bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis and properties of methyl hexahydrophthalic anhydride‐cured fluorinated epoxy resin 2,2‐bisphenol hexafluoropropane diglycidyl ether
Authors: Yin Miao , Yang Li , Li Xiu‐yun , Ma Han‐bing
Published: June 2013

The fluorinated epoxy resin, 2,2‐bisphenol hexafluoropropane diglycidyl ether (DGEBHF) was synthesized through a two‐step procedure, and the chemical structure was confirmed by 1H nuclear magnetic resonance (NMR), 13C NMR, and Fourier transform infrared (FTIR) spectra. Moreover, DGEBHF was thermally cured with methyl hexahydrophthalic anhydride (MHHPA). The results clearly indicated that the cured DGEBHF/MHHPA exhibited higher glass transition temperature (Tg 147°C) and thermal decomposition temperature at 5% weight loss (T5 372°C) than those (Tg 131.2°C; T5 362°C) of diglycidyl ether of bisphenol A (DGEBA)/MHHPA. In addition, the incorporation of bis‐trifluoromethyl groups led to enhanced dielectric properties with lower dielectric constant (Dk 2.93) of DGEBHF/MHHPA compared with cured DGEBA resins (Dk 3.25). The cured fluorinated epoxy resin also gave lower water absorption measured in two methods relative to its nonfluorinated counterparts. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 130: 2801–2808, 2013
Estimating retail demand with Poisson mixtures and out‐of‐sample likelihood
Authors: Chuang Howard Hao‐Chun , Oliva Rogelio
Published: June 2013

Estimation of retail demand is critical to decisions about procuring, shipping, and shelving. The idea of Poisson demand process is central to retail inventory management and numerous studies suggest that negative binomial (NB) distribution characterize retail demand well. In this study, we reassess the adequacy of estimating retail demand with the NB distribution. We propose two Poisson mixtures—the Poisson–Tweedie family (PTF) and the Conway–Maxwell–Poisson distribution—as generic alternatives to the NB distribution. On the basis of the principle of likelihood and information theory, we adopt out‐of‐sample likelihood as a metric for model selection. We test the procedure on consumer demand for 580 stock‐keeping unit store sales datasets. Overall the PTF and the Conway–Maxwell–Poisson distribution outperform the NB distribution for 70% of the tested samples. As a general case of the NB model, the PTF has particularly strong performance for datasets with relatively small means and high dispersion. Our finding carries useful implications for researchers and practitioners who seek for flexible alternatives to the oft‐used NB distribution in characterizing retail demand. Copyright © 2013 John Wiley & Sons, Ltd.
Alterung von Bewehrungsgittern aus Polyester
Authors: Müller Werner
Published: June 2013

Durch die hydrolytische Alterung ändert sich die Zugfestigkeit eines Polyester‐Bewehrungsgitters im Laufe der Zeit. Nach den Empfehlungen für den Entwurf und die Berechnung von Erdkörpern mit Bewehrung aus Geokunststoffen (EBGEO) der DGGT wird dieser Effekt durch einen Abminderungsfaktor bei der Bemessung berücksichtigt. Es ist zwar im Prinzip festgelegt, wie man bei der Bestimmung eines solchen Faktors für eine chemisch bedingte Materialveränderung vorgehen soll (ISO/TR 20432), es bleiben jedoch große Freiheiten bei der Umsetzung. Die Fragen, die sich daraus bei Bewehrungsgittern aus Polyester ergeben, werden diskutiert. Es werden Bausteine eines einheitlichen Verfahrens vorgeschlagen, das sich nicht nur auf den Festigkeitsverlust, sondern auch auf die molekulare Veränderung konzentriert.

Aging of PET geodrids

Due to hydrolytic aging of the polyester material the tensile strength of PET‐geogrids will change with time. According to the design recommendations (EBGEO) of the German Geotechnical Society DGGT this effect has to be taken into account by a factor of reduction. In principle the determination of the factor for chemical degradation is described in ISO/TR 20432. However, there is a considerable discretionary leeway in realizing the procedure for a special type of product. The questions, which occur from this for PET‐geogrids, will be discussed in detail. Against this background building stones of a well‐defined procedure are suggested, which considers not only mechanical degradation but also degradation in molecular weight.
Ganzheitliche Planung eines Hochwasserrückhaltebeckens
Authors: Küenzlen Jürgen H. R. , Lind Dieter
Published: June 2013

Die vorgestellte private Planungsvariante eines Hochwasserrückhaltebeckens zeigt, dass auch rein technische Ingenieurbauwerke unter ganzheitlicher Betrachtung ein Gewinn für die gesamte Umgebung – und nicht alleine für den Hochwasserschutz – sein können. Bei der Planung und Ausführung derartiger Bauwerke darf sich der planende Ingenieur nicht von seinem Technikbauwerk einnehmen lassen. Es ist viel mehr notwendig, das Projekt in seiner ganzen Dimension und unter Einbeziehung aller Belange zu betrachten und zu lösen. Dabei ist es unerlässlich, frühzeitig alle Beteiligten einzubeziehen und sich mit deren Vorstellungen auseinanderzusetzen, wobei auch für einen Ingenieur ein gewisses “Fingerspitzengefühl” im Umgang mit von der Baumaßnahme besonders betroffenen Anwohnern unverzichtbar ist. Ein reines “sich darauf verlassen”, dass bei öffentlichen Bauprojekten die Projektlösung alleine durch “Verwaltungsmacht” bzw. gerichtliche Auseinandersetzungen herbeigeführt werden kann, ist im 21. Jahrhundert auf keinen Fall mehr zeitgemäß. Auch das bequeme Zurückziehen auf das einfache und fast immer zutreffende Argument “Kosteneinsparung” kann nicht allein gelten, da bei Bauwerken mit Veränderung und Verlegung ganzer Flussläufe über zeitliche Dimensionen von 100 Jahren und mehr nachgedacht werden muss.

