bluuebunny/crossref_metadata_2025 huggingface dataset:
Magnetron-Sputtered Lead Titanate Thin Films for Pyroelectric Applications: Part 2—Electrical Characteristics and Characterization Methods
Authors: Fathipour Morteza , Xu Yanan , Rana Mukti
Published: January 2024

Pyroelectric materials are naturally electrically polarized and exhibits a built-in spontaneous polarization in their unit cell structure even in the absence of any externally applied electric field. These materials are regarded as one of the ideal detector elements for infrared applications because they have a fast response time and uniform sensitivity at room temperature across all wavelengths. Crystals of the perovskite lead titanate (PbTiO3) family show pyroelectric characteristics and undergo structural phase transitions. They have a high Curie temperature (the temperature at which the material changes from the ferroelectric (polar) to the paraelectric (nonpolar) phase), high pyroelectric coefficient, high spontaneous polarization, low dielectric constant, and constitute important component materials not only useful for infrared detection, but also with vast applications in electronic, optic, and MEMS devices. However, the preparation of large perfect and pure single crystals PbTiO3 is challenging. Additionally, difficulties arise in the application of such bulk crystals in terms of connection to processing circuits, large size, and high voltages required for their operation. In this part of the review paper, we explain the electrical behavior and characterization techniques commonly utilized to unravel the pyroelectric properties of lead titanate and its derivatives. Further, it explains how the material preparation techniques affect the electrical characteristics of resulting thin films. It also provides an in-depth discussion of the measurement of pyroelectric coefficients using different techniques.
Current Trends in Metallic Materials for Body Panels and Structural Members Used in the Automotive Industry
Authors: Trzepieciński Tomasz , Najm Sherwan Mohammed
Published: January 2024

The development of lightweight and durable materials for car body panels and load-bearing elements in the automotive industry results from the constant desire to reduce fuel consumption without reducing vehicle performance. The investigations mainly concern the use of these alloys in the automotive industry, which is characterised by mass production series. Increasing the share of lightweight metals in the entire structure is part of the effort to reduce fuel consumption and carbon dioxide emissions into the atmosphere. Taking into account environmental sustainability aspects, metal sheets are easier to recycle than composite materials. At the same time, the last decade has seen an increase in work related to the plastic forming of sheets made of non-ferrous metal alloys. This article provides an up-to-date systematic overview of the basic applications of metallic materials in the automotive industry. The article focuses on the four largest groups of metallic materials: steels, aluminium alloys, titanium alloys, and magnesium alloys. The work draws attention to the limitations in the development of individual material groups and potential development trends of materials used for car body panels and other structural components.
Forming Characteristics of Tailor Rolled Blank of Aluminum Alloy during Three-Point Bending
Authors: Zhi Ying , Feng Yue , Wang Dong , Hu Xianlei , Sun Tao , Liu Xianghua
Published: January 2024

This paper presents an investigation on the forming characteristics of the tailor rolled blank of an aluminum alloy (Al-TRB) during three-point bending at room temperature through experiments and finite element simulations. The strain distribution, spring-back characteristics, and metal flow law of 6000 series Al-TRB during three-point bending are explored. The prepared Al-TRB has good bending properties, and no surface cracks appear in the bending region of the Al-TRB when bent to 180°. Surface roughening occurs on the outside of the bending region. Since the strain in the thick zone is greater than that in the thin zone, the surface roughening in the thick zone is more obvious than that in the thin zone. The spring-back angle in the thin zone is higher than that in the thick zone after three-point bending, and the overall spring-back angle of Al-TRB becomes larger with an increasing bending angle. When the transition zone of Al-TRB is centered and the length of the transition zone is certain, as the length of the equal-thickness zone increases, the spring-back angle of the thin zone is larger, while the spring-back angle of the thick zone is smaller. Under the premise of a certain total length of Al-TRB and the length of the transition zone, the larger the length proportion of the thin zone, the larger the overall spring-back angle of Al-TRB, and the larger the length proportion of the thick zone, the smaller the overall spring-back angle of Al-TRB. In addition, a slight metal flow phenomenon exists during three-point bending, which shows that the metal in the bending region will flow to the thick zone, and the metal at the edge will flow to the thin zone. At the same time, there are localized thickening and thinning phenomena in Al-TRB. This study is helpful because it provides theoretical guidance for designing molds for the actual production of Al-TRB parts for automotives.
Densification and Surface Carbon Transformation of Diamond Powders under High Pressure and High Temperature
Authors: Mao Rongqi , Cui Xiwei , Hao Jinglin , Zhao Sizhuang , Hou Shuai , Lan Fuli , Li Yanbiao , Deng Lifen , Li He
Published: January 2024

