bluuebunny/crossref_metadata_2025 huggingface dataset:
Etiо pathogenesis of spontaneous abortion
Authors: Arganova О. N. , Kosheleva N. G.
Published: November 2021

One studied immunologic and genetic aspects of spontaneous abortion and the placenta insufficiency role in this pathology. It was determined, that increasing the production of cytokines by placenta's macrophages through something leads to increasing the reduced myometrium activity. Under cariotyping husbands and wives had spontaneous abortions on early terms it was found various genic and endocrine disturbtions. Modern topic diagnostics and algorithm of pregnancy observation with consideration of spontaneous abortion etiopathogenesis, treatment and placenta insufficiency prophylactics have permitted in most cases (more 93%) to give normal term of birth, to decrease perinatal losses.
Disturbtion of the endosalpingeal ultra-structure as a sterility cause under distal uterine tube occlusion
Authors: Lyatoshinskaia Р. V. , Kira Evgenii F. , Bezhenar Vitalyi F. , Novozhylova А. Р.
Published: November 2021

We analyzed the ultra-structure of endosalpingian microbiopsies in 26 infertile patients with hydrosalpingites. We calculated the percentage of ciliated cells and estimated different parameters including the height of the epithelium, the presence of adhesions, epithelial desquamation, inflammatory cells and fibrosis in the wall. The microbiopsies were also investigated for their fine structure by transmission microscopy. Abnormalities of the kinocilia were detected. It was found that the formation of the hydrosalpingites is followed by the development of the deep dystrophic changes in endosalpinx. The latter can be the reason for the functional tubal disability in infertile patients.
Tromboembolic complications in obstetric- gynecological practices
Authors: Bezhenar V. F. , Tsveliov Yu. V. , Kaplun I. В. , Levshankov А. I. , Shchiogolev А. V. , Kandyba D. V. , Savello А. V.
Published: November 2021

In clinical lecture, etiology, pathogenesis, principles of diagnostics and methods for treatment of tromboembolic complications, which the most often an obstetric- gynecologist meets in its practice. Authors present their own clinical observations, which allow to them formulating the main principles of tromboembolism prophylaxis in obstetrics and gynecology.
Diagnostics and treatment of dysfunctional uterine bleeding in the perimenopause
Authors: Tarasova М. A. , Yarmolinskaya М. I.
Published: November 2021

The reasons of dysfunctional menometrorrhagia in the perimenopause are revealed in the article , the algorithm of patient examination and necessity of differential diagnostics are given, methods of hormonal and surgical treatment of this disease are presented.
Certain historical, practical and scientific aspects of prenatal diagnostics in st. Petersburg
Authors: Baranov V. S.
Published: November 2021

Prenatal diagnosis (PD), as a relatively new area of ​​medical genetics, is experiencing a period of rapid growth. Methodological problems of PD associated with the selection of women at high risk of congenital and hereditary pathology, complex examination of the fetus using non-invasive (ultrasound) and invasive (cytogenetic, molecular, biochemical) research methods have already been resolved. Further increase in the effectiveness of PD, its scientific and practical significance depends entirely on the level of organization of this service in the field and its funding. An important role in the development of modern PD in Russia was played by the PD laboratory of the N.I. BEFORE. Otta RAMS.
Reproduction immunology: old dogmas and new conceptions
Authors: Pavlov О. V. , Selkov S. A.
Published: November 2021

The article reviews the recent data concerning the role, which components of immune system play in the regulation of gestation. The evidences are provided for the participation of cytokines and immune cells in pathogenesis of pre-eclampsia and spontaneous abortion. The attempt has been made to demonstrate the evolution of ideas and conceptions in this field for past 10-15 years.
Osteoprotegerin and its ligands for regulating the osteal resorption: experimental and clinical application aspects under estrogen deficiency conditions
Authors: Yureneva S. V.
Published: November 2021

Modem conceptions concerning the role of OPG-RANK-RANKL system in a local paracrinic mechanism of the regulation of osteoclastogenesis and osteal resorption processes are presented in this article. Here, results of the first clinical researches of prognostic signification of ORG determinations for estimating disruption manifestations in osteal metabolism under estrogen deficiency conditions as well as data on the OPG use as an anti-resorbable agent at the treatment of post-menopausal osteoporosis.
Medical ethics, deontology and legislation at the obstetrician-gynecologist work
Authors: Aylamazian Е. К. , Tsveliov Y. V.
Published: November 2021

Authors put series of concrete questions concerning medical ethics and deontology at the obstetrician-gynecologist work and propose to discuss them.
"On the decent institution of Babichiev's case in favor of society" (to the 250th anniversary of the decree of the ruling Senate)
Authors: Цвелев Y. V. , Abashin V. G. , Kalchenko А. Р.
Published: November 2021

April 29 (May 5) 1754 is a significant date in Russian obstetrics. On this day, the Governing Senate approved the representation of the Medical Chancellery (the highest body of state administration of medicine in Russia at that time) by issuing the Decree of Her Imperial Majesty Elizabeth Petrovna, which laid the foundation for the organization of obstetrics in Russia. The draft Decree was prepared by the President of the Medical Chancellery Pavel Zakharovich Kondoidi.
The peculiarities of pregnancy and labor & delivery course in patients after laparoscopic correction of sterility
Authors: Chub V. V. , Shupik А. I. , Klimov V. А. , Anistratenko S. I. , Schola L. I.
Published: November 2021

