bluuebunny/crossref_metadata_2025 huggingface dataset:
Expression of Five Target Proteins Related to Human Cytomegalovirus Infection in Brain Metastases of Lung Cancer
Authors: Wu Jie , Zhao Haifeng , Yan Ke , Xie Xiangtong , Gu Donghua , Wang Weihua , Fei Xifeng , Zhu Wenyu , Wang Zhimin , Huang Qiang
Published: July 2021

Background: The links between brain metastases of lung cancer and human cytomegalovirus (HCMV) infection have been controversial for a long time. This study aims to explore the links between brain metastases of lung cancer and HCMV infection from the perspective of expression and detection of HCMV immediate early gene (IE), guanine nucleotide-binding protein 4 (GBP4), CXC chemokine receptor 4 (CXCR4), thyroid transcription factor 1 (TTF1) and epidermal growth factor receptor (EGFR) proteins. Methods: We collected brain metastases specimens and lung primary tumor specimens of a series of patients that have not undergone any treatment. Conventional hematoxylin and eosin staining and immunohistochemical staining of target molecules was performed. We used the ImageJ software to process the average optical density value of immune complexes and GraphPad Prism 8.0.1 to perform image analysis, and the SPSS 22.0 statistics package (t test) to analyze the expression differences of target molecules.Results: Based on five cases of brain metastases and two cases of lung primary tumors, a total of seven samples were investigated. Conventional pathology diagnosis reported four cases of brain metastases of lung adenocarcinoma and one case of brain metastases of mixed small cell lung cancer with adenocarcinoma. Among the 19 molecular immunopathological test samples, only GBP4, related to HCMV infection, and TTF1, related to metastases, were highly expressed in all seven samples. A comparison of the AOD values of the primary lung cancer to the AOD values of brain metastases, yielded statistically significant differences as follows: in Case No.1, GBP4 (p=0.016), EGRF (p<0.001); in Case No. 2, IE (p<0.001), CXCR4 (p=0.005), EGFR (p=0.023), TTF1 (p=0.004). Conclusions: Although TTF1 is known to be a kinesin for brain metastases of lung cancer cells and it is associated with poor survival prognosis, the role of GBP4, which is closely related to HCMV infection and a key protein of brain metastases of lung cancer, remains unknown. The findings provide new knowledge into the role of GBP4 and could provide clues for devising novel strategies for target molecular therapy research in brain metastases of lung cancer in the context of HCMV infection.
Use of Caenorhabditis Elegans and Zebrafish Embryo as an Alternative Model for Biocompatibility Assessment of Natural Latex Biocomposite
Authors: Miranda Matheus Carlos Romeiro , Borges Felipe Azevedo , Barros Natan Roberto , Marques Marina Paganine , Galeane Mariana Cristina , Singulani Junya , Guerra Nayrim Brizuela , Pegorin Giovana Sant'Ana , Mussagy Cassamo Ussemane , Almeida Ana Marisa Fusco , Giannini Maria José Soares Mendes , Herculano Rondinelli Donizetti
Published: July 2021

The number of animals killed used for research purposes has increased significantly in recent years. For this reason, several alternatives of animal models are widely used. In this study, two phases of calcium phosphates synthesized by the sol-gel method were added by precipitation to the surface of the natural rubber latex membranes for bone applications. Membranes cytotoxicity and toxicity was evaluated by in vitro and in vivo methods. Hemolysis levels were less than 3%, which indicates that there was no significant hemolytic activity. It was demonstrated that latex presents enzymes that can dissociate osteoblasts MC3T3, so it was necessary to eliminate these enzymes to obtain a good adhesion and cellular proliferation without morphological alterations. The in vivo toxicity test with Caenorhabditis elegans worms did not show evidence of toxicity with a sample of hydroxyapatite incubated for 5 days, exhibiting the lowest survival rate of the worms. In the Zebrafish embryotoxicity assay, 60% of embryos survived and there was no evidence of embryos with malformation or developmental delay. In summary, alternative animal models, which are not commonly used to assess biocompatibility, have provided reliable in vivo results that allow suggesting the use of these membranes in the bone biomedical.
Silencing miR-199a-3p, Which Targets Integrin Β8 Prevents Steroid-induced Avascular Necrosis of the Femoral Head by Regulating Osteogenesis and Adipogenesis
Authors: Yang Wu , Yang Yunfei , Guo Minkang , Zhu Weiwen , Qian Husun , Lian Chengjie , Bai Haobo , Wang Hongwei , Chen Tingmei , zhang jian
Published: July 2021