A new type of poly-diamond plate without a catalyst was produced via the high-pressure high-temperature (HPHT) compression of diamond powders. The densification of diamond powders and sp3 to sp2 carbon on the surface under HPHT compression was investigated through the characterization of the microstructure, Raman spectroscopy analysis and electrical resistance measurement. The densification and sp3-sp2 transformation on the surface are mainly affected by the pressure, temperature and particle size. The quantitative analysis of the diamond sp3 and sp2 carbon amount was performed through the peak fitting of Raman spectra. It was found that finer diamond particles under a higher temperature and a lower pressure tend to produce more sp2 carbon; otherwise, they produce less. In addition, it is interesting to note that the local residual stresses measured using Raman spectra increase with the diamond particle size. The suspected reason is that the increased particle size reduces the number of contact points, resulting in a higher localized pressure at each contact point. The hypothesis was supported by finite element calculation. This study provides detailed and quantitative data about the densification of diamond powders and sp3 to sp2 transformation on the surface under HPHT treatment, which is valuable for the sintering of polycrystalline diamonds (PCDs) and the HPHT treatment of diamonds.
Derivative-Variance Hybrid Global Sensitivity Measure with Optimal Sampling Method Selection
Authors: Liu Jiacheng , Liu Haiyun , Zhang Cong , Cao Jiyin , Xu Aibo , Hu Jiwei
Published: January 2024

This paper proposes a derivative-variance hybrid global sensitivity measure with optimal sampling method selection. The proposed sensitivity measure is as computationally efficient as the derivative-based global sensitivity measure, which also serves as the conservative estimation of the corresponding variance-based global sensitivity measure. Moreover, the optimal sampling method for the proposed sensitivity measure is studied. In search of the optimal sampling method, we investigated the performances of six widely used sampling methods, namely Monte Carlo sampling, Latin hypercube sampling, stratified sampling, Latinized stratified sampling, and quasi-Monte Carlo sampling using the Sobol and Halton sequences. In addition, the proposed sensitivity measure is validated through its application to a rural bridge.
Modeling Partners’ Behavior in Long-Lasting B2B Supply Chain Relationships
Authors: Ferro-Soto Carlos , Padín Carmen , Otero-Neira Carmen , Svensson Göran
Published: January 2024

Companies have strengthened their long-term inter-organizational partnerships throughout the supply chain to neutralize competitive pressures and risks in uncertain environments. On this basis, this research aims to propose and test a model of partners’ behavior aimed at the maintenance of long-term collaboration. By using confirmatory factor analysis, structural equation modeling, and rival model testing, the theoretical model proposed attempts to identify, from a seller’s perspective, the critical variables of partners’ behavior. It also seeks to understand the effect of satisfaction between trust and commitment (as antecedents associated with relationship quality) and sales formalization, sales opportunism, and sales-specific assets (as postcendents linked to relationship efficiency). Our findings verify the nomological framework and demonstrate that the partnership quality variables affect relationship efficiency, through sales satisfaction. However, the results of our research cannot confirm the relationship between satisfaction and specific assets. This research is relevant as it deals with inter-organizational partnerships from a seller-oriented approach, and it is based on a combination of Relationship Marketing Theory and Transaction Cost Theory to demonstrate that the inter-organizational partnership quality variables exert a direct effect on the partnership efficiency variables.
Towards Dynamic Fuzzy Rule Interpolation via Density-Based Rule Promotion from Interpolated Outcomes
Authors: Lin Jinle , Shang Changjing , Shen Qiang
Published: January 2024

Traditional fuzzy rule-based systems struggle with scenarios where knowledge gaps exist in the problem domain, due to limited data or experience. Fuzzy rule interpolation (FRI) effectively addresses the challenge of inference in fuzzy systems when faced with unmatched observations, due to the employment of an incomplete or sparse rule base. It generates temporary, interpolated rules for the unmatched observations, ensuring continued inference capability. However, the resultant valuable interpolated rules are conventionally discarded. This paper introduces a formal approach for dynamic fuzzy rule interpolation (D-FRI), based on the concept of density-based rule promotion and assisted by the use of the OPTICS clustering algorithm, through exploiting frequently appearing interpolated rules on the fly. This enhances the system’s knowledge coverage, efficiency, and robustness over time. An implementation of such a D-FRI system is presented, which combines transformation-based fuzzy rule interpolation (T-FRI) with OPTICS clustering. This offers an effective mechanism for evaluating and subsequently selecting potentially powerful interpolated rules for the system to dynamically enrich its knowledge base. The implemented system is verified by experimental investigations.
Application of Mass Service Theory to Economic Systems Optimization Problems—A Review
Authors: Galimulina Farida F. , Barsegyan Naira V.
Published: January 2024

An interdisciplinary approach to management allows for the integration of knowledge and tools of different fields of science into a unified methodology in order to improve the efficiency of resource management of different kinds of systems. In the conditions of global transformations, it is economic systems that have been significantly affected by external destabilizing factors. This determines the focus of attention on the need to develop tools for the modeling and optimization of economic systems, both in terms of organizational structure and in the context of resource management. The purpose of this review study is to identify the current gaps (shortcomings) in the scientific literature devoted to the issues of the modeling and optimization of economic systems using the tools of mass service theory. This article presents a critical analysis of approaches for the formulation of provisions on mass service systems in the context of resource management. On the one hand, modern works are characterized by the inclusion of an extensive number of random factors that determine the performance and efficiency of economic systems: the probability of delays and interruptions in mobile networks; the integration of order, inventory, and production management processes; the cost estimation of multi-server system operation; and randomness factors, customer activity, and resource constraints, among others. On the other hand, controversial points are identified. The analytical study carried out allows us to state that the prevailing majority of mass service models applied in relation to economic systems and resource supply optimization are devoted to Markov chain modeling. In terms of the chronology of the problems studied, there is a marked transition from modeling simple systems to complex mass service networks. In addition, we conclude that the complex architecture of modern economic systems opens up a wide research field for finding a methodology for assessing the dependence of the enterprise performance on the effect of optimization provided by using the provisions of mass service theory. This statement can be the basis for future research.
Manin Triples and Bialgebras of Left-Alia Algebras Associated with Invariant Theory
Authors: Kang Chuangchuang , Liu Guilai , Wang Zhuo , Yu Shizhuo
Published: January 2024

