bluuebunny/crossref_metadata_2025 huggingface dataset:
Tendencia del consumo de Vancomicina en Unidades de Cuidados Intensivos de Instituciones de Salud del Valle del Cauca
Authors: Castro Espinosa Jobany , De La Espriella Niño Carolina , Hoyos Ordoñez Karol , Izquierdo Viafara Britney
Published: December 2024

Introducción: La resistencia bacteriana es un problema de salud pública que impacta negativamente el control de enfermedades infecciosas, aumentando la morbi-mortalidad, la transmisión de infecciones y los costos asociados.
La Secretaría de Salud de Cali reportó resistencia bacteriana en pacientes de UCI en el Valle del Cauca, señalando un aumento en el consumo de Vancomicina, lo que representa un factor de riesgo para la resistencia bacteriana.
Objetivo: Describir el patrón de consumo de Vancomicina en instituciones de salud del Valle del Cauca de 2012 a 2020. 
Metodología: Estudio retrospectivo, longitudinal y descriptivo que evaluó el consumo de Vancomicina en UCI entre 2012 y 2020 en cinco municipios del Valle del Cauca. 
Se realizaron estadísticas descriptivas y la prueba de Kruskal-Wallis para comparar el consumo entre municipios, junto con análisis de series temporales para identificar tendencias y patrones estacionales. 
Resultados: Se observó variabilidad significativa en el consumo de Vancomicina entre municipios, siendo Palmira el de mayor consumo. 
La prueba de Kruskal-Wallis mostró diferencias significativas entre municipios (p < 0.001), y se identificaron picos estacionales en enero y julio. 
El análisis temporal reveló que Palmira y Tuluá presentaron patrones más fluctuantes y estacionales, mientras que Cali, Buga y Cartago mostraron tendencias más estables. 
Conclusiones: Se recomienda la implementación de protocolos homogéneos para el uso de Vancomicina en UCI y la planificación de recursos para los picos estacionales, con el fin de reducir la resistencia bacteriana.
Detalles del comportamiento psicométrico de escalas para medir calidad de vida en pacientes con heridas crónicas
Authors: García Hernandez Lila , Romo Pérez Camilo
Published: December 2024

Introducción: Las heridas crónicas, que interrumpen la continuidad del tejido epitelial y tienden a no cicatrizar adecuadamente, afectan gravemente la calidad de vida relacionada con la salud (CVRS) de los pacientes. 
Objetivo: Identificar y describir los instrumentos más utilizados para medir la calidad de vida relacionada con la salud en pacientes con heridas crónicas, evaluando sus propiedades psicométricas de fiabilidad, validez y utilidad. 
Métodos: Para identificar y evaluar las características psicométricas de los instrumentos más utilizados en la medición de la CVRS en pacientes con heridas crónicas, se realizó una revisión narrativa de la literatura en bases de datos como PubMed y Scopus. 
Se incluyeron estudios que evaluaran instrumentos genéricos y específicos, excluyendo aquellos centrados en otros tipos de heridas.
Resultados: Entre los instrumentos genéricos evaluados, el Índice de Calidad de Vida en Dermatología (DLQI) y el Euro-Qol-5D (EQ-5D) mostraron alta fiabilidad y validez. 
En cuanto a los instrumentos específicos, el Freiburg Life Quality Assessment for Wound Patients (FLQA-w) y el Wound-QoL destacaron por su alta consistencia interna y validez. 
El Cardiff Wound Impact Schedule (CWIS) y el Würzburg Wound Score (WWS) también demostraron ser herramientas válidas y fiables, aunque el WWS enfrenta desafíos en su aceptación por parte de los pacientes debido a su complejidad. 
Conclusión: La revisión identifica varios instrumentos robustos y validados para medir la CVRS en pacientes con heridas crónicas, facilitando la elección adecuada de herramientas en futuros estudios y prácticas clínicas.
EFEKTIVITAS PENERAPAN JAM TAMBAHAN DALAM CAPAIAN PEMBELAJARAN MATA KULIAH BAHASA INGGRIS MARITIM DI POLITEKNIK PELAYARAN MALAHAYATI TAHUN 2023
Authors: Arifin Syamsul , Farida Elly Kartika
Published: December 2024

ABSTRAK
Beraneka ragamnya bangsa di berbagai belahan dunia ini tentunya juga memiliki beraneka ragam adat, budaya dan Bahasa pula. Oleh karena itu, agar tidak terhalangnya komunikasi antar berbagai negara di dunia ini maka dipergunakanlah Bahasa internasional sebagai Bahasa dalam berkomunikasi. Bahasa inggris merupakan salah satu Bahasa internasional yang sering di pergunakan di berbagai negara. Karena negara inggris merupakan salah satu negara yang pernah menjajah hampir sebagian besar negara yang ada di dunia. Oleh karena itu tidak heran jika banyak sekali negara yang menggunakan Bahasa inggris sebagai Bahasa dalam berkomunikasi sehari-hari.
Pelaut adalah sebuah profesi yang memiliki wilayah kerja tidak terbatas. Seorang pelaut bekerja dari satu Pelabuhan ke Pelabuhan lain, dari satu negara ke negara lain. Oleh karena itu pelajaran Bahasa inggris adalah pelajaran yang sangat penting dan harus di kuasai oleh para pelaut. Di dalam kurikulum pembelajaran pada sekolah kedinasan kementerian perhubungan terdapat sebuah mata kuliah yaitu Bahasa inggris maritim. Mata kuliah ini adalah modal utama bagi seorang pelaut agar bisa berkomunikasi dengan baik ketika akan bekerja di atas kapal bersama rekan kerja dari berbagai negara. Mengingat begitu pentingnya mata kuliah ini, maka khusus untuk mata kuliah ini diberikan jam tambahan di luar jam pembelajaran wajib yaitu kegiatan pembelajaran tambahan pada pagi dan sore hari. Hal ini dilakukan agar semakin banyak waktu yang di alokasikan untuk melatih para taruna/i dalam berkomunikasi menggunakan Bahasa inggris untuk mendukung pendidikan vokasi di Politeknik Pelayaran Malahayati. Penelitian ini menggunakan pendekatan kuantitatif deskriptif dimana Informan dalam penelitian ini adalah para taruna/i program Diploma III yang sedang mengambil mata kuliah Bahasa inggris maritim di Politeknik Pelayaran Malahayati, tenaga pendidik yaitu dosen pengampu mata kuliah Bahasa inggris maritim Program Diploma III. Metode pengumpulan data yang akan digunakan dalam penelitian adalah kuesioner, wawancara dan dokumentasi.
ANALISA FATIGUE LIFE PROPELLER PADA KAPAL LATIH MALAHAYATI ACEH
Authors: Kurniawan Dedi , Alberto Alberto , Nurman Salfauqi , Herlambang Agus
Published: December 2024

