bluuebunny/crossref_metadata_2025 huggingface dataset:
Дослідження методів аналізу нелінійної динаміки часових рядів
Authors: Білобородова Т.О.
Published: February 2022

Важливою складовою аналізу даних є вилучення значущих ознак про систему, використовуючи дані часових рядів. Більшість методів традиційного аналізу, зосереджена на даних часових рядів або частотної області. Аналіз нелінійної динаміки ґрунтується на представленні системи у просторі станів, відображаючи поведінку в n-мірному просторі, осі якого є змінними станами. Традиційні методи дослідження діагностичних ознак, в умовах нестаціонарності даних, не завжди забезпечують необхідну достовірність результатів діагностики фізіологічних процесів. Це зумовлює використання додаткових методів, заснованих на використанні порядкової мережі, та направлених на поділ часових рядів на короткі проміжки часу, протягом яких фізіологічна система знаходиться в стаціонарних умовах. Ентропії є мірами оцінки складності порядкової мережі та означають міру складності, хаотичності чи невизначеності системи.

Проведено дослідження з застосування порядкової мережі та мір оцінки її складності для визначення хаотичних процесів в часових рядах  даних фізіологічних процесів, що можуть вказувати на патологічні відхилення досліджуваних процесів.  Формалізовано процес перетворення часових рядів у порядкову мережу. Виконано реалізацію перетворення часових рядів QRS-комплексів ЕКГ у порядкову мережу та розрахунок мір складності: умовної ентропії перестановки та ентропії глобального вузла. Проведений розвідувальний аналіз даних отриманих результатів умовної ентропії перестановки та ентропії глобального вузла на основі візуалізації кореляцій в даних дозволив якісно оцінити відмінність умовної ентропії перестановки та ентропії глобального вузла для  двох типів зразків QRS-комплексів ЕКГ. Статистична значущість, визначена з використанням t-критерій Стьюдента та значення p-критерію менше 0,05 свідчить, що різниця дисперсії мір для двох типів зразків QRS-комплексів ЕКГ є статистично значущою.

За результатами проведеного дослідження зроблено висновок про доцільність застосування порядкової мережі та мір оцінки її складності для визначення хаотичних процесів в клінічних даних для диференційного аналізу патологічних та нормальних фізіологічних процесів.
Фінансове управління і аналіз прибутком інжинірингових підприємств
Authors: Середа О.О. , Кушал І.М.
Published: February 2022

Стаття присвячена актуальним питанням фінансового управління прибутком інжинірингових підприємств. Метою дослідження є розвиток теоретико-прикладних положень щодо управління прибутком інжинірингових підприємств. В проведених дослідженнях використані методи співставлення, системного та аналітичного підходів, дедукції, діалектичної і формальної логіки.  Визначено сутність та виокремлено відмінні риси інжинірингових послуг, які полягають у нематеріальності, корисному ефекті, виробничому та комерційному характері, професійності та інноваційності. Перевагою запропонованого методичного забезпечення управління прибутковістю є врахування специфіки фінансової діяльності таких підприємств: наявність широкої номенклатури та типів послуг, диференціація послуг інжинірингу залежно від масштабів діяльності та попиту на послуги, різний рівень рентабельності окремих послуг. Доведено, що для управління витратами інжинірингового підприємства найбільш прийнятними є АВС – метод та операційний аналіз. Встановлено послідовність поетапної реалізації моделі беззбитковості, яка враховує особливості діяльності інжинірингових підприємств. З метою оперативного управління запропоновано впровадження моніторингу «витрати – доходи – прибуток» та сформовано систему аналітичних показників з метою оцінки тенденцій зміни минулого та поточного рівня прибутковості, а також прогнозування зміни прибутку в залежності від доходів та витрат на основі сценарного підходу. Надано рекомендації щодо оптимізації доходів інжинірингового підприємства на основі механізму ціноутворення, який враховує фактори, пов'язані з інжинірингом (час, інноваційність, масштаби діяльності потенційного замовника, кількість осіб, що володітимуть новими знаннями) та вибір метода встановлення ціни. Обґрунтовано критерії вибору інструментів стратегічного управління прибутком інжинірингового підприємства, пріоритетним обрано модель економічної доданої вартості. Розвиток теоретико-прикладних положень щодо управління прибутком інжинірингових підприємств має практичну спрямованість, результати можуть бути використані для розвитку інжинірингових підприємств.
Post-weaning growth and blood parameters of milk replacer fed and naturally suckled Black Bengal kids
Authors: Moniruzzaman M , Afroz S , Khatun A , Alam MH , Islam MN , Amin MR
Published: February 2022

The present study was carried out to know the effect of feeding soybean-based milk replacer on post-weaning growth and blood parameters of milk replacer-fed and naturally suckled goat kids. Twenty four Black Bengal kids were allocated into two groups; treatment group (n=12, 6 male and 6 female) was reared artificially with milk replacer, and control group (n=12, 6 male and 6 female) was kept with their dam for natural suckling. Milk replacer was prepared with powdered milk and soybean powder (1:1). After weaning, the live weight of kids was recorded weekly. The blood samples were collected from the kids to determine haematological parameters. The live weight did not differ significantly between artificially fed and naturally suckled male and female kids. Wither height and heart girth showed significantly (p<0.05) higher in the milk replacer fed male kids than naturally reared males. Body length of female kids was significantly (p<0.05) higher in milk replacer fed group than naturally suckled group. Heart girth and red blood cell (RBC) were found significantly (p<0.05) higher in artificially fed kids than naturally reared both male and female kids. Therefore, it can be concluded that artificial feeding with milk replacer can be an alternative way of kid rearing under farm conditions.

