bluuebunny/crossref_metadata_2025 huggingface dataset:
Challenges Encountered in the Implementation of the Education Program among Senior High School Students in The Philippines
Authors: Gurobat Patricia Mae N. , Lumbu-an Jenevieve D.
Published: January 2022

The K-12 Education Program is a new education curriculum in the Philippines that further develops students' skills and concepts in different strands to prepare them for tertiary education and exhibit competence as lifelong learners; however, its implementation has several drawbacks. Thus, researchers identified and analyzed the typical issues that Sultan Kudarat State University –Laboratory High School SHS students faced in implementing the K-12 Education Program and dealt with those challenges and coping strategies. This study employed the qualitative research design, specifically, the phenomenological approach. Focus group discussion and individual interviews were employed to get the needed data. Based on the study findings, students perceive the new curriculum as a significant burden, with the top challenges of having more years in high school, lack of assistance, and learning facilities. They also agreed on the benefits of the new educational system, which include more knowledge and learning, increased competency, and future career chances. Despite the difficulty adjusting to the K-12 program, they tend to cope with the challenges using various coping strategies such as time management, adjustment, acceptance, peer support, as they are aware of the program's value to their academic advancement. As a result, this research can assist students in preparing for the obstacles they may face in senior high school and recommend possible coping mechanisms.
Physical Fitness Status of Male, and Female Non-Athlete in Nigeria
Authors: Bakinde Surajudeen Tosho
Published: January 2022

The study specifically investigated cardiorespiratory endurance, muscular strength, flexibility, and body composition of male and female non-athletes in Nigeria concerning their physical fitness status. A descriptive research design of survey type was used. The population comprised all 100 non-athletes. Purposive and simple random sampling techniques were used. We structured a questionnaire validated by three experts. A reliability coefficient of 0.70 was obtained using Pearson Product Moment Correlation. Data collection was conducted by the researcher, and two trained research assistants. The four hypotheses were tested using inferential statistics of Chi-square at 0.05 alpha level. The findings of this study showed a significant influence of cardiorespiratory endurance as well as physical fitness of male and female non-athletes. Also, there was a significant influence on muscular strength and physical fitness, flexibility and physical fitness status, as well as body composition and physical fitness status of male and female non-athletes. Non-athlete students should engage in physical activities to promote cardiorespiratory endurance during any exercise. Non-athlete students should engage in regular training with weights or using the weight of the body for resistance during calisthenics exercises to promote muscular strength in them.
Factors Affecting the Students’ Scholastic Performance: A Survey Study
Authors: Briones Stephen Karl F. , Dagamac Rezel Joy R , David Jayson D. , Landerio Cherry Ann B.
Published: January 2022

Academic achievement is one of the essential elements that businesses examine when employing new graduates. This problem calls for intensive survey investigation to find out the Factors Affecting the Academic Performance of Grade 11 students at SKSU-Laboratory High School. This research was conducted to identify the factors affecting the academic performance of students at SKSU-Laboratory High School, which would help provide suggestions that would promote better academic performance that would interest the students in the study area. This study used a questionnaire for quantitative research instruments and has also used a customized method such as an online survey for the study. This study was conducted to explore the different factors that affect students’ academic performance. This study states that the students' environment has excellent effects, enhancing or weakening their academic performance. There are various factors inside and outside school that contribute to the quality of academic performance of students, such as, Parenting Style, Characteristics of the Students, Level of Internet Effectiveness, Teachers Effectiveness, Lack of Motivation, and Students Career Choice are the factors that affect students’ academic performance.
Implementation and Acceptance of Latin Dances in Senior High School Curriculum
Authors: Landero Daryll Jay M. , Gadayan Derick Vince , Valderama Ian M. , Falle Jayson A. , Calixtro Jr. Vivencio L.
Published: January 2022

This study is to determine how Latin dances are implemented and how students accept Latin dances as one of their core subjects. Also, this study was to highlight that there are limited studies related to the implementation and acceptance of Latin dances in the Senior high school curriculum. The study used a quantitative-correlational design and employed a complete enumeration sampling technique in selecting the respondents. The finding shows that Latin dances in the senior high school curriculum were not fully implemented and it needs to be strengthened. The acceptance of Latin dances is slightly accepted. Lastly, it was also concluded that there is a significant relationship between implementation and acceptance of Latin dance in senior high school. Thus, this research can contribute to the development of how Latin Dances teaches in Senior high school, for it provides information about the result about the implementation and acceptance of Latin dances in Senior high school curriculum.
Effect of Technology-Enabled Video Instruction on Senior Secondary School Students’ Performance in Selected Technical Drawing Concept in Ilorin
Authors: Onasanya Temitayo Omolara , Aladesusi Gboyega Ayodeji , Taiwo S. A. , Onasanya Samuel Adenubi , Adeoye Jameson Taiwo
Published: January 2022

