bluuebunny/crossref_metadata_2025 huggingface dataset:
Editor’s Note
Authors: Clement Richard W.
Published: June 2017

The articles in this issue were all originally delivered as papers at the 47th annual preconference of the Rare Books and Manuscripts section of the Association of College and Research Libraries held in Austin, Texas, June 20–23, 2006. Christian Dupont served as program planning chair for the preconference, arguably the most successful to date, and served as guest editor for this issue of RBM. He selected the papers to be included, worked with authors to turn their papers into articles, and collaborated with me through the whole editing process. As always, it was a pleasure to work with Christian.
Libraries, Archives, and Museums in the Twenty-First Century: Intersecting Missions, Converging Futures?
Authors: Dupont Christian
Published: June 2017

Libraries, archives, and museums are places where we learn about ourselves, the world around us, and what came before us. They inspire us to make a better future by helping us remember and understand the past. As cultural heritage institutions, libraries, archives, and museums share common goals to acquire, preserve, and make accessible artifacts and evidences of the world’s social, intellectual, artistic, even spiritual achievements. Yet to what extent do common goals imply common means? What benefits might be realized by bringing professionals from these allied fields into closer communication?
Asking these and related questions was the purpose of “Libraries, . . .
Cooperative Collection Building: A Response to Gerald Beasley
Authors: Whiteman Bruce
Published: June 2017

I would like to begin by disputing emphatically Gerald Beasley’s contention that librarians never become rich and famous. Sir Anthony Panizzi (1797–1879), Principal Librarian of the British Museum, was both, and so was Jorge Luis Borges (1899–1986), Director of the National Library in Buenos Aires. Well, perhaps Panizzi was not exactly a celebrity, and perhaps the source of Borges’s fame and riches was not his role as the National Librarian of Argentina. But what about the Abbé Rive, librarian to the Duc de la Vallière? He was infamous, if not famous, for being one of the most irascible . . .
Curatorial Reflections on Print Rooms and Libraries
Authors: Robison Andrew
Published: June 2017

The general relationship between libraries and museums is simply too broad a subject for me to wrestle with, although I am very glad that Gerald Beasley in his article in this issue has done such an excellent job of it. I intend, therefore, to focus on something more immediately relevant to my position, namely the relationship between libraries and museum collections of prints, or print rooms. That relationship, as you might expect, is a very close one. Whatever else libraries may collect—from musical instruments to eyeglasses to stuffed animals to other artifacts—and whatever else print rooms may have . . .
Libraries, Archives, and Museums: Achieving Scale and Relevance in the Digital Age
Authors: Michalko James
Published: June 2017

Over the years, I have heard many apologia for libraries, archives, and museums: why they are important, why they matter, and why we should care. In most cases, particularly in North America, the defense at some point invokes the role that cultural institutions play in the structure of a successful democracy: their support for the free flow of information that makes for an informed citizenry, and the preservation of a record of knowledge that enables choice and progress. Despite the fact that they are integrally bound up with American culture, I endorse all of those arguments; yet I do not . . .
“An Invented Archive”: The Disability History Museum
Authors: Block Laurie
Published: June 2017

The September 2006 issue of the Chronicle of Higher Education included a special supplement on “Diversity in Academic Careers.” It focused primarily on race and ethnicity; sexual preference received minimal attention. No references were made, however, to disability, although disabled Americans can be said to comprise the largest single “minority group” in the United States. Consider the following: according to the 2000 U.S. Census, 49.7 million people, representing 19.3 percent of the 257.2 million people aged five and older in the civilian noninstitutionalized population (or almost one in five U.S. residents), lives with some type of long-lasting condition or disability.
Robert W. Woodruff Library of the Atlanta University Center, Custodian of the Morehouse College Martin Luther King, Jr. Collection: “Until Further Notice”
Authors: Parham Loretta
Published: June 2017

On June 23, 2006, the American Library Association was holding its Annual Conference in New Orleans, Louisiana, the first major conference to return to the city post Hurricane Katrina. My scheduled visit of four days was abruptly cut short as a result of two communications: a call from Walter Massey, President of More-house College in Atlanta, Georgia, and an e-mail from William Potter, Dean of the University of Georgia Libraries. By the time the day was over, I learned that a collection of manuscripts and books documenting many of the writings, speeches, and notes of Dr. Martin Luther King, Jr. . . .
Fan Dancing and Fan Belts: Selling Optimism at the 1933 Chicago World’s Fair
Authors: Ganz Cheryl R.
Published: June 2017

In 1833, Chicago was a tiny backwoods settlement on the western frontier. It ranked as the world’s fourth largest city a century later. To celebrate the city’s remarkable rise, civic leaders and businessmen decided to host the city’s second world’s fair. The theme of this 1933–34 international exposition was “A Century of Progress.” Amazingly, in the midst of the Great Depression, this celebration championed corporate capitalism—the very culprit that many Americans blamed for their economic woes. The fair celebrated the advances of science and its application to consumer goods. Unlike earlier world’s fairs, this international venue de-emphasized the ...
The Ring and the Books
Authors: Whiteman Bruce
Published: June 2017

Do you see this ring?
~Robert Browning, The Ring and the Book (1868)
Thou shalt not ever bid on anything
When it’s so lucrative to form a ring.
~Ian Jackson, An Antiquarian ABC (1998)
In the auction trade, a “ring” refers to a group of buyers who collude before a sale to keep prices down by agreeing not to compete against one another. When the sale is over, all of the items that have been “ringed” are then reauctioned (the “knockout”) among the members of the ring in a private setting, and each more or less gets what he or . . .
El pensamiento religioso de Fernando Savater
Authors: Grijalba Uche Miguel
Published: June 2017

