bluuebunny/crossref_metadata_2025 huggingface dataset:
Thioredoxin-interacting protein TXNIP as a promising diagnostic marker for metabolic-associated fatty liver disease in patients with type 2 diabetes
Authors: Meltonian A. R. , Laevskaya M. Yu. , Savchenkov Yu. N. , Babenko A. Yu.
Published: January 2025

Introduction. Metabolic-associated fatty liver disease (MAFLD) is a common disease that has a pathogenesis-based relationship with type 2 diabetes (T2D).

Aim. To determine the levels of TXNIP protein in patients with MAFLD and T2D who were on metformin monotherapy, to compare these levels with the findings of MRI of the liver, and to assess changes in TXNIP protein levels six months after starting treatment with glucagon-like peptide-1 receptor agonists (GLP-1RA) and sodium-glucose cotransporter-2 (SGLT-2) inhibitors.

Materials and methods. The study included 49 patients (34 female and 15 male) with T2D and MAFLD, aged 55 ± 8 years, who were followed up at the outpatient clinic of Almazov National Medical Research Centre (St. Petersburg) from January 2023 to March 2024. The eligibility criteria included BMI values of 25–40 kg/m² and a glycated hemoglobin level not exceeding 9.5%. Results. The study showed that serum TXNIP protein levels were positively correlated with the severity of MAFLD assessed based on MRI findings. Furthermore, TXNIP levels significantly decreased as a result of therapy with GLP-1RAs and SGLT-2 inhibitors.

Conclusion. These correlation data suggest that the TXNIP level could be used as a promising diagnostic marker in patients with MAFLD and T2D, both at the stage of diagnostic evaluation and when considering the outcomes of ongoing therapy.
Current approach to the management of adnexal torsion
Authors: Dobrokhotova J. E. , Shchegolev A. A. , Markarov A. E. , Kotomina T. S. , Khlynova S. A. , Dimitrova V. I. , Markova E. A. , Slyusareva O. A.
Published: January 2025

Introduction. In the structure of urgent gynecological practice, ovarian torsion ranks fifth, which is usually diagnosed in women of reproductive age. To date, there is no single standard for assessing the viability of the ovary and choosing a conservative or radical operation for patients with ovarian torsion, in this regard, there is a need to search for potential predictors that determine the validity of the choice of the volume of surgical intervention.

Aim. To optimize management tactics for patients with uterine torsion.

Materials and methods. In a retrospective study, an analysis of 55 case histories of patients admitted to a gynecological hospital with a diagnosis of ovarian torsion was carried out. Depending on the organ-preserving and organ-removing surgical treatment, the patients were divided into two groups. The analysis of the studied indicators was carried out using correlation, regression, factor and ROC analysis.

Results. The results of the study demonstrated that only a visual assessment of the state of the ovarian torsion to unjustified organ-removing interventions in 57.1% of patients. Based on correlation, factor, regression and ROC analysis, diagnostically significant predictors determining the volume of surgical intervention were determined.

Conclusions. Based on the retrospective analysis, an algorithm for managing patients with ovarian torsion was developed: at stages A and B according to the clinical classification of ovarian torsion damage, regardless of the studied criteria, organpreserving treatment – detorsion must be performed; at stage C, special attention is paid to D-dimer values: at D-dimer <1450 ng/ml – detorsion, and only at D-dimer >1490 ng/ml – organ-preserving surgery.
Arterial hypertension is an important risk factor for the development of cognitive and psychoemotional disorders
Authors: Shishkova V. N. , Shishkov V. A. , Vinokurov V. G.
Published: January 2025

In the recent years timely identification and management of cognitive and psychoemotional disorders in patients with the most common chronic non-communicable diseases has acquired special importance. Arterial hypertension (AH) is the most significant factor for the development and progression of cognitive and psychoemotional disorders. The development of AH in young and middle-aged adults is a particularly unfavourable prognostic fact. A search is currently underway for therapeutic neuroprotective strategies that can effectively prevent or reduce the damaging pathophysiological effects of hypertension on the brain. For over almost 30 years of active clinical use of the original ethylmethylhydroxypyridine succinate (EMHPS) the enormous clinical experience and evidence of therapeutic benefits in patients with various types of vascular and metabolic disorders have been accumulated. The principal pharmacological effects of EMHPS are antioxidant, antihypoxic, and membrane-protective, due to which the drug produces nootropic, anxiolytic, vegetative-stabilizing and other clinical effects. The favourable effect of EMHPS on the blood vessel wall, endothelial function and rheological properties has also been confirmed, which presents an important component of the complex therapy of a modern patient with AH. The international multicenter, randomized, double-blind and placebo-controlled study MEMO and its subanalysis showed that EMHPS is significantly effective in improving cognitive functions, anxiety and asthenia levels and patient’s quality of life during the long-term sequential therapy in patients with concomitant hypertension.
Thrombocytopenia in COVID-19 patients: The role of fondaparinux and succinates in improving outcomes (exchange of experience)
Authors: Semigolovskii N. Yu. , Ratnikov V. A. , Simutis I. S. , Svetlikov A. V. , Ermolaeva L. G. , Salygina D. S. , Danilov M. S. , Semigolovskii S. N. , Gorokhov A. A. , Mazurenko M. S.
Published: January 2025