Propeller merupakan salah satu komponen penting karena tanpanya sebuah kapal tidak akan bisa melakukan fungsi dan kegunaannya. Namun, sebuah baling-baling kapal harus memiliki kemampuan yang cukup dalam menopang gaya-gaya yang bekerja terhadapnya secara terus-menerus, yang dapat mengaki-batkan terjadinya keretakan dan akhirnya mengalami kepatahan. Analisa fatigue life propeller pada Kapal Latih Malahayati Aceh diperlukan untuk dapat mengetahui batas waktu  sehingga dapat menghindari ter-jadinya deformasi dan juga kemungkinan kecelakaan kerja pada saat kapal latih tersebut beroperasi. Pem-bebanan yang diberikan didapat dari hasil contour pressure pada analisa CFD terlebih dahulu yang kemudian di-running dengan menggunakan Metode Elemen Hingga (MEH) untuk mendapatkan Hot Spot Stress. Hasilnya didapatkan Hot Spot Stress sebesar 3,515 x 1011 Pa yang berlokasi di daerah root suc-tion back propeller akibat perbedaan tekanan yang cukup signifikan pada bagian face dan back propeller. Nilai tegangan tersebut dapat digunakan untuk mendapatkan life cycle minimum sebesar 3,32 x 109 cycle yang kemudian didapatkan umur dari material selama 32,21 tahun.
PENGARUH LAMA WAKTU PENUMPUKAN PETIKEMAS IMPOR INTERNASIONAL TERHADAP BESARAN TARIF YANG HARUS DIBAYARKAN OLEH PENGGUNA JASA DI PT. X
Authors: Maulana Wildan Akbar , Kusumawati Elly , Susanto Novrico , Putri Indah Ayu Johanda
Published: December 2024

Lamanya penumpukan petikemas yang terkena behandle Bea Cukai dan karantina yang menyebabkan kenaikan tarif penumpukan dan menyebabkan pengguna jasa mengajukan restitusi kepada perusahaan. Tujuan penelitian ini adalah untuk mengetahui pengauh lama waktu penumpukan petikemas terhadap tarif, serta mengetahui seberapa besar minat pengguna jasa dalam mengajukan keringanan biaya penumpukan. Penelitian ini menggunakan metode deskriptif kuantitatif dengan menggunakan teknik analisis regresi linier sederhana dan teknik penskoran. Teknik pengumpulan data dalam penelitian ini mnggunakan wawancara, kuesioner observasi, dokumentasi. Pengolahan data dalam penelitian ini menggunakan SPSS for windows ver. 26 dan teknik penskoran data. Hasil dari penelitian ini adalah pengaruh antara lama waktu penumpukan terhadap tarif penumpukan yakni sebesar 55,9%. pengguna jasa yang mengajukan restitusi sebesar 58,33 %., sedangkan pengguna jasa yang tidak mengajukan restitusi sebesar 41,66%. Meningkatnya pengguna jasa yang mengajukan restitusi di akibatkan pengguna jasa merasa terbebani dengan biaya penumpukan yang di akibatkan dwelling time yang lama.
Influence of a Multimodal Psychosomatic Therapy Concept with Exercise Focus on Depressive Symptoms as well as Hemodynamic Parameters and Heart Rate Variability in Depressive Patients
Authors:   nstitut für Sportwissenschaft, Martin-Luther-Universität Halle-Wittenberg, Halle, Germany, S Ketelhut
Published: December 2024

The prevalence of depression increased over the
past decades. In addition to primary symptoms, depressed patients
often have an increased cardiovascular risk profile. To address these
relations, the present study examined the effects of a multimodal
psychosomatic therapeutic concept with a major focus of regular
exercise on hemodynamics, cardiac autonomic function and selfassessment in depressed patients.
Unified Growth: Empowering University Graduate Students through Online Supervision, Collaboration and Mentorship
Authors: Owino Elizabeth , Donald Lwala Dick
Published: December 2024

Thesis supervision is one of the critical responsibilities of a supervisor. A graduate student’s supervisor can be compared to a family doctor. Even though the doctor may have many patients, striving to know the needs of each patient is vital in meeting their needs. Likewise, being knowledgeable and competent, a doctoral supervisor is expected to know each doctoral student’s immediate needs. This qualitative case study explored the role of mentorship and collaboration strategies in the scholarly and professional development of graduate students. Purposive sampling was done and focused on the communication platform used by graduate students and faculty. Data was analyzed using thematic content analysis. The study findings indicated that through mentorship graduate students received guidance, support, and encouragement that is critical in graduate studies. Additionally, collaboration among the students and between the students and the supervisors offers valuable insights into research development, self-development, networking, and career planning.
Participatory Action Research on Canadians with Alternatively Diagnosed Lyme Disease: Feasibility Study
Authors: Chevalier Jacques , Larose Zélie
Published: December 2024

