bluuebunny/crossref_metadata_2025 huggingface dataset:
MICROBIOMES OF HUMAN, LIVESTOCK ANIMAL GASTROINTESTINAL TRACT, FOOD PRODUCTS AND COMPOUND FEEDS: CONNECTIONS AND IMPACTS. PART 2
Authors: Iegorov B. , Iegorova А. , Yeryganov K.
Published: August 2024

Research on the human gut microbiome began long ago and currently uses the latest modern methods and creates new insights and understanding. The human gut microbiome contains billions of microbial cells per 1 g of intestinal contents. These microbes include members of all superkingdoms: prokaryotes (kingdoms Bacteria and Archaea), eukaryotes (Fungi), and viruses. The taxonomic composition includes hundreds of bacterial species, dozens of archaeal and fungal species, and dozens of viral families. They are constantly in close connection and interaction with each other and with host cells and tissues. Methanogenic archaea have been shown to potentially impact the development of certain diseases, and fungi and bacteria are beneficial symbionts that have a significant impact on host health. Viruses are mostly bacteriophages that modulate bacterial populations. The impact on human health occurs through complex molecular mechanisms: microbes secrete biologically active metabolites that modulate cellular and tissue biochemical activity and, hence, the functioning of the immune system and other organs, including the CNS. In turn, the human body responds using its nervous and immune systems and local intestinal tissues that produce certain substances that modify the activity of microorganisms. This results in formation of a gut-brain axis consisting of afferent (to the brain) and efferent (from the brain) pathways. A correlation between the composition of the microbiota and the development of some intestinal and non-intestinal diseases, including neurodegenerative and behavioral disorders, has been shown. The human gut microbiota varies throughout a person's life, and differs significantly by age (from infancy to the elderly) in terms of the taxonomic proportions. At the same time, food products contain hundreds of species of microbes, i. e. various bacteria and fungi (yeast and mycelial). This food microbiota can have an impact on the gut microbiota, especially in children (infants, preschool) and elderly. However, this issue has not been investigated and should be studied in the future.
PROBIOTIC MICROORGANISMS IN BREAD SOURDOUGHS
Authors: Holubchyk D. , Khablenko A. , Dugan O. , Danylenko S. , Korzhenivska A.
Published: August 2024

The review allows for characterization and evaluation of the typical microbiota and probiotic properties of individual species isolated from various bread sourdoughs. It has been observed that an interest in using sourdoughs for bread making and studying their microbiota has been steadily increasing in recent years. However, an analysis of contemporary publications has revealed insufficient information regarding microorganisms characteristic of sourdoughs based on spelt, buckwheat, corn, rice, teff, amaranth, quinoa, barley, oats, chia, sorghum, beans, and peas. The most studied sourdoughs are those based on wheat and rye flour. A list of the most prevalent lactic acid bacteria (LAB) and yeasts isolated from sourdoughs has been established. It comprises Companilactobacillus paralimentarius, Fructilactobacillus sanfranciscensis, Lactiplantibacillus plantarum, Latilactobacillus sakei, Leuconostoc citreum, Levilactobacillus brevis, Pediococcus pentosaceus, Weissella cibaria, Weissella confusa, as well as Kazachstania humilis, Kazachstania unispora, Pichia kudriavzevii, Pichia fermentans, Saccharomyces cerevisiae and Wickerhamomyces anomalus. All typical mentions of the probiotic properties of microorganisms isolated from bread sourdoughs have been described. When isolating probiotics from bread sourdoughs, special attention should be paid to such species of LAB as Lactiplantibacillus plantarum, Levilactobacillus brevis, Pediococcus pentosaceus, Enterococcus faecium, as well as the yeasts Saccharomyces cerevisiae and Kazachstania humilis, as they are quite commonly found in sourdoughs from various types of flour and have the most conspicuous probiotic properties. According to the review, it has been established that stress tolerance and antimicrobial activity are typical probiotic properties for microorganisms isolated from sourdoughs, although antioxidant properties require further research. Advances in technology and increased economic accessibility will lead to increased demand for new probiotic strains and microorganisms from bread sourdoughs and may help meet new levels of consumer needs.
The Value and Evaluation of Educational Environments: The Case of Lithuanian General Education Schools
Authors: Survutaitė Dalia
Published: August 2024

Educational environments include different physical places, contexts, and cultures in which pupils are raised and learn. This article offers a retrospective view of the importance and significance of educational environments. Gradually, educational leaders, together with their communities, are reflecting on the adequacy of existing educational environments and acknowledging the necessity to update, adjust and create new ones.
Mutual Support Phenomenon: Voices of Students With Written Language Disorders
Authors: Grigienė Ieva , Galkienė Alvyra
Published: August 2024

Adopting a phenomenological approach, this study analyses the “children’s voice” which reveals how children experience the defining experiences of a written language disorder and gives meaning to the phenomenon of mutual support. The results of the study present the components of the mutual support phenomenon, through which the interpretationof their understanding is revealed: being empathetic, seeking recognition in the community, modelling learning activities, interpreting learning support.
A review of scientific papers on business model innovation, multi-level business model hypothesis
Authors: Kolyada Andrey
Published: August 2024