As is known, the new coronavirus infection (NCI) COVID-19 is accompanied by coagulopathy, for the treatment of which heparins are widely used that can cause heparin-induced thrombocytopenia type 2 (HIT), complicated by paradoxical thrombosis. A considerable number of cases of sudden thrombosis after vaccination with Pfizer, Moderna, and Oxford–AstraZeneca vaccines was also described, caused by vaccine-induced “spontaneous HIT syndrome”. An analysis of the medical histories of hospitalized COVID-19 patients (a total of 3,455), showed an 8-fold increase in the frequency of severe thrombocytopenia (<100 × 109/l), compared with patients of the pre-Covid period, and approximately 25% of them can be attributed to the manifestation of HIT. The use of the original Rule of express HIT-diagnostics in the pre-Covid period (“100–5–100”) and the original Algorithm for HIT-treatment (includes the transition to the use of Fondaparinux and succinate-containing drugs), as shown by an earlier our study, made it possible to reduce the frequency of severe thrombotic complications and significantly improve the results of treatment in non-infectious patients. These Rule and Algorithm have been applied in patients with NCI since 2021. The use of these principles partly explains the 3-times decrease of in-hospital mortality in 2021, compared with 2020 (from 18.0% to 6.7%), that coincides with an increase in the use of Fondaparinux and succinate-containing preparations in hospital. Thus, the application of the described Rule and Algorithm in the treatment of patients with NCI COVID-19 increases the effectiveness of treatment and reduces hospital mortality.
Composição química e mineral do conteúdo ruminal de caprinos criados extensivamente no município de Mossoró/RN
Authors:   , Gameleira Jucélio da Silva
Published: January 2025

irregularidade na distribuição e o curto período das chuvas provocam
alterações quantitativas e qualitativas no suporte forrageiro da caatinga, contribuindo
para incidência de doenças carências e metabólicas, necessitando de estudo do efeito da
sazonalidade sobre a composição química e mineral do conteúdo ruminal de caprinos
criados extensivamente no semiárido do Rio Grande do Norte. Foram utilizados 40
caprinos machos, com 6 meses de idade, sem padrão racial definido, castrados, pesando
aproximadamente 20 kg, divididos em dois grupos: mineralizados (M) e sem
mineralização (SM) e mantidos em propriedade no município de Mossoró-RN, onde
estes pastejavam durante o dia em área de caatinga e eram recolhidos à noite em
aprisco. A coleta do conteúdo ruminal foi realizada em quatro períodos distintos: mês
de janeiro (final do período seco), abril (meio do período chuvoso), julho (início do
período seco) e outubro (meio do período seco) para avaliação da composição química
(proteína bruta, material mineral, estrato etéreo, fibra em detergente neutro e ácido,
nutrientes digestíveis totais, celulose e hemicelulose) e dos minerais (Ca, Mg, P, Na, K,
Cu, Zn, N, Co e Mn). Os valores da composição química foram todos normais, com
destaque para proteína que foi acima de 10 % em todos os períodos. Os minerais
apresentaram-se em quantidades variadas entre os períodos, com valores menores no
período Mc sem influência da mineralização para todos os períodos. O conteúdo
ruminal apresentou composição química e mineral satisfatório em todos os períodos
avaliados atendendo as exigências nutricionais, sugerindo a qualidade nutricional da
vegetação nativa da caatinga.
Measuring Options for Customary Land Registration From the Perspective of East Nusa Tenggara Findings
Authors: Chamdani Muchammad Chanif
Published: January 2025

This article identifies various options for administering the lands of customary law communities (MHA) that have been implemented or are enshrined in laws and regulations regarding the land sector in Indonesia and sees in what cases specific administration options can be implemented and what the possible challenges are. This research refers to secondary data from findings from the Inventory and Identification of Customary Land in 2021, especially in the province of East Nusa Tenggara. The research also uses a normative approach by examining laws and regulations regarding MHA land registration in the land sector. Based on rules and regulations in the land sector in Indonesia, there are several options for administering MHA lands, namely delineation of land parcels, registration of property rights, registration of communal rights, registration in the land register, and registration in the land management rights (HPL).
Strong Sustainability and Ocean Justice: Fostering Coastal Community Well-Being in Indonesia
Authors: Tarigan Muhammad Insan , Ferdinanto Tonny
Published: January 2025

Poverty and environmental issues are interconnected and entangled in complex human-environment relationships. Poor people often degrade the environment to meet present needs at the expense of their future benefits. Conversely, environmental degradation exacerbates poverty by deteriorating livelihoods, income, and health. This nexus is prevalent in coastal communities’ interactions with coastal and ocean ecosystems. The severe environmental degradation of coastal habitats and oceans endangers coastal communities whose livelihoods depend on marine ecosystem services. Millions of people depend directly on marine resources as their main source of food and income. Indonesia has the second-largest coastline in the world, stretching approximately 81,000 kilometres. Unfortunately, the threat to the sustainability of marine biodiversity is getting more complex. Strengthening the capacity of coastal communities as key actors in managing and protecting coastal sustainability can ensure their well-being. This article identifies and proposes a robust regulatory framework for ocean justice in Indonesia’s coastal regions. A conceptual approach is employed to achieve this goal, with a review of pertinent legal literature and documents. In addition, the critical legal studies method will be utilised to identify potential areas for improvement. It can be argued that Indonesia has yet to achieve the robust sustainability level currently being sought. The concept of strong sustainability is grounded in two fundamental moral principles: environmental ethics and distributive justice. The legal apparatus governing ocean management must be modified to address evolving governance challenges. Although robust sustainability is not the sole determining factor of community well-being, the institutionalisation of ocean justice has the potential to facilitate the actualisation of community well-being in Indonesia's coastal regions.
Oferta institucional de recursos didácticos digitales para la inclusión en secundaria: Un análisis comparativo en el estado español
Authors: Vidal Esteve María Isabel , González González Miriam , Parada Gañete Ana , Marín-Suelves Diana
Published: January 2025

