bluuebunny/crossref_metadata_2025 huggingface dataset:
Load Rating of Reinforced Concrete Slab Bridges Using Field Testing
Authors:   University of Illinois Urbana-Champaign, Andrawes Bassem , Colombani Isaias ,   University of Illinois Urbana-Champaign, Mirdad Md Abdul Hamid ,   University of Illinois Urbana-Champaign, Chen Alexander ,   University of Illinois Urbana-Champaign
Published: December 2024

Bridge load-rating analysis is typically used to assess the safe load-carrying capacity of bridges. However, in many cases, this analytical approach was proven to be too conservative, which leads to unnecessary bridge postings and road restrictions. In such cases, field testing is sought as a more reliable method for assessing the structural condition of the investigated bridge. This study focused on investigating the efficacy and practicality of performing load rating on reinforced concrete slab bridges in Illinois using two field testing methods—namely, diagnostic and proof load testing. The versatility of both methods was examined through testing six different slab bridges of varying characteristics and conditions. The tested bridges included single- and double-span bridges with span lengths varying between 20.5 ft and 32 ft, and skew angles varying between 0 and 55 degrees. The bridges also varied in age, with the first tested bridge’s construction dating as far back as 1925. The research assessed the type of instrumentation and data acquisition system used as well as the challenges associated with setting up these devices in the field. The analytical and field-based load-rating factors were compared for each bridge. The results showed the effectiveness of field testing in providing a relatively fast and reliable assessment of the structural condition of the investigated bridges. The methods adopted and developed in this research will assist the Illinois Department of Transportation in making future decisions about the condition of bridges in Illinois.
Terapia Antiplaquetária Dupla Combinada em Pacientes com Doença Arterial Coronariana em uma População na Turquia: DAPT-TR
Authors: Öz Ahmet , Toprak Kenan , Aydin Ertan , Saraç İbrahim , Doğduş Mustafa , Opan Selçuk , Yenerçağ Mustafa , Tascanov Mustafa Begenc , Kümet Ömer , Karaağaç Miraç , Özmen Murat , Murat Bektaş , Kertmen Ömer , Bekler Özkan , İnci Sinan , Huyut Mustafa Ahmet , Özderya Ahmet , Er Fahri , Duran Mustafa , Ardahanlı İsa , Baş Mehmet Memduh , Güzel Tuncay , Ceyhun Gökhan , Özdemir İbrahim Halil , Özen Mehmet Burak , Gündüz Ramazan , Erdoğan Aslan , Çetin İlyas , Barış Veysel Özgür , Yayla Çağrı , Karaduman Medeni , Aşkın Lütfü , Bekar Lütfü , Tanrıverdi Okan , Özkan Eyüp , Yeşil Emrah , Çalışkan Serhat , Kuzu Zülfiye , Uğuz Berat , Böyük Ferit , Kunak Ayşegül Ülgen , Murat Selda , Asil Serkan , Kayhan Özkan , Erdoğan Emrah , Duz Ramazan , Katkat Fahrettin , Ekin Tuba , İbişoğlu Ersin , Ateş Bilge Nazar , Ayça Burak , Ergene Asım Oktay , Zoghi Mehdi
Published: December 2024

Resumo Fundamento A Terapia Antiplaquetária Dupla (DAPT, do inglês dual antiplatelet therapy) é o tratamento de escolha para pacientes com síndromes coronarianas agudas e crônicas, uma vez que ela reduz mortalidade e previne complicações trombóticas recorrentes. A avaliação da carga isquêmica e do risco de sangramento é crucial na escolha da DAPT e de sua duração. Objetivos O objetivo de nosso estudo foi conduzir um acompanhamento clínico prospectivo de pacientes recebendo terapia combinada (AAS 75mg + clopidogrel 75 mg). Nosso estudo é um estudo multicêntrico, transversal, observacional, do tipo coorte. Métodos Foram incluídos 1500 pacientes que iniciaram DAPT combinada para o tratamento de síndrome coronariana aguda ou síndrome coronariana crônica. Os desfechos primários foram internação hospitalar por qualquer motivo, internação por causa cardiovascular, infarto agudo do miocárdio, trombose de stent, revascularização de vaso alvo e sangramento; os desfechos secundários foram morte por qualquer razão ou por causa cardiovascular e acidente vascular cerebral. O nível de significância adotado na análise estatística foi 5%. Resultados A idade mediana foi 63 anos; 78,5% dos pacientes estavam recebendo DAPT por síndrome coronariana aguda. As taxas de internação por causas cardiovasculares, de infarto agudo do miocárdio, de trombose de stent e de revascularização de vaso alvo foram 7,9%, 2,3%, 1,3% e 4,2%, respectivamente. Enquanto a taxa de sangramento segundo a escala BARC tipo 1 foi de 3,3%, a taxa de sangramento BARC tipo 5, 3, ou 2 foi 0,6%. As taxas dos desfechos secundários morte por qualquer razão, morte por causa cardiovascular e acidente vascular cerebral foram 0,5%, 0,3% e 0,3%, respectivamente. Conclusão Nosso estudo mostrou que a DAPT em regime combinado de doses fixas de AAS e clopidogrel é eficaz e seguro em pacientes com síndrome coronariana aguda ou crônica adequadamente selecionados.
Analisis Penyajian Laporan Keuangan Berdasarkan Peraturan Pemerintah Nomor 71 Tahun 2010 Pada Pengadilan Negeri Slawi Kelas I B
Authors: Fadhillah Subekti  , Harjanti Ririh , Aryanto Aryanto
Published: December 2024