En el presente trabajo se presenta el pensamiento en materia religiosa de Fernando Savater. Savater es un autor que se define crédulo más que creyente, ante las sorpresas del pasado o de lo que esté por venir. Rechaza tanto la imposición de una verdad absoluta trascendente, al igual que muestra rechazo a las posturas escéptica o relativista. Para él, el origen de las creencia es el deseo: miedo a morir y el deseo de inmortalidad. Su noción de laicismo supone la concepción de una separación Iglesia y Estado, pero también la ausencia de todo fundamento prepolítico que condicione nuestra ciudadanía. De ahí la necesidad de explicar qué es el laicismo desde una asignatura como Educación para la Ciudadanía.
Hacia una topología del habla. El lenguaje de la denegación según Derrida
Authors: Valls Boix Juan Evaristo
Published: June 2017

El presente trabajo aborda la concepción derridiana del lenguaje como topología del habla a través de su lectura de la teología negativa. Esta topología del habla relativiza las posiciones y los límites del discurso y desvela su incompletud e insaturación semántica radicales, mostrándolo permanentemente abierto a la alteridad. Para ello, se expondrá la concepción derridiana de Dios como una desmesura o un significado continuamente diferido. A continuación, se estudiará su relación con el lenguaje a través de la lógica de la denegación. Tal lógica suspende las estructuras del discurso predicativo e invita a valorar el lenguaje como una dinámica de oración y la promesa.
Platón sobre la anomalía cívica del filósofo
Authors: Lavilla de Lera Jonathan
Published: June 2017

La filosofía es un producto histórico que se afianza definitivamente con Platón y Aristóteles. En tanto que constituye una novedad en el interior de la ciudad-estado, no sólo es mirada con desconfianza desde sus albores, sino que también es objeto de severas críticas. Los que se dedican a la filosofía son tildados de anómalos, como lo muestran algunos textos clásicos. En el contexto de su pensamiento y de su propuesta práctica, Platón dio continuidad a la imagen alocada del filósofo. No obstante, el Académico lo hizo de un modo irónico, mostrando que su extravagancia no reside en una desviación real respecto al comportamiento que por naturaleza es más idóneo para el humano, sino todo lo contrario, a saber, fruto de la errada opinión del vulgo. Precisamente, uno de los quehaceres más apremiantes para Platón en sus diálogos, además de precisar cuál es la naturaleza de la filosofía, es el de elaborar una defensa de la filosofía, presentándola como el modus vivendi más sensato y apropiado por naturaleza. Abstract: Philosophy is an historical product, which is definitively consolidated with Plato and Aristotle. As it constitutes a novelty within the polis, it is not just regarded with suspicion from its very beginning, but it is also the target of severe criticism. Those who are dedicated to philosophy are stigmatized as odd people, as it is shown by many classical texts. Regarding to his thought and his practical proposal, the Academic gave continuity to philosopher’s crazy image. However, he did so in an ironic way. He suggested that philosopher’s strangeness is not due to a real deviation from the behaviour that by nature is most suitable for humans, but the opposite, i.e. caused by the wrong opinions of those who are not philosophers. In fact, apart from well defining which is philosophy’s nature, one of the most urgent tasks that Plato has to deal with in his dialogues is to make a defence of philosophy as the best way of life, depicting it as the most sensible and according to nature.
Playful Participation in Social Games
Authors: Markussen Thomas , Knutz Eva
Published: June 2017

In this paper we introduce social games as a new terrain for studies in participatory culture. Social games defy easy classification and cannot be appropriately understood from existing research perspectives. Initially, we therefore attempt to define social games by comparing the genre with related game genres, notably serious games and health games. To further increase knowledge of social games, we introduce a typology of playful participation in social games. The typology is constructed by using formal concepts from theories of participatory art. Its range of application is then demonstrated through an empirical analysis of eight social game prototypes that are designed as part of an on-going three-year research project called “Social Games against Crime”. The purpose of this project is to develop social games that can help children build resilience towards many of the personal and social problems they experience as a result of parental incarceration.
Valuating intangible benefits from afforested areas: A case study in India
Authors: Jain Avinash , Chandra Girish , Nautiyal Raman
Published: June 2017

Environmental compensation measures usually accompany energy projects. Willingness-To-Pay (WTP) for five intangible benefits derived from afforested areas of a compensatory afforestation programme of National Thermal Power Corporation Dadri are estimated. Conventional Contingent Valuation shows the average WTP € 2.1 per respondent per month with more than 43 % of total WTP for ‘soil conservation and remediation’ and ‘improvement in underground water level’. Logit model method depicts the same order of magnitude but differs significantly at 5 % level for all the benefits. More informed decisions upon energy projects and afforestation programs shall help in conserving forests and their ecosystem services.
Zwischen objektiven Mythen und subjektiven Gefühlen - Eine Reflektion über das Cinematische Erlebnis mit Simmels Soziologie des Erlebens
Authors: Cantó-Milà Natàlia , Seebach Swen
Published: June 2017