Bang. J. Anim. Sci. 2021. 50 (2): 86-91
Cross Elasticity of Demand of Selected Wooden Furniture in Respect to Alternative Furniture in Chittagong City
Authors: Miah Md Danesh , Fatema Nowrin
Published: February 2022

A large market of furniture has developed in Chittagong city within the last two decades. There is no much research work on cross elasticity of demand on wooden furniture of Chittagong city. The study attempts to know the effect of several selected factors on wooden furniture. It accomplishes with a semi-structured questionnaire and collects data from 150 households randomly. It hypothesizes that alternative products to wooden furniture are good substitutes. The study identifies that the wooden furniture as a relatively necessary product has an elasticity measurement of less than 1 concerning the alternative products. The cross elasticity of wooden furniture to its alternative products’ quantity is 0.30012 at a positive relationship (p<0.001), to the price of the alternative products 0.07155 at a negative relationship (p<0.10) and to family size 0.2825 at a positive relationship (p<0.05). Furthermore, regression analysis and elasticity measurement confirm that alternative products to wooden furniture are not substituted goods. Hence, the study nullifies the hypothesis. Again, it signifies that the increase in wooden furniture products’ demand is much higher than the increase in alternative products. Furthermore, it indicates that wooden furniture is luxury goods in some households. The income and quantity demanded of the furniture are comparatively higher in their private apartment than that of the rented apartment. The study will be useful in developing furniture industries in the Chittagong city of Bangladesh.
The Chittagong Univ. J. Sci. 43(1): 1-20, 2021
Beiträge zur Nordasiatischen Kulturgeschichte. Hrsg. Gerhard Doerfer und Michael Weiers. – Tungusica. Band I. Hrsg. Michael Weiers; Gerhard Doerfer, Wolfram Hesche & Hartwig Scheinhardt Lamutisches Wörterbuch
Authors: Janhunen Juha
Published: February 2022

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Károly Rédei Syrjänische Chrestomathie mit Grammatik und Glossar
Authors: Bartens Raija
Published: February 2022

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Marianne Sz. Bakró–Nagy Die Sprache des Bärenkultes im Obugrischen
Authors: Janhunen Juha
Published: February 2022

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Kanteletar. Alte Volkslieder und Balladen aus Finnland. Ausgewählt und übertragen von Erich Kunze
Authors: Schellbach Ingrid
Published: February 2022

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Károly Rédei Die syrjänischen Lehnwörter im Wogulischen
Authors: Liimola Matti
Published: February 2022

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Dominik Schröder Aus der Volksdichtung der Monguor 1–2
Authors: Halén Harry
Published: February 2022

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Studies in Shamanism. Based on Papers Read at the Symposium on Shamanism Held at Åbo on the 6th-8th of September, 1962. Ed. by Carl-Martin Edsman; Fatalistic Beliefs in Religion, Folklore and Literature. Papers Read at the Symposium on Fatalistic Beliefs
Authors: Schellbach Ingrid
Published: February 2022

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István Szathmári Régi nyelvtanaink és egységesülö irodalmi nyelvünk; Nord-ostjakische Texte mit Skizze der Grammatik. Gesamm. und hrsg. von Károly Rédei
Authors: Schellbach Ingrid
Published: February 2022

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Grammatikalische Aufzeichnungen aus ostjakischen Mundarten von K. F. Karjalainen, bearb. und hrsg. von E. Vértes
Authors: Liimola Matti
Published: February 2022

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Ivar Paulson, Åke Hultkranz & Karl Jettmar Die Religionen Nordeurasiens und der amerikanischen Arktis
Authors: Schellbach Ingrid
Published: February 2022

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E. Laugaste Eesti rahvaluuleteaduse ajalugu. Valitud tekste ja pilte
Authors: Talve Ilmar
Published: February 2022

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Zoltán Ujváry, A temetés paródiája; István Dobrossy, Dohánytermesztés a Nyírségben; Ernö Kunt Temetök az Aggteleki-karszt falvaiban; László Szabó A magyar rokonsági rendszer; Elek Bartha A hitélet néprajzi vizsgálata egy zempléni faluban; Lázsló Dám Lakóh
Authors: Schellbach Ingrid
Published: February 2022

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Boris Serebrennikow 1915–1989
Authors: Turkin Adolf
Published: February 2022

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Uralisch *kal3 'Netz'?
Authors: Katz Hartmut
Published: February 2022

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Erhard Schiefer Nominalsatz und "Seins- Verb" im Ostjakischen
Authors: Vertés Edith
Published: February 2022

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Peter Hajdú & Péter Domokos Die uralischen Sprachen und Literaturen. Teil I: Die uralischen Sprachen. Teil II: Die uralischen Literaturen
Authors: Winkler Eberhard
Published: February 2022

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Synchrone und diachrone Kasusfragen
Authors: Schlachter Wolfgang
Published: February 2022