A left-Alia algebra is a vector space together with a bilinear map satisfying the symmetric Jacobi identity. Motivated by invariant theory, we first construct a class of left-Alia algebras induced by twisted derivations. Then, we introduce the notions of Manin triples and bialgebras of left-Alia algebras. Via specific matched pairs of left-Alia algebras, we figure out the equivalence between Manin triples and bialgebras of left-Alia algebras.
Asymptotic Tracking Control for Mismatched Uncertain Systems with Active Disturbance Rejection
Authors: Yang Guichao , Cui Longfei
Published: January 2024

By introducing a set of exact disturbance estimators, a continuously tracking controller for a class of mismatched uncertain systems with exogenous disturbances will be proposed. The most appealing superiority is that the proposed exact disturbance estimators can not only estimate the external disturbances but also achieve an asymptotic estimation performance. Furthermore, with the help of a set of first-order asymptotic filters and an auxiliary system, the developed control algorithm is able to compensate for these total disturbances feedforwardly. Consequently, the whole closed-loop stability with an asymptotic tracking performance is strictly analyzed, and meanwhile applications are conducted to indicate the effectiveness of the proposed controller.
The Age of Older Patients Requiring Prolonged Mechanical Ventilation Is Not the Sole Determinant of Their Long-Term Survival
Authors: Huang Chienhsiu
Published: January 2024

Background and Objectives: There are few data on the effects of prolonged mechanical ventilation on elderly patients. Our objective is to investigate the effects of prolonged mechanical ventilation on older patients’ successful weaning and long-term survival. Methods: We examined how aging affected the course and results of elderly patients on prolonged mechanical ventilation by contrasting five age groups. Age, sex, cause of acute respiratory failure, comorbidities, discharge status, weaning status, and long-term survival outcomes were among the information we gathered. Results: Patients on prolonged mechanical ventilation who had undergone tracheostomy and had been successfully weaned had a greater one-year survival rate. The 1-year survival rate was poorer for older patients with four or more comorbidities. Regarding the 5-year survival rate, the risk of death was 45% lower in the successfully weaned patients than in the unsuccessfully weaned patients. The risk of death was 46% lower in patients undergoing tracheostomy than in those not undergoing tracheostomy. Older prolonged mechanical ventilation (PMV) patients with four or more comorbidities had an increased risk of death. Conclusions: When it comes to elderly patients on prolonged mechanical ventilation, there are other factors in addition to age that influence long-term survival. Long-term survival is likewise linked to successful weaning and undergoing tracheostomy.
A Review on Endoscopic Management of Acute Cholecystitis: Endoscopic Ultrasound-Guided Gallbladder Drainage and Endoscopic Transpapillary Gallbladder Drainage
Authors: Manudhane Albert P. , Leupold Matthew D. , Shah Hamza W. , Shah Raj , Han Samuel Y. , Lee Peter J. , Burlen Jordan J. , Papachristou Georgios I. , Krishna Somashekar G.
Published: January 2024

A percutaneous cholecystostomy tube (PCT) is the conventionally favored nonoperative intervention for treating acute cholecystitis. However, PCT is beset by high adverse event rates, need for scheduled reintervention, and inadvertent dislodgement, as well as patient dissatisfaction with a percutaneous drain. Recent advances in endoscopic therapy involve the implementation of endoscopic transpapillary drainage (ETP-GBD) and endoscopic ultrasound-guided gallbladder drainage (EUS-GBD), which are increasingly preferred over PCT due to their favorable technical and clinical success combined with lower complication rates. In this article, we provide a comprehensive review of the literature on EUS-GBD and ETP-GBD, delineating instances when clinicians should opt for endoscopic management and highlighting potential risks associated with each approach.
The Relationship between Depression Symptoms and Physical Activity in Children with Idiopathic Ventricular Extrasystoles
Authors: Kunigeliene Rita , Kinciniene Odeta , Usonis Vytautas , Lesinskiene Sigita
Published: January 2024

