bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical Evolution and Risk Factors in Patients Infected during the First Wave of COVID-19: A Two-Year Longitudinal Study
Authors: Rescalvo-Casas Carlos , Pérez-Tanoira Ramón , Villegas Rocío Fernández , Hernando-Gozalo Marcos , Seijas-Pereda Laura , Pérez-García Felipe , Moríñigo Helena Moza , Gómez-Herruz Peña , Arroyo Teresa , González Rosa , Expósito Cristina Verdú , Lledó García Lourdes , Cabrera Juan Romanyk , Cuadros-González Juan
Published: June 2023

A limited number of longitudinal studies have examined the symptoms associated with long-COVID-19. We conducted an assessment of symptom onset, severity and patient recovery, and determined the percentage of patients who experienced reinfection up to 2 years after the initial onset of the disease. Our cohort comprises 377 patients (≥18 years) with laboratory-confirmed COVID-19 in a secondary hospital (Madrid, Spain), throughout March 3–16, 2020. Disease outcomes and clinical data were followed-up until August 12, 2022. We reviewed the evolution of the 253 patients who had survived as of April 2020 (67.1%). Nine died between April 2020 and August 2022. A multivariate regression analysis performed to detect the risk factors associated with long-COVID-19 revealed that the increased likelihood was associated with chronic obstructive lung disease (OR 14.35, 95% CI 1.89–109.09; p = 0.010), dyspnea (5.02, 1.02–24.75; p = 0.048), higher LDH (3.23, 1.34–7.52; p = 0.006), and lower D-dimer levels (0.164, 0.04–0.678; p = 0.012). Reinfected patients (n = 45) (47.8 years; 39.7–67.2) were younger than non-reinfected patients (64.1 years; 48.6–74.4)) (p < 0.001). Patients who received a combination of vaccines exhibited fewer symptoms (44.4%) compared to those who received a single type of vaccine (77.8%) (p = 0.048). Long-COVID-19 was detected in 27.05% (66/244) of patients. The early detection of risk factors helps predict the clinical course of patients with COVID-19. Middle-aged adults could be susceptible to reinfection, highlighting the importance of prevention and control measures regardless of vaccination status.
Structure of Bovine CD46 Ectodomain
Authors: Aitkenhead Hazel , Stuart David I. , El Omari Kamel
Published: June 2023

CD46, or membrane cofactor protein, is a type-one transmembrane protein from the complement regulatory protein family. Alongside its role in complement activation, CD46 is involved in many other processes, from T-cell activation to reproduction. It is also referred to as a pathogen magnet, because it is used as a receptor by multiple bacteria and viruses. Bovine CD46 (bovCD46) in particular is involved in bovine viral diarrhoea virus entry, an economically important disease in cattle industries. This study presents the X-ray crystallographic structure of the extracellular region of bovCD46, revealing a four-short-consensus-repeat (SCR) structure similar to that in human CD46. SCR1-3 are arranged linearly, while SCR 4 has a reduced interface angle, resulting in a hockey stick-like appearance. The structure also reveals the bovine viral diarrhoea virus interaction site in SCR1, which is likely to confer pestivirus specificity for their target host, CD46. Insights gained from the structural information on pestivirus receptors, such as CD46, could offer valuable guidance for future control strategies.
Unpacking the Complexity of COVID-19 Fatalities: Adverse Events as Contributing Factors—A Single-Center, Retrospective Analysis of the First Two Years of the Pandemic
Authors: Zińczuk Aleksander , Rorat Marta , Simon Krzysztof , Jurek Tomasz
Published: June 2023

In a retrospective analysis of 477 fatal COVID-19 cases hospitalised at a single medical centre during the period from 6 March 2020 to 30 June 2022, several factors defining those patients at admission were assessed, as well as the course of the hospitalisation and factors contributing to death. There was a predominance of men (59.3% (283)) burdened by comorbidities, with increased inflammation at admission. Patients aged ≥ 81 years were significantly more likely to be admitted to and die in infectious diseases units (IDU) due to respiratory failure, their hospital stays were shorter, and they were most likely not to receive specialist treatment. The most common COVID-19 complications included acute kidney injury in 31.2% (149) patients and thromboembolic complications in 23.5% (112). The course of hospitalisation was complicated by healthcare-associated infections (HAI) in 33.3% (159) of cases, more often in those treated with baricitinib (p < 0.001). The initial use of an antibiotic, although common (94.8% (452)), was unwarranted in almost half of the cases (47.6% (215)). Complications of hospitalisation (46.1% (220)) and adverse events involving staff (49.7% (237)) were found in almost half of the patients. In 88.7% (423) of the cases, death was due to respiratory failure in the course of SARS-CoV-2 infection. Adverse events during hospitalisation should be considered as an additional factor that, in addition to the infection itself, may have influenced the death of patients.
Emerging Hypervirulent Marek’s Disease Virus Variants Significantly Overcome Protection Conferred by Commercial Vaccines
Authors: Liu Jin-Ling , Teng Man , Zheng Lu-Ping , Zhu Feng-Xia , Ma Shu-Xue , Li Lin-Yan , Zhang Zhi-Hui , Chai Shu-Jun , Yao Yongxiu , Luo Jun
Published: June 2023