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Statistique de fréquence et grammaire comparée
Authors: Sauvageot Aurélien
Published: February 2022

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Die Fragepartikel mo des Tscheremissischen
Authors: Erdödi József
Published: February 2022

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liderazgo institucional y su incidencia en el clima laboral para la formación de la interdisciplinariedad en el colegio Vicente Rocafuerte.
Authors: Ferrin-Plaza Angel , Villacis-Zambrano Angelica
Published: February 2022

El presente artículo de investigación tiene como finalidad presentar un estudio y análisis sobre la incidencia del liderazgo institucional que ocurre en el clima laboral de la Unidad Educativa Vicente Rocafuerte, enfocado en la formación de interdisciplinariedad entre los docentes que laboran en mencionada institución educativa, ubicada en la ciudad de Guayaquil.  
      Este artículo académico es de revisión teórica, es decir, se basa en la búsqueda de información de fuentes confiables, tales como, artículos de revista, libros, bases de datos, entre otros, aplicando metodologías que sugieren los académicos expertos en el ámbito de la investigación científica en concordancia con las variables de estudio.
Para la realización de esta investigación se utilizará el método analítico, mediante la recopilación de información como base teórica sobre la gestión educativa, el liderazgo en la cultura organizacional; así mismo, para realizar el análisis de la problemática se trabajará con el método hipotético-deductivo, empleando el proceso inductivo mediante la observación y deductivo a través de la generación de hipótesis y sus posibles resultados.            
Finalmente, para alcanzar los objetivos de la investigación y dar solución a la problemática a través de la propuesta se identifica un modelo de liderazgo enmarcado en las buenas prácticas sociales, mismo que su comportamiento será analizado y estudiado desde un enfoque de observación directa, ya que comprenderá de realidades complejas y simbólicas, para obtener resultados que se asemejen a la realidad del entorno laboral en la unidad de estudio.
gestión educativa que impulsa a los neobachilleres para enfrentar los retos de la sociedad
Authors: Bermúdez-Checa Tania
Published: February 2022

El objetivo de este estudio fue analizar la dinámica de una gestión educativa que impulsa a los neo bachilleres a enfrentar con justicia, solidaridad e innovación los retos de la sociedad. La metodología empleada fue de revisión teórica y documental, los buscadores académicos que respaldan y robustecen el estudio responden a ScienceDirect, Ovid Embase, EBSCO, PROQUEST Sociological, Redalyc.org, SCIELO, ELSEVIER, visibilizada en una matriz de 61 artículos teóricos e investigativos cuyos aportes fueron poco a poco quitando el sesgo, producto de la percepción inicial y conduciendo hacia la mirada científica y sustentada con base en la problemática. Siendo el principal problema que más del 40% de los graduados no logran una inserción laboral debido a la falta de experiencia práctica, lo cual tiene un fuerte impacto en el desarrollo de competencias laborales de los bachilleres y, por ende, en el motor productivo nacional. Muchos autores coinciden que la gestión educativa tiene un rol preponderante ya que su proceso transformador, planificado y contextualizado permitirá el mejoramiento de la calidad en los perfiles académicos de salida. En conclusión, las acciones eficaces que realice la gestión educativa orienta e impulsa a los bachilleres a enfrentar los retos laborales; el implementar herramientas de forma integrada a fin de garantizar que las competencias desarrolladas durante todo su proceso formativo les permita dominar de forma eficaz los conocimientos adquiridos, permitiéndoles obtener seguridad, fluidez al hablar y un comportamiento que les ayude a obtener un empleo con base en las capacitaciones recibidas de forma responsable y oportuna.
mirada hacia la educación inclusiva de calidad mediante el uso adecuado de herramientas tecnológicas en la institución Simón Bolívar.
Authors: Riofrio-Villamar Natali , Farro-Acosta Jeniffer , Prieto-López Yeimer
Published: February 2022

El presente artículo se plantea por la necesidad de ajustar la educación inclusiva través del uso de estrategias teóricas o tecnológicas durante el tiempo de pandemia del Covid-19, esto fue un reto para directivos, docentes, estudiantes y padres de familia debido a que no contaban con los conocimientos necesarios sobre el uso de las Tic.
El objetivo principal de nuestro artículo fue aportar una Estrategia Teórica direccionada a los docentes para el uso de herramientas tecnológicas que permitan llevar a cabo una educación inclusiva de calidad en la institución Simón Bolívar.
La tecnología juega un papel importante en el proceso de enseñanza y aprendizaje permitiendo que los estudiantes adquieran conocimientos de manera personalizada de acuerdo con sus necesidades especiales.
La utilización de la metodología reside en la revisión bibliográfica de publicaciones científicas relacionado con temas de educación inclusiva basándonos en la sistematización teórica de acuerdo con la problemática estudiada, utilizando los enfoques cualitativo y cuantitativo, con el enfoque cualitativo recolectamos la información y con el enfoque cuantitativo se realizó el análisis de los resultados obtenidos en las técnicas de recolección de datos, facilitando así las estadísticas necesarias.
Para concluir se implementará un proceso de capacitación para que los docentes se encuentren preparados en la utilización de las herramientas tecnológicas del siglo XXI y así lograr una educación interactiva a través de las diferentes plataformas virtuales que permitan un aprendizaje significativo, inclusivo y de calidad.
gestión educativa y su relación con el liderazgo organizacional en la Unidad Educativa “11 de Octubre”.
Authors: Chachipanta-Beltrán Jessica , León-Santillán Eliana , Prieto-López Yeimer
Published: February 2022