Background and Objectives: Depression in childhood often co-occurs with anxiety disorders and a range of somatic symptoms. Recent studies have identified physical activity as a target for preventing the onset of depression. However, idiopathic ventricular extrasystoles (VEs) in children are sometimes associated with somatic symptoms and limitations in physical activity. The occurrence of arrhythmia can also be distressing for children and their parents. This study was conducted to determine the relationship between symptoms of depression, physical activity, and somatic symptoms in children with idiopathic VE. Materials and Methods: This study of children with structurally normal hearts and VE was approved by the local ethics committee (no. 2021/10-1383˗859(1). The authors designed a questionnaire to assess symptoms, physical activity, and general well-being. As part of that, symptoms of depression were evaluated with a modified pediatric PHQ-9 (MP-PHQ-9) questionnaire, with scores ≤4 for no, 5–9 for mild, 10–14 for moderate, and ≥15 for severe depression. Children aged ≥12 years and parents who assessed their children’s condition completed the questionnaires. All children also underwent 24-h electrocardiography and echocardiography to evaluate arrhythmia frequency and cardiac condition. Results: Questionnaires were completed by 60 children’s parents and 39 children (≥12 years old). The median children’s age was 13 years. Palpitations were experienced by 26 (43.3%), chest pain by 13 (21.7%), and exercise intolerance by 15 (25%) children. All patients had normal ventricular function and hemodynamically normal hearts. The median score of the MP-PHQ-9 completed by parents was 2, and by children was 4. The median VE frequency was 4.77 (0.1–32.77) % per 24 h. We found that 31 (51.7%) children engaged in extra-sports participation with a median time of 3.75 h per week. Eleven of the children were suspended from sports. There was no significant difference between VE frequency and MP-PHQ-9 scores. Higher MP-PHQ-9 scores were noted for symptomatic children who engaged in <5 h per week of physical activity. Conclusions: Higher depression scores were found for children with somatic symptoms than those without symptoms. Children who were physically active for less than 5 h per week also had higher depression risk scores than those who were more active. Our research has shown that parents underestimate the signs of depression in their children.
From Anxiety to Hardiness: The Role of Self-Efficacy in Spanish CCU Nurses in the COVID-19 Pandemic
Authors: Gil-Almagro Fernanda , García-Hedrera Fernando José , Carmona-Monge Francisco Javier , Peñacoba-Puente Cecilia
Published: January 2024

Background and Objectives: Evidence shows that throughout the COVID-19 pandemic, nurses suffered from emotional symptoms, yet in spite of this, few studies within “positive psychology” have analyzed the emergence/promotion of positive traits, such as hardiness. In this context, the present study aimed to test a model regarding the mediating role of self-efficacy between anxiety experienced at the beginning of the COVID-19 pandemic and hardiness assessed six months later among nurses in critical care units (CCU) in Spain. Materials and Methods: An observational, descriptive, prospective longitudinal study with two data collection periods: (1) from the 1 to the 21 June 2020 (final phase of the state of alarm declared in Spain on 14 March) in which socio-demographic and occupational variables, anxiety (Depression, Anxiety and Stress Scale, DASS-21), self-efficacy (General Self-Efficacy Scale, GSES) and basal resilience (Resilience Scale-14, RS-14) were assessed, and (2) a follow-up 6 months later (January–March 2021) in which hardiness (Occupational Hardiness Questionnaire, OHQ) was evaluated. To analyze the data, multivariate regressions were performed using the PROCESS macro (simple mediation, model 4). Results: A total of 131 Spanish nurses from CCUs, with a mean age of 40.54 years (88.5% women) participated in the study. Moderate and severe levels of anxiety were observed in 19.1% of the sample. Significant and positive correlations were observed between self-efficacy, hardiness and resilience (all p < 0.001). Significant negative correlations were observed between anxiety and self-efficacy (p < 0.001), hardiness (p = 0.027) and resilience (p = 0.005). The indirect effect of anxiety on hardiness through self-efficacy was significant (Effect (SE) = −0.275 (0.100); LLCI = −0.487, ULCI = −0.097), contributing to 28% of the variance, including resilience (p = 0.015), age (p = 0.784), gender (p = 0.294) and years of experience (p = 0.652) as covariates. A total mediation was observed (non-significant anxiety-hardiness direct effect; Effect (SE) = −0.053 (0.215), t = 0.248, p = 0.804, LLCI = −0.372, ULCI = 0.479). Conclusions: The results suggest that in Spanish CCU nurses, anxiety experienced at the beginning of the COVID-19 pandemic may contribute to the development of hardiness through positive resources such as self-efficacy.
Physical Activity and Cognitive Functioning
Authors: Latino Francesca , Tafuri Francesco
Published: January 2024

Neuroscience applied to motor activity is a growing area that aims to understand the effects of motor activity on the structures and functions of the Central Nervous System. Attention has been paid to this multidisciplinary field of investigation by the scientific community both because it is of great importance in the treatment of many chronic diseases and because of its potential applications in the Movement Sciences. Motor activity during a developmental age is, in fact, an indispensable tool for the physical and mental growth of children, both able-bodied and disabled. Through movement, individuals can improve their physical efficiency and promote their own better health, establish relationships with the environment and others, express themselves and their emotions, form their identity and develop cognitive processes. This literature review aims, therefore, to highlight how an adequate practice of motor activity offers extraordinary possibilities for everyone in relation to learning, from the perspective of an integral development of the person, and, consequently, can raise the awareness of those involved in the training and growth, especially the youngest, towards the educational value of motor and sports activities. According to this review, and in line with the modern neuroscientific approach toward the relationships between motor activities and cognitive functions, it is possible to claim that hypokinesia tends to inhibit learning. Therefore, it now seems more topical than ever to draw attention to the need to introduce working proposals that integrate brain-based motor activity programs into the school curriculum.
Spontaneous Coronary Artery Dissection in Clinical Practice: Pathophysiology and Therapeutic Approaches
Authors: D’Amato Andrea , Mariani Marco Valerio , Prosperi Silvia , Colombo Lorenzo , De Prisco Andrea , Lavalle Carlo , Mancone Massimo , Vizza Carmine Dario , Severino Paolo
Published: January 2024

