bluuebunny/crossref_metadata_2025 huggingface dataset:
ANALISIS NILAI-NILAI EDUKATIF PADA NOVEL AYAH KARYA ANDREA HIRATA
Authors: Sari Nila
Published: January 2022

This study aims to find out reviews about the novel and educative values on the novel of Ayah by Andrea Hirata. This research is a qualitative study using descriptive methods. The data source of this research is in the form of a journal related to research on novels and novels of Ayah by Andrea Hirata, amounting to 412 pages. Data collection techniques using listening and note taking techniques. Data validation techniques using data triangulation. Data analysis uses data reduction, data display and conclusion drawing. The results of this study indicate that there are educative values in Andrea Hirata Ayah novel that can provide benefits in social life and can be applied to life learning. The educational values contained in the novel are religious values, moral values, social values and cultural values
ANALISIS KESALAHAN STRUKTUR DAN PEMAKAIAN BAHASA INDONESIA PADA TEKS PERSUASI KARANGAN SISWA KELAS 8 SMP DI SURAKARTA
Authors: Subekti Nesa Amelia , Sumarwati Sumarwati , Suhita Raheni
Published: January 2022

The results shows that there are structure error and Indonesian language usage error on the persuasion text written by students at grade 8 of Junior High School in Surakarta. Those errors on the incomplete structure of persuasion text especially in the reaffirmation section. The Indonesian language usage errors include spelling error, diction error, and grammatical error. The most common errors of spelling comprises capital letters and punctuation marks usage particularly full stop and comma. The most-found errors of diction comprises improper diction selection and nonstandard diction. Grammatical error is mainly caused by ineffective sentence. Those errors are caused by some factors. The factors are (1) students do not understand the structure of persuasion text, (2) students have lack of spelling and diction knowledge, (3) the lack of examples given by teacher, (4) the lack of writing practice, and (5) student lack motivation within writing.
MUATAN PENDIDIKAN KARAKTER DALAM CERITA PENDEK DI BUKU PELAJARAN BAHASA INDONESIA SMA
Authors: Sufanti Main , Oktaviani Anis , Cahyati Jeni Nur , Sholeh Khabib
Published: January 2022

This study aims to (1) Describe short stories published in Indonesian textbooks for high school. (2) Describe the content of character education in short stories in Indonesian textbooks for high school. This research is a qualitative descriptive study. Data in this study are words, sentences and paragraphs in short stories in Indonesian textbooks for high school. Data sources in this study are Indonesian language textbooks for high schools which are still used in high school, both based on the 2006 curriculum and based on the 2013 curriculum. Data collection techniques used in this study are intensive reading and recording techniques. Data analysis techniques with heuristic and hermeunitic techniques. The results of this study are as follows. (1) The study found 18 lessons in Indonesian language studies, 3 books that did not include a pen, and 15 books included a pen. In 15 lessons found 27 short stories. (2) Short stories in sufficient learning have the potential for 12 educational values of religious character, responsibility, social scrutiny, love, honesty, hard work, tolerance, nationalism, water love, friendship, democracy, and curiosity. The most frequently occurring educational values of character are religious, responsibility, social scrutiny, and love.
 
TINDAK TUTUR RIDWAN REMIN PADA STAND UP COMEDY INDONESIA SEASON 7 KOMPAS TV EDISI JUNI 2017
Authors: Jasnain Tilsep
Published: January 2022

The problem of this research is what are Ridwan Remin's speech acts in the June 2017 edition of Stand Up Comedy Indonesia, Kompas TV. The purpose of this study is to find out and describe Ridwan Remin's speech acts in his appearance in Stand Up Comedy which specializes in locus speech acts, illocution and perlocution. The method used in this research is descriptive qualitative method. The data source and the object of the research were the videos of Ridwan Remin's Stand Up Comedy performance at the Stand Up Comedy Indonesia season 7, Kompas TV June 2017 edition, consisting of 5 videos. Data analysis techniques are using documentation techniques. The analysis results obtained are in the form of 20 sentences of speech action locus, 10 sentences of speech acts of illocution, and 3 sentences of speech acts of perlocution. In speech, of course, speech acts are needed so that the meaning in the speech can be conveyed to the speech partner so that it can cause a reaction or reciprocal relationship for the speaker.
STUDI KESALAHAN PEMAKAIAN EJAAN DAN STRUKTUR KARANGAN EKSPLANASI SISWA KELAS VIII SMP NEGERI 1 BANYUDONO
Authors: Susanti Dani Dwi , Andayani Andayani , Suryanto Edy
Published: January 2022

This research is a case study using descriptive qualitative methods with 21 research subjects explanatory essays written by class VIII students. The results showed that (1) there were 447 findings of spelling errors, including the writing of absorption elements (0.06%), word writing (8.27%), use of punctuation marks (18.34%), and use of letters (72, 70%) dominated by capital letters errors (70.69%) in the form of findings of patterns of capital letters errors; (2) there are seven articles that have structural errors, including the structure of the composition which is not coherent, the ambiguous type of the article, and the fact that incomplete of the structure dominates the findings of structural errors and becomes one of the triggers for other errors; (3) the factors causing the error are lack of writing practice, less thoroughness, lack of understanding of students, students' language habits, and lack of student interest in following lessons which are the dominant factors because it exacerbates other factors; (4) preventive action, students choose to learn to use spelling correctly and write explanatory text; the teacher makes direct corrections, emphasizes punishment, the use of spelling guidelines and text characteristics to students; the school, especially the principal, supervises and activates school literacy, and (5) both students, teachers and school principals provide advice to deal with these mistakes, namely the use of fun learning media and creating a comfortable learning atmosphere, habituation to using PUEBI, as well as synergy from related parties.
PEMBELAJARAN MENULIS ARGUMENTASI (STUDI KASUS PADA SISWA SMA MUHAMMADIYAH 1 KARANGANYAR KELAS X ICT)
Authors: Nugroho Sidiq , Setiawan Budhi , Purwadi Purwadi
Published: January 2022