Government Accounting Standards are accounting principles that are applied in prepareing  government financial reports in transparent and accountable manner. Pengadilan Negeri Slawi Kelas I B is one of the accounting entities under Mahkamah Agung republic Indonesia which is obliged to carry out accounting and accountability reports on the implementation of state revenue and expenditure budget. The purpose of this research was to determine the presentation of financial statement based on PP No. 71 of 2010 at the Pengadilan Negeri Slawi Kelas I B. Methods of collecting data  use in this research was observation, interview, and study of literature. The analysis method used is descriptive qualitative methode. The results of the research show that the components of the financial reports of the Pengadilan Negeri Slawi Kelas I B, namely Budget Realization Report, Balance Sheet, Operational Report, Changes of Equity Report, and Notes to Financial Statement has been appropriate besed on PP No. 71 of 2010. Nonethless, there are still posts in the Budget Realization Report that haas not been included.
Pengaruh Board Diversity Dan Sales Growth Terhadap Financial Distress Yang Dimoderasi Oleh Board Remuneration Pada Perusahaan Pertambangan Di Indonesia
Authors: Bangun Bastanna Erlayas , Bahtiar Usman  , Hartini
Published: December 2024

This study aims to analyze influence of the independent variables Board Diversity (consisting of Demographic Diversity and Cognitive Diversity) and Sales Growth on the dependent variable Financial Distress with the moderating variable being Board Remuneration and the control variables Firm Size, Company Age, Total Asset Turn Over in mining companies listed on the BEI (Exchange Indonesian Effect) during the period 2018 - 2022. The study sample was selected using a purposive sampling method so that 43 (forty three) companies were obtained that met the criteria to become the sample. Data analysis used to test the hypothesis is multiple regression analysis using the Eviews-12 program. In predicting the value of financial distress, the author uses the Zmijewski model analysis or what is often known as the X-Score method.
Based on the results of study that has been carried out, it is known that the Board Diversity variable, especially the Demographic Diversity variable, has a negative influence on Financial Distress, and the Sales Growth variable for both the Demographic Diversity and Cognitive Diversity variables has a positive influence on Financial Distress.
The results of this study also show that the two Board Diversity variables, namely Demographic Diversity and Cognitive Diversity and Sales Growth on Financial Distress are moderated by Board Remuneration, so the one that has an influence is Sales Growth, both for the two components, namely Demographic Diversity and Cognitive Diversity, which have a negative influence.
LITERATURE REVIEW: PENERAPAN AKUNTANSI LINGKUNGAN PADA PENGOLAHAN LIMBAH RUMAH SAKIT DI PULAU JAWA
Authors: Tiara Bunga Anggraeni
Published: December 2024

Akuntansi lingkungan merupakan salah satu cabang akuntansi social yang merupakan wujud tanggung jawab pada ilmu akuntansi yang berfungsi untuk mengidentifikasi, mengakui, mengukur, menyajikan, dan mengungkapkan akuntansi lingkungan. Tujuan dari penelitian ini adalah untuk mengetahui bagaimana penerapan akuntansi lingkungan pada pengolahan limbah rumah sakit dipulau jawa. Penelitian ini menggunakan data sekunder. Metode analisis data yang digunakan dalam penelitian ini adalah metode literature review. Literatur review adalah sebuah metode yang sistematis, eksplisit dan reprodusibel untuk melakukan identifikasi, evaluasi dan sintesis terhadap karya-karya hasil penelitian dan hasil pemikiran yang sudah dihasilkan oleh para peneliti dan bertujuan untuk membuat analisis dan sistesis terhadap pengetahuan yang sudah ada terkait topic yang akan diteliti untuk menemukan ruang kosong bagi penelitian yang akan dilakukan. Penelitian dilakukan dengan mereview artikel/jurnal penelitian, standar akuntansi, dan regulasi yang berhubungan, dengan fokus pada penerapan akuntansi lingkungan pada pengolahan limbah di rumah sakit. Hasil penelitian ini adalah Rumah Sakit Provinsi Jawa yang telah melaksanakan penerapan akuntansi lingkungan pada pengolahan limbah dengan baik. Penerapan akuntansi lingkungan pada pengelolaan limbah rumah sakit berpengaruh terhadap lingkungan sebagai bentuk pencegahan terhadap pencemaran lingkungan sekitar.
KOKO KOSWARA MUSISI YANG PROGRESIF DAN REVOLUSIONER
Authors: Dinda Sabdha Yogaswara  , Anggy Giri Prawiyogi
Published: December 2024

Koko Koswara atau dikenal dengan panggilan Mang Koko merupakan seorang kreator kosmopolit modern pada zamannya. Melalui media musik karawitan Sunda serta kreativitasnya dapat melahirkan ratusan karya yang berlabelkan wanda anyar (1950-an), hingga ia dinobatkan sebagai pembaharu karawitan Sunda pada tahun 1970-an. Artikel ini bermaksud untuk menggali faktor-faktor apa saja yang menyebabkan Koko Koswara berhasil dan diakui sebagai seniman besar dan karya-karyanya dapat bermanfaat bagi masyarakat, khususnya para seniman Sunda hingga ia pantas dikatakan sebagai musisi yang progresif dan revolusioner. Proses penelitian ini termasuk pada jenis penelitian kualitatif dengan menggunakan metode deskriptif analitis. Adapun hasil dari penelitian ini menunjukkan: (1) hal-hal yang mendukung terhadap proses Koko Koswara menjadi seniman besar dalam karawitan Sunda; (2) landasan berfikir Koko Koswara sebagai musisi karawitan Sunda; (3) beberapa musisi lainnya sebagai pemantik Koko Koswara dalam berkarya; dan (4) pengklasifikasian karya dari ratusan karya yang dihasilkannya.
PENGARUH KEPEMIMPINAN KEPALA SEKOLAH DAN KOMPETENSI GURU TERHADAP KINERJA GURU MADRASAH ALIYAH SE-KABUPATEN PURWAKARTA
Authors: Nasir  , Abdurahman Saleh  , Asep Anwar Sidik  , Asep Yuliana
Published: December 2024