Holistic planning of a flood control reservoir

The presented private planning option of a flood control reservoir shows that even solely technical engineering structures like flood control reservoirs can prove to be beneficial for the whole environment and not only with regard to flood prevention when looked at in their entirety. The planning engineer, however, must not only concentrate on the technical structure when it comes to planning and execution of structures like that. In fact, it is necessary to regard and solve this project in its whole dimension, involving all issues. It is essential to include all parties involved and to deal with their conceptions at an early stage. This makes it indispensable for the engineer to have a certain intuition when it comes to dealing with residents who are strongly affected by the building project. In the 21st century it is not contemporary anymore to just “rely” on the notion that the solution for a project can simply be brought about by “administrative power” respectively judicial dispute. Moreover, the convenient retraction to the simple and almost always applicable argument of “cost savings” cannot solely apply because structures like this kind of retention reservoirs including the transformation and relocation of complete river courses require the need to take dimensions of 100 years and more into account.
Valproate prescriptions for nonepilepsy disorders in reproductive‐age women
Authors: Adedinsewo Demilade A. , Thurman David J. , Luo Yao‐Hua , Williamson Rebecca S. , Odewole Oluwaseun A. , Oakley Godfrey P.
Published: June 2013

BACKGROUND

Scientific evidence has consistently shown taking valproate during pregnancy increases risks of congenital malformations and cognitive impairment. As such, elimination of its use would be an important step in birth defects prevention. There are guidelines discouraging its use among women with epilepsy, but none exists for women without epilepsy, nor is the prevalence of valproate for nonepilepsy indications known.

METHODS

Using de‐identified data from the National Hospital and Ambulatory Medical Care Surveys (1996–2007), we examined individual prescriptions for reproductive‐age adolescent girls and adult women ages 15 to 44 years in the United States, and estimated the number of antiepileptic drug and valproate prescriptions in the aggregate. We classified our study population using International Classification of Diseases, Ninth Revision, Clinical Modification diagnosis codes, as women with epilepsy and women without epilepsy. The prevalence of antiepileptic drug and valproate prescriptions among women without epilepsy was estimated as prescriptions per 1000 patient visits for every 3‐year time interval and the overall study period.

RESULTS

We found 83% of valproate prescriptions were issued to women without epilepsy and 74% of these were for psychiatric diagnoses. The prevalence of antiepileptic drug prescriptions among women without epilepsy tripled during the study period (10.3 [1996–1998] vs. 34.9 [2005–2007] per 1000 patient visits), whereas valproate prescriptions remained relatively stable (3.1 [1996–1998] vs. 3.7 [2005–2007] per 1000 patient visits).

CONCLUSION

Most women of reproductive age who receive a valproate prescription do not have epilepsy. Valproate prescriptions did not decline, despite increasing knowledge of its teratogenicity. Reducing valproate use among women of reproductive age, especially among those who use the drug for psychiatric indications, would prevent birth defects and cognitive deficits. Birth Defects Research (Part A) 97:403–408, 2013. © 2013 Wiley Periodicals, Inc.
Ein Fahrbahnübergangssystem als Fingerkonstruktion mit einer direkten Einleitung der Verankerungskräfte in den Beton
Authors: Braun Joachim , Tusche Jens
Published: June 2013

Die Fingerkonstruktion ist eine seit Jahrzehnten eingesetzte Fahrbahnübergangskonstruktion. Durch die Form der Finger erzeugt dieser Fahrbahnübergang besonders geringe Schallemissionen und zeichnet sich durch einen hervorragenden Überfahrkomfort aus. Eine neuartige Verankerungslösung, welche die Verankerungskraft mithilfe spezieller Verankerungskörper direkt aus dem Finger in die Brückenkonstruktion weiterleitet, wird derzeit für die Regelprüfung entwickelt und hier vorgestellt. Für die Sicherstellung der Wasserdichtigkeit stehen inzwischen dauerhafte Lösungen zur Verfügung.

An expansion joint system as a finger construction with direct transfer of the anchoring forces into the concrete

Finger construction is an expansion joint construction that has been employed for decades. The finger form means that this expansion joint produces particularly low noise emissions and gives it an excellent comfort when passing by vehicles. An innovative anchoring solution, which transfers the anchoring force with the help of special anchoring elements directly from the finger into the bridge construction, is currently in development for standard testing and is presented here. To ensure water‐tightness of the finger joint, durable solutions have been developed in the meantime.
Diazido Mixed‐Amine Platinum(IV) Anticancer Complexes Activatable by Visible‐Light Form Novel DNA Adducts
Authors: Zhao Yao , Woods Julie A. , Farrer Nicola J. , Robinson Kim S. , Pracharova Jitka , Kasparkova Jana , Novakova Olga , Li Huilin , Salassa Luca , Pizarro Ana M. , Clarkson Guy J. , Song Lijiang , Brabec Viktor , Sadler Peter J.
Published: June 2013

Platinum diam(m)ine complexes, such as cisplatin, are successful anticancer drugs, but suffer from problems of resistance and side‐effects. Photoactivatable PtIV prodrugs offer the potential of targeted drug release and new mechanisms of action. We report the synthesis, X‐ray crystallographic and spectroscopic properties of photoactivatable diazido complexes trans,trans,trans‐[Pt(N3)2(OH)2(MA)(Py)] (1; MA=methylamine, Py=pyridine) and trans,trans,trans‐[Pt(N3)2(OH)2(MA)(Tz)] (2; Tz=thiazole), and interpret their photophysical properties by TD‐DFT modelling. The orientation of the azido groups is highly dependent on H bonding and crystal packing, as shown by polymorphs 1 p and 1 q. Complexes 1 and 2 are stable in the dark towards hydrolysis and glutathione reduction, but undergo rapid photoreduction with UVA or blue light with minimal amine photodissociation. They are over an order of magnitude more potent towards HaCaT keratinocytes, A2780 ovarian, and OE19 oesophageal carcinoma cells than cisplatin and show particular potency towards cisplatin‐resistant human ovarian cancer cells (A2780cis). Analysis of binding to calf‐thymus (CT), plasmids, oligonucleotide DNA and individual nucleotides reveals that photoactivated 1 and 2 form both mono‐ and bifunctional DNA lesions, with preference for G and C, similar to transplatin, but with significantly larger unwinding angles and a higher percentage of interstrand cross‐links, with evidence for DNA strand cross‐linking further supported by a comet assay. DNA lesions of 1 and 2 on a 50 bp duplex were not recognised by HMGB1 protein, in contrast to cisplatin‐type lesions. The photo‐induced platination reactions of DNA by 1 and 2 show similarities with the products of the dark reactions of the PtII compounds trans‐[PtCl2(MA)(Py)] (5) and trans‐[PtCl2(MA)(Tz)] (6). Following photoactivation, complex 2 reacted most rapidly with CT DNA, followed by 1, whereas the dark reactions of 5 and 6 with DNA were comparatively slow. Complexes 1 and 2 can therefore give rapid potent photocytotoxicity and novel DNA lesions in cancer cells, with no activity in the absence of irradiation.
Diastereoselective Hydrogen‐Transfer Reactions: An Experimental and DFT Study
Authors: Godin François , Prévost Michel , Gorelsky Serge I. , Mochirian Philippe , Nguyen Maud , Viens Frédérick , Guindon Yvan
Published: June 2013