The aims of this research was: (1) describe the planning of learning to write argumentation, (2) describe the implementation of learning to write argumentation, (3) describe the learning appraisal of argumentation, (4) describe the problems faced in learning to write argumentation, (5) In overcoming the problems encountered in learning to write arguments. This research is a kind of qualitative research with case study approach. The conclusions of this study are as follows. First, the planning of learning to write argumentation consists of syllabus and learning implementation plan. Second, the implementation of learning to write argumentation is quite optimal. Third, the assessment is conducted in two ways: direct and indirect assessment. Fourth, the problems experienced when the implementation of learning took place include: the limited allocation of learning time, the low interest of students, students difficult to pour ideas and ideas into the form of writing, low student vocabulary, and limited facilities and infrastructure. Fourth, the teacher's effort to overcome the problems in the implementation of learning to write argumentation that teachers maximize the delivery of materials, teachers seek a new atmosphere, teachers ask students to create a framework of writing, teachers ask students to make a reading summary, and teachers carry out learning in the language or library laboratory.
PEMBELAJARAN BAHASA INDONESIA SECARA ONLINE PADA MASA PANDEMI COVID-19 DI SMA ISLAM TERPADU NUR HIDAYAH SUKOHARJO
Authors: Nusantari Septirini Sekar , Sumarwati Sumarwati , Anindyarini Atikah
Published: January 2022

This study aims to determine the obstacles to learning Indonesian online and efforts to solve them at SMAIT Nur Hidayah Sukoharjo. This type of research is descriptive qualitative. The data collection technique was carried out by document analysis, observation and interviews. Data analysis used in this research is data collection, data reduction, data presentation and conclusion. The results showed that the obstacles experienced by teachers and students during online learning were supervision, learning applications, learning facilities and internet networks.
PENGARUH MODEL VAK (VISUAL, AUDITORI, KINESTETIK) BERBASIS FILM ANIMASI TERHADAP KEMAMPUAN MEMERANKAN CERITA FABEL SISWA SMP
Authors: Nudianti Anise , Sumiyadi Sumiyadi , Nugroho Rudi Adi
Published: January 2022

Penelitian ini berpijak adanya permasalahan dalam pembelajaran fabel khususnya seni peran. Penelitian ini mengujicobakan model pembelajaran VAK (Visual, Auditorial, Kinestetik) yang melibatkan tiga unsur gaya dalam pembelajarannya, yaitu penglihatan, pendengaran, dan gerakan. Penerapan model VAK ini dibantu dengan menggunakan media film animasi. Adapun tujuan penelitian ini adalah untuk menguji ada tidaknya perbedaan kemampuan bermain peran cerita fabel antara kelas eksperimen yang menggunakan model VAK melalui film animasi dengan kelas kontrol yang menggunakan model konvensional. Sampel penelitian ini adalah 32 peserta didik kelas VII C sebagai kelas eksperimen dan 32 peserta didik kelas VII D sebagai kelas kontrol di SMP Negeri 12 Bandung. Penelitian ini menggunakan pendekatan eksperimen kuasi dengan desain nonequivalent control group. Rata-rata pretest kelas eksperimen adalah 48, sedangkan kelas kontrol 47. Rata-rata posttestkelas eksperimen adalah 85, sedangkan kelas kontrol 55. Hasil uji hipotesis menunjukkan bahwa Ho ditolak dan Ha diterima. Artinya, terdapat perbedaan signifikan kemampuan memerankan tokoh fabel antara sebelum dan sesudah diterapkannya model VAK melalui film animasi. Dengan demikian, model VAK melalui film animasi efektif diterapkan dalam pembelajaran memerankan fabel.
In silico and in vitro analysis of recombinant arginine deiminase from Pseudomonas furukawaii as a potential anticancer enzyme
Authors: Dhankhar Rakhi , Kawatra Anubhuti , Gupta Vatika , Mohanty Aparajita , Gulati Pooja
Published: January 2022