The author presents a detailed analysis of current views on the issue of business model innovation in foreign and Russian scientific sources. The main ideas and theses in this area are reflected, and an attempt is made to find general trends. Current scientific works of authors from different countries have been studied — mainly over the past 10 years. Most of the publications analyzed in the article were made in Scopus, Web Of Science (English-language) and VAK
(Russian-language) journals. Both well-known popular sources with a high citation rate, as well as completely new publications, which, however, presented original ideas, were analyzed. An attempt was made not only to reflect the points of view of different authors, but also to show how scientific thought in the field of business model innovation is developing in different regions of the world. Based on the results of the study, the author put forward a hypothesis about the multi-level nature of the business model. It is proposed to consider at least 3 levels of the business model: the holding (parent) company level (level 1), the level of an individual organization/business unit (level 2), and the
product-market level (level 3). The directions for future research arising from this hypothesis are outlined: defining the levels in the business model, clarifying the content of this concept at each level, establishing clear boundaries between the business model and the organization's strategy. The study was carried out as part of the work on the development of the Russian scientific school of business modeling and strategic management, which is carried out at the scientific institute «Eurasian Management and Administration School» (EMAS Business School).
Genetic variations and population differentiation in four species of shrikes based on mitochondrial (Mt) DNA cytochrome oxidase B gene
Authors: Muhammad Shahbaz , Imtiaz Ayesha , Ruby Tahira , Khan Aleem Ahmed
Published: August 2024

ABSTRACT: Members of the genus Lanius, known as shrikes, are economically important song birds distributed widely in several Asian countries. DNA sequencing, based on a partial segment of the cytochrome oxidase b (Cyt b) gene, was used to determine genetic variations and population genetic structure in four populations of shrike samples from north, east, and west Pakistan. We observed nucleotide diversities in L. isabellinus(= 0.02), L. schach(= 0.005), L. vittatus(= 0.004) and L. lahtora(= 0.008) . FST values were significant (P < 0.05) in all species populations apart from L. isabellinus, which were non-significant. The negative values of Fu’s Fs and Tajima’s D showed significant population expansion in three species, L. schach, L. vittatusand L. Lahtora, whereas they were insignificant in populations of L. isabellinus. Fu’s Fs and Tajima’s D values explain that a strong genetic structure is present among members of L. isabellinus. On this basis, it is inferred that strong genetic structuring in L. isabellinuspopulations within this region was largely shaped by a common origin, with secondary influences from geographical factors and isolation.
Contra el excepcionalismo antropocéntrico: subjetividades posthumanas en Las voladoras de Mónica Ojeda
Authors: Navarrete G. Carolina , Saldías Rossel Gabriel , Leal Ulloa Fabián
Published: August 2024

Resumen La colección de cuentos Las voladoras, publicada en 2020 por la escritora ecuatoriana Mónica Ojeda, consta de ocho relatos que están moldeados por una imaginativa mezcla de lo extraño, la violencia y lo femenino. Dentro de este contexto narrativo, el objetivo es abordar la construcción de los cuerpos de las mujeres como estructuras heterogéneas en relación con la violencia que deben enfrentar, configurando así subjetividades posthumanas. Proponemos que en estas historias existen relaciones entre humanos y no humanos que podrían estar asociadas con lo que Donna Haraway denomina "parentesco queer". Estas relaciones revelan formas de articular las identidades de las mujeres con una dimensión explícitamente colectiva y posthumana, donde el concepto de "convertirse-con" de Haraway se vuelve primordial: "Ser uno siempre es convertirse-con muchos". La razón por la que estas historias adoptan esta postura es porque las relaciones estrictamente humanas, especialmente las de los hombres hacia las mujeres, son altamente hostiles, marcadas por un exceso de poder y, por lo tanto, violencia. Esto motiva la necesidad de que las mujeres generen conexiones complejas, intergeneracionales y vitales entre ellas y con otras entidades vivas, donde dicho excepcionalismo humano pueda ser anulado, cuestionado y/o transformado.
B-Cell Epigenetic Modulation of IgA Response by 5-Azacytidine and IgA Nephropathy
Authors: Yu Shanshan , Li Xiang , Wang Ting , Li Jingyi , Li Hongzhi , Xu Ying , Hu Yanling , Zhu Fubin , Wang Jinwei , Wang Tianhe , Zhu Bin , Zhou Xu-jie , Zhang Hong , Lv Jicheng , Barratt Jonathan , Zhao Binghai
Published: August 2024

Key Points

Dysregulated IgA production plays a key role in the pathogenesis of IgA nephropathy.

Increased 5-methylcytosine modification, an epigenetic regulatory mechanism, exaggerated IgA nephropathy phenotype in mice.

Conversely, inhibition of 5-methylcytosine modification ameliorated progression of IgA nephropathy–like kidney disease in mice.

Background

IgA nephropathy is an important global cause of kidney failure. Dysregulation of IgA production is believed to play a key role in IgA nephropathy pathogenesis; however, little is known about the epigenetic mechanisms, such as RNA 5-methylcytosine (5mC) modification, in regulating IgA synthesis.

Methods

To decipher the role of RNA 5mC in regulation of IgA class switch, the microRNA (miR)-23b−/− and Lactobacillus casei (Chinese Industrial Microbial Culture Collection Center) cell wall extract–induced Kawasaki disease mice were treated with 5-azacytidine. Trdmt1
−/− and double Trdmt1
−/−/miR-23b
−/− mice and Aid
−/− mice or Aid
−/−/miR-23b
−/− mice were also used.

Results

We showed that miR-23b downregulated expression of Transfer RNA Aspartic Acid Methyltransferase 1 and consequently reduced 5mC (m5C) RNA modification and IgA synthesis in B cells. Inhibition of m5C RNA modification normalized serum IgA levels and ameliorated progression of the IgA nephropathy–like kidney disease in miR-23b
−/− and Kawasaki disease mice, while mesangial IgA and C3 deposition failed to develop in Trdmt1
−/−
miR-23b
−/− mice. By contrast, increased m5C RNA modification resulted in an exaggerated IgA nephropathy phenotype. miR-23b regulation of serum IgA levels and the development of an IgA nephropathy–like kidney disease in miR-23b
−/− and Kawasaki disease mice is likely mediated through TRDMT1-driven 5mC RNA modification in B cells, resulting in impaired activation-induced cytidine deaminase activity and IgA class switch recombination.

