bluuebunny/crossref_metadata_2025 huggingface dataset:
Химический состав листьев вахты трехлистной
Authors: Турусова Елена В. , Александрова Луиза Николаевна , Лыщиков Анатолий Николаевич , Насакин Олег Евгеньевич
Published: April 2021

Методом атомно-абсорбционной спектрометрии исследован микроэлементный состав листьев вахты трехлистной в различные периоды формирования растения. Установлено, что в период цветения наблюдается незначительная биоаккумуляция Fe, Cu и Zn. Кроме того, установлено незначительное увеличение содержания физиологически активных соединений (иридоидов, полифенолов и аскорбиновой кислоты) в период формирования растения. Причем содержание иридоидов и аскорбиновой кислоты выше в образцах вахты трехлистной, произрастающей на экологически благополучной территории. Высокое же содержание полифенольных соединений в исследуемых образцах, скорее, обусловлено присутствием в них элементов-биофилов, таких как Cu, Zn, Mn и Fe.
Местноанестезирующая активность и острая токсичность комбинированного геля в эксперименте
Authors: Филатова Альбина Васильевна , Тураев Аббас Собирханович , Выпова Наталья Леонидовна
Published: April 2021

Приведены результаты исследования местноанестезирующей активности геля для поверхностной анестезии, разработанного в Институте биоорганической химии им. акад. А. С. Садыкова Академии наук Республики Узбекистан. В качестве препаратов сравнения использовали гель ДФ Скинкаин (Корейская Республика) и 5 % раствор лидокаина. На модели терминальной анестезии роговицы глаза кролика показано, что испытуемый гель обладает местноанестезирующим действием: индекс Ренье равен 950, в то время как у препарата сравнения ДФ Скинкаин он составляет 680, у 5 % раствора лидокаина — 480. В сравнении с гелем ДФ Скинкаин новый гель обладает более продолжительным анестезирующим действием (75 ± 6,4 против 45 ± 3,8 мин, или продолжительнее на 66,7 %) и более коротким латентным периодом (4 против 6 мин, или меньше на 37 %). Проведенные исследования показали, что инстилляция в конъюнктивальный мешок нового геля не вызывает негативных местных реакций. Напротив, использование в качестве анестезирующего агента 5 % раствора лидокаина приводит к появлению признаков местного раздражения в виде гиперемии конъюнктивы и края век. Результаты исследования острой токсичности при подкожном введении мышам показали, что анестезирующий гель в 7 раз менее токсичен, нежели 5 % раствор лидокаина. Показатель LD50 препаратов составил: лидокаин 274,6 ± 7,4 мг/кг, ДФ Скинкаин ≥ 2000 мг/кг, новый анестезирующий гель ≥ 2500 мг/кг.
Разработка метода количественного определения производного бензимидазола, соединения с лабораторным шифром РУ-31, проявляющего противомигренозную активность в биологических пробах
Authors: Смирнова Людимила Андреевна , Рябуха Анна Федоровна , Кузнецов Константин Александрович , Великопольская Мария Владимировна , Спасов Александр Алексеевич , Яковлев Дмитрий Сергеевич
Published: April 2021

Разработан метод количественного определения лекарственной субстанции РУ-31 — производного метоксифенилимидазо[1,2- a]бензимидазола, проявляющего противомигренозную активность, в биологических пробах. Данный метод обладает достаточной селективностью и высокой чувствительностью, что позволяет использовать его для проведения фармакокинетических исследований данного соединения. Чувствительность метода (предел обнаружения) для изучаемого соединения составляет 100 нг/мл, предел количественного определения — 500 нг/мл. Средняя ошибка измерения не превышает 15 %.
CAS Versos
Authors: Souza Claudio Alexandre de
Published: April 2021

Sempre acreditei no poder das palavras: palavras cantadas, faladas, pensadas, enfim, acredito na potência com que elas podem tocar os corações, acolher, emocionar, motivar, incentivar e materializar os sentimentos mais íntimos de cada ser humano. Às vezes, as palavras mais fascinantes aparecerão em uma boa conversa, em uma música ou em um livro como este que reúne as reflexões de um pensador que ousa dar asas à imaginação e colocar em versos, de uma forma leve e cativante, os seus sentimentos em relação ao amor, à vida, à amizade e à existência humana. Em relação ao fazer poético, o próprio autor menciona: “Poeta? Talvez. Ou apenas alguém que permite ao universo se manifestar por meio das palavras”. E que boas palavras! As palavras aqui contidas propiciam momentos de deleite e de reflexão que emocionam e acariciam o coração daqueles que permitem se levar pelo toque invisível e inebriante das palavras poéticas! Boa leitura! Wilma Maria Pereira
Ensinando com tecnologias digitais nos primeiros anos escolares
Authors: Porfírio Luciana Cristina , Santos Iara Santana dos
Published: April 2021