As one of the most important avian immunosuppressive and neoplastic diseases, Marek’s disease (MD), caused by oncogenic Marek’s disease virus (MDV), has caused huge economic losses worldwide over the past five decades. In recent years, MD outbreaks have occurred frequently in MD-vaccinated chicken flocks, but the key pathogenic determinants and influencing factors remain unclear. Herein, we analyzed the pathogenicity of seven newly isolated MDV strains from tumor-bearing chickens in China and found that all of them were pathogenic to chicken hosts, among which four MDV isolates, SDCW01, HNXZ05, HNSQ05 and HNSQ01, were considered to be hypervirulent MDV (HV-MDV) strains. At 73 days of the virus infection experiment, the cumulative incidences of MD were 100%, 93.3%, 90% and 100%, with mortalities of 83.3%, 73.3%, 60% and 86.7%, respectively, for the four viruses. The gross occurrences of tumors were 50%, 33.3%, 30% and 63.3%, respectively, accompanied by significant hepatosplenomegaly and serious atrophy of the immune organs. Furthermore, the immune protection effects of four commercial MD vaccines against SDCW01, CVI988, HVT, CVI988+HVT, and 814 were explored. Unexpectedly, during the 67 days of post-virus challenge, the protection indices (PIs) of these four MD vaccines were only 46.2%, 38.5%, 50%, and 28%, respectively, and the birds that received the monovalent CVI988 or HVT still developed tumors with cumulative incidences of 7.7% and 11.5%, respectively. To our knowledge, this is the first demonstration of the simultaneous comparison of the immune protection efficacy of multiple commercial MD vaccines with different vaccine strains. Our study revealed that the HV-MDV variants circulating in China could significantly break through the immune protection of the classical MD vaccines currently widely used. For future work, there is an urgent need to develop novel, more effective MD vaccines for tackling the new challenge of emerging HV-MDV strains or variants for the sustainable control of MD.
Modulatory Effect of Human Immunodeficiency Virus on Circulating p53, miR-21, and miR-125b: Any Diagnostic Implication?
Authors: Okoye Jude Ogechukwu , Ngokere Anthony Ajuluchukwu , Onyenekwe Chinedum Charles , Omotuyi Olaposi Idowu , Ogenyi Samuel Ifedioranma , Obi Chioma Maureen , Fasogbon Samuel Ayobami
Published: June 2023

Identifying immunocompromised women who are at risk of developing cervical cancer remains a challenge for clinicians. In an effort to identify the role of HIV in cervical carcinogenesis, this study evaluated the levels of normally downregulated oncomirs (miR-21, miR-146a, miR-155, miR-182, and miR-200c) and normally upregulated tumor suppressors (miR-let-7b, miR-125b, miR-143, miR-145, and p53 expression) associated with cervical cancer in the serum of women living with HIV (HIV+) and without HIV (HIV. Method: This case-control study included 173 women; confirmed HIV+ (n = 103) and HIV− (n = 70). Serum levels of miRNAs and p53 were determined using reverse transcriptase PCR. t-test and Pearson’s correlation analyses were carried out on the generated data. Result: A higher level of miR-21 was observed among HIV+ women compared with their HIV− counterpart (p = 0.028), whereas lower levels of miR-125, and p53 gene were observed among HIV+ women compared with HIV− women at p = 0.050 and 0.049, respectively. Significant direct relationships were observed between miR-21 and other oncomirs (p < 0.05) among HIV+ women. Conclusion: This study revealed that HIV contributes to cervical carcinogenesis by modulating circulating levels of miR-21, p53, and miR-125b. It suggests that these biomarkers could be used to identify at high risk for developing cervical cancer.
Effect of Aging on the Immune Response to Core Vaccines in Senior and Geriatric Dogs
Authors: Dall’Ara Paola , Lauzi Stefania , Turin Lauretta , Castaldelli Giulia , Servida Francesco , Filipe Joel
Published: June 2023

Elderly dogs are steadily increasing worldwide as well as veterinarians’ and owners’ interest in their health and wellness. Aging is not a disease, but a combination of changes negatively affecting the organism in general and the immune system in particular, resulting in a decline in protection over time. The aim of this study was to measure the specific serum antibody titers against the main dangerous and widespread viral diseases preventable by core vaccinations in senior and geriatric dogs using the in-practice test VacciCheck. A cohort of three hundred fifty elderly dogs was analyzed for Protective Antibody Titers (PATs) against CPV-2, CDV and CAdV-1. The age ranged from 5 to 19 years, with two hundred fifty-eight seniors (73.7%) and ninety-two geriatrics (26.3%), and 97.4% of them were vaccinated at least once in their lives. More than half of the entire study population (52.9%) had PATs simultaneously for all three diseases, with 80.5% seniors and 19.5% geriatrics. Specific PATs were found in 88.6% of aging dogs for CPV-2, 82.3% for CadV-1 and 66.0% for CDV, demonstrating that unprotected aging dogs represent a minority. Unexpectedly, the larger elderly dogs resulted as more protected than smaller ones for CPV-2. Protection then decreases over time, with geriatric dogs less protected than senior ones. Veterinary practitioners should therefore always consider whether to maintain core vaccinations in aging dogs as in adults on a three-year basis or opt instead for closer boosters (every 1 or 2 years). PATs for core vaccines could then represent a good biomarker of protection and their titration could become a standard of care, especially in such a sensitive period of the dogs’ life.
Differences of Nitrogen Transformation Pathways and Their Functional Microorganisms in Water and Sediment of a Seasonally Frozen Lake, China
Authors: Tian Zhiqiang , Zhang Sheng , Lu Junping , Shi Xiaohong , Zhao Shengnan , Sun Biao , Wang Yanjun , Li Guohua , Cui Zhimou , Pan Xueru , Li Guoguang , Zhang Zixuan
Published: June 2023