Arginine deiminase (ADI), a promising anticancer enzyme from Mycoplasma hominis, is currently in phase III of clinical trials for the treatment of arginine auxotrophic tumors. However, it has been associated with several drawbacks in terms of low stability at human physiological conditions, high immunogenicity, hypersensitivity and systemic toxicity. In our previous work, Pseudomonas furukawaii was identified as a potent producer of ADI with optimum activity under physiological conditions. In the present study, phylogenetic analysis of microbial ADIs indicated P. furukawaii ADI (PfADI) to be closely related to experimentally characterized ADIs of Pseudomonas sp. with proven anticancer activity. Immunoinformatics analysis was performed indicating lower immunogenicity of PfADI than MhADI (M. hominis ADI) both in terms of number of linear and conformational B cell epitopes and T cell epitope density. Overall antigenicity and allergenicity of PfADI was also lower as compared to MhADI, suggesting the applicability of PfADI as an alternative anticancer biotherapeutic. Hence, in vitro experiments were performed in which the ADI coding arcA gene of P. furukawaii was cloned and expressed in E. coli BL21. Recombinant ADI of P. furukawaii was purified, characterized and its anticancer activity was assessed. The enzyme was stable at human physiological conditions (pH 7 and 37 ⁰C) with Km of 1.90 mM. PfADI was found to effectively inhibit the HepG2 cells with an IC50 value of 0.1950 IU/ml. Therefore, the current in silico and in vitro studies establish PfADI as a potential anticancer drug candidate with improved efficacy and low immunogenicity.
EDChannel: Channel Prediction of Backscatter Communication Network Based on Encoder-Decoder
Authors: Li Dengao , Wen Yongxin , Xu Shuang , Wang Qiang , Bai Ruiqin , Zhao Jumin
Published: January 2022

Backscatter communication networks have attracted much attention due to their small size and low power waste, but their spectrum resources are very limited and are often affected by link bursts. Channel prediction is a method to effectively utilize the spectrum resources and improve communication quality. Most channel prediction methods have failed to consider both spatial and frequency diversity. Meanwhile, there are still deficiencies in the existing channel detection methods in terms of overhead and hardware dependency. For the above reasons, we design a sequence-to-sequence channel prediction scheme. Our scheme is designed with three modules. The channel prediction module uses an encoder-decoder based deep learning model (EDChannel) to predict the sequence of channel indicator measurements. The channel detection module decides whether to perform a channel detection by a trigger that reflects the prediction effect. The channel selection module performs channel selection based on the channel coefficients of the prediction results. We use a commercial reader to collect data in a real environment, and build an EDChannel model based on the deep learning module of Tensorflow and Keras. As a result, we have implemented the channel prediction module and completed the overall channel selection process. The experimental results show that the EDChannel algorithm has higher prediction accuracy than ARIMA, linear regression (Linear), and autoregression (AR). The overall throughput of our scheme is improved by approximately 2.9% and 17.4% over random frequency hopping in both stable and unstable environments.
Treatment of industrial effluent by synthesized Nano-composite ZrCdPbO4 through solar energy
Authors: lohar saroj , Kumawat Adhidesh S. , Chouhan Jeevan Kunwar , Prajapati Dushyant Kumar , Bhardwaj Shipra
Published: January 2022

Water is the most essential natural resource for living beings, animals and plants but unfortunately it is being polluted by various means. Coloured pollutants, mainly dyes contribute maximum to this. Thus an attempt is made to remove such pollutants in an eco friendly manner. Novel nano sized composite material ZrCdPbO4 is synthesized by coprecipitation method, characterized by UV-vis, IR, FESEM, XRD, XPS and EDX analysis methods and is used for removing such pollutants from water. The emphasis of the present work is to use the prepared material as photocatalyst for degradation of various pollutants. Experimental details of degradation of a common industrial effluent, Azure-A dye as role model are discussed. Number of factors are varied to obtain maximum degradation rate through pseudo first order kinetic study. Hydroxyl radicals are found to play important role in cleavage of various bonds of the pollutant and is endorsed by scavenger study. LCMS/MS analysis is carried to rule out the route of the degradation. Final products are ascertained by laboratory tests.
LncRNA HCP5 Promotes ADSC Adipogenic Differentiation via Its Sponging of miR-27a-3p and a Concomitant Increase in PPARγ Expression
Authors: Shi Yao , Chen Hao
Published: January 2022

Current studies have shown that lncRNA plays an essential regulatory role in the physiological metabolism of cells. lncRNA HCP5 promotes proliferation and invasion in tumor cells and regulates differentiation in some stem cells. Our study was designed to determine the effects of HCP5 on the adipogenic differentiation of adipose-derived stem cell (ADSCs) and explore its underlying molecular mechanisms. ADSCs are known for their pluripotent differentiation potential and ready availability, making them promising intermediates for cell-based tissue damage repair. Our data revealed that HCP5 expression was elevated in differentiation-induced ADSCs, and that its overexpression promoted adipogenic differentiation in these cells. Then we predicted and then confirmed the effects of targeted interaction between HCP5 and miR-27a-3p. We also predicted and confirmed that miR-27a-3p demonstrated some binding affinity for PPARγ and then used this information to design a gain-and-loss-of-function experiment to verify that HCP5 regulates ADSCs adipogenic differentiation via its regulation of miR-27a-3p and PPARγ. These experiments showed that HCP5 overexpression promotes adipogenic differentiation in ADSCs, which was impaired by the upregulation of miR-27a-3p. Overexpression of miR-27a-3p inhibited PPARγ expression, and overexpression of HCP5 restored this inhibitory effect. Finally, transfection with PPARγ siRNAs reduced the adipogenic promotion due to HCP5 overexpression in these cells. Taken together our data suggest that the HCP5/miR-27a-3p/PPARγ axis may be a major regulator of adipogenic differentiation in ADSCs, which might be the probable molecular mechanism underlying the effects of HCP5 in these cells.
Application of Risk Scoring System in Intra-operative Cell Salvage Patients: A Retrospective Study Based on Multicenter Data
Authors: Lyu Bin , Liu Xinghui , Chen Daijuan , Chen Meng , Gou Jinhai
Published: January 2022

