bluuebunny/crossref_metadata_2025 huggingface dataset:
ЧИННИКИ СТРАТЕГІЧНОГО УПРАВЛІННЯ ВИНОГРАДАРСЬКО-ВИНОРОБНИМИ ПІДПРИЄМСТВАМИ В УМОВАХ ГЛОБАЛІЗАЦІЇ
Authors: Печко В.С.
Published: November 2024

Стаття присвячена теоретичному обґрунтуванню впливів та встановленню чинників стратегічного управління виноградарсько-виноробними підприємствами в умовах глобалізації. Проаналізовано теоретичні підходи, сутність та окреслено ключові ознаки процесу глобалізації. Здійснено бібліографічний аналіз тлумаченням поняття «чинник» та моделей, які описують процес прийняття стратегічних рішень. Встановлено сутність та особливості диференціації чинників (факторів) впливу на практику стратегічного управління на підприємствах. Запропоновано ландшафт чинників впливу на стратегічне управління виноградарсько-виноробними підприємствами в умовах глобалізації, який враховує вплив внутрішнього та зовнішнього середовища, а також безпосереднього оточення господарюючих суб`єктів, які перебувають у процесі постійної деформації внаслідок посилення глобалізаційних трендів.
СТАН ТА ТЕНДЕНЦІЇ РОЗВИТКУ ВІТЧИЗНЯНОГО РИНКУ ПРАЦІ В УМОВАХ ВОЄННИХ ДІЙ
Authors: Шостак Л.В. , Сур’як А.В.
Published: November 2024

Стаття присвячена аналізу стану та основних тенденцій розвитку вітчизняного ринку праці в умовах воєнних дій. У ній розглядаються ключові проблеми, що виникають через військовий конфлікт, такі як зростання безробіття, міграція робочої сили, внутрішнє переміщення населення, зміни в структурі попиту на робочу силу та адаптація підприємств до нових умов. Окрема увага приділяється впливу війни на окремі сектори економіки, розвитку віддаленої роботи та цифровізації, а також урядовим ініціативам, спрямованим на підтримку працівників і роботодавців. З початком війни ринок праці зазнав значних структурних змін, спричинених руйнуванням підприємств, інфраструктури, вимушеною міграцією населення та скороченням зайнятості у багатьох галузях економіки. Окрім того, ситуація погіршується через зростання рівня безробіття, переміщення значної частини населення всередині країни та за її межі, а також зниження попиту на робочу силу в окремих секторах. У такому контексті актуальним є вивчення механізмів адаптації ринку праці, пошук шляхів стабілізації та підтримки працездатного населення, а також розробка відповідних державних і приватних ініціатив для подолання кризи.
AI and Blockchain Integration: Enhancing Security and Transparency in Financial Transactions
Authors: Martinez Daniel , Magdalena Lena , Savitri Agnes Novalita
Published: November 2024

The integration of Artificial Intelligence (AI) and Blockchain is revolutionizing the financial sector, targeting crucial challenges like security and transparency. This paper explores the synergistic effects of AI and Blockchain on enhancing the security of financial transactions through advanced real-time fraud detection, anomaly identification, and decentralized transaction verification. Employing a comprehensive review of existing literature and case studies, the research investigates how AI’s capabilities in processing vast data volumes can be leveraged alongside Blockchain’s robust, immutable ledger system to mitigate risks in financial operations effectively. The findings reveal that integrating AI with Blockchain not only significantly improves the security by enabling the real-time detection of anomalies but also upholds the integrity and transparency of transactions across distributed ledgers. The results underscore the potential of AI-Blockchain technology to enhance financial transaction frameworks and highlight its capacity to support the achievement of the United Nations Sustainable Development Goals (SDGs), particularly SDG 8 (Decent Work and Economic Growth), SDG 9 (Industry, Innovation, and Infrastructure), and SDG 16 (Peace, Justice, and Strong Institutions) by fostering more transparent and secure economic environments. The conclusion of the study suggests further research on the scalability of AI-Blockchain integrations and their broader application across various industries, pointing towards a transformative impact on global financial practices.
Analytic study of Soret and Dufour effects on heat destructive Casson liquid movement past an infinite vertical plate
Authors: Malapati Venkateswarlu , P Rami Reddy , K Jaya Lakshmi
Published: November 2024

This article describes a scientific solution of an unsteady movement of a Casson liquid in an infinite vertical plate in the proxy mity of Soret and Dufour implementations. The non-dimensional structure of mathematical equations is integrated with convenient initial and boundary limitations by applying Laplace transform technique. The expressions for Casson liquid motion, temperature, concentration, Skin-friction, heat and mass transfer coefficients are displayed. In the course of discussions, the effects of main parameters are described. The liquid motion, temperature, and concentration profiles are presented graphically for Pr = 1 and Sc = 0.22 as well as for arbitrary values of other parameters. The study is significant in the application areas of chemical analysis and biological analysis, drug delivery, bacteria detection and some others. A comparative analysis of the current research with previously published work is presented.
Journal of Naval Architecture and Marine Engineering, 21 (1), 2024, pp. 27–40
Cuidados de enfermería a pacientes con insuficiencia respiratoria mixta en cuidados intensivos (CIE J96.0):
Authors: Vega Quispe Alexandra , Perez Quispe Jose , Bernardo Cachique Karen Jhearitza , Alvarado silva Ximena Alexandra , Quispe Casanova Alexander
Published: November 2024

