bluuebunny/crossref_metadata_2025 huggingface dataset:
Biogeochemical context impacts seawater pH changes resulting from atmospheric sulfur and nitrogen deposition
Authors: Hagens Mathilde , Hunter Keith A. , Liss Peter S. , Middelburg Jack J.
Published: January 2014

Seawater acidification can be induced both by absorption of atmospheric carbon dioxide (CO2) and by atmospheric deposition of sulfur and nitrogen oxides and ammonia. Their relative significance, interplay, and dependency on water column biogeochemistry are not well understood. Using a simple biogeochemical model we show that the initial conditions of coastal systems are not only relevant for CO2‐induced acidification but also for additional acidification due to atmospheric acid deposition. Coastal areas undersaturated with respect to CO2 are most vulnerable to CO2‐induced acidification but are relatively least affected by additional atmospheric deposition‐induced acidification. In contrast, the pH of CO2‐supersaturated systems is most sensitive to atmospheric deposition. The projected increment in atmospheric CO2 by 2100 will increase the sensitivity of coastal systems to atmospheric deposition‐induced acidification by up to a factor 4, but the additional annual change in proton concentration is at most 28%.
Intensified land surface control on boundary layer growth in a changing climate
Authors: Dirmeyer Paul A. , Wang Zaiyu , Mbuh Mbongowo J. , Norton Holly E.
Published: January 2014

Data from the Coupled Model Intercomparison Project Phase 5 for historical and future climate scenarios are examined for changes in the energy cycle component of land surface feedback on the atmosphere, namely, through the linkages from soil moisture to sensible heat flux to the height of the lifting condensation level marking the cloud base. Climate models project heightened sensitivity in both of these segments of the feedback pathway over most of the globe. This is in agreement with studies showing similar increases in land‐atmosphere feedback through the water cycle, despite different physical processes, and may contribute to prevalent droughts and floods found in most climate change forecasts.
Morphology of asteroid (4179) Toutatis as imaged by Chang'E‐2 spacecraft
Authors: Zhu Meng‐Hua , Fa Wenzhe , Ip Wing‐Huen , Huang Jiangchuan , Liu Tiantian , Meng Linzhi , Yan Jun , Xu Aoao , Tang Zesheng , Wang Xiaolei , Qiao Dong
Published: January 2014

Close observations by the Chang'E‐2 spacecraft reveal that the surface of asteroid (4179) Toutatis is characterized by abundant impact craters with most of them being degraded by surface resetting. The less degraded large crater with a diameter of ~800 m at the south pole is estimated to be produced by an impactor with a diameter of ~50 m from strength crater scaling relations. From the analysis of large‐impact events on highly porous targets, we argue that Toutatis is likely a rubble‐pile body and its two lobes are contact binaries. The fact that Toutatis suffered plenty of impacts with seismic shaking resetting the initial surface features but not resulting in catastrophic disruption is probably because of the material's high attenuation of shock wave.
Global time‐dependent chorus maps from low‐Earth‐orbit electron precipitation and Van Allen Probes data
Authors: Chen Yue , Reeves Geoffrey D. , Friedel Reiner H. W. , Cunningham Gregory S.
Published: January 2014

Substorm injected electrons (several–100 s keV) produce whistler‐mode chorus waves that are thought to have a major impact on the radiation belts by causing both energization and loss of relativistic electrons in the outer belt. High‐altitude measurements, such as those from the Van Allen Probes, provide detailed wave measurements at a few points in the magnetosphere. But physics‐based models of radiation‐belt dynamics require knowledge of the global distribution of chorus waves. We demonstrate that time‐dependent, global distributions of near‐equatorial chorus wave intensities can be inferred from low‐Earth‐orbit (LEO) measurements of precipitating low‐energy electrons. We compare in situ observations of near‐equatorial chorus waves with LEO observations of precipitating electrons and derive a heuristic formula that relates, quantitatively, electron precipitation fluxes to chorus wave intensities. Finally, we demonstrate how that formula can be applied to LEO precipitation measurements and in situ Van Allen Probes wave measurements to provide global, data‐driven inputs for radiation belt models.
Regional impact of submarine canyons during seasonal upwelling
Authors: Connolly Thomas P. , Hickey Barbara M.
Published: January 2014

A numerical model of the northern California Current System along the coasts of Washington and British Columbia is used to quantify the impact of submarine canyons on upwelling from the continental slope onto the shelf. Comparisons with an extensive set of observations show that the model adequately represents the seasonal development of near‐bottom density, as well as along‐shelf currents that are critical in governing shelf‐slope exchange. Additional model runs with simplified coastlines and bathymetry are used to isolate the effects of submarine canyons. Near submarine canyons, equatorward flow over the outer shelf is correlated with dense water at canyon heads and subsequent formation of closed cyclonic eddies, which are both associated with cross‐shelf ageostrophic forces. Lagrangian particles tracked from the slope to midshelf show that canyons are associated with upwelling from depths of ∼140–260 m. Source depths for upwelling are shallower than 150 m at locations away from canyons and in a model run with bathymetry that is uniform in the along‐shelf direction. Water upwelled through canyons is more likely to be found near the bottom over the shelf. Onshore fluxes of relatively saline water through submarine canyons are large enough to increase volume‐averaged salinity over the shelf by 0.1–0.2 psu during the early part of the upwelling season. The nitrate input from the slope to the Washington shelf associated with canyons is estimated to be 30–60% of that upwelled to the euphotic zone by local wind‐driven upwelling.
Lightning discharges produced by wind turbines
Authors: Montanyà Joan , van der Velde Oscar , Williams Earle R.
Published: January 2014

New observations with a 3‐D Lightning Mapping Array and high‐speed video are presented and discussed. The first set of observations shows that under certain thunderstorm conditions, wind turbine blades can produce electric discharges at regular intervals of ~3 s in relation to its rotation, over periods of time that range from a few minutes up to hours. This periodic effect has not been observed in static towers indicating that the effect of rotation is playing a critical role. The repeated discharges can occur tens of kilometers away from electrically active thunderstorm areas and may or may not precede a fully developed upward lightning discharge from the turbine. Similar to rockets used for triggering lightning, the fast movement of the blade tip plays an important role on the initiation of the discharge. The movement of the rotor blades allows the tip to “runaway” from the generated corona charge. The second observation is an uncommon upward/downward flash triggered by a wind turbine. In that flash, a negative upward leader was initiated from a wind turbine without preceding lightning activity. The flash produced a negative cloud‐to‐ground stroke several kilometers from the initiation point. The third observation corresponds to a high‐speed video record showing simultaneous upward positive leaders from a group of wind turbines triggered by a preceding intracloud flash. The fact that multiple leaders develop simultaneously indicates a poor shielding effect among them. All these observations provide some special features on the initiation of lightning by nonstatic and complex tall structures.
Nonmigrating tidal heating and MLT tidal wind variability due to the El Niño–Southern Oscillation
Authors: Warner K. , Oberheide J.
Published: January 2014

