bluuebunny/crossref_metadata_2025 huggingface dataset:
Deber de las partes de considerar el uso de la mediación en el proyecto de código procesal civil. Análisis comparado
Authors: Fiegelist Boris
Published: February 2023

El presente trabajo, se concentrará en el estudio del deber de las partes de considerar el uso de la mediación, como de uno de los incentivos establecidos por el proyecto de Código Procesal Civil para promocionar el uso de los mecanismos alternativos. El objetivo específico del presente trabajo será formular una propuesta de mejoras concretas a la regulación del antes mencionado deber de las partes, una vez que se ha iniciado la vía jurisdiccional, en el referido proyecto de Código. Para ello, el estudio se dividirá en tres partes. La primera, se procederá a describir y contextualizar la regulación del mencionado deber en dicho proyecto. En la segunda, se procederá a comparar la antes referida propuesta, con la regulación de esa materia en la Ley de Enjuiciamiento Civil española, la normativa federal de Estados Unidos y las reglas de procedimiento civil de Inglaterra y Gales. Finalmente, en base a los hallazgos del antes señala revisión comparada, se formulará una propuesta de mejoras concretas a la regulación del deber de consideración de la mediación contenido en el proyecto de nuevo Código Procesal Civil chileno.
Comentario a sentencia recaída sobre recurso de casación de 2 de mayo de 2022. Causa rol nº 33.128-2020
Authors: Silva Valentina
Published: February 2023

El presente comentario analiza la especialidad de la Sana Crítica como sistema de valoración de la prueba de la ley n° 18.101 y la elaboración del recurso de casación. Se desarrolla qué es la Sana Crítica y se establece la relación de especialidad entre la ley y el código de procedimiento civil. Luego, se desarrolla la dificultad de fundar el recurso de casación por infracción a las normas de la sana crítica en tanto normas implícitas.
Identidad de género: un derecho implícito cuya deficiente configuración se erige como una barrera de acceso a la justicia. Comentario a la sentencia rol 88713-2021 de la Corte Suprema
Authors: Espinosa Lorena
Published: February 2023

El presente trabajo tiene por objetivo analizar la sentencia de la Corte Suprema, rol 88713-2021, de fecha 18 de abril de 2022. Se trata de un fallo que, conociendo de la apelación de un recurso de protección, tuvo que resolver si el actuar del Hospital de Carabineros de Chile en cuanto a dilatar la ejecución de una operación de reasignación de sexo a una persona mayor de edad, calificaba como una acción arbitraria e ilegal. Se trata de una sentencia relevante no solo porque marca una nueva línea jurisprudencial al reconocer la existencia de un derecho implícito a la identidad de género, sino porque nos permite precisar el concepto de identidad de género y argumentar cómo, una inadecuada comprensión de ella, se erige como una barrera de acceso a la justicia.
A clinical study to evaluate the efficacy of Dahaprashamana Gana in the management of Vasomotor Symptoms in Perimenopause and Menopause
Authors: Aiswarya Venunadh  , Shruti S. Patil
Published: February 2023

Background: Menopause is a transitional phase marking the finale of the reproductive life of a woman. It’s associated with complex physical and psychological changes. The vasomotor symptoms are the hallmark of menopause, affecting 75% of women and among this 25% are severely affected and are the most common and long-lasting symptoms according to many studies. In Ayurvedic literature “Rajonivrutti” has very little references available. The age of Rajonivruthi is said to be around 50 years as per the classics and it is considered as a premonitory sign of Jara in women. The vasomotor symptoms like hot flushes, night sweats, irritability clearly indicate the involvement of dominant Pitta Dosha associated with Vata. Hence a drug that pacifies Pitta along with Vata, without disturbing Kapha will be ideal for treatment. Dahaprashamana Gana explained in Charaka Samhitha Sutrasthana, denotes a group of medicinal plants, which has been indicated as useful in removing Daha which is a direct manifestation of Pitta. Aim: To analyse the effect of Dahaprashamana Churna in the management of vasomotor symptoms in perimenopause and menopause. Method: A simple randomized open label controlled clinical study thirty subjects fulfilling the diagnostic criteria of Vasomotor symptoms were selected and randomly categorized to Group A and Group B by using lottery method. Result: Dahaprashamana Churna found to be effective in all subjective and objective parameters. Conclusion: Dahaprashamana Churna is more effective than Vitamin E in the management of Vasomotor symptoms in Perimenopause and Menopause
To evaluate the efficacy of Ashwattha Churna with and without Virechana Karma in Ksheena Shukra (oligo-zoospermia) - A Comparative Study
Authors: Lokesh  , Pankaj Kumar Katara
Published: February 2023

In present scenario cases of infertility arise abundantly which is a serious problem among the present generation as it affects the person mentally hence can deteriorate life. There are various etiological factors related to male infertility. In Ayurveda the quality of Shukra is mentioned by various Acharya to produce a healthy progeny. But Shukra Dushti can lead to differently abled or no progeny. There are various types of Shukra Dushti mentioned by Acharya Sushrut, Ksheena -Shukra is one of them. Aim: To compare the efficacy of Virechana Karma followed by Ashwattha Churna and Ashwattha Churna alone in Ksheena Shukra (oligozoospermia). Objective: To assess the efficacy of Virechana Karma followed by Ashwattha Churna in Ksheena Shukra and to assess the efficacy of Ashwattha Churna alone in Ksheena Shukra and to detect increase in sperm count. Methods: It is open label, randomized, interventional and comparative study. Group A - In this group Virechana Karma followed by Ashwattha Churna was given. Group B - In this group Ashwattha Churna was given. Result: Group A (Virechana Karma followed by Ashwattha Churna) there was an increase of 55% in sperm count, increase of 11.6% in sperm motility, relief in Maithuna Ashakti is 50%, relief in Medra Vrishna Vedana is 32%, and relief in Chiraat Prashek is 32%. Conclusion: Both group shows statistically significant results in parameters i.e., Maithuna Ashakti, Medra Vrishna Vedana, Chiraat Prashek, sperm count, motility.
Effect of Siddharthaka Agada Arka Pratimarsha Nasya in Kaphaja Unmada (Depressive Disorders)
Authors: Anirudh Sehra  , Suhas Kumar Shetty  , Savitha HP
Published: February 2023

In Ayurveda, the term ‘Unmada’ encompasses a wide spectrum of mental disorders. Unmada means "a state of disrupted mental functioning" in etymological terms. The aggravation of Kapha Dosha causes Kaphaja Unmada, which is one of the five forms of Unmada. The symptomatology and description of Kaphaja Unmada can be found in all major Ayurvedic texts. "Kaphaja Unmada" has been linked to "depressive disorder"/"depression"/"major depressive disorder" in previous studies. In this regard, it was planned to do a clinical study on the effectiveness of Siddharthaka Agada Arka Pratimarsha Nasya in Kaphaja Unmada (depressive disorders). Resulting in a statistically significant improvement in the primary and secondary outcome measures of Kaphaja Unmada (Depressive disorders). Thus, concluding Siddharthaka Agada in the form of Arka, administered as Pratimarsha Nasya for 30 days, with a dosage of two drops per nostril, twice a day, before food, is effective in Kaphaja Unmada (Depressive Disorders).
A comparative pharmaceutical and analytical study of Shirisharishta prepared by Twak, Sara and Kastha from Shirisha
Authors: Rajdeep Pain  , Vidyarani M
Published: February 2023

Shirisha (Albizzia lebbeck Benth.) is well known classical drug used for the treatment of various types of diseases such as Shwasa, Kasa, Shosh etc. In this study 3 different sample of Shirisharista prepared from 3 different main ingredient Twak Sara and Kastha along with herbs like Pippali Priyangu etc. Shirisharishta is one such formulation mentioned under Visha Chikitsa, which is in use as a mode of Shaman Chikitsa. The reference of this Yoga is adopted from Bhaishajya Ratnavali. To formulate Shirisharista from Twak, Sara and Kastha from Shirisha and evaluate their pharmaceutical and analytical characteristics. Shirisharishta was prepared from Twak Sara and Kastha of A. lebbeck. Organoleptic characterization pH, specific gravity, total solid content, alcohol content and TLC profile of the prepared 3 samples were determined. Heartwood is the best part of use of A. lebbeck for preparation of Shirisharishta.
Effect of Ayurvedic Treatment Modalities on Recurrent Pregnancy Loss
Authors: Asha Sreedhar  , S. Shahinamole  , Asha S T  , Shiny S Raj  , Anila M  , Rajini P
Published: February 2023

Recurrent pregnancy Loss is defined as the sequence of 2 or more spontaneous abortions as documented by either sonography or on histopathology before 20 weeks. It is a relatively common event, occurring in 15%-25% of pregnancies, and increasing in prevalence with maternal age. The causes of recurrent abortion are complex & obscure. More than one factor may operate in a case. Identification and treatment of problems significantly increases the successful outcome in most cases. Recurrent pregnancy loss can be correlated with Puthraghni Yonivyapath and Garbhasravivandhya explained in Ayurvedic classics. Puthraghni is a clinical entity characterised by repeated pregnancy loss due to excessive intake of Rooksha Ahara and Vihara which results in repeated pregnancy losses. Ayurveda advises to do Shodhana Karma or purificatory therapies ending with Uttara Vasthi in recurrent losses. The study design was Prospective single arm interventional study conducted in the OPD and IPD of Govt. Ayurveda college hospital for Women and Children, Poojapura, Thiruvananthapuram with the study population of females of age group 20-38, diagnosed with RPL. IP management was done for 1 month followed by internal administration of Phala Sarpis as Vicharana Snehapana 10ml twice daily morning and evening ½ hour before food and Vilwadi Gulika 1 tab twice daily after food was also given for 2 months. After 15 months after the follow up period, Statistical analysis was done and Percentage of live births was assessed. Even though percentage of live births is 42.3, the success rate can be considered as 46.15% as the 1 patient to be delivered has completed 34 weeks of gestation and successfully continuing the pregnancy.
An open label single arm clinical study on the effectiveness of Akarakarabha Vati in the management of Klaibya (Erectile Dysfunction)
Authors: Sunil Sabasannavar Jinnappa  , Girish KJ  , Nehaa Srinivasan  , Vibhu Sudhakar Powar
Published: February 2023

Background: Klaibya (Erectile Dysfunction) is one of the common sexual disorders that affects physical and psychosocial health and may significantly impact the quality of life of sufferers and their partners. Sexual health and function are important determinants of quality of life. Although lifestyle modifications and psychotherapy are considered as the first-line of treatment in Erectile Dysfunction (ED), men presenting with such complaints expect the Ayurveda physician to help them with measures and medication that can have an improved result. Akarakarabaha is a potent drug mentioned in classical textbooks which is having the Shukrasthambaka (inhibition if delayed ejaculation), Balya (strength promoting activity), Vrishya (aphrodisiac), Vajikara properties and it’s having pharmacological activities like antioxidants, aphrodisiac, immunomodulatory effect, antidepressant, anti-diabetic, and effect on testosterone. Methods: Among 11 subjects, 10 of them completed the course of treatment. They were administered with Akarakarabha Vati 500 mg twice a day with milk as Anupana after food for 30 days and 15 days after cessation of medicine. For statistical analysis subjective parameters were assessed with Cochran Q test followed by McNemar test also Friedman's test followed by Wilcoxon sign rank test, and objective parameters were assessed by repeated measure ANOVA followed by Paired t-test. Results: There was statistically significant improvement in the Klaibya Samanya Lakshana and IIEF (International Index of Erectile function) score. Conclusion: Akarakarabaha Vati is effective in the management of Klaibya (Erectile Dysfunction).
A clinical study on the combined effectiveness of Pathyadi Churna and Kshara Basti in Amavata (Rheumatoid Arthritis)
Authors: Nehaa Srinivasan  , Girish KJ  , Sunil Sabasannavar Jinnappa  , Vibhu Sudhakar Powar
Published: February 2023

Background & Objectives: Amavata (Rheumatoid Arthritis-RA) is a disease caused due to deranged Agni leading to Ama formation. The Lakshanas are very similar to Rheumatoid Arthritis (RA), an autoimmune disorder which causes chronic inflammation and symmetric, peripheral polyarthritis. Pathyadi Churna and Kshara Basti are mentioned in the classics for the treatment of Amavata. Methods: Among 33 registered patients, 30 of them completed the course of treatment. They were administered with Pathyadi Churna 1 Karsha (12g) thrice daily before food with Ushnodaka as Anupana (adjuvant) for a period of 15 days along with Kshara Basti in a modified Yoga Basti format for the first 5 days.  Friedman's test with Wilcoxon sign rank test as post hoc was used to analyze the significance of change in Ordinal data and Repeated measure ANOVA after applying Bonferroni correction and Paired t test as post hoc was used to analyze the significance of change in Scale data. Results: There was statistically significant improvement in the primary and secondary outcome measures of Amavata. Interpretation and Conclusion: Pathyadi Churna and Kshara Basti are effective in the management of Amavata.
A comparative clinical trial to evaluate the efficacy of Rasnadi Churna Basti with Ardha Matrika Basti in the management of Amavata vis-à-vis Rheumatoid Arthritis
Authors: Pratibha M Kodabal  , V. Rajendra
Published: February 2023

Background: Amavata is one among the pain predominant diseases. The disease Amavata has similarity with Rheumatoid arthritis in clinical presentation. In the present study an attempt was made to compare the efficacy of Rasnadi Churna Basti with Ardha Matrika Basti in the management of Amavata. Objective of the study: To compare the efficacy of Rasnadi Churna Basti with Ardha Matrika Basti in the management of Amavata vis-à-vis Rheumatoid Arthritis. Materials and Methods: A double arm open labeled clinical study with pre-post-test design was carried out at Government Ayurveda Medical College and Hospital, Mysuru. Data was collected as per the proforma prepared for the purpose of the study. Study was completed in 42 subjects with 21 subjects in both the groups. For Group A Rasnadi Churna Basti and for Group B Ardha Matrika Basti in Yoga Basti pattern for 8 consecutive days was administered. The data was analyzed using SPSS descriptive and inferential statistics. Results: The statistical values showed highly significant results in Sandhi Shoola, Sandhi Shotha, Sandhi Stabhdata, functional grading, ESR, and DAS parameters. In CRP parameter, result was statistically significant in Group-A and non significant in Group-B. Hb% parameter showed statistically non-significant results in both the groups. On overall assessment, there was no statistically significant difference in the results between the groups except CRP and DAS parameters. Conclusion: Both Rasnadi Churna Basti and Ardha Matrika Basti are useful in reducing the signs and symptoms of Amavata vis-à-vis Rheumatoid Arthritis.
A clinical study in the management of Garbhini Mutrakricchra with Shatavari Ksheerapaka w.s.r. to UTI in Pregnancy
Authors: Deepshikha Sharma  , Savita S. Patil
Published: February 2023

Background: Pregnancy is the state of carrying a developing embryo or fetus within the female body. Profound biochemical, anatomical and physiological changes occur during the course of pregnancy. Urinary tract infections are the second most common infections worldwide. Pregnant women have 4 times higher rate of developing UTI as compared to non-pregnant women.  Pregnant women develop ureteral dilation resulting in increased urinary stasis and ureterovesical reflux due to increased progesterone level and the pressure of gravid uterus on the bladder. The classical Lakshanas of Mutrakricchra like frequent micturition, difficulty during micturition, burning sensation during micturition are similar to the signs and symptoms of Urinary tract infection. Shatavari Ksheerapaka has been mentioned in Sahasrayogam for the management of Mutrakricchra.  Shatavari is Sheeta in Virya, acts as a diuretic and helps in the reduction of Mutrakricchra symptoms. According to Bhavprakash Nighantu, Sita is Ruchikara and Ksheera is Rasayana. Aim: To evaluate the efficacy of Shatavari Ksheerapaka in Garbhini Mutrakricchra w.s.r UTI in Pregnancy. Method: It is a controlled clinical study of two groups consisting 15 patient each in control and trial group. Conclusion: Shatavari Ksheerapaka and Trinapanchmoola Ksheerapaka both are equally effective in treating the Garbhini Mutrakricchra w.s.r. UTI in Pregnancy.
A Survey Study on Leech Storage Practices in Ayurveda Hospitals
Authors: Sudeepa  , Gururaj D.  , Sneha A
Published: February 2023

Leech therapy is one of the popular treatment method adopted in Ayurveda hospitals. We have conducted a survey study to evaluate the method of collection; storage and maintenance of leeches. Data regarding the leech storage were collected from 31 Ayurveda hospitals, on the basis of a standardized questionnaire. All the responding hospitals practiced leech therapy, mostly with a storage setup in the minor OT. 68% procured leeches during rainy season from the leech suppliers. 42% responders used tap water and plastic jars for storage. 94% of Ayurveda hospitals did not subject the water used for storage of medicinal leeches for physiochemical and microbial parameters periodically. There is a need for breeding centers in order to supply of medicinal leeches throughout the year. There is a need for establishing national guidelines for good storage and maintenance of medicinal leeches in India.
Relation of Prakriti and Skin Color - An Observational Study
Authors: Rajeshwari Vantagodi
Published: February 2023

Prakriti is one of the most important concepts in Ayurveda which is of 7 types i.e., Vataja, Pittaja, Kaphaja, three Dwandaja and one Sannipataja. Prakriti is first Pariksha mentioned in Charaka Samhita among Dashavidhapariksha. Assessment of Prakriti is done based on Anatomical, Physiological, Psychological, and Behavioural factors. Twak Shareera is one of the important anatomical features used in the assessment of Prakriti. In this article, an attempt is made to understand the color of Twak and its relationship with Prakriti. An observational study of 150 healthy subjects was conducted to assess the Prakriti of individual and its relationship with Twak Shareera. We used Von Luschan's chromatic scale (VLS) and The Fitzpatrick scale for classifying skin color. The more the VLS Score, the darker the skin color is.  The present study showed that VLS Score increases wherever there is involvement of Vata and Fitzpatrick scale showed that Vataja Prakriti are more of Dark brown in color compared to Pitta. Thus, it can be said that skin color is Genetic in nature and correlated with our theory of Prakriti.
Pharmaceutico Analytical Study of Jatipatradi Churna
Authors: Veena Nandennavar  , Pavan Kulkarni
Published: February 2023

Oral thrush is an opportunistic infection of the oral cavity. It is common and underdiagnosed among the elders. It is also called as oral candidiasis and is a condition in which the fungus Candida albicans accumulates on the lining of mouth. Candida is a normal organism in our mouth, but sometimes it can overgrow and cause symptoms. The incidence of C Albicans is 45% in neonates, 45-65% in healthy children, 30-45% of healthy adults, 50-65% of people who wear removable dentures, 90% of patients with acute leukaemia and undergoing chemotherapy and 95% of HIV infected patients. Oral thrush causes creamy white lesions, usually on the tongue or inner cheeks. Sometimes oral thrush may spread to the roof of mouth, gums or tonsils, or the back of throat. Jaatipatradi Choorna is one of the formulations explained in Yogaratnakara in Dantaroga Chikitsadhaya containing the ingredients like Jaatipatra, Punarnava, Gajapippali, Kushta, Vacha, Shunti, Ajamoda, Haritaki and Tila which are having Krimighna and Khandughna property. Hence, this present study has been undertaken to prepare Jaatipatradi Choorna and subjecting it to standard analytical parameters of Churna Kalpana.
A clinical study on combined effect of Padabhyanga and Pranayama in Nidranasha (Primary Insomnia) - Research Article
Authors: Akshay B Hiremath  , Gurubasavaraj Yalagachin  , Resmi K K  , Uday T S  , Chaithra H N  , Ashitha N K
Published: February 2023

Sleep is one of the most significant human behaviour, occupying roughly one third of human life. It is the state of mind during which it blocks all the perception from the external world. Qualitative sleep is the essential component of good health. Disturbed sleep leads to discomfort and diseases, can be identified as longer time taken to fall asleep, more periods of wakefulness during the night, and time spent lying awake before rising in the morning. The reported prevalence of insomnia is 33% in the general population globally, and 16% in India and 18.6% in South India. Padabhyanga as a part of Dinacharya is said to induce sound sleep and Pranayama not only enhances Pranashakti but also calms down the stress on body and mind. Hence, in the current study, the combined effect of Padabhyanga and Pranayama practice among elderly population is attempted as remedial measures.
Post Marketing Efficacy and Safety Study of BOHECO Peace (Full Spectrum Hemp Leaf Extract Based Ayurvedic Proprietary Medicine) for the Management of Pain
Authors: Shameen Salim  , Neeraj Kumar Patel  , Jahan Peston Jamas
Published: February 2023

Introduction: The use of Cannabis leaf-based medicines is being developed at an exponential rate with more and more studies and research carried out to assess the efficacy of the drug in various illnesses including management of pain. Materials and Methods: 50 patients who had been on the full spectrum cannabis leaf based ayurvedic proprietary medicine manufactured by Bombay Hemp Company, Mumbai, India for pain were selected for the study. Separate structured multiple-choice questionnaires were used for the assessment of safety and efficacy of BOHECO’s PEACE manufactured by BOHECO. Results: In Overall effect of management of Pain, out of 50 participants, 47 responses were received in which, 3 patients (6.4%) reported complete remission of the pain, 28 patients (59.5%) reported marked improvement, 15 patients (31.9%) were getting moderate Improvement and one patient (2.1%) reported mild improvement. Out of 15 patients who reported adverse events, most reported AEs were dry mouth in 12 patients which is a common response of the body to Cannabis leaf-based medicine, mild euphoria in 3 patients, somnolence in 2 patients, sedation in 2 patients and anxiety in 1 patient. The mild AEs reported were self-limiting without any medical intervention. Conclusion: Full Spectrum Hemp leaf extract based Ayurvedic proprietary medicine sold under the brand name BOHECO PEACE used for the management of pain has been observed to be effective and safe for long term use. It is observed to have reduced chronic pain with no serious adverse reactions at prescribed doses.
A clinical study to evaluate the effect of Guduchyadi Ksheerabasti in Hyperuricemia
Authors: Kalyani Sarvade  , Niranjan Rao  , Sandesh Shetty
Published: February 2023

Background: Hyperuricemia affects approximately 5.9% of men and 2.0% of women and around 12% of overall population. Vatarakta is correlated with hyperuricemia is a acute/chronic inflammatory condition of joint takes place predominantly where serum uric acid is raised beyond 6.8 mg/dL. Aims and Objectives: Assessment of Guduchyadi Ksheera Basti in the management of Hyperuricemia. Methodology: The 23 patients of either sex belonging to age between 20-70 years having signs and symptoms of Hyperuricemia and confirmatory haematological investigations, were selected and after local massage and fomentation, were administered Ksheera Basti through anal route for a period of 8 days (Kala Basti Schedule) Niruha and Anuvasana given on the same day. Results were statistically analysed by using paired ‘t’ test and Wilcoxon signed rank test. Observations and Results: Ksheera Basti provided statistically highly Significant effect (p<0.001) in improving in almost all the cardinal symptoms of Hyperuricemia. It also provided statistically highly significant results in improving all the given parameter in Visual Analogue Scale (VAS), Numerical rating scale (NRS), Verbal Rating Scale (VRS), status of serum uric acid, Bodily pain assessment, due to nourishing, rejuvenating, anti-inflammatory, immunomodulatory and analgesic properties of ingredients. Conclusion: Guduchyadi Ksheera Basti yields good clinical improvement in pacifying Vatadhika, Pittadhika Vatarakta.
A clinical study to effect of Dhanyamla Parisheka in Rheumatoid Arthritis
Authors: Athreya Sharma M  , Niranjan Rao  , Sandesh Kumar Shetty
Published: February 2023

Background: Bahirparimarjana Chikitsa is one of two modes of treatment explained in Ayurvedic medical science. Doshas move from internal Koshta to Shaakha during disease pathology or Roga Samprapti. Swedana is considered one such treatment protocol to bring Doshas from Shaakha to Koshta. Parisheka is a method of Swedana by pouring medicated water or oil over the body. Dhanyamla Parisheka is a Rooksha inducing Parisheka Sweda. Amavata is a disease with predominant Kapha and Vata Dosha. Its Vyaktha Sthana is predominantly Sandhi with severe pain and swelling. Treatment of Amavata includes Rooksha Swedana. Symptoms of rheumatoid arthritis largely correlate with the symptoms present in Amavata. Global prevalence rates of Rheumatoid Arthritis with genetic associations in India is 0.1-0.4%. Methods: In this study, 50 patients diagnosed with Rheumatoid arthritis were selected and subjected for Dhanyamla Parisheka. This study involves estimation of Rheumatoid factor, C-reactive protein and Anti streptolysin O titre levels before treatment and after follow-up period and evaluation of pain, swelling, tenderness and range of movement of joints involved in the subjects before and after Dhanyamla Parisheka for 7 days. The results are suggestive of effect of the Dhanyamla Parisheka. Results: There was statistically significant reduction in Rheumatoid arthritis score in the subjects. Interpretation: Dhanyamla Parisheka is an effective Bahirparimarjana Chikithsa in subjects with rheumatoid arthritis.
Clinical review on comparative study of two different formulations Amritadi Kwatha and Kandughna Mahakashaya Ghan Vati on the basis of clinical efficacy in patients of Udarda
Authors: Puneet Sharma  , Satish Gandharve  , Rajesh Sood
Published: February 2023

Present study deals with study and comparison of two ayurveda formulations in the patients of Udarda. Amritadi Kwath and Kandughna Mahakashaya Ghan Vati were used in separate groups of patients and their effect was compared. Kandughna Mahakashaya Ghan Vati was found to be more effective in the patients of Udarda.
Development and Physico-Chemical Analysis of Varnya Lepa Sunscreen Lotion (In-Vitro)
Authors: Shikha  , Prashant G. Jadar  , Uday B. Bolmal
Published: February 2023

Background: Direct exposure to Solar radiation causes many harmful effects on the skin like suntan, sunburn, hyperpigmentation and skin ageing etc. To overcome these types of problems sunscreen applications can be helpful. In Ayurveda, authors explained Varnya Lepa drugs like Raktachandana (Pterocarpus santalinus Linn.), Manjistha (Rubia cordifolia Linn), Lodhra (Symplocos racemosa Roxb), Kustha (Saussurea lappa), Priyangu (Callicarpa macrophylla), Vatankura (Ficus benghalensis) and Masura (Lens culinaria Medic) have a high potential due to their antioxidant activity, vitamin, photoprotective, flavonoids and phenolic acid in the safety of the skin from UV rays and blocks each UVA and UVB. This formulation is mentioned for external application in the form of Lepa but due to problems like stains after applications, impediment in utilization, protection trouble, non-accessibility of crisp medication all the season. If Lepa contains herbal drugs it should be used within 24 hours, otherwise, the drugs get decomposed and the application may harm the skin. Lotion is viscous semisolid preparation. They may be oil-in-water or water-in-oil type, easy to apply in unbroken skin without friction. Lotions contain water-soluble bases and hence are more convenient to use. Aim: The present study aim was to develop Varnya Lepa sunscreen lotion and Assessment of Sun Protection Factor (SPF) by In-vitro method. Material and Methods: A lotion base of Four trials was done, in this trial fourth was passed all parameters and the final development of sunscreen lotion was prepared. The quantity of extract used in sunscreen lotion was selected after assessment of the absorbance factor in UV-spectrophotometry and calculated sun protection factor. Results: The Sun protection factor was obtained 29 and shown under broad-spectrum sunscreen. Conclusion: Varnya Lepa sunscreen lotion was successfully developed. Hence, can be used as sunscreen lotion.
Understanding the etiopathogenesis of Uttana Vatarakta (peripheral vascular disease) - An Observational Study
Authors: Namratha MV  , Prashanth Jain  , Geetha B Markande
Published: February 2023

Advanced life style and changing food habits affects the activities of individual which leads to many diseases and Peripheral Vascular Diseases are one among them. They are characterized by reduction of blood flow and oxygen supply through peripheral vascular vessels. This can happen in arteries or veins. The incidence of Varicose vein is more common with age and high prevalence is after 30 years of life. PAD occurs in patients over 40 years old; the highest incidence occurs in the sixth and seventh decades of life and it affects 10-15% of the general population. The symptoms of Uttana Vatarakta owing to the Margavarana pathology simulate with the symptoms of Peripheral vascular diseases and some of the etiological factors of Uttana Vatarakta in the writing are specific in inclining Peripheral Vascular Diseases. Ayurveda emphasise the importance of study on etiopathogenesis of disease before the planning of treatment protocol. In this study an effort is done to identify the Nidanas and pattern of Samprapti in relation with Peripheral vascular diseases for the better understanding of different clinical presentations of Uttana Vatarakta.
Understanding the etiopathogenesis of Katigraha - An Observational Study
Authors: Kavya Krishnan C  , Geetha B Markande  , Prashanth Jain
Published: February 2023

Katigraha is one among the Vataja Nanatmaja Vyadhi which simulates with the signs and symptoms of Low Back pain. It continues to be the most common health concern for which patients seek primary care therapy. Our Acharyas explains Katigraha as a Lakshana in various Vatavyadhi and in other diseases. Here, Katigraha indicates a disease condition of the back associated with pain and stiff movements. As Gada Nigraha clearly states pain is produced due to stiffness produced by Saama or Niraama Vayu movement in to Kati hence this suggests of presence of Dhatu Kshayatmaka and Marga Avarodhaka type of Samprapti. Hence in this context Katigraha denotes a group of symptoms characterized by the restriction of movements of Kati region in which pain would be a main feature as Graha alternatively means pain as restriction is said to produce pain in the particular region. The backache or lumbago is one of conditions which results from violation of bio mechanics of spine as it results when the physical and mental strain and faulty postures alter anthropometrical precision. The 70-80% of world population suffers from backache at some point of their life. As the back pain is very subjective in nature, there are very few objectives finding in history, clinical examination and even on extensive radiological or laboratory investigation.
A randomized, controlled clinical study to evaluate the role of Sarjarasa Apamarga Ksharasutra in the management of Bhagandara w.s.r to fistula-in-ano
Authors: Anagha TS  , KM Sweta  , Dhyan Surendranath
Published: February 2023

Fistula-in-ano is one of the most common ailments pertaining to ano-rectal region, is prevalent all over the world and its occurance is 8.6 cases per 100,000 population.[1] The main cause known for fistula-in-ano is crypto glandular infection of anal crypts. In Ayurveda, according to similar clinical features the disease Bhagandara can be correlated with fistula in ano. Presently Ksharasutra therapy is found most approaching and attractive treatment modality among para-surgical procedures for fistula in ano. Guggulu Apamarga Ksharasutra which is widely used, having good binding nature and anti-inflammatory effect, But the main complaints reported by the patients are pain and discomfort during and after Ksharasutra procedure. So, instead of Guggulu, Sarjarasa was taken which is having binding property, Vedanasthapaka, Vrana Ropana and Vrana Shodhana Guna, for the Ksharasutra preparation.[2] A total of 30 subjects were taken, Trial group treated with Sarjarasa Apamarga Ksharasutra and control group treated with Guggulu Apamarga Ksharasutra. The study shows Sarjarasa Apamarga Ksharasutra had high efficacy in subjective parameters like pain and burning sensation compared to Guggulu Apamarga Ksharasutra. There were no complications like necrosis, stenosis, anal incontinence after application of Sarjarasa Apamarga Ksharasutra.
A randomised controlled clinical study to evaluate the role of Nirvapana Upakrama with Durva ointment in the management of Pittaja Dushta Vrana with special reference to fissure-in-ano
Authors: Parvathy Gopan  , Padma  , KM Sweta  , Dhyan Surendranath
Published: February 2023

Introduction: Fissure-in-ano is an ulcer in the longitudinal axis of lower anal canal. It is having prevalence of about 17.91%. By seeing the signs and symptoms we can consider it as one among the six varieties of Dushta Vrana i.e., Pittaja Dustavrana. Due to busy life schedules people don’t prefer hospitalization and other operative procedures. So, there is a need to find out a new and simpler medicament which enables easy and better storage, preservation and mode of application. Here an attempt was made to study the effect of Nirvapana Upakrama in the management of fissure in ano is taken. This Upakrama is used for the treatment of Vrana accompanied with Daha, Paka, Jwara and having Pitta Kopa and Raktena Abhibhuta. Since fissure is having the similar symptoms this treatment can be adopted for the management of the same. Methodology: A randomized controlled clinical study was conducted over 30 subjects in two groups.  Fifteen subjects were advised to apply Diltiazem gel and 15 subjects were advised to apply Durva ointment twice daily for a period of 14 days. Results: Rapid reduction in pain, burning sensation and length of ulcer was observed in the subjects who were given Durva ointment. Discussion: Durva ointment having Madura Rasa, Snigdha Guna and Sheeta Virya does Vatapitta Shamana and pacifies vitiated Rakta. Kashaya rasa of Durva does Vrana Ropana and Rakta Sthambana which amplifies in ulcer healing and relaxation of the sphincter.
Clinical study on the combined effectiveness of Mashasaptaka Kwatha and Marsha Nasya with Mashasaptaka Taila in Pakshaghata (cerebrovascular accident-infarct)
Authors: Nidhi Gusain  , Totad Muttappa  , Vasantha B  , Yadu Gopan
Published: February 2023

Background: Pakshaghata is one among Vataja Nanatmaja Vyadhis which are considered as Mahavyadhis. Pakshaghata can be correlated with Hemiplegia, the commonest pathology of which is cerebrovascular accident (stroke). Stroke is defined as sudden onset of neurologic deficit from vascular mechanism. 85% of all strokes are ischemic and 15% are hemorrhagic. Aims And Objectives: To evaluate the combined effectiveness of Mashasaptaka Kwatha and Marsha Nasya with Mashasaptaka Taila in the management of Pakshaghata (Cerebrovascular Accident-infarct). Methods: Thirty diagnosed subjects of Pakshaghata (CVA due to infarct) were administered with Mashasaptaka Kwatha and Marsha Nasya with Mashasaptaka Taila for 7 days. The data of patients was recorded before and after treatment using an elaborate proforma. Assessment was done based on the primary and secondary outcome measures. For statistical analysis, Wilcoxon Signed Rank test, McNemar tests were used. Results: In this study it was found that there was statistically significant relief in the symptoms of Pakshaghata (Cerbrovascular accident-infarct). Conclusion: Relief in the symptoms was achieved by the drugs having properties such as Vatakaphahara, Anulomana, Brimhana, Srotoshodhana etc. Hence, Mashasaptaka Kwatha and Marsha Nasya with Mashasaptaka Taila for 7 days is effective in the management of Pakshaghata (Cerebrovascular accident-infarct).
Pharmaceutico-Analytical Study of Agnikumara Rasa - A Kupipakwa Kalpana
Authors: Jayadevan A  , Ravi R Chavan
Published: February 2023

Agnikumara Rasa is a Sagandha, Sagni, Kantastha Bahirdhuma Kupipakwa Rasayana mentioned in Rasakamadhenu under Sangrahani Chikitsa Adhikara. It is prepared under Kramagni Tapa for 18 hours as per classics. The core ingredients are Shuddha Parada, Shuddha Gandhaka, Shuddha Vatsanabha and Hamsapadi Swarasa. It is indicated in conditions like Sannipata Kasa, Shwasa, Kshaya, Panduroga and Mandagni. Even though a total of 50 formulations have been explained in classics under the name of Agnikumara Rasa, no research work has been done till date on this particular yoga explained in Rasakamadhenu.
Acute and Subacute Toxicity Study of Lehana Yogas in Wistar Albino Rats
Authors: Lara Dias  , Sharaschandra R  , Nagartna SJ  , Sudhakar Bhat
Published: February 2023

Lehana Yogas is an Ayurvedic preparation which are known to enhance growth and development by providing sufficient nutrition and promoting health with improving intellect and speech and administered frequently with ghee and honey to children’s as immune boosters. In this study we assessed the safety parameters of the Lehana Yogas mentioned and its effect on acute and subacute administration in Wistar albino rats. The Wistar strain albino rats were divided into group of five, vehicle group of Ghrita-Madhu, Ghrita-Madhu with Suvarna Bhasma, Ghrita-Madhu -Suvarna Bhasma with Vacha Churna, Ghrita-Madhu -Suvarna Bhasma with Amalaki Churna, respectively. The duration of administration was for 28 days. During the course of study, no mortality and no significant behavioral changes were noticed in any group studied. No major alterations were observed in hematology and serum biochemistry reports. Histopathology of vital organs also shown no toxic effects. Materials and Methods: Thirty albino rats of either sex were selected and assigned to 5 groups of 6 each. Drugs will be administered for the duration of 28 days and will be assessed for toxicity profile at the end of the study. Result: Animals who were administered daily with Lehana Yogas for longer duration did not show any mortality. Hence, it indicates safer use of drugs in terms acute and subacute level of administration. Discussion: It is concluded that the administration of Lehana Yogas is safe and non-toxic at the tested dose levels.
A randomized comparative clinical study to evaluate the effect of Ghanavyoshadi Khanda over Vidarikandadi Khanda in Karshya w.s.r. to Underweight Children
Authors: Aparna KP  , Prathviraj Puranik  , Nagaratna SJ  , Sandesh Shetty
Published: February 2023

Background: Undernutrition is one of the major causes of increased morbidity & mortality among children. One of the most emerging issues in the present scenario is having long-term effects on physical & cognitive development. Underweight is one of the cardinal determinants of under nutrition.  According to a 2019 report, India is ranked 102 out of 119 countries. As per NFHS 4 in India shows 35.7% under 5 children were underweight, 38.4% were stunted & 21% were wasted. Karshya is an Apatarpana Janya Vyadhi.  The trial was proposed to study the comparative effect of Ghanavyoshadi Khanda & Vidaryadi Khanda by using specific parameters for Karshya w.s.r. to underweight. Objective: To evaluate the comparative effect of Ghanavyoshadi Khanda over Vidarikandadi Khanda in the management of Karshya. Materials & Methods: Children of age group 2-5 years were selected from Kaumarabhritya OPD of SDM College of Ayurveda & Hospital, Udupi, also from nearby Anganwadi’s & preschool of Udupi. Selected subjects were randomly allocated into 2 groups of 15 patients each. Group A will be administered with Ghanavyoshadi Khanda along with Sukoshna Ksheera as Anupana twice daily before food and group B with Vidarikandadi Khanda along with Sukoshna Ksheera as Anupana twice daily after food for 1 month. Results: Children showed improvements in all aspects of Karshya w.s.r. to underweight like weight, height, MUAC, & BMI. Both the groups showed highly significant improvement in Kshut, Abyavarana Sakti & significant changes in Badhavitt. Insignificant changes in Alpapranaschakriya, Pipasa & Nidra. Conclusion: It was concluded clinically the consumption of Ghanavyoshadi Khanda & Vidaryadi Khanda along with Sukoshna Ksheera are equally effective in the management of Karshya w.s.r. to underweight in children.
Etiopathological and diagnostic study of Margavaranajanya Hridroga w.s.r. to Coronary Artery Disease - An Observational Study
Authors: Abhishta Jain  , Prashanth Jain  , Geetha B. Markande
Published: February 2023

The incidence of cardiac diseases is increasing at an alarming rate in our society due to sedentary lifestyle as an impact of western culture. In India, many studies have reported increasing coronary artery disease incidence over 60 years. One in 4 deaths in India are due to coronary artery disease. So thorough understanding of pathogenesis of this disease is very important. Ayurveda literature elaborates multiple maladies related to heart under Hridroga. Margavarana is a unique pathology explained in our classics. Various dietary, behavioural, psychological factors contribute to morbid accumulation of Kapha and Medas leading to Shonita Abhishyandana. Further morbid state of Shonita Abhishyandana by Upalepa of Dhamani culminates in development of Dhamani Prathicchaya. Eventually due to Siraaja Granthi Dhamani Prathichhaya ends up in Margavarna and is the leading pathology of Hridroga. In the realm of conventional medicine, it is said that sedentary life style is the major cause of morbid accumulation of fat in the body leading to metabolic syndrome. It is characterised by dyslipidemia which in turn leading to atherosclerosis. Atherosclerosis predisposes the thromboembolism and complete obliteration of blood circulation within the vessel. Hence, in the present study an endeavour is made to corelate the concept of Coronary artery disease and its ill effects with the classical reference regarding the concept of Margavarana pathology occurring in the Hridaya causing Margavaranajanya Hridroga and also its diagnosis through the modern tools.
An open label, single arm prospective clinical study on the effectiveness of Pugaarimeda Kashaya in Madhumeha (Diabetes Mellitus Type 2)
Authors: Pavithra P  , Vasantha B  , Totad Muttappa
Published: February 2023

Background: Diabetes mellitus (DM) is one of the most common non-communicable diseases globally. It is characterized by multiple metabolic disorders that results in hyperglycemia. Diabetes mellitus type-2 (DM2) is the most common type accounting almost 90% of cases of DM. Madhumeha on the basis of similar etiology, signs and symptoms can be co-related with Diabetes mellitus type-2. It is also described by the term Kshoudrameha or Ojomeha. Pugaarimeda Kashaya with Madhu as Anupana is mentioned in Brihat Nighantu Ratnakara in the management of Madhumeha. Objective: To clinically evaluate the effectiveness of Pugaarimeda Kashaya in Madhumeha (Diabetes mellitus type-2). Materials and Methods: Among 31 registered subjects, 28 of them completed the course of treatment. They were administered with Pugaarimeda Kashaya orally 100ml per day (50ml twice daily before food) with Anupana of Madhu 5ml for a period of 30 days. Blood and urine glucose test was done on 1st, 31st day of study initiation. For Statistical analysis subjective parameters were assessed by Cochran’s Q test followed by McNemar test and objective parameters were assessed by Paired sample T Test. Results: There was statistically significant improvement observed in the signs and symptoms of Madhumeha with blood and urine glucose levels. (p<0.05) Conclusion: Pugaarimeda Kashaya was found effective in the management of Madhumeha.
Standardization of Sneha Nasya Matra by Bindu Pramana of Taila and Ghrita
Authors: Preeti Chaturvedi  , Shubham Borkar  , Chhaya Baghel
Published: February 2023

In today’s due to lack of time, to prevent contamination, easy measurement, easy way of administration. Nasya Karma is administered on drop basis, which gives wrong interpretation. So, to achieve the optimum therapeutic effect, Nasya Karma is administered in Bindu Pramana. In this regard this study was adoptedto fix the dose.
Experimental evaluation of Chathusama Vati for its Anti-Diarrheal Activity
Authors: Revathy L  , Chaitra LV
Published: February 2023

Background: Diarrhea is the condition of having three or more loose or liquid bowel movements per day. The loss of fluids through diarrhea can cause dehydration and electrolyte disturbances such as potassium deficiency or other salt imbalance. According to the World Health Organization, diarrhea affects 3-5 billion people per year worldwide and cause 5 million death per year. It is an important health problem in all age groups and is a major cause of death in socio-economical backward class of people. Aim and Objective: An experimental evaluation of Chathusama Vati for its anti-diarrheal activity. Methods: The experimental study was a three-group experimental study, conducted on 6 different rats on each group. Total 18 healthy albino rats weighing between 150 gm to 200gm will be taken and divided randomly into three groups; Rats were induced diarrhea with castor oil orally. Rats of group 1 will be administered with distilled water served as control group. Group 2 will be administered with Loperamide 5 mg/kg. Group 3 will be administered with Chathusama Vati (Humandose×0.018). Results: In the experimental study the result was showed as the Chathusama Vati has significant action in Diarrhea. Conclusion: From the experimental study the result it was found that Chathusama Vati showed mild ant- diarrheal activity.
Management of Ekakushta vis-à-vis Chronic Plaque Psoriasis with Guduchi Kwatha and Karanja Taila - A Clinical Study
Authors: Dhanwantari Saste  , Mytrhey R C
Published: February 2023

The prevalence of skin diseases in general population has varied from 7.86% to 11.16% in various studies. All the skin diseases in Ayurveda have been discussed under the umbrella of “Kushta”. Kushta is further divided into Mahakushta and Kshudrakushta. Ekakushta is considered as one among the Kshudrakushta and it is Vata-Kapha Pradhana Vyadhi having Lakshana like Aswedana, Mahavastu and Matsya Shakalavat Twacha. Psoriasis is one of the most intriguing and perplexing disorder of skin. It is a papulosquamous disorder of the skin, characterised by sharply defined erythematous plaque lesions.  It is notoriously chronic and is well known for its cause or remission and exacerbation. Even though it is considered as an autoimmune disorder affecting the skin, it cannot always be treated as a somatic lesion, it is in fact multifactorial in origin and conditioned by various constitutional and environmental factors. A survey conducted by the National Psoriasis Foundation reports that, almost 75% of patients believe that psoriasis had moderate to large negative impact on their quality of life (QOL) with alterations in their daily activities. Guduchi Kwatha along with Karanja Taila which is specifically mentioned in Kushta Chikitsa, taken as intervention after the Virechana Karma.