bluuebunny/crossref_metadata_2025 huggingface dataset:
Carotenoids in the treatment of age-related macular degeneration: a drug delivery system does matter
Authors:   Kazan State Medical Academy — Branch of the Russian Medical Academy of Continuous Professional Education, Kazan, Russian Federation, Maksimov M.L. ,   Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation,   Pirogov Russian National Research Medical University, Moscow, Russian Federation, Oganezova J.G. ,   Pirogov Russian National Research Medical University, Moscow, Russian Federation,   Research Center for Medical Genetics, Moscow, Russian Federation, Kanner I.D. ,   Lomonosov Moscow State University, Moscow, Russian Federation, Voznesenskaya A.A. ,   National Medical Research Center of Endocrinology, Moscow, Russian Federation
Published: March 2023

Age-related macular degeneration (AMD) is one of the leading causes of low vision and blindness worldwide for people over age 60. By 2040, the number of people living with macular degeneration is expected to reach 288 million due to the exponential acceleration of population aging. A decline in visual functions caused by AMD has a significant economic impact in all countries. Besides aging, there are other multiple heterogenic risk factors associated with AMD: gender, environmental condition, lifestyle, genetic characteristics, chronic inflammatory processes in the human body, level of education, etc. It is important for the ophthalmologist to be aware of modifiable risk factors and thus to collect a comprehensive medical history, interact with patients using motivational interviewing and to involve promptly other healthcare specialists into the patient management strategy. Etiopathogenesis of AMD is still not entirely understood. However, it is known that the major pathways include age-related alterations of retinal pigment epithelium (RPE) cells, oxidative stress, dysregulated lipid metabolism, inflammation, hemodynamic changes, and neovascularization. Carotenoids lutein and zeaxanthin are natural compounds with a proven efficacy in reducing AMD progression, which have been demonstrated to act as medications for patients with early AMD stages. The micro- encapsulated formula offers such an advantage as gradual and controlled release of active substances. Keywords: age-related macular degeneration, risk factors, etiopathogenesis, carotenoids, lutein, zeaxanthin, microcapsules. For citation: Maksimov M.L., Oganezova J.G., Kanner I.D., Voznesenskaya A.A. Carotenoids in the treatment of age-related macular degeneration: a drug delivery system does matter. Russian Journal of Clinical Ophthalmology. 2023;23(1):60–65 (in Russ.). DOI: 10.32364/2311-7729-2023-23-1-60-65.
Smart Helmet As Driving Safety
Authors: Kusumastuti Sri , Widi Sasono Sindung Hadwi
Published: March 2023

One of the common causes of accidents is physiological factors such as drowsiness. A helmet is a device used to reduce the risk of head injury when an accident occurs while driving. Helmets placed on motorbikes often experience theft to the detriment of the helmet owner. A helmet was created to reduce the risk of an accident, warn motorists when they are drowsy, and provide a warning when a helmet is stolen. The method begins with designing devices, preparing devices, testing, repairing, and adjusting devices. The main components used are Arduino Nano and Arduino Pro Mini. The input components are a pulse sensor, MPU6050 sensor, touch switch, NRF24L01 receiver, rope clip, on/off push button, and limit switch. The output components are one channel relay, NRF24L01 transmitter, and speakers. From the results of testing the device, the helmet will be connected to the motorbike if appropriately used, the speaker will send a rest notification if the rider is drowsy, and the helmet alarm will sound loud when someone wants to steal the helmet.
A qualidade do sono e o processo de ensino-aprendizagem: um estudo de caso com estudantes baianos
Authors: Quintino Edivan Santana , Souza Diogo José Oliveira , Silva Américo Junior Nunes da
Published: March 2023

O sono é uma condição fisiológica natural do organismo humano, e exerce funções como: restaurar o sistema neurológico, modular a cognição, consolidar a memória e a aprendizagem e contribuir psicologicamente para o bem-estar mental das pessoas. Diante disso, foi desenvolvida uma investigação durante o Estágio Curricular Supervisionado II, do curso de Licenciatura em Ciências Biológicas, com o objetivo de identificar as causas que comprometem a qualidade do sono de estudantes do Ensino Médio/Técnico e as suas principais consequências para o processo de ensino-aprendizagem. A pesquisa foi desenvolvida em duas turmas de 1° ano de um curso Técnico em Agropecuária de um Instituto Federal localizado na Região Norte do Estado da Bahia. Utilizou-se, para o movimento de produção de dados, um formulário do Google Docs, do qual participaram 40 alunos. Após análise, percebeu-se que as condições socioeconômicas e psicológicas dos estudantes, a infraestrutura da escola, o uso de tecnologias e o número de atividades solicitadas pelos docentes são as principais causas que interferem na qualidade do sono dos discentes. Desta forma, os adolescentes investigados possuem baixa duração do sono, o que remete à necessidade de intervenções.
МУЗИКА У ХАРКІВСЬКОМУ ДЕРЖАВНОМУ АКАДЕМІЧНОМУ ТЕАТРІ ЛЯЛЬОК ІМЕНІ В. А. АФАНАСЬЄВА: ІСТОРІОГРАФІЧНИЙ ТА ФЕНОМЕНОЛОГІЧНИЙ АСПЕКТИ
Authors: ПАЛАЧОВА Катерина
Published: March 2023