BackgroundThe main pathogenesis of steroid-induced avascular necrosis of the femoral head (SANFH) is closely connected with osteogenesis and adipogenesis. MicroRNAs have been proved to play prominent roles in the initiation and progression of SANFH. The present study investigated the effects of silencing miR-199a-3p on the prevention and early treatment of SANFH. MethodsRT-PCR was used to detect the expression of miR-199a-3p. Western blotting was used to detect protein expression. Alkaline phosphatase (ALP) activity, alizarin red S staining, and oil red O staining were used to study the effect of miR-199a-3p on the osteogenic and adipogenic differentiation of rat bone marrow-derived mesenchymal stem cells (rBMSCs) and MC3T3-E1 cells. A dual-luciferase reporter assay was used to confirm the target relation of miR-199a-3p and integrin β8 (ITGB8). Animal study was used to explore the effect of silencing miR-199a-3p in vivo.ResultsMiR-199a-3p expression was upregulated in necrotic bone tissues and rBMSCs and MC3T3-E1 cells treated with 20 UM dexamethasone. Western blotting and a dual luciferase assay were employed to verify that miR-199a-3p directly targets ITGB8. Silencing of miR-199a-3p also promoted osteogenesis and inhibited adipogenesis of rBMSCs and MC3T3-E1 cells in the presence or absence of glucocorticoids. In addition, the silence of miR-199A-3p prevent SANFH by promoting osteogenesis in rats.ConclusionThe upregulation of miR-199a-3p induced by GCs could reciprocally regulate the adipo-osteogenic differentiation of rBMSCs and MC3T3-E1 cells by targeting ITGB8. The miR-199a-3p-ITGB8-FAK-Erk1/2-RUNX2 axis is a potential signaling mechanism, and inhibition of miR-199a-3p expression could promote osteogenesis and inhibit adipogenesis to alleviate the occurrence of SANFH.
Numerical Treatment for the Second Law Analysis in Hydromagnetic Peristaltic Nanomaterial Rheology: Endoscopy Applications
Authors: Awais Muhammad , Shoaib Muhammad , Raja Muhammad Asif Zahoor , Arif Saba , Malik Muhammad Yousaf , Nisar Kottakkaran Sooppy
Published: July 2021

In current study, analysis is presented for peristaltic motion of applied magnetic field and entropy generation within couple stress (Cu/H2O) nanofluid through an endoscope. An endoscope contains two coaxial cylindrical tubes in which the internal tube is nonflexible while the external tube has sinusoidal wave passing through the boundary. Influences of mixed convection along with applied magnetic field are encountered as well. Formulated governing model is fabricated introducing long wavelength and creeping Stokesian flow approximation which are then analyzed numerically by utilizing Adams Bashforth method. For a physical insight, results are demonstrated to examine the behaviors of flow profiles and entropy generation number for emerging flow parameters with the help of graphs, bar-charts and tables.
Plant Based High Energy Mash Diets Supplemented With Nahco3, L-arginine+ Vitamin-c and Vegetable Oils Are Effective Against Tachycardia and Polycythemia in Broiler Chicken
Authors: Hossain Md Emran , Akter Nasima
Published: July 2021

The study aimed to investigate if plant based high energy mash diets supplemented with NaHCO3, L-arginine + vitamin-C and vegetable oils were effective against tachycardia and polycythemia in the commercial broiler chicken. Total 256Ross-308 day old male broiler chicks were randomly distributed into eight dietary treatment groups in a three way 23 factorial arrangements (Three factors, i.e., NaHCO3, L-arginine + vitamin-C and vegetable oil each with two levels, e.g., 0 and 0.1% for NaHCO3 and L-arginine + vitamin-C; 3 and 4% of vegetable oil supplemented with basal diet). Iso-caloric and iso-nitrogenous diets were formulated and supplied ad libitum. The average daily feed intake (ADFI), average daily gain (ADG), feed efficiency (FE), carcass characteristics, cardio-pulmonary morphometry, total protein (TP), hemoglobin (Hb), triiodothyronine (T3), incidence of tachycardia and polycythemia were examined up to 35 d. Supplementation of NaHCO3decreased (p<0.001) the ADFI at 1-14 d, 15-35 d, 1-35 d, improved (p<0.01) the FE at 1-14 d and increased (p<0.05) the serum TP. Dietary L-arginine + vitamin-C decreased (p<0.01) the heart rate without affecting the performance parameters, carcass characteristics and hemato-biochemical indices. Supplementation of vegetable oil decreased (p<0.01) the ADFI at 1-14d, 15-35 d, 1-35 d, increased (p<0.01) the ADG at 1-14d, improved (p<0.001) the FE at 1-14 d and increased (p<0.05) the heart rate, Hb and PCV. Further, NaHCO3, L-arginine + vitamin-C and vegetable oil synergistically interacted to decrease the left and right ventricular weight, RV:TV and increased the T3 without affecting overall performance, carcass characteristics and hemato-biochemical indices. It was concluded that, plant based high energy mash diets are not susceptible to tachycardia and polycythemia. Addition of NaHCO3, L-arginine + vitamin-C ameliorate the propensity of tachycardia and polycythemia without deteriorating performance, carcass characteristics and hemato-biochemical indices of the commercial broiler birds in a dose dependent manner.
Geometric Morphometrics Captures Variations in Wing Development of Black Soldier Flies
Authors: Gyimah Obediah , Combey Rofela , Ewusie Ebenezer Ato , Badu Isaac , Yeboah Simon , Apaatah Francis , Nagetey Amuetey , Quandahor Peter
Published: July 2021