Nitrogen is one of the most important elements involved in ecosystem biogeochemical cycling. However, little is known about the characteristics of nitrogen cycling during the ice-covered period in seasonally frozen lakes. In this study, shotgun metagenomic sequencing of subglacial water and sediment from Lake Ulansuhai was performed to identify and compare nitrogen metabolism pathways and microbes involved in these pathways. In total, ammonia assimilation was the most prominent nitrogen transformation pathway, and Bacteria and Proteobacteria (at the domain and phylum levels, respectively) were the most abundant portion of microorganisms involved in nitrogen metabolism. Gene sequences devoted to nitrogen fixation, nitrification, denitrification, dissimilatory nitrate reduction to ammonium, and ammonia assimilation were significantly higher in sediment than in surface and subsurface water. In addition, 15 biomarkers of nitrogen-converting microorganisms, such as Ciliophora and Synergistetes, showed significant variation between sampling levels. The findings of the present study improve our understanding of the nitrogen cycle in seasonally frozen lakes.
Heterogeneous Fenton-like Photocatalytic Process towards the Eradication of Tetracycline under UV Irradiation: Mechanism Elucidation and Environmental Risk Analysis
Authors: Amarzadeh Mohamadamin , Azqandi Moslem , Nateq Kasra , Ramavandi Bahman , Khan Nadeem , Nasseh Negin
Published: June 2023

The problem of the deep elimination of antibiotics in environmental bodies is exceptionally warranted. In this work, a ternary nanocomposite of FeNi3/SiO2/CuS (FSC) was fabricated and then integrated with UV light irradiation and hydrogen peroxide as the heterogeneous Fenton-like photocatalytic system for the decomposition of tetracycline (TC) from aqueous media. During this process, various influencing parameters such as pH, catalyst dosage, initial content of TC, hydrogen peroxide (H2O2) dose, and operating time were explored. At optimized circumstances, i.e., 5 of pH, 10 mg/L of TC concentration, 150 mg/L of H2O2 dosage, and 200 min of degradation time, the elimination proportion of TC was 96%. The results of capture agent tests clarified that hydroxyl radical (HO•) played the predominant role in the photocatalytic decontamination of TC. Moreover, with the elevated contact time and content of H2O2, the efficiency of TC decontamination increased significantly. Additionally, the findings of the stability and reusability experiments of the fabricated nanocomposite showed that the percentage of TC removal decreased by only about 5% after six cycles. Furthermore, the photocatalytic mechanism of the decontamination of TC over the FSC photocatalyst was elucidated. Eventually, the non-carcinogenic risk analysis in the surface water sample was carried out using multiple photocatalytic processes for the first time. These outcomes obtained in this study validate that coupling the photocatalytic system and the H2O2 oxidation agent facilitates the elimination of a great variety of pharmaceutical contaminants from aqueous media.
Application of Same-Day Enterococcus qPCR-Based Analyses for Quality Assessment of Shorelines (Water and Sand) at Recreational Beaches
Authors: Saleem Faizan , Edge Thomas A. , Schellhorn Herb E.
Published: June 2023

Rapid water-quality monitoring methods for beach water and sand can be helpful for public health authorities to develop comprehensive beach monitoring programs. In this study, we evaluated the performance of the Enterococcus qPCR (USEPA 1609.1) method for quality monitoring of beach water and sand-porewater at two Niagara region beaches in Ontario, Canada (Lakeside and Sunset Beaches). While the USEPA 1609.1 method has been validated for beach water, its potential for assessing associated beach sands (which may function as a microbial reservoir) has not been fully explored. All beach water samples (n = 168) passed the qPCR quality control (QC). However, only 20 out of 48 (41.7%) sand-porewater samples passed the qPCR QC, potentially due to interference by soluble inhibitors. The proportion of the sand-porewater samples passing QC improved slightly to 63 out of 120 (52.5%) with a prefiltration step to remove sand and other large particles. The faecal indicator density in the sand-porewater, tested in parallel, did not correlate with the beach water faecal indicator density. Comparing beach water data for the same-day Enterococcus qPCR threshold with the previous-day E. coli culturing-based threshold across all beach days tested, Enterococcus qPCR analyses identified 3 (7%) and 7 (16%) false positive/lost beach days for Lakeside and Sunset Beaches, respectively. Additionally, of the total beach days tested, Enterococcus qPCR analyses identified 2 (5%) and 1 (2%) false negative/health-risk days for Lakeside and Sunset Beaches, respectively. Sand-porewater testing analyses identified days when faecal indicators (in the sand) exceeded beach water quality thresholds. Compared with conventional E. coli culturing, use of the same-day qPCR method would result in fewer beach postings and could identify several additional health-risk days (when the beaches may not be posted). Future studies could include additional prefiltration steps or modifications in the Enterococcus qPCR protocol to improve the method’s applicability for sand quality monitoring.
Enhancing Biocontrol of Harmful Algae Blooms: Seasonal Variation in Allelopathic Capacity of Myriophyllum aquaticum
Authors: Kitamura Rafael Shinji Akiyama , da Silva Ana Roberta Soares , Pagioro Thomaz Aurelio , Martins Lúcia Regina Rocha
Published: June 2023

Myriophyllum aquaticum has shown potential allelopathic effects for the biocontrol of cyanobacteria and cyanotoxins. However, the composition of allelochemicals and their biological effects may be influenced by seasonal changes. In this study, we investigated the impact of aqueous extracts of M. aquaticum collected in different seasons on the growth of Microcystis aeruginosa and the concentration of microcystin-LR. Plant samples were extracted using ultrasound cycles in aqueous solutions, and extracts at varying concentrations (0.1, 10, and 100 mg/L) and a control treatment were inoculated with M. aeruginosa, and cell growth was analyzed using a Neubauer chamber. Photosynthetic pigment quantification was used to measure physiological effects and liquid chromatography was used to evaluate the microcystin-LR concentrations. The extracts of plants collected during autumn and winter exhibited higher inhibition of M. aeruginosa growth and a reduction in photosynthetic pigments compared to those collected during spring and summer. These results can be explained by the higher presence of phenolic compounds in the composition of extracts from autumn and winter. Microcystin-LR concentrations were decreased at 10 and 100 mg/L, with the highest efficiency observed in autumn, while spring showed lower efficiency. Our findings suggest that M. aquaticum extracts have inhibitory potential on M. aeruginosa, particularly during the autumn season, making them a promising nature-based solution for the biocontrol of harmful algal blooms.
Sustainability Assessment of Urban Waterscape Belt Ecological Reconstruction Based on LCA–Emergy–Carbon Emission Methodology
Authors: Dai Desheng , Yao Di , Gao Yuchen , Zhang Junxue
Published: June 2023