Актуальність теми зумовлена відсутністю в сучасному музикознавстві спеціальних наукових досліджень, присвячених музиці у театрі ляльок, та розкривається через затребуваність дослідження й увиразнення ролі музики, що становить невід’ємну складову лялькової вистави як художньої цілісності. Метою наукової статті є виявлення специфіки функціонування музики у виставах Харківського державного академічного театру ляльок імені В. А. Афанасьєва в історичному дискурсі; в тому числі – на конкретному прикладі виявити роль музики у новітній постановці театру. Методологія дослідження заснована на поєднанні історичного, структурно-функціонального, семантичного, жанрово-стилістичного, системного підходів. Вперше у науковій практиці здійснено історичний огляд репертуару Харківського театру ляльок саме з точки зору функціонування музики у його виставах. Виявлено, що від початку своєї історії театр був і є носієм традицій співпраці режисерів із композиторами Харківської школи, і, водночас, – платформою для творчих пошуків та експериментів, які вивели театр на новий рівень на початку ХХІ століття. Новітній період історії театру (з 2007 року до сьогодення) пов’язаний з виставами головної режисерки Оксани Дмітрієвої і відзначений принциповим підходом до процесу музичного оформлення вистави: музика постає невід’ємною вагомою складовою загальносценічного дійства та носієм семантичних кодів до осмислення художньої ідеї вистави. На прикладі аналізу музичного рішення новітньої постановки Харківського театру ляльок визначено ті ключові компоненти, які формують звуковий образ вистави: це система музичних характеристик персонажів, вибір музичних тембрів як носіїв певної семантики, звуки-шуми, які виконують звукозображальну функцію. Досвід функціонування музики у виставах у Харківському театрі ляльок засвідчує роль композитора, який є повноправним учасником постановочного процесу разом із режисером і художником.
BAI'UL WAFA` (Review Penggunaan Dalil Mashlahah di Kalangan Hanafiyah)
Authors: Asa'ari Asa'ari
Published: March 2023

Ba'i al-Wafa` first appeared in Central Asia, especially Bukhara and Balkh around the 5th century AH in order to avoid usury in borrowing. Many of the rich when it is not willing to lend money without any remuneration they receive. While many of the borrowers are not able to pay off debts due in return they have to pay along with money borrowed. On the other hand benefits granted on the basis of borrowing money, according to scholars of fiqh including usury. So to avoid usury, the community of Bukhara and Balkh formatting a form of trading known as alWafa` Bai'u. For today's economic context Bai'ulWafa` should be considered to be applied in the activities mu'amalatMuslim community, especially in Indonesia as a substitute for Pawn institutions that practice during this conflict with Rahan outlined by the texts, especially in terms of taking advantage of pledges by the lien holder Bai'u al-Wafa` muncul pertama kali di Asia Tengah khususnya Bukhara dan Balkh sekitar abad ke 5 Hijriyah dalam rangka menghindari terjadinya riba dalam pinjammeminjam. Banyak di antara orang kaya ketika itu tidak mau meminjamkan uangnya tanpa ada imbalan yang mereka terima. Sementara banyak pula para peminjam uang tidak mampu melunasi hutangnya akibat imbalan yang harus mereka bayarkan bersamaan dengan uang yang dipinjam. Di sisi lain imbalan yang diberikan atas dasar pinjam-meminjam uang itu menurut ulama fikih termasuk riba. Maka untuk menghindarkan diri dari riba, masyarakat Bukhara dan Balkh memformat suatu bentuk jual beli yang dikenal dengan Bai'u al-Wafa`. Untuk konteks ekonomi dewasa ini, Bai'ul Wafa` patut dipertimbangkan untuk diterapkan dalam aktivitas mu'amalat masyarakat Muslim khususnya di Indonesia sebagai pengganti institusi Gadai yang praktiknya selama ini bertentangan dengan Rahan yang digariskan oleh nash terutama dalam hal mengambil manfaat dari barang gadaian oleh pemegang gadai.
AN INVESTIGATION OF INDONESIAN EFL TEACHERS’ PERCEPTION OF COMMUNICATIVE LANGUAGE TEACHING
Authors: Daflizar Daflizar
Published: March 2023

Over the past three decades, the Communicative Language Teaching (CLT) has become one of the most dominant approaches in the field of ESL or EFL teaching in many countries around the world, including Indonesia. The aims of this study were threefold: (a) to investigate Indonesian EFL teachers’ theoretical perceptions of CLT, (b) to look at whether the teachers have implemented CLT in the classroom, and (c) to identify difficulties the teachers face in implementing CLT. The participants in the study were 7 Indonesian EFL teachers who were pursuing their study in TESOL and Foreign Language Teaching program at the University of Canberra. Thirty-item questionnaires were used for data collection. The results of the study revealed that the teachers involved in this study generally had considerably good understanding of principles and activities of CLT. Most of the teachers also reported thatthey have implemented CLT in their classrooms even though many of them still maintained activities of traditional approaches. The results also revealed that all of the teachers face some constraints in implementing CLT activities in their classrooms. Among the most common constraints include low English proficiency of the students, large classrooms, and lack of sources.
Discussion on the Scientific Research Cooperation Network of Local Colleges and Universities -- Based on the Perspective of Knowledge Governance
Authors: Zhang Xiaoqin
Published: March 2023

In recent years, many scholars at home and abroad have carried out relevant research work on scientific research cooperation, but the social network analysis method is commonly used, and the literature on research cooperation network of local universities is relatively small and lacks a systematic theory. Taking knowledge governance as the basic perspective, we analyze the existing research on scientific research cooperation, carry out the analysis of the necessity and feasibility of establishing scientific research cooperation network in colleges and universities, and take 10 colleges and universities in Fujian Province as samples to explore the existing problems of scientific research cooperation network in local colleges and universities, so as to provide theoretical support and new perspectives for the level of scientific and technological innovation and service capability of colleges and universities to enhance the competitiveness of college education.
Effect of progovernmental pre-electoral violence upon electoral outcome
Authors: Andersson Robert
Published: March 2023

Electoral violence can have dire consequences for a society, but remains a strategy employed by incumbents to secure electoral victory. This paper explores if electoral violence instigated by progovernment side actually does increase the incumbent’s probability of electoral victory. The novelty of the question derives from taking into account a differentiation between the instigating side as progovernment or anti-government, which previous studies have not done. The argument is that as the opposition is likely to have other motives and resources available than the incumbent, anti-government violence should target other spectrums of the population and thus have a different effect on the electoral outcome than progovernment violence. 