The study examined the effect of technology-enabled video instruction (TEVI) on senior secondary school students’ performance in selected technical drawing (TD) concepts in Ilorin. The sample for this study consists of an intact class in a senior secondary school in Ilorin. The research adopted a mixed method of quantitative and qualitative research, pre-experimental research of one-group pretest-posttest design. Technology-Enabled Video was used for data collection. The findings from the study revealed that TEVI had a positive effect on the academic performance of students taught selected TD concept, (63.1˃ 51.5), there was a significant difference in the pretest and posttest performance of students taught selected technical drawing concept using TEVI i.e. (df=15, t=-565, p=.000˂0.05). The study concluded that technology-enabled video instruction which is an improvised instructional aid did enhance the academic performance of the students. The study implies that proper integration of technology-based packages like TEVI for instructional delivery will adequately enhance students’ performance. The study Recommended that TEVI should be encouraged among teachers and students, as this will help to boost learners’ interest and provide learners the ability to learn in a direct, self-paced, and individualistic manner, which will, in turn, translate to better academic performance.
Airport Development Planning (Case Study: Mozes Kilangin International Airport)
Authors: Amri Salsabila Miyazumi , Pagarsukma Muhammad Azhan
Published: January 2022

The aim of this research is to calculating the volume requirements for runways, taxiways and aprons in future conditions based on the planned aircraft CN-235 type. In planning the development of an airport, one must estimate the traffic flow in the future. Therefore, this paper is based on research results. By analyzing the five-year data on the number of aircraft, passengers, luggage and cargo using regression analysis, it can be predicted that the traffic flow in the future so that airport development can be determined whether it is necessary to do or not. Based on primary data obtained from airports such as climatological data, aircraft characteristics data, land data, and existing airport data, it is used as a reference for planning airport development. Based on the results of calculations that refer to the standards of the International Civil Aviation Organization (ICAO) with the CN-235 plan aircraft, it takes a runway length of 3,949 meters and a runway width of 60 meters.  The distance between the runway axis and the runway axis is 185 meters. The total width of the taxiway is 38 meters, and the required apron area is 750.5 × 164 = 123,082 m. Benefit of the Research is as material to consider for evaluating the function of airports in support of faster mobilization in the future
Pioneering Teaching Campus Activities at Elementary School in Balerante, Palimanan, Cirebon, West Java, Indonesia
Authors: Artamevia Nelsa Indah , Nandiyanto Asep Bayu Dani
Published: January 2022

Perintis Teaching Campus is one form of implementing the Independent Campus Learning Policy in the form of teaching assistance to empower students to assist the learning process at elementary schools in various villages / cities throughout Indonesia. The implementation of learning during this pandemic is carried out online. Where teachers are required to really master technology and create media that attracts students' attention so that they do not get bored. Therefore, this program is intended for students to help teachers in conducting distance learning. Of course this activity is very beneficial for schools, students, and students. This activity was carried out at elementary school (SDN 3) in Balerante, Cirebon, Indonesia for 2.5 months.
Introduction of Indonesian Poem (Pantun) as a Creative Effort of Elementary School Students in Improving Language Skills in the Covid-19 Pandemic Era
Authors: Medani Decky Ibrahim , Sakti Asri Wibawa
Published: January 2022

Learning activities are very impactful in the Covid-19 Pandemic Era so students are directed to study at home. Assistance from educators is very important to develop good literacy. With the Thematic Community Service Program, the purpose it is hoped that there will be an increase in student interest in learning and make it easier for educators and parents to carry out online learning activities. Including the introduction of Pantun in improving Language Skills in the Ciparay Hilir Region which is carried out online. The method in this study uses quantitative research. The results of this study are still many students who do not know the type of poem (known as pantun). Students' understanding of Pantun material, Types, and Language Skills by delivering material via PowerPoint or YouTube which is done online, and using the google meet application with educators. The results of the research show that the average post-test score of students is 70% greater than the average pre-test score of 37%, so the difference is 43%. Therefore, during the Covid-19 pandemic, there were still many efforts to increase literacy.
The attitude of Distance Learners towards the Utilization of Learning Management System (A case study of National Open University of Nigeria)
Authors: Ajijola Esther M , Ogunlade Oyeronke Olufunmilola , Aladesusi Gboyega Ayodeji
Published: January 2022

One significant innovative technology to expand teaching and learning mostly in Distance Education is Learning Management System (LMS). LMS allow learning institutions to offer a larger number of courses online whether full or blended, by providing institutions with a digital space for numerous purpose which includes documentation, tracking and online training. However, for the relevance of LMS within an education context, distance learners’ attitudes towards the use of LMS must be investigated. The study therefore aimed at examining the Attitude of Distance Learners towards the Utilization of LMS (A case study of the National Open University of Nigeria). Data were collected from 697 respondents using a research adapted questionnaire. Data collected for the study were analyzed using mean and standard deviation to answer research question one while hypotheses one and two were tested using independent t-test and ANOVA respectively. The findings indicated that there was a significant difference between male and female distance learners on their attitude toward the use of LMS. Thus, no significant difference existed among science, arts, and social science distance learners’ attitude towards the use of LMS. It was therefore recommended that efforts should be made to ensure that distance learners do not just have a positive attitude towards the use of LMS but should be taught the value of LMS to ensure its effective utilization.
Chlorpyrifos should be banned in agriculture and livestock production in Colombia
Authors: Villar David , Schaeffer David J
Published: January 2022