The black soldier fly is considered an important insect due to its ability to convert organic wast into high quality organic fertilizer. Studies have shown that food quality at the larvae stage contributes greatly to their development. In this study, we applied geometric morphometric measurements to access the variations in the black soldier fly fed on different food substrates as captured in the wings. Eggs of black soldier fly were collected from the field and cultured on different food substrates such as; restaurant waste, fruit waste, wheat brand and layer meal until maturity. The right fore wing of 140 individuals of black were used for the experiment. The results showed a significant difference between the shape of landmarks within each food substrate group. Landmark 3, 7 and 9, corresponding to end of first radial vein R1, intersession between medio-cubital vein and cubito-anal vein (m-cu and CuA), and intersission between cubito Anal vein and Anal vein (CuA + Cup) contributed most to the variation between the different food substrates. Partial least square showed a strong association between food substrate and wing development. Therefore, the variations in wing development could be due to the impact of nutritional compositions quality of the different food substrates.
Assessment of α-cypermethrin Pour-on Application and Diminazene Aceturate for the Treatment of Trypanosome-related Diseases Caused by Tsetse Flies in Cattle in Mô (Togo)
Authors: Boma Soudah , Talaki Essodina , N'Féidé Toï , Dao Balabadi , Lombo Yao , Somda Martin Bienvenu , Salou Wendemanegdé Ernest
Published: July 2021

BackgroundThe effects of tsetse-transmitted trypanosomosis control in high tsetse challenge and trypanocidal drug resistance settings remain poorly understood in Togo, owing to the poor data underlying the current disease impact. This study was implemented in the framework of the PDRI-Mô project which is an African animal trypanosomosis control project using trypanocides and insecticides on cattle. This project, planned by the agricultural ministry, focused on all the sedentary cattle breeds in the 1000 km² area of the prefecture of Mô. Until 2013, the locality remained unconnected to outside areas, with long-term limited access to quality medicines, veterinary services, animal husbandry and new AAT control technologies. Methods From March 2014 to November 2017, a database of zoo-sanitary surveys integrating the evolution of the incidence of the disease and the coverage of interventions made it possible to quantify the apparent effect attributable to control effort in herds. The strategy involved an initial phase with cross-sectional entomological and parasitological surveys, including a rapid trypanocidal drug sensitivity testing. Treatment efficacy was assessed using parasitological status post-treatment of trypanosome-positive animals in each village, randomly assigned to three groups, one treated with 0.5 mg/kg b.w. Isometamidium chloride, the second with 3.5 mg/kg b.w. Diminazene diaceturate and the third with distillated water as control. Using parasitological status of blood sample collected on day 0, day 14 and day 28 post-treatment as the outcome result, trypanosome phenotype resistance of drugs treatment was determined if relapse occur. Then, three times a year, 20% of the herd received α-cypermethrin pour-on, and parasitaemic cattle with poor health were individually given diminazene aceturate at 7 mg/kg of body weight (b.w.).ResultsThe tsetse density in the area decreased significantly (P-value ˂ 0.001) from 1.78 ± 0.37 in March 2014 prior to the α-cypermethrin application to 0.48 ± 0.07 in February 2017. Prior to the trypanocidal treatment, relapse of trypanosome infections in the cattle was approximately 12.5% for diminazene at 3.5 mg/kg of b.w., 35% for isometamidium at 0.5 mg/kg of b.w. and null for diminazeen at 7 mg/kg of b.w. Target deployment led to the largest reduction in disease incidence from 28.1% in 2014 to 7.8% in 2017, an improvement in haematocrit from 24.27±4.9% to 27.5±4.6% and a reduction in calf mortality from 15.9±11% to 5.9%.ConclusionsImproving the access to these interventions for different types of livestock and maintaining their effectiveness in the face of high tsetse challenges should be the primary focus of control strategies in areas of Togo.
Evaluating factors that influenced the successful implementation of an evidence-based neonatal care intervention in Chinese hospitals using the PARIHS framework
Authors: Yue Jieya , Liu Jun , Zhao Yingxi , Williams Sarah , Zhang Bo , Zhang Lin , Zhang Qiannan , Liu Xin , Wall Stephen , Zhao Gengli
Published: July 2021

Background
Evidence based interventions (EBIs) can improve patient care and outcomes. Understanding the process for successfully introducing and implementing EBIs can inform effective roll-out and scale up. The Promoting Action on Research Implementation in Health Services (PARIHS) framework can be used to evaluate and guide the introduction and implementation of EBIs. To gain an understanding of the utility of the PARIHS framework in China and investigate how important each of its constructs (evidence, context and facilitation) and sub-elements are perceived to be to successful implementation of EBIs in a Chinese setting, we used the framework to assess the implementation of an evidence-based neonatal intervention (kangaroo mother care, KMC) recently introduced in selected Chinese hospitals.
Method
We conducted clinical observations and semi-structured interviews with 10 physicians and 18 nurses in five tertiary hospitals implementing KMC. Interview questions were organized around issues including knowledge and beliefs, resources, culture, implementation readiness and climate. We used directed content analysis to analyze the interview transcript, amending the PARIHS framework to incorporate emerging sub-themes. We also rated the constructs and sub-elements on a continuum from “low (weak)”, “moderate” or “high (strong)” highlighting the ones considered most influential for hospital level implementation by study participants.
Results
Our finding suggest that clinical experience, culture, leadership, evaluation, and facilitation are highly influential sub-elements for EBI implementation in China. External evidence had a moderate impact, especially in the initial awareness raising stages of implementation and resources were also considered to be of moderate importance, although this may change as implementation progresses. Patient experience was not seen as a driver for implementation at hospital level.
Conclusion
The PHARIS framework can be a useful tool for planning and evaluating EBI implementation in China. However, it’s sub-elements should be assessed and adapted to the implementation setting.
Evaluation of saliva molecular point of care for detection of SARS-CoV-2 in ambulatory care
Authors: LeGoff Jérôme , Kernéis Solen , Elie Caroline , Delarue Séverine Mercier , Gastli Nabil , Choupeaux Laure , Fourgeaud Jacques , Alby Marie-Laure , Quentin Pierre , Pavie Juliette , Brazille Patricia , Néré Marie Laure , Minier Marine , Gabassi Audrey , Leroy Chrystel , Parfait Béatrice , Tréluyer Jean-Marc , Delaugerre Constance
Published: July 2021