Permasalahan dalam penelitian ini: (1) apakah ada pengaruh Kepemimpinan kepala sekolah terhadap kinerja guru di madrasah aliyah se-kabupaten purwakarta? (2) Apakah ada pengaruh kompetensi guru terhadap kinerja guru di madrasah aliyah se-kabupaten purwakarta ? (3) Apakah ada pengaruh Kepemimpinan kepala sekolah dan kompetensi guru terhadap Kinerja Guru di madrasah aliyah se-kabupaten purwakarta?. Tujuan penelitian ini adalah untuk mengetahui (1)untuk mengetahui apakah ada pengaruh kepemimpinan kepala sekolah terhadap kinerja guru, (2) untuk mengetahui apakah ada pengaruh kompetensi guru terhadap kinerja guru, (3) untuk mengetahui apakah ada pengaruh kepemimpinan dan kompetensi guru secara bersamaan terhadap kinerja guru.
PENGARUH DAYA INGAT DAN METAKOGNITIF DENGAN PRESTASI KENAIKAN KELAS III SISWA SEKOLAH DASAR DI PROVINSI BANTEN
Authors: Agus Suherman  , Aries Denta Putra  , Elfa Ridhaswara  , Rusman Zaenal Abidin  , Rusbiansyah Perdana Kusuman
Published: December 2024

Penelitian ini bertujuan untuk menguji hipotesis pengaruh daya ingat, dan metakognitif siswa terhadap hasil belajar siswa dengan memperhitungkan pengaruh efek moderasi Hasil Belajar. Penelitian dilakukan dengan pendekatan kuantitatif asosiatif kausal. Penelitian dilakukan di sekolah dasar (SD) di Kota Tangerang dengan sampel penelitian sebanyak 353 siswa SD sebagai responden penelitian. Teknik analisis dilakukan secara statistik deskriptif dan inferensial dengan menggunakan alat analisis data SPSS versi 3.0. Hasil penelitian membuktikan bahwa secara langsung sikap siswa, metakognitif siswa, dan Hasil Belajar memiliki pengaruh yang signifikan terhadap hasil belajar siswa. Dari penelitian ini memberikan manfaat yang besar bagi dunia pendidikan agar mendapatkan solusi dalam upaya meningkatkan prestasi hasil belajar siswa SD di Propinsi Banten.
AUDIT SISTEM INFORMASI PEMBELIAN PERALATAN PADA PT SAITAMA STAMPING INDONESIA
Authors: Avincennia Vindy Fitriana  , Svetlana Puteri Kirana
Published: December 2024

PT. Saitama Stamping Indonesia atau yang lebih dikenal dengan nama PT. SSI adalah sebuah perusahaan yang bergerak di bidang manufaktur asal jepang memproduksi spare part untuk industri otomotif dengan proses stamping dan perakitan welding. Laporan Kerja Praktik ini bertujuan untukmengetahui seluruh proses pembelian peralatan dan sistem informasi akuntansi yang ada di PT. Saitama Stamping Indonesia. Metode yang digunakan dalam penulisan ini menggunakan metode deskriptif kualitatif dimana teknik pengambilan data dilakukan pada saat observasi. Jenis dan sumber datadiperoleh dari Data primer melalui wawancara dengan koordinator keuangan. Secara keseluruhan sistem informasi pembelian ini perlu diperbaiki lagi guna meminimalisir sistem yang error karena terkendala koneksi internet, server yang overload karena tidak diperbarui atau dikembangka n, dan perlu tindakan scanning data secara rutin agar menghindari terjadinya virus masuk lewat data atau file – file yang dimasukkan ke komputer.
Dewan Redaksi
Authors: Susanto Erwin
Published: December 2024

Dewan Redaksi
INSECURE ATTACHMENT DAN REGULASI EMOSI SEBAGAI PREDIKTOR TERHADAP KECENDERUNGAN MELAKUKAN KEKERASAN DALAM BERPACARAN
Authors: Nuram Mubina  , Annisa Nadiyanti  , Lenisa Fitri
Published: December 2024

Penelitian ini memiliki tujuan untuk memprediksikan faktor yang berpengaruh terhadap kecenderungan kekerasan dalam berpacaran pada dewasa awal dilihat dari insecure attachment dan regulasi emosi. Responden dalam penelitian ini berjumlah 155 responden yang berdomisili di Kabupaten Karawang. Penelitian ini dilakukan dengan metode penelitian kuantitatif dengan jenis asosiatif kausalitas. Pengambilan data responden menggunakan tiga instrumen skala psikologi yang dimodifikasi dari The Revised Conflict Tactic Scale untuk mengukur kekerasan dalam berpacaran dan diadaptasi dari Experince in Close Relationship-Revised serta Emotion Regulation Quesionaire untuk mengukur insecure attachment dan regulasi emosi. Data penelitian diolah menggunakan SPSS 27 menggunakan uji analisis regresi berganda. Hasil dari penelitian ini menunjukkan bahwa insecure attachment dan regulasi emosi berpengaruh terhadap kecenderungan melakukan kekerasan dalam berpacaran. Besar pengaruh kedua varibel tersebut secara simultan adalah 35,7% dan 64,3% lainnya dipengaruhi oleh variabel lain yang tidak diteliti dalam penelitian ini.
This research aims to predict factors that influence the tendency to violence in dating in early adulthood in terms of insecure attachment and emotional regulation. Respondents in this study totaled 155 respondents who live in Karawang Regency. This research was carried out using quantitative research methods with associative causality type. Respondent data were collected using three psychological scale instruments modified from The Revised Conflict Tactic Scale to measure violence in dating and adapted from Experience in Close Relationships-Revised and the Emotion Regulation Questionnaire to measure insecure attachment and emotional regulation. Research data was processed using SPSS 27 using multiple regression analysis tests. The results of this study show that insecure attachment and emotional regulation influence the tendency to commit violence in dating. The magnitude of the influence of these two variables simultaneously is 35.7% and the other 64.3% is influenced by other variables not examined in this study.
PERAN ORANG TUA DALAM MENDAMPINGI ANAK DENGAN GANGGUAN KECEMASAN DI RTB PASURUAN
Authors: Talitha Nahda Amilia  , Muhammad Jamaluddin
Published: December 2024