Spontaneous coronary artery dissection (SCAD) is a cause of myocardial infarction without obstructive coronary artery disease (MINOCA). It is determined by a coronary artery wall layers separation, which occurs regardless of traumatic or iatrogenic injuries. Even if it is often a missed diagnosis, its incidence is growing along with the improvement of intracoronary imaging techniques that allow for better detection. The main angiographical classification distinguishes three different forms, with slightly different prognoses at long-term follow up. SCAD is a recurrent condition, severely hampering the life quality of affected patients. The predominantly young age of patients with SCAD and the high prevalence of females among them have made the topic increasingly important, especially regarding therapeutic strategies. According to the data, the most recommended treatment is conservative, based on the use of antiplatelet agents and supportive anti-ischemic therapy. However, there are conflicting opinions concerning the need for dual antiplatelet therapy and its duration. In the case of invasive treatment, the choice between percutaneous coronary intervention and coronary artery bypass graft depends on the patient’s clinical stability and the interested vessel. The purpose of the current review is to revise the pathophysiological mechanisms underlying SCAD and the current knowledge of its treatment.
Acoustic Actuators for the Manipulation of Micro/Nanorobots: State-of-the-Art and Future Outlooks
Authors: Cao Hiep Xuan , Nguyen Van Du , Park Jong-Oh , Choi Eunpyo , Kang Byungjeon
Published: January 2024

Compared to other actuating methods, acoustic actuators offer the distinctive capability of the contactless manipulation of small objects, such as microscale and nanoscale robots. Furthermore, they have the ability to penetrate the skin, allowing for the trapping and manipulation of micro/nanorobots that carry therapeutic agents in diverse media. In this review, we summarize the current progress in using acoustic actuators for the manipulation of micro/nanorobots used in various biomedical applications. First, we introduce the actuating method of using acoustic waves to manipulate objects, including the principle of operation and different types of acoustic actuators that are usually employed. Then, applications involving manipulating different types of devices are reviewed, including bubble-based microrobots, bubble-free robots, biohybrid microrobots, and nanorobots. Finally, we discuss the challenges and future perspectives for the development of the field.
Bacterial Contamination of Platelet Products
Authors: Jacobs Michael R. , Zhou Bowen , Tayal Aditi , Maitta Robert W.
Published: January 2024

Transfusion of bacterially contaminated platelets, although rare, is still a major cause of mortality and morbidity despite the introduction of many methods to limit this over the past 20 years. The methods used include improved donor skin disinfection, diversion of the first part of donations, use of apheresis platelet units rather than whole-blood derived pools, primary and secondary testing by culture or rapid test, and use of pathogen reduction. Primary culture has been in use the US since 2004, using culture 24 h after collection of volumes of 4–8 mL from apheresis collections and whole-blood derived pools inoculated into aerobic culture bottles, with limited use of secondary testing by culture or rapid test to extend shelf-life from 5 to 7 days. Primary culture was introduced in the UK in 2011 using a “large-volume, delayed sampling” (LVDS) protocol requiring culture 36–48 h after collection of volumes of 16 mL from split apheresis units and whole-blood derived pools, inoculated into aerobic and anaerobic culture bottles (8 mL each), with a shelf-life of 7 days. Pathogen reduction using amotosalen has been in use in Europe since 2002, and was approved for use in the US in 2014. In the US, recent FDA guidance, effective October 2021, recommended several strategies to limit bacterial contamination of platelet products, including pathogen reduction, variants of the UK LVDS method and several two-step strategies, with shelf-life ranging from 3 to 7 days. The issues associated with bacterial contamination and these strategies are discussed in this review.
An Assessment of Human Opportunistic Pathogenic Bacteria on Daily Necessities in Nanjing City during Plum Rain Season
Authors: Yu Xiaowei , Yin Yifan , Wu Zuoyou , Cao Hui
Published: January 2024

The plum rain season is a special climatic phenomenon in east Asia, which is characterized by persistent rainfall, a high temperature, and humidity, providing suitable environmental conditions for certain pathogenic bacteria, thus increasing the incidence of respiratory, gastrointestinal, and urinary diseases. However, studies on human opportunistic pathogenic bacteria communities during the plum rain season are still limited. In this study, the characteristics of human opportunistic pathogenic bacterial communities on daily necessities during the non-plum and plum rain seasons were investigated using high-throughput sequencing technology. The results revealed that the relative abundance of human opportunistic pathogenic bacteria was higher in the plum rain season (cotton cloth: 2.469%, electric bicycles: 0.724%, rice: 3.737%, and washbasins: 5.005%) than in the non-plum rain season (cotton cloth: 1.425%, electric bicycles: 0.601%, rice: 2.426%, and washbasins: 4.801%). Both temperature and relative humidity affected human opportunistic pathogenic bacterial communities. Stochastic processes dominated the assembly process of human opportunistic pathogenic bacterial communities, and undominated processes prevailed. The stability of the co-occurrence network was higher in the non-plum rain season than that in the plum rain season. In addition, the proportion of deterministic processes showed the same trend as the complexity of the co-occurrence network.
A Revision of Herpes Simplex Virus Type 1 Transcription: First, Repress; Then, Express
Authors: Dunn Laura E. M. , Birkenheuer Claire H. , Baines Joel D.
Published: January 2024