Reproductive health of the woman is the important condition of favorable prospects of each nation. The overcoming of married couple sterility is a question of state importance, but correct management of pregnancy and the choice of delivery method in pregnant after operative treatment of sterility is no less significant.
The efficacy of laparoscopy in adolescent girls with purulent pelvic inflammatory disease (pid)
Authors: Karaeva K. U. , Kochreidze N. A. , Kutusheva G. F.
Published: November 2021

Material and methods. The target of medical examination of 98 adolescent girls at the age from 14 to 17 years with purulent PID was to establish the correlation between the clinical sings and the degree of destruction, revealing during
Surgical treatment of patients with proximal uterine tubes occlusion
Authors: Liatoshinskaja P. V. , Bezhenar V. F. , Tzhemchizhina T. I. , Kira Е. F.
Published: November 2021

Introduction. Uterine tubes occlusion at the proximal part is one of the causes of the tubal-peritoneal sterility at women. Frequency of proximal tubal occlusion according to various authors averages about 20%.
The expediency of mandatory combined endoscopy in increasing of assited reproductive technology efficiency
Authors: Markova Е. А. , Kuznetsova Т. A. , Vostricov V. V. , Salfetkina S. V.
Published: November 2021

Introduction. Evaluation of 168 patients participating in IVF programs was performed depending on the results of combined endoscopic examination and subsequent treatment. The pathology of endometrium was detected in more than half of the cases, while hydrosalpinx was revealed in 20% of the patients, and every tenth patient suffered from endometriosis. The expediency of the approach under the study for preparing the patients for IVF programs has been confirmed. The present study was aimed an evaluation of expediency and efficacy of combined endoscopic examination in preparing for subsequent participation of female patients in IVF programs.
Transvaginal endoscopy: new possibilities in operative gynaecology
Authors: Ogourtsov A. V. , Kabeshov А. М. , Bryantsev А. D. , Vedeneeva N. V. , Smirnova О. А. , Arkanova Е. I. , Kornyichuk J. V.
Published: November 2021

Authors have applied the method of transvaginal hydrolaparoscopy (THL) in 108 patients with previous history of tubal surgery and 4 patients with benign ovarian masses and severe postoperative adhesions of peritoneal cavity. THL allows to evaluate the effect of reconstructive reproductive surgery and determine the tactics of the further treatment of women infertility. Visual control and biopsy of inner surface of ovarian cyst is the informative tool of differential diagnosis of ovarian masses.
Adhesion prevention in reproductive surgery
Authors: Popov A. A. , Manannikova T. N. , Kirushkina О. G. , Chausova N. А. , Gluchov Е. Yu.
Published: November 2021

Introduction. Adhesion formation in abdominal cavity is one of the leading disease. Adhesion formation after pelvic surgery is the cause of ileus, sterility and chronic pelvic pain. There is no foolproof method to prevent the adhesion constitution. There are some recommendations in the literature to prevent this process: to use crystalloids and colloids after basic operative stage, dosing irrigation the cavity with isotonic solution sodium chloride with heparin, administration of the glucocorticoid.
Dynamic laparascopy as a stage of hospital rehabilitation in patients with tubal pregnancy
Authors: Shipitsyna Е. V. , Novikov А. V. , Shalepo К. V. , Bezhenar V. F. , Savicheva А. М.
Published: November 2021

Objectives: Chlamydia trachomatis infection of the upper genital tract often results in pelvic inflammatory disease (PID), and its sequels include ectopic pregnancy (EP), miscarriage and tubal infertility. This study was aimed to evaluate the rate of C. trachomatis detection as well as anti-C trachomatis antibodies in women with EP.
Endovideosurgery of benign tumors and tumor-like ovarian mass
Authors: Dyachuk A. V. , Bezhenar V. F. , Shuliko L. А. , Chmaro М. G. , Tscipurdeeva А. А.
Published: November 2021

Background: the questions of operative approach in huge and multi-stage ovarian mass, prevention of reccurence and limited factors for endoscopic surgery remained actual.
Total laparoscopic hysterectomy in the grossly enlarged uterus
Authors: Botchorishvili R. , Rabischong B. , Jardon К. , Pouly J. L. , Mage G. , Wattiez А. , Canis М.
Published: November 2021

Introduction: Avoiding laparotomy by performing laparoscopic hysterectomy, of various types, has been shown to be beneficial in a number of ways. Shorter recovery times, shorter length of hospital stay and convalescence period, and earlier return to work than after abdominal hysterectomy are some of the positive factors cited. However, it is often considered that there is a size limitation of 14-16 weeks gestation to the feasibility of laparoscopic hysterectomy. Whilst a number of studies have shown that the laparoscopic-assisted vaginal hysterectomy (LAVH) successfully manages the large uterus, little has been published regarding a total laparoscopic approach.
The total laparoscopic hysterectomy - a modern route of hysterectomy. Is there a benefit?
Authors: Holthaus В. , Kletsel A. , Mosel А. , Regidor R. A.
Published: November 2021

Objective: Total laparoscopic hysterectomy - a suitable approach to hysterectomy compared to the abdominal way.