Conclusions

This study revealed TRDMT1-induced RNA 5mC methylation regulated IgA class switch, and inhibition of RNA 5mC by 5-azacytidine ameliorated progression of IgA nephropathy.
A IMPORTÂNCIA DO CUIDADO COM OS CUIDADORES DE PESSOAS COM DEFICIÊNCIA: REVISÃO SISTEMÁTICA
Authors: Teixeira Vitória Guimarães , Oliveira Márcia Farsura de
Published: August 2024

O Instituto Brasileiro de Geografia e Estatística indica que 8,9% da população brasileira possui alguma deficiência, ressaltando a importância dos cuidadores. A relação de cuidado é influenciada por fatores diversos, e os cuidadores enfrentam desafios significativos que afetam seu bem-estar físico e mental, necessitando de suporte adequado. Assim, objetivou-se revisar na literatura científica as necessidades e desafios enfrentados pelos cuidadores de pessoas com deficiência, enfatizando a importância do cuidado e buscando, assim, meios de promover a qualidade de vida e articular ações de suporte. Fpara isso, realizou-se busca nas bases de dados PubMed e ResearchGate, utilizando os descritores "Cuidadores” AND “Pessoas com Deficiência"; "Cuidadores” AND "Promoção da Saúde"; "Cuidadores” AND "Saúde Mental" e "Cuidadores” AND "Qualidade de Vida". A busca foi limitada a artigos publicados em inglês ou português de 1990 até março de 2024. Foram incluídos estudos que investigavam os impactos físicos, emocionais e sociais dos cuidadores de pessoas com deficiência e excluídos estudos que não atendiam aos critérios de inclusão. Após a triagem inicial, 12 artigos foram selecionados para a revisão. A análise desses estudos revelou altos níveis de estresse, ansiedade e depressão entre os cuidadores, além de impactos físicos adversos, isolamento social e sobrecarga de responsabilidades. Os fatores de risco e proteção associados ao bem-estar dos cuidadores incluíram apoio social, recursos financeiros adequados e acesso a serviços de apoio. Necessidades não atendidas foram identificadas, incluindo suporte emocional, financeiro e educacional. Estratégias de enfrentamento como busca de apoio emocional e participação em grupos de apoio foram destacadas como importantes para promover a resiliência dos cuidadores. Conclui-se que os cuidadores de pessoas com deficiência enfrentam desafios significativos que afetam seu bem-estar, e é necessário desenvolver políticas e programas de apoio para promover uma sociedade inclusiva e solidária.
Analysis of sodium monofluoracetate (compound 1080) in animal kidney tissue by LC-MS/MS v1
Authors: Langston Jim
Published: August 2024

This diagnostic method provides for the identification and quantitative analysis of sodium monofluoroacetate (Compound 1080) from kidney tissue using LC-MS/MS Sodium monofluoroacetate (Compound 1080) is an EPA Category I toxin. In the US, its use is restricted to licensed applicators who may use it in bait collars to protect small ruminants. Animal intoxication and deathare reported, giving a need for a rapid, sensitive diagnostic method for detection and quantitation of Compound 1080 in animal tissues, including kidney. This SOP describes an LC-MS/MS method for the identification and quantitative analysis of Compound 1080 in kidney tissue at low ppb levels (e.g. ~5ppb). The method is rapid, sensitive, and selective. Validation data (in-house and by an independent laboratory via collaborative study such as Blinded Method Test) are available upon request.
Establishment and Maintenance of Organotypic Cerebellar Slice Cultures (OCerSC) from Aged Mice v1
Authors: S. Smith Kaitlan , C Schisler Jonathan
Published: August 2024

This protocol outlines a method for culturing organotypic slices from aged mouse cerebellar tissue, maintaining the cerebellum’s complex three-dimensional structure and cellular composition ex vivo. This technique simulates various physiological and pathophysiological conditions to study neurodevelopmental and neurodegenerative disorders and synaptic plasticity mechanisms. Expected outcomes include detailed neuronal morphology and functional connectivity analyses at the cellular and circuit levels using advanced imaging, electrophysiological techniques, and biochemical analyses such as protein expression, gene expression, metabolic activity, oxidative stress markers, neurotransmitter levels, calcium imaging, and enzyme activity assays.
Optimization of the Distribution of Resource by Time Periods in Management in Digitalized Organizational Systems
Authors:   Voronezh State Technical University, Korchagin S. G. , Ryndin N. A. ,   Voronezh State Technical University
Published: August 2024

The article considers, on a general theoretical basis, two tasks of Optimizing the allocation of resources over time Periods in managing the development of a digitalized organizational system and in managing the mandatory activities of personnel to achieve the set goals of the functioning of the organizational system and to be distributed between stages and iterations. The application of an optimization approach for a new class of organizational systems — Agile-oriented systems, and for the development of a digital decision management environment in organizational systems is shown.
Audiências telepresenciais
Authors: Rodrigues Ivan Tauil , Teles Carlos André Coutinho
Published: August 2024

Este ensaio tem o propósito de verificar se as audiências realizadas por meios telemáticos violam ou não o princípio da imediatidade. A hipótese que se apresenta é no sentido de que, quando os magistrados de segunda instância se depararem com audiências de instrução e julgamento que tiverem sido gravadas pelo sistema audiovisual, se estes devem manter o entendimento sobre a aplicação do princípio da imediatidade. O trabalho tem o objetivo de propor uma mudança de postura (uma releitura) hermenêutica, direcionada aos tribunais de segunda instância quanto à interpretação e aplicação do princípio da imediatidade. A metodologia empregada foi o estudo bibliográfico da doutrina nacional e internacional, sobretudo o levantamento de pesquisa jurisprudencial realizada no sítio eletrônico do Tribunal Regional do Trabalho da 1ª região sobre o tema, com o emprego de método indutivo e dedutivo. Os resultados são propositivos, tendo a intenção de fomentar o debate sobre o tema e, de certa forma, empregar maior efetividade à prestação jurisdicional.
Órgãos essenciais à justiça e a democracia militante no contexto digital
Authors: Martins Plinio Lacerda , Martins Guilherme Magalhães , Tostes Eduardo Chow De Martino
Published: August 2024

