bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGGUNAAN KONEKTIVITAS BUATAN OLEH KUKANG JAWA (Nycticebus javanicus) PADA AREAL TALUN KABUPATEN GARUT
Authors: Fauzi Hilman , Yadi Ismail Agus , Supartono Toto
Published: March 2024

Javan Slow loris (Nycticebus javanicus) is a critically endangered species caused by several factors, one of them is forest loss and sustainable habitat degradation that cause reduced the habitat of Javan slow loris. In the Agroforestry area Cipaganti Garut West Java, artificial connectivity was made by the Little Fireface Project as a solution to reduce the death threat of Javan slow loris and they can reach their home range without using terrestrial activity. This research aimed to determine the preferences of Javan slow loris to the use of 5 artificial connectivity. The data in this research were collected using camera trap which installed in each artificial connectivity and analyzed using encounter rate (ER) and Neu method to determine the encounter rate of the Javan slow loris in each artificial connectivity and vegetation analysis to determine availability of forage plant in each artificial connectivity. The Javan Slow Loris dominantly found in waterline artificial connectivity with encounter rate (ER: 3,77 pictures/day) and analyzed with Neu methods. The result is Javan slow loris prefers using the artificial connectivity (waterline) type (w1). Availability of forage plant with highest amount found on bridge 4 (waterline) with total 113 individuals from 4 speciesKukang (Nycticebus javanicus) merupakan spesies yang terancam punah yang disebabkan oleh beberapa faktor, salah satunya adalah hilangnya hutan dan degradasi habitat berkelanjutan yang menyebabkan berkurangnya habitat kukang. Di kawasan Agroforestri Cipaganti Garut Jawa Barat, konektivitas buatan dibuat oleh Little Fireface Project sebagai solusi untuk mengurangi ancaman kematian kukang dan mereka dapat mencapai wilayah jelajahnya tanpa menggunakan aktivitas terestrial. Penelitian ini bertujuan untuk mengetahui preferensi kukang terhadap penggunaan 5 konektivitas buatan. Data dalam penelitian ini dikumpulkan dengan menggunakan kamera trap yang dipasang pada setiap konektivitas buatan dan dianalisis menggunakan metode Face Rate (ER) dan Neu untuk mengetahui tingkat perjumpaan kukang pada setiap konektivitas buatan dan analisis vegetasi untuk mengetahui ketersediaan tanaman hijau. di setiap konektivitas buatan. Kukang dominan ditemukan di perairan buatan dengan tingkat perjumpaan (ER: 3,77 gambar/hari) dan dianalisis dengan metode Neu. Hasilnya kukang lebih memilih menggunakan tipe konektivitas buatan (garis udara) (w1). Ketersediaan tanaman hijauan dengan jumlah tertinggi terdapat pada jembatan 4 (garis air) dengan jumlah 113 individu dari 4 spesies
STRUKTUR POPULASI MONYET EKOR PANJANG (MACACA FASCICULARIS) DI HABITAT TERISOLASI TAMAN NASIONAL GUNUNG CIREMAI
Authors: Fajrin Musthafa , Supartono Toto , Hendrayana Yayan
Published: March 2024

This research was conducted in Cibeureum Block, which is one of the isolated habitats in Mount Ciremai National Park, West Java Province with an area of 10.42 Ha. The data collection method used in this research is the method of concentration count. Based on observations in the field, it is known that the number of groups found is 3 groups with a total population of 197 individuals, with an average individual per group of 65.67 individuals/groups. The group density value of long-tailed monkeys in Cibeureum Block is 0.29 groups/ha, while the population density value is 18.9 individuals/ha. The results of the analysis obtained are long-tailed monkeys in Cibeureum Block, Gunung Ciremai National Park, consisting of an age structure, namely 7% infant, 45% child, 27% juvenile and 21% adult with the number of each age class as follows: 14 babies. children as many as 89 individuals, adolescents as many as 53 individuals, and adults as many as 41 individuals. And for the comparison between males and females it is known from the overall sex ratio value, namely 1: 1.35. The crude birth rate was 0.26, and the crude death rate was not found in this study.Penelitian ini dilakukan di Blok Cibeureum yang merupakan salah satu habitat terisolir di Taman Nasional Gunung Ciremai Provinsi Jawa Barat dengan luas 10,42 Ha. Metode pengumpulan data yang digunakan dalam penelitian ini adalah metode penghitungan konsentrasi. Berdasarkan observasi di lapangan diketahui jumlah kelompok yang ditemukan sebanyak 3 kelompok dengan jumlah populasi 197 individu, dengan rata-rata individu per kelompok sebanyak 65,67 individu/kelompok. Nilai kepadatan kelompok kera ekor panjang di Blok Cibeureum sebesar 0,29 kelompok/ha, sedangkan nilai kepadatan populasi sebesar 18,9 individu/ha. Hasil analisis yang diperoleh adalah monyet ekor panjang di Blok Cibeureum Taman Nasional Gunung Ciremai terdiri dari struktur umur yaitu 7% bayi, 45% anak-anak, 27% remaja dan 21% dewasa dengan jumlah masing-masing kelas umur sebagai berikut: 14 bayi. anak-anak sebanyak 89 orang, remaja sebanyak 53 orang, dan dewasa sebanyak 41 orang. Dan untuk perbandingan antara laki-laki dan perempuan diketahui dari nilai sex ratio secara keseluruhan yaitu 1 : 1,35. Angka kelahiran kasar sebesar 0,26, dan angka kematian kasar tidak ditemukan pada penelitian ini.
KEANEKARAGAMAN JENIS SERANGGA PADA LAHAN TANAMAN CABAI YANG BERBATASAN DENGAN HUTAN
Authors: Firmansyah Firmasnyah , Karyaningsih Ika , Nurlaila Ai
Published: March 2024