Background: Intraoperative cell salvage (IOCS) is widely used in cesarean section, and this study applied use of multi-center big data of IOCS in cesarean section to establish a bleeding risk assessment scale for IOCS patients. The purpose of this retrospective study was to explore the safety, health economy, and application guidelines of IOCS in obstetrics.Methods: We included 2621 patients who received IOCS technology during cesarean section in 12 hospitals between January 2012 - January 2020. The patients were divided into two groups, Group A, intraoperative blood loss <1500 ml; Group B, intraoperative blood loss ≥1500 ml. The clinical and imaging data associated with the risk of bleeding in patients taking IOCS were collected, and multivariable logistic regression analysis was conducted to develop a scoring system.Results: All patients who received IOCS in our study had no serious adverse outcomes. Multivariate logistic regression analysis was performed by selecting significant indicators from the univariate analysis and high-risk factors related to bleeding. The variables were maternal age ≥35 years, number of cesarean sections, placental attachment position, and placenta previa, each scored 1 point; placenta accreta, blood pool in the placenta, abnormal retroplacental myometrium, placenta protruding to the anterior uterine wall and continuous disruption of the myometrium, each scored 2 points; and cervical canal invasion, scored 4 points. All were risk factors for intraoperative blood loss volume ≥1500 ml in IOCS patients. A bleeding risk scoring system was constructed according to the above indicators. The area under the curve of the receiver operating characteristic curve (AUC) of the scoring system was 0.837, and a total score of 5 points was identified as the optimal cut-off value, allowing good differentiation of intraoperative massive bleeding in IOCS patients (AUC, 0.837; 95% confidence interval, 0.820–0.854), along with a sensitivity of 81.2% and specificity of 75.3%.Conclusion: IOCS technology is a safe and effective hemostatic measure in obstetric cesarean section. Moreover, the bleeding risk scoring system could better guide the clinical application of IOCS technology. Therefore, strictly mastering the clinical application guidelines of IOCS can save medical resources and reduce the economic burden on patients.
Solar Radio Emission as A Disturbance of Radiomobile Networks
Authors: Muratore Giuliano , Giannini Teresa , Micheli Davide
Published: January 2022

This paper analyses the effects of solar radio emissions in the radiomobile context, for the first time leveraging massive ETSI (European Telecommunications Standards Institute) 3GPP (3rd Generation Partnership Program) MDT (Minimization of Drive Test) radio measures produced by 4G LTE (Long Term Evolution) terminals and by 4G LTE BS (Base Station) cells. A method to study solar noise effects starting from radiomobile 3GPP standard MDT measures is illustrated and correlated with the excellent 10.7 cm (2800 MHz) indicator of solar activity (National Research Council Canada). The effects of solar disturbance on the LTE radio access network (RAN) for mobile services are analysed, and possible countermeasures are presented from the perspective of radiomobile network evolution to 5G and 6G.
DNA Barcoding Provides Insights Into Fish Diversity and Molecular Taxonomy of the Amundsen Sea
Authors: Cao Shuai , Li Yuan , Miao Xing , Zhang Ran , Lin Longshan , Li Hai
Published: January 2022

The Southern Ocean is experiencing complex climate change, and the Amundsen Sea is one of the regions that responds most rapidly to climate change. Due to their role in ecosystems, environmental sensitivity and high endemism, Antarctic demersal fish are a favourable group that can act as an indicator to indicate the response of Antarctic organisms to climate change. However, our knowledge of Antarctic fish fauna is insufficient, with knowledge gaps even in their taxonomy. This situation is greatly influenced by the limitations of traditional taxonomy and thus calls for alternative solutions such as DNA barcoding. In this study, DNA barcoding analyses of 69 fish samples obtained from the Amundsen Sea were conducted using the mitochondrial COI gene. Based on molecular species delimitation results, 13 fish species belonged to two orders, six families, and 12 genera. Both the maximum likelihood and Bayesian inference methods showed that the phylogenetic relationships of Bathydraconidae were paraphyletic, which was consistent with previous phylogenetic research. Our research showed that the COI gene, as a DNA barcode, not only is suitable for the identification of Antarctic fish species but also reflects some phylogenetic characteristics that might provide important evidence and support for studies of Antarctic fish phylogenetic relationships. In summary, our study provides an important reference for fish diversity and taxonomy in the Amundsen Sea, which may further enhance our understanding of the biodiversity, taxonomy and biogeography of fish in this area.
Development of an in-house Quantitative ELISA for the Evaluation of Different Covid-19 Vaccines in Human
Authors: GDOURA MARIEM , Ghaloum Fatma Ben , HAMIDA MERIEM BEN , CHAMSA WAFA , TRIKI HENDA , Bahloul Chokri
Published: January 2022