Tides forced by large‐scale weather systems in the tropical troposphere introduce significant longitudinal and local time variability in the upper atmosphere. This paper presents variability of tidal harmonics of the latent heating from 2002 to 2011 associated with the El Niño–Southern Oscillation (ENSO) and the tidal wind response in the mesosphere/lower thermosphere (MLT) region. Emphasis is on the strong ENSO cycle 2009–2011. Latent tidal heating rates are computed from TRMM satellite precipitation data, with added radiative heating from MERRA reanalysis, as functions of time, latitude, and altitude. The heating rates for the two most affected nonmigrating tides (DE3 and DE2) are examined and compared with MLT tidal wind variability from TIDI/TIMED. Principal component analysis (PCA) is used to identify the tidal modes most affected by ENSO. Our results indicate that the tidal response to ENSO is largest during winter for both of the tides, with the largest response occurring in the DE3 tidal winds during the La Niña phase, with an increase of roughly 70% for the winter months of 2010/2011, and negligible response during the El Niño phase. The ENSO effect in the tidal forcing closely resembles the first symmetric and antisymmetric Hough modes of DE3 and DE2, thus being an efficient mechanism to transmit the ENSO signal into the MLT tides.
Tracking, Tagging and Scanning the City
Authors: Hudson‐Smith Andrew
Published: January 2014

The proliferation of social media and software, such as building information modelling (BIM), has led to an unprecedented accumulation of data in the last few years, which can be tracked, tagged and scanned.With it, buildings and cities have been transformed into portals for information. Andrew Hudson‐Smith, Director at the Centre for Advanced Spatial Analysis, University College London (UCL), describes how the ability to use emerging urban analytic tool kits provides the possibility of a real‐time view of the city and a crystal‐ball‐like glimpse into urban networks of the future.
Enantioselective Organocatalyzed Formal [4+2] Cycloaddition of Ketimines with Allenoates: Easy Access to a Tetrahydropyridine Framework with a Chiral Tetrasubstituted Stereogenic Carbon Center
Authors: Takizawa Shinobu , Arteaga Fernando Arteaga , Yoshida Yasushi , Suzuki Michitaka , Sasai Hiroaki
Published: January 2014

Enantioselective organocatalytic synthesis of tetrahydropyridines bearing a chiral tetrasubstituted carbon stereogenic center has been achieved. The spiro‐type monoaryl phosphine catalyst, (R)‐SITCP, was found to promote the formal [4+2] cycloaddition of saccharin‐derived ketimines and α‐methyl allenoate to afford the corresponding six‐membered N‐heterocycles in high yields and excellent regioselectivities with up to 93% ee.
Novel cyclohexyl‐based aminophosphine ligands and use of their Ru(II) complexes in transfer hydrogenation of ketones
Authors: Kayan Cezmi , Meriç Nermin , Aydemir Murat , Ocak Yusuf Selim , Baysal Ak𝚤n , Temel Hamdi
Published: January 2014

Two new aminophosphines – furfuryl‐(N‐dicyclohexylphosphino)amine, [Cy2PNHCH2–C4H3O] (1) and thiophene‐(N‐dicyclohexylphosphino)amine, [Cy2PNHCH2–C4H3S] (2) – were prepared by the reaction of chlorodicyclohexylphosphine with furfurylamine and thiophene‐2‐methylamine. Reaction of the aminophosphines with [Ru(η6‐p‐cymene)(μ‐Cl)Cl]2 or [Ru(η6‐benzene)(μ‐Cl)Cl]2 gave corresponding complexes [Ru(Cy2PNHCH2–C4H3O)(η6‐p‐cymene)Cl2] (1a), [Ru(Cy2PNHCH2–C4H3O)(η6‐benzene)Cl2] (1b), [Ru(Cy2PNHCH2–C4H3S)(η6‐p‐cymene)Cl2] (2a) and [Ru(Cy2PNHCH2–C4H3S)(η6‐benzene)Cl2] (2b), respectively, which are suitable catalyst precursors for the transfer hydrogenation of ketones. In particular, [Ru(Cy2PNHCH2–C4H3S)(η6‐benzene)Cl2] acts as a good catalyst, giving the corresponding alcohols in 98–99% yield in 30 min at 82 °C (up to time of flight ≤ 588 h−1). Copyright © 2014 John Wiley & Sons, Ltd.
Mechanism of an unusual, but clinically significant, digoxin–bupropion drug interaction
Authors: He Jiake , Yu Yang , Prasad Bhagwat , Chen Xijing , Unadkat Jashvant D.
Published: January 2014

An unusual, but clinically significant, digoxin (DIG)–bupropion (BUP) drug interaction (DDI), in which BUP increased DIG renal clearance by 80% is reported. To investigate the mechanism(s) of this unusual DDI, first the effect of BUP, its circulating metabolites or their combination on [3H]‐DIG transport by cells expressing human P‐gp or human OATP4C1 was determined. Second, the study asked whether this DDI could be replicated in the rat so that it could be used to conduct mechanistic studies. Then, the effect of BUP and its rat metabolites on [3H]‐DIG transport were tested by cells expressing rat Oatp4c1. Bupropion and its metabolites had no effect on human P‐gp mediated transepithelial transport of [3H]‐DIG. Bupropion and hydroxybupropion (HBUP) significantly stimulated H‐OATP4C1 mediated transport of [3H]‐DIG. In addition, BUP cocktail (BUP plus its metabolites) significantly increased the H‐OATP4C1 mediated transport of [3H]‐DIG, and partially reversed the inhibition by 100 µm DIG. However, erythro‐hydrobupropion (EBUP) and threo‐hydrobupropion (TBUP) did not affect the [3H]‐DIG uptake by H‐OATP4C1 cells. Bupropion administration significantly increased digoxin renal clearance in rats. Surprisingly, bupropion significantly inhibited r‐Oatp4c1 mediated transport of [3H]‐DIG at clinically relevant unbound plasma concentrations of BUP or those observed in the rat study, while HBUP or TBUP did not. These data support our hypothesis that at clinically relevant plasma concentrations, bupropion and its metabolites activate H‐OATP4C1 mediated DIG tubular secretion, and could possibly explain the increase in digoxin renal clearance produced by bupropion. While bupropion increased digoxin renal clearance in the rat, it appeared to do so by inhibiting r‐Oatp4c1‐mediated digoxin renal reabsorption. Copyright © 2014 John Wiley & Sons, Ltd.
Possible risks due to exposure of workers and patients with implants by TETRA transmitters
Authors: Cecil Stefan , Neubauer Georg , Rauscha Friedrich , Stix Günter , Müller Wolfgang , Breithuber Christian , Glanzer Markus
Published: January 2014