The findings give consistent statistical significance to a positive relationship between progovernment instigated violence and probability of incumbent electoral victory when controlling for electoral fraud and anti-government violence. This supports the hypothesis and suggests that incumbents do benefit, at least in the short term, from applying electoral violence. However, long-term backlash may still occur and the consequences for the society are dire. The relationship between anti-government violence and electoral outcome did not achieve statistical significance. Further research are needed to improve the nuance of the findings in this paper and better understand electoral violence from different actors’ perspectives.
Intersectional Identities and Land Dispossession
Authors: Tveitnes Homme Sunniva
Published: March 2023

Land grabbing has long been present in Southeast Asia, but with the spike in commodity prices in 2008, land grabbing intensified. The procedure is highly problematic as it often occurs at the expense of peasant farmers, land stewardship, food sovereignty, and human rights. So far, the literature has paid insufficient attention to the vulnerability of indigenous women and their intersectional vulnerability of gender and ethnicity when facing land dispossession. Such neglect poses far-reaching analytical limitations and questionable political implications. It is essential to bridge the gap between land-grabbing studies and the gendered implications of land dispossession on indigenous women to generate more nuanced analyses of the issue. Through a qualitative in-depth comparative analysis of the general implications of land dispossession on indigenous women in Southeast Asia and two case studies of the Cordillera Administrative Region in the Philippines and Kalimantan in Indonesia, the paper tries to answer how does the gendered politics of land dispossession affect indigenous women? It finds that indigenous women have higher physical and economic vulnerabilities due to land dispossession than non-indigenous women. These vulnerabilities are further heightened due to the lack of representation in decision-making. However, how these vulnerabilities play out highly depends on national and local factors.
ОСОБЛИВОСТІ ФОРМУВАННЯ УЯВЛЕНЬ ПРО НАВКОЛИШНІЙ СВІТ У МОЛОДШИХ ШКОЛЯРІВ З ПОРУШЕННЯМИ РОЗУМОВОГО РОЗВИТКУ
Authors: Хайдарова Оксана
Published: March 2023

У статті розкрито актуальність питання формування уявлень про навколишній світ у молодших школярів з помірною розумовою відсталістю. Проведено аналіз спеціальної літератури та розглянуто підходи вчених до даного питання. Для дітей з помірною розумовою відсталістю головним залишається соціальна адаптація, тому актуальною є проблема створення оптимальних умов для формування життєвої компетентності та адекватного відношення до природи, людини. Правильно сформовані уявлення про навколишній світ сприяють кращій соціальній адаптації та розвитку життєвих компетентностей.
АНАЛІЗ ЗАРУБІЖНИХ ПРАКТИК СОЦІАЛЬНО-ПЕДАГОГІЧНОЇ ПІДТРИМКИ БАТЬКІВ ДІТЕЙ З ОСОБЛИВОСТЯМИ ПСИХОФІЗИЧНОГО РОЗВИТКУ
Authors: Чечко Тетяна
Published: March 2023

Метою статті є здійснення теоретичного аналізу зарубіжних практик соціально-педагогічної підтримки батьків дітей з особливостями психофізичного розвитку. Методами дослідження стали: спостереження, порівняння, абстрагування, аналізі синтез, індукція і дедукція. В результаті дослідження узагальнено особливості надання соціально-педагогічної підтримки батькам дітей з особливостями психофізичного розвитку дошкільного віку в різних країнах; визначено особливості роботи та завдання служб раннього втручання. Практичне значення дослідження полягає в адаптації досвіду зарубіжних практик в умови діяльності дошкільних навчальних закладів України. Подальших наукових розвідок заслуговує питання розробки технології організації соціально-педагогічної підтримки батьків в умовах дошкільного навчального закладу.
ПІДГОТОВКА ВЧИТЕЛІВ ІНОЗЕМНИХ МОВ ДО РОБОТИ В НОВІЙ УКРАЇНСЬКІЙ ІНКЛЮЗИВНІЙ ШКОЛІ
Authors: Шапочка Катерина
Published: March 2023

Стаття присвячена питанню кадрової підготовки в умовах Нової української інклюзивної школи, зокрема підготовці вчителів іноземних мов до роботи у новому освітньому середовищі, озброєними новими теоретичними знаннями і готовими ефективно використовувати їх на практиці в команді з іншими педагогами, фахівцями, батьками, учнями. Наголошується на забезпеченні рівних можливостей для здобуття освіти й подальшої інтеграції людей з порушеннями психофізичного розвитку. Підготовка вчителів іноземних мов до роботи в інклюзивній школі в Україні вимагає зміни навчальних і робочих програм, зокрема, відведення певної кількості годин (кредитів) в межах дисциплін (педагогіка, психологія, методика викладання іноземних мов), що вивчаються згідно навчальних планів, на вивчення психофізіологічних, психолого-педагогічних особливостей дітей з особливими потребами. Крім того, необхідною умовою професійного розвитку вчителів іноземних мов є участь у тренінгах та заходах, до проведення яких необхідно залучати фахівців спеціальних навчальних закладів, інклюзивних шкіл, науковців та інших спеціалістів. В статті наголошується, що вчителі іноземних мов повинні стати частиною команди, оскільки тільки спільна робота команди фахівців дасть можливість подолати перешкоди та отримати позитивний результат. Ефективне інклюзивне навчання можливе лише за умови підготовки та перепідготовки педагогічних кадрів.
ЕВОЛЮЦІЙНІ СТРАТЕГІЇ ОСВІТИ ДІТЕЙ З ОСОБЛИВИМ ПОТРЕБАМИ: ДОСВІД КАНАДИ
Authors: Наконечна Лариса
Published: March 2023