Background
Rapid identification of SARS-Cov-2 infected individuals is a cornerstone for the control of virus spread. The sensitivity of SARS-CoV-2 RNA detection by RT-PCR is similar in saliva and nasopharyngeal swab. Rapid molecular point-of-care tests in saliva could facilitate, broaden and speed up the diagnosis.
Methods
We conducted a prospective study in two community COVID-19 screening centers to evaluate the performances of a CE-marked RT-LAMP assay (EasyCoV™) designed for the detection of SARS-CoV2 RNA from fresh saliva samples, compared to nasopharyngeal RT-PCR, to saliva RT-PCR and to nasopharyngeal antigen testing.
Results
Overall, 117 of the 1718 participants (7%) were tested positive with nasopharyngeal RT-PCR. Compared to nasopharyngeal RT-PCR, the sensitivity and specificity of the RT-LAMP assay in saliva were 34% and 97% respectively. The Ct values of nasopharyngeal RT-PCR were significantly lower in the 40 true positive subjects with saliva RT-LAMP (Ct 25.9) than in the 48 false negative subjects with saliva RT-LAMP (Ct 28.4) (p = 0.028). Considering six alternate criteria for reference test, including saliva RT-PCR and nasopharyngeal antigen, the sensitivity of saliva RT-LAMP ranged between 27 and 44%.
Conclusion
The detection of SARS-CoV-2 from crude saliva samples with a RT-LAMP assay had a lower sensitivity than nasopharyngeal RT-PCR, saliva RT-PCR and nasopharyngeal antigen testing.
Registration number
: NCT04578509
Polymeric nanoparticles improved Curcumin brain delivery and its therapeutic efficacy against intracerebral hemorrhage
Authors: Yang Cong , Han Meng-Meng , Li Ruo-Yu , Yang Yu-Na , Zhou Li-Gui , Duan Li-Ning , Su Shi-Yu , Li Min , Wang Qi , Chen Tong-Kai , Mo Yousheng
Published: July 2021

Background: Intracerebral hemorrhage (ICH) is a severe type of stroke. Ferroptosis is a new form of regulated cell death, which plays an indispensable role in the pathological process of ICH. Curcumin (Cur), a widespread phenolic compound, is derived from the rhizome of Curcuma longa. It could attenuate hematoma volume and neurological injury in ICH. Nevertheless, its poor solubility in water, low oral bioavailability and difficulty in transporting across physiological barriers led to poor efficacy. Polymer nanoparticles (NPs) are widely used drug delivery matrix material with good biocompatibility, which are reported to improve the bioavailability and pharmacokinetic profiles of drugs. In this study, we utilized NPs to encapsulate Cur and analyzed the effect of Cur-NPs on Cur brain delivery and its therapeutic efficacy against ICH. Results: The spherical Cur-NPs had a particle size 127.31±2.73 nm, a PDI of 0.21±0.01 and a zeta potential of -0.25±0.02 mV. Cur-NPs could draw into Madin-Darby canine kidney (MDCK) cells through a number of nonspecific endocytosis mechanisms, mainly mediated via clathrin and plasma membrane microcapsules. Moreover, Cur-NPs tended to accumulate in the endoplasmic reticulum and lysosome. In a zebrafish model, Cur-NPs could transport across physiological barriers. In a C57BL/6 mice model, we found that Cur-NPs had more desirable improvements in Cur accumulation within the plasma and brain. Importantly, in an ICH mouse model, we confirmed that Cur-NPs were an effective treatment for ICH. Finally, Cur-NPs effectively inhibited ferroptosis caused by erastin in HT22 mouse hippocampal cells. Conclusion: Cur-NPs represent a potentially effective strategy to enhance Cur brain delivery and therapeutic efficacy in the treatment of ICH.
Long Term Effects of Surgical And Transcatheter Aortic Valve Replacement On FFRCT In Patients With Severe Aortic Valve Stenosis.
Authors: Michiels Vincent , Andreini Daniele , Conte Edoardo , Tanaka Kaoru , Belsack Dries , Nijs Jan , Loo Ines Van , Argacha Jean Francois , Vandeloo Bert , Roosens Bram , Vandenbussche Karen , Cosyns Bernard
Published: July 2021