Radical reductions of halogenated precursors bearing a heterocycle exo (α) to the carbon‐centered radical proceed with enhanced anti‐selectivity, a phenomenon that we termed “exocyclic effect”. New experimental data and DFT calculations at the BHandHLYP/TZVP level demonstrate that the origin of the exocyclic effect is linked to the strain energy required for a radical intermediate to reach its reactive conformation at the transition state (ΔE≠strain). Furthermore, radical reductions of constrained THP systems indicate that high 2,3‐anti inductions are reached only when the radical chain occupies an equatorial orientation. Hydride deliveries to different acyclic substrates and calculations also suggest that the higher anti‐selectivities obtained with borinate intermediates are not related to the formation of a complex mimicking an exocycle. From a broader standpoint, this study reveals important conformational factors for reactions taking place at a center vicinal to a heterocycle or an α‐alkoxy group.
ChemInform Abstract: Structural Complexity Meets Transport and Magnetic Anisotropy in Single Crystalline Ln30Ru4Sn31 (Ln: Gd, Dy).
Authors: Schmitt Devin C. , Haldolaarachchige Neel , Prestigiacomo Joseph , Karki Amar , Young David P. , Stadler Shane , Jin Rongying , Chan Julia Y.
Published: June 2013

Single crystals of the title compounds are grown from the elements (Ln:Ru:Sn = 12:6:11; evacuated silica tube, 1260 °C, 36 h).
ChemInform Abstract: Synthesis and Structure Determination of CaSi1/3B2/3O8/3: A New Calcium Borosilicate.
Authors: Veron Emmanuel , et al. et al.
Published: June 2013

Crystalline CaSi1/3B2/3O8/3 is observed in situ by high‐temperature XRD during heating (first XRD reflections at 740 °C) from a corresponding glassy composition in the CaO—SiO2—B2O3 ternary system prepared by CaCO3, SiO2, and B2O3 mixtures (Pt crucible, 1200—1500 °C, 2 h, quenching).
ChemInform Abstract: Structure and Luminescence Properties of Bi3+ Activated Ca12Al14O32Cl2 Phosphors.
Authors: Yang Zhigang , Zhao Zhengyan , Wen Yan , Wang Yuhua
Published: June 2013

Ca12Al14O32Cl2:xBi3+ (0.005 ≤ x ≤ 0.7) phosphors are synthesized by solid state reaction of CaCO3, Al2O3, SiO2, NH4Cl, and Bi2O3 (air, alumina crucible, 1150 °C, 10 h).
ChemInform Abstract: Spin and Dipole Ordering in Ni2InSbO6 and Ni2ScSbO6 with Corundum‐Related Structure.
Authors: Mathieu R. , et al. et al.
Published: June 2013

The title compounds are prepared by solid state reaction of NiO, Sc2O3 or In2O3, and Sb2O5 (1300 °C, 24 h).
ChemInform Abstract: Polymer‐Assisted Synthesis of LiNi2/3Mn1/3O2 Cathode Material with Enhanced Electrochemical Performance.
Authors: Lu Yang‐Xuan , Jiang Yan , Yang Ze , Han Jian‐Tao , Huang Yun‐Hui , Ma Jun
Published: June 2013

The title cathode material for Li‐ion batteries is synthesized by a polymer‐assisted solid state reaction method starting with the metal acetates, oxalic acid, and polyethylene glycol (PEG) 400 (800 °C, 5 and 10 h).
ChemInform Abstract: Reactions of Hydrated Singly Charged First‐Row Transition‐Metal Ions M+(H2O)n (M: V, Cr, Mn, Fe, Co, Ni, Cu, and Zn) Toward Nitric Oxide in the Gas Phase.
Authors: van der Linde Christian , Hoeckendorf Robert F. , Balaj O. Petru , Beyer Martin K.
Published: June 2013

Reactions of M+(H2O)n (M: V, Cr, Mn, Fe, Co, Ni, Cu, and Zn; n ≤ 40) with NO are investigated by Fourier transform ion cyclotron resonance mass spectrometry.
ChemInform Abstract: Charge Separation Promoted Activation of Molecular Oxygen by Neutral Gold Clusters.
Authors: Woodham Alex P. , Meijer Gerard , Fielicke Andre
Published: June 2013

The interactions of neutral gold clusters Aun (4 ≤ n ≤ 21) with molecular oxygen in the gas phase are investigated by infrared multiple photon dissociation spectroscopy and quantum chemical DFT calculations in order to get more information of the origin of the high catalytic activity of gold nano‐ and sub‐nanoparticles in low‐temperature oxidation reactions.
ChemInform Abstract: closo‐Hydroborates from Liquid Ammonia: Synthesis and Crystal Structures of [Li(NH3)4]2 [B12H12]·2NH3, Rb2[B12H12]·8NH3, Cs2[B12H12]·6NH2 and Rb2[B10H10]·5NH3.
Authors: Kraus Florian , Panda Monalisa , Mueller Thomas , Albert Barbara
Published: June 2013

The title compounds containing 20.04—52.23 wt.% NH3 and 5.94—13.01 wt.% hydrogen are obtained by reacting the distilled alkali metals with (NBu4)2[B12H12] and liq.
ChemInform Abstract: Crystal and Magnetic Structures and Physical Properties of a New Pyroxene NaMnGe2O6 Synthesized under High Pressure.
Authors: Zhou Jianshi , et al. et al.
Published: June 2013

The new title compound is synthesized by reaction of a stoichiometric mixture of Na2CO3, Mn2O3, and GeO2 in a Walker‐type multianvil module (3 GPa, 800 °C, 24 h).
ChemInform Abstract: SrFe0.5Ru0.5O2: Square‐Planar Ru2+ in an Extended Oxide.
Authors: Romero Fabio Denis , Burr Steven J. , McGrady John E. , Gianolio Diego , Cibin Giannantonio , Hayward Michael A.
Published: June 2013

The title compound is prepared by reduction of SrFe0.5Ru0.5O3 with CaH2 at 400 °C for 96 h.
ChemInform Abstract: Synthesis of Ce2Rh3Ge5 Crystals from a Bismuth Flux.
Authors: Vosswinkel Daniel , Poettgen Rainer
Published: June 2013

The title compound is prepared from the elements in a bismuth flux (Ce:Rh:Ge = 2:1:2; evacuated silica ampule, 1320 K, 1 h) and characterized by single crystal XRD.
ChemInform Abstract: Sugar‐Based Monodentate Phosphoramidite Ligands for Cu‐Catalyzed Enantioselective Conjugate Addition to Enones.
Authors: Bauer Tomasz , Majdecki Maciej , Jurczak Janusz
Published: June 2013