En la actualidad, tanto en la sociedad como en la escuela, impera el principio de inclusión en base al que todas y todos tenemos derecho a estar, participar y aprender en contextos ordinarios. Uno de los elementos fundamentales en el diseño de los procesos de enseñanza y aprendizaje son los recursos didácticos que se seleccionan o crean por parte de los docentes para su uso, tanto dentro como fuera de los centros escolares. Desde esta perspectiva, en esta investigación se ha analizado la oferta institucional de recursos didácticos digitales para la atención a la diversidad en la etapa de Educación Secundaria Obligatoria, de tres comunidades autónomas del estado español: la Comunitat Valenciana, Galicia y las Islas Canarias. Los resultados del Estudio I del proyecto titulado Materiales didácticos digitales en educación secundaria obligatoria: análisis y propuestas para su uso escolar y sociofamiliar (PID2022-1373660B-100) muestran la dispersión en lo que se entiende por inclusión, es decir, la falta de coherencia en el concepto. También se evidencia que la elaboración de los materiales, en demasiadas ocasiones, se produce desde un enfoque centrado en el déficit y con escasa profundización en propuestas diseñadas desde el DUA, y para una aplicación transversal. Por tanto, se concluye que es fundamental profundizar en la formación del profesorado para hacer posible la inclusión y se ofrecen una serie de recomendaciones para la selección, uso y creación de recursos digitales para el alumnado de la etapa de Educación Secundaria Obligatoria.
Sentencing Mentally Disordered Offenders: comparing provisions in Türkiye, England and Wales, and the Netherlands to the ECHR framework
Authors: Yilmaz Candan
Published: January 2025

This publication offers a unique comparative analysis of the sentencing of mentally disordered offenders in Türkiye, England and Wales, and the Netherlands, exploring the alignment of these systems with the European Convention on Human Rights (ECHR). While the presence of mental disorders impacts criminal responsibility, the legal responses and practices differ significantly across jurisdictions.
The complex sanctioning system in Türkiye faced substantial challenges due to the absence of secure forensic psychiatric facilities until 2018. Despite legal mandates, mentally disordered offenders were often either released or unlawfully detained in prisons, creating a prolonged gap between law and practice. The research highlights how the situation evolved and assesses the lingering issues, which were exacerbated by delays during the COVID-19 pandemic.
In order to contextualize the criminal justice system of Türkiye, comparisons are drawn with the criminal justice systems of the Netherlands and England and Wales, two jurisdictions which have distinct and unique frameworks for mentally disordered offenders. The eminent TBS (terbeschikkingstelling) system of the Netherlands and the bifurcated sentencing approach in England and Wales provide valuable points of reference.
This publication is of significance in the field of legal academic literature given the paucity of research on the Turkish criminal justice system, carried out in languages other than Turkish. It evaluates the degree to which these systems adhere to or deviate from ECHR standards, thereby providing insights that facilitate improved compliance with human rights requirements. By bridging comparative legal traditions and identifying best practices, this research holds significant societal and academic relevance.
The Moderated Mediating Effects of Social Media Identity and Loneliness on the Relationship Between Problematic Internet Use and Mental Health in China: Nationwide Cross-Sectional Questionnaire Study
Authors: Liu Chenxi , Liu Yushu , Liu Chaojie , Lin Rujiao , Wang Xi , Zhang Xinyi , Wu Yibo , Wang Dan
Published: January 2025

Background

Mental health disorders are a major public health challenge, and problematic internet use (PIU) may play an important role in this issue. However, the underlying mechanisms of PIU and its effects on mental health have not yet been elucidated.

Objective

This study examines the mediating effect of loneliness on the relationship between PIU and mental health, as well as the moderating effect of social media identity on the relationships among PIU, loneliness, and mental health.

Methods

A cross-sectional questionnaire survey was conducted on 21,292 participants recruited using a multistage stratified sampling strategy from 31 provinces/regions in mainland China from June 20 to August 31, 2022. This study assesses PIU (PIU questionnaire-short form-6), depression (9-item Patient Health Questionnaire [PHQ-9]), anxiety (7-item Generalized Anxiety Disorder scale [GAD-7]), loneliness (3-item loneliness scale), and social media identity (identity bubble reinforcement scale). Additionally, we collected the sociodemographic characteristics of the participants. Participants whose total score of PHQ-9≥15 or total score of GAD-7≥10 were considered to have moderate or severe symptoms of depression or anxiety, respectively. A moderated mediation model was established to examine the mediating effect of loneliness on the association between PIU and mental health outcomes (depression and anxiety), moderated by social media identity.