The study sought to investigate the limits and possibilities of the use of TDIC as pedagogical resources for the teaching and learning process in the early years of elementary school from a broad literature focused on its use as a tool for teaching work in which the importance of using TDIC in the early years of elementary school and in the initial and continuing training of teachers. To this end, the methodology used in the research were bibliographic sources of qualitative nature from the socialhistorical cultural perspective, i.e., one that seeks to understand a given phenomenon from a given context, establishing a dialogical relationship between the individual, the society and their historical and cultural processes. It presents a descriptive account of the methodological process developed, by which it could be concluded that the TDIC is already part of people’s daily lives and the school has the cultural function of teaching the so-called digital students - those born in the midst of the TDIC culture. From the mobilized literature it was also evident that, although the TDIC are used to enhance teaching and learning, there is a lack in the teacher’s curriculum training courses and also in the school’s infrastructure to the insertion and integration of those technologies in the school culture.
História da Educação: Sujeitos na/da história - Vol. I
Authors: Jinzenji Mônica Yumi , Lages Rita Cristina Lima
Published: April 2021

This collection unites results of academic works concluded within the span of 2016 to 2020 in the field of History of Education for the Programa de Pós-Graduação em Educação da Faculdade de Educação da Universidade Federal de Minas Gerais. Comprised of two volumes, this first volume is made up of 17 chapters analyzing education from historical perspectives, and spanning from the XVIII to the XXI century. The first part of the book brings together studies highlighting women’s protagonism either perceived as a social body or as specific personas. The second part of the book unites studies about authors, works or even about the printing process as well as researchers’ interest for such area of study. The third part of the book brings together works about individuals and educational processes given the historical, cultural and social contexts taking place during educational practices at play both inside as well as outside schools.
The Strategy of The Republic of Indonesian Government in Dealing with Covid-19 Pandemic from the Perspective of Total War Strategy
Authors:   Indonesia Defense University, Indonesia, Budi Budi , Anwar Syaiful
Published: April 2021

The Covid-19 pandemic demands the Indonesian Government to act against the various impacts caused through various strategies and efforts. The spread of the Covid-19 pandemic is very fast, resulting in many casualties, not only the wider community but also health workers who carry out tasks throughout the country. The existence of the Covid-19 pandemic has also affected the political, economic and almost all sectors of life, including defense. In order to discuss the problem of the Covid-19 Pandemic, supporting theories are used, namely strategy theory, pandemic theory, universal defense theory and universal war strategy theory. The method used in the analysis of the Covid-19 pandemic is a qualitative descriptive phenomenology, that is, with the existing phenomena regarding Covid-19 and qualitatively explaining the data obtained from literature studies to gain an understanding of strategies for dealing with it. The results of the analysis found that there were various supporting factors and obstacles to handling efforts, implementing strategies, among others, to increase understanding of Covid-19, then preventive steps by using the next application of governance for handling Covid-19 and increasing a strong community superstructure. The aim of the strategy undertaken is to inhibit the spread and countermeasures from a Total War Strategy perspective.
The Effect of Expository and Cooperative Learning Strategies on Student Learning Result in Class X Office Governance Automation of State Vocational High School I Palembang
Authors:   Universitas Muhammadiyah Palembang (Indonesia), Samsilayurni Samsilayurni , Sasongko Rambat Nur ,   Universitas Bengkulu (Indonesia), Kristiawan Muhammad ,   Universitas Bengkulu (Indonesia)
Published: April 2021

The purpose of this study was to determine the effect of expository learning strategies and cooperative learning strategies that can affect student learning result in archiving subjects in class X Office Governance Automation of Vocational High School 1 Palembang. The total population of 96 students, the 96 students were sampled in this research. This research technique is by conducting observations, questionnaires and documentation. This study consisted of three variables X1, namely expository learning strategy, cooperative learning strategy variable X2. Then variable Y student learning results. Based on the results of the ANOVA test or F test, the results of the study show that H0 is rejected and Ha is accepted, meaning that there is a significant effect of X1 expository learning strategy and X2 cooperative learning strategy together on student Y learning result in Archives class X Office Governance Automation Middle School subjects. Vocational State I Palembang. It is recommended that educators make efforts to make improvements and improve the quality of the teaching and learning process in order to obtain better learning result. Therefore, appropriate learning strategies are needed to realize effective learning.
Developing Critical Thinking Skills in Elementary School Students Through Foreign Language Education: An Action Research
Authors:   Marmara University (Turkey), Sarıcan Elif , GÜNEŞ Ecenur Büşra ,   Akasya College (Turkey)
Published: April 2021

People constantly practice the act of thinking. They may not think about everything, yet they certainly think of something and make decisions. Critical thinking is a sort of reflective thinking. It is controlled and aimed at perfect thinking. It enables the self-realization of individuals in social life. Therefore, it is important to develop critical thinking at school stages and early ages. The purpose of this research was to investigate “the effect of foreign language learning activities on critical thinking skills of 4th-grade students”. To achieve this purpose, researchers tried to answer these questions: (1) What is the effect of critical thinking activities on students’ critical thinking? (2) What is the effect of critical thinking activities on students’ personal definitions of critical thinking and critical thinker? (3) What is the effect of critical thinking activities on students’ social skills? The method of this research is action research which is considered highly important for educational sciences. In the course of this research, activities for developing critical thinking skills were implemented to 4th grade students. 25 4th grade private elementary school students participated in the research. Researchers used 13-question “Critical Thinking Skill Open-ended Questionnaire” to collect data. The answers given to the open-ended questionnaire before and after the activities were analyzed using content analysis, and themes and codes were determined accordingly, thereby answers of the students are compared. It is noted that before implementation, most of the students did not have any idea about critical thinking or they thought critical thinking has a negative connotation; however, after implementation, they gained more positive and open-minded opinions about this term.
THE QUALITY OF POLLEN GRAINS IN WHEAT MATURE ANTHERS OF ZHNITSA CULTIVAR IN PLANTA CONDITIONS
Authors:   Ufa Institute of Biology of the Ufa Federal Research Centre of the Russian Academy of Sciences, Zinatullina A.E.
Published: April 2021