Novel monodentate phosphoramidite ligands (I) based on amines derived from α‐D‐xylofuranose are synthesized and applied to the cuprous triflate‐catalyzed conjugate addition to acyclic and cyclic enones.
ChemInform Abstract: Enantio‐ and Regioselective Intermolecular Benzylic and Allylic C—H Bond Amination.
Authors: Nishioka Yota , Uchida Tatsuya , Katsuki Tsutomu
Published: June 2013

The new Ru(CO)—salen complex RUCAL is used as an effective catalyst for asymmetric benzylic and allylic C—H bond amination using 2‐(trimethylsilyl)ethanesulfonyl azide as the nitrene source.
ChemInform Abstract: Solid‐State and Solvent‐Free Synthesis of Azines, Pyrazoles, and Pyridazinones Using Solid Hydrazine.
Authors: Lee Byeongno , Kang Philjun , Lee Kyu Hyung , Cho Jaeheung , Nam Wonwoo , Lee Won Koo , Hur Nam Hwi
Published: June 2013

Solid hydrazinium carboxylate reacts with α, β, or γ‐diketo compounds under neat conditions A) or B).
ChemInform Abstract: Selective Synthesis of Unsymmetrical Ethers from Different Alcohols Catalyzed by Sodium Bisulfite.
Authors: Yu Jun‐Lai , Wang Hui , Zou Kai‐Feng , Zhang Jia‐Rui , Gao Xiang , Zhang Dan‐Wei , Li Zhan‐Ting
Published: June 2013

The reaction is proposed to proceed via intermediary benzylcations.
ChemInform Abstract: Stereocontrolled Routes to 4‐Methoxypentadienoates for Use in Natural Product Synthesis.
Authors: Craven Philip G. E. , Taylor Richard J. K.
Published: June 2013

Methanolysis of epoxides (I) and (VI) is achieved in complementary ways by employing either Pd‐catalyzed or acid‐mediated procedures.
ChemInform Abstract: Pyrrolidine‐Catalyzed Novel Domino Reaction for the Synthesis of Polysubstituted 4‐Oxocyclohexanecarbaldehyde Derivatives.
Authors: Bao Feng‐Zu , Wang Xiao‐Bing , Kong Ling‐Yi
Published: June 2013

The novel reaction of ketones with α,β‐unsaturated aldehydes allows the synthesis of the title compounds via aldol condensation followed by a tandem inter‐Michael — intra‐Michael addition.
ChemInform Abstract: An Easy Access to Fluoroalkanes by Deoxygenative Hydrofluorination of Carbonyl Compounds via Their Tosylhydrazones.
Authors: Yadav Arvind K. , Srivastava Vishnu P. , Yadav Lal Dhar S.
Published: June 2013

An efficient synthesis of monofluoroalkanes (II) by deoxygenative hydrofluorination of carbonyl compounds via their tosylhydrazones surrogates (I) is presented.
ChemInform Abstract: Stereoselective Synthesis of anti‐1,3‐Aminoalcohols via Reductive Opening of 4‐Amidotetrahydropyrans Derived from the Prins/Ritter Sequence.
Authors: Yadav J. S. , Reddy Y. Jayasudhan , Reddy P. Adi Narayana , Reddy B. V. Subba
Published: June 2013

4‐Amidotetrahydropyrans (IV), prepared by a Prins/Ritter reaction sequence, are readily converted into desired N‐acyl‐aminoalcohols (VI) by a Finkelstein reaction of tosylates (IV) followed by reductive opening of the tetrahydropyran ring of resulting iodides (V).
ChemInform Abstract: Reaction of Benzyne with Fluorinated 1,3‐Dicarbonyl Compounds.
Authors: Zahid Muhammad , Ibad Muhammad Farooq , Abilov Zharylkasyn A. , Langer Peter
Published: June 2013

Various fluorinated 1,5‐dicarbonyl compounds (III) are regioselectively obtained by the insertion of fluorinated 1,3‐dicarbonyl compounds (II) to benzyne.
ChemInform Abstract: Highly Enantioselective Three‐Component Reactions of tert‐Butyl Diazoacetate with Arylamines and Imines: An Efficient Synthesis of α,β‐Bis(arylamino) Acid Derivatives.
Authors: Jiang Liqin , Zhang Dan , Wang Zhongqing , Hu Wenhao
Published: June 2013

as important structural motifs of natural products and therapeutic agents
ChemInform Abstract: Redox‐Controlled Selectivity of C—H Activation in the Oxidative Cross‐Coupling of Arenes.
Authors: Cambeiro Xacobe C. , Boorman Tanya C. , Lu Pengfei , Larrosa Igor
Published: June 2013

Electron‐poor and electron‐rich arenes are readily converted to the corresponding biaryls through double C—H activation whereby one arene is used as an arylgold complex.
ChemInform Abstract: Facile Synthesis of 2‐Arylphenols via Palladium‐Catalyzed Cross‐Coupling of Aryl Iodides with 6‐Diazo‐2‐cyclohexenones.
Authors: Yang Ke , Zhang Jun , Li Yun , Cheng Bin , Zhao Liang , Zhai Hongbin
Published: June 2013

The new approach for the synthesis of a wide range of the title compounds is developed.
ChemInform Abstract: Palladium‐Supported Hybrid Cellulose—Aluminum Oxide Composite for Suzuki—Miyaura Cross‐Coupling Reaction.
Authors: Kumbhar Arjun , Jadhav Sanjay , Kamble Santosh , Rashinkar Gajanan , Salunkhe Rajashri
Published: June 2013

The robust catalyst allows the synthesis of various biphenyls from aryl bromides in an aqueous medium.
ChemInform Abstract: Alkenylation of 1‐ and 2‐Naphthols by Using Magnesium Alkylidene Carbenoids as Electrophilic Alkenylating Agents.
Authors: Kimura Tsutomu , Watanabe Masaya , Kashiwamura Gaku , Sakurada Jo , Satoh Tsuyoshi
Published: June 2013

The procedure provides various C‐alkenylated naphthols regioselectively.
ChemInform Abstract: Asymmetric Synthesis of trans‐Dihydroarylfurans in a Friedel—Crafts/Substitution Domino Reaction under Squaramide Catalysis.
Authors: Jarava‐Barrera Carlos , Esteban Francisco , Navarro‐Ranninger Carmen , Parra Alejandro , Aleman Jose
Published: June 2013

