bluuebunny/crossref_metadata_2025 huggingface dataset:
Follicular DNA Damage and Pesticide Exposure Among Latinx Children in Rural and Urban Communities
Authors: Lepetit Cassandra , Gaber Mohamed , Zhou Ke , Chen Haiying , Holmes Julia , Summers Phillip , Anderson Kim A. , Scott Richard P. , Pope Carey N. , Hester Kirstin , Laurienti Paul J. , Quandt Sara A. , Arcury Thomas A. , Vidi Pierre-Alexandre
Published: November 2023

The intersectional risks of children in United States immigrant communities include environmental exposures. Pesticide exposures and their biological outcomes are not well characterized in this population group. We assessed pesticide exposure and related these exposures to DNA double-strand breaks (DSBs) in Latinx children from rural, farmworker families (FW; N = 30) and from urban, non-farmworker families (NFW; N = 15) living in North Carolina. DSBs were quantified in hair follicular cells by immunostaining of 53BP1, and exposure to 72 pesticides and pesticide degradation products were determined using silicone wristbands. Cholinesterase activity was measured in blood samples. DSB frequencies were higher in FW compared to NFW children. Seasonal effects were detected in the FW group, with highest DNA damage levels in April–June and lowest levels in October–November. Acetylcholinesterase depression had the same seasonality and correlated with follicular DNA damage. Organophosphate pesticides were more frequently detected in FW than in NFW children. Participants with organophosphate detections had increased follicular DNA damage compared to participants without organophosphate detection. Follicular DNA damage did not correlate with organochlorine or pyrethroid detections and was not associated with the total number of pesticides detected in the wristbands. These results point to rural disparities in pesticide exposures and their outcomes in children from vulnerable immigrant communities. They suggest that among the different classes of pesticides, organophosphates have the strongest genotoxic effects. Assessing pesticide exposures and their consequences at the individual level is key to environmental surveillance programs. To this end, the minimally invasive combined approach used here is particularly well suited for children.
Significant relationship between musculoaponeurotic attachment of the abdominal and thigh adductor muscles to the pubis: implications for the diagnosis of groin pain
Authors: Tharnmanularp Suthasinee , Muro Satoru , Nimura Akimoto , Ibara Takuya , Akita Keiichi
Published: November 2023

Groin pain is prevalent in orthopedic and sports medicine, causing reduced mobility and limiting sports activity. To effectively manage groin pain, understanding the detailed anatomy of supporting muscles is crucial. This study aimed to investigate the musculoaponeurotic attachments on the pubis and the relationship among intramuscular aponeuroses of abdominal and thigh adductor musculatures. Macroscopic analyses were performed in 10 pelvic halves. The bone morphology of the pubis was assessed in two pelvic halves using microcomputed tomography. Histological investigations were conducted in two pelvic halves. The external oblique aponeurosis extended to the adductor longus aponeurosis, forming conjoined aponeurosis, which attached to a small impression distal to the pubic crest. The gracilis aponeurosis merges with the adductor brevis aponeurosis and is attached to the proximal part of the inferior pubic ramus. The rectus abdominis and pyramidalis aponeuroses were attached to the pubic crest and intermingled with the gracilis-adductor brevis aponeurosis, forming bilateral conjoined aponeurosis, which attached to a broad area covering the anteroinferior surface of the pubis. Histologically, these two areas of conjoined aponeuroses were attached to the pubis via the fibrocartilage enthesis. Microcomputed tomography revealed two distinctive bone morphologies, a small impression and an elongated osseous prominence on pubis, corresponded to the two areas of conjoined aponeuroses. This study demonstrated close relationships between the aponeurotic attachment of the external oblique and adductor longus, and between the rectus abdominis, pyramidalis, gracilis, and adductor brevis. The findings of aponeurotic complexes would aid in diagnostic and surgical approaches for athletic groin pain.
Which Meditation Technique for Whom? An Experimental Single-Case Study Comparing Concentrative, Humming, Observing-Thoughts, and Walking Meditation
Authors: Matko Karin , Sedlmeier Peter
Published: November 2023

Objectives

Meditation encompasses a variety of techniques, but little is known on how and for whom they work. This study explored potential mechanisms of four different meditation techniques in beginners and which technique might be suited for whom.

Method

Using an experimental single-case design, we compared the longitudinal effects of concentrative, humming, observing-thoughts, and walking meditation. Forty-four healthy participants without meditation experience were randomly assigned to one of the four techniques and 42 completed the treatment. Following a baseline period of 2 to 4 weeks, participants learned and practiced their technique 20 min daily for 6 to 8 weeks and completed daily online questionnaires throughout the entire study period. At pretest, we assessed participants’ motivation and personality. We analyzed the data visually and by conducting single-case meta-analyses, correlation, and multivariate analyses.