У статті представлено аналіз впровадження інклюзивного навчання в Канаді. Канада має достатньо тривалу історію інклюзивного навчання. Здійснення аналізу дасть змогу виявити можливості застосування найбільш ефективних стратегій реалізації інклюзії в системі освіти України. Визначення загальних компонентів та специфічних особливостей реалізації інклюзивного навчання на основі ідейних трактувань дасть змогу визначити загальне характерологічне підґрунтя інклюзивної форми навчання та ефективно використовувати позитивний досвід провідних країн світу в українських реаліях.
Construction of rational interpolations using Mamquist-Takenaka systems
Authors: Nagy-csıha Zsuzsanna , Pap Margıt , Weisz Ferenc
Published: March 2023

Rational functions have deep system-theoretic significance. They represent the natural way of modeling linear dynamical systems in the frequency (Laplace) domain. Using rational functions, the goal of this paper to compute models that match (interpolate) given data sets of measurements. In this paper, the authors show that using special rational orthonormal systems, the Malmquist-Takenaka systems, it is possible to write the rational interpolant $r_{(n, m)}$, for $n=N-1, m=N$ using only $N$ sampling nodes (instead of $2N$ nodes) if the interpolating nodes are in the complex unit circle or on the upper half-plane. Moreover, the authors prove convergence results related to the rational interpolant. They give an efficient algorithm for the determination of the rational interpolant.
Determination the influence of the rock mass density on the productivity of wheel loaders at the iron ore pit mining
Authors: Sobko B , Lozhnikov O , Voronyi M
Published: March 2023

Aim. To establish the dependence of the front loader performance on the bulk density of the rock mass at the mining of iron ore deposit. Research methodology. At the developing the methodology, analytical and computational research methods were used to determine the time of working off rock mass of different density by a front loader. Appropriate calculation methods are relevant for determining the required amount of technical equipment and are acceptable for modern mining. Research results. A method has been developed for establishing the duration of the working cycle and the productivity of a front-end loader when mining different types of rock mass at an iron ore pit mining. Efficient parameters of rock extraction have been established, depending on changes in rock density. In the course of the study, the relationship between the density of the rock mass and the coefficient of filling and the coefficient of loosening of the rock was established. The influence of these coefficients directly on the performance of front loaders is determined.The indicators of these coefficients depend on the physical and mechanical properties of soft and rocky rocks and can change the performance of front loaders up to 5 times. Scientific novelty. It has been established that the duration of the working cycle is based on the time of digging (depending on the specific gravity of the rock mass), the time of maneuvering and the time of unloading, which are determined by the technical characteristics of mining machines. The influence of the bulk density of the rock mass on the duration of the working cycle and the performance of the front loader is determined. The required number of front-end loaders of different capacities was calculated as excavation and loading equipment in the conditions of the iron ore deposit mining. Practical value. The developed method for calculating the performance of a front-end loader depending on the density of the rock mass makes it possible to determine the effective number of loaders in the conditions of mining iron ore pits, which is confirmed by the example of the Eristovsky MPP.
Self-adjusting filling control system forself-grinding drum mills
Authors: Novitskyi I , Sliesariev V , Shevchenko Y
Published: March 2023

Purpose of work isan improvement of the controlling efficiency for the processes of self-grinding ores in drum mills by using adaptive settings for the perimeters of the control part of the system. Methodology. For the self-grinding process, the degree of filling of the mill drum is a critical technological variable, i.e. this parameter not only has a direct impact on the efficiency of the grinding unit in terms of the newly formed finished product, but also determines the trouble-free operation of the mill.It is known from the referenced literature that during thedecay time of the autocorrelation function for the processes of original ore’s main characteristics change is on the order of several hours or more. At the same time, the inertia of the crushed aggregate is measured in tens of minutes. Under such conditions, one should assume that quasi-stationarity and the rational use of the control system for a wide scope of self-grinding take place. Research results. Using the method of auxiliary operators, the law for setting the parameters of the main circuit of the self-adjusting system was generated, and the block diagrams of the adaptive control system for filling ore self-grinding mills were determined. The transient processes in the control system are calculated, which proves the expediency and effectiveness of the proposed approach. Scientific novelty. A new approach is proposed using an adaptive control system to regulate the degree of filling of autogenous ores mills, based on the use of the method of auxiliary operators. Practical significance. While calculating the tuning processes in the control system for the filling degree of the mill, it was found that even with a simultaneous abrupt change in the object’s parameters K0,T1,T2to the maximum value, the adaptive system completes tuning the parameters of the controllerC1, C2, C3 for a time of about 230 ÷ 270 minutes, which indicates the practical feasibility and effectiveness of this approach to control the filling level of ore self-grinding mills.
The concept of the "National Informatization Program" (1998): structural and content analysis
Authors: Sereda Khrystyna
Published: March 2023

The abstracd describes the structural and content analysis of the concept of the "National Informatization Program" (1998).
Effects of commercial entomopathogen-based formulations on Neoseiulus sp. in pine trees
Authors: Mendes Joiran Souza , Paes Jhersyka da Silva , Carvalho Samara Arêas , Sant’Ana Letícia Caroline da Silva , Freitas Damaris Rosa de , Picanço Marcelo Coutinho
Published: March 2023