Las instituciones educativas requieren que sus colaboradores se sientan comprometidos y empoderados por el progreso y bienestar del establecimiento. Para esto es necesario que los gestores educativos realicen una distribución equitativa de las actividades, generen cambios y mejoras para el centro educativo, permitiendo así el desarrollo institucional a través de acciones que apoyan y fomentan el trabajo en equipo. El objetivo general de la investigación fue aportar una concepción teórica de gestión educativa y su impacto en el liderazgo organizacional de la Unidad Educativa “11 de octubre”, determinando los fundamentos teóricos que sustentan la gestión educativa. Metodológicamente el artículo científico se estructuró bajo un tipo de investigación descriptiva no experimental, empleando el método inductivo-deductivo, histórico-lógico y el análisis-síntesis, lo que permitió obtener información relevante sobre la percepción de las dos variables estudiadas: gestión educativa y liderazgo organizacional. Así también en referencia a los métodos y técnicas del nivel empírico se utilizó el criterio de expertos y las entrevistas. Entre las principales conclusiones encontradas, se estableció la relación existente entre el gestor educativo y el liderazgo organizacional, así como también la importancia de su aplicación en el sistema educativo en referencia a la mejora de los procesos y el impacto positivo en la creación de un clima organización que promueva la labor de los docentes y directivos.
Bibliometric Study of African Publications in Dental Medicine in Indexed Journals between 2008 and 2018
Authors: A Bennani , M Hamza , C Kalali , A Jari
Published: February 2022

Introduction: The objective of this work is to make a bibliometric analysis of publications in odontology of African universities between January 2008 and December 2018 based on publications published in indexed journals on Pubmed. Material and Methods: Our work is a comprehensive retrospective descriptive study intended to carry out a bibliometric analysis of articles in odontology published between January 1, 2008 and December 31, 2018 by professor researchers from African universities. For each selected article, we determined the authors, the title, their affiliations, the year of publication. Results: Based on our sample of 19 African countries (Morocco, Algeria, Tunisia, Egypt, Nigeria, Cameroon, Côte d 'Ivoire, Ethiopia, Ghana, Guinea, Kenya, Libya, Madagascar, Mali, South Africa, DRC Congo, Senegal, Sudan, Zimbabwe) that included 66 faculties; the results of our study showed: In terms of the number of global publications, Egypt, Nigeria, Morocco and South Africa are the leading countries. With them 4, they account for nearly 80% of the published articles. Côte d 'Ivoire, Cameroon, Guinea and Mali do not participate. The number of African authors who have published is 489, which represents 38.99 per cent of all teaching researchers. South Africa Pr. Feller L ranks 1st with 61 published articles. Cross-sectional descriptive studies lead with an overall percentage of 37.84%. In vitro experimental studies account for 27.75%. Literature and systematic journals 10.50%. Case reports studies represent only 9.38%. Clinical trials with a percentage of 9.35%. Prospective and retrospective studies account for 3.44%. Meta-analyzes 1.39%. In the disciplines of published articles, conservative odontology represents 22.82%, periodontology 20.19%, surgical odontology 16.50%, orthodontics 16.42%, prosthesis 15.35% and pedodontics 8.70%. The contribution of Moroccan authors is 12.47%. Moroccan Pr.Bourzgui ranks 4th with 16 items. Discussion: The results show that African universities have made significant progress; however, they are still very far behind European and American universities in terms of scientific publications in odontology. Conclusion: Despite the efforts of academic teachers in the publication of scientific articles in odontology, the number of publications remains low, hence the obligation to adopt a new approach in the future. African academic institutions need to make greater efforts in the field of scientific research in all its forms by creating departments focused primarily on research and by increasing the budget Devoted to this purpose.
Realization of Bonded Restorations with Partial Anchorage: A Survey among Dentists in Private Practice in Casablanca Morocco
Authors: MOUSSAOUI Houda , LAGHZAOUI Salwa , ZOUINI Amina , HAMZA Mouna , BENNANI Anas
Published: February 2022

Objectives: The aim of this study was to assess the prevalence of realization of resin-bonded partial-coverage restorations and to determine the frequencies of reasons to indicate theses restorations in dental office. Methods: In this cross-sectional study, a 22-question questionnaire was sent to 309 practitioners randomly selected from a list provided by the South Regional Council of Dental Registry. Average significance and Chi-square tests were used to identify the frequency, pattern, and significance of the response variables identified. Results: The response rate of our study was 79,6%. Our survey revealed that 52,4% of practitioners use resinbonded prosthesis in their daily practice. For the 47,6% who avoided it, the principal reasons were lack of training and the high price of bonding products. 81,1% of dentists have reported the need of continuing training in adhesive prosthesis and the type of training the most chosen was practical workshops for 55,5% of practitioners. Also, veneers (73,6%), resin bonded fixed partial dentures (58,9%) and inlays (58,1%) were the more used types of resinbonded partial-coverage prosthesis according to our study. Discussion: Similarly to several studies on adhesive prosthesis, our study showed that resin-bonded partialcoverage restorations are not frequently used comparing to cemented restorations. This is due to the lack of training and practice. For that, the major part of practitioners of our study and of similar ones, reported the need of continuing training to stay updated with the new technics in dentistry and to provide quality services to patients. Conclusion: The evolution of adhesive materials and the emergence of new techniques powered a change in the restorative adhesive dentistry. This requires practitioners to update knowledge and skills regularly to match the changing complexity of healthcare needs
The Management of Down Syndrome
Authors: Okpala Peterchris , Okpala Sandra
Published: February 2022