Rivers play a key role in regulating urban ecology, which can improve urban climate while slowing the heat island effect. As one of embodied energy in the field of ecology, emergy theory can be used to quantitatively evaluate the ecological characteristics of a system. This will help to further explore urban ecological sustainability in this article. In this study, four ecological riverbank reconstruction projects have been executed to restore the ecology along the banks of the Jinchuan River in Nanjing, China, which focus on the key river–lakeside and waterfront space in the main urban area. The LCA–emergy–carbon emission method was applied through a series of indicators, including emergy indexes and carbon emission indicators. It is important to distinguish prior research, and few have utilized this approach on urban waterways and waterscapes. The results illustrate that the reconstruction system has obvious improvement significance to the whole river ecology. This change can also be seen when using LCA–emergy analysis. In a 20-year cycle, the emergy of the material production stage and maintenance phase account for a major emergy share, followed by the construction stage, transportation process, and design process stage. The sustainability (ESI indicator) has been improved after carrying out the reconstruction projects. By choosing water and gravel as the primary material, the carbon emission can be reduced. The water treatment process accounts for the vast majority of carbon emissions. Secondly, gravel also plays an important role in carbon emission. Finally, an improved measure (clean energy reuse) was conducted to enhance the ecology of the reconstruction projects and obtained a significant ecological sustainability boost.
Influences of Underwater Shield Tunnelling on River Embankment Seepage Stability Considering Various Overburden Thickness
Authors: Shu Wenyu , Ma Jingjing , Geng Ningning , Xiang Yang , Ma Shiyu , Li Xian , Tong Fang , Fang Shisheng
Published: June 2023

Underwater shield tunneling will disturb the soil near the river, especially in water-rich soft ground. This may cause a groundwater infiltration hydraulic gradient to exceed the critical value, leading to calamities, such as unexpected flooding or submerged erosion. To ensure the security of construction and the stability of river embankment seepage, it is crucial to assess the safety of the underwater tunnel cover thickness. A shield tunnel project under a river in Hefei is used as an example. The numerical model established by the finite element method is used for calculating and analyzing the changes in the groundwater flow field and the stability state of embankment seepage induced by underwater shield tunneling under different overburden thickness conditions. The results show that the construction disturbance of the shield tunnel through the river is increased, the internal force environment of the embankment slope is destroyed, and the maximum seepage hydraulic gradient is increased. In the case study, the embankment keeps in a stable state of seepage when the cover thickness of the shield tunnel has 2.9 times its outer diameter. The findings of this study can serve as a scientific guide to assure seepage stability in an underwater shield tunneling project and to stop river embankment erosion.
Modeling Rainwater Harvesting and Storage Dynamics of Rural Impoundments in Dry Chaco Rangelands
Authors: Niborski Marcos Javier , Martin Osvaldo Antonio , Murray Francisco , Jobbágy Esteban Gabriel , Nosetto Marcelo Daniel , Paez Ricardo Andrés , Magliano Patricio Nicolás
Published: June 2023

Transporting water to supply livestock is one of the great challenges of the drylands. Ranchers usually make impoundments, filled by runoff, to access freshwater for cattle supply in flat rangelands. The aim of this study was to understand rainfall-runoff generation and water storage temporal dynamics of impoundments in the Dry Chaco rangelands (Argentina). Thus, we instrumented six impoundments over three consecutive years and analyzed water storage data by developing a probabilistic model. For all impoundments, the rainfall event size thresholds to generate runoff presented values between 15 and 33 mm. Once they reached this threshold, the water gain response slopes presented values between 19 and 99 m3 mm−1. Loss patterns of water storage were described by exponential or linear functions. The predicted water storage dynamics presented high accuracy with the observed time series for all impoundments (RMSD between 380 and 1320 m3). The model only needs daily rainfall and air temperature to be run, making it easy to be used by scientists, ranchers, or local decision makers. It may be used to explore the hydrological functioning of small and seasonal water bodies of different sites of the world exposed to drought episodes caused by high climate variability and/or climate change.
Rethinking Vasopressin: New Insights into Vasopressin Signaling and Its Implications
Authors: Watts Jason A. , Arroyo Juan Pablo
Published: June 2023

Vasopressin is a highly conserved peptide hormone that has been traditionally associated with water homeostasis. There is accumulating evidence in both humans and animal models that vasopressin is implicated in the regulation of metabolism. This review focuses on the effects that vasopressin exerts on the regulation of glucose and fatty acids with a particular emphasis on the potential repercussions of metabolic dysregulation in kidney disease.
The Effect of Elective Ligation of the Arteriovenous Fistula on Cardiac and Renal Functions in Kidney Transplant Recipients
Authors: Masson Grégoire , Viva Tommaso , Huart Justine , Weekers Laurent , Bonvoisin Catherine , Bouquegneau Antoine , Maweja Sylvie , Hamoir Etienne , Seidel Laurence , Pottel Hans , Lancellotti Patrizio , Jouret François
Published: June 2023

Key Points

Surgical AVF ligation in KTRs is associated with a significant increase in diastolic BP while systolic BP remains stable.

