bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of service quality against visitor loyalty through visitor satisfaction
Authors: Hidayat Firman , Asnawi Nur
Published: September 2019

The success of a government intention is to the satisfaction of the community about the service provided by the intense, the quality of service, satisfaction, and validity are important aspects that must be considered so that government institutions can be considered successful in serving the community. The purpose of this study was to determine the direct effect of service quality on visitor satisfaction and visitor loyalty and the influence of visitor satisfaction on visitor loyalty and the influence of service quality on visitor loyalty through visitor satisfaction. From this background this research was carried out with the title "The Effect of Service Quality on Visitor Loyalty Through Visitor Satisfaction. (Study at Banyuwangi Public Service Mall, East Java) ".

This study uses a quantitative approach, the sample in this study was 181 respondents. Data collection with questionnaires, interviews, and documentation. The data analysis technique used in this study is Partial Least Square (PLS).

From the results of the study showed that there is a direct effect of service quality on visitor satisfaction and visitor loyalty, there is a direct influence of visitor satisfaction on visitor loyalty and there is an indirect effect of service quality on visitor loyalty through visitor satisfaction at the Banyuwangi public service mall.

Keywords: Service Quality, Visitor Satisfaction, Visitor Loyalty
Designing self helps groups’s communication strategy to explore women expectation in small enterprises
Authors: Sumiati Sumiati , Rosita Nadiyah Hirfiyana , Ayuni Risca Fitri , Attamimi Dian
Published: September 2019

Women empowerment is becoming a current issue in sustainable development goals. Every developing country trying to promote the women empowerment issues in every sector. In Indonesia, this issues actively risen by PKK. PKK is the simplest form of self helps group organizations that can be found in almost whole areas of Indonesia. This organization is driven by women members, so they can interact with each other for self-development and group development. In order for these development efforts to be effective, identifying the expectations and needs of the community are very principal before defining the right communication strategy to reach the community. Based on focus group discussion that has been done with PKK members of Desa Jambu as a group of self helps group in developing small and medium enterprises in Desa Jambu, Sumenep there are three expectations related to PKK function that is delivered as learning facilities, cooperation medium, and production unit. To meet those expectations, communication strategy through counseling and training can be chosen as primary strategy.
HYGIENIC PROBLEMS DURING THE OPERATION OF ENTERPRISES FOR THE PRODUCTION OF ENERGY-POWERFUL MATERIALS
Authors: Krylova N. V. , Britanov N. G , Klauchek V. V. , Sazonova N. G , Tobol'skaya-Pospelova M. M , Gerbovnik-Busova O. V.
Published: September 2019

During the operation of enterprises for the production of energy-intensive materials, hazardous chemicals can be released into the production and environment, where they can have a negative impact on the health of the personnel of the enterprise and residents of nearby communities. Nitroglycerin, ammonium perchlorate, aluminum and trinitrotoluene make the most significant contribution to the pollution of the working environment. In the atmospheric air of the territory adjacent to the object under study, in different years, excess of the maximum single concentrations of ammonium perchlorate and aluminum oxide were recorded.
NEURORECEPTOROLOGICAL EFFECTS OF ANTIMIGRAINE AGENT 9-DIETHYL-2- (4-METHOXYPHENYL)IMIDAZO[1,2-A] BENZIMIDAZOL
Authors: Agatsarskaya Ya. V , Yakovlev D. S , Maltsev D. S , Semenova Yu. V. , Salikhov D. A , Sultanova K. T. , Anisimova V. A
Published: September 2019

The 5-НТ2А antagonistic, M-cholinergic, histaminergic and GABA-ergic properties of 9-diethylaminoethyl-2-(4-methoxyphenyl) imidazo [1,2-] benzimidazole dihydrochloride - RU-31 compounds with antimigraine properties were studied. Moderate M-anticholinergic and GABA mimetic action and no effect on histaminergic system were shown for RU-31 compound in vivo models in vitro.
AGE AND GENDER PECULIARITIES OF HEART RATE VARIABILITY IN HEALTHY ADOLESCENTS
Authors: Sheveleva A. M
Published: September 2019

Introduction. The aim of the study was to find out gender and age peculiarities of the circadian rhythm of heart rate variability in healthy adolescents. Materials and methods: holter-ECG (spectral and temporal parameters of heart rate variability). 354 healthy adolescents were recruited to participate in this study. Results: adolescent girls have higher impact of parasympathetic nervous system to the heart rate modulation in comparison with boys. Relative power of the high-frequency band increased at night in girls and didn't significantly change in boys. Relative power of the low-frequency band decreased at night both in girls and in boys. Conclusion. The activity of divisions of autonomic nervous system in adolescents has circadian profile and differ in children of different sex and age.
POTENTIAL OF ONYXCEPH3™ COMPUTER SOFTWARE AT THE STAGE OF ORTHODONTIC TREATMENT DIAGNOSIS AND PLANNING
Authors: Klimova N. N , Botasheva A. R , Khvan A. A
Published: September 2019

In this study we made comparison of the accuracy of linear and angular parameters according to the data of lateral cephalometry got with the computer software (OnyxCeph3TM version 3.2.100) and manual method at the stage of orthodontic treatment diagnosis and planning and also the possibility of usage of OnyxCeph3TM software was shown for purposes of easing and fastening oral and maxillofacial pathology diagnosis when planning orthodontic treatment.
BISPHOSPHONATE-RELATED OSTEONECROSIS OF THE JAW
Authors: Fomichev E. V. , Kirpichnikov M. V. , Yarygina E. N , Podolsky V. V. , Nesterov A. A
Published: September 2019