Penelitian ini bertujuan untuk memahami peran orang tua dalam mendampingi anak dengan Gangguan Kecemasan di RTB Pasuruan, dengan fokus pada pola asuh. Gangguan kecemasan merupakan kondisi di mana seseorang mengalami kecemasan dan ketakutan yang intens dan persisten, bahkan terhadap bahaya yang sebenarnya tidak ada atau berlebihan. Hal ini dapat mengganggu kehidupan sehari-hari penderitanya. Penelitian ini menggunakan metode kualitatif untuk mempelajari lebih dalam tentang gangguan kecemasan. Teknik yang digunakan untuk mengumpulkan data adalah observasi, wawancara, dan dokumentasi. Triangulasi metode diterapkan untuk memastikan validitas dan kredibilitas data yang diperoleh. Hasil penelitian menunjukkan bahwa orang tua memiliki peran penting dalam mendampingi anak dengan gangguan kecemasan. Gangguan kecemasan pada anak dapat diatasi dengan pola asuh yang tepat dan dukungan profesional. Dalam kasus SH, gejala kecemasan yang semakin memburuk perlu ditangani oleh profesional kesehatan mental agar anak dapat pulih dan kembali menjalani hidup normal.
This study aims to understand the role of parents in assisting children with Anxienty Disorders in RTB Pasuruan, with a focus on parenting. Anxiety disorders are conditions in which a person experiences intense and persistent anxiety and fear, even of dangers that do not actually exist or are excessive. This can interfere with the daily life of the sufferer. This research uses qualitative methods to learn more about anxiety disorders. The techniques used to collect data were observation, interview, and documentation. Triangulation of methods was applied to ensure the validity and credibility of the data obtained. The results showed that parents have an important role in assisting children with anxiety disorders. Anxiety disorders in children can be overcome with proper parenting and professional support. In the case of SH, worsening anxiety symptoms need to be treated by mental health professionals so that the child can recover and return to living a normal life.
Respiratory sinus arrhythmia in humans: Correlation analysis with breathing-specific heart rate
Authors: Mortola Jacopo P.
Published: December 2024

In adult humans at rest, pulmonary ventilation and cardiac output share similar values, both approximately 5 L/min. Airflow is intermittent, with tidal volumes exceeding dead space, low breathing frequency (fresp), and zero air velocity at both end-inspiration and end-expiration. In contrast, the cardiac pump is in series with the vasculature, such that the small stroke volume and high heart rate (HR) (fh) allow for quasi-continuous blood flow. Based on experimental findings in dogs, it has been suggested that an elevated fh during inspiration (known as respiratory sinus arrhythmia [RSA]) decreases the disparity between air and blood flow patterns. Thus, one might hypothesize a positive correlation between the peak-trough difference of instantaneous fh (ΔHR’ = HR’peak – HR’trough) and the breathing-specific fh (fh/fresp). To test this hypothesis, we combined breath-by-breath data for ΔHR’ from several previous studies, resulting in a database of over 600 subjects. This extensive dataset allowed us to construct statistically meaningful correlations between ΔHR’ and variables associated with RSA (fh, fresp, HR’peak, and HR’trough). A strong statistically significant (r > 0.9) correlation between fh/fresp and ΔHR’ was observed. These findings support the hypothesis that RSA may be a mechanism for improving the match between the quasi-continuous blood flow and the intermittent airflow.
Effects of Wnt signaling pathway on tertiary lymphoid structure in the immune microenvironment of colorectal cancer with different MMR subtypes
Authors: Feng Huijing , Han Fei , Xu Huiru , Zhang Siyuan , Zhou Qiuru , Ma Yanan , Wang Lin , Yang Xuena , Wei Feng , Zhao Hua , Ren Xiubao
Published: December 2024

Tertiary lymphoid structure (TLS) and tumor-resident memory T cells (TRM), as the important components of tumor microenvironment, play key roles in the anti-tumor immunity and therapy functions in cancer patients. However, the TRM and TLS distribution in colorectal cancer (CRC) patients with different mismatch repair (MMR) subtypes and Wnt pathway activation, as well as their relationship, remain underexplored. In this study, we evaluated the MMR subtypes and Wnt/β-catenin using immunohistochemical staining and analyzed their relationship in a sample of 117 cases. We detected TLS distribution, quantity, and maturity in CRC samples of different MMR subtypes by multiple immunofluorescence staining and analyzed its correlation with Wnt/β-catenin pathway. We then detected TRM expression inside and outside the TLS and tumor tissues in 34 CRC samples by means of multiple immunofluorescence staining and analyzed its correlation with Wnt/β-catenin pathway. Our study showed that the proportion of β-catenin in MMR-proficient (pMMR) CRC was significantly higher than that in MMR-deficient (dMMR) CRC. The peritumoral and intratumoral TLS quantity in dMMR group was obviously higher than that in high and low pMMR-β-catenin expression groups. The intratumoral TLS quantity negatively correlated with β-catenin expression in dMMR group and low pMMR-β-catenin group, respectively. In addition, the positive rate and density of CD8+TRM in the TLS were significantly higher than that outside. The positive rate and density of CD8+TRM of tumor tissues in dMMR CRC were higher than those in pMMR CRC. Furthermore, the positive rate of CD8+TRM in tumor tissues of CRC patients in the low β-catenin expression group was higher than that in the high β-catenin expression group. Taken together, TLS and TRM cells in CRC with different Wnt classical pathway activation states and MMR subtypes could serve as a potential biomarker for the prediction of the efficacy of immunotherapy in CRC patients.
The molecular basis of psychotherapy: Focus on BDNF in talking therapies
Authors: Xu Zhi , Yao Yihan , P. Reynolds Gavin
Published: December 2024