AVF closure in KTRs leads to an improvement of LV and LA morphology and a decrease in serum NT-proBNP levels.

There is no significant effect of AVF ligation on kidney allograft function: The eGFR remains stable over time.

Background

Kidney transplantation is considered as the best kidney replacement therapy, and arteriovenous fistula (AVF) is the preferred vascular access for hemodialysis. The systematic ligation of a functioning AVF in stable kidney transplant recipients (KTRs) remains debatable.

Methods

In this prospective study, we investigated the hemodynamic effect of the surgical closure of AVF in KTRs. Forty-three KTRs underwent an ambulatory BP monitoring before surgical closure of AVF (T0) and 12 months later (M12), as well as measurement of serum cardiac biomarkers (i.e., soluble suppression of tumorigenicity 2, N-terminal pro b-type natriuretic peptide [NT-proBNP], and galectin-3). Serum tests were also performed 6 months after AVF closure (M6). An echocardiographic examination was performed at each time point. All serum creatinine values were collected to compare the individual eGFR slopes before versus after AVF closure. The latest measure of the AVF flow before kidney transplantation was recorded.

Results

Diastolic BP significantly rose from T0 to M12: +4.4±7.3 mm Hg (P = 0.0003) for 24h, +3.8±7.4 mm Hg (P = 0.0018) during the day, and +6.3±9.9 mm Hg (P = 0.0002) during the night, leading to an increased proportion of KTRs with European Society of Hypertension (ESH)-defined arterial hypertension after AVF ligation. No change was observed for systolic BP. NT-proBNP significantly dropped between T0 and M6 (345 [190; 553] to 230 [118; 458] pg/ml, P = 0.0001) and then remained stable from M6 to M12 while suppression of tumorigenicity 2 and galectin-3 levels did not change from T0 to M12. We observed a significant decrease in left ventricular (LV) end-diastolic volume, LV end-systolic volume, LV mass, interventricular septum diameter, left atrial volume, and tricuspid annular plane systolic excursion from T0 to M6 and then a stability from M6 to M12. LV ejection fraction and eGFR slope remained stable during the whole study. These observations remained unchanged after adjustment for AVF flow.

Conclusion

The closure of a patent AVF in KTRs is associated with elevation of diastolic BP, drop in serum NT-proBNP levels, reduction of left ventricular and atrial dimensions, and stability of eGFR slope.

Podcast

This article contains a podcast at https://dts.podtrac.com/redirect.mp3/www.asn-online.org/media/podcast/K360/2023_12_01_KID0000000000000198.mp3
Bruner’s theory on the development of e-book traditional snacks ethnomathematics for mathematical understanding ability
Authors: Darmayanti Rani , Utomo Dwi Priyo , Choirudin Choirudin , Usmiyatun Usmiyatun , Nguyen Phong Thanh
Published: June 2023

This study aims to make traditional books that were packaged electronically with an ethnomathematics approach to traditional snacks, which was adapted from Bruner's theory by presenting three stages of Bruner's theory as enactive, iconic, and symbolic by incorporating elements of traditional snacks as an ethnomathematics approach as an effort to build students' mathematical understanding abilities. The method used the 4-D concept by using questionnaires and test instruments so that this media was valid and suitable for use as a medium in learning mathematics. The results showed a score of 3.86 for material experts and 3.74 for media experts, with 82% eligibility criteria to improve students' mathematical understanding abilities. The response to the ethnomathematics-based e-book was 91% with the "Very Eligible" criteria. It can be concluded that this e-book was developed to meet valid criteria and is practical and effective in use.
Komunikasi Interpersonal Orang Tua Bekerja dan Anak Sekolah Dasar Pada Pembelajaran Daring Selama Pandemi Covid-19
Authors: Amalia Sarah
Published: June 2023

Saat Pandemi Covid-19 pertengahan bulan Maret 2020 lalu pemerintah mengeluarkan kebijakan didalam dunia pendidikan dengan memberlakuan pembelajaran daring pada seluruh tingkatan pendidikan guna memutus rantai penyebaran virus. Kendala komunikasi yang kurang berjalan dengan baik menjadi kendala utama yang dirasakan. Penelitian ini bertujuan untuk mengetahui bagaimana proses komunikasi interpersonal orang tua bekerja dan anak sekolah dasar yang terjadi pada proses pembelajaran daring. Penelitian ini merupakan penelitian kualitatif deskriptif dengan paradigma konstruktivisme. Pengumpulan data menggunakan observasi, wawancara mendalam, dan dokumentasi. Teknik analisis data analisis dari model Miles dan Huberma dengan teknik keabsahan data yaitu triangulasi sumber. Teori yang digunakan ialah teori komunikasi interpersonal DeVito dengan kelima ciri keterbukaan, empati, dukungan, rasa positif, dan kesetaraan yang menjelaskan komunikasi yang dilakukan oleh orang tua dan anak yang telah memiliki hubungan dekat satu sama lain akan menunjang proses pembelajaran.