Karangsari Village, Darma district, Kuningan Regency is one area that has agricultural land which is mostly planted with vegetable crops, the presence of pollinating insects on agricultural land in Karangsari Village is very important in helping the pollination process, resulting in the production of vegetable crops. Karangsari Village is a forest edge area in Kuningan Regency which is rich in flora and fauna that have not been identified. The problems studied in this study are 1) How is the diversity of insect species on the chili plant field 2) What is the ecological function of the insects found on the chili plant field. The method used in this research is the survey method and scan sampling. Based on observations made for 7 days, there were 7 orders, 21 families, and 26 species with ecological roles such as pests, predators, parasites, decomposers, natural enemies, and pollinators while the Shannon-Wiener index value was 2.05.Desa Karangsari Kecamatan Darma Kabupaten Kuningan merupakan salah satu daerah yang mempunyai lahan pertanian yang banyak ditanami tanaman sayuran, keberadaan serangga penyerbuk pada lahan pertanian di Desa Karangsari sangat penting dalam membantu proses penyerbukan sehingga menghasilkan produksi tanaman sayuran. . Desa Karangsari merupakan kawasan tepi hutan di Kabupaten Kuningan yang kaya akan flora dan fauna yang belum teridentifikasi. Permasalahan yang dikaji dalam penelitian ini adalah 1) Bagaimana keanekaragaman jenis serangga pada lahan tanaman cabai 2) Bagaimana fungsi ekologis serangga yang terdapat pada lahan tanaman cabai. Metode yang digunakan dalam penelitian ini adalah metode survei dan scan sampling. Berdasarkan pengamatan yang dilakukan selama 7 hari, terdapat 7 ordo, 21 famili, dan 26 spesies dengan peran ekologis seperti hama, predator, parasit, pengurai, musuh alami, dan penyerbuk sedangkan nilai indeks Shannon-Wiener sebesar 2,05.
Pengaruh Pupuk Fosfat dan Cendawan Mikoriza Arbuskula (CMA) Terhadap Pertumbuhan dan HAsil Tanaman Kacang Hijau (Phaseolus radiatus) (hal 1-14)
Authors: Nurlaila Ai
Published: March 2024

Penelitian ini bertujuan untuk mengetahui : (1) interaksi antara pupuk P dan Cendawan Mikoriza Arbuskula (CMA) terhadap pertumbuhan dan hasil tanaman kacang hijau (Phaseolus radiatus L.) varietas Walet (2) dosis pupuk P dan CMA yang memberikan hasil terbaik terhadap pertumbuhan dan hasil tanaman kacang hijau (Phaseolus radiatus L.) varietas Walet (3) korelasi antara komponen pertumbuhan dengan hasil tanaman kacang hijau (Phaseolus radiatus L.) varietas Walet.Metode yang digunakan adalah metode eksperimen dengan rancangan percobaan berupa Rancangan Acak Kelompok (RAK) pola faktorial. Penelitian terdiri dari dua faktor perlakuan, yaitu pupuk P dan CMA yang diulang sebanyak tiga kali. Faktor pertama yaitu pupuk P terdiri dari tiga taraf, yaitu : P1 (30 kg SP-36/ha), P2 (45 kg SP-36/ha), dan P3 (60 kg SP-36/ha). Faktor kedua yaitu CMA terdiri dari tiga taraf, yaitu : M1 (5 g/lubang), M2 (7,5 g/lubang), dan M3 (10 g/lubang).Hasil penelitian menunjukkan bahwa : (1) terdapat interaksi antara Pupuk P dan Cendawan Mikoriza Arbuskula terhadap parameter rata-rata tinggi tanaman umur 21 hari setelah tanam (HST), indeks luas daun umur 35 HST dan 42 HST, volume akar umur 35 HST dan 42 HST, laju pertumbuhan tanaman minggu ke-3, bobot kering per petak, bobot kering biji 100 butri dan indeks panen, (2) perlakuan pupuk P dengan dosis 45 kg SP-36/ha dan CMA dengan dosis 7,5 g/lubang menunjukkan pengaruh terbaik terhadap bobot biji kering per petak yang menghasilkan 760,57 g/petak atau setara dengan 1,14 ton/ha, (3) terdapat korelasi yang nyata antara komponen pertumbuhan tinggi tanaman umur 21 HST dan volume akar umur 35 HST dengan hasil bobot biji kering per petak.Kata kunci : kacang hijau, Cendawan Mikoriza Arbuskula (CMA), pupuk Fosfor, pertumbuhan, hasil
KEANEKARAGAMAN JENIS DAN KEPADATAN MAMALIA BESAR DI AREAL KERJA IUPHHK-HA PT. AMPRAH MITRA JAYA KALIMANTAN TENGAH
Authors: Ismail Agus Yadi , Kosasih Dede , Sulhanudin Sulhanudin
Published: March 2024

Mamalia memiliki peran penting dalam jaring makanan hampir di setiap ekosistem. Mamalia dapat memberi makan pada berbagai tingkatan rantai makanan, seperti herbivora, insektivora, karnivora dan omnivora. Penelitian ini difokuskan pada mamalia besar yang memiliki berat badan lebih dari 5 kilogram. Tujuan dari penelitian ini adalah untuk mengidentifikasi struktur vegetasi, keanekaragaman jenis dan kepadatan serta status konservasi mamalia besar yang ada di kawasan lindung IUPHHK-HA PT. AMJ Kalimantan Tengah. Penelitian dilakukan di empat kawasan lindung, yaitu Arboretum, Kantong Satwa (KS), Sempadan Sungai (SS) dan Kawasan Konservasi Insitu (KKI) dengan menggunakan metode transek garis (line transect method).Jenis-jenis tumbuhan yang ditemukan sebagian besar merupakan jenis tumbuhan yang temasuk dalam famili Dipterocarpaceae, Rosaceae, Ebenaceae, dan Leguminosae. Keanekaragaman jenis mamalia besar yang ditemukan adalah sebanyak 10 jenis mamalia. Kepadatan mamalia besar yang paling tinggi terdapat pada lokasi KS dan KKI. Dan berdasarkan jenis satwanya, yang paling tinggi adalah jenis Babi Hutan (Sus scrofa) sebanyak 2,82 individu/ha, serta Lutung Merah (Presbytis rubicunda) dan Owa-owa (Hylobates muelleri) masing-masing sebanyak 2,59 individu/ha. Hampir semua jenis mamalia besar yang ditemukan merupakan jenis satwa yang dilindungi. Dan 2 jenis diantaranya merupakan satwa yang termasuk dalam status Endangered (genting atau terancam) yaitu jenis Orang Utan (Pongo pygmaeus) dan Owa-owa (Hylobates muelleri).Agar keseimbangan ekosistem dan kelestarian alam serta lingkungannya tetap terjaga, perlu dilakukannya pengelolaan dan perlindungan yang lebih intensif baik bagi satwa tersebut maupun habitatnya sebagai penunjang keberlangsungan hidupnya.Kata Kunci : Mamalia Besar, Kawasan Lindung, Keanekaragaman Jenis Kepadatan
ANALISIS MESIN SORTASI UKURAN BIJI KOPIKAPASITAS 5 KG
Authors: Herdiana Ade
Published: March 2024