Chlorpyrifos (CPF) is a pesticide widely used in Colombia´s agriculture, including crops, farm animals and pets, despite it has been banned for use in the European Union and the United States. Studies demonstrate that even low blood levels of CPF -which do not inhibit blood acetylcholinesterase- can lead to child developmental and neurological disorders such as smaller head circumference and brain alterations, and psychomotor and cognitive deficits related to learning ability, attention and memory. In adults, CPF is an endocrine disruptor and breast carcinogen. High direct and indirect economic costs have been associated with CPF exposure. Not only farmers and their families -who have the highest exposures- but the general population consuming crops sprayed with CPF are also at risk. For these reasons CPF was recently banned by the European Union (2020) and the USA (2021). Pesticide regulation policies vary greatly depending on which and how scientific studies are used to assess health risks. Pesticide evaluations funded by the chemical industry should be rectified to avoid conflicts of interest. Furthermore, political alignment with the interests of the industry should not take precedence over independent scientific evidence. It is discouraging, to say the least, that until stricter health laws are passed in Colombia, CPFs and related pesticides will continue to be imported from those countries that have already banned them. Colombian scientists should raise their voice to challenge blind acceptance of profits over unintended consequences, and efforts to prevent pesticide´s abuse should be encouraged.
Das Zeitverhalten verteilter Anlagen
Authors: Berger Ulrich , Schöttke Dirk , Kämpfe Thomas
Published: January 2022

Der Wunsch nach Interoperabilität in verteilten Anlagen bei Verwendung durchgängiger Engineeringmethoden ist seit langem Gegenstand der Forschung. Gerade Schnittstellen zwischen Produkten und Systemen unterschiedlicher Hersteller führen in der Praxis oft zu Problemen bei der Fehleranalyse und der Abgrenzung der Leistungsumfänge. Dieser Beitrag behandelt verteilte Systeme, welche echtzeitfähige Komponenten und nicht echtzeitfähige Komponenten beinhalten. Diese Systeme werden als heterogene Systeme bezeichnet. Vorgeschlagen wird die zeitliche Modellierung des Gesamtsystems, bestehend aus dem Prozess, der Kommunikation und der verwendeten Instrumentierung sowie eine Bewertung der zeitlichen Unbestimmtheiten der Subsysteme. Durch die weitere Verwendung des Modells als Online-Beobachter erfolgt eine Überwachung der Prozessführung mit Handlungsempfehlungen.
Smart Meter Gateway als Vorbild für die Automation
Authors: Sikora Axel
Published: January 2022

Die Kommunikationstechnik für die Zählerfernauslesung (Smart Metering) und für die Energieerzeugungs- und -verteilnetze (Smart Grid) hat das Potenzial, zu einer der ersten hoch skalierten M2M-Anwendungen zu werden. In den vergangenen Jahren konnten zwei vielversprechende Entwicklungen im Umfeld der drahtlosen Kommunikation für die Smart-Grid-Kommunikation vorbereitet werden, die das Marktgeschehen über Deutschland und über die Versorgungstechnik hinaus beeinflussen könnten. Neben der Spezifikation der OMS-Gruppe ist die Erarbeitung eines Schutzprofils (Protection Profile, PP) sowie einer Technischen Richtlinie (TR) für die Kommunikationseinheit eines intelligenten Messsystems (Smart Meter Gateway) durch das Bundesamt für Sicherheit in der Informationstechnik (BSI) zu nennen. Diese greifen, wie der Beitrag beschreibt, den Stand der Technik auf und geben praxisorientierte Umsetzungen vor.
Industrie 4.0 ohne modellbasierte Softwareentwicklung
Authors: Niggemann Oliver
Published: January 2022

Industrie 4.0 versucht die Handhabung von komplexen Produktionsanlagen zu verbessern und eine flexible und adaptive Produktion umzusetzen. Aktuell liegt die Hauptschwierigkeit dieser Szenarien bei der Automationssoftware, deren Erstellung zeitaufwändig und fehleranfällig ist. Zur Lösung dieses Problems werden dabei zwei Hauptansätze verfolgt: die modellbasierte Softwareentwicklung und die intelligente Automation, das heißt die Verwendung wissensbasierter Lösungsansätze. Der Beitrag vergleicht beide Ansätze anhand dreier Phasen: der Planungsphase, der Betriebsphase und der Anlagenumbauphase.
Engineering-Effizienz automatisch messen
Authors: Drath Rainer , Messinger Christian , Schröter Ben , Li Nuo , Gutermuth Georg
Published: January 2022

Engineering ist ein wesentlicher Kostenfaktor in der Automatisierung. Daher suchen Industrie und Akademia gemeinsam nach Methoden, um die Engineering-Effizienz zu erhöhen. Leider ist es nicht möglich, solche Methoden objektiv, systematisch, reproduzierbar und vergleichbar zu bewerten, weil sich Engineering-Effizienz bisher einer systematischen Messung entzieht. Dieser Beitrag schlägt erstmals einen Ansatz zur automatischen Messung und Visualisierung der Effizienz von Engineering-Methoden vor, der in Engineering-Werkzeuge eingebettet werden kann. Im Fokus steht dabei die Bewertung der Engineering-Methode, nicht des Menschen. Das Konzept ist auf beliebige Engineering-Werkzeuge übertragbar.
Kommunikation mit AutomationML beschreiben
Authors: Riedl Matthias , Lüder Arndt , Heines Benno , Drath Rainer
Published: January 2022