Background: the long-term variations of fractional flow reserve derived from coronary computed tomography (FFR CT ) after surgical (SAVR) or transcatheter (TAVR) aortic valve replacement in patients with severe aortic valve stenosis (AS) have not been investigated. Methods and Results: a total of 25 patients with isolated, severe AS underwent coronary computed tomography with 3-vessel FFR CT analysis (Heartflow Inc. - Redwood City, California, USA) and measurement of total coronary volume (V), left ventricular mass (M) and their ratio (V/M) before and 6 months after SAVR or TAVR. A significant increase in V/M due to a decrease in left ventricular mass 6 months after intervention was observed, whereas total coronary volume did not change (coronary volume pre: 2924,5 ± 867,9 mm 3 , coronary volume post: 2844,2 ± 792,8 mm 3 , P =0.158; LV mass pre: 151.7 ± 40.7 g, LV mass post: 127.3 ± 34.7 g, P <0.001; V/M pre: 19.5 ± 4.1 mm 3 /g, V/M post: 22.7 ± 4.28 mm 3 /g, P =0.002). FFR CT (expressed as area under the virtual pullback curve) remained constant. Conclusion: this proof-of-concept study showed that FFR CT was not subject to the confounding effect of left ventricular mass regression after SAVR or TAVR. Despite significant left ventricular remodeling at 6 months after AS treatment, FFR CT values remained constant. This means FFR CT can probably be used as a reliable test in AS patients but further studies are needed comparing the performance of the different invasive and non-invasive coronary physiological indices in this patient cohort.
An Improved Cutting Force Model in Micro-milling Considering the Comprehensive Effect of Tool Runout, Size Effect and Tool Wear
Authors: Liu Tongshun , Liu Yayun , Zhang Kedong
Published: July 2021

Tool runout, cutting edge radius-size effect and tool wear have significant impacts on the cutting force of micro-milling. In order to predict the micro-milling force and the machining performance related to the cutting force, it is necessary to establish a cutting force model including tool runout, cutting edge radius and tool wear. In this study, an instantaneous uncut thickness (IUCT) model considering tool runout, a nonlinear shear/ploughing coefficient model including cutting-edge radius and a friction force coefficient model embedded with flank wear width, are constructed respectively. By integrating the IUCT, the nonlinear shear/ploughing coefficient and the friction force coefficient, a comprehensive micromilling force model including the tool runout, size effect and tool wear is derived. Experiment results show that the proposed comprehensive model is efficient to predict the micro milling force.
Effect of IL6 -174 G/C Gene Polymorphism on Response to Interleukin-6 Blocking Therapy in Systemic Juvenile Idiopathic Arthritis.
Authors: nada doaa waseem , Gaber Rasha Ahmed , Salem Mohamed Labib , Allam Abdallah El Sayed , Ashkar Doaa Shawky Al
Published: July 2021

Objective: The main objective of this study is to analyze and evaluate the association of IL6-174 G/C gene polymorphisms with response to interleukin-6 blockade in Egyptian patients with systemic juvenile idiopathic arthritis, and to assess the effect of other factors on treatment response as well as long-term efficacy of treatment with Tocilizumab. Methods: Sixty systemic JIA patients (37 males and 23 females with median age at onset 5.2 years) who received IL-6 blockade (Tocilizumab) were recruited. The overall response to treatment with IL-6 blockade was assessed according to: 1) Clinical response, 2) switch (or no switch) to another biological DMARD therapy following IL-6 blockade, 3) achievement of clinically inactive disease within 6 months of IL-6 blockade, 4) improvement in disease activity measured using the modified JADAS-10, and 5) achievement of a glucocorticoid-free state. In addition, basic demographic, laboratory data, characteristics of the disease course and IL6 polymorphisms were assessed.Results: Three IL6 -174 genotypes, including, GG, GC, and CC were found with higher frequencies of GC genotype. These genotypes had non-significant association with the response of sJIA patients to IL-6 blockade in this cohort study. Moreover, a longer time frame from disease onset to diagnosis was associated with poorer long-term treatment response. Conclusion. No significant impact of IL6 -174 G/C gene polymorphisms on treatment response to IL6 blockade therapy in sJIA Egyptian patients, providing evidence of a “window of opportunity” for improved long-term treatment response with shorter time from the disease onset to diagnosis.
The morphology of large-scale debris avalanche deposit in Cianjur plains, West Java, Indonesia
Authors: Setiawan A. , Syafri I. , Yuningsih E.T. , Sudradjat A. , Burhanudinnur M.
Published: July 2021

The large-scale debris avalanche deposit (DAD) process are quite rarely occurring but the impact is catastrophic. Large-scale flank collapse from ancestral Gede volcano resulted in the deposition of debris avalanche deposit that manifested as prominent hummocky hill landform covering 192 km2 area in Cianjur plains, West Java, Indonesia. Although the deposit covers large areas and showing unique volcanic landscape morphology, the study on the debris avalanche deposit is limited. Here we show the result of field reconnaissance, satellite photo and digital elevation model analysis to understand the morphology of large-scale debris avalanche deposit including distribution and morphological characteristics. The interpreted thickness of the deposit ranging from 200-500m, although the hummocky hill with well-rounded texture is only 50–100 m height due to intense erosion in the tropical region with the remaining portion of the megaclast blocks buried. The distribution of hummocky hills indicate that the flow constrained by pre-existing basin configuration. The debris avalanche deposit showing fan-like morphology that characterized block facies located near the fan mouth, while the matrix facies with matrix-supported smaller blocks in the distal part. The mouth of debris avalanche deposit located just south of Cianjur township with the highest concentration of megaclast block as block facies that interpreted as the main depositional axis. The block facies apparently stopped by lineament of SW-NE oriented Cimandiri valley to the southeast and NNE-SSW oriented Cisokan river lineament to the east which interpreted as buried normal fault that considered as the barrier to confine flow of block facies deposition.
Assessing Clinical Outcomes Post Modified Laparoscopic Gastrostomy in Children: a Case Control Study
Authors: Naji Hussein , Gheewale Aafia Mohammed Farooq , Safi Ebtesam
Published: July 2021