Objetivo: Proporcionar intervenciones de enfermería que contribuyan a mejorar el estado de salud de la persona usuaria. Caso clínico: Paciente de sexo masculino de 32 años de edad, con antecedentes de depresión hace 5 años (aumenta la ingesta de alimentos) y obesidad mórbida, peso de 354 kg. Ingresa al hospital el día 24/2/24; refiere a los familiares “dolor torácico hace dos días, sensaciones de falta de aire y desmayo en dos oportunidades”. Sale de alta el 15/4/24. Métodos: El método es un estudio temático único. Se utilizó la teoría de 11 modelos funcionales de Marjory Gordon como una herramienta para procesar datos que utilizaban nomenclaturas taxonómicas internacionales de diagnósticos de enfermería 2021-2023. NANDA, NOC y NIC. Resultados: La evolución del usuario fue óptima, ya que los cuidados brindados se basaron en planes individualizados. El paciente sale de alta el día 15/4/24. Conclusiones: El diagnóstico de prioridad de patrón respiratorio ineficaz tuvo como puntuación de cambio con base en los indicadores: frecuencia respiratoria puntuación cambio (+3), disnea puntuación cambio (+4) y para el indicador de saturación de oxígeno puntuación cambio (+4).
Cuidados de enfermería a un paciente con quemadura de III grado en mano izquierda (T23) con AIPP:
Authors: Aranda Zabarburu Wendy Susy Del Pilar , Montalvo Fabian Ruth , Santivañez Ayala Yvanna , Arévalo Marcos Rodolfo Amado , Muñoz Pizarro Rosa María
Published: November 2024

Objetivo: Brindar intervenciones de enfermería que puedan mejorar y aliviar el estado de salud del usuario. Caso clínico: Paciente adulto joven de 36 años, de sexo masculino, sin antecedentes. El usuario ingresa al hospital con fecha 29/5/2024, por quemadura en mano izquierda a causa de la manipulación de pirotécnico en una fiesta. El paciente fue evaluado por cirugía plástica quienes indican su hospitalización para completar tratamiento de quemadura. Métodos: El método es un análisis de caso único de enfoque cualitativo. Se aplicó como instrumento de valoración la teoría de 11 patrones funcionales de Marjory Gordon. Para el desarrollo de datos, se utilizaron las nomenclaturas taxonómicas internacionales de diagnósticos enfermeros 2021-2023 de NANDA, NOC y NIC. Resultados: El progreso del usuario fue parcial en vista a la gravedad de la quemadura, proceso de granulación y epitelización. Se brindó una atención de calidad y calidez enfocándonos también en la parte emocional, proporcionando un cuidado individualizado hasta lograr una evolución óptima. Conclusiones: Para el diagnóstico priorizado dolor agudo tuvo como puntuación de cambio con base en los indicadores: dolor referido puntuación de cambio (+3), expresiones de facie de dolor puntuación de cambio (+3), muecas de dolor puntuación de cambio (+3).
Cuidados de enfermería a un paciente con toxoplasmosis cerebral (B58) en un hospital nacional:
Authors: Rua Principe Esmeralda Akemy , Albino Palacin Elena Milagros , Huamanchao Ochochoque Pamela Beatriz , Rojas Trujillo Juan Esteban , Arevalo Marcos Rodolfo Amado
Published: November 2024

Objetivo: Describir las intervenciones de enfermería que mejoren el estado de salud del paciente con toxoplasmosis cerebral y VIH. Caso clínico: Paciente varón de 28 años, ingresa al hospital con fecha 14/2/24, con diagnóstico de VIH, sin tratamiento, presenta desviación de la mirada, cefalea persistente, debilidad, pérdida de peso y rigidez en extremidades. Se confirma toxoplasmosis cerebral, sífilis y citomegalovirus, con un recuento de CD4 bajo y exámenes negativos para tuberculosis. Métodos: Es un estudio de caso clínico único de enfoque cualitativo. Se utilizó como instrumento de valoración la teoría de 11 patrones funcionales de Marjory Gordon para el proceso en el cual se implementaron planes de cuidados de enfermería basados en diagnósticos NANDA, intervenciones NIC y resultados esperados NOC. Resultados: Las intervenciones al paciente fueron poco favorables, ya que su enfermedad está avanzada, pero se logra estabilizar la temperatura del paciente, reducir el dolor y mejorar el cuidado en el estado nutricional; asimismo, a la madre se le enseñan los cuidados en casa, ya que el paciente es dado de alta por el médico tratante. Conclusión: En este caso clínico se priorizó la hipertermia que tuvo una puntuación en los indicadores: temperatura cutánea aumentada (+2), hipertermia (+2) e irritabilidad (+2).
El uso de las herramientas digitales en educación patrimonial, ¿es un desafío?
Authors: Venturo Huares Rocio Verna
Published: November 2024

Contribución al debate 30 de revista PH sobre el  Uso y abuso de las herramientas digitales en educación patrimonial.
Integrating Information Technology Terminology Into English for Specific Purposes (ESP) Classes
Authors: Khamdamova Gulshan , Narziyev Inobat , Bozorova Viloyat , Sharipova Dilnoza , Khatamova Gulrux
Published: November 2024

English for Specific Purposes (ESP) courses aim to equip students with the language proficiency essential for their selected occupations or academic fields. In the contemporary digital landscape, information technology (IT) has emerged as a vital component across various industries, making it imperative for individuals to gain a comprehensive understanding of IT terminology. This article delves into the significance of teaching IT vocabulary within ESP lessons, highlighting the critical role that language plays in professional success. In addition, it offers practical strategies and recommendations for effectively integrating IT terminology into language acquisition, ensuring that learners can navigate the complexities of the IT landscape with confidence.
Aspect-Based Sentiment Analysis for Online Products
Authors: Ladella Sai Prakhyaath , Joginpally Sindhuja , Ranjit K. Noah
Published: November 2024