Biological control is a growing branch in Brazil, and with it comes the need to obtain efficient enemies in the control of pests. The use of entomopathogens has expanded and with it comes the need to investigate their selectivity to non-target organisms. The present work was conducted in a pinecone (Annona squamosa L.) orchard with the objective of evaluating in which locations of the plant (lower, middle or upper third) and the effects of the entomopathogens: Beauveria bassiana, Metharhizium anisoplie and Bacillus thuringiensis on the predatory mite. Sixteen weekly applications were made between March and August 2017 with a constant pressure knapsack sprayer, nozzle type JA-2 with the jet directed at the entire plant. The treatments consisted of the use of three entomopathogenic biological products: Dipel, Beuaveria bassiana JCO and Metarhizium anisopliae JCO applied alone and in combination. Eight treatments were performed, as follows: T1-Spraying with M. anisopliae + phfos (Quimifol) + adhesive spreader (Agral), T2-Spraying with B. bassiana + phfos (Quimifol) + adhesive spreader (Agral), T3-Spraying with B. thruringiensis + phfos (Quimifol) + adhesive spreader (Agral), T4-Spraying with M. anisopliae + B. basisiana + phfos (Quimifol) + adhesive spreader (Agral), T5- Spraying with M. anisopliae + B. thruringiensis + phfos (Quimifol) + adhesive spreader (Agral), T6- Spraying with B. bassiana + B. thruringiensis + phfos (Quimifol) + adhesive spreader (Agral); T7- Spraying with M. anisopliae + B. bassiana + B. thruringiensis + phfos (Quimifol) + adhesive spreader (Agral) e T8-Testify, spraying with phfos (Quimifol) + adhesive spreader (Agral). The results indicate a preference of the Neoseiulus sp. mite for the middle third of the plant canopy. The results obtained indicated that the entomopathogens influenced the population of the Neoseiulus sp. mite until the sixth week after treatment, where the combination of Metarhizium anisopliae + Beauveria bassiana + Bacillus thuringiensis was the one that most negatively affected the population of the predatory mite Neoseiulus sp.
Home Self-collection to test for Human Papillomavirus and Chlamydia trachomatis infection in riverside women in Amazonas
Authors: Batista Sávio José Silva , Gomes Ananda Maria Pinto , Oliveira Theresa Kalliny Lima de , Lobato Tatiana Caroline Lima , Dantas Jaynne de Souza , Oliveira Fabyanne Guimarães de , Mendes Cleiton de Souza , Azevedo Maria Joana Nunes de , Reis Renato dos Santos , Rocha Danielle Albuquerque Pires
Published: March 2023

Women living in rural areas of Amazonas - the riverine - have difficulty accessing adequate health care, aggravating their vulnerability in the face of various pathological processes, such as cervical cancer and sexually transmitted infections. Strategies that expand coverage of screening and early diagnosis are welcome. To evaluate the prevalence of Human Papillomavirus (HPV) and Chlamydia trachomatis (CT) in riverside women from Coari City, Amazonas, in samples obtained by self-collection and to verify the acceptance of this method among the participants. Fifty eight riverside communities were visited, with a “house-to-house” approach. The samples were obtained with a COARI® brush (Kolplast®) and the diagnosis of pathogens was made by Polymerase Chain Reaction. Four hundred and nineteen sexually active women aged between 18 and 70 years old (34.4 ± 12.1) participated in the study. The prevalence of CT in this population sample was 1.1% and that of HPV was 15.7%. We observed a low prevalence of CT and a high prevalence of HPV among participating women, in addition to a good acceptance of self-collection among them.
Benefícios das Limas rotatórias no tratamento endodôntico: uma revisão da literatura
Authors: Dias Khezia Vitória Oeiras , Negreiros Rayssa Ribeiro de , Vasconcelos Alessandra Silva de , Carvalho Giselle Moreira de , Almeida Matheus Fontes de , Lira Maria Eduarda Soares Fernandes , Mizoguchi Cristiane Mitie Imada , Barroso Júnior Severino de Souza , Santos Cicera Andreza Alves dos , Zitlow Hernandes Bull
Published: March 2023

Com os avanços tecnológicos, cada vez mais pesquisas têm sido feitas para oferecer inovações, dispositivos e materiais biocompatíveis para a área da odontologia. A literatura confirma os benefícios do uso dessas tecnológicas em consultórios odontológicos. Os clínicos que atuam na área da endodontia devem estar cientes de todas as características e capacidade dos instrumentos que são possíveis de se usar ao realizar um tratamento de canal radicular. Dessa forma, o objetivo deste estudo é revisar e avaliar a literatura a eficácia e os benefícios das Limas rotatórias no tratamento endodôntico. Para a construção deste artigo foi realizado um levantamento bibliográfico nas bases de dados SciVerse Scopus, Scientific Eletronic Library Online (Scielo), U.S. National Library of Medicine (PUBMED) e ScienceDirect, com auxílio do gerenciador de referências Mendeley. Os artigos foram contemplados entre os anos de 2000 a 2023. Os instrumentos rotatórios diminuem o tempo de trabalho do profissional, reduzem as possibilidades de contaminação cruzada pelo uso repetitivo do instrumento, pois são descartados após cada procedimento. Os sistemas apresentam excelentes resultados e quanto utilizado seguindo as recomendações e indicações, previnem iatrogenias durante o preparo. Por fim, mais estudos precisam ser feitos usando tamanho de amostra alto para avaliar a eficiência comparativa da instrumentação rotativa e manual. Uma conclusão definitiva não pode ser tirada da literatura disponível, no entanto, a escolha do protocolo de tratamento pode ser feita com base nos requisitos clínicos.
Alterações da ATM e sua relação com o surgimento de deformidades dentofaciais: revisão de literatura
Authors: Alencar Renan Dias de , Pereira Raíres do Nascimento , Oliveira Luís Gustavo Soares Lula de , Castro Juliana Campos , Nascimento Wendy Saureana Maior de Oliveira , Santos Bruno Nascimento , Agostinho Cícero Newton Lemos Felício
Published: March 2023