Bisphosphonates (BPs) are a class of drug used to treat osteoporosis and malignant bone metastasis. BPs show high binding capacity to the bone matrix, especially in sites of active bone metabolism. According to modern data, bisphosphonate osteonecrosis of the jaws (BPONJ) is a complication of antiresorptive therapy, characterized by death and exposure of the bone area, which persists for more than 8 weeks, with subsequent progression of the process, provided there is no radiation therapy on the head area in history. BRONJ can adversely affect quality of life, as it may produce significant morbidity. The purpose of this article is to offer a perspective on how dentists should manage patients on BPs, and to present diagnostic aids and treatment s strategies to the condition.
CLINICAL TRIAL OF NATURAL COMBINATION THERAPIES IN THE TREATMENT OF CHRONIC GENERALIZED PERIODONTITIS OF MODERATE SEVERITY
Authors: Sharonova N. A , Temkin E. S , Poroshin A. V
Published: September 2019

Inflammatory periodontal diseases are widespread all over the world, occupying a leading place among pathologies leading to loss of teeth and disruption of the body as a whole. In Russia, about 98 % of the population is affected by the disease. The connection of periopathology with somatic diseases, the absence of a long lasting effect after treatment, frequent exacerbations, the appearance of allergic reactions to the drugs used, justified the search for new drugs of natural origin that have a minimal toxic effect, expressed by pharmacological properties, locally penetrating into the deeper layers of tissues. The drug of choice was a combination: a magnesium-containing medicinal preparation Polycatan and an aquacomplex of glycerol solvate of titanium Tizol. As a result of the influence of the mineral-containing combination, the inflammatory process was more quickly stopped, the vascular bed normalized, the clinical and index indicators stabilized, and the patients improved their overall treatment of the periodontal disease.
ANTIGLYCATION AND DPP-4 INGIBITION ACTIVITY OF NOVEL AZOLEAZINE-DERIVED COMPOUNDS
Authors: Sokolova E. V , Hohlacheva E. A , SHamshina D. D , Batychyok A. E , Radaev P. A , Prokof'eva N. A , Litvinov R. A , Babkov D. A , Savateev K. V. , Fedotov V. V.
Published: September 2019

As a result of in vitro screening studies to search for the possible antidiabetic activity of a number of azoloazine derivatives, it was found that the compounds are capable of moderate inhibition of dipeptidylpeptidase-4 (DPP-4), inhibiting the enzyme activity by an average of 60 % at a concentration of 100 цМ, which is inferior actions of the reference drug vildagliptin (more than 99 % of the suppression of the activity of DPP-4 at the same concentration). The compounds are also able to significantly slow down glycation of bovine serum albumin (BSA) (the series leader - compound 1c suppresses the glycation reaction of BSA by 74 % at a concentration of 1 mM, compared to 58 % inhibition for the reference compound aminoguanidine). It was not possible to establish the ability of compounds to bind (chelate) Cu2+ in the ascorbic acid autooxidation test, except for compound 1k (it slowed down the reaction by 49 % at a concentration of 40 цМ, which is comparable in activity to the reference drug pioglitazone and is slightly more active than lipoic acid). The restriction for establishing the copper-binding activity of other members of the series is due to the high light absorption at the working wavelength of 265 nm and is not a criterion for excluding chelating properties. The results allow us to conclude that the class of compounds is a promising basis for the further development of tools with anti-glycating activity based on the structures of the representatives of the series.
CEREBRAL CIRCULATION OF RUSSIAN AND FOREIGN STUDENTS IN VARIOUS FORMS OF MENTAL ACTIVITY
Authors: Mandrikov V. B , Sevriukova G. A , Isupov I. B , Likhodeeva V. A
Published: September 2019

During the classroom, intermediate control of knowledge and during the exam studies of the dynamics of pulse blood filling of the brain, the tone of the resistive arteries and conditions of cerebral venous outflow of blood of students of higher educational institutions. The majority of persons showed negative changes in the tone of the resistive arteries of the brain and difficulty in venous outflow of blood during various forms of knowledge control. Changes in cerebral blood flow are most significant during the exam. In the period of exam develops situational tachycardia, sympathetic tone. This negatively affects the tone of the resistive arteries of the brain and venous blood flow. The development of situational sympathicotonia must be considered when follow-up surveys of students.
Цифровизация процессов обслуживания в библиотеках – это уже реальность
Authors: Neshcheret M. Yu.
Published: September 2019

The article considers theoretical issues of digitalization in libraries, characterizes modern forms and methods of providing library and information services, ways of communication between libraries and users. It reveals qualitatively new opportunities of library and information service due to spreading digital technologies and robotics in libraries. Cases of successful implementation of library and information services digitization projects demonstrate the library readiness to move to a new level of development. The author concludes that despite the fact that digitalization significantly increases services efficiency, effects positively on their quality and, consequently, attracts new users to libraries, library information services also include processes that are impossible without human participation with qualities such as the ability to anticipation, emotional experience, intuitive forecasting. Therefore, it is necessary to be aware of the boundaries and professional needs when using digital technologies in library and information services.
Evidence that Homeostatic Sleep Regulation Depends on Ambient Illuminance Levels
Authors: Cajochen Christian , Reichert Carolin , Maire Micheline , Schlangen Luc J M , Schmidt Christina , Viola Antoine U , Gabel Virginie
Published: September 2019