Biotechnological and selection investigations for making of wheat high-yielding resistant varieties require a significant amount of high-quality mature pollen. It is important to assess It is important to assess the quality of pollen grains in mature anthers in planta of the wheat genotypes included in the experiments. In the course of research the analysis of the histological status of mature anthers was carried out and qualitative cytological evaluation inside them pollen grain of spring soft wheat Zhnitsa cultivar was done in in planta conditions. It was shown that the structure of the wall locule anther presented by exothecium and endothecium is typical for cereals. It was established that 3-cell mature pollen grains are fertile (87-92%) and viable (75–80%) in general. At the same time in every mature anther abnormal pollen grains were observed and the cellular, nuclear, cytoplasmic and architectonic deviations from the norm were revealed. On the base of literature date the analysis of the reasons for the formation of abnormal pollen grains in planta was done and the classification of anomalies of plant pollen grains and the terminology used in this field of research were discussed.
INFLUENCE OF FLURIDONE ON THE CONTENT OF HORMONES IN CALL OF BARLEY CV. STEPTOE AND TS ABA‑DEFICIENT MUTANT AZ34
Authors:   Ufa Institute of Biology of the Ufa Federal Research Centre of the Russian Academy of Sciences, Seldimirova O.A. , Galin I.R. ,   Ufa Institute of Biology of the Ufa Federal Research Centre of the Russian Academy of Sciences
Published: April 2021

The effect of the inhibitor of endogenous ABA synthesis fluridone on the content and distribution of endogenous ABA and IAA in the calli of ABA-deficient mutant AZ34 barley and its parental cultivar Steptoe was studied using the methods of immuno-enzymatic solid-phase assay and immunolocalization of phytohormones. It was found that by the 4th week of in vitro culture, fluridone causes a significant decrease in the ABA level in calli of both genotypes compared to the control, and the inhibitory effect of fluridone in AZ34 is more pronounced than in Steptoe. In the calli of both genotypes, a significant increase in the IAA content was revealed against the background of a decrease in the ABA content upon treatment with fluridone as compared to the control. It was concluded that ABA plays an important role in the process of embryoido-genesis in vitro.
Produksi Biogas dari Limbah Black Water dan Kotoran Ternak Menggunakan Reaktor Upflow Anaerobic Sludge Blanket (UASB)
Authors: Wardhani P. K. , Amizera S. , Prima F. H.
Published: April 2021

Penelitian ini bertujuan untuk menginvestigasi produksi biogas serta efisiensi penyisihan BOD, COD, TSS, dan keberadaan organisme patogen (E. coli) dari limbah black water dan kotoran ternak menggunakan reaktor Upflow Anaerobic Sludge Blanket (UASB) pada temperatur mesofilik (28 - 30 C). Hasil penelitian menunjukkan bahwa efisiensi penyisihan COD, TSS, dan BOD sebesar 67,8 %, 92, 5 %, dan 36, 9 %. Biogas yang dihasilkan pada hari ke 7, hari ke 14 dan hari ke 21 meliputi 12 %, 51 %, dan 64 % untuk metan, sementara karbon dioksida sebesar 21 %, 34 %,  dan 33 %. Hal ini menunjukkan bahwa pengolahan limbah black water dan kotoran ternak secara anaerobik dapat diterapkan dengan menggunakan reaktor UASB. Selain itu, pengolahan limbah black water dan kotoran ternak secara anaerobik dengan reaktor UASB memberikan manfaat yang besar dalam menghasilkan metan.
Pemberian Konsentrat Mengandung Tepung Biji dan Kulit Durian Fermentasi terhadap Produksi dan Kualitas Susu serta MIOFC pada Sapi Perah
Authors: Sulistyowati E. , Priyono B. S. , Titania D. , Setiaji Y. , Rahayu A.
Published: April 2021

Tujuan dari aplikasi ini untuk mengevaluasi konsentrat mengandung tepung biji durian dan kulit durian fermentasi terhadap produksi dan kualitas susu serta milk income of feed cost (MIOFC) pada sapi perah. Hasil aplikasi pemberian konsentrat mengandung tepung biji durian menghasilkan produksi susu yang lebih tinggi (8,93l/ekor/hari) dibanding perlakuan lainnya.  Konsentrat dengan tepung biji durian membutuhkan biaya ransum terendah  (Rp.17.507,35/ekor/hari), menghasilkan penerimaan susu tertinggi (Rp.89.275,00/ekor/hari) dan MIOFC tertinggi (Rp.71.767,60/ekor/hari).  Namun, ransum dasar (tanpa konsentrat tepung biji durian dan kulit durian fermentasi) tetap yang efisien karena tidak menggunakan konsentrat sehingga biaya ransum lebih rendah; sementara, produksi susu hampir sama dengan konsentrat tepung biji durian.
Higgs-Meson and Higgs-Gluon Interaction and Mass Acquiring Mechanism
Authors: Hu Wan-Chung
Published: April 2021