Hasil dapat disimpulkan bahwa secara keseluruhan ditinjau dari kelima ciri komunikasi interpersonal menunjukan bahwa orang tua bekerja dan anak mampu menjalin komunikasi yang baik dan mampu mengatasi kendala serta kesulitan yang dihadapi oleh keduanya pada saat pembelajaran daring sehingga saat melakukan pembelajaran daring dapat berjalan secara optimal
Pengaruh Kampanye #PawaiBebasPlastik2021 Terhadap Perilaku Peduli Lingkungan Followers Instagram @iddkp
Authors: Hanifah Wanda , Prananingrum Elisabeth Nugrahaeni , Sutjipto Vera Wijayanti
Published: June 2023

ABSTRACT

Since the Covid-19 pandemic, plastic problems have increased, because they are triggered by changes in behavior and consumption in the community. Environmental care behavior becomes a measuring tool to determine human behavior about the environment. Public awareness of the urgency of the issue of environmental pollution due to plastic waste is also growing, it can be seen from the emergence of various campaigns in Indonesia, thus this study aims to determine the effect of the #PawaiBebasPlastik2021 campaign on the environmental care behavior of Instagram followers iddk. This type of research is quantitative with a survey method. The number of respondents as many as 99. The results of this study indicate that the value of the correlation coefficient test is in the interval 0.61 – 0.80, this value indicates that the #PawaiBebasPlastik2021 campaign has a strong influence on the environmental care behavior of Instagram followers @Iddkp and is positive. Furthermore, based on the value of the results of the determination test, it is known that the coefficient of determination is 43.2% which shows that 43.2% of caring behavior is influenced by the campaign, but the remaining 56.8% is influenced by other factors.

Keywords: Social Media, Campaigns, Plastic Waste, Caring Behavior
EFEK KONVERGENSI MEDIA TERHADAP PEMBACA TRIBUN TIMUR
Authors: Syarif Ahmad , Arni Arni , Dewi Asri Fathia
Published: June 2023

Perkembangan teknologi informasi dari media konvensional ke media online, atau lebih dikenal dengan Konvergensi Media, menyebabkan persaingan yang ketat diantara perusahaan media untuk mempertahankan minat pembaca dan memudahkan pembaca untuk mendapatkan informasi yang diinginkan. Tujuan penelitian ini untuk mengetahui Efek Konvergensi Media terhadap Pembaca Tribun Timur berdasarkan efek kognitif, afektif, dan behavioral yang dikemukakan oleh Steven H. Chaffee. Pendekatan penelitian ini menggunakan pendekatan kualitatif dan teknik pengumpulan data dalam penelitian ini menggunakan purposive sampling. Berdasarkan hasil penelitian ini menunjukkan bahwa Konvergensi Media yang terjadi di Tribun Timur mempengaruhi efek kognitif yaitu memberikan kemudahan mengakses berita dan jangkauannya lebih luas, sehingga pembaca lebih banyak dan cepat mendapatkan informasi. Efek afektif yaitu memberikan banyak pilihan kepada pembaca mengenai konten mana yang ingin digunakan untuk mendapatkan berita. Efek behavioral yaitu menunjukkan perubahan kebiasan atau kegiatan sehari-hari dalam mendapatkan informasi lewat berita. Hal ini membuktikan bahwa adanya perubahan yang terjadi sebelum dan setelah terjadinya konvergensi media
PEMANFAATAN APLIKASI GOOGLE MEET SEBAGAI MEDIA PEMBELAJARAN PADA MAHASISWA MANAJEMEN PRODUKSI BERITA DI SEKOLAH TINGGI MULTI MEDIA MMTC YOGYAKARTA
Authors: Asiatun Siti
Published: June 2023

The Covid-19 pandemic that hit Indonesia had an impact on limiting community activities in various fields, including in education. Through a letter on the Implementation of Educational Policies in the Emergency Period for the Spread of Coronavirus Disease (Covid-19), the learning method is regulated remotely or online. Sekolah Tinggi Multi Media MMTC implements this decision by conducting theoretical and practical lectures by utilizing information technology or online. Google Meet application is one of the learning media used by students and lecturers in the news production management study program that has its advantages and disadvantages. This study aims to understand the use of the Google Meet application as a learning medium for news production management students at Sekolah Tinggi Multi Media MMTC. Qualitative method is used for this research with data obtained from direct interviews with representatives of lecturers and students of news production management. Secondary data is obtained through the Broadcasting Law, books, journals, and related articles published on the internet. It can be concluded that the overall features available in the Google Meet application make it easier for respondents to study remotely. However, this is still limited to learning about theory, not practical work.
The Effect of Citronella Oil and Sesame Oil Emulsion Coating on The Quality and Storability of Mangoes (Mangifera Indica L.)
Authors: Rahman Taufik , Suwandi Tri , Suryani Rena Adelia , Maharani Anisa , Azahra Chairani , Gunawan Gunawan , Lathifatuzzakiyyah Lu'lu' , Wahyuni N Sarah Sri , Annisa Nurul
Published: June 2023

One of the most promising agricultural commodities is the cultivation of mangoes. One way that can be used to maintain the quality and freshness of the fruit in a simple way is to do an emulsion coating. The purpose of this research was to determine the effect of citronella oil and sesame oil emulsion coating on the quality and storability of mango (Mangifera indica L.). The method used in this study was a Completely Randomized Design (CRD) with two factorial treatments and controls. The first factor was citronella oil under a concentration of 0.5% and 1%. The second factor is sesame oil under a concentration of 0.5% and 1%. The two oils were combined in the emulsion into three treatment combinations, namely S0W2, S2W0, and S1W1. The parameters measured in the observations were hardness, damage, and glucose levels in the fruit. The results showed that the level of hardness of mangoes decreased in the four treatments. Then it was found that there was an effect of delaying the maturity of the fruit with the S1W1 treatment because it was not damaged like the other treatments. While glucose levels in the fruit have increased due to the ripening process. Coating treatment with a ratio of citronella oil concentration of 0.5% to 0.5% sesame oil is the most effective treatment combination in maintaining quality and shelf life because this treatment can delay damage to mangoes.
Antioxidant Activities and Bioactive Compound in The Extract of Lobophytum sp.
Authors: Syamsu Andi Mu'nisa
Published: June 2023