Este trabalho busca explorar a função dos órgãos essenciais à justiça e o debate acerca da teoria da democracia militante no Brasil, no contexto digital. Compreender a teoria da democracia militante, analisar seu impacto no sistema brasileiro, observar as instituições públicas essenciais à justiça, ressaltada a relevância da presente discussão a partir das redes sociais são propostas elaboradas no presente texto. Traçaremos, ao final, considerações pela promessa de defesa efetiva da Democracia brasileira como uma necessidade no mundo físico e digital.
Análisis socio-jurídico del derecho de propiedad y sus mutaciones Actuale
Authors: Clerc Carlos Mario
Published: August 2024

El presente trabajo presenta como objetivo central analizar la cuestión de la propiedad indígena en latinoamérica, tomando como eje el derecho argentino, haciendo hincapié en las implicancias socio-económicas de ella
Ativismo judicial
Authors: Silveira Túlio Belchior Mano da , Aufiero Mário Jumbo Miranda , Thamay Rennan Faria Kruger
Published: August 2024

O termo ‘ativismo judicial’ pode ser definido, sucintamente, como a atuação de cortes jurisdicionais para corrigir eventuais omissões legislativas em face da análise e da leitura dos princípios constitucionais. Este tema vem sendo muito discutido na história recente do Brasil, haja vista o cenário de polarização de ideias que o país vivencia, discussões que são por vezes alimentadas por críticos ao Supremo Tribunal Federal e sua atuação tida por estes como parcial, ferindo assim a divisão dos poderes Judiciário, Executivo e Legislativo, que conforme reza o artigo segundo da Constituição, são harmônicos e independentes em si, não podendo haver a prevalência de um em detrimento de outro. Verificou-se que o ativismo judicial se mostrar um risco à sociedade no que diz respeito a decisões judiciais pautadas nos ideais pessoais defendidos pelo magistrado, porém, tal ativismo passa pela ausência de atuação dos outros dois poderes da república, Executivo e Legislativo, em exercer suas funções de forma republicana, ou seja, não agindo de acordo somente com as necessidades de ocasião, mas no sentido de oferecer pacificação social através de leis e de suas aplicações concretas. O que se pode objetivar, é a construção de um modelo de convivência de fato harmônica entre estes poderes através dos princípios constitucionais e do debate democrático.
O efeito blacklash dos tribunais de contas subnacionais ao ativismo judicial na delimitação da competência sobre o julgamento dos atos de gestão dos chefes do poder Executivo
Authors: Pereira Luiz Carlos Azevedo Costa , Aufiero Mário Jumbo Miranda , Novelli José Carlos , Thamay Rennan Faria Kruger
Published: August 2024

O artigo tem por objetivo apresentar o ativismo judicial decorrente da ampliação da atuação revisora do Judiciário sobre as esferas constitucionais de competências dos demais Poderes e órgãos de extração constitucional. Como foco na jurisdição constitucional, a discussão se volta para a delimitação do juiz natural no controle de atos de gestão, especificamente nas contas anuais de Chefes do Poder Executivo. Em vista disso, o artigo parte da seguinte problemática:  A intervenção judicial do STF na extensão da competência judicante dos Tribunais de Contas sobre as contas de gestão dos Chefes do Poder Executivo configura um caso de judicialização do direito ao juiz natural ou uma prática de ativismo judicial? E a postura reativa dos Tribunais de Contas de resistência à plena eficácia dos Precedentes firmados nos temas 157 e 835 do STF pode ser enquadrada como um contra-ataque institucional ou se trata de um legítimo exercício da técnica de distinguish? Para tanto, a pesquisa adota a metodologia que envolve revisão bibliográfica, análise de precedentes e levantamento de acórdãos. A estrutura do artigo contempla seis partes, incluindo a introdução. A pesquisa aborda o princípio do juiz natural nos processos de controle externo, a competência dos Tribunais de Contas, a possibilidade de ativismo judicial, a resposta dos Tribunais de Contas e da Atricon, a rejudicialização da matéria e as implicações para a separação de poderes. O estudo leva a conclusão de que a falta de pacificação da questão gera reações dos Tribunais de Contas, notadamente da Atricon, buscando preservar suas competências. A situação expõe um fenômeno de backlash, caracterizado por reações sociais e políticas a soluções judiciais polêmicas. A investigação é relevante para futuros estudos sobre a validade jurídica do julgamento de contas anuais de gestão de Prefeitos Municipais e os limites interpretativos do STF sobre as competências dos Tribunais de Contas.
O código de normas do serviço extrajudicial do estado do Tocantins e o estímulo à solução consensual de conflitos através das serventias extrajudiciais
Authors: Salgado Buenã Porto
Published: August 2024

O presente estudo sobre acesso à justiça, analisa às disposições do Provimento nº 3 da CGJUS do TJTO que institui a Consolidação das Normas e Procedimento do Serviço Extrajudicial da Corregedoria-Geral da Justiça do Estado do Tocantins e as medidas de incentivo à solução consensual dos conflitos através das Serventias Extrajudiciais.
Doğrusal Vektör Kuantizasyon Modeli Kullanılarak Yapay Sinir Ağlarıyla Beton Basınç Dayanımı Kontrol Şemalarında Örüntü Tanıma
Authors: YILMAZ Şebnem KOLTAN , YÜCEL M. Mustafa
Published: August 2024