The mass acquiring mechanism of meson or gluon is discussed in this article. Higgs-meson interaction and Higgs-gluon interaction are the key mechanism. Finally, we can get the mass origin of neutron or proton. The detail deduction is provided in the manuscript. We can get same mass of charged pions, neutral pion, charged gluons, and neutral gluons. This article solves the mass gap problem of Yang-Mills theory.
Weight gradience and stress in Portuguese
Authors: Garcia Guilherme D.
Published: April 2021

This paper examines the role of weight in stress assignment in the Portuguese lexicon, and proposes a probabilistic approach to stress. I show that weight eﬀects are gradient and monotonically weaken as we move away from the right edge of the word. Such eﬀects depend on the position of a syllable in the word as well as the number of segments the syllable contains. The probabilistic model proposed in this paper is based on a single predictor, namely, weight, and yields more accurate results than a categorical analysis, where weight is treated as binary. Finally, I discuss implications for the grammar of Portuguese.
Indonesia's Ready To Rise And Compete Globally
Authors: anna aprilya
Published: April 2021

If Indonesia wants to do this, then Indonesia must have employees who are competitive and also have high competitiveness with other countries. The factors that support a good employee organization are providing a large salary or intensive and a work environment that makes all employees feel comfortable while working at a company. For example, the automotive industry. In this industry, of course, it is necessary to develop a technology that is practically unceasing. Employees must continue to learn related to the latest technologies and also keep abreast of the times. The methods that have been done are technology that can print three dimensions and also the robotic system. These various ways are done so that the automotive industry works more efficiently and quickly.
Genome editing can now be carried out in an isogenic setting, CRIS has great potential as a medical promise.
Authors: Dowaidar Moataz
Published: April 2021

As a result of genome editing, the field of cardiovascular research and treatmentis changing. Related variants can now be introduced into patient-derived cellsand tested in an isogenic environment. To evaluate the safety and efficacy ofgene-editing therapeutics, cellular phenotyping of genome-edited iPSC-derivedcardiomyocytes and other cell types will be invaluable. Parallel to theseadvances, viral vectors and nanoparticles can be used to efficiently edit genes inthe liver and core. Somatic gene editing has been used to treathypercholesterolemia, hypertriglyceridemia, WPW syndrome,catecholaminergic polymorphic ventricular tachycardia, and Duchennemuscular dystrophy in animal models. While these early achievements arepromising, they have also shown major challenges. Off-target editing withCRISPR/Cas systems will be influenced by the same editing enzyme,architecture, target cell type, and delivery mechanism. It is possible to transmitefficiently to somatic tissues in mice, but not all delivery pathways scale well tohumans. On-target unintentional editing operations, such as major deletions andinsertions, require further analysis and risk evaluation. Immunity, as well as thesubsequent development of an immune response to the Cas9 protein extractedfrom bacteria, will necessitate caution. Despite these reservations, CRISPR/Cashas tremendous therapeutic promise, and it is expected to enhance research andmedical treatment in the future.
PROGRAM SKRINING PADA KASUS TUBERKULOSIS
Authors: Novitasari Alfira , Rahingrat Angsoka
Published: April 2021

Tingginya angka kasus Tuberkulosis di Indonesia menjadi penyebab diberlakukannya skrining TB yang dibutuhkan bagi pasien yang mengalami gejala (TB aktif) atau memiliki kondisi tertentu yang dapat meningkatkan risiko TB.
Studi Kasus: Asuhan Keperawatan Jiwa pada Ny. S Dengan Masalah Halusinasi Pendengaran
Authors: Simatupang Sarah Monica
Published: April 2021

Halusinasi merupakan keadaan seseorang mengalami perubahan dalam pola dan jumlah stimulasi yang diprakarsai secara internal atau eksternal disekitar dengan pengurangan, berlebihan, distorsi, atau kelainan berespon terhadap setiap stimulus
Genetic and epigenetic discoveries hold promising avenues in cardiovascular disorders prevention and management by using gene therapy.
Authors: Dowaidar Moataz
Published: April 2021

These recent genetic and epigenetic discoveries hold promising avenues incardiovascular prevention and management (CVDs) Currently, key nucleic acidsare being researched and developed for medicinal use. The trial was onlydesigned to be to an extent that would satisfy the demands ofbiopharmaceutical/industrial development.determinants in clinical trials, and of ASO and siRNA previously developedantisense oligonucleotides for cardiovascular disease. Advanced nucleic acidchemistry produces nucleic acid compounds that maintain key structuralattributes of RNA or DNA. Modifications of the backbone also improved thedrug-receptor specificity and decreased protease activityASOs for Apo (a) targeting Lp (a) and the production of other similar therapiesare currently available or will soon be available. It is a second-generation ASOcalled Volens which has been approved in Europe for chylothoriamiasiscontributing to hemangiomas and rheumatoidensisitum rather than to treatprotein CVD. TASO produces a significant reduction in wild-type and mutantTTR ASO options that target dystrophy have been evaluated in humans.Both siRNA and CRISPR have a long, long history, but these protection aspectsneed to be worked out first. (currently) of concern: chemically synthesized siAs,recombinanted si an RNA-induced silencing complex (RISC) utilizes Argona(A) to synthesize siRNAs
The Development of eLEMA-SCL Protozoa for Invertebrate Zoology Courses
Authors: Haryono Agus , BASUKI BEJO , ADAM CHAIDIR , SAVITRI SHANTY , ARAINA ELGA , FAHRINA RIRIN
Published: April 2021