Purpose: Reliable serological assays are needed to understand the real impact of COVID-19. In order to compare the efficiency of different COVID-19 vaccines used in the National Vaccination Program in Tunisia, we have developed a quantitative in-house ELISA. Methods: The ELISA is based on the ectodomain of the SARS-CoV-2 Spike Baculovirus recombinant protein. We have used a panel of 145 COVID-19 RT-PCR positive serum samples and 116 pre-pandemic serum samples as a negative panel. The validation was carried out by comparison to four commercial techniques (Vidas® SARS-CoV-2 IgG anti-RBD Biomérieux®, Elecsys® Anti-Nucleocapsid of SARS-CoV-2 Roche®, cPass® GenScript® and the quantitative Elecsys® Anti-RBD of SARS-CoV-2, Roche®). For the evaluation of the National Vaccination campaign, we have included 115 recipients of one of the different used vaccines.Results: The qualitative performances of the developed ELISA gave 96% sensitivity, 97.5% specificity and 0.968 accuracy. For the evaluation of the different brand of vaccines in recipients not previously infected with SARS-CoV-2, it seems that mRNA vaccine of Pfizer/BioNTech has shown a higher efficacy compared to inactivated virus vaccines. COVID-19 convalescent individuals have generated poor antibody responses. Nevertheless, when they are vaccinated with any brand of the COVID-19 vaccines, many of them mounted an exponential increase of the induced immune responses, qualified as a “hybrid vigor immunity”.Conclusion: Our developed in-house ELISA seems to be very efficient in evaluating the effectiveness of anti-COVID-19 vaccination. Platforms based on mRNA vaccine are better performing than that based on inactivated virus.
On The Prediction of Landslide Occurrences and Sizesvia Hierarchical Neural Networks
Authors: Aguilera Quinton , Lombardo Luigi , Tanyas Hakan , Lipani Aldo
Published: January 2022

For more than three decades, the scientific community that studies landslides through data-driven models has focused on estimating where landslides occur across a given landscape. This concept is widely known as landslide susceptibility. And, it has seen a vast improvement from old bivariate statistical techniques to modern deep learning routines. Despite all these advancements, no spatially-explicit data-driven model is currently capable of also predicting how large landslides may be once they trigger in a specific study area. In this work, we exploit a model architecture that has already found a number of applications in landslide susceptibility. Specifically, we opt for the use of Neural Network (NN). But, instead of focusing exclusively on where landslides may occur, we extend this paradigm to also spatially predict classes of landslide sizes. As a result, we keep the traditional binary classification paradigm but we make use of it to complement the susceptibility estimates with a crucial information for landslide hazard assessment. We will refer to this model as Hierarchical Neural Network (HNN) throughout the manuscript. To test this analytical protocol, we use the Nepalese area where the Gorkha earthquake induced tens of thousands of landslides in 2014. The results we obtain are quite promising. The component of our HNN that estimates the susceptibility outperforms a binomial Generalized Linear Model (GLM) baseline we used as benchmark. We did this for a GLM represents the most common classifier in the landslide literature. Most importantly, our HNN also suitably performed across the entire procedure. As a result, the landslide-area-class prediction returned not just a single susceptibility map, as per tradition. But, it also produced several informative maps on the expected landslide size classes. Our vision is for administrations to consult these suite of model outputs and maps to better assess the risk to local communities and infrastructure. And, to promote the diffusion of our HNN, we are sharing the data and codes in the supplementary material in the hope that we would stimulate others to replicate similar analyses.
Shock Wave Induced Switchable Phase Transition (Molecular Distortion Type) of Ammonium Sulfate Crystal
Authors: Sivakumar A , Eniya P. , Dhas S.Sahaya Jude , Sivaprakash P. , Kumar Raju Suresh , I.Almansour Abdulrahman , Sundar J.Kalyana , Chakraborty Shubhadip , Arumugam S. , Dhas Martin Britto
Published: January 2022

In the present context, ammonium sulfate (NH4)2SO4 crystal phase stability has been examined at shocked conditions and observed that the title crystal undergoes the reversible crystallographic phase transitions with respect to the number of shock pulses and the observed phase transition sequence is Pnam-Pnam-distorted Pnam- Pnam-Pnam for 0,1,2,3, and 4 shocks, respectively and the observed phase transition sequence is evaluated by X-ray diffraction (XRD), Raman spectroscopy and optical spectroscopy (UV-DRS). Based on the observed analytical experimental results, it is authenticated the occurrence of the reversible phase transition which is caused by the molecular distortions accompanied by the rotational disorder of ammonium and sulfate groups of ions because of the impact of shock waves. This report is the first of its kind regarding the switchable phase transition inclusive of static temperature experiments observed for title crystal.
Motivations, Sources of Influence and Barriers To Being a Podiatrist: A National Questionnaire of Student Views
Authors: Wallis Lucy , Faulkner James , Locke Rachel , Harden Beverley , Cowley Emma E
Published: January 2022

Background

Podiatry is an allied health profession which has seen a substantial decline in numbers in recent years. Every effort is required to recruit more students to reverse this diminishing supply and meet national foot health needs. To increase the number of applications to podiatry courses and encourage individuals to choose podiatry careers, it is important to understand the key motivations, sources of influence and barriers to choosing a podiatry career among current podiatry students, and consider the influence of choosing podiatry before or after a first career.
Methods

An online questionnaire, comprising mainly Likert-scale questions, was disseminated to podiatry students in England between February and March 2021. Respondents to the questionnaire were categorised as individuals who had either decided to engage in the profession ‘before’ or ‘after’ a first career. Mann-Whitney U non-parametric difference tests were performed to compare outcome questions relating to motivations, sources of influence and barriers between groups.
Results

115 students completed the questionnaire. Overall, the study demonstrated many similarities between the groups (before and after a first career). However, there were distinct differences when considering some of the motivations (i.e., intellectually stimulating, student bursaries), sources of influence (i.e., own patient experience) and barriers (i.e., financial, job availability) associated with engaging in the podiatry profession. Overall, altruistic reasons were the key motivations for choosing podiatry. Personal sources of influence such as conducting own research, was the most important source of influence. Similar to other studies, a lack of awareness of the podiatry profession and what it entails remains problematic.
Conclusions