Mesin sortasi ukuran biji kopi dengan kapasitas maksimal 5kg adalah mesin pemisah ukuranukuran biji kopi sesuai dengan ukuran yang sesuai standar. Biji kopi yang dipisahkan yaitu berupa greenbean biji kopi. Biji kopi yang sudah terpisah sesuai ukuran standar dikelompokkan sesuai ukurannya dari ukuran kecil, ukuran sedang, ukuran besar bahkan hingga ukuran diluar standar. Mesin ini memiliki beberapa hal yang harus diperhitungkan dalam proses pembuatannya, diantaranya gaya dan momen yang terjadi pada mesin, daya yang dibutuhkan motor listrik, getaran yang diperlukan untuk proses sortasi ukuran biji kopi dan kecepatan efektif motor listrik yang dibutuhkan untuk proses sortasi ukuran biji kopi. Analisis yang telah dilakukan pada mesin ini diperlukan daya pada motor listrik sebesar 0.5 Hp untuk melakukan proses sortasi dengan beban grader dan biji kopi 11 kg atau Berat 110 N. Kecepatan yang dicapai motor listrik adalah 190 rpm, 230 rpm, 280 rpm, 330 rpm, dan 350 rpm dengan kecepatan efektif proses sortasi adalah 280 rpm. Getaran yang dihasilkan pada rpm tersebut yaitu 4230 getaran. Hasil dari perhitungan tersebut proses sortasi biji kopi dengan massa biji kopi 5kg dapat dipisahkan menjadi ukuran kecil,ukuran sedang, ukuran besar, dan ukuran diluar standar dengan waktu proses sortasi 15 menit. Biji kopi terpisah sesuai kategori standar yang telah ditentukan, yaitu ukuran kecil, sedang dan besar.
PERANCANGAN ALAT KEBUGARAN DENGAN FASILITAS CHARGING HP DI UNIVERSITAS GALUH CIAMIS
Authors: Herdiana Ade
Published: March 2024

Begitu pentingnya konsumsi penggunaan energi listrik bagi kehidupan manusia, hampir 60% energylistrik digunakan oleh masyarakat, mulai dari penerangan, kulkas, mesin cuci, setrika, blender, mixerdan lain-lain semuanya menggunakan konsumsi listrik. Saat ini pemerintah sedang menggalakkantentang penghematan energi listrik. Oleh sebab itu, timbul tata cara-cara pemecahan masalah tersebutyaitu dengan cara membuat energi listrik alternatif untuk mengurangi beban dari pasokan energilistrik pemerintah. Pada saat ini sepeda selain menjadi salah satu moda transportasi darat jugamerupakan jenis olahraga yang sudah menjadi gaya hidup bagi masyarakat pada umumnya. Pada saatbersepeda kita mengeluarkan banyak tenaga terutama dari ayunan tenaga kaki. Tenaga yangdikeluarkan pada saat bersepeda dapat menjadi potensi yang sangat besar untuk dikonversi menjadi energi listrik. Dikarenakan dikampus belum ada pasilitas alat kebugaran multifungsi yang dapatmenghasilkan energi untuk dimanfaatkan bila mahasiswa memerlukan untuk charger HP. Dari uraiandiatas penulis tertarik untuk melakukan penelitian dengan judul “Perancanan Alat Kebugarandengan Fasilitas Charging hp di Universitas Galuh Ciamis”. Tujuan dari penelitian ini adalahuntuk merancang alat kebugaran dengan fasilitas charging hp dengan kebutuhan energi yang sesuaibagi masyarakat kampus khususnya, Metode penelitian yang dilakukan adalah tahapan atau Mesinpengayak pupuk kompos dibuat dengan pertama-tama persiapan alat dan bahan, kemudian lakukanproses pembacaan gambar teknik, lakukan proses pemotongan profil, kemudian lakukan prosespenyambungan profil dengan menggunakan mesin Las, setelah komponen rangka jadi kemudianproses perakitan semua komponen-komponen penunjang, dan terakhir proses finishing. Kata Kunci:Mesin pengayak pupuk kompos, pupuk kompos
On the Question of Symbolist Text in M. S. Shaginyan’s Novel “Mess-Mend, or The Yankee in Petrograd”
Authors:   Independent Researcher, Rykunina Yulia A.
Published: March 2024

The article makes a number of observations on the text of the novel-tale by M. S. Shaginyan “Mess-Mend, or the Yankees in Petrograd”. The themes and motives related to the autobiographical myth of Shaginyan are revealed, for which her memoir books are involved. Thus, the novel reflects the theme of the symphony orchestra, which is the most important for the philosophical constructions of Shaginyan and for the text of her life. The author suggests that one of the heroines, whose description underwent changes in the second edition of the work, reflected the features of Zinaida Gippius, who played an important role in the biography of Shaginyan.
Falsification of Anna Akhmatova’s Manuscripts as Problem of Textual Criticism
Authors:   V. V. Vinogradov Russian Language Institute of the Russian Academy of Sciences, Moscow, Russian Federation, Druzhinin Petr A.
Published: March 2024