Kommunikationssysteme sind integraler Bestandteil moderner Steuerungssysteme, da sie die von den Steuerungssystemen genutzten Peripheriegeräte miteinander verbinden. Die Planung von Produktionssystemen und den in sie eingebetteten Steuerungssystemen muss Kommunikationssysteme detailliert berücksichtigen. In jeder Phase des Entwurfs entstehen relevante Daten für den Entwurf des Kommunikationssystems, die in späteren Phasen benötigt werden. Die Weitergabe dieser Planungsinformation im Lebenszyklus des Produktionssystems zwischen den Werkzeugen bildet noch heute ein technisches Problem. Es steht kein passendes Datenaustauschformat zur Verfügung, das eine konsistente und verlustfreie Informationsweitergabe zwischen Entwurfswerkzeugen ermöglicht. Im Rahmen des AutomationML e.V. wurde eine Methode entwickelt, Kommunikationssysteme auf Basis des Datenaustauschformats darzustellen, ausgehend von formalen Modellen. Die Methode wird in diesem Beitrag vorgestellt.
Speed-Standardisierung am Beispiel der PLT-Stelle
Authors: Schüller Andreas , Scholz André , Tauchnitz Thomas , Drath Rainer , Scherwietes Thomas
Published: January 2022

Standardisierung kann dauern. Der standardisierte Datenaustausch von PLT-Stellen zwischen Werkzeugen der Anlagenplanung und der Leittechnik ist bis heute nicht gelungen. Dieser Beitrag beschreibt die erstmalige Anwendung einer neuen und agilen Standardisierungsmethodik am Beispiel von PLT-Stellen. Mit ihrer Hilfe haben Vertreter namhafter Hersteller und Anwender von Planungswerkzeugen innerhalb von nur zehn Monaten im Rahmen des GMA-FA 6.16 einen methodischen Durchstich erreicht. Es wurde ein detailliertes elektronisches Datenmodell der PLT-Stelle erstellt, Ex- und Importer für namhafte CAE-Tools und PLT-Werkzeuge prototypisch entwickelt und der bidirektionale Austausch von PLT-Stellen zwischen ihnen auf der Namur-Hauptsitzung 2014 erfolgreich demonstriert.
Engineering-Workflow-Cockpit
Authors: Gutermuth Georg , Cohen Andrew , Barth Mike
Published: January 2022

Das Engineering von Automatisierungssystemen wird von einer Vielzahl an Personen, Werkzeugen und angewandten Vorgehensweisen bestimmt. Die etablierten Prozesse stoßen angesichts steigender Projektkomplexität, an ihre Grenzen. Zur Beherrschung der Komplexität derartiger Engineeringprojekte beschreibt der vorliegende Beitrag ein Workflow-basiertes Engineering-Cockpit. Dieses Cockpit hat zum Ziel, die Koordinierung von Informationsflüssen in verteilten Projekten zu optimieren und gleichzeitig einen besseren Überblick über alle standardisierten als auch sich verändernde Projektaspekte zu gewährleisten. Als Basis dient eine neuartige Workflowvisualisierung, die auch solche Prozesse untereinander verknüpft, die bislang ausschließlich in Form von Dokumenten oder in den Köpfen erfahrener Projektingenieure in Relation standen. Das Cockpit visualisiert dabei den Projektworkflow und agiert als ein Zentrum für die Interaktion und den Informationsfluss unterschiedlicher Prozesse und Werkzeuge. Gleichzeitig bietet es allen am Projekt beteiligten Teammitgliedern einen konsistenten personalisierten Projektüberblick. Der Beitrag erklärt die Methodik, erläutert eine mögliche Umsetzung und behandelt die kritische Auseinandersetzung mit dem neuen Ansatz.
Disponibilidad léxica, diccionario de onubensismos y enseñanza de la lengua
Authors: Galloso Camacho María Victoria , Martín Camacho Montemayor
Published: January 2022

Los estudios de disponibilidad léxica suponen un reflejo de la realidad léxica de ciertas hablas y son, por lo tanto, un buen punto de partida para observar la pervivencia de dialectalismos con cierto arraigo en una comunidad de habla. La importancia del diccionario como transmisor de conocimientos y realidades culturales únicas es uno de los motivos que nos llevó a la creación de un Diccionario de onubensismos, una obra lexicográfica como forma correcta de presentación de realidades paralelas al uso estándar de la lengua, en la que se han incluido los dialectalismos encontrados en los listados de disponibilidad léxica de Huelva. Las relaciones existentes entre dialectalismos léxicos y el material que ofrecen estos estudios de disponibilidad léxica son, por tanto, evidentes. No son glosarios únicamente destinados a mostrar las peculiaridades dialectales, sino que deben ser usados como herramienta de apoyo en el aula de enseñanza de lenguas ya que permiten trabajar con la realidad lingüística inmediata.
Desemantización verbal desde la perspectiva de la enseñanza de ELE
Authors: Tsutahara Ryo
Published: January 2022

Los verbos más frecuentes suelen tener múltiples usos. En algunos de ellos los verbos están altamente desemantizados y funcionan como verbos de apoyo, pseudocopulativos o forman parte de perífrasis. En este estudio contemplaremos el fenómeno de la desemantización verbal desde la perspectiva docente.  Primero, mostraremos la alta frecuencia del fenómeno y defenderemos la importancia de los usos desemantizados. Después, señalaremos la dificultad de manejar los usos desemantizados para los no nativos. Además, repasando los estudios acerca de estos usos realizados en el ámbito de la lingüística, propondremos una metodología y estrategia para enseñarlos.
Molecular Identification and Ochratoxigenic Potential of Black Aspergillus from Various Substrates and Indoor Environment
Authors: ABDUL RAHMAN WARDAH , ZAKARIA LATIFAH
Published: January 2022