A number of resources are now available for gauging public opinion about businesses, products, services, brands, and events because of the advent of e-commerce. Customers may find it difficult to distinguish between legitimate assessments and biased or false reviews, which leads to worse goods or services. Aspect-based sentiment analysis is utilized in this study to develop a natural language processing model to examine customer reviews and comments to ascertain the sentiment expressed towards certain qualities or components of a good or service. A few procedures involved in this undertaking include aspect extraction, sentiment classification, training, feature extraction, and dataset preparation. The T5 model will be used to train the model using a dataset of customer reviews, and it will be evaluated using a variety of performance measures, including accuracy (84.62%), precision (84.58%), recall (84.62%), and F1-score (83.39%). The project's findings will help customers locate services that meet their needs, and they will also assist businesses in learning more about the advantages and disadvantages of their goods and services.
Herpes Zoster oftálmico após vacinação contra Covid-19: Uma nova perspectiva aos profissionais da saúde
Authors: Barbosa Amanda Dantas , Vieria Leonardo Trajano de Oliveira , Lourenço Paulo Eduardo de Lima , Rodrigues Rayanne do Nascimento , Pereira Ana Karine Farias da Trindade Coelho
Published: November 2024

O Herpes Zoster é uma doença marcada pela reativação do Vírus Varicela-Zoster (VVZ). O ramo oftálmico do nervo trigêmeo pode ser acometido pelo patógeno, ocasionando o Herpes Zoster Oftálmica (HZO). Nesse contexto, a reativação do vírus no ramo oftálmico do nervo trigêmeo foi frequentemente descrita na literatura como possivelmente associada à vacinação contra o SARS-CoV-2, cujas ocorrências foram escassas, mas estatisticamente significativas. Os estudos também apontaram um padrão singular na proporção de acometidos pelo HZ de acordo com a natureza da vacina, de modo que aquelas que utilizam RNAm como antígeno foram as mais frequentes. Assim, o objetivo deste estudo foi de relatar o caso de uma mulher brasileira de 23 anos, imunocompetente, que desenvolveu HZO cerca de um mês e meio após tomar a segunda dose da CoronaVac®, vacina de vírus inativado, e apresentou queixa de dor em formas de pontadas e ardência na região supraorbital e orbital da hemiface esquerda, culminando com a formação de lesões vesiculares dolorosas e avermelhadas. Conclui-se que existem evidências relacionando a vacinação e a reativação relatada, sendo importante a disseminação desse conhecimento entre profissionais da saúde, garantindo a segurança da vacinação dos indivíduos que fazem parte do grupo de risco, sem desestimular sua imunização.
Inter-relação diabetes e doença periodontal: Uma revisão de literatura
Authors: Silva Isabella Leal , Oliveira Victoria Mota , Campos Marta Rosado de Oliveira , Melo Neto José Pereira de , Veras Eduardo Souza de Lobão
Published: November 2024

Introdução: O diabetes melittus é um distúrbio metabólico complexo, descrito por hiperglicemia crônica. Uma produção diminuída de insulina. No diabetes há modificação no metabolismo dos lipídios e proteínas. Há dois tipos principais de diabetes, tipo 1 e tipo 2, com vários tipos secundários menos comuns. A doença periodontal, é uma das doenças inflamatórias crônicas mais comuns, que pode ocasionar perda dentaria, devido a destruição gradual do tecido conjuntivo ao redor dos dentes. Ocorre principalmente em adultos e ao decorrer da idade sua incidência aumenta. É uma inflamação que se estende e causa destruição dos tecidos e reabsorção óssea alveolar. Objetivo: O presente estudo tem como objetivo realizar uma revisão da literatura afim de elucidar a inter-relação do diabético e a doença periodontal. Metodologia: Este trabalho consiste de uma revisão de literatura. Resultados: Os achados demonstram a intricada conexão entre diabetes e doença periodontal, evidenciando a importância de uma abordagem multidisciplinar no tratamento. Há um acordo geral de que otimizar a comunicação entre os profissionais e implementar estratégias de cuidado integradas pode não apenas aprimorar os resultados de saúde dos pacientes, mas também diminuir os custos ligados ao tratamento dessas condições interligadas. Conclusão: A revisão confirmou a forte inter-relação entre diabetes melito e doença periodontal, com ambos influenciando negativamente a progressão um do outro. A integração entre cuidados médicos e odontológicos é essencial para melhorar o controle glicêmico e a saúde periodontal dos pacientes, destacando a necessidade de uma abordagem multidisciplinar no tratamento.
Relato de caso: Hiperestesia em um felino, no município de Cacoal- RO no ano de 2024
Authors: Pedro Emily Lorrainy Nunes , Meneguelli Mayra
Published: November 2024

A hiperestesia felina, frequentemente referida como síndrome da pele ondulada ou doença do gato nervoso, é uma condição rara e ainda mal compreendida que afeta gatos. Os principais sintomas incluem hipersensibilidade, espasmos musculares, lambedura excessiva e outros comportamentos anormais. O diagnóstico é desafiador e geralmente envolve uma combinação de histórico clínico, exames físicos, e exclusão de outras condições que podem apresentar sintomas semelhantes. Desta forma, este relato busca descrever um caso de hiperestesia felina atendido em Cacoal-RO, onde o seu diagnóstico foi por meio da análise dos sinais clínicos, os resultados dos exames laboratoriais e a anamnese. O manejo terapêutico envolveu o uso de dipirona, tramadol, midazolam e dexametasona, ressaltando a importância de uma abordagem multimodal para o controle da dor, da inflamação e da ansiedade, com o objetivo de melhorar a qualidade de vida do animal.
A relação do ômega-3 no prognóstico da depressão em adultos: Revisão integrativa
Authors: Viana Jamile da Silva , Araújo Maria Cláudia Moura Buenos Aires , Paz Diego Damasceno
Published: November 2024