We examined whether the ambient illuminance during extended wakefulness modulates the homeostatic increase in human deep sleep [i.e. slow wave sleep (SWS) and electroencephalographic (EEG) slow-wave activity (SWA)] in healthy young and older volunteers. Thirty-eight young and older participants underwent 40 hours of extended wakefulness [i.e. sleep deprivation (SD)] once under dim light (DL: 8 lux, 2800K), and once under either white light (WL: 250 lux, 2800K) or blue-enriched white light (BL: 250 lux, 9000K) exposure. Subjective sleepiness was assessed hourly and polysomnography was quantified during the baseline night prior to the 40-h SD and during the subsequent recovery night. Both the young and older participants responded with a higher homeostatic sleep response to 40-h SD after WL and BL than after DL. This was indexed by a significantly faster intra-night accumulation of SWS and a significantly higher response in relative EEG SWA during the recovery night after WL and BL than after DL for both age groups. No significant differences were observed between the WL and BL condition for these two particular SWS and SWA measures. Subjective sleepiness ratings during the 40-h SD were significantly reduced under both WL and BL compared to DL, but were not significantly associated with markers of sleep homeostasis in both age groups. Our data indicate that not only the duration of prior wakefulness, but also the experienced illuminance during wakefulness affects homeostatic sleep regulation in humans. Thus, working extended hours under low illuminance may negatively impact subsequent sleep intensity in humans.
Shannon Entropy of Epithelium and Five-Fold Morphology: A Fundamental Model to Explain Geometrical Organizations as a Source of Information in Biological Systems
Authors: López-Sauceda Juan , Carrillo Gonzalez Jose Gerardo , Ortega Laurel Carlos , von Bülow Philipp , Mejia Carmen
Published: September 2019

Based on a measuring system to determine levels of spatial organization in 2D polygons (homogeneous or heterogeneous partition of defined areas) lying on principles of regularity, we propose the entropy term linked to the concept of “information”, from the “information theory field”, in order to obtain an information measurement regarding a quantity of or amount of information in the architecture of complex 2D biological organizations. The term “quantity” does not refer to the amount of data (size), but to the probability of a geometrical basic pattern within a set of possible statistical configurations regarding levels of homogeneity and heterogeneity. It is this notion of information that is important in information theory, and measures of information in units of bits, what we propose to use for measuring quantities of organization in the architecture of complex geometrical systems. Two complex systems are tested, biological and non biological in order to obtain experimental results, which are verified with the evaluation criteria “entropy”. Experimental results show that the lowest levels of information and entropy, in addition with low rates of heterogeneity and high rates of homogeneity are particular features of geometrical organizations in biological systems.
Intravenous Immunoglobulin for Treating Bacterial Infections: One More Mechanism of Action
Authors: Sawa Teiji , Kinoshita Mao , Inoue Keita , Ohara Junya , Moriyama Kiyoshi
Published: September 2019

The mechanisms underlying the effects of γ-globulin therapy for bacterial infections are thought to involve bacterial cell lysis via complement activation, phagocytosis via bacterial opsonization, toxin neutralization, and antibody-dependent cell-mediated cytotoxicity. Nevertheless, recent advances in the study of pathogenicity in gram-negative bacteria have raised the possibility of an association between γ-globulin and bacterial toxin secretion. Over time, new toxin secretion systems like the type III secretion system have been discovered in many pathogenic gram-negative bacteria. With this system, the bacterial toxins are directly injected into the cytoplasm of the target cell through a special secretory apparatus without any exposure to the extracellular environment and, therefore, with no opportunity for antibodies to neutralize the toxin. However, because antibodies against the V-antigen, which is located on the needle-shaped tip of the bacterial secretion apparatus, can inhibit toxin translocation, this raises the hope that the toxin might be susceptible to antibody targeting. Because multi-drug resistant bacteria are now prevalent, inhibiting this secretion mechanism is attractive as an alternative or adjunctive therapy against lethal bacterial infections. Thus, it would not be unreasonable to define the blocking effect of anti-V-antigen antibodies as the fifth mechanism for immunoglobulin action against bacterial infections.
Osmotic Fragility in Essential Hypertension Revisited: A Correlation with Iron Status and Lipid Profile
Authors: Al-Hakeim Hussein Kadhem , Alhillawi Zainab Hussein , Al-Ani Sahatha Raoof
Published: September 2019

Background: Essential hypertension is a major public health associated with increase pressure on the vascular walls and red blood cells (RBCs). In the present work, osmotic fragility (OF) of RBCs was reexamined in the means of its correlation with two risk factor; iron status and lipid profile. Experimental: OF, iron status parameters, and lipid profile components were measured in 60 patients and compared with the results of 30 controls. Results: The results showed a significant increase in all iron indices of hypertensive patients in comparing with healthy control group except TIBC, UIBC, and transferrin concentrations, which decrease in these patients in comparing with control group. Serum TGs, total cholesterol, VLDLc, and LDLc were increased while there is no significant in serum HDLc in patients to comparing with control group. There is no significant change in OF between patients and controls where p=0.173. The iron status parameters and lipid profile components were dependent on sex and smoking state. Hemoglobin and PCV were correlated significantly with total cholesterol and LDLc. Transferrin saturation showed a positive correlation with cholesterol, LDLc, and TGs, but negatively correlated with HDLc. No significant correlation between all the measured parameters and OF in HT patients. There is a significant correlation between serum ferritin and systolic BP and between Hb and systolic BP. Conclusion: No significant effect on the OF in HT patients. HT patients have elevated level of iron parameters in comparing with controls. OD has no correlation with iron status parameters or with lipid profile components.
Stimulation of Human Osteoblast Differentiation in Magneto-Mechanically Actuated Ferromagnetic Fibre Networks
Authors: Katarivas Levy Galit , Birch Mark A. , Brooks Roger A. , Neelakantan Suresh , Markaki Athina E.
Published: September 2019