Bu çalışmada amaç, işletmenin kalite amaçlarının yerine getirilmesi olarak tanımlanan süreçte ortaya çıkan ya da gelecekte meydana gelebilecek hataları tespit etmek ve bunları iyileştirmek için Yapay Zeka (YZ) tekniklerinden biri olan Yapay Sinir Ağları’nın (YSA) uygulanabilirliğini göstermektir. Böylece kalite düzeyini yükseltmek, işletme maliyetlerini azaltmak, zaman tasarrufu, çalışanları motive etmek, müşteri şikayetlerini azaltmak gibi kalite kontrolünün gerekleri olan temel amaçlara katkı sağlanabilecektir. Bu kapsamda, hazır beton üreten bir işletmenin en önemli kalite göstergelerinden biri olan basınç dayanım ortalamaları kullanılmıştır. YSA modeli olan Doğrusal Vektör Kuantizasyon (DVK) modeli kullanılarak kontrol şemalarına ilişkin kalite karakteristiği gözlem değerleri ve kontrol şemalarına ilişkin parametrelerle iki model kurulmuş, modeller karşılaştırıldığında kalite karakteristiği gözlem değerleriyle oluşturulan modelin kontrol şemalarına ilişkin parametrelerle oluşturulan modele göre daha başarılı sonuçlar verdiği ortaya konmuştur.
Innovative methods for solving the problem of female infertility associated with endocrine disorders
Authors: Anvarova Sh. A. , Shukurov F. I. , Tulametova Sh. A.
Published: August 2024

Aim: to analyze the publications assessing innovative methods of diagnostics and treatment used to solve the problem of female infertility associated with endocrine disorders.

Materials and Methods. There was conducted a search for publications in electronic databases PubMed, Google Scholar, and eLibrary, which were selected in accordance with the PRISMA guidelines. All relevant articles published up to January 2024 were included in the review. As a result, 374 publications retrieved from PubMed, 147 – from eLibrary, and 33 – from Google Scholar were extracted. Duplicates and non-full-text versions of articles were excluded. After the selection procedure, 72 publications were included in the review.

Results. During the data analysis, we identified key aspects providing deeper understanding of endocrine disorders affecting female infertility. In particular, new correlations were demonstrated between the level of select hormones and treatment success, as well as pathogenetic mechanisms were also identified influencing the conception and pregnancy process. These results will allow to develop more accurate diagnostic criteria and effective treatment methods able to increase women's chances of successful conception and pregnancy.

Conclusion. The data analysis identified the hallmark aspects for diagnostics and treatment of female endocrine infertility, with new diagnostic criteria and effective treatment methods identified able to markedly improve outcomes. The crucial potential of the innovative approaches and methods considered contributes to improving reproductive health and increasing the chances of successful conception. We strongly encourage the introduction of such advanced technologies into clinical practice to optimize reproductive success.
Coenzyme Q10 and embryonic development: a potential role in reproductive medicine
Authors: Khamadyanova A. U. , Mannanov R. M. , Smakova D. M. , Musaeva F. I. , Bedelov D. G. , Ibragimov A. E. , Rusinova A. A. , Salikhova M. M. , Shtukaturova S. V. , Doroshenko T. V. , Fattakhova M. V. , Rakhimova M. K. , Marinova L. R.
Published: August 2024

Maternal mitochondria provide energy to the embryo through oxidative phosphorylation before blastocyst implantation, where intracellular energy is mainly supplied by glycolysis. Thus, it is obvious that mitochondria play a crucial role in providing energy for embryogenesis. Coenzyme Q10 (CoQ10) is a powerful endogenous membrane-localized antioxidant that protects circulating lipoproteins from lipid peroxidation. The results of several recent clinical studies have shown that exogenous CoQ10 supplements exert antioxidant effects and may be a potential therapy to reduce oxidative stress. CoQ10 deficiency increases the risk of impaired embryonic development; however, this relationship remains unclear. Given that CoQ10 level is influenced by enzymes involved in its synthesis, it is difficult to say whether the disorders are caused by CoQ10 deficiency or directly result from defects in the target gene. It has been shown that in the absence of CoQ10, ATP synthesis decreases in parallel with increased oxidative stress in mitochondria, two biological events which affect embryonic development. The review highlights the importance of CoQ10 as an antioxidant for improving egg quality, and also emphasizes its key role in embryonic development. It is necessary to conduct further studies aimed at studying metabolic changes during embryogenesis, as well as the mechanism of CoQ10 effects.
Network Stability Based Multicriteria Weighted MPRs Selection Algorithm for Mobile Ad Hoc Networks
Authors: Abdellaoui Ayoub , Elmhamdi Jamal
Published: August 2024

Manets are self-governing networks using several mobile nodes, which communicate together through wireless media, without the necessity of prior infrastructure. Therefore, due to highly dynamic and unconfident environments, Manets are weak to guarantee link lifetime, security, reliability and stability. Since, mobility, energy and security are the main factors for improved performance in the network. Paths and relay devices with enhanced stability and security are considered as critical subjects. The study suggests an improved process based on a Multicriteria purpose consistent with numerous systems of measurement. These systems of measurement are energy level, trust measure and mobility of mobile nodes. The concept is to select improved Multipoint relays (MPRs) able to transmit data efficiently, and increase lifetime and reachability. The proposed improvement supports the routing and the selection of paths. The selection of the greatest effective relay nodes can enhance the classification performance. The scheme is based on the OLSR protocol and performance results are defined using the network simulator (NS3) with different movement models. The results showed significant improvements in MCW_OLSR. The proposed version enhances network proficiency for different mobile environments.
Calculating resonant frequencies of axisymmetric oscillations of isotropic cylindrical disks
Authors: Skalozub S. L.
Published: August 2024