Results

Approximately 22.80% (4854/21,292) and 14.20% (3023/21,292) of the respondents reported moderate or severe symptoms of depression and anxiety, respectively. Loneliness significantly mediated the association between PIU and mental health outcomes, explaining 42.53% and 45.48% of the total effect of PIU on depression and anxiety, respectively. Social media identity significantly moderated the associations between PIU and depression (β=0.002, 95% CI 0.001-0.002), PIU and anxiety (β=0.001, 95% CI 0.000-0.002), loneliness and depression (β=0.010, 95% CI 0.007-0.013), and loneliness and anxiety (β=0.007, 95% CI 0.004-0.010), but not between PIU and loneliness (β=0.000, 95% CI –0.003 to 0.003). Higher levels of social media identity were significantly associated with lower levels of loneliness (β=–0.018, 95% CI –0.020 to –0.016).

Conclusions

Addressing loneliness may serve as a valuable approach to mitigate the impact of PIU on mental health outcomes. However, social media identity poses a significant challenge in addressing health issues linked to PIU.
Spatiotemporal Correlation Analysis for the Incidence of Esophageal and Gastric Cancer From 2010 to 2019: Ecological Study
Authors: Cui Zixuan , Suo Chen , Zhao Yidan , Wang Shuo , Zhao Ming , Chen Ruilin , Lu Linyao , Zhang Tiejun , Chen Xingdong
Published: January 2025

Background

Esophageal and gastric cancer were among the top 10 most common cancers worldwide. In addition, sex-specific differences were observed in the incidence. Due to their anatomic proximity, the 2 cancers have both different but also shared risk factors and epidemiological features. Exploring the potential correlated incidence pattern of them, holds significant importance in providing clues in the etiology and preventive strategies.

Objective

This study aims to explore the spatiotemporal correlation between the incidence patterns of esophageal and gastric cancer in 204 countries and territories from 2010 to 2019 so that prevention and control strategies can be more effective.

Methods

The data of esophageal and gastric cancer were sourced from the Global Burden of Disease (GBD). Spatial autocorrelation analysis using Moran I in ArcGIS 10.8 (Esri) was performed to determine spatial clustering of each cancer incidence. We classified different risk areas based on the risk ratio (RR) of the 2 cancers in various countries to the global, and the correlation between their RR was evaluated using Pearson correlation coefficient. Temporal trends were quantified by calculating the average annual percent change (AAPC), and the correlation between the temporal trends of both cancers was evaluated using Pearson correlation coefficients.

Results

In 2019, among 204 countries and territories, the age-standardized incidence rates (ASIR) of esophageal cancer ranged from 0.91 (95% CI 0.65-1.58) to 24.53 (95% CI 18.74-32.51), and the ASIR of gastric cancer ranged from 3.28 (95% CI 2.67-3.91) to 43.70 (95% CI 34.29-55.10). Malawi was identified as the highest risk for esophageal cancer (male RR=3.27; female RR=5.19) and low risk for gastric cancer (male RR=0.21; female RR=0.23) in both sexes. Spatial autocorrelation analysis revealed significant spatial clustering of the incidence for both cancers (Moran I>0.20 and P<.001). A positive correlation between the risk of esophageal and gastric cancer was observed in males (r=0.25, P<.001). The ASIR of both cancers showed a decreasing trend globally. The ASIR for esophageal and gastric cancer showed an AAPC of −1.43 (95% CI −1.58 to −1.27) and −1.76 (95% CI −2.08 to −1.43) in males, and −1.93 (95% CI −2.11 to −1.75) and −1.79 (95% CI −2.13 to −1.46) in females. In addition, a positive correlation between the temporal trends in ASIR for both cancers was observed at the global level across sexes (male r=0.98; female r=0.98).

Conclusions

Our study shows that there was a significant spatial clustering of the incidence for esophageal and gastric cancer and a positive correlation between the risk of both cancers across countries was observed in males. In addition, a codescending incidence trend between both cancers was observed at the global level.
Reconstructing the Chinese Female Image of the Other: A 16th-Century Spanish and Portuguese Missionary Ethnographic Perspective
Authors: Bo Gao
Published: January 2025

This paper provides a thorough examination of the depiction of Chinese women in the book The History of the Great and Mighty Kingdom of China, a work by the distinguished Spanish scholar and missionary Juan González de Mendoza. Despite never having visited China, Mendoza managed to compile a thorough depiction of the nation and its people by leveraging the accounts of those who had. This article meticulously examines Mendoza’s representations of Chinese women, an aspect overlooked by previous scholars, aiming to define the specific image he constructed and explore the underlying incentives. Mendoza’s portrayal of Chinese women as opulent, refined, conservative and chaste was influenced by missionaries such as Gaspar da Cruz and Martín de Rada. However, his narrative was distinctively idealised and selective in its representation of Chinese society. A key insight is its “first oppress, then exalt” structure, which first depicts the hardships of lower-class women, before highlighting the social welfare systems of the Ming dynasty. This approach minimised their suffering and emphasised the superiority of Chinese society. It reflects Mendoza’s broader idealisation of China, which served his missionary aims and Europe’s desire for an idealised “other” during times of social and religious upheaval.
A Real-Time Implementation of Smart Voting System Using Face Recognition and Fingerprint Module
Authors: Rajesh Thejeshri
Published: January 2025