There is currently an interest in “active” implantable biomedical devices that include mechanical stimulation as an integral part of their design. This paper reports the experimental use of a porous scaffold made of interconnected networks of slender ferromagnetic ﬁbres that can be actuated in vivo by an external magnetic ﬁeld applying strains to in-growing cells. Such scaffolds have been previously characterized in terms of their mechanical and cellular responses. In this study, it is shown that the shape changes induced in the scaffolds can be used to promote osteogenesis in vitro. In particular, immunofluorescence, gene and protein analyses reveal that the actuated networks exhibit higher mineralization and extracellular matrix production, and express higher levels of osteocalcin, alkaline phosphatase, collagen type 1a1, runt-related transcription factor 2 and bone morphogenetic protein 2 than the static controls at the 3-week time point. The results suggest that the cells filling the inter-fibre spaces are able to sense and react to the magneto-mechanically induced strains facilitating osteogenic differentiation and maturation. This work provides evidence in support of using this approach to stimulate bone ingrowth around a device implanted in bone and can pave the way for further applications in bone tissue engineering.
The Cooling Effect of Large-Scale Urban Parks on Surrounding Area Thermal Comfort
Authors: Aram Farshid , Solgi Ebrahim , Higueras Garcia Ester , Mosavi Amir , R. Varkonyi-Koczy Annamaria
Published: September 2019

This empirical study investigates large urban park cooling effects on the thermal comfort of occupants in the vicinity of the main central park, located in Madrid, Spain. Data were gathered during hot summer days, using mobile observations and a questionnaire. The results showed that the cooling effect of this urban park of 140 ha area at a distance of 150 m is able to reduce temperature by an average of 0.63°C and 1.28°C for distances of 380 m and of 665 meters from the park. Moreover, the degree of the Physiological Equivalent Temperature (PET) index at a distance of 150 meters from the park is on average 2°C PET and 2.3°C PET less compared to distances of 380 m and 665 m, respectively. Considering distance from the park, the correlation between occupant Perceived Thermal Comfort (PTC) and PET is inverse. That is, augmenting the distance from park increases PET, while the extent of PTC reduces accordingly. The correlation between these two factors at the nearest and furthest distances from the park is meaningful (P-value <0/05). The results also showed that large-scale urban parks generally play a significant part in creating a cognitive state of high-perceived thermal comfort spaces for residents.
PEMBERDAYAAN USAHA KERAJINAN TEMBAGA MELALUI PENGEMBANGAN DESAIN DAN PELATIHAN PEMBUKUAN
Authors: Mulyanto Mulyanto , Wardani Dewi Kusuma
Published: September 2019

Tujuan kegiatan pengabdian ini adalah pemberdayaan usaha kecil
kerajinan tembaga melalui pengembangan desain produk dan
pembenahan pembukuan. Kegiatan ini dilaksanakan di usaha Mashuri
dan usaha Rofiq di Desa Tumang, Kecamatan Cempogo, Kabupaten
Boyolali, Propinsi Jawa Tengah melalui pendekatan tindakan partisipatif,
pendidikan orang dewasa, pengembangan kreatifitas, diskusi terfokus,
dan belajar mandiri. Langkah-langkah tindakan disesuaikan dengan teori
pengembangan desain yaitu diawali dengan melakukan analisis
kebutuhan pasar, penyusunan konsep dan perencanaan produksi, proses
kreatif, uji produk, proses produksi, dan diakhiri dengan evaluasi. Hasil
kegiatan ini yaitu para pengrajin tembaga mitra telah mampu
memproduksi berbagai produk dengan menggunakan bahan baku plat
tembaga dan kuningan baik produk yang berbentuk tunggal maupun
produk dalam bentuk komponen, dan mampu memproduksi produk
dengan teknik tempa, teknik ukir, teknik plat, dan teknik anyaman. Selain
itu, pengrajin juga mampu membuat pembukuan sehingga mengetahui
kinerja usahanya. Luaran kegiatan berupa produk-produk baru yang
sebelumnya belum pernah dikerjakan yang terdiri atas tiga aspek, yaitu
(1) katalog berupa berbagai tekstur produk dan berbagai jenis
finishingnya sebagai sampel untuk media promosi secara nyata, (2)
produk-produk kerajinan tembaga secara utuh, dan (3) produk kerajinan
tembaga yang berupa komponen. Produk tembaga yang bersifat utuh
meliputi berbagai lampu gantung dan lampu taman dengan berbagai
teknik finishingnya. Produk tembaga yang bersifat komponen yaitu
berupa komponen atap kubah masjid yang berbentuk belah ketupat
berukir dengan berbagai ukuran dan kaligrafi komponen pintu masjid.
SUBSTITUSI IPTEKS PEMBESARAN LELE TEBAR PADAT
Authors: I.F. Nurcahyo I.F. Nurcahyo , Hidayat Yuniawan , Suryanti Venty , Handayani Desi Suci , Lestari Witri Wahyu , Pramono Edi
Published: September 2019