Results

Body awareness, decentering, and emotion regulation improved reliably and continuously over time, for all four techniques. Thus, these processes could represent common mechanisms for novice meditators. Walking meditation led to the smallest improvements in decentering and mind-wandering, but the highest in body awareness and emotion regulation. Individuals varied in response to the treatment. The two “classic” techniques (concentration, observing-thoughts) led to more consistently positive multivariate response patterns and to better responses in participants high in neuroticism. In contrast, those high in extraversion benefitted more from the two unusual ones (humming, walking). We additionally observed interesting interactions with different motivational reasons.

Conclusions

With this study, we hope to contribute to theory building and answering two urgent questions—what the key mechanisms of meditation are and who benefits most from what kind of practice.
Pan-cancer analyses of senescence-related genes in extracellular matrix characterization in cancer
Authors: Yan Bo , Liao Pan , Shi Liqiu , Lei Ping
Published: November 2023

Purpose

The aged microenvironment plays a crucial role in tumor onset and progression. However, it remains unclear whether and how the aging of the extracellular matrix (ECM) influences cancer onset and progression. Furthermore, the mechanisms and implications of extracellular matrix senescence-related genes (ECM-SRGs) in pan-cancer have not been investigated.

Methods

We collected profiling data from over 10,000 individuals, covering 33 cancer types, 750 small molecule drugs, and 24 immune cell types, for a thorough and systematic analysis of ECM-SRGs in cancer.

Results

We observed a significant correlation between immune cell infiltrates and Gene Set Variation Analysis enrichment scores of ECM-SRGs in 33 cancer types. Moreover, our results revealed significant differences in immune cell infiltration among patients with copy number variations (CNV) and single nucleotide variations (SNV) in ECM-SRGs across various malignancies. Aberrant hypomethylation led to increased ECM-SRGs expression, and in specific malignancies, a connection between ECM-SRGs hypomethylation and adverse patient survival was established. The frequency of CNV and SNV in ECM-SRGs was elevated. We observed a positive correlation between CNV, SNV, and ECM-SRGs expression. Furthermore, a correlation was found between the high frequency of CNV and SNV in ECM-SRGs and poor patient survival in several cancer types. Additionally, the results demonstrated that ECM-SRGs expression could serve as a predictor of patient survival in diverse cancers. Pathway analysis unveiled the role of ECM-SRGs in activating EMT, apoptosis, and the RAS/MAPK signaling pathway while suppressing the cell cycle, hormone AR, and the response to DNA damage signaling pathway. Finally, we conducted searches in the “Genomics of Drug Sensitivity in Cancer” and “Genomics of Therapeutics Response Portal” databases, identifying several drugs that target ECM-SRGs.

Conclusions

We conducted a comprehensive evaluation of the genomes and immunogenomics of ECM-SRGs, along with their clinical features in 33 solid tumors. This may provide insights into the relationship between ECM-SRGs and tumorigenesis. Consequently, targeting these ECM-SRGs holds promise as a clinical approach for cancer treatment.
Practices of Knowledge Exchange in the Context of the COVID-19 Pandemic
Authors: Peschke Lutz , Gyftopoulos Sotirios , Kapusuzoğlu Ayhan , Folkvord Frans , Gümüş Ağca Yasemin , Kaldoudi Eleni , Drosatos George , Ceylan Nildağ Başak , Pecchia Leandro , Güneş Peschke Seldağ
Published: November 2023

This paper contributes to a better understanding of a system of pandemic knowledge exchanges. Therefore, three different case studies conducted in Germany, Greece, and Turkiye and executed in multiple countries were analyzed in the context of Mode 3 knowledge production and the Quintuple Helix system. While the Quintuple Helix system describes the knowledge exchange processes between the systems of science, economy, politics, public, and natural environment of societies for sustainable innovation processes, Mode 3 emphasizes the importance of a creative environment for research and innovation. The COVID-19 pandemic revealed that the need for knowledge exchange with the media-based public increased dramatically. In both models, Mode 3 and the Quintuple Helix but also in the Design Thinking approach, the creative environment incorporates the knowledge of the media-based public. Nonetheless, the reality of the public is constructed as media reality. Therefore, a mix of evidence-based and opinion-based knowledge is produced and transferred during knowledge exchange in the context of innovation processes including public engagement. It could be understood that the mediating entities media and general practitioners have a similar double function in the context of knowledge exchange with the public during the pandemic times. The results reveal the big need for knowledge communication and exchange platforms which on the one hand strengthen citizen participation by transforming opinion-based into evidence-based content. On the other hand, reach the status of a global standard medium for the pandemic knowledge exchange accepted by all stakeholders of the Quintuple Helix. This generates a shared-knowledge environment with a gain for all systems of the Quintuple Helix during the sustainable innovation processes.
Guided Play Supporting Immigrant Children’s Participation and Bilingual Development in Preschools
Authors: Cekaite Asta , Simonsson Maria
Published: November 2023