BackgroundGastrostomy has become a common surgical procedure within the pediatric population with feeding difficulties and nutritional issues. In the aims of improving clinical outcomes, this research targets to compare the rate of complications of two different laparoscopic techniques of a gastrostomy button placement in a pediatric population: A combination of modified U-stitches and seldinger technique laparoscopic gastrostomy (MLG) versus the standard laparoscopic gastrostomy (LG).MethodsEighty-nine children were recruited for this retrospective case control study that assesses the surgical outcomes of a novel MLG, being the cases to the standard LG in children which are the controls. The main outcome measure is the rate of postoperative complications encompassing dislodgement of gastrostomy button, leak around button, local infection, and development of granulation tissue post-surgery which is compared between the two population groups.ResultsThe p-value of the study was shown to be 0.03 proving a statistical significance between the complication rates. ConclusionAs a result, the modified U-stitches laparoscopic gastrostomy has a lower rate of complications in comparison to the standard laparoscopic gastrostomy making it a better technique for gastrostomy placement in children.
Associations of Novel Indices of Adiposity with Incident Heart Failure
Authors: Suthahar Navin , Meems Laura , Withaar Coenraad , Gorter Thomas , Kieneker Lyanne , Gansevoort Ron , Bakker Stephan , Veldhuisen Dirk van , de Boer Rudolf
Published: July 2021

Objective: To examine associations of newly-developed adiposity indices with incident heart failure (HF).Participants and Methods: The current study included 8493 adults from the PREVEND observational cohort (mean age: 49.8 years; 50% women). Exposures included novel adiposity indices i.e., relative fat mass (RFM), body-roundness index (BRI), weight-adjusted-waist index and body-shape index (BSI), as well as established adiposity indices i.e., body-mass index (BMI), waist circumference, and waist-hip ratio (WHR). Main outcome was development of incident HF.Results: The prevalence of overweight (BMI: 25-30kg/m2) and obesity (BMI≥30kg/m2) were 41% and 17% respectively. During 11.3±3.1 years of follow-up, 372 HF events were recorded, resulting in an overall HF incidence of 3.88 per 1000 person-years. All novel adiposity indices, except BSI, were significantly associated with incident HF (P<0.001). BMI, WC and WHR were also significantly associated with incident HF (P<0.001). Sex did not modify the association of any adiposity index with incident HF (Pint>0.1). Amongst adiposity indices, RFM displayed the strongest effect sizes (HR:1.67, 95%CI, 1.37-2.03). This trend persisted across multiple age categories, BMI categories and also among HF subtypes. All obesity measures, except BSI, improved the fit of the clinical HF model. Strongest improvement was observed after adding BRI and RFM (reduction in Akaike information criteria: 26.5 and 24.4 respectively).Conclusions: Relative fat mass is strongly associated with incident HF in the community. Future studies should examine the value of novel adiposity indices in HF risk estimation.
Meloidogyne incognita management by nematicides in tomato production
Authors: Grabau Zane J. , Liu Chang , Sandoval-Ruiz Rebeca
Published: July 2021

Meloidogyne incognita (southern root-knot nematode, SRKN) is a major pest in tomato (Solanum lycopersicum) production in the Southeastern United States. Management has relied on fumigant and carbamate non-fumigant nematicides. New non-fumigant nematicides, such as fluopyram, are available and field evaluation of new nematicides is needed. The objectives of this research were to assess the efficacy of new (fluopyram) and established (oxamyl) non-fumigant nematicides as well as fumigation (1,3-dichloropropene) for (1) SRKN management, and (2) impacts on total soil abundances of non-target, free-living nematodes in field tests in Florida. Fumigation with 1,3-D consistently managed SRKN and, in two of three trials, increased yield relative to untreated. Oxamyl and fluopyram also had efficacy in managing SRKN, but were inconsistent from year to year. Oxamyl provided better root galling control than fluopyram in one of two trials, but otherwise those nematicides provided similar SRKN management and yield response. Supplementing 1,3-D fumigation with fluopyram did not improve SRKN management or yield relative to fumigation alone. Fumigation consistently reduced free-living nematode abundances relative to untreated. Oxamyl and fluopyram were more inconsistent, but always reduced total free-living nematode abundances when effective against SRKN. In summary, while non-fumigant nematicides provided some management of SRKN, fumigation continued to be the most consistent option. All nematicides had deleterious effects on free-living nematodes.
Reproduction of Meloidogyne arenaria race 2 on flue-cured tobacco with putative resistance derived from Nicotiana repanda
Authors: Adamo Noah , Johnson Charles S. , Reed T. David , Eisenback Jonathan D.
Published: July 2021

Chemical controls for root-knot nematodes are increasingly restricted due to environmental and human health concerns. Host resistance to these nematodes is key to flue-cured tobacco production in Virginia. Resistance to Meloidogyne incognita races 1 and 3, and race 1 of M. arenaria is imparted by the gene Rk1, which is widely available in commercial flue-cured tobacco. Rk2 imparts increased resistance to M. javanica when stacked with Rk1 and is becoming commercially available. The efficacy of Rk2 against M. arenaria race 2, which is increasingly prevalent in Virginia, is unclear. Greenhouse trials were conducted in 2017 to determine how potential resistance derived from N. repanda compares to the root-knot nematode resistance afforded by Rk1 and Rk2. Trials were arranged in a completely randomized block design and included an entry with traits derived from N. repanda, a susceptible entry and entries possessing Rk1 and/or Rk2. Data collected after 60 days included percent root galling, egg mass counts, and egg counts. Root galling and reproduction were significantly lower on the entry possessing traits derived from N. repanda relative to other entries, suggesting that the N. repanda species may hold a novel source of root-knot nematode resistance for commercial flue-cured tobacco cultivars.
Sociocultural Tradition in Economic Development (communicative aspect)
Authors: Grigoryan T. R.
Published: July 2021