This article sheds light on the experience which we share in the one and a half hours which we spend in the cinema. It discusses the experiences that are framed between the opening and the closing of the curtain that covers the screen. Thereby it reflects on the reasons for the success and importance of the cinema in modern and especially late modern society, on its meaning for us as individuals and for the webbing of our social bonds. By discussing texts of Simmel, Turner, Sennett and Benjamin, and relating them with each other, we have tried to analyse critically the changes that might have happened to actors and audiences when the stage became a screen, and the actor part of an imaged story. As a result we have identified the cinematic experience as a new kind of ritual that fits with the needs and conditions of late modern society, a ritual wherein emotions play the central role.
Reflexões de professores participantes em um Curso de Pedagogia Universitária
Authors: Corrêa Adriana Kátia , Blásida Concepcion Eliazur Benitez Catirse Alma , Garcia Soares Edson , Silva Glaucia Maria , Conceição Bernardo de Mello e Souza Maria , Fagundes Carvalho Gonçalves Marlene , Prestes Padilha Rivas Noeli , Iamamoto Yassuko
Published: June 2017

Este artigo analisa a formação de professores universitários, no contexto da pesquisa Curso Pedagogia Universitária: os professores e sua prática pedagógica desenvolvida pelo Grupo de Apoio Pedagógico do Campus USP-Ribeirão Preto/Universidade de São Paulo – Brasil – (GAPRP). Trata de pesquisa descritivo-exploratória, de natureza qualitativa que se propõe a analisar as reflexões de professores, participantes do I e II Curso de Pedagogia Universitária realizado em Ribeirão Preto em 2008 e 2009, acerca de sua prática pedagógica. Os dados revelam que as reflexões desses professores contemplam a revisitação de suas práticas pedagógicas, os limites contextuais e administrativos e a gestão do projeto político pedagógico com possibilidades de mudanças. Evidenciam-se também alguns pontos de tensão que necessitam ser trabalhados: aprendizagem da docência como perspectiva individual versus docência como perspectiva coletiva; formação pedagógica como prática sócio-política versus prática instrumental e valorização da pesquisa em detrimento do ensino.
Competências docentes para o ensino por competências na educação profissional: a percepção de docentes do Senac-PR frente ao Modelo Pedagógico Senac (MPS)
Authors: Aroca Antonio Carlos , Herrero Martins Menegassi Cláudia
Published: June 2017

A partir da mudança do modelo tradicional para o modelo de ensino por competência na educação profissional do Senac, observou-se a necessidade de alinhar as atividades docentes às diretrizes estabelecidas por esse novo modelo, o que requer também novas competências desses profissionais. A presente pesquisa teve como objetivo identificar as competências percebidas pelos docentes do Senac PR para o ensino na educação profissional necessárias à adequação de suas atividades aos objetivos do Modelo Pedagógico Senac (MPS), baseado no ensino por competências. Para atingir esse objetivo, foram entrevistados todos os docentes do curso com o maior número de turmas concluídas e em andamento – o curso Técnico em Enfermagem – utilizando-se os seguintes documentos: Modelo Pedagógico Senac (MPS), o plano de curso de Técnico em Enfermagem e o roteiro da entrevista. Os resultados obtidos estabelecem uma relação de competências, identificadas nas entrevistas, nas informações que representavam ou tinham alguma relação com a descrição de competência, que foram agrupadas por similaridade e descritas, o que permitiu elaborar uma base de competências necessárias aos docentes da educação profissional, diante do modelo pedagógico adotado pela instituição desde 2015.
Cinema, teatro, criatividade: metodologias ativas na formação discente do PIBID Pedagogia-UFV
Authors: Diniz Marques Emiliana Maria , Souza Rita de Cássia , Maciel Zico Vanessa
Published: June 2017

O presente trabalho é resultado das reflexões suscitadas a partir de um curso intitulado “Cinema, Teatro e Criatividade: experiências possíveis para reinvenções na escola”, oferecido para 20 estudantes bolsistas do Programa Institucional de Bolsa de Iniciação à Docência - PIBID, vinculado ao curso de Pedagogia da Universidade Federal de Viçosa - UFV. O curso contemplou os objetivos de: refletir sobre o encontro do cinema e do teatro com a educação, problematizando a sua utilização nas escolas; ampliar o contato das estagiárias do PIBID com experiências relacionadas ao cinema e às artes cênicas; e desenvolver atividades práticas para o trabalho com cinema e jogos teatrais na sala de aula. Foram ao todo dez encontros que, em conjunto, abarcaram atividades prático-teóricas envolvendo jogos e improvisações teatrais, brinquedos ópticos, exibição de filmes de curta metragem, produção de vídeos, contação de histórias, visita ao Museu da Comunicação da UFV, reflexões sobre a atuação profissional na sala de aula e relatos e trocas de experiências. Em todos os encontros, buscou-se estimular o protagonismo das estagiárias em relação às ações desenvolvidas por elas nas escolas com a apropriação das atividades de cinema e teatro realizadas no curso. Os impactos deste foram avaliados a partir de relatórios mensais nos quais as pibidianas apresentavam o que observaram e realizaram na atuação nas escolas. Acreditamos que o curso cumpriu o seu objetivo de fomentar novas experiências educativas que fossem inspiradoras para a prática das pibidianas de Pedagogia em atuação nas escolas básicas do ensino fundamental, hoje e no futuro.
Characteristics Predicting the Outcome in Individuals with Diabetic Foot Ulcerations
Authors: Vella Lourdes , Formosa Cynthia
Published: June 2017

Background:

We sought to determine patient and ulcer characteristics that predict wound healing in patients living with diabetes.

Methods:

A prospective observational study was conducted on 99 patients presenting with diabetic foot ulceration. Patient and ulcer characteristics were recorded. Patients were followed up for a maximum of 1 year.