In recent decades, refugee immigration has had significant impact on educational contexts in Sweden, with preschools the primary arenas for young children’s language learning experiences. The present study examines second language and literacy training practices for immigrant children (aged 1–5) in preschools in Sweden. The empirical data consist of video recordings of teacher-guided play activities. These were designed to create rich linguistic and cultural environments facilitating active and democratic participation by the children. Guided play activities were developed in close collaboration between teachers and researchers during action-based interventions that were aimed at constructing child-oriented participatory language learning practices in ethnically and linguistically diverse ECEC settings. The children’s first languages were Tigrinya, Arabic dialects, Somalian, Kurdish dialects, Russian, Spanish and Swedish. The participatory learning potential of guided play was collaboratively analyzed and assessed, and new and revised activities were implemented, based on the goals of inclusivity and children’s active engagement in play and language learning. The analysis shows that teachers’ use of multimodal semiotic means, such as questions, texts and cultural artifacts (stories, material story-related objects, play spaces) were important strategies for the preparation of appealing play environments and activities that contributed to children’s curiosity and participation. These resources served as affordances for guided play, allowing the simultaneous scaffolding of children’s play competencies and their language learning.
On the Material Constitutive Behavior of the Aortic Root in Patients with Transcatheter Aortic Valve Implantation
Authors: Catalano Chiara , Turgut Tahir , Zahalka Omar , Götzen Nils , Cannata Stefano , Gentile Giovanni , Agnese Valentina , Gandolfo Caterina , Pasta Salvatore
Published: November 2023

Background

Transcatheter aortic valve implantation (TAVI) is a minimally invasive procedure used to treat patients with severe aortic valve stenosis. However, there is limited knowledge on the material properties of the aortic root in TAVI patients, and this can impact the credibility of computer simulations. This study aimed to develop a non-invasive inverse approach for estimating reliable material constituents for the aortic root and calcified valve leaflets in patients undergoing TAVI.

Methods

The identification of material parameters is based on the simultaneous minimization of two cost functions, which define the difference between model predictions and cardiac-gated CT measurements of the aortic wall and valve orifice area. Validation of the inverse analysis output was performed comparing the numerical predictions with actual CT shapes and post-TAVI measures of implanted device diameter.

Results

A good agreement of the peak systolic shape of the aortic wall was found between simulations and imaging, with similarity index in the range in the range of 83.7% to 91.5% for n.20 patients. Not any statistical difference was observed between predictions and CT measures of orifice area for the stenotic aortic valve. After TAVI simulations, the measurements of SAPIEN 3 Ultra (S3) device diameter were in agreement with those from post-TAVI angio-CT imaging. A sensitivity analysis demonstrated a modest impact on the S3 diameters when altering the elastic material property of the aortic wall in the range of inverse analysis solution.

Conclusions

Overall, this study demonstrates the feasibility and potential benefits of using non-invasive imaging techniques and computational modeling to estimate material properties in patients undergoing TAVI.
Automated lead toxicity prediction using computational modelling framework
Authors: Chaurasia Priyanka , McClean Sally I. , Mahdi Abbas Ali , Yogarajah Pratheepan , Ansari Jamal Akhtar , Kunwar Shipra , Ahmad Mohammad Kaleem
Published: November 2023

Background

Lead, an environmental toxicant, accounts for 0.6% of the global burden of disease, with the highest burden in developing countries. Lead poisoning is very much preventable with adequate and timely action. Therefore, it is important to identify factors that contribute to maternal BLL and minimise them to reduce the transfer to the foetus. Literacy and awareness related to its impact are low and the clinical establishment for biological monitoring of blood lead level (BLL) is low, costly, and time-consuming. A significant contribution to an infant’s BLL load is caused by maternal lead transfer during pregnancy. This acts as the first pathway to the infant’s lead exposure. The social and demographic information that includes lifestyle and environmental factors are key to maternal lead exposure.

Results

We propose a novel approach to build a computational model framework that can predict lead toxicity levels in maternal blood using a set of sociodemographic features. To illustrate our proposed approach, maternal data comprising socio-demographic features and blood samples from the pregnant woman is collected, analysed, and modelled. The computational model is built that learns from the maternal data and then predicts lead level in a pregnant woman using a set of questionnaires that relate to the maternal’s social and demographic information as the first point of testing. The range of features identified in the built models can estimate the underlying function and provide an understanding of the toxicity level. Following feature selection methods, the 12-feature set obtained from the Boruta algorithm gave better prediction results (kNN = 76.84%, DT = 74.70%, and NN = 73.99%).

Conclusion

The built prediction model can be beneficial in improving the point of care and hence reducing the cost and the risk involved. It is envisaged that in future, the proposed methodology will become a part of a screening process to assist healthcare experts at the point of evaluating the lead toxicity level in pregnant women. Women screened positive could be given a range of facilities including preliminary counselling to being referred to the health centre for further diagnosis. Steps could be taken to reduce maternal lead exposure; hence, it could also be possible to mitigate the infant’s lead exposure by reducing transfer from the pregnant woman.
Food stimuli decrease activation in regions of the prefrontal cortex related to executive function: an fNIRS study
Authors: Cheng Chen , Yang Yong
Published: November 2023

Purpose

Overweight/obese individuals show impairments in executive functions such as inhibitory control. However, the neural mechanisms underlying these disturbances—and specifically, whether or not they involve altered activation of the specific prefrontal cortex regions—are not yet fully understood.