Down syndrome occurs when individuals experience abnormal cell division, resulting in a partial or complete copy of chromosome 21. Persons with Down syndrome have short necks, protruding tongues, poor muscle tones, flattened faces, and excessive flexibility. The genetic disorder affects approximately 400,000 adults and children in the United States. Unmanaged Down syndrome leads to serious health complications like ear infections, eye diseases, heart defects, hearing loss, seizures, gastrointestinal disorders, obesity, and obstructive sleep apnea. The literature review completes a comprehensive analysis of pharmacological and non-pharmacological methods for managing Down syndrome to protect individuals from adverse complications. Specifically, the report examines the benefits of medications, such as donepezil, rivastigmine, memantine, and galantamine, in managing Down syndrome associated with dementia. They review the impact of non-pharmacological methods, including speech therapy, occupational therapy, physical therapy, assistive technologies, and surgeries, on managing Down syndrome. The collection of data for the literature review is based on secondary research. Particularly, the researcher collected and applied data from peer-reviewed journals, e-books, or agencies reports published between 2011 and 2021. The literature review has specific gaps as the peer-reviewed articles did not provide information on particular surgeries for managing complications of Down syndrome, the accurate dosage of medications for adults and children, and the side effects of pharmacological methods. Although the literature has gaps, patients and clinicians should apply the discussed pharmacological and non-pharmacological strategies for managing Down syndrome. The clinical significance of the literature review is to: • Facilitate the early intervention and management of Down syndrome. • Reduce the adverse complications of Down syndrome in children and adults. • Enhance knowledge and awareness of Down syndrome and its evidence-based management approaches among clinicians, vulnerable persons, and community members. • Increase the safety and clinical outcomes of individuals with Down syndrome.
A Case of Syphilitic Chancre of the Tongue
Authors: G Galdava , S Liluashvili , V Kvirkvelia
Published: February 2022

Initial presentation of syphilis may be the oral cavity. Because oral lesions are highly contagious, it is vital to make correct diagnosis and start therapy because interrupt chain of infection. In this article, we report a case of primary syphilis with extra genital chancre on the tongue.
Digital Necrosis as Initial Manifestation of Multiple Myeloma: An Unusual Case Report
Authors: Zrikem Hind , Raissi Abderrahim , Amrani Idrissi Salma , Yahyaoui Hicham , Abbassi Saloua , Ait Ameur Mustapha , Chakour Mohammed
Published: February 2022

Clinical manifestations of multiple myeloma are variable. The authors report a 68-year-old female who presented to the hospital with bilateral digital necrosis and dry gangrenous toes in both left and right feet. She was diagnosed with IgA-λ multiple myeloma associated with Type I cryoglobulinaemia. Emergency management consisted in hyperhydration (plasmapheresis was not available) and thromboprophylaxis. Necrotic digits were amputated. Chemotherapy (bortezomib, lenalidomide, and dexamethasone) was started with good initial evolution. This uncommon presentation can easily be missed, and clinicians should be aware of a possible underlying malignancy.
Careers of New Chinese Professional Women
Authors: Yu Yinghua
Published: February 2022

This paper considers a specific cohort of new Chinese professional women born under the one-child policy in the People's Republic of China (PRC). It explores their perceptions and experiences of career in Australia through qualitative data collected from twenty-one professionals. This paper seeks to unpack the complexities of their career planning, pathways, and change, including their use of the WeChat platform to mediate their careers. I argue that new Chinese professional women's experience of career is ambivalent. They aspired to achieve some degree of 'freedom' through choosing to further their career in Australia; simultaneously, they attempted to build homeland connections and fulfil familial obligations as Dushengnv. As a result of constant negotiation, their career pathways were full of 'nonlinear' changes. WeChat works specifically as one important platform that structures the ambivalence experienced – it allows them to establish connections with family in China and the local ethnic community, but it may also limit their ability to develop networks in the Australian workplace; it offers opportunities for entrepreneurship, yet it complicates their social positions. The paper contributes to broader knowledge of new Chineseprofessional women's careers.
Moving on, Looking Back: Letters from Australia
Authors: Rowe David , Noble Greg
Published: February 2022

N/A
Integrated Analysis of MATH-Based Subtypes Reveals a Novel Screening Strategy for Early-Stage Lung Adenocarcinoma
Authors: Li Chang , Tian Chen , Zeng Yulan , Liang Jinyan , Yang Qifan , Gu Feifei , Hu Yue , Liu Li
Published: February 2022