Introduction.Hysterectomy is the most frequent surgery performed on female patients (approximately 70,000 per year in Germany). In more than 90% of the cases, it is indicated for benign disorders. In 1996 about 8% of the operation were done by laparoscopy, in 2002 it was done in about 12% of the cases. Only a very few recent publications focuses on per- and postoperative complications of the total laparoscopic hysterectomy. The advantage of the laparoscopic approach has been mainly associated with a short hospital stay and a quick convalescence. The object of this study was to list the advantage and the complications of the laparoscopic hysterectomy.
The evaluation of organ-saved surgery of benign tumors of uterus and adnexa
Authors: Zarubenko I. Р. , Ermolinskiy I. I. , Меlˊkо А. I. , Kira Е. F.
Published: November 2021

Objective: the grounding and optimization of organ-saved surgery in treatment of uterine fibroid and benign ovarian cystadenomas.
Management of urologic trauma after gynecologic and obstetric procedures
Authors: Tsivian А.
Published: November 2021

Introduction. The anatomical proximity of the lower urinary tract to the female reproductive organs renders it vulnerable to injury during obstetric and gynecologic procedures.
An estimation of organs preserved surgical treatment of benign uterine and ovarian tumors
Authors: Zarubenko I. Р. , Ermolinskiy I. I. , Kira Е. F.
Published: November 2021

The purpose of research: an estimation and optimization of organs preserved surgery of benign tumors of uterus and ovary at present time.
Evaluation of free radical processes in metabolism in combined hyperplasias of the female reproductive system
Authors: Chepur S. V. , Popov Е. N. , Niauri D. А.
Published: November 2021

Relevance. It is known that free radical metabolic reactions are involved in the development and progression of the development of various destructive and hyperplastic processes in tissues. In this regard, the aim of this study was to compare the severity of disorders of the pro- and antioxidant system in single and multiple benign tumors of the female reproductive system.
Advantages of laparoscopic- assisted vaginal hysterectomy over abdominal hysterectomy in patients with fibroids
Authors: Plekhanov A. N.
Published: November 2021

Subject matter. Subject matter was the comparative study of laparoscopic-assisted vaginal hysterectomy (LAVH) and abdominal hysterectomy (AH) in patients with 12-22 weeks pregnancy fibroid.
Surgical treatment of tubal- peritoneal sterility in patients with hydrosalpinx
Authors: Kira E. F. , Lyatoshinskaya P. V. , Bezhenar V. F.
Published: November 2021

Objective: the detrmination of indications and contraindications for reconstructive-plastic surgery of uterine tubes in patient with hydrosalpinx.

Materials and methods. We have operated 159 female patients with tubo-pertironeal sterility, which resulted from existence of hydrosalpinx. All patients were underwent salpingoneostomy with application of laparoscopic (n=122) or microsurgical (n=47) technique. In 26 cases the microbiopsy of ampullar part endosalpinx of uterine tube with subsequent investigation of its ultrastructure by method of light and electronic microscopy (microscope Hitachi, Japan) was performed.
Vaginal hysterectomy electrosurgery or sutures?
Authors: Slobodianiouk A. I. , Mazohin I. V. , Slobodianiouk В. А. , Kim Е. М. , Suchalko М. О. , Timerbekova А. Т.
Published: November 2021

Objective: to compare procedure time, blood loss, postoperative period of vaginal hysterectomy using sutures versus using an electrosurgical bipolar plasma kinetic generator GYRUS.
Our experience of laparoscopic, vaginal and laparoscopic assistance vaginal hysterectomy
Authors: Tsivyan B. L.
Published: November 2021

Introduction. Hysterectomy is the most common surgery performed by the gynecologist. There are many indications for hysterectomy and uterus can be removed using any of a variety techni ques and approaches including abdominal, laparoscopic, vaginal and laparoscopic assistance vaginal.
Our experience of treating of combined forms of endometriosis using endoscopic methods
Authors: Beriev I. V. , Tsvelev Y. V.
Published: November 2021

Introduction. Despite of effective methods of diagnosis and treatment of endometriosis, implemented in recent years, substantiation of surgical tactics and operations performing in cases of combination of genital endometriosis with involvement of the adjacent organs and cellular space still causes many difficulties.
Efficiency of different biopsy methods of adenomyosis diagnosis, comparative analisis
Authors: Povzun S. A. , Bezhenar V. F. , Tsvelev Y. V. , Fridman D. B.
Published: November 2021

Introduction.Usage of low invasive methods in adenomyosis diagnosis helps to diagnose adenomyosis definitely by histological examination of myometrium samples.
The correlation of histological and ultrasonic signs of adenomyosis
Authors: Povzun S. A. , Fridman D. B.
Published: November 2021

Introduction. Ultrasonography (USI) is a routine investigation technique in gynecology. USI - is the only method, which allows to suspect adenomyosis without invasive study.
Optimal protocol of normo- and hyperthermal intraperitoneal chemotherapy (ict) in complex management of the widespread endometriosis (iii-iv stages)
Authors: Ruhliada N. N. , Belyaev А. М.
Published: November 2021

In the hyperthermic variant, intraperitoneal chemotherapy (IVT) should be started immediately after the surgical stage. Perfusion is best accomplished by inserting 2 laparoscopic irrigation tips through the trocar ports connected to the perfusion system.
Anamnesis and menstrual function at adenomyosis patients
Authors: Fridman D. B.
Published: November 2021

Introductions. Anamnesis and clinical examination helps to determine the signs with high prognostic value for adenomyosis diagnosis, which justify usage of invasive diagnostic technique.
The role of cytotoxic cells and interferon system in regulation of processes of proliferation in endometriosis
Authors: Yarmolinskaya М. I. , Selkov S. A.
Published: November 2021

Introduction: Various components of immune system take part in pathogenesis of endometriosis. Their role might be paramount or minor during different periods of the disease.
Diagnostics and treatment of benign ovarian tumors in patients with impaired reproductive function
Authors: Kulavsky V. A. , Zharinova S. M. , Kulavsky Е. V.
Published: November 2021

The urgency of the problem. The problem of diagnosis and treatment of ovarian tumors is complex and relevant, especially when determining the possibility of carrying out organ-preserving surgery in young patients with impaired reproductive function.
Laparoscopy in the treatment of the ovarian benign tumours
Authors: Ukybasova Т. М. , Kotlobovsky V. I. , Satenova Z. K.
Published: November 2021