This is the first national questionnaire investigating career choice decision-making for podiatry students in England or in any other country. The similarities suggest that marketing is applicable to both groups. However, an absolute must is a future national strategy that makes educational sources more impactful. Additionally, following the Covid-19 pandemic, the increased interest in health and care professions suggests now is the right time to market podiatry to individuals looking for a career change. Finally, the influence of personal encounters with podiatrists shows the transformational role podiatrists can have in recruiting to the profession.
Influence of SiO2 form the rice husk ash and coal fly ash particles on the mechanical behaviour and grain characteristics of the stir-casted hybrid composites
Authors: Olorunyolemi Oladipupo Charles , Ogunsanya Olusegun Adebayo , Akinwande Abayomi Adewale , Balogun Oluwatosin Abiodun , Kumar M. Saravana
Published: January 2022

The grain characteristics and mechanical properties of aluminium composites reinforced with Rice Husk Ash (RHA) and Coal Fly Ash (CFA), produced by double stir casting in a sand mould, were investigated. As-cast Al.6063 alloys contained eutectic silicon with sharp, long elongated laths which reduces strength and limits their applications. Cold rolling operation was selected to break those eutectic laths and refine the grains for the purpose of property enhancement. RHA and CFA were chosen because they are economical, possess low density and are available in enormous quantities as solid waste by-products. They contain a substantial concentration of SiO2 and serve as a viable reinforcement for improving mechanical properties of aluminium composites. The reinforcements were added in varying concentrations (1.5 and 3.0 wt.%). Six specimens were fabricated of which five were cold-rolled. Image J and Origin software was used in evaluating the average grain size of the fabricated alloys and its composites. The results were discussed with the help of grain size distribution and profile plots. Structural and composition analysis were done using scanning electron microscopy (SEM), EDX and XRD. Hardness and tensile tests were conducted on the aluminium composites. The results indicated that Al.6063-3 wt.% CFA composite demonstrated the best balance of mechanical properties with hardness of 79 HV, tensile strength of 151 MPa and average grain size of 11.39 µm. This improvement is linked to the effect of SiO2 in CFA and plastic deformation of the specimens.
All Position-independent and Position-dependent Geometric Error Measurement and Identification of Precision Horizontal Boring Machine Tool
Authors: Guo Shijie , Tang Shufeng , Wu Jianxin , Qiao Guan
Published: January 2022

Geometric error is the main obstacle that affects the quasi-static accuracy of horizontal boring machine tool. To improve quasi-static performance, the error terms that all PIGEs and PDGEs must be measurement and identified precisely. This study proposes a novel methodology for measuring and identifying that the above two types of geometric errors based on DBB for rotary axis. The error terms of linear axis are identified from measurement model based on exponential product method and a preset measure trajectory, and the measure coordinate system be unified together with reference coordinate to lower the uncertainty of identification accuracy, and then Elastic Net method and improved weight function IGG3-LTS method are established to identify the PIGEs and PDGEs of rotary and linear axes respectively. This method has the advantage that measurement with built in-sensors method that synchronously without interfering with the running state of the machine tool, and neither the inaccuracy of reference-frame misalignment nor installation error of the measuring instrument affects the geometric error identification results of linear axis. , the other is all PIGEs and PDGEs particular to rotary axis of horizontal boring machine tool are determinated accurately. The measurement and identify strategy is demonstrated by experimental comparison on a four-axis precision horizontal boring machine tool, the minimum compensation rate of each precision index of test specimen is 40.0%, the average compensation rate is 52.7%, and the maximum compensation rate is 62.5%. under the actual condition of machine tool.
Health Workers' Use of Routine Health Information and Related Factors at Public Health Institutions in Illubabor Zone, Western Ethiopia
Authors: Benti Amanuel , Hajito Kifle Woldemichael , Daka Dawit Wolde , Ergiba Meskerem Seboka , Senay Asaye Birhanu , Abdi Ketema Lemma , Wordofa Muluemebet Abera
Published: January 2022

Background: Proper utilization of health data has paramount importance for health service management. However, it is less practiced in developing countries, including Ethiopia. Therefore, this study aimed to assess routine health information utilization and identify factors associated with it among health workers in the Illubabor zone, Western Ethiopia.Methods: A facility based cross-sectional study was conducted from March to June 2021 with a total of 423 randomly selected health workers. Data were collected using an interviewer-administered questionnaire that was developed based on the performance of routine information system management (PRISM) framework. We created composite variables for health workers' knowledge, attitude, abilities, and information utilization based on existing data. Multivariate logistic regression analysis was performed and the statistical association between the outcome and independent variables was declared using 95 percent CI and a P-value<0.05Results: About two-thirds or 279 health workers (66.0 percent, 95 percent CI: 61.3, 70.4) had good health information utilization. Two-thirds of health workers think organizational decision-making culture (67.1 percent, 95 percent CI: 62.6, 71.5) and facility managers' or supervisors' promotion of information use (65.5 percent, 95 percent CI: 60.9, 69.9) are positive. Over half of health workers (57.0 percent, 95 percent confidence interval: 52.2, 61.6) have a positive attitude toward data management, and the majority (85.8 percent, 95 percent confidence interval: 82.2, 88.9) believe they are competent of performing routine data analysis and interpretation activities. Only about two-thirds of health workers (65.5 percent, 95 percent CI: 60.9, 69.9) were proficient in data analysis and interpretation.Conclusions: The use of routine health information was higher than the national target and data from other literatures, yet an unacceptably large number of health personnel did not use information. As a result, efforts should be made to increase health workers' data management knowledge and skills, as well as the organizational culture of data utilization.
Exercise Training After Isoproterenol in Middle-Aged Female Rats Reversed Effects on the Heart, Without Affecting the Brain
Authors: Tóth Kata , Oroszi Tamás , Zee Eddy A. , Nyakas Csaba , Schoemaker Regien G.
Published: January 2022