Resonant axisymmetric oscillations of cylindrical disks made of isotropic materials are analytically considered in accordance with the Kog theory. Relationships of dimensionless resonant frequencies to the geometrical dimensions of the disks and the dynamic characteristics of the material (Poisson’s ratio and shear wave velocity) are presented in a form convenient for calculations. Digital values of resonant frequencies are calculated and summarized in tables at different Poisson’s ratios ranging between 0.20 and 0.45, with a step of 0.05, for a number of discrete thickness-to-diameter ratios ranging from 0 to 0.853145 and from 0 to 0.30 when oscillations of the first and second modes are exited, respectively. The estimation of method errors in resonant frequency calculations based on the comparison with the known results obtained by the RayleighRitz method has proved their high repeatability. Instrumental errors in determining the dynamic characteristics of the material are calculated in relation to experimental results obtained in a number of well-known studies.
Effect of insulin on the phosphoproteome of skeletal muscles in normal conditions and with insulin resistance
Authors: Yakupova Elmira I. , Popov Daniil V.
Published: August 2024

The skeletal muscles are the main site of insulin-dependent glucose uptake, and the development of insulin resistance in skeletal muscles is the main factor in the progression of insulin resistance in the whole organism. This disorder is associated with defects in the canonical insulin cascade regulating glucose uptake; however, the specific molecular mechanisms are still debatable. Global mass spectrometry-based phosphoproteomic analysis appears to be an optimal approach to studying complex signaling networks.
The review summarizes data from phosphoproteomic studies investigating changes in intracellular signaling in skeletal muscles upon insulin stimulation under normal conditions and insulin resistance. In vitro and in vivo studies have shown that insulin stimulation/food intake causes large-scale changes in the phosphoproteome (hundreds of phosphosites). These changes affect not only the canonical insulin cascades but also other signaling pathways and proteins with different functions (enzymes of carbohydrate and fat metabolism, sarcomeric and mitochondrial proteins, transcription factors, chaperones, etc.) and cause transcriptomic changes. Insulin resistance impairs the phosphoproteomic response to insulin; however, these changes only slightly affect the canonical insulin cascade regulating glucose uptake. The causes of impairments in insulin-dependent glucose uptake are hypothesized to be related primarily by a combination of multiple defects in various signaling molecules that regulate glucose uptake directly or indirectly; however, they are not associated with the canonical insulin cascade.
TOKSİK LİDERLİĞİN AKADEMİK HAYATTAKİ KARANLIK SERÜVENİ
Authors: Çiçek Berat , Bilkay Sibel
Published: August 2024

Liderliğin birçok olumlu yönünün yanı sıra karanlık bir yüze sahip liderlerin organizasyonlara etkilerinin de araştırılması gerekmektedir. Bu bağlamda bu çalışmada toksik liderliğin psikolojik iyi oluş üzerindeki etkisi ve bu iki değişken arasındaki ilişkide çalışan sessizliği ile işyeri dedikodusunun aracı rolünün araştırılması amaçlanmıştır. Bu doğrultuda İstanbul’daki üniversitelerde çalışan 544 akademisyen ile nicel bir araştırma gerçekleştirilmiştir. Elde edilen veriler Yapısal Eşitlik Modeli (YEM) yaklaşımı benimsenerek analiz edilmiştir. Araştırma bulgularına göre toksik liderliğin psikolojik iyi oluşu olumsuz etkilediği tespit edilmiştir. Ayrıca çalışan sessizliği ile işyeri dedikodusunun, toksik liderlik ile psikolojik iyi oluş arasındaki ilişkisinde aracı role sahip olduğu sonucuna ulaşılmıştır.
ÇEVRE BİLİNCİ VE ÇEVRE VERGİSİ BİLİNCİ ÜZERİNE AMPİRİK BİR DEĞERLENDİRME
Authors: Tabakan Gülin , Yılmaz Büşra , Canlı Yunus Emre
Published: August 2024

Bu çalışmanın amacı, bireylerde çevre bilinci ve çevre vergisi bilinci arasındaki ilişkiyi araştırmaktır. Buna ek olarak, çevre bilinci ve çevre vergisi bilincinin demografik değişkenlere (cinsiyet, yaş, medeni durum, eğitim durumu, ikametgâh, gelir düzeyi, meslek) göre farklılıklarını belirlemek amaçlanmıştır. Bu amaçlar doğrultusunda Ankara, İstanbul ve İzmir illerinde ikamet eden bireylere anket uygulaması yapılmış, 952 geçerli anket değerlendirmeye alınmıştır. Gerçekleştirilen analizler sonucunda; yaş, eğitim durumu ve ikametgâh değişkenleri ile çevre bilinci; yaş, medeni durum ve meslek değişkenleri ile çevre vergisi bilinci arasında istatiksel olarak anlamlı farklılıklar tespit edilmiştir. Diğer demografik değişkenlerle çevre bilinci ve çevre vergisi bilinci arasında istatiksel olarak anlamlı bir farklılık bulunamamıştır. Çalışmada bireylerin çevre bilinci ve çevre vergisi bilinci arasında orta düzeyde pozitif yönde anlamlı bir ilişki saptanmıştır. Basit doğrusal regresyon analizi sonuçlarına göre, bireylerin çevre vergisi bilinç düzeyindeki değişimin %43'ünü çevre bilincindeki değişimin açıkladığı belirlenmiştir. Çevre bilincindeki 1 birimlik artışın ise çevre vergisi bilinci üzerinde 0,707 birimlik bir artışa sebep olduğu gözlemlenmiştir. Bu bulgulardan hareketle hem çevreye hem de çevre vergilerine yönelik bilinci artırma hususunda; eğitimlerin artırılması, hükümetler tarafından oluşturulan politikalar kapsamında çevre vergilerinin etkili kullanımını sağlayacak mekanizmaların geliştirilmesi, çevreye duyarlı ve yeni nesil teknolojilerin kullanımına yönelik teşviklerin çoğaltılması büyük önem taşımaktadır.
ORGANİK GIDAYA DAİR GÜVEN UNSURLARININ TÜKETİCİLERİN SATIN ALMA DAVRANIŞINA ETKİSİ
Authors: Yemez İbrahim , Delice Akca Tuğba
Published: August 2024