Introduction. The aim of the work is to study the opportunities of using endoscopy surgical methods for diagnosing and treating of different ovarian tumours.
New possibilities for eliminating prolapse and prolapse of the anterior vaginal wall and cystocele
Authors: Bahaev V. V. , Gyunter V. E.
Published: November 2021

Introduction. For many years the problem of the lowering and fallouts of vagina and womb remains to be actual. The wide-spread way of the surgical treatment of the lowering and fallouts of the front wall of vagina and cystocele is an anterior colporrhaphia. Its using is limited by difficulties of the operative technics in case of thinness and atrophies of fascia vesicovaginalis, and the high frequency of prolaps relapse.
New possibilities for reconstruction of the rectovaginal septum
Authors: Bahaev V. V. , Gyunter V. E.
Published: November 2021

Introduction. One of the serious problems of the surgical treatment of the lowering and falling of femal reproductive organs, is a reconstruction of rectovaginal septum at presence of rectocele.
The evaluation of contributing factors and outcomes of surgical treatment in patients with stress urine incontinence
Authors: Bezhenar Vitaly F. , Volkov N. N. , Blagodarnij G. V.
Published: November 2021

Introduction. Stress urine incontinence (SUI), gets the important medical and social meaning in view of its extremely high prevalence among the women of senior reproductive age, occurrence and increasing of complex of the factors promoting development of moral- psychological and social - industrial disadaptation of the women.
An application of allogenic skin's cells for a treatment of genital fistulas
Authors: Ermolinskiy I. I. , Меl՚ко А. I. , Zarubenko I. P. , Kira Е. F.
Published: November 2021

An urogenital fistulas are serious complication after heavy multiple traumas, wounds, and radical operations. We offer a method of conservative treatment of the given pathology with the help of cultures of allogenic cells.
Criteria for choosing surgical tactics for the treatment of mixed urinary incontinence in women
Authors: Gorelov A. I. , Niauri D. A. , Bezhenar V. F. , Ziyatdinova G. M. , Ivanov А. V.
Published: November 2021

The prevalence of mixed urinary incontinence among the known clinical forms of urinary incontinence in women varies from 12 to 30% (Hampel C. et al., 1997). With an unreasonable choice of surgical tactics for the treatment of mixed urinary incontinence, the effectiveness of surgery may decrease, as a rule, due to an increase in urgent symptoms (Karram M. M. et al., 1989).
Combined surgical treatment of cysto- and rectocele in descent and abasement of female reproductive organs
Authors: Korkan A. I. , Korabelnikov А. I. , Korkan I. Р.
Published: November 2021

The purpose of study: improvement of surgical treatment results of cysto- and rectocele in pelvic prolapse due to combined correction of anatomic and functional disorders using lesser invasive technologies.
Technical aspects of laparoscopic lymphodissection
Authors: Puchkov K. V. , Khubezov D. A. , Yudin I. V.
Published: November 2021

Aim. The studying of laparoscopic lymphodissection results in cancer of different location.

Material and methods. In Ryazan Regional Clinical Hospital 86 laparoscopic operations have been performed during the period 1999/2005. 64 (74,4%) patients have had colorectal cancer, 10 (11,6%) patients have had renal carcinoma and 2 (2,3%) patients - cervical carcinoma. 20 (23,2%) operations have been combined ones.

Lymphodissection technique has been identical. But lymphodissection extent was different, depending upon the spread of cancer. At colorectal cancer aortoiliac and aortoiliopelvic lymphodenectomy has been performed, depending upon tumor location. Radical nephrectomy has been accompanied by monolateral wide removal of retroperitoneal fat in aortal and iliac zones (affected side). Extend of lymphodissection has corresponded to standard radical hysterectomy in 2 patients (Vertheims operation).
Surgical repair of vaginal vault prolapse: comparing of vaginal and abdominal procedures
Authors: Korshunov М. Y. , Sazykina Е. I.
Published: November 2021

Objective. To compare the results of abdominal sacrocolpopexy and vaginal high uterosacral vaginal vault suspension with fascial reconstruction for the uterovaginal and vault prolapse repair.
Comparing outcomes of tvt versus tvt obturator sling procedures in stress urinary incontinent patients: a prospective cohort study
Authors: Korshunov М. Y. , Sergeeva L. V. , Sazykina Е. I.
Published: November 2021

Objectives. Compare the subjective and objective outcomes and quality of life (QoL) in patients who underwent either a tension-free vaginal tape (TVT) or TVT Obturator sling procedure for their stress urinary incontinence.
The experience of genital prolapse treatment and urine incontinence using synthetic materials
Authors: Krasnopolskiy V. I. , Buyanova S. N. , Petrova V. D. , Muravyeva Т. G. , Evsyukova L. V. , Putilovskiy М. А.
Published: November 2021

Background: genital prolaps which developes especially in young unipara women after noncomplicated delivery without hormonal disorders and factors provided intraabdominal pressure increasing is a common manifestation of generalized connective tissue defect (CTD) on the level of reproductive system.
Sacrovaginopexy with prolene net application in genitalia prolapsus cure
Authors: Abulhairova О. S. , Luzina L. V.
Published: November 2021

Material and methods. 170 been operated patients at age of 35-78 (average age was 47) were under dynamic observation with complex examination during 5 years. All the examined patients were divided into 5 groups according to their pathologies. The first group consisted of 24 patients with vagina prolapsus and cysto- and rectocele.
The experience of surgical treatment of stressful urinary incontinence of an average and heavy degree
Authors: Novikov Е. I. , Soroka I. V. , Ivanova L. А. , Popov А. S.
Published: November 2021