A depressão é um transtorno mental caracterizado por uma tristeza constante, desinteresse em atividades prazerosas, e em casos graves, pensamentos de suicídio. O ômega-3 é um ácido graxo essencial importante para a saúde humana, e existem três principais tipos de ômega-3, o ácido eicosapentaenoico (EPA), o ácido docosahexaenoico (DHA) e o ácido alfa-linolênico (ALA). O ômega-3 pode exercer um papel na saúde mental e a sua deficiência pode estar associada ao aumento da depressão. O objetivo do presente artigo foi realizar uma revisão da literatura sobre a relação do ômega-3 no prognóstico da depressão em adultos. Para isso, foi adotada a estratégia PICO para a elaboração da pergunta norteadora e a busca dos artigos foi realizada nas bases de dados PubMed e Portal de Periódicos da CAPES. Na escolha dos artigos, realizou-se a leitura dos títulos, dos resumos e, por fim, os textos completos. Foram identificados 575 artigos, porém, somente 04 artigos foram considerados elegíveis. Os estudos apontam a relação entre o ômega 3 e depressão, destacando ensaios clínicos que mostram o efeito modesto dos ácidos graxos poli-insaturados n-3, mas com significância clínica questionável, e apesar do ômega 3 apresentar efeitos modestos na redução da depressão, as evidências são limitadas, necessitando-se de mais estudos rigorosos para entender a sua real eficácia.
Impacto da atividade física na prevenção e controle da obesidade infantil: Uma revisão integrativa
Authors: Leal Derick Patrick Bentes , Costa Victor Ângelo Silva da , Viana Joaquim Albuquerque , Boaventura Alessandra Bárbara César de Freitas , Monego Estela Aita
Published: November 2024

A obesidade infantil, um problema de saúde pública crescente, apresenta múltiplos fatores associados, como hábitos alimentares inadequados e sedentarismo. A presente revisão integrativa teve como objetivo analisar a eficácia da atividade física na prevenção e controle da obesidade em escolares, com base em estudos publicados entre 2018 e 2023. A prática regular de atividade física emerge como uma estratégia fundamental para combater a obesidade infantil, promovendo a perda de peso, melhorando a composição corporal e reduzindo o risco de doenças crônicas. A escola desempenha um papel crucial nesse processo, oferecendo um ambiente propício para a prática de atividades físicas e a educação em saúde. No entanto, a pesquisa revela que ainda há lacunas na implementação de programas eficazes de atividade física nas escolas. A revisão destaca a importância da atuação conjunta da escola, da família e dos profissionais de saúde para promover hábitos de vida saudáveis desde a infância. A promoção da atividade física na escola deve ser integrada ao currículo escolar e envolver todos os professores, não se limitando apenas às aulas de Educação Física. Além disso, é fundamental que a família ofereça apoio e incentive a prática de atividades físicas em casa. Em conclusão, a atividade física é uma ferramenta poderosa para prevenir e controlar a obesidade infantil. A implementação de programas de atividade física nas escolas, associada a outras intervenções, como a promoção de hábitos alimentares saudáveis, é fundamental para garantir que as crianças tenham uma vida mais saudável e ativa.
Social Audit: A Key Enabler for Enhancing Outcomes of Social Projects
Authors: Gupta S.K. , Porwal Ashish
Published: November 2024

The focus on sustainable development encompassing dimensions of inclusive and equitable growth is driving the catalytic role of Civil Society Organizations the world over. As these organizations operate at the grass root level, they are able to plan and execute relevant and contextual social projects and programs for bringing about a desirable and positive change in society.A social audit is a procedure used to assess, document, and enhance an organization's behaviour and performance as well as gauge its impact on society.It can be conducted internally or externally and looks at how a certain program, project, or organization is affecting society. To put it briefly, social audits assist businesses in striking a balance between social duty and profits.
Impact Assessment of Community Outreach Programs Run by Higher Education Institutions: Students’ Perception
Authors: Maheshwari Meenu , Goyal Shobhna
Published: November 2024

Outreach is the process of addressing gaps in Government services for the unreached, integrating them into the mainstream society. Higher education institutions play a crucial role by reaching communities directly, counseling and implementing policies with the help of youth and resources. These initiatives not only enrich research but also provide real-time learning opportunities to students. HEIs are increasingly recognizing the importance of integrating social responsibility and community engagement into their vision and mission to enhance teaching, research and service quality. Developing institutional mechanisms for community engagement as part of the curriculum is crucial for achieving socio-economic goals. Despite the available literature, comprehensive surveys on HEIs' outreach programs in Haryana's State Universities are lacking. This study seeks to fill this gap by assessing students' perceptions, satisfaction levels and institutional avenues for community engagement programs. About 158 student volunteers from 5 State Universities in Haryana, were surveyed using structured questionnaire and most respondents were supportive to HEIs' community outreach expressing satisfaction with institutional engagement activities. Gender, age, and duration of association don't influence opinions, nor does varying engagement time affect satisfaction levels significantly.
Strengthening Social Audits in India: A Bibliometric Perspective
Authors: Arora Shivani , Mehta Meera , Piplani Kaashvi
Published: November 2024

This study is focused on the deep analysis of the research done in the field of social audit in India. With the help of Bibliometric analysis on the data derived from Scopus, the findings would benefit the practitioners in the field. The study presents the crisp findings of the top cited publications in the field and can also be used to promote collaborations between industry, practitioners and researchers/ academicians for research in the implementation of social audit and its success.
MSP and Cost of Cultivation of Crops in Relation to Mechanisation of Cultivation of Crops
Authors: Genteela Rambabu , Chaitanya K.Krishna
Published: November 2024