Results:

After 1 year of follow-up, ulcer characteristics were more predictive of ulcer healing than were patient characteristics. Seventy-seven percent of ulcers had healed and 23% had not healed. Independent predictors of nonhealing were ulcer stage (P = .003), presence of biofilm (P = .020), and ulcer depth (P = .028). Although this study demonstrated that the baseline hemoglobin A1c reading at the start of the study was not a significant predictor of foot ulcer outcome (P = .603, resolved versus amputated), on further statistical analyses, when hemoglobin A1c was compared with the time taken for complete ulcer healing (n = 77), it proved to be significant (P = .009).

Conclusions:

The factors influencing healing are ulcer stage, presence of biofilm, and ulcer depth. These findings have important implications for clinical practice, especially in an outpatient setting. Prediction of outcome may be helpful for health-care professionals in individualizing and optimizing clinical assessment and management of patients. Identification of determinants of outcome could result in improved health outcomes, improved quality of life, and fewer diabetes-related foot complications.
Dorsal Fracture-Dislocation of the Tarsal Navicular
Authors: Jimenez Isidro , Rodriguez-Alvarez Juan Pedro , Navarro-Navarro Ricardo
Published: June 2017

Fracture-dislocations of the tarsal navicular are rare and highly complex injuries to the midfoot. The only published data on this type of fracture are clinical case reports. These injuries are normally caused by high-energy trauma, and their pathophysiology and most appropriate treatment remain unclear. We report a clinical case of a dorsal fracture-dislocation of the tarsal navicular bone associated with a medial swivel dislocation of the Chopart joint caused by a bicycle fall in a 20-year-old healthy man. Open reduction and percutaneous pinning in a novel arrangement was performed, with an excellent outcome 18 months after the injury.
The construction of sparse models of Mars's crustal magnetic field
Authors: Moore Kimberly M. , Bloxham Jeremy
Published: June 2017

Previous work has shown that Mars's crustal magnetic field is highly nonuniform, with large regions of either very weak or very strong magnetic field. Commonly used techniques of magnetic field analysis (such as truncation or L2 regularization of a spherical harmonic expansion) have a smoothing effect and are not well suited to representing magnetic fields which may have regions of zero magnetization or sharp contrasts in magnetization. Indeed, there is no a priori reason to expect that the crustal field should be smooth. In this study, we use L1 and elastic net regularizations of Mars Global Surveyor magnetometer data to create sparse representations of the magnetic field of Mars, and examine what percentage of the surface field is actually required to have nonzero magnetization in order to fit the data. We find that solutions with up to 98% or higher sparsity yield an adequate fit to the data, although solutions with 85% sparsity are more realistic. These sparse solutions are substantially different from other smoothed solutions. The choice of inversion method used to analyze the data significantly impacts the resulting field morphology, which may affect the resulting physical interpretation.
Potential benefits of crawl position for prone radiation therapy in breast cancer
Authors: Boute Bert , De Neve Wilfried , Speleers Bruno , Van Greveling Annick , Monten Christel , Van Hoof Tom , Van de Velde Joris , Paelinck Leen , De Gersem Werner , Vercauteren Tom , Detand Jan , Veldeman Liv
Published: June 2017

Purpose

To investigate crawl position with the arm at the treated side alongside the body and at the opposite side above the head for prone treatment in patients requiring breast and regional lymph node irradiation.

Methods

Patient support devices for crawl position were built for CT simulation and treatment. An asymmetric fork design resulted from an iterative process of prototype construction and testing. The fork's large horn supports the hemi‐thorax, shoulder, and elevated arm at the nontreated side and the head. The short, narrow horn supports the arm at the treated side. Between both horns, the treated breast and its regional lymph nodes are exposed. Endpoints were pain, comfort, set‐up precision, beam access to the breast and lymph nodes, and plan dose metrics. Pain and comfort were tested by volunteers (n = 9); set‐up precision, beam access, and plan dose metrics were tested by means of a patient study (n = 10). The AIO™ (Orfit, Wijnegem, Belgium) prone breastboard (AIO™) was used as a reference regarding comfort and set‐up precision.

Results

Pain at the sternum, the ipsilateral shoulder, upper arm, and neck was lower in crawl position than with bilateral arm elevation on AIO™. Comfort and set‐up precision were better on the crawl prototype than on AIO™. In crawl position, beam directions in the coronal and near‐sagittal planes have access to the breast or regional lymph nodes without traversing device components. Plan comparison between supine and crawl positions showed better dose homogeneity for the breast and lymph node targets and dose reductions to all organs at risk for crawl position.

Conclusions

Radiation therapy for breast and regional lymph nodes in crawl position is feasible. Good comfort and set‐up precision were demonstrated. Planning results support the hypothesis that breast and regional lymph nodes can be treated in crawl position with less dose to organs at risk and equal or better dose distribution in the target volumes than in supine position. The crawl technique is a candidate methodology for further investigation for patients requiring breast and regional lymph node irradiation.
Distinct Bimodal Roles of Aromatic Molecules in Controlling Gold Nanorod Growth for Biosensing
Authors: Soh Jun Hui , Lin Yiyang , Thomas Michael R. , Todorova Nevena , Kallepitis Charalambos , Yarovsky Irene , Ying Jackie Y. , Stevens Molly M.
Published: June 2017