Problem: what is the effect of sling operations for patients with urinary incontonence.
Biomechanics and biocompatibility of synthetic suburethral slings
Authors: Petrov S. В. , Kurenkov А. V. , Jukovsky V. А. , Shkarupa D. D.
Published: November 2021

Aim of study: The aim of our work was to find the correlation between biomechanical properties of synthetic suburethral slings and tissue reaction after implantation of them.
Different types of tension free vaginal tapes (TVT, TVT-ovt) in treatment of stress incontinence
Authors: Popov A. A. , Shaginyan G. G. , Machanskite О. V. , Ramazanov М. R. , Kirushkina О. G.
Published: November 2021

Purpose of the study: to compare the effectiveness of surgical treatment of LMWN in women using two variants of loop urethropexy - retropubic (TVT) and transobturator (TVT-obt) approaches.
Tot and TVT-O operations, comparison and long-term results
Authors: Pushkar D. Y. , Dyakov V. Y. , Godunov B. N. , Gumin L. M.
Published: November 2021

Implantation of prolen tapes for the correction of stress incontinence is the most perspective surgical method today. Our research includes the observation over patients operated according the TOT and TVT-0 method in 2002-2005 for the purpose of evaluation of operative methods and long term results of surgical treatment.
Тhе using of transvaginal ultrasound of urethrovesical segment in different types of stress incontinence diagnostics
Authors: Prokhorova V. S. , Bezhenar V. F. , Pavlova N. G.
Published: November 2021

At present the different types of stress incontinence diagnostics and treatment are the main topics of urogynecology. T1aditional methods of clinical, urodynamic and endoscopic exams have been completed Ьу noninvasive 2D and 3D ultrasound.
Experience of surgical treatment of paraurethral cysts
Authors: Pushkar D. Y. , Dyakov D. Y. , Godunov B. N. , Gumin L. M.
Published: November 2021

Introduction and objectives. Paraurethral cysts which can be refered to nonmalignant cystic lesions of vagina are often found in urogynecologic practice. At the same time such rare pathology as diverticulum of urethra with the same symptoms can be diagnosed. The main symptoms of cysts are inflammation, pain, dyspareunia and obstructive voiding. It often requires surgical treatment. The world experience confirms that extirpation of paraurethral cysts is much more preferable than marsupialization because is more radical.
Our experience of treatment of female patients with combined uretero-vesico-vaginal fistulas
Authors: Pushkar D. Y. , Dyakov V. V. , Godunov В. N. , Gumin L. М.
Published: November 2021

Aims Objectives: combined uretero-vesico-vaginal fistulas is rare pathology with difficult diagnosis and treatment. We summarize the experience of treatment of such category of patients.
Surgical treatment of stress urinary incontinence in women
Authors: Rykin Р. A. , Komyakov В. К. , Singaevskiy S. B.
Published: November 2021

Objective. Comparison of the surgical treatment results in patients with SUI with the use of loop operations with prolen nets.
Vaginal hysterectomy of different radicality in the treatment of uterine deseases
Authors: Gabitov N. А. , Gybaidullin А. R. , Mavlutova Z. V.
Published: November 2021

Objective. The aim of this study was the optimization of vaginal hysterectomy (VH) using laparoscopic technology (LAVH) in order to improve the results in the treatment of benign and malignant deseases of uterine.
The first experience of using of argon plasma coagulation in the treatment of benign diseases of uterus cervix
Authors: Gluhov Е. Y , Kuzina Т. V. , Gromova L. М.
Published: November 2021

Urgency of research. Argon plasma coagulation (APC) as a method of monopolar high-frequency action upon a tissue, for last years is more and more widely used in endoscopy, open and laparoscopy surgery to stop bleedings and for devitalisation of superficial pathological processes. But the usage of this method in outpatient gynecology is poorly distributed.
The influence of the hysteroscopy over the nearer and the farther results of the endometrium cancer affected treatment
Authors: Gabitov N. A. , Vafina G. V. , Gubaidullin A. R. , Shaikhutdinova A. S. , Garipova G. H.
Published: November 2021

The hysteroscopy diagnostic is considered as the method of definitive diagnostic of the endometrium cancer before the operation. The hysteroscopy is worth while in cases of difficulties with the diagnostic of the diseases. It is reasonable to introduce the hysteroscopy diagnostic in the algorithm of examination of the endometrium cancer diseases.
Miniinvasive surgical intervention in diagnostic and treatment of the patients with ovarian malignant tumour of stage iv
Authors: Меl՚ко A. I. , Kira Е. F. , Ushakov I. I. , Ermolinskiy I. I. , Zarubenko I. P.
Published: November 2021

The purpose of research - to estimate an opportunity and expediency of application diagnostic laparoscopy at the patients with stage IV of ovarian malignant tumor.
Planned simultaneous laparoscopic operations in gynecology and surgery
Authors: Gordeeva Т. V. , Grigorova А. N. , Dudka Z. V.
Published: November 2021

Actuality. Increase of traumatic effect during performance of simultaneous phases and additional accesses use are presented as a major reason of surgeons rejection to perform simultaneous correction of combined diseases with laparoscopic methods. This major reason may become disputable as laparoscopic methods are introduced in contemporary medicine.
The experience of simultaneous laparoscopic operations in gynecology
Authors: Maistrenko N. A. , Beriev I. V. , Basos S. F. , Basos А. S.
Published: November 2021