Introduction Females with cardiovascular disease may be more susceptible to concomitant mental problems, such as depression and cognitive decline. Exercise training has beneficial effects on the cardiovascular system as well as on mental functions. Aim of the present study was to study the effects of exercise training on heart, brain and behavior in the isoproterenol (ISO) model in middle-aged female rats. Methods Twelve months old female Wistar rats were submitted to ISO injections (70 mg/kg s.c., on two consecutive days) or received saline. One week later, rats were assigned to either exercise training (treadmill running) or control handling for five weeks. During the last 7 days, tests were performed regarding depressive-like behavior and cognitive function. Then, rats were sacrificed and heart and brains were dissected for (immuno)histochemistry.Results ISO-induced cardiac effects were eminent from cardiac fibrosis and declined cardiac function. Exercise training reversed cardiac damage and partly restored ISO-induced cardiac dysfunction. However, ISO treatment could not be associated with neuroinflammation, nor impaired hippocampal neurogenesis or neuronal function. Accordingly, no mental problems, such as cognitive decline or depressive-like behavior were observed. Actually, hippocampal microglia hyper-ramification and increased sucrose preference were observed after ISO. Exercise left neuroinflammation and behavior merely unaltered, and even reduced neuronal function. Conclusion Our data indicated that the substantial cardiac damage after ISO in middle aged female rats, and the subsequent beneficial effects of five weeks exercise training on the heart, were not reflected in changes in the brain nor in altered behavior.
RPA2 Impairs the Endometrial Decidualization in Repeated Implantation Failure Patients
Authors: Zhao Huishan , Yu Mingwei , Cong Jianxiang , Chen Gang , Chu Yongli , Bao Hongchu , Liu Xuemei
Published: January 2022

The authors have requested that this preprint be removed from Research Square.
Prognostic value of cervical nodal necrosis on staging imaging of nasopharyngeal carcinoma in era of intensity-modulated radiotherapy: A systematic review and meta-analysis
Authors: Ai Qi-Yong H. , Hung Kuo Feng , So Tiffany Y. , Mo Frankie K.F. , Chin Wing Tsung Anthony , Hui Edwin P. , Ma Brigette B.Y. , King Ann D.
Published: January 2022

Purposes

To systematically review and perform meta-analysis to evaluate the prognostic value of cervical nodal necrosis (CNN) on the staging computed tomography/magnetic resonance imaging (MRI) of nasopharyngeal carcinoma (NPC) in era of intensity-modulated radiotherapy.
Methods

Literature search through PubMed, EMBASE, and Cochrane Library was conducted. The hazard ratios (HRs) with 95% confidence intervals (CIs) of CNN for distant metastasis-free survival (DMFS), disease free survival (DFS) and overall survival (OS) were extracted from the eligible studies and meta-analysis was performed to evaluate the pooled HRs with 95%CI.
Results

Nine studies, which investigated the prognostic values of 6 CNN patterns on MRI were included. Six/9 studies were eligible for meta-analysis, which investigated the CNN presence/absence in any nodal group among 4359 patients. The pooled unadjusted HRs showed that the CNN presence predicted poor DMFS (HR =1.89, 95%CI =1.72-2.08), DFS (HR =1.57, 95%CI =1.08-2.26), and OS (HR =1.87, 95%CI =1.69-2.06). The pooled adjusted HRs also showed the consistent results for DMFS (HR =1.34, 95%CI =1.17-1.54), DFS (HR =1.30, 95%CI =1.08-1.56), and OS (HR =1.61, 95%CI =1.27-2.04). Results shown in the other studies analysing different CNN patterns indicated the high grade of CNN predicted poor outcome, but meta-analysis was unable to perform because the heterogeneity of the analysed CNN patterns.
Conclusion

The CNN observed on the staging MRI is a negative factor for NPC outcome, suggesting that the inclusion of CNN is important in the future survival analysis. However, whether and how should CNN be included in the staging system warrant further evaluation.
Occurrence, distribution and health risk assessment of potentially toxic elements in soil: A case study from semi-arid region of southwest Punjab, India.
Authors: . Karanveer , Bala Ritu , Das Debabrata
Published: January 2022