Petani pembesaran lele banyak yang mengeluh gagal dalam usaha
pembesaran lele. Kegagalan tersebut disebabkan oleh penggunaan pakan
dan kolam yang tidak efisien serta harga pakan mahal. Tujuan kegiatan
pengabdian masyarakat ini memberikan wawasan tentang metode baru
dalam usaha pembesaran lele yang menguntungkan. Mitra pengabdian
kegiatan ini yaitu kelompok pembesaran lele Sungut Emas di Boyolali dan
petani-petani pembesaran lele disekitarnya. Metode pengabdian
dilakukan dengan metode substitusi ipteks secara teori, praktek lapangan,
dan pendampingan. Substitusi ipteks secara teori meliputi penjelasan
tentang pembesaran lele tebar padat dan aplikasi enzim dalam efisiensi
pakan. Materi praktek lapangan meliputi cara persiapan air, cara
pengelolaan air, cara menangani penyakit dan cara memberi pakan.
Simpulan, substitusi ipteks pembesaran lele tebar padat mampu
menyelesaikan masalah yang dihadapi petani pembesaran lele tebar padat
sehingga keuntungan usaha meningkat.
PELATIHAN PEMBUATAN CENDERAMATA SEBAGAI PRODUK WISATA BAGI MASYARAKAT PEDAGANG ACUNG DI DESA BATUR TENGAH
Authors: Widiastini Ni Made Ary , Andiani Nyoman Dini , Agustini Karta Ni Luh Putu
Published: September 2019

The purpose of this devotion is to train some of people in Batur
Tengah Village who work as merchants to make tourism products
independently. During this tourism products are sold in the Kintamani
Tourism Area such as clothing, sculpture or knick knacks such as key
chains are supplied from other places, both other areas that are still in the
province of Bali and outside Bali. The phenomenon is actually not good
for the sustainability of the efforts that are cultivated by some people in
the village of Batur Tengah. In addition to creating dependency, they are
also used by suppliers as marketers to sell their products as well as
understand the needs of tourists who visit Bali, especially to Kintamani
tourism area. Based on this phenomenon, then on this occasion, the
devotion done by trained on some souvenir vendor to create a souvenir
merchandise products independently, such as key chains and hangers that
can be installed in the car. It is expected that through this training which
held on in open space so that tourists can see it, then interested to buy, can
influence the people of Batur Tengah Village who work as souvenir
vendor to create tourism product independently that the result can be felt
better economically.
Key Words: Devotion, Create, Souvenir, Tourism Product
PEMBERDAYAAN MASYARAKAT MELALUI IbM PELATIHAN OLAHAN LIMBAH TAHU DI DESA DRONO NGAWEN KLATEN
Authors: Rohmansyah Nur Azis , Nurdyansyah Fafa , Prastiwi Bertika Kusuma
Published: September 2019

This community empowerment activity through science and
technology program for the community aims to increase the knowledge of
the community at Drono village, Ngawen Klaten regency of Central Java.,
especially the women in processing and utilizing solid waste in making
nuggets, tempeh, and milk which is economically valuable and
encouraging people to create new business to increase the income of
surrounding communities. The methods used are socialization and
counseling, waste utilization training, production management and
financial administration, program discussions and evaluation. The
activity was held at the residence of one of Drono Ngawen villagers with
25 women. During the activity all participants were very enthusiastic, all
participants were also given material about the utilization of tofu
production waste to be processed into economic value products. Each
participant is equipped with guidance about management of online
marketing and finance, also coaching about establishment new efforts to
improve skills and knowledge.
Keywords: tofu waste, training, management, bussiness, IbM
“OMAH TELO”: PENGEMBANGAN PRODUK BERBASIS UBI JALAR DI PROGRAM STUDI ILMU DAN TEKNOLOGI PANGAN
Authors: Siswanti Siswanti , Anandito R. Baskara , Yudhistira Bara
Published: September 2019

Tracer study which has been done by Department of Food Science and
Technology showed that only 62,5% of graduates have related job to the major, while
from 62,5% that have, only 10% become businessman/entrepreneur. This matter
necessarily become a shared duty of the study program to escalate student
entrepreneurial spirit since early on. Step that had been taken by the study program in
order to evoke student entrepreneurial spirit has not given maximum result because
students could not apply their sciene of entrepreneurship in a business unit practice
directly. Therefore, Department of Food Science and Technology is commited to evoke
and escalate student entrepreneurial spirit by forming a production unit named “Omah
Telo”. This program is directed to obtain reveneu generating for the research group in
particular, Department of Food Science and Technology in general and also build
technopreneurship sprit in HIMAGHITA. In its first year, this program has been
successfully build up a productive business unit “Omah Telo” with chips and sweet
potato flour as the main products, also tela-tela, sweet potato stick, ice cream and
schotel as the additional products. The entrepreneurship talkshow, food industry
management, and also marketing techniques have established the technopreneurship
spirit of the students. PIRT permission and online marketing could increase the product
marketing of IbPTK production.
Keyword: omah telo, technopreneurship, sweet potato
APLIKASI PLTS ON GRID PADA USAHA PEMBESARAN LELE
Authors: Nurosyid Fahru , Supriyanto Agus , Suryana Risa , Iriani Yofentina
Published: September 2019