Introduction. The invention of laparoscopic methods has allowed performing simultaneous operations on abdominal and pelvic organs without substantial increase in trauma caused by operational access. According to data from WHO (1985) - 20 - 30% of patients require simultaneous operations, however, only around 6% of them undergo such interventions.
The opportunities for simultaneous gynecological laparoscopic operations
Authors: Bezhenar V. F. , Rutenburg G. M. , Strizheletsky V. V. , Zhemchuzhina Т. Y. , Gordeeva Т. V.
Published: November 2021

Urgency of the problem. Extensive introduction of laparoscopy in surgery and operative gynecology, perfection of technique and low traumatic effect of endoscopic operations allow to expand indications for simultaneous laparoscopic interventions involving various abdominal organs.
Laparoscopic simultaneous operations in women
Authors: Singaevsky N. B. , Borisov А. V. , Bokuchava N. V. , Jaroslavsky V. K.
Published: November 2021

Introduction. During the last years the method of simultaneous surgery, i.e. simultaneous operations using laparoscopic approach, has been elected in increasing frequency for combined surgical internal diseases.
The experience of combined treatment of uterine submucous myoma
Authors: Zaitseva Е. G. , Marenin А. G. , Biteev V. К.
Published: November 2021

Introductions. With the advent of new technologies in medicine, with ultrasound procedures being widely spread and available to every woman the diagnosed cases of uterine pathology today are about 40%. Submucous uterine myoma is diagnosed in every 3d-4th cases of diagnosed uterine myoma.
Rehabilitation of the reproductive function in patients after intrauterine surgery of hysteromyoma
Authors: Popov E. N. , Niauri D. A. , Volkov N. N. , Djemlikhanova L. H.
Published: November 2021

Introduction. Modem surgical techniques of hysteroresectoscopy allow to perform organ-preserving operations in patients with submucous hysteromyoma. The submucous node up to 4 cm can be fully excised with electrosurgical fragmentation, if it belongs to the 0 or Ist type of localization according to European Hysteroscopists Association classification.
The comparative assessment ofcentral hemodynamics indexes changes in hysteroresectoscopy and endometrial thermoablation
Authors: Popov A. A. , Mazurskaya N. М. , Manannikova T. N. , Chausova N. А. , Zemskov Y. V.
Published: November 2021

Introduction. Traditional treatment tactics in patients with endometrial hyperplasia provides the hormonal therapy during 3 months with following histological investigation of total mucoid scrape. Surgical operation is used if there are no clinical or/and morphological effects.
Diagnostic abilities of hysteroscopy in patients with chronic endometritis
Authors: Shurshalina A. V. , Korneeva I. E. , Feoktistov А. А.
Published: November 2021

Hysteroscopy is an important diagnostic method in the gynecology practice. The visualization of the uterus cavity can detect a lot of abnormal changes, value the prevalence of the pathology process and eliminate of the abnormal tissues.
Analisis of complications of laparoscopic-assisted vaginal hysterectomy and abdominal hysterectomy
Authors: Plekhanov A. N.
Published: November 2021

Subject matter. Subject matter was the comparative study of complications of laparoscopic-assisted vaginal hysterectomy (LAVH) and abdominal hysterectomy (AH).
Prevention of complications of laparoscopic operations in gynecologic patients with adhesions
Authors: Rutenburg G. M. , Strizheletsky V. V. , Zhemchuzhina T. Y. , Gordeeva T. V.
Published: November 2021

Urgency of the problem. Last years the problem of laparoscopic operations in patients with abdominal adhesions attracted experts attention.
The first experience of gynecological laparoendoscopy
Authors: Alieva H. G.
Published: November 2021

In last 7 years 8174 surgeries were performed, 1188 from them were simultanted. Endoscopic operations became the gold standard of reconstructive surgery of infertility. 102 hysterectomies were performed from 2000 year and 210 fibroid enucleations. Ovarian tumors were the indications for surgery in 1134 cases, endometriosis - in 104 cases, extrauterine pregnancy - in 385 cases. 35 patients underwent organ-saved surgery. Laparoscopic operations allowed to decrease intraoperative trauma, blood loss, hospital stay. We had no lethal outcomes in this group of surgery.
The role of cytomegaloviral infection in young females with ovarian resistance
Authors: Protsenko A. S. , Avramenko N. V. , Strelko O. V. , Khodak G. P. , Protsenko V. N.
Published: November 2021

Introduction. The study is aimed at the evaluation of the effects of cytomegaloviruses (CMV) on the development of ovarian resistance (OR) and at the development of a package of diagnostic and therapeutic measures in patients with such pathology.
Markers of connective tissue dysplasia in patients with chronic venouse insufficiency
Authors: Rusina E. I.
Published: November 2021

Introduction. Pelvic varicose is associated with different gynecologic diseases (myoma, ovarian tumors, endometriosis and others). Also it may be the independent disorder and cause chronic pelvic pain, sterility. The role of connective tissue disoders in varicose progressing is studed actively.
Establishment of urgent gynecological endovideosurgery in conditions of small town
Authors: Sheshunov I. V. , Danilov D. V. , Subbotin D. N. , Rozuvan А. А.
Published: November 2021

Material and methods. To assess the psychological reaction to the stress connected to the laparoscopic intervention Spilberg - Hanyn scale have been used. Comparative analysis was used in two groups of patients with fallopian tube rupture (as a result of tubal gestation). In the Ist group there were 15 patients who had undergone laparoscopic surgery. In the IInd group there were 15 patients who had undergone laparotomy. In both groups average age of patients was 28 3,1 and 30 2,3 respectively. We estimated correlation between degree of anxiety and risk appraisal for surgical treatment of patients with ectopic pregnancy in both groups.
Bioactive compounds from Lactarius deterrimus interfere with the invasive potential of gastric cancer cells
Authors: Król Kamila , Pudełek Maciej , Krzysiek-Mączka Gracjana , Wierdak Mateusz , Muszyńska Bożena , Sułkowska-Ziaja Katarzyna , Krakowska Agata , Ryszawy Damian , Czyż Jarosław
Published: November 2021