Lung adenocarcinoma (LUAD) is a frequently diagnosed cancer type, and many patients have already reached an advanced stage when diagnosed. Thus, it is crucial to develop a novel and efficient approach to diagnose and classify lung adenocarcinoma at an early stage. In our study, we combined in silico analysis and machine learning to develop a new five-gene–based diagnosis strategy, which was further verified in independent cohorts and in vitro experiments. Considering the heterogeneity in cancer, we used the MATH (mutant-allele tumor heterogeneity) algorithm to divide patients with early-stage LUAD into two groups (C1 and C2). Specifically, patients in C2 had lower intratumor heterogeneity and higher abundance of immune cells (including B cell, CD4 T cell, CD8 T cell, macrophage, dendritic cell, and neutrophil). In addition, patients in C2 had a higher likelihood of immunotherapy response and overall survival advantage than patients in C1. Combined drug sensitivity analysis (CTRP/PRISM/CMap/GDSC) revealed that BI-2536 might serve as a new therapeutic compound for patients in C1. In order to realize the application value of our study, we constructed the classifier (to classify early-stage LUAD patients into C1 or C2 groups) with multiple machine learning and bioinformatic analyses. The 21-gene–based classification model showed high accuracy and strong generalization ability, and it was verified in four independent validation cohorts. In summary, our research provided a new strategy for clinicians to make a quick preliminary assisting diagnosis of early-stage LUAD and make patient classification at the intratumor heterogeneity level. All data, codes, and study processes have been deposited to Github and are available online.
Redox-Hopping-Based Charge Transport Mediated by Ru(II)-Polypyridyl Species Immobilized in a Mesoporous Metal-Organic Framework
Authors: Duan Jiaxin , Goswami Subhadip , Hupp Joseph T.
Published: February 2022

Electronic charge transport through crystalline metal-organic frameworks (MOFs) can be accomplished by site-to-site electron (or hole) hopping, provided that redox-active sites, such as easily reducible or oxidizable MOF linkers, are present. If the framework itself is redox-inert, solvent-assisted ligand incorporation of redox-active moieties can serve to enable hopping-based charge transport. Here we have studied the redox hopping process within Ru-bpy@NU-1008, where Ru-bpy is a carboxylate-functionalized derivative, i.e., a node-ligating derivative, of the well-known chromophore Ru(2,2′-bipyridine)32+, and NU-1008 is a redox-inert MOF featuring hierarchical porosity and csq topology. Chronoamperometry experiments with electrode-supported thin films of Ru-bpy@NU-1008 show that charge transport is feasible through portions of the MOF, with other portions being inaccessible. Possible confounding features are the undersized c-pores that cross-connect 1D mesoporous channels, as ingress and egress of charge-compensating anions is believed to accompany the net oxidation of Ru(II) to Ru(III) and the reduction of Ru(III) to Ru(II). Phenomenologically, transport through the electroactive portion of the films is diffusion-like, with the magnitude of the apparent diffusion coefficient being 6 × 10−12 cm2/s.
Photoelectrochemical CO2 Reduction Products Over Sandwiched Hybrid Ga2O3:ZnO/Indium/ZnO Nanorods
Authors: Jang Hye Ji , Yang Ju Hyun , Maeng Ju Young , Joo Min Hee , Kim Young Jun , Rhee Choong Kyun , Sohn Youngku
Published: February 2022

Recycled valuable energy production by the electrochemical CO2 reduction method has explosively researched using countless amounts of developed electrocatalysts. Herein, we have developed hybrid sandwiched Ga2O3:ZnO/indium/ZnO nanorods (GZO/In/ZnONR) and tested their photoelectrocatalytic CO2 reduction performances. Gas chromatography and nuclear magnetic spectroscopy were employed to examine gas and liquid CO2 reduction products, respectively. Major products were observed to be CO, H2, and formate whose Faradaic efficiencies were highly dependent on the relative amounts of overlayer GZO and In spacer, as well as applied potential and light irradiation. Overall, the present study provides a new strategy of controlling CO2 reduction products by developing a sandwiched hybrid catalyst system for energy and environment.
Evaluating the Impact of Voice Activity Detection on Speech Emotion Recognition for Autistic Children
Authors: Milling Manuel , Baird Alice , Bartl-Pokorny Katrin D. , Liu Shuo , Alcorn Alyssa M. , Shen Jie , Tavassoli Teresa , Ainger Eloise , Pellicano Elizabeth , Pantic Maja , Cummins Nicholas , Schuller Björn W.
Published: February 2022