Application of on-grid PLTS on the effort of catfish enlargement aims to reduce the cost for the fulfillment of electrical energy, increase knowledge and train the skills to assemble PLTS on grid. Farmers catfish use electrical energy to power the water pump. PLTS on grid enables saving on electricity costs. The use of on-grid PLTS does not require an electric storage battery. The overproduction of electricity from PLTS allows it to be sold to PLN. If there is a shortage of electricity, then electricity is purchased from PLN. Public knowledge about PLTS can be introduced in theory and practice of PLTS installation scale 2000 WP (watt peak). The use of 2000 WP can produce 9.2 KWH / day in sunny conditions.e
THE SPRING VARIATION IN TWO DIMENSIONAL MODELING OF RED BLOOD CELL DEFORMABILITY BASED ON GRANULAR
Authors: Yasifa Ismi , Viridi Sparisoma
Published: September 2019

The red blood cell membrane has a complex structure and high deformability. Simulation of that complex red blood cell membrane can simpler use granular-based modeling. Red blood cell is modeled consisting of 50 granular particles connected by springs. An i-particle is connected with two of its first nearest particles which are i+1-particle and i-1-particle and with two of its second nearest particles which are i+2-particle and i-2-particle. Each particle has a spring force and forces from internal hydrostatic pressure. Spring force is a product of the spring constant and change of spring length of two particles. Meanwhile, forces of internal hydrostatic pressure is a product of particle diameter and the difference in the outside and inside pressure of red blood cell membrane. In this research, there is variation in spring length and spring constant that can model deformability of three shapes of red blood cell; those are biconcave, ellipse, and circle. This variation in spring length and spring constant for every cell shape in this modeling can also use for other initial cell shapes, which shows that initial cell shapes deform into shape according to variation used.
Alterations in the chondrocyte surfaceome in response to pro-inflammatory cytokines
Authors: Jeremiasse Bernadette , Matta Csaba , Fellows Christopher R. , Boocock David J. , Smith Julia R. , Liddell Susan , Lafeber Floris , Spil Willem E. van , Mobasheri Ali
Published: September 2019

Background: Chondrocytes are exposed to an inflammatory micro-environment in the extracellular matrix (ECM) of articular cartilage in joint diseases such as osteoarthritis (OA) and rheumatoid arthritis (RA). In OA, degenerative changes and low-grade inflammation within the joint transform the behaviour and metabolism of chondrocytes, disturb the balance between ECM synthesis and degradation, and alter the osmolality and ionic composition of the micro-environment. We hypothesize that chondrocytes adjust their physiology to the inflammatory microenvironment by modulating the expression of cell surface proteins, collectively referred to as the ‘surfaceome’. Therefore, the aim of this study was to characterize the surfaceome of primary equine chondrocytes isolated from healthy joints following exposure to the pro-inflammatory cytokines interleukin-1-beta (IL-1β) and tumour necrosis factor-alpha (TNF-α). Methods: We employed combined methodology that we recently developed for investigating the surfaceome in stem cells. Membrane proteins were isolated using an aminooxy-biotinylation technique and analysed by mass spectrometry using high throughput shotgun proteomics. Results: Amongst the 431 unique cell surface proteins identified, a high percentage of low-abundance proteins, such as ion channels, receptors and transporter molecules were detected. Data are available via ProteomeXchange with identifier PXD014773. A high number of proteins exhibited different levels of expression following chondrocyte stimulation with pro-inflammatory cytokines.LPR-1, thrombospondin, VDAC1-2 and annexin A1 were considered to be of special interest and were analysed further and validated by western blotting. Conclusions: Our results provide, for the first time, a repository for proteomic data on differentially expressed low-abundance membrane proteins on the surface of chondrocytes in response to pro-inflammatory stimuli.
A novel PCR method targeting staphostatin genes differentiates Staphylococcus aureus from Staphylococcus epidermidis in clinical isolates and nasal microbiome samples
Authors: Ghattas Marina Zoheir , ElRakaiby Marwa Tarek , Aziz Ramy Karam , Zedan Hamdallah H.
Published: September 2019

Staphylococcus aureus is a pathogen associated with community-acquired and healthcare-associated infections, and is known for rapid acquisition of resistance to multiple antibiotics. Staphylococcus epidermidis is another staphylococcal species commonly seen as a commensal, but may cause opportunistic infections. These two closely related species may naturally co-colonize and inhabit the human skin and nose; thus it is important to develop methods to differentiate between them. Conventional differentiation methods (e.g., mannitol salt agar, coagulase test, Analytical Profile Index kits) require culturing and isolating the bacteria, while molecular methods based on polymerase chain reaction (PCR) or sequencing are culture independent, highly accurate, and sensitive. They may be objectively interpreted and can be adapted for high-throughput assays. Here, we aimed to develop a rapid and accurate method to differentiate mixtures of S. aureus and S. epidermidis in clinical isolates and microbiome samples. Using comparative genomics tools (e.g., MetaRef and PATRIC bioinformatics resource center), we compared the core and pan genomes of S. aureus and S. epidermidis to determine signature genes for each species. Among candidate genes, we chose the virulence genes, staphostatin B and staphostatin A as genetic biomarkers for S. aureus and S. epidermidis, respectively. We designed PCR primers that target specific sequences within each gene and tested them on DNA isolated from laboratory strains, clinical isolates, nasal isolates, and nasal swabs. Our developed method is simple, specific, sensitive, and can be applied to metagenomic samples as well as competition or co-evolution studies in which the two organisms are co-cultured.
The Effects of If-Then Plans on Weight Loss: Results of the 24-Month Follow-up of the McGill CHIP Healthy Weight Program Randomized Controlled Trial
Authors: Knauper Barbel , Shireen Huma , Carriere Kimberly , Frayn Mallory , Ivanova Elena , Xu Zhen , Lowensteyn Ilka , Sadikaj Gentiana , Luszczynska Aleksandra , Grover Steven , Investigators McGill CHIP Healthy Weight Program
Published: September 2019