The development of electronic learning materials is very necessary in the midst of the COVID-19 pandemic which requires lecture activities to be carried out online. This was carried out to support physical distancing in an effort to break the chain of transmission of COVID-19. Currently, there are not many electronic learning materials available that lead to student centered learning (SCL) and can be implemented in the midst of the COVID-19 pandemic. The purpose of this research is to develop an eLEMA (Electronic Learning Material) application, an Android-based electronic learning material with content or material that can be accessed online and offline, and with features that make it easier for users to operate. This research is a research development (Research and Development; R & D) to develop Android-based ELEMA-SCL PROTOZOA (Electronic Learning Material-Student Centered Learning) for Zoology courses. This development model consists of 3 phases of approach, namely: (1) Phase 1: Needs Assessment; (2) Phase 2: Design; and (3) Phase 3: Develop / Implement. The product developed in the form of an Android-based eLEMA application made using the MIT App Inventor is feasible to implement. The implementation results show: (1) the effectiveness of online and offline lectures with a gain value of 0.52 in the Medium category; (2) student response to the implementation of eLEMA is positive. Thus the eLEMA application can be used for online and offline lectures during the COVID-19 pandemic.
Measurement of Competitiveness and Market Concentration of Indonesian Banking Sharia
Authors: Paulina
Published: April 2021

This study aims: (1) The extent of competitiveness of sharia banking in Indonesia's current economic development; (2) How far the strength of the sharia banking market in Indonesia today. The research conducted to measure the competitiveness of sharia banking in Indonesia and market forces encountered, using the observation period 2010-2016, and the data used is time series and cross section data. The research design used in research is quantitative research, by using model Lerner Index, PR-H Statistics Model, and multiple regression. Based on the results of the study, 1. Using the Lerner index model, for 10 Indonesian sharia banks, especially murabahah products with observation period 2010 - 2016, shows that the competitiveness of Indonesian sharia banks is still very low. The Lerner index for each sharia banks with competitiveness of murabahah products is Bank Mega Sharia, Bank BRI Sharia, Maybank and BSM. As for other sharia banks is still very low; 2. The measurement of market forces using the PR-H Statistics model, murabahah products of Indonesian sharia banks during 2010-2016 fall into the category of the monopolistic competition market. This indicates that, the murabahah product of each sharia banks is basically almost the same, only slightly differentiated by the deficited products in such a way between one bank and another bank; 3. Regression result model of factors affecting competitiveness, only ROA variable that influence to competitiveness, it shows that ROE variable, capitalization and efficiency not become determinant of competitiveness of a bank, especially for murabahah product.
The therapeutic application of a nucleic acid sequence to patients' diseased organs is currently available.
Authors: Dowaidar Moataz
Published: April 2021

The therapeutic application of a nucleic acid sequence to patients' diseasedorgans or tissues is currently being studied in a Phase 1/2 human trial forfamilial hypercholesterolemic homozygosity. In the year 2025, the FDA has fiveto ten green drugs for clinical production, with proven progress. Luxturn andZolgensma have paved the way for a new method for treatment of hereditaryRPE65 and SMN-deficient retinal and spinal muscular dystrophy. It seems thatrAAV vectors are a hard organ to target, and therefore allow therapeutic genetherapy in the heart to be a concern. The discovery of other cardiac targets suchas S100A1/GRK2 inhibitors could be wise, although simple/efficient deliverysystems are being developed. The CRIS-dependent hypertrophiccardiomyopathy (mg) caused by the MYBPC3 mutation may be corrected usinghuman germline CRIS9 in stem cells, however. The investigation of non-codingDNA and epigenetics has increased the number of treatments available. Nucleictreatments can be used as a first-line treatment if pharmacotherapotherapieshave failed.
Chờ đột phá thể chế từ tân Thủ tướng
Authors: Si H.L. Cu
Published: April 2021

Phó Giáo sư, Tiến sĩ Trần Đình Thiên gọi ngay cho tôi khi vừa mới xuống sân bay Nội Bài, sau chuyến công tác vào Thành phố Hồ Chí Minh. Đề tài chúng tôi nói là về tân Thủ tướng Chính phủ Phạm Minh Chính vừa được kỳ họp cuối cùng của Quốc hội khóa 14 thông qua.
Genome-wide association studies (GWAS) have revolutionized our view of human health and disease genetics and offered novel gene therapy targets
Authors: Dowaidar Moataz
Published: April 2021

Knowing how genetic, behavioural, and sociocultural factors influence eachperson's risk for C. It is imperative that a larger, more diverse set of geneticstudies be done in order to be able to close the analysis of CMD distance Interms of disease prevention, there is a lot of interest in CMD genomic research.This potential can only be achieved if Ancestry DNA-style data like PRS issuccessfully gathered from the population. Inadequate participation is a bigissue in current CMD genetic research. Differential minorities in the UnitedStates and Canada have set forth some important steps to improve their accessto genetic research. To make sure that this will not happen again, these activitiesinclude discovering the issues and using community-based participatoryinterventions and benefits-sharing mechanisms. People underrepresented in theworld of genetics will require more services to support them.CMD and other genomics markers have been successfully identified and creatednovel avenues for human and population health change. In addition, it hascomplicated matters with regard to how this data would affect the broaderhealthcare system. What are the main questions: disproportionate difficulty inthe CMD genotype-phenotype database; confounded research on diseaseheritability; ethnicity may not be well described, making estimating diseaseheritability difficultDespite these roadblocks, genome-informed inclusive datawill bear unprecedented promise for bringing down CMD and improvingwellbeing. A large-scale data unification has already occurred, as mentioned inthis blog post to CMD Data sharing, however, is a project that must be done ona small scale in order to gain initial traction. This is also applicable to GWASresearch on self-identified ethnicity. Although race and ethnicity are sociallyand culturally constructed, the use of self-identifying categories in geneticstudies still endures.
Emergence of computers in manga : from public to private sphere, from optimistic futurism to widespread uncritical adoption.
Authors: Akmut Camille
Published: April 2021