The article provides an overview of the falsification of Anna Akhmatova’s since the mid1990s, when the first forgeries of Akhmatova’s manuscripts appeared, up to the early 2020s. A periodization of falsifications of various types is proposed, the history of attempts to identify the forgeries and prevent their inclusion into the heritage corpus is outlined. The first forgeries of Anna Akhmatova’s manuscripts can be considered unique: these were rather attempts by falsifiers to claim the co-authorship with Akhmatova – not only through handwriting, but also through poetic creativity. That is why in the 1990s several of Akhmatova’s works, considered lost or mentioned in memoirs have resurfaced. Many scholars believed in their authenticity, and despite of being proved to be fake, these texts are still discussed in the scientific literature under the guise of originals. The second stage of the falsification of Akhmatova’s manuscripts dates back to the mid2010s, when the principles of falsification underwent serious change and at the same time have been simplified. This stage is characterized by an overt commercial orientation of falsifications, which is reflected in the content of the manuscripts and inscriptions. Specific examples demonstrate the effectiveness of literary analysis as an instrument of exposing fakes. The debatability of the authenticity of Akhmatova’s manuscripts is regarded as an actual problem of the textual criticism of the leading authors of Russian literature.
Treatment of Steroid-Resistant Beard-Restricted Alopecia Areata with Baricitinib
Authors: Zundell Melissa , Golant Alexandra
Published: March 2024

Alopecia areata is an autoimmune disorder causing localized hair loss due to T-cell attack on hair follicles. Beard involvement holds psychological and cultural significance, and treatment guidance for steroid-resistant cases is limited. We present a case of the successful treatment of steroid-resistant beard alopecia areata (BAA) with baricitinib, a JAK-1/2 inhibitor, in a 37-year-old male. Prior therapies, including topical ruxolitinib and intralesional steroids, had failed. Over 9 months, baricitinib (4 mg daily) and oral minoxidil led to reduced alopecic patches, increased hair density, and resolved inflammation. This case underscores the potential of JAK inhibitors for BAA, emphasizing the importance of establishing clear guidelines to direct treatment of in order to optimize patient outcomes.
Cutaneous Ulcerations as the Presenting Sign of Acute Aortic Occlusion
Authors: Ekeh Odera , Smith Zoë I. , Green Justin J.
Published: March 2024

This is a report of a case of acute aortic occlusion (AAO) in a 46-year-old woman who presented with confluent and coalescing punched-out ulcerations on the bilateral medial buttocks and abdominal ulcerations. This case highlights how AAO, although rare, should be considered in patients with cardiovascular risk factors presenting with acute lower extremity pain and new-onset cutaneous ulcerations of the perineum and/or abdomen.
Burnout Among Dermatology Residents and Fellows: A Survey Study
Authors: Abdelnour Alyssa , Ashack Kurt , Balk Rosie , Theunis Rushan , Miller Jeff
Published: March 2024

Background: Physician burnout is a pressing concern with substantial implications for both providers and the healthcare system. Methods: An 8-minute survey was distributed via email to members of the American Academy of Dermatology Association. Results: The survey revealed burnout is widespread among both dermatology residents and fellows. Conclusion: Residents and fellows expressed a desire for systemic changes in their working conditions.
More Than Meets the Eye: Localized Bullous Eruption After Transfusion
Authors: Malick Hamza , Lauck Kyle C. , Jalandarha Priyanka , Kivelevitch Dario
Published: March 2024

Sweet syndrome, also known as acute febrile neutrophilic dermatosis, is a neutrophilic dermatosis characterized by the presence of painful erythematous plaques and nodules with a sterile neutrophilic infiltrate on histology. However, the clinical manifestations of sweet syndrome can vary widely. Additionally, Sweet syndrome is often associated with underlying systemic diseases. In this case report, we present the case of a 72-year-old female who developed bullous sweet syndrome with oral involvement following a blood transfusion. Serology revealed an elevated pANCA level and systemic manifestations consistent with granulomatosis with polyangiitis. There have been approximately 50 reported cases of concurrent neutrophilic dermatoses occurring with ANCA-associated vasculitis. Relapse is common in these patients, with all reported cases involving the ears, nose, and throat (ENT) region. Ultimately, the concomitant presentation of ANCA-associated vasculitis and neutrophilic dermatoses is rare. Dermatologists should be aware that testing for ANCA in cases of neutrophilic dermatoses is appropriate, and if positive, close monitoring for signs of systemic vasculitis is warranted.
Spesolimab Use for Generalized Pustular Psoriasis Flare Prevention in Patients with Concomitant Plaque Psoriasis: Results from the Effisayil 2 Trial
Authors: Merola Joseph , Anadkat Milan , Bhatia Neal , Bhutani Tina , Ferris Laura , Mostaghimi Arash , Guercio .Jason , Thoma Christian , Tang Ming , Lebwohl Mark
Published: March 2024

Introduction & Objectives: Generalized pustular psoriasis (GPP) is a chronic inflammatory, potentially life-threatening skin disease, characterized by flares of sterile pustules. Spesolimab, an anti-interleukin-36 receptor monoclonal antibody, is approved to treat GPP flares in adults. Effisayil 2 (NCT04399837) evaluated the efficacy and safety of subcutaneous spesolimab in preventing GPP flares. Here, we report the effect of spesolimab versus placebo on Target Plaque Severity Score (TPSS) in patients with concomitant plaque psoriasis (PsO) in Effisayil 2.

Materials & Methods: Eligible patients with a history of GPP were randomized (1:1:1:1) to high-dose spesolimab (loading dose 600 mg, maintenance dose 300 mg every 4 weeks), medium-dose spesolimab (loading: 600 mg, maintenance: 300 mg every 12 weeks), low-dose spesolimab (loading: 300 mg, maintenance: 150 mg every 12 weeks), or placebo for 48 weeks. One PsO lesion of ≥9 cm2 with TPSS total score ≥5 and induration sub-score ≥2 was selected by the investigator at baseline for each participant. Severity of erythema, scaling, and induration (plaque thickness) of the target lesion was assessed at baseline and subsequent visits on a 5-point scale (0, none to 4, very marked), with the summation of the 3 subscores representing the TPSS total score (0-12).