Aspergillus section Nigri or black Aspergillus is characterized by dark brown to black colonies. Several species of this group showcase the ability to produce ochratoxin A (OTA), contaminating various types of food and feed. This study was conducted to identify black Aspergillus isolated from rice, groundnuts, spices, corn grains, soil, and indoor environment and determine the ability of the isolates to produce OTA. Based on ITS, β-tubulin and calmodulin sequences, 177 isolates of black Aspergillus from various substrates and indoor environment were identified as A. niger, A. aculeatus, and A. tubingensis. By using two sets of primers to amplify two ochratoxin biosynthesis genes (PKS15KS and PKS15C-MeT genes), the OTA genes were detected in only six A. niger isolates from rice and indoor environment. These six A. niger isolates produced 8 to 308 µg/g of OTA as quantified using UPLC analysis. No OTA gene was detected in any of the A. tubingensis and A. aculeatus isolates. In conclusion, three black Aspergillus species, A. niger, A. aculeatus, and A. tubingensis, were identified from rice, groundnuts, spices, corn grains, soil, and indoor environment. Only six isolates of A. niger produced OTA indicating most of the A. niger isolates were non-OTA producers. These results could thus portray the occurrence of OTA in the field. Since both the number of isolates producing OTA and the levels of OTA production were low, it could be possibly assumed that the occurrence as well as the levels of OTA in the field are also low.
Flash Flood Susceptibility Mapping of Sungai Pinang Catchment using Frequency Ratio
Authors: Saleh Azlan , Yuzir Ali , Sabtu Nuridah
Published: January 2022

Flash flood are natural disasters that frequently occur in Malaysia especially in urban areas. Due to this, the development of flash flood susceptibility mapping one of the tools used to aid the local authority in reducing and managing the flash flood impact. Frequency Ratio (FR) is a popular method in predictive modeling because of its capabilities to determine the critical conditioning factor of flash flood. The aim of this research was to compare the standalone FR with Ensemble FR-AHP. This ensemble method uses pair-wise comparison method between Frequency Ratio and Analytical Hierarchy Process (AHP). For this research, ten conditioning factors were selected which were slope, aspect, curvature, Topographic Wetness Index (TWI), Stream Power Index (SPI), Normalized Difference Vegetation Index (NDVI), distance from river, rainfall, elevation, and land use/land cover (LULC). The flash flood inventory was obtained from local authorities where the flash flood occurred in Penang, Malaysia on November 2017. 70% of 110 flooded locations were used as training dataset to assess the spatial distribution of flooding whereas the remaining 30% flooded locations were used as validation dataset. Based on the results, the prediction rate of FR-AHP method is slightly better accuracy compared to FR method which 88.33% (FR-AHP) and 85.62% (FR). The output of this research is crucial to assist local authority in land use planning and drainage system of the study area.
Zingiber officinale Roscoe and Piper betleExtracts Enhanced its Chemopreventive Effect against Colon Cancer Cells by Targeting Caspases-Mediated Apoptosis
Authors: Mohd Yusof Yasmin Anum , Abdullah Shailah , Mohd Sahardi Nur Fatin Nabilah , Wan Ngah Wan Zurinah , Makpol Suzana
Published: January 2022

Food regimens and herbs have been a target of scientific research in treating cancer. This study aimed to elucidate the effect of Zingiber officinale (ginger) and Piper betle (PB) alone or in combination on the colorectal cancer cell lines HCT116 and HT29. The chemopreventive effect of these extracts was determined by performing cell viability assay, cell cycle analysis, apoptosis analysis, and caspase 3 and 8 activity assays in HCT116 and p53-deficient HT29 cells. Ginger and PB extracts inhibited the proliferation of both cancer cell lines dose-dependently, but the combined extracts inhibited the growth of cancer cells synergistically with an IC50 PB plus ginger < IC50 PB < IC50 ginger. Similarly, the effect of the combined extracts on apoptosis of both cancer cell lines was higher than that of each individual extract. Consistent with the enhancement of caspase activity, both extracts increased the expression of BAX protein, while Bcl-2 protein was decreased. Flow cytometry analysis indicated that the combined extracts arrested a higher percentage of colon cancer cells at the G0/G1 phase with a concomitant decrease in cells in the S phase, indicating that the combined extracts inhibited human colon cancer cell growth by cell cycle arrest at the G0/G1 phase. The inhibitory effect of these combined extracts on cellular proliferation and the induction of apoptosis was synergistic, showing a significant combination index (CI) value < 1.0. The combined extracts of ginger and PB may serve as a potential chemopreventive agent against colon cancer through the induction of caspase-mediated apoptosis.
Metal Contamination and Stability of Household Bleach and Specially-Formulated Sodium Hypochlorite for Endodontic Use
Authors: Jawami Afiq Azizi , Soo Eason , Abdullah Dalia , Liew Amy Kia Cheen , Abd Rahman Mariati
Published: January 2022

