RAL) dengan 5 kombinasi pakan pellet dan ulat sutera yang berbeda, yaitu: Perlakuan (A) Pakan komersial (Pellet) 100%.; Perawatan (B) Pakan komersial (Pelet) 75% + 25% ulat sutera; Perawatan (C) Pakan komersial (Pelet) 50% + 50% ulat sutera; Pengobatan (D) Pakan komersial (Pelet) 25% + 75% ulat sutera; Pengobatan (E) ulat sutera 100%. Hasil penelitian yang memberikan nilai terbaik bagi pertumbuhan berat ikan mas (Osphronemus gouramy L). dalam perlakuan (D) pakan komersial (Pelet) 25% + 75%) dari 2gram. Hasil penelitian pengamatan kualitas air menunjukkan bahwa keseluruhan masih pada kadar optimal untuk mendukung kelangsungan hidup ikan mas (Osphronemus gouramy) dengan suhu 27 – 29 ºC. pH 7,1 – 7,5. Oksigen terlarut 5,3 - 5,7 ppm. Kata kunci: berat mutlak, ikan gurami, kombinasi, pakan
Design and Development of Drug Formulation Classification Information System
Authors: Setiawan Retno Agus , Al-Hakim Rosyid Ridlo , Trivilia Indah , Juniarti Ulan
Published: February 2025

The increasing complexity of pharmaceutical management in pharmacies demands efficient systems to streamline drug classification and inventory control. As pharmacies handle a diverse range of formulations, including tablets, syrups, and injectables, the need for advanced systems that ensure accuracy, efficiency, and compliance is becoming increasingly evident. This study focuses on the design and development of a web-based Drug Formulation Classification Information System, specifically tailored to improve the management of drug formulations. The system was developed using a Rapid Application Development (RAD) approach with a focus on user-centered design, prioritizing the needs and experiences of end-users, particularly pharmacists and administrators. Core functionalities incorporated into the system include real-time inventory updates, advanced drug search and classification, and automated report generation to simplify daily operations. To evaluate system performance and user experience, usability testing was conducted with pharmacists from UHB Educational Pharmacy. Results indicated a high user satisfaction rate, with 85% of participants finding the system intuitive and easy to use. The system’s architecture features a clear and intuitive user interface that minimizes the learning curve, ensuring that both experienced and novice users can navigate the platform efficiently with minimal training. Feedback from testing aligned with the Technology Acceptance Model (TAM), emphasizing the importance of perceived ease of use and usefulness in driving system adoption and user satisfaction. This research contributes to the growing field of pharmacy informatics by offering a scalable, adaptable solution for pharmacy management, with potential for integration into larger healthcare systems. Future enhancements will focus on integrating predictive analytics and extending system capabilities to further support pharmaceutical operations and patient care.
Air Temperature Prediction System Using Long Short-Term Memory Algorithm
Authors: Faulina Ria , Nuramaliyah Nuramaliyah , Safitri Emeylia
Published: February 2025

Air temperature is a highly essential parameter in weather forecasting methods and a critical variable for predicting future weather patterns. An accurate temperature prediction system can assist individuals and organizations in preparing for activities heavily influenced by weather conditions. Therefore, developing a precise temperature prediction model requires a reliable and effective algorithm. In this study, the Long Short-Term Memory (LSTM) algorithm, a type of artificial neural network (Recurrent Neural Network - RNN), is implemented with time series data decomposition for variable input processing. LSTM is specifically designed to handle sequential data or time series data, such as weather data. Additionally, LSTM-GRU and LSTM-Conv1D models are utilized. The dataset used in this research comprises air temperature data provided by the Meteorology, Climatology, and Geophysics Agency (BMKG) in the DKI Jakarta region. Model evaluation is conducted using criteria for the smallest Mean Absolute Error (MAE) and Root Mean Square Error (RMSE). Experiments show that the prediction system based on LSTM-GRU achieves the lowest MAE and RMSE values compared to LSTM and LSTM-Conv1D, across 10, 20, and 30-step predictions. It can be concluded that the LSTM-GRU algorithm provides the most accurate predictions compared to the LSTM and LSTM-Conv1D models for sequential temperature data, given sufficient data and a properly configured model. This is also graphically demonstrated by prediction results closely aligning with the actual data.
Towards rural proofing (in Spain): (un)founded expectations?
Authors: Esparcia Pérez Javier
Published: February 2025

This paper takes as its starting point the high expectations that rural proofing has been arousing in recent years in the European Union. Therefore, the main objective is twofold. Firstly, to carry out an analysis of the state of the art and situation of the RP in general, and in Spain in particular; secondly, to examine the situation and perspectives that this mechanism may have in Spain, considering the institutional environment, the organisational culture, the division of competencies, the (not excessively high) tradition of intersectoral cooperation at the different levels of government, etc. Through various specific objectives, a decalogue of the key aspects of rural proofing is drawn up, as a mirror against which to contrast the processes of practical implementation, and various aspects of the Spanish case are analysed. The conclusions point to the fact that, from our point of view, the rural proofing is the confirmation of the failure of a central aspect of the traditional place-based approach, the integrated approach. On the other hand, we examine the different limitations of the implementation of rural proofing in Spain. These suggest that we should be cautious with the probably excessive, and perhaps unfounded, expectations that have been generated in Spanish rural areas about the real possibilities of rural proofing.
El sistema web en la administración financiera de tesorería en una institución educativa Lima-2022
Authors:   , Alarco Basaldua Roby
Published: February 2025

No cabe duda que en los últimos años, tanto los sistemas web como los aplicativos móviles, han modificado ciertamente las formas de gestionar las empresas, y el sector educación no ha sido ajeno a ese cambio, incluso durante y la post pandemia, las Instituciones se han visto obligadas a implementar soluciones tanto académicas como de gestión financiera a fin de mantener en marcha sus Instituciones, sobre todo en el manejo de los recursos monetarios que tuvieron serias dificultades para el cumplimiento de sus obligaciones, es en este contexto es que he visto por conveniente desarrollar un software financiero web a fin de determinar que tanto influye la implementación de dicho sistema web en la administración financiera de tesorería en una Institución Educativa de Lima. Para el cual se ha incorporado en el sistema lo planteado por el autor Robles (2012) quien afirma que, si se controlan mediante indicadores las tres dimensiones de la administración financiera de tesorería que son: la estructura, la determinación del flujo de efectivo y la administración del efectivo habrá una mejora en la administración de tesorería concretamente en el manejo de los recursos monetarios, sumado a otros estudios donde afirman que un sistema financiero web contribuye en el manejo de Tesorería. El método de estudio del presente trabajo es hipotético deductivo, El tipo de investigación es aplicada, su diseño es pre-experimental. la población comprende la información de ingresos y egresos de 18 meses de los años 2021 y 2022, de los cuales se ha tomado como muestra seis meses de información representativa de marzo a agosto 2022. Para lo cual se ha considerado como objetivo general “Determinar la influencia del Sistema web en la Administración financiera de Tesorería en una Institución educativa, Lima-2022”...