Enantiopure trans‐dihydroarylfurans (II), (V) and (VII) are synthesized from (Z)‐bromonitroalkenes (II) and naphthol (I) or phenol derivatives (IV) and (VI), resp., in good yields and high enantioselectivity by using a squaramide catalyst.
ChemInform Abstract: Synthesis of 3‐Acylindoles by Palladium‐Catalyzed Acylation of Free (N—H) Indoles with Nitriles.
Authors: Jiang Tao‐Shan , Wang Guan‐Wu
Published: June 2013

An efficient protocol for the title synthesis is successfully developed for broad scope of indoles.
ChemInform Abstract: (.+‐.)‐CSA‐Catalyzed Friedel—Crafts Alkylation of Indoles with 3‐Ethoxycarbonyl‐3‐hydroxyisoindolin‐1‐one: An Easy Access of 3‐Ethoxycarbonyl‐3‐indolylisoindolin‐1‐ones Bearing a Quaternary α‐Amino Acid Moiety.
Authors: Srivastava Anvita , Singh Shivendra , Samanta Sampak
Published: June 2013

The approach is advantageous with regards to simple operation, mild conditions, and high yields.
ChemInform Abstract: Unexpected Formation of Pyrrolo[1,2‐a]quinoxaline Derivatives During the Multicomponent Synthesis of Pyrrolo[1,2‐a]benzimidazoles.
Authors: Nicolescu Alina , Deleanu Calin , Georgescu Emilian , Georgescu Florentina , Iurascu Ana‐Maria , Shova Sergiu , Filip Petru
Published: June 2013

Three‐component reaction of N‐benzylbenzimidazole (I), α‐bromoacetophenones and carbonyl‐activated alkynes gives pyrrolobenzimidazoles (IV) in refluxing 1,2‐epoxybutane.
ChemInform Abstract: Stereochemical Control on the Michael Addition of Chiral 1,3‐Oxazolidine‐2‐thiones to N‐Crotonyl 1,3‐Oxazolidin‐2‐ones.
Authors: Munive Laura , Dzakuma Sena A. , Olivio Horacio F.
Published: June 2013

Conjugated addition of non‐chiral oxazolidinethione (II) to chiral N‐crotonyl oxazolidinones proceeds with poor diastereoselectivity.
ChemInform Abstract: Enantioselective Construction of Spirooxindole Derivatives Through [3 + 2] Annulation Catalyzed by a Bisthiourea as a Multiple‐Hydrogen‐Bond Donor.
Authors: Shi Yan , Lin Aijun , Mao Haibin , Mao Zhijie , Li Weipeng , Hu Hongwen , Zhu Chengjian , Cheng Yixiang
Published: June 2013

The products with three contiguous stereocenters including one spiroquaternary center are obtained with excellent dia‐ and enantioselectivity.
ChemInform Abstract: Study on the Tandem Synthesis of Optically Active 2‐Substituted 4 (or 5)‐Phenyl‐1,3‐oxazolines.
Authors: Jiang Haizhen , Lu Wenjun , Cai Yeshan , Wan Wen , Wu Shaoxiong , Zhu Shizheng , Hao Jian
Published: June 2013

The proposed mechanism for this reaction involves an aziridine intermediate with the acidities of the carboxylic acids playing a key role in the selective formation of various intermediates.
ChemInform Abstract: Catalytic Asymmetric Synthesis of Cyclic Sulfamides from Conjugated Dienes.
Authors: Cornwall Richard G. , Zhao Baoguo , Shi Yian
Published: June 2013

The title reaction proceeds with high regioselectivity toward the internal double bond whereas double bonds in the alkyl group remain unaffected [viz.
ChemInform Abstract: Straightforward Method for Regioselective Reduction of 3‐Acyl‐Substituted 2‐(Trifluoromethyl)‐2H‐chromen‐5‐one and Chromane Scaffolds in NaBH4/Ethanol Medium.
Authors: Bonacorso Helio G. , Navarini Jussara , Luz Fabio M. , Whietan Carson W. , Junges Andrizia F. , Cavinatto Susiane , Martins Marcos A. P. , Zanatta Nilo
Published: June 2013

Reduction of the title 3‐acylchromenones (I) with NaBH4 in EtOH regio‐ and stereoselectively affords 8a‐hydroxyoctahydrochromenones (II).
ChemInform Abstract: Copper‐Catalyzed Asymmetric Conjugate Addition of Alkenyl‐ and Alkylalanes to α,β‐Unsaturated Lactams.
Authors: Cottet Pierre , Mueller Daniel , Alexakis Alexandre
Published: June 2013

The title reaction provides valuable building blocks for the preparation of optically active N‐containing heterocycles.
ChemInform Abstract: Cu‐Mediated Selective O‐Arylation on C‐6 Substituted Pyridin‐2‐ones.
Authors: Chen Taijie , Huang Qingqing , Luo Yu , Hu Youhong , Lu Wei
Published: June 2013

Optimized conditions are developed for the Chan—Evans—Lam cross‐coupling of pyridin‐2‐ones with arylboronic acids to yield the O‐arylated products selectively.
ChemInform Abstract: Synthesis of Selective Inhibitors of Sphingosine Kinase 1.
Authors: Baek Dong Jae , MacRitchie Neil , Pyne Nigel J. , Pyne Susan , Bittman Robert
Published: June 2013

Among the novel compounds screened for their inhibitory potency against sphingosine kinase 1, derivative (IIIb) exhibits the highest activity.
ChemInform Abstract: Palladium‐Catalyzed Desulfitative Arylation of 3‐Haloquinolines with Arylsulfinates.
Authors: Colomb Julie , Billard Thierry
Published: June 2013

Conditions A) are elaborated as the most efficient ones: halogenated nitrogen heteroarenes substituted at the aryl moiety afford moderate to good yields of the desired compounds.
ChemInform Abstract: Carbophilic 3‐Component Cascades: Access to Complex Bioactive Cyclopropyl Diindolylmethanes.
Authors: Groome Nigel M. , Elboray Elghareeb E. , Inman Martyn W. , Dondas H. Ali , Phillips Roger M. , Kilner Colin , Grigg Ronald
Published: June 2013

Cycloisomerization of nitrogen‐tethered 1,6‐dienynes is catalyzed by PtCl2 and affords the corresponding azabicyclo[4.1.0]hept‐4‐enes [viz.
ChemInform Abstract: Regioselective Bromination of Fused Heterocyclic N‐Oxides.
Authors: Wengryniuk Sarah E. , Weickgenannt Andreas , Reiher Christopher , Strotman Neil A. , Chen Ke , Eastgate Martin D. , Baran Phil S.
Published: June 2013