Individuals with autism are known to face challenges with emotion regulation, and express their affective states in a variety of ways. With this in mind, an increasing amount of research on automatic affect recognition from speech and other modalities has recently been presented to assist and provide support, as well as to improve understanding of autistic individuals' behaviours. As well as the emotion expressed from the voice, for autistic children the dynamics of verbal speech can be inconsistent and vary greatly amongst individuals. The current contribution outlines a voice activity detection (VAD) system specifically adapted to autistic children's vocalisations. The presented VAD system is a recurrent neural network (RNN) with long short-term memory (LSTM) cells. It is trained on 130 acoustic Low-Level Descriptors (LLDs) extracted from more than 17 h of audio recordings, which were richly annotated by experts in terms of perceived emotion as well as occurrence and type of vocalisations. The data consist of 25 English-speaking autistic children undertaking a structured, partly robot-assisted emotion-training activity and was collected as part of the DE-ENIGMA project. The VAD system is further utilised as a preprocessing step for a continuous speech emotion recognition (SER) task aiming to minimise the effects of potential confounding information, such as noise, silence, or non-child vocalisation. Its impact on the SER performance is compared to the impact of other VAD systems, including a general VAD system trained from the same data set, an out-of-the-box Web Real-Time Communication (WebRTC) VAD system, as well as the expert annotations. Our experiments show that the child VAD system achieves a lower performance than our general VAD system, trained under identical conditions, as we obtain receiver operating characteristic area under the curve (ROC-AUC) metrics of 0.662 and 0.850, respectively. The SER results show varying performances across valence and arousal depending on the utilised VAD system with a maximum concordance correlation coefficient (CCC) of 0.263 and a minimum root mean square error (RMSE) of 0.107. Although the performance of the SER models is generally low, the child VAD system can lead to slightly improved results compared to other VAD systems and in particular the VAD-less baseline, supporting the hypothesised importance of child VAD systems in the discussed context.
Process Drivers, Inter-Model Spread, and the Path Forward: A Review of Amplified Arctic Warming
Authors: Taylor Patrick C. , Boeke Robyn C. , Boisvert Linette N. , Feldl Nicole , Henry Matthew , Huang Yiyi , Langen Peter L. , Liu Wei , Pithan Felix , Sejas Sergio A. , Tan Ivy
Published: February 2022

Arctic amplification (AA) is a coupled atmosphere-sea ice-ocean process. This understanding has evolved from the early concept of AA, as a consequence of snow-ice line progressions, through more than a century of research that has clarified the relevant processes and driving mechanisms of AA. The predictions made by early modeling studies, namely the fall/winter maximum, bottom-heavy structure, the prominence of surface albedo feedback, and the importance of stable stratification have withstood the scrutiny of multi-decadal observations and more complex models. Yet, the uncertainty in Arctic climate projections is larger than in any other region of the planet, making the assessment of high-impact, near-term regional changes difficult or impossible. Reducing this large spread in Arctic climate projections requires a quantitative process understanding. This manuscript aims to build such an understanding by synthesizing current knowledge of AA and to produce a set of recommendations to guide future research. It briefly reviews the history of AA science, summarizes observed Arctic changes, discusses modeling approaches and feedback diagnostics, and assesses the current understanding of the most relevant feedbacks to AA. These sections culminate in a conceptual model of the fundamental physical mechanisms causing AA and a collection of recommendations to accelerate progress towards reduced uncertainty in Arctic climate projections. Our conceptual model highlights the need to account for local feedback and remote process interactions within the context of the annual cycle to constrain projected AA. We recommend raising the priority of Arctic climate sensitivity research, improving the accuracy of Arctic surface energy budget observations, rethinking climate feedback definitions, coordinating new model experiments and intercomparisons, and further investigating the role of episodic variability in AA.
A Downscaling Intercomparison Study: The Representation of Slope- and Ridge-Scale Processes in Models of Different Complexity
Authors: Kruyt Bert , Mott Rebecca , Fiddes Joel , Gerber Franziska , Sharma Varun , Reynolds Dylan
Published: February 2022

Spatially distributed meteorological information at the slope scale is relevant for many processes in complex terrain, yet information at this sub-km spatial resolution is difficult to obtain. While downscaling to kilometer resolutions is well described in literature, moving beyond the kilometer scale is not. In this work, we present a methodical comparison of three downscaling methods of varying complexity, that are used to downscale data from the Numerical Weather Prediction model COSMO-1 at 1.1 km horizontal resolution to 250 and 50 m over a domain of highly complex terrain in the Swiss Alps. We compare WRF, a dynamical atmospheric model; ICAR, a model of intermediate complexity; and TopoSCALE, an efficient topography-based downscaling scheme. Point-scale comparisons show similar results amongst all three models w.r.t. mean-error statistics, but underlying dynamics are different. Ridge-flow interactions show reasonable agreement between WRF and ICAR at 250 m model resolution. However, at 50 m resolution WRF is able to simulate complex flow patterns that ICAR cannot. Validation against Lidar data suggests that only WRF is able to capture preferential deposition of snow. Based on these findings and the significant reduction in computational costs, ICAR is a cost efficient alternative to WRF at the 250 m resolution. TopoScale performs very well in point-scale comparisons, but it is unclear if this can be attributed to the model itself or to the forcing data and the observations assimilated therein. Further study is required to quantify this effect.
Environment of the Early Pleistocene Banshan Paleolithic Site in the Nihewan Basin, North China
Authors: Yang Jiaxing , Zhang Zhen , Li Yuecong , Wang Fagang , Fan Baoshuo , She Zijing , Xie Hongli , Wang Siyu , Da Shuoqiang
Published: February 2022