New aromatic molecule–seed particle interactions are examined and exploited to control and guide seed‐mediated gold nanorod (Au NR) growth. This new approach enables better understanding of how small molecules impact the synthesis of metallic nanostructures, catalyzing their use in various biomedical applications, such as plasmonic biosensing. Experimental studies and theoretical molecular simulations using a library of aromatic molecules, making use of the chemical versatility of the molecules with varied spatial arrangements of electron‐donating/withdrawing groups, charge, and Au‐binding propensity, are performed. Au NR growth is regulated by two principal mechanisms, producing either a red or blue shift in the longitudinal localized surface plasmon resonance (LLSPR) peaks. Aromatic molecules with high redox potentials produce an increase in NR aspect ratio and red shift of LLSPR peaks. In contrast, molecules that strongly bind gold surfaces result in blue shifts, demonstrating a strong correlation between their binding energy and blue shifts produced. Through enzymatic conversion of selected molecules, 4‐aminophenylphosphate to 4‐aminophenol, opposing growth mechanisms at opposite extremes of target concentration are obtained, and a chemical pathway for performing plasmonic enzyme‐linked immunosorbent assays is established. This unlocks new strategies for tailoring substrate design and enzymatic mechanisms for controlling plasmonic response to target molecules in biosensing applications.
Inverse Opal Scaffolds and Their Biomedical Applications
Authors: Zhang Yu Shrike , Zhu Chunlei , Xia Younan
Published: June 2017

Three‐dimensional porous scaffolds play a pivotal role in tissue engineering and regenerative medicine by functioning as biomimetic substrates to manipulate cellular behaviors. While many techniques have been developed to fabricate porous scaffolds, most of them rely on stochastic processes that typically result in scaffolds with pores uncontrolled in terms of size, structure, and interconnectivity, greatly limiting their use in tissue regeneration. Inverse opal scaffolds, in contrast, possess uniform pores inheriting from the template comprised of a closely packed lattice of monodispersed microspheres. The key parameters of such scaffolds, including architecture, pore structure, porosity, and interconnectivity, can all be made uniform across the same sample and among different samples. In conjunction with a tight control over pore sizes, inverse opal scaffolds have found widespread use in biomedical applications. In this review, we provide a detailed discussion on this new class of advanced materials. After a brief introduction to their history and fabrication, we highlight the unique advantages of inverse opal scaffolds over their non‐uniform counterparts. We then showcase their broad applications in tissue engineering and regenerative medicine, followed by a summary and perspective on future directions.
Indium(III) Chloride Promoted One‐Pot Multicomponent Synthesis of 1,2,4‐Triazole Carrying 1,2,4‐Triazin‐6‐ones from Nitrile Imines and N,N′‐Bis(trimethylsilyl)carbodiimine
Authors: Tsai Shuo‐En , Yen Wan‐Ping , Li Yi‐Ting , Hu Yu‐Tzu , Tseng Ching‐Chun , Wong Fung Fuh
Published: June 2017

An indium(III) chloride/silica gel promoted one‐pot multicomponent reaction for the synthesis of 5‐[2‐(1,2,4‐triazol‐3‐yl)hydrazinyl]‐1,2,4‐triazin‐6‐ones was developed by treating hydrazonoyl hydrochlorides with N,N′‐bis(trimethylsilyl)carbodiimine. The first step of the reaction mechanism involves the promotion of the 1,3‐dipolar cycloaddition by indium(III) chloride/silica gel. The subsequent cyclization and substitution reaction sequence employs 2 equiv of the nitrile imine and the silylamide intermediate, which may be the key species, to lead to the product.
Symmetry Breaking Induced Geometric Surfaces with Topological Curves in Quantum and Classical Dynamics of the SU(2) Coupled Oscillators
Authors: Chen Y. F. , Tung J. C. , Tuan P. H. , Huang K. F.
Published: June 2017

In the three‐dimensional (3D) transversely symmetric oscillator, there are plentiful degeneracies and gaps in the quantum energy spectrum as a function of the ratio of the transverse to longitudinal frequency. It is theoretically verified that while the SU(2) interaction destroys the original degeneracies, numerous new degeneracies and gaps emerge around the original degeneracies to form a similar fine energy spectrum. The classical trajectories at the emergent degeneracies are analyzed to be localized on the 3D parametric surfaces which are constituted by the topologically invariant curves in the transverse tomography. The quantum coherent states are exploited to develop the wave functions that correspond to the 3D geometric surfaces in classical dynamics. Furthermore, the wave structures of the stationary coherent states at small quantum numbers are explored and found to display peculiar patterns with symmetries related to classical trajectories.
Fixierung von NiFe‐Hydrotalkit‐Pulverkatalysatoren für die postelektrolytische strukturelle Charakterisierung von Elektrokatalysatoren für die Sauerstoffevolution
Authors: Andronescu Corina , Barwe Stefan , Ventosa Edgar , Masa Justus , Vasile Eugeniu , Konkena Bharathi , Möller Sandra , Schuhmann Wolfgang
Published: June 2017