Elections are an influential part of any democratic system, and it is indispensable to ensure that the voting process is
conducted in fair means. Conventional paper-based elections are labor-intensive, resource-intensive, and error-prone. In this
case, technology may greatly increase the voting process's accuracy, security, and efficiency. In this, it ist an online voting
system that identifies and authenticates voters using biometric and facial recognition technologies. By removing the need for
physical ballot boxes and enabling voters to cast their ballots remotely, the proposed technology lowers the expense and duration
of the voting process. The method operates by collecting the voter's facial picture and fingerprints and sending them to the server
unit for verification. The server matches the face picture to the information in the database to verify the voter's identification.
Voters are permitted to cast their ballots if their identities are confirmed; if not, they are prohibited from doing so and an error
notice appears on the screen. The system is intended to be safe and impenetrable. With the use of fingerprint and facial
recognition technologies, it is more difficult for someone to vote fraudulently by impersonating someone else. Additionally, the
approach guarantees that each voter may only cast one vote and that the voting procedure is carried out in an open and
equitable way. All things considered, the suggested online voting method has several benefits over conventional paper-based
voting systems, such as more effectiveness, lower costs, better security, and greater transparency.
Sales Forecast and Inventory Management Using ML
Authors: Khandhar Ms. Aangi
Published: January 2025

Efficient sales forecasting and management of inventory are some of the most major concerns for businesses in the
modern economic environment, where organizations have to optimize resources with a view to reducing operational costs and
meeting customers' demands. The effort is towards developing a robust predictive model capable of analyzing the trends in sales
and requirements in the area of inventory by applying Machine Learning techniques so that actionable insights can be derived
based on the analyzed information for proper supply chain management.
In fact, the very raison d'être of the premise is to analyzing historical sales data for patterns that can then be used to make
accurate predictions, hence enabling business firms to anticipate changes in demand and adjust inventory levels accordingly.
This paper uses state-of-the-art Machine Learning algorithms-Regression Analysis and Time Series Forecasting models-to
assure precise forecast accuracy. This algorithm will be able to capture seasonality, trends, and anomalies in the salesdata so
that the model adapts to the changing market conditions.
Data preprocessing and feature engineering are done to clean the data and convert it into usable information that enhances the
model's performance by a significant factor. Visualization techniques are carried out to show findings intuitively and
interpretively to stakeholders for effective decision-making. The solution also provided recommendations on the minimum level
of inventory required to be maintained so that overstocking and stockouts are at minimal, resulting in reduced losses on account
of unwanted stocking or on failure of sales.
This paper points out the transformational power of Machine Learning in supply chain optimization, showing how predictive
analytics can drive data-driven decision-making and improve overall operational efficiency. By accurately forecasting sales and
aligning inventory management strategies, businesses can enhance customer satisfaction and maintain a competitive advantage
in dynamic markets.
Social Network Fake Profile Identification
Authors: Subedi Mr. Saroj
Published: January 2025

The social network, a crucial part of our life is plagued by online impersonation and fake accounts .Fake profiles are
mostly used by the intruders to carry out malicious activities such as harming person , identity theft and privacy intrusion in
Online Social Network(OSN). Hence identifying an account is genuine or fake is one of the critical problem in OSN .In this
paper we proposed many classification algorithm like Support Vector Machine algorithm and deep neural network .It also
studies the comparison of classification methods on SpamUser dataset which is used to select the best.
The Foil-Made (Folezh) Rizas Originated From Bryansk: to the Material Turn in Modern Russian Religious Studies
Authors: Davydov I. P. , Sukhova M. S.
Published: January 2025

The object of the study is decoration and votive embellishment of the Russian icons from the mid‑19th to early 21st centuries; the subject of the study is the rizas, halos and crowns of the foil‑made and underfoiled images. The co‑authors see the novelty of the posing the question in two aspects: a) the “Bryansk case” that is clearly limited by one region and has not yet come to the attention of iconologists is used; b) attention is focused not so much on the result of decorating the icon boards with foil, but on the subtleties of the technological process of producing parts from which the finished icon case is constructed, which allows us to distinguish local methods of processing foil and correctly attribute the surviving monuments of folk crafts. The main research methods are maintained within the framework of the material, iconic and semiotic turns in human sciences, with participant observation, description, case study, and complex religious studies as the main methods. The authors come to the conclusion that the current state of the foil (folezh) craft in the Bryansk region allows us to confidently speak about the continuing succession of generations of masters, while the detailed expertise of the processing of foil and available materials contributes to the up‑to‑date museumification and art history attribution of foil‑covered and foil‑covered icons.
Testing the Antioxidant Potential of Mango Leaves (Mangifera indica) from Bandar Khalipah Village, Deli Serdang Regency Using the FRAP Method
Authors: Tambunan Pravil Mistryanto , Sihotang Supran Hidayat
Published: January 2025