Results: TPSS was measured in the 33/123 (27%) patients with PsO in the trial (9 placebo, 10 low-dose, 7 medium-dose, 7 high-dose). Mean TPSS total score was 4.2 in placebo and 4.6 in spesolimab-treated patients at baseline. By Week 4, mean TPSS remained similar in both groups (placebo, 4.3; spesolimab, 4.6). By Week 16, mean TPSS in the placebo group increased to 4.4 and decreased to 3.6 in spesolimab-treated patients. Mean TPSS total scores at Week 48 for both groups were below baseline (placebo, 3.3; spesolimab, 3.8). The number of patients with TPSS data declined in both groups over time due to GPP flare and/or early discontinuation.

Conclusion: Low baseline TPSS scores observed in this subpopulation of 33 GPP patients with concomitant PsO suggest that concomitant PsO plaque characteristics in GPP are generally mild to moderate. TPSS scores remained low and consistent throughout the trial in both dosing groups and decreases in TPSS score by Week 16 (spesolimab-treated) and Week 48 (both groups) compared to baseline were observed.
Tapinarof Cream 1% Once Daily is Efficacious in the Treatment of Mild to Severe Plaque Psoriasis in the Head and Neck Region
Authors: Stein Gold Linda , Lewitt George Michael , Lockshin Benjamin , Brown Philip M. , Tillman Katherine , Fitzgerald Nancy , Kirsch Brandon , Tallman Anna M. , Jarell Abel D.
Published: March 2024

Introduction: Tapinarof cream 1% (VTAMA®, Dermavant Sciences, Inc.) is a non-steroidal, topical aryl hydrocarbon receptor agonist approved for the treatment of plaque psoriasis in adults, with no restrictions on location, extent, or duration of use. In the phase 3 PSOARING trial program, tapinarof cream 1% once daily (QD) was efficacious and well tolerated for treating psoriasis, including the head and neck region. However, efficacy data specific to scalp treatment were not captured.Objective: To assess efficacy, safety, and tolerability of tapinarof cream for the treatment of adults with plaque psoriasis affecting the head and neck region, including the scalp. Methods: In this phase 4, open-label trial, adults received tapinarof for 12 weeks. Patients had plaque psoriasis affecting the head and neck (stable for ≥3 months), and a target lesion Physician Global Assessment (tPGA) score of 2 (mild), 3 (moderate), or 4 (severe). The primary endpoint was the proportion achieving a tPGA response (tPGA score of clear [0], or almost clear [1] and ≥2-grade improvement from baseline at Week 12). Additional endpoints included time to achieve tPGA response; proportion with complete clearance (tPGA score=0); and with ≥75% and ≥90% improvement in Psoriasis Area and Severity Index score (PASI; head and neck region). Safety and tolerability evaluations included adverse events (AEs) and investigator-assessed Local Tolerability Scale (LTS) scores. Results: 31 patients with mild to severe plaque psoriasis affecting the head and neck region received tapinarof. At baseline, 54.8% had a tPGA score of 3 and 58.1% (18/31) had the target lesion on the scalp. At Week 12, 88.5% (n=23/26) achieved a tPGA response and 80.8% (n=21/26) achieved complete clearance (tPGA=0). There was rapid onset of efficacy, with both tPGA response and complete clearance achieved as early as Week 1, the first assessment, in some patients. Median times to tPGA response and complete clearance were ~4 and 8 weeks, respectively. At Week 12, 96.2% (n=25/26) and 84.6% (n=22/26) achieved a ≥75% and ≥90% improvement in PASI (head and neck region), respectively. Most AEs were mild or moderate, consistent with previous trials; the most frequent were contact dermatitis, folliculitis, and headache. Most patients had no irritation of the head and neck region (LTS score=0) at all visits.Conclusions: Tapinarof cream 1% QD demonstrated rapid onset of clinically meaningful efficacy as early as Week 1 in patients with plaque psoriasis affecting the head and neck region, including for scalp lesions. Tapinarof cream is a cosmetically elegant, well-tolerated, non-steroidal treatment option in adults with mild to severe plaque psoriasis, including in the head and neck region.Funding Support: Dermavant Sciences, Inc.
Bimekizumab Efficacy through Year 1 in Patients with Moderate to Severe Plaque Psoriasis Who Had Not Achieved a PASI 90 Response by Week 16: A Pooled Analysis from Four Phase 3/3B Trials
Authors: Han George , Gottlieb Alice , Armstrong April , Strober Bruce , Soung Jennifer , Herr Heather , Davis Leah , Lebwohl Mark
Published: March 2024

Introduction: Psoriasis Area and Severity Index (PASI) is a commonly used tool for evaluating skin clearance; patients with ≥90% reduction from baseline PASI (PASI 90) have a level of skin clearance that has been associated with improved quality of life.1 Bimekizumab (BKZ) is a monoclonal IgG1 antibody that selectively inhibits interleukin (IL)-17F in addition to IL-17A.2 High PASI 90 response rates have been observed with BKZ, maintained through three years, across four phase 3/3b trials and an open-label extension (OLE).3–7 Here, we evaluate PASI response through Year 1 in patients who had not had a PASI 90 response during at least one visit up to and including Week 16, in four phase 3/3b trials of BKZ in moderate to severe plaque psoriasis.  

Methods: Data were pooled from the double-blinded 52-week BE VIVID,3 56-week BE READY,4 56-week BE SURE,5 phase 3 trials, and the 48-week double-blind period of the BE RADIANT6 phase 3b trial. Included patients were randomized to BKZ 320 mg every 4 weeks (Q4W) to Week 16 and then received either BKZ 320 mg Q4W or Q8W maintenance dosing until end of Year 1 (Week 52 for BE VIVID; Week 48 for other trials). Results are reported as observed case (OC).

Results: Of the 1,362 patients randomized to BKZ across four phase 3/3b trials, 92.6% (n=1,261) had a PASI 90 response during at least one visit up to and including Week 16 while 7.1% (n=97) had not. PASI response was unavailable for 4 patients. The median (minimum, maximum) percent change from baseline PASI among the 97 patients without a PASI 90 response by Week 16 was −77.3 (−89.7, +20.0) at Week 16 (n=78) and −92.9 (−100, +90.7) at Year 1 (n=51).