Hochaktive Katalysatoren für die Sauerstoffevolutionsreaktion (OER) sind in den meisten Fällen Nanomaterialen. Diese erfahren substantielle Veränderungen, hervorgerufen durch die notwendigen anodischen Potentiale und hohen Stromdichten während der Sauerstoffevolution. Die Lebensdauer katalysatormodifizierter Elektroden ist unter OER‐Bedingungen aufgrund der immensen Gasentwicklung und fehlender Strategien zur stabilen Pulverfixierung auf Elektrodenoberflächen enttäuschend kurz. Aussagekräftige Studien über Katalysatoren während und vor allem nach der OER sind davon häufig beeinträchtigt. Wir schlagen hier Kompositmaterialen basierend auf Polybenzoxazinen und organophil modifizierten NiFe‐Hydrotalkitstrukturen (LDH) zur Bildung eines hochstabilen und leitfähigen Katalysatorfilms vor. Diese erlauben die Charakterisierung des Katalysators vor und nach elektrokatalytischen Untersuchungen. Die Charakterisierung des Kompositmaterials durch Röntgenbeugung (XRD) und elektronenmikroskopischen Methoden (REM, TEM) vor und nach 100 Stunden Elektrolyse bei 60 °C in 5 m KOH bei einer angelegten Stromdichte von 200 mA cm−2 zeigen bisher nicht beobachtete strukturelle Veränderungen.
Fabrication and photocatalytic behavior of a novel nanocomposite hydrogels containing Fe‐octacarboxylic acid phthalocyanine
Authors: Yuan Zhicheng , Chen Dajun
Published: June 2017

A novel poly(ethylene glycol)‐based nanocomposite hydrogels containing Fe‐octacarboxylic acid phthalocyanine (FeOCAP)/magnetic attapulgite was successfully synthesized by in situ polymerization. Fourier transform infrared spectroscopy result showed the FeOCAP/magnetic attapulgite was successfully introduced into the hydrogels matrix. Besides, the hydrogen bond interactions existed between FeOCAP/attapulgite and hydrogels, which acted as the crosslink points in the hydrogels network, and meanwhile, stabilized the nanoparticles in hydrogel without phase separation. Photocatalytic activity studies confirmed that the as‐prepared nanocomposite hydrogels had excellent photocatalytic activity for rhodamine B photodegradation, as compared to the pure hygrogels. The rhodamine B removal percentage of the hydrogels could reach nearly 100% and the kinetics of photocatalytic degradation reaction was described by the Langmuir–Hinshelwood kinetics models. The hydrogels could be reused more than five times without losing any photodegradation ability, which indicated that the hydrogels would be potentially useful in dyes wastewater treatments. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 45428.
Interaction of [VIVO(acac)2] with Human Serum Transferrin and Albumin
Authors: Correia Isabel , Chorna Ielyzaveta , Cavaco Isabel , Roy Somnath , Kuznetsov Maxim L. , Ribeiro Nádia , Justino Gonçalo , Marques Fernanda , Santos‐Silva Teresa , Santos Marino F.A. , Santos Hugo M. , Capelo José L. , Doutch James , Pessoa João Costa
Published: June 2017

[VO(acac)2] is a remarkable vanadium compound and has potential as a therapeutic drug. It is important to clarify how it is transported in blood, but the reports addressing its binding to serum proteins have been contradictory. We use several spectroscopic and mass spectrometric techniques (ESI and MALDI‐TOF), small‐angle X‐ray scattering and size exclusion chromatography (SEC) to characterize solutions containing [VO(acac)2] and either human serum apotransferrin (apoHTF) or albumin (HSA). DFT and modeling protein calculations are carried out to disclose the type of binding to apoHTF. The measured circular dichroism spectra, SEC and MALDI‐TOF data clearly prove that at least two VO–acac moieties may bind to apoHTF, most probably forming [VIVO(acac)(apoHTF)] complexes with residues of the HTF binding sites. No indication of binding of [VO(acac)2] to HSA is obtained. We conclude that VIVO–acac species may be transported in blood by transferrin. At very low complex concentrations speciation calculations suggest that [(VO)(apoHTF)] species form.
Rational engineering of p‐hydroxybenzoate hydroxylase to enable efficient gallic acid synthesis via a novel artificial biosynthetic pathway
Authors: Chen Zhenya , Shen Xiaolin , Wang Jian , Wang Jia , Yuan Qipeng , Yan Yajun
Published: June 2017

Gallic acid (GA) is a naturally occurring phytochemical that has strong antioxidant and antibacterial activities. It is also used as a potential platform chemical for the synthesis of diverse high‐value compounds. Hydrolytic degradation of tannins by acids, bases or microorganisms serves as a major way for GA production, which however, might cause environmental pollution and low yield and efficiency. Here, we report a novel approach for efficient microbial production of GA. First, structure‐based rational engineering of PobA, a p‐hydroxybenzoate hydroxylase from Pseudomonas aeruginosa, generated a new mutant, Y385F/T294A PobA, which displayed much higher activity toward 3,4‐dihydroxybenzoic acid (3,4‐DHBA) than the wild‐type and any other reported mutants. Remarkably, expression of this mutant in Escherichia coli enabled generation of 1149.59 mg/L GA from 1000 mg/L 4‐hydroxybenzoic acid (4‐HBA), representing a 93% molar conversion ratio. Based on that, we designed and reconstituted a novel artificial biosynthetic pathway of GA and achieved 440.53 mg/L GA production from simple carbon sources in E. coli. Further enhancement of precursor supply through reinforcing shikimate pathway was able to improve GA de novo production to 1266.39 mg/L in shake flasks. Overall, this study not only led to the development of a highly active PobA variant for hydroxylating 3,4‐DHBA into GA via structure‐based protein engineering approach, but also demonstrated a promising pathway for bio‐based manufacturing of GA and its derived compounds. Biotechnol. Bioeng. 2017;114: 2571–2580. © 2017 Wiley Periodicals, Inc.
Mechanistic modeling of the loss of protein sieving due to internal and external fouling of microfilters
Authors: Bolton Glen R. , Apostolidis Alex J.
Published: June 2017