Agricultural cost is the key to finding the farmers’ cost for a particular crop. India is a nation where a sizable section of the population relies on the agriculture sector, yet it is the only industry that consistently experiences challenges and produces at a rate that is lower than what is anticipated. Indian farms must be mechanised in order to boost input usage effectiveness, decrease human labour-intensive tasks, raise production and productivity of food-grains, lower production costs, and handle difficulties with labour shortages in agriculture and timely farm operations. The use of engineering and technology in agricultural operations to perform a task more effectively and increase production is known as farming mechanization. Mechanization will be used in various stages of the cultivation process where the human intervention will be reduced. Improving crop production involves a combination of factors ranging from selecting the right crop varieties and implementing effective agricultural practices to managing resources efficiently and mitigating risks. Mechanization in the process of cultivation involves the use of various machines and equipment to perform agricultural tasks more efficiently and effectively. Here's how mechanization is applied at different stages of the cultivation process: land preparation, planting, weed control, irrigation, fertilization, crop monitoring, harvesting etc.
Decoding Creditworthiness: Leveraging Big Data Analytics for Risk Assessment in Credit Appraisals
Authors: Kataria Kalpana , Sharma Divya
Published: November 2024

The aim of the present study is to explore the role of Big Data Analytics (BDA) in assessing the risk in credit appraisals also, to discuss credit assessment and its importance. The study also explores the Credit Risk Analytics (CRA) the threats and restrictions of BDA in credit appraisal as well as opportunities for data in banks.
Cash Back for those who Generate New Employment Deduction under Section 80JJAA of the Income Tax Act, 1961: - Analysis, Challenges & Courts’ Decisions
Authors: Suvagiya Atul P.
Published: November 2024

The benefit of deduction under section 80JJAA of the Income-tax Act makes the business houses highly motivated for generating new employment because additional deduction of 30 per cent for three years (aggregate 90 per cent) can reduce the handsome amount of tax liability. It is important to note that this additional benefit is allowed over and above the deduction of 100 per cent of wages/salaries under section 37 of the Act. A researcher has made an attempt to analyse the provisions of this section and dealt with its practical aspects.
Bancassurance in India: Opportunities, Challenges, and Future Prospects
Authors: Shukla Pooja , Taneja Bhavna
Published: November 2024

The insurance and banking sector of India has witnessed a new opportunity after the opening up of the insurance sector in India in the form of bancassurance which is a practice by which banks are used as the channel of distribution for selling insurance products. This article explores the evolution, opportunities, challenges and prospects of bancassurance. It also contains a comprehensive analysis of the regulatory framework, market trends, and consumer behavior to provide valuable insights into the shaping of the dynamic landscape of the bancassurance business in India. The article also makes recommendations to all the stakeholders for harnessing opportunities and addressing the challenges of the domain.
Enabling Professional Services: A Catalyst for Growth of GIFT-IFSC
Authors: C M Sathyaraj
Published: November 2024

The purpose of this article is to highlight one of the most profound financial sector reforms undertaken by the Government of India in the recent past with establishment of GIFT-IFSC recognizing the imperative of integrating with the global financial system while acknowledging the challenges of immediate full capital account convertibility, and adopted a strategic "enclave approach". Subsequently, recognizing the need for a cohesive regulatory framework to nurture the IFSC ecosystem, the Government of India in the Ministry of Finance took a decisive step in December 2019 with the passage of the International Financial Services Centres Authority (IFSCA) Act for establishment of IFSCA. The IFSCA empowers GIFT-IFSC to realize its full potential as a dynamic hub for global finance, driving India's aspirations of becoming a leading player in the global financial arena. The article also talks about the importance of Professional Services providers including Cost and Management Accountants in the growth and success of an International Financial Services Centres by showcasing their contributions in the development of the financial services market in an international finance ecosystem.
Supplementing With Which Form of Creatine (Hydrochloride or Monohydrate) Alongside Resistance Training Can Have More Impacts on Anabolic/Catabolic Hormones, Strength and Body Composition?
Authors: Eghbali E , Arazi H , Suzuki K
Published: November 2024

The purpose of this study was to determine the effects of resistance training (RT) alongside creatine-hydrochloride (Cr-HCl) or creatine monohydrate (CrM) supplementation on anabolic/catabolic hormones, strength, and body composition. Forty participants with an age range of 18-25 years were randomly divided into four groups (n=10): RT+Cr-HCl (0.03 g.kg-1 of body mass), RT+CrM-loading phase (CrM-LP) (0.3 g.kg-1 of body mass for five days (loading) and 0.03 g.kg-1 body mass for 51 days (maintenance)), RT+CrM-without loading phase (CrM-WLP) (0.03 g.kg-1 body mass), and RT+placebo (PL). The participants consumed supplements and performed RT with an intensity of
70-85 % 1RM for eight weeks. Before and after the training and supplementation period, strength (1RM), body composition (percent body fat (PBF), skeletal muscle mass (SMM), muscular cross-sectional area (MCSA)) and serum levels of testosterone, growth hormone (GH), insulin-like growth factor-1 (IGF-1), cortisol, adrenocorticotropic hormone (ACTH), follistatin and myostatin were measured. The results showed that in the supplementation groups, strength, arm and thigh MCSA, and SMM significantly increased, and PBF significantly decreased (P≤0.05); this change was significant compared to the PL group (P≤0.05). In addition, the results showed a significant increase in GH, IGF-1 levels, the ratio of follistatin/myostatin, testosterone/cortisol (P≤0.05), and a significant decrease in cortisol and ACTH levels (P≤0.05) in the supplementation groups. Hormonal changes in GH, IGF-1, testosterone/cortisol, cortisol, and ACTH levels in the supplementation groups were significant compared to the PL group (P≤0.05). The results showed that CrM and Cr-HCl significantly enhanced the beneficial effects of RT on strength, hypertrophy, and hormonal responses, with Cr-HCl showing no benefit over CrM.
Strategi Peningkatan Peran Pemangku Kepentingan Ditinjau dari Model Penta Helix dalam Pengelolaan Smart City Kota Semarang
Authors: Stg Febrina
Published: November 2024