Overall, 61.9% (60/97) of patients without a PASI 90 response by Week 16 completed their respective phase 3/3b trials and entered an OLE. By Year 1, 55.0% (33/60) achieved PASI 90 during at least one visit.

Conclusion: While the vast majority (92.6%) of patients treated with BKZ had a PASI 90 response during at least one visit up to Week 16, a large proportion of patients without a PASI 90 response by Week 16 who completed the phase 3/3b trials and entered an OLE had a PASI 90 response during at least one visit up to Year 1 (55.0%).
Efficacy of Abrocitinib and Dupilumab in Patients With Moderate-to-Severe Atopic Dermatitis With Severe Itch at Baseline and in Subgroups by Baseline Thresholds of Severe Itch: A Post Hoc Analysis of the JADE COMPARE and JADE DARE Clinical Trials
Authors: Hong H. Chi-Ho , Gooderham Melinda , Kwatra Shawn , Gregoriou Stamatios , Yosipovitch Gil , Biswas Pinaki , Selfridge Andrew , Koulias Christopher , Güler Erman
Published: March 2024

Introduction: In phase 3 trials, abrocitinib provided more rapid and greater itch relief than dupilumab in patients with moderate-to-severe atopic dermatitis (AD). We examined the efficacy of abrocitinib versus dupilumab in patients with severe itch at baseline (BL) and in subgroups by BL thresholds of severe itch.Methods: Data were pooled from patients treated with abrocitinib 200 mg or dupilumab 300 mg in JADE COMPARE (NCT03720470) and JADE DARE (NCT04345367). Patients with severe itch at BL (Peak Pruritus Numerical Rating Scale [PP-NRS] ≥7), and subgroups by BL PP-NRS 7-10 were assessed for achievement of ≥4-point improvement in PP-NRS (PP-NRS4) and PP-NRS 0/1 (itch free state). Subgroups were also assessed for achievement of Patient Oriented Eczema Measure (POEM) score ≤2 (clear/almost clear AD), and Dermatology Life Quality Index (DLQI) score of 0/1 (no impact on quality of life [QoL]).Results: This analysis comprised 875 patients (abrocitinib, 453; dupilumab, 422) with severe itch at BL. Median (Q1, Q3) BL score for PP-NRS was 8.0 (7.0, 9.0) in the abrocitinib arm and 8.0 (7.0, 9.0) in the dupilumab arm; 22.0 (19.0, 26.0) and 22.0 (19.0, 27.0) for POEM; 16.0 (11.0, 20.5) and 16.0 (11.0, 20.0) for DLQI. In the overall group, PP-NRS4 responses were greater with abrocitinib versus dupilumab as early as week 2 (56% vs 32%) and sustained through week 16 (73% vs 69%). Stringent PP-NRS 0/1 responses were greater with abrocitinib versus dupilumab at weeks 2 (15% vs 3%) and 16 (35% vs 21%). Across patient subgroups by BL PP-NRS 7-10, greater proportions achieved PP-NRS4 and PP-NRS 0/1 with abrocitinib versus dupilumab at weeks 2 and 16. Greater proportions across subgroups achieved POEM ≤2 with abrocitinib compared with dupilumab at week 16 (BL PP-NRS7, 33% vs 10%; BL PP-NRS8, 29% vs 20%; BL PP-NRS9, 39% vs 16%; BL PP-NRS10, 31% vs 23%). In the overall group, greater proportions achieved DLQI 0/1 with abrocitinib versus dupilumab at weeks 2 (19% vs 6%) and 16 (38% vs 27%). Across subgroups, DLQI 0/1 responses with abrocitinib were generally greater than dupilumab at weeks 2 and 16.Conclusions: In patients with moderate-to-severe AD who had severe itch at BL, abrocitinib provided more rapid and complete/near complete itch relief and improved QoL than dupilumab as early as 2 weeks of treatment. These results were consistent across subgroups by various BL thresholds of severe itch.
Diagnostic Discordance Among Histopathological Reviewers for Difficult-to-Diagnose Melanocytic Lesions
Authors: Hosler Gregory , Goldberg Matthew , Estrada Sarah , O'Neil Brendan , Amin Sapna , Plaza Jose
Published: March 2024

Purpose: Histopathological examination is adequate for most melanocytic neoplasms. However, there is a subset of lesions with uncertain malignant potential that are difficult-to-diagnose where utilization of ancillary tests may be considered to aid in providing a more definitive diagnosis.

Study design: Under an IRB-approved protocol, 3,317 melanocytic lesions underwent independent diagnostic review by up to 9 unique board-certified dermatopathologists. Each lesion received ≥ 3 diagnoses via electronic whole slide images with zoom-in capability as benign, malignant, or unknown malignant potential (UMP). Lesions were subsequently binned according to the results of dermatopathology review in the following manner: concordant (all diagnoses of the same designation); conflicting (both benign and malignant designations); majority (a single designation with the highest number of diagnoses); and equivocal (equal number of different designations). Here we describe the identification of lesions suitable for ancillary testing.

Results: 30% of lesions were concordant benign and 46.3% were concordant malignant, indicating 76.3% of all lesions were not difficult-to-diagnose. 23.7% of lesions had some level of diagnostic difficulty and/or ambiguity defined by disagreement between reviewers and would be suitable for ancillary testing. Within these ~24%, 7.3% of lesions were majority benign, 4.8% of lesions were majority malignant, 2.7% were majority UMP, 6.9% of lesions were conflicting, and 1.6% of lesions were equivocal.

 

Conclusions: We demonstrate that in a large cohort of suspicious pigmented lesions, ~24% were difficult-to-diagnose, supporting the need for additional objective diagnostic tools. Patient care would benefit from ancillary testing to aid the diagnosing pathologist in identification of the most appropriate diagnosis to optimize patient management.