Background: The NIH-developed Diabetes Prevention Program (DPP) is successful in achieving clinically significant weight loss in individuals with overweight/obesity when delivered one-on-one. However, due to high cost of implementation, the long-term effectiveness remains limited. In response, a group-based version of the program, called the National DPP, was developed. The average weight loss following participation in this program was only about 3.5% with low long-term weight loss maintenance. Purpose: We aimed to optimize weight loss outcomes of the National DPP by integrating the habit formation tool of if-then plans into the program. Results at 3 and 12 months of participation showed no between-group differences between standard and enhanced DPP but higher weight loss in both groups compared to the National DPP. This paper reports the long-term weight loss maintenance data following participation in the program. Methods: Of the 172 participants enrolled at the beginning of the study, data from 110 participants was available and analyzed at 24 months, i.e. 12 months following the end of the 12-month intervention. Results: No between-group difference in weight loss maintenance was seen. Pooled results showed a significant weight regain from 12 to 24 months, i.e. an average of 7.85lbs of the 20.36lbs lost. However, participants from both groups were still 12lbs or 6.13% lighter at 24 months than at baseline. Conclusion: If-then plans did not result in a higher percentage of weight loss at 24-month follow-up. However, at 24 months, both groups maintained a significant portion of the weight lost at the end of intervention.
The Effects of Two Exercise Modalities on Novel Cardiovascular Risk Factors in Overweight Women with Type 2 Diabetes: a Randomized Controlled Trial
Authors: Banitalebi Ebrahim , Faramarzi Mohammad , Ghahfarrokhi Majid Mardaniyan , Nasiri Samira
Published: September 2019

Background: The present study aims at investigating the effects of different exercise modalities (sprint interval training (SIT) and aerobic plus resistance training (A+R)) on novel cardiovascular risk factors (lipid accumulation product (LAP), Framingham risk score (FRS), the metabolic syndrome severity scores (Mets score), visceral adipose index (VAI), body adipose index (BAI), triglyceride-glucose index (TyG index), triglyceride glucose-waist circumference (TyG-WC), triglyceride glucose-waist circumference (TyG-BMI), HOMA β-cell, atherogenic index of plasma (AIP), and estimated glucose disposal rate (eGDR)) in overweight women with type 2 diabetes.Methods: Fifty-two overweight females with type 2 diabetes (T2D) (aged 45-60 years, BMI > 30, hemoglobin A1c (HbA1c) ≥ 6.5%) were assigned to either SIT (n = 17), A+R training (n = 17), or control groups (n = 18). Intervention consisted of SIT or A+R training for 10 weeks.Results: There were no significant changes in Mets in the SIT group after 10 weeks (p = 0.187). In addition, there were significant changes (improvements) in LAP (p < 0.001) and VAI (p = 0.002), FRS (p = 0.001), TyG index (p = 0.005), TyG-BMI (p = 0.012), TyG-WC (p < 0.001), AIP (p < 0.001), and eGDR (p = 0.001) in A+R training group after 10 weeks, as compared to the baseline.Conclusions: The results illustrated that exercise training modality independent of the mode of exercise training could be an effective intervention to improve some novel cardiovascular risk factors in women with type 2 diabetes.
Effect of low dose naloxone on the immune system function of a patient undergoing video-assisted thoracoscopic resection of lung cancer with sufentanil controlled analgesia — a randomized controlled trial
Authors: Yun Lin , Zhuang Miao , Yue Wu , Fangfang Ge , Qingping Wen
Published: September 2019

Background: Perioperative immune function plays an important role in the prognosis of patients. Several studies have indicated that low-dose opioid receptor blockers can improve immune function. Methods: Seventy patients undergoing video-assisted thoracoscopic resection of the lung cancer were randomly assigned to either the naloxone group (n=35) or the non-naloxone group (n=35) for postoperative analgesia during the first 48 hours after the operation. Both groups received sufentanil and palonosetron via postoperative analgesia pump, while 0.05μg·kg -1 ·h -1 naloxone was added in naloxone group. The primary outcomes were the level of opioid growth factor （OGF） and immune function assessed by natural killer cells and CD4 + /CD8 + . Second outcomes were assessed by the score of postoperative pain, postoperative rescue analgesia dose, postoperative nausea and vomiting (PONV). Results: The level of OGF in the naloxone group was significantly increased at 24 hours ( p ＜0.001) and 48 hours after the operation ( P <0.01). The natural killer cells ( P <0.05) and CD4+/CD8+ ( P <0.01) in the naloxone group increased significantly at 48 hours after the operation. The rest VAS score was better with naloxone at 12 and 24 hours after operation（ P <0.05）, and the coughing VAS score was better with naloxone at 48 hours after the operation（ P <0.05). The consumption of postoperative rescue analgesics in the naloxone group was lower (0.00（0.00-0.00）vs 25.00（0.00-62.50））， P <0.05). Postoperative nausea score at 24 hours after operation decreased in naloxone group（0.00 (0.00-0.00) vs 1.00 (0.00-1.00), P < 0.01). Conclusion: Infusion of 0.05μg·kg -1 ·h -1 naloxone for patients undergoing sufentanil-controlled analgesia for postoperative pain can significantly increase the level of OGF, natural killer cells, and CD4 + /CD8+ ，And also reduce the postoperative pain intensity, request for rescue analgesics, and opioid-related side effects. Trial registration: ChiCTR1900021043 on January 26, 2019.
Randomized Controlled Trial of a Novel, Digital, Chest Drainage System in Cardiac Surgery Patients
Authors: Barozzi Luca , Biagio Livio San , Meneguzzi Matteo , Courvoisier Delphine S. , Walpoth Beat , Faggian Giuseppe
Published: September 2019