A simple, mild, and scalable method for the title reaction is presented which can also be extended to complex molecules [e.g. the antimalarial agent (XIV)] and the incorporation of chlorine using Bu4NCl [viz.
ChemInform Abstract: Regioisomeric 4‐Amino‐ and 6‐Aminopyrazolo[3,4‐b]pyridines: Synthesis and Structure Determination by NMR Spectroscopy and X‐Ray Diffraction.
Authors: Petrov A. A. , Kasatochkin A. N. , Emelina E. E. , Haukka M.
Published: June 2013

Heating 5‐aminopyrazoles (I) with ethoxymethylidenemalononitrile in refluxing MeOH selectively affords 4‐aminopyrazolopyridines (III).
ChemInform Abstract: A New Series of C‐6 Unsubstituted Tetrahydropyrimidines: Convenient One‐Pot Chemoselective Synthesis, Aggregation‐Induced and Size‐Independent Emission Characteristics.
Authors: Zhu Qiuhua , Huang Lan , Chen Zhipeng , Zheng Sichao , Lv Longyun , Zhu Zhibo , Cao Derong , Jiang Huanfeng , Liu Shuwen
Published: June 2013

Title compounds are directly synthesized via a convenient urea‐catalyzed chemoselective multicomponent reaction under mild conditions.
ChemInform Abstract: Electrocatalytic and Chemical Methods in MHIRC Reactions: The First Example of the Multicomponent Assembly of Medicinally Relevant Spirocyclopropylbarbiturates from Three Different Molecules.
Authors: Vereshchagin Anatolii N. , Elinson Michail N. , Dorofeeva Evgeniya O. , Stepanov Nikita O. , Zaimovskaya Tatiana A. , Nikishin Gennady I.
Published: June 2013

Electrolysis of barbituric acids, malononitrile and aromatic aldehydes in an undivided cell in the presence of sodium bromide results in a Michael halogenation initiated ring closure (MHIRC) reaction yielding spirocyclopropylbarbiturates (IV).
ChemInform Abstract: Direct Access to Novel Chromeno—Pyrimidine N‐Oxides via Tandem Base‐Catalyzed Double Nucleophilic Addition/Dehydration Reaction.
Authors: Jalli Venkata Prasad , Jaggavarapu Satyanarayana Reddy , Kamalakaran Anand Solomon , Gangisetty Sravan Kumar , Nanubolu Jagadeesh Babu , Gaddamanugu Gopikrishna
Published: June 2013

The process is regioselective to give the target compounds (13 examples) in good yields.
ChemInform Abstract: Catalytic Dehydrogenative Si—N Coupling of Pyrroles, Indoles, Carbazoles as well as Anilines with Hydrosilanes Without Added Base.
Authors: Koenigs C. David F. , Mueller Maria F. , Aiguabella Nuria , Klare Hendrik F. T. , Oestreich Martin
Published: June 2013

An efficient protocol for the base‐free dehydrogenative Si‐N coupling of monohydrosilanes with weakly to moderately nucleophilic NH‐groups is described.
ChemInform Abstract: Cycloaddition of Primary Phosphines to Divinyl Sulfide.
Authors: Gusarova N. K. , Malysheva S. F. , Kuimov V. A. , Belogorlova N. A. , Vashchenko A. V. , Trofimov B. A.
Published: June 2013

A preparative procedure for the synthesis of 4‐substituted 1,4‐thiaphosphinanes (III) via radical‐initiated cycloaddition of primary phosphines to divinyl sulfide is developed.
ChemInform Abstract: Synthesis of Azahomosteroid Ring System Through Intramolecular [4 + 2] Cycloaddition of in situ Generated Azaisobenzofuran Intermediates.
Authors: Roy Priyabrata , Mitra Partha , Ghorai Binay Krishna
Published: June 2013

The reaction of the N‐heterocyclic substrates with carbene complex (II) produces azaisobenzofuran intermediates.
ChemInform Abstract: Applications of Thiyl Radical Cyclizations for the Synthesis of Thiosugars.
Authors: Malone Aoife , Scanlan Eoin M.
Published: June 2013

The first examples of thiyl radical cyclization applied to thiosugar synthesis are given.
ChemInform Abstract: Metal‐Mediated Alkynediol Cycloisomerization: First and Second Generation Formal Total Syntheses of Didemniserinolipid B.
Authors: Das Shyamsundar , Induvadana Boddeti , Ramana C. V.
Published: June 2013

A formal total synthesis of didemniserinolipid B (III), a natural serinolipid first isolated from the tunicate Didemnum sp., is developed by employing a regioselective metal‐mediated 6‐endo‐dig alkynol‐cycloisomerization reaction as the key step.
ChemInform Abstract: Oxide‐Oxide Reactions in the Solid State
Authors: Spinolo Giorgio , Tredici Ilenia G. , Pin Sonia
Published: June 2013

Review: 146 refs.
ChemInform Abstract: ARPES. A Probe of Electronic Correlations
Authors: Comin Riccardo , Damascelli Andrea
Published: June 2013

Review: (ARPES: angle‐resolved photoemission spectroscopy) emphasis on transition metaoxides; 128 refs.
ChemInform Abstract: Carboranylamidinates
Authors: Edelmann Frank T.
Published: June 2013

Review: synthesis, structure, and application as polyfunctional ligand system; < 50 refs.
ChemInform Abstract: Di‐ and Trinuclear Copper(II) Complexes of Polyaza Macrocycles and Cryptands as Anion Receptors
Authors: Mateus Pedro , Lima Luis M. P. , Delgado Rita
Published: June 2013

Review: 81 refs.
ChemInform Abstract: Nucleation of Organic Crystals — A Molecular Perspective
Authors: Davey Roger J. , Schroeder Sven L. M. , ter Horst Joop H.
Published: June 2013

Review: 106 refs.
ChemInform Abstract: Click Chemistry on Nano‐Surfaces
Authors: He Hongkun , Gao Chao
Published: June 2013

Review: 147 refs.
ChemInform Abstract: Molecular Diversity Through Novel Organosulfur Synthons. Versatile Templates for Heterocycle Synthesis
Authors: Ila Hiriyakkanavar , Junjappa Hiriyakkanavar
Published: June 2013

Review: 47 refs.
ChemInform Abstract: Oxidation. Haloperoxidases
Authors: Hill A. , Littlechild J.
Published: June 2013