Potential conflicts of interest: This study was supported by Castle Biosciences, Inc. GAH and JAP have served as consultants for Castle Biosciences, Inc. MSG is an employee shareholder of Castle Biosciences, Inc. SIE is a consultant and shareholder for Castle Biosciences, Inc. Editorial assistance was provided by Brooke H. Russell, PhD, and Jason H Rogers, MSc, both employee shareholders of Castle Biosciences, Inc.
A New Peptide Skin-Brightening Facial Cream Demonstrated Clinical Improvement in Jawline Sagging, Discoloration and Overall Photodamage
Authors: Edison Brenda , Feng Li , Singh Surabhi , Guerrero Ritamarie , Parsa Ramine , Patel Ruchi , Dufort Marisa , Green Barbara
Published: March 2024

Besides fine lines and wrinkles, chronological aging leads to discoloration, age spots, and more importantly, sagging and loss of elasticity on facial skin. There are ample consumer needs to reduce age spots and skin sagging with an increasing desire for effective topical solutions that can provide meaningful benefits in these areas. A new microdipeptide (acetyl dipeptide) technology was developed that demonstrated the potential to reduce skin inflammation and stimulate the skin’s supporting matrix. This clinical study was designed to test the effectiveness of a facial cream with a unique blend of microdipeptide technology along with brightening and firming ingredients to reduce the key signs of facial aging with twice daily use. The 16-week study included 43 healthy female subjects, ages 40-70 with diverse skin tones, and having mild to moderate jawline sagging with fine lines and/or hyperpigmentation by expert visual grading (3 to 6 on a 0 to 9 scale). Visual grading exhibited statistically significant reduction in all targeted skin aging signs starting at week 8, and continuing improvement to week 16, including jawline sagging (19%), laxity (19%), lift/ firmness (15%), as well as improved evenness of skin tone (16%), hyperpigmentation (14%) and overall photodamage (23%) (mean percent change, p< 0.05). Consumer perception questionnaires also revealed improvement after 16 weeks of use with tighter/tauter jawlines (88%), increased firmness (93%), skin elasticity (93%), refined facial contour (88%), less sagging (95%), and more lifted (91%) and volumized appearance (98%). Furthermore, subjects also indicated brighter skin (95%), increased radiance (93%), less discoloration (86%), fading dark spots (77%), reduced fine lines (93%) and wrinkles (95%), skin looks younger (95%), and overall less noticeable aging signs (95%). Clinical photography supported both the clinical grading and consumer perception of benefits.  In addition, these clinical outcomes are further supported by in vitro and ex vivo investigations showing the microdipeptide activity on inhibiting the expression of inflammatory cytokines and inducing multiple matrix building biomarkers, beyond elastin, pro-collagen and hyaluronic acid to include decorin and fibronectin. Gene expression profiling showed changes associated with skin barrier and extracellular matrix organizations, therefore mimicking a younger-looking skin. These results demonstrated that this peptide facial cream was well-tolerated and effective in improving jawline sagging, facial skin firmness, skin brightening, and reducing the overall signs of aging.
VP-102 Tolerability Evaluated by Concomitant Analgesic Medication Usage in Two Phase 3 Trials for Molluscum Contagiosum
Authors: Siegfried Elaine , Eichenfield Lawrence , Kwong Pearl , Sugarman Jeffrey , Cutler Susan , Goldenberg Gary
Published: March 2024

Background: Drug tolerability is the degree to which a patient can tolerate a drug's adverse effects. VP-102, a drug-device combination product containing cantharidin (0.7%), a vesicant, is approved for treatment of molluscum contagiosum (molluscum) in patients >2. Local skin reactions (LSRs) are expected, including pain.  In Phase 3 trials, 97% of LSRs were mild to moderate. The discontinuation rate due to an adverse reaction was 2.3%:0.5% (drug:vehicle) treated subjects, respectively. This post-hoc analysis evaluated VP-102 tolerability based on analgesic usage over the study course.

Methods: VP-102 or vehicle was applied to all baseline and new lesions once every 21 days until complete clearance, or up to a maximum of 4 applications. Acetaminophen or ibuprofen were permitted for application site pain and/or other Adverse Reactions.

Results: Overall incidence of pain at any time for a VP-102 subject was 62.7% (195/311), with the majority [(60.5%),188/311] as mild to moderate. 18.6% (58/311) of VP-102 and 1.4% (3/216) of vehicle treated subjects received an analgesic, including 15.8% (49/311) for an LSR after the first VP-102 application.

 

Median VP-102 analgesic use for LSR pain (range) was 2 (1-14) days for the entire study, and 2 (1-9) days after the first application.  29% of participants who reported analgesic usage took medication ≤1 day.  Analgesic usage for AEs other than LSR pain (≥ 5% of participants) included 6% (19/311) for application site vesicles. There were no treatment-related SAEs reported.

 

Conclusions: In this largely pediatric population, VP-102 was well-tolerated, with a short duration of elective analgesic use.
Roflumilast Cream 0.3% for the Treatment of Recalcitrant Lichen Nitidus
Authors: Galimberti Fabrizio , Li Yumeng
Published: March 2024

Introduction:

Lichen nitidus is a rare chronic inflammatory condition that presents as shiny, flat-topped papules. The pathophysiology of lichen nitidus is not well understood but has been theorized to stem from allergens that cause antigen presenting cells to activate, thus causing a cell-mediated response that ultimately creates the distinct inflammatory papules1. Cytokines produced by this cell-mediated response may cause an increase in T-helper 2 cells which have the potential to produce the superficial dermal granulomas seen in lichen nitidus2.  Currently, no FDA approved treatments for lichen nitidus exist. Due to the inflammatory nature of the disease, off-label therapies may include topical corticosteroids, topical calcineurin inhibitors and UV light1. Lichen nitidus can be a chronic condition and in cases where long term topical corticosteroid use is required, has been associated with hypopigmentation in African Americans. Roflumilast cream 0.3% is a highly selective, non-steroidal and potent topical phosphodiesterase 4 (PDE4) inhibitor approved in 2022 by the FDA for the treatment of psoriasis, including intertriginous disease. Here, we report the case of a 51-year-old African American patient with lichen nitidus that is pruritic and refractory to typical off-label treatments including emollients, triamcinolone and clobetasol. The patient was started on roflumilast cream 0.3% daily with complete resolution of lesions and pruritus in 4 weeks.