Organik ürün, içeriğinde kimyasal maddeler ve sağlığa zararlı unsurlar barındırmayan ve daha çok gıda ürünleri için kullanılan bir kavramdır. Organik ürün pazarı da her geçen gün büyümektedir. Bu bağlamda bu çalışmada organik ürüne dair güven unsurlarının tüketicilerin satın alma davranışı üzerindeki etkisi faydacı tüketim açısından ele alınmak istenmiştir. Bu amaçla 1-30 Haziran 2021 tarihlerinde 18 yaşından büyük, toplam 366 kişiden çevrimiçi anket tekniği ile veriler toplanmıştır. Elde edilen verilere ilk olarak Doğrulayıcı Faktör Analizi uygulanmıştır. Bu analizle kullanılan ölçeğin uyum ve ayrışma geçerliliği ile iç tutarlılığı ortaya konmuş ve ölçeğin geçerli ve güvenilir olduğu görülmüştür. Daha sonra araştırma modeli YEM altında Yol Analizine tabi tutulmuştur. Analiz sonucunda organik gıda etiketi, yüksek fiyat ve yerli üretim değişkenlerinin faydacı tüketimi olumlu anlamda etkilediği ve ayrıca faydacı tüketim davranışının da satın alma davranışını olumlu yönde etkilediği bulunmuştur. Ancak çevresel bilinç ve sağlık içeriği değişkenlerinin hem faydacı tüketim hem de satın alma davranışı üzerinde doğrudan ve dolaylı, anlamlı bir etkisinin olmadığı bulunmuştur.
KATILIM VE MEVDUAT BANKALARI FİNANSAL SAĞLAMLIKLARININ BANKOMETER YÖNTEMİ İLE KARŞILAŞTIRMALI ANALİZİ
Authors: Şahin Tuğçe , Mısırdalı Yangil Fulya
Published: August 2024

Bu çalışmanın amacı, Türkiye’de faaliyet gösteren katılım ve mevduat bankalarının finansal sağlamlıklarını literatürde henüz yeni kullanılmaya başlanan Bankometer S-Skor yöntemi yardımıyla incelemektir. Çalışmada ayrıca, katılım ve mevduat bankalarının finansal sağlamlık düzeyleri de karşılaştırılmıştır. Çalışmada, 2016–2022 yılları arasında Türkiye'de faaliyet gösteren beş adet katılım bankası ve üç adet kamu sermayeli, sekiz adet özel sermayeli, on beş adet yabancı sermayeli mevduat bankası olmak üzere toplamda otuz bir adet bankanın finansal sağlamlıkları analiz edilmiştir. Çalışmaya ilişkin bulgular incelendiğinde, tüm bankaların S-Skorları 70’in üzerinde olduğu gözlemlenmiştir. Bu durum tüm bankaların finansal anlamda güçlü, borç ödeme güçlerinin yüksek ve finansal krizlere karşı dayanıklı olduğunu göstermektedir. Ayrıca araştırma sonuçlarına göre mevduat bankalarının lider konumda yer aldığı sonucuna ulaşılmıştır. Mevduat bankaları içerisinde de yabancı sermayeli bankaların lider konumda olduğu tespit edilmiştir.
İŞLETMELERDE YAPAY ZEKÂ UYGULAMALARININ MUHASEBE SÜRECINE VE SÜRDÜRÜLEBILIRLIK AMAÇLARINA KATKILARININ İNCELENMESI: SÜRDÜRÜLEBILIRLIK ENDEKSINDEKI İŞLETMELERDE BIR ARAŞTIRMA
Authors: Akpınar Aynur , Derya Baskan Tuba
Published: August 2024

Öz
Günümüzde yapay zekâ (artificial intelligence-AI) uygulamalarının kullanımı giderek yaygınlaşmakta ve gündelik hayatta gerçekleşen pek çok süreçte önemli rol almakta oldukları görülmektedir. Devlet yönetiminde, işletmelerde gerçekleştirilen faaliyetlerde, eğitimde, sağlıkta ve bunlar gibi pek çok alanda yararlanılan yapay zekâ uygulamaları, karar verme ve politika geliştirme süreçlerini önemli ölçüde desteklemektedirler. Bu kapsamda yapay zekâ uygulamalarından sürdürülebilir kalkınma hedeflerinin gerçekleştirilmesinde de faydalanılmakta olduğu görülmektedir. Yapay zekânın muhasebe işlemlerinde kullanılmasının yaygınlaşmasıyla birlikte muhasebe meslek mensuplarının da daha analitik düşünebilen ve yorumlayıcı niteliklere sahip olan ve yapay zekâ teknolojisine sahip işlemleri kolaylıkla gerçekleştirebilen yeteneklerinin olmasının beklendiği görülmektedir. Çalışmada, Türkiye’de yayınlanmakta olan 78 adet sürdürülebilirlik raporundaki sürdürülebilir kalkınma amaçlarının gerçekleştirilmesinde yapay zekâ kullanımları araştırılmıştır. Ayrıca bu raporlar sektör bazında gruplandırılarak bu kapsamda analiz edilmiştir.
Optimizing Dropout Prediction in University Using Oversampling Techniques for Imbalanced Datasets
Authors:   Faculty of Engineering and Vocational, Universitas Pendidikan Ganesha, Singaraja, Bali, Indonesia, Arthana I Ketut Resika
Published: August 2024