The aims of this in vitro study were to investigate metal contamination and short-term stability of two types of household bleach and a specially-formulated sodium hypochlorite (NaOCl) for endodontic use. The first part of the study was to compare traces of metal elements (Cu, Fe and Ni) between the two types of household bleach (Clorox and Milton) and a specially-formulated NaOCl (CanalProTM 3% NaOCl, Coltene, Whaledent)) using UV spectrophotometer. The second part of the study was to compare the available chlorine and pH of these different NaOCl formulations at different temperatures. Chemical stability of the NaOCl was assessed by measuring the amount of free available chlorine (FAC) using the iodometric titration assay at the temperature of 15, 30, 45, and 60 °C. The pH of the solutions was measured using calibrated pH meter. The results showed that Milton contained significantly higher concentration of Cu, Fe and Ni compared with the other formulations (P < 0.001). Concentrations of Fe detected in Clorox and CanalPro were higher than in the control, distilled water (P < 0.05). In all NaOCl samples, the concentration of available chlorine increased with temperature. Concomitantly, there was a significant decrease in pH with increasing temperature (P < 0.001) with all the NaOCl formulations. In conclusion, traces of metal remnants could be observed in all the NaOCl formulations, especially in Milton. Heating the NaOCl increases the FAC and decreases its pH.
Comparison of Deep Learning Models in Carotid Artery Intima-Media Thickness Ultrasound Images: CAIMTUSNet
Authors: SAVAŞ Serkan , TOPALOĞLU Nurettin , KAZCI Ömer , KOŞAR Pınar
Published: January 2022

Deep learning is a machine learning technique that uses deep neural networks, which are multilayer neural networks that contain two or more hidden layers. In recent years, deep learning algorithms are also used to solve machine learning problems in medicine. Carotid artery disease is a type of cardiovascular disease that can result in a stroke. If a stroke is not diagnosed early, it is in the first place among the disabling diseases and the third place for the most common cause of death after cancer and heart disease. In this study, the classification performances of deep learning architectures in the biomedical field are compared, and Carotid Artery (CA) Intima-Media Thickness (IMT) Ultrasound (US) images were used. For an early diagnosis, AlexNet, ZFNet, VGGNet (16-19), which had successful results in the ImageNet competition, and authors’ original CNNcc models were used for comparison. An image database of CA-IMT-US which contains 501 ultrasound images from 153 patients was used to test the models' classification performances. It is seen that AlexNet, ZFNet, VGG16, VGG19, and CNNcc models achieved rates of 91%, 89.1%, 93%, 90%, and 89.1% respectively. The CNNcc model was found to produce successful classification results on CAIMTUS images when different performance indicators are also taken into account. In addition, different performance indicators including confusion matrices were investigated and the results were announced. The results showed that deep architectures are promising in the biomedical field and can provide proper classification on biomedical images so; this can help clinics to diagnose the disease early.
Comparison of U-Net Based Models for Human Embryo Segmentation
Authors: UYSAL Nefise , YOZGATLI Tahir Koray , YILDIZCAN Ecem Nur , KAR Emre , GEZER Murat , BAŞTU Ercan
Published: January 2022

The quality of human embryos produced during in vitro fertilization is conventionally graded by clinical embryologists and this process is time-consuming and prone to human error. Artificial intelligence methods may be used to grade images captured by time-lapse microscopy (TLM). Segmentation of embryos from the background of TLM images is an essential step for embryo quality assessment as the background of the embryo has various artifacts which may mislead the grading algorithms. In this study, we performed a comparative analysis of automated day-5 human embryo (blastocyst) image segmentation methods based on deep learning. Four fully convolutional deep models, including U-Net and its three variants, were created using the combination of two gradient descent-based optimizers and two-loss functions and compared to our proposed model. The experimental results on the test set confirmed that our customized Dilated Inception U-Net model with Adam optimizer and Dice loss outperformed other U-Net variants with Dice coefficient, Jaccard index, accuracy, and precision of 98.68%, 97.52%, 99.20%, and 98.52%, respectively.
Gündelik Yaşamın Sinemada Örgütlenişi: Küçük Şeyler Filmi Üzerine Bir Analiz
Authors: GÖKMEN Esma
Published: January 2022

Gündelik yaşam, bireylerin gündelik davranış ve pratiklerini içeren temel yaşam alanıdır. Gündelik yaşamın yeniden üretimi ve organizasyonunda en işlevsel alanlardan biri ise hiç kuşkusuz sinemadır. Sinema filmleri gündelik yaşamın pratiklerini ve dinamiklerini içeren ve bunu topluma aktaran araçlardan birini temsil eder. Bu çalışma gündelik yaşamın sinema filmlerinde hangi pratiklerle temsil edildiğini, izleyiciye aktarılan gündelik yaşam biçiminin hangi ekonomik ve siyasal ideolojinin bir parçası olduğunu, kapitalist sistemin ekonomi-politik ve toplumsal ilişkileri temelinde ele almayı amaçlamaktadır. Bu bağlamda yönetmen Kıvanç Sezer’in Küçük Şeyler (2019) adlı filmi örneklem olarak seçilmiş ve sosyolojik film analizi yöntemi kullanılarak filmin gündelik yaşamı nasıl kurguladığı ve organize ettiği belirlenmeye çalışılmıştır. Elde edilen sonuç kapsamında filmde eleştirel bir yaklaşımla kurgulanan gündelik yaşamın, kapitalist bir yaşam tarzı olduğu, bireylerin gündelik eylem ve pratiklerini döngüsel bir ritimle gerçekleştirdikleri ve gündelik yaşamın tüketimle ve kapitalist kültürle dolayımlanan bir yaşam alanı olarak tezahür edildiği görülebilir. Bu durum ise sinemanın toplumsal gerçekliği açığa çıkarma ve mevcut sosyo-ekonomik sisteme eleştirel yaklaşma yönü açısından önemli bir bakış açısı sağlayacaktır
Reklamlarda Ünlü Kullanımı: Effie Award Türkiye Reklamlarına Yönelik İçerik Analizi
Authors: KIR ELİTAŞ Serpil , AKYOL Zöhre
Published: January 2022