Broad trends in the representation of computer technology in manga historyare described, This analysis is based on major, works of the medium, (Umezu’sclassic horror The Drifting Classroom to Umaru-chan’s last volume), both pio-neering and uncertain, covering roughly the period from 1970 to 2020.
Meningkatkan kualitas daya saing dalam bisnis online
Authors: Arianti Widya
Published: April 2021

Bisnis online merupakan bisnis yang sangat muda di lakukan dengan cukup memamfaatkan media sosial yang ada seperti facebook, instagram, WhatsApp serta media sosial lainnya. Dalam upaya menjalankan bisnis online, meningkatkan daya saing merupakan salah satu faktor yang perlu diperhitungkan. Hal tersebut berkaitan dengan peran UMKM dalam pertumbuhan ekonomi nasional. Daya saing dalam bisnis online dapat diwujudkan dengan penggunaan teknologi informasi untuk meningkatkan transformasi bisnis, ketepatan dan efisiensi pertukaran informasi, selain itu penggunaan teknologi informasi juga dapat mempeluas jaringan pemasaran. Permasalahan yang dikaji dalam penelitian ini adalah Bagaimana meningkatkan kualitas bisnis online Penelitian ini bertujuan untuk mengetahui apakah metode 3M yang dilakukan untuk meningkatkan kualitas bisnis online mampu meningkatkan perkembangan usaha dan Untuk mengetahui apakah metode 3M dapat meningkatkan kualitas daya saing
Mutmainnah
Authors: Mutmainnah
Published: April 2021

Proses belajar mengajar di sekolah memerlukan strategi atau model pembelajaran yang mampu meningkatkan kemampuan peserta didik baik dalam hal intelegency maupun kemampuan pemecahan masalah . salah satu model pembelajaran yang diterapkan di sekolah yaitu Problem Based Learning (PBL) merupakan salah satu model pembelajaran yang mampu menunjang kemampuan pemecahan masalah dan dengan adanya pembelajaran berbasis masalah ini mampu mendorong peserta didik dalam berpikir kreatif ,kritis dan analitis serta penalaran menyelesaikan masalah dan menginteprasikan dalam kehidupan. Problem based learning atau pembelajaran berbasis masalah menempatkan peserta didik sebagai pusat dalam proses pembelajaran dengan mengajukan berbagai maslah yang kiranya mampu mengembangan pemahaman dan penalaran peseta didk dalam penyelesaian masalah matematis. Sehingga dapat disimpulkan bahwa problem based learning perlu diimplementasikan dalam pembelajaran yang mampu meningkatkan mutu pendidikan.
Analogue Weather in a Digital World: On the Value of Integrating Both the Physical and the Technological in Day-to-day Experiences of Weather
Authors: Stewart Alan E. , Bolton Matthew J.
Published: April 2021

Smartphones, tablets, and computers offer a wealth of digital information about the world and have transformed the ways we live. Our experiences of the world are now so much more mediated by digital devices than ever before. This is especially the case for living with (and under) the influences of our weather and climate. Here, we explore the idea that an ongoing digitalization of weather and climate, vis-à-vis technology, and the evolving discourse about them may be minimizing or obscuring the actual phenomenological experiencing of weather and climate. We first discuss trends in the digital portrayal of weather and climate and then contrast these with embodied experiences of the weather which, together with “old-school” physical observation techniques, we refer to as an analogue experiencing of the weather. In the third section, we discuss the value of integrating both digitalized and analogue experiences of the weather. Finally, we introduce some ways to become more attuned to the weather of one’s place while locating these experiences on the larger landscape of data and digitalized meteorology.
Developmental Relations between Mathematics Anxiety, Symbolic Numerical Magnitude Processing, and Arithmetic Skills from First to Second Grade
Authors: Mononen Riikka , Niemivirta Markku , Korhonen Johan , Lindskog Marcus , Tapola Anna
Published: April 2021

We investigated the levels and changes in mathematics anxiety (MA), symbolic numerical magnitude processing (SNMP) and arithmetic skills, and how those changes are linked to each other. Children’s (n = 264) MA, SNMP and arithmetic skills were measured in Grade 1, and again in Grade 2, including also a mathematics performance test. All three constructs correlated significantly within each time point, and the rank-order stability over time was high, particularly in SNMP and arithmetic skills. By means of latent change score modeling, we found overall increases in SNMP and arithmetic skills over time, but not in MA. Most interestingly, changes in arithmetic skills and MA were correlated (i.e., steeper increase in arithmetic skills was linked with less steep increase in MA), as were changes in SNMP and arithmetic skills (i.e., improvement in SNMP was associated with improvement in arithmetic skills). Only the initial level of arithmetic skills and change in it predicted mathematics performance. The only gender difference, in favour of boys, was found in SNMP skills. The differential effects associated with MA (developmentally only linked with arithmetic skills) and gender (predicting only changes in SNMP) call for further longitudinal research on the different domains of mathematical skills.
Individuals expend more effort to compete against robots than humans after observing competitive human-robot interactions
Authors: Timmerman Rosanne , Hsieh Te-Yi , Henschel Anna , Hortensius Ruud , Cross Emily S.
Published: April 2021