Psychotherapy is effective in treating various types of mental disorders. However, the biological processes underlying its therapeutic efficacy in the relief of depression and anxiety remain unclear. An approach to investigating these therapeutic mechanisms derives from an understanding of disease pathogenesis, in which the dysfunction of brain-derived neurotrophic factor (BDNF) is strongly implicated. This study provides a review of various studies investigating the link between the efficacy of talking therapies in anxiety and depression and the measures of BDNF variability, the latter determined by plasma and serum BDNF concentrations, BDNF gene polymorphisms, and DNA methylation. Despite the few intriguing findings supporting the underlying hypothesis that reduced BDNF function results in poor response, many studies are limited by inadequate methodology and poor control of confounding factors. Thus, opportunities remain for further well-designed investigations, particularly utilizing the little-studied epigenetic factor of BDNF gene methylation.
Microbial involvement in myalgic encephalomyelitis/chronic fatigue syndrome pathophysiology
Authors: Borrego-Ruiz Alejandro , J. Borrego Juan
Published: December 2024

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex and disabling disease related to persistent fatigue, exercise intolerance, post-exertional malaise, cognitive dysfunction, and musculoskeletal/joint pain. Gastrointestinal comorbidities, including irritable bowel syndrome, have been reported in affected individuals, indicating a potential role of gut microbiota in disease progression. In this paper, bacterial and metabolomic dysbiosis in subjects with ME/CFS are reviewed, and phenotypic, microbial, and metabolic biomarkers specific to individual cohorts are also identified. Furthermore, microbiome fluctuations or metabolic endotoxemia are proposed as possible disorder biomarkers. Based on the fact that gut microbiota dysbiosis reverts to a state of eubiosis in long-term patients with this condition, it may be hypothesized that disease progression begins with the loss of beneficial gut microorganisms, particularly short-chain fatty acid producers, leading to more widespread gastrointestinal phenotypes that are subsequently reflected in plasma metabolite levels. These alterations, specific of each individual, thereby result in metabolic and phenotypic shifts and in ME/CFS.
Deregulation of Casein Kinase-2 in non-small-cell lung cancer: A subunit-specific analysis
Authors: Pérez George V. , Li Chen , Deng Chenyi , Yi Ying , Zhao Qiang , Zhang Zhiwei , Li Wen , Perea Silvio E. , Perera Yasser
Published: December 2024

Casein kinase-2 (CK2) is a constitutively active kinase that supports neoplastic properties. Although there is an extensive body of preclinical research on CK2, translational and clinical information remains limited and sparse. In this study, we interrogated clinical multiomics databases to examine CK2 deregulation across various cancers. Specifically, we analyzed the mutational frequency, copy-number alterations (CNA), and mRNA expression of CK2 catalytic (CSNK2A1 and CSNK2A2) and regulatory (CSNK2B) subunits across two major cancer genomic repositories (The Cancer Genome Atlas/International Cancer Genome Consortium). These genomic and transcriptomic analyses were further focused on lung cancer and complemented by in situ assessments of CK2 protein subunits and enzymatic activity in biopsies from non-small-cell lung cancer (NSCLC). Our findings indicate that gene mutations and CNA do not account for the elevated mRNA levels and enzymatic activity of CK2 subunits in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). Particularly, the upregulation of CSNK2A1 and CSNK2B mRNA was associated with a worse prognosis and showed a direct correlation with the infiltration of myeloid-derived suppressor cells in LUAD. At the protein levels, all CK2 subunits and enzymatic activity were markedly elevated in LUAD (n = 103) and LUSC (n = 31) biopsies; however, only CSNK2A1 expression correlated positively with tumor size and disease stage. Finally, CSNK2A1 appeared to be more tumor-specific than CSNK2A2, suggesting that targeted therapies against this catalytic subunit or its homotetramer may offer a more favorable therapeutic window in NSCLC.
THE IMPACT OF THE COVID-19 PANDEMIC ON THE IMPLEMENTATION OF CONSTRUCTION PROJECTS
Authors:   TECHNICAL UNIVERSITY OF CLUJ NAPOCA, POP DIANA MINODORA , RĂDULESCU CORINA MICHAELA ,   TECHNICAL UNIVERSITY OF CLUJ NAPOCA, TOADER DIANA-CEZARA ,   TECHNICAL UNIVERSITY OF CLUJ NAPOCA
Published: December 2024

The construction sector is characterized by an accentuated dynamism, which implies the rapid resolution of the numerous and different problems that arise either from the turbulence of the competitive environment or from various situations of risk and uncertainty. Unforeseen situations appeared suddenly with the outbreak of the Covid 19 pandemic, when entire human activity had to be remodeled and adapted to the new conditions. In the first months of the pandemic, the State of Emergency and then the State of Alert was implemented in all counties of the country, similar to the whole of Europe and the world, to prevent the spread of the new coronavirus. Activities in the construction sector were also disrupted by delays in the supply of raw materials. This was due to the temporary suspension of production in factories, at the beginning of the pandemic. The reduced amount of raw materials on the market also imposed an increase in prices. The present study aims to prioritize the risks and threats that influence construction projects – during the pandemic, having a significant utility in terms of the decision-making process in the implementation of construction projects.
STUDIES ON ESTABLISHING THE CONDITIONS FOR CHEMICAL CORROSION AND THE INFLUENCE OF TEMPERATURE ON THE CORROSION RATE FOR A LOW-ALLOY STEEL
Authors:   TECHNICAL UNIVERSITY OF CLUJ NAPOCA, POP AURICA
Published: December 2024