This study aims to identify and analyze the antioxidant potential of mango leaves (Mangifera indica) sourced from Bandar Khalipah Village, Deli Serdang Regency. Mango leaves are known to contain various secondary metabolites such as flavonoids, tannins, saponins, alkaloids, glycosides, as well as steroids and triterpenoids, which play a crucial role as natural antioxidants. The extraction process was carried out by maceration using 96% ethanol, yielding a thick extract with a rendement of 117%. Phytochemical screening indicated the presence of active compounds in the mango leaf extract. Antioxidant capacity was measured using the FRAP (Ferric Reducing Antioxidant Power) method, resulting in an average value of 151.7 mgAAE/g extract. These results suggest that mango leaves have significant potential as a natural antioxidant source that can be utilized to prevent damage caused by free radicals in the body. This study reinforces the use of mango leaves as a natural alternative for public health.
Biostatic Activity of Eusiderin I From Eusideroxylon Zwagery Against Sclerotium Rolfsii
Authors: Muhaimin Muhaimin
Published: January 2025

241 (4,99) and 273 (4,83) and the infra-red spectra of this compound showed the sharp aromatic C-H stretching vibration at 3079 cm-1, aliphatic C-H stretching vibration at 2975 and 2933 cm-1, aromatic C-H bending vibration also shown in finger print 998, 829 and 637 cm-1. These vibration regions also indicate the substituted aromatic system. The sharp aromatic C=C stretching vibration Research on biostatic activity of Eusiderin I from Eusideroxylon zwagery against Sclerotium rolfsii had been carried out. The isolated Eusiderin I was a white crystal with melting point in such 99-100 oC. The UV spectra in CHCl3 showed absorbance at  also shown in 1597 and 1508 cm-1. Peak with wave number of 1358-1136 cm-1 was C-O-C groups. The biostatic activity test of Eusiderin I from Bulian wood (Eusideroxylon zwagery) to phatogen fungi of Sclerotium rolfsii showed that with three different concentrations (3, 4 and 5 ppm), Eusiderin I was a potent biofungicide because it had a strong activity in inhibiting the Sclerotium rolfsii growth. The 5 days incubation test result showed that 4 ppm Eusiderin I could inhibit the Sclerotium rolfsii colony growth. The 5 ppm Eusiderin I gave the most effective inhibition precentage because it could inhibit the Sclerotium rolfsii colony growth (= 49.5%).
Respon Pertumbuhan Semai Tanjung (Mimusops elengi Linn) Terhadap Pemberian Pupuk Kandang Ayam
Authors: Puri Suci Ratna , Hamzah Hamzah , Handayani Rajjitha , Rif'atunidaudina Ria , Rumondang Jenny , Armada Galang
Published: January 2025

ABSTRACT
The sufficiency of nutrients in the soil greatly affected the growth and development of plants. The type of plant largely determines its nutritional requirement. Tanjung (Mimusops elengi Linn.) is one of type the forestry plant that has the ability of adapt to air pollution, so that it making it potential to be developed as a protective tree in urban forest development programs. The objective of this research was to determine how the Tanjung seedling growth responds to the dose of chicken manure in the nursery of the Agriculture Faculty, Jambi University. The study used a completely randomized design with a dose of chicken manure as the treatment. The treatments consisted of 5 levels, namely without chicken manure, 500 g/polybag, 750 g/polybag, 1000 g/polybag, and 1250 g/polybag. The research results showed that the dose of chicken manure affected on growth of Tanjung seedlings. The application of 1250 g of chicken manure per polybag had best effect on diameter, number of leaves, shoot dry weight, total dry weight, and root shoot ratio.
 
Keywords: chicken manure, doses, growth, seedling of Mimusops elengi, ultisol soil
 
ABSTRAK
Kecukupan unsur hara dalam tanah sangat mempengaruhi pertumbuhan dan perkembangan suatu tanaman. Kebutuhan akan nutrisi sangat ditentukan oleh jenis tanaman itu sendiri. Tanjung (Mimusops elengi Linn.) merupakan salah satu tanaman kehutanan yang yang memiliki kemampuan adaptasi terhadap polusi udara sehingga berpotensi untuk dikembangkan sebagai pohon pelindung pada program pengembangan hutan kota. Tujuan penelitian ini adalah untuk menentukan dosis pupuk kandang yang optimal untuk pertumbuhan bibit tanjung. Penelitian ini menggunakan rancangan acak lengkap dengan dosis pupuk kandang ayam sebagai perlakuan yang terdiri atas 5 taraf yaitu tanpa pemberian, 500 g/polibag, 750 g/polybag, 1000 g/polybag, and 1250 g/polybag. Hasil penelitian menunjukkan dosis pemberian pupuk kandang ayam berpengaruh terhadap pertumbuhan bibit tanjung. Perlakuan pupuk kandang dengan dosis 1250 g/polybag memberikan respon pertumbuhan terbaik terhadap diameter, jumlah daun, berat berat kering tajuk, berat kering total dan nisbah tajuk akar pada bibit tanjung.
 