Stomach cancer is the 4th most common cancer diagnosed worldwide. Despite intensive research on its etiopathology, its treatment strategies have not changed in the last 50 years. Mushrooms have recently attracted much attention as the source of bioactive compounds that can potentially complement cancer therapies. Here, we extracted a phenolic fraction from Lactarius deterrimus and analyzed its composition and bioactivity against the gastric cancer (AGS) cells. The complexity of L. deterrimus compounds was revealed by an HPLC assay, and was accompanied by cytostatic, cytotoxic and anti-invasive effects of the L. deterrimus extract (LDE). These are illustrated by inhibition of the AGS cells’ proliferation, metabolic activity and motility, and by induction of the cytoskeleton rearrangements. Apparently, these effects are exerted via activation of intracellular oxidative stress and decreased ATP production in AGS cells that could not be compensated by induction of autophagy. Less severe LDE effects were seen on physiology of normal gastric fibroblasts; however, inhibition of their motility indicates that LDE can interfere with gastric cancer development via an effect on stromal cells. Along with the observed synergy of LDE and cisplatin/5-fluorouracil effects on AGS cells, our data show the potential of LDE for supplementation of the gastric cancer therapy.
Towards understanding the novel adhesin function of Candida albicans phosphoglycerate mutase at the pathogen cell surface: some structural analysis of the interactions with human host extracellular matrix proteins
Authors: Satala Dorota , Zelazna Aleksandra , Satala Grzegorz , Bukowski Michal , Zawrotniak Marcin , Rapala-Kozik Maria , Kozik Andrzej
Published: November 2021

Although many atypical proteinaceous cell wall components that belong to a group of multitasking, "moonlighting" proteins, have been repeatedly identified in numerous pathogenic microorganisms, their novel extracellular functions and secretion mechanisms remain largely unrecognized. In Candida albicans, one of the most common fungal pathogens in humans, phosphoglycerate mutase (Gpm1) - a cytoplasmic enzyme involved in the glycolysis pathway - has been shown to occur on the cell surface and has been identified as a potentially important virulence factor. In this study, we demonstrated tight binding of C. albicans Gpm1 to the candidal cell surface, thus suggesting that the readsorption of soluble Gpm1 from the external environment could be a likely mechanism leading to the presence of this moonlighting protein on the pathogen surface. Several putative Gpm1-binding receptors on the yeast surface were identified. The affinities of Gpm1 to human vitronectin (VTR) and fibronectin (FN) were characterized with surface plasmon resonance measurements, and the dissociation constants of the complexes formed were determined to be in the order of 10–8 M. The internal Gpm1 sequence motifs, directly interacting with VTR (aa 116-158) and FN (aa 138-175) were mapped using chemical crosslinking and mass spectrometry. Synthetic peptides with matching sequences significantly inhibited formation of the Gpm1-VTR and Gpm1-FN complexes. A molecular model of the Gpm1-VTR complex was developed. These results provide the first structural insights into the adhesin function of candidal surface-exposed Gpm1.
Dental Prostheses and Risk of Medication-related Osteonecrosis of the Jaw
Authors: De Castro Luciano Alberto , Watanabe Satiro , De Castro Luciano Leite
Published: November 2021

The article's abstract is not available.
Poisoning and its Management in Healthcare Facilities in Lagos State, Nigeria
Authors: Joda Arinola , Ajetunmobi Oluwaseun , Olugbake Olubusola
Published: November 2021

Background: Poisons are chemical substances that produce harmful effects on the body. About 0.3 million people die annually from poisoning. Poisons are produced by animals, plants, microorganisms, and food contamination. Poisoning is a global public health problem, especially in children and teenagers and healthcare providers ought to provide protocols for its management.
Objectives: The main aim of this study was to document the mode, knowledge of antidotes, and management of poisoning by healthcare providers in selected community pharmacies and hospitals in Lagos state.
Methods: This study was a descriptive cross-sectional study. The study data were collected using questionnaires administered to 112 providers in selected community pharmacies and hospitals in Lagos state. The obtained data were collated and analyzed using SPSS version 20.0. Results were presented as frequency tables and charts.
Results: A response rate of 85.7% was achieved. The most common mode of poisoning was accidental (89% and 68% among pharmacists and physicians, respectively) and the highest incidence was among children 0-5 years old (41.5% and 48.3% among pharmacists and physicians, respectively). Management was mainly via gastric decontamination with activated charcoal in pharmacies and supportive care in the hospitals. Knowledge and availability of antidotes and management of poisoning were poor.
Conclusion: Management of poisoning was generally inadequate and the prominence of a poison control center was recognized. The establishment of poison control centers in healthcare facilities and the organization of updated lectures for healthcare providers will go a long way to improving poisoning management in the state.
The Effect of Inclusive Quality Management on the Educational Accreditation Results of the Educational Centers of Mazandaran University of Medical Sciences in 2015-2018
Authors: Malekzadeh Roya , Amuei Fattane , Mahmoudi Elaheh , Abedi Ghasem , Mohammadi Hamidreza
Published: November 2021