This feasibility study provides background information on the problem of Lyme Disease (LD) underestimations in Canada, as well as the Federal Framework recommendation to collect human health data for Canadian residents “who do not meet the case definition for probable or confirmed LD, but who experience various symptoms consistent with LD or similar ailments.” This is followed by a summary of how the Public Health Agency of Canada (PHAC) assessed the agency’s progress in implementing the recommendation over a four-year period beginning in 2017 and ending in 2021. The study then provides a brief description of the mandate issued by PHAC to the consultant team by the end of 2021. It describes the methodology followed in assessing the feasibility of PHAC’s proposed initiative, which is to use a Participatory Action Research (PAR) approach to improve knowledge and inform future public health actions for Canadians diagnosed with Lyme disease (LD) via alternative means. The overall conclusions of the report are based on interviews with PHAC’S external partners and discussions of feasibility and success factors. They are organized by three sets of interview questions: project goals, rules of engagement, and data collection methods. The conclusion summarizes the study and offers suggestions on how to proceed with the project’s next phase.
International og dansk praksis i notationen af lukkelyde
Authors: Puggaard-Rode Rasmus
Published: December 2024

Konventionerne for dansk lydskrift er blevet debatteret meget de seneste år, og et særligt kontroversielt aspekt ved denne debat er notationen af de danske lukkelyde. Kontroversen er ikke forårsaget af en egentlig uenighed om hvordan de danske lukkelyde udtales, men rettere om hvilke aspekter af lukkelydenes udtale som det er vigtigst at repræsentere i lydskrift, og dermed også hvilket formål lydskriften bør tjene. Denne artikel diskuterer og evaluerer de forskellige forslag med baggrund i den instrumentalfonetiske forskning og internationale praksis på området med fokus på uenighederne i debatten. I den sammenhæng gives et generelt overblik over hvordan lukkelyde noteres med det internationale fonetiske alfabet (IPA) på verdens sprog. Artiklen viser at den gængse danske notationskonvention med symbolerne [b̥ d̥ g̊ pʰ tˢ kʰ] er usædvanlig i forhold til international brug af IPA, og den argumenterer for at konventionen i nogle henseender er uhensigtsmæssig fordi der ikke er nogen klar international konsensus om hvordan flere af tegnene skal tolkes. Jeg argumenterer desuden imod at IPA’s moderorganisation skulle være autoritativ når det kommer til fonologisk analyse, og derfor også når det kommer til brugen af fonemisk notation i skråklammer / /.
Sin og deres med flertalsantecedenter i KorpusDK
Authors: Ehlers Katrine Rosendal
Published: December 2024

Det danske possessive refleksiv sin (herunder sit og sine) har i mindst 800 år primært optrådt med entalsantecedenter og ikke flertalsantecedenter. Det hedder i moderne standarddansk at Hun kørte hjem i sin bil, men Karen og Per kørte hjem i sin deres bil. Langt overvejende bruges deres frem for sin når subjektsantecedenten er flertal. Det er dog ikke usædvanligt at høre eller læse sin brugt med flertalsantecedent i moderne dansk, også i mere formelle kontekster. I denne artikel undersøger jeg forekomsten af sin med flertalsantecedenter i KorpusDK. Jeg bygger min undersøgelse på en manuel gennemlæsning af ca. 55.000 sætninger fra korpusset og kan sige med sikkerhed at meget tæt på alle eksempler på sin med flertalsantecedent i KorpusDK er inkluderet i undersøgelsen. Undersøgelsen afdækker først og fremmest at sin faktisk optræder med flertalsantecedenter i det relativt formelle skriftsprogskorpus, omend det stadig er deres der er langt den hyppigst brugte form. Jeg har undersøgt hvorvidt eksemplerne på sin med flertalsantecedent optræder syntaktisk og semantisk som (i) refleksivt deres, som (ii) sin med entalsantecedent, eller som (iii) sin helt egen kategori. Brugen af sin med flertalsantecedent skiller sig ud blandt andet i forhold til animathed og distributivitet. Jeg konkluderer at sin med flertalsantecedent er en systematisk forekommende variant i korpusset og ikke ’bare’ en kongruensfejl.
MULTI-OBJECTIVE PARAMETRIC OPTIMISATION OF MASKED STEREOLITHOGRAPHY ADDITIVE MANUFACTURING USING THE RESPONSE SURFACE METHOD
Authors: Dicks James Anthony , Hoosain Mohammed Imran , Mbele Onkhopotse
Published: December 2024

Masked stereolithography is an effective and economical additive manufacturing technology that is suitable to fabricate objects for engineering applications. As such, parametric optimisation to attain good mechanical properties is of value in order to realise its full potential. A multi-objective optimisation of the printing parameters of masked stereolithography 3D printing for mechanical properties was performed using central composite design for response surface method analysis. The developed response surfaces were used to perform numerical optimisation to establish appropriate printing parameters, which were validated against experimental results and compared with bulk polymer specimen mechanical properties. Here, an optimised layer cure time of 3.8 s, a layer height of 50 μm, and a post-curing time of 13.5 min resulted in mechanical properties closely predicted by the model and near to bulk polymer specimen properties. Last, the optimisation results were related to a Jacobs working curve, which established that layer cure times beyond that determined by the Jacobs working curve were favoured.
Note from the Editor
Authors: Schutte Corne
Published: December 2024

2024 had come to an abrupt end, and this is the final edition for 2024. At the end of 2023, we were still living with the effects of COVID, and continuous load shedding. But life had moved on! Load shedding is (for now at least) history. South Africa had elections in 2024, and a new Government of National Unity was established, and with that, a lot of new optimism about the future! Logistics and the broken rail network are still issues, but you can see how industrial engineering professionals are adapting to these new challenges to find solutions.

As mentioned at the end of 2017, it is now customary to evaluate how the journal is performing. Scopus (www.scopus.com) measures impact with a “CiteScore”. The CiteScore for a year is calculated as the Citation Count for the year / number of documents published in the previous three years. The Citescore for 2022 was 1.4, in 2023 it was 1.1 and 2024 is projected to be 1.2 . Our ranking with respect to the Percentile in the category, is currently stable as a Q3 journal.