Kata kunci: dosis, pertumbuhan, pupuk kandang ayam, semai tanjung, tanah ultisol
Environmental assessment of municipal waste in the city of Orel
Authors:   Orel State Agrarian University named after N. V. Parakhin, Dogadina Marina A. , Pravdyuk Alexander I. ,   Orel State University named after I. S. Turgenev, Krivorotova Elena I. ,   Orel State University named after I. S. Turgenev
Published: January 2025

The article considers the data of studies of the physico-chemical composition of municipal waste in the city of Orel. Taking into account the specifics of wastewater sludge indicators typical for each region, the possibility of recycling wastewater as fertilizer additives for artificial soil is being considered.
CULTIVOS DE COBERTURA DE OTOÑO/INVIERNO. EFECTO SOBRE DISPONIBILIDAD Y DINAMICA DEL AGUA EN EL SUELO.
Authors: Pereira Eduardo de Sá , Galantini Juan Alberto , Amado Telmo Jorge Carneiro
Published: January 2025

Universidade Federal de Santa Maria –
UFSM, Santa Maria (RS) - BRASIL

INTRODUCCIÓN
La mayor participación de cultivos de
verano en la región sub-húmeda pampeana
sur, principalmente soja y girasol, ha dado
lugar a una importante reducción en el
aporte de residuos. Intercalar cultivos
invernales, como CC, es una alternativa
a evaluar para proveer residuos ricos
en carbono y mantener la cobertura de
los suelos. Se reconoce que el consumo
hídrico de estos durante el invierno podría
interferir en la oferta normal de agua para

el cultivo sucesor (Duarte, 2002; Venanzi
et al., 2006, Alvarez et al., 2008; Carfagno
et al., 2008, 2013; Sá Pereira et al, 2024).
Según Fernández et al. (2008), el costo
hídrico de incorporar un CC sería un 50%
menor con respecto a un barbecho para el
cultivo de verano siguiente.
Para evaluar convenientemente la
influencia de los CC sobre la disponibilidad
de agua (costo hídrico en la generación de
biomasa) resulta necesario considerar la
capacidad de almacenaje de agua de los
suelos. Este aspecto es particularmente
importante, ya que define el período
necesario para la recarga del perfil (desde
el secado de los CC hasta el momento
en que el agua es requerida por el cultivo
siguiente). Además, otro de los factores que
incide en la disponibilidad es la fecha de
siembra del cultivo sucesor: para siembras
de maíz (octubre) los CC deberían finalizar
la extracción de agua antes que para
siembras de soja (noviembre).
Processional cross from medieval Svrljig: Origins and role in sacred rituals
Authors: Petrovic Nemanja
Published: January 2025

Research on liturgical objects, particularly processional crosses, is of
special importance. It has shown that their purpose and function originated
from the cult of the Holy Cross, as well as from the experience of
processions and ritual circumambulations aimed at expanding ?new? spaces and
forming a Christian sacred topography. Processional crosses, along with
icons and other liturgical objects, constitute an essential part of Orthodox
liturgical practice. This paper examines the role of one such cross
discovered in the 1920s near the medieval town of Svrljig.
Reconsidering the 1095 novella of Alexios I Komenenos: A testimony to the Byzantinization of the Slavic population
Authors: Ilic Tamara
Published: January 2025

The Novella issued by the Byzantine emperor Alexios I Komnenos in 1095
regulates the process of proving freedom for persons descended from
?Bulgarians and the like? and the introduction of mandatory religious
marriage, which scholarship tends to interpret as the full penetration of
the Christian notion of grace into these spheres of life. The text of this
Novella, abridged, slightly revised, and in Old Serbian translation,
reappears in the Nomokanon of St. Sava and some subsequent Old Russian
Nomokanons. This paper employs the historical method and linguistic analysis
of a range of sources to explore the role of this law in the process of the
Byzantinization of the Slavic population.
“Serbian land” in the Tărnovо inscription of John Asen II in the light of the political and geographical terminology of the time
Authors: Komatina Ivana , Komatina Predrag
Published: January 2025

This study examines the notion of friendship depicted in the epistolary
corpus of Euthymios Malakes who served as bishop of Neai Patrai during the
second half of the twelfth century. His letters do not contain solely
references to everyday problems, such as the difficulties that his diocesan
floc had to encounter because of the hatred, the rapacity and the insatiable
greed of state tax collectors, but they are also considered as vehicles for
emotions towards his relationship with his friends and peers, either clerics
or laymen. Therefore, the aim of the present article is to highlight
Malakes? view regarding the notion of friend and to shed light on how his
theory on friendship was influenced by ancient Greek and Christian writings.
“O περιποθητοσ θειοσ τησ βασιλειασ μου” – Theodore Synadenos and his relatives (A contribution to the genealogy and prosopography of the Nemanjic dynasty and the Palaiologoi)
Authors: Hekic Benjamin
Published: January 2025

In this paper, we re-examine family relations between the rulers of Nemanjic
Serbia, the Bulgarian Tsardom and Byzantium, focusing on the prominent
Byzantine magnate Theodore Synadenos, whom Tsar Stefan Dusan and Emperor
Andronikos III Palaiologos in their charters both call ??????? (uncle) and
whom one narrative source also describes as an uncle of the Bulgarian tsar
Ivan Alexander Asen. Although there was real consanguinity between Dusan and
Synadenos, scholars tended to interpret the fact that Dusan calls Synadenos
his uncle as a reflection of Dusan?s pretensions to ideal kinship with the
Byzantine imperial family. We propose to disprove this view and show that in
every instance in which Dusan (or a member of his family) and the members of
the Palaiologos dynasty refer to each other as relatives, blood or marital
kinship was indeed involved. Lastly, we attempt to answer the question of
kinship ties between Theodore Synadenos and the Bulgarian tsar Ivan
Alexander, i.e. to reconstruct how they were related.
N.P. Kondakov and the Kondakov Institute for Byzantology and Archeology in Belgrade (1938-1941)
Authors: Milovanovic Milan
Published: January 2025