Review: 71 refs.
ChemInform Abstract: Asymmetric Gold‐Catalyzed Reactions
Authors: Huguet Nuria , Echavarren Antonio M.
Published: June 2013

Review: 52 refs.
ChemInform Abstract: C—C Bond Formation Using Lewis Acids and Silicon Enolates
Authors: Kobayashi S. , Yoo W.‐J. , Yamashita Y.
Published: June 2013

Review: 109 refs.
ChemInform Abstract: C—C Bond‐Forming Reactions via the Heck Reaction
Authors: Uozumi Y.
Published: June 2013

Review: 84 refs.
ChemInform Abstract: C—C Bond Formation: Mannich Reaction
Authors: Akiyama T.
Published: June 2013

Review: 133 refs.
ChemInform Abstract: Transition Metal Catalyzed C—H Functionalization. Synthetically Enabling Reactions for Building Molecular Complexity
Authors: Engle Keary M. , Yu Jin‐Quan
Published: June 2013

Review: 198 refs.
ChemInform Abstract: Magnetic Chirality as Probed by Neutron Scattering
Authors: Simonet V. , Loire M. , Ballou R.
Published: June 2013

Review: 77 refs.
ChemInform Abstract: Integral Equations in the Study of Polar and Ionic Interaction Site Fluids
Authors: Howard Jesse J. , Pettitt B. Montgomery
Published: June 2013

Review: 114 refs.
ChemInform Abstract: Micelles: Chemical Kinetics
Authors: Bunton Clifford A.
Published: June 2013

Review: 85 refs.
ChemInform Abstract: Electronic Structure and Chemical Properties of Lithium Organics Seen Through the Glasses of Charge Density
Authors: Leusser Dirk
Published: June 2013

Review: 48 refs.
ChemInform Abstract: Self‐Assembled Vesicles with Functionalized Membranes
Authors: Gruber Benjamin , Koenig Burkhard
Published: June 2013

Review: 68 refs.
ChemInform Abstract: Carbon Nanomaterials for Electronics, Optoelectronics, Photovoltaics, and Sensing
Authors: Jariwala Deep , Sangwan Vinod K. , Lauhon Lincoln J. , Marks Tobin J. , Hersam Mark C.
Published: June 2013

Review: 537 refs.
ChemInform Abstract: Nanoparticle Assemblies: Dimensional Transformation of Nanomaterials and Scalability
Authors: Xu Liguang , Ma Wei , Wang Libing , Xu Chuanlai , Kuang Hua , Kotov Nicholas A.
Published: June 2013

Review: 107 refs.
ChemInform Abstract: Green Chemistry: Why and How — For Sustainable Chemical Industry and Environmentally Commendable Civilization
Authors: Patil Harshada I. , Singh Meera C. , Gaikwad Preeti , Lade Kedar S. , Gadhave Nilam A. , Sawant Sanjay D.
Published: June 2013

Review: 37 refs.
ChemInform Abstract: Physico‐Chemical Foundations Underpinning Microarray and Next Generation Sequencing Experiments
Authors: Harrison Andrew , Binder Hans , Buhot Arnaud , Burden Conrad J. , Carlon Enrico , Gibas Cynthia , Gamble Lara J. , Halperin Avraham , Hooyberghs Jef , Kreil David P. , et al. et al.
Published: June 2013

Review: 92 refs.
ChemInform Abstract: The Mechanism for Transition Metal Catalyzed Hydrochalcogenation of Unsaturated Organic Molecules
Authors: Ishii Akihiko , Nakata Norio
Published: June 2013

Review: 68 refs.
ChemInform Abstract: Phase Transfer Catalysis ‐ Basic Principles, Mechanism and Specific Features
Authors: Makosza Mieczyslaw , Fedorynski Michal
Published: June 2013

Review: 82 refs.
ChemInform Abstract: Chromogenic and Fluorogenic Chemosensors and Reagents for Anions. A Comprehensive Review of the Years 2010—2011
Authors: Santos‐Figueroa Luis E. , Moragues Maria E. , Climent Estela , Agostini Alessandro , Martinez‐Manez Ramon , Sancenon Felix
Published: June 2013

Review: 359 refs.
Carboligation Reactions Mediated by Benzoylformate Decarboxylase Immobilized on a Magnetic Solid Support
Authors: Tural Bilsen , Tural Servet , Demir Ayhan S.
Published: June 2013

In this study, magnetic nanoparticles (Fe3O4, magnetite) with immobilized metal affinity ligands (MSS) were prepared and characterized by X‐ray diffraction (XRD), transmission electron microscopy (TEM), fourier transform infrared spectroscopy (FTIR), and vibrating‐sample magnetometer (VSM) methods for purification and immobilization of the histidine‐tagged recombinant benzoylformate decarboxylase (BFD). The MSS support was shown to be eligible for selective binding of HIS‐tagged BFD by SDS‐page analysis. Loading capacity of the MSS support was determined as 43.6 ± 1.1 mg/g. The regeneration ability for protein binding was also studied. An immobilized BFD was tested to catalyze benzoin condensation and representative cross acyloin reaction. Conversion and enantiomeric excess values were comparable with that of free enzyme catalyzed reactions. Chirality 25:415–421, 2013. © 2013 Wiley Periodicals, Inc.
Inhibition of Leishmania infantum Trypanothione Reductase by Azole‐Based Compounds: a Comparative Analysis with Its Physiological Substrate by X‐ray Crystallography
Authors: Baiocco Paola , Poce Giovanna , Alfonso Salvatore , Cocozza Martina , Porretta Giulio Cesare , Colotti Gianni , Biava Mariangela , Moraca Francesca , Botta Maurizio , Yardley Vanessa , Fiorillo Annarita , Lantella Antonella , Malatesta Francesco , Ilari Andrea
Published: June 2013

Herein we report a study aimed at discovering a new class of compounds that are able to inhibit Leishmania donovani cell growth. Evaluation of an in‐house library of compounds in a whole‐cell screening assay highlighted 4‐((1‐(4‐ethylphenyl)‐2‐methyl‐5‐(4‐(methylthio)phenyl)‐1H‐pyrrol‐3‐yl)methyl)thiomorpholine (compound 1) as the most active. Enzymatic assays on Leishmania infantum trypanothione reductase (LiTR, belonging to the Leishmania donovani complex) shed light on both the interaction with, and the nature of inhibition by, compound 1. A molecular modeling approach based on docking studies and on the estimation of the binding free energy aided our rationalization of the biological data. Moreover, X‐ray crystal structure determination of LiTR in complex with compound 1 confirmed all our results: compound 1 binds to the T(SH)2 binding site, lined by hydrophobic residues such as Trp21 and Met113, as well as residues Glu18 and Tyr110. Analysis of the structure of LiTR in complex with trypanothione shows that Glu18 and Tyr110 are also involved in substrate binding, according to a competitive inhibition mechanism.
Solution‐Processable Graphene Quantum Dots
Authors: Zhou Xuejiao , Guo Shouwu , Zhang Jingyan
Published: June 2013