Several studies have demonstrated that mobile telephones that use different technologies, such as Global System for Mobile Communication (GSM) or Universal Mobile Telecommunication System (UMTS), have the potential to influence the functionality of active electronic implants, including cardiac pacemakers. According to these studies, a few safety measures, such as maintaining minimum distances of 25 cm between implants and transmitters, are sufficient to avoid such effects. Terrestrial Trunked Radio (TETRA) has become a well‐established communication standard in many countries, including Germany and Austria. TETRA transmitters are typically used by police forces and emergency services. Employees and volunteers working for such institutions are often in close contact with patients, causing TETRA transmitters to potentially have an impact on the functionality of the implants of patients. Therefore, the main focus of our study was to investigate the functionality of several types of implants when exposed to TETRA transmitters. Moreover, we investigated the difference in the degree of exposure of users of TETRA transmitters when they carry the devices in different locations near the body, and when they use them in different positions near the head. Our results show that a compliance distance of 30 cm between implant and transmitter is sufficient to exclude any influence on the examined implants. All examined exposure conditions demonstrated that the levels were well below recommended limits. If a user wants to minimize their exposure, use of transmitters in front of the mouth leads to somewhat lower exposure when compared to typical mobile phone like use. Bioelectromagnetics. 35:192–200, 2014. © 2014 Wiley Periodicals, Inc.
γ‐Al2O3‐Supported and Unsupported (Ni)MoS2for the Hydrodenitrogenation of Quinoline in the Presence of Dibenzothiophene
Authors: Hein Jennifer , Hrabar Ana , Jentys Andreas , Gutiérrez Oliver Y. , Lercher Johannes A.
Published: January 2014

Supported MoS2/γ‐Al2O3and Ni‐MoS2/γ‐Al2O3as well as unsupported Ni‐MoS2were investigated in the hydrodenitrogenation (HDN) of quinoline in the presence of dibenzothiophene (DBT). The supported oxide catalyst precursors had a well‐dispersed amorphous polymolybdate structure that led to the formation of a highly dispersed sulfide phase. In contrast, the unsupported catalyst precursor consisted of a mixture of nickel molybdate and ammonium nickel molybdate phases that formed stacked sulfide slabs after sulfidation. On all catalysts, the reaction pathway for the removal of N in quinoline HDN mainly followed the sequence quinoline→1,2,3,4‐tetrahydroquinoline→decahydroquinoline→propylcyclohexylamine→propylcyclohexene→propylcyclohexane. The hydrodesulfurization of DBT proceeded mainly by direct desulfurization towards biphenyl. For both processes, the activity increased in the order MoS2/γ‐Al2O3<Ni‐MoS2/unsupported<Ni‐MoS2/γ‐Al2O3. The promotion of the MoS2phase with Ni enhances the activity of the unsupported catalyst to a greater extent than the supported one. However, the multiply stacked unsupported Ni‐MoS2exhibited lower rates than Ni‐MoS2/γ‐Al2O3because of its lower dispersion.
Light‐Controlled Formation of Vesicles and Supramolecular Organogels by a Cholesterol‐Bearing Amphiphilic Molecular Switch
Authors: van Herpt Jochem T. , Areephong Jetsuda , Stuart Marc C. A. , Browne Wesley R. , Feringa Ben L.
Published: January 2014

A new responsive material composed of an amphiphilic light‐switchable dithienylethene unit functionalized with a hydrophobic cholesterol unit and a hydrophilic poly(ethylene glycol)‐modified pyridinium group has been designed. This unique single‐molecule system shows responsive light‐switchable self‐assembly in both water and organic solvents. Light‐triggered reversible vesicle formation in aqueous solutions is reported. The molecule shows a different behavior in apolar aromatic solvents, in which light‐controlled formation of organogel fibers is observed. The light‐triggered aggregation behavior of this molecule demonstrates that control of a supramolecular structure with light can be achieved in both aqueous and organic media and that this ability can be present in a single molecule. This opens the way toward the effective development of new strategies in soft nanotechnology for applications in controlled chemical release systems.
Effects of Quantum Nuclear Delocalisation on NMR Parameters from Path Integral Molecular Dynamics
Authors: Dračínský Martin , Hodgkinson Paul
Published: January 2014

The influence of nuclear delocalisation on NMR chemical shifts in molecular organic solids is explored using path integral molecular dynamics (PIMD) and density functional theory calculations of shielding tensors. Nuclear quantum effects are shown to explain previously observed systematic deviations in correlations between calculated and experimental chemical shifts, with particularly large PIMD‐induced changes (up to 23 ppm) observed for carbon atoms in methyl groups. The PIMD approach also enables isotope substitution effects on chemical shifts and J couplings to be predicted in excellent agreement with experiment for both isolated molecules and molecular crystals. An approach based on convoluting calculated shielding or coupling surfaces with probability distributions of selected bond distances and valence angles obtained from PIMD simulations is used to calculate isotope effects.
Synergistic Effects of Lewis Bases and Substituents on the Electronic Structure and Reactivity of Boryl Radicals
Authors: Lu Dongmei , Wu Chao , Li Pengfei
Published: January 2014

Boryl radicals have the potential for the development of new molecular entities and for application in new radical reactions. However, the effects of the substituents and coordinating Lewis bases on the reactivity of boryl radicals are not fully understood. By using first‐principles methods, we investigated the spin‐density distribution and reactivity of a series of boryl radicals with various substituents and Lewis bases. The substituents, along with the Lewis bases, only affect the radical reactivity when an unpaired electron is in the boron pz orbital, that is, for three‐coordinate radicals. We found evidence of synergistic effects between the substituents and the Lewis bases that can substantially broaden the tunability of the reactivity of the boryl radicals. Among Lewis bases, pyridine and imidazol‐2‐ylidene show a similar capacity for stabilization by delocalizing the spin density. Electron‐donating substituents, such as nitrogen, more efficiently stabilize boryl radicals than oxygen and carbon atoms. The reactivity of a boryl radical is always boron based, irrespective of the spin density on boron.
ChemInform Abstract: Phase Stability and Transport Mechanisms in Antiperovskite Li3OCI and Li3OBr Superionic Conductors
Authors: Emly Alexandra , Kioupakis Emmanouil , Van der Ven Anton
Published: January 2014

first principle calculations
ChemInform Abstract: Rare‐Earth Transition‐Metal Indium Sulfides RE3FeInS7 (RE: La—Pr), RE3CoInS7 (RE: La, Ce), and La3NiInS7.
Authors: Rudyk Brent W. , Stoyko Stanislav S. , Mar Arthur
Published: January 2014