The herpes virus genome bears more than 80 strong transcriptional promoters. Upon entry into the host cell nucleus, these genes are transcribed in an orderly manner, producing five immediate–early (IE) gene products, including ICP0, ICP4, and ICP22, while non-IE genes are mostly silent. The IE gene products are necessary for the transcription of temporal classes following sequentially as early, leaky late, and true late. A recent analysis using precision nuclear run-on followed by deep sequencing (PRO-seq) has revealed an important step preceding all HSV-1 transcription. Specifically, the immediate–early proteins ICP4 and ICP0 enter the cell with the incoming genome to help preclude the nascent antisense, intergenic, and sense transcription of all viral genes. VP16, which is also delivered into the nucleus upon entry, almost immediately reverses this repression on IE genes. The resulting de novo expression of ICP4 and ICP22 further repress antisense, intergenic, and early and late viral gene transcription through different mechanisms before the sequential de-repression of these gene classes later in infection. This early repression, termed transient immediate–early protein-mediated repression (TIEMR), precludes unproductive, antisense, intergenic, and late gene transcription early in infection to ensure the efficient and orderly progression of the viral cascade.
Development of Process Flow Sheet for Recovering Strategic Mineral Monazite from a Lean-Grade Bramhagiri Coastal Placer Deposit, Odisha, India
Authors: Singh Deependra , Mishra Bighnaraj , Sharma Ankit , Basu Suddhasatwa , Rao Raghupatruni Bhima
Published: January 2024

The present investigation deals with the development of a process flow sheet for recovering strategic mineral monazite concentrate from a lean-grade offshore placer deposit of the Bramhagiri coast along the southeast coast of Odisha, India.In the present study, both dry and wet processes are investigated to improve the recovery and purity of monazite. The results of the pre-concentration studies reveal that by using multi-stage spiral concentrators, the Total Heavy Minerals [THM] have been upgraded to 97.8% with a monazite content of 0.33% from a feed sample containing 4.72% total heavy minerals and 0.01% monazite content. The beneficiation studies revealed that the feed was initially subjected to a high-tension separator, and the non-conducting fraction of the high-tension roll was further subjected to magnetic separation. The magnetic product was again subjected to a flotation process followed by cleaning of the flotation product using a magnetic separator. This magnetic product contains 98.89% monazite with 84% recovery and 0.28% yield from a spiral product containing 0.33% monazite and qualifies for extracting rare earths. It is worth recovering monazite mineral from even lean-grade deposits, as it is a source of uranium, thorium, and rare earth elements and is very high in demand for humankind due to technological advancements. In view of this, monazite recovery is not to be considered for the economic profitability of the process but for strategic requirements.
Influence of Clay Particle Interactions on Leaching Percolation in Ion-Adsorption-Type Rare Earth Ores
Authors: Wang Li , Li Liang , Li Kaizhong , Huang Li
Published: January 2024

Ion-adsorption-type rare earth ores (IRE-ores) are a vital source of rare earth elements globally. The percolation properties of the ore body significantly determine the ease of rare earth extraction using in situ leaching processes. This paper investigates the interactions among clay particles in ion-adsorption-type rare earth ores within aqueous solutions, utilizing methods such as mineral particle aggregation and settling and acid–base adsorption on mineral surfaces. Based on these analyses, this paper elucidates the influence of solution properties on the percolation process of ion-type rare earth ores during leaching. The results indicate that the electrostatic attraction between minerals in aqueous solutions is pronounced, enhancing the interaction and resulting in a notable instability of the aggregates. The aggregation of minerals impacts the viscous effect of water bound to the mineral surface on the solution, thereby affecting the percolation rate. Extremely low concentrations of SO42− and CH3COO− can act as surface modifiers, reducing the electrostatic attraction between particles and consequently increasing the leaching percolation rate.
Characteristics of Intermolecular Interactions between Encapsulated Molecules and the Lantern-Like Carcerand Superphanes
Authors: Jabłoński Mirosław
Published: January 2024

The main topic of the article is to provide the characteristics of individual intermolecular interactions present between three lantern-like superphanes and the H2O, NH3, HF, HCN, and MeOH molecules trapped inside them. Despite the large cavity, the freedom of the trapped molecules is significantly limited by the presence of numerous interaction sites on the side chains of the superphane molecule. It is shown that the molecule trapped inside the superphane is stabilized mainly by only one or, less often, two strong hydrogen bonds involving the imino nitrogen atom, but QTAIM calculations also suggest the presence of many other intermolecular interactions, mainly hydrogen bonds involving imino or central hydrogen atoms from the side chains of the superphane molecule. Moreover, it is also shown that the structural simplification of the side chains does not significantly affect both the size of the superphane molecule and the obtained encapsulation energies, which is important in modeling this type of carceplexes. Noticeably, the parent superphane considered here was previously synthesized by the group of Qing He, so the results obtained will help in understanding this type and similar systems.
Anti-Inflammatory Properties of Oxygenated Isocoumarins and Xanthone from Thai Mangrove-Associated Endophytic Fungus Setosphaeria rostrata
Authors: Koopklang Kedkarn , Choodej Siwattra , Hantanong Sujitra , Intayot Ratchadaree , Jungsuttiwong Siriporn , Insumran Yuwadee , Ngamrojanavanich Nattaya , Pudhom Khanitha
Published: January 2024