This minireview describes recent progress in solution‐processable graphene quantum dots (SGQDs). Advances in the preparation, modification, properties, and applications of SGQDs are highlighted in detail. As one of emerging nanostructured materials, possible ongoing research related to the precise control of the lateral size, edge structure and surface functionality; the manipulation and characterization; the relationship between the properties and structure; and interfaces with biological systems of SGQDs have been speculated upon.
In Vivo Magnetic Resonance Imaging Detection of Paramagnetic Liposomes Loaded with Amphiphilic Gadolinium(III) Complexes: Impact of Molecular Structure on Relaxivity and Excretion Efficiency
Authors: Cittadino Evelina , Botta Mauro , Tei Lorenzo , Kielar Filip , Stefania Rachele , Chiavazza Enrico , Aime Silvio , Terreno Enzo
Published: June 2013

The magnetic resonance imaging (MRI) performance of two liposome formulations incorporating amphiphilic 1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetraacetic acid (DOTA)‐like GdIII complexes has been investigated both in vitro and in vivo. The complexes differ in one donor group of the coordination cage (carboxylate versus carboxoamide), and in the length (C12 versus C18) and the point of attachment of the aliphatic chains to the chelators. The in vitro 1H relaxometric characterisation of the systems, performed with a newly developed relaxation model that takes into account the contributions of the GdIII chelates pointing in‐ and outwards of the liposome, indicates that their efficacy is optimal in the range 0.5–1.5 T. The tetracarboxylic C12‐containing liposomes (LIPO‐GdDOTA(GAC12)2; GA=glutaric acid) are four‐fold more efficient than the monoamide C18‐based analogue (LIPO‐GdDOTAMA(C18)2). Such a difference is also found in vivo at 1 T in a melanoma tumour model on mice. A few hours after intravenous injection, the T1 contrast enhancement in the organs where the nanovesicles typically distribute (liver, spleen, kidneys and tumour) is much higher for LIPO‐GdDOTA(GAC12)2. Interestingly, after about 7 h post‐injection the contrast enhancement observed for the more efficient liposomes decreases rapidly and becomes lower than for LIPO‐GdDOTAMA(C18)2. The relaxometric data and the quantification of the GdIII complexes in the organs, determined ex vivo by inductively coupled plasma mass spectrometry, indicate that: 1) the differences in the contrast enhancement can be attributed to the different rate of water exchange and rotational dynamics of the Gd complexes, and 2) the rapid contrast decrease is caused by a faster clearance of GdDOTA(GAC12)2 from the organs. This is also confirmed by using a newly synthesised amphiphilic cyanine‐based fluorescent probe (Cy5‐(C16)2). As one of the main limitations for the clinical translation of liposomes incorporating amphiphilic imaging agents is related to their very long persistence in the body, the results reported herein suggest that the clearance of the probes can be accelerated, without compromising their role, by a proper selection of the lipophilic portion of the incorporated compound as well as of the ligand site at which the aliphatic tails are linked. Then, GdDOTA(GAC12)2 complex may represent a good candidate for the development of improved MRI protocols based on paramagnetically labelled lipidic nanoparticles.
An enhanced XOR‐based scheme for wireless packet retransmission problem
Authors: Gao Zhenguo , Xiang Weidong , Tan Guozhen , Yao Nianmin , Li Peihua
Published: June 2013

Solving wireless packet retransmission problem (WPRTP) using network coding (NC) is increasingly attracting research efforts. However, existing NC‐based schemes for WPRTP are with high computational complexity resulting from computation on larger Galois field (GF(2q)), or the solutions on GF(2) found by the schemes are less efficient. In this paper, combining the basic ideas in two existing schemes, denoted as ColorNC and CliqueNC, respectively, we present a new scheme named as ColorCliqueNC. The advantages of ColorCliqueNC include the following: (i) it is suitable for all kinds of WPRTP instances; (ii) it works on GF(2); thus, it is computationally efficient than the schemes working on larger Galois fields; and (iii) the solutions found by ColorCliqueNC usually have fewer packet retransmissions than those by ColorNC and CliqueNC despite that they all work on GF(2). Theoretical analysis indicates that ColorCliqueNC is superior to ColorNC and CliqueNC. Simulation results show that ColorCliqueNC generally outperforms ColorNC and CliqueNC. Compared with ColorNC, ColorCliqueNC can save up to 10% packet retransmissions. Copyright © 2013 John Wiley & Sons, Ltd.
Binge/purge thoughts in nonsuicidal self‐injurious adolescents: An ecological momentary analysis
Authors: Shingleton Rebecca M. , Eddy Kamryn T. , Keshaviah Aparna , Franko Debra L. , Swanson Sonja A. , Yu Jessica S. , Krishna Meera , Nock Matthew K. , Herzog David B.
Published: June 2013

Objective

Adolescents who self‐injure often engage in bingeing/purging (BP). Ecological momentary assessment (EMA) has potential to offer insight into the relationship between self‐injury and BP. The aims of this study were to examine the frequency and context of BP using EMA in a sample of nonsuicidal self‐injurious (NSSI) adolescents.

Method

Thirty adolescents with a history of NSSI responded to questions regarding self‐destructive thoughts/behaviors using a palm‐pilot device. Descriptive analyses compared thought/behavior contexts during reports of BP and NSSI thoughts/behaviors (occurring together vs. individually).

Results

BP thoughts were present in 22 (73%) participants, occurring on 32% of the person‐days recorded; 59% of these participants actually engaged in BP behavior. Seventy‐nine percent of BP thoughts co‐occurred with other self‐destructive thoughts. Adolescents were more often with friends/peers than alone or with family when having BP thoughts. Worry and pressure precipitated both BP and NSSI thoughts, but perceived criticism and feelings of rejection/hurt were associated more often with BP thoughts than with NSSI thoughts.

Discussion

BP thoughts and behaviors were common in this sample, often occurring with other self‐destructive thoughts. Future EMA research is needed to address the function of BP symptoms, the contextual variables that increase risk for BP thoughts, and the factors that predict the transition of thoughts into behaviors in adolescents with and without self‐injury. © 2013 Wiley Periodicals, Inc. (Int J Eat Disord 2013; 46:684–689)