The title compounds are prepared from stoichiometric mixtures of the elements (silica tubes, 1050 °C, 96 h) and characterized by powder and single crystal XRD, XPS, magnetic susceptibility measurements, and TB‐LMTO‐ASA band structure calculations.
ChemInform Abstract: A Novel Yellow‐Emitting SrAlSi4N7:Ce3+ Phosphor for Solid State Lighting: Synthesis, Electronic Structure and Photoluminescence Properties.
Authors: Ruan Jian , Xie Rong‐Jun , Funahashi Shiro , Tanaka Yoshinori , Takeda Takashi , Suehiro Takayuki , Hirosaki Naoto , Li Yuan‐Qiang
Published: January 2014

A series of Ce3+‐doped and Ce3+/Li+‐codoped SrAlSi4N7 phase‐pure phosphors are prepared by gas pressure sintering of stoichiometric powder mixtures of Sr3N2, AlN, α‐Si3N4, CeN, and Li3N with a double amount of AlN to avoid the formation of Sr2Si5N8 (1750 °C, 6 h, 0.92 MPa high purity N2).
ChemInform Abstract: Synthesis, Structure, Gas‐Phase Reactivity, and Catalytic Relevance of Trinuclear Mo3S4 Clusters Bearing Terminal Hydroxo and Hydrosulfido Groups.
Authors: Beltran Tomas F. , Feliz Marta , Llusar Rosa , Safont Vicent S. , Vicent Cristian
Published: January 2014

The crystal structures of compounds (III) and (IV) are determined by single crystal XRD.
ChemInform Abstract: An Unstable Paramagnetic Isopolyoxomolybdate Intermediate Non‐Homogeneously Reduced at Different Sites and Trapped in a Host Based on Chemical Adaptability.
Authors: Mueller Achim , et al. et al.
Published: January 2014

Compound (II) is characterized by IR, VIS/NIR, and EPR spectroscopy, XRD, and DFT calculations.
ChemInform Abstract: Synthesis and Crystal Structure of (1,3‐Diammoniumpropane)3 [V4W9O40]·H2O.
Authors: Hinz Michael , Naether Christian , Bensch Wolfgang
Published: January 2014

The new tungstovanadate (III) crystallizes in the monoclinic space group P21/m with Z = 2 (single crystal XRD).
ChemInform Abstract: New Layered Iron Sulfide NaFe1.6S2: Synthesis and Characterization.
Authors: Lai Xiaofang , Chen Xiaolong , Jin Shifeng , Wang Gang , Zhou Tingting , Ying Tianping , Zhang Han , Shen Shijie , Wang Wanyan
Published: January 2014

A series of compounds NaxFe2‐yS2+z (0.8 ≤ x ≤ 1; 0.3 ≤ y ≤ 0.6; 0 ≤ z ≤ 0.1) is prepared by solid state reaction of the elements (800 °C, 30—48 h).
ChemInform Abstract: Rhodium‐Catalyzed Intermolecular C—H Amination of Simple Hydrocarbons Using the Shelf‐Stable Nonafluorobutanesulfonyl Azide
Authors: Suarez Jose Ramon , Chiara Jose Luis
Published: January 2014

24 examples
ChemInform Abstract: Stereoselective Radical Azidooxygenation of Alkenes.
Authors: Zhang Bo , Studer Armido
Published: January 2014

A novel method for the radical azidooxygenation of alkenes is presented using TEMPONa and a hypervalent azidoiodine reagent.
ChemInform Abstract: Dinuclear Zinc—ProPhenol‐Catalyzed Enantioselective α‐Hydroxyacetate Aldol Reaction with Activated Ester Equivalents.
Authors: Trost Barry M. , Michaelis David J. , Truica Mihai I.
Published: January 2014

A dinuclear phenol zinc complex for the asymmetric aldol condensation of α‐hydroxyacetamide (I) is developed.
ChemInform Abstract: An Efficient Four‐Component Synthesis of Dithiocarbamate Derivatives.
Authors: Azizi Najmedin , Khajeh Meysam , Hasani Morteza , Dezfooli Sahar
Published: January 2014

An environmentally benign, one‐pot, four‐component synthesis of dithiocarbamate derivatives is reported.
ChemInform Abstract: C—H Functionalization of Cyclopropanes: A Practical Approach Employing a Picolinamide Auxiliary.
Authors: Roman Daniela Sustac , Charette Andre B.
Published: January 2014

The Pd‐catalyzed C—H arylation of picolinamide‐functionalized cyclopropanes is promoted by either a silver additive or catalytic amounts of pivalic acid in the presence of a carbonate base.
ChemInform Abstract: Carboxylate Assistance for Catalyzed Hydroarylations of Methylenecyclopropanes.
Authors: Schinkel Marvin , Wallbaum Jan , Kozhushkov Sergei I. , Marek Ilan , Ackermann Lutz
Published: January 2014

The use of ruthenium carboxylates as catalysts allows a carboxylate‐assisted chemoselective hydroarylation of strained methylenecyclopropanes with conservation of the cyclopropane ring.
ChemInform Abstract: Synthesis of Polyfluoroalkyl Cyclobutenes from 3‐Aza‐1,5‐enynes via an Aza‐Claisen Rearrangement/Cyclization Cascade.
Authors: Xin Xiaoyi , Wang Dongping , Wu Fan , Wang Chunxiang , Wang Haolong , Li Xincheng , Wan Boshun
Published: January 2014

Heating 3‐aza‐1,5‐enynes in dioxane leads to the formation of an allene‐imine intermediate via aza‐Claisen rearrangement.
ChemInform Abstract: Catalytic Enantioselective Amadori—Heyns Rearrangement of Racemic α‐Hydroxy Ketones with Arylamines: Synthesis of Optically Active α‐Arylamino Ketones.
Authors: Frongia Angelo , Secci Francesco , Capitta Francesca , Piras Pier Paolo , Sanna Maria Luisa
Published: January 2014