The article is devoted to the topical problem of interaction between culture and economy. The sociology of culture studies this issue in order to identify the factor role of culture and economy in the mechanisms of sociogenesis in modern conditions. The author examines the role and place of socio-cultural traditions, norms and values in the economic system of society and the economic activity of modern Russian society; within the study the attention is drawn to what determines reality and forms a space for communication of subjects of social relations. In this regard, the work defines the socio-cultural tradition as the basis of communication, interaction between culture and economy. The author analyzes the development of views and ideas on the relationship between culture and economy in the works of foreign and domestic researchers, and also considers tradition as the basis that forms the economic model of human behavior. Based on research the author considers the sociocultural tradition the core that determines, explains and predicts human behavior in economic life.
The Concept of Creating Visual Content for Promotion in the Media Space (on the example of cultural and event tourism)
Authors: Sosnovskaya K.-M. A.
Published: July 2021

A competitive, attractive and even unique project or product, without its wide representation in the information space, will not receive proper implementation and response. Without effective promotion in the mass media, and this applies to almost any sphere from the economy to culture, the creation process will be incomplete and incomplete. Creating a visual production requires a deep understanding of various communication processes: the laws of communication, the basics of audience perception, cognitive principles, as well as the basics of drama and Public Relations. The article is based on the understanding of theoretical knowledge and scientific sources on this topic, as well as the practical long-term experience of the author of the study in creating visual works of different genres, styles and directions. The material of this study is given on the example of the sphere of cultural and event tourism, however, the scope of application is much wider. This concept, due to its universality, can be used for the preparation of visual works and their further promotion in the media space in various fields of application, e.g. economy, society, culture, ecology, besides it provides a methodological component for teaching students of specialized areas.
Volunteering Activity in the Museums of Conscience: a combination of communication theory and cultural approaches
Authors: Lemeshevskaya E. S.
Published: July 2021

The paper represents a brief history of the emergence and development of the concept of “museum of conscience”, as well as the essence and examples of volunteering in museums of conscience. The process of the formation of museums of conscience is shown through a retrospective of the events of the 20th – early 21st centuries and the resulting cultural trends, mindsets: the struggle for human rights, equality, independence, discussions about the culture of memory, trauma, the significance of the experience of an individual for history. Examples of volunteer activities in museums of conscience both in Russia and abroad are given. In the article, the author examines the possibility of using a combination of communication theory and cultural approaches to consider the link Volunteering – Museum of Conscience – Culture.
Public Dialogue in the Socio-Cultural Environment and its Management Perspectives in the Communication Theory of W. Barnett Pearce and Vernon E. Cronen (continuation)
Authors: Andriyanova T. V.
Published: July 2021

Management perspectives of the concept of «public dialogue» are revealed in the article on the basis of secondary data of the project of Сupertino (Сalifornia, USA), carried out in the 90s of the twentieth century by a research group led by W.B. Рeirce and V.E. Кronen. The view of the theory of coordinated control of meaning as the conceptual basis of this project allowed the authors to focus on the co-evolution of its methodological foundations and empirical potential, which was expressed in the development of criteria for evaluating any practical theory and improving its conceptual apparatus. The six key principles identified by the authors as SMM Grammar: coordination, forms of communication, event (case), forces of logic, position of the intermediary personality, and contextual reconstruction allow us to take a broader look at the possibilities of the modern field of scientific discourse and the communicative process as a whole. A long-term social dialogue allows us to harmonize the interests of different social groups not by unilateral managerial influence, but by allowing all stakeholders to engage in a constructive dialogue. The main empirical method here is contextual reconstruction of events (focus groups, group discussions, etc.) with the involvement of an рerson-рosition of the facilitator (moderator).
Discourse analysis of the concept of the Community of the Common Destiny and its reflexive component
Authors: Pomozova N. B.
Published: July 2021

The author attempts to comprehend, from the standpoint of sociological discourse analysis, the main modern foreign policy concept of China – the Community of the Common Destiny. In the context of the multi-vector confrontation between the United States and China, the main struggle is for the loyalty of Europeans, namely, citizens of the most economically developed countries of the European Union. In this context, Beijing views discursive power as one of the main tools, without the development and application of which it is impossible to naturally take its rightful place in the international arena. After analyzing Western philosophical theories, including those that were used to create the European Union (Bauer, Renan), the Chinese leadership put forward a global concept that was the result of corresponding sociological reflection. According to Habermas, discourse involves the involvement of the Other in the discussion and is aimed at achieving mutual understanding and agreement. Discourse analysis of the Community of the Common Destiny (based on the material of some speeches of the PRC Chairman Xi Jinping) confirms the following hypothesis: despite its global character and corresponding ambitions, it is formulated in such a way as to be understandable and acceptable, primarily for Europeans.
Implementation of the climate therapy methods in medical pedagogy: retrospective aspect
Authors:   Omsk Humanitarian Academy, Shmachilina-Tsibenko S.V.
Published: July 2021