The paper presents studies conducted to establish the conditions for chemical (dry) corrosion and the influence of temperature on the corrosion rate for a low-alloy steel. Two samples of 16MnCr5 steel of different sizes are used, which are placed in an oven at different temperatures, namely 500°C (P2) and 800°C (P1). The mass variation, oxide film thickness, and corrosion rate for each sample are calculated, with these values presented in Table 2. It is observed that the oxide layer increases in thickness with longer maintenance times and higher temperatures. Additionally, the oxidation process depends on the composition of the steel and the environment in which heating occurs. The type of corrosion observed in the experiment is uniform, with the metal being uniformly destroyed over the entire surface and the corrosion products adhering well.
STUDIES ON THE ELECTROCHEMICAL CORROSION TESTING OF ALUMINUM ALLOY SERIES 7136 BY MEASURING THE VOLUME OF RELEASED GAS
Authors:   TECHNICAL UNIVERSITY OF CLUJ NAPOCA, POP AURICA
Published: December 2024

The paper presents studies conducted to determine the corrosion rate under conditions where the nature of the resulting gas is known, and the quantity of gas released is a direct measure of the amount of corroded metal. The sample used in the experiment is an aluminum alloy 7136, which is tested for corrosion by being put in contact with an electrolyte, a corrosive solution of 0.7m NaOH at pH=11. The volume of gas is read, and it is observed that the reaction proceeds rapidly immediately after the sample is introduced into the basic solution, and after 8 minutes from the initiation of the reaction, the speed is slow. The 7136 aluminum alloy sample becomes passivated; there is no longer any free surface, and a black film is observed. The volumetric corrosion index, Kv(H2), the gravimetric corrosion index, Kg, and the corrosion penetration index, P, are calculated. The results are presented in the paper, and the dependence of these indices on time is graphically represented. The sample was analyzed (after the corrosion process) with the help of a KRUSS stereoscopic microscope. Images of the surface subjected to corrosion in an alkaline solution are presented in the paper. The final analysis indicates a type of general corrosion, where the entire surface of the alloy is affected by corrosion. The general and uniform attack represents the greatest destruction of metal in terms of quantity.
PERCEPTION TOWARDS FOOD CHOICE AMONG LOW-INCOME FACTORY WORKER PARENTS OF PRE-SCHOOL CHILDREN IN NORTHERN THAILAND: A QUALITATIVE STUDY
Authors: Wungrath Jukkrit , Chanwikrai Yupa , Khumai Nuttida , Sutan Piyawat
Published: December 2024

Balanced and healthy eating habits in children may be one of the most important determinants of human health as well as good growth and development booster. Multiple factors in various contexts influence the formation of eating choices in childhood. To promote healthy food choices, it is necessary to understand the factors influencing food choices in pre-school children. Parents have been acknowledged to be an important factor impacting their children's eating habits. This study investigates parents' perspectives on children's food choices. The study was conducted utilizing in-depth interviews using two focus groups. The participants included 44 parents (32 participants and 12 additional participants) of children aged between 2 and 5 years who work in the factory and live in a rural area of Hang Chat district, Lampang province, Thailand. Participants were recruited with the assistance of CCCs staff followed the inclusion ceriterias .Participants were given a list of potential factors and asked to identify the top five factors influencing their child's eating choices. The responses were debated in a group. The discussion was recorded for later analysis. The results demonstrated that family income, child's dietary preferences, peer influence, food advertising/marketing, parental nutritional knowledge, and food availability in the markets or shops were ranked as the most influential factors. This study highlights new and essential topics for future research and may help develop parent-child interventions to improve good eating habits in pre-school children.
ASSOCIATION OF SOCIO-DEMOGRAPHIC, CLINICAL AND FEEDING CHARACTERISTICS WITH QUALITY OF LIFE AMONG CAREGIVERS OF DISABLED CHILDREN IN TERENGGANU, MALAYSIA
Authors: ISMAIL KARIMAH Fakhriah , Martine Shyerryneis Ezra , AHMAD ARYATI , HARITH SAKINAH , LUA PEI LIN , Wan Ibrahim Wan Pauzi , Wan taib Wan Rohani
Published: December 2024

Children with disabilities are dependent on caregivers. With various clinical and feeding issues with susceptibility to malnutrition, more strength, motivation and attention are required in their parenthood journey. Such special challenges may disrupt the life of the caregivers which can consequently affect their overall quality of life (QOL). This paper evaluates the association between sociodemographic factors, child’s clinical and feeding characteristics with the caregivers’ QOL. A total of 174 caregivers were involved in this cross-sectional study which was conducted in 46 community-based rehabilitation centres (CBR) across Terengganu state. The validated Malay Version World Health Organization Quality of Life-BREF (WHOQOL-BREF) questionnaire was used to assess the QOL based on four principle domains. General linear regression was applied to analyse the association between QOL impact score and study factors. The lowest QOL median score obtained was for environmental support domain 64.61 (12.26) followed by physical health domain 65.04 (12.72), psychological wellbeing domain 68.98 (13.01) and social relationship domain 75.15 (14.82). Caregivers with lower income, having children with other diseases despite current disability, experience with child seizure’s episodes and child unable to tolerate family meals had significantly lowered the caregiver’s QOL score. Both caregivers and children’s characteristics contributed to the negatively affected QOL score that consequently will contribute to the increased in the prevalence of malnutrition among disabled children.
WHY DO VILLAGERS HESITATE TO USE THE TOILET FOR DEFECATION?: AN ETHNOGRAPHIC STUDY IN DAYAK BAKUMPAI PEOPLE IN SOUTH BORNEO, INDONESIA
Authors: Indrayadi Indrayadi , Pamungkasari Eti Poncorini , Padmawati Retna Siwi , Probandari Ari
Published: December 2024