Fed‐batch and perfusion cell culture processes used to produce therapeutic proteins can use microfilters for product harvest. In this study, new explicit mathematical models of sieving loss due to internal membrane fouling, external membrane fouling, or a combination of the two were generated. The models accounted for membrane and cake structures and hindered solute transport. Internal membrane fouling was assumed to occur due to the accumulation of foulant on either membrane pore walls (pore‐retention model) or membrane fibers (fiber‐retention model). External cake fouling was assumed to occur either by the growth of a single incompressible cake layer (cake‐growth) or by the accumulation of a number of independent cake layers (cake‐series). The pore‐retention model was combined with either the cake‐series or cake‐growth models to obtain models that describe internal and external fouling occurring either simultaneously or sequentially. The models were tested using well‐documented sieving decline data available in the literature. The sequential pore‐retention followed by cake‐growth model provided a good fit of sieving decline data during beer microfiltration. The cake‐series and cake‐growth models provided good fits of sieving decline data during the microfiltration of a perfusion cell culture. The new models provide insights into the mechanisms of fouling that result in the loss of product sieving. © 2017 American Institute of Chemical Engineers Biotechnol. Prog., 33:1323–1333, 2017
Transformations of Some Sesquiterpene Lactones by Filamentous Fungi and Cytotoxic Evaluations
Authors: Cano‐Flores Arturo , Delgado Guillermo
Published: June 2017

Biotransformation is an economically and ecologically viable technology which has been used to modify the structures of many classes of biologically active products. Some fungi may be useful for the biotransformation of sesquiterpene lactones (SLs), leading to unusual structural changes that modify their biological activities, and other transformations mimic their biosynthetic pathways, generating evidences for the proposed biogenesis. Eight filamentous fungi were screened for their ability to transform different SLs (1 – 9), and microbial reactions yielded compounds 10 – 17, which in turn have been isolated as natural products, thus mimicking their biosynthesis. Their structures were identified based on NMR and MS spectroscopic analyses. The cytotoxicities of SLs 1, 4, 6, 7 and 9, and their biotransformed produts (10, 14, 15 and 17) against human cancer cell lines U251 (glia), PC3 (prostate), K562 (leukemia), HCT‐15 (colon), MCF7 (breast), and SKLU‐1 (lung), were determined, confirming that the presence of Michael acceptor is an important feature for the bioactivity.
Photoactivatable Mussel‐Based Underwater Adhesive Proteins by an Expanded Genetic Code
Authors: Hauf Matthias , Richter Florian , Schneider Tobias , Faidt Thomas , Martins Berta M. , Baumann Tobias , Durkin Patrick , Dobbek Holger , Jacobs Karin , Möglich Andreas , Budisa Nediljko
Published: June 2017

Marine mussels exhibit potent underwater adhesion abilities under hostile conditions by employing 3,4‐dihydroxyphenylalanine (DOPA)‐rich mussel adhesive proteins (MAPs). However, their recombinant production is a major biotechnological challenge. Herein, a novel strategy based on genetic code expansion has been developed by engineering efficient aminoacyl‐transfer RNA synthetases (aaRSs) for the photocaged noncanonical amino acid ortho‐nitrobenzyl DOPA (ONB‐DOPA). The engineered ONB‐DOPARS enables in vivo production of MAP type 5 site‐specifically equipped with multiple instances of ONB‐DOPA to yield photocaged, spatiotemporally controlled underwater adhesives. Upon exposure to UV light, these proteins feature elevated wet adhesion properties. This concept offers new perspectives for the production of recombinant bioadhesives.
Asymmetric Synthesis of Pyrrolidine‐Containing Chemical Scaffolds via Tsuji–Trost Allylation of N‐tert‐Butanesulfinyl Imines
Authors: Dawood Rafid S. , Georgiou Irene , Wilkie Ross P. , Lewis William , Stockman Robert A.
Published: June 2017

A simple and efficient asymmetric synthesis of novel sp3‐rich pyrrolidine chemical scaffolds over five steps starting from simple ketones is described. Key steps involve the use of tert‐butanesulfinamide as a chiral auxiliary to perform an asymmetric Tsuji–Trost allylation, with subsequent cross‐metathesis with an acrylate ester and reduction of the sulfinimine/cyclisation of the resulting amine giving the pyrrolidine scaffolds in high yields and diastereoselectivites. By removing the chiral auxiliary and functionalising the ester group, the resulting scaffold core can be further derivatised.
Protein–Glycan Quinary Interactions in Crowding Environment Unveiled by NMR Spectroscopy
Authors: Diniz Ana , Dias Jorge S. , Jiménez‐Barbero Jesús , Marcelo Filipa , Cabrita Eurico J.
Published: June 2017

Protein–glycan interactions as modulators for quinary structures in crowding environments were explored. The interaction between human galectin 3 (Gal‐3) and distinct macromolecular crowders, such as bovine and human serum albumin (BSA and HSA), Ficoll 70 and PEG3350, was scrutinized. The molecular recognition event of the specific ligand, lactose, by Gal‐3 in crowding conditions was evaluated. Gal‐3 interactions were monitored by NMR analysing chemical shift perturbation (CSP) and line broadening of 1H15N‐HSQC signals. The intensity of the Gal‐3 1H15N‐HSQC signals decreased in the presence of all crowders, due to the increase in the solution viscosity and to the formation of large protein complexes. When glycosylated containing samples of BSA and HSA were used, signal broadening was more severe than that observed in the presence of the more viscous solutions of PEG3350 and Ficoll 70. However, for the samples containing glycoproteins, the signal intensity of 1H15N‐HSQC recovered upon addition of lactose. We show that serum proteins interact with Gal‐3, through their α2,3‐linked sialylgalactose moieties exposed at their surfaces, competing with lactose for the same binding site. The quinary interaction between Gal‐3 and serum glycoproteins, could help to co‐localize Gal‐3 at the cell surface, and may play a role in adhesion and signalling functions of this protein.
CITplus: Jahrgang 20
Authors: Böck Barbara
Published: June 2017