Alterações na articulação temporomandibular possuem variadas etiologias, podendo repercutir de forma negativa tanto na funcionalidade quanto na estética facial do indivíduo. O côndilo mandibular, um dos principais componentes da ATM, é um local de crescimento adaptativo que influencia na conformidade final da face, por isso, é conspícuo a relação entre as patologias da ATM e as deformidades dentofaciais. Portanto, o objetivo desse estudo é explanar alterações da articulação temporomandibular, sobretudo em região de côndilo, e relacioná-las com o surgimento de deformidades dentofaciais. O presente trabalho foi realizado por meio de uma revisão de literatura narrativa com base em artigos indexados no SciELO, Google Acadêmico, PubMed e Biblioteca Virtual de Saúde. Foram incluídos artigos científicos, dissertação de mestrado e livros, publicados no período de 2010 a 2022, de forma completa, escritos em português, inglês e espanhol, e excluídos trabalhos publicados antes de 2010 e que não tinham relação com o tema abordado. Assim, foram selecionadas 31 obras para a confecção deste trabalho, onde as alterações da ATM que possuem relação com o surgimento de deformidades dentofaciais abordadas no presente trabalho, são: hiperplasia, hipoplasia e aplasia condilar, osteoma, osteocondroma e anquilose da articulação temporomandibular. Portanto foi possível perceber que o desenvolvimento fisiológico da ATM, especialmente o da estrutura condilar, sem qualquer alteração que possa prejudica-la, como traumas e infecções, é essencial para evitar a conversão em deformidades dentofaciais.
Silimarina e distúrbios hepáticos: uma revisão da literatura
Authors: Ramalho Alyne Cerqueira , Figueira Hávilla Clycia Oliveira Siqueira , Franco Jessyka Viana Valadares , Gontijo Érica Eugênio Lourenço , Azeredo João Paulo Silva , Leão Natallia Moreira Lopes , Costa Thalita Melo França
Published: March 2023

Os distúrbios hepáticos são doenças ligadas ao fígado. Tendo em vista a gravidade destes distúrbios e as dificuldades em se estabelecer um tratamento para eles, decidiu-se propor um novo modelo de tratamento, utilizando a silimarina, uma planta que vem sendo utilizada desde os tempos antigos na cura de diversas doenças. Diante disso, o objetivo dessa pesquisa foi discutir o real impacto que a silimarina possui nos distúrbios hepáticos. Para isso, esse estudo teve como base uma revisão bibliográfica descritiva, ao qual foi fundamentada em trabalhos científicos já publicados entre os anos de 2018 a 2022 em língua portuguesa e que tratavam especificamente sobre a temática proposta. A coleta de dados se deu em base de banco de dados, tais como Google Acadêmico, Scielo, PubMed e Lilacs, do qual resultaram 21 trabalhos científicos analisados e divulgados no decorrer desse estudo. Nos resultados encontrados, ficou claro observar que a Silimarina contribui para melhorar o intestino e o sistema digestivo em geral; modulando o equilíbrio da microbiota (pelo estímulo a proliferação de lactobacillus e bifidobactérias, o que teria importante efeito papel imunomodulador). Ainda tem ação anti-hepatotóxica, isso significa, ter ativos de proteção ao fígado e por fim, ajuda no tratamento de doenças hepáticas.
Perfil sociodemográfico e clínico de usuários com paralisia cerebral atendidos em unidades de atenção primária à saúde no município de Milagres no Ceará
Authors: Marques Daniela Ferreira , Almeida Angélica Maria de Oliveira , Brandão Monísya Oliveira Ferreira , Tabosa Tereza Águida Costa do Nascimento
Published: March 2023

A encefalopatia crônica não progressiva, usualmente, chamada de paralisia cerebral, é ocasionada por uma lesão permanente no encéfalo em desenvolvimento. Ela é considerada a causa mais comum de deficiência motora na infância. Sua origem é heterogênea e complexa, podendo ser ocasionada por fatores de risco pré-natais, perinatais ou pós-natais. Diante desse contexto, juntamente com as vivências da pesquisadora no processo de territorialização na cidade de Milagres – Ceará, surgiu a seguinte questão: como se configura o perfil dos usuários com paralisia cerebral atendidos em unidades de atenção primária à saúde neste município? O estudo objetiva analisar o perfil sociodemográfico e clínico de usuários com paralisia cerebral atendidos em unidades de atenção primária à saúde no município de Milagres, no Ceará. Trata-se de um estudo transversal, descritivo, de abordagem quantitativa. A população do estudo foi composta por onze usuários e a amostra resultou em seis usuários. A análise dos dados foi realizada por meio SPSS 20.0. Foi evidenciado que a maioria dos entrevistados possuía classificação no CID 10- G80 e predominância do tônus tipo espástico. Encontramos nos entrevistados distúrbios musculoesqueléticos, distúrbios no comportamento, distúrbios respiratórios e epilepsia. Metade dos usuários frequentavam algum serviço de reabilitação e a grande maioria recebia, unicamente, o acompanhamento fisioterapêutico. Sugere-se que políticas públicas em saúde curativas e preventivas sejam intensificadas e direcionadas às particularidades dos usuários com paralisia cerebral e seus familiares, assim como, sejam realizadas novas pesquisas que fundamentem essas políticas públicas em saúde, de forma a otimizar o acesso desses usuários aos serviços terapêuticos especializados.
Historiografia cartográfica: um panorama descritivo sobre a produção dos mapas em distintas sociedades
Authors: Teódulo José Mácio Ramalho , Cirino Carlos da Silva
Published: March 2023