Numerous groundwater studies exist on the heavy metal (HM) pollution in Punjab, however, research is quite limited in the soil system of the region. In the current work, detailed study has been carried out on the distribution of toxic metals in the agricultural and barren soil (AS & BS) samples in the semi-arid region of Punjab. Pollution level of HMs was determined by using various pollution indices like geo-accumulation index (Igeo), enrichment factor (EF), pollution index and pollution load index (PLI), and potential ecological risk assessment (PERI). A total of 11 toxic elements were measured and 2 fold values were observed in the AS samples. Range of HMs in the AS samples were 3.9 – 28.1, 29.2 - 90, 6.7 – 32.8, 4.2 – 65.6, 13019.5 – 43900, 95.7 – 553, 13.1 – 42.1, 16.5 – 25.2, 82 – 267, 25 – 78.6, 25.4 – 131.8 mg/kg for As, Cr, Cu, Co, Fe, Mn, Ni, Pb, Sr, V and Zn respectively. It is seen that there is high variability in the spatial distribution of metals throughout the region indicating the role of anthropogenic activities. Pollution levels reveal the studied region to be moderately contaminated in terms of anthropogenic pollution. Multivariate statistical analysis results also revealed that the majority of HM pollution in the region is due to anthropogenic activities with few elements to be of geogenic origin. Potential health risks assessment is carried out and total hazard index (HI) values were in the acceptable range but the total cancer risks were comparatively higher for children than adults. This study shows the risk of heavy metal contamination in the agricultural regions and the results obtained have global implications.
Umbilical cord mesenchymal stem cells-derived exosomes deliver miR-21 to promote corneal epithelial wound healing through PTEN/PI3K/Akt pathway
Authors: Liu Xiaolong , Li Xuran , Wu Guangyuan , Qi Pengfei , Zhang Yanyan , Liu Zhiyu , Li Xinyue , Yu Yu , Ye Xiangmei , Li Yang , Yang Dongguang , Teng Yueqiu , Shi Ce , Jin Xin , Qi Sen , Liu Yuting , Wang Shudan , Liu Ying , Cao Fenglin , Kong Qingran , Wang Zhenkun , Zhang Hong
Published: January 2022

Objective: Rapid restoration of corneal epithelium integrity after injury is particularly important for preserving corneal transparency and vision. Mesenchymal stem cells (MSCs) can be taken into account as the promising regenerative therapeutics for improvement of wound healing processes based on the variety of the effective components. The extracellular vesicles form MSCs, especially exosomes, has been considered as important paracrine mediators though transferring microRNAs into recipient cell. This study investigated the mechanism of human umbilical cord MSC-derived exosomes (HUMSC-exosomes) on corneal epithelial wound healing.Methods: Exosomes extracted from HUMSCs were identified by transmission electron microscopy, nanoparticle tracking analysis, and Western blot. Corneal fluorescein staining and histological staining were evaluated in a corneal mechanical wound model. Changes in HCECs proliferation after HUMSC-exosomes or miR-21 mimics treatment were evaluated by CCK-8 and EdU assays, while migration was assessed by in vitro scratch wound assay. Full-length transcriptome sequencing was performed to identify the differentially expressed genes associated with HUMSC-exosomes treatment, followed by validation via real-time PCR and Western blot.Results: The exosomes derived from HUMSCs can significantly promote corneal epithelial cells proliferation, migration in vitro and corneal epithelial wound healing in vivo. Similar effects were obtained after miR-21 transfection, while the beneficial effects of HUMSC-exosomes were partially negated by miR-21 knockdown. Results also show that the benefits are associated with decreased PTEN level and activated the PI3K/Akt signaling pathway in HCECs.Conclusion: HUMSC-exosomes could enhance the recovery of corneal epithelial wounds though restraining PTEN by transferring miR-21, and may represent a promising novel therapeutic agent for corneal wound repair.
Transcriptomic Analysis Reveals the Mechanism of Host Growth Promotion by Endophytic Fungus of Rumex Gmelinii Turcz.
Authors: Ding Changhong , Wang Shouyu , Li Jiabin , Wang Zhenyue
Published: January 2022

Rumex gmelinii Turcz. (RGT) is a medicinal plant of Rumex in Polygonaceae. Our research group isolated an endophytic fungus plectosaphaerella cucumerina (Strain J-G) from RGT, which could promote the growth of the host significantly when was co-cultured with the host. In this study, we mainly used transcriptomic analysis to explore the molecular mechanism of the growth promoting effect. It was found that during the process of co-culture with Strain J-G, metabolism of amino acids, the synthesis and metabolism of carbohydrates in RGT tissue culture seedlings were all promoted, which provided sufficient material and energy basis for the growth of plants. In addition, response to hormones such as auxin and cytokinin in RGT tissue culture seedlings was improved significantly, which promoted the growth and development of plants. The repairing ability of DNA in RGT tissue culture seedlings was also enhanced to provide a good guarantee for the growth of plants. Meanwhile, defense system of RGT tissue culture seedlings was also mobilized by the existence of Strain J-G, therefore more secondary metabolites and stress resistant substances were produced to ensure the normal growth and metabolism of plants.
A comparative Study of Tonification and Sedation in Moxibustion using Computer Method
Authors: Liu Miao , Kauh S.K. , Lim Sabina
Published: January 2022

Moxibustion is an important and widely used treatment method in traditional medical science. Two methods of moxibustion exist: tonification and sedation. Although these two methods have been used for thousands of years, there still has been no scientific comparative study of their effects on the skin until now. Thus, this paper aims to use a mathematical method to study moxibustion methods in skin tissue to demonstrate a difference of thermomechanics between tonification and sedation. In this paper, the temperature, burn damage, and thermal stress distributions in the skin tissue is analyzed and the results showed that the thermomechanical behavior of skin tissue between tonification and sedation is in accordance to ancient literatures of traditional medicine. Therefore, the comparative study of heat transfer and related thermomechanics in skin tissue during these treatments thermomechanics to tonification and sedation is great importance and helpful in exploring moxibustion instruments and their standardization contribute to the further developments of these medical applications.