In everyday life, we often observe and learn from interactions between other individuals –– so-called third-party encounters. As robots are poised to become an increasingly familiar presence in our daily lives, third-party encounters between other people and robots might offer a valuable approach to influence people’s behaviours and attitudes towards robots. Here, we conducted an online experiment where participants (n = 48) watched videos of human-robot dyads interacting in a cooperative or competitive manner. Following this observation, we measured participants’ behaviour and attitudes towards the human and robotic agents. First, participants played a game with the agents to measure whether their behaviour was affected by their observed encounters. Second, participants’ attitudes toward the agents were measured before and after the game. We found that the third-party encounters influenced behaviour during the game but not attitudes towards the observed agents. Participants showed more effort towards robots than towards humans, especially when the human and robot agents were framed as competitive in the observation phase. Our study suggests that people’s behaviours towards robots can be shaped by the mere observation of third-party encounters between robots and other people.
Coevolution of actions, personal norms, and beliefs about others in social dilemmas
Authors: Gavrilets Sergey
Published: April 2021

Human decision-making is affected by a diversity of factors including material cost-benefit considerations, normative and cultural influences, learning, and conformity with peers and external authorities (e.g., cultural, religious, political, organizational). Also important are their dynamically changing personal perception of the situation and beliefs about actions and expectations of others as well as psychological phenomena such as cognitive dissonance, and social projection. To better understand these processes, I develop a modeling framework describing the joint dynamics of actions and attitudes of individuals and their beliefs about actions and attitudes of their group-mates. I consider which norms get internalized and which factors control beliefs about others. I predict that the long-term average characteristics of groups are largely determined by a balance between material payoffs and the values promoted by the external authority. Variation around these averages largely reflects variation in individual costs and benefits mediated by individual psychological characteristics. The efforts of an external authority to change the group behavior in a certain direction can, counter-intuitively, have an opposite effect on individual behavior. I consider how various factors can affect differences between groups and societies in tightness/looseness of their social norms. I show that the most important factors are social heterogeneity, societal threat, effects of the authority, cultural variation in the degree of collectivism/individualism, the population size, and the subsistence style. My results can be useful for achieving a better understanding of human social behavior, historical and current social processes, and in developing more efficient policies aiming to modify social behavior
PENDETEKSI GANGGUAN TV KABEL BERBASIS MIKROKONTROLER DAN SMARTPHONE
Authors: Efendi Akhmad , Ulum Miftachul , Ibadillah Achmad Fiqhi , Laksono Deni Tri
Published: April 2021

Para pengguna pada sistem televisi kabel seringkali mengeluh jika terjadi gangguan berupa kualitas gambar yang tidak jernih atau bahkan hilang, sehingga membutuhkan bantuan teknisi untuk memperbaiki gangguan. Teknisi dituntut untuk sigap dalam menyelesaikan gangguan yang terjadi pada layanan tv kabel, sehingga perlu untuk segera mengetahui jenis gangguan di pelanggan yang berada di tempat yang jauh. Salah satu cara untuk mengatasinya adalah dengan memberikan notifikasi kepada provider jika terdapat gangguan. Pemberian sensor pada amplifier gambar setiap jalur yang dapat mengirimkan notifikasi berupa data kepada provider yang dapat dipantau secara jarak jauh. Alat yang dikembangkan terdiri dari sensor tegangan dan arus, mikrokontroler  dan ESP826601. Alat yang dikembangkan mampu mengirimkan gangguan berupa tegangan dan arus dan dapat dipantau melalui smartphone.
THE RESULTS OF THE PROGRAM OPTIMIZATION OF THE MOTIVATIONAL-SEMANTIC SPHERE FOR PATIENTS WITH DIABETES
Authors: Krupelnytska Liudmyla Frantsivna  , Burovska Iryna Oleksandrivna
Published: April 2021

The article shows the approbation results of the program optimization of the motivational-semantic sphere for patients with diabetes mellitus. The main content of the program and the results of the research are presented using the test "Meaning and life orientations" by D. Leontiev, the method "Diagnosis of the motivational structure of personality" by V. Milman and "The color test of attitudes" by A. Etkind. The study involved 79 people, mean age - 55.86, σ - 16.72. There is an increase in indicators of motives for communication and community usefulness that provide compensation for socio-psychological problems caused by the disease; goals in life, process and locus of control-I. These changes can be considered as markers of optimization of the motivational and semantic sphere of these persons. In the comparison group, the changes differ significantly from the changes in the main group: the indicators of the motive for communication, goals in life and the locus of control-I have increased. But there is a paradoxical combination of the locus of control-I growth with a simultaneous significant decrease in the locus of control-life. It can be explained, on the one hand, by improving physical condition and, accordingly, expanding the perspective of Future of these people, on the other hand, strengthening the belief that their somatic well-being depends on other people and circumstances, not on themselves. Disease’s emotional assessment intensity, under the psychocorrection program influence, decreased in the main group, while, on the contrary, there was simultaneous increasement in the comparison group. Emotional evaluation of the Present for respondents from the main group increased after the program; on the contrary, for those in the comparison group, this indicator decreased. The value of the Future in both groups increased for the first week of stay in the treatment center, but growth was more intense for the main group.
LEGISLATIVE PROBLEM OF EXCLUDING A PARTNER FROM THE COMPANY ON THE EXAMPLE OF GEORGIA (COMPARATIVE ANALYSIS)
Authors: Ketevan Kokrashvili  , Lasha Gorgadze
Published: April 2021