Chronic inflammation plays a crucial role in the development and progression of numerous chronic diseases. To search for anti-inflammatory metabolites from endophytic fungi isolated from plants growing in Thai mangrove areas, a chemical investigation of those fungi was performed. Five new oxygenated isocoumarins, setosphamarins A–E (1–5) were isolated from the EtOAc extract of an endophytic fungus Setosphaeria rostrata, along with four known isocoumarins and one xanthone. Their structures were determined by extensive spectroscopic analysis. The absolute configurations of the undescribed compounds were established by comparative analysis between experimental and calculated circular dichroism (ECD) spectroscopy. All the compounds were evaluated for their anti-inflammatory activity by monitoring nitric oxide inhibition in lipopolysaccharide-induced macrophage J774A.1 cells. Only a xanthone, ravenelin (9), showed potent activity, with an IC50 value of 6.27 μM, and detailed mechanistic study showed that it suppressed iNOS and COX-2 expression.
Exploration of Raw Pigmented-Fleshed Sweet Potatoes Volatile Organic Compounds and the Precursors
Authors: Yao Yanqiang , Zhang Rong , Jia Ruixue , Yao Zhufang , Qiao Yake , Wang Zhangying
Published: January 2024

Sweet potato provides rich nutrients and bioactive substances for the human diet. In this study, the volatile organic compounds of five pigmented-fleshed sweet potato cultivars were determined, the characteristic aroma compounds were screened, and a correlation analysis was carried out with the aroma precursors. In total, 66 volatile organic compounds were identified. Terpenoids and aldehydes were the main volatile compounds, accounting for 59% and 17%, respectively. Fifteen compounds, including seven aldehydes, six terpenes, one furan, and phenol, were identified as key aromatic compounds for sweet potato using relative odor activity values (ROAVs) and contributed to flower, sweet, and fat flavors. The OR sample exhibited a significant presence of trans-β-Ionone, while the Y sample showed high levels of benzaldehyde. Starch, soluble sugars, 20 amino acids, and 25 fatty acids were detected as volatile compounds precursors. Among them, total starch (57.2%), phenylalanine (126.82 ± 0.02 g/g), and fatty acids (6.45 μg/mg) were all most abundant in Y, and LY contained the most soluble sugar (14.65%). The results of the correlation analysis revealed the significant correlations were identified between seven carotenoids and trans-β-Ionone, soluble sugar and nerol, two fatty acids and hexanal, phenylalanine and 10 fatty acids with benzaldehyde, respectively. In general, terpenoids and aldehydes were identified as the main key aromatic compounds in sweet potatoes, and carotenoids had more influence on the aroma of OR than other cultivars. Soluble sugars, amino acids, and fatty acids probably serve as important precursors for some key aroma compounds in sweet potatoes. These findings provide valuable insights for the formation of sweet potato aroma.
Nonthermal Plasma Synthesis of Metallic Ti Nanocrystals
Authors: Tu Qiaomiao , Poerschke David L. , Kortshagen Uwe R.
Published: January 2024

Nanoscale metallic titanium (Ti) offers unique energetic and biocompatible characteristics for the aerospace and biomedical industries. A rapid and sustainable method to form purified Ti nanocrystals is still in demand due to their high oxygen affinity. Herein, we report the production of highly purified Ti nanoparticles with a nonequilibrium face center cubic (FCC) structure from titanium tetrachloride (TiCl4) via a capacitively coupled plasma (CCP) route. Furthermore, we demonstrate a secondary H2 treatment plasma as an effective strategy to improve the air stability of a thin layer of nanoparticles by further removal of chlorine from the particle surface. Hexagonal and cubic-shaped Ti nanocrystals of high purity were maintained in the air after the secondary H2 plasma treatment. The FCC phase potentially originates from small-sized grains in the initial stage of nucleation inside the plasma environment, which is revealed by a size evolution study with variations of plasma power input.
Recent Studies on Metal-Embedded Silica Nanoparticles for Biological Applications
Authors: Cho Hye-Seong , Noh Mi Suk , Kim Yoon-Hee , Namgung Jayoung , Yoo Kwanghee , Shin Min-Sup , Yang Cho-Hee , Kim Young Jun , Yu Seung-Ju , Chang Hyejin , Rho Won Yeop , Jun Bong-Hyun
Published: January 2024

Recently, silica nanoparticles (NPs) have attracted considerable attention as biocompatible and stable templates for embedding noble metals. Noble-metal-embedded silica NPs utilize the exceptional optical properties of novel metals while overcoming the limitations of individual novel metal NPs. In addition, the structure of metal-embedded silica NPs decorated with small metal NPs around the silica core results in strong signal enhancement in localized surface plasmon resonance and surface-enhanced Raman scattering. This review summarizes recent studies on metal-embedded silica NPs, focusing on their unique designs and applications. The characteristics of the metal-embedded silica NPs depend on the type and structure of the embedded metals. Based on this progress, metal-embedded silica NPs are currently utilized in various spectroscopic applications, serving as nanozymes, detection and imaging probes, drug carriers, photothermal inducers, and bioactivation molecule screening identifiers. Owing to their versatile roles, metal-embedded silica NPs are expected to be applied in various fields, such as biology and medicine, in the future.
Semitransparent Organic Photovoltaic Devices: Interface/Bulk Properties and Stability Issues
Authors: Paci Barbara , Righi Riva Flavia , Generosi Amanda , Guaragno Marco , Mangiacapre Emanuela , Brutti Sergio , Wagner Michael , Distler Andreas , Egelhaaf Hans-Joachim
Published: January 2024