Title compounds [(III), (V), and (VIII)] are synthesized in good yields and good enantioselectivities.
ChemInform Abstract: Palladium‐Catalyzed anti‐Markovnikov Hydroalkylation of Homoallylic Alcohols Bearing β‐Fluorines.
Authors: Lin Xiaowei , Qing Feng‐Ling
Published: January 2014

Optimized reaction conditions allow the regioselective hydroalkylation of homoallylic alcohols, ethers, and amines with alkylzinc reagents to give the corresponding anti‐Markovnikov products.
ChemInform Abstract: TEMPO‐Catalyzed Aerobic Oxygenation and Nitrogenation of Olefins via C=C Double‐Bond Cleavage.
Authors: Wang Teng , Jiao Ning
Published: January 2014

The new method employs molecular oxygen as the terminal oxidant and oxygen‐atom source and occurs under metal‐free catalysis and mild conditions.
ChemInform Abstract: Gold‐Catalyzed Intramolecular Oxidation of Terminal Alkynes: Simple and Efficient Synthesis of α‐Mesyloxy Ketones.
Authors: Xie Longyong , Liang Zhiwu , Yan Dong , He Weimin , Xiang Jiannan
Published: January 2014

The title reaction is proposed to proceed via α‐oxo gold carbene intermolecular O—H insertion.
ChemInform Abstract: Direct Conversion of N‐Alkoxyamides to Carboxylic Esters Through Tandem NBS‐Mediated Oxidative Homocoupling and Thermal Denitrogenation.
Authors: Zhang Ningning , Yang Rui , Zhang‐Negrerie Daisy , Du Yunfei , Zhao Kang
Published: January 2014

This method is suitable for the synthesis of sterically hindered carboxylic esters.
ChemInform Abstract: Cinchona‐Based Squaramide‐Catalyzed Cascade Aza‐Michael—Michael Addition: Enantioselective Construction of Functionalized Spirooxindole Tetrahydroquinolines.
Authors: Yang Wen , Du Da‐Ming
Published: January 2014

Title compounds [(III), (V) and (VII)] are efficiently synthesized with excellent diastereoselectivities (<25:1 d.r.) and high enantioselectivities using a chiral bifunctional tertiary amine‐squaramide catalyst.
ChemInform Abstract: Palladium(II)‐Catalyzed Synthesis of 2H,3′H‐Spiro[benzofuran‐3,2′‐naphthoquinones].
Authors: Claes Pieter , Jacobs Jan , Kesteleyn Bart , Nguyen Van Tuyen , De Kimpe Norbert
Published: January 2014

Novel spiroheterocycles are prepared by an unprecedented Pd‐catalyzed spirocyclization.
ChemInform Abstract: Oxazolidine Sulfur Ylides Derived from Phenylglycinol for the Specific and Highly Diastereoselective Synthesis of Aryl and Alkyl trans‐Epoxyamides.
Authors: Gordillo Paola G. , Aparicio David M. , Flores Marcos , Mendoza Angel , Orea Laura , Juarez Jorge R. , Huelgas Gabriela , Gnecco Dino , Teran Joel L.
Published: January 2014

Coupling of chiral sulfur ylides of type (VII) with aldehydes provides an efficient and highly diastereoselective approach to aryl and alkyl trans‐epoxyamides.
ChemInform Abstract: Novel Synthesis of 3‐Aryl‐4‐hydroxybenzofurans via Four‐Component Reaction from Substituted Nitrostyrenes, Aromatic Aldehydes, Cyclohexan‐1,3‐diones, and Ammonium Acetate.
Authors: Li Yan , Liu Hui , Sun Liang , Liu Juanjuan , Xue Zhiheng , Yao Juan , Wang Cunde
Published: January 2014

A four‐component synthesis of functionalized 4‐hydroxybenzofurans is developed using nitrostyrenes, aromatic aldehydes, cyclohexane‐1,3‐diones and ammonium acetate as the reactants.
ChemInform Abstract: A Direct and General Method for the Reductive Alkylation of Tertiary Lactams/Amides: Application to the Step Economical Synthesis of Alkaloid (‐)‐Morusimic Acid D.
Authors: Xiao Kai‐Jiong , Wang Yu , Huang Ying‐Hong , Wang Xiao‐Gang , Huang Pei Qiang
Published: January 2014

A full account on previously published studies as well as their application to an improved synthesis of title compound (IX) is presented.
ChemInform Abstract: Palladium Catalyzed Cyclizations of Oxime Esters with 1,2‐Disubstituted Alkenes: Synthesis of Dihydropyrroles.
Authors: Race Nicholas J. , Bower John F.
Published: January 2014

The Pd‐catalyzed cyclization of pentafluorobenzoyl oximes is studied, resulting in the formation of vinyl substituted dihydropyrroles.
ChemInform Abstract: Conversion of Cyclic Ketones to 2,3‐Fused Pyrroles and Substituted Indoles.
Authors: Alford Joshua S. , Spangler Jillian E. , Davies Huw M. L.
Published: January 2014

The new synthesis of 2,3‐fused pyrroles from alkenyl‐1‐sulfonyltriazoles is achieved by a rhodium‐catalyzed 4π‐electrocyclization.
ChemInform Abstract: Chiral Phosphoric Acid‐Catalyzed Oxidative Kinetic Resolution of Indolines Based on Transfer Hydrogenation to Imines.
Authors: Saito Kodai , Shibata Yukihiro , Yamanaka Masahiro , Akiyama Takahiko
Published: January 2014

This new method proceeding via hydrogen transfer to imines by means of a chiral phosphoric acid catalyst is applicable to both 2‐aryl and 2‐alkyl substituted indolines.
ChemInform Abstract: Csp2—N Bond Formation via Ligand‐Free Pd‐Catalyzed Oxidative Coupling Reaction of N‐Tosylhydrazones and Indole Derivatives.
Authors: Roche Maxime , Frison Gilles , Brion Jean‐Daniel , Provot Olivier , Hamze Abdallah , Alami Mouad
Published: January 2014

The new method for the synthesis of substituted N‐vinylazoles shows a broad functional group tolerance.
ChemInform Abstract: Asymmetric Synthesis of 3‐Spirocyclopropyl‐2‐oxindoles via Intramolecular Trapping of Chiral Aza‐ortho‐xylylene
Authors: Dou Xiaowei , Yao Weijun , Zhou Bo , Lu Yixin
Published: January 2014

16 examples
ChemInform Abstract: Direct Olefination at the C‐4 Position of Tryptophan via C—H Activation: Application to Biomimetic Synthesis of Clavicipitic Acid.
Authors: Liu Qiang , Li Qingjiang , Ma Yongfan , Jia Yanxing
Published: January 2014