Methods

The motivational dimensional model of affect suggests that high approach-motivated positive affect (e.g., desire) may impair executive function. In the present study, we investigated individual differences in neural responses to videos of food stimuli, and examined brain activity during a cognitive task in an approach-motivated positive state using functional near-infrared spectroscopy (fNIRS). In Experiment 1, in 16 healthy young adults, we tested whether prefrontal cortex activation differed during a food video clip versus a neutral video clip. Then, after viewing each video clip, we tested for differences in executive function performance and prefrontal cortex activation during a Stroop task. Experiment 2 was the same, except that we compared 20 overweight/obese with 20 healthy young adults, and it incorporated only the food video clip.

Results and conclusions

The results of both experiments indicated that food stimuli decrease activation in regions of the prefrontal cortex related to executive function. This study also suggests that overweight/obese might consciously suppress their responses to a desired stimulus, yet here it seems that effect was less pronounced than in healthy controls.

Level of evidence

Level II, Cohort Studies.
From Liquid to Solid-State Lithium Metal Batteries: Fundamental Issues and Recent Developments
Authors: Zhang Zhao , Han Wei-Qiang
Published: November 2023

The widespread adoption of lithium-ion batteries has been driven by the proliferation of portable electronic devices and electric vehicles, which have increasingly stringent energy density requirements. Lithium metal batteries (LMBs), with their ultralow reduction potential and high theoretical capacity, are widely regarded as the most promising technical pathway for achieving high energy density batteries. In this review, we provide a comprehensive overview of fundamental issues related to high reactivity and migrated interfaces in LMBs. Furthermore, we propose improved strategies involving interface engineering, 3D current collector design, electrolyte optimization, separator modification, application of alloyed anodes, and external field regulation to address these challenges. The utilization of solid-state electrolytes can significantly enhance the safety of LMBs and represents the only viable approach for advancing them. This review also encompasses the variation in fundamental issues and design strategies for the transition from liquid to solid electrolytes. Particularly noteworthy is that the introduction of SSEs will exacerbate differences in electrochemical and mechanical properties at the interface, leading to increased interface inhomogeneity—a critical factor contributing to failure in all-solid-state lithium metal batteries. Based on recent research works, this perspective highlights the current status of research on developing high-performance LMBs.
A Time Series Decomposition and Reinforcement Learning Ensemble Method for Short-Term Passenger Flow Prediction in Urban Rail Transit
Authors: Wu Jinxin , He Deqiang , Li Xianwang , He Suiqiu , Li Qin , Ren Chonghui
Published: November 2023

Short-term passenger flow prediction (STPFP) helps ease traffic congestion and optimize the allocation of rail transit resources. However, the nonlinear and nonstationary nature of passenger flow time series challenges STPFP. To address this issue, a hybrid model based on time series decomposition and reinforcement learning ensemble strategies is proposed. Firstly, the improved arithmetic optimization algorithm is constructed by adding sine chaotic mapping, a new dynamic boundary strategy, and adaptive T distribution mutations for optimizing variational mode decomposition (VMD) parameters. Then, the original passenger flow data containing nonlinear and nonstationary irregular changes of noise is decomposed into several intrinsic mode functions (IMFs) by using the optimized VMD technology, which reduces the time-varying complexity of passenger flow time series and improves predictability. Meanwhile, the IMFs are divided into different frequency series by fluctuation-based dispersion entropy, and diverse models are utilized to predict different frequency series. Finally, to avoid the cumulative error caused by the direct superposition of each IMF’s prediction result, reinforcement learning is adopted to ensemble the multiple models to acquire the multistep passenger flow prediction result. Experiments on four subway station passenger flow datasets proved that the prediction performance of the proposed method was better than all benchmark models. The excellent prediction effect of the proposed model has important guiding significance for evaluating the operation status of urban rail transit systems and improving the level of passenger service.
Graph Neural Network-Based Short‑Term Load Forecasting with Temporal Convolution
Authors: Sun Chenchen , Ning Yan , Shen Derong , Nie Tiezheng
Published: November 2023

An accurate short-term load forecasting plays an important role in modern power system’s operation and economic development. However, short-term load forecasting is affected by multiple factors, and due to the complexity of the relationships between factors, the graph structure in this task is unknown. On the other hand, existing methods do not fully aggregating data information through the inherent relationships between various factors. In this paper, we propose a short-term load forecasting framework based on graph neural networks and dilated 1D-CNN, called GLFN-TC. GLFN-TC uses the graph learning module to automatically learn the relationships between variables to solve problem with unknown graph structure. GLFN-TC effectively handles temporal and spatial dependencies through two modules. In temporal convolution module, GLFN-TC uses dilated 1D-CNN to extract temporal dependencies from historical data of each node. In densely connected residual convolution module, in order to ensure that data information is not lost, GLFN-TC uses the graph convolution of densely connected residual to make full use of the data information of each graph convolution layer. Finally, the predicted values are obtained through the load forecasting module. We conducted five studies to verify the outperformance of GLFN-TC. In short-term load forecasting, using MSE as an example, the experimental results of GLFN-TC decreased by 0.0396, 0.0137, 0.0358, 0.0213 and 0.0337 compared to the optimal baseline method on ISO-NE, AT, AP, SH and NCENT datasets, respectively. Results show that GLFN-TC can achieve higher prediction accuracy than the existing common methods.
Imagination und Erfahrung
Authors: Bernard Andreas
Published: November 2023