In the present work, an insight on the morpho/structural properties of semitransparent organic devices for buildings’ integrated photovoltaics is presented, and issues related to interface and bulk stability are addressed. The organic photovoltaic (OPV) cells under investigation are characterized by a blend of PM6:Y6 as a photo-active layer, a ZnO ETL (electron transporting layer), a HTL (hole transporting layer) of HTL-X and a transparent electrode composed by Ag nanowires (AgNWs). The devices’ active nanomaterials, processed as thin films, and their mutual nanoscale interfaces are investigated by a combination of in situ Energy Dispersive X-ray Reflectometry (EDXR) and ex situ Atomic Force Microscopy (AFM), X-ray Diffraction (XRD) and micro-Raman spectroscopy. In order to discriminate among diverse concomitant aging pathways potentially occurring upon working conditions, the effects of different stress factors were investigated: light and temperature. Evidence is gained of an essential structural stability, although an increased roughness at the ZnO/PM6:Y6 interface is deduced by EDXR measurements. On the contrary, an overall stability of the system subjected to thermal stress in the dark was observed, which is a clear indication of the photo-induced origin of the observed degradation phenomenon. Micro-Raman spectroscopy brings light on the origin of such effect, evidencing a photo-oxidation process of the active material in the device, using hygroscopic organic HTL, during continuous illumination in ambient moisture conditions. The process may be also triggered by a photocatalytic role of the ZnO layer. Therefore, an alternative configuration is proposed, where the hygroscopic HTL-X is replaced by the inorganic compound MoOx. The results show that such alternative configuration is stable under light stress (solar simulator), suggesting that the use of Molybdenum Oxide, limiting the photo-oxidation of the bulk PM6:Y6 active material, can prevent the cell from degradation.
Malnutrition as a Risk Factor in the Development of Oral Cancer: A Systematic Literature Review and Meta-Analyses
Authors: Patini Romeo , Favetti Giaquinto Eleonora , Gioco Gioele , Castagnola Raffaella , Perrotti Vittoria , Rupe Cosimo , Di Gennaro Leonardo , Nocca Giuseppina , Lajolo Carlo
Published: January 2024

This systematic review and meta-analyses aimed to assess whether malnutrition may increase the incidence of oral cancer. Following the PRISMA statement, the research was conducted on PubMed, Scopus, and MEDLINE via OVID without any time restrictions. The risk of bias was assessed, and the quality of evidence for each performed meta-analysis was evaluated using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework. Sixty-one articles met the inclusion criteria and seven studies underwent quantitative evaluation. For our meta-analysis on hypovitaminosis B, three studies with a total of 90,011 patients were included. An odds ratio of 2.22 was found. Our meta-analysis on the correlation between vitamin C and oral cancer included one study with a total of 866 patients and the derived odds ratio was 1.06. Our meta-analysis on the relationship between vitamin D deficiency and the incidence of oral cancer included three studies with a total of 12,087 patients and the odds ratio was −2.58. The GRADE system showed a moderate strength of evidence due to the presence of studies with a high risk of bias and high indirectness of the data given. The present findings suggest that an inadequate intake of vitamins, particularly vitamin D, poses a risk for the onset of oral cancer.
Daily Consumption of Golden Berry (Physalis peruviana) Has Been Shown to Halt the Progression of Insulin Resistance and Obesity in Obese Rats with Metabolic Syndrome
Authors: Ángel-Martín Alberto , Vaillant Fabrice , Moreno-Castellanos Natalia
Published: January 2024

In a study addressing the high risk of chronic diseases in people with diabetes and obesity linked to metabolic syndrome, the impact of a Golden Berry diet was investigated using a diabetic animal model. Obese rats with diabetic characteristics were fed a diet containing five percent Golden Berry for 16 days. This study focused on various parameters including organ weights, expression of metabolic genes, and urinary biomarkers. Post-Golden Berry intake, there was a notable decrease in the body, liver, pancreas, visceral, and subcutaneous adipose tissue weights in these obese, hyperglycemic rats. In contrast, an increase in brown adipose tissue (BAT) cell mass was observed. This diet also resulted in reduced blood glucose levels and normalized plasma biochemical profiles, including cholesterol, triglycerides, LDL, and HDL levels. Additionally, it modulated specific urinary biomarkers, particularly pipe-colic acid, a primary marker for type 2 diabetes. Bioinformatics analysis linked these dietary effects to improved insulin signaling and adipogenesis. Regular consumption of Golden Berry effectively prevented insulin resistance and obesity in rats, underscoring its significant health benefits and the protective role of an antioxidant-rich diet against metabolic syndrome. These findings offer promising insights for future therapeutic strategies to manage and prevent obesity and related chronic diseases.