Smart City merupakan suatu inovasi yang diterapkan di Kota Semarang sebagai alternatif solusi untuk menghadapi tantangan dan permasalahan perkotaan dengan mengimplementasikan konsep integrasi teknologi informasi dan komunikasi (TIK) berbasis Internet of Things (IoT). Keberhasilan penerapan smart city tidak terlepas dari peran pemangku kepentingan sebagai aktor pembangunan dalam menggerakkan inovasi, pelayanan publik dan investasi Kota Semarang sebagai pusat ekonomi dan pertumbuhan ekonomi Jawa Tengah. Penelitian ini bertujuan untuk mengidentifikasi, memetakan dan merumuskan peran pemangku kepentingan ditinjau dari model Penta Helix yaitu pemerintah, swasta, akademisi, media massa dan masyarakat dengan konsep kolaborasi dalam pengelolaan Quick Wins Semarang Smart City berdasarkan dokumen Peraturan Walikota Semarang Nomor 26 tahun 2018. Metode penelitian yang digunakan adalah metode deskriptif kualitatif, terdiri dari data primer melalui wawancara secara langsung (face-to-face) dengan informan inti dan data sekunder melalui studi literatur dan penelitian terdahulu terkait topik penelitian. Teknik analisis data menggunakan analisis stakeholders untuk memperoleh kerangka kerja yang kuat untuk mengetahui sejauh mana peran pemangku kepentingan dalam memaksimalkan penerapan smart city. Hal ini membantu mengidentifikasi kompleksitas hubungan antarpihak, meminimalkan risiko, dan menciptakan lingkungan yang mendukung inovasi berkelanjutan dalam menghadapi kondisi perkotaan yang dinamis dan adaptif terhadap perubahan tersebut. Dengan mengetahui permasalahan dan potensi secara substansial dan teknis, maka dapat menjadi usulan strategi peningkatan peran pemangku kepentingan yang selanjutnya dapat menjadi rekomendasi kebijakan pemangku kepentingan demi perbaikan kualitas pelayanan publik Kota Semarang.
 
Kata kunci: smart city; quick wins; model Penta Helix; kolaborasi; pemangku kepentingan
Evaluasi Program Makmur Pupuk Indonesia dalam Meningkatkan Ekosistem Usaha Perkebunan Sawit Rakyat Menggunakan Kriteria OECD-DAC: Studi Kasus di Provinsi Riau
Authors: Nasution Zulfi Prima Sani
Published: November 2024

Tantangan utama dalam subsektor perkebunan kelapa sawit, khususnya pada perkebunan kelapa sawit rakyat, adalah peningkatan produktivitas. Rendahnya produktivitas disertai fluktuasi harga input dan harga jual komoditas sangat berdampak pada ketidakstabilan pendapatan petani. Untuk meningkatkan produktivitas sawit rakyat, PT Pupuk Indonesia Holding Company (PIHC) menginisiasi Program Makmur. Program ini bertujuan untuk mengatasi berbagai tantangan yang dihadapi pekebun rakyat, antara lain terbatasnya akses terhadap pupuk, fluktuasi harga pupuk, dan kendala finansial yang menghambat penerapan Good Agricultural Practices (GAP). Tujuan penelitian ini yaitu mengevaluasi tingkat keberhasilan Program Makmur, mulai dari proses bisnis, ekosistem kemitraan, peran dari masing-masing pihak. Penelitian ini akan menilai relevansi, efisiensi, efektivitas, dampak, dan keberlanjutan program melalui pendekatan kuantitatif dan kualitatif berdasarkan pedoman evaluasi proyek dan program yang diterbitkan oleh Organization for Economic Cooperation and Development – Development Assistant Committee (OECD-DAC 2021). Penelitian berfokus pada tiga koperasi pekebun sawit yang berlokasi di Kabupaten Kampar, Provinsi Riau. Hasil evaluasi menyimpulkan bahwa program Makmur – Pupuk Indonesia telah berhasil memfasilitasi akses terhadap pupuk berkualitas dan mendorong kolaborasi antar pemangku kepentingan. Namun, terdapat tantangan yang harus diatasi, khususnya dalam meningkatkan kesadaran petani, meningkatkan efisiensi program, dan memastikan dampak jangka panjang dan keberlanjutannya. Program Makmur pada tanaman kelapa sawit rakyat di Riau secara keseluruhan di ketiga koperasi dikategorikan “Sebagian Berhasil atau Partially Successful”.
Kata Kunci: kesinambungan, pekebun rakyat, kelapa sawit, produktivitas, pupuk, Program Makmur
Antifungal Potential of Corolla Extracts from Butea monosperma and Calotropis procera against Wheat Fungal Diseases Identified from District Bhimber, Azad Kashmir
Authors: Hussain Tanveer , Moqaddas Aleeza , Ishtiaq Muhammad , Khan Faheem Ahmed
Published: November 2024