Reklamlarda tüketicilerin dikkatini çekmek ve markanın tüketicilerin zihninde yer edinmesini sağlamak amacıyla çeşitli yöntemlerden faydalanılmaktadır. Bu yöntemlerden biri olan reklamlarda ünlü kişilere yer verilmesi (star stratejisi) aracılığıyla markalar tüketicileri etkilemeyi, ürün, hizmet ya da markalarına olan talebi artırmayı amaçlamanın yanı sıra aynı zamanda ünlü kişiler aracılığıyla marka imajı oluşturmak ve markalarına bir ruh ve kişilik kazandırmayı da planlamaktadır. Bu çalışmada Effie Türkiye Reklam Etkinliği Yarışması’nın 2014-2021 yılları arasında yayınlanan reklamları arasından, içinde ünlülerin yer aldığı 117 televizyon reklamı incelenmiştir. Bu reklamlar kullanılan reklam çekicilikleri, yaratıcı stratejiler, mesaj stratejileri, anlatım türleri, anlatım formatları, ünlünün sunulduğu karakter ve ünlünün reklamdaki rolü gibi özelliklere göre değerlendirilmiştir. Araştırmaya göre en fazla kullanılan reklam çekiciliği kalite, en çok kullanılan yaratıcı strateji marka imajı stratejisi, en sık kullanılan mesaj stratejisi işlevsel çekiciliktir. Son olarak en çok kullanılan anlatım türü dolaylı anlatımdır ve incelenen reklamlarda ünlüler daha çok film/ dizi yıldızı/fenomen olarak ve ana karakter rolünde yer almıştır.
Occupational stress as a risk factor and pathogenetic basis for the occurrence of cardiovascular diseases in naval specialists
Authors: Sobolev Alexey D. , Kryukov Evgeniy V. , Cherkashin Dmitry V. , Vypritsky Pavel A. , Kutelev Gennady G. , Sukhoroslova Irina E. , Nikashin Aleksey N. , Pastukhov Aleksey V. , Khomina Viktoria V.
Published: January 2022

The relevance of cardiovascular diseases among the military personnel of the Russian Navy is reflected, as well as the role of occupational stressful load in the formation of a cardiovascular pathology. A single-stage study was carried out, which included 86 men aged 2340 years, during the study were divided into two groups corresponding to the different occupational load. The profile of behavioral factors associated with the cardiovascular risk (anthropometric indicators, adherence to smoking, amount of alcohol consumed, food preference), as well as morphological and functional indicators of the system, was studied in servicemen exposed to and not exposed to factors caused by staying in the deep-sea technical means. blood circulation. The effectiveness of stress testing was assessed, which included the Reeder self-assessment scale for psychosocial stress, the hospital scale for anxiety and depression, a work stress questionnaire, and a differential assessment of the state of a reduced performance. It was revealed that the profile of cardiovascular risk in servicemen of both groups is low, however, there is a significant difference in the number of indicators (the amount of adipose tissue detected by bioimpedansometry, total cholesterol level, an increase in heart rate during the psychomental test, values of vascular age and scale of relative cardiovascular risk. The most informative method, which made it possible to identify significant differences between the studied groups, is the questionnaire of the work stress by C. Spielberg 1989, adapted by A.B. Leonova and S.B. Velichkovskaya, 2000. It was determined that the severity of the impact of occupational stress factors in the servicemen exposed to factors caused by their stay in the deep-sea technical means is lower than in servicemen in the control group, while the associations of indicators characterizing the circulatory system with the occupational stress factors are higher in the control group, which indicates the importance of the formation of stress resistance, achieved by a high requirements of the professional selection, regular training of professional skills, as well as the creation of a favorable professional climates.
Comparative pharmacoeconomic analysis of metastatic colorectal cancer treatment
Authors: Petukhova Yulia Yu. , Eliseeva Ekaterina V. , Apanasevich Vladimir I. , Petukhova Antonina G. , Ovodova Anna V.
Published: January 2022

Every year, the pharmacological market offers new medicines to increase the survival rate and improve the quality of life of patients with cancer. However, while significantly exceeding the cost of existing methods of pharmacotherapy, new technologies often lead to only a small increased efficiency. Budget resources of health care dictate the need for a rational choice of pharmacotherapeutic options for malignant neoplasms that meet the principles of ensuring maximum results and accessibility for the entire population. An important role in solving this problem is played by such a direction of pharmacoeconomic analysis as the cost-effectiveness method. Colorectal cancer is one of the three oncological diseases that cause the greatest socio-economic burden for the state, which is associated with the highest costs of the Russian Federation health care system. Concurrently, in the last decade, a much more favorable prognosis has been identified for patients with metastatic colorectal cancer due to the development of effective approaches to antitumor pharmacotherapy. Conducting a pharmacoeconomic review that takes into account both clinical and economic indicators when using classic chemotherapy regimens and new targeted drugs will determine the effectiveness of finances that are spent to combat this malignancy. Additionally, the need to further individualize the therapy of patients suffering from metastatic colorectal cancer and lower prices for modern antitumor drugs is undeniable.
Metabolic and anxiety-depressive disorders in patients with polymorbid cardiovascular disease
Authors: Partsernyak Alexander S. , Kryukov Evgeny V. , Tsygan Vasily N. , Kurasov Evgeny S. , Ovchinnikov Dmitrii V.
Published: January 2022