No abstract.
Impact of Medicaid disenrollment in Tennessee on breast cancer stage at diagnosis and treatment
Authors: Tarazi Wafa W. , Bradley Cathy J. , Bear Harry D. , Harless David W. , Sabik Lindsay M.
Published: June 2017

BACKGROUND

States routinely may consider rollbacks of Medicaid expansions to address statewide economic conditions. To the authors' knowledge, little is known regarding the effects of public insurance contractions on health outcomes. The current study examined the effects of the 2005 Medicaid disenrollment in Tennessee on breast cancer stage at the time of diagnosis and delays in treatment among nonelderly women.

METHODS

The authors used Tennessee Cancer Registry data from 2002 through 2008 and estimated a difference‐in‐difference model comparing women diagnosed with breast cancer who lived in low‐income zip codes (and therefore were more likely to be subject to disenrollment) with a similar group of women who lived in high‐income zip codes before and after the 2005 Medicaid disenrollment. The study outcomes were changes in stage of disease at the time of diagnosis and delays in treatment of >60 days and >90 days.

RESULTS

Overall, nonelderly women in Tennessee were diagnosed at later stages of disease and experienced more delays in treatment in the period after disenrollment. Disenrollment was found to be associated with a 3.3‐percentage point increase in late stage of disease at the time of diagnosis (P = .024), a 1.9‐percentage point decrease in having a delay of >60 days in surgery (P = .024), and a 1.4‐percentage point decrease in having a delay of >90 days in treatment (P = .054) for women living in low‐income zip codes compared with women residing in high‐income zip codes.

CONCLUSIONS

The results of the current study indicate that Medicaid disenrollment is associated with a later stage of disease at the time of breast cancer diagnosis, thereby providing evidence of the potential negative health impacts of Medicaid contractions. Cancer 2017;123:3312‐9. © 2017 American Cancer Society.
Well‐Defined Cyanometallate Coordination‐Polymer Nanoarchitectures Realized by Wet‐Chemical Manipulation
Authors: Zhao Yanyi , Zhang Wei , Hu Ming
Published: June 2017

Cyano‐bridged coordination polymers have attracted wide interest owing to their promise in various applications such as molecular magnets, information storage, bio‐sensing, electrochromism, nanomedicine, catalysis, water treatment, and energy storage and conversion. Inspired by the great success of nanoengineering in noble metals and semiconductors, nanoarchitectonics of these cyano‐bridged coordination polymers has been actively explored for hunting new properties or functions with significant progress in understanding their crystallization habit and chemical stability. Although comprehensive information about the nanoarchitectonics of cyano‐bridged coordination polymers remains poorly elucidated, a systematic overview of recent advances in this area is strongly needed in order to make further progress on the basis of current developments. In this review, we intend to summarize the wet‐chemical manipulation strategies based on controlled crystallization and etching for nanostructuration of cyano‐bridged coordination polymers. Some examples of the relationship between the nanoarchitecture and the properties of the cyano‐bridged coordination polymers will be given.
Directional solidification of Fe‐Fe3c white eutectic alloy
Authors: Trepczyńska‐Łent M.
Published: June 2017

Directionally solidified samples of an Fe‐Fe3C white eutectic alloy were produced in a vacuum Bridgman‐type furnace to study their eutectic growth with pulling rates of 300, 450, and 600 mm/h and a constant temperature gradient of G = 33.5 K/mm. The interphase spacing was measured on these samples, and the samples were X‐ray investigated. A quantitative evaluation of the microstructure EBSD was made. Research was performed with the application of optical an optical microscope, SEM, and computer software for an image analysis of the NIS‐Elements. The dependence between parameter v and the interphase spacing was presented. For the white eutectic, an equation, that resembles the well‐known in the Jackson‐Hunt theory for a regular eutectic, was obtained, but it differed by two terms in equation This may confirm that the studied eutectic belongs to the anomalous class and is a quasi ‐ regular eutectic.
High‐pressure Bridgman growth and characterization of Cd1‐XMnXTe:Fe crystals
Authors: Kovalenko Nazar O. , Terzin Igor S. , Sulima Sergei V. , Poluboiarov Oleksii O. , Kapustnik Alexei K. , Sofronov Dmitry S. , Mateichenko Pavel F. , Dubina Natalia G. , Abashin Sergei L. , Fedorov Alexander G.
Published: June 2017

Doped, structurally perfect crystals of solid solution Cd1‐XMnXTe were grown by high‐pressure Bridgman method covering the range of its existence as a zinc blende structure (0 < x < 0.77). Structural, optical and mechanical properties of the crystals have been investigated. The interest in such investigations is mainly attracted due to the absence of information about optical properties of Cd1‐XMnXTe with x > 0.45, which is a potentially longest wavelength active material for mid‐IR lasing. Consequently, the correlation between the chemical composition and physical properties of the solid solution has been established.