The phenomenon of student dropout is a significant concern within universities. Institutions must accurately predict the likelihood of student dropout to address this issue effectively. The prediction of student dropout aids universities in identifying early signs of student challenges. Moreover, it enables institutions to implement proactive measures to mitigate dropout rates. This paper presents a novel approach for selecting a classification algorithm to predict student dropout to aid universities in identifying early signs of student dropout. Moreover, it enables institutions to implement proactive measures to mitigate dropout rates. Each university possesses its academic dataset attributes, which can be leveraged for predicting potential dropout cases of student dropout. Our methodology begins with attribute selection, dataset preprocessing, and comparative evaluation of classification algorithms based on priority performance metrics. The research case study is conducted at Universitas Pendidikan Ganesha (Undiksha). The model selection was based on comparing classification algorithm performance, including Naïve Bayesian, Decision Tree (DT), and K-Nearest Neighbors (KNN). The dataset for this research was collected from the Information Academic System of Undiksha, encompassing students who graduated or dropped out between 2013 and 2023. It should be noted that the dataset exhibits class imbalance. Hence, this research utilized the Synthetic Minority Over Sampling Technique (SMOTE) algorithm to address the imbalance in lowsized datasets. The original and oversampled datasets were subjected to each classification algorithm. We chose Recall as the primary evaluation metric to prioritize ensuring that actual dropouts are not incorrectly predicted as graduates. This research demonstrates that the KNN classification algorithm, applied to the oversampled dataset, achieves the highest Recall value of 93.5%, Precision of 94.1%, F1-Score of 93.5%, and AUC value of 97.9%.
Comparative efficacy of targeted therapies and immunotherapy in advanced non-small cell lung cancer: a systematic review
Authors: Cali Byron Cristobal Llongo , Jaramillo Jorge Eduardo Paredes , Navas Jennifer Alicia Álvarez , Quemag Carlos Alaín Buesaquillo , Serrano Natalia Quintero , Zambrano Wagnner Ariol Intriago , Vasquez Elias David Suarez
Published: August 2024

Targeted therapies and immunotherapies revolutionized advanced NSCLC treatment and outcomes. Targeted therapies exploit specific genetic mutations (e.g., EGFR, ALK, BRAF) to inhibit cancer growth while offering significant benefits in progression-free and overall survival. Targeted therapy drugs for advanced NSCLC include osimertinib, gefitinib, erlotinib, alectinib, brigatinib, lorlatinib, ceritinib, dabrafenib, trametinib, and crizotinib.Resistance and side effects like ILD and hepatotoxicity and cardiovascular issues remain challenges. Immunotherapies with checkpoint inhibitors PD-1, PD-L1, CTLA-4 enhance the immune system's ability and body becomes able to combat cancer. Drugs like pembrolizumab, nivolumab, and atezolizumab have shown good efficacy but immune-related adverse effects remain a significant concern. Combination therapies such as e.g., nivolumab and ipilimumab can be a better option which can be concerned because these therapies also show promise in enhancing treatment outcomes.
A comparative study of clinical and radiological outcomes of open tibia fractures, managed with uncoated versus antibiotic coated intramedullary interlocking nail
Authors: Meena Bhagvan P. , Sewawat Hitesh , Bhrambhatt Purvesh , Meena Umesh , Dhaker Anurag
Published: August 2024

Background: Open tibia fractures are a significant clinical challenge, especially in densely populated regions like Jaipur, Rajasthan, where elevated trauma incidence and diverse healthcare access issues compound treatment intricacies. This study compares the clinical and radiological outcomes of open tibia fractures managed with conventional uncoated intramedullary nails versus antibiotic-coated intramedullary interlocking nails. The introduction of antibiotic-coated nails aims to reduce the incidence of infection, a major concern in open fractures due to the direct exposure of the fracture site to the external environment.
Methods: A prospective, observational study was conducted at the department of orthopedics, SMS Hospital, Jaipur, focusing on a cohort of 100 patients with open tibia fractures treated from January 2016 to December 2018. Patients were included based on specific criteria, including the type of fracture and the treatment received, either with uncoated or antibiotic-coated intramedullary nails. Data were collected retrospectively from hospital and operation charts, with radiographs and clinical information reviewed independently by two authors.
Results: The comparison revealed a lower infection rate and a higher rate of bone union at 12 months in the group treated with antibiotic-coated nails versus the uncoated group. Specifically, the antibiotic-coated group showed a 10% lower infection rate and a 10% higher bone union rate.
Conclusions: The use of antibiotic-coated intramedullary nails for the treatment of open tibia fractures demonstrates a promising reduction in infection rates and improved bone healing, offering a significant advantage over traditional uncoated nails in managing these complex injuries.
Em busca de igualdade e justiça social para o acesso à informação:
Authors: Ngoepe Mpho , Mojapelo Makutla
Published: August 2024

Assim como em diversos países pelo mundo, o acesso à informação na África do Sul é um direito humano fundamental consagrado na Constituição e, subsequentemente, nas leis de liberdade de informação (FOI, em inglês). Apesar de a liberdade de informação ser um direito humano garantido pela Constituição, há evidências de que o exercício deste direito exige esforço considerável e, até certo ponto, tem um preço. O preço no contexto deste estudo refere-se às taxas de solicitação e de acesso estabelecidas na Lei de Promoção de Acesso à Informação da África do Sul, bem como ao valor gasto em recursos e ações judiciais movidas por cidadãos comuns que procuram exercer os seus direitos de acesso à informação pública. O objetivo deste estudo é explorar a liberdade de acesso à informação pública na África do Sul, com vista a estabelecer se os cidadãos comuns têm livre acesso à informação visando a justiça social. Para a condução deste estudo qualitativo, foram realizadas entrevistas com especialistas usando a técnica Delphi e análise documental para avaliar o preço do acesso à informação na África do Sul. Os resultados sugerem que o preço do acesso à informação é insustentável, principalmente para grupos marginalizados cujos direitos são violados todos os dias. Como resultado, os cidadãos comuns não têm acesso à informação e, portanto, podem não ser capazes de participar da tomada de decisão dos órgãos públicos, conforme rege o estado democrático. É necessário que o governo da África do Sul adote medidas para regulamentar as taxas de liberdade de informação, a fim de garantir a igualdade de acesso à informação para todos e tornar a liberdade de informação ‘livre'.