Another important source for journal standing, is Scimago Journal and Country Rank (www.scimagojr.com), where the journal is also listed as a Q3 journal in the “Industrial and Manufacturing Engineering” subject area. It is very encouraging to observe how the number of citations per document has grown (Figure 1).
Decyzja o wstrzymaniu użytkowania dużego obiektu energetycznego spalania – ważenie interesu publicznego i prywatnego
Authors:   Uniwersytet Łódzki: Wydział Prawa i Administracji, Pogorzała Wiktoria , Pytkowski Michał ,   Uniwersytet Łódzki: Wydział Prawa i Administracji
Published: December 2024

Celem artykułu jest analiza, w jakim stopniu i czyim interesem powinien się kierować organ inspekcji ochrony środowiska, podejmując decyzję o wstrzymaniu użytkowania instalacji dużego obiektu energetycznego spalania. Badaniu poddano jedynie postępowanie w oparciu o art. 367 ustawy z dnia 27 kwietnia 2001 r. – Prawo ochrony środowiska z tego względu, że fakultatywny charakter tego postępowania w połączeniu z możliwością wyznaczenia dodatkowego terminu na usunięcie naruszeń jedynie na wniosek strony budzi wątpliwości autorów niniejszego artykułu w zakresie ważenia interesów publicznego i prywatnego. W analizowanym postępowaniu interes publiczny przejawiający się w obowiązku ochrony środowiska ujęty w art. 5 i 74 Konstytucji RP jest przeciwstawiany interesowi prywatnemu, w głównej mierze wyrażonemu w art. 20–22 oraz 31 Konstytucji RP, tj. zasadom własności prywatnej i swobody działalności gospodarczej. Organ inspekcji ochrony środowiska każdorazowo musi dokonać wnikliwej analizy, przykładając stan faktyczny danej sprawy do wytycznych zawartych w powyżej wskazanych artykułach Konstytucji RP, kierujących rozstrzygnięcie w przeciwnych kierunkach. Autorzy niniejszego artykułu wskazują, że w szczególności w przypadku dużych obiektów energetycznego spalania, interes użytkowników tych instalacji doznaje nieuzasadnionego uszczerbku przejawiającego się specyfiką procedury postępowania o wstrzymanie użytkowania instalacji w oparciu o art. 367 prawa ochrony środowiska.
Wpływ wejścia w życie MiFID II na ryzyko funkcjonowania spółek energetycznych w Polsce
Authors: Hawranek Paweł , Michalski Dariusz ,   Akademia Techniczno-Humanistyczna w Bielsku Białej, Borkowski Daniel
Published: December 2024

Wprowadzenie regulacji MiFID II wymagało implementacji tej dyrektywy do krajowego porządku prawnego z uwzględnieniem pewnej odrębności regulacji krajowych. Niestety do implementacji nie doszło przed wejściem w życie dyrektywy. Brak implementacji spowodował po stronie przedsiębiorstw energetycznych biorących udział w hurtowym obrocie towarowym wystąpienie ryzyka regulacyjnego związanego z brakiem pewności co do ostatecznego kształtu implementacji. Czas vacatio legis dyrektywy zamiast wykorzystania go na dostosowywanie struktury przedsiębiorstw energetycznych upłynął na oczekiwaniu na pojawienie się przepisów transponujących. W konsekwencji przedsiębiorstwa energetyczne otrzymały niezwykle mało czasu na dostosowanie swoich struktur do nowych wymogów regulacyjnych. Równocześnie zobligowane były do prowadzenia swojej działalności w oparciu o niezmienione przepisy ustawy o obrocie instrumentami finansowymi, przy pełnej świadomości nieuchronności wprowadzenia istotnych zmian, w tym nałożenia obowiązków reglamentacyjnych, z krótkim terminem ich wejścia w życie. Wszystko powyższe spowodowało, iż świadome zagrożeń przedsiębiorstwa energetyczne do czas pełnego ukształtowania się ładu post-Mifidowego i praktyki działania, a zwłaszcza podejścia regulatora do nowych wymogów, podjęły szereg działań w celu przygotowania się do stosowania nowej regulacji.
Umowa o przyłączenie do sieci ciepłowniczej w świetle prawa ochrony konkurencji i konsumentów
Authors: Sroczyński Jarosław , Staszek Agnieszka
Published: December 2024

Artykuł przedstawia zagadnienie zawierania umów o przyłączenie do sieci ciepłowniczej z perspektywy prawa ochrony konkurencji i konsumentów. Omówiono obowiązki spoczywające na przedsiębiorstwie energetycznym, przede wszystkim obowiązek przyłączenia do sieci ciepłowniczej nowych odbiorców. Kluczową kwestią przedstawioną w artykule jest rozkład ryzyka pomiędzy przedsiębiorstwem ciepłowniczym i przyłączanym podmiotem, jeżeli pierwotne zamierzenia inwestora, w szczególności dewelopera, okazują się niewykonalne. Nadmierne zabezpieczenie się przedsiębiorstwa ciepłowniczego na taką okoliczność może skutkować zarzutem nadużycia pozycji dominującej, a próba przerzucenia ryzyka na odbiorców – konsumentów, zarzutem naruszenia zbiorowych interesów konsumentów. Trudno jednak oczekiwać od przedsiębiorstwa ciepłowniczego, aby przejęło na siebie całość ryzyka inwestycyjnego związanego z nowymi przyłączeniami. Wyważenie właściwych proporcji pomiędzy sprzecznymi interesami stron powinno być kształtowane poprzez rozwój orzecznictwa organów ochrony konkurencji i konsumentów.
Szerokie podejście Komisji Europejskiej i Prezesa UOKiK do nagradzania współpracy przedsiębiorców w toku postępowania w sprawie praktyk ograniczających konkurencję
Authors: Zawłocka-Turno Agata
Published: December 2024