This study is a descriptive exploratory research that aims to know the activity of soft coral Lobophytum sp. extract as an antioxidant. Sample extraction was done by maceration using methanol. Viscous extract obtained was then partitioned using n-hexane until gained methanol and n-hexane fraction. The chemical compositions of the methanol extract of Lobophytum sp were investigated using Gas chromatography-Mass spectrometry. The yield result of soft coral Lobophytum sp. extract is 2,59%. The weight of extract partition result were methanol fraction 8,76 g and n-hexane fraction 1,02 g. Antioxidant activity test using the 2,2-Diphenyl-1-picrylhydrazyl (DPPH) assay. Ascorbic acid was also used as positive antioxidant control. The percentage of inhibition and IC50 were measured. Antioxidant activity test which gains the best antioxidant activity is methanol fraction then followed by n-hexane fraction, both showed DPPH free radical 50% can be inhibited the activity with IC50 rate in a sequence 16,93 ppm and 30,93 ppm. GC-MS analysis, 50 kinds of chemical composition are identified in the Lobophytum sp. The results showed that the soft coral extracts of Lobophytum sp. has antioxidant activity.Keywords: soft coral (Lobophytum sp), GC-MS, fractions metahol and hexane
PELATIHAN PENGGUNAAN GAFE DAN KAHOOT SEBAGAI MEDIA PEMBELAJARAN DI SMP YPPK YOANES XXIII MERAUKE
Authors: Henukh Anderias , Simbolon Merta
Published: June 2023

The COVID-19 pandemic forces us to innovate in learning. However, the lack of awareness of teachers to use technology in learning, especially using Google Apps For Education and Kahoot as Gamification-based learning media. There is no special training related to learning using technology, especially using Google Apps For Education and Kahoot. There is not enough knowledge and skills regarding Google Docs, Google Sheets and Google Slides as a medium to work together on a virtual worksheet effectively and efficiently. Teachers still use quizzes, assignments, and written tests on paper that are printed and distributed manually to students so that they are not accustomed to working on these instruments using computers or cellphones based on Android or IOS even though this is very much needed at this time. The method used for this service activity is socialization, training, mentoring, monitoring, and evaluation. The results of the service showed that the teachers experienced an increase in knowledge and skills after participating in the service.

Keywords: Training, GAFE, Kahoot, Learning Media
PEMBENTUKAN KARAKTER DAN EDUKASI HUKUM CEGAH BULLYING PADA PELAJAR SMA NEGERI 1 MERAUKE
Authors: Rado Rudini Hasyim , Betaubun Restu Monika Nia , Badilla Nurul Widhanita Y.
Published: June 2023

As bullying behavior increases by the younger generation, especially at the educational level, it seems to confirm the increasingly crisis of character-based education in today's educational climate. This writing is directed not only to instill but also to shape character through legal education to prevent student bullying at SMA Negeri 1 Merauke, Merauke Regency. The method applied is the method of discussion, question and answer, and character building between the presenters and students. The findings of the service concluded that the degradation of the character values â€‹â€‹of students was directly proportional to the bullying behavior, this condition was exacerbated by the lack of understanding of the community and current high school students regarding the laws and regulations including the Criminal Code, the Child Protection Act, the ITE Law.
PENDAMPINGAN KESADARAN BERBANGSA DAN BERNEGARA DALAM MENINGKATKAN JIWA NASIONALISME MASYARAKAT KAMPUNG YANGGANDUR
Authors: Tambajong Hesty , Paresa Jeni , Kontu Fransin , Parukka Rachmat Agung Puank , Oja Hubertus
Published: June 2023

Yanggandur Village is a village directly adjacent to the country of Papua New Guinea, where most of the Kanum people in the village practice mixed marriages with the Kanum people who are in the country of Papua New Guinea. Judging from the culture and perspective of society which is still very limited, one step taken by the government is to strengthen education and understanding in shaping the community to become Indonesian citizens who have a national outlook and have a spirit of nationalism and love for Indonesia's homeland so that it is not easily infiltrated by other views. which can break the defense of the unity and integrity of the Indonesian state. This study aims to find out strategies about understanding the life of a good nation and state. Data collection techniques are observation, interviews, and documentation. The results of the study show that the assistance for understanding the life of the nation and state in Yanggandur Village has not run optimally. In understanding the change in mindset, society is still conservative and very passive with the situations that occur in the surrounding environment. Then fostering the spirit of nationalism, coaching needs to be improved in a sustainable manner in order to increase the spirit of nationalism, so as to form the mindset of the Indonesian people who have the spirit of Pancasila
A Knowledge Management Model to Improve Strategic Planning and Decision Making in HEIs
Authors:   Assistant Professor, Ahlia University, Bahrain, Bhaskaran Dr. Subhashini Sailesh
Published: June 2023

Knowledge management practices in Higher education institutions can lead to better decision making, better curriculum development, and research, enhanced academic and administrative services and better utilisation of resources (Kidwell et al., 2000) [6]. Moreover, the advancement in the field of Data Mining and big data science has opened up significant opportunities for these institutions to create, manage, protect and disseminate knowledge effectively. This paper presents a knowledge management model to enhance the research processes, teaching and learning processes, student and alumni services, administrative services and processes, strategic planning and management. This paper uses data mining and big data science techniques to unearth the knowledge hidden in student information systems to enable improved HEIs management and progress.
МІЖНАРОДНА ОХОРОНА ПРАВ ДИТИНИ: ДОСЯГНЕННЯ ТА ВИКЛИКИ
Authors: Предместніков Олег , Хотмірова Віта
Published: June 2023