The knowledge in Belgrade about the work of the Kondakov Institute for
Byzantology and Archeology has been reconstructed for the most part based on
personal correspondence that the members of the Institute exchanged during
their stays in Yugoslavia and Czechoslovakia. In order to understand the
activity of the first academic institution in this region for studying
Byzantine history and culture, the paper will first provide a brief history
of the development of the Kondakov Seminar/Institute in Prague, focusing on
analyzing the main reasons and influences that led to its establishment. The
paper pays particular attention to the period when the seminar moved from
Prague to Belgrade due to the difficult political and economic situation.
Much of the scholarly activity of the seminar at its new address can
reconstructed from the unpublished administrative material in public
archives in Serbia. Starting from this body of evidence, one of the goals of
this paper is to provide more meaningful data on the history of the Kondakov
Institute in Belgrade based on new written sources.
The impact of mobilization training time during the first postoperative week on the length of hospital stay in postoperative patients admitted to an intensive care unit
Authors: Ozaki Yusuke , Kono Yuji , Shinohara Ayato , Nakamura Tomoyuki , Ishihara Takuma , Nishida Osamu , Otaka Yohei
Published: January 2025

Objective: To determine the impact of mobilization training time during the first postoperative week on the length of hospital stay for postoperative patients admitted to an intensive care unit.
Design: A retrospective cohort study.
Patients: Consecutive patients who underwent elective surgery and stayed in the intensive care unit of a university hospital for more than 48 h between July 2017 and August 2020 were enrolled.
Methods: The total duration of mobilization training during the first postoperative week and clinical variables, including demographic information, were collected from medical records. Multivariable regression analysis was used to investigate the impact of mobilization training time on the length of hospital stay, adjusting for potentially confounding variables.
Results: In total, 773 patients (504 males; median age, 70 years) were enrolled. Multivariable regression analysis showed that an increase in mobilization training time during the first postoperative week was associated with a shorter length of hospital stay (β = –0.067, 95% confidence interval: –0.120, –0.017, p = 0.010), with each 1-h increase in training time associated with a 4.02-day reduction in the length of hospital stay.
Conclusion: Increased mobilization training during the first postoperative week significantly reduced the length of hospital stay in postoperative patients.
Management of high-flow arteriovenous access
Authors: Park Hoon Suk , Shin Seok Joon
Published: January 2025

An arteriovenous fistula or graft is essential for hemodialysis (HD). It involves connecting a high-resistance artery to a low-resistance vein, which increases cardiac output (CO). In the early days of HD, patients with end-stage kidney disease (ESKD) were typically younger, and their HD access was located in the distal forearm. However, in the modern era, ESKD patients are often the elderly, with many being the very elderly (over 80 years old). These elderly patients often have poor vessel quality, making distal forearm access unsuitable. As a result, upper arm access, which is more prone to high-flow access, is commonly used. The cardiac status of these modern elderly ESKD patients is vulnerable to high-flow access. High-flow HD access can lead to high-output cardiac failure in ESKD patients. Initial evaluation for high-flow access involves measuring the flow volume using Doppler ultrasound. If the HD access flow volume exceeds 2,000 mL/min, further assessments, including CO and cardiopulmonary recirculation ratio caused by the HD access, should be strongly considered. Treatment for high-flow access involves reducing the flow. There are several surgical and endovascular methods for flow reduction, such as aneurysmorrhaphy, short segment small-diameter graft interposition at the inflow area of the HD access, and banding. Patients with high-flow access are generally asymptomatic. Therefore, nephrologists as primary care physicians for HD patients should provide detailed explanations to patients with high-flow access and high-output cardiac failure and ensure that they understand the prognosis of these conditions. Nephrologists need increased attention to high-flow HD access.
The Influence of The School Principal's Leadership Style and Empowerment Through Motivation on Teacher Participation in The Sekolah Penggerak Program
Authors: Iswahyudi  , Harsono  , Suyatmini
Published: January 2025

One of the efforts to improve the quality of 21st-century learning is the Driving School Program. There are several obstacles in running the program, including low teacher participation. Teacher participation can be influenced by the principal's leadership style, empowerment, and teacher motivation. This study aims to analyze the influence of the principal's leadership style and empowerment through motivation on teacher participation in the driving school program. This type of research is correlational with a quantitative approach. The subjects of this study were principals and teachers of public high schools undergoing the driving school program in Boyolali.  Data were collected using a questionnaire through a Google form supported by observation and documentation. Data were analyzed with PLS (Partial Least Square) through SmartPLS software. The data processing results show a significant influence between the Principal's Leadership Style through the intervening variable of Teacher Motivation on Participation. There is a substantial influence between empowerment through motivation and Teacher Participation. The results of the data analysis show that the hypothesis is accepted. The Teacher Motivation variable has a medium-high influence in mediating the Principal Leadership Style variable on the teacher Participation variable with a statistical value of upsilon (v) mediation effect of 0.0137. Teacher Motivation has a medium influence in mediating the Empowerment variable on Teacher Participation.