Dieser Essay beschäftigt sich mit dem Verhältnis von Imagination und Erfahrung in gegenwärtigen poetologischen Debatten. Es geht um die vieldiskutierte Frage, welche Autorensubjekte welche literarischen Darstellungen hervorbringen können und sollen. Der Essay versucht diese aktuellen Positionen in der Geschichte der literarischen Hermeneutik seit Dilthey zu verorten.
»Soviel Gegenwart war selten.«
Authors: Amlinger Carolin
Published: November 2023

Der Beitrag beobachtet in dem Phänomen des Debattenromans einen neuen Bearbeitungsmodus von Ungewissheit. Außerliterarische Wertigkeiten der Aktualität sollen eine Kommensurabilität zwischen fiktiven Erfolgserwartungen von Büchern und realisierten Beachtungserfolgen öffentlicher Debatten herstellen. Mit ähnlichen Wertigkeitsprüfungen wird die Germanistik konfrontiert, die angesichts messbarer Beachtungsverluste mithilfe heteronomer Valorisierungen auf ihre Gegenwärtigkeit hin befragt wird.
The history of fire blight biocontrol with Gram-negative bacteria and bacteriophages
Authors: Puławska Joanna , Mikiciński Artur , Sobiczewski Piotr
Published: November 2023

Fire blight caused by bacterium Erwinia amylovora is one of the most damaging diseases of apple and pear trees and many other plant species of the Rosaceae family. So far, it has been detected in almost all areas of pome fruit cultivation and in some regions it causes economic damage every year. Plant protection against fire blight is aimed at both preventing their infection and controlling the disease. However, the protection of plants against bacteriosis is generally difficult due to the small range of plant protection products and the growing doubts about their safety for the environment. Limitations related to their use have resulted in an increased interest in alternative methods, including the method of biological protection using various microorganisms. The first research on biological control agents was conducted in the USA about 100 years ago. Currently, it is also carried out in other countries, especially where fire blight causes economic losses. Commercial products whose active ingredients are mainly bacteria have already been developed. This work is a review of the studies and achievements in this field from its beginnings focusing on the Gram-negative bacteria and bacteriophages as a biocontrol agents.
Pedological factors as drivers of archaeal and fungal communities in maize rhizosphere: a shotgun metagenomic sequencing approach
Authors: Akinola Saheed Adekunle , Ayangbenro Ayansina Segun , Babalola Olubukola Oluranti
Published: November 2023

South Africa is a semi-arid country in need of soil conservation methods for sustainable agroecosystem practices. Over time, researchers have worked extensively on the plant growth beneficial effects of fungi. However, archaeal groups in the soil and rhizosphere of different plants are under-studied. The impact of soil edaphic factors on the community structure of archaeal and fungal groups in the maize rhizosphere is the focus of this research. This will confirm the hypothesis that environmental factors have a significant impact on the plant–soil rhizobiome. To achieve this objective, a shotgun metagenomics approach was used to analyze maize rhizosphere and bulk soils collected from North West and Gauteng provinces of South Africa. Our findings revealed that both the maize rhizosphere and bulk soils have several archaeal and fungal phyla in common. Besides, Ascomycota (30‒51%), Thaumarchaeota (14‒26%), Euryarchaeota (19‒29%), and Crenarchaeota (8‒12%) have significantly dominated the maize rhizosphere and surrounding bulk soils. In comparison, genera such as Nitrosopumilus (Ls-18.32%, Lc-16.25%; Rs-15.45%, Rc-11.47%), Candidatus Nitrososphaera (Ls-15.29%, Lc-13.37%; Rs-10.53%, Rc-8.29%), Cenarchaeum (Ls-8.84%, Lc-8.16%; Rs-7.63%, Rc-5.38%), Chaetomium (Ls-25.15%, Lc-23.05%; Rs-14.83%, Rc-6.29%), and Neurospora (Ls-2.09%, Lc-1.95%; Rs-1.05%, Rc-0.99%) were significantly higher in maize rhizosphere soils compared to bulk soils (p < 0.05). Diversity indices showed that the archaeal and fungal composition were significantly different across samples with the presence of unclassified groups that could indicate the possibility of novel organisms in the sampling areas. The forward selection of soil edaphic factors predicted N–NH4, pH, and organic matter as the major contributing factors to the variation in the fungal and archaeal communities. To fully exploit the advantages possessed by these species, it is necessary to better understand the main environmental factors driving microbial assemblages of the soil microbiome. In addition, mapping out a culture-based method to unveil the unclassified groups could assist in the discovery of biotechnologically important archaeal and fungal groups for sustainable plant growth.
Cracking the code: mapping residential building energy performance in rural Central Asia through building typologies
Authors: Mehta Kedar , Zörner Wilfried
Published: November 2023

Buildings in rural Central Asia have unique characteristics as they were built during the Soviet era (during 1950–1960) without any energy efficiency measures. The special and aged building stock pose a crucial challenge on energy security and energy supply. However, accurate scientific data on their energy usage is lacking, highlighting a research gap about robust and validated methodology to determine the energy use of rural Central Asian buildings. In response to this need, this research paper proposes a set of generalised residential building typologies for rural Central Asia, with a focus on Kyrgyzstan. The study combines quantitative and qualitative methods, including household surveys, energy demand modelling, EnergyPlus simulations, and result validation. It derives energy-based building typologies from construction year and building envelope characteristics. Through numerous validated simulations, it was identified that the heat demand for rural Kyrgyz houses is 3–5 times here compared to European houses (250–400 kWh/m2). The study revealed the estimated heat demand for homes in rural Kyrgyzstan, indicating a significant potential for improving building energy efficiency in the region. These results can inform specific approaches, such as building renovation plans, energy certification, and renovation strategies. Furthermore, the validated methodology introduced offers opportunities for researchers in the field of building energy efficiency and can be applied to similar regions in Central Asia with comparable building stocks and climates.
Intraindividual Fluctuation in Optimism Under Daily Life Circumstances: A Longitudinal Study
Authors: Shimomura Kanji , Morita Kenji , Nishiguchi Yuki , Huffman Jeff C. , Millstein Rachel A.
Published: November 2023

Optimism is typically conceptualized as a relatively static tendency regarding positive expectations about one’s future. However, recent studies suggest that optimism may meaningfully fluctuate within individuals over time. To date, little is known about the characteristics of such state optimism and potential cultural difference in state optimism. Accordingly, we developed a Japanese version of the State Optimism Measure (J-SOM) and examined its validity and the nature of intraindividual state optimism fluctuations; we also examined relationships between the J-SOM and other measures of mental health, including trait optimism. We conducted two online longitudinal surveys with different time intervals (weekly, n = 97; monthly, n = 99) targeting university students. Results were largely consistent between the two surveys. We confirmed high factor validity and internal consistency of the J-SOM. The J-SOM showed significant correlations in expected directions with other measures such as depressive mood and subjective happiness. In addition, intraindividual changes in the J-SOM were associated with changes in mood and quality of daily life. Importantly, these associations between intraindividual change in optimism and in other variables were minimal for trait optimism. We also found that state optimism, compared with trait optimism, tended to show larger intraindividual changes over 1, 2, 3, 4, and 8 weeks. In summary, this study developed a translated version of the SOM and validated it, and then showed, for the first time, that state optimism can fluctuate within individuals in daily life over a span of several weeks.
Emerging posttranslational modifications and their roles in DNA damage response
Authors: Wu Zhen , Liu Yajing , Zhang Meng , Wang Donglai
Published: November 2023

Posttranslational modifications (PTMs), occurring on various histones and nonhistone proteins, greatly enrich the diversity of the proteome, thereby profoundly affecting protein structures and biological functions. Histones are particularly important components of genomic chromatin and their modifications represent a critical event in the control of DNA damage response (DDR) induced by endogenous or exogenous insults. Extensive studies have revealed the roles of classical PTMs including phosphorylation, acetylation and ubiquitination, in modulating chromatin dynamics through the recruitment of chromatin remodeling complex and repair machinery during DDR process, thus successfully maintaining genome stability and preventing the cells from adverse fates such as apoptosis or malignant transformation. In recent years, several novel PTMs, such as ufmylation, crotonylation, succinylation and lactylation, have been discovered on both histones and nonhistone proteins. Their potential roles and regulatory mechanisms during DDR process have indeed emerged, but are still far from completely understood. This review primarily focuses on the regulation of novel PTMs in DDR, and further discusses the repair networks of cell in response to DNA damage and the interplay between diverse modifications in DNA damage response, which aims to expand the understanding of PTMs involved in DDR regulation and provides potential insights into disease intervention.
On reading and interpreting black box deep neural networks
Authors: Dobson James E.
Published: November 2023

The deep neural networks used in computer vision and in recent large language models are widely recognized as black boxes, a term that describes their complicated architectures and opaque decision-making mechanisms. This essay outlines several different strategies through which humanist researchers and critics of machine learning might better understand and interpret the class of deep learning methods known as Transformers. These strategies expose different aspects of what might be “learned” as Transformers are trained and used in the analysis of language and can help critics at least partially open the black box of machine learning. They are also especially useful for digital humanists using these models as part of a research program informed by tool criticism in which the use of computational tools is conceived of as a metainterpretive act.
COMMONSIM: Simulating the utopia of COMMONISM
Authors: Gerdes Lena , Aigner Ernest , Meretz Stefan , Pahl Hanno , Schlemm Annette , Scholz-Wäckerle Manuel , Schröter Jens , Sutterlütti Simon
Published: November 2023

This research article presents an agent-based simulation hereinafter called COMMONSIM. It builds on COMMONISM, i.e. a large-scale commons-based vision for a utopian society. In this society, production and distribution of means are not coordinated via markets, exchange and money, or a central polity, but via bottom-up signalling and polycentric networks, i.e. ex ante coordination via needs. Heterogeneous agents care for each other in life groups and produce in different groups care, environmental as well as intermediate and final means to satisfy sensual-vital needs. Productive needs decide on the magnitude of activity in groups for a common interest, e.g. the production of means in a multi-sectoral artificial economy. Agents share cultural traits identified by different behaviours: a propensity for egoism, leisure, environmentalism and productivity. The narrative of this utopian society follows principles of critical psychology and sociology, complexity and evolution, the theory of commons and critical political economy. The article presents the utopia and an agent-based study of it, with emphasis on culture-dependent allocation mechanisms and their social and economic implications for agents and groups.
Body Fat Distribution, Fat-Free Mass and Cardiovascular Function in the UK Biobank
Authors: Oguntade Ayodipupo S. , Lacey Ben , Taylor Hannah , Lewington Sarah
Published: November 2023

Background

We evaluated the independent associations of body composition measures on left ventricular ejection fraction (LVEF) and pulse wave arterial stiffness index (PWASI).

Methods

The present analysis included 23,258 individuals (mean age 63 years, 53% women) who participated in the whole body imaging sub-study of the UK Biobank. Associations of body composition measures with each of LVEF and PWASI, after mutual adjustment for one another and potential confounders, were determined using multivariable linear regression.

Results

Among regional body fat measures, higher visceral fat (VAT) was associated with lower LVEF (β = − 0.45; 95% CI − 0.60, − 0.31 per SD) and higher PWASI (β = 0.51; 95% CI 0.38–0.65 per SD). The association between VAT and LVEF was negatively linear but positively linear for PWASI throughout the range of VAT measured. Other regional fat measures and fat-free mass were not significantly associated with either LVEF or PWASI. Central adiposity measures (waist circumference [WC] and waist–hip ratio [WHR]) showed significant inverse association with LVEF (WC: β = − 0.11; 95% CI − 0.21, − 0.01 per SD; WHR β = − 0.25; 95% CI − 0.38, − 0.12 per SD) but positive association with PWASI (WC: β = 0.37; 95% CI 0.28–0.47 per SD; WHR β = 0.39; 95% CI 0.27 − 0.51 per SD) while BMI was not significantly associated with LVEF (β = 0.05; 95% CI − 0.04, 0.14 per SD) but showed weaker positive association with PWASI (β = 0.27; 95% CI 0.18–0.35 per SD).

Conclusions

Excess visceral fat and central adiposity are associated with impaired LV function and increased arterial stiffness which may predispose to heart failure.
Improving compliance with COVID-19 guidance: a workplace field experiment
Authors: Arroyos-Calvera Danae , Drouvelis Michalis , Lohse Johannes , McDonald Rebecca
Published: November 2023

Compliance with hygiene and other safety measures in the workplace was an important component of society's strategy for reducing infections at the onset of the COVID-19 pandemic, in particular before vaccinations were widely available. We report the results of a field trial of well-established behavioural interventions (social norms, pledging and messenger effects) we implemented to improve compliance with such measures in an occupational setting. We use daily reports of own and other's behaviour to assess the effects of these interventions and supplement these subjective (self-reported) measures with objective data on hand sanitiser usage. The behavioural interventions tested have statistically significant but quantitatively moderate effects on subjective compliance measures and minimal effects on hand sanitiser usage. All effects of our interventions are short-term in nature and dissipate shortly after implementation. Our findings thus provide at most weak support for the notion that typical behavioural interventions can help support compliance with infection prevention measures in the workplace.
Voter Preferences for EU Asylum Policies: The Role of Government Cues
Authors: Kriesi Hanspeter , Vrânceanu Alina
Published: November 2023

We study whether and how governments influence public opinion about immigration policies in Europe. At the European level, conflicts about policy are generally territorial in nature – that is, they involve conflicts between member states, which are represented by their governments. Distinguishing between four types of situations, depending on whether the national governments support or oppose EU policy proposals, we formulate and test hypotheses concerning the positions of incumbent and opposition voters/non-voters on four different asylum-policy proposals in 16 European countries. We test both direct effects of incumbent cues on voters' preferences, and moderating effects, where the cueing affects the way in which individual attitudes to immigration and European integration translate into specific preferences for EU asylum and immigration policies. Our results suggest that voters, indeed, follow the cues provided by their governments when forming their preferences on EU policies.
Modelling the replacement of red and processed meat with plant-based alternatives and the estimated effect on insulin sensitivity in a cohort of Australian adults
Authors: Goode James P. , Smith Kylie J. , Breslin Monique , Kilpatrick Michelle , Dwyer Terence , Venn Alison J. , Magnussen Costan G.
Published: November 2023

Dietary guidelines are increasingly promoting mostly plant-based diets, limits on red meat consumption, and plant-based sources of protein for health and environmental reasons. It is unclear how the resulting food substitutions associate with insulin resistance, a risk factor for type 2 diabetes. We modelled the replacement of red and processed meat with plant-based alternatives and the estimated effect on insulin sensitivity. We included 783 participants (55 % female) from the Childhood Determinants of Adult Health study, a population-based cohort of Australians. In adulthood, diet was assessed at three time points using FFQ: 2004–2006, 2009–2011 and 2017–2019. We calculated the average daily intake of each food group in standard serves. Insulin sensitivity was estimated from fasting glucose and insulin concentrations in 2017–2019 (aged 39–49 years) using homoeostasis model assessment. Replacing red meat with a combination of plant-based alternatives was associated with higher insulin sensitivity (β = 10·5 percentage points, 95 % CI (4·1, 17·4)). Adjustment for waist circumference attenuated this association by 61·7 %. Replacing red meat with either legumes, nuts/seeds or wholegrains was likewise associated with higher insulin sensitivity. Point estimates were similar but less precise when replacing processed meat with plant-based alternatives. Our modelling suggests that regularly replacing red meat, and possibly processed meat, with plant-based alternatives may associate with higher insulin sensitivity. Further, abdominal adiposity may be an important mediator in this relationship. Our findings support advice to prioritise plant-based sources of protein at the expense of red meat consumption.
On sin-based responses to divine hiddenness
Authors: Baker-Hytch Max
Published: November 2023

While sin-based responses to divine hiddenness arguments are a road less travelled, they do nonetheless have a number of defenders in the contemporary divine hiddenness literature. I begin this article by exploring the various strategies that have been employed to attempt to motivate such accounts. What none of these strategies seem to take into account, however, is a cluster of facts about the correlation (or lack thereof) between a person's propositional attitudes about God and the degree to which that person displays the relevant moral and intellectual virtues. This article aims to fill this lacuna by mapping out the options available to defenders of sin-based responses in trying to cope with this cluster of facts. I argue that there may be resources available for preserving some aspects of the sin-based approach, but that taking stock of the aforementioned facts will ultimately require the positing of causal factors besides sin in order to generate a sufficient explanation of the phenomenon of non-belief.
Spread-out limit of the critical points for lattice trees and lattice animals in dimensions
Authors: Kawamoto Noe , Sakai Akira
Published: November 2023

A spread-out lattice animal is a finite connected set of edges in $\{\{x,y\}\subset \mathbb{Z}^d\;:\;0\lt \|x-y\|\le L\}$. A lattice tree is a lattice animal with no loops. The best estimate on the critical point $p_{\textrm{c}}$ so far was achieved by Penrose (J. Stat. Phys. 77, 3–15, 1994) : $p_{\textrm{c}}=1/e+O(L^{-2d/7}\log L)$ for both models for all $d\ge 1$. In this paper, we show that $p_{\textrm{c}}=1/e+CL^{-d}+O(L^{-d-1})$ for all $d\gt 8$, where the model-dependent constant $C$ has the random-walk representation
\begin{align*} C_{\textrm{LT}}=\sum _{n=2}^\infty \frac{n+1}{2e}U^{*n}(o),&& C_{\textrm{LA}}=C_{\textrm{LT}}-\frac 1{2e^2}\sum _{n=3}^\infty U^{*n}(o), \end{align*}where $U^{*n}$ is the $n$-fold convolution of the uniform distribution on the $d$-dimensional ball $\{x\in{\mathbb R}^d\;: \|x\|\le 1\}$. The proof is based on a novel use of the lace expansion for the 2-point function and detailed analysis of the 1-point function at a certain value of $p$ that is designed to make the analysis extremely simple.
From flesh to paper: bodily and material transformation in seventeenth-century Copenhagen – a case-study
Authors: Hansen Peter W. , Jakobsen Jesper , Langen Ulrik , Simonsen Rikke
Published: November 2023

This article investigates the transformation of the body of a female child murderer as she passed through specific spatial configurations in the urban setting of the seventeenth-century capital of Denmark–Norway. By using the case of Gertrud Nielsdatter, we explore the significance of public urban spaces in the bodily and material transformation of a woman from a condemned sinner to an object of scientific wonder. This transformation was facilitated by practices in diverse public spaces – controlled or influenced by government, city, church, as well as academic authorities and stakeholders – such as the city court, the place of execution, the university and, not least, the book shops across Europe selling books containing the print representing internal organs of Gertrud Nielsdatter. The case demonstrates how the physical body of an ordinary – yet outlawed – Copenhagener was repeatedly transformed in interaction with public spaces and the material culture of buildings, fixtures and fittings.