The present study documented the fungal diseases of wheat crop and their biological management by using corolla extracts of two medicinal plants ‘Butea monosperma and Calotropis procera’. The highest infection rate (57.14%) was observed against Fusarium graminearum while minimum infection rate (20.8%) was observed against Blumeria graminis pathogen. The highest severity rate was recorded at 80% while the minimum severity rate was recorded as 40%. The antifungal responses of corolla extracts have been applied against the most prevalent fungal pathogens of wheat. The highest zone of inhibition was observed in methanolic extract of Butea monosperma petals against fungi Alternaria triticina. Similarly, the maximum zone of inhibition was observed in methanolic extract of Calotropis procera against fungi Fusarium graminearum. It was indicated that the treated wheat plants produced better yield than non-treated plants.  It was observed that the Calotropis procera showed more potential for the management of fungal diseases than Butea monosperma. So, it was concluded that the C. procera petals are more efficient because they have rich chemical compositions. Therefore, these were considered very effective against selected fungal pathogens of wheat.
Effect of cereal rye cover crop termination timings on weed control and corn yield under a two-pass herbicide program
Authors: Godar Amar S. , Norsworthy Jason K. , Barber L. Tom
Published: November 2024

Cover crops, including cereal rye, are generally known to suppress weeds in various cropping systems; however, research on their effective use is lacking. This study investigated the effects of different cereal rye termination timings on weed control and corn performance in a two-pass herbicide program across 5 site-years (2021–2023) in Arkansas, USA. The herbicide program consisted of one application at cereal rye (Secale cereale) termination (cereal rye environment) or at corn (Zea mays) planting (conventional system) and another at the V4 corn stage. Palmer amaranth (Amaranthus palmeri) at V4 corn was better controlled in cereal rye environments regardless of its termination timing (>75%) than in the conventional corn system (<50%), and the control was generally excellent in both systems 4 weeks later, with subtly greater control in the cereal rye environments. In contrast, yellow nutsedge (Cyperus esculentus) control, in general, was slightly less in the cereal rye environments than in the conventional system. Barnyardgrass (Echinochloa crus–galli) and broadleaf signalgrass (Urochloa platyphylla) control was similar to that of Palmer amaranth, especially at the V4 corn stage, with clear benefits in its control with the later termination timings. Corn height was greater (by 8% to 10%) in cereal rye environments terminated at 1 or 2 weeks after corn planting compared to the conventional system or other cereal rye environments. Corn yield was similar between the conventional system and the cereal rye environments terminated before corn planting; however, the yield was 16% to 22% less with those terminated at or after corn planting. These findings indicate the constrained use of cereal rye in corn, with its termination time optimized for 2 weeks before corn planting. Further research could identify factors that mitigate the yield loss from delayed cereal rye termination and improve its use as a cover crop in corn.
Sensing equivalent kinematics enables robot-assisted mirror rehabilitation training via a broaden learning system
Authors: Miao Qing , Fu Xueming , Chen Yi-Feng
Published: November 2024

Introduction

Robot-assisted mirror therapy has been widely developed to help remodeling of premotor cortex for patients suffering from motor disability of limbs. Nevertheless, it is difficult to achieve real-time adaptive control in robot-assisted mirror rehabilitation training, particularly for patients with varying levels of limb impairment.

Methods

This paper proposes an equivalent kinematics control framework based on the Broaden Learning System model for active robotic mirror rehabilitation, where people’s bilateral upper limbs actively perform mirror movements to enhance the impaired limb’s participation. The framework accommodates a broaden learning model from sensing multi-kinematic features to adjust the robotic damping coefficient in assisting human participants to complete mirror-symmetry training. Besides, in order to adapt to inter-patients’ variability with different disability levels, a challenge-level modification interface is also fused for safer training. This model is verified by additional symmetry indicator such as position trajectory error and force.

Results

Experimental results show that the weaker subjects can also maintain mirror movement with the stronger subjects under the help of this model and verify the performance of framework in mirror-symmetry effects and movement smoothness. This leads us to believe that the framework can safely and efficiently assist human participants in completing mirror-symmetry movement.

Discussion

The framework has the potential to improve outcomes in smoother and safer mirror-symmetry training by sensing multi-kinematic features. Future studies are necessary to involve clinical trials with actual patients.
Multicellular 3D models to study myocardial ischemia–reperfusion injury
Authors: Peletier Merel , Zhang Xiaohan , Klein Scarlett , Kroon Jeffrey
Published: November 2024

Coronary heart disease is a major global health threat, with acute myocardial ischemia–reperfusion injury (IRI) being a major contributor to myocardial damage following an ischemic event. IRI occurs when blood flow to ischemic tissues is restored and exacerbates the cellular damage caused by ischemia/hypoxia. Although animal studies investigating IRI have provided valuable insights, their translation into clinical outcomes has been limited, and translation into medical practice remains cumbersome. Recent advancements in engineered three-dimensional human in vitro models could offer a promising avenue to bridge the “therapeutic valley of death” from bench to bedside, enhancing the understanding of IRI pathology. This review summarizes the current state-of-the-art cardiovascular 3D models, including spheroids, organoids, engineered cardiac microtissues, and organ-on-a-chip systems. We provide an overview of their advantages and limitations in the context of IRI, with a particular emphasis on the crucial roles of cell–cell communication and the multi-omics approaches to enhance our understanding of the pathophysiological processes involved in IRI and its treatment. Finally, we discuss currently available multicellular human 3D models of IRI.
UPLC-ESI/MSn metabolic profiling of Cedrela odorata L. and Toona ciliata M. Roem and in vitro investigation of their anti-diabetic activity supported with molecular docking studies
Authors: El-Nashar Heba A. S. , Al-Qaaneh Ayman M. , Bhuia Md. Shimul , Chowdhury Raihan , Abdel-Maksoud Mostafa A. , Ebaid Hossam , Malik Abdul , Torequl Islam Muhammad , Aufy Mohammed , Elhawary Esraa A.
Published: November 2024

Introduction

The genus Cedrela is one of the phytochemically rich genera of the family Meliaceae. In this study, two Cedrela species, namely, Cedrela odorata and Toona ciliata M. Roem (formerly Cedrela toona), were selected for in-depth phytochemical profiling with the aid of UPLC-ESI/MSn analysis followed by evaluation of their anti-diabetic potential through assessment of in vitro α-amylase and α-glucosidase inhibitory effects, alongside the molecular docking studies on these target enzymes.