The peculiarities of the influence of the metabolic disorders and depressive spectrum disorders in the development of polymorbid pathology are investigated. 160 male patients were examined, divided into three groups. The first group included 56 young men, 3940.2 years old, body mass index 34.235 kg/m2, suffering from the polymorbid cardiovascular pathology, in which the presence of coronary heart disease, angina pectoris of the functional class III, arterial hypertension 23 degrees, obesity 12 degrees, depressive spectrum disorders was considered. The second group included 56 middle-aged men, 47.548.3 years old, body mass index 36.236.9 kg/m2 with a similar combination of diseases of the first group. The third (control group) included 48 young men, 39.640.9 years old, body mass index 24.124.9 kg/m2, suffering from the polymorbid cardiovascular pathology without the metabolic syndrome and obesity. The anthropometric status, glucose, insulin, total cholesterol, triglycerides, and low-density lipoproteins were assessed. Instrumental diagnostics of the coronary heart disease and hypertension was carried out, anxiety and depressive disorders were established based on the results of a questionnaire and a consultation with a psychiatrist. It was found that in a group of young and middle-aged patients suffering from the polymorbid cardiovascular pathology, in combination with a metabolic syndrome and depressive spectrum disorders, psychopathological disorders (borderline anxiety-depressive state) are associated with the metabolic disorders, high prevalence of pain-free form of myocardial ischemia and unfavorable variants of two-phase blood pressure rhythm during the day, according to the type of insufficient degree of reduction of nocturnal blood pressure non-dippers and a steady increase in the night blood pressure night-peakers, which determines a high risk of cardiovascular complications.
Features of clinical and laboratory diagnostics of hantavirus infection at a prehospital stage
Authors: Kan Elena A. , Salukhov Vladimir V. , Rudakov Yury V. , Kovalenko Alexander N. , Golubtsov Oleg Y.
Published: January 2022

The features of clinical and laboratory diagnostics of hantavirus infection at the prehospital stage in the regions of the Northwestern Federal District is considered. The analysis of the terms of patients treatment from the moment of the appearance of the first symptoms of the disease was carried out. It was found that more than half of the patients sought a medical help during the height of the disease. The structure of hospitalizations of the patients with a hemorrhagic fever with renal syndrome who were admitted to inpatient treatment was studied; most patients were hospitalized by the ambulance team. The data of our own research are presented, indicating the predominance of the nonspecific symptoms in the onset of the disease. The overwhelming majority of the patients in the initial period of the disease had fever, severe headache, myalgia. Hemorrhagic syndrome was detected in a minimal number of the patients. The dynamics of the clinical picture of a hemorrhagic fever with the renal syndrome in patients admitted to hospitals in St. Petersburg was analyzed. Diversity and a rapid change of the symptoms and syndromes in dynamics were noted. In the structure of diagnoses of the direction, diseases of the respiratory system prevailed. A smaller proportion of a preliminary diagnoses were diseases of the gastrointestinal tract, pathology of the kidneys and urinary tract, diseases of the central nervous system, and only one patient was diagnosed with the hemorrhagic fever with renal syndrome. The laboratory parameters of the early period of the disease in patients were assessed. The most frequent and characteristic changes in the blood and urine parameters were revealed. Signs of hemoconcentration and thrombocytopenia were noted in almost half of the patients in the initial period of the disease. In a small part of outpatients, impaired renal nitrogen excretory function was found; the intensity of azotemia in the initial period of the diseases was low. Urine changes in the initial period were characterized by the moderate proteinuria, leukocyturia, erythrocyturia, cylindruria. The need for a thorough comparison of a clinical, laboratory, epidemiological data for a timely and correct diagnosis is noted.
Comparative value of purine metabolites in preeclampsia and acute cerebral stroke
Authors: Oreshnikov Evgeny V. , Oreshnikova Svetlana F. , Vasilyeva Elvira N. , Karpova Tatiana V. , Khabarova Olga Yu. , Denisova Tamara G.
Published: January 2022

The values of the purine metabolites in preeclampsia and acute cerebral stroke were compared. A total of 33 patients with preeclampsia and 350 patients with an acute cerebral stroke were examined. The blood and liquor guanine, hypoxanthine, adenine, xanthine, and uric acid were determined by a direct spectrophotometry, in addition to conventional laboratory parameters. It has been established that there are clinicalpathobiochemical parallels between preeclampsia and the cerebral stroke, including by the features of purine metabolism. It is known that the most pronounced adverse metabolic indicator (marker, predictor) for both preeclampsia and the cerebral stroke is hyperuricemia. It was revealed that the favorable sign for stroke is the high values of oxypurines (hypoxanthine, xanthin, and uric acid) in the cerebrospinal fluid, and for preeclampsia their low levels. It has been shown that cerebrospinal fluid is not only the medium of administration of the drugs for spinal anesthesia, but also a source of valuable diagnostic and prognostic information, including in preeclampsia. Preeclampsia is metabolically like stroke with an unfavorable significance of hyperuricemia and diametrically antagonistic to stroke with a favorable value not increased, but a reduced concentration of hypoxanthine, xanthin, and uric acid in cerebrospinal fluid. The level of uric acid and other purines in patients suffering from a preeclampsia and in patients suffering from a cerebral stroke should be determined not only in the blood serum, but also, as far as possible, in cerebrospinal fluid.