In the context of the formation and development of methods of therapeutic pedagogy, methods of climate therapy with their integrative essence are assigned a role related not only to treatment, but also to prevention, recovery, hardening of the child's body, rehabilitation, recreational activities, education of a sense of beauty, the development of resourcefulness, intelligence, honesty. A significant role in the origin and functioning of these methods is assigned to the medical and recreational institutions of the Republic of Crimea (Tavrichesky province), each of which, in its essence, was a unique creation of the early twentieth century. The empirical basis of the article is the analysis of archival documents of the Republic of Crimea (Tavrichesky province) and modern research. The purpose of the article is to reveal the specifics of the use of climate therapy methods in the context of therapeutic pedagogy in the conditions of children's health and medical institutions of the southern region of Russia at the beginning of the XX century. Research result: 1.The specifics of the use of climate therapy methods in the children's hospital of doctors L. Finkelstein and A. Yakubovsky, the resort of Dr. V. Lyapidus, climate colonies of the Southern coast of Crimea, playgrounds of Kerch and Simferopol are revealed. 2.The integrative nature of these methods, their non-drug orientation in the conditions of children's health-improving institutions in the southern region of Russia, their relationship with other educational methods of pedagogy and therapeutic pedagogy are shown. 3. The anthropological and humanistic orientation of the activity of doctors of that time who were able to productively integrate the therapeutic and educational process in a children's medical and health-improving institution is shown
The influence of physical culture on the quality of life.
Authors:   The Department of Physical Training and Sport of the Armed forces of the Russian Federation (Moscow), Zykov A.V. , Chudaykin A.M. ,   Military Academy of Logistics (Penza).
Published: July 2021

The aim of the article is to define the role physical culture plays in influencing the quality of life of a modern person and society in general. The phenomenon “quality of life” is analyzed as a combination of the three spheres: physiological, emotional, and spiritual ones. The potential of physical culture in each sphere is revealed. It is shown that the health-improving effect of physical culture is due to an increase in physical activity of a person, while its deficiency provokes a violation of the physiological functions of the body. It is noted that the most effective ways to maintain physical health are feasible physical activity and tempering. A wide range of the emotions experienced, and their intensity determines the influence of physical culture on the physiological sphere of life. The most significant emotional states in the formative relation are mentioned: excitement, enthusiasm, passion, sports anger, rivalry, aggressiveness, pride. The influence of physical culture on the spiritual sphere of human life is due to its value potential. The idea is expressed that the main way for physical culture to influence the spiritual sphere is to develop a value attitude to physical culture as a phenomenon and occupation. It is also noted that physical culture is one of the most powerful means of socialization of people of any age. The conclusion is drawn that to provide a complex impact on the quality of life physical culture is to become a way of life for the modern person. It will improve health indicators, will form active life position, and it will provide self-realization of a person.
Pemeriksaan Cemaran Kapang Pada Udara Dan Pakaian Santri Di Salah Satu Pondok Pesantren Surabaya Timur
Authors: Arimurti Anindita Riesti Retno , Azizah Fitrotin
Published: July 2021

Dormitory is a place for student who built in various small scales to a very large scale. Of the many dormitory residents with bad space such as lack of ventilation and incoming sunlight, the large number of scattered students' clothes causes the room to become damp. The presence of air mold is caused by the lack of ventilation as well as the humidity of the room environment in the dormitory which can cause several diseases, one of which is ARI. The purpose of this study was to determine whether or not there is mold contamination on air in the room and clothes of the students at one of the Islamic boarding schools in East Surabaya. This type of research is descriptive. The sample used is air in several dormitory rooms at one of the Islamic boarding schools in East Surabaya. This research method uses the isolation technique of Sabauraud Dextose Agar (SDA) media which is partially opened and then placed in several rooms in this Islamic boarding school. Second, 30 samples of clothes were taken randomly from students from different disciplines and then scratched on SDA media. In the results of macroscopic observations, of the 30 sampled rooms. Microscopic colonies of cotton taken from the media showed positive results for hyphae, mycellium, spores, and conidiospores. The results obtained were positive there were Aspergillus sp.  with the percentage was 100% while the results of the students' clothing swabs, from 30 clothing samples found 80% positive for mold contamination.
Investigating the feasibility of removing the rapid mixing unit in conventional surface water treatment and its effect on turbidity removal
Authors: Hessam Abolfazl , Mehdinejad Mohammad Hadi
Published: July 2021

Coagulation and flocculation processes play a major role in surface water treatment. The aim of this study was to eliminate the rapid mixing unit in the water treatment plant. This experimental study was conducted on turbid water. Turbid water was synthesized by kaolin powder. The conventional jar test method was used. The flocculation and sedimentation processes were performed on the turbid water without a rapid mixing unit for getting the new optimal condition. When the PACl coagulant was used alone and in conjunction with chitosan, the percentages of turbidity removal in low, medium and high turbidities were obtained as 86.7%, 95.8%, 97.8% and 86.67%, 95.73%, 98.26%, respectively. When the rapid mixing unit was emitted, the efficiency of turbidity removal in the low turbidity was reduced from 5.26% to 21.73%. But, in higher turbidity in two states (presence and absence of the rapid mixing units) it did not have a significant difference. This study showed that the removal of the rapid mix unit on the removal efficiency of turbidity in the low turbidity is effective, but does not have an effect on higher turbid water. Also, using PACl in conjunction with chitosan was effective in the removal efficiency and to reduce residual aluminum.