The Banshan archaeological site is one of the most important Early Pleistocene Paleolithic sites in the Nihewan Basin in North China. Based on analyses of pollen, grain size and charcoal of 56 samples from a sedimentary profile, we reconstructed the environment of the Banshan site before and after the interval of hominin activity (1.340–1.290 Ma). The results show that before the appearance of hominin activity (1.340–1.324 Ma), the climate of the region was initially cold and wet and then cold and dry. The regional vegetation was mainly Pinus and Picea forest in the earlier stage, and steppe dominated by arid-tolerant plants such as Artemisia and Chenopodiaceae in the later stage. During the period of hominin activity (1.324–1.318 Ma), the climate was warm and wet, the vegetation was mainly Pinus forest, and the site was a lakeside environment which would have provided resources such as food and water for hominins. During 1.318–1.310 Ma, the climate was warm and wet, the lake continued to expand and the lake level rose, which may have forced the hominins to migrate outside the area. During 1.310–1.290 Ma, the climate changed from warm and humid to cold and arid, accompanied by the change of the regional vegetation from forest to forest-grassland. Hominin activity at the Banshan site occurred during the interval of climate change from cold and dry to warm and wet, and it ended with the rise of the ancient lake level at Nihewan and the deterioration of the climate.
Power 5G Hybrid Networking and Security Risk Analysis
Authors: Jiang Yu , Cong Yang , Hu Aiqun
Published: February 2022

5G communication technology provides strong support for the power Internet of Things, and it also introduces new security challenges in the application process of the power industry. Starting from the analysis of the power 5G business requirements, this article proposes five 5G enterprise networking construction plans based on different collaborative processing relationships, and conducts a comparative analysis in security, delay, independence, cost, and staffing. According to the analysis of power business requirements and enterprise networking mode, a hybrid networking architecture of 5G and power communication network is proposed, and the 5G network slicing architecture is re-segmented according to different business scenarios. Finally, the new risks and challenges introduced by 5G technology are analyzed in detail from the four parts of terminal access, edge computing, network channel, and core network. Two important risks pointed are specified through a security risk assessment algorithm. In the future, it is also necessary to further study key technologies such as lightweight authentication algorithms and network slice security isolation to realize the real security use of 5G network in the power industry.
Development and Assessment of an Isotropic Four-Equation Model for Heat Transfer of Low Prandtl Number Fluids
Authors: Su Xingkang , Li Xianwen , Wang Xiangyang , Liu Yang , Chen Qijian , Shi Qianwan , Sheng Xin , Gu Long
Published: February 2022

In the simple gradient diffusion hypothesis, the turbulent Prandtl number (Prt) with a constant of 0.85 is difficult to accurately predict for liquid metals having low Prandtl numbers (Pr), while a four-equation model can improve this solution by introducing the turbulence time-scale into the calculation of turbulent thermal diffusivity. However, the four-equation model’s transport form and numerical stability are so complex that suitable commercial code is lacking. Therefore, an isotropic four-equation model with simple Dirichlet wall boundary conditions is built in the present work. Based on the open-source computational fluid dynamics program OpenFOAM, the fully developed velocity, temperature, Reynolds stress, and heat flux of low Pr fluids (Pr = 0.01–0.05) in the parallel plane are obtained by numerical simulation. The results show that the time-average statistics predicted using the present four-equation model are in good agreement with the direct numerical simulation data. Then, the isotropic four-equation model is used to analyze the flow and heat of liquid metal (Pr = 0.01) in a quadrilateral infinite rod bundle. The numerical results are compared with the various and available experimental relationships. The Nusselt numbers calculated using the isotropic four-equation model are betweenness the available correlations, while the turbulent Prandtl number model using a constant of 0.85 over predicts heat transfer. More detailed local heat transfer phenomena and distribution of low Pr fluids are obtained using the present isotropic four-equation model.
A Case Study to Establish a Basis for Evaluating Geographic Origin Claims of Timber From the Solomon Islands Using Stable Isotope Ratio Analysis
Authors: Watkinson Charles J. , Rees Gareth O. , Hofem Sabine , Michely Lina , Gasson Peter , Boner Markus
Published: February 2022

Global demand for low-cost forest products is leading manufacturers and traders to source timber and wood products from vulnerable nations and delicate ecosystems. One small island nation, the Solomon Islands, is seeing exploitation of natural resources accelerating to such a point that its natural forests may be exhausted by 2036. The main causes of natural forest loss on the archipelago are unsustainable or illegal logging practices. Various laws in consumer countries require that members of industry ensure that only legally sourced timber is placed onto their respective national markets. Those that break these laws or fail to act in a way that is compliant may be subject to harsh penalties. This study aims to establish scientific data to evaluate claims that timber has originated from the Solomon Islands. This will enable Operators to carry out due diligence analysis and permit members of Law Enforcement to conduct forensic investigations. Eighty timber core samples comprising 13 different genera of tropical trees were obtained from mature trees in two sites in the Solomon Islands (Guadalcanal and Kolombangara islands) during the period August 2019 to November 2019 using a Pickering Punch sampling device. Homogenised core samples were subject to δ18O, δ2H, δ13C, and δ34S stable isotope analysis using elemental analysis-isotope ratio mass spectrometry. Additional stable isotope data from relevant taxa and geographic origins (elevation, geographic co-ordinates) were also included in this research as an initial assessment of differences in stable isotope ratios between countries. Results show that significant differences are evident in the stable isotope ratios of the sampled taxa within the Solomon Islands (Guadalcanal and Kolombangara Islands) and between other countries. These data can be used as a basis of evaluation to evaluate origin claims of timber or wood products from the Solomon Islands, particularly Kolombangara Island. Furthermore, in the right context, these data can also be used to establish whether timber or wood products declared to be from origins other than the Solomon Islands have stable isotope ratios that are consistent with data from the Solomon Islands. If not, this would suggest foreign timber/forest products are from elsewhere and are being passed-off as originating from the Solomon Islands.