The issue of excluding a partner (removing a partner) from the company is one of the most important, very sensitive and controversial issues in corporate law. The legislation of different countries regulates this issue in different ways, but it is important that most countries, together with the decision of the General Meeting of Partners, to exclude a partner, require a relevant court decision that has entered into legal force. On the basis of a comparative analysis, the presented article discusses the possible reasons for the exclusion of a partner and the issues of legal regulation of the exclusion procedure. The fiduciary duties of a partner are analyzed as one of the important reasons for the exclusion of a partner from the company. Special attention is paid to legislative gaps and to the heterogeneity of the case law of Georgia in connection with the exclusion of a partner from the company. However, the article discusses the shortcomings of the new draft law of Georgia on Entrepreneurs, it is worth mentioning that the draft law was developed on the basis of the Association Agreement between Georgia and the European Union. Under this agreement, Georgia undertook an obligation to integrate Georgian corporate law into EU corporate law, in addition, in our opinion, the positions presented in the article will significantly develop and improve such an important institution of corporate law as the exclusion of a partner from the company.
CİZRE İSMAİL EBUL-İZ EL-CEZERİ MÜZESİ’NDE BULUNAN BİR GRUP MADENİ İBRİK
Authors: ERK Ahmet
Published: April 2021

İnsan ihtiyacının bir sonucu olarak ortaya çıkan el sanatları, tarih boyunca yaşamış toplumların bir aynasıdır. Dolayısıyla el sanatları ürünleri, ait olduğu toplumun karakteristik özelliklerini yansıtan önemli ögelerin başında gelmektedir. Bu ögelerin önemli bir gurubunu da ibrikler oluşturmaktadır. İbrikler temizlenme, su taşıma ve sıvı maddeleri saklamak gibi kullanımlarının yanı sıra, bazı dinî ritüelleri yerine getirmek için de tarih boyunca farklı toplumlar tarafından kullanıldığı bilinmektedir. İbrikler, işlevsel özelliklerinden dolayı ilk başta ortaya çıkmış olsalar da zaman içinde farklı kullanım alanlarına da sahip olmuştur. Bu çalışmada stratejik bir öneme sahip Cizre ilçesinin kadim tarihîne değinilerek, Cizre İsmail Ebul-İz El-Cezeri Müzesi’nde bulunan bir grup madenî ibrik tanıtılmıştır. Form, malzeme, süsleme ve yapımında kullanılan teknikler açısından ele alınan ibrikler, sanat tarihi metodolojisine uygun bir biçimde analiz edilmeye çalışılmıştır.
Prostate Artery Embolisation as a Palliative Care in a Patient with Prostate Cancer: A Case Report
Authors: B. Nerli R. , B. Nerli R. , Adhikari Priyabrata , Mulimani Naveen , Bidi Saziya , Rangrez Shadab , Chandra Shreya , C. Ghagane Shridhar
Published: April 2021

Introduction: Prostate artery embolization is an emerging technique, that appears to be a promising option in the management of benign prostatic hyperplasia for patients unsuitable for surgery. Prostate artery embolization, similar to all other interventions, is not a suitable treatment for all patients with this disease. It is indicated as a minimally invasive option in patients unfit to undergo trans urethral resection of prostate.
Case Report: A 78-year-old male suffering from castrate resistant prostate cancer and on treatment with Abiraterone plus prednisolone presented to the Uro-oncological services of the hospital with difficulty to void, incomplete voiding, and sense of incomplete voiding. He had other medical co-morbidities which included Diabetes mellitus, hypertension, and ischaemic heart disease. His cardiac ejection fraction was 25% and was advised not to undergo any surgical procedure. Serum creatinine on admission was 2.2 mg% and serum PSA were 26.5 ng/ml. Under local anaesthesia, using retrograde Seldinger’s technique right common femoral arterial access was obtained and 6F vascular introducer sheath was placed. Bilateral pelvic angiogram was performed, each of the prostatic arteries was superselectively catheterized and the prostatic gland was embolized using PVA (polyvinyl alcohol) particles 200m. Post catheter removal the patient voided well with a maximum flow of 14.5 ml/sec.
Conclusion: Prostate artery embolization can successfully treat complications associated with prostate cancer such as LUTS, urinary retention and haematuria with a low risk of serious adverse events.
Green Growth Is Trusted To Fix Climate Change
Authors: Skopec Robert
Published: April 2021

'Greening' our current economic system can only take us so far. GTS/Shutterstock You may have missed it, but a recent report declared that the main strategy of world leaders for tackling climate change won’t work. It’s called green growth, and it’s favoured by some of the largest and most influential organisations in the world, including the United Nations and the World Bank.