Bakumpai Dayak people, residing along the fast-flowing Barito River, have long been engaged in the practice of defecating in the river. Despite the efforts of the government to combat open defecation, this behavior has remained persistent in the community. Therefore, this study aims to explore the causes of the non-use of toilets by Bakumpai Dayak people. This was an ethnographic study, and data were collected from 11 respondents using participant observations, as well as in-depth and group interviews. The observation revealed that the community already had knowledge about hygienic toilets, but could not stop the practice of open defecation. In the area, the floating latrines employed were of various types, which were tailored to suit the specific geographical conditions of the village. Bakumpai Dayak people had a high water demand to meet their defecation, bathing, and washing needs. Furthermore, the respondents believed that floating latrines had several advantages over conventional toilets, such as the central concept of invisible stool in defecation. Based on these findings, open defecation-free status could only be achieved by implementing sanitation interventions that considered the long-standing social culture and habits of the community
An Overview of Generalized Cesàro Sequence Spaces in Geometric Calculus
Authors: Ti̇fti̇kçi̇er Meli̇sa , Güngör Ni̇han
Published: December 2024

In this study, we introduce the generalized Cesàro sequence space in geometric calculus and establish a G-modular on this space. The generalized geometric Cesàro sequence space is equipped with the Luxemburg G-norm induced by the G-modular. The connections of the G-modular and Luxemburg G-norm on this space are studied. In addition, we show that the generalized geometric Cesàro sequence space is a G-Banach space under the Luxemburg G-norm and it is G-nonsquare where pn > 1 for all n ∈ ℕ.
Development of Abdominal Oncology at the N.N. Petrov NMRC of Oncology. Dedicated to R.A. Melnikov
Authors: Гуляев Алексей Викторович , Панайотти Лидия Леонидовна , Карачун Алексей Михайлович
Published: December 2024

В статье описаны основные исторические этапы развития хирургического лечения опухолей желудочно-кишечного тракта в ФГБУ «НМИЦ онкологии им. Н.Н. Петрова» Минздрава России на базе отделения абдоминальной онкологии. Также приводится информация об основных научных исследованиях и практических нововведениях отделения и его сотрудников с момента основания и до нынешнего времени. Кроме того, отмечен вклад работников подразделения в решение основных проблем хирургического лечения опухолей желудочно-кишечного тракта. И наконец, сделан акцент на ключевые достижения наиболее выдающихся сотрудников отделения абдоминальной онкологии за всю историю его существования.
Problematic issues in the development of norms for masonry structures
Authors: Ishchuk M. K.
Published: December 2024

Introduction. In recent years, important connections between the regulatory documents on masonry structures, which were based on a system established many years ago, have been destroyed.

Aim. To identify the key issues and to outline approaches to their solution. This primarily concerns the inconsistency of State Standards on brick and mortar testing methods, as well as codes of practice for the design of masonry structures.

Results. It is shown that the strength of brick and mortar are conditional values, which depend largely on the methods of their testing, shape and size of specimens, exposure conditions prior to testing. In SP 15.13330.2012 “Masonry and reinforced masonry structures”, which is an updated version of SNiP II-22-81*, the design resistance of masonry brick and mortar grades were assigned according to the results of tests in accordance with the State Standards in force at that time. In order to restore connections with State Standards, revisions concerning the design resistance of masonry structures were introduced in SP 15.13330. This was a compromise solution. An optimal solution would be to complement the State Standard for plastic molding bricks with transition coefficients from the strength of polished bricks to the strength of bricks with a mortar-levelled surface. The types of specimens in the State Standard for masonry testing in the form of walls are borrowed from European norms. Testing walls along with columns without taking the scale factor into account leads to incorrect results.

Conclusions. Violation of the connections between State Standards for material testing methods and codes of practice for design occurs largely due to lobbying by material manufacturers, who seek to achieve the greatest benefit for themselves. Sometimes there is an unreasonable desire to interfere in the process of developing codes of practice. On the other hand, the development of high-quality regulatory documents is impossible without the involvement of a broader professional community, taking the interests of all parties into account. However, the balance of interests must not translate into the reduction of reliability of buildings and structures under construction.
НЕЛИНЕЙНАЯ ЗАДАЧА ПОИСКА ОПТИМАЛЬНЫХ УПРАВЛЯЮЩИХ ВОЗДЕЙСТВИЙ В ПРОИЗВОДСТВЕ ПРОПИЛЕНГЛИКОЛЯ
Authors: Э.А. Меликов , Т.М. Магеррамова
Published: December 2024

Пропиленгликоль широко применяется в качестве основного продукта для получения жидкого антифриза, рабочей жидкости в гидравлических системах, полиэфирных смол, а также в производстве лаков и красок, косметики, фармацевтической продукции и продуктов питания в связи с его низкой токсичностью, отсутствием цвета и запаха, хорошими смягчающими и увлажняющими свойствами. В связи с этим, получение пропиленгликоля в косметике, фармацевтике, пищевой промышленности, бытовой химии и других отраслях промышленности является актуальной задачей.
Pelatihan Literasi Keuangan dan Investasi Cryptocurrency pada Sekolah Menengah Atas Zion Makassar
Authors: Franse Franse , Pietoyo Ferryanto , Mattualy Stephany , Maichal Maichal
Published: December 2024

Pengabdian masyarakat yang dilaksanakan pada Sekolah Menengah Atas Zion Makassar merupakan bagian dari program Social Impact Challenge (SIC), yaitu kegiatan pengabdian masyarakat oleh mahasiswa dalam rangka memberikan dampak dan kontribusi positif di wilayah setempat. Tujuan kegiatan pengabdian masyarakat ini adalah mengajarkan literasi keuangan dan investasi kepada siswa-siswi SMA Zion Makassar. Kegiatan ini diinisiasi oleh Financial Club Sekolah Tinggi Ilmu Ekonomi Ciputra Makassar dengan tujuan memberikan wawasan mengenai manajemen keuangan dasar dan strategi investasi, termasuk investasi dalam cryptocurrency. Kegiatan pengabdian masyarakat ini melibatkan 17 mahasiswa yang memberikan pelatihan di enam kelas dengan total empat modulberbeda yang terdiri dari manajemen keuangan dasar, dasar dari investasi, jenis-jenis investasi, dan strategi berinvestasi. Pengabdian masyarakat ini meningkatkan minat dan ketertarikan para siswa terhadap manajemen keuangan dan investasi serta membantu para siswa memahami pentingnya literasi keuangan dan investasi.
Rethinking the Applicability of Judicial Precedents and the Sustainability of the Independence of the Judiciary in Nigeria
Authors: Ediagbonuvie Sylvester G.
Published: December 2024