У статті здійснено розгляд розвитку міжнародного права на захист прав дитини, досліджено  роль Організації Об’єднаних Націй та її органів у системі захисту прав дитини. Особливу увагу приділено аналізу законодавчих актів України з питань захисту прав дитини та наголошено на тому, що незважаючи на досить широкий спектр охорони прав дитини на національному рівні, Україна ще не досягла того рівня захисту, який визначений на міжнародному рівні. Охарактеризовано сучасний стан міжнародної охорони прав дитини, зокрема названо основні досягнення в міжнародній охороні прав дитини. Виділено й дві ключові проблеми, які є найбільш актуальними у сфері охорони прав дітей: застарілість окремих норм міжнародного права та – недосконалість міжнародної охорони прав дитини у збройних конфліктах. Вказано на перспективи міжнародної охорони прав дитини та можливості покращення системи захисту прав дитини в Україні.
НАСЛІДКИ ВПЛИВУ ВІЙСЬКОВИХ ДІЙ НА СТАН НАВКОЛИШНЬОГО ПРИРОДНОГО СЕРЕДОВИЩА
Authors: Войтюк Дарія , Гроза Дар’я , Єрмолаєва Тетяна
Published: June 2023

В Україні діє воєнний стан через вторгнення 24 лютого 2022 року російської федерації на територію України. За час ведення бойових дій засобами важкої наземної техніки, військової авіації, морських кораблів, ракет було вчинено воєнні злочини проти мирного населення України, завдання збитків державі, населенню та комерційному підприємству, а також через вчинені злочини відбулося погіршення стану довкілля України.У науковій статті авторами проаналізовано стан навколишнього природного середовища в Україні через застосування російської агресії на українській території.Авторами розглянуто основні фактори, які пливають на ґрунт, воду, атмосферне повітря, об’єкти природно-заповідного фонду. Визначено основні механізми захисту та покращення стану природи в Україні через бойові дії.
THE SYNERGY PARADIGM: THE POTENTIAL OF INFORMATION TECHNOLOGY IN UNIVERSITY LANGUAGE EDUCATION
Authors: Marchenko Illia , Gudkova Nataliia
Published: June 2023

The world we live in today is highly advanced in technology. Information technology has transformed many aspects of our lives, education included. At the university level, IT plays a significant role in improving the learning experience for foreign language students by providing valuable tools and resources. This article discusses how IT currently helps language learning, ways to enhance it further, and the future prospects of artificial intelligence in language study.
LEXICAL FLUENCY IN ENGLISH: CHALLENGES FOR ESP STUDENTS
Authors: Boiko Liubov
Published: June 2023

Lexical competence is a vital part of the foreign language fluency. The students who studied English as their second language and continue studying English for Specific Purposes should master not only general, but professionally-oriented vocabulary during their course of study. The paper explores various approaches to learning vocabulary and gives examples of different types of exercises which help students gain lexical competence.
НАВЧАННЯ ІНОЗЕМНИХ СТУДЕНТІВ- НЕФІЛОЛОГІВ ЧИТАННЯ ХУДОЖНЬОЇ ЛІТЕРАТУРИ
Authors: Сенік Лілія
Published: June 2023

У статті розглядається важлива методична проблема – формування у іноземних студентів умінь читання художніх творів іноземною мовою.Увага акцентується на передтекстовій лексичній роботі. Лексика розглядається с точки зору труднощів її сприйняття, зумовлених национально-культурним компонентом семантики. Пропонуються прийоми роботи, послідовність роботи з лексичними одиницями. Спеціальна робота з лексичними групами, що мають національно-культурну інформацію, допомагає глибшому розумінню художнього тексту, сприяє формуванню вмінь читання.
РОЗВИТОК ЛОГІЧНОГО МИСЛЕННЯ НА УРОКАХ З МАТЕМАТИКИ У ЗАКЛАДІ ПОЧАТКОВОЇ ОСВІТИ
Authors: Сірант Неля , Жук Лілія
Published: June 2023

У даній статті проаналізовано розвиток логічного мислення на уроках математики, адже математика займає особливе місце в освіті людини, що визначається безумовною  її практичною значущістю, та перспективами в піднесенні та правильне  формування мислень людей, їх внесок у відтворенні бачень щодо наукових методів реальності. Підкреслено, що математика   посідає основне місце та належить до частини загальної освіти, поміж усіх галузей знань, котрі генерують розуміння.
КОММУНИКАТИВНЫЕ НЕУДАЧИ В ИНТЕРНЕТ-НОВОСТЯХ
Authors: AHMEDOVA Malika
Published: June 2023

В связи с особым вниманием к коммуникативно-прагматическому направлению в науке этот аспект в интернет-новостях привлекает все большее внимание исследователей. При этом неизбежно встает вопрос не только о положительном коммуникативном взаимодействии адресанта и адресата, но и о коммуникативных неудачах. Монографического исследования этой проблемы, по нашим сведениям, нет, тем более нет и на материале узбекистанских онлайн-СМИ. В статье на примере узбекистанских и российских интернет-новостей (Газета.уз, Кун.уз, Подробно.уз, Лента.ру, Газета.ру) рассматриваются такие лингвистические аспекты коммуникативных неудач, как стилистические особенности новостей, в том числе и заголовков и лидов, использование стандартной лексики, большая длина предложений, абзацев и самих новостей. Зачастую в узбекистанских СМИ встречаются материалы, направленные на формирование положительного имиджа страны. Такие статьи пишутся официальным языком, который создает коммуникативный сбой. Российским онлайн-СМИ, судя по нашим материалам, в основном присущи такие коммуникативные неудачи, которые связаны с дословным переводом на русский язык с английского, нарушением стилистической сочетаемости.