The reaction proceeds under mild conditions with various substituted olefins to give the corresponding 4‐substituted tryptophans.
ChemInform Abstract: Palladium‐Catalyzed Intramolecular Cyclization of 2‐Iodobenzamides: An Efficient Synthesis of 3‐Acyl Isoindolin‐1‐ones and 3‐Hydroxy‐3‐acylisoindolin‐1‐ones.
Authors: Chen Wanli , Jin Lina , Zhu Yinghong , Cao Xiaoji , Zheng Lebin , Mo Weimin
Published: January 2014

An efficient Pd‐catalyzed cyclization of ortho‐iodobenzamides (I) is developed to give 3‐acylated isoindolin‐2‐ones (II) in moderate to good yields.
ChemInform Abstract: Gold and BINOL‐Phosphoric Acid Catalyzed Enantioselective Hydroamination/N‐Sulfonyliminium Cyclization Cascade.
Authors: Gregory Alex W. , Jakubec Pavol , Turner Paul , Dixon Darren J.
Published: January 2014

An initial 5‐exo‐dig hydroamination followed by phosphoric acid catalyzed cyclization process provide access to complex sulfonamide scaffolds (II) in good yield and high enantiocontrol.
ChemInform Abstract: A Tandem [3 + 2] Cycloaddition—Elimination Cascade Reaction to Generate Pyrrolo‐[3,4‐c]pyrrole‐1,3‐diones.
Authors: Martinez‐Ariza Guillermo , Dietrich Justin , De Moliner Fabio , Hulme Christopher
Published: January 2014

A novel one‐pot 1,3‐dipolar cycloaddition‐elimination sequence allows the synthesis of the title compounds (III) from readily available pyrrole‐2,5‐diones and oxazolin‐2‐ones.
ChemInform Abstract: A Straightforward Synthesis of Indazolo[3,2‐a]isoquinolin‐6‐amines.
Authors: Balog Jozsef , Riedl Zsuzsanna , Hajos Gyoergy
Published: January 2014

A Cadogan reductive cyclization procedure under microwave irradiation gives intensively fluorescent title compounds (II).
ChemInform Abstract: Facile Synthesis of 2‐Arylbenzimidazoles by Nano‐CuY Zeolite as an Efficient and Eco‐Friendly Nanocatalyst.
Authors: Kalhor Mehdi , Khodaparast Nooshin , Zendehdel Mojgan
Published: January 2014

The title compounds are obtained by an one‐pot condensation reaction of o‐phenylenediamine and various aromatic aldehydes.
ChemInform Abstract: Iodine(III)‐Mediated [3 + 2] Cyclization for One‐Pot Synthesis of Benzo[d]isoxazole‐4,7‐diols in Aqueous Medium.
Authors: Hou Yingwei , Lu Shichao , Liu Gang
Published: January 2014

The preparation of the title compounds proceeds via in situ generation of benzoquinones and nitrile oxides.
ChemInform Abstract: Synthesis of Chromeno[2,3‐d]imidazol‐9(1H)‐ones via Tandem Reactions of 3‐Iodochromones with Amidines Involving Copper‐Catalyzed C—H Functionalization and C—O Bond Formation.
Authors: Sheng Jia , Chao Bo , Chen Hong , Hu Youhong
Published: January 2014

The title synthesis involves the initial formation of imidazolyl substituted acyl phenols which undergo a copper‐catalyzed C—H‐activation/C—O bond formation process.
ChemInform Abstract: Sequential Oxidation—Prins Reaction Processes Induced by the Same Iron Salt: Direct Access to 2‐Aryl‐4‐chloro‐tetrahydropyrans from Benzyl Alcohols.
Authors: Fache Fabienne , Muselli Mickael , Piva Olivier
Published: January 2014

Iron nitrate supported on bentonite K10 is used to oxidize benzylic alcohols to the corresponding aldehydes.
ChemInform Abstract: Color‐Tunable Fluorescent Dyes Based on Benzo[c]coumarin.
Authors: Krzeszewski Maciej , Vakuliuk Olena , Gryko Daniel T.
Published: January 2014

Several fluorophores are synthesized via the Hurtley‐condensation.
ChemInform Abstract: ortho‐(Dimesitylboryl)phenylphosphines: Positive Boryl Effect in the Palladium‐Catalyzed Suzuki—Miyaura Coupling of 2‐Chloropyridines.
Authors: Malacea Raluca , Chahdoura Faouzi , Devillard Marc , Saffon Nathalie , Gomez Montserrat , Bourissou Didier
Published: January 2014

The presence of ortho‐dimesitylboryl moiety in the catalyst is crucial to enhance the catalytic performance.
ChemInform Abstract: The Oxidation of Pyridines Catalyzed by Surfactant‐Encapsulated Polyoxometalate [(C18H37)2(CH3)2N] 8[HBW11O39] with the Temperature‐Responsive Property of Solubility.
Authors: Zhao Wei , Yang Chunxia , Ding Yong , Ma Baochun
Published: January 2014

The green and efficient catalytic system can be recovered and reused several times.
ChemInform Abstract: meso‐Pyridyl BODIPYs with Tunable Chemical, Optical and Electrochemical Properties.
Authors: Bartelmess Juergen , Weare Walter W. , Latortue Narah , Duong Christina , Jones Daniel S.
Published: January 2014

The title compounds (III) can be applied as fluorescent pH sensors in a pH range from ca. 1 to 4.
ChemInform Abstract: Silver Triflate‐Palladium Chloride Cooperative Catalysis in a Tandem Reaction for the Synthesis of H‐Pyrazolo[5,1‐a]isoquinolines.
Authors: Xiao Qing , Sheng Jie , Ding Qiuping , Wu Jie
Published: January 2014

A wide range of target compounds is prepared in good yields.
ChemInform Abstract: An Approach to the Synthesis of Tetrahydroisoquinoline Alkaloids by Alkene Hydroamination: Synthesis of Coralydine.
Authors: Pouilhes Annie , Baltaze Jean‐Pierre , Kouklovsky Cyrille
Published: January 2014

Intramolecular hydroamination of compound (I) offers an efficient access to coralydine (IV) and its epimer O‐methylcorytenchirine (V).
ChemInform Abstract: Regioselective Synthesis of 6‐Substituted‐2‐amino‐5‐bromo‐4(3H)‐pyrimidinones and Evaluation of Their Antiviral Activity.
Authors: Singh Kamaljit , Singh Kawaljit , Balzarini Jan
Published: January 2014