This paper examines the judicial powers of the courts and the jurisdiction of the courts as provided by the Constitution of the Federal Republic of Nigeria, 1999. The paper also examines other relevant statutes to give an insight into the independence or otherwise of the Nigerian judiciary. It also highlights the doctrine of separation of powers and the rule of law as constitutional principles geared towards safeguarding the sanctity and independence of the judiciary. It further discusses the factors affecting the independence of the judiciary including judicial precedent as it affects the independence of the judiciary. It concludes that the observance of the rule of law and independence of the judiciary in ensuring the sanctity of the temple of justice is the bedrock of a democratic society.
Plasma Power Effect to the Structure and Morphology of Strontium Stannate Thin Film
Authors: Wijaya Yusmar Palapa , Mohamad Khairul Anuar , Alias Afishah , Azman Zulkifli , Ghosh Bablu Kumar , Abd Rahman Abu Bakar
Published: December 2024

Hybrid p-n heterojunction requires a suitable n-type material to support the charge transfer process in photodiode or solar cell applications. Numerous materials have been researched in terms of wet and dry processes. This paper investigated the effect of varied plasma power levels of 50 W, 80 W and 100 W at room temperature on the structure and morphology of an alkaline-earth-based perovskite oxide thin film. Strontium stannate (SrSnO3) thin films are deposited on an indium tin oxide (ITO) substrate using radio frequency (RF) magnetron sputtering at various power levels. The crystallographic orientation of the thin films was examined and it was observed that the (102) plane exhibited dense growth at low power, while the (002) plane showed increased intensity at higher power levels. Additionally, the increase in RF power resulted in larger crystallite and grain sizes, along with modified grain boundaries. Contrarily, surface roughness, resistivity, macrostrain and work adhesion were reduced. The nearly zero W-H linear fitting plot observed at 80 W can serve as a valuable reference for the fabrication of preferred films. These findings provide valuable insights for optimising the growth conditions of alkaline-earth-based perovskite oxide thin films for various applications.
Design of Low-Cost RF Detector for Electric Field Determination in Antenna Radiation Pattern Measurement
Authors: Hamzah Nurul Nazurah , Sapuan Syarfa Zahirah , Rahim Puteri Alifah Ilyana Nor , Abd Rahim Afiqah Azween , Hassan Mohd Fahrul , Amer Abdulrahman
Published: December 2024

Antenna pattern measurement is a requirement for antenna characteristics determination. However, such sophisticated set-up measurement demands skilled authority. This project employed a low-cost RF detector (MAX4003) to capture the E-field and consequently assist in acquiring data for antenna radiation pattern. By fabricating a 3.0V circuit with MAX4003 and connecting to an Arduino, this compact module creates a basic interface between the antenna under test and user’s measurement PC. The results show the measured voltage from the RF detector is in good agreement with the manufacturer’s datasheet for 1.8GHz and 2.1GHz operating frequencies. The input power is also directly proportional to the output power. The project was further tested by conducting a full 360° antenna radiation pattern measurement. The results established a satisfying comparison to theoretical radiation pattern. Overall, the system benefits to individual such as students and researchers to replicate the same method in order to have a compact and attainable antenna measurement system.
A Case Study on Ionic Compounds on the Aluminium 6061 Surface during Etching and Passivating Processes
Authors: Zulkurnain Muhammad Nasiruddin , Osman Shahrul Azmir , Ourdjini Ali , Osman Saliza Azlina
Published: December 2024

The surface treatment process for aluminium is extensive, encompassing many methods and techniques. This study utilises chemical etching and passivation chemicals as surface treatment processes for chemical cleaning. The corrosion-controlled procedure involves the application of a powerful etchant solution to eliminate undesirable layers of material. Additionally, passivation chemicals are utilised as coatings to enhance the corrosion resistance of aluminium surfaces. Following the chemical cleaning process, ion chromatography testing was conducted to verify the ionic compounds on the surface of the aluminium metal subsequent to its reaction with etching and passivation chemicals. Different approaches were employed to address the ionic compound deposition problem on the surface of aluminium 6061 metal. Results revealed that replacing existing chemicals with new ones is the best solution to reduce the reading below the specified limit. However,  one economically viable alternative for the chemical cleaning process is implementing an aeration process during rinsing, which offers greater economic efficiency compared to the substitution of chemicals entirely. Besides that, chemical cleaning via aeration procedure can mitigate the accumulation of ionic compounds on the material's surface.
CFD Analysis of the Choledynamic Flow Characteristics of a Patient with Gallbladder Carcinoma
Authors: Lavilles Francis Dominic , Dela Cruz Wendell Ace , Doma Bonifacio Jr
Published: December 2024

Gallbladder carcinoma (GBC) is a rare malignancy with a low detection rate due to non-specific symptoms, complicating early diagnosis and treatment. This study aims to improve pre-operative and post-operative surgical analysis using patient-specific CFD analysis. CT scan images of a male patient with GBC were segmented using 3D Slicer software, and the biliary tree geometry was imported into ANSYS Workbench for fluid and solid meshing. The mechanical properties of the biliary tree and the rheological properties of bile were determined, with an LRN k-ω model used for simulating the gallbladder refilling stage. Results indicate that unhealthy bile flows slower than healthy bile, suggesting a link between obstructed bile flow and tumors or stones. Tumor-induced blockages cause pressure accumulation in the gallbladder neck, unlike the minimum pressure in healthy cases. These findings highlight the complex interplay between bile rheology, tumor development, and pressure dynamics, suggesting the model’s potential use in surgical planning.