Artykuł przedstawia ostatnią praktykę orzeczniczą Komisji Europejskiej wskazującą na tendencję do szerokiego, wychodzącego poza obecne ramy proceduralne (czyli leniency, settlements i decyzji zobowiązującej), premiowania przedsiębiorców za współpracę przyczyniającą się do szybszego zakończenia postępowania. Prezentuje również podejście Prezesa UOKiK do nagradzania współpracy. Ponadto artykuł analizuje czy szeroki negocjacyjny model stosowania prawa ochrony konkurencji nie niesie ryzyka dla efektywności egzekwowania reguł konkurencji.
O dostępnych trybach emisji obligacji
Authors: Szewczyk Jarosław
Published: December 2024

Przedmiotem artykułu jest analiza przepisów regulujących dopuszczalne „tryby” emitowania obligacji w kontekście przepisów rozporządzenia prospektowego, tj. rozporządzenia Parlamentu Europejskiego i Rady (UE) 2017/1129 z dnia 14 czerwca 2017 r. w sprawie prospektu, który ma być publikowany w związku z ofertą publiczną papierów wartościowych lub dopuszczeniem ich do obrotu na rynku regulowanym oraz uchylenia dyrektywy 2003/71/WE. Od 21 lipca 2019 r. w polskim porządku prawnym pojawił się nowy reżim dla publicznego oferowania papierów wartościowych. Nowy akt prawny zmienił zasady sporządzania prospektów, ale przede wszystkim zrewolucjonizował pojęcie „oferty publicznej”. Nowa definicja oferty publicznej rzutuje na wiele dziedzin rynku kapitałowego, w tym także na przepisy regulujące tryb emitowania (oferowania) obligacji inwestorom.
Effect of Microbially Available Phosphorous Limitation on Microbiological Water Quality in Internal Drinking Water Supply
Authors:   , Zemīte Marta
Published: December 2024

Phosphorus limitation reduces bacterial growth and biofilm formation, which can aid in controlling the growth of potentially pathogenic microorganisms. However, information on the effects of phosphorus reduction within internal drinking water systems, where water quality deterioration frequently occurs, remains limited. This study investigates the limitation of microbially available phosphorus in internal drinking water supply, using a granular ferric hydroxide sorption filter, and evaluates its impact on such opportunistic premise plumbing pathogens as Legionella bacteria.
Burial Complex Isteekh Byraan (Central Yakutia): Physical and Geographical Conditions, Geocryological Conditions, Toponyms, and Narrative of the Natural Environment.
Authors: Prokopieva Aleksandra Nikolaevna
Published: December 2024

The subject of this research is the burial complex Isteekh Byraan, located on the terraces of the right bank of the Lena River and in part of the adjoining valley. The complex consists of several cemeteries from different time periods, integrated into the natural landscape: this includes the top of the terrace, its southern foothills, and the high bank of the stream flowing beneath the terraces. The focus of the study is the burial complex and historical events in the context of the natural landscape. The aim is to establish a connection between historical events, individuals, and the names of places within the natural landscape, as well as to introduce field materials into circulation. Data on the physical and geographical conditions of the burial complex have been summarized, as the natural factor may have played a significant role in the choice of this area as a burial site. Oral material regarding microtoponyms and the narrative of the monument was collected from local residents, and discussions were held during scientific and practical conferences and round tables dedicated to the history of the Khangalassky ulus. The complex terrain of the area, which had developed by the time the pasture settlers inhabited it, determined the location of the burial sites. It is likely that the picturesque landscapes corresponded to aesthetic and religious beliefs, as the burial complex and residential areas are located nearby. It was discovered that some of the existing microtoponyms can be attributed to earlier layers and have lost their meaningful significance. It is likely that the preserved oral tradition reflects previously existing rules of land distribution and inheritance among the local nobility and aristocracy. The study has demonstrated the potential of this direction and could be expanded into a collaborative interdisciplinary study of the monument.
On intuitionistic fuzzy chained modules
Authors: Sharma Poonam Kumar
Published: December 2024

In this paper, we introduce and explore some novel concepts within the frame work of intuitionistic fuzzy module theory. First, we define the notion of an intuitionistic fuzzy chained module as a generalisation of chained modules, establishing it foundational properties. We then characterise intuitionistic fuzzy chained modules, in terms of its level-cut submodules. In addition to this, we describe an intuitionistic fuzzy chained module in terms of its intuitionistic fuzzy cyclic submodules. Finally, we demonstrate that under specific conditions, the intuitionistic fuzzy multiplication module is an intuitionistic fuzzy chained module.
Intuitionistic fuzzy Nakayama’s Lemma
Authors: Achik S. , Bakhadach I. , Oukessou M. , Melliani S.
Published: December 2024

Drawing upon Atanassov's pioneering work on intuitionistic fuzzy sets [1], this paper presents the concept of intuitionistic fuzzy Nakayama's Lemma, offering a natural extension to Rajesh Kumar et al.'s fuzzy Nakayama's Lemma [8]. Additionally, we define the intuitionistic fuzzy Jacobson radical and explore the product of an intuitionistic fuzzy ideal and intuitionistic fuzzy submodule. Finally, we conclude by introducing the sum of two intuitionistic fuzzy submodules.
Inclusion measure for intuitionistic fuzzy sets and embedding of intervals
Authors: Bruteničová Michaela , Janiš Vladimír
Published: December 2024

Comparison of measuring the degree of inclusion for two intuitionistic fuzzy sets (IF-sets) and measuring the degree of embedding of two intervals is considered. Embedding is understood as the classical inclusion of intervals. Inclusion of IF-sets is based on a specific order. In case that the nonmebership function does not exceed the membership function in an IF set, and we replace formally the IF-set by an interval-valued fuzzy set, then the inclusion of IF-sets corresponds to an embedding of interval-valued sets. The embedding measure for interval-valued fuzzy sets was defined previously and we compare the concept of embedding with the inclusion of IF-sets.
Comparison study based on the divergence measures between intuitionistic fuzzy sets and some applications
Authors: Kobza Vladimír
Published: December 2024