Materials and methods

UPLC-ESI/MSn technique was applied to tentatively identify the extracts. The anti-diabetic properties were assessed using BioVision α-amylase and α-glucosidase inhibitor screening kits. Further, the molecular docking studies utilized PyRx® and Discovery Studio software.

Results and discussion

The UPLC-ESI/MSn analysis led to the identification and quantification of 55 metabolites with their fragmentation patterns for the first time for these two species. Flavonoids represented the main identified class, followed by phenylpropanoids, terpenes, tannins, and others. The two species showed potent enzyme inhibition, where C. odorata and C. toona significantly inhibited α-amylase (IC50 = 4.83 ± 0.01 and 3.50 ± 0.03 μg/mL) compared to pioglitazone (IC50 = 2.17 ± 0.23 μg/mL), while their α-glycosidase inhibitory properties were also potent with (IC50 = 7.17 ± 0.01 and 6.50 ± 0.69 μg/mL), respectively, compared to acarbose (IC50 = 4.83 ± 1.02 μg/mL). The enzyme inhibitory activities were further confirmed by in silico molecular docking of the main identified components with the respective binding sockets in both α-amylase and α-glycosidase enzymes.

Conclusion

These promising results could pave the way for a novel discovery of natural phytoconstituents with potent anti-diabetic activity.
Modulation of metabolic pathways and EndMT inhibition by a traditional Chinese herbal formula in the treatment of high-risk infections
Authors: You Hailing , Bu Kailai , Chen Liping , Sun He , Suyang WangAo , Feng Gaofei , Chen Yuan
Published: November 2024

Background

Herbal products have long been utilized as remedies for various disease conditions, including infections. This study investigates the therapeutic mechanism of a traditional Chinese herbal combination in treating high-risk HPV infections.

Methods

The herbal formula was prepared using common herbs: dry Millettia speciosa, Guanzhong (a spermatophyte), Sarsaparilla, White Fruit, and Cockscomb Flower. Eight female patients diagnosed with high-risk HPV were enrolled from January to September 2023 at Shenzhen Hospital of Beijing University of Traditional Chinese Medicine. Cervicovaginal secretions were collected before and after treatment with the herbal remedy and analyzed using non-targeted metabolomics techniques. In vitro studies were conducted using HeLa cells to determine the optimal effective concentration of the remedy, assessed via the CCK8 method. The proliferation and migration of HeLa cells were evaluated using Transwell assays. Quantitative PCR was employed to measure mRNA levels of endothelial-to-mesenchymal transition (EndMT) markers, including VE-Cadherin, eNOS, α-SMA, and Snail.

Results

In vivo, significant alterations in cervicovaginal secretion metabolites post-treatment were observed through PCA, OPLS-DA, and volcano plot analyses. KEGG enrichment analysis highlighted crucial signaling pathways such as arginine and proline metabolism, purine metabolism, glycerophospholipid metabolism, and phenylalanine metabolism, indicating the herbal combination’s systemic effects on patients. In vitro experiments demonstrated a dose-dependent reduction in HeLa cell proliferation and migration, confirmed by scratch and Transwell assays. Additionally, qPCR analysis revealed down-regulation of α-SMA and Snail, and up-regulation of VE-Cadherin and eNOS, suggesting inhibition of EndMT in HeLa cells.

Conclusion

The traditional Chinese herbal combination modulates key metabolic pathways in vivo and inhibits EndMT in vitro, while reducing HeLa cell proliferation and migration. These findings highlight its potential as a therapeutic approach for managing HPV infections, bridging traditional practices with scientific research.
Chinese herbal medicine, Tongxieyaofang, alleviates diarrhea via gut microbiota remodeling: evidence from network pharmacology and full-length 16S rRNA gene sequencing
Authors: Shao Haoqing , Wang Liping , Zhang Hualing
Published: November 2024

Background

Tongxieyaofang (TXYF) was a traditional Chinese medicine (TCM) formula for the treatment of diarrhea with liver stagnation and spleen deficiency syndrome, but the potential targets and mechanisms have not been fully clarified. This study aims to explore the potential mechanisms of TXYF in alleviating diarrhea using network pharmacology and full-length 16S rRNA gene sequencing.

Methods

Network pharmacology was applied to identify bioactive compounds and potential targets involved in the role of TXYF in alleviating diarrhea. Meanwhile, a model of diarrhea with liver stagnation and spleen deficiency syndrome was constructed by intragastric administration of Folium senna extract combined with restraint and tail pinch stress. The effect of TXYF on intestinal mucosal microbiota of diarrhea mice was analyzed by full-length 16S rRNA gene sequencing.

Results

Network pharmacology analysis showed that kaempferol, wogonin, naringenin, and nobiletin were compounds associated with the efficacy of TXYF. TXYF may alleviate diarrhea via multiple BPs and pathways, including TNF signaling pathway, IL-17 signaling pathway, and Toll-like receptor signaling pathway, which are involved in TCM-gut microbiota-host interactions. Then, we found that TXYF administration reshaped the diversity and composition of the intestinal mucosal microbial community of diarrhea mice. Lactobacillus, primarily Lactobacillus johnsonii, was enriched by the administration of TXYF. After TXYF administration, the abundance of Lactobacillus, particularly Lactobacillus johnsonii, was enriched.

Conclusion

Oral administration of TXYF may alleviate diarrhea through remodeling intestinal mucosal microbiota. Promoting the colonization of beneficial commensal bacteria in the intestinal mucosa through gut microbiota-host interactions may be a potential mechanism of TXYF in the treatment of diarrhea.