esse ensaio objetivou apresentar um breve panorama descritivo sobre a relevância da produção cartográfica através da história. Buscou refletir, de forma não exaustiva, sua contemporaneidade e importância, traduzida através de mapas emblemáticos: suas principais características, seu processo de comunicação e informação, seu estágio evolutivo e suas famílias. Estudar e compreender seu papel, ao longo de distintas épocas, torna-se relevante por elencar questões geopolíticas, socioculturais e formativas. Historiografar se justifica em ressaltar elementos imperativos que tangenciaram rumos territoriais e definiram rotas para a humanidade. Esses elementos teóricos/técnicos, que determinaram parâmetros e direções, lançaram as bases para ferramentas cartográficas do tempo presente. A metodologia foi pautada em um estudo exploratório de abordagem qualitativa, fundamentada em autores da área, tais como: Brotton, Harley, Harley e Woodward, Raisz, entre outros. A escrita foi organizada de forma estritamente não linear, disposta dentro de uma sequência lógica de eventos. Como consideração final pode-se constatar que desde que o sujeito homem se viu como ser pensante, em algum período da humanidade, decidiu esboçar seu território geográfico. Desse ponto de partida estruturou, a partir da representação de seu espaço, nova forma de expressar, dominar, controlar e expandir seu ambiente societário.
Impacto da pandemia do COVID-19 no cuidado a crianças com autismo
Authors: Lima Ana Karoline de Almeida , Silva Kely Vanessa Leite Gomes da , Lima Victoria Maria de Almeida , Lima Maria Gisleide Penha de , Araújo Alécia Hercídia , Teles Mariana Bárbara Lira , Borges Andreza de Santana , Leonel Ana Camila Gonçalves , Lima Lucas Alves , Sidrim Antonio Coelho
Published: March 2023

O estudo teve como objetivo verificar quais foram os impactos a saúde mental mais acometidos a cuidadores de crianças com autismo e as dificuldades para desenvolver o cuidado necessário. Trata-se de uma pesquisa descritivo exploratória com abordagem qualitativa realizada no período de maio a dezembro de 2021. A coleta de dados ocorreu por meio da construção de um questionário eletrônico, sendo desenvolvido pelo método “bola de neve” o qual permite a analisar respostas qualitativas, assim, após um contato prévio com o grupo de participantes foi divulgado através de e-mails e redes sociais (WhatsApp, Facebook, Instagram), com intuito de captar o maior número de cuidadores de crianças com autismo. Obteve-se a colaboração de 31 participantes que puderam responder as perguntas. Os resultados revelaram que a grande maioria dos cuidadores eram do sexo feminino e que mais da metade das crianças com diagnóstico de Transtorno do Espectro Autista era do sexo masculino. Foi evidenciado que muitos dos cuidadores tinham uma comunhão estável, no entanto, verificou-se que havia algumas dificuldades no compartilhamento de obrigações. Constatou-se que parte do grupo da pesquisa possuíam obstáculos quanto a proporcionar uma assistência qualificada e um suporte para as necessidades das crianças, na maioria das vezes pela ausência ou pouco apoio e também acerca da questão socioeconômica. Nesse sentido, percebeu-se que se teve uma vasta sobrecarga para os cuidadores responsáveis bem como um comprometimento da saúde mental dos mesmos.
Chemo-enzymatic synthesis and analysis of isomeric glycans
Authors:   , Vos Gaël Martijn
Published: March 2023

Glycans, also known as carbohydrates, are an essential component of all living organisms and are, among other things, present on proteins and lipids in the cellular membrane. Glycan structure is not encoded in the genome, oppose to other biopolymers such as RNA and proteins, but is regulated by around 200 glycosyltransferase enzymes. As a result of substrate competition, glycans are generated that vary in composition, linkage positions and configurations. The large heterogeineity and diversity in glycan structure complicates the synthesis and characterization of glycans.
The research described in this dissertation covers the synthesis of well-defined glycans and applies synthetic glycans in the development of analytical methodology for the detailed structural characterization of naturally occuring glycans. Chemically modified glycans are synthesized by employing glycosyltransferase enzymes. These modifications are manipulated to (de)activate certain positions on a glycan and thereby direct glycosyltransferase activity. Traceless removal of these modifications allows the synthesis of complex natural glycans with controlled architecture. These glycans are used to study differences in biological activity between isomeric glycans. Synthetic glycopeptides with various functionalities are used as model substrates to develop a method to release glycans from glycopeptides without damaging the glycan structure itself. This methodology conserves labile glycan modifications that are often lost in glycan analysis. Furthermore, synthetic complex glycans are applied as reference compounds for the development of analytical methodology that can structurally elucidate challenging glycan epitopes.
NAFKAH IN FIQIH AND INDONESIAN LAW PERSPECTIVE ;
Authors: Masruri Ahmad Halimi
Published: March 2023

This article is the result of a qualitative field research. This research is a legal sociology research. This article discusses the neglect of livelihoods that occurred in Gedang Hamlet, Tambakrejo Village. Researcher analyzes the research data with fiqh theory and the Undang-undang Perkawinan No.1 1974. The findings of this study are that the neglect of livelihood that occurs in Gedang Hamlet, Tambakrejo Village is included in the category of violation of the income obligation, it can even be included as domestic violence. There are two things to be argued. Ms. LM's husband has not given her a living for 6 months, the second is that Mrs. LM's husband often comes home at night, sometimes even for several days he does not come home. fiqh clearly mentions the categories of earning a living, although with many variations. All fiqh differences of opinion about the limits of living were violated by LM's mother's husband. Law No. 23 of 2004 was also violated in terms of fulfilling the husband's support for his wife.