 

Case Report:

We report the case of a 51-year-old African American patient presenting to the clinic with a history of firm, pruritic, white colored papules on both of his hands that made it hard for him to drive. These lesions had been present for 2 years and did not respond to previous treatment with emollients and topical corticosteroids including triamcinolone cream 0.1% and clobetasol ointment 0.05% both twice daily. A biopsy was performed and demonstrated lymphocytic infiltrate in the upper dermis and the classic “claw and ball” configuration consistent with lichen nitidus. The patient was subsequently started on topical roflumilast 0.3% daily which resulted in complete resolution of lesions and pruritus within 4 weeks.

 

Conclusion:

We reported a case of a 51-year-old African American papules on both hands that were consistent with lichen nitidus. In this case, the patient’s lichen nitidus was refractory to topical corticosteroids and emollients. Long term corticosteroid use is also associated with hypopigmentation in this population. After starting topical roflumilast 0.3% daily, the patient reported complete resolution of the lesions and puritus. This report suggests reduction of inflammation with roflumilast cream 0.3%, can offer a treatment option for patients with lichen nitidus.
The Contribution of EFL Students’ Vocabulary Mastery and Motivation to Writing Ability of Eighth-Grade Students at Smpn 5 Denpasar
Authors: Puspitasari Made , Ratminingsih Ni Made , Santosa Made Hery
Published: March 2024

The ability to compose written messages in words, sentences, texts, and coherent words that readers can understand is known as writing ability. The objectives of this research were first to investigate how much the contribution of vocabulary mastery to writing ability, the second was to investigate how much the contribution of motivation to writing ability, and the third was to investigate how much the contribution of vocabulary mastery and motivation simultaneously to writing ability. This study was designed in the form of correlational research design. The population of this study was the eighth-grade students at SMPN 5 Denpasar. In this study, 149 students served as samples. They were chosen using a proportionate random sampling technique. Test of Multiple choice was for vocabulary mastery, questionnaire was for motivation and test of writing assignment was for writing ability, those were utilized to gather the data for this study. With the use of SPSS 26.0, linear and multiple regression analyses were performed on the data. The findings showed that there was high and significant contribution of vocabulary mastery to writing ability. The contribution of vocabulary mastery to writing ability was 69%, and there was high and significant contribution of motivation to writing ability. The contribution of motivation to writing ability was 70.5%. Moreover, the contribution of vocabulary mastery and motivation simultaneously to writing ability was 79.9%. It indicates that there was high and significant contribution of vocabulary mastery and motivation simultaneously to writing ability of eighth grade students of SMPN 5 Denpasar.
Modeling the financial stability of universities in Russia: analysis of the impact of government financing and external sources of income
Authors: Успаева М.Г. , Гачаев А.М.
Published: March 2024

В эпоху трансформации высшего образования в России финансовая устойчивость университетов представляет собой многоаспектную проблематику, требующую детального анализа. Вузы сталкиваются с необходимостью адаптации к меняющимся экономическим условиям, где государственное финансирование и внешние источники дохода играют ключевую роль. Материалы и методы. Исследование базируется на анализе статистических данных, охватывающих период с 2010 по 2023 год, отражающих динамику государственного финансирования и внешних источников дохода вузов. Применены качественные и количественные методы анализа, включая корреляционный анализ и моделирование, для выявления зависимостей и определения ключевых факторов, влияющих на финансовую устойчивость университетов. Результаты. Анализ показал, что в период с 2010 по 2023 год произошло существенное увеличение государственного финансирования вузов, с ростом с 280 млрд рублей в 2010 году до 450 млрд рублей в 2023 году. Вместе с тем, наблюдалось увеличение доли внешних источников дохода, таких как платные образовательные услуги и научные гранты, с 35% до 60% от общего бюджета университетов. Корреляционный анализ выявил значительную положительную связь между уровнем государственного финансирования и показателями академического успеха вузов.

In the era of transformation of higher education in Russia, the financial stability of universities is a multidimensional issue that requires detailed analysis. Universities face the need to adapt to changing economic conditions, where government funding and external sources of income play a key role. Materials and methods. The study is based on the analysis of statistical data covering the period from 2010 to 2023, reflecting the dynamics of public financing and external sources of income of universities. Qualitative and quantitative analysis methods, including correlation analysis and modeling, have been applied to identify dependencies and identify key factors affecting the financial stability of universities. Results. The analysis showed that in the period from 2010 to 2023, there was a significant increase in state funding for universities, with an increase from 280 billion rubles in 2010 to 450 billion rubles in 2023. At the same time, there was an increase in the share of external sources of income, such as paid educational services and research grants, from 35% to 60% of the total budget of universities. The correlation analysis revealed a significant positive relationship between the level of government funding and indicators of academic success of universities.
Designing and Developing E-Magazine about Indonesian Cultural Concept in Social Studies Learning for Elementary School Students
Authors: Septyani Hannifah Dwi , Mulyati Tita , Wahyuningsih Yona
Published: March 2024

The background of this research is optimizing material on cultural diversity, cultural tourism and special food in Indonesia in class IV SD in social studies learning through the digital media e-magazine Anak Bangsa. The use of the Anak Bangsa e-magazine learning media is due to the lack of use of learning media during the teaching and learning process and a decrease in love for preserving culture. This study aims to produce a product in the form of an e-magazine Anak Bangsa learning media on cultural diversity material in Social Studies class IV SD. This research uses the Design and Development method with the ADDIE model (Analysis, Design, Development, Implementation, Evaluation). The instruments used were questionnaires for validating material experts, media experts, and linguists, questionnaires for teacher and student responses, as well as interviews with educators and students. The research produced the product of Anak Bangsa e-magazine learning media with material on cultural diversity in grade IV SD. The results of the recapitulation of the feasibility test through validation by experts namely material experts, media experts, and language experts using a validation questionnaire obtained the category "Very Eligible". The results of the assessment recapitulation from the responses of educator users and students obtained the "Very Eligible" category. The learning media for the Anak Bangsa e-magazine on social studies material on cultural diversity that has been developed is suitable for use as an alternative media for learning social studies in grade IV elementary schools.Keywords: E-Magazine, Learning Media, Social Studies Learning in Elementary Schools