Background: The Deming model is an effective method for comprehensive quality management.
Objectives: This study aimed to investigate the effect of inclusive quality management on the educational accreditation results of the educational hospitals in the Mazandaran Province, Iran.
Methods: This interventional study was conducted in 5 hospitals. In this study, the Deming cycle validation model was employed. This model, which is based on the checklist for the educational centers of the Ministry of Health and Medical Education, has 91 benchmarks for 81 standards. Descriptive statistical methods (Wilcoxon and Friedman nonparametric tests) were used to analyze the data.
Results: A significant difference was observed among the accreditation scores of the hospitals before and after the intervention (P<0.05). The accreditation score obtained by the educational centers improved by 41.1, 37, 15.7, 53.2, and 49.2 units. Besides, the intervention outcomes in all areas of accreditation, except facilities management, space, facilities, equipment, and resources, were significantly different.
Conclusion: The use of the Deming cycle has proved effective in performing the educational accreditation of the centers, which can be achieved with continuous and proper implementation. This study can help improve the standards of education of the educational centers.
Inhibitory Effects of Salinispora-derived Metabolites Against Multidrug Resistance: An In-silico Study
Authors: Ghandadi Morteza
Published: November 2021

Background: Multi Drug Resistance (MDR) is known to defeat most chemotherapies as one of the main anticancer strategies. The role of overexpression or overactivation of ATPBinding Cassette (ABC) transporters, especially P-glycoprotein (P-gp), in the development of chemotherapy has long been demonstrated. Salinispora is a marine actinomycete genus known for the production of novel bioactive metabolites.
Objectives: In this study, the potential of Salinispora derived metabolites as inhibitor of ATPbinding cassette (ABC) transports have been investigated using in-silico approaches.
Methods: Physicochemical, pharmacokinetic and drug likeness of the Salinispora derived metabolites have been analyzed using SwissADME server. This was accompanied by the employment of docking strategy to evaluate anti-MDR potential of the metabolites using P-gp, Breast Cancer Resistance Protein (BCRP) and Multidrug Resistance Protein 1 (MRP-1) as target proteins.
Results: Nineteen metabolites were found to have demonstrated appropriate physicochemical, pharmacokinetic, and drug-likeness properties and were involved in the docking studies. Based on docking studies, saliniquinones, cyclomarazine, and cyanosporoside A demonstrated ABC transporters inhibitory potential.
Conclusion: Our results suggest that further in vivo and in vitro studies on anti-MDR effects of Salinispora-derived metabolites are warranted.
Safety Assessment of a New Strain of Lactobacillus pentosus (IBRC=11143) As a Candidate Probiotic
Authors: Bahrehvar Saba , Khezri Shiva , Barzegari Amir Abbas , Nejati Vahid
Published: November 2021

Background: It is believed that the consumption of an adequate amount of live lactic acid bacteria (as probiotic) may improve the health of the host. Many strains of lactic acid bacteria are generally considered to be safe. However, some strains have shown some adverse effects.
Objectives: This study aimed to investigate the safety of a new strain of Lactobacillus pentosus (IBRC=11143) in Wistar rats
Methods:In this experimental study, male and female Wistar rats (n=6) were used. A subacute toxicity study (for 28 days) was conducted by oral administration of Lactobacillus pentosus to the animals. In each sex, one group received saline, and the other two groups received the bacteria at doses of 1×108 and 1×109 Colony-Forming Units (CFU)/rat.
Results: No significant alteration in the liver and kidney tissues was seen. However, in both sexes, there were significant differences in urea and creatinine levels between the control and the experimental groups. Some blood parameters (Lymphocyte, red blood cell, hematocrit, and hemoglobin) also showed significant changes in the groups that received the bacteria. Moreover, a significant increase in alkaline phosphatase level was observed in male rats.
Conclusion: The results indicate that Lactobacillus pentosus (11143) is not entirely safe like other Lactobacillus strains. Therefore, the Lactobacillus pentosus (11143) strain may not be the right choice as a probiotic for human consumption.
Assessment of Anticonvulsant Activities of Petroleum Ether Extract of Anacyclus pyrethrum Roots on Experimental Rats
Authors: Yousef Bashir A. , Awad Zeinab , Adam Somaya , Abdelgadir Setalbanat , Mergani Ansam
Published: November 2021

Background: Epilepsy is one of the most common neurological conditions and a significant cause of morbidity and mortality.
Objectives: The present study aimed to evaluate the anticonvulsant activity of the petroleum ether extract of the root of Anacyclus pyrethrum on Pentylenetetrazole (PTZ)-induced seizure model in Wistar rats.
Methods: The composition of the petroleum ether extract of A. pyrethrum was first analyzed using Gas Chromatography-Mass Spectrometry (GC-MS). Subsequently, the anticonvulsant activities of these extracts (70 and 140 mg/kg, intraperitoneal injection) were evaluated on PTZ-induced seizures in rats. The protection rate against induced seizures, latency, and duration of seizures, as well as neurological symptoms, were assessed and compared to those protected by phenobarbital.
Results: GC/MS analysis of the petroleum ether extract showed that the main components were octadecadienoic acid, hexadecanoic acid, diheptylcyclopropene, naphthalene, and methyl stearate. The extract (70 and 140 mg/kg) was found to provide significant protection against PTZ-induced seizures. Moreover, compared to the negative control, the extracts increased the latency of induced-convulsion and reduced the duration of epilepsy. Interestingly, the extracts showed a reduction in neurological symptoms and the severity of seizures compared to the negative control. All of these outcomes manifested in a dose-dependent manner.
Conclusion: The petroleum ether extract of A. pyrethrum may produce anticonvulsant effects by reducing the duration of seizures and delaying the latency of seizures induced by PTZ.