Keyword: living limits, fiqh, the rule of law

 

Abstrak

 Artikel ini adalah hasil penelitian kualitatif lapangan. Penelitian ini merupakan penelitian sosiologi hukum. Artikel ini mendiskusikan penelantaran nafkah yang terjadi di Dusun Gedang Desa Tambakrejo. Peneliti menganalisis data penelitian dengan teori fiqih dan undang-undang Perkawinan Nomor 1 Tahun 1974. Temuan penelitian ini adalah bahwa penelantaran nafkah yang terjadi di Dusun Gedang Desa Tambakrejo termasuk kategori pelanggaran kewajiban nafkah, bahkan dapat dimasukkan tindak kekerasan dalam rumah tangga. Ada dua hal yang menjadi argument. Suami Ibu LM ini sudah selama 6 Bulan tidak memberi nafkah, yang kedua adalah bahwa suami Ibu LM sering pulang malam, bahkan terkadang selama beberapa hari tidak pulang kerumah. fikih menyebutkan secara jelas kategori pemenuhan nafkah walaupun dengan banyak variasi perbedaan. Kesemua perbedaan pendapat fiqih tentang batasan nafkah dilanggar oleh suami ibu LM. Undang-undang No 23 Tahun 2004 juga dilanggar dalam hal pememnuhan nafkah suami terhadap istri.

 

Kata Kunci: batas nafkah, fikih, aturan undang-undang
Probe-integrated electrochemical immunosensor based on electrostatic nanocage array for reagentless and sensitive detection of tumor biomarker
Authors: Chen Dong , Luo Xuan , Xi Fengna
Published: March 2023

Sensitive detection of tumor biomarkers is crucial for early diagnosis and prognosis evaluation of cancer. Owing to no need of labelled antibody, formation of sandwich immunocomplexes and additional solution-based probe, probe-integrated electrochemical immunosensor for reagentless detection of tumor biomarkers is highly desirable. In this work, sensitive and reagentless detection of a tumor biomarker is realized based on fabrication of a probe-integrated immunosensor by confining redox probe in electrostatic nanocage array modified electrode. Indium tin oxide (ITO) electrode is employed as the supporting electrode because it is cheap and easily available. The silica nanochannel array consisted of two layers with opposite charges or different pore diameters was designated as bipolar films (bp-SNA). In this work, Electrostatic nanocage array is equipped on ITO electrode by growth of bp-SNA with two layered nanochannel array having different charge properties including a negatively charged silica nanochannel array (n-SNA) and a positively charged amino-modified SNA (p-SNA). Each SNA can be easily grown with 15 s using electrochemical assisted self-assembly method (EASA). Methylene blue (MB) is applied as the model electrochemical probe with positive charge to be confined in electrostatic nanocage array with stirring. The combination of the electrostatic attraction from n-SNA and the electrostatic repulsion from p-SNA endows MB with highly stable electrochemical signal during continuous scanning. When the amino groups of p-SNA are modified using the bifunctional glutaraldehyde (GA) to introduce aldehydes, the recognitive antibody (Ab) of the most commonly used tumor biomarker, carcinoembryonic antigen (CEA), can be covalently immobilized. After the non-specific sites are blocked, the immunosensor is successfully fabricated. As the formation of antigen-antibody complex decreases electrochemical signal, the immunosensor can achieve reagentless detection of CEA ranged from 10 pg/mL to 100 ng/mL with a low limit of detection (LOD, 4 pg/mL). Determination of CEA in human serum samples is realized with high accuracy.
Understanding of the structural chemistry in the uranium oxo-tellurium system under HT/HP conditions
Authors: Hao Yucheng , Langer Eike M. , Xiao Bin , Kegler Philip , Cao Xin , Hu Kunhong , Eichel Rüdiger-A. , Wang Shuao , Alekseev Evgeny V.
Published: March 2023

The study of phase formation in the U-Te-O systems with mono and divalent cations under high-temperature high-pressure (HT/HP) conditions has resulted in four new inorganic compounds: K2 [(UO2) (Te2O7)], Mg [(UO2) (TeO3)2], Sr [(UO2) (TeO3)2] and Sr [(UO2) (TeO5)]. Tellurium occurs as TeIV, TeV, and TeVI in these phases which demonstrate the high chemical flexibility of the system. Uranium VI) adopts a variety of coordinations, namely, UO6 in K2 [(UO2) (Te2O7), UO7 in Mg [(UO2) (TeO3)2] and Sr [(UO2) (TeO3)2], and UO8 in Sr [(UO2) (TeO5)]. The structure of K2 [(UO2) (Te2O7)] is featured with one dimensional (1D) [Te2O7]4- chains along the c-axis. The Te2O7 chains are further linked by UO6 polyhedra, forming the 3D [(UO2) (Te2O7)]2- anionic frameworks. In Mg [(UO2) (TeO3)2], TeO4 disphenoids share common corners with each other resulting in infinite 1D chains of [(TeO3)2]4- propagating along the a-axis. These chains link the uranyl bipyramids by edge sharing along two edges of the disphenoids, resulting in the 2D layered structure of [(UO2) (Te2O6)]2-. The structure of Sr [(UO2) (TeO3)2] is based on 1D chains of [(UO2) (TeO3)2]∞2− propagating into the c-axis. These chains are formed by edge-sharing uranyl bipyramids which are additionally fused together by two TeO4 disphenoids, which also share two edges. The 3D framework structure of Sr [(UO2) (TeO5)] is composed of 1D [TeO5]4− chains sharing edges with UO7 bipyramids. Three tunnels based on 6-Membered rings (MRs) are propagating along [001] [010] and [100] directions. The HT/HP synthetic conditions for the preparation of single crystalline samples and their structural aspects are discussed in this work.