Background: A new, self-contained, digital, continuous pump-driven chest drainage system is compared for the first time in a Randomized Control Trial to a traditional wall-suction system in cardiac surgery.Methods: 120 adult elective cardiac patients undergoing CABG and/or valve surgery were randomized to the study or control group. Both groups had similar pre/intra-operative demographics: age 67.8 vs. 67.0 years, Euroscore 2.3 vs. 2.2 and BSA 1.92 vs. 1.91 m2. Additionally, a satisfaction assessment score was performed by 52 staff members.Results: Given homogenous intra-operative variables, total chest-tube drainage was comparable among groups (566 vs. 640 ml; ns), but the study group showed more efficient fluid collection during the early post-operative phase (p = 0.006 and p = 0.01) due to continuous suction compared to 11.5 minutes off-suction time in the control group. Blood, cell saver transfusions and post-operative hemoglobin values were similar in both groups. The study group experienced drain removal after 29.8 vs 38.4 hours in the control group (ns). Seven crossovers from the Study to the Control group were registered but no patient had drain-related complications.Conclusion: The new, self-contained, digital, continuous pump-driven drainage system showed better early drainage of the chest cavity and was as reliable as conventional systems. Quicker drain removal might impact on ICU stay and reduce costs. Additional advantages are portable size, battery operation, patient mobility, noiseless function, digital indications and alarms. The satisfaction assessment of the new system by the staff revealed a higher score when compared to the traditional wall suction chest drainage system. This Randomized Control Trial was retrospectively registered on June 7, 2019 under ISRCTN 14884587. https://doi.org/10.1186/ISRCTN14884587
Helicobacter pylori infection and chronic gastritis; use of the Updated Sydney System in histopathological evaluation of gastritis
Authors: Ubhayawardana Nushka , Weerasekera Manjula , Samarasinghe Kamani , Premalal Sameera , Weerasekera Deepaka , Gunasekera Chinthika , Fernando Neluka
Published: September 2019

Objective
Helicobacter pylori is a major cause for chronic gastritis and further it is associated with development of peptic ulcer disease and gastric cancer. Therefore, the objective of this study was to classify gastritis according to the updated Sydney system guidelines and find the association of H. pylori with each of graded variable. Number of 152 dyspeptic patients who underwent upper gastro-intestinal endoscopy at a Teaching Hospital were enrolled. Of the 2 biopsies collected one was used for PCR to detect H. pylori. The other biopsy was fixed in formalin followed by paraffin embedding and stained with H&E stain. Gastritis was classified microscopically according to the updated Sydney system.

Results : Gastritis was reported over a wide age group ranging from 18-84 years with a mean age of 51 years. Based on histological findings, 12% of patients were diagnosed as H. pylori associated chronic active gastritis. There was no significant association between each graded variable and H. pylori positivity. Of the 152 dyspeptic patients 34 were positive by PCR for H. pylori infection. All the dyspeptic patients with H. pylori infection had chronic active gastritis, suggesting an etiologic role of the bacterium in the histologic lesion.
Smokeless tobacco use: prevalence and relationships with dental symptoms, nutritional status and blood pressure among rural women in Burkina Faso
Authors: Diendéré Jeoffray , Zeba N. Augustin , Nikiéma Leon , Kaboré Ahmed , Sawadogo W. Paul , Tougouma Somnoma Jean Baptiste , Tinto Halidou , Ouédraogo Arouna
Published: September 2019

Introduction: Sub-Saharan women use smokeless tobacco (SLT) more than smoked tobacco. Among Western Africa countries, the weighted prevalence estimated that SLT use in rural women was the highest in Burkina Faso (after Sierra Leone). This study aimed to assess the prevalence of SLT use and associated factors among rural women in Burkina Faso by using nationally representative data. Methods: We used variables from the 2013 Stepwise approach to Surveillance study, which provided sociodemographic characteristics, clinical (anthropometric, systolic blood pressure [SBP], diastolic blood pressure [DBP], dental symptoms), biological (total and high-density lipoprotein cholesterol and fasting blood sugar), tobacco and alcohol consumption data. Data for 1730 rural women were operated and we performed student’s, chi-square, and Fisher’s exact tests and logistic regression. Results: The prevalence of current SLT use was 13.8% (95% CI: 12.2-15.5). Significant risks for SLT use were presence of dental symptoms (adjusted odd-ratio [aOR] = 2.59; p = 0.0001), undernourishment (aOR = 1.78; p = 0.002), decrease in the unit of waist circumference (aOR = 0.98; p = 0 .023), decrease in unit of DBP (aOR = 0.97; p = 0.006), increase in the unit of SBP (aOR = 1.01; p = 0.017), or the increase in the unit of differential blood pressure (aOR = 1.01; p = 0.041). Co-use of alcohol was also a significant risk (aOR = 2.80; p = 0.0001). Conclusion: Prevalence of current SLT use was high among rural women in Burkina Faso, and significant concerns for users included alcohol co-use, occurrence of dental symptoms, undernourishment, and the increase in differential blood pressure. National Public Health interventions are needed to reduce SLT use and its health-related concerns.