Many authors investigated possibilities how two fuzzy sets can be compared. The basic study of fuzzy sets theory was introduced by Lotfi Zadeh in 1965. The previous approach to the dissimilarities is too restrictive, because it assumes the inclusion relation between fuzzy sets and many pairs of fuzzy sets are incomparable to each other with respect to this relation. Therefore we need new concept for measuring - divergence measures. We discuss the divergences defined on more general objects, namely intuitionistic fuzzy sets (IFSs). We have focused on some applications of this concept to pattern recognition and to decision making. In both cases, we present an illustrative example.
UBR-1 deficiency leads to ivermectin resistance in C. elegans
Authors: Li Yi , Gong Long , Wu Jing , Hung Wesley , Zhen Mei , Gao Shangbang
Published: December 2024

Resistance to anthelmintics, particularly the macrocyclic lactone ivermectin (IVM), presents a substantial global challenge for parasite control. We found that the functional loss of an evolutionarily conserved E3 ubiquitin ligase, UBR-1, leads to IVM resistance in
Caenorhabditis elegans
. Multiple IVM-inhibiting activities, including viability, body size, pharyngeal pumping, and locomotion, were significantly ameliorated in various
ubr-1
mutants. Interestingly, exogenous application of glutamate induces IVM resistance in wild-type animals. The sensitivity of all IVM-affected phenotypes of
ubr-1
is restored by eliminating proteins associated with glutamate metabolism or signaling: GOT-1, a transaminase that converts aspartate to glutamate, and EAT-4, a vesicular glutamate transporter. We demonstrated that IVM-targeted GluCls (glutamate-gated chloride channels) are downregulated and that the IVM-mediated inhibition of serotonin-activated pharynx Ca
2+
activity is diminished in
ubr-1
. Additionally, enhancing glutamate uptake in
ubr-1
mutants through ceftriaxone completely restored their IVM sensitivity. Therefore, UBR-1 deficiency-mediated aberrant glutamate signaling leads to ivermectin resistance in
C. elegans
.
Altruisme versus egennytte:
Authors: Borge Baard Herman , Hagebakken Grete , Lindrupsen Cathrine , Thorsen Sunniva
Published: December 2024

I denne artikkelen undersøker vi hva som, tross lave søkertall og negativ medieomtale, motiverer unge mennesker til å studere sykepleie. Studien setter søkelys på skillet mellom altruistisk og egennyttig motivasjon, og sammenligner dessuten sykepleiestudenter på bakgrunn av deres kjønn, alder, tidligere arbeidserfaring og hvilken prioritet de ga studiet da de søkte.
Kvantitative data ble samlet inn i en digital spørreundersøkelse våren 2023, og analysert med SPSS 29. Hypotesene ble testet ved hjelp av Pearson korrelasjon, F- og t-test. Utvalget besto av 109 sykepleiestudenter ved to utdanningsinstitusjoner, som selv valgte å delta. Altruistisk og egennyttig motivasjon ble operasjonalisert i form av 16 påstander, som igjen ble brukt til å konstruere to indekser.
Resultatene tyder på at sykepleierstudenter motiveres av både altruistiske og egennyttige motivasjonsfaktorer, men med en overvekt av altruistisk motivasjon. De to dimensjonene står ikke i et motsetningsforhold til hverandre. Det var liten forskjell i motivasjonen til ulike grupper. Den eneste av de undersøkte bakgrunnsvariablene som ga signifikant utslag var tidligere erfaring fra omsorgsarbeid. 
Empiri som belyser studentenes motivasjon, kan bidra til mer målrettet rekrutteringsarbeid. Dagens sykepleierstudenter fremstår som en homogen gruppe med hensyn til motivasjon, men studien reiser samtidig spørsmål om deres vekt på altruistiske verdier skiller dem fra andre utdanningssøkere.  Hvis ungdommens egenorientering forsterkes, mens altruismen svekkes, kan man forvente enda større utfordringer med rekruttering av sykepleierstudenter i fremtiden. En slik situasjon vil medføre behov for ytterligere nytenkning for at yrket skal gjøres attraktivt for nye generasjoner.
N6-methyladenosine (m6A) modification in inflammation: a bibliometric analysis and literature review
Authors: Li Zewen , Lao Yongfeng , Yan Rui , Guan Xin , Bai Yanan , Li Fuhan , Dong Zhilong
Published: December 2024

N6-methyladenosine (m6A) is the most abundant internal messenger RNA modification in eukaryotes, influencing various physiological and pathological processes by regulating RNA metabolism. Numerous studies have investigated the role of m6A in inflammatory responses and inflammatory diseases. In this study, VOSviewer and Citespace were used to perform bibliometric analysis to systematically evaluating the current landscape of research on the association between m6A and inflammation. The literature was sourced from the Web of Science Core Collection, with characteristics including year, country/region, institution, author, journal, citation, and keywords. According to the bibliometric analysis results of keywords, we present a narrative summary of the potential mechanisms by which m6A regulates inflammation. The results showed that the key mechanisms by which m6A modulates inflammation include apoptosis, autophagy, oxidative stress, immune cell dysfunction, and dysregulation of signaling pathways.
Effects of prophylactic nebulized antibiotics on the prevention of ICU-acquired pneumonia: a systematic review and meta-analysis
Authors: Gao Ming , Yu Xiaoxu , Liu Xiaoxuan , Xu Yuan , Zhou Hua , Zhu Yan
Published: December 2024

Objective

To evaluate the efficacy and safety of prophylactic nebulized antibiotics in preventing intensive care unit (ICU)-acquired pneumonia through a meta-analysis.