The synthesis of the title compounds uses a highly regioselective lithiation‐substitution protocol employing different types of electrophiles.
ChemInform Abstract: Synthesis and Properties of Imidazolo‐Fused Benzotriazinyl Radicals.
Authors: Berezin Andrey A. , Constantinides Christos P. , Mirallai Styliana I. , Manoli Maria , Cao Levy L. , Rawson Jeremy M. , Koutentis Panayiotis A.
Published: January 2014

A two‐step synthesis of title radicals (IV) is elaborated using a base‐promoted reaction of benzotriazinone (I) with benzamidines (II) followed by cyclization of resulting benzimidamides (III) in acetic acid.
ChemInform Abstract: Facile and Efficient Lewis Acid Catalyzed Synthesis of an Asymmetric Tetrazine Useful for Bio‐Orthogonal Click Chemistry Applications.
Authors: Alge Daniel L. , Donohue Dillon F. , Anseth Kristi S.
Published: January 2014

The reported simple two‐step method for the synthesis of tetrazine (V) is a significant improvement over previously reported methods.
ChemInform Abstract: Cu‐Catalyzed Asymmetric Borylative Cyclization of Cyclohexadienone‐Containing 1,6‐Enynes.
Authors: Liu Ping , Fukui Yuki , Tian Ping , He Zhi‐Tao , Sun Cai‐Yun , Wu Nuo‐Yi , Lin Guo‐Qiang
Published: January 2014

First time, the title reaction is achieved through a tandem process involving selective β‐borylation of propargylic ether and subsequent conjugate addition to cyclohexadienone.
ChemInform Abstract: Redox‐Neutral α‐C—H Bond Functionalization of Secondary Amines with Concurrent C—P Bond Formation/N‐Alkylation.
Authors: Das Deepankar , Seidel Daniel
Published: January 2014

Redox‐neutral formation of C—P bonds in the α‐position of amines is achieved via a process that features a combination of an oxidative α‐C—H bond functionalization and a reductive N‐alkylation.
ChemInform Abstract: Stereoselective Synthesis of Dienyl Phosphonates via Extended Tethered Ring‐Closing Metathesis.
Authors: Schmidt Bernd , Kunz Oliver
Published: January 2014

Grubbs ring‐closing metathesis of readily synthesized allyl phosphonates (II) produces (1Z,3E)‐dienes (IV).
ChemInform Abstract: Phosphoryl‐Related Directing Groups in Rhodium(III) Catalysis: A General Strategy to Diverse P‐Containing Frameworks.
Authors: Zhao Dongbing , Nimphius Corinna , Lindale Matthew , Glorius Frank
Published: January 2014

Arylphosphonates and phosphonamides are functionalized at the ortho position via Rh‐catalyzed oxidative C—H activation and subsequent coupling with alkenes, arenes, and alkynes.
ChemInform Abstract: Unprecedented Synthesis of Alkynylphosphine‐Boranes Through Room‐Temperature Oxidative Alkynylation.
Authors: Jouvin Kevin , Veillard Romain , Theunissen Cedric , Alayrac Carole , Gaumont Annie‐Claude , Evano Gwilherm
Published: January 2014

Oxidative alkynylation of phosphine‐boranes with alkynylcopper reagents allows a practical synthesis of alkynylphosphine‐boranes.
ChemInform Abstract: One‐Pot Synthesis of Ferrocenyl Ketones Containing Biaryls and 6‐Aryl‐2‐ferrocenylquinolines via Ir/Pd‐Cocatalyzed α‐Alkylation/Suzuki Reaction.
Authors: Xu Chen , Hao Xin‐Qi , Xiao Zhi‐Qiang , Wang Zhi‐Qiang , Yuan Xiao‐Er , Fu Wei‐Jun , Ji Bao‐Ming , Song Mao‐Ping
Published: January 2014

These efficient methods use simple reaction conditions and tolerate a variety of functional groups.
ChemInform Abstract: Total Synthesis of Cyanthiwigins A, C, G, and H.
Authors: Wang Cheng , Wang Dan , Gao Shuanhu
Published: January 2014

The core structure for the first total synthesis of cyanthiwigins A, C, H and G is obtained by formal [4 + 2] cycloaddition, stereospecific 1,4‐addition, alkylation, and ring‐closing metathesis.
ChemInform Abstract: Scopariusic Acid, a New Meroditerpenoid with a Unique Cyclobutane Ring Isolated from Isodon scoparius.
Authors: Pu Jian‐Xin , et al. et al.
Published: January 2014

Scopariusic acid (I) is isolated from the title plant together with compound (II).
ChemInform Abstract: Synthesis of 2‐Nitroglycals from Glycals Using the Tetrabutylammonium Nitrate—Trifluoroacetic Anhydride—Triethylamine Reagent System and Base‐Catalyzed Ferrier Rearrangement of Acetylated 2‐Nitroglycals.
Authors: Dharuman Suresh , Gupta Preeti , Kancharla Pavan K. , Vankar Yashwant D.
Published: January 2014

The new reagent system is used for the synthesis of 2‐nitroglycals from various protected glycals and can also be applied to non‐carbohydrate olefins.
ChemInform Abstract: Synthesis and Biophysical Properties of Constrained D‐Altritol Nucleic Acids (cANA).
Authors: Migawa Michael T. , Prakash Thazha P. , Vasquez Guillermo , Seth Punit P. , Swayze Eric E.
Published: January 2014

Constrained altritol nucleotide derivatives (I) are incorporated into antisense oligonucleotides (ASO) in order to study how conformationally restricting the D‐altritol backbone‐containing ASO will affect their ability to form duplexes with RNA.
ChemInform Abstract: Total Synthesis of Geralcin A, a Representative of a New Family of Hydrazine‐Containing Natural Product.
Authors: Le Goff Geraldine , Roulland Emmanuel , Ouazzani Jamal
Published: January 2014

The first total synthesis of geralcin A (I), a naturally occurring α,β‐unsaturated γ‐lactonohydrazide produced by Streptomyces sp.
ChemInform Abstract: Synthesis of 4‐Benzyl‐3‐phenylbutenolide Natural Products.
Authors: Parker Anna N. , Lock Matthew J. , Hutchison John M.
Published: January 2014

The first total synthesis of eutypoid A (Ia) and new syntheses of gymnoascolide A (Ib) and of racemic microperfuranone (II) are reported.
ChemInform Abstract: Structures of Spiroindicumides A and B, Unprecedented Carbon Skeletal Spirolactones, and Determination of the Absolute Configuration by Vibrational Circular Dichroism Exciton Approach.
Authors: Asai Teigo , Taniguchi Tohru , Yamamoto Takashi , Monde Kenji , Oshima Yoshiteru
Published: January 2014

Spiroindicumides A (Ia) and B (Ib), novel spirolactone polyketides, are isolated from a filamentous fungus, Chaetomium indicum, cultivated in the presence of a histone deacetylase inhibitor.
ChemInform Abstract: First Total Synthesis of Hunanamycin A
Authors: Shingare Rahul D. , Velayudham R. , Gawade Jalindar , Reddy Srinivasa
Published: January 2014

an antibiotic natural product from a marine‐derived Bacillus hunanensis
ChemInform Abstract: Preparation and Doping Mode of Doped LiMn2O4 for Li‐Ion Batteries
Authors: Liu Qiuling , Wang Shengping , Tan Haibo , Yang Zhigao , Zeng Jian
Published: January 2014

Review: 94 refs.
ChemInform Abstract: Chemistry of Boron Hydrides Orchestrated by Dihydrogen Bonds
Authors: Filippov Oleg A. , Belkova Natalia V. , Epstein Lina M. , Shubina Elena S.
Published: January 2014

Review: 86 refs.
ChemInform Abstract: Low‐Temperature Plasma Synthesis of Carbon Nanotubes and Graphene Based Materials and Their Fuel Cell Applications
Authors: Wang Qi , Wang Xiangke , Chai Zhifang , Hu Wenping
Published: January 2014

Review: [50 refs.]
ChemInform Abstract: Rare Earth Tungstate and Molybdate Compounds — From 0D to 3D Architectures
Authors: Kaczmarek Anna M. , Van Deun Rik
Published: January 2014

Review: synthetic approaches and chemical tuning of the size, shape, and morphology, as well as properties such as luminescence; 52 refs.
ChemInform Abstract: Carborane‐Based Transition Metal Complexes and Their Catalytic Applications for Olefin Polymerization: Current and Future Perspectives
Authors: Yinghuai Zhu , Hosmane Narayan S.
Published: January 2014

Review: 34 refs.
ChemInform Abstract: Molecularly designed Architectures — The Metalloligand Way
Authors: Kumar Girijesh , Gupta Rajeev
Published: January 2014

Review: 316 refs.
ChemInform Abstract: Synthetic Methods. Part 2. Oxidation and Reduction Methods
Authors: Gee Yi Sing , Abd El Kader Kamelia Fathy , Hyland Christopher J. T.
Published: January 2014

Review: advances in some of the most commonly used oxidation and reduction reactions pblished in the literature from 2012; 132 refs.
ChemInform Abstract: Recent Advances in the Chemoselective Reduction of Functional Groups Mediated by Samarium(II) Iodide: A Single Electron Transfer Approach
Authors: Szostak Michal , Spain Malcolm , Procter David J.
Published: January 2014

Review: <200 refs.
ChemInform Abstract: Z Selectivity: Recent Advances in One of the Current Major Challenges of Olefin Metathesis
Authors: Shahane Saurabh , Bruneau Christian , Fischmeister Cedric
Published: January 2014

Review: <150 refs.
ChemInform Abstract: A New Remote Control for Traceless meta‐C—H Olefination of Phenols
Authors: Martinez Claudio , Muniz Kilian
Published: January 2014

Review: 16 refs.
ChemInform Abstract: Science‐Intensive Utilization of Environmentally Harmful Polychlorocarbons. Synthesis of Biologically Active Cyclopentanoids from Hexachlorocyclopentadiene
Authors: Tolstikov G. A. , Ismailov S. A. , Gimalova F. A. , Ivanova N. A. , Miftakhov M. S.
Published: January 2014

Review: 26 refs.
ChemInform Abstract: Advances in Nucleophilic Phosphine Catalysis of Alkenes, Allenes, Alkynes, and MBHADs
Authors: Fan Yi Chiao , Kwon Ohyun
Published: January 2014

Review: 138 refs.
ChemInform Abstract: The Birth of Protein Electrochemistry
Authors: Blanford Christopher F.
Published: January 2014

Review: 51 refs.
ChemInform Abstract: Biologically Active Polymer Systems Based on Hemoglobin
Authors: Kuznetsova N. P. , Panarin E. F. , Gudkin L. R. , Mishaeva R. N.
Published: January 2014

Review: 144 refs.
ChemInform Abstract: 25th Anniversary Article: A Decade of Organic/Polymeric Photovoltaic Research
Authors: Dou Letian , You Jingbi , Hong Ziruo , Xu Zheng , Li Gang , Street Robert A. , Yang Yang
Published: January 2014

Review: 292 refs.
ChemInform Abstract: Methane as Raw Material in Synthetic Chemistry: The Final Frontier
Authors: Caballero Ana , Perez Pedro J.
Published: January 2014

Review: different methodologies to activate methane with transition metal complexes as well as few examples of the catalytic functionalization of methane; 60 refs.
ChemInform Abstract: Flow Chemistry Syntheses of Natural Products
Authors: Pastre Julio C. , Browne Duncan L. , Ley Steven V.
Published: January 2014

Review: 130 refs.
ChemInform Abstract: Polymers for Electronics and Spintronics
Authors: Bujak Piotr , Kulszewicz‐Bajer Irena , Zagorska Malgorzata , Maurel Vincent , Wielgus Ireneusz , Pron Adam
Published: January 2014

Review: <550 refs.
ChemInform Abstract: Efficient and Safe Medicines Developed by Siberian Scientists
Authors: Lyakhov N. Z. , Dushkin A. V. , Tolstikova T. G.
Published: January 2014

Review: 30 refs.
(−)‐R‐Mevalonolactone Studied by ROA and SERS Spectroscopy
Authors: Chruszcz‐Lipska Katarzyna , Jaworska Aleksandra , Szczurek Ewelina , Baranska Malgorzata
Published: January 2014

Here we present for the first time the experimental and theoretical (DFT/B3LYP/6‐311++G**) Raman optical activity (ROA) spectra of (−)‐R‐mevalonic acid as the δ‐lactone form in neat liquid and in the aqueous solution. Quantum chemical calculations show the conformational diversity of (−)‐R‐mevalonolactone originated from small energy differences between the various conformation of the six‐membered ring and the arrangement of the hydroxyl group. According to calculations, the investigated compound takes predominantly the chair conformation with the hydroxyl group in axial position, but the contribution of the other chair and boat conformers in the equilibrium at room temperature is not negligible. Additionally, we present normal Raman and the surface enhanced Raman (SERS) spectra of (−)‐R‐mevalonolactone adsorbed on the colloidal silver. Chirality 26:453–461, 2014. © 2014 Wiley Periodicals, Inc.