Methods

Randomized controlled trials (RCTs) investigating the potential reduction in the incidence of ICU-acquired pneumonia through prophylactic nebulized antibiotics were collected by searching the PubMed, Embase, and Cochrane Library databases from their inception to January 23, 2024. The primary endpoint was the incidence of ICU-acquired pneumonia, while the secondary endpoints included mortality, length of ICU stay, mechanical ventilation days, and nebulization-related side effects. Statistical analyses were performed using RevMan 5.3 and STATA 14.0 software.

Results

A total of six RCTs were included in the analysis, involving 1,287 patients (636 patients in the study group received prophylactic antibiotic therapy, including Polymyxin B, Tobramycin, Ceftazidime, Colistimethate sodium, and amikacin; 651 patients in the control group primarily received saline). The results indicated that prophylactic nebulized antibiotic therapy significantly reduced the incidence of ICU-acquired pneumonia compared to that in the control group (odds ratio (OR) = 0.57, 95% confidence interval (CI) [0.43–0.74], P < 0.0001). No significant difference was observed in the mortality rate between the treatment and control groups (OR = 0.86, 95% CI [0.68–1.10], P = 0.24). Prophylactic nebulized antibiotic therapy also did not significantly reduce the length of ICU stay (MD = 0.2 days; 95% CI [−0.81 to 1.20], P = 0.70) or the number of mechanical ventilation days (MD = 0.43 days; 95% CI [−0.47 to 1.33], P = 0.35). Additionally, there was no evidence that prophylactic nebulized antibiotic therapy contributed to the development of multiple drug-resistant (MDR) bacterial pneumonia or increased the incidence of associated side effects, such as airway spasms.

Conclusions

This meta-analysis suggests that ICU-acquired pneumonia can be prevented by prophylactic nebulized antibiotic therapy in critically ill patients without increasing the risk of MDR bacterial infections or airway spasms. However, the reduction in the incidence of ICU-acquired pneumonia did not result in significant improvements in mortality or length of ICU stay.
Identification of immunogenic cell death gene-related subtypes and risk model predicts prognosis and response to immunotherapy in ovarian cancer
Authors: Pan Wenjing , Jia Zhaoyang , Zhao Xibo , Chang Kexin , Liu Wei , Tan Wenhua
Published: December 2024

Background

Immunogenic cell death (ICD) has been associated with enhanced anti-tumor immunotherapy by stimulating adaptive immune responses and remodeling the immune microenvironment in tumors. Nevertheless, the role of ICD-related genes in ovarian cancer (OC) and tumor microenvironment remains unexplored.

Methods

In this study, high-throughput transcriptomic data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases as training and validation sets separately were obtained and proceeded to explore ICD-related clusters, and an ICD-related risk signature was conducted based on the least absolute shrinkage and selection operator (LASSO) Cox regression model by iteration. Multiple tools including CIBERSORT, ESTIMATE, GSEA, TIDE, and immunohistochemistry were further applied to illustrate the biological roles of ICD-related genes as well as the prognostic capacity of ICD risk signature in OC.

Results

Two ICD-related subtypes were identified, with the ICD-high subtype showing more intense immune cell infiltration and higher activities of immune response signaling, along with a favorable prognosis. Additionally, four candidate ICD genes (IFNG, NLRP3, FOXP3, and IL1B) were determined to potentially impact OC prognosis, with an upregulated expression of NLRP3 in OC and metastatic omental tissues. A prognostic model based on these genes was established, which could predict overall survival (OS) and response to immunotherapy for OC patients, with lower-risk patients benefiting more from immunotherapy.

Conclusion

Our research conducted a prognostic and prediction of immunotherapy response model based on ICD genes, which could be instrumental in assessing prognosis and assigning immunotherapeutic strategies for OC patients. NLRP3 is a promising target for prognosis in OC.
Virtual reality therapy in managing cancer pain in middle-aged and elderly: a systematic review and meta-analysis
Authors: Chen Yang , Meng Hui , Chen Qian , Wu Wendong , Liu HaiBin , Lv Shi , Huai Liang
Published: December 2024

Background

Virtual reality technology has been proposed to rehabilitate cancer patients. This study aimed to summarize the effectiveness of virtual reality (VR)--based therapies for pain management in middle-aged and elderly cancer patients.

Methods

This meta-analysis was registered in PROSPERO (CRD42023400432). We searched the randomized controlled trials (RCTs) in PubMed, Scopus, the Cochrane Library, Web of Science, and Embase, conducted from construction until November 1, 2024. The study examined the effects of VR treatment on pain levels in middle-aged and elderly cancer patients using RCTs as primary or secondary outcome measures. Articles were evaluated for eligibility according to predetermined criteria, and each of the three researchers independently collected the data. The researchers used the heterogeneous selection effects model to calculate the mean effect sizes.

Results

This meta-analysis included seven RCTs involving 476 patients. The meta-analysis confirmed the significant effect of VR therapy on the management of pain, anxiety, and depression in the middle-aged and elderly cancer population.

Conclusions

Our research shows that VR could be a significant device for cancer pain management in the middle-aged and elderly and that VR scene therapy may be more effective. Nevertheless, it is essential to use caution when interpreting the findings since the number of research included is small.
Delitos apologéticos a través de las TIC: suicidio, autolesión, trastornos alimentarios y abuso sexual a menores y personas con discapacidad
Authors: Boldova Pasamar Miguel Ángel
Published: December 2024

Se han incorporado al Código penal español nuevas figuras delictivas vinculadas a las tecnologías de la información y la comunicación (TIC). Se prohíbe la difusión pública de mensajes específicamente destinados a inducir al suicidio, la autolesión o a provocar trastornos alimentarios en menores y personas vulnerables, así como los mensajes que hacen apología de la pederastia. Dichos delitos se presentan como una novedad en el propio Derecho comparado, en el que se dan pasos en el mismo sentido. Se plantea la relevancia de estas conductas y la eficacia que cabe esperar de su aplicación práctica.
Influence of Secondary and Micro Nutrients Status of Soils on Grape Yield of Vineyards in Northern Dry Zone of Karnataka, India
Authors: Vishwasagar K. , H. Yogeeshappa, , Kurubetta Krishna , Nidagundi Rajeshwari , Jaggal Somappa S , Chandalinga.
Published: December 2024

A studywas conducted to study the influence of secondary and micro nutrients status of soils on grape yield of vineyards during the year 2019-20 in Yelburga taluk of Koppal district. Based on the previous year yield data, the thirty vineyards were classified into three groups namely, low yielding vineyards (LYV), medium yielding vineyards (MYV) and high yielding vineyards (HYV). The soil samples collected after harvest of crop recorded slight increase in the exchangeable Ca and Mg content compared to the soil samples collected before October pruning. The HYV [11.16± 2.61 and 12.08±2.76 c mol (p+) kg-1] soils recorded higher calcium content compared to other groups in both the sampling seasons respectively. HYV [6.81± 1.26 and 6.88 ± 1.19 c mol (p+) kg-1] recorded highest exchangeable Mg content compared to other two groups in both the sampling seasons respectively. The sulphur content in group HYV was significantly higher (51.67 ± 16.46 and 64.09 ± 18.59mg kg-1) as compared to the other groups at before October pruning and at after harvest, respectively. Distribution of micronutrients in soil samples collected before October pruning and after harvest were found in the order Mn > Fe > Zn > Cu. Vineyard soil sample showed medium to high content of micronutrients. The concentration of DTPA extractable micronutrients among three groups of vineyards differed significantly. The differences in yields of vineyards is depends on soil fertility status. Hence, it is important to adopt good nutrient management practices to ensure sustainable grape yields in vineyards.
Advancing Precision Agriculture: The Role of UAVs and Drones in Sustainable Farming
Authors: Barve Aniruddha N. , Lajurkar Manik R. , Kharbade S. B. , Bagde A. S. , Waghmare S. J. , Karande R. A. , Sathe Snehal N.
Published: December 2024

Modern sustainable agricultural production trends pose a need to change production technology processes with the application of techniques, and  tools that cause less environmental pollution and contribute to ensuring health safety in general. Precision agriculture can be defined as an agricultural production process that includes the application of information technology and various types of sensors, satellite positioning, and monitoring of farming machinery. Aerial remote sensing is regarded as one of the most crucial technologies for smart and precision agriculture. This mini-review aims to summarize the applications of drones in precision agriculture with special reference to crop monitoring and pest management. Drone equipped with modern capabilities like Artificial Intelligence integrated systems with multispectral cameras help the farmers to observe aerial images of crops in real time. Camera-equipped drones use advanced image data analysis tools to identify diseased or defective plants which assists the farmer in crop monitoring. Also, the fully automatic pesticide spraying system analyzes real-time data and is capable of spot spraying. The use of drone-borne sprayers in the field increases coverage, chemical effectiveness, and make spraying operations easier and faster. Each type of drone has its performance drawbacks, such as high operating and maintenance costs, limited flight range, time, and payload capacity, but with accelerating technology development and the systems integrated into drones, they offer a promising role in advancing precision agriculture.
Probing Acid Sulphate Soils for Sustainable Rice Production in Kuttanad: Challenges and Solutions
Authors: A K Rohith. , Joseph Biju , R Gladis.
Published: December 2024

Acid sulphate soils of Kuttanad region in Kerala belongs to the category of problem soils, where crop production can be achieved through extensive soil management. Existence of jarosites, Fe, Al and Mn causes severe acidity in soil, while saline water intrusion due to nearness of sea can add salinity concerns. In addition, these soils were carbon rich with the existence of profound organic matter content, but biased with nutrient status of soil. Hence rice (Oryza sativa L.) is difficult to grow in this soil. Apart from the conventional practice of liming, use of organic amendments including rice husk ash, biochar, green manures and more could manage the acidic nature of soil to an extent and impart consistent nutrition without deterioration. Use of newly introduced genetic tolerant varieties, adaption of phyto-mining techniques and other critical land amendment practices can efficiently manage these soils for rice cultivation. The purpose of this review is to comprehend the soil properties and management strategies of acid sulphate soils of Kuttanad in order to produce rice as well as support further researches.
Addressing Mental Health Access in Underserved West Africa: A Strategic Framework
Authors: Adebayo Adebusola J , Inyang Lovina Patrick
Published: December 2024

Aim: To address mental health crisis focusing on the applicable framework for strengthening access in underserved West African communities.
Problem Statement: The World Health Organizarion (WHO) states that approximately 450 million people have a mental disorder and about one-quarter of the population will be affected from mental ailment at some stages in their lifetime. Handling of crisis relating to mental health is underserved in some West African communities.
Significance of Study: The high rise in the number of mental health cases in some underserved communities in West Africa has called for designing a workable and applicable framework to ameliorate this situation.
Methodology: Previous literatures, journals, books, research write-ups and other related materials on the internet regarding to address mental health crisis focusing on the applicable framework for strengthening access in underserved West African communities were consulted.
Discussion: Strengthening health systems in some underserved communities in West Africa to advance mental health care delivery adopting the WHO framework and other beneficial indigenous methods is achievable. These merged methodologies can increase the quality and nature of mental health care delivery systems. They can also increase the existing mental health care services in order to make them to be more effective and efficient in meeting the requirements of the people. With a strengthened health system, the condition of mental health delivery across West Africa will be improved. There is an emergency quest for rigorous effort between the policy makers, government and international organizations to execute the recommendations stated herein for an accessible, better and affordable mental health services for the mental well-being of the public in advancing mental health services and care.
Conclusion: In conclusion, it is imperative to adopt and apply the elements of the framework stated